19544527	0	1-8D	10,14	IFITM2	21,27	1-8D	IFITM2	10581	10581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human 1-8D gene -LRB- IFITM2 -RRB- is a novel p53 independent pro-apoptotic gene .
18172866	0	1-cys_peroxiredoxin	41,60	B_cell-specific_activator_protein	73,106	1-cys peroxiredoxin	B cell-specific activator protein	11758(Tax:10090)	18507(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the murine 1-cys_peroxiredoxin gene by the B_cell-specific_activator_protein , Pax5 .
20404857	0	1-deoxy-D-xylulose-5-phosphate_reductoisomerase	18,65	DXR	67,70	1-deoxy-D-xylulose-5-phosphate reductoisomerase	DXR	836400(Tax:3702)	836400(Tax:3702)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Disruption of the 1-deoxy-D-xylulose-5-phosphate_reductoisomerase -LRB- DXR -RRB- gene results in albino , dwarf and defects in trichome initiation and stomata closure in Arabidopsis .
16263772	0	11Beta-hydroxysteroid_dehydrogenase_type_2	0,42	surfactant_protein_A	65,85	11Beta-hydroxysteroid dehydrogenase type 2	surfactant protein A	3291	653509	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	11Beta-hydroxysteroid_dehydrogenase_type_2 and the regulation of surfactant_protein_A by dexamethasone metabolites .
9331977	0	11_beta-hydroxylase_cytochrome_P450	65,100	CYP11B1	102,109	11 beta-hydroxylase cytochrome P450	CYP11B1	500892(Tax:10116)	500892(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of aldosterone_synthase_cytochrome_P450 _ -LRB- CYP11B2 -RRB- and 11_beta-hydroxylase_cytochrome_P450 -LRB- CYP11B1 -RRB- expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists .
22971074	0	11beta-HSD2	65,76	Corticotropin-releasing_hormone	0,31	11beta-HSD2	Corticotropin-releasing hormone	3291	1392	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone stimulates expression of leptin , 11beta-HSD2 and syncytin-1 in primary human trophoblasts .
22971074	0	11beta-HSD2	65,76	leptin	57,63	11beta-HSD2	leptin	3291	3952	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Corticotropin-releasing_hormone stimulates expression of leptin , 11beta-HSD2 and syncytin-1 in primary human trophoblasts .
19088256	0	11beta-hydroxysteroid_dehydrogenase_type_1	40,82	Tumor_necrosis_factor-alpha	0,27	11beta-hydroxysteroid dehydrogenase type 1	Tumor necrosis factor-alpha	3290	7124	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha upregulates 11beta-hydroxysteroid_dehydrogenase_type_1 expression by CCAAT/enhancer _ binding_protein-beta in HepG2 cells .
10509802	0	11beta-hydroxysteroid_dehydrogenase_type_2	14,56	11betaHSD-2	58,69	11beta-hydroxysteroid dehydrogenase type 2	11betaHSD-2	3291	3291	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of 11beta-hydroxysteroid_dehydrogenase_type_2 -LRB- 11betaHSD-2 -RRB- in the developing human adrenal gland and human adrenal_cortical_carcinoma and adenoma .
12911547	0	11beta-hydroxysteroid_dehydrogenase_type_2	25,67	Angiotensin_II	0,14	11beta-hydroxysteroid dehydrogenase type 2	Angiotensin II	3291	183	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Angiotensin_II regulates 11beta-hydroxysteroid_dehydrogenase_type_2 via AT2 receptors .
23966319	0	11beta-hydroxysteroid_dehydrogenase_type_2	39,81	ERK1/2	4,10	11beta-hydroxysteroid dehydrogenase type 2	ERK1/2	3291	5595;5594	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The ERK1/2 signaling pathway regulates 11beta-hydroxysteroid_dehydrogenase_type_2 expression in human trophoblast cells through a transcriptional mechanism .
11916625	0	11beta-hydroxysteroid_dehydrogenase_type_2	61,103	HSD11B2	32,39	11beta-hydroxysteroid dehydrogenase type 2	HSD11B2	3291	3291	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association studies between the HSD11B2 gene -LRB- encoding human 11beta-hydroxysteroid_dehydrogenase_type_2 -RRB- , type_1_diabetes_mellitus and diabetic_nephropathy .
10509802	0	11betaHSD-2	58,69	11beta-hydroxysteroid_dehydrogenase_type_2	14,56	11betaHSD-2	11beta-hydroxysteroid dehydrogenase type 2	3291	3291	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of 11beta-hydroxysteroid_dehydrogenase_type_2 -LRB- 11betaHSD-2 -RRB- in the developing human adrenal gland and human adrenal_cortical_carcinoma and adenoma .
20967760	0	12/15-lipoxygenase	18,36	Alox15	43,49	12/15-lipoxygenase	Alox15	11687(Tax:10090)	11687(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of the 12/15-lipoxygenase gene -LRB- Alox15 -RRB- protects hyperlipidemic mice from nonalcoholic fatty liver_disease .
18296557	0	12/15-lipoxygenase	8,26	MCP-1	48,53	12/15-lipoxygenase	MCP-1	11687(Tax:10090)	20296(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages .
16166569	0	12/15-lipoxygenase	0,18	intercellular_adhesion_molecule-1	29,62	12/15-lipoxygenase	intercellular adhesion molecule-1	11687(Tax:10090)	15894(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	12/15-lipoxygenase regulates intercellular_adhesion_molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear_factor-kappaB .
1645936	0	125I-atrial_natriuretic_peptide	16,47	ANP	49,52	125I-atrial natriuretic peptide	ANP	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of 125I-atrial_natriuretic_peptide -LRB- ANP -RRB- in the rat fetus .
16943323	0	14-3-3	20,26	14-3-3zeta	36,46	14-3-3	14-3-3zeta	36059(Tax:7227)	36059(Tax:7227)	Gene	Gene	protein|nummod|START_ENTITY protein|amod|END_ENTITY	A novel function of 14-3-3 protein : 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins .
17700517	0	14-3-3	107,113	ASK1	119,123	14-3-3	ASK1	10971	4217	Gene	Gene	dissociating|dobj|START_ENTITY dissociating|nmod|END_ENTITY	G1 to S phase transition protein 1 induces apoptosis_signal-regulating_kinase_1 activation by dissociating 14-3-3 from ASK1 .
14966136	0	14-3-3	21,27	CD81	0,4	14-3-3	CD81	10971	975	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner .
22450169	0	14-3-3	30,36	Cofilin	0,7	14-3-3	Cofilin	10971	1072	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 -LRB- Hsp20 -RRB- .
26517365	0	14-3-3	17,23	Klotho	0,6	14-3-3	Klotho	10971	9365	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	Klotho Regulates 14-3-3 Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress .
22575644	0	14-3-3	0,6	LKB1	22,26	14-3-3	LKB1	10971	6794	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function .
16822840	0	14-3-3	65,71	Microphthalmia-associated_transcription_factor	0,46	14-3-3	Microphthalmia-associated transcription factor	10971	4286	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Microphthalmia-associated_transcription_factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors .
14653998	0	14-3-3	37,43	Par3	68,72	14-3-3	Par3	10971	56288	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia .
11985497	0	14-3-3	20,26	RGS3	0,4	14-3-3	RGS3	10971	5998	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS -LRB- regulator_of_G-protein_signalling -RRB- domain .
22027839	0	14-3-3	25,31	RGS3	104,108	14-3-3	RGS3	10971	5998	Gene	Gene	inhibition|nummod|START_ENTITY basis|nmod|inhibition basis|nmod|function function|appos|END_ENTITY	Structural basis for the 14-3-3 protein-dependent inhibition of the regulator_of_G_protein_signaling_3 -LRB- RGS3 -RRB- function .
7760835	0	14-3-3	0,6	Raf-1	28,33	14-3-3	Raf-1	10971	397857(Tax:8355)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|function function|compound|END_ENTITY	14-3-3 is not essential for Raf-1 function : identification of Raf-1 proteins that are biologically activated in a 14-3-3 - and Ras-independent manner .
25556369	0	14-3-3	0,6	Stat3	43,48	14-3-3	Stat3	10971	6774	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|nmod|Signaling Signaling|compound|END_ENTITY	14-3-3 Regulates Immune Response through Stat3 Signaling in Oral_Squamous_Cell_Carcinoma .
25754151	0	14-3-3	0,6	Stat3	43,48	14-3-3	Stat3	10971	6774	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|nmod|Signaling Signaling|compound|END_ENTITY	14-3-3 Regulates Immune Response through Stat3 Signaling in Oral_Squamous_Cell_Carcinoma .
21827211	0	14-3-3	50,56	TLR2	60,64	14-3-3	TLR2	10971	7097	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Identification and functional characterization of 14-3-3 in TLR2 signaling .
21302295	0	14-3-3	47,53	Tiam1	0,5	14-3-3	Tiam1	10971	7074	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Tiam1 is recruited to b1-integrin complexes by 14-3-3 where it mediates integrin-induced Rac1 activation and motility .
25266655	0	14-3-3	117,123	ULK1	92,96	14-3-3	ULK1	10971	8408	Gene	Gene	Interaction|amod|START_ENTITY Interaction|amod|END_ENTITY	Metabolic-Stress-Induced Rearrangement of the 14-3-3 Interactome Promotes Autophagy via a ULK1 - and AMPK-Regulated 14-3-3 Interaction with Phosphorylated Atg9 .
25516596	0	14-3-3	0,6	a1B	47,50	14-3-3	a1B	10971	1	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	14-3-3 Promotes Surface Expression of Cav2 .2 -LRB- a1B -RRB- Ca2 + Channels .
24923353	0	14-3-3	0,6	heat_shock_protein_70	17,38	14-3-3	heat shock protein 70	10971	3308	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	14-3-3 induces heat_shock_protein_70 expression in hepatocellular_carcinoma .
9111084	0	14-3-3	0,6	insulin-like_growth_factor_I_receptor	36,73	14-3-3	insulin-like growth factor I receptor	10971	3480	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	14-3-3 -LRB- epsilon -RRB- interacts with the insulin-like_growth_factor_I_receptor and insulin_receptor substrate I in a phosphoserine-dependent manner .
18812399	0	14-3-3	0,6	p53	36,39	14-3-3	p53	10971	7157	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers .
20206173	0	14-3-3	41,47	p53	17,20	14-3-3	p53	10971	7157	Gene	Gene	bound|nmod|START_ENTITY C-terminus|acl|bound C-terminus|compound|END_ENTITY	Structure of the p53 C-terminus bound to 14-3-3 : implications for stabilization of the p53 tetramer .
20206173	0	14-3-3	41,47	p53	87,90	14-3-3	p53	10971	7157	Gene	Gene	bound|nmod|START_ENTITY C-terminus|acl|bound Structure|nmod|C-terminus Structure|dep|implications implications|nmod|stabilization stabilization|nmod|tetramer tetramer|compound|END_ENTITY	Structure of the p53 C-terminus bound to 14-3-3 : implications for stabilization of the p53 tetramer .
22192357	0	14-3-3	0,6	p53	23,26	14-3-3	p53	10971	7157	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	14-3-3 regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast_cancer cells via Akt inactivation .
25670079	0	14-3-3	0,6	p53	138,141	14-3-3	p53	10971	7157	Gene	Gene	Turns|nsubj|START_ENTITY Turns|nmod|Changes Changes|nmod|Partners Partners|nmod|END_ENTITY	14-3-3 Turns TGF-b 's Function from Tumor Suppressor to Metastasis Promoter in Breast_Cancer by Contextual Changes of Smad Partners from p53 to Gli2 .
22279540	0	14-3-3	0,6	stat3	24,29	14-3-3	stat3	10971	6774	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	14-3-3 interacts with stat3 and regulates its constitutive activation in multiple myeloma cells .
21960009	0	14-3-3_epsilon	98,112	GFAP	134,138	14-3-3 epsilon	GFAP	22627(Tax:10090)	14580(Tax:10090)	Gene	Gene	increase|amod|START_ENTITY increase|nmod|END_ENTITY	A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3_epsilon and late increase of GFAP .
12855191	0	14-3-3_eta	19,29	IGF-I	49,54	14-3-3 eta	IGF-I	22629(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of 14-3-3_eta gene expression by IGF-I in mouse cerebellum during postnatal development .
8812417	0	14-3-3_eta	64,74	YWHAH	87,92	14-3-3 eta	YWHAH	7533	7533	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural organization and chromosomal assignment of the human 14-3-3_eta chain gene -LRB- YWHAH -RRB- .
16271083	0	14-3-3_sigma	11,23	estrogen_receptor_alpha	50,73	14-3-3 sigma	estrogen receptor alpha	2810	2099	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Increasing 14-3-3_sigma expression with declining estrogen_receptor_alpha and estrogen-responsive_finger_protein expression defines malignant progression of endometrial_carcinoma .
18472156	0	14-3-3_zeta	67,78	Bax	45,48	14-3-3 zeta	Bax	7534	581	Gene	Gene	dissociation|nmod|START_ENTITY dissociation|compound|END_ENTITY	PKC_delta in preeclamptic placentas promotes Bax dissociation from 14-3-3_zeta through 14-3-3_zeta phosphorylation .
18339856	0	14-3-3_zeta	0,11	p53	27,30	14-3-3 zeta	p53	7534	7157	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	14-3-3_zeta down-regulates p53 in mammary epithelial cells and confers luminal filling .
9261098	0	14-3-3_zeta	0,11	raf-1	33,38	14-3-3 zeta	raf-1	7534	5894	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	14-3-3_zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain .
17032734	0	14-3-3gamma	0,11	GFAP	91,95	14-3-3gamma	GFAP	7532	2670	Gene	Gene	affects|nsubj|START_ENTITY affects|nmod|END_ENTITY	14-3-3gamma affects dynamics and integrity of glial filaments by binding to phosphorylated GFAP .
12730952	0	14-3-3gamma	0,11	Raf	76,79	14-3-3gamma	Raf	7532	22882	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	14-3-3gamma is upregulated by in vitro ischemia and binds to protein kinase Raf in primary cultures of astrocytes .
10486217	0	14-3-3gamma	58,69	YWHAG	76,81	14-3-3gamma	YWHAG	7532	7532	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning , expression , and chromosomal mapping of the human 14-3-3gamma gene -LRB- YWHAG -RRB- to 7q11 .23 .
15332997	0	14-3-3sigma	137,148	p21	161,164	14-3-3sigma	p21	2810	1026	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Computerized video time lapse study of cell cycle delay and arrest , mitotic catastrophe , apoptosis and clonogenic survival in irradiated 14-3-3sigma and CDKN1A -LRB- p21 -RRB- knockout cell lines .
16532026	0	14-3-3sigma	30,41	p27_Kip1	53,61	14-3-3sigma	p27 Kip1	2810	1027	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Negative cell cycle regulator 14-3-3sigma stabilizes p27_Kip1 by inhibiting the activity of PKB/Akt .
17672938	0	14-3-3sigma	11,22	p73	54,57	14-3-3sigma	p73	2810	7161	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of 14-3-3sigma on transcriptional activity of p73 gene -RSB- .
16943323	0	14-3-3zeta	36,46	14-3-3	20,26	14-3-3zeta	14-3-3	36059(Tax:7227)	36059(Tax:7227)	Gene	Gene	protein|amod|START_ENTITY protein|nummod|END_ENTITY	A novel function of 14-3-3 protein : 14-3-3zeta is a heat-shock-related molecular chaperone that dissolves thermal-aggregated proteins .
22202082	0	14-3-3zeta	0,10	Plk1	42,46	14-3-3zeta	Plk1	7534	5347	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	14-3-3zeta cooperates with phosphorylated Plk1 and is required for correct cytokinesis .
18593902	0	15-Hydroxyprostaglandin_dehydrogenase	0,37	hepatocyte_nuclear_factor_3beta	53,84	15-Hydroxyprostaglandin dehydrogenase	hepatocyte nuclear factor 3beta	873	3170	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	15-Hydroxyprostaglandin_dehydrogenase is a target of hepatocyte_nuclear_factor_3beta and a tumor suppressor in lung_cancer .
15165036	0	15-LOX-1	0,8	p21	18,21	15-LOX-1	p21	246	1026	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	15-LOX-1 inhibits p21 -LRB- Cip/WAF _ 1 -RRB- expression by enhancing MEK-ERK_1 / 2 signaling in colon_carcinoma cells .
15247906	0	15-LOX2	144,151	15-lipoxygenase_2	125,142	15-LOX2	15-lipoxygenase 2	247	247	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase_2 -LRB- 15-LOX2 -RRB- gene expression in normal human prostate epithelial cells .
21763448	0	15-PGDH	53,60	15-hydroxyprostaglandin_dehydrogenase	14,51	15-PGDH	15-hydroxyprostaglandin dehydrogenase	3248	873	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of 15-hydroxyprostaglandin_dehydrogenase -LRB- 15-PGDH -RRB- by non-steroidal anti-inflammatory drugs -LRB- NSAIDs -RRB- .
24699315	0	15-PGDH	15,22	miR-21	0,6	15-PGDH	miR-21	3248	406991	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth .
21763448	0	15-hydroxyprostaglandin_dehydrogenase	14,51	15-PGDH	53,60	15-hydroxyprostaglandin dehydrogenase	15-PGDH	873	3248	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of 15-hydroxyprostaglandin_dehydrogenase -LRB- 15-PGDH -RRB- by non-steroidal anti-inflammatory drugs -LRB- NSAIDs -RRB- .
15531523	0	15-hydroxyprostaglandin_dehydrogenase	14,51	PGDH	53,57	15-hydroxyprostaglandin dehydrogenase	PGDH	873	3248	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of 15-hydroxyprostaglandin_dehydrogenase -LRB- PGDH -RRB- gene activity , messenger ribonucleic acid processing , and protein abundance in the human chorion in late gestation and labor .
26068950	0	15-hydroxyprostaglandin_dehydrogenase	52,89	miR-620	0,7	15-hydroxyprostaglandin dehydrogenase	miR-620	873	693205	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin_dehydrogenase -LRB- HPGD -RRB- .
26531105	0	15-kDa_selenoprotein	13,33	Sep15	35,40	15-kDa selenoprotein	Sep15	9403	9403	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Knockdown of 15-kDa_selenoprotein -LRB- Sep15 -RRB- increases hLE cells ' susceptibility to tunicamycin-induced apoptosis .
9822675	0	15-lipoxygenase	13,28	IL-13	43,48	15-lipoxygenase	IL-13	246	3596	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes .
12748293	0	15-lipoxygenase	28,43	Interleukin-13	0,14	15-lipoxygenase	Interleukin-13	246	3596	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Interleukin-13 induction of 15-lipoxygenase gene expression requires p38_mitogen-activated_protein_kinase-mediated serine 727 phosphorylation of Stat1 and Stat3 .
9870918	0	15-lipoxygenase	23,38	Interleukin-4	0,13	15-lipoxygenase	Interleukin-4	246	3565	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15 -LRB- S -RRB- - HETE into cellular phospholipids in cultured pulmonary epithelial cells .
16675443	0	15-lipoxygenase-1	22,39	Interleukin-4	0,13	15-lipoxygenase-1	Interleukin-4	246	3565	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves_disease .
15247906	0	15-lipoxygenase_2	125,142	15-LOX2	144,151	15-lipoxygenase 2	15-LOX2	247	247	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate functional tumor suppressor 15-lipoxygenase_2 -LRB- 15-LOX2 -RRB- gene expression in normal human prostate epithelial cells .
20635443	0	15-prostaglandin_dehydrogenase	39,69	cytosolic_phospholipase_A2	11,37	15-prostaglandin dehydrogenase	cytosolic phospholipase A2	3248	5321	Gene	Gene	expressions|amod|START_ENTITY expressions|amod|END_ENTITY	Impacts of cytosolic_phospholipase_A2 , 15-prostaglandin_dehydrogenase , and cyclooxygenase-2 expressions on tumor progression in colorectal_cancer .
25092292	0	16-2	8,12	miR-15b	0,7	16-2	miR-15b	3544	406949	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	miR-15b / 16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung .
8125484	0	17_beta-hydroxysteroid_dehydrogenase	81,117	EDH17B2	126,133	17 beta-hydroxysteroid dehydrogenase	EDH17B2	51478	3292	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human familial and sporadic_breast_cancer : analysis of the coding regions of the 17_beta-hydroxysteroid_dehydrogenase 2 gene -LRB- EDH17B2 -RRB- using a single-strand conformation polymorphism assay .
2173625	0	17_beta-hydroxysteroid_dehydrogenase	8,44	estradiol_receptor	74,92	17 beta-hydroxysteroid dehydrogenase	estradiol receptor	364773(Tax:10116)	24890(Tax:10116)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Role of 17_beta-hydroxysteroid_dehydrogenase in the modulation of nuclear estradiol_receptor binding by progesterone in the rat anterior pituitary gland and the uterus .
8614400	0	17_beta-hydroxysteroid_dehydrogenase_type_1	43,86	EDH17B2	93,100	17 beta-hydroxysteroid dehydrogenase type 1	EDH17B2	3292	3292	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Coordination of transcription of the human 17_beta-hydroxysteroid_dehydrogenase_type_1 gene -LRB- EDH17B2 -RRB- by a cell-specific enhancer and a silencer : identification of a retinoic_acid response element .
17583490	0	17beta-hydroxysteroid_dehydrogenase	47,82	C/EBPbeta	91,100	17beta-hydroxysteroid dehydrogenase	C/EBPbeta	7923	1051	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of the human type 8 17beta-hydroxysteroid_dehydrogenase gene by C/EBPbeta .
9709959	0	17beta-hydroxysteroid_dehydrogenase	68,103	HSD17B3	112,119	17beta-hydroxysteroid dehydrogenase	HSD17B3	345275	3293	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deleterious missense mutations and silent polymorphism in the human 17beta-hydroxysteroid_dehydrogenase 3 gene -LRB- HSD17B3 -RRB- .
11070349	0	17beta-hydroxysteroid_dehydrogenase_type_1	38,80	Activin-A	0,9	17beta-hydroxysteroid dehydrogenase type 1	Activin-A	25322(Tax:10116)	29200(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Activin-A , but not inhibin , regulates 17beta-hydroxysteroid_dehydrogenase_type_1 activity and expression in cultured rat granulosa cells .
19533843	0	17beta-hydroxysteroid_dehydrogenase_type_12	30,73	SREBP-1	77,84	17beta-hydroxysteroid dehydrogenase type 12	SREBP-1	51144	6720	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of 17beta-hydroxysteroid_dehydrogenase_type_12 by SREBP-1 .
6819151	0	20_alpha-hydroxysteroid_dehydrogenase	0,37	interleukin_3	102,115	20 alpha-hydroxysteroid dehydrogenase	interleukin 3	105349(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	20_alpha-hydroxysteroid_dehydrogenase expression in hemopoietic cell cultures and its relationship to interleukin_3 .
313949	0	20_alpha_hydroxysteroid_dehydrogenase	0,37	SDH	48,51	20 alpha hydroxysteroid dehydrogenase	SDH	105349(Tax:10090)	231691(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	20_alpha_hydroxysteroid_dehydrogenase -LRB- 20 alpha SDH -RRB- activity in New Zealand mice T lymphocytes and bone marrow cells : effect of age , sex , and castration .
15494462	0	20alpha-hydroxysteroid_dehydrogenase	27,63	AKR1C1	65,71	20alpha-hydroxysteroid dehydrogenase	AKR1C1	1645	1645	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and activity of 20alpha-hydroxysteroid_dehydrogenase -LRB- AKR1C1 -RRB- in abdominal subcutaneous and omental adipose tissue in women .
2109953	0	21-hydroxylase	18,32	CYP21	39,44	21-hydroxylase	CYP21	13079(Tax:10090)	403337(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The swine steroid 21-hydroxylase gene -LRB- CYP21 -RRB- : cloning and mapping within the swine leucocyte antigen complex .
8385740	0	21-hydroxylase	49,63	Cyp21	65,70	21-hydroxylase	Cyp21	13079(Tax:10090)	13079(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of promoter elements in the mouse 21-hydroxylase -LRB- Cyp21 -RRB- gene that require a functional cyclic_adenosine_3 ' ,5 ' - monophosphate-dependent protein kinase .
7814399	0	230-kDa_bullous_pemphigoid_antigen	63,97	BPAG1	104,109	230-kDa bullous pemphigoid antigen	BPAG1	667	667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interferon-gamma-mediated inactivation of transcription of the 230-kDa_bullous_pemphigoid_antigen gene -LRB- BPAG1 -RRB- provides novel insight into keratinocyte differentiation .
11282560	0	24P3	22,26	Interleukin-9	0,13	24P3	Interleukin-9	16819(Tax:10090)	16198(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-9 induces 24P3 lipocalin gene expression in murine T_cell_lymphomas .
15498883	0	25-hydroxyvitamin_D-24-hydroxylase	115,149	Cyp24a1	151,158	25-hydroxyvitamin D-24-hydroxylase	Cyp24a1	13081(Tax:10090)	13081(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin _ D3 and 25-hydroxyvitamin_D3 in the blood and tissues of the 25-hydroxyvitamin_D-24-hydroxylase -LRB- Cyp24a1 -RRB- null mouse .
14765994	0	25-hydroxyvitamin_D3-24-hydroxylase	44,79	CYP24	81,86	25-hydroxyvitamin D3-24-hydroxylase	CYP24	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Calcitonin stimulates expression of the rat 25-hydroxyvitamin_D3-24-hydroxylase -LRB- CYP24 -RRB- promoter in HEK-293 cells expressing calcitonin receptor : identification of signaling pathways .
12386916	0	25-hydroxyvitamin_D3_1-alpha-hydroxylase	31,71	CYP27B1	73,80	25-hydroxyvitamin D3 1-alpha-hydroxylase	CYP27B1	1594	1594	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence variants in the human 25-hydroxyvitamin_D3_1-alpha-hydroxylase -LRB- CYP27B1 -RRB- gene are not associated with prostate_cancer risk .
18824219	0	26RFa	48,53	GPR103	80,86	26RFa	GPR103	379044(Tax:10116)	310327(Tax:10116)	Gene	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Analgesic effects of intrathecally administered 26RFa , an intrinsic agonist for GPR103 , on formalin test and carrageenan test in rats .
7980651	0	2B1/2	39,44	cytochrome_P450	23,38	2B1/2	cytochrome P450	286954(Tax:10116)	25251(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Biphasic regulation of cytochrome_P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel .
16904757	0	2B4	27,30	CD16	15,19	2B4	CD16	51744	2214	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|nmod|+ +|compound|END_ENTITY	Persistence of CD16 + / CD56 - / 2B4 + natural killer cells : a highly dysfunctional NK subset expanded in ocular myasthenia_gravis .
15850375	0	2B4	50,53	CD244	55,60	2B4	CD244	51744	51744	Gene	Gene	receptor|dep|START_ENTITY receptor|appos|END_ENTITY	NMR structure of the natural killer cell receptor 2B4 -LRB- CD244 -RRB- : implications for ligand recognition .
15870174	0	2B4	0,3	CD48	12,16	2B4	CD48	18106(Tax:10090)	12506(Tax:10090)	Gene	Gene	START_ENTITY|dep|interactions interactions|nummod|END_ENTITY	2B4 -LRB- CD244 -RRB- - CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice .
9841922	0	2B4	0,3	CD48	95,99	2B4	CD48	51744	962	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	2B4 , the natural killer and T cell immunoglobulin superfamily surface protein , is a ligand for CD48 .
10854423	0	3-Methyladenine-DNA_glycosylase	0,31	MPG	33,36	3-Methyladenine-DNA glycosylase	MPG	4350	4350	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	3-Methyladenine-DNA_glycosylase -LRB- MPG protein -RRB- interacts with human RAD23 proteins .
19778996	0	3-Phosphoglycerate_dehydrogenase	0,32	HOXA10	60,66	3-Phosphoglycerate dehydrogenase	HOXA10	236539(Tax:10090)	15395(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	3-Phosphoglycerate_dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells .
25837481	0	3-hydroxy-3-methylglotaryl-coenzyme_A_reductase	40,87	HMGR	89,93	3-hydroxy-3-methylglotaryl-coenzyme A reductase	HMGR	3159	3159	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Erratum to : Bioinformatics study of the 3-hydroxy-3-methylglotaryl-coenzyme_A_reductase -LRB- HMGR -RRB- gene in Gramineae .
15473258	0	3-hydroxy-3-methylglutaryl-CoA_reductase	14,54	CuZn_superoxide_dismutase	74,99	3-hydroxy-3-methylglutaryl-CoA reductase	CuZn superoxide dismutase	3156	6647	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of 3-hydroxy-3-methylglutaryl-CoA_reductase gene expression by CuZn_superoxide_dismutase in human fibroblasts and HepG2 cells .
24732207	0	3-hydroxy-3-methylglutaryl-CoA_reductase	41,81	HMGCR	83,88	3-hydroxy-3-methylglutaryl-CoA reductase	HMGCR	3156	3156	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA_reductase -LRB- HMGCR -RRB- pathway : highlights from animal studies .
11716764	0	3-hydroxy-3-methylglutaryl-CoA_reductase	33,73	VCAM-1	95,101	3-hydroxy-3-methylglutaryl-CoA reductase	VCAM-1	3156	7412	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA_reductase on the expression of VCAM-1 and E-selectin in endothelial cells .
1522074	0	3-isopropylmalate_dehydrogenase	119,150	LEU2	157,161	3-isopropylmalate dehydrogenase	LEU2	850342(Tax:4932)	850342(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Directed mutagenesis in an asporogenous methylotrophic yeast : cloning , sequencing , and one-step gene disruption of the 3-isopropylmalate_dehydrogenase gene -LRB- LEU2 -RRB- of Candida boidinii to derive doubly auxotrophic marker strains .
18378410	0	3-phosphoglycerate_dehydrogenase	50,82	PHGDH	84,89	3-phosphoglycerate dehydrogenase	PHGDH	26227	26227	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Positive regulation of promoter activity of human 3-phosphoglycerate_dehydrogenase -LRB- PHGDH -RRB- gene is mediated by transcription factors Sp1 and NF-Y .
19429008	0	3-phosphoglycerate_dehydrogenase	26,58	Phgdh	60,65	3-phosphoglycerate dehydrogenase	Phgdh	26227	26227	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Selective upregulation of 3-phosphoglycerate_dehydrogenase -LRB- Phgdh -RRB- expression in adult subventricular zone neurogenic niche .
21930711	0	3-phosphoinositide-dependent_protein_kinase-1	133,178	MID1	56,60	3-phosphoinositide-dependent protein kinase-1	MID1	5170	4281	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Protein phosphatase 2A -LRB- PP2A -RRB- - specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent_protein_kinase-1 -LRB- PDPK-1 -RRB- .
18802401	0	3-phosphoinositide-dependent_protein_kinase-1	27,72	PDK1	74,78	3-phosphoinositide-dependent protein kinase-1	PDK1	18607(Tax:10090)	18607(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Dissecting the role of the 3-phosphoinositide-dependent_protein_kinase-1 -LRB- PDK1 -RRB- signalling pathways .
16150867	0	3-phosphoinositide-dependent_protein_kinase-1	0,45	peroxisome_proliferator-activated_receptor-gamma	60,108	3-phosphoinositide-dependent protein kinase-1	peroxisome proliferator-activated receptor-gamma	5163	5468	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	3-phosphoinositide-dependent_protein_kinase-1 activates the peroxisome_proliferator-activated_receptor-gamma and promotes adipocyte differentiation .
11087733	0	3-phosphoinositide-dependent_protein_kinase_1	0,45	Akt1	50,54	3-phosphoinositide-dependent protein kinase 1	Akt1	100774056	100769460	Gene	Gene	START_ENTITY|appos|kinase kinase|amod|END_ENTITY	3-phosphoinositide-dependent_protein_kinase_1 , an Akt1 kinase , is involved in dephosphorylation of Thr-308 of Akt1 in Chinese_hamster ovary cells .
15085180	0	300_kDa_mannose_6-phosphate_receptor	63,99	uPAR	13,17	300 kDa mannose 6-phosphate receptor	uPAR	3482	5329	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of uPAR , plasminogen , and sugar-binding sites of the 300_kDa_mannose_6-phosphate_receptor .
9846481	0	3BP2	57,61	IL-2	65,69	3BP2	IL-2	6452	3558	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation .
10825432	0	3G2	44,47	KDR	25,28	3G2	KDR	10180	3791	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro .
24639347	0	4-1BB	19,24	4-1BBL	25,31	4-1BB	4-1BBL	21942(Tax:10090)	21950(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|pathway pathway|nummod|END_ENTITY	Involvement of the 4-1BB / 4-1BBL pathway in control of monocyte numbers by invariant NKT cells .
12384425	0	4-1BB	8,13	CD137	15,20	4-1BB	CD137	3604	3604	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of 4-1BB -LRB- CD137 -RRB- in the functional activation of cord blood CD28 -LRB- - -RRB- CD8 -LRB- + -RRB- T cells .
12460192	0	4-1BB	13,18	CD137	20,25	4-1BB	CD137	3604	3604	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of 4-1BB -LRB- CD137 -RRB- expression by DNA damaging agents in human T lymphocytes .
12662292	0	4-1BB	21,26	CD137	14,19	4-1BB	CD137	3604	3604	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD137 -LRB- 4-1BB -RRB- on human follicular dendritic cells .
12706838	0	4-1BB	56,61	CD137	49,54	4-1BB	CD137	3604	3604	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	NF-kappaB and AP-1 regulate activation-dependent CD137 -LRB- 4-1BB -RRB- expression in T cells .
15308117	0	4-1BB	25,30	CD137	32,37	4-1BB	CD137	3604	3604	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Functional expression of 4-1BB -LRB- CD137 -RRB- in the inflammatory tissue in Crohn 's _ disease .
26587331	0	4-1BB	32,37	CD137	25,30	4-1BB	CD137	3604	3604	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Functional expression of CD137 -LRB- 4-1BB -RRB- on T helper follicular cells .
14707071	0	4-1BB	39,44	CD28	31,35	4-1BB	CD28	21942(Tax:10090)	12487(Tax:10090)	Gene	Gene	switch|nmod|START_ENTITY switch|nmod|END_ENTITY	A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo .
17878391	0	4-1BB	0,5	CD28	21,25	4-1BB	CD28	3604	940	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|END_ENTITY	4-1BB is superior to CD28 costimulation for generating CD8 + cytotoxic lymphocytes for adoptive immunotherapy .
18727631	0	4-1BB	10,15	CD4	30,33	4-1BB	CD4	3604	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Decreased 4-1BB expression on CD4 + CD25 high regulatory T cells in peripheral blood of patients with multiple_sclerosis .
11522228	0	4-1BB	25,30	CD8	67,70	4-1BB	CD8	3604	925	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Therapeutic potential of 4-1BB -LRB- CD137 -RRB- as a regulator for effector CD8 -LRB- + -RRB- T cells .
12356681	0	4-1BB	0,5	CD8	115,118	4-1BB	CD8	3604	925	Gene	Gene	co-stimulation|nmod:npmod|START_ENTITY enhances|dep|co-stimulation enhances|nsubj|CD8 CD8|dep|cell cell|acl|priming priming|advcl|augmenting augmenting|dobj|proliferation proliferation|nmod|T T|compound|END_ENTITY	4-1BB co-stimulation enhances human CD8 -LRB- + -RRB- T cell priming by augmenting the proliferation and survival of effector CD8 -LRB- + -RRB- T cells .
12356681	0	4-1BB	0,5	CD8	36,39	4-1BB	CD8	3604	925	Gene	Gene	co-stimulation|nmod:npmod|START_ENTITY enhances|dep|co-stimulation enhances|nsubj|END_ENTITY	4-1BB co-stimulation enhances human CD8 -LRB- + -RRB- T cell priming by augmenting the proliferation and survival of effector CD8 -LRB- + -RRB- T cells .
12391199	0	4-1BB	0,5	CD8	31,34	4-1BB	CD8	3604	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|nmod|lymphocytes lymphocytes|compound|END_ENTITY	4-1BB promotes the survival of CD8 + T lymphocytes by increasing expression of Bcl-xL and Bfl-1 .
12695569	0	4-1BB	55,60	CD8	9,12	4-1BB	CD8	3604	925	Gene	Gene	possess|nmod|START_ENTITY possess|nsubj|cells cells|compound|END_ENTITY	Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering .
12884287	0	4-1BB	0,5	CD8	15,18	4-1BB	CD8	3604	925	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expansion expansion|compound|END_ENTITY	4-1BB enhances CD8 + T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1 .
15270726	0	4-1BB	0,5	CD8	35,38	4-1BB	CD8	3604	925	Gene	Gene	enhance|nsubj|START_ENTITY enhance|dobj|responses responses|compound|END_ENTITY	4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime , poxvirus boost vaccine .
16488622	0	4-1BB	17,22	CD8	56,59	4-1BB	CD8	3604	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Cross-linking of 4-1BB up-regulates IL-13 expression in CD8 -LRB- + -RRB- T lymphocytes .
16524567	0	4-1BB	0,5	CD8	44,47	4-1BB	CD8	3604	925	Gene	Gene	costimulation|nummod|START_ENTITY enhances|nsubj|costimulation enhances|dobj|responses responses|compound|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
16524567	0	4-1BB	0,5	CD8	92,95	4-1BB	CD8	3604	925	Gene	Gene	costimulation|nummod|START_ENTITY enhances|nsubj|costimulation enhances|nmod|induction induction|nmod|cells cells|compound|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
17878391	0	4-1BB	0,5	CD8	55,58	4-1BB	CD8	3604	925	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|CD28 CD28|advcl|generating generating|dobj|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	4-1BB is superior to CD28 costimulation for generating CD8 + cytotoxic lymphocytes for adoptive immunotherapy .
18024793	0	4-1BB	0,5	CD8	56,59	4-1BB	CD8	3604	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|costimulation costimulation|nmod|cells cells|compound|END_ENTITY	4-1BB regulates NKG2D costimulation in human cord blood CD8 + T cells .
20722077	0	4-1BB	17,22	CD8	75,78	4-1BB	CD8	3604	925	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8 -LRB- + -RRB- T cells .
21742975	0	4-1BB	0,5	CD8	78,81	4-1BB	CD8	3604	925	Gene	Gene	synergizes|nummod|START_ENTITY ligand|nsubj|synergizes ligand|advcl|augment augment|dobj|responses responses|compound|END_ENTITY	4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral_infection .
22037570	0	4-1BB	21,26	CD8	80,83	4-1BB	CD8	3604	925	Gene	Gene	role|nmod|START_ENTITY role|nmod|cells cells|compound|END_ENTITY	Dispensable role for 4-1BB and 4-1BBL in development of vaccinia_virus-specific CD8 T cells .
23162550	0	4-1BB	10,15	CD8	35,38	4-1BB	CD8	3604	925	Gene	Gene	Targeting|dobj|START_ENTITY Targeting|advcl|enhance enhance|dobj|responses responses|compound|END_ENTITY	Targeting 4-1BB -LRB- CD137 -RRB- to enhance CD8 T cell responses with poxviruses and viral antigens .
23560068	0	4-1BB	23,28	CD8	74,77	4-1BB	CD8	3604	925	Gene	Gene	Co-stimulation|nmod|START_ENTITY Co-stimulation|parataxis|improves improves|dobj|expansion expansion|nmod|END_ENTITY	Co-stimulation through 4-1BB / CD137 improves the expansion and function of CD8 -LRB- + -RRB- melanoma_tumor-infiltrating lymphocytes for adoptive T-cell therapy .
25962156	0	4-1BB	0,5	CD8	71,74	4-1BB	CD8	3604	925	Gene	Gene	Primary|nummod|START_ENTITY Primary|nmod|T T|compound|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
26972770	0	4-1BB	0,5	CD8	71,74	4-1BB	CD8	3604	925	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|enhance enhance|dobj|+ +|compound|END_ENTITY	4-1BB signaling activates glucose and fatty_acid metabolism to enhance CD8 -LRB- + -RRB- T cell proliferation .
16488622	0	4-1BB	17,22	IL-13	36,41	4-1BB	IL-13	3604	3596	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Cross-linking of 4-1BB up-regulates IL-13 expression in CD8 -LRB- + -RRB- T lymphocytes .
10901161	0	4-1BB	41,46	c-jun_N-terminal_kinase	14,37	4-1BB	c-jun N-terminal kinase	3604	5599	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-jun_N-terminal_kinase by 4-1BB -LRB- CD137 -RRB- , a T cell co-stimulatory molecule .
24639347	0	4-1BBL	25,31	4-1BB	19,24	4-1BBL	4-1BB	21950(Tax:10090)	21942(Tax:10090)	Gene	Gene	pathway|nummod|START_ENTITY Involvement|dep|pathway Involvement|nmod|END_ENTITY	Involvement of the 4-1BB / 4-1BBL pathway in control of monocyte numbers by invariant NKT cells .
16970683	0	4-1BBL	32,38	4-1BB_ligand	18,30	4-1BBL	4-1BB ligand	8744	8744	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increased soluble 4-1BB_ligand -LRB- 4-1BBL -RRB- levels in peripheral blood of patients with multiple_sclerosis .
16970683	0	4-1BB_ligand	18,30	4-1BBL	32,38	4-1BB ligand	4-1BBL	8744	8744	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increased soluble 4-1BB_ligand -LRB- 4-1BBL -RRB- levels in peripheral blood of patients with multiple_sclerosis .
20871627	0	4-1BB_ligand	82,94	IL-15	64,69	4-1BB ligand	IL-15	8744	3600	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Immobilized MHC_class_I_chain-related_protein_A synergizes with IL-15 and soluble 4-1BB_ligand to expand NK cells with high cytotoxicity ex vivo .
7851880	0	4-hydroxyphenylpyruvic_acid_dioxygenase	23,62	HPD	69,72	4-hydroxyphenylpyruvic acid dioxygenase	HPD	3242	3242	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure of the human 4-hydroxyphenylpyruvic_acid_dioxygenase gene -LRB- HPD -RRB- .
7774914	0	4-hydroxyphenylpyruvic_acid_dioxygenase	27,66	Hpd	73,76	4-hydroxyphenylpyruvic acid dioxygenase	Hpd	15445(Tax:10090)	15445(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A nonsense mutation in the 4-hydroxyphenylpyruvic_acid_dioxygenase gene -LRB- Hpd -RRB- causes skipping of the constitutive exon and hypertyrosinemia in mouse_strain III .
17510058	0	4E-BP1	34,40	FOXO1	0,5	4E-BP1	FOXO1	1978	2308	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle .
19834456	0	4E-BP1	0,6	Smad4	22,27	4E-BP1	Smad4	1978	4089	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation .
16825247	0	4E-BP1	66,72	eIF4E	96,101	4E-BP1	eIF4E	1978	1977	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|interaction interaction|nmod|END_ENTITY	Effect of N-terminal region of eIF4E and Ser65-phosphorylation of 4E-BP1 on interaction between eIF4E and 4E-BP1 fragment peptide .
24975846	0	4E-BP1	79,85	eukaryotic_initiation_factor_4E	137,168	4E-BP1	eukaryotic initiation factor 4E	1978	1977	Gene	Gene	protein|appos|START_ENTITY dynamics|nmod|protein discordant|nsubj|dynamics discordant|nmod|potential potential|acl|interact interact|nmod|END_ENTITY	Phosphorylation dynamics of eukaryotic_initiation_factor_4E binding protein 1 -LRB- 4E-BP1 -RRB- is discordant with its potential to interact with eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- .
24975846	0	4E-BP1	79,85	eukaryotic_initiation_factor_4E	28,59	4E-BP1	eukaryotic initiation factor 4E	1978	1977	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Phosphorylation dynamics of eukaryotic_initiation_factor_4E binding protein 1 -LRB- 4E-BP1 -RRB- is discordant with its potential to interact with eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- .
21661078	0	4E-BP2	114,120	eIF4E	90,95	4E-BP2	eIF4E	1979	1977	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms : crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1 .
22684010	0	4E-BP3	0,6	replication_protein_A2	71,93	4E-BP3	replication protein A2	8637	6118	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication_protein_A2 .
19365557	0	4EHP	33,37	Prep1	12,17	4EHP	Prep1	326255(Tax:7227)	18771(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation .
9915839	0	4F2	0,3	CD98	5,9	4F2	CD98	17254(Tax:10090)	17254(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	4F2 -LRB- CD98 -RRB- heavy chain is associated covalently with an amino_acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer .
19617954	0	4F2_heavy_chain	62,77	4F2hc	79,84	4F2 heavy chain	4F2hc	6520	6520	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Significance of system L amino_acid transporter 1 -LRB- LAT-1 -RRB- and 4F2_heavy_chain -LRB- 4F2hc -RRB- expression in human developing intestines .
19068093	0	4F2_heavy_chain	70,85	CD98	87,91	4F2 heavy chain	CD98	6520	8140	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in early stage squamous cell carcinoma_of_the_lung .
19171406	0	4F2_heavy_chain	70,85	CD98	87,91	4F2 heavy chain	CD98	6520	8140	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in stage I pulmonary adenocarcinoma .
22993604	0	4F2_heavy_chain	70,85	CD98	87,91	4F2 heavy chain	CD98	6520	8140	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of L-type_amino_acid_transporter_1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in surgically resectable stage_III_non-small_cell_lung_cancer .
19617954	0	4F2hc	79,84	4F2_heavy_chain	62,77	4F2hc	4F2 heavy chain	6520	6520	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Significance of system L amino_acid transporter 1 -LRB- LAT-1 -RRB- and 4F2_heavy_chain -LRB- 4F2hc -RRB- expression in human developing intestines .
21750865	0	4F2hc	14,19	CD98	21,25	4F2hc	CD98	6520	6520	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of 4F2hc -LRB- CD98 -RRB- in pulmonary_neuroendocrine_tumors .
2889611	0	5-HT1A	58,64	5-hydroxytryptamine_1A	34,56	5-HT1A	5-hydroxytryptamine 1A	24473(Tax:10116)	24473(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Isapirone is a partial agonist at 5-hydroxytryptamine_1A -LRB- 5-HT1A -RRB- receptors in the rat hippocampus : electrophysiological evidence .
7472476	0	5-HT1A	33,39	CA1	58,61	5-HT1A	CA1	24473(Tax:10116)	310218(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|nmod|END_ENTITY	Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro .
10364698	0	5-HT1A	42,48	brain1	136,142	5-HT1A	brain1	24473(Tax:10116)	192109(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of experimental hypothyroidism on 5-HT1A , 5-HT2A receptors , 5-HT uptake sites and tryptophan_hydroxylase activity in mature rat brain1 .
20981413	0	5-HT1A_receptor	69,84	CA1	34,37	5-HT1A receptor	CA1	15550(Tax:10090)	12346(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY cells|nmod|mice cells|nummod|END_ENTITY	Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A_receptor knockout mice .
18499474	0	5-HT1A_receptor	15,30	HES1	0,4	5-HT1A receptor	HES1	3350	3280	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	HES1 regulates 5-HT1A_receptor gene transcription at a functional polymorphism : essential role in developmental expression .
1860872	0	5-HT1A_receptor	74,89	Protein_kinase_C	0,16	5-HT1A receptor	Protein kinase C	3350	112476	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Protein_kinase_C induces phosphorylation and desensitization of the human 5-HT1A_receptor .
26531356	0	5-HT1A_receptor	0,15	brain-derived_neurotrophic_factor	46,79	5-HT1A receptor	brain-derived neurotrophic factor	3350	627	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	5-HT1A_receptor gene in behavioral effects of brain-derived_neurotrophic_factor .
23118018	0	5-HT1B	32,38	5-hydroxytryptamine_1B	8,30	5-HT1B	5-hydroxytryptamine 1B	3351	3351	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Role of 5-hydroxytryptamine_1B -LRB- 5-HT1B -RRB- receptors in the regulation of ethanol intake in rodents .
10225363	0	5-HT1B	5,11	c-fos	42,47	5-HT1B	c-fos	25075(Tax:10116)	314322(Tax:10116)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis .
24246466	0	5-HT1B_receptor	0,15	serotonin_transporter	34,55	5-HT1B receptor	serotonin transporter	15551(Tax:10090)	15567(Tax:10090)	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	5-HT1B_receptor modulation of the serotonin_transporter in vivo : studies using KO mice .
8001977	0	5-HT1E	36,42	HTR1E	75,80	5-HT1E	HTR1E	3354	3354	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
8001977	0	5-HT1E	36,42	S31	63,66	5-HT1E	S31	3354	3354	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
9566028	0	5-HT2A	39,45	5-hydroxytryptamine_2A	15,37	5-HT2A	5-hydroxytryptamine 2A	29595(Tax:10116)	29595(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Involvement of 5-hydroxytryptamine_2A -LRB- 5-HT2A -RRB- receptors in the mediation of the discriminative stimulus properties of -LRB- + / - -RRB- DOI in rats .
12622403	0	5-HT2A	66,72	serotonin-2A_receptor	38,59	5-HT2A	serotonin-2A receptor	3356	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Family-based association study of the serotonin-2A_receptor gene -LRB- 5-HT2A -RRB- and bipolar_disorder .
7557992	0	5-HT2c	88,94	HTR2C	110,115	5-HT2c	HTR2C	3358	3358	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification , expression , and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene -LRB- HTR2C -RRB- .
10206229	0	5-HTT	28,33	Serotonin_transporter	0,21	5-HTT	Serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonin_transporter gene -LRB- 5-HTT -RRB- polymorphisms and compulsive buying .
20150867	0	5-HTT	32,37	serotonin_transporter	4,25	5-HTT	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The serotonin_transporter gene -LRB- 5-HTT -RRB- variant and psychiatric_disorders : review of current literature .
9603609	0	5-HTT	106,111	serotonin_transporter	78,99	5-HTT	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of a novel functional polymorphism within the promoter region of the serotonin_transporter gene -LRB- 5-HTT -RRB- in Brazilian patients affected by bipolar_disorder and schizophrenia .
23226060	0	5-HTTLPR	54,62	5-HTT_gene-linked_promoter_region	19,52	5-HTTLPR	5-HTT gene-linked promoter region	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of the 5-HTT_gene-linked_promoter_region -LRB- 5-HTTLPR -RRB- polymorphism with psychiatric_disorders : review of psychopathology and pharmacotherapy .
22931814	0	5-HTTLPR	16,24	DRD4	26,30	5-HTTLPR	DRD4	6532	1815	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|nummod|END_ENTITY	-LSB- Association of 5-HTTLPR , DRD4 gene polymorphisms with the accident tendentiousness of drivers -RSB- .
22268046	0	5-HTTLPR	27,35	SLC6A4	15,21	5-HTTLPR	SLC6A4	6532	6532	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Association of SLC6A4 gene 5-HTTLPR polymorphism with parameters of simple and complex reaction times and critical flicker frequency threshold in athletes during exhaustive exercise .
21852976	0	5-HTTLPR	40,48	Serotonin_Transporter	4,25	5-HTTLPR	Serotonin Transporter	6532	6532	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	The Serotonin_Transporter Polymorphism -LRB- 5-HTTLPR -RRB- and Alcohol_Problems in Heavy Drinkers : Moderation by Depressive Symptoms .
24130607	0	5-HTTLPR	36,44	Serotonin_Transporter	0,21	5-HTTLPR	Serotonin Transporter	6532	6532	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Serotonin_Transporter Polymorphism -LRB- 5-HTTLPR -RRB- and Citalopram Effectiveness in Iranian Patients with Major_Depressive_Disorder .
24578810	0	5-HTTLPR	39,47	Serotonin_Transporter	0,21	5-HTTLPR	Serotonin Transporter	6532	6532	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Serotonin_Transporter Promoter Region -LRB- 5-HTTLPR -RRB- Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation .
26186217	0	5-HTTLPR	82,90	Serotonin_Transporter	54,75	5-HTTLPR	Serotonin Transporter	6532	6532	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Adolescent Loneliness and the Interaction between the Serotonin_Transporter Gene -LRB- 5-HTTLPR -RRB- and Parental Support : A Replication Study .
26330209	0	5-HTTLPR	82,90	Serotonin_Transporter	46,67	5-HTTLPR	Serotonin Transporter	6532	6532	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Effects of Recent Stress and Variation in the Serotonin_Transporter Polymorphism -LRB- 5-HTTLPR -RRB- on Depressive Symptoms : A Repeated-Measures Study of Adults Age 50 and Older .
26464328	0	5-HTTLPR	12,20	Serotonin_Transporter	55,76	5-HTTLPR	Serotonin Transporter	6532	6532	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin_Transporter Gene Expression : a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants .
10395220	0	5-HTTLPR	28,36	Serotonin_transporter	0,21	5-HTTLPR	Serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonin_transporter gene -LRB- 5-HTTLPR -RRB- is not associated with depressive symptomatology in mood_disorders .
16091117	0	5-HTTLPR	41,49	Serotonin_transporter	0,21	5-HTTLPR	Serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- in patients with recurrent_aphthous_stomatitis .
17359932	0	5-HTTLPR	41,49	Serotonin_transporter	0,21	5-HTTLPR	Serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- in patients with oral_lichen_planus .
18315446	0	5-HTTLPR	36,44	Serotonin_transporter	0,21	5-HTTLPR	Serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Serotonin_transporter polymorphism -LRB- 5-HTTLPR -RRB- and citalopram effectiveness and side effects in children with depression and/or anxiety_disorders .
24408213	0	5-HTTLPR	50,58	Serotonin_transporter	0,21	5-HTTLPR	Serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Serotonin_transporter gene promoter polymorphism -LRB- 5-HTTLPR -RRB- and alcohol use in general population : interaction effect with birth cohort .
24558768	0	5-HTTLPR	28,36	Serotonin_transporter	0,21	5-HTTLPR	Serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Serotonin_transporter gene -LRB- 5-HTTLPR -RRB- polymorphism and efficacy of selective serotonin reuptake inhibitors -- do we have sufficient evidence for clinical practice .
26467894	0	5-HTTLPR	41,49	Serotonin_transporter	0,21	5-HTTLPR	Serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- L allele interacts with stress to increase anxiety_symptoms in Chinese adolescents : a multiwave longitudinal study .
10089017	0	5-HTTLPR	62,70	serotonin_transporter	39,60	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Neuroticism is not associated with the serotonin_transporter -LRB- 5-HTTLPR -RRB- polymorphism .
11343612	0	5-HTTLPR	68,76	serotonin_transporter	85,106	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Obsessive-compulsive_disorder and the promoter region polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter gene -LRB- SLC6A4 -RRB- : a negative association study in the Afrikaner population .
12962916	0	5-HTTLPR	98,106	serotonin_transporter	39,60	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Despite the general correlation of the serotonin_transporter gene regulatory region polymorphism -LRB- 5-HTTLPR -RRB- and platelet serotonin concentration , lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants .
14593433	0	5-HTTLPR	16,24	serotonin_transporter	33,54	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	A polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter promoter gene is associated with DSM-IV depression subtypes in seasonal_affective_disorder .
14966478	0	5-HTTLPR	88,96	serotonin_transporter	47,68	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	A meta-analysis of the association between the serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and trait anxiety .
15172105	0	5-HTTLPR	69,77	serotonin_transporter	41,62	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of evidence for association between serotonin_transporter gene -LRB- 5-HTTLPR -RRB- and obsessive-compulsive_disorder by case control and family association study in humans .
15691525	0	5-HTTLPR	74,82	serotonin_transporter	83,104	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	The power of sample size and homogenous sampling : association between the 5-HTTLPR serotonin_transporter polymorphism and major_depressive_disorder .
17216342	0	5-HTTLPR	87,95	serotonin_transporter	46,67	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Family based association analyses between the serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and neuroticism , anxiety and depression .
17728423	0	5-HTTLPR	53,61	serotonin_transporter	17,38	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Association of a serotonin_transporter polymorphism -LRB- 5-HTTLPR -RRB- with depression , perceived stress , and norepinephrine in patients with coronary_disease : the Heart and Soul Study .
18628678	0	5-HTTLPR	49,57	serotonin_transporter	21,42	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of the serotonin_transporter gene -LRB- 5-HTTLPR , A/G SNP in 5-HTTLPR , and STin2 VNTR -RRB- and their relation to personality traits in healthy individuals from Russia .
19125107	0	5-HTTLPR	14,22	serotonin_transporter	43,64	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Effect of the 5-HTTLPR polymorphism in the serotonin_transporter gene on major_depressive_disorder and related comorbid_disorders .
19209991	0	5-HTTLPR	69,77	serotonin_transporter	24,45	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Association between the serotonin_transporter promoter polymorphism -LRB- 5-HTTLPR -RRB- and adult unresolved attachment .
19252508	0	5-HTTLPR	28,36	serotonin_transporter	37,58	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Possible association of the 5-HTTLPR serotonin_transporter promoter gene polymorphism with premature_ejaculation in a Turkish population .
19439997	0	5-HTTLPR	52,60	serotonin_transporter	24,45	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between the serotonin_transporter gene -LRB- 5-HTTLPR -RRB- and anger-related traits in Korean schizophrenic patients .
19531786	0	5-HTTLPR	52,60	serotonin_transporter	24,45	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Interaction between the serotonin_transporter gene -LRB- 5-HTTLPR -RRB- , stressful life events , and risk of depression : a meta-analysis .
19699062	0	5-HTTLPR	45,53	serotonin_transporter	4,25	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	The serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and affective symptoms among women diagnosed with borderline_personality_disorder .
20598814	0	5-HTTLPR	38,46	serotonin_transporter	2,23	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	A serotonin_transporter polymorphism -LRB- 5-HTTLPR -RRB- predicts the development of adolescent alcohol use .
21142930	0	5-HTTLPR	52,60	serotonin_transporter	4,25	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	The serotonin_transporter gene length polymorphism -LRB- 5-HTTLPR -RRB- and life events : no evidence for an interaction effect on neuroticism and anxious_depressive_symptoms .
21562513	0	5-HTTLPR	25,33	serotonin_transporter	42,63	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Functional polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter gene is associated with subjective well-being : evidence from a US nationally representative sample .
22032950	0	5-HTTLPR	37,45	serotonin_transporter	14,35	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	The impact of serotonin_transporter -LRB- 5-HTTLPR -RRB- genotype on the development of resting-state functional connectivity in children and adolescents : a preliminary report .
22072907	0	5-HTTLPR	56,64	serotonin_transporter	20,41	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of human serotonin_transporter expression by 5-HTTLPR in colon cells .
23080078	0	5-HTTLPR	85,93	serotonin_transporter	44,65	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Relational security moderates the effect of serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- on stress generation and depression among adolescents .
23953022	0	5-HTTLPR	61,69	serotonin_transporter	20,41	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Working conditions , serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and anxiety_disorders : a prospective cohort study .
24015179	0	5-HTTLPR	59,67	serotonin_transporter	31,52	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	A functional polymorphism in a serotonin_transporter gene -LRB- 5-HTTLPR -RRB- interacts with 9/11 to predict gun-carrying behavior .
24098925	0	5-HTTLPR	4,12	serotonin_transporter	33,54	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	The 5-HTTLPR polymorphism in the serotonin_transporter gene moderates the association between emotional behavior and changes in marital satisfaction over time .
24512255	0	5-HTTLPR	45,53	serotonin_transporter	4,25	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	The serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and irritable_bowel_syndrome : a meta-analysis of 25 studies .
24842237	0	5-HTTLPR	103,111	serotonin_transporter	49,70	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Anxiety_disorders and anxiety-related_traits and serotonin_transporter gene-linked polymorphic region -LRB- 5-HTTLPR -RRB- in adolescents : case-control and trio studies .
25154585	0	5-HTTLPR	74,82	serotonin_transporter	20,41	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Interaction between serotonin_transporter gene-linked polymorphic region -LRB- 5-HTTLPR -RRB- and job-related stress in insomnia : a cross-sectional study in Sichuan , China .
26767356	0	5-HTTLPR	48,56	serotonin_transporter	20,41	5-HTTLPR	serotonin transporter	6532	6532	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|nmod|gene gene|compound|END_ENTITY	Polymorphism of the serotonin_transporter gene -LRB- 5-HTTLPR -RRB- in major depressive_disorder patients in Malaysia .
23226060	0	5-HTT_gene-linked_promoter_region	19,52	5-HTTLPR	54,62	5-HTT gene-linked promoter region	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of the 5-HTT_gene-linked_promoter_region -LRB- 5-HTTLPR -RRB- polymorphism with psychiatric_disorders : review of psychopathology and pharmacotherapy .
25446927	0	5-Hydroxytryptamine_1A	0,22	5HT1A	24,29	5-Hydroxytryptamine 1A	5HT1A	15550(Tax:10090)	15550(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	5-Hydroxytryptamine_1A -LRB- 5HT1A -RRB- receptors mediate increases in plasma glucose independent of corticosterone .
17484769	0	5-LOX	30,35	5-lipoxygenase	14,28	5-LOX	5-lipoxygenase	240	240	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of 5-lipoxygenase -LRB- 5-LOX -RRB- in T lymphocytes .
25025775	0	5-Lipoxygenase	0,14	FLAP	35,39	5-Lipoxygenase	FLAP	11689(Tax:10090)	11690(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	5-Lipoxygenase activating protein -LRB- FLAP -RRB- dependent leukotriene biosynthesis inhibition -LRB- MK591 -RRB- attenuates Lipid A endotoxin-induced inflammation .
9445303	0	5-Lipoxygenase	0,14	FLAP	54,58	5-Lipoxygenase	FLAP	240	241	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	5-Lipoxygenase and 5-lipoxygenase activating protein -LRB- FLAP -RRB- immunoreactivity in lungs from patients with primary_pulmonary_hypertension .
22257483	0	5-alpha-reductase	0,17	SRD5A1	26,32	5-alpha-reductase	SRD5A1	6715	6715	Gene	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	5-alpha-reductase type I -LRB- SRD5A1 -RRB- is up-regulated in non-small cell lung_cancer but does not impact proliferation , cell cycle distribution or apoptosis .
16098368	0	5-alpha_reductase	29,46	SRD5A2	60,66	5-alpha reductase	SRD5A2	6715	6716	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|appos|END_ENTITY	A novel missense mutation of 5-alpha_reductase type 2 gene -LRB- SRD5A2 -RRB- leads to severe male_pseudohermaphroditism in a Turkish family .
15123725	0	5-aminolevulinate_synthase	55,81	Hepatic_nuclear_factor_3	0,24	5-aminolevulinate synthase	Hepatic nuclear factor 3	211	2305	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Hepatic_nuclear_factor_3 and nuclear factor 1 regulate 5-aminolevulinate_synthase gene expression and are involved in insulin repression .
2889611	0	5-hydroxytryptamine_1A	34,56	5-HT1A	58,64	5-hydroxytryptamine 1A	5-HT1A	24473(Tax:10116)	24473(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Isapirone is a partial agonist at 5-hydroxytryptamine_1A -LRB- 5-HT1A -RRB- receptors in the rat hippocampus : electrophysiological evidence .
23118018	0	5-hydroxytryptamine_1B	8,30	5-HT1B	32,38	5-hydroxytryptamine 1B	5-HT1B	3351	3351	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Role of 5-hydroxytryptamine_1B -LRB- 5-HT1B -RRB- receptors in the regulation of ethanol intake in rodents .
9566028	0	5-hydroxytryptamine_2A	15,37	5-HT2A	39,45	5-hydroxytryptamine 2A	5-HT2A	29595(Tax:10116)	29595(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Involvement of 5-hydroxytryptamine_2A -LRB- 5-HT2A -RRB- receptors in the mediation of the discriminative stimulus properties of -LRB- + / - -RRB- DOI in rats .
17484769	0	5-lipoxygenase	14,28	5-LOX	30,35	5-lipoxygenase	5-LOX	240	240	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of 5-lipoxygenase -LRB- 5-LOX -RRB- in T lymphocytes .
20011686	0	5-lipoxygenase	27,41	ALOX5	48,53	5-lipoxygenase	ALOX5	25290(Tax:10116)	25290(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cardioprotective effect of 5-lipoxygenase gene -LRB- ALOX5 -RRB- silencing in ischemia-reperfusion .
12911785	0	5-lipoxygenase	29,43	ALOX5AP	91,98	5-lipoxygenase	ALOX5AP	240	241	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Promoter polymorphism in the 5-lipoxygenase -LRB- ALOX5 -RRB- and 5-lipoxygenase-activating protein -LRB- ALOX5AP -RRB- genes and asthma susceptibility in a Caucasian population .
23615158	0	5-lipoxygenase	26,40	CCL3	67,71	5-lipoxygenase	CCL3	11689(Tax:10090)	20302(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Atorvastatin inhibits the 5-lipoxygenase pathway and expression of CCL3 to alleviate atherosclerotic_lesions in atherosclerotic ApoE knockout mice .
11200053	0	5-lipoxygenase	155,169	CD69	123,127	5-lipoxygenase	CD69	240	969	Gene	Gene	pathway|amod|START_ENTITY eosinophils|nmod|pathway END_ENTITY|nmod|eosinophils	Pivotal role of 5-lipoxygenase in the activation of human eosinophils : platelet-activating_factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway .
11200053	0	5-lipoxygenase	16,30	CD69	123,127	5-lipoxygenase	CD69	240	969	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Pivotal role of 5-lipoxygenase in the activation of human eosinophils : platelet-activating_factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway .
26327594	0	5-lipoxygenase	45,59	FLAP	88,92	5-lipoxygenase	FLAP	240	241	Gene	Gene	interaction|nmod|START_ENTITY Characterization|nmod|interaction END_ENTITY|nsubj|Characterization	Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP .
7741044	0	5-lipoxygenase	115,129	FLAP	45,49	5-lipoxygenase	FLAP	240	241	Gene	Gene	regulation|nmod|START_ENTITY implications|nmod|regulation Mode|dep|implications Mode|nmod|action action|nmod|BAY_X_1005 BAY_X_1005|appos|END_ENTITY	Mode of action of the leukotriene synthesis -LRB- FLAP -RRB- inhibitor BAY_X_1005 : implications for biological regulation of 5-lipoxygenase .
8358016	0	5-lipoxygenase	41,55	GM-CSF	15,21	5-lipoxygenase	GM-CSF	240	1437	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Enhancement by GM-CSF of agonist-induced 5-lipoxygenase activation in human neutrophils involves protein synthesis and gene transcription .
7822663	0	5-lipoxygenase	31,45	MK-0591	14,21	5-lipoxygenase	MK-0591	240	1476692(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	The effect of MK-0591 , a novel 5-lipoxygenase activating protein inhibitor , on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo .
20970976	0	5-lipoxygenase	18,32	MK-0633	0,7	5-lipoxygenase	MK-0633	240	1476734(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	MK-0633 , a potent 5-lipoxygenase inhibitor , in chronic_obstructive_pulmonary_disease .
21945511	0	5-lipoxygenase	44,58	MK-0633	33,40	5-lipoxygenase	MK-0633	240	1476734(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	The efficacy and tolerability of MK-0633 , a 5-lipoxygenase inhibitor , in chronic_asthma .
8581424	0	5-lipoxygenase	114,128	cyclooxygenase_and_5-lipoxygenase	67,100	5-lipoxygenase	cyclooxygenase and 5-lipoxygenase	240	240	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Hydroxylamine analogs of 2,6-di-t-butylphenols : dual inhibitors of cyclooxygenase_and_5-lipoxygenase or selective 5-lipoxygenase inhibitors .
8665944	0	5-lipoxygenase	46,60	cytosolic_phospholipase_A2	18,44	5-lipoxygenase	cytosolic phospholipase A2	240	5321	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Colocalization of cytosolic_phospholipase_A2 , 5-lipoxygenase , and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils .
1728302	0	5-lipoxygenase	34,48	interferon-gamma	10,26	5-lipoxygenase	interferon-gamma	25290(Tax:10116)	25712(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Effect of interferon-gamma on the 5-lipoxygenase pathway of rat lung macrophages .
8142660	0	5-lipoxygenase	56,70	plasmin	83,90	5-lipoxygenase	plasmin	240	5340	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Contact activation triggers stimulation of the monocyte 5-lipoxygenase pathway via plasmin .
8349609	0	50-kDa	86,92	nuclear_factor_kappa_B	63,85	50-kDa	nuclear factor kappa B	18972(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Lipopolysaccharide stimulates both nuclear localization of the nuclear_factor_kappa_B 50-kDa subunit and loss of the 105-kDa precursor in RAW264 macrophage-like cells .
8012192	0	50_kDa_dystrophin-associated_glycoprotein	18,59	utrophin	87,95	50 kDa dystrophin-associated glycoprotein	utrophin	6442	7402	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Deficiency of the 50_kDa_dystrophin-associated_glycoprotein and abnormal expression of utrophin in two south Asian cousins with variable expression of severe childhood autosomal_recessive_muscular_dystrophy .
12668657	0	53BP1	37,42	Histone_deacetylase_4	0,21	53BP1	Histone deacetylase 4	7158	9759	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Histone_deacetylase_4 interacts with 53BP1 to mediate the DNA damage response .
24004175	0	53BP1	39,44	p53-binding_protein_1	16,37	53BP1	p53-binding protein 1	7158	7158	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Significance of p53-binding_protein_1 -LRB- 53BP1 -RRB- expression in thyroid_papillary_microcarcinoma : association with BRAFV600E mutation status .
22520477	0	53BP1	27,32	p53_binding_protein_1	4,25	53BP1	p53 binding protein 1	7158	7158	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Low p53_binding_protein_1 -LRB- 53BP1 -RRB- expression is associated with increased local recurrence in breast_cancer patients treated with breast-conserving surgery and radiotherapy .
19176521	0	53BP1	48,53	phosphatase_5	8,21	53BP1	phosphatase 5	7158	5536	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Protein phosphatase_5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage .
10498867	0	53BP2	31,36	p65	18,21	53BP2	p65	7159	5970	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2 .
9654073	0	58-kDa_microspherule_protein	4,32	p120	96,100	58-kDa microspherule protein	p120	10445	4839	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The 58-kDa_microspherule_protein -LRB- MSP58 -RRB- , a nucleolar protein , interacts with nucleolar protein p120 .
24361335	0	58-kda_microspherule_protein	4,32	telomerase_reverse_transcriptase	57,89	58-kda microspherule protein	telomerase reverse transcriptase	10445	7015	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	The 58-kda_microspherule_protein -LRB- MSP58 -RRB- represses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene expression and cell proliferation by interacting with telomerase_transcriptional_element-interacting_factor -LRB- TEIF -RRB- .
25446927	0	5HT1A	24,29	5-Hydroxytryptamine_1A	0,22	5HT1A	5-Hydroxytryptamine 1A	15550(Tax:10090)	15550(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	5-Hydroxytryptamine_1A -LRB- 5HT1A -RRB- receptors mediate increases in plasma glucose independent of corticosterone .
8333729	0	5HT1a_receptor	81,95	HTR1A	102,107	5HT1a receptor	HTR1A	3350	3350	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Segregation and linkage analysis in five manic_depression pedigrees excludes the 5HT1a_receptor gene -LRB- HTR1A -RRB- .
17987668	0	5HTT	20,24	SLC6A4	26,32	5HTT	SLC6A4	6532	6532	Gene	Gene	relationship|nmod|START_ENTITY relationship|appos|END_ENTITY	The relationship of 5HTT -LRB- SLC6A4 -RRB- methylation and genotype on mRNA expression and liability to major_depression and alcohol_dependence in subjects from the Iowa Adoption Studies .
25481722	0	5HTT	43,47	serotonin_transporter	15,36	5HTT	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of serotonin_transporter gene -LRB- 5HTT -RRB- polymorphism and juvenile_myoclonic_epilepsy : a case-control study .
25710844	0	5HTTLPR	78,85	SLC6A4	48,54	5HTTLPR	SLC6A4	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	A meta-analysis of the associations between the SLC6A4 promoter polymorphism -LRB- 5HTTLPR -RRB- and the risk for alcohol_dependence .
12090814	0	5HTTLPR	70,77	serotonin_transporter	20,41	5HTTLPR	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Association between serotonin_transporter gene promoter polymorphism -LRB- 5HTTLPR -RRB- and behavioral responses to tryptophan_depletion in healthy women with and without family history of depression .
11798178	0	5T4	0,3	TIP-2	19,24	5T4	TIP-2	7162	10755	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	5T4 interacts with TIP-2 / GIPC , a PDZ protein , with implications for metastasis .
8039530	0	5_alpha-reductase	101,118	MK-0434	82,89	5 alpha-reductase	MK-0434	6715	1477737(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434 , a steroid 5_alpha-reductase inhibitor , in healthy subjects .
8299317	0	5_alpha-reductase	35,52	MK-0963	20,27	5 alpha-reductase	MK-0963	6715	1477064(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	Pharmacodynamics of MK-0963 , a new 5_alpha-reductase inhibitor : effects on serum androgen concentrations .
9208814	0	5_alpha-reductase	80,97	SRD5A2	111,117	5 alpha-reductase	SRD5A2	6715	6716	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5_alpha-reductase type 2 gene -LRB- SRD5A2 -RRB- .
10081907	0	5alpha-reductase	65,81	SRD5A2	25,31	5alpha-reductase	SRD5A2	6715	6716	Gene	Gene	encoding|dobj|START_ENTITY locus|xcomp|encoding locus|nsubj|mutations mutations|nmod|END_ENTITY	Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate_cancer progression .
18268111	0	5alpha-reductase	25,41	SRD5A2	56,62	5alpha-reductase	SRD5A2	6715	6716	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	V89L polymorphism of the 5alpha-reductase Type II gene -LRB- SRD5A2 -RRB- , endogenous sex hormones , and prostate_cancer risk .
17657621	0	5alpha-reductase	50,66	TGF-beta	24,32	5alpha-reductase	TGF-beta	6715	7040	Gene	Gene	activity|amod|START_ENTITY effects|nmod|activity effects|nmod|END_ENTITY	The combined effects of TGF-beta , IGF and PDGF on 5alpha-reductase activity on androgen substrates in human gingival tissue .
10583164	0	5alpha-reductase	42,58	androgen_receptor	23,40	5alpha-reductase	androgen receptor	6715	367	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Expression of mRNA for androgen_receptor , 5alpha-reductase and 17beta-hydroxysteroid_dehydrogenase in human dermal_papilla cells .
6336317	0	6-PGD	47,52	6-phosphogluconate_dehydrogenase	13,45	6-PGD	6-phosphogluconate dehydrogenase	5226	5226	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The level of 6-phosphogluconate_dehydrogenase -LRB- 6-PGD -RRB- activity in a patient with 1p terminal deletion suggests that the gene locus is not distal to sub-band p36 .3 on chromosome 1 .
6336317	0	6-phosphogluconate_dehydrogenase	13,45	6-PGD	47,52	6-phosphogluconate dehydrogenase	6-PGD	5226	5226	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The level of 6-phosphogluconate_dehydrogenase -LRB- 6-PGD -RRB- activity in a patient with 1p terminal deletion suggests that the gene locus is not distal to sub-band p36 .3 on chromosome 1 .
14551150	0	6-pyruvoyltetrahydropterin_synthase	81,116	interleukin-1beta	17,34	6-pyruvoyltetrahydropterin synthase	interleukin-1beta	5805	3553	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of interleukin-1beta for transcriptional regulation of endothelial 6-pyruvoyltetrahydropterin_synthase .
23609452	0	60-kDa_Tat-interactive_protein	0,30	Th-inducing_POK	60,75	60-kDa Tat-interactive protein	Th-inducing POK	10524	51043	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	60-kDa_Tat-interactive_protein -LRB- TIP60 -RRB- positively regulates Th-inducing_POK -LRB- ThPOK -RRB- - mediated repression of eomesodermin in human CD4 + T cells .
10683318	0	67-kDa_laminin_receptor	38,61	67LR	63,67	67-kDa laminin receptor	67LR	3921	3921	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of membrane-associated 67-kDa_laminin_receptor -LRB- 67LR -RRB- is modulated in vitro by cell-contact inhibition .
20511545	0	67-kDa_laminin_receptor	101,124	TLR4	0,4	67-kDa laminin receptor	TLR4	3921	7099	Gene	Gene	polyphenol_epigallocatechin-3-gallate|advcl|START_ENTITY tea|amod|polyphenol_epigallocatechin-3-gallate induced|nmod|tea induced|nsubj|END_ENTITY	TLR4 signaling inhibitory pathway induced by green tea polyphenol_epigallocatechin-3-gallate through 67-kDa_laminin_receptor .
22960171	0	67-kDa_laminin_receptor	84,107	TLR4	57,61	67-kDa laminin receptor	TLR4	3921	7099	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Green tea polyphenol_epigallocatechin-3-gallate inhibits TLR4 signaling through the 67-kDa_laminin_receptor on lipopolysaccharide-stimulated dendritic cells .
25109435	0	67-kDa_laminin_receptor	65,88	TLR4	111,115	67-kDa laminin receptor	TLR4	3921	7099	Gene	Gene	negatively|amod|START_ENTITY negatively|acl|regulating regulating|dobj|END_ENTITY	Epigallocatechin-3-gallate-mediated Tollip induction through the 67-kDa_laminin_receptor negatively regulating TLR4 signaling in endothelial cells .
10683318	0	67LR	63,67	67-kDa_laminin_receptor	38,61	67LR	67-kDa laminin receptor	3921	3921	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of membrane-associated 67-kDa_laminin_receptor -LRB- 67LR -RRB- is modulated in vitro by cell-contact inhibition .
25732404	0	67_kDa_Laminin_Receptor	111,134	Toll-like_Receptor_4	70,90	67 kDa Laminin Receptor	Toll-like Receptor 4	3921	7099	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Epigallocatechin_Gallate -LRB- EGCG -RRB- Suppresses Lipopolysaccharide-Induced Toll-like_Receptor_4 -LRB- TLR4 -RRB- Activity via 67_kDa_Laminin_Receptor -LRB- 67LR -RRB- in 3T3-L1 Adipocytes .
10201891	0	6Ckine	119,125	CXCR3	106,111	6Ckine	CXCR3	6366	2833	Gene	Gene	ligand|nsubj|START_ENTITY Cutting|parataxis|ligand Cutting|parataxis|signaling signaling|nmod|END_ENTITY	Cutting edge : species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3 : human 6Ckine is not a ligand for the human or mouse CXCR3_receptors .
10201891	0	6Ckine	54,60	CXCR3	106,111	6Ckine	CXCR3	6366	2833	Gene	Gene	specificity|nmod|START_ENTITY signaling|nsubj|specificity signaling|nmod|END_ENTITY	Cutting edge : species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3 : human 6Ckine is not a ligand for the human or mouse CXCR3_receptors .
9653165	0	6Ckine	17,23	CXCR3	57,62	6Ckine	CXCR3	18829(Tax:10090)	12766(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3 .
8734434	0	70-kDa_heat_shock_cognate_protein	33,66	myelin_basic_protein	89,109	70-kDa heat shock cognate protein	myelin basic protein	24468(Tax:10116)	24547(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Antisense oligonucleotide to the 70-kDa_heat_shock_cognate_protein inhibits synthesis of myelin_basic_protein .
9521874	0	70-kDa_peroxisomal_membrane_protein	28,63	PXMP1	70,75	70-kDa peroxisomal membrane protein	PXMP1	5825	5825	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the 70-kDa_peroxisomal_membrane_protein gene -LRB- PXMP1 -RRB- .
9134100	0	72-kDa_gelatinase	14,31	matrix_metalloproteinase-2	33,59	72-kDa gelatinase	matrix metalloproteinase-2	17390(Tax:10090)	17390(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of 72-kDa_gelatinase -LRB- matrix_metalloproteinase-2 -RRB- in the developing mouse craniofacial complex .
25811241	0	7B2	44,47	Prohormone_Convertase_2	55,78	7B2	Prohormone Convertase 2	6447	5126	Gene	Gene	Activation|nummod|START_ENTITY Activation|compound|END_ENTITY	Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone_Convertase_2 Activation .
14709802	0	7B2	44,47	TGFbeta_1	67,76	7B2	TGFbeta 1	6447	7040	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cell growth and expression of 7B2 , PC2 , and PC1/3 by TGFbeta_1 and sodium_butyrate in a human pituitary cell line -LRB- HP75 -RRB- .
7880590	0	7B2	36,39	calcitonin_gene-related_peptide	64,95	7B2	calcitonin gene-related peptide	25719(Tax:10116)	24241(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Immunohistochemical distribution of 7B2 and colocalization with calcitonin_gene-related_peptide in rat lung .
15841414	0	8-oxoguanine_DNA_glycosylase	14,42	OGG1	44,48	8-oxoguanine DNA glycosylase	OGG1	4968	4968	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of 8-oxoguanine_DNA_glycosylase -LRB- OGG1 -RRB- in Parkinson 's _ disease and related neurodegenerative_disorders .
19503746	0	8-oxoguanine_DNA_glycosylase	14,42	Ogg1	44,48	8-oxoguanine DNA glycosylase	Ogg1	18294(Tax:10090)	18294(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of 8-oxoguanine_DNA_glycosylase -LRB- Ogg1 -RRB- in mouse retina .
16056251	0	8-oxoguanine_DNA_glycosylase	20,48	hOGG1	50,55	8-oxoguanine DNA glycosylase	hOGG1	4968	4968	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human 8-oxoguanine_DNA_glycosylase -LRB- hOGG1 -RRB- in follicular_lymphoma .
21727658	0	8-oxoguanine_DNA_glycosylase	105,133	hOGG1	135,140	8-oxoguanine DNA glycosylase	hOGG1	4968	4968	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Protective association exhibited by the single nucleotide polymorphism -LRB- SNP -RRB- rs1052133 in the gene human 8-oxoguanine_DNA_glycosylase -LRB- hOGG1 -RRB- with the risk of squamous_cell_carcinomas of the head _ neck -LRB- SCCHN -RRB- among north Indians .
16293709	0	8-oxoguanine_DNA_glycosylase	49,77	hOgg1	79,84	8-oxoguanine DNA glycosylase	hOgg1	4968	4968	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	The effect of p53-RNAi and p53 knockout on human 8-oxoguanine_DNA_glycosylase -LRB- hOgg1 -RRB- activity .
21925250	0	8-oxoguanine_DNA_glycosylase_1	49,79	extracellular_regulated_kinase	104,134	8-oxoguanine DNA glycosylase 1	extracellular regulated kinase	4968	5594	Gene	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Silver nanoparticles down-regulate Nrf2-mediated 8-oxoguanine_DNA_glycosylase_1 through inactivation of extracellular_regulated_kinase and protein_kinase_B in human Chang liver cells .
23368532	0	8-oxoguanine_glycosylase_1	67,93	OGG1	95,99	8-oxoguanine glycosylase 1	OGG1	4968	4968	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Is there any association between the Ser326Cys polymorphism of the 8-oxoguanine_glycosylase_1 -LRB- OGG1 -RRB- gene and risk of colon_polyp_and_abnormal_glucose_tolerance in acromegaly patients ?
1544410	0	80_kDa	33,39	MARCKS	41,47	80 kDa	MARCKS	13139(Tax:10090)	17118(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Multisite phosphorylation of the 80_kDa -LRB- MARCKS -RRB- protein kinase C substrate in C3H/10T1/2 fibroblasts .
8224813	0	87B	47,50	protein_phosphatase_1	17,38	87B	protein phosphatase 1	49260(Tax:7227)	49260(Tax:7227)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Mutations in the protein_phosphatase_1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila_melanogaster .
10606766	0	9-cis-retinol_dehydrogenase	26,53	ADHII	101,106	9-cis-retinol dehydrogenase	ADHII	366791(Tax:10116)	29646(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Analysis of rat cytosolic 9-cis-retinol_dehydrogenase activity and enzymatic characterization of rat ADHII .
11980646	0	90K	14,17	Mac-2_BP	19,27	90K	Mac-2 BP	3959	3959	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of 90K -LRB- Mac-2_BP -RRB- correlates with distant metastasis and predicts survival in stage I non-small_cell_lung_cancer patients .
18942707	0	90K	19,22	Mac-2_BP	24,32	90K	Mac-2 BP	3959	3959	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High expression of 90K -LRB- Mac-2_BP -RRB- is associated with poor survival in node-negative breast_cancer patients not receiving adjuvant systemic therapies .
12826680	0	9G8	88,91	ASF/SF2	93,100	9G8	ASF/SF2	6432	6426	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	The CD44 alternative v9 exon contains a splicing enhancer responsive to the SR proteins 9G8 , ASF/SF2 , and SRp20 .
19914667	0	A-1	65,68	apolipoprotein_B	45,61	A-1	apolipoprotein B	597	338	Gene	Gene	ratio|compound|START_ENTITY associated|nmod|ratio associated|nmod|END_ENTITY	Adiponectin is independently associated with apolipoprotein_B to A-1 ratio in Koreans .
19115207	0	A-FABP	0,6	PPAR	123,127	A-FABP	PPAR	2167	5465	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	A-FABP , a candidate progression marker of human transitional cell carcinoma_of_the_bladder , is differentially regulated by PPAR in urothelial_cancer cells .
19217286	0	A-FABP	117,123	adipocyte_fatty-acid_binding_protein	79,115	A-FABP	adipocyte fatty-acid binding protein	2167	2167	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	N-Benzyl-indolo_carboxylic_acids : Design and synthesis of potent and selective adipocyte_fatty-acid_binding_protein -LRB- A-FABP -RRB- inhibitors .
1770304	0	A-II	95,99	apolipoprotein_A-I	22,40	A-II	apolipoprotein A-I	114548	335	Gene	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|END_ENTITY	In vivo metabolism of apolipoprotein_A-I on high density lipoprotein particles LpA-I and LpA-I , A-II .
11279034	0	A-II	15,19	scavenger_receptor_BI	114,135	A-II	scavenger receptor BI	11847(Tax:10090)	20778(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Apolipoprotein A-II modulates the binding and selective lipid uptake of reconstituted high density lipoprotein by scavenger_receptor_BI .
15314084	0	A-LAP	58,63	adipocyte-derived_leucine_aminopeptidase	16,56	A-LAP	adipocyte-derived leucine aminopeptidase	51752	51752	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of adipocyte-derived_leucine_aminopeptidase -LRB- A-LAP -RRB- / ER-aminopeptidase _ -LRB- ERAP -RRB- -1 in human uterine endometrium .
21750041	0	A-MYB	0,5	MYBL1	7,12	A-MYB	MYBL1	4603	4603	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	A-MYB -LRB- MYBL1 -RRB- transcription factor is a master regulator of male meiosis .
8621729	0	A-Raf	45,50	MEK1	24,28	A-Raf	MEK1	369	5604	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Selective activation of MEK1 but not MEK2 by A-Raf from epidermal_growth_factor-stimulated Hela cells .
24572810	0	A-Raf	75,80	hnRNP_A2	16,24	A-Raf	hnRNP A2	369	3181	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Splicing factor hnRNP_A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular_carcinoma development .
15951119	0	A-kinase_anchoring_protein	41,67	CA1	91,94	A-kinase anchoring protein	CA1	171026(Tax:10116)	310218(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|cells cells|compound|END_ENTITY	Synaptic and subcellular localization of A-kinase_anchoring_protein 150 in rat hippocampal CA1 pyramidal cells : Co-localization with excitatory synaptic markers .
10420881	0	A-kinase_anchoring_protein	8,34	G_alpha_13	63,73	A-kinase anchoring protein	G alpha 13	11214	10672	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	A novel A-kinase_anchoring_protein in the heart interacts with G_alpha_13 .
18381233	0	A-kinase_anchoring_protein	0,26	TRPV1	36,41	A-kinase anchoring protein	TRPV1	498549(Tax:10116)	83810(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	A-kinase_anchoring_protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 .
15257753	0	A-kinase_anchoring_protein_3	37,65	sperm_protein_17	15,31	A-kinase anchoring protein 3	sperm protein 17	10566	53340	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of sperm_protein_17 with A-kinase_anchoring_protein_3 in flagella .
8634438	0	A-myb	14,19	c-myb	29,34	A-myb	c-myb	4603	4602	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of A-myb , but not c-myb and B-myb , is restricted to Burkitt 's _ lymphoma , sIg + B-acute_lymphoblastic_leukemia , and a subset of chronic_lymphocytic_leukemias .
8020955	0	A-raf-1	57,64	ARAF1	71,76	A-raf-1	ARAF1	369	369	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The complete sequence and promoter activity of the human A-raf-1 gene -LRB- ARAF1 -RRB- .
11526431	0	A1-a	49,53	Bcl-2	28,33	A1-a	Bcl-2	5265	596	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	Transient expression of the Bcl-2 family member , A1-a , results in nuclear localization and resistance to staurosporine-induced apoptosis .
19129404	0	A1/C1	62,67	Npy	26,29	A1/C1	Npy	6966	4852	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Simultaneous silencing of Npy and Dbh expression in hindbrain A1/C1 catecholamine cells suppresses glucoprivic feeding .
25056970	0	A11	8,11	ANXA11	13,19	A11	ANXA11	8248	311	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Annexin A11 -LRB- ANXA11 -RRB- gene polymorphisms are associated with sarcoidosis in a Han Chinese population : a case-control study .
7985993	0	A1BG	47,51	alpha-1-B-glycoprotein	23,45	A1BG	alpha-1-B-glycoprotein	1	1	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of plasma alpha-1-B-glycoprotein -LRB- A1BG -RRB- polymorphism in several populations of the Indian subcontinent .
8456628	0	A1PI	40,44	alpha-1-protease_inhibitor	12,38	A1PI	alpha-1-protease inhibitor	5265	5265	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of alpha-1-protease_inhibitor -LRB- A1PI -RRB- in the inhibition of protease activity in human knee_osteoarthritis .
26297794	0	A1a	14,17	CXCL8	41,46	A1a	CXCL8	5265	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Serum amyloid A1a induces paracrine IL-8 / CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils .
16684768	0	A20	51,54	ABIN-1	0,6	A20	ABIN-1	28935	10318	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB .
18349075	0	A20	0,3	BCL10	31,36	A20	BCL10	7128	8915	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activation activation|amod|END_ENTITY	A20 is a negative regulator of BCL10 - and CARMA3-mediated activation of NF-kappaB .
24487321	0	A20	60,63	DREAM	25,30	A20	DREAM	21929(Tax:10090)	56461(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation .
15661910	0	A20	0,3	IFN_regulatory_factor_3	31,54	A20	IFN regulatory factor 3	28935	3661	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	A20 is a negative regulator of IFN_regulatory_factor_3 signaling .
17709380	0	A20	58,61	IkappaB_kinase_beta	0,19	A20	IkappaB kinase beta	28935	3551	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	IkappaB_kinase_beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway .
21531730	0	A20	0,3	K13	103,106	A20	K13	7128	3860	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	A20 is induced by Kaposi_sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein -LRB- vFLIP -RRB- K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner .
26170170	0	A20	39,42	RC3H1	0,5	A20	RC3H1	28935	149041	Gene	Gene	mRNA|compound|START_ENTITY regulates|dobj|mRNA regulates|nsubj|END_ENTITY	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kB pathway .
19131965	0	A20	29,32	RNF11	42,47	A20	RNF11	7128	26994	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling .
25165885	0	A20	44,47	RNF114	22,28	A20	RNF114	28935	55905	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-kB activity and T-cell activation .
20822710	0	A20	34,37	TNFAIP3	25,32	A20	TNFAIP3	7128	7128	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Functional evaluation of TNFAIP3 -LRB- A20 -RRB- in rheumatoid_arthritis .
26199174	0	A20	34,37	TNFAIP3	25,32	A20	TNFAIP3	7128	7128	Gene	Gene	alterations|appos|START_ENTITY alterations|nmod|END_ENTITY	Recurrent alterations of TNFAIP3 -LRB- A20 -RRB- in T-cell_large_granular_lymphocytic_leukemia .
18952128	0	A20	24,27	TRAF2	36,41	A20	TRAF2	7128	7186	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation .
19378032	0	A20	23,26	Toll-like_receptor-4	53,73	A20	Toll-like receptor-4	7128	7099	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|stimulation stimulation|compound|END_ENTITY	Cellular expression of A20 and ABIN-3 in response to Toll-like_receptor-4 stimulation .
19912257	0	A20	0,3	Toll-like_receptor_5	49,69	A20	Toll-like receptor 5	7128	7100	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	A20 is an early responding negative regulator of Toll-like_receptor_5 signalling in intestinal epithelial cells during inflammation .
21095585	0	A20	21,24	ZnF4	25,29	A20	ZnF4	7128	7897	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kB signaling .
15142865	0	A20	0,3	toll-like_receptor_2	13,33	A20	toll-like receptor 2	7128	7097	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	A20 inhibits toll-like_receptor_2 - and 4-mediated interleukin-8 synthesis in airway epithelial cells .
1381359	0	A20	93,96	tumor_necrosis_factor	34,55	A20	tumor necrosis factor	7128	7124	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Transcriptional activation of the tumor_necrosis_factor alpha-inducible zinc finger protein , A20 , is mediated by kappa B elements .
16326701	0	A20	57,60	uracil_DNA_glycosylase	15,37	A20	uracil DNA glycosylase	28935	7374	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Vaccinia_virus uracil_DNA_glycosylase interacts with the A20 protein to form a heterodimeric processivity factor for the viral DNA polymerase .
16004874	0	A21	40,43	ICAM-1	69,75	A21	ICAM-1	28922	3383	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of coxsackievirus A21 and its interaction with ICAM-1 .
12242516	0	A24	83,86	CEA	36,39	A24	CEA	28924	1084	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Induction of specific CTL by MAGE-3 / CEA peptide-pulsed dendritic cells from HLA-A2 / A24 -LRB- + -RRB- gastrointestinal_cancer patients .
286291	0	A24	20,23	H2A	33,36	A24	H2A	28924	8337	Gene	Gene	replaces|nsubj|START_ENTITY replaces|dobj|END_ENTITY	Semihistone protein A24 replaces H2A as an integral component of the nucleosome histone core .
20484506	0	A27p	199,203	ATIp	151,155	A27p	ATIp	28912	57509	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Congregation of orthopoxvirus virions in cytoplasmic A-type inclusions is mediated by interactions of a bridging protein -LRB- A26p -RRB- with a matrix protein -LRB- ATIp -RRB- and a virion membrane-associated protein -LRB- A27p -RRB- .
10092821	0	A2B	27,30	IFN-gamma	0,9	A2B	IFN-gamma	11541(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY up-regulates|dep|expression up-regulates|amod|END_ENTITY	IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages : a mechanism of macrophage deactivation .
26317647	0	A2B	47,50	VEGF	78,82	A2B	VEGF	11541(Tax:10090)	22339(Tax:10090)	Gene	Gene	production|nummod|START_ENTITY production|compound|END_ENTITY	Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model .
16910174	0	A2M	55,58	alpha-2-macroglobulin	32,53	A2M	alpha-2-macroglobulin	2	2	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The genetic association between alpha-2-macroglobulin -LRB- A2M -RRB- gene deletion polymorphism and low serum A2M concentration in overweight/obese Thais .
9029412	0	A2aAR	30,35	adenosine_A2a_receptor	6,28	A2aAR	adenosine A2a receptor	135	135	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human adenosine_A2a_receptor -LRB- A2aAR -RRB- gene : systematic mutation screening in patients with schizophrenia .
21320567	0	A2b_adenosine_receptor	38,60	MMP-9	14,19	A2b adenosine receptor	MMP-9	11541(Tax:10090)	17395(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of MMP-9 expression by the A2b_adenosine_receptor and its dependency on TNF-a signaling .
12482500	0	A3_adenosine_receptor	16,37	G-CSF	45,50	A3 adenosine receptor	G-CSF	11542(Tax:10090)	12985(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Agonists to the A3_adenosine_receptor induce G-CSF production via NF-kappaB activation : a new class of myeloprotective agents .
15332344	0	AA-NAT	60,66	arylalkylamine-N-acetyl-transferase	23,58	AA-NAT	arylalkylamine-N-acetyl-transferase	15	15	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variability of arylalkylamine-N-acetyl-transferase -LRB- AA-NAT -RRB- gene and human sleep/wake pattern .
23284853	0	AA-NAT	138,144	arylalkylamine-N-acetyltransferase	102,136	AA-NAT	arylalkylamine-N-acetyltransferase	11298(Tax:10090)	11298(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	NF-kB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase -LRB- AA-NAT -RRB- gene .
12736803	0	AA-NAT	68,74	arylalkylamine_N-acetyltransferase	31,65	AA-NAT	arylalkylamine N-acetyltransferase	15	15	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Significant association of the arylalkylamine_N-acetyltransferase -LRB- AA-NAT -RRB- gene with delayed_sleep_phase_syndrome .
17877143	0	AA-NAT	76,82	arylalkylamine_N-acetyltransferase	40,74	AA-NAT	arylalkylamine N-acetyltransferase	15	15	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	In vitro effects of steroid hormones on arylalkylamine_N-acetyltransferase -LRB- AA-NAT -RRB- activity in the pineal of fish , Clarias gariepinus -LRB- Burchell , 1822 -RRB- during different phases of breeding cycle .
21341536	0	AA-NAT	104,110	arylalkylamine_N-acetyltransferase	68,102	AA-NAT	arylalkylamine N-acetyltransferase	15	15	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	In vitro effects of 5-hydroxytryptophan , indoleamines and leptin on arylalkylamine_N-acetyltransferase -LRB- AA-NAT -RRB- activity in pineal organ of the fish , Clarias gariepinus -LRB- Burchell , 1822 -RRB- during different phases of the breeding cycle .
22575765	0	AAA	8,11	Bcs1	0,4	AAA	Bcs1	100329167	617	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Bcs1 , a AAA protein of the mitochondria with a role in the biogenesis of the respiratory chain .
10343976	0	AADC	56,60	L-amino_acid_decarboxylase	28,54	AADC	L-amino acid decarboxylase	24311(Tax:10116)	24311(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	L-deprenyl induces aromatic L-amino_acid_decarboxylase -LRB- AADC -RRB- mRNA in the rat substantia nigra and ventral tegmentum .
11148450	0	AADC	59,63	L-amino_acid_decarboxylase	31,57	AADC	L-amino acid decarboxylase	1644	1644	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the aromatic L-amino_acid_decarboxylase -LRB- AADC -RRB- gene and its expression in the attachment and metamorphosis of the barnacle , Balanus amphitrite .
19601813	0	AAG	3,6	HSP90	11,16	AAG	HSP90	4350	3320	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	17 AAG for HSP90 inhibition in cancer -- from bench to bedside .
23564791	0	AAMP	55,59	angio-associated_migratory_cell_protein	14,53	AAMP	angio-associated migratory cell protein	14	14	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	The impact of angio-associated_migratory_cell_protein -LRB- AAMP -RRB- on breast_cancer cells in vitro and its clinical significance .
11985883	0	AANAT	59,64	arylalkylamine_N-acetyltransferase	23,57	AANAT	arylalkylamine N-acetyltransferase	25120(Tax:10116)	25120(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Neuronal expression of arylalkylamine_N-acetyltransferase -LRB- AANAT -RRB- mRNA in the rat brain .
16687311	0	AANAT	50,55	arylalkylamine_N-acetyltransferase	14,48	AANAT	arylalkylamine N-acetyltransferase	15	15	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of arylalkylamine_N-acetyltransferase -LRB- AANAT -RRB- in the retina .
20459461	0	AANAT	77,82	arylalkylamine_N-acetyltransferase	41,75	AANAT	arylalkylamine N-acetyltransferase	15	15	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Resequencing and association analysis of arylalkylamine_N-acetyltransferase -LRB- AANAT -RRB- gene and its contribution to major_depression susceptibility .
17292900	0	AANAT2	49,55	arylalkylamine_N-acetyltransferase	13,47	AANAT2	arylalkylamine N-acetyltransferase	100135881(Tax:8022)	100135881(Tax:8022)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Evidence for arylalkylamine_N-acetyltransferase -LRB- AANAT2 -RRB- expression in rainbow_trout peripheral tissues with emphasis in the gastrointestinal tract .
17245353	0	AAV	13,16	CD8	33,36	AAV	CD8	17	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Pre-existing AAV capsid-specific CD8 + T cells are unable to eliminate AAV-transduced hepatocytes .
9027511	0	ABC	23,26	ABC3	33,37	ABC	ABC3	10058	21	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The cloning of a human ABC gene -LRB- ABC3 -RRB- mapping to chromosome 16p13 .3 .
17686774	0	ABC	111,114	ATP-binding_cassette	89,109	ABC	ATP-binding cassette	10058	10058	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding_cassette -LRB- ABC -RRB- transporter ABCG2 protein .
19067393	0	ABC	40,43	ATP-binding_cassette	18,38	ABC	ATP-binding cassette	10058	10058	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of placental ATP-binding_cassette -LRB- ABC -RRB- transporters in antiretroviral therapy during pregnancy .
22456339	0	ABC	49,52	ATP_binding_cassette	27,47	ABC	ATP binding cassette	10058	10058	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Expression of the 49 human ATP_binding_cassette -LRB- ABC -RRB- genes in pluripotent embryonic stem cells and in early - and late-stage multipotent mesenchymal stem cells : possible role of ABC plasma membrane transporters in maintaining human stem cell pluripotency .
22240895	0	ABC-me	30,36	GATA-1	70,76	ABC-me	GATA-1	56199(Tax:10090)	14460(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	The mitochondrial transporter ABC-me -LRB- ABCB10 -RRB- , a downstream target of GATA-1 , is essential for erythropoiesis in vivo .
10924356	0	ABC1	0,4	LXR	77,80	ABC1	LXR	11303(Tax:10090)	22259(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR .
9027511	0	ABC3	33,37	ABC	23,26	ABC3	ABC	21	10058	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The cloning of a human ABC gene -LRB- ABC3 -RRB- mapping to chromosome 16p13 .3 .
10931828	0	ABC50	0,5	eukaryotic_initiation_factor_2	21,51	ABC50	eukaryotic initiation factor 2	23	8894	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ABC50 interacts with eukaryotic_initiation_factor_2 and associates with the ribosome in an ATP-dependent manner .
11350058	0	ABC8	63,67	ABCG1	56,61	ABC8	ABCG1	9619	9619	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the ATP-binding_cassette_transporter gene ABCG1 -LRB- ABC8 -RRB- in Tangier_disease .
26004638	0	ABCA1	20,25	ATP-Binding_Cassette_Transporter	30,62	ABCA1	ATP-Binding Cassette Transporter	19	24	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Low Serum Levels of ABCA1 , an ATP-Binding_Cassette_Transporter , Are Predictive_of_Preeclampsia .
20303467	0	ABCA1	49,54	ATP-binding-cassette-transporter-A1	12,47	ABCA1	ATP-binding-cassette-transporter-A1	19	19	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The role of ATP-binding-cassette-transporter-A1 -LRB- ABCA1 -RRB- gene polymorphism on coronary_artery_disease risk .
24016265	0	ABCA1	62,67	ATP-binding_cassette_A1	29,52	ABCA1	ATP-binding cassette A1	19	19	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The target of regulating the ATP-binding_cassette_A1 protein -LRB- ABCA1 -RRB- : promoting ABCA1-mediated cholesterol efflux in different cells .
11558901	0	ABCA1	139,144	ATP-binding_cassette_transporter_A1	102,137	ABCA1	ATP-binding cassette transporter A1	19	19	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	High-density single-nucleotide polymorphism -LRB- SNP -RRB- map of the 150-kb region corresponding to the human ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- gene .
12111381	0	ABCA1	122,127	ATP-binding_cassette_transporter_A1	84,119	ABCA1	ATP-binding cassette transporter A1	19	19	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- gene in Japanese patients with Tangier_disease .
22982414	0	ABCA1	83,88	ATP-binding_cassette_transporter_A1	41,76	ABCA1	ATP-binding cassette transporter A1	19	19	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Meta-analysis on association between the ATP-binding_cassette_transporter_A1 gene -LRB- ABCA1 -RRB- and Alzheimer 's _ disease .
20338636	0	ABCA1	68,73	ATP_binding_cassette_transporter_A1	31,66	ABCA1	ATP binding cassette transporter A1	19	19	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of ATP_binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- in first trimester and term human placenta .
17936760	0	ABCA1	34,39	Adiponectin	0,11	ABCA1	Adiponectin	11303(Tax:10090)	9370	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|deficiency deficiency|compound|END_ENTITY	Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver .
25755733	0	ABCA1	24,29	Adiponectin	0,11	ABCA1	Adiponectin	19	9370	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Adiponectin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in RAW 264.7 macrophages .
25281277	0	ABCA1	119,124	ApoA1	132,137	ABCA1	ApoA1	19	335	Gene	Gene	Mutations|compound|START_ENTITY Mutations|compound|END_ENTITY	Treatment of Low HDL-C Subjects with the CETP Modulator Dalcetrapib Increases Plasma Campesterol Only in Those Without ABCA1 and/or ApoA1 Mutations .
25569858	0	ABCA1	50,55	ApoA1	19,24	ABCA1	ApoA1	19	335	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nmod|Interaction	Will Lipidation of ApoA1 through Interaction with ABCA1 at the Intestinal Level Affect the Protective Functions of HDL ?
20844270	0	ABCA1	56,61	Group_X_secretory_phospholipase_A2	0,34	ABCA1	Group X secretory phospholipase A2	11303(Tax:10090)	26565(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Group_X_secretory_phospholipase_A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages .
24729624	0	ABCA1	52,57	HuR	20,23	ABCA1	HuR	19	1994	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNA_binding_protein HuR regulates the expression of ABCA1 .
18789440	0	ABCA1	25,30	IFN-gamma	0,9	ABCA1	IFN-gamma	19	3458	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner .
14668333	0	ABCA1	62,67	Janus_kinase_2	0,14	ABCA1	Janus kinase 2	19	3717	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Janus_kinase_2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol .
16210729	0	ABCA1	113,118	Janus_kinase_2	0,14	ABCA1	Janus kinase 2	19	3717	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Janus_kinase_2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1 .
23564066	0	ABCA1	45,50	LXRa	68,72	ABCA1	LXRa	19	10062	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
25508922	0	ABCA1	1,6	M-CSF	34,39	ABCA1	M-CSF	19	1435	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	-LSB- ABCA1 mRNA and protein levels IN M-CSF macrophages from patients with arterial_stenosis -RSB- .
17991739	0	ABCA1	41,46	OSBP-related_protein_8	0,22	ABCA1	OSBP-related protein 8	19	114882	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	OSBP-related_protein_8 -LRB- ORP8 -RRB- suppresses ABCA1 expression and cholesterol efflux from macrophages .
22503545	0	ABCA1	28,33	PAPP-A	0,6	ABCA1	PAPP-A	19	5069	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PAPP-A negatively regulates ABCA1 , ABCG1 and SR-B1 expression by inhibiting LXRa through the IGF-I-mediated signaling pathway .
27026705	0	ABCA1	30,35	PARP-1	0,6	ABCA1	PARP-1	11303(Tax:10090)	11545(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Represses|dobj|Expression Represses|nsubj|END_ENTITY	PARP-1 Represses LXR-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages .
19304576	0	ABCA1	15,20	Rab8	0,4	ABCA1	Rab8	19	4218	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages .
18484747	0	ABCA1	13,18	SPTLC1	0,6	ABCA1	SPTLC1	19	10558	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter .
20057170	0	ABCA1	37,42	TGF-beta1	0,9	ABCA1	TGF-beta1	19	7040	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	TGF-beta1 up-regulates expression of ABCA1 , ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
18427282	0	ABCA1	22,27	THP-1	65,70	ABCA1	THP-1	19	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|macrophages macrophages|compound|END_ENTITY	Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway .
19070858	0	ABCA1	30,35	THP-1	163,168	ABCA1	THP-1	19	2736	Gene	Gene	phosphorylation|nummod|START_ENTITY reduces|iobj|phosphorylation protein|dep|reduces protein|dep|kinase kinase|dobj|pathway pathway|nmod|cells cells|amod|macrophage-derived macrophage-derived|amod|END_ENTITY	Eicosapentaenoic_acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic_AMP / protein kinase A signaling pathway in THP-1 macrophage-derived foam cells .
20057170	0	ABCA1	37,42	THP-1	112,117	ABCA1	THP-1	19	2736	Gene	Gene	expression|nmod|START_ENTITY liver|nsubj|expression liver|xcomp|signaling signaling|nmod|cells cells|compound|END_ENTITY	TGF-beta1 up-regulates expression of ABCA1 , ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
20625316	0	ABCA1	24,29	THP-1	67,72	ABCA1	THP-1	19	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells .
21560346	0	ABCA1	78,83	THP-1	87,92	ABCA1	THP-1	19	2736	Gene	Gene	expression|nmod|START_ENTITY upgrades|dobj|expression upgrades|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Pravastatin and rosiglitazone combination therapy upgrades the expression of ABCA1 in THP-1 macrophages -RSB- .
22610793	0	ABCA1	46,51	THP-1	72,77	ABCA1	THP-1	19	2736	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|macrophages macrophages|compound|END_ENTITY	S-Allylcysteine , a garlic compound , increases ABCA1 expression in human THP-1 macrophages .
23305686	0	ABCA1	45,50	THP-1	80,85	ABCA1	THP-1	19	2736	Gene	Gene	DNA|compound|START_ENTITY efflux|nmod|DNA methylation|nsubj|efflux methylation|nmod|cells cells|compound|END_ENTITY	Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells .
23564066	0	ABCA1	45,50	THP-1	94,99	ABCA1	THP-1	19	2736	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nmod|LXRa LXRa|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
25223800	0	ABCA1	57,62	THP-1	107,112	ABCA1	THP-1	19	2736	Gene	Gene	expression|compound|START_ENTITY repressing|dobj|expression repressing|nmod|pathway pathway|nmod|macrophages macrophages|compound|END_ENTITY	Urotensin_II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-kB pathway in THP-1 macrophages .
25225013	0	ABCA1	44,49	THP-1	137,142	ABCA1	THP-1	19	2736	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|receptor receptor|nmod|alpha alpha|acl|signaling signaling|nmod|macrophages macrophages|compound|END_ENTITY	Angiotensin - -LRB- 1-7 -RRB- upregulates expression of ABCA1 and ABCG1 through the Mas receptor via the liver X receptor alpha signaling pathway in THP-1 macrophages treated with Angiotensin_II .
25600616	0	ABCA1	36,41	THP-1	104,109	ABCA1	THP-1	19	2736	Gene	Gene	expression|nmod|START_ENTITY Propofol|dobj|expression Propofol|nmod|PPARy/LXRa PPARy/LXRa|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Propofol up-regulates expression of ABCA1 , ABCG1 , and SR-B1 through the PPARy/LXRa signaling pathway in THP-1 macrophage-derived foam cells .
26102194	0	ABCA1	53,58	THP-1	107,112	ABCA1	THP-1	19	2736	Gene	Gene	Expression|compound|START_ENTITY Enhanced|nmod|Expression Enhanced|nmod|Signaling Signaling|nmod|Cells Cells|compound|END_ENTITY	Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRa Signaling in THP-1 Macrophage-Derived Foam Cells .
26261553	0	ABCA1	20,25	THP-1	98,103	ABCA1	THP-1	19	2736	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nmod|LXRa LXRa|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Lipoxin_A4 promotes ABCA1 expression and cholesterol efflux through the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
26729088	0	ABCA1	31,36	THP-1	51,56	ABCA1	THP-1	19	2736	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Macrophages Macrophages|compound|END_ENTITY	Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages .
23261454	0	ABCA1	16,21	TLR2	0,4	ABCA1	TLR2	11303(Tax:10090)	24088(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	TLR2 stimulates ABCA1 expression via PKC - and PLD2 pathway .
20103810	0	ABCA1	20,25	TNF-alpha	0,9	ABCA1	TNF-alpha	19	7124	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2 .
16492740	0	ABCA1	17,22	TNFalpha	0,8	ABCA1	TNFalpha	19	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells .
11279031	0	ABCA1	108,113	ZNF202	29,35	ABCA1	ZNF202	19	7753	Gene	Gene	ATP_binding_cassette_transporter_A1|appos|START_ENTITY repressor|nmod|ATP_binding_cassette_transporter_A1 repressor|nsubj|zinc_finger_protein_202 zinc_finger_protein_202|appos|END_ENTITY	The zinc_finger_protein_202 -LRB- ZNF202 -RRB- is a transcriptional repressor of ATP_binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- and ABCG1 gene expression and a modulator of cellular lipid efflux .
12611910	0	ABCA1	52,57	ZNF202	0,6	ABCA1	ZNF202	19	7753	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	ZNF202 is inversely regulated with its target genes ABCA1 and apoE during macrophage differentiation and foam cell formation .
22389325	0	ABCA1	76,81	apolipoprotein_A-I	100,118	ABCA1	apolipoprotein A-I	19	335	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein_A-I in HepG2 cells .
20643408	0	ABCA1	99,104	prolactin_regulatory_element-binding	23,59	ABCA1	prolactin regulatory element-binding	313210(Tax:10116)	58842(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Transcriptional factor prolactin_regulatory_element-binding protein-mediated gene transcription of ABCA1 via 3 ' ,5 ' - cyclic_adenosine-5 ' - monophosphate .
25852127	0	ABCA1	27,32	scavenger_receptor-B1	52,73	ABCA1	scavenger receptor-B1	19	949	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Lipoprotein -LRB- a -RRB- upregulates ABCA1 in liver cells via scavenger_receptor-B1 through its oxidised phospholipids .
11940594	0	ABCA3	126,131	LBM180	18,24	ABCA3	LBM180	21	21	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of LBM180 , a lamellar body limiting membrane protein of alveolar_type_II cells , as the ABC transporter protein ABCA3 .
18096869	0	ABCA3	16,21	STAT3	0,5	ABCA3	STAT3	27410(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells .
10958761	0	ABCA4	17,22	ABCR	24,28	ABCA4	ABCR	24	24	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the ABCA4 -LRB- ABCR -RRB- gene are the major cause of autosomal_recessive_cone-rod_dystrophy .
10958763	0	ABCA4	52,57	ABCR	59,63	ABCA4	ABCR	24	24	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A comprehensive survey of sequence variation in the ABCA4 -LRB- ABCR -RRB- gene in Stargardt_disease and age-related_macular_degeneration .
11384574	0	ABCA4	22,27	ABCR	16,20	ABCA4	ABCR	24	24	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of the ABCR -LRB- ABCA4 -RRB- gene in 4-aminoquinoline retinopathy : is retinal_toxicity by chloroquine and hydroxychloroquine related to Stargardt_disease ?
11385708	0	ABCA4	12,17	ABCR	19,23	ABCA4	ABCR	24	24	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Spectrum of ABCA4 -LRB- ABCR -RRB- gene mutations in Spanish patients with autosomal_recessive_macular_dystrophies .
11726554	0	ABCA4	54,59	ABCR	48,52	ABCA4	ABCR	24	24	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Cosegregation and functional analysis of mutant ABCR -LRB- ABCA4 -RRB- alleles in families that manifest both Stargardt_disease and age-related_macular_degeneration .
11846518	0	ABCA4	91,96	ABCR	97,101	ABCA4	ABCR	24	24	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Visual function in patients with cone-rod_dystrophy -LRB- CRD -RRB- associated with mutations in the ABCA4 -LRB- ABCR -RRB- gene .
12037008	0	ABCA4	91,96	ABCR	98,102	ABCA4	ABCR	24	24	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Phenotypic spectrum of autosomal_recessive_cone-rod_dystrophies caused by mutations in the ABCA4 -LRB- ABCR -RRB- gene .
14517951	0	ABCA4	48,53	ABCR	42,46	ABCA4	ABCR	24	24	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotyping microarray -LRB- gene chip -RRB- for the ABCR -LRB- ABCA4 -RRB- gene .
15017103	0	ABCA4	53,58	ABCR	60,64	ABCA4	ABCR	24	24	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of a homozygous nonsense mutation in the ABCA4 -LRB- ABCR -RRB- gene with cone-rod_dystrophy phenotype in an Italian family .
15494742	0	ABCA4	42,47	ABCR	49,53	ABCA4	ABCR	24	24	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Microarray-based mutation analysis of the ABCA4 -LRB- ABCR -RRB- gene in autosomal recessive cone-rod_dystrophy and retinitis_pigmentosa .
18827354	0	ABCA5	107,112	P-glycoprotein	51,65	ABCA5	P-glycoprotein	23461	5243	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 -LRB- ABCA5 -RRB- proteins in hematoencephalic barrier cells .
21918980	0	ABCB1	46,51	ABCC2	53,58	ABCB1	ABCC2	5243	1244	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	A comprehensive study of polymorphisms in the ABCB1 , ABCC2 , ABCG2 , NR1I2 genes and lymphoma risk .
21918980	0	ABCB1	46,51	ABCG2	60,65	ABCB1	ABCG2	5243	9429	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	A comprehensive study of polymorphisms in the ABCB1 , ABCC2 , ABCG2 , NR1I2 genes and lymphoma risk .
15167702	0	ABCB1	31,36	CYP3A5	14,20	ABCB1	CYP3A5	5243	1577	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients .
15502717	0	ABCB1	30,35	CYP3A5	13,19	ABCB1	CYP3A5	5243	1577	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients .
15919447	0	ABCB1	26,31	CYP3A5	10,16	ABCB1	CYP3A5	5243	1577	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients .
21094796	0	ABCB1	29,34	CYP3A5	13,19	ABCB1	CYP3A5	5243	1577	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on the pharmacokinetics of tacrolimus in Chinese_renal_transplant_recipients .
24888374	0	ABCB1	121,126	EGFR	0,4	ABCB1	EGFR	5243	1956	Gene	Gene	expression|nmod|START_ENTITY mediates|nmod|expression mediates|nsubj|END_ENTITY	EGFR mediates docetaxel resistance in human castration-resistant_prostate_cancer through the Akt-dependent expression of ABCB1 -LRB- MDR1 -RRB- .
25597754	0	ABCB1	91,96	FLT3	4,8	ABCB1	FLT3	5243	2322	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations .
25089713	0	ABCB1	0,5	LRPPRC	25,31	ABCB1	LRPPRC	5243	10128	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC -100 box in its promoter .
12112526	0	ABCB1	66,71	MDR1	60,64	ABCB1	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Preferential expression of a mutant allele of the amplified MDR1 -LRB- ABCB1 -RRB- gene in drug-resistant variants of a human sarcoma .
12352921	0	ABCB1	106,111	MDR1	113,117	ABCB1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Neurotoxicity induced by tacrolimus after liver transplantation : relation to genetic polymorphisms of the ABCB1 -LRB- MDR1 -RRB- gene .
12893986	0	ABCB1	56,61	MDR1	63,67	ABCB1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence diversity and haplotype structure in the human ABCB1 -LRB- MDR1 , multidrug_resistance_transporter -RRB- gene .
15228162	0	ABCB1	30,35	MDR1	24,28	ABCB1	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical aspects of the MDR1 -LRB- ABCB1 -RRB- gene polymorphism .
15280437	0	ABCB1	96,101	MDR1	90,94	ABCB1	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 -LRB- ABCB1 -RRB- gene .
15692830	0	ABCB1	35,40	MDR1	42,46	ABCB1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms of ABCB1 -LRB- MDR1 -RRB- gene and distinct haplotype profile in a West Black African population .
16431292	0	ABCB1	10,15	MDR1	17,21	ABCB1	MDR1	5243	5243	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of ABCB1 -LRB- MDR1 -RRB- haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 * 3 / * 3 non-expressors .
16797284	0	ABCB1	20,25	MDR1	14,18	ABCB1	MDR1	5243	5243	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of MDR1 -LRB- ABCB1 -RRB- polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients .
16869811	0	ABCB1	10,15	MDR1	17,21	ABCB1	MDR1	5243	5243	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of ABCB1 -LRB- MDR1 -RRB- haplotypes derived from G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjects .
17038891	0	ABCB1	24,29	MDR1	31,35	ABCB1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No influence of 3435C > T ABCB1 -LRB- MDR1 -RRB- gene polymorphism on risk of adult_acute_myeloid_leukemia and P-glycoprotein expression in blast cells .
17085864	0	ABCB1	6,11	MDR1	0,4	ABCB1	MDR1	5243	5243	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	MDR1 -LRB- ABCB1 -RRB- gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell_chronic_lymphocytic_leukemia .
17225463	0	ABCB1	79,84	MDR1	86,90	ABCB1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analyses of single nucleotide polymorphisms and haplotype linkage of the human ABCB1 -LRB- MDR1 -RRB- gene in Korean .
17377214	0	ABCB1	10,15	MDR1	17,21	ABCB1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Impact of ABCB1 -LRB- MDR1 -RRB- gene polymorphism and P-glycoprotein inhibitors on digoxin serum concentration in congestive heart_failure patients .
17913323	0	ABCB1	0,5	MDR1	7,11	ABCB1	MDR1	5243	5243	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	ABCB1 -LRB- MDR1 -RRB- gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive_disorder .
18003028	0	ABCB1	54,59	MDR1	49,53	ABCB1	MDR1	5243	5243	Gene	Gene	GENE|appos|START_ENTITY GENE|compound|END_ENTITY	MDRView : a visualization of the polymorphisms of MDR1 -LRB- ABCB1 -RRB- GENE in breast_cancer .
18436433	0	ABCB1	121,126	MDR1	128,132	ABCB1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 -LRB- MDR1 -RRB- gene .
19005421	0	ABCB1	50,55	MDR1	44,48	ABCB1	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations between common variants in the MDR1 -LRB- ABCB1 -RRB- gene and ulcerative_colitis among North Indians .
19714749	0	ABCB1	30,35	MDR1	24,28	ABCB1	MDR1	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High gene expression of MDR1 -LRB- ABCB1 -RRB- is associated with medical treatment response and long-term remission in patients with ulcerative_colitis .
20520719	0	ABCB1	14,19	MDR1	21,25	ABCB1	MDR1	5243	5243	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Inhibition of ABCB1 -LRB- MDR1 -RRB- expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma .
21851199	0	ABCB1	20,25	MDR1	27,31	ABCB1	MDR1	5243	5243	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between ABCB1 -LRB- MDR1 -RRB- gene 3435_C > T polymorphism and colchicine unresponsiveness of FMF patients .
21987299	0	ABCB1	37,42	MDR1	44,48	ABCB1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations between variants in the ABCB1 -LRB- MDR1 -RRB- gene and corticosteroid dependence in children with Crohn 's _ disease .
23930592	0	ABCB1	54,59	MDR1	48,52	ABCB1	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genotype variability and haplotype frequency of MDR1 -LRB- ABCB1 -RRB- gene polymorphism in Morocco .
24413370	0	ABCB1	93,98	MDR1	87,91	ABCB1	MDR1	5243	5243	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Hepatopathy-Thrombocytopenia_Syndrome During Actinomycin_D Treatment May Be Related to MDR1 -LRB- ABCB1 -RRB- Gene Polymorphisms .
25725700	0	ABCB1	46,51	MDR1	53,57	ABCB1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genotype variability and haplotype profile of ABCB1 -LRB- MDR1 -RRB- gene polymorphisms in macedonian population .
26194248	0	ABCB1	38,43	Mdr1b	32,37	ABCB1	Mdr1b	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	Genes|compound|START_ENTITY Genes|compound|END_ENTITY	Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice .
26006083	0	ABCB1	30,35	NEDD4-1	76,83	ABCB1	NEDD4-1	5243	4734	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1 .
26006083	0	ABCB1	30,35	NEDD4-1	76,83	ABCB1	NEDD4-1	5243	4734	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1 .
21918980	0	ABCB1	46,51	NR1I2	67,72	ABCB1	NR1I2	5243	8856	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	A comprehensive study of polymorphisms in the ABCB1 , ABCC2 , ABCG2 , NR1I2 genes and lymphoma risk .
15637529	0	ABCB1	104,109	P-glycoprotein	111,125	ABCB1	P-glycoprotein	5243	5243	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Hepatic technetium_Tc 99m-labeled sestamibi elimination rate and ABCB1 -LRB- MDR1 -RRB- genotype as indicators of ABCB1 -LRB- P-glycoprotein -RRB- activity in patients with cancer .
17933684	0	ABCB1	76,81	P-glycoprotein	60,74	ABCB1	P-glycoprotein	18669(Tax:10090)	67078(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Drug-drug interactions affected by the transporter protein , P-glycoprotein -LRB- ABCB1 , MDR1 -RRB- I. Preclinical aspects .
19846941	0	ABCB1	89,94	P-glycoprotein	73,87	ABCB1	P-glycoprotein	18669(Tax:10090)	5243	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|triterpenoids triterpenoids|nmod|balsamina balsamina|nmod|END_ENTITY	Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein -LRB- ABCB1 -RRB- by flow cytometry and real-time fluorometry .
21341745	0	ABCB1	48,53	P-glycoprotein	32,46	ABCB1	P-glycoprotein	5243	5243	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	A novel approach for predicting P-glycoprotein -LRB- ABCB1 -RRB- inhibition using molecular interaction fields .
21366702	0	ABCB1	16,21	P-glycoprotein	0,14	ABCB1	P-glycoprotein	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	P-glycoprotein -LRB- ABCB1 -RRB- expression in human skin is mainly restricted to dermal components .
21999196	0	ABCB1	13,18	P-glycoprotein	20,34	ABCB1	P-glycoprotein	5243	5243	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of ABCB1 -LRB- P-glycoprotein -RRB- haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural_hypotension in healthy volunteers .
25036383	0	ABCB1	61,66	P-glycoprotein	45,59	ABCB1	P-glycoprotein	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interrogation of multidrug resistance -LRB- MDR1 -RRB- P-glycoprotein -LRB- ABCB1 -RRB- expression in human pancreatic_carcinoma cells : correlation of 99mTc-Sestamibi uptake with western blot analysis .
25401518	0	ABCB1	16,21	Wnt5A	0,5	ABCB1	Wnt5A	5243	7474	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/b-catenin pathway .
21133723	0	ABCB1	76,81	adenosine_triphosphate-binding_cassette_subfamily_B_member_1	14,74	ABCB1	adenosine triphosphate-binding cassette subfamily B member 1	5243	5243	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Assessment of adenosine_triphosphate-binding_cassette_subfamily_B_member_1 -LRB- ABCB1 -RRB- mRNA expression in patients with de novo chronic_myelogenous_leukemia : the role of different cell types .
17354009	0	ABCB1	20,25	p-glycoprotein	27,41	ABCB1	p-glycoprotein	5243	5243	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	Potential impact of ABCB1 -LRB- p-glycoprotein -RRB- polymorphisms on avermectin toxicity in humans .
21666806	0	ABCB19	20,26	phot1	0,5	ABCB19	phot1	822519(Tax:3702)	823721(Tax:3702)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	phot1 inhibition of ABCB19 primes lateral auxin fluxes in the shoot apex required for phototropism .
19273348	0	ABCB4	32,37	MDR3	26,30	ABCB4	MDR3	5244	5244	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Liver_diseases related to MDR3 -LRB- ABCB4 -RRB- gene deficiency .
19674157	0	ABCB4	86,91	Receptor_for_activated_C-kinase_1	0,33	ABCB4	Receptor for activated C-kinase 1	5244	10399	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Receptor_for_activated_C-kinase_1 regulates the cellular localization and function of ABCB4 .
15203080	0	ABCB4	73,78	multidrug_resistance_P-glycoprotein_3	34,71	ABCB4	multidrug resistance P-glycoprotein 3	5244	5244	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations identified in the human multidrug_resistance_P-glycoprotein_3 -LRB- ABCB4 -RRB- gene in patients with primary hepatolithiasis .
24525737	0	ABCB5	66,71	PML	48,51	ABCB5	PML	77706(Tax:10090)	18854(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	The helicase HAGE prevents interferon-a-induced PML expression in ABCB5 + malignant_melanoma-initiating cells by promoting the expression of SOCS1 .
22761424	0	ABCB6	115,120	aryl_hydrocarbon_receptor	134,159	ABCB6	aryl hydrocarbon receptor	74104(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Polycyclic_aromatic_hydrocarbons -LRB- PAHs -RRB- mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl_hydrocarbon_receptor -LRB- AhR -RRB- .
15760339	0	ABCB_5	117,123	ABCB_5alpha	43,54	ABCB 5	ABCB 5alpha	340273	340273	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Principal expression of two mRNA isoforms -LRB- ABCB_5alpha and ABCB_5beta -RRB- of the ATP-binding_cassette_transporter gene ABCB_5 in melanoma cells and melanocytes .
15760339	0	ABCB_5alpha	43,54	ABCB_5	117,123	ABCB 5alpha	ABCB 5	340273	340273	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Principal expression of two mRNA isoforms -LRB- ABCB_5alpha and ABCB_5beta -RRB- of the ATP-binding_cassette_transporter gene ABCB_5 in melanoma cells and melanocytes .
11139250	0	ABCC1	59,64	MRP1	53,57	ABCC1	MRP1	4363	4363	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Identification of novel polymorphisms in the pM5 and MRP1 -LRB- ABCC1 -RRB- genes at locus 16p13 .1 and exclusion of both genes as responsible for pseudoxanthoma_elasticum .
21177244	0	ABCC1	39,44	MRP1	33,37	ABCC1	MRP1	4363	4363	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of human MRP1 -LRB- ABCC1 -RRB- is dependent on amino_acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2 .
16621983	0	ABCC1	56,61	multidrug_resistance_protein_1	24,54	ABCC1	multidrug resistance protein 1	17250(Tax:10090)	18669(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dendritic_cells require multidrug_resistance_protein_1 -LRB- ABCC1 -RRB- transporter activity for differentiation .
21918980	0	ABCC2	53,58	ABCB1	46,51	ABCC2	ABCB1	1244	5243	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	A comprehensive study of polymorphisms in the ABCB1 , ABCC2 , ABCG2 , NR1I2 genes and lymphoma risk .
26189305	0	ABCC2	7,12	GABRA1	28,34	ABCC2	GABRA1	1244	2554	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
16863439	0	ABCC2	36,41	MRP2	30,34	ABCC2	MRP2	1244	1244	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Structure and function of the MRP2 -LRB- ABCC2 -RRB- protein and its role in drug disposition .
18926681	0	ABCC2	23,28	MRP2	17,21	ABCC2	MRP2	1244	1244	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms of MRP2 -LRB- ABCC2 -RRB- are associated with susceptibility to nonalcoholic_fatty_liver_disease .
23135210	0	ABCC2	6,11	MRP2	0,4	ABCC2	MRP2	1244	1244	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MRP2 -LRB- ABCC2 , cMOAT -RRB- expression in nuclear envelope of primary fallopian_tube_cancer cells is a new unfavorable prognostic factor .
16426233	0	ABCC2	44,49	Mrp2	38,42	ABCC2	Mrp2	12780(Tax:10090)	12780(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of Nrf2 in the regulation of the Mrp2 -LRB- ABCC2 -RRB- gene .
19857663	0	ABCC2	48,53	Multidrug_resistance-associated_protein_2	0,41	ABCC2	Multidrug resistance-associated protein 2	1244	1244	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multidrug_resistance-associated_protein_2 gene -LRB- ABCC2 -RRB- variant in kidney allograft recipients .
26189305	0	ABCC2	7,12	SCN1A	14,19	ABCC2	SCN1A	1244	6323	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
26189305	0	ABCC2	7,12	SCN2A	21,26	ABCC2	SCN2A	1244	6326	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
17997497	0	ABCC2	65,70	multidrug-resistance-associated_protein	19,58	ABCC2	multidrug-resistance-associated protein	1244	8714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the multidrug-resistance-associated_protein gene -LRB- ABCC2 -RRB- variants with intrahepatic_cholestasis_of_pregnancy .
11706036	0	ABCC2	57,62	multidrug_resistance-associated_protein_2	14,55	ABCC2	multidrug resistance-associated protein 2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of multidrug_resistance-associated_protein_2 -LRB- ABCC2 -RRB- by the nuclear receptors pregnane_X_receptor , farnesoid_X-activated_receptor , and constitutive_androstane_receptor .
17047488	0	ABCC2	39,44	multidrug_resistance-associated_protein_2	58,99	ABCC2	multidrug resistance-associated protein 2	1244	1244	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|expression expression|amod|END_ENTITY	Association of genetic polymorphism in ABCC2 with hepatic multidrug_resistance-associated_protein_2 expression and pravastatin pharmacokinetics .
11706036	0	ABCC2	57,62	pregnane_X_receptor	89,108	ABCC2	pregnane X receptor	25303(Tax:10116)	84385(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of multidrug_resistance-associated_protein_2 -LRB- ABCC2 -RRB- by the nuclear receptors pregnane_X_receptor , farnesoid_X-activated_receptor , and constitutive_androstane_receptor .
14570758	0	ABCC3	13,18	MRP3	20,24	ABCC3	MRP3	76408(Tax:10090)	76408(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of ABCC3 -LRB- MRP3 -RRB- by pregnane_X_receptor activators .
22585709	0	ABCC3	40,45	MRP3	47,51	ABCC3	MRP3	8714	8714	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Amplification and overexpression of the ABCC3 -LRB- MRP3 -RRB- gene in primary breast_cancer .
17344354	0	ABCC4	21,26	MRP4	15,19	ABCC4	MRP4	239273(Tax:10090)	239273(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of MRP4 -LRB- ABCC4 -RRB- in the luminal efflux of ceftizoxime and cefazolin in the kidney .
15645653	0	ABCC6	78,83	MRP6	85,89	ABCC6	MRP6	368	368	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of two novel missense mutations -LRB- p.R1221C and p.R1357W -RRB- in the ABCC6 -LRB- MRP6 -RRB- gene in a Japanese patient with pseudoxanthoma_elasticum -LRB- PXE -RRB- .
15889270	0	ABCC6	12,17	MRP6	19,23	ABCC6	MRP6	368	368	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of ABCC6 -LRB- MRP6 -RRB- in normal human tissues .
23902843	0	ABCC8	1,6	KCNJ11	8,14	ABCC8	KCNJ11	6833	3767	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- ABCC8 , KCNJ11 and GLUD1 gene mutation analysis in congenital_hyperinsulinism pedigree -RSB- .
21992908	0	ABCC8	50,55	SUR1	57,61	ABCC8	SUR1	6833	6833	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Congenital_hyperinsulinism caused by mutations in ABCC8 -LRB- SUR1 -RRB- gene .
17686565	0	ABCD2	75,80	PPARalpha	99,108	ABCD2	PPARalpha	225	5465	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene -LRB- ABCD2 -RRB- independently of PPARalpha in rodents .
18834645	0	ABCD2	95,100	TRalpha	56,63	ABCD2	TRalpha	26874(Tax:10090)	14685(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY roles|nmod|expression roles|nmod|END_ENTITY	Distinct modulatory roles for thyroid hormone receptors TRalpha and TRbeta in SREBP1-activated ABCD2 expression .
23437103	0	ABCD2	0,5	b-catenin	28,37	ABCD2	b-catenin	225	1499	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	ABCD2 is a direct target of b-catenin and TCF-4 : implications for X-linked_adrenoleukodystrophy therapy .
16275648	0	ABCE1	96,101	gag	87,90	ABCE1	gag	6059	155030(Tax:11676)	Gene	Gene	required|nmod|START_ENTITY required|nmod|interaction interaction|nmod|END_ENTITY	Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 -LRB- HP68 -RRB- , a cellular protein important for HIV-1 capsid assembly .
11350058	0	ABCG1	56,61	ABC8	63,67	ABCG1	ABC8	9619	9619	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the ATP-binding_cassette_transporter gene ABCG1 -LRB- ABC8 -RRB- in Tangier_disease .
23770099	0	ABCG1	64,69	ATPase	22,28	ABCG1	ATPase	9619	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1 .
22984960	0	ABCG1	22,27	SR-BI	0,5	ABCG1	SR-BI	100759619	100736552	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3 .
17293612	0	ABCG1	28,33	beta-amyloid_precursor_protein	103,133	ABCG1	beta-amyloid precursor protein	9619	351	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|distribution distribution|nmod|END_ENTITY	The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid_precursor_protein .
21918980	0	ABCG2	60,65	ABCB1	46,51	ABCG2	ABCB1	9429	5243	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	A comprehensive study of polymorphisms in the ABCB1 , ABCC2 , ABCG2 , NR1I2 genes and lymphoma risk .
17686774	0	ABCG2	128,133	ATP-binding_cassette	89,109	ABCG2	ATP-binding cassette	9429	10058	Gene	Gene	protein|nummod|START_ENTITY protein|amod|END_ENTITY	Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding_cassette -LRB- ABC -RRB- transporter ABCG2 protein .
22778153	0	ABCG2	124,129	BCR-ABL	10,17	ABCG2	BCR-ABL	9429	25	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2 .
12694888	0	ABCG2	63,68	BCRP	70,74	ABCG2	BCRP	9429	9429	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic variation in the ATP-binding_cassette_transporter gene ABCG2 -LRB- BCRP -RRB- in a Swedish population .
15475413	0	ABCG2	25,30	BCRP	32,36	ABCG2	BCRP	9429	9429	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional assessment of ABCG2 -LRB- BCRP -RRB- gene polymorphisms to protein expression in human placenta .
15955871	0	ABCG2	21,26	BCRP	15,19	ABCG2	BCRP	9429	9429	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of BCRP -LRB- ABCG2 -RRB- in the biliary excretion of pitavastatin .
18623116	0	ABCG2	33,38	BCRP	27,31	ABCG2	BCRP	9429	9429	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Folate deprivation induces BCRP -LRB- ABCG2 -RRB- expression and mitoxantrone resistance in Caco-2 cells .
20682644	0	ABCG2	14,19	BCRP	21,25	ABCG2	BCRP	9429	9429	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ABCG2 -LRB- BCRP -RRB- is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype .
22354538	0	ABCG2	37,42	BCRP	76,80	ABCG2	BCRP	478472(Tax:9615)	478472(Tax:9615)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway .
25028581	0	ABCG2	14,19	BCRP	21,25	ABCG2	BCRP	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ABCG2 -LRB- BCRP -RRB- in mouse models with enhanced erythropoiesis .
23290300	0	ABCG2	102,107	CD133	95,100	ABCG2	CD133	312382(Tax:10116)	60357(Tax:10116)	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133 + ABCG2 + CXCR4 + mesenchymal stem cells : development of autologous cell-based therapeutics for traumatic_brain_injury .
23438193	0	ABCG2	33,38	CD133	80,85	ABCG2	CD133	9429	8842	Gene	Gene	START_ENTITY|nmod|resistance resistance|nmod|END_ENTITY	Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90 -LRB- + -RRB- CD133 -LRB- + -RRB- liver_cancer stem cells .
23622764	0	ABCG2	68,73	CD147	0,5	ABCG2	CD147	9429	682	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|nsubj|END_ENTITY	CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function .
23290300	0	ABCG2	102,107	CXCR4	108,113	ABCG2	CXCR4	312382(Tax:10116)	60628(Tax:10116)	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133 + ABCG2 + CXCR4 + mesenchymal stem cells : development of autologous cell-based therapeutics for traumatic_brain_injury .
22452996	0	ABCG2	47,52	Hypoxia-inducible_factor-2a	0,27	ABCG2	Hypoxia-inducible factor-2a	9429	2034	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	Hypoxia-inducible_factor-2a is associated with ABCG2 expression , histology-grade and Ki67 expression in breast_invasive_ductal_carcinoma .
20682644	0	ABCG2	14,19	Nrf2	43,47	ABCG2	Nrf2	9429	4780	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of ABCG2 -LRB- BCRP -RRB- is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype .
15845415	0	ABCG2	77,82	P-glycoprotein	39,53	ABCG2	P-glycoprotein	9429	5243	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Multidrug resistance proteins : role of P-glycoprotein , MRP1 , MRP2 , and BCRP -LRB- ABCG2 -RRB- in tissue defense .
22123128	0	ABCG2	125,130	P-glycoprotein	52,66	ABCG2	P-glycoprotein	9429	5243	Gene	Gene	BCRP|dep|START_ENTITY END_ENTITY|appos|BCRP	Functional significance of genetic polymorphisms in P-glycoprotein -LRB- MDR1 , ABCB1 -RRB- and breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- .
26583330	0	ABCG2	111,116	SOX4	0,4	ABCG2	SOX4	9429	6659	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	SOX4 contributes to the progression of cervical_cancer and the resistance to the chemotherapeutic drug through ABCG2 .
14973083	0	ABCG2	93,98	breast_cancer_resistance_protein	59,91	ABCG2	breast cancer resistance protein	9429	9429	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel estrogen response element in the breast_cancer_resistance_protein -LRB- ABCG2 -RRB- gene .
16146333	0	ABCG2	46,51	breast_cancer_resistance_protein	12,44	ABCG2	breast cancer resistance protein	9429	9429	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the breast_cancer_resistance_protein -LRB- ABCG2 -RRB- in drug transport .
19170519	0	ABCG2	69,74	breast_cancer_resistance_protein	35,67	ABCG2	breast cancer resistance protein	9429	9429	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|nmod|END_ENTITY	Potent and selective inhibitors of breast_cancer_resistance_protein -LRB- ABCG2 -RRB- derived from the p-glycoprotein -LRB- ABCB1 -RRB- modulator tariquidar .
19572416	0	ABCG2	103,108	breast_cancer_resistance_protein	63,95	ABCG2	breast cancer resistance protein	9429	9429	Gene	Gene	BCRP|dep|START_ENTITY END_ENTITY|appos|BCRP	A fluorescence-based in vitro assay for drug interactions with breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- .
20854129	0	ABCG2	67,72	breast_cancer_resistance_protein	27,59	ABCG2	breast cancer resistance protein	9429	9429	Gene	Gene	BCRP|dep|START_ENTITY END_ENTITY|appos|BCRP	Fetoprotective activity of breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- : expression and function throughout pregnancy .
20952483	0	ABCG2	50,55	breast_cancer_resistance_protein	16,48	ABCG2	breast cancer resistance protein	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the breast_cancer_resistance_protein -LRB- ABCG2 -RRB- in the distribution of sorafenib to the brain .
23539627	0	ABCG2	109,114	breast_cancer_resistance_protein	75,107	ABCG2	breast cancer resistance protein	9429	9429	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	IMP3 protein promotes chemoresistance in breast_cancer cells by regulating breast_cancer_resistance_protein -LRB- ABCG2 -RRB- expression .
19170519	0	ABCG2	69,74	p-glycoprotein	93,107	ABCG2	p-glycoprotein	9429	5243	Gene	Gene	inhibitors|appos|START_ENTITY derived|nsubj|inhibitors derived|nmod|tariquidar tariquidar|amod|END_ENTITY	Potent and selective inhibitors of breast_cancer_resistance_protein -LRB- ABCG2 -RRB- derived from the p-glycoprotein -LRB- ABCB1 -RRB- modulator tariquidar .
18038765	0	ABCG4	89,94	Abcg4	146,151	ABCG4	Abcg4	64137	192663(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4 : site-specific expression of mouse Abcg4 in brain .
12777468	0	ABCG5	25,30	LXR	125,128	ABCG5	LXR	27409(Tax:10090)	22259(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages : differential role of LXR .
10958761	0	ABCR	24,28	ABCA4	17,22	ABCR	ABCA4	24	24	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the ABCA4 -LRB- ABCR -RRB- gene are the major cause of autosomal_recessive_cone-rod_dystrophy .
10958763	0	ABCR	59,63	ABCA4	52,57	ABCR	ABCA4	24	24	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A comprehensive survey of sequence variation in the ABCA4 -LRB- ABCR -RRB- gene in Stargardt_disease and age-related_macular_degeneration .
11384574	0	ABCR	16,20	ABCA4	22,27	ABCR	ABCA4	24	24	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of the ABCR -LRB- ABCA4 -RRB- gene in 4-aminoquinoline retinopathy : is retinal_toxicity by chloroquine and hydroxychloroquine related to Stargardt_disease ?
11385708	0	ABCR	19,23	ABCA4	12,17	ABCR	ABCA4	24	24	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Spectrum of ABCA4 -LRB- ABCR -RRB- gene mutations in Spanish patients with autosomal_recessive_macular_dystrophies .
11726554	0	ABCR	48,52	ABCA4	54,59	ABCR	ABCA4	24	24	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Cosegregation and functional analysis of mutant ABCR -LRB- ABCA4 -RRB- alleles in families that manifest both Stargardt_disease and age-related_macular_degeneration .
11846518	0	ABCR	97,101	ABCA4	91,96	ABCR	ABCA4	24	24	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Visual function in patients with cone-rod_dystrophy -LRB- CRD -RRB- associated with mutations in the ABCA4 -LRB- ABCR -RRB- gene .
12037008	0	ABCR	98,102	ABCA4	91,96	ABCR	ABCA4	24	24	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Phenotypic spectrum of autosomal_recessive_cone-rod_dystrophies caused by mutations in the ABCA4 -LRB- ABCR -RRB- gene .
14517951	0	ABCR	42,46	ABCA4	48,53	ABCR	ABCA4	24	24	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotyping microarray -LRB- gene chip -RRB- for the ABCR -LRB- ABCA4 -RRB- gene .
15017103	0	ABCR	60,64	ABCA4	53,58	ABCR	ABCA4	24	24	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of a homozygous nonsense mutation in the ABCA4 -LRB- ABCR -RRB- gene with cone-rod_dystrophy phenotype in an Italian family .
15494742	0	ABCR	49,53	ABCA4	42,47	ABCR	ABCA4	24	24	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Microarray-based mutation analysis of the ABCA4 -LRB- ABCR -RRB- gene in autosomal recessive cone-rod_dystrophy and retinitis_pigmentosa .
19178697	0	ABC_transporter	57,72	ABC_transporter	97,112	ABC transporter	ABC transporter	13877144	13877144	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	Export of recombinant proteins in Escherichia_coli using ABC_transporter with an attached lipase ABC_transporter recognition domain -LRB- LARD -RRB- .
19178697	0	ABC_transporter	97,112	ABC_transporter	57,72	ABC transporter	ABC transporter	13877144	13877144	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Export of recombinant proteins in Escherichia_coli using ABC_transporter with an attached lipase ABC_transporter recognition domain -LRB- LARD -RRB- .
9345306	0	ABC_transporter	106,121	ALDRP	84,89	ABC transporter	ALDRP	9429	225	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	cDNA cloning and mRNA expression of the human adrenoleukodystrophy_related protein -LRB- ALDRP -RRB- , a peroxisomal ABC_transporter .
21696844	0	ABC_transporter	35,50	AtABCG26	22,30	ABC transporter	AtABCG26	818031(Tax:3702)	820512(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Arabidopsis mutant of AtABCG26 , an ABC_transporter gene , is defective in pollen maturation .
9621516	0	ABC_transporter	43,58	hABC7	65,70	ABC transporter	hABC7	9429	22	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and chromosomal mapping of a novel ABC_transporter gene -LRB- hABC7 -RRB- , a candidate for X-linked_sideroblastic_anemia with spinocerebellar_ataxia .
20395451	0	ABF2	22,26	DREB2C	0,6	ABF2	DREB2C	841095(Tax:3702)	818627(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DREB2C interacts with ABF2 , a bZIP protein regulating abscisic_acid-responsive gene expression , and its overexpression affects abscisic_acid sensitivity .
21085673	0	ABF3	87,91	OST1	37,41	ABF3	OST1	829547(Tax:3702)	829541(Tax:3702)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover .
16299177	0	ABF4	68,72	AtCPK32	45,52	ABF4	AtCPK32	821463(Tax:3702)	824920(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arabidopsis calcium-dependent protein kinase AtCPK32 interacts with ABF4 , a transcriptional regulator of abscisic_acid-responsive gene expression , and modulates its activity .
8609422	0	ABH	172,175	myelin_oligodendrocyte_glycoprotein	72,107	ABH	myelin oligodendrocyte glycoprotein	211064(Tax:10090)	17441(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Encephalitogenic epitopes of myelin_basic_protein , proteolipid_protein , myelin_oligodendrocyte_glycoprotein for experimental_allergic_encephalomyelitis induction in Biozzi ABH -LRB- H-2Ag7 -RRB- mice share an amino_acid motif .
26574024	0	ABHD5	49,54	abhydrolase_domain_containing_5	11,42	ABHD5	abhydrolase domain containing 5	420673(Tax:9031)	420673(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of abhydrolase_domain_containing_5 gene -LRB- ABHD5 -RRB- expression and variations on chicken fat metabolism .
9694699	0	ABI-1	0,5	Abl-interactor_1	32,48	ABI-1	Abl-interactor 1	10006	11308(Tax:10090)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	ABI-1 , a human homolog to mouse Abl-interactor_1 , fuses the MLL gene in acute_myeloid_leukemia with t -LRB- 10 ; 11 -RRB- -LRB- p11 .2 ; q23 -RRB- .
23209429	0	ABI-1	22,27	MIG-10	0,6	ABI-1	MIG-10	10006	5230	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways .
12065416	0	ABI1	65,69	ATHB6	20,25	ABI1	ATHB6	828714(Tax:3702)	816775(Tax:3702)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis .
26443375	0	ABI1	81,85	MAPKKK18	33,41	ABI1	MAPKKK18	828714(Tax:3702)	839324(Tax:3702)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Arabidopsis ABA-activated kinase MAPKKK18 is regulated by protein phosphatase 2C ABI1 and the ubiquitin proteasome pathway .
12410810	0	ABI3	24,28	ABI5	0,4	ABI3	ABI5	822061(Tax:3702)	818199(Tax:3702)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	ABI5 acts downstream of ABI3 to execute an ABA-dependent growth_arrest during germination .
12662310	0	ABI3	33,37	ABSCISIC_ACID_INSENSITIVE_3	4,31	ABI3	ABSCISIC ACID INSENSITIVE 3	822061(Tax:3702)	822061(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The ABSCISIC_ACID_INSENSITIVE_3 -LRB- ABI3 -RRB- gene is modulated by farnesylation and is involved in auxin signaling and lateral root development in Arabidopsis .
16463099	0	ABI3	30,34	RD29B	71,76	ABI3	RD29B	822061(Tax:3702)	835306(Tax:3702)	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Transcriptional regulation of ABI3 - and ABA-responsive genes including RD29B and RD29A in seeds , germinating embryos , and seedlings of Arabidopsis .
21448003	0	ABI4	43,47	ABSCISIC_ACID_INSENSITIVE_4	14,41	ABI4	ABSCISIC ACID INSENSITIVE 4	818614(Tax:3702)	818614(Tax:3702)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ABSCISIC_ACID_INSENSITIVE_4 -LRB- ABI4 -RRB- in developing Arabidopsis seedlings .
21515696	0	ABI4	0,4	DGAT1	15,20	ABI4	DGAT1	818614(Tax:3702)	816464(Tax:3702)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nummod|END_ENTITY	ABI4 activates DGAT1 expression in Arabidopsis seedlings during nitrogen deficiency .
12410810	0	ABI5	0,4	ABI3	24,28	ABI5	ABI3	818199(Tax:3702)	822061(Tax:3702)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	ABI5 acts downstream of ABI3 to execute an ABA-dependent growth_arrest during germination .
26729600	0	ABI5	81,85	ABSCISIC_ACID_INSENSITIVE_5	52,79	ABI5	ABSCISIC ACID INSENSITIVE 5	818199(Tax:3702)	818199(Tax:3702)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The Arabidopsis DELAY OF GERMINATION 1 gene affects ABSCISIC_ACID_INSENSITIVE_5 -LRB- ABI5 -RRB- expression and genetically interacts with ABI3 during Arabidopsis seed development .
16684768	0	ABIN-1	0,6	A20	51,54	ABIN-1	A20	10318	28935	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB .
12586352	0	ABIN-1	83,89	NF-kappa_B	60,70	ABIN-1	NF-kappa B	10318	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Structure-function analysis of the A20-binding inhibitor of NF-kappa_B activation , ABIN-1 .
14653779	0	ABIN-2	14,20	IKKgamma	102,110	ABIN-2	IKKgamma	79155	8517	Gene	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|interaction interaction|nmod|END_ENTITY	The inhibitor ABIN-2 disrupts the interaction of receptor-interacting_protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis .
18081698	0	ABIN-3	38,44	NF-kappaB	124,133	ABIN-3	NF-kappaB	79931	4790	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF_and_toll-like_receptor_4 stimulation is itself regulated by NF-kappaB .
18081698	0	ABIN-3	38,44	TNF_and_toll-like_receptor_4	60,88	ABIN-3	TNF and toll-like receptor 4	79931	7124;7099	Gene	Gene	START_ENTITY|nmod|response response|nmod|stimulation stimulation|compound|END_ENTITY	Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF_and_toll-like_receptor_4 stimulation is itself regulated by NF-kappaB .
23117882	0	ABL	0,3	AXL	18,21	ABL	AXL	25	558	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	ABL regulation by AXL promotes cisplatin resistance in esophageal_cancer .
10526530	0	ABL	43,46	BCR	28,31	ABL	BCR	25	613	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Insertion of the 5 ' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic_myeloid_leukemia .
26126715	0	ABL	11,14	DGCR8	57,62	ABL	DGCR8	25	54487	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage .
19135771	0	ABL1	32,36	CD34	53,57	ABL1	CD34	25	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of P190 and P210_BCR / ABL1 in normal human CD34 -LRB- + -RRB- cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage .
24464651	0	ABL2	74,78	miR-20a	0,7	ABL2	miR-20a	27	406982	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-20a promotes prostate_cancer invasion and migration through targeting ABL2 .
17978851	0	ABORTED_MICROSPORES	124,143	ASHR3	35,40	ABORTED MICROSPORES	ASHR3	816194(Tax:3702)	829210(Tax:3702)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The Arabidopsis SET-domain protein ASHR3 is involved in stamen development and interacts with the bHLH transcription factor ABORTED_MICROSPORES -LRB- AMS -RRB- .
26600159	0	ABO_Blood_Group	50,65	Interleukin-10	84,98	ABO Blood Group	Interleukin-10	28	3586	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Genome-Wide Association Study Identifies That the ABO_Blood_Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute_Coronary_Syndrome .
12871537	0	ABO_blood_group	16,31	ADAMTS13	87,95	ABO blood group	ADAMTS13	28	11093	Gene	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	An influence of ABO_blood_group on the rate of proteolysis of von_Willebrand factor by ADAMTS13 .
21840304	0	ABO_blood_group	40,55	ADAMTS13	0,8	ABO blood group	ADAMTS13	28	11093	Gene	Gene	assessment|dep|START_ENTITY von_Willebrand|dobj|assessment von_Willebrand|nsubj|END_ENTITY	ADAMTS13 , FVIII , von_Willebrand factor , ABO_blood_group assessment in preeclampsia .
12573823	0	ABP	37,40	androgen-binding_protein	11,35	ABP	androgen-binding protein	24775(Tax:10116)	24775(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of androgen-binding_protein -LRB- ABP -RRB- on spermatid Tnp1 gene expression in vitro .
16700002	0	ABP	40,43	androgen-binding_protein	14,38	ABP	androgen-binding protein	6462	6462	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of androgen-binding_protein -LRB- ABP -RRB- in human cardiac myocytes .
3135485	0	ABP	53,56	androgen-binding_protein	27,51	ABP	androgen-binding protein	24775(Tax:10116)	24775(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Hormonal regulation of rat androgen-binding_protein -LRB- ABP -RRB- messenger ribonucleic acid and homology of human testosterone-estradiol-binding globulin and ABP complementary deoxyribonucleic acids .
3604700	0	ABP	85,88	hCG	16,19	ABP	hCG	24775(Tax:10116)	3342	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Acute effect of hCG on testicular and epididymal levels of androgen_binding_protein -LRB- ABP -RRB- in the immature rat .
7534799	0	ABP-280	31,38	CD18	73,77	ABP-280	CD18	2318	3689	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of filamin -LRB- ABP-280 -RRB- with the beta_2-integrin subunit CD18 .
11482904	0	ABP-280	28,35	filamin	19,26	ABP-280	filamin	2318	2318	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of filamin -LRB- ABP-280 -RRB- regulates the binding to the lipid membrane , integrin , and actin .
7534799	0	ABP-280	31,38	filamin	22,29	ABP-280	filamin	2318	2318	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of filamin -LRB- ABP-280 -RRB- with the beta_2-integrin subunit CD18 .
11389901	0	ABP-280	42,49	filamin_A	31,40	ABP-280	filamin A	2316	2316	Gene	Gene	molecules|compound|START_ENTITY molecules|compound|END_ENTITY	Mechanical unfolding of single filamin_A -LRB- ABP-280 -RRB- molecules detected by atomic force microscopy .
12662310	0	ABSCISIC_ACID_INSENSITIVE_3	4,31	ABI3	33,37	ABSCISIC ACID INSENSITIVE 3	ABI3	822061(Tax:3702)	822061(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The ABSCISIC_ACID_INSENSITIVE_3 -LRB- ABI3 -RRB- gene is modulated by farnesylation and is involved in auxin signaling and lateral root development in Arabidopsis .
21448003	0	ABSCISIC_ACID_INSENSITIVE_4	14,41	ABI4	43,47	ABSCISIC ACID INSENSITIVE 4	ABI4	818614(Tax:3702)	818614(Tax:3702)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ABSCISIC_ACID_INSENSITIVE_4 -LRB- ABI4 -RRB- in developing Arabidopsis seedlings .
26729600	0	ABSCISIC_ACID_INSENSITIVE_5	52,79	ABI5	81,85	ABSCISIC ACID INSENSITIVE 5	ABI5	818199(Tax:3702)	818199(Tax:3702)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The Arabidopsis DELAY OF GERMINATION 1 gene affects ABSCISIC_ACID_INSENSITIVE_5 -LRB- ABI5 -RRB- expression and genetically interacts with ABI3 during Arabidopsis seed development .
15026181	0	AC-4	34,38	adenylyl_cyclase-4	14,32	AC-4	adenylyl cyclase-4	104110(Tax:10090)	104110(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of adenylyl_cyclase-4 -LRB- AC-4 -RRB- in Y1 and forskolin-resistant adrenal cells .
10456440	0	AC133	24,29	CD34	18,22	AC133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Ex vivo expansion CD34 + / AC133 + - selected autologous peripheral blood progenitor cells -LRB- PBPC -RRB- in high-risk breast_cancer patients receiving intensive chemotherapy .
10580405	0	AC133	74,79	CD34	69,73	AC133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Human_immunodeficiency_virus_infection of human placental cord blood CD34 + AC133 + stem cells and their progeny .
10985471	0	AC133	66,71	CD34	73,77	AC133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY differentiation|nmod|+ differentiation|parataxis|selected selected|nsubj|cells cells|compound|END_ENTITY	Myeloid differentiation and maturation of SCF+IL -3 + IL-11 expanded AC133 + / CD34 + cells selected from high-risk breast_cancer patients .
11177594	0	AC133	124,129	CD34	159,163	AC133	CD34	8842	947	Gene	Gene	CD34|compound|START_ENTITY potential|nmod|CD34 based|nmod|potential cells|acl|based hierarchy|nmod|cells hierarchy|dep|+ +|compound|END_ENTITY	A functional hierarchy among the CD34 + hematopoietic cells based on in vitro proliferative and differentiative potential of AC133 + CD34 -LRB- bright -RRB- and AC133 -LRB- dim / -RRB- - CD34 + human cord blood cells .
11177594	0	AC133	124,129	CD34	33,37	AC133	CD34	8842	947	Gene	Gene	CD34|compound|START_ENTITY potential|nmod|CD34 based|nmod|potential cells|acl|based cells|nummod|END_ENTITY	A functional hierarchy among the CD34 + hematopoietic cells based on in vitro proliferative and differentiative potential of AC133 + CD34 -LRB- bright -RRB- and AC133 -LRB- dim / -RRB- - CD34 + human cord blood cells .
12002675	0	AC133	89,94	CD34	96,100	AC133	CD34	8842	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
17588480	0	AC133	11,16	CD34	6,10	AC133	CD34	8842	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD34 + AC133 + VEGFR-2 + cells are not endothelial progenitor cells but distinct , primitive hematopoietic progenitors .
19379577	0	AC133	56,61	CXCR4	18,23	AC133	CXCR4	8842	7852	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Effects of SDF-1 / CXCR4 on the chemotaxis of cord blood AC133 -LRB- + -RRB- cells -RSB- .
12002675	0	AC133	89,94	IL-3	23,27	AC133	IL-3	8842	3562	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells influence|nmod|proliferation influence|nsubj|FLT3L FLT3L|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
12002675	0	AC133	89,94	SCF	30,33	AC133	SCF	8842	4254	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells influence|nmod|proliferation influence|nsubj|FLT3L FLT3L|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
17588480	0	AC133	11,16	VEGFR-2	17,24	AC133	VEGFR-2	8842	3791	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD34 + AC133 + VEGFR-2 + cells are not endothelial progenitor cells but distinct , primitive hematopoietic progenitors .
20664520	0	AC2	67,70	RXFP1	52,57	AC2	RXFP1	108	59350	Gene	Gene	complex|dep|START_ENTITY complex|compound|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
20664520	0	AC2	67,70	beta-arrestin_2	72,87	AC2	beta-arrestin 2	108	409	Gene	Gene	complex|dep|START_ENTITY complex|amod|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
20680465	0	AC3-33	0,6	Elk1	44,48	AC3-33	Elk1	285315	2002	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	AC3-33 , a novel secretory protein , inhibits Elk1 transcriptional activity via ERK pathway .
22613711	0	AC8	93,96	adenylyl_cyclase_8	73,91	AC8	adenylyl cyclase 8	29241(Tax:10116)	29241(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The Notch pathway attenuates interleukin_1b -LRB- IL1b -RRB- - mediated induction of adenylyl_cyclase_8 -LRB- AC8 -RRB- expression during vascular smooth muscle cell -LRB- VSMC -RRB- trans-differentiation .
17458235	0	ACAM	1,5	vaspin	7,13	ACAM	vaspin	79827	145264	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- ACAM , vaspin -RSB- .
19189937	0	ACAT1	25,30	TNF-alpha	0,9	ACAT1	TNF-alpha	38	7124	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation .
12754704	0	ACAT1/T2	96,104	acetoacetyl-CoA_thiolase	70,94	ACAT1/T2	acetoacetyl-CoA thiolase	38	38	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single base substitutions at the initiator codon in the mitochondrial acetoacetyl-CoA_thiolase -LRB- ACAT1/T2 -RRB- gene result in production of varying amounts of wild-type T2 polypeptide .
15805543	0	ACAT2	0,5	VLDL	55,59	ACAT2	VLDL	110460(Tax:10090)	54219(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	ACAT2 contributes cholesteryl_esters to newly secreted VLDL , whereas LCAT adds cholesteryl_ester to LDL in mice .
11267899	0	ACBP	46,50	acyl-CoA-binding_protein	20,44	ACBP	acyl-CoA-binding protein	692574(Tax:7091)	692574(Tax:7091)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of acyl-CoA-binding_protein -LRB- ACBP -RRB- in the pheromone gland of the silkworm , Bombyx_mori .
17262885	0	ACBP	41,45	acyl-CoA-binding_protein	15,39	ACBP	acyl-CoA-binding protein	1622	1622	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of acyl-CoA-binding_protein -LRB- ACBP -RRB- single nucleotide polymorphisms and type_2_diabetes in two German study populations .
20079838	0	ACBP	49,53	acyl-CoA-binding_protein	23,47	ACBP	acyl-CoA-binding protein	1622	1622	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Serotonin regulates an acyl-CoA-binding_protein -LRB- ACBP -RRB- gene expression in the midgut of Rhodnius prolixus .
21079819	0	ACBP	104,108	acyl-CoA-binding_protein	78,102	ACBP	acyl-CoA-binding protein	1622	1622	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Expression , purification and functional characterization of recombinant human acyl-CoA-binding_protein -LRB- ACBP -RRB- from erythroid cells .
8232254	0	ACBP	42,46	acyl-CoA-binding_protein	16,40	ACBP	acyl-CoA-binding protein	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	The function of acyl-CoA-binding_protein -LRB- ACBP -RRB- / diazepam_binding_inhibitor -LRB- DBI -RRB- .
18178100	0	ACBP	114,118	acyl_coenzyme_A_binding_protein	81,112	ACBP	acyl coenzyme A binding protein	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Structural and functional characterization of a new recombinant histidine-tagged acyl_coenzyme_A_binding_protein -LRB- ACBP -RRB- from mouse .
18823312	0	ACBP2	46,51	AtFP6	108,113	ACBP2	AtFP6	828891(Tax:3702)	830015(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arabidopsis_thaliana acyl-CoA-binding protein ACBP2 interacts with heavy-metal-binding farnesylated protein AtFP6 .
18605443	0	ACC-2	117,122	basic_fibroblast_growth_factor	12,42	ACC-2	basic fibroblast growth factor	597	2247	Gene	Gene	Effects|amod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of basic_fibroblast_growth_factor on the proliferation of human salivary adenoid_cystic_carcinoma cell line ACC-2 and extracellular_signal-regulated_kinase , Cyclin_D1 , p2waf/cip1 signaling pathway -RSB- .
18349698	0	ACCN2	70,75	amiloride-sensitive_cation_channel_2	32,68	ACCN2	amiloride-sensitive cation channel 2	41	41	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between the amiloride-sensitive_cation_channel_2 -LRB- ACCN2 -RRB- gene and anxiety_spectrum_disorders .
15494558	0	ACCUMULATION_OF_PHOTOSYSTEM_ONE1	0,32	accumulation	83,95	ACCUMULATION OF PHOTOSYSTEM ONE1	accumulation	842789(Tax:3702)	842789(Tax:3702)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	ACCUMULATION_OF_PHOTOSYSTEM_ONE1 , a member of a novel gene family , is required for accumulation of -LSB- 4Fe-4S -RSB- cluster-containing chloroplast complexes and antenna proteins .
14507999	0	ACD6	0,4	ankyrin	14,21	ACD6	ankyrin	827085(Tax:3702)	835550(Tax:3702)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	ACD6 , a novel ankyrin protein , is a regulator and an effector of salicylic_acid signaling in the Arabidopsis defense response .
16324920	0	ACDC	47,51	adiponectin	34,45	ACDC	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The SNP276G > T polymorphism in the adiponectin -LRB- ACDC -RRB- gene is more strongly associated with insulin resistance and cardiovascular_disease risk than SNP45T > G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin .
10874261	0	ACE	21,24	ACE	60,63	ACE	ACE	1636	1636	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Dissociation between ACE activity and autonomic response to ACE inhibition in patients with heart_failure .
10874261	0	ACE	60,63	ACE	21,24	ACE	ACE	1636	1636	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Dissociation between ACE activity and autonomic response to ACE inhibition in patients with heart_failure .
8569988	0	ACE	31,34	ACE	67,70	ACE	ACE	1636	1636	Gene	Gene	polymorphisms|appos|START_ENTITY END_ENTITY|nsubj|polymorphisms	Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphisms , angiotensin_II , ACE inhibitors and glomerulosclerosis -- a hypothesis .
8569988	0	ACE	67,70	ACE	31,34	ACE	ACE	1636	1636	Gene	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphisms , angiotensin_II , ACE inhibitors and glomerulosclerosis -- a hypothesis .
15231706	0	ACE	41,44	ACE2	55,59	ACE	ACE2	24310(Tax:10116)	302668(Tax:10116)	Gene	Gene	homolog|appos|START_ENTITY homolog|appos|END_ENTITY	The novel angiotensin-converting enzyme -LRB- ACE -RRB- homolog , ACE2 , is selectively expressed by adult Leydig cells of the testis .
17303661	0	ACE	140,143	ACE2	147,151	ACE	ACE2	1636	59272	Gene	Gene	hypertension|nmod|START_ENTITY expression|nmod|hypertension expression|nmod|ratio ratio|compound|END_ENTITY	Synergistic expression of angiotensin-converting_enzyme -LRB- ACE -RRB- and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio .
17303661	0	ACE	57,60	ACE2	147,151	ACE	ACE2	1636	59272	Gene	Gene	angiotensin-converting_enzyme|appos|START_ENTITY expression|nmod|angiotensin-converting_enzyme expression|nmod|ratio ratio|compound|END_ENTITY	Synergistic expression of angiotensin-converting_enzyme -LRB- ACE -RRB- and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio .
17579661	0	ACE	72,75	ACE2	0,4	ACE	ACE2	11421(Tax:10090)	70008(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression inhibition|nsubj|END_ENTITY	ACE2 inhibition worsens_glomerular_injury in association with increased ACE expression in streptozotocin-induced diabetic mice .
18192334	0	ACE	85,88	ACE2	73,77	ACE	ACE2	24310(Tax:10116)	302668(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Differential regulation of renal angiotensin-converting enzyme -LRB- ACE -RRB- and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats .
19698082	0	ACE	87,90	ACE2	19,23	ACE	ACE2	24310(Tax:10116)	302668(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY ameliorated|nmod|inhibition ameliorated|nsubjpass|Reduction Reduction|nmod|expression expression|compound|END_ENTITY	Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition .
22800722	0	ACE	54,57	ACE2	60,64	ACE	ACE2	1636	59272	Gene	Gene	angiotensin-I-converting_enzyme|appos|START_ENTITY angiotensin-I-converting_enzyme|appos|END_ENTITY	Three key proteases -- angiotensin-I-converting_enzyme -LRB- ACE -RRB- , ACE2 and renin -- within and beyond the renin-angiotensin system .
26016560	0	ACE	27,30	ACE2	64,68	ACE	ACE2	24310(Tax:10116)	302668(Tax:10116)	Gene	Gene	peptide|nsubj|START_ENTITY peptide|ccomp|END_ENTITY	Egg ovotransferrin-derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats .
26162198	0	ACE	149,152	Angiotensin-1_Converting_Enzyme	116,147	ACE	Angiotensin-1 Converting Enzyme	1636	1636	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Heterogeneity of Physical Function Responses to Exercise in Older Adults : Possible Contribution of Variation in the Angiotensin-1_Converting_Enzyme -LRB- ACE -RRB- Gene ?
21331722	0	ACE	49,52	Angiotensin-Converting_Enzyme	18,47	ACE	Angiotensin-Converting Enzyme	1636	1636	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Quantification of Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Activity .
25807210	0	ACE	45,48	Angiotensin-Converting_Enzyme	15,44	ACE	Angiotensin-Converting Enzyme	1636	1636	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Association of Angiotensin-Converting_Enzyme ACE Gene Polymorphism with ACE Activity and Susceptibility to Vitiligo in Egyptian Population .
26177100	0	ACE	46,49	Angiotensin-Converting_Enzyme	15,44	ACE	Angiotensin-Converting Enzyme	1636	1636	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Gene Polymorphism with Inflammation and Cellular Cytotoxicity in Vitiligo Patients .
26180887	0	ACE	31,34	Angiotensin-Converting_Enzyme	0,29	ACE	Angiotensin-Converting Enzyme	1636	1636	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Inhibitors : A Review of the Comparative Clinical and Cost-Effectiveness This purpose of this report is to update a 2008 CADTH Rapid Response report on the comparative clinical and cost-effectiveness of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
20479968	0	ACE	33,36	Angiotensin-I-converting_enzyme	0,31	ACE	Angiotensin-I-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Angiotensin-I-converting_enzyme -LRB- ACE -RRB- inhibitors from marine resources : prospects in the pharmaceutical industry .
11168787	0	ACE	31,34	Angiotensin-converting_enzyme	0,29	ACE	Angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- gene polymorphisms and familial occurrence of sarcoidosis .
16395257	0	ACE	31,34	Angiotensin-converting_enzyme	0,29	ACE	Angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition in type 2 , diabetic patients -- interaction with ACE insertion/deletion polymorphism .
20600611	0	ACE	31,34	Angiotensin-converting_enzyme	0,29	ACE	Angiotensin-converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors exacerbate histological damage and motor_deficits after experimental traumatic_brain_injury .
8046841	0	ACE	32,35	Angiotensin-converting_enzyme	1,30	ACE	Angiotensin-converting enzyme	1636	1636	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	-LSB- Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphism and serum ACE activities in sarcoidosis -RSB- .
8573745	0	ACE	31,34	Angiotensin-converting_enzyme	0,29	ACE	Angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- gene polymorphism in type II diabetic patients with increased albumin excretion rate .
15950509	0	ACE	54,57	Angiotensin_Converting_Enzyme	23,52	ACE	Angiotensin Converting Enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No association between Angiotensin_Converting_Enzyme -LRB- ACE -RRB- gene variation and endurance athlete status in Kenyans .
25922179	0	ACE	126,129	Angiotensin_Converting_Enzyme	95,124	ACE	Angiotensin Converting Enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin_Converting_Enzyme -LRB- ACE -RRB- inhibitors .
12566298	0	ACE	33,36	Angiotensin_I-converting_enzyme	0,31	ACE	Angiotensin I-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene polymorphism and breast_cancer risk among Chinese women in Singapore .
21495912	0	ACE	33,36	Angiotensin_I-converting_enzyme	0,31	ACE	Angiotensin I-converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Angiotensin_I-converting_enzyme -LRB- ACE -RRB- activity and expression in rat central nervous system after sleep_deprivation .
21496083	0	ACE	70,73	Angiotensin_I-converting_enzyme	37,68	ACE	Angiotensin I-converting enzyme	100064801(Tax:9796)	100064801(Tax:9796)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of two training protocols on Angiotensin_I-converting_enzyme -LRB- ACE -RRB- activity in horses .
10755201	0	ACE	60,63	Angiotensin_II	0,14	ACE	Angiotensin II	1636	183	Gene	Gene	inhibition|compound|START_ENTITY vasculature|nmod|inhibition formation|nmod|vasculature formation|compound|END_ENTITY	Angiotensin_II formation in human vasculature after chronic ACE inhibition : a prospective , randomized , placebo-controlled study .
1660550	0	ACE	82,85	Angiotensin_II	0,14	ACE	Angiotensin II	1636	183	Gene	Gene	inhibition|compound|START_ENTITY reverse|nmod|inhibition reverse|nsubj|END_ENTITY	Angiotensin_II does not acutely reverse the reduction of proteinuria by long-term ACE inhibition .
18403595	0	ACE	61,64	Angiotensin_II	0,14	ACE	Angiotensin II	1636	183	Gene	Gene	angiotensin_I-converting_enzyme|appos|START_ENTITY up-regulates|dobj|angiotensin_I-converting_enzyme up-regulates|nsubj|END_ENTITY	Angiotensin_II up-regulates angiotensin_I-converting_enzyme -LRB- ACE -RRB- , but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway .
9362242	0	ACE	30,33	Angiotensin_II	0,14	ACE	Angiotensin II	1636	183	Gene	Gene	formation|nmod|START_ENTITY formation|compound|END_ENTITY	Angiotensin_II formation from ACE and chymase in human and animal hearts : methods and species considerations .
9800878	0	ACE	48,51	Angiotensin_II	0,14	ACE	Angiotensin II	1636	183	Gene	Gene	formation|dep|START_ENTITY formation|compound|END_ENTITY	Angiotensin_II formation in the human heart : an ACE or non-ACE-mediated pathway ?
7734106	0	ACE	33,36	Angiotensin_I_converting_enzyme	0,31	ACE	Angiotensin I converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene polymorphism and essential hypertension in Japan .
23920063	0	ACE	29,32	Erythropoietin	0,14	ACE	Erythropoietin	24310(Tax:10116)	24335(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	Erythropoietin combined with ACE inhibitor prevents heart remodeling in 5/6 nephrectomized rats independently of blood pressure and kidney function .
11139436	0	ACE	31,34	IGF-I	88,93	ACE	IGF-I	24310(Tax:10116)	24482(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Angiotensin-converting enzyme -LRB- ACE -RRB- inhibition attenuates insulin-like_growth_factor-I -LRB- IGF-I -RRB- induced cardiac fibroblast proliferation .
20614101	0	ACE	17,20	Leptin	0,6	ACE	Leptin	11421(Tax:10090)	16846(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Leptin regulates ACE activity in mice .
19355890	0	ACE	52,55	MMP-9	32,37	ACE	MMP-9	1636	4318	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Pharmacological implications of MMP-9 inhibition by ACE inhibitors .
20093780	0	ACE	20,23	MMP-9	0,5	ACE	MMP-9	1636	4318	Gene	Gene	inhibitor|compound|START_ENTITY inhibition|nmod|inhibitor inhibition|compound|END_ENTITY	MMP-9 inhibition by ACE inhibitor reduces oxidized LDL-mediated foam-cell formation .
9660395	0	ACE	0,3	MTHFR	5,10	ACE	MTHFR	1636	4524	Gene	Gene	polymorphisms|advmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	ACE , MTHFR , factor_V_Leiden , and APOE polymorphisms in patients with vascular and Alzheimer 's _ dementia .
18706898	0	ACE	141,144	angiotensin-I-converting_enzyme	108,139	ACE	angiotensin-I-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting_enzyme -LRB- ACE -RRB- gene in Mexican patients and binary restenosis after coronary stenting .
23271625	0	ACE	47,50	angiotensin-I-converting_enzyme	14,45	ACE	angiotensin-I-converting enzyme	1636	1636	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Review on the angiotensin-I-converting_enzyme -LRB- ACE -RRB- inhibitor peptides from marine proteins .
23056909	0	ACE	79,82	angiotensin-I_converting_enzyme	46,77	ACE	angiotensin-I converting enzyme	1636	1636	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Molecular recognition and regulation of human angiotensin-I_converting_enzyme -LRB- ACE -RRB- activity by natural inhibitory peptides .
8730292	0	ACE	37,40	angiotensin-I_converting_enzyme	4,35	ACE	angiotensin-I converting enzyme	1636	1636	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The angiotensin-I_converting_enzyme -LRB- ACE -RRB- gene I/D polymorphism and ACE levels in Pima Indians .
7723869	0	ACE	80,83	angiotensin-converting-enzyme	49,78	ACE	angiotensin-converting-enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- Life-threatening angioedema as a side effect of angiotensin-converting-enzyme -LRB- ACE -RRB- inhibitors -RSB- .
9872248	0	ACE	41,44	angiotensin-converting-enzyme	10,39	ACE	angiotensin-converting-enzyme	1636	1636	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of angiotensin-converting-enzyme -LRB- ACE -RRB- inhibitor trandolapril on human diabetic_neuropathy : randomised double-blind controlled trial .
10536692	0	ACE	65,68	angiotensin-converting_enzyme	34,63	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Chronic AT1 receptor blockade and angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition in -LRB- CHF 146 -RRB- cardiomyopathic hamsters : effects on cardiac_hypertrophy and survival .
10593661	0	ACE	56,59	angiotensin-converting_enzyme	25,54	ACE	angiotensin-converting enzyme	610668(Tax:9615)	610668(Tax:9615)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Functional role of local angiotensin-converting_enzyme -LRB- ACE -RRB- in adrenal catecholamine secretion in vivo .
10694521	0	ACE	62,65	angiotensin-converting_enzyme	31,60	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Maximally recommended doses of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors do not completely prevent ACE-mediated formation of angiotensin_II in chronic_heart_failure .
10790965	0	ACE	43,46	angiotensin-converting_enzyme	12,41	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors on water-salt homeostasis in hypertensive patients living in Far North -RSB- .
10938492	0	ACE	60,63	angiotensin-converting_enzyme	29,58	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	First-dose hypotension after angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors in chronic_heart_failure : a comparison of enalapril and perindopril .
11043512	0	ACE	118,121	angiotensin-converting_enzyme	87,116	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting_enzyme -LRB- ACE -RRB- gene .
11377823	0	ACE	51,54	angiotensin-converting_enzyme	20,49	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Linkage analysis of angiotensin-converting_enzyme -LRB- ACE -RRB- insertion/deletion polymorphism and systemic_lupus_erythematosus .
11464681	0	ACE	79,82	angiotensin-converting_enzyme	48,77	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	-LSB- Acute_renal_failure , renal_artery_stenosis and angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor -RSB- .
12135325	0	ACE	59,62	angiotensin-converting_enzyme	28,57	ACE	angiotensin-converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Combination therapy with an angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor and a calcium antagonist : beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal_ablation .
12138046	2	ACE	155,158	angiotensin-converting_enzyme	124,153	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	My physician initially prescribed lisinopril , an angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor .
12209028	0	ACE	81,84	angiotensin-converting_enzyme	50,79	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Prevention of vascular_damage in scleroderma with angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition .
12677950	0	ACE	58,61	angiotensin-converting_enzyme	27,56	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Familial hyperactivity of angiotensin-converting_enzyme -LRB- ACE -RRB- -RSB- .
1290300	0	ACE	48,51	angiotensin-converting_enzyme	17,46	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- Prevention with angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors -RSB- .
15071363	0	ACE	53,56	angiotensin-converting_enzyme	22,51	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Gender differences in angiotensin-converting_enzyme -LRB- ACE -RRB- activity and inhibition by enalaprilat in healthy volunteers .
15109972	0	ACE	81,84	angiotensin-converting_enzyme	50,79	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphic locus in the intron 16 of the human angiotensin-converting_enzyme -LRB- ACE -RRB- gene is not correlated with complex_regional_pain_syndrome_I -LRB- CRPS_I -RRB- .
1580276	0	ACE	47,50	angiotensin-converting_enzyme	16,45	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Blood pressure , angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors , and the kidney .
1580277	0	ACE	43,46	angiotensin-converting_enzyme	12,41	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	A decade of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition .
1646329	0	ACE	52,55	angiotensin-converting_enzyme	21,50	ACE	angiotensin-converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Effects of different angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors on ischemic isolated rat hearts : relationship between cardiac ACE inhibition and cardioprotection .
16900885	0	ACE	70,73	angiotensin-converting_enzyme	39,68	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Insertion-deletion polymorphism in the angiotensin-converting_enzyme -LRB- ACE -RRB- gene among Sudanese , Somalis , Emiratis , and Omanis .
17164796	0	ACE	50,53	angiotensin-converting_enzyme	19,48	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No contribution of angiotensin-converting_enzyme -LRB- ACE -RRB- gene variants to severe obesity : a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases .
17713861	0	ACE	46,49	angiotensin-converting_enzyme	15,44	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of angiotensin-converting_enzyme -LRB- ACE -RRB- gene insertion-deletion polymorphism with spondylarthropathies .
20162537	0	ACE	114,117	angiotensin-converting_enzyme	83,112	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Development of a fast liquid chromatography/mass spectrometry screening method for angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors in complex natural mixtures like snake venom .
21116821	0	ACE	65,68	angiotensin-converting_enzyme	34,63	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Adipocyte-derived lipids increase angiotensin-converting_enzyme -LRB- ACE -RRB- expression and modulate macrophage phenotype .
21467797	0	ACE	93,96	angiotensin-converting_enzyme	62,91	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	-LSB- Pharmacoeconomic evaluation of hypothetical over-the-counter angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors for the prevention of stroke in patients with grade I hypertension -RSB- .
2164636	0	ACE	59,62	angiotensin-converting_enzyme	28,57	ACE	angiotensin-converting enzyme	11421(Tax:10090)	11421(Tax:10090)	Gene	Gene	Transcription|appos|START_ENTITY Transcription|nmod|END_ENTITY	Transcription of testicular angiotensin-converting_enzyme -LRB- ACE -RRB- is initiated within the 12th intron of the somatic ACE gene .
23390188	0	ACE	58,61	angiotensin-converting_enzyme	27,56	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Gender difference of serum angiotensin-converting_enzyme -LRB- ACE -RRB- activity in DD genotype of ACE insertion/deletion polymorphism in elderly Chinese .
23741507	0	ACE	70,73	angiotensin-converting_enzyme	39,68	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms of the angiotensin-converting_enzyme -LRB- ACE -RRB- gene are associated with essential hypertension and increased ACE enzyme levels in Mexican individuals .
23973719	0	ACE	69,72	angiotensin-converting_enzyme	38,67	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	Gene|appos|START_ENTITY Gene|amod|END_ENTITY	The importance of association between angiotensin-converting_enzyme -LRB- ACE -RRB- Gene I/D polymorphism and diabetic_peripheral_neuropathy .
24995885	0	ACE	49,52	angiotensin-converting_enzyme	18,47	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotypes of the angiotensin-converting_enzyme -LRB- ACE -RRB- gene are associated with coronary_artery_disease but not with restenosis after coronary stenting .
25957986	0	ACE	69,72	angiotensin-converting_enzyme	38,67	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Short-term storage stability of serum angiotensin-converting_enzyme -LRB- ACE -RRB- activity .
25957986	0	ACE	69,72	angiotensin-converting_enzyme	38,67	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Short-term storage stability of serum angiotensin-converting_enzyme -LRB- ACE -RRB- activity .
6099390	0	ACE	59,62	angiotensin-converting_enzyme	28,57	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Effect of dietary sodium on angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition and the acute hypotensive effect of enalapril -LRB- MK-421 -RRB- in essential hypertension .
7559159	0	ACE	42,45	angiotensin-converting_enzyme	11,40	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of angiotensin-converting_enzyme -LRB- ACE -RRB- from human spermatozoa during capacitation and acrosome reaction .
8256319	0	ACE	104,107	angiotensin-converting_enzyme	73,102	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- Optimal treatment of chronic heart_failure -- with particular emphasis on angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors -RSB- .
8380220	0	ACE	60,63	angiotensin-converting_enzyme	29,58	ACE	angiotensin-converting enzyme	11421(Tax:10090)	11421(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Sperm-specific expression of angiotensin-converting_enzyme -LRB- ACE -RRB- is mediated by a 91-base-pair promoter containing a CRE-like element .
9230757	0	ACE	51,54	angiotensin-converting_enzyme	20,49	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the angiotensin-converting_enzyme -LRB- ACE -RRB- gene and sarcoidosis .
9503533	0	ACE	165,168	angiotensin-converting_enzyme	134,163	ACE	angiotensin-converting enzyme	1636	1636	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Change of circadian pattern of arterial pressure in patients with congestive_heart_failure treated with perindopril , an inhibitor of angiotensin-converting_enzyme -LRB- ACE -RRB- -RSB- .
17676311	0	ACE	91,94	angiotensin_I	33,46	ACE	angiotensin I	1636	183	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Gradual reactivation of vascular angiotensin_I to angiotensin_II conversion during chronic ACE inhibitor therapy in patients with diabetes_mellitus .
10506486	0	ACE	57,60	angiotensin_I-converting_enzyme	24,55	ACE	angiotensin I-converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sustained inhibition of angiotensin_I-converting_enzyme -LRB- ACE -RRB- expression and long-term antihypertensive action by virally mediated delivery of ACE antisense cDNA .
1319114	0	ACE	113,116	angiotensin_I-converting_enzyme	80,111	ACE	angiotensin I-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence , from combined segregation and linkage analysis , that a variant of the angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene controls plasma ACE levels .
15720304	0	ACE	55,58	angiotensin_I-converting_enzyme	22,53	ACE	angiotensin I-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SNP haplotypes in the angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene : analysis of Nigerian family data using gamete competition models .
20214946	0	ACE	71,74	angiotensin_I-converting_enzyme	38,69	ACE	angiotensin I-converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Arachin derived peptides as selective angiotensin_I-converting_enzyme -LRB- ACE -RRB- inhibitors : structure-activity relationship .
20518725	0	ACE	164,167	angiotensin_I-converting_enzyme	131,162	ACE	angiotensin I-converting enzyme	1636	1636	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Migraine_and_coronary_artery_disease : an open study on the genetic polymorphism of the 5 , 10 methylenetetrahydrofolate -LRB- MTHFR -RRB- and angiotensin_I-converting_enzyme -LRB- ACE -RRB- genes .
21895753	0	ACE	62,65	angiotensin_I-converting_enzyme	29,60	ACE	angiotensin I-converting enzyme	100064801(Tax:9796)	1636	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of acute exercise on angiotensin_I-converting_enzyme -LRB- ACE -RRB- activity in horses .
23560051	0	ACE	65,68	angiotensin_I-converting_enzyme	32,63	ACE	angiotensin I-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel splice-site mutation in angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene , c. 3691 +1 G > A -LRB- IVS25 +1 G > A -RRB- , causes a dramatic increase in circulating ACE through deletion of the transmembrane anchor .
23561096	0	ACE	142,145	angiotensin_I-converting_enzyme	109,140	ACE	angiotensin I-converting enzyme	1636	1636	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Simulated digestion of proanthocyanidins in grape skin and seed extracts and the effects of digestion on the angiotensin_I-converting_enzyme -LRB- ACE -RRB- inhibitory activity .
8651305	0	ACE	76,79	angiotensin_I-converting_enzyme	43,74	ACE	angiotensin I-converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of new polymorphisms of the angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene , and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis .
10361449	0	ACE	128,131	angiotensin_II	13,27	ACE	angiotensin II	1636	183	Gene	Gene	chronic_heart_failure|nmod|START_ENTITY inhibitors|amod|chronic_heart_failure treatment|nmod|inhibitors drug|nmod|treatment antagonists|nmod|drug antagonists|amod|END_ENTITY	-LSB- Efficacy of angiotensin_II receptor antagonists as a novel drug for the treatment of chronic_heart_failure -- in comparison with ACE inhibitors -RSB- .
10377310	0	ACE	82,85	angiotensin_II	14,28	ACE	angiotensin II	1636	183	Gene	Gene	treatment|compound|START_ENTITY raised|nmod|treatment raised|nsubjpass|concentrations concentrations|compound|END_ENTITY	How often are angiotensin_II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac_failure ?
10610744	0	ACE	65,68	angiotensin_II	42,56	ACE	angiotensin II	1636	183	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Clinical implications of increased plasma angiotensin_II despite ACE inhibitor therapy in patients with congestive_heart_failure .
10690317	0	ACE	59,62	angiotensin_II	35,49	ACE	angiotensin II	1636	183	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Vasoconstriction by in situ formed angiotensin_II : role of ACE and chymase .
10694521	0	ACE	62,65	angiotensin_II	130,144	ACE	angiotensin II	1636	183	Gene	Gene	inhibitors|appos|START_ENTITY doses|nmod|inhibitors prevent|nsubj|doses prevent|dobj|formation formation|nmod|END_ENTITY	Maximally recommended doses of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors do not completely prevent ACE-mediated formation of angiotensin_II in chronic_heart_failure .
11263608	0	ACE	31,34	angiotensin_II	58,72	ACE	angiotensin II	1636	183	Gene	Gene	Angiotensin_converting_enzyme|dep|START_ENTITY Angiotensin_converting_enzyme|dobj|generation generation|compound|END_ENTITY	Angiotensin_converting_enzyme -LRB- ACE -RRB- and non-ACE dependent angiotensin_II generation in resistance arteries from patients with heart_failure and coronary_heart_disease .
11774115	0	ACE	23,26	angiotensin_II	104,118	ACE	angiotensin II	24310(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY combining|dobj|inhibitor combining|nmod|levels levels|amod|END_ENTITY	Effect of combining an ACE inhibitor and an angiotensin_II receptor blocker on plasma and kidney tissue angiotensin_II levels .
1462860	0	ACE	20,23	angiotensin_II	82,96	ACE	angiotensin II	1636	183	Gene	Gene	inhibitor|compound|START_ENTITY Cardioprotection|nmod|inhibitor dependent|nsubj|Cardioprotection dependent|nmod|formation formation|compound|END_ENTITY	Cardioprotection of ACE inhibitor in ischemic heart is not dependent on the local angiotensin_II formation .
14984722	0	ACE	53,56	angiotensin_II	72,86	ACE	angiotensin II	24310(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|antagonism antagonism|amod|END_ENTITY	Endothelial_dysfunction in congestive_heart_failure : ACE inhibition vs. angiotensin_II antagonism .
16337046	0	ACE	97,100	angiotensin_II	26,40	ACE	angiotensin II	1636	183	Gene	Gene	inhibition|compound|START_ENTITY increased|nmod|inhibition increased|dobj|levels levels|amod|END_ENTITY	Determinants of increased angiotensin_II levels in severe chronic_heart_failure patients despite ACE inhibition .
16387160	0	ACE	15,18	angiotensin_II	39,53	ACE	angiotensin II	1636	183	Gene	Gene	effects|nmod|START_ENTITY inhibition|nsubj|effects inhibition|nmod|concentration concentration|compound|END_ENTITY	The effects of ACE inhibition on serum angiotensin_II concentration following cardiac transplantation .
16810285	0	ACE	0,3	angiotensin_II	54,68	ACE	angiotensin II	1636	183	Gene	Gene	START_ENTITY|dep|role role|acl|balance balance|dobj|expression expression|nmod|END_ENTITY	ACE and ACE2 : their role to balance the expression of angiotensin_II and angiotensin - -LRB- 1-7 -RRB- .
1689424	0	ACE	79,82	angiotensin_II	57,71	ACE	angiotensin II	1636	183	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Reactive hyperreninemia is a major determinant of plasma angiotensin_II during ACE inhibition .
17466950	0	ACE	10,13	angiotensin_II	28,42	ACE	angiotensin II	24310(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY inhibitors|nsubj|Effect inhibitors|nmod|END_ENTITY	Effect of ACE inhibitors on angiotensin_II in rat mesangial cells cultured in high glucose .
17676311	0	ACE	91,94	angiotensin_II	50,64	ACE	angiotensin II	1636	183	Gene	Gene	therapy|compound|START_ENTITY angiotensin_I|nmod|therapy angiotensin_I|nmod|conversion conversion|amod|END_ENTITY	Gradual reactivation of vascular angiotensin_I to angiotensin_II conversion during chronic ACE inhibitor therapy in patients with diabetes_mellitus .
17959639	0	ACE	0,3	angiotensin_II	56,70	ACE	angiotensin II	24310(Tax:10116)	24179(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|lung_injury lung_injury|nmod|rats rats|nmod|END_ENTITY	ACE mediates ventilator-induced lung_injury in rats via angiotensin_II but not bradykinin .
19463120	0	ACE	17,20	angiotensin_II	22,36	ACE	angiotensin II	1636	183	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	-LSB- Polymorphism of ACE , angiotensin_II , NO-synthase , estrogen_receptor genes and gender differences in their effects on development of cardiovascular_pathology -RSB- .
20634797	0	ACE	11,14	angiotensin_II	37,51	ACE	angiotensin II	1636	183	Gene	Gene	Effects|nmod|START_ENTITY inhibitors|nsubj|Effects inhibitors|nmod|END_ENTITY	Effects of ACE inhibitors on cardiac angiotensin_II and aldosterone in humans : `` Relevance of lipophilicity and affinity for ACE '' .
21546583	0	ACE	162,165	angiotensin_II	89,103	ACE	angiotensin II	1636	183	Gene	Gene	activity|appos|START_ENTITY angiotensin_I|dep|activity angiotensin_I|nmod|END_ENTITY	Carboxypeptidase activity common to viridans group streptococci cleaves angiotensin_I to angiotensin_II : an activity homologous to angiotensin-converting_enzyme -LRB- ACE -RRB- .
21622682	0	ACE	17,20	angiotensin_II	57,71	ACE	angiotensin II	11421(Tax:10090)	11606(Tax:10090)	Gene	Gene	Contributions|nmod|START_ENTITY chymase|nsubj|Contributions chymase|xcomp|endogenous endogenous|dobj|generation generation|amod|END_ENTITY	Contributions of ACE and mast cell chymase to endogenous angiotensin_II generation and leucocyte recruitment in vivo .
26937347	0	ACE	72,75	angiotensin_II	96,110	ACE	angiotensin II	1636	183	Gene	Gene	I/D|compound|START_ENTITY correspondence|nmod|I/D perfusion|nmod|correspondence modulates|acl|perfusion modulated|nsubj|modulates modulated|dobj|levels levels|compound|END_ENTITY	Exercise intensity modulates capillary perfusion in correspondence with ACE I/D modulated serum angiotensin_II levels .
8026000	0	ACE	99,102	angiotensin_II	18,32	ACE	angiotensin II	1636	183	Gene	Gene	inhibition|compound|START_ENTITY furosemide|nmod|inhibition suppression|xcomp|furosemide suppression|nsubj|Effect Effect|nmod|END_ENTITY	Effect of intense angiotensin_II suppression on the diuretic response to furosemide during chronic ACE inhibition .
8521580	0	ACE	11,14	angiotensin_II	56,70	ACE	angiotensin II	24310(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY inhibitors|nsubj|Effects inhibitors|advcl|circulating circulating|nmod|END_ENTITY	Effects of ACE inhibitors on circulating versus cardiac angiotensin_II in volume_overload-induced cardiac_hypertrophy in rats .
8569988	0	ACE	31,34	angiotensin_II	51,65	ACE	angiotensin II	1636	183	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphisms , angiotensin_II , ACE inhibitors and glomerulosclerosis -- a hypothesis .
8569988	0	ACE	67,70	angiotensin_II	51,65	ACE	angiotensin II	1636	183	Gene	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphisms , angiotensin_II , ACE inhibitors and glomerulosclerosis -- a hypothesis .
8583482	0	ACE	0,3	angiotensin_II	16,30	ACE	angiotensin II	1636	183	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|xcomp|antagonists antagonists|nsubj|END_ENTITY	ACE inhibitors , angiotensin_II antagonists and cough .
9249242	0	ACE	98,101	angiotensin_II	20,34	ACE	angiotensin II	1636	183	Gene	Gene	inhibitors|nmod|START_ENTITY isolated|nmod|inhibitors isolated|nsubj|Characterization Characterization|nmod|formation formation|amod|END_ENTITY	Characterization of angiotensin_II formation in human isolated bladder by selective inhibitors of ACE and human chymase : a functional and biochemical study .
9314414	0	ACE	94,97	angiotensin_II	6,20	ACE	angiotensin II	24310(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY effect|nmod|inhibition regulation|dep|effect regulation|amod|END_ENTITY	Renal angiotensin_II receptor regulation in two-kidney , one clip hypertensive rats : effect of ACE inhibition .
9723827	0	ACE	110,113	angiotensin_II	26,40	ACE	angiotensin II	1636	183	Gene	Gene	inhibitor|compound|START_ENTITY losartan|nmod|inhibitor losartan|nsubj|Start Start|nmod|therapy therapy|nmod|antagonist antagonist|amod|END_ENTITY	Start of therapy with the angiotensin_II antagonist losartan after immediate switch from pretreatment with an ACE inhibitor .
9793599	0	ACE	0,3	angiotensin_II	22,36	ACE	angiotensin II	1636	183	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|dep|cough cough|amod|END_ENTITY	ACE inhibitor - versus angiotensin_II blocker-induced cough and angioedema .
10085710	0	ACE	197,200	angiotensin_I_converting_enzyme	165,196	ACE	angiotensin I converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Lack of relationship between angiotensinogen gene m235t polymorphism and gene insertion/deletion -LRB- I/D-intron 16 -RRB- and Pst I RFLP -LRB- P/M-intron 7 -RRB- polymorphisms of the angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene and the development of H-gestosis .
15883972	0	ACE	116,119	angiotensin_I_converting_enzyme	83,114	ACE	angiotensin I converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Domain-selective ligand-binding modes and atomic level pharmacophore refinement in angiotensin_I_converting_enzyme -LRB- ACE -RRB- inhibitors .
16496609	0	ACE	75,78	angiotensin_I_converting_enzyme	42,73	ACE	angiotensin I converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The influence of I/D polymorphism of the angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene and 4G/5G polymorphism of plasminogen activator inhibitor -LRB- PAI-1 -RRB- gene promoter on the haemostatic system in patients with essential hypertension and dyslipidemia -RSB- .
21928698	0	ACE	56,59	angiotensin_I_converting_enzyme	23,54	ACE	angiotensin I converting enzyme	1636	1636	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	No association between angiotensin_I_converting_enzyme -LRB- ACE -RRB- I/D polymorphism and gastric_cancer risk among Japanese .
2829599	0	ACE	44,47	angiotensin_I_converting_enzyme	11,42	ACE	angiotensin I converting enzyme	1636	1636	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_I_converting_enzyme -LRB- ACE -RRB- related substances upon the vascular prostacyclin generation .
7696999	0	ACE	77,80	angiotensin_I_converting_enzyme	44,75	ACE	angiotensin I converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequencies of the angiotensinogen gene and angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene polymorphisms in African Americans .
8795663	0	ACE	62,65	angiotensin_I_converting_enzyme	29,60	ACE	angiotensin I converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion polymorphism in the angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene as a genetic risk factor for sarcoidosis .
10544843	0	ACE	123,126	angiotensin_converting_enzyme	92,121	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between systemic_lupus_erythematosus and insertion/deletion polymorphism of the angiotensin_converting_enzyme -LRB- ACE -RRB- gene .
10624863	0	ACE	70,73	angiotensin_converting_enzyme	39,68	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Screening of Zulu medicinal plants for angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
10682664	0	ACE	92,95	angiotensin_converting_enzyme	61,90	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the insertion/deletion polymorphism of the human angiotensin_converting_enzyme -LRB- ACE -RRB- gene in patients with renal_cancer .
10868493	0	ACE	44,47	angiotensin_converting_enzyme	13,42	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of angiotensin_converting_enzyme -LRB- ACE -RRB- genotype on interpretation of diagnostic tests for serum ACE activity .
10874368	0	ACE	46,49	angiotensin_converting_enzyme	15,44	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of angiotensin_converting_enzyme -LRB- ACE -RRB- gene polymorphism with hypertension in a Bangladeshi population .
10976394	0	ACE	47,50	angiotensin_converting_enzyme	16,45	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Proteinuria and angiotensin_converting_enzyme -LRB- ACE -RRB- gene polymorphism .
10983838	0	ACE	125,128	angiotensin_converting_enzyme	94,123	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Poor regression of myocardial_hypertrophy following concomitant chronic alcohol ingestion and angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition .
11806030	0	ACE	48,51	angiotensin_converting_enzyme	17,46	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	-LSB- Significance of angiotensin_converting_enzyme -LRB- ACE -RRB- in coronary circulation -RSB- .
12477155	0	ACE	85,88	angiotensin_converting_enzyme	54,83	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Therapeutic controversies in hypertension management : angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors or angiotensin receptor blockers for diabetic_nephropathy ?
12767053	0	ACE	66,69	angiotensin_converting_enzyme	35,64	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Modulation of metabolic control by angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition .
12803241	0	ACE	31,34	angiotensin_converting_enzyme	36,65	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	immunoreactivity|nmod|START_ENTITY immunoreactivity|appos|END_ENTITY	The higher immunoreactivity to ACE -LRB- angiotensin_converting_enzyme -RRB- in patients with type_2_diabetes_mellitus than in non-diabetic individuals .
14675780	0	ACE	45,48	angiotensin_converting_enzyme	14,43	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of angiotensin_converting_enzyme -LRB- ACE -RRB- activity by flavan-3-ols and procyanidins .
1536695	0	ACE	50,53	angiotensin_converting_enzyme	19,48	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Adverse effects of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
15724789	0	ACE	85,88	angiotensin_converting_enzyme	54,83	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Therapeutic controversies in hypertension management : angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors or angiotensin receptor blockers in diabetic_nephropathy ?
16901062	0	ACE	43,46	angiotensin_converting_enzyme	12,41	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- The use of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors during pregnancy clearly increases the risk of congenital_malformations -RSB- .
17123697	0	ACE	91,94	angiotensin_converting_enzyme	60,89	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The influence of mode of delivery and ACE genotype on serum angiotensin_converting_enzyme -LRB- ACE -RRB- activity in the mother and infant at term .
17163998	0	ACE	108,111	angiotensin_converting_enzyme	77,106	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of significant association of an insertion/deletion polymorphism in the angiotensin_converting_enzyme -LRB- ACE -RRB- gene with tropical_calcific_pancreatitis .
17520798	0	ACE	50,53	angiotensin_converting_enzyme	19,48	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association of angiotensin_converting_enzyme -LRB- ACE -RRB- polymorphisms with sleep_apnea and hypertension .
17875387	0	ACE	60,63	angiotensin_converting_enzyme	29,58	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Garlic extract reduces serum angiotensin_converting_enzyme -LRB- ACE -RRB- activity in nondiabetic and streptozotocin-diabetic rats .
18036585	0	ACE	57,60	angiotensin_converting_enzyme	26,55	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Therapeutic resistance to angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition is related to pharmacodynamic and - kinetic factors in 5/6 nephrectomized rats .
18843651	0	ACE	67,70	angiotensin_converting_enzyme	36,65	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Blood pressure lowering efficacy of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors for primary hypertension .
21688035	0	ACE	57,60	angiotensin_converting_enzyme	26,55	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Individualised therapy of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors in stable coronary_artery_disease : overview of the primary results of the PERindopril GENEtic association -LRB- PERGENE -RRB- study .
21782455	0	ACE	136,139	angiotensin_converting_enzyme	105,134	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
21939743	0	ACE	46,49	angiotensin_converting_enzyme	15,44	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of angiotensin_converting_enzyme -LRB- ACE -RRB- gene I/D polymorphism and polycystic_ovary_syndrome -LRB- PCOS -RRB- .
2199299	0	ACE	76,79	angiotensin_converting_enzyme	45,74	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Does kinin mediate the hypotensive action of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors ?
22808171	0	ACE	63,66	angiotensin_converting_enzyme	32,61	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA methylation analysis of the angiotensin_converting_enzyme -LRB- ACE -RRB- gene in major_depression .
23000565	0	ACE	46,49	angiotensin_converting_enzyme	15,44	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of angiotensin_converting_enzyme -LRB- ACE -RRB- gene I/D polymorphism and rheumatoid_arthritis .
23183619	0	ACE	115,118	angiotensin_converting_enzyme	84,113	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Attenuation of focal cerebral ischemic_injury following post-ischemic inhibition of angiotensin_converting_enzyme -LRB- ACE -RRB- activity in normotensive rat .
23409414	0	ACE	57,60	angiotensin_converting_enzyme	26,55	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hypertension subtypes and angiotensin_converting_enzyme -LRB- ACE -RRB- gene polymorphism in Indian population .
23743058	0	ACE	149,152	angiotensin_converting_enzyme	118,147	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Isolation , identification and molecular docking studies of a new isolated compound , from Onopordon_acanthium : a novel angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor .
23777825	0	ACE	135,138	angiotensin_converting_enzyme	104,133	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5 ,11 - dione analogues as potent angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
2382917	0	ACE	106,109	angiotensin_converting_enzyme	75,104	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Outcome of renal_crisis in systemic_sclerosis : relation to availability of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
2402813	0	ACE	73,76	angiotensin_converting_enzyme	42,71	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	-LSB- Side effects in 28 patients treated with angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor in arterial hypertension in general practice -RSB- .
2422495	0	ACE	45,48	angiotensin_converting_enzyme	14,43	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of angiotensin_converting_enzyme -LRB- ACE -RRB- in the pharmacokinetics and pharmacodynamics of ACE inhibitors .
24691160	0	ACE	113,116	angiotensin_converting_enzyme	82,111	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	New perspectives in the renin-angiotensin-aldosterone system -LRB- RAAS -RRB- I : endogenous angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition .
25300819	0	ACE	131,134	angiotensin_converting_enzyme	100,129	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and evaluation of novel triazoles and mannich bases functionalized 1,4-dihydropyridine as angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
25332829	0	ACE	48,51	angiotensin_converting_enzyme	17,46	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A pilot study of angiotensin_converting_enzyme -LRB- ACE -RRB- genotype and return of spontaneous circulation following out-of-hospital cardiac_arrest .
25603633	0	ACE	65,68	angiotensin_converting_enzyme	34,63	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Small_bowel_angioedema induced by angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor : US and CT findings .
2829597	0	ACE	42,45	angiotensin_converting_enzyme	11,40	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Changes of angiotensin_converting_enzyme -LRB- ACE -RRB- levels during activation of the renin-angiotensin-aldosterone system -LRB- RAAs -RRB- .
2838262	0	ACE	51,54	angiotensin_converting_enzyme	20,49	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of angiotensin_converting_enzyme -LRB- ACE -RRB- in the testis and assessment of the in vivo effects of the ACE inhibitor perindopril .
3033786	0	ACE	49,52	angiotensin_converting_enzyme	18,47	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of the angiotensin_converting_enzyme -LRB- ACE -RRB- in cultures of rat peritoneal macrophages .
3034521	0	ACE	55,58	angiotensin_converting_enzyme	24,53	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Circadian rhythm of the angiotensin_converting_enzyme -LRB- ACE -RRB- activity in serum of healthy adult subjects .
6182819	0	ACE	80,83	angiotensin_converting_enzyme	49,78	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Characteristics , assay and semeiologic value of angiotensin_converting_enzyme -LRB- ACE -RRB- -RSB- .
8448584	0	ACE	57,60	angiotensin_converting_enzyme	26,55	ACE	angiotensin converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Dose-dependent effects of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors on glomerular prostanoid production by normotensive rats .
8677193	0	ACE	44,47	angiotensin_converting_enzyme	13,42	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	-LSB- Analysis of angiotensin_converting_enzyme -LRB- ACE -RRB- polymorphism in patients with myocardial_infarction in the Polish population -RSB- .
9222960	0	ACE	131,134	angiotensin_converting_enzyme	100,129	ACE	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Congenital renal_tubular_dysplasia and skull ossification defects similar to teratogenic effects of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
9246391	0	ACE	43,46	angiotensin_converting_enzyme	12,41	ACE	angiotensin converting enzyme	613133(Tax:9823)	613133(Tax:9823)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Presence of angiotensin_converting_enzyme -LRB- ACE -RRB- activity in serum of amphibian : comparison with ACE activity of mammalian serum .
9447482	0	ACE	95,98	angiotensin_converting_enzyme	64,93	ACE	angiotensin converting enzyme	610668(Tax:9615)	610668(Tax:9615)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Treatment of X-linked_hereditary_nephritis in Samoyed dogs with angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor .
19162259	0	ACE	31,34	angiotensinogen	37,52	ACE	angiotensinogen	1636	183	Gene	Gene	enzyme|appos|START_ENTITY enzyme|appos|END_ENTITY	Angiotensin-converting enzyme -LRB- ACE -RRB- , angiotensinogen -LRB- AGT -RRB- , and angiotensin_II_type_1_receptor -LRB- AT1R -RRB- gene polymorphisms in generalized aggressive periodontitis .
8394952	0	ACE	10,13	atrial_natriuretic_factor	28,53	ACE	atrial natriuretic factor	24310(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY inhibitors|nsubj|Effect inhibitors|nmod|END_ENTITY	Effect of ACE inhibitors on atrial_natriuretic_factor in the brains of rats with reduced renal mass .
19463120	0	ACE	17,20	estrogen_receptor	51,68	ACE	estrogen receptor	1636	2099	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	-LSB- Polymorphism of ACE , angiotensin_II , NO-synthase , estrogen_receptor genes and gender differences in their effects on development of cardiovascular_pathology -RSB- .
27050505	0	ACE-1	38,43	angiotensin-converting_enzyme-1	5,36	ACE-1	angiotensin-converting enzyme-1	1636	1636	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Does angiotensin-converting_enzyme-1 -LRB- ACE-1 -RRB- gene polymorphism lead to chronic kidney_disease among hypertensive patients ?
15231706	0	ACE2	55,59	ACE	41,44	ACE2	ACE	302668(Tax:10116)	24310(Tax:10116)	Gene	Gene	homolog|appos|START_ENTITY homolog|appos|END_ENTITY	The novel angiotensin-converting enzyme -LRB- ACE -RRB- homolog , ACE2 , is selectively expressed by adult Leydig cells of the testis .
17303661	0	ACE2	147,151	ACE	140,143	ACE2	ACE	59272	1636	Gene	Gene	ratio|compound|START_ENTITY expression|nmod|ratio expression|nmod|hypertension hypertension|nmod|END_ENTITY	Synergistic expression of angiotensin-converting_enzyme -LRB- ACE -RRB- and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio .
17303661	0	ACE2	147,151	ACE	57,60	ACE2	ACE	59272	1636	Gene	Gene	ratio|compound|START_ENTITY expression|nmod|ratio expression|nmod|angiotensin-converting_enzyme angiotensin-converting_enzyme|appos|END_ENTITY	Synergistic expression of angiotensin-converting_enzyme -LRB- ACE -RRB- and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio .
17579661	0	ACE2	0,4	ACE	72,75	ACE2	ACE	70008(Tax:10090)	11421(Tax:10090)	Gene	Gene	inhibition|nsubj|START_ENTITY inhibition|nmod|expression expression|compound|END_ENTITY	ACE2 inhibition worsens_glomerular_injury in association with increased ACE expression in streptozotocin-induced diabetic mice .
18192334	0	ACE2	73,77	ACE	85,88	ACE2	ACE	302668(Tax:10116)	24310(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Differential regulation of renal angiotensin-converting enzyme -LRB- ACE -RRB- and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats .
19698082	0	ACE2	19,23	ACE	87,90	ACE2	ACE	302668(Tax:10116)	24310(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Reduction|nmod|expression ameliorated|nsubjpass|Reduction ameliorated|nmod|inhibition inhibition|compound|END_ENTITY	Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition .
22800722	0	ACE2	60,64	ACE	54,57	ACE2	ACE	59272	1636	Gene	Gene	angiotensin-I-converting_enzyme|appos|START_ENTITY angiotensin-I-converting_enzyme|appos|END_ENTITY	Three key proteases -- angiotensin-I-converting_enzyme -LRB- ACE -RRB- , ACE2 and renin -- within and beyond the renin-angiotensin system .
26016560	0	ACE2	64,68	ACE	27,30	ACE2	ACE	302668(Tax:10116)	24310(Tax:10116)	Gene	Gene	peptide|ccomp|START_ENTITY peptide|nsubj|END_ENTITY	Egg ovotransferrin-derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats .
27062780	0	ACE2	55,59	Angiotensin_Converting_Enzyme_2	22,53	ACE2	Angiotensin Converting Enzyme 2	302668(Tax:10116)	302668(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Protective Effect of Angiotensin_Converting_Enzyme_2 -LRB- ACE2 -RRB- Against Chronic Intermittent Hypoxia-induced Pulmonary_Oxidative_Stress_Injury in Rats -RSB- .
19224387	0	ACE2	33,37	Angiotensin_converting_enzyme_2	0,31	ACE2	Angiotensin converting enzyme 2	59272	59272	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Angiotensin_converting_enzyme_2 -LRB- ACE2 -RRB- activity in fetal calf serum : implications for cell culture research .
24177423	0	ACE2	34,38	Apelin	0,6	ACE2	Apelin	70008(Tax:10090)	30878(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Apelin is a positive regulator of ACE2 in failing hearts .
25001410	0	ACE2	24,28	Efg1	0,4	ACE2	Efg1	850822(Tax:4932)	853188(Tax:4932)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida_albicans morphogenesis .
26196539	0	ACE2	58,62	GLP-1_Receptor	18,32	ACE2	GLP-1 Receptor	302668(Tax:10116)	25051(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	Activation of the GLP-1_Receptor by Liraglutide Increases ACE2 Expression , Reversing Right Ventricle Hypertrophy , and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats .
26067610	0	ACE2	8,12	L-FABP	40,46	ACE2	L-FABP	59272	2168	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Urinary ACE2 is associated with urinary L-FABP and albuminuria in patients with chronic_kidney_disease .
24147777	0	ACE2	58,62	SIRT1	67,72	ACE2	SIRT1	59272	23411	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- by SIRT1 under conditions of cell energy stress .
12358520	0	ACE2	101,105	angiotensin-converting_enzyme-related_carboxypeptidase	45,99	ACE2	angiotensin-converting enzyme-related carboxypeptidase	59272	59272	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Substrate-based design of the first class of angiotensin-converting_enzyme-related_carboxypeptidase -LRB- ACE2 -RRB- inhibitors .
15693124	0	ACE2	103,107	angiotensin-converting_enzyme_2	70,101	ACE2	angiotensin-converting enzyme 2	70008(Tax:10090)	70008(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Cloning , expression and sequence analysis and tissue distribution of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- gene in adult mice -RSB- .
21864606	0	ACE2	78,82	angiotensin-converting_enzyme_2	45,76	ACE2	angiotensin-converting enzyme 2	59272	59272	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Identifying the regulatory element for human angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- expression in human cardiofibroblasts .
24147777	0	ACE2	58,62	angiotensin-converting_enzyme_2	25,56	ACE2	angiotensin-converting enzyme 2	59272	59272	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- by SIRT1 under conditions of cell energy stress .
24329564	0	ACE2	41,45	angiotensin-converting_enzyme_2	8,39	ACE2	angiotensin-converting enzyme 2	59272	59272	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- in diabetic_cardiovascular_complications .
16822235	0	ACE2	21,25	angiotensin_I-converting_enzyme_2	27,60	ACE2	angiotensin I-converting enzyme 2	59272	59272	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Association study of ACE2 -LRB- angiotensin_I-converting_enzyme_2 -RRB- gene polymorphisms with coronary_heart_disease and myocardial_infarction in a Chinese Han population .
11718896	0	ACF	103,106	apobec-1_complementation_factor	70,101	ACF	apobec-1 complementation factor	29974	29974	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation , characterization and developmental regulation of the human apobec-1_complementation_factor -LRB- ACF -RRB- gene .
8932379	0	ACH-2	69,74	NF-kappaB	56,65	ACH-2	NF-kappaB	641371	4790	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells .
25862630	0	ACHN	97,101	Akt1	51,55	ACHN	Akt1	55323	207	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Enhanced sensitivity to sorafenib by inhibition of Akt1 expression in human renal_cell_carcinoma ACHN cells both in vitro and in vivo .
16201286	0	ACHN	76,80	MRP1	68,72	ACHN	MRP1	55323	4363	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of trastuzumab in combination with IFN alpha-2b on HER2 and - MRP1 of ACHN .
26452058	0	ACLY	0,4	ETV4	63,67	ACLY	ETV4	47	2118	Gene	Gene	Regulate|nsubj|START_ENTITY Regulate|nmod|END_ENTITY	ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via a-ketoglutarate .
9630632	0	ACO2	60,64	mitochondrial_aconitase	30,53	ACO2	mitochondrial aconitase	50	50	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the human mitochondrial_aconitase gene -LRB- ACO2 -RRB- .
12409270	0	ACP1	37,41	acid_phosphatase	19,35	ACP1	acid phosphatase	52	52	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the acid_phosphatase -LRB- ACP1 -RRB- gene with triglyceride levels in obese women .
23604121	0	ACP5	0,4	FoxM1	41,46	ACP5	FoxM1	54	2305	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	ACP5 , a direct transcriptional target of FoxM1 , promotes tumor metastasis and indicates poor prognosis in hepatocellular_carcinoma .
7587387	0	ACP5	36,40	uteroferrin	18,29	ACP5	uteroferrin	397414(Tax:9823)	397414(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the uteroferrin gene -LRB- ACP5 -RRB- to swine chromosome 2q12 -- > q21 by fluorescence in situ hybridization .
9427394	0	ACS1	65,69	CAT8	98,102	ACS1	CAT8	851245(Tax:4932)	855323(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Transcriptional control of the yeast acetyl-CoA synthetase gene , ACS1 , by the positive regulators CAT8 and ADR1 and the pleiotropic repressor UME6 .
24462768	0	ACSL1	124,129	acyl-CoA_synthetase_long-chain_family_member_1	76,122	ACSL1	acyl-CoA synthetase long-chain family member 1	2180	2180	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA_synthetase_long-chain_family_member_1 -LRB- ACSL1 -RRB- mRNA .
17453651	0	ACSL1	89,94	acyl_coenzyme_A_synthetase_long-chain_1	48,87	ACSL1	acyl coenzyme A synthetase long-chain 1	448982(Tax:9823)	448982(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Nucleotide sequence and polymorphism of the pig acyl_coenzyme_A_synthetase_long-chain_1 -LRB- ACSL1 -RRB- gene .
21903867	0	ACSL4	74,79	SHP2	21,25	ACSL4	SHP2	2182	5781	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4 .
16137793	0	ACT	26,29	Alpha-1-antichymotrypsin	0,24	ACT	Alpha-1-antichymotrypsin	12	12	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Alpha-1-antichymotrypsin -LRB- ACT or SERPINA3 -RRB- polymorphism may affect age-at-onset and disease duration of Alzheimer 's _ disease .
9218799	0	ACT2	37,41	actin	25,30	ACT2	actin	851532(Tax:4932)	850504(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A role for the divergent actin gene , ACT2 , in nuclear pore structure and function .
8754679	0	ACT7	16,20	actin	21,26	ACT7	actin	830841(Tax:3702)	823805(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli .
15111311	0	ACTB	72,76	beta-actin	55,65	ACTB	beta-actin	60	728378	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Activation of the GLI oncogene through fusion with the beta-actin gene -LRB- ACTB -RRB- in a group of distinctive pericytic neoplasms : pericytoma with t -LRB- 7 ; 12 -RRB- .
17434848	0	ACTG	84,88	LDL-C	49,54	ACTG	LDL-C	71	22796	Gene	Gene	Comparison|dep|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of direct and indirect measurement of LDL-C in HIV-infected individuals : ACTG 5087 .
7588377	0	ACTH	54,58	ACTH_receptor	14,27	ACTH	ACTH receptor	5443	4158	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Regulation of ACTH_receptor mRNA and binding sites by ACTH and angiotensin_II in cultured human and bovine adrenal_fasciculata cells .
2999733	0	ACTH	33,37	CCK	13,16	ACTH	CCK	403659(Tax:9615)	609547(Tax:9615)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of CCK and bombesin on ACTH and cortisol secretion in the conscious dog .
11589148	0	ACTH	108,112	CRF	38,41	ACTH	CRF	5443	1392	Gene	Gene	secretion|compound|START_ENTITY control|nmod|secretion implications|nmod|control expression|dep|implications expression|nmod|END_ENTITY	Hypothalamic and limbic expression of CRF and vasopressin during lactation : implications for the control of ACTH secretion and stress hyporesponsiveness .
2830315	1	ACTH	197,201	CRF	125,128	ACTH	CRF	5443	1392	Gene	Gene	rhythm|nmod|START_ENTITY mediation|nmod|rhythm evidence|nmod|mediation provides|dobj|evidence provides|nmod|bioassay bioassay|nmod|corticotropin-releasing_factor corticotropin-releasing_factor|appos|END_ENTITY	In vivo bioassay of corticotropin-releasing_factor -LRB- CRF -RRB- which provides evidence for CRF mediation of the diurnal rhythm of ACTH .
2830315	1	ACTH	197,201	CRF	158,161	ACTH	CRF	5443	1392	Gene	Gene	rhythm|nmod|START_ENTITY mediation|nmod|rhythm mediation|compound|END_ENTITY	In vivo bioassay of corticotropin-releasing_factor -LRB- CRF -RRB- which provides evidence for CRF mediation of the diurnal rhythm of ACTH .
3001563	0	ACTH	81,85	CRF	75,78	ACTH	CRF	5443	1392	Gene	Gene	application|dep|START_ENTITY application|nmod|corticotropin_releasing_factor corticotropin_releasing_factor|appos|END_ENTITY	Intravenous application of ovine and human corticotropin_releasing_factor -LRB- CRF -RRB- : ACTH , cortisol and CRF levels .
3008569	0	ACTH	45,49	CRF	24,27	ACTH	CRF	5443	1392	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	By 95 days of gestation CRF increases plasma ACTH and cortisol in ovine fetuses .
3019060	0	ACTH	23,27	CRF	0,3	ACTH	CRF	5443	1392	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	CRF : its regulation of ACTH and pro-opiomelanocortin peptide release and its extra hypothalamic occurrence .
3019743	0	ACTH	70,74	CRF	38,41	ACTH	CRF	5443	1392	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolonged administration of CRF on plasma concentrations of ACTH in patients with Addison 's _ disease .
35343	1	ACTH	106,110	CRF	175,178	ACTH	CRF	5443	1392	Gene	Gene	release|compound|START_ENTITY peptides|nmod|release Effect|nmod|peptides induced|nsubj|Effect induced|nmod|corticotropin_releasing_factor corticotropin_releasing_factor|appos|END_ENTITY	Effect of neurogenic peptides and neurotransmitter substances on ACTH release induced by hypothalamic corticotropin_releasing_factor -LRB- CRF -RRB- .
6323156	0	ACTH	74,78	CRF	59,62	ACTH	CRF	5443	1392	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of synthetic ovine corticotropin-releasing_factor -LRB- CRF -RRB- on plasma ACTH and cortisol in 31 normal human males .
2852510	0	ACTH	12,16	CRH	35,38	ACTH	CRH	5443	1392	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment .
15626289	0	ACTH	48,52	adrenocorticotropic_hormone	19,46	ACTH	adrenocorticotropic hormone	5443	5443	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Value of assessing adrenocorticotropic_hormone -LRB- ACTH -RRB- levels in differential diagnosis of hypercorticism .
18128849	0	ACTH	77,81	adrenocorticotropic_hormone	48,75	ACTH	adrenocorticotropic hormone	5443	5443	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The metabolic and clinical effects of pituitary adrenocorticotropic_hormone -LRB- ACTH -RRB- in spontaneous hypoglycemosis .
6315546	0	ACTH	6,10	beta-lipotropin	12,27	ACTH	beta-lipotropin	5443	5443	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Human ACTH , beta-lipotropin and beta-endorphin levels in maternal plasma at delivery .
232792	0	ACTH	11,15	corticotropin-releasing_factor	29,59	ACTH	corticotropin-releasing factor	5443	1392	Gene	Gene	Control|nmod|START_ENTITY secretion|nsubj|Control secretion|nmod|END_ENTITY	Control of ACTH secretion by corticotropin-releasing_factor -LRB- s -RRB- .
2830315	1	ACTH	197,201	corticotropin-releasing_factor	93,123	ACTH	corticotropin-releasing factor	5443	1392	Gene	Gene	rhythm|nmod|START_ENTITY mediation|nmod|rhythm evidence|nmod|mediation provides|dobj|evidence provides|nmod|bioassay bioassay|nmod|END_ENTITY	In vivo bioassay of corticotropin-releasing_factor -LRB- CRF -RRB- which provides evidence for CRF mediation of the diurnal rhythm of ACTH .
3039377	0	ACTH	34,38	corticotropin-releasing_factor	52,82	ACTH	corticotropin-releasing factor	5443	1392	Gene	Gene	stimulation|nmod|START_ENTITY Evidence|nmod|stimulation secretion|nsubj|Evidence secretion|nmod|END_ENTITY	Evidence for local stimulation of ACTH secretion by corticotropin-releasing_factor in human placenta .
4364642	0	ACTH	13,17	corticotropin-releasing_factor	83,113	ACTH	corticotropin-releasing factor	5443	1392	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|dep|kinetics kinetics|nmod|stimulation stimulation|nmod|END_ENTITY	Secretion of ACTH by isolated anterior pituitary cells : kinetics of stimulation of corticotropin-releasing_factor and of inhibition by corticosterone .
6323156	0	ACTH	74,78	corticotropin-releasing_factor	27,57	ACTH	corticotropin-releasing factor	5443	1392	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of synthetic ovine corticotropin-releasing_factor -LRB- CRF -RRB- on plasma ACTH and cortisol in 31 normal human males .
2840977	0	ACTH	12,16	corticotropin-releasing_hormone	39,70	ACTH	corticotropin-releasing hormone	5443	1392	Gene	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of ACTH and cortisol to human corticotropin-releasing_hormone after short-term abstention from alcohol_abuse .
9094448	0	ACTH	37,41	interleukin-1beta	54,71	ACTH	interleukin-1beta	5443	24494(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Effects of gender and gonadectomy on ACTH response to interleukin-1beta in the rat : comparison with the modulation of ACTH response to immobilization stress .
6274571	0	ACTH	0,4	renin_and_angiotensin_II	23,47	ACTH	renin and angiotensin II	5443	5972;183	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	ACTH stimulates plasma renin_and_angiotensin_II in man .
12051514	0	ACTH-R	135,141	ACTH_receptor	120,133	ACTH-R	ACTH receptor	443482(Tax:9940)	443482(Tax:9940)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Adrenocorticotrophic hormone -LRB- ACTH -RRB- stimulation of sheep fetal adrenal cortex can occur without increased expression of ACTH_receptor -LRB- ACTH-R -RRB- mRNA .
7608277	0	ACTH-R	54,60	adrenocorticotropin_receptor	24,52	ACTH-R	adrenocorticotropin receptor	4158	4158	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel mutation of the adrenocorticotropin_receptor -LRB- ACTH-R -RRB- gene in a family with the syndrome of isolated_glucocorticoid_deficiency , but no ACTH-R abnormalities in two families with the triple_A_syndrome .
7588377	0	ACTH_receptor	14,27	ACTH	54,58	ACTH receptor	ACTH	4158	5443	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Regulation of ACTH_receptor mRNA and binding sites by ACTH and angiotensin_II in cultured human and bovine adrenal_fasciculata cells .
12051514	0	ACTH_receptor	120,133	ACTH-R	135,141	ACTH receptor	ACTH-R	443482(Tax:9940)	443482(Tax:9940)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Adrenocorticotrophic hormone -LRB- ACTH -RRB- stimulation of sheep fetal adrenal cortex can occur without increased expression of ACTH_receptor -LRB- ACTH-R -RRB- mRNA .
9888512	0	ACTH_receptor	53,66	SF-1	0,4	ACTH receptor	SF-1	4158	7536	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	SF-1 and the transcriptional regulation of the human ACTH_receptor gene .
26127003	0	ACTL9	40,45	KIF3A	15,20	ACTL9	KIF3A	284382	11127	Gene	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of KIF3A and OVOL1 , but not ACTL9 , with atopic_dermatitis in Chinese pediatric patients .
26127003	0	ACTL9	40,45	KIF3A	15,20	ACTL9	KIF3A	284382	11127	Gene	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of KIF3A and OVOL1 , but not ACTL9 , with atopic_dermatitis in Chinese pediatric patients .
12099693	0	ACTN1	44,49	alpha-actinin_1	27,42	ACTN1	alpha-actinin 1	81634(Tax:10116)	81634(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Brain-specific splicing of alpha-actinin_1 -LRB- ACTN1 -RRB- mRNA .
26288717	0	ACTN4	34,39	actinin-4	23,32	ACTN4	actinin-4	81	81	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The biological role of actinin-4 -LRB- ACTN4 -RRB- in malignant phenotypes of cancer .
10700177	0	ACTN4	13,18	alpha-actinin-4	29,44	ACTN4	alpha-actinin-4	81	81	Gene	Gene	Mutations|nmod|START_ENTITY Mutations|amod|END_ENTITY	Mutations in ACTN4 , encoding alpha-actinin-4 , cause familial focal segmental_glomerulosclerosis .
12615714	0	ACVR2	96,101	activin_A_type_II_receptor	68,94	ACVR2	activin A type II receptor	92	92	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence of selection for clones having genetic inactivation of the activin_A_type_II_receptor -LRB- ACVR2 -RRB- gene in gastrointestinal_cancers .
8995483	0	ACVR2	53,58	activin_receptor_type_II	22,46	ACVR2	activin receptor type II	281598(Tax:9913)	281598(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning of the bovine activin_receptor_type_II gene -LRB- ACVR2 -RRB- and mapping to chromosome 2 -LRB- BTA2 -RRB- .
20056902	0	ACVRL1	77,83	ALK1	85,89	ACVRL1	ALK1	94	94	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Clinical outcomes of pulmonary_arterial_hypertension in patients carrying an ACVRL1 -LRB- ALK1 -RRB- mutation .
25383314	0	AChE	22,26	Acetylcholinesterase	0,20	AChE	Acetylcholinesterase	11423(Tax:10090)	11423(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Acetylcholinesterase -LRB- AChE -RRB- inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver .
10212805	0	AChE	54,58	acetylcholinesterase	32,52	AChE	acetylcholinesterase	396388(Tax:9031)	396388(Tax:9031)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Ultrastructural localization of acetylcholinesterase -LRB- AChE -RRB- activity in the chicken Harderian gland .
115211	0	AChE	59,63	acetylcholinesterase	37,57	AChE	acetylcholinesterase	83817(Tax:10116)	83817(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Ultrastructural localization of the acetylcholinesterase -LRB- AChE -RRB- activity in the diaphragm of the rat embryo -LRB- author 's transl -RRB- -RSB- .
17158047	0	AChE	105,109	acetylcholinesterase	83,103	AChE	acetylcholinesterase	43	43	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Quantitative structure-activity relationship -LRB- QSAR -RRB- of tacrine derivatives against acetylcholinesterase -LRB- AChE -RRB- activity using variable selections .
17765967	0	AChE	48,52	acetylcholinesterase	26,46	AChE	acetylcholinesterase	43	43	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effect of azadirachtin on acetylcholinesterase -LRB- AChE -RRB- activity and histology of the brown_planthopper_Nilaparvata lugens -LRB- St l -RRB- .
2013059	0	AChE	49,53	acetylcholinesterase	27,47	AChE	acetylcholinesterase	43	43	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	A noncholinergic action of acetylcholinesterase -LRB- AChE -RRB- in the brain : from neuronal secretion to the generation of movement .
23863115	0	AChE	119,123	acetylcholinesterase	97,117	AChE	acetylcholinesterase	43	43	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Molecular dynamics simulation study and molecular docking descriptors in structure-based QSAR on acetylcholinesterase -LRB- AChE -RRB- inhibitors .
24589276	0	AChE	32,36	acetylcholinesterase	10,30	AChE	acetylcholinesterase	43	43	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of acetylcholinesterase -LRB- AChE -RRB- point-of-care testing in OP poisoning on knowledge , attitudes and practices of treating physicians in Sri Lanka .
25450939	0	AChE	44,48	acetylcholinesterase	22,42	AChE	acetylcholinesterase	43	43	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Circannual rhythms of acetylcholinesterase -LRB- AChE -RRB- activity in the freshwater fish Cnesterodon decemmaculatus .
3216102	0	AChE	50,54	acetylcholinesterase	28,48	AChE	acetylcholinesterase	100009390(Tax:9986)	100009390(Tax:9986)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Morphological changes after acetylcholinesterase -LRB- AChE -RRB- inhibition by dichlorvos -LRB- DDVP -RRB- in young rabbit brain .
8052513	0	AChE	71,75	acetylcholinesterase	49,69	AChE	acetylcholinesterase	101123006	101123006	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Purification and biochemical characterization of acetylcholinesterase -LRB- AChE -RRB- from the excretory/secretory products of Trichostrongylus colubriformis .
8545050	0	AChE	45,49	acetylcholinesterase	23,43	AChE	acetylcholinesterase	43	43	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inverse correlation of acetylcholinesterase -LRB- AChE -RRB- activity with the presence of neurofilament inclusions in dorsal root ganglion neurons cultured in the presence of a reversible inhibitor of AChE .
8994044	0	AChE	30,34	acetylcholinesterase	8,28	AChE	acetylcholinesterase	11423(Tax:10090)	11423(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Reduced acetylcholinesterase -LRB- AChE -RRB- activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient , but not TrkB-deficient , mice .
9500847	0	AChE	61,65	acetylcholinesterase	39,59	AChE	acetylcholinesterase	43	43	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Elucidation of biphasic alterations on acetylcholinesterase -LRB- AChE -RRB- activity and membrane fluidity in the structure-functional effects of tetracaine on AChE-associated membrane vesicles .
23380993	0	AD8	14,17	AD8	45,48	AD8	AD8	353128	353128	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	The informant AD8 is superior to participant AD8 in detecting cognitive_impairment in a memory clinic setting .
23380993	0	AD8	45,48	AD8	14,17	AD8	AD8	353128	353128	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	The informant AD8 is superior to participant AD8 in detecting cognitive_impairment in a memory clinic setting .
3985005	0	ADA	115,118	ADA	64,67	ADA	ADA	100	100	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Adenosine_deaminase -LRB- ADA -RRB- in leukemia : clinical value of plasma ADA activity and characterization of leukemic cell ADA .
3985005	0	ADA	64,67	ADA	115,118	ADA	ADA	100	100	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Adenosine_deaminase -LRB- ADA -RRB- in leukemia : clinical value of plasma ADA activity and characterization of leukemic cell ADA .
25861440	0	ADA	47,50	Adenosine_Deaminase	26,45	ADA	Adenosine Deaminase	100	100	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	Diagnostic Value of Serum Adenosine_Deaminase -LRB- ADA -RRB- Level for Pulmonary_Tuberculosis .
871426	0	ADA	21,24	Adenosine_deaminase	0,19	ADA	Adenosine deaminase	100	100	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Adenosine_deaminase -LRB- ADA -RRB- activity in lymphocytes of normal individuals and patients with chronic_lymphatic_leukaemia .
10200056	0	ADA	50,53	adenosine_deaminase	29,48	ADA	adenosine deaminase	100	100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Seven novel mutations in the adenosine_deaminase -LRB- ADA -RRB- gene in patients with severe and delayed onset combined_immunodeficiency : G74C , V129M , G140E , R149W , Q199P , 462delG , and E337del .
10853264	0	ADA	42,45	adenosine_deaminase	21,40	ADA	adenosine deaminase	11486(Tax:10090)	11486(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of murine adenosine_deaminase -LRB- ADA -RRB- in transgenic maize .
11860709	0	ADA	48,51	adenosine_deaminase	27,46	ADA	adenosine deaminase	100	100	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Flow cytometry analysis of adenosine_deaminase -LRB- ADA -RRB- expression : a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy .
17181544	0	ADA	69,72	adenosine_deaminase	48,67	ADA	adenosine deaminase	100	100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Carrier frequency of a nonsense mutation in the adenosine_deaminase -LRB- ADA -RRB- gene implies a high incidence of ADA-deficient severe_combined_immunodeficiency -LRB- SCID -RRB- in Somalia and a single , common haplotype indicates common ancestry .
17539288	0	ADA	43,46	adenosine_deaminase	22,41	ADA	adenosine deaminase	100	100	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Diagnostic utility of adenosine_deaminase -LRB- ADA -RRB- activity in pleural fluid and serum of tuberculous and non-tuberculous respiratory_disease patients .
2549545	0	ADA	78,81	adenosine_deaminase	57,76	ADA	adenosine deaminase	100	100	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Retroviral vector-mediated high-efficiency expression of adenosine_deaminase -LRB- ADA -RRB- in hematopoietic long-term cultures of ADA-deficient marrow cells .
2588953	0	ADA	37,40	adenosine_deaminase	16,35	ADA	adenosine deaminase	100	100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transfer of the adenosine_deaminase -LRB- ADA -RRB- gene of a B-lymphoblastoid cell line -LRB- LCL -RRB- to an ADA-deficient LCL by a microcell-mediated chromosome transfer technique .
26417242	0	ADA	35,38	adenosine_deaminase	14,33	ADA	adenosine deaminase	100	100	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of adenosine_deaminase -LRB- ADA -RRB- isoenzymes activity and tumor_necrosis_factor-a -LRB- TNFa -RRB- concentration in chronic heart_failure .
27017482	0	ADA	33,36	adenosine_deaminase	12,31	ADA	adenosine deaminase	100	100	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Can pleural adenosine_deaminase -LRB- ADA -RRB- levels in pleural_tuberculosis predict the presence of pulmonary_tuberculosis ?
3485513	0	ADA	84,87	adenosine_deaminase	58,77	ADA	adenosine deaminase	24165(Tax:10116)	24165(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosome_anomalies associated with amplification of the adenosine_deaminase gene -LRB- ADA -RRB- in rat hepatoma cells .
7655514	0	ADA	39,42	adenosine_deaminase	18,37	ADA	adenosine deaminase	100	100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disruption of the adenosine_deaminase -LRB- ADA -RRB- gene using a dicistronic promoterless construct : production of an ADA-deficient homozygote ES cell line .
8031011	0	ADA	60,63	adenosine_deaminase	39,58	ADA	adenosine deaminase	100	100	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	An Asp8Asn substitution results in the adenosine_deaminase -LRB- ADA -RRB- genetic polymorphism -LRB- ADA_2 allozyme -RRB- : occurrence on different chromosomal backgrounds and apparent intragenic crossover .
9475605	0	ADA	48,51	adenosine_deaminase	27,46	ADA	adenosine deaminase	100	100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Visible integration of the adenosine_deaminase -LRB- ADA -RRB- gene into the recipient genome after gene therapy .
9154821	0	ADA1	0,4	GCN5	74,78	ADA1	GCN5	117143	2648	Gene	Gene	has|nsubj|START_ENTITY has|dobj|effects effects|nmod|END_ENTITY	ADA1 , a novel component of the ADA/GCN5 complex , has broader effects than GCN5 , ADA2 , or ADA3 .
15670822	0	ADA2	0,4	adenosine_deaminase	16,35	ADA2	adenosine deaminase	51816	100	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	ADA2 isoform of adenosine_deaminase from pleural fluid .
12206153	0	ADA2	47,51	adenosine_deaminase_2	24,45	ADA2	adenosine deaminase 2	51816	51816	Gene	Gene	activity|compound|START_ENTITY activity|nummod|END_ENTITY	The usefulness of serum adenosine_deaminase_2 -LRB- ADA2 -RRB- activity in adults for the diagnosis of pulmonary_tuberculosis .
20413580	0	ADA3	6,10	RARalpha	21,29	ADA3	RARalpha	10474	5914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket .
15496419	0	ADA3	6,10	estrogen_receptor	20,37	ADA3	estrogen receptor	10474	2099	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human ADA3 binds to estrogen_receptor -LRB- ER -RRB- and functions as a coactivator for ER-mediated transactivation .
23645737	0	ADAL	39,43	adenosine_deaminase-like	13,37	ADAL	adenosine deaminase-like	161823	161823	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Mutations in adenosine_deaminase-like -LRB- ADAL -RRB- protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219 .
9428412	0	ADAM	33,37	SUP-17	0,6	ADAM	SUP-17	36037(Tax:7227)	172689(Tax:6239)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	SUP-17 , a Caenorhabditis_elegans ADAM protein related to Drosophila KUZBANIAN , and its role in LIN-12 / NOTCH signalling .
20087163	0	ADAM-17	0,7	ERK	53,56	ADAM-17	ERK	6868	5594	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	ADAM-17 is activated by the mitogenic protein kinase ERK in a model of kidney_fibrosis .
16619241	0	ADAM-17	25,32	FHL2	0,4	ADAM-17	FHL2	11491(Tax:10090)	14200(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity .
16373656	0	ADAM-9	0,6	interleukin-6	121,134	ADAM-9	interleukin-6	8754	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	ADAM-9 -LRB- MDC-9 / meltrin-gamma -RRB- , a member of the a disintegrin and metalloproteinase family , regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha -LRB- v -RRB- beta5 integrin .
12746310	0	ADAM-TS5	39,47	aggrecanase-2	25,38	ADAM-TS5	aggrecanase-2	304135(Tax:10116)	100008799(Tax:9986)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Thyroid hormone enhances aggrecanase-2 / ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage .
11342541	0	ADAM1	28,33	fertilin_alpha	12,26	ADAM1	fertilin alpha	280668(Tax:10090)	280668(Tax:10090)	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of fertilin_alpha -LRB- ADAM1 -RRB- - mediated sperm-egg cell adhesion during fertilization and identification of an adhesion-mediating sequence in the disintegrin-like domain .
12095680	0	ADAM1	44,49	fertilin_alpha	51,65	ADAM1	fertilin alpha	280668(Tax:10090)	280667(Tax:10090)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	The ADAM1a and ADAM1b genes , instead of the ADAM1 -LRB- fertilin_alpha -RRB- gene , are localized on mouse chromosome 5 .
22770404	0	ADAM10	8,14	CD16b	29,34	ADAM10	CD16b	102	2215	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of ADAM10 and ADAM17 in CD16b shedding mediated by different stimulators .
23025437	0	ADAM10	44,50	CD84	23,27	ADAM10	CD84	11487(Tax:10090)	12523(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets .
25130545	0	ADAM10	38,44	Dll4	109,113	ADAM10	Dll4	102	54567	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells .
15958533	0	ADAM10	0,6	E-cadherin	16,26	ADAM10	E-cadherin	11487(Tax:10090)	12550(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion , migration , and beta-catenin translocation .
19603142	0	ADAM10	103,109	E-cadherin	36,46	ADAM10	E-cadherin	102	999	Gene	Gene	activating|dobj|START_ENTITY induce|advcl|activating induce|dobj|degradation degradation|amod|END_ENTITY	Human mesenchymal stem cells induce E-cadherin degradation in breast_carcinoma spheroids by activating ADAM10 .
24255666	0	ADAM10	33,39	E-cadherin	88,98	ADAM10	E-cadherin	102	999	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular_carcinomas .
17290285	0	ADAM10	0,6	FasL	17,21	ADAM10	FasL	102	356	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death .
25130545	0	ADAM10	38,44	IL-6	96,100	ADAM10	IL-6	102	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells .
19371428	0	ADAM10	39,45	LRP1	0,4	ADAM10	LRP1	102	4035	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	LRP1 shedding in human brain : roles of ADAM10 and ADAM17 .
21876729	0	ADAM10	15,21	PAX2	0,4	ADAM10	PAX2	102	5076	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells .
21880579	0	ADAM10	40,46	PAX2	25,29	ADAM10	PAX2	102	5076	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The transcription factor PAX2 regulates ADAM10 expression in renal_cell_carcinoma .
22446748	0	ADAM10	85,91	Tetraspanin15	0,13	ADAM10	Tetraspanin15	102	23555	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10 .
26503019	0	ADAM12	14,20	E2F1	37,41	ADAM12	E2F1	8038	1869	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of ADAM12 is regulated by E2F1 in small_cell_lung_cancer .
11769731	0	ADAM12	15,21	Meltrin-alpha	23,36	ADAM12	Meltrin-alpha	8038	8038	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of ADAM12 -LRB- Meltrin-alpha -RRB- gene in giant_cell_tumor_of_bone -RSB- .
20457602	0	ADAM12	103,109	SnoN	12,16	ADAM12	SnoN	11489(Tax:10090)	20482(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of SnoN in transforming_growth_factor_beta1-induced expression of metalloprotease-disintegrin ADAM12 .
17620406	0	ADAM12	38,44	TGF-beta	60,68	ADAM12	TGF-beta	8038	7040	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor .
12456779	0	ADAM12	18,24	meltrin_alpha	26,39	ADAM12	meltrin alpha	8038	8038	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of ADAM12 -LRB- meltrin_alpha -RRB- in human giant_cell_tumours of bone .
11076687	0	ADAM13	58,64	PACSIN2	0,7	ADAM13	PACSIN2	386623(Tax:8355)	398138(Tax:8355)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13 .
23365087	0	ADAM15	65,71	TLR3	14,18	ADAM15	TLR3	8751	7098	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15 .
25246708	0	ADAM17	56,62	CD13	10,14	ADAM17	CD13	6868	290	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Targeting CD13 -LRB- aminopeptidase-N -RRB- in turn downregulates ADAM17 by internalization in acute_myeloid_leukaemia cells .
25816339	0	ADAM17	21,27	CD16	53,57	ADAM17	CD16	6868	2214	Gene	Gene	Region|compound|START_ENTITY Region|nmod|END_ENTITY	Identification of an ADAM17 Cleavage Region in Human CD16 -LRB- FcyRIII -RRB- and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells .
24965453	0	ADAM17	50,56	CD163	14,19	ADAM17	CD163	6868	9332	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine_reproductive_and_respiratory_syndrome_virus entry .
24189063	0	ADAM17	112,118	CD40	124,128	ADAM17	CD40	6868	958	Gene	Gene	START_ENTITY|nmod|manner manner|compound|END_ENTITY	CD154 is released from T-cells by a disintegrin and metalloproteinase domain-containing protein 10 -LRB- ADAM10 -RRB- and ADAM17 in a CD40 protein-dependent manner .
23211830	0	ADAM17	0,6	EGFR	22,26	ADAM17	EGFR	11491(Tax:10090)	13649(Tax:10090)	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	ADAM17 transactivates EGFR signaling during embryonic eyelid closure .
24793016	0	ADAM17	0,6	EMMPRIN	26,33	ADAM17	EMMPRIN	6868	682	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	ADAM17 is associated with EMMPRIN and predicts poor prognosis in patients with uterine cervical_carcinoma .
26561568	0	ADAM17	0,6	IL-6	16,20	ADAM17	IL-6	11491(Tax:10090)	16193(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Ra from the cell surface of leukocytes during inflammatory responses .
22384041	0	ADAM17	25,31	Interleukin-1	0,13	ADAM17	Interleukin-1	6868	3552	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735 .
22200661	0	ADAM17	0,6	MMP-2	15,20	ADAM17	MMP-2	6868	4313	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate_cancer cell invasion .
20551051	0	ADAM17	0,6	Notch1	87,93	ADAM17	Notch1	6868	4851	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	ADAM17 regulates epidermal_growth_factor_receptor expression through the activation of Notch1 in non-small_cell_lung_cancer .
23678045	0	ADAM17	0,6	Nox4	16,20	ADAM17	Nox4	11491(Tax:10090)	50490(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	ADAM17 mediates Nox4 expression and NADPH oxidase activity in the kidney cortex of OVE26 mice .
19772640	0	ADAM17	33,39	Sp1	21,24	ADAM17	Sp1	6868	6667	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia .
23684931	0	ADAM17	113,119	TGF-a	95,100	ADAM17	TGF-a	6868	7039	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Human breast_cancer-associated fibroblasts enhance cancer cell proliferation through increased TGF-a cleavage by ADAM17 .
21359495	0	ADAM17	80,86	TGF-b1	0,6	ADAM17	TGF-b1	6868	7040	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	TGF-b1 promotes motility and invasiveness of glioma cells through activation of ADAM17 .
21170088	0	ADAM17	0,6	TGFb	24,28	ADAM17	TGFb	6868	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	ADAM17 -LRB- TACE -RRB- regulates TGFb signaling through the cleavage of vasorin .
22018416	0	ADAM17	0,6	TNFa	17,21	ADAM17	TNFa	6868	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	ADAM17 regulates TNFa production by placental trophoblasts .
17155946	0	ADAM17	111,117	endothelial_protein_C_receptor	10,40	ADAM17	endothelial protein C receptor	6868	10544	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	Regulated endothelial_protein_C_receptor shedding is mediated by tumor_necrosis_factor-alpha_converting_enzyme / ADAM17 .
16840716	0	ADAM17	0,6	epidermal_growth_factor_receptor	16,48	ADAM17	epidermal growth factor receptor	6868	1956	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|transactivation transactivation|compound|END_ENTITY	ADAM17 mediates epidermal_growth_factor_receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin_II .
17227756	0	ADAM17	38,44	epidermal_growth_factor_receptor	50,82	ADAM17	epidermal growth factor receptor	6868	1956	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|activation activation|compound|END_ENTITY	Post-transcriptional up-regulation of ADAM17 upon epidermal_growth_factor_receptor activation and in breast_tumors .
20551051	0	ADAM17	0,6	epidermal_growth_factor_receptor	17,49	ADAM17	epidermal growth factor receptor	6868	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	ADAM17 regulates epidermal_growth_factor_receptor expression through the activation of Notch1 in non-small_cell_lung_cancer .
23850346	0	ADAM17	146,152	epidermal_growth_factor_receptor	53,85	ADAM17	epidermal growth factor receptor	6868	1956	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|dobj|activation activation|compound|END_ENTITY	Upregulation of Nox4 promotes angiotensin_II-induced epidermal_growth_factor_receptor activation and subsequent cardiac_hypertrophy by increasing ADAM17 expression .
24412389	0	ADAM17	40,46	epidermal_growth_factor_receptor	57,89	ADAM17	epidermal growth factor receptor	6868	1956	Gene	Gene	A_disintegrin_and_metalloproteinase_17|appos|START_ENTITY mediates|nsubj|A_disintegrin_and_metalloproteinase_17 mediates|dobj|transactivation transactivation|compound|END_ENTITY	A_disintegrin_and_metalloproteinase_17 -LRB- ADAM17 -RRB- mediates epidermal_growth_factor_receptor transactivation by angiotensin_II on hepatic stellate cells .
17884817	0	ADAM17	141,147	tumor_necrosis_factor-alpha_converting_enzyme	95,140	ADAM17	tumor necrosis factor-alpha converting enzyme	6868	6868	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Hypoxia-inducible factor mediates hypoxic and tumor_necrosis_factor_alpha-induced increases in tumor_necrosis_factor-alpha_converting_enzyme / ADAM17 expression by synovial cells .
10753657	0	ADAM19	14,20	Meltrin_beta	0,12	ADAM19	Meltrin beta	11492(Tax:10090)	303068(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Meltrin_beta -LRB- ADAM19 -RRB- gene : cloning , mapping , and analysis of the regulatory region .
9622634	0	ADAM19	84,90	meltrin_alpha	51,64	ADAM19	meltrin alpha	11492(Tax:10090)	11489(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Spatially - and temporally-restricted expression of meltrin_alpha -LRB- ADAM12 -RRB- and beta -LRB- ADAM19 -RRB- in mouse embryo .
11906941	0	ADAM2	146,151	fertilin_beta	131,144	ADAM2	fertilin beta	11495(Tax:10090)	11495(Tax:10090)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Analysis of the roles of RGD-binding integrins , alpha -LRB- 4 -RRB- / alpha -LRB- 9 -RRB- integrins , alpha -LRB- 6 -RRB- integrins , and CD9 in the interaction of the fertilin_beta -LRB- ADAM2 -RRB- disintegrin domain with the mouse egg membrane .
17681454	0	ADAM22	42,48	LGI1	28,32	ADAM22	LGI1	53616	9211	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal_dominant_lateral_temporal_epilepsy .
18974846	0	ADAM22	22,28	LGI1	0,4	ADAM22	LGI1	11496(Tax:10090)	56839(Tax:10090)	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	LGI1 and LGI4 bind to ADAM22 , ADAM23 and ADAM11 .
20971063	0	ADAM28	50,56	Connective_tissue_growth_factor	0,31	ADAM28	Connective tissue growth factor	10863	1490	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Connective_tissue_growth_factor is a substrate of ADAM28 .
14564349	0	ADAM33	53,59	a_disintegrin_and_metalloprotease_33	15,51	ADAM33	a disintegrin and metalloprotease 33	80332	80332	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a_disintegrin_and_metalloprotease_33 -LRB- ADAM33 -RRB- gene with asthma in ethnically diverse populations .
22447932	0	ADAM8	60,65	prion_protein	9,22	ADAM8	prion protein	11501(Tax:10090)	19122(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Cellular prion_protein regulates its own a-cleavage through ADAM8 in skeletal muscle .
23857158	0	ADAM9	63,68	A_disintegrin_and_metalloproteinase_9	24,61	ADAM9	A disintegrin and metalloproteinase 9	8754	8754	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Serum concentrations of A_disintegrin_and_metalloproteinase_9 -LRB- ADAM9 -RRB- mRNA as a promising novel marker for the detection of pulmonary_sarcoidosis .
22632802	0	ADAM9	20,25	MT1-MMP	0,7	ADAM9	MT1-MMP	8754	4323	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis .
22244942	0	ADAM9	22,27	Substance_P	0,11	ADAM9	Substance P	8754	6863	Gene	Gene	expression|nummod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Substance_P activates ADAM9 mRNA expression and induces a-secretase-mediated amyloid precursor protein cleavage .
18272597	0	ADAMTS-1	64,72	VEGF	82,86	ADAMTS-1	VEGF	79252(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Renal_ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1 , a novel VEGF inhibitor .
14760803	0	ADAMTS-1	0,8	interleukin_1beta	93,110	ADAMTS-1	interleukin 1beta	9510	3553	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|END_ENTITY	ADAMTS-1 , a gene product of articular chondrocytes in vivo and in vitro , is downregulated by interleukin_1beta .
12907688	0	ADAMTS-1	31,39	versican	68,76	ADAMTS-1	versican	11504(Tax:10090)	13003(Tax:10090)	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation .
21494557	0	ADAMTS-12	24,33	ADAMTS-12	75,84	ADAMTS-12	ADAMTS-12	81792	81792	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Regulated expression of ADAMTS-12 in human trophoblastic cells : a role for ADAMTS-12 in epithelial cell invasion ?
21494557	0	ADAMTS-12	75,84	ADAMTS-12	24,33	ADAMTS-12	ADAMTS-12	81792	81792	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Regulated expression of ADAMTS-12 in human trophoblastic cells : a role for ADAMTS-12 in epithelial cell invasion ?
26069660	0	ADAMTS-12	37,46	c-Maf	0,5	ADAMTS-12	c-Maf	81792	4094	Gene	Gene	Expression|compound|START_ENTITY Expression|amod|END_ENTITY	c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells .
16879212	0	ADAMTS-13	102,111	ADAMTS-13	34,43	ADAMTS-13	ADAMTS-13	11093	11093	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Inhibitory autoantibodies against ADAMTS-13 in patients with thrombotic_thrombocytopenic_purpura bind ADAMTS-13 protease and may accelerate its clearance in vivo .
16879212	0	ADAMTS-13	34,43	ADAMTS-13	102,111	ADAMTS-13	ADAMTS-13	11093	11093	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Inhibitory autoantibodies against ADAMTS-13 in patients with thrombotic_thrombocytopenic_purpura bind ADAMTS-13 protease and may accelerate its clearance in vivo .
21732076	0	ADAMTS-13	21,30	IL-1b	0,5	ADAMTS-13	IL-1b	11093	3553	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	IL-1b down-regulates ADAMTS-13 mRNA expression in cells of the central nervous system .
15524133	0	ADAMTS-13	58,67	Von_Willebrand_factor	18,39	ADAMTS-13	Von Willebrand factor	11093	7450	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	-LSB- Activity loss of Von_Willebrand_factor cleaving protein -LRB- ADAMTS-13 -RRB- is diagnostic for primary and pregnancy-related thrombotic_thrombocytopenic_purpura -RSB- .
12393397	0	ADAMTS-13	0,9	von_Willebrand_factor	52,73	ADAMTS-13	von Willebrand factor	11093	7450	Gene	Gene	cleaves|nsubj|START_ENTITY cleaves|dobj|multimers multimers|compound|END_ENTITY	ADAMTS-13 rapidly cleaves newly secreted ultralarge von_Willebrand_factor multimers on the endothelial surface under flowing conditions .
14995983	0	ADAMTS-13	60,69	von_Willebrand_factor	20,41	ADAMTS-13	von Willebrand factor	11093	7450	Gene	Gene	protease|dobj|START_ENTITY protease|nsubj|activity activity|nmod|cleaving cleaving|compound|END_ENTITY	The activity of the von_Willebrand_factor cleaving protease ADAMTS-13 in newborn infants .
15774619	0	ADAMTS-13	93,102	von_Willebrand_factor	36,57	ADAMTS-13	von Willebrand factor	11093	7450	Gene	Gene	mutants|nmod|START_ENTITY Cleavage|nmod|mutants Cleavage|nmod|multimers multimers|nmod|END_ENTITY	Cleavage of ultralarge multimers of von_Willebrand_factor by C-terminal-truncated mutants of ADAMTS-13 under flow .
19765212	0	ADAMTS-13	22,31	von_Willebrand_factor	35,56	ADAMTS-13	von Willebrand factor	11093	7450	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Multi-step binding of ADAMTS-13 to von_Willebrand_factor .
23682841	0	ADAMTS-13	44,53	von_Willebrand_factor	19,40	ADAMTS-13	von Willebrand factor	11093	7450	Gene	Gene	Normal|nmod|START_ENTITY Normal|dobj|cleavage cleavage|nmod|END_ENTITY	Normal cleavage of von_Willebrand_factor by ADAMTS-13 in the absence of factor VIII in patients with severe hemophilia __ A.
26232334	0	ADAMTS-2	19,27	IL-1a	47,52	ADAMTS-2	IL-1a	9509	3552	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of human ADAMTS-2 gene expression by IL-1a is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells .
16771712	0	ADAMTS-2	45,53	TIMP-3	0,6	ADAMTS-2	TIMP-3	9509	7078	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2 .
12646579	0	ADAMTS-2	63,71	Transforming_growth_factor-beta	0,31	ADAMTS-2	Transforming growth factor-beta	9509	7040	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Transforming_growth_factor-beta induces secretion of activated ADAMTS-2 .
17470431	0	ADAMTS-4	21,29	Aggrecanase-1	31,44	ADAMTS-4	Aggrecanase-1	9507	9507	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	TIMP-3 inhibition of ADAMTS-4 -LRB- Aggrecanase-1 -RRB- is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4 .
25709087	0	ADAMTS-4	77,85	Aggrecanase_1	87,100	ADAMTS-4	Aggrecanase 1	9507	9507	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	CCN1 -LRB- Cyr61 -RRB- Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 -LRB- Aggrecanase_1 -RRB- Activity .
14715656	0	ADAMTS-4	46,54	Alpha2-macroglobulin	0,20	ADAMTS-4	Alpha2-macroglobulin	9507	2	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes .
22324945	0	ADAMTS-4	40,48	Interleukin-6	0,13	ADAMTS-4	Interleukin-6	9507	3569	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid_arthritis .
24959676	0	ADAMTS-4	41,49	Matrilin-2	0,10	ADAMTS-4	Matrilin-2	9507	4147	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5 .
17470431	0	ADAMTS-4	21,29	TIMP-3	0,6	ADAMTS-4	TIMP-3	9507	7078	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	TIMP-3 inhibition of ADAMTS-4 -LRB- Aggrecanase-1 -RRB- is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4 .
24126638	0	ADAMTS-4	32,40	Tumor_necrosis_factor-a	0,23	ADAMTS-4	Tumor necrosis factor-a	9507	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-a induces ADAMTS-4 expression in human osteoarthritis chondrocytes .
23602832	0	ADAMTS-4	88,96	aggrecanase-1	73,86	ADAMTS-4	aggrecanase-1	9507	9507	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inflammatory cytokines associated with degenerative_disc_disease control aggrecanase-1 -LRB- ADAMTS-4 -RRB- expression in nucleus pulposus cells through MAPK and NF-kB .
18050214	0	ADAMTS-4	70,78	interleukin-1beta	39,56	ADAMTS-4	interleukin-1beta	9507	3553	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Involvement of protein_kinase_Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric_oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes .
18050214	0	ADAMTS-4	70,78	protein_kinase_Czeta	15,35	ADAMTS-4	protein kinase Czeta	9507	5590	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Involvement of protein_kinase_Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric_oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes .
24732836	0	ADAMTS-4	62,70	tumor_necrosis_factor_a	16,39	ADAMTS-4	tumor necrosis factor a	9507	7124	Gene	Gene	START_ENTITY|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of tumor_necrosis_factor_a and ADAMTS-5 , but not ADAMTS-4 , in human intervertebral cartilage_endplate with modic changes .
19767207	0	ADAMTS-5	74,82	Aggrecanase-2	84,97	ADAMTS-5	Aggrecanase-2	11096	11096	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis and SAR_of_2-phenyl-1-sulfonylaminocyclopropane_carboxylates as ADAMTS-5 -LRB- Aggrecanase-2 -RRB- inhibitors .
27067395	0	ADAMTS-5	23,31	IL-1b	4,9	ADAMTS-5	IL-1b	11096	3553	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	The IL-1b / AP-1 / miR-30a / ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis .
19684582	0	ADAMTS-5	21,29	Syndecan-4	0,10	ADAMTS-5	Syndecan-4	23794(Tax:10090)	20971(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown_in_osteoarthritis .
17067994	0	ADAMTS-5	14,22	implantin	23,32	ADAMTS-5	implantin	11096	23794(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of ADAMTS-5 / implantin in human decidual stromal cells : regulatory effects of cytokines .
26446668	0	ADAMTS-7	16,24	IL-17A	0,6	ADAMTS-7	IL-17A	11173	3605	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-17A enhances ADAMTS-7 expression through regulation of TNF-a in human nucleus pulposus cells .
19487464	0	ADAMTS-7	0,8	PTHrP	29,34	ADAMTS-7	PTHrP	11173	5744	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	ADAMTS-7 , a direct target of PTHrP , adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor .
15880812	0	ADAMTS-9	0,8	interleukin-1beta	39,56	ADAMTS-9	interleukin-1beta	56999	3553	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	ADAMTS-9 is synergistically induced by interleukin-1beta and tumor_necrosis_factor_alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes .
26563155	0	ADAMTS1	65,72	A_disintegrin_and_metalloproteinase_with_thrombospondin_motif_1	0,63	ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motif 1	9510	9510	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A_disintegrin_and_metalloproteinase_with_thrombospondin_motif_1 -LRB- ADAMTS1 -RRB- expression increases in acute aortic dissection .
18267097	0	ADAMTS1	27,34	Brg1	12,16	ADAMTS1	Brg1	9510	6597	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis .
26299656	0	ADAMTS1	36,43	SP1	0,3	ADAMTS1	SP1	9510	6667	Gene	Gene	expression|nummod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	SP1 and USF differentially regulate ADAMTS1 gene expression under normoxic and hypoxic_conditions in hepatoma cells .
17082774	0	ADAMTS1	0,7	TSP1_and_2	65,75	ADAMTS1	TSP1 and 2	11504(Tax:10090)	108314;104266	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1_and_2 .
16936124	0	ADAMTS1	61,68	Vascular_endothelial_growth_factor	0,34	ADAMTS1	Vascular endothelial growth factor	11504(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor upregulates expression of ADAMTS1 in endothelial cells through protein kinase C signaling .
19915008	0	ADAMTS1	41,48	semaphorin_3C	16,29	ADAMTS1	semaphorin 3C	9510	10512	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The cleavage of semaphorin_3C induced by ADAMTS1 promotes cell migration .
12871537	0	ADAMTS13	87,95	ABO_blood_group	16,31	ADAMTS13	ABO blood group	11093	28	Gene	Gene	influence|nmod|START_ENTITY influence|nmod|END_ENTITY	An influence of ABO_blood_group on the rate of proteolysis of von_Willebrand factor by ADAMTS13 .
21840304	0	ADAMTS13	0,8	ABO_blood_group	40,55	ADAMTS13	ABO blood group	11093	28	Gene	Gene	von_Willebrand|nsubj|START_ENTITY von_Willebrand|dobj|assessment assessment|dep|END_ENTITY	ADAMTS13 , FVIII , von_Willebrand factor , ABO_blood_group assessment in preeclampsia .
17610557	0	ADAMTS13	72,80	C1584	0,5	ADAMTS13	C1584	11093	1035340(Tax:199310)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	C1584 in von_Willebrand_factor is necessary for enhanced proteolysis by ADAMTS13 in vitro .
18006046	0	ADAMTS13	25,33	Unbalanced	0,10	ADAMTS13	Unbalanced	11093	21829(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Unbalanced expression of ADAMTS13 and von_Willebrand factor in mouse endotoxinemia .
16204318	0	ADAMTS13	139,147	VWF	118,121	ADAMTS13	VWF	279028(Tax:10090)	22371(Tax:10090)	Gene	Gene	protecting|nmod|START_ENTITY protecting|dobj|END_ENTITY	Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting -LRB- sub -RRB- endothelial VWF from cleavage by ADAMTS13 .
17975018	0	ADAMTS13	61,69	VWF	26,29	ADAMTS13	VWF	11093	7450	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|glycosylation glycosylation|nmod|END_ENTITY	N-linked glycosylation of VWF modulates its interaction with ADAMTS13 .
19587373	0	ADAMTS13	25,33	VWF	84,87	ADAMTS13	VWF	11093	7450	Gene	Gene	site|nmod|START_ENTITY exposed|nsubj|site exposed|nmod|surface surface|nmod|END_ENTITY	A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF .
20032502	0	ADAMTS13	72,80	VWF	142,145	ADAMTS13	VWF	11093	7450	Gene	Gene	domain|compound|START_ENTITY residues|nmod|domain comprising|advcl|residues epitope|acl|comprising identifies|nsubj|epitope identifies|dobj|site site|nmod|END_ENTITY	An autoantibody epitope comprising residues R660 , Y661 , and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF .
20695979	0	ADAMTS13	45,53	VWF	98,101	ADAMTS13	VWF	279028(Tax:10090)	22371(Tax:10090)	Gene	Gene	proteolysis|compound|START_ENTITY proteolysis|nmod|strings strings|compound|END_ENTITY	The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo .
22070827	0	ADAMTS13	7,15	VWF	40,43	ADAMTS13	VWF	11093	7450	Gene	Gene	START_ENTITY|appos|factor factor|appos|END_ENTITY	Plasma ADAMTS13 , von_Willebrand factor -LRB- VWF -RRB- and VWF propeptide profiles in patients with DIC and related_diseases .
22323407	0	ADAMTS13	14,22	VWF	5,8	ADAMTS13	VWF	11093	7450	Gene	Gene	puts|nsubj|START_ENTITY puts|nsubj|END_ENTITY	High VWF , low ADAMTS13 puts women at risk .
25564400	0	ADAMTS13	16,24	VWF	49,52	ADAMTS13	VWF	11093	7450	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis .
26345337	0	ADAMTS13	115,123	VWF	108,111	ADAMTS13	VWF	11093	7450	Gene	Gene	type|nmod|START_ENTITY type|nmod|END_ENTITY	The co-influence of VWD type 2B/2M mutations in the A1 domain and platelet GPIba on the rate of cleavage to VWF by ADAMTS13 .
26345337	0	ADAMTS13	115,123	VWF	108,111	ADAMTS13	VWF	11093	7450	Gene	Gene	type|nmod|START_ENTITY type|nmod|END_ENTITY	The co-influence of VWD type 2B/2M mutations in the A1 domain and platelet GPIba on the rate of cleavage to VWF by ADAMTS13 .
26759371	0	ADAMTS13	7,15	VWF	40,43	ADAMTS13	VWF	11093	7450	Gene	Gene	START_ENTITY|appos|von_Willebrand_Factor von_Willebrand_Factor|appos|END_ENTITY	Plasma ADAMTS13 , von_Willebrand_Factor -LRB- VWF -RRB- , and VWF Propeptide Profiles in Patients With Connective Tissue Diseases and Antiphospholipid_Syndrome .
14962303	0	ADAMTS13	44,52	VWF-cleaving_protease	21,42	ADAMTS13	VWF-cleaving protease	11093	11093	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Severe deficiency of VWF-cleaving_protease -LRB- ADAMTS13 -RRB- activity defines a distinct population of thrombotic_microangiopathy patients .
15224369	0	ADAMTS13	44,52	VWF_cleaving_protease	21,42	ADAMTS13	VWF cleaving protease	11093	11093	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Simplified assay for VWF_cleaving_protease -LRB- ADAMTS13 -RRB- activity and inhibitor in plasma .
20553378	0	ADAMTS13	16,24	plasmin	28,35	ADAMTS13	plasmin	11093	5340	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic_thrombocytopenic_purpura .
15388580	0	ADAMTS13	28,36	thrombin	40,48	ADAMTS13	thrombin	11093	2147	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Proteolytic inactivation of ADAMTS13 by thrombin and plasmin .
15735809	0	ADAMTS13	11,19	von-Willebrand-factor-cleaving_protease	21,60	ADAMTS13	von-Willebrand-factor-cleaving protease	11093	11093	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Changes in ADAMTS13 -LRB- von-Willebrand-factor-cleaving_protease -RRB- activity after induced release of von_Willebrand_factor_during_acute_systemic_inflammation .
15583740	0	ADAMTS13	41,49	von_Willebrand_factor-cleaving_protease	0,39	ADAMTS13	von Willebrand factor-cleaving protease	11093	11093	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	von_Willebrand_factor-cleaving_protease -LRB- ADAMTS13 -RRB- activity in normal non-pregnant women , pregnant and post-delivery women .
18295305	0	ADAMTS13	59,67	von_Willebrand_factor-cleaving_protease	18,57	ADAMTS13	von Willebrand factor-cleaving protease	11093	11093	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Changes in plasma von_Willebrand_factor-cleaving_protease -LRB- ADAMTS13 -RRB- levels in patients with unstable_angina .
20135067	0	ADAMTS13	68,76	von_Willebrand_factor-cleaving_protease	27,66	ADAMTS13	von Willebrand factor-cleaving protease	11093	11093	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Prognostic value of plasma von_Willebrand_factor-cleaving_protease -LRB- ADAMTS13 -RRB- antigen levels in patients with coronary_artery_disease .
11254106	0	ADAMTS4	63,70	aggrecanase-1	48,61	ADAMTS4	aggrecanase-1	9507	9507	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Characterization of 5 ' - flanking region of human aggrecanase-1 -LRB- ADAMTS4 -RRB- gene .
11311239	0	ADAMTS4	14,21	aggrecanase-1	23,36	ADAMTS4	aggrecanase-1	9507	9507	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition of ADAMTS4 -LRB- aggrecanase-1 -RRB- by tissue_inhibitors_of_metalloproteinases -LRB- TIMP-1 , _ 2 , _ 3_and_4 -RRB- .
17922681	0	ADAMTS4	14,21	aggrecanase-1	23,36	ADAMTS4	aggrecanase-1	9507	9507	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of ADAMTS4 -LRB- aggrecanase-1 -RRB- in human osteoarthritic cartilage .
26136925	0	ADAMTS4	48,55	osteopontin	10,21	ADAMTS4	osteopontin	9507	6696	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of osteopontin on the mRNA expression of ADAMTS4 and ADAMTS5 in chondrocytes from patients with knee_osteoarthritis .
11311239	0	ADAMTS4	14,21	tissue_inhibitors_of_metalloproteinases	41,80	ADAMTS4	tissue inhibitors of metalloproteinases	9507	7076	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ADAMTS4 -LRB- aggrecanase-1 -RRB- by tissue_inhibitors_of_metalloproteinases -LRB- TIMP-1 , _ 2 , _ 3_and_4 -RRB- .
19833888	0	ADAMTS9	70,77	BCL11A	79,85	ADAMTS9	BCL11A	56999	53335	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D , THADA , ADAMTS9 , BCL11A , and MTNR1B affect different aspects of pancreatic beta-cell function .
23175174	0	ADAMTS9	16,23	IL-1b	43,48	ADAMTS9	IL-1b	56999	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Augmentation of ADAMTS9 gene expression by IL-1b is reversed by NFkB and MAPK inhibitors , but not PI3 kinase inhibitors .
19833888	0	ADAMTS9	70,77	THADA	63,68	ADAMTS9	THADA	56999	63892	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D , THADA , ADAMTS9 , BCL11A , and MTNR1B affect different aspects of pancreatic beta-cell function .
19052845	0	ADAMTS9	0,7	interleukin_1_beta	22,40	ADAMTS9	interleukin 1 beta	56999	3553	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	ADAMTS9 activation by interleukin_1_beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes .
9417060	0	ADAM_12	32,39	meltrin_alpha	41,54	ADAM 12	meltrin alpha	8038	8038	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	A novel , secreted form of human ADAM_12 -LRB- meltrin_alpha -RRB- provokes myogenesis in vivo .
12441351	0	ADAM_17	46,53	MUC1	63,67	ADAM 17	MUC1	6868	4582	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Tumor_necrosis_factor-alpha_converting_enzyme / ADAM_17 mediates MUC1 shedding .
11360299	0	ADAM_17	45,52	TACE	54,58	ADAM 17	TACE	6868	6868	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Astrocyte and endothelial cell expression of ADAM_17 -LRB- TACE -RRB- in adult human CNS .
12441351	0	ADAM_17	46,53	Tumor_necrosis_factor-alpha_converting_enzyme	0,45	ADAM 17	Tumor necrosis factor-alpha converting enzyme	6868	6868	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Tumor_necrosis_factor-alpha_converting_enzyme / ADAM_17 mediates MUC1 shedding .
20957749	0	ADAP	19,23	HPK1	0,4	ADAP	HPK1	2533	11184	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion .
17478723	0	ADAP	86,90	NF-kappaB	14,23	ADAP	NF-kappaB	23880(Tax:10090)	18033(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activation activation|amod|END_ENTITY	Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1 .
23979596	0	ADAP	47,51	SLP-76	26,32	ADAP	SLP-76	2533	3937	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells .
23979596	0	ADAP	47,51	SLP-76	87,93	ADAP	SLP-76	2533	3937	Gene	Gene	domain|nmod|START_ENTITY Multipoint|nmod|domain critical|nsubj|Multipoint critical|nmod|oligomerization oligomerization|nmod|END_ENTITY	Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells .
18802088	0	ADAP	118,122	adapter_protein	102,117	ADAP	adapter protein	23880(Tax:10090)	23880(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa_B activation by the adapter_protein ADAP .
16020549	0	ADAP	103,107	c-Src_and_adhesion_and_degranulation_promoting_adaptor_protein	39,101	ADAP	c-Src and adhesion and degranulation promoting adaptor protein	23880(Tax:10090)	23880(Tax:10090)	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Physical and functional association of c-Src_and_adhesion_and_degranulation_promoting_adaptor_protein -LRB- ADAP -RRB- in osteoclastogenesis in vitro .
24067935	0	ADAR1	0,5	ARHGAP26	16,24	ADAR1	ARHGAP26	103	23092	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	ADAR1 regulates ARHGAP26 gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding .
16055709	0	ADAR1	0,5	NF90	21,25	ADAR1	NF90	103	3609	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing .
11070079	0	ADAR1	58,63	PKR	172,175	ADAR1	PKR	103	5610	Gene	Gene	proteins|compound|START_ENTITY reveal|nsubj|proteins reveal|nmod|END_ENTITY	Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR .
19605474	0	ADAR1	0,5	PKR	21,24	ADAR1	PKR	103	5610	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ADAR1 interacts with PKR during human immunodeficiency virus_infection of lymphocytes and contributes to viral replication .
19710021	0	ADAR1	33,38	PKR	115,118	ADAR1	PKR	103	5610	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|apoptosis apoptosis|nmod|END_ENTITY	RNA-specific adenosine deaminase ADAR1 suppresses measles_virus-induced apoptosis and activation of protein kinase PKR .
19913273	0	ADAR1	24,29	PKR	89,92	ADAR1	PKR	103	5610	Gene	Gene	deficiency|compound|START_ENTITY leads|nsubj|deficiency leads|nmod|activation activation|nmod|END_ENTITY	RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular_stomatitis virus growth following interferon treatment .
25389016	0	ADAR1	0,5	PKR	67,70	ADAR1	PKR	103	5610	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity .
26047657	0	ADAR1	14,19	PTBP1	0,5	ADAR1	PTBP1	103	5725	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas .
9707437	0	ADAR1	103,108	Tad1p	0,5	ADAR1	Tad1p	103	852608(Tax:4932)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Tad1p , a yeast tRNA-specific_adenosine_deaminase , is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2 .
24813121	0	ADAR1	55,60	c-Myc	80,85	ADAR1	c-Myc	103	4609	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Novel interaction of the Z-DNA binding domain of human ADAR1 with the oncogenic c-Myc promoter G-quadruplex .
24906008	0	ADAR1	31,36	p150	38,42	ADAR1	p150	103	10036	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Reovirus-mediated induction of ADAR1 -LRB- p150 -RRB- minimally alters RNA editing patterns in discrete brain regions .
25409942	0	ADC	32,35	Arginine_decarboxylase	8,30	ADC	Arginine decarboxylase	816149(Tax:3702)	816149(Tax:3702)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Arginine_decarboxylase -LRB- ADC -RRB- in Arabidopsis_thaliana defence against the pathogenic bacterium Pseudomonas_viridiflava .
26866375	0	ADCK3	33,38	AarF_Domain_Containing_Kinase_3	0,31	ADCK3	AarF Domain Containing Kinase 3	56997	56997	Gene	Gene	Cells|appos|START_ENTITY Cells|amod|END_ENTITY	AarF_Domain_Containing_Kinase_3 -LRB- ADCK3 -RRB- Mutant Cells Display Signs of Oxidative Stress , Defects_in_Mitochondrial_Homeostasis_and_Lysosomal_Accumulation .
11968092	0	ADCYAP1	103,110	adenylate_cyclase_activating_polypeptide_1	59,101	ADCYAP1	adenylate cyclase activating polypeptide 1	116	116	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation screening and association studies of the adenylate_cyclase_activating_polypeptide_1 -LRB- ADCYAP1 -RRB- gene in patients with type 2 diabetes .
11101056	0	ADD-1	40,45	SREBP-1	46,53	ADD-1	SREBP-1	118	6720	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Ritonavir increases the level of active ADD-1 / SREBP-1 protein during adipogenesis .
12951058	0	ADD2	69,73	beta4	74,79	ADD2	beta4	119	10381	Gene	Gene	variants|nummod|START_ENTITY variants|amod|END_ENTITY	Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants .
19525417	0	ADE3	26,30	Gcn4p	48,53	ADE3	Gcn4p	853118(Tax:4932)	856709(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY transcription|nsubj|regulation transcription|nmod|END_ENTITY	Cooperative regulation of ADE3 transcription by Gcn4p and Bas1p in Saccharomyces_cerevisiae .
12115702	0	ADF	22,25	WDR1	0,4	ADF	WDR1	396539(Tax:9031)	422842(Tax:9031)	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	WDR1 colocalizes with ADF and actin in the normal and noise-damaged chick cochlea .
16447258	0	ADF	19,22	tyrosinase	37,47	ADF	tyrosinase	11034	7299	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	Human glioblastoma ADF cells express tyrosinase , L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea .
16968708	0	ADFP	90,94	Tip47	78,83	ADFP	Tip47	11520(Tax:10090)	66905(Tax:10090)	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	Functional compensation for adipose_differentiation-related_protein -LRB- ADFP -RRB- by Tip47 in an ADFP null embryonic cell line .
3521328	0	ADH	51,54	Angiotensin_II	0,14	ADH	Angiotensin II	551	183	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Angiotensin_II inhibition with captopril on plasma ADH , PG synthesis , and renal function in humans .
7497088	0	ADH	50,53	alcohol_dehydrogenase	27,48	ADH	alcohol dehydrogenase	78959(Tax:10116)	78959(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effect of endotoxin on alcohol_dehydrogenase -LRB- ADH -RRB- activity in the serum of ethanol intoxicated rats .
167172	0	ADH	45,48	antidiuretic_hormone	23,43	ADH	antidiuretic hormone	551	551	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	The membrane action of antidiuretic_hormone -LRB- ADH -RRB- on toad urinary bladder .
2682381	0	ADH	34,37	antidiuretic_hormone	12,32	ADH	antidiuretic hormone	551	551	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	-LSB- Changes in antidiuretic_hormone -LRB- ADH -RRB- in liver_cirrhosis with resistant ascites -RSB- .
2169444	0	ADH1	52,56	ADH2	147,151	ADH1	ADH2	124	125	Gene	Gene	genes|nummod|START_ENTITY dehydrogenase|xcomp|genes dehydrogenase|parataxis|flanking flanking|dobj|box box|compound|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
2169444	0	ADH1	52,56	ADH2	58,62	ADH1	ADH2	124	125	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
8634148	0	ADH1	132,136	ADH2	138,142	ADH1	ADH2	124	125	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Gene expression in a young multigene family : tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 .
17414625	0	ADH1	0,4	N-cadherin	9,19	ADH1	N-cadherin	124	1000	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	ADH1 , an N-cadherin inhibitor , evaluated in preclinical models of angiogenesis and androgen-independent prostate_cancer .
23891545	0	ADH1	41,45	alcohol_dehydrogenase-1	16,39	ADH1	alcohol dehydrogenase-1	124	124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of the alcohol_dehydrogenase-1 -LRB- ADH1 -RRB- gene in the pathomechanism of uterine_leiomyoma .
16153155	0	ADH1A	66,71	alcohol_dehydrogenase_1A	40,64	ADH1A	alcohol dehydrogenase 1A	124	124	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	GATA-2_and_HNF-3beta regulate the human alcohol_dehydrogenase_1A -LRB- ADH1A -RRB- gene .
22144473	0	ADH1B	51,56	alcohol_dehydrogenase	21,42	ADH1B	alcohol dehydrogenase	125	124	Gene	Gene	ADH1A|dep|START_ENTITY END_ENTITY|appos|ADH1A	Genetic variation in alcohol_dehydrogenase -LRB- ADH1A , ADH1B , ADH1C , ADH7 -RRB- and aldehyde_dehydrogenase -LRB- ALDH2 -RRB- , alcohol consumption and gastric_cancer risk in the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- cohort .
26379912	0	ADH1C	26,31	Alcohol_dehydrogenase_1C	0,24	ADH1C	Alcohol dehydrogenase 1C	126	126	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alcohol_dehydrogenase_1C -LRB- ADH1C -RRB- gene polymorphism and alcoholic_liver_cirrhosis risk : a meta analysis .
15318112	0	ADH1C	9,14	DRD2	18,22	ADH1C	DRD2	126	1813	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	ADH1B * 1 , ADH1C * 2 , DRD2 -LRB- -141 C Ins -RRB- , and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles .
12489990	0	ADH1C	98,103	alcohol_dehydrogenase_1C	72,96	ADH1C	alcohol dehydrogenase 1C	126	126	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A retroviral repetitive element confers tissue-specificity to the human alcohol_dehydrogenase_1C -LRB- ADH1C -RRB- gene .
15643610	0	ADH1C	86,91	alcohol_dehydrogenase_1C	60,84	ADH1C	alcohol dehydrogenase 1C	126	126	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Natural haplotypes in the regulatory sequences affect human alcohol_dehydrogenase_1C -LRB- ADH1C -RRB- gene expression .
2169444	0	ADH2	147,151	ADH1	52,56	ADH2	ADH1	125	124	Gene	Gene	box|compound|START_ENTITY flanking|dobj|box dehydrogenase|parataxis|flanking dehydrogenase|xcomp|genes genes|nummod|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
2169444	0	ADH2	58,62	ADH1	52,56	ADH2	ADH1	125	124	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
8634148	0	ADH2	138,142	ADH1	132,136	ADH2	ADH1	125	124	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Gene expression in a young multigene family : tissue-specific differences in the expression of the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 .
2169444	0	ADH2	147,151	ADH2	58,62	ADH2	ADH2	125	125	Gene	Gene	box|compound|START_ENTITY flanking|dobj|box dehydrogenase|parataxis|flanking dehydrogenase|xcomp|genes genes|nummod|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
2169444	0	ADH2	58,62	ADH2	147,151	ADH2	ADH2	125	125	Gene	Gene	genes|nummod|START_ENTITY dehydrogenase|xcomp|genes dehydrogenase|parataxis|flanking flanking|dobj|box box|compound|END_ENTITY	Promoters for the human alcohol dehydrogenase genes ADH1 , ADH2 , and ADH3 : interaction of CCAAT/enhancer-binding protein with elements flanking the ADH2 TATA box .
11495982	0	ADH2	88,92	Adr1	0,4	ADH2	Adr1	855349(Tax:4932)	851802(Tax:4932)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Adr1 and Cat8 synergistically activate the glucose-regulated alcohol dehydrogenase gene ADH2 of the yeast Saccharomyces_cerevisiae .
26221330	0	ADH2	49,53	alcohol_dehydrogenase_2	24,47	ADH2	alcohol dehydrogenase 2	125	125	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphism in alcohol_dehydrogenase_2 -LRB- ADH2 -RRB- gene and alcoholic_liver_cirrhosis risk .
26221330	0	ADH2	49,53	alcohol_dehydrogenase_2	24,47	ADH2	alcohol dehydrogenase 2	125	125	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphism in alcohol_dehydrogenase_2 -LRB- ADH2 -RRB- gene and alcoholic_liver_cirrhosis risk .
11527411	0	ADH3	51,55	alcohol_dehydrogenase	28,49	ADH3	alcohol dehydrogenase	116517(Tax:7955)	116517(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of alcohol_dehydrogenase -LRB- ADH3 -RRB- in zebrafish -LRB- Danio_rerio -RRB- .
11740346	0	ADH3	56,60	alcohol_dehydrogenase_3	31,54	ADH3	alcohol dehydrogenase 3	128	128	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Functional polymorphism in the alcohol_dehydrogenase_3 -LRB- ADH3 -RRB- promoter .
19182438	0	ADH4	82,86	alcohol_dehydrogenase	59,80	ADH4	alcohol dehydrogenase	127	127	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the promoter region of the human class II alcohol_dehydrogenase -LRB- ADH4 -RRB- gene affect both transcriptional activity and ethanol metabolism in Japanese subjects .
11916005	0	ADH4	80,84	alcohol_dehydrogenase_4	55,78	ADH4	alcohol dehydrogenase 4	127	127	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Thirteen single-nucleotide polymorphisms -LRB- SNPs -RRB- in the alcohol_dehydrogenase_4 -LRB- ADH4 -RRB- gene locus .
19925625	0	ADH4	65,69	alcohol_dehydrogenase_4	40,63	ADH4	alcohol dehydrogenase 4	127	127	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cluster_headache is associated with the alcohol_dehydrogenase_4 -LRB- ADH4 -RRB- gene .
1881901	0	ADH6	36,40	alcohol_dehydrogenase	8,29	ADH6	alcohol dehydrogenase	130	10327	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A human alcohol_dehydrogenase gene -LRB- ADH6 -RRB- encoding an additional class of isozyme .
16180008	0	ADH7	93,97	alcohol_dehydrogenase	62,83	ADH7	alcohol dehydrogenase	131	10327	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Identification of new single nucleotid polymorphisms -LRB- SNP -RRB- in alcohol_dehydrogenase class IV ADH7 gene within a French population .
22144473	0	ADH7	65,69	alcohol_dehydrogenase	21,42	ADH7	alcohol dehydrogenase	131	124	Gene	Gene	ADH1A|dep|START_ENTITY END_ENTITY|appos|ADH1A	Genetic variation in alcohol_dehydrogenase -LRB- ADH1A , ADH1B , ADH1C , ADH7 -RRB- and aldehyde_dehydrogenase -LRB- ALDH2 -RRB- , alcohol consumption and gastric_cancer risk in the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- cohort .
8082805	0	ADH7	75,79	alcohol_dehydrogenase	47,68	ADH7	alcohol dehydrogenase	131	10327	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization of a class IV human alcohol_dehydrogenase gene -LRB- ADH7 -RRB- .
10606766	0	ADHII	101,106	9-cis-retinol_dehydrogenase	26,53	ADHII	9-cis-retinol dehydrogenase	29646(Tax:10116)	366791(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Analysis of rat cytosolic 9-cis-retinol_dehydrogenase activity and enzymatic characterization of rat ADHII .
18523726	0	ADIPOQ	17,23	Adiponectin	0,11	ADIPOQ	Adiponectin	9370	9370	Gene	Gene	START_ENTITY|nsubj|gene gene|compound|END_ENTITY	Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity .
24894086	0	ADIPOQ	18,24	Adiponectin	0,11	ADIPOQ	Adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Adiponectin gene -LRB- ADIPOQ -RRB- polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type_2_diabetes .
18776141	0	ADIPOQ	41,47	adiponectin	23,34	ADIPOQ	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Common variants in the adiponectin gene -LRB- ADIPOQ -RRB- associated with plasma adiponectin levels , type 2 diabetes , and diabetes-related quantitative traits : the Framingham Offspring Study .
19178518	0	ADIPOQ	35,41	adiponectin	22,33	ADIPOQ	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutation in the adiponectin -LRB- ADIPOQ -RRB- gene is associated with hypoadiponectinaemia in Japanese-Brazilians .
21619462	0	ADIPOQ	25,31	adiponectin	12,23	ADIPOQ	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The role of adiponectin -LRB- ADIPOQ -RRB- gene polymorphisms in the susceptibility and prognosis of non-small_cell_lung_cancer .
24528335	0	ADIPOQ	28,34	adiponectin	15,26	ADIPOQ	adiponectin	9370	9370	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of adiponectin -LRB- ADIPOQ -RRB- rs2241766 polymorphism and dyslipidemia in HIV/HCV-coinfected patients .
23813974	0	ADIPOR1	127,134	ANRIL	25,30	ADIPOR1	ANRIL	51094	100048912	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The large non-coding RNA ANRIL , which is associated with atherosclerosis , periodontitis and several forms of cancer , regulates ADIPOR1 , VAMP3 and C11ORF10 .
15277397	0	ADIPOR1	29,36	Adiponectin_receptor_1	0,22	ADIPOR1	Adiponectin receptor 1	51094	51094	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Adiponectin_receptor_1 gene -LRB- ADIPOR1 -RRB- as a candidate for type 2 diabetes and insulin resistance .
22387454	0	ADIPOR1	29,36	Adiponectin_receptor_1	0,22	ADIPOR1	Adiponectin receptor 1	51094	51094	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Adiponectin_receptor_1 gene -LRB- ADIPOR1 -RRB- variant is associated with advanced age-related_macular_degeneration in Finnish population .
17716299	0	ADIPOR1	44,51	adiponectin	17,28	ADIPOR1	adiponectin	51094	9370	Gene	Gene	Polymorphisms|dep|START_ENTITY Polymorphisms|nmod|genes genes|amod|END_ENTITY	Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance .
20178558	0	ADIPOR2	49,56	adiponectin_receptor_2	25,47	ADIPOR2	adiponectin receptor 2	79602	79602	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the adiponectin_receptor_2 -LRB- ADIPOR2 -RRB- gene is associated with coronary_artery_disease and increased ADIPOR2 expression in peripheral monocytes .
17234742	0	ADIR	151,155	ATP-dependent_interferon-responsive	114,149	ADIR	ATP-dependent interferon-responsive	64222	64222	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple_myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent_interferon-responsive -LRB- ADIR -RRB- gene .
9877221	0	ADM	127,130	adrenomedullin	21,35	ADM	adrenomedullin	133	133	Gene	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	Inhibitory effect of adrenomedullin -LRB- ADM -RRB- on the aldosterone response of human adrenocortical cells to angiotensin-II : role of ADM -LRB- 22-52 -RRB- - sensitive receptors .
19844808	0	ADNP	44,48	Activity-dependent_neuroprotective_protein	0,42	ADNP	Activity-dependent neuroprotective protein	11538(Tax:10090)	11538(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- expression in the amyloid precursor protein/presenilin _ 1 mouse model of Alzheimer 's _ disease .
15974912	0	ADNP	62,66	activity-dependent_neuroprotective_protein	18,60	ADNP	activity-dependent neuroprotective protein	11538(Tax:10090)	11538(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- is regulated by brain_damage and treatment of mice with the ADNP derived peptide , NAP , reduces the severity of traumatic head_injury .
17952637	0	ADNP	90,94	activity-dependent_neuroprotective_protein	46,88	ADNP	activity-dependent neuroprotective protein	11538(Tax:10090)	11538(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vasoactive intestinal peptide -LRB- VIP -RRB- regulates activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- expression in vivo .
18375135	0	ADNP	58,62	activity-dependent_neuroprotective_protein	14,56	ADNP	activity-dependent neuroprotective protein	23394	23394	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- by the NO-cGMP pathway in the hippocampus during kainic_acid-induced seizure .
26071584	0	ADNP	104,108	neurotrophin	82,94	ADNP	neurotrophin	23394	627	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Assessment of plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- , activity-dependent neurotrophin protein -LRB- ADNP -RRB- and vasoactive intestinal peptide -LRB- VIP -RRB- concentrations in treatment-na ve humans with multiple_sclerosis .
17329997	0	ADORA2A	56,63	adenosine_A2A_receptor	27,49	ADORA2A	adenosine A2A receptor	135	135	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A genetic variation in the adenosine_A2A_receptor gene -LRB- ADORA2A -RRB- contributes to individual sensitivity to caffeine effects on sleep .
20716228	0	ADORA3	53,59	adenosine_A3_receptor	30,51	ADORA3	adenosine A3 receptor	140	140	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional variability of the adenosine_A3_receptor -LRB- ADORA3 -RRB- gene polymorphism in aspirin-induced_urticaria .
9293494	0	ADORA3	89,95	adenosine_A3_receptor	66,87	ADORA3	adenosine A3 receptor	140	140	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning , characterisation and chromosomal assignment of the human adenosine_A3_receptor -LRB- ADORA3 -RRB- gene .
19774490	0	ADP	83,86	adipose_differentiation-related_protein	42,81	ADP	adipose differentiation-related protein	427237(Tax:9031)	427237(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Tissue-specific expression of the chicken adipose_differentiation-related_protein -LRB- ADP -RRB- gene .
25296758	0	ADP-ribosylation_Factor_6	139,164	EFA6R	16,21	ADP-ribosylation Factor 6	EFA6R	382	23362	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nmod|Activation	Exchange Factor EFA6R Requires C-terminal Targeting to the Plasma Membrane to Promote Cytoskeletal Rearrangement through the Activation of ADP-ribosylation_Factor_6 -LRB- ARF6 -RRB- .
11909968	0	ADP-ribosylation_factor-like_4	86,116	Arl4	118,122	ADP-ribosylation factor-like 4	Arl4	11861(Tax:10090)	11861(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation_factor-like_4 -LRB- Arl4 -RRB- gene .
23807224	0	ADP-ribosylation_factor-like_protein_2	21,59	MicroRNA-195	0,12	ADP-ribosylation factor-like protein 2	MicroRNA-195	402	406971	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-195 targets ADP-ribosylation_factor-like_protein_2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells .
9688545	0	ADP-ribosylation_factor_1	58,83	phospholipase_D1	14,30	ADP-ribosylation factor 1	phospholipase D1	375	5337	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of phospholipase_D1 by direct interaction with ADP-ribosylation_factor_1 and RalA .
22004728	0	ADP-ribosylation_factor_4	14,39	small_leucine_zipper_protein	54,82	ADP-ribosylation factor 4	small leucine zipper protein	378	10488	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of ADP-ribosylation_factor_4 expression by small_leucine_zipper_protein and involvement in breast_cancer cell migration .
10366714	0	ADP-ribosylation_factor_5	40,65	ARF5	67,71	ADP-ribosylation factor 5	ARF5	381	381	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the human ADP-ribosylation_factor_5 -LRB- ARF5 -RRB- gene .
9169151	0	ADP-ribosylation_factor_5	47,72	ARF5	74,78	ADP-ribosylation factor 5	ARF5	381	381	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization and characterization of the human ADP-ribosylation_factor_5 -LRB- ARF5 -RRB- gene .
14659046	0	ADP-ribosylation_factor_6	60,85	ARF6	87,91	ADP-ribosylation factor 6	ARF6	382	382	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence , genomic organization , and expression of the human ADP-ribosylation_factor_6 -LRB- ARF6 -RRB- gene : a class III ARF .
16413273	0	ADP-ribosylation_factor_6	68,93	EFA6A	20,25	ADP-ribosylation factor 6	EFA6A	382	5662	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Functional assay of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 -LRB- ARF6 -RRB- , in dendritic formation of hippocampal neurons .
24056087	0	ADP-ribosylation_factor_6	20,45	FE65	0,4	ADP-ribosylation factor 6	FE65	382	322	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FE65 interacts with ADP-ribosylation_factor_6 to promote neurite outgrowth .
10779358	0	ADP-ribosylation_factor_6	0,25	Rac1	87,91	ADP-ribosylation factor 6	Rac1	382	5879	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	ADP-ribosylation_factor_6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA .
14585928	0	ADP-ribosylation_factor_6	0,25	insulin	36,43	ADP-ribosylation factor 6	insulin	382	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	ADP-ribosylation_factor_6 regulates insulin secretion through plasma membrane phosphatidylinositol_4 ,5 - bisphosphate .
9671726	0	ADP-ribosylation_factor_domain_protein_1	16,56	ARD1	58,62	ADP-ribosylation factor domain protein 1	ARD1	373	373	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of ADP-ribosylation_factor_domain_protein_1 -LRB- ARD1 -RRB- in lysosomes and Golgi apparatus .
3146530	0	ADPRT	69,74	adenosine_diphosphate_ribosyl_transferase	26,67	ADPRT	adenosine diphosphate ribosyl transferase	142	142	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Hydrogen_peroxide induced adenosine_diphosphate_ribosyl_transferase -LRB- ADPRT -RRB- response in patients with inflammatory_bowel_disease .
2108672	0	ADPRT	59,64	adenosine_diphosphoribosyl_transferase	19,57	ADPRT	adenosine diphosphoribosyl transferase	142	142	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	The interaction of adenosine_diphosphoribosyl_transferase -LRB- ADPRT -RRB- with a cruciform DNA .
10608818	0	ADP_ribosylation_factor_1	20,45	Sec7	51,55	ADP ribosylation factor 1	Sec7	375	9267	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Dual interaction of ADP_ribosylation_factor_1 with Sec7 domain and with lipid membranes during catalysis of guanine_nucleotide exchange .
21825135	0	ADP_ribosylation_factor_6	0,25	amyloid_precursor_protein	42,67	ADP ribosylation factor 6	amyloid precursor protein	382	351	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	ADP_ribosylation_factor_6 -LRB- ARF6 -RRB- controls amyloid_precursor_protein -LRB- APP -RRB- processing by mediating the endosomal sorting of BACE1 .
27049325	0	ADRA2A	28,34	CDKAL1	36,42	ADRA2A	CDKAL1	150	54901	Gene	Gene	GRB10|appos|START_ENTITY GRB10|appos|END_ENTITY	Risk Alleles in/near ADCY5 , ADRA2A , CDKAL1 , CDKN2A/B , GRB10 , and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood : Results from the FAMILY Study .
27049325	0	ADRA2A	28,34	CDKN2A/B	44,52	ADRA2A	CDKN2A/B	150	1029;1030	Gene	Gene	GRB10|appos|START_ENTITY GRB10|appos|END_ENTITY	Risk Alleles in/near ADCY5 , ADRA2A , CDKAL1 , CDKN2A/B , GRB10 , and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood : Results from the FAMILY Study .
10909127	0	ADRA2A	59,65	adrenergic_alpha_2A_receptor	24,52	ADRA2A	adrenergic alpha 2A receptor	150	150	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the adrenergic_alpha_2A_receptor gene -LRB- ADRA2A -RRB- and measures of irritability , hostility , impulsivity and memory in normal subjects .
15900214	0	ADRA2B	51,57	alpha2B-adrenergic_receptor	17,44	ADRA2B	alpha2B-adrenergic receptor	151	151	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in the alpha2B-adrenergic_receptor gene -LRB- ADRA2B -RRB- and its relationship to vascular response in vivo .
25985706	0	ADRB2	10,15	adrenergic_receptor_b2	17,39	ADRB2	adrenergic receptor b2	154	154	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effect of ADRB2 -LRB- adrenergic_receptor_b2 -RRB- gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial_asthma .
17130852	0	ADRB2	38,43	beta-2_adrenoceptor	17,36	ADRB2	beta-2 adrenoceptor	154	154	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a beta-2_adrenoceptor -LRB- ADRB2 -RRB- gene variant with a blunted in vivo lipolysis and fat oxidation .
23653006	0	ADRB3	25,30	ADRB3	37,42	ADRB3	ADRB3	100294559(Tax:9940)	100294559(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Halplotypes of the ovine ADRB3 gene -LRB- ADRB3 -RRB- and their association with post-weaning growth in New Zealand Suffolk sheep .
23653006	0	ADRB3	37,42	ADRB3	25,30	ADRB3	ADRB3	100294559(Tax:9940)	100294559(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Halplotypes of the ovine ADRB3 gene -LRB- ADRB3 -RRB- and their association with post-weaning growth in New Zealand Suffolk sheep .
16272134	0	ADRP	55,59	adipose_differentiation-related_protein	14,53	ADRP	adipose differentiation-related protein	123	123	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of adipose_differentiation-related_protein -LRB- ADRP -RRB- is conjointly regulated by PU .1 and AP-1 in macrophages .
10623894	0	ADRP	56,60	adipose_differentiation_related_protein	15,54	ADRP	adipose differentiation related protein	123	123	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Stimulation of adipose_differentiation_related_protein -LRB- ADRP -RRB- expression in adipocyte precursors by long-chain fatty_acids .
9653655	0	ADTG	98,102	gamma-adaptin	78,91	ADTG	gamma-adaptin	164	164	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning , expression pattern , and chromosomal assignment to 16q23 of the human gamma-adaptin gene -LRB- ADTG -RRB- .
21868574	0	ADTRP	14,19	TFPI	30,34	ADTRP	TFPI	84830	7035	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen .
7506871	0	AE1	72,75	Anion_exchanger_1	0,17	AE1	Anion exchanger 1	6521	6521	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Anion_exchanger_1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus .
19565014	0	AE1	105,108	SLC4A1	97,103	AE1	SLC4A1	6521	6521	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Molecular mechanisms of autosomal dominant and recessive distal_renal_tubular_acidosis caused by SLC4A1 -LRB- AE1 -RRB- mutations .
20068363	0	AE1	103,106	SLC4A1	95,101	AE1	SLC4A1	6521	6521	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Distal_renal_tubular_acidosis in Filipino children , caused by mutations of the anion-exchanger SLC4A1 -LRB- AE1 , Band 3 -RRB- gene .
14575719	0	AE2	32,35	SLC4A2	58,64	AE2	SLC4A2	6522	6522	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	HNF1alpha upregulates the human AE2 anion exchanger gene -LRB- SLC4A2 -RRB- from an alternate promoter .
12592704	0	AE3	68,71	anion_exchanger_3	49,66	AE3	anion exchanger 3	20536(Tax:10090)	20536(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic cloning and promoter analysis of a mouse anion_exchanger_3 -LRB- AE3 -RRB- gene .
16159312	0	AE4	63,66	Foxi1	34,39	AE4	Foxi1	240215(Tax:10090)	14233(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	The forkhead transcription factor Foxi1 directly activates the AE4 promoter .
25824750	0	AEG-1	45,50	Astrocyte_Elevated_Gene-1	18,43	AEG-1	Astrocyte Elevated Gene-1	92140	92140	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Astrocyte_Elevated_Gene-1 -LRB- AEG-1 -RRB- in Cervical_Cancer and its Correlation with Angiogenesis .
25987128	0	AEG-1	87,92	EFEMP1	0,6	AEG-1	EFEMP1	92140	2202	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-kB signaling pathway .
22967897	0	AEG-1	56,61	MiR-136	0,7	AEG-1	MiR-136	92140	406927	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2 .
22041583	0	AEG-1	67,72	astrocyte-elevated_gene-1	40,65	AEG-1	astrocyte-elevated gene-1	92140	92140	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Exposure to cadmium_chloride influences astrocyte-elevated_gene-1 -LRB- AEG-1 -RRB- expression in MDA-MB231 human breast_cancer cells .
24989027	0	AEG-1	41,46	astrocyte_elevated_gene-1	14,39	AEG-1	astrocyte elevated gene-1	92140	92140	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- as a biomarker for aggressive pancreatic_ductal_adenocarcinoma .
25182604	0	AEG-1	41,46	astrocyte_elevated_gene-1	14,39	AEG-1	astrocyte elevated gene-1	92140	92140	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- in human meningiomas and its roles in cell proliferation and survival .
26823698	0	AEG-1	67,72	microRNA-377	0,12	AEG-1	microRNA-377	92140	494326	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	microRNA-377 inhibits non-small-cell lung_cancer through targeting AEG-1 .
25125681	0	AEG-1	0,5	retinoid_X_receptor	16,35	AEG-1	retinoid X receptor	92140	6256	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	AEG-1 regulates retinoid_X_receptor and inhibits retinoid signaling .
11548595	0	AEP	78,81	P300	60,64	AEP	P300	5641	2033	Gene	Gene	component|nmod|START_ENTITY component|compound|END_ENTITY	-LSB- Characteristics of the spatio-temporal organization of the P300 component of AEP during the `` active '' and `` passive '' stimulus perception in healthy subjects -RSB- .
12709428	0	AF-1	4,8	NOR-1	47,52	AF-1	NOR-1	3460	8013	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation , coactivator recruitment , and activation by the purine anti-metabolite 6-mercaptopurine .
23213263	0	AF-1	41,45	estrogen_receptor_a	58,77	AF-1	estrogen receptor a	19185(Tax:10090)	13982(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Transactivating function -LRB- AF -RRB- 2-mediated AF-1 activity of estrogen_receptor_a is crucial to maintain male reproductive tract function .
23580568	0	AF-1	4,8	estrogen_receptor_a	32,51	AF-1	estrogen receptor a	19185(Tax:10090)	13982(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	The AF-1 activation function of estrogen_receptor_a is necessary and sufficient for uterine epithelial cell proliferation in vivo .
25452582	0	AF-1	143,147	estrogen_receptor_a	69,88	AF-1	estrogen receptor a	3460	2099	Gene	Gene	domain|appos|START_ENTITY acts|nmod|domain acts|nmod|coactivator coactivator|compound|END_ENTITY	Retraction : ' A subfamily of RNA-binding DEAD-box proteins acts as an estrogen_receptor_a coactivator through the N-terminal activation domain -LRB- AF-1 -RRB- with an RNA coactivator , SRA ' .
11250900	0	AF-1	134,138	estrogen_receptor_alpha	56,79	AF-1	estrogen receptor alpha	3460	2099	Gene	Gene	domain|appos|START_ENTITY acts|nmod|domain acts|nmod|coactivator coactivator|compound|END_ENTITY	A subfamily of RNA-binding DEAD-box proteins acts as an estrogen_receptor_alpha coactivator through the N-terminal activation domain -LRB- AF-1 -RRB- with an RNA coactivator , SRA .
10976918	0	AF-1	4,8	retinoic_acid_receptor-alpha	40,68	AF-1	retinoic acid receptor-alpha	3460	5914	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	The AF-1 and AF-2 activating domains of retinoic_acid_receptor-alpha -LRB- RARalpha -RRB- and their phosphorylation are differentially involved in parietal endodermal differentiation of F9 cells and retinoid-induced expression of target genes .
8950979	0	AF-6	49,53	MLL	14,17	AF-6	MLL	4301	4297	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Fusion of the MLL gene with two different genes , AF-6 and AF-5alpha , by a complex translocation involving chromosomes 5 , 6 , 8 and 11 in infant_leukemia .
9348294	0	AF-6	15,19	ZO-1	35,39	AF-6	ZO-1	26955(Tax:10116)	292994(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells .
10567563	0	AF1	4,7	androgen_receptor	31,48	AF1	androgen receptor	3460	367	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	The AF1 and AF2 domains of the androgen_receptor interact with distinct regions of SRC1 .
15023052	0	AF1	33,36	androgen_receptor	44,61	AF1	androgen receptor	3460	367	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Induced alpha-helix structure in AF1 of the androgen_receptor upon binding transcription factor TFIIF .
15545613	0	AF1	86,89	glucocorticoid_receptor	62,85	AF1	glucocorticoid receptor	3460	2908	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	TATA_box_binding_protein induces structure in the recombinant glucocorticoid_receptor AF1 domain .
17655821	0	AF1	91,94	glucocorticoid_receptor	103,126	AF1	glucocorticoid receptor	3460	2908	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of different osmolytes on the induced folding of the N-terminal activation domain -LRB- AF1 -RRB- of the glucocorticoid_receptor .
21760925	0	AF1	59,62	glucocorticoid_receptor	35,58	AF1	glucocorticoid receptor	3460	2908	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	TBP binding-induced folding of the glucocorticoid_receptor AF1 domain facilitates its interaction with steroid_receptor_coactivator-1 .
22003412	0	AF1	38,41	glucocorticoid_receptor	72,95	AF1	glucocorticoid receptor	3460	2908	Gene	Gene	regulation|nmod|START_ENTITY transactivation|nsubj|regulation transactivation|dobj|domain domain|nmod|END_ENTITY	Binding-folding induced regulation of AF1 transactivation domain of the glucocorticoid_receptor by a cofactor that binds to its DNA binding domain .
11756182	0	AF10	23,27	GAS41	34,39	AF10	GAS41	8028	8089	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The MLL fusion partner AF10 binds GAS41 , a protein that interacts with the human SWI/SNF complex .
11423977	0	AF10	97,101	SYT	40,43	AF10	SYT	8028	6760	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The synovial_sarcoma associated protein SYT interacts with the acute_leukemia_associated_protein AF10 .
19864429	0	AF17	0,4	AF9	19,22	AF17	AF9	4302	4300	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na + channel alpha .
20007461	0	AF4	0,3	IGF-1	35,40	AF4	IGF-1	4299	3479	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development .
12885467	0	AF4	66,69	MLL-3	60,65	AF4	MLL-3	4299	58508	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Insertion of chromosome 11 in chromosome 4 resulting in a 5 ` MLL-3 ` AF4 fusion gene in a case of adult acute_lymphoblastic_leukemia .
12067721	0	AF6	37,40	Lmo2	23,27	AF6	Lmo2	4301	4005	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The LIM domain protein Lmo2 binds to AF6 , a translocation partner of the MLL oncogene .
19864429	0	AF9	19,22	AF17	0,4	AF9	AF17	4300	4302	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na + channel alpha .
11439343	0	AF9	41,44	MPc3	21,25	AF9	MPc3	70122(Tax:10090)	30951(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The polycomb protein MPc3 interacts with AF9 , an MLL fusion partner in t -LRB- 9 ; 11 -RRB- -LRB- p22 ; q23 -RRB- acute_leukemias .
21984596	0	AFAP	63,67	actin_filament-associated_protein	28,61	AFAP	actin filament-associated protein	70292(Tax:10090)	70292(Tax:10090)	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The actin-binding domain of actin_filament-associated_protein -LRB- AFAP -RRB- is involved in the regulation of cytoskeletal structure .
19540230	0	AFAP-110	14,22	Tks5	0,4	AFAP-110	Tks5	60312	9644	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Tks5 recruits AFAP-110 , p190RhoGAP , and cortactin for podosome formation .
22065534	0	AFF2	36,40	FMR2	42,46	AFF2	FMR2	2334	2481	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Microdeletion of Xq28 involving the AFF2 -LRB- FMR2 -RRB- gene in two unrelated males with developmental_delay .
7543018	0	AFP	19,22	Alpha-fetoprotein	0,17	AFP	Alpha-fetoprotein	24177(Tax:10116)	24177(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Alpha-fetoprotein -LRB- AFP -RRB- expression in clones of McA-RH 7777 rat hepatoma : correlation with the occurrence of homogeneously staining regions on chromosome 14 .
2426374	0	AFP	31,34	CA125	19,24	AFP	CA125	174	94025	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Analysis of serum CA125 , CEA , AFP , LDH levels and LDH isoenzymes in patients with ovarian_tumors -- correlation between tumor markers and histological types of ovarian_tumors -RSB- .
26976996	0	AFP	52,55	CEA	46,49	AFP	CEA	174	1084	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	Prognostic Value of Carcinoembryonic_Antigen -LRB- CEA -RRB- , AFP , CA19-9 and CA125 for Patients with Colorectal_Cancer with Peritoneal_Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy .
22087143	0	AFP	123,126	GPC3	128,132	AFP	GPC3	174	2719	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Clinical values of AFP , GPC3 mRNA in peripheral blood for prediction of hepatocellular_carcinoma recurrence following OLT : AFP , GPC3 mRNA for prediction of HCC .
15128351	0	AFP	53,56	alpha-fetoprotein	34,51	AFP	alpha-fetoprotein	174	174	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of elevated alpha-fetoprotein -LRB- AFP -RRB- in patients with chronic hepatitis_C , but not hepatocellular_carcinoma .
17433605	0	AFP	82,85	alpha-fetoprotein	63,80	AFP	alpha-fetoprotein	174	174	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein -LRB- AFP -RRB- gene and its significance in hepatocellular_carcinoma -LRB- HCC -RRB- .
18276085	0	AFP	25,28	alpha-fetoprotein	6,23	AFP	alpha-fetoprotein	174	174	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum alpha-fetoprotein -LRB- AFP -RRB- levels in breastfed infants with prolonged indirect hyperbilirubinemia .
18795704	0	AFP	53,56	alpha-fetoprotein	34,51	AFP	alpha-fetoprotein	174	174	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of elevated alpha-fetoprotein -LRB- AFP -RRB- in chronic hepatitis_C without hepatocellular_carcinoma .
23038230	0	AFP	46,49	alpha-fetoprotein	27,44	AFP	alpha-fetoprotein	174	174	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Variations in normal serum alpha-fetoprotein -LRB- AFP -RRB- levels in patients with testicular_cancer on surveillance .
6181482	0	AFP	27,30	alpha-fetoprotein	8,25	AFP	alpha-fetoprotein	24177(Tax:10116)	24177(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of alpha-fetoprotein -LRB- AFP -RRB- in the regulation of ovarian activity during hepatocarcinogenesis and post-natal development .
6188026	0	AFP	26,29	alpha-fetoprotein	7,24	AFP	alpha-fetoprotein	174	174	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Serum alpha-fetoprotein -LRB- AFP -RRB- levels in liver_cirrhosis and viral_hepatitis cases -RSB- .
7541181	0	AFP	55,58	alpha-fetoprotein	36,53	AFP	alpha-fetoprotein	174	174	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- A case of bladder_cancer producing alpha-fetoprotein -LRB- AFP -RRB- -RSB- .
9786226	0	AFP	44,47	alpha-fetoprotein	25,42	AFP	alpha-fetoprotein	174	174	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of maternal serum alpha-fetoprotein -LRB- AFP -RRB- in pregnant women and subsequent breast_cancer risk .
6203880	0	AFP	50,53	alpha-fetoprotin	32,48	AFP	alpha-fetoprotin	11576(Tax:10090)	11576(Tax:10090)	Gene	Gene	localisation|appos|START_ENTITY localisation|nmod|END_ENTITY	Ultrastructural localisation of alpha-fetoprotin -LRB- AFP -RRB- in regenerating mouse liver poisoned with CCL4 .
2454897	0	AFP	45,48	alpha_1-fetoprotein	24,43	AFP	alpha 1-fetoprotein	174	174	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Correlation between the alpha_1-fetoprotein -LRB- AFP -RRB- concentrations determined in the sera and in the tumour tissues in patients with testicular_tumours .
9556039	0	AFP	43,46	hCG	61,64	AFP	hCG	174	93659	Gene	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	The influence of smoking on maternal serum AFP and free beta hCG levels and the impact on screening for Down syndrome .
7983353	0	AG1	52,55	Dmp1	57,61	AG1	Dmp1	51060	1758	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	In situ localization and chromosomal mapping of the AG1 -LRB- Dmp1 -RRB- gene .
7743940	0	AGAMOUS	17,24	LEUNIG	0,6	AGAMOUS	LEUNIG	827631(Tax:3702)	829390(Tax:3702)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	LEUNIG regulates AGAMOUS expression in Arabidopsis flowers .
8103379	0	AGAMOUS	113,120	ZAG1	49,53	AGAMOUS	ZAG1	827631(Tax:3702)	542244(Tax:4577)	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Identification and molecular characterization of ZAG1 , the maize homolog of the Arabidopsis floral homeotic gene AGAMOUS .
16899218	0	AGAMOUS-LIKE_28	18,33	AGL28	35,40	AGAMOUS-LIKE 28	AGL28	837142(Tax:3702)	837142(Tax:3702)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of AGAMOUS-LIKE_28 -LRB- AGL28 -RRB- promotes flowering by upregulating expression of floral promoters within the autonomous pathway .
19318351	0	AGAP2	30,35	focal_adhesion_kinase	46,67	AGAP2	focal adhesion kinase	116986	5747	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Arf GTPase-activating protein AGAP2 regulates focal_adhesion_kinase activity and focal adhesion remodeling .
24098050	0	AGB1	77,81	AP-3	32,36	AGB1	AP-3	829597(Tax:3702)	824601(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Arabidopsis adaptor protein AP-3 interacts with the G-protein b subunit AGB1 and is involved in abscisic_acid regulation of germination and post-germination development .
21303978	0	AGBL2	69,74	RARRES1	17,24	AGBL2	RARRES1	79841	5918	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the a-tubulin tyrosination cycle .
18796298	0	AGER	71,75	advanced_glycosylation_end_product-specific_receptor	17,69	AGER	advanced glycosylation end product-specific receptor	177	177	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in advanced_glycosylation_end_product-specific_receptor -LRB- AGER -RRB- gene , insulin resistance , and type_2_diabetes_mellitus .
23383560	0	AGF	42,45	angiopoietin-related_growth_factor	6,40	AGF	angiopoietin-related growth factor	83854	83854	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum angiopoietin-related_growth_factor -LRB- AGF -RRB- levels are elevated_in_gestational_diabetes_mellitus and associated with insulin resistance .
19556247	0	AGGF1	56,61	GATA1	15,20	AGGF1	GATA1	55109	2623	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function .
1433976	0	AGIF	76,80	interleukin-11	54,68	AGIF	interleukin-11	3589	3589	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Function , molecular structure and gene expression of interleukin-11 -LRB- IL-11 / AGIF -RRB- -RSB- .
22415731	0	AGK	64,67	acylglycerol_kinase	43,62	AGK	acylglycerol kinase	55750	55750	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a truncation mutation of acylglycerol_kinase -LRB- AGK -RRB- gene in a novel autosomal recessive cataract locus .
22902690	0	AGL24	0,5	SOC1	27,31	AGL24	SOC1	828556(Tax:3702)	819174(Tax:3702)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	AGL24 acts in concert with SOC1 and FUL during Arabidopsis floral transition .
16899218	0	AGL28	35,40	AGAMOUS-LIKE_28	18,33	AGL28	AGAMOUS-LIKE 28	837142(Tax:3702)	837142(Tax:3702)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of AGAMOUS-LIKE_28 -LRB- AGL28 -RRB- promotes flowering by upregulating expression of floral promoters within the autonomous pathway .
18599653	0	AGL61	0,5	AGL80	21,26	AGL61	AGL80	817021(Tax:3702)	834925(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	AGL61 interacts with AGL80 and is required for central cell development in Arabidopsis .
18599653	0	AGL80	21,26	AGL61	0,5	AGL80	AGL61	834925(Tax:3702)	817021(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	AGL61 interacts with AGL80 and is required for central cell development in Arabidopsis .
26312837	0	AGO2	39,43	TP53	12,16	AGO2	TP53	27161	7157	Gene	Gene	loading|nmod|START_ENTITY role|acl|loading role|nmod|END_ENTITY	The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA-mRNA interaction network .
26701625	0	AGO2	38,42	TP53	0,4	AGO2	TP53	27161	7157	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network .
23712868	0	AGR2	0,4	HIF-1	32,37	AGR2	HIF-1	10551	3091	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	AGR2 expression is regulated by HIF-1 and contributes to growth and angiogenesis of glioblastoma .
18681322	0	AGR2	78,82	anterior_gradient-2	57,76	AGR2	anterior gradient-2	10551	10551	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|protein protein|amod|END_ENTITY	-LSB- Expression of a novel metastasis-inducing protein human anterior_gradient-2 -LRB- AGR2 -RRB- in breast_cancer and its clinical and prognostic significance -RSB- .
20945500	0	AGR2	25,29	anterior_gradient_2	4,23	AGR2	anterior gradient 2	10551	10551	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The anterior_gradient_2 -LRB- AGR2 -RRB- gene is overexpressed in prostate_cancer and may be useful as a urine sediment marker for prostate_cancer detection .
21451362	0	AGR3	33,37	anterior_gradient_homolog_3	4,31	AGR3	anterior gradient homolog 3	155465	155465	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The anterior_gradient_homolog_3 -LRB- AGR3 -RRB- gene is associated with differentiation and survival in ovarian_cancer .
10329427	0	AGRP	48,52	agouti-related_protein	24,46	AGRP	agouti-related protein	25582(Tax:10116)	25582(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in hypothalamic agouti-related_protein -LRB- AGRP -RRB- , but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats .
12668211	0	AGRP	56,60	agouti-related_protein	32,54	AGRP	agouti-related protein	181	181	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Elongation studies of the human agouti-related_protein -LRB- AGRP -RRB- core decapeptide -LRB- Yc -LSB- CRFFNAFC -RSB- Y -RRB- results in antagonism at the mouse melanocortin-3_receptor .
15193430	0	AGRP	53,57	agouti-related_protein	29,51	AGRP	agouti-related protein	11604(Tax:10090)	11604(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Down-regulated expression of agouti-related_protein -LRB- AGRP -RRB- mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice .
10329427	0	AGRP	48,52	alpha-MSH	63,72	AGRP	alpha-MSH	25582(Tax:10116)	24664(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in hypothalamic agouti-related_protein -LRB- AGRP -RRB- , but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats .
24307516	0	AGS3	47,51	activator_of_G-protein_signaling_3	11,45	AGS3	activator of G-protein signaling 3	26086	26086	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for activator_of_G-protein_signaling_3 -LRB- AGS3 -RRB- in multiple_myeloma .
11095476	0	AGT	62,65	AGT	77,80	AGT	AGT	183	183	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of the M235T polymorphism of human angiotensinogen -LRB- AGT -RRB- on plasma AGT and renin concentrations after ethinylestradiol administration .
11095476	0	AGT	77,80	AGT	62,65	AGT	AGT	183	183	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of the M235T polymorphism of human angiotensinogen -LRB- AGT -RRB- on plasma AGT and renin concentrations after ethinylestradiol administration .
11536039	0	AGT	62,65	O6-alkylguanine_DNA_alkyltransferase	24,60	AGT	O6-alkylguanine DNA alkyltransferase	17314(Tax:10090)	17314(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of human O6-alkylguanine_DNA_alkyltransferase -LRB- AGT -RRB- prevents MNU induced lymphomas in heterozygous p53 deficient mice .
12404103	0	AGT	50,53	angiotensinogen	33,48	AGT	angiotensinogen	183	183	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of putative functional angiotensinogen -LRB- AGT -RRB- gene variants controlling plasma AGT levels by combined segregation-linkage analysis .
15077204	0	AGT	76,79	angiotensinogen	54,69	AGT	angiotensinogen	183	183	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Natural selection and population history in the human angiotensinogen gene -LRB- AGT -RRB- : 736 complete AGT sequences in chromosomes from around the world .
23907112	0	AGT	73,76	angiotensinogen	56,71	AGT	angiotensinogen	183	183	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Simple renal_cysts and hypertension are associated with angiotensinogen -LRB- AGT -RRB- gene variant in Shiraz population -LRB- Iran -RRB- .
7607642	0	AGT	83,86	angiotensinogen	61,76	AGT	angiotensinogen	183	183	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection and characterization of new mutations in the human angiotensinogen gene -LRB- AGT -RRB- .
16949687	0	AGT	39,42	interferon-gamma	66,82	AGT	interferon-gamma	183	3458	Gene	Gene	transcription|appos|START_ENTITY transcription|nmod|END_ENTITY	Upregulation of human angiotensinogen -LRB- AGT -RRB- gene transcription by interferon-gamma : involvement of the STAT1-binding motif in the AGT promoter .
27050965	0	AGTR1	110,115	angiotensin_II_receptor_type_1	78,108	AGTR1	angiotensin II receptor type 1	185	185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of correlations between coronary_heart_disease and haplotypes of the angiotensin_II_receptor_type_1 -LRB- AGTR1 -RRB- gene .
23484035	0	AGTR1	81,86	angiotensin_II_type_1_receptor	49,79	AGTR1	angiotensin II type 1 receptor	185	185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Susceptibility and gene interaction study of the angiotensin_II_type_1_receptor -LRB- AGTR1 -RRB- gene polymorphisms with non-alcoholic_fatty_liver_disease in a multi-ethnic population .
21771600	0	AGTR1	38,43	miR-155	14,21	AGTR1	miR-155	185	406947	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	A polymorphic miR-155 binding site in AGTR1 is associated with cardiac_hypertrophy in Friedreich_ataxia .
18281495	0	AHA1	31,35	HSP90	13,18	AHA1	HSP90	10598	3320	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin .
21838297	0	AHAS	56,60	acetohydroxyacid_synthase	29,54	AHAS	acetohydroxyacid synthase	824015(Tax:3702)	824015(Tax:3702)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Chemical synthesis , in vitro acetohydroxyacid_synthase -LRB- AHAS -RRB- inhibition , herbicidal activity , and computational studies of isatin derivatives .
6685642	0	AHH	63,66	aryl-hydrocarbon_hydroxylase	33,61	AHH	aryl-hydrocarbon hydroxylase	1545	1545	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effect of cigarette smoke on aryl-hydrocarbon_hydroxylase -LRB- AHH -RRB- activity of the human kidney .
2295839	0	AHH	66,69	aryl_hydrocarbon_hydroxylase	36,64	AHH	aryl hydrocarbon hydroxylase	24296(Tax:10116)	24296(Tax:10116)	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of cytochrome_P-450-mediated aryl_hydrocarbon_hydroxylase -LRB- AHH -RRB- are higher in differentiated than in germinative cutaneous keratinocytes .
3619494	0	AHH	96,99	aryl_hydrocarbon_hydroxylase	66,94	AHH	aryl hydrocarbon hydroxylase	1545	1545	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of exposure to air pollution and smoking on the placental aryl_hydrocarbon_hydroxylase -LRB- AHH -RRB- activity .
6944164	0	AHH	46,49	aryl_hydrocarbon_hydroxylase	16,44	AHH	aryl hydrocarbon hydroxylase	1545	1545	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A twin study of aryl_hydrocarbon_hydroxylase -LRB- AHH -RRB- inducibility in cultured lymphocytes .
18936234	0	AHI-1	0,5	BCR-ABL	21,28	AHI-1	BCR-ABL	54806	25	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells .
23532844	0	AHI1	100,104	Abelson-helper_integration_site_1	65,98	AHI1	Abelson-helper integration site 1	52906(Tax:10090)	52906(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The Joubert_syndrome-associated missense mutation -LRB- V443D -RRB- in the Abelson-helper_integration_site_1 -LRB- AHI1 -RRB- protein alters its localization and protein-protein interactions .
20452750	0	AHI1	36,40	C6orf217	78,86	AHI1	C6orf217	54806	100131814	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Lymphoblast and brain expression of AHI1 and the novel primate-specific gene , C6orf217 , in schizophrenia and bipolar_disorder .
11312263	0	AHNAK	18,23	S100B	79,84	AHNAK	S100B	191572(Tax:10116)	25742(Tax:10116)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|protein protein|compound|END_ENTITY	The giant protein AHNAK is a specific target for the calcium - and zinc-binding S100B protein : potential implications for Ca2 + homeostasis regulation by S100B .
12588962	0	AHNAK	32,37	desmoyokin	39,49	AHNAK	desmoyokin	66395(Tax:10090)	66395(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the giant protein AHNAK -LRB- desmoyokin -RRB- in muscle and lining epithelial cells .
10619402	0	AHR	31,34	AHR	36,39	AHR	AHR	196	196	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|dep|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- heterodimer interacts with naturally occurring estrogen response elements .
10619402	0	AHR	36,39	AHR	31,34	AHR	AHR	196	196	Gene	Gene	aryl_hydrocarbon_receptor|dep|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- heterodimer interacts with naturally occurring estrogen response elements .
11368516	0	AHR	124,127	AHR	129,132	AHR	AHR	196	196	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|dep|translocator translocator|dep|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
11368516	0	AHR	129,132	AHR	124,127	AHR	AHR	196	196	Gene	Gene	translocator|dep|START_ENTITY aryl_hydrocarbon_receptor|dep|translocator aryl_hydrocarbon_receptor|appos|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
10048155	0	AHR	25,28	ARNT	30,34	AHR	ARNT	11622(Tax:10090)	11863(Tax:10090)	Gene	Gene	GR|compound|START_ENTITY GR|appos|END_ENTITY	RT-PCR quantification of AHR , ARNT , GR , and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone .
10619402	0	AHR	31,34	ARNT	62,66	AHR	ARNT	196	405	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY heterodimer|compound|aryl_hydrocarbon_receptor heterodimer|appos|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- heterodimer interacts with naturally occurring estrogen response elements .
10619402	0	AHR	36,39	ARNT	62,66	AHR	ARNT	196	405	Gene	Gene	aryl_hydrocarbon_receptor|dep|START_ENTITY heterodimer|compound|aryl_hydrocarbon_receptor heterodimer|appos|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- heterodimer interacts with naturally occurring estrogen response elements .
10728779	0	AHR	84,87	ARNT	119,123	AHR	ARNT	25690(Tax:10116)	25242(Tax:10116)	Gene	Gene	aromatic_hydrocarbon_receptor|appos|START_ENTITY aromatic_hydrocarbon_receptor|appos|END_ENTITY	Estrous cycle-dependent changes in the expression of aromatic_hydrocarbon_receptor -LRB- AHR -RRB- and AHR-nuclear translocator -LRB- ARNT -RRB- mRNAs in the rat ovary and liver .
11368516	0	AHR	124,127	ARNT	155,159	AHR	ARNT	196	405	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
11368516	0	AHR	129,132	ARNT	155,159	AHR	ARNT	196	405	Gene	Gene	translocator|dep|START_ENTITY aryl_hydrocarbon_receptor|dep|translocator aryl_hydrocarbon_receptor|appos|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
15114261	0	AHR	41,44	ARNT	98,102	AHR	ARNT	196	405	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AHR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- ARNT -RRB- mRNA expression in human spermatozoa .
16111922	0	AHR	36,39	ARNT	62,66	AHR	ARNT	196	405	Gene	Gene	translocator|compound|START_ENTITY translocator|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AHR -RRB- and AHR nuclear translocator -LRB- ARNT -RRB- expression in Baikal_seal -LRB- Pusa_sibirica -RRB- and association with 2,3,7,8-TCDD toxic equivalents and CYP1 expression levels .
9170146	0	AHR	19,22	Ah_receptor	6,17	AHR	Ah receptor	196	196	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human Ah_receptor -LRB- AHR -RRB- gene : localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility .
26208102	0	AHR	41,44	Aryl_Hydrocarbon_Receptor	14,39	AHR	Aryl Hydrocarbon Receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Deficiency in Aryl_Hydrocarbon_Receptor -LRB- AHR -RRB- Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells .
26208102	0	AHR	41,44	Aryl_Hydrocarbon_Receptor	14,39	AHR	Aryl Hydrocarbon Receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Deficiency in Aryl_Hydrocarbon_Receptor -LRB- AHR -RRB- Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells .
11090948	0	AHR	38,41	CYP1A1	3,9	AHR	CYP1A1	196	1543	Gene	Gene	related|nmod|START_ENTITY induction|acl|related induction|nsubj|END_ENTITY	Is CYP1A1 induction always related to AHR signaling pathway ?
11186136	0	AHR	109,112	CYP1A1	46,52	AHR	CYP1A1	196	1543	Gene	Gene	ARNT|compound|START_ENTITY polymorphisms|nmod|ARNT ascribable|nmod|polymorphisms ascribable|nsubj|phenotype phenotype|nmod|inducibility inducibility|nmod|END_ENTITY	An uncommon phenotype of poor inducibility of CYP1A1 in human lung is not ascribable to polymorphisms in the AHR , ARNT , or CYP1A1 genes .
23528250	0	AHR	54,57	CYP1A1	118,124	AHR	CYP1A1	196	1543	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Genetic association of aromatic_hydrocarbon receptor -LRB- AHR -RRB- and cytochrome_P450 , _ family_1 , subfamily_A , polypeptide_1 -LRB- CYP1A1 -RRB- polymorphisms with dioxin blood concentrations among pregnant Japanese women .
9170146	0	AHR	19,22	CYP1A1	99,105	AHR	CYP1A1	196	1543	Gene	Gene	gene|appos|START_ENTITY gene|nmod|inducibility inducibility|compound|END_ENTITY	Human Ah_receptor -LRB- AHR -RRB- gene : localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility .
17466352	0	AHR	58,61	CYP1A2	86,92	AHR	CYP1A2	11622(Tax:10090)	13077(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY uroporphyria|nmod|mice stimulates|dobj|uroporphyria stimulates|nmod|END_ENTITY	Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2 .
21490707	0	AHR	54,57	CYP1A2	70,76	AHR	CYP1A2	196	1544	Gene	Gene	7p21|appos|START_ENTITY 7p21|appos|END_ENTITY	Genome-wide meta-analysis identifies regions on 7p21 -LRB- AHR -RRB- and 15q24 -LRB- CYP1A2 -RRB- as determinants of habitual caffeine consumption .
9448724	0	AHR	114,117	Cyp1a1	76,82	AHR	Cyp1a1	11622(Tax:10090)	13076(Tax:10090)	Gene	Gene	transgenic_mice|appos|START_ENTITY gene|nmod|transgenic_mice gene|amod|END_ENTITY	The 4S benzo -LRB- a -RRB- pyrene-binding protein is not a transcriptional activator of Cyp1a1 gene in Ah_receptor-deficient -LRB- AHR - / - -RRB- transgenic_mice .
23208493	0	AHR	14,17	NF1C	35,39	AHR	NF1C	196	4782	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Inhibition of AHR transcription by NF1C is affected by a single-nucleotide polymorphism , and is involved in suppression of human_uterine_endometrial_cancer .
17171710	0	AHR	64,67	aromatic_hydrocarbon_receptor	33,62	AHR	aromatic hydrocarbon receptor	714254(Tax:9544)	714254(Tax:9544)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Autoradiographic localization of aromatic_hydrocarbon_receptor -LRB- AHR -RRB- in rhesus_monkey ovary .
19380484	0	AHR	52,55	aryl_hydrocarbon_receptor	25,50	AHR	aryl hydrocarbon receptor	196	196	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	The active form of human aryl_hydrocarbon_receptor -LRB- AHR -RRB- repressor lacks exon 8 , and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible_factor .
22211302	0	AHR	78,81	aryl_hydrocarbon_receptor	51,76	AHR	aryl hydrocarbon receptor	196	196	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The association of functional polymorphisms in the aryl_hydrocarbon_receptor -LRB- AHR -RRB- gene with the risk of vitiligo in Han Chinese populations .
22628113	0	AHR	52,55	aryl_hydrocarbon_receptor	25,50	AHR	aryl hydrocarbon receptor	196	196	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The evolving role of the aryl_hydrocarbon_receptor -LRB- AHR -RRB- in the normophysiology of hematopoiesis .
25718343	1	AHR	48,51	aryl_hydrocarbon_receptors	20,46	AHR	aryl hydrocarbon receptors	196	196	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of aryl_hydrocarbon_receptors -LRB- AHR -RRB- in the condition of experimental acute ileitis and administrations simvastatin and antagonist of receptors in interlekin-1 .
23624173	0	AHR2	49,53	CYP3A65	24,31	AHR2	CYP3A65	30517(Tax:7955)	553969(Tax:7955)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of zebrafish CYP3A65 transcription by AHR2 .
18000031	0	AHR_repressor	59,72	aryl_hydrocarbon_receptor	14,39	AHR repressor	aryl hydrocarbon receptor	57491	196	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|dep|signaling	Repression of aryl_hydrocarbon_receptor -LRB- AHR -RRB- signaling by AHR_repressor : role of DNA binding and competition for AHR nuclear translocator .
26476373	0	AHSG	40,44	Fetuin-A	30,38	AHSG	Fetuin-A	197	197	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	FGF23-regulated production of Fetuin-A -LRB- AHSG -RRB- in osteocytes .
15592877	0	AHSG	39,43	alpha2-HS_glycoprotein	15,37	AHSG	alpha2-HS glycoprotein	197	197	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of alpha2-HS_glycoprotein -LRB- AHSG , fetuin-A -RRB- polymorphism with AHSG and phosphate serum levels .
15589849	0	AHSG	65,69	alpha_2-Heremans_Schmidt_glycoprotein	26,63	AHSG	alpha 2-Heremans Schmidt glycoprotein	197	197	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between human alpha_2-Heremans_Schmidt_glycoprotein -LRB- AHSG -RRB- polymorphism and endometriosis in Korean women .
20627634	0	AHSP	50,54	alpha-hemoglobin-stabilizing_protein	12,48	AHSP	alpha-hemoglobin-stabilizing protein	51327	51327	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of alpha-hemoglobin-stabilizing_protein -LRB- AHSP -RRB- gene as a genetic modifier to the phenotype of beta-thalassemia in Southern China .
14715623	0	AHSP	52,56	alpha_hemoglobin_stabilizing_protein	14,50	AHSP	alpha hemoglobin stabilizing protein	51327	51327	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of alpha_hemoglobin_stabilizing_protein -LRB- AHSP -RRB- as a genetic modifier in patients with beta_thalassemia .
17874450	0	AHSP	65,69	alpha_hemoglobin_stabilizing_protein	27,63	AHSP	alpha hemoglobin stabilizing protein	51327	51327	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Population analysis of the alpha_hemoglobin_stabilizing_protein -LRB- AHSP -RRB- gene identifies sequence variants that alter expression and function .
21142933	0	AHSP	68,72	alpha_hemoglobin_stabilizing_protein	30,66	AHSP	alpha hemoglobin stabilizing protein	51327	51327	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A twins heritability study on alpha_hemoglobin_stabilizing_protein -LRB- AHSP -RRB- expression variability .
21292825	0	AIB1	8,12	ERa	43,46	AIB1	ERa	76960(Tax:10090)	13982(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|impacts impacts|dobj|effects effects|compound|END_ENTITY	Altered AIB1 or AIB1 / \ 3 expression impacts ERa effects on mammary gland stromal and epithelial content .
22550166	0	AIB1	0,4	ERa	5,8	AIB1	ERa	116833	2099	Gene	Gene	START_ENTITY|parataxis|enhanced enhanced|nsubjpass|activity activity|compound|END_ENTITY	AIB1 : ERa transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast_cancer cells .
23762395	0	AIB1	0,4	ERa	21,24	AIB1	ERa	63897	26284	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	AIB1 cooperates with ERa to promote epithelial mesenchymal transition in breast_cancer through SNAI1 activation .
18922467	0	AIB1	81,85	SRC-3	75,80	AIB1	SRC-3	8202	8202	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Essential phosphatases and a phospho-degron are critical for regulation of SRC-3 / AIB1 coactivator function and turnover .
18593949	0	AIB1	31,35	Steroid_receptor_coactivator-3	0,30	AIB1	Steroid receptor coactivator-3	8202	8202	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Steroid_receptor_coactivator-3 / AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression .
1730686	0	AIC2A	57,62	IL-3	34,38	AIC2A	IL-3	12984(Tax:10090)	16187(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Structure of mouse interleukin_3 -LRB- IL-3 -RRB- binding protein -LRB- AIC2A -RRB- .
18502715	0	AICAR	16,21	AMPK	0,4	AICAR	AMPK	471	5562	Gene	Gene	activator|appos|START_ENTITY activator|compound|END_ENTITY	AMPK activator , AICAR , inhibits palmitate-induced apoptosis in osteoblast .
24425763	0	AICAR	71,76	AMPK	32,36	AICAR	AMPK	471	5563	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Enhanced activation of cellular AMPK by dual-small molecule treatment : AICAR and A769662 .
15910743	0	AICAR	0,5	IL-2	17,21	AICAR	IL-2	471	3558	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells .
25058527	0	AICAR	0,5	Nrf2	14,18	AICAR	Nrf2	471	4780	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells .
23531513	0	AICAR	0,5	PPARy	15,20	AICAR	PPARy	471	5468	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	AICAR inhibits PPARy during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids .
20615388	0	AICAR	0,5	cyclooxygenase-2	14,30	AICAR	cyclooxygenase-2	471	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	AICAR induces cyclooxygenase-2 expression through AMP-activated_protein_kinase-transforming growth factor-beta-activated kinase 1-p38_mitogen-activated_protein_kinase signaling pathway .
15694368	0	AICAR	0,5	insulin_receptor	72,88	AICAR	insulin receptor	471	3643	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	AICAR , an activator of AMP-activated protein kinase , down-regulates the insulin_receptor expression in HepG2 cells .
21945951	0	AICAR	53,58	p53	22,25	AICAR	p53	471	7157	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases .
16005067	0	AICDA	102,107	activation-induced_cytidine_deaminase	63,100	AICDA	activation-induced cytidine deaminase	11628(Tax:10090)	11628(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a ubiquitously active promoter of the murine activation-induced_cytidine_deaminase -LRB- AICDA -RRB- gene .
2557706	0	AICE	70,74	angiotensin_I_converting_enzyme	37,68	AICE	angiotensin I converting enzyme	610668(Tax:9615)	610668(Tax:9615)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Effect of paraquat on serum and lung angiotensin_I_converting_enzyme -LRB- AICE -RRB- activity in beagle_dogs .
14990977	0	AID	93,96	Activation-induced_cytidine_deaminase	0,37	AID	Activation-induced cytidine deaminase	57379	57379	Gene	Gene	expression|compound|START_ENTITY association|nmod|expression expression|dep|association expression|amod|END_ENTITY	Activation-induced_cytidine_deaminase expression in follicular_lymphoma : association between AID expression and ongoing mutation in FL .
26585164	0	AID	44,47	Activation_Induced_Deaminase	14,42	AID	Activation Induced Deaminase	57379	57379	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Activation_Induced_Deaminase -LRB- AID -RRB- by Estrogen .
21169521	0	AID	32,35	BAFF	19,23	AID	BAFF	11628(Tax:10090)	24099(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP -1 pathways .
23166356	0	AID	26,29	BCL6	0,4	AID	BCL6	57379	604	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	BCL6 positively regulates AID and germinal center gene expression via repression of miR-155 .
23476051	0	AID	31,34	BCL6	0,4	AID	BCL6	57379	604	Gene	Gene	motifs|compound|START_ENTITY occur|nmod|motifs occur|nsubj|breaks breaks|compound|END_ENTITY	BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements .
23178148	0	AID	52,55	HoxC4	32,37	AID	HoxC4	11628(Tax:10090)	15423(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	APRIL stimulates NF-kB-mediated HoxC4 induction for AID expression in mouse B cells .
21186367	0	AID	67,70	PTBP2	23,28	AID	PTBP2	57379	58155	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA .
15273694	0	AID	37,40	Replication_protein_A	0,21	AID	Replication protein A	57379	6117	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Replication_protein_A interacts with AID to promote deamination of somatic hypermutation targets .
21804017	0	AID	0,3	UNG	13,16	AID	UNG	11628(Tax:10090)	22256(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus -LSB- corrected -RSB- .
10950930	0	AID	113,116	activation-induced_cytidine_deaminase	74,111	AID	activation-induced cytidine deaminase	57379	57379	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation , tissue distribution , and chromosomal localization of the human activation-induced_cytidine_deaminase -LRB- AID -RRB- gene .
14961036	0	AID	58,61	activation-induced_cytidine_deaminase	19,56	AID	activation-induced cytidine deaminase	57379	57379	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	High expression of activation-induced_cytidine_deaminase -LRB- AID -RRB- mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic_lymphocytic_leukaemia .
15732141	0	AID	66,69	activation-induced_cytidine_deaminase	27,64	AID	activation-induced cytidine deaminase	57379	57379	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of activation-induced_cytidine_deaminase -LRB- AID -RRB- in nodular lymphocyte-predominant and classical Hodgkin_lymphoma .
16574227	0	AID	61,64	activation-induced_cytidine_deaminase	22,59	AID	activation-induced cytidine deaminase	57379	57379	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Somatic mutations and activation-induced_cytidine_deaminase -LRB- AID -RRB- expression in established rheumatoid factor-producing lymphoblastoid cell line .
11847344	0	AID	49,52	activation-induced_deaminase	19,47	AID	activation-induced deaminase	418257(Tax:9031)	418257(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Requirement of the activation-induced_deaminase -LRB- AID -RRB- gene for immunoglobulin gene conversion .
25006166	0	AID	109,112	activation_induced_cytidine_deaminase	70,107	AID	activation induced cytidine deaminase	57379	57379	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Induction of homologous recombination between sequence repeats by the activation_induced_cytidine_deaminase -LRB- AID -RRB- protein .
16580072	0	AID	76,79	cytidine_deaminase	29,47	AID	cytidine deaminase	57379	978	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	HIV-1 Vif protein blocks the cytidine_deaminase activity of B-cell specific AID in E. _ coli by a similar mechanism of action .
18997814	0	AID	57,60	p53	81,84	AID	p53	11628(Tax:10090)	22059(Tax:10090)	Gene	Gene	triggered|nmod|START_ENTITY triggered|xcomp|causing causing|dobj|mutations mutations|compound|END_ENTITY	A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations .
26622562	0	AID	0,3	p53	5,8	AID	p53	57379	7157	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	AID , p53 and MLH1 expression in early gastric_neoplasms and the correlation with the background mucosa .
11311560	0	AIE-75	88,94	MCC2	15,19	AIE-75	MCC2	10083	83878	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of MCC2 , a novel homologue of MCC_tumor suppressor , with PDZ-domain Protein AIE-75 .
6178780	0	AIF	74,77	anti-invasion_factor	52,72	AIF	anti-invasion factor	280989(Tax:9913)	280989(Tax:9913)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural immunohistochemical localization of anti-invasion_factor -LRB- AIF -RRB- in bovine cartilage matrix .
17207087	0	AIF	74,77	apoptosis-inducing_factor	47,72	AIF	apoptosis-inducing factor	9131	9131	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Immunohistochemical and mutational analysis of apoptosis-inducing_factor -LRB- AIF -RRB- in colorectal_carcinomas .
24915960	0	AIF	45,48	apoptosis_inducing_factor	18,43	AIF	apoptosis inducing factor	26926(Tax:10090)	26926(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of apoptosis_inducing_factor -LRB- AIF -RRB- is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer 's _ disease .
15880691	0	AIF	94,97	p53	182,185	AIF	p53	9131	7157	Gene	Gene	apoptosis|appos|START_ENTITY apoptosis_inducing_factor|dobj|apoptosis leads|xcomp|apoptosis_inducing_factor leads|parataxis|mediated mediated|nsubj|lack lack|nmod|effect effect|nmod|ERK ERK|nmod|END_ENTITY	Inhibition of extracellular_signal_regulated_kinase -LRB- ERK -RRB- leads to apoptosis_inducing_factor -LRB- AIF -RRB- mediated apoptosis in epithelial breast_cancer cells : the lack of effect of ERK in p53 mediated copper induced apoptosis .
16729031	0	AIF	14,17	p53	32,35	AIF	p53	9131	7157	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of AIF expression by p53 .
23777936	0	AIF-1	94,99	COX-2	31,36	AIF-1	COX-2	199	5743	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Influence of Cyclooxygenase-2 -LRB- COX-2 -RRB- gene promoter-1195 and allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- polymorphisms on allograft outcome in Hispanic_kidney_transplant_recipients .
23777936	0	AIF-1	94,99	Cyclooxygenase-2	13,29	AIF-1	Cyclooxygenase-2	199	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Influence of Cyclooxygenase-2 -LRB- COX-2 -RRB- gene promoter-1195 and allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- polymorphisms on allograft outcome in Hispanic_kidney_transplant_recipients .
20850992	0	AIF-1	47,52	allograft_inflammatory_factor-1	14,45	AIF-1	allograft inflammatory factor-1	199	199	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- in acute cellular rejection of cardiac allografts .
12603318	1	AII	137,140	AII	84,87	AII	AII	183	183	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 .
12603318	1	AII	84,87	AII	137,140	AII	AII	183	183	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 .
1974420	0	AII	92,95	angiotensin_II	76,90	AII	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Binding and pharmacologic properties of peptides derived from human and rat angiotensin_II -LRB- AII -RRB- mRNA .
2998548	0	AII	40,43	angiotensin_II	24,38	AII	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of rat brain angiotensin_II -LRB- AII -RRB- receptors by intravenous AII and low dietary Na + .
24729378	0	AIM2	30,34	Absent_in_Melanoma_2	8,28	AIM2	Absent in Melanoma 2	9447	9447	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lack of Absent_in_Melanoma_2 -LRB- AIM2 -RRB- expression in tumor cells is closely associated with poor survival in colorectal_cancer patients .
26107252	0	AIM2	33,37	DNA-PK	77,83	AIM2	DNA-PK	383619(Tax:10090)	19090(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt .
26506473	0	AIM2	93,97	IL-1a	81,86	AIM2	IL-1a	9447	3552	Gene	Gene	Manner|compound|START_ENTITY END_ENTITY|nmod|Manner	Human Lung Cancer-Derived Immunosuppressive Plasmacytoid Dendritic Cells Release IL-1a in an AIM2 Inflammasome-Dependent Manner .
23530044	0	AIM2	39,43	absent_in_melanoma_2	17,37	AIM2	absent in melanoma 2	9447	9447	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Structure of the absent_in_melanoma_2 -LRB- AIM2 -RRB- pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly .
24701032	0	AIM2	0,4	caspase-1	116,125	AIM2	caspase-1	9447	834	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|regulating regulating|dobj|END_ENTITY	AIM2 mediates inflammation-associated renal_damage in hepatitis_B_virus-associated glomerulonephritis by regulating caspase-1 , IL-1b , and IL-18 .
25146391	0	AIMP1	0,5	PPARy	54,59	AIMP1	PPARy	9255	5468	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|dobj|END_ENTITY	AIMP1 negatively regulates adipogenesis by inhibiting PPARy .
20510162	0	AIMP1	106,111	gp96	73,77	AIMP1	gp96	9255	7184	Gene	Gene	phosphorylation|compound|START_ENTITY expression|nmod|phosphorylation expression|amod|END_ENTITY	Toll-like_receptor_4-mediated c-Jun_N-terminal_kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation .
16849534	0	AIMP3	0,5	p53	51,54	AIMP3	p53	9521	7157	Gene	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|activation activation|compound|END_ENTITY	AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability .
25643698	0	AIMP3	12,17	p53	63,66	AIMP3	p53	9521	7157	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Correction : AIMP3 Haploinsufficiency Disrupts Oncogene-Induced p53 Activation and Genomic Stability .
22402495	0	AIN-1	41,46	PAB-1	62,67	AIN-1	PAB-1	181719(Tax:6239)	172920(Tax:6239)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Caenorhabditis_elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes .
11025203	0	AINT	34,38	ARNT_interacting_protein	48,72	AINT	ARNT interacting protein	21335(Tax:10090)	21335(Tax:10090)	Gene	Gene	Isolation|nmod|START_ENTITY Isolation|dep|END_ENTITY	Isolation and characterization of AINT : a novel ARNT_interacting_protein expressed during murine embryonic development .
26054800	0	AINTEGUMENTA	12,24	SCABP8	75,81	AINTEGUMENTA	SCABP8	829931(Tax:3702)	829437(Tax:3702)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Arabidopsis AINTEGUMENTA -LRB- ANT -RRB- mediates salt tolerance by trans-repressing SCABP8 .
15270697	0	AIP	8,11	AIPL1	63,68	AIP	AIPL1	9049	23746	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of AIP and its homologue the blindness-associated protein AIPL1 in regulating client protein nuclear translocation .
21340166	0	AIP	118,121	ARYL_hydrocarbon_receptor_interacting_protein	71,116	AIP	ARYL hydrocarbon receptor interacting protein	9049	9049	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aggressive_prolactinoma in a child related to germline mutation in the ARYL_hydrocarbon_receptor_interacting_protein -LRB- AIP -RRB- gene .
25732638	0	AIP	112,115	Aryl_Hydrocarbon_Receptor_Interacting_Protein	65,110	AIP	Aryl Hydrocarbon Receptor Interacting Protein	9049	9049	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Familial Isolated Pituitary_Adenomas -LRB- FIPA -RRB- and Mutations in the Aryl_Hydrocarbon_Receptor_Interacting_Protein -LRB- AIP -RRB- Gene .
24366639	0	AIP	4,7	aryl_hydrocarbon_receptor-interacting_protein	9,54	AIP	aryl hydrocarbon receptor-interacting protein	9049	9049	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The AIP -LRB- aryl_hydrocarbon_receptor-interacting_protein -RRB- gene and its relation to the pathogenesis of pituitary_adenomas .
24996936	0	AIP	80,83	aryl_hydrocarbon_receptor-interacting_protein	33,78	AIP	aryl hydrocarbon receptor-interacting protein	9049	9049	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel germline mutation in the aryl_hydrocarbon_receptor-interacting_protein -LRB- AIP -RRB- gene in an Italian family with gigantism .
25614825	0	AIP	128,131	aryl_hydrocarbon_receptor-interacting_protein	81,126	AIP	aryl hydrocarbon receptor-interacting protein	9049	9049	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An unusual case of an ACTH-secreting macroadenoma with a germline variant in the aryl_hydrocarbon_receptor-interacting_protein -LRB- AIP -RRB- gene .
17242703	0	AIP	68,71	aryl_hydrocarbon_receptor_interacting_protein	21,66	AIP	aryl hydrocarbon receptor interacting protein	9049	9049	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of aryl_hydrocarbon_receptor_interacting_protein -LRB- AIP -RRB- gene in colorectal , breast , _ and_prostate_cancers .
20506337	0	AIP	67,70	aryl_hydrocarbon_receptor_interacting_protein	20,65	AIP	aryl hydrocarbon receptor interacting protein	9049	9049	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of aryl_hydrocarbon_receptor_interacting_protein -LRB- AIP -RRB- mutations in familial isolated pituitary_adenoma families .
18710468	0	AIP	108,111	p27	14,17	AIP	p27	9049	10671	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Assessment of p27 -LRB- cyclin-dependent kinase inhibitor 1B -RRB- and aryl_hydrocarbon_receptor-interacting_protein -LRB- AIP -RRB- genes in multiple_endocrine_neoplasia _ -LRB- MEN1 -RRB- _ syndrome patients without any detectable MEN1 gene mutations .
12813029	0	AIP1	0,4	ASK1	32,36	AIP1	ASK1	153090	4217	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 .
22899846	0	AIP1	0,4	cofilin	15,22	AIP1	cofilin	39505(Tax:7227)	37841(Tax:7227)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	AIP1 acts with cofilin to control actin dynamics during epithelial morphogenesis .
19580544	0	AIP4	116,120	spartin	11,18	AIP4	spartin	83737	23111	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Endogenous spartin -LRB- SPG20 -RRB- is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5 .
15270697	0	AIPL1	63,68	AIP	8,11	AIPL1	AIP	23746	9049	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of AIP and its homologue the blindness-associated protein AIPL1 in regulating client protein nuclear translocation .
25978041	0	AIRE	36,40	AIRE	4,8	AIRE	AIRE	326	326	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	The AIRE -230 Y Polymorphism Affects AIRE Transcriptional Activity : Potential Influence on AIRE Function in the Thymus .
25978041	0	AIRE	4,8	AIRE	36,40	AIRE	AIRE	326	326	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	The AIRE -230 Y Polymorphism Affects AIRE Transcriptional Activity : Potential Influence on AIRE Function in the Thymus .
22450362	0	AIRE	101,105	APECED	60,66	AIRE	APECED	326	326	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of two novel mutations in the first Sicilian APECED patient with no R203X mutation in AIRE gene and review of Italian APECED genotypes .
12398240	0	AIRE	22,26	Autoimmune_regulator	0,20	AIRE	Autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Autoimmune_regulator -LRB- AIRE -RRB- gene on chromosome 21 : implications for autoimmune_polyendocrinopathy-candidiasis-ectodermal_dystrophy -LRB- APECED -RRB- any more common manifestations of endocrine autoimmunity .
18083234	0	AIRE	26,30	PIAS1	36,41	AIRE	PIAS1	326	8554	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of AIRE with PIAS1 in transcriptional regulation .
11524731	0	AIRE	46,50	autoimmune_regulator	24,44	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	APECED mutations in the autoimmune_regulator -LRB- AIRE -RRB- gene .
11916620	0	AIRE	49,53	autoimmune_regulator	27,47	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutational analysis of the autoimmune_regulator -LRB- AIRE -RRB- gene in sporadic autoimmune Addison 's _ disease can reveal patients with unidentified autoimmune_polyendocrine_syndrome_type_I .
12542742	0	AIRE	34,38	autoimmune_regulator	12,32	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Role of the autoimmune_regulator -LRB- AIRE -RRB- gene in alopecia areata : strong association of a potentially functional AIRE polymorphism with alopecia_universalis .
16774540	0	AIRE	75,79	autoimmune_regulator	53,73	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Investigation of the p.Ser278Arg polymorphism of the autoimmune_regulator -LRB- AIRE -RRB- gene in alopecia_areata .
17590173	0	AIRE	41,45	autoimmune_regulator	14,34	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of autoimmune_regulator gene -LRB- AIRE -RRB- and T regulatory cells in human thymomas .
17891543	0	AIRE	211,215	autoimmune_regulator	184,204	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	An 8-year-old boy with autoimmune_hepatitis and Candida onychosis as the first symptoms of autoimmune_polyglandular_syndrome -LRB- APS1 -RRB- : identification of a new homozygous mutation in the autoimmune_regulator gene -LRB- AIRE -RRB- .
18616706	0	AIRE	40,44	autoimmune_regulator	18,38	AIRE	autoimmune regulator	326	326	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the autoimmune_regulator -LRB- AIRE -RRB- gene mutations in a cohort of Italian patients with autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy -LRB- APECED -RRB- and in their relatives .
18616774	0	AIRE	31,35	autoimmune_regulator	4,24	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The autoimmune_regulator gene -LRB- AIRE -RRB- is strongly associated with vitiligo .
20850570	0	AIRE	84,88	autoimmune_regulator	62,82	AIRE	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Recent insights into the role and molecular mechanisms of the autoimmune_regulator -LRB- AIRE -RRB- gene in autoimmunity .
23954874	0	AIRE	42,46	autoimmune_regulator	20,40	AIRE	autoimmune regulator	326	326	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human autoimmune_regulator -LRB- AIRE -RRB- gene translation by miR-220b .
19124002	0	AIRE	10,14	p63	31,34	AIRE	p63	326	8626	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells .
10720083	0	AIRE1	53,58	autoimmune_regulator	31,51	AIRE1	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A heterozygous deletion of the autoimmune_regulator -LRB- AIRE1 -RRB- gene , autoimmune_thyroid_disease , and type 1 diabetes : no evidence for association .
10996078	0	AIRK2	39,44	INCENP	0,6	AIRK2	INCENP	398457(Tax:8355)	3619	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes , the central spindle and cleavage furrow .
18347060	0	AJUBA	16,21	protein_arginine_methyltransferase_5	31,67	AJUBA	protein arginine methyltransferase 5	16475(Tax:10090)	27374(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|END_ENTITY	The LIM protein AJUBA recruits protein_arginine_methyltransferase_5 to mediate SNAIL-dependent transcriptional repression .
25312940	0	AK-1	0,4	SIRT2	17,22	AK-1	SIRT2	203	22933	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	AK-1 , a specific SIRT2 inhibitor , induces cell cycle arrest by downregulating Snail in HCT116 human colon_carcinoma cells .
26808575	0	AK-1	0,4	SIRT2	8,13	AK-1	SIRT2	203	22933	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	AK-1 , a SIRT2 inhibitor , destabilizes HIF-1a and diminishes its transcriptional activity during hypoxia .
11418133	0	AK-5	40,44	Bcl-2	79,84	AK-5	Bcl-2	301115(Tax:10116)	24224(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Differential regulation of apoptosis in AK-5 tumor cells by the proto-oncogene Bcl-2 : presence of Bcl-2 dependent and independent pathways .
11418133	0	AK-5	40,44	Bcl-2	98,103	AK-5	Bcl-2	301115(Tax:10116)	24224(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells regulation|nmod|apoptosis regulation|dep|presence presence|nmod|pathways pathways|amod|END_ENTITY	Differential regulation of apoptosis in AK-5 tumor cells by the proto-oncogene Bcl-2 : presence of Bcl-2 dependent and independent pathways .
11598802	0	AK-5	26,30	Bcl-2	127,132	AK-5	Bcl-2	301115(Tax:10116)	24224(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells Induction|nmod|apoptosis cytochrome|nsubj|Induction cytochrome|dobj|release release|nmod|END_ENTITY	Induction of apoptosis in AK-5 tumor cells by a serum factor from tumor rejecting animals : cytochrome c release independent of Bcl-2 and caspases .
17131910	0	AK-5	57,61	Bcl-2	95,100	AK-5	Bcl-2	301115(Tax:10116)	24224(Tax:10116)	Gene	Gene	tumor|compound|START_ENTITY derived|nmod|tumor cells|acl|derived induced|nmod|cells Heat_stress|acl|induced involves|nsubj|Heat_stress involves|dobj|downregulation downregulation|nmod|END_ENTITY	Heat_stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species .
7743551	0	AK-5	0,4	IL-12	57,62	AK-5	IL-12	301115(Tax:10116)	64546(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	AK-5 tumor-induced expression of interleukin-12 : role of IL-12 in NK-mediated AK-5 regression .
27039663	0	AKAP-9	0,6	Cdc42_interacting_protein_4	60,87	AKAP-9	Cdc42 interacting protein 4	10142	9322	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	AKAP-9 promotes colorectal_cancer development by regulating Cdc42_interacting_protein_4 .
26887056	0	AKAP-9	37,43	MALAT1	20,26	AKAP-9	MALAT1	10142	378938	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal_cancer cells .
22731613	0	AKAP-Lbc	31,39	Hsp20	92,97	AKAP-Lbc	Hsp20	11214	126393	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser -LRB- 16 -RRB- .
19696020	0	AKAP-Lbc	65,73	LC3	27,30	AKAP-Lbc	LC3	11214	84557	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc .
22052684	0	AKAP12	50,56	A_kinase_anchor_protein_12	22,48	AKAP12	A kinase anchor protein 12	9590	9590	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the A_kinase_anchor_protein_12 -LRB- AKAP12 -RRB- gene as a candidate tumor suppressor of hepatocellular carcinoma .
18397319	0	AKAP12	0,6	protein_kinase_Czeta	82,102	AKAP12	protein kinase Czeta	9590	5590	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein_kinase_Czeta .
19008911	0	AKAP220	0,7	AQP2	25,29	AKAP220	AQP2	11215	359	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts .
12147701	0	AKAP220	27,34	GSK-3beta	76,85	AKAP220	GSK-3beta	11215	2932	Gene	Gene	binds|compound|START_ENTITY binds|nmod|END_ENTITY	A-kinase anchoring protein AKAP220 binds to glycogen_synthase_kinase-3beta -LRB- GSK-3beta -RRB- and mediates protein kinase A-dependent inhibition of GSK-3beta .
21240291	0	AKAP3	15,20	CABYR	0,5	AKAP3	CABYR	10566	26256	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath .
14569596	0	AKAP350	62,69	CLIC4	0,5	AKAP350	CLIC4	10142	25932	Gene	Gene	enriched|nmod|START_ENTITY enriched|nsubjpass|END_ENTITY	CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells .
20664520	0	AKAP79	59,65	RXFP1	52,57	AKAP79	RXFP1	9495	59350	Gene	Gene	complex|dep|START_ENTITY complex|compound|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
20664520	0	AKAP79	59,65	beta-arrestin_2	72,87	AKAP79	beta-arrestin 2	9495	409	Gene	Gene	complex|dep|START_ENTITY complex|amod|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
11279182	0	AKAP95	27,33	helicase	96,104	AKAP95	helicase	10270	164045	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase .
25697797	0	AKIN10	129,135	PETAL_LOSS	0,10	AKIN10	PETAL LOSS	821259(Tax:3702)	831757(Tax:3702)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	PETAL_LOSS , a trihelix transcription factor that represses growth in Arabidopsis_thaliana , binds the energy-sensing SnRK1 kinase AKIN10 .
25126080	0	AKR1B1	43,49	SLCO2A1	84,91	AKR1B1	SLCO2A1	231	6578	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of the prostaglandin_F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm_labor .
22329800	0	AKR1B10	46,53	Epidermal_growth_factor	0,23	AKR1B10	Epidermal growth factor	57016	1950	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces tumour marker AKR1B10 expression through activator_protein-1 signalling in hepatocellular_carcinoma cells .
22222635	0	AKR1B10	74,81	aldo-keto_reductase_family_1B10	41,72	AKR1B10	aldo-keto reductase family 1B10	57016	57016	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Overexpression and oncogenic function of aldo-keto_reductase_family_1B10 -LRB- AKR1B10 -RRB- in pancreatic_carcinoma .
24140838	0	AKR1B10	0,7	p53	37,40	AKR1B10	p53	57016	7157	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	AKR1B10 , a transcriptional target of p53 , is downregulated in colorectal_cancers associated with poor prognosis .
11145742	0	AKR1B7	242,248	aldose_reductase-like	214,235	AKR1B7	aldose reductase-like	11997(Tax:10090)	102642655	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SF-1 _ -LRB- steroidogenic_factor-1 -RRB- , C/EBPbeta -LRB- CCAAT/enhancer binding protein -RRB- , and ubiquitous transcription factors NF1 _ -LRB- nuclear_factor_1 -RRB- and Sp1 -LRB- selective_promoter_factor_1 -RRB- are required for regulation of the mouse aldose_reductase-like gene -LRB- AKR1B7 -RRB- expression in adrenocortical cells .
11306105	0	AKR1B7	79,85	mouse_vas_deferens_protein	51,77	AKR1B7	mouse vas deferens protein	11997(Tax:10090)	11997(Tax:10090)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Physiological functions and hormonal regulation of mouse_vas_deferens_protein -LRB- AKR1B7 -RRB- in steroidogenic tissues .
15494462	0	AKR1C1	65,71	20alpha-hydroxysteroid_dehydrogenase	27,63	AKR1C1	20alpha-hydroxysteroid dehydrogenase	1645	1645	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and activity of 20alpha-hydroxysteroid_dehydrogenase -LRB- AKR1C1 -RRB- in abdominal subcutaneous and omental adipose tissue in women .
20338228	0	AKR1C1	126,132	aldo-keto_reductase_1C1	101,124	AKR1C1	aldo-keto reductase 1C1	1645	1645	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The CCAAT box binding transcription factor , nuclear factor-Y -LRB- NF-Y -RRB- regulates transcription of human aldo-keto_reductase_1C1 -LRB- AKR1C1 -RRB- gene .
22014308	0	AKR1C1	54,60	aldo-keto_reductase_family_1_member_C1	14,52	AKR1C1	aldo-keto reductase family 1 member C1	733634(Tax:9823)	733634(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of aldo-keto_reductase_family_1_member_C1 -LRB- AKR1C1 -RRB- gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy .
24303814	0	AKR1C1	71,77	aldo-keto_reductase_family_1_member_C1	31,69	AKR1C1	aldo-keto reductase family 1 member C1	733634(Tax:9823)	733634(Tax:9823)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Flutamide influences placental aldo-keto_reductase_family_1_member_C1 -LRB- AKR1C1 -RRB- expression in pigs .
26308156	0	AKR1C3	37,43	aldo-keto_reductase_1C3	12,35	AKR1C3	aldo-keto reductase 1C3	8644	8644	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of aldo-keto_reductase_1C3 -LRB- AKR1C3 -RRB- - mediated prostaglandin_D2 -LRB- PGD2 -RRB- metabolism in keloids .
18024509	0	AKR1C4	58,64	alpha-hydroxysteroid_dehydrogenase	22,56	AKR1C4	alpha-hydroxysteroid dehydrogenase	1109	1109	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of human 3 alpha-hydroxysteroid_dehydrogenase -LRB- AKR1C4 -RRB- expression by the liver X receptor alpha .
23160874	0	AKR1D1	64,70	SRD5B1	56,62	AKR1D1	SRD5B1	6718	6718	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two neonatal cholestasis patients with mutations in the SRD5B1 -LRB- AKR1D1 -RRB- gene : diagnosis and bile_acid profiles during chenodeoxycholic_acid treatment .
20606012	0	AKT	50,53	AKT	67,70	AKT	AKT	207	207	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Protein_tyrosine_kinase_6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor .
20606012	0	AKT	67,70	AKT	50,53	AKT	AKT	207	207	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Protein_tyrosine_kinase_6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor .
22911820	0	AKT	14,17	AKT	52,55	AKT	AKT	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Inhibition of AKT with the orally active allosteric AKT inhibitor , MK-2206 , sensitizes endometrial_cancer cells to progestin .
22911820	0	AKT	52,55	AKT	14,17	AKT	AKT	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	Inhibition of AKT with the orally active allosteric AKT inhibitor , MK-2206 , sensitizes endometrial_cancer cells to progestin .
24795023	0	AKT	11,14	AKT	66,69	AKT	AKT	207	207	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	C-terminal AKT phosphorylation by CDK2-cyclin A or mTOR activates AKT .
24795023	0	AKT	66,69	AKT	11,14	AKT	AKT	207	207	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	C-terminal AKT phosphorylation by CDK2-cyclin A or mTOR activates AKT .
21163859	0	AKT	84,87	Acid_sphingomyelinase	0,21	AKT	Acid sphingomyelinase	11651(Tax:10090)	20597(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Acid_sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression .
20432460	0	AKT	12,15	Ack1	41,45	AKT	Ack1	207	10188	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Shepherding AKT and androgen_receptor by Ack1 tyrosine kinase .
20947498	0	AKT	61,64	Annexin_2	0,9	AKT	Annexin 2	207	302	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Annexin_2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity .
11010972	0	AKT	120,123	BCR/ABL	0,7	AKT	BCR/ABL	207	25	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol_3-Kinase / AKT pathway .
25611382	0	AKT	59,62	BMCC1	0,5	AKT	BMCC1	207	158471	Gene	Gene	activity|compound|START_ENTITY attenuates|dobj|activity attenuates|nsubj|END_ENTITY	BMCC1 , which is an interacting partner of BCL2 , attenuates AKT activity , accompanied by apoptosis .
10542266	0	AKT	81,84	BRCA1	37,42	AKT	BRCA1	207	672	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol_3-Kinase / AKT in breast_cancer cells .
23429328	0	AKT	20,23	CD40	8,12	AKT	CD40	207	958	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
25770423	0	AKT	66,69	COX-2	19,24	AKT	COX-2	207	4513	Gene	Gene	activation|compound|START_ENTITY antagonizes|dobj|activation antagonizes|nsubj|PTEN PTEN|nmod|inhibitors inhibitors|compound|END_ENTITY	Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization .
26437743	0	AKT	14,17	CSL	0,3	AKT	CSL	207	1444	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	CSL regulates AKT to mediate androgen independence in prostate_cancer progression .
25307974	0	AKT	55,58	Crk-like_adapter_protein	0,24	AKT	Crk-like adapter protein	207	1399	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Crk-like_adapter_protein is required for TGF-b-induced AKT and ERK-signaling pathway in epithelial_ovarian_carcinomas .
17209049	0	AKT	0,3	DARPP-32	72,80	AKT	DARPP-32	207	84152	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|induction induction|nmod|END_ENTITY	AKT and CDK5/p35 mediate brain-derived_neurotrophic_factor induction of DARPP-32 in medium size spiny neurons in vitro .
22131882	0	AKT	16,19	DNA-PK	0,6	AKT	DNA-PK	207	5591	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance .
23380710	0	AKT	0,3	ERG	22,25	AKT	ERG	207	2078	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL .
16984917	0	AKT	106,109	ERK	112,115	AKT	ERK	207	5594	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	A splice variant of CD99 increases motility and MMP-9 expression of human breast_cancer cells through the AKT - , ERK - , and JNK-dependent AP-1 activation signaling pathways .
21263216	0	AKT	32,35	ERK	14,17	AKT	ERK	207	5594	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks .
23567182	0	AKT	20,23	ERK	37,40	AKT	ERK	11651(Tax:10090)	26413(Tax:10090)	Gene	Gene	Compensation|nmod|START_ENTITY Compensation|acl|signaling signaling|nmod|END_ENTITY	Compensation of the AKT signaling by ERK signaling in transgenic_mice hearts overexpressing TRIM72 .
24117170	0	AKT	91,94	ERK	86,89	AKT	ERK	207	2048	Gene	Gene	STAT3|appos|START_ENTITY STAT3|compound|END_ENTITY	Differential expression and activation of epidermal growth factor receptor 1 -LRB- EGFR1 -RRB- , ERK , AKT , STAT3 , and TWIST1 in nonsmall_cell_lung_cancer -LRB- NSCLC -RRB- .
26643367	0	AKT	73,76	Erythropoietin	0,14	AKT	Erythropoietin	11651(Tax:10090)	13856(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY resistance|nmod|activation alleviates|dobj|resistance alleviates|nsubj|END_ENTITY	Erythropoietin alleviates hepatic insulin resistance via PPARy-dependent AKT activation .
15781459	0	AKT	77,80	FOXO3a	4,10	AKT	FOXO3a	11651(Tax:10090)	56484(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY downstream|nmod|signaling regulates|dobj|downstream regulates|nsubj|factor factor|amod|END_ENTITY	The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling .
22056317	0	AKT	87,90	Focal_adhesion_kinase	0,21	AKT	Focal adhesion kinase	11651(Tax:10090)	14083(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY activating|dobj|pathways governs|advcl|activating governs|nsubj|END_ENTITY	Focal_adhesion_kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways .
26310353	0	AKT	54,57	FoxO3a	98,104	AKT	FoxO3a	207	2309	Gene	Gene	cisplatin|nmod|START_ENTITY cisplatin|nmod|END_ENTITY	Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a .
23559492	0	AKT	20,23	G-CSF	0,5	AKT	G-CSF	207	1440	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	G-CSF activation of AKT is not sufficient to prolong neutrophil survival .
22565593	0	AKT	145,148	HIF-1a	104,110	AKT	HIF-1a	207	3091	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	RY10-4 , a novel anti-tumor compound , exhibited its anti-angiogenesis activity by down-regulation of the HIF-1a and inhibition phosphorylation of AKT and mTOR .
25561311	0	AKT	89,92	HIF-1a	82,88	AKT	HIF-1a	207	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Chlorogenic_acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1a / AKT pathway .
21932108	0	AKT	114,117	Hepatocyte_growth_factor	0,24	AKT	Hepatocyte growth factor	207	3082	Gene	Gene	relative|xcomp|START_ENTITY relative|nsubj|END_ENTITY	Hepatocyte_growth_factor promoting the proliferation of human eccrine sweat gland epithelial cells is relative to AKT signal channel and b-catenin .
25200832	0	AKT	19,22	Hsp27	49,54	AKT	Hsp27	207	3315	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Phosphorylation of AKT induced by phosphorylated Hsp27 confers the apoptosis-resistance in t-AUCB-treated glioblastoma cells in vitro .
21474915	0	AKT	38,41	IGF-1	52,57	AKT	IGF-1	207	3479	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Direct interaction of a-synuclein and AKT regulates IGF-1 signaling : implication of Parkinson_disease .
25237386	0	AKT	105,108	IL-1a	41,46	AKT	IL-1a	207	3552	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Seminal plasma induces the expression of IL-1a in normal and neoplastic cervical cells via EP2/EGFR/PI3K / AKT pathway .
20018868	0	AKT	51,54	IRS-1	44,49	AKT	IRS-1	207	3667	Gene	Gene	insulin|compound|START_ENTITY signaling|nsubj|insulin Regulation|parataxis|signaling Regulation|nmod|insulin_receptor_substrate_1 insulin_receptor_substrate_1|appos|END_ENTITY	Regulation of insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- / AKT kinase-mediated insulin signaling by O-Linked_beta-N-acetylglucosamine in 3T3-L1 adipocytes .
26084673	0	AKT	14,17	Id1	31,34	AKT	Id1	11651(Tax:10090)	15901(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of AKT signaling by Id1 controls t -LRB- 8 ; 21 -RRB- _ leukemia initiation and progression .
25896712	0	AKT	76,79	KLF5	0,4	AKT	KLF5	207	688	Gene	Gene	activation|compound|START_ENTITY inhibits|nmod|activation inhibits|nsubj|END_ENTITY	KLF5 inhibits angiogenesis in PTEN-deficient_prostate_cancer by attenuating AKT activation and subsequent HIF1a accumulation .
22185211	0	AKT	80,83	L-asparaginase	43,57	AKT	L-asparaginase	207	80150	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Curcumin potentiates antitumor activity of L-asparaginase via inhibition of the AKT signaling pathway in acute_lymphoblastic_leukemia .
25481090	0	AKT	95,98	MMP-9	65,70	AKT	MMP-9	207	4318	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells .
21394210	0	AKT	20,23	MYC	0,3	AKT	MYC	207	4609	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors .
16227402	0	AKT	54,57	Mammalian_target_of_rapamycin	0,29	AKT	Mammalian target of rapamycin	207	2475	Gene	Gene	kinase|compound|START_ENTITY activate|dobj|kinase activate|nsubj|inhibitors inhibitors|compound|END_ENTITY	Mammalian_target_of_rapamycin inhibitors activate the AKT kinase in multiple_myeloma cells by up-regulating the insulin-like growth factor receptor/insulin _ receptor_substrate-1 / phosphatidylinositol_3-kinase cascade .
20600851	0	AKT	79,82	Migration_Stimulating_Factor	0,28	AKT	Migration Stimulating Factor	207	2335	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	Migration_Stimulating_Factor -LRB- MSF -RRB- promotes fibroblast migration by inhibiting AKT .
21927028	0	AKT	68,71	Mucin_1	0,7	AKT	Mucin 1	207	4582	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Mucin_1 enhances the tumor angiogenic response by activation of the AKT signaling pathway .
23618343	0	AKT	0,3	N-cadherin	18,28	AKT	N-cadherin	207	1000	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development .
10485711	0	AKT	25,28	NF-kappaB	0,9	AKT	NF-kappaB	207	4790	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling .
20200230	0	AKT	59,62	PDK1	120,124	AKT	PDK1	207	5163	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|functions functions|nmod|END_ENTITY	Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2 .
20643654	0	AKT	98,101	PDK1	0,4	AKT	PDK1	207	5163	Gene	Gene	activation|compound|START_ENTITY enhances|dobj|activation enhances|nsubj|recruitment recruitment|compound|END_ENTITY	PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like_growth_factor-i-stimulated AKT activation and vascular smooth muscle cell survival .
22905719	0	AKT	25,28	PER2	10,14	AKT	PER2	207	8864	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Mammalian PER2 regulates AKT activation and DNA damage response .
25829425	0	AKT	86,89	PHLPP2	106,112	AKT	PHLPP2	207	23035	Gene	Gene	Suppression|compound|START_ENTITY Suppression|nmod|END_ENTITY	MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2 .
16574813	0	AKT	157,160	PI-3K	151,156	AKT	PI-3K	207	5293	Gene	Gene	progression|parataxis|START_ENTITY progression|nmod|END_ENTITY	Ganglioside_GM3 modulates tumor suppressor PTEN-mediated cell cycle progression -- transcriptional induction of p21 -LRB- WAF1 -RRB- and p27 -LRB- kip1 -RRB- by inhibition of PI-3K / AKT pathway .
21500175	0	AKT	6,9	PI-3K	0,5	AKT	PI-3K	207	5293	Gene	Gene	modulates|compound|START_ENTITY vascular|nsubj|modulates END_ENTITY|appos|vascular	PI-3K / AKT signal pathway modulates vascular smooth muscle cells migration under cyclic mechanical strain .
21035837	0	AKT	113,116	PI3K	107,111	AKT	PI3K	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|kinase kinase|appos|END_ENTITY	A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3 ' - kinase -LRB- PI3K -RRB- / AKT pathway in ovarian_cancer cells .
23408974	0	AKT	73,76	PI3K	40,44	AKT	PI3K	207	5290	Gene	Gene	responsible|nmod|START_ENTITY responsible|nsubj|alterations alterations|nmod|pathway pathway|compound|END_ENTITY	Multiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian_carcinoma .
23429328	0	AKT	20,23	PI3K	25,29	AKT	PI3K	207	5293	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
23814023	0	AKT	56,59	PI3K	19,23	AKT	PI3K	207	5293	Gene	Gene	activation|nsubj|START_ENTITY mitigates|xcomp|activation mitigates|nsubj|inhibition inhibition|nmod|END_ENTITY	Dual inhibition of PI3K and mTOR mitigates compensatory AKT activation and improves tamoxifen response in breast_cancer .
23867821	0	AKT	16,19	PI3K	71,75	AKT	PI3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|treatment treatment|nmod|cells cells|nmod|inhibitors inhibitors|nummod|END_ENTITY	Reactivation of AKT signaling following treatment of cancer cells with PI3K inhibitors attenuates their antitumor effects .
24425783	0	AKT	57,60	PI3K	26,30	AKT	PI3K	207	5293	Gene	Gene	independent|nmod|START_ENTITY signaling|appos|independent signaling|compound|END_ENTITY	BRAFV600E cooperates with PI3K signaling , independent of AKT , to regulate melanoma cell proliferation .
24482231	0	AKT	90,93	PI3K	84,88	AKT	PI3K	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY Cluster|parataxis|signaling Cluster|acl|regulated regulated|nmod|phosphatidylinositide_3-Kinase phosphatidylinositide_3-Kinase|appos|END_ENTITY	Cluster of differentiation 166 -LRB- CD166 -RRB- regulated by phosphatidylinositide_3-Kinase -LRB- PI3K -RRB- / AKT signaling to exert its anti-apoptotic role via yes-associated_protein -LRB- YAP -RRB- in liver_cancer .
25100567	0	AKT	29,32	PI3K	22,26	AKT	PI3K	207	5293	Gene	Gene	axis|nsubj|START_ENTITY axis|advcl|Targeting Targeting|dobj|PI3-kinase PI3-kinase|appos|END_ENTITY	Targeting PI3-kinase -LRB- PI3K -RRB- , AKT and mTOR axis in lymphoma .
25424831	0	AKT	0,3	PI3K	42,46	AKT	PI3K	207	5290	Gene	Gene	hyper-phosphorylation|compound|START_ENTITY associated|nsubj|hyper-phosphorylation associated|nmod|mutations mutations|nummod|END_ENTITY	AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic_malformation .
25900077	0	AKT	152,155	PI3K	146,150	AKT	PI3K	207	5293	Gene	Gene	Pathways|nsubj|START_ENTITY Tone|parataxis|Pathways Tone|nmod|Proliferation Proliferation|nmod|Phosphatidylinositol_3-Kinase Phosphatidylinositol_3-Kinase|appos|END_ENTITY	A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / AKT and the Mammalian_Target_of_Rapamycin -LRB- MTOR -RRB- Pathways .
26895380	0	AKT	59,62	PI3K	53,57	AKT	PI3K	207	5293	Gene	Gene	growth|dep|START_ENTITY coordinate|dep|growth coordinate|dobj|END_ENTITY	Upregulated WDR26 serves as a scaffold to coordinate PI3K / AKT pathway-driven breast_cancer cell growth , migration , and invasion .
11179472	0	AKT	46,49	PI_3-kinase	34,45	AKT	PI 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Ultraviolet irradiation activates PI_3-kinase / AKT survival pathway via EGF receptors in human skin in vivo .
14633703	0	AKT	135,138	PP1	93,96	AKT	PP1	207	5464	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|compound|END_ENTITY	The heat_shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast_cancer cells .
12869565	0	AKT	105,108	PTEN	58,62	AKT	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	cascades|compound|START_ENTITY regulate|dobj|cascades alter|xcomp|regulate alter|dobj|function function|nmod|END_ENTITY	Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol_3-kinase / AKT cascades .
17341655	0	AKT	20,23	PTEN	0,4	AKT	PTEN	207	5728	Gene	Gene	pathway|compound|START_ENTITY more|nmod|pathway END_ENTITY|appos|more	PTEN , more than the AKT pathway .
17924977	0	AKT	26,29	PTEN	94,98	AKT	PTEN	207	5728	Gene	Gene	activation|nmod|START_ENTITY occurs|nsubj|activation occurs|nmod|mutations mutations|compound|END_ENTITY	Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial_cancer and may be associated with favorable prognosiss .
18231751	0	AKT	70,73	PTEN	121,125	AKT	PTEN	207	5728	Gene	Gene	Reversal|nmod|START_ENTITY Reversal|nmod|gene gene|compound|END_ENTITY	Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian_cancer cell line by wild-type PTEN gene .
18374229	0	AKT	109,112	PTEN	15,19	AKT	PTEN	207	5728	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity arrest|nmod|regulation M|dep|arrest M|dep|enhances enhances|nsubj|Combination Combination|nmod|END_ENTITY	Combination of PTEN and gamma-ionizing radiation enhances cell death and G -LRB- 2 -RRB- / M arrest through regulation of AKT activity and p21 induction in non-small-cell_lung_cancer cells .
18831514	0	AKT	99,102	PTEN	15,19	AKT	PTEN	207	5728	Gene	Gene	signaling|nsubj|START_ENTITY Association|parataxis|signaling Association|nmod|methylation methylation|compound|END_ENTITY	Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol_3-kinase / AKT signaling pathway in thyroid_tumors .
18937284	0	AKT	58,61	PTEN	38,42	AKT	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast_cancer cells .
19225041	0	AKT	13,16	PTEN	92,96	AKT	PTEN	207	5728	Gene	Gene	phosphorylation|compound|START_ENTITY suppressed|nsubjpass|phosphorylation suppressed|nmod|increase increase|nmod|END_ENTITY	IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells .
20154081	0	AKT	42,45	PTEN	71,75	AKT	PTEN	207	5728	Gene	Gene	START_ENTITY|nmod|keratinocytes keratinocytes|nmod|suppression suppression|compound|END_ENTITY	Immunosuppressive cyclosporin_A activates AKT in keratinocytes through PTEN suppression : implications in skin_carcinogenesis .
20596030	0	AKT	104,107	PTEN	165,169	AKT	PTEN	207	5728	Gene	Gene	activations|nmod|START_ENTITY activations|acl|signaling signaling|nmod|silencing silencing|nmod|gene gene|compound|END_ENTITY	Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT , ERK and STAT5 signaling via epigenetic silencing of the PTEN gene .
21129241	0	AKT	40,43	PTEN	30,34	AKT	PTEN	207	5728	Gene	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	-LSB- Correlation of expression of PTEN with AKT phosphorylation level in leukemia cells -RSB- .
21953448	0	AKT	254,257	PTEN	159,163	AKT	PTEN	207	5728	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Hydrogen_sulfide and L-cysteine increase phosphatidylinositol_3 ,4,5 - trisphosphate -LRB- PIP3 -RRB- and glucose utilization by inhibiting phosphatase and tensin homolog -LRB- PTEN -RRB- protein and activating phosphoinositide_3-kinase -LRB- PI3K -RRB- / serine/threonine protein kinase -LRB- AKT -RRB- / protein kinase C / -LRB- PKC / -RRB- in 3T3l1 adipocytes .
22885155	0	AKT	63,66	PTEN	88,92	AKT	PTEN	207	5728	Gene	Gene	cells|nmod|START_ENTITY potential|nmod|cells enhances|dobj|potential enhances|advcl|targeting targeting|dobj|END_ENTITY	MiR-26a enhances metastasis potential of lung_cancer cells via AKT pathway by targeting PTEN .
23132328	0	AKT	166,169	PTEN	108,112	AKT	PTEN	207	5728	Gene	Gene	TBI|nmod|START_ENTITY protects|nmod|TBI protects|parataxis|protects protects|nmod|traumatic_brain_injury traumatic_brain_injury|nmod|modulation modulation|nmod|END_ENTITY	Scriptaid , a novel histone deacetylase inhibitor , protects against traumatic_brain_injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT .
23788636	0	AKT	26,29	PTEN	159,163	AKT	PTEN	207	5728	Gene	Gene	loop|compound|START_ENTITY loop|acl|dephosphorylation dephosphorylation|nmod|homolog homolog|appos|END_ENTITY	Notch1 receptor regulates AKT protein activation loop -LRB- Thr308 -RRB- dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog -LRB- PTEN -RRB- - null T-cell_acute_lymphoblastic_leukemia cells .
23856247	0	AKT	43,46	PTEN	16,20	AKT	PTEN	207	5728	Gene	Gene	signaling|compound|START_ENTITY augment|dobj|signaling targets|xcomp|augment targets|dobj|END_ENTITY	miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small_cell_lung_cancer .
24270425	0	AKT	0,3	PTEN	24,28	AKT	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY promotes|nsubj|activation promotes|xcomp|END_ENTITY	AKT activation promotes PTEN hamartoma_tumor_syndrome-associated cataract development .
25026288	0	AKT	85,88	PTEN	8,12	AKT	PTEN	207	5728	Gene	Gene	a|nmod|START_ENTITY modifying|dobj|a lipid|acl|modifying stabilizes|dobj|lipid stabilizes|nsubj|Loss Loss|nmod|END_ENTITY	Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A a via AKT in prostate_cancer cells .
25344626	0	AKT	122,125	PTEN	116,120	AKT	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	pathways|nsubj|START_ENTITY Regulation|parataxis|pathways Regulation|nmod|Notch Notch|appos|END_ENTITY	Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase_and_tensin_homologue -LRB- PTEN -RRB- / AKT pathways .
25770423	0	AKT	66,69	PTEN	11,15	AKT	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY antagonizes|dobj|activation antagonizes|nsubj|END_ENTITY	Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization .
25925379	0	AKT	17,20	PTEN	69,73	AKT	PTEN	207	5728	Gene	Gene	Pathway|compound|START_ENTITY Dysregulation|nmod|Pathway Dysregulation|nmod|Methylation Methylation|nmod|END_ENTITY	Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN .
25900077	0	AKT	152,155	Phosphatidylinositol_3-Kinase	115,144	AKT	Phosphatidylinositol 3-Kinase	207	5293	Gene	Gene	Pathways|nsubj|START_ENTITY Tone|parataxis|Pathways Tone|nmod|Proliferation Proliferation|nmod|END_ENTITY	A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / AKT and the Mammalian_Target_of_Rapamycin -LRB- MTOR -RRB- Pathways .
26855187	0	AKT	41,44	Phosphoinositide_3-Kinase	129,154	AKT	Phosphoinositide 3-Kinase	207	18708(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Expression Expression|nmod|Subunits Subunits|compound|END_ENTITY	C-Type_Lectin-Like_Receptor_2 Suppresses AKT Signaling and Invasive Activities of Gastric_Cancer Cells by Blocking Expression of Phosphoinositide_3-Kinase Subunits .
24522204	0	AKT	40,43	Prohibitin_2	0,12	AKT	Prohibitin 2	207	11331	Gene	Gene	substrate|compound|START_ENTITY represents|dobj|substrate represents|nsubj|END_ENTITY	Prohibitin_2 represents a novel nuclear AKT substrate during all-trans_retinoic_acid-induced differentiation of acute_promyelocytic_leukemia cells .
22683505	0	AKT	42,45	Rhes	27,31	AKT	Rhes	207	23551	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Striatum specific protein , Rhes regulates AKT pathway .
24116102	0	AKT	95,98	Sox2	0,4	AKT	Sox2	11651(Tax:10090)	20674(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY involves|dobj|signaling loop|acl:relcl|involves regulated|nmod|loop regulated|nsubjpass|expression expression|amod|END_ENTITY	Sox2 expression is regulated by a negative feedback loop in embryonic stem cells that involves AKT signaling and FoxO1 .
25749514	0	AKT	15,18	Sox2	122,126	AKT	Sox2	207	6657	Gene	Gene	inhibitor|compound|START_ENTITY DC120|appos|inhibitor suppresses|nsubj|DC120 suppresses|nmod|END_ENTITY	DC120 , a novel AKT inhibitor , preferentially suppresses nasopharyngeal_carcinoma cancer stem-like cells by downregulating Sox2 .
12869565	0	AKT	105,108	Src	0,3	AKT	Src	11651(Tax:10090)	20779(Tax:10090)	Gene	Gene	cascades|compound|START_ENTITY regulate|dobj|cascades alter|xcomp|regulate alter|nsubj|kinases kinases|compound|END_ENTITY	Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol_3-kinase / AKT cascades .
23338526	0	AKT	76,79	Src	18,21	AKT	Src	207	6714	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma .
12009899	0	AKT	79,82	TCL1	36,40	AKT	TCL1	207	8115	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane .
22119715	0	AKT	114,117	TGF-b	0,5	AKT	TGF-b	11651(Tax:10090)	21803(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY p21|nmod|pathway down-regulation|nmod|p21 promotes|nmod|down-regulation promotes|nsubj|END_ENTITY	TGF-b promotes proliferation of thyroid epithelial cells in IFN-y -LRB- - / - -RRB- mice by down-regulation of p21 and p27 via AKT pathway .
22706160	0	AKT	21,24	TGF-b	70,75	AKT	TGF-b	207	7040	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-b type I receptor .
24422998	0	AKT	53,56	THP-1	140,145	AKT	THP-1	207	2736	Gene	Gene	plasma|nsubj|START_ENTITY plasma|nmod|line line|compound|END_ENTITY	Kaposi_sarcoma associated herpesvirus -LRB- KSHV -RRB- induces AKT hyperphosphorylation , bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line .
22305890	0	AKT	95,98	TIMP-1	130,136	AKT	TIMP-1	207	7076	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Atorvastatin sensitizes human non-small cell lung_carcinomas to carboplatin via suppression of AKT activation and upregulation of TIMP-1 .
23936739	0	AKT	21,24	TMEFF2	0,6	AKT	TMEFF2	207	23671	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	TMEFF2 modulates the AKT and ERK signaling pathways .
17369395	0	AKT	14,17	TOR	38,41	AKT	AKT	41957(Tax:7227)	41957(Tax:7227)	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Re-evaluating AKT regulation : role of TOR complex 2 in tissue growth .
17721920	0	AKT	14,17	TP53	56,60	AKT	TP53	207	7157	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal_squamous_cell_carcinoma .
21625476	0	AKT	100,103	TRAIL-R4	0,8	AKT	TRAIL-R4	207	8793	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical_carcinoma HeLa cells through AKT .
17576771	0	AKT	84,87	TRB2	0,4	AKT	TRB2	11651(Tax:10090)	217410(Tax:10090)	Gene	Gene	inhibiting|dobj|START_ENTITY suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	TRB2 , a mouse Tribbles ortholog , suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta .
16740698	0	AKT	0,3	TSC2	65,69	AKT	TSC2	207	7249	Gene	Gene	activation|compound|START_ENTITY enhances|nsubj|activation enhances|dobj|proliferation proliferation|nmod|signaling signaling|compound|END_ENTITY	AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling .
12865424	0	AKT	115,118	Toll-like_receptor-4	25,45	AKT	Toll-like receptor-4	207	7099	Gene	Gene	START_ENTITY|nsubj|modulation modulation|nmod|END_ENTITY	Reciprocal modulation of Toll-like_receptor-4 signaling pathways involving MyD88 and phosphatidylinositol_3-kinase / AKT by saturated and polyunsaturated_fatty_acids .
19357198	0	AKT	78,81	Tsc2	24,28	AKT	Tsc2	207	7249	Gene	Gene	signaling|nmod|START_ENTITY highlights|advcl|signaling highlights|nsubj|allele allele|nmod|END_ENTITY	A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles .
22426999	0	AKT	15,18	USP1	0,4	AKT	USP1	207	7398	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung_cancer cells .
23429328	0	AKT	20,23	VEGF	14,18	AKT	VEGF	207	7422	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
19726736	0	AKT	0,3	XIAP	104,108	AKT	XIAP	207	331	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|expression expression|compound|END_ENTITY	AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression .
20632385	0	AKT	84,87	XIAP	27,31	AKT	XIAP	207	331	Gene	Gene	signalling|compound|START_ENTITY significance|nmod|signalling significance|nmod|expression expression|compound|END_ENTITY	Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling .
25775215	0	AKT	30,33	YY1	14,17	AKT	YY1	11651(Tax:10090)	22632(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	IL-13 Induces YY1 through the AKT Pathway in Lung Fibroblasts .
22057101	0	AKT	51,54	ZNRF1	0,5	AKT	ZNRF1	207	84937	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	ZNRF1 promotes Wallerian_degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation .
25831050	0	AKT	110,113	Zipper-interacting_protein_kinase	0,33	AKT	Zipper-interacting protein kinase	207	1613	Gene	Gene	signaling|compound|START_ENTITY promotes|nmod|signaling promotes|nsubj|END_ENTITY	Zipper-interacting_protein_kinase promotes epithelial-mesenchymal transition , invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric_cancer patients .
25646597	0	AKT	100,103	b-catenin	0,9	AKT	b-catenin	207	1499	Gene	Gene	interfering|nmod|START_ENTITY proliferation|acl|interfering inhibits|dobj|proliferation inhibits|nsubj|knockdown knockdown|amod|END_ENTITY	b-catenin knockdown inhibits pituitary_adenoma cell proliferation and invasion via interfering with AKT and gelatinases expression .
14576155	0	AKT	0,3	cyclin_D1	101,110	AKT	cyclin D1	207	595	Gene	Gene	activity|compound|START_ENTITY determines|nsubj|activity determines|advcl|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|advcl|regulating regulating|dobj|expression expression|amod|END_ENTITY	AKT activity determines sensitivity to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors by regulating cyclin_D1 and c-myc expression .
20959404	0	AKT	103,106	epidermal_growth_factor_receptor	40,72	AKT	epidermal growth factor receptor	207	1956	Gene	Gene	confers|nsubj|START_ENTITY phosphatidylinositol_3-kinase|appos|confers phosphatidylinositol_3-kinase|dep|upregulated upregulated|nmod|oncoprotein oncoprotein|nmod|END_ENTITY	cIAP2 upregulated by E6 oncoprotein via epidermal_growth_factor_receptor / phosphatidylinositol_3-kinase / AKT pathway confers resistance to cisplatin in human_papillomavirus_16 / 18-infected lung_cancer .
18694847	0	AKT	32,35	erythropoietin	81,95	AKT	erythropoietin	207	2056	Gene	Gene	translocation|nmod|START_ENTITY required|nsubjpass|translocation required|nmod|END_ENTITY	Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells .
24398676	0	AKT	0,3	ezrin	39,44	AKT	ezrin	207	7430	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex : role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking .
12242282	0	AKT	46,49	focal_adhesion_kinase	71,92	AKT	focal adhesion kinase	11651(Tax:10090)	14083(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY activates|dobj|pathway activates|advcl|utilizing utilizing|dobj|END_ENTITY	v-Crk activates the phosphoinositide_3-kinase / AKT pathway by utilizing focal_adhesion_kinase and H-Ras .
22948179	0	AKT	99,102	focal_adhesion_kinase	77,98	AKT	focal adhesion kinase	207	5747	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Sonic hedgehog signaling pathway induces cell migration and invasion through focal_adhesion_kinase / AKT signaling-mediated activation of matrix_metalloproteinase _ -LRB- MMP -RRB- -2 and MMP-9 in liver_cancer .
14576155	0	AKT	0,3	mTOR	70,74	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY determines|nsubj|activity determines|advcl|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|dobj|inhibitors inhibitors|appos|END_ENTITY	AKT activity determines sensitivity to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors by regulating cyclin_D1 and c-myc expression .
17016437	0	AKT	0,3	mTOR	38,42	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|nsubj|activity regulates|dobj|ability ability|nmod|inhibitors inhibitors|compound|END_ENTITY	AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple_myeloma cells .
17804710	0	AKT	115,118	mTOR	84,88	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY converge|advcl|activating converge|nmod|vivo vivo|nmod|kinase kinase|compound|END_ENTITY	Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT .
18826385	0	AKT	41,44	mTOR	47,51	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	PTEN|dep|START_ENTITY Expression|nmod|PTEN END_ENTITY|nsubj|Expression	Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas .
19120326	0	AKT	40,43	mTOR	15,19	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002 .
21168265	0	AKT	154,157	mTOR	52,56	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY suppressing|dobj|signaling enhances|advcl|suppressing enhances|dobj|activity activity|nmod|rapamycin rapamycin|compound|END_ENTITY	Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast_cancer cell lines mainly by suppressing rapamycin-induced AKT signaling .
21909130	0	AKT	0,3	mTOR	114,118	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|absence absence|dep|implications implications|acl|targeting targeting|dobj|END_ENTITY	AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage : implications for targeting mTOR during malignancy .
21993994	0	AKT	0,3	mTOR	177,181	AKT	mTOR	11651(Tax:10090)	21977(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|way way|nmod|END_ENTITY	AKT -LRB- v-akt murine thymoma viral oncogene homolog 1 -RRB- and N-Ras -LRB- neuroblastoma ras viral oncogene homolog -RRB- coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR -LRB- mammalian target of rapamycin complex 1 -RRB- , FOXM1 -LRB- forkhead_box_M1 -RRB- / SKP2 , and c-Myc pathways .
24131573	0	AKT	0,3	mTOR	59,63	AKT	mTOR	24185(Tax:10116)	21977(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia .
24705275	0	AKT	0,3	mTOR	75,79	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|xcomp|promote promote|advcl|signaling signaling|nsubj|disruption disruption|nmod|END_ENTITY	AKT inhibitors promote cell death in cervical_cancer through disruption of mTOR signaling and glucose uptake .
25710488	0	AKT	87,90	mTOR	47,51	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	Stimulators|compound|START_ENTITY Effects|nmod|Stimulators Promotion|dep|Effects Promotion|nmod|Growth Growth|nmod|Activation Activation|compound|END_ENTITY	Promotion of Ovarian Follicle Growth following mTOR Activation : Synergistic Effects of AKT Stimulators .
26535060	0	AKT	64,67	mTOR	30,34	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Targeting|nmod|Signaling Well|nmod|Targeting END_ENTITY|nmod|Well	Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular_Carcinoma .
26824321	0	AKT	68,71	mTOR	27,31	AKT	mTOR	207	21977(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY determines|nmod|inhibition determines|nsubj|regulation regulation|nmod|signaling signaling|compound|END_ENTITY	Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse_large_B_cell_lymphoma .
26130148	0	AKT	16,19	mTORC2	0,6	AKT	mTORC2	207	74343(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|amod|END_ENTITY	mTORC2 Balances AKT Activation and eIF2a Serine 51 Phosphorylation to Promote Survival under Stress .
14576155	0	AKT	0,3	mammalian_target_of_rapamycin	39,68	AKT	mammalian target of rapamycin	207	2475	Gene	Gene	activity|compound|START_ENTITY determines|nsubj|activity determines|advcl|END_ENTITY	AKT activity determines sensitivity to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors by regulating cyclin_D1 and c-myc expression .
20351317	0	AKT	122,125	mammalian_target_of_rapamycin	31,60	AKT	mammalian target of rapamycin	207	2475	Gene	Gene	pathways|nmod|START_ENTITY cells|nmod|pathways signaling|nmod|cells END_ENTITY|xcomp|signaling	Luteinizing hormone stimulates mammalian_target_of_rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase : modulation of glycogen synthase kinase 3 and AMP-activated protein kinase .
23856247	0	AKT	43,46	miR-205	0,7	AKT	miR-205	207	406988	Gene	Gene	signaling|compound|START_ENTITY augment|dobj|signaling targets|xcomp|augment targets|nsubj|END_ENTITY	miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small_cell_lung_cancer .
26446417	0	AKT	64,67	miR-205	0,7	AKT	miR-205	207	406988	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-205 promotes epithelial-mesenchymal transition by targeting AKT signaling in endometrial_cancer cells .
12458207	0	AKT	66,69	mixed_lineage_kinase_3	23,45	AKT	mixed lineage kinase 3	207	4296	Gene	Gene	leads|nsubj|START_ENTITY regulation|parataxis|leads regulation|nmod|END_ENTITY	Negative regulation of mixed_lineage_kinase_3 by protein_kinase_B / AKT leads to cell survival .
13679862	0	AKT	204,207	p21	167,170	AKT	p21	207	1026	Gene	Gene	inhibition|compound|START_ENTITY induction|nmod|inhibition induction|amod|END_ENTITY	Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21 -LRB- CIP1/WAF1 -RRB- induction rather than AKT inhibition .
16574813	0	AKT	157,160	p21	110,113	AKT	p21	207	1026	Gene	Gene	progression|parataxis|START_ENTITY progression|dep|induction induction|nmod|END_ENTITY	Ganglioside_GM3 modulates tumor suppressor PTEN-mediated cell cycle progression -- transcriptional induction of p21 -LRB- WAF1 -RRB- and p27 -LRB- kip1 -RRB- by inhibition of PI-3K / AKT pathway .
22119715	0	AKT	114,117	p21	98,101	AKT	p21	11651(Tax:10090)	12575(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	TGF-b promotes proliferation of thyroid epithelial cells in IFN-y -LRB- - / - -RRB- mice by down-regulation of p21 and p27 via AKT pathway .
11605009	0	AKT	79,82	p38	17,20	AKT	p38	207	1432	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway regulates|dobj|activation regulates|nsubj|feedback feedback|amod|END_ENTITY	Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes .
16475687	0	AKT	74,77	p38	47,50	AKT	p38	207	5594	Gene	Gene	activation|compound|START_ENTITY MAPK|nmod|activation MAPK|amod|END_ENTITY	Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon_cancer cells .
20922461	0	AKT	35,38	phosphatidyl_inositol_3-kinase	4,34	AKT	phosphatidyl inositol 3-kinase	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	The phosphatidyl_inositol_3-kinase / AKT signaling pathway in breast_cancer .
11010972	0	AKT	120,123	phosphatidylinositol_3-Kinase	90,119	AKT	phosphatidylinositol 3-Kinase	207	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol_3-Kinase / AKT pathway .
11034077	0	AKT	34,37	phosphatidylinositol_3-kinase	4,33	AKT	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	transduction|compound|START_ENTITY transduction|amod|END_ENTITY	The phosphatidylinositol_3-kinase / AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel .
11118064	0	AKT	34,37	phosphatidylinositol_3-kinase	4,33	AKT	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	The phosphatidylinositol_3-kinase / AKT kinase pathway in multiple_myeloma plasma cells : roles in cytokine-dependent survival and proliferative responses .
12869565	0	AKT	105,108	phosphatidylinositol_3-kinase	75,104	AKT	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	cascades|compound|START_ENTITY cascades|amod|END_ENTITY	Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol_3-kinase / AKT cascades .
16014629	0	AKT	50,53	phosphatidylinositol_3-kinase	20,49	AKT	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|dep|END_ENTITY	Presenilins mediate phosphatidylinositol_3-kinase / AKT and ERK activation via select signaling receptors .
16227402	0	AKT	54,57	phosphatidylinositol_3-kinase	177,206	AKT	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	kinase|compound|START_ENTITY activate|dobj|kinase activate|advcl|up-regulating up-regulating|xcomp|/ /|dobj|cascade cascade|amod|END_ENTITY	Mammalian_target_of_rapamycin inhibitors activate the AKT kinase in multiple_myeloma cells by up-regulating the insulin-like growth factor receptor/insulin _ receptor_substrate-1 / phosphatidylinositol_3-kinase cascade .
18831514	0	AKT	99,102	phosphatidylinositol_3-kinase	69,98	AKT	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	signaling|nsubj|START_ENTITY Association|parataxis|signaling Association|nmod|alterations alterations|nmod|END_ENTITY	Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol_3-kinase / AKT signaling pathway in thyroid_tumors .
20959404	0	AKT	103,106	phosphatidylinositol_3-kinase	73,102	AKT	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	confers|nsubj|START_ENTITY END_ENTITY|appos|confers	cIAP2 upregulated by E6 oncoprotein via epidermal_growth_factor_receptor / phosphatidylinositol_3-kinase / AKT pathway confers resistance to cisplatin in human_papillomavirus_16 / 18-infected lung_cancer .
21042767	0	AKT	54,57	phosphatidylinositol_3-kinase	24,53	AKT	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY leads|nsubj|pathway Inhibition|parataxis|leads Inhibition|nmod|END_ENTITY	Inhibition of activated phosphatidylinositol_3-kinase / AKT pathway in malignant_pleural_mesothelioma leads to G1 cell cycle arrest .
24934342	0	AKT	44,47	phosphatidylinositol_3-kinase	14,43	AKT	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Targeting the phosphatidylinositol_3-kinase / AKT pathway for the treatment of multiple_myeloma .
25709476	0	AKT	90,93	phosphatidylinositol_3-kinase	60,89	AKT	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Andrographolide inhibits hypoxia-inducible_factor-1 through phosphatidylinositol_3-kinase / AKT pathway and suppresses breast_cancer growth .
25068972	0	AKT	138,141	phosphatidylinositol_3_kinase	108,137	AKT	phosphatidylinositol 3 kinase	207	5294	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Effect of 2-arachidonoylglycerol on myosin_light_chain phosphorylation and platelet activation : The role of phosphatidylinositol_3_kinase / AKT pathway .
25281324	0	AKT	140,143	phosphoinositide-3-kinase	114,139	AKT	phosphoinositide-3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Biphasic modulation of paracellular claudin-5 expression in mouse brain endothelial cells is mediated through the phosphoinositide-3-kinase / AKT pathway .
12242282	0	AKT	46,49	phosphoinositide_3-kinase	20,45	AKT	phosphoinositide 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	v-Crk activates the phosphoinositide_3-kinase / AKT pathway by utilizing focal_adhesion_kinase and H-Ras .
16935846	0	AKT	129,132	phosphoinositide_3-kinase	103,128	AKT	phosphoinositide 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Regulation of the RAP1/RAF -1 / extracellularly regulated kinase-1 / 2 cascade and prolactin release by the phosphoinositide_3-kinase / AKT pathway in pituitary cells .
17018259	0	AKT	56,59	phosphoinositide_3-kinase	30,55	AKT	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Emodin negatively affects the phosphoinositide_3-kinase / AKT signalling pathway : a study on its mechanism of action .
20501798	0	AKT	36,39	phosphoinositide_3-kinase	10,35	AKT	phosphoinositide 3-kinase	207	5293	Gene	Gene	signaling|compound|START_ENTITY confers|nsubj|signaling END_ENTITY|parataxis|confers	Activated phosphoinositide_3-kinase / AKT signaling confers resistance to trastuzumab but not lapatinib .
12458207	0	AKT	66,69	protein_kinase_B	49,65	AKT	protein kinase B	207	2185	Gene	Gene	leads|nsubj|START_ENTITY regulation|parataxis|leads regulation|nmod|END_ENTITY	Negative regulation of mixed_lineage_kinase_3 by protein_kinase_B / AKT leads to cell survival .
17534446	0	AKT	100,103	sp1	57,60	AKT	sp1	207	6667	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Membrane-type_1_matrix_metalloproteinase is regulated by sp1 through the differential activation of AKT , JNK , and ERK pathways in human prostate_tumor cells .
24482231	0	AKT	90,93	yes-associated_protein	141,163	AKT	yes-associated protein	207	10413	Gene	Gene	signaling|nsubj|START_ENTITY signaling|xcomp|exert exert|dobj|role role|nmod|END_ENTITY	Cluster of differentiation 166 -LRB- CD166 -RRB- regulated by phosphatidylinositide_3-Kinase -LRB- PI3K -RRB- / AKT signaling to exert its anti-apoptotic role via yes-associated_protein -LRB- YAP -RRB- in liver_cancer .
11997518	0	AKT-1	18,23	protein_kinase_B_alpha	24,46	AKT-1	protein kinase B alpha	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Essential role of AKT-1 / protein_kinase_B_alpha in PTEN-controlled tumorigenesis .
20132317	0	AKT1	20,24	AKTIP	33,38	AKT1	AKTIP	207	64400	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients .
23331977	0	AKT1	57,61	CBL10	27,32	AKT1	CBL10	817206(Tax:3702)	829437(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Calcineurin_B-like protein CBL10 directly interacts with AKT1 and modulates K + homeostasis in Arabidopsis .
26700476	0	AKT1	62,66	Caspase-9	29,38	AKT1	Caspase-9	207	842	Gene	Gene	Stimulation|nmod|START_ENTITY END_ENTITY|nmod|Stimulation	Cinnamomum cassia Suppresses Caspase-9 through Stimulation of AKT1 in MCF-7 Cells but Not in MDA-MB-231 Cells .
25065544	0	AKT1	18,22	Protein_kinase_B	0,16	AKT1	Protein kinase B	207	2185	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Protein_kinase_B -LRB- AKT1 -RRB- genotype mediates sensitivity to cannabis-induced impairments in psychomotor control .
25332163	0	AKT1	18,22	caspase	40,47	AKT1	caspase	41957(Tax:7227)	37729(Tax:7227)	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy .
22142798	0	AKT1	0,4	p27Kip1	60,67	AKT1	p27Kip1	207	1027	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cleavage cleavage|nmod|END_ENTITY	AKT1 induces caspase-mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD .
26450699	0	AKT1	147,151	protein_kinase_B	129,145	AKT1	protein kinase B	207	2185	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	MicroRNA-derived network analysis of differentially methylated genes in schizophrenia , implicating GABA_receptor_B1 -LSB- GABBR1 -RSB- and protein_kinase_B -LSB- AKT1 -RSB- .
26158514	0	AKT2	82,86	miR-612	0,7	AKT2	miR-612	208	693197	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-612 negatively regulates colorectal_cancer growth and metastasis by targeting AKT2 .
24463007	0	AKT3	0,4	ErbB2	15,20	AKT3	ErbB2	23797(Tax:10090)	13866(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	AKT3 regulates ErbB2 , ErbB3 and estrogen_receptor_a expression and contributes to endocrine therapy resistance of ErbB2 -LRB- + -RRB- breast_tumor cells from Balb-neuT mice .
21487925	0	AKT3	21,25	GNAQ	9,13	AKT3	GNAQ	10000	2776	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Uncommon GNAQ , MMP8 , AKT3 , EGFR , and PIK3R1 mutations in thyroid_cancers .
21487925	0	AKT3	21,25	MMP8	15,19	AKT3	MMP8	10000	4317	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Uncommon GNAQ , MMP8 , AKT3 , EGFR , and PIK3R1 mutations in thyroid_cancers .
24244539	0	AKT3	73,77	miR-122	0,7	AKT3	miR-122	23797(Tax:10090)	387231(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-122 regulates tumorigenesis in hepatocellular_carcinoma by targeting AKT3 .
20132317	0	AKTIP	33,38	AKT1	20,24	AKTIP	AKT1	64400	207	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients .
15192111	0	AKT_1	17,22	Protein_kinase_B	0,16	AKT 1	Protein kinase B	207	2185	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	Protein_kinase_B / AKT_1 plays a pivotal role in insulin-like_growth_factor-1_receptor signaling induced 3T3-L1 adipocyte differentiation .
20051463	0	AKT_and_14-3-3	53,67	EDC3	82,86	AKT and 14-3-3	EDC3	207;10971	80153	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Global phosphoproteomics identifies a major role for AKT_and_14-3-3 in regulating EDC3 .
21621563	0	AKT_and_14-3-3	31,45	FoxO3	22,27	AKT and 14-3-3	FoxO3	207;10971	2309	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bimodal regulation of FoxO3 by AKT_and_14-3-3 .
861203	0	AK_1	83,87	gamma-butyrobetaine_hydroxylase	31,62	AK 1	gamma-butyrobetaine hydroxylase	203	8424	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and properties of gamma-butyrobetaine_hydroxylase from Pseudomonas sp AK_1 .
21783619	0	ALAD	45,49	aminolevulinic_acid_dehydratase	12,43	ALAD	aminolevulinic acid dehydratase	210	210	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Reversal of aminolevulinic_acid_dehydratase -LRB- ALAD -RRB- inhibition and reduction of erythrocyte protoporphyrin levels by Vitamin_C in occupational lead exposure in Abeokuta , Nigeria .
8188255	0	ALAD	41,45	delta-aminolevulinate_dehydratase	6,39	ALAD	delta-aminolevulinate dehydratase	210	210	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human delta-aminolevulinate_dehydratase -LRB- ALAD -RRB- gene : structure and alternative splicing of the erythroid and housekeeping mRNAs .
15587989	0	ALAD	61,65	delta-aminolevulinic_acid_dehydratase	22,59	ALAD	delta-aminolevulinic acid dehydratase	100549846	100549846	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Molecular analysis of delta-aminolevulinic_acid_dehydratase -LRB- ALAD -RRB- gene polymorphism in a Turkish population .
17966070	0	ALAD	59,63	delta-aminolevulinic_acid_dehydratase	20,57	ALAD	delta-aminolevulinic acid dehydratase	210	210	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between delta-aminolevulinic_acid_dehydratase -LRB- ALAD -RRB- polymorphism and blood lead levels : a meta-regression analysis .
11857741	0	ALAP	84,88	adipocyte-derived_leucine_aminopeptidase	42,82	ALAP	adipocyte-derived leucine aminopeptidase	51752	51752	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of 33 polymorphisms in the adipocyte-derived_leucine_aminopeptidase -LRB- ALAP -RRB- gene and possible association with hypertension .
12121995	0	ALAS1	84,89	CXR	149,152	ALAS1	CXR	552895(Tax:9031)	395439(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Drugs mediate the transcriptional activation of the 5-aminolevulinic_acid synthase -LRB- ALAS1 -RRB- gene via the chicken xenobiotic-sensing nuclear receptor -LRB- CXR -RRB- .
19289130	0	ALAS1	92,97	Peroxisome_proliferator-activated_receptor_alpha	0,48	ALAS1	Peroxisome proliferator-activated receptor alpha	211	5465	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha controls hepatic heme biosynthesis through ALAS1 .
23926104	0	ALC1	184,188	Amplified_in_Liver_Cancer_1	155,182	ALC1	Amplified in Liver Cancer 1	9557	9557	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Tripartite_Motif-containing_33 -LRB- TRIM33 -RRB- protein functions in the poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- - dependent DNA damage response through interaction with Amplified_in_Liver_Cancer_1 -LRB- ALC1 -RRB- protein .
17964124	0	ALCAM	49,54	CD166	56,61	ALCAM	CD166	11658(Tax:10090)	11658(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Isolation of cardiac cells from E8 .5 yolk sac by ALCAM -LRB- CD166 -RRB- expression .
21560815	0	ALCAM	67,72	activated_leukocyte_adhesion_molecule	28,65	ALCAM	activated leukocyte adhesion molecule	397269(Tax:9823)	397269(Tax:9823)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Side-specific expression of activated_leukocyte_adhesion_molecule -LRB- ALCAM ; CD166 -RRB- in pathosusceptible regions of swine aortic valve endothelium .
24562769	0	ALCAM	24,29	miR126-5p	0,9	ALCAM	miR126-5p	214	100302116	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	miR126-5p repression of ALCAM and SetD5 in endothelial cells regulates leucocyte adhesion and transmigration .
8353517	0	ALDH	24,28	Aldehyde_dehydrogenase	0,22	ALDH	Aldehyde dehydrogenase	34256(Tax:7227)	34256(Tax:7227)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Aldehyde_dehydrogenase -LRB- ALDH -RRB- activity in Drosophila_melanogaster adults : evidence for cytosolic localization .
10780262	0	ALDH	35,39	aldehyde_dehydrogenase	11,33	ALDH	aldehyde dehydrogenase	11670(Tax:10090)	11670(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Eukaryotic aldehyde_dehydrogenase -LRB- ALDH -RRB- genes : human polymorphisms , and recommended nomenclature based on divergent evolution and chromosomal mapping .
2053494	0	ALDH	32,36	aldehyde_dehydrogenase	8,30	ALDH	aldehyde dehydrogenase	25375(Tax:10116)	25375(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of aldehyde_dehydrogenase -LRB- ALDH -RRB- in the detoxication of cyclophosphamide -LRB- CP -RRB- in rat embryos .
25843691	0	ALDH1	26,31	Aldehyde_dehydrogenase_1	0,24	ALDH1	Aldehyde dehydrogenase 1	216	216	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Aldehyde_dehydrogenase_1 -LRB- ALDH1 -RRB- expression is associated with a poor prognosis of bladder_cancer .
23803205	0	ALDH1	65,70	CD133	1,6	ALDH1	CD133	216	8842	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|END_ENTITY	-LSB- CD133 -LRB- + -RRB- Colo205 colorectal_cancer cells express high levels of ALDH1 in serum-free culture -RSB- .
25576341	0	ALDH1	48,53	CD133	54,59	ALDH1	CD133	216	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	microRNA-143 is associated with the survival of ALDH1 + CD133 + osteosarcoma cells and the chemoresistance of osteosarcoma .
26298632	0	ALDH1	74,79	CD133	67,72	ALDH1	CD133	216	8842	Gene	Gene	expressions|appos|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
26298632	0	ALDH1	74,79	CD24	55,59	ALDH1	CD24	216	100133941	Gene	Gene	expressions|appos|START_ENTITY expressions|compound|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
21062915	0	ALDH1	138,143	CD44	131,135	ALDH1	CD44	216	960	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Cucurbitacin_I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous_carcinoma -- derived CD44 -LRB- + -RRB- ALDH1 -LRB- + -RRB- cells .
24519209	0	ALDH1	0,5	CD44	91,95	ALDH1	CD44	216	960	Gene	Gene	indicator|nsubj|START_ENTITY indicator|advcl|phenotype phenotype|nsubj|+ +|compound|END_ENTITY	ALDH1 is a better clinical indicator for relapse of invasive_ductal_breast_cancer than the CD44 + / CD24 - phenotype .
24716927	0	ALDH1	0,5	CD44	26,30	ALDH1	CD44	216	960	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	ALDH1 in combination with CD44 as putative_cancer stem cell markers are correlated with poor prognosis in urothelial_carcinoma of the urinary_bladder .
26298632	0	ALDH1	74,79	CD44	61,65	ALDH1	CD44	216	960	Gene	Gene	expressions|appos|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
26399460	0	ALDH1	12,17	CD44	0,4	ALDH1	CD44	216	960	Gene	Gene	characteristics|nummod|START_ENTITY END_ENTITY|dep|characteristics	CD44 -LRB- high -RRB- / ALDH1 -LRB- high -RRB- head_and_neck_squamous_cell_carcinoma cells exhibit mesenchymal characteristics and GSK3b-dependent cancer stem cell properties .
25451256	0	ALDH1	31,36	Fibulin-3	0,9	ALDH1	Fibulin-3	216	2202	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases y-radiation-induced sensitivity in some pancreatic_cancer cell lines .
24402192	0	ALDH1	111,116	TWIST1	0,6	ALDH1	TWIST1	216	7291	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	TWIST1 and SNAI1 as markers of poor prognosis in human colorectal_cancer are associated with the expression of ALDH1 and TGF-b1 .
3189338	0	ALDH1	161,166	aldehyde_dehydrogenase	132,154	ALDH1	aldehyde dehydrogenase	216	217	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver_diseases : a strong association of the usual Caucasian-type aldehyde_dehydrogenase gene -LRB- ALDH1 -LRB- 2 -RRB- -RRB- with the disease .
21231983	0	ALDH1	40,45	aldehyde_dehydrogenase_1	14,38	ALDH1	aldehyde dehydrogenase 1	216	216	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of aldehyde_dehydrogenase_1 -LRB- ALDH1 -RRB- in endometrioid_adenocarcinoma and its clinical implications .
21176222	0	ALDH1	55,60	aldehyde_dehydrogenase_1a1	27,53	ALDH1	aldehyde dehydrogenase 1a1	216	216	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of aldehyde_dehydrogenase_1a1 -LRB- ALDH1 -RRB- in normal ovary_and_serous_ovarian_tumors .
22144423	0	ALDH1A1	0,7	EZH2	19,23	ALDH1A1	EZH2	216	2146	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	ALDH1A1 is a novel EZH2 target gene in epithelial_ovarian_cancer identified by genome-wide approaches .
26705040	0	ALDH1A1	34,41	aldehyde_dehydrogenase_1A1	6,32	ALDH1A1	aldehyde dehydrogenase 1A1	216	216	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- High aldehyde_dehydrogenase_1A1 -LRB- ALDH1A1 -RRB- expression correlated with risk of lymph_node_metastasis in papillary_thyroid_carcinoma -RSB- .
25969992	0	ALDH1A3	44,51	MiR-187	0,7	ALDH1A3	MiR-187	220	406963	Gene	Gene	Targets|dobj|START_ENTITY Targets|nsubj|END_ENTITY	MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate_Cancer .
17526768	0	ALDH1A3	51,58	aldehyde_dehydrogenase_1A3	23,49	ALDH1A3	aldehyde dehydrogenase 1A3	220	220	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Androgen regulation of aldehyde_dehydrogenase_1A3 -LRB- ALDH1A3 -RRB- in the androgen-responsive human prostate_cancer cell line LNCaP .
20729910	0	ALDH1L1	0,7	PP1	67,70	ALDH1L1	PP1	10840	5464	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A .
15639999	0	ALDH2	25,30	Aldehyde_dehydrogenase	1,23	ALDH2	Aldehyde dehydrogenase	217	217	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Aldehyde_dehydrogenase -LRB- ALDH2 -RRB- polymorphism and drinking behavior -RSB- .
26379870	0	ALDH2	26,31	Aldehyde_dehydrogenase_2	0,24	ALDH2	Aldehyde dehydrogenase 2	217	217	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- Glu504Lys polymorphism is associated with hypertension risk in Asians : a meta-analysis .
20598484	0	ALDH2	23,28	CYP2E1	30,36	ALDH2	CYP2E1	217	1571	Gene	Gene	Distribution|nmod|START_ENTITY END_ENTITY|nsubj|Distribution	Distribution of ADH1B , ALDH2 , CYP2E1 * 6 , and CYP2E1 * 7B genotypes in Turkish population .
25244799	0	ALDH2	26,31	JNK	64,67	ALDH2	JNK	24188(Tax:10116)	116554(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of activation of ALDH2 by ethanol on the expression of JNK in kidney of diabetic rats -RSB- .
8516360	0	ALDH2	38,43	Mitochondrial_aldehyde_dehydrogenase	0,36	ALDH2	Mitochondrial aldehyde dehydrogenase	29539(Tax:10116)	29539(Tax:10116)	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Mitochondrial_aldehyde_dehydrogenase -LRB- ALDH2 -RRB- polymorphism in AA and ANA rats : lack of genotype and phenotype line differences .
10627091	0	ALDH2	84,89	aldehyde_dehydrogenase	60,82	ALDH2	aldehyde dehydrogenase	217	217	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hangover_symptoms in Asian Americans with variations in the aldehyde_dehydrogenase -LRB- ALDH2 -RRB- gene .
15329927	0	ALDH2	70,75	aldehyde_dehydrogenase_2	44,68	ALDH2	aldehyde dehydrogenase 2	217	217	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphism detection in aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- gene using bacterial magnetic particles based on dissociation curve analysis .
18776700	0	ALDH2	54,59	aldehyde_dehydrogenase_2	28,52	ALDH2	aldehyde dehydrogenase 2	217	217	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Genetic association between aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- variation and high-density lipoprotein cholesterol -LRB- HDL-C -RRB- among non-drinkers in two large population samples in Japan .
1916152	0	ALDH2	44,49	aldehyde_dehydrogenase_2	18,42	ALDH2	aldehyde dehydrogenase 2	217	217	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotyping of the aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- gene using the polymerase chain reaction : evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency .
19914339	0	ALDH2	52,57	aldehyde_dehydrogenase_2	26,50	ALDH2	aldehyde dehydrogenase 2	217	217	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Absence of association on aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- polymorphism with Mongolian Alzheimer patients .
22870576	0	ALDH2	44,49	aldehyde_dehydrogenase_2	18,42	ALDH2	aldehyde dehydrogenase 2	217	217	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of an aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- gene polymorphism with hyper-low-density_lipoprotein_cholesterolemia in a Japanese population .
18772068	0	ALDH2	147,152	calcitonin_gene-related_peptide	28,59	ALDH2	calcitonin gene-related peptide	217	796	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Evidence for involvement of calcitonin_gene-related_peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 -LRB- ALDH2 -RRB- Glu504Lys polymorphism .
26254233	0	ALDH2	52,57	mitochondrial_aldehyde_dehydrogenase	14,50	ALDH2	mitochondrial aldehyde dehydrogenase	29539(Tax:10116)	29539(Tax:10116)	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	The impact of mitochondrial_aldehyde_dehydrogenase -LRB- ALDH2 -RRB- activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression .
7779080	0	ALDH5	39,44	aldehyde_dehydrogenase	10,32	ALDH5	aldehyde dehydrogenase	219	217	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The novel aldehyde_dehydrogenase gene , ALDH5 , encodes an active aldehyde_dehydrogenase enzyme .
8244338	0	ALDH5	89,94	aldehyde_dehydrogenase-5	63,87	ALDH5	aldehyde dehydrogenase-5	219	219	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Diverse polymorphism within a short coding region of the human aldehyde_dehydrogenase-5 -LRB- ALDH5 -RRB- gene .
14635103	0	ALDH5A1	65,72	succinate_semialdehyde_dehydrogenase	27,63	ALDH5A1	succinate semialdehyde dehydrogenase	7915	7915	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational spectrum of the succinate_semialdehyde_dehydrogenase -LRB- ALDH5A1 -RRB- gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH_deficiency .
1842923	0	ALDH_3	85,91	BCP_54	78,84	ALDH 3	BCP 54	281617(Tax:9913)	281617(Tax:9913)	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Degenerate oligonucleotide sequence-directed cross-species PCR cloning of the BCP_54 / ALDH_3 cDNA : priming from inverted repeats and formation of tandem primer arrays .
12065405	0	ALDP	94,98	COMATOSE	49,57	ALDP	COMATOSE	215	830144(Tax:3702)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Control of germination and lipid mobilization by COMATOSE , the Arabidopsis homologue of human ALDP .
11342107	0	ALDR	34,38	adrenoleukodystrophy-related	4,32	ALDR	adrenoleukodystrophy-related	84356(Tax:10116)	84356(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rat adrenoleukodystrophy-related -LRB- ALDR -RRB- gene : full-length cDNA sequence and new insight in expression .
10329405	0	ALDR	113,117	adrenoleukodystrophy_related	83,111	ALDR	adrenoleukodystrophy related	225	225	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Full length cDNA cloning , promoter sequence , and genomic organization of the human adrenoleukodystrophy_related -LRB- ALDR -RRB- gene functionally redundant to the gene responsible for X-linked_adrenoleukodystrophy .
9345306	0	ALDRP	84,89	ABC_transporter	106,121	ALDRP	ABC transporter	225	9429	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	cDNA cloning and mRNA expression of the human adrenoleukodystrophy_related protein -LRB- ALDRP -RRB- , a peroxisomal ABC_transporter .
18940611	0	ALG-2	50,55	Alix	56,60	ALG-2	Alix	85365	10015	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Structural basis for Ca2 + - dependent formation of ALG-2 / Alix peptide complex : Ca2 + / EF3-driven arginine switch mechanism .
16698022	0	ALG-2	53,58	POSH	0,4	ALG-2	POSH	3355106(Tax:7227)	36990(Tax:7227)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	POSH , a scaffold protein for JNK signaling , binds to ALG-2 and ALIX in Drosophila .
16957052	0	ALG-2	25,30	Sec31A	83,89	ALG-2	Sec31A	85365	22872	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	The Ca2 + - binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A .
17196169	0	ALG-2	0,5	Sec31A	21,27	ALG-2	Sec31A	85365	22872	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2 + - dependent manner .
16004603	0	ALG-2	26,31	TSG101	78,84	ALG-2	TSG101	85365	7251	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101 , and Ca2 + - dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B .
22162750	0	ALIX	73,77	Bro1	78,82	ALIX	Bro1	10015	856021(Tax:4932)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding .
10702393	0	ALK	26,29	ATIC-ALK	0,8	ALK	ATIC-ALK	238	471;238	Gene	Gene	fusion|compound|START_ENTITY END_ENTITY|dep|fusion	ATIC-ALK : A novel variant ALK gene fusion in anaplastic_large_cell_lymphoma resulting from the recurrent cryptic chromosomal inversion , inv -LRB- 2 -RRB- -LRB- p23q35 -RRB- .
11684952	0	ALK	28,31	Anaplastic_lymphoma_kinase	0,26	ALK	Anaplastic lymphoma kinase	238	238	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- expression in the inflammatory_myofibroblastic_tumor : a comparative immunohistochemical study .
26179668	0	ALK	28,31	Anaplastic_lymphoma_kinase	0,26	ALK	Anaplastic lymphoma kinase	238	238	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- translocation in paediatric_malignant_peritoneal_mesothelioma : a case report of novel ALK-related tumour spectrum .
26373952	0	ALK	47,50	BRAF	41,45	ALK	BRAF	238	673	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
16796648	0	ALK	94,97	CD30	59,63	ALK	CD30	238	943	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Cutaneous presentation on the eyelid of primary , systemic , CD30 + , anaplastic_lymphoma kinase -LRB- ALK -RRB- - negative , anaplastic_large-cell_lymphoma -LRB- ALCL -RRB- .
22787409	0	ALK	58,61	EGFR	52,56	ALK	EGFR	238	1956	Gene	Gene	MET|appos|START_ENTITY MET|compound|END_ENTITY	Biomarkers that currently affect clinical practice : EGFR , ALK , MET , KRAS .
26373952	0	ALK	47,50	EGFR	29,33	ALK	EGFR	238	1956	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|compound|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
25351247	0	ALK	11,14	ERK5	37,41	ALK	ERK5	238	5598	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma .
16939498	0	ALK	168,171	Janus_kinase-3	34,48	ALK	Janus kinase-3	238	3718	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	JSI-124 -LRB- cucurbitacin_I -RRB- inhibits Janus_kinase-3 / signal_transducer_and_activator_of_transcription-3 signalling , downregulates nucleophosmin-anaplastic_lymphoma kinase -LRB- ALK -RRB- , and induces apoptosis in ALK-positive_anaplastic_large_cell_lymphoma cells .
22787409	0	ALK	58,61	KRAS	68,72	ALK	KRAS	238	3845	Gene	Gene	MET|appos|START_ENTITY MET|dep|END_ENTITY	Biomarkers that currently affect clinical practice : EGFR , ALK , MET , KRAS .
26373952	0	ALK	47,50	KRAS	35,39	ALK	KRAS	238	3845	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
22439933	0	ALK	10,13	MYCN	32,36	ALK	MYCN	564470(Tax:7955)	252851(Tax:7955)	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	Activated ALK collaborates with MYCN in neuroblastoma pathogenesis .
24356251	0	ALK	0,3	MYCN	9,13	ALK	MYCN	11682(Tax:10090)	18109(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma .
9028963	0	ALK	41,44	NPM	83,86	ALK	NPM	238	4869	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Detection of anaplastic_lymphoma kinase -LRB- ALK -RRB- and nucleolar protein nucleophosmin -LRB- NPM -RRB- - ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1 .
26373952	0	ALK	47,50	PIK3CA	52,58	ALK	PIK3CA	238	5290	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
14506160	0	ALK	86,89	STAT3	77,82	ALK	STAT3	238	6774	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK + and ALK - anaplastic_large_cell_lymphoma .
11850821	0	ALK	28,31	Stat3	43,48	ALK	Stat3	238	6774	Gene	Gene	Anaplastic_lymphoma_kinase|appos|START_ENTITY activates|nsubj|Anaplastic_lymphoma_kinase activates|dobj|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- activates Stat3 and protects hematopoietic cells from cell death .
16604305	0	ALK	92,95	anaplastic_lymphoma_kinase	64,90	ALK	anaplastic lymphoma kinase	238	238	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Possible association between nonsynonymous polymorphisms of the anaplastic_lymphoma_kinase -LRB- ALK -RRB- gene and schizophrenia in a Japanese population .
20632993	0	ALK	25,28	anaplastic_lymphoma_kinase	30,56	ALK	anaplastic lymphoma kinase	238	238	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Crystal structure of the ALK -LRB- anaplastic_lymphoma_kinase -RRB- catalytic domain .
22280150	0	ALK	88,91	anaplastic_lymphoma_kinase	60,86	ALK	anaplastic lymphoma kinase	238	238	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inflammatory_myofibroblastic_tumor of the lung in children : anaplastic_lymphoma_kinase -LRB- ALK -RRB- expression and clinico-pathological correlation .
22705117	0	ALK	143,146	anaplastic_lymphoma_kinase	115,141	ALK	anaplastic lymphoma kinase	238	238	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Multiparametric molecular characterization of pulmonary_sarcomatoid_carcinoma reveals a nonrandom amplification of anaplastic_lymphoma_kinase -LRB- ALK -RRB- gene .
23050789	0	ALK	39,42	anaplastic_lymphoma_kinase	11,37	ALK	anaplastic lymphoma kinase	238	238	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rearranged anaplastic_lymphoma_kinase -LRB- ALK -RRB- gene in adult-onset papillary_thyroid_cancer amongst atomic bomb survivors .
23880539	0	ALK	59,62	anaplastic_lymphoma_kinase	31,57	ALK	anaplastic lymphoma kinase	238	238	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of 7-azaindole based anaplastic_lymphoma_kinase -LRB- ALK -RRB- inhibitors : wild type and mutant -LRB- L1196M -RRB- active compounds with unique binding mode .
25200979	0	ALK	133,136	anaplastic_lymphoma_kinase	105,131	ALK	anaplastic lymphoma kinase	238	238	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis and pharmacological evaluation of 2 - -LRB- thiazol-2-amino -RRB- -4 - arylaminopyrimidines as potent anaplastic_lymphoma_kinase -LRB- ALK -RRB- inhibitors .
26130408	0	ALK	123,126	anaplastic_lymphoma_kinase	95,121	ALK	anaplastic lymphoma kinase	266802(Tax:10116)	266802(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of 2-arylamino-4 - -LRB- 1-methyl-3-isopropylsulfonyl-4-pyrazol-amino -RRB- pyrimidines as potent anaplastic_lymphoma_kinase -LRB- ALK -RRB- inhibitors .
16084951	0	ALK	40,43	cyclin_D3	27,36	ALK	cyclin D3	238	896	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential expression of cyclin_D3 in ALK + and ALK - anaplastic_large_cell_lymphoma .
25997961	0	ALK	63,66	miR-1271	0,8	ALK	miR-1271	238	100302203	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-1271 inhibits OSCC cell growth and metastasis by targeting ALK .
12393874	0	ALK-1	14,19	LXRbeta	54,61	ALK-1	LXRbeta	94	7376	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of ALK-1 signaling by the nuclear receptor LXRbeta .
23707512	0	ALK-1	4,9	Smad1	10,15	ALK-1	Smad1	94	4086	Gene	Gene	START_ENTITY|parataxis|pathway pathway|nsubj|END_ENTITY	The ALK-1 / Smad1 pathway in cardiovascular physiopathology .
17219009	0	ALK-1	61,66	activin_receptor-like_kinase_1	29,59	ALK-1	activin receptor-like kinase 1	94	94	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Three novel mutations in the activin_receptor-like_kinase_1 -LRB- ALK-1 -RRB- gene in hereditary_hemorrhagic_telangiectasia_type_2 in Brazilian patients .
10664470	0	ALK-5	63,68	TGF-beta_type_I_receptor	32,56	ALK-5	TGF-beta type I receptor	29591(Tax:10116)	29591(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternative splicing within the TGF-beta_type_I_receptor gene -LRB- ALK-5 -RRB- generates two major functional isoforms in vascular smooth muscle cells .
17197570	0	ALK-5	0,5	connective_tissue_growth_factor	62,93	ALK-5	connective tissue growth factor	21812(Tax:10090)	14219(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	ALK-5 mediates endogenous and TGF-beta1-induced expression of connective_tissue_growth_factor in embryonic lung .
20056902	0	ALK1	85,89	ACVRL1	77,83	ALK1	ACVRL1	94	94	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Clinical outcomes of pulmonary_arterial_hypertension in patients carrying an ACVRL1 -LRB- ALK1 -RRB- mutation .
17911384	0	ALK1	37,41	ALK5	0,4	ALK1	ALK5	11482(Tax:10090)	21812(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|amod|END_ENTITY	ALK5 - and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary_hemorrhagic_telangiectasia_type_2 .
17311849	0	ALK1	18,22	BMP-9	0,5	ALK1	BMP-9	94	2658	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis .
25297851	0	ALK1	110,114	BMP-9	0,5	ALK1	BMP-9	6590	2658	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway .
18065769	0	ALK1	93,97	Caveolin-1	0,10	ALK1	Caveolin-1	94	857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae .
16705692	0	ALK1	32,36	ENG	16,19	ALK1	ENG	94	2022	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of ENG and ACVRL1 -LRB- ALK1 -RRB- mutations in French HHT patients .
15059530	0	ALK1	48,52	activin_receptor-like_kinase_1	17,47	ALK1	activin receptor-like kinase 1	94	94	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Mutation of the activin_receptor-like_kinase_1 -LRB- ALK1 -RRB- gene and the expression of plasma thrombomodulin in type-2 hereditary_hemorrhagic_telangiectasia : a study of a Chinese family -RSB- .
18159113	0	ALK1	66,70	activin_receptor-like_kinase_1	29,59	ALK1	activin receptor-like kinase 1	94	94	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Implications of mutations of activin_receptor-like_kinase_1 gene -LRB- ALK1 -RRB- in addition to bone morphogenetic protein receptor II gene -LRB- BMPR2 -RRB- in children with pulmonary_arterial_hypertension .
9748228	0	ALK2	77,81	BMP7	55,59	ALK2	BMP7	11477(Tax:10090)	12162(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Specific activation of Smad1 signaling pathways by the BMP7 type I receptor , ALK2 .
19736306	0	ALK2	28,32	Endoglin	0,8	ALK2	Endoglin	90	2022	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Endoglin phosphorylation by ALK2 contributes to the regulation of prostate_cancer cell migration .
18684712	0	ALK2	25,29	bone_morphogenetic_protein	73,99	ALK2	bone morphogenetic protein	90	649	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone_morphogenetic_protein signaling in fibrodysplasia ossificans progressiva .
10633078	0	ALK3	6,10	BMP-2	0,5	ALK3	BMP-2	12166(Tax:10090)	12156(Tax:10090)	Gene	Gene	signal|nsubj|START_ENTITY END_ENTITY|appos|signal	BMP-2 / ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis .
24904118	0	ALK3	43,47	HFE	0,3	ALK3	HFE	657	3077	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression .
12065756	0	ALK4	144,148	ALK5	150,154	ALK4	ALK5	91	7046	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase -LRB- ALK -RRB- receptors ALK4 , ALK5 , and ALK7 .
12665502	0	ALK4	79,83	activin	48,55	ALK4	activin	91	83729	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|site site|nmod|END_ENTITY	Identification of a functional binding site for activin on the type I receptor ALK4 .
17911384	0	ALK5	0,4	ALK1	37,41	ALK5	ALK1	21812(Tax:10090)	11482(Tax:10090)	Gene	Gene	role|amod|START_ENTITY role|nmod|END_ENTITY	ALK5 - and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary_hemorrhagic_telangiectasia_type_2 .
12065756	0	ALK5	150,154	ALK4	144,148	ALK5	ALK4	7046	91	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase -LRB- ALK -RRB- receptors ALK4 , ALK5 , and ALK7 .
16845371	0	ALK5	94,98	Growth_differentiation_factor_11	0,32	ALK5	Growth differentiation factor 11	21812(Tax:10090)	14561(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Growth_differentiation_factor_11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis .
18421620	0	ALK5	127,131	activin_receptor-like_kinase-5	95,125	ALK5	activin receptor-like kinase-5	7046	7046	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Identification of human cytochrome_P450 enzymes involved in the metabolism of IN-1130 , a novel activin_receptor-like_kinase-5 -LRB- ALK5 -RRB- inhibitor .
25234355	0	ALK5	155,159	transforming_growth_factor-b	102,130	ALK5	transforming growth factor-b	7046	7040	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Design , synthesis and evaluation of small molecule imidazo -LSB- 2,1-b -RSB- -LSB- 1,3,4 -RSB- thiadiazoles as inhibitors of transforming_growth_factor-b type-I receptor kinase -LRB- ALK5 -RRB- .
15993878	0	ALK5	103,107	transforming_growth_factor_beta	57,88	ALK5	transforming growth factor beta	7046	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Altered primordial germ cell migration in the absence of transforming_growth_factor_beta signaling via ALK5 .
11855979	0	ALK5	104,108	transforming_growth_factor_beta1	42,74	ALK5	transforming growth factor beta1	7046	7040	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Identification of novel inhibitors of the transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- type 1 receptor -LRB- ALK5 -RRB- .
22374147	0	ALK6	34,38	BMPR1B	26,32	ALK6	BMPR1B	658	658	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Missense mutations of the BMPR1B -LRB- ALK6 -RRB- gene in childhood idiopathic_pulmonary_arterial_hypertension .
26406402	0	ALK7	34,38	B2M	18,21	ALK7	B2M	130399	567	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Overexpression of B2M and loss of ALK7 expression are associated with invasion , metastasis , and poor-prognosis of the pancreatic_ductal_adenocarcinoma .
23577621	0	ALKBH1	91,97	AP_lyase	64,72	ALKBH1	AP lyase	8846	328	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	A covalent protein-DNA 5 ' - product adduct is generated following AP_lyase activity of human ALKBH1 -LRB- AlkB_homologue_1 -RRB- .
21285982	0	ALKBH3	0,6	AlkB	16,20	ALKBH3	AlkB	221120	8846	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	ALKBH3 , a human AlkB homologue , contributes to cell survival in human non-small-cell lung_cancer .
22826605	0	ALKBH3	6,12	PCA-1	0,5	ALKBH3	PCA-1	221120	221120	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|appos|contributes	PCA-1 / ALKBH3 contributes to pancreatic_cancer by supporting apoptotic resistance and angiogenesis .
25303482	0	ALKBH5	124,130	FTO	97,100	ALKBH5	FTO	54890	79068	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Decreased_N -LRB- 6 -RRB- - methyladenosine in peripheral blood RNA from Diabetic Patients Is Associated with FTO Expression Rather than ALKBH5 .
25452335	0	ALKBH5	69,75	FTO	39,42	ALKBH5	FTO	54890	79068	Gene	Gene	m6A|nmod|START_ENTITY demethylation|nmod|m6A demethylation|compound|END_ENTITY	Meclofenamic_acid selectively inhibits FTO demethylation of m6A over ALKBH5 .
8703835	0	ALL-1	35,40	MLL	42,45	ALL-1	MLL	100310785	4297	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Exon/intron structure of the human ALL-1 -LRB- MLL -RRB- gene involved in translocations to chromosomal region 11q23 and acute_leukaemias .
8934551	0	ALL-1	0,5	unr	21,24	ALL-1	unr	100310785	7812	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ALL-1 interacts with unr , a protein containing multiple cold shock domains .
11196198	0	ALL1	46,50	MLL	41,44	ALL1	MLL	100310785	4297	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The partial nontandem duplication of the MLL -LRB- ALL1 -RRB- gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell_acute_lymphoblastic_leukemia .
26341630	0	ALL1-fused_from_chromosome_1q	63,92	RE1_silencing_transcription_factor	0,34	ALL1-fused from chromosome 1q	RE1 silencing transcription factor	10962	5978	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	RE1_silencing_transcription_factor -LRB- REST -RRB- negatively regulates ALL1-fused_from_chromosome_1q -LRB- AF1q -RRB- gene transcription .
20011686	0	ALOX5	48,53	5-lipoxygenase	27,41	ALOX5	5-lipoxygenase	25290(Tax:10116)	25290(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cardioprotective effect of 5-lipoxygenase gene -LRB- ALOX5 -RRB- silencing in ischemia-reperfusion .
26944113	0	ALOX5	29,34	Arachidonate_5-lipoxygenase	0,27	ALOX5	Arachidonate 5-lipoxygenase	240	240	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Arachidonate_5-lipoxygenase -LRB- ALOX5 -RRB- gene polymorphism is associated with Alzheimer 's _ disease and body mass index .
26632627	0	ALOX5	117,122	arachidonate_5-lipoxygenase	88,115	ALOX5	arachidonate 5-lipoxygenase	240	240	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate_5-lipoxygenase -LRB- ALOX5 -RRB- promoter genotype : a multicentre , randomised , placebo-controlled trial BACKGROUND : The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear .
12911785	0	ALOX5AP	91,98	5-lipoxygenase	29,43	ALOX5AP	5-lipoxygenase	241	240	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Promoter polymorphism in the 5-lipoxygenase -LRB- ALOX5 -RRB- and 5-lipoxygenase-activating protein -LRB- ALOX5AP -RRB- genes and asthma susceptibility in a Caucasian population .
18775537	0	ALOX5AP	48,55	Arachidonate_5-lipoxygenase-activating_protein	0,46	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	241	241	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and coronary_heart_disease risk in familial_hypercholesterolemia .
24635928	0	ALOX5AP	48,55	Arachidonate_5-lipoxygenase-activating_protein	0,46	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	241	241	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene rs4073259 polymorphism not associated with ischemic_stroke in the northeastern Chinese Han population .
16278051	0	ALOX5AP	33,40	FLAP	27,31	ALOX5AP	FLAP	11690(Tax:10090)	11690(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	5-Lipoxygenase -LRB- ALOX5 -RRB- and FLAP -LRB- ALOX5AP -RRB- gene polymorphisms as factors in vascular pathology and Alzheimer 's _ disease .
19126581	0	ALOX5AP	64,71	arachidonate_5-lipoxygenase-activating_protein	16,62	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	241	241	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of the arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and risk of stroke : a HuGE gene-disease association review and meta-analysis .
21199733	0	ALOX5AP	60,67	arachidonate_5-lipoxygenase-activating_protein	12,58	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	241	241	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and risk of coronary_heart_disease : A meta-analysis .
23554707	0	ALOX5AP	64,71	arachidonate_5-lipoxygenase-activating_protein	16,62	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	241	241	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of the arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and risk of ischemic_stroke in Han Chinese of eastern China .
16728240	0	ALP	14,17	TNF-alpha	30,39	ALP	TNF-alpha	250	7124	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of ALP activity by TNF-alpha on human_dental_pulp .
10063829	0	ALP	61,64	actinin-associated_LIM_protein	29,59	ALP	actinin-associated LIM protein	27295	27295	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exclusion of muscle specific actinin-associated_LIM_protein -LRB- ALP -RRB- gene from 4q35 facioscapulohumeral muscular_dystrophy -LRB- FSHD -RRB- candidate genes .
16567122	0	ALP	44,47	alkaline_phosphatase	22,42	ALP	alkaline phosphatase	250	250	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression of alkaline_phosphatase -LRB- ALP -RRB- in the liver of primary_biliary_cirrhosis -LRB- PBC -RRB- patients .
20382118	0	ALR	63,66	Foxa2	0,5	ALR	Foxa2	2671	3170	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Foxa2 -LRB- HNF-3beta -RRB- regulates expression of hepatotrophic factor ALR in liver cells .
12837691	0	ALS2	0,4	Rab5	70,74	ALS2	Rab5	57679	5868	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	ALS2 , a novel guanine_nucleotide exchange factor for the small GTPase Rab5 , is implicated in endosomal dynamics .
15388334	0	ALS2CL	0,6	Rab5	91,95	ALS2CL	Rab5	259173	5868	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	ALS2CL , the novel protein highly homologous to the carboxy-terminal half of ALS2 , binds to Rab5 and modulates endosome dynamics .
16880512	0	ALX	118,121	interleukin-2	23,36	ALX	interleukin-2	14294(Tax:10090)	16183(Tax:10090)	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX .
23288509	0	ALX1	0,4	snail	13,18	ALX1	snail	8092	6615	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian_cancer cells .
26722397	0	ALX1	0,4	snail	77,82	ALX1	snail	8092	6615	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	ALX1 promotes migration and invasion of lung_cancer cells through increasing snail expression .
17920884	0	ALXR	60,64	hFPRL1	49,55	ALXR	hFPRL1	2358	2358	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	New ` chemical probes ' to examine the role of the hFPRL1 -LRB- or ALXR -RRB- receptor in inflammation .
9119228	0	ALY	0,3	TCRalpha	73,81	ALY	TCRalpha	10189	28755	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|compound|END_ENTITY	ALY , a context-dependent coactivator of LEF-1 and AML-1 , is required for TCRalpha enhancer function .
16781706	0	AM1241	0,6	CB2	22,25	AM1241	CB2	3171117(Tax:234826)	12802(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	AM1241 , a cannabinoid CB2 receptor selective compound , delays disease progression in a mouse model of amyotrophic_lateral_sclerosis .
20519143	0	AM803	16,21	five-lipoxygenase-activating_protein	41,77	AM803	five-lipoxygenase-activating protein	3171503(Tax:234826)	29624(Tax:10116)	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Pharmacology of AM803 , a novel selective five-lipoxygenase-activating_protein -LRB- FLAP -RRB- inhibitor in rodent models of acute inflammation .
18434322	0	AMACO	116,121	VWA2	123,127	AMACO	VWA2	340706	340706	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO -LRB- VWA2 protein -RRB- .
19861176	0	AMACO	18,23	VWA2	25,29	AMACO	VWA2	567428(Tax:7955)	567428(Tax:7955)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Expression of the AMACO -LRB- VWA2 protein -RRB- ortholog in zebrafish .
15602744	0	AMACR	31,36	Alpha-methylacyl-CoA_racemase	0,29	AMACR	Alpha-methylacyl-CoA racemase	23600	23600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Alpha-methylacyl-CoA_racemase -LRB- AMACR -RRB- expression in normal prostatic glands and high-grade prostatic_intraepithelial_neoplasia -LRB- HGPIN -RRB- : association with diagnosis of prostate_cancer .
26888362	0	AMACR	27,32	a-methylacyl-CoA_racemase	0,25	AMACR	a-methylacyl-CoA racemase	23600	23600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	a-methylacyl-CoA_racemase -LRB- AMACR -RRB- expression in chordomas differentiates them from chondrosarcomas .
16224209	0	AMACR	53,58	alpha-methyl_CoA_racemase	26,51	AMACR	alpha-methyl CoA racemase	23600	23600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Age-associated changes in alpha-methyl_CoA_racemase -LRB- AMACR -RRB- expression in nonneoplastic prostatic tissues .
22009118	0	AMACR	47,52	alpha-methyl_CoA_racemase	20,45	AMACR	alpha-methyl CoA racemase	23600	23600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic value of alpha-methyl_CoA_racemase -LRB- AMACR -RRB- expression in renal_cell_carcinoma .
9126491	0	AMBN	19,23	Ameloblastin	0,12	AMBN	Ameloblastin	258	258	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Ameloblastin gene -LRB- AMBN -RRB- maps within the critical region for autosomal_dominant_amelogenesis_imperfecta at chromosome 4q21 .
20602574	0	AMBP	48,52	Bikunin	0,7	AMBP	Bikunin	259	259	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Bikunin and a1-microglobulin/bikunin _ precursor -LRB- AMBP -RRB- gene mutational screening in patients with kidney_stones : a case-control study .
23524951	0	AMBRA1	98,104	mTOR	0,4	AMBRA1	mTOR	55626	21977(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	mTOR inhibits autophagy by controlling ULK1 ubiquitylation , self-association and function through AMBRA1 and TRAF6 .
7789170	0	AMD1	136,140	AMD2	162,166	AMD1	AMD2	262	263	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The human S-adenosylmethionine_decarboxylase gene : nucleotide sequence of a pseudogene and chromosomal localization of the active gene -LRB- AMD1 -RRB- and the pseudogene -LRB- AMD2 -RRB- .
7789170	0	AMD2	162,166	AMD1	136,140	AMD2	AMD1	263	262	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The human S-adenosylmethionine_decarboxylase gene : nucleotide sequence of a pseudogene and chromosomal localization of the active gene -LRB- AMD1 -RRB- and the pseudogene -LRB- AMD2 -RRB- .
23426651	0	AMELY	31,36	amelogenin_Y-linked	10,29	AMELY	amelogenin Y-linked	266	266	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Activated amelogenin_Y-linked -LRB- AMELY -RRB- regulation and angiogenesis in human hepatocellular_carcinoma by biocomputation .
11755821	0	AMF	81,84	autocrine_motility_factor	54,79	AMF	autocrine motility factor	2821	2821	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Regulation of cell motility via high and low affinity autocrine_motility_factor -LRB- AMF -RRB- receptor in human oral squamous_carcinoma cells .
12374700	0	AMF	100,103	autocrine_motility_factor	73,98	AMF	autocrine motility factor	2821	2821	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Antihuman epidermal_growth_factor_receptor_2 antibody herceptin inhibits autocrine_motility_factor -LRB- AMF -RRB- expression and potentiates antitumor effects of AMF inhibitors .
25932104	0	AMH	18,21	AMH	29,32	AMH	AMH	268	268	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of serum AMH and FF AMH in predicting pregnancy outcome in the fresh cycle of IVF/ICSI : a meta-analysis .
25932104	0	AMH	29,32	AMH	18,21	AMH	AMH	268	268	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of serum AMH and FF AMH in predicting pregnancy outcome in the fresh cycle of IVF/ICSI : a meta-analysis .
26834019	0	AMH	51,54	AMH	96,99	AMH	AMH	102180665	102180665	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of the Anti-M llerian Hormone -LRB- AMH -RRB- in Caprine Follicles and the Effects of AMH on In Vitro Culture of Caprine Pre-antral Follicles Enclosed in Ovarian Tissue .
26834019	0	AMH	96,99	AMH	51,54	AMH	AMH	102180665	102180665	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of the Anti-M llerian Hormone -LRB- AMH -RRB- in Caprine Follicles and the Effects of AMH on In Vitro Culture of Caprine Pre-antral Follicles Enclosed in Ovarian Tissue .
11602354	0	AMH	104,107	SAP62	73,78	AMH	SAP62	268	8175	Gene	Gene	SF3A2|nmod|START_ENTITY SF3A2|appos|END_ENTITY	An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 -LRB- SAP62 -RRB- immediately upstream of AMH .
8541848	0	AMH	77,80	SAP62	37,42	AMH	SAP62	268	8175	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	The genes for a spliceosome protein -LRB- SAP62 -RRB- and the anti-M llerian hormone -LRB- AMH -RRB- are contiguous .
23723001	0	AMH	29,32	SCF	36,39	AMH	SCF	268	4254	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of recombinant human AMH on SCF expression in human granulosa cells .
23847299	0	AMH	30,33	anti-Mullerian_hormone	6,28	AMH	anti-Mullerian hormone	268	268	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum anti-Mullerian_hormone -LRB- AMH -RRB- levels correlate with infrarenal aortic diameter in healthy older men : is AMH a cardiovascular hormone ?
11090081	0	AML-1	0,5	ETO	6,9	AML-1	ETO	861	862	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nsubj|protein protein|compound|END_ENTITY	AML-1 / ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic_leukemia zinc finger protein .
17493351	0	AML-1	58,63	ETO	64,67	AML-1	ETO	861	862	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Immunophenotypic features of acute_myeloid_leukemia with AML-1 / ETO fusion gene -RSB- .
15720729	0	AML1	31,35	AtRaptor1B	42,52	AML1	AtRaptor1B	836317(Tax:3702)	820032(Tax:3702)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B , the plant homologue of a major regulator of eukaryotic cell growth .
14724585	0	AML1	5,9	BCR/ABL	96,103	AML1	BCR/ABL	12394(Tax:10090)	110279;11350	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Both AML1 and EVI1 oncogenic components are required for the cooperation of AML1/MDS1/EVI1 with BCR/ABL in the induction of acute_myelogenous_leukemia in mice .
11165321	0	AML1	21,25	CBFA2	26,31	AML1	CBFA2	861	861	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Amplification of the AML1 -LRB- CBFA2 -RRB- gene on ring chromosomes in a patient with acute_myeloid_leukemia and a constitutional ring chromosome 21 .
11276260	0	AML1	24,28	CBF_beta	38,46	AML1	CBF beta	861	865	Gene	Gene	START_ENTITY|dep|functions functions|compound|END_ENTITY	The leukemia-associated AML1 -LRB- Runx1 -RRB- -- CBF_beta complex functions as a DNA-induced molecular clamp .
19175988	11	AML1	1295,1299	ETO	1301,1304	AML1	ETO	861	862	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	CONCLUSIONS : The synthesized siRNAs can inhibit AML1 - ETO fusion gene expression .
11841426	0	AML1	11,15	ETV6	0,4	AML1	ETV6	861	2120	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dep|cells	ETV6 -LRB- TEL -RRB- - AML1 pre-B acute_lymphoblastic_leukaemia cells are associated with a distinct antigen-presenting phenotype .
18337762	0	AML1	107,111	Evi-1	89,94	AML1	Evi-1	12394(Tax:10090)	14013(Tax:10090)	Gene	Gene	sequence|nmod|START_ENTITY sequence|compound|END_ENTITY	AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1 .
17968322	0	AML1	28,32	LAF4	54,58	AML1	LAF4	861	3899	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of the novel AML1 fusion partner gene , LAF4 , a fusion partner of MLL , in childhood T-cell_acute_lymphoblastic_leukemia with t -LRB- 2 ; 21 -RRB- -LRB- q11 ; q22 -RRB- by bubble PCR method for cDNA .
15104277	0	AML1	36,40	RUNX1	42,47	AML1	RUNX1	861	861	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosome 21 tandem repetition and AML1 -LRB- RUNX1 -RRB- gene amplification .
23709277	0	AML1	19,23	RUNX1	25,30	AML1	RUNX1	861	861	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The Runt domain of AML1 -LRB- RUNX1 -RRB- binds a sequence-conserved RNA motif that mimics a DNA element .
12917624	0	AML1	23,27	SUV39H1	0,7	AML1	SUV39H1	861	6839	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SUV39H1 interacts with AML1 and abrogates AML1 transactivity .
8824275	0	AML1	74,78	core-binding_factor_alpha2	46,72	AML1	core-binding factor alpha2	12394(Tax:10090)	12394(Tax:10090)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Biochemical and biophysical properties of the core-binding_factor_alpha2 -LRB- AML1 -RRB- DNA-binding domain .
16287839	0	AML1	39,43	cyclin_D3	102,111	AML1	cyclin D3	861	896	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The hematopoietic transcription factor AML1 -LRB- RUNX1 -RRB- is negatively regulated by the cell cycle protein cyclin_D3 .
25727291	0	AML1/ETO	0,8	HIF1a	25,30	AML1/ETO	HIF1a	861;862	3091	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	AML1/ETO cooperates with HIF1a to promote leukemogenesis through DNMT3a transactivation .
25995376	0	AMOT	55,59	YAP	60,63	AMOT	YAP	154796	10413	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Endosomal regulation of contact inhibition through the AMOT : YAP pathway .
25919700	0	AMP-18	0,6	p21	15,18	AMP-18	p21	66283(Tax:10090)	12575(Tax:10090)	Gene	Gene	Targets|compound|START_ENTITY END_ENTITY|nsubj|Targets	AMP-18 Targets p21 to Maintain Epithelial Homeostasis .
25919700	0	AMP-18	0,6	p21	15,18	AMP-18	p21	66283(Tax:10090)	12575(Tax:10090)	Gene	Gene	Targets|compound|START_ENTITY END_ENTITY|nsubj|Targets	AMP-18 Targets p21 to Maintain Epithelial Homeostasis .
26337027	0	AMP-Activated_Protein_Kinase	15,43	AMPK	45,49	AMP-Activated Protein Kinase	AMPK	5563	5563	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	A New Role for AMP-Activated_Protein_Kinase -LRB- AMPK -RRB- in the Circadian Regulation of L-Type Voltage-Gated Calcium Channels -LRB- L-VGCCs -RRB- in Late-Stage Embryonic Retinal Photoreceptors .
25766656	0	AMP-Activated_Protein_Kinase	75,103	Manganese_Superoxide_Dismutase	21,51	AMP-Activated Protein Kinase	Manganese Superoxide Dismutase	5563	6648	Gene	Gene	Pathway|compound|START_ENTITY Expression|nmod|Pathway Expression|compound|END_ENTITY	Bavachalcone-Induced Manganese_Superoxide_Dismutase Expression through the AMP-Activated_Protein_Kinase Pathway in Human Endothelial Cells .
20659426	0	AMP-activated-protein-kinase	15,43	AMPK	45,49	AMP-activated-protein-kinase	AMPK	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of AMP-activated-protein-kinase -LRB- AMPK -RRB- in neuronal amyloidogenesis .
26635351	0	AMP-activated_Protein_Kinase	108,136	AMPK	138,142	AMP-activated Protein Kinase	AMPK	5563	5563	Gene	Gene	Modulation|nmod|START_ENTITY END_ENTITY|nsubj|Modulation	Probing the Enzyme Kinetics , Allosteric Modulation and Activation of Alpha-1 and Alpha-2 Subunit Containing AMP-activated_Protein_Kinase -LRB- AMPK -RRB- Heterotrimeric Complexes by Pharmacological and Physiological Activators .
26276392	0	AMP-activated_Protein_Kinase	0,28	Arachidonate_15-Lipoxygenase	40,68	AMP-activated Protein Kinase	Arachidonate 15-Lipoxygenase	5563	246	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	AMP-activated_Protein_Kinase Suppresses Arachidonate_15-Lipoxygenase Expression in Interleukin-4-polarized Human Macrophages .
21994478	0	AMP-activated_Protein_Kinase	123,151	Heme_Oxygenase-1	163,179	AMP-activated Protein Kinase	Heme Oxygenase-1	5563	3162	Gene	Gene	Induced|compound|START_ENTITY Activation|nmod|Induced Species|nmod|Activation Species|nmod|END_ENTITY	Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated_Protein_Kinase Induced by Heme_Oxygenase-1 .
16849326	0	AMP-activated_kinase	86,106	EGR1	68,72	AMP-activated kinase	EGR1	5563	1958	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated_kinase .
11971974	0	AMP-activated_kinase	0,20	HuR	43,46	AMP-activated kinase	HuR	5563	1994	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	AMP-activated_kinase regulates cytoplasmic HuR .
15759047	0	AMP-activated_protein_kinase	14,42	AMPK	44,48	AMP-activated protein kinase	AMPK	5563	5563	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- inhibits protein synthesis : a potential strategy to prevent the development of cardiac_hypertrophy .
16848549	0	AMP-activated_protein_kinase	18,46	AMPK	48,52	AMP-activated protein kinase	AMPK	5563	5563	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Early post-mortem AMP-activated_protein_kinase -LRB- AMPK -RRB- activation leads to phosphofructokinase-2_and _ -1 -LRB- PFK-2 and PFK-1 -RRB- phosphorylation and the development of pale , soft , and exudative -LRB- PSE -RRB- conditions in porcine longissimus muscle .
17519230	0	AMP-activated_protein_kinase	32,60	AMPK	62,66	AMP-activated protein kinase	AMPK	5562	5562	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Agonist-modulated regulation of AMP-activated_protein_kinase -LRB- AMPK -RRB- in endothelial cells .
17689496	0	AMP-activated_protein_kinase	76,104	AMPK	70,74	AMP-activated protein kinase	AMPK	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	CAPE -LRB- caffeic_acid_phenethyl_ester -RRB- stimulates glucose uptake through AMPK -LRB- AMP-activated_protein_kinase -RRB- activation in skeletal muscle cells .
20349036	0	AMP-activated_protein_kinase	42,70	AMPK	72,76	AMP-activated protein kinase	AMPK	5562	5562	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Nitric_oxide increases cyclic_GMP levels , AMP-activated_protein_kinase -LRB- AMPK -RRB- alpha1-specific activity and glucose transport in human skeletal muscle .
20686344	0	AMP-activated_protein_kinase	131,159	AMPK	161,165	AMP-activated protein kinase	AMPK	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	manner|amod|START_ENTITY manner|appos|END_ENTITY	5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside -LRB- AICAR -RRB- prevents nuclear translocation of constitutive_androstane_receptor by AMP-activated_protein_kinase -LRB- AMPK -RRB- independent manner .
21369818	0	AMP-activated_protein_kinase	104,132	AMPK	134,138	AMP-activated protein kinase	AMPK	5564	5564	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Fenofibric_acid prevents retinal_pigment_epithelium disruption induced by interleukin-1b by suppressing AMP-activated_protein_kinase -LRB- AMPK -RRB- activation .
21383016	0	AMP-activated_protein_kinase	0,28	AMPK	30,34	AMP-activated protein kinase	AMPK	5564	5564	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	AMP-activated_protein_kinase -LRB- AMPK -RRB- activation and glycogen_synthase_kinase-3b -LRB- GSK-3b -RRB- inhibition induce Ca2 + - independent deposition of tight junction components at the plasma membrane .
22333578	0	AMP-activated_protein_kinase	14,42	AMPK	44,48	AMP-activated protein kinase	AMPK	5563	5563	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- provides a metabolic barrier to reprogramming somatic cells into stem cells .
22736409	0	AMP-activated_protein_kinase	62,90	AMPK	92,96	AMP-activated protein kinase	AMPK	5563	5563	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Points of integration between the intracellular energy sensor AMP-activated_protein_kinase -LRB- AMPK -RRB- activity and the somatotroph axis function .
23712032	0	AMP-activated_protein_kinase	14,42	AMPK	44,48	AMP-activated protein kinase	AMPK	5563	5563	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon_cancer cells .
24490657	0	AMP-activated_protein_kinase	28,56	AMPK	58,62	AMP-activated protein kinase	AMPK	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Isoquercitrin activates the AMP-activated_protein_kinase -LRB- AMPK -RRB- signal pathway in rat H4IIE cells .
25497570	0	AMP-activated_protein_kinase	0,28	AMPK	30,34	AMP-activated protein kinase	AMPK	5563	5563	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	AMP-activated_protein_kinase -LRB- AMPK -RRB- activity negatively regulates chondrogenic differentiation .
26998423	0	AMP-activated_protein_kinase	70,98	AMPK	100,104	AMP-activated protein kinase	AMPK	5563	5563	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated_protein_kinase -LRB- AMPK -RRB- signaling .
22024046	0	AMP-activated_protein_kinase	111,139	Adiponectin	0,11	AMP-activated protein kinase	Adiponectin	5563	9370	Gene	Gene	pathway|amod|START_ENTITY promotes|nmod|pathway promotes|nsubj|END_ENTITY	Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan_synthase_2 transcripts through an AMP-activated_protein_kinase / peroxisome_proliferator-activated_receptor-a-dependent pathway in human dermal fibroblasts .
19639604	0	AMP-activated_protein_kinase	0,28	Akt	122,125	AMP-activated protein kinase	Akt	5563	207	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	AMP-activated_protein_kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1 / Akt signaling in C2C12 myotubes .
20019839	0	AMP-activated_protein_kinase	32,60	CCL2	0,4	AMP-activated protein kinase	CCL2	5563	6347	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	CCL2 is a negative regulator of AMP-activated_protein_kinase to sustain mTOR complex-1 activation , survivin expression , and cell survival in human prostate_cancer PC3 cells .
20881236	0	AMP-activated_protein_kinase	58,86	Calcitonin_gene-related_peptide	0,31	AMP-activated protein kinase	Calcitonin gene-related peptide	5563	796	Gene	Gene	angiogenesis|nmod|START_ENTITY promotes|dobj|angiogenesis promotes|nsubj|END_ENTITY	Calcitonin_gene-related_peptide promotes angiogenesis via AMP-activated_protein_kinase .
23291169	0	AMP-activated_protein_kinase	0,28	CtBP1	44,49	AMP-activated protein kinase	CtBP1	5563	1487	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	AMP-activated_protein_kinase phosphorylates CtBP1 and down-regulates its activity .
25065674	0	AMP-activated_protein_kinase	0,28	FoxO1	124,129	AMP-activated protein kinase	FoxO1	5563	2308	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	AMP-activated_protein_kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1 .
24815515	0	AMP-activated_protein_kinase	41,69	GLUT3	73,78	AMP-activated protein kinase	GLUT3	5563	6515	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of pharmacological inhibition of AMP-activated_protein_kinase on GLUT3 expression and the development of ischemic tolerance in astrocytes .
16105857	0	AMP-activated_protein_kinase	76,104	GLUT4_enhancer_factor	21,42	AMP-activated protein kinase	GLUT4 enhancer factor	5563	56731	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of muscle GLUT4_enhancer_factor and myocyte_enhancer_factor_2 by AMP-activated_protein_kinase .
18063581	0	AMP-activated_protein_kinase	0,28	Golgi-specific_brefeldin_A_resistance_factor_1	44,90	AMP-activated protein kinase	Golgi-specific brefeldin A resistance factor 1	5563	8729	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	AMP-activated_protein_kinase phosphorylates Golgi-specific_brefeldin_A_resistance_factor_1 at Thr1337 to induce disassembly of Golgi apparatus .
12740371	0	AMP-activated_protein_kinase	0,28	HNF4alpha	39,48	AMP-activated protein kinase	HNF4alpha	5563	3172	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	AMP-activated_protein_kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability .
11423471	0	AMP-activated_protein_kinase	110,138	Hepatocyte_nuclear_factor-4alpha	0,32	AMP-activated protein kinase	Hepatocyte nuclear factor-4alpha	5563	3172	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Hepatocyte_nuclear_factor-4alpha involved in type 1 maturity-onset diabetes_of_the_young is a novel target of AMP-activated_protein_kinase .
23180823	0	AMP-activated_protein_kinase	0,28	IFN-y	39,44	AMP-activated protein kinase	IFN-y	5563	3458	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|END_ENTITY	AMP-activated_protein_kinase restricts IFN-y signaling .
20808308	0	AMP-activated_protein_kinase	27,55	MAPK3/1	91,98	AMP-activated protein kinase	MAPK3/1	5563	5595;5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Prognostic significance of AMP-activated_protein_kinase expression and modifying effect of MAPK3/1 in colorectal_cancer .
11716464	0	AMP-activated_protein_kinase	48,76	Malonyl-CoA_decarboxylase	0,25	AMP-activated protein kinase	Malonyl-CoA decarboxylase	78975(Tax:10116)	85239(Tax:10116)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Malonyl-CoA_decarboxylase is not a substrate of AMP-activated_protein_kinase in rat fast-twitch skeletal muscle or an islet cell line .
17097062	0	AMP-activated_protein_kinase	0,28	PEPCK	39,44	AMP-activated protein kinase	PEPCK	5563	5106	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	AMP-activated_protein_kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor .
20231899	0	AMP-activated_protein_kinase	26,54	Phospholipase_D1	0,16	AMP-activated protein kinase	Phospholipase D1	5563	5337	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Phospholipase_D1 mediates AMP-activated_protein_kinase signaling for glucose uptake .
21474997	0	AMP-activated_protein_kinase	43,71	Polo-like_kinase_1	0,18	AMP-activated protein kinase	Polo-like kinase 1	5563	5347	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Polo-like_kinase_1 regulates activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- at the mitotic apparatus .
20217115	0	AMP-activated_protein_kinase	7,35	SIRT1	0,5	AMP-activated protein kinase	SIRT1	5563	23411	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	SIRT1 , AMP-activated_protein_kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise : influence of glucose ingestion .
20421294	0	AMP-activated_protein_kinase	18,46	SIRT1	112,117	AMP-activated protein kinase	SIRT1	5563	23411	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Macrophage alpha1 AMP-activated_protein_kinase -LRB- alpha1AMPK -RRB- antagonizes fatty_acid-induced inflammation through SIRT1 .
16678800	0	AMP-activated_protein_kinase	18,46	VEGF	95,99	AMP-activated protein kinase	VEGF	5563	7422	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Critical roles of AMP-activated_protein_kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145_prostate_carcinoma .
22357971	0	AMP-activated_protein_kinase	87,115	agouti-related_peptide	49,71	AMP-activated protein kinase	agouti-related peptide	5562	181	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The ketone body b-hydroxybutyric_acid influences agouti-related_peptide expression via AMP-activated_protein_kinase in hypothalamic GT1-7 cells .
21867676	0	AMP-activated_protein_kinase	0,28	aquaporin_9	62,73	AMP-activated protein kinase	aquaporin 9	5563	366	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	AMP-activated_protein_kinase modulates the gene expression of aquaporin_9 via forkhead_box_a2 .
9845345	0	AMP-activated_protein_kinase	18,46	carnitine_palmitoyltransferase_I	68,100	AMP-activated protein kinase	carnitine palmitoyltransferase I	78975(Tax:10116)	25756(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Evidence that the AMP-activated_protein_kinase stimulates rat liver carnitine_palmitoyltransferase_I by phosphorylating cytoskeletal components .
10862786	0	AMP-activated_protein_kinase	113,141	cystic_fibrosis_transmembrane_conductance_regulator	14,65	AMP-activated protein kinase	cystic fibrosis transmembrane conductance regulator	78975(Tax:10116)	24255(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cystic_fibrosis_transmembrane_conductance_regulator by novel interaction with the metabolic sensor AMP-activated_protein_kinase .
23525626	0	AMP-activated_protein_kinase	107,135	heme_oxygenase-1	86,102	AMP-activated protein kinase	heme oxygenase-1	5563	3162	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	b-Lapachone , a substrate of NAD -LRB- P -RRB- H : quinone oxidoreductase , induces anti-inflammatory heme_oxygenase-1 via AMP-activated_protein_kinase activation in RAW264 .7 macrophages .
21369818	0	AMP-activated_protein_kinase	104,132	interleukin-1b	74,88	AMP-activated protein kinase	interleukin-1b	5564	3553	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Fenofibric_acid prevents retinal_pigment_epithelium disruption induced by interleukin-1b by suppressing AMP-activated_protein_kinase -LRB- AMPK -RRB- activation .
21070787	0	AMP-activated_protein_kinase	0,28	monocarboxylate_transporter_4	57,86	AMP-activated protein kinase	monocarboxylate transporter 4	78975(Tax:10116)	80878(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	AMP-activated_protein_kinase regulates the expression of monocarboxylate_transporter_4 in skeletal muscle .
18079115	0	AMP-activated_protein_kinase	14,42	p53	121,124	AMP-activated protein kinase	p53	5563	7157	Gene	Gene	Inhibition|nmod|START_ENTITY sensitizes|nsubj|Inhibition sensitizes|nmod|apoptosis apoptosis|nmod|hyper-induction hyper-induction|nmod|END_ENTITY	Inhibition of AMP-activated_protein_kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53 .
20880848	0	AMP-activated_protein_kinase	14,42	p53	110,113	AMP-activated protein kinase	p53	5563	7157	Gene	Gene	Activation|nmod|START_ENTITY contributes|nsubj|Activation contributes|nmod|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|compound|END_ENTITY	Activation of AMP-activated_protein_kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition .
24190973	0	AMP-activated_protein_kinase	0,28	p53	37,40	AMP-activated protein kinase	p53	5563	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	AMP-activated_protein_kinase induces p53 by phosphorylating MDMX and inhibiting its activity .
26034977	0	AMP-activated_protein_kinase	51,79	p53	39,42	AMP-activated protein kinase	p53	5564	7157	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Matrine-induced autophagy regulated by p53 through AMP-activated_protein_kinase in human hepatoma cells .
26034977	0	AMP-activated_protein_kinase	51,79	p53	39,42	AMP-activated protein kinase	p53	5564	7157	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Matrine-induced autophagy regulated by p53 through AMP-activated_protein_kinase in human hepatoma cells .
20438809	0	AMP-activated_protein_kinase	0,28	peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	71,138	AMP-activated protein kinase	peroxisome proliferator-activated receptor gamma coactivator-1alpha	78975(Tax:10116)	83516(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	AMP-activated_protein_kinase mediates activity-dependent regulation of peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha and nuclear_respiratory_factor_1 expression in rat visual cortical neurons .
12065578	0	AMP-activated_protein_kinase	123,151	sn-glycerol-3-phosphate_acyltransferase	52,91	AMP-activated protein kinase	sn-glycerol-3-phosphate acyltransferase	78975(Tax:10116)	29653(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Coordinate regulation of malonyl-CoA_decarboxylase , sn-glycerol-3-phosphate_acyltransferase , and acetyl-CoA carboxylase by AMP-activated_protein_kinase in rat tissues in response to exercise .
26700142	0	AMP18	0,5	SLC26A3	41,48	AMP18	SLC26A3	56287	1811	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	AMP18 interacts with the anion exchanger SLC26A3 and enhances its expression in gastric_cancer cells .
18502715	0	AMPK	0,4	AICAR	16,21	AMPK	AICAR	5562	471	Gene	Gene	activator|compound|START_ENTITY activator|appos|END_ENTITY	AMPK activator , AICAR , inhibits palmitate-induced apoptosis in osteoblast .
24425763	0	AMPK	32,36	AICAR	71,76	AMPK	AICAR	5563	471	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Enhanced activation of cellular AMPK by dual-small molecule treatment : AICAR and A769662 .
26337027	0	AMPK	45,49	AMP-Activated_Protein_Kinase	15,43	AMPK	AMP-Activated Protein Kinase	5563	5563	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	A New Role for AMP-Activated_Protein_Kinase -LRB- AMPK -RRB- in the Circadian Regulation of L-Type Voltage-Gated Calcium Channels -LRB- L-VGCCs -RRB- in Late-Stage Embryonic Retinal Photoreceptors .
20659426	0	AMPK	45,49	AMP-activated-protein-kinase	15,43	AMPK	AMP-activated-protein-kinase	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of AMP-activated-protein-kinase -LRB- AMPK -RRB- in neuronal amyloidogenesis .
26635351	0	AMPK	138,142	AMP-activated_Protein_Kinase	108,136	AMPK	AMP-activated Protein Kinase	5563	5563	Gene	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Probing the Enzyme Kinetics , Allosteric Modulation and Activation of Alpha-1 and Alpha-2 Subunit Containing AMP-activated_Protein_Kinase -LRB- AMPK -RRB- Heterotrimeric Complexes by Pharmacological and Physiological Activators .
15759047	0	AMPK	44,48	AMP-activated_protein_kinase	14,42	AMPK	AMP-activated protein kinase	5563	5563	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- inhibits protein synthesis : a potential strategy to prevent the development of cardiac_hypertrophy .
16848549	0	AMPK	48,52	AMP-activated_protein_kinase	18,46	AMPK	AMP-activated protein kinase	5563	5563	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Early post-mortem AMP-activated_protein_kinase -LRB- AMPK -RRB- activation leads to phosphofructokinase-2_and _ -1 -LRB- PFK-2 and PFK-1 -RRB- phosphorylation and the development of pale , soft , and exudative -LRB- PSE -RRB- conditions in porcine longissimus muscle .
17519230	0	AMPK	62,66	AMP-activated_protein_kinase	32,60	AMPK	AMP-activated protein kinase	5562	5562	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Agonist-modulated regulation of AMP-activated_protein_kinase -LRB- AMPK -RRB- in endothelial cells .
17689496	0	AMPK	70,74	AMP-activated_protein_kinase	76,104	AMPK	AMP-activated protein kinase	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	CAPE -LRB- caffeic_acid_phenethyl_ester -RRB- stimulates glucose uptake through AMPK -LRB- AMP-activated_protein_kinase -RRB- activation in skeletal muscle cells .
20349036	0	AMPK	72,76	AMP-activated_protein_kinase	42,70	AMPK	AMP-activated protein kinase	5562	5562	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Nitric_oxide increases cyclic_GMP levels , AMP-activated_protein_kinase -LRB- AMPK -RRB- alpha1-specific activity and glucose transport in human skeletal muscle .
20686344	0	AMPK	161,165	AMP-activated_protein_kinase	131,159	AMPK	AMP-activated protein kinase	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	manner|appos|START_ENTITY manner|amod|END_ENTITY	5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside -LRB- AICAR -RRB- prevents nuclear translocation of constitutive_androstane_receptor by AMP-activated_protein_kinase -LRB- AMPK -RRB- independent manner .
21369818	0	AMPK	134,138	AMP-activated_protein_kinase	104,132	AMPK	AMP-activated protein kinase	5564	5564	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Fenofibric_acid prevents retinal_pigment_epithelium disruption induced by interleukin-1b by suppressing AMP-activated_protein_kinase -LRB- AMPK -RRB- activation .
21383016	0	AMPK	30,34	AMP-activated_protein_kinase	0,28	AMPK	AMP-activated protein kinase	5564	5564	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	AMP-activated_protein_kinase -LRB- AMPK -RRB- activation and glycogen_synthase_kinase-3b -LRB- GSK-3b -RRB- inhibition induce Ca2 + - independent deposition of tight junction components at the plasma membrane .
22333578	0	AMPK	44,48	AMP-activated_protein_kinase	14,42	AMPK	AMP-activated protein kinase	5563	5563	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- provides a metabolic barrier to reprogramming somatic cells into stem cells .
22736409	0	AMPK	92,96	AMP-activated_protein_kinase	62,90	AMPK	AMP-activated protein kinase	5563	5563	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Points of integration between the intracellular energy sensor AMP-activated_protein_kinase -LRB- AMPK -RRB- activity and the somatotroph axis function .
23712032	0	AMPK	44,48	AMP-activated_protein_kinase	14,42	AMPK	AMP-activated protein kinase	5563	5563	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon_cancer cells .
24490657	0	AMPK	58,62	AMP-activated_protein_kinase	28,56	AMPK	AMP-activated protein kinase	78975(Tax:10116)	78975(Tax:10116)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Isoquercitrin activates the AMP-activated_protein_kinase -LRB- AMPK -RRB- signal pathway in rat H4IIE cells .
25497570	0	AMPK	30,34	AMP-activated_protein_kinase	0,28	AMPK	AMP-activated protein kinase	5563	5563	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	AMP-activated_protein_kinase -LRB- AMPK -RRB- activity negatively regulates chondrogenic differentiation .
26998423	0	AMPK	100,104	AMP-activated_protein_kinase	70,98	AMPK	AMP-activated protein kinase	5563	5563	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated_protein_kinase -LRB- AMPK -RRB- signaling .
16613876	0	AMPK	0,4	AMPK	29,33	AMPK	AMPK	5563	5563	Gene	Gene	proliferation|compound|START_ENTITY proliferation|dep|END_ENTITY	AMPK and cell proliferation -- AMPK as a therapeutic target for atherosclerosis and cancer .
16613876	0	AMPK	29,33	AMPK	0,4	AMPK	AMPK	5563	5563	Gene	Gene	proliferation|dep|START_ENTITY proliferation|compound|END_ENTITY	AMPK and cell proliferation -- AMPK as a therapeutic target for atherosclerosis and cancer .
22960274	0	AMPK	37,41	ATM	0,3	AMPK	ATM	5562	472	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis .
26227473	0	AMPK	29,33	CaMKKb	49,55	AMPK	CaMKKb	5563	10645	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Proteasome inhibitors induce AMPK activation via CaMKKb in human breast_cancer cells .
26806558	0	AMPK	0,4	Connexin43	16,26	AMPK	Connexin43	78975(Tax:10116)	14609(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis .
26010513	0	AMPK	85,89	DPP-4	0,5	AMPK	DPP-4	5564	1803	Gene	Gene	Cytotoxicity|nmod|START_ENTITY Cytotoxicity|compound|END_ENTITY	DPP-4 Inhibitor Linagliptin Attenuates Ab-induced Cytotoxicity through Activation of AMPK in Neuronal Cells .
23479427	0	AMPK	0,4	DSCAM	20,25	AMPK	DSCAM	5563	1826	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth .
19560442	0	AMPK	48,52	FATP1	0,5	AMPK	FATP1	5563	376497	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	FATP1 mediates fatty_acid-induced activation of AMPK in 3T3-L1 adipocytes .
21097394	0	AMPK	12,16	FOXO1	52,57	AMPK	FOXO1	78975(Tax:10116)	84482(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes -RSB- .
25315694	0	AMPK	41,45	FSP27	14,19	AMPK	FSP27	5562	63924	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|stability stability|compound|END_ENTITY	Regulation of FSP27 protein stability by AMPK and HSC70 .
23418352	0	AMPK	0,4	GBF1	20,24	AMPK	GBF1	5563	8729	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	AMPK phosphorylates GBF1 for mitotic Golgi disassembly .
18435282	0	AMPK	14,18	GLUT4	30,35	AMPK	GLUT4	5563	6517	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Mechanism of AMPK regulating GLUT4 gene expression in skeletal muscle cells -RSB- .
26236947	0	AMPK	0,4	GSK3b	34,39	AMPK	GSK3b	5564	2932	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	AMPK inhibits MTDH expression via GSK3b and SIRT1 activation : potential role in triple_negative_breast_cancer cell proliferation .
23791554	0	AMPK	69,73	HIF-1a	36,42	AMPK	HIF-1a	5563	3091	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Mitochondrial dysfunction represses HIF-1a protein synthesis through AMPK activation in human hepatoma HepG2 cells .
22178220	0	AMPK	21,25	Hsp90	0,5	AMPK	Hsp90	5563	3320	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation .
20644547	0	AMPK	0,4	INS-1	125,130	AMPK	PDX-1	78975(Tax:10116)	29535(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	AMPK enhances the expression of pancreatic_duodenal_homeobox-1 via PPARalpha , but not PPARgamma , in rat_insulinoma cell line INS-1 .
24625528	0	AMPK	54,58	INS-1	74,79	AMPK	INS-1	5562	2305	Gene	Gene	AMP-activated_protein_kinase|appos|START_ENTITY analysis|nmod|AMP-activated_protein_kinase analysis|dep|_ _|dep|b1 b1|nmod|beta-cells beta-cells|amod|pancreatic pancreatic|amod|END_ENTITY	Interactome analysis of AMP-activated_protein_kinase -LRB- AMPK -RRB- - a1_and _ - b1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry .
26105159	0	AMPK	27,31	Insulin	35,42	AMPK	Insulin	5563	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|compound|END_ENTITY	The Paradoxical Effects of AMPK on Insulin Gene Expression and Glucose-Induced Insulin Secretion .
15780593	0	AMPK	25,29	LKB1	18,22	AMPK	LKB1	5563	6794	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	New roles for the LKB1 -- > AMPK pathway .
19937189	0	AMPK	60,64	LKB1	5,9	AMPK	LKB1	78975(Tax:10116)	314621(Tax:10116)	Gene	Gene	kinase|appos|START_ENTITY activation|nmod|kinase mediate|dobj|activation mediate|nsubj|END_ENTITY	Does LKB1 mediate activation of hepatic AMP-protein kinase -LRB- AMPK -RRB- and sirtuin1 -LRB- SIRT1 -RRB- after Roux-en-Y_gastric_bypass in obese rats ?
20029389	0	AMPK	83,87	LKB1	28,32	AMPK	LKB1	5563	6794	Gene	Gene	activation|compound|START_ENTITY regulation|nmod|activation controls|nmod|regulation controls|nsubj|END_ENTITY	The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression .
21145922	0	AMPK	28,32	LKB1	115,119	AMPK	LKB1	5563	6794	Gene	Gene	mediated|nmod|START_ENTITY mediated|advcl|dependent dependent|nmod|END_ENTITY	eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1 .
21872575	0	AMPK	0,4	LKB1	56,60	AMPK	LKB1	5563	6794	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|vascular vascular|dobj|senescence senescence|nmod|pathway pathway|compound|END_ENTITY	AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway .
24998845	0	AMPK	30,34	LKB1	8,12	AMPK	LKB1	5563	6794	Gene	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|isoform isoform|compound|END_ENTITY	A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties .
25874865	0	AMPK	19,23	LKB1	41,45	AMPK	LKB1	5562	6794	Gene	Gene	START_ENTITY|dobj|Independently Independently|nmod|END_ENTITY	MLK3 Phophorylates AMPK Independently of LKB1 .
25874865	0	AMPK	19,23	LKB1	41,45	AMPK	LKB1	5562	6794	Gene	Gene	START_ENTITY|dobj|Independently Independently|nmod|END_ENTITY	MLK3 Phophorylates AMPK Independently of LKB1 .
26236947	0	AMPK	0,4	MTDH	14,18	AMPK	MTDH	5564	92140	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	AMPK inhibits MTDH expression via GSK3b and SIRT1 activation : potential role in triple_negative_breast_cancer cell proliferation .
21619869	0	AMPK	0,4	MUC5B	13,18	AMPK	MUC5B	5563	727897	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells .
26845040	0	AMPK	64,68	MiR-133a	24,32	AMPK	MiR-133a	78975(Tax:10116)	100314030(Tax:10116)	Gene	Gene	Activation|compound|START_ENTITY END_ENTITY|nmod|Activation	Adiponectin Upregulates MiR-133a in Cardiac_Hypertrophy through AMPK Activation and Reduced ERK1/2 Phosphorylation .
18068666	0	AMPK	27,31	NPY	64,67	AMPK	NPY	5563	4852	Gene	Gene	i|nmod|START_ENTITY raises|dobj|i raises|nmod|neurons neurons|compound|END_ENTITY	Ghrelin raises -LSB- Ca2 + -RSB- i via AMPK in hypothalamic arcuate nucleus NPY neurons .
24693963	0	AMPK	62,66	NPY	25,28	AMPK	NPY	5563	4852	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Glucocorticoids increase NPY gene expression via hypothalamic AMPK signaling in broiler chicks .
20656472	0	AMPK	109,113	OGG1	82,86	AMPK	OGG1	5562	4968	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Novel mechanism of reducing tumourigenesis : upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition .
27051413	0	AMPK	84,88	PPARa	37,42	AMPK	PPARa	78975(Tax:10116)	25747(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Possible Role of Interaction between PPARa and Cyclophilin_D in Cardioprotection of AMPK against In Vivo_Ischemia-Reperfusion in Rats .
21813245	0	AMPK	0,4	PRKAG2	21,27	AMPK	PRKAG2	5563	51422	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	AMPK y2 subunit gene PRKAG2 polymorphism associated with cognitive_impairment as well as diabetes in old age .
22363791	0	AMPK	19,23	Sestrin2	0,8	AMPK	Sestrin2	5562	83667	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast_cancer cells .
20649096	0	AMPK	58,62	TNF_alpha	47,56	AMPK	TNF alpha	5562	7124	Gene	Gene	Pro-insulin|appos|START_ENTITY Pro-insulin|appos|END_ENTITY	Pro-insulin , _ C_peptide , glucagon , adiponectin , TNF_alpha , AMPK : neglected players in type_2_diabetes_mellitus .
25826530	0	AMPK	21,25	TSC2	61,65	AMPK	TSC2	43904(Tax:7227)	40201(Tax:7227)	Gene	Gene	Site|compound|START_ENTITY Site|nmod|END_ENTITY	Identification of an AMPK Phosphorylation Site in Drosophila TSC2 -LRB- gigas -RRB- that Regulate Cell Growth .
25122003	0	AMPK	22,26	Urocortin_3	0,11	AMPK	Urocortin 3	78975(Tax:10116)	498791(Tax:10116)	Gene	Gene	pathways|nsubj|START_ENTITY activates|ccomp|pathways activates|nsubj|END_ENTITY	Urocortin_3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle .
24179522	0	AMPK	82,86	VEGF	121,125	AMPK	VEGF	5563	7422	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Pro-apoptotic and migration-suppressing potential of EGCG , and the involvement of AMPK in the p53-mediated modulation of VEGF and MMP-9 expression .
18455514	0	AMPK	44,48	adiponectin	22,33	AMPK	adiponectin	5563	9370	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells .
20649096	0	AMPK	58,62	adiponectin	34,45	AMPK	adiponectin	5562	9370	Gene	Gene	Pro-insulin|appos|START_ENTITY Pro-insulin|appos|END_ENTITY	Pro-insulin , _ C_peptide , glucagon , adiponectin , TNF_alpha , AMPK : neglected players in type_2_diabetes_mellitus .
24167160	0	AMPK	0,4	catalase	24,32	AMPK	catalase	5562	847	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	AMPK and FoxO1 regulate catalase expression in hypoxic pulmonary arterial smooth muscle .
20686344	0	AMPK	161,165	constitutive_androstane_receptor	95,127	AMPK	constitutive androstane receptor	78975(Tax:10116)	65035(Tax:10116)	Gene	Gene	manner|appos|START_ENTITY manner|amod|END_ENTITY	5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside -LRB- AICAR -RRB- prevents nuclear translocation of constitutive_androstane_receptor by AMP-activated_protein_kinase -LRB- AMPK -RRB- independent manner .
23863634	0	AMPK	0,4	insulin	6,13	AMPK	insulin	5563	3630	Gene	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	AMPK , insulin resistance , and the metabolic_syndrome .
21369818	0	AMPK	134,138	interleukin-1b	74,88	AMPK	interleukin-1b	5564	3553	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Fenofibric_acid prevents retinal_pigment_epithelium disruption induced by interleukin-1b by suppressing AMP-activated_protein_kinase -LRB- AMPK -RRB- activation .
15328075	0	AMPK	23,27	lipoprotein_lipase	65,83	AMPK	lipoprotein lipase	78975(Tax:10116)	24539(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The metabolic `` switch '' AMPK regulates cardiac heparin-releasable lipoprotein_lipase .
12558800	0	AMPK	57,61	mTOR	98,102	AMPK	mTOR	5563	21977(Tax:10090)	Gene	Gene	AMP-activated_protein_kinase|appos|START_ENTITY AMP-activated_protein_kinase|appos|END_ENTITY	A possible linkage between AMP-activated_protein_kinase -LRB- AMPK -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling pathway .
16953221	0	AMPK	14,18	mTOR	48,52	AMPK	mTOR	5562	21977(Tax:10090)	Gene	Gene	START_ENTITY|advcl|signalling signalling|nmod|END_ENTITY	Dysfunctional AMPK activity , signalling through mTOR and survival in response to energetic stress in LKB1-deficient_lung_cancer .
19225536	0	AMPK	73,77	mTOR	50,54	AMPK	mTOR	5563	21977(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|xcomp|signaling	Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle_cell_lymphoma .
20811725	0	AMPK	123,127	mTOR	129,133	AMPK	mTOR	5562	21977(Tax:10090)	Gene	Gene	kinase|appos|START_ENTITY pathways|nsubj|kinase pathways|dep|END_ENTITY	2-Arylthiazolidine-4-carboxylic_acid_amides -LRB- ATCAA -RRB- target dual pathways in cancer cells : 5 ' - AMP-activated protein kinase -LRB- AMPK -RRB- / mTOR and PI3K/Akt/mTOR pathways .
24474794	0	AMPK	57,61	mTOR	23,27	AMPK	mTOR	5563	21977(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK .
24474794	0	AMPK	86,90	mTOR	23,27	AMPK	mTOR	5563	21977(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY agonists|dobj|independent agonists|nsubj|mechanisms mechanisms|nmod|regulation regulation|compound|END_ENTITY	Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK .
27035650	0	AMPK	38,42	mTOR	15,19	AMPK	mTOR	5563	21977(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of mTOR and regulation by AMPK in early iodine deficiency-induced thyroid microvascular activation .
20644547	0	AMPK	0,4	pancreatic_duodenal_homeobox-1	32,62	AMPK	pancreatic duodenal homeobox-1	78975(Tax:10116)	29535(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	AMPK enhances the expression of pancreatic_duodenal_homeobox-1 via PPARalpha , but not PPARgamma , in rat_insulinoma cell line INS-1 .
26344902	0	AMPK	40,44	raptor	83,89	AMPK	raptor	5563	57521	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells : Reversal by oleate is similar to metformin .
26344902	0	AMPK	40,44	raptor	83,89	AMPK	raptor	5563	57521	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells : Reversal by oleate is similar to metformin .
23171948	0	AMPKa1	75,81	miR-148b	0,8	AMPKa1	miR-148b	5562	442892	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	miR-148b functions as a tumor suppressor in pancreatic_cancer by targeting AMPKa1 .
23382195	0	AMPKa2	0,6	PARP-1	52,58	AMPKa2	PARP-1	5563	142	Gene	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6 .
26797128	0	AMPKa2	14,20	PKD1	0,4	AMPKa2	PKD1	5563	5310	Gene	Gene	START_ENTITY|nsubj|Inhibits Inhibits|compound|END_ENTITY	PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells .
26363472	0	AMPKa2	80,86	adiponectin	9,20	AMPKa2	adiponectin	5563	9370	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKa2 .
23466593	0	AMPKalpha2	46,56	eEF2	27,31	AMPKalpha2	eEF2	108079(Tax:10090)	13629(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart .
16954334	0	AMPKalpha2	8,18	hexokinase_II	65,78	AMPKalpha2	hexokinase II	108079(Tax:10090)	15277(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of AMPKalpha2 in basal , training - , and AICAR-induced GLUT4 , hexokinase_II , and mitochondrial protein expression in mouse muscle .
24970226	0	AMP_Deaminase	86,99	Histidine-Proline-Rich_Glycoprotein	12,47	AMP Deaminase	Histidine-Proline-Rich Glycoprotein	270	3273	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of Histidine-Proline-Rich_Glycoprotein as Zinc_Chaperone for Skeletal Muscle AMP_Deaminase .
8188235	0	AMT	75,78	aminomethyltransferase	46,68	AMT	aminomethyltransferase	275	275	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and chromosomal localization of the aminomethyltransferase gene -LRB- AMT -RRB- The gene for human aminomethyltransferase -LRB- AMT -RRB- , also known as the T-protein of the glycine cleavage system , was isolated from a human placental cosmid library and examined by restriction mapping , polymerase chain reaction analysis , and DNA sequencing .
11483602	0	AMY-1	0,5	S-AKAP84	94,102	AMY-1	S-AKAP84	26292	8165	Gene	Gene	localized|nsubj|START_ENTITY localized|nmod|association association|nmod|END_ENTITY	AMY-1 , a c-Myc-binding_protein , is localized in the mitochondria of sperm by association with S-AKAP84 , an anchor protein of cAMP-dependent protein kinase .
12414807	0	AMY-1	0,5	S-AKAP84	21,29	AMY-1	S-AKAP84	26292	8165	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus , respectively , and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein -LRB- AKAP -RRB- complex .
14501219	0	AN2	0,3	NG2	28,31	AN2	NG2	121021(Tax:10090)	121021(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	AN2 , the mouse homologue of NG2 , is a surface antigen on glial precursor cells implicated in control of cell migration .
10982825	0	ANB1	83,87	Mot3	30,34	ANB1	Mot3	853506(Tax:4932)	855092(Tax:4932)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of transcription factor Mot3 and chromatin in repression of the hypoxic gene ANB1 in yeast .
19318566	0	ANCCA	29,34	androgen_receptor	53,70	ANCCA	androgen receptor	29028	367	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Androgen-induced coactivator ANCCA mediates specific androgen_receptor signaling in prostate_cancer .
2956947	0	ANF	27,30	Atrial_natriuretic_factor	0,25	ANF	Atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Atrial_natriuretic_factor -LRB- ANF -RRB- levels are elevated in rats bearing rejecting heart-lung allografts .
15465036	0	ANF	58,61	Transforming_growth_factor-beta	0,31	ANF	Transforming growth factor-beta	4878	7040	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK .
11151301	0	ANF	41,44	atrial_natriuretic_factor	14,39	ANF	atrial natriuretic factor	394320(Tax:8355)	394320(Tax:8355)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of atrial_natriuretic_factor -LRB- ANF -RRB- during Xenopus cardiac development .
11895081	0	ANF	84,87	atrial_natriuretic_factor	57,82	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Pressure overload induces heterologous expression of the atrial_natriuretic_factor -LRB- ANF -RRB- gene .
1396230	0	ANF	37,40	atrial_natriuretic_factor	10,35	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor -LRB- ANF -RRB- on water homeostasis of the neonate .
1660404	0	ANF	73,76	atrial_natriuretic_factor	46,71	ANF	atrial natriuretic factor	100009087(Tax:9986)	100009087(Tax:9986)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Experimental_glaucoma significantly decreases atrial_natriuretic_factor -LRB- ANF -RRB- receptors in the ciliary processes of the rabbit eye .
16909307	0	ANF	65,68	atrial_natriuretic_factor	38,63	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	In Vivo beta-adrenergic activation of atrial_natriuretic_factor -LRB- ANF -RRB- reporter expression .
2147459	0	ANF	39,42	atrial_natriuretic_factor	12,37	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Ontogeny|appos|START_ENTITY Ontogeny|nmod|END_ENTITY	Ontogeny of atrial_natriuretic_factor -LRB- ANF -RRB- binding in various areas of the rat brain .
2177369	0	ANF	45,48	atrial_natriuretic_factor	18,43	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	-LSB- Plasma levels of atrial_natriuretic_factor -LRB- ANF -RRB- in the stroke patients after glycerol and mannitol infusion -RSB- .
2473074	0	ANF	38,41	atrial_natriuretic_factor	11,36	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_factor -LRB- ANF -RRB- on phenylephrine-triggered intra - and extracellular calcium dependent contraction in rat aorta .
2522951	0	ANF	43,46	atrial_natriuretic_factor	16,41	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of atrial_natriuretic_factor -LRB- ANF -RRB- binding sites in the central nervous system of the frog .
2524722	0	ANF	37,40	atrial_natriuretic_factor	10,35	ANF	atrial natriuretic factor	281355(Tax:9913)	281355(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor -LRB- ANF -RRB- on nicotinic acetylcholine receptor channels in bovine chromaffin cells .
2529306	0	ANF	48,51	atrial_natriuretic_factor	21,46	ANF	atrial natriuretic factor	281355(Tax:9913)	281355(Tax:9913)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of synthetic atrial_natriuretic_factor -LRB- ANF -RRB- on renin-aldosterone axis in the conscious newborn calf .
2541712	0	ANF	38,41	atrial_natriuretic_factor	11,36	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of atrial_natriuretic_factor -LRB- ANF -RRB- induced by acute airway_obstruction .
2933267	0	ANF	60,63	atrial_natriuretic_factor	33,58	ANF	atrial natriuretic factor	608289(Tax:9615)	608289(Tax:9615)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Hemodynamic effects of synthetic atrial_natriuretic_factor -LRB- ANF -RRB- in dogs with acute left_ventricular_failure .
2946294	0	ANF	54,57	atrial_natriuretic_factor	27,52	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Hypoxia-induced release of atrial_natriuretic_factor -LRB- ANF -RRB- from the isolated rat and rabbit heart .
2966342	0	ANF	77,80	atrial_natriuretic_factor	50,75	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and identification of immunoreactive atrial_natriuretic_factor -LRB- ANF -RRB- in the frog ventricle .
2973544	0	ANF	43,46	atrial_natriuretic_factor	16,41	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of the atrial_natriuretic_factor -LRB- ANF -RRB- in human ascitic fluid .
2977978	0	ANF	37,40	atrial_natriuretic_factor	10,35	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor -LRB- ANF -RRB- on the secretory activity of zona glomerulosa in sodium-restricted rats .
3158698	0	ANF	68,71	atrial_natriuretic_factor	41,66	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of immunoreactive synthetic atrial_natriuretic_factor -LRB- ANF -RRB- in the heart of various animal species .
8369269	0	ANF	76,79	atrial_natriuretic_factor	49,74	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Functional-morphological effect of the synthetic atrial_natriuretic_factor -LRB- ANF 101-126 -RRB- on the zona glomerulosa cells of adrenal cortex .
8745211	0	ANF	161,164	atrial_natriuretic_factor	134,159	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Influence of fibroblast growth factor -LRB- bFGF -RRB- and insulin-like growth factor -LRB- IGF-I -RRB- on cytoskeletal and contractile structures and on atrial_natriuretic_factor -LRB- ANF -RRB- expression in adult rat ventricular cardiomyocytes in culture .
8745272	0	ANF	81,84	atrial_natriuretic_factor	54,79	ANF	atrial natriuretic factor	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Localization of mRNA coding for the three subtypes of atrial_natriuretic_factor -LRB- ANF -RRB- receptors in rat anterior pituitary gland cells .
8762520	0	ANF	66,69	atrial_natriuretic_factor	39,64	ANF	atrial natriuretic factor	4878	4878	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Study on expression and regulation of atrial_natriuretic_factor -LRB- ANF -RRB- gene in nasal mucosa -RSB- .
26753798	0	ANG	44,47	Angiogenin	32,42	ANG	Angiogenin	283	283	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Lack of association between the Angiogenin -LRB- ANG -RRB- rs11701 polymorphism and amyotrophic_lateral_sclerosis risk : a meta-analysis .
11299848	0	ANG	28,31	angiogenin	16,26	ANG	angiogenin	283	283	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of angiogenin -LRB- ANG -RRB- in invasive_cervical_cancer and in cervical_intraepithelial_neoplasia -LRB- CIN -RRB- .
17462671	0	ANG	69,72	angiogenin	57,67	ANG	angiogenin	283	283	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variations in the coding and regulatory sequences of the angiogenin -LRB- ANG -RRB- gene are not associated to ALS -LRB- amyotrophic_lateral_sclerosis -RRB- in the Italian population .
16113073	0	ANG	0,3	phospholipase_D	18,33	ANG	phospholipase D	283	2822	Gene	Gene	stimulates|compound|START_ENTITY END_ENTITY|nsubj|stimulates	ANG II stimulates phospholipase_D through PKCzeta activation in VSMC : implications in adhesion , spreading , and hypertrophy .
25413303	0	ANGPT1	30,36	KDM3B	65,70	ANGPT1	KDM3B	284	51780	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B .
25779598	0	ANGPT2	23,29	DARPP-32	44,52	ANGPT2	DARPP-32	285	84152	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Gastric_tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis .
26483143	0	ANGPTL-4	0,8	vascular_endothelial_growth_factor	25,59	ANGPTL-4	vascular endothelial growth factor	51129	7422	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	ANGPTL-4 correlates with vascular_endothelial_growth_factor in patients with proliferative diabetic_retinopathy .
23205131	0	ANGPTL2	26,33	Angiopoietin-like_protein	0,25	ANGPTL2	Angiopoietin-like protein	26360(Tax:10090)	26360(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Angiopoietin-like_protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung_cancer .
20927337	0	ANGPTL4	117,124	angiopoietin-like_4	88,107	ANGPTL4	angiopoietin-like 4	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Decreased fat storage by Lactobacillus_paracasei is associated with increased levels of angiopoietin-like_4 protein -LRB- ANGPTL4 -RRB- .
26954186	0	ANGPTL4	54,61	angiopoietin-like_protein_4	25,52	ANGPTL4	angiopoietin-like protein 4	101104317	101104317	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	mRNA expression of ovine angiopoietin-like_protein_4 -LRB- ANGPTL4 -RRB- gene in adipose tissues .
19447061	0	ANGPTL6	41,48	angiopoietin-like_6	20,39	ANGPTL6	angiopoietin-like 6	83854	83854	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between angiopoietin-like_6 -LRB- ANGPTL6 -RRB- gene polymorphisms and metabolic_syndrome-related phenotypes in the French MONICA Study .
17142345	0	ANG_II	59,65	AT1	9,12	ANG II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor-mediated|nmod|START_ENTITY receptor-mediated|nsubj|END_ENTITY	Enhanced AT1 receptor-mediated vasocontractile response to ANG_II in endothelium-denuded aorta of obese Zucker rats .
24786827	0	ANG_II	0,6	HSF1	77,81	ANG II	HSF1	183	3297	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	ANG_II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation .
12388255	0	ANG_II	0,6	TIMP-1	17,23	ANG II	TIMP-1	24179(Tax:10116)	116510(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	ANG_II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo .
22328486	0	ANK3	34,38	ANKYRIN_3	18,27	ANK3	ANKYRIN 3	288	288	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequencing of the ANKYRIN_3 gene -LRB- ANK3 -RRB- encoding ankyrin_G in bipolar_disorder reveals a non-conservative amino_acid change in a short isoform of ankyrin_G .
20150882	0	ANKK1	47,52	DRD2	54,58	ANKK1	DRD2	255239	1813	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The association between TaqI A polymorphism of ANKK1 -LRB- DRD2 -RRB- gene and ADHD in the Czech boys aged between 6 and 13 years .
16869231	0	ANKK1	94,99	ankyrin_repeat_and_kinase_domain_containing_1	47,92	ANKK1	ankyrin repeat and kinase domain containing 1	255239	255239	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of a structural polymorphism in the ankyrin_repeat_and_kinase_domain_containing_1 -LRB- ANKK1 -RRB- gene and the activation of executive attention networks .
17949687	0	ANKRA2	77,83	AhR_repressor	53,66	ANKRA2	AhR repressor	57763	57491	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of transcriptional repression of AhR_repressor involving ANKRA2 , HDAC4 , and HDAC5 .
26820536	0	ANKRD53	0,7	DDA3	23,27	ANKRD53	DDA3	79998	84722	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis .
22580979	0	ANKRD6	46,52	ankyrin_repeat_domain_6	16,39	ANKRD6	ankyrin repeat domain 6	22881	22881	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of the ankyrin_repeat_domain_6 gene -LRB- ANKRD6 -RRB- and muscle and physical activity phenotypes among European-derived American adults .
24998259	0	ANKS3	93,98	ANKS6	62,67	ANKS3	ANKS6	124401	203286	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3 .
24998259	0	ANKS6	62,67	ANKS3	93,98	ANKS6	ANKS3	203286	124401	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3 .
22328486	0	ANKYRIN_3	18,27	ANK3	34,38	ANKYRIN 3	ANK3	288	288	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequencing of the ANKYRIN_3 gene -LRB- ANK3 -RRB- encoding ankyrin_G in bipolar_disorder reveals a non-conservative amino_acid change in a short isoform of ankyrin_G .
27062703	0	ANLN	27,31	Anillin	18,25	ANLN	Anillin	54443	54443	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Anillin -LRB- ANLN -RRB- is correlated with colorectal_cancer_progression and poor prognosis .
26584717	0	ANLN	106,110	ETV6	26,30	ANLN	ETV6	54443	2120	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression Identification|dep|role Identification|nmod|ANLN ANLN|nmod|gene gene|compound|END_ENTITY	Identification of ANLN as ETV6 partner gene in recurrent t -LRB- 7 ; 12 -RRB- -LRB- p15 ; p13 -RRB- : a possible role of deregulated ANLN expression in leukemogenesis .
26584717	0	ANLN	18,22	ETV6	26,30	ANLN	ETV6	54443	2120	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of ANLN as ETV6 partner gene in recurrent t -LRB- 7 ; 12 -RRB- -LRB- p15 ; p13 -RRB- : a possible role of deregulated ANLN expression in leukemogenesis .
19995712	0	ANLN	18,22	NBL1	0,4	ANLN	NBL1	54443	4681	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	NBL1 and anillin -LRB- ANLN -RRB- genes over-expression in pancreatic_carcinoma .
26486082	0	ANLN	104,108	miR-497	28,35	ANLN	miR-497	54443	574456	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal_carcinoma by targeting ANLN and HSPA4L .
23431153	0	ANO1	35,39	EGFR	89,93	ANO1	EGFR	55107	1956	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|activating activating|advcl|signaling signaling|nsubj|END_ENTITY	Calcium-activated chloride channel ANO1 promotes breast_cancer progression by activating EGFR and CAMK signaling .
25823819	0	ANO1	0,4	EGFR	20,24	ANO1	EGFR	55107	1956	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head_and_neck_cancer .
25385647	0	ANO1	102,106	insulin	110,117	ANO1	insulin	55107	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion .
23169617	0	ANO5	41,45	Anoctamin_5	23,34	ANO5	Anoctamin 5	203859	203859	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations in the Anoctamin_5 gene -LRB- ANO5 -RRB- associated with limb-girdle muscular_dystrophy 2L .
25630304	0	ANO6	51,55	TMEM16F	57,64	ANO6	TMEM16F	196527	196527	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Selective serotonin reuptake inhibitors facilitate ANO6 -LRB- TMEM16F -RRB- current activation and phosphatidylserine exposure .
1645936	0	ANP	49,52	125I-atrial_natriuretic_peptide	16,47	ANP	125I-atrial natriuretic peptide	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of 125I-atrial_natriuretic_peptide -LRB- ANP -RRB- in the rat fetus .
1533606	0	ANP	114,117	Atrial_natriuretic_peptide	0,26	ANP	Atrial natriuretic peptide	4878	4878	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Atrial_natriuretic_peptide -LRB- ANP -RRB- in chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- : the relationship between plasma ANP and lung function .
12270761	0	ANP	54,57	atrial_natriuretic_peptide	26,52	ANP	atrial natriuretic peptide	4878	4878	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Locally different role of atrial_natriuretic_peptide -LRB- ANP -RRB- in the pericardial fluid .
14501129	0	ANP	82,85	atrial_natriuretic_peptide	54,80	ANP	atrial natriuretic peptide	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Crystallization and preliminary X-ray analysis of the atrial_natriuretic_peptide -LRB- ANP -RRB- receptor extracellular domain complex with ANP : use of ammonium_sulfate as the cryosalt .
1533382	1	ANP	133,136	atrial_natriuretic_peptide	105,131	ANP	atrial natriuretic peptide	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects on atrial_natriuretic_peptide -LRB- ANP -RRB- release .
17110362	0	ANP	149,152	atrial_natriuretic_peptide	121,147	ANP	atrial natriuretic peptide	4878	4878	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Normalization of thyroid hormone levels in patients with either hyper - _ or_hypothyroidism results in a profound change of atrial_natriuretic_peptide -LRB- ANP -RRB- levels .
1839083	0	ANP	86,89	atrial_natriuretic_peptide	58,84	ANP	atrial natriuretic peptide	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Effect of adrenal cortical hormones on the expression of atrial_natriuretic_peptide -LRB- ANP -RRB- gene in vivo -RSB- .
1846877	0	ANP	81,84	atrial_natriuretic_peptide	53,79	ANP	atrial natriuretic peptide	4878	4878	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Solubilization and molecular characterization of the atrial_natriuretic_peptide -LRB- ANP -RRB- receptor in human platelets : comparison with ANP receptors in rat tissues .
2137425	0	ANP	48,51	atrial_natriuretic_peptide	20,46	ANP	atrial natriuretic peptide	100009087(Tax:9986)	100009087(Tax:9986)	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Plasmatic levels of atrial_natriuretic_peptide -LRB- ANP -RRB- in drowning .
2146055	0	ANP	36,39	atrial_natriuretic_peptide	8,34	ANP	atrial natriuretic peptide	4878	4878	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	-LSB- Plasma atrial_natriuretic_peptide -LRB- ANP -RRB- levels in Parkinson 's _ disease -- with special reference to foot edema -RSB- .
2441981	0	ANP	52,55	atrial_natriuretic_peptide	24,50	ANP	atrial natriuretic peptide	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The characterization of atrial_natriuretic_peptide -LRB- ANP -RRB- expression by primary cultures of atrial myocytes using an ANP-specific monoclonal antibody and an ANP messenger ribonucleic acid probe .
2526450	0	ANP	39,42	atrial_natriuretic_peptide	11,37	ANP	atrial natriuretic peptide	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_peptide -LRB- ANP -RRB- on jejunal net fluid absorption in the rat .
2943281	0	ANP	63,66	atrial_natriuretic_peptide	35,61	ANP	atrial natriuretic peptide	281355(Tax:9913)	281355(Tax:9913)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and activity profiles of atrial_natriuretic_peptide -LRB- ANP -RRB- analogs with reduced ring size .
2963186	0	ANP	49,52	atrial_natriuretic_peptide	21,47	ANP	atrial natriuretic peptide	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	The concentration of atrial_natriuretic_peptide -LRB- ANP -RRB- is decreased in plasma but not in atria in hypophysectomised rats .
7889288	0	ANP	59,62	atrial_natriuretic_peptide	31,57	ANP	atrial natriuretic peptide	4878	4878	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	The interaction of alpha-human atrial_natriuretic_peptide -LRB- ANP -RRB- with salbutamol , sodium_nitroprusside and isosorbide_dinitrate in human bronchial smooth muscle .
9248576	0	ANP	62,65	atrial_natriuretic_peptide	34,60	ANP	atrial natriuretic peptide	4878	4878	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of atrial_natriuretic_peptide -LRB- ANP -RRB- in the conducting system and internodal atrial myocardium of human hearts .
19328828	0	ANP	36,39	histamine_H2_receptor	52,73	ANP	histamine H2 receptor	100009087(Tax:9986)	100338726(Tax:9986)	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Cardiac mast cells regulate myocyte ANP release via histamine_H2_receptor in beating rabbit atria .
9622151	0	ANP	15,18	vitamin_D_receptor	50,68	ANP	vitamin D receptor	4878	7421	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Suppression of ANP gene transcription by liganded vitamin_D_receptor : involvement of specific receptor domains .
9080425	0	ANP-B	78,83	atrial_natriuretic_peptide	50,76	ANP-B	atrial natriuretic peptide	116564(Tax:10116)	116564(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Detection of C-type natriuretic peptide -LRB- CNP -RRB- and atrial_natriuretic_peptide -LRB- ANP-B -RRB- receptor mRNAs in rat inner ear .
21636789	0	ANP32	37,42	Acidic_nuclear_phosphoprotein_32kDa	0,35	ANP32	Acidic nuclear phosphoprotein 32kDa	11737(Tax:10090)	11737(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Acidic_nuclear_phosphoprotein_32kDa -LRB- ANP32 -RRB- B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development .
26918356	0	ANP32A	48,54	Acidic_leucine-rich_nuclear_phosphoprotein-32A	0,46	ANP32A	Acidic leucine-rich nuclear phosphoprotein-32A	8125	8125	Gene	Gene	association|appos|START_ENTITY association|amod|END_ENTITY	Acidic_leucine-rich_nuclear_phosphoprotein-32A -LRB- ANP32A -RRB- association with lymph_node_metastasis predicts poor survival in oral_squamous_cell_carcinoma patients .
21317927	0	ANP32A	43,49	MicroRNA-21	0,11	ANP32A	MicroRNA-21	8125	406991	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4 .
21152064	0	ANP32A	6,12	pp32	0,4	ANP32A	pp32	8125	8125	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	pp32 -LRB- ANP32A -RRB- expression inhibits pancreatic_cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs .
23813974	0	ANRIL	25,30	ADIPOR1	127,134	ANRIL	ADIPOR1	100048912	51094	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The large non-coding RNA ANRIL , which is associated with atherosclerosis , periodontitis and several forms of cancer , regulates ADIPOR1 , VAMP3 and C11ORF10 .
24385277	0	ANRIL	34,39	CARD8	14,19	ANRIL	CARD8	100048912	22900	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 -LRB- p.C10X -RRB- with ischemic_stroke .
24747824	0	ANRIL	0,5	TGFb1	38,43	ANRIL	TGFb1	100048912	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	ANRIL inhibits p15 -LRB- INK4b -RRB- through the TGFb1 signaling pathway in human esophageal_squamous_cell_carcinoma .
21151178	0	ANRIL	20,25	p15	83,86	ANRIL	p15	100048912	1030	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|gene gene|dep|silencing silencing|nmod|END_ENTITY	Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 -LRB- INK4B -RRB- tumor suppressor gene .
24747824	0	ANRIL	0,5	p15	15,18	ANRIL	p15	100048912	1030	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	ANRIL inhibits p15 -LRB- INK4b -RRB- through the TGFb1 signaling pathway in human esophageal_squamous_cell_carcinoma .
19425506	0	ANT1	44,48	PEO1	62,66	ANT1	PEO1	291	56652	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	-LSB- Association of the T -LRB- -365 -RRB- C POLG1 , G -LRB- -25 -RRB- A ANT1 and G -LRB- -605 -RRB- T PEO1 gene polymorphisms with diabetic_polyneuropathy in patients with type_1_diabetes_mellitus -RSB- .
22042284	0	ANTXR2	32,38	CMG2	40,44	ANTXR2	CMG2	118429	118429	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel splice site mutation in ANTXR2 -LRB- CMG2 -RRB- gene results in systemic_hyalinosis .
25682742	0	ANUBL1	64,70	MicroRNA-182	0,12	ANUBL1	MicroRNA-182	93550	406958	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric_cancer .
1830024	0	ANX3	51,55	annexin_III	38,49	ANX3	annexin III	306	306	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal localization of the human annexin_III -LRB- ANX3 -RRB- gene .
8276419	0	ANX3	54,58	annexin_III	41,52	ANX3	annexin III	306	306	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and polymorphisms of the human annexin_III -LRB- ANX3 -RRB- gene .
1346776	0	ANX4	45,49	annexin_IV	33,43	ANX4	annexin IV	307	307	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal mapping of the human annexin_IV -LRB- ANX4 -RRB- gene .
8034319	0	ANX5	37,41	annexin_V	26,35	ANX5	annexin V	308	308	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Organization of the human annexin_V -LRB- ANX5 -RRB- gene .
25056970	0	ANXA11	13,19	A11	8,11	ANXA11	A11	311	8248	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Annexin A11 -LRB- ANXA11 -RRB- gene polymorphisms are associated with sarcoidosis in a Han Chinese population : a case-control study .
26908448	0	ANXA11	0,6	c-Jun	140,145	ANXA11	c-Jun	11744(Tax:10090)	16476(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	ANXA11 regulates the tumorigenesis , lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun .
19652881	0	ANXA5	32,37	annexin_A5	20,30	ANXA5	annexin A5	308	308	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotype M2 in the annexin_A5 -LRB- ANXA5 -RRB- gene and the occurrence of obstetric complications .
20079508	0	ANXA9	27,32	annexin_9	11,20	ANXA9	annexin 9	528055(Tax:9913)	528055(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The bovine annexin_9 gene -LRB- ANXA9 -RRB- is significantly associated with milk-fat yield in a Spanish Holstein-Friesian population .
16815140	0	AOAH	57,61	acyloxyacyl_hydroxylase	32,55	AOAH	acyloxyacyl hydroxylase	313	313	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms in the novel gene acyloxyacyl_hydroxylase -LRB- AOAH -RRB- are associated with asthma and associated phenotypes .
11562361	0	AOH1	48,52	aldehyde_oxidase_homolog_1	20,46	AOH1	aldehyde oxidase homolog 1	71724(Tax:10090)	71724(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Purification of the aldehyde_oxidase_homolog_1 -LRB- AOH1 -RRB- protein and cloning of the AOH1 and aldehyde_oxidase_homolog_2 -LRB- AOH2 -RRB- genes .
11562361	0	AOH2	118,122	aldehyde_oxidase_homolog_2	90,116	AOH2	aldehyde oxidase homolog 2	71872(Tax:10090)	71872(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Purification of the aldehyde_oxidase_homolog_1 -LRB- AOH1 -RRB- protein and cloning of the AOH1 and aldehyde_oxidase_homolog_2 -LRB- AOH2 -RRB- genes .
24996175	0	AOX1	46,50	aldehyde_oxidase	28,44	AOX1	aldehyde oxidase	11761(Tax:10090)	11761(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expressional studies of the aldehyde_oxidase -LRB- AOX1 -RRB- gene during myogenic differentiation in C2C12 cells .
11431474	0	AP-1	66,70	AP-1	87,91	AP-1	AP-1	3725	3725	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA .
11431474	0	AP-1	87,91	AP-1	66,70	AP-1	AP-1	3725	3725	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	Ten ERK-related proteins in three distinct classes associate with AP-1 proteins and/or AP-1 DNA .
26814129	0	AP-1	92,96	Activator_Protein_1	71,90	AP-1	Activator Protein 1	3727	3727	Gene	Gene	Factor|appos|START_ENTITY Factor|amod|END_ENTITY	Megakaryocytic Maturation in Response to Shear Flow is Mediated by the Activator_Protein_1 -LRB- AP-1 -RRB- Transcription Factor via Mitogen-Activated Protein Kinase -LRB- MAPK -RRB- Mechanotransduction .
22092038	0	AP-1	21,25	Activator_protein-1	0,19	AP-1	Activator protein-1	3725	3725	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Activator_protein-1 -LRB- AP-1 -RRB- signalling in human atherosclerosis : results of a systematic evaluation and intervention study .
14521934	0	AP-1	28,32	Angiotensin_II	0,14	AP-1	Angiotensin II	24516(Tax:10116)	24179(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Angiotensin_II induction of AP-1 in neurons requires stimulation of PI3-K and JNK .
19465003	0	AP-1	94,98	Angiotensin_II	0,14	AP-1	Angiotensin II	3727	183	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Angiotensin_II induces type I collagen gene expression in human dermal fibroblasts through an AP-1 / TGF-beta1-dependent pathway .
9207128	0	AP-1	61,65	Angiotensin_II	0,14	AP-1	Angiotensin II	3727	183	Gene	Gene	participate|nsubj|START_ENTITY type1a|parataxis|participate type1a|nsubj|END_ENTITY	Angiotensin_II type1a receptor gene expression in the heart : AP-1 and GATA-4 participate in the response to pressure overload .
24819963	0	AP-1	82,86	Bax	53,56	AP-1	Bax	24516(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
17026529	0	AP-1	41,45	Bcl-2	134,139	AP-1	Bcl-2	24516(Tax:10116)	24224(Tax:10116)	Gene	Gene	complexes|compound|START_ENTITY generate|dobj|complexes generate|nmod|pathway pathway|dep|involvement involvement|nmod|c-Fos c-Fos|nmod|expression expression|compound|END_ENTITY	PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway : involvement of c-Fos in PACAP-induced Bcl-2 expression .
24819963	0	AP-1	82,86	Bcl-2	58,63	AP-1	Bcl-2	24516(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
22331067	0	AP-1	53,57	CD4	89,92	AP-1	CD4	3726	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	IkB kinase b is required for activation of NF-kB and AP-1 in CD3/CD28-stimulated primary CD4 -LRB- + -RRB- T cells .
9580241	0	AP-1	99,103	CD69	53,57	AP-1	CD69	3725	969	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1 .
26557810	0	AP-1	27,31	CD99	14,18	AP-1	CD99	3726	4267	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226 .
21034562	0	AP-1	135,139	CMTM2	14,19	AP-1	CMTM2	3725	146225	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	Intracellular CMTM2 negatively regulates human_immunodeficiency_virus_type-1 transcription through targeting the transcription factors AP-1 and CREB .
15530430	0	AP-1	16,20	COBRA1	0,6	AP-1	COBRA1	3725	25920	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	COBRA1 inhibits AP-1 transcriptional activity in transfected cells .
15639337	2	AP-1	164,168	COX-2	132,137	AP-1	COX-2	16476(Tax:10090)	17709(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	on phorbol_ester-induced COX-2 expression in mouse skin : AP-1 and CREB as potential upstream targets .
18192694	0	AP-1	81,85	COX-2	45,50	AP-1	COX-2	3727	5743	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|dobj|expression expression|compound|END_ENTITY	15-Deoxy-Delta12 ,14 - prostaglandin_J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast_cancer cells : a potential role of ROS .
11976688	0	AP-1	0,4	CREB	27,31	AP-1	CREB	36057(Tax:7227)	39682(Tax:7227)	Gene	Gene	functions|compound|START_ENTITY upstream|nsubj|functions upstream|nmod|END_ENTITY	AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila .
24819963	0	AP-1	82,86	CREB	88,92	AP-1	CREB	24516(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
23028371	0	AP-1	88,92	CSB-PGBD3	63,72	AP-1	CSB-PGBD3	3725	101243544	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans .
11382925	0	AP-1	28,32	Carbonic_anhydrase_II	0,21	AP-1	Carbonic anhydrase II	3727	760	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Carbonic_anhydrase_II is an AP-1 target gene in osteoclasts .
8943419	0	AP-1	66,70	Cross-linking_of_intercellular_adhesion_molecule_1	0,50	AP-1	Cross-linking of intercellular adhesion molecule 1	3725	3383	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Cross-linking_of_intercellular_adhesion_molecule_1 -LRB- CD54 -RRB- induces AP-1 activation and IL-1beta transcription .
25484988	0	AP-1	28,32	Cyclosporin_A	52,65	AP-1	Cyclosporin A	16476(Tax:10090)	71991(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Signaling Signaling|compound|END_ENTITY	Enhancement of Flow-Induced AP-1 Gene Expression by Cyclosporin_A Requires NFAT-Independent Signaling in Bone Cells .
9879517	0	AP-1	55,59	Cyclosporin_A	0,13	AP-1	Cyclosporin A	3725	1161	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Cyclosporin_A inhibits collagenase gene expression via AP-1 and JNK suppression in human gingival fibroblasts .
17471497	0	AP-1	168,172	ERK1/2	121,127	AP-1	ERK1/2	3725	5595;5594	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2 - and p38 kinase-dependent activation of AP-1 .
17504975	0	AP-1	36,40	ERK1/2	22,28	AP-1	ERK1/2	24516(Tax:10116)	50689;116590	Gene	Gene	factor|compound|START_ENTITY END_ENTITY|nmod|factor	Sequential actions of ERK1/2 on the AP-1 transcription factor allow temporal integration of metabolic signals in pancreatic beta cells .
24265756	0	AP-1	15,19	ETB	64,67	AP-1	ETB	3725	1910	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of AP-1 and C/EBPb in upregulation of endothelin B -LRB- ETB -RRB- receptor expression in a rodent model of glaucoma .
22417306	0	AP-1	26,30	ErbB	3,7	AP-1	ErbB	3726	1956	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	An ErbB receptor-mediated AP-1 regulatory network is modulated by STAT3 and c-MYC during calcium-dependent keratinocyte differentiation .
23331079	0	AP-1	47,51	FGF2	80,84	AP-1	FGF2	3726	2247	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Interleukin-1b enhances cell migration through AP-1 and NF-kB pathway-dependent FGF2 expression in human corneal endothelial cells .
22235402	0	AP-1	48,52	FOSL1	53,58	AP-1	FOSL1	3725	8061	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Effects of expression of transcriptional factor AP-1 FOSL1 gene on psoriatic process .
11756554	0	AP-1	54,58	Fra-1	19,24	AP-1	Fra-1	16476(Tax:10090)	14283(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently .
10987819	0	AP-1	30,34	Fra-2	141,146	AP-1	Fra-2	24516(Tax:10116)	25446(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY depends|nsubj|activity depends|nmod|END_ENTITY	Circadian binding activity of AP-1 , a regulator of the arylalkylamine_N-acetyltransferase gene in the rat pineal gland , depends on circadian Fra-2 , c-Jun , and Jun-D expression and is regulated by the clock 's zeitgebers .
20837772	0	AP-1	6,10	Fra-2	0,5	AP-1	Fra-2	16476(Tax:10090)	14284(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	Fra-2 / AP-1 controls bone formation by regulating osteoblast differentiation and collagen production .
24464219	0	AP-1	6,10	Fra-2	0,5	AP-1	Fra-2	16476(Tax:10090)	14284(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	Fra-2 / AP-1 controls adipocyte differentiation and survival by regulating PPARy and hypoxia .
20946255	0	AP-1	20,24	GFAP	48,52	AP-1	GFAP	3726	2670	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|compound|END_ENTITY	A novel polymorphic AP-1 binding element of the GFAP promoter is associated with different allelic transcriptional activities .
14973137	0	AP-1	40,44	GGA1	0,4	AP-1	GGA1	3727	26088	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region .
15592508	0	AP-1	22,26	HBZ	7,10	AP-1	HBZ	3725	3050	Gene	Gene	activity|compound|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein .
9688322	0	AP-1	19,23	IFN-gamma	0,9	AP-1	IFN-gamma	3726	3458	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	IFN-gamma inhibits AP-1 binding activity in human brain-derived cells through a nitric_oxide dependent mechanism .
15142264	0	AP-1	10,14	IL-1beta	110,118	AP-1	IL-1beta	3726	3553	Gene	Gene	cytokines|nsubj|START_ENTITY cytokines|dobj|END_ENTITY	Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta , tumor_necrosis_factor_alpha and IL-17 in rheumatoid synoviocytes .
17384281	0	AP-1	58,62	IL-8	83,87	AP-1	IL-8	3725	3576	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Role of mitogen-activated protein kinases , NF-kappaB , and AP-1 on cerulein-induced IL-8 expression in pancreatic acinar cells .
1437149	0	AP-1	0,4	IP-1	29,33	AP-1	IP-1	16476(Tax:10090)	8517	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	AP-1 -LRB- Fos-Jun -RRB- regulation by IP-1 : effect of signal transduction pathways and cell growth .
8641346	0	AP-1	72,76	Interferon-gamma	0,16	AP-1	Interferon-gamma	2353	3458	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Interferon-gamma modulates the lipopolysaccharide-induced expression of AP-1 and NF-kappa_B at the mRNA and protein level in human monocytes .
2799385	0	AP-1	71,75	Interleukin-1	0,13	AP-1	Interleukin-1	2353	3552	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1 .
15207247	0	AP-1	116,120	Interleukin-8	0,13	AP-1	Interleukin-8	3727	3576	Gene	Gene	pathways|compound|START_ENTITY mediated|nmod|pathways mediated|nsubjpass|production production|amod|END_ENTITY	Interleukin-8 production by THP-1 cells stimulated by Salmonella_enterica_serovar_Typhimurium porins is mediated by AP-1 , NF-kappaB and MAPK pathways .
20214788	0	AP-1	4,8	JDP2	28,32	AP-1	JDP2	16476(Tax:10090)	81703(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The AP-1 repressor protein , JDP2 , potentiates hepatocellular_carcinoma in mice .
23612584	0	AP-1	14,18	JDP2	32,36	AP-1	JDP2	16476(Tax:10090)	81703(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|overexpression overexpression|compound|END_ENTITY	Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction .
10602419	0	AP-1	79,83	JEM-1	0,5	AP-1	JEM-1	3725	8548	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	JEM-1 , a novel nuclear co-factor : localisation and functional interaction with AP-1 .
2497053	0	AP-1	69,73	Jun	84,87	AP-1	Jun	24516(Tax:10116)	24516(Tax:10116)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The product of a fos-related gene , fra-1 , binds cooperatively to the AP-1 site with Jun : transcription factor AP-1 is comprised of multiple protein complexes .
15563473	0	AP-1	64,68	JunD	77,81	AP-1	JunD	16476(Tax:10090)	16478(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor , JunD .
16157375	0	AP-1	47,51	JunD	73,77	AP-1	JunD	3727	3727	Gene	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines .
12734209	0	AP-1	21,25	Leptin	0,6	AP-1	Leptin	2354	3952	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Leptin enhances , via AP-1 , expression of aromatase in the MCF-7 cell line .
10935492	0	AP-1	146,150	MMP-9	163,168	AP-1	MMP-9	2353	4318	Gene	Gene	site|compound|START_ENTITY site|nmod|promoter promoter|compound|END_ENTITY	Transcriptional inhibition of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity by a c-fos/estrogen _ receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion .
10935492	0	AP-1	146,150	MMP-9	58,63	AP-1	MMP-9	2353	4318	Gene	Gene	site|compound|START_ENTITY mediated|nmod|site mediated|nsubjpass|inhibition inhibition|nmod|activity activity|appos|END_ENTITY	Transcriptional inhibition of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity by a c-fos/estrogen _ receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion .
17936676	0	AP-1	54,58	MMP-9	15,20	AP-1	MMP-9	3725	4318	Gene	Gene	activation|nmod|START_ENTITY increases|nmod|activation increases|dobj|expression expression|compound|END_ENTITY	Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous_carcinoma cells .
25200491	0	AP-1	56,60	MMP-9	14,19	AP-1	MMP-9	3726	4318	Gene	Gene	START_ENTITY|dep|induces induces|dobj|production production|compound|END_ENTITY	FSL-1 induces MMP-9 production through TLR-2 and NF-kB / AP-1 signaling pathways in monocytic THP-1 cells .
25875631	0	AP-1	69,73	MMP-9	40,45	AP-1	MMP-9	3725	4318	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
25875631	0	AP-1	69,73	MMP-9	40,45	AP-1	MMP-9	3725	4318	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
24819963	0	AP-1	82,86	NFk-B	75,80	AP-1	NFk-B	24516(Tax:10116)	81736(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
19499154	0	AP-1	14,18	NGX6	0,4	AP-1	NGX6	2353	51754	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin_D1 in human colorectal_cancer .
15067018	0	AP-1	31,35	PI-3K	0,5	AP-1	PI-3K	16476(Tax:10090)	18708(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY mediators|nmod|induction mediators|nsubj|END_ENTITY	PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells .
20941752	0	AP-1	48,52	PI-3K	42,47	AP-1	PI-3K	3727	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Silica induces cell cycle changes through PI-3K / AP-1 pathway in human embryo lung fibroblast cells .
12552119	0	AP-1	37,41	Ref-1	31,36	AP-1	Ref-1	3726	328	Gene	Gene	identification|dep|START_ENTITY identification|nmod|END_ENTITY	Chemogenomic identification of Ref-1 / AP-1 as a therapeutic target for asthma .
22067914	0	AP-1	33,37	S1P1	10,14	AP-1	S1P1	16476(Tax:10090)	13609(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	CCR7 with S1P1 signaling through AP-1 for migration of Foxp3 + regulatory T-cells controls autoimmune exocrinopathy .
18055217	0	AP-1	17,21	SOCS3	0,5	AP-1	SOCS3	3726	9021	Gene	Gene	activity|compound|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun_N-terminal_kinase .
15579469	0	AP-1	76,80	Smad7	32,37	AP-1	Smad7	3725	4092	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts .
19057013	0	AP-1	19,23	Sulfiredoxin	0,12	AP-1	Sulfiredoxin	3725	140809	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin_malignancies .
16135795	0	AP-1	12,16	TERT	80,84	AP-1	TERT	3725	7015	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Function of AP-1 in transcription of the telomerase_reverse_transcriptase_gene -LRB- TERT -RRB- in human and mouse cells .
20032511	0	AP-1	46,50	Thrombin	0,8	AP-1	Thrombin	24516(Tax:10116)	29251(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Thrombin induces endothelial arginase through AP-1 activation .
14608369	0	AP-1	0,4	VAMP4	20,25	AP-1	VAMP4	16476(Tax:10090)	53330(Tax:10090)	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 .
8386622	0	AP-1	153,157	activator-protein-1	132,151	AP-1	activator-protein-1	3725	3725	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Synergism between protein-kinase C and cAMP-dependent pathways in the expression of the interleukin-1_beta gene is mediated via the activator-protein-1 -LRB- AP-1 -RRB- enhancer activity .
11230805	0	AP-1	83,87	activator_protein-1	62,81	AP-1	activator protein-1	24516(Tax:10116)	24516(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Tissue-specific regulation of glutathione homeostasis and the activator_protein-1 -LRB- AP-1 -RRB- response in the rat conceptus .
12757717	0	AP-1	154,158	activator_protein-1	133,152	AP-1	activator protein-1	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	New unusual iridoids from the leaves of noni -LRB- Morinda citrifolia L. -RRB- show inhibitory effect on ultraviolet B-induced transcriptional activator_protein-1 -LRB- AP-1 -RRB- activity .
8001557	0	AP-1	35,39	activator_protein-1	14,33	AP-1	activator protein-1	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Modulation of activator_protein-1 -LRB- AP-1 -RRB- transcription factor and protein kinase C by hydrogen_peroxide and D-alpha-tocopherol in vascular smooth muscle cells .
9254885	0	AP-1	36,40	activator_protein-1	15,34	AP-1	activator protein-1	3727	3727	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of activator_protein-1 -LRB- AP-1 -RRB- in induction of apoptosis by vitamin_E_succinate in human breast_cancer cells .
9334204	0	AP-1	57,61	activator_protein-1	36,55	AP-1	activator protein-1	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of ultraviolet B-induced activator_protein-1 -LRB- AP-1 -RRB- activity by aspirin in AP-1-luciferase transgenic_mice .
15480426	0	AP-1	43,47	activator_protein_1	22,41	AP-1	activator protein 1	3725	3725	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Thioredoxin modulates activator_protein_1 -LRB- AP-1 -RRB- activity and p27Kip1 degradation through direct interaction with Jab1 .
21940623	0	AP-1	157,161	activator_protein_1	136,155	AP-1	activator protein 1	3725	3725	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Prostaglandin_E2 induces matrix_metalloproteinase_9 expression in dendritic cells through two independent signaling pathways leading to activator_protein_1 -LRB- AP-1 -RRB- activation .
17287278	0	AP-1	104,108	angiopoietin-2	74,88	AP-1	angiopoietin-2	3725	285	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1 .
11399048	0	AP-1	89,93	c-Jun	57,62	AP-1	c-Jun	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Nitric_oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation .
15989974	0	AP-1	25,29	c-Jun	12,17	AP-1	c-Jun	3725	3725	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates .
21757709	0	AP-1	102,106	cAMP_response_element_modulator	17,48	AP-1	cAMP response element modulator	2353	1390	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|promoter promoter|compound|END_ENTITY	A novel intronic cAMP_response_element_modulator -LRB- CREM -RRB- promoter is regulated by activator_protein-1 -LRB- AP-1 -RRB- and accounts for altered activation-induced CREM expression in T cells from patients with systemic_lupus_erythematosus .
21135252	0	AP-1	0,4	cyclin_D1	15,24	AP-1	cyclin D1	3725	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	AP-1 regulates cyclin_D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition : role of AIP4/Itch-mediated JUNB degradation .
17919072	0	AP-1	110,114	endothelial_nitric_oxide_synthase	36,69	AP-1	endothelial nitric oxide synthase	280831(Tax:9913)	287024(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	Nordihydroguaiaretic_acid increases endothelial_nitric_oxide_synthase expression via the transcription factor AP-1 .
12003967	0	AP-1	105,109	interleukin-8	53,66	AP-1	interleukin-8	3726	3576	Gene	Gene	factors|amod|START_ENTITY lipopolysaccharide-induced|nmod|factors lipopolysaccharide-induced|dobj|production production|amod|END_ENTITY	Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa_B transcription factors .
18692129	0	AP-1	78,82	interleukin-8	50,63	AP-1	interleukin-8	3727	3576	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Superoxide_dismutase attenuates hyperoxia-induced interleukin-8 induction via AP-1 .
21135252	0	AP-1	0,4	mTOR	91,95	AP-1	mTOR	3725	21977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	AP-1 regulates cyclin_D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition : role of AIP4/Itch-mediated JUNB degradation .
10580057	0	AP-1	79,83	nef	91,94	AP-1	nef	3725	156110(Tax:11676)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Lack of negative influence on the cellular transcription factors NF-kappaB and AP-1 by the nef protein of human_immunodeficiency_virus_type_1 .
23818969	0	AP-1	36,40	p21-activated_kinase_3	0,22	AP-1	p21-activated kinase 3	16476(Tax:10090)	18481(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	p21-activated_kinase_3 -LRB- PAK3 -RRB- is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts .
3135941	0	AP-1	71,75	p39	24,27	AP-1	p39	3725	3725	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	fos-associated cellular p39 is related to nuclear transcription factor AP-1 .
19234347	0	AP-1	120,124	rhodopsin	76,85	AP-1	rhodopsin	609429(Tax:9615)	493763(Tax:9615)	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Steroids do not prevent photoreceptor_degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition .
14636996	0	AP-2	78,82	AP-2_epsilon	42,54	AP-2	AP-2 epsilon	7020	339488	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Molecular cloning and characterization of AP-2_epsilon , a fifth member of the AP-2 family .
15305293	0	AP-2	49,53	AP-2_epsilon	76,88	AP-2	AP-2 epsilon	21418(Tax:10090)	332937(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Identification and embryonic expression of a new AP-2 transcription factor , AP-2_epsilon .
11522791	0	AP-2	46,50	AP-2delta	73,82	AP-2	AP-2delta	21418(Tax:10090)	226896(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Cloning and characterization of a novel mouse AP-2 transcription factor , AP-2delta , with unique DNA binding and transactivation properties .
21134476	0	AP-2	25,29	CXCL1	42,47	AP-2	CXCL1	7020	2919	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The transcription factor AP-2 regulates CXCL1 during cartilage development and in osteoarthritis .
9867351	0	AP-2	54,58	DAP-2	0,5	AP-2	DAP-2	40398(Tax:7227)	40398(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	DAP-2 , the Drosophila homolog of transcription factor AP-2 .
11247302	0	AP-2	80,84	Disabled-2	0,10	AP-2	Disabled-2	7020	1601	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 .
16139856	0	AP-2	62,66	Gag	21,24	AP-2	Gag	7020	155030(Tax:11676)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2 .
15196531	0	AP-2	44,48	HER2	14,18	AP-2	HER2	7020	2064	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of HER2 and its association with AP-2 in breast_cancer .
24789576	0	AP-2	57,61	HMOX1	18,23	AP-2	HMOX1	7020	3162	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the HMOX1 gene by the transcription factor AP-2 with unique DNA binding site .
17546492	0	AP-2	20,24	LMP1	75,79	AP-2	LMP1	7020	9260	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Role of a consensus AP-2 regulatory sequence within the Epstein-Barr_virus LMP1 promoter in EBNA2 mediated transactivation .
11739124	0	AP-2	81,85	MMP-2	37,42	AP-2	MMP-2	21418(Tax:10090)	17390(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Estradiol upregulates mesangial cell MMP-2 activity via the transcription factor AP-2 .
17022975	0	AP-2	87,91	Numb	19,23	AP-2	Numb	7020	8650	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2 .
8087843	0	AP-2	57,61	Synaptotagmin_I	0,15	AP-2	Synaptotagmin I	7020	6857	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Synaptotagmin_I is a high affinity receptor for clathrin AP-2 : implications for membrane recycling .
12072434	0	AP-2	21,25	UBC9	69,73	AP-2	UBC9	7020	7329	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo .
8922411	0	AP-2	21,25	apolipoprotein_E	42,58	AP-2	apolipoprotein E	7020	348	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transcription factor AP-2 regulates human apolipoprotein_E gene expression in astrocytoma cells .
23690606	0	AP-2	50,54	arrestin	7,15	AP-2	arrestin	21418(Tax:10090)	20215(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina .
12900408	0	AP-2	74,78	beta2	32,37	AP-2	beta2	7020	10242	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal_growth_factor_receptor trafficking .
16723738	0	AP-2	131,135	beta2-adaptin	102,115	AP-2	beta2-adaptin	21418(Tax:10090)	163	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex subunit|amod|END_ENTITY	Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex .
23975899	0	AP-2	29,33	brassinosteroid_insensitive1	58,86	AP-2	brassinosteroid insensitive1	829845(Tax:3702)	830095(Tax:3702)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|endocytosis endocytosis|nmod|END_ENTITY	The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid_insensitive1 in Arabidopsis .
9478951	0	AP-2	107,111	cartilage-derived_retinoic_acid-sensitive_protein	24,73	AP-2	cartilage-derived retinoic acid-sensitive protein	21418(Tax:10090)	12587(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the mouse cartilage-derived_retinoic_acid-sensitive_protein gene by the transcription factor AP-2 .
7822287	0	AP-2	112,116	epidermal_growth_factor_receptor	34,66	AP-2	epidermal growth factor receptor	7020	1956	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Stoichiometric interaction of the epidermal_growth_factor_receptor with the clathrin-associated protein complex AP-2 .
8557749	0	AP-2	98,102	eps15	30,35	AP-2	eps15	7020	2060	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2 .
7559606	0	AP-2	21,25	insulin-like_growth_factor_binding_protein-5	42,86	AP-2	insulin-like growth factor binding protein-5	7020	3488	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transcription factor AP-2 regulates human insulin-like_growth_factor_binding_protein-5 gene expression .
11454741	0	AP-2	30,34	stoned_B	6,14	AP-2	stoned B	7020	4379834(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human stoned_B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating .
14636996	0	AP-2_epsilon	42,54	AP-2	78,82	AP-2 epsilon	AP-2	339488	7020	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Molecular cloning and characterization of AP-2_epsilon , a fifth member of the AP-2 family .
15305293	0	AP-2_epsilon	76,88	AP-2	49,53	AP-2 epsilon	AP-2	332937(Tax:10090)	21418(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Identification and embryonic expression of a new AP-2 transcription factor , AP-2_epsilon .
11596105	0	AP-2_transcription_factor	14,39	c-kit	75,80	AP-2 transcription factor	c-kit	7020	3815	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Expression of AP-2_transcription_factor and of its downstream target genes c-kit , E-cadherin and p21 in human cutaneous_melanoma .
22182699	0	AP-2a	45,50	IFN-y	14,19	AP-2a	IFN-y	7020	3458	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of IFN-y receptor 1 expression by AP-2a influences IFN-y sensitivity of cancer cells .
25896037	0	AP-2a	5,10	IRF6	0,4	AP-2a	IRF6	7020	3664	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	IRF6 AP-2a binding site promoter polymorphism is associated with oral clefts in Latvia .
23224762	0	AP-2a	98,103	Raf1	32,36	AP-2a	Raf1	7020	5894	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Hepatitis_B_virus regulation of Raf1 promoter activity through activation of transcription factor AP-2a .
21979958	0	AP-2a	118,123	a7_nicotinic_acetylcholine_receptor	34,69	AP-2a	a7 nicotinic acetylcholine receptor	7020	1139	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|gene gene|amod|END_ENTITY	Transcriptional repression of the a7_nicotinic_acetylcholine_receptor subunit gene -LRB- CHRNA7 -RRB- by activating protein-2a -LRB- AP-2a -RRB- .
20805990	0	AP-2alpha	14,23	CREB	0,4	AP-2alpha	CREB	7020	1385	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma .
17097614	0	AP-2alpha	46,55	Glutathione_peroxidase-1	0,24	AP-2alpha	Glutathione peroxidase-1	7020	2876	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Glutathione_peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes .
12845703	0	AP-2alpha	86,95	Klf4	46,50	AP-2alpha	Klf4	21418(Tax:10090)	16600(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Dynamic expression of Kr __ ppel-like_factor_4 -LRB- Klf4 -RRB- , a target of transcription factor AP-2alpha during murine mid-embryogenesis .
17621592	0	AP-2alpha	21,30	MUC4	56,60	AP-2alpha	MUC4	7020	4585	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic_cancer cell proliferation .
11438643	0	AP-2alpha	21,30	caspase_6	60,69	AP-2alpha	caspase 6	21418(Tax:10090)	12368(Tax:10090)	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Transcription factor AP-2alpha is preferentially cleaved by caspase_6 and degraded by proteasome during tumor_necrosis_factor_alpha-induced apoptosis in breast_cancer cells .
12062896	0	AP-2alpha	0,9	corticotropin-releasing_hormone	26,57	AP-2alpha	corticotropin-releasing hormone	7020	1392	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	AP-2alpha modulates human corticotropin-releasing_hormone gene expression in the placenta by direct protein-protein interaction .
16636674	0	AP-2alpha	0,9	p53	55,58	AP-2alpha	p53	7020	7157	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast_carcinoma cells .
16698963	0	AP-2beta	42,50	GAS41	0,5	AP-2beta	GAS41	7021	8089	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation .
11522791	0	AP-2delta	73,82	AP-2	46,50	AP-2delta	AP-2	226896(Tax:10090)	21418(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Cloning and characterization of a novel mouse AP-2 transcription factor , AP-2delta , with unique DNA binding and transactivation properties .
19476490	0	AP-2epsilon	59,70	Sox9	44,48	AP-2epsilon	Sox9	339488	6662	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The cartilage-specific transcription factor Sox9 regulates AP-2epsilon expression in chondrocytes .
16684505	0	AP-2epsilon	87,98	integrin_alpha10	14,30	AP-2epsilon	integrin alpha10	339488	8515	Gene	Gene	Regulation|amod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of integrin_alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1 .
14565844	0	AP-2gamma	26,35	Activator_protein-2gamma	0,24	AP-2gamma	Activator protein-2gamma	7022	7022	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Activator_protein-2gamma -LRB- AP-2gamma -RRB- expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5 ' - untranslated region .
12733991	0	AP-2gamma	56,65	activator_protein-2gamma	30,54	AP-2gamma	activator protein-2gamma	7022	7022	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the human activator_protein-2gamma -LRB- AP-2gamma -RRB- gene : control of expression by Sp1/Sp3 in breast_tumour cells .
9765260	0	AP-2gamma	21,30	adenosine_deaminase	48,67	AP-2gamma	adenosine deaminase	21420(Tax:10090)	11486(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transcription factor AP-2gamma regulates murine adenosine_deaminase gene expression during placental development .
24098050	0	AP-3	32,36	AGB1	77,81	AP-3	AGB1	824601(Tax:3702)	829597(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Arabidopsis adaptor protein AP-3 interacts with the G-protein b subunit AGB1 and is involved in abscisic_acid regulation of germination and post-germination development .
14657250	0	AP-3	41,45	ZnT3	21,25	AP-3	ZnT3	11774(Tax:10090)	22784(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation .
7800474	0	AP-4	21,25	Tax	106,109	AP-4	Tax	7023	6900	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	Transcription factor AP-4 participates in activation of bovine_leukemia_virus long terminal repeat by p34 Tax .
18208837	0	AP-endonuclease	24,39	p53	88,91	AP-endonuclease	p53	328	7157	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of the human AP-endonuclease -LRB- APE1/Ref -1 -RRB- expression by the tumor suppressor p53 in response to DNA damage .
8954125	0	AP1	51,54	B-ATF	28,33	AP1	B-ATF	3726	10538	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	IFP_35 forms complexes with B-ATF , a member of the AP1 family of transcription factors .
9512001	0	AP1	46,49	CA1	77,80	AP1	CA1	3725	759	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Prolongation by bifemelane of potentiation of AP1 DNA binding in hippocampal CA1 subfield of gerbils with transient forebrain_ischemia .
10618645	0	AP1	21,24	Calphostin_C	0,12	AP1	Calphostin C	3725	10367	Gene	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Calphostin_C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein_kinase_C-alpha inhibition : possible role for c-jun N-terminal kinase .
23814048	0	AP1	99,102	ER	68,70	AP1	ER	3725	2099	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
7601253	0	AP1	29,32	Erythropoietin	0,14	AP1	Erythropoietin	2353	2056	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Erythropoietin activation of AP1 -LRB- Fos/Jun -RRB- .
16368201	0	AP1	44,47	ZNF445	87,93	AP1	ZNF445	3725	353274	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445 .
15790882	0	AP1	23,26	involucrin	3,13	AP1	involucrin	3726	3713	Gene	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	An involucrin promoter AP1 transcription factor binding site is required for expression of involucrin in the corneal epithelium in vivo .
10397769	0	AP180	33,38	UNC-11	0,6	AP180	UNC-11	9892	171952(Tax:6239)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	UNC-11 , a Caenorhabditis_elegans AP180 homologue , regulates the size and protein composition of synaptic vesicles .
17682829	0	AP2	21,24	DORNROSCHEN-LIKE	0,16	AP2	DORNROSCHEN-LIKE	829845(Tax:3702)	839073;837856	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	DORNROSCHEN-LIKE , an AP2 gene , is necessary for stamen emergence in Arabidopsis .
16339853	0	AP2	31,34	LEAFY_PETIOLE	57,70	AP2	LEAFY PETIOLE	829845(Tax:3702)	831238(Tax:3702)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	A new role for the Arabidopsis AP2 transcription factor , LEAFY_PETIOLE , in gibberellin-induced germination is revealed by the misexpression of a homologous gene , SOB2/DRN-LIKE .
11502761	0	AP2	4,7	synaptotagmin_1	24,39	AP2	synaptotagmin 1	79451(Tax:10116)	25716(Tax:10116)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The AP2 binding site of synaptotagmin_1 is not an internalization signal but a regulator of endocytosis .
24708097	0	AP2S1	60,65	adaptor_protein_2_sigma_subunit	27,58	AP2S1	adaptor protein 2 sigma subunit	1175	1175	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of the adaptor_protein_2_sigma_subunit -LRB- AP2S1 -RRB- gene : search for autosomal dominant hypocalcemia type 3 -LRB- ADH3 -RRB- .
16794002	0	AP2_gamma	28,37	placental_lactogen_II	47,68	AP2 gamma	placental lactogen II	362280(Tax:10116)	24283(Tax:10116)	Gene	Gene	identification|nmod|START_ENTITY END_ENTITY|nsubj|identification	Proteomic identification of AP2_gamma as a rat placental_lactogen_II trophoblast cell-specific enhancer binding protein .
23949224	0	AP4	0,3	p16	27,30	AP4	p16	83383(Tax:10090)	12578(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation .
12646615	0	AP50	43,47	CD22	22,26	AP50	CD22	1173	933	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	The B cell coreceptor CD22 associates with AP50 , a clathrin-coated pit adapter protein , via tyrosine-dependent interaction .
9256472	0	AP50	27,31	CTLA-4	15,21	AP50	CTLA-4	1173	12477(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CTLA-4 with AP50 , a clathrin-coated pit adaptor protein .
19608358	0	APA	44,47	aminopeptidase_A	26,42	APA	aminopeptidase A	64017(Tax:10116)	64017(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant aminopeptidase_A -LRB- APA -RRB- on hypertension in pregnant spontaneously hypertensive rats -LRB- SHRs -RRB- .
24249161	0	APAF-1	72,78	caspase-9	79,88	APAF-1	caspase-9	317	842	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1 / caspase-9 apoptotic pathway in colorectal_cancer cells .
25565868	0	APAF-1	24,30	cathepsin_B	59,70	APAF-1	cathepsin B	317	1508	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Decreased expression of APAF-1 and increased expression of cathepsin_B in invasive pituitary_adenoma .
11559530	0	APAF-1	0,6	p53	38,41	APAF-1	p53	317	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis .
16331630	0	APAF-1	13,19	p53	82,85	APAF-1	p53	317	7157	Gene	Gene	Silencing|nmod|START_ENTITY Silencing|nmod|case case|nmod|mutation mutation|compound|END_ENTITY	Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation .
24992592	0	APAF1	27,32	miR-23a	19,26	APAF1	miR-23a	317	407010	Gene	Gene	regulation|compound|START_ENTITY regulation|amod|END_ENTITY	The involvement of miR-23a / APAF1 regulation axis in colorectal_cancer .
11591730	0	APAF1	0,5	p53	42,45	APAF1	p53	317	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death .
15389287	0	APAF1	64,69	p53	98,101	APAF1	p53	317	7157	Gene	Gene	locus|compound|START_ENTITY located|nmod|locus gene|acl|located regulated|nsubjpass|gene regulated|nmod|END_ENTITY	A highly conserved proapoptotic gene , IKIP , located next to the APAF1 gene locus , is regulated by p53 .
10574372	0	APBA3	46,51	X11L2	34,39	APBA3	X11L2	9546	9546	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the human X11L2 gene -LRB- APBA3 -RRB- , a third member of the X11 protein family interacting with Alzheimer 's beta-amyloid_precursor_protein .
12727304	0	APBB1	63,68	FE65	75,79	APBB1	FE65	322	322	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A risk for early-onset Alzheimer 's _ disease associated with the APBB1 gene -LRB- FE65 -RRB- intron 13 polymorphism .
11956815	0	APC	44,47	Beta-catenin	0,12	APC	Beta-catenin	324	1499	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis .
18854359	0	APC	55,58	Beta-catenin	0,12	APC	Beta-catenin	324	1499	Gene	Gene	domain|nmod|START_ENTITY mediated|nmod|domain degradation|acl|mediated degradation|amod|END_ENTITY	Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal , desmoid_and_duodenal_tumours .
18854359	0	APC	97,100	Beta-catenin	0,12	APC	Beta-catenin	324	1499	Gene	Gene	mutations|compound|START_ENTITY selection|nmod|mutations model|nmod|selection provides|dobj|model provides|nsubj|degradation degradation|amod|END_ENTITY	Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal , desmoid_and_duodenal_tumours .
10526234	0	APC	100,103	E-APC	39,44	APC	E-APC	44642(Tax:7227)	42871(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of E-APC , a novel Drosophila homologue of the tumour suppressor APC .
7604852	0	APC	68,71	adenomatous_polyposis_coli	35,61	APC	adenomatous polyposis coli	324	324	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	High resolution genetic map of the adenomatous_polyposis_coli gene -LRB- APC -RRB- region .
24496450	0	APC	80,83	b-catenin	67,76	APC	b-catenin	324	1499	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the phosphorylation and nuclear import and export of b-catenin by APC and its cancer-related truncated form .
10980707	0	APC	33,36	beta-catenin	47,59	APC	beta-catenin	324	1499	Gene	Gene	shuttling|nmod|START_ENTITY regulates|nsubj|shuttling regulates|dobj|localization localization|amod|END_ENTITY	Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover .
11062151	0	APC	43,46	beta-catenin	14,26	APC	beta-catenin	324	1499	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues .
11396184	0	APC	97,100	beta-catenin	52,64	APC	beta-catenin	324	1499	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene related|nmod|mutations related|nsubjpass|expression expression|nmod|END_ENTITY	Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal_cancer .
12628243	0	APC	148,151	beta-catenin	39,51	APC	beta-catenin	324	1499	Gene	Gene	protein|compound|START_ENTITY Differences|nmod|protein Differences|nmod|interaction interaction|nmod|END_ENTITY	Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino_acid residue repeats of the APC protein .
14654913	0	APC	100,103	beta-catenin	24,36	APC	beta-catenin	324	1499	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene accumulation|nmod|region accumulation|nmod|END_ENTITY	Nuclear accumulation of beta-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial_adenomatous_polyposis patient .
17968317	0	APC	6,9	beta-catenin	21,33	APC	beta-catenin	44642(Tax:7227)	31151(Tax:7227)	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model .
19966865	0	APC	104,107	beta-catenin	62,74	APC	beta-catenin	324	1499	Gene	Gene	mutations|compound|START_ENTITY degradation|nmod|mutations degradation|amod|END_ENTITY	Contribution of the 15 amino_acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal_tumours from FAP patients .
19966865	0	APC	55,58	beta-catenin	62,74	APC	beta-catenin	324	1499	Gene	Gene	repeats|nmod|START_ENTITY amino_acid|dobj|repeats amino_acid|nmod|degradation degradation|amod|END_ENTITY	Contribution of the 15 amino_acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal_tumours from FAP patients .
8259518	0	APC	19,22	beta-catenin	41,53	APC	beta-catenin	324	1499	Gene	Gene	product|compound|START_ENTITY Association|nmod|product Association|nmod|END_ENTITY	Association of the APC gene product with beta-catenin .
8670282	0	APC	29,32	beta-catenin	50,62	APC	beta-catenin	11789(Tax:10090)	12387(Tax:10090)	Gene	Gene	START_ENTITY|dobj|colocalizes colocalizes|nmod|cells cells|amod|END_ENTITY	The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells .
9199178	0	APC	43,46	beta-catenin	12,24	APC	beta-catenin	479139(Tax:9615)	477032(Tax:9615)	Gene	Gene	protein|compound|START_ENTITY interactions|nmod|protein interactions|amod|END_ENTITY	Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis .
9268294	0	APC	68,71	p34	104,107	APC	p34	324	902	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of the tumor suppressor adenomatous_polyposis_coli -LRB- APC -RRB- by the cyclin-dependent kinase p34 .
10230407	0	APC11	19,24	ROC1	0,4	APC11	ROC1	51529	9978	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	ROC1 , a homolog of APC11 , represents a family of cullin partners with an associated ubiquitin ligase activity .
3759147	0	APCS	76,80	serum_amyloid_P_component	44,69	APCS	serum amyloid P component	325	325	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human C-reactive_protein gene -LRB- CRP -RRB- and serum_amyloid_P_component gene -LRB- APCS -RRB- are located on the proximal long arm of chromosome 1 .
22241832	0	APCs	30,34	CD40	12,16	APCs	CD40	20219(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation .
19995901	0	APCs	29,33	CD8	53,56	APCs	CD8	325	925	Gene	Gene	antigen|nmod|START_ENTITY inactivates|nsubj|antigen inactivates|dobj|cells cells|compound|END_ENTITY	Targeting antigen to diverse APCs inactivates memory CD8 + T cells without eliciting tissue-destructive effector function .
22174448	0	APCs	77,81	CD8	87,90	APCs	CD8	325	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Antigen-specific transfer of functional programmed_death_ligand_1 from human APCs onto CD8 + T cells via trogocytosis .
22019586	0	APCs	32,36	IL-21	13,18	APCs	IL-21	20219(Tax:10090)	60505(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice .
20194724	0	APCs	46,50	IL-23	26,31	APCs	IL-23	325	51561	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Triptolide inhibits IL-12 / IL-23 expression in APCs via CCAAT/enhancer-binding _ protein_alpha .
19812202	0	APCs	71,75	LL-37	27,32	APCs	LL-37	325	820	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs .
21268011	0	APCs	32,36	PD-L1	0,5	APCs	PD-L1	325	29126	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	PD-L1 expression on tolerogenic APCs is controlled by STAT-3 .
26377038	0	APE1	49,53	AP_endonuclease_1	30,47	APE1	AP endonuclease 1	328	328	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Efficient inhibition of human AP_endonuclease_1 -LRB- APE1 -RRB- via substrate masking by abasic site-binding macrocyclic ligands .
2689224	1	APE1	68,72	LAP4	74,78	APE1	LAP4	853758(Tax:4932)	853758(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and regulation of the APE1 -LRB- LAP4 -RRB- structural gene .
22306120	0	APE1	48,52	OGG1	42,46	APE1	OGG1	328	4968	Gene	Gene	XRCC1|appos|START_ENTITY XRCC1|compound|END_ENTITY	Genetic polymorphisms in DNA repair genes OGG1 , APE1 , XRCC1 , and XPD and the risk of age-related cataract .
24356447	0	APE1	60,64	SIRT1	0,5	APE1	SIRT1	328	23411	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements .
23669291	0	APE1	22,26	XPD	17,20	APE1	XPD	328	2068	Gene	Gene	XRCC1|appos|START_ENTITY XRCC1|compound|END_ENTITY	The influence of XPD , APE1 , XRCC1 , and NBS1 polymorphic variants on DNA repair in cells exposed to X-rays .
15210853	0	APE1	31,35	apurinic_endonuclease_1	6,29	APE1	apurinic endonuclease 1	328	328	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Human apurinic_endonuclease_1 -LRB- APE1 -RRB- expression and prognostic significance in osteosarcoma : enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition .
12519758	1	APE1	73,77	hNTH1	81,86	APE1	hNTH1	328	4913	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of human APE1 on hNTH1 activity .
11376153	0	APE2	107,111	proliferating_cell_nuclear_antigen	138,172	APE2	proliferating cell nuclear antigen	27301	5111	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria , while nuclear APE2 is partly associated with proliferating_cell_nuclear_antigen .
22450362	0	APECED	60,66	AIRE	101,105	APECED	AIRE	326	326	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of two novel mutations in the first Sicilian APECED patient with no R203X mutation in AIRE gene and review of Italian APECED genotypes .
21750030	0	APETALA1	61,69	LATE_MERISTEM_IDENTITY2	0,23	APETALA1	LATE MERISTEM IDENTITY2	843244(Tax:3702)	825297(Tax:3702)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	LATE_MERISTEM_IDENTITY2 acts together with LEAFY to activate APETALA1 .
8624440	0	APETALA2	122,130	TINY	85,89	APETALA2	TINY	829845(Tax:3702)	832650(Tax:3702)	Gene	Gene	related|nmod|START_ENTITY gene|acl|related END_ENTITY|appos|gene	A Dissociation insertion causes a semidominant mutation that increases expression of TINY , an Arabidopsis gene related to APETALA2 .
11096087	0	APG14	14,19	Gln3p	69,74	APG14	Gln3p	852425(Tax:4932)	856763(Tax:4932)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of APG14 expression by the GATA-type transcription factor Gln3p .
16995899	0	APG6	54,58	Hsp101	36,42	APG6	Hsp101	831398(Tax:3702)	843771(Tax:3702)	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	An Arabidopsis chloroplast-targeted Hsp101 homologue , APG6 , has an essential role in chloroplast development as well as heat-stress response .
2163618	0	APH	46,49	aminoglycoside_phosphotransferase	11,44	APH	aminoglycoside phosphotransferase	4246774(Tax:562)	4246774(Tax:562)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of aminoglycoside_phosphotransferase -LRB- APH -RRB- gene from antibiotic-producing strain of Bacillus circulans into a high-expression vector , pKK223-3 .
17325205	0	APH-1	20,25	Rer1p	0,5	APH-1	Rer1p	51107	11079	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway .
15189355	0	APH-1	30,35	nicastrin	9,18	APH-1	nicastrin	51107	23385	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin : identification of nicastrin mutants that selectively interact with APH-1 .
22345097	0	API-1	24,29	TRAIL	77,82	API-1	TRAIL	329	8743	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition .
22345097	0	API-1	24,29	c-FLIP	38,44	API-1	c-FLIP	329	8837	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition .
10525157	0	APJ	50,53	Apelin	0,6	APJ	Apelin	83518(Tax:10116)	58812(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Apelin , the natural ligand of the orphan receptor APJ , is abundantly secreted in the colostrum .
11090199	0	APJ	70,73	Apelin	0,6	APJ	Apelin	187	8862	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Apelin , the natural ligand of the orphan seven-transmembrane receptor APJ , inhibits human_immunodeficiency_virus_type_1 entry .
12215493	0	APJ	59,62	Apelin	0,6	APJ	Apelin	83518(Tax:10116)	58812(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Apelin , the novel endogenous ligand of the orphan receptor APJ , regulates cardiac contractility .
16750822	0	APJ	67,70	Apelin	0,6	APJ	Apelin	23796(Tax:10090)	30878(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY ligand|nmod|receptor END_ENTITY|appos|ligand	Apelin , the ligand for the endothelial G-protein-coupled receptor , APJ , is a potent angiogenic factor required for normal vascular development of the frog embryo .
22834038	0	APJ	35,38	Apelin	27,33	APJ	Apelin	187	8862	Gene	Gene	Receptor|appos|START_ENTITY Receptor|compound|END_ENTITY	Functional Agonists of the Apelin -LRB- APJ -RRB- Receptor The recently discovered apelin receptor -LRB- APJ , AGTRL-1 , APLNR -RRB- system has emerged as a critical mediator of cardiovascular homeostasis involved in the pathogenesis of hypertension , heart_failure , atherosclerosis and other cardiovascular_diseases .
23658961	0	APJ	38,41	Apelin	30,36	APJ	Apelin	187	8862	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Functional antagonists of the Apelin -LRB- APJ -RRB- receptor The recently discovered apelin receptor -LRB- APJ , AGTRL-1 , APLNR -RRB- system has emerged as a critical mediator of cardiovascular homeostasis and is involved in the pathogenesis of hypertension , heart_failure , atherosclerosis , and other cardiovascular_diseases .
21412239	0	APJ	14,17	angiotensin_II_type_1_receptor	33,63	APJ	angiotensin II type 1 receptor	187	185	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Non-activated APJ suppresses the angiotensin_II_type_1_receptor , whereas apelin-activated APJ acts conversely .
10617103	0	APJ	47,50	apelin	20,26	APJ	apelin	83518(Tax:10116)	58812(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY ligand|nmod|receptor Characterization|appos|ligand Characterization|nmod|END_ENTITY	Characterization of apelin , the ligand for the APJ receptor .
12494874	0	APJ	68,71	apelin	29,35	APJ	apelin	187	8862	Gene	Gene	ligand|nmod|START_ENTITY study|appos|ligand study|nmod|END_ENTITY	Immunohistochemical study of apelin , the natural ligand of receptor APJ , in a case of AIDS-related cachexia .
12914775	0	APJ	82,85	apelin	34,40	APJ	apelin	187	8862	Gene	Gene	ligand|nmod|START_ENTITY novel|acl|ligand levels|appos|novel levels|nmod|END_ENTITY	Circulating and cardiac levels of apelin , the novel ligand of the orphan receptor APJ , in patients with heart_failure .
15664671	0	APJ	56,59	apelin	39,45	APJ	apelin	187	58812(Tax:10116)	Gene	Gene	localisation|appos|START_ENTITY localisation|nmod|receptor receptor|compound|END_ENTITY	Immunocytochemical localisation of the apelin receptor , APJ , to human cardiomyocytes , vascular smooth muscle and endothelial cells .
25150624	0	APJ	101,104	apelin	77,83	APJ	apelin	187	8862	Gene	Gene	START_ENTITY|nsubj|evidences evidences|nmod|role role|nmod|regulation regulation|nmod|END_ENTITY	Molecular and physiological evidences for the role in appetite regulation of apelin and its receptor APJ in Ya-fish -LRB- Schizothorax prenanti -RRB- .
17826642	0	APJ_receptor	24,36	apelin	70,76	APJ receptor	apelin	187	8862	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	The 212A variant of the APJ_receptor gene for the endogenous inotrope apelin is associated with slower heart_failure progression in idiopathic_dilated_cardiomyopathy .
23449221	0	APLF	48,52	PARP3	4,9	APLF	PARP3	200558	10039	Gene	Gene	break|compound|START_ENTITY phosphorylation|nmod|break phosphorylation|amod|END_ENTITY	The PARP3 - and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair .
25683482	0	APLP1	0,5	APP	32,35	APLP1	APP	333	351	Gene	Gene	START_ENTITY|appos|members members|nmod|family family|compound|END_ENTITY	APLP1 and APLP2 , members of the APP family of proteins , behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression .
17533371	0	APLP1	36,41	p53	53,56	APLP1	p53	333	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress .
24898256	0	APLP2	52,57	APP-like_protein_2	32,50	APLP2	APP-like protein 2	11804(Tax:10090)	11804(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Amyloid_precursor_protein -LRB- APP -RRB- / APP-like_protein_2 -LRB- APLP2 -RRB- expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan_sulfate .
24898256	0	APLP2	52,57	Amyloid_precursor_protein	0,25	APLP2	Amyloid precursor protein	11804(Tax:10090)	11820(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Amyloid_precursor_protein -LRB- APP -RRB- / APP-like_protein_2 -LRB- APLP2 -RRB- expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan_sulfate .
25966186	0	APM-1	59,64	adiponectin	41,52	APM-1	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between polymorphisms in the adiponectin gene -LRB- APM-1 -RRB- and atherosclerotic_cerebral_infarction in a Hainan Chinese Han population .
14749263	0	APM1	84,88	adiponectin	71,82	APM1	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms in the proximal promoter region of the adiponectin -LRB- APM1 -RRB- gene are associated with type 2 diabetes in Swedish caucasians .
19263799	0	APM1	82,86	adiponectin	69,80	APM1	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a regulatory single nucleotide polymorphism in the adiponectin -LRB- APM1 -RRB- gene associated with type 2 diabetes in Han nationality .
21254618	0	APM1	59,63	adiponectin	46,57	APM1	adiponectin	9370	9370	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Single nucleotide polymorphism of +276 _ g _ > _ t adiponectin -LRB- APM1 -RRB- gene in donors of Kharkiv population -RSB- .
9257688	0	APN	38,41	CD13	43,47	APN	CD13	290	290	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	The activation-dependent induction of APN - -LRB- CD13 -RRB- in T-cells is controlled at different levels of gene expression .
21550066	0	APN	42,45	aminopeptidase_N	24,40	APN	aminopeptidase N	290	290	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of alanine aminopeptidase_N -LRB- APN -RRB- in bile in the diagnosis of acute cellular rejection after liver transplantation .
10910654	0	APO-1	121,126	CD95	132,136	APO-1	CD95	355	355	Gene	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	-LSB- Apoptosis and hepatic cell proliferation in autoimmune_hepatitis and chronic_viral_hepatitis_C in children : analysis of APO-1 / Fas -LRB- CD95 -RRB- , bcl-2 and Ki67 expression -RSB- .
7528670	0	APO-1	4,9	CD95	15,19	APO-1	CD95	14102(Tax:10090)	14102(Tax:10090)	Gene	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	The APO-1 / Fas -LRB- CD95 -RRB- receptor is expressed in homozygous MRL/lpr mice .
7539660	0	APO-1	27,32	CD95	38,42	APO-1	CD95	355	355	Gene	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	Functional consequences of APO-1 / Fas -LRB- CD95 -RRB- antigen expression by normal and neoplastic hematopoietic cells .
7575348	0	APO-1	24,29	CD95	34,38	APO-1	CD95	355	355	Gene	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	Molecular mechanisms of APO-1 / Fas -LRB- CD95 -RRB- - mediated apoptosis in tolerance and AIDS .
8688670	0	APO-1	20,25	CD95	14,18	APO-1	CD95	355	355	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Regulation of CD95 -LRB- APO-1 -RRB- expression and the induction of apoptosis in human T cells : changes in old age .
9288794	0	APO-1	10,15	CD95	4,8	APO-1	CD95	355	355	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	The CD95 -LRB- APO-1 / Fas -RRB- system mediates drug-induced apoptosis in neuroblastoma cells .
10479402	0	APO-2_ligand	14,26	trail	27,32	APO-2 ligand	trail	8743	8743	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|compound|END_ENTITY	Regulation of APO-2_ligand / trail expression in NK cells-involvement in NK cell-mediated cytotoxicity .
9754559	0	APO2_ligand	15,26	TRAIL	27,32	APO2 ligand	TRAIL	8743	8743	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of APO2_ligand / TRAIL in activation-induced death of Jurkat and human peripheral blood T cells .
22267484	0	APOA	35,39	FGF19	0,5	APOA	FGF19	335	9965	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	FGF19 signaling cascade suppresses APOA gene expression .
9080263	0	APOA-IV	84,91	APOB	100,104	APOA-IV	APOB	25080(Tax:10116)	54225(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Modulation of apolipoprotein gene expression in fatty_liver of obese rats : enhanced APOA-IV , but no APOB expression by a high sucrose diet .
12136239	0	APOA2	61,66	apolipoprotein_AII	35,53	APOA2	apolipoprotein AII	336	336	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence polymorphism at the human apolipoprotein_AII gene -LRB- APOA2 -RRB- : unexpected deficit of variation in an African-American sample .
3095836	0	APOA4	77,82	apolipoprotein_A4	53,70	APOA4	apolipoprotein A4	337	337	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure , evolution , and polymorphisms of the human apolipoprotein_A4 gene -LRB- APOA4 -RRB- .
12937897	0	APOA5	70,75	apolipoprotein_A5	51,68	APOA5	apolipoprotein A5	116519	116519	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The single nucleotide polymorphism -1131 T > C in the apolipoprotein_A5 -LRB- APOA5 -RRB- gene is associated with elevated triglycerides in patients with hyperlipidemia .
16143024	0	APOA5	40,45	apolipoprotein_A5	21,38	APOA5	apolipoprotein A5	116519	116519	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Polymorphisms in the apolipoprotein_A5 -LRB- APOA5 -RRB- gene and type_III_hyperlipidemia .
16943456	0	APOA5	160,165	apolipoprotein_A5	141,158	APOA5	apolipoprotein A5	116519	116519	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparison of low-fat meal and high-fat meal on postprandial lipemic response in non-obese men according to the -1131 T > C polymorphism of the apolipoprotein_A5 -LRB- APOA5 -RRB- gene -LRB- randomized cross-over design -RRB- .
19056598	0	APOA5	81,86	apolipoprotein_A5	62,79	APOA5	apolipoprotein A5	116519	116519	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between glucokinase_regulatory_protein -LRB- GCKR -RRB- and apolipoprotein_A5 -LRB- APOA5 -RRB- gene polymorphisms and triacylglycerol concentrations in fasting , postprandial , and fenofibrate-treated states .
20688329	0	APOA5	23,28	apolipoprotein_A5	4,21	APOA5	apolipoprotein A5	116519	116519	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The apolipoprotein_A5 -LRB- APOA5 -RRB- gene predisposes Caucasian children to elevated triglycerides and vitamin_E -LRB- Four Provinces Study -RRB- .
21993410	0	APOA5	36,41	apolipoprotein_A5	17,34	APOA5	apolipoprotein A5	116519	116519	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Resequencing the apolipoprotein_A5 -LRB- APOA5 -RRB- gene in patients with various forms of hypertriglyceridemia .
9080263	0	APOB	100,104	APOA-IV	84,91	APOB	APOA-IV	54225(Tax:10116)	25080(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Modulation of apolipoprotein gene expression in fatty_liver of obese rats : enhanced APOA-IV , but no APOB expression by a high sucrose diet .
17588943	0	APOB	22,26	APOB-100	65,73	APOB	APOB-100	338	338	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial_hypobetalipoproteinemia .
25575569	0	APOB	41,45	RAD21	13,18	APOB	RAD21	338	5885	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Mutations in RAD21 Disrupt Regulation of APOB in Patients With Chronic_Intestinal_Pseudo-Obstruction .
17588943	0	APOB-100	65,73	APOB	22,26	APOB-100	APOB	338	338	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial_hypobetalipoproteinemia .
22190030	0	APOB48	40,46	THP-1	81,86	APOB48	THP-1	338	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|monocytes monocytes|compound|END_ENTITY	Triglyceride-rich lipoprotein regulates APOB48 receptor gene expression in human THP-1 monocytes and macrophages .
16427049	0	APOBEC2	14,21	NF-kappaB	56,65	APOBEC2	NF-kappaB	10930	4790	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of APOBEC2 is transcriptionally regulated by NF-kappaB in human hepatocytes .
22948384	0	APOBEC3A	43,51	TET1	16,20	APOBEC3A	TET1	200315	80312	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients .
19074429	0	APOBEC3C	31,39	bet	77,80	APOBEC3C	bet	27350	92737	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet .
16840343	0	APOBEC3G	92,100	CD4	120,123	APOBEC3G	CD4	60489	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells .
17237417	0	APOBEC3G	94,102	CD4	117,120	APOBEC3G	CD4	60489	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4 -LRB- + -RRB- T cells and dendritic cells .
19197360	0	APOBEC3G	15,23	CD4	38,41	APOBEC3G	CD4	60489	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|subtypes subtypes|compound|END_ENTITY	Differences in APOBEC3G expression in CD4 + T helper lymphocyte subtypes modulate HIV-1_infectivity .
26987686	0	APOBEC3G	82,90	CD4	100,103	APOBEC3G	CD4	60489	920	Gene	Gene	START_ENTITY|nmod|T-cell T-cell|compound|END_ENTITY	Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4 -LRB- + -RRB- T-cell activation and dendritic cell maturation .
15609224	0	APOBEC3G	36,44	CEM15	29,34	APOBEC3G	CEM15	60489	60489	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Exhaustive genotyping of the CEM15 -LRB- APOBEC3G -RRB- gene and absence of association with AIDS progression in a French cohort .
17237417	0	APOBEC3G	94,102	HSP70	75,80	APOBEC3G	HSP70	60489	3308	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4 -LRB- + -RRB- T cells and dendritic cells .
11825674	0	APOC1	46,51	apolipoprotein_C-I	26,44	APOC1	apolipoprotein C-I	341	341	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic association of an apolipoprotein_C-I -LRB- APOC1 -RRB- gene polymorphism with late-onset Alzheimer 's _ disease .
16453339	0	APOE	16,20	Apolipoprotein	0,14	APOE	Apolipoprotein	348	348	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Apolipoprotein -LRB- APOE -RRB- gene is associated with progression of age-related_macular_degeneration -LRB- AMD -RRB- .
22221592	0	APOE	23,27	Apolipoprotein_E	0,16	APOE	Apolipoprotein E	348	348	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Apolipoprotein_E gene -LRB- APOE -RRB- genotype in Wilson 's _ disease : impact on clinical presentation .
26574962	0	APOE	49,53	Apolipoprotein_E	31,47	APOE	Apolipoprotein E	348	348	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	-LSB- Prevalence of Variants in the Apolipoprotein_E -LRB- APOE -RRB- Gene in a General Population of Adults from an Urban Area of Medellin -LRB- Antioquia -RRB- -RSB- .
26130946	0	APOE	0,4	C-reactive_Protein	37,55	APOE	C-reactive Protein	348	1401	Gene	Gene	Polymorphism|compound|START_ENTITY Associated|nsubj|Polymorphism Associated|nmod|Levels Levels|compound|END_ENTITY	APOE Polymorphism Is Associated with C-reactive_Protein Levels but Not with White Blood Cell Count : Dong-gu Study and Namwon Study .
16511556	0	APOE	40,44	C-reactive_protein	73,91	APOE	C-reactive protein	348	1401	Gene	Gene	variation|amod|START_ENTITY effects|nmod|variation effects|nmod|END_ENTITY	Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive_protein , LDL-cholesterol , and apoE protein .
20074603	0	APOE	0,4	C-reactive_protein	43,61	APOE	C-reactive protein	348	1401	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	APOE polymorphism and its effect on plasma C-reactive_protein levels in a large general population sample .
24305621	0	APOE	20,24	C-reactive_protein	0,18	APOE	C-reactive protein	348	1401	Gene	Gene	genotype|nsubj|START_ENTITY genotype|advmod|END_ENTITY	C-reactive_protein , APOE genotype and longitudinal_cognitive_change in an older population .
12042130	0	APOE	29,33	LDL_receptor	55,67	APOE	LDL receptor	348	3949	Gene	Gene	START_ENTITY|dobj|genotype genotype|nmod|mutations mutations|compound|END_ENTITY	-LSB- Influence of plasma lipids , APOE genotype and type of LDL_receptor gene mutations on myocardial_infarction in subjects with familial_hypercholesterolemia -RSB- .
27014949	0	APOE	28,32	LDL_receptor	107,119	APOE	LDL receptor	348	3949	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene causes|nsubj|mutation causes|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	The p.Leu167del mutation in APOE gene causes autosomal dominant hypercholesterolemia by down-regulation of LDL_receptor expression in hepatocytes .
21461956	0	APOE	0,4	MTHFR	6,11	APOE	MTHFR	348	4524	Gene	Gene	polymorphisms|advmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	APOE , MTHFR , LDLR and ACE polymorphisms among Angami and Lotha Naga populations of Nagaland , India .
17050040	0	APOE	25,29	Mortalin	0,8	APOE	Mortalin	348	15526(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice .
23919842	0	APOE	20,24	PPARa	34,39	APOE	PPARa	348	5465	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|dep|END_ENTITY	Association between APOE , SCARB1 , PPARa polymorphisms and serum lipids in a population of Lithuanian adults .
11315514	0	APOE	39,43	apolipoprotein_E	21,37	APOE	apolipoprotein E	348	348	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the apolipoprotein_E -LRB- APOE -RRB- gene in gerontopsychiatric patients .
12567264	0	APOE	53,57	apolipoprotein_E	35,51	APOE	apolipoprotein E	348	348	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A pooled case-control study of the apolipoprotein_E -LRB- APOE -RRB- gene in age-related maculopathy .
19058936	0	APOE	36,40	apolipoprotein_E	18,34	APOE	apolipoprotein E	348	348	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A polymorphism of apolipoprotein_E -LRB- APOE -RRB- gene is associated with age at_natural_menopause in Caucasian females .
23554593	0	APOE	30,34	apolipoprotein_E	12,28	APOE	apolipoprotein E	348	348	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of apolipoprotein_E -LRB- APOE -RRB- genotype in early_mild_cognitive_impairment -LRB- E-MCI -RRB- .
26898659	0	APOE	46,50	apolipoprotein_E	28,44	APOE	apolipoprotein E	348	348	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exploring the effect of the apolipoprotein_E -LRB- APOE -RRB- gene on executive function , working memory , and processing speed during the early recovery period following traumatic_brain_injury .
26912074	0	APOE	33,37	apolipoprotein_E	15,31	APOE	apolipoprotein E	348	348	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of apolipoprotein_E -LRB- APOE -RRB- polymorphisms with warfarin maintenance dose in a northern Han Chinese population .
26711810	0	APOH	0,4	FTO	20,23	APOH	FTO	350	79068	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	APOH interacts with FTO to predispose to healthy thinness .
18676959	0	APOH	51,55	apolipoprotein_H	28,44	APOH	apolipoprotein H	350	350	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Comprehensive evaluation of apolipoprotein_H gene -LRB- APOH -RRB- variation identifies novel associations with measures of lipid metabolism in GENOA .
21390319	0	APOM	23,27	Apolipoprotein_M	0,16	APOM	Apolipoprotein M	55937	55937	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Apolipoprotein_M gene -LRB- APOM -RRB- polymorphism modifies metabolic and disease traits in type_2_diabetes .
6657118	0	APO_A	5,10	APO_B	11,16	APO A	APO B	4018	338	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	-LSB- The APO_A / APO_B ratio in the screening of patients at cardiovascular risk -RSB- .
6657118	0	APO_B	11,16	APO_A	5,10	APO B	APO A	338	4018	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	-LSB- The APO_A / APO_B ratio in the screening of patients at cardiovascular risk -RSB- .
26425011	0	APO_E	28,33	apolipoprotein_E	10,26	APO E	apolipoprotein E	348	348	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of apolipoprotein_E -LRB- APO_E -RRB- polymorphism on leptin in Alzheimer 's _ disease .
25683482	0	APP	32,35	APLP1	0,5	APP	APLP1	351	333	Gene	Gene	family|compound|START_ENTITY members|nmod|family END_ENTITY|appos|members	APLP1 and APLP2 , members of the APP family of proteins , behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression .
18573216	0	APP	51,54	APP	9,12	APP	APP	351	351	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin_beta1 .
18573216	0	APP	9,12	APP	51,54	APP	APP	351	351	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin_beta1 .
17468102	0	APP	47,50	Abeta	31,36	APP	Abeta	11820(Tax:10090)	11820(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations .
26053850	0	APP	99,102	Amyloid-b_Precursor_Protein	70,97	APP	Amyloid-b Precursor Protein	351	351	Gene	Gene	Processing|appos|START_ENTITY Processing|compound|END_ENTITY	The Golgi-Localized y-Ear-Containing ARF-Binding -LRB- GGA -RRB- Proteins Alter Amyloid-b_Precursor_Protein -LRB- APP -RRB- Processing through Interaction of Their GAE Domain with the Beta-Site_APP_Cleaving_Enzyme_1 -LRB- BACE1 -RRB- .
26510981	0	APP	143,146	Amyloid_Precursor_Protein	116,141	APP	Amyloid Precursor Protein	351	351	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	The ATP-Binding_Cassette_Transporter-2 -LRB- ABCA2 -RRB- Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid_Precursor_Protein -LRB- APP -RRB- Gene .
7633445	0	APP	76,79	Amyloid_Precursor_Protein	49,74	APP	Amyloid Precursor Protein	351	351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No evidence that common allelic variation in the Amyloid_Precursor_Protein -LRB- APP -RRB- gene confers susceptibility to Alzheimer 's _ disease .
15262269	0	APP	127,130	BDNF	74,78	APP	BDNF	351	12064(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1 .
24068826	0	APP	71,74	BDNF	6,10	APP	BDNF	11820(Tax:10090)	12064(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY cortex|nmod|transgenic_mice ameliorates|nmod|cortex ameliorates|nsubj|treatment treatment|amod|END_ENTITY	Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic_mice .
25710492	0	APP	140,143	BDNF	77,81	APP	BDNF	351	627	Gene	Gene	Role|nmod|START_ENTITY Evidence|nmod|Role Inhibitor|dep|Evidence Inhibitor|appos|Defects Defects|nmod|Trafficking Trafficking|compound|END_ENTITY	A y-Secretase Inhibitor , but Not a y-Secretase Modulator , Induced Defects in BDNF Axonal Trafficking and Signaling : Evidence for a Role for APP .
19849849	0	APP	20,23	CD74	0,4	APP	CD74	351	972	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD74 interacts with APP and suppresses the production of Abeta .
19225519	0	APP	0,3	DR6	10,13	APP	DR6	11820(Tax:10090)	94185(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	APP binds DR6 to trigger axon pruning and neuron_death via distinct caspases .
7695605	0	APP	23,26	IL-1_beta	38,47	APP	IL-1 beta	54226(Tax:10116)	24494(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Enhanced processing of APP induced by IL-1_beta can be reduced by indomethacin and nordihydroguaiaretic_acid .
18095157	0	APP	70,73	IP-10	36,41	APP	IP-10	11820(Tax:10090)	15945(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Decreased fractalkine and increased IP-10 expression in aged brain of APP -LRB- swe -RRB- transgenic_mice .
11245926	0	APP	56,59	LRP	95,98	APP	LRP	351	4035	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP .
20637285	0	APP	23,26	Megalin	0,7	APP	Megalin	351	4036	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Megalin interacts with APP and the intracellular adapter protein FE65 in neurons .
26717550	0	APP	26,29	Nicastrin	0,9	APP	Nicastrin	351	23385	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Nicastrin is required for APP but not Notch processing , while Aph-1 is dispensable for processing of both APP and Notch .
22418058	0	APP	65,68	PS1	74,77	APP	PS1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	The effect of ageing on neurogenesis and oxidative stress in the APP -LRB- swe -RRB- / PS1 -LRB- deltaE9 -RRB- mouse model of Alzheimer 's _ disease .
26600047	0	APP	22,25	SOD1	7,11	APP	SOD1	11820(Tax:10090)	20655(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS .
26581893	0	APP	34,37	TRPC6	0,5	APP	TRPC6	11820(Tax:10090)	22068(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRPC6 specifically interacts with APP to inhibit its cleavage by y-secretase and reduce Ab production .
10051452	0	APP	133,136	amyloid_precursor_protein	106,131	APP	amyloid precursor protein	351	351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Amyloid_precursor_protein metabolism in fibroblasts from individuals with one , two or three copies of the amyloid_precursor_protein -LRB- APP -RRB- gene .
11238715	0	APP	54,57	amyloid_precursor_protein	27,52	APP	amyloid precursor protein	351	351	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	A dinucleotide deletion in amyloid_precursor_protein -LRB- APP -RRB- mRNA associated with sporadic Alzheimer 's _ disease results in efficient secretion of truncated APP isoforms from neuroblastoma cell cultures .
15684649	0	APP	45,48	amyloid_precursor_protein	18,43	APP	amyloid precursor protein	101111593	101111593	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Downregulation of amyloid_precursor_protein -LRB- APP -RRB- expression following post-traumatic cyclosporin-A administration .
16458426	0	APP	77,80	amyloid_precursor_protein	50,75	APP	amyloid precursor protein	351	351	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The repressive effect of green tea ingredients on amyloid_precursor_protein -LRB- APP -RRB- expression in oral_carcinoma cells in vitro and in vivo .
17651731	0	APP	83,86	amyloid_precursor_protein	56,81	APP	amyloid precursor protein	351	351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	AP-2 participates in the transcriptional control of the amyloid_precursor_protein -LRB- APP -RRB- gene in oral_squamous_cell_carcinoma .
1899371	0	APP	54,57	amyloid_precursor_protein	27,52	APP	amyloid precursor protein	351	351	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulatory region of human amyloid_precursor_protein -LRB- APP -RRB- gene promotes neuron-specific gene expression in the CNS of transgenic_mice .
19097908	0	APP	54,57	amyloid_precursor_protein	27,52	APP	amyloid precursor protein	351	351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel polymorphisms of the amyloid_precursor_protein -LRB- APP -RRB- gene in Chinese/Taiwanese patients with Alzheimer 's _ disease .
22245578	0	APP	83,86	amyloid_precursor_protein	56,81	APP	amyloid precursor protein	351	351	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Metal binding dictates conformation and function of the amyloid_precursor_protein -LRB- APP -RRB- E2 domain .
7747597	0	APP	41,44	amyloid_precursor_protein	14,39	APP	amyloid precursor protein	54226(Tax:10116)	54226(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of amyloid_precursor_protein -LRB- APP -RRB- in rat brain and cultured neural cells .
8015372	0	APP	82,85	amyloid_precursor_protein	55,80	APP	amyloid precursor protein	351	351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Protein-DNA interactions in the promoter region of the amyloid_precursor_protein -LRB- APP -RRB- gene in human neocortex .
8611030	0	APP	52,55	amyloid_precursor_protein	25,50	APP	amyloid precursor protein	351	351	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Suppression of Alzheimer amyloid_precursor_protein -LRB- APP -RRB- expression by exogenous APP mRNA .
8738146	0	APP	40,43	amyloid_precursor_protein	13,38	APP	amyloid precursor protein	54226(Tax:10116)	54226(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Two types of amyloid_precursor_protein -LRB- APP -RRB- mRNA in rat glioma cell lines : upregulation via a cyclic_AMP-dependent pathway .
8917100	0	APP	108,111	amyloid_precursor_protein	81,106	APP	amyloid precursor protein	351	351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of cis-acting elements involved in an alternative splicing of the amyloid_precursor_protein -LRB- APP -RRB- gene .
23648941	0	APP	49,52	b-amyloid_precursor_protein	20,47	APP	b-amyloid precursor protein	39399(Tax:7227)	351	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ras signal triggers b-amyloid_precursor_protein -LRB- APP -RRB- expression .
16948926	0	APP	57,60	beta-amyloid_precursor_protein	25,55	APP	beta-amyloid precursor protein	351	351	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	High levels of Alzheimer beta-amyloid_precursor_protein -LRB- APP -RRB- in children with severely autistic_behavior_and_aggression .
19251455	0	APP	48,51	beta-amyloid_precursor_protein	16,46	APP	beta-amyloid precursor protein	351	351	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Two patterns of beta-amyloid_precursor_protein -LRB- APP -RRB- immunoreactivity in cases of blunt head_injury .
1939150	0	APP	62,65	beta-amyloid_precursor_protein	30,60	APP	beta-amyloid precursor protein	351	351	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Conversion of the Alzheimer 's beta-amyloid_precursor_protein -LRB- APP -RRB- Kunitz domain into a potent human neutrophil elastase inhibitor .
7790414	0	APP	56,59	beta-amyloid_precursor_protein	24,54	APP	beta-amyloid precursor protein	54226(Tax:10116)	54226(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Glial expression of the beta-amyloid_precursor_protein -LRB- APP -RRB- in global ischemia .
7898775	0	APP	46,49	beta-amyloid_precursor_protein	14,44	APP	beta-amyloid precursor protein	351	351	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of beta-amyloid_precursor_protein -LRB- APP -RRB- in human dorsal root ganglia .
20458444	0	APP	57,60	miR-20a	0,7	APP	miR-20a	351	406982	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-20a promotes proliferation and invasion by targeting APP in human ovarian_cancer cells .
22539346	0	APP	126,129	phosphatidylinositol_clathrin_assembly_lymphoid-myeloid_leukemia	8,72	APP	phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia	11820(Tax:10090)	233489(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of phosphatidylinositol_clathrin_assembly_lymphoid-myeloid_leukemia -LRB- PICALM -RRB- in intracellular amyloid_precursor_protein -LRB- APP -RRB- processing and amyloid plaque pathogenesis .
20354142	0	APP	86,89	sorting_nexin_6	28,43	APP	sorting nexin 6	351	58533	Gene	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	Proteomic identification of sorting_nexin_6 as a negative regulator of BACE1-mediated APP processing .
18627766	0	APP-BP1	46,53	TRIP12	0,6	APP-BP1	TRIP12	8883	9320	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	TRIP12 functions as an E3 ubiquitin ligase of APP-BP1 .
24898256	0	APP-like_protein_2	32,50	APLP2	52,57	APP-like protein 2	APLP2	11804(Tax:10090)	11804(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Amyloid_precursor_protein -LRB- APP -RRB- / APP-like_protein_2 -LRB- APLP2 -RRB- expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan_sulfate .
24898256	0	APP-like_protein_2	32,50	Amyloid_precursor_protein	0,25	APP-like protein 2	Amyloid precursor protein	11804(Tax:10090)	11820(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Amyloid_precursor_protein -LRB- APP -RRB- / APP-like_protein_2 -LRB- APLP2 -RRB- expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan_sulfate .
19661063	0	APPL	48,52	adiponectin	23,34	APPL	adiponectin	26060	9370	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells .
20484574	0	APPL1	19,24	Cdo	0,3	APPL1	Cdo	26060	1036	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cdo interacts with APPL1 and activates Akt in myoblast differentiation .
17030088	0	APPL1	0,5	FSHR	44,48	APPL1	FSHR	26060	2492	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	APPL1 , APPL2 , Akt2 and FOXO1a interact with FSHR in a potential signaling complex .
25780039	0	APPL1	11,16	TBK1	37,41	APPL1	TBK1	26060	29110	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	A Role for APPL1 in TLR3/4-Dependent TBK1 and IKK Activation in Macrophages .
17000777	0	APPL1	0,5	TrkA	22,26	APPL1	TrkA	290537(Tax:10116)	59109(Tax:10116)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	APPL1 associates with TrkA and GIPC1 and is required for nerve_growth_factor-mediated signal transduction .
18854421	0	APPL1	0,5	adiponectin	15,26	APPL1	adiponectin	26060	9370	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	APPL1 : role in adiponectin signaling and beyond .
20978232	0	APPL1	0,5	p38_MAPK	38,46	APPL1	p38 MAPK	72993(Tax:10090)	26416(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	APPL1 mediates adiponectin-stimulated p38_MAPK activation by scaffolding the TAK1-MKK3-p38_MAPK pathway .
21723284	0	APR3	16,20	NELL-1	0,6	APR3	NELL-1	51374	4745	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation .
8272872	0	APRF	36,40	gp130	106,111	APRF	gp130	6774	3572	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 .
18423122	0	APRIL	15,20	APRIL	95,100	APRIL	APRIL	8741	8741	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|expression expression|amod|END_ENTITY	-LSB- Expression of APRIL in colorectal_carcinoma tissues and effects of chemotherapeutic agents on APRIL expression in colorectal_carcinoma SW480 cells -RSB- .
18423122	0	APRIL	95,100	APRIL	15,20	APRIL	APRIL	8741	8741	Gene	Gene	expression|amod|START_ENTITY Expression|nmod|expression Expression|nmod|END_ENTITY	-LSB- Expression of APRIL in colorectal_carcinoma tissues and effects of chemotherapeutic agents on APRIL expression in colorectal_carcinoma SW480 cells -RSB- .
23337484	0	APRIL	57,62	A_Proliferation-Inducing_Ligand	24,55	APRIL	A Proliferation-Inducing Ligand	8741	8741	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of A_Proliferation-Inducing_Ligand -LRB- APRIL -RRB- are elevated in sepsis and predict mortality in critically ill patients .
21595749	0	APRIL	33,38	A_proliferation-inducing_ligand	0,31	APRIL	A proliferation-inducing ligand	8741	8741	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	A_proliferation-inducing_ligand -LRB- APRIL -RRB- serum levels predict time to first treatment in patients affected by B-cell_chronic_lymphocytic_leukemia .
23071284	0	APRIL	0,5	BCMA	17,21	APRIL	BCMA	8741	608	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells .
24376672	0	APRIL	6,11	BCMA	20,24	APRIL	BCMA	8741	608	Gene	Gene	TACI|appos|START_ENTITY TACI|appos|END_ENTITY	BAFF , APRIL , TWEAK , BCMA , TACI and Fn14 proteins are related to human glioma_tumor grade : immunohistochemistry and public microarray data meta-analysis .
17178712	0	APRIL	60,65	CD83	87,91	APRIL	CD83	10541	9308	Gene	Gene	ligand|dobj|START_ENTITY ligand|nmod|expression expression|compound|END_ENTITY	Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression .
19130553	0	APRIL	34,39	CD83	69,73	APRIL	CD83	10541	9308	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression .
25057039	0	APRIL	0,5	IL-17	37,42	APRIL	IL-17	8741	3605	Gene	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	APRIL levels strongly correlate with IL-17 in systemic_lupus_erythematosus .
24504026	0	APRIL	89,94	IL-6	0,4	APRIL	IL-6	8741	3569	Gene	Gene	supports|nmod|START_ENTITY supports|nsubj|END_ENTITY	IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors .
10956646	0	APRIL	112,117	TACI	56,60	APRIL	TACI	8741	23495	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Tumor necrosis factor -LRB- TNF -RRB- receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS .
17119122	0	APRIL	33,38	TACI	0,4	APRIL	TACI	8741	23495	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TACI regulates IgA production by APRIL in collaboration with HSPG .
22699762	0	APRIL	109,114	TACI	73,77	APRIL	TACI	8741	23495	Gene	Gene	TNFSF13|appos|START_ENTITY classifications|appos|TNFSF13 classifications|appos|TNFRSF13B TNFRSF13B|appos|END_ENTITY	Three different classifications , B lymphocyte subpopulations , TNFRSF13B -LRB- TACI -RRB- , TNFRSF13C -LRB- BAFF-R -RRB- , TNFSF13 -LRB- APRIL -RRB- gene mutations , CTLA-4 and ICOS gene polymorphisms in Turkish patients with common_variable_immunodeficiency .
23202984	0	APRIL	41,46	TACI	50,54	APRIL	TACI	8741	23495	Gene	Gene	inhibition|nmod|START_ENTITY analysis|nmod|inhibition analysis|nmod|END_ENTITY	Structural analysis of the inhibition of APRIL by TACI and BCMA through molecular dynamics simulations .
22699762	0	APRIL	109,114	TNFRSF13C	80,89	APRIL	TNFRSF13C	8741	115650	Gene	Gene	TNFSF13|appos|START_ENTITY classifications|appos|TNFSF13 classifications|appos|TNFRSF13B TNFRSF13B|appos|END_ENTITY	Three different classifications , B lymphocyte subpopulations , TNFRSF13B -LRB- TACI -RRB- , TNFRSF13C -LRB- BAFF-R -RRB- , TNFSF13 -LRB- APRIL -RRB- gene mutations , CTLA-4 and ICOS gene polymorphisms in Turkish patients with common_variable_immunodeficiency .
17307753	0	APRIL	8,13	TNFSF13	15,22	APRIL	TNFSF13	8741	8741	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of APRIL -LRB- TNFSF13 -RRB- polymorphisms in the susceptibility to systemic_lupus_erythematosus in Japanese .
24376672	0	APRIL	6,11	TWEAK	13,18	APRIL	TWEAK	8741	8742	Gene	Gene	TACI|appos|START_ENTITY TACI|appos|END_ENTITY	BAFF , APRIL , TWEAK , BCMA , TACI and Fn14 proteins are related to human glioma_tumor grade : immunohistochemistry and public microarray data meta-analysis .
26348210	0	APRIL	52,57	a_Proliferation-Inducing_Ligand	19,50	APRIL	a Proliferation-Inducing Ligand	69583(Tax:10090)	69583(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Pathogenic Role of a_Proliferation-Inducing_Ligand -LRB- APRIL -RRB- in Murine IgA Nephropathy .
26348210	0	APRIL	52,57	a_Proliferation-Inducing_Ligand	19,50	APRIL	a Proliferation-Inducing Ligand	69583(Tax:10090)	69583(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Pathogenic Role of a_Proliferation-Inducing_Ligand -LRB- APRIL -RRB- in Murine IgA Nephropathy .
3780312	0	APRT	69,73	FRA16D	123,129	APRT	FRA16D	353	2463	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	A new location for the human adenine_phosphoribosyltransferase gene -LRB- APRT -RRB- distal to the haptoglobin -LRB- HP -RRB- and fra -LRB- 16 -RRB- -LRB- q23 -RRB- -LRB- FRA16D -RRB- loci .
1746557	0	APRT	87,91	adenine_phosphoribosyltransferase	52,85	APRT	adenine phosphoribosyltransferase	353	353	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a single missense mutation in the adenine_phosphoribosyltransferase -LRB- APRT -RRB- gene from five Icelandic patients and a British patient .
3780312	0	APRT	69,73	adenine_phosphoribosyltransferase	29,62	APRT	adenine phosphoribosyltransferase	353	353	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new location for the human adenine_phosphoribosyltransferase gene -LRB- APRT -RRB- distal to the haptoglobin -LRB- HP -RRB- and fra -LRB- 16 -RRB- -LRB- q23 -RRB- -LRB- FRA16D -RRB- loci .
6087472	0	APRT	65,69	adenine_phosphoribosyltransferase	30,63	APRT	adenine phosphoribosyltransferase	353	353	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning of a functional human adenine_phosphoribosyltransferase -LRB- APRT -RRB- gene : identification of a restriction fragment length polymorphism and preliminary analysis of DNAs from APRT-deficient families and cell mutants .
9521589	0	APRT	103,107	adenine_phosphoribosyltransferase	68,101	APRT	adenine phosphoribosyltransferase	353	353	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A germline mutation abolishing the original stop codon of the human adenine_phosphoribosyltransferase -LRB- APRT -RRB- gene leads to complete loss of the enzyme protein .
11568974	0	APT1	70,74	tumor_necrosis_factor_receptor_superfamily_6	24,68	APT1	tumor necrosis factor receptor superfamily 6	355	355	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Hypermethylation of the tumor_necrosis_factor_receptor_superfamily_6 -LRB- APT1 , Fas , CD95/Apo -1 -RRB- gene promoter at rel/nuclear _ factor_kappaB sites in prostatic_carcinoma .
23183622	0	APTX	35,39	aprataxin	24,33	APTX	aprataxin	54840	54840	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel mutation in the aprataxin -LRB- APTX -RRB- gene in an Iranian individual suffering early-onset ataxia with oculomotor_apraxia_type_1 -LRB- AOA1 -RRB- _ disease .
26530238	0	APX	50,53	catalase	9,17	APX	catalase	778224(Tax:4081)	543990(Tax:4081)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Roles of catalase -LRB- CAT -RRB- and ascorbate peroxidase -LRB- APX -RRB- genes in stress response of eggplant -LRB- Solanum melongena L. -RRB- against Cu -LRB- +2 -RRB- and Zn -LRB- +2 -RRB- heavy metal stresses .
26530238	0	APX	50,53	peroxidase	38,48	APX	peroxidase	778224(Tax:4081)	543959(Tax:4081)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Roles of catalase -LRB- CAT -RRB- and ascorbate peroxidase -LRB- APX -RRB- genes in stress response of eggplant -LRB- Solanum melongena L. -RRB- against Cu -LRB- +2 -RRB- and Zn -LRB- +2 -RRB- heavy metal stresses .
7568229	0	APX-1	0,5	LAG-2	37,42	APX-1	LAG-2	178759(Tax:6239)	178755(Tax:6239)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis_elegans development .
26377038	0	AP_endonuclease_1	30,47	APE1	49,53	AP endonuclease 1	APE1	328	328	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Efficient inhibition of human AP_endonuclease_1 -LRB- APE1 -RRB- via substrate masking by abasic site-binding macrocyclic ligands .
19449863	0	AP_endonuclease_1	6,23	alkyladenine_DNA_glycosylase	70,98	AP endonuclease 1	alkyladenine DNA glycosylase	328	4350	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Human AP_endonuclease_1 stimulates multiple-turnover base excision by alkyladenine_DNA_glycosylase .
23577621	0	AP_lyase	64,72	ALKBH1	91,97	AP lyase	ALKBH1	328	8846	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	A covalent protein-DNA 5 ' - product adduct is generated following AP_lyase activity of human ALKBH1 -LRB- AlkB_homologue_1 -RRB- .
24582979	0	APeg3	0,5	Peg3	21,25	APeg3	Peg3	100169890	5178	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	APeg3 : regulation of Peg3 through an evolutionarily conserved ncRNA .
9657305	0	AQP-4	61,66	mercurial-insensitive_water_channel	24,59	AQP-4	mercurial-insensitive water channel	25293(Tax:10116)	25293(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Selective expression of mercurial-insensitive_water_channel -LRB- AQP-4 -RRB- gene in Hensen and Claudius cells in the rat cochlea .
20083182	0	AQP1	37,41	AQP2	43,47	AQP1	AQP2	25240(Tax:10116)	25386(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
20083182	0	AQP1	37,41	AQP3	49,53	AQP1	AQP3	25240(Tax:10116)	65133(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
26923194	0	AQP1	25,29	Aquaporin-1	12,23	AQP1	Aquaporin-1	358	358	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Endothelial Aquaporin-1 -LRB- AQP1 -RRB- Expression Is Regulated by Transcription Factor Mef2c .
23164158	0	AQP1	13,17	Aquaporin_1	0,11	AQP1	Aquaporin 1	358	358	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Aquaporin_1 -LRB- AQP1 -RRB- expression in experimentally induced osteoarthritic_knee_menisci : an in vivo and in vitro study .
20083182	0	AQP1	37,41	V2R	55,58	AQP1	V2R	25240(Tax:10116)	25108(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
12600999	0	AQP1	35,39	aquaporin-1	22,33	AQP1	aquaporin-1	11826(Tax:10090)	11826(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Hypertonicity-induced aquaporin-1 -LRB- AQP1 -RRB- expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene .
15351300	0	AQP1	25,29	aquaporin-1	12,23	AQP1	aquaporin-1	11826(Tax:10090)	11826(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The role of aquaporin-1 -LRB- AQP1 -RRB- expression in a murine model of lipopolysaccharide-induced acute_lung_injury .
18926811	0	AQP1	47,51	aquaporin_1	34,45	AQP1	aquaporin 1	358	358	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and immunodetection of aquaporin_1 -LRB- AQP1 -RRB- in canine spermatozoa .
20149606	0	AQP1	27,31	aquaporin_1	14,25	AQP1	aquaporin 1	358	358	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin_1 -LRB- AQP1 -RRB- in human synovitis .
7504987	0	AQP1	46,50	aquaporin_1	33,44	AQP1	aquaporin 1	358	358	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The human gene for water channel aquaporin_1 -LRB- AQP1 -RRB- is localized on chromosome 7p15 -- > p14 .
19008911	0	AQP2	25,29	AKAP220	0,7	AQP2	AKAP220	359	11215	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts .
20083182	0	AQP2	43,47	AQP1	37,41	AQP2	AQP1	25386(Tax:10116)	25240(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
15898956	0	AQP2	24,28	AQP3	98,102	AQP2	AQP3	11827(Tax:10090)	11828(Tax:10090)	Gene	Gene	channels|compound|START_ENTITY expression|nmod|channels collecting_duct|nsubj|expression collecting_duct|nmod|mice mice|nummod|END_ENTITY	Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting_duct in AQP3 null mice .
20083182	0	AQP2	43,47	AQP3	49,53	AQP2	AQP3	25386(Tax:10116)	65133(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
7525161	0	AQP2	6,10	MIP	45,48	AQP2	MIP	359	4284	Gene	Gene	START_ENTITY|appos|members members|nmod|family family|compound|END_ENTITY	Human AQP2 and MIP genes , two members of the MIP family , map within chromosome band 12q13 on the basis of two-color FISH .
20083182	0	AQP2	43,47	V2R	55,58	AQP2	V2R	25386(Tax:10116)	25108(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
20083182	0	AQP3	49,53	AQP1	37,41	AQP3	AQP1	65133(Tax:10116)	25240(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
15898956	0	AQP3	98,102	AQP2	24,28	AQP3	AQP2	11828(Tax:10090)	11827(Tax:10090)	Gene	Gene	mice|nummod|START_ENTITY collecting_duct|nmod|mice collecting_duct|nsubj|expression expression|nmod|channels channels|compound|END_ENTITY	Decreased expression of AQP2 and AQP4 water channels and Na,K-ATPase in kidney collecting_duct in AQP3 null mice .
20083182	0	AQP3	49,53	AQP2	43,47	AQP3	AQP2	65133(Tax:10116)	25386(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
24629225	0	AQP3	44,48	Aquaporin_3	31,42	AQP3	Aquaporin 3	443047(Tax:9940)	443047(Tax:9940)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of Aquaporin_3 -LRB- AQP3 -RRB- in folliculogenesis of ewes .
24462679	0	AQP3	66,70	MiR-874	0,7	AQP3	MiR-874	360	100126343	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-874 promotes intestinal_barrier_dysfunction through targeting AQP3 following intestinal ischemic_injury .
20083182	0	AQP3	49,53	V2R	55,58	AQP3	V2R	65133(Tax:10116)	25108(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
15248066	0	AQP3	39,43	aquaporin-3	26,37	AQP3	aquaporin-3	65133(Tax:10116)	65133(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Bronchiolar expression of aquaporin-3 -LRB- AQP3 -RRB- in rat lung and its dynamics in pulmonary_oedema .
17056099	0	AQP3	27,31	aquaporin_3	14,25	AQP3	aquaporin 3	360	360	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin_3 -LRB- AQP3 -RRB- in normal and neoplastic lung tissues .
27059301	0	AQP3	63,67	miR-874	91,98	AQP3	miR-874	360	100126343	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|advcl|sponging sponging|xcomp|END_ENTITY	LncRNA H19 functions as a competing endogenous RNA to regulate AQP3 expression by sponging miR-874 in the intestinal barrier .
23032072	0	AQP4	60,64	EAAT2	39,44	AQP4	EAAT2	11829(Tax:10090)	20511(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice .
18836575	0	AQP4	31,35	aquaporin-4	18,29	AQP4	aquaporin-4	361	361	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Changes in ocular aquaporin-4 -LRB- AQP4 -RRB- expression following retinal_injury .
16246454	0	AQP4	44,48	aquaporin_4	31,42	AQP4	aquaporin 4	421088(Tax:9031)	421088(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Effect of water deprivation on aquaporin_4 -LRB- AQP4 -RRB- mRNA expression in chickens -LRB- Gallus_domesticus -RRB- .
21295117	0	AQP5	37,41	AQP5	60,64	AQP5	AQP5	25241(Tax:10116)	25241(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats .
21295117	0	AQP5	60,64	AQP5	37,41	AQP5	AQP5	25241(Tax:10116)	25241(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats .
16571723	0	AQP5	11,15	TRPV4	33,38	AQP5	TRPV4	11830(Tax:10090)	63873(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	A role for AQP5 in activation of TRPV4 by hypotonicity : concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery .
16571723	0	AQP5	81,85	TRPV4	33,38	AQP5	TRPV4	11830(Tax:10090)	63873(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY role|dep|involvement role|nmod|AQP5 AQP5|nmod|activation activation|nmod|END_ENTITY	A role for AQP5 in activation of TRPV4 by hypotonicity : concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery .
18449356	0	AQP5	48,52	aquaporin-5	35,46	AQP5	aquaporin-5	362	362	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Comparative expression analysis of aquaporin-5 -LRB- AQP5 -RRB- in keratoconic and healthy corneas .
23469202	0	AQP5	51,55	aquaporin_5	38,49	AQP5	aquaporin 5	11830(Tax:10090)	11830(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hypoxia and hypoxia mimetics decrease aquaporin_5 -LRB- AQP5 -RRB- expression through both hypoxia inducible factor-1a and proteasome-mediated pathways .
17337204	0	AQP9	48,52	Aquaporin-9	35,46	AQP9	Aquaporin-9	366	366	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Stress-induced changes in neuronal Aquaporin-9 -LRB- AQP9 -RRB- in a retinal_ganglion cell-line .
20220109	0	AQP9	88,92	aquaporin-9	75,86	AQP9	aquaporin-9	366	366	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	High levels of human chorionic gonadotropin -LRB- hCG -RRB- correlate with increased aquaporin-9 -LRB- AQP9 -RRB- expression in explants from human preeclamptic placenta .
23464865	0	AQP9	32,36	aquaporin-9	19,30	AQP9	aquaporin-9	65054(Tax:10116)	65054(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Changes in retinal aquaporin-9 -LRB- AQP9 -RRB- expression in glaucoma .
18053968	0	AQP9	32,36	aquaporin_9	19,30	AQP9	aquaporin 9	65054(Tax:10116)	65054(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of brain aquaporin_9 -LRB- AQP9 -RRB- in catecholaminergic neurons in diabetic rats .
24790336	0	AR	42,44	Androgen_Receptor	23,40	AR	Androgen Receptor	367	367	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Mutational Analysis of Androgen_Receptor -LRB- AR -RRB- Gene in 46 , XY Patients with Ambiguous_Genitalia and Normal Testosterone Secretion : Endocrinological Characteristics of Three Patients with AR Gene Mutations .
12014620	0	AR	19,21	Androgen_receptor	0,17	AR	Androgen receptor	367	367	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in normal and cancerous human endometrial tissues detected by RT-PCR and immunohistochemistry .
14963700	0	AR	19,21	Androgen_receptor	0,17	AR	Androgen receptor	367	367	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression is an independent unfavorable prognostic factor in gastric_cancer .
15368471	0	AR	19,21	Androgen_receptor	0,17	AR	Androgen receptor	367	367	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in AR-negative prostate_cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic_tumors .
22289337	0	AR	19,21	Androgen_receptor	0,17	AR	Androgen receptor	367	367	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in prostate_cancer and progression of the tumor : Lessons from cell lines , animal models and human specimens .
25057438	0	AR	19,21	Androgen_receptor	0,17	AR	Androgen receptor	367	367	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in 400 breast_carcinomas : is routine AR assessment justified ?
25925349	0	AR	19,21	Androgen_receptor	0,17	AR	Androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- gene CAG trinucleotide repeat length associated with body composition measures in non-syndromic_obese , non-obese and Prader-Willi_syndrome individuals .
9344686	0	AR	19,21	Androgen_receptor	0,17	AR	Androgen receptor	24208(Tax:10116)	24208(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- immunoreactivity in rat pudendal motoneurons : implications for accessory proteins .
25178514	0	AR	0,2	ERa	21,24	AR	ERa	367	2099	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	AR collaborates with ERa in aromatase inhibitor-resistant breast_cancer .
22792352	0	AR	77,79	ESR1	42,46	AR	ESR1	367	2099	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	Microsatellites in the estrogen_receptor -LRB- ESR1 , ESR2 -RRB- and androgen_receptor -LRB- AR -RRB- genes and breast_cancer risk in African American and Nigerian women .
19389811	0	AR	42,44	Runx2	14,19	AR	Runx2	11835(Tax:10090)	12393(Tax:10090)	Gene	Gene	androgen_receptor|appos|START_ENTITY END_ENTITY|nmod|androgen_receptor	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
19389811	0	AR	42,44	Runx2	97,102	AR	Runx2	11835(Tax:10090)	12393(Tax:10090)	Gene	Gene	androgen_receptor|appos|START_ENTITY Runx2|nmod|androgen_receptor Repression|nmod|Runx2 Repression|parataxis|binds binds|dobj|END_ENTITY	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
19389811	0	AR	88,90	Runx2	14,19	AR	Runx2	11835(Tax:10090)	12393(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY Repression|parataxis|binds Repression|nmod|END_ENTITY	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
19389811	0	AR	88,90	Runx2	97,102	AR	Runx2	11835(Tax:10090)	12393(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
10493597	0	AR	50,52	androgen_receptor	31,48	AR	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of size-polymorphic androgen_receptor -LRB- AR -RRB- gene in ovarian_endometriosis according to the number of cytosine , adenine , and guanine -LRB- CAG -RRB- repeats in AR alleles .
11875111	0	AR	33,35	androgen_receptor	14,31	AR	androgen receptor	367	367	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of androgen_receptor -LRB- AR -RRB- function by the reproductive orphan nuclear receptor DAX-1 .
12600293	0	AR	61,63	androgen_receptor	42,59	AR	androgen receptor	367	367	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	-LSB- Significance of both nuclear and cytosol androgen_receptor -LRB- AR -RRB- in assessment of AR status in prostate_carcinoma and hepatocellular_carcinoma -RSB- .
14693242	0	AR	59,61	androgen_receptor	35,52	AR	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The CAG repeat polymorphism in the androgen_receptor gene -LRB- AR -RRB- and its relationship to head_and_neck_cancer .
15876692	0	AR	50,52	androgen_receptor	31,48	AR	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	CAG repeat polymorphism in the androgen_receptor -LRB- AR -RRB- gene of SBMA patients and a control group .
16804045	0	AR	71,73	androgen_receptor	52,69	AR	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The A645D mutation in the hinge region of the human androgen_receptor -LRB- AR -RRB- gene modulates AR activity , depending on the context of the polymorphic glutamine and glycine repeats .
17482664	0	AR	55,57	androgen_receptor	36,53	AR	androgen receptor	367	367	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Tissue-specific distribution of the androgen_receptor -LRB- AR -RRB- in the porcine fetus .
22428303	0	AR	71,73	androgen_receptor	52,69	AR	androgen receptor	397582(Tax:9823)	397582(Tax:9823)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prenatal exposure to antiandrogen_flutamide affects androgen_receptor -LRB- AR -RRB- expression in postnatal ovarian development in pig .
23012352	0	AR	63,65	androgen_receptor	44,61	AR	androgen receptor	11835(Tax:10090)	11835(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Targeting the unique methylation pattern of androgen_receptor -LRB- AR -RRB- promoter in prostate stem/progenitor cells with 5-aza-2 ' - deoxycytidine -LRB- 5-AZA -RRB- leads to suppressed prostate tumorigenesis .
23591144	0	AR	106,108	androgen_receptor	87,104	AR	androgen receptor	367	367	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Reciprocal interaction between melatonin receptors -LRB- Mel -LRB- 1a -RRB- , Mel -LRB- 1b -RRB- , and Mel -LRB- 1c -RRB- -RRB- and androgen_receptor -LRB- AR -RRB- expression in immunoregulation of a seasonally breeding bird , Perdicula asiatica : role of photoperiod .
24799883	0	AR	77,79	androgen_receptor	58,75	AR	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	New single nucleotide variation in the promoter region of androgen_receptor -LRB- AR -RRB- gene in hypospadic patients .
24820830	0	AR	92,94	androgen_receptor	73,90	AR	androgen receptor	367	367	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Contribution of allelic variability in prostate_specific_antigen -LRB- PSA -RRB- _ androgen_receptor -LRB- AR -RRB- genes to serum PSA levels in men with prostate_cancer .
25438607	0	AR	59,61	androgen_receptor	35,52	AR	androgen receptor	367	367	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	-LSB- Molecular genetic polymorphism of androgen_receptor gene -LRB- AR -RRB- in African populations of Hadza and Datoga -RSB- .
25508138	0	AR	59,61	androgen_receptor	35,52	AR	androgen receptor	367	367	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	-LSB- Molecular genetic polymorphism of androgen_receptor gene -LRB- AR -RRB- in African populations of Hadza and Datoga -RSB- .
7608480	0	AR	81,83	androgen_receptor	62,79	AR	androgen receptor	367	367	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Effect of androgens and their manipulation on cell growth and androgen_receptor -LRB- AR -RRB- levels in AR-positive_and _ - negative_human_hepatocellular_carcinomas .
7658727	0	AR	123,125	androgen_receptor	104,121	AR	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Quantitative non-radioactive clonality analysis of human leukemic cells and progenitors using the human androgen_receptor -LRB- AR -RRB- gene .
8329186	0	AR	32,34	androgen_receptor	13,30	AR	androgen receptor	367	367	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Detection of androgen_receptor -LRB- AR -RRB- mRNA by the reverse transcription polymerase chain reaction -LRB- RT-PCR -RRB- in human thyroids .
21525791	0	AR	91,93	neuropilin-1	95,107	AR	neuropilin-1	367	8829	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	TOFA -LRB- 5-tetradecyl-oxy-2-furoic_acid -RRB- reduces fatty_acid synthesis , inhibits expression of AR , neuropilin-1 and Mcl-1 and kills prostate_cancer cells independent of p53 status .
17408421	0	AR-A	71,75	androgen_receptor	88,105	AR-A	androgen receptor	368	367	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	Complete_androgen_insensitivity without Wolffian_duct development : the AR-A form of the androgen_receptor is not sufficient for male genital development .
9524266	0	ARA1	90,94	arabinose_kinase	96,112	ARA1	arabinose kinase	827299(Tax:3702)	827299(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Analysis of a 14-kb fragment containing a putative cell wall gene and a candidate for the ARA1 , arabinose_kinase , gene from chromosome IV of Arabidopsis_thaliana .
16778972	0	ARA55	21,26	HIC-5	15,20	ARA55	HIC-5	7041	7041	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of HIC-5 / ARA55 in colonrectal_cancer and its mechanisms of action -RSB- .
19035221	0	ARA55	7,12	Hic-5	1,6	ARA55	Hic-5	7041	7041	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	-LSB- Hic-5 / ARA55 inhibits the growth of Lovo cells by up-regulating the expression of P27 -RSB- .
21515881	0	ARA55	91,96	TR4	51,54	ARA55	TR4	7041	7182	Gene	Gene	receptor|nmod|START_ENTITY receptor|nummod|END_ENTITY	Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation .
11546764	0	ARA55	45,50	hic-5	39,44	ARA55	hic-5	7041	7041	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of hic-5 / ARA55 as an hsp27 binding protein .
11546764	0	ARA55	45,50	hsp27	57,62	ARA55	hsp27	7041	3315	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Identification and characterization of hic-5 / ARA55 as an hsp27 binding protein .
16110473	0	ARA70	80,85	Myostatin	0,9	ARA70	Myostatin	27057(Tax:10090)	17700(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Myostatin negatively regulates the expression of the steroid receptor co-factor ARA70 .
8020955	0	ARAF1	71,76	A-raf-1	57,64	ARAF1	A-raf-1	369	369	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The complete sequence and promoter activity of the human A-raf-1 gene -LRB- ARAF1 -RRB- .
22573888	0	ARAP1	0,5	Arf1	65,69	ARAP1	Arf1	116985	375	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5 .
21275903	0	ARAP1	0,5	CIN85	23,28	ARAP1	CIN85	116985	30011	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	ARAP1 association with CIN85 affects epidermal_growth_factor_receptor endocytic trafficking .
23295182	0	ARAP2	0,5	Arf6	22,26	ARAP2	Arf6	116984	382	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology .
21585041	0	ARD	81,84	acireductone_dioxygenase	55,79	ARD	acireductone dioxygenase	55256	55256	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Cloning , molecular characterization and expression of acireductone_dioxygenase -LRB- ARD -RRB- gene from Salvia miltiorrhiza -RSB- .
9671726	0	ARD1	58,62	ADP-ribosylation_factor_domain_protein_1	16,56	ARD1	ADP-ribosylation factor domain protein 1	373	373	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of ADP-ribosylation_factor_domain_protein_1 -LRB- ARD1 -RRB- in lysosomes and Golgi apparatus .
22580278	0	ARD1	0,4	RIP1	16,20	ARD1	RIP1	8260	8737	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	ARD1 binding to RIP1 mediates doxorubicin-induced NF-kB activation .
10748148	0	ARD1	97,101	cytohesin-1	41,52	ARD1	cytohesin-1	373	9267	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein -LRB- ARD1 -RRB- .
22048246	0	ARD1B	27,32	NAA11	20,25	ARD1B	NAA11	84779	84779	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of human NAA11 -LRB- ARD1B -RRB- gene is tissue-specific and is regulated by DNA methylation .
19414393	0	ARE-I	0,5	PSA	22,25	ARE-I	PSA	1475	354	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	ARE-I polymorphism on PSA gene in prostate_cancer patients of a Turkish population .
23399805	0	AREG	50,54	FGF8	56,60	AREG	FGF8	374	2253	Gene	Gene	TNF-a|compound|START_ENTITY TNF-a|appos|END_ENTITY	Cytomegalovirus-induced salivary gland pathology : AREG , FGF8 , TNF-a , and IL-6_signal_dysregulation and neoplasia .
12082524	0	ARF	14,17	E2F1	77,81	ARF	E2F1	1029	13555(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY independent|nsubj|Activation independent|nmod|END_ENTITY	Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2 .
19713937	0	ARF-BP1	17,24	Mule	25,29	ARF-BP1	Mule	10075	10075	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|END_ENTITY	Ubiquitin ligase ARF-BP1 / Mule modulates base excision repair .
21233210	0	ARF-like_protein_16	0,19	RIG-I	37,42	ARF-like protein 16	RIG-I	339231	23586	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	ARF-like_protein_16 -LRB- ARL16 -RRB- inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner .
9268368	0	ARF1	63,67	Arno	110,114	ARF1	Arno	375	9266	Gene	Gene	activation|nmod|START_ENTITY Role|nmod|activation Role|nmod|END_ENTITY	Role of protein-phospholipid interactions in the activation of ARF1 by the guanine_nucleotide exchange factor Arno .
11773070	0	ARF1	53,57	DEF-1	0,5	ARF1	DEF-1	11840(Tax:10090)	13196(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	DEF-1 / ASAP1 is a GTPase-activating protein -LRB- GAP -RRB- for ARF1 that enhances cell motility through a GAP-dependent mechanism .
21653832	0	ARF1	27,31	Gab2	0,4	ARF1	Gab2	11840(Tax:10090)	14389(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Gab2 , via PI-3K , regulates ARF1 in Fc __ RI-mediated granule translocation and mast cell degranulation .
16731582	0	ARF1	42,46	RPA	0,3	ARF1	RPA	842268(Tax:3702)	818088(Tax:3702)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	RPA , a class II ARFGAP protein , activates ARF1 and U5 and plays a role in root hair development in Arabidopsis .
23707487	0	ARF1	0,4	Rac1	14,18	ARF1	Rac1	375	5879	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast_cancer cells .
10366714	0	ARF5	67,71	ADP-ribosylation_factor_5	40,65	ARF5	ADP-ribosylation factor 5	381	381	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the human ADP-ribosylation_factor_5 -LRB- ARF5 -RRB- gene .
9169151	0	ARF5	74,78	ADP-ribosylation_factor_5	47,72	ARF5	ADP-ribosylation factor 5	381	381	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization and characterization of the human ADP-ribosylation_factor_5 -LRB- ARF5 -RRB- gene .
14659046	0	ARF6	87,91	ADP-ribosylation_factor_6	60,85	ARF6	ADP-ribosylation factor 6	382	382	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence , genomic organization , and expression of the human ADP-ribosylation_factor_6 -LRB- ARF6 -RRB- gene : a class III ARF .
17623778	0	ARF6	75,79	ARNO	70,74	ARF6	ARNO	382	9266	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	The calcium-sensing_receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network .
25450674	0	ARF6	12,16	Cytohesin_2	0,11	ARF6	Cytohesin 2	382	9266	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Cytohesin_2 / ARF6 regulates preadipocyte migration through the activation of ERK1/2 .
14668475	0	ARF6	26,30	EFA6	0,4	EFA6	EFA6	5662	5662	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	EFA6 , exchange factor for ARF6 , regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement .
16413273	0	ARF6	95,99	EFA6A	20,25	ARF6	EFA6A	382	5662	Gene	Gene	assay|appos|START_ENTITY assay|nmod|END_ENTITY	Functional assay of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 -LRB- ARF6 -RRB- , in dendritic formation of hippocampal neurons .
18708035	0	ARF6	76,80	EFA6A	28,33	ARF6	EFA6A	11845(Tax:10090)	73728(Tax:10090)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Predominant localization of EFA6A , a guanine_nucleotide exchange factor for ARF6 , at the perisynaptic photoreceptor processes .
16707115	0	ARF6	86,90	EFA6D	38,43	ARF6	EFA6D	11845(Tax:10090)	234353(Tax:10090)	Gene	Gene	factor|nmod|START_ENTITY expression|appos|factor expression|nmod|END_ENTITY	Distinct spatiotemporal expression of EFA6D , a guanine_nucleotide exchange factor for ARF6 , among the EFA6 family in mouse brain .
25450674	0	ARF6	12,16	ERK1/2	76,82	ARF6	ERK1/2	382	5595;5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Cytohesin_2 / ARF6 regulates preadipocyte migration through the activation of ERK1/2 .
18814847	0	ARF6	79,83	Endothelin-1	0,12	ARF6	Endothelin-1	382	1906	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity .
25799492	0	ARF6	0,4	Epidermal_Growth_Factor	118,141	ARF6	Epidermal Growth Factor	382	1950	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|nmod|END_ENTITY	ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast_Cancer Cells in Response to Epidermal_Growth_Factor .
25347845	0	ARF6	8,12	Hsp90	33,38	ARF6	Hsp90	382	3320	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of ARF6 , Rab11 and External Hsp90 in the Trafficking and Recycling of Recombinant-Soluble Neisseria_meningitidisAdhesin A -LRB- rNadA -RRB- in Human Epithelial Cells .
19211056	0	ARF6	0,4	JIP4	20,24	ARF6	JIP4	382	9043	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis .
19644450	0	ARF6	75,79	JIP4	98,102	ARF6	JIP4	382	9043	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	The structural basis of Arf effector specificity : the crystal structure of ARF6 in a complex with JIP4 .
11481345	0	ARF6	14,18	Rac1	102,106	ARF6	Rac1	382	5879	Gene	Gene	Activation|nmod|START_ENTITY stimulates|nsubj|Activation stimulates|nmod|activation activation|nmod|END_ENTITY	Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase_D .
17122362	0	ARF6	11,15	Rac1	31,35	ARF6	Rac1	382	5879	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Endogenous ARF6 interacts with Rac1 upon angiotensin_II stimulation to regulate membrane ruffling and cell migration .
25799492	0	ARF6	0,4	Rac1	31,35	ARF6	Rac1	382	5879	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|dobj|Formation Formation|nmod|END_ENTITY	ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast_Cancer Cells in Response to Epidermal_Growth_Factor .
23555901	0	ARF6	0,4	glucosylceramide_synthase	46,71	ARF6	glucosylceramide synthase	11845(Tax:10090)	22234(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	ARF6 regulates neuron differentiation through glucosylceramide_synthase .
23836931	0	ARH	0,3	megalin	12,19	ARH	megalin	26119	4036	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|END_ENTITY	ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression .
11854031	0	ARHGAP12	32,40	rhoGAP	56,62	ARHGAP12	rhoGAP	94134	392	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Cloning and characterization of ARHGAP12 , a novel human rhoGAP gene .
21865595	0	ARHGAP18	0,8	RhoA	42,46	ARHGAP18	RhoA	93663	387	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	ARHGAP18 , a GTPase-activating protein for RhoA , controls cell shape , spreading , and motility .
18662671	0	ARHGAP21	0,8	FAK	25,28	ARHGAP21	FAK	307178(Tax:10116)	25614(Tax:10116)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload .
24067935	0	ARHGAP26	16,24	ADAR1	0,5	ARHGAP26	ADAR1	23092	103	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ADAR1 regulates ARHGAP26 gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding .
25961434	0	ARHGAP5	124,131	MiR-744	0,7	ARHGAP5	MiR-744	394	100126313	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	MiR-744 functions as a proto-oncogene in nasopharyngeal_carcinoma progression and metastasis via transcriptional control of ARHGAP5 .
17897297	0	ARHGDIB	29,36	LyGDI	22,27	ARHGDIB	LyGDI	397	397	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Loss of expression of LyGDI -LRB- ARHGDIB -RRB- , a rho GDP-dissociation inhibitor , in Hodgkin_lymphoma .
21139582	0	ARHGEF16	50,58	Tip-1	29,34	ARHGEF16	Tip-1	27237	30851	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16 , which activates Cdc42 .
21715309	0	ARHGEF3	46,53	RhoA	13,17	ARHGEF3	RhoA	570228(Tax:7955)	100006041(Tax:7955)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Silencing of RhoA nucleotide exchange factor , ARHGEF3 , reveals its unexpected role in iron uptake .
25500533	0	ARHGEF7	112,119	LRRK2	19,24	ARHGEF7	LRRK2	54126(Tax:10090)	66725(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of LRRK2 by casein kinase 1a regulates trans-Golgi clustering via differential interaction with ARHGEF7 .
15475444	0	ARHI	40,44	p21WAF1/CIP1	117,129	ARHI	p21WAF1/CIP1	9077	1026	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|expression expression|nmod|END_ENTITY	Expression of the tumor suppressor gene ARHI in epithelial_ovarian_cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival .
20496121	0	ARIA	22,26	AtNEK6	0,6	ARIA	AtNEK6	641700	823542(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	AtNEK6 interacts with ARIA and is involved in ABA response during seed germination .
22408686	0	ARID1A	17,23	BAF-250a	25,33	ARID1A	BAF-250a	8289	8289	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Does the Loss of ARID1A -LRB- BAF-250a -RRB- Expression in Endometrial_Clear_Cell_Carcinomas Have Any Clinicopathologic Significance ?
24557437	0	ARID1A	59,65	BAF250a	50,57	ARID1A	BAF250a	8289	8289	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The clinicopathologic significance of the loss of BAF250a -LRB- ARID1A -RRB- expression in endometrial_carcinoma .
26589513	0	ARID1A	47,53	BAF250a	38,45	ARID1A	BAF250a	8289	8289	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	The Clinicopathologic Significance of BAF250a -LRB- ARID1A -RRB- Expression in Hepatocellular_Carcinoma .
26953344	0	ARID1A	13,19	TERT	46,50	ARID1A	TERT	8289	7015	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells .
23524907	0	ARID1A	56,62	p53	38,41	ARID1A	p53	8289	7157	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The clinicopathologic significance of p53 and BAF-250a -LRB- ARID1A -RRB- expression in clear cell carcinoma_of_the_endometrium .
23887303	0	ARID1A	0,6	p53	66,69	ARID1A	p53	8289	7157	Gene	Gene	loss|compound|START_ENTITY correlates|nsubj|loss correlates|nmod|expression expression|compound|END_ENTITY	ARID1A loss correlates with mismatch_repair_deficiency and intact p53 expression in high-grade endometrial_carcinomas .
27035278	0	ARID2	82,87	MicroRNA-155	0,12	ARID2	MicroRNA-155	196528	406947	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-155 promotes tumor growth of human hepatocellular_carcinoma by targeting ARID2 .
15273717	0	ARK5	59,63	caspase-6	14,23	ARK5	caspase-6	9891	839	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of caspase-6 and FLIP by the AMPK family member ARK5 .
14693054	0	ARL-1	116,121	aldose_reductase_like_gene-1	86,114	ARL-1	aldose reductase like gene-1	400	400	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Screening of the drug resistance-associated gene in HepG2 cell line transfected with aldose_reductase_like_gene-1 -LRB- ARL-1 -RRB- -RSB- .
12527357	0	ARL2	60,64	HRG4	31,35	ARL2	HRG4	402	9094	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Photoreceptor synaptic protein HRG4 -LRB- UNC119 -RRB- interacts with ARL2 via a putative conserved domain .
22159419	0	ARL4A	0,5	GCC185	16,22	ARL4A	GCC185	101928788	9648	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	ARL4A acts with GCC185 to modulate Golgi complex organization .
17804820	0	ARL4D	0,5	ARNO	27,31	ARL4D	ARNO	379	9266	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	ARL4D recruits cytohesin-2 / ARNO to modulate actin remodeling .
24601692	0	ARMC5	87,92	armadillo_repeat_containing_5	56,85	ARMC5	armadillo repeat containing 5	79798	79798	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Macronodular_adrenal_hyperplasia due to mutations in an armadillo_repeat_containing_5 -LRB- ARMC5 -RRB- gene : a clinical and genetic investigation .
19304657	0	ARMCX3	41,47	Sox10	128,133	ARMCX3	Sox10	71703(Tax:10090)	20665(Tax:10090)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	The armadillo repeat-containing protein , ARMCX3 , physically and functionally interacts with the developmental regulatory factor Sox10 .
22219653	0	ARMS2	195,200	age-related_maculopathy_susceptibility_2	148,188	ARMS2	age-related maculopathy susceptibility 2	387715	387715	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Difference between age-related_macular_degeneration and polypoidal_choroidal_vasculopathy in the hereditary contribution of the A69S variant of the age-related_maculopathy_susceptibility_2 gene -LRB- ARMS2 -RRB- .
17623778	0	ARNO	70,74	ARF6	75,79	ARNO	ARF6	9266	382	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	The calcium-sensing_receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network .
17804820	0	ARNO	27,31	ARL4D	0,5	ARNO	ARL4D	9266	379	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	ARL4D recruits cytohesin-2 / ARNO to modulate actin remodeling .
21276423	0	ARNO	36,40	Arf_nucleotide_binding_site_opener	0,34	ARNO	Arf nucleotide binding site opener	116692(Tax:10116)	116692(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Arf_nucleotide_binding_site_opener -LSB- ARNO -RSB- promotes sequential activation of Arf6 , Cdc42 and Rac1 and insulin secretion in INS 832/13 b-cells and rat islets .
26378252	0	ARNO	20,24	Cytohesin-2	8,19	ARNO	Cytohesin-2	9266	9266	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	ARF-GEF Cytohesin-2 / ARNO regulates R-Ras and a5-integrin recycling through an EHD1-positive compartment .
20525696	0	ARNO	12,16	paxillin	78,86	ARNO	paxillin	19158(Tax:10090)	19303(Tax:10090)	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Cytohesin-2 / ARNO , through its interaction with focal adhesion adaptor protein paxillin , regulates preadipocyte migration via the downstream activation of Arf6 .
10363132	0	ARNO3	24,29	PSCD3	36,41	ARNO3	PSCD3	9265	9265	Gene	Gene	gene|compound|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of the human ARNO3 gene -LRB- PSCD3 -RRB- to chromosome 7p21 by radiation hybrid mapping .
10048155	0	ARNT	30,34	AHR	25,28	ARNT	AHR	11863(Tax:10090)	11622(Tax:10090)	Gene	Gene	GR|appos|START_ENTITY GR|compound|END_ENTITY	RT-PCR quantification of AHR , ARNT , GR , and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone .
10619402	0	ARNT	62,66	AHR	31,34	ARNT	AHR	405	196	Gene	Gene	heterodimer|appos|START_ENTITY heterodimer|compound|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|appos|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- heterodimer interacts with naturally occurring estrogen response elements .
10619402	0	ARNT	62,66	AHR	36,39	ARNT	AHR	405	196	Gene	Gene	heterodimer|appos|START_ENTITY heterodimer|compound|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|dep|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- heterodimer interacts with naturally occurring estrogen response elements .
10728779	0	ARNT	119,123	AHR	84,87	ARNT	AHR	25242(Tax:10116)	25690(Tax:10116)	Gene	Gene	aromatic_hydrocarbon_receptor|appos|START_ENTITY aromatic_hydrocarbon_receptor|appos|END_ENTITY	Estrous cycle-dependent changes in the expression of aromatic_hydrocarbon_receptor -LRB- AHR -RRB- and AHR-nuclear translocator -LRB- ARNT -RRB- mRNAs in the rat ovary and liver .
11368516	0	ARNT	155,159	AHR	124,127	ARNT	AHR	405	196	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
11368516	0	ARNT	155,159	AHR	129,132	ARNT	AHR	405	196	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|dep|translocator translocator|dep|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
15114261	0	ARNT	98,102	AHR	41,44	ARNT	AHR	405	196	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AHR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- ARNT -RRB- mRNA expression in human spermatozoa .
16111922	0	ARNT	62,66	AHR	36,39	ARNT	AHR	405	196	Gene	Gene	translocator|appos|START_ENTITY translocator|compound|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AHR -RRB- and AHR nuclear translocator -LRB- ARNT -RRB- expression in Baikal_seal -LRB- Pusa_sibirica -RRB- and association with 2,3,7,8-TCDD toxic equivalents and CYP1 expression levels .
9882441	0	ARNT	101,105	ARNT2	68,73	ARNT	ARNT2	100136759(Tax:8022)	105921182	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|nmod|form	Functional diversity of vertebrate ARNT proteins : identification of ARNT2 as the predominant form of ARNT in the marine teleost , Fundulus_heteroclitus .
11179451	0	ARNT	58,62	AhR	27,30	ARNT	AhR	405	196	Gene	Gene	activity|appos|START_ENTITY unaltered|nsubj|activity Aryl_hydrocarbon|parataxis|unaltered Aryl_hydrocarbon|dep|receptor receptor|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- / AhR nuclear translocator -LRB- ARNT -RRB- activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded -LRB- PAS -RRB- - region serine residue .
11179451	0	ARNT	58,62	AhR	32,35	ARNT	AhR	405	196	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- / AhR nuclear translocator -LRB- ARNT -RRB- activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded -LRB- PAS -RRB- - region serine residue .
22981438	0	ARNT	20,24	AhR	31,34	ARNT	AhR	405	196	Gene	Gene	START_ENTITY|nmod|manner manner|compound|END_ENTITY	SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4 + CD8 + DPK thymocytes differentiation .
9759704	0	ARNT	106,110	AhR	45,48	ARNT	AhR	405	196	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- and the aryl_hydrocarbon_receptor nuclear translocator -LRB- ARNT -RRB- in fetal , benign hyperplastic , and malignant prostate .
8244375	0	ARNT	43,47	Ah_receptor_nuclear_translocator	4,36	ARNT	Ah receptor nuclear translocator	405	405	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Ah_receptor_nuclear_translocator gene -LRB- ARNT -RRB- is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3 .
25812120	0	ARNT	33,37	Aryl_Hydrocarbon_Receptor_Nuclear_Translocator	39,85	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	Results|amod|START_ENTITY Results|appos|END_ENTITY	Hepatocyte - Specific Deletion of ARNT -LRB- Aryl_Hydrocarbon_Receptor_Nuclear_Translocator -RRB- Results in Altered Fibrotic Gene Expression in the Thioacetamide Model of Liver_Injury .
18366646	0	ARNT	48,52	Aryl_hydrocarbon_receptor_nuclear_translocator	0,46	ARNT	Aryl hydrocarbon receptor nuclear translocator	405	405	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits : Mutation detection , case-control studies , and gene expression analysis .
24136190	0	ARNT	71,75	aryl_hydrocarbon_receptor	45,70	ARNT	aryl hydrocarbon receptor	100379223(Tax:10141)	100192396(Tax:10141)	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Nucleotide specificity of DNA binding of the aryl_hydrocarbon_receptor : ARNT complex is unaffected by ligand structure .
10721670	0	ARNT	59,63	aryl_hydrocarbon_receptor_nuclear_translocator	6,52	ARNT	aryl hydrocarbon receptor nuclear translocator	405	405	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human aryl_hydrocarbon_receptor_nuclear_translocator gene -LRB- ARNT -RRB- D/N511 polymorphism .
11074397	0	ARNT	95,99	aryl_hydrocarbon_receptor_nuclear_translocator	47,93	ARNT	aryl hydrocarbon receptor nuclear translocator	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Expression and subcellular localization of the aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- protein in mouse and chicken over developmental time .
14961334	0	ARNT	62,66	aryl_hydrocarbon_receptor_nuclear_translocator	14,60	ARNT	aryl hydrocarbon receptor nuclear translocator	100136759(Tax:8022)	100136759(Tax:8022)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- isoforms in juvenile and adult rainbow_trout tissues .
8662957	0	ARNT	64,68	aryl_hydrocarbon_receptor_nuclear_translocator	16,62	ARNT	aryl hydrocarbon receptor nuclear translocator	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- in hypoxic induction of gene expression .
25017895	0	ARNT	62,66	hypoxia-inducible_factor_1-beta	29,60	ARNT	hypoxia-inducible factor 1-beta	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Differential distribution of hypoxia-inducible_factor_1-beta -LRB- ARNT or ARNT2 -RRB- in mouse substantia nigra and ventral tegmental area .
9882441	0	ARNT2	68,73	ARNT	101,105	ARNT2	ARNT	105921182	100136759(Tax:8022)	Gene	Gene	START_ENTITY|nmod|form form|nmod|END_ENTITY	Functional diversity of vertebrate ARNT proteins : identification of ARNT2 as the predominant form of ARNT in the marine teleost , Fundulus_heteroclitus .
24847962	0	ARNTL2	20,26	BMAL2	28,33	ARNTL2	BMAL2	56938	56938	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The polymorphism of ARNTL2 -LRB- BMAL2 -RRB- gene rs2306074 C > T is associated with susceptibility of Alzheimer_disease in Chinese population .
11025203	0	ARNT_interacting_protein	48,72	AINT	34,38	ARNT interacting protein	AINT	21335(Tax:10090)	21335(Tax:10090)	Gene	Gene	Isolation|dep|START_ENTITY Isolation|nmod|END_ENTITY	Isolation and characterization of AINT : a novel ARNT_interacting_protein expressed during murine embryonic development .
1899293	0	ARP-1	44,49	apolipoprotein_AI	18,35	ARP-1	apolipoprotein AI	7026	335	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of the apolipoprotein_AI gene by ARP-1 , a novel member of the steroid receptor superfamily .
18307387	0	ARRDC4	78,84	arrestin_domain-containing_4	43,71	ARRDC4	arrestin domain-containing 4	91947	91947	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An anomalous haplotype distribution of the arrestin_domain-containing_4 gene -LRB- ARRDC4 -RRB- haplotypes in Caucasians .
19699491	0	ARSA	41,45	Arylsulfatase_A	24,39	ARSA	Arylsulfatase A	410	410	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Identification of a new Arylsulfatase_A -LRB- ARSA -RRB- gene mutation in Tunisian patients with metachromatic_leukodystrophy -LRB- MLD -RRB- .
24243352	0	ARSB	119,123	Arylsulfatase_B	102,117	ARSB	Arylsulfatase B	411	411	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Molecular Analysis of Turkish Maroteaux-Lamy Patients and Identification of One Novel Mutation in the Arylsulfatase_B -LRB- ARSB -RRB- Gene .
26609033	0	ARSB	41,45	arylsulphatase_B	23,39	ARSB	arylsulphatase B	411	411	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations of the arylsulphatase_B -LRB- ARSB -RRB- gene in Indian patients with mucopolysaccharidosis_type_VI .
20679209	0	ARSG	26,30	Arylsulfatase_G	9,24	ARSG	Arylsulfatase G	22901	22901	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A canine Arylsulfatase_G -LRB- ARSG -RRB- mutation leading to a sulfatase_deficiency is associated with neuronal_ceroid_lipofuscinosis .
25825126	0	ARSG	54,58	arylsulfatase_G	37,52	ARSG	arylsulfatase G	22901	22901	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Accumulation of rare variants in the arylsulfatase_G -LRB- ARSG -RRB- gene in task-specific dystonia .
19262745	0	ARSI	41,45	arylsulfatase_I	24,39	ARSI	arylsulfatase I	340075	340075	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the arylsulfatase_I -LRB- ARSI -RRB- gene preferentially expressed in the human retinal pigment epithelium cell line ARPE-19 .
27985	0	ARS_A	29,34	arylsulfatase_A	12,27	ARS A	arylsulfatase A	410	410	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of arylsulfatase_A -LRB- ARS_A -RRB- in multiple sulfatase deficiency_disorder_fibroblasts .
16934346	0	ART3	77,81	mono-ADP-ribosyltransferase	49,76	ART3	mono-ADP-ribosyltransferase	419	419	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene .
26149390	0	ARTD1	0,5	interleukin_6	17,30	ARTD1	interleukin 6	142	3569	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	ARTD1 suppresses interleukin_6 expression by repressing MLL1-dependent histone H3 trimethylation .
22060274	0	ARTEMIN	0,7	TWIST1	24,30	ARTEMIN	TWIST1	9048	7291	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	ARTEMIN synergizes with TWIST1 to promote metastasis and poor survival outcome in patients with ER negative mammary_carcinoma .
17613295	0	ARX	55,58	Aristaless-related_homeobox	26,53	ARX	Aristaless-related homeobox	170302	170302	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation screening of the Aristaless-related_homeobox -LRB- ARX -RRB- gene in Thai pediatric patients with delayed development : first report from Thailand .
21496008	0	ARX	85,88	Aristaless-related_homeobox	56,83	ARX	Aristaless-related homeobox	170302	170302	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Screening and cell-based assessment of mutations in the Aristaless-related_homeobox -LRB- ARX -RRB- gene .
15319782	1	ARX	100,103	Aristaless_X	105,117	ARX	Aristaless X	170302	170302	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	The paradox of the ARX -LRB- Aristaless_X -RRB- mutations .
15850492	0	ARX	78,81	Aristaless_related_homeobox	83,110	ARX	Aristaless related homeobox	170302	170302	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	XLMR in MRX families 29 , 32 , 33 and 38 results from the dup24 mutation in the ARX -LRB- Aristaless_related_homeobox -RRB- gene .
25074490	0	ARX	99,102	aristaless-related_homeobox	70,97	ARX	aristaless-related homeobox	170302	170302	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A child with a novel de novo mutation in the aristaless domain of the aristaless-related_homeobox -LRB- ARX -RRB- gene presenting with ambiguous_genitalia and psychomotor delay .
21340166	0	ARYL_hydrocarbon_receptor_interacting_protein	71,116	AIP	118,121	ARYL hydrocarbon receptor interacting protein	AIP	9049	9049	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aggressive_prolactinoma in a child related to germline mutation in the ARYL_hydrocarbon_receptor_interacting_protein -LRB- AIP -RRB- gene .
15034716	0	AS1	61,64	AS2	66,69	AS1	AS2	818340(Tax:3702)	842873(Tax:3702)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	ERECTA is required for protection against heat-stress in the AS1 / AS2 pathway to regulate adaxial-abaxial leaf polarity in Arabidopsis .
23271976	0	AS1	57,60	HDA6	20,24	AS1	HDA6	818340(Tax:3702)	836431(Tax:3702)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Histone deacetylase HDA6 is functionally associated with AS1 in repression of KNOX genes in arabidopsis .
22689584	0	AS160	41,46	AS160	57,62	AS160	AS160	9882	9882	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation .
22689584	0	AS160	57,62	AS160	41,46	AS160	AS160	9882	9882	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation .
21613213	0	AS160	8,13	Akt	14,17	AS160	Akt	9882	207	Gene	Gene	substrate|compound|START_ENTITY substrate|compound|END_ENTITY	Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes .
21454505	0	AS160	47,52	TBC1D4	39,45	AS160	TBC1D4	9882	9882	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Crystal structures of human TBC1D1 and TBC1D4 -LRB- AS160 -RRB- RabGTPase-activating protein -LRB- RabGAP -RRB- domains reveal critical elements for GLUT4 translocation .
22466139	0	AS160	62,67	TBC1D4	54,60	AS160	TBC1D4	210789(Tax:10090)	210789(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunofluorescent localization of the Rab-GAP protein TBC1D4 -LRB- AS160 -RRB- in mouse kidney .
22732222	0	AS160	25,30	TBC1D4	17,23	AS160	TBC1D4	9882	9882	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Affinity between TBC1D4 -LRB- AS160 -RRB- phosphotyrosine-binding domain and insulin-regulated_aminopeptidase cytoplasmic domain measured by isothermal titration calorimetry .
15034716	0	AS2	66,69	AS1	61,64	AS2	AS1	842873(Tax:3702)	818340(Tax:3702)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	ERECTA is required for protection against heat-stress in the AS1 / AS2 pathway to regulate adaxial-abaxial leaf polarity in Arabidopsis .
17485849	0	AS2/LOB	83,90	LATERAL_ORGAN_BOUNDARIES	92,116	AS2/LOB	LATERAL ORGAN BOUNDARIES	842873;836429	836429(Tax:3702)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	A link between cytokinin and ASL9 -LRB- ASYMMETRIC_LEAVES_2_LIKE_9 -RRB- that belongs to the AS2/LOB -LRB- LATERAL_ORGAN_BOUNDARIES -RRB- family genes in Arabidopsis_thaliana .
25461954	0	AS3MT	71,76	arsenite_methyltransferase_gene	38,69	AS3MT	arsenite methyltransferase gene	57412	57412	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Family-based association study of the arsenite_methyltransferase_gene -LRB- AS3MT , rs11191454 -RRB- in Korean children with attention-deficit_hyperactivity_disorder .
17925329	0	ASAP	0,4	Aurora-A	58,66	ASAP	Aurora-A	79884	6790	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A : phosphorylation on Ser625 is essential to spindle formation and mitosis .
22672907	0	ASAP	13,17	MAP9	19,23	ASAP	MAP9	79884	79884	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of ASAP -LRB- MAP9 -RRB- contributes to p53 stabilization in response to DNA damage .
12522101	0	ASAP1	13,18	CrkL	0,4	ASAP1	CrkL	50807	1399	Gene	Gene	directs|dobj|START_ENTITY directs|nsubj|END_ENTITY	CrkL directs ASAP1 to peripheral focal adhesions .
18685082	0	ASAP1	30,35	FIP3	66,70	ASAP1	FIP3	50807	8517	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome .
21352810	0	ASAP1	12,17	GEFH1	0,5	ASAP1	GEFH1	50807	9181	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	GEFH1 binds ASAP1 and regulates podosome formation .
16325183	0	ASB	0,3	Cullin5	27,34	ASB	Cullin5	212	8065	Gene	Gene	proteins|compound|START_ENTITY interact|nsubj|proteins interact|nmod|END_ENTITY	ASB proteins interact with Cullin5 and Rbx2 to form E3_ubiquitin_ligase complexes .
18799729	0	ASB2	0,4	filamins_A_and_B	13,29	ASB2	filamins A and B	51676	2316;2317	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	ASB2 targets filamins_A_and_B to proteasomal degradation .
20302626	0	ASB9	0,4	ubiquitous_mitochondrial_creatine_kinase	20,60	ASB9	ubiquitous mitochondrial creatine kinase	140462	1159	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ASB9 interacts with ubiquitous_mitochondrial_creatine_kinase and inhibits mitochondrial function .
16150853	0	ASBT	80,84	apical_sodium_dependent_bile_acid_transporter	33,78	ASBT	apical sodium dependent bile acid transporter	6555	6555	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Adaptive regulation of the ileal apical_sodium_dependent_bile_acid_transporter -LRB- ASBT -RRB- in patients with obstructive cholestasis .
22934972	0	ASC	59,62	Apoptosis-associated_speck-like_protein_containing_a_CARD	0,57	ASC	Apoptosis-associated speck-like protein containing a CARD	29108	29108	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Apoptosis-associated_speck-like_protein_containing_a_CARD -LRB- ASC -RRB- expression profiles in familial_Mediterranean_fever -LRB- FMF -RRB- patients with different MEFV mutation patterns .
25847972	0	ASC	51,54	MAVS	0,4	ASC	MAVS	29108	57506	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3 .
15096476	0	ASC	59,62	PYNOD	0,5	ASC	PYNOD	29108	338322	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	PYNOD , a novel Apaf-1 / CED4-like protein is an inhibitor of ASC and caspase-1 .
17165436	0	ASCL2	20,25	HASH2	13,18	ASCL2	HASH2	430	430	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of HASH2 -LRB- ASCL2 -RRB- gene expression in gestational_trophoblastic_disease .
26444490	0	ASCT2	62,67	Alanine-Serine-Cysteine_Transporter	25,60	ASCT2	Alanine-Serine-Cysteine Transporter	6510	6510	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Ligand Discovery for the Alanine-Serine-Cysteine_Transporter -LRB- ASCT2 , SLC1A5 -RRB- from Homology Modeling and Virtual Screening .
15845389	0	ASCT2	82,87	SGK1	29,33	ASCT2	SGK1	6510	6446	Gene	Gene	stimulate|dobj|START_ENTITY stimulate|nsubj|END_ENTITY	The serine/threonine kinases SGK1 , 3 and PKB stimulate the amino_acid transporter ASCT2 .
18570009	0	ASF	34,37	anti-secretory_factor	11,32	ASF	anti-secretory factor	6426	6426	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of anti-secretory_factor -LRB- ASF -RRB- on irritable_bowel_syndrome -LRB- IBS -RRB- .
18439897	0	ASF	24,27	splicing_factor_SF2	4,23	ASF	splicing factor SF2	6426	55147	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	The splicing_factor_SF2 / ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1 .
12826680	0	ASF/SF2	93,100	9G8	88,91	ASF/SF2	9G8	6426	6432	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	The CD44 alternative v9 exon contains a splicing enhancer responsive to the SR proteins 9G8 , ASF/SF2 , and SRp20 .
18855599	0	ASGPR	72,77	asialoglycoprotein_receptor	43,70	ASGPR	asialoglycoprotein receptor	432	432	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Targeted delivery of macromolecular drugs : asialoglycoprotein_receptor -LRB- ASGPR -RRB- expression by selected hepatoma cell lines used in antiviral drug development .
17588515	0	ASH1	26,30	Khd1p	75,80	ASH1	Khd1p	853650(Tax:4932)	852248(Tax:4932)	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p .
17978851	0	ASHR3	35,40	ABORTED_MICROSPORES	124,143	ASHR3	ABORTED MICROSPORES	829210(Tax:3702)	816194(Tax:3702)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The Arabidopsis SET-domain protein ASHR3 is involved in stamen development and interacts with the bHLH transcription factor ABORTED_MICROSPORES -LRB- AMS -RRB- .
18662336	0	ASIC	14,18	ASIC4	31,36	ASIC	ASIC4	41	55515	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Regulation of ASIC activity by ASIC4 -- new insights into ASIC channel function revealed by a yeast two-hybrid assay .
18662336	0	ASIC	56,60	ASIC4	31,36	ASIC	ASIC4	41	55515	Gene	Gene	function|compound|START_ENTITY insights|nmod|function Regulation|dep|insights Regulation|nmod|activity activity|nmod|END_ENTITY	Regulation of ASIC activity by ASIC4 -- new insights into ASIC channel function revealed by a yeast two-hybrid assay .
16505147	0	ASIC	41,45	acid-sensing_ion_channel	15,39	ASIC	acid-sensing ion channel	41	41	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of acid-sensing_ion_channel -LRB- ASIC -RRB- 1 with the tarantula toxin psalmotoxin 1 is state dependent .
17878160	0	ASIC2	85,90	Hsc70	31,36	ASIC2	Hsc70	40	3312	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cells .
18310515	0	ASIC2	29,34	Hsc70	0,5	ASIC2	Hsc70	40	3312	Gene	Gene	expression|compound|START_ENTITY regulates|xcomp|expression regulates|nsubj|END_ENTITY	Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration .
12399460	0	ASIC2a	57,63	Protein_kinase_C	0,16	ASIC2a	Protein kinase C	40	112476	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Protein_kinase_C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1 .
21257308	0	ASIC3	107,112	acid-sensing_ion_channel_3	79,105	ASIC3	acid-sensing ion channel 3	286920(Tax:10116)	286920(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	High concentration electrophysiology-based fragment screen : discovery of novel acid-sensing_ion_channel_3 -LRB- ASIC3 -RRB- inhibitors .
18662336	0	ASIC4	31,36	ASIC	14,18	ASIC4	ASIC	55515	41	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of ASIC activity by ASIC4 -- new insights into ASIC channel function revealed by a yeast two-hybrid assay .
18662336	0	ASIC4	31,36	ASIC	56,60	ASIC4	ASIC	55515	41	Gene	Gene	activity|nmod|START_ENTITY Regulation|nmod|activity Regulation|dep|insights insights|nmod|function function|compound|END_ENTITY	Regulation of ASIC activity by ASIC4 -- new insights into ASIC channel function revealed by a yeast two-hybrid assay .
15726415	0	ASIP	50,54	agouti_signaling_protein	24,48	ASIP	agouti signaling protein	434	434	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 8818G allele of the agouti_signaling_protein -LRB- ASIP -RRB- gene is ancestral and is associated with darker skin color in African Americans .
20004240	0	ASIP	57,61	agouti_signaling_protein	31,55	ASIP	agouti signaling protein	100144328(Tax:9986)	100144328(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the rabbit agouti_signaling_protein -LRB- ASIP -RRB- gene : transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour .
20016133	0	ASIP	78,82	agouti_signaling_protein	52,76	ASIP	agouti signaling protein	100860915	100860915	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Copy number variation and missense mutations of the agouti_signaling_protein -LRB- ASIP -RRB- gene in goat breeds with different coat colors .
22554923	0	ASIP	59,63	agouti_signaling_protein	33,57	ASIP	agouti signaling protein	419147(Tax:9031)	419147(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Conserved distal promoter of the agouti_signaling_protein -LRB- ASIP -RRB- gene controls sexual_dichromatism in chickens .
23661018	0	ASIP	83,87	agouti_signaling_protein	57,81	ASIP	agouti signaling protein	100860915	100860915	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the agouti_signaling_protein -LRB- ASIP -RRB- gene in some goat breeds in tropical and temperate climates .
17700517	0	ASK1	119,123	14-3-3	107,113	ASK1	14-3-3	4217	10971	Gene	Gene	dissociating|nmod|START_ENTITY dissociating|dobj|END_ENTITY	G1 to S phase transition protein 1 induces apoptosis_signal-regulating_kinase_1 activation by dissociating 14-3-3 from ASK1 .
12813029	0	ASK1	32,36	AIP1	0,4	ASK1	AIP1	4217	153090	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 .
25391652	0	ASK1	46,50	Apoptosis_Signal-regulating_Kinase_1	8,44	ASK1	Apoptosis Signal-regulating Kinase 1	4217	4217	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Apoptosis_Signal-regulating_Kinase_1 -LRB- ASK1 -RRB- as an Activator of the GAPDH-Siah1 Stress-Signaling Cascade .
15629441	0	ASK1	17,21	CaMKII	0,6	ASK1	CaMKII	4217	818	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy .
23504235	0	ASK1	17,21	CaMKII	0,6	ASK1	CaMKII	4217	818	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	CaMKII activates ASK1 to induce apoptosis of spinal astrocytes under oxygen-glucose deprivation .
9743501	0	ASK1	52,56	Daxx	81,85	ASK1	Daxx	4217	1616	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by the adapter protein Daxx .
12556535	0	ASK1	109,113	IGF-IR	44,50	ASK1	IGF-IR	4217	3480	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Type 1 insulin-like_growth_factor receptor -LRB- IGF-IR -RRB- signaling inhibits apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- .
23102700	0	ASK1	68,72	KLHDC10	25,32	ASK1	KLHDC10	4217	23008	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5 .
25485581	0	ASK1	107,111	MPK38	63,68	ASK1	MPK38	26408(Tax:10090)	17279(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A crucial role for the phosphorylation of STRAP at Ser -LRB- 188 -RRB- by MPK38 in STRAP-dependent cell death through ASK1 , TGF-b , p53 , and PI3K/PDK1 signaling pathways .
23087182	0	ASK1	18,22	MiR-20a	0,7	ASK1	MiR-20a	4217	406982	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes .
22609355	0	ASK1	40,44	Microspherule_protein_2	0,23	ASK1	Microspherule protein 2	4217	10445	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Microspherule_protein_2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation .
11689443	0	ASK1	32,36	PP5	63,66	ASK1	PP5	4217	5536	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Negative feedback regulation of ASK1 by protein phosphatase_5 -LRB- PP5 -RRB- in response to oxidative stress .
22095282	0	ASK1	45,49	PRMT1	63,68	ASK1	PRMT1	4217	3276	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Arginine methylation-dependent regulation of ASK1 signaling by PRMT1 .
16897472	0	ASK1	0,4	SKP1	8,12	ASK1	SKP1	843928(Tax:3702)	843928(Tax:3702)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	ASK1 , a SKP1 homolog , is required for nuclear reorganization , presynaptic homolog juxtaposition and the proper distribution of cohesin during meiosis in Arabidopsis .
25485581	0	ASK1	107,111	STRAP	42,47	ASK1	STRAP	26408(Tax:10090)	20901(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A crucial role for the phosphorylation of STRAP at Ser -LRB- 188 -RRB- by MPK38 in STRAP-dependent cell death through ASK1 , TGF-b , p53 , and PI3K/PDK1 signaling pathways .
9774977	0	ASK1	0,4	TRAF2	45,50	ASK1	TRAF2	4217	7186	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	ASK1 is essential for JNK/SAPK activation by TRAF2 .
12089063	0	ASK1	21,25	Thioredoxin	0,11	ASK1	Thioredoxin	4217	7295	Gene	Gene	ubiquitination|compound|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner .
17724081	0	ASK1	173,177	Thioredoxin	0,11	ASK1	Thioredoxin	4217	7295	Gene	Gene	interaction|nmod|START_ENTITY modulation|nmod|interaction regulate|nmod|modulation regulate|nsubj|proteins proteins|amod|END_ENTITY	Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1 .
17724081	0	ASK1	94,98	Thioredoxin	0,11	ASK1	Thioredoxin	4217	7295	Gene	Gene	activation|nmod|START_ENTITY regulate|dobj|activation regulate|nsubj|proteins proteins|amod|END_ENTITY	Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1 .
23747528	0	ASK1	35,39	Thioredoxin	0,11	ASK1	Thioredoxin	26408(Tax:10090)	22166(Tax:10090)	Gene	Gene	MPK38-induced|nummod|START_ENTITY function|nsubj|MPK38-induced inhibits|ccomp|function inhibits|nsubj|END_ENTITY	Thioredoxin inhibits MPK38-induced ASK1 , TGF-b , and p53 function in a phosphorylation-dependent manner .
26660634	0	ASK1	119,123	Thioredoxin	93,104	ASK1	Thioredoxin	4217	7295	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting_Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis .
12165419	0	ASK1	76,80	apoptosis_signal-regulating_kinase_1	38,74	ASK1	apoptosis signal-regulating kinase 1	365057(Tax:10116)	365057(Tax:10116)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation and autophosphorylation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- following cerebral_ischemia in rat hippocampus .
25882527	0	ASK1	56,60	apoptosis_signal-regulating_kinase_1	18,54	ASK1	apoptosis signal-regulating kinase 1	4217	4217	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Identification of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1 ,5 - dihydro-pyrrol-2-one .
9743501	0	ASK1	52,56	apoptosis_signal-regulating_kinase_1	14,50	ASK1	apoptosis signal-regulating kinase 1	4217	4217	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by the adapter protein Daxx .
12556535	0	ASK1	109,113	insulin-like_growth_factor	7,33	ASK1	insulin-like growth factor	4217	3479	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Type 1 insulin-like_growth_factor receptor -LRB- IGF-IR -RRB- signaling inhibits apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- .
10688666	0	ASK1	52,56	thioredoxin	162,173	ASK1	thioredoxin	4217	7295	Gene	Gene	apoptosis_signal-regulating_kinase_1|dep|START_ENTITY factor|amod|apoptosis_signal-regulating_kinase_1 Activation|nmod|factor receptor-associated|nsubj|Activation receptor-associated|ccomp|requires requires|dobj|dissociation dissociation|nmod|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin .
25037217	0	ASK1	96,100	thioredoxin	134,145	ASK1	thioredoxin	4217	7295	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Biophysical and structural characterization of the thioredoxin-binding domain of protein kinase ASK1 and its interaction with reduced thioredoxin .
19069379	0	ASK_1	47,52	apoptosis_signal-regulating_kinase_1	9,45	ASK 1	apoptosis signal-regulating kinase 1	4217	4217	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	-LSB- Role of apoptosis_signal-regulating_kinase_1 -LRB- ASK_1 -RRB- - mediated signaling pathway during ischemic_retinal_injury -RSB- .
12708028	0	ASK_2	91,96	apoptosis_signal-regulating_kinase_2	53,89	ASK 2	apoptosis signal-regulating kinase 2	53608(Tax:10090)	53608(Tax:10090)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Genomic organization and promoter analysis of mouse apoptosis_signal-regulating_kinase_2 -LRB- ASK_2 -RRB- -RSB- .
9812171	0	ASL	50,53	adenylosuccinate_lyase	26,48	ASL	adenylosuccinate lyase	158	158	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Determination of p185 and adenylosuccinate_lyase -LRB- ASL -RRB- activity in preneoplastic colon_lesions and intestinal mucosa of human subjects .
24166829	0	ASL	66,69	argininosuccinate_lyase	41,64	ASL	argininosuccinate lyase	435	435	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations and polymorphisms in the human argininosuccinate_lyase -LRB- ASL -RRB- gene .
26809095	0	ASMase	53,59	SMPD1	61,66	ASMase	SMPD1	6609	6609	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Resveratrol-induced transcriptional up-regulation of ASMase -LRB- SMPD1 -RRB- of human leukemia and cancer cells .
24268318	0	ASNS	23,27	Asparagine_synthetase	0,21	ASNS	Asparagine synthetase	440	440	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Asparagine_synthetase -LRB- ASNS -RRB- gene polymorphism is associated with the outcome of childhood acute_lymphoblastic_leukemia by affecting early response to treatment .
18582861	0	ASP4	0,4	dipeptidyl_peptidase_4	30,52	ASP4	dipeptidyl peptidase 4	9476	1803	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	ASP4 ,000 , a novel , selective , dipeptidyl_peptidase_4 inhibitor with antihyperglycemic activity .
21633703	0	ASPM	76,80	UBE3A	26,31	ASPM	UBE3A	259266	7337	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Angelman_syndrome protein UBE3A interacts with primary_microcephaly protein ASPM , localizes to centrosomes and regulates chromosome segregation .
18061561	0	ASPP	11,15	C-terminal_Src_kinase	26,47	ASPP	C-terminal Src kinase	37422(Tax:7227)	41398(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Drosophila ASPP regulates C-terminal_Src_kinase activity .
21183427	0	ASPP-2	68,74	apoptosis_stimulating_protein	37,66	ASPP-2	apoptosis stimulating protein	7159	7159	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cell type specific expression of the apoptosis_stimulating_protein -LRB- ASPP-2 -RRB- in human tissues .
25660448	0	ASPP1	30,35	C-Nap1	60,66	ASPP1	C-Nap1	23368	11190	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly .
16314841	0	ASPP1	0,5	TP53	29,33	ASPP1	TP53	23368	7157	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	ASPP1 , a common activator of TP53 , is inactivated by aberrant methylation of its promoter in acute_lymphoblastic_leukemia .
18793611	0	ASPP2	22,27	BAX	73,76	ASPP2	BAX	7159	581	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
18793611	0	ASPP2	22,27	DDA3	11,15	ASPP2	DDA3	7159	84722	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
12694406	0	ASPP2	0,5	NEDD8	32,37	ASPP2	NEDD8	7159	4738	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis .
21189257	0	ASPP2	20,25	PP1	0,3	ASPP2	PP1	7159	5464	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ .
20619750	0	ASPP2	0,5	Par-3	12,17	ASPP2	Par-3	7159	56288	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development .
18793611	0	ASPP2	22,27	p53	0,3	ASPP2	p53	7159	7157	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
19006241	0	ASS1	71,75	argininosuccinate_synthetase	41,69	ASS1	argininosuccinate synthetase	445	445	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations and polymorphisms in the human argininosuccinate_synthetase -LRB- ASS1 -RRB- gene .
26615011	0	AST	35,38	Aspartate_Transaminase	11,33	AST	Aspartate Transaminase	26503	26503	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	High serum Aspartate_Transaminase -LRB- AST -RRB- levels on day 3 post liver transplantation correlates with graft and patient survival and would be a valid surrogate for outcome in liver transplantation clinical trials .
8866310	0	AST	28,31	Aspartate_aminotransferase	0,26	AST	Aspartate aminotransferase	26503	26503	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Aspartate_aminotransferase -LRB- AST -RRB- levels in human periodontium-derived cells .
12887345	0	AST	38,41	aspartate_aminotransferase	10,36	AST	aspartate aminotransferase	26503	26503	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of aspartate_aminotransferase -LRB- AST -RRB- in saliva of patients with different periodontal conditions .
15899678	0	AST	69,72	aspartate_aminotransferase	41,67	AST	aspartate aminotransferase	26503	26503	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	A reference material for traceability of aspartate_aminotransferase -LRB- AST -RRB- results .
6426132	0	AST	46,49	aspartate_aminotransferase	18,44	AST	aspartate aminotransferase	26503	26503	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Relation between aspartate_aminotransferase -LRB- AST -RRB- activity in the seminal fluid and indicators of boar ejaculate quality -RSB- .
20573900	0	ASTN1	83,88	Astn2	0,5	ASTN1	Astn2	460	23245	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Astn2 , a novel member of the astrotactin gene family , regulates the trafficking of ASTN1 during glial-guided neuronal migration .
24465546	0	ASXL1	0,5	TET2	14,18	ASXL1	TET2	171023	54790	Gene	Gene	START_ENTITY|nmod|mutations mutations|nummod|END_ENTITY	ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases .
22822207	0	ASYMMETRIC_LEAVES2	44,62	JAGGED_LATERAL_ORGANS	12,33	ASYMMETRIC LEAVES2	JAGGED LATERAL ORGANS	842873(Tax:3702)	828084(Tax:3702)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Arabidopsis JAGGED_LATERAL_ORGANS acts with ASYMMETRIC_LEAVES2 to coordinate KNOX and PIN expression in shoot and root meristems .
12776518	0	AT-1	73,77	AngII_receptor	57,71	AT-1	AngII receptor	24180(Tax:10116)	24180(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	-LSB- Effect of zishuijianghuoyin on expression of lymphocyte AngII_receptor -LRB- AT-1 -RRB- mRNA of experimental hypertension rats -RSB- .
17142345	0	AT1	9,12	ANG_II	59,65	AT1	ANG II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|nmod|END_ENTITY	Enhanced AT1 receptor-mediated vasocontractile response to ANG_II in endothelium-denuded aorta of obese Zucker rats .
8032651	0	AT1	65,68	AT1B	50,54	AT1	AT1B	185	81638(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Comparative pharmacology of recombinant rat AT1A , AT1B and human AT1 receptors expressed by transfected COS-M6 cells .
23946289	0	AT1	50,53	AT2	15,18	AT1	AT2	24180(Tax:10116)	24182(Tax:10116)	Gene	Gene	increases|nummod|START_ENTITY attenuates|dobj|increases attenuates|nsubj|activation activation|compound|END_ENTITY	Angiotensin_II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin : a multiphoton microscopy study .
18182223	0	AT1	176,179	Ang_II_receptor_type_1	152,174	AT1	Ang II receptor type 1	185	185	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Angiotensin_II _ -LRB- Ang_II -RRB- evoked secretion of the human_placental_lactogen -LRB- HPL -RRB- in intrauterine_growth_retardation : examination of the relationship with Ang_II_receptor_type_1 -LRB- AT1 -RRB- expression .
10484450	0	AT1	96,99	Angiotensin_II	0,14	AT1	Angiotensin II	185	183	Gene	Gene	receptors|nummod|START_ENTITY growth|nmod|receptors activates|dobj|growth activates|nsubj|END_ENTITY	Angiotensin_II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT1 receptors .
10693967	0	AT1	90,93	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY astrocytes|nmod|receptor ATPase|nmod|astrocytes activity|dep|ATPase modulates|dobj|activity modulates|nsubj|END_ENTITY	Angiotensin_II modulates the activity of Na + , K + - ATPase in cultured rat astrocytes via the AT1 receptor and protein_kinase_C-delta activation .
11369817	0	AT1	124,127	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	mice|compound|START_ENTITY cells|nmod|mice activates|dobj|cells activates|nsubj|END_ENTITY	Angiotensin_II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice .
12028439	0	AT1	69,72	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY activates|nmod|receptors activates|nsubj|END_ENTITY	Angiotensin_II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors .
12056548	0	AT1	42,45	Angiotensin_II	0,14	AT1	Angiotensin II	185	183	Gene	Gene	bound|nmod|START_ENTITY bound|nsubjpass|END_ENTITY	Angiotensin_II is bound to both receptors AT1 and AT2 , parallel to the transmembrane domains and in an extended form .
12623987	0	AT1	29,32	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Angiotensin_II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR .
1338078	0	AT1	136,139	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY cells|nmod|receptor expression|nmod|cells increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells via the angiotensin_II AT1 receptor .
14744924	0	AT1	91,94	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY stimulates|nmod|receptors stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates calcium and nitric_oxide release from Macula densa cells through AT1 receptors .
15143297	0	AT1	15,18	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Angiotensin_II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats .
15153562	0	AT1	20,23	Angiotensin_II	0,14	AT1	Angiotensin II	11607(Tax:10090)	11606(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Angiotensin_II , via AT1 and AT2 receptors and NF-kappaB pathway , regulates the inflammatory response in unilateral_ureteral_obstruction .
1554376	0	AT1	111,114	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	exerts|nmod|START_ENTITY exerts|nsubj|END_ENTITY	Angiotensin_II exerts its effect on aldosterone production and potassium permeability through receptor subtype AT1 in rat adrenal glomerulosa cells .
16522324	0	AT1	96,99	Angiotensin_II	0,14	AT1	Angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY crosstalk|nmod|receptors cascade|nmod|crosstalk regulates|dobj|cascade regulates|nsubj|END_ENTITY	Angiotensin_II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic_scars .
17081374	0	AT1	122,125	Angiotensin_II	1,15	AT1	Angiotensin II	185	183	Gene	Gene	-RSB-|compound|START_ENTITY roles|nmod|-RSB- expression|dep|roles expression|compound|END_ENTITY	-LSB- Angiotensin_II up-regulates expression of inducible nitric_oxide synthase in human umbilical endothelial cells : roles of AT1 and AT2 -RSB- .
1878151	0	AT1	57,60	Angiotensin_II	1,15	AT1	Angiotensin II	185	183	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|nsubj|receptors receptors|compound|END_ENTITY	-LSB- Angiotensin_II receptors in the human placenta are type AT1 -RSB- .
21109230	0	AT1	89,92	Angiotensin_II	0,14	AT1	Angiotensin II	11607(Tax:10090)	11606(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY pathway|nmod|receptor induces|nmod|pathway induces|nsubj|END_ENTITY	Angiotensin_II induces interleukin-6 synthesis in osteoblasts through ERK1/2 pathway via AT1 receptor .
22128421	0	AT1	51,54	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY vasoconstriction|nmod|receptors augments|dobj|vasoconstriction augments|nsubj|END_ENTITY	Angiotensin_II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats .
22128423	0	AT1	91,94	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY role|nmod|receptor response|dep|role response|compound|END_ENTITY	Angiotensin_II pressor response in the L-NAME-induced hypertensive pithed rat : role of the AT1 receptor .
23946289	0	AT1	50,53	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	increases|nummod|START_ENTITY attenuates|dobj|increases attenuates|nsubj|activation activation|compound|END_ENTITY	Angiotensin_II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin : a multiphoton microscopy study .
25109430	0	AT1	116,119	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY sympathoexcitation|nmod|receptor contributes|xcomp|sympathoexcitation contributes|nsubj|END_ENTITY	Angiotensin_II in paraventricular nucleus contributes to sympathoexcitation in renal_ischemia-reperfusion injury by AT1 receptor and oxidative stress .
25172944	0	AT1	119,122	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY cells|nmod|receptors carotid|nsubj|cells carotid|dep|mobilizes mobilizes|nsubj|END_ENTITY	Angiotensin_II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors .
25365520	0	AT1	46,49	Angiotensin_II	58,72	AT1	Angiotensin II	185	24179(Tax:10116)	Gene	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Transcriptional Network Analysis Reveals that AT1 and AT2 Angiotensin_II Receptors Are Both Involved in the Regulation of Genes Essential for Glioma Progression .
25429176	0	AT1	35,38	Angiotensin_II	20,34	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Blockade of Central Angiotensin_II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats .
25431019	0	AT1	31,34	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY acting|nmod|receptors END_ENTITY|acl|acting	Angiotensin_II acting on brain AT1 receptors induces adrenaline secretion and pressor responses in the rat .
25808928	0	AT1	70,73	Angiotensin_II	20,34	AT1	Angiotensin II	185	183	Gene	Gene	Selectivity|compound|START_ENTITY Involved|nmod|Selectivity Determinants|xcomp|Involved Determinants|nsubj|Characterization Characterization|nmod|Molecular Molecular|compound|END_ENTITY	Characterization of Angiotensin_II Molecular Determinants Involved in AT1 Receptor Functional Selectivity .
26613735	0	AT1	21,24	Angiotensin_II	6,20	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Brain Angiotensin_II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive_alterations .
7476884	0	AT1	57,60	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY down-regulates|dobj|receptor down-regulates|nsubj|END_ENTITY	Angiotensin_II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms : evidence for homologous and heterologous regulation .
7704434	0	AT1	92,95	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|effects effects|compound|END_ENTITY	Angiotensin_II effects on second messengers involved in prolactin secretion are mediated by AT1 receptor in anterior pituitary cells .
7881045	0	AT1	15,18	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Angiotensin_II AT1 receptor mediated contraction of the perfused rat cerebral artery .
8124662	0	AT1	100,103	Angiotensin_II	0,14	AT1	Angiotensin II	185	183	Gene	Gene	receptors|nummod|START_ENTITY activation|nmod|receptors cells|nmod|activation calcium|nmod|cells elevates|dobj|calcium elevates|nsubj|END_ENTITY	Angiotensin_II elevates cytosolic free calcium in human lung_adenocarcinoma cells via activation of AT1 receptors .
8127007	0	AT1	110,113	Angiotensin_II	0,14	AT1	Angiotensin II	185	183	Gene	Gene	binding|nmod|START_ENTITY receptors|amod|binding stimulates|nmod|receptors stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates human fetal mesangial cell proliferation and fibronectin biosynthesis by binding to AT1 receptors .
8394907	0	AT1	96,99	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY cyclase|nmod|receptor inhibits|dobj|cyclase inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits glomerular adenylate cyclase via the angiotensin_II receptor subtype 1 -LRB- AT1 -RRB- .
8566350	0	AT1	48,51	Angiotensin_II	0,14	AT1	Angiotensin II	185	183	Gene	Gene	subtype|compound|START_ENTITY exclusively|nmod|subtype cells|advmod|exclusively cells|nsubj|receptors receptors|compound|END_ENTITY	Angiotensin_II receptors are exclusively of the AT1 subtype in cultured human vascular smooth muscle cells .
8950291	0	AT1	33,36	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY action|nmod|receptors END_ENTITY|nmod|action	Angiotensin_II , via an action at AT1 receptors , may modulate the behavioural effects of ET-1 in conscious rats .
9003008	0	AT1	33,36	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	down-regulated|nsubjpass|START_ENTITY subtypes|ccomp|down-regulated subtypes|nsubj|receptor receptor|compound|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9003008	0	AT1	90,93	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY down-regulated|nmod|receptor subtypes|ccomp|down-regulated subtypes|nsubj|receptor receptor|compound|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9709394	0	AT1	32,35	Angiotensin_II	0,14	AT1	Angiotensin II	185	183	Gene	Gene	expression|compound|START_ENTITY subtype|dobj|expression subtype|nsubj|receptor receptor|compound|END_ENTITY	Angiotensin_II receptor subtype AT1 and AT2 expression after heart transplantation .
9791081	0	AT1	23,26	Angiotensin_II	0,14	AT1	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY acts|nmod|receptors acts|nsubj|END_ENTITY	Angiotensin_II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex .
11959040	0	AT1	26,29	Angiotensin_II_subtype_1	0,24	AT1	Angiotensin II subtype 1	24180(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Angiotensin_II_subtype_1 -LRB- AT1 -RRB- receptors contribute to ischemic_contracture and regulate chemomechanical energy transduction in isolated transgenic rat -LRB- alphaMHC-hAT1 -RRB- 594-17 hearts .
26445208	1	AT1	146,149	Nox4	177,181	AT1	Nox4	11607(Tax:10090)	50490(Tax:10090)	Gene	Gene	Associates|compound|START_ENTITY Associates|nmod|END_ENTITY	AT1 Physically Associates With Nox4 .
10079018	0	AT1	60,63	angiotensin_II	45,59	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	correction|compound|START_ENTITY correction|compound|END_ENTITY	Binding of the antagonist -LSB- 3H -RSB- candesartan to angiotensin_II AT1 receptor-transfected -LSB- correction of tranfected -RSB- Chinese_hamster ovary cells .
10193788	0	AT1	142,145	angiotensin_II	127,141	AT1	angiotensin II	24180(Tax:10116)	183	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin_II AT1 receptors .
10193788	0	AT1	62,65	angiotensin_II	127,141	AT1	angiotensin II	24180(Tax:10116)	183	Gene	Gene	receptor|compound|START_ENTITY Distinction|nmod|receptor antagonists|nsubj|Distinction antagonists|xcomp|expressing expressing|dobj|receptors receptors|amod|END_ENTITY	Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin_II AT1 receptors .
10194764	0	AT1	85,88	angiotensin_II	121,135	AT1	angiotensin II	185	183	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|analogs analogs|nmod|END_ENTITY	Determination of peptide contact points in the human angiotensin_II type I receptor -LRB- AT1 -RRB- with photosensitive analogs of angiotensin_II .
10194764	0	AT1	85,88	angiotensin_II	53,67	AT1	angiotensin II	185	183	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|points points|nmod|receptor receptor|amod|END_ENTITY	Determination of peptide contact points in the human angiotensin_II type I receptor -LRB- AT1 -RRB- with photosensitive analogs of angiotensin_II .
10201881	0	AT1	58,61	angiotensin_II	11,25	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	blockade|compound|START_ENTITY generation|nmod|blockade generation|amod|END_ENTITY	Intrarenal angiotensin_II generation and renal effects of AT1 receptor blockade .
10415517	0	AT1	107,110	angiotensin_II	17,31	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY overexpression|nmod|receptor signaling|nmod|overexpression Amplification|acl|signaling Amplification|nmod|END_ENTITY	Amplification of angiotensin_II signaling in cardiac myocytes by adenovirus-mediated overexpression of the AT1 receptor .
10443311	0	AT1	39,42	angiotensin_II	24,38	AT1	angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	-LSB- Are the antagonists of angiotensin_II AT1 receptors protectors of the kidney ? -RSB- .
10682705	0	AT1	22,25	angiotensin_II	7,21	AT1	angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Gerbil angiotensin_II AT1 receptors are highly expressed in the hippocampus and cerebral cortex during postnatal development .
11327630	0	AT1	19,22	angiotensin_II	4,18	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	irbesartan|nummod|START_ENTITY irbesartan|compound|END_ENTITY	The angiotensin_II AT1 receptor antagonist irbesartan prevents thromboxane_A2-induced vasoconstriction in the rat hind-limb vascular bed in vivo .
11697745	0	AT1	29,32	angiotensin_II	84,98	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	blockers|compound|START_ENTITY administration|nmod|blockers administration|nmod|END_ENTITY	Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin_II and sodium .
11861115	0	AT1	96,99	angiotensin_II	81,95	AT1	angiotensin II	185	183	Gene	Gene	antagonist|compound|START_ENTITY antagonist|amod|END_ENTITY	Structure elucidation and conformational properties of eprosartan , a non peptide angiotensin_II AT1 antagonist .
11963637	0	AT1	33,36	angiotensin_II	37,51	AT1	angiotensin II	185	183	Gene	Gene	antagonists|nummod|START_ENTITY antagonists|amod|END_ENTITY	-LSB- Efficacy-safety relationship of AT1 angiotensin_II receptor antagonists : current data -RSB- .
12006574	1	AT1	153,156	angiotensin_II	131,145	AT1	angiotensin II	185	183	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Distinct roles of the N-and C-terminal residues of angiotensin_II during AT1 receptor activation .
12127057	0	AT1	0,3	angiotensin_II	4,18	AT1	angiotensin II	185	183	Gene	Gene	receptor|nummod|START_ENTITY receptor|compound|END_ENTITY	AT1 angiotensin_II receptor mediates intracellular calcium mobilization in normal and cancerous breast cells in primary culture .
12215602	0	AT1	147,150	angiotensin_II	132,146	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY antagonist|amod|END_ENTITY	Protection against ischemia and improvement of cerebral_blood_flow in genetically hypertensive rats by chronic pretreatment with an angiotensin_II AT1 antagonist .
12235231	0	AT1	26,29	angiotensin_II	43,57	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY receptor|nmod|END_ENTITY	Nonpeptide antagonists of AT1 receptor for angiotensin_II delay the onset of acute_respiratory_distress_syndrome .
12602118	0	AT1	11,14	angiotensin_II	44,58	AT1	angiotensin II	185	183	Gene	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	Effects of AT1 and AT2 receptor blockade on angiotensin_II induced apoptosis of human renal proximal tubular epithelial cells .
12686508	0	AT1	44,47	angiotensin_II	29,43	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	antagonism|nummod|START_ENTITY antagonism|compound|END_ENTITY	Anti-inflammatory effects of angiotensin_II AT1 receptor antagonism prevent stress-induced gastric_injury .
12848769	0	AT1	111,114	angiotensin_II	96,110	AT1	angiotensin II	185	183	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Angiotensin_II dose-effect curves and Schild regression plots for characterization of different angiotensin_II AT1 receptor antagonists in clinical pharmacology .
1331171	0	AT1	62,65	angiotensin_II	47,61	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Balloon angioplasty enhances the expression of angiotensin_II AT1 receptors in neointima of rat aorta .
1338078	0	AT1	136,139	angiotensin_II	121,135	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Angiotensin_II increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells via the angiotensin_II AT1 receptor .
14624277	0	AT1	23,26	angiotensin_II	8,22	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Role of angiotensin_II AT1 receptor blockers in the treatment of arterial hypertension .
1480133	0	AT1	113,116	angiotensin_II	88,102	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Characterization of the binding of -LSB- 3H -RSB- L-158 ,809 : a new potent and selective nonpeptide angiotensin_II receptor -LRB- AT1 -RRB- antagonist radioligand .
1504808	0	AT1	88,91	angiotensin_II	57,71	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY involvement|nmod|receptors Modulation|dep|involvement Modulation|nmod|current current|nmod|neurons neurons|nmod|END_ENTITY	Modulation of net outward current in cultured neurons by angiotensin_II : involvement of AT1 and AT2 receptors .
15120479	0	AT1	19,22	angiotensin_II	67,81	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY Mutagenesis|nmod|receptor reveals|nsubj|Mutagenesis reveals|dobj|modes modes|nmod|END_ENTITY	Mutagenesis of the AT1 receptor reveals different binding modes of angiotensin_II and -LSB- Sar1 -RSB- - angiotensin_II .
15120479	0	AT1	19,22	angiotensin_II	93,107	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY Mutagenesis|nmod|receptor reveals|nsubj|Mutagenesis reveals|dobj|modes modes|dep|END_ENTITY	Mutagenesis of the AT1 receptor reveals different binding modes of angiotensin_II and -LSB- Sar1 -RSB- - angiotensin_II .
15148525	0	AT1	76,79	angiotensin_II	14,28	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY jaw_movements|nmod|receptors enhances|dobj|jaw_movements enhances|nsubj|END_ENTITY	Evidence that angiotensin_II enhances apomorphine-induced jaw_movements via AT1 receptors in the ventrolateral striatum : studies by magnet-sensing system in freely moving rats .
15501693	0	AT1	76,79	angiotensin_II	36,50	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY contraction|nmod|receptors mediated|dobj|contraction mediated|nsubj|END_ENTITY	High glucose concentration augments angiotensin_II mediated contraction via AT1 receptors in rat thoracic aorta .
15639476	0	AT1	0,3	angiotensin_II	86,100	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|dep|coupling coupling|nmod|supersensitivity supersensitivity|nmod|END_ENTITY	AT1 receptors and L-type calcium channels : functional coupling in supersensitivity to angiotensin_II in diabetic rats .
15680481	0	AT1	123,126	angiotensin_II	93,107	AT1	angiotensin II	185	183	Gene	Gene	antagonists|amod|START_ENTITY reversed|nmod|antagonists reversed|nsubjpass|inhibition inhibition|nmod|ATPase ATPase|nmod|concentrations concentrations|nmod|END_ENTITY	Protein kinase C-mediated inhibition of renal Ca2 + ATPase by physiological concentrations of angiotensin_II is reversed by AT1 - and AT2-receptor antagonists .
15953595	0	AT1	54,57	angiotensin_II	58,72	AT1	angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Functional evidence that in the cardiovascular system AT1 angiotensin_II receptors are AT1B prejunctionally and AT1A postjunctionally .
16061493	0	AT1	27,30	angiotensin_II	12,26	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Presynaptic angiotensin_II AT1 receptors enhance inhibitory and excitatory synaptic neurotransmission to motoneurons and other ventral horn neurons in neonatal rat spinal cord .
16112405	0	AT1	16,19	angiotensin_II	92,106	AT1	angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY Coexpression|nmod|receptors associated|nsubjpass|Coexpression associated|nmod|END_ENTITY	Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin_II .
16126915	0	AT1	60,63	angiotensin_II	8,22	AT1	angiotensin II	11607(Tax:10090)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY consumption|nmod|receptor controls|dobj|consumption controls|nsubj|END_ENTITY	Central angiotensin_II controls alcohol consumption via its AT1 receptor .
1618259	0	AT1	100,103	angiotensin_II	46,60	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	DuP_753|compound|START_ENTITY blocked|nmod|DuP_753 blocked|nsubjpass|Drinking Drinking|acl|induced induced|nmod|injection injection|nmod|END_ENTITY	Drinking induced by subcutaneous injection of angiotensin_II in the rat is blocked by the selective AT1 receptor antagonist DuP_753 but not by the selective AT2 receptor antagonist WL_19 .
16205776	0	AT1	46,49	angiotensin_II	31,45	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	A centrally acting , anxiolytic angiotensin_II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding .
16443499	0	AT1	53,56	angiotensin_II	37,51	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY END_ENTITY|appos|receptor	Agonistic antibodies directed at the angiotensin_II , AT1 receptor in preeclampsia .
16542148	0	AT1	97,100	angiotensin_II	82,96	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	A role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin_II AT1 receptor .
16542179	0	AT1	60,63	angiotensin_II	45,59	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Immunohistochemical localization of distinct angiotensin_II AT1 receptor isoforms in the kidneys of the Sprague-Dawley_rat and the desert rodent Meriones crassus .
16565729	0	AT1	39,42	angiotensin_II	87,101	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY cysteine|nmod|receptor S-nitrosylation|nmod|cysteine decreases|nsubj|S-nitrosylation decreases|dobj|affinity affinity|nmod|END_ENTITY	S-nitrosylation of cysteine 289 of the AT1 receptor decreases its binding affinity for angiotensin_II .
16601219	0	AT1	0,3	angiotensin_II	42,56	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	blockade|nummod|START_ENTITY regulates|nsubj|blockade regulates|dobj|system system|compound|END_ENTITY	AT1 receptor blockade regulates the local angiotensin_II system in cerebral microvessels from spontaneously hypertensive rats .
17004728	0	AT1	125,128	angiotensin_II	63,77	AT1	angiotensin II	185	183	Gene	Gene	affinity|nmod|START_ENTITY forming|nmod|affinity END_ENTITY|acl|forming	Design , synthesis , and incorporation of a_beta-turn mimetic in angiotensin_II forming novel pseudopeptides with affinity for AT1 and AT2 receptors .
17010318	0	AT1	78,81	angiotensin_II	62,76	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|immunohistochemistry immunohistochemistry|nmod|END_ENTITY	The use of heat-induced hydrolysis in immunohistochemistry on angiotensin_II -LRB- AT1 -RRB- receptors enhances the immunoreactivity in paraformaldehyde-fixed brain tissue of normotensive Sprague-Dawley_rats .
17118791	0	AT1	91,94	angiotensin_II	56,70	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY photolabel|nmod|receptor photolabel|nmod|END_ENTITY	Synthesis of an agonistic , difluoro-azido photolabel of angiotensin_II and labeling of the AT1 receptor : transmembrane domains 3 , 6 , and 7 form the ligand-binding pocket .
17239455	0	AT1	60,63	angiotensin_II	45,59	AT1	angiotensin II	185	183	Gene	Gene	transduction|compound|START_ENTITY transduction|amod|END_ENTITY	Participation of transmembrane_proline 82 in angiotensin_II AT1 receptor signal transduction .
1750504	0	AT1	63,66	angiotensin_II	47,61	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY END_ENTITY|appos|receptor	Angiotensin-converting_enzyme inhibitor versus angiotensin_II , AT1 receptor antagonist .
17855497	0	AT1	76,79	angiotensin_II	46,60	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY mediated|nmod|receptors mediated|nsubjpass|modulation modulation|acl|circulating circulating|dobj|END_ENTITY	Baroreceptor reflex modulation by circulating angiotensin_II is mediated by AT1 receptors in the nucleus tractus solitarius .
17879628	0	AT1	43,46	angiotensin_II	28,42	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Estimation of the number of angiotensin_II AT1 receptors in rat kidney afferent and efferent arterioles .
18310294	0	AT1	84,87	angiotensin_II	69,83	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Anti-cancer actions of a recombinant antibody -LRB- R6313/G2 -RRB- against the angiotensin_II AT1 receptor .
18567710	0	AT1	136,139	angiotensin_II	76,90	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY availability|nmod|receptors increasing|dobj|availability upregulates|advcl|increasing upregulates|nmod|END_ENTITY	High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin_II by increasing the functional availability of AT1 receptors .
19407469	0	AT1	77,80	angiotensin_II	14,28	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY effect|nmod|receptor effect|nmod|END_ENTITY	The effect of angiotensin_II on the number of macula_densa cells through the AT1 receptor .
19726542	0	AT1	0,3	angiotensin_II	32,46	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|dobj|uptake uptake|nmod|END_ENTITY	AT1 receptor-mediated uptake of angiotensin_II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway .
20659889	0	AT1	122,125	angiotensin_II	107,121	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Tumor necrosis factor receptor-associated factor-6 and ribosomal_S6_kinase intracellular pathways link the angiotensin_II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells .
21143281	0	AT1	52,55	angiotensin_II	25,39	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nsubj|actions actions|nmod|END_ENTITY	Physiological actions of angiotensin_II mediated by AT1 AND AT2 receptors in the brain .
24927350	0	AT1	61,64	angiotensin_II	38,52	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|immunization immunization|nmod|type type|compound|END_ENTITY	Effect of active immunization against angiotensin_II type 1 -LRB- AT1 -RRB- receptor on hypertension _ arterial remodelling in spontaneously hypertensive rats -LRB- SHR -RRB- .
25003108	0	AT1	75,78	angiotensin_II	60,74	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Fear-potentiated behaviour is modulated by central amygdala angiotensin_II AT1 receptors stimulation .
25218469	0	AT1	105,108	angiotensin_II	121,135	AT1	angiotensin II	185	183	Gene	Gene	receptor|nummod|START_ENTITY receptor|nmod|END_ENTITY	Down-regulation of ether-a-go-go-related gene potassium channel protein through sustained stimulation of AT1 receptor by angiotensin_II .
25238020	0	AT1	12,15	angiotensin_II	56,70	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	pathways|nsubj|START_ENTITY pathways|xcomp|END_ENTITY	Endothelial AT1 and AT2 pathways in aortic responses to angiotensin_II after stress and ethanol consumption in rats .
25682288	0	AT1	20,23	angiotensin_II	32,46	AT1	angiotensin II	185	183	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association between AT1 and AT2 angiotensin_II receptor expression with cell proliferation and angiogenesis in operable breast_cancer .
26268856	0	AT1	68,71	angiotensin_II	42,56	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|expression expression|nmod|receptors receptors|amod|END_ENTITY	Changes in protein and gene expression of angiotensin_II receptors -LRB- AT1 and AT2 -RRB- in aorta of diabetic and hypertensive rats .
7484434	0	AT1	125,128	angiotensin_II	100,114	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The relationship between the adrenal tissue renin-angiotensin system , internalization of the type I angiotensin_II receptor -LRB- AT1 -RRB- and angiotensin_II function in the rat adrenal zona_glomerulosa cell .
7493612	0	AT1	26,29	angiotensin_II	118,132	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	LR-B/081|compound|START_ENTITY inhibits|nsubj|LR-B/081 inhibits|dobj|drinking drinking|acl|induced induced|nmod|injection injection|nmod|END_ENTITY	The selective angiotensin AT1 receptor antagonist LR-B/081 potently inhibits drinking induced by central injection of angiotensin_II in rats .
7554134	0	AT1	39,42	angiotensin_II	24,38	AT1	angiotensin II	185	183	Gene	Gene	START_ENTITY|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of cardiac angiotensin_II AT1 receptors in congenital cardiomyopathic hamsters .
7562905	0	AT1	91,94	angiotensin_II	25,39	AT1	angiotensin II	185	183	Gene	Gene	affinity|nmod|START_ENTITY Potent|nmod|affinity Potent|dobj|antagonists antagonists|amod|END_ENTITY	Potent and orally active angiotensin_II receptor antagonists with equal affinity for human AT1 and AT2 subtypes .
7588383	0	AT1	55,58	angiotensin_II	30,44	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Internalisation of the type I angiotensin_II receptor -LRB- AT1 -RRB- and angiotensin_II function in the rat adrenal zona glomerulosa cell .
7686719	0	AT1	55,58	angiotensin_II	40,54	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Immunohistochemical localization of rat angiotensin_II AT1 receptor .
7746328	0	AT1	61,64	angiotensin_II	46,60	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Direct stimulation of Jak/STAT pathway by the angiotensin_II AT1 receptor .
7799397	0	AT1	105,108	angiotensin_II	37,51	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Triazolinone_biphenylsulfonamides|nmod|START_ENTITY Triazolinone_biphenylsulfonamides|nmod|antagonists antagonists|amod|END_ENTITY	Triazolinone_biphenylsulfonamides as angiotensin_II receptor antagonists with high affinity for both the AT1 and AT2 subtypes .
7831501	0	AT1	0,3	angiotensin_II	63,77	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	subtype|nummod|START_ENTITY mediates|nsubj|subtype mediates|dobj|effect effect|nmod|END_ENTITY	AT1 receptor subtype mediates the inhibitory effect of central angiotensin_II on cerebrospinal fluid formation in the rat .
7869841	0	AT1	84,87	angiotensin_II	69,83	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Characterization of the binding of -LSB- 125I -RSB- L-735 ,286 : a new nonpeptide angiotensin_II AT1 receptor radioligand .
7952881	0	AT1	39,42	angiotensin_II	24,38	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	subtype|compound|START_ENTITY subtype|amod|END_ENTITY	Characterization of the angiotensin_II AT1 receptor subtype involved in DNA synthesis in cultured vascular smooth muscle cells .
7980607	0	AT1	55,58	angiotensin_II	154,168	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Internalization|appos|START_ENTITY required|nsubjpass|Internalization required|nmod|END_ENTITY	Internalization of the type I angiotensin_II receptor -LRB- AT1 -RRB- is required for protein kinase C activation but not for inositol_trisphosphate release in the angiotensin_II stimulated rat adrenal zona glomerulosa cell .
7980607	0	AT1	55,58	angiotensin_II	30,44	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Internalization|appos|START_ENTITY Internalization|nmod|receptor receptor|compound|END_ENTITY	Internalization of the type I angiotensin_II receptor -LRB- AT1 -RRB- is required for protein kinase C activation but not for inositol_trisphosphate release in the angiotensin_II stimulated rat adrenal zona glomerulosa cell .
7988654	0	AT1	97,100	angiotensin_II	21,35	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	affinities|nmod|START_ENTITY antagonist|nmod|affinities antagonist|amod|END_ENTITY	EXP597 , a nonpeptide angiotensin_II receptor antagonist with high affinities for the angiotensin AT1 and AT2 receptor subtypes .
8046288	0	AT1	55,58	angiotensin_II	30,44	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Internalisation of the type I angiotensin_II receptor -LRB- AT1 -RRB- and angiotensin_II function in the rat adrenal zona glomerulosa cell .
8064808	0	AT1	101,104	angiotensin_II	62,76	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	affinity|compound|START_ENTITY derivatives|nmod|affinity derivatives|nmod|antagonists antagonists|compound|END_ENTITY	Triazolinone_biphenylsulfonamide derivatives as orally active angiotensin_II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity .
8336821	0	AT1	23,26	angiotensin_II	69,83	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	blockade|nmod|START_ENTITY Effects|nmod|blockade receptors|nsubj|Effects receptors|nmod|response response|amod|END_ENTITY	Effects of blockade of AT1 and AT2 receptors in brain on the central angiotensin_II pressor response in conscious spontaneously hypertensive rats .
8453478	0	AT1	25,28	angiotensin_II	62,76	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|response response|compound|END_ENTITY	Functional role of brain AT1 and AT2 receptors in the central angiotensin_II pressor response .
8491041	0	AT1	26,29	angiotensin_II	63,77	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|response response|amod|END_ENTITY	Functional roles of brain AT1 and AT2 receptors in the central angiotensin_II pressor response in conscious young spontaneously hypertensive rats .
8532590	0	AT1	53,56	angiotensin_II	22,36	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY mediated|nmod|receptor mediated|nsubj|retention retention|nmod|END_ENTITY	Impaired retention by angiotensin_II mediated by the AT1 receptor .
8545239	0	AT1	57,60	angiotensin_II	42,56	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Glycyl-histidyl-lysine interacts with the angiotensin_II AT1 receptor .
8667363	0	AT1	31,34	angiotensin_II	45,59	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Diphenylpropionic_acids as new AT1 selective angiotensin_II antagonists .
8821729	0	AT1	30,33	angiotensin_II	15,29	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Stimulation of angiotensin_II AT1 receptors in rat median eminence increases phosphoinositide hydrolysis .
8904632	0	AT1	101,104	angiotensin_II	39,53	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY reabsorption|nmod|receptor Modulation|acl|reabsorption Modulation|nmod|END_ENTITY	Modulation by locally produced luminal angiotensin_II of proximal tubular sodium reabsorption via an AT1 receptor .
8930186	0	AT1	17,20	angiotensin_II	79,93	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|interaction interaction|nmod|END_ENTITY	Participation of AT1 and AT2 receptors in the differential interaction between angiotensin_II or III and alpha-2 adrenoceptors in the nucleus reticularis gigantocellularis in cardiovascular regulation and antinociception in rats .
8993847	0	AT1	52,55	angiotensin_II	25,39	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nsubj|actions actions|nmod|END_ENTITY	Physiological actions of angiotensin_II mediated by AT1 and AT2 receptors in the brain .
9003008	0	AT1	33,36	angiotensin_II	67,81	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	down-regulated|nsubjpass|START_ENTITY down-regulated|nmod|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9003008	0	AT1	90,93	angiotensin_II	67,81	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY down-regulated|nmod|receptor down-regulated|nmod|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9024263	0	AT1	41,44	angiotensin_II	25,39	AT1	angiotensin II	185	183	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Somatic mutations of the angiotensin_II -LRB- AT1 -RRB- receptor gene are not present in aldosterone-producing adenoma .
9081679	0	AT1	22,25	angiotensin_II	127,141	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY roles|nmod|receptor subtypes|nsubj|roles subtypes|nmod|stimulation stimulation|nmod|END_ENTITY	Differential roles of AT1 and AT2 receptor subtypes in vascular trophic and phenotypic changes in response to stimulation with angiotensin_II .
9101313	0	AT1	108,111	angiotensin_II	58,72	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY antibodies|nmod|receptors using|dobj|antibodies Recognition|acl|using Recognition|nmod|receptors receptors|amod|END_ENTITY	Recognition of tissue - and subtype-specific modulation of angiotensin_II receptors using antibodies against AT1 and AT2 receptors .
9115844	0	AT1	59,62	angiotensin_II	84,98	AT1	angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY Modulation|nmod|receptors Modulation|nmod|END_ENTITY	Modulation of membrane potential and ionic currents by the AT1 and AT2 receptors of angiotensin_II .
9152365	0	AT1	43,46	angiotensin_II	61,75	AT1	angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Losartan , a selective inhibitor of subtype AT1 receptors for angiotensin_II , inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors .
9200674	0	AT1	0,3	angiotensin_II	51,65	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY mediate|nsubj|receptors mediate|dobj|responses responses|acl|induced induced|nmod|END_ENTITY	AT1 receptors mediate pressor responses induced by angiotensin_II in the periaqueductal gray area of rats .
9285642	0	AT1	31,34	angiotensin_II	69,83	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	angiotensin|nummod|START_ENTITY receptors|compound|angiotensin talk|nmod|receptors talk|parataxis|downregulates downregulates|nsubj|END_ENTITY	Cross talk between angiotensin AT1 and alpha 1-adrenergic receptors : angiotensin_II downregulates alpha_1a-adrenergic_receptor subtype mRNA and density in neonatal rat cardiac myocytes .
9287353	0	AT1	132,135	angiotensin_II	117,131	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin_II AT1 receptor .
9413025	0	AT1	104,107	angiotensin_II	37,51	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Dose-dependent inhibitory effects of angiotensin_II on visual responses of the rat superior colliculus : AT1 and AT2 receptor contributions .
9453258	0	AT1	57,60	angiotensin_II	42,56	AT1	angiotensin II	185	183	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Localization and functional properties of angiotensin_II AT1 receptors in the kidney : focus on renomedullary interstitial cells .
9514193	0	AT1	8,11	angiotensin_II	57,71	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY Role|nmod|receptors Role|nmod|END_ENTITY	Role of AT1 and AT2 receptors in the plasma clearance of angiotensin_II .
9537671	0	AT1	96,99	angiotensin_II	4,18	AT1	angiotensin II	185	183	Gene	Gene	distinct|nmod|START_ENTITY distinct|nsubj|site site|compound|END_ENTITY	The angiotensin_II binding site on Mycoplasma_hyorhynis is structurally distinct from mammalian AT1 and AT2 receptors .
9571644	0	AT1	10,13	angiotensin_II	22,36	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Action|nmod|START_ENTITY subtype|nsubj|Action subtype|dobj|receptors receptors|amod|END_ENTITY	Action of AT1 subtype angiotensin_II receptors of the medial preoptic area on gonadotropins and prolactin release .
9655647	0	AT1	63,66	angiotensin_II	47,61	AT1	angiotensin II	185	185	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Molecular and cellular mechanisms of action of angiotensin_II -LRB- AT1 -RRB- receptors in vascular smooth muscle .
9664623	0	AT1	31,34	angiotensin_II	79,93	AT1	angiotensin II	185	183	Gene	Gene	affinity|compound|START_ENTITY Effect|nmod|affinity Effect|nmod|END_ENTITY	Effect of uncoupling agents on AT1 receptor affinity for antagonist analogs of angiotensin_II .
9711980	0	AT1	78,81	angiotensin_II	47,61	AT1	angiotensin II	185	183	Gene	Gene	subtype|compound|START_ENTITY mediated|nmod|subtype mediated|nsubjpass|vasopressin vasopressin|nmod|END_ENTITY	Arginine vasopressin and oxytocin responses to angiotensin_II are mediated by AT1 receptor subtype in normal men .
9730777	0	AT1	102,105	angiotensin_II	34,48	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	influence|nmod|START_ENTITY kidney|dep|influence isolated|dobj|kidney isolated|nsubj|effects effects|nmod|END_ENTITY	Vascular and excretory effects of angiotensin_II in the rat isolated perfused kidney : influence of an AT1 and a nonselective AT receptor antagonist .
9731195	0	AT1	73,76	angiotensin_II	101,115	AT1	angiotensin II	185	183	Gene	Gene	receptor|compound|START_ENTITY associate|nmod|receptor active|nmod|associate active|nmod|END_ENTITY	Janus_kinase_2 -LRB- Jak2 -RRB- must be catalytically active to associate with the AT1 receptor in response to angiotensin_II .
9876309	0	AT1	67,70	angiotensin_II	29,43	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY mediated|nmod|receptors mediated|nsubjpass|hyperglycemia hyperglycemia|acl|induced induced|nmod|END_ENTITY	The hyperglycemia induced by angiotensin_II in rats is mediated by AT1 receptors .
9878793	0	AT1	75,78	angiotensin_II	44,58	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY increases|dobj|expression increases|nsubj|infusion infusion|nmod|END_ENTITY	Chronic intracerebroventricular infusion of angiotensin_II increases brain AT1 receptor expression in young rats .
9932287	0	AT1	62,65	angiotensin_II	36,50	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Immunohistochemical localization of angiotensin_II receptors -LRB- AT1 -RRB- in the heart with anti-peptide antibodies showing a positive chronotropic effect .
9950790	0	AT1	41,44	angiotensin_II	70,84	AT1	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY proliferation|nmod|receptors proliferation|nmod|END_ENTITY	Control of adrenal cell proliferation by AT1 receptors in response to angiotensin_II and low-sodium diet .
22264484	0	AT1	136,139	angiotensin_II_receptor_type_1	104,134	AT1	angiotensin II receptor type 1	81638(Tax:10116)	81638(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and antihypertensive activity of pyrimidin-4 -LRB- 3H -RRB- - one derivatives as losartan analogue for new angiotensin_II_receptor_type_1 -LRB- AT1 -RRB- antagonists .
23845221	0	AT1	119,122	angiotensin_II_receptor_type_1	87,117	AT1	angiotensin II receptor type 1	185	185	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Development of 3D-QSAR CoMSIA models for 5 - -LRB- biphenyl-2-yl -RRB- -1 H-tetrazole derivatives as angiotensin_II_receptor_type_1 -LRB- AT1 -RRB- antagonists .
10738546	0	AT1	89,92	angiotensin_II_subtype_1	63,87	AT1	angiotensin II subtype 1	185	185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of polymorphisms in the promoter of the human angiotensin_II_subtype_1 -LRB- AT1 -RRB- receptor gene .
12897082	0	AT1	63,66	angiotensin_II_subtype_1	37,61	AT1	angiotensin II subtype 1	11607(Tax:10090)	11607(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Cyclosporin increases the density of angiotensin_II_subtype_1 -LRB- AT1 -RRB- receptors in mouse medullary thick ascending limb cells .
15733910	0	AT1	57,60	angiotensin_II_type_1	34,55	AT1	angiotensin II type 1	24180(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	IL-1beta and TNF-alpha upregulate angiotensin_II_type_1 -LRB- AT1 -RRB- receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart .
23273598	0	AT1-R	118,123	angiotensin_II_receptor_type_1	86,116	AT1-R	angiotensin II receptor type 1	185	185	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Correlation between VEGFR-2 receptor kinase domain-containing receptor -LRB- KDR -RRB- mRNA and angiotensin_II_receptor_type_1 -LRB- AT1-R -RRB- mRNA in endometrial_cancer .
9334403	0	AT1A	15,19	Angiotensin_II	0,14	AT1A	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Angiotensin_II AT1A receptor mRNA expression is induced by estrogen-progesterone in dopaminergic neurons of the female rat arcuate nucleus .
16332920	0	AT1A	4,8	angiotensin_II	110,124	AT1A	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY active|nsubj|receptor active|nmod|END_ENTITY	The AT1A receptor `` gain-of-function '' mutant N111S/delta329 is both constitutively active and hyperreactive to angiotensin_II .
25542758	0	AT1A	57,61	angiotensin_II	42,56	AT1A	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Clathrin-dependent internalization of the angiotensin_II AT1A receptor links receptor internalization to COX-2 protein expression in rat aortic vascular smooth muscle cells .
25542758	0	AT1A	57,61	angiotensin_II	42,56	AT1A	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Clathrin-dependent internalization of the angiotensin_II AT1A receptor links receptor internalization to COX-2 protein expression in rat aortic vascular smooth muscle cells .
8484752	0	AT1A	35,39	angiotensin_II	49,63	AT1A	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Comparison of COS cell transfected AT1A and AT1B angiotensin_II receptors and angiotensin_II receptor isoforms in rat tissues using isoelectric focusing .
8584237	0	AT1A	34,38	angiotensin_II	18,32	AT1A	angiotensin II	24180(Tax:10116)	183	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The effect of the angiotensin_II -LRB- AT1A -RRB- receptor stably transfected into human neuroblastoma SH-SY5Y cells on noradrenaline release and changes in intracellular calcium .
8609915	0	AT1A	72,76	angiotensin_II	19,33	AT1A	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	cells|nummod|START_ENTITY mediated|nmod|cells mediated|nsubj|role role|nmod|cAMP cAMP|nmod|END_ENTITY	A role for cAMP in angiotensin_II mediated inhibition of cell growth in AT1A receptor-transfected CHO-K1 cells .
8760087	0	AT1A	14,18	angiotensin_II	28,42	AT1A	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	RNA|compound|START_ENTITY RNA|compound|END_ENTITY	Expression of AT1A and AT1B angiotensin_II receptor messenger RNA in forebrain of 2-wk-old rats .
8925869	0	AT1A	86,90	angiotensin_II	70,84	AT1A	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Evidence against a role for protein kinase C in the regulation of the angiotensin_II -LRB- AT1A -RRB- receptor .
8945996	0	AT1A	91,95	angiotensin_II	11,25	AT1A	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY mediated|nmod|receptors mediated|nsubjpass|Effects Effects|nmod|END_ENTITY	Effects of angiotensin_II on cultured rat renomedullary interstitial cells are mediated by AT1A receptors .
8032651	0	AT1B	50,54	AT1	65,68	AT1B	AT1	81638(Tax:10116)	185	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Comparative pharmacology of recombinant rat AT1A , AT1B and human AT1 receptors expressed by transfected COS-M6 cells .
17617024	0	AT1R	53,57	AT1_receptor	39,51	AT1R	AT1 receptor	185	185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A1166C polymorphism of the angiotensin AT1_receptor -LRB- AT1R -RRB- gene alters endothelial response to statin treatment .
15502641	0	AT1R	99,103	Angiotensin_II	0,14	AT1R	Angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Angiotensin_II mediates acinar cell apoptosis during the development of rat pancreatic_fibrosis by AT1R .
20458733	0	AT1R	47,51	Angiotensin_II	0,14	AT1R	Angiotensin II	185	183	Gene	Gene	signaling|appos|START_ENTITY promotes|nsubj|signaling END_ENTITY|parataxis|promotes	Angiotensin_II / angiotensin_II type I receptor -LRB- AT1R -RRB- signaling promotes MCF-7 breast_cancer cells survival via PI3-kinase/Akt pathway .
22020146	0	AT1R	88,92	Angiotensin_II	0,14	AT1R	Angiotensin II	11610(Tax:10090)	11606(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY pathway|amod|dependent expression|nmod|pathway induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces extracellular_matrix_metalloproteinase_inducer expression via an AT1R dependent pathway in aortic_atherosclerotic_plaque in apolipoprotein_E knockout mice .
25767191	0	AT1R	103,107	Angiotensin_II	0,14	AT1R	Angiotensin II	185	183	Gene	Gene	cells|nmod|START_ENTITY increases|nmod|cells increases|nsubj|END_ENTITY	Angiotensin_II increases matrix_metalloproteinase_2 expression in human aortic smooth muscle cells via AT1R and ERK1/2 .
22362742	0	AT1R	14,18	HuR	38,41	AT1R	HuR	185	1994	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of AT1R expression through HuR by insulin .
20458733	0	AT1R	47,51	angiotensin_II	15,29	AT1R	angiotensin II	185	183	Gene	Gene	signaling|appos|START_ENTITY signaling|compound|receptor receptor|amod|END_ENTITY	Angiotensin_II / angiotensin_II type I receptor -LRB- AT1R -RRB- signaling promotes MCF-7 breast_cancer cells survival via PI3-kinase/Akt pathway .
17710578	0	AT1R	95,99	angiotensin_II_type_1_receptor	63,93	AT1R	angiotensin II type 1 receptor	185	185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Angiotensin-converting enzyme insertion/deletion -LRB- ACE I/D -RRB- and angiotensin_II_type_1_receptor -LRB- AT1R -RRB- gene polymorphism and its association with preeclampsia in Chinese women .
19162259	0	AT1R	96,100	angiotensin_II_type_1_receptor	64,94	AT1R	angiotensin II type 1 receptor	185	185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Angiotensin-converting enzyme -LRB- ACE -RRB- , angiotensinogen -LRB- AGT -RRB- , and angiotensin_II_type_1_receptor -LRB- AT1R -RRB- gene polymorphisms in generalized aggressive periodontitis .
25767191	0	AT1R	103,107	matrix_metalloproteinase_2	25,51	AT1R	matrix metalloproteinase 2	185	4313	Gene	Gene	cells|nmod|START_ENTITY increases|nmod|cells increases|dobj|expression expression|amod|END_ENTITY	Angiotensin_II increases matrix_metalloproteinase_2 expression in human aortic smooth muscle cells via AT1R and ERK1/2 .
18603592	0	AT1R	15,19	p100	0,4	SND1	p100	27044	27044	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	p100 increases AT1R expression through interaction with AT1R 3 ' - UTR .
17617024	0	AT1_receptor	39,51	AT1R	53,57	AT1 receptor	AT1R	185	185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A1166C polymorphism of the angiotensin AT1_receptor -LRB- AT1R -RRB- gene alters endothelial response to statin treatment .
16198631	0	AT1_receptor	15,27	Angiotensin_II	0,14	AT1 receptor	Angiotensin II	185	183	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	Angiotensin_II AT1_receptor density on blood platelets predicts early left ventricular remodelling in non-reperfused acute myocardial_infarction in humans .
22844079	0	AT1_receptor	38,50	Angiotensin_II	0,14	AT1 receptor	Angiotensin II	11610(Tax:10090)	11606(Tax:10090)	Gene	Gene	Nox4|compound|START_ENTITY damage|nmod|Nox4 induces|dobj|damage induces|nsubj|END_ENTITY	Angiotensin_II induces DNA damage via AT1_receptor and NADPH oxidase isoform Nox4 .
24218433	0	AT1_receptor	43,55	GRK4	8,12	AT1 receptor	GRK4	11610(Tax:10090)	14772(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of GRK4 in the regulation of arterial AT1_receptor in hypertension .
25122005	0	AT1_receptor	51,63	PPARy	31,36	AT1 receptor	PPARy	11610(Tax:10090)	5468	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Role of vascular smooth muscle PPARy in regulating AT1_receptor signaling and angiotensin II-dependent hypertension .
10222259	0	AT1_receptor	78,90	angiotensin_II	21,35	AT1 receptor	angiotensin II	11610(Tax:10090)	11606(Tax:10090)	Gene	Gene	upregulation|nmod|START_ENTITY exaggerated|nmod|upregulation exaggerated|nsubj|response response|nmod|END_ENTITY	Vascular response to angiotensin_II is exaggerated through an upregulation of AT1_receptor in AT2 knockout mice .
15117826	0	AT1_receptor	114,126	angiotensin_II	99,113	AT1 receptor	angiotensin II	11610(Tax:10090)	11606(Tax:10090)	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Chronic production of angiotensin_IV in the brain leads to hypertension that is reversible with an angiotensin_II AT1_receptor antagonist .
16141358	0	AT1_receptor	12,24	angiotensin_II	94,108	AT1 receptor	angiotensin II	185	183	Gene	Gene	pathways|nsubj|START_ENTITY pathways|xcomp|mediating mediating|dobj|actions actions|nmod|END_ENTITY	Pleiotropic AT1_receptor signaling pathways mediating physiological and pathogenic actions of angiotensin_II .
8158154	0	AT1_receptor	42,54	angiotensin_II	117,131	AT1 receptor	angiotensin II	11610(Tax:10090)	24179(Tax:10116)	Gene	Gene	oligonucleotides|amod|START_ENTITY administration|nmod|oligonucleotides inhibits|nsubj|administration inhibits|dobj|actions actions|nmod|END_ENTITY	Intracerebroventricular administration of AT1_receptor antisense oligonucleotides inhibits the behavioral actions of angiotensin_II .
21822148	0	AT1_receptor	6,18	toll-like_receptor_4	68,88	AT1 receptor	toll-like receptor 4	11610(Tax:10090)	21898(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Brain AT1_receptor activates the sympathetic nervous system through toll-like_receptor_4 in mice with heart_failure .
14517903	0	AT1a	102,106	angiotensin_II	78,92	AT1a	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|amod|angiotensin_II angiotensin_II|nmod|fragment fragment|nmod|END_ENTITY	Interaction of angiotensin_II with the C-terminal 300-320 fragment of the rat angiotensin_II receptor AT1a monitored by NMR .
24740791	0	AT1a	14,18	angiotensin_II	47,61	AT1a	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Mechanisms of AT1a receptor-mediated uptake of angiotensin_II by proximal tubule cells : a novel role of the multiligand endocytic receptor megalin .
23946289	0	AT2	15,18	AT1	50,53	AT2	AT1	24182(Tax:10116)	24180(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY attenuates|nsubj|activation attenuates|dobj|increases increases|nummod|END_ENTITY	Angiotensin_II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin : a multiphoton microscopy study .
15551065	0	AT2	54,57	Angiotensin_II	0,14	AT2	Angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	mechanism|compound|START_ENTITY blocks|nmod|mechanism blocks|nsubj|END_ENTITY	Angiotensin_II blocks memory consolidation through an AT2 receptor-dependent mechanism .
16220978	0	AT2	90,93	Angiotensin_II	0,14	AT2	Angiotensin II	186	183	Gene	Gene	affinity|compound|START_ENTITY containing|nmod|affinity pseudopeptides|xcomp|containing pseudopeptides|nsubj|END_ENTITY	Angiotensin_II pseudopeptides containing 1,3,5-trisubstituted _ benzene scaffolds with high AT2 receptor affinity .
1908781	0	AT2	15,18	Angiotensin_II	0,14	AT2	Angiotensin II	186	183	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Angiotensin_II AT2 receptors do not interact with guanine_nucleotide binding proteins .
19129693	0	AT2	65,68	Angiotensin_II	0,14	AT2	Angiotensin II	186	183	Gene	Gene	receptors|nummod|START_ENTITY role|nmod|receptors upregulates|parataxis|role upregulates|nsubj|END_ENTITY	Angiotensin_II upregulates RAGE expression on podocytes : role of AT2 receptors .
22776205	0	AT2	76,79	Angiotensin_II	0,14	AT2	Angiotensin II	186	183	Gene	Gene	receptor|compound|START_ENTITY induces|nmod|receptor induces|nsubj|END_ENTITY	Angiotensin_II induces apoptosis in intestinal epithelial cells through the AT2 receptor , GATA-6 and the Bax pathway .
23573410	0	AT2	52,55	Angiotensin_II	56,70	AT2	Angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	Subtypes|compound|START_ENTITY Subtypes|compound|END_ENTITY	Immunohistochemical Localization of AT1a , AT1b , and AT2 Angiotensin_II Receptor Subtypes in the Rat Adrenal , Pituitary , and Brain with a Perspective Commentary .
23946289	0	AT2	15,18	Angiotensin_II	0,14	AT2	Angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Angiotensin_II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin : a multiphoton microscopy study .
7972928	0	AT2	15,18	Angiotensin_II	0,14	AT2	Angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	increases|compound|START_ENTITY increases|compound|END_ENTITY	Angiotensin_II AT2 receptor stimulation increases cerebrovascular resistance during hemorrhagic hypotension in rats .
9453004	0	AT2	98,101	Angiotensin_II	0,14	AT2	Angiotensin II	186	183	Gene	Gene	receptor|compound|START_ENTITY inhibits|nmod|receptor inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits growth of cultured embryonic renomedullary interstitial cells through the AT2 receptor .
9473667	0	AT2	97,100	Angiotensin_II	0,14	AT2	Angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY role|nmod|receptor proteins|dep|role influence|dobj|proteins influence|nsubj|END_ENTITY	Angiotensin_II and NGF differentially influence microtubule proteins in PC12W cells : role of the AT2 receptor .
15808917	0	AT2	79,82	NHE6	104,108	AT2	NHE6	20726(Tax:10090)	236794(Tax:10090)	Gene	Gene	formation|nmod|START_ENTITY formation|dep|END_ENTITY	Ligand-dependent complex formation between the Angiotensin_II receptor subtype AT2 and Na + / H + exchanger NHE6 in mammalian cells .
10222259	0	AT2	94,97	angiotensin_II	21,35	AT2	angiotensin II	20726(Tax:10090)	11606(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY AT1_receptor|nmod|mice upregulation|nmod|AT1_receptor exaggerated|nmod|upregulation exaggerated|nsubj|response response|nmod|END_ENTITY	Vascular response to angiotensin_II is exaggerated through an upregulation of AT1_receptor in AT2 knockout mice .
10652498	0	AT2	44,47	angiotensin_II	29,43	AT2	angiotensin II	186	186	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Signal transduction from the angiotensin_II AT2 receptor .
11384773	0	AT2	29,32	angiotensin_II	118,132	AT2	angiotensin II	186	183	Gene	Gene	receptors|nummod|START_ENTITY down-regulation|nmod|receptors given|nsubj|down-regulation given|dobj|infusions infusions|nmod|END_ENTITY	Selective down-regulation of AT2 receptors in uterine arteries from pregnant ewes given 24-h intravenous infusions of angiotensin_II .
1330640	0	AT2	61,64	angiotensin_II	45,59	AT2	angiotensin II	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Characterization of biochemical responses of angiotensin_II -LRB- AT2 -RRB- binding sites in the rat pheochromocytoma PC12W cells .
1437716	0	AT2	29,32	angiotensin_II	14,28	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of angiotensin_II AT2 receptors in the rat skin during experimental wound healing .
14530222	0	AT2	34,37	angiotensin_II	19,33	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Functional role of angiotensin_II AT2 receptor in modulation of AT1 receptor-mediated contraction in rat uterine artery : involvement of bradykinin and nitric_oxide .
15485557	0	AT2	14,17	angiotensin_II	49,63	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	properties|nummod|START_ENTITY properties|nmod|END_ENTITY	Synthesis and AT2 receptor-binding properties of angiotensin_II analogues .
1639112	0	AT2	4,7	angiotensin_II	23,37	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	subtype|compound|START_ENTITY subtype|nmod|receptors receptors|amod|END_ENTITY	The AT2 subtype of the angiotensin_II receptors has differential sensitivity to dithiothreitol in specific brain nuclei of young rats .
17068200	0	AT2	130,133	angiotensin_II	50,64	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	protein|nummod|START_ENTITY interaction|nmod|protein cascade|nmod|interaction differentiation|dep|cascade differentiation|nmod|type type|compound|END_ENTITY	Angiotensin_II-induced neural differentiation via angiotensin_II type 2 -LRB- AT2 -RRB- receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src_homology_2_domain-containing_protein-tyrosine_phosphatase_1 .
17068200	0	AT2	73,76	angiotensin_II	50,64	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	differentiation|appos|START_ENTITY differentiation|nmod|type type|compound|END_ENTITY	Angiotensin_II-induced neural differentiation via angiotensin_II type 2 -LRB- AT2 -RRB- receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src_homology_2_domain-containing_protein-tyrosine_phosphatase_1 .
17125268	0	AT2	25,28	angiotensin_II	10,24	AT2	angiotensin II	186	183	Gene	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	Selective angiotensin_II AT2 receptor agonists : arylbenzylimidazole structure-activity relationships .
18511032	0	AT2	139,142	angiotensin_II	11,25	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY angiotensin_III|nsubj|receptor Effects|parataxis|angiotensin_III Effects|nmod|END_ENTITY	Effects of angiotensin_II and its metabolites in the rat coronary vascular bed : is angiotensin_III the preferred ligand of the angiotensin AT2 receptor ?
1887916	0	AT2	20,23	angiotensin_II	24,38	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|amod|END_ENTITY	Characterization of AT2 angiotensin_II receptors in rat anterior cerebral arteries .
19353416	0	AT2	98,101	angiotensin_II	77,91	AT2	angiotensin II	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	AT1|dep|START_ENTITY END_ENTITY|appos|AT1	Increased perfusion pressure enhances the expression of endothelin -LRB- ETB -RRB- and angiotensin_II -LRB- AT1 , AT2 -RRB- receptors in rat mesenteric artery smooth muscle cells .
25170617	0	AT2	32,35	angiotensin_II	84,98	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY ERK1/2-eNOS|nmod|receptors Upregulation|nmod|ERK1/2-eNOS decreases|nsubj|Upregulation decreases|nmod|END_ENTITY	Upregulation of ERK1/2-eNOS via AT2 receptors decreases the contractile response to angiotensin_II in resistance mesenteric arteries from obese rats .
7507323	0	AT2	113,116	angiotensin_II	43,57	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY tyrosine|nmod|receptor tyrosine|nmod|END_ENTITY	Protein tyrosine phosphatase inhibition by angiotensin_II in rat pheochromocytoma cells through type 2 receptor , AT2 .
8143746	0	AT2	100,103	angiotensin_II	104,118	AT2	angiotensin II	186	183	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Characterization of a membrane glycoprotein having pharmacological and biochemical properties of an AT2 angiotensin_II receptor from human myometrium .
8258820	0	AT2	85,88	angiotensin_II	55,69	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	site|compound|START_ENTITY binding|nmod|site series|amod|binding series|nmod|inhibitors inhibitors|nmod|END_ENTITY	A novel series of selective , non-peptide inhibitors of angiotensin_II binding to the AT2 site .
8311944	0	AT2	27,30	angiotensin_II	62,76	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	The effect of the putative AT2 agonist , p-aminophenylalanine6 angiotensin_II , on thirst and sodium_appetite in rats .
8453029	0	AT2	41,44	angiotensin_II	26,40	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Characterization of brain angiotensin_II AT2 receptor subtype using -LSB- 125I -RSB- CGP_42112A .
8469774	0	AT2	40,43	angiotensin_II	24,38	AT2	angiotensin II	186	186	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulated expression of angiotensin_II -LRB- AT2 -RRB- binding sites in R3T3 cells .
9521484	0	AT2	8,11	angiotensin_II	79,93	AT2	angiotensin II	24182(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|nmod|events events|nmod|microinjection microinjection|nmod|END_ENTITY	Role of AT2 receptors in the cardiovascular events following microinjection of angiotensin_II into the superior colliculus of anaesthetised rats .
9570482	0	AT2	80,83	angiotensin_II	46,60	AT2	angiotensin II	186	183	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	N - and C-terminal structure-activity study of angiotensin_II on the angiotensin AT2 receptor .
9773120	0	AT2	14,17	angiotensin_II	31,45	AT2	angiotensin II	186	183	Gene	Gene	receptors|nummod|START_ENTITY receptors|nmod|END_ENTITY	-LSB- Functions of AT2 receptors of angiotensin_II -RSB- .
9826555	0	AT2	64,67	angiotensin_II	81,95	AT2	angiotensin II	186	183	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Modulation of the vascular smooth muscle angiotensin subtype 2 -LRB- AT2 -RRB- receptor by angiotensin_II .
15034006	0	AT2	84,87	angiotensin_II_receptor_subtype_2	49,82	AT2	angiotensin II receptor subtype 2	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical and mRNA localization of the angiotensin_II_receptor_subtype_2 -LRB- AT2 -RRB- in follicular granulosa cells of the rat ovary .
12969123	0	AT2	40,43	angiotensin_type_2	20,38	AT2	angiotensin type 2	186	186	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Renal expression of angiotensin_type_2 -LRB- AT2 -RRB- receptors during kidney_damage .
7859090	0	AT2	51,54	angiotensin_type_2	31,49	AT2	angiotensin type 2	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Immunohistochemical mapping of angiotensin_type_2 -LRB- AT2 -RRB- receptors in rat brain .
17884764	0	AT2	9,12	tumor_necrosis_factor_alpha	49,76	AT2	tumor necrosis factor alpha	24182(Tax:10116)	24835(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|nmod|END_ENTITY	-LSB- Role of AT2 receptors on angiotensin II-induced tumor_necrosis_factor_alpha and interleukin_1_beta secretion in adult rat cardiac fibroblasts -RSB- .
25953323	0	AT2R	74,78	angiotensin_II_type_2_receptor	42,72	AT2R	angiotensin II type 2 receptor	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	b-Pro7Ang III is a novel highly selective angiotensin_II_type_2_receptor -LRB- AT2R -RRB- agonist , which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats .
25953323	0	AT2R	74,78	angiotensin_II_type_2_receptor	42,72	AT2R	angiotensin II type 2 receptor	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	b-Pro7Ang III is a novel highly selective angiotensin_II_type_2_receptor -LRB- AT2R -RRB- agonist , which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats .
26186568	0	AT2R	74,78	angiotensin_II_type_2_receptor	42,72	AT2R	angiotensin II type 2 receptor	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	b-Pro7Ang III is a novel highly selective angiotensin_II_type_2_receptor -LRB- AT2R -RRB- agonist , which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats .
15153556	0	AT2_receptor	72,84	Angiotensin_II	0,14	AT2 receptor	Angiotensin II	11609(Tax:10090)	11606(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY increases|nmod|cells increases|nsubj|END_ENTITY	Angiotensin_II increases Pax-2 expression in fetal kidney cells via the AT2_receptor .
20693103	0	AT2_receptor	50,62	PARP-1	100,106	AT2 receptor	PARP-1	11609(Tax:10090)	11545(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY mediated|nsubjpass|downregulation mediated|nmod|END_ENTITY	Ethanol-induced downregulation of the angiotensin AT2_receptor in murine fibroblasts is mediated by PARP-1 .
7935513	0	AT3	70,73	antithrombin	51,63	AT3	antithrombin	462	462	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Trinucleotide repeat polymorphism within the human antithrombin gene -LRB- AT3 -RRB- : allele frequency data for three population groups .
1505975	0	AT3	54,57	antithrombin_III	36,52	AT3	antithrombin III	462	462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	De novo splice site mutation in the antithrombin_III -LRB- AT3 -RRB- gene causing recurrent venous_thrombosis : demonstration of exon skipping by ectopic transcript analysis .
7959685	0	AT3	56,59	antithrombin_III	38,54	AT3	antithrombin III	462	462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Three novel missense mutations in the antithrombin_III -LRB- AT3 -RRB- gene causing recurrent venous_thrombosis .
16919623	0	AT4_receptor	12,24	cystinyl_aminopeptidase	49,72	AT4 receptor	cystinyl aminopeptidase	4012	4012	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Angiotensin AT4_receptor ligand interaction with cystinyl_aminopeptidase and aminopeptidase_N : -LSB- 125I -RSB- Angiotensin_IV only binds to the cystinyl_aminopeptidase apo-enzyme .
22245785	0	ATAD-3	36,42	MICS-1	0,6	ATAD-3	MICS-1	174590(Tax:6239)	179475(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. _ elegans .
24552534	0	ATAD2	36,41	miR-372	0,7	ATAD2	miR-372	29028	442917	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular_carcinoma proliferation and metastasis .
20351179	0	ATAD3A	150,156	S100B	42,47	ATAD3A	S100B	55210	6285	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A .
22542587	0	ATAD3A	60,66	S100B	89,94	ATAD3A	S100B	55210	6285	Gene	Gene	production|nmod|START_ENTITY production|appos|target target|nmod|END_ENTITY	Yeast-based production and purification of HIS-tagged human ATAD3A , A specific target of S100B .
26722215	0	ATAD5	47,52	E2F1	72,76	ATAD5	E2F1	79915	1869	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Hepatitis_B_Virus X Protein Upregulates hELG1 / ATAD5 Expression through E2F1 in Hepatocellular_Carcinoma .
26722215	0	ATAD5	47,52	hELG1	40,45	ATAD5	hELG1	79915	79915	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|dep|Expression	Hepatitis_B_Virus X Protein Upregulates hELG1 / ATAD5 Expression through E2F1 in Hepatocellular_Carcinoma .
9153189	0	ATAR	0,4	TRAF2	76,81	ATAR	TRAF2	8764	7186	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	ATAR , a novel tumor necrosis factor receptor family member , signals through TRAF2 and TRAF5 .
17190598	0	ATAXIN-1	0,8	Capicua	38,45	ATAXIN-1	Capicua	6310	53560(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1_neuropathology .
15905073	0	ATB0	43,47	SLC6A14	51,58	ATB0	SLC6A14	6510	11254	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of the amino_acid transporter ATB0 , + -LRB- SLC6A14 -RRB- in colorectal_cancer and metastasis in humans .
11314020	0	ATBF1	70,75	Alpha-fetoprotein	0,17	ATBF1	Alpha-fetoprotein	463	174	Gene	Gene	lacks|dobj|START_ENTITY lacks|nsubj|gastric_cancer gastric_cancer|amod|END_ENTITY	Alpha-fetoprotein producing gastric_cancer lacks transcription factor ATBF1 .
8995484	0	ATBF1	18,23	Atbf1	51,56	ATBF1	Atbf1	11906(Tax:10090)	11906(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the ATBF1 transcription factor gene -LRB- Atbf1 -RRB- to mouse chromosome band 8E1 by in situ hybridization .
11786962	0	ATBF1	60,65	alpha-fetoprotein	18,35	ATBF1	alpha-fetoprotein	463	174	Gene	Gene	factor|compound|START_ENTITY Regulation|nmod|factor Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of the alpha-fetoprotein gene by the isoforms of ATBF1 transcription factor in human hepatoma .
1719379	0	ATBF1	52,57	alpha-fetoprotein	8,25	ATBF1	alpha-fetoprotein	463	174	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	A human alpha-fetoprotein enhancer-binding protein , ATBF1 , contains four homeodomains and seventeen zinc fingers .
7507206	0	ATBF1	0,5	alpha-fetoprotein	108,125	ATBF1	alpha-fetoprotein	463	174	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|AT-rich_elements AT-rich_elements|nmod|gene gene|amod|END_ENTITY	ATBF1 , a multiple-homeodomain zinc finger protein , selectively down-regulates AT-rich_elements of the human alpha-fetoprotein gene .
14978340	0	ATBF1	103,108	p21	127,130	ATBF1	p21	463	1026	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Susceptibility to killer T cells of gastric_cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21 -LRB- Waf1/Cip1 -RRB- promoter .
20368352	0	ATDC	4,8	TRIM29	10,16	ATDC	TRIM29	23650	23650	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The ATDC -LRB- TRIM29 -RRB- protein binds p53 and antagonizes p53-mediated functions .
20947501	0	ATDC	61,65	TRIM29	67,73	ATDC	TRIM29	23650	23650	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Histone_deacetylase_9 -LRB- HDAC9 -RRB- regulates the functions of the ATDC -LRB- TRIM29 -RRB- protein .
11642609	0	ATF-1	14,19	CREB	20,24	ATF-1	CREB	466	1385	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting the ATF-1 / CREB transcription factors by single chain Fv fragment in human melanoma : potential modality for cancer therapy .
15491278	0	ATF-1	18,23	NOX1	40,44	ATF-1	NOX1	315305(Tax:10116)	114243(Tax:10116)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Essential role of ATF-1 in induction of NOX1 , a catalytic subunit of NADPH oxidase : involvement of mitochondrial respiratory chain .
15531295	0	ATF-2	82,87	CREB	76,80	ATF-2	CREB	11909(Tax:10090)	12912(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Piperine is a potent inhibitor of nuclear factor-kappaB -LRB- NF-kappaB -RRB- , c-Fos , CREB , ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells .
18386196	0	ATF-2	24,29	CREB	31,35	ATF-2	CREB	81647(Tax:10116)	81646(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of activated ATF-2 , CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry .
8407959	0	ATF-2	138,143	CREB	194,198	ATF-2	CREB	1386	1385	Gene	Gene	binding|dep|START_ENTITY response|amod|binding response|appos|END_ENTITY	Transactivation by the human T-cell_leukemia virus Tax protein is mediated through enhanced binding of activating_transcription_factor-2 -LRB- ATF-2 -RRB- ATF-2 response and cAMP element-binding protein -LRB- CREB -RRB- .
8407959	0	ATF-2	145,150	CREB	194,198	ATF-2	CREB	1386	1385	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Transactivation by the human T-cell_leukemia virus Tax protein is mediated through enhanced binding of activating_transcription_factor-2 -LRB- ATF-2 -RRB- ATF-2 response and cAMP element-binding protein -LRB- CREB -RRB- .
8479741	0	ATF-2	125,130	CREB	115,119	ATF-2	CREB	1386	1385	Gene	Gene	blocks|compound|START_ENTITY END_ENTITY|nmod|blocks	Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2 : interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation .
8479741	0	ATF-2	125,130	CREB	84,88	ATF-2	CREB	1386	1385	Gene	Gene	blocks|compound|START_ENTITY CREB|nmod|blocks interaction|nmod|CREB interactions|dep|interaction interactions|nmod|END_ENTITY	Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2 : interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation .
17031850	0	ATF-2	145,150	CREB-1	151,157	ATF-2	CREB-1	1386	1385	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Differential regulation of cyclooxygenase-2 and inducible nitric_oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2 / CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade .
27094031	0	ATF-2	77,82	CREB-1	83,89	ATF-2	CREB-1	1386	1385	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2 / CREB-1 phosphorylation .
16405968	0	ATF-2	29,34	Cyclin_D1	0,9	ATF-2	Cyclin D1	11909(Tax:10090)	12443(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Cyclin_D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration .
11231009	0	ATF-2	75,80	Jun_dimerization_protein_2	24,50	ATF-2	Jun dimerization protein 2	11909(Tax:10090)	81703(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of mouse Jun_dimerization_protein_2 as a novel repressor of ATF-2 .
17054722	0	ATF-2	19,24	Sin1	0,4	ATF-2	Sin1	1386	79109	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway .
12878171	0	ATF-2	0,5	Smad3	22,27	ATF-2	Smad3	395727(Tax:9031)	395132(Tax:9031)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation .
15371457	0	ATF-2	21,26	Syndecan-4	0,10	ATF-2	Syndecan-4	1386	6385	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent manner .
15531295	0	ATF-2	82,87	c-Fos	69,74	ATF-2	c-Fos	11909(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Piperine is a potent inhibitor of nuclear factor-kappaB -LRB- NF-kappaB -RRB- , c-Fos , CREB , ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells .
17700520	0	ATF-2	0,5	p53	81,84	ATF-2	p53	11909(Tax:10090)	22060(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	ATF-2 controls transcription of Maspin and GADD45_alpha genes independently from p53 to suppress mammary_tumors .
18194435	0	ATF-3	14,19	B-Raf	34,39	ATF-3	B-Raf	467	673	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074 .
19582787	0	ATF-3	47,52	Transforming_growth_factor-beta1	0,32	ATF-3	Transforming growth factor-beta1	467	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Transforming_growth_factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast_cancer cells .
19582787	0	ATF-3	75,80	Transforming_growth_factor-beta1	0,32	ATF-3	Transforming growth factor-beta1	467	7040	Gene	Gene	genes|compound|START_ENTITY regulation|nmod|genes regulation|amod|END_ENTITY	Transforming_growth_factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast_cancer cells .
24973221	0	ATF-3	137,142	activating_transcription_factor-3	102,135	ATF-3	activating transcription factor-3	11910(Tax:10090)	11910(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Metformin suppresses lipopolysaccharide -LRB- LPS -RRB- - induced inflammatory response in murine macrophages via activating_transcription_factor-3 -LRB- ATF-3 -RRB- induction .
11278933	0	ATF-7	0,5	protein-tyrosine_phosphatase	54,82	ATF-7	protein-tyrosine phosphatase	11016	26191	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ATF-7 , a novel bZIP protein , interacts with the PRL-1 protein-tyrosine_phosphatase .
17565989	0	ATF1	21,25	PIAS3	0,5	ATF1	PIAS3	466	10401	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element .
20740050	0	ATF2	69,73	ATM	50,53	ATF2	ATM	11909(Tax:10090)	11920(Tax:10090)	Gene	Gene	Mice|compound|START_ENTITY Mice|compound|END_ENTITY	Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice .
12663670	0	ATF2	146,150	JNK	45,48	ATF2	JNK	1386	5599	Gene	Gene	activating_transcription_factor_2|appos|START_ENTITY resistance|nmod|activating_transcription_factor_2 promote|dobj|resistance serves|xcomp|promote serves|nsubj|activation activation|nmod|kinase kinase|appos|END_ENTITY	The activation of c-Jun NH2-terminal kinase -LRB- JNK -RRB- by DNA-damaging agents serves to promote drug resistance via activating_transcription_factor_2 -LRB- ATF2 -RRB- - dependent enhanced DNA repair .
21384452	0	ATF2	79,83	JNK	17,20	ATF2	JNK	1386	5599	Gene	Gene	JNK|nummod|START_ENTITY interaction|nmod|JNK modulates|nmod|interaction modulates|dobj|activity activity|compound|END_ENTITY	GST pi modulates JNK activity through a direct interaction with JNK substrate , ATF2 .
7824938	0	ATF2	21,25	JNK	44,47	ATF2	JNK	1386	5599	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Transcription factor ATF2 regulation by the JNK signal transduction pathway .
21203491	0	ATF2	11,15	MITF	30,34	ATF2	MITF	11909(Tax:10090)	17342(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for ATF2 in regulating MITF and melanoma development .
18227516	0	ATF2	54,58	activating_transcription_factor_2	19,52	ATF2	activating transcription factor 2	11909(Tax:10090)	11909(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Suppressor role of activating_transcription_factor_2 -LRB- ATF2 -RRB- in skin_cancer .
9488727	0	ATF2	50,54	activating_transcription_factor_2	15,48	ATF2	activating transcription factor 2	1386	1386	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of activating_transcription_factor_2 -LRB- ATF2 -RRB- with the ubiquitin-conjugating enzyme hUBC9 .
9488727	0	ATF2	50,54	hUBC9	94,99	ATF2	hUBC9	1386	7329	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of activating_transcription_factor_2 -LRB- ATF2 -RRB- with the ubiquitin-conjugating enzyme hUBC9 .
21901137	0	ATF2	26,30	miR-26b	34,41	ATF2	miR-26b	1386	407017	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Coordinated regulation of ATF2 by miR-26b in y-irradiated lung_cancer cells .
17699753	0	ATF2	40,44	p38	23,26	ATF2	p38	11909(Tax:10090)	26416(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells .
20581861	0	ATF3	74,78	Activating_transcription_factor_2	0,33	ATF3	Activating transcription factor 2	467	1386	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Activating_transcription_factor_2 -LRB- ATF2 -RRB- controls tolfenamic_acid-induced ATF3 expression via MAP kinase pathways .
10673325	0	ATF3	35,39	Activating_transcription_factor_3	0,33	ATF3	Activating transcription factor 3	25389(Tax:10116)	25389(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Activating_transcription_factor_3 -LRB- ATF3 -RRB- induction by axotomy in sensory and motoneurons : A novel neuronal marker of nerve_injury .
20002170	0	ATF3	35,39	Activating_transcription_factor_3	0,33	ATF3	Activating transcription factor 3	467	467	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Activating_transcription_factor_3 -LRB- ATF3 -RRB- expression is increased in erythema_multiforme and is regulated by IFN-gamma in human keratinocytes .
20423458	0	ATF3	62,66	AdipoR2	0,7	ATF3	AdipoR2	467	79602	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells .
17764926	0	ATF3	77,81	EGR-1	86,91	ATF3	EGR-1	467	1958	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Green tea catechin _ -LRB- - -RRB- - epicatechin_gallate induces tumour suppressor protein ATF3 via EGR-1 activation .
22230687	0	ATF3	74,78	EGR-1	58,63	ATF3	EGR-1	467	1958	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|amod|dependent dependent|amod|END_ENTITY	Patulin induces colorectal_cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation .
18719024	0	ATF3	44,48	Egr-1	81,86	ATF3	Egr-1	467	1958	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of the transcriptional repressor ATF3 in gonadotrophs is regulated by Egr-1 , CREB , and ATF2 after gonadotropin-releasing_hormone_receptor stimulation .
18057093	0	ATF3	31,35	IRS2	18,22	ATF3	IRS2	25389(Tax:10116)	29376(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	The repression of IRS2 gene by ATF3 , a stress-inducible gene , contributes to pancreatic beta-cell apoptosis .
21821004	0	ATF3	0,4	PDX-1	15,20	ATF3	PDX-1	11910(Tax:10090)	18609(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	ATF3 represses PDX-1 expression in pancreatic b-cells .
25096061	0	ATF3	110,114	SPTBN1	39,45	ATF3	SPTBN1	467	6711	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2 .
25096061	0	ATF3	110,114	STAT3	30,35	ATF3	STAT3	467	6774	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2 .
26709509	0	ATF3	46,50	TGF-b	59,64	ATF3	TGF-b	467	7040	Gene	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-b Receptor Pathway in Human Aortic Endothelial Cells .
12718878	0	ATF3	98,102	TGFbeta	16,23	ATF3	TGFbeta	467	7040	Gene	Gene	response|dep|START_ENTITY response|compound|END_ENTITY	A self-enabling TGFbeta response coupled to stress signaling : Smad engages stress response factor ATF3 for Id1 repression in epithelial cells .
26133317	0	ATF3	0,4	THP-1	71,76	ATF3	THP-1	467	2736	Gene	Gene	Formation|compound|START_ENTITY Formation|nmod|END_ENTITY	ATF3 Inhibits Tenascin-C-induced Foam Cell Formation in LPS-Stimulated THP-1 Macrophages by Suppressing TLR-4 .
25865756	0	ATF3	27,31	Tip60	72,77	ATF3	Tip60	467	10524	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60 .
16688168	0	ATF3	36,40	Toll-like_receptor_4	68,88	ATF3	Toll-like receptor 4	11910(Tax:10090)	21898(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Systems biology approaches identify ATF3 as a negative regulator of Toll-like_receptor_4 .
16019731	0	ATF3	48,52	activating_transcription_factor_3	13,46	ATF3	activating transcription factor 3	25389(Tax:10116)	25389(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of activating_transcription_factor_3 -LRB- ATF3 -RRB- by peripheral_nerve_compression .
18377912	0	ATF3	78,82	activating_transcription_factor_3	43,76	ATF3	activating transcription factor 3	515266(Tax:9913)	515266(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Acute hypoxia to endothelial cells induces activating_transcription_factor_3 -LRB- ATF3 -RRB- expression that is mediated via nitric_oxide .
24939851	0	ATF3	43,47	activating_transcription_factor_3	8,41	ATF3	activating transcription factor 3	467	467	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of activating_transcription_factor_3 -LRB- ATF3 -RRB- in endoplasmic reticulum -LRB- ER -RRB- stress-induced sensitization of p53-deficient human colon_cancer cells to tumor necrosis factor -LRB- TNF -RRB- - related apoptosis-inducing ligand -LRB- TRAIL -RRB- - mediated apoptosis through up-regulation of death_receptor_5 -LRB- DR5 -RRB- by zerumbone and celecoxib .
20696134	0	ATF3	0,4	adiponectin_receptor_1	26,48	ATF3	adiponectin receptor 1	467	51094	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	ATF3 negatively regulates adiponectin_receptor_1 expression .
25848832	0	ATF3	17,21	c-Jun_N-Terminal_Kinase	35,58	ATF3	c-Jun N-Terminal Kinase	25389(Tax:10116)	116554(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Pathways Pathways|amod|END_ENTITY	Heroin Activates ATF3 and CytC via c-Jun_N-Terminal_Kinase Pathways to Mediate Neuronal Apoptosis .
25752455	0	ATF3	15,19	iNOS	50,54	ATF3	iNOS	11910(Tax:10090)	18126(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of ATF3 in the negative regulation of iNOS expression and NO production in activated macrophages .
17347301	0	ATF4	0,4	C/EBPepsilon	86,98	ATF4	C/EBPepsilon	468	1053	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha .
24418675	0	ATF4	14,18	COX-2	61,66	ATF4	COX-2	11911(Tax:10090)	17709(Tax:10090)	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2 / PGE2 dependent signaling pathway .
24041694	0	ATF4	99,103	FGF21	78,83	ATF4	FGF21	468	26291	Gene	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|nummod|END_ENTITY	Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation .
24900988	0	ATF4	0,4	FGF21	38,43	ATF4	FGF21	468	26291	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	ATF4 - and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress .
25914608	0	ATF4	0,4	MCP-1	29,34	ATF4	MCP-1	11911(Tax:10090)	20296(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells .
25914608	0	ATF4	0,4	MCP-1	29,34	ATF4	MCP-1	11911(Tax:10090)	20296(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells .
12749859	0	ATF4	26,30	NIPK	6,10	ATF4	NIPK	11911(Tax:10090)	228775(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mouse NIPK interacts with ATF4 and affects its transcriptional activity .
26086088	0	ATF4	21,25	NLRP1	34,39	ATF4	NLRP1	468	22861	Gene	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Expression Expression|compound|END_ENTITY	Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress .
19946894	0	ATF4	133,137	Nuclear_protein_1	0,17	ATF4	Nuclear protein 1	468	26471	Gene	Gene	activation|nmod|START_ENTITY regulator|nmod|activation acts|nmod|regulator acts|nsubj|END_ENTITY	Nuclear_protein_1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4 .
19946894	0	ATF4	29,33	Nuclear_protein_1	0,17	ATF4	Nuclear protein 1	468	26471	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Nuclear_protein_1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4 .
21951999	0	ATF4	20,24	PHD1	0,4	ATF4	PHD1	468	112398	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation .
15109498	0	ATF4	0,4	RSK2	23,27	ATF4	RSK2	468	6197	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology ; implication for Coffin-Lowry_Syndrome .
21866569	0	ATF4	79,83	Twist1	48,54	ATF4	Twist1	468	7291	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts .
10509809	0	ATF4	47,51	activating_transcription_factor_4	12,45	ATF4	activating transcription factor 4	468	468	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of activating_transcription_factor_4 -LRB- ATF4 -RRB- in the porcine anterior pituitary .
24100623	0	ATF4	52,56	activating_transcription_factor_4	17,50	ATF4	activating transcription factor 4	468	468	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	SIRT1 suppresses activating_transcription_factor_4 -LRB- ATF4 -RRB- expression in response to proteasome inhibition .
24330582	0	ATF4	61,65	aryl_hydrocarbon_receptor	3,28	ATF4	aryl hydrocarbon receptor	468	196	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	An aryl_hydrocarbon_receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 .
10924469	0	ATF4	23,27	cryptocephal	4,16	ATF4	cryptocephal	47767(Tax:7227)	47767(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The cryptocephal gene -LRB- ATF4 -RRB- encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila .
23441162	0	ATF4	56,60	endothelin-1	25,37	ATF4	endothelin-1	468	1906	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells .
23242184	0	ATF4	82,86	erythropoietin	44,58	ATF4	erythropoietin	79255(Tax:10116)	24335(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY production|dep|role production|compound|END_ENTITY	Endoplasmic reticulum stress signal impairs erythropoietin production : a role for ATF4 .
23223004	0	ATF4	16,20	miR-214	0,7	ATF4	miR-214	468	406996	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-214 targets ATF4 to inhibit bone formation .
21212266	0	ATF5	32,36	BCL-2	0,5	ATF5	BCL-2	22809	596	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner .
21212266	0	ATF5	79,83	BCL-2	0,5	ATF5	BCL-2	22809	596	Gene	Gene	function|nmod|START_ENTITY mediates|dobj|function target|acl:relcl|mediates target|nsubj|END_ENTITY	BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner .
20654631	0	ATF5	87,91	CHOP	24,28	ATF5	CHOP	22809	1649	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells .
17606386	0	ATF5	0,4	Hsp27	66,71	ATF5	Hsp27	22809	3315	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells .
22528486	0	ATF5	75,79	activating_transcription_factor_5	40,73	ATF5	activating transcription factor 5	22809	22809	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Nucleophosmin -LRB- NPM1/B23 -RRB- interacts with activating_transcription_factor_5 -LRB- ATF5 -RRB- protein and promotes proteasome - and caspase-dependent ATF5 degradation in hepatocellular_carcinoma cells .
24379400	0	ATF5	73,77	activating_transcription_factor_5	38,71	ATF5	activating transcription factor 5	22809	22809	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	N-terminal hydrophobic amino_acids of activating_transcription_factor_5 -LRB- ATF5 -RRB- protein confer interleukin_1b -LRB- IL-1b -RRB- - induced stabilization .
21841196	0	ATF6	35,39	Activating_transcription_factor-6	0,33	ATF6	Activating transcription factor-6	22926	22926	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Activating_transcription_factor-6 -LRB- ATF6 -RRB- mediates apoptosis with reduction of myeloid_cell_leukemia_sequence_1 -LRB- Mcl-1 -RRB- protein via induction of WW_domain_binding_protein_1 .
22874566	0	ATF6	63,67	IFNG	0,4	ATF6	IFNG	226641(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	IFNG and autophagy : a critical role for the ER-stress mediator ATF6 in controlling bacterial_infections .
24746698	0	ATF6	21,25	VEGF	0,4	ATF6	VEGF	226641(Tax:10090)	22339(Tax:10090)	Gene	Gene	Signals|nmod|START_ENTITY Signals|nsubj|END_ENTITY	VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress .
24636989	0	ATF6a	60,65	PDIA5	99,104	ATF6a	PDIA5	22926	10954	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Endoplasmic reticulum stress-activated transcription factor ATF6a requires the disulfide isomerase PDIA5 to modulate chemoresistance .
21284983	0	ATF6a	98,103	PGC-1a	91,97	ATF6a	PGC-1a	226641(Tax:10090)	19017(Tax:10090)	Gene	Gene	complex|nmod:npmod|START_ENTITY END_ENTITY|amod|complex	The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a / ATF6a complex .
25447309	0	ATF6b	0,5	Wfs1	20,24	ATF6b	Wfs1	1388	7466	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	ATF6b regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic b-cells .
15890932	0	ATFx	30,34	Tax	85,88	ATFx	Tax	22809	1491938(Tax:11908)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The bZIP transcription factor ATFx binds human_T-cell_leukemia_virus_type_1 _ -LRB- HTLV-1 -RRB- Tax and represses HTLV-1 long terminal repeat-mediated transcription .
24119841	0	ATG1	35,39	ULK1	29,33	ATG1	ULK1	8408	8408	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Cyclic_dinucleotides trigger ULK1 -LRB- ATG1 -RRB- phosphorylation of STING to prevent sustained innate immune signaling .
21589871	0	ATG1	7,11	Unc-51	0,6	ATG1	Unc-51	39454(Tax:7227)	39454(Tax:7227)	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	Unc-51 / ATG1 controls axonal and dendritic development via kinesin-mediated vesicle transport in the Drosophila brain .
22885670	0	ATG101	15,21	Atg13	66,71	ATG101	Atg13	60673	176150(Tax:6239)	Gene	Gene	EPG-9|compound|START_ENTITY interacts|nsubj|EPG-9 interacts|nmod|END_ENTITY	The C. _ elegans ATG101 homolog EPG-9 directly interacts with EPG-1 / Atg13 and is essential for autophagy .
25883416	0	ATG16L1	19,26	CNTNAP3	0,7	ATG16L1	CNTNAP3	55054	79937	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	CNTNAP3 Associated ATG16L1 Expression and Crohn 's _ Disease .
18499543	0	ATG16L1	0,7	IL23R	27,32	ATG16L1	IL23R	55054	149233	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	ATG16L1 and IL23_receptor -LRB- IL23R -RRB- genes are associated with disease susceptibility in Hungarian_CD patients .
22350415	0	ATG2B	19,24	miRNA-130a	0,10	ATG2B	miRNA-130a	55102	406919	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic_lymphocytic_leukemia cells .
24269818	0	ATG8	66,70	GATE16	81,87	ATG8	GATE16	11345	11345	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	The Ca2 + channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy .
24269818	0	ATG8	66,70	TRPML3	17,23	ATG8	TRPML3	11345	55283	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Ca2 + channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy .
18224330	0	ATGL	29,33	Adipose_triglyceride_lipase	0,27	ATGL	Adipose triglyceride lipase	57104	57104	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Adipose_triglyceride_lipase -LRB- ATGL -RRB- expression in human skeletal muscle is type I -LRB- oxidative -RRB- fiber specific .
22836232	0	ATGL	29,33	Adipose_triglyceride_lipase	0,27	ATGL	Adipose triglyceride lipase	104928846	104928846	Gene	Gene	clone|compound|START_ENTITY clone|compound|END_ENTITY	Adipose_triglyceride_lipase -LRB- ATGL -RRB- clone , expression pattern , and regulation by different lipid sources and lipid levels in large_yellow_croaker -LRB- Pseudosciaena_crocea R. -RRB- .
23296636	0	ATGL	47,51	ERa	0,3	ATGL	ERa	66853(Tax:10090)	13982(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	ERa regulates lipid metabolism in bone through ATGL and perilipin .
23408028	0	ATGL	31,35	PLIN	16,20	ATGL	PLIN	361676(Tax:10116)	25629(Tax:10116)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Skeletal muscle PLIN proteins , ATGL and CGI-58 , interactions at rest and following stimulated contraction .
21393244	0	ATGL	50,54	adipose_triglyceride_lipase	21,48	ATGL	adipose triglyceride lipase	57104	57104	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Unique regulation of adipose_triglyceride_lipase -LRB- ATGL -RRB- by perilipin_5 , a lipid_droplet-associated_protein .
22039468	0	ATGL	51,55	adipose_triglyceride_lipase	22,49	ATGL	adipose triglyceride lipase	57104	57104	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The minimal domain of adipose_triglyceride_lipase -LRB- ATGL -RRB- ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2 , respectively .
21393244	0	ATGL	50,54	perilipin_5	59,70	ATGL	perilipin 5	57104	440503	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Unique regulation of adipose_triglyceride_lipase -LRB- ATGL -RRB- by perilipin_5 , a lipid_droplet-associated_protein .
12065416	0	ATHB6	20,25	ABI1	65,69	ATHB6	ABI1	816775(Tax:3702)	828714(Tax:3702)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Homeodomain protein ATHB6 is a target of the protein phosphatase ABI1 and regulates hormone responses in Arabidopsis .
10702393	0	ATIC-ALK	0,8	ALK	26,29	ATIC-ALK	ALK	471;238	238	Gene	Gene	START_ENTITY|dep|fusion fusion|compound|END_ENTITY	ATIC-ALK : A novel variant ALK gene fusion in anaplastic_large_cell_lymphoma resulting from the recurrent cryptic chromosomal inversion , inv -LRB- 2 -RRB- -LRB- p23q35 -RRB- .
20484506	0	ATIp	151,155	A27p	199,203	ATIp	A27p	57509	28912	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Congregation of orthopoxvirus virions in cytoplasmic A-type inclusions is mediated by interactions of a bridging protein -LRB- A26p -RRB- with a matrix protein -LRB- ATIp -RRB- and a virion membrane-associated protein -LRB- A27p -RRB- .
23660959	6	ATL	664,667	b-catenin	704,713	TCF	b-catenin	3172	1499	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|levels levels|nmod|END_ENTITY	Our study demonstrated that ATL cells do not express high levels of b-catenin but displayed high levels of LEF-1 / TCF genes along with elevated levels of b-catenin -LRB- LEF-1 / TCF target genes -RRB- responsive genes .
1681805	0	ATL-2	86,91	neu_protein-specific_activating_factor	36,74	ATL-2	neu protein-specific activating factor	64225	3576	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Isolation and characterization of a neu_protein-specific_activating_factor from human ATL-2 cell conditioned medium .
7694770	0	ATL-derived_factor	25,43	thioredoxin	53,64	ATL-derived factor	thioredoxin	7295	7295	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Astroglial expression of ATL-derived_factor , a human thioredoxin homologue , in the gerbil brain after transient global ischemia .
24399238	0	ATL31	17,22	Ubiquitin_ligase	0,16	ATL31	Ubiquitin ligase	832801(Tax:3702)	844276(Tax:3702)	Gene	Gene	functions|compound|START_ENTITY functions|amod|END_ENTITY	Ubiquitin_ligase ATL31 functions in leaf senescence in response to the balance between atmospheric CO2 and nitrogen availability in Arabidopsis .
22960274	0	ATM	0,3	AMPK	37,41	ATM	AMPK	472	5562	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis .
20740050	0	ATM	50,53	ATF2	69,73	ATM	ATF2	11920(Tax:10090)	11909(Tax:10090)	Gene	Gene	Mice|compound|START_ENTITY Mice|compound|END_ENTITY	Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice .
17459151	0	ATM	20,23	ATM	82,85	ATM	ATM	472	472	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|cells cells|compound|END_ENTITY	Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition .
17459151	0	ATM	82,85	ATM	20,23	ATM	ATM	472	472	Gene	Gene	cells|compound|START_ENTITY Interaction|nmod|cells Interaction|nmod|END_ENTITY	Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition .
17923702	0	ATM	49,52	ATM	63,66	ATM	ATM	472	472	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	DNA damage-induced acetylation of lysine_3016 of ATM activates ATM kinase activity .
17923702	0	ATM	63,66	ATM	49,52	ATM	ATM	472	472	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	DNA damage-induced acetylation of lysine_3016 of ATM activates ATM kinase activity .
19001856	0	ATM	15,18	ATM	45,48	ATM	ATM	472	472	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	ATMINistrating ATM signalling : regulation of ATM by ATMIN .
19001856	0	ATM	45,48	ATM	15,18	ATM	ATM	472	472	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	ATMINistrating ATM signalling : regulation of ATM by ATMIN .
16431910	0	ATM	55,58	ATR	20,23	ATM	ATR	472	545	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|activation activation|nmod|END_ENTITY	Rapid activation of ATR by ionizing radiation requires ATM and Mre11 .
17446169	0	ATM	108,111	ATR	60,63	ATM	ATR	398148(Tax:8355)	398197(Tax:8355)	Gene	Gene	occurs|nmod|START_ENTITY activation|acl:relcl|occurs activation|nmod|END_ENTITY	Ataxia-telangiectasia_mutated -LRB- ATM -RRB- - dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM .
17446169	0	ATM	31,34	ATR	60,63	ATM	ATR	398148(Tax:8355)	398197(Tax:8355)	Gene	Gene	Ataxia-telangiectasia_mutated|appos|START_ENTITY Ataxia-telangiectasia_mutated|dep|activation activation|nmod|END_ENTITY	Ataxia-telangiectasia_mutated -LRB- ATM -RRB- - dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM .
17478428	0	ATM	55,58	ATR	78,81	ATM	ATR	472	545	Gene	Gene	substrates|appos|START_ENTITY substrates|amod|ATM-Rad3-related ATM-Rad3-related|dep|END_ENTITY	A proteomic analysis of ataxia_telangiectasia-mutated -LRB- ATM -RRB- / ATM-Rad3-related -LRB- ATR -RRB- substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints .
18344416	0	ATM	121,124	ATR	22,25	ATM	ATR	472	545	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Differential roles of ATR and ATM in p53 , Chk1 , and histone_H2AX phosphorylation in response to hyperoxia : ATR-dependent ATM activation .
18757420	0	ATM	0,3	ATR	23,26	ATM	ATR	472	545	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	ATM acts downstream of ATR in the DNA damage response signaling of bystander cells .
20140190	0	ATM	88,91	ATR	39,42	ATM	ATR	472	545	Gene	Gene	Tel1|appos|START_ENTITY recruitment|nmod|Tel1 complex|nmod|recruitment Rad26|amod|complex role|dep|Rad26 role|nmod|Rad3 Rad3|appos|END_ENTITY	A kinase-independent role for the Rad3 -LRB- ATR -RRB- - Rad26 -LRB- ATRIP -RRB- complex in recruitment of Tel1 -LRB- ATM -RRB- to telomeres in fission_yeast .
21490603	0	ATM	21,24	ATR	78,81	ATM	ATR	472	545	Gene	Gene	cells|amod|START_ENTITY killing|nmod|cells Selective|dobj|killing Selective|nmod|inhibition inhibition|nmod|END_ENTITY	Selective killing of ATM - or p53-deficient cancer cells through inhibition of ATR .
25232030	0	ATM	111,114	ATR	58,61	ATM	ATR	472	545	Gene	Gene	Loss-of-function|compound|START_ENTITY Reveals|nmod|Loss-of-function Reveals|dobj|Sensitivity Sensitivity|nmod|Treatment Treatment|compound|END_ENTITY	A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle_Cell_Lymphoma with ATM Loss-of-function .
25497328	0	ATM	144,147	ATR	77,80	ATM	ATR	472	545	Gene	Gene	function|compound|START_ENTITY END_ENTITY|nmod|function	The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function .
14744748	0	ATM	31,34	Ataxia-telangiectasia-mutated	0,29	ATM	Ataxia-telangiectasia-mutated	472	472	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ataxia-telangiectasia-mutated -LRB- ATM -RRB- gene in head_and_neck_squamous_cell_carcinoma : promoter hypermethylation with clinical correlation in 100 cases .
20177072	0	ATM	31,34	Ataxia_telangiectasia_mutated	0,29	ATM	Ataxia telangiectasia mutated	472	472	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Ataxia_telangiectasia_mutated -LRB- ATM -RRB- inhibition transforms human mammary gland epithelial cells .
20177704	0	ATM	27,30	BRCA1	20,25	ATM	BRCA1	472	672	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|compound|END_ENTITY	Alterations in p53 , BRCA1 , ATM , PIK3CA , and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast_cancer .
26943323	0	ATM	20,23	Bcl-xL	72,78	ATM	Bcl-xL	11920(Tax:10090)	12048(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	PACS-2 mediates the ATM and NF-kB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage .
16325375	0	ATM	24,27	CKIP-1	0,6	ATM	CKIP-1	472	51177	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM .
24280901	0	ATM	0,3	Cdt1	14,18	ATM	Cdt1	472	81620	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication .
23857602	0	ATM	30,33	Estrogen_receptor_a	0,19	ATM	Estrogen receptor a	472	2099	Gene	Gene	Expression|compound|START_ENTITY regulates|dobj|Expression regulates|nsubj|END_ENTITY	Estrogen_receptor_a regulates ATM Expression through miRNAs in breast_cancer .
21518729	0	ATM	0,3	FOXM1	21,26	ATM	FOXM1	472	2305	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nummod|END_ENTITY	ATM and p53 regulate FOXM1 expression via E2F in breast_cancer epirubicin treatment and resistance .
11571274	0	ATM	0,3	H2AX	27,31	ATM	H2AX	472	3014	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	ATM phosphorylates histone H2AX in response to DNA double-strand breaks .
15389585	0	ATM	68,71	H2AX	8,12	ATM	H2AX	472	3014	Gene	Gene	kinases|nmod|START_ENTITY patterns|nmod|kinases patterns|compound|END_ENTITY	Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors .
16184611	0	ATM	14,17	H2AX	126,130	ATM	H2AX	472	3014	Gene	Gene	phosphorylation|compound|START_ENTITY Assessment|nmod|phosphorylation topoisomerase|nsubj|Assessment topoisomerase|ccomp|inhibitors inhibitors|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation , cell cycle phase , and apoptosis .
16426422	0	ATM	0,3	H2AX	27,31	ATM	H2AX	472	3014	Gene	Gene	activation|nsubj|START_ENTITY activation|dobj|phosphorylation phosphorylation|nummod|END_ENTITY	ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis .
20448412	0	ATM	0,3	H2AX	73,77	ATM	H2AX	472	3014	Gene	Gene	kinase|nsubj|START_ENTITY kinase|acl|involved involved|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating .
20888899	0	ATM	91,94	H2AX	31,35	ATM	H2AX	472	3014	Gene	Gene	kinases|nmod|START_ENTITY induces|nmod|kinases induces|dobj|patterns patterns|compound|END_ENTITY	Benzo -LSB- a -RSB- pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM , ATR , and DNA-PK .
26116906	0	ATM	105,108	H2AX	54,58	ATM	H2AX	472	3014	Gene	Gene	mediated|nmod|START_ENTITY lymphocytes|acl|mediated induce|nmod|lymphocytes induce|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Alpha particles induce pan-nuclear phosphorylation of H2AX in primary human lymphocytes mediated through ATM .
22614018	0	ATM	59,62	IKKb	35,39	ATM	IKKb	472	3551	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Promotion of DNA repair by nuclear IKKb phosphorylation of ATM in response to genotoxic stimuli .
26030852	0	ATM	0,3	IL-8	18,22	ATM	IL-8	472	3576	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion .
16163388	0	ATM	0,3	MDMX	42,46	ATM	MDMX	472	4194	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage .
15448142	0	ATM	30,33	Mcm2	0,4	ATM	Mcm2	398148(Tax:8355)	380451(Tax:8355)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses .
17672843	0	ATM	65,68	NBS1	0,4	ATM	NBS1	823975(Tax:3702)	821254(Tax:3702)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants .
19079347	0	ATM	0,3	NF-kappaB	26,35	ATM	NF-kappaB	472	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic_syndrome and acute_myeloid_leukemia .
25486363	0	ATM	37,40	Net1A	84,89	ATM	Net1A	472	10276	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Rho GTPase independent regulation of ATM activation and cell survival by the RhoGEF Net1A .
17459151	0	ATM	20,23	PARP	110,114	ATM	PARP	472	142	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition .
17459151	0	ATM	82,85	PARP	110,114	ATM	PARP	472	142	Gene	Gene	cells|compound|START_ENTITY Interaction|nmod|cells Interaction|nmod|END_ENTITY	Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition .
19717351	0	ATM	112,115	PARP	0,4	ATM	PARP	472	1302	Gene	Gene	mediated|nmod|START_ENTITY response|acl|mediated signals|dobj|response signals|nsubj|inhibition inhibition|compound|END_ENTITY	PARP inhibition during alkylation-induced genotoxic_stress signals a cell cycle checkpoint response mediated by ATM .
22416035	0	ATM	94,97	PARP	25,29	ATM	PARP	472	142	Gene	Gene	mutations|nmod|START_ENTITY inhibition|nmod|mutations inhibition|nsubj|cytotoxicity cytotoxicity|nmod|END_ENTITY	Enhanced cytotoxicity of PARP inhibition in mantle_cell_lymphoma harbouring mutations in both ATM and p53 .
21859827	0	ATM	64,67	Regulator_of_G_protein_signaling_6	0,34	ATM	Regulator of G protein signaling 6	472	9628	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Regulator_of_G_protein_signaling_6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species-dependent mechanism .
23852118	0	ATM	24,27	SIRT1	0,5	ATM	SIRT1	11920(Tax:10090)	93759(Tax:10090)	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons .
18848520	0	ATM	25,28	SNM1A	0,5	ATM	SNM1A	472	9937	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint .
25063542	0	ATM	15,18	Smad7	0,5	ATM	Smad7	11920(Tax:10090)	17131(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair .
24352200	0	ATM	24,27	TCTP	0,4	ATM	TCTP	41839(Tax:7227)	41341(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila_melanogaster .
22266654	0	ATM	0,3	TRF1	62,66	ATM	TRF1	472	7013	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	ATM regulates proteasome-dependent subnuclear localization of TRF1 , which is important for telomere maintenance .
19279141	0	ATM	62,65	TopBP1	52,58	ATM	TopBP1	398148(Tax:8355)	398573(Tax:8355)	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM .
12782595	0	ATM	65,68	WAF1	44,48	ATM	WAF1	472	1026	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Histone deacetylase inhibitors activate p21 -LRB- WAF1 -RRB- expression via ATM .
15177184	0	ATM	67,70	ataxia-telangiectasia_mutated	36,65	ATM	ataxia-telangiectasia mutated	472	472	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Biochemical characterization of the ataxia-telangiectasia_mutated -LRB- ATM -RRB- protein from human cells .
18634022	0	ATM	99,102	ataxia-telangiectasia_mutated	68,97	ATM	ataxia-telangiectasia mutated	472	472	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional and computational assessment of missense variants in the ataxia-telangiectasia_mutated -LRB- ATM -RRB- gene : mutations with increased cancer risk .
24324828	0	ATM	67,70	ataxia-telangiectasia_mutated	36,65	ATM	ataxia-telangiectasia mutated	472	472	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation at intronic repeats of the ataxia-telangiectasia_mutated -LRB- ATM -RRB- gene and ATM protein loss in primary gastric_cancer with microsatellite_instability .
16167060	0	ATM	72,75	ataxia_telangiectasia-mutated	41,70	ATM	ataxia telangiectasia-mutated	472	472	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Relation between genetic variants of the ataxia_telangiectasia-mutated -LRB- ATM -RRB- gene , drug resistance , clinical outcome and predisposition to childhood_T-lineage_acute_lymphoblastic_leukaemia .
12673126	0	ATM	46,49	ataxia_telangiectasia_mutated	15,44	ATM	ataxia telangiectasia mutated	472	472	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of ataxia_telangiectasia_mutated -LRB- ATM -RRB- gene mutation/deletion with rhabdomyosarcoma .
12969974	0	ATM	100,103	ataxia_telangiectasia_mutated	69,98	ATM	ataxia telangiectasia mutated	472	472	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of polymorphic variations of the ataxia_telangiectasia_mutated -LRB- ATM -RRB- gene in childhood Hodgkin_disease .
24421316	0	ATM	137,140	ataxia_telangiectasia_mutated	106,135	ATM	ataxia telangiectasia mutated	472	472	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia_telangiectasia_mutated -LRB- ATM -RRB- protein without DNA damage .
9707615	0	ATM	0,3	beta-adaptin	13,25	ATM	beta-adaptin	472	163	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	ATM binds to beta-adaptin in cytoplasmic vesicles .
20876284	0	ATM	0,3	cFLIP	30,35	ATM	cFLIP	472	8837	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	ATM kinase activity modulates cFLIP protein levels : potential interplay between DNA damage signalling and TRAIL-induced apoptosis .
23549171	0	ATM	0,3	hnRNPK	12,18	ATM	hnRNPK	472	3190	Gene	Gene	targets|compound|START_ENTITY END_ENTITY|nsubj|targets	ATM targets hnRNPK to control p53 .
22737216	0	ATM	55,58	miR-26b	0,7	ATM	miR-26b	472	407017	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular_atresia in porcine ovary .
12782595	0	ATM	65,68	p21	40,43	ATM	p21	472	1026	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Histone deacetylase inhibitors activate p21 -LRB- WAF1 -RRB- expression via ATM .
14757171	0	ATM	63,66	p21waf1/cip1	98,110	ATM	p21waf1/cip1	472	1026	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Genistein arrests hepatoma cells at G2/M phase : involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1 .
10082548	0	ATM	15,18	p53	51,54	ATM	p53	472	7157	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|nmod|protein protein|compound|END_ENTITY	Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks .
11468183	0	ATM	72,75	p53	0,3	ATM	p53	472	7157	Gene	Gene	inactivation|nmod|START_ENTITY dysfunction|dep|inactivation dysfunction|compound|END_ENTITY	p53 dysfunction in B-cell_chronic_lymphocytic_leukemia : inactivation of ATM as an alternative to TP53 mutation .
11526498	0	ATM	52,55	p53	14,17	ATM	p53	472	7157	Gene	Gene	domain|nmod:poss|START_ENTITY requires|dobj|domain requires|nsubj|Activation Activation|nmod|activity activity|compound|END_ENTITY	Activation of p53 transcriptional activity requires ATM 's kinase domain and multiple N-terminal serine residues of p53 .
12890678	0	ATM	132,135	p53	14,17	ATM	p53	472	7157	Gene	Gene	mutated|appos|START_ENTITY involves|dobj|mutated involves|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia_telangiectasia mutated -LRB- ATM -RRB- kinase activation .
15097860	0	ATM	14,17	p53	52,55	ATM	p53	472	7157	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|nmod|END_ENTITY	Expression of ATM protein and its relationship with p53 in pancreatic_carcinoma with tissue array .
16152627	0	ATM	32,35	p53	93,96	ATM	p53	472	7157	Gene	Gene	START_ENTITY|acl|signaling signaling|xcomp|stabilize stabilize|dobj|END_ENTITY	Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells .
16163388	0	ATM	0,3	p53	61,64	ATM	p53	472	7157	Gene	Gene	phosphorylation|amod|START_ENTITY contribute|nsubj|phosphorylation contribute|nmod|activation activation|compound|END_ENTITY	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage .
16849690	0	ATM	29,32	p53	125,128	ATM	p53	472	7157	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|dep|inactivation inactivation|nmod|activity activity|nmod|END_ENTITY	Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis : inactivation of its kinase activity toward p53 .
17292432	0	ATM	107,110	p53	19,22	ATM	p53	472	7157	Gene	Gene	pathway|compound|START_ENTITY involvement|nmod|pathway Phosphorylation|dep|involvement Phosphorylation|nmod|END_ENTITY	Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate : involvement of ATM pathway .
17417627	0	ATM	79,82	p53	0,3	ATM	p53	11920(Tax:10090)	22060(Tax:10090)	Gene	Gene	inactivating|dobj|START_ENTITY induce|advcl|inactivating mutants|xcomp|induce mutants|nsubj|cancer cancer|nummod|END_ENTITY	p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM .
18344416	0	ATM	121,124	p53	37,40	ATM	p53	472	7157	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Differential roles of ATR and ATM in p53 , Chk1 , and histone_H2AX phosphorylation in response to hyperoxia : ATR-dependent ATM activation .
19816404	0	ATM	0,3	p53	14,17	ATM	p53	472	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	ATM activates p53 by regulating MDM2 oligomerization and E3 processivity .
20081365	0	ATM	34,37	p53	13,16	ATM	p53	472	7157	Gene	Gene	stabilization|nmod|START_ENTITY stabilization|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of p53 stabilization by ATM after DNA damage .
21546907	0	ATM	102,105	p53	48,51	ATM	p53	472	7157	Gene	Gene	activation|nmod|START_ENTITY induction|nmod|activation apoptosis|dobj|induction apoptosis|nsubj|Abrogation Abrogation|nmod|expression expression|nmod|potentiates potentiates|compound|END_ENTITY	Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX .
22576881	0	ATM	0,3	p53	42,45	ATM	p53	472	7157	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage .
22893124	0	ATM	23,26	p53	34,37	ATM	p53	472	7157	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage .
23405218	0	ATM	27,30	p53	65,68	ATM	p53	472	7157	Gene	Gene	Daxx|nmod|START_ENTITY Phosphorylation|nmod|Daxx contributes|nsubj|Phosphorylation contributes|nmod|activation activation|compound|END_ENTITY	Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation .
23549171	0	ATM	0,3	p53	30,33	ATM	p53	472	7157	Gene	Gene	targets|compound|START_ENTITY hnRNPK|nsubj|targets hnRNPK|xcomp|control control|dobj|END_ENTITY	ATM targets hnRNPK to control p53 .
24813712	0	ATM	60,63	p53	23,26	ATM	p53	472	7157	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase mRNA|nmod|activation mRNA|compound|END_ENTITY	HDMX folds the nascent p53 mRNA following activation by the ATM kinase .
24841718	0	ATM	4,7	p53	44,47	ATM	p53	472	7157	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|correlates correlates|compound|END_ENTITY	Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric_cancer cell lines .
9733514	0	ATM	35,38	p53	28,31	ATM	p53	472	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Enhanced phosphorylation of p53 by ATM in response to DNA damage .
9733515	0	ATM	18,21	p53	74,77	ATM	p53	472	7157	Gene	Gene	Activation|nmod|START_ENTITY kinase|nsubj|Activation kinase|advcl|ionizing ionizing|dobj|radiation radiation|nmod|END_ENTITY	Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 .
10759527	0	ATMPK4	0,6	mitogen-activated_protein_kinase	34,66	ATMPK4	mitogen-activated protein kinase	828151(Tax:3702)	837559(Tax:3702)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	ATMPK4 , an Arabidopsis homolog of mitogen-activated_protein_kinase , is activated in vitro by AtMEK1 through threonine phosphorylation .
22985730	0	ATOH1	111,116	POU4F3	36,42	ATOH1	POU4F3	474	5459	Gene	Gene	enhance|nmod|START_ENTITY enhance|dobj|induction induction|nmod|END_ENTITY	TFE2 and GATA3 enhance induction of POU4F3 and myosin_VIIa positive cells in nonsensory cochlear epithelium by ATOH1 .
25015561	0	ATOH1	56,61	POU4F3	69,75	ATOH1	POU4F3	474	5459	Gene	Gene	START_ENTITY|nmod|Gene Gene|compound|END_ENTITY	Transcription Factors with Conserved Binding Sites Near ATOH1 on the POU4F3 Gene Enhance the Induction of Cochlear Hair Cells .
27049918	0	ATOH8	18,23	LMP1	47,51	ATOH8	LMP1	84913	9260	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal_carcinoma .
26004638	0	ATP-Binding_Cassette_Transporter	30,62	ABCA1	20,25	ATP-Binding Cassette Transporter	ABCA1	24	19	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Low Serum Levels of ABCA1 , an ATP-Binding_Cassette_Transporter , Are Predictive_of_Preeclampsia .
26510981	0	ATP-Binding_Cassette_Transporter-2	4,38	Amyloid_Precursor_Protein	116,141	ATP-Binding Cassette Transporter-2	Amyloid Precursor Protein	20	351	Gene	Gene	START_ENTITY|dep|Levels Levels|nmod|Gene Gene|compound|END_ENTITY	The ATP-Binding_Cassette_Transporter-2 -LRB- ABCA2 -RRB- Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid_Precursor_Protein -LRB- APP -RRB- Gene .
26743528	0	ATP-Binding_Cassette_Transporter_A1	57,92	Insulin-like_Growth_Factor_1	0,28	ATP-Binding Cassette Transporter A1	Insulin-like Growth Factor 1	313210(Tax:10116)	24482(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	Insulin-like_Growth_Factor_1 Regulates the Expression of ATP-Binding_Cassette_Transporter_A1 in Pancreatic Beta Cells .
17053191	0	ATP-Binding_cassette_transporter_A1	0,35	apolipoprotein_A-I	46,64	ATP-Binding cassette transporter A1	apolipoprotein A-I	19	335	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|transcytosis transcytosis|compound|END_ENTITY	ATP-Binding_cassette_transporter_A1 modulates apolipoprotein_A-I transcytosis through aortic endothelial cells .
20303467	0	ATP-binding-cassette-transporter-A1	12,47	ABCA1	49,54	ATP-binding-cassette-transporter-A1	ABCA1	19	19	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The role of ATP-binding-cassette-transporter-A1 -LRB- ABCA1 -RRB- gene polymorphism on coronary_artery_disease risk .
25170080	0	ATP-binding_Cassette_Transporter_A1	39,74	Calnexin	120,128	ATP-binding Cassette Transporter A1	Calnexin	19	821	Gene	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	HIV-1 Protein Nef Inhibits Activity of ATP-binding_Cassette_Transporter_A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin .
25170080	0	ATP-binding_Cassette_Transporter_A1	39,74	Nef	14,17	ATP-binding Cassette Transporter A1	Nef	19	6285	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	HIV-1 Protein Nef Inhibits Activity of ATP-binding_Cassette_Transporter_A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin .
17686774	0	ATP-binding_cassette	89,109	ABC	111,114	ATP-binding cassette	ABC	10058	10058	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding_cassette -LRB- ABC -RRB- transporter ABCG2 protein .
19067393	0	ATP-binding_cassette	18,38	ABC	40,43	ATP-binding cassette	ABC	10058	10058	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of placental ATP-binding_cassette -LRB- ABC -RRB- transporters in antiretroviral therapy during pregnancy .
17686774	0	ATP-binding_cassette	89,109	ABCG2	128,133	ATP-binding cassette	ABCG2	10058	9429	Gene	Gene	protein|amod|START_ENTITY protein|nummod|END_ENTITY	Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding_cassette -LRB- ABC -RRB- transporter ABCG2 protein .
24016265	0	ATP-binding_cassette_A1	29,52	ABCA1	62,67	ATP-binding cassette A1	ABCA1	19	19	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The target of regulating the ATP-binding_cassette_A1 protein -LRB- ABCA1 -RRB- : promoting ABCA1-mediated cholesterol efflux in different cells .
16982432	0	ATP-binding_cassette_A1	41,64	THP-1	68,73	ATP-binding cassette A1	THP-1	19	2736	Gene	Gene	START_ENTITY|nmod|macrophages macrophages|compound|END_ENTITY	-LSB- Modulation of inflammatory cytokines by ATP-binding_cassette_A1 in THP-1 macrophages -RSB- .
22772754	0	ATP-binding_cassette_G1	6,29	lipoprotein_lipase	50,68	ATP-binding cassette G1	lipoprotein lipase	9619	4023	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Human ATP-binding_cassette_G1 controls macrophage lipoprotein_lipase bioavailability and promotes foam cell formation .
20704561	0	ATP-binding_cassette_transporter-2	4,38	amyloid_precursor_protein	68,93	ATP-binding cassette transporter-2	amyloid precursor protein	20	351	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	The ATP-binding_cassette_transporter-2 -LRB- ABCA2 -RRB- increases endogenous amyloid_precursor_protein expression and Ab fragment generation .
16254209	0	ATP-binding_cassette_transporter-A1	34,69	Glucocorticoid_receptor	0,23	ATP-binding cassette transporter-A1	Glucocorticoid receptor	19	2908	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glucocorticoid_receptor regulates ATP-binding_cassette_transporter-A1 expression and apolipoprotein-mediated cholesterol efflux from macrophages .
11558901	0	ATP-binding_cassette_transporter_A1	102,137	ABCA1	139,144	ATP-binding cassette transporter A1	ABCA1	19	19	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	High-density single-nucleotide polymorphism -LRB- SNP -RRB- map of the 150-kb region corresponding to the human ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- gene .
12111381	0	ATP-binding_cassette_transporter_A1	84,119	ABCA1	122,127	ATP-binding cassette transporter A1	ABCA1	19	19	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- gene in Japanese patients with Tangier_disease .
22982414	0	ATP-binding_cassette_transporter_A1	41,76	ABCA1	83,88	ATP-binding cassette transporter A1	ABCA1	19	19	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Meta-analysis on association between the ATP-binding_cassette_transporter_A1 gene -LRB- ABCA1 -RRB- and Alzheimer 's _ disease .
22020260	0	ATP-binding_cassette_transporter_A1	109,144	Acyl-CoA_synthetase_1	0,21	ATP-binding cassette transporter A1	Acyl-CoA synthetase 1	11303(Tax:10090)	14081(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Acyl-CoA_synthetase_1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding_cassette_transporter_A1 in macrophages .
17906976	0	ATP-binding_cassette_transporter_A1	99,134	Apolipoprotein_A-I	0,18	ATP-binding cassette transporter A1	Apolipoprotein A-I	19	335	Gene	Gene	roles|nmod|START_ENTITY macrophages|dep|roles internalised|nmod|macrophages internalised|nsubjpass|lipoproteins lipoproteins|amod|END_ENTITY	Apolipoprotein_A-I but not high-density lipoproteins are internalised by RAW macrophages : roles of ATP-binding_cassette_transporter_A1 and scavenger_receptor_BI .
22498566	0	ATP-binding_cassette_transporter_A1	56,91	Interleukin-18	0,14	ATP-binding cassette transporter A1	Interleukin-18	19	3606	Gene	Gene	expression|compound|START_ENTITY downregulate|dobj|expression downregulate|nsubj|END_ENTITY	Interleukin-18 and interleukin-12 together downregulate ATP-binding_cassette_transporter_A1 expression through the interleukin-18R / nuclear factor-kB signaling pathway in THP-1 macrophage-derived foam cells .
12890677	0	ATP-binding_cassette_transporter_A1	102,137	apolipoprotein_A-I	40,58	ATP-binding cassette transporter A1	apolipoprotein A-I	100761226	100772590	Gene	Gene	presence|nmod|START_ENTITY increasing|dobj|presence END_ENTITY|advcl|increasing	Ceramide enhances cholesterol efflux to apolipoprotein_A-I by increasing the cell surface presence of ATP-binding_cassette_transporter_A1 .
14660648	0	ATP-binding_cassette_transporter_A1	74,109	apolipoprotein_A-I	37,55	ATP-binding cassette transporter A1	apolipoprotein A-I	19	335	Gene	Gene	lipidation|nmod|START_ENTITY lipidation|nsubj|physiology physiology|nmod|END_ENTITY	Molecular and cellular physiology of apolipoprotein_A-I lipidation by the ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- .
20208418	0	ATP-binding_cassette_transporter_A1	94,129	apolipoprotein_A-I	9,27	ATP-binding cassette transporter A1	apolipoprotein A-I	11303(Tax:10090)	11806(Tax:10090)	Gene	Gene	macrophages|nmod|START_ENTITY promotes|nmod|macrophages promotes|nsubj|D-4F D-4F|appos|peptide peptide|amod|END_ENTITY	D-4F , an apolipoprotein_A-I mimetic peptide , promotes cholesterol efflux from macrophages via ATP-binding_cassette_transporter_A1 .
21734188	0	ATP-binding_cassette_transporter_A1	120,155	apolipoprotein_A-I	6,24	ATP-binding cassette transporter A1	apolipoprotein A-I	19	335	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Human apolipoprotein_A-I induces cyclooxygenase-2 expression and prostaglandin_I-2 release in endothelial cells through ATP-binding_cassette_transporter_A1 .
22271762	0	ATP-binding_cassette_transporter_A1	41,76	apolipoprotein_A-I	11,29	ATP-binding cassette transporter A1	apolipoprotein A-I	19	335	Gene	Gene	signaling|nsubj|START_ENTITY stabilizes|xcomp|signaling stabilizes|nsubj|END_ENTITY	Endogenous apolipoprotein_A-I stabilizes ATP-binding_cassette_transporter_A1 and modulates Toll-like_receptor_4 signaling in human macrophages .
22399138	0	ATP-binding_cassette_transporter_A1	105,140	apolipoprotein_A-I	83,101	ATP-binding cassette transporter A1	apolipoprotein A-I	19	335	Gene	Gene	increasing|nmod|START_ENTITY increasing|dobj|binding binding|nmod|END_ENTITY	IMB2026791 , a xanthone , stimulates cholesterol efflux by increasing the binding of apolipoprotein_A-I to ATP-binding_cassette_transporter_A1 .
11566359	0	ATP-binding_cassette_transporter_G2	98,133	breast_cancer_resistance_protein	64,96	ATP-binding cassette transporter G2	breast cancer resistance protein	9429	9429	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Promoter characterization and genomic organization of the human breast_cancer_resistance_protein -LRB- ATP-binding_cassette_transporter_G2 -RRB- gene .
23897429	0	ATP-citrate_lyase	22,39	DNMT1	0,5	ATP-citrate lyase	DNMT1	47	1786	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	DNMT1 is regulated by ATP-citrate_lyase and maintains methylation patterns during adipocyte differentiation .
6433906	0	ATP-citrate_lyase	74,91	Insulin	0,7	ATP-citrate lyase	Insulin	47	3630	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Insulin stimulates the dephosphorylation of phosphothreonine from fat-pad ATP-citrate_lyase .
7665595	0	ATP-citrate_lyase	19,36	nucleoside_diphosphate_kinase	40,69	ATP-citrate lyase	nucleoside diphosphate kinase	24159(Tax:10116)	298410(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of ATP-citrate_lyase by nucleoside_diphosphate_kinase .
17234742	0	ATP-dependent_interferon-responsive	114,149	ADIR	151,155	ATP-dependent interferon-responsive	ADIR	64222	64222	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple_myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent_interferon-responsive -LRB- ADIR -RRB- gene .
20310007	0	ATP13A2	0,7	PARK9	19,24	ATP13A2	PARK9	23400	23400	Gene	Gene	mutations|nummod|START_ENTITY mutations|appos|END_ENTITY	ATP13A2 mutations -LRB- PARK9 -RRB- cause neurodegeneration_with_brain_iron_accumulation .
22288903	0	ATP13A2	22,29	PARK9	31,36	ATP13A2	PARK9	23400	23400	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hypoxia regulation of ATP13A2 -LRB- PARK9 -RRB- gene transcription .
26421390	0	ATP13A2	70,77	PARK9	79,84	ATP13A2	PARK9	23400	23400	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Juvenile_dystonia-parkinsonism syndrome caused by a novel p.S941Tfs1X ATP13A2 -LRB- PARK9 -RRB- mutation .
25533462	0	ATP1A1	18,24	Fibroblast_Growth_Factor_2	56,82	ATP1A1	Fibroblast Growth Factor 2	476	2247	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Secretion Secretion|nmod|END_ENTITY	A Direct Role for ATP1A1 in Unconventional Secretion of Fibroblast_Growth_Factor_2 .
12230809	0	ATP1AL1	14,21	proton_pump	37,48	ATP1AL1	proton pump	479	479	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ATP1AL1 , a non-gastric proton_pump , in human colorectum .
17597815	0	ATP2A2	38,44	Sp1	8,11	ATP2A2	Sp1	488	6667	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes .
25798335	0	ATP2B4	7,13	PMCA4	0,5	ATP2B4	PMCA4	493	491	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	PMCA4 -LRB- ATP2B4 -RRB- mutation in familial_spastic_paraplegia causes delay in intracellular calcium extrusion .
15955096	0	ATP2C1	30,36	Sp1	45,48	ATP2C1	Sp1	27032	6667	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey_disease keratinocytes .
2194802	0	ATP4	13,17	phosphoglycerate_kinase	48,71	ATP4	phosphoglycerate kinase	856027(Tax:4932)	850370(Tax:4932)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of ATP4 - and Mg2 + in control steps of phosphoglycerate_kinase .
21616089	0	ATP5a1	45,51	aryl_hydrocarbon_receptor	4,29	ATP5a1	aryl hydrocarbon receptor	11946(Tax:10090)	11622(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor interacts with ATP5a1 , a subunit of the ATP synthase complex , and modulates mitochondrial function .
26177453	0	ATP6V1B2	38,46	SIRT1	0,5	ATP6V1B2	SIRT1	526	23411	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes .
24735419	0	ATP7A	41,46	ATPase	74,80	ATP7A	ATPase	538	1769	Gene	Gene	investigations|nmod|START_ENTITY investigations|dep|copper copper|appos|END_ENTITY	Translational research investigations on ATP7A : an important human copper ATPase .
24058603	0	ATP7B	34,39	BRCA1	20,25	ATP7B	BRCA1	540	672	Gene	Gene	TOPOI|appos|START_ENTITY TOPOI|compound|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
15523622	0	ATP7B	93,98	Wilson_disease	72,86	ATP7B	Wilson disease	540	540	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotype-phenotype correlations for a wide spectrum of mutations in the Wilson_disease gene -LRB- ATP7B -RRB- .
16554302	0	ATP7B	76,81	dynactin_subunit_p62	32,52	ATP7B	dynactin subunit p62	540	51164	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Copper-dependent interaction of dynactin_subunit_p62 with the N terminus of ATP7B but not ATP7A .
21189263	0	ATP7B	65,70	protein_kinase_D	15,31	ATP7B	protein kinase D	540	5587	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of protein_kinase_D in expression and trafficking of ATP7B -LRB- copper ATPase -RRB- .
24027241	0	ATPS1	25,30	ATP_sulfurylase	42,57	ATPS1	ATP sulfurylase	840337(Tax:3702)	827118(Tax:3702)	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	Natural variation in the ATPS1 isoform of ATP_sulfurylase contributes to the control of sulfate levels in Arabidopsis .
22456339	0	ATP_binding_cassette	27,47	ABC	49,52	ATP binding cassette	ABC	10058	10058	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Expression of the 49 human ATP_binding_cassette -LRB- ABC -RRB- genes in pluripotent embryonic stem cells and in early - and late-stage multipotent mesenchymal stem cells : possible role of ABC plasma membrane transporters in maintaining human stem cell pluripotency .
24948812	0	ATP_binding_cassette_transporter	17,49	Nrf2	0,4	ATP binding cassette transporter	Nrf2	76408(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Nrf2 upregulates ATP_binding_cassette_transporter expression and activity at the blood-brain and blood-spinal cord barriers .
20338636	0	ATP_binding_cassette_transporter_A1	31,66	ABCA1	68,73	ATP binding cassette transporter A1	ABCA1	19	19	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of ATP_binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- in first trimester and term human placenta .
14673498	0	ATP_binding_cassette_transporter_A1	22,57	THP-1	95,100	ATP binding cassette transporter A1	THP-1	19	2736	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Effects of oleate on ATP_binding_cassette_transporter_A1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells -RSB- .
11279031	0	ATP_binding_cassette_transporter_A1	71,106	zinc_finger_protein_202	4,27	ATP binding cassette transporter A1	zinc finger protein 202	19	7753	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	The zinc_finger_protein_202 -LRB- ZNF202 -RRB- is a transcriptional repressor of ATP_binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- and ABCG1 gene expression and a modulator of cellular lipid efflux .
1458840	0	ATP_citrate_lyase	45,62	Epidermal_growth_factor	0,23	ATP citrate lyase	Epidermal growth factor	24159(Tax:10116)	25313(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity stimulation|amod|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- stimulation of ATP_citrate_lyase activity in isolated rat hepatocytes is age dependent .
24027241	0	ATP_sulfurylase	42,57	ATPS1	25,30	ATP sulfurylase	ATPS1	827118(Tax:3702)	840337(Tax:3702)	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	Natural variation in the ATPS1 isoform of ATP_sulfurylase contributes to the control of sulfate levels in Arabidopsis .
23770099	0	ATPase	22,28	ABCG1	64,69	ATPase	ABCG1	1769	9619	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Resveratrol modulates ATPase activity of liposome-reconstituted ABCG1 .
24735419	0	ATPase	74,80	ATP7A	41,46	ATPase	ATP7A	1769	538	Gene	Gene	copper|appos|START_ENTITY investigations|dep|copper investigations|nmod|END_ENTITY	Translational research investigations on ATP7A : an important human copper ATPase .
1351891	0	ATPase	1,7	ATPase	59,65	ATPase	ATPase	13417(Tax:10090)	13417(Tax:10090)	Gene	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	-LSB- ATPase positive epidermal Langerhans cells : inhibition of ATPase by ammonium_bituminosulfonate -LRB- Ichthyol -RRB- and pix lithanthracis -RSB- .
1351891	0	ATPase	59,65	ATPase	1,7	ATPase	ATPase	13417(Tax:10090)	13417(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	-LSB- ATPase positive epidermal Langerhans cells : inhibition of ATPase by ammonium_bituminosulfonate -LRB- Ichthyol -RRB- and pix lithanthracis -RSB- .
227843	0	ATPase	40,46	ATPase	58,64	ATPase	ATPase	1769	1769	Gene	Gene	START_ENTITY|nmod|reaction reaction|compound|END_ENTITY	Binding of ouabain to Na + , K + - dependent ATPase during the ATPase reaction .
227843	0	ATPase	58,64	ATPase	40,46	ATPase	ATPase	1769	1769	Gene	Gene	reaction|compound|START_ENTITY END_ENTITY|nmod|reaction	Binding of ouabain to Na + , K + - dependent ATPase during the ATPase reaction .
6299346	0	ATPase	26,32	ATPase	74,80	ATPase	ATPase	1769	1769	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|dep|END_ENTITY	Calcium inhibition of the ATPase and phosphatase activities of -LRB- Na + + K + -RRB- - ATPase .
6299346	0	ATPase	74,80	ATPase	26,32	ATPase	ATPase	1769	1769	Gene	Gene	inhibition|dep|START_ENTITY inhibition|nmod|END_ENTITY	Calcium inhibition of the ATPase and phosphatase activities of -LRB- Na + + K + -RRB- - ATPase .
10347168	0	ATPase	4,10	ArsA	24,28	ATPase	ArsA	1769	410	Gene	Gene	mechanism|amod|START_ENTITY mechanism|nmod|END_ENTITY	The ATPase mechanism of ArsA , the catalytic subunit of the arsenite pump .
12538877	0	ATPase	88,94	Atox1	19,24	ATPase	Atox1	1769	475	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase .
23776592	0	ATPase	89,95	Atp7a	97,102	ATPase	Atp7a	13417(Tax:10090)	11977(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Investigation of iron metabolism in mice expressing a mutant Menke 's copper transporting ATPase -LRB- Atp7a -RRB- protein with diminished activity -LRB- Brindled ; Mo -LRB- Br -RRB- -LRB- / y -RRB- -RRB- .
17582821	0	ATPase	106,112	BRG1	82,86	ATPase	BRG1	1769	6597	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein , a central ATPase of the SWI/SNF remodeling complex .
19789351	0	ATPase	94,100	BRG1	84,88	ATPase	BRG1	1769	6597	Gene	Gene	dependent|dep|START_ENTITY dependent|nmod|activity activity|nmod|END_ENTITY	Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1 , the ATPase of the SWI/SNF chromatin remodeling complex .
12242406	0	ATPase	65,71	Bean	95,99	ATPase	Bean	1769	146227	Gene	Gene	START_ENTITY|nmod|Cells Cells|nmod|END_ENTITY	Cytosolic Concentration of Ca2 + Regulates the Plasma Membrane H + - ATPase in Guard Cells of Fava Bean .
11541960	0	ATPase	32,38	CA2	51,54	ATPase	CA2	1769	760	Gene	Gene	activity|amod|START_ENTITY mitochondrial|dobj|activity mitochondrial|nmod|+ +|compound|END_ENTITY	Modulation of oat mitochondrial ATPase activity by CA2 + and phytochrome .
1351813	0	ATPase	48,54	Ca2	15,18	ATPase	Ca2	1769	760	Gene	Gene	ATPase|dep|START_ENTITY ATPase|amod|END_ENTITY	High affinity , Ca2 + specific ATPase and Na + K -LRB- + -RRB- - ATPase in the gills of a supralittoral crab Leptograpsus variegatus .
2144382	0	ATPase	38,44	Ca2	28,31	ATPase	Ca2	1769	760	Gene	Gene	Reconstruction|dep|START_ENTITY Reconstruction|nmod|+ +|compound|END_ENTITY	-LSB- Reconstruction of purified Ca2 + , Mg2 + - ATPase from the myometrium sarcolemma into liposomes and its catalytic properties -RSB- .
7876199	0	ATPase	92,98	Ca2	38,41	ATPase	Ca2	1769	760	Gene	Gene	+|nmod|START_ENTITY +|nsubj|efficiency efficiency|nmod|+ +|amod|END_ENTITY	Variable stoichiometric efficiency of Ca2 + and Sr2 + transport by the sarcoplasmic reticulum ATPase .
9989931	0	ATPase	87,93	Ca2	82,85	ATPase	Ca2	1769	760	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Effects of various amino_acid 256 mutations on sarcoplasmic/endoplasmic reticulum Ca2 + ATPase function and their role in the cellular adaptive response to thapsigargin .
16342954	0	ATPase	0,6	Eg5	20,23	ATPase	Eg5	1769	3832	Gene	Gene	mechanism|amod|START_ENTITY mechanism|nmod|END_ENTITY	ATPase mechanism of Eg5 in the absence of microtubules : insight into microtubule activation and allosteric inhibition by monastrol .
19150983	0	ATPase	21,27	FANCJ	0,5	ATPase	FANCJ	1769	83990	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	FANCJ uses its motor ATPase to destabilize protein-DNA complexes , unwind triplexes , and inhibit RAD51 strand exchange .
19648242	0	ATPase	79,85	FliI	69,73	ATPase	FliI	1769	2314	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|appos|secretion	Flagellar formation in C-ring-defective mutants by overproduction of FliI , the ATPase specific for flagellar type III secretion .
12680712	0	ATPase	4,10	GroEL	23,28	ATPase	GroEL	1769	3329	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The ATPase activity of GroEL is supported at high temperatures by divalent cations that stabilize its structure .
15533935	0	ATPase	76,82	HSP90	25,30	ATPase	HSP90	13417(Tax:10090)	111058(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY stimulation|nmod|activity Association|dep|stimulation Association|nmod|NASP NASP|nmod|END_ENTITY	Association of NASP with HSP90 in mouse spermatogenic cells : stimulation of ATPase activity and transport of linker histones into nuclei .
23321985	0	ATPase	25,31	HSP90	35,40	ATPase	HSP90	13417(Tax:10090)	111058(Tax:10090)	Gene	Gene	START_ENTITY|nmod|attenuates attenuates|nummod|END_ENTITY	Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function .
26991466	0	ATPase	45,51	HSP90	4,9	ATPase	HSP90	1769	3320	Gene	Gene	chaperone|dep|START_ENTITY chaperone|compound|END_ENTITY	The HSP90 molecular chaperone - an enigmatic ATPase .
21530495	0	ATPase	77,83	HSPA9	71,76	ATPase	HSPA9	1769	3313	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity .
18657319	0	ATPase	31,37	Hsp70	76,81	ATPase	Hsp70	1769	3308	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Distinct binding sites for the ATPase and substrate-binding domain of human Hsp70 on the cell surface of antigen_presenting_cells .
14739935	0	ATPase	40,46	Hsp90	69,74	ATPase	Hsp90	1769	3320	Gene	Gene	activator|compound|START_ENTITY recruitment|nmod|activator basis|nmod|recruitment Aha1|nsubj|basis Aha1|nmod|machinery machinery|amod|END_ENTITY	Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery .
15039704	0	ATPase	40,46	Hsp90	69,74	ATPase	Hsp90	1769	3320	Gene	Gene	activator|compound|START_ENTITY recruitment|nmod|activator basis|nmod|recruitment Aha1|nsubj|basis Aha1|nmod|machinery machinery|amod|END_ENTITY	Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery .
15937123	0	ATPase	56,62	Hsp90	19,24	ATPase	Hsp90	1769	3320	Gene	Gene	inhibition|nmod|START_ENTITY promotes|dobj|inhibition promotes|nsubj|S-nitrosylation S-nitrosylation|nmod|END_ENTITY	S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric_oxide synthase regulatory activities .
18400751	0	ATPase	40,46	Hsp90	62,67	ATPase	Hsp90	1769	3320	Gene	Gene	cycle|compound|START_ENTITY changes|nmod|cycle changes|nmod|END_ENTITY	Conserved conformational changes in the ATPase cycle of human Hsp90 .
19856130	0	ATPase	42,48	Hsp90	61,66	ATPase	Hsp90	1769	3320	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype .
20089831	0	ATPase	61,67	Hsp90	55,60	ATPase	Hsp90	1769	3320	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic_fibrosis .
20226818	0	ATPase	35,41	Hsp90	29,34	ATPase	Hsp90	1769	3320	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo .
20376192	0	ATPase	49,55	Hsp90	23,28	ATPase	Hsp90	1769	3320	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity .
8419347	0	ATPase	26,32	Hsp90	0,5	ATPase	Hsp90	1769	299331(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY possess|dobj|activity possess|nsubj|chaperonins chaperonins|amod|END_ENTITY	Hsp90 chaperonins possess ATPase activity and bind heat_shock transcription factors and peptidyl prolyl isomerases .
22167269	0	ATPase	37,43	ISWI	32,36	ATPase	ISWI	1769	6594	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry .
25499980	0	ATPase	31,37	Leptin	0,6	ATPase	Leptin	1769	3952	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Leptin inhibits the Na -LRB- + -RRB- / K -LRB- + -RRB- ATPase in Caco-2 cells via PKC and p38MAPK .
162581	1	ATPase	90,96	Mg2	68,71	ATPase	Mg2	1769	4589	Gene	Gene	activity|amod|START_ENTITY +|dobj|activity +|nsubj|modification modification|nmod|END_ENTITY	Ca2 + modification of Mg2 + dependent dynein ATPase activity .
6148777	0	ATPase	64,70	Mg2	59,62	ATPase	Mg2	1769	4589	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Influence of myosin antiserum on heart sarcolemmal Ca2 + or Mg2 + ATPase activity .
14568978	0	ATPase	5,11	Msh2	0,4	ATPase	Msh2	13417(Tax:10090)	17685(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination .
10090768	0	ATPase	103,109	Myosin	47,53	ATPase	Myosin	1769	79784	Gene	Gene	cycle|compound|START_ENTITY affects|nmod|cycle affects|dobj|affinity affinity|nmod:poss|END_ENTITY	The sequence of the myosin 50-20K loop affects Myosin 's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity .
124738	0	ATPase	7,13	Myosin	0,6	ATPase	Myosin	1769	79784	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Myosin ATPase activity in multifidus muscle from cases of lumbar spinal derangement .
22064235	0	ATPase	91,97	Myosin	0,6	ATPase	Myosin	1769	79784	Gene	Gene	susceptibility|nmod|START_ENTITY influences|dobj|susceptibility influences|nsubj|composition composition|amod|END_ENTITY	Myosin heavy chain isoform composition influences the susceptibility of actin-activated S1 ATPase and myofibrillar ATPase to pH inactivation .
6213431	0	ATPase	37,43	Myosin	0,6	ATPase	Myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Myosin phosphorylation regulates the ATPase activity of permeable skeletal muscle fibers .
7961908	0	ATPase	4,10	N-ethylmaleimide-sensitive_fusion_protein	23,64	ATPase	N-ethylmaleimide-sensitive fusion protein	1769	4905	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The ATPase activity of N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is regulated by soluble NSF attachment proteins .
7961908	0	ATPase	4,10	NSF	66,69	ATPase	NSF	1769	4905	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The ATPase activity of N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is regulated by soluble NSF attachment proteins .
7961908	0	ATPase	4,10	NSF	95,98	ATPase	NSF	1769	4905	Gene	Gene	activity|amod|START_ENTITY regulated|nsubjpass|activity regulated|nmod|proteins proteins|compound|END_ENTITY	The ATPase activity of N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is regulated by soluble NSF attachment proteins .
9762911	0	ATPase	43,49	NSF	53,56	ATPase	NSF	1769	4905	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of SNAP/SNARE complexes on the ATPase of NSF .
18693757	0	ATPase	30,36	NTPDase3	112,120	ATPase	NTPDase3	1769	956	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding .
18693757	0	ATPase	30,36	NTPDase3	73,81	ATPase	NTPDase3	1769	956	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding .
25594233	0	ATPase	90,96	P-Glycoprotein	34,48	ATPase	P-Glycoprotein	1769	5243	Gene	Gene	Activity|compound|START_ENTITY Function|nmod|Activity Function|compound|END_ENTITY	Demethoxycurcumin Modulates Human P-Glycoprotein Function via Uncompetitive Inhibition of ATPase Hydrolysis Activity .
10727524	0	ATPase	70,76	P-glycoprotein	98,112	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activity|amod|START_ENTITY associated|nmod|activity associated|nmod|END_ENTITY	Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe -LRB- 335 -RRB- .
10806188	0	ATPase	16,22	P-glycoprotein	41,55	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites .
11598005	0	ATPase	78,84	P-glycoprotein	42,56	ATPase	P-glycoprotein	1769	5243	Gene	Gene	cycle|compound|START_ENTITY domains|nmod|cycle domains|nmod|END_ENTITY	Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle .
11926837	0	ATPase	40,46	P-glycoprotein	95,109	ATPase	P-glycoprotein	1769	5243	Gene	Gene	Hoechst_33342|nmod|START_ENTITY bound|dep|Hoechst_33342 sites|amod|bound Proximity|nmod|sites places|nsubj|Proximity places|dobj|site site|nmod|END_ENTITY	Proximity of bound Hoechst_33342 to the ATPase catalytic sites places the drug binding site of P-glycoprotein within the cytoplasmic membrane leaflet .
12055198	0	ATPase	84,90	P-glycoprotein	55,69	ATPase	P-glycoprotein	1769	5243	Gene	Gene	Function|compound|START_ENTITY Modulates|dobj|Function Modulates|nsubj|Cleavage Cleavage|nmod|Region Region|nmod|END_ENTITY	Proteolytic Cleavage of the Linker Region of the Human P-glycoprotein Modulates Its ATPase Function .
17367162	0	ATPase	90,96	P-glycoprotein	27,41	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activity|amod|START_ENTITY influence|nmod|activity Mechanism|dep|influence Mechanism|nmod|inhibition inhibition|nmod|efflux efflux|amod|END_ENTITY	Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin_E_TPGS : influence on ATPase activity and membrane fluidity .
18937360	0	ATPase	94,100	P-glycoprotein	35,49	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activities|compound|START_ENTITY effects|nmod|activities activation|dep|effects activation|nmod|END_ENTITY	Cholesterol-mediated activation of P-glycoprotein : distinct effects on basal and drug-induced ATPase activities .
20004641	0	ATPase	80,86	P-glycoprotein	0,14	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activity|compound|START_ENTITY comparing|dobj|activity assessed|advcl|comparing assessed|nsubj|transport transport|amod|END_ENTITY	P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity .
23720244	0	ATPase	40,46	P-glycoprotein	50,64	ATPase	P-glycoprotein	1769	5243	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|cells cells|amod|END_ENTITY	Interaction of CJY , an isoflavone , with ATPase of P-glycoprotein in doxorubicin-resistant human myelogenous_leukemia -LRB- K562/DOX -RRB- cells .
24523403	0	ATPase	106,112	P-glycoprotein	64,78	ATPase	P-glycoprotein	1769	5243	Gene	Gene	switch|compound|START_ENTITY triggers|dobj|switch END_ENTITY|acl:relcl|triggers	Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch .
7629050	0	ATPase	16,22	P-glycoprotein	45,59	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Drug-stimulated ATPase activity of the human P-glycoprotein .
7665554	0	ATPase	169,175	P-glycoprotein	28,42	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activities|compound|START_ENTITY chromatography|nmod|activities expressed|nmod|chromatography expressed|nsubj|purification purification|nmod|mutants mutants|amod|END_ENTITY	Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities .
7907331	0	ATPase	34,40	P-glycoprotein	96,110	ATPase	P-glycoprotein	1769	5243	Gene	Gene	co-expression|compound|START_ENTITY co-expression|nmod|half half|nmod|END_ENTITY	Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides .
9016791	0	ATPase	25,31	P-glycoprotein	35,49	ATPase	P-glycoprotein	1769	5243	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Functional modulation of ATPase of P-glycoprotein by C219 , a monoclonal antibody against P-glycoprotein .
9016791	0	ATPase	25,31	P-glycoprotein	89,103	ATPase	P-glycoprotein	1769	5243	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|C219 C219|appos|antibody antibody|nmod|END_ENTITY	Functional modulation of ATPase of P-glycoprotein by C219 , a monoclonal antibody against P-glycoprotein .
9528676	0	ATPase	35,41	P-glycoprotein	54,68	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form .
9746361	0	ATPase	4,10	P-glycoprotein	40,54	ATPase	P-glycoprotein	1769	5243	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	The ATPase and ATP-binding functions of P-glycoprotein -- modulation by interaction with defined phospholipids .
9914470	0	ATPase	95,101	P-glycoprotein	80,94	ATPase	P-glycoprotein	1769	5243	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Membrane fluidization by ether , other anesthetics , and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells .
11052626	0	ATPase	41,47	PKC_alpha	92,101	ATPase	PKC alpha	1769	5578	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Selective modulation of P-glycoprotein 's ATPase and anion efflux regulation activities with PKC_alpha and PKC_epsilon in Sf9 cells .
2940234	0	ATPase	38,44	PS3	75,78	ATPase	PS3	1769	448990	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Spectroscopic characterization of the ATPase of the thermophilic bacterium PS3 and its isolated subunits .
25547066	0	ATPase	47,53	SERCA1	64,70	ATPase	SERCA1	1769	487	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Rutin stimulates sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase activity -LRB- SERCA1 -RRB- and protects SERCA1 from peroxynitrite mediated injury .
10525666	0	ATPase	71,77	SERCA3	86,92	ATPase	SERCA3	1769	489	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence variants of the sarco -LRB- endo -RRB- plasmic reticulum Ca -LRB- 2 + -RRB- - transport ATPase 3 gene -LRB- SERCA3 -RRB- in Caucasian type II diabetic patients -LRB- UK Prospective Diabetes Study 48 -RRB- .
18208393	0	ATPase	90,96	Sso0909	40,47	ATPase	Sso0909	24869471	1455158(Tax:273057)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The Sulfolobus_solfataricus AAA protein Sso0909 , a homologue of the eukaryotic ESCRT Vps4 ATPase .
17562711	0	ATPase	36,42	UAP56	68,73	ATPase	UAP56	1769	7919	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Biochemical characterization of the ATPase and helicase activity of UAP56 , an essential pre-mRNA splicing and mRNA export factor .
18708638	0	ATPase	97,103	Vma13p	67,73	ATPase	Vma13p	1769	856148(Tax:4932)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of the N-terminal domain of subunit H -LRB- Vma13p -RRB- of the yeast vacuolar ATPase .
12058073	0	ATPase	6,12	androgen_receptor	56,73	ATPase	androgen receptor	1769	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Novel ATPase of SNF2-like protein family interacts with androgen_receptor and modulates androgen-dependent transcription .
19325002	0	ATPase	34,40	androgen_receptor	101,118	ATPase	androgen receptor	1769	367	Gene	Gene	Tat-binding_protein-1|appos|START_ENTITY enhances|nsubj|Tat-binding_protein-1 enhances|dobj|function function|compound|END_ENTITY	Tat-binding_protein-1 -LRB- TBP-1 -RRB- , an ATPase of 19S regulatory particles of the 26S proteasome , enhances androgen_receptor function in cooperation with TBP-1-interacting_protein / Hop2 .
2552440	0	ATPase	74,80	dATPase	82,89	ATPase	dATPase	36731(Tax:7227)	36731(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	An RNA polymerase II transcription factor has an associated DNA-dependent ATPase -LRB- dATPase -RRB- activity strongly stimulated by the TATA region of promoters .
19671661	0	ATPase	28,34	helicase	4,12	ATPase	helicase	1769	164045	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54 .
9840919	0	ATPase	49,55	helicase	64,72	ATPase	helicase	1769	164045	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Point mutations causing Bloom 's _ syndrome abolish ATPase and DNA helicase activities of the BLM protein .
11812147	0	ATPase	24,30	hsp90	49,54	ATPase	hsp90	1769	3320	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Stimulation of the weak ATPase activity of human hsp90 by a client protein .
17295899	0	ATPase	52,58	interleukin-1beta	72,89	ATPase	interleukin-1beta	1769	3553	Gene	Gene	isoform|nmod|START_ENTITY domain|nmod|isoform regulate|nsubj|domain regulate|dobj|production production|amod|END_ENTITY	The N-terminus domain of the a2 isoform of vacuolar ATPase can regulate interleukin-1beta production from mononuclear cells in co-culture with JEG-3 choriocarcinoma cells .
17509446	0	ATPase	67,73	interleukin-1beta	77,94	ATPase	interleukin-1beta	1769	3553	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Novel role for the N-terminus domain of the a2 isoform of vacuolar ATPase in interleukin-1beta production .
10090768	0	ATPase	103,109	myosin	20,26	ATPase	myosin	1769	79784	Gene	Gene	cycle|compound|START_ENTITY affects|nmod|cycle affects|nsubj|sequence sequence|nmod|loop loop|amod|END_ENTITY	The sequence of the myosin 50-20K loop affects Myosin 's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity .
11231583	0	ATPase	31,37	myosin	2,8	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY uncouples|dobj|activity uncouples|nsubj|mutation mutation|amod|END_ENTITY	A myosin II mutation uncouples ATPase activity from motility and shortens step size .
11278776	0	ATPase	87,93	myosin	4,10	ATPase	myosin	1769	79784	Gene	Gene	cycle|compound|START_ENTITY intact|nmod|cycle remains|xcomp|intact remains|nsubj|helix helix|amod|END_ENTITY	The myosin relay helix to converter interface remains intact throughout the actomyosin ATPase cycle .
11853967	0	ATPase	46,52	myosin	39,45	ATPase	myosin	1769	79784	Gene	Gene	START_ENTITY|nsubj|response response|nmod|END_ENTITY	Differential response of fast and slow myosin ATPase from skeletal muscle to F-actin and to phalloidin_F-actin .
124603	0	ATPase	48,54	myosin	41,47	ATPase	myosin	1769	79784	Gene	Gene	reaction|compound|START_ENTITY reaction|amod|END_ENTITY	-LSB- Study of the stationary kinetics of the myosin ATPase reaction in the presence of calcium -RSB- .
12547786	0	ATPase	23,29	myosin	92,98	ATPase	myosin	1769	79784	Gene	Gene	activation|compound|START_ENTITY activation|nmod|cycle cycle|nmod|END_ENTITY	Chemical decoupling of ATPase activation and force production from the contractile cycle in myosin by steric hindrance of lever-arm_movement .
127356	0	ATPase	29,35	myosin	8,14	ATPase	myosin	1769	79784	Gene	Gene	preparation|appos|START_ENTITY END_ENTITY|dep|preparation	Cardiac myosin : preparation , ATPase in chronic heart_hypertrophy .
129988	0	ATPase	34,40	myosin	78,84	ATPase	myosin	1769	79784	Gene	Gene	sensitivity|nmod|START_ENTITY sensitivity|dep|modification modification|nmod|substitution substitution|nmod|groups groups|amod|END_ENTITY	Calcium sensitivity of actomyosin ATPase : its modification by substitution of myosin sulfhydryl groups .
149560	0	ATPase	92,98	myosin	111,117	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The effect of mechanical stretching of the myosin rod component -LRB- fragment LMMMM S-2 -RRB- on the ATPase activity of myosin .
149560	0	ATPase	92,98	myosin	43,49	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY effect|nmod|activity effect|nmod|stretching stretching|nmod|component component|compound|END_ENTITY	The effect of mechanical stretching of the myosin rod component -LRB- fragment LMMMM S-2 -RRB- on the ATPase activity of myosin .
14965039	0	ATPase	17,23	myosin	24,30	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Effect of pH on ATPase myosin activity of different muscle types -RSB- .
20362584	0	ATPase	69,75	myosin	53,59	ATPase	myosin	36731(Tax:7227)	38001(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY Mutating|nsubj|activity Mutating|dobj|interface interface|nmod|END_ENTITY	Mutating the converter-relay interface of Drosophila myosin perturbs ATPase activity , actin motility , myofibril stability and flight ability .
2527847	0	ATPase	15,21	myosin	46,52	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Measurement of ATPase activity of immobilized myosin heads .
27061920	0	ATPase	4,10	myosin	24,30	ATPase	myosin	1769	79784	Gene	Gene	mechanism|amod|START_ENTITY mechanism|nmod|END_ENTITY	The ATPase mechanism of myosin and actomyosin .
2940240	0	ATPase	57,63	myosin	37,43	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY heads|nmod|activity heads|nsubj|Involvement Involvement|nmod|peptide peptide|nmod|END_ENTITY	Involvement of the 50-kDa peptide of myosin heads in the ATPase activity revealed by fluorescent modification with 4-fluoro-7-nitrobenz-2-oxa-1 ,3 - diazole .
2972697	0	ATPase	40,46	myosin	74,80	ATPase	myosin	1769	79784	Gene	Gene	reaction|compound|START_ENTITY steps|nmod|reaction END_ENTITY|nsubj|steps	Elementary steps of the actin-activated ATPase reaction of cardiac muscle myosin subfragment-1 .
3155516	0	ATPase	48,54	myosin	34,40	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY alters|dobj|activity alters|nsubj|Modification Modification|nmod|thiols thiols|nmod|END_ENTITY	Modification of thiols of gizzard myosin alters ATPase activity , stability of myosin filaments , and the 6-10 S conformational transition .
3155681	0	ATPase	64,70	myosin	39,45	ATPase	myosin	1769	79784	Gene	Gene	activity|compound|START_ENTITY Effect|nmod|activity Effect|nmod|structure structure|nmod|END_ENTITY	Effect of the filamentous structure of myosin on the actomyosin ATPase activity .
3160344	0	ATPase	38,44	myosin	31,37	ATPase	myosin	1769	79784	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of pancreatic islet myosin ATPase by ATP and actin .
4227924	0	ATPase	0,6	myosin	19,25	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	ATPase activity of myosin correlated with speed of muscle shortening .
6118361	0	ATPase	68,74	myosin	29,35	ATPase	myosin	1769	79784	Gene	Gene	activity|compound|START_ENTITY critical|nmod|activity critical|nsubj|region region|nmod|chain chain|amod|END_ENTITY	N-terminal region of gizzard myosin heavy chain is critical for the ATPase activity .
6184341	0	ATPase	46,52	myosin	39,45	ATPase	myosin	1769	79784	Gene	Gene	stains|compound|START_ENTITY stains|amod|END_ENTITY	Discrimination and consistency of five myosin ATPase stains in human normal_and_Duchenne_dystrophic_muscle .
6212085	0	ATPase	35,41	myosin	54,60	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	-LSB- Acridine orange inhibition of the ATPase activity of myosin and its fragments -RSB- .
6217171	0	ATPase	38,44	myosin	31,37	ATPase	myosin	1769	79784	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Relationship among fibre type , myosin ATPase activity and contractile properties .
6220012	0	ATPase	15,21	myosin	35,41	ATPase	myosin	1769	79784	Gene	Gene	START_ENTITY|nmod|minifilaments minifilaments|compound|END_ENTITY	The actomyosin ATPase of synthetic myosin minifilaments , filaments , and heavy meromyosin .
6240225	0	ATPase	37,43	myosin	84,90	ATPase	myosin	1769	79784	Gene	Gene	activity|compound|START_ENTITY activity|nmod|subfragment-1 subfragment-1|compound|END_ENTITY	Effect of mild heat treatment on the ATPase activity and proteolytic sensitivity of myosin subfragment-1 .
6447698	0	ATPase	75,81	myosin	68,74	ATPase	myosin	1769	79784	Gene	Gene	reaction|compound|START_ENTITY reaction|amod|END_ENTITY	The stereochemical course of phosphoric residue transfer during the myosin ATPase reaction .
8132717	0	ATPase	12,18	myosin	58,64	ATPase	myosin	1769	79784	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain .
8368268	0	ATPase	42,48	myosin	35,41	ATPase	myosin	481	79784	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Polylysine activates smooth muscle myosin ATPase activity via induction of a 10S to 6S transition .
8436225	0	ATPase	21,27	myosin	14,20	ATPase	myosin	1769	79784	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Inhibition of myosin ATPase activity by human myasthenia_gravis antibodies reactive with the acetylcholine receptor .
8994611	0	ATPase	0,6	myosin	19,25	ATPase	myosin	1769	79784	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	ATPase activity of myosin in hair bundles of the bullfrog 's sacculus .
9458041	0	ATPase	39,45	myosin	80,86	ATPase	myosin	1769	79784	Gene	Gene	observation|nmod|START_ENTITY observation|nmod|molecule molecule|compound|END_ENTITY	Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin .
9889810	0	ATPase	15,21	myosin	36,42	ATPase	myosin	1769	79784	Gene	Gene	activities|compound|START_ENTITY Measurement|nmod|activities Measurement|nmod|END_ENTITY	Measurement of ATPase activities of myosin at the level of tracks and single molecules .
10969013	0	ATPase	27,33	myosin_V	18,26	ATPase	myosin V	1769	4644	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	ADP inhibition of myosin_V ATPase activity .
19423668	0	ATPase	51,57	myosin_VIIA	70,81	ATPase	myosin VIIA	1769	4647	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	The tail binds to the head-neck domain , inhibiting ATPase activity of myosin_VIIA .
23678008	0	ATPase	32,38	p53	0,3	ATPase	p53	1769	7157	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	p53 suppresses BRCA2-stimulated ATPase and strand exchange functions of human RAD51 .
156639	0	ATPase	65,71	phospholipase_A2	11,27	ATPase	phospholipase A2	1769	151056	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phospholipase_A2 and albumin on the calcium-dependent ATPase and the lipid composition of sarcoplasmic membranes .
23233483	0	ATPase	4,10	reptin	23,29	ATPase	reptin	1769	10856	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The ATPase activity of reptin is required for its effects on tumor cell growth and viability_in_hepatocellular_carcinoma .
16431910	0	ATR	20,23	ATM	55,58	ATR	ATM	545	472	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|END_ENTITY	Rapid activation of ATR by ionizing radiation requires ATM and Mre11 .
17446169	0	ATR	60,63	ATM	108,111	ATR	ATM	398197(Tax:8355)	398148(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY activation|acl:relcl|occurs occurs|nmod|END_ENTITY	Ataxia-telangiectasia_mutated -LRB- ATM -RRB- - dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM .
17446169	0	ATR	60,63	ATM	31,34	ATR	ATM	398197(Tax:8355)	398148(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY Ataxia-telangiectasia_mutated|dep|activation Ataxia-telangiectasia_mutated|appos|END_ENTITY	Ataxia-telangiectasia_mutated -LRB- ATM -RRB- - dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM .
17478428	0	ATR	78,81	ATM	55,58	ATR	ATM	545	472	Gene	Gene	ATM-Rad3-related|dep|START_ENTITY substrates|amod|ATM-Rad3-related substrates|appos|END_ENTITY	A proteomic analysis of ataxia_telangiectasia-mutated -LRB- ATM -RRB- / ATM-Rad3-related -LRB- ATR -RRB- substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints .
18344416	0	ATR	22,25	ATM	121,124	ATR	ATM	545	472	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Differential roles of ATR and ATM in p53 , Chk1 , and histone_H2AX phosphorylation in response to hyperoxia : ATR-dependent ATM activation .
18757420	0	ATR	23,26	ATM	0,3	ATR	ATM	545	472	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	ATM acts downstream of ATR in the DNA damage response signaling of bystander cells .
20140190	0	ATR	39,42	ATM	88,91	ATR	ATM	545	472	Gene	Gene	Rad3|appos|START_ENTITY role|nmod|Rad3 role|dep|Rad26 Rad26|amod|complex complex|nmod|recruitment recruitment|nmod|Tel1 Tel1|appos|END_ENTITY	A kinase-independent role for the Rad3 -LRB- ATR -RRB- - Rad26 -LRB- ATRIP -RRB- complex in recruitment of Tel1 -LRB- ATM -RRB- to telomeres in fission_yeast .
21490603	0	ATR	78,81	ATM	21,24	ATR	ATM	545	472	Gene	Gene	inhibition|nmod|START_ENTITY Selective|nmod|inhibition Selective|dobj|killing killing|nmod|cells cells|amod|END_ENTITY	Selective killing of ATM - or p53-deficient cancer cells through inhibition of ATR .
25232030	0	ATR	58,61	ATM	111,114	ATR	ATM	545	472	Gene	Gene	Treatment|compound|START_ENTITY Sensitivity|nmod|Treatment Reveals|dobj|Sensitivity Reveals|nmod|Loss-of-function Loss-of-function|compound|END_ENTITY	A Synthetic Lethal Screen Reveals Enhanced Sensitivity to ATR Inhibitor Treatment in Mantle_Cell_Lymphoma with ATM Loss-of-function .
25497328	0	ATR	77,80	ATM	144,147	ATR	ATM	545	472	Gene	Gene	START_ENTITY|nmod|function function|compound|END_ENTITY	The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function .
16186122	0	ATR	108,111	ATRIP	99,104	ATR	ATRIP	398197(Tax:8355)	496388(Tax:8355)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
18519640	0	ATR	17,20	ATRIP	29,34	ATR	ATRIP	545	84126	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain .
20048340	0	ATR	22,25	CDC6	0,4	ATR	CDC6	398197(Tax:8355)	403388(Tax:8355)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells .
22357613	0	ATR	0,3	CTC1	20,24	ATR	CTC1	834082(Tax:3702)	826554(Tax:3702)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis .
19633697	0	ATR	21,24	Cdc5L	0,5	ATR	Cdc5L	545	988	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint .
23029527	0	ATR	18,21	Cdt2	37,41	ATR	Cdt2	545	51514	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Checkpoint kinase ATR phosphorylates Cdt2 , a substrate receptor of CRL4 ubiquitin ligase , and promotes the degradation of Cdt1 following UV irradiation .
15190204	0	ATR	0,3	Chk1	53,57	ATR	Chk1	545	1111	Gene	Gene	regulate|advmod|START_ENTITY regulate|dobj|END_ENTITY	ATR , Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage .
16186122	0	ATR	108,111	Chk1	19,23	ATR	Chk1	398197(Tax:8355)	398191(Tax:8355)	Gene	Gene	binding|nmod|START_ENTITY requires|dobj|binding requires|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
16186122	0	ATR	50,53	Chk1	19,23	ATR	Chk1	398197(Tax:8355)	398191(Tax:8355)	Gene	Gene	ATM|appos|START_ENTITY END_ENTITY|nmod|ATM	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
16880517	0	ATR	48,51	Chk1	70,74	ATR	Chk1	545	1111	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|amod|END_ENTITY	Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation .
17210576	0	ATR	60,63	Chk1	83,87	ATR	Chk1	545	1111	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Phosphatase_type_2A-dependent and - independent pathways for ATR phosphorylation of Chk1 .
19828454	0	ATR	72,75	Chk1	60,64	ATR	Chk1	545	1111	Gene	Gene	checkpoint|compound|START_ENTITY END_ENTITY|nmod|checkpoint	Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR -LRB- ataxia_telangiectasia-mutated and rad3-related -RRB- checkpoint kinase .
20233725	0	ATR	73,76	Chk1	49,53	ATR	Chk1	545	1111	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress .
21502314	0	ATR	175,178	Chk1	220,224	ATR	Chk1	545	1111	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|checkpoint_kinase_1 checkpoint_kinase_1|appos|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
23733185	0	ATR	131,134	Chk1	157,161	ATR	Chk1	545	1111	Gene	Gene	checkpoint_kinase_1|appos|START_ENTITY arrest|nmod|checkpoint_kinase_1 arrest|appos|END_ENTITY	4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia_telangiectasia mutated and Rad3-related protein -LRB- ATR -RRB- / checkpoint_kinase_1 -LRB- Chk1 -RRB- signaling pathway .
15190204	0	ATR	0,3	Claspin	5,12	ATR	Claspin	545	63967	Gene	Gene	regulate|advmod|START_ENTITY regulate|nsubj|END_ENTITY	ATR , Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage .
17483406	0	ATR	59,62	DNA_polymerase_alpha	9,29	ATR	DNA polymerase alpha	32608(Tax:7227)	42553(Tax:7227)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Reducing DNA_polymerase_alpha in the absence of Drosophila ATR leads to P53-dependent apoptosis and developmental_defects .
22922797	0	ATR	19,22	Dicer	44,49	ATR	Dicer	545	23405	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	miR-3928 activates ATR pathway by targeting Dicer .
18480432	0	ATR	22,25	E1B-AP5	11,18	ATR	E1B-AP5	545	11100	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	A role for E1B-AP5 in ATR signaling pathways during adenovirus_infection .
20060399	0	ATR	0,3	FRA3B	54,59	ATR	FRA3B	545	2272	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment .
17035231	0	ATR	39,42	RPA2	0,4	ATR	RPA2	545	6118	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint .
26854234	0	ATR	36,39	SIRT2	23,28	ATR	SIRT2	545	22933	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA .
23873943	0	ATR	0,3	SMARCAL1	19,27	ATR	SMARCAL1	545	50485	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	ATR phosphorylates SMARCAL1 to prevent replication fork collapse .
18519633	0	ATR	44,47	TopBP1	18,24	ATR	TopBP1	545	11073	Gene	Gene	goes|nmod|START_ENTITY goes|nsubj|END_ENTITY	How ATR turns on : TopBP1 goes on ATRIP with ATR .
18519640	0	ATR	17,20	TopBP1	0,6	ATR	TopBP1	545	11073	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain .
20802463	0	ATR	0,3	WRN	33,36	ATR	WRN	545	7486	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery .
12640452	0	ATR	92,95	ataxia-telangiectasia_and_Rad3-related_protein	44,90	ATR	ataxia-telangiectasia and Rad3-related protein	545	545	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	A splicing mutation affecting expression of ataxia-telangiectasia_and_Rad3-related_protein -LRB- ATR -RRB- results in Seckel_syndrome .
21502314	0	ATR	175,178	ataxia-telangiectasia_mutated_and_RAD3-related	127,173	ATR	ataxia-telangiectasia mutated and RAD3-related	545	545	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
25301947	0	ATR	190,193	ataxia_telangiectasia-mutated_and_Rad3-related	142,188	ATR	ataxia telangiectasia-mutated and Rad3-related	545	545	Gene	Gene	Signaling|appos|START_ENTITY Signaling|amod|END_ENTITY	Phosphorylation of the BRCA1 C terminus -LRB- BRCT -RRB- repeat inhibitor of hTERT -LRB- BRIT1 -RRB- protein coordinates TopBP1 protein recruitment and amplifies ataxia_telangiectasia-mutated_and_Rad3-related -LRB- ATR -RRB- Signaling .
17526493	0	ATR	122,125	ataxia_telangiectasia_mutated	66,95	ATR	ataxia telangiectasia mutated	545	472	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia_telangiectasia_mutated and Rad3-related protein -LRB- ATR -RRB- to regulate the S-phase checkpoint following UV treatment .
20103595	0	ATR	166,169	ataxia_telangiectasia_mutated_and_Rad3-related	118,164	ATR	ataxia telangiectasia mutated and Rad3-related	545	545	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3 ' - untranslated region of ataxia_telangiectasia_mutated_and_Rad3-related _ -LRB- ATR -RRB- transcript .
21502314	0	ATR	175,178	checkpoint_kinase_1	199,218	ATR	checkpoint kinase 1	545	1111	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
10435622	0	ATR	42,45	p53	88,91	ATR	p53	545	7157	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53 .
11711532	0	ATR	0,3	p53	24,27	ATR	p53	545	7157	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint .
14654783	0	ATR	43,46	p53	65,68	ATR	p53	545	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|attenuation attenuation|nmod|export export|compound|END_ENTITY	Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export .
18032786	0	ATR	153,156	p53	127,130	ATR	p53	545	7157	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The increase of cell-membranous phosphatidylcholines containing polyunsaturated_fatty_acid residues induces phosphorylation of p53 through activation of ATR .
18344416	0	ATR	22,25	p53	37,40	ATR	p53	545	7157	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles of ATR and ATM in p53 , Chk1 , and histone_H2AX phosphorylation in response to hyperoxia : ATR-dependent ATM activation .
18606816	0	ATR	77,80	p53	109,112	ATR	p53	545	7157	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|compound|END_ENTITY	Hepatitis_B_virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis .
21258400	0	ATR	0,3	p53	39,42	ATR	p53	545	7157	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|resistance resistance|nmod|manner manner|compound|END_ENTITY	ATR mediates cisplatin resistance in a p53 genotype-specific manner .
21643554	0	ATR	131,134	p53	37,40	ATR	p53	545	7157	Gene	Gene	checkpoint|compound|START_ENTITY independent|nmod|checkpoint independent|nsubj|responses responses|nmod|cells cells|nummod|END_ENTITY	Differential DNA damage responses in p53 proficient and deficient cells : cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53-deficient_lung_cancer cells .
9925639	0	ATR	11,14	p53	60,63	ATR	p53	545	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for ATR in the DNA damage-induced phosphorylation of p53 .
16186122	0	ATRIP	99,104	ATR	108,111	ATRIP	ATR	496388(Tax:8355)	398197(Tax:8355)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
18519640	0	ATRIP	29,34	ATR	17,20	ATRIP	ATR	84126	545	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain .
16186122	0	ATRIP	99,104	Chk1	19,23	ATRIP	Chk1	496388(Tax:8355)	398191(Tax:8355)	Gene	Gene	binding|nmod|START_ENTITY requires|dobj|binding requires|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
18519633	0	ATRIP	33,38	TopBP1	18,24	ATRIP	TopBP1	84126	11073	Gene	Gene	goes|nmod|START_ENTITY goes|nsubj|END_ENTITY	How ATR turns on : TopBP1 goes on ATRIP with ATR .
18519640	0	ATRIP	29,34	TopBP1	0,6	ATRIP	TopBP1	84126	11073	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain .
20865721	0	ATRX	26,30	chromatin-remodeling_factor	39,66	ATRX	chromatin-remodeling factor	22589(Tax:10090)	192195(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|appos|END_ENTITY	Reduced expression of the ATRX gene , a chromatin-remodeling_factor , causes hippocampal_dysfunction in mice .
22240898	0	ATRX	0,4	huntingtin	25,35	ATRX	huntingtin	43080(Tax:7227)	43392(Tax:7227)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington 's _ disease .
26997151	0	ATX	77,80	Autotaxin	66,75	ATX	Autotaxin	5168	5168	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Computer Aided Drug Design Approaches for Identification of Novel Autotaxin -LRB- ATX -RRB- Inhibitors .
12699618	0	ATX-1	0,5	trithorax	33,42	ATX-1	trithorax	842940(Tax:3702)	41737(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	ATX-1 , an Arabidopsis homolog of trithorax , activates flower homeotic genes .
10982193	0	ATX1	30,34	HAH1	46,50	ATX1	HAH1	475	475	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Physical mapping of the human ATX1 homologue -LRB- HAH1 -RRB- to the critical region of the 5q - syndrome within 5q32 , and immediately adjacent to the SPARC gene .
21294677	0	ATX3	41,45	ataxin-3	31,39	ATX3	ataxin-3	4287	4287	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Allele-selective inhibition of ataxin-3 -LRB- ATX3 -RRB- expression by antisense oligomers and duplex RNAs .
18301861	0	ATXN-1	77,83	ataxin-1	67,75	ATXN-1	ataxin-1	6310	6310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Direct and accurate measurement of CAG repeat configuration in the ataxin-1 -LRB- ATXN-1 -RRB- gene by `` dual-fluorescence labeled PCR-restriction fragment length analysis '' .
21835928	0	ATXN1	27,32	ataxin-1	18,26	ATXN1	ataxin-1	6310	6310	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	14-3-3 Binding to ataxin-1 -LRB- ATXN1 -RRB- regulates its dephosphorylation at Ser-776 and transport to the nucleus .
22914732	0	ATXN2	33,38	ETS1	0,4	ATXN2	ETS1	20239(Tax:10090)	23871(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ETS1 regulates the expression of ATXN2 .
20016785	0	ATXN2	55,60	spinocerebellar_ataxia_type_2	24,53	ATXN2	spinocerebellar ataxia type 2	6311	6311	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variance in the spinocerebellar_ataxia_type_2 -LRB- ATXN2 -RRB- gene in children with severe early onset obesity .
19935829	0	ATXN3	49,54	Machado-Joseph_Disease	20,42	ATXN3	Machado-Joseph Disease	4287	4287	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The -LRB- CAG -RRB- n tract of Machado-Joseph_Disease gene -LRB- ATXN3 -RRB- : a comparison between DNA and mRNA in patients and controls .
2465218	0	AT_III	29,35	antithrombin_III	11,27	AT III	antithrombin III	462	462	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes of antithrombin_III -LRB- AT_III -RRB- in AT_III_deficient patients during long-term anticoagulant treatment .
25908445	0	AUF-1	136,141	superoxide_dismutase_1	4,26	AUF-1	superoxide dismutase 1	3184	6647	Gene	Gene	involvement|nmod|START_ENTITY expression|dep|involvement expression|amod|END_ENTITY	The superoxide_dismutase_1 3 ` UTR maintains high expression of the SOD1 gene in cancer cells : The involvement of the RNA-binding_protein AUF-1 .
26253535	0	AUF1	0,4	Argonaute_2	32,43	AUF1	Argonaute 2	3184	27161	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	AUF1 promotes let-7b loading on Argonaute_2 .
23066106	0	AUF1	20,24	Dicer	35,40	AUF1	Dicer	3184	23405	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	RNA-binding_protein AUF1 represses Dicer expression .
20498276	0	AUF1	9,13	HuR	0,3	AUF1	HuR	3184	1994	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay .
18844578	0	AUF1	0,4	IL10	54,58	AUF1	IL10	3184	3586	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes .
21135123	0	AUF1	20,24	IL10	62,66	AUF1	IL10	3184	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	RNA-binding_protein AUF1 regulates lipopolysaccharide-induced IL10 expression by activating IkappaB kinase complex in monocytes .
16834569	0	AUF1	26,30	PABP	74,78	AUF1	PABP	3184	26986	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The ARE-associated factor AUF1 binds poly -LRB- A -RRB- in vitro in competition with PABP .
18789946	0	AUF1	0,4	angiotensin_II	23,37	AUF1	angiotensin II	3184	183	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	AUF1 is upregulated by angiotensin_II to destabilize cardiac Kv4 .3 channel mRNA .
18202450	0	AUF1	42,46	heterogeneous_nuclear_ribonucleoprotein_L	62,103	AUF1	heterogeneous nuclear ribonucleoprotein L	3184	3191	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_D / AUF1 interacts with heterogeneous_nuclear_ribonucleoprotein_L .
19074427	0	AUF1	120,124	inducible_nitric-oxide_synthase	28,59	AUF1	inducible nitric-oxide synthase	3184	4843	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Similar regulation of human inducible_nitric-oxide_synthase expression by different isoforms of the RNA-binding protein AUF1 .
20489206	0	AUF1	156,160	p42	152,155	AUF1	p42	3184	2038	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Leukotriene_B -LRB- 4 -RRB- BLT receptor signaling regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of Ras/Raf/ERK / p42 AUF1 pathway .
20716519	0	AUF1	0,4	p42	5,8	AUF1	p42	3184	2038	Gene	Gene	isoform|nummod|START_ENTITY isoform|amod|END_ENTITY	AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay .
10702317	0	AUF1	18,22	parathyroid_hormone	28,47	AUF1	parathyroid hormone	79256(Tax:10116)	24694(Tax:10116)	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Identification of AUF1 as a parathyroid_hormone mRNA 3 ' - untranslated region-binding protein that determines parathyroid_hormone mRNA stability .
21857022	0	AUP1	43,47	ancient_ubiquitous_protein_1	13,41	AUP1	ancient ubiquitous protein 1	550	550	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Dual role of ancient_ubiquitous_protein_1 -LRB- AUP1 -RRB- in lipid droplet accumulation and endoplasmic reticulum -LRB- ER -RRB- protein quality control .
23499911	0	AURKA	126,131	Akt1	109,113	AURKA	Akt1	6790	207	Gene	Gene	activation|compound|START_ENTITY mediated|nmod|activation END_ENTITY|acl|mediated	AEG-1 overexpression is essential for maintenance of malignant state in human AML cells via up-regulation of Akt1 mediated by AURKA activation .
22621899	0	AURKA	42,47	Aurora-A_kinase	25,40	AURKA	Aurora-A kinase	6790	6790	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Calmodulin activation of Aurora-A_kinase -LRB- AURKA -RRB- is required during ciliary disassembly and in mitosis .
24104968	0	AURKA	17,22	Aurora_kinase_A	0,15	AURKA	Aurora kinase A	6790	6790	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Aurora_kinase_A -LRB- AURKA -RRB- expression in colorectal_cancer_liver_metastasis is associated with poor prognosis .
25900902	0	AURKA	37,42	Aurora_kinase_A	20,35	AURKA	Aurora kinase A	6790	6790	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Prognostic value of Aurora_kinase_A -LRB- AURKA -RRB- expression among solid tumor patients : a systematic review and meta-analysis .
24240108	0	AURKA	19,24	HDM2	0,4	AURKA	HDM2	6790	4193	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	HDM2 regulation by AURKA promotes cell survival in gastric_cancer .
25395580	0	AURKA	22,27	INPP5E	0,6	AURKA	INPP5E	6790	56623	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	INPP5E interacts with AURKA , linking phosphoinositide signalling to primary cilium stability .
25512615	0	AURKA	21,26	miR-25	46,52	AURKA	miR-25	6790	407014	Gene	Gene	Overexpression|compound|START_ENTITY Overexpression|nmod|END_ENTITY	p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small_Cell_Neuroendocrine_Carcinoma .
19447663	0	AURKC	30,35	aurora_kinase_C	13,28	AURKC	aurora kinase C	6795	6795	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	-LSB- Function of aurora_kinase_C -LRB- AURKC -RRB- in human reproduction -RSB- .
21353399	0	AURKC	114,119	aurora_kinase_C	92,107	AURKC	aurora kinase C	6795	6795	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Confirmation of the high prevalence in Morocco of the homozygous mutation c. 144delC in the aurora_kinase_C gene -LRB- AURKC -RRB- in the teratozoospermia with large-headed spermatozoa -RSB- .
25398668	0	AUTS2	76,81	Autism_Susceptibility_Candidate_2	41,74	AUTS2	Autism Susceptibility Candidate 2	26053	26053	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	The Evidence for the Contribution of the Autism_Susceptibility_Candidate_2 -LRB- AUTS2 -RRB- Gene in Heroin Dependence Susceptibility .
26059335	0	AUX1	38,42	LBD16	0,5	AUX1	LBD16	818390(Tax:3702)	818843(Tax:3702)	Gene	Gene	Downstream|nmod|START_ENTITY Downstream|compound|END_ENTITY	LBD16 and LBD18 Act Downstream of the AUX1 and LAX3 Auxin Influx Carriers to Control Lateral Root Development in Arabidopsis_thaliana .
2132633	0	AVP	64,67	vasopressin	51,62	AVP	vasopressin	551	551	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Water immersion -LRB- WI -RRB- induced alterations of plasma vasopressin -LRB- AVP -RRB- levels in patients with noninflammatory acute_renal_failure -LRB- NARF -RRB- and in patients with chronic_renal_failure -LRB- CRF -RRB- .
2138551	0	AVP	19,22	vasopressin	6,17	AVP	vasopressin	551	551	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum vasopressin -LRB- AVP -RRB- levels in polyuric brain-dead organ donors .
24002911	0	AVP1	119,123	Arabidopsis_vacuolar_pyrophosphatase	81,117	AVP1	Arabidopsis vacuolar pyrophosphatase	838138(Tax:3702)	838138(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic improvement of sugarcane for drought and salinity stress tolerance using Arabidopsis_vacuolar_pyrophosphatase -LRB- AVP1 -RRB- gene .
25016245	0	AVPR1A	58,64	arginine_vasopressin_receptor_1A	24,56	AVPR1A	arginine vasopressin receptor 1A	552	552	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between the arginine_vasopressin_receptor_1A -LRB- AVPR1A -RRB- gene and preschoolers ' executive functioning .
18655900	0	AVPR1a	67,73	OXTR	102,106	AVPR1a	OXTR	552	5021	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Molecular genetic studies of the arginine_vasopressin 1a receptor -LRB- AVPR1a -RRB- and the oxytocin_receptor -LRB- OXTR -RRB- in human behaviour : from autism to altruism with some notes in between .
26131744	0	AVPR2	46,51	V2_vasopressin_receptor	16,39	AVPR2	V2 vasopressin receptor	554	554	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation in the V2_vasopressin_receptor gene , AVPR2 , causes nephrogenic_syndrome of inappropriate diuresis .
21810480	0	AWP1	0,4	tumor_necrosis_factor_receptor-associated_factor_2	14,64	AWP1	tumor necrosis factor receptor-associated factor 2	54469	7186	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	AWP1 binds to tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- and is involved in TRAF2-mediated nuclear factor-kappaB signaling .
21057547	0	AXIN	0,4	promyelocytic_leukemia_protein	42,72	AXIN	promyelocytic leukemia protein	8312	5371	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	AXIN is an essential co-activator for the promyelocytic_leukemia_protein in p53 activation .
10700176	0	AXIN1	0,5	AXIN1	115,120	AXIN1	AXIN1	8312	8312	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	AXIN1 mutations in hepatocellular_carcinomas , and growth suppression in cancer cells by virus-mediated transfer of AXIN1 .
10700176	0	AXIN1	115,120	AXIN1	0,5	AXIN1	AXIN1	8312	8312	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	AXIN1 mutations in hepatocellular_carcinomas , and growth suppression in cancer cells by virus-mediated transfer of AXIN1 .
24299953	0	AXIN2	8,13	MYC	24,27	AXIN2	MYC	8313	4609	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Nuclear AXIN2 represses MYC gene expression .
23117882	0	AXL	18,21	ABL	0,3	AXL	ABL	558	25	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	ABL regulation by AXL promotes cisplatin resistance in esophageal_cancer .
25520864	0	AXL	83,86	miR-199a-3p	0,11	AXL	miR-199a-3p	558	406977	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-199a-3p negatively regulates the progression of osteosarcoma through targeting AXL .
21555911	0	AXL	64,67	receptor_tyrosine_kinase	68,92	AXL	receptor tyrosine kinase	558	5979	Gene	Gene	methylation|nmod|START_ENTITY environment|nmod|methylation Heritability|nmod|environment END_ENTITY|nsubj|Heritability	Heritability and role for the environment in DNA methylation in AXL receptor_tyrosine_kinase .
17442564	0	AXOR12	57,63	metastin	14,22	AXOR12	metastin	84634	3814	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of metastin and a G-protein-coupled receptor -LRB- AXOR12 -RRB- in epithelial_ovarian_cancer .
24550735	0	AZI1	33,37	BBS4	53,57	AZI1	BBS4	563066(Tax:7955)	768303(Tax:7955)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome .
26963840	0	AZIN2	40,45	ODC_Antizyme_Inhibitor_2	14,38	AZIN2	ODC Antizyme Inhibitor 2	113451	113451	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ODC_Antizyme_Inhibitor_2 -LRB- AZIN2 -RRB- in Human Secretory Cells and Tissues .
11113970	0	AZR1	18,22	YGR224w	33,40	AZR1	YGR224w	853139(Tax:4932)	853139(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY Expression|nmod|gene Expression|appos|END_ENTITY	Expression of the AZR1 gene -LRB- ORF YGR224w -RRB- , encoding a plasma membrane transporter of the major facilitator superfamily , is required for adaptation to acetic_acid and resistance to azoles in Saccharomyces_cerevisiae .
23337484	0	A_Proliferation-Inducing_Ligand	24,55	APRIL	57,62	A Proliferation-Inducing Ligand	APRIL	8741	8741	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of A_Proliferation-Inducing_Ligand -LRB- APRIL -RRB- are elevated in sepsis and predict mortality in critically ill patients .
8554610	0	A_beta	75,81	C1Q	42,45	A beta	C1Q	351	712	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Multivalent binding of complement protein C1Q to the amyloid beta-peptide -LRB- A_beta -RRB- promotes the nucleation phase of A_beta aggregation .
8187553	0	A_beta	78,84	Calna2	95,101	A beta	Calna2	54226(Tax:10116)	24675(Tax:10116)	Gene	Gene	subunits|compound|START_ENTITY subunits|appos|END_ENTITY	Chromosomal assignments of the genes for the calcineurin A alpha -LRB- Calna1 -RRB- and A_beta subunits -LRB- Calna2 -RRB- in the rat .
12270697	0	A_beta	69,75	FPR2	17,21	A beta	FPR2	11820(Tax:10090)	14289(Tax:10090)	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of FPR2 , a chemotactic receptor for amyloid beta 1-42 -LRB- A_beta 42 -RRB- , in murine microglial cells by TNF_alpha .
7568089	0	A_beta	118,124	NACP	0,4	A beta	NACP	351	6622	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer_disease amyloid , binds A_beta and stimulates A_beta aggregation .
7568089	0	A_beta	64,70	NACP	0,4	A beta	NACP	351	6622	Gene	Gene	component|appos|START_ENTITY protein|nmod|component END_ENTITY|appos|protein	NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer_disease amyloid , binds A_beta and stimulates A_beta aggregation .
9462843	0	A_beta	179,185	NACP	24,28	A beta	NACP	351	6622	Gene	Gene	fragment|compound|START_ENTITY presence|nmod|fragment observed|nmod|presence observed|nsubj|Self-oligomerization Self-oligomerization|nmod|END_ENTITY	Self-oligomerization of NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer 's _ disease amyloid , observed in the presence of a C-terminal A_beta fragment -LRB- residues 25-35 -RRB- .
9462843	0	A_beta	88,94	NACP	24,28	A beta	NACP	351	6622	Gene	Gene	component|appos|START_ENTITY protein|nmod|component Self-oligomerization|appos|protein Self-oligomerization|nmod|END_ENTITY	Self-oligomerization of NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer 's _ disease amyloid , observed in the presence of a C-terminal A_beta fragment -LRB- residues 25-35 -RRB- .
7575468	0	A_beta	53,59	amyloid_precursor_protein	24,49	A beta	amyloid precursor protein	351	351	Gene	Gene	peptides|compound|START_ENTITY END_ENTITY|nmod|peptides	Lysosomal processing of amyloid_precursor_protein to A_beta peptides : a distinct role for cathepsin_S .
17385715	0	A_beta	102,108	caspase-3	39,48	A beta	caspase-3	351	836	Gene	Gene	forms|nmod|START_ENTITY forms|amod|END_ENTITY	Differential binding and activation of caspase-3 in cultured hippocampal neurons by assembly forms of A_beta 1-42 .
12212791	0	A_beta	87,93	low-density_lipoprotein_receptor-related_protein	16,64	A beta	low-density lipoprotein receptor-related protein	351	100754427	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	The role of the low-density_lipoprotein_receptor-related_protein -LRB- LRP1 -RRB- in Alzheimer 's A_beta generation : development of a cell-based model system .
12753080	0	A_beta	11,17	matrix_metalloproteinase-2	59,85	A beta	matrix metalloproteinase-2	351	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Pathogenic A_beta induces the expression and activation of matrix_metalloproteinase-2 in human cerebrovascular smooth muscle cells .
25846075	0	A_disintegrin_and_metalloprotease_17	102,138	interleukin-6_receptor	68,90	A disintegrin and metalloprotease 17	interleukin-6 receptor	6868	3570	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Secreted_Frizzled-related_protein_3 -LRB- sFRP3 -RRB- - mediated suppression of interleukin-6_receptor release by A_disintegrin_and_metalloprotease_17 -LRB- ADAM17 -RRB- is abrogated in the osteoarthritis-associated rare double variant of sFRP3 .
25846075	0	A_disintegrin_and_metalloprotease_17	102,138	interleukin-6_receptor	68,90	A disintegrin and metalloprotease 17	interleukin-6 receptor	6868	3570	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Secreted_Frizzled-related_protein_3 -LRB- sFRP3 -RRB- - mediated suppression of interleukin-6_receptor release by A_disintegrin_and_metalloprotease_17 -LRB- ADAM17 -RRB- is abrogated in the osteoarthritis-associated rare double variant of sFRP3 .
23639813	0	A_disintegrin_and_metalloproteinase_17	0,38	TNF	49,52	A disintegrin and metalloproteinase 17	TNF	11491(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	A_disintegrin_and_metalloproteinase_17 regulates TNF and TNFR1 levels in inflammation and liver_regeneration in mice .
24412389	0	A_disintegrin_and_metalloproteinase_17	0,38	angiotensin_II	109,123	A disintegrin and metalloproteinase 17	angiotensin II	6868	183	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	A_disintegrin_and_metalloproteinase_17 -LRB- ADAM17 -RRB- mediates epidermal_growth_factor_receptor transactivation by angiotensin_II on hepatic stellate cells .
24412389	0	A_disintegrin_and_metalloproteinase_17	0,38	epidermal_growth_factor_receptor	57,89	A disintegrin and metalloproteinase 17	epidermal growth factor receptor	6868	1956	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|transactivation transactivation|compound|END_ENTITY	A_disintegrin_and_metalloproteinase_17 -LRB- ADAM17 -RRB- mediates epidermal_growth_factor_receptor transactivation by angiotensin_II on hepatic stellate cells .
23857158	0	A_disintegrin_and_metalloproteinase_9	24,61	ADAM9	63,68	A disintegrin and metalloproteinase 9	ADAM9	8754	8754	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Serum concentrations of A_disintegrin_and_metalloproteinase_9 -LRB- ADAM9 -RRB- mRNA as a promising novel marker for the detection of pulmonary_sarcoidosis .
26563155	0	A_disintegrin_and_metalloproteinase_with_thrombospondin_motif_1	0,63	ADAMTS1	65,72	A disintegrin and metalloproteinase with thrombospondin motif 1	ADAMTS1	9510	9510	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A_disintegrin_and_metalloproteinase_with_thrombospondin_motif_1 -LRB- ADAMTS1 -RRB- expression increases in acute aortic dissection .
22052684	0	A_kinase_anchor_protein_12	22,48	AKAP12	50,56	A kinase anchor protein 12	AKAP12	9590	9590	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the A_kinase_anchor_protein_12 -LRB- AKAP12 -RRB- gene as a candidate tumor suppressor of hepatocellular carcinoma .
12496250	0	A_kinase_anchoring_protein	93,119	Parathyroid_hormone	0,19	A kinase anchoring protein	Parathyroid hormone	11214	5741	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|regulation regulation|amod|END_ENTITY	Parathyroid_hormone regulation of type II sodium-phosphate cotransporters is dependent on an A_kinase_anchoring_protein .
21595749	0	A_proliferation-inducing_ligand	0,31	APRIL	33,38	A proliferation-inducing ligand	APRIL	8741	8741	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	A_proliferation-inducing_ligand -LRB- APRIL -RRB- serum levels predict time to first treatment in patients affected by B-cell_chronic_lymphocytic_leukemia .
15522812	0	Aanat	152,157	arylalkylamine_N-acetyltransferase	116,150	Aanat	arylalkylamine N-acetyltransferase	15	15	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Convergent evolution of strigiform and caprimulgiform dark-activity is supported by phylogenetic analysis using the arylalkylamine_N-acetyltransferase -LRB- Aanat -RRB- gene .
26866375	0	AarF_Domain_Containing_Kinase_3	0,31	ADCK3	33,38	AarF Domain Containing Kinase 3	ADCK3	56997	56997	Gene	Gene	Cells|amod|START_ENTITY Cells|appos|END_ENTITY	AarF_Domain_Containing_Kinase_3 -LRB- ADCK3 -RRB- Mutant Cells Display Signs of Oxidative Stress , Defects_in_Mitochondrial_Homeostasis_and_Lysosomal_Accumulation .
15809997	0	Aarskog-Scott_syndrome	84,106	FGD1	122,126	Aarskog-Scott syndrome	FGD1	2245	2245	Gene	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	Attention-deficit/hyperactivity _ disorder -LRB- ADHD -RRB- and variable clinical expression of Aarskog-Scott_syndrome due to a novel FGD1 gene mutation -LRB- R408Q -RRB- .
23531501	0	AbPP	34,38	Fe65	39,43	AbPP	Fe65	54226(Tax:10116)	29722(Tax:10116)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of a novel complex AbPP : Fe65 : PP1 that regulates AbPP Thr668 phosphorylation levels .
25697841	0	AbPP	37,41	Myelin_Basic_Protein	0,20	AbPP	Myelin Basic Protein	351	4155	Gene	Gene	Associates|nmod|START_ENTITY Associates|compound|END_ENTITY	Myelin_Basic_Protein Associates with AbPP , Ab1-42 , and Amyloid_Plaques in Cortex of Alzheimer 's _ Disease Brain .
22495347	0	AbPP	82,86	PSEN1	91,96	AbPP	PSEN1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Chronic allopregnanolone treatment accelerates Alzheimer 's _ disease development in AbPP -LRB- Swe -RRB- PSEN1 -LRB- / \ E9 -RRB- mice .
23340159	0	Abcb1	45,50	Constitutive_androstane_receptor	0,32	Abcb1	Constitutive androstane receptor	5243	9970	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Constitutive_androstane_receptor upregulates Abcb1 and Abcg2 at the blood-brain barrier after CITCO activation .
17845218	0	Abcc1	21,26	Abcc6	39,44	Abcc1	Abcc6	17250(Tax:10090)	27421(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Targeted ablation of Abcc1 or Abcc3 in Abcc6 -LRB- - / - -RRB- mice does not modify the ectopic mineralization process .
12145812	0	Abcc2	79,84	Mrp2	73,77	Abcc2	Mrp2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Organ-specific alterations in RAR_alpha : RXR_alpha abundance regulate rat Mrp2 -LRB- Abcc2 -RRB- expression in obstructive cholestasis .
18088505	0	Abcc2	21,26	Mrp2	15,19	Abcc2	Mrp2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Mrp2 -LRB- Abcc2 -RRB- in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver .
16537972	0	Abcc2	74,79	multidrug_resistance-associated_protein_2	31,72	Abcc2	multidrug resistance-associated protein 2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Hormonal regulation of hepatic multidrug_resistance-associated_protein_2 -LRB- Abcc2 -RRB- primarily involves the pattern of growth_hormone secretion .
12837754	0	Abcc3	70,75	Lrh-1	55,60	Abcc3	Lrh-1	76408(Tax:10090)	26424(Tax:10090)	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Tumor_necrosis_factor_alpha-dependent up-regulation of Lrh-1 and Mrp3 -LRB- Abcc3 -RRB- reduces liver_injury in obstructive cholestasis .
17845218	0	Abcc6	39,44	Abcc1	21,26	Abcc6	Abcc1	27421(Tax:10090)	17250(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Targeted ablation of Abcc1 or Abcc3 in Abcc6 -LRB- - / - -RRB- mice does not modify the ectopic mineralization process .
16959944	0	Abcg2	28,33	Bcrp	22,26	Abcg2	Bcrp	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The important role of Bcrp -LRB- Abcg2 -RRB- in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen , 4-methylumbelliferone , and harmol in mice .
18356544	0	Abcg2	47,52	Hypoxia-inducible_factor-2alpha	0,31	Abcg2	Hypoxia-inducible factor-2alpha	26357(Tax:10090)	13819(Tax:10090)	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	Hypoxia-inducible_factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells .
23123212	0	Abcg2	48,53	Pregnane_X_receptor	0,19	Abcg2	Pregnane X receptor	9429	8856	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Pregnane_X_receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier .
18038765	0	Abcg4	146,151	ABCG4	89,94	Abcg4	ABCG4	192663(Tax:10090)	64137	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Development of polyclonal antibodies specific to ATP-binding cassette transporters human ABCG4 and mouse Abcg4 : site-specific expression of mouse Abcg4 in brain .
16319117	5	Abd-B	772,777	Abd-B	790,795	Abd-B	Abd-B	47763(Tax:7227)	47763(Tax:7227)	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	Although Abd-B r represses Abd-B m in the embryo , in at least part of the male A9 such regulation does not occur .
16319117	5	Abd-B	790,795	Abd-B	772,777	Abd-B	Abd-B	47763(Tax:7227)	47763(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	Although Abd-B r represses Abd-B m in the embryo , in at least part of the male A9 such regulation does not occur .
18667003	0	Abd-B	14,19	Cyclin_G	34,42	Abd-B	Cyclin G	47763(Tax:7227)	43724(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of Abd-B expression by Cyclin_G and Corto in the abdominal epithelium of Drosophila .
11741549	0	Abd-B	105,110	bithorax_complex	123,139	Abd-B	bithorax complex	47763(Tax:7227)	42034(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Replacement of Fab-7 by the gypsy or scs insulator disrupts long-distance regulatory interactions in the Abd-B gene of the bithorax_complex .
9521915	0	AbdA	38,42	Hox	43,46	AbdA	Hox	42037(Tax:7227)	42536(Tax:7227)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning .
18076572	0	Abdominal-B	77,88	DNA_supercoiling_factor	0,23	Abdominal-B	DNA supercoiling factor	47763(Tax:7227)	38145(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	DNA_supercoiling_factor positively regulates expression of the homeotic gene Abdominal-B in Drosophila_melanogaster .
16814723	0	Abdominal-B	39,50	Hox	51,54	Abdominal-B	Hox	47763(Tax:7227)	42536(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution .
12399311	0	Abdominal-B	81,92	iab-8	50,55	Abdominal-B	iab-8	47763(Tax:7227)	12798430	Gene	Gene	gene|amod|START_ENTITY domain|nmod|gene domain|amod|END_ENTITY	Genetic and molecular characterization of a novel iab-8 regulatory domain in the Abdominal-B gene of Drosophila_melanogaster .
23532844	0	Abelson-helper_integration_site_1	65,98	AHI1	100,104	Abelson-helper integration site 1	AHI1	52906(Tax:10090)	52906(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Joubert_syndrome-associated missense mutation -LRB- V443D -RRB- in the Abelson-helper_integration_site_1 -LRB- AHI1 -RRB- protein alters its localization and protein-protein interactions .
22766233	0	Abelson_interactor_protein_1	33,61	Kinesin_family_member_26B	95,120	Abelson interactor protein 1	Kinesin family member 26B	10006	55083	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The postsynaptic density protein Abelson_interactor_protein_1 interacts with the motor protein Kinesin_family_member_26B in hippocampal neurons .
17468102	0	Abeta	31,36	APP	47,50	Abeta	APP	11820(Tax:10090)	11820(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations .
17387609	0	Abeta	0,5	LGI3	39,43	Abeta	LGI3	54226(Tax:10116)	306013(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|END_ENTITY	Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes .
16849336	0	Abeta	18,23	Neuroserpin	0,11	Abeta	Neuroserpin	31002(Tax:7227)	49805(Tax:7227)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer_disease .
21179780	0	Abeta	62,67	PS-1	39,43	Abeta	PS-1	54226(Tax:10116)	29192(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of vitamin_E on expression of PS-1 and production of Abeta in the hippocampus of female senile rats -RSB- .
18405662	0	Abeta	16,21	TMP21	0,5	Abeta	TMP21	351	10972	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	TMP21 regulates Abeta production but does not affect caspase-3 , p53 , and neprilysin .
11732920	0	Abeta	95,100	apolipoprotein_E4	52,69	Abeta	apolipoprotein E4	351	348	Gene	Gene	peptide|compound|START_ENTITY END_ENTITY|nmod|peptide	Melatonin reverses the profibrillogenic activity of apolipoprotein_E4 on the Alzheimer amyloid Abeta peptide .
19158430	0	Abeta	67,72	cdk5	23,27	Abeta	cdk5	351	1020	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta -LRB- 25-35 -RRB- : involvement of lipid rafts .
16308488	0	AbetaPP	47,54	amyloid_beta_precursor_protein	15,45	AbetaPP	amyloid beta precursor protein	351	351	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of amyloid_beta_precursor_protein -LRB- AbetaPP -RRB- modulated copper_homeostasis in Alzheimer 's _ disease .
9430660	0	Abf1	41,45	Cdc6	25,29	Abf1	Cdc6	853748(Tax:4932)	853244(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Saccharomyces_cerevisiae Cdc6 stimulates Abf1 DNA binding activity .
16182283	0	Abi-1	50,55	E3B1	0,4	Abi-1	E3B1	11308(Tax:10090)	10006	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	E3B1 , a human homologue of the mouse gene product Abi-1 , sensitizes activation of Rap1 in response to epidermal growth factor .
16155590	0	Abi1	0,4	N-WASP	31,37	Abi1	N-WASP	10006	8976	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes .
19470755	0	Abl	10,13	Cdo	0,3	Abl	Cdo	25	50937	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation .
16158059	0	Abl	19,22	Crk_II	30,36	Abl	Crk II	25	1398	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Transactivation of Abl by the Crk_II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain .
23318434	0	Abl	26,29	Myc	19,22	Abl	Myc	25	4609	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dual regulation of Myc by Abl .
18809728	0	Abl	71,74	Rap1	112,116	Abl	Rap1	25	27342	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The WAVE2 complex regulates T cell receptor signaling to integrins via Abl - and CrkL-C3G-mediated activation of Rap1 .
21301049	0	Abl	14,17	Src	0,3	Abl	Src	11350(Tax:10090)	20779(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Src activates Abl to augment Robo1 expression in order to promote tumor cell migration .
8643668	0	Abl	69,72	Src	31,34	Abl	Src	25	6714	Gene	Gene	Crk|appos|START_ENTITY homology|nmod|Crk homology|nsubj|preferences preferences|nmod|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
8643668	0	Abl	69,72	Src	59,62	Abl	Src	25	6714	Gene	Gene	Crk|appos|START_ENTITY Crk|compound|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
12777393	0	Abl	32,35	c-Abl	12,17	Abl	c-Abl	25	25	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization .
12087107	0	Abl	89,92	vasodilator-stimulated_phosphoprotein	14,51	Abl	vasodilator-stimulated phosphoprotein	25	7408	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Regulation of vasodilator-stimulated_phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion .
17306257	0	Abl-SH3_binding_protein_2	0,25	CIN85	48,53	Abl-SH3 binding protein 2	CIN85	6452	30011	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Abl-SH3_binding_protein_2 , 3BP2 , interacts with CIN85 and HIP-55 .
9694699	0	Abl-interactor_1	32,48	ABI-1	0,5	Abl-interactor 1	ABI-1	11308(Tax:10090)	10006	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	ABI-1 , a human homolog to mouse Abl-interactor_1 , fuses the MLL gene in acute_myeloid_leukemia with t -LRB- 10 ; 11 -RRB- -LRB- p11 .2 ; q23 -RRB- .
1748486	0	Abp	39,42	H-2	35,38	Abp	H-2	11354(Tax:10090)	111364(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Structure function analysis of the H-2 Abp gene .
17476322	0	Abp1	47,51	Arp2/3	29,35	Abp1	Arp2/3	26	10097;10096	Gene	Gene	complex|nmod|START_ENTITY complex|amod|END_ENTITY	Regulation of N-WASP and the Arp2/3 complex by Abp1 controls neuronal morphology .
22303001	0	Abp1	42,46	DBNL	48,52	Abp1	DBNL	28988	28988	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Src-mediated phosphorylation of mammalian Abp1 -LRB- DBNL -RRB- regulates podosome rosette formation in transformed fibroblasts .
24729378	0	Absent_in_Melanoma_2	8,28	AIM2	30,34	Absent in Melanoma 2	AIM2	9447	9447	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lack of Absent_in_Melanoma_2 -LRB- AIM2 -RRB- expression in tumor cells is closely associated with poor survival in colorectal_cancer patients .
23911302	0	Acc1	41,45	StH	62,65	Acc1	StH	31	246744	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Phylogeny and molecular evolution of the Acc1 gene within the StH genome species in Triticeae -LRB- Poaceae -RRB- .
11504737	0	Ace1	72,76	Haa1	0,4	Ace1	Haa1	852710(Tax:4932)	856117(Tax:4932)	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Haa1 , a protein homologous to the copper-regulated transcription factor Ace1 , is a novel transcriptional activator .
22609398	0	Ace1p	83,88	CUP1	98,102	Ace1p	CUP1	852710(Tax:4932)	856450(Tax:4932)	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Chromatin repositioning activity and transcription machinery are both recruited by Ace1p in yeast CUP1 activation .
26975390	0	Ace2	25,29	Cts1	128,132	Ace2	Cts1	850822(Tax:4932)	850992(Tax:4932)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	The transcription factor Ace2 and its paralog Swi5 regulate ethanol production during static fermentation through their targets Cts1 and Rps4a in Saccharomyces_cerevisiae .
22985732	0	Acetoacetyl-CoA_synthetase	0,26	SREBP-2	77,84	Acetoacetyl-CoA synthetase	SREBP-2	65985	6721	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	Acetoacetyl-CoA_synthetase , a ketone body-utilizing enzyme , is controlled by SREBP-2 and affects serum cholesterol levels .
22313524	0	Acetyl-CoA_synthetase_short-chain_subfamily_member_1	8,60	Acss1	62,67	Acetyl-CoA synthetase short-chain subfamily member 1	Acss1	84532	84532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel Acetyl-CoA_synthetase_short-chain_subfamily_member_1 -LRB- Acss1 -RRB- gene indicates a dynamic history of paralogue retention and loss in vertebrates .
18371312	0	Acetyl-Coenzyme_A_acyltransferase_2	0,35	BNIP3	72,77	Acetyl-Coenzyme A acyltransferase 2	BNIP3	10449	664	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|effects effects|nmod|END_ENTITY	Acetyl-Coenzyme_A_acyltransferase_2 attenuates the apoptotic effects of BNIP3 in two human cell lines .
25383314	0	Acetylcholinesterase	0,20	AChE	22,26	Acetylcholinesterase	AChE	11423(Tax:10090)	11423(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Acetylcholinesterase -LRB- AChE -RRB- inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver .
6661467	0	Acetylcholinesterase	0,20	CSF	33,36	Acetylcholinesterase	CSF	43	1437	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Acetylcholinesterase activity in CSF in schizophrenia , depression , Alzheimer 's _ disease and normals .
20501103	0	Acetylcholinesterase	0,20	acetylcholinesterase	118,138	Acetylcholinesterase	acetylcholinesterase	100009390(Tax:9986)	100009390(Tax:9986)	Gene	Gene	START_ENTITY|dep|presence presence|nmod|END_ENTITY	Acetylcholinesterase in membrane fractions derived from sarcotubular system of skeletal muscle : presence of monomeric acetylcholinesterase in sarcoplasmic reticulum and transverse tubule membranes .
19185568	0	AchE	33,37	acetylcholinesterase	11,31	AchE	acetylcholinesterase	43	43	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Changes in acetylcholinesterase -LRB- AchE -RRB- activity in lymphocytes and whole blood in acute_lymphoblastic_leukemia patients .
24028855	0	AchE	60,64	acetylcholinesterase	38,58	AchE	acetylcholinesterase	43	43	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Effect of pharmaceuticals exposure on acetylcholinesterase -LRB- AchE -RRB- activity and on the expression of AchE gene in the monogonont rotifer , Brachionus koreanus .
26307678	0	Achaete_scute-like_2	0,20	CDX2	32,36	Achaete scute-like 2	CDX2	430	1045	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Achaete_scute-like_2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation .
19096764	0	Acheron	0,7	CASK	53,57	Acheron	CASK	67557(Tax:10090)	12361(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Acheron , an novel LA antigen family member , binds to CASK and forms a complex with Id transcription factors .
24963132	0	Aciculin	0,8	filamin_C	24,33	Aciculin	filamin C	5239	2318	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Aciculin interacts with filamin_C and Xin and is essential for myofibril assembly , remodeling and maintenance .
18579798	0	Acid-sensing_ion_channel_3	0,26	PSD-95	75,81	Acid-sensing ion channel 3	PSD-95	9311	1742	Gene	Gene	modulated|nsubjpass|START_ENTITY modulated|nmod|END_ENTITY	Acid-sensing_ion_channel_3 -LRB- ASIC3 -RRB- cell surface expression is modulated by PSD-95 within lipid rafts .
21163859	0	Acid_sphingomyelinase	0,21	AKT	84,87	Acid sphingomyelinase	AKT	20597(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	Acid_sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression .
7981153	0	Acid_sphingomyelinase	0,21	IL-1_and_tumor_necrosis_factor_receptor	47,86	Acid sphingomyelinase	IL-1 and tumor necrosis factor receptor	6609	3552	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Acid_sphingomyelinase is not essential for the IL-1_and_tumor_necrosis_factor_receptor signaling pathway leading to NFkB activation .
26918356	0	Acidic_leucine-rich_nuclear_phosphoprotein-32A	0,46	ANP32A	48,54	Acidic leucine-rich nuclear phosphoprotein-32A	ANP32A	8125	8125	Gene	Gene	association|amod|START_ENTITY association|appos|END_ENTITY	Acidic_leucine-rich_nuclear_phosphoprotein-32A -LRB- ANP32A -RRB- association with lymph_node_metastasis predicts poor survival in oral_squamous_cell_carcinoma patients .
21636789	0	Acidic_nuclear_phosphoprotein_32kDa	0,35	ANP32	37,42	Acidic nuclear phosphoprotein 32kDa	ANP32	11737(Tax:10090)	11737(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Acidic_nuclear_phosphoprotein_32kDa -LRB- ANP32 -RRB- B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development .
20432460	0	Ack1	41,45	AKT	12,15	Ack1	AKT	10188	207	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Shepherding AKT and androgen_receptor by Ack1 tyrosine kinase .
18477472	0	Ack1	39,43	Nephrocystin-1	0,14	Ack1	Nephrocystin-1	10188	4867	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct .
8088778	0	Acl	30,33	apolipoprotein_C2-linked	4,28	Acl	apolipoprotein C2-linked	11425(Tax:10090)	11425(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The apolipoprotein_C2-linked -LRB- Acl -RRB- gene : a new gene within the mouse apolipoprotein_e-c1-c2 gene cluster .
9286679	0	Acp70A	41,47	sex-peptide	28,39	Acp70A	sex-peptide	39494(Tax:7227)	39494(Tax:7227)	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Evolutionary history of the sex-peptide -LRB- Acp70A -RRB- gene region in Drosophila_melanogaster .
9573377	0	Acp70A	22,28	sex-peptide	4,15	Acp70A	sex-peptide	39494(Tax:7227)	39494(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The sex-peptide gene -LRB- Acp70A -RRB- is duplicated in Drosophila subobscura .
9718726	0	Acp70A	55,61	sex-peptide	42,53	Acp70A	sex-peptide	39494(Tax:7227)	39494(Tax:7227)	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Molecular evolution of a duplication : the sex-peptide -LRB- Acp70A -RRB- gene region of Drosophila subobscura and Drosophila madeirensis .
10853965	0	Acp_5	62,67	tartrate-resistant_acid_phosphatase	25,60	Acp 5	tartrate-resistant acid phosphatase	11433(Tax:10090)	11433(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Widespread expression of tartrate-resistant_acid_phosphatase -LRB- Acp_5 -RRB- in the mouse embryo .
22313524	0	Acss1	62,67	Acetyl-CoA_synthetase_short-chain_subfamily_member_1	8,60	Acss1	Acetyl-CoA synthetase short-chain subfamily member 1	84532	84532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel Acetyl-CoA_synthetase_short-chain_subfamily_member_1 -LRB- Acss1 -RRB- gene indicates a dynamic history of paralogue retention and loss in vertebrates .
21948371	0	Act1	12,16	IL-17	20,25	Act1	IL-17	109776(Tax:10090)	16171(Tax:10090)	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	Function of Act1 in IL-17 family signaling and autoimmunity .
23862741	0	Act1	12,16	IL-6	49,53	Act1	IL-6	10758	3569	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The role of Act1 , a NF-kB-activating protein , in IL-6 and IL-8 levels induced by IL-17 stimulation in SW982 cells .
17684298	0	Act1	43,47	cytoplasmic_adaptor	15,34	Act1	cytoplasmic adaptor	10758	353376	Gene	Gene	START_ENTITY|nsubj|role role|nmod|protein protein|compound|END_ENTITY	A role for the cytoplasmic_adaptor protein Act1 in mediating IL-17 signaling .
23202271	0	Act1	53,57	hsp90	110,115	Act1	hsp90	109776(Tax:10090)	111058(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 .
12112458	0	ActRIIB	113,120	activin_type_IIB_receptor	86,111	ActRIIB	activin type IIB receptor	11481(Tax:10090)	11481(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Gene-dosage-sensitive genetic interactions between inversus viscerum -LRB- iv -RRB- , nodal , and activin_type_IIB_receptor -LRB- ActRIIB -RRB- genes in asymmetrical patterning of the visceral organs along the left-right axis .
12953066	0	Actin	0,5	UNC-78	93,99	Actin	UNC-78	176793(Tax:6239)	180631(Tax:6239)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Actin filament disassembling activity of Caenorhabditis_elegans actin-interacting_protein_1 -LRB- UNC-78 -RRB- is dependent on filament binding by a specific ADF/cofilin isoform .
4140510	0	Actin	0,5	deoxyribonuclease_I	46,65	Actin	deoxyribonuclease I	528168(Tax:9913)	282217(Tax:9913)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Actin is the naturally occurring inhibitor of deoxyribonuclease_I .
9006895	0	Actin-binding_protein-280	0,25	SEK-1	85,90	Actin-binding protein-280	SEK-1	2318	6416	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Actin-binding_protein-280 binds the stress-activated_protein_kinase -LRB- SAPK -RRB- activator SEK-1 and is required for tumor_necrosis_factor-alpha activation of SAPK in melanoma cells .
20520827	0	Actin_88F	14,23	CF2	0,3	Actin 88F	CF2	41885(Tax:7227)	33692(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	CF2 represses Actin_88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila .
26771712	0	Activating_Transcription_Factor_4	64,97	SESN2	34,39	Activating Transcription Factor 4	SESN2	468	83667	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Mitochondrial dysfunction induces SESN2 gene expression through Activating_Transcription_Factor_4 .
12453892	0	Activating_transcription_factor-2	0,33	PEPCK	92,97	Activating transcription factor-2	PEPCK	1386	5106	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	Activating_transcription_factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic_acid .
21841196	0	Activating_transcription_factor-6	0,33	ATF6	35,39	Activating transcription factor-6	ATF6	22926	22926	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Activating_transcription_factor-6 -LRB- ATF6 -RRB- mediates apoptosis with reduction of myeloid_cell_leukemia_sequence_1 -LRB- Mcl-1 -RRB- protein via induction of WW_domain_binding_protein_1 .
20581861	0	Activating_transcription_factor_2	0,33	ATF3	74,78	Activating transcription factor 2	ATF3	1386	467	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	Activating_transcription_factor_2 -LRB- ATF2 -RRB- controls tolfenamic_acid-induced ATF3 expression via MAP kinase pathways .
19584270	0	Activating_transcription_factor_2	0,33	FoxP3	66,71	Activating transcription factor 2	FoxP3	11909(Tax:10090)	20371(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Activating_transcription_factor_2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary_tumor in the mouse .
21069729	0	Activating_transcription_factor_2	0,33	c-Fos	42,47	Activating transcription factor 2	c-Fos	11909(Tax:10090)	14281(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Activating_transcription_factor_2 targets c-Fos , but not c-Jun , in growth plate chondrocytes .
10673325	0	Activating_transcription_factor_3	0,33	ATF3	35,39	Activating transcription factor 3	ATF3	25389(Tax:10116)	25389(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Activating_transcription_factor_3 -LRB- ATF3 -RRB- induction by axotomy in sensory and motoneurons : A novel neuronal marker of nerve_injury .
20002170	0	Activating_transcription_factor_3	0,33	ATF3	35,39	Activating transcription factor 3	ATF3	467	467	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activating_transcription_factor_3 -LRB- ATF3 -RRB- expression is increased in erythema_multiforme and is regulated by IFN-gamma in human keratinocytes .
16982098	0	Activating_transcription_factor_3	0,33	CCL4	69,73	Activating transcription factor 3	CCL4	11910(Tax:10090)	20303(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Activating_transcription_factor_3 -LRB- ATF3 -RRB- represses the expression of CCL4 in murine macrophages .
25589515	0	Activating_transcription_factor_3	0,33	TGFb	54,58	Activating transcription factor 3	TGFb	11910(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Activating_transcription_factor_3 regulates canonical TGFb signalling in systemic_sclerosis .
11375399	0	Activating_transcription_factor_3	0,33	cyclin_D1	74,83	Activating transcription factor 3	cyclin D1	11910(Tax:10090)	12443(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Activating_transcription_factor_3 induces DNA synthesis and expression of cyclin_D1 in hepatocytes .
18199529	0	Activating_transcription_factor_3	0,33	nuclear_factor_erythroid-derived_2-related_factor_2	62,113	Activating transcription factor 3	nuclear factor erythroid-derived 2-related factor 2	467	4780	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Activating_transcription_factor_3 is a novel repressor of the nuclear_factor_erythroid-derived_2-related_factor_2 -LRB- Nrf2 -RRB- - regulated stress pathway .
15933712	0	Activating_transcription_factor_3	0,33	p53	62,65	Activating transcription factor 3	p53	11910(Tax:10090)	22060(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Activating_transcription_factor_3 , a stress sensor , activates p53 by blocking its ubiquitination .
20167600	0	Activating_transcription_factor_3	0,33	p53	44,47	Activating transcription factor 3	p53	467	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Activating_transcription_factor_3 activates p53 by preventing E6-associated_protein from binding to E6 .
19439225	0	Activating_transcription_factor_4	0,33	mammalian_target_of_rapamycin	98,127	Activating transcription factor 4	mammalian target of rapamycin	468	2475	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Activating_transcription_factor_4 and CCAAT/enhancer-binding _ protein-beta negatively regulate the mammalian_target_of_rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress .
21841811	0	Activating_transcription_factor_6	0,33	insulin_receptor	43,59	Activating transcription factor 6	insulin receptor	22926	3643	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Activating_transcription_factor_6 protects insulin_receptor from ER stress-stimulated desensitization via p42/44 ERK pathway .
14990977	0	Activation-induced_cytidine_deaminase	0,37	AID	93,96	Activation-induced cytidine deaminase	AID	57379	57379	Gene	Gene	expression|amod|START_ENTITY expression|dep|association association|nmod|expression expression|compound|END_ENTITY	Activation-induced_cytidine_deaminase expression in follicular_lymphoma : association between AID expression and ongoing mutation in FL .
25041363	0	Activation-induced_cytidine_deaminase	0,37	BDNF	67,71	Activation-induced cytidine deaminase	BDNF	57379	627	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Activation-induced_cytidine_deaminase regulates activity-dependent BDNF expression in post-mitotic cortical neurons .
22216188	0	Activation-induced_cytidine_deaminase	0,37	CD4	52,55	Activation-induced cytidine deaminase	CD4	57379	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Activation-induced_cytidine_deaminase expression in CD4 + T cells is associated with a unique IL-10-producing subset that increases with age .
26585164	0	Activation_Induced_Deaminase	14,42	AID	44,47	Activation Induced Deaminase	AID	57379	57379	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of Activation_Induced_Deaminase -LRB- AID -RRB- by Estrogen .
26814129	0	Activator_Protein_1	71,90	AP-1	92,96	Activator Protein 1	AP-1	3727	3727	Gene	Gene	Factor|amod|START_ENTITY Factor|appos|END_ENTITY	Megakaryocytic Maturation in Response to Shear Flow is Mediated by the Activator_Protein_1 -LRB- AP-1 -RRB- Transcription Factor via Mitogen-Activated Protein Kinase -LRB- MAPK -RRB- Mechanotransduction .
22092038	0	Activator_protein-1	0,19	AP-1	21,25	Activator protein-1	AP-1	3725	3725	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Activator_protein-1 -LRB- AP-1 -RRB- signalling in human atherosclerosis : results of a systematic evaluation and intervention study .
15718494	0	Activator_protein-1	0,19	prostaglandin_d_synthase	50,74	Activator protein-1	prostaglandin d synthase	3725	5730	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Activator_protein-1 mediates shear stress-induced prostaglandin_d_synthase gene expression in vascular endothelial cells .
10715552	0	Activator_protein-2	0,19	placental_lactogen	36,54	Activator protein-2	placental lactogen	7020	1443	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Activator_protein-2 regulates human placental_lactogen gene expression .
14565844	0	Activator_protein-2gamma	0,24	AP-2gamma	26,35	Activator protein-2gamma	AP-2gamma	7022	7022	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activator_protein-2gamma -LRB- AP-2gamma -RRB- expression is specifically induced by oestrogens through binding of the oestrogen receptor to a canonical element within the 5 ' - untranslated region .
22402664	0	Activin	110,117	Eomesodermin	0,12	Activin	Eomesodermin	83729	8320	Gene	Gene	absence|nmod|START_ENTITY induces|nmod|absence induces|nsubj|END_ENTITY	Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin .
15031321	0	Activin	0,7	Pit-1_and_menin	79,94	Activin	Pit-1 and menin	83729	5449	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Activin inhibits pituitary prolactin expression and cell growth through Smads , Pit-1_and_menin .
18166170	0	Activin	0,7	SMAD2/3	20,27	Activin	SMAD2/3	83729	4087;4088	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression .
25284780	0	Activin	29,36	Transforming_Growth_Factor_b	0,28	Activin	Transforming Growth Factor b	43826(Tax:7227)	37778(Tax:7227)	Gene	Gene	Functions|compound|START_ENTITY END_ENTITY|dep|Functions	Transforming_Growth_Factor_b / Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression .
15093610	0	Activin	0,7	p15INK4B	105,113	Activin	p15INK4B	83729	1030	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1 .
15031321	0	Activin	0,7	prolactin	27,36	Activin	prolactin	83729	5617	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Activin inhibits pituitary prolactin expression and cell growth through Smads , Pit-1_and_menin .
11070349	0	Activin-A	0,9	17beta-hydroxysteroid_dehydrogenase_type_1	38,80	Activin-A	17beta-hydroxysteroid dehydrogenase type 1	29200(Tax:10116)	25322(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Activin-A , but not inhibin , regulates 17beta-hydroxysteroid_dehydrogenase_type_1 activity and expression in cultured rat granulosa cells .
8243277	0	Activin-A	0,9	follistatin	20,31	Activin-A	follistatin	29200(Tax:10116)	24373(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells .
9518872	0	Activin-A	0,9	gonadotropin-releasing_hormone	34,64	Activin-A	gonadotropin-releasing hormone	29200(Tax:10116)	25194(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Activin-A stimulates hypothalamic gonadotropin-releasing_hormone release by the explanted male rat hypothalamus : interaction with inhibin and androgens .
2158424	0	Activin-A	0,9	growth_hormone	20,34	Activin-A	growth hormone	29200(Tax:10116)	81668(Tax:10116)	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Activin-A modulates growth_hormone secretion from cultures of rat anterior pituitary cells .
26950456	0	Activin_A	38,47	c-Jun_N-terminal_kinase	11,34	Activin A	c-Jun N-terminal kinase	29200(Tax:10116)	116554(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of c-Jun_N-terminal_kinase on Activin_A / Smads signaling in PC12 cell suffered from oxygen-glucose deprivation .
19552818	0	Activin_A	0,9	follicle_stimulating_hormone_beta	24,57	Activin A	follicle stimulating hormone beta	29200(Tax:10116)	25447(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Activin_A induces ovine follicle_stimulating_hormone_beta using -169 / -58 bp of its promoter and a simple TATA box .
23293296	0	Activin_receptor	0,16	Smad2	31,36	Activin receptor	Smad2	41772(Tax:7227)	31738(Tax:7227)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Activin_receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements .
19844808	0	Activity-dependent_neuroprotective_protein	0,42	ADNP	44,48	Activity-dependent neuroprotective protein	ADNP	11538(Tax:10090)	11538(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- expression in the amyloid precursor protein/presenilin _ 1 mouse model of Alzheimer 's _ disease .
15817463	0	Actopaxin	0,9	TESK1	25,30	Actopaxin	TESK1	55742	7016	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin .
22074949	0	Acvr2b	93,99	BMP3	0,4	Acvr2b	BMP3	11481(Tax:10090)	110075(Tax:10090)	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b .
14529612	0	Acvrinp1	39,47	Delta1	95,101	Acvrinp1	Delta1	50791(Tax:10090)	13388(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY ligand|nsubj|Interaction ligand|dobj|END_ENTITY	Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1 .
14530276	0	Acyl-CoA-binding_protein	39,63	hepatocyte_nuclear_factor-4_alpha	69,102	Acyl-CoA-binding protein	hepatocyte nuclear factor-4 alpha	25045(Tax:10116)	25735(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of Acyl-CoA-binding_protein with hepatocyte_nuclear_factor-4_alpha .
20345607	0	Acyl-CoA-binding_protein_2	0,26	lysophospholipase_2	33,52	Acyl-CoA-binding protein 2	lysophospholipase 2	828891(Tax:3702)	841709(Tax:3702)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Acyl-CoA-binding_protein_2 binds lysophospholipase_2 and lysoPC to promote tolerance to cadmium-induced oxidative stress in transgenic Arabidopsis .
22020260	0	Acyl-CoA_synthetase_1	0,21	ATP-binding_cassette_transporter_A1	109,144	Acyl-CoA synthetase 1	ATP-binding cassette transporter A1	14081(Tax:10090)	11303(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Acyl-CoA_synthetase_1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding_cassette_transporter_A1 in macrophages .
22993230	0	Acyl-CoA_thioesterase_11	65,89	thioesterase_superfamily_member_1	31,64	Acyl-CoA thioesterase 11	thioesterase superfamily member 1	329910(Tax:10090)	329910(Tax:10090)	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of thioesterase_superfamily_member_1 / Acyl-CoA_thioesterase_11 : implications for metabolic regulation .
24072708	0	Acyl-CoA_thioesterase_13	34,58	Thioesterase_superfamily_member_2	0,33	Acyl-CoA thioesterase 13	Thioesterase superfamily member 2	66834(Tax:10090)	66834(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Thioesterase_superfamily_member_2 / Acyl-CoA_thioesterase_13 -LRB- Them2/Acot13 -RRB- regulates adaptive thermogenesis in mice .
1336011	0	Ad1	45,48	CYP11B	96,102	Ad1	CYP11B	351	1584	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Cooperative transcription activation between Ad1 , a CRE-like element , and other elements in the CYP11B gene promoter .
7326748	0	Ad12	29,33	E1b	11,14	Ad12	E1b	100188830	594	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets .
8806624	0	Ad4bp	37,42	SF-1	44,48	Ad4bp	SF-1	2516	7536	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Structural characterization of human Ad4bp -LRB- SF-1 -RRB- gene .
26111641	0	Adam17	0,6	Mir-326	20,27	Adam17	Mir-326	6868	442900	Gene	Gene	START_ENTITY|appos|Target Target|nmod|END_ENTITY	Adam17 , a Target of Mir-326 , Promotes Emt-Induced Cells Invasion in Lung_Adenocarcinoma .
16231093	0	Adapt78	29,36	DSCR1	22,27	Adapt78	DSCR1	1827	1827	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Multiple roles of the DSCR1 -LRB- Adapt78 or RCAN1 -RRB- gene and its protein product calcipressin 1 -LRB- or RCAN1 -RRB- in disease .
7959767	0	Add1	87,91	Hdh	54,57	Add1	Hdh	11518(Tax:10090)	15194(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The murine homologues of the Huntington_disease gene -LRB- Hdh -RRB- and the alpha-adducin gene -LRB- Add1 -RRB- map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16 .3 .
19541651	0	Adenosine_A2A_receptor	0,22	HIF-2alpha	56,66	Adenosine A2A receptor	HIF-2alpha	135	2034	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Adenosine_A2A_receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells .
23032401	0	Adenosine_A2a_receptor	0,22	GDNF	31,35	Adenosine A2a receptor	GDNF	25369(Tax:10116)	25453(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Adenosine_A2a_receptor induces GDNF expression by the Stat3 signal in vitro .
25861440	0	Adenosine_Deaminase	26,45	ADA	47,50	Adenosine Deaminase	ADA	100	100	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	Diagnostic Value of Serum Adenosine_Deaminase -LRB- ADA -RRB- Level for Pulmonary_Tuberculosis .
871426	0	Adenosine_deaminase	0,19	ADA	21,24	Adenosine deaminase	ADA	100	100	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Adenosine_deaminase -LRB- ADA -RRB- activity in lymphocytes of normal individuals and patients with chronic_lymphatic_leukaemia .
8783262	0	Adenosine_deaminase	0,19	CD26	154,158	Adenosine deaminase	CD26	11486(Tax:10090)	13482(Tax:10090)	Gene	Gene	eminence|amod|START_ENTITY eminence|nmod|protein protein|appos|END_ENTITY	Adenosine_deaminase in rodent median eminence : detection by antibody to the mouse enzyme and co-localization with adenosine_deaminase-complexing protein -LRB- CD26 -RRB- .
9103436	0	Adenosine_deaminase	0,19	CD26	37,41	Adenosine deaminase	CD26	100	1803	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Adenosine_deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles .
14647469	0	Adenosine_deaminase	0,19	p73	70,73	Adenosine deaminase	p73	100	7161	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	Adenosine_deaminase , a key enzyme in DNA precursors control , is a new p73 target .
23123217	0	Adenylyl_cyclase_6	0,18	NKCC2	28,33	Adenylyl cyclase 6	NKCC2	11512(Tax:10090)	20495(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Adenylyl_cyclase_6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC .
23864680	0	Adf-1	36,41	FasII	92,97	Adf-1	FasII	47082(Tax:7227)	31364(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The Drosophila transcription factor Adf-1 -LRB- nalyot -RRB- regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity .
1408750	0	Adf-2	67,72	factor_2	57,65	Adf-2	factor 2	2768981(Tax:7227)	45894(Tax:7227)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization and purification of Adh distal promoter factor_2 , Adf-2 , a cell-specific and promoter-specific repressor in Drosophila .
14562961	0	Adh	70,73	alcohol_dehydrogenase	42,63	Adh	alcohol dehydrogenase	106621041	106621041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exploring the evolutionary history of the alcohol_dehydrogenase gene -LRB- Adh -RRB- duplication in species of the family tephritidae .
8973327	0	Adh-1	100,105	alcohol_dehydrogenase-1	75,98	Adh-1	alcohol dehydrogenase-1	11522(Tax:10090)	11522(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Ten kilobases of 5 ' - flanking region confers proper regulation of the mouse alcohol_dehydrogenase-1 -LRB- Adh-1 -RRB- gene in kidney and adrenal of transgenic_mice .
8018987	0	Adh-1	69,74	alcohol_dehydrogenase_1	44,67	Adh-1	alcohol dehydrogenase 1	11522(Tax:10090)	11522(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Stage and tissue-specific expression of the alcohol_dehydrogenase_1 -LRB- Adh-1 -RRB- gene during mouse development .
6328449	0	Adh1	49,53	alcohol_dehydrogenase	26,47	Adh1	alcohol dehydrogenase	542363(Tax:4577)	542363(Tax:4577)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular analysis of the alcohol_dehydrogenase -LRB- Adh1 -RRB- gene of maize .
12095699	0	Adh1	125,129	alcohol_dehydrogenase_1	100,123	Adh1	alcohol dehydrogenase 1	11522(Tax:10090)	11522(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Distal and proximal cis-linked sequences are needed for the total expression phenotype of the mouse alcohol_dehydrogenase_1 -LRB- Adh1 -RRB- gene .
2987807	0	Adh2	51,55	alcohol_dehydrogenase_2	26,49	Adh2	alcohol dehydrogenase 2	542364(Tax:4577)	542364(Tax:4577)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular analysis of the alcohol_dehydrogenase_2 -LRB- Adh2 -RRB- gene of maize .
19638541	0	Adipo-R1	40,48	adiponectin	18,29	Adipo-R1	adiponectin	51094	9370	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric_carcinoma .
17459059	0	AdipoR1	116,123	Adiponectin	0,11	AdipoR1	Adiponectin	51094	9370	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Adiponectin inhibits the growth and peritoneal metastasis of gastric_cancer through its specific membrane receptors AdipoR1 and AdipoR2 .
17911635	0	AdipoR1	73,80	Adiponectin	0,11	AdipoR1	Adiponectin	51094	9370	Gene	Gene	receptor|amod|START_ENTITY fibroblast|nmod|receptor enhances|nmod|fibroblast enhances|nsubj|END_ENTITY	Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor , AMPK , p38 , and NF-kappa_B pathway .
20444885	0	AdipoR1	58,65	Adiponectin	0,11	AdipoR1	Adiponectin	51094	9370	Gene	Gene	proliferation|nmod|START_ENTITY represses|dobj|proliferation represses|nsubj|END_ENTITY	Adiponectin represses colon_cancer cell proliferation via AdipoR1 - and - R2-mediated AMPK activation .
21321996	0	AdipoR1	69,76	Adiponectin	0,11	AdipoR1	Adiponectin	51094	9370	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathway .
23500159	0	AdipoR1	103,110	Adiponectin	0,11	AdipoR1	Adiponectin	51094	9370	Gene	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1 toxicity through AdipoR1 .
26459399	0	AdipoR1	95,102	Adiponectin	38,49	AdipoR1	Adiponectin	51094	9370	Gene	Gene	Cells|nmod|START_ENTITY Cells|nsubj|Effect Effect|nmod|END_ENTITY	in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression .
23349663	0	AdipoR1	31,38	Angiotensin_II	0,14	AdipoR1	Angiotensin II	289036(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY reduces|dobj|expression reduces|nsubj|END_ENTITY	Angiotensin_II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1 / 2/c-Myc pathway .
18842004	0	AdipoR1	26,33	ERK1/2	55,61	AdipoR1	ERK1/2	51094	5595;5594	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth .
20074551	0	AdipoR1	15,22	ERp46	0,5	AdipoR1	ERp46	51094	81567	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	ERp46 binds to AdipoR1 , but not AdipoR2 , and modulates adiponectin signalling .
18394428	0	AdipoR1	0,7	adiponectin	69,80	AdipoR1	adiponectin	51094	9370	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|actions actions|nmod|END_ENTITY	AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus .
18695895	0	AdipoR1	37,44	adiponectin	14,25	AdipoR1	adiponectin	51094	9370	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Expression of adiponectin receptors , AdipoR1 and AdipoR2 , in normal colon epithelium and colon_cancer tissue .
25582653	0	AdipoR1	14,21	adiponectin	50,61	AdipoR1	adiponectin	51094	9370	Gene	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|resistance resistance|compound|END_ENTITY	Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary_artery_disease patients ?
25892445	0	AdipoR1	120,127	adiponectin	24,35	AdipoR1	adiponectin	51094	9370	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression Differential|acl:relcl|regulated Characterisation|dep|Differential Characterisation|nmod|receptors receptors|compound|END_ENTITY	Characterisation of the adiponectin receptors : Differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks .
26251033	0	AdipoR1	76,83	adiponectin	45,56	AdipoR1	adiponectin	51094	9370	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and expression analysis of adiponectin and its receptors -LRB- AdipoR1 and AdipoR2 -RRB- in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle .
26251033	0	AdipoR1	76,83	adiponectin	45,56	AdipoR1	adiponectin	51094	9370	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and expression analysis of adiponectin and its receptors -LRB- AdipoR1 and AdipoR2 -RRB- in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle .
26453924	0	AdipoR1	91,98	adiponectin	41,52	AdipoR1	adiponectin	51094	9370	Gene	Gene	formation|compound|START_ENTITY inhibition|nmod|formation function|nmod|inhibition function|compound|END_ENTITY	High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1 / AdipoR1 signalsome formation .
22767440	0	AdipoR1	92,99	adiponectin_receptor_1	63,85	AdipoR1	adiponectin receptor 1	51094	51094	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No conclusive evidence for association of polymorphisms in the adiponectin_receptor_1 gene , AdipoR1 , with common obesity .
20423458	0	AdipoR2	0,7	ATF3	62,66	AdipoR2	ATF3	79602	467	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells .
20380822	0	AdipoR2	45,52	adiponectin_receptor_2	21,43	AdipoR2	adiponectin receptor 2	68465(Tax:10090)	68465(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A potential role for adiponectin_receptor_2 -LRB- AdipoR2 -RRB- in the regulation of alcohol intake .
17936760	0	Adiponectin	0,11	ABCA1	34,39	Adiponectin	ABCA1	9370	11303(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY suppresses|nsubj|deficiency suppresses|dobj|expression expression|compound|END_ENTITY	Adiponectin deficiency suppresses ABCA1 expression and ApoA-I synthesis in the liver .
25755733	0	Adiponectin	0,11	ABCA1	24,29	Adiponectin	ABCA1	9370	19	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Adiponectin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in RAW 264.7 macrophages .
18523726	0	Adiponectin	0,11	ADIPOQ	17,23	Adiponectin	ADIPOQ	9370	9370	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nsubj|gene	Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity .
24894086	0	Adiponectin	0,11	ADIPOQ	18,24	Adiponectin	ADIPOQ	9370	9370	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Adiponectin gene -LRB- ADIPOQ -RRB- polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type_2_diabetes .
22024046	0	Adiponectin	0,11	AMP-activated_protein_kinase	111,139	Adiponectin	AMP-activated protein kinase	9370	5563	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|amod|END_ENTITY	Adiponectin promotes hyaluronan synthesis along with increases in hyaluronan_synthase_2 transcripts through an AMP-activated_protein_kinase / peroxisome_proliferator-activated_receptor-a-dependent pathway in human dermal fibroblasts .
23535586	0	Adiponectin	0,11	AMPK	94,98	Adiponectin	AMPK	9370	5562	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|pathways pathways|compound|END_ENTITY	Adiponectin attenuates angiotensin_II-induced oxidative stress in renal tubular cells through AMPK and cAMP-Epac signal transduction pathways .
25108566	0	Adiponectin	0,11	APPL1	89,94	Adiponectin	APPL1	9370	26060	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|remodeling remodeling|nmod|END_ENTITY	Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes .
17459059	0	Adiponectin	0,11	AdipoR1	116,123	Adiponectin	AdipoR1	9370	51094	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Adiponectin inhibits the growth and peritoneal metastasis of gastric_cancer through its specific membrane receptors AdipoR1 and AdipoR2 .
17911635	0	Adiponectin	0,11	AdipoR1	73,80	Adiponectin	AdipoR1	9370	51094	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|fibroblast fibroblast|nmod|receptor receptor|amod|END_ENTITY	Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor , AMPK , p38 , and NF-kappa_B pathway .
20444885	0	Adiponectin	0,11	AdipoR1	58,65	Adiponectin	AdipoR1	9370	51094	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|proliferation proliferation|nmod|END_ENTITY	Adiponectin represses colon_cancer cell proliferation via AdipoR1 - and - R2-mediated AMPK activation .
21321996	0	Adiponectin	0,11	AdipoR1	69,76	Adiponectin	AdipoR1	9370	51094	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathway .
23500159	0	Adiponectin	0,11	AdipoR1	103,110	Adiponectin	AdipoR1	9370	51094	Gene	Gene	affects|nsubj|START_ENTITY affects|nmod|END_ENTITY	Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1 toxicity through AdipoR1 .
26459399	0	Adiponectin	38,49	AdipoR1	95,102	Adiponectin	AdipoR1	9370	51094	Gene	Gene	Effect|nmod|START_ENTITY Cells|nsubj|Effect Cells|nmod|END_ENTITY	in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression .
25475722	0	Adiponectin	0,11	Adiponectin_Receptor_1	28,50	Adiponectin	Adiponectin Receptor 1	9370	51094	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Adiponectin signals through Adiponectin_Receptor_1 to reverse imatinib resistance in K562 human chronic_myeloid_leukemia cells .
18045951	0	Adiponectin	0,11	Akt	53,56	Adiponectin	Akt	9370	207	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Adiponectin signals in prostate_cancer cells through Akt to activate the mammalian_target_of_rapamycin pathway .
21496456	0	Adiponectin	0,11	BAMBI	66,71	Adiponectin	BAMBI	9370	25805	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes .
20432444	0	Adiponectin	0,11	BMP-2	22,27	Adiponectin	BMP-2	9370	650	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Adiponectin increases BMP-2 expression in osteoblasts via AdipoR receptor signaling pathway .
24371525	0	Adiponectin	29,40	C-Reactive_Protein	56,74	Adiponectin	C-Reactive Protein	9370	1401	Gene	Gene	Level|compound|START_ENTITY Level|nmod|END_ENTITY	Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive_Protein : The INTERLIPID Study .
18451326	0	Adiponectin	0,11	C-reactive_protein	22,40	Adiponectin	C-reactive protein	9370	1401	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|synthesis synthesis|amod|END_ENTITY	Adiponectin decreases C-reactive_protein synthesis and secretion from endothelial cells : evidence for an adipose tissue-vascular loop .
20978825	0	Adiponectin	0,11	C-reactive_protein	20,38	Adiponectin	C-reactive protein	9370	1401	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Adiponectin reduces C-reactive_protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells .
18179772	0	Adiponectin	0,11	C1q	18,21	Adiponectin	C1q	9370	712	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Adiponectin binds C1q and activates the classical pathway of complement .
15356072	0	Adiponectin	0,11	CD146	26,31	Adiponectin	CD146	9370	4162	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	Adiponectin is related to CD146 , a novel marker of endothelial cell activation/injury in chronic_renal_failure and peritoneally dialyzed patients .
19490068	0	Adiponectin	0,11	CD163	26,31	Adiponectin	CD163	9370	9332	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity .
22118966	0	Adiponectin	0,11	CMKLR1	35,41	Adiponectin	CMKLR1	9370	1240	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty_liver .
19381067	0	Adiponectin	0,11	CRTC2	42,47	Adiponectin	CRTC2	9370	200186	Gene	Gene	targets|compound|START_ENTITY END_ENTITY|nsubj|targets	Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis .
23684624	0	Adiponectin	0,11	FoxO1	87,92	Adiponectin	FoxO1	9370	2308	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1 .
17911635	0	Adiponectin	0,11	IL-6	21,25	Adiponectin	IL-6	9370	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor , AMPK , p38 , and NF-kappa_B pathway .
19013427	0	Adiponectin	0,11	IL-8	23,27	Adiponectin	IL-8	9370	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts .
24065958	0	Adiponectin	28,39	Insulin	151,158	Adiponectin	Insulin	9370	101334138	Gene	Gene	Measurements|nmod|START_ENTITY Measurements|nmod|Resistance Resistance|compound|END_ENTITY	Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins -LRB- Tursiops_truncatus -RRB- with Iron Overload Reveal an Association with Insulin Resistance and Glucagon .
25793395	0	Adiponectin	49,60	Leptin	15,21	Adiponectin	Leptin	9370	3952	Gene	Gene	Ratio|compound|START_ENTITY END_ENTITY|nmod|Ratio	Elevated Serum Leptin , Adiponectin and Leptin to Adiponectin Ratio Is Associated with Chronic_Kidney_Disease in Asian Adults .
26078399	0	Adiponectin	15,26	Leptin	7,13	Adiponectin	Leptin	9370	3952	Gene	Gene	Levels|compound|START_ENTITY END_ENTITY|appos|Levels	Plasma Leptin , Adiponectin , Neuropeptide_Y Levels in Drug Naive Children With ADHD .
21321996	0	Adiponectin	0,11	MMP-3	22,27	Adiponectin	MMP-3	9370	4314	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathway .
10982546	0	Adiponectin	0,11	NF-kappaB	71,80	Adiponectin	NF-kappaB	9370	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Adiponectin , an adipocyte-derived plasma protein , inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway .
18537100	0	Adiponectin	0,11	NF-kappaB	20,29	Adiponectin	NF-kappaB	9370	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	Adiponectin	0,11	NF-kappaB	87,96	Adiponectin	NF-kappaB	9370	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|acl:relcl|leads leads|nmod|suppression suppression|nmod|activation activation|amod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
26078399	0	Adiponectin	15,26	Neuropeptide_Y	28,42	Adiponectin	Neuropeptide Y	9370	4852	Gene	Gene	Levels|compound|START_ENTITY Levels|appos|END_ENTITY	Plasma Leptin , Adiponectin , Neuropeptide_Y Levels in Drug Naive Children With ADHD .
16995820	0	Adiponectin	0,11	OPG	42,45	Adiponectin	OPG	9370	4982	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway .
26712749	0	Adiponectin	0,11	Oncostatin_M	20,32	Adiponectin	Oncostatin M	9370	5008	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Adiponectin Induces Oncostatin_M Expression in Osteoblasts through the PI3K/Akt Signaling Pathway .
20357764	0	Adiponectin	0,11	PGC-1alpha	33,43	Adiponectin	PGC-1alpha	9370	10891	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca -LRB- 2 + -RRB- and AMPK/SIRT1 .
16995820	0	Adiponectin	0,11	RANKL	23,28	Adiponectin	RANKL	9370	8600	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway .
17874043	0	Adiponectin	0,11	T-cadherin	77,87	Adiponectin	T-cadherin	9370	1012	Gene	Gene	receptors|nsubj|START_ENTITY receptors|nmod|role role|nmod|receptor receptor|appos|END_ENTITY	Adiponectin receptors , with special focus on the role of the third receptor , T-cadherin , in vascular_disease .
16115611	0	Adiponectin	0,11	TNF-alpha	20,29	Adiponectin	TNF-alpha	9370	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli .
23285079	0	Adiponectin	0,11	VCAM-1	30,36	Adiponectin	VCAM-1	9370	7412	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes .
25586350	0	Adiponectin	0,11	VEGF-A	21,27	Adiponectin	VEGF-A	9370	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Adiponectin inhibits VEGF-A in prostate_cancer cells .
18701434	0	Adiponectin	0,11	Wnt_inhibitory_factor-1	23,46	Adiponectin	Wnt inhibitory factor-1	9370	11197	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Adiponectin stimulates Wnt_inhibitory_factor-1 expression through epigenetic regulations involving the transcription factor specificity_protein_1 .
25190567	0	Adiponectin	0,11	a20	20,23	Adiponectin	a20	9370	7128	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Adiponectin induces a20 expression in adipose tissue to confer metabolic benefit .
17213280	0	Adiponectin	0,11	adiponectin	72,83	Adiponectin	adiponectin	9370	9370	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus .
18363889	0	Adiponectin	0,11	adiponectin	29,40	Adiponectin	adiponectin	9370	9370	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Adiponectin , skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone .
19914667	0	Adiponectin	0,11	apolipoprotein_B	45,61	Adiponectin	apolipoprotein B	9370	338	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Adiponectin is independently associated with apolipoprotein_B to A-1 ratio in Koreans .
17145894	0	Adiponectin	0,11	beta-catenin	57,69	Adiponectin	beta-catenin	9370	1499	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Adiponectin modulates the glycogen_synthase_kinase-3beta / beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude_mice .
16051186	0	Adiponectin	0,11	biglycan	63,71	Adiponectin	biglycan	9370	633	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Adiponectin inhibits the binding of low-density lipoprotein to biglycan , a vascular proteoglycan .
17890872	0	Adiponectin	0,11	brain_natriuretic_peptide	31,56	Adiponectin	brain natriuretic peptide	9370	4879	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Adiponectin is associated with brain_natriuretic_peptide and left_ventricular_hypertrophy in hemodialysis patients with type_2_diabetes_mellitus .
12217905	0	Adiponectin	0,11	insulin	67,74	Adiponectin	insulin	9370	3630	Gene	Gene	altered|nsubjpass|START_ENTITY altered|nmod|action action|compound|END_ENTITY	Adiponectin is not altered with exercise training despite enhanced insulin action .
14715832	0	Adiponectin	0,11	insulin	59,66	Adiponectin	insulin	9370	3630	Gene	Gene	predicts|nsubj|START_ENTITY predicts|dobj|resistance resistance|compound|END_ENTITY	Adiponectin , an adipocyte-derived protein , predicts future insulin resistance : two-year follow-up study in Japanese population .
15166309	0	Adiponectin	0,11	insulin	48,55	Adiponectin	insulin	9370	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|phenotypes phenotypes|compound|END_ENTITY	Adiponectin but not resistin is associated with insulin resistance-related phenotypes in baboons .
15599338	0	Adiponectin	1,12	insulin	77,84	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|dep|polymorphism polymorphism|nmod|development development|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Adiponectin gene polymorphism and protein dysfunction in the development of insulin resistance -RSB- .
15766512	0	Adiponectin	1,12	insulin	42,49	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|dep|link link|nmod|resistance resistance|dep|END_ENTITY	-LSB- Adiponectin : a new link between obesity , insulin resistance and cardiovascular_disease -RSB- .
15862282	0	Adiponectin	0,11	insulin	199,206	Adiponectin	insulin	9370	3630	Gene	Gene	levels|compound|START_ENTITY levels|dep|correlation correlation|nmod|independent independent|nmod|indices indices|compound|END_ENTITY	Adiponectin and resistin serum levels in women with polycystic_ovary_syndrome during oral glucose tolerance test : a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices .
15886241	0	Adiponectin	0,11	insulin	21,28	Adiponectin	insulin	9370	3630	Gene	Gene	predicts|nsubj|START_ENTITY predicts|dobj|resistance resistance|compound|END_ENTITY	Adiponectin predicts insulin resistance but not endothelial function in young , healthy adolescents .
16236252	0	Adiponectin	0,11	insulin	53,60	Adiponectin	insulin	9370	3630	Gene	Gene	represses|compound|START_ENTITY gluconeogenesis|nsubj|represses gluconeogenesis|dobj|independent independent|nmod|END_ENTITY	Adiponectin represses gluconeogenesis independent of insulin in hepatocytes .
16581078	0	Adiponectin	0,11	insulin	54,61	Adiponectin	insulin	9370	3630	Gene	Gene	variants|nsubj|START_ENTITY variants|nmod|factors factors|nmod|resistance resistance|compound|END_ENTITY	Adiponectin and its gene variants as risk factors for insulin resistance , the metabolic_syndrome and cardiovascular_disease .
16755284	0	Adiponectin	0,11	insulin	13,20	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Adiponectin , insulin resistance and clinical expression of the metabolic_syndrome in patients with Type 2 diabetes .
17071536	0	Adiponectin	0,11	insulin	45,52	Adiponectin	insulin	9370	3630	Gene	Gene	determinant|nsubj|START_ENTITY determinant|nmod|resistance resistance|compound|END_ENTITY	Adiponectin is an independent determinant of insulin resistance in women with polycystic_ovary_syndrome .
17216283	0	Adiponectin	0,11	insulin	63,70	Adiponectin	insulin	9370	3630	Gene	Gene	genes|amod|START_ENTITY genes|dep|screening screening|nmod|syndromes syndromes|nmod|resistance resistance|compound|END_ENTITY	Adiponectin receptor genes : mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations .
18535923	0	Adiponectin	0,11	insulin	44,51	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|dep|biomarker biomarker|nmod|resistance resistance|compound|END_ENTITY	Adiponectin : a biomarker of obesity-induced insulin resistance in adipose tissue and beyond .
18990088	0	Adiponectin	0,11	insulin	58,65	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|dep|soul soul|nmod|fight fight|nmod|resistance resistance|compound|END_ENTITY	Adiponectin : no longer the lone soul in the fight against insulin resistance ?
19590232	0	Adiponectin	0,11	insulin	64,71	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|resistance resistance|compound|END_ENTITY	Adiponectin in children on peritoneal_dialysis : relationship to insulin resistance and nutritional status .
19886515	0	Adiponectin	1,12	insulin	14,21	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|appos|concentrations concentrations|compound|END_ENTITY	-LSB- Adiponectin , insulin and glucose concentrations in overweight and obese subjects after a complex carbohydrates -LRB- fiber -RRB- diet -RSB- .
19906806	0	Adiponectin	0,11	insulin	15,22	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Adiponectin in insulin resistance : lessons from translational research .
20554486	0	Adiponectin	0,11	insulin	22,29	Adiponectin	insulin	9370	3630	Gene	Gene	isoforms|compound|START_ENTITY isoforms|appos|resistance resistance|compound|END_ENTITY	Adiponectin isoforms , insulin resistance and liver histology in nonalcoholic fatty liver_disease .
21198995	0	Adiponectin	0,11	insulin	27,34	Adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|nmod|relation relation|nmod|sensitivity sensitivity|compound|END_ENTITY	Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes : a prospective study in 64-year-old women .
21459325	0	Adiponectin	0,11	insulin	21,28	Adiponectin	insulin	9370	3630	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|sensitivity sensitivity|compound|END_ENTITY	Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway .
22035239	0	Adiponectin	0,11	insulin	20,27	Adiponectin	insulin	9370	3630	Gene	Gene	levels|compound|START_ENTITY levels|appos|resistance resistance|compound|END_ENTITY	Adiponectin levels , insulin resistance and their relationship with serum levels of inflammatory cytokines in patients with Beh __ et 's _ disease .
24606127	0	Adiponectin	0,11	insulin	21,28	Adiponectin	insulin	9370	3630	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|compound|END_ENTITY	Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis .
26106273	0	Adiponectin	0,11	insulin	40,47	Adiponectin	insulin	9370	3630	Gene	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|resistance resistance|compound|END_ENTITY	Adiponectin serum levels correlate with insulin resistance in type 2 diabetic patients .
24667577	0	Adiponectin	0,11	intercellular_adhesion_molecule-1	21,54	Adiponectin	intercellular adhesion molecule-1	9370	3383	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Adiponectin enhances intercellular_adhesion_molecule-1 expression and promotes monocyte adhesion in human synovial fibroblasts .
18795895	0	Adiponectin	0,11	interleukin-6	20,33	Adiponectin	interleukin-6	11450(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Adiponectin induces interleukin-6 production and activates STAT3 in adult mouse cardiac fibroblasts .
23210469	0	Adiponectin	0,11	interleukin-6	13,26	Adiponectin	interleukin-6	9370	3569	Gene	Gene	factors|compound|START_ENTITY factors|amod|END_ENTITY	Adiponectin , interleukin-6 , and cardiovascular_disease risk factors are modified by a short-term yoga-based lifestyle intervention in overweight and obese men .
16269654	0	Adiponectin	0,11	interleukin-8	46,59	Adiponectin	interleukin-8	9370	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|END_ENTITY	Adiponectin inhibits endothelial synthesis of interleukin-8 .
22592205	0	Adiponectin	0,11	leptin	15,21	Adiponectin	leptin	9370	3952	Gene	Gene	START_ENTITY|nmod|index index|compound|END_ENTITY	Adiponectin to leptin index as a marker of endometrial_cancer in postmenopausal women with abnormal vaginal_bleeding : an observational study .
23115066	0	Adiponectin	0,11	leptin	13,19	Adiponectin	leptin	9370	3952	Gene	Gene	START_ENTITY|appos|concentrations concentrations|compound|END_ENTITY	Adiponectin , leptin , resistin and insulin blood concentrations in patients with ischaemic_cerebral_stroke .
18956641	0	Adiponectin	1,12	osteoprotegerin	41,56	Adiponectin	osteoprotegerin	9370	4982	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Adiponectin regulates the expression of osteoprotegerin and receptor_activator_of_nuclear_factor-kappaB_ligand in human osteoblast -RSB- .
22039048	0	Adiponectin	0,11	p38MAPK	147,154	Adiponectin	p38MAPK	9370	1432	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38_mitogen-activated_protein_kinase -LRB- p38MAPK -RRB- / glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- / b-catenin signaling cascade .
15116265	0	Adiponectin	0,11	plasminogen_activator_inhibitor_type_1	36,74	Adiponectin	plasminogen activator inhibitor type 1	9370	5054	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	Adiponectin is inversely related to plasminogen_activator_inhibitor_type_1 in patients with stable exertional angina .
17940218	0	Adiponectin	0,11	tumor_necrosis_factor-alpha	60,87	Adiponectin	tumor necrosis factor-alpha	9370	7124	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|acl|induced induced|nmod|END_ENTITY	Adiponectin suppresses IkappaB kinase activation induced by tumor_necrosis_factor-alpha or high glucose in endothelial cells : role of cAMP and AMP kinase signaling .
18174285	0	Adiponectin	0,11	tumor_necrosis_factor-alpha	46,73	Adiponectin	tumor necrosis factor-alpha	9370	7124	Gene	Gene	antagonizes|compound|START_ENTITY effect|dep|antagonizes effect|nmod|END_ENTITY	Adiponectin antagonizes stimulatory effect of tumor_necrosis_factor-alpha on vascular smooth muscle cell calcification : regulation of growth_arrest-specific_gene_6-mediated survival pathway by adenosine_5 ' - monophosphate-activated protein kinase .
19883500	0	Adiponectin	0,11	vascular_endothelial_growth_factor	101,135	Adiponectin	vascular endothelial growth factor	9370	7422	Gene	Gene	contribute|nsubj|START_ENTITY contribute|advcl|stimulating stimulating|xcomp|END_ENTITY	Adiponectin may contribute to synovitis and joint destruction in rheumatoid_arthritis by stimulating vascular_endothelial_growth_factor , matrix metalloproteinase-1 , and matrix_metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators .
25475722	0	Adiponectin_Receptor_1	28,50	Adiponectin	0,11	Adiponectin Receptor 1	Adiponectin	51094	9370	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Adiponectin signals through Adiponectin_Receptor_1 to reverse imatinib resistance in K562 human chronic_myeloid_leukemia cells .
15277397	0	Adiponectin_receptor_1	0,22	ADIPOR1	29,36	Adiponectin receptor 1	ADIPOR1	51094	51094	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Adiponectin_receptor_1 gene -LRB- ADIPOR1 -RRB- as a candidate for type 2 diabetes and insulin resistance .
22387454	0	Adiponectin_receptor_1	0,22	ADIPOR1	29,36	Adiponectin receptor 1	ADIPOR1	51094	51094	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Adiponectin_receptor_1 gene -LRB- ADIPOR1 -RRB- variant is associated with advanced age-related_macular_degeneration in Finnish population .
22340319	0	Adiponectin_receptor_1	0,22	adiponectin	50,61	Adiponectin receptor 1	adiponectin	51094	9370	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|difference difference|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Adiponectin_receptor_1 mediates the difference in adiponectin - induced prostaglandin_E2 production in rheumatoid_arthritis and osteoarthritis synovial fibroblasts .
23512946	0	Adipose	0,7	adipose	29,36	Adipose	adipose	230796(Tax:10090)	230796(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	Adipose tissue expression of adipose -LRB- WDTC1 -RRB- gene is associated with lower fat mass and enhanced insulin sensitivity in humans .
18073138	0	Adipose	0,7	catalase	22,30	Adipose	catalase	230796(Tax:10090)	12359(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Adipose expression of catalase is regulated via a novel remote PPARgamma-responsive region .
26731658	0	Adipose_Differentiation-Related_Protein	72,111	Occludin	28,36	Adipose Differentiation-Related Protein	Occludin	123	100506658	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Hepatitis_C_Virus Increases Occludin Expression via the Upregulation of Adipose_Differentiation-Related_Protein .
18224330	0	Adipose_triglyceride_lipase	0,27	ATGL	29,33	Adipose triglyceride lipase	ATGL	57104	57104	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Adipose_triglyceride_lipase -LRB- ATGL -RRB- expression in human skeletal muscle is type I -LRB- oxidative -RRB- fiber specific .
22836232	0	Adipose_triglyceride_lipase	0,27	ATGL	29,33	Adipose triglyceride lipase	ATGL	104928846	104928846	Gene	Gene	clone|compound|START_ENTITY clone|compound|END_ENTITY	Adipose_triglyceride_lipase -LRB- ATGL -RRB- clone , expression pattern , and regulation by different lipid sources and lipid levels in large_yellow_croaker -LRB- Pseudosciaena_crocea R. -RRB- .
11495982	0	Adr1	0,4	ADH2	88,92	Adr1	ADH2	851802(Tax:4932)	855349(Tax:4932)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Adr1 and Cat8 synergistically activate the glucose-regulated alcohol dehydrogenase gene ADH2 of the yeast Saccharomyces_cerevisiae .
12748191	0	Adr1p	106,111	PIP2	25,29	Adr1p	PIP2	851802(Tax:4932)	854545(Tax:4932)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Saccharomyces_cerevisiae PIP2 mediating oleic_acid induction and peroxisome proliferation is regulated by Adr1p and Pip2p-Oaf1p .
8988798	0	Adrenocorticotropic_hormone	0,27	corticotropin-releasing_hormone	54,85	Adrenocorticotropic hormone	corticotropin-releasing hormone	5443	1392	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Adrenocorticotropic_hormone and cortisol responses to corticotropin-releasing_hormone : changes in panic_disorder and effects of alprazolam treatment .
1649836	0	Adrenocorticotropin	0,19	vasopressin	46,57	Adrenocorticotropin	vasopressin	5443	551	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|nsubj|responses	Adrenocorticotropin and cortisol responses to vasopressin during pregnancy .
14733413	0	Adrenomedullin	0,14	MCP-1	51,56	Adrenomedullin	MCP-1	25026(Tax:10116)	24770(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Adrenomedullin inhibits pressure-induced mesangial MCP-1 expression through activation of protein_kinase_A .
15527794	0	Adrenomedullin	0,14	NF-kappaB	31,40	Adrenomedullin	NF-kappaB	133	4790	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Adrenomedullin signals through NF-kappaB in epithelial cells .
22178239	0	Adrenomedullin	0,14	VEGF	30,34	Adrenomedullin	VEGF	133	7422	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Adrenomedullin interacts with VEGF in endometrial_cancer and has varied modulation in tumours of different grades .
10409481	0	Adrenomedullin	0,14	adrenomedullin	88,102	Adrenomedullin	adrenomedullin	133	133	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Adrenomedullin in monocytes and macrophages : possible involvement of macrophage-derived adrenomedullin in atherogenesis .
14751847	0	Adrenomedullin	0,14	angiotensin_II	60,74	Adrenomedullin	angiotensin II	25026(Tax:10116)	24179(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Adrenomedullin modulates hemodynamic and cardiac effects of angiotensin_II in conscious rats .
9749824	0	Adrenomedullin	0,14	atrial_natriuretic_factor	26,51	Adrenomedullin	atrial natriuretic factor	25026(Tax:10116)	24602(Tax:10116)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Adrenomedullin suppresses atrial_natriuretic_factor -LRB- ANF -RRB- secretion from isolated atrium .
8526913	0	Adrenomedullin	0,14	c-fos	37,42	Adrenomedullin	c-fos	25026(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Adrenomedullin induces expression of c-fos and AP-1 activity in rat vascular smooth muscle cells and cardiomyocytes .
11159365	0	Adrenomedullin	0,14	endothelin-1	102,114	Adrenomedullin	endothelin-1	25026(Tax:10116)	24323(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|contraction contraction|nmod|cells cells|acl|induced induced|advcl|END_ENTITY	Adrenomedullin inhibits the contraction of cultured rat testicular peritubular myoid cells induced by endothelin-1 .
21824440	0	Adrenomedullin	0,14	endothelin-1	94,106	Adrenomedullin	endothelin-1	25026(Tax:10116)	24323(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Adrenomedullin in rat follicles and corpora lutea : expression , functions and interaction with endothelin-1 .
9514921	0	Adrenomedullin	0,14	interleukin-6	26,39	Adrenomedullin	interleukin-6	11535(Tax:10090)	16193(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Adrenomedullin stimulates interleukin-6 production in Swiss_3T3 cells .
26002630	0	Adrenomedullin	0,14	myelin-basic-protein	80,100	Adrenomedullin	myelin-basic-protein	25026(Tax:10116)	24547(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro .
26002630	0	Adrenomedullin	0,14	myelin-basic-protein	80,100	Adrenomedullin	myelin-basic-protein	25026(Tax:10116)	24547(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro .
18418734	0	Adrenomedullin-2	0,16	intermedin	17,27	Adrenomedullin-2	intermedin	399475(Tax:10116)	399475(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Adrenomedullin-2 / intermedin induces cAMP accumulation in dissociated rat spinal cord cells : evidence for the existence of a distinct class of sites of action .
20596793	0	Adrenomedullin_2	0,16	intermedin	17,27	Adrenomedullin 2	intermedin	79924	79924	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Adrenomedullin_2 / intermedin in the hypothalamo-pituitary-adrenal axis .
21816853	0	Adrenomedullin_2	0,16	intermedin	17,27	Adrenomedullin 2	intermedin	79924	79924	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Adrenomedullin_2 / intermedin regulates HLA-G in human trophoblasts .
18325335	0	Affixin	0,7	Rac1	18,22	Affixin	Rac1	170736(Tax:10090)	19353(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Affixin activates Rac1 via betaPIX in C2C12 myoblast .
20348100	0	Afp	87,90	Foxa1	0,5	Afp	Foxa1	174	3169	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells .
1979024	0	Afp	79,82	Mgsa	65,69	Afp	Mgsa	11576(Tax:10090)	14825(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Localization of mouse melanoma growth stimulatory activity gene -LRB- Mgsa -RRB- between Afp and Gus on chromosome 5 using interspecific backcross mice .
22157760	0	Aft1	37,41	Iml3	77,81	Aft1	Iml3	852809(Tax:4932)	852404(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Iron-responsive transcription factor Aft1 interacts with kinetochore protein Iml3 and promotes pericentromeric cohesin .
25300486	0	Aft1	20,24	Rad9	0,4	Aft1	Rad9	852809(Tax:4932)	851803(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. _ cerevisiae .
11777338	0	Ag-9C5	53,59	FIP2	37,41	Ag-9C5	FIP2	374079(Tax:9031)	374079(Tax:9031)	Gene	Gene	localization|amod|START_ENTITY localization|nmod|END_ENTITY	Differential localization of chicken FIP2 homologue , Ag-9C5 , in secretory epithelial cells .
19059445	0	AgRP	95,99	Agouti-related_protein	71,93	AgRP	Agouti-related protein	25582(Tax:10116)	25582(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Enterostatin affects cyclic_AMP and ERK signaling pathways to regulate Agouti-related_protein -LRB- AgRP -RRB- expression .
26500840	0	AgRP	56,60	GluN2B	23,29	AgRP	GluN2B	11604(Tax:10090)	14812(Tax:10090)	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis .
19817504	0	AgRP	32,36	IL-6	48,52	AgRP	IL-6	25582(Tax:10116)	24498(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
19817504	0	AgRP	32,36	NPY	27,30	AgRP	NPY	25582(Tax:10116)	24604(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
15597192	0	AgRP	38,42	agouti-related_protein	14,36	AgRP	agouti-related protein	101804660	101804660	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of agouti-related_protein -LRB- AgRP -RRB- in the hypothalamus and adrenal gland of the duck -LRB- Anas_platyrhynchos -RRB- .
20102560	0	AgRP	52,56	agouti-related_protein	28,50	AgRP	agouti-related protein	11604(Tax:10090)	11604(Tax:10090)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Ethanol-induced increase of agouti-related_protein -LRB- AgRP -RRB- immunoreactivity in the arcuate nucleus of the hypothalamus of C57BL/6J , but not 129/SvJ , inbred mice .
23774689	0	AgRP	80,84	agouti-related_protein	56,78	AgRP	agouti-related protein	181	181	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Characterization , tissue distribution and regulation of agouti-related_protein -LRB- AgRP -RRB- in a cyprinid fish -LRB- Schizothorax prenanti -RRB- .
23936608	0	Age-related_hearing_loss	0,24	Mn-SOD	28,34	Age-related hearing loss	Mn-SOD	22295(Tax:10090)	20656(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Age-related_hearing_loss in Mn-SOD heterozygous_knockout mice .
21135091	0	Age1	40,44	phospholipase_D	61,76	Age1	phospholipase D	852136(Tax:4932)	853902(Tax:4932)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase_D for post-Golgi vesicular transport .
17470431	0	Aggrecanase-1	31,44	ADAMTS-4	21,29	Aggrecanase-1	ADAMTS-4	9507	9507	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	TIMP-3 inhibition of ADAMTS-4 -LRB- Aggrecanase-1 -RRB- is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4 .
19767207	0	Aggrecanase-2	84,97	ADAMTS-5	74,82	Aggrecanase-2	ADAMTS-5	11096	11096	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and SAR_of_2-phenyl-1-sulfonylaminocyclopropane_carboxylates as ADAMTS-5 -LRB- Aggrecanase-2 -RRB- inhibitors .
25709087	0	Aggrecanase_1	87,100	ADAMTS-4	77,85	Aggrecanase 1	ADAMTS-4	9507	9507	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	CCN1 -LRB- Cyr61 -RRB- Is Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 -LRB- Aggrecanase_1 -RRB- Activity .
25898270	0	Agouti-Related_Protein	86,108	Melanocortin-4_Receptor	154,177	Agouti-Related Protein	Melanocortin-4 Receptor	11604(Tax:10090)	17202(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY Mimetic|nmod|-LSB- Discovery|nmod|Mimetic AGRP|nsubj|Discovery AGRP|nmod|END_ENTITY	Discovery of a b-Hairpin Octapeptide , c -LSB- Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro -RSB- , Mimetic of Agouti-Related_Protein -LRB- 87-132 -RRB- -LSB- AGRP -LRB- 87-132 -RRB- -RSB- with Equipotent Mouse Melanocortin-4_Receptor -LRB- mMC4R -RRB- Antagonist Pharmacology .
19059445	0	Agouti-related_protein	71,93	AgRP	95,99	Agouti-related protein	AgRP	25582(Tax:10116)	25582(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Enterostatin affects cyclic_AMP and ERK signaling pathways to regulate Agouti-related_protein -LRB- AgRP -RRB- expression .
11257308	0	Agouti-related_protein	0,22	melanocortin-4_receptor	88,111	Agouti-related protein	melanocortin-4 receptor	11604(Tax:10090)	17202(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Agouti-related_protein functions as an inverse agonist at a constitutively active brain melanocortin-4_receptor .
14709157	0	Agouti-related_protein	0,22	melanocortin-4_receptor	73,96	Agouti-related protein	melanocortin-4 receptor	181	4160	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Agouti-related_protein -LRB- 83-132 -RRB- is a competitive antagonist at the human melanocortin-4_receptor : no evidence for differential interactions with pro-opiomelanocortin-derived ligands .
15996791	0	Agouti-related_protein	0,22	melanocortin-4_receptor	36,59	Agouti-related protein	melanocortin-4 receptor	11604(Tax:10090)	17202(Tax:10090)	Gene	Gene	START_ENTITY|dep|antagonist antagonist|amod|END_ENTITY	Agouti-related_protein : more than a melanocortin-4_receptor antagonist ?
23209296	0	Agr2	29,33	anterior_gradient_2	8,27	Agr2	anterior gradient 2	23795(Tax:10090)	23795(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of anterior_gradient_2 -LRB- Agr2 -RRB- expression results in hyperplasia and defective lineage maturation in the murine stomach .
20505824	0	Agrin	0,5	BMP2	12,16	Agrin	BMP2	25592(Tax:10116)	29373(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Agrin binds BMP2 , BMP4 and TGFbeta1 .
18848351	0	Agrin	23,28	Lrp4	0,4	Agrin	Lrp4	375790	4038	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Lrp4 is a receptor for Agrin and forms a complex with MuSK .
21969364	0	Agrin	0,5	Lrp4	40,44	Agrin	Lrp4	375790	4038	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|region region|nmod|protein protein|amod|END_ENTITY	Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific_kinase -LRB- MuSK -RRB- .
21969364	0	Agrin	0,5	Lrp4	88,92	Agrin	Lrp4	375790	4038	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|region region|nmod|protein protein|nmod|END_ENTITY	Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific_kinase -LRB- MuSK -RRB- .
1655973	0	Agrin	0,5	alpha-actinin	14,27	Agrin	alpha-actinin	396538(Tax:9031)	396024(Tax:9031)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Agrin induces alpha-actinin , filamin , and vinculin to co-localize with AChR clusters on cultured chick myotubes .
19325217	0	Agrin	0,5	leukemia_inhibitory_factor	31,57	Agrin	leukemia inhibitory factor	11603(Tax:10090)	16878(Tax:10090)	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	Agrin pathway is controlled by leukemia_inhibitory_factor -LRB- LIF -RRB- in murine implantation .
15345681	0	Agrp	54,58	agouti-related_protein	30,52	Agrp	agouti-related protein	11604(Tax:10090)	11604(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of agouti-related_protein -LRB- Agrp -RRB- in transgenic_mice .
11179451	0	AhR	27,30	ARNT	58,62	AhR	ARNT	196	405	Gene	Gene	receptor|appos|START_ENTITY Aryl_hydrocarbon|dep|receptor Aryl_hydrocarbon|parataxis|unaltered unaltered|nsubj|activity activity|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- / AhR nuclear translocator -LRB- ARNT -RRB- activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded -LRB- PAS -RRB- - region serine residue .
11179451	0	AhR	32,35	ARNT	58,62	AhR	ARNT	196	405	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Aryl_hydrocarbon receptor -LRB- AhR -RRB- / AhR nuclear translocator -LRB- ARNT -RRB- activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded -LRB- PAS -RRB- - region serine residue .
22981438	0	AhR	31,34	ARNT	20,24	AhR	ARNT	196	405	Gene	Gene	manner|compound|START_ENTITY END_ENTITY|nmod|manner	SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4 + CD8 + DPK thymocytes differentiation .
9759704	0	AhR	45,48	ARNT	106,110	AhR	ARNT	196	405	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- and the aryl_hydrocarbon_receptor nuclear translocator -LRB- ARNT -RRB- in fetal , benign hyperplastic , and malignant prostate .
14678789	0	AhR	98,101	Ah_receptor	85,96	AhR	Ah receptor	196	196	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphism analysis and functional characterization of the human Ah_receptor -LRB- AhR -RRB- gene promoter .
12520072	0	AhR	66,69	Arnt	115,119	AhR	Arnt	196	405	Gene	Gene	Correlation|appos|START_ENTITY Correlation|appos|receptor receptor|dep|translocator translocator|appos|END_ENTITY	Correlation between gene expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- , hydrocarbon receptor nuclear translocator -LRB- Arnt -RRB- , cytochromes P4501A1 -LRB- CYP1A1 -RRB- and 1B1 -LRB- CYP1B1 -RRB- , and inducibility of CYP1A1 and CYP1B1 in human lymphocytes .
9022676	0	AhR	41,44	Arnt	98,102	AhR	Arnt	100008995(Tax:9986)	100008996(Tax:9986)	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- Arnt -RRB- in adult rabbits known to be non-responsive to cytochrome_P-450_1A1 -LRB- CYP1A1 -RRB- inducers .
26860885	0	AhR	47,50	Aryl_Hydrocarbon_Receptor	20,45	AhR	Aryl Hydrocarbon Receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Crucial Role of the Aryl_Hydrocarbon_Receptor -LRB- AhR -RRB- in Indoxyl_Sulfate-Induced Vascular_Inflammation .
22500183	0	AhR	38,41	Arylhydrocarbon_Receptor	12,36	AhR	Arylhydrocarbon Receptor	196	196	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the Arylhydrocarbon_Receptor -LRB- AhR -RRB- in the Pathology of Asthma and COPD .
12490139	0	AhR	123,126	CD4	146,149	AhR	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12490139	0	AhR	53,56	CD4	146,149	AhR	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|dep|expression expression|nmod|+ +|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
21525997	0	AhR	103,106	CD4	57,60	AhR	CD4	196	920	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY cells|nmod|aryl_hydrocarbon_receptor favors|nsubj|cells favors|nmod|T T|compound|END_ENTITY	In vivo dioxin favors interleukin-22 production by human CD4 + T cells in an aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent manner .
22609446	0	AhR	31,34	CD4	91,94	AhR	CD4	196	920	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY ligand|nsubj|aryl_hydrocarbon_receptor ligand|ccomp|acts acts|nmod|monocytes monocytes|acl|ve ve|dobj|cells cells|amod|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AhR -RRB- ligand VAF347 selectively acts on monocytes and na ve CD4 -LRB- + -RRB- Th cells to promote the development of IL-22-secreting Th cells .
10631103	0	AhR	44,47	CYP1A1	13,19	AhR	CYP1A1	196	1543	Gene	Gene	pathway|compound|START_ENTITY Induction|nmod|pathway Induction|nmod|END_ENTITY	Induction of CYP1A1 by serum independent of AhR pathway .
11324719	0	AhR	88,91	CYP1A1	46,52	AhR	CYP1A1	196	1543	Gene	Gene	pathway|compound|START_ENTITY HepG2|nmod|pathway gene|nmod|HepG2 gene|nummod|END_ENTITY	Serum induces a transcriptional activation of CYP1A1 gene in HepG2 independently of the AhR pathway .
11698344	0	AhR	50,53	CYP1A1	102,108	AhR	CYP1A1	196	1543	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY gene|compound|aryl_hydrocarbon_receptor Polymorphisms|nmod|gene Polymorphisms|dep|relationship relationship|nmod|inducibility inducibility|compound|END_ENTITY	Polymorphisms of human aryl_hydrocarbon_receptor -LRB- AhR -RRB- gene in a French population : relationship with CYP1A1 inducibility and lung_cancer .
15667830	0	AhR	183,186	CYP1A1	13,19	AhR	CYP1A1	11622(Tax:10090)	13076(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of CYP1A1 and CYP1B1 in liver and lung by benzo -LRB- a -RRB- pyrene and 7,12-d _ imethylbenz -LRB- a -RRB- anthracene do not affect distribution of polycyclic_hydrocarbons to target tissue : role of AhR and CYP1B1 in bone marrow_cytotoxicity .
16985033	0	AhR	32,35	CYP1A1	37,43	AhR	CYP1A1	196	1543	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association of polymorphisms in AhR , CYP1A1 , GSTM1 , and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers .
19022236	0	AhR	50,53	CYP1A1	64,70	AhR	CYP1A1	196	1543	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|dep|END_ENTITY	Dexamethasone controls aryl_hydrocarbon_receptor -LRB- AhR -RRB- - mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes .
20187624	0	AhR	68,71	CYP1A1	39,45	AhR	CYP1A1	196	1543	Gene	Gene	induce|nmod|START_ENTITY induce|dobj|END_ENTITY	3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms , respectively .
21342125	0	AhR	83,86	CYP1A1	44,50	AhR	CYP1A1	196	1543	Gene	Gene	enzyme|appos|START_ENTITY enzyme|appos|END_ENTITY	The function of cytochrome_P450_1A1 enzyme -LRB- CYP1A1 -RRB- and aryl_hydrocarbon_receptor -LRB- AhR -RRB- in the placenta .
21963808	0	AhR	10,13	CYP1A1	100,106	AhR	CYP1A1	11622(Tax:10090)	13076(Tax:10090)	Gene	Gene	sites|amod|START_ENTITY caused|nsubj|sites caused|dobj|induction induction|compound|END_ENTITY	Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes .
24120730	0	AhR	40,43	CYP1A1	62,68	AhR	CYP1A1	196	1543	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Effects of artificial sweeteners on the AhR - and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells .
9022676	0	AhR	41,44	CYP1A1	173,179	AhR	CYP1A1	100008995(Tax:9986)	100328613(Tax:9986)	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY Expression|nmod|aryl_hydrocarbon_receptor Expression|acl|known known|xcomp|non-responsive non-responsive|nmod|inducers inducers|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- Arnt -RRB- in adult rabbits known to be non-responsive to cytochrome_P-450_1A1 -LRB- CYP1A1 -RRB- inducers .
16820944	0	AhR	65,68	CYP1A2	26,32	AhR	CYP1A2	25690(Tax:10116)	24297(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway expression|nmod|cells expression|compound|END_ENTITY	Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway : the central role of proinflammatory cytokines .
19854261	0	AhR	84,87	CYP1A2	137,143	AhR	CYP1A2	196	1544	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Effects of dinuclear_copper -LRB- II -RRB- complexes with 6 - -LRB- benzylamino -RRB- purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes .
18059014	0	AhR	68,71	CYP1B1	27,33	AhR	CYP1B1	196	1545	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Constitutive regulation of CYP1B1 by the aryl_hydrocarbon_receptor -LRB- AhR -RRB- in pre-malignant and malignant mammary tissue .
25349783	0	AhR	59,62	HSP90	87,92	AhR	HSP90	196	3320	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	The activation mechanism of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- by molecular chaperone HSP90 .
27000947	0	AhR	0,3	IL-22	18,23	AhR	IL-22	11622(Tax:10090)	50929(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	AhR modulates the IL-22 producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model .
15585952	0	AhR	49,52	PPARalpha	27,36	AhR	PPARalpha	25690(Tax:10116)	25747(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY ligand|nsubj|function ligand|nmod|regulation regulation|nmod|END_ENTITY	Down regulation of hepatic PPARalpha function by AhR ligand .
17963696	0	AhR	36,39	PPARalpha	0,9	AhR	PPARalpha	196	5465	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	PPARalpha transcriptionally induces AhR expression in Caco-2 , but represses AhR pro-inflammatory effects .
10722677	0	AhR	86,89	aryl_hydrocarbon_receptor	59,84	AhR	aryl hydrocarbon receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- by the ubiquitin-proteasome pathway .
10961990	0	AhR	38,41	aryl_hydrocarbon_receptor	11,36	AhR	aryl hydrocarbon receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of aryl_hydrocarbon_receptor -LRB- AhR -RRB- to AhR-interacting_protein .
12490139	0	AhR	123,126	aryl_hydrocarbon_receptor	26,51	AhR	aryl hydrocarbon receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12520072	0	AhR	66,69	aryl_hydrocarbon_receptor	39,64	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation between gene expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- , hydrocarbon receptor nuclear translocator -LRB- Arnt -RRB- , cytochromes P4501A1 -LRB- CYP1A1 -RRB- and 1B1 -LRB- CYP1B1 -RRB- , and inducibility of CYP1A1 and CYP1B1 in human lymphocytes .
18378297	0	AhR	60,63	aryl_hydrocarbon_receptor	33,58	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Estrogenic effect of dioxin-like aryl_hydrocarbon_receptor -LRB- AhR -RRB- agonist -LRB- PCB congener 126 -RRB- in salmon hepatocytes .
21627536	0	AhR	37,40	aryl_hydrocarbon_receptor	10,35	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of aryl_hydrocarbon_receptor -LRB- AhR -RRB- knockdown on cell cycle progression in human HaCaT keratinocytes .
21858153	0	AhR	41,44	aryl_hydrocarbon_receptor	14,39	AhR	aryl hydrocarbon receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis .
23963493	0	AhR	39,42	aryl_hydrocarbon_receptor	12,37	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- in lung_inflammation .
24565903	0	AhR	56,59	aryl_hydrocarbon_receptor	29,54	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	IL-1 and TNF-a regulation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in HSY human salivary cells .
25316167	0	AhR	64,67	aryl_hydrocarbon_receptor	37,62	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	DDE and PCB_153 independently induce aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in peripheral blood mononuclear cells .
25349783	0	AhR	59,62	aryl_hydrocarbon_receptor	32,57	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	The activation mechanism of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- by molecular chaperone HSP90 .
25797602	0	AhR	75,78	aryl_hydrocarbon_receptor	48,73	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	pathway|appos|START_ENTITY pathway|compound|END_ENTITY	TCDD and omeprazole prime platelets through the aryl_hydrocarbon_receptor -LRB- AhR -RRB- non-genomic pathway .
26219504	0	AhR	88,91	aryl_hydrocarbon_receptor	50,75	AhR	aryl hydrocarbon receptor	25690(Tax:10116)	25690(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Hexachlorobenzene induces cell proliferation , and aryl_hydrocarbon_receptor expression -LRB- AhR -RRB- in rat liver preneoplastic foci , and in the human hepatoma cell line HepG2 .
26219504	0	AhR	88,91	aryl_hydrocarbon_receptor	50,75	AhR	aryl hydrocarbon receptor	25690(Tax:10116)	25690(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Hexachlorobenzene induces cell proliferation , and aryl_hydrocarbon_receptor expression -LRB- AhR -RRB- in rat liver preneoplastic foci , and in the human hepatoma cell line HepG2 .
26513682	0	AhR	39,42	aryl_hydrocarbon_receptor	12,37	AhR	aryl hydrocarbon receptor	196	196	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of aryl_hydrocarbon_receptor -LRB- AhR -RRB- in the pathology of pleomorphic_adenoma in parotid gland .
11681798	0	AhR	46,49	arylhydrocarbon_receptor	20,44	AhR	arylhydrocarbon receptor	100008995(Tax:9986)	100008995(Tax:9986)	Gene	Gene	control|appos|START_ENTITY control|nmod|END_ENTITY	Hormonal control of arylhydrocarbon_receptor -LRB- AhR -RRB- expression in the preimplantation rabbit uterus .
12738279	0	AhR	51,54	arylhydrocarbon_receptor	25,49	AhR	arylhydrocarbon receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Functional activation of arylhydrocarbon_receptor -LRB- AhR -RRB- in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
9733792	0	AhR	38,41	mArnt	64,69	AhR	mArnt	11622(Tax:10090)	11863(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and expression of the mouse AhR nuclear translocator -LRB- mArnt -RRB- gene .
11096091	1	AhR	36,39	mdr1	124,128	AhR	mdr1	11622(Tax:10090)	110357(Tax:10090)	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	AhR nuclear translocator - and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo -LRB- a -RRB- pyrene in hepatoma cells .
16755028	0	AhRR	62,66	aryl_hydrocarbon_receptor_repressor	25,60	AhRR	aryl hydrocarbon receptor repressor	57491	57491	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The inhibitory effect of aryl_hydrocarbon_receptor_repressor -LRB- AhRR -RRB- on the growth of human breast_cancer MCF-7 cells .
17949687	0	AhR_repressor	53,66	ANKRA2	77,83	AhR repressor	ANKRA2	57491	57763	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of transcriptional repression of AhR_repressor involving ANKRA2 , HDAC4 , and HDAC5 .
9170146	0	Ah_receptor	6,17	AHR	19,22	Ah receptor	AHR	196	196	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human Ah_receptor -LRB- AHR -RRB- gene : localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility .
14678789	0	Ah_receptor	85,96	AhR	98,101	Ah receptor	AhR	196	196	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphism analysis and functional characterization of the human Ah_receptor -LRB- AhR -RRB- gene promoter .
9778040	0	Ah_receptor	20,31	Ahr	33,36	Ah receptor	Ahr	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of mouse Ah_receptor -LRB- Ahr -RRB- gene basal expression by members of the Sp family of transcription factors .
9744540	0	Ah_receptor	153,164	CYP1B1	14,20	Ah receptor	CYP1B1	196	1545	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure : role of the Ah_receptor .
16399344	0	Ah_receptor	12,23	UDP-glucuronosyltransferase_1A1	46,77	Ah receptor	UDP-glucuronosyltransferase 1A1	196	54658	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Ah_receptor in induction of human UDP-glucuronosyltransferase_1A1 .
2154949	0	Ah_receptor	24,35	aryl_hydrocarbon_hydroxylase	46,74	Ah receptor	aryl hydrocarbon hydroxylase	196	1544	Gene	Gene	mediating|compound|START_ENTITY Characterization|nmod|mediating END_ENTITY|nsubj|Characterization	Characterization of the Ah_receptor mediating aryl_hydrocarbon_hydroxylase induction in the human liver cell line Hep G2 .
2545344	0	Ah_receptor	124,135	aryl_hydrocarbon_hydroxylase	33,61	Ah receptor	aryl hydrocarbon hydroxylase	196	1551	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|lines lines|amod|END_ENTITY	Structure-dependent induction of aryl_hydrocarbon_hydroxylase in human breast_cancer cell lines and characterization of the Ah_receptor .
3011254	0	Ah_receptor	0,11	aryl_hydrocarbon_hydroxylase	35,63	Ah receptor	aryl hydrocarbon hydroxylase	196	1544	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Ah_receptor mediating induction of aryl_hydrocarbon_hydroxylase : detection in human lung by binding of 2,3,7,8 - -LSB- 3H -RSB- tetrachlorodibenzo-p-dioxin .
8244375	0	Ah_receptor_nuclear_translocator	4,36	ARNT	43,47	Ah receptor nuclear translocator	ARNT	405	405	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Ah_receptor_nuclear_translocator gene -LRB- ARNT -RRB- is located on q21 of human chromosome 1 and on mouse chromosome 3 near Cf-3 .
9399571	0	Ah_receptor_nuclear_translocator	64,96	CBP/p300	0,8	Ah receptor nuclear translocator	CBP/p300	405	1387;2033	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	CBP/p300 functions as a possible transcriptional coactivator of Ah_receptor_nuclear_translocator -LRB- Arnt -RRB- .
11129342	0	Ah_receptor_nuclear_translocator	31,63	hARNT	70,75	Ah receptor nuclear translocator	hARNT	405	405	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure of the human Ah_receptor_nuclear_translocator gene -LRB- hARNT -RRB- .
15584899	0	Aha1	0,4	Hop	19,22	Aha1	Hop	10598	10963	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Aha1 competes with Hop , p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone_receptor activation .
15584899	0	Aha1	0,4	Hsp90	75,80	Aha1	Hsp90	10598	3320	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Aha1 competes with Hop , p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone_receptor activation .
23166640	0	Aha1	78,82	Hsp90	32,37	Aha1	Hsp90	851800(Tax:4932)	855836(Tax:4932)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922 .
26235616	0	Aha1	43,47	c-Abl	0,5	Aha1	c-Abl	10598	25	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|amod|END_ENTITY	c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells .
8921887	0	Ahch	0,4	DAX1	29,33	Ahch	DAX1	11614(Tax:10090)	11614(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Ahch , the mouse homologue of DAX1 : cloning , characterization and synteny with GyK , the glycerol kinase locus .
8168479	0	Ahcy	89,93	S-adenosylhomocysteine_hydrolase	55,87	Ahcy	S-adenosylhomocysteine hydrolase	269378(Tax:10090)	269378(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse lethal nonagouti -LRB- a -LRB- x -RRB- -RRB- mutation deletes the S-adenosylhomocysteine_hydrolase -LRB- Ahcy -RRB- gene .
18636121	0	Ahi1	47,51	Huntingtin-associated_protein_1	0,31	Ahi1	Huntingtin-associated protein 1	52906(Tax:10090)	15114(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Huntingtin-associated_protein_1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice .
9778040	0	Ahr	33,36	Ah_receptor	20,31	Ahr	Ah receptor	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of mouse Ah_receptor -LRB- Ahr -RRB- gene basal expression by members of the Sp family of transcription factors .
11577022	0	Ahr	104,107	Cyp1a1	41,47	Ahr	Cyp1a1	11622(Tax:10090)	13076(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY role|nmod|factor expression|dep|role expression|nmod|END_ENTITY	Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells : role of the Ahr bHLH/PAS transcription factor .
25381386	0	Aicda	16,21	IL-10	0,5	Aicda	IL-10	57379	3586	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-10 regulates Aicda expression through miR-155 .
25331797	0	Aid	36,39	SHOX2	12,17	Aid	SHOX2	57379	6474	Gene	Gene	Methylation|nmod|START_ENTITY Methylation|compound|END_ENTITY	Analysis of SHOX2 Methylation as an Aid to Cytology in Lung_Cancer Diagnosis .
9153231	0	Aik	95,98	Ipl1	142,146	Aik	Ipl1	6790	855892(Tax:4932)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase , Aik , related to Aurora of Drosophila and yeast Ipl1 .
26823144	0	Aiolos	0,6	Blimp-1	25,32	Aiolos	Blimp-1	22806	639	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	Aiolos collaborates with Blimp-1 to regulate the survival of multiple_myeloma cells .
10366597	0	Aip1p	0,5	cofilin	21,28	Aip1p	cofilin	855117(Tax:4932)	850676(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Aip1p interacts with cofilin to disassemble actin filaments .
22239103	0	Aire	24,28	DNA-PKcs	0,8	Aire	DNA-PKcs	11634(Tax:10090)	19090(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DNA-PKcs interacts with Aire and regulates the expression of toll-like receptors in RAW264 .7 cells .
26531897	0	Aire	23,27	Jmjd6	42,47	Aire	Jmjd6	11634(Tax:10090)	107817(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY expression|nsubj|regulation expression|nmod|END_ENTITY	Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus .
22540148	0	Aire	0,4	Lin28	63,68	Aire	Lin28	326	79727	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Aire promotes the self-renewal of embryonic stem cells through Lin28 .
10593569	0	Aire	96,100	autoimmune_regulator	69,89	Aire	autoimmune regulator	11634(Tax:10090)	11634(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal localization and complete genomic sequence of the murine autoimmune_regulator gene -LRB- Aire -RRB- .
10940877	0	Aire	68,72	autoimmune_regulator	41,61	Aire	autoimmune regulator	11634(Tax:10090)	11634(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	RNA and protein expression of the murine autoimmune_regulator gene -LRB- Aire -RRB- in normal , RelB-deficient and in NOD mouse .
18214467	0	Aire	76,80	autoimmune_regulator	54,74	Aire	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evolutionarily conserved and divergent regions of the autoimmune_regulator -LRB- Aire -RRB- gene : a comparative analysis .
19615461	0	Aire	34,38	autoimmune_regulator	12,32	Aire	autoimmune regulator	326	326	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of autoimmune_regulator -LRB- Aire -RRB- in the development of the immune system .
21303359	0	Aire	53,57	autoimmune_regulator	31,51	Aire	autoimmune regulator	326	326	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression and function of the autoimmune_regulator -LRB- Aire -RRB- gene in non-thymic tissue .
22396659	0	Airn	113,117	ncRNA	124,129	Airn	ncRNA	100271873	104968399	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter .
13678582	0	Ajuba	55,60	Aurora-A	0,8	Ajuba	Aurora-A	84962	6790	Gene	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	Aurora-A and an interacting activator , the LIM protein Ajuba , are required for mitotic commitment in human cells .
21402878	0	Ajuba	11,16	Aurora-A	27,35	Ajuba	Aurora-A	32351(Tax:7227)	41446(Tax:7227)	Gene	Gene	activator|nsubj|START_ENTITY activator|amod|END_ENTITY	Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome .
11029037	0	Ajuba	0,5	LIM	19,22	Ajuba	LIM	16475(Tax:10090)	56376(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Ajuba , a cytosolic LIM protein , shuttles into the nucleus and affects embryonal cell proliferation and fate decisions .
15728191	0	Ajuba	16,21	p130Cas	33,40	Ajuba	p130Cas	16475(Tax:10090)	12927(Tax:10090)	Gene	Gene	influences|nsubj|START_ENTITY influences|dobj|localization localization|amod|END_ENTITY	The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration .
25686036	0	Akirin2	18,25	Myosin_Heavy_Chain	38,56	Akirin2	Myosin Heavy Chain	100519991	396711(Tax:9823)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	Effect of Porcine Akirin2 on Skeletal Myosin_Heavy_Chain Isoform Expression .
19639604	0	Akt	122,125	AMP-activated_protein_kinase	0,28	Akt	AMP-activated protein kinase	207	5563	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	AMP-activated_protein_kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1 / Akt signaling in C2C12 myotubes .
21613213	0	Akt	14,17	AS160	8,13	Akt	AS160	207	9882	Gene	Gene	substrate|compound|START_ENTITY substrate|compound|END_ENTITY	Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes .
18045951	0	Akt	53,56	Adiponectin	0,11	Akt	Adiponectin	207	9370	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Adiponectin signals in prostate_cancer cells through Akt to activate the mammalian_target_of_rapamycin pathway .
22213475	0	Akt	120,123	Amplified_in_breast_cancer_1	0,28	Akt	Amplified in breast cancer 1	207	63897	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Amplified_in_breast_cancer_1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways .
24098385	0	Akt	100,103	Angiotensin_II	0,14	Akt	Angiotensin II	207	183	Gene	Gene	modulation|nmod|START_ENTITY participation|nmod|modulation END_ENTITY|dep|participation	Angiotensin_II signaling in human preadipose cells : participation of ERK1,2-dependent modulation of Akt .
16894566	0	Akt	68,71	Aurora-A	0,8	Akt	Aurora-A	207	6790	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian_cancer cells .
12691738	0	Akt	76,79	BAD	81,84	Akt	BAD	207	572	Gene	Gene	GSK-3beta|compound|START_ENTITY GSK-3beta|appos|END_ENTITY	Ceramide-induced neuronal_apoptosis is associated with dephosphorylation of Akt , BAD , FKHR , GSK-3beta , and induction of the mitochondrial-dependent intrinsic caspase pathway .
18713867	0	Akt	15,18	BAFF	0,4	Akt	BAFF	11651(Tax:10090)	24099(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells .
18713867	0	Akt	15,18	BAFF-R	35,41	Akt	BAFF-R	11651(Tax:10090)	72049(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells .
14701745	0	Akt	0,3	BID	37,40	Akt	BID	207	637	Gene	Gene	inhibits|compound|START_ENTITY apoptosis|nsubj|inhibits apoptosis|dobj|downstream downstream|nmod|cleavage cleavage|compound|END_ENTITY	Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases .
12351720	0	Akt	69,72	Bcl-2-associated_death_protein	14,44	Akt	Bcl-2-associated death protein	24185(Tax:10116)	64639(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Bcl-2-associated_death_protein and counter-response of Akt within cell populations during seizure-induced neuronal_death .
20187936	0	Akt	0,3	Bid	98,101	Akt	Bid	207	637	Gene	Gene	activity|compound|START_ENTITY protects|nsubj|activity protects|nmod|inhibition inhibition|nmod|cleavage cleavage|compound|END_ENTITY	Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage .
20661217	0	Akt	36,39	Bid	18,21	Akt	Bid	207	637	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian_cancer cells .
22495929	0	Akt	54,57	C/EBP-b	34,41	Akt	C/EBP-b	207	1051	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Negative regulation of miR-145 by C/EBP-b through the Akt pathway in cancer cells .
17343788	0	Akt	30,33	CD8	37,40	Akt	CD8	207	925	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	-LSB- Promotion of the activity of Akt in CD8 + T cells by the crosslink of 3H3 , an agonist antibody of 4-1BB -RSB- .
17548608	0	Akt	109,112	CD8	57,60	Akt	CD8	207	925	Gene	Gene	phosphorylation|compound|START_ENTITY associated|nmod|phosphorylation loss|parataxis|associated loss|nmod|CD28-CD27 CD28-CD27|compound|END_ENTITY	The loss of telomerase activity in highly differentiated CD8 + CD28-CD27 - T cells is associated with decreased Akt -LRB- Ser473 -RRB- phosphorylation .
19406987	0	Akt	34,37	CD8	118,121	Akt	CD8	207	925	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|cells cells|compound|END_ENTITY	KLRG1 signaling induces defective Akt -LRB- ser473 -RRB- phosphorylation and proliferative dysfunction of highly differentiated CD8 + T cells .
22467649	0	Akt	22,25	CD8	36,39	Akt	CD8	207	925	Gene	Gene	effector|compound|START_ENTITY effector|compound|END_ENTITY	Signal integration by Akt regulates CD8 T cell effector and memory differentiation .
21143984	0	Akt	35,38	CKAP4	86,91	Akt	CKAP4	207	10970	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder_carcinoma cells .
15016316	0	Akt	42,45	COX-2	14,19	Akt	COX-2	207	5743	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of COX-2 protein expression by Akt in endometrial_cancer cells is mediated through NF-kappaB/IkappaB pathway .
15067356	0	Akt	0,3	COX-2	14,19	Akt	COX-2	207	4513	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|mRNA mRNA|compound|END_ENTITY	Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial_cancer cells .
16000874	0	Akt	50,53	COX-2	0,5	Akt	COX-2	207	5743	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway inhibits|nmod|activation inhibits|nsubj|END_ENTITY	COX-2 inhibits anoikis by activation of the PI-3K / Akt pathway in human bladder_cancer cells .
16044407	0	Akt	100,103	COX-2	44,49	Akt	COX-2	207	5743	Gene	Gene	transduction|compound|START_ENTITY downregulation|nmod|transduction expression|nmod|downregulation expression|nsubj|Inhibition Inhibition|appos|END_ENTITY	Inhibition of TPA-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin through downregulation of Akt signal transduction in human keratinocytes .
18823436	0	Akt	93,96	COX-2	54,59	Akt	COX-2	207	4513	Gene	Gene	signaling|compound|START_ENTITY effects|nmod|signaling effects|nmod|celecoxib celecoxib|appos|inhibitor inhibitor|compound|END_ENTITY	Anti-gastric_cancer effects of celecoxib , a selective COX-2 inhibitor , through inhibition of Akt signaling .
20446020	0	Akt	103,106	COX-2	51,56	Akt	COX-2	207	5743	Gene	Gene	signaling|nsubj|START_ENTITY suppressing|advcl|signaling inhibits|advcl|suppressing inhibits|dobj|expressions expressions|compound|END_ENTITY	17beta-estradiol inhibits prostaglandin_E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon_cancer cells .
20854947	0	Akt	67,70	COX-2	25,30	Akt	COX-2	11651(Tax:10090)	19225(Tax:10090)	Gene	Gene	transduction|compound|START_ENTITY regulates|dobj|transduction regulates|nsubj|END_ENTITY	Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity .
22214188	0	Akt	30,33	COX-2	86,91	Akt	COX-2	207	4513	Gene	Gene	inhibition|nmod|START_ENTITY modulates|nsubj|inhibition modulates|dobj|expression expression|nmod|END_ENTITY	Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia .
26391397	0	Akt	121,124	Calmodulin	72,82	Akt	Calmodulin	207	808	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Structural and Biophysical Characterization of the Interactions Between Calmodulin and the Pleckstrin Homology Domain of Akt .
23943800	0	Akt	57,60	Carboxyl-terminal_modulator_protein	0,35	Akt	Carboxyl-terminal modulator protein	207	117145	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Carboxyl-terminal_modulator_protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast_cancer .
17942896	0	Akt	47,50	Casein_kinase_2-interacting_protein-1	0,37	Akt	Casein kinase 2-interacting protein-1	207	51177	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Casein_kinase_2-interacting_protein-1 , a novel Akt pleckstrin homology domain-interacting protein , down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo .
19139280	0	Akt	24,27	ClipR-59	0,8	Akt	ClipR-59	207	25999	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization .
23813870	0	Akt	14,17	Cyclin_D1	152,161	Akt	Cyclin D1	11651(Tax:10090)	12443(Tax:10090)	Gene	Gene	play|nsubj|START_ENTITY play|dobj|role role|nmod|proliferation proliferation|nmod|keratinocytes keratinocytes|nmod|modulation modulation|nmod|END_ENTITY	EGFR-mediated Akt and MAPKs signal pathways play a crucial role in patulin-induced cell proliferation in primary murine keratinocytes via modulation of Cyclin_D1 and COX-2 expression .
25802931	0	Akt	0,3	DLK	15,18	Akt	DLK	11651(Tax:10090)	26404(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells .
15678105	0	Akt	54,57	DNA-PKcs	0,8	Akt	DNA-PKcs	11651(Tax:10090)	19090(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	DNA-PKcs , but not TLR9 , is required for activation of Akt by CpG-DNA .
25152407	0	Akt	26,29	DNA-PKcs	0,8	Akt	DNA-PKcs	207	5591	Gene	Gene	activation|compound|START_ENTITY important|nmod|activation important|nsubj|END_ENTITY	DNA-PKcs is important for Akt activation and gemcitabine resistance in PANC-1 pancreatic_cancer cells .
24365180	0	Akt	112,115	DNA-dependent_protein_kinase_catalytic_subunit	0,46	Akt	DNA-dependent protein kinase catalytic subunit	207	5591	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|dep|phosphorylation	DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- - SIN1 association mediates ultraviolet B -LRB- UVB -RRB- - induced Akt Ser-473 phosphorylation and skin cell survival .
25253241	0	Akt	0,3	Dab2	13,17	Akt	Dab2	207	1601	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Akt recruits Dab2 to albumin endocytosis in the proximal tubule .
23462102	0	Akt	0,3	Dock6	74,79	Akt	Dock6	11651(Tax:10090)	319899(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Akt and PP2A reciprocally regulate the guanine_nucleotide exchange factor Dock6 to control axon growth of sensory neurons .
15969343	0	Akt	33,36	E-cadherin	15,25	Akt	E-cadherin	207	999	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	-LSB- Regulation of E-cadherin by the Akt protein kinase B -RSB- .
15187102	0	Akt	30,33	E2F-1	63,68	Akt	E2F-1	207	1869	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin_A in breast_cancer cells .
12485852	0	Akt	52,55	ERK	14,17	Akt	ERK	11651(Tax:10090)	26413(Tax:10090)	Gene	Gene	Rac1|nmod|START_ENTITY controlled|nmod|Rac1 Activation|acl|controlled Activation|nmod|END_ENTITY	Activation of ERK , controlled by Rac1 and Cdc42 via Akt , is required for anoikis .
15056728	0	Akt	96,99	ERK	69,72	Akt	ERK	24185(Tax:10116)	24338(Tax:10116)	Gene	Gene	extracellular_signal-regulated_protein_kinase|appos|START_ENTITY extracellular_signal-regulated_protein_kinase|appos|END_ENTITY	In vivo regulation of extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- and protein kinase B -LRB- Akt -RRB- phosphorylation by acute and chronic morphine .
15115658	0	Akt	90,93	ERK	96,99	Akt	ERK	207	2048	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase / Akt - , ERK - , and Src family kinase-dependent pathway .
15857394	0	Akt	39,42	ERK	84,87	Akt	ERK	207	5594	Gene	Gene	activation|nmod|START_ENTITY couple|nmod|activation couple|appos|END_ENTITY	5-HT receptors couple to activation of Akt , but not extracellular-regulated_kinase -LRB- ERK -RRB- , in cultured hippocampal neurons .
16885155	0	Akt	96,99	ERK	0,3	Akt	ERK	207	5594	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	ERK promotes hydrogen_peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells .
18256541	0	Akt	0,3	ERK	16,19	Akt	ERK	207	5594	Gene	Gene	inactivates|compound|START_ENTITY END_ENTITY|nsubj|inactivates	Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells .
20816750	0	Akt	132,135	ERK	137,140	Akt	ERK	207	5594	Gene	Gene	v|dep|START_ENTITY v|appos|END_ENTITY	Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin a -LRB- 5 -RRB- b -LRB- 1 -RRB- / a -LRB- v -RRB- b -LRB- 3 -RRB- - dependent Akt , ERK and JNK signaling pathways in human umbilical vein endothelial cells .
22147269	0	Akt	68,71	ERK	54,57	Akt	ERK	24185(Tax:10116)	24338(Tax:10116)	Gene	Gene	confer|nsubj|START_ENTITY Upregulation|parataxis|confer Upregulation|nmod|END_ENTITY	Upregulation of heme_oxygenase-1 by acteoside through ERK and PI3_K / Akt pathway confer neuroprotection against beta-amyloid-induced neurotoxicity .
24088818	0	Akt	94,97	ERK	99,102	Akt	ERK	207	5594	Gene	Gene	Src|compound|START_ENTITY Src|appos|END_ENTITY	ErbB2 upregulates the Na + , HCO3 -LRB- - -RRB- - cotransporter NBCn1/SLC4A7 in human breast_cancer cells via Akt , ERK , Src , and Kruppel-like factor 4 .
26821209	0	Akt	120,123	ERK	145,148	Akt	ERK	207	5594	Gene	Gene	/|compound|START_ENTITY induced|dep|/ induced|dobj|pathways pathways|compound|END_ENTITY	Long chain n-3 polyunsaturated_fatty_acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKC / - induced ERK pathways .
17942284	0	Akt	110,113	ERK1/2	93,99	Akt	ERK1/2	207	5595;5594	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	HGF protects cultured cortical neurons against hypoxia/reoxygenation induced cell injury via ERK1/2 and PI-3K / Akt pathways .
24650887	0	Akt	214,217	ERK1/2	194,200	Akt	ERK1/2	11651(Tax:10090)	26417;26413	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
16642037	0	Akt	8,11	Ebp1	47,51	Akt	Ebp1	24185(Tax:10116)	81736(Tax:10116)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Nuclear Akt associates with PKC-phosphorylated Ebp1 , preventing DNA fragmentation by inhibition of caspase-activated_DNase .
25140997	0	Akt	116,119	Epac-1	109,115	Akt	Epac-1	24185(Tax:10116)	59326(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|dep|END_ENTITY	The GLP-1 Analogue Liraglutide Protects Cardiomyocytes from High Glucose-induced Apoptosis by Activating the Epac-1 / Akt Pathway .
26508828	0	Akt	43,46	Epidermal_Growth_Factor_Receptor	96,128	Akt	Epidermal Growth Factor Receptor	207	1956	Gene	Gene	Protein_Kinase_B|appos|START_ENTITY Protein_Kinase_B|nmod|Individuals Individuals|nmod|Associated Associated|nmod|END_ENTITY	Decreased Phosphorylated Protein_Kinase_B -LRB- Akt -RRB- in Individuals with Autism Associated with High Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- and Low Gamma-Aminobutyric_Acid -LRB- GABA -RRB- .
18813952	0	Akt	69,72	Epidermal_growth_factor_receptor	0,32	Akt	Epidermal growth factor receptor	207	1956	Gene	Gene	pathways|compound|START_ENTITY status|nmod|pathways status|amod|END_ENTITY	Epidermal_growth_factor_receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon_cancer cell lines .
19002495	0	Akt	94,97	Epidermal_growth_factor_receptor	0,32	Akt	Epidermal growth factor receptor	207	1956	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Epidermal_growth_factor_receptor mutations in non-small_cell_lung_cancer influence downstream Akt , MAPK and Stat3 signaling .
21822299	0	Akt	117,120	ErbB-3	110,116	Akt	ErbB-3	207	2065	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	An ErbB-3 antibody , MP-RM-1 , inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3 / Akt signaling .
21822299	0	Akt	117,120	ErbB-3	3,9	Akt	ErbB-3	207	2065	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling blocking|dobj|activation inhibits|advcl|blocking inhibits|nsubj|antibody antibody|compound|END_ENTITY	An ErbB-3 antibody , MP-RM-1 , inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3 / Akt signaling .
17217721	0	Akt	151,154	Erythropoietin	1,15	Akt	Erythropoietin	24185(Tax:10116)	24335(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY model|nmod|-RSB- enhances|nmod|model enhances|nsubj|END_ENTITY	-LSB- Erythropoietin enhances the therapy potency of autologous bone marrow stromal cells in a rat heart_infarction model via phosphatidylinositol-3-kinase / Akt pathway -RSB- .
17498671	0	Akt	56,59	FGF-2	15,20	Akt	FGF-2	207	2247	Gene	Gene	stimulating|dobj|START_ENTITY Interaction|acl|stimulating Interaction|nmod|END_ENTITY	Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt , ERK , and neuronal survival in hippocampal cultures .
10602488	0	Akt	123,126	FKHR	48,52	Akt	FKHR	207	2308	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the forkhead transcription factor FKHR , but not the PAX3-FKHR fusion protein , by the serine/threonine kinase Akt .
12456685	0	Akt	0,3	FKHR	55,59	Akt	FKHR	207	2308	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Akt modulates STAT3-mediated gene expression through a FKHR -LRB- FOXO1a -RRB- - dependent mechanism .
12691738	0	Akt	76,79	FKHR	86,90	Akt	FKHR	207	2308	Gene	Gene	GSK-3beta|compound|START_ENTITY GSK-3beta|appos|END_ENTITY	Ceramide-induced neuronal_apoptosis is associated with dephosphorylation of Akt , BAD , FKHR , GSK-3beta , and induction of the mitochondrial-dependent intrinsic caspase pathway .
14662022	0	Akt	27,30	FLIP	16,20	Akt	FLIP	207	8837	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of FLIP -LRB- S -RRB- by Akt , a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric_cancers .
15985761	0	Akt	100,103	FLIP	139,143	Akt	FLIP	207	8837	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|form form|nmod|END_ENTITY	TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol_3-kinase / Akt through the short form of cellular FLIP and Bcl-2 .
16670089	0	Akt	76,79	FOXO1	126,131	Akt	FOXO1	207	2308	Gene	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1 .
17079231	0	Akt	87,90	FOXO3a	77,83	Akt	FOXO3a	24185(Tax:10116)	294515(Tax:10116)	Gene	Gene	dismutase|nmod|START_ENTITY dismutase|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats .
18385518	0	Akt	154,157	FOXO3a	86,92	Akt	FOXO3a	207	2309	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Endothelin-1 couples betaPix to p66Shc : role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt .
18644865	0	Akt	77,80	FOXO3a	34,40	Akt	FOXO3a	207	2309	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	The forkhead transcription factor FOXO3a increases phosphoinositide-3_kinase / Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression .
24337611	0	Akt	109,112	FOXO3a	83,89	Akt	FOXO3a	207	2309	Gene	Gene	inactivation|nmod|START_ENTITY inhibits|nmod|inactivation inhibits|nmod|activation activation|nmod|END_ENTITY	Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular_carcinoma .
26375988	0	Akt	90,93	FOXO3a	61,67	Akt	FOXO3a	207	2309	Gene	Gene	inhibition|compound|START_ENTITY translocation|nmod|inhibition END_ENTITY|acl|translocation	Methylseleninic_acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition .
15688030	0	Akt	37,40	FOXO4	22,27	Akt	FOXO4	207	4303	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Constitutively active FOXO4 inhibits Akt activity , regulates p27_Kip1 stability , and suppresses HER2-mediated tumorigenicity .
11756562	0	Akt	15,18	Fas_ligand	37,47	Akt	Fas ligand	207	356	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Suppression of Akt signaling induces Fas_ligand expression : involvement of caspase and Jun_kinase activation in Akt-mediated Fas_ligand regulation .
25944616	0	Akt	29,32	Filamin_A	0,9	Akt	Filamin A	207	2316	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Filamin_A phosphorylation by Akt promotes cell migration in response to arsenic .
25944616	0	Akt	29,32	Filamin_A	0,9	Akt	Filamin A	207	2316	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Filamin_A phosphorylation by Akt promotes cell migration in response to arsenic .
11570877	0	Akt	124,127	Fkhr	87,91	Akt	Fkhr	207	2308	Gene	Gene	distinct|nmod|START_ENTITY requires|xcomp|distinct requires|nsubj|regulation regulation|nmod|expression expression|nmod|Foxo1 Foxo1|appos|END_ENTITY	Insulin regulation of gene expression through the forkhead transcription factor Foxo1 -LRB- Fkhr -RRB- requires kinases distinct from Akt .
15166238	0	Akt	67,70	Focal_adhesion_kinase	0,21	Akt	Focal adhesion kinase	207	5747	Gene	Gene	I|dep|START_ENTITY phosphatidylinositol_3-kinase|dep|I matrices|amod|phosphatidylinositol_3-kinase upstream|nmod|matrices signaling|advmod|upstream signaling|nsubj|END_ENTITY	Focal_adhesion_kinase is upstream of phosphatidylinositol_3-kinase / Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway .
18854312	0	Akt	71,74	Focal_adhesion_kinase	0,21	Akt	Focal adhesion kinase	207	5747	Gene	Gene	protection|compound|START_ENTITY mediating|dobj|protection scaffold|xcomp|mediating scaffold|nsubj|END_ENTITY	Focal_adhesion_kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection .
16203862	0	Akt	48,51	FoxO1	103,108	Akt	FoxO1	207	2308	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	PGC-1alpha gene expression is down-regulated by Akt - mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle .
18458087	0	Akt	0,3	FoxO3a	77,83	Akt	FoxO3a	207	2309	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|survival survival|nmod|cells cells|nmod|inhibition inhibition|nmod|END_ENTITY	Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3 .
20223831	0	Akt	77,80	FoxO3a	47,53	Akt	FoxO3a	207	2309	Gene	Gene	coordination|nmod|START_ENTITY suppresses|nmod|coordination suppresses|dobj|END_ENTITY	beta1-Integrin-collagen interaction suppresses FoxO3a by the coordination of Akt and PP2A .
23390247	0	Akt	21,24	Foxo3a	50,56	Akt	Foxo3a	207	2309	Gene	Gene	inactivation|nmod|START_ENTITY signals|nsubj|inactivation signals|dobj|translocation translocation|amod|END_ENTITY	Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation , TRAIL gene induction , and potent antitumor effects .
10688821	0	Akt	14,17	G-CSF	67,72	Akt	G-CSF	207	1440	Gene	Gene	Activation|nmod|START_ENTITY kinase|dep|Activation kinase|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|appos|END_ENTITY	Activation of Akt kinase by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- : evidence for the role of a tyrosine kinase activity distinct from the Janus kinases .
23645209	0	Akt	22,25	GAPDH	0,5	Akt	GAPDH	207	2597	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	GAPDH binds to active Akt , leading to Bcl-xL increase and escape from caspase-independent cell death .
9415393	0	Akt	22,25	GLUT4	65,70	Akt	GLUT4	24185(Tax:10116)	25139(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|translocation translocation|nmod|END_ENTITY	Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells .
22999562	0	Akt	62,65	GSK-3b	47,53	Akt	GSK-3b	207	2932	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Regulation of glycogen_synthase_kinase-3_beta -LRB- GSK-3b -RRB- by the Akt pathway in gliomas .
23010592	0	Akt	84,87	GSK-3b	25,31	Akt	GSK-3b	207	2932	Gene	Gene	phosphorylation|nmod|START_ENTITY Ser9|acl|phosphorylation Ser9|amod|END_ENTITY	NOK/STYK1 interacts with GSK-3b and mediates Ser9 phosphorylation through activated Akt .
24504086	0	Akt	0,3	GSK-3b	13,19	Akt	GSK-3b	24185(Tax:10116)	84027(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Akt mediates GSK-3b phosphorylation in the rat prefrontal cortex during the process of ketamine exerting rapid antidepressant actions .
19389373	0	Akt	0,3	GSK3	43,47	Akt	GSK3	11651(Tax:10090)	56637(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Akt regulates skeletal development through GSK3 , mTOR , and FoxOs .
24726471	0	Akt	59,62	G_protein-coupled_estrogen_receptor_1	21,58	Akt	G protein-coupled estrogen receptor 1	11651(Tax:10090)	76854(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Raloxifene activates G_protein-coupled_estrogen_receptor_1 / Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine mice .
23376640	0	Akt	108,111	Gastrin	0,7	Akt	Gastrin	207	2520	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Gastrin acting on the cholecystokinin2_receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K / Akt pathway in human gastric_cancer cells .
17349623	0	Akt	36,39	Gastrin-releasing_peptide	0,25	Akt	Gastrin-releasing peptide	207	2922	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Gastrin-releasing_peptide activates Akt through the epidermal_growth_factor_receptor pathway and abrogates the effect of gefitinib .
17431186	0	Akt	22,25	Glutaredoxin	0,12	Akt	Glutaredoxin	207	2745	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione_reductase-dependent manner .
20488185	0	Akt	71,74	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	Akt	Glyceraldehyde-3-phosphate dehydrogenase	24185(Tax:10116)	24383(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle .
11809791	0	Akt	56,59	Grb10	29,34	Akt	Grb10	11651(Tax:10090)	14783(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Role for the adaptor protein Grb10 in the activation of Akt .
11960368	0	Akt	27,30	HDM2	19,23	Akt	HDM2	207	4193	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of HDM2 by Akt .
16928826	0	Akt	16,19	HER-3	95,100	Akt	HER-3	207	2065	Gene	Gene	Inactivation|nmod|START_ENTITY mediated|nsubjpass|Inactivation mediated|nmod|END_ENTITY	Inactivation of Akt by the epidermal_growth_factor_receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal_tumor cell lines and contributes to erlotinib sensitivity .
14612949	0	Akt	14,17	HER2/neu	0,8	Akt	HER2/neu	207	2064	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	HER2/neu uses Akt to suppress retinoic_acid response element binding activity in MDA-MB-453 breast_cancer cells .
25695729	0	Akt	137,140	HIF-1a	13,19	Akt	HIF-1a	207	3091	Gene	Gene	activation|nmod|START_ENTITY downregulating|dobj|activation inhibit|advcl|downregulating blocks|advcl|inhibit blocks|dobj|expression expression|compound|END_ENTITY	SOCS3 blocks HIF-1a expression to inhibit proliferation and angiogenesis of human small_cell_lung_cancer by downregulating activation of Akt , but not STAT3 .
26319392	0	Akt	51,54	HMGA2	10,15	Akt	HMGA2	207	8091	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML .
24469056	0	Akt	0,3	HSF-1	33,38	Akt	HSF-1	207	3297	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt phosphorylates and activates HSF-1 independent of heat_shock , leading to Slug overexpression and epithelial-mesenchymal transition -LRB- EMT -RRB- of HER2-overexpressing breast_cancer cells .
15848222	0	Akt	0,3	HSP27	31,36	Akt	HSP27	24185(Tax:10116)	24471(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells : function at a point downstream from p38 MAP kinase .
15896702	0	Akt	54,57	HSP27	96,101	Akt	HSP27	24185(Tax:10116)	24471(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY signal|nsubj|involvement signal|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Possible involvement of phosphatidylinositol_3-kinase / Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells .
16514645	0	Akt	30,33	HSP27	85,90	Akt	HSP27	11651(Tax:10090)	15507(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|induction induction|compound|END_ENTITY	Phosphatidylinositol_3-kinase / Akt plays a role in sphingosine_1-phosphate-stimulated HSP27 induction in osteoblasts .
15862750	0	Akt	10,13	Hdm2	65,69	Akt	Hdm2	207	4193	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Activated Akt expression in breast_cancer : correlation with p53 , Hdm2 and patient outcome .
20018937	0	Akt	47,50	Heat_shock_cognate_protein_70	0,29	Akt	Heat shock cognate protein 70	207	3312	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Heat_shock_cognate_protein_70 is essential for Akt signaling in endothelial function .
11003625	0	Akt	115,118	Hepatocyte_growth_factor	0,24	Akt	Hepatocyte growth factor	207	3082	Gene	Gene	activation|compound|START_ENTITY cells|nmod|activation death|nmod|cells promotes|nmod|death promotes|nsubj|END_ENTITY	Hepatocyte_growth_factor promotes cell survival from fas-mediated cell death in hepatocellular_carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression .
15522281	0	Akt	85,88	Hepatocyte_growth_factor	0,24	Akt	Hepatocyte growth factor	11651(Tax:10090)	15234(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY prevents|nmod|mice prevents|nsubj|END_ENTITY	Hepatocyte_growth_factor prevents ventricular_remodeling_and_dysfunction in mice via Akt pathway and angiogenesis .
17412827	0	Akt	70,73	Hepatocyte_growth_factor	0,24	Akt	Hepatocyte growth factor	11651(Tax:10090)	15234(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regeneration|nmod|signaling promotes|dobj|regeneration promotes|nsubj|END_ENTITY	Hepatocyte_growth_factor promotes colonic epithelial regeneration via Akt signaling .
18262389	0	Akt	114,117	Hepatocyte_growth_factor	0,24	Akt	Hepatocyte growth factor	207	3082	Gene	Gene	pathway|compound|START_ENTITY differentiation|nmod|pathway promote|nmod|differentiation promote|nsubj|END_ENTITY	Hepatocyte_growth_factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway .
21744257	0	Akt	132,135	Hepatocyte_growth_factor	0,24	Akt	Hepatocyte growth factor	11651(Tax:10090)	15234(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY carcinogenesis|nmod|pathways promotes|dobj|carcinogenesis promotes|nsubj|upregulation upregulation|compound|END_ENTITY	Hepatocyte_growth_factor upregulation promotes carcinogenesis and epithelial-mesenchymal_transition_in_hepatocellular_carcinoma via Akt and COX-2 pathways .
18562319	0	Akt	119,122	Heterogeneous_nuclear_ribonucleoprotein_A1	0,42	Akt	Heterogeneous nuclear ribonucleoprotein A1	207	3178	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|nsubj|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_A1 regulates cyclin_D1 and c-myc internal ribosome entry site function through Akt signaling .
17510053	0	Akt	16,19	Hsp27	0,5	Akt	Hsp27	207	3315	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex .
17510053	0	Akt	95,98	Hsp27	0,5	Akt	Hsp27	207	3315	Gene	Gene	scaffolding|xcomp|START_ENTITY regulates|advcl|scaffolding regulates|nsubj|END_ENTITY	Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex .
20858736	0	Akt	65,68	Hsp27	0,5	Akt	Hsp27	207	3315	Gene	Gene	apoptosis|nmod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	Hsp27 protects adenocarcinoma cells from UV-induced apoptosis by Akt and p21-dependent pathways of survival .
12062094	0	Akt	10,13	IGF-1	4,9	Akt	IGF-1	207	3479	Gene	Gene	neuroprotective|nsubj|START_ENTITY END_ENTITY|parataxis|neuroprotective	The IGF-1 / Akt pathway is neuroprotective in Huntington 's _ disease and involves Huntingtin phosphorylation by Akt .
12173037	0	Akt	96,99	IGF-1	90,95	Akt	IGF-1	207	3479	Gene	Gene	Activation|parataxis|START_ENTITY Activation|nmod|proteins proteins|nmod|END_ENTITY	Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1 / Akt signaling in human multiple_myeloma cells : therapeutic implications .
16792806	0	Akt	79,82	IGF-1	30,35	Akt	IGF-1	24185(Tax:10116)	24482(Tax:10116)	Gene	Gene	activation/phosphorylation|nmod|START_ENTITY induces|dobj|activation/phosphorylation induces|nsubj|Insulin-like_growth_factor-1 Insulin-like_growth_factor-1|appos|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- induces the activation/phosphorylation of Akt kinase and cAMP_response_element-binding_protein -LRB- CREB -RRB- by activating different signaling pathways in PC12 cells .
17498671	0	Akt	56,59	IGF-1	26,31	Akt	IGF-1	207	3479	Gene	Gene	stimulating|dobj|START_ENTITY Interaction|acl|stimulating Interaction|nmod|END_ENTITY	Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt , ERK , and neuronal survival in hippocampal cultures .
22394561	0	Akt	0,3	IGF-1	97,102	Akt	IGF-1	207	3479	Gene	Gene	control|nsubj|START_ENTITY control|dobj|response response|nmod|cells cells|nmod|END_ENTITY	Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2 .
23472139	0	Akt	14,17	IGF-1	76,81	Akt	IGF-1	207	3479	Gene	Gene	products|amod|START_ENTITY Activation|nmod|products Activation|dep|involvement involvement|nmod|receptor receptor|compound|END_ENTITY	Activation of Akt by advanced glycation end products -LRB- AGEs -RRB- : involvement of IGF-1 receptor and caveolin-1 .
26280404	0	Akt	83,86	IGF-1	77,82	Akt	IGF-1	11651(Tax:10090)	16000(Tax:10090)	Gene	Gene	signal|compound|START_ENTITY Reversal|dep|signal Reversal|nmod|END_ENTITY	Reversal of muscle_atrophy by Zhimu and Huangbai herb pair via activation of IGF-1 / Akt and autophagy signal in cancer_cachexia .
17602833	0	Akt	126,129	IGF-II	101,107	Akt	IGF-II	207	3481	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The hedgehog pathway inhibitor cyclopamine increases levels of p27 , and decreases both expression of IGF-II and activation of Akt in PC-3_prostate_cancer cells .
23607268	0	Akt	18,21	IGF-IR	36,42	Akt	IGF-IR	207	3480	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Decorin activates Akt downstream of IGF-IR and promotes myoblast differentiation .
11777539	0	Akt	56,59	IL-10	0,5	Akt	IL-10	207	3586	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	IL-10 promotes survival of microglia without activating Akt .
21949832	0	Akt	0,3	IL-10	14,19	Akt	IL-10	24185(Tax:10116)	25325(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|suppression suppression|compound|END_ENTITY	Akt regulates IL-10 mediated suppression of TNFa-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation .
24650887	0	Akt	214,217	IL-6	138,142	Akt	IL-6	11651(Tax:10090)	16193(Tax:10090)	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY secretion|amod|p-c-JUN_and_JNK secretion|compound|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
24412633	0	Akt	45,48	IL-8	28,32	Akt	IL-8	207	3576	Gene	Gene	activate|dobj|START_ENTITY END_ENTITY|xcomp|activate	Kidney_cancer cells secrete IL-8 to activate Akt and promote migration of mesenchymal stem cells .
22820890	0	Akt	110,113	IRS-1	104,109	Akt	IRS-1	207	3667	Gene	Gene	signaling|nsubj|START_ENTITY ameliorates|parataxis|signaling ameliorates|acl|impaired impaired|xcomp|overexpressing overexpressing|nmod|END_ENTITY	a-Lipoic_acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1 / Akt signaling pathway .
23639858	0	Akt	137,140	IRS-1	131,136	Akt	IRS-1	11651(Tax:10090)	16367(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Paraoxonase1 -LRB- PON1 -RRB- reduces insulin resistance in mice fed a high-fat diet , and promotes GLUT4 overexpression in myocytes , via the IRS-1 / Akt pathway .
22245935	0	Akt	94,97	Id1	18,21	Akt	Id1	207	3397	Gene	Gene	pathway|compound|START_ENTITY growth|nmod|pathway inhibits|dobj|growth inhibits|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of Id1 by small interfering RNA in gastric_cancer inhibits cell growth via the Akt pathway .
12895435	0	Akt	118,121	Insulin	0,7	Akt	Insulin	207	3630	Gene	Gene	role|nmod|START_ENTITY expression|dep|role enhances|dobj|expression enhances|nsubj|END_ENTITY	Insulin enhances the expression of the endothelial_nitric_oxide_synthase in native endothelial cells : a dual role for Akt and AP-1 .
19318457	0	Akt	60,63	Insulin	0,7	Akt	Insulin	207	3630	Gene	Gene	pathway|compound|START_ENTITY factor-I|dep|pathway attenuates|dobj|factor-I attenuates|nsubj|END_ENTITY	Insulin attenuates the insulin-like growth factor-I -LRB- IGF-I -RRB- - Akt pathway , not IGF-I-extracellularly regulated kinase pathway , in luteinized granulosa cells with an increase in PTEN .
21871446	0	Akt	86,89	Insulin	0,7	Akt	Insulin	207	3630	Gene	Gene	cells|nmod|START_ENTITY stimulates|nmod|cells stimulates|nsubj|END_ENTITY	Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt .
26465605	0	Akt	0,3	Insulin	10,17	Akt	Insulin	207	3630	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Akt Links Insulin Signaling to Albumin Endocytosis in Proximal Tubule Epithelial Cells .
12727445	0	Akt	83,86	Interleukin-1_beta	0,18	Akt	Interleukin-1 beta	207	3553	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Interleukin-1_beta protects neurons via the interleukin-1 -LRB- IL-1 -RRB- receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo .
18309287	0	Akt	53,56	Interleukin-2	0,13	Akt	Interleukin-2	207	3558	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS .
15998322	0	Akt	0,3	JFC1	73,77	Akt	JFC1	207	84958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation .
16132952	0	Akt	131,134	JNK	100,103	Akt	JNK	207	5599	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Nitric_oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt .
18402055	0	Akt	53,56	JNK	16,19	Akt	JNK	24185(Tax:10116)	116554(Tax:10116)	Gene	Gene	suppressed|nmod|START_ENTITY suppressed|nsubj|activation activation|compound|END_ENTITY	Ethanol-induced JNK activation suppressed via active Akt in hepatocytes .
19526300	0	Akt	124,127	JNK	155,158	Akt	JNK	24185(Tax:10116)	116554(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY activation|nmod|pathway Protection|nmod|activation Protection|nmod|kinases kinases|compound|END_ENTITY	Protection against chronic hypoperfusion-induced retinal_neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases .
19768546	0	Akt	103,106	JNK	141,144	Akt	JNK	207	5599	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK .
24820448	0	Akt	82,85	JNK	120,123	Akt	JNK	207	5599	Gene	Gene	kinase|dobj|START_ENTITY kinase|dobj|END_ENTITY	Human cord blood stem cell paracrine factors activate the survival protein kinase Akt and inhibit death protein kinases JNK and p38 in injured cardiomyocytes .
25275048	0	Akt	111,114	JNK	14,17	Akt	JNK	207	5599	Gene	Gene	phosphorylation|compound|START_ENTITY suppression|nmod|phosphorylation cells|nmod|suppression potentiates|nmod|cells potentiates|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of JNK potentiates temozolomide-induced cytotoxicity in U87MG glioblastoma cells via suppression of Akt phosphorylation .
12130510	0	Akt	26,29	Jak1	54,58	Akt	Jak1	207	3716	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Functional involvement of Akt signaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells .
24156551	0	Akt	57,60	KCTD20	0,6	Akt	KCTD20	207	222658	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	KCTD20 , a relative of BTBD10 , is a positive regulator of Akt .
25377663	0	Akt	93,96	Klotho	19,25	Akt	Klotho	207	9365	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation .
25573451	0	Akt	105,108	Klotho	31,37	Akt	Klotho	24185(Tax:10116)	83504(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY downregulation|nmod|phosphorylation hypoxia/reoxygenation|nmod|downregulation -RSB-|nmod|hypoxia/reoxygenation -RSB-|dobj|role role|nmod|END_ENTITY	-LSB- Retracted -RSB- Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation .
25855833	1	Akt	105,108	Klotho	31,37	Akt	Klotho	207	9365	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation .
26932461	0	Akt	0,3	LARP6	32,37	Akt	LARP6	207	55323	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Akt mediated phosphorylation of LARP6 ; critical step in biosynthesis of type I collagen .
12411472	0	Akt	50,53	Leptin	0,6	Akt	Leptin	207	3952	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Leptin induces endothelial cell migration through Akt , which is inhibited by PPARgamma-ligands .
17660512	0	Akt	57,60	Leptin	0,6	Akt	Leptin	11651(Tax:10090)	16846(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Leptin induces CD40 expression through the activation of Akt in murine dendritic cells .
25989537	0	Akt	140,143	Leptin	0,6	Akt	Leptin	207	3952	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|parataxis|Pathway	Leptin and Neutrophil-Activating_Peptide_2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol_3-Kinase / Akt Pathway in Patients With Systemic Lupus Erythematosus .
11042204	0	Akt	97,100	MAPKAPK-2	21,30	Akt	MAPKAPK-2	207	9261	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils .
26488172	0	Akt	88,91	MCP-1	40,45	Akt	MCP-1	207	6347	Gene	Gene	Activation|nmod|START_ENTITY Expression|nmod|Activation Expression|compound|END_ENTITY	sPLA2-IIA Augments Oxidized LDL-Induced MCP-1 Expression in Vitro Through Activation of Akt .
18356162	0	Akt	36,39	MDMX	19,23	Akt	MDMX	207	4194	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding .
21405945	0	Akt	50,53	MGMT	68,72	Akt	MGMT	207	4255	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells .
22100392	0	Akt	39,42	MKP3	0,4	Akt	MKP3	11651(Tax:10090)	67603(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis .
20201953	0	Akt	0,3	MMP1	28,32	Akt	MMP1	207	4312	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts .
20233453	0	Akt	0,3	MafK	32,36	Akt	MafK	24185(Tax:10116)	246760(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Akt regulates the expression of MafK , synaptotagmin_I , and syntenin-1 , which play roles_in_neuronal_function .
17878402	0	Akt	88,91	Mammalian_target_of_rapamycin	0,29	Akt	Mammalian target of rapamycin	207	2475	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|inhibition inhibition|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition activates phosphatidylinositol_3-kinase / Akt by up-regulating insulin-like_growth_factor-1 receptor signaling in acute_myeloid_leukemia : rationale for therapeutic inhibition of both pathways .
22268450	0	Akt	128,131	Mcl-1	164,169	Akt	Mcl-1	207	4170	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Epstein-Barr_virus latent membrane protein-1 protects B-cell_lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1 .
12145204	0	Akt	81,84	Mdm2	93,97	Akt	Mdm2	207	4193	Gene	Gene	androgen_receptor|nmod|START_ENTITY ubiquitylation|nmod|androgen_receptor require|nsubj|ubiquitylation require|xcomp|ligase ligase|nsubj|E3 E3|compound|END_ENTITY	Phosphorylation-dependent ubiquitylation and degradation of androgen_receptor by Akt require Mdm2 E3 ligase .
17107963	1	Akt	111,114	Mdm2	68,72	Akt	Mdm2	24185(Tax:10116)	314856(Tax:10116)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Mdm2 is activated in response to inhibited Akt signaling .
26617770	0	Akt	82,85	MicroRNA-133b	0,13	Akt	MicroRNA-133b	207	442890	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MicroRNA-133b inhibits proliferation and invasion of ovarian_cancer cells through Akt and Erk1/2 inactivation by targeting epidermal_growth_factor_receptor .
15890643	0	Akt	247,250	MyD88	108,113	Akt	MyD88	24185(Tax:10116)	301059(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY expression|dep|factor expression|nmod|cells cells|nmod|receptor-associated receptor-associated|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
12879015	0	Akt	55,58	NF-kappaB	16,25	Akt	NF-kappaB	207	4790	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Inactivation Inactivation|nmod|END_ENTITY	Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast_cancer cells .
14580677	0	Akt	21,24	NF-kappaB	0,9	Akt	NF-kappaB	11651(Tax:10090)	18033(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	NF-kappaB stimulates Akt phosphorylation and gene expression by distinct signaling mechanisms .
16199483	0	Akt	81,84	NF-kappaB	29,38	Akt	NF-kappaB	11651(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY associated|nmod|activation associated|nsubjpass|Cardioprotection Cardioprotection|acl|afforded afforded|nmod|ablation ablation|amod|END_ENTITY	Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha .
16450077	0	Akt	97,100	NF-kappaB	104,113	Akt	NF-kappaB	207	4790	Gene	Gene	_|compound|START_ENTITY operates|nmod|_ operates|parataxis|signalling signalling|nsubj|END_ENTITY	The antiatherogenic and antiinflammatory effect of HDL-associated lysosphingolipids operates via Akt _ -- > NF-kappaB signalling pathways in human vascular endothelial cells .
16543232	0	Akt	34,37	NF-kappaB	39,48	Akt	NF-kappaB	207	4790	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation and cross-talk between Akt , NF-kappaB , and unfolded protein response signaling in 1-LN prostate_cancer cells consequent to ligation of cell surface-associated GRP78 .
20619327	0	Akt	43,46	NF-kappaB	48,57	Akt	NF-kappaB	207	4790	Gene	Gene	formation|appos|START_ENTITY END_ENTITY|nsubj|formation	Hexavalent_chromium induced ROS formation , Akt , NF-kappaB , and MAPK activation , and TNF-alpha and IL-1alpha production in keratinocytes .
10984605	0	Akt	13,16	NF-kappa_B	51,61	Akt	NF-kappa B	207	4790	Gene	Gene	phosphorylation|compound|START_ENTITY activate|nsubj|phosphorylation activate|dobj|END_ENTITY	PDGF-induced Akt phosphorylation does not activate NF-kappa_B in human vascular smooth_muscle_cells and fibroblasts .
11259436	0	Akt	0,3	NF-kappa_B	72,82	Akt	NF-kappa B	207	4790	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|potential potential|nmod|Subunit Subunit|nmod|p38 p38|amod|END_ENTITY	Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa_B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38 .
11976320	0	Akt	132,135	NF-kappa_B	41,51	Akt	NF-kappa B	207	4790	Gene	Gene	activation|compound|START_ENTITY occurs|nmod|activation occurs|nsubj|Inhibition Inhibition|nmod|interleukin-1beta interleukin-1beta|acl|induced induced|dobj|activation activation|amod|END_ENTITY	Inhibition of interleukin-1beta - induced NF-kappa_B activation by calcium/calmodulin-dependent _ protein_kinase_kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88 .
12052823	0	Akt	0,3	NF-kappa_B	30,40	Akt	NF-kappa B	11651(Tax:10090)	18033(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Akt is a downstream target of NF-kappa_B .
12649266	0	Akt	136,139	NF-kappa_B	113,123	Akt	NF-kappa B	207	4790	Gene	Gene	pathway|compound|START_ENTITY involves|nmod|pathway involves|dobj|activation activation|nmod|END_ENTITY	Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa_B through the Akt pathway .
12682234	0	Akt	159,162	NF-kappa_B	18,28	Akt	NF-kappa B	207	4790	Gene	Gene	activation|compound|START_ENTITY inhibiting|dobj|activation enhances|advcl|inhibiting enhances|nsubj|response response|amod|Expression Expression|nmod|X-ray-inducible X-ray-inducible|amod|END_ENTITY	Expression of the NF-kappa_B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation .
18931031	0	Akt	0,3	NOS3	14,18	Akt	NOS3	207	4846	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Akt activates NOS3 and separately restores barrier integrity in H2O2-stressed human cardiac microvascular endothelium .
18455424	0	Akt	43,46	NQO1	24,28	Akt	NQO1	24185(Tax:10116)	24314(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|dep|signaling	Bromocriptine activates NQO1 via Nrf2-PI3K / Akt signaling : novel cytoprotective mechanism against oxidative damage .
20661723	0	Akt	30,33	Nanog	77,82	Akt	Nanog	11651(Tax:10090)	71950(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	The phosphoinositide-3-kinase / Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells .
14985363	0	Akt	0,3	Ndrg2	51,56	Akt	Ndrg2	24185(Tax:10116)	171114(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Akt mediates insulin-stimulated phosphorylation of Ndrg2 : evidence for cross-talk with protein_kinase_C theta .
17715136	0	Akt	0,3	Nedd4-2	79,86	Akt	Nedd4-2	24185(Tax:10116)	291553(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2 .
17213958	0	Akt	144,147	Nerve_growth_factor	0,19	Akt	Nerve growth factor	24185(Tax:10116)	310738(Tax:10116)	Gene	Gene	activating|dobj|START_ENTITY prevents|advcl|activating prevents|nsubj|END_ENTITY	Nerve_growth_factor prevents the apoptosis-associated increase in acetylcholinesterase activity after hydrogen_peroxide treatment by activating Akt .
20651836	0	Akt	41,44	Neuregulin-1	0,12	Akt	Neuregulin-1	24185(Tax:10116)	112400(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Neuregulin-1 regulates the expression of Akt , Bcl-2 , and Bad signaling after focal cerebral_ischemia in rats .
15156571	0	Akt	33,36	Neurotensin	0,11	Akt	Neurotensin	207	4922	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Neurotensin negatively modulates Akt activity in neurotensin_receptor-1-transfected AV12 cells .
26850133	0	Akt	8,11	Notch1	26,32	Akt	Notch1	207	4851	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Role of Akt inhibition on Notch1 expression in hepatocellular_carcinoma : potential role for dual targeted therapy .
11274386	0	Akt	0,3	Nur77	61,66	Akt	Nur77	11651(Tax:10090)	15370(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt phosphorylates and regulates the orphan nuclear receptor Nur77 .
11438550	0	Akt	0,3	Nur77	41,46	Akt	Nur77	207	3164	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis .
23156673	0	Akt	83,86	P19	54,57	Akt	P19	11651(Tax:10090)	83430(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	N-acetylcysteine enhances neuronal differentiation of P19 embryonic stem cells via Akt and N-cadherin activation .
26946194	0	Akt	17,20	P2X4R	64,69	Akt	P2X4R	207	5025	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Expression Expression|compound|END_ENTITY	Relative Role of Akt , ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression .
23554696	0	Akt	24,27	PAK1	76,80	Akt	PAK1	207	5058	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Activation of Rac1-PI3K / Akt is required for epidermal_growth_factor-induced PAK1 activation and cell migration in MDA-MB-231 breast_cancer cells .
11278269	0	Akt	20,23	PDK1	74,78	Akt	PDK1	207	5163	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|advcl|blocking blocking|dobj|localization localization|nmod|END_ENTITY	Cyclic_AMP inhibits Akt activity by blocking the membrane localization of PDK1 .
11752451	0	Akt	30,33	PDK1	0,4	Akt	PDK1	41957(Tax:7227)	38017(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PDK1 regulates growth through Akt and S6K in Drosophila .
18347057	0	Akt	57,60	PDK1	16,20	Akt	PDK1	11651(Tax:10090)	228026(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|Mutation Mutation|nmod|domain domain|compound|END_ENTITY	Mutation of the PDK1 PH domain inhibits protein_kinase_B / Akt , leading to small size and insulin resistance .
19065678	0	Akt	111,114	PDK1	105,109	Akt	PDK1	11651(Tax:10090)	228026(Tax:10090)	Gene	Gene	modulate|nsubj|START_ENTITY phosphoinositide-dependent_protein_kinase_1|dep|modulate phosphoinositide-dependent_protein_kinase_1|dep|END_ENTITY	The survival pathways phosphatidylinositol-3_kinase -LRB- PI3-K -RRB- / phosphoinositide-dependent_protein_kinase_1 -LRB- PDK1 -RRB- / Akt modulate liver_regeneration through hepatocyte size rather than proliferation .
21906027	0	Akt	104,107	PDK1	80,84	Akt	PDK1	11651(Tax:10090)	228026(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	S6K inhibition renders cardiac protection against myocardial_infarction through PDK1 phosphorylation of Akt .
22177954	0	Akt	39,42	PDK1	70,74	Akt	PDK1	207	5163	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|advcl|affecting affecting|dobj|kinase kinase|compound|END_ENTITY	Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells .
22837796	0	Akt	95,98	PDK1	8,12	Akt	PDK1	24185(Tax:10116)	116551(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY activating|dobj|signaling apoptosis|advcl|activating kinase|ccomp|apoptosis kinase|nsubj|END_ENTITY	Induced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion .
23030823	0	Akt	0,3	PDK1	110,114	Akt	PDK1	207	5163	Gene	Gene	mechanisms|nsubj|START_ENTITY mechanisms|acl|leading leading|nmod|inhibitors inhibitors|nummod|END_ENTITY	Akt is efficiently activated by PIF-pocket - and PtdIns -LRB- 3,4,5 -RRB- P3-dependent mechanisms leading to resistance to PDK1 inhibitors .
24352480	0	Akt	44,47	PDK1	0,4	Akt	PDK1	207	5163	Gene	Gene	phosphorylates|nmod|START_ENTITY phosphorylates|nsubj|END_ENTITY	PDK1 selectively phosphorylates Thr -LRB- 308 -RRB- on Akt and contributes to human platelet functional responses .
26553931	0	Akt	85,88	PDK1	35,39	Akt	PDK1	11651(Tax:10090)	228026(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY survival|nmod|activation controls|dobj|survival controls|nsubj|AMIGO2 AMIGO2|appos|anchor anchor|nmod|END_ENTITY	AMIGO2 , a novel membrane anchor of PDK1 , controls cell survival and angiogenesis via Akt activation .
16118242	0	Akt	58,61	PECAM-1	8,15	Akt	PECAM-1	207	5175	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in endothelial cells .
16203862	0	Akt	48,51	PGC-1alpha	0,10	Akt	PGC-1alpha	207	10891	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|expression expression|amod|END_ENTITY	PGC-1alpha gene expression is down-regulated by Akt - mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle .
19203586	0	Akt	62,65	PHLDA3	23,29	Akt	PHLDA3	207	23612	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt .
20576936	0	Akt	29,32	PHLPP-1	0,7	Akt	PHLPP-1	11651(Tax:10090)	98432(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PHLPP-1 negatively regulates Akt activity and survival in the heart .
15389633	0	Akt	6,9	PI-3K	0,5	Akt	PI-3K	207	5293	Gene	Gene	pathways|compound|START_ENTITY activated|nsubjpass|pathways END_ENTITY|appos|activated	PI-3K / Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment .
15550174	0	Akt	91,94	PI-3K	85,90	Akt	PI-3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K / Akt cell survival pathway .
16000874	0	Akt	50,53	PI-3K	44,49	Akt	PI-3K	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	COX-2 inhibits anoikis by activation of the PI-3K / Akt pathway in human bladder_cancer cells .
16397275	9	Akt	1663,1666	PI-3K	1657,1662	Akt	PI-3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	It is likely that the inhibitory effects of fractions RO-FOO3 and RO-ME on B -LRB- a -RRB- PDE-induced AP-1 activation and VEGF expression are mediated by inhibition of the PI-3K / Akt pathway .
17370311	0	Akt	6,9	PI-3K	0,5	Akt	PI-3K	207	5293	Gene	Gene	signal|compound|START_ENTITY plays|nsubj|signal END_ENTITY|appos|plays	PI-3K / Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin_D1 .
17586659	0	Akt	143,146	PI-3K	137,142	Akt	PI-3K	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage : up-regulation of the PI-3K / Akt pathway .
18197291	0	Akt	6,9	PI-3K	0,5	Akt	PI-3K	207	5293	Gene	Gene	expression|amod|START_ENTITY responsible|nsubj|expression END_ENTITY|appos|responsible	PI-3K / Akt pathway-dependent cyclin_D1 expression is responsible for arsenite-induced human keratinocyte transformation .
18410948	0	Akt	102,105	PI-3K	96,101	Akt	PI-3K	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	inhibiting|nsubj|START_ENTITY neuroprotection|parataxis|inhibiting neuroprotection|nmod|cerebral_ischemic_injury cerebral_ischemic_injury|nmod|END_ENTITY	Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral_ischemic_injury via PI-3K / Akt pathway inhibiting the ASK1-JNK cascade .
18423117	0	Akt	26,29	PI-3K	20,25	Akt	PI-3K	207	5293	Gene	Gene	effect|parataxis|START_ENTITY effect|nmod|END_ENTITY	-LSB- Reversal effect of PI-3K / Akt pathway inhibitor LY294002 on multidrug resistance of ovarian_cancer cell line A2780/Taxol -RSB- .
18769058	0	Akt	70,73	PI-3K	64,69	Akt	PI-3K	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Hemangiopoietin promotes endothelial cell proliferation through PI-3K / Akt pathway .
19887077	0	Akt	144,147	PI-3K	138,143	Akt	PI-3K	24185(Tax:10116)	85243(Tax:10116)	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Brain-derived_neurotrophic_factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K / Akt pathways .
22928837	0	Akt	83,86	PI-3K	77,82	Akt	PI-3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	START_ENTITY|dep|inhibits inhibits|dobj|production production|nmod|END_ENTITY	Pistacia chinensis inhibits NO production and upregulates HO-1 induction via PI-3K / Akt pathway in LPS stimulated macrophage cells .
23377702	0	Akt	16,19	PI3	9,12	Akt	PI3	24185(Tax:10116)	408230(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Impaired PI3 K Akt expression in liver and skeletal muscle of ovariectomized rats .
11788651	0	Akt	86,89	PI3K	56,60	Akt	PI3K	207	5295	Gene	Gene	phosphorylation|amod|START_ENTITY activation|nmod|phosphorylation activation|compound|END_ENTITY	Fatty_acid-induced insulin resistance : decreased muscle PI3K activation but unchanged Akt phosphorylation .
11842081	0	Akt	41,44	PI3K	35,39	Akt	PI3K	207	5293	Gene	Gene	Bax|compound|START_ENTITY 3-kinase|dep|Bax 3-kinase|appos|END_ENTITY	The phosphatidylinositol 3-kinase -LRB- PI3K -RRB- - Akt pathway suppresses Bax translocation to mitochondria .
12875651	0	Akt	41,44	PI3K	35,39	Akt	PI3K	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	phosphatidylinositol-3_kinase|dep|START_ENTITY phosphatidylinositol-3_kinase|appos|END_ENTITY	The phosphatidylinositol-3_kinase -LRB- PI3K -RRB- - Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells .
13679867	0	Akt	70,73	PI3K	46,50	Akt	PI3K	207	5293	Gene	Gene	pathway|compound|START_ENTITY myelomas|nmod|pathway myelomas|nmod|inhibitors inhibitors|nummod|END_ENTITY	Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway .
16007268	0	Akt	48,51	PI3K	0,4	Akt	PI3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY effects|nmod|activation rescues|dobj|effects rescues|nsubj|END_ENTITY	PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury .
16380230	0	Akt	113,116	PI3K	56,60	Akt	PI3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY pathway|acl:relcl|mediated pathway|amod|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces c-myc expression through a PI3K - and MAPK-dependent pathway that is not mediated by Akt , PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes .
16741926	0	Akt	51,54	PI3K	45,49	Akt	PI3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Regulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt and nuclear_factor-kappa_B signaling pathways in dystrophin-deficient_skeletal_muscle in response to mechanical stretch .
17170431	0	Akt	81,84	PI3K	139,143	Akt	PI3K	207	5295	Gene	Gene	pathway|compound|START_ENTITY activates|dobj|pathway activates|nmod|subunit subunit|nmod|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
17170431	0	Akt	81,84	PI3K	75,79	Akt	PI3K	207	5295	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|dep|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
17468516	0	Akt	105,108	PI3K	100,104	Akt	PI3K	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Parathyroid_hormone-related_protein induces cell survival in human renal_cell_carcinoma through the PI3K Akt pathway : evidence for a critical role for integrin-linked_kinase and nuclear_factor_kappa_B .
18725974	0	Akt	88,91	PI3K	24,28	Akt	PI3K	207	5293	Gene	Gene	signaling|compound|START_ENTITY addicted|nmod|signaling addicted|nsubjpass|cells cells|nmod|mutation mutation|compound|END_ENTITY	Breast_tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling .
19009553	0	Akt	48,51	PI3K	42,46	Akt	PI3K	207	5295	Gene	Gene	c-Fos/c-Jun|dep|START_ENTITY c-Fos/c-Jun|compound|END_ENTITY	Ultrasound increased BMP-2 expression via PI3K , Akt , c-Fos/c-Jun , and AP-1 pathways in cultured osteoblasts .
19062713	0	Akt	17,20	PI3K	11,15	Akt	PI3K	207	5293	Gene	Gene	Impact|dep|START_ENTITY Impact|nmod|END_ENTITY	-LSB- Impact of PI3K / Akt / mdm2 signaling pathway on the sensitivity of gastric_cancer cell line SGC7901 to doxorubicin -RSB- .
19661335	0	Akt	149,152	PI3K	143,147	Akt	PI3K	207	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|appos|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
19835871	0	Akt	130,133	PI3K	124,128	Akt	PI3K	207	5293	Gene	Gene	3-kinase|dep|START_ENTITY 3-kinase|appos|END_ENTITY	BMP2 accelerates the motility and invasiveness of gastric_cancer cells via activation of the phosphatidylinositol 3-kinase -LRB- PI3K -RRB- / Akt pathway .
23665174	0	Akt	81,84	PI3K	0,4	Akt	PI3K	207	5293	Gene	Gene	epithelia|nmod|START_ENTITY initiation|nmod|epithelia regulates|dobj|initiation regulates|nsubj|END_ENTITY	PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively .
23687303	0	Akt	46,49	PI3K	40,44	Akt	PI3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY has|nsubj|signaling Enhanced|parataxis|has Enhanced|dep|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|appos|END_ENTITY	Enhanced phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress .
24338479	0	Akt	61,64	PI3K	55,59	Akt	PI3K	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling Manipulation|parataxis|regulates Manipulation|nmod|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|appos|END_ENTITY	Manipulation of cardiac phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling by apoptosis_regulator_through_modulating_IAP_expression -LRB- ARIA -RRB- regulates cardiomyocyte_death during doxorubicin-induced cardiomyopathy .
26115885	0	Akt	143,146	PI3K	119,123	Akt	PI3K	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	B|appos|START_ENTITY B|compound|/ /|appos|END_ENTITY	Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / protein kinase B -LRB- Akt -RRB- signaling pathway .
26148798	0	Akt	111,114	PI3K	105,109	Akt	PI3K	207	5293	Gene	Gene	START_ENTITY|nsubj|phosphatase phosphatase|dep|phosphoinositide phosphoinositide|dobj|3-kinase 3-kinase|appos|END_ENTITY	Small RNA profiling reveals deregulated phosphatase and tensin homolog -LRB- PTEN -RRB- / phosphoinositide 3-kinase -LRB- PI3K -RRB- / Akt pathway in bronchial smooth muscle cells from asthmatic patients .
26831566	0	Akt	55,58	PI3K	49,53	Akt	PI3K	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	Phosphatidylinositol_3_kinase|dep|START_ENTITY Phosphatidylinositol_3_kinase|appos|END_ENTITY	Icaritin requires Phosphatidylinositol_3_kinase -LRB- PI3K -RRB- / Akt signaling to counteract skeletal muscle_atrophy following mechanical unloading .
18512147	0	Akt	108,111	PI3_K	102,107	Akt	PI3 K	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Enhanced survival of melanopsin-expressing retinal ganglion cells after injury is associated with the PI3_K / Akt pathway .
25621554	0	Akt	124,127	PI3_Kinase	113,123	Akt	PI3 Kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Different Concentrations of Glucose Regulate Proliferation and Osteogenic Differentiation of Osteoblasts Via the PI3_Kinase / Akt Pathway .
20203419	0	Akt	150,153	PI3_kinase	139,149	Akt	PI3 kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	4-Methylcatechol-induced heme_oxygenase-1 exerts a protective effect against oxidative stress in cultured neural stem/progenitor cells via PI3_kinase / Akt pathway .
21109949	0	Akt	22,25	PI3_kinase	0,10	Akt	PI3 kinase	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY integrates|xcomp|signaling integrates|nsubj|END_ENTITY	PI3_kinase integrates Akt and MAP kinase signaling pathways in the regulation of prostate_cancer .
24634221	0	Akt	51,54	PI3k	45,49	Akt	PI3k	207	5295	Gene	Gene	signaling|compound|START_ENTITY 3-kinase|dep|signaling 3-kinase|appos|END_ENTITY	Role of c-Met/phosphatidylinositol _ 3-kinase -LRB- PI3k -RRB- / Akt signaling in hepatocyte_growth_factor -LRB- HGF -RRB- - mediated lamellipodia formation , reactive oxygen species -LRB- ROS -RRB- generation , and motility of lung endothelial cells .
11593385	0	Akt	121,124	PI_3-K	114,120	Akt	PI 3-K	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The anti-apoptotic role of interleukin-6 in human cervical_cancer is mediated by up-regulation of Mcl-1 through a PI_3-K / Akt pathway .
14755253	0	Akt	65,68	PI_3-K	58,64	Akt	PI 3-K	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Inositol_pentakisphosphate promotes apoptosis through the PI_3-K / Akt pathway .
23563366	0	Akt	62,65	PI_3-K	54,60	Akt	PI 3-K	207	5293	Gene	Gene	mTOR|appos|START_ENTITY mTOR|compound|END_ENTITY	Therapeutic targets for cancer : current concepts with PI_3-K , Akt , _ mTOR .
11751586	0	Akt	34,37	PRL	18,21	Akt	PRL	24185(Tax:10116)	24683(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the PRL promoter by Akt through cAMP response element binding protein .
27050145	0	Akt	47,50	PRSS8	17,22	Akt	PRSS8	11651(Tax:10090)	76560(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3 / Akt signaling in colorectal_cancer .
11071655	0	Akt	40,43	PTEN	8,12	Akt	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY leading|nmod|activation Loss|acl|leading Loss|nmod|expression expression|compound|END_ENTITY	Loss of PTEN expression leading to high Akt activation in human multiple_myelomas .
11162641	0	Akt	82,85	PTEN	89,93	Akt	PTEN	207	5728	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells .
11368352	0	Akt	13,16	PTEN	157,161	Akt	PTEN	24185(Tax:10116)	50557(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY Induction|nmod|phosphorylation occurs|nsubj|Induction occurs|dobj|evidence evidence|nmod|inhibition inhibition|nmod|END_ENTITY	Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol_3-kinase : no evidence for oxidative inhibition of PTEN .
11395387	0	Akt	70,73	PTEN	17,21	Akt	PTEN	207	5728	Gene	Gene	levels|compound|START_ENTITY linked|nmod|levels linked|nsubj|loss loss|nmod|expression expression|compound|END_ENTITY	Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels , but not associated with p27 and cyclin_D1 expression , in primary_epithelial_ovarian_carcinomas .
12622404	0	Akt	15,18	PTEN	0,4	Akt	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis .
12790783	0	Akt	36,39	PTEN	8,12	Akt	PTEN	207	5728	Gene	Gene	phosphorylation|compound|START_ENTITY followed|nmod|phosphorylation expression|acl|followed expression|compound|END_ENTITY	Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial_cancer .
12923562	0	Akt	109,112	PTEN	50,54	Akt	PTEN	207	5728	Gene	Gene	phosphorylated|dobj|START_ENTITY phosphorylated|nmod|therapy therapy|nmod|bladder_cancer bladder_cancer|nmod|growth growth|compound|END_ENTITY	In vivo gene therapy of human bladder_cancer with PTEN suppresses tumor growth , downregulates phosphorylated Akt , and increases sensitivity to doxorubicin .
14566704	0	Akt	80,83	PTEN	25,29	Akt	PTEN	207	5728	Gene	Gene	cause|nsubj|START_ENTITY inactivation|parataxis|cause inactivation|nmod|END_ENTITY	Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase / Akt pathway cause human Lhermitte-Duclos_disease in adults .
14603261	0	Akt	32,35	PTEN	10,14	Akt	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY modulate|dobj|phosphorylation modulate|nsubj|Levels Levels|nmod|protein protein|compound|END_ENTITY	Levels of PTEN protein modulate Akt phosphorylation on serine 473 , but not on threonine 308 , in IGF-II-overexpressing rhabdomyosarcomas cells .
15482376	0	Akt	77,80	PTEN	118,122	Akt	PTEN	24185(Tax:10116)	50557(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY damages|nmod|activation prevents|dobj|damages prevents|nmod|phosphorylation phosphorylation|compound|END_ENTITY	17_Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats .
15851405	0	Akt	0,3	PTEN	68,72	Akt	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY activation|dep|contribution contribution|nmod|expression expression|compound|END_ENTITY	Akt activation in renal_cell_carcinoma : contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor .
15900596	0	Akt	0,3	PTEN	43,47	Akt	PTEN	207	5728	Gene	Gene	START_ENTITY|nmod|LOH LOH|nmod|END_ENTITY	Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric_cancer .
16169459	0	Akt	54,57	PTEN	40,44	Akt	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	gets|dobj|START_ENTITY gets|nsubj|END_ENTITY	A new mouse model of pancreatic_cancer : PTEN gets its Akt together .
16324768	0	Akt	15,18	PTEN	46,50	Akt	PTEN	207	5728	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|expression expression|compound|END_ENTITY	Phosphorylated Akt overexpression and loss of PTEN expression in non-small_cell_lung_cancer confers poor prognosis .
17006756	0	Akt	97,100	PTEN	49,53	Akt	PTEN	207	5728	Gene	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|Coexistence Coexistence|nmod|loss loss|nmod|heterozygosity heterozygosity|nmod|locus locus|compound|END_ENTITY	Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone_receptor expression in breast_carcinoma .
17013611	0	Akt	14,17	PTEN	33,37	Akt	PTEN	207	5728	Gene	Gene	Activation|nmod|START_ENTITY independent|nsubj|Activation independent|nmod|END_ENTITY	Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical_dysplasias .
17276010	0	Akt	37,40	PTEN	14,18	Akt	PTEN	207	5728	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of PTEN and activation of Akt by menadione .
17302912	0	Akt	76,79	PTEN	14,18	Akt	PTEN	24185(Tax:10116)	50557(Tax:10116)	Gene	Gene	neuroprotective|compound|START_ENTITY activates|dobj|neuroprotective activates|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase / Akt neuroprotective signaling pathway .
17369849	0	Akt	0,3	PTEN	87,91	Akt	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY occurs|nsubj|activation occurs|nmod|oxidation oxidation|nmod|suppressor suppressor|compound|END_ENTITY	Akt activation by arachidonic_acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor .
17681738	0	Akt	62,65	PTEN	35,39	Akt	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY Co-existence|nmod|activation Co-existence|nmod|protein protein|compound|END_ENTITY	Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal_cell_carcinoma .
18425369	0	Akt	98,101	PTEN	0,4	Akt	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY implications|nmod|activation majority|dep|implications downregulated|nmod|majority downregulated|nsubjpass|END_ENTITY	PTEN and p27Kip1 are not downregulated in the majority of renal_cell_carcinomas -- implications for Akt activation .
19160672	0	Akt	63,66	PTEN	15,19	Akt	PTEN	207	5728	Gene	Gene	phosphorylated|dobj|START_ENTITY phosphorylated|nsubj|Measurement Measurement|nmod|activity activity|compound|END_ENTITY	Measurement of PTEN activity in vivo by imaging phosphorylated Akt .
19318457	0	Akt	60,63	PTEN	175,179	Akt	PTEN	207	5728	Gene	Gene	pathway|compound|START_ENTITY factor-I|dep|pathway attenuates|dobj|factor-I attenuates|parataxis|kinase kinase|nmod|increase increase|nmod|END_ENTITY	Insulin attenuates the insulin-like growth factor-I -LRB- IGF-I -RRB- - Akt pathway , not IGF-I-extracellularly regulated kinase pathway , in luteinized granulosa cells with an increase in PTEN .
19543271	0	Akt	19,22	PTEN	88,92	Akt	PTEN	207	5728	Gene	Gene	targeting|nsubj|START_ENTITY targeting|dobj|END_ENTITY	TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN .
20854947	0	Akt	67,70	PTEN	110,114	Akt	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	transduction|compound|START_ENTITY transduction|nmod|suppression suppression|nmod|activity activity|compound|END_ENTITY	Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity .
20975834	0	Akt	50,53	PTEN	35,39	Akt	PTEN	207	5728	Gene	Gene	activates|xcomp|START_ENTITY activates|nsubj|Alkylation Alkylation|nmod|END_ENTITY	Alkylation of the tumor suppressor PTEN activates Akt and b-catenin signaling : a mechanism linking inflammation and oxidative stress with cancer .
21415306	0	Akt	113,116	PTEN	57,61	Akt	PTEN	207	5728	Gene	Gene	activation|compound|START_ENTITY inhibition|nmod|activation inhibition|nsubj|homolog homolog|appos|END_ENTITY	Phosphatase and tensin homolog deleted on chromosome 10 -LRB- PTEN -RRB- inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes .
22000581	0	Akt	56,59	PTEN	118,122	Akt	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY down-regulation|nmod|expression down-regulation|dep|roles roles|nmod|END_ENTITY	Zinc_deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis : essential roles of PTEN , PTP1B and TRB3 .
22488521	0	Akt	65,68	PTEN	15,19	Akt	PTEN	207	5728	Gene	Gene	activation|nmod|START_ENTITY stability|nmod|activation perturbs|dobj|stability perturbs|nsubj|Attenuation Attenuation|nmod|END_ENTITY	Attenuation of PTEN perturbs genomic stability via activation of Akt and down-regulation of Rad51 in human embryonic kidney cells .
22940494	0	Akt	27,30	PTEN	50,54	Akt	PTEN	207	5728	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|cells cells|compound|END_ENTITY	Redox control of cytosolic Akt phosphorylation in PTEN null cells .
24295494	0	Akt	77,80	PTEN	96,100	Akt	PTEN	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	independent|nsubj|START_ENTITY independent|nmod|status status|compound|END_ENTITY	miR-221 / 222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status .
25683168	0	Akt	111,114	PTEN	11,15	Akt	PTEN	207	5728	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway Effects|nmod|cells Effects|nmod|END_ENTITY	Effects of PTEN on the proliferation and apoptosis of colorectal_cancer cells via the phosphoinositol-3-kinase / Akt pathway .
25934712	0	Akt	102,105	PTEN	12,16	Akt	PTEN	207	5728	Gene	Gene	Activation|nmod|START_ENTITY Cancer|nmod|Activation Resistance|nmod|Cancer Contributes|nmod|Resistance Contributes|compound|END_ENTITY	Correction : PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR .
26000878	0	Akt	141,144	PTEN	116,120	Akt	PTEN	207	5728	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation .
26148798	0	Akt	111,114	PTEN	72,76	Akt	PTEN	207	5728	Gene	Gene	START_ENTITY|nsubj|phosphatase phosphatase|appos|END_ENTITY	Small RNA profiling reveals deregulated phosphatase and tensin homolog -LRB- PTEN -RRB- / phosphoinositide 3-kinase -LRB- PI3K -RRB- / Akt pathway in bronchial smooth muscle cells from asthmatic patients .
26173079	0	Akt	153,156	PTEN	128,132	Akt	PTEN	207	5728	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Correction : Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation .
26666444	0	Akt	136,139	PTEN	24,28	Akt	PTEN	24185(Tax:10116)	50557(Tax:10116)	Gene	Gene	Inhibition|parataxis|START_ENTITY Inhibition|nmod|Cardioprotection Cardioprotection|compound|END_ENTITY	Selective Inhibition of PTEN Preserves Ischemic Postconditioning Cardioprotection in STZ-induced Type1 Diabetic Rats : Role of the PI3K / Akt and JAK2 / STAT3 Pathways .
18650932	0	Akt	15,18	Par-4	0,5	Akt	Par-4	11651(Tax:10090)	114774(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis .
18769154	0	Akt	0,3	Par-4	94,99	Akt	Par-4	207	347745	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|action action|nmod|END_ENTITY	Akt regulation and lung_cancer : a novel role and mechanism of action for the tumor suppressor Par-4 .
17468516	0	Akt	105,108	Parathyroid_hormone-related_protein	0,35	Akt	Parathyroid hormone-related protein	207	5744	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Parathyroid_hormone-related_protein induces cell survival in human renal_cell_carcinoma through the PI3K Akt pathway : evidence for a critical role for integrin-linked_kinase and nuclear_factor_kappa_B .
15288510	0	Akt	30,33	Phosphatidylinositol-3_kinase	0,29	Akt	Phosphatidylinositol-3 kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	mediated|nsubj|START_ENTITY END_ENTITY|parataxis|mediated	Phosphatidylinositol-3_kinase / Akt and GSK-3 mediated cytoprotective effect of epigallocatechin_gallate on oxidative stress-injured neuronal-differentiated N18D3 cells .
14615607	0	Akt	60,63	Phosphatidylinositol_3-Kinase	102,131	Akt	Phosphatidylinositol 3-Kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	Activity|nmod|START_ENTITY Activity|nmod|Interference Interference|nmod|Pathway Pathway|compound|END_ENTITY	Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol_3-Kinase Signaling Pathway .
25989537	0	Akt	140,143	Phosphatidylinositol_3-Kinase	110,139	Akt	Phosphatidylinositol 3-Kinase	207	5293	Gene	Gene	Pathway|compound|START_ENTITY Leptin|parataxis|Pathway Leptin|nmod|END_ENTITY	Leptin and Neutrophil-Activating_Peptide_2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol_3-Kinase / Akt Pathway in Patients With Systemic Lupus Erythematosus .
26198194	0	Akt	80,83	Phosphatidylinositol_3-Kinase	0,29	Akt	Phosphatidylinositol 3-Kinase	207	5293	Gene	Gene	Influx|nmod|START_ENTITY Influx|compound|END_ENTITY	Phosphatidylinositol_3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals .
11859074	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	207	5290	Gene	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling END_ENTITY|parataxis|required	Phosphatidylinositol_3-kinase / Akt signaling is neither required for hypoxic stabilization of HIF-1_alpha nor sufficient for HIF-1-dependent target gene transcription .
12167664	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	207	5293	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Phosphatidylinositol_3-kinase / Akt pathway regulates tuberous_sclerosis_tumor suppressor complex by phosphorylation of tuberin .
12183424	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Phosphatidylinositol_3-kinase / Akt signaling in the response of vascular endothelium to ionizing radiation .
16309568	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Phosphatidylinositol_3-kinase / Akt pathway mediates heme_oxygenase-1 regulation by lipopolysaccharide .
16310342	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	207	5290	Gene	Gene	involved|nsubjpass|START_ENTITY END_ENTITY|parataxis|involved	Phosphatidylinositol_3-kinase / Akt pathway is involved in transforming_growth_factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells .
16514645	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	Phosphatidylinositol_3-kinase / Akt plays a role in sphingosine_1-phosphate-stimulated HSP27 induction in osteoblasts .
16817229	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	auto-regulates|nsubj|START_ENTITY END_ENTITY|parataxis|auto-regulates	Phosphatidylinositol_3-kinase / Akt auto-regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts .
17172275	0	Akt	45,48	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	207	5290	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Phosphatidylinositol_3-kinase / protein kinase Akt negatively regulates plasminogen_activator_inhibitor_type_1 expression in vascular endothelial cells .
18777595	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Phosphatidylinositol_3-kinase / Akt pathway regulates hepatic stellate cell apoptosis .
20088406	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	207	5294	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Phosphatidylinositol_3-kinase / Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells .
22967108	0	Akt	147,150	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY involve|dobj|activation regulator|acl:relcl|involve regulator|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase is an upstream regulator of the phosphodiesterase_3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus .
26192967	0	Akt	30,33	Phosphatidylinositol_3-kinase	0,29	Akt	Phosphatidylinositol 3-kinase	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Phosphatidylinositol_3-kinase / Akt signaling as a key mediator of tumor cell responsiveness to radiation .
19819979	0	Akt	30,33	Phosphatidylinositol_3_kinase	0,29	Akt	Phosphatidylinositol 3 kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signal|nsubj|START_ENTITY END_ENTITY|parataxis|signal	Phosphatidylinositol_3_kinase / Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony_stimulating_factor-1 -LRB- CSF-1 -RRB- expression and osteoclast differentiation .
16036919	0	Akt	39,42	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Phosphoinositide_3-kinase signaling to Akt promotes keratinocyte differentiation versus death .
16115127	0	Akt	26,29	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	207	5293	Gene	Gene	inhibition|compound|START_ENTITY increases|nsubj|inhibition END_ENTITY|parataxis|increases	Phosphoinositide_3-kinase / Akt inhibition increases arsenic_trioxide-induced apoptosis of acute promyelocytic and T-cell_leukaemias .
16642045	0	Akt	26,29	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Phosphoinositide_3-kinase / Akt signaling pathway and its therapeutical implications for human acute_myeloid_leukemia .
17935137	0	Akt	26,29	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	207	5295	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	Phosphoinositide_3-kinase / Akt pathway plays an important role in chemoresistance of gastric_cancer cells against etoposide and doxorubicin induced cell death .
19051078	0	Akt	26,29	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	207	5293	Gene	Gene	signalling|compound|START_ENTITY responsible|nsubj|signalling END_ENTITY|parataxis|responsible	Phosphoinositide_3-kinase / Akt signalling is responsible for the differential susceptibility of myoblasts and myotubes to menadione-induced oxidative stress .
21472268	0	Akt	26,29	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	207	5293	Gene	Gene	involved|nsubjpass|START_ENTITY END_ENTITY|parataxis|involved	Phosphoinositide_3-kinase / Akt and nuclear factor kB pathways are involved in tumor_necrosis_factor-related_apoptosis-inducing_ligand resistance in human gastric_cancer cells .
23206708	0	Akt	26,29	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY essential|nsubj|signaling END_ENTITY|parataxis|essential	Phosphoinositide_3-kinase / Akt signaling is essential for prostaglandin_E2-induced osteogenic differentiation of rat tendon stem cells .
23859135	0	Akt	26,29	Phosphoinositide_3-kinase	0,25	Akt	Phosphoinositide 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY END_ENTITY|parataxis|involved	Phosphoinositide_3-kinase / Akt pathway is involved in mediating the anti-inflammation effects of magnesium_sulfate .
25800443	0	Akt	123,126	Phosphoinositide_3-kinase	97,122	Akt	Phosphoinositide 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Inflammation|dep|Pathway Inflammation|nmod|END_ENTITY	Maternal Disononyl_Phthalate Exposure Activates Allergic Airway Inflammation via Stimulating the Phosphoinositide_3-kinase / Akt Pathway in Rat Pups .
26208383	0	Akt	83,86	Platelet-Derived_Growth_Factor_Receptor-b	144,185	Akt	Platelet-Derived Growth Factor Receptor-b	207	5159	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate_Receptor_3 / Platelet-Derived_Growth_Factor_Receptor-b .
26648031	0	Akt	59,62	PlexinD1	67,75	Akt	PlexinD1	207	23129	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Semaphorin_4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor .
16452497	0	Akt	87,90	Polycystin-1	0,12	Akt	Polycystin-1	207	5310	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol_3-kinase / Akt signaling pathway .
21841774	0	Akt	60,63	Presenilin_1	0,12	Akt	Presenilin 1	11651(Tax:10090)	19164(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|nsubj|END_ENTITY	Presenilin_1 regulates homeostatic synaptic scaling through Akt signaling .
25719244	0	Akt	0,3	Prohibitin_1	19,31	Akt	Prohibitin 1	207	5245	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt phosphorylates Prohibitin_1 to mediate its mitochondrial localization and promote proliferation of bladder_cancer cells .
20936097	0	Akt	64,67	Protein_Kinase_B	47,63	Akt	Protein Kinase B	207	2185	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Cholesteryl_Glucoside_Stimulates Activation of Protein_Kinase_B / Akt in the Motor Neuron-Derived NSC34 Cell Line .
10330141	0	Akt	17,20	Protein_kinase_B	0,16	Akt	Protein kinase B	207	2185	Gene	Gene	participates|nsubj|START_ENTITY END_ENTITY|parataxis|participates	Protein_kinase_B / Akt participates in GLUT4 translocation by insulin in L6 myoblasts .
12393870	0	Akt	17,20	Protein_kinase_B	0,16	Akt	Protein kinase B	207	2185	Gene	Gene	prevents|nsubj|START_ENTITY END_ENTITY|parataxis|prevents	Protein_kinase_B / Akt prevents fatty_acid-induced apoptosis in pancreatic beta-cells -LRB- INS-1 -RRB- .
15047842	0	Akt	17,20	Protein_kinase_B	0,16	Akt	Protein kinase B	207	2185	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Protein_kinase_B / Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent .
16243840	0	Akt	17,20	Protein_kinase_B	0,16	Akt	Protein kinase B	207	2185	Gene	Gene	kinase|nsubj|START_ENTITY END_ENTITY|parataxis|kinase	Protein_kinase_B / Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size .
16940564	0	Akt	17,20	Protein_kinase_B	0,16	Akt	Protein kinase B	207	2185	Gene	Gene	modulates|nsubj|START_ENTITY END_ENTITY|parataxis|modulates	Protein_kinase_B / Akt modulates nephrotoxicant-induced necrosis in renal cells .
23642408	0	Akt	17,20	Protein_kinase_B	0,16	Akt	Protein kinase B	207	2185	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	Protein_kinase_B / Akt is required for complete Freund 's adjuvant-induced upregulation of Nav1 .7 and Nav1 .8 in primary sensory neurons .
9484781	0	Akt	17,20	Protein_kinase_B	0,16	Akt	Protein kinase B	207	2185	Gene	Gene	activated|nsubjpass|START_ENTITY END_ENTITY|parataxis|activated	Protein_kinase_B / Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism .
11326545	0	Akt	17,20	Proteinkinase_B	1,16	Akt	Proteinkinase B	207	2185	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|dep|-RSB-	-LSB- Proteinkinase_B / Akt -RSB- .
22759636	0	Akt	82,85	Pten	104,108	Akt	Pten	41957(Tax:7227)	43991(Tax:7227)	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam .
25531328	0	Akt	22,25	Pten	74,78	Akt	Pten	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|model model|compound|END_ENTITY	Loss of ATF3 promotes Akt activation and prostate_cancer development in a Pten knockout mouse model .
26023714	0	Akt	69,72	Pten	37,41	Akt	Pten	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	Inactivation|compound|START_ENTITY Mice|nmod|Inactivation KO|dobj|Mice KO|nsubj|Steatosis Steatosis|nmod|Specific Specific|compound|END_ENTITY	1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation .
26023714	0	Akt	69,72	Pten	37,41	Akt	Pten	11651(Tax:10090)	19211(Tax:10090)	Gene	Gene	Inactivation|compound|START_ENTITY Mice|nmod|Inactivation KO|dobj|Mice KO|nsubj|Steatosis Steatosis|nmod|Specific Specific|compound|END_ENTITY	1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation .
10803462	0	Akt	56,59	R-Ras3	0,6	Akt	R-Ras3	24185(Tax:10116)	22808	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	R-Ras3 , a brain-specific Ras-related protein , activates Akt and promotes cell survival in PC12 cells .
23469174	0	Akt	0,3	RIP1	43,47	Akt	RIP1	11651(Tax:10090)	19766(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis .
10576742	0	Akt	41,44	Raf	34,37	Akt	Raf	207	22882	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and regulation of Raf by Akt -LRB- protein kinase B -RRB- .
14707121	0	Akt	39,42	Ras_GTPase-activating_protein	0,29	Akt	Ras GTPase-activating protein	207	5921	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Ras_GTPase-activating_protein binds to Akt and is required for its activation .
11707464	0	Akt	0,3	SEK1	44,48	Akt	SEK1	207	6416	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Akt -LRB- protein kinase B -RRB- negatively regulates SEK1 by means of protein phosphorylation .
23440515	0	Akt	15,18	SGT1	0,4	Akt	SGT1	207	10910	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric_cancer cells .
22990594	0	Akt	97,100	SIRT1	0,5	Akt	SIRT1	207	23411	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway inhibits|nmod|activation inhibits|nsubj|END_ENTITY	SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway .
25986942	0	Akt	70,73	SOX2	85,89	Akt	SOX2	24185(Tax:10116)	499593(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	In oesophageal squamous cells , nitric_oxide causes S-nitrosylation of Akt and blocks SOX2 -LRB- sex_determining_region_Y-box_2 -RRB- expression .
19433130	0	Akt	99,102	SRC-3	73,78	Akt	SRC-3	207	8202	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Gambogic_acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells .
22005015	0	Akt	0,3	SREBP-2	63,70	Akt	SREBP-2	207	6721	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Akt acutely activates the cholesterogenic transcription factor SREBP-2 .
21723501	0	Akt	0,3	SREBP1c	23,30	Akt	SREBP1c	11651(Tax:10090)	20787(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways .
25576887	0	Akt	66,69	SUR2A	48,53	Akt	SUR2A	11651(Tax:10090)	20928(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Mild hypoxia in vivo regulates cardioprotective SUR2A : A role for Akt and LDH .
26648031	0	Akt	59,62	Semaphorin_4A	0,13	Akt	Semaphorin 4A	207	64218	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Semaphorin_4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor .
15358188	0	Akt	39,42	Senescence_marker_protein-30	0,28	Akt	Senescence marker protein-30	207	9104	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Senescence_marker_protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells .
18788627	0	Akt	45,48	Smac	29,33	Akt	Smac	207	56616	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	-LSB- Inhibition of mitochondrial Smac release by Akt in chemoresistant ovarian_cancer cells -RSB- .
15104092	0	Akt	0,3	Smad3	28,33	Akt	Smad3	207	4088	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis .
26208383	0	Akt	83,86	Sphingosine-1-Phosphate_Receptor_3	109,143	Akt	Sphingosine-1-Phosphate Receptor 3	207	1903	Gene	Gene	Pathway|compound|START_ENTITY Pathway|nmod|END_ENTITY	Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate_Receptor_3 / Platelet-Derived_Growth_Factor_Receptor-b .
15632208	0	Akt	104,107	Sphingosine_kinase-1	0,20	Akt	Sphingosine kinase-1	207	8877	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Sphingosine_kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K / Akt and regulation of Bcl-2 family members .
12600984	0	Akt	83,86	Src	20,23	Akt	Src	207	6714	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|Interaction Interaction|nmod|END_ENTITY	Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation .
16669788	0	Akt	78,81	Src	24,27	Akt	Src	24185(Tax:10116)	83805(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells regulates|dobj|apoptosis regulates|nsubj|activation activation|compound|END_ENTITY	Integrin_beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3 .
25338626	0	Akt	94,97	Src	53,56	Akt	Src	11651(Tax:10090)	20779(Tax:10090)	Gene	Gene	bortezomib|compound|START_ENTITY epidermal_growth_factor_receptor|dep|bortezomib species|dep|epidermal_growth_factor_receptor species|dep|activation activation|nmod|END_ENTITY	Reactive oxygen species - mediated activation of the Src - epidermal_growth_factor_receptor - Akt signaling cascade prevents bortezomib - induced apoptosis in hepatocellular_carcinoma cells .
25725285	0	Akt	55,58	Src	31,34	Akt	Src	207	6714	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABABR-mediated chemotaxis .
20849614	0	Akt	0,3	Stat5	20,25	Akt	Stat5	11651(Tax:10090)	20850(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	Akt is required for Stat5 activation and mammary differentiation .
22975683	0	Akt	40,43	Syndecan_4	0,10	Akt	Syndecan 4	207	6385	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Syndecan_4 regulation of PDK1-dependent Akt activation .
18161870	0	Akt	81,84	TGF-beta1	20,29	Akt	TGF-beta1	207	7040	Gene	Gene	enhance|nmod|START_ENTITY enhance|nsubj|END_ENTITY	Osteoblasts-derived TGF-beta1 enhance motility and integrin upregulation through Akt , ERK , and NF-kappaB-dependent pathway in human breast_cancer cells .
14732356	0	Akt	35,38	THP-1	87,92	Akt	THP-1	207	2736	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Simvastatin suppresses LPS-induced Akt phosphorylation in the human monocyte cell line THP-1 .
16107690	0	Akt	30,33	TIMP-1	126,132	Akt	TIMP-1	11651(Tax:10090)	21857(Tax:10090)	Gene	Gene	renders|nsubj|START_ENTITY renders|xcomp|competent competent|nmod|transactivation transactivation|compound|END_ENTITY	Phosphatidylinositol_3-kinase / Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation .
22957045	0	Akt	71,74	TIMP-1	49,55	Akt	TIMP-1	207	7076	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Nitric_oxide synthase and breast_cancer : role of TIMP-1 in NO-mediated Akt activation .
11705740	0	Akt	0,3	TNF-alpha	36,45	Akt	TNF-alpha	11651(Tax:10090)	21926(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Akt protects mouse hepatocytes from TNF-alpha - and Fas-mediated apoptosis through NK-kappa B activation .
18557926	0	Akt	21,24	TNF-alpha	0,9	Akt	TNF-alpha	207	7124	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes .
23469174	0	Akt	0,3	TNFa	14,18	Akt	TNFa	11651(Tax:10090)	21926(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|compound|END_ENTITY	Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis .
15792609	0	Akt	39,42	TNFalpha	0,8	Akt	TNFalpha	207	7124	Gene	Gene	signals|compound|START_ENTITY induction|nmod|signals played|nmod|induction played|nsubj|END_ENTITY	TNFalpha played a role in induction of Akt and MAPK signals in ameloblastoma .
16140562	0	Akt	14,17	TNFalpha	58,66	Akt	TNFalpha	207	7124	Gene	Gene	pathways|compound|START_ENTITY Inhibition|nmod|pathways elevated|nsubj|Inhibition elevated|dobj|potential potential|nmod|END_ENTITY	Inhibition of Akt and MAPK pathways elevated potential of TNFalpha in inducing apoptosis in ameloblastoma .
19836430	0	Akt	44,47	TNFalpha	0,8	Akt	TNFalpha	207	7124	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	TNFalpha induced oxidative stress dependent Akt signaling affects actin cytoskeletal organization in glioma cells .
24993240	0	Akt	68,71	TRAF4	0,5	Akt	TRAF4	207	9618	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	TRAF4 promotes tumorigenesis of breast_cancer through activation of Akt .
26418879	0	Akt	14,17	TTK	0,3	Akt	TTK	207	7272	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TTK activates Akt and promotes proliferation and migration_of_hepatocellular_carcinoma cells .
16157221	0	Akt	51,54	Tenascin-C	0,10	Akt	Tenascin-C	207	3371	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Tenascin-C promotes cell survival by activation of Akt in human chondrosarcoma cell .
27022065	0	Akt	36,39	Trop-2	0,6	Akt	Trop-2	207	4070	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Trop-2 induces tumor growth through Akt and determines sensitivity to Akt inhibitors .
19609361	0	Akt	0,3	Tsc1	24,28	Akt	Tsc1	41957(Tax:7227)	42862(Tax:7227)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt phosphorylates both Tsc1 and Tsc2 in Drosophila , but neither phosphorylation is required for normal animal growth .
12172554	0	Akt	0,3	Tsc2	49,53	Akt	Tsc2	41957(Tax:7227)	40201(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Akt regulates growth by directly phosphorylating Tsc2 .
15466161	0	Akt	33,36	Tsc2	0,4	Akt	Tsc2	41957(Tax:7227)	40201(Tax:7227)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Tsc2 is not a critical target of Akt during normal Drosophila development .
16027169	0	Akt	23,26	Tsc2	73,77	Akt	Tsc2	11651(Tax:10090)	22084(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY inhibition|nmod|signaling limits|nsubj|inhibition limits|dobj|growth growth|nmod|tumors tumors|acl|lacking lacking|dobj|END_ENTITY	Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2 .
24632604	0	Akt	76,79	Tsc2	19,23	Akt	Tsc2	11651(Tax:10090)	22084(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY show|dobj|inhibition show|nsubj|Renal_tumours Renal_tumours|nmod|model model|amod|END_ENTITY	Renal_tumours in a Tsc2 -LRB- + / - -RRB- mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin .
23946798	0	Akt	67,70	Twist2	0,6	Akt	Twist2	207	117581	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Twist2 promotes ovarian_cancer cell survival through activation of Akt .
21826248	0	Akt	20,23	VP1	12,15	Akt	VP1	11651(Tax:10090)	65130(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Recombinant VP1 , an Akt inhibitor , suppresses progression of hepatocellular_carcinoma by inducing apoptosis and modulation of CCL2 production .
25012178	0	Akt	65,68	Vascular_Endothelial_Growth_Factor	17,51	Akt	Vascular Endothelial Growth Factor	207	7422	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Signaling Signaling|compound|END_ENTITY	GIV/Girdin Links Vascular_Endothelial_Growth_Factor Signaling to Akt Survival Signaling in Podocytes Independent of Nephrin .
20189988	0	Akt	31,34	WDFY2	70,75	Akt	WDFY2	207	115825	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2 .
11280739	0	Akt	15,18	XIAP	0,4	Akt	XIAP	207	331	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian_epithelial_cancer cells .
14645242	0	Akt	0,3	XIAP	82,86	Akt	XIAP	207	331	Gene	Gene	START_ENTITY|dobj|phosphorylation phosphorylation|nmod|X-linked_inhibitor_of_apoptosis_protein X-linked_inhibitor_of_apoptosis_protein|appos|END_ENTITY	Akt phosphorylation and stabilization of X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- .
19649722	0	Akt	19,22	XIAP	45,49	Akt	XIAP	207	331	Gene	Gene	course|nmod|START_ENTITY activation|nsubj|course activation|nmod|expression expression|compound|END_ENTITY	The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line .
23613836	0	Akt	74,77	XIAP	60,64	Akt	XIAP	207	331	Gene	Gene	regulation|compound|START_ENTITY mediated|dobj|regulation mediated|nsubj|effects effects|nmod|thymoquinone thymoquinone|nmod|END_ENTITY	Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast_cancer .
15806160	0	Akt	0,3	Y-box_binding_protein_1	23,46	Akt	Y-box binding protein 1	207	4904	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt phosphorylates the Y-box_binding_protein_1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast_cancer cells .
12535517	0	Akt	0,3	Yes-associated_protein	23,45	Akt	Yes-associated protein	207	10413	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt phosphorylates the Yes-associated_protein , YAP , to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis .
23050488	0	Akt	78,81	adiponectin	9,20	Akt	adiponectin	207	9370	Gene	Gene	apoptosis|nmod|START_ENTITY signaling|nsubj|apoptosis protects|advcl|signaling protects|nsubj|END_ENTITY	Globular adiponectin protects H9c2 cells from palmitate-induced apoptosis via Akt and ERK1/2 signaling pathways .
12623995	0	Akt	16,19	angiotensin_II	47,61	Akt	angiotensin II	207	183	Gene	Gene	activation|compound|START_ENTITY inhibited|nsubjpass|activation inhibited|nmod|END_ENTITY	Insulin-induced Akt activation is inhibited by angiotensin_II in the vasculature through protein_kinase_C-alpha .
15849355	0	Akt	74,77	angiotensin_II	21,35	Akt	angiotensin II	24185(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Resveratrol inhibits angiotensin_II - and epidermal_growth_factor-mediated Akt activation : role of Gab1 and Shp2 .
21071431	0	Akt	19,22	angiotensin_II	37,51	Akt	angiotensin II	24185(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|cells cells|amod|END_ENTITY	Resveratrol blocks Akt activation in angiotensin_II - or EGF-stimulated vascular smooth muscle cells in a redox-independent manner .
21321983	0	Akt	15,18	angiotensin_II_type-1_receptor	32,62	Akt	angiotensin II type-1 receptor	24185(Tax:10116)	81638(Tax:10116)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Phosphorylated Akt up-regulates angiotensin_II_type-1_receptor expression in castration resistant prostate_cancer .
24338479	0	Akt	61,64	apoptosis_regulator_through_modulating_IAP_expression	78,131	Akt	apoptosis regulator through modulating IAP expression	11651(Tax:10090)	68545(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Manipulation of cardiac phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling by apoptosis_regulator_through_modulating_IAP_expression -LRB- ARIA -RRB- regulates cardiomyocyte_death during doxorubicin-induced cardiomyopathy .
23672191	0	Akt	209,212	b-catenin	136,145	Akt	b-catenin	207	1499	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	ARS-interacting_multi-functional_protein_1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of b-catenin via fibroblast_growth_factor_receptor_2-mediated activation of Akt .
25079689	0	Akt	71,74	b-catenin	28,37	Akt	b-catenin	207	1499	Gene	Gene	roles|nmod|START_ENTITY evidence|nmod|roles suppression|dep|evidence suppression|nmod|signaling signaling|amod|END_ENTITY	IFNy-induced suppression of b-catenin signaling : evidence for roles of Akt and 14.3.3 .
19239323	0	Akt	72,75	beta-arrestin2	0,14	Akt	beta-arrestin2	207	409	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	beta-arrestin2 inhibits opioid-induced breast_cancer cell death through Akt and caspase-8 pathways .
19850036	0	Akt	65,68	beta-catenin	20,32	Akt	beta-catenin	207	1499	Gene	Gene	activation|nmod|START_ENTITY signaling|nmod|activation END_ENTITY|acl|signaling	Osteopontin induces beta-catenin signaling through activation of Akt in prostate_cancer cells .
23092893	0	Akt	0,3	bmi1	49,53	Akt	bmi1	207	648	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus .
12584727	0	Akt	71,74	c-Jun_N-terminal_kinase	93,116	Akt	c-Jun N-terminal kinase	207	5599	Gene	Gene	START_ENTITY|appos|kinase kinase|compound|kinase kinase|amod|END_ENTITY	Pyrrolidine_dithiocarbamate-induced neuronal cell death is mediated by Akt , casein kinase 2 , c-Jun_N-terminal_kinase , and IkappaB kinase in embryonic hippocampal progenitor cells .
15890643	0	Akt	247,250	c-Jun_N-terminal_kinase	252,275	Akt	c-Jun N-terminal kinase	24185(Tax:10116)	116554(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
22583868	0	Akt	225,228	c-Jun_N-terminal_kinase-2	178,203	Akt	c-Jun N-terminal kinase-2	207	5601	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Protective effect of the poly -LRB- ADP-ribose -RRB- polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular_carcinoma cells involves attenuation of c-Jun_N-terminal_kinase-2 and protein_kinase_B / Akt activation .
15890643	0	Akt	247,250	c-Src	209,214	Akt	c-Src	24185(Tax:10116)	83805(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
19262695	0	Akt	16,19	c-Src	0,5	Akt	c-Src	207	6714	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and - dependent mechanisms .
10632601	0	Akt	117,120	caspase-3	155,164	Akt	caspase-3	24185(Tax:10116)	25402(Tax:10116)	Gene	Gene	death|nmod|START_ENTITY cells|nmod|death phosphorylation|nsubj|cells phosphorylation|advcl|END_ENTITY	Insulin-like_growth_factor-I protects axotomized rat retinal_ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo .
15024023	0	Akt	0,3	caspase-3	84,93	Akt	caspase-3	207	836	Gene	Gene	blocks|compound|START_ENTITY apoptosis|nsubj|blocks apoptosis|advcl|inhibiting inhibiting|xcomp|END_ENTITY	Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion .
16885155	0	Akt	96,99	caspase-3	57,66	Akt	caspase-3	207	836	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	ERK promotes hydrogen_peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells .
19513559	0	Akt	168,171	caspase-3	132,141	Akt	caspase-3	207	836	Gene	Gene	downregulation|nmod|START_ENTITY associated|nmod|downregulation associated|nmod|activation activation|nmod|END_ENTITY	Induction of apoptosis in human lung_carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt .
22764594	0	Akt	76,79	caspase-3	47,56	Akt	caspase-3	11651(Tax:10090)	12367(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	-LSB- Effect of electroacupuncture on expression of caspase-3 and phosphorylated Akt proteins in the skeleton muscle in diabetic mice -RSB- .
24038446	0	Akt	27,30	caspase-3	44,53	Akt	caspase-3	207	836	Gene	Gene	Smac|nmod|START_ENTITY Phosphorylation|nmod|Smac promotes|nsubj|Phosphorylation promotes|dobj|activation activation|amod|END_ENTITY	Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells .
12684678	0	Akt	29,32	caspase_3	9,18	Akt	caspase 3	207	836	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Inactive caspase_3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol_ester .
24574517	0	Akt	132,135	cyclin_B1	107,116	Akt	cyclin B1	207	891	Gene	Gene	phosphorylation|compound|START_ENTITY expression|nmod|phosphorylation expression|amod|END_ENTITY	Androgen_receptor promotes the oncogenic function of overexpressed Jagged1 in prostate_cancer by enhancing cyclin_B1 expression via Akt phosphorylation .
10910956	0	Akt	126,129	cyclin_D1	72,81	Akt	cyclin D1	24185(Tax:10116)	58919(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY associated|nmod|activation stabilization|acl|associated stabilization|amod|END_ENTITY	A potential mechanism for fumonisin_B -LRB- 1 -RRB- - mediated hepatocarcinogenesis : cyclin_D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity .
16443763	0	Akt	0,3	cyclin_D1	50,59	Akt	cyclin D1	11651(Tax:10090)	12443(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Akt induces beta-cell proliferation by regulating cyclin_D1 , cyclin_D2 , and p21 levels and cyclin-dependent_kinase-4 activity .
17370311	0	Akt	6,9	cyclin_D1	129,138	Akt	cyclin D1	207	595	Gene	Gene	signal|compound|START_ENTITY plays|nsubj|signal plays|nmod|induction induction|nmod|END_ENTITY	PI-3K / Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin_D1 .
17935714	0	Akt	105,108	cyclin_D1	77,86	Akt	cyclin D1	207	595	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Abrogation of p53 by its antisense in MCF-7 breast_carcinoma cells increases cyclin_D1 via activation of Akt and promotion of cell proliferation .
18197291	0	Akt	6,9	cyclin_D1	28,37	Akt	cyclin D1	207	595	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	PI-3K / Akt pathway-dependent cyclin_D1 expression is responsible for arsenite-induced human keratinocyte transformation .
18562319	0	Akt	119,122	cyclin_D1	53,62	Akt	cyclin D1	207	595	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|dobj|function function|amod|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_A1 regulates cyclin_D1 and c-myc internal ribosome entry site function through Akt signaling .
18769147	0	Akt	47,50	cyclin_D1	95,104	Akt	cyclin D1	207	595	Gene	Gene	crossroad|nmod|START_ENTITY activation|amod|crossroad activation|acl|enhance enhance|dobj|stability stability|amod|END_ENTITY	GSK-3beta inhibition : at the crossroad between Akt and mTOR constitutive activation to enhance cyclin_D1 protein stability in mantle_cell_lymphoma .
24044882	0	Akt	23,26	cyclin_D1	98,107	Akt	cyclin D1	207	595	Gene	Gene	targeting|nmod|START_ENTITY Molecular|acl|targeting promotes|nsubj|Molecular promotes|dep|arrest arrest|nmod|inhibition inhibition|nmod|END_ENTITY	Molecular targeting of Akt by thymoquinone promotes G -LRB- 1 -RRB- arrest through translation inhibition of cyclin_D1 and induces apoptosis in breast_cancer cells .
20600027	0	Akt	0,3	deleted_in_liver_cancer_1	23,48	Akt	deleted in liver cancer 1	11651(Tax:10090)	50768(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Akt phosphorylation of deleted_in_liver_cancer_1 abrogates its suppression of liver_cancer tumorigenesis and metastasis .
25139876	0	Akt	82,85	disco-interacting_protein_2_homolog_A	44,81	Akt	disco-interacting protein 2 homolog A	24185(Tax:10116)	690211(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Follistatin-like_1 attenuates apoptosis via disco-interacting_protein_2_homolog_A / Akt pathway after middle_cerebral_artery_occlusion in rats .
21777508	0	Akt	35,38	dopamine_D2_receptor	4,24	Akt	dopamine D2 receptor	207	1813	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The dopamine_D2_receptor regulates Akt and GSK-3 via Dvl-3 .
23188702	0	Akt	38,41	dopamine_D2_receptor	89,109	Akt	dopamine D2 receptor	11651(Tax:10090)	13489(Tax:10090)	Gene	Gene	START_ENTITY|acl|phosphorylation phosphorylation|nmod|hippocampus hippocampus|nmod|mice mice|amod|END_ENTITY	Kainic_acid-induced seizures modulate Akt -LRB- SER473 -RRB- phosphorylation in the hippocampus of dopamine_D2_receptor knockout mice .
17130842	0	Akt	17,20	eEF1A2	0,6	Akt	eEF1A2	207	1917	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling , invasion and migration .
18706892	0	Akt	34,37	eIF4E	18,23	Akt	eIF4E	207	1977	Gene	Gene	survival|compound|START_ENTITY survival|amod|END_ENTITY	Ribavirin targets eIF4E dependent Akt survival signaling .
12895435	0	Akt	118,121	endothelial_nitric_oxide_synthase	39,72	Akt	endothelial nitric oxide synthase	207	4846	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Insulin enhances the expression of the endothelial_nitric_oxide_synthase in native endothelial cells : a dual role for Akt and AP-1 .
18192589	0	Akt	81,84	endothelial_nitric_oxide_synthase	32,65	Akt	endothelial nitric oxide synthase	100294652(Tax:9940)	443077(Tax:9940)	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Protein kinase Cdelta regulates endothelial_nitric_oxide_synthase expression via Akt activation and nitric_oxide generation .
12472891	0	Akt	36,39	epidermal_growth_factor_receptor	48,80	Akt	epidermal growth factor receptor	11651(Tax:10090)	13649(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Nicotine-induced phosphorylation of Akt through epidermal_growth_factor_receptor and Src in PC12h cells .
16055672	0	Akt	57,60	epidermal_growth_factor_receptor	21,53	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	paths|nmod|START_ENTITY paths|nmod|END_ENTITY	Alternate paths from epidermal_growth_factor_receptor to Akt in malignant versus nontransformed lung epithelial cells : ErbB3 versus Gab1 .
16675591	0	Akt	87,90	epidermal_growth_factor_receptor	140,172	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	activation|compound|START_ENTITY dependent|nsubj|activation dependent|nmod|activation activation|compound|END_ENTITY	Gefitinib inhibits the growth and invasion of urothelial_carcinoma cell lines in which Akt and MAPK activation is dependent on constitutive epidermal_growth_factor_receptor activation .
16928826	0	Akt	16,19	epidermal_growth_factor_receptor	27,59	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	START_ENTITY|nmod|erlotinib erlotinib|compound|END_ENTITY	Inactivation of Akt by the epidermal_growth_factor_receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal_tumor cell lines and contributes to erlotinib sensitivity .
17349623	0	Akt	36,39	epidermal_growth_factor_receptor	52,84	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|pathway pathway|compound|END_ENTITY	Gastrin-releasing_peptide activates Akt through the epidermal_growth_factor_receptor pathway and abrogates the effect of gefitinib .
19153210	0	Akt	21,24	epidermal_growth_factor_receptor	91,123	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|transactivation transactivation|compound|END_ENTITY	Obestatin stimulates Akt signalling in gastric_cancer cells through beta-arrestin-mediated epidermal_growth_factor_receptor transactivation .
20103665	0	Akt	116,119	epidermal_growth_factor_receptor	22,54	Akt	epidermal growth factor receptor	11651(Tax:10090)	13649(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY mediated|nmod|inhibition Radiosensitization|parataxis|mediated Radiosensitization|nmod|END_ENTITY	Radiosensitization of epidermal_growth_factor_receptor / HER2-positive pancreatic_cancer is mediated by inhibition of Akt independent of ras mutational status .
20506627	0	Akt	53,56	epidermal_growth_factor_receptor	79,111	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	Cobalt_chloride stimulates phosphoinositide_3-kinase / Akt signaling through the epidermal_growth_factor_receptor in oral_squamous_cell_carcinoma .
21040950	0	Akt	81,84	epidermal_growth_factor_receptor	48,80	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	Paradigm|dep|START_ENTITY Paradigm|nmod|END_ENTITY	Paradigm of kinase-driven pathway downstream of epidermal_growth_factor_receptor / Akt in human lung_carcinomas .
21057220	0	Akt	105,108	epidermal_growth_factor_receptor	21,53	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|mutations mutations|compound|END_ENTITY	Prognostic effect of epidermal_growth_factor_receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian_cancer .
25338626	0	Akt	94,97	epidermal_growth_factor_receptor	59,91	Akt	epidermal growth factor receptor	11651(Tax:10090)	13649(Tax:10090)	Gene	Gene	bortezomib|compound|START_ENTITY END_ENTITY|dep|bortezomib	Reactive oxygen species - mediated activation of the Src - epidermal_growth_factor_receptor - Akt signaling cascade prevents bortezomib - induced apoptosis in hepatocellular_carcinoma cells .
26617770	0	Akt	82,85	epidermal_growth_factor_receptor	123,155	Akt	epidermal growth factor receptor	207	1956	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-133b inhibits proliferation and invasion of ovarian_cancer cells through Akt and Erk1/2 inactivation by targeting epidermal_growth_factor_receptor .
15302785	0	Akt	115,118	erythropoietin	38,52	Akt	erythropoietin	207	2056	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|therapy therapy|nmod|analogue analogue|compound|END_ENTITY	Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure .
16107690	0	Akt	30,33	erythropoietin	45,59	Akt	erythropoietin	11651(Tax:10090)	13856(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Phosphatidylinositol_3-kinase / Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation .
16918383	0	Akt	76,79	erythropoietin	38,52	Akt	erythropoietin	207	2056	Gene	Gene	integration|nmod|START_ENTITY maintained|nmod|integration maintained|nmod|END_ENTITY	Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen_synthase_kinase-3beta , beta-catenin , and nuclear factor-kappaB .
18346168	0	Akt	81,84	erythropoietin	30,44	Akt	erythropoietin	24185(Tax:10116)	24335(Tax:10116)	Gene	Gene	translocation|nmod|START_ENTITY associated|nmod|translocation associated|nsubjpass|Limitation Limitation|nmod|size size|nmod|END_ENTITY	Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion .
23337206	0	Akt	89,92	erythropoietin	51,65	Akt	erythropoietin	207	2056	Gene	Gene	phosphorylation|compound|START_ENTITY suppression|nmod|phosphorylation counteracts|nmod|suppression counteracts|dobj|effects effects|nmod|END_ENTITY	Indoxyl_sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation .
17384257	0	Akt	61,64	extracellular_signal-regulated_kinase	23,60	Akt	extracellular signal-regulated kinase	11651(Tax:10090)	26413(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Caspase activation and extracellular_signal-regulated_kinase / Akt inhibition were involved in luteolin-induced apoptosis in Lewis_lung_carcinoma cells .
17410645	0	Akt	61,64	extracellular_signal-regulated_kinase	23,60	Akt	extracellular signal-regulated kinase	11651(Tax:10090)	26413(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Caspase activation and extracellular_signal-regulated_kinase / Akt inhibition were involved in luteolin-induced apoptosis in Lewis_lung_carcinoma cells .
18948272	0	Akt	138,141	focal_adhesion_kinase	110,131	Akt	focal adhesion kinase	207	5747	Gene	Gene	proliferation|dep|START_ENTITY proliferation|nmod|END_ENTITY	MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 -LRB- MLC2 -RRB- / focal_adhesion_kinase -LRB- FAK -RRB- / Akt signaling pathway .
21209368	0	Akt	0,3	focal_adhesion_kinase	23,44	Akt	focal adhesion kinase	207	5747	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Akt directly regulates focal_adhesion_kinase through association and serine phosphorylation : implication for pressure-induced colon_cancer metastasis .
16442704	0	Akt	93,96	gastrin	17,24	Akt	gastrin	207	2520	Gene	Gene	pathways|compound|START_ENTITY activation|nmod|pathways cells|nmod|activation apoptosis|nmod|cells inhibits|dobj|apoptosis inhibits|nsubj|END_ENTITY	Glycine-extended gastrin inhibits apoptosis in colon_cancer cells via separate activation of Akt and JNK pathways .
19262695	0	Akt	16,19	ghrelin	45,52	Akt	ghrelin	207	58991(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and - dependent mechanisms .
22147269	0	Akt	68,71	heme_oxygenase-1	16,32	Akt	heme oxygenase-1	24185(Tax:10116)	24451(Tax:10116)	Gene	Gene	confer|nsubj|START_ENTITY Upregulation|parataxis|confer Upregulation|nmod|END_ENTITY	Upregulation of heme_oxygenase-1 by acteoside through ERK and PI3_K / Akt pathway confer neuroprotection against beta-amyloid-induced neurotoxicity .
15683732	0	Akt	75,78	hepatocyte_growth_factor	38,62	Akt	hepatocyte growth factor	207	3082	Gene	Gene	up-regulation|amod|START_ENTITY inhibited|nmod|up-regulation inhibited|nmod|END_ENTITY	Trophoblast apoptosis is inhibited by hepatocyte_growth_factor through the Akt and beta-catenin mediated up-regulation of inducible_nitric_oxide_synthase .
24634221	0	Akt	51,54	hepatocyte_growth_factor	68,92	Akt	hepatocyte growth factor	207	3082	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Role of c-Met/phosphatidylinositol _ 3-kinase -LRB- PI3k -RRB- / Akt signaling in hepatocyte_growth_factor -LRB- HGF -RRB- - mediated lamellipodia formation , reactive oxygen species -LRB- ROS -RRB- generation , and motility of lung endothelial cells .
26256949	0	Akt	101,104	hypoxia-inducible_factor-1a	73,100	Akt	hypoxia-inducible factor-1a	207	3091	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Hypoxia-mediated cancer stem cells in pseudopalisades with activation of hypoxia-inducible_factor-1a / Akt axis in glioblastoma .
15683732	0	Akt	75,78	inducible_nitric_oxide_synthase	122,153	Akt	inducible nitric oxide synthase	207	4843	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Trophoblast apoptosis is inhibited by hepatocyte_growth_factor through the Akt and beta-catenin mediated up-regulation of inducible_nitric_oxide_synthase .
11042022	0	Akt	0,3	insulin	13,20	Akt	insulin	207	3630	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|rescue rescue|compound|END_ENTITY	Akt mediates insulin rescue from apoptosis in brown adipocytes : effect of ceramide .
11788651	0	Akt	86,89	insulin	19,26	Akt	insulin	207	3630	Gene	Gene	phosphorylation|amod|START_ENTITY activation|nmod|phosphorylation resistance|dep|activation resistance|compound|END_ENTITY	Fatty_acid-induced insulin resistance : decreased muscle PI3K activation but unchanged Akt phosphorylation .
15194686	0	Akt	52,55	insulin	104,111	Akt	insulin	207	3630	Gene	Gene	substrate|compound|START_ENTITY substrate|acl|involved involved|nmod|action action|nmod|END_ENTITY	Insulin-response element-binding protein 1 : a novel Akt substrate involved in transcriptional action of insulin .
17028898	0	Akt	107,110	insulin	12,19	Akt	insulin	207	3630	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|defects defects|compound|END_ENTITY	Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein_kinase_B / Akt in muscles of obese_diabetic_humans .
17053882	0	Akt	35,38	insulin	10,17	Akt	insulin	207	3630	Gene	Gene	survival|compound|START_ENTITY activates|dobj|survival activates|nsubj|action action|compound|END_ENTITY	Autocrine insulin action activates Akt and increases survival of isolated human islets .
17130464	0	Akt	53,56	insulin	89,96	Akt	insulin	24185(Tax:10116)	3630	Gene	Gene	PRAS40|compound|START_ENTITY phosphorylation|nmod|PRAS40 impaired|nsubjpass|phosphorylation impaired|nmod|tissues tissues|compound|END_ENTITY	Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats .
21558470	0	Akt	27,30	insulin	112,119	Akt	insulin	24185(Tax:10116)	3630	Gene	Gene	phosphorylation|nmod|START_ENTITY and_liver|nmod|phosphorylation and_liver|nmod|END_ENTITY	In situ phosphorylation of Akt and ERK1/2 in rat mammary gland , colon , _ and_liver following treatment with human insulin and IGF-1 .
23092880	0	Akt	53,56	insulin	27,34	Akt	insulin	207	3630	Gene	Gene	regulate|nmod|START_ENTITY regulate|dobj|secretion secretion|compound|END_ENTITY	mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells .
23710710	0	Akt	83,86	insulin-like_growth_factor_1_receptor	45,82	Akt	insulin-like growth factor 1 receptor	207	3480	Gene	Gene	cell|compound|START_ENTITY cell|amod|END_ENTITY	Heterogeneity_of_neuroblastoma cell lines in insulin-like_growth_factor_1_receptor / Akt pathway-mediated cell proliferative responses .
16478996	0	Akt	58,61	insulin-like_growth_factor_I_receptor	4,41	Akt	insulin-like growth factor I receptor	11651(Tax:10090)	16001(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	The insulin-like_growth_factor_I_receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase .
22967108	0	Akt	147,150	leptin	94,100	Akt	leptin	24185(Tax:10116)	25608(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY involve|dobj|activation regulator|acl:relcl|involve regulator|nmod|pathway pathway|nmod|signalling signalling|compound|END_ENTITY	Phosphatidylinositol_3-kinase is an upstream regulator of the phosphodiesterase_3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus .
12773158	0	Akt	99,102	mTOR	145,149	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY connect|dobj|pathway connect|nmod|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	United at last : the tuberous_sclerosis complex gene products connect the phosphoinositide_3-kinase / Akt pathway to mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling .
15585641	0	Akt	93,96	mTOR	14,18	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	Activity|compound|START_ENTITY restores|nmod|Activity restores|nsubj|Inhibition Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of mTOR activity restores tamoxifen response in breast_cancer cells with aberrant Akt Activity .
16452206	0	Akt	82,85	mTOR	0,4	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	signaling|dobj|START_ENTITY induces|xcomp|signaling induces|nsubj|inhibition inhibition|compound|END_ENTITY	mTOR inhibition induces upstream receptor_tyrosine_kinase signaling and activates Akt .
17121917	0	Akt	75,78	mTOR	46,50	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY inhibition|nmod|signaling mammalian_target_of_rapamycin|dep|inhibition mammalian_target_of_rapamycin|appos|END_ENTITY	Statins induce mammalian_target_of_rapamycin -LRB- mTOR -RRB- - mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs .
17878402	0	Akt	88,91	mTOR	31,35	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|inhibition inhibition|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition activates phosphatidylinositol_3-kinase / Akt by up-regulating insulin-like_growth_factor-1 receptor signaling in acute_myeloid_leukemia : rationale for therapeutic inhibition of both pathways .
18377870	0	Akt	0,3	mTOR	94,98	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY protects|nsubj|activation protects|nmod|stimulation stimulation|nmod|END_ENTITY	Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR .
18794129	0	Akt	143,146	mTOR	41,45	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY preventing|dobj|activation therapy|acl|preventing mammalian_target_of_rapamycin|dep|therapy mammalian_target_of_rapamycin|appos|END_ENTITY	Enhancing mammalian_target_of_rapamycin -LRB- mTOR -RRB- - targeted cancer therapy by preventing mTOR/raptor inhibition-initiated , mTOR/rictor-independent Akt activation .
19176518	0	Akt	54,57	mTOR	16,20	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	PKC|nmod|START_ENTITY END_ENTITY|nmod|PKC	EGFR signals to mTOR through PKC and independently of Akt in glioma .
19530170	0	Akt	20,23	mTOR	80,84	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|branching branching|nmod|END_ENTITY	Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1 , respectively .
20356670	0	Akt	27,30	mTOR	46,50	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|response response|nmod|inhibitors inhibitors|compound|END_ENTITY	Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine_tumor_disease .
22338016	0	Akt	0,3	mTOR	47,51	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|ccomp|overcome overcome|dobj|resistance resistance|compound|END_ENTITY	Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse_large_B-cell_lymphoma .
22657251	0	Akt	0,3	mTOR	75,79	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	isoform|nsubj|START_ENTITY isoform|dobj|downstream downstream|nmod|END_ENTITY	Akt -LRB- protein_kinase_B -RRB- isoform phosphorylation and signaling downstream of mTOR -LRB- mammalian_target_of_rapamycin -RRB- in denervated atrophic and hypertrophic mouse skeletal muscle .
22684558	0	Akt	137,140	mTOR	55,59	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY improves|nmod|phosphorylation improves|dobj|effect effect|nmod|shRNA shRNA|compound|END_ENTITY	Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian_cancer cells by down-regulating Akt phosphorylation .
23673367	0	Akt	24,27	mTOR	0,4	Akt	mTOR	207	21977(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	mTOR complex 2 mediates Akt phosphorylation that requires PKC _ in adult cardiac muscle cells .
23942361	0	Akt	0,3	mTOR	89,93	Akt	mTOR	24185(Tax:10116)	21977(Tax:10090)	Gene	Gene	isoforms|compound|START_ENTITY protect|nsubj|isoforms protect|advcl|regulating regulating|dobj|activities activities|compound|END_ENTITY	Akt isoforms differentially protect against stroke-induced neuronal_injury by regulating mTOR activities .
25534823	0	Akt	0,3	mTOR	21,25	Akt	mTOR	11651(Tax:10090)	21977(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Akt - or MEK-mediated mTOR inhibition suppresses Nf1 optic_glioma growth .
23092880	0	Akt	53,56	mTORC1	0,6	Akt	mTORC1	207	382056(Tax:10090)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells .
17011481	0	Akt	26,29	mTORC2	0,6	Akt	mTORC2	207	74343(Tax:10090)	Gene	Gene	Caught|nmod|START_ENTITY Caught|compound|END_ENTITY	mTORC2 Caught in a SINful Akt .
19641186	0	Akt	121,124	mTORC2	143,149	Akt	mTORC2	207	74343(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse_large_B-cell_lymphoma by inhibiting Akt signaling through mTORC2 .
21045808	0	Akt	104,107	mTORC2	0,6	Akt	mTORC2	207	74343(Tax:10090)	Gene	Gene	polypeptide|compound|START_ENTITY phosphorylation|nmod|polypeptide promote|dobj|phosphorylation associate|xcomp|promote associate|nsubj|END_ENTITY	mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide .
21956113	0	Akt	103,106	mTORC2	146,152	Akt	mTORC2	207	74343(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY dependent|nmod|protein dependent|ccomp|serine serine|dobj|phosphorylation phosphorylation|nmod|protein protein|amod|END_ENTITY	Mechanical regulation of glycogen_synthase_kinase_3b -LRB- GSK3b -RRB- in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein .
22084251	0	Akt	125,128	mTORC2	88,94	Akt	mTORC2	207	74343(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY phosphorylation|nmod|protein acetylation|dep|phosphorylation acetylation|nmod|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	Multiple site acetylation of Rictor stimulates mammalian_target_of_rapamycin complex 2 -LRB- mTORC2 -RRB- - dependent phosphorylation of Akt protein .
22521878	0	Akt	60,63	mTORC2	8,14	Akt	mTORC2	11651(Tax:10090)	74343(Tax:10090)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Hepatic mTORC2 activates glycolysis and lipogenesis through Akt , glucokinase , and SREBP1c .
23684622	0	Akt	47,50	mTORC2	70,76	Akt	mTORC2	207	74343(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2 .
12773158	0	Akt	99,102	mammalian_target_of_rapamycin	114,143	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	pathway|compound|START_ENTITY connect|dobj|pathway connect|nmod|END_ENTITY	United at last : the tuberous_sclerosis complex gene products connect the phosphoinositide_3-kinase / Akt pathway to mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling .
16027121	0	Akt	0,3	mammalian_target_of_rapamycin	18,47	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Akt activates the mammalian_target_of_rapamycin by regulating cellular ATP level and AMPK activity .
16103051	0	Akt	14,17	mammalian_target_of_rapamycin	68,97	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	Activation|nmod|START_ENTITY pathways|nsubj|Activation pathways|nmod|inhibition inhibition|compound|END_ENTITY	Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian_target_of_rapamycin inhibition .
16140948	0	Akt	114,117	mammalian_target_of_rapamycin	14,43	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	nutrient|nmod|START_ENTITY nutrient|nsubj|Activation Activation|nmod|END_ENTITY	Activation of mammalian_target_of_rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt , mitogen-activated protein kinase/extracellular signal-regulated kinase kinase , insulin growth factor-I , and serum .
17121917	0	Akt	75,78	mammalian_target_of_rapamycin	15,44	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	signaling|compound|START_ENTITY inhibition|nmod|signaling END_ENTITY|dep|inhibition	Statins induce mammalian_target_of_rapamycin -LRB- mTOR -RRB- - mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs .
18045951	0	Akt	53,56	mammalian_target_of_rapamycin	73,102	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	signals|nmod|START_ENTITY signals|xcomp|activate activate|dobj|END_ENTITY	Adiponectin signals in prostate_cancer cells through Akt to activate the mammalian_target_of_rapamycin pathway .
18490760	0	Akt	147,150	mammalian_target_of_rapamycin	92,121	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	determined|nmod|START_ENTITY activation|acl|determined activation|compound|END_ENTITY	Differential involvement of IkappaB kinases alpha and beta in cytokine - and insulin-induced mammalian_target_of_rapamycin activation determined by Akt .
18566586	0	Akt	78,81	mammalian_target_of_rapamycin	4,33	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	folding|nmod|START_ENTITY controls|dobj|folding controls|nsubj|END_ENTITY	The mammalian_target_of_rapamycin complex 2 controls folding and stability of Akt and protein_kinase_C .
18794129	0	Akt	143,146	mammalian_target_of_rapamycin	10,39	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	activation|compound|START_ENTITY preventing|dobj|activation therapy|acl|preventing END_ENTITY|dep|therapy	Enhancing mammalian_target_of_rapamycin -LRB- mTOR -RRB- - targeted cancer therapy by preventing mTOR/raptor inhibition-initiated , mTOR/rictor-independent Akt activation .
19474313	0	Akt	0,3	mammalian_target_of_rapamycin	24,53	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|pathway pathway|compound|END_ENTITY	Akt signals through the mammalian_target_of_rapamycin pathway to regulate CNS myelination .
22084251	0	Akt	125,128	mammalian_target_of_rapamycin	47,76	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	protein|compound|START_ENTITY phosphorylation|nmod|protein acetylation|dep|phosphorylation acetylation|nmod|END_ENTITY	Multiple site acetylation of Rictor stimulates mammalian_target_of_rapamycin complex 2 -LRB- mTORC2 -RRB- - dependent phosphorylation of Akt protein .
22657251	0	Akt	0,3	mammalian_target_of_rapamycin	81,110	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	isoform|nsubj|START_ENTITY isoform|dobj|downstream downstream|nmod|mTOR mTOR|appos|END_ENTITY	Akt -LRB- protein_kinase_B -RRB- isoform phosphorylation and signaling downstream of mTOR -LRB- mammalian_target_of_rapamycin -RRB- in denervated atrophic and hypertrophic mouse skeletal muscle .
23920219	0	Akt	129,132	mammalian_target_of_rapamycin	153,182	Akt	mammalian target of rapamycin	207	2475	Gene	Gene	3-kinase|appos|START_ENTITY 3-kinase|acl|END_ENTITY	Insights into insulin-mediated regulation of CYP2E1 : miR-132 / -212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase , Akt -LRB- protein_kinase_B -RRB- , mammalian_target_of_rapamycin signaling in regulating miR-132 / -212 and miR-122 / -181 a expression in primary cultured rat hepatocytes .
19062713	0	Akt	17,20	mdm2	22,26	Akt	mdm2	207	4193	Gene	Gene	Impact|dep|START_ENTITY END_ENTITY|nsubj|Impact	-LSB- Impact of PI3K / Akt / mdm2 signaling pathway on the sensitivity of gastric_cancer cell line SGC7901 to doxorubicin -RSB- .
12767043	0	Akt	37,40	nerve_growth_factor	89,108	Akt	nerve growth factor	24185(Tax:10116)	310738(Tax:10116)	Gene	Gene	translocates|compound|START_ENTITY form|nmod|translocates phosphorylated|dobj|form phosphorylated|nmod|stimulation stimulation|compound|END_ENTITY	Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve_growth_factor stimulation and associates with the nuclear matrix protein nucleolin .
19996110	0	Akt	93,96	nerve_growth_factor	11,30	Akt	nerve growth factor	207	4803	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Endogenous nerve_growth_factor regulates collagen expression and bladder_hypertrophy through Akt and MAPK pathways during cystitis .
22026649	0	Akt	92,95	norepinephrine_transporter	61,87	Akt	norepinephrine transporter	24185(Tax:10116)	83511(Tax:10116)	Gene	Gene	pathways|amod|START_ENTITY END_ENTITY|nmod|pathways	Angiotensin - -LRB- 1-7 -RRB- through Mas receptor up-regulates neuronal norepinephrine_transporter via Akt and Erk1/2-dependent pathways .
20667469	0	Akt	46,49	p110a	11,16	Akt	p110a	207	5290	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	PI3-kinase p110a mediates b1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading .
24726838	0	Akt	31,34	p150	58,62	Akt	p150	207	10036	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Microtubule dynamics regulates Akt signaling via dynactin p150 .
21617849	0	Akt	54,57	p21	90,93	Akt	p21	207	644914	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21 -LRB- cip -RRB- .
21671244	0	Akt	17,20	p21	110,113	Akt	p21	11651(Tax:10090)	12575(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|advcl|changing changing|dobj|localization localization|nmod|END_ENTITY	Protein_kinase_B / Akt may regulate G2/M transition in the fertilized mouse egg by changing the localization of p21 -LRB- Cip1/WAF1 -RRB- .
26030190	0	Akt	18,21	p21	91,94	Akt	p21	207	1026	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|counter-regulation counter-regulation|nmod|END_ENTITY	Nuclear localized Akt enhances breast_cancer stem-like cells through counter-regulation of p21 -LRB- Waf1/Cip1 -RRB- and p27 -LRB- kip1 -RRB- .
16024795	0	Akt	0,3	p300	23,27	Akt	p300	207	2033	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity .
11042204	0	Akt	97,100	p38	0,3	Akt	p38	207	1432	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils .
11259436	0	Akt	0,3	p38	181,184	Akt	p38	207	1432	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|potential potential|nmod|Subunit Subunit|nmod|END_ENTITY	Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa_B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38 .
11387313	0	Akt	0,3	p38	23,26	Akt	p38	207	1432	Gene	Gene	down-regulation|compound|START_ENTITY down-regulation|nmod|signaling signaling|amod|END_ENTITY	Akt down-regulation of p38 signaling provides a novel mechanism of vascular_endothelial_growth_factor-mediated cytoprotection in endothelial cells .
12824193	0	Akt	120,123	p38	89,92	Akt	p38	207	5594	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway activation|nmod|MAPK MAPK|amod|END_ENTITY	Protein_kinase_C promotes apoptosis in LNCaP_prostate_cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway .
12914935	0	Akt	52,55	p38	33,36	Akt	p38	207	5594	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	IL-4 augments anisomycin-induced p38 activation via Akt pathway in a follicular_dendritic_cell -LRB- FDC -RRB- - like line .
12972603	0	Akt	70,73	p38	30,33	Akt	p38	207	1432	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Regulation Regulation|nmod|activity activity|nmod|protein protein|amod|END_ENTITY	Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis .
15084475	0	Akt	57,60	p38	8,11	Akt	p38	207	1432	Gene	Gene	activation|compound|START_ENTITY Role|nmod|activation Role|nmod|MAPK MAPK|amod|END_ENTITY	Role of p38 MAPK and MAPKAPK-2 in angiotensin_II-induced Akt activation in vascular smooth muscle cells .
15381256	0	Akt	26,29	p38	4,7	Akt	p38	11651(Tax:10090)	26416(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|pathway pathway|amod|END_ENTITY	The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis .
15848222	0	Akt	0,3	p38	120,123	Akt	p38	24185(Tax:10116)	81649(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|parataxis|downstream downstream|nmod|kinase kinase|amod|END_ENTITY	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells : function at a point downstream from p38 MAP kinase .
15980035	0	Akt	85,88	p38	0,3	Akt	p38	207	1432	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway required|nsubjpass|activation END_ENTITY|acl:relcl|required	p38 and EGF_receptor kinase-mediated activation of the phosphatidylinositol_3-kinase / Akt pathway is required for Zn2 + - induced cyclooxygenase-2 expression .
24650887	0	Akt	214,217	p38	209,212	Akt	p38	11651(Tax:10090)	26416(Tax:10090)	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
16613850	0	Akt	0,3	p52	67,70	Akt	p52	11651(Tax:10090)	18034(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Akt regulates basal and induced processing of NF-kappaB2 -LRB- p100 -RRB- to p52 .
23421998	0	Akt	45,48	p57	14,17	Akt	p57	207	1028	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nsubjpass|END_ENTITY	CDK inhibitor p57 -LRB- Kip2 -RRB- is downregulated by Akt during HER2-mediated tumorigenicity .
16011831	0	Akt	14,17	p62	0,3	Akt	p62	207	23636	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation .
19117013	0	Akt	102,105	phosphatidylinositol-3-kinase	72,101	Akt	phosphatidylinositol-3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY glycoprotein|parataxis|signaling glycoprotein|acl:relcl|activate activate|xcomp|END_ENTITY	Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase / Akt signaling in skeletal muscle in a laminin-dependent manner .
24273605	0	Akt	109,112	phosphatidylinositol-3-kinase	79,108	Akt	phosphatidylinositol-3-kinase	207	5293	Gene	Gene	transduction|compound|START_ENTITY transduction|amod|END_ENTITY	Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase / Akt signal transduction in gastric_cancer cells .
16370391	0	Akt	44,47	phosphatidylinositol-3_kinase	14,43	Akt	phosphatidylinositol-3 kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Targeting the phosphatidylinositol-3_kinase / Akt pathway for the treatment of cancer .
18544676	0	Akt	121,124	phosphatidylinositol-3_kinase	91,120	Akt	phosphatidylinositol-3 kinase	24185(Tax:10116)	85243(Tax:10116)	Gene	Gene	pathways|dep|START_ENTITY pathways|amod|END_ENTITY	Lithium protection of phencyclidine-induced neurotoxicity in developing brain : the role of phosphatidylinositol-3_kinase / Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways .
19065678	0	Akt	111,114	phosphatidylinositol-3_kinase	22,51	Akt	phosphatidylinositol-3 kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	modulate|nsubj|START_ENTITY phosphoinositide-dependent_protein_kinase_1|dep|modulate size|amod|phosphoinositide-dependent_protein_kinase_1 size|amod|END_ENTITY	The survival pathways phosphatidylinositol-3_kinase -LRB- PI3-K -RRB- / phosphoinositide-dependent_protein_kinase_1 -LRB- PDK1 -RRB- / Akt modulate liver_regeneration through hepatocyte size rather than proliferation .
20578891	0	Akt	57,60	phosphatidylinositol-3_kinase	27,56	Akt	phosphatidylinositol-3 kinase	207	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Genetic alterations in the phosphatidylinositol-3_kinase / Akt pathway in thyroid_cancer .
24524196	0	Akt	99,102	phosphatidylinositol-3_kinase	69,98	Akt	phosphatidylinositol-3 kinase	207	5290	Gene	Gene	signals|compound|START_ENTITY signals|amod|END_ENTITY	Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3_kinase / Akt signals .
11067939	0	Akt	191,194	phosphatidylinositol_3-kinase	161,190	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	up-stream|compound|START_ENTITY up-stream|amod|END_ENTITY	Inhibition of TNF-alpha-induced neutrophil apoptosis by crystals of calcium_pyrophosphate_dihydrate is mediated by the extracellular signal-regulated kinase and phosphatidylinositol_3-kinase / Akt pathways up-stream of caspase_3 .
11278333	0	Akt	48,51	phosphatidylinositol_3-kinase	18,47	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Activation of the phosphatidylinositol_3-kinase / Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis .
11294857	0	Akt	68,71	phosphatidylinositol_3-kinase	38,67	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Hypoxia induces the activation of the phosphatidylinositol_3-kinase / Akt cell survival pathway in PC12 cells : protective role in apoptosis .
11356694	0	Akt	84,87	phosphatidylinositol_3-kinase	54,83	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	X-linked_inhibitor_of_apoptosis_protein activates the phosphatidylinositol_3-kinase / Akt pathway in rat granulosa cells during follicular development .
11368352	0	Akt	13,16	phosphatidylinositol_3-kinase	86,115	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY Induction|nmod|phosphorylation occurs|nsubj|Induction occurs|advmod|upstream upstream|advcl|END_ENTITY	Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol_3-kinase : no evidence for oxidative inhibition of PTEN .
11479306	0	Akt	92,95	phosphatidylinositol_3-kinase	62,91	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	Cyclic_AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol_3-kinase / Akt pathways by inhibiting Rap1 .
11585835	1	Akt	148,151	phosphatidylinositol_3-kinase	118,147	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Involvement of phosphatidylinositol_3-kinase / Akt pathway .
11593409	0	Akt	87,90	phosphatidylinositol_3-kinase	57,86	Akt	phosphatidylinositol 3-kinase	207	18708(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol_3-kinase / Akt activation by growth factors .
12032135	0	Akt	53,56	phosphatidylinositol_3-kinase	23,52	Akt	phosphatidylinositol 3-kinase	207	5294	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Down-regulation of the phosphatidylinositol_3-kinase / Akt pathway is involved in retinoic_acid-induced phosphorylation , degradation , and transcriptional activity of retinoic_acid receptor gamma 2 .
12130673	0	Akt	129,132	phosphatidylinositol_3-kinase	99,128	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Insulin-like_growth_factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol_3-kinase / Akt kinase and role of this pathway in insulin-like_growth_factor-1-induced survival of cultured hippocampal neurons .
12446712	0	Akt	96,99	phosphatidylinositol_3-kinase	66,95	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	remodeling|dep|START_ENTITY remodeling|amod|END_ENTITY	Epstein-Barr_virus latent membrane protein 1 -LRB- LMP1 -RRB- activates the phosphatidylinositol_3-kinase / Akt pathway to promote cell survival and induce actin filament remodeling .
12591985	0	Akt	57,60	phosphatidylinositol_3-kinase	27,56	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of deguelin on the phosphatidylinositol_3-kinase / Akt pathway and apoptosis in premalignant human bronchial epithelial cells .
12624428	0	Akt	38,41	phosphatidylinositol_3-kinase	8,37	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Role of phosphatidylinositol_3-kinase / Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric_oxide synthase in vascular smooth muscle cells .
12637493	0	Akt	59,62	phosphatidylinositol_3-kinase	29,58	Akt	phosphatidylinositol 3-kinase	207	5295	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	CD40-dependent activation of phosphatidylinositol_3-kinase / Akt pathway mediates endothelial cell survival and in vitro angiogenesis .
12640124	0	Akt	65,68	phosphatidylinositol_3-kinase	35,64	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Caveolin-induced activation of the phosphatidylinositol_3-kinase / Akt pathway increases arsenite cytotoxicity .
12952968	0	Akt	114,117	phosphatidylinositol_3-kinase	84,113	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Epidermal_growth_factor_receptor-dependent , NF-kappaB-independent activation of the phosphatidylinositol_3-kinase / Akt pathway inhibits ultraviolet irradiation-induced caspases-3 , _ -8 , _ and _ -9 in human keratinocytes .
14555644	0	Akt	97,100	phosphatidylinositol_3-kinase	67,96	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Suppression versus induction of androgen_receptor functions by the phosphatidylinositol_3-kinase / Akt pathway in prostate_cancer LNCaP cells with different passage numbers .
14688281	0	Akt	84,87	phosphatidylinositol_3-kinase	54,83	Akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Regulation of heme_oxygenase-1 expression through the phosphatidylinositol_3-kinase / Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol .
15166238	0	Akt	67,70	phosphatidylinositol_3-kinase	37,66	Akt	phosphatidylinositol 3-kinase	207	5295	Gene	Gene	I|dep|START_ENTITY END_ENTITY|dep|I	Focal_adhesion_kinase is upstream of phosphatidylinositol_3-kinase / Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway .
15706421	0	Akt	45,48	phosphatidylinositol_3-kinase	15,44	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	signaling|compound|START_ENTITY determinant|nsubj|signaling Suppression|parataxis|determinant Suppression|nmod|END_ENTITY	Suppression of phosphatidylinositol_3-kinase / Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor , FK228 , in lung_adenocarcinoma cells .
15890643	0	Akt	247,250	phosphatidylinositol_3-kinase	216,245	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
15980035	0	Akt	85,88	phosphatidylinositol_3-kinase	55,84	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	p38 and EGF_receptor kinase-mediated activation of the phosphatidylinositol_3-kinase / Akt pathway is required for Zn2 + - induced cyclooxygenase-2 expression .
16061480	0	Akt	75,78	phosphatidylinositol_3-kinase	45,74	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	substrate|compound|START_ENTITY Induction|parataxis|substrate Induction|dep|END_ENTITY	Induction of androgen_receptor expression by phosphatidylinositol_3-kinase / Akt downstream substrate , FOXO3a , and their roles in apoptosis of LNCaP_prostate_cancer cells .
16115952	0	Akt	96,99	phosphatidylinositol_3-kinase	66,95	Akt	phosphatidylinositol 3-kinase	207	5295	Gene	Gene	NH2-terminal|amod|START_ENTITY Response|dep|NH2-terminal Response|nmod|inhibitors inhibitors|nmod|END_ENTITY	Response of non-small cell lung_cancer cells to the inhibitors of phosphatidylinositol_3-kinase / Akt - and MAPK kinase 4/c-Jun NH2-terminal kinase pathways : an effective therapeutic strategy for lung_cancer .
16155123	0	Akt	116,119	phosphatidylinositol_3-kinase	86,115	Akt	phosphatidylinositol 3-kinase	41957(Tax:7227)	42446(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol_3-kinase / Akt signaling .
16166311	0	Akt	48,51	phosphatidylinositol_3-kinase	18,47	Akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Inhibition of the phosphatidylinositol_3-kinase / Akt pathway by inositol_pentakisphosphate results in antiangiogenic and antitumor effects .
16546963	0	Akt	48,51	phosphatidylinositol_3-kinase	18,47	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Inhibition of the phosphatidylinositol_3-kinase / Akt pathway sensitizes MDA-MB468 human breast_cancer cells to cerulenin-induced apoptosis .
16650001	0	Akt	155,158	phosphatidylinositol_3-kinase	125,154	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol_3-kinase / Akt pathways .
16700876	0	Akt	123,126	phosphatidylinositol_3-kinase	93,122	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Hyperinsulinaemia increases the gene expression of endothelial nitric_oxide synthase and the phosphatidylinositol_3-kinase / Akt pathway in rat aorta .
16741926	0	Akt	51,54	phosphatidylinositol_3-kinase	14,43	Akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Regulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt and nuclear_factor-kappa_B signaling pathways in dystrophin-deficient_skeletal_muscle in response to mechanical stretch .
16924472	0	Akt	146,149	phosphatidylinositol_3-kinase	116,145	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol_3-kinase / Akt pathway .
17170431	0	Akt	81,84	phosphatidylinositol_3-kinase	44,73	Akt	phosphatidylinositol 3-kinase	207	5295	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
17179158	0	Akt	85,88	phosphatidylinositol_3-kinase	45,74	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	integrates|nmod|START_ENTITY integrates|dobj|signal signal|amod|END_ENTITY	Statin-induced Ras activation integrates the phosphatidylinositol_3-kinase signal to Akt and MAPK for bone_morphogenetic_protein-2 expression in osteoblast differentiation .
17317825	0	Akt	80,83	phosphatidylinositol_3-kinase	50,79	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Genetic alterations and their relationship in the phosphatidylinositol_3-kinase / Akt pathway in thyroid_cancer .
17325368	0	Akt	44,47	phosphatidylinositol_3-kinase	14,43	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Effect of the phosphatidylinositol_3-kinase / Akt pathway on influenza_A_virus_propagation .
17640564	0	Akt	87,90	phosphatidylinositol_3-kinase	57,86	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	involved|nsubjpass|START_ENTITY Up-regulation|parataxis|involved Up-regulation|acl|mediated mediated|advcl|END_ENTITY	Up-regulation of aldose reductase expression mediated by phosphatidylinositol_3-kinase / Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage .
17896924	0	Akt	79,82	phosphatidylinositol_3-kinase	49,78	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Cross-talk between the androgen_receptor and the phosphatidylinositol_3-kinase / Akt pathway in prostate_cancer .
18198183	0	Akt	82,85	phosphatidylinositol_3-kinase	52,81	Akt	phosphatidylinositol 3-kinase	399170(Tax:8355)	373752(Tax:8355)	Gene	Gene	signal|compound|START_ENTITY signal|amod|END_ENTITY	Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol_3-kinase / Akt -LRB- PI3K/Akt -RRB- signal .
18216097	0	Akt	36,39	phosphatidylinositol_3-kinase	6,35	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	activation|compound|START_ENTITY limits|nsubj|activation END_ENTITY|parataxis|limits	Early phosphatidylinositol_3-kinase / Akt pathway activation limits poliovirus-induced JNK-mediated cell death .
18243161	0	Akt	34,37	phosphatidylinositol_3-kinase	4,33	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	The phosphatidylinositol_3-kinase / Akt pathway negatively regulates Nod2-mediated NF-kappaB pathway .
18332138	0	Akt	98,101	phosphatidylinositol_3-kinase	68,97	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	signaling-dependent|dep|START_ENTITY END_ENTITY|parataxis|signaling-dependent	Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol_3-kinase / Akt signaling-dependent .
18400376	0	Akt	132,135	phosphatidylinositol_3-kinase	102,131	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	intracellular|compound|START_ENTITY intracellular|amod|END_ENTITY	The release of fibroblast_growth_factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol_3-kinase / Akt intracellular signaling pathway .
18583416	0	Akt	100,103	phosphatidylinositol_3-kinase	70,99	Akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Modulation of caveolin-1 expression can affect signalling through the phosphatidylinositol_3-kinase / Akt pathway and cellular proliferation in response to insulin-like growth factor I .
19139118	0	Akt	46,49	phosphatidylinositol_3-kinase	16,45	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	START_ENTITY|dep|Synergy Synergy|dep|END_ENTITY	Synergy between phosphatidylinositol_3-kinase / Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung .
19458286	0	Akt	203,206	phosphatidylinositol_3-kinase	173,202	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	-LRB- S -RRB- -1 - -LRB- alpha-naphthylmethyl -RRB- -6,7 - dihydroxy-1 ,2,3,4 - tetrahydroisoquinoline -LRB- CKD712 -RRB- reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of phosphatidylinositol_3-kinase / Akt signaling and anti-inflammatory action in vivo .
19464003	0	Akt	49,52	phosphatidylinositol_3-kinase	19,48	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	signaling|compound|START_ENTITY signaling|dep|related related|advcl|END_ENTITY	Changes related to phosphatidylinositol_3-kinase / Akt signaling in leiomyomas : possible involvement of glycogen_synthase_kinase_3alpha and cyclin_D2 in the pathophysiology .
19584267	0	Akt	147,150	phosphatidylinositol_3-kinase	117,146	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Parathyroid_hormone-related_protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol_3-kinase / Akt signaling .
19661335	0	Akt	149,152	phosphatidylinositol_3-kinase	112,141	Akt	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
20028853	0	Akt	59,62	phosphatidylinositol_3-kinase	29,58	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	signaling|compound|START_ENTITY inhibit|nsubj|signaling inhibitors|parataxis|inhibit inhibitors|nmod|END_ENTITY	Small-molecule inhibitors of phosphatidylinositol_3-kinase / Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth .
20388520	0	Akt	145,148	phosphatidylinositol_3-kinase	115,144	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	mechanism|dep|START_ENTITY mechanism|amod|END_ENTITY	Inflammation and apoptosis in aortic tissues of aged type_II_diabetes : amelioration with alpha-lipoic_acid through phosphatidylinositol_3-kinase / Akt - dependent mechanism .
20406854	0	Akt	204,207	phosphatidylinositol_3-kinase	174,203	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	The farnesyltransferase inhibitor LB42708 suppresses vascular_endothelial_growth_factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol_3-kinase / Akt signal pathways .
20452332	0	Akt	112,115	phosphatidylinositol_3-kinase	82,111	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Meloxicam protects cell damage from 1-methyl-4-phenyl_pyridinium toxicity via the phosphatidylinositol_3-kinase / Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells .
20584208	0	Akt	67,70	phosphatidylinositol_3-kinase	37,66	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	Effects induced by inhibitors of the phosphatidylinositol_3-kinase / Akt and nitric_oxide synthase/guanylyl cyclase pathways on the isometric contraction in rat aorta : a comparative study .
21205925	0	Akt	44,47	phosphatidylinositol_3-kinase	14,43	Akt	phosphatidylinositol 3-kinase	207	5295	Gene	Gene	mediates|compound|START_ENTITY mediates|amod|END_ENTITY	Activation of phosphatidylinositol_3-kinase / Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular_carcinoma cells .
21618507	0	Akt	49,52	phosphatidylinositol_3-kinase	19,48	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY inhibition|parataxis|signaling inhibition|nmod|END_ENTITY	Dual inhibition of phosphatidylinositol_3-kinase / Akt and mammalian_target_of_rapamycin signaling in human nonsmall cell lung_cancer cells by a dietary flavonoid_fisetin .
21908616	0	Akt	24,27	phosphatidylinositol_3-kinase	43,72	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	sustain|nsubj|START_ENTITY sustain|dep|independent independent|nmod|PDK1/mTORC2 PDK1/mTORC2|amod|END_ENTITY	IKBKE protein activates Akt independent of phosphatidylinositol_3-kinase / PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation .
22819846	0	Akt	143,146	phosphatidylinositol_3-kinase	113,142	Akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Hepatoma-derived_growth_factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol_3-kinase / Akt pathway .
23123465	0	Akt	45,48	phosphatidylinositol_3-kinase	15,44	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Involvement of phosphatidylinositol_3-kinase / Akt pathway in gemcitabine-induced apoptosis-like cell death_in_insulinoma cell line INS-1 .
23192871	0	Akt	81,84	phosphatidylinositol_3-kinase	51,80	Akt	phosphatidylinositol 3-kinase	207	5295	Gene	Gene	progression|dep|START_ENTITY progression|amod|END_ENTITY	Varicella-zoster_virus ORF12 protein activates the phosphatidylinositol_3-kinase / Akt pathway to regulate cell cycle progression .
23426129	0	Akt	102,105	phosphatidylinositol_3-kinase	72,101	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Sulforaphane prevents human platelet_aggregation through inhibiting the phosphatidylinositol_3-kinase / Akt pathway .
23687303	0	Akt	46,49	phosphatidylinositol_3-kinase	9,38	Akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY has|nsubj|signaling Enhanced|parataxis|has Enhanced|dep|END_ENTITY	Enhanced phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress .
24080365	0	Akt	239,242	phosphatidylinositol_3-kinase	136,165	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	/|nmod|START_ENTITY /|amod|END_ENTITY	Insulin-like_growth_factor-1_receptor-mediated inhibition of A-type K -LRB- + -RRB- current induces sensory neuronal_hyperexcitability through the phosphatidylinositol_3-kinase and extracellular_signal-regulated_kinase_1 / 2 pathways , independently of Akt .
24338479	0	Akt	61,64	phosphatidylinositol_3-kinase	24,53	Akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling Manipulation|parataxis|regulates Manipulation|nmod|END_ENTITY	Manipulation of cardiac phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling by apoptosis_regulator_through_modulating_IAP_expression -LRB- ARIA -RRB- regulates cardiomyocyte_death during doxorubicin-induced cardiomyopathy .
24566006	0	Akt	150,153	phosphatidylinositol_3-kinase	120,149	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Anti-amyloidogenic effects of ID1201 , the ethanolic extract of the fruits of Melia toosendan , through activation of the phosphatidylinositol_3-kinase / Akt pathway .
25070581	0	Akt	44,47	phosphatidylinositol_3-kinase	14,43	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	signaling|compound|START_ENTITY mediates|nsubj|signaling Activation|parataxis|mediates Activation|nmod|END_ENTITY	Activation of phosphatidylinositol_3-kinase / Akt signaling mediates sorafenib-induced invasion and metastasis in hepatocellular_carcinoma .
26115885	0	Akt	143,146	phosphatidylinositol_3-kinase	88,117	Akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	B|appos|START_ENTITY B|compound|/ /|amod|END_ENTITY	Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / protein kinase B -LRB- Akt -RRB- signaling pathway .
26640543	0	Akt	124,127	phosphatidylinositol_3-kinase	94,123	Akt	phosphatidylinositol 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Inhibition of focal_adhesion_kinase induces apoptosis in bladder_cancer cells via Src and the phosphatidylinositol_3-kinase / Akt pathway .
17302912	0	Akt	76,79	phosphoinositide-3-kinase	50,75	Akt	phosphoinositide-3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	neuroprotective|compound|START_ENTITY neuroprotective|amod|END_ENTITY	Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase / Akt neuroprotective signaling pathway .
18644865	0	Akt	77,80	phosphoinositide-3_kinase	51,76	Akt	phosphoinositide-3 kinase	207	5290	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	The forkhead transcription factor FOXO3a increases phosphoinositide-3_kinase / Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression .
10330402	0	Akt	70,73	phosphoinositide_3-kinase	26,51	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	protein_kinase_B|appos|START_ENTITY protein_kinase_B|amod|END_ENTITY	Changes in the balance of phosphoinositide_3-kinase / protein_kinase_B -LRB- Akt -RRB- and the mitogen-activated protein kinases -LRB- ERK/p38MAPK -RRB- determine a phenotype of visceral and vascular smooth muscle cells .
11062076	0	Akt	54,57	phosphoinositide_3-kinase	28,53	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Peroxynitrite activates the phosphoinositide_3-kinase / Akt pathway in human skin primary fibroblasts .
11815624	0	Akt	70,73	phosphoinositide_3-kinase	44,69	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Lack of evidence for the involvement of the phosphoinositide_3-kinase / Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension .
12738789	0	Akt	82,85	phosphoinositide_3-kinase	56,81	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Bcl-xL mediates a survival mechanism independent of the phosphoinositide_3-kinase / Akt pathway in prostate_cancer cells .
12773158	0	Akt	99,102	phosphoinositide_3-kinase	73,98	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	United at last : the tuberous_sclerosis complex gene products connect the phosphoinositide_3-kinase / Akt pathway to mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling .
12931221	0	Akt	30,33	phosphoinositide_3-kinase	4,29	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	The phosphoinositide_3-kinase / Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- and control of cyclin_D1 expression .
16288212	0	Akt	30,33	phosphoinositide_3-kinase	4,29	Akt	phosphoinositide 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY END_ENTITY|parataxis|essential	The phosphoinositide_3-kinase / Akt pathway is essential for the retinoic_acid-induced differentiation of F9 cells .
16707436	0	Akt	30,33	phosphoinositide_3-kinase	4,29	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	The phosphoinositide_3-kinase / Akt pathway : a new target in human renal_cell_carcinoma therapy .
16751276	0	Akt	76,79	phosphoinositide_3-kinase	50,75	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	signal|compound|START_ENTITY signal|amod|END_ENTITY	Ultrasensitive and absolute quantification of the phosphoinositide_3-kinase / Akt signal transduction pathway by mass spectrometry .
16820027	0	Akt	64,67	phosphoinositide_3-kinase	38,63	Akt	phosphoinositide 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	cascade|compound|START_ENTITY cascade|amod|END_ENTITY	Signalling mechanisms mediated by the phosphoinositide_3-kinase / Akt cascade in synaptic plasticity and memory in the rat .
17537408	0	Akt	147,150	phosphoinositide_3-kinase	121,146	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Osteopontin is a myosphere-derived secretory molecule that promotes angiogenic progenitor cell proliferation through the phosphoinositide_3-kinase / Akt pathway .
17581609	0	Akt	150,153	phosphoinositide_3-kinase	124,149	Akt	phosphoinositide 3-kinase	207	5291	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute_myeloid_leukemia cells via the phosphoinositide_3-kinase / Akt pathway .
18440486	0	Akt	80,83	phosphoinositide_3-kinase	54,79	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Clinicopathological significance of PTEN_loss and the phosphoinositide_3-kinase / Akt pathway in sporadic colorectal_neoplasms : is PTEN_loss predictor of local recurrence ?
18604870	0	Akt	127,130	phosphoinositide_3-kinase	101,126	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Epstein-Barr_virus upregulates phosphorylated heat_shock protein 27 kDa in carcinoma cells using the phosphoinositide_3-kinase / Akt pathway .
18953257	0	Akt	83,86	phosphoinositide_3-kinase	57,82	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide_3-kinase / Akt pathway in human pancreatic_cancer cells .
19706758	0	Akt	146,149	phosphoinositide_3-kinase	27,52	Akt	phosphoinositide 3-kinase	207	5290	Gene	Gene	therapeutic|nmod|START_ENTITY confer|nmod|therapeutic alterations|parataxis|confer alterations|nmod|END_ENTITY	Genetic alterations in the phosphoinositide_3-kinase / Akt signaling pathway confer sensitivity of thyroid_cancer cells to therapeutic targeting of Akt and mammalian_target_of_rapamycin .
19706758	0	Akt	53,56	phosphoinositide_3-kinase	27,52	Akt	phosphoinositide 3-kinase	207	5290	Gene	Gene	signaling|compound|START_ENTITY confer|nsubj|signaling alterations|parataxis|confer alterations|nmod|END_ENTITY	Genetic alterations in the phosphoinositide_3-kinase / Akt signaling pathway confer sensitivity of thyroid_cancer cells to therapeutic targeting of Akt and mammalian_target_of_rapamycin .
20506627	0	Akt	53,56	phosphoinositide_3-kinase	27,52	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Cobalt_chloride stimulates phosphoinositide_3-kinase / Akt signaling through the epidermal_growth_factor_receptor in oral_squamous_cell_carcinoma .
21300751	0	Akt	117,120	phosphoinositide_3-kinase	91,116	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide_3-kinase / Akt signalling .
21695271	0	Akt	118,121	phosphoinositide_3-kinase	92,117	Akt	phosphoinositide 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Anti-malarial drug artesunate attenuates experimental allergic_asthma via inhibition of the phosphoinositide_3-kinase / Akt pathway .
22234835	0	Akt	91,94	phosphoinositide_3-kinase	65,90	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide_3-kinase / Akt pathway in hepatocellular_carcinoma .
23010818	0	Akt	108,111	phosphoinositide_3-kinase	82,107	Akt	phosphoinositide 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY secretion|dep|kinase secretion|nmod|END_ENTITY	Polysaccharide from Ganoderma atrum induces tumor necrosis factor-a secretion via phosphoinositide_3-kinase / Akt , mitogen-activated protein kinase and nuclear factor-kB signaling pathways in RAW264 .7 cells .
24212403	0	Akt	171,174	phosphoinositide_3-kinase	145,170	Akt	phosphoinositide 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	C1q tumor necrosis factor-related protein-3 protects mesenchymal stem cells against hypoxia - and serum deprivation-induced apoptosis through the phosphoinositide_3-kinase / Akt pathway .
24685819	0	Akt	132,135	phosphoinositide_3-kinase	106,131	Akt	phosphoinositide 3-kinase	207	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Endothelium-independent hypoxic contraction of porcine coronary arteries may be mediated by activation of phosphoinositide_3-kinase / Akt pathway .
17172275	0	Akt	45,48	plasminogen_activator_inhibitor_type_1	70,108	Akt	plasminogen activator inhibitor type 1	207	5054	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Phosphatidylinositol_3-kinase / protein kinase Akt negatively regulates plasminogen_activator_inhibitor_type_1 expression in vascular endothelial cells .
26969072	0	Akt	151,154	post-synaptic_density_95	73,97	Akt	post-synaptic density 95	207	1742	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Lambda-cyhalothrin disrupts the up-regulation effect of 17b-estradiol on post-synaptic_density_95 protein expression via estrogen_receptor_a-dependent Akt pathway .
15173318	0	Akt	0,3	prohibitin_2	10,22	Akt	prohibitin 2	11651(Tax:10090)	12034(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Akt binds prohibitin_2 and relieves its repression of MyoD and muscle differentiation .
10467260	0	Akt	18,21	protein_kinase_B	23,39	Akt	protein kinase B	207	2185	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Akt -LRB- protein_kinase_B -RRB- confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli .
11313479	0	Akt	50,53	protein_kinase_B	32,48	Akt	protein kinase B	207	2185	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|import import|nmod|END_ENTITY	Inhibition of nuclear import by protein_kinase_B -LRB- Akt -RRB- regulates the subcellular distribution and activity of the forkhead transcription factor AFX .
11574400	0	Akt	126,129	protein_kinase_B	109,125	Akt	protein kinase B	207	2185	Gene	Gene	START_ENTITY|nsubj|activity activity|dep|not not|nmod|inhibition inhibition|nmod|END_ENTITY	A role for protein phosphatase 2A-like activity , but not atypical protein kinase Czeta , in the inhibition of protein_kinase_B / Akt and glycogen synthesis by palmitate .
11694510	0	Akt	88,91	protein_kinase_B	71,87	Akt	protein kinase B	207	2185	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Inhibition of cAMP-response_element-binding_protein activity decreases protein_kinase_B / Akt expression in 3T3-L1 adipocytes and induces apoptosis .
12082147	0	Akt	53,56	protein_kinase_B	36,52	Akt	protein kinase B	207	2185	Gene	Gene	vesicles|nsubj|START_ENTITY consequence|parataxis|vesicles consequence|acl|targeting targeting|dobj|END_ENTITY	Functional consequence of targeting protein_kinase_B / Akt to GLUT4 vesicles .
12086620	0	Akt	59,62	protein_kinase_B	42,58	Akt	protein kinase B	207	2185	Gene	Gene	mechanism|dep|START_ENTITY mechanism|nmod|regulation regulation|nmod|END_ENTITY	Molecular mechanism for the regulation of protein_kinase_B / Akt by hydrophobic motif phosphorylation .
12479697	0	Akt	44,47	protein_kinase_B	27,43	Akt	protein kinase B	207	2185	Gene	Gene	apoptosis|nsubj|START_ENTITY END_ENTITY|parataxis|apoptosis	Indole-3-carbinol inhibits protein_kinase_B / Akt and induces apoptosis in the human breast_tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line .
14611643	0	Akt	105,108	protein_kinase_B	87,103	Akt	protein kinase B	207	2185	Gene	Gene	substrate|dep|START_ENTITY PKB|dep|substrate PKB|appos|END_ENTITY	WNK1 , the kinase mutated in an inherited_high-blood-pressure_syndrome , is a novel PKB -LRB- protein_kinase_B -RRB- / Akt substrate .
15367694	0	Akt	96,99	protein_kinase_B	101,117	Akt	protein kinase B	207	2185	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Protein phosphatase 2A negatively regulates insulin 's metabolic signaling pathway by inhibiting Akt -LRB- protein_kinase_B -RRB- activity in 3T3-L1 adipocytes .
15583002	0	Akt	45,48	protein_kinase_B	28,44	Akt	protein kinase B	207	2185	Gene	Gene	signaling|compound|START_ENTITY revealed|nsubj|signaling dynamics|parataxis|revealed dynamics|nmod|END_ENTITY	Spatio-temporal dynamics of protein_kinase_B / Akt signaling revealed by a genetically encoded fluorescent reporter .
16397254	0	Akt	114,117	protein_kinase_B	97,113	Akt	protein kinase B	207	2185	Gene	Gene	activation|compound|START_ENTITY dependence|dep|activation dependence|nmod|END_ENTITY	Preferential dependence of breast_cancer cells versus normal cells on integrin-linked_kinase for protein_kinase_B / Akt activation and cell survival .
16619501	0	Akt	65,68	protein_kinase_B	48,64	Akt	protein kinase B	207	2185	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Tumour suppressor PTEN regulates cell cycle and protein_kinase_B / Akt pathway in breast_cancer cells .
17567589	0	Akt	71,74	protein_kinase_B	54,70	Akt	protein kinase B	207	2185	Gene	Gene	involvement|compound|START_ENTITY END_ENTITY|dep|involvement	p53 response to arsenic exposure in epithelial cells : protein_kinase_B / Akt involvement .
18250332	0	Akt	78,81	protein_kinase_B	61,77	Akt	protein kinase B	207	2185	Gene	Gene	inhibits|nsubj|START_ENTITY Phosphorylation|parataxis|inhibits Phosphorylation|dep|receptors receptors|nmod|END_ENTITY	Phosphorylation of inositol_1 ,4,5 - trisphosphate receptors by protein_kinase_B / Akt inhibits Ca2 + release and apoptosis .
19703999	0	Akt	114,117	protein_kinase_B	97,113	Akt	protein kinase B	207	2185	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|binding binding|nmod|kinase kinase|acl:relcl|regulates regulates|dobj|END_ENTITY	Phosphoinositide -LRB- 3,4,5 -RRB- - triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein_kinase_B / Akt signaling threshold that dictates T-cell migration , not proliferation .
21380726	0	Akt	37,40	protein_kinase_B	20,36	Akt	protein kinase B	207	2185	Gene	Gene	signal-regulated|nsubj|START_ENTITY effect|parataxis|signal-regulated effect|nmod|END_ENTITY	Different effect of protein_kinase_B / Akt and extracellular signal-regulated kinase inhibition on trichostatin_A-induced apoptosis in epithelial_ovarian_carcinoma cell lines .
22280833	0	Akt	31,34	protein_kinase_B	14,30	Akt	protein kinase B	207	2185	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of protein_kinase_B / Akt by alpha1-adrenoceptors in the human prostate .
12623995	0	Akt	16,19	protein_kinase_C-alpha	89,111	Akt	protein kinase C-alpha	207	5578	Gene	Gene	activation|compound|START_ENTITY inhibited|nsubjpass|activation inhibited|nmod|END_ENTITY	Insulin-induced Akt activation is inhibited by angiotensin_II in the vasculature through protein_kinase_C-alpha .
25986942	0	Akt	70,73	sex_determining_region_Y-box_2	91,121	Akt	sex determining region Y-box 2	24185(Tax:10116)	499593(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	In oesophageal squamous cells , nitric_oxide causes S-nitrosylation of Akt and blocks SOX2 -LRB- sex_determining_region_Y-box_2 -RRB- expression .
21028992	0	Akt	0,3	sox2	14,18	Akt	sox2	207	6657	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Akt increases sox2 expression in adult hippocampal neural progenitor cells , but increased sox2 does not promote proliferation .
16870179	0	Akt	89,92	toll-like_receptor-9	14,34	Akt	toll-like receptor-9	207	54106	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of toll-like_receptor-9 induces matrix_metalloproteinase-9 expression through Akt and tumor_necrosis_factor-alpha signaling .
24981175	0	Akt	0,3	transketolase	38,51	Akt	transketolase	207	7086	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Akt phosphorylation and regulation of transketolase is a nodal point for amino_acid control of purine synthesis .
18227124	0	Akt	127,130	vascular_cell_adhesion_molecule-1	75,108	Akt	vascular cell adhesion molecule-1	207	7412	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Tumor_necrosis_factor-alpha enhances neutrophil adhesiveness : induction of vascular_cell_adhesion_molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone_deacetylase_4 in human tracheal smooth muscle cells .
10347193	0	Akt	0,3	vascular_endothelial_growth_factor	52,86	Akt	vascular endothelial growth factor	207	7422	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Akt mediates cytoprotection of endothelial cells by vascular_endothelial_growth_factor in an anchorage-dependent manner .
17008323	0	Akt	144,147	vascular_endothelial_growth_factor	24,58	Akt	vascular endothelial growth factor	207	7422	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Ginsenoside-Rg1 induces vascular_endothelial_growth_factor expression through the glucocorticoid_receptor-related phosphatidylinositol_3-kinase / Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells .
17203218	0	Akt	133,136	vascular_endothelial_growth_factor	138,172	Akt	vascular endothelial growth factor	207	22339(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	S-1 inhibits tumorigenicity and angiogenesis of human oral_squamous_cell_carcinoma cells by suppressing expression of phosphorylated Akt , vascular_endothelial_growth_factor and fibroblast_growth_factor-2 .
17483438	0	Akt	65,68	vascular_endothelial_growth_factor	27,61	Akt	vascular endothelial growth factor	207	7422	Gene	Gene	inhibitors|compound|START_ENTITY regulation|nmod|inhibitors regulation|nmod|END_ENTITY	Differential regulation of vascular_endothelial_growth_factor by Akt and mammalian_target_of_rapamycin inhibitors in cell lines derived from childhood solid_tumors .
17572661	0	Akt	0,3	zyxin	23,28	Akt	zyxin	207	7791	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation .
16114056	0	Akt-1	33,38	CXCL12	131,137	Akt-1	CXCL12	207	6387	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate_cancer cells : the role of bone microenvironment-associated CXCL12 .
15452053	0	Akt-1	66,71	HGF	0,3	Akt-1	HGF	207	3082	Gene	Gene	apoptosis|nmod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	HGF protects corneal epithelial cells from apoptosis by the PI-3K / Akt-1 / Bad - but not the ERK1/2-mediated signaling pathway .
15452053	0	Akt-1	66,71	PI-3K	60,65	Akt-1	PI-3K	207	5293	Gene	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	HGF protects corneal epithelial cells from apoptosis by the PI-3K / Akt-1 / Bad - but not the ERK1/2-mediated signaling pathway .
18243508	0	Akt-1	135,140	epidermal_growth_factor_receptor	88,120	Akt-1	epidermal growth factor receptor	207	1956	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Von_Hippel-Lindau tumor suppressor gene loss in renal_cell_carcinoma promotes oncogenic epidermal_growth_factor_receptor signaling via Akt-1 and MEK-1 .
17712528	0	Akt/PKB	91,98	PRPK	82,86	Akt/PKB	PRPK	207	112858	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation and activation of the atypical kinase p53-related_protein_kinase -LRB- PRPK -RRB- by Akt/PKB .
9931326	0	Akt/PKB	59,66	PTEN	0,4	Akt/PKB	PTEN	207	5728	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|END_ENTITY	PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological_malignancies .
19270694	0	Akt/PKB	97,104	Skp2	89,93	Akt/PKB	Skp2	207	6502	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB .
17712528	0	Akt/PKB	91,98	p53-related_protein_kinase	54,80	Akt/PKB	p53-related protein kinase	207	112858	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of the atypical kinase p53-related_protein_kinase -LRB- PRPK -RRB- by Akt/PKB .
11087733	0	Akt1	50,54	3-phosphoinositide-dependent_protein_kinase_1	0,45	Akt1	3-phosphoinositide-dependent protein kinase 1	100769460	100774056	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|appos|kinase	3-phosphoinositide-dependent_protein_kinase_1 , an Akt1 kinase , is involved in dephosphorylation of Thr-308 of Akt1 in Chinese_hamster ovary cells .
25862630	0	Akt1	51,55	ACHN	97,101	Akt1	ACHN	207	55323	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Enhanced sensitivity to sorafenib by inhibition of Akt1 expression in human renal_cell_carcinoma ACHN cells both in vitro and in vivo .
23499911	0	Akt1	109,113	AURKA	126,131	Akt1	AURKA	207	6790	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|activation activation|compound|END_ENTITY	AEG-1 overexpression is essential for maintenance of malignant state in human AML cells via up-regulation of Akt1 mediated by AURKA activation .
17276404	0	Akt1	35,39	CREB	27,31	Akt1	CREB	207	1385	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Differential activation of CREB by Akt1 and Akt2 .
22885182	0	Akt1	0,4	Dlx3	58,62	Akt1	Dlx3	207	1747	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Akt1 regulates phosphorylation and osteogenic activity of Dlx3 .
22227366	0	Akt1	94,98	Fibroblast_growth_factor-2	0,26	Akt1	Fibroblast growth factor-2	207	2247	Gene	Gene	pathway|amod|START_ENTITY promotes|nmod|pathway promotes|nsubj|END_ENTITY	Fibroblast_growth_factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway .
10400647	0	Akt1	70,74	GLUT1	14,19	Akt1	GLUT1	11651(Tax:10090)	20525(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1 .
24516643	0	Akt1	91,95	GRP78	51,56	Akt1	GRP78	207	3309	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
12783873	0	Akt1	35,39	JNK-interacting_protein_1	0,25	Akt1	JNK-interacting protein 1	207	9479	Gene	Gene	activation|amod|START_ENTITY promotes|dobj|activation promotes|nsubj|END_ENTITY	JNK-interacting_protein_1 promotes Akt1 activation .
15797868	0	Akt1	165,169	JNK1/2	115,121	Akt1	JNK1/2	207	5599;5601	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of preconditioning ischemia on ischemic_brain_injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation .
25748236	0	Akt1	22,26	KRas	43,47	Akt1	KRas	11651(Tax:10090)	16653(Tax:10090)	Gene	Gene	Cooperates|nsubj|START_ENTITY Cooperates|nmod|END_ENTITY	Constitutively Active Akt1 Cooperates with KRas -LRB- G12D -RRB- to Accelerate In Vivo Pancreatic_Tumor Onset and Progression .
21658387	0	Akt1	30,34	LRRK2	0,5	Akt1	LRRK2	207	120892	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	LRRK2 directly phosphorylates Akt1 as a possible physiological substrate : impairment of the kinase activity by Parkinson 's _ disease-associated mutations .
16982679	0	Akt1	59,63	MDM2	0,4	Akt1	MDM2	11651(Tax:10090)	17246(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells .
19570880	0	Akt1	0,4	NOS3	35,39	Akt1	NOS3	11651(Tax:10090)	18127(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs .
25996556	0	Akt1	0,4	Nicastrin	20,29	Akt1	Nicastrin	207	23385	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt1 phosphorylates Nicastrin to regulate its protein stability and activity .
25917740	0	Akt1	51,55	PC3	113,116	Akt1	PC3	207	5122	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Enhanced Sensitivity to Sunitinib by Inhibition of Akt1 Expression in Human Castration-resistant Prostate Cancer PC3 Cells Both In Vitro and In Vivo .
25917740	0	Akt1	51,55	PC3	113,116	Akt1	PC3	207	5122	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Enhanced Sensitivity to Sunitinib by Inhibition of Akt1 Expression in Human Castration-resistant Prostate Cancer PC3 Cells Both In Vitro and In Vivo .
24516643	0	Akt1	91,95	PDK1	99,103	Akt1	PDK1	207	5163	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nmod|END_ENTITY	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
20530873	0	Akt1	17,21	PINCH1	0,6	Akt1	PINCH1	207	3987	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha .
12419217	0	Akt1	83,87	PPARbeta	22,30	Akt1	PPARbeta	207	5467	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway .
21592956	0	Akt1	102,106	Protein_Kinase_B	37,53	Akt1	Protein Kinase B	207	2185	Gene	Gene	activity|amod|START_ENTITY required|nmod|activity Serine|ccomp|required Serine|nsubj|Akt Akt|appos|END_ENTITY	mTORC2 protein complex-mediated Akt -LRB- Protein_Kinase_B -RRB- Serine 473 Phosphorylation is not required for Akt1 activity in human platelets -LSB- corrected -RSB- .
23200933	0	Akt1	17,21	Protein_kinase_B	0,16	Akt1	Protein kinase B	207	2185	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	Protein_kinase_B / Akt1 inhibits autophagy by down-regulating UVRAG expression .
12783884	0	Akt1	23,27	Protein_kinase_B_alpha	0,22	Akt1	Protein kinase B alpha	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Protein_kinase_B_alpha / Akt1 regulates placental development and fetal growth .
21443457	0	Akt1	54,58	Wnt1	35,39	Akt1	Wnt1	207	7471	Gene	Gene	requires|dobj|START_ENTITY END_ENTITY|acl:relcl|requires	EPO relies upon novel signaling of Wnt1 that requires Akt1 , FoxO3a , GSK-3b , and b-catenin to foster vascular integrity during experimental diabetes .
17462862	0	Akt1	55,59	caspase-3	30,39	Akt1	caspase-3	207	836	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin .
26579576	0	Akt1	0,4	focal_adhesion_kinase	11,32	Akt1	focal adhesion kinase	207	5747	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Akt1 binds focal_adhesion_kinase via the Akt1 kinase domain independently of the pleckstrin homology domain .
26579576	0	Akt1	41,45	focal_adhesion_kinase	11,32	Akt1	focal adhesion kinase	207	5747	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Akt1 binds focal_adhesion_kinase via the Akt1 kinase domain independently of the pleckstrin homology domain .
21592956	0	Akt1	102,106	mTORC2	0,6	Akt1	mTORC2	207	74343(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY required|nmod|activity Serine|ccomp|required Serine|nsubj|Akt Akt|amod|END_ENTITY	mTORC2 protein complex-mediated Akt -LRB- Protein_Kinase_B -RRB- Serine 473 Phosphorylation is not required for Akt1 activity in human platelets -LSB- corrected -RSB- .
24949720	0	Akt1	26,30	mTORC2	0,6	Akt1	mTORC2	24185(Tax:10116)	74343(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	mTORC2 phosphorylation of Akt1 : a possible mechanism for hydrogen_sulfide-induced cardioprotection .
15857405	0	Akt1	151,155	mixed-lineage_kinase_3	101,123	Akt1	mixed-lineage kinase 3	24185(Tax:10116)	309168(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of preconditioning ischaemia on ischaemic_brain_injury through inhibition of mixed-lineage_kinase_3 via NMDA receptor-mediated Akt1 activation .
11861503	0	Akt1	0,4	muscle_creatine_kinase	35,57	Akt1	muscle creatine kinase	207	1158	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	Akt1 and Akt2 differently regulate muscle_creatine_kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts .
16780593	0	Akt1	0,4	p27kip1	33,40	Akt1	p27kip1	207	1027	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region .
24469394	0	Akt1	50,54	phosphatidylinositol_3-kinase	20,49	Akt1	phosphatidylinositol 3-kinase	207	5290	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Stat5 regulates the phosphatidylinositol_3-kinase / Akt1 pathway during mammary gland development and tumorigenesis .
20153226	0	Akt1	71,75	protein_kinase_B-alpha	47,69	Akt1	protein kinase B-alpha	207	207	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	A comprehensive structure-activity analysis of protein_kinase_B-alpha -LRB- Akt1 -RRB- inhibitors .
21982711	0	Akt2	65,69	FoxA2	111,116	Akt2	FoxA2	208	3170	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2 , FoxO1 , and SREBP1c .
10523666	0	Akt2	32,36	GLUT4	59,64	Akt2	GLUT4	25233(Tax:10116)	25139(Tax:10116)	Gene	Gene	START_ENTITY|nmod|translocation translocation|compound|END_ENTITY	A role for protein_kinase_Bbeta / Akt2 in insulin-stimulated GLUT4 translocation in adipocytes .
22044669	0	Akt2	33,37	PHLPP1	16,22	Akt2	PHLPP1	208	23239	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The phosphatase PHLPP1 regulates Akt2 , promotes pancreatic_cancer cell death , and inhibits tumor formation .
11087731	0	Akt2	22,26	Protein_kinase_B_beta	0,21	Akt2	Protein kinase B beta	208	208	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	Protein_kinase_B_beta / Akt2 plays a specific role in muscle differentiation .
21743498	0	Akt2	11,15	Pten	49,53	Akt2	Pten	11652(Tax:10090)	19211(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	The effect Akt2 deletion on tumor development in Pten -LRB- + / - -RRB- mice .
23499910	0	Akt2	0,4	Rac1	15,19	Akt2	Rac1	208	5879	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells .
20079400	0	Akt2	16,20	Smad5	0,5	Akt2	Smad5	25233(Tax:10116)	59328(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes .
22158034	0	Akt2	0,4	Snail1	20,26	Akt2	Snail1	208	6615	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Akt2 interacts with Snail1 in the E-cadherin promoter .
15753124	0	Akt2	0,4	Synip	20,25	Akt2	Synip	208	252983	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles .
16982699	0	Akt2	47,51	p21	85,88	Akt2	p21	208	1026	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Only Akt1 is required for proliferation , while Akt2 promotes cell cycle exit through p21 binding .
21050850	0	Akt2	0,4	palladin	56,64	Akt2	palladin	208	27143	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Akt2 regulates expression of the actin-bundling protein palladin .
10523666	0	Akt2	32,36	protein_kinase_Bbeta	11,31	Akt2	protein kinase Bbeta	25233(Tax:10116)	25233(Tax:10116)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for protein_kinase_Bbeta / Akt2 in insulin-stimulated GLUT4 translocation in adipocytes .
24686007	0	Akt3	82,86	MiR-489	0,7	Akt3	MiR-489	10000	574442	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	MiR-489 modulates cisplatin resistance in human ovarian_cancer cells by targeting Akt3 .
24942865	0	Akt3	100,104	insulin-like_growth_factor_binding_protein-3	52,96	Akt3	insulin-like growth factor binding protein-3	10000	3486	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional and posttranslational regulation of insulin-like_growth_factor_binding_protein-3 by Akt3 .
21351097	0	Akt3	0,4	vascular_endothelial_growth_factor	14,48	Akt3	vascular endothelial growth factor	10000	7422	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|secretion secretion|compound|END_ENTITY	Akt3 controls vascular_endothelial_growth_factor secretion and angiogenesis in ovarian_cancer cells .
26294214	0	Akt_Kinase-Interacting_Protein_1	0,32	CREB	49,53	Akt Kinase-Interacting Protein 1	CREB	54862	1385	Gene	Gene	Signals|nsubj|START_ENTITY Signals|nmod|END_ENTITY	Akt_Kinase-Interacting_Protein_1 Signals through CREB to Drive Diffuse_Malignant_Mesothelioma .
15580267	0	Akt_and_14-3-3eta	0,17	Miz1	27,31	Akt and 14-3-3eta	Miz1	207;7533	7709	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Akt_and_14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage .
7736780	0	AlK	70,73	anaplastic_lymphoma_kinase	42,68	AlK	anaplastic lymphoma kinase	11682(Tax:10090)	11682(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the murine homolog of the anaplastic_lymphoma_kinase -LRB- AlK -RRB- gene on mouse chromosome 17 .
16899523	0	AlaAT	46,51	alanine_aminotransferase	20,44	AlaAT	alanine aminotransferase	11444017	11444017	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of alanine_aminotransferase -LRB- AlaAT -RRB- multigene family and hypoxic response in young seedlings of the model legume Medicago_truncatula .
26444490	0	Alanine-Serine-Cysteine_Transporter	25,60	ASCT2	62,67	Alanine-Serine-Cysteine Transporter	ASCT2	6510	6510	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Ligand Discovery for the Alanine-Serine-Cysteine_Transporter -LRB- ASCT2 , SLC1A5 -RRB- from Homology Modeling and Virtual Screening .
11935028	0	Alba	19,23	Sir2	70,74	Alba	Sir2	173	23411	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of Alba , a conserved archaeal chromatin protein , with Sir2 and its regulation by acetylation .
26182958	0	Albumin	57,64	C-Reactive_Protein	77,95	Albumin	C-Reactive Protein	213	1401	Gene	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Relationship of Neutrophil-to-Lymphocyte Ratio and Serum Albumin Levels with C-Reactive_Protein in Hemodialysis Patients : Results from 2 International Cohort Studies .
26390126	0	Albumin	68,75	C-Reactive_Protein	49,67	Albumin	C-Reactive Protein	213	1401	Gene	Gene	Ratio|compound|START_ENTITY Ratio|dep|END_ENTITY	A Novel Inflammation-Based Prognostic Score , the C-Reactive_Protein / Albumin Ratio Predicts the Prognosis of Patients with Operable Esophageal_Squamous_Cell_Carcinoma .
26390126	0	Albumin	68,75	C-Reactive_Protein	49,67	Albumin	C-Reactive Protein	213	1401	Gene	Gene	Ratio|compound|START_ENTITY Ratio|dep|END_ENTITY	A Novel Inflammation-Based Prognostic Score , the C-Reactive_Protein / Albumin Ratio Predicts the Prognosis of Patients with Operable Esophageal_Squamous_Cell_Carcinoma .
1895489	0	Albumin	71,78	albumin	12,19	Albumin	albumin	213	213	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of albumin in human physiology and pathophysiology , Part III : Albumin and disease states .
12815038	0	Albumin	0,7	chymase	32,39	Albumin	chymase	213	1215	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Albumin is a substrate of human chymase .
19034873	0	Albumin	0,7	interleukin-6	16,29	Albumin	interleukin-6	213	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells .
12588890	0	Albumin	0,7	interleukin-8	19,32	Albumin	interleukin-8	213	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo .
15880558	0	Albumin	0,7	monocyte_chemotactic_protein-1	19,49	Albumin	monocyte chemotactic protein-1	24186(Tax:10116)	24770(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Albumin stimulates monocyte_chemotactic_protein-1 expression in rat embryonic mixed brain cells .
21073867	0	Alcama	0,6	Edn1	16,20	Alcama	Edn1	30194(Tax:7955)	58032(Tax:7955)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis .
26379912	0	Alcohol_dehydrogenase_1C	0,24	ADH1C	26,31	Alcohol dehydrogenase 1C	ADH1C	126	126	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alcohol_dehydrogenase_1C -LRB- ADH1C -RRB- gene polymorphism and alcoholic_liver_cirrhosis risk : a meta analysis .
8353517	0	Aldehyde_dehydrogenase	0,22	ALDH	24,28	Aldehyde dehydrogenase	ALDH	34256(Tax:7227)	34256(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Aldehyde_dehydrogenase -LRB- ALDH -RRB- activity in Drosophila_melanogaster adults : evidence for cytosolic localization .
15639999	0	Aldehyde_dehydrogenase	1,23	ALDH2	25,30	Aldehyde dehydrogenase	ALDH2	217	217	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	-LSB- Aldehyde_dehydrogenase -LRB- ALDH2 -RRB- polymorphism and drinking behavior -RSB- .
25843691	0	Aldehyde_dehydrogenase_1	0,24	ALDH1	26,31	Aldehyde dehydrogenase 1	ALDH1	216	216	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Aldehyde_dehydrogenase_1 -LRB- ALDH1 -RRB- expression is associated with a poor prognosis of bladder_cancer .
26896768	0	Aldehyde_dehydrogenase_1A1	0,26	Gli2	59,63	Aldehyde dehydrogenase 1A1	Gli2	216	2736	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Aldehyde_dehydrogenase_1A1 stabilizes transcription factor Gli2 and enhances the activity of Hedgehog signaling in hepatocellular_cancer .
26379870	0	Aldehyde_dehydrogenase_2	0,24	ALDH2	26,31	Aldehyde dehydrogenase 2	ALDH2	217	217	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- Glu504Lys polymorphism is associated with hypertension risk in Asians : a meta-analysis .
9819390	0	Aldh1	45,50	HOX11	29,34	Aldh1	HOX11	11668(Tax:10090)	15404(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development .
19651241	0	Aldh1A2	128,135	aldehyde_dehydrogenase_1A2	100,126	Aldh1A2	aldehyde dehydrogenase 1A2	100049450(Tax:8090)	100049450(Tax:8090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Ethanol disrupts chondrification of the neurocranial cartilages in medaka embryos without affecting aldehyde_dehydrogenase_1A2 -LRB- Aldh1A2 -RRB- promoter methylation .
17567582	0	Aldh1a1	119,126	Aldh3a1	106,113	Aldh1a1	Aldh3a1	11668(Tax:10090)	11670(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Multiple and additive functions of ALDH3A1 and ALDH1A1 : cataract phenotype and ocular oxidative damage in Aldh3a1 -LRB- - / - -RRB- / Aldh1a1 -LRB- - / - -RRB- knock-out mice .
23553814	0	Aldh1a2	17,24	HOXA13	0,6	Aldh1a2	HOXA13	19378(Tax:10090)	15398(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death .
15900217	0	Aldh2	64,69	mitochondrial_aldehyde_dehydrogenase	21,57	Aldh2	mitochondrial aldehyde dehydrogenase	29539(Tax:10116)	29539(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the mitochondrial_aldehyde_dehydrogenase gene -LRB- Aldh2 -RRB- determine peak blood acetaldehyde levels and voluntary_ethanol_consumption in rats .
17567582	0	Aldh3a1	106,113	Aldh1a1	119,126	Aldh3a1	Aldh1a1	11670(Tax:10090)	11668(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Multiple and additive functions of ALDH3A1 and ALDH1A1 : cataract phenotype and ocular oxidative damage in Aldh3a1 -LRB- - / - -RRB- / Aldh1a1 -LRB- - / - -RRB- knock-out mice .
21642744	0	Aldo-keto_reductase_1B7	0,23	FXR	44,47	Aldo-keto reductase 1B7	FXR	11997(Tax:10090)	20186(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Aldo-keto_reductase_1B7 is a target gene of FXR and regulates lipid and glucose homeostasis .
26376879	0	Aldolase_B	0,10	Ten-Eleven_Translocation_1	39,65	Aldolase B	Ten-Eleven Translocation 1	229	80312	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Aldolase_B inhibits metastasis through Ten-Eleven_Translocation_1 and serves as a prognostic biomarker in hepatocellular_carcinoma .
21468188	0	Aldosterone_Synthase	0,20	CYP11B2	27,34	Aldosterone Synthase	CYP11B2	1585	1585	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Aldosterone_Synthase Gene -LRB- CYP11B2 -RRB- Polymorphism in Korean End-Stage Renal_Disease Patients on Hemodialysis .
25957425	0	Aldosterone_Synthase	0,20	CYP11B2	21,28	Aldosterone Synthase	CYP11B2	1585	1585	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Aldosterone_Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic_Kidney_Disease .
26403853	0	Aldosterone_Synthase	92,112	CYP11B2	114,121	Aldosterone Synthase	CYP11B2	24294(Tax:10116)	24294(Tax:10116)	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Discovery of 4-Aryl-5 ,6,7,8 - tetrahydroisoquinolines as Potent , Selective , and Orally Active Aldosterone_Synthase -LRB- CYP11B2 -RRB- Inhibitors : In Vivo Evaluation in Rodents and Cynomolgus_Monkeys .
10608469	0	Aldosterone_synthase	0,20	CYP11B2	27,34	Aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-344T polymorphism in Caucasians from the Berlin Salt-Sensitivity Trial -LRB- BeSST -RRB- .
11693765	0	Aldosterone_synthase	0,20	CYP11B2	22,29	Aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Aldosterone_synthase -LRB- CYP11B2 -RRB- -344 _ C/T polymorphism is associated with left ventricular structure in human arterial hypertension .
11725161	0	Aldosterone_synthase	0,20	CYP11B2	27,34	Aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-334T polymorphism , ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population : the Ohasama Study .
15361760	0	Aldosterone_synthase	0,20	CYP11B2	27,34	Aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-344T polymorphism , plasma aldosterone , renin activity and blood pressure in a multi-ethnic population .
16759311	0	Aldosterone_synthase	0,20	CYP11B2	22,29	Aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Aldosterone_synthase -LRB- CYP11B2 -RRB- -344 T/C polymorphism is not associated with the initiation and progression of diabetic_nephropathy in Caucasian Type 1 diabetic patients .
20176774	0	Aldosterone_synthase	0,20	CYP11B2	27,34	Aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- promoter polymorphism as a risk factor for ischaemic_stroke in Tunisian Arabs .
25385288	0	Alfy	31,35	Autophagy-linked_FYVE	0,21	Alfy	Autophagy-linked FYVE	72145(Tax:10090)	72145(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Autophagy-linked_FYVE protein -LRB- Alfy -RRB- promotes autophagic removal of misfolded proteins involved in amyotrophic_lateral_sclerosis -LRB- ALS -RRB- .
16100110	0	Alg13	15,20	Alg14	0,5	Alg13	Alg14	852835(Tax:4932)	852362(Tax:4932)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation .
16100110	0	Alg14	0,5	Alg13	15,20	Alg14	Alg13	852362(Tax:4932)	852835(Tax:4932)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation .
17570542	0	Alien	0,5	E2F1	15,19	Alien	E2F1	9318	1869	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Alien inhibits E2F1 gene expression and cell proliferation .
17356171	0	Alien	0,5	androgen_receptor	31,48	Alien	androgen receptor	9318	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Alien interacts with the human androgen_receptor and inhibits_prostate_cancer cell growth .
18940611	0	Alix	56,60	ALG-2	50,55	Alix	ALG-2	10015	85365	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Structural basis for Ca2 + - dependent formation of ALG-2 / Alix peptide complex : Ca2 + / EF3-driven arginine switch mechanism .
25597757	0	Alix	38,42	Interleukin-13	0,14	Alix	Interleukin-13	18571(Tax:10090)	16163(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Interleukin-13 promotes expression of Alix to compromise renal tubular epithelial barrier function .
20519395	0	Alix	29,33	Nedd4-1	64,71	Alix	Nedd4-1	10015	4734	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif .
25118280	0	Alix	55,59	Nef	21,24	Alix	Nef	10015	156110(Tax:11676)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor .
21976498	0	Alk	0,3	LMO4	35,39	Alk	LMO4	11682(Tax:10090)	16911(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Alk is a transcriptional target of LMO4 and ERa that promotes cocaine sensitization and reward .
23863480	0	Alk1	43,47	Bmp10	12,17	Alk1	Bmp10	266753(Tax:7955)	562533(Tax:7955)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence .
22799562	0	Alk1	17,21	bone_morphogenetic_protein	71,97	Alk1	bone morphogenetic protein	94	649	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Structure of the Alk1 extracellular domain and characterization of its bone_morphogenetic_protein -LRB- BMP -RRB- binding properties .
11117535	0	Alk4	34,38	activin	10,17	Alk4	activin	91	83729	Gene	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling .
21285982	0	AlkB	16,20	ALKBH3	0,6	AlkB	ALKBH3	8846	221120	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	ALKBH3 , a human AlkB homologue , contributes to cell survival in human non-small-cell lung_cancer .
22065580	0	AlkB	84,88	AlkB_homolog_8	106,120	AlkB	AlkB homolog 8	8846	91801	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Crystal structure and RNA binding properties of the RNA recognition motif -LRB- RRM -RRB- and AlkB domains in human AlkB_homolog_8 -LRB- ABH8 -RRB- , an enzyme catalyzing tRNA hypermodification .
22065580	0	AlkB_homolog_8	106,120	AlkB	84,88	AlkB homolog 8	AlkB	91801	8846	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	Crystal structure and RNA binding properties of the RNA recognition motif -LRB- RRM -RRB- and AlkB domains in human AlkB_homolog_8 -LRB- ABH8 -RRB- , an enzyme catalyzing tRNA hypermodification .
23290262	0	Alkyladenine_DNA_glycosylase	0,28	mitochondrial_single-stranded_binding_protein	80,125	Alkyladenine DNA glycosylase	mitochondrial single-stranded binding protein	4350	6742	Gene	Gene	localizes|nsubj|START_ENTITY localizes|nmod|END_ENTITY	Alkyladenine_DNA_glycosylase -LRB- AAG -RRB- localizes to mitochondria and interacts with mitochondrial_single-stranded_binding_protein -LRB- mtSSB -RRB- .
19555433	0	Alox12	35,41	p63	0,3	Alox12	p63	239	8626	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	p63 directly induces expression of Alox12 , a regulator of epidermal barrier formation .
20967760	0	Alox15	43,49	12/15-lipoxygenase	18,36	Alox15	12/15-lipoxygenase	11687(Tax:10090)	11687(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disruption of the 12/15-lipoxygenase gene -LRB- Alox15 -RRB- protects hyperlipidemic mice from nonalcoholic fatty liver_disease .
20109307	0	Alpha-1-Antitrypsin	31,50	SERPINA1	21,29	Alpha-1-Antitrypsin	SERPINA1	5265	5265	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the SERPINA1 -LRB- Alpha-1-Antitrypsin -RRB- gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy .
16137793	0	Alpha-1-antichymotrypsin	0,24	ACT	26,29	Alpha-1-antichymotrypsin	ACT	12	12	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Alpha-1-antichymotrypsin -LRB- ACT or SERPINA3 -RRB- polymorphism may affect age-at-onset and disease duration of Alzheimer 's _ disease .
2379100	0	Alpha-1-antitrypsin	0,19	alpha-1-antitrypsin	80,99	Alpha-1-antitrypsin	alpha-1-antitrypsin	5265	5265	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Alpha-1-antitrypsin in the renal tubular epithelium in patients with or without alpha-1-antitrypsin deficiency .
2482548	0	Alpha-2-macroglobulin	0,21	thrombin	63,71	Alpha-2-macroglobulin	thrombin	2	2147	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Alpha-2-macroglobulin is an important progressive inhibitor of thrombin in neonatal and infant plasma .
25545207	0	Alpha-Chain	62,73	T_Cell_Antigen_Receptor	38,61	Alpha-Chain	T Cell Antigen Receptor	2217	6962	Gene	Gene	Antibody|compound|START_ENTITY Antibody|compound|END_ENTITY	Detection of Constant Domain of Human T_Cell_Antigen_Receptor Alpha-Chain Via Novel Monoclonal Antibody 7F18 .
19075109	0	Alpha-E-catenin	0,15	dynamitin	25,34	Alpha-E-catenin	dynamitin	1495	10540	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic .
17014957	0	Alpha-MSH	0,9	IL-1beta	86,94	Alpha-MSH	IL-1beta	5443	3553	Gene	Gene	modulate|nsubj|START_ENTITY modulate|nmod|END_ENTITY	Alpha-MSH and gamma-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1beta differently .
9763304	0	Alpha-MSH	0,9	interleukin-10	20,34	Alpha-MSH	interleukin-10	5443	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Alpha-MSH regulates interleukin-10 expression by human keratinocytes .
1328399	0	Alpha-MSH	0,9	tyrosinase	71,81	Alpha-MSH	tyrosinase	18976(Tax:10090)	22173(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	Alpha-MSH and other melanogenic activators mediate opposite effects on tyrosinase and dopachrome_tautomerase in B16/F10 mouse melanoma cells .
19187332	0	Alpha-T-catenin	0,15	CTNNA3	17,23	Alpha-T-catenin	CTNNA3	29119	29119	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alpha-T-catenin -LRB- CTNNA3 -RRB- gene was identified as a risk variant for toluene_diisocyanate-induced asthma by genome-wide association analysis .
7543018	0	Alpha-fetoprotein	0,17	AFP	19,22	Alpha-fetoprotein	AFP	24177(Tax:10116)	24177(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Alpha-fetoprotein -LRB- AFP -RRB- expression in clones of McA-RH 7777 rat hepatoma : correlation with the occurrence of homogeneously staining regions on chromosome 14 .
11314020	0	Alpha-fetoprotein	0,17	ATBF1	70,75	Alpha-fetoprotein	ATBF1	174	463	Gene	Gene	gastric_cancer|amod|START_ENTITY lacks|nsubj|gastric_cancer lacks|dobj|END_ENTITY	Alpha-fetoprotein producing gastric_cancer lacks transcription factor ATBF1 .
26176088	0	Alpha-fetoprotein	103,120	Carcinoembryonic_Antigen	69,93	Alpha-fetoprotein	Carcinoembryonic Antigen	174	1084	Gene	Gene	CA72-4|appos|START_ENTITY CA72-4|compound|END_ENTITY	Prognostic Value of Preoperative Serum Levels of Five Tumor Markers -LRB- Carcinoembryonic_Antigen , CA19-9 , Alpha-fetoprotein , CA72-4 , and CA125 -RRB- in Gastric_Cancer .
8989923	0	Alpha-fetoprotein	0,17	TNF	23,26	Alpha-fetoprotein	TNF	174	7124	Gene	Gene	START_ENTITY|nmod|factor factor|compound|END_ENTITY	Alpha-fetoprotein as a TNF resistance factor for the human hepatocarcinoma cell line HepG2 .
21793627	0	Alpha-fetoprotein	0,17	carcinoembryonic_antigen	19,43	Alpha-fetoprotein	carcinoembryonic antigen	174	1084	Gene	Gene	population|amod|START_ENTITY population|amod|END_ENTITY	Alpha-fetoprotein , carcinoembryonic_antigen and beta2-microglobulin in adult population highly exposed to organochlorinated pollutants -LRB- PCB , DDE and HCB -RRB- .
19184104	0	Alpha-fetoprotein	0,17	telomerase_reverse_transcriptase	28,60	Alpha-fetoprotein	telomerase reverse transcriptase	174	7015	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Alpha-fetoprotein and human telomerase_reverse_transcriptase mRNA levels in peripheral blood of patients with hepatocellular_carcinoma .
8264864	0	Alpha-melanocyte-stimulating_hormone	0,36	IL-1	47,51	Alpha-melanocyte-stimulating hormone	IL-1	5443	3552	Gene	Gene	abolishes|nsubj|START_ENTITY abolishes|dobj|release release|amod|END_ENTITY	Alpha-melanocyte-stimulating_hormone abolishes IL-1 - and IL-6-induced corticotropin-releasing_factor release from the hypothalamus in vitro .
7489328	0	Alpha-melanocyte-stimulating_hormone	0,36	corticotropin-releasing_factor	46,76	Alpha-melanocyte-stimulating hormone	corticotropin-releasing factor	5443	1392	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Alpha-melanocyte-stimulating_hormone inhibits corticotropin-releasing_factor release by blocking protein kinase C. Cytokine-induced release of corticotropin-releasing_factor -LRB- CRF -RRB- from hypothalamic explants in vitro can be inhibited by femtomolar concentrations of alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- .
8264864	0	Alpha-melanocyte-stimulating_hormone	0,36	corticotropin-releasing_factor	70,100	Alpha-melanocyte-stimulating hormone	corticotropin-releasing factor	5443	1392	Gene	Gene	abolishes|nsubj|START_ENTITY abolishes|dobj|release release|amod|END_ENTITY	Alpha-melanocyte-stimulating_hormone abolishes IL-1 - and IL-6-induced corticotropin-releasing_factor release from the hypothalamus in vitro .
8045978	0	Alpha-melanocyte-stimulating_hormone	0,36	corticotropin-releasing_hormone	74,105	Alpha-melanocyte-stimulating hormone	corticotropin-releasing hormone	5443	1392	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|effect effect|nmod|END_ENTITY	Alpha-melanocyte-stimulating_hormone antagonizes the inhibitory effect of corticotropin-releasing_hormone on luteinizing hormone secretion during the luteal phase in normal women .
8412510	0	Alpha-melanocyte_stimulating_hormone	0,36	corticotropin_releasing_factor	71,101	Alpha-melanocyte stimulating hormone	corticotropin releasing factor	24664(Tax:10116)	81648(Tax:10116)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Alpha-melanocyte_stimulating_hormone -LRB- MSH -RRB- antagonizes the anorexia by corticotropin_releasing_factor -LRB- CRF -RRB- .
17052748	0	Alpha-melanocyte_stimulating_hormone	0,36	neuropeptide_Y	79,93	Alpha-melanocyte stimulating hormone	neuropeptide Y	24664(Tax:10116)	24604(Tax:10116)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|effect effect|nmod|END_ENTITY	Alpha-melanocyte_stimulating_hormone antagonizes antidepressant-like effect of neuropeptide_Y in Porsolt 's test in rats .
15602744	0	Alpha-methylacyl-CoA_racemase	0,29	AMACR	31,36	Alpha-methylacyl-CoA racemase	AMACR	23600	23600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Alpha-methylacyl-CoA_racemase -LRB- AMACR -RRB- expression in normal prostatic glands and high-grade prostatic_intraepithelial_neoplasia -LRB- HGPIN -RRB- : association with diagnosis of prostate_cancer .
18005096	0	Alpha-smooth_muscle_actin	0,25	transforming_growth_factor-beta_1	143,176	Alpha-smooth muscle actin	transforming growth factor-beta 1	25365(Tax:10116)	59086(Tax:10116)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Alpha-smooth_muscle_actin -LRB- alpha-SMA -RRB- and nestin expression in reactive astrocytes in multiple_sclerosis lesions : potential regulatory role of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- .
17012252	0	Alpha-synuclein	0,15	ICAM-1	55,61	Alpha-synuclein	ICAM-1	6622	3383	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells .
26033182	0	Alpha-synuclein	0,15	Notch1	37,43	Alpha-synuclein	Notch1	6622	4851	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Alpha-synuclein negatively regulates Notch1 intracellular domain protein stability through promoting interaction with Fbw7 .
12928483	0	Alpha-synuclein	0,15	neurosin	47,55	Alpha-synuclein	neurosin	6622	5653	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Alpha-synuclein degradation by serine protease neurosin : implication for pathogenesis of synucleinopathies .
21748932	0	Alpha-synuclein	0,15	tyrosine_hydroxylase	68,88	Alpha-synuclein	tyrosine hydroxylase	6622	7054	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Alpha-synuclein functions as a negative regulator for expression of tyrosine_hydroxylase .
15718509	0	Alpha1-antichymotrypsin	0,23	SERPINA3	30,38	Alpha1-antichymotrypsin	SERPINA3	12	12	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alpha1-antichymotrypsin gene -LRB- SERPINA3 -RRB- A/T polymorphism as a risk factor for aneurysmal_subarachnoid_hemorrhage .
14715656	0	Alpha2-macroglobulin	0,20	ADAMTS-4	46,54	Alpha2-macroglobulin	ADAMTS-4	2	9507	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes .
19818709	0	Alpha4	0,6	PP2A	36,40	Alpha4	PP2A	3476	5524	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	Alpha4 is an essential regulator of PP2A phosphatase activity .
20441791	0	AlphaB-crystallin	0,17	VEGF	75,79	AlphaB-crystallin	VEGF	12955(Tax:10090)	22339(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|protection protection|acl|determined determined|nmod|END_ENTITY	AlphaB-crystallin is involved in oxidative stress protection determined by VEGF in skeletal myoblasts .
17085453	0	AlphaCP1	0,8	growth_hormone	65,79	AlphaCP1	growth hormone	5093	2688	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	AlphaCP1 mediates stabilization of hTERT mRNA by autocrine human growth_hormone .
14599290	0	AlphaII-spectrin	0,16	caspase-2	43,52	AlphaII-spectrin	caspase-2	6709	835	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	AlphaII-spectrin is an in vitro target for caspase-2 , and its cleavage is regulated by calmodulin binding .
15611136	0	AlphaPIX	0,8	calpain_4	25,34	AlphaPIX	calpain 4	9459	826	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	AlphaPIX associates with calpain_4 , the small subunit of calpain , and has a dual role in integrin-mediated cell spreading .
24175110	0	Alpha_1-Antichymotrypsin	0,24	c-Jun_N-Terminal_Kinase	157,180	Alpha 1-Antichymotrypsin	c-Jun N-Terminal Kinase	12	26419(Tax:10090)	Gene	Gene	Induces|nsubj|START_ENTITY Induces|nmod|Activation Activation|amod|END_ENTITY	Alpha_1-Antichymotrypsin , an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer 's _ Disease , Induces Tau Hyperphosphorylation through c-Jun_N-Terminal_Kinase Activation .
25937984	0	Alpha_S1-Casein	39,54	Milk_Protein	55,67	Alpha S1-Casein	Milk Protein	282208(Tax:9913)	281099(Tax:9913)	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Variations in the Regulatory Region of Alpha_S1-Casein Milk_Protein Gene among Tropically Adapted Indian Native -LRB- Bos_Indicus -RRB- Cattle .
23825702	0	Alx3	28,32	BMP-2	0,5	Alx3	BMP-2	11694(Tax:10090)	12156(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation .
11696550	0	Alx4	0,4	LEF-1	16,21	Alx4	LEF-1	11695(Tax:10090)	16842(Tax:10090)	Gene	Gene	binding|advmod|START_ENTITY binding|nmod|END_ENTITY	Alx4 binding to LEF-1 regulates N-CAM promoter activity .
15944083	0	AmDOP3	49,55	D2-like_dopamine_receptor	22,47	AmDOP3	D2-like dopamine receptor	408995(Tax:7460)	408995(Tax:7460)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a D2-like_dopamine_receptor -LRB- AmDOP3 -RRB- in honey_bee , Apis_mellifera .
9126491	0	Ameloblastin	0,12	AMBN	19,23	Ameloblastin	AMBN	258	258	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Ameloblastin gene -LRB- AMBN -RRB- maps within the critical region for autosomal_dominant_amelogenesis_imperfecta at chromosome 4q21 .
22243257	0	Ameloblastin	0,12	RhoA	65,69	Ameloblastin	RhoA	11698(Tax:10090)	11848(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ameloblastin regulates cell attachment and proliferation through RhoA and p27 .
17525271	0	Aminoacyl-tRNA_synthetase-interacting_multifunctional_protein_1	0,63	p43	64,67	Aminoacyl-tRNA synthetase-interacting multifunctional protein 1	p43	13722(Tax:10090)	13722(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	Aminoacyl-tRNA_synthetase-interacting_multifunctional_protein_1 / p43 controls endoplasmic reticulum retention of heat_shock protein gp96 : its pathological implications in lupus-like autoimmune_diseases .
1548181	0	Aminopeptidase	0,14	C-1027	52,58	Aminopeptidase	C-1027	10404	1038631(Tax:199310)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Aminopeptidase activity of an antitumor antibiotic , C-1027 .
18366676	0	Aminopeptidase_N	0,16	CD13	23,27	Aminopeptidase N	CD13	290	290	Gene	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	Aminopeptidase_N -LRB- APN -RRB- / CD13 inhibitor , Ubenimex , enhances radiation sensitivity in human cervical_cancer .
1699290	0	Amog	14,18	adhesion_molecule_on_glia	20,45	Amog	adhesion molecule on glia	11932(Tax:10090)	11932(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of Amog -LRB- adhesion_molecule_on_glia -RRB- gene to mouse chromosome 11 near Zfp-3 and Asgr-1 ,2 and to human chromosome 17 .
23525008	0	Amotl2	0,6	LL5b	22,26	Amotl2	LL5b	51421	90102	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Amotl2 interacts with LL5b , localizes to podosomes and regulates postsynaptic differentiation in muscle .
26335201	0	Amotl2a	0,7	Yap1	42,46	Amotl2a	Yap1	558920(Tax:7955)	561411(Tax:7955)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Amotl2a interacts with the Hippo effector Yap1 and the Wnt/b-catenin effector Lef1 to control tissue size in zebrafish .
25261255	0	Amphiregulin	0,12	E-cadherin	75,85	Amphiregulin	E-cadherin	374	999	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|amod|END_ENTITY	Amphiregulin induces human ovarian_cancer cell invasion by down-regulating E-cadherin expression .
20726858	0	Amphiregulin	0,12	ERK	41,44	Amphiregulin	ERK	374	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Amphiregulin regulates the activation of ERK and Akt through epidermal_growth_factor_receptor and HER3 signals involved in the progression of pancreatic_cancer .
16376136	0	Amphiregulin	0,12	cyclooxygenase_2	82,98	Amphiregulin	cyclooxygenase 2	374	5743	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Amphiregulin as a tumor promoter for oral_squamous_cell_carcinoma : involvement of cyclooxygenase_2 .
20726858	0	Amphiregulin	0,12	epidermal_growth_factor_receptor	61,93	Amphiregulin	epidermal growth factor receptor	374	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signals signals|compound|END_ENTITY	Amphiregulin regulates the activation of ERK and Akt through epidermal_growth_factor_receptor and HER3 signals involved in the progression of pancreatic_cancer .
23333074	0	Amphiregulin	0,12	epidermal_growth_factor_receptor	69,101	Amphiregulin	epidermal growth factor receptor	374	1956	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Amphiregulin enhances regulatory T cell-suppressive function via the epidermal_growth_factor_receptor .
7679104	0	Amphiregulin	0,12	epidermal_growth_factor_receptor	53,85	Amphiregulin	epidermal growth factor receptor	374	1956	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Amphiregulin induces tyrosine phosphorylation of the epidermal_growth_factor_receptor and p185erbB2 .
26503469	0	Amphiregulin	0,12	intercellular_adhesion_molecule-1	22,55	Amphiregulin	intercellular adhesion molecule-1	374	3383	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Amphiregulin enhances intercellular_adhesion_molecule-1 expression and promotes tumor metastasis in human osteosarcoma .
18325497	0	Amphiregulin	0,12	transforming_growth_factor-alpha	52,84	Amphiregulin	transforming growth factor-alpha	374	7124	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Amphiregulin is much more abundantly expressed than transforming_growth_factor-alpha and epidermal_growth_factor in human follicular fluid obtained from patients undergoing in vitro fertilization-embryo transfer .
23926104	0	Amplified_in_Liver_Cancer_1	155,182	ALC1	184,188	Amplified in Liver Cancer 1	ALC1	9557	9557	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Tripartite_Motif-containing_33 -LRB- TRIM33 -RRB- protein functions in the poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- - dependent DNA damage response through interaction with Amplified_in_Liver_Cancer_1 -LRB- ALC1 -RRB- protein .
22213475	0	Amplified_in_breast_cancer_1	0,28	Akt	120,123	Amplified in breast cancer 1	Akt	63897	207	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Amplified_in_breast_cancer_1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways .
12487019	0	Amt	64,67	aminomethyltransferase	35,57	Amt	aminomethyltransferase	434437(Tax:10090)	434437(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the murine aminomethyltransferase gene -LRB- Amt -RRB- .
25750761	0	Amylin	7,13	Insulin	75,82	Amylin	Insulin	3375	3630	Gene	Gene	START_ENTITY|nmod|Treatment Treatment|compound|END_ENTITY	Plasma Amylin and Cognition in Diabetes in the Absence and the Presence of Insulin Treatment .
26655697	0	Amylin	13,19	Leptin	41,47	Amylin	Leptin	15874(Tax:10090)	16846(Tax:10090)	Gene	Gene	Acts|nsubj|START_ENTITY Acts|nmod|Concert Concert|nmod|END_ENTITY	Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake .
7649582	0	Amylin	0,6	renin	25,30	Amylin	renin	3375	5972	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|concentration concentration|compound|END_ENTITY	Amylin stimulates plasma renin concentration in humans .
8779889	0	Amylin	0,6	renin	94,99	Amylin	renin	24476(Tax:10116)	24715(Tax:10116)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Amylin binding in rat renal cortex , stimulation of adenylyl cyclase , and activation of plasma renin .
26053850	0	Amyloid-b_Precursor_Protein	70,97	APP	99,102	Amyloid-b Precursor Protein	APP	351	351	Gene	Gene	Processing|compound|START_ENTITY Processing|appos|END_ENTITY	The Golgi-Localized y-Ear-Containing ARF-Binding -LRB- GGA -RRB- Proteins Alter Amyloid-b_Precursor_Protein -LRB- APP -RRB- Processing through Interaction of Their GAE Domain with the Beta-Site_APP_Cleaving_Enzyme_1 -LRB- BACE1 -RRB- .
26401782	0	Amyloid-b_Protein_Precursor	17,44	Presenilin_1_and_2	59,77	Amyloid-b Protein Precursor	Presenilin 1 and 2	54226(Tax:10116)	29192;81751	Gene	Gene	Genes|amod|START_ENTITY Genes|amod|END_ENTITY	Dysregulation of Amyloid-b_Protein_Precursor , b-Secretase , Presenilin_1_and_2 Genes in the Rat Selectively Vulnerable CA1 Subfield of Hippocampus Following Transient Global_Brain_Ischemia .
26510981	0	Amyloid_Precursor_Protein	116,141	APP	143,146	Amyloid Precursor Protein	APP	351	351	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	The ATP-Binding_Cassette_Transporter-2 -LRB- ABCA2 -RRB- Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid_Precursor_Protein -LRB- APP -RRB- Gene .
7633445	0	Amyloid_Precursor_Protein	49,74	APP	76,79	Amyloid Precursor Protein	APP	351	351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No evidence that common allelic variation in the Amyloid_Precursor_Protein -LRB- APP -RRB- gene confers susceptibility to Alzheimer 's _ disease .
26510981	0	Amyloid_Precursor_Protein	116,141	ATP-Binding_Cassette_Transporter-2	4,38	Amyloid Precursor Protein	ATP-Binding Cassette Transporter-2	351	20	Gene	Gene	Gene|compound|START_ENTITY Levels|nmod|Gene END_ENTITY|dep|Levels	The ATP-Binding_Cassette_Transporter-2 -LRB- ABCA2 -RRB- Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid_Precursor_Protein -LRB- APP -RRB- Gene .
24898256	0	Amyloid_precursor_protein	0,25	APLP2	52,57	Amyloid precursor protein	APLP2	11820(Tax:10090)	11804(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Amyloid_precursor_protein -LRB- APP -RRB- / APP-like_protein_2 -LRB- APLP2 -RRB- expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan_sulfate .
24898256	0	Amyloid_precursor_protein	0,25	APP-like_protein_2	32,50	Amyloid precursor protein	APP-like protein 2	11820(Tax:10090)	11804(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Amyloid_precursor_protein -LRB- APP -RRB- / APP-like_protein_2 -LRB- APLP2 -RRB- expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan_sulfate .
17314098	0	Amyloid_precursor_protein	0,25	GRB2	68,72	Amyloid precursor protein	GRB2	351	2885	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Amyloid_precursor_protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK_1 ,2 signaling .
10766770	0	An3	31,34	CRM1	46,50	An3	CRM1	397935(Tax:8355)	399087(Tax:8355)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Nuclear export of the DEAD box An3 protein by CRM1 is coupled to An3 helicase activity .
26380810	0	AnCE	112,116	angiotensin_converting_enzyme	71,100	AnCE	angiotensin converting enzyme	34805(Tax:7227)	34805(Tax:7227)	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	A new high-resolution crystal structure of the Drosophila_melanogaster angiotensin_converting_enzyme homologue , AnCE .
16854031	0	AnO2	57,61	AnO2	66,70	AnO2	AnO2	57101	57101	Gene	Gene	START_ENTITY|dep|+ +|dep|+ +|compound|END_ENTITY	Quantum chemical calculations of reduction potentials of AnO2 -LRB- 2 + -RRB- / AnO2 + -LRB- An = U , Np , Pu , Am -RRB- and Fe3 + / Fe2 + couples .
16854031	0	AnO2	66,70	AnO2	57,61	AnO2	AnO2	57101	57101	Gene	Gene	+|compound|START_ENTITY +|dep|+ END_ENTITY|dep|+	Quantum chemical calculations of reduction potentials of AnO2 -LRB- 2 + -RRB- / AnO2 + -LRB- An = U , Np , Pu , Am -RRB- and Fe3 + / Fe2 + couples .
26613676	0	Anamorsin	68,77	BOLA2	44,49	Anamorsin	BOLA2	57019	552900	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway .
11684952	0	Anaplastic_lymphoma_kinase	0,26	ALK	28,31	Anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- expression in the inflammatory_myofibroblastic_tumor : a comparative immunohistochemical study .
26179668	0	Anaplastic_lymphoma_kinase	0,26	ALK	28,31	Anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- translocation in paediatric_malignant_peritoneal_mesothelioma : a case report of novel ALK-related tumour spectrum .
11850821	0	Anaplastic_lymphoma_kinase	0,26	Stat3	43,48	Anaplastic lymphoma kinase	Stat3	238	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- activates Stat3 and protects hematopoietic cells from cell death .
12093364	0	Ance	0,4	angiotensin-converting_enzyme	19,48	Ance	angiotensin-converting enzyme	34805(Tax:7227)	34805(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|amod|END_ENTITY	Ance , a Drosophila angiotensin-converting_enzyme homologue , is expressed in imaginal cells during metamorphosis and is regulated by the steroid , 20-hydroxyecdysone .
23093411	0	And-1	61,66	acidic_nucleoplasmic_DNA-binding_protein	19,59	And-1	acidic nucleoplasmic DNA-binding protein	11169	11169	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	The involvement of acidic_nucleoplasmic_DNA-binding_protein -LRB- And-1 -RRB- in the regulation of prereplicative complex -LRB- pre-RC -RRB- assembly in human cells .
24790336	0	Androgen_Receptor	23,40	AR	42,44	Androgen Receptor	AR	367	367	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Mutational Analysis of Androgen_Receptor -LRB- AR -RRB- Gene in 46 , XY Patients with Ambiguous_Genitalia and Normal Testosterone Secretion : Endocrinological Characteristics of Three Patients with AR Gene Mutations .
25228652	0	Androgen_Receptor	20,37	CtBP2	0,5	Androgen Receptor	CtBP2	367	1488	Gene	Gene	Modulates|dobj|START_ENTITY Modulates|nsubj|END_ENTITY	CtBP2 Modulates the Androgen_Receptor to Promote Prostate_Cancer Progression .
26207810	0	Androgen_Receptor	68,85	FKBP52	4,10	Androgen Receptor	FKBP52	367	2288	Gene	Gene	Signaling|compound|START_ENTITY Acts|nmod|Signaling Acts|compound|END_ENTITY	The FKBP52 Cochaperone Acts in Synergy with b-Catenin to Potentiate Androgen_Receptor Signaling .
26207810	0	Androgen_Receptor	68,85	FKBP52	4,10	Androgen Receptor	FKBP52	367	2288	Gene	Gene	Signaling|compound|START_ENTITY Acts|nmod|Signaling Acts|compound|END_ENTITY	The FKBP52 Cochaperone Acts in Synergy with b-Catenin to Potentiate Androgen_Receptor Signaling .
12114777	0	Androgen_Receptor	58,75	HUMARA	77,83	Androgen Receptor	HUMARA	367	367	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Clonality Analysis of Benign Parathyroid Lesions by Human Androgen_Receptor -LRB- HUMARA -RRB- Gene Assay .
26196517	0	Androgen_Receptor	18,35	Pten	59,63	Androgen Receptor	Pten	11835(Tax:10090)	19211(Tax:10090)	Gene	Gene	Variants|compound|START_ENTITY Identification|nmod|Variants Identification|nmod|Model Model|compound|END_ENTITY	Identification of Androgen_Receptor Splice Variants in the Pten Deficient Murine Prostate_Cancer Model .
26196517	0	Androgen_Receptor	18,35	Pten	59,63	Androgen Receptor	Pten	11835(Tax:10090)	19211(Tax:10090)	Gene	Gene	Variants|compound|START_ENTITY Identification|nmod|Variants Identification|nmod|Model Model|compound|END_ENTITY	Identification of Androgen_Receptor Splice Variants in the Pten Deficient Murine Prostate_Cancer Model .
26998759	0	Androgen_Receptor	30,47	Pten	71,75	Androgen Receptor	Pten	11835(Tax:10090)	19211(Tax:10090)	Gene	Gene	Variants|compound|START_ENTITY Variants|nmod|Model Model|compound|END_ENTITY	Correction : Identification of Androgen_Receptor Splice Variants in the Pten Deficient Murine Prostate_Cancer Model .
26448047	0	Androgen_Receptor	77,94	Sp1	3,6	Androgen Receptor	Sp1	367	6667	Gene	Gene	Activity|compound|START_ENTITY Modulated|nmod|Activity Modulated|nsubj|END_ENTITY	An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen_Receptor Promoter Activity in Prostate_Cancer Cells .
25890570	0	Androgen_Receptor	4,21	TGFBR2	102,108	Androgen Receptor	TGFBR2	367	7048	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Re : Androgen_Receptor and MicroRNA-21 Axis Downregulates Transforming_Growth_Factor_Beta_Receptor_II -LRB- TGFBR2 -RRB- Expression in Prostate_Cancer .
25890570	0	Androgen_Receptor	4,21	Transforming_Growth_Factor_Beta_Receptor_II	57,100	Androgen Receptor	Transforming Growth Factor Beta Receptor II	367	7048	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Re : Androgen_Receptor and MicroRNA-21 Axis Downregulates Transforming_Growth_Factor_Beta_Receptor_II -LRB- TGFBR2 -RRB- Expression in Prostate_Cancer .
26175158	0	Androgen_Receptor	43,60	USP7	28,32	Androgen Receptor	USP7	367	7874	Gene	Gene	Activity|compound|START_ENTITY Regulates|dobj|Activity Regulates|nsubj|END_ENTITY	The Deubiquitinating Enzyme USP7 Regulates Androgen_Receptor Activity by Modulating Its Binding to Chromatin .
22190929	0	Androgen_Receptor	0,17	ZEB1	49,53	Androgen Receptor	ZEB1	367	6935	Gene	Gene	Transcription|compound|START_ENTITY Transcription|nmod|Factor Factor|compound|END_ENTITY	Androgen_Receptor Regulates Transcription of the ZEB1 Transcription Factor .
22139837	0	Androgen_Receptor	0,17	p27	27,30	Androgen Receptor	p27	367	10671	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Androgen_Receptor Enhances p27 Degradation in Prostate_Cancer Cells through Rapid and Selective TORC2 Activation .
12014620	0	Androgen_receptor	0,17	AR	19,21	Androgen receptor	AR	367	367	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in normal and cancerous human endometrial tissues detected by RT-PCR and immunohistochemistry .
14963700	0	Androgen_receptor	0,17	AR	19,21	Androgen receptor	AR	367	367	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression is an independent unfavorable prognostic factor in gastric_cancer .
15368471	0	Androgen_receptor	0,17	AR	19,21	Androgen receptor	AR	367	367	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in AR-negative prostate_cancer cells results in differential effects of DHT and IGF-I on proliferation and AR activity between localized and metastatic_tumors .
22289337	0	Androgen_receptor	0,17	AR	19,21	Androgen receptor	AR	367	367	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in prostate_cancer and progression of the tumor : Lessons from cell lines , animal models and human specimens .
25057438	0	Androgen_receptor	0,17	AR	19,21	Androgen receptor	AR	367	367	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- expression in 400 breast_carcinomas : is routine AR assessment justified ?
25925349	0	Androgen_receptor	0,17	AR	19,21	Androgen receptor	AR	367	367	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- gene CAG trinucleotide repeat length associated with body composition measures in non-syndromic_obese , non-obese and Prader-Willi_syndrome individuals .
9344686	0	Androgen_receptor	0,17	AR	19,21	Androgen receptor	AR	24208(Tax:10116)	24208(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Androgen_receptor -LRB- AR -RRB- immunoreactivity in rat pudendal motoneurons : implications for accessory proteins .
23962788	0	Androgen_receptor	0,17	CD133	28,33	Androgen receptor	CD133	367	8842	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Androgen_receptor increases CD133 expression and progenitor-like population that associate with cisplatin resistance in endometrial_cancer cell line .
26063731	0	Androgen_receptor	0,17	CD25	52,56	Androgen receptor	CD25	367	3559	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|T-cells T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	Androgen_receptor	0,17	CD4	48,51	Androgen receptor	CD4	367	920	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|T-cells T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
23246967	0	Androgen_receptor	0,17	CHIP	47,51	Androgen receptor	CHIP	367	358	Gene	Gene	degradation|compound|START_ENTITY END_ENTITY|nsubj|degradation	Androgen_receptor degradation by the E3 ligase CHIP modulates mitotic_arrest in prostate_cancer cells .
24172884	0	Androgen_receptor	0,17	CMYC	28,32	Androgen receptor	CMYC	367	4609	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Androgen_receptor decreases CMYC and KRAS expression by upregulating let-7a expression in ER - , PR - , AR + breast_cancer .
15887248	0	Androgen_receptor	0,17	Cdc6	28,32	Androgen receptor	Cdc6	367	990	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Androgen_receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase .
26558456	0	Androgen_receptor	0,17	DEPTOR	71,77	Androgen receptor	DEPTOR	367	64798	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Androgen_receptor functions as a negative transcriptional regulator of DEPTOR , mTOR inhibitor .
19318561	0	Androgen_receptor	0,17	EGFR	27,31	Androgen receptor	EGFR	367	1956	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	Androgen_receptor controls EGFR and ERBB2 gene expression at different levels in prostate_cancer cell lines .
26487496	0	Androgen_receptor	0,17	EGFR	71,75	Androgen receptor	EGFR	367	1956	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Androgen_receptor promotes tamoxifen agonist activity by activation of EGFR in ERa-positive breast_cancer .
12430142	0	Androgen_receptor	0,17	FGF2	37,41	Androgen receptor	FGF2	367	2247	Gene	Gene	expression|amod|START_ENTITY induces|nsubj|expression induces|dobj|END_ENTITY	Androgen_receptor expression induces FGF2 , FGF-binding_protein production , and FGF2 release in prostate_carcinoma cells : role of FGF2 in growth , survival , and androgen_receptor down-modulation .
25008967	0	Androgen_receptor	0,17	FOXA1	73,78	Androgen receptor	FOXA1	367	3169	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|genes genes|nummod|END_ENTITY	Androgen_receptor and its splice variant , AR-V7 , differentially regulate FOXA1 sensitive genes in LNCaP_prostate_cancer cells .
21701558	0	Androgen_receptor	0,17	FoxA1	90,95	Androgen receptor	FoxA1	367	3169	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	Androgen_receptor driven transcription in molecular apocrine breast_cancer is mediated by FoxA1 .
26063731	0	Androgen_receptor	0,17	Foxp3	28,33	Androgen receptor	Foxp3	367	50943	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	Androgen_receptor	0,17	Foxp3	57,62	Androgen receptor	Foxp3	367	50943	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|T-cells T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
20460526	0	Androgen_receptor	0,17	JunD	27,31	Androgen receptor	JunD	367	3727	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Androgen_receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate_cancer cells .
17487836	0	Androgen_receptor	0,17	NFkappaB	26,34	Androgen receptor	NFkappaB	11835(Tax:10090)	18033(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Androgen_receptor targets NFkappaB and TSP1 to suppress prostate_tumor growth in vivo .
11997177	0	Androgen_receptor	0,17	Oct-1	36,41	Androgen receptor	Oct-1	11835(Tax:10090)	18986(Tax:10090)	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Androgen_receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct .
19276248	0	Androgen_receptor	0,17	PIK3CA	46,52	Androgen receptor	PIK3CA	367	5290	Gene	Gene	START_ENTITY|nmod|mutations mutations|nummod|END_ENTITY	Androgen_receptor levels and association with PIK3CA mutations and prognosis in breast_cancer .
10547578	0	Androgen_receptor	0,17	PSA	54,57	Androgen receptor	PSA	367	354	Gene	Gene	amplification|amod|START_ENTITY increases|nsubj|amplification increases|dobj|expression expression|compound|END_ENTITY	Androgen_receptor gene amplification increases tissue PSA protein expression in hormone-refractory prostate_carcinoma .
27028864	0	Androgen_receptor	0,17	SRC	28,31	Androgen receptor	SRC	367	6714	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Androgen_receptor regulates SRC expression through microRNA-203 .
25730905	0	Androgen_receptor	0,17	Src	86,89	Androgen receptor	Src	367	6714	Gene	Gene	regulation|amod|START_ENTITY mediated|nsubj|regulation mediated|nmod|END_ENTITY	Androgen_receptor non-nuclear regulation of prostate_cancer cell invasion mediated by Src and matriptase .
11451350	0	Androgen_receptor	0,17	cyclin	35,41	Androgen receptor	cyclin	367	18538(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Androgen_receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate_cancer xenograft .
14654929	0	Androgen_receptor	0,17	erbB-1	25,31	Androgen receptor	erbB-1	367	1956	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Androgen_receptor versus erbB-1 and erbB-2 expression in human prostate_neoplasms .
19638585	0	Androgen_receptor	0,17	estrogen_receptor-alpha	27,50	Androgen receptor	estrogen receptor-alpha	367	2099	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Androgen_receptor inhibits estrogen_receptor-alpha activity and is prognostic in breast_cancer .
10218991	0	Androgen_receptor	0,17	insulin-like_growth_factor_binding_protein-5	31,75	Androgen receptor	insulin-like growth factor binding protein-5	367	3488	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Androgen_receptor up-regulates insulin-like_growth_factor_binding_protein-5 -LRB- IGFBP-5 -RRB- expression in a human prostate_cancer xenograft .
15059919	0	Androgen_receptor	0,17	interleukin-6	42,55	Androgen receptor	interleukin-6	367	3569	Gene	Gene	signaling|compound|START_ENTITY signaling|dep|mechanism mechanism|nmod|inhibition inhibition|amod|END_ENTITY	Androgen_receptor signaling : mechanism of interleukin-6 inhibition .
24798454	0	Androgen_receptor	0,17	miR-1	172,177	Androgen receptor	miR-1	367	79187	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- inhibitor ErbB3-binding_protein-1 -LRB- Ebp1 -RRB- is not targeted by the newly identified AR controlling signaling axis_heat-shock_protein_HSP27 and microRNA miR-1 in prostate_cancer cells .
12051727	0	Androgen_receptor	0,17	myogenin	27,35	Androgen receptor	myogenin	11835(Tax:10090)	17928(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Androgen_receptor enhances myogenin expression and accelerates differentiation .
14668339	0	Androgen_receptor	0,17	phosphatidylinositol_3-OH_kinase	53,85	Androgen receptor	phosphatidylinositol 3-OH kinase	367	5295	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Androgen_receptor mediates non-genomic activation of phosphatidylinositol_3-OH_kinase in androgen-sensitive epithelial cells .
24037531	0	Androgen_receptor	0,17	transforming_growth_factor_beta_receptor_II	53,96	Androgen receptor	transforming growth factor beta receptor II	367	7048	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Androgen_receptor and microRNA-21 axis downregulates transforming_growth_factor_beta_receptor_II -LRB- TGFBR2 -RRB- expression in prostate_cancer .
15453096	0	Ang1	8,12	VEGF-A	38,44	Ang1	VEGF-A	284	7422	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Ang1 and its interaction with VEGF-A in astrocytomas .
11002428	2	Ang2	300,304	angiopoietin-2	284,298	Ang1	angiopoietin-1	284	284	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	High levels of angiopoietin-2 -LRB- Ang2 -RRB- mRNA are observed in vascular activation during tumorigenesis .
24588264	0	AngII	87,92	TGF-b1	69,75	AngII	TGF-b1	11606(Tax:10090)	21803(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The Ang - -LRB- 1-7 -RRB- / Mas-1 axis attenuates the expression and signalling of TGF-b1 induced by AngII in mouse skeletal muscle .
25143325	0	AngII	83,88	TRPC6	30,35	AngII	TRPC6	11606(Tax:10090)	22068(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|effects effects|nmod|END_ENTITY	The effects of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII .
12776518	0	AngII_receptor	57,71	AT-1	73,77	AngII receptor	AT-1	24180(Tax:10116)	24180(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Effect of zishuijianghuoyin on expression of lymphocyte AngII_receptor -LRB- AT-1 -RRB- mRNA of experimental hypertension rats -RSB- .
17559081	0	Ang_II	0,6	COX-2	38,43	Ang II	COX-2	24179(Tax:10116)	26198(Tax:10116)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Ang_II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells .
17559081	0	Ang_II	0,6	CREB	59,63	Ang II	CREB	24179(Tax:10116)	81646(Tax:10116)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Ang_II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells .
20722567	0	Ang_II	0,6	Ets-1	29,34	Ang II	Ets-1	11606(Tax:10090)	23871(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Ang_II enhances tubular cell Ets-1 expression and associated down stream signaling is mediated through AT1 receptors .
18182223	0	Ang_II_receptor_type_1	152,174	AT1	176,179	Ang II receptor type 1	AT1	185	185	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II _ -LRB- Ang_II -RRB- evoked secretion of the human_placental_lactogen -LRB- HPL -RRB- in intrauterine_growth_retardation : examination of the relationship with Ang_II_receptor_type_1 -LRB- AT1 -RRB- expression .
26753798	0	Angiogenin	32,42	ANG	44,47	Angiogenin	ANG	283	283	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Lack of association between the Angiogenin -LRB- ANG -RRB- rs11701 polymorphism and amyotrophic_lateral_sclerosis risk : a meta-analysis .
21937427	0	Angiomotin-like2	0,16	amotl2	23,29	Angiomotin-like2	amotl2	558920(Tax:7955)	558920(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Angiomotin-like2 gene -LRB- amotl2 -RRB- is required for migration and proliferation of endothelial cells during angiogenesis .
23613948	0	Angiopoietin-1	93,107	Angiopoietin-2	41,55	Angiopoietin-1	Angiopoietin-2	11600(Tax:10090)	11601(Tax:10090)	Gene	Gene	maturation|nmod|START_ENTITY maturation|compound|END_ENTITY	Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia .
24563688	0	Angiopoietin-1	0,14	IL-1b	49,54	Angiopoietin-1	IL-1b	284	3553	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Angiopoietin-1 upregulates de novo expression of IL-1b and Il1-Ra , and the exclusive release of Il1-Ra from human neutrophils .
22015631	0	Angiopoietin-1	0,14	IL-8	46,50	Angiopoietin-1	IL-8	284	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|compound|END_ENTITY	Angiopoietin-1 but not angiopoietin-2 induces IL-8 synthesis and release by human neutrophils .
21885850	0	Angiopoietin-1	0,14	IQ_domain_GTPase-activating_protein_1	24,61	Angiopoietin-1	IQ domain GTPase-activating protein 1	284	8826	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	Angiopoietin-1 requires IQ_domain_GTPase-activating_protein_1 to activate Rac1 and promote endothelial barrier defense .
25997931	0	Angiopoietin-1	96,110	PTK7	0,4	Angiopoietin-1	PTK7	11600(Tax:10090)	71461(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	PTK7 + Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1 .
15823283	0	Angiopoietin-1	0,14	VEGF	72,76	Angiopoietin-1	VEGF	284	7422	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Angiopoietin-1 and angiopoietin-2 in diabetes_mellitus : relationship to VEGF , glycaemic control , endothelial_damage / dysfunction and atherosclerosis .
16723371	0	Angiopoietin-1	0,14	angiopoietin-2	16,30	Angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Angiopoietin-1 , angiopoietin-2 and Tie-2 expression in eutopic endometrium in advanced endometriosis .
19478794	0	Angiopoietin-1	0,14	angiopoietin-2	15,29	Angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	Angiopoietin-1 / angiopoietin-2 ratio for prediction of preeclampsia .
21113176	0	Angiopoietin-1	0,14	angiopoietin-2	72,86	Angiopoietin-1	angiopoietin-2	11600(Tax:10090)	11601(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|function function|acl|blunted blunted|nmod|glucose_condition glucose_condition|amod|END_ENTITY	Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose_condition .
22505659	0	Angiopoietin-1	0,14	angiopoietin-2	70,84	Angiopoietin-1	angiopoietin-2	11600(Tax:10090)	11601(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inhibition inhibition|nmod|release release|nmod|END_ENTITY	Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells .
17562701	0	Angiopoietin-1	0,14	p190_RhoGAP	24,35	Angiopoietin-1	p190 RhoGAP	11600(Tax:10090)	232906(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	Angiopoietin-1 requires p190_RhoGAP to protect against vascular_leakage in vivo .
23613948	0	Angiopoietin-2	41,55	Angiopoietin-1	93,107	Angiopoietin-2	Angiopoietin-1	11601(Tax:10090)	11600(Tax:10090)	Gene	Gene	maturation|compound|START_ENTITY maturation|nmod|END_ENTITY	Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia .
22792348	0	Angiopoietin-2	0,14	TAL1	53,57	Angiopoietin-2	TAL1	285	6886	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Angiopoietin-2 is a direct transcriptional target of TAL1 , LYL1 and LMO2 in endothelial cells .
22585576	0	Angiopoietin-2	0,14	TIE2	61,65	Angiopoietin-2	TIE2	285	7010	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signaling signaling|compound|END_ENTITY	Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling .
25312939	0	Angiopoietin-2	14,28	Tie-2	29,34	Angiopoietin-2	Tie-2	285	7010	Gene	Gene	Targeting|dobj|START_ENTITY axis|dep|Targeting axis|compound|END_ENTITY	Targeting the Angiopoietin-2 / Tie-2 axis in conjunction with VEGF signal interference .
23065888	0	Angiopoietin-2	0,14	Tie2	15,19	Angiopoietin-2	Tie2	285	7010	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Angiopoietin-2 / Tie2 signaling involved in TNF-a induced peritoneal angiogenesis .
23149917	0	Angiopoietin-2	0,14	Tie2	30,34	Angiopoietin-2	Tie2	285	7010	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Angiopoietin-2 functions as a Tie2 agonist in tumor models , where it limits the effects of VEGF inhibition .
9204896	0	Angiopoietin-2	0,14	Tie2	41,45	Angiopoietin-2	Tie2	11601(Tax:10090)	21687(Tax:10090)	Gene	Gene	angiogenesis|advmod|START_ENTITY angiogenesis|nsubj|antagonist antagonist|nmod|END_ENTITY	Angiopoietin-2 , a natural antagonist for Tie2 that disrupts in vivo angiogenesis .
23149917	0	Angiopoietin-2	0,14	VEGF	91,95	Angiopoietin-2	VEGF	285	7422	Gene	Gene	functions|amod|START_ENTITY agonist|nsubj|functions agonist|advcl|limits limits|dobj|effects effects|nmod|inhibition inhibition|compound|END_ENTITY	Angiopoietin-2 functions as a Tie2 agonist in tumor models , where it limits the effects of VEGF inhibition .
25312939	0	Angiopoietin-2	14,28	VEGF	60,64	Angiopoietin-2	VEGF	285	7422	Gene	Gene	Targeting|dobj|START_ENTITY axis|dep|Targeting axis|nmod|conjunction conjunction|nmod|interference interference|amod|END_ENTITY	Targeting the Angiopoietin-2 / Tie-2 axis in conjunction with VEGF signal interference .
21680733	0	Angiopoietin-2	0,14	integrin-linked_kinase	130,152	Angiopoietin-2	integrin-linked kinase	285	3611	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Angiopoietin-2 , an angiogenic regulator , promotes initial_growth_and_survival_of_breast_cancer metastases to the lung through the integrin-linked_kinase -LRB- ILK -RRB- - AKT-B cell lymphoma 2 -LRB- Bcl-2 -RRB- pathway .
12861074	0	Angiopoietin-2	0,14	matrix_metalloprotease-2	71,95	Angiopoietin-2	matrix metalloprotease-2	285	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Angiopoietin-2 induces human glioma invasion through the activation of matrix_metalloprotease-2 .
15095288	0	Angiopoietin-2	0,14	vascular_endothelial_growth_factor	54,88	Angiopoietin-2	vascular endothelial growth factor	11601(Tax:10090)	22339(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Angiopoietin-2 enhances retinal vessel sensitivity to vascular_endothelial_growth_factor .
17704802	0	Angiopoietin-2	0,14	vascular_endothelial_growth_factor	25,59	Angiopoietin-2	vascular endothelial growth factor	285	7422	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Angiopoietin-2 decreases vascular_endothelial_growth_factor expression by modulating HIF-1_alpha levels in gliomas .
21163623	0	Angiopoietin-2	0,14	vascular_endothelial_growth_factor	87,121	Angiopoietin-2	vascular endothelial growth factor	11601(Tax:10090)	22339(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|affecting affecting|dobj|expression expression|nmod|END_ENTITY	Angiopoietin-2 inhibits the growth of tongue_carcinoma without affecting expression of vascular_endothelial_growth_factor .
22267746	0	Angiopoietin-like_4	0,19	Angptl4	21,28	Angiopoietin-like 4	Angptl4	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Angiopoietin-like_4 -LRB- Angptl4 -RRB- protein is a physiological mediator of intracellular lipolysis in murine adipocytes .
27034464	0	Angiopoietin-like_4	0,19	lipoprotein_lipase	68,86	Angiopoietin-like 4	lipoprotein lipase	57875(Tax:10090)	16956(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Angiopoietin-like_4 -LRB- ANGPTL4 -RRB- promotes intracellular degradation of lipoprotein_lipase in adipocytes .
23205131	0	Angiopoietin-like_protein	0,25	ANGPTL2	26,33	Angiopoietin-like protein	ANGPTL2	26360(Tax:10090)	26360(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Angiopoietin-like_protein ANGPTL2 gene expression is correlated with lymph node metastasis in lung_cancer .
20581395	0	Angiopoietin-like_protein_3	0,27	lipoprotein_lipase	37,55	Angiopoietin-like protein 3	lipoprotein lipase	27329	4023	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Angiopoietin-like_protein_3 inhibits lipoprotein_lipase activity through enhancing its cleavage by proprotein convertases .
23960078	0	Angiopoietin-like_protein_4	0,27	lipoprotein_lipase	42,60	Angiopoietin-like protein 4	lipoprotein lipase	51129	4023	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Angiopoietin-like_protein_4 inhibition of lipoprotein_lipase : evidence for reversible complex formation .
11801735	0	Angiopoietin_2	0,14	c-Fes	122,127	Angiopoietin 2	c-Fes	11601(Tax:10090)	14159(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Angiopoietin_2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn .
26162198	0	Angiotensin-1_Converting_Enzyme	116,147	ACE	149,152	Angiotensin-1 Converting Enzyme	ACE	1636	1636	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Heterogeneity of Physical Function Responses to Exercise in Older Adults : Possible Contribution of Variation in the Angiotensin-1_Converting_Enzyme -LRB- ACE -RRB- Gene ?
21331722	0	Angiotensin-Converting_Enzyme	18,47	ACE	49,52	Angiotensin-Converting Enzyme	ACE	1636	1636	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Quantification of Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Activity .
25807210	0	Angiotensin-Converting_Enzyme	15,44	ACE	45,48	Angiotensin-Converting Enzyme	ACE	1636	1636	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Association of Angiotensin-Converting_Enzyme ACE Gene Polymorphism with ACE Activity and Susceptibility to Vitiligo in Egyptian Population .
26177100	0	Angiotensin-Converting_Enzyme	15,44	ACE	46,49	Angiotensin-Converting Enzyme	ACE	1636	1636	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Gene Polymorphism with Inflammation and Cellular Cytotoxicity in Vitiligo Patients .
26180887	0	Angiotensin-Converting_Enzyme	0,29	ACE	31,34	Angiotensin-Converting Enzyme	ACE	1636	1636	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Angiotensin-Converting_Enzyme -LRB- ACE -RRB- Inhibitors : A Review of the Comparative Clinical and Cost-Effectiveness This purpose of this report is to update a 2008 CADTH Rapid Response report on the comparative clinical and cost-effectiveness of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
20479968	0	Angiotensin-I-converting_enzyme	0,31	ACE	33,36	Angiotensin-I-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Angiotensin-I-converting_enzyme -LRB- ACE -RRB- inhibitors from marine resources : prospects in the pharmaceutical industry .
24343777	0	Angiotensin-II	0,14	ERK1/2	42,48	Angiotensin-II	ERK1/2	183	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Angiotensin-II induces phosphorylation of ERK1/2 and promotes aortic adventitial fibroblasts differentiating into myofibroblasts during aortic_dissection formation .
1491687	0	Angiotensin-II	0,14	plasminogen_activator_inhibitor-1	28,61	Angiotensin-II	plasminogen activator inhibitor-1	24179(Tax:10116)	24617(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Angiotensin-II induction of plasminogen_activator_inhibitor-1 gene expression in astroglial cells of normotensive and spontaneously hypertensive rat brain .
11168787	0	Angiotensin-converting_enzyme	0,29	ACE	31,34	Angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- gene polymorphisms and familial occurrence of sarcoidosis .
16395257	0	Angiotensin-converting_enzyme	0,29	ACE	31,34	Angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition in type 2 , diabetic patients -- interaction with ACE insertion/deletion polymorphism .
20600611	0	Angiotensin-converting_enzyme	0,29	ACE	31,34	Angiotensin-converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors exacerbate histological damage and motor_deficits after experimental traumatic_brain_injury .
8046841	0	Angiotensin-converting_enzyme	1,30	ACE	32,35	Angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	-LSB- Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphism and serum ACE activities in sarcoidosis -RSB- .
8573745	0	Angiotensin-converting_enzyme	0,29	ACE	31,34	Angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- gene polymorphism in type II diabetic patients with increased albumin excretion rate .
18158355	0	Angiotensin-converting_enzyme	0,29	angiotensin_I	78,91	Angiotensin-converting enzyme	angiotensin I	11421(Tax:10090)	11606(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY site|nsubj|domain site|nmod|cleavage cleavage|amod|END_ENTITY	Angiotensin-converting_enzyme C-terminal catalytic domain is the main site of angiotensin_I cleavage in vivo .
12103271	0	Angiotensin-converting_enzyme	0,29	bradykinin	162,172	Angiotensin-converting enzyme	bradykinin	610668(Tax:9615)	478666(Tax:9615)	Gene	Gene	inhibitors|amod|START_ENTITY increase|nsubj|inhibitors increase|dobj|flow flow|dep|role role|nmod|END_ENTITY	Angiotensin-converting_enzyme inhibitors and angiotensin_II_receptor_blockers synergistically increase coronary blood flow in canine ischemic myocardium : role of bradykinin .
12235256	0	Angiotensin-converting_enzyme	0,29	bradykinin	122,132	Angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	angioedema|amod|START_ENTITY characterized|nsubjpass|angioedema characterized|nmod|degradation degradation|nmod|des-arginine des-arginine|dep|END_ENTITY	Angiotensin-converting_enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine -LRB- 9 -RRB- - bradykinin .
12566370	0	Angiotensin-converting_enzyme	0,29	bradykinin	127,137	Angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY increases|nsubj|inhibition increases|nmod|END_ENTITY	Angiotensin-converting_enzyme inhibition increases human vascular tissue-type_plasminogen_activator release through endogenous bradykinin .
15055254	0	Angiotensin-converting_enzyme	0,29	bradykinin	136,146	Angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	polymorphism|amod|START_ENTITY modulates|nsubj|polymorphism modulates|nmod|END_ENTITY	Angiotensin-converting_enzyme insertion/deletion polymorphism modulates coronary release of tissue_plasminogen_activator in response to bradykinin .
16219810	0	Angiotensin-converting_enzyme	0,29	bradykinin	40,50	Angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Angiotensin-converting_enzyme regulates bradykinin receptor gene expression .
15950509	0	Angiotensin_Converting_Enzyme	23,52	ACE	54,57	Angiotensin Converting Enzyme	ACE	1636	1636	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No association between Angiotensin_Converting_Enzyme -LRB- ACE -RRB- gene variation and endurance athlete status in Kenyans .
25922179	0	Angiotensin_Converting_Enzyme	95,124	ACE	126,129	Angiotensin Converting Enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design , synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin_Converting_Enzyme -LRB- ACE -RRB- inhibitors .
27062780	0	Angiotensin_Converting_Enzyme_2	22,53	ACE2	55,59	Angiotensin Converting Enzyme 2	ACE2	302668(Tax:10116)	302668(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Protective Effect of Angiotensin_Converting_Enzyme_2 -LRB- ACE2 -RRB- Against Chronic Intermittent Hypoxia-induced Pulmonary_Oxidative_Stress_Injury in Rats -RSB- .
12566298	0	Angiotensin_I-converting_enzyme	0,31	ACE	33,36	Angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene polymorphism and breast_cancer risk among Chinese women in Singapore .
21495912	0	Angiotensin_I-converting_enzyme	0,31	ACE	33,36	Angiotensin I-converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Angiotensin_I-converting_enzyme -LRB- ACE -RRB- activity and expression in rat central nervous system after sleep_deprivation .
21496083	0	Angiotensin_I-converting_enzyme	37,68	ACE	70,73	Angiotensin I-converting enzyme	ACE	100064801(Tax:9796)	100064801(Tax:9796)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of two training protocols on Angiotensin_I-converting_enzyme -LRB- ACE -RRB- activity in horses .
12911547	0	Angiotensin_II	0,14	11beta-hydroxysteroid_dehydrogenase_type_2	25,67	Angiotensin II	11beta-hydroxysteroid dehydrogenase type 2	183	3291	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Angiotensin_II regulates 11beta-hydroxysteroid_dehydrogenase_type_2 via AT2 receptors .
9020107	0	Angiotensin_II	0,14	4E-binding_protein_1	73,93	Angiotensin II	4E-binding protein 1	183	1978	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Angiotensin_II stimulates phosphorylation of the translational repressor 4E-binding_protein_1 by a mitogen-activated protein kinase-independent mechanism .
10755201	0	Angiotensin_II	0,14	ACE	60,63	Angiotensin II	ACE	183	1636	Gene	Gene	formation|compound|START_ENTITY formation|nmod|vasculature vasculature|nmod|inhibition inhibition|compound|END_ENTITY	Angiotensin_II formation in human vasculature after chronic ACE inhibition : a prospective , randomized , placebo-controlled study .
1660550	0	Angiotensin_II	0,14	ACE	82,85	Angiotensin II	ACE	183	1636	Gene	Gene	reverse|nsubj|START_ENTITY reverse|nmod|inhibition inhibition|compound|END_ENTITY	Angiotensin_II does not acutely reverse the reduction of proteinuria by long-term ACE inhibition .
18403595	0	Angiotensin_II	0,14	ACE	61,64	Angiotensin II	ACE	183	1636	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|angiotensin_I-converting_enzyme angiotensin_I-converting_enzyme|appos|END_ENTITY	Angiotensin_II up-regulates angiotensin_I-converting_enzyme -LRB- ACE -RRB- , but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway .
9362242	0	Angiotensin_II	0,14	ACE	30,33	Angiotensin II	ACE	183	1636	Gene	Gene	formation|compound|START_ENTITY formation|nmod|END_ENTITY	Angiotensin_II formation from ACE and chymase in human and animal hearts : methods and species considerations .
9800878	0	Angiotensin_II	0,14	ACE	48,51	Angiotensin II	ACE	183	1636	Gene	Gene	formation|compound|START_ENTITY formation|dep|END_ENTITY	Angiotensin_II formation in the human heart : an ACE or non-ACE-mediated pathway ?
3521328	0	Angiotensin_II	0,14	ADH	51,54	Angiotensin II	ADH	183	551	Gene	Gene	inhibition|nsubj|START_ENTITY inhibition|nmod|END_ENTITY	Angiotensin_II inhibition with captopril on plasma ADH , PG synthesis , and renal function in humans .
14521934	0	Angiotensin_II	0,14	AP-1	28,32	Angiotensin II	AP-1	24179(Tax:10116)	24516(Tax:10116)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Angiotensin_II induction of AP-1 in neurons requires stimulation of PI3-K and JNK .
19465003	0	Angiotensin_II	0,14	AP-1	94,98	Angiotensin II	AP-1	183	3727	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Angiotensin_II induces type I collagen gene expression in human dermal fibroblasts through an AP-1 / TGF-beta1-dependent pathway .
9207128	0	Angiotensin_II	0,14	AP-1	61,65	Angiotensin II	AP-1	183	3727	Gene	Gene	type1a|nsubj|START_ENTITY type1a|parataxis|participate participate|nsubj|END_ENTITY	Angiotensin_II type1a receptor gene expression in the heart : AP-1 and GATA-4 participate in the response to pressure overload .
10484450	0	Angiotensin_II	0,14	AT1	96,99	Angiotensin II	AT1	183	185	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|growth growth|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT1 receptors .
10693967	0	Angiotensin_II	0,14	AT1	90,93	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|dep|ATPase ATPase|nmod|astrocytes astrocytes|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II modulates the activity of Na + , K + - ATPase in cultured rat astrocytes via the AT1 receptor and protein_kinase_C-delta activation .
11369817	0	Angiotensin_II	0,14	AT1	124,127	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|nmod|mice mice|compound|END_ENTITY	Angiotensin_II activates nuclear transcription factor-kappaB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice .
12028439	0	Angiotensin_II	0,14	AT1	69,72	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|receptors receptors|compound|END_ENTITY	Angiotensin_II activates nuclear transcription factor-kappaB through AT1 and AT2 receptors .
12056548	0	Angiotensin_II	0,14	AT1	42,45	Angiotensin II	AT1	183	185	Gene	Gene	bound|nsubjpass|START_ENTITY bound|nmod|END_ENTITY	Angiotensin_II is bound to both receptors AT1 and AT2 , parallel to the transmembrane domains and in an extended form .
12623987	0	Angiotensin_II	0,14	AT1	29,32	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Angiotensin_II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR .
1338078	0	Angiotensin_II	0,14	AT1	136,139	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|cells cells|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells via the angiotensin_II AT1 receptor .
14744924	0	Angiotensin_II	0,14	AT1	91,94	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II stimulates calcium and nitric_oxide release from Macula densa cells through AT1 receptors .
15143297	0	Angiotensin_II	0,14	AT1	15,18	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Angiotensin_II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats .
15153562	0	Angiotensin_II	0,14	AT1	20,23	Angiotensin II	AT1	11606(Tax:10090)	11607(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Angiotensin_II , via AT1 and AT2 receptors and NF-kappaB pathway , regulates the inflammatory response in unilateral_ureteral_obstruction .
1554376	0	Angiotensin_II	0,14	AT1	111,114	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Angiotensin_II exerts its effect on aldosterone production and potassium permeability through receptor subtype AT1 in rat adrenal glomerulosa cells .
16522324	0	Angiotensin_II	0,14	AT1	96,99	Angiotensin II	AT1	183	185	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|cascade cascade|nmod|crosstalk crosstalk|nmod|receptors receptors|compound|END_ENTITY	Angiotensin_II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic_scars .
17081374	0	Angiotensin_II	1,15	AT1	122,125	Angiotensin II	AT1	183	185	Gene	Gene	expression|compound|START_ENTITY expression|dep|roles roles|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Angiotensin_II up-regulates expression of inducible nitric_oxide synthase in human umbilical endothelial cells : roles of AT1 and AT2 -RSB- .
1878151	0	Angiotensin_II	1,15	AT1	57,60	Angiotensin II	AT1	183	185	Gene	Gene	receptors|compound|START_ENTITY -RSB-|nsubj|receptors -RSB-|compound|END_ENTITY	-LSB- Angiotensin_II receptors in the human placenta are type AT1 -RSB- .
21109230	0	Angiotensin_II	0,14	AT1	89,92	Angiotensin II	AT1	11606(Tax:10090)	11607(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II induces interleukin-6 synthesis in osteoblasts through ERK1/2 pathway via AT1 receptor .
22128421	0	Angiotensin_II	0,14	AT1	51,54	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|vasoconstriction vasoconstriction|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats .
22128423	0	Angiotensin_II	0,14	AT1	91,94	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|dep|role role|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II pressor response in the L-NAME-induced hypertensive pithed rat : role of the AT1 receptor .
23946289	0	Angiotensin_II	0,14	AT1	50,53	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY attenuates|nsubj|activation attenuates|dobj|increases increases|nummod|END_ENTITY	Angiotensin_II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin : a multiphoton microscopy study .
25109430	0	Angiotensin_II	0,14	AT1	116,119	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|xcomp|sympathoexcitation sympathoexcitation|nmod|receptor receptor|nummod|END_ENTITY	Angiotensin_II in paraventricular nucleus contributes to sympathoexcitation in renal_ischemia-reperfusion injury by AT1 receptor and oxidative stress .
25172944	0	Angiotensin_II	0,14	AT1	119,122	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	mobilizes|nsubj|START_ENTITY carotid|dep|mobilizes carotid|nsubj|cells cells|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors .
25365520	0	Angiotensin_II	58,72	AT1	46,49	Angiotensin II	AT1	24179(Tax:10116)	185	Gene	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Transcriptional Network Analysis Reveals that AT1 and AT2 Angiotensin_II Receptors Are Both Involved in the Regulation of Genes Essential for Glioma Progression .
25429176	0	Angiotensin_II	20,34	AT1	35,38	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Blockade of Central Angiotensin_II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats .
25431019	0	Angiotensin_II	0,14	AT1	31,34	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	START_ENTITY|acl|acting acting|nmod|receptors receptors|compound|END_ENTITY	Angiotensin_II acting on brain AT1 receptors induces adrenaline secretion and pressor responses in the rat .
25808928	0	Angiotensin_II	20,34	AT1	70,73	Angiotensin II	AT1	183	185	Gene	Gene	Molecular|compound|START_ENTITY Characterization|nmod|Molecular Determinants|nsubj|Characterization Determinants|xcomp|Involved Involved|nmod|Selectivity Selectivity|compound|END_ENTITY	Characterization of Angiotensin_II Molecular Determinants Involved in AT1 Receptor Functional Selectivity .
26613735	0	Angiotensin_II	6,20	AT1	21,24	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Brain Angiotensin_II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive_alterations .
7476884	0	Angiotensin_II	0,14	AT1	57,60	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|receptor receptor|compound|END_ENTITY	Angiotensin_II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms : evidence for homologous and heterologous regulation .
7704434	0	Angiotensin_II	0,14	AT1	92,95	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	effects|compound|START_ENTITY mediated|nsubjpass|effects mediated|nmod|receptor receptor|nummod|END_ENTITY	Angiotensin_II effects on second messengers involved in prolactin secretion are mediated by AT1 receptor in anterior pituitary cells .
7881045	0	Angiotensin_II	0,14	AT1	15,18	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Angiotensin_II AT1 receptor mediated contraction of the perfused rat cerebral artery .
8124662	0	Angiotensin_II	0,14	AT1	100,103	Angiotensin II	AT1	183	185	Gene	Gene	elevates|nsubj|START_ENTITY elevates|dobj|calcium calcium|nmod|cells cells|nmod|activation activation|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II elevates cytosolic free calcium in human lung_adenocarcinoma cells via activation of AT1 receptors .
8127007	0	Angiotensin_II	0,14	AT1	110,113	Angiotensin II	AT1	183	185	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|receptors receptors|amod|binding binding|nmod|END_ENTITY	Angiotensin_II stimulates human fetal mesangial cell proliferation and fibronectin biosynthesis by binding to AT1 receptors .
8394907	0	Angiotensin_II	0,14	AT1	96,99	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|cyclase cyclase|nmod|receptor receptor|appos|END_ENTITY	Angiotensin_II inhibits glomerular adenylate cyclase via the angiotensin_II receptor subtype 1 -LRB- AT1 -RRB- .
8566350	0	Angiotensin_II	0,14	AT1	48,51	Angiotensin II	AT1	183	185	Gene	Gene	receptors|compound|START_ENTITY cells|nsubj|receptors cells|advmod|exclusively exclusively|nmod|subtype subtype|compound|END_ENTITY	Angiotensin_II receptors are exclusively of the AT1 subtype in cultured human vascular smooth muscle cells .
8950291	0	Angiotensin_II	0,14	AT1	33,36	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	START_ENTITY|nmod|action action|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II , via an action at AT1 receptors , may modulate the behavioural effects of ET-1 in conscious rats .
9003008	0	Angiotensin_II	0,14	AT1	33,36	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY subtypes|nsubj|receptor subtypes|ccomp|down-regulated down-regulated|nsubjpass|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9003008	0	Angiotensin_II	0,14	AT1	90,93	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY subtypes|nsubj|receptor subtypes|ccomp|down-regulated down-regulated|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9709394	0	Angiotensin_II	0,14	AT1	32,35	Angiotensin II	AT1	183	185	Gene	Gene	receptor|compound|START_ENTITY subtype|nsubj|receptor subtype|dobj|expression expression|compound|END_ENTITY	Angiotensin_II receptor subtype AT1 and AT2 expression after heart transplantation .
9791081	0	Angiotensin_II	0,14	AT1	23,26	Angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex .
9334403	0	Angiotensin_II	0,14	AT1A	15,19	Angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Angiotensin_II AT1A receptor mRNA expression is induced by estrogen-progesterone in dopaminergic neurons of the female rat arcuate nucleus .
15502641	0	Angiotensin_II	0,14	AT1R	99,103	Angiotensin II	AT1R	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Angiotensin_II mediates acinar cell apoptosis during the development of rat pancreatic_fibrosis by AT1R .
20458733	0	Angiotensin_II	0,14	AT1R	47,51	Angiotensin II	AT1R	183	185	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|signaling signaling|appos|END_ENTITY	Angiotensin_II / angiotensin_II type I receptor -LRB- AT1R -RRB- signaling promotes MCF-7 breast_cancer cells survival via PI3-kinase/Akt pathway .
22020146	0	Angiotensin_II	0,14	AT1R	88,92	Angiotensin II	AT1R	11606(Tax:10090)	11610(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|pathway pathway|amod|dependent dependent|advmod|END_ENTITY	Angiotensin_II induces extracellular_matrix_metalloproteinase_inducer expression via an AT1R dependent pathway in aortic_atherosclerotic_plaque in apolipoprotein_E knockout mice .
25767191	0	Angiotensin_II	0,14	AT1R	103,107	Angiotensin II	AT1R	183	185	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|cells cells|nmod|END_ENTITY	Angiotensin_II increases matrix_metalloproteinase_2 expression in human aortic smooth muscle cells via AT1R and ERK1/2 .
16198631	0	Angiotensin_II	0,14	AT1_receptor	15,27	Angiotensin II	AT1 receptor	183	185	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	Angiotensin_II AT1_receptor density on blood platelets predicts early left ventricular remodelling in non-reperfused acute myocardial_infarction in humans .
22844079	0	Angiotensin_II	0,14	AT1_receptor	38,50	Angiotensin II	AT1 receptor	11606(Tax:10090)	11610(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|damage damage|nmod|Nox4 Nox4|compound|END_ENTITY	Angiotensin_II induces DNA damage via AT1_receptor and NADPH oxidase isoform Nox4 .
15551065	0	Angiotensin_II	0,14	AT2	54,57	Angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	blocks|nsubj|START_ENTITY blocks|nmod|mechanism mechanism|compound|END_ENTITY	Angiotensin_II blocks memory consolidation through an AT2 receptor-dependent mechanism .
16220978	0	Angiotensin_II	0,14	AT2	90,93	Angiotensin II	AT2	183	186	Gene	Gene	pseudopeptides|nsubj|START_ENTITY pseudopeptides|xcomp|containing containing|nmod|affinity affinity|compound|END_ENTITY	Angiotensin_II pseudopeptides containing 1,3,5-trisubstituted _ benzene scaffolds with high AT2 receptor affinity .
1908781	0	Angiotensin_II	0,14	AT2	15,18	Angiotensin II	AT2	183	186	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Angiotensin_II AT2 receptors do not interact with guanine_nucleotide binding proteins .
19129693	0	Angiotensin_II	0,14	AT2	65,68	Angiotensin II	AT2	183	186	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|parataxis|role role|nmod|receptors receptors|nummod|END_ENTITY	Angiotensin_II upregulates RAGE expression on podocytes : role of AT2 receptors .
22776205	0	Angiotensin_II	0,14	AT2	76,79	Angiotensin II	AT2	183	186	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II induces apoptosis in intestinal epithelial cells through the AT2 receptor , GATA-6 and the Bax pathway .
23573410	0	Angiotensin_II	56,70	AT2	52,55	Angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	Subtypes|compound|START_ENTITY Subtypes|compound|END_ENTITY	Immunohistochemical Localization of AT1a , AT1b , and AT2 Angiotensin_II Receptor Subtypes in the Rat Adrenal , Pituitary , and Brain with a Perspective Commentary .
23946289	0	Angiotensin_II	0,14	AT2	15,18	Angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Angiotensin_II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin : a multiphoton microscopy study .
7972928	0	Angiotensin_II	0,14	AT2	15,18	Angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	increases|compound|START_ENTITY increases|compound|END_ENTITY	Angiotensin_II AT2 receptor stimulation increases cerebrovascular resistance during hemorrhagic hypotension in rats .
9453004	0	Angiotensin_II	0,14	AT2	98,101	Angiotensin II	AT2	183	186	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II inhibits growth of cultured embryonic renomedullary interstitial cells through the AT2 receptor .
9473667	0	Angiotensin_II	0,14	AT2	97,100	Angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	influence|nsubj|START_ENTITY influence|dobj|proteins proteins|dep|role role|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II and NGF differentially influence microtubule proteins in PC12W cells : role of the AT2 receptor .
15153556	0	Angiotensin_II	0,14	AT2_receptor	72,84	Angiotensin II	AT2 receptor	11606(Tax:10090)	11609(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|cells cells|nmod|END_ENTITY	Angiotensin_II increases Pax-2 expression in fetal kidney cells via the AT2_receptor .
23349663	0	Angiotensin_II	0,14	AdipoR1	31,38	Angiotensin II	AdipoR1	24179(Tax:10116)	289036(Tax:10116)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1 / 2/c-Myc pathway .
24098385	0	Angiotensin_II	0,14	Akt	100,103	Angiotensin II	Akt	183	207	Gene	Gene	START_ENTITY|dep|participation participation|nmod|modulation modulation|nmod|END_ENTITY	Angiotensin_II signaling in human preadipose cells : participation of ERK1,2-dependent modulation of Akt .
21030269	0	Angiotensin_II	102,116	Ap-1	21,25	Angiotensin II	Ap-1	183	3725	Gene	Gene	exposed|nmod|START_ENTITY cells|acl|exposed mediates|nmod|cells mediates|nsubj|END_ENTITY	Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothelial cells exposed to Angiotensin_II .
25870189	0	Angiotensin_II	0,14	Arhgef1	50,57	Angiotensin II	Arhgef1	183	9138	Gene	Gene	Activates|nsubj|START_ENTITY Activates|dobj|END_ENTITY	Angiotensin_II Activates the RhoA Exchange Factor Arhgef1 in Humans .
22659879	0	Angiotensin_II	0,14	Bim	39,42	Angiotensin II	Bim	183	10018	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Angiotensin_II regulates activation of Bim via Rb/E2F1 during apoptosis : involvement of interaction between AMPKb1/2 and Cdk4 .
20538278	0	Angiotensin_II	0,14	C-reactive_protein	23,41	Angiotensin II	C-reactive protein	183	1401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces C-reactive_protein expression through ERK1/2 and JNK signaling in human aortic endothelial cells .
24021937	0	Angiotensin_II	0,14	C-reactive_protein	23,41	Angiotensin II	C-reactive protein	183	1401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces C-reactive_protein expression via AT1-ROS-MAPK-NF-kB signal pathway in hepatocytes .
21814216	0	Angiotensin_II	0,14	CCL5	34,38	Angiotensin II	CCL5	24179(Tax:10116)	81780(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Angiotensin_II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats .
17692319	0	Angiotensin_II	0,14	CD11b	48,53	Angiotensin II	CD11b	183	3684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Angiotensin_II AT1 receptor blockade normalizes CD11b + monocyte production in bone marrow of hypercholesterolemic monkeys .
19837408	0	Angiotensin_II	0,14	CD62L	23,28	Angiotensin II	CD62L	183	6402	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiotensin_II induces CD62L shedding in human neutrophils .
22749815	0	Angiotensin_II	0,14	CTGF	25,29	Angiotensin II	CTGF	183	1490	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Angiotensin_II increases CTGF expression via MAPKs/TGF-b 1/TRAF6 pathway in atrial fibroblasts .
19915801	0	Angiotensin_II	0,14	CX3CR1	28,34	Angiotensin II	CX3CR1	183	1524	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Angiotensin_II up-regulates CX3CR1 expression in THP-1 monocytes : impact on vascular_inflammation and atherogenesis .
20451562	0	Angiotensin_II	0,14	EMMPRIN	23,30	Angiotensin II	EMMPRIN	183	682	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Angiotensin_II induces EMMPRIN expression in THP-1 macrophages via the NF-kappaB pathway .
15698454	0	Angiotensin_II	0,14	ERK1/2	88,94	Angiotensin II	ERK1/2	183	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|END_ENTITY	Angiotensin_II induces fibronectin expression in human peritoneal mesothelial cells via ERK1/2 and p38_MAPK .
16139272	0	Angiotensin_II	0,14	ERK1/2	60,66	Angiotensin II	ERK1/2	24179(Tax:10116)	50689;116590	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|nitration nitration|nmod|END_ENTITY	Angiotensin_II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells .
16253189	0	Angiotensin_II	1,15	ERK1/2	125,131	Angiotensin II	ERK1/2	183	5595;5594	Gene	Gene	START_ENTITY|dep|expression expression|nmod|cells cells|nmod|activation activation|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Angiotensin_II and aldosterone_stimulate alpha1 - -LRB- I -RRB- procollagen mRNA expression in hepatic stellate cells via activation of ERK1/2 and AP-1 -RSB- .
17380010	0	Angiotensin_II	0,14	ERK1/2	92,98	Angiotensin II	ERK1/2	183	5595;5594	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|formation formation|nmod|END_ENTITY	Angiotensin_II inhibits insulin-induced actin stress fiber formation and glucose uptake via ERK1/2 .
20538278	0	Angiotensin_II	0,14	ERK1/2	61,67	Angiotensin II	ERK1/2	183	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Angiotensin_II induces C-reactive_protein expression through ERK1/2 and JNK signaling in human aortic endothelial cells .
21109230	0	Angiotensin_II	0,14	ERK1/2	70,76	Angiotensin II	ERK1/2	11606(Tax:10090)	26417;26413	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nummod|END_ENTITY	Angiotensin_II induces interleukin-6 synthesis in osteoblasts through ERK1/2 pathway via AT1 receptor .
26379274	0	Angiotensin_II	78,92	ERK1/2	115,121	Angiotensin II	ERK1/2	24179(Tax:10116)	50689;116590	Gene	Gene	Proliferation|nmod|START_ENTITY Proliferation|nmod|END_ENTITY	Exendin-4 Prevents Vascular Smooth Muscle Cell Proliferation and Migration by Angiotensin_II via the Inhibition of ERK1/2 and JNK Signaling Pathways .
25250890	0	Angiotensin_II	0,14	Endothelial_Lipase	27,45	Angiotensin II	Endothelial Lipase	183	9388	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25742014	0	Angiotensin_II	12,26	Endothelial_Lipase	39,57	Angiotensin II	Endothelial Lipase	183	9388	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Correction : Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
12110003	0	Angiotensin_II	0,14	Flt-1	78,83	Angiotensin II	Flt-1	24179(Tax:10116)	54251(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Angiotensin_II regulation of vascular_endothelial_growth_factor and receptors Flt-1 and KDR/Flk -1 in cyclosporine nephrotoxicity .
9421421	0	Angiotensin_II	0,14	Fos-regulating_kinase	40,61	Angiotensin II	Fos-regulating kinase	24179(Tax:10116)	79209(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Angiotensin_II stimulates activation of Fos-regulating_kinase and c-Jun_NH2-terminal_kinase in neuronal cultures from rat brain .
17109863	0	Angiotensin_II	0,14	IL-6	23,27	Angiotensin II	IL-6	11847(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Angiotensin_II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL_receptor-deficient mice .
18716376	0	Angiotensin_II	0,14	IP-10	39,44	Angiotensin II	IP-10	183	3627	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II increases expression of IP-10 and the renin-angiotensin system in endothelial cells .
25955575	0	Angiotensin_II	0,14	JNK	153,156	Angiotensin II	JNK	183	5599	Gene	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Increase Increase|nmod|Expression Expression|nmod|Cells Cells|nmod|END_ENTITY	Angiotensin_II Induces an Increase in Matrix_Metalloproteinase_2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic_Aneurysms Through JNK , ERK1/2 , and p38 MAPK Activation .
25955575	0	Angiotensin_II	0,14	JNK	153,156	Angiotensin II	JNK	183	5599	Gene	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Increase Increase|nmod|Expression Expression|nmod|Cells Cells|nmod|END_ENTITY	Angiotensin_II Induces an Increase in Matrix_Metalloproteinase_2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic_Aneurysms Through JNK , ERK1/2 , and p38 MAPK Activation .
26126628	0	Angiotensin_II	0,14	JNK	111,114	Angiotensin II	JNK	24179(Tax:10116)	116554(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
9648723	0	Angiotensin_II	0,14	JNK	102,105	Angiotensin II	JNK	24179(Tax:10116)	116554(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|role role|nmod|activation activation|nmod|END_ENTITY	Angiotensin_II stimulates p21-activated kinase in vascular smooth muscle cells : role in activation of JNK .
21813872	0	Angiotensin_II	0,14	Janus_kinase_2	24,38	Angiotensin II	Janus kinase 2	24179(Tax:10116)	24514(Tax:10116)	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|END_ENTITY	Angiotensin_II utilizes Janus_kinase_2 in hypertension , but not in the physiological control of blood pressure , during low-salt intake .
18281370	0	Angiotensin_II	0,14	LDL_receptor-related_protein	27,55	Angiotensin II	LDL receptor-related protein	183	4035	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II upregulates LDL_receptor-related_protein -LRB- LRP1 -RRB- expression in the vascular wall : a new pro-atherogenic mechanism of hypertension .
10468518	0	Angiotensin_II	0,14	LOX-1	23,28	Angiotensin II	LOX-1	183	4973	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiotensin_II induces LOX-1 , the human endothelial receptor for oxidized low-density lipoprotein .
17893372	0	Angiotensin_II	0,14	LOX-1	74,79	Angiotensin II	LOX-1	11606(Tax:10090)	108078(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|pathway pathway|amod|dependent dependent|amod|END_ENTITY	Angiotensin_II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
1871416	0	Angiotensin_II	0,14	MAO	25,28	Angiotensin II	MAO	24179(Tax:10116)	29253(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Angiotensin_II increases MAO activity in rat central nervous system .
19448902	0	Angiotensin_II	0,14	MCP-1	26,31	Angiotensin II	MCP-1	24179(Tax:10116)	24770(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Angiotensin_II stimulates MCP-1 production in rat glomerular endothelial cells via NAD -LRB- P -RRB- H oxidase-dependent nuclear factor-kappa B signaling .
15670768	0	Angiotensin_II	0,14	MMP-2	23,28	Angiotensin II	MMP-2	183	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiotensin_II induces MMP-2 in a p47phox-dependent manner .
24219285	0	Angiotensin_II	0,14	MMP-2	58,63	Angiotensin II	MMP-2	183	4313	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|enhancement enhancement|nmod|activity activity|compound|END_ENTITY	Angiotensin_II downregulates ACE2-mediated enhancement of MMP-2 activity in human cardiofibroblasts .
26071572	0	Angiotensin_II	0,14	MMP-2	38,43	Angiotensin II	MMP-2	183	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|increase increase|nmod|expresison expresison|compound|END_ENTITY	Angiotensin_II induces an increase in MMP-2 expresison in idiopathic_ascending_aortic_aneurysm via AT1 receptor and JNK pathway .
23277113	0	Angiotensin_II	0,14	MMP-3	41,46	Angiotensin II	MMP-3	183	4314	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Angiotensin_II induces the production of MMP-3 and MMP-13 through the MAPK signaling pathways via the AT -LRB- 1 -RRB- receptor in osteoblasts .
25501305	0	Angiotensin_II	54,68	MiR-30a	8,15	Angiotensin II	MiR-30a	24179(Tax:10116)	100314011(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of MiR-30a in cardiomyocyte autophagy induced by Angiotensin_II .
22555025	0	Angiotensin_II	0,14	Morg1	40,45	Angiotensin II	Morg1	11606(Tax:10090)	67836(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II differentially regulates Morg1 expression in kidney cells .
25250890	0	Angiotensin_II	0,14	NF-Kappa_B	65,75	Angiotensin II	NF-Kappa B	183	4790	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Signaling Signaling|compound|END_ENTITY	Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25742014	0	Angiotensin_II	12,26	NF-Kappa_B	77,87	Angiotensin II	NF-Kappa B	183	4790	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Correction : Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
23576578	0	Angiotensin_II	0,14	NF-kB	25,30	Angiotensin II	NF-kB	24179(Tax:10116)	309165(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Angiotensin_II activates NF-kB through AT1A receptor recruitment of b-arrestin in cultured rat vascular smooth muscle cells .
11108147	0	Angiotensin_II	0,14	NF-kappaB	108,117	Angiotensin II	NF-kappaB	183	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|effects effects|nmod|factor factor|appos|END_ENTITY	Angiotensin_II induces gene transcription through cell-type-dependent effects on the nuclear_factor-kappaB -LRB- NF-kappaB -RRB- transcription factor .
15130920	0	Angiotensin_II	0,14	NF-kappaB	121,130	Angiotensin II	NF-kappaB	183	4790	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|adipocytes adipocytes|nmod|activation activation|nmod|END_ENTITY	Angiotensin_II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB .
17097193	0	Angiotensin_II	0,14	NF-kappa_B	23,33	Angiotensin II	NF-kappa B	183	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	Angiotensin_II induces NF-kappa_B activation in HUVEC via the p38MAPK pathway .
12911544	0	Angiotensin_II	0,14	NHE3	26,30	Angiotensin II	NHE3	183	6550	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Angiotensin_II stimulates NHE3 activity by exocytic insertion of the transporter : role of PI 3-kinase .
19338654	0	Angiotensin_II	0,14	NHE3	56,60	Angiotensin II	NHE3	183	6550	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Angiotensin_II directly regulates intestinal epithelial NHE3 in Caco2BBE cells .
20386492	0	Angiotensin_II	0,14	NOS	25,28	Angiotensin II	NOS	183	4842	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Angiotensin_II regulates NOS expression in afferent arterioles of the developing porcine kidney .
19517575	0	Angiotensin_II	0,14	PAX2	28,32	Angiotensin II	PAX2	183	5076	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Angiotensin_II up-regulates PAX2 oncogene expression and activity in prostate_cancer via the angiotensin_II type I receptor .
16842674	0	Angiotensin_II	1,15	PTEN	58,62	Angiotensin II	PTEN	24179(Tax:10116)	50557(Tax:10116)	Gene	Gene	induced|compound|START_ENTITY blocked|nsubjpass|induced blocked|nmod|END_ENTITY	-LSB- Angiotensin_II induced cardiac_hypertrophy is blocked by PTEN via suppressing Ca2 + / Calcineurin pathway -RSB- .
15153556	0	Angiotensin_II	0,14	Pax-2	25,30	Angiotensin II	Pax-2	11606(Tax:10090)	18504(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Angiotensin_II increases Pax-2 expression in fetal kidney cells via the AT2_receptor .
15569307	0	Angiotensin_II	0,14	Pax-2	26,31	Angiotensin II	Pax-2	24179(Tax:10116)	293992(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Angiotensin_II stimulates Pax-2 in rat kidney proximal tubular cells : impact on proliferation and apoptosis .
16051229	0	Angiotensin_II	0,14	RAGE	90,94	Angiotensin II	RAGE	24179(Tax:10116)	81722(Tax:10116)	Gene	Gene	augments|compound|START_ENTITY advanced|nsubj|augments advanced|ccomp|end end|nmod|overexpression overexpression|amod|END_ENTITY	Angiotensin_II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression .
19129693	0	Angiotensin_II	0,14	RAGE	27,31	Angiotensin II	RAGE	183	5891	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II upregulates RAGE expression on podocytes : role of AT2 receptors .
25250989	0	Angiotensin_II	0,14	Renin	48,53	Angiotensin II	Renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	Increases|nsubj|START_ENTITY Increases|dobj|Expression Expression|nmod|Receptor Receptor|compound|END_ENTITY	Angiotensin_II Increases the Expression of -LRB- Pro -RRB- Renin Receptor During Low-Salt Conditions .
19692654	0	Angiotensin_II	0,14	RhoA	23,27	Angiotensin II	RhoA	183	387	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	Angiotensin_II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells .
22613986	0	Angiotensin_II	0,14	SOCS3	79,84	Angiotensin II	SOCS3	183	9021	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Angiotensin_II induces angiogenic factors production partly via AT1/JAK2/STAT3 / SOCS3 signaling pathway in MHCC97H cells .
15894808	0	Angiotensin_II	0,14	SR-BI	34,39	Angiotensin II	SR-BI	24179(Tax:10116)	25073(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|receptor receptor|compound|END_ENTITY	Angiotensin_II down-regulates the SR-BI HDL receptor in proximal tubular cells .
21915376	0	Angiotensin_II	54,68	Stat3	31,36	Angiotensin II	Stat3	183	6774	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Jak2-Independent Activation of Stat3 by Intracellular Angiotensin_II in Human Mesangial Cells .
8798409	0	Angiotensin_II	0,14	Stat3	53,58	Angiotensin II	Stat3	183	6774	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	Angiotensin_II interferes with interleukin_6-induced Stat3 signaling by a pathway involving mitogen-activated_protein_kinase_kinase_1 .
9144332	0	Angiotensin_II	0,14	Stat3	79,84	Angiotensin II	Stat3	24179(Tax:10116)	25125(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Angiotensin_II stimulates rapid serine phosphorylation of transcription factor Stat3 .
9602424	0	Angiotensin_II	0,14	Stat5	25,30	Angiotensin II	Stat5	24179(Tax:10116)	24918(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Angiotensin_II activates Stat5 through Jak2 kinase in cardiac myocytes .
25345602	0	Angiotensin_II	0,14	TGF-b	36,41	Angiotensin II	TGF-b	183	7040	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Angiotensin_II stimulates canonical TGF-b signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction .
25676696	0	Angiotensin_II	12,26	TGF-b	48,53	Angiotensin II	TGF-b	183	7040	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Erratum to : Angiotensin_II stimulates canonical TGF-b signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction .
15770925	0	Angiotensin_II	0,14	TGF-beta1	45,54	Angiotensin II	TGF-beta1	183	7040	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Angiotensin_II mediates high glucose-induced TGF-beta1 and fibronectin upregulation in HPMC through reactive oxygen species .
12107734	0	Angiotensin_II	0,14	TGF-beta_1	29,39	Angiotensin II	TGF-beta 1	183	7040	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	Angiotensin_II induces human TGF-beta_1 promoter activation : similarity to hyperglycaemia .
8061046	0	Angiotensin_II	0,14	TGF-beta_1	23,33	Angiotensin II	TGF-beta 1	24179(Tax:10116)	59086(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Angiotensin_II induces TGF-beta_1 production in rat heart endothelial cells .
9893729	0	Angiotensin_II	0,14	TGF-beta_1	79,89	Angiotensin II	TGF-beta 1	24179(Tax:10116)	59086(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|hypertrophy hypertrophy|nmod|release release|acl|END_ENTITY	Angiotensin_II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta_1 and endothelin-1 from fibroblasts .
19915801	0	Angiotensin_II	0,14	THP-1	49,54	Angiotensin II	THP-1	183	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|monocytes monocytes|compound|END_ENTITY	Angiotensin_II up-regulates CX3CR1 expression in THP-1 monocytes : impact on vascular_inflammation and atherogenesis .
8664344	0	Angiotensin_II	0,14	TIMP-1	23,29	Angiotensin II	TIMP-1	24179(Tax:10116)	116510(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Angiotensin_II induces TIMP-1 production in rat heart endothelial cells .
9458834	0	Angiotensin_II	0,14	TNF	23,26	Angiotensin II	TNF	183	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Angiotensin_II induces TNF production by the thick ascending limb : functional implications .
23154814	0	Angiotensin_II	0,14	TSLP	23,27	Angiotensin II	TSLP	24179(Tax:10116)	688621(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiotensin_II induces TSLP via an AT1 receptor/NF-KappaB pathway , promoting Th17 differentiation .
19271152	0	Angiotensin_II	0,14	Toll-like_receptor_4	27,47	Angiotensin II	Toll-like receptor 4	24179(Tax:10116)	29260(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Angiotensin_II upregulates Toll-like_receptor_4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells .
16249273	0	Angiotensin_II	0,14	VEGF	30,34	Angiotensin II	VEGF	183	7422	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|translation translation|compound|END_ENTITY	Angiotensin_II stimulation of VEGF mRNA translation requires production of reactive oxygen species .
18354258	0	Angiotensin_II	0,14	VEGF	50,54	Angiotensin II	VEGF	24179(Tax:10116)	83785(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II induces the vascular expression of VEGF and MMP-2 in vivo : preventive effect of red wine polyphenols .
15971150	0	Angiotensin_II	0,14	adrenomedullin	34,48	Angiotensin II	adrenomedullin	183	133	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Angiotensin_II stimulates cardiac adrenomedullin production and causes accumulation of mature adrenomedullin independently of hemodynamic stress in vivo .
15971150	0	Angiotensin_II	0,14	adrenomedullin	94,108	Angiotensin II	adrenomedullin	183	133	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Angiotensin_II stimulates cardiac adrenomedullin production and causes accumulation of mature adrenomedullin independently of hemodynamic stress in vivo .
10532681	0	Angiotensin_II	0,14	apolipoprotein_E	33,49	Angiotensin II	apolipoprotein E	11606(Tax:10090)	11816(Tax:10090)	Gene	Gene	atherogenicity|compound|START_ENTITY atherogenicity|nmod|mice mice|amod|END_ENTITY	Angiotensin_II atherogenicity in apolipoprotein_E deficient mice is associated with increased cellular cholesterol biosynthesis .
17785354	0	Angiotensin_II	0,14	apolipoprotein_E	35,51	Angiotensin II	apolipoprotein E	183	348	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Angiotensin_II regulates adipocyte apolipoprotein_E expression .
22020146	0	Angiotensin_II	0,14	apolipoprotein_E	147,163	Angiotensin II	apolipoprotein E	11606(Tax:10090)	11816(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|pathway pathway|nmod|aortic_atherosclerotic_plaque aortic_atherosclerotic_plaque|nmod|mice mice|amod|END_ENTITY	Angiotensin_II induces extracellular_matrix_metalloproteinase_inducer expression via an AT1R dependent pathway in aortic_atherosclerotic_plaque in apolipoprotein_E knockout mice .
19776169	0	Angiotensin_II	0,14	aquaporin_1	59,70	Angiotensin II	aquaporin 1	24179(Tax:10116)	25240(Tax:10116)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Angiotensin_II and hypertonicity modulate proximal tubular aquaporin_1 expression .
19628677	0	Angiotensin_II	0,14	c-Jun	72,77	Angiotensin II	c-Jun	183	3725	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Angiotensin_II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells .
18158102	0	Angiotensin_II	0,14	c-Jun_N-terminal_kinase	72,95	Angiotensin II	c-Jun N-terminal kinase	24179(Tax:10116)	116554(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Angiotensin_II induces proliferation of cultured rat astrocytes through c-Jun_N-terminal_kinase .
7565768	0	Angiotensin_II	0,14	c-Jun_N-terminal_kinase	58,81	Angiotensin II	c-Jun N-terminal kinase	24179(Tax:10116)	116554(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Angiotensin_II stimulates calcium-dependent activation of c-Jun_N-terminal_kinase .
8978332	0	Angiotensin_II	0,14	c-Jun_NH2-terminal_kinase	26,51	Angiotensin II	c-Jun NH2-terminal kinase	24179(Tax:10116)	116554(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Angiotensin_II stimulates c-Jun_NH2-terminal_kinase in cultured cardiac myocytes of neonatal rats .
2737716	0	Angiotensin_II	0,14	c-fos	23,28	Angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces c-fos expression in smooth muscle via transcriptional control .
2827679	0	Angiotensin_II	0,14	c-fos	41,46	Angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	Angiotensin_II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells .
2909538	0	Angiotensin_II	0,14	c-fos	23,28	Angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|amod|END_ENTITY	Angiotensin_II induces c-fos mRNA in aortic smooth muscle .
7539537	0	Angiotensin_II	0,14	c-fos	31,36	Angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|amod|END_ENTITY	Angiotensin_II induces in vivo c-fos expression from rat renal cortex and medulla .
7581259	0	Angiotensin_II	0,14	c-fos	41,46	Angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Angiotensin_II induces the expression of c-fos mRNA in the central nervous system of the rat .
7784900	0	Angiotensin_II	1,15	c-fos	24,29	Angiotensin II	c-fos	183	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	-LSB- Angiotensin_II induces c-fos and c-myc proto-oncogene expression in the left ventricle -RSB- .
9200737	0	Angiotensin_II	0,14	c-fos	121,126	Angiotensin II	c-fos	183	2353	Gene	Gene	interacts|nsubj|START_ENTITY interacts|parataxis|mapping mapping|nmod|END_ENTITY	Angiotensin_II interacts with nitric_oxide-cyclic_GMP pathway in the central control of drinking behaviour : mapping with c-fos and NADPH-diaphorase .
21325823	0	Angiotensin_II	0,14	c-reactive_protein	41,59	Angiotensin II	c-reactive protein	183	1401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II induces the expression of c-reactive_protein via MAPK-dependent signal pathway in U937 macrophages .
21660462	0	Angiotensin_II	0,14	catalase	29,37	Angiotensin II	catalase	183	847	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II downregulates catalase expression and activity in vascular adventitial fibroblasts through an AT1R/ERK1/2-dependent pathway .
16963053	0	Angiotensin_II	0,14	cathepsin_F	53,64	Angiotensin II	cathepsin F	183	8722	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II increases expression and secretion of cathepsin_F in cultured human monocyte-derived macrophages : an angiotensin_II_type_2_receptor-mediated effect .
12819040	0	Angiotensin_II	0,14	connective_tissue_growth_factor	23,54	Angiotensin II	connective tissue growth factor	24179(Tax:10116)	64032(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Angiotensin_II induces connective_tissue_growth_factor gene expression via calcineurin-dependent pathways .
14578193	0	Angiotensin_II	0,14	connective_tissue_growth_factor	25,56	Angiotensin II	connective tissue growth factor	24179(Tax:10116)	64032(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Angiotensin_II increases connective_tissue_growth_factor in the kidney .
19667256	0	Angiotensin_II	0,14	connective_tissue_growth_factor	23,54	Angiotensin II	connective tissue growth factor	24179(Tax:10116)	64032(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Angiotensin_II induces connective_tissue_growth_factor and collagen I expression via transforming growth factor-beta-dependent and - independent Smad pathways : the role of Smad3 .
17624368	0	Angiotensin_II	0,14	connexin43	34,44	Angiotensin II	connexin43	183	2697	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Angiotensin_II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits .
10194467	0	Angiotensin_II	0,14	cyclooxygenase-2	41,57	Angiotensin II	cyclooxygenase-2	24179(Tax:10116)	29527(Tax:10116)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II attenuates renal cortical cyclooxygenase-2 expression .
11880319	0	Angiotensin_II	0,14	cyclooxygenase-2	26,42	Angiotensin II	cyclooxygenase-2	24179(Tax:10116)	29527(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II stimulates cyclooxygenase-2 mRNA expression in renal tissue from rats with kidney_failure .
12388637	0	Angiotensin_II	0,14	cyclooxygenase-2	39,55	Angiotensin II	cyclooxygenase-2	183	5743	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Angiotensin_II increases expression of cyclooxygenase-2 : implications for the function of vascular smooth muscle cells .
15525649	0	Angiotensin_II	0,14	cyclooxygenase-2	50,66	Angiotensin II	cyclooxygenase-2	24179(Tax:10116)	29527(Tax:10116)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Angiotensin_II and epidermal_growth_factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways .
18543083	0	Angiotensin_II	0,14	cyclooxygenase-2	42,58	Angiotensin II	cyclooxygenase-2	24179(Tax:10116)	29527(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II bi-directionally regulates cyclooxygenase-2 expression in intestinal epithelial cells .
21169864	0	Angiotensin_II	0,14	cyclooxygenase-2	40,56	Angiotensin II	cyclooxygenase-2	24179(Tax:10116)	29527(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II differentially modulates cyclooxygenase-2 , microsomal prostaglandin_E2 synthase-1 and prostaglandin_I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli .
10029562	0	Angiotensin_II	0,14	endothelin-1	40,52	Angiotensin II	endothelin-1	183	1906	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|nmod|cells cells|amod|END_ENTITY	Angiotensin_II increases the release of endothelin-1 from human cultured endothelial cells but does not regulate its circulating levels .
1333547	0	Angiotensin_II	0,14	endothelin-1	26,38	Angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Angiotensin_II stimulates endothelin-1 secretion in cultured rat mesangial cells .
14732213	0	Angiotensin_II	0,14	endothelin-1	23,35	Angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces endothelin-1 gene expression via extracellular_signal-regulated_kinase pathway in rat aortic smooth muscle cells .
16188896	0	Angiotensin_II	0,14	endothelin-1	64,76	Angiotensin II	endothelin-1	11606(Tax:10090)	13614(Tax:10090)	Gene	Gene	sensitivity|compound|START_ENTITY arterioles|nsubj|sensitivity arterioles|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Angiotensin_II sensitivity of afferent glomerular arterioles in endothelin-1 transgenic_mice .
16515797	0	Angiotensin_II	0,14	endothelin-1	66,78	Angiotensin II	endothelin-1	183	1906	Gene	Gene	effect|compound|START_ENTITY effect|dep|interaction interaction|nmod|factor factor|amod|activating activating|dep|END_ENTITY	Angiotensin_II effect on hydraulic permeability : interaction with endothelin-1 , nitric_oxide , and platelet activating factor .
16911918	0	Angiotensin_II	144,158	endothelin-1	20,32	Angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|Effects Effects|nmod|antagonists antagonists|amod|END_ENTITY	Effects of specific endothelin-1 receptor antagonists on proliferation and fibronectin production of glomerular mesangial cells stimulated with Angiotensin_II .
23625292	0	Angiotensin_II	0,14	endothelin-1	23,35	Angiotensin II	endothelin-1	183	1906	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces endothelin-1 expression in human hepatic stellate cells .
8488329	0	Angiotensin_II	1,15	endothelin-1	27,39	Angiotensin II	endothelin-1	183	1906	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	-LSB- Angiotensin_II stimulates endothelin-1 release from human endothelial cells -RSB- .
10583422	0	Angiotensin_II	0,14	erythropoietin	25,39	Angiotensin II	erythropoietin	183	2056	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Angiotensin_II increases erythropoietin production in healthy human volunteers .
11422739	0	Angiotensin_II	0,14	erythropoietin	41,55	Angiotensin II	erythropoietin	183	2056	Gene	Gene	infusion|compound|START_ENTITY increases|nsubj|infusion increases|dobj|levels levels|compound|END_ENTITY	Angiotensin_II infusion increases plasma erythropoietin levels via an angiotensin_II_type_1_receptor-dependent pathway .
22020146	0	Angiotensin_II	0,14	extracellular_matrix_metalloproteinase_inducer	23,69	Angiotensin II	extracellular matrix metalloproteinase inducer	11606(Tax:10090)	12215(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Angiotensin_II induces extracellular_matrix_metalloproteinase_inducer expression via an AT1R dependent pathway in aortic_atherosclerotic_plaque in apolipoprotein_E knockout mice .
12031795	0	Angiotensin_II	0,14	focal_adhesion_kinase	29,50	Angiotensin II	focal adhesion kinase	183	5747	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Angiotensin_II activation of focal_adhesion_kinase and pp60c-Src in relation to mitogen-activated protein kinases in hepatocytes .
15652490	0	Angiotensin_II	0,14	focal_adhesion_kinase	23,44	Angiotensin II	focal adhesion kinase	183	5747	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Angiotensin_II induces focal_adhesion_kinase / paxillin phosphorylation and cell migration in human umbilical vein endothelial cells .
15680482	0	Angiotensin_II	0,14	growth_arrest_specific_homeobox	26,57	Angiotensin II	growth arrest specific homeobox	183	4223	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Angiotensin_II suppresses growth_arrest_specific_homeobox -LRB- Gax -RRB- expression via redox-sensitive mitogen-activated protein kinase -LRB- MAPK -RRB- .
15001568	0	Angiotensin_II	0,14	iNOS	82,86	Angiotensin II	iNOS	24179(Tax:10116)	24599(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Angiotensin_II differentially regulates interleukin-1-beta-inducible_NO_synthase -LRB- iNOS -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression : role of p38 MAPK .
16322063	0	Angiotensin_II	0,14	insulin-like_growth_factor_I_receptor	43,80	Angiotensin II	insulin-like growth factor I receptor	24179(Tax:10116)	25718(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Angiotensin_II stimulates transcription of insulin-like_growth_factor_I_receptor in vascular smooth muscle cells : role of nuclear factor-kappaB .
7575404	0	Angiotensin_II	0,14	insulin_receptor_substrate_1	51,79	Angiotensin II	insulin receptor substrate 1	24179(Tax:10116)	25467(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Angiotensin_II induces tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with phosphatidylinositol 3-kinase in rat heart .
9139682	0	Angiotensin_II	0,14	insulin_receptor_substrate_1	69,97	Angiotensin II	insulin receptor substrate 1	24179(Tax:10116)	25467(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Angiotensin_II stimulates tyrosine phosphorylation and activation of insulin_receptor_substrate_1 and protein-tyrosine_phosphatase_1D in vascular smooth muscle cells .
16293568	0	Angiotensin_II	0,14	integrin_beta3	38,52	Angiotensin II	integrin beta3	183	3690	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II stimulates endothelial integrin_beta3 expression via nuclear_factor-kappaB activation .
10517737	0	Angiotensin_II	0,14	intercellular_adhesion_molecule-1	26,59	Angiotensin II	intercellular adhesion molecule-1	183	3383	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II stimulates intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo .
16343550	0	Angiotensin_II	0,14	intercellular_adhesion_molecule-1	26,59	Angiotensin II	intercellular adhesion molecule-1	183	3383	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|pathway pathway|amod|END_ENTITY	Angiotensin_II stimulates intercellular_adhesion_molecule-1 via an AT1 receptor/nuclear factor-kappaB pathway in brain microvascular endothelial cells .
3112250	0	Angiotensin_II	0,14	interferon-gamma	25,41	Angiotensin II	interferon-gamma	183	3458	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Angiotensin_II regulates interferon-gamma production .
15860756	0	Angiotensin_II	0,14	interleukin-18	24,38	Angiotensin II	interleukin-18	11606(Tax:10090)	16173(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Angiotensin_II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells : a novel cross-talk in the pathogenesis of atherosclerosis .
10189357	0	Angiotensin_II	0,14	interleukin-6	23,36	Angiotensin II	interleukin-6	24179(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	Angiotensin_II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors .
11557673	0	Angiotensin_II	0,14	interleukin-6	119,132	Angiotensin II	interleukin-6	11606(Tax:10090)	16193(Tax:10090)	Gene	Gene	administration|compound|START_ENTITY increases|nsubj|administration increases|dobj|uptake uptake|dep|role role|nmod|END_ENTITY	Angiotensin_II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl : a possible role for interleukin-6 .
15130920	0	Angiotensin_II	0,14	interleukin-6	41,54	Angiotensin II	interleukin-6	183	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|acl|END_ENTITY	Angiotensin_II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB .
17043157	0	Angiotensin_II	0,14	interleukin-6	23,36	Angiotensin II	interleukin-6	183	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Angiotensin_II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism .
21109230	0	Angiotensin_II	0,14	interleukin-6	23,36	Angiotensin II	interleukin-6	11606(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Angiotensin_II induces interleukin-6 synthesis in osteoblasts through ERK1/2 pathway via AT1 receptor .
7579076	0	Angiotensin_II	0,14	interleukin-6	26,39	Angiotensin II	interleukin-6	11606(Tax:10090)	16193(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Angiotensin_II stimulates interleukin-6 release from cultured mouse mesangial cells .
15797645	0	Angiotensin_II	0,14	lectin-like_oxidized_low-density_lipoprotein_receptor-1	43,98	Angiotensin II	lectin-like oxidized low-density lipoprotein receptor-1	183	4973	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Angiotensin_II increases the expression of lectin-like_oxidized_low-density_lipoprotein_receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway .
24063596	0	Angiotensin_II	0,14	leptin	60,66	Angiotensin II	leptin	24179(Tax:10116)	25608(Tax:10116)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|induction induction|nmod|END_ENTITY	Angiotensin_II and the ERK pathway mediate the induction of leptin by mechanical cyclic stretch in cultured rat neonatal cardiomyocytes .
21720156	0	Angiotensin_II	0,14	mTOR	29,33	Angiotensin II	mTOR	24179(Tax:10116)	21977(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Angiotensin_II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin .
25767191	0	Angiotensin_II	0,14	matrix_metalloproteinase_2	25,51	Angiotensin II	matrix metalloproteinase 2	183	4313	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Angiotensin_II increases matrix_metalloproteinase_2 expression in human aortic smooth muscle cells via AT1R and ERK1/2 .
16251426	0	Angiotensin_II	0,14	matrix_metalloproteinase_type_II	25,57	Angiotensin II	matrix metalloproteinase type II	24179(Tax:10116)	81686(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Angiotensin_II activates matrix_metalloproteinase_type_II and mimics age-associated carotid arterial remodeling in young rats .
26828982	0	Angiotensin_II	0,14	monocarboxylate_transporters	28,56	Angiotensin II	monocarboxylate transporters	24179(Tax:10116)	25027(Tax:10116)	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Angiotensin_II up-regulates monocarboxylate_transporters expression in the rat adrenal gland .
16705055	0	Angiotensin_II	0,14	monocyte_chemoattractant_protein-1	23,57	Angiotensin II	monocyte chemoattractant protein-1	24179(Tax:10116)	24770(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces monocyte_chemoattractant_protein-1 expression via a nuclear factor-kappaB-dependent pathway in rat preadipocytes .
19429670	0	Angiotensin_II	0,14	monocyte_chemoattractant_protein-1	40,74	Angiotensin II	monocyte chemoattractant protein-1	183	6347	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|increase increase|nmod|production production|amod|END_ENTITY	Angiotensin_II enhances the increase in monocyte_chemoattractant_protein-1 production induced by tumor_necrosis_factor - -LCB- alpha -RCB- from 3T3-L1 preadipocytes .
19816747	0	Angiotensin_II	0,14	monocyte_chemoattractant_protein-1	43,77	Angiotensin II	monocyte chemoattractant protein-1	183	6347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Angiotensin_II regulates the expression of monocyte_chemoattractant_protein-1 in pancreatic_cancer cells .
27069537	0	Angiotensin_II	0,14	monocyte_chemoattractant_protein-1	186,220	Angiotensin II	monocyte chemoattractant protein-1	183	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|acute_aortic_dissection acute_aortic_dissection|acl|complicated complicated|advcl|modulating modulating|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II induces apoptosis of human pulmonary microvascular endothelial cells in acute_aortic_dissection complicated with lung_injury patients through modulating the expression of monocyte_chemoattractant_protein-1 .
9797345	0	Angiotensin_II	0,14	monocyte_chemoattractant_protein-1	23,57	Angiotensin II	monocyte chemoattractant protein-1	24179(Tax:10116)	24770(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces monocyte_chemoattractant_protein-1 gene expression in rat vascular smooth muscle cells .
1323434	0	Angiotensin_II	0,14	myelin_basic_protein	30,50	Angiotensin II	myelin basic protein	183	4155	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Angiotensin_II stimulates two myelin_basic_protein / microtubule-associated_protein_2 kinases in cultured vascular smooth muscle cells .
20446923	0	Angiotensin_II	0,14	myocardin	60,69	Angiotensin II	myocardin	24179(Tax:10116)	246297(Tax:10116)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|induction induction|nmod|END_ENTITY	Angiotensin_II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes .
26215453	0	Angiotensin_II	0,14	natriuretic_peptide_receptor-A	30,60	Angiotensin II	natriuretic peptide receptor-A	24179(Tax:10116)	24603(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II down-regulates natriuretic_peptide_receptor-A expression and guanylyl cyclase activity in H9c2 -LRB- 2-1 -RRB- cardiac_myoblast cells : Role of ROS and NF-kB .
10208867	0	Angiotensin_II	0,14	nuclear_factor-kappaB	66,87	Angiotensin II	nuclear factor-kappaB	183	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Angiotensin_II activates the proinflammatory transcription factor nuclear_factor-kappaB in human monocytes .
11108147	0	Angiotensin_II	0,14	nuclear_factor-kappaB	85,106	Angiotensin II	nuclear factor-kappaB	183	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|effects effects|nmod|factor factor|amod|END_ENTITY	Angiotensin_II induces gene transcription through cell-type-dependent effects on the nuclear_factor-kappaB -LRB- NF-kappaB -RRB- transcription factor .
16293568	0	Angiotensin_II	0,14	nuclear_factor-kappaB	68,89	Angiotensin II	nuclear factor-kappaB	183	4790	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|activation activation|amod|END_ENTITY	Angiotensin_II stimulates endothelial integrin_beta3 expression via nuclear_factor-kappaB activation .
19878671	0	Angiotensin_II	0,14	organic_anion_transporter_3	42,69	Angiotensin II	organic anion transporter 3	183	9376	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Angiotensin_II inhibits activity of human organic_anion_transporter_3 through activation of protein kinase Calpha : accelerating endocytosis of the transporter .
27051236	0	Angiotensin_II	0,14	p130Cas	25,32	Angiotensin II	p130Cas	11606(Tax:10090)	12927(Tax:10090)	Gene	Gene	Modulates|nsubj|START_ENTITY Modulates|dobj|END_ENTITY	Angiotensin_II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase .
11466560	0	Angiotensin_II	0,14	p27	23,26	Angiotensin II	p27	24179(Tax:10116)	83571(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces p27 -LRB- Kip1 -RRB- expression in renal tubules in vivo : role of reactive oxygen species .
8420973	0	Angiotensin_II	0,14	parathyroid_hormone-related_protein	25,60	Angiotensin II	parathyroid hormone-related protein	24179(Tax:10116)	24695(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II regulates parathyroid_hormone-related_protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms .
8166641	0	Angiotensin_II	0,14	phospholipase_A2	75,91	Angiotensin II	phospholipase A2	183	151056	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Angiotensin_II stimulates phosphorylation of high-molecular-mass cytosolic phospholipase_A2 in vascular smooth-muscle cells .
20500895	0	Angiotensin_II	0,14	placental_growth_factor	45,68	Angiotensin II	placental growth factor	183	5228	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II upregulates the expression of placental_growth_factor in human vascular endothelial cells and smooth muscle cells .
7957644	0	Angiotensin_II	0,14	placental_lactogen	29,47	Angiotensin II	placental lactogen	183	1443	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiotensin_II induces human placental_lactogen and pregnancy-specific_beta_1-glycoprotein secretion via an angiotensin AT1 receptor .
12021572	0	Angiotensin_II	0,14	plasminogen_activator_inhibitor-1	58,91	Angiotensin II	plasminogen activator inhibitor-1	183	5054	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Angiotensin_II and IV stimulate expression and release of plasminogen_activator_inhibitor-1 in cultured human coronary artery endothelial cells .
1537291	0	Angiotensin_II	0,14	plasminogen_activator_inhibitor-1	30,63	Angiotensin II	plasminogen activator inhibitor-1	24179(Tax:10116)	24617(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Angiotensin_II stimulation of plasminogen_activator_inhibitor-1 gene expression in astroglial cells from the brain .
19246637	0	Angiotensin_II	0,14	plasminogen_activator_inhibitor-1	29,62	Angiotensin II	plasminogen activator inhibitor-1	24179(Tax:10116)	24617(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiotensin_II induces renal plasminogen_activator_inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R. Angiotensin -LRB- Ang -RRB- II-induced fibrosis of the kidney is characterized by the enhanced expression of profibrotic and proinflammatory genes , including the serine protease inhibitor plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- .
7884001	0	Angiotensin_II	0,14	plasminogen_activator_inhibitor-1	43,76	Angiotensin II	plasminogen activator inhibitor-1	183	5054	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II regulates the expression of plasminogen_activator_inhibitor-1 in cultured endothelial cells .
8641204	0	Angiotensin_II	0,14	plasminogen_activator_inhibitor-1	29,62	Angiotensin II	plasminogen activator inhibitor-1	24179(Tax:10116)	24617(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Angiotensin_II regulation of plasminogen_activator_inhibitor-1 gene expression in neurons of normotensive and spontaneously hypertensive rat brains .
9241756	0	Angiotensin_II	0,14	plasminogen_activator_inhibitor-1	25,58	Angiotensin II	plasminogen activator inhibitor-1	24179(Tax:10116)	24617(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Angiotensin_II increases plasminogen_activator_inhibitor-1 and tissue factor mRNA expression without changing that of tissue type plasminogen activator or tissue_factor_pathway_inhibitor in cultured rat aortic endothelial cells .
18583239	0	Angiotensin_II	1,15	platelet-derived_growth_factor-B	27,59	Angiotensin II	platelet-derived growth factor-B	183	5155	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	-LSB- Angiotensin_II stimulates platelet-derived_growth_factor-B expression in hepatic stellate cells by activating EGR-1 -RSB- .
16569213	0	Angiotensin_II	0,14	platelet-derived_growth_factor_receptor-beta	69,113	Angiotensin II	platelet-derived growth factor receptor-beta	183	5159	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Angiotensin_II stimulates phosphorylation of an ectodomain-truncated platelet-derived_growth_factor_receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells .
11799102	0	Angiotensin_II	0,14	renin	58,63	Angiotensin II	renin	183	5972	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|humans humans|nmod|Aliskiren Aliskiren|compound|END_ENTITY	Angiotensin_II suppression in humans by the orally active renin inhibitor Aliskiren -LRB- SPP100 -RRB- : comparison with enalapril .
12010742	0	Angiotensin_II	0,14	renin	55,60	Angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	feedback|compound|START_ENTITY regulator|nsubj|feedback regulator|nmod|COX-2 COX-2|compound|END_ENTITY	Angiotensin_II feedback is a regulator of renocortical renin , COX-2 , and nNOS expression .
15238629	0	Angiotensin_II	0,14	renin	35,40	Angiotensin II	renin	183	5972	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Angiotensin_II activates the human renin promoter in an in vitro model : the role of c-Jun-N-terminal_kinase .
17376010	0	Angiotensin_II	0,14	renin	119,124	Angiotensin II	renin	183	5972	Gene	Gene	reactivation|compound|START_ENTITY reactivation|parataxis|inhibition inhibition|compound|END_ENTITY	Angiotensin_II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade : is oral renin inhibition the solution ?
21282553	0	Angiotensin_II	0,14	renin	26,31	Angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Angiotensin_II stimulates renin in inner medullary collecting duct cells via protein kinase C and independent of epithelial sodium channel and mineralocorticoid receptor activity .
2260680	0	Angiotensin_II	0,14	renin	25,30	Angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II regulates renin gene expression .
23266540	0	Angiotensin_II	0,14	renin	38,43	Angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|appos|independent independent|nmod|activity activity|compound|END_ENTITY	Angiotensin_II , independent of plasma renin activity , contributes to the hypertension of autonomic_failure .
474181	0	Angiotensin_II	0,14	renin	63,68	Angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|appos|relationship relationship|nmod|electrolytes electrolytes|compound|END_ENTITY	Angiotensin_II in primary hypertension , relationship to plasma renin activity , aldosterone and urinary electrolytes .
6170618	0	Angiotensin_II	0,14	renin	30,35	Angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|appos|END_ENTITY	Angiotensin_II in epitheloid -LRB- renin containing -RRB- cells of rat kidney .
6752538	0	Angiotensin_II	0,14	renin	48,53	Angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|acl|coexisting coexisting|nmod|END_ENTITY	Angiotensin_II immunoreactivity coexisting with renin in the human juxtaglomerular epithelioid cells .
7022457	0	Angiotensin_II	0,14	renin	46,51	Angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	coexists|nsubj|START_ENTITY coexists|nmod|END_ENTITY	Angiotensin_II immunoreactivity coexists with renin in the juxtaglomerular granular cells of the kidney .
846071	0	Angiotensin_II	0,14	renin	54,59	Angiotensin II	renin	183	5972	Gene	Gene	blockade|compound|START_ENTITY blockade|dep|interaction interaction|nmod|END_ENTITY	Angiotensin_II blockade in normal man : interaction of renin and sodium in maintaining blood pressure .
26126628	0	Angiotensin_II	0,14	secreted_frizzled-related_protein_5	25,60	Angiotensin II	secreted frizzled-related protein 5	24179(Tax:10116)	309377(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
17495027	0	Angiotensin_II	0,14	soluble_epoxide_hydrolase	28,53	Angiotensin II	soluble epoxide hydrolase	24179(Tax:10116)	65030(Tax:10116)	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Angiotensin_II up-regulates soluble_epoxide_hydrolase in vascular endothelium in vitro and in vivo .
14583433	0	Angiotensin_II	0,14	thrombospondin-1	23,39	Angiotensin II	thrombospondin-1	183	7057	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Angiotensin_II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK : a mechanism for activation of latent TGF-beta1 .
16675600	0	Angiotensin_II	0,14	toll-like_receptor_4	27,47	Angiotensin II	toll-like receptor 4	24179(Tax:10116)	21898(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	Angiotensin_II upregulates toll-like_receptor_4 on mesangial cells .
18992185	0	Angiotensin_II	1,15	toll-like_receptor_4	24,44	Angiotensin II	toll-like receptor 4	11606(Tax:10090)	21898(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	-LSB- Angiotensin_II induces toll-like_receptor_4 expression and myeloperoxidase activity in RAW264 .7 cells -RSB- .
19374881	0	Angiotensin_II	0,14	transforming_growth_factor-beta1	51,83	Angiotensin II	transforming growth factor-beta1	24179(Tax:10116)	59086(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Angiotensin_II increases collagen I expression via transforming_growth_factor-beta1 and extracellular_signal-regulated_kinase in cardiac fibroblasts .
8754788	0	Angiotensin_II	0,14	tyrosine_hydroxylase	29,49	Angiotensin II	tyrosine hydroxylase	24179(Tax:10116)	25085(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Angiotensin_II regulation of tyrosine_hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats .
11583973	0	Angiotensin_II	0,14	urokinase-type_plasminogen_activator	25,61	Angiotensin II	urokinase-type plasminogen activator	11606(Tax:10090)	5328	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Angiotensin_II increases urokinase-type_plasminogen_activator expression and induces aneurysm in the abdominal aorta of apolipoprotein_E-deficient mice .
21627650	0	Angiotensin_II	0,14	urotensin_II	24,36	Angiotensin II	urotensin II	24179(Tax:10116)	29180(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Angiotensin_II mediates urotensin_II expression by hypoxia in cultured cardiac fibroblast .
10484544	0	Angiotensin_II	0,14	vascular_cell_adhesion_molecule-1	23,56	Angiotensin II	vascular cell adhesion molecule-1	24179(Tax:10116)	25361(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Angiotensin_II induces vascular_cell_adhesion_molecule-1 expression in rat vasculature : A potential link between the renin-angiotensin system and atherosclerosis .
10712386	0	Angiotensin_II	0,14	vascular_cell_adhesion_molecule-1	38,71	Angiotensin II	vascular cell adhesion molecule-1	183	7412	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Angiotensin_II stimulates endothelial vascular_cell_adhesion_molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress .
12065685	0	Angiotensin_II	0,14	vascular_endothelial_growth_factor	50,84	Angiotensin II	vascular endothelial growth factor	11606(Tax:10090)	22339(Tax:10090)	Gene	Gene	effect|compound|START_ENTITY involves|nsubj|effect involves|dobj|pathways pathways|amod|END_ENTITY	Angiotensin_II angiogenic effect in vivo involves vascular_endothelial_growth_factor - and inflammation-related pathways .
12110003	0	Angiotensin_II	0,14	vascular_endothelial_growth_factor	29,63	Angiotensin II	vascular endothelial growth factor	24179(Tax:10116)	83785(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|Flt-1 Flt-1|compound|END_ENTITY	Angiotensin_II regulation of vascular_endothelial_growth_factor and receptors Flt-1 and KDR/Flk -1 in cyclosporine nephrotoxicity .
16115033	0	Angiotensin_II	0,14	vascular_endothelial_growth_factor	25,59	Angiotensin II	vascular endothelial growth factor	24179(Tax:10116)	83785(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Angiotensin_II regulates vascular_endothelial_growth_factor via hypoxia-inducible factor-1alpha induction and redox mechanisms in the kidney .
16595708	0	Angiotensin_II	0,14	vascular_endothelial_growth_factor	43,77	Angiotensin II	vascular endothelial growth factor	11606(Tax:10090)	22339(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|nmod|END_ENTITY	Angiotensin_II stimulates the synthesis of vascular_endothelial_growth_factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytes .
18026817	0	Angiotensin_II	0,14	vascular_endothelial_growth_factor	23,57	Angiotensin II	vascular endothelial growth factor	24179(Tax:10116)	83785(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiotensin_II induces vascular_endothelial_growth_factor in pancreatic_cancer cells through an angiotensin_II_type_1_receptor and ERK1/2 signaling .
18973754	0	Angiotensin_II	0,14	vascular_endothelial_growth_factor	23,57	Angiotensin II	vascular endothelial growth factor	183	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|compound|END_ENTITY	Angiotensin_II induces vascular_endothelial_growth_factor synthesis in mesenchymal stem cells .
7737726	0	Angiotensin_II	0,14	vascular_permeability_factor	25,53	Angiotensin II	vascular permeability factor	183	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Angiotensin_II increases vascular_permeability_factor gene expression by human vascular smooth muscle cells .
3143730	0	Angiotensin_II	0,14	vimentin	26,34	Angiotensin II	vimentin	24179(Tax:10116)	81818(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Angiotensin_II stimulates vimentin phosphorylation via a Ca2 + - dependent , protein kinase C-independent mechanism in cultured vascular smooth muscle cells .
11959040	0	Angiotensin_II_subtype_1	0,24	AT1	26,29	Angiotensin II subtype 1	AT1	24180(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Angiotensin_II_subtype_1 -LRB- AT1 -RRB- receptors contribute to ischemic_contracture and regulate chemomechanical energy transduction in isolated transgenic rat -LRB- alphaMHC-hAT1 -RRB- 594-17 hearts .
8794890	0	Angiotensin_II_type_1_receptor	0,30	Raf-1	47,52	Angiotensin II type 1 receptor	Raf-1	81638(Tax:10116)	24703(Tax:10116)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Angiotensin_II_type_1_receptor signals through Raf-1 by a protein_kinase_C-dependent , Ras-independent mechanism .
7734106	0	Angiotensin_I_converting_enzyme	0,31	ACE	33,36	Angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene polymorphism and essential hypertension in Japan .
2545579	0	Angiotensin_converting_enzyme	1,30	MK-0521	54,61	Angiotensin converting enzyme	MK-0521	610668(Tax:9615)	1476622(Tax:190192)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	-LSB- Angiotensin_converting_enzyme inhibitory activity of MK-0521 in vivo and antihypertensive effect of its single oral administration on blood pressure and effect on the renin-angiotensin system in 2-kidney Goldblatt hypertensive dogs -RSB- .
9383175	0	Angiotensin_converting_enzyme	0,29	bradykinin	84,94	Angiotensin converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY unmasks|nsubj|inhibition unmasks|dobj|effect effect|nmod|END_ENTITY	Angiotensin_converting_enzyme inhibition unmasks the sympathofacilitatory effect of bradykinin in human right atrium .
2698948	0	Angiotensin_converting_enzyme	0,29	renin	130,135	Angiotensin converting enzyme	renin	1636	5972	Gene	Gene	inhibition|amod|START_ENTITY lowers|nsubj|inhibition lowers|nmod|patients patients|nmod|autonomic_failure autonomic_failure|nmod|levels levels|compound|END_ENTITY	Angiotensin_converting_enzyme inhibition lowers blood pressure in patients with primary autonomic_failure independently of plasma renin levels and sympathetic nervous activity .
19224387	0	Angiotensin_converting_enzyme_2	0,31	ACE2	33,37	Angiotensin converting enzyme 2	ACE2	59272	59272	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Angiotensin_converting_enzyme_2 -LRB- ACE2 -RRB- activity in fetal calf serum : implications for cell culture research .
18320471	0	Angiotensin_subtype_1_receptor	69,99	IL-18	43,48	Angiotensin subtype 1 receptor	IL-18	24180(Tax:10116)	29197(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Mechanical stretch induced interleukin-18 -LRB- IL-18 -RRB- expression through Angiotensin_subtype_1_receptor -LRB- AT1R -RRB- and endothelin-1 in cardiomyocytes .
18320471	0	Angiotensin_subtype_1_receptor	69,99	interleukin-18	27,41	Angiotensin subtype 1 receptor	interleukin-18	24180(Tax:10116)	29197(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Mechanical stretch induced interleukin-18 -LRB- IL-18 -RRB- expression through Angiotensin_subtype_1_receptor -LRB- AT1R -RRB- and endothelin-1 in cardiomyocytes .
17206447	0	Angiotensin_type_1	0,18	TGF-beta1	76,85	Angiotensin type 1	TGF-beta1	24180(Tax:10116)	59086(Tax:10116)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	Angiotensin_type_1 -LRB- AT1 -RRB- and type 2 -LRB- AT2 -RRB- receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac_hypertrophy .
8833654	0	Angiotensinogen	0,15	angiotensin_II	35,49	Angiotensinogen	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
12805070	0	Angiotensinogen	0,15	angiotensinogen	42,57	Angiotensinogen	angiotensinogen	183	183	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Angiotensinogen gene polymorphism , plasma angiotensinogen , and risk of hypertension and ischemic_heart_disease : a meta-analysis .
8833654	0	Angiotensinogen	0,15	renin	147,152	Angiotensinogen	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY mediated|nsubjpass|activation mediated|nmod|factor factor|dep|mechanism mechanism|nmod|loop loop|compound|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
9781693	0	Angiotensinogen	0,15	renin	28,33	Angiotensinogen	renin	183	5972	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Angiotensinogen cleavage by renin : importance of a structurally constrained N-terminus .
9886872	0	Angiotensinogen	0,15	renin	105,110	Angiotensinogen	renin	183	5972	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|END_ENTITY	Angiotensinogen -LRB- M235T -RRB- and angiotensin-converting_enzyme -LRB- I/D -RRB- polymorphisms in association with plasma renin and prorenin levels .
22267746	0	Angptl4	21,28	Angiopoietin-like_4	0,19	Angptl4	Angiopoietin-like 4	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Angiopoietin-like_4 -LRB- Angptl4 -RRB- protein is a physiological mediator of intracellular lipolysis in murine adipocytes .
26069075	0	Angptl4	25,32	FIAF	34,38	Angptl4	FIAF	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
26069075	0	Angptl4	25,32	Interleukin-1b	0,14	Angptl4	Interleukin-1b	57875(Tax:10090)	16176(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|dobj|Expression	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
26069075	0	Angptl4	25,32	JNK	59,62	Angptl4	JNK	57875(Tax:10090)	26419(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Pathway Pathway|compound|END_ENTITY	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
21549101	5	Angptl4	878,885	LDLR	869,873	Angptl4	LDLR	57875(Tax:10090)	16835(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Fasting total cholesterol , VLDL-C , LDL-C , HDL-C and TG levels were decreased in LDLR -LRB- - / - -RRB- Angptl4 -LRB- - / - -RRB- mice compared with LDLR -LRB- - / - -RRB- Angptl4 -LRB- + / + -RRB- mice .
24397894	0	Angptl4	36,43	lipoprotein_lipase	14,32	Angptl4	lipoprotein lipase	51129	4023	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of lipoprotein_lipase by Angptl4 .
23718665	0	Angptl6	51,58	angiopoietin-related_growth_factor	15,49	Angptl6	angiopoietin-related growth factor	83854	83854	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of angiopoietin-related_growth_factor -LRB- Angptl6 -RRB- during pregnancy and in pre-eclampsia .
27062703	0	Anillin	18,25	ANLN	27,31	Anillin	ANLN	54443	54443	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Anillin -LRB- ANLN -RRB- is correlated with colorectal_cancer_progression and poor prognosis .
7506871	0	Anion_exchanger_1	0,17	AE1	72,75	Anion exchanger 1	AE1	6521	6521	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Anion_exchanger_1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus .
20576809	0	Anion_exchanger_1	0,17	nephrin	33,40	Anion exchanger 1	nephrin	20533(Tax:10090)	54631(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Anion_exchanger_1 interacts with nephrin in podocytes .
9587054	0	Anion_exchanger_2	0,17	erythrocyte_ankyrin	33,52	Anion exchanger 2	erythrocyte ankyrin	6522	286	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Anion_exchanger_2 -LRB- AE2 -RRB- binds to erythrocyte_ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells .
27086348	0	Ank	48,51	Interleukin-1b	0,14	Ank	Interleukin-1b	286	3553	Gene	Gene	Suppresses|dobj|START_ENTITY Suppresses|nsubj|END_ENTITY	Interleukin-1b Suppresses the Transporter Genes Ank and Ent1 Expression in Stromal Progenitor Cells Retaining Mineralization .
27086348	0	Ank	48,51	Interleukin-1b	0,14	Ank	Interleukin-1b	286	3553	Gene	Gene	Suppresses|dobj|START_ENTITY Suppresses|nsubj|END_ENTITY	Interleukin-1b Suppresses the Transporter Genes Ank and Ent1 Expression in Stromal Progenitor Cells Retaining Mineralization .
9458832	0	Ank3	36,40	ankyrin	27,34	Ank3	ankyrin	11735(Tax:10090)	11735(Tax:10090)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of epithelial ankyrin -LRB- Ank3 -RRB- spliceoforms in renal proximal and distal tubules .
23811403	0	Ankrd1	0,6	androgen_receptor	46,63	Ankrd1	androgen receptor	107765(Tax:10090)	11835(Tax:10090)	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Ankrd1 is a transcriptional repressor for the androgen_receptor that is downregulated by testosterone .
22328336	0	Ankrd17	0,7	RIG-I-like_receptor	29,48	Ankrd17	RIG-I-like receptor	26057	79132	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Ankrd17 positively regulates RIG-I-like_receptor -LRB- RLR -RRB- - mediated immune signaling .
24647531	0	Ankrd2	47,53	ZASP	0,4	Ankrd2	ZASP	26287	101927655	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ZASP interacts with the mechanosensing protein Ankrd2 and p53 in the signalling network of striated muscle .
17121810	0	Ankyrin	41,48	beta-Spectrin	0,13	Ankyrin	beta-Spectrin	43770(Tax:7227)	32746(Tax:7227)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS .
24395637	0	Ankyrin2	73,81	CK2	12,15	Ankyrin2	CK2	38863(Tax:7227)	48448(Tax:7227)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2 .
19118547	0	Ankyrin_repeat_domain_28	0,24	DOCK180	63,70	Ankyrin repeat domain 28	DOCK180	23243	1793	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Ankyrin_repeat_domain_28 -LRB- ANKRD28 -RRB- , a novel binding partner of DOCK180 , promotes cell migration by regulating focal adhesion formation .
19553536	0	Annexin-1	0,9	IL-6_and_TNF_via_glucocorticoid-induced_leucine_zipper	31,85	Annexin-1	IL-6 and TNF via glucocorticoid-induced leucine zipper	16952(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Annexin-1 regulates macrophage IL-6_and_TNF_via_glucocorticoid-induced_leucine_zipper .
24048896	0	Annexin-A1	0,10	IFN-b	34,39	Annexin-A1	IFN-b	16952(Tax:10090)	15977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Annexin-A1 regulates TLR-mediated IFN-b production through an interaction with TANK-binding_kinase_1 .
17114490	0	Annexin_1	0,9	IL-6	31,35	Annexin 1	IL-6	16952(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Annexin_1 negatively regulates IL-6 expression via effects on p38_MAPK and MAPK_phosphatase-1 .
20215502	0	Annexin_1	0,9	NF-kappaB	54,63	Annexin 1	NF-kappaB	301	4790	Gene	Gene	START_ENTITY|acl|induced induced|xcomp|END_ENTITY	Annexin_1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation : anticancer effects in vitro and in vivo .
21782780	0	Annexin_1	0,9	formyl_peptide_receptor	97,120	Annexin 1	formyl peptide receptor	301	2357	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Annexin_1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl_peptide_receptor 1 .
20947498	0	Annexin_2	0,9	AKT	61,64	Annexin 2	AKT	302	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	Annexin_2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity .
15256781	0	Annexin_5	0,9	thyrotropin_releasing_hormone	19,48	Annexin 5	thyrotropin releasing hormone	25673(Tax:10116)	25569(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Annexin_5 inhibits thyrotropin_releasing_hormone -LRB- TRH -RRB- stimulated prolactin release in the primary culture of rat anterior pituitary cells .
16460738	0	Annexin_A1	52,62	CCR10	32,37	Annexin A1	CCR10	301	2826	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	In vitro and in vivo studies on CCR10 regulation by Annexin_A1 .
22791338	0	Annexin_A1	0,10	cyclooxygenase_2	57,73	Annexin A1	cyclooxygenase 2	25380(Tax:10116)	29527(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Annexin_A1 modulates macula densa function by inhibiting cyclooxygenase_2 .
24118254	0	Annexin_A1	0,10	oxytocin	28,36	Annexin A1	oxytocin	301	5020	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Annexin_A1 complex mediates oxytocin vesicle transport .
26716413	0	Annexin_A2	61,71	CD147	0,5	Annexin A2	CD147	302	682	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CD147 regulates cancer migration via direct interaction with Annexin_A2 and DOCK3-b-catenin-WAVE2 signaling .
23792445	0	Annexin_A2	0,10	EGFR	28,32	Annexin A2	EGFR	302	1956	Gene	Gene	delays|amod|START_ENTITY END_ENTITY|nsubj|delays	Annexin_A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation .
18332131	0	Annexin_A2	0,10	Rab14	29,34	Annexin A2	Rab14	56611(Tax:10116)	94197(Tax:10116)	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Annexin_A2 interactions with Rab14 in alveolar type II cells .
20817051	0	Annexin_A2	18,28	VEGF	66,70	Annexin A2	VEGF	12306(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|cells cells|nmod|END_ENTITY	Hypoxia increases Annexin_A2 expression in osteoblastic cells via VEGF and ERK .
18008140	0	Annexin_A2	15,25	p53	29,32	Annexin A2	p53	302	7157	Gene	Gene	START_ENTITY|nmod|induced induced|compound|END_ENTITY	Involvement of Annexin_A2 in p53 induced apoptosis in lung_cancer .
15940368	0	Annexin_II	0,10	RANKL	22,27	Annexin II	RANKL	302	8600	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Annexin_II stimulates RANKL expression through MAPK .
25760235	0	Annexin_II	90,100	S100	40,44	Annexin II	S100	302	6285	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|Domain Domain|compound|END_ENTITY	Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin_II , Stratifin , and HSP27 .
17395158	0	Annexin_II	0,10	SHP2	20,24	Annexin II	SHP2	302	5781	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Annexin_II binds to SHP2 and this interaction is regulated by HSP70 levels .
22223826	0	Annexin_II	0,10	annexin_II_receptor	33,52	Annexin II	annexin II receptor	302	389289	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Annexin_II interactions with the annexin_II_receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment .
12431980	0	Annexin_II	13,23	insulin_receptor	42,58	Annexin II	insulin receptor	12306(Tax:10090)	16337(Tax:10090)	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|END_ENTITY	Secretion of Annexin_II via activation of insulin_receptor and insulin-like growth factor receptor .
26819684	0	Annexin_V	94,103	Bcl-2	110,115	Annexin V	Bcl-2	25673(Tax:10116)	24224(Tax:10116)	Gene	Gene	Levels|compound|START_ENTITY Levels|dep|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
19087127	0	Annexin_V	6,15	CD31	0,4	Annexin V	CD31	308	5175	Gene	Gene	+|compound|START_ENTITY microparticles|nsubj|+ +|parataxis|microparticles +|compound|END_ENTITY	CD31 + / Annexin_V + microparticles in healthy offsprings of patients with coronary_artery_disease .
21186238	0	Annexin_V	18,27	CD31	12,16	Annexin V	CD31	308	5175	Gene	Gene	+|compound|START_ENTITY microparticles|nsubj|+ +|parataxis|microparticles +|compound|END_ENTITY	Circulating CD31 + / Annexin_V + microparticles correlate with cardiovascular outcomes .
16914549	0	Annexin_V	0,9	beta5	10,15	Annexin V	beta5	308	10382	Gene	Gene	START_ENTITY|parataxis|regulate regulate|nsubj|interactions interactions|amod|END_ENTITY	Annexin_V / beta5 integrin interactions regulate apoptosis of growth plate chondrocytes .
26819684	0	Annexin_V	94,103	p53	105,108	Annexin V	p53	25673(Tax:10116)	301300(Tax:10116)	Gene	Gene	Levels|compound|START_ENTITY Levels|dep|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
23169617	0	Anoctamin_5	23,34	ANO5	41,45	Anoctamin 5	ANO5	203859	203859	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations in the Anoctamin_5 gene -LRB- ANO5 -RRB- associated with limb-girdle muscular_dystrophy 2L .
15548653	0	Anosmin-1	0,9	fibroblast_growth_factor_receptor_1	20,55	Anosmin-1	fibroblast growth factor receptor 1	3730	2260	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Anosmin-1 modulates fibroblast_growth_factor_receptor_1 signaling in human gonadotropin-releasing_hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism .
26034280	0	Anp32e	18,24	H2A.Z	33,38	Anp32e	H2A.Z	81611	3015	Gene	Gene	removes|nsubj|START_ENTITY removes|dobj|END_ENTITY	Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair .
26106152	0	Anp32e	58,64	H2A.Z	73,78	Anp32e	H2A.Z	81611	3015	Gene	Gene	removes|nsubj|START_ENTITY removes|dobj|END_ENTITY	Correction for Gursoy-Yuzugullu et al. , Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair .
11287128	0	Antithrombin	0,12	factor_Xa	72,81	Antithrombin	factor Xa	462	2159	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Antithrombin binding of low molecular weight heparins and inhibition of factor_Xa .
12195697	0	Antithrombin	65,77	thrombin	14,22	Antithrombin	thrombin	462	2147	Gene	Gene	I|compound|START_ENTITY formation|appos|I Inhibition|nmod|formation Inhibition|nmod|generation generation|compound|END_ENTITY	Inhibition of thrombin generation in plasma by fibrin formation -LRB- Antithrombin I -RRB- .
18292407	0	Antithrombin	0,12	thrombin	34,42	Antithrombin	thrombin	462	2147	Gene	Gene	deficiency|compound|START_ENTITY increases|nsubj|deficiency increases|dobj|activity activity|compound|END_ENTITY	Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass .
3360140	0	Antithrombin	0,12	thrombin	104,112	Antithrombin	thrombin	462	2147	Gene	Gene	Glasgow|compound|START_ENTITY Glasgow|dep|variant variant|nmod|affinity affinity|nmod|activity activity|compound|END_ENTITY	Antithrombin Glasgow , 393_Arg_to_His : a P1 reactive site variant with increased heparin affinity but no thrombin inhibitory activity .
18088351	0	Antithrombin	0,12	tumor_necrosis_factor-alpha	49,76	Antithrombin	tumor necrosis factor-alpha	462	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Antithrombin inhibits lipopolysaccharide-induced tumor_necrosis_factor-alpha production by monocytes in vitro through inhibition of Egr-1 expression .
11277613	0	Antithrombin_III	0,16	inducible_nitric_oxide_synthase	26,57	Antithrombin III	inducible nitric oxide synthase	462	4843	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Antithrombin_III enhances inducible_nitric_oxide_synthase gene expression in vascular smooth muscle cells .
1926061	0	Antithrombin_III	0,16	thrombin	41,49	Antithrombin III	thrombin	540261(Tax:9913)	280685(Tax:9913)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	Antithrombin_III modulates the effect of thrombin on the metabolism of glycosaminoglycans in cultured endothelial cells .
12645926	0	Antizyme	0,8	sex-lethal	24,34	Antizyme	sex-lethal	36307(Tax:7227)	3772180(Tax:7227)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin_B .
19325895	0	Anx2	0,4	Gag	26,29	Anx2	Gag	302	155030(Tax:11676)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Anx2 interacts with HIV-1 Gag at phosphatidylinositol -LRB- 4,5 -RRB- bisphosphate-containing lipid rafts and increases viral production in 293T cells .
24239898	0	Anxa2	31,36	P-glycoprotein	0,14	Anxa2	P-glycoprotein	302	5243	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	P-glycoprotein associates with Anxa2 and promotes invasion in multidrug resistant breast_cancer cells .
26307676	0	Anxa2	0,5	STAT3	15,20	Anxa2	STAT3	302	6774	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast_cancer cells .
12644691	0	Aox1	38,42	alternative_oxidase	18,37	Aox1	alternative oxidase	5720157(Tax:3055)	5728961(Tax:3055)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Regulation of the alternative_oxidase Aox1 gene in Chlamydomonas_reinhardtii .
21030269	0	Ap-1	21,25	Angiotensin_II	102,116	Ap-1	Angiotensin II	3725	183	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|cells cells|acl|exposed exposed|nmod|END_ENTITY	Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothelial cells exposed to Angiotensin_II .
27090238	0	Ap1g1	52,57	gamma-1_adaptin	30,45	Ap1g1	gamma-1 adaptin	11765(Tax:10090)	11765(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A hypomorphic mutation of the gamma-1_adaptin gene -LRB- Ap1g1 -RRB- causes inner ear , retina , thyroid , and testes_abnormalities in mice .
9931340	0	Ap3b1	25,30	beta3A	4,10	Ap3b1	beta3A	11774(Tax:10090)	11774(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The beta3A subunit gene -LRB- Ap3b1 -RRB- of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl , a model for Hermansky-Pudlak_syndrome and night_blindness .
26290023	0	Apa1	1,5	VDR	6,9	Apa1	VDR	57862	7421	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Apa1 VDR polymorphism and osteoporosis risk in postmenopausal mexican women -RSB- .
26290023	0	Apa1	1,5	VDR	6,9	Apa1	VDR	57862	7421	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Apa1 VDR polymorphism and osteoporosis risk in postmenopausal mexican women -RSB- .
23207240	0	Apaf-1	22,28	Bcl-2	95,100	Apaf-1	Bcl-2	317	596	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins .
12963020	0	Apaf-1	70,76	Bcl-XL	20,26	Apaf-1	Bcl-XL	317	598	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|region region|amod|END_ENTITY	Identification of a Bcl-XL binding region within the ATPase domain of Apaf-1 .
9539746	0	Apaf-1	22,28	Bcl-XL	0,6	Apaf-1	Bcl-XL	317	598	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation .
10773825	0	Apaf-1	40,46	Bcl-xL	0,6	Apaf-1	Bcl-xL	317	598	Gene	Gene	function|nmod|START_ENTITY inhibit|dobj|function inhibit|nsubj|END_ENTITY	Bcl-xL does not inhibit the function of Apaf-1 .
14617792	0	Apaf-1	94,100	Bcl-xL	43,49	Apaf-1	Bcl-xL	317	598	Gene	Gene	factor-1|dep|START_ENTITY expression|amod|factor-1 activating|dobj|expression activating|nsubj|END_ENTITY	Rituximab -LRB- anti-CD20 -RRB- selectively modifies Bcl-xL and apoptosis protease activating factor-1 -LRB- Apaf-1 -RRB- expression and sensitizes human non-Hodgkin 's _ lymphoma B cell lines to paclitaxel-induced apoptosis .
9878060	0	Apaf-1	62,68	Boo	0,3	Apaf-1	Boo	317	10017	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Boo , a novel negative regulator of cell death , interacts with Apaf-1 .
10364241	0	Apaf-1	50,56	Cytochrome_c	0,12	Apaf-1	Cytochrome c	317	54205	Gene	Gene	oligomerization|nmod|START_ENTITY oligomerization|amod|END_ENTITY	Cytochrome_c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation .
10940292	0	Apaf-1	77,83	Cytochrome_c	0,12	Apaf-1	Cytochrome c	317	54205	Gene	Gene	nucleotide|amod|START_ENTITY inducing|dobj|nucleotide promotes|advcl|inducing promotes|nsubj|END_ENTITY	Cytochrome_c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 .
9390557	0	Apaf-1	45,51	Cytochrome_c	0,12	Apaf-1	Cytochrome c	317	54205	Gene	Gene	formation|nmod|START_ENTITY formation|amod|END_ENTITY	Cytochrome_c and dATP-dependent formation of Apaf-1 / caspase-9 complex initiates an apoptotic protease cascade .
16397188	0	Apaf-1	100,106	Hsp70	179,184	Apaf-1	Hsp70	11783(Tax:10090)	15511(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Reduction of caspase-8_and _ -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic _ injury in mice overexpressing Hsp70 .
25586265	0	Apaf-1	94,100	MicroRNA-221	0,12	Apaf-1	MicroRNA-221	317	407006	Gene	Gene	accelerates|nmod|START_ENTITY accelerates|nsubj|END_ENTITY	MicroRNA-221 accelerates the proliferation of laryngeal_cancer cell line Hep-2 by suppressing Apaf-1 .
23207240	0	Apaf-1	22,28	PSAP	0,4	Apaf-1	PSAP	317	23787	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins .
10342853	0	Apaf-1	94,100	apoptotic_protease-activating_factor-1	54,92	Apaf-1	apoptotic protease-activating factor-1	11783(Tax:10090)	11783(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Localization , regulation and possible consequences of apoptotic_protease-activating_factor-1 -LRB- Apaf-1 -RRB- expression in granulosa cells of the mouse ovary .
18197610	0	Apaf-1	78,84	apoptotic_protease-activating_factor_1	38,76	Apaf-1	apoptotic protease-activating factor 1	78963(Tax:10116)	78963(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Modulation of cellular apoptosis with apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- inhibitors .
10940292	0	Apaf-1	77,83	caspase-9	22,31	Apaf-1	caspase-9	317	842	Gene	Gene	nucleotide|amod|START_ENTITY inducing|dobj|nucleotide promotes|advcl|inducing promotes|dobj|activation activation|amod|END_ENTITY	Cytochrome_c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 .
11753565	0	Apaf-1	17,23	caspase-9	68,77	Apaf-1	caspase-9	78963(Tax:10116)	58918(Tax:10116)	Gene	Gene	Formation|nmod|START_ENTITY Formation|parataxis|precedes precedes|dobj|activation activation|nmod|END_ENTITY	Formation of the Apaf-1 / cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal_death .
11904389	0	Apaf-1	56,62	caspase-9	34,43	Apaf-1	caspase-9	317	842	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Oligomerization and activation of caspase-9 , induced by Apaf-1 CARD .
12506111	0	Apaf-1	18,24	caspase-9	25,34	Apaf-1	caspase-9	317	842	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|apoptosome apoptosome|amod|END_ENTITY	Regulation of the Apaf-1 / caspase-9 apoptosome by caspase-3 and XIAP .
12605597	0	Apaf-1	45,51	caspase-9	52,61	Apaf-1	caspase-9	317	842	Gene	Gene	START_ENTITY|dep|apoptosome apoptosome|amod|END_ENTITY	Nitric_oxide donors inhibit formation of the Apaf-1 / caspase-9 apoptosome and activation of caspases .
14993223	0	Apaf-1	133,139	caspase-9	140,149	Apaf-1	caspase-9	317	842	Gene	Gene	START_ENTITY|dep|complex complex|dep|apoptosome apoptosome|amod|END_ENTITY	Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1 / caspase-9 apoptosome complex .
15253891	0	Apaf-1	58,64	caspase-9	65,74	Apaf-1	caspase-9	78963(Tax:10116)	58918(Tax:10116)	Gene	Gene	apoptosome|compound|START_ENTITY apoptosome|amod|END_ENTITY	Taurine inhibits apoptosis by preventing formation of the Apaf-1 / caspase-9 apoptosome .
15703181	0	Apaf-1	51,57	caspase-9	27,36	Apaf-1	caspase-9	317	842	Gene	Gene	downstream|compound|START_ENTITY kinase|nmod|downstream kinase|dobj|activation activation|amod|END_ENTITY	Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome_c .
19238172	0	Apaf-1	103,109	caspase-9	26,35	Apaf-1	caspase-9	317	842	Gene	Gene	facilitates|nmod|START_ENTITY facilitates|nsubj|modification modification|nmod|END_ENTITY	Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1 .
21659556	0	Apaf-1	131,137	caspase-9	103,112	Apaf-1	caspase-9	417926(Tax:9031)	426970(Tax:9031)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine : activation of caspase-9 in the absence of Apaf-1 .
25313070	0	Apaf-1	54,60	caspase-9	26,35	Apaf-1	caspase-9	317	842	Gene	Gene	apoptosome|compound|START_ENTITY determinants|nmod|apoptosome determinants|nmod|activation activation|amod|END_ENTITY	Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome .
9390557	0	Apaf-1	45,51	caspase-9	52,61	Apaf-1	caspase-9	317	842	Gene	Gene	formation|nmod|START_ENTITY formation|dep|initiates initiates|amod|END_ENTITY	Cytochrome_c and dATP-dependent formation of Apaf-1 / caspase-9 complex initiates an apoptotic protease cascade .
11003619	0	Apaf-1	127,133	cytochrome_c	83,95	Apaf-1	cytochrome c	78963(Tax:10116)	54205	Gene	Gene	complex|amod|START_ENTITY apoptosis|nmod|complex apoptosis|nmod|cells cells|nmod|release release|amod|END_ENTITY	Transforming_growth_factor-beta -LRB- 1 -RRB- induces apoptosis in rat FaO hepatoma cells via cytochrome_c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex .
11516099	0	Apaf-1	187,193	cytochrome_c	89,101	Apaf-1	cytochrome c	317	54205	Gene	Gene	formation|nmod|START_ENTITY accompanied|nmod|formation release|acl|accompanied release|amod|END_ENTITY	Proteasome inhibitor-induced apoptosis of B-chronic_lymphocytic_leukaemia cells involves cytochrome_c release and caspase activation , accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex .
15703181	0	Apaf-1	51,57	cytochrome_c	72,84	Apaf-1	cytochrome c	317	54205	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome_c .
16650876	0	Apaf-1	71,77	cytochrome_c	58,70	Apaf-1	cytochrome c	317	54205	Gene	Gene	ratio|compound|START_ENTITY ratio|dep|END_ENTITY	A mathematical model for apoptosome assembly : the optimal cytochrome_c / Apaf-1 ratio .
26014357	0	Apaf-1	67,73	cytochrome_c	32,44	Apaf-1	cytochrome c	317	54205	Gene	Gene	Modeling|nmod|START_ENTITY Modeling|nmod|END_ENTITY	Modeling of interaction between cytochrome_c and the WD domains of Apaf-1 : bifurcated salt bridges underlying apoptosome assembly .
26543158	0	Apaf-1	95,101	cytochrome_c	49,61	Apaf-1	cytochrome c	317	54205	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Atomic structure of the apoptosome : mechanism of cytochrome_c - and dATP-mediated activation of Apaf-1 .
11423996	0	Apaf-1	83,89	p53	45,48	Apaf-1	p53	317	7157	Gene	Gene	activation|nmod|START_ENTITY analysis|dep|activation analysis|nmod|genes genes|acl|involved involved|nmod|apoptosis apoptosis|nummod|END_ENTITY	DNA microarray analysis of genes involved in p53 mediated apoptosis : activation of Apaf-1 .
12883670	0	Apaf-1	30,36	p53	51,54	Apaf-1	p53	11783(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Tissue-specific regulation of Apaf-1 expression by p53 .
16021178	0	Apaf-1	5,11	p53	0,3	Apaf-1	p53	317	7157	Gene	Gene	-9|amod|START_ENTITY END_ENTITY|appos|-9	p53 , Apaf-1 , caspase-3 , _ and _ -9 are dispensable for Cdk5 activation during cell death .
9753320	0	Apaf1	0,5	CED-4	7,12	Apaf1	CED-4	317	317	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Apaf1 -LRB- CED-4 homolog -RRB- regulates programmed cell death in mammalian development .
20966962	0	Apaf1	41,46	Ku70/86	23,30	Apaf1	Ku70/86	317	2547;7520	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage .
17361096	0	Apaf1	0,5	p53	109,112	Apaf1	p53	317	7157	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|mutation mutation|compound|END_ENTITY	Apaf1 in chronic_myelogenous_leukemia -LRB- CML -RRB- progression : reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis .
17361096	0	Apaf1	65,70	p53	109,112	Apaf1	p53	317	7157	Gene	Gene	expression|amod|START_ENTITY progression|dep|expression Apaf1|nmod|progression correlated|nsubjpass|Apaf1 correlated|nmod|mutation mutation|compound|END_ENTITY	Apaf1 in chronic_myelogenous_leukemia -LRB- CML -RRB- progression : reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis .
22334068	0	Apak	0,4	p53	19,22	Apak	p53	147923	7157	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis .
10213222	0	Apc	131,134	Min	135,138	Apc	Min	11789(Tax:10090)	11789(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Evaluation of 5-aminosalicylic_acid -LRB- 5-ASA -RRB- for cancer chemoprevention : lack of efficacy against nascent adenomatous_polyps in the Apc -LRB- Min -RRB- mouse .
10602475	0	Apc	73,76	beta-catenin	27,39	Apc	beta-catenin	11789(Tax:10090)	12387(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY change|nmod|mice marks|dobj|change marks|nsubj|expression expression|nmod|END_ENTITY	Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice , but not all lesions arising in Msh2 deficient mice .
10992298	0	Apc	8,11	beta-catenin	73,85	Apc	beta-catenin	11789(Tax:10090)	12387(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY selected|nsubjpass|mutations selected|nmod|capacity capacity|acl|inactivate inactivate|dobj|activity activity|amod|END_ENTITY	Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity .
15563600	0	Apc	29,32	beta-catenin	51,63	Apc	beta-catenin	11789(Tax:10090)	12387(Tax:10090)	Gene	Gene	disruption|nmod|START_ENTITY activates|nsubj|disruption activates|dobj|signaling signaling|amod|END_ENTITY	Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular_carcinomas .
19248780	0	Apc	4,7	beta-catenin	81,93	Apc	beta-catenin	11789(Tax:10090)	12387(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY develops|nsubj|mouse develops|dobj|polyposis polyposis|acl|associated associated|nmod|expression expression|amod|END_ENTITY	The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression .
24177423	0	Apelin	0,6	ACE2	34,38	Apelin	ACE2	30878(Tax:10090)	70008(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Apelin is a positive regulator of ACE2 in failing hearts .
10525157	0	Apelin	0,6	APJ	50,53	Apelin	APJ	58812(Tax:10116)	83518(Tax:10116)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Apelin , the natural ligand of the orphan receptor APJ , is abundantly secreted in the colostrum .
11090199	0	Apelin	0,6	APJ	70,73	Apelin	APJ	8862	187	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Apelin , the natural ligand of the orphan seven-transmembrane receptor APJ , inhibits human_immunodeficiency_virus_type_1 entry .
12215493	0	Apelin	0,6	APJ	59,62	Apelin	APJ	58812(Tax:10116)	83518(Tax:10116)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Apelin , the novel endogenous ligand of the orphan receptor APJ , regulates cardiac contractility .
16750822	0	Apelin	0,6	APJ	67,70	Apelin	APJ	30878(Tax:10090)	23796(Tax:10090)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|receptor receptor|appos|END_ENTITY	Apelin , the ligand for the endothelial G-protein-coupled receptor , APJ , is a potent angiogenic factor required for normal vascular development of the frog embryo .
22834038	0	Apelin	27,33	APJ	35,38	Apelin	APJ	8862	187	Gene	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Functional Agonists of the Apelin -LRB- APJ -RRB- Receptor The recently discovered apelin receptor -LRB- APJ , AGTRL-1 , APLNR -RRB- system has emerged as a critical mediator of cardiovascular homeostasis involved in the pathogenesis of hypertension , heart_failure , atherosclerosis and other cardiovascular_diseases .
23658961	0	Apelin	30,36	APJ	38,41	Apelin	APJ	8862	187	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Functional antagonists of the Apelin -LRB- APJ -RRB- receptor The recently discovered apelin receptor -LRB- APJ , AGTRL-1 , APLNR -RRB- system has emerged as a critical mediator of cardiovascular homeostasis and is involved in the pathogenesis of hypertension , heart_failure , atherosclerosis , and other cardiovascular_diseases .
25748499	0	Apelin	0,6	TGF-b1	57,63	Apelin	TGF-b1	58812(Tax:10116)	59086(Tax:10116)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Apelin protects against acute_renal_injury by inhibiting TGF-b1 .
16556853	0	Apelin	0,6	myosin_light_chain	18,36	Apelin	myosin light chain	30878(Tax:10090)	170790(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Apelin stimulates myosin_light_chain phosphorylation in vascular smooth muscle cells .
15385434	0	Apelin	0,6	p70_S6_kinase	25,38	Apelin	p70 S6 kinase	8862	6198	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Apelin -LRB- 65-77 -RRB- activates p70_S6_kinase and is mitogenic for umbilical endothelial cells .
16407410	0	Apg-2	23,28	ZO-1	65,69	Apg-2	ZO-1	3308	7082	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB .
11060023	0	Apg8p	36,41	LC3	0,3	Apg8p	LC3	852200(Tax:4932)	84557	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	LC3 , a mammalian homologue of yeast Apg8p , is localized in autophagosome membranes after processing .
7595225	0	Apo-1	104,109	Apo-1	22,27	Apo-1	Apo-1	355	355	Gene	Gene	apoptosis|nmod|START_ENTITY END_ENTITY|dep|apoptosis	CD40 ligation induces Apo-1 / Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1 / Fas pathway .
7595225	0	Apo-1	22,27	Apo-1	104,109	Apo-1	Apo-1	355	355	Gene	Gene	START_ENTITY|dep|apoptosis apoptosis|nmod|END_ENTITY	CD40 ligation induces Apo-1 / Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1 / Fas pathway .
15061197	0	Apo-1	26,31	CD178	49,54	Apo-1	CD178	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Alterations in Fas -LRB- CD_95 / Apo-1 -RRB- and Fas_ligand -LRB- CD178 -RRB- expression in acute_promyelocytic_leukemia during treatment with ATRA .
9163609	0	Apo-1	14,19	CD95	25,29	Apo-1	CD95	355	355	Gene	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	Expression of Apo-1 / Fas -LRB- CD95 -RRB- , Bcl-2 , Bax and Bcl-x in myeloma cell lines : relationship between responsiveness to anti-Fas mab and p53 functional status .
9393960	0	Apo-1	89,94	CD95	100,104	Apo-1	CD95	355	355	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of polymorphisms in the promoter region of the human Apo-1 / Fas -LRB- CD95 -RRB- gene .
10946322	0	Apo-2_ligand	74,86	TNF-related_apoptosis-inducing_ligand	36,73	Apo-2 ligand	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Adenoviral-mediated transfer of the TNF-related_apoptosis-inducing_ligand / Apo-2_ligand gene induces tumor cell apoptosis .
18701171	0	Apo-B	38,43	apolipoprotein-B	20,36	Apo-B	apolipoprotein-B	338	338	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The significance of apolipoprotein-B -LRB- Apo-B -RRB- in the elderly as a predictive factor of cardio-cerebrovascular_complications .
12907654	0	Apo2_ligand	87,98	tumor_necrosis_factor-related_apoptosis-inducing_ligand	99,154	Apo2 ligand	tumor necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	induction|nmod|START_ENTITY induction|parataxis|END_ENTITY	Apoptosis induction in prostate_cancer cells and xenografts by combined treatment with Apo2_ligand / tumor_necrosis_factor-related_apoptosis-inducing_ligand and CPT-11 .
15109267	0	ApoA-I	62,68	ApoCIII	79,86	ApoA-I	ApoCIII	11806(Tax:10090)	11814(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Contribution of the hormone-response elements of the proximal ApoA-I promoter , ApoCIII enhancer , and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic_mice .
3142880	0	ApoA-I	50,56	apolipoprotein_A-I	30,48	ApoA-I	apolipoprotein A-I	335	335	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Tissue-specific expression of apolipoprotein_A-I -LRB- ApoA-I -RRB- is regulated by the 5 ' - flanking region of the human ApoA-I gene .
14729860	0	ApoA-II	0,7	SR-BI	74,79	ApoA-II	SR-BI	11807(Tax:10090)	20778(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36 .
25281277	0	ApoA1	132,137	ABCA1	119,124	ApoA1	ABCA1	335	19	Gene	Gene	Mutations|compound|START_ENTITY Mutations|compound|END_ENTITY	Treatment of Low HDL-C Subjects with the CETP Modulator Dalcetrapib Increases Plasma Campesterol Only in Those Without ABCA1 and/or ApoA1 Mutations .
25569858	0	ApoA1	19,24	ABCA1	50,55	ApoA1	ABCA1	335	19	Gene	Gene	START_ENTITY|nmod|Interaction Interaction|nmod|END_ENTITY	Will Lipidation of ApoA1 through Interaction with ABCA1 at the Intestinal Level Affect the Protective Functions of HDL ?
9284903	0	ApoB	87,91	apolipoprotein_B	69,85	ApoB	apolipoprotein B	338	338	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Normal intestinal dietary fat and cholesterol absorption , intestinal apolipoprotein_B -LRB- ApoB -RRB- mRNA levels , and ApoB-48 synthesis in a hypobetalipoproteinemic kindred without any ApoB truncation .
18272520	0	ApoB	14,18	low_density_lipoprotein_receptor	36,68	ApoB	low density lipoprotein receptor	238055(Tax:10090)	16835(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Regulation of ApoB secretion by the low_density_lipoprotein_receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB .
24173238	0	ApoB100	48,55	GLT8D2	20,26	ApoB100	GLT8D2	338	83468	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glycosyltransferase GLT8D2 positively regulates ApoB100 protein expression in hepatocytes .
12883330	0	ApoC-I	35,41	THP-1	69,74	ApoC-I	THP-1	341	2736	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Effect of atorvastatin on ApoE and ApoC-I synthesis and secretion by THP-1 macrophages .
2307668	0	ApoC-II	12,19	lipoprotein_lipase	34,52	ApoC-II	lipoprotein lipase	344	4023	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Lipoprotein ApoC-II activation of lipoprotein_lipase .
20889132	0	ApoC3	22,27	PGC-1b	42,48	ApoC3	PGC-1b	11814(Tax:10090)	170826(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of hepatic ApoC3 expression by PGC-1b mediates hypolipidemic effect of nicotinic_acid .
15109267	0	ApoCIII	79,86	ApoA-I	62,68	ApoCIII	ApoA-I	11814(Tax:10090)	11806(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Contribution of the hormone-response elements of the proximal ApoA-I promoter , ApoCIII enhancer , and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic_mice .
25255477	0	ApoCIII	14,21	PCSK9	32,37	ApoCIII	PCSK9	345	255738	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition of ApoCIII : the next PCSK9 ?
12551940	0	ApoE	19,23	ApoE	70,74	ApoE	ApoE	11816(Tax:10090)	11816(Tax:10090)	Gene	Gene	effective|nsubj|START_ENTITY effective|nmod|END_ENTITY	Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance .
12551940	0	ApoE	70,74	ApoE	19,23	ApoE	ApoE	11816(Tax:10090)	11816(Tax:10090)	Gene	Gene	effective|nmod|START_ENTITY effective|nsubj|END_ENTITY	Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance .
27033052	0	ApoE	33,37	Apolipoprotein_E	15,31	ApoE	Apolipoprotein E	348	348	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of Apolipoprotein_E -LRB- ApoE -RRB- polymorphism with Alzheimer 's _ Disease in Chinese population .
17669410	0	ApoE	61,65	C-reactive_protein	7,25	ApoE	C-reactive protein	11816(Tax:10090)	12944(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Native C-reactive_protein induces endothelial_dysfunction in ApoE - / - mice : implications for iNOS and reactive oxygen species .
26606905	0	ApoE	112,116	DNMT1	103,108	ApoE	DNMT1	11816(Tax:10090)	13433(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE -LRB- - / - -RRB- mice .
26832342	0	ApoE	112,116	GLP-1	88,93	ApoE	GLP-1	11816(Tax:10090)	14526(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Alleviation of high-fat diet-induced atherosclerosis and glucose_intolerance by a novel GLP-1 fusion protein in ApoE -LRB- - / - -RRB- mice .
20197419	0	ApoE	143,147	LDL_receptor	25,37	ApoE	LDL receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY shared|nmod|mice perturbations|acl:relcl|shared reveals|dobj|perturbations fed|ccomp|reveals fed|nsubj|study study|nmod|mouse mouse|compound|END_ENTITY	Metabolomic study of the LDL_receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice .
22150227	0	ApoE	76,80	LDL_receptor	86,98	ApoE	LDL receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	lessons|nmod|START_ENTITY lessons|parataxis|model model|dep|double double|nmod:npmod|END_ENTITY	Mixed testicular_atrophy related to atherosclerosis : first lessons from the ApoE -LRB- - / - -RRB- / LDL_receptor -LRB- - / - -RRB- double knockout mouse model .
3958613	0	ApoE	0,4	LDL_receptor	96,108	ApoE	LDL receptor	348	3949	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|the the|nmod|lipoproteins lipoproteins|nmod|END_ENTITY	ApoE is necessary and sufficient for the binding of large triglyceride-rich lipoproteins to the LDL_receptor ; apoB is unnecessary .
15795933	0	ApoE	93,97	PLTP	80,84	ApoE	PLTP	348	5360	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Reduced CSF PLTP activity in Alzheimer 's _ disease and other neurologic_diseases ; PLTP induces ApoE secretion in primary human astrocytes in vitro .
16185081	0	ApoE	72,76	SR-BI	0,5	ApoE	SR-BI	348	949	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE .
26322923	0	ApoE	74,78	SR-BI	97,102	ApoE	SR-BI	11816(Tax:10090)	20778(Tax:10090)	Gene	Gene	Deficient|compound|START_ENTITY Deficient|nmod|Expression Expression|compound|END_ENTITY	Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial_Infarction Caused by Coronary_Atherosclerosis .
25677604	0	ApoE	179,183	Tissue_Factor_Pathway_Inhibitor	20,51	ApoE	Tissue Factor Pathway Inhibitor	348	7035	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Human Tissue_Factor_Pathway_Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage_Migration_Inhibitory_Factor and Attenuates_Atherosclerosis in ApoE - / - Mice .
10327190	0	ApoE	31,35	apolipoprotein_E	13,29	ApoE	apolipoprotein E	348	348	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Synthesis of apolipoprotein_E -LRB- ApoE -RRB- mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE .
11140944	0	ApoE	102,106	apolipoprotein_E	84,100	ApoE	apolipoprotein E	348	348	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Complex adaptive systems and human health : the influence of common genotypes of the apolipoprotein_E -LRB- ApoE -RRB- gene polymorphism and age on the relational order within a field of lipid metabolism traits .
16687490	0	ApoE	44,48	apolipoprotein_E	26,42	ApoE	apolipoprotein E	11816(Tax:10090)	11816(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Profile and regulation of apolipoprotein_E -LRB- ApoE -RRB- expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus .
18987181	0	ApoE	28,32	apolipoprotein_E	10,26	ApoE	apolipoprotein E	11816(Tax:10090)	11816(Tax:10090)	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of apolipoprotein_E -LRB- ApoE -RRB- polymorphism on brain ApoE levels .
21388338	0	ApoE	32,36	apolipoprotein_E	14,30	ApoE	apolipoprotein E	348	348	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of apolipoprotein_E -LRB- ApoE -RRB- genotype on biomarkers of amyloidogenesis , tau pathology and neurodegeneration in Alzheimer 's _ disease .
25890021	0	ApoE	33,37	apolipoprotein_E	15,31	ApoE	apolipoprotein E	348	348	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of apolipoprotein_E -LRB- ApoE -RRB- polymorphisms with risk of primary hyperuricemia in Uygur men , Xinjiang , China .
7251821	0	ApoE	38,42	apolipoprotein_E	20,36	ApoE	apolipoprotein E	348	348	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of apolipoprotein_E -LRB- ApoE -RRB- apoprotein levels in the various ApoE phenotypes .
9524247	0	ApoE	48,52	apolipoprotein_E	30,46	ApoE	apolipoprotein E	101112253	101112253	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the sheep apolipoprotein_E -LRB- ApoE -RRB- gene and allelic variations of the ApoE gene in scrapie Suffolk sheep .
20353975	0	ApoER2	18,24	LRP8	12,16	ApoER2	LRP8	7804	7804	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of LRP8 -LRB- ApoER2 ' -RRB- in the pathophysiology of the antiphospholipid_syndrome .
18946489	0	ApoER2	26,32	Thrombospondin-1	0,16	ApoER2	Thrombospondin-1	7804	7057	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Thrombospondin-1 binds to ApoER2 and VLDL_receptor and functions in postnatal neuronal migration .
25726912	0	ApoF	52,56	apolipoprotein_F	34,50	ApoF	apolipoprotein F	319	319	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the apolipoprotein_F -LRB- ApoF -RRB- gene by ETS and C/EBPa in hepatoma cells .
25726912	0	ApoF	52,56	apolipoprotein_F	34,50	ApoF	apolipoprotein F	319	319	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the apolipoprotein_F -LRB- ApoF -RRB- gene by ETS and C/EBPa in hepatoma cells .
25076422	0	ApoJ	18,22	clusterin	7,16	ApoJ	clusterin	1191	1191	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Plasma clusterin -LRB- ApoJ -RRB- levels are associated with adiposity and systemic_inflammation .
26057873	0	ApoM	0,4	ICAM-1	44,50	ApoM	ICAM-1	55937	3383	Gene	Gene	START_ENTITY|dobj|Expression Expression|nmod|END_ENTITY	ApoM Suppresses TNF-a-Induced Expression of ICAM-1 and VCAM-1 Through Inhibiting the Activity of NF-kB .
18157393	0	Apo_A-I	6,13	Apo_B	0,5	Apo A-I	Apo B	335	338	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|dep|ratio	Apo_B / Apo_A-I ratio in central and peripheral arterial_diseases .
24701475	0	Apo_A-I	6,13	Apo_B	0,5	Apo A-I	Apo B	335	338	Gene	Gene	Ratio|compound|START_ENTITY Predictor|nsubj|Ratio END_ENTITY|parataxis|Predictor	Apo_B / Apo_A-I Ratio is Statistically A Better Predictor of Cardiovascular_Disease -LRB- CVD -RRB- than Conventional Lipid Profile : A Study from Kathmandu Valley , Nepal .
18157393	0	Apo_B	0,5	Apo_A-I	6,13	Apo B	Apo A-I	338	335	Gene	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	Apo_B / Apo_A-I ratio in central and peripheral arterial_diseases .
24701475	0	Apo_B	0,5	Apo_A-I	6,13	Apo B	Apo A-I	338	335	Gene	Gene	START_ENTITY|parataxis|Predictor Predictor|nsubj|Ratio Ratio|compound|END_ENTITY	Apo_B / Apo_A-I Ratio is Statistically A Better Predictor of Cardiovascular_Disease -LRB- CVD -RRB- than Conventional Lipid Profile : A Study from Kathmandu Valley , Nepal .
26824441	0	Apo_E	105,110	BMP-7	0,5	Apo E	BMP-7	11816(Tax:10090)	12162(Tax:10090)	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	BMP-7 Treatment Increases M2 Macrophage Differentiation and Reduces Inflammation and Plaque Formation in Apo_E - / - Mice .
25656378	0	Apo_E	41,46	apolipoprotein_E	23,39	Apo E	apolipoprotein E	348	348	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Lack of association of apolipoprotein_E -LRB- Apo_E -RRB- polymorphism with the prevalence of metabolic_syndrome : the National Heart , Lung and Blood Institute Family Heart Study .
2618138	0	Apo_E	132,137	apolipoprotein_E	114,130	Apo E	apolipoprotein E	348	348	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Methodologic studies of the isolation of VLDL using the lipoprotein precipitation reaction in the preparation of apolipoprotein_E -LRB- Apo_E -RRB- -RSB- .
22138303	0	Apo_J	0,5	clusterin	6,15	Apo J	clusterin	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Apo_J / clusterin expression and secretion : evidence for 15-deoxy - -LRB- 12,14 -RRB- - PGJ -LRB- 2 -RRB- - dependent mechanism .
7597652	0	Apob	89,93	apolipoprotein_B	71,87	Apob	apolipoprotein B	238055(Tax:10090)	238055(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein_B -LRB- Apob -RRB- gene .
20562239	0	Apoe	26,30	Npc1	35,39	Apoe	Npc1	11816(Tax:10090)	18145(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Reduced VLDL clearance in Apoe -LRB- - / - -RRB- Npc1 -LRB- - / - -RRB- mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels .
16102527	0	Apoer2	0,6	reelin	10,16	Apoer2	reelin	7804	5649	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	Apoer2 : a reelin receptor to remember .
16453339	0	Apolipoprotein	0,14	APOE	16,20	Apolipoprotein	APOE	348	348	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Apolipoprotein -LRB- APOE -RRB- gene is associated with progression of age-related_macular_degeneration -LRB- AMD -RRB- .
17906976	0	Apolipoprotein_A-I	0,18	ATP-binding_cassette_transporter_A1	99,134	Apolipoprotein A-I	ATP-binding cassette transporter A1	335	19	Gene	Gene	lipoproteins|amod|START_ENTITY internalised|nsubjpass|lipoproteins internalised|nmod|macrophages macrophages|dep|roles roles|nmod|END_ENTITY	Apolipoprotein_A-I but not high-density lipoproteins are internalised by RAW macrophages : roles of ATP-binding_cassette_transporter_A1 and scavenger_receptor_BI .
22786446	0	Apolipoprotein_A-I	0,18	CD40	28,32	Apolipoprotein A-I	CD40	335	958	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Apolipoprotein_A-I inhibits CD40 proinflammatory signaling via ATP-binding_cassette_transporter_A1-mediated modulation of lipid raft in macrophages .
16443932	0	Apolipoprotein_A-I	0,18	Cdc42	29,34	Apolipoprotein A-I	Cdc42	335	998	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Apolipoprotein_A-I activates Cdc42 signaling through the ABCA1 transporter .
16259956	0	Apolipoprotein_A-I	0,18	IL-10	27,32	Apolipoprotein A-I	IL-10	335	3586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Apolipoprotein_A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation .
9837875	0	Apolipoprotein_A-I	0,18	LL-37	80,85	Apolipoprotein A-I	LL-37	335	820	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Apolipoprotein_A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37 .
26813964	0	Apolipoprotein_A-I	16,34	PPARy	0,5	Apolipoprotein A-I	PPARy	335	5468	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	PPARy Represses Apolipoprotein_A-I Gene but Impedes TNFa-Mediated ApoA-I Downregulation in HepG2 Cells .
22425626	0	Apolipoprotein_A-I	0,18	apolipoprotein_B	20,36	Apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	C-reactive_protein|amod|START_ENTITY C-reactive_protein|amod|END_ENTITY	Apolipoprotein_A-I , apolipoprotein_B , high-sensitivity C-reactive_protein and severity of coronary_artery_disease in Tunisian population .
10488140	0	Apolipoprotein_A-I	0,18	apolipoprotein_E	43,59	Apolipoprotein A-I	apolipoprotein E	335	348	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Apolipoprotein_A-I stimulates secretion of apolipoprotein_E by foam cell macrophages .
15375180	0	Apolipoprotein_A-I	0,18	cytosolic_lipid-protein_particle	73,105	Apolipoprotein A-I	cytosolic lipid-protein particle	25081(Tax:10116)	301117(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Apolipoprotein_A-I induces translocation of protein_kinase_C -LSB- alpha -RSB- to a cytosolic_lipid-protein_particle in astrocytes .
10944531	0	Apolipoprotein_A-I	0,18	hepatic_lipase	49,63	Apolipoprotein A-I	hepatic lipase	335	3990	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Apolipoprotein_A-I regulates lipid hydrolysis by hepatic_lipase .
11290601	0	Apolipoprotein_A-I	0,18	interleukin-1beta	46,63	Apolipoprotein A-I	interleukin-1beta	281632(Tax:9913)	281251(Tax:9913)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Apolipoprotein_A-I inhibits the production of interleukin-1beta and tumor_necrosis_factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes .
7588308	0	Apolipoprotein_A-I	0,18	placental_lactogen	30,48	Apolipoprotein A-I	placental lactogen	335	1443	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Apolipoprotein_A-I stimulates placental_lactogen expression by human trophoblast cells .
9806357	0	Apolipoprotein_A-I	0,18	placental_lactogen	36,54	Apolipoprotein A-I	placental lactogen	335	1443	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Apolipoprotein_A-I stimulates human placental_lactogen release by activation of MAP kinase .
12952980	0	Apolipoprotein_A-I	0,18	protein_kinase_C_alpha	29,51	Apolipoprotein A-I	protein kinase C alpha	335	5578	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Apolipoprotein_A-I activates protein_kinase_C_alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly .
24311788	0	Apolipoprotein_A-IV	0,19	NR1D1	77,82	Apolipoprotein A-IV	NR1D1	11808(Tax:10090)	217166(Tax:10090)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Apolipoprotein_A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1 .
8739280	0	Apolipoprotein_AI_and_apolipoprotein_B	0,38	apolipoprotein_E	126,142	Apolipoprotein AI and apolipoprotein B	apolipoprotein E	335;338	348	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|END_ENTITY	Apolipoprotein_AI_and_apolipoprotein_B containing particle analysis in normolipidemic hemodialyzed patients : evidence of free apolipoprotein_E .
9278400	0	Apolipoprotein_B	0,16	ER-60_protease	55,69	Apolipoprotein B	ER-60 protease	54225(Tax:10116)	29468(Tax:10116)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Apolipoprotein_B is intracellularly associated with an ER-60_protease homologue in HepG2 cells .
15345795	0	Apolipoprotein_B	0,16	apolipoprotein_A-I	17,35	Apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	START_ENTITY|dep|relation relation|dep|END_ENTITY	Apolipoprotein_B / apolipoprotein_A-I in relation to the metabolic_syndrome and change in carotid artery intima-media_thickness during 3 years in middle-aged men .
18521458	0	Apolipoprotein_B	0,16	apolipoprotein_A-I	17,35	Apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Apolipoprotein_B / apolipoprotein_A-I ratio in relation to various definitions of metabolic_syndrome among Saudi patients with type_2_diabetes_mellitus .
1756599	0	Apolipoprotein_B	0,16	apolipoprotein_B	42,58	Apolipoprotein B	apolipoprotein B	338	338	Gene	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	Apolipoprotein_B polymorphism and altered apolipoprotein_B concentrations in Congolese blacks .
2302419	0	Apolipoprotein_C-1	0,18	phospholipase_A2	46,62	Apolipoprotein C-1	phospholipase A2	341	151056	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Apolipoprotein_C-1 inhibits the hydrolysis by phospholipase_A2 of phospholipids in liposomes and cell membranes .
2266137	0	Apolipoprotein_C-I	0,18	apolipoprotein_E	48,64	Apolipoprotein C-I	apolipoprotein E	341	348	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|interaction interaction|nmod|END_ENTITY	Apolipoprotein_C-I modulates the interaction of apolipoprotein_E with beta-migrating very low density lipoproteins -LRB- beta-VLDL -RRB- and inhibits binding of beta-VLDL to low density lipoprotein_receptor-related_protein .
19417222	0	Apolipoprotein_CI	0,17	cholesteryl_ester_transfer_protein	50,84	Apolipoprotein CI	cholesteryl ester transfer protein	341	1071	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	Apolipoprotein_CI is a physiological regulator of cholesteryl_ester_transfer_protein activity in human plasma but not in rabbit plasma .
10974550	0	Apolipoprotein_CII	0,18	apolipoprotein_CII	130,148	Apolipoprotein CII	apolipoprotein CII	100135886(Tax:8022)	344	Gene	Gene	active|nsubj|START_ENTITY active|nmod|END_ENTITY	Apolipoprotein_CII from rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- is functionally active but structurally very different from mammalian apolipoprotein_CII .
25836672	0	Apolipoprotein_CIII	0,19	lipoprotein-associated_phospholipase_A2	30,69	Apolipoprotein CIII	lipoprotein-associated phospholipase A2	345	7941	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Apolipoprotein_CIII regulates lipoprotein-associated_phospholipase_A2 expression via the MAPK and NFkB pathways .
20829510	0	Apolipoprotein_CIII	0,19	monocyte_chemoattractant_protein-1	28,62	Apolipoprotein CIII	monocyte chemoattractant protein-1	11814(Tax:10090)	20296(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Apolipoprotein_CIII induces monocyte_chemoattractant_protein-1 and interleukin_6 expression via Toll-like_receptor_2 pathway in mouse adipocytes .
16894036	0	Apolipoprotein_CIII	0,19	vascular_cell_adhesion_molecule-1	42,75	Apolipoprotein CIII	vascular cell adhesion molecule-1	345	7412	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Apolipoprotein_CIII induces expression of vascular_cell_adhesion_molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells .
22221592	0	Apolipoprotein_E	0,16	APOE	23,27	Apolipoprotein E	APOE	348	348	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Apolipoprotein_E gene -LRB- APOE -RRB- genotype in Wilson 's _ disease : impact on clinical presentation .
26574962	0	Apolipoprotein_E	31,47	APOE	49,53	Apolipoprotein E	APOE	348	348	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	-LSB- Prevalence of Variants in the Apolipoprotein_E -LRB- APOE -RRB- Gene in a General Population of Adults from an Urban Area of Medellin -LRB- Antioquia -RRB- -RSB- .
27033052	0	Apolipoprotein_E	15,31	ApoE	33,37	Apolipoprotein E	ApoE	348	348	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of Apolipoprotein_E -LRB- ApoE -RRB- polymorphism with Alzheimer 's _ Disease in Chinese population .
25140128	0	Apolipoprotein_E	64,80	Haptoglobin	0,11	Apolipoprotein E	Haptoglobin	25728(Tax:10116)	24464(Tax:10116)	Gene	Gene	trafficking|amod|START_ENTITY hippocampus|dobj|trafficking hippocampus|nsubj|increases increases|compound|END_ENTITY	Haptoglobin increases with age in rat hippocampus and modulates Apolipoprotein_E mediated cholesterol trafficking in neuroblastoma cell lines .
23675033	0	Apolipoprotein_E	100,116	LDL_Receptor	117,129	Apolipoprotein E	LDL Receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	Mice|compound|START_ENTITY Mice|compound|END_ENTITY	Medial Expression of TNF-a and TNF Receptors Precedes the Development of Atherosclerotic Lesions in Apolipoprotein_E / LDL_Receptor Double Knockout Mice .
25903128	0	Apolipoprotein_E	0,16	RhoA	70,74	Apolipoprotein E	RhoA	348	387	Gene	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Apolipoprotein_E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway .
26313465	0	Apolipoprotein_E	51,67	Scavenger_Receptor_Class_B_Type_I	0,33	Apolipoprotein E	Scavenger Receptor Class B Type I	11816(Tax:10090)	20778(Tax:10090)	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Scavenger_Receptor_Class_B_Type_I Regulates Plasma Apolipoprotein_E Levels and Dietary Lipid Deposition to the Liver .
26374899	0	Apolipoprotein_E	0,16	Triggering_Receptor_Expressed_on_Myeloid_Cells_2	33,81	Apolipoprotein E	Triggering Receptor Expressed on Myeloid Cells 2	348	54209	Gene	Gene	Ligand|nsubj|START_ENTITY Ligand|nmod|END_ENTITY	Apolipoprotein_E Is a Ligand for Triggering_Receptor_Expressed_on_Myeloid_Cells_2 -LRB- TREM2 -RRB- .
16465461	0	Apolipoprotein_E	0,16	angiotensin-converting_enzyme	18,47	Apolipoprotein E	angiotensin-converting enzyme	348	1636	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Apolipoprotein_E , angiotensin-converting_enzyme and kallikrein gene polymorphisms and the risk of Alzheimer 's _ disease and vascular_dementia .
12676346	0	Apolipoprotein_E	0,16	apoE	18,22	Apolipoprotein E	apoE	348	348	Gene	Gene	dependent|advmod|START_ENTITY dependent|dep|END_ENTITY	Apolipoprotein_E -LRB- apoE -RRB- uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells .
19733021	0	Apolipoprotein_E	0,16	apoE	18,22	Apolipoprotein E	apoE	348	348	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Apolipoprotein_E -LRB- apoE -RRB- polymorphism : a risk factor for fatal coronary_sclerosis ?
7814023	0	Apolipoprotein_E	0,16	apoE	18,22	Apolipoprotein E	apoE	348	348	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Apolipoprotein_E -LRB- apoE -RRB- polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer 's _ disease .
8813351	0	Apolipoprotein_E	0,16	apoE	18,22	Apolipoprotein E	apoE	348	348	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Apolipoprotein_E -LRB- apoE -RRB- levels in brains from Alzheimer_disease patients and controls .
8040342	0	Apolipoprotein_E	0,16	beta_amyloid_peptide	33,53	Apolipoprotein E	beta amyloid peptide	348	351	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Apolipoprotein_E associates with beta_amyloid_peptide of Alzheimer 's _ disease to form novel monofibrils .
17923100	0	Apolipoprotein_E	0,16	low-density_lipoprotein_receptor	49,81	Apolipoprotein E	low-density lipoprotein receptor	348	3949	Gene	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Apolipoprotein_E isoform-specific binding to the low-density_lipoprotein_receptor .
10456843	0	Apolipoprotein_E	0,16	low_density_lipoprotein_receptor	112,144	Apolipoprotein E	low density lipoprotein receptor	25728(Tax:10116)	300438(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY mediated|nsubjpass|stimulation mediated|nmod|members members|nmod|superfamily superfamily|compound|END_ENTITY	Apolipoprotein_E peptide stimulation of rat ovarian theca cell androgen synthesis is mediated by members of the low_density_lipoprotein_receptor superfamily .
10884290	0	Apolipoprotein_E	0,16	low_density_lipoprotein_receptor	18,50	Apolipoprotein E	low density lipoprotein receptor	348	3949	Gene	Gene	START_ENTITY|dep|interaction interaction|compound|END_ENTITY	Apolipoprotein_E ; - low_density_lipoprotein_receptor interaction .
7700578	0	Apolipoprotein_E	0,16	low_density_lipoprotein_receptor	116,148	Apolipoprotein E	low density lipoprotein receptor	348	3949	Gene	Gene	START_ENTITY|dobj|uptake uptake|nmod|pathway pathway|nmod|END_ENTITY	Apolipoprotein_E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low_density_lipoprotein_receptor .
22848862	0	Apolipoprotein_J	36,52	Clusterin	53,62	Apolipoprotein J	Clusterin	1191	1191	Gene	Gene	Study|nmod|START_ENTITY Study|dep|Expression Expression|compound|END_ENTITY	Retrospective Case-Control Study of Apolipoprotein_J / Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis .
21390319	0	Apolipoprotein_M	0,16	APOM	23,27	Apolipoprotein M	APOM	55937	55937	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Apolipoprotein_M gene -LRB- APOM -RRB- polymorphism modifies metabolic and disease traits in type_2_diabetes .
25987835	0	Apolipoprotein_M	0,16	LRH-1	55,60	Apolipoprotein M	LRH-1	55937	2494	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Apolipoprotein_M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells .
25987835	0	Apolipoprotein_M	0,16	LRH-1	55,60	Apolipoprotein M	LRH-1	55937	2494	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Apolipoprotein_M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells .
25341235	0	Apolipoprotein_b	0,16	apolipoprotein_a-I	17,35	Apolipoprotein b	apolipoprotein a-I	338	335	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Apolipoprotein_b / apolipoprotein_a-I ratio in relation to the metabolic_syndrome , its components , total cholesterol and low-density lipoprotein cholesterol in the population of georgia .
20479256	0	Apollo	12,18	SNM1B	20,25	Apollo	SNM1B	64858	64858	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Function of Apollo -LRB- SNM1B -RRB- at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson_syndrome .
25136257	0	Apom	41,45	apolipoprotein_M	23,39	Apom	apolipoprotein M	55939(Tax:10116)	55939(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Rosiglitazone enhances apolipoprotein_M -LRB- Apom -RRB- expression in rat 's liver .
17353005	0	Apoprotein_E	0,12	TNF-alpha	86,95	Apoprotein E	TNF-alpha	348	7124	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Apoprotein_E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF-alpha and IL-6 in macrophages .
12745083	0	Apoptin	24,31	Hippi	47,52	Apoptin	Hippi	1494446(Tax:12618)	55081	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The viral death protein Apoptin interacts with Hippi , the protein interactor of Huntingtin-interacting_protein_1 .
23801113	0	Apoptosis-antagonizing_transcription_factor	0,43	estrogen_receptor	121,138	Apoptosis-antagonizing transcription factor	estrogen receptor	26574	2099	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Apoptosis-antagonizing_transcription_factor -LRB- AATF -RRB- gene silencing : role in induction of apoptosis and down-regulation of estrogen_receptor in breast_cancer cells .
22934972	0	Apoptosis-associated_speck-like_protein_containing_a_CARD	0,57	ASC	59,62	Apoptosis-associated speck-like protein containing a CARD	ASC	29108	29108	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Apoptosis-associated_speck-like_protein_containing_a_CARD -LRB- ASC -RRB- expression profiles in familial_Mediterranean_fever -LRB- FMF -RRB- patients with different MEFV mutation patterns .
21664907	0	Apoptosis-inducing_factor	0,25	C/EBPa	46,52	Apoptosis-inducing factor	C/EBPa	9131	1050	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Apoptosis-inducing_factor is a target gene of C/EBPa and participates in adipocyte differentiation .
25135476	0	Apoptosis_Signal-Regulating_Kinase_1	95,131	Death-Associated_Protein_Kinase_1	18,51	Apoptosis Signal-Regulating Kinase 1	Death-Associated Protein Kinase 1	26408(Tax:10090)	69635(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Expression Expression|compound|END_ENTITY	Regulation of the Death-Associated_Protein_Kinase_1 Expression and Autophagy via ATF6 Requires Apoptosis_Signal-Regulating_Kinase_1 .
25391652	0	Apoptosis_Signal-regulating_Kinase_1	8,44	ASK1	46,50	Apoptosis Signal-regulating Kinase 1	ASK1	4217	4217	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Apoptosis_Signal-regulating_Kinase_1 -LRB- ASK1 -RRB- as an Activator of the GAPDH-Siah1 Stress-Signaling Cascade .
20200402	0	Apoptosis_signal-regulating_kinase_1	0,36	COX-2	62,67	Apoptosis signal-regulating kinase 1	COX-2	4217	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Apoptosis_signal-regulating_kinase_1 in peptidoglycan-induced COX-2 expression in macrophages .
16476732	0	Apoptosis_signal-regulating_kinase_1	0,36	E2F1	59,63	Apoptosis signal-regulating kinase 1	E2F1	4217	1869	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Apoptosis_signal-regulating_kinase_1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity .
23892595	0	Apoptosis_signal-regulating_kinase_1	0,36	brain-derived_neurotrophic_factor	52,85	Apoptosis signal-regulating kinase 1	brain-derived neurotrophic factor	4217	627	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Apoptosis_signal-regulating_kinase_1 is involved in brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - enhanced cell motility and matrix_metalloproteinase_1 expression in human chondrosarcoma cells .
14755728	0	Aprataxin	0,9	EAOH	37,41	Aprataxin	EAOH	54840	54840	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Aprataxin , the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein .
18607959	0	Aqp6	50,54	aquaporin-6	37,48	Aqp6	aquaporin-6	29170(Tax:10116)	29170(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and immunolocalization of aquaporin-6 -LRB- Aqp6 -RRB- in the rat inner ear .
10449905	0	Aqp8	107,111	aquaporin-8	75,86	Aqp8	aquaporin-8	11833(Tax:10090)	11833(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning , structural organization and chromosomal localization of the mouse aquaporin-8 water channel gene -LRB- Aqp8 -RRB- .
26923194	0	Aquaporin-1	12,23	AQP1	25,29	Aquaporin-1	AQP1	358	358	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Endothelial Aquaporin-1 -LRB- AQP1 -RRB- Expression Is Regulated by Transcription Factor Mef2c .
26923194	0	Aquaporin-1	12,23	Mef2c	79,84	Aquaporin-1	Mef2c	358	4208	Gene	Gene	Expression|compound|START_ENTITY Regulated|nsubjpass|Expression Regulated|nmod|END_ENTITY	Endothelial Aquaporin-1 -LRB- AQP1 -RRB- Expression Is Regulated by Transcription Factor Mef2c .
11929850	0	Aquaporin-2	27,38	Aquaporin-2	61,72	Aquaporin-2	Aquaporin-2	359	359	Gene	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic_diabetes_insipidus .
11929850	0	Aquaporin-2	61,72	Aquaporin-2	27,38	Aquaporin-2	Aquaporin-2	359	359	Gene	Gene	mutant|nmod|START_ENTITY mutant|compound|END_ENTITY	Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic_diabetes_insipidus .
26923934	0	Aquaporin-3	34,45	vitiligo	57,65	Aquaporin-3	vitiligo	360	246319	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Immunohistochemical expression of Aquaporin-3 protein in vitiligo ; a new potential guide for disease activity .
27057365	0	Aquaporin-4	49,60	Glutamate_Transporter-1	61,84	Aquaporin-4	Glutamate Transporter-1	361	6506	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	The Neuroprotective Effect of the Association of Aquaporin-4 / Glutamate_Transporter-1 against Alzheimer 's _ Disease .
22473056	0	Aquaporin-4	0,11	glutamate_transporter-1	137,160	Aquaporin-4	glutamate transporter-1	11829(Tax:10090)	20511(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY impairs|nsubj|deficiency impairs|dobj|plasticity plasticity|dep|involvement involvement|nmod|downregulation downregulation|nmod|expression expression|amod|END_ENTITY	Aquaporin-4 deficiency impairs synaptic plasticity and associative fear memory in the lateral amygdala : involvement of downregulation of glutamate_transporter-1 expression .
23051665	0	Aquaporin-4	0,11	glutamate_transporter-1	72,95	Aquaporin-4	glutamate transporter-1	11829(Tax:10090)	20511(Tax:10090)	Gene	Gene	attenuates|amod|START_ENTITY opioid_dependence|nsubj|attenuates opioid_dependence|advcl|suppressing suppressing|dobj|down-regulation down-regulation|amod|END_ENTITY	Aquaporin-4 deficiency attenuates opioid_dependence through suppressing glutamate_transporter-1 down-regulation and maintaining glutamate homeostasis .
17337204	0	Aquaporin-9	35,46	AQP9	48,52	Aquaporin-9	AQP9	366	366	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Stress-induced changes in neuronal Aquaporin-9 -LRB- AQP9 -RRB- in a retinal_ganglion cell-line .
25270793	0	Aquaporin-9	0,11	cystic_fibrosis_transmembrane_conductance_regulator	69,120	Aquaporin-9	cystic fibrosis transmembrane conductance regulator	65054(Tax:10116)	24255(Tax:10116)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic_fibrosis_transmembrane_conductance_regulator .
23164158	0	Aquaporin_1	0,11	AQP1	13,17	Aquaporin 1	AQP1	358	358	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Aquaporin_1 -LRB- AQP1 -RRB- expression in experimentally induced osteoarthritic_knee_menisci : an in vivo and in vitro study .
24629225	0	Aquaporin_3	31,42	AQP3	44,48	Aquaporin 3	AQP3	443047(Tax:9940)	443047(Tax:9940)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of Aquaporin_3 -LRB- AQP3 -RRB- in folliculogenesis of ewes .
10869574	0	Aquaporin_3	0,11	cystic_fibrosis_transmembrane_conductance_regulator	59,110	Aquaporin 3	cystic fibrosis transmembrane conductance regulator	494589(Tax:8355)	373725(Tax:8355)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Aquaporin_3 cloned from Xenopus_laevis is regulated by the cystic_fibrosis_transmembrane_conductance_regulator .
11231003	0	Aquaporin_3	0,11	p73	63,66	Aquaporin 3	p73	11828(Tax:10090)	22062(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Aquaporin_3 , a glycerol and water transporter , is regulated by p73 of the p53 family .
14504245	0	Arabidopsis_histone_deacetylase_1	66,99	AtHD1	101,106	Arabidopsis histone deacetylase 1	AtHD1	829969(Tax:3702)	829969(Tax:3702)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Genetic control of developmental changes induced by disruption of Arabidopsis_histone_deacetylase_1 -LRB- AtHD1 -RRB- expression .
24002911	0	Arabidopsis_vacuolar_pyrophosphatase	81,117	AVP1	119,123	Arabidopsis vacuolar pyrophosphatase	AVP1	838138(Tax:3702)	838138(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic improvement of sugarcane for drought and salinity stress tolerance using Arabidopsis_vacuolar_pyrophosphatase -LRB- AVP1 -RRB- gene .
26276392	0	Arachidonate_15-Lipoxygenase	40,68	AMP-activated_Protein_Kinase	0,28	Arachidonate 15-Lipoxygenase	AMP-activated Protein Kinase	246	5563	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	AMP-activated_Protein_Kinase Suppresses Arachidonate_15-Lipoxygenase Expression in Interleukin-4-polarized Human Macrophages .
26944113	0	Arachidonate_5-lipoxygenase	0,27	ALOX5	29,34	Arachidonate 5-lipoxygenase	ALOX5	240	240	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Arachidonate_5-lipoxygenase -LRB- ALOX5 -RRB- gene polymorphism is associated with Alzheimer 's _ disease and body mass index .
18775537	0	Arachidonate_5-lipoxygenase-activating_protein	0,46	ALOX5AP	48,55	Arachidonate 5-lipoxygenase-activating protein	ALOX5AP	241	241	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and coronary_heart_disease risk in familial_hypercholesterolemia .
24635928	0	Arachidonate_5-lipoxygenase-activating_protein	0,46	ALOX5AP	48,55	Arachidonate 5-lipoxygenase-activating protein	ALOX5AP	241	241	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene rs4073259 polymorphism not associated with ischemic_stroke in the northeastern Chinese Han population .
21813681	0	Arc	25,28	Arc	69,72	Arc	Arc	54323(Tax:10116)	54323(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	The importance of having Arc : expression of the immediate-early gene Arc is required for hippocampus-dependent fear conditioning and blocked by NMDA receptor antagonism .
21813681	0	Arc	69,72	Arc	25,28	Arc	Arc	54323(Tax:10116)	54323(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	The importance of having Arc : expression of the immediate-early gene Arc is required for hippocampus-dependent fear conditioning and blocked by NMDA receptor antagonism .
21664256	0	Arc	68,71	activity-regulated_cytoskeletal-associated_protein	16,66	Arc	activity-regulated cytoskeletal-associated protein	11838(Tax:10090)	11838(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Novelty-induced activity-regulated_cytoskeletal-associated_protein -LRB- Arc -RRB- expression in frontal cortex requires serotonin 2A receptor activation .
19576731	0	Arc	89,92	activity-regulated_cytoskeletal_associated_protein	37,87	Arc	activity-regulated cytoskeletal associated protein	54323(Tax:10116)	54323(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression and modulation of activity-regulated_cytoskeletal_associated_protein -LRB- Arc -RRB- in serotonin_transporter knockout rats .
19159662	0	Arc	72,75	activity-regulated_cytoskeleton_associated_protein	20,70	Arc	activity-regulated cytoskeleton associated protein	23237	23237	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Estrogen stimulates activity-regulated_cytoskeleton_associated_protein -LRB- Arc -RRB- expression via the MAPK - and PI-3K-dependent pathways in SH-SY5Y cells .
22404904	0	Arc	60,63	brain-derived_neurotrophic_factor	101,134	Arc	brain-derived neurotrophic factor	11838(Tax:10090)	12064(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|role role|nmod|END_ENTITY	Induction of the plasticity-associated immediate early gene Arc by stress and hallucinogens : role of brain-derived_neurotrophic_factor .
15781476	0	Arf-1	13,18	membrin	41,48	Arf-1	membrin	375	9570	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Targeting of Arf-1 to the early Golgi by membrin , an ER-Golgi SNARE .
20534529	0	Arf-bp1	11,18	Rev-erb_alpha	97,110	Arf-bp1	Rev-erb alpha	59026(Tax:10090)	217166(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb_alpha .
22573888	0	Arf1	65,69	ARAP1	0,5	Arf1	ARAP1	375	116985	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5 .
25114232	0	Arf1	14,18	EFA6	0,4	Arf1	EFA6	375	5662	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	EFA6 controls Arf1 and Arf6 activation through a negative feedback loop .
26208648	0	Arf1	48,52	Memb11	13,19	Arf1	Memb11	842268(Tax:3702)	818264(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Qb-SNARE Memb11 interacts specifically with Arf1 in the Golgi apparatus of Arabidopsis_thaliana .
26208648	0	Arf1	48,52	Memb11	13,19	Arf1	Memb11	842268(Tax:3702)	818264(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Qb-SNARE Memb11 interacts specifically with Arf1 in the Golgi apparatus of Arabidopsis_thaliana .
12771146	0	Arf1	35,39	Pyk2	20,24	Arf1	Pyk2	375	2185	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1 .
23295182	0	Arf6	22,26	ARAP2	0,5	Arf6	ARAP2	382	116984	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology .
20525696	0	Arf6	154,158	Cytohesin-2	0,11	Arf6	Cytohesin-2	11845(Tax:10090)	19158(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY migration|nmod|activation regulates|dobj|migration regulates|nsubj|ARNO ARNO|compound|END_ENTITY	Cytohesin-2 / ARNO , through its interaction with focal adhesion adaptor protein paxillin , regulates preadipocyte migration via the downstream activation of Arf6 .
23603394	0	Arf6	15,19	EFA6	0,4	Arf6	EFA6	382	5662	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis .
24261326	0	Arf6	48,52	EFA6A	0,5	Arf6	EFA6A	11845(Tax:10090)	73728(Tax:10090)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	EFA6A , a guanine_nucleotide exchange factor for Arf6 , interacts with sorting_nexin-1 and regulates neurite outgrowth .
17398097	0	Arf6	14,18	GULP	84,88	Arf6	GULP	382	51454	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP .
22085542	0	Arf6	76,80	HGF	62,65	Arf6	HGF	490679(Tax:9615)	403441(Tax:9615)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration .
20945365	0	Arf6	32,36	PIP5K	14,19	Arf6	PIP5K	382	79837	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of PIP5K activity by Arf6 and its physiological significance .
16148947	0	Arf6	34,38	Rab11-FIP3	0,10	Arf6	Rab11-FIP3	382	9727;8766;8517	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis .
22344257	0	Arf6	16,20	Rab35	0,5	Arf6	Rab35	79121(Tax:10116)	288700(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Rab35 regulates Arf6 activity through centaurin-b2 -LRB- ACAP2 -RRB- during neurite outgrowth .
16213822	0	Arf6	47,51	Rac1	95,99	Arf6	Rac1	490679(Tax:9615)	403955(Tax:9615)	Gene	Gene	activation|amod|START_ENTITY couples|dobj|activation couples|nmod|activation activation|nmod|END_ENTITY	The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1 .
23223291	0	Arf6	15,19	Rac1	82,86	Arf6	Rac1	36699(Tax:7227)	38146(Tax:7227)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|downstream downstream|nmod|END_ENTITY	Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B .
21634118	0	Arf6	1,5	RalA	7,11	Arf6	RalA	382	5898	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	-LSB- Arf6 , RalA and BIRC5 protein expression in non_small_cell_lung_cancer -RSB- .
16030257	0	Arf6	22,26	SCAMP2	0,6	Arf6	SCAMP2	79121(Tax:10116)	65168(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SCAMP2 interacts with Arf6 and phospholipase_D1 and links their function to exocytotic fusion pore formation in PC12 cells .
22659138	0	Arf6	0,4	cytohesin-2	41,52	Arf6	cytohesin-2	11845(Tax:10090)	19158(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Arf6 guanine-nucleotide exchange factor , cytohesin-2 , interacts with actinin-1 to regulate neurite extension .
25326380	0	Arf6	0,4	cytohesin-2	40,51	Arf6	cytohesin-2	11845(Tax:10090)	19158(Tax:10090)	Gene	Gene	factor|nummod|START_ENTITY binds|nsubj|factor binds|amod|END_ENTITY	Arf6 guanine_nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth .
18413248	0	Arf6	62,66	neurotrophin-3	33,47	Arf6	neurotrophin-3	382	4908	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1 .
21276423	0	Arf_nucleotide_binding_site_opener	0,34	ARNO	36,40	Arf nucleotide binding site opener	ARNO	116692(Tax:10116)	116692(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Arf_nucleotide_binding_site_opener -LSB- ARNO -RSB- promotes sequential activation of Arf6 , Cdc42 and Rac1 and insulin secretion in INS 832/13 b-cells and rat islets .
23223291	0	Arfaptin	59,67	Rac1	82,86	Arfaptin	Rac1	41353(Tax:7227)	38146(Tax:7227)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B .
26438688	0	Arg1	86,90	FoxO4	0,5	Arg1	FoxO4	11846(Tax:10090)	54601(Tax:10090)	Gene	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	FoxO4 Promotes Early Inflammatory Response upon Myocardial_Infarction via Endothelial Arg1 .
26476214	0	ArgBP2	20,26	MORC2	0,5	ArgBP2	MORC2	8470	22880	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	MORC2 downregulates ArgBP2 via histone methylation in gastric_cancer cells .
26826241	0	Arginase-1	129,139	IFN-y	76,81	Arginase-1	IFN-y	383	3458	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Hepatitis_C_Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-y Production by Altering Cellular Metabolism via Arginase-1 .
21454576	0	Arginine_and_glutamate-rich_1	0,29	mediator_subunit_1	54,72	Arginine and glutamate-rich 1	mediator subunit 1	55082;157697	5469	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arginine_and_glutamate-rich_1 -LRB- ARGLU1 -RRB- interacts with mediator_subunit_1 -LRB- MED1 -RRB- and is required for estrogen_receptor-mediated gene transcription and breast_cancer cell growth .
25409942	0	Arginine_decarboxylase	8,30	ADC	32,35	Arginine decarboxylase	ADC	816149(Tax:3702)	816149(Tax:3702)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Arginine_decarboxylase -LRB- ADC -RRB- in Arabidopsis_thaliana defence against the pathogenic bacterium Pseudomonas_viridiflava .
11713645	0	Arginine_vasopressin	0,20	CFTR	31,35	Arginine vasopressin	CFTR	24221(Tax:10116)	24255(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Arginine_vasopressin regulates CFTR and ClC-2 mRNA expression in rat kidney cortex and medulla .
25381249	0	Arginyltransferase_1	14,34	Myocardin-related_Transcription_Factor_A	71,111	Arginyltransferase 1	Myocardin-related Transcription Factor A	11101	57591	Gene	Gene	Activity|compound|START_ENTITY Inhibition|nmod|Activity Inhibition|nmod|END_ENTITY	Inhibition of Arginyltransferase_1 Induces Transcriptional Activity of Myocardin-related_Transcription_Factor_A -LRB- MRTF-A -RRB- and Promotes Directional Migration .
18345015	0	Argonaute	23,32	GW182	0,5	Argonaute	GW182	36544(Tax:7227)	43808(Tax:7227)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay .
25619693	0	Argonaute1	15,25	HOS1	0,4	Argonaute1	HOS1	841262(Tax:3702)	818568(Tax:3702)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	HOS1 regulates Argonaute1 by promoting transcription of the microRNA gene MIR168b in Arabidopsis .
20696002	0	Argonaute1	62,72	P25	25,28	Argonaute1	P25	26523	54732	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The silencing suppressor P25 of Potato virus X interacts with Argonaute1 and mediates its degradation through the proteasome pathway .
26253535	0	Argonaute_2	32,43	AUF1	0,4	Argonaute 2	AUF1	27161	3184	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	AUF1 promotes let-7b loading on Argonaute_2 .
26518874	0	Argonaute_2	21,32	MiR-346	0,7	Argonaute 2	MiR-346	27161	442911	Gene	Gene	START_ENTITY|nsubj|Up-regulates Up-regulates|compound|END_ENTITY	MiR-346 Up-regulates Argonaute_2 -LRB- AGO2 -RRB- Protein Expression to Augment the Activity of Other MiRNAs and Contributes to Cervical_Cancer Cell Malignancy .
24723684	0	Argonaute_2	12,23	PICK1	0,5	Argonaute 2	PICK1	27161	9463	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	PICK1 links Argonaute_2 to endosomes in neuronal_dendrites and regulates miRNA activity .
15329724	0	Argos	0,5	epidermal_growth_factor_receptor	15,47	Argos	epidermal growth factor receptor	39833(Tax:7227)	37455(Tax:7227)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Argos inhibits epidermal_growth_factor_receptor signalling by ligand sequestration .
25963656	0	ArhGAP29	24,32	Rap1	0,4	ArhGAP29	Rap1	9411	27342	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Rap1 spatially controls ArhGAP29 to inhibit Rho signaling during endothelial barrier regulation .
23798437	0	ArhGAP29	79,87	Rasip1	0,6	ArhGAP29	Rasip1	9411	54922	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29 .
21911940	0	Arhgap24	0,8	Rac1	21,25	Arhgap24	Rac1	231532(Tax:10090)	19353(Tax:10090)	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	Arhgap24 inactivates Rac1 in mouse podocytes , and a mutant form is associated with familial focal_segmental_glomerulosclerosis .
12034501	0	Arhgap7	80,87	DLC-1	68,73	Arhgap7	DLC-1	50768(Tax:10090)	50768(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Gene structure , tissue expression , and linkage mapping of the mouse DLC-1 gene -LRB- Arhgap7 -RRB- .
25870189	0	Arhgef1	50,57	Angiotensin_II	0,14	Arhgef1	Angiotensin II	9138	183	Gene	Gene	Activates|dobj|START_ENTITY Activates|nsubj|END_ENTITY	Angiotensin_II Activates the RhoA Exchange Factor Arhgef1 in Humans .
25753579	0	Arid3a	71,77	Lin28b	0,6	Arid3a	Lin28b	13496(Tax:10090)	380669(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a .
21346191	0	Arid5a	0,6	Sox9	23,27	Arid5a	Sox9	10865	6662	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription .
17613295	0	Aristaless-related_homeobox	26,53	ARX	55,58	Aristaless-related homeobox	ARX	170302	170302	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation screening of the Aristaless-related_homeobox -LRB- ARX -RRB- gene in Thai pediatric patients with delayed development : first report from Thailand .
21496008	0	Aristaless-related_homeobox	56,83	ARX	85,88	Aristaless-related homeobox	ARX	170302	170302	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Screening and cell-based assessment of mutations in the Aristaless-related_homeobox -LRB- ARX -RRB- gene .
15319782	1	Aristaless_X	105,117	ARX	100,103	Aristaless X	ARX	170302	170302	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	The paradox of the ARX -LRB- Aristaless_X -RRB- mutations .
15850492	0	Aristaless_related_homeobox	83,110	ARX	78,81	Aristaless related homeobox	ARX	170302	170302	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	XLMR in MRX families 29 , 32 , 33 and 38 results from the dup24 mutation in the ARX -LRB- Aristaless_related_homeobox -RRB- gene .
21109559	0	Arkadia	0,7	TGF-b	20,25	Arkadia	TGF-b	54778	7040	Gene	Gene	START_ENTITY|dep|pathway pathway|amod|END_ENTITY	Arkadia -- beyond the TGF-b pathway .
24706946	0	Arl1p	74,79	Drs2p	36,41	Arl1p	Drs2p	852462(Tax:4932)	851207(Tax:4932)	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of the flippase Drs2p in modulating GTP hydrolysis of Arl1p .
15975906	0	Arl1p	32,37	Gcs1p	9,14	Arl1p	Gcs1p	852462(Tax:4932)	851372(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments .
11909968	0	Arl4	118,122	ADP-ribosylation_factor-like_4	86,116	Arl4	ADP-ribosylation factor-like 4	11861(Tax:10090)	11861(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation_factor-like_4 -LRB- Arl4 -RRB- gene .
25063455	0	Armadillo	20,29	Kinesin-II	0,10	Armadillo	Kinesin-II	31151(Tax:7227)	39332(Tax:7227)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila .
9268368	0	Arno	110,114	ARF1	63,67	Arno	ARF1	9266	375	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|nmod|END_ENTITY	Role of protein-phospholipid interactions in the activation of ARF1 by the guanine_nucleotide exchange factor Arno .
23255605	0	Arno	88,92	Sec7	73,77	Arno	Sec7	9266	9267	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Kinetics of interaction between ADP-ribosylation_factor-1 -LRB- Arf1 -RRB- and the Sec7 domain of Arno guanine_nucleotide exchange factor , modulation by allosteric factors , and the uncompetitive inhibitor brefeldin_A .
24112024	0	Arno	63,67	Sec7	48,52	Arno	Sec7	9266	9267	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors .
12520072	0	Arnt	115,119	AhR	66,69	Arnt	AhR	405	196	Gene	Gene	translocator|appos|START_ENTITY receptor|dep|translocator Correlation|appos|receptor Correlation|appos|END_ENTITY	Correlation between gene expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- , hydrocarbon receptor nuclear translocator -LRB- Arnt -RRB- , cytochromes P4501A1 -LRB- CYP1A1 -RRB- and 1B1 -LRB- CYP1B1 -RRB- , and inducibility of CYP1A1 and CYP1B1 in human lymphocytes .
9022676	0	Arnt	98,102	AhR	41,44	Arnt	AhR	100008996(Tax:9986)	100008995(Tax:9986)	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- Arnt -RRB- in adult rabbits known to be non-responsive to cytochrome_P-450_1A1 -LRB- CYP1A1 -RRB- inducers .
9022676	0	Arnt	98,102	CYP1A1	173,179	Arnt	CYP1A1	100008996(Tax:9986)	100328613(Tax:9986)	Gene	Gene	aryl_hydrocarbon_receptor|appos|START_ENTITY Expression|nmod|aryl_hydrocarbon_receptor Expression|acl|known known|xcomp|non-responsive non-responsive|nmod|inducers inducers|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- Arnt -RRB- in adult rabbits known to be non-responsive to cytochrome_P-450_1A1 -LRB- CYP1A1 -RRB- inducers .
11043581	0	Arnt	78,82	aryl_hydrocarbon_receptor_nuclear_translocator	30,76	Arnt	aryl hydrocarbon receptor nuclear translocator	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Conditional disruption of the aryl_hydrocarbon_receptor_nuclear_translocator -LRB- Arnt -RRB- gene leads to loss of target gene induction by the aryl_hydrocarbon_receptor and hypoxia-inducible factor 1alpha .
14530333	0	Arnt	77,81	arylhydrocarbon_receptor_nuclear_translocator	30,75	Arnt	arylhydrocarbon receptor nuclear translocator	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	T cell-specific disruption of arylhydrocarbon_receptor_nuclear_translocator -LRB- Arnt -RRB- gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution .
9722945	0	Arnt2	85,90	aryl_hydrocarbon_receptor_nuclear_translocator-2	35,83	Arnt2	aryl hydrocarbon receptor nuclear translocator-2	11864(Tax:10090)	11864(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Physical localization of the mouse aryl_hydrocarbon_receptor_nuclear_translocator-2 -LRB- Arnt2 -RRB- gene within the c112K deletion .
24520124	0	Arntl2	34,40	interleukin_21	44,58	Arntl2	interleukin 21	272322(Tax:10090)	60505(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Linking the circadian rhythm gene Arntl2 to interleukin_21 expression in type 1 diabetes .
23831623	0	Aromatic_hydrocarbon_receptor	0,29	vascular_endothelial_growth_factor-A	69,105	Aromatic hydrocarbon receptor	vascular endothelial growth factor-A	196	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Aromatic_hydrocarbon_receptor inhibits lysophosphatidic_acid-induced vascular_endothelial_growth_factor-A expression in PC-3_prostate_cancer cells .
10504299	0	Arp1alpha	36,45	centractin	47,57	Arp1alpha	centractin	10121	10121	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of normal and mutant Arp1alpha -LRB- centractin -RRB- differentially affects microtubule organization during mitosis and interphase .
17476322	0	Arp2/3	29,35	Abp1	47,51	Arp2/3	Abp1	10097;10096	26	Gene	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Regulation of N-WASP and the Arp2/3 complex by Abp1 controls neuronal morphology .
11157975	0	Arp2/3	88,94	Cdc42	129,134	Arp2/3	Cdc42	10097;10096	998	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	A novel neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- binding protein , WISH , induces Arp2/3 complex activation independent of Cdc42 .
22679023	0	Arp2/3	48,54	HS1	29,32	Arp2/3	HS1	10097;10096	10971	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis .
11432863	0	Arp2/3	184,190	N-WASP	226,232	Arp2/3	N-WASP	10097	8976	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Identification of another actin-related protein -LRB- Arp -RRB- 2/3 complex binding site in neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- that complements actin polymerization induced by the Arp2/3 complex activating -LRB- VCA -RRB- domain of N-WASP .
23843614	0	Arp2/3	31,37	N-WASP	50,56	Arp2/3	N-WASP	10097;10096	8976	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The antagonistic modulation of Arp2/3 activity by N-WASP , WAVE2 and PICK1 defines dynamic changes in astrocyte morphology .
15625304	0	Arp2/3	18,24	N-WASp	36,42	Arp2/3	N-WASp	10097;10096	8976	Gene	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Activation of the Arp2/3 complex by N-WASp is required for actin polymerization and contraction in smooth muscle .
16253999	0	Arp2/3	31,37	SPIN90	15,21	Arp2/3	SPIN90	10097;10096	51517	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation .
17151356	0	Arp2/3	40,46	Sla2p	103,108	Arp2/3	Sla2p	851532(Tax:4932)	855478(Tax:4932)	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Negative regulation of yeast Eps15-like Arp2/3 complex activator , Pan1p , by the Hip1R-related protein , Sla2p , during endocytosis .
12499356	0	Arp2/3	21,27	coronin	87,94	Arp2/3	coronin	851532;853528	851148(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity regulation|nmod|END_ENTITY	Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin .
16027158	0	Arp2/3	77,83	coronin_1B	19,29	Arp2/3	coronin 1B	10097;10096	57175	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of coronin_1B by protein_kinase_C regulates interaction with Arp2/3 and cell motility .
12473693	0	Arp2/3	19,25	vinculin	37,45	Arp2/3	vinculin	10097;10096	7414	Gene	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Recruitment of the Arp2/3 complex to vinculin : coupling membrane protrusion to matrix adhesion .
25682201	0	Arp3	69,73	RasGRP3	0,7	Arp3	RasGRP3	10096	25780	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	RasGRP3 regulates the migration of glioma cells via interaction with Arp3 .
24567363	0	Arp5	0,4	myocardin	27,36	Arp5	myocardin	79913	93649	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Arp5 is a key regulator of myocardin in smooth muscle cells .
7642093	0	ArrB	141,145	Arrestin_B	129,139	ArrB	Arrestin B	38993(Tax:7227)	38993(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A 3.5-kb DNA fragment contains the cis-regulatory elements for retina-specific expression and partial dosage compensation of the Arrestin_B -LRB- ArrB -RRB- gene of Drosophila miranda .
16980301	0	Arrestin-2	0,10	p105	75,79	Arrestin-2	p105	408	4790	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Arrestin-2 and G_protein-coupled_receptor_kinase_5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages .
24257757	0	Arrestin-3	0,10	c-Jun_N-terminal_kinase_1	17,42	Arrestin-3	c-Jun N-terminal kinase 1	409	5599	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Arrestin-3 binds c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding .
18647647	0	Arrestin-3	0,10	luteinizing_hormone_receptor	57,85	Arrestin-3	luteinizing hormone receptor	409	3973	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Arrestin-3 is essential for the activation of Fyn by the luteinizing_hormone_receptor -LRB- LHR -RRB- in MA-10 cells .
7642093	0	Arrestin_B	129,139	ArrB	141,145	Arrestin B	ArrB	38993(Tax:7227)	38993(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A 3.5-kb DNA fragment contains the cis-regulatory elements for retina-specific expression and partial dosage compensation of the Arrestin_B -LRB- ArrB -RRB- gene of Drosophila miranda .
10347168	0	ArsA	24,28	ATPase	4,10	ArsA	ATPase	410	1769	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	The ATPase mechanism of ArsA , the catalytic subunit of the arsenite pump .
20689763	0	Artemin	0,7	CD24	120,124	Artemin	CD24	9048	100133941	Gene	Gene	Sensitivity|compound|START_ENTITY Sensitivity|nmod|END_ENTITY	Artemin Reduces Sensitivity to Doxorubicin and Paclitaxel in Endometrial_Carcinoma Cells through Specific Regulation of CD24 .
9883723	0	Artemin	0,7	GDNF	31,35	Artemin	GDNF	9048	2668	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Artemin , a novel member of the GDNF ligand family , supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex .
23884957	0	Artemin	0,7	glial_cell_line-derived_neurotrophic_factor	11,54	Artemin	glial cell line-derived neurotrophic factor	11876(Tax:10090)	14573(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	Artemin , a glial_cell_line-derived_neurotrophic_factor family member , induces TRPM8-dependent cold_pain .
21453483	0	Artemin	54,61	miR-223	0,7	Artemin	miR-223	9048	407008	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-223 regulates migration and invasion by targeting Artemin in human esophageal_carcinoma .
18923043	0	Arx	0,3	Dlx2	26,30	Arx	Dlx2	170302	1746	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons .
21388963	0	Arx	18,21	Islet-1	0,7	Arx	Islet-1	170302	3670	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development .
24742460	0	Arx	24,27	Lhx6	0,4	Arx	Lhx6	170302	26468	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position .
26208102	0	Aryl_Hydrocarbon_Receptor	14,39	AHR	41,44	Aryl Hydrocarbon Receptor	AHR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Deficiency in Aryl_Hydrocarbon_Receptor -LRB- AHR -RRB- Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells .
26208102	0	Aryl_Hydrocarbon_Receptor	14,39	AHR	41,44	Aryl Hydrocarbon Receptor	AHR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Deficiency in Aryl_Hydrocarbon_Receptor -LRB- AHR -RRB- Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells .
26860885	0	Aryl_Hydrocarbon_Receptor	20,45	AhR	47,50	Aryl Hydrocarbon Receptor	AhR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Crucial Role of the Aryl_Hydrocarbon_Receptor -LRB- AhR -RRB- in Indoxyl_Sulfate-Induced Vascular_Inflammation .
26992058	0	Aryl_Hydrocarbon_Receptor	62,87	MMP-1	21,26	Aryl Hydrocarbon Receptor	MMP-1	25690(Tax:10116)	300339(Tax:10116)	Gene	Gene	Activation|compound|START_ENTITY END_ENTITY|nmod|Activation	Kynurenine Modulates MMP-1 and Type-I Collagen Expression via Aryl_Hydrocarbon_Receptor Activation in Dermal Fibroblasts .
26852918	0	Aryl_Hydrocarbon_Receptor	0,25	NDRG1	36,41	Aryl Hydrocarbon Receptor	NDRG1	196	10397	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Aryl_Hydrocarbon_Receptor Activates NDRG1 Transcription under Hypoxia in Breast_Cancer Cells .
25732638	0	Aryl_Hydrocarbon_Receptor_Interacting_Protein	65,110	AIP	112,115	Aryl Hydrocarbon Receptor Interacting Protein	AIP	9049	9049	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Familial Isolated Pituitary_Adenomas -LRB- FIPA -RRB- and Mutations in the Aryl_Hydrocarbon_Receptor_Interacting_Protein -LRB- AIP -RRB- Gene .
25812120	0	Aryl_Hydrocarbon_Receptor_Nuclear_Translocator	39,85	ARNT	33,37	Aryl Hydrocarbon Receptor Nuclear Translocator	ARNT	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	Results|appos|START_ENTITY Results|amod|END_ENTITY	Hepatocyte - Specific Deletion of ARNT -LRB- Aryl_Hydrocarbon_Receptor_Nuclear_Translocator -RRB- Results in Altered Fibrotic Gene Expression in the Thioacetamide Model of Liver_Injury .
22653785	0	Aryl_hydrocarbon_receptor	0,25	CD4	46,49	Aryl hydrocarbon receptor	CD4	196	920	Gene	Gene	controls|nsubj|START_ENTITY controls|ccomp|function function|nsubj|cell cell|compound|END_ENTITY	Aryl_hydrocarbon_receptor controls regulatory CD4 + T cell function .
18366646	0	Aryl_hydrocarbon_receptor_nuclear_translocator	0,46	ARNT	48,52	Aryl hydrocarbon receptor nuclear translocator	ARNT	405	405	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits : Mutation detection , case-control studies , and gene expression analysis .
22500183	0	Arylhydrocarbon_Receptor	12,36	AhR	38,41	Arylhydrocarbon Receptor	AhR	196	196	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the Arylhydrocarbon_Receptor -LRB- AhR -RRB- in the Pathology of Asthma and COPD .
19699491	0	Arylsulfatase_A	24,39	ARSA	41,45	Arylsulfatase A	ARSA	410	410	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Identification of a new Arylsulfatase_A -LRB- ARSA -RRB- gene mutation in Tunisian patients with metachromatic_leukodystrophy -LRB- MLD -RRB- .
24243352	0	Arylsulfatase_B	102,117	ARSB	119,123	Arylsulfatase B	ARSB	411	411	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Molecular Analysis of Turkish Maroteaux-Lamy Patients and Identification of One Novel Mutation in the Arylsulfatase_B -LRB- ARSB -RRB- Gene .
20679209	0	Arylsulfatase_G	9,24	ARSG	26,30	Arylsulfatase G	ARSG	22901	22901	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A canine Arylsulfatase_G -LRB- ARSG -RRB- mutation leading to a sulfatase_deficiency is associated with neuronal_ceroid_lipofuscinosis .
25792604	0	Asc1	0,4	RACK1	23,28	Asc1	RACK1	56301	10399	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Asc1 , homolog of human RACK1 , prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats .
18585058	0	Ascl1	0,5	Mash1	7,12	Ascl1	Mash1	429	429	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Ascl1 -LRB- Mash1 -RRB- lineage cells contribute to discrete cell populations in CNS architecture .
17145773	0	Asef2	0,5	Cdc42	21,26	Asef2	Asef1	221178	50649	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element .
25750125	0	Asef2	45,50	GEF	40,43	Asef2	GEF	221178	5923	Gene	Gene	START_ENTITY|nsubj|Factor Factor|appos|END_ENTITY	The Guanine Nucleotide Exchange Factor -LRB- GEF -RRB- Asef2 Promotes Dendritic Spine Formation via Rac Activation and Spinophilin-Dependent Targeting .
17599059	0	Asef2	39,44	Rac1	96,100	Asef2	Rac1	221178	5879	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of Asef2 , a guanine-nucleotide exchange factor specific for Rac1 and Cdc42 .
16407267	0	Asf1	22,26	PHO5	79,83	Asf1	PHO5	853327(Tax:4932)	852390(Tax:4932)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	The histone chaperone Asf1 increases the rate of histone eviction at the yeast PHO5 and PHO8 promoters .
11331602	0	Asf1	0,4	Rad53	11,16	Asf1	Rad53	853327(Tax:4932)	855950(Tax:4932)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Asf1 links Rad53 to control of chromatin assembly .
20048053	0	Asf1	0,4	Set2	45,49	Asf1	Set2	853327(Tax:4932)	853271(Tax:4932)	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|END_ENTITY	Asf1 can promote trimethylation of H3 K36 by Set2 .
22160571	0	Asf1p	65,70	Vip1p	26,31	Asf1p	Vip1p	853327(Tax:4932)	851126(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Inositol_phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces_cerevisiae .
22231628	0	Ash2L	38,43	RbBP5	70,75	Ash2L	RbBP5	9070	5929	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30 .
20463296	0	Ash2l	0,5	Tbx1	21,25	Ash2l	Tbx1	9070	6899	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ash2l interacts with Tbx1 and is required during early embryogenesis .
25485912	0	Ashwell-Morell_receptor	4,27	thrombopoietin	46,60	Ashwell-Morell receptor	thrombopoietin	11318	7066	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	The Ashwell-Morell_receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling .
24268318	0	Asparagine_synthetase	0,21	ASNS	23,27	Asparagine synthetase	ASNS	440	440	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Asparagine_synthetase -LRB- ASNS -RRB- gene polymorphism is associated with the outcome of childhood acute_lymphoblastic_leukemia by affecting early response to treatment .
26615011	0	Aspartate_Transaminase	11,33	AST	35,38	Aspartate Transaminase	AST	26503	26503	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	High serum Aspartate_Transaminase -LRB- AST -RRB- levels on day 3 post liver transplantation correlates with graft and patient survival and would be a valid surrogate for outcome in liver transplantation clinical trials .
8866310	0	Aspartate_aminotransferase	0,26	AST	28,31	Aspartate aminotransferase	AST	26503	26503	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Aspartate_aminotransferase -LRB- AST -RRB- levels in human periodontium-derived cells .
26683595	0	Aspartate_b-hydroxylase	0,23	glycogen_synthase_kinase_3b	62,89	Aspartate b-hydroxylase	glycogen synthase kinase 3b	444	2932	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Aspartate_b-hydroxylase modulates cellular senescence through glycogen_synthase_kinase_3b in hepatocellular_carcinoma .
26399972	0	Asporin	7,14	PLAP-1	0,6	Asporin	PLAP-1	54829	54829	Gene	Gene	Regulates|nsubj|START_ENTITY END_ENTITY|appos|Regulates	PLAP-1 / Asporin Regulates TLR2 - and TLR4-induced Inflammatory Responses .
26748699	0	Astrin	85,91	Mid2	65,69	Astrin	Mid2	10615	11043	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division .
25824750	0	Astrocyte_Elevated_Gene-1	18,43	AEG-1	45,50	Astrocyte Elevated Gene-1	AEG-1	92140	92140	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Astrocyte_Elevated_Gene-1 -LRB- AEG-1 -RRB- in Cervical_Cancer and its Correlation with Angiogenesis .
24705862	0	Astrocyte_elevated_gene-1	0,25	MMP9	36,40	Astrocyte elevated gene-1	MMP9	92140	4318	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Astrocyte_elevated_gene-1 activates MMP9 to increase invasiveness of colorectal_cancer .
19740331	0	Astrocyte_elevated_gene-1	0,25	TLR4	119,123	Astrocyte elevated gene-1	TLR4	92140	7099	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- is induced by lipopolysaccharide as toll-like_receptor_4 -LRB- TLR4 -RRB- ligand and regulates TLR4 signalling .
19740331	0	Astrocyte_elevated_gene-1	0,25	TLR4	92,96	Astrocyte elevated gene-1	TLR4	92140	7099	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|TLR4 TLR4|appos|END_ENTITY	Astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- is induced by lipopolysaccharide as toll-like_receptor_4 -LRB- TLR4 -RRB- ligand and regulates TLR4 signalling .
22431469	0	Astrocyte_elevated_gene-1	0,25	b-catenin	41,50	Astrocyte elevated gene-1	b-catenin	92140	1499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Astrocyte_elevated_gene-1 interacts with b-catenin and increases migration and invasion of colorectal_carcinoma .
20388776	0	Astrocyte_elevated_gene-1	0,25	matrix_metalloproteinase-9	38,64	Astrocyte elevated gene-1	matrix metalloproteinase-9	92140	4318	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	Astrocyte_elevated_gene-1 upregulates matrix_metalloproteinase-9 and induces human glioma_invasion .
19166903	0	At4g24220	15,24	VEP1	4,8	At4g24220	VEP1	828523(Tax:3702)	828523(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The VEP1 gene -LRB- At4g24220 -RRB- encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4 ,5 - steroid_5beta-reductase activity in Arabidopsis_thaliana L .
21696844	0	AtABCG26	22,30	ABC_transporter	35,50	AtABCG26	ABC transporter	820512(Tax:3702)	818031(Tax:3702)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Arabidopsis mutant of AtABCG26 , an ABC_transporter gene , is defective in pollen maturation .
10758491	0	AtBI-1	0,6	Bax	29,32	AtBI-1	Bax	834758(Tax:3702)	581	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	AtBI-1 , a plant homologue of Bax inhibitor-1 , suppresses Bax-induced cell death in yeast and is rapidly upregulated during wounding and pathogen challenge .
17287892	0	AtCAD5	101,107	glycine-rich_protein_AtGRP9	48,75	AtCAD5	glycine-rich protein AtGRP9	829572(Tax:3702)	815093(Tax:3702)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Root and vascular tissue-specific expression of glycine-rich_protein_AtGRP9 and its interaction with AtCAD5 , a cinnamyl_alcohol_dehydrogenase , in Arabidopsis_thaliana .
25103420	0	AtCBF3	66,72	AtCOR15A	98,106	AtCBF3	AtCOR15A	828652(Tax:3702)	818854(Tax:3702)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Heterologous expression of Arabidopsis C-repeat binding factor 3 -LRB- AtCBF3 -RRB- and cold-regulated 15A -LRB- AtCOR15A -RRB- enhanced chilling tolerance in transgenic eggplant -LRB- Solanum melongena L. -RRB- .
15592873	0	AtCDC48	60,67	SERK1	16,21	AtCDC48	SERK1	820142(Tax:3702)	843513(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The Arabidopsis SERK1 protein interacts with the AAA-ATPase AtCDC48 , the 14-3-3 protein GF14lambda and the PP2C phosphatase KAPP .
25073793	0	AtCOL4	42,48	CONSTANS-like_4	4,19	AtCOL4	CONSTANS-like 4	832563(Tax:3702)	832563(Tax:3702)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	The CONSTANS-like_4 transcription factor , AtCOL4 , positively regulates abiotic stress tolerance through an abscisic_acid-dependent manner in Arabidopsis .
25103420	0	AtCOR15A	98,106	AtCBF3	66,72	AtCOR15A	AtCBF3	818854(Tax:3702)	828652(Tax:3702)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Heterologous expression of Arabidopsis C-repeat binding factor 3 -LRB- AtCBF3 -RRB- and cold-regulated 15A -LRB- AtCOR15A -RRB- enhanced chilling tolerance in transgenic eggplant -LRB- Solanum melongena L. -RRB- .
16299177	0	AtCPK32	45,52	ABF4	68,72	AtCPK32	ABF4	824920(Tax:3702)	821463(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arabidopsis calcium-dependent protein kinase AtCPK32 interacts with ABF4 , a transcriptional regulator of abscisic_acid-responsive gene expression , and modulates its activity .
21596687	0	AtCYP71	16,23	CAF-1	39,44	AtCYP71	CAF-1	823585(Tax:3702)	8208	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The cyclophilin AtCYP71 interacts with CAF-1 and LHP1 and functions in multiple chromatin remodeling processes .
9807817	0	AtFIP37	48,55	immunophilin	15,27	AtFIP37	immunophilin	824584(Tax:3702)	836556(Tax:3702)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	An Arabidopsis immunophilin , AtFKBP12 , binds to AtFIP37 -LRB- FKBP interacting protein -RRB- in an interaction that is disrupted by FK506 .
18823312	0	AtFP6	108,113	ACBP2	46,51	AtFP6	ACBP2	830015(Tax:3702)	828891(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arabidopsis_thaliana acyl-CoA-binding protein ACBP2 interacts with heavy-metal-binding farnesylated protein AtFP6 .
19874540	0	AtGA3ox1	110,118	DAG1	16,20	AtGA3ox1	DAG1	838125(Tax:3702)	825358(Tax:3702)	Gene	Gene	regulating|dobj|START_ENTITY mediates|advcl|regulating mediates|nsubj|END_ENTITY	The Dof protein DAG1 mediates PIL5 activity on seed germination by negatively regulating GA biosynthetic gene AtGA3ox1 .
15516508	0	AtGA3ox2	0,8	LEAFY_COTYLEDON2	110,126	AtGA3ox2	LEAFY COTYLEDON2	844374(Tax:3702)	839724(Tax:3702)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	AtGA3ox2 , a key gene responsible for bioactive gibberellin biosynthesis , is regulated during embryogenesis by LEAFY_COTYLEDON2 and FUSCA3 in Arabidopsis .
14504245	0	AtHD1	101,106	Arabidopsis_histone_deacetylase_1	66,99	AtHD1	Arabidopsis histone deacetylase 1	829969(Tax:3702)	829969(Tax:3702)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Genetic control of developmental changes induced by disruption of Arabidopsis_histone_deacetylase_1 -LRB- AtHD1 -RRB- expression .
17728292	0	AtMEK1	0,6	catalase	55,63	AtMEK1	catalase	828713(Tax:3702)	829661(Tax:3702)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	AtMEK1 mediates stress-induced gene expression of CAT1 catalase by triggering H2O2 production in Arabidopsis .
15474000	0	AtMKK6	29,35	AtMPK13	61,68	AtMKK6	AtMPK13	835759(Tax:3702)	837303(Tax:3702)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The Arabidopsis_thaliana MEK AtMKK6 activates the MAP kinase AtMPK13 .
15474000	0	AtMPK13	61,68	AtMKK6	29,35	AtMPK13	AtMKK6	837303(Tax:3702)	835759(Tax:3702)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The Arabidopsis_thaliana MEK AtMKK6 activates the MAP kinase AtMPK13 .
16945961	0	AtMUS81	12,19	AtRecQ4A	80,88	AtMUS81	AtRecQ4A	829211(Tax:3702)	837636(Tax:3702)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of AtMUS81 in DNA repair and its genetic interaction with the helicase AtRecQ4A .
11967090	0	AtMYB21	0,7	COP1	81,85	AtMYB21	COP1	822401(Tax:3702)	64326	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	AtMYB21 , a gene encoding a flower-specific transcription factor , is regulated by COP1 .
21117868	0	AtMYB44	21,28	ETHYLENE_INSENSITIVE2	65,86	AtMYB44	ETHYLENE INSENSITIVE2	836865(Tax:3702)	831889(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Transcription factor AtMYB44 regulates induced expression of the ETHYLENE_INSENSITIVE2 gene in Arabidopsis responding to a harpin protein .
20496121	0	AtNEK6	0,6	ARIA	22,26	AtNEK6	ARIA	823542(Tax:3702)	641700	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	AtNEK6 interacts with ARIA and is involved in ABA response during seed germination .
18069941	0	AtNFXL1	0,7	NF-X1	68,73	AtNFXL1	NF-X1	837555(Tax:3702)	4799	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	AtNFXL1 , an Arabidopsis homologue of the human transcription factor NF-X1 , functions as a negative regulator of the trichothecene phytotoxin-induced defense response .
26878367	0	AtNUDX19	173,181	Nudix_hydrolase_19	153,171	AtNUDX19	Nudix hydrolase 19	832129(Tax:3702)	832129(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Activation of NADPH-recycling systems in leaves and roots of Arabidopsis_thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix_hydrolase_19 -LRB- AtNUDX19 -RRB- gene .
11148275	0	AtOXA1	30,36	Oxa1p	72,77	AtOXA1	Oxa1p	836325(Tax:3702)	856898(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Mitochondrial localization of AtOXA1 , an arabidopsis homologue of yeast Oxa1p involved in the insertion and assembly of protein complexes in mitochondrial inner membrane .
16361522	0	AtPP2CA	126,133	abh1	118,122	AtPP2CA	abh1	820314(Tax:3702)	815840(Tax:3702)	Gene	Gene	mRNA|amod|START_ENTITY END_ENTITY|nmod|mRNA	The protein phosphatase AtPP2CA negatively regulates abscisic_acid signal transduction in Arabidopsis , and effects of abh1 on AtPP2CA mRNA .
11725949	0	AtPRB1	39,45	PR1-like	24,32	AtPRB1	PR1-like	815945(Tax:3702)	816518(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The promoter of a basic PR1-like gene , AtPRB1 , from Arabidopsis establishes an organ-specific expression pattern and responsiveness to ethylene and methyl_jasmonate .
12837948	0	AtPirin1	37,45	GPA1	89,93	AtPirin1	GPA1	825091(Tax:3702)	817170(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Arabidopsis cupin domain protein AtPirin1 interacts with the G_protein_alpha-subunit GPA1 and regulates seed germination and early seedling development .
16786311	0	AtRAD4	74,80	XPC	61,64	AtRAD4	XPC	831525(Tax:3702)	7508	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	CENTRIN2 interacts with the Arabidopsis homolog of the human XPC protein -LRB- AtRAD4 -RRB- and contributes to efficient synthesis-dependent repair of bulky DNA lesions .
15720729	0	AtRaptor1B	42,52	AML1	31,35	AtRaptor1B	AML1	820032(Tax:3702)	836317(Tax:3702)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B , the plant homologue of a major regulator of eukaryotic cell growth .
16945961	0	AtRecQ4A	80,88	AtMUS81	12,19	AtRecQ4A	AtMUS81	837636(Tax:3702)	829211(Tax:3702)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of AtMUS81 in DNA repair and its genetic interaction with the helicase AtRecQ4A .
10898935	0	AtUBP3	115,121	AtUBP5	67,73	AtUBP3	AtUBP5	830150(Tax:3702)	818691(Tax:3702)	Gene	Gene	specificity|nmod|START_ENTITY END_ENTITY|nmod|specificity	Ubiquitin-specific proteases from Arabidopsis_thaliana : cloning of AtUBP5 and analysis of substrate specificity of AtUBP3 , AtUBP4 , and AtUBP5 using Escherichia_coli in vivo and in vitro assays .
10898935	0	AtUBP5	67,73	AtUBP3	115,121	AtUBP5	AtUBP3	818691(Tax:3702)	830150(Tax:3702)	Gene	Gene	START_ENTITY|nmod|specificity specificity|nmod|END_ENTITY	Ubiquitin-specific proteases from Arabidopsis_thaliana : cloning of AtUBP5 and analysis of substrate specificity of AtUBP3 , AtUBP4 , and AtUBP5 using Escherichia_coli in vivo and in vitro assays .
26452715	0	AtYak1	26,32	Yak1	12,16	AtYak1	Yak1	833590(Tax:3702)	833590(Tax:3702)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Arabidopsis Yak1 protein -LRB- AtYak1 -RRB- is a dual specificity protein kinase .
14744748	0	Ataxia-telangiectasia-mutated	0,29	ATM	31,34	Ataxia-telangiectasia-mutated	ATM	472	472	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ataxia-telangiectasia-mutated -LRB- ATM -RRB- gene in head_and_neck_squamous_cell_carcinoma : promoter hypermethylation with clinical correlation in 100 cases .
18171989	0	Ataxia-telangiectasia_mutated	0,29	p53	50,53	Ataxia-telangiectasia mutated	p53	11920(Tax:10090)	22060(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	Ataxia-telangiectasia_mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues .
10973490	0	Ataxia_telangiectasia-mutated	0,29	Chk2	45,49	Ataxia telangiectasia-mutated	Chk2	472	11200	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Ataxia_telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro .
20177072	0	Ataxia_telangiectasia_mutated	0,29	ATM	31,34	Ataxia telangiectasia mutated	ATM	472	472	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Ataxia_telangiectasia_mutated -LRB- ATM -RRB- inhibition transforms human mammary gland epithelial cells .
16452194	0	Ataxia_telangiectasia_mutated	0,29	BRCA1	63,68	Ataxia telangiectasia mutated	BRCA1	472	672	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Ataxia_telangiectasia_mutated and checkpoint_kinase_2 regulate BRCA1 to promote the fidelity of DNA end-joining .
16714295	0	Ataxin-10	0,9	O-linked_beta-N-acetylglucosamine_transferase	25,70	Ataxin-10	O-linked beta-N-acetylglucosamine transferase	170821(Tax:10116)	26295(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ataxin-10 interacts with O-linked_beta-N-acetylglucosamine_transferase in the brain .
16182253	0	Ataxin-10	0,9	OGT	46,49	Ataxin-10	OGT	54138(Tax:10090)	108155(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells .
17392519	0	Ataxin-2	0,8	DDX6	52,56	Ataxin-2	DDX6	6311	1656	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules .
16822850	0	Ataxin-3	0,8	VCP/p97	15,22	Ataxin-3	VCP/p97	4287	7415	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates .
16498633	0	Ataxin_10	0,9	G-protein_beta2_subunit	54,77	Ataxin 10	G-protein beta2 subunit	25814	2783	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ataxin_10 induces neuritogenesis via interaction with G-protein_beta2_subunit .
8995484	0	Atbf1	51,56	ATBF1	18,23	Atbf1	ATBF1	11906(Tax:10090)	11906(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the ATBF1 transcription factor gene -LRB- Atbf1 -RRB- to mouse chromosome band 8E1 by in situ hybridization .
18272476	0	Atbf1	0,5	Pit1	26,30	Atbf1	Pit1	463	5449	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	Atbf1 is required for the Pit1 gene early activation .
22390138	0	Atf3	112,116	Egr1	92,96	Atf3	Egr1	467	1958	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes : Egr1 is a principal Atf3 target .
25035425	0	Atf6a	121,126	Lipase_maturation_factor_1	0,26	Atf6a	Lipase maturation factor 1	226641(Tax:10090)	76483(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Lipase_maturation_factor_1 -LRB- lmf1 -RRB- is induced by endoplasmic reticulum stress through activating_transcription_factor_6a -LRB- Atf6a -RRB- signaling .
15743910	0	Atg1	36,40	Atg17	0,5	Atg1	Atg17	852695(Tax:4932)	851142(Tax:4932)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy .
19287211	0	Atg101	38,44	Atg13	15,20	Atg101	Atg13	60673	9776	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	A novel , human Atg13 binding protein , Atg101 , interacts with ULK1 and is essential for macroautophagy .
19597335	0	Atg101	0,6	Atg13	61,66	Atg101	Atg13	60673	9776	Gene	Gene	START_ENTITY|appos|protein protein|acl|interacting interacting|nmod|END_ENTITY	Atg101 , a novel mammalian autophagy protein interacting with Atg13 .
25585051	0	Atg12	8,13	pro-opiomelanocortin	32,52	Atg12	pro-opiomelanocortin	67526(Tax:10090)	18976(Tax:10090)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Loss of Atg12 , but not Atg5 , in pro-opiomelanocortin neurons exacerbates diet-induced obesity .
22885670	0	Atg13	66,71	ATG101	15,21	Atg13	ATG101	176150(Tax:6239)	60673	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|EPG-9 EPG-9|compound|END_ENTITY	The C. _ elegans ATG101 homolog EPG-9 directly interacts with EPG-1 / Atg13 and is essential for autophagy .
19287211	0	Atg13	15,20	Atg101	38,44	Atg13	Atg101	9776	60673	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A novel , human Atg13 binding protein , Atg101 , interacts with ULK1 and is essential for macroautophagy .
19597335	0	Atg13	61,66	Atg101	0,6	Atg13	Atg101	9776	60673	Gene	Gene	interacting|nmod|START_ENTITY protein|acl|interacting END_ENTITY|appos|protein	Atg101 , a novel mammalian autophagy protein interacting with Atg13 .
22885670	0	Atg13	66,71	EPG-9	30,35	Atg13	EPG-9	176150(Tax:6239)	177040(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The C. _ elegans ATG101 homolog EPG-9 directly interacts with EPG-1 / Atg13 and is essential for autophagy .
22024743	0	Atg13	0,5	Ulk1	38,42	Atg13	Ulk1	9776	8408	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction .
22797916	0	Atg14L	39,45	SNARE-associated_protein_Snapin	58,89	Atg14L	SNARE-associated protein Snapin	22863	23557	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated_protein_Snapin to coordinate endocytic trafficking .
18448665	0	Atg16L	50,56	Rab33B	28,34	Atg16L	Rab33B	55054	83452	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation .
22520467	0	Atg16L1	35,42	interferon_gamma	94,110	Atg16L1	interferon gamma	55054	3458	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Nondegradative role of Atg5-Atg12 / Atg16L1 autophagy protein complex in antiviral activity of interferon_gamma .
15743910	0	Atg17	0,5	Atg1	36,40	Atg17	Atg1	851142(Tax:4932)	852695(Tax:4932)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy .
19371383	0	Atg17	0,5	Atg9	15,19	Atg17	Atg9	851142(Tax:4932)	851406(Tax:4932)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Atg17 recruits Atg9 to organize the pre-autophagosomal structure .
19200887	0	Atg18	40,45	WIPI-1	33,39	Atg18	WIPI-1	55062	55062	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Assessing mammalian autophagy by WIPI-1 / Atg18 puncta formation .
24186333	0	Atg3	70,74	E1_and_E3	11,20	Atg3	E1 and E3	64422	6080;26765	Gene	Gene	Binding|nsubj|START_ENTITY Binding|nmod|END_ENTITY	Binding to E1_and_E3 is mutually exclusive for the human autophagy E2 Atg3 .
22644571	0	Atg3	12,16	caspase-8	28,37	Atg3	caspase-8	64422	841	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death .
26506896	0	Atg32	63,68	BCL2L13	0,7	Atg32	BCL2L13	854660(Tax:4932)	23786	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32 .
25281559	0	Atg34	45,50	Hrr25	0,5	Atg34	Hrr25	854071(Tax:4932)	855897(Tax:4932)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of a-mannosidase under nitrogen starvation conditions .
16874114	0	Atg4B	103,108	Atg4B	31,36	Atg4B	Atg4B	316640(Tax:10116)	316640(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues .
16874114	0	Atg4B	31,36	Atg4B	103,108	Atg4B	Atg4B	316640(Tax:10116)	316640(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues .
16874114	0	Atg4B	103,108	LC3	67,70	Atg4B	LC3	316640(Tax:10116)	25291(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues .
16874114	0	Atg4B	31,36	LC3	67,70	Atg4B	LC3	316640(Tax:10116)	25291(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues .
18768752	0	Atg4B	3,8	LC3	42,45	Atg4B	LC3	23192	84557	Gene	Gene	mutant|amod|START_ENTITY hampers|nsubj|mutant hampers|dobj|lipidation lipidation|nmod|paralogues paralogues|nummod|END_ENTITY	An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure .
25652854	0	Atg4a	69,74	miR-144	1,8	Atg4a	miR-144	666468(Tax:10090)	387162(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	-LSB- miR-144 regulates BCG - and rapamycin-induced autophagy by targeting Atg4a in RAW264 .7 cells -RSB- .
26975471	0	Atg5	24,28	Rab33B	68,74	Atg5	Rab33B	11793(Tax:10090)	19338(Tax:10090)	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Deciphering the role of Atg5 in nucleotide dependent interaction of Rab33B with the dimeric complex , Atg5-Atg16L1 .
24582693	0	Atg5	14,18	adiponectin	42,53	Atg5	adiponectin	9474	9370	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells .
22499945	0	Atg7	0,4	p53	15,18	Atg7	p53	74244(Tax:10090)	22060(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress .
26687600	0	Atg8	69,73	LGG-1	84,89	Atg8	LGG-1	852200(Tax:4932)	174050(Tax:6239)	Gene	Gene	Homologs|compound|START_ENTITY Homologs|amod|END_ENTITY	Structural Basis of the Differential Function of the Two C. __ elegans Atg8 Homologs , LGG-1 and LGG-2 , in Autophagy .
19371383	0	Atg9	15,19	Atg17	0,5	Atg9	Atg17	851406(Tax:4932)	851142(Tax:4932)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Atg17 recruits Atg9 to organize the pre-autophagosomal structure .
15965469	0	Atm	38,41	Nbs1	8,12	Atm	Nbs1	11920(Tax:10090)	27354(Tax:10090)	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase END_ENTITY|nmod|activation	Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models .
11238919	0	Atm	36,39	PARP-1	29,35	Atm	PARP-1	11920(Tax:10090)	11545(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development .
22065599	0	Atm	20,23	Tcl1	0,4	Atm	Tcl1	472	8115	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tcl1 interacts with Atm and enhances NF-kB activation in hematologic_malignancies .
10082576	0	Atm	0,3	p53	23,26	Atm	p53	11920(Tax:10090)	22060(Tax:10090)	Gene	Gene	dispensable|nsubj|START_ENTITY dispensable|nmod|apoptosis apoptosis|compound|END_ENTITY	Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction .
15642165	0	Atm	0,3	p53	74,77	Atm	p53	11920(Tax:10090)	22060(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|development development|nmod|mice mice|amod|mammary_carcinomas mammary_carcinomas|nmod|heterozygous heterozygous|compound|END_ENTITY	Atm heterozygous_deficiency enhances development of mammary_carcinomas in p53 heterozygous knockout mice .
18583527	0	Atm	43,46	p53	21,24	Atm	p53	11920(Tax:10090)	22060(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY suppression|nmod|absence suppression|nmod|END_ENTITY	Tumor suppression by p53 in the absence of Atm .
9632822	0	Atm	68,71	p53	15,18	Atm	p53	11920(Tax:10090)	22060(Tax:10090)	Gene	Gene	defects|nmod|START_ENTITY Involvement|nmod|defects Involvement|nmod|END_ENTITY	Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm - / - mice .
19864427	0	Atoh1	26,31	Beta-catenin	0,12	Atoh1	Beta-catenin	11921(Tax:10090)	12387(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3 ' enhancer .
22070085	0	Atoh1	38,43	CDS	49,52	Atoh1	CDS	500156(Tax:10116)	1040	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The cloning and sequencing of SD rat Atoh1 gene CDS region -RSB- .
20516124	0	Atoh1	0,5	Gli1	62,66	Atoh1	Gli1	11921(Tax:10090)	14632(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells .
18652815	0	Atoh1	21,26	Prox1	0,5	Atoh1	Prox1	11921(Tax:10090)	19130(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Prox1 interacts with Atoh1 and Gfi1 , and regulates cellular differentiation in the inner_ear_sensory_epithelia .
21801718	0	Atoh1	27,32	Sox2	0,4	Atoh1	Sox2	30303(Tax:7955)	378723(Tax:7955)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear .
20808762	0	Atoh7	23,28	Math5	30,35	Atoh7	Math5	53404(Tax:10090)	53404(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	A critical analysis of Atoh7 -LRB- Math5 -RRB- mRNA splicing in the developing mouse retina .
23836893	0	Atonal_homolog_8	25,41	Gata4	52,57	Atonal homolog 8	Gata4	71093(Tax:10090)	14463(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The transcription factor Atonal_homolog_8 regulates Gata4 and Friend of Gata-2 during vertebrate development .
12538877	0	Atox1	19,24	ATPase	88,94	Atox1	ATPase	475	1769	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase .
10555956	0	Atp1a4	29,35	alpha4	16,22	Atp1a4	alpha4	27222(Tax:10090)	3476	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Na,K-ATPase alpha4 gene -LRB- Atp1a4 -RRB- encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene -LRB- Atp1a2 -RRB- on mouse chromosome 1 .
20599950	0	Atp2c2	57,63	MIST1	0,5	Atp2c2	MIST1	69047(Tax:10090)	17341(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MIST1 regulates the pancreatic acinar cell expression of Atp2c2 , the gene encoding secretory pathway calcium ATPase 2 .
23776592	0	Atp7a	97,102	ATPase	89,95	Atp7a	ATPase	11977(Tax:10090)	13417(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Investigation of iron metabolism in mice expressing a mutant Menke 's copper transporting ATPase -LRB- Atp7a -RRB- protein with diminished activity -LRB- Brindled ; Mo -LRB- Br -RRB- -LRB- / y -RRB- -RRB- .
17344477	0	Atp9	29,33	Oxa1	0,4	Atp9	Oxa1	854584(Tax:4932)	856898(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Oxa1 directly interacts with Atp9 and mediates its assembly into the mitochondrial F1Fo-ATP synthase complex .
10859164	0	Atr	49,52	Chk1	0,4	Atr	Chk1	545	1111	Gene	Gene	regulated|nmod|START_ENTITY kinase|acl:relcl|regulated kinase|nsubj|END_ENTITY	Chk1 is an essential kinase that is regulated by Atr and required for the G -LRB- 2 -RRB- / M DNA damage checkpoint .
11069891	0	Atr	16,19	Chk1	42,46	Atr	Chk1	398197(Tax:8355)	398191(Tax:8355)	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts .
2956947	0	Atrial_natriuretic_factor	0,25	ANF	27,30	Atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Atrial_natriuretic_factor -LRB- ANF -RRB- levels are elevated in rats bearing rejecting heart-lung allografts .
2952856	0	Atrial_natriuretic_factor	0,25	alpha-MSH	58,67	Atrial natriuretic factor	alpha-MSH	4878	5443	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Atrial_natriuretic_factor -LRB- ANF -RRB- stimulates the release of alpha-MSH from frog neurointermediate lobes in vitro .
2524525	0	Atrial_natriuretic_factor	0,25	angiotensin_II	41,55	Atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	release|nsubj|START_ENTITY release|nmod|infusion infusion|amod|END_ENTITY	Atrial_natriuretic_factor release during angiotensin_II infusion in right and left atrial appendectomized rats .
2952590	0	Atrial_natriuretic_factor	0,25	angiotensin_II	43,57	Atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|responses responses|amod|END_ENTITY	Atrial_natriuretic_factor inhibits central angiotensin_II pressor responses .
2968308	0	Atrial_natriuretic_factor	0,25	angiotensin_II	37,51	Atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Atrial_natriuretic_factor release by angiotensin_II in the conscious rat .
2977176	0	Atrial_natriuretic_factor	0,25	angiotensin_II	98,112	Atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|heart heart|nmod|action action|nmod|END_ENTITY	Atrial_natriuretic_factor protects the isolated working ischaemic rat heart against the action of angiotensin_II .
6092045	0	Atrial_natriuretic_factor	0,25	angiotensin_II	79,93	Atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|stimulation stimulation|nmod|secretion secretion|nmod|END_ENTITY	Atrial_natriuretic_factor inhibits the stimulation of aldosterone secretion by angiotensin_II , ACTH and potassium in vitro and angiotensin_II-induced steroidogenesis in vivo .
7681659	0	Atrial_natriuretic_factor	0,25	calmodulin-binding_protein	65,91	Atrial natriuretic factor	calmodulin-binding protein	4878	654502	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Atrial_natriuretic_factor stimulates phosphorylation of a 52-kDa calmodulin-binding_protein in vascular smooth muscle cells .
2476609	0	Atrial_natriuretic_factor	0,25	renin	72,77	Atrial natriuretic factor	renin	4878	5972	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activity activity|compound|END_ENTITY	Atrial_natriuretic_factor attenuates prostaglandin_E2-stimulated plasma renin activity in humans .
2571299	0	Atrial_natriuretic_factor	0,25	renin	59,64	Atrial natriuretic factor	renin	608289(Tax:9615)	403838(Tax:9615)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|stimulation stimulation|nmod|release release|compound|END_ENTITY	Atrial_natriuretic_factor suppresses neural stimulation of renin release in dogs .
1533606	0	Atrial_natriuretic_peptide	0,26	ANP	114,117	Atrial natriuretic peptide	ANP	4878	4878	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Atrial_natriuretic_peptide -LRB- ANP -RRB- in chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- : the relationship between plasma ANP and lung function .
8550616	0	Atrial_natriuretic_peptide	0,26	MKP-1	53,58	Atrial natriuretic peptide	MKP-1	24602(Tax:10116)	114856(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Atrial_natriuretic_peptide induces the expression of MKP-1 , a mitogen-activated protein kinase phosphatase , in glomerular mesangial cells .
2948755	0	Atrial_natriuretic_peptide	0,26	angiotensin_II	61,75	Atrial natriuretic peptide	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Atrial_natriuretic_peptide inhibits the effect of endogenous angiotensin_II on plasma aldosterone in conscious sodium-depleted rats .
9387850	0	Atrial_natriuretic_peptide	0,26	angiotensin_II	75,89	Atrial natriuretic peptide	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Atrial_natriuretic_peptide negatively modulates the stimulatory effects of angiotensin_II on tuberoinfundibular dopaminergic neuronal activity .
1836994	0	Atrial_natriuretic_peptide	0,26	insulin-degrading_enzyme	70,94	Atrial natriuretic peptide	insulin-degrading enzyme	24602(Tax:10116)	25700(Tax:10116)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Atrial_natriuretic_peptide -LRB- ANP -RRB- is a high-affinity substrate for rat insulin-degrading_enzyme .
2535241	0	Atrial_natriuretic_peptide	0,26	renin	35,40	Atrial natriuretic peptide	renin	4878	5972	Gene	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	Atrial_natriuretic_peptide , plasma renin activity , plasma volume , systemic vascular resistance and cardiac output in patients with cirrhosis .
2949634	0	Atrial_natriuretic_peptide	0,26	renin	34,39	Atrial natriuretic peptide	renin	24602(Tax:10116)	24715(Tax:10116)	Gene	Gene	blocks|nsubj|START_ENTITY blocks|dobj|response response|compound|END_ENTITY	Atrial_natriuretic_peptide blocks renin response to renal_hypotension .
9658401	0	Atrial_natriuretic_peptide	0,26	steroidogenic_acute_regulatory	52,82	Atrial natriuretic peptide	steroidogenic acute regulatory	281355(Tax:9913)	281507(Tax:9913)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Atrial_natriuretic_peptide inhibits calcium-induced steroidogenic_acute_regulatory protein gene transcription in adrenal_glomerulosa cells .
13680156	0	Ats1p	25,30	Nap1p	46,51	Ats1p	Nap1p	851213(Tax:4932)	853922(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Saccharomyces_cerevisiae Ats1p interacts with Nap1p , a cytoplasmic protein that controls bud morphogenesis .
17764659	0	Atxn3	26,31	ataxin-3	33,41	Atxn3	ataxin-3	110616(Tax:10090)	110616(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Inactivation of the mouse Atxn3 -LRB- ataxin-3 -RRB- gene increases protein ubiquitination .
20713507	0	Aubergine	61,70	Tudor	74,79	Aubergine	Tudor	34524(Tax:7227)	37417(Tax:7227)	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for methylarginine-dependent recognition of Aubergine by Tudor .
17925329	0	Aurora-A	58,66	ASAP	0,4	Aurora-A	ASAP	6790	79884	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A : phosphorylation on Ser625 is essential to spindle formation and mitosis .
13678582	0	Aurora-A	0,8	Ajuba	55,60	Aurora-A	Ajuba	6790	84962	Gene	Gene	activator|amod|START_ENTITY activator|appos|END_ENTITY	Aurora-A and an interacting activator , the LIM protein Ajuba , are required for mitotic commitment in human cells .
21402878	0	Aurora-A	27,35	Ajuba	11,16	Aurora-A	Ajuba	41446(Tax:7227)	32351(Tax:7227)	Gene	Gene	activator|amod|START_ENTITY activator|nsubj|END_ENTITY	Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome .
16894566	0	Aurora-A	0,8	Akt	68,71	Aurora-A	Akt	6790	207	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Aurora-A induces cell survival and chemoresistance by activation of Akt through a p53-dependent manner in ovarian_cancer cells .
16890155	0	Aurora-A	33,41	Bora	71,75	Aurora-A	Bora	41446(Tax:7227)	40031(Tax:7227)	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|END_ENTITY	Mitotic activation of the kinase Aurora-A requires its binding partner Bora .
16082213	0	Aurora-A	26,34	CDC25B	0,6	Aurora-A	CDC25B	6790	994	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage .
14667408	0	Aurora-A	26,34	CENP-A	0,6	Aurora-A	CENP-A	6790	1058	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function .
19028417	0	Aurora-A	0,8	Cyclin_B1	24,33	Aurora-A	Cyclin B1	6790	891	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Aurora-A interacts with Cyclin_B1 and enhances its stability .
18790738	0	Aurora-A	32,40	Fas-associated_factor-1	64,87	Aurora-A	Fas-associated factor-1	6790	11124	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated_factor-1 .
22513362	0	Aurora-A	15,23	Fbxw7	44,49	Aurora-A	Fbxw7	20878(Tax:10090)	50754(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development .
22483753	0	Aurora-A	22,30	IQGAP1	0,6	Aurora-A	IQGAP1	6790	8826	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer .
25428915	0	Aurora-A	0,8	PTEN	96,100	Aurora-A	PTEN	6790	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA -21 / PTEN signaling pathway .
22513362	0	Aurora-A	15,23	Pten	0,4	Aurora-A	Pten	20878(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development .
17563743	0	Aurora-A	15,23	RASSF1A	39,46	Aurora-A	RASSF1A	6790	11186	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation .
16926177	0	Aurora-A	24,32	STK15	17,22	Aurora-A	STK15	6790	6790	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of STK15 -LRB- Aurora-A -RRB- gene and lung_cancer risk in Caucasians .
14580337	0	Aurora-A	20,28	TPX2	43,47	Aurora-A	TPX2	6790	22974	Gene	Gene	basis|nmod|START_ENTITY activation|nsubj|basis activation|nmod|END_ENTITY	Structural basis of Aurora-A activation by TPX2 at the mitotic spindle .
20713353	0	Aurora-A	55,63	androgen_receptor	34,51	Aurora-A	androgen receptor	6790	367	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of androgen_receptor by Aurora-A .
21821029	0	Aurora-A	0,8	hnRNPK	24,30	Aurora-A	hnRNPK	6790	3190	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53 .
22621899	0	Aurora-A_kinase	25,40	AURKA	42,47	Aurora-A kinase	AURKA	6790	6790	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Calmodulin activation of Aurora-A_kinase -LRB- AURKA -RRB- is required during ciliary disassembly and in mitosis .
15147269	0	Aurora-A_kinase	61,76	Lats2	24,29	Aurora-A kinase	Lats2	6790	26524	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The centrosomal protein Lats2 is a phosphorylation target of Aurora-A_kinase .
17060449	0	Aurora-A_kinase	25,40	NDEL1	0,5	Aurora-A kinase	NDEL1	6790	81565	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	NDEL1 phosphorylation by Aurora-A_kinase is essential for centrosomal maturation , separation , and TACC3 recruitment .
17935280	0	Aurora-A_kinase	0,15	NF-kappaB	26,35	Aurora-A kinase	NF-kappaB	6790	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Aurora-A_kinase regulates NF-kappaB activity : lessons from combination studies .
20047310	0	Aurora-A_kinase	84,99	pVHL	68,72	Aurora-A kinase	pVHL	6790	7428	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Experimental and computational studies indicate specific binding of pVHL protein to Aurora-A_kinase .
20593489	0	Aurora-B	69,77	CYLD	18,22	Aurora-B	CYLD	9212	1540	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B .
25197332	0	Aurora-B	71,79	Let-7g	0,6	Aurora-B	Let-7g	9212	406890	Gene	Gene	reverses|nmod|START_ENTITY reverses|nsubj|END_ENTITY	Let-7g reverses malignant phenotype of osteosarcoma cells by targeting Aurora-B .
25997616	0	Aurora-B	75,83	Let-7i	0,6	Aurora-B	Let-7i	9212	406891	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Let-7i inhibits the malignant phenotype of osteosarcoma cells by targeting Aurora-B .
17215513	0	Aurora-B	0,8	NSUN2	41,46	Aurora-B	NSUN2	9212	54888	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Aurora-B regulates RNA methyltransferase NSUN2 .
12458200	0	Aurora-B	0,8	vimentin	48,56	Aurora-B	vimentin	9212	7431	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process .
18628459	0	Aurora_A	14,22	Aurora_B	32,40	Aurora A	Aurora B	6790	9212	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of Aurora_A -LRB- but not Aurora_B -RRB- is predictive of survival in breast_cancer .
19402633	0	Aurora_A	36,44	Aurora_B	96,104	Aurora A	Aurora B	6790	9212	Gene	Gene	class|nmod|START_ENTITY inhibitors|nsubj|class inhibitors|nmod|selectivity selectivity|nmod|END_ENTITY	A class of 2,4-bisanilinopyrimidine Aurora_A inhibitors with unusually high selectivity against Aurora_B .
19494039	0	Aurora_A	82,90	Aurora_B	131,139	Aurora A	Aurora B	6790	9212	Gene	Gene	transforms|dobj|START_ENTITY transforms|nmod|END_ENTITY	Molecular distinctions between Aurora_A and B : a single residue change transforms Aurora_A into correctly localized and functional Aurora_B .
23592782	0	Aurora_A	117,125	Bora	135,139	Aurora A	Bora	6790	79866	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Ataxia_telangiectasia-mutated - _ and_Rad3-related_protein regulates the DNA damage-induced G2/M checkpoint through the Aurora_A cofactor Bora protein .
19074838	0	Aurora_A	40,48	EWS-Fli1	0,8	Aurora A	EWS-Fli1	6790	2130	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	EWS-Fli1 up-regulates expression of the Aurora_A and Aurora_B kinases .
18321990	0	Aurora_A	0,8	HURP	35,39	Aurora A	HURP	6790	9787	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Aurora_A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain .
19390576	0	Aurora_A	28,36	Polo-like_kinase-1	0,18	Aurora A	Polo-like kinase-1	6790	5347	Gene	Gene	destruction|compound|START_ENTITY controls|dobj|destruction controls|nsubj|END_ENTITY	Polo-like_kinase-1 controls Aurora_A destruction by activating APC/C-Cdh 1 .
21187329	0	Aurora_A	109,117	TPX2	141,145	Aurora A	TPX2	6790	22974	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Protein_phosphatase_6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora_A bound to its activator TPX2 .
26713495	0	Aurora_A	0,8	WD40-repeat_protein_62	28,50	Aurora A	WD40-repeat protein 62	20878(Tax:10090)	233064(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Aurora_A phosphorylation of WD40-repeat_protein_62 in mitotic spindle regulation .
26124292	0	Aurora_A	39,47	mTOR	20,24	Aurora A	mTOR	6790	21977(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Mio depletion links mTOR regulation to Aurora_A and Plk1 activation at mitotic centrosomes .
22396649	0	Aurora_A	41,49	p53	72,75	Aurora A	p53	6790	7157	Gene	Gene	expression|compound|START_ENTITY expression|acl|promote promote|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Kaposi 's _ sarcoma herpesvirus upregulates Aurora_A expression to promote p53 phosphorylation and ubiquitylation .
22894933	0	Aurora_A	25,33	p53	0,3	Aurora A	p53	6790	7157	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p53 negatively regulates Aurora_A via both transcriptional and posttranslational regulation .
18628459	0	Aurora_B	32,40	Aurora_A	14,22	Aurora B	Aurora A	9212	6790	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of Aurora_A -LRB- but not Aurora_B -RRB- is predictive of survival in breast_cancer .
19402633	0	Aurora_B	96,104	Aurora_A	36,44	Aurora B	Aurora A	9212	6790	Gene	Gene	selectivity|nmod|START_ENTITY inhibitors|nmod|selectivity inhibitors|nsubj|class class|nmod|END_ENTITY	A class of 2,4-bisanilinopyrimidine Aurora_A inhibitors with unusually high selectivity against Aurora_B .
19494039	0	Aurora_B	131,139	Aurora_A	82,90	Aurora B	Aurora A	9212	6790	Gene	Gene	transforms|nmod|START_ENTITY transforms|dobj|END_ENTITY	Molecular distinctions between Aurora_A and B : a single residue change transforms Aurora_A into correctly localized and functional Aurora_B .
16311121	0	Aurora_B	95,103	Aurora_kinases_A_and_B	14,36	Aurora B	Aurora kinases A and B	9212	6790;9212	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of Aurora_kinases_A_and_B in normal , hyperplastic , and malignant human endometrium : Aurora_B as a predictor for poor prognosis in endometrial_carcinoma .
23712260	0	Aurora_B	0,8	EB3	29,32	Aurora B	EB3	9212	22924	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Aurora_B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis .
15866179	0	Aurora_B	13,21	INCENP	36,42	Aurora B	INCENP	9212	3619	Gene	Gene	Mechanism|nmod|START_ENTITY activation|nsubj|Mechanism activation|nmod|END_ENTITY	Mechanism of Aurora_B activation by INCENP and inhibition by hesperadin .
18767990	0	Aurora_B	32,40	INCENP	22,28	Aurora B	INCENP	9212	3619	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	The catalytic role of INCENP in Aurora_B activation and the kinetic mechanism of Aurora_B / INCENP .
18767990	0	Aurora_B	32,40	INCENP	90,96	Aurora B	INCENP	9212	3619	Gene	Gene	activation|compound|START_ENTITY INCENP|nmod|activation role|nmod|INCENP END_ENTITY|nsubj|role	The catalytic role of INCENP in Aurora_B activation and the kinetic mechanism of Aurora_B / INCENP .
14960279	0	Aurora_B	0,8	MCAK	19,23	Aurora B	MCAK	9212	11004	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Aurora_B regulates MCAK at the mitotic centromere .
14972678	0	Aurora_B	0,8	MCAK	36,40	Aurora B	MCAK	398457(Tax:8355)	380006(Tax:8355)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Aurora_B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity .
15120087	0	Aurora_B	32,40	MCAK	9,13	Aurora B	MCAK	9212	11004	Gene	Gene	aura|nmod|START_ENTITY END_ENTITY|nmod|aura	Mitosis : MCAK under the aura of Aurora_B .
16950107	0	Aurora_B	0,8	MCAK	71,75	Aurora B	MCAK	9212	11004	Gene	Gene	enriched|nsubjpass|START_ENTITY enriched|nmod|sites sites|acl:relcl|regulates regulates|dobj|END_ENTITY	Aurora_B is enriched at merotelic attachment sites , where it regulates MCAK .
24291095	0	Aurora_B	0,8	MCAK	18,22	Aurora B	MCAK	9212	11004	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Aurora_B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association .
22732840	0	Aurora_B	47,55	Mps1	0,4	Aurora B	Mps1	9212	219972	Gene	Gene	accumulation|nmod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	Mps1 promotes rapid centromere accumulation of Aurora_B .
20864540	0	Aurora_B	0,8	Nlp	36,39	Aurora B	Nlp	9212	22981	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Aurora_B interaction of centrosomal Nlp regulates cytokinesis .
20889715	0	Aurora_B	37,45	PP2A	55,59	Aurora B	PP2A	9212	5524	Gene	Gene	Sgo2|nmod|START_ENTITY Phosphorylation|nmod|Sgo2 recruits|nsubj|Phosphorylation recruits|dobj|END_ENTITY	Phosphorylation of mammalian Sgo2 by Aurora_B recruits PP2A and MCAK to centromeres .
25892238	0	Aurora_B	21,29	PP2A	50,54	Aurora B	PP2A	9212	5524	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Shugoshin-1 Balances Aurora_B Kinase Activity via PP2A to Promote Chromosome Bi-orientation .
26906715	0	Aurora_B	26,34	PP2A	10,14	Aurora B	PP2A	9212	5524	Gene	Gene	activity|compound|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	IK-guided PP2A suppresses Aurora_B activity in the interphase of tumor cells .
25892238	0	Aurora_B	21,29	Shugoshin-1	0,11	Aurora B	Shugoshin-1	9212	151648	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Shugoshin-1 Balances Aurora_B Kinase Activity via PP2A to Promote Chromosome Bi-orientation .
26697838	0	Aurora_B	21,29	Skp2	0,4	Aurora B	Skp2	9212	6502	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Skp2 is required for Aurora_B activation in cell mitosis and spindle checkpoint .
23901111	0	Aurora_B	0,8	Wapl	26,30	Aurora B	Wapl	9212	23063	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|compound|END_ENTITY	Aurora_B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin .
21397845	0	Aurora_B	0,8	mDia3	26,31	Aurora B	mDia3	9212	54004(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Aurora_B regulates formin mDia3 in achieving metaphase chromosome alignment .
17567953	0	Aurora_B	0,8	mitotic_centromere-associated_kinesin	42,79	Aurora B	mitotic centromere-associated kinesin	9212	11004	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|nmod|END_ENTITY	Aurora_B phosphorylates multiple sites on mitotic_centromere-associated_kinesin to spatially and temporally regulate its function .
24104968	0	Aurora_kinase_A	0,15	AURKA	17,22	Aurora kinase A	AURKA	6790	6790	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Aurora_kinase_A -LRB- AURKA -RRB- expression in colorectal_cancer_liver_metastasis is associated with poor prognosis .
25900902	0	Aurora_kinase_A	20,35	AURKA	37,42	Aurora kinase A	AURKA	6790	6790	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Prognostic value of Aurora_kinase_A -LRB- AURKA -RRB- expression among solid tumor patients : a systematic review and meta-analysis .
23686525	0	Aurora_kinase_A	68,83	CD38	8,12	Aurora kinase A	CD38	6790	952	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	CD34 ___ / CD38 acute_myelogenous_leukemia cells aberrantly express Aurora_kinase_A .
18663361	0	Aurora_kinase_A	46,61	Pituitary_tumor_transforming_gene_1	0,35	Aurora kinase A	Pituitary tumor transforming gene 1	6790	9232	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Pituitary_tumor_transforming_gene_1 regulates Aurora_kinase_A activity .
16311121	0	Aurora_kinases_A_and_B	14,36	Aurora_B	95,103	Aurora kinases A and B	Aurora B	6790;9212	9212	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of Aurora_kinases_A_and_B in normal , hyperplastic , and malignant human endometrium : Aurora_B as a predictor for poor prognosis in endometrial_carcinoma .
10856287	0	Aut7p	101,106	GATE-16	13,20	Aut7p	GATE-16	852200(Tax:4932)	11345	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of GATE-16 , membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p .
25398668	0	Autism_Susceptibility_Candidate_2	41,74	AUTS2	76,81	Autism Susceptibility Candidate 2	AUTS2	26053	26053	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	The Evidence for the Contribution of the Autism_Susceptibility_Candidate_2 -LRB- AUTS2 -RRB- Gene in Heroin Dependence Susceptibility .
12209971	0	Autocrine_motility_factor	0,25	vascular_endothelial_growth_factor_receptor	62,105	Autocrine motility factor	vascular endothelial growth factor receptor	2821	3791	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Autocrine_motility_factor secreted by tumor cells upregulates vascular_endothelial_growth_factor_receptor -LRB- Flt-1 -RRB- expression in endothelial cells .
12398240	0	Autoimmune_regulator	0,20	AIRE	22,26	Autoimmune regulator	AIRE	326	326	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Autoimmune_regulator -LRB- AIRE -RRB- gene on chromosome 21 : implications for autoimmune_polyendocrinopathy-candidiasis-ectodermal_dystrophy -LRB- APECED -RRB- any more common manifestations of endocrine autoimmunity .
25385288	0	Autophagy-linked_FYVE	0,21	Alfy	31,35	Autophagy-linked FYVE	Alfy	72145(Tax:10090)	72145(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Autophagy-linked_FYVE protein -LRB- Alfy -RRB- promotes autophagic removal of misfolded proteins involved in amyotrophic_lateral_sclerosis -LRB- ALS -RRB- .
26997151	0	Autotaxin	66,75	ATX	77,80	Autotaxin	ATX	5168	5168	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Computer Aided Drug Design Approaches for Identification of Novel Autotaxin -LRB- ATX -RRB- Inhibitors .
21314984	0	Autotaxin	0,9	TSA	24,27	Autotaxin	ATX	5168	5168	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis .
19212832	0	Autotaxin	0,9	matrix_metalloproteinase-3	37,63	Autotaxin	matrix metalloproteinase-3	5168	4314	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Autotaxin promotes the expression of matrix_metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells .
17013094	0	Autotaxin	0,9	urokinase-type_plasminogen_activator	21,57	Autotaxin	urokinase-type plasminogen activator	5168	5328	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Autotaxin stimulates urokinase-type_plasminogen_activator expression through phosphoinositide_3-kinase-Akt-nuclear -LSB- corrected -RSB- factor kappa B signaling cascade in human melanoma cells .
10949025	0	Aven	0,4	Bcl-xL	53,59	Aven	Bcl-xL	57099	598	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Aven , a novel inhibitor of caspase activation , binds Bcl-xL and Apaf-1 .
20619636	0	Aven	0,4	Bcl-xL	56,62	Aven	Bcl-xL	57099	598	Gene	Gene	blocks|nsubj|START_ENTITY blocks|advcl|stabilising stabilising|dobj|END_ENTITY	Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL .
22388353	0	Aven	27,31	Cathepsin_D	46,57	Aven	Cathepsin D	57099	1509	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	The Apaf-1-binding protein Aven is cleaved by Cathepsin_D to unleash its anti-apoptotic potential .
26267306	0	Aven	0,4	G-quadruplexes	24,38	Aven	G-quadruplexes	57099	57827	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Aven recognition of RNA G-quadruplexes regulates translation of the mixed_lineage_leukemia protooncogenes .
26267306	0	Aven	0,4	G-quadruplexes	24,38	Aven	G-quadruplexes	57099	57827	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Aven recognition of RNA G-quadruplexes regulates translation of the mixed_lineage_leukemia protooncogenes .
3732509	0	Avidin	0,6	pyruvate_carboxylase	59,79	Avidin	pyruvate carboxylase	396260(Tax:9031)	374263(Tax:9031)	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Avidin as a probe of the conformational changes induced in pyruvate_carboxylase by acetyl-CoA and pyruvate .
26299644	0	Avpr1a	55,61	OXTR	95,99	Avpr1a	OXTR	452038(Tax:9598)	738742(Tax:9598)	Gene	Gene	vasopressin|dep|START_ENTITY variation|amod|vasopressin variation|appos|END_ENTITY	Chimpanzee sociability is associated with vasopressin -LRB- Avpr1a -RRB- but not oxytocin_receptor gene -LRB- OXTR -RRB- variation .
9566905	0	Axil	0,4	Axin	22,26	Axil	Axin	447702(Tax:8355)	398097(Tax:8355)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Axil , a member of the Axin family , interacts with both glycogen_synthase_kinase_3beta and beta-catenin and inhibits axis formation of Xenopus embryos .
9566905	0	Axil	0,4	glycogen_synthase_kinase_3beta	55,85	Axil	glycogen synthase kinase 3beta	447702(Tax:8355)	399097(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Axil , a member of the Axin family , interacts with both glycogen_synthase_kinase_3beta and beta-catenin and inhibits axis formation of Xenopus embryos .
9566905	0	Axin	22,26	Axil	0,4	Axin	Axil	398097(Tax:8355)	447702(Tax:8355)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Axil , a member of the Axin family , interacts with both glycogen_synthase_kinase_3beta and beta-catenin and inhibits axis formation of Xenopus embryos .
17922036	0	Axin	82,86	Disabled-2	26,36	Axin	Disabled-2	8312	1601	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|nmod|END_ENTITY	The inhibitory effects of Disabled-2 -LRB- Dab2 -RRB- on Wnt signaling are mediated through Axin .
16981698	0	Axin	27,31	GSK3beta	101,109	Axin	GSK3beta	8312	2932	Gene	Gene	domain|compound|START_ENTITY homologous|nmod|domain homologous|nmod|regulator regulator|nmod|END_ENTITY	GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta .
16981698	0	Axin	27,31	GSK3beta	32,40	Axin	GSK3beta	8312	2932	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta .
19850033	0	Axin	88,92	GSK3beta	115,123	Axin	GSK3beta	43565(Tax:7227)	31248(Tax:7227)	Gene	Gene	residues|nmod|START_ENTITY requirements|nmod|residues reveals|dobj|requirements reveals|nmod|interactions interactions|nmod|END_ENTITY	In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin .
10428961	0	Axin	0,4	LEF-1	92,97	Axin	LEF-1	8312	51176	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Axin and Frat1 interact with dvl and GSK , bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 .
11336703	0	Axin	60,64	Low-density_lipoprotein_receptor-related_protein-5	0,50	Axin	Low-density lipoprotein receptor-related protein-5	8312	4041	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Low-density_lipoprotein_receptor-related_protein-5 binds to Axin and regulates the canonical Wnt signaling pathway .
10023673	0	Axin	0,4	beta-catenin	45,57	Axin	beta-catenin	8312	1499	Gene	Gene	prevents|nsubj|START_ENTITY prevents|dobj|accumulation accumulation|nmod|END_ENTITY	Axin prevents Wnt-3a-induced accumulation of beta-catenin .
10698523	0	Axin	154,158	beta-catenin	99,111	Axin	beta-catenin	8312	1499	Gene	Gene	complexed|nmod|START_ENTITY phosphatase_2A|acl|complexed phosphatase_2A|compound|END_ENTITY	GSK-3beta-dependent phosphorylation of adenomatous_polyposis_coli gene product can be modulated by beta-catenin and protein phosphatase_2A complexed with Axin .
10722668	0	Axin	97,101	beta-catenin	19,31	Axin	beta-catenin	8312	1499	Gene	Gene	requires|nmod|START_ENTITY requires|nsubj|Down-regulation Down-regulation|nmod|APC APC|amod|END_ENTITY	Down-regulation of beta-catenin by the colorectal_tumor suppressor APC requires association with Axin and beta-catenin .
14981260	0	Axin	33,37	beta-catenin	76,88	Axin	beta-catenin	43565(Tax:7227)	31151(Tax:7227)	Gene	Gene	shuttling|nmod|START_ENTITY regulates|nsubj|shuttling regulates|dobj|localization localization|nmod|END_ENTITY	Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin .
15063782	0	Axin	55,59	beta-catenin	65,77	Axin	beta-catenin	8312	1499	Gene	Gene	interaction|nmod|START_ENTITY regulates|dobj|interaction regulates|nmod|END_ENTITY	Cyclin-dependent_kinase_2 regulates the interaction of Axin with beta-catenin .
15067328	0	Axin	70,74	beta-catenin	56,68	Axin	beta-catenin	8312	1499	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	Immunohistochemical analysis and mutational analyses of beta-catenin , Axin family and APC genes in hepatocellular_carcinomas .
17374607	0	Axin	0,4	beta-catenin	83,95	Axin	beta-catenin	8312	1499	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|degradation degradation|nmod|END_ENTITY	Axin inhibits extracellular_signal-regulated_kinase pathway by Ras degradation via beta-catenin .
18217212	0	Axin	128,132	beta-catenin	94,106	Axin	beta-catenin	8312	1499	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of beta-catenin via up-regulation of Axin .
18509060	0	Axin	56,60	beta-catenin	113,125	Axin	beta-catenin	398097(Tax:8355)	399274(Tax:8355)	Gene	Gene	degradation|compound|START_ENTITY signal|nmod|degradation transduces|dobj|signal transduces|advcl|inhibiting inhibiting|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3 's phosphorylation of beta-catenin .
19565571	0	Axin	57,61	beta-catenin	17,29	Axin	beta-catenin	398097(Tax:8355)	399274(Tax:8355)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Threonine Threonine|nmod|END_ENTITY	Threonine 393 of beta-catenin regulates interaction with Axin .
20122174	0	Axin	0,4	beta-catenin	43,55	Axin	beta-catenin	8312	1499	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|transcription transcription|nmod|END_ENTITY	Axin downregulates TCF-4 transcription via beta-catenin , but not p53 , and inhibits the proliferation and invasion of lung_cancer cells .
20719112	0	Axin	17,21	beta-catenin	57,69	Axin	beta-catenin	8312	1499	Gene	Gene	Expressions|compound|START_ENTITY Expressions|nmod|END_ENTITY	-LSB- Transfection of Axin Gene Down-regulates Expressions of beta-catenin and TCF-4 and Inhibits the Proliferation and Invasive Ability of Lung_Cancer Cells . -RSB- .
9734785	0	Axin	0,4	beta-catenin	65,77	Axin	beta-catenin	8312	1499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Axin , an inhibitor of the Wnt signalling pathway , interacts with beta-catenin , GSK-3beta and APC and reduces the beta-catenin level .
15262978	0	Axin	87,91	coiled-coil-DIX1	23,39	Axin	coiled-coil-DIX1	8312	85458	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms .
11707456	0	Axin	22,26	glycogen_synthase_kinase-3	54,80	Axin	glycogen synthase kinase-3	398097(Tax:8355)	779056(Tax:8355)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the Axin and Frat binding region of glycogen_synthase_kinase-3 .
12421363	0	Axin	0,4	glycogen_synthase_kinase_3beta	47,77	Axin	glycogen synthase kinase 3beta	8312	2932	Gene	Gene	affects|nsubj|START_ENTITY affects|nmod|END_ENTITY	Axin negatively affects tau phosphorylation by glycogen_synthase_kinase_3beta .
10698523	0	Axin	154,158	phosphatase_2A	124,138	Axin	phosphatase 2A	8312	5524	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	GSK-3beta-dependent phosphorylation of adenomatous_polyposis_coli gene product can be modulated by beta-catenin and protein phosphatase_2A complexed with Axin .
20128690	0	Axin1	35,40	MAP3K1	0,6	Axin1	MAP3K1	8312	4214	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway .
26191213	0	Axin2	74,79	miR-107	0,7	Axin2	miR-107	8313	406901	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	miR-107 promotes hepatocellular_carcinoma cell proliferation by targeting Axin2 .
19633687	0	Axl	0,3	Axl	57,60	Axl	Axl	558	558	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Axl as a potential therapeutic target in cancer : role of Axl in tumor growth , metastasis and angiogenesis .
19633687	0	Axl	57,60	Axl	0,3	Axl	Axl	558	558	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Axl as a potential therapeutic target in cancer : role of Axl in tumor growth , metastasis and angiogenesis .
9287338	0	Axl	72,75	GAS6	0,4	Axl	GAS6	558	2621	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing adhesion|nmod|cells mediates|dobj|adhesion mediates|nsubj|END_ENTITY	GAS6 mediates adhesion of cells expressing the receptor_tyrosine_kinase Axl .
9357964	0	Axl	20,23	GAS6	0,4	Axl	GAS6	558	2621	Gene	Gene	receptors|compound|START_ENTITY ligand|nmod|receptors END_ENTITY|appos|ligand	GAS6 , the ligand of Axl and Rse receptors , is expressed in hematopoietic tissue but lacks mitogenic activity .
11290560	0	Axl	52,55	Gas6	0,4	Axl	Gas6	558	2621	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis .
15380678	0	Axl	59,62	Gas6	0,4	Axl	Gas6	308444(Tax:10116)	58935(Tax:10116)	Gene	Gene	kinase|compound|START_ENTITY role|nmod|kinase apoptosis|dep|role apoptosis|amod|END_ENTITY	Gas6 inhibits apoptosis in vascular smooth muscle : role of Axl kinase and Akt .
15605394	0	Axl	75,78	Gas6	0,4	Axl	Gas6	558	2621	Gene	Gene	receptor|compound|START_ENTITY expressing|dobj|receptor lines|acl|expressing induces|dobj|lines induces|nsubj|END_ENTITY	Gas6 induces proliferation_in_prostate_carcinoma cell lines expressing the Axl receptor .
15733062	0	Axl	15,18	Gas6	0,4	Axl	Gas6	558	2621	Gene	Gene	enhance|nsubj|START_ENTITY receptors|ccomp|enhance receptors|nsubj|END_ENTITY	Gas6 receptors Axl , Sky and Mer enhance platelet activation and regulate thrombotic responses .
15958209	0	Axl	41,44	Gas6	11,15	Axl	Gas6	558	2621	Gene	Gene	ubiquitination|compound|START_ENTITY Effects|nmod|ubiquitination Effects|nmod|END_ENTITY	Effects of Gas6 and hydrogen_peroxide in Axl ubiquitination and downregulation .
16227584	0	Axl	8,11	Gas6	74,78	Axl	Gas6	26362(Tax:10090)	14456(Tax:10090)	Gene	Gene	generated|nsubjpass|START_ENTITY generated|nmod|END_ENTITY	Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum .
16285961	0	Axl	56,59	Gas6	23,27	Axl	Gas6	308444(Tax:10116)	58935(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|protein protein|amod|END_ENTITY	Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat .
17064312	0	Axl	56,59	Gas6	0,4	Axl	Gas6	558	2621	Gene	Gene	subfamily|compound|START_ENTITY ligands|nmod|subfamily ligands|nsubj|END_ENTITY	Gas6 and protein S. Vitamin_K-dependent ligands for the Axl receptor tyrosine kinase subfamily .
19541935	0	Axl	25,28	Gas6	90,94	Axl	Gas6	558	2621	Gene	Gene	Up-regulation|nmod|START_ENTITY correlates|nsubj|Up-regulation correlates|nmod|END_ENTITY	Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple_sclerosis_lesions .
20088931	0	Axl	58,61	Gas6	0,4	Axl	Gas6	558	2621	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubjpass|END_ENTITY	Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood .
20546121	0	Axl	37,40	Gas6	21,25	Axl	Gas6	558	2621	Gene	Gene	_|nsubj|START_ENTITY _|advcl|Potentiating Potentiating|dobj|role role|nmod|END_ENTITY	Potentiating role of Gas6 and Tyro3 , Axl and Mer _ -LRB- TAM -RRB- _ receptors in human and murine platelet activation and thrombus stabilization .
21501828	0	Axl	110,113	Gas6	26,30	Axl	Gas6	558	2621	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|phosphatidylserine phosphatidylserine|compound|END_ENTITY	The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry .
7867073	0	Axl	88,91	Gas6	55,59	Axl	Gas6	558	2621	Gene	Gene	family|compound|START_ENTITY ligands|nmod|family ligands|nsubj|S S|appos|END_ENTITY	The anticoagulation factor protein S and its relative , Gas6 , are ligands for the Tyro_3 / Axl family of receptor tyrosine kinases .
18346204	0	Axl	10,13	Grb2	23,27	Axl	Grb2	26362(Tax:10090)	14784(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	In brain , Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase ; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation .
7867073	0	Axl	88,91	Tyro_3	81,87	Axl	Tyro 3	558	7301	Gene	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	The anticoagulation factor protein S and its relative , Gas6 , are ligands for the Tyro_3 / Axl family of receptor tyrosine kinases .
23298489	0	Axl	122,125	YES-associated_protein_1	0,24	Axl	YES-associated protein 1	558	10413	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	YES-associated_protein_1 promotes adenocarcinoma growth and metastasis through activation of the receptor_tyrosine_kinase Axl .
9326369	0	Axl	86,89	gas6	17,21	Axl	gas6	558	2621	Gene	Gene	kinase|compound|START_ENTITY responsible|nmod|kinase activation|amod|responsible release|nmod|activation allows|dobj|release allows|nsubj|product product|nmod|variant variant|amod|END_ENTITY	The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation .
22844123	0	Axl	94,97	oncostatin_M	27,39	Axl	oncostatin M	558	5008	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E induces oncostatin_M expression in human chronic wound macrophages through Axl receptor_tyrosine_kinase pathway .
18522535	0	Axl	35,38	receptor_tyrosine_kinase	10,34	Axl	receptor tyrosine kinase	558	5979	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The human receptor_tyrosine_kinase Axl gene -- promoter characterization and regulation of constitutive expression by Sp1 , Sp3 and CpG methylation .
21135257	0	Axl	35,38	receptor_tyrosine_kinase	10,34	Axl	receptor tyrosine kinase	558	5979	Gene	Gene	active|nsubj|START_ENTITY END_ENTITY|ccomp|active	The novel receptor_tyrosine_kinase Axl is constitutively active in B-cell_chronic_lymphocytic_leukemia and acts as a docking site of nonreceptor kinases : implications for therapy .
22844123	0	Axl	94,97	receptor_tyrosine_kinase	98,122	Axl	receptor tyrosine kinase	558	5979	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Prostaglandin_E induces oncostatin_M expression in human chronic wound macrophages through Axl receptor_tyrosine_kinase pathway .
9130617	0	Axl	31,34	receptor_tyrosine_kinase	38,62	Axl	receptor tyrosine kinase	558	5979	Gene	Gene	role|nmod|START_ENTITY progress|nmod|role progress|appos|END_ENTITY	Recent progress on the role of Axl , a receptor_tyrosine_kinase , in malignant_transformation_of_myeloid_leukemias .
11861604	0	B-1	25,28	CD5	61,64	B-1	CD5	931	921	Gene	Gene	cells|amod|START_ENTITY Origins|nmod|cells Origins|nmod|notes notes|nmod|role role|nmod|END_ENTITY	Origins and functions of B-1 cells with notes on the role of CD5 .
12070149	0	B-1	16,19	CD5	11,14	B-1	CD5	931	921	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Peritoneal CD5 + B-1 cells have signaling properties similar to tolerant B cells .
1377947	0	B-1	53,56	CD5	58,61	B-1	CD5	931	921	Gene	Gene	cells|amod|START_ENTITY cells|appos|B B|compound|END_ENTITY	The ontogeny and functional characteristics of human B-1 -LRB- CD5 + B -RRB- cells .
20728949	0	B-2	22,25	LRRK2	0,5	B-2	LRRK2	12062(Tax:10090)	66725(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	LRRK2 is expressed in B-2 but not in B-1 B cells , and downregulated by cellular activation .
2312735	0	B-31	140,144	apolipoprotein_B	122,138	B-31	apolipoprotein B	9595	338	Gene	Gene	gene|appos|START_ENTITY gene|acl:relcl|results results|nmod|species species|nmod|END_ENTITY	Familial_hypobetalipoproteinemia caused by a mutation in the apolipoprotein_B gene that results in a truncated species of apolipoprotein_B -LRB- B-31 -RRB- .
2312735	0	B-31	140,144	apolipoprotein_B	61,77	B-31	apolipoprotein B	9595	338	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Familial_hypobetalipoproteinemia caused by a mutation in the apolipoprotein_B gene that results in a truncated species of apolipoprotein_B -LRB- B-31 -RRB- .
10640691	0	B-50	99,103	GAP-43	104,110	B-50	GAP-43	14432(Tax:10090)	14432(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transgenic expression of B-50 / GAP-43 in mature olfactory neurons triggers downregulation of native B-50 / GAP-43 expression in immature olfactory neurons .
1840422	0	B-50	38,42	GAP-43	43,49	B-50	GAP-43	2596	2596	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of the growth-associated protein B-50 / GAP-43 in neuronal plasticity .
2466968	0	B-50	61,65	GAP-43	53,59	B-50	GAP-43	2596	2596	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the growth-associated phosphoprotein GAP-43 -LRB- B-50 , F1 -RRB- in the human cerebral cortex .
2926454	0	B-50	44,48	GAP-43	50,56	B-50	GAP-43	2596	2596	Gene	Gene	light|nmod|START_ENTITY light|appos|END_ENTITY	A light and electron microscopical study of B-50 -LRB- GAP-43 -RRB- in human intramuscular nerve and neuromuscular junctions during development .
8512206	0	B-50	18,22	GAP-43	23,29	B-50	GAP-43	2596	2596	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	The expression of B-50 / GAP-43 in Schwann cells .
8613733	0	B-50	53,57	GAP-43	58,64	B-50	GAP-43	14432(Tax:10090)	14432(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Directed expression of the growth-associated protein B-50 / GAP-43 to olfactory neurons in transgenic_mice results in changes in axon morphology and extraglomerular fiber growth .
8243654	0	B-50	15,19	Neurogranin	0,11	B-50	Neurogranin	2596	4900	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	Neurogranin , a B-50 / GAP-43-immunoreactive C-kinase substrate -LRB- BICKS -RRB- , is ADP-ribosylated .
2146368	0	B-50	53,57	calmodulin	28,38	B-50	calmodulin	2596	808	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Evidence for the binding of calmodulin to endogenous B-50 -LRB- GAP-43 -RRB- in native synaptosomal_plasma_membranes .
8954125	0	B-ATF	28,33	AP1	51,54	B-ATF	AP1	10538	3726	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	IFP_35 forms complexes with B-ATF , a member of the AP1 family of transcription factors .
10728810	0	B-CAM	48,53	basal_cell_adhesion_molecule	18,46	B-CAM	basal cell adhesion molecule	4059	4059	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the basal_cell_adhesion_molecule -LRB- B-CAM -RRB- in normal and diseased human skin .
27041273	0	B-Cell_Lymphoma_2	85,102	Bcl-2	104,109	B-Cell Lymphoma 2	Bcl-2	596	596	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Cotton_Leaf_Curl_Multan_Betasatellite DNA as a Tool to Deliver and Express the Human B-Cell_Lymphoma_2 -LRB- Bcl-2 -RRB- Gene in Plants .
2061622	0	B-FGF	32,37	Basic_fibroblast_growth_factor	0,30	B-FGF	Basic fibroblast growth factor	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor -LRB- B-FGF -RRB- induces early - -LRB- CFU-s -RRB- and late-stage hematopoietic progenitor cell colony formation -LRB- CFU-gm , CFU-meg , and BFU-e -RRB- by synergizing with GM-CSF , Meg-CSF , and erythropoietin , and is a radioprotective agent in vitro .
8910512	0	B-MYB	47,52	p107	33,37	B-MYB	p107	4605	5933	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	The retinoblastoma family member p107 binds to B-MYB and suppresses its autoregulatory activity .
21148321	0	B-MYB	0,5	serine-threonine_kinase_receptor-associated_protein	27,78	B-MYB	serine-threonine kinase receptor-associated protein	4605	11171	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	B-MYB positively regulates serine-threonine_kinase_receptor-associated_protein -LRB- STRAP -RRB- activity through direct interaction .
25557911	0	B-Myb	20,25	Cyclin_F	0,8	B-Myb	Cyclin F	4605	899	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	Cyclin_F suppresses B-Myb activity to promote cell cycle checkpoint control .
18624722	0	B-Myb	14,19	E2F1	23,27	B-Myb	E2F1	4605	1869	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of B-Myb by E2F1 in hepatocellular_carcinoma .
10645009	0	B-Myb	14,19	cyclin_D1	32,41	B-Myb	cyclin D1	4605	595	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of B-Myb activity by cyclin_D1 .
15615710	0	B-Myb	0,5	elastin	16,23	B-Myb	elastin	17865(Tax:10090)	13717(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	B-Myb represses elastin gene expression in aortic smooth muscle cells .
12439743	0	B-Myb	0,5	p107	101,105	B-Myb	p107	4605	5933	Gene	Gene	overcomes|nsubj|START_ENTITY overcomes|advcl|interacting interacting|nmod|domain domain|nmod|END_ENTITY	B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107 .
25502082	0	B-Myb	0,5	snail	16,21	B-Myb	snail	4605	6615	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	B-Myb regulates snail expression to promote epithelial-to-mesenchymal transition and invasion of breast_cancer cell .
16266992	0	B-RAF	104,109	C-RAF	52,57	B-RAF	C-RAF	673	5894	Gene	Gene	activity|nmod|START_ENTITY has|dobj|activity has|nsubj|END_ENTITY	Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF .
16364920	0	B-RAF	21,26	C-RAF	36,41	B-RAF	C-RAF	673	5894	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization .
19638574	0	B-RAF	71,76	KRAS	80,84	B-RAF	KRAS	673	3845	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Sorafenib inhibits non-small_cell_lung_cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells .
18045987	0	B-RAF	0,5	Rnd3	20,24	B-RAF	Rnd3	673	390	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization .
18953432	0	B-RAF	45,50	p16INK4a	0,8	B-RAF	p16INK4a	673	1029	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity_in_melanoma_tumors .
18194435	0	B-Raf	34,39	ATF-3	14,19	B-Raf	ATF-3	673	467	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074 .
18490924	0	B-Raf	0,5	ERK	22,25	B-Raf	ERK	109880(Tax:10090)	26413(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic_beta-cell_carcinogenesis .
8954940	0	B-Raf	36,41	ERK3	26,30	B-Raf	ERK3	114486(Tax:10116)	58840(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	A specific association of ERK3 with B-Raf in rat hippocampus .
7835430	0	B-Raf	52,57	MEK-1	68,73	B-Raf	MEK-1	114486(Tax:10116)	170851(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Regulation of the MAP kinase cascade in PC12 cells : B-Raf activates MEK-1 -LRB- MAP kinase or ERK kinase -RRB- and is inhibited by cAMP .
15258589	0	B-Raf	43,48	MLK3	0,4	B-Raf	MLK3	673	4296	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	MLK3 is required for mitogen activation of B-Raf , ERK and cell proliferation .
16537381	0	B-Raf	33,38	Mixed-lineage_kinase_3	0,22	B-Raf	Mixed-lineage kinase 3	673	4296	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Mixed-lineage_kinase_3 regulates B-Raf through maintenance of the B-Raf/Raf -1 complex and inhibition by the NF2 tumor suppressor protein .
18515281	0	B-Raf	16,21	RKTG	0,4	B-Raf	RKTG	673	152559	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant_melanoma cells .
19690147	0	B-Raf	26,31	Sprouty2	0,8	B-Raf	Sprouty2	673	10253	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation .
15467451	0	B-Raf	50,55	mixed_lineage_kinase_3	17,39	B-Raf	mixed lineage kinase 3	673	4296	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	A novel role for mixed_lineage_kinase_3 -LRB- MLK3 -RRB- in B-Raf activation and cell proliferation .
26190239	0	B-Raf_proto-oncogene	32,52	BRAF	54,58	B-Raf proto-oncogene	BRAF	673	673	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Melanocytic nevi excised during B-Raf_proto-oncogene -LRB- BRAF -RRB- inhibitor therapy : A study of 19 lesions from 10 patients .
18155301	0	B-cell-activating_factor	14,38	BLyS	71,75	B-cell-activating factor	BLyS	10673	10673	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|compound|END_ENTITY	Regulation of B-cell-activating_factor -LRB- BAFF -RRB- / B_lymphocyte_stimulator -LRB- BLyS -RRB- expression in human neutrophils .
18155301	0	B-cell-activating_factor	14,38	B_lymphocyte_stimulator	46,69	B-cell-activating factor	B lymphocyte stimulator	10673	10673	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|compound|END_ENTITY	Regulation of B-cell-activating_factor -LRB- BAFF -RRB- / B_lymphocyte_stimulator -LRB- BLyS -RRB- expression in human neutrophils .
21576203	0	B-cell-attracting_chemokine-1	29,58	CXCL13	66,72	B-cell-attracting chemokine-1	CXCL13	10563	10563	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Elevated production of serum B-cell-attracting_chemokine-1 -LRB- BCA-1 / CXCL13 -RRB- is correlated with childhood-onset lupus_disease activity , severity , and renal involvement .
12393412	0	B-cell-attracting_chemokine_1	14,43	CXCL13	45,51	B-cell-attracting chemokine 1	CXCL13	10563	10563	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of B-cell-attracting_chemokine_1 -LRB- CXCL13 -RRB- by malignant lymphocytes and vascular endothelium in primary central_nervous_system_lymphoma .
23878841	0	B-cell_activating_factor	19,43	BAFF	45,49	B-cell activating factor	BAFF	10673	10673	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Salivary and serum B-cell_activating_factor -LRB- BAFF -RRB- levels after hydroxychloroquine treatment in primary Sj gren 's syndrome .
25656062	0	B-cell_activating_factor	16,40	BAFF	42,46	B-cell activating factor	BAFF	10673	10673	Gene	Gene	presence|nmod|START_ENTITY presence|appos|END_ENTITY	The presence of B-cell_activating_factor -LRB- BAFF -RRB- in umbilical cord blood in both healthy and pre-eclamptic pregnancies and in human breast milk .
22187460	0	B-cell_adapter_for_PI3K	9,32	BCAP	34,38	B-cell adapter for PI3K	BCAP	118788	118788	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role for B-cell_adapter_for_PI3K -LRB- BCAP -RRB- as a signaling adapter linking Toll-like receptors -LRB- TLRs -RRB- to serine/threonine kinases PI3K/Akt .
22187460	0	B-cell_adapter_for_PI3K	9,32	PI3K/Akt	126,134	B-cell adapter for PI3K	PI3K/Akt	118788	5293;207	Gene	Gene	Role|nmod|START_ENTITY kinases|nsubj|Role kinases|dobj|END_ENTITY	Role for B-cell_adapter_for_PI3K -LRB- BCAP -RRB- as a signaling adapter linking Toll-like receptors -LRB- TLRs -RRB- to serine/threonine kinases PI3K/Akt .
12411479	0	B-cell_antigen_receptor	71,94	Raf-1	62,67	B-cell antigen receptor	Raf-1	416952(Tax:9031)	396245(Tax:9031)	Gene	Gene	signalling|amod|START_ENTITY END_ENTITY|nmod|signalling	Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell_antigen_receptor signalling .
2887297	0	B-cell_differentiation_factor	47,76	BCDF	78,82	B-cell differentiation factor	BCDF	3569	3569	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional and biochemical characterization of B-cell_differentiation_factor -LRB- BCDF -RRB- produced by an HTLV-I-transformed human T-cell clone and demonstration of specific binding of the factor to a BCDF responsive cell line .
18926796	0	B-cell_integration_cluster	74,100	Latent_membrane_protein-1	0,25	B-cell integration cluster	Latent membrane protein-1	114614	9260	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Latent_membrane_protein-1 of Epstein-Barr_virus induces the expression of B-cell_integration_cluster , a precursor form of microRNA-155 , in B_lymphoma cell lines .
15077128	0	B-cell_leukemia	7,22	BCL1	33,37	B-cell leukemia	BCL1	12443(Tax:10090)	12443(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|appos|END_ENTITY	Murine B-cell_leukemia lymphoma -LRB- BCL1 -RRB- cells as a target for NK cell-mediated immunotherapy .
14654791	0	B-cell_lymphoma_gene	22,42	BCL-6	46,51	B-cell lymphoma gene	BCL-6	12053(Tax:10090)	604	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Protein expression of B-cell_lymphoma_gene 6 -LRB- BCL-6 -RRB- in invasive breast_cancer is associated with cyclin_D1 and hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- .
20339926	0	B-cell_maturation_antigen	72,97	B-lymphocyte-induced_maturation_protein1	0,40	B-cell maturation antigen	B-lymphocyte-induced maturation protein1	21935(Tax:10090)	12142(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	B-lymphocyte-induced_maturation_protein1 up-regulates the expression of B-cell_maturation_antigen in mouse plasma cells .
22166983	0	B-cell_maturation_antigen	0,25	BCMA	27,31	B-cell maturation antigen	BCMA	608	608	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	B-cell_maturation_antigen -LRB- BCMA -RRB- activation exerts specific proinflammatory effects in normal human keratinocytes and is preferentially expressed in inflammatory skin pathologies .
2955412	0	B-cell_stimulatory_factor_1	7,34	Fc_receptor	79,90	B-cell stimulatory factor 1	Fc receptor	16189(Tax:10090)	109615(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Murine B-cell_stimulatory_factor_1 -LRB- interleukin_4 -RRB- increases expression of the Fc_receptor for IgE on mouse B cells .
26396236	0	B-cell_translocation_gene_1	20,47	BTG1	49,53	B-cell translocation gene 1	BTG1	12226(Tax:10090)	12226(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	A novel function of B-cell_translocation_gene_1 -LRB- BTG1 -RRB- in the regulation of hepatic_insulin_sensitivity in mice via c-Jun .
22493435	0	B-cell_translocation_gene_2	0,27	NFE2L2	121,127	B-cell translocation gene 2	NFE2L2	7832	4780	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	B-cell_translocation_gene_2 -LRB- BTG2 -RRB- stimulates cellular antioxidant defenses through the antioxidant transcription factor NFE2L2 in human mammary epithelial cells .
23703573	0	B-cell_translocation_gene_2	0,27	insulin	66,73	B-cell translocation gene 2	insulin	7832	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	B-cell_translocation_gene_2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic b-cells .
16040253	0	B-lymphocyte-induced_maturation_protein-1	0,41	Blimp-1	43,50	B-lymphocyte-induced maturation protein-1	Blimp-1	446070(Tax:31033)	446070(Tax:31033)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	B-lymphocyte-induced_maturation_protein-1 -LRB- Blimp-1 -RRB- gene of torafugu -LRB- Takifugu_rubripes -RRB- .
20339926	0	B-lymphocyte-induced_maturation_protein1	0,40	B-cell_maturation_antigen	72,97	B-lymphocyte-induced maturation protein1	B-cell maturation antigen	12142(Tax:10090)	21935(Tax:10090)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	B-lymphocyte-induced_maturation_protein1 up-regulates the expression of B-cell_maturation_antigen in mouse plasma cells .
12147683	0	B-myb	2,7	p107	93,97	B-myb	p107	17865(Tax:10090)	19650(Tax:10090)	Gene	Gene	site|amod|START_ENTITY facilitates|nsubj|site facilitates|nmod|E2F E2F|amod|END_ENTITY	A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes .
7648369	0	B-raf	1,6	Mek-1	47,52	B-raf	Mek-1	109880(Tax:10090)	26395(Tax:10090)	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|kinase kinase|amod|END_ENTITY	-LSB- B-raf gene encodes for multiple isoforms with Mek-1 kinase activity -RSB- .
12706919	0	B-type_natriuretic_peptide	120,146	B-type_natriuretic_peptide	14,40	B-type natriuretic peptide	B-type natriuretic peptide	4879	4879	Gene	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of B-type_natriuretic_peptide for risk assessment in unstable angina/non-ST-elevation myocardial_infarction : B-type_natriuretic_peptide and prognosis in TACTICS-TIMI 18 .
12706919	0	B-type_natriuretic_peptide	14,40	B-type_natriuretic_peptide	120,146	B-type natriuretic peptide	B-type natriuretic peptide	4879	4879	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|END_ENTITY	Evaluation of B-type_natriuretic_peptide for risk assessment in unstable angina/non-ST-elevation myocardial_infarction : B-type_natriuretic_peptide and prognosis in TACTICS-TIMI 18 .
16098869	0	B-type_natriuretic_peptide	14,40	BNP	42,45	B-type natriuretic peptide	BNP	4879	4879	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Evaluation of B-type_natriuretic_peptide -LRB- BNP -RRB- levels in normal and preeclamptic women .
17044575	0	B-type_natriuretic_peptide	24,50	BNP	52,55	B-type natriuretic peptide	BNP	4879	4879	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of point-of-care B-type_natriuretic_peptide -LRB- BNP -RRB- measurement on medical decision-making for older emergency department patients with dyspnea .
17567649	0	B-type_natriuretic_peptide	21,47	BNP	49,52	B-type natriuretic peptide	BNP	4879	4879	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the B-type_natriuretic_peptide -LRB- BNP -RRB- gene are associated with NT-proBNP levels but not with diabetic_nephropathy or mortality in type 1 diabetic patients .
18340156	0	B-type_natriuretic_peptide	29,55	BNP	57,60	B-type natriuretic peptide	BNP	4879	4879	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Updated algorithms for using B-type_natriuretic_peptide -LRB- BNP -RRB- levels in the diagnosis and management of congestive_heart_failure .
19650993	0	B-type_natriuretic_peptide	1,27	BNP	29,32	B-type natriuretic peptide	BNP	25105(Tax:10116)	25105(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- B-type_natriuretic_peptide -LRB- BNP -RRB- levels and the effects of carvedilol on BNP levels in juvenile rats with right_heart_failure -RSB- .
19833319	0	B-type_natriuretic_peptide	25,51	BNP	53,56	B-type natriuretic peptide	BNP	4879	4879	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	-LSB- Prognostic value of the B-type_natriuretic_peptide -LRB- BNP -RRB- in a cardiogeriatric department -RSB- .
26173591	0	B-type_natriuretic_peptide	10,36	BNP	38,41	B-type natriuretic peptide	BNP	4879	4879	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of B-type_natriuretic_peptide -LRB- BNP -RRB- on development of atrial_fibrillation in people with Type 2 diabetes .
26173591	0	B-type_natriuretic_peptide	10,36	BNP	38,41	B-type natriuretic peptide	BNP	4879	4879	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of B-type_natriuretic_peptide -LRB- BNP -RRB- on development of atrial_fibrillation in people with Type 2 diabetes .
21812548	0	B-type_natriuretic_peptide	69,95	ERK	100,103	B-type natriuretic peptide	ERK	25105(Tax:10116)	24338(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	M-CAT element mediates mechanical stretch-activated transcription of B-type_natriuretic_peptide via ERK activation .
11279028	0	B-type_natriuretic_peptide	56,82	GATA-4	26,32	B-type natriuretic peptide	GATA-4	4879	2626	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Cooperative activation by GATA-4 and YY1 of the cardiac B-type_natriuretic_peptide promoter .
19139378	0	B-type_natriuretic_peptide	28,54	Yin_Yang_1	86,96	B-type natriuretic peptide	Yin Yang 1	4879	7528	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|nmod|END_ENTITY	Endothelin-stimulated human B-type_natriuretic_peptide gene expression is mediated by Yin_Yang_1 in association with histone_deacetylase_2 .
23207119	0	B-type_natriuretic_peptide	59,85	adiponectin	14,25	B-type natriuretic peptide	adiponectin	4879	9370	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Total and HMW adiponectin is independently associated with B-type_natriuretic_peptide and anemia in chronic_hemodialysis patients .
11354260	0	B-type_natriuretic_peptide	14,40	atrial_natriuretic_peptide	44,70	B-type natriuretic peptide	atrial natriuretic peptide	18158(Tax:10090)	230899(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Expression of B-type_natriuretic_peptide in atrial_natriuretic_peptide gene disrupted mice .
19139378	0	B-type_natriuretic_peptide	28,54	histone_deacetylase_2	117,138	B-type natriuretic peptide	histone deacetylase 2	4879	3066	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|nmod|END_ENTITY	Endothelin-stimulated human B-type_natriuretic_peptide gene expression is mediated by Yin_Yang_1 in association with histone_deacetylase_2 .
21541636	0	B104-1	33,39	p185	14,18	B104-1	p185	947391(Tax:511145)	66515(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Regulation of p185 expression in B104-1 cells transfected with antisense neu retrovirus vectors .
23351078	0	B1_and_B2	53,62	IL-1b	23,28	B1 and B2	IL-1b	931	3553	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	IL-4 and IL-13 inhibit IL-1b and TNF-a induced kinin B1_and_B2 receptors through a STAT6-dependent mechanism .
9918799	0	B1_receptor	53,64	Interleukin_8	0,13	B1 receptor	Interleukin 8	623	3576	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- induces the expression of kinin B1_receptor in human lung fibroblasts .
8449036	0	B2-1	20,24	D17S811E	31,39	B2-1	D17S811E	9267	9267	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of human B2-1 gene -LRB- D17S811E -RRB- to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization .
1334347	0	B2-receptor	105,116	Bradykinin	0,10	B2-receptor	Bradykinin	624	3827	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Bradykinin suppresses endothelin-induced contraction of coronary , renal and femoral arteries through its B2-receptor on the endothelium .
1659421	0	B2-receptor	84,95	Bradykinin	0,10	B2-receptor	Bradykinin	624	3827	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Bradykinin suppresses endothelin-induced contraction of coronary artery through its B2-receptor on the endothelium .
10433247	0	B2036	36,41	prolactin_receptor	69,87	B2036	prolactin receptor	945235(Tax:511145)	5618	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The human growth_hormone antagonist B2036 does not interact with the prolactin_receptor .
16797412	0	B220	102,106	CD11b	108,113	B220	CD11b	19264(Tax:10090)	16409(Tax:10090)	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	Interleukin-7 partially rescues B-lymphopoiesis in osteopetrotic oc/oc mice through the engagement of B220 + CD11b + progenitors .
2456858	0	B220	25,29	L3T4	31,35	B220	L3T4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Ontogeny and function of B220 + L3T4 + T-cell subset of MRL/Mp-lpr/lpr mice .
2456858	4	B220	774,778	L3T4	780,784	B220	L3T4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	that|nmod|START_ENTITY that|dep|cells cells|nummod|+ +|compound|END_ENTITY	The expression level of L3T4 antigen on the T subset was lower than that on B220 - L3T4 + cells , while the level of B220 antigen was similar to that of B220 + L3T4 - or B220 + Lyt_2 - cells .
8620867	0	B23	19,22	C23	0,3	C23	C23	4691	4691	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	C23 interacts with B23 , a putative nucleolar-localization-signal-binding protein .
20011973	0	B23	0,3	PES1	19,23	B23	PES1	4869	23481	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	B23 interacts with PES1 and is involved in nucleolar localization of PES1 .
10552962	0	B29	32,35	CD79b	37,42	B29	CD79b	974	974	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of the B-cell receptor B29 -LRB- CD79b -RRB- gene in familial chronic_lymphocytic_leukemia .
7913081	0	B29	50,53	CD79b	35,40	B29	CD79b	974	974	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The complete sequence of the human CD79b -LRB- Ig_beta / B29 -RRB- gene : identification of a conserved exon/intron organization , immunoglobulin-like regulatory regions , and allelic polymorphism .
9269755	0	B29	35,38	CD79b	40,45	B29	CD79b	974	974	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Aberrations of the B-cell receptor B29 -LRB- CD79b -RRB- gene in chronic_lymphocytic_leukemia .
15040449	0	B29	37,40	Ig_beta	42,49	B29	Ig beta	974	974	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A conserved sequence upstream of the B29 -LRB- Ig_beta , CD79b -RRB- gene interacts with YY1 .
9858563	0	B29	4,7	early_B-cell_factor	65,84	B29	early B-cell factor	15985(Tax:10090)	13591(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	The B29 -LRB- immunoglobulin beta-chain -RRB- gene is a genetic target for early_B-cell_factor .
26406402	0	B2M	18,21	ALK7	34,38	B2M	ALK7	567	130399	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Overexpression of B2M and loss of ALK7 expression are associated with invasion , metastasis , and poor-prognosis of the pancreatic_ductal_adenocarcinoma .
8127790	0	B2MG	33,37	beta-2-microglobulin	11,31	B2MG	beta-2-microglobulin	567	567	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	-LSB- Levels of beta-2-microglobulin -LRB- B2MG -RRB- in blood serum of patients during the early phase after kidney transplantation -RSB- .
16337452	0	B2_receptor	86,97	Bradykinin	0,10	B2 receptor	Bradykinin	624	3827	Gene	Gene	phenotype|nmod|START_ENTITY differentiates|nmod|phenotype differentiates|nsubj|END_ENTITY	Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2_receptor .
24833299	0	B2_receptor	47,58	Bradykinin	0,10	B2 receptor	Bradykinin	624	3827	Gene	Gene	activation|amod|START_ENTITY production|nmod|activation induces|dobj|production induces|nsubj|END_ENTITY	Bradykinin induces NO and PGF2a production via B2_receptor activation from cultured porcine basilar arterial endothelial cells .
9657256	0	B2_receptor	100,111	Bradykinin	0,10	B2 receptor	Bradykinin	624	3827	Gene	Gene	subtype|amod|START_ENTITY line|nmod|subtype increases|nmod|line increases|nsubj|END_ENTITY	Bradykinin increases intracellular calcium levels in a human bronchial epithelial cell line via the B2_receptor subtype .
9614202	0	B2_receptor	37,48	Interleukin-1beta	0,17	B2 receptor	Interleukin-1beta	624	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces bradykinin B2_receptor gene expression through a prostanoid cyclic_AMP-dependent pathway in human bronchial smooth muscle cells .
10082496	0	B2_receptor	53,64	bradykinin	15,25	B2 receptor	bradykinin	624	3827	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of bradykinin and resensitization of its B2_receptor .
10551272	0	B2_receptor	69,80	bradykinin	58,68	B2 receptor	bradykinin	624	3827	Gene	Gene	FR_190997|compound|START_ENTITY FR_190997|compound|END_ENTITY	Pharmacological characterisation of the first non-peptide bradykinin B2_receptor agonist FR_190997 : an in vitro study on human , rabbit and pig vascular B2_receptors .
11311137	0	B2_receptor	115,126	bradykinin	38,48	B2 receptor	bradykinin	624	3827	Gene	Gene	sequestration|nmod|START_ENTITY trafficking|dep|sequestration trafficking|nmod|receptors receptors|compound|END_ENTITY	Agonist-promoted trafficking of human bradykinin receptors : arrestin - and dynamin-independent sequestration of the B2_receptor and bradykinin in HEK293 cells .
11517947	0	B2_receptor	32,43	bradykinin	21,31	B2 receptor	bradykinin	624	3827	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the bradykinin B2_receptor gene and childhood asthma .
12574004	0	B2_receptor	43,54	bradykinin	139,149	B2 receptor	bradykinin	624	3827	Gene	Gene	portion|nmod|START_ENTITY Changes|nmod|portion increase|nsubj|Changes increase|dep|not not|nmod|END_ENTITY	Changes in amino-terminal portion of human B2_receptor selectively increase efficacy of synthetic ligand HOE_140 but not of cognate ligand bradykinin .
12705334	0	B2_receptor	74,85	bradykinin	63,73	B2 receptor	bradykinin	624	3827	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Rapid and reliable genotyping of the C181T polymorphism in the bradykinin B2_receptor gene .
20050188	0	B2_receptor	88,99	bradykinin	26,36	B2 receptor	bradykinin	624	3827	Gene	Gene	antagonism|amod|START_ENTITY characterization|nmod|antagonism characterization|compound|END_ENTITY	Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2_receptor antagonism in human synovial fibroblasts .
20050188	0	B2_receptor	88,99	bradykinin	77,87	B2 receptor	bradykinin	624	3827	Gene	Gene	antagonism|amod|START_ENTITY antagonism|amod|END_ENTITY	Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2_receptor antagonism in human synovial fibroblasts .
22970904	0	B2_receptor	27,38	bradykinin	16,26	B2 receptor	bradykinin	624	3827	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Icatibant , the bradykinin B2_receptor antagonist with target to the interconnected kinin systems .
2907489	0	B2_receptor	36,47	bradykinin	22,32	B2 receptor	bradykinin	624	3827	Gene	Gene	agonist|amod|START_ENTITY END_ENTITY|appos|agonist	-LSB- Phe8 psi -LRB- CH2-NH -RRB- Arg9 -RSB- bradykinin , a B2_receptor selective agonist which is not broken down by either kininase_I or kininase_II .
8856140	0	B2_receptor	4,15	bradykinin	80,90	B2 receptor	bradykinin	624	3827	Gene	Gene	START_ENTITY|dep|release release|nmod|arachidonic_acid arachidonic_acid|nmod|END_ENTITY	The B2_receptor on cultured human decidua cells : release of arachidonic_acid by bradykinin .
8873604	0	B2_receptor	35,46	bradykinin	24,34	B2 receptor	bradykinin	624	3827	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Na + ions binding to the bradykinin B2_receptor suppress agonist-independent receptor activation .
8910316	0	B2_receptor	111,122	bradykinin	36,46	B2 receptor	bradykinin	624	3827	Gene	Gene	amino_acids|nmod|START_ENTITY bound|dobj|amino_acids bound|nsubjpass|group group|nmod|END_ENTITY	The N-terminal amino group of -LSB- Tyr8 -RSB- bradykinin is bound adjacent to analogous amino_acids of the human and rat B2_receptor .
8939910	0	B2_receptor	64,75	bradykinin	18,28	B2 receptor	bradykinin	624	3827	Gene	Gene	adjacent|nsubj|START_ENTITY terminus|advcl|adjacent terminus|nmod|END_ENTITY	The N terminus of bradykinin when bound to the human bradykinin B2_receptor is adjacent to extracellular Cys20 and Cys277 in the receptor .
8939910	0	B2_receptor	64,75	bradykinin	53,63	B2 receptor	bradykinin	624	3827	Gene	Gene	START_ENTITY|amod|bound bound|nmod|END_ENTITY	The N terminus of bradykinin when bound to the human bradykinin B2_receptor is adjacent to extracellular Cys20 and Cys277 in the receptor .
9119014	0	B2_receptor	100,111	bradykinin	48,58	B2 receptor	bradykinin	624	3827	Gene	Gene	mimic|nmod|START_ENTITY mimic|nsubj|study study|nmod|interaction interaction|nmod|END_ENTITY	An NMR study of the interaction of 15N-labelled bradykinin with an antibody mimic of the bradykinin B2_receptor .
9224807	0	B2_receptor	77,88	bradykinin	20,30	B2 receptor	bradykinin	624	3827	Gene	Gene	properties|nmod|START_ENTITY mimic|nmod|properties mimic|nmod|END_ENTITY	Nonpeptide mimic of bradykinin with long-acting properties at the bradykinin B2_receptor .
9600070	0	B2_receptor	66,77	bradykinin	55,65	B2 receptor	bradykinin	624	3827	Gene	Gene	association|compound|START_ENTITY association|compound|END_ENTITY	Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2_receptor association of phospholipase_C_gamma_1 in vascular endothelial cells .
9606729	0	B2_receptor	92,103	bradykinin	53,63	B2 receptor	bradykinin	624	3827	Gene	Gene	mimic|nmod|START_ENTITY mimic|nsubj|investigations investigations|nmod|END_ENTITY	NMR investigations of recombinant 15N/13C/2H-labeled bradykinin bound to a Fab mimic of the B2_receptor .
9614202	0	B2_receptor	37,48	bradykinin	26,36	B2 receptor	bradykinin	624	3827	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Interleukin-1beta induces bradykinin B2_receptor gene expression through a prostanoid cyclic_AMP-dependent pathway in human bronchial smooth muscle cells .
9727019	0	B2_receptor	42,53	endothelial_nitric-oxide_synthase	59,92	B2 receptor	endothelial nitric-oxide synthase	624	4846	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Inhibitory interactions of the bradykinin B2_receptor with endothelial_nitric-oxide_synthase .
15211654	0	B4GALT7	58,65	galactosyltransferase-I	33,56	B4GALT7	galactosyltransferase-I	11285	11285	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel missense mutation in the galactosyltransferase-I -LRB- B4GALT7 -RRB- gene in a family exhibiting facioskeletal_anomalies and Ehlers-Danlos_syndrome resembling the progeroid type .
21436382	0	B55	23,26	nitrate_reductase	67,84	B55	nitrate reductase	842360(Tax:3702)	844112(Tax:3702)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Protein phosphatase_2A B55 and A regulatory subunits interact with nitrate_reductase and are essential for nitrate_reductase activation .
25792973	0	B55gamma	112,120	Salt-inducible_kinase_2	24,47	B55gamma	Salt-inducible kinase 2	5522	23235	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association between Salt-inducible_kinase_2 -LRB- SIK2 -RRB- and gamma isoform of the regulatory subunit B55 of PP2A -LRB- B55gamma -RRB- contributes to the survival of glioma cells under glucose depletion through inhibiting the phosphorylation of S6K .
20378546	0	B56alpha	78,86	B56alpha	96,104	B56alpha	B56alpha	5525	5525	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha : role of B56alpha in nuclear export of the catalytic subunit .
20378546	0	B56alpha	96,104	B56alpha	78,86	B56alpha	B56alpha	5525	5525	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha : role of B56alpha in nuclear export of the catalytic subunit .
10866685	0	B56alpha	4,12	phosphatase_2A	43,57	B56alpha	phosphatase 2A	5525	5524	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The B56alpha regulatory subunit of protein phosphatase_2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR .
17297438	0	B56beta	58,65	PP2A	77,81	B56beta	PP2A	5526	5524	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A .
7780963	0	B61	50,53	B61	8,11	B61	B61	1942	1942	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Protein B61 as a new growth factor : expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression .
7780963	0	B61	8,11	B61	50,53	B61	B61	1942	1942	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Protein B61 as a new growth factor : expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression .
10934151	1	B7-1	110,114	B7-2	130,134	B7-1	B7-2	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	/|dep|START_ENTITY END_ENTITY|amod|/	Studies using mice lacking B7-1 , B7-2 , or B7-1 / B7-2 .
12759417	0	B7-1	15,19	B7-2	20,24	B7-1	B7-2	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for the B7-1 / B7-2 : CD28/CTLA -4 pathway during negative selection .
23744647	0	B7-1	0,4	B7-2	5,9	B7-1	B7-2	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	START_ENTITY|appos|overrides overrides|nsubj|blockade blockade|compound|END_ENTITY	B7-1 / B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3 + regulatory T cells .
8557978	0	B7-1	75,79	B7-2	91,95	B7-1	B7-2	941	942	Gene	Gene	CD80|appos|START_ENTITY CD80|appos|END_ENTITY	Differential effects of CTLA-4 substitutions on the binding of human CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- .
8557988	0	B7-1	0,4	B7-2	20,24	B7-1	B7-2	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|costimulation costimulation|compound|END_ENTITY	B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity .
8566020	0	B7-1	205,209	B7-2	221,225	B7-1	B7-2	941	942	Gene	Gene	CD80|appos|START_ENTITY CD80|appos|END_ENTITY	Malignant B lymphocytes from non-Hodgkin 's _ lymphoma induce allogeneic proliferative and cytotoxic T cell responses in primary mixed lymphocyte cultures : an important role of co-stimulatory molecules CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- in stimulation by tumor cells .
8642061	0	B7-1	44,48	B7-2	66,70	B7-1	B7-2	941	942	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Opposing effects of CTLA4-Ig and anti-CD80 -LRB- B7-1 -RRB- plus anti-CD86 -LRB- B7-2 -RRB- on experimental_allergic_encephalomyelitis .
8814278	0	B7-1	6,10	B7-2	34,38	B7-1	B7-2	941	942	Gene	Gene	efficient|nsubj|START_ENTITY efficient|nmod|END_ENTITY	Human B7-1 is more efficient than B7-2 in providing co-stimulation for alloantigen-specific T cells .
9014827	0	B7-1	46,50	B7-2	62,66	B7-1	B7-2	941	942	Gene	Gene	CD80|appos|START_ENTITY CD80|appos|END_ENTITY	Differential expression and function of CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- on human peripheral blood monocytes .
9600317	0	B7-1	22,26	B7-2	12,16	B7-1	B7-2	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	Blockade|amod|START_ENTITY Blockade|nmod|END_ENTITY	Blockade of B7-2 , not B7-1 , inhibits purified protein derivative-primed T-lymphocyte responses but fails to influence the proportion of Th1 versus Th2 subsets .
9628461	0	B7-1	20,24	B7-2	36,40	B7-1	B7-2	941	942	Gene	Gene	CD80|appos|START_ENTITY END_ENTITY|nsubj|CD80	Costimulatory CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- on cerebrospinal fluid cells in multiple_sclerosis .
10233753	0	B7-1	15,19	CD80	21,25	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Enhancement of B7-1 -LRB- CD80 -RRB- expression on B-lymphoma cells by irradiation .
10393529	0	B7-1	56,60	CD80	50,54	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel stimulus , oncogene , induces expression of CD80 -LRB- B7-1 -RRB- gene .
10528182	0	B7-1	26,30	CD80	32,36	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Mutual regulation between B7-1 -LRB- CD80 -RRB- expressed on T cells and IL-4 .
11342441	0	B7-1	15,19	CD80	21,25	B7-1	CD80	941	941	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Targeting of a B7-1 -LRB- CD80 -RRB- immunoglobulin G fusion protein to acute_myeloid_leukemia blasts increases their costimulatory activity for autologous remission T cells .
11459169	0	B7-1	6,10	CD80	0,4	B7-1	CD80	941	941	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CD80 -LRB- B7-1 -RRB- expression on human acute myeloid leukaemic cells cultured with GM-CSF , _ IL-3 and IL-6 .
11698282	0	B7-1	127,131	CD80	121,125	B7-1	CD80	941	941	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 -LRB- B7-1 -RRB- expression after huCD40LT stimulation because of inhibition by transforming_growth_factor-beta1 and interleukin-10 .
11956426	0	B7-1	19,23	CD80	25,29	B7-1	CD80	941	941	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phase I trial of a B7-1 -LRB- CD80 -RRB- gene modified autologous_tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic_renal_cell_carcinoma .
12100477	0	B7-1	71,75	CD80	65,69	B7-1	CD80	941	941	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Expansion of CD5 - B cells in multiple_sclerosis correlates with CD80 -LRB- B7-1 -RRB- expression .
12860928	0	B7-1	36,40	CD80	41,45	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	BCL6 controls the expression of the B7-1 / CD80 costimulatory receptor in germinal center B cells .
16489051	0	B7-1	26,30	CD80	32,36	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Low surface expression of B7-1 -LRB- CD80 -RRB- is an immunoescape mechanism of colon_carcinoma .
8552995	0	B7-1	44,48	CD80	50,54	B7-1	CD80	941	941	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Lipopolysaccharide effectively up-regulates B7-1 -LRB- CD80 -RRB- expression and costimulatory function of human monocytes .
8603815	0	B7-1	48,52	CD80	54,58	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Vaccination of tumor cells transfected with the B7-1 -LRB- CD80 -RRB- gene induces the anti-metastatic effect and tumor immunity in mice .
9144510	0	B7-1	85,89	CD80	79,83	B7-1	CD80	941	12519(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 -LRB- B7-1 -RRB- but not CD86 -LRB- B7-2 -RRB- on murine fibroblasts .
9233610	0	B7-1	32,36	CD80	38,42	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of donor and recipient B7-1 -LRB- CD80 -RRB- in allograft rejection .
9533442	0	B7-1	73,77	CD80	67,71	B7-1	CD80	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Regulation of T cell autoreactivity to MHC class II by controlling CD80 -LRB- B7-1 -RRB- expression on B cells .
8590734	5	B7-1	727,731	CMS5	733,737	B7-1	CMS5	941	8292	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	We found that neither B7-1 + nor IL-2-secreting , _ B7-1 + CMS5 cells stimulated naive spleen cells to proliferate or to become cytotoxic .
11279502	0	B7-1	25,29	CTLA-4	30,36	B7-1	CTLA-4	941	1493	Gene	Gene	structure|nmod|START_ENTITY Crystal|dobj|structure complex|dep|Crystal complex|compound|END_ENTITY	Crystal structure of the B7-1 / CTLA-4 complex that inhibits human immune responses .
11877291	0	B7-1	69,73	CTLA-4	19,25	B7-1	CTLA-4	12519(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|compound|START_ENTITY vivo|nmod|+ immunity|nmod|vivo induction|nmod|immunity END_ENTITY|nmod|induction	Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1 + , but not B7-2 + , murine myelogenous_leukemia .
8557978	0	B7-1	75,79	CTLA-4	24,30	B7-1	CTLA-4	941	1493	Gene	Gene	CD80|appos|START_ENTITY the|nmod|CD80 substitutions|nmod|the substitutions|nsubj|effects effects|nmod|END_ENTITY	Differential effects of CTLA-4 substitutions on the binding of human CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- .
9815249	0	B7-1	146,150	CTLA-4	151,157	B7-1	CTLA-4	12519(Tax:10090)	12477(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Unresponsive CD4 + T lymphocytes from Leishmania chagasi-infected mice increase cytokine production and mediate parasite killing after blockade of B7-1 / CTLA-4 molecular pathway .
7589143	0	B7-1	40,44	Interleukin-10	0,14	B7-1	Interleukin-10	941	3586	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Interleukin-10 differentially regulates B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- expression on human peripheral blood dendritic cells .
16469054	0	B7-1	38,42	TLR2	0,4	B7-1	TLR2	12519(Tax:10090)	24088(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	TLR2 and TLR4 differentially regulate B7-1 resulting in distinct cytokine responses to the mycoplasma superantigen MAM as well as to disease induced by Mycoplasma_arthritidis .
11360653	0	B7-1	79,83	interferon-gamma	37,53	B7-1	interferon-gamma	941	3458	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	-LSB- Phorbol-12-myristate-13-acetate and interferon-gamma synergistic induction of B7-1 expression in ovary_carcinoma cells and immunological value -RSB- .
20628373	0	B7-1	15,19	interleukin-10	54,68	B7-1	interleukin-10	941	3586	Gene	Gene	molecule|nsubj|START_ENTITY molecule|nmod|production production|amod|END_ENTITY	Stromal cells ' B7-1 is a key stimulatory molecule for interleukin-10 production by HOZOT , a multifunctional regulatory T-cell line .
10934151	1	B7-2	130,134	B7-1	110,114	B7-2	B7-1	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	START_ENTITY|amod|/ /|dep|END_ENTITY	Studies using mice lacking B7-1 , B7-2 , or B7-1 / B7-2 .
12759417	0	B7-2	20,24	B7-1	15,19	B7-2	B7-1	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for the B7-1 / B7-2 : CD28/CTLA -4 pathway during negative selection .
23744647	0	B7-2	5,9	B7-1	0,4	B7-2	B7-1	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY overrides|nsubj|blockade END_ENTITY|appos|overrides	B7-1 / B7-2 blockade overrides the activation of protective CD8 T cells stimulated in the absence of Foxp3 + regulatory T cells .
8557978	0	B7-2	91,95	B7-1	75,79	B7-2	B7-1	942	941	Gene	Gene	CD80|appos|START_ENTITY CD80|appos|END_ENTITY	Differential effects of CTLA-4 substitutions on the binding of human CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- .
8557988	0	B7-2	20,24	B7-1	0,4	B7-2	B7-1	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	costimulation|compound|START_ENTITY superior|nmod|costimulation superior|nsubj|END_ENTITY	B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity .
8566020	0	B7-2	221,225	B7-1	205,209	B7-2	B7-1	942	941	Gene	Gene	CD80|appos|START_ENTITY CD80|appos|END_ENTITY	Malignant B lymphocytes from non-Hodgkin 's _ lymphoma induce allogeneic proliferative and cytotoxic T cell responses in primary mixed lymphocyte cultures : an important role of co-stimulatory molecules CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- in stimulation by tumor cells .
8642061	0	B7-2	66,70	B7-1	44,48	B7-2	B7-1	942	941	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Opposing effects of CTLA4-Ig and anti-CD80 -LRB- B7-1 -RRB- plus anti-CD86 -LRB- B7-2 -RRB- on experimental_allergic_encephalomyelitis .
8814278	0	B7-2	34,38	B7-1	6,10	B7-2	B7-1	942	941	Gene	Gene	efficient|nmod|START_ENTITY efficient|nsubj|END_ENTITY	Human B7-1 is more efficient than B7-2 in providing co-stimulation for alloantigen-specific T cells .
9014827	0	B7-2	62,66	B7-1	46,50	B7-2	B7-1	942	941	Gene	Gene	CD80|appos|START_ENTITY CD80|appos|END_ENTITY	Differential expression and function of CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- on human peripheral blood monocytes .
9600317	0	B7-2	12,16	B7-1	22,26	B7-2	B7-1	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	Blockade|nmod|START_ENTITY Blockade|amod|END_ENTITY	Blockade of B7-2 , not B7-1 , inhibits purified protein derivative-primed T-lymphocyte responses but fails to influence the proportion of Th1 versus Th2 subsets .
9628461	0	B7-2	36,40	B7-1	20,24	B7-2	B7-1	942	941	Gene	Gene	START_ENTITY|nsubj|CD80 CD80|appos|END_ENTITY	Costimulatory CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- on cerebrospinal fluid cells in multiple_sclerosis .
9846836	0	B7-2	13,17	CD80	6,10	B7-2	CD80	942	941	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	B7-1 -LRB- CD80 -RRB- , B7-2 -LRB- CD86 -RRB- , interleukin-12 and transforming_growth_factor-beta mRNA expression in CSF and peripheral blood mononuclear cells from multiple_sclerosis patients .
10521545	0	B7-2	22,26	CD86	16,20	B7-2	CD86	942	942	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- expression in multiple_sclerosis patients : clinical subtype specific variation in peripheral monocytes and B cells and lack of modulation by high dose methylprednisolone .
15989635	0	B7-2	12,16	CD86	18,22	B7-2	CD86	942	942	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of B7-2 -LRB- CD86 -RRB- in tumour immunity .
9199963	0	B7-2	24,28	CD86	30,34	B7-2	CD86	942	942	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The IgV domain of human B7-2 -LRB- CD86 -RRB- is sufficient to co-stimulate T lymphocytes and induce cytokine secretion .
8557978	0	B7-2	91,95	CTLA-4	24,30	B7-2	CTLA-4	942	1493	Gene	Gene	CD80|appos|START_ENTITY the|nmod|CD80 substitutions|nmod|the substitutions|nsubj|effects effects|nmod|END_ENTITY	Differential effects of CTLA-4 substitutions on the binding of human CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- .
10477704	0	B7-2	9,13	interferon-gamma	33,49	B7-2	interferon-gamma	942	3458	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Enhanced B7-2 gene expression by interferon-gamma in human monocytic cells is controlled through transcriptional and posttranscriptional mechanisms .
19948206	0	B7-H1	40,45	CD34	29,33	B7-H1	CD34	29126	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A subpopulation of malignant CD34 + CD138 + B7-H1 + plasma cells is present in multiple_myeloma patients .
16085391	0	B7-H1	38,43	IFN-gamma	0,9	B7-H1	IFN-gamma	29126	3458	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells .
16797416	0	B7-H1	29,34	PD-L1	36,41	B7-H1	PD-L1	29126	29126	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of leukemia-derived B7-H1 -LRB- PD-L1 -RRB- in tumor-T-cell interactions in humans .
17186290	0	B7-H1	18,23	PD-L1	25,30	B7-H1	PD-L1	29126	29126	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of B7-H1 -LRB- PD-L1 -RRB- significantly associates with tumor grade and postoperative prognosis in human urothelial_cancers .
17340590	0	B7-H1	7,12	PD-L1	0,5	B7-H1	PD-L1	29126	29126	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	PD-L1 -LRB- B7-H1 -RRB- expression by urothelial_carcinoma of the bladder and BCG-induced granulomata : associations with localized stage progression .
23656736	0	B7-H1	6,11	PD-L1	0,5	B7-H1	PD-L1	60533(Tax:10090)	574058(Tax:9823)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	PD-L1 / B7-H1 regulates the survival but not the function of CD8 + T cells in herpes_simplex_virus_type_1 latently infected trigeminal ganglia .
24696476	0	B7-H1	33,38	PD-L1	26,31	B7-H1	PD-L1	60533(Tax:10090)	60533(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	HIV-1 Tat protein induces PD-L1 _ -LRB- B7-H1 -RRB- expression on dendritic cells through tumor_necrosis_factor_alpha - and toll-like_receptor_4-mediated mechanisms .
26527522	0	B7-H1	7,12	PD-L1	0,5	B7-H1	PD-L1	29126	29126	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	PD-L1 -LRB- B7-H1 -RRB- expression and the immune tumor microenvironment in primary and metastatic breast_carcinomas .
21830424	0	B7-H1	0,5	interleukin-10	95,109	B7-H1	interleukin-10	29126	3586	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|levels levels|amod|END_ENTITY	B7-H1 up-regulated expression in human hepatocellular_carcinoma tissue : correlation with tumor interleukin-10 levels .
23430453	0	B7-H1	43,48	miR-570	2,9	B7-H1	miR-570	29126	693155	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|amod|END_ENTITY	A miR-570 binding site polymorphism in the B7-H1 gene is associated with the risk of gastric_adenocarcinoma .
25053455	0	B7-H1_and_B7-H4	0,15	FOXP3	75,80	B7-H1 and B7-H4	FOXP3	29126;79679	50943	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	B7-H1_and_B7-H4 expression in colorectal_carcinoma : correlation with tumor FOXP3 -LRB- + -RRB- regulatory T-cell infiltration .
19776675	0	B7-H2	61,66	inducible_costimulator	31,53	B7-H2	inducible costimulator	23308	29851	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression and function of the inducible_costimulator ligand B7-H2 in human airway_smooth_muscle cells .
24630518	0	B7-H3	18,23	CD133	27,32	B7-H3	CD133	80381	8842	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Overexpression of B7-H3 in CD133 + colorectal_cancer cells is associated with cancer progression and survival in human patients .
23128494	0	B7-H3	0,5	IL-10	78,83	B7-H3	IL-10	80381	3586	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	B7-H3 expression in ductal and lobular breast_cancer and its association with IL-10 .
26631755	0	B7-H3	25,30	MMP-2	19,24	B7-H3	MMP-2	80381	4313	Gene	Gene	interaction|dep|START_ENTITY interaction|nmod|END_ENTITY	The interaction of MMP-2 / B7-H3 in human osteoporosis .
25378933	0	B7-H3	0,5	VEGF	54,58	B7-H3	VEGF	80381	7422	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	B7-H3 expression in breast_cancer and upregulation of VEGF through gene silence .
24347572	0	B7-H4	28,33	VTCN1	21,26	B7-H4	VTCN1	79679	79679	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic variation in VTCN1 -LRB- B7-H4 -RRB- is associated with course of disease in juvenile_idiopathic_arthritis .
24765159	0	B7-H4	0,5	interleukin-2	33,46	B7-H4	interleukin-2	79679	3558	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	B7-H4 expression and its role in interleukin-2 / interferon treatment of clear_cell_renal_cell_carcinoma .
19528259	0	B7-H6	21,26	NKp30	98,103	B7-H6	NKp30	374383	259197	Gene	Gene	cell|nsubj|START_ENTITY cell|acl|ligand ligand|nmod|END_ENTITY	The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans .
21422170	0	B7-H6	101,106	NKp30	64,69	B7-H6	NKp30	374383	259197	Gene	Gene	ligand|xcomp|START_ENTITY ligand|nsubj|Structure Structure|nmod|END_ENTITY	Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6 .
21877119	0	B7-H6	0,5	NKp30	6,11	B7-H6	NKp30	374383	259197	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	B7-H6 / NKp30 interaction : a mechanism of alerting NK cells against tumors .
24780758	0	B7-H6	48,53	NKp30	113,118	B7-H6	NKp30	374383	259197	Gene	Gene	shedding|nmod|START_ENTITY cell|acl|shedding cell-activating|nsubj|cell cell-activating|dobj|END_ENTITY	Metalloprotease-mediated tumor cell shedding of B7-H6 , the ligand of the natural killer cell-activating receptor NKp30 .
26057798	0	B7-H6	80,85	NKp30	145,150	B7-H6	NKp30	374383	259197	Gene	Gene	complex|nmod|START_ENTITY analysis|nmod|complex ligand|nsubj|analysis ligand|nmod|END_ENTITY	Expression , crystallization and X-ray diffraction analysis of a complex between B7-H6 , a tumor cell ligand for the natural cytotoxicity receptor NKp30 , and an inhibitory antibody .
12853164	0	B7-related_protein-1	43,63	inducible_co-stimulator	12,35	B7-related protein-1	inducible co-stimulator	50723(Tax:10090)	54167(Tax:10090)	Gene	Gene	interaction|nsubj|START_ENTITY role|parataxis|interaction role|nmod|END_ENTITY	The role of inducible_co-stimulator -LRB- ICOS -RRB- / B7-related_protein-1 -LRB- B7RP-1 -RRB- interaction in the functional development of Peyer 's patches .
1847724	0	B7/BB1	16,22	CD28	4,8	B7/BB1	CD28	941	940	Gene	Gene	provides|nsubj|START_ENTITY ligand|ccomp|provides ligand|nsubj|END_ENTITY	The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4 + T cells .
7678229	0	B7/BB1	0,6	CD28	23,27	B7/BB1	CD28	941	940	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	B7/BB1 , the ligand for CD28 , is expressed on repeatedly activated human T cells in vitro .
7507002	0	B7/BB1	35,41	IL-7	0,4	B7/BB1	IL-7	941	3574	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-7 induces surface expression of B7/BB1 on pre-B cells and an associated increase in their costimulatory effects on T cell proliferation .
22614805	0	B7H1	50,54	TGF-b	0,5	B7H1	TGF-b	29126	7040	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TGF-b of lung_cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation .
11007762	0	B7RP-1	52,58	ICOS	103,107	B7RP-1	CD28	50723(Tax:10090)	940	Gene	Gene	protein|dep|START_ENTITY Characterization|nmod|protein END_ENTITY|nsubj|Characterization	Characterization of a new human B7-related protein : B7RP-1 is the ligand to the co-stimulatory protein ICOS .
12853164	0	B7RP-1	65,71	ICOS	37,41	B7RP-1	ICOS	50723(Tax:10090)	54167(Tax:10090)	Gene	Gene	B7-related_protein-1|appos|START_ENTITY interaction|nsubj|B7-related_protein-1 role|parataxis|interaction role|nmod|inducible_co-stimulator inducible_co-stimulator|appos|END_ENTITY	The role of inducible_co-stimulator -LRB- ICOS -RRB- / B7-related_protein-1 -LRB- B7RP-1 -RRB- interaction in the functional development of Peyer 's patches .
15361696	0	B7RP-1	12,18	ICOS	19,23	B7RP-1	ICOS	50723(Tax:10090)	54167(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of the B7RP-1 / ICOS pathway in renal tubular epithelial antigen presentation to CD4 + Th1 and Th2 cells .
20136724	0	B7RP-1	16,22	ICOS	23,27	B7RP-1	ICOS	50723(Tax:10090)	54167(Tax:10090)	Gene	Gene	/|compound|START_ENTITY Contribution|nmod|/ END_ENTITY|nsubj|Contribution	Contribution of B7RP-1 / ICOS co-stimulation to lethal acute GVHD .
12039981	0	B7RP-1	66,72	inducible_costimulator	74,96	B7RP-1	inducible costimulator	23308	29851	Gene	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Renal tubular epithelial expression of the costimulatory molecule B7RP-1 -LRB- inducible_costimulator ligand -RRB- .
10760791	0	B7h	76,79	ICOS	49,53	B7h	ICOS	50723(Tax:10090)	54167(Tax:10090)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS_ligand .
10549624	0	B7h	0,3	TNFalpha	67,75	B7h	TNFalpha	50723(Tax:10090)	21926(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	B7h , a novel costimulatory homolog of B7 .1 _ and_B7 .2 , is induced by TNFalpha .
22977523	0	BAAT1	47,52	DNA-PK_catalytic_subunit	62,86	BAAT1	DNA-PK catalytic subunit	221927	5591	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK_catalytic_subunit .
17553417	0	BACE	38,42	Caspase-3	0,9	BACE	Caspase-3	23621	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Caspase-3 cleavage of GGA3 stabilizes BACE : implications for Alzheimer 's _ disease .
11211053	0	BACE	42,46	beta-secretase	26,40	BACE	beta-secretase	23621	23621	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Amyloid precursor protein beta-secretase -LRB- BACE -RRB- mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors .
15466887	0	BACE	17,21	beta-secretase	23,37	BACE	beta-secretase	23621	23621	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|dep|END_ENTITY	Demonstration of BACE -LRB- beta-secretase -RRB- phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy .
16293430	0	BACE	53,57	beta-secretase	37,51	BACE	beta-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Linear interaction energy models for beta-secretase -LRB- BACE -RRB- inhibitors : Role of van der Waals , electrostatic , and continuum-solvation terms .
17112725	0	BACE-1	16,22	Beta-secretase	0,14	BACE-1	Beta-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Beta-secretase -LRB- BACE-1 -RRB- inhibitors : accounting for 10s loop flexibility using rigid active sites .
12356481	0	BACE-1	77,83	beta-secretase	61,75	BACE-1	beta-secretase	23621	23621	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Recombinant insect cell expression and purification of human beta-secretase -LRB- BACE-1 -RRB- for X-ray crystallography .
17541560	0	BACE-1	90,96	beta-secretase	74,88	BACE-1	beta-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Multiwell fluorometric and colorimetric microassays for the evaluation of beta-secretase -LRB- BACE-1 -RRB- inhibitors .
23627710	0	BACE1	20,25	BRI2	0,4	BACE1	BRI2	23621	9445	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	BRI2 Interacts with BACE1 and Reduces its Cellular Levels by Reducing the Levels of BACE1 mRNA and Inducing its Degradation Through the Lysosomal Pathway .
23701002	0	BACE1	20,25	BRI2	0,4	BACE1	BRI2	23621	9445	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels .
25957769	0	BACE1	32,37	Clec4g	0,6	BACE1	Clec4g	23821(Tax:10090)	75863(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Clec4g -LRB- LSECtin -RRB- interacts with BACE1 and suppresses Ab generation .
26464978	0	BACE1	47,52	LRP1	0,4	BACE1	LRP1	23621	4035	Gene	Gene	Downregulates|dobj|START_ENTITY Downregulates|nsubj|END_ENTITY	LRP1 Downregulates the Alzheimer 's b-Secretase BACE1 by Modulating Its Intraneuronal Trafficking -LRB- 1,2,3 -RRB- .
17098871	0	BACE1	59,64	LRRTM3	0,6	BACE1	LRRTM3	23621	347731	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer 's _ disease .
16965550	0	BACE1	43,48	RTN3	11,15	BACE1	RTN3	23621	10313	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein .
24874077	0	BACE1	18,23	SIRT1	79,84	BACE1	SIRT1	23621	23411	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	Leptin attenuates BACE1 expression and amyloid-b genesis via the activation of SIRT1 signaling pathway .
23968646	0	BACE1	48,53	STAT3	72,77	BACE1	STAT3	23621	6774	Gene	Gene	regulation|nmod|START_ENTITY induces|dobj|regulation induces|nmod|END_ENTITY	Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes .
22709416	0	BACE1	32,37	Sorting_nexin_12	0,16	BACE1	Sorting nexin 12	23621	29934	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sorting_nexin_12 interacts with BACE1 and regulates BACE1-mediated APP processing .
14701757	0	BACE1	30,35	Sp1	91,94	BACE1	Sp1	23621	6667	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of BACE1 , the beta-amyloid_precursor_protein beta-secretase , by Sp1 .
23728330	0	BACE1	72,77	b-secretase	59,70	BACE1	b-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships for bergenin analogues as b-secretase -LRB- BACE1 -RRB- inhibitors .
22380629	0	BACE1	101,106	b-site_APP-cleaving_enzyme_1	71,99	BACE1	b-site APP-cleaving enzyme 1	23821(Tax:10090)	23821(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of cyclic_sulfone_hydroxyethylamines as potent and selective b-site_APP-cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors : structure-based design and in vivo reduction of amyloid b-peptides .
23981898	0	BACE1	103,108	b-site_APP-cleaving_enzyme_1	73,101	BACE1	b-site APP-cleaving enzyme 1	23821(Tax:10090)	23821(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of cyclic_sulfoxide_hydroxyethylamines as potent and selective b-site_APP-cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors : structure based design and in vivo reduction of amyloid b-peptides .
23509904	0	BACE1	56,61	b-site_APP_cleaving_enzyme_1	26,54	BACE1	b-site APP cleaving enzyme 1	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure-based design of b-site_APP_cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors for the treatment of Alzheimer 's _ disease .
24397738	0	BACE1	98,103	b-site_amyloid_precursor_protein_cleaving_enzyme_1	46,96	BACE1	b-site amyloid precursor protein cleaving enzyme 1	100135485(Tax:10141)	100135485(Tax:10141)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of 7-tetrahydropyran-2-yl_chromans : b-site_amyloid_precursor_protein_cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors that reduce amyloid b-protein -LRB- Ab -RRB- in the central nervous system .
15916426	0	BACE1	38,43	beta-secretase	22,36	BACE1	beta-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Virtual screening for beta-secretase -LRB- BACE1 -RRB- inhibitors reveals the importance of protonation states at Asp32 and Asp228 .
17429617	0	BACE1	82,87	beta-secretase	66,80	BACE1	beta-secretase	29392(Tax:10116)	29392(Tax:10116)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase -LRB- BACE1 -RRB- proteins and activity in vivo in the rat retina .
19959359	0	BACE1	99,104	beta-secretase	83,97	BACE1	beta-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery and initial optimization of 5,5 ' - disubstituted_aminohydantoins as potent beta-secretase -LRB- BACE1 -RRB- inhibitors .
19968289	0	BACE1	105,110	beta-secretase	89,103	BACE1	beta-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design and synthesis of 5,5 ' - disubstituted_aminohydantoins as potent and selective human beta-secretase -LRB- BACE1 -RRB- inhibitors .
20223661	0	BACE1	78,83	beta-secretase	62,76	BACE1	beta-secretase	23621	23621	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Novel pyrrolyl_2-aminopyridines as potent and selective human beta-secretase -LRB- BACE1 -RRB- inhibitors .
17470798	0	BACE1	48,53	beta-site_APP_cleaving_enzyme_1	15,46	BACE1	beta-site APP cleaving enzyme 1	23821(Tax:10090)	23821(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of beta-site_APP_cleaving_enzyme_1 -LRB- BACE1 -RRB- in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity .
25411915	0	BACE1	105,110	beta-site_amyloid_precursor_protein_cleaving_enzyme_1	50,103	BACE1	beta-site amyloid precursor protein cleaving enzyme 1	29392(Tax:10116)	29392(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	8-Tetrahydropyran-2-yl_chromans : highly selective beta-site_amyloid_precursor_protein_cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors .
22989333	0	BACE1	88,93	beta_amyloid_cleaving_enzyme-1	56,86	BACE1	beta amyloid cleaving enzyme-1	29392(Tax:10116)	29392(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design and validation of bicyclic_iminopyrimidinones as beta_amyloid_cleaving_enzyme-1 -LRB- BACE1 -RRB- inhibitors : conformational constraint to favor a bioactive conformation .
12054507	0	BACE1	0,5	nicastrin	21,30	BACE1	nicastrin	23621	23385	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BACE1 interacts with nicastrin .
19196715	0	BACE1	61,66	presenilin_1	7,19	BACE1	presenilin 1	23821(Tax:10090)	19164(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Mutant presenilin_1 increases the expression and activity of BACE1 .
11301010	0	BACH1	0,5	BRCA1	62,67	BACH1	BRCA1	571	672	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BACH1 , a novel helicase-like protein , interacts directly with BRCA1 and contributes to its DNA repair function .
11920628	0	BACH1	20,25	BRCA1	34,39	BACH1	BRCA1	571	672	Gene	Gene	gene|compound|START_ENTITY gene|nmod|families families|compound|END_ENTITY	No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22 .
15125843	0	BACH1	50,55	BRCA1	33,38	BACH1	BRCA1	571	672	Gene	Gene	phosphopeptide|compound|START_ENTITY bound|nmod|phosphopeptide END_ENTITY|acl|bound	Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide : implications for signaling .
15133502	0	BACH1	75,80	BRCA1	27,32	BACH1	BRCA1	571	672	Gene	Gene	recognition|nmod|START_ENTITY BRCT|dobj|recognition BRCT|nsubj|Structure Structure|nmod|END_ENTITY	Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer .
15242590	0	BACH1	20,25	BRCA1	56,61	BACH1	BRCA1	571	672	Gene	Gene	basis|nmod|START_ENTITY phosphopeptide|nsubj|basis phosphopeptide|nmod|domains domains|compound|END_ENTITY	Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains .
23225146	0	BACH1	27,32	BRIP1	20,25	BACH1	BRIP1	571	64979	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between BRIP1 -LRB- BACH1 -RRB- polymorphisms and breast_cancer risk : a meta-analysis .
23225146	0	BACH1	27,32	BRIP1	20,25	BACH1	BRIP1	571	64979	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between BRIP1 -LRB- BACH1 -RRB- polymorphisms and breast_cancer risk : a meta-analysis .
18550526	0	BACH1	0,5	HMOX1	33,38	BACH1	HMOX1	571	3162	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite .
17942419	0	BACH1	90,95	Heme_oxygenase-1	0,16	BACH1	Heme oxygenase-1	571	3162	Gene	Gene	inactivation|nmod|START_ENTITY requires|dobj|inactivation requires|nsubj|induction induction|amod|END_ENTITY	Heme_oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1 .
18769450	0	BACH2	54,59	IL-2	14,18	BACH2	IL-2	60468	3558	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of IL-2 expression by transcription factor BACH2 in umbilical cord blood CD4 + T cells .
24608439	0	BACH2	0,5	PTPN2	150,155	BACH2	PTPN2	60468	5771	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	BACH2 , a candidate risk gene for type 1 diabetes , regulates apoptosis in pancreatic b-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2 .
12691738	0	BAD	81,84	Akt	76,79	BAD	Akt	572	207	Gene	Gene	GSK-3beta|appos|START_ENTITY GSK-3beta|compound|END_ENTITY	Ceramide-induced neuronal_apoptosis is associated with dephosphorylation of Akt , BAD , FKHR , GSK-3beta , and induction of the mitochondrial-dependent intrinsic caspase pathway .
16690206	0	BAD	78,81	BAR	117,120	BAD	BAR	572	51283	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Sensitive Ewing_sarcoma and neuroblastoma cell lines have increased levels of BAD expression and decreased levels of BAR expression compared to resistant cell lines .
25499972	0	BAD	22,25	BCL-2	0,5	BAD	BCL-2	572	596	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	BCL-2 family protein , BAD is down-regulated in breast_cancer and inhibits cell invasion .
20647330	0	BAD	0,3	BCL2	34,38	BAD	BCL2	572	596	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	BAD , a proapoptotic member of the BCL2 family , is a potential therapeutic target in hepatocellular_carcinoma .
11483855	0	BAD	20,23	Bcl-2	61,66	BAD	Bcl-2	572	596	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|proteins proteins|compound|END_ENTITY	Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis .
11699408	0	BAD	0,3	Bcl-2	47,52	BAD	Bcl-2	572	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|cells cells|acl|over-expressing over-expressing|dobj|END_ENTITY	BAD induces apoptosis in cells over-expressing Bcl-2 or Bcl-xL without loss of mitochondrial membrane potential .
12404123	0	BAD	34,37	Bcl-2	106,111	BAD	Bcl-2	572	596	Gene	Gene	transduces|nsubj|START_ENTITY transduces|dobj|signals signals|nmod|interaction interaction|nmod|END_ENTITY	The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2 .
9389536	0	BAD	102,105	Bcl-2	42,47	BAD	Bcl-2	64639(Tax:10116)	24224(Tax:10116)	Gene	Gene	associated_death_promoter|appos|START_ENTITY Expression|dep|associated_death_promoter Expression|nmod|Bcl-XL/Bcl Bcl-XL/Bcl|amod|END_ENTITY	Expression and function of a proapoptotic Bcl-2 family member Bcl-XL/Bcl -2 - associated_death_promoter -LRB- BAD -RRB- in rat ovary .
15736430	0	BAD	30,33	Chkl	0,4	BAD	Chkl	572	1120	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Chkl binds and phosphorylates BAD protein .
15121878	0	BAD	77,80	ERK	144,147	BAD	ERK	572	5594	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|dep|pathways pathways|acl|requiring requiring|advcl|signaling signaling|nmod|END_ENTITY	Estradiol abrogates apoptosis in breast_cancer cells through inactivation of BAD : Ras-dependent nongenomic pathways requiring signaling through ERK and Akt .
12189144	0	BAD	38,41	JNK	0,3	BAD	JNK	64639(Tax:10116)	116554(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery .
14967141	0	BAD	86,89	JNK	0,3	BAD	JNK	572	5599	Gene	Gene	phosphorylation|nmod|START_ENTITY apoptosis|nmod|phosphorylation suppresses|dobj|apoptosis suppresses|nsubj|END_ENTITY	JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD .
20596645	0	BAD	76,79	NF-kappaB	95,104	BAD	NF-kappaB	572	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	AF1q enhancement of gamma irradiation-induced apoptosis by up-regulation of BAD expression via NF-kappaB in human squamous_carcinoma A431 cells .
10383455	0	BAD	67,70	Tumor_necrosis_factor	0,21	BAD	Tumor necrosis factor	572	7124	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Tumor_necrosis_factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH_kinase-dependent pathway .
10924254	0	BAD	97,100	bcl-2	19,24	BAD	bcl-2	572	596	Gene	Gene	protein|compound|START_ENTITY destruction|nmod|protein facilitates|dobj|destruction facilitates|nsubj|combination combination|nmod|expression expression|amod|END_ENTITY	The combination of bcl-2 expression and NGF-deprivation facilitates the selective destruction of BAD protein in living sympathetic neurons .
17670745	0	BAD	49,52	cyclin_D1	68,77	BAD	cyclin D1	572	595	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Breast_cancer cell proliferation is inhibited by BAD : regulation of cyclin_D1 .
22096607	0	BAD	45,48	p21-Activated_kinase_1	0,22	BAD	p21-Activated kinase 1	572	5058	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	p21-Activated_kinase_1 -LRB- Pak1 -RRB- phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112 .
14645565	0	BAF	34,37	Gag	48,51	BAF	Gag	8815	155030(Tax:11676)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Barrier-to-autointegration_factor BAF binds p55 Gag and matrix and is a host component of human_immunodeficiency_virus_type_1 virions .
22408686	0	BAF-250a	25,33	ARID1A	17,23	BAF-250a	ARID1A	8289	8289	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Does the Loss of ARID1A -LRB- BAF-250a -RRB- Expression in Endometrial_Clear_Cell_Carcinomas Have Any Clinicopathologic Significance ?
16199878	0	BAF155	96,102	BAF57	134,139	BAF155	BAF57	6599	6605	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation : BAF155 and BAF170 limit expression of BAF57 .
20935679	0	BAF155	25,31	Srg3	0,4	BAF155	Srg3	20588(Tax:10090)	20588(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Srg3 , a mouse homolog of BAF155 , is a novel p53 target and acts as a tumor suppressor by modulating p21 -LRB- WAF1/CIP1 -RRB- expression .
18339845	0	BAF180	0,6	p21	34,37	BAF180	p21	55193	1026	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|induction induction|amod|END_ENTITY	BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast_cancer .
26992241	0	BAF180	0,6	p21	85,88	BAF180	p21	66923(Tax:10090)	12575(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21 .
24557437	0	BAF250a	50,57	ARID1A	59,65	BAF250a	ARID1A	8289	8289	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The clinicopathologic significance of the loss of BAF250a -LRB- ARID1A -RRB- expression in endometrial_carcinoma .
26589513	0	BAF250a	38,45	ARID1A	47,53	BAF250a	ARID1A	8289	8289	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	The Clinicopathologic Significance of BAF250a -LRB- ARID1A -RRB- Expression in Hepatocellular_Carcinoma .
17878219	0	BAF53	0,5	p53	21,24	BAF53	p53	86	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BAF53 interacts with p53 and functions in p53-mediated p21-gene transcription .
16199878	0	BAF57	134,139	BAF155	96,102	BAF57	BAF155	6605	6599	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation : BAF155 and BAF170 limit expression of BAF57 .
18303029	0	BAF60a	0,6	p53	22,25	BAF60a	p53	6602	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BAF60a interacts with p53 to recruit the SWI/SNF complex .
21169521	0	BAFF	19,23	AID	32,35	BAFF	AID	24099(Tax:10090)	11628(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP -1 pathways .
18713867	0	BAFF	0,4	Akt	15,18	BAFF	Akt	24099(Tax:10090)	11651(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells .
23878841	0	BAFF	45,49	B-cell_activating_factor	19,43	BAFF	B-cell activating factor	10673	10673	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Salivary and serum B-cell_activating_factor -LRB- BAFF -RRB- levels after hydroxychloroquine treatment in primary Sj gren 's syndrome .
25656062	0	BAFF	42,46	B-cell_activating_factor	16,40	BAFF	B-cell activating factor	10673	10673	Gene	Gene	presence|appos|START_ENTITY presence|nmod|END_ENTITY	The presence of B-cell_activating_factor -LRB- BAFF -RRB- in umbilical cord blood in both healthy and pre-eclamptic pregnancies and in human breast milk .
16385515	0	BAFF	15,19	BAFF	73,77	BAFF	BAFF	10673	10673	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Elevated serum BAFF levels in patients with systemic_sclerosis : enhanced BAFF signaling in systemic_sclerosis B lymphocytes .
16385515	0	BAFF	73,77	BAFF	15,19	BAFF	BAFF	10673	10673	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Elevated serum BAFF levels in patients with systemic_sclerosis : enhanced BAFF signaling in systemic_sclerosis B lymphocytes .
11509692	0	BAFF	73,77	BAFF-R	0,6	BAFF	BAFF-R	24099(Tax:10090)	72049(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY receptor|acl:relcl|interacts END_ENTITY|appos|receptor	BAFF-R , a newly identified TNF receptor that specifically interacts with BAFF .
12796483	0	BAFF	86,90	BAFF-R	51,57	BAFF	BAFF-R	24099(Tax:10090)	72049(Tax:10090)	Gene	Gene	antagonists|nmod|START_ENTITY Comparison|nmod|antagonists Comparison|nmod|proteins proteins|nmod|END_ENTITY	Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF .
15368291	0	BAFF	0,4	BAFF-R	33,39	BAFF	BAFF-R	24099(Tax:10090)	72049(Tax:10090)	Gene	Gene	binding|advmod|START_ENTITY costimulates|amod|binding costimulates|compound|END_ENTITY	BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses .
17942754	0	BAFF	55,59	BAFF-R	13,19	BAFF	BAFF-R	10673	115650	Gene	Gene	activated|nmod|START_ENTITY activated|nmod|END_ENTITY	TACI , unlike BAFF-R , is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts .
18713867	0	BAFF	0,4	BAFF-R	35,41	BAFF	BAFF-R	24099(Tax:10090)	72049(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells .
25975951	0	BAFF	0,4	BAFF-R	78,84	BAFF	BAFF-R	10673	115650	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|interaction interaction|nmod|END_ENTITY	BAFF promotes proliferation of human mesangial cells through interaction with BAFF-R .
23923031	0	BAFF	0,4	BAFF_receptor	43,56	BAFF	BAFF receptor	10673	115650	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	BAFF controls neural cell survival through BAFF_receptor .
15095277	0	BAFF	14,18	BLyS	20,24	BAFF	BLyS	10673	10673	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of BAFF -LRB- BLyS -RRB- in T cells infiltrating labial salivary glands from patients with Sj gren 's syndrome .
26600308	0	BAFF	43,47	B_Cell-Activating_Factor	17,41	BAFF	B Cell-Activating Factor	10673	10673	Gene	Gene	Levels|appos|START_ENTITY Levels|compound|END_ENTITY	Changes in Blood B_Cell-Activating_Factor -LRB- BAFF -RRB- Levels in Multiple_Sclerosis : A Sign of Treatment Outcome .
25479221	0	BAFF	38,42	B_cell_Activating_Factor	12,36	BAFF	B cell Activating Factor	10673	10673	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The role of B_cell_Activating_Factor -LRB- BAFF -RRB- expression on pathogenesis of nasal_polyp in chronic rhinosinusitis with nasal_polyposis .
10880534	0	BAFF	0,4	B_cell_maturation_antigen	63,88	BAFF	B cell maturation antigen	10673	608	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	BAFF binds to the tumor necrosis factor receptor-like molecule B_cell_maturation_antigen and is important for maintaining the peripheral B cell population .
22898048	0	BAFF	0,4	CD4	20,23	BAFF	CD4	10673	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|proliferation proliferation|compound|END_ENTITY	BAFF induces spleen CD4 + T cell proliferation by down-regulating phosphorylation of FOXO3A and activates cyclin_D2 and D3 expression .
23271704	0	BAFF	13,17	IFN-y	32,37	BAFF	IFN-y	10673	3458	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of BAFF expression by IFN-y via JAK/STAT signaling pathways in human intestinal epithelial cells .
24670802	0	BAFF	0,4	IL-15	16,21	BAFF	IL-15	24099(Tax:10090)	16168(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	BAFF suppresses IL-15 expression in B cells .
23686487	0	BAFF	16,20	SOCS3	0,5	BAFF	SOCS3	10673	9021	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SOCS3 regulates BAFF in human enterocytes under ribosomal stress .
17942754	0	BAFF	55,59	TACI	0,4	BAFF	TACI	10673	23495	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	TACI , unlike BAFF-R , is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts .
23620746	0	BAFF	72,76	TACI	25,29	BAFF	TACI	24099(Tax:10090)	57916(Tax:10090)	Gene	Gene	signalling|nmod|START_ENTITY induces|xcomp|signalling induces|nsubj|evidence evidence|dep|END_ENTITY	No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells .
23954794	0	BAFF	31,35	TACI	49,53	BAFF	TACI	10673	23495	Gene	Gene	binding|compound|START_ENTITY amino_acid|nmod|binding amino_acid|nmod|END_ENTITY	Identify the key amino_acid of BAFF binding with TACI .
18713867	0	BAFF-R	35,41	Akt	15,18	BAFF-R	Akt	72049(Tax:10090)	11651(Tax:10090)	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells .
11509692	0	BAFF-R	0,6	BAFF	73,77	BAFF-R	BAFF	72049(Tax:10090)	24099(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|acl:relcl|interacts interacts|nmod|END_ENTITY	BAFF-R , a newly identified TNF receptor that specifically interacts with BAFF .
12796483	0	BAFF-R	51,57	BAFF	86,90	BAFF-R	BAFF	72049(Tax:10090)	24099(Tax:10090)	Gene	Gene	proteins|nmod|START_ENTITY Comparison|nmod|proteins Comparison|nmod|antagonists antagonists|nmod|END_ENTITY	Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF .
15368291	0	BAFF-R	33,39	BAFF	0,4	BAFF-R	BAFF	72049(Tax:10090)	24099(Tax:10090)	Gene	Gene	costimulates|compound|START_ENTITY costimulates|amod|binding binding|advmod|END_ENTITY	BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses .
17942754	0	BAFF-R	13,19	BAFF	55,59	BAFF-R	BAFF	115650	10673	Gene	Gene	activated|nmod|START_ENTITY activated|nmod|END_ENTITY	TACI , unlike BAFF-R , is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts .
18713867	0	BAFF-R	35,41	BAFF	0,4	BAFF-R	BAFF	72049(Tax:10090)	24099(Tax:10090)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells .
25975951	0	BAFF-R	78,84	BAFF	0,4	BAFF-R	BAFF	115650	10673	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|nsubj|END_ENTITY	BAFF promotes proliferation of human mesangial cells through interaction with BAFF-R .
19258594	0	BAFF-R	0,6	IKKbeta	73,80	BAFF-R	IKKbeta	115650	3551	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|interaction interaction|nmod|END_ENTITY	BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells .
17154264	0	BAFF-R	52,58	TACI	0,4	BAFF-R	TACI	115650	23495	Gene	Gene	costimulated|nmod|START_ENTITY production|acl|costimulated attenuates|dobj|production attenuates|nsubj|END_ENTITY	TACI attenuates antibody production costimulated by BAFF-R and CD40 .
17942754	0	BAFF-R	13,19	TACI	0,4	BAFF-R	TACI	115650	23495	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	TACI , unlike BAFF-R , is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts .
22699762	0	BAFF-R	91,97	TACI	73,77	BAFF-R	TACI	115650	23495	Gene	Gene	TNFRSF13C|appos|START_ENTITY TNFRSF13B|appos|TNFRSF13C TNFRSF13B|appos|END_ENTITY	Three different classifications , B lymphocyte subpopulations , TNFRSF13B -LRB- TACI -RRB- , TNFRSF13C -LRB- BAFF-R -RRB- , TNFSF13 -LRB- APRIL -RRB- gene mutations , CTLA-4 and ICOS gene polymorphisms in Turkish patients with common_variable_immunodeficiency .
23923031	0	BAFF_receptor	43,56	BAFF	0,4	BAFF receptor	BAFF	115650	10673	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	BAFF controls neural cell survival through BAFF_receptor .
23455184	0	BAG	42,45	Bcl-2	14,19	BAG	Bcl-2	573	596	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian_cancer .
8943845	0	BAG-1	33,38	Interleukin-2	0,13	BAG-1	Interleukin-2	573	3558	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain .
15707960	0	BAG-1	0,5	p29	6,9	BAG-1	p29	573	25949	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian_cancer cells .
24492285	0	BAG-3	15,20	CD30	52,56	BAG-3	CD30	9531	943	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|expression expression|compound|END_ENTITY	Correlation of BAG-3 and heat_shock_protein_70 with CD30 expression in T-cell_lymphomas .
24383081	0	BAG2	4,8	PINK1	28,33	BAG2	PINK1	9532	65018	Gene	Gene	protein|compound|START_ENTITY stabilises|nsubj|protein stabilises|dobj|END_ENTITY	The BAG2 protein stabilises PINK1 by decreasing its ubiquitination .
24513209	0	BAG2	4,8	PINK1	28,33	BAG2	PINK1	9532	65018	Gene	Gene	Stabilises|compound|START_ENTITY END_ENTITY|nsubj|Stabilises	The BAG2 Protein Stabilises PINK1 By Decreasing its Ubiquitination .
23983126	0	BAG3	153,157	Bcl-2-associated_athanogene_domain_3	115,151	BAG3	Bcl-2-associated athanogene domain 3	9531	9531	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The natural compound cantharidin induces cancer cell death through inhibition of heat_shock_protein_70 -LRB- HSP70 -RRB- and Bcl-2-associated_athanogene_domain_3 -LRB- BAG3 -RRB- expression by blocking heat_shock_factor_1 -LRB- HSF1 -RRB- binding to promoters .
20018251	0	BAG3	17,21	CCT	62,65	BAG3	CCT	9531	907	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	The co-chaperone BAG3 interacts with the cytosolic chaperonin CCT : new hints for actin folding .
18469860	0	BAG3	14,18	Egr-1	22,27	BAG3	Egr-1	9531	1958	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells .
19681889	0	BAG3	130,134	JNK	18,21	BAG3	JNK	9531	5599	Gene	Gene	expression|compound|START_ENTITY suppression|nmod|expression enhances|nmod|suppression enhances|nsubj|Inhibition Inhibition|nmod|signalling signalling|compound|END_ENTITY	Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney_cancer cells by suppression of BAG3 expression .
22020323	0	BAG3	74,78	JNK	15,18	BAG3	JNK	9531	5599	Gene	Gene	expression|compound|START_ENTITY Involvement|dep|expression Involvement|nmod|END_ENTITY	Involvement of JNK and NF-kB pathways in lipopolysaccharide -LRB- LPS -RRB- - induced BAG3 expression in human monocytic cells .
23395971	0	BAG3	29,33	JNK	56,59	BAG3	JNK	9531	5599	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	The combination of silencing BAG3 and inhibition of the JNK pathway enhances hyperthermia sensitivity in human oral_squamous_cell_carcinoma cells .
26654586	0	BAG3	0,4	MAP1LC3B	21,29	BAG3	MAP1LC3B	9531	81631	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism .
19006120	0	BAG3	35,39	MG132	21,26	BAG3	MG132	9531	875581(Tax:243273)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Proteasome inhibitor MG132 induces BAG3 expression through activation of heat_shock factor 1 .
21316839	0	BAG3	0,4	MMP-2	51,56	BAG3	MMP-2	9531	4313	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BAG3 -LRB- BCL2-associated_athanogene_3 -RRB- interacts with MMP-2 to positively regulate invasion by ovarian_carcinoma cells .
24992675	0	BAG3	0,4	Mcl-1	17,22	BAG3	Mcl-1	9531	4170	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian_cancer .
23108398	0	BAG3	34,38	PKC	0,3	BAG3	PKC	100758034	100774348	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|nsubj|phosphorylation END_ENTITY|parataxis|induces	PKC - mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid_cancer FRO cells .
24140207	0	BAG3	0,4	c-Jun	23,28	BAG3	c-Jun	9531	3725	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	BAG3 is upregulated by c-Jun and stabilizes JunD .
12461691	0	BAGE	4,8	B_melanoma_antigen	10,28	BAGE	B melanoma antigen	574	574	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	New BAGE -LRB- B_melanoma_antigen -RRB- genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile .
12890744	0	BAGE	88,92	FHIT	41,45	BAGE	FHIT	574	2272	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Analysis of the tumour suppressor genes , FHIT and WT-1 , _ and_the_tumour rejection genes , BAGE , GAGE-1 / 2 , HAGE , MAGE-1 , and MAGE-3 , in benign and malignant_neoplasms of the salivary glands .
15225653	0	BAI3	55,59	brain-specific_angiogenesis_inhibitor_3	14,53	BAI3	brain-specific angiogenesis inhibitor 3	210933(Tax:10090)	210933(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of brain-specific_angiogenesis_inhibitor_3 -LRB- BAI3 -RRB- in normal brain and implications for BAI3 in ischemia-induced brain_angiogenesis and malignant_glioma .
9696231	0	BAK	61,64	BCL-2	40,45	BAK	BCL-2	578	596	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	Elevated expression of the proapoptotic BCL-2 family member , BAK , in the human endometrium coincident with apoptosis during the secretory phase of the cycle .
24074954	0	BAK	29,32	BID	0,3	BAK	BID	578	637	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	BID preferentially activates BAK while BIM preferentially activates BAX , affecting chemotherapy response .
20605789	0	BAK	26,29	Bcl-2	59,64	BAK	Bcl-2	578	596	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Conformational changes in BAK , a pore-forming proapoptotic Bcl-2 family member , upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers .
16732318	0	BAK	16,19	Sp3	74,77	BAK	Sp3	578	6670	Gene	Gene	Upregulation|nmod|START_ENTITY associated|nsubjpass|Upregulation associated|nmod|END_ENTITY	Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding .
10352342	0	BAK	13,16	p53	0,3	BAK	p53	578	7157	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	p53 enhances BAK and CD95 expression in human malignant_glioma cells but does not enhance CD95L-induced apoptosis .
12150929	0	BAK1	0,4	BRI1	70,74	BAK1	BRI1	829480(Tax:3702)	830095(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BAK1 , an Arabidopsis LRR receptor-like protein kinase , interacts with BRI1 and modulates brassinosteroid signaling .
21496456	0	BAMBI	66,71	Adiponectin	0,11	BAMBI	Adiponectin	25805	9370	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes .
19758997	0	BAMBI	6,11	Smad7	28,33	BAMBI	Smad7	25805	4092	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling .
18386821	0	BAMBI	75,80	bone_morphogenetic_protein	39,65	BAMBI	bone morphogenetic protein	25805	649	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression and regulation of the decoy bone_morphogenetic_protein receptor BAMBI in the developing avian face .
25658920	0	BANF1	0,5	MicroRNA-203	41,53	BANF1	MicroRNA-203	8815	406986	Gene	Gene	Downregulated|nsubjpass|START_ENTITY Downregulated|nmod|END_ENTITY	BANF1 Is Downregulated by IRF1-Regulated MicroRNA-203 in Cervical_Cancer .
24227780	0	BANK1	0,5	IL-6	27,31	BANK1	IL-6	242248(Tax:10090)	16193(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|secretion secretion|compound|END_ENTITY	BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway .
19644876	0	BANK1	38,43	STAT4	15,20	BANK1	STAT4	55024	6775	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of STAT4 and BLK , but not BANK1 or IRF5 , with primary_antiphospholipid_syndrome .
23555801	0	BANK1	0,5	phospholipase_C_gamma_2	26,49	BANK1	phospholipase C gamma 2	55024	5336	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	BANK1 and BLK act through phospholipase_C_gamma_2 in B-cell signaling .
26118501	0	BAP1	22,26	BCR-ABL	41,48	BAP1	BCR-ABL	8314	25	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	The downregulation of BAP1 expression by BCR-ABL reduces the stability of BRCA1 in chronic_myeloid_leukemia .
26246155	0	BAP1	63,67	BRCA1_associated_protein-1	35,61	BAP1	BRCA1 associated protein-1	8314	8314	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Frequent genomic rearrangements of BRCA1_associated_protein-1 -LRB- BAP1 -RRB- gene in Japanese malignant mesothelioma-characterization of deletions at exon level .
19815555	0	BAP1	28,32	HCF-1	76,81	BAP1	HCF-1	8314	3054	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1 .
24166983	0	BAP1	48,52	PBRM1	41,46	BAP1	PBRM1	8314	55193	Gene	Gene	KDM6A|appos|START_ENTITY KDM6A|appos|END_ENTITY	Clinical and pathological impact of VHL , PBRM1 , BAP1 , SETD2 , KDM6A , and JARID1c in clear_cell_renal_cell_carcinoma .
26300218	6	BAP1	952,956	PBRM1	945,950	BAP1	PBRM1	8314	55193	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	RESULTS : PBRM1 and BAP1 expression was PBRM1 + BAP1 + in 40.1 % of tumors , PBRM1 - BAP1 + in 48.6 % , PBRM1 + BAP1 - in 8.7 % and PBRM1 - BAP1 - in 1.8 % .
24166983	0	BAP1	48,52	SETD2	54,59	BAP1	SETD2	8314	29072	Gene	Gene	KDM6A|appos|START_ENTITY KDM6A|appos|END_ENTITY	Clinical and pathological impact of VHL , PBRM1 , BAP1 , SETD2 , KDM6A , and JARID1c in clear_cell_renal_cell_carcinoma .
18555783	0	BAP31	0,5	Sec61	21,26	BAP31	Sec61	10134	29927	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex .
26181365	0	BAPKO_0422	44,54	Factor-H	67,75	BAPKO_0422	Factor-H	4227740(Tax:390236)	3075	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The Borrelia_afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning b-barrel .
16690206	0	BAR	117,120	BAD	78,81	BAR	BAD	51283	572	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Sensitive Ewing_sarcoma and neuroblastoma cell lines have increased levels of BAD expression and decreased levels of BAR expression compared to resistant cell lines .
11560894	0	BAR-1	59,64	beta-catenin	37,49	BAR-1	beta-catenin	180982(Tax:6239)	31151(Tax:7227)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	The divergent Caenorhabditis_elegans beta-catenin proteins BAR-1 , WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo .
11773071	0	BARD1	59,64	BRCA1	70,75	BRCA1	BRCA1	672	672	Gene	Gene	interaction|nmod|START_ENTITY required|nmod|interaction required|nmod|END_ENTITY	Identification of residues required for the interaction of BARD1 with BRCA1 .
14560035	0	BARD1	0,5	BRCA1	24,29	BARD1	BRCA1	580	672	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks .
14976165	0	BARD1	8,13	BRCA1	0,5	BARD1	BRCA1	580	672	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures , dependent on K6 of ubiquitin , in cells during DNA replication and repair .
15265711	0	BARD1	0,5	BRCA1	16,21	BARD1	BRCA1	580	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nummod|END_ENTITY	BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention .
26315354	0	BARD1	33,38	BRIP1	26,31	BARD1	BRIP1	580	83990	Gene	Gene	PALB2|appos|START_ENTITY PALB2|compound|END_ENTITY	Germline Mutations in the BRIP1 , BARD1 , PALB2 , and NBN Genes in Women With Ovarian_Cancer .
10477523	0	BARD1	43,48	CstF-50	77,84	BARD1	CstF-50	580	1477	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 .
18842000	0	BARD1	4,9	CstF-50	83,90	BARD1	CstF-50	580	1477	Gene	Gene	C-terminal|compound|START_ENTITY domain|nsubj|C-terminal domain|nmod|END_ENTITY	The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50 .
22745590	0	BART	0,4	Rac1	100,104	BART	Rac1	23568	5879	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	BART inhibits pancreatic_cancer cell invasion by Rac1 inactivation through direct binding to active Rac1 .
22745590	0	BART	0,4	Rac1	49,53	BART	Rac1	23568	5879	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|invasion invasion|nmod|inactivation inactivation|amod|END_ENTITY	BART inhibits pancreatic_cancer cell invasion by Rac1 inactivation through direct binding to active Rac1 .
11585719	0	BARX2	0,5	cadherin_6	14,24	BARX2	cadherin 6	8538	1004	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	BARX2 induces cadherin_6 expression and is a functional suppressor of ovarian_cancer progression .
2683089	0	BAS2	79,83	HIS4	35,39	BAS2	HIS4	851452(Tax:4932)	850327(Tax:4932)	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|transcription transcription|nummod|END_ENTITY	BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2 .
11380625	0	BAT1	22,26	MHC	12,15	BAT1	MHC	10212	3133	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The central MHC gene , BAT1 , may encode a protein that down-regulates cytokine production .
25091272	0	BAT3	27,31	TIM-3	15,20	BAT3	TIM-3	7917	84868	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for the TIM-3 / GAL-9 / BAT3 pathway in determining the clinical phenotype of multiple_sclerosis .
14960581	0	BAT3	77,81	caspase-3	55,64	BAT3	caspase-3	7917	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3 .
12719594	0	BATF	47,51	EBNA2	0,5	BATF	EBNA2	10538	17494192	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	EBNA2 and activated Notch induce expression of BATF .
19223395	0	BATH-42	21,28	RIC-3	44,49	BATH-42	RIC-3	176152(Tax:6239)	177570(Tax:6239)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors .
18793611	0	BAX	73,76	ASPP2	22,27	BAX	ASPP2	581	7159	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
18089567	0	BAX	15,18	BAX	43,46	BAX	BAX	581	581	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|Interaction Interaction|compound|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	BAX	43,46	BAX	15,18	BAX	BAX	581	581	Gene	Gene	Interaction|compound|START_ENTITY absence|nmod|Interaction END_ENTITY|nmod|absence	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
11340567	0	BAX	71,74	BCL-2	65,70	BAX	BCL-2	581	596	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Radiation-induced apoptosis in human myeloma cell line increases BCL-2 / BAX dimer formation and does not result in BAX/BAX homodimerization .
11583631	0	BAX	63,66	BCL-2	0,5	BAX	BCL-2	581	596	Gene	Gene	preventing|dobj|START_ENTITY molecules|acl|preventing sequester|dobj|molecules sequester|nsubj|BCL-X BCL-X|compound|END_ENTITY	BCL-2 , BCL-X -LRB- L -RRB- sequester BH3 domain-only molecules preventing BAX - and BAK-mediated mitochondrial apoptosis .
12421568	0	BAX	39,42	BCL-2	33,38	BAX	BCL-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Interleukin-1_beta increases the BCL-2 / BAX ratio in Kaposi 's _ sarcoma cells .
12898509	0	BAX	76,79	BCL-2	48,53	BAX	BCL-2	581	596	Gene	Gene	independent|nmod|START_ENTITY occurs|dobj|independent occurs|nsubj|END_ENTITY	Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK .
16987815	0	BAX	94,97	BCL-2	24,29	BAX	BCL-2	581	596	Gene	Gene	activation|nmod|START_ENTITY sufficient|nmod|activation sufficient|nsubj|homology homology|compound|END_ENTITY	A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro .
17905238	0	BAX	24,27	BCL-2	18,23	BAX	BCL-2	581	596	Gene	Gene	ratio|compound|START_ENTITY Modulation|dep|ratio Modulation|nmod|END_ENTITY	Modulation of the BCL-2 / BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblasts .
18174961	0	BAX	56,59	BCL-2	50,55	BAX	BCL-2	581	596	Gene	Gene	formation|dep|START_ENTITY formation|nmod|END_ENTITY	Enhanced micronucleus formation and modulation of BCL-2 : BAX in MCF-7 cells after exposure to binary mixtures .
18534994	0	BAX	99,102	BCL-2	93,98	BAX	BCL-2	581	596	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	The developing human ovary : immunohistochemical analysis of germ-cell-specific VASA protein , BCL-2 / BAX expression balance and apoptosis .
10778970	0	BAX	0,3	BCL2	51,55	BAX	BCL2	581	596	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|impact impact|nmod|expression expression|nummod|END_ENTITY	BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute_myelogenous_leukemia .
18818203	0	BAX	40,43	BCL2	15,19	BAX	BCL2	581	596	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|function function|nmod|END_ENTITY	G0 function of BCL2 and BCL-xL requires BAX , BAK , and p27 phosphorylation by Mirk , revealing a novel role of BAX_and_BAK in quiescence regulation .
9682022	0	BAX	36,39	BCL2	17,21	BAX	BCL2	581	596	Gene	Gene	START_ENTITY|nsubj|Placement Placement|nmod|member member|compound|END_ENTITY	Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation .
16987815	0	BAX	94,97	BID	20,23	BAX	BID	581	637	Gene	Gene	activation|nmod|START_ENTITY sufficient|nmod|activation sufficient|nsubj|homology homology|compound|END_ENTITY	A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro .
19664589	0	BAX	94,97	BID	123,126	BAX	BID	581	637	Gene	Gene	START_ENTITY|acl|activated activated|nmod|END_ENTITY	Dissimilar mechanisms of cytochrome_c release induced by octyl_glucoside-activated BAX and by BAX activated with truncated BID .
20374575	0	BAX	135,138	Bcl-2	141,146	BAX	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Coenzyme_Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX / Bcl-2 ratio .
20621101	0	BAX	47,50	Bcl2	16,20	BAX	Bcl2	581	596	Gene	Gene	insertion|compound|START_ENTITY inhibits|dobj|insertion inhibits|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria .
18793611	0	BAX	73,76	DDA3	11,15	BAX	DDA3	581	84722	Gene	Gene	activation|compound|START_ENTITY ASPP2|nmod|activation ASPP2|nsubj|binds binds|compound|END_ENTITY	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
18089567	0	BAX	15,18	MCL-1	0,5	BAX	MCL-1	581	4170	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	BAX	15,18	MCL-1	37,42	BAX	MCL-1	581	4170	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|Interaction Interaction|compound|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	BAX	43,46	MCL-1	0,5	BAX	MCL-1	581	4170	Gene	Gene	Interaction|compound|START_ENTITY absence|nmod|Interaction BAX|nmod|absence inhibits|dobj|BAX inhibits|nsubj|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	BAX	43,46	MCL-1	37,42	BAX	MCL-1	581	4170	Gene	Gene	Interaction|compound|START_ENTITY Interaction|compound|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
24260268	0	BAX	33,36	MCL-1ES	0,7	BAX	MCL-1ES	581	4170	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	MCL-1ES induces MCL-1L-dependent BAX - and BAK-independent mitochondrial apoptosis .
26286430	0	BAX	56,59	P53	42,45	BAX	P53	581	7157	Gene	Gene	Expression|compound|START_ENTITY Effect|dep|Expression Effect|nmod|END_ENTITY	Effect of Cnidium_Lactone on Serum Mutant P53 and BCL-2 / BAX Expression in Human Prostate_Cancer Cells PC-3 Tumor-Bearing BALB/C Nude Mouse Model .
15273770	0	BAX	56,59	PCNA	43,47	BAX	PCNA	581	5111	Gene	Gene	Bcl-2|dep|START_ENTITY Bcl-2|dep|END_ENTITY	Expression of biomolecular markers -LRB- Ki-67 , PCNA , Bcl-2 , BAX , BclX , VEGF -RRB- in breast_tumors .
25338572	0	BAX	65,68	PTEN	70,74	BAX	PTEN	581	5728	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2 / BAX , PTEN -RSB- .
25338572	0	BAX	65,68	TIEG1	12,17	BAX	TIEG1	581	7071	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2 / BAX , PTEN -RSB- .
15273770	0	BAX	56,59	VEGF	67,71	BAX	VEGF	581	7422	Gene	Gene	Bcl-2|dep|START_ENTITY Bcl-2|dep|END_ENTITY	Expression of biomolecular markers -LRB- Ki-67 , PCNA , Bcl-2 , BAX , BclX , VEGF -RRB- in breast_tumors .
19664589	0	BAX	83,86	cytochrome_c	25,37	BAX	cytochrome c	581	54205	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|mechanisms mechanisms|nmod|release release|amod|END_ENTITY	Dissimilar mechanisms of cytochrome_c release induced by octyl_glucoside-activated BAX and by BAX activated with truncated BID .
9826721	0	BAX	115,118	p21	111,114	BAX	p21	581	644914	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 -LRB- BAX -RRB- expression .
11278953	0	BAX	93,96	p53	29,32	BAX	p53	581	7157	Gene	Gene	promoter|compound|START_ENTITY activate|dobj|promoter cofactor|acl|activate requires|dobj|cofactor requires|nsubj|END_ENTITY	The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter .
17426704	0	BAX	187,190	p53	11,14	BAX	p53	581	7157	Gene	Gene	impact|nmod|START_ENTITY Studies|dep|impact Studies|nmod|END_ENTITY	Studies on p53 , BAX and Bcl-2 protein expression and microsatellite instability in stage III -LRB- UICC -RRB- colon_cancer treated by adjuvant chemotherapy : major prognostic impact of proapoptotic BAX .
18793611	0	BAX	73,76	p53	0,3	BAX	p53	581	7157	Gene	Gene	activation|compound|START_ENTITY ASPP2|nmod|activation ASPP2|nsubj|binds binds|compound|END_ENTITY	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
23071787	0	BAX	104,107	p53	22,25	BAX	p53	581	7157	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|allele allele|nmod|polymorphism polymorphism|compound|END_ENTITY	The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21 , and increased breast_cancer risk .
23836939	0	BAX	32,35	p53	13,16	BAX	p53	581	7157	Gene	Gene	element|compound|START_ENTITY binding|nmod|element END_ENTITY|amod|binding	Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion .
26236013	0	BAX	61,64	p53	48,51	BAX	p53	581	7157	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis .
9826721	0	BAX	115,118	p53	97,100	BAX	p53	581	7157	Gene	Gene	expression|appos|START_ENTITY induce|dobj|expression associated|xcomp|induce associated|nmod|failure failure|nmod|END_ENTITY	The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 -LRB- BAX -RRB- expression .
19328063	0	BAX_inhibitor-1	0,15	IRE1alpha	64,73	BAX inhibitor-1	IRE1alpha	110213(Tax:10090)	78943(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	BAX_inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha .
15314041	0	BAZF	0,4	CD4	41,44	BAZF	CD4	12029(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|cells cells|compound|END_ENTITY	BAZF is required for activation of naive CD4 T cells by TCR triggering .
11179306	0	BBI16	6,11	VraA	0,4	BBI16	VraA	1194194(Tax:224326)	1194194(Tax:224326)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	VraA -LRB- BBI16 -RRB- protein of Borrelia_burgdorferi is a surface-exposed antigen with a repetitive motif that confers partial protection against experimental Lyme_borreliosis .
26518167	0	BBS10	154,159	BBS2	130,134	BBS10	BBS2	1194506(Tax:224326)	583	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS10	154,159	BBS4	136,140	BBS10	BBS4	1194506(Tax:224326)	585	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS10	154,159	BBS7	142,146	BBS10	BBS7	1194506(Tax:224326)	55212	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS10	154,159	BBS9	148,152	BBS10	BBS9	1194506(Tax:224326)	27241	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
16606853	0	BBS11	113,118	E3_ubiquitin_ligase	59,78	BBS11	E3 ubiquitin ligase	1194518(Tax:224326)	158506	Gene	Gene	gene|appos|START_ENTITY END_ENTITY|nmod|gene	Homozygosity mapping with SNP arrays identifies TRIM32 , an E3_ubiquitin_ligase , as a Bardet-Biedl_syndrome gene -LRB- BBS11 -RRB- .
23692385	0	BBS17	88,93	LZTFL1	80,86	BBS17	LZTFL1	1194524(Tax:224326)	54585	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Mesoaxial polydactyly is a major feature in Bardet-Biedl_syndrome patients with LZTFL1 -LRB- BBS17 -RRB- mutations .
26518167	0	BBS2	130,134	BBS10	154,159	BBS2	BBS10	583	1194506(Tax:224326)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS2	130,134	BBS4	136,140	BBS2	BBS4	583	585	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS2	130,134	BBS7	142,146	BBS2	BBS7	583	55212	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS2	130,134	BBS9	148,152	BBS2	BBS9	583	27241	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
24550735	0	BBS4	53,57	AZI1	33,37	BBS4	AZI1	768303(Tax:7955)	563066(Tax:7955)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome .
26518167	0	BBS4	136,140	BBS10	154,159	BBS4	BBS10	585	1194506(Tax:224326)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS4	136,140	BBS2	130,134	BBS4	BBS2	585	583	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS4	136,140	BBS7	142,146	BBS4	BBS7	585	55212	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS4	136,140	BBS9	148,152	BBS4	BBS9	585	27241	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
15497446	0	BBS4	88,92	Bardet-Biedl_syndrome_4	58,81	BBS4	Bardet-Biedl syndrome 4	585	585	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and characterization of a splice variant of human Bardet-Biedl_syndrome_4 gene -LRB- BBS4 -RRB- .
26867008	0	BBS5	45,49	Bardet-Biedl_Syndrome_5	20,43	BBS5	Bardet-Biedl Syndrome 5	72569(Tax:10090)	72569(Tax:10090)	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	A Splice Variant of Bardet-Biedl_Syndrome_5 -LRB- BBS5 -RRB- Protein that Is Selectively Expressed in Retina .
26518167	0	BBS7	142,146	BBS10	154,159	BBS7	BBS10	55212	1194506(Tax:224326)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS7	142,146	BBS2	130,134	BBS7	BBS2	55212	583	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS7	142,146	BBS4	136,140	BBS7	BBS4	55212	585	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS7	142,146	BBS9	148,152	BBS7	BBS9	55212	27241	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS9	148,152	BBS10	154,159	BBS9	BBS10	27241	1194506(Tax:224326)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS9	148,152	BBS2	130,134	BBS9	BBS2	27241	583	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS9	148,152	BBS4	136,140	BBS9	BBS4	27241	585	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
26518167	0	BBS9	148,152	BBS7	142,146	BBS9	BBS7	27241	55212	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Targeted multi-gene panel testing for the diagnosis of Bardet_Biedl_syndrome : Identification of nine novel mutations across BBS1 , BBS2 , BBS4 , BBS7 , BBS9 , BBS10 genes .
19031272	0	BCA-1	19,24	CXCL13	11,17	BCA-1	CXCL13	10563	10563	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for CXCL13 -LRB- BCA-1 -RRB- in pregnancy and intra-amniotic_infection / inflammation .
22187460	0	BCAP	34,38	B-cell_adapter_for_PI3K	9,32	BCAP	B-cell adapter for PI3K	118788	118788	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role for B-cell_adapter_for_PI3K -LRB- BCAP -RRB- as a signaling adapter linking Toll-like receptors -LRB- TLRs -RRB- to serine/threonine kinases PI3K/Akt .
10639512	0	BCAR1	0,5	p130Cas	48,55	BCAR1	p130Cas	9564	9564	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	BCAR1 , a human homologue of the adapter protein p130Cas , and antiestrogen resistance in breast_cancer cells .
22711540	0	BCAR3	42,47	Breast_cancer_anti-estrogen_resistance_3	0,40	BCAR3	Breast cancer anti-estrogen resistance 3	8412	8412	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Breast_cancer_anti-estrogen_resistance_3 -LRB- BCAR3 -RRB- protein augments binding of the c-Src SH3 domain to Crk-associated_substrate _ -LRB- p130cas -RRB- .
16740993	0	BCAR3	22,27	CrkII	0,5	BCAR3	CrkII	8412	1398	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	CrkII associates with BCAR3 in response to endothelin-1 in human glomerular mesangial cells .
22801373	0	BCAR3	56,61	Protein_tyrosine_phosphatase_a	0,30	BCAR3	Protein tyrosine phosphatase a	8412	5786	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	Protein_tyrosine_phosphatase_a phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions .
26319152	0	BCAS2	0,5	HSF4	21,25	BCAS2	HSF4	10286	3299	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination .
17150414	0	BCATc	57,62	branched_chain_aminotransferase	24,55	BCATc	branched chain aminotransferase	12035(Tax:10090)	12035(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cytosolic branched_chain_aminotransferase -LRB- BCATc -RRB- mRNA in the developing mouse brain .
19653894	0	BCCIP	15,20	BRCA2	24,29	BCCIP	BRCA2	56647	675	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of BCCIP , a BRCA2 interacting protein , in astrocytomas .
2887297	0	BCDF	78,82	B-cell_differentiation_factor	47,76	BCDF	B-cell differentiation factor	3569	3569	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional and biochemical characterization of B-cell_differentiation_factor -LRB- BCDF -RRB- produced by an HTLV-I-transformed human T-cell clone and demonstration of specific binding of the factor to a BCDF responsive cell line .
3917482	0	BCDF	41,45	B_cell_differentiation_factor	10,39	BCDF	B cell differentiation factor	3569	3569	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of B_cell_differentiation_factor -LRB- BCDF -RRB- on biosynthesis and secretion of immunoglobulin molecules in human B cell lines .
22523498	0	BCHE	92,96	Butyrylcholinesterase	105,126	BCHE	Butyrylcholinesterase	590	590	Gene	Gene	Gene|compound|START_ENTITY Gene|nmod|END_ENTITY	Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase .
11733654	0	BCHE	74,78	butyrylcholinesterase	51,72	BCHE	butyrylcholinesterase	590	590	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of missense mutation -LRB- G365R -RRB- of the butyrylcholinesterase -LRB- BCHE -RRB- gene in a Japanese patient with familial_cholinesterasemia .
15781196	0	BCHE	26,30	butyrylcholinesterase	45,66	BCHE	butyrylcholinesterase	590	590	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Four new mutations in the BCHE gene of human butyrylcholinesterase in a Brazilian blood donor sample .
17700357	0	BCHE	83,87	butyrylcholinesterase	102,123	BCHE	butyrylcholinesterase	590	590	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Expression of three naturally occurring genetic variants -LRB- G75R , E90D , I99M -RRB- of the BCHE gene of human butyrylcholinesterase .
17996334	0	BCHE	95,99	butyrylcholinesterase	72,93	BCHE	butyrylcholinesterase	590	590	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Influence of genetic polymorphisms in the apolipoprotein -LRB- APOE -RRB- and the butyrylcholinesterase -LRB- BCHE -RRB- gene on stress markers in older adults : a 3-year study .
8554068	0	BCHE	74,78	butyrylcholinesterase	51,72	BCHE	butyrylcholinesterase	590	590	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of 12 silent alleles of the human butyrylcholinesterase -LRB- BCHE -RRB- gene .
9252460	0	BCK	13,16	bFGF	0,4	BCK	bFGF	12709(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	bFGF induces BCK promoter-driven expression in muscle via increased binding of a nuclear protein .
12185498	0	BCK2	79,83	PKC1	24,28	BCK2	PKC1	856914(Tax:4932)	852169(Tax:4932)	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2 , a gene involved in cell cycle progression in Saccharomyces_cerevisiae .
1889817	0	BCKDHB	118,124	E1_beta	104,111	BCKDHB	E1 beta	594	594	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regional assignment of two genes of the human branched-chain alpha-keto_acid dehydrogenase complex : the E1_beta gene -LRB- BCKDHB -RRB- to chromosome 6p21-22 and the E2 gene -LRB- DBT -RRB- to chromosome 1p31 .
21212266	0	BCL-2	0,5	ATF5	32,36	BCL-2	ATF5	596	22809	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner .
21212266	0	BCL-2	0,5	ATF5	79,83	BCL-2	ATF5	596	22809	Gene	Gene	target|nsubj|START_ENTITY target|acl:relcl|mediates mediates|dobj|function function|nmod|END_ENTITY	BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner .
25499972	0	BCL-2	0,5	BAD	22,25	BCL-2	BAD	596	572	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	BCL-2 family protein , BAD is down-regulated in breast_cancer and inhibits cell invasion .
9696231	0	BCL-2	40,45	BAK	61,64	BCL-2	BAK	596	578	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	Elevated expression of the proapoptotic BCL-2 family member , BAK , in the human endometrium coincident with apoptosis during the secretory phase of the cycle .
11340567	0	BCL-2	65,70	BAX	71,74	BCL-2	BAX	596	581	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Radiation-induced apoptosis in human myeloma cell line increases BCL-2 / BAX dimer formation and does not result in BAX/BAX homodimerization .
11583631	0	BCL-2	0,5	BAX	63,66	BCL-2	BAX	596	581	Gene	Gene	BCL-X|compound|START_ENTITY sequester|nsubj|BCL-X sequester|dobj|molecules molecules|acl|preventing preventing|dobj|END_ENTITY	BCL-2 , BCL-X -LRB- L -RRB- sequester BH3 domain-only molecules preventing BAX - and BAK-mediated mitochondrial apoptosis .
12421568	0	BCL-2	33,38	BAX	39,42	BCL-2	BAX	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Interleukin-1_beta increases the BCL-2 / BAX ratio in Kaposi 's _ sarcoma cells .
12898509	0	BCL-2	48,53	BAX	76,79	BCL-2	BAX	596	581	Gene	Gene	occurs|nsubj|START_ENTITY occurs|dobj|independent independent|nmod|END_ENTITY	Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK .
16987815	0	BCL-2	24,29	BAX	94,97	BCL-2	BAX	596	581	Gene	Gene	homology|compound|START_ENTITY sufficient|nsubj|homology sufficient|nmod|activation activation|nmod|END_ENTITY	A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro .
17905238	0	BCL-2	18,23	BAX	24,27	BCL-2	BAX	596	581	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|dep|ratio ratio|compound|END_ENTITY	Modulation of the BCL-2 / BAX ratio by interferon-gamma and hypoxia in human peritoneal and adhesion fibroblasts .
18174961	0	BCL-2	50,55	BAX	56,59	BCL-2	BAX	596	581	Gene	Gene	formation|nmod|START_ENTITY formation|dep|END_ENTITY	Enhanced micronucleus formation and modulation of BCL-2 : BAX in MCF-7 cells after exposure to binary mixtures .
18534994	0	BCL-2	93,98	BAX	99,102	BCL-2	BAX	596	581	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	The developing human ovary : immunohistochemical analysis of germ-cell-specific VASA protein , BCL-2 / BAX expression balance and apoptosis .
11920254	0	BCL-2	3,8	BCL-2	37,42	BCL-2	BCL-2	596	596	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	No BCL-2 protein over expression but BCL-2 / IgH rearrangements in B cells of patients with persistent polyclonal B-cell_lymphocytosis .
11920254	0	BCL-2	37,42	BCL-2	3,8	BCL-2	BCL-2	596	596	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	No BCL-2 protein over expression but BCL-2 / IgH rearrangements in B cells of patients with persistent polyclonal B-cell_lymphocytosis .
12893071	0	BCL-2	28,33	BCL-X	8,13	BCL-2	BCL-X	596	598	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Similar BCL-X but different BCL-2 levels in the two age groups of north African nasopharyngeal_carcinomas .
24994123	0	BCL-2	67,72	BCL-XL	80,86	BCL-2	BCL-XL	596	598	Gene	Gene	START_ENTITY|nmod|dependence dependence|amod|END_ENTITY	Maturation stage of T-cell_acute_lymphoblastic_leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199 .
9790773	0	BCL-2	20,25	BID	0,3	BCL-2	BID	12043(Tax:10090)	12122(Tax:10090)	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	BID , a proapoptotic BCL-2 family member , is localized to mouse chromosome 6 and human chromosome 22q11 .
26949185	0	BCL-2	23,28	BOK	0,3	BCL-2	BOK	596	666	Gene	Gene	Effector|compound|START_ENTITY Effector|nsubj|END_ENTITY	BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation .
16600371	0	BCL-2	156,161	Bax	162,165	BCL-2	Bax	596	581	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Stress-induced in vitro apoptosis of native human acute_myelogenous_leukemia -LRB- AML -RRB- cells shows a wide variation between patients and is associated with low BCL-2 : Bax ratio and low levels of heat_shock protein 70 and 90 .
17318810	0	BCL-2	38,43	Bax	46,49	BCL-2	Bax	596	581	Gene	Gene	decreases|xcomp|START_ENTITY decreases|parataxis|ratio ratio|compound|END_ENTITY	Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells .
19439472	0	BCL-2	18,23	Bax	68,71	BCL-2	Bax	596	581	Gene	Gene	homologue|compound|START_ENTITY interacts|nsubj|homologue interacts|nmod|END_ENTITY	The fowlpox_virus BCL-2 homologue , FPV039 , interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis .
20422317	0	BCL-2	80,85	Bax	0,3	BCL-2	Bax	596	581	Gene	Gene	directed|nmod|START_ENTITY treatment|acl|directed remains|nmod|treatment remains|nsubj|expression expression|compound|END_ENTITY	Bax expression remains unchanged following antisense treatment directed against BCL-2 .
9177412	0	BCL-2	45,50	C-MYC	108,113	BCL-2	C-MYC	596	4609	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|expression expression|nmod|END_ENTITY	Expression of the apoptosis-suppressing gene BCL-2 in pheochromocytoma is associated with the expression of C-MYC .
21033101	0	BCL-2	21,26	CD4	28,31	BCL-2	CD4	596	920	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|+ +|compound|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
8826882	0	BCL-2	44,49	CD5	13,16	BCL-2	CD5	596	921	Gene	Gene	family|compound|START_ENTITY expression|nmod|family shifted|nsubjpass|expression shifted|nmod|cells cells|compound|END_ENTITY	In leukaemic CD5 + B cells the expression of BCL-2 gene family is shifted toward protection from apoptosis .
21033101	0	BCL-2	21,26	CD8	34,37	BCL-2	CD8	596	925	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|+ +|compound|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
19439472	0	BCL-2	18,23	FPV039	35,41	BCL-2	FPV039	596	1486587(Tax:10261)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	The fowlpox_virus BCL-2 homologue , FPV039 , interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis .
10555759	0	BCL-2	13,18	IgH	19,22	BCL-2	IgH	596	3492	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Evolution of BCL-2 / IgH hybrid gene RNA expression during treatment of T -LRB- 14 ; 18 -RRB- - bearing follicular_lymphomas .
10828038	0	BCL-2	22,27	IgH	28,31	BCL-2	IgH	596	3492	Gene	Gene	junctions|compound|START_ENTITY junctions|compound|END_ENTITY	Follicular_lymphomas ' BCL-2 / IgH junctions contain templated nucleotide insertions : novel insights into the mechanism of t -LRB- 14 ; 18 -RRB- translocation .
11920254	0	BCL-2	3,8	IgH	43,46	BCL-2	IgH	596	3492	Gene	Gene	protein|compound|START_ENTITY protein|dep|rearrangements rearrangements|compound|END_ENTITY	No BCL-2 protein over expression but BCL-2 / IgH rearrangements in B cells of patients with persistent polyclonal B-cell_lymphocytosis .
11920254	0	BCL-2	37,42	IgH	43,46	BCL-2	IgH	596	3492	Gene	Gene	protein|nmod|START_ENTITY protein|dep|rearrangements rearrangements|compound|END_ENTITY	No BCL-2 protein over expression but BCL-2 / IgH rearrangements in B cells of patients with persistent polyclonal B-cell_lymphocytosis .
16215945	0	BCL-2	1,6	IgH	7,10	BCL-2	IgH	596	3492	Gene	Gene	START_ENTITY|parataxis|translocation translocation|nsubj|END_ENTITY	-LSB- BCL-2 / IgH translocation in peripheral blood cells of healthy Chinese individuals of Han nationality located in Zhejiang area -RSB- .
20368567	0	BCL-2	0,5	IgH	6,9	BCL-2	IgH	596	3492	Gene	Gene	START_ENTITY|appos|predictive predictive|nsubj|status status|amod|END_ENTITY	BCL-2 / IgH polymerase chain reaction status at the end of induction treatment is not predictive for progression-free survival in relapsed/resistant follicular_lymphoma : results of a prospective randomized EORTC 20981 phase III intergroup study .
21518492	0	BCL-2	1,6	IgH	7,10	BCL-2	IgH	596	3492	Gene	Gene	rearrangements|dep|START_ENTITY rearrangements|compound|END_ENTITY	-LSB- BCL-2 / IgH and IgH gene rearrangements in bone marrow mononuclear cells of patients with non-Hodgkin 's _ lymphoma -RSB- .
25048475	0	BCL-2	46,51	LRIG1	0,5	BCL-2	LRIG1	596	26018	Gene	Gene	expression|compound|START_ENTITY modulating|dobj|expression enhances|advcl|modulating enhances|nsubj|END_ENTITY	LRIG1 enhances chemosensitivity by modulating BCL-2 expression and receptor_tyrosine_kinase signaling in glioma cells .
25323917	0	BCL-2	58,63	LRIG1	12,17	BCL-2	LRIG1	596	26018	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	Erratum to `` LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor_Tyrosine_Kinase Signaling in Glioma Cells '' by Guo Z , et al. -LRB- Yonsei Med J 2014 ; 55:1196 -205 . -RRB- .
25449296	0	BCL-2	54,59	LRIG1	0,5	BCL-2	LRIG1	596	26018	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	LRIG1 Improves Chemosensitivity Through Inhibition of BCL-2 and MnSOD in Glioblastoma .
25492572	0	BCL-2	58,63	LRIG1	12,17	BCL-2	LRIG1	596	26018	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	Erratum to `` LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor_Tyrosine_Kinase Signaling in Glioma Cells '' by Guo Z , et al. -LRB- Yonsei Med J 2014 ; 55:1196 -205 . -RRB- .
26722459	0	BCL-2	54,59	MiR-16	0,6	BCL-2	MiR-16	596	51573	Gene	Gene	regulating|dobj|START_ENTITY modulate|advcl|regulating modulate|nsubj|END_ENTITY	MiR-16 modulate temozolomide resistance by regulating BCL-2 in human glioma cells .
23153525	0	BCL-2	25,30	NRAS	20,24	BCL-2	NRAS	596	4893	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	Localization of the NRAS : BCL-2 complex determines anti-apoptotic features associated with progressive_disease in myelodysplastic_syndromes .
10878585	0	BCL-2	91,96	PAR-4	24,29	BCL-2	PAR-4	24224(Tax:10116)	64513(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression involves|dobj|inhibition involves|nsubj|action action|nmod|END_ENTITY	Pro-apoptotic action of PAR-4 involves inhibition of NF-kappaB activity and suppression of BCL-2 expression .
21033101	0	BCL-2	21,26	PCNA	15,19	BCL-2	PCNA	596	5111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
9779488	0	BCL-2	25,30	PCNA	96,100	BCL-2	PCNA	596	5111	Gene	Gene	fraction|amod|START_ENTITY expression|nmod|fraction expression|appos|END_ENTITY	Correlated expression of BCL-2 protein , estrogen_receptor , cathepsin_D and low growth fraction -LRB- PCNA -RRB- in intracystic_papillary_breast_carcinoma .
25338572	0	BCL-2	59,64	TIEG1	12,17	BCL-2	TIEG1	596	7071	Gene	Gene	BAX|compound|START_ENTITY Effects|nmod|BAX Effects|nmod|END_ENTITY	-LSB- Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2 / BAX , PTEN -RSB- .
14769789	0	BCL-2	55,60	TINO	18,22	BCL-2	TINO	596	399664	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of TINO : a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein .
11461089	0	BCL-2	54,59	VEGF	36,40	BCL-2	VEGF	596	7422	Gene	Gene	apoptosis|amod|START_ENTITY upregulates|dobj|apoptosis upregulates|nsubj|Vascular_endothelial_growth_factor Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells .
23160675	0	BCL-2	68,73	VEGF	19,23	BCL-2	VEGF	596	7422	Gene	Gene	activity|compound|START_ENTITY suppression|nmod|activity follows|dobj|suppression follows|nsubj|compensation compensation|nmod|expression expression|compound|END_ENTITY	No compensation in VEGF expression follows antisense suppression of BCL-2 activity .
11461089	0	BCL-2	54,59	Vascular_endothelial_growth_factor	0,34	BCL-2	Vascular endothelial growth factor	596	7422	Gene	Gene	apoptosis|amod|START_ENTITY upregulates|dobj|apoptosis upregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells .
12729577	0	BCL-2	51,56	cytochrome_c	14,26	BCL-2	cytochrome c	596	54205	Gene	Gene	members|compound|START_ENTITY Mechanisms|nmod|members Mechanisms|nmod|release release|amod|END_ENTITY	Mechanisms of cytochrome_c release by proapoptotic BCL-2 family members .
11593425	0	BCL-2	36,41	mTOR	58,62	BCL-2	mTOR	596	21977(Tax:10090)	Gene	Gene	inactivate|dobj|START_ENTITY inactivate|nmod|means means|nmod|kinase kinase|compound|END_ENTITY	Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase .
24163374	0	BCL-2	90,95	mTOR	0,4	BCL-2	mTOR	12043(Tax:10090)	21977(Tax:10090)	Gene	Gene	BCL-XL|compound|START_ENTITY sensitizes|nmod|BCL-XL sensitizes|nsubj|inhibition inhibition|compound|END_ENTITY	mTOR inhibition specifically sensitizes colorectal_cancers with KRAS or BRAF mutations to BCL-2 / BCL-XL inhibition by suppressing MCL-1 .
24870742	0	BCL-2	82,87	microRNA-29c	16,28	BCL-2	microRNA-29c	596	407026	Gene	Gene	regulating|dobj|START_ENTITY induces|advcl|regulating induces|nsubj|END_ENTITY	Exosome-derived microRNA-29c induces apoptosis of BIU-87 cells by down regulating BCL-2 and MCL-1 .
10891529	0	BCL-2	59,64	p53	138,141	BCL-2	p53	596	7157	Gene	Gene	induction|compound|START_ENTITY regulation|nmod|induction synergize|nmod|regulation transformed|nsubj|synergize transformed|nmod|END_ENTITY	Theophylline and cisplatin synergize in down regulation of BCL-2 induction of apoptosis in human granulosa cells transformed by a mutated p53 -LRB- p53 val135 -RRB- and Ha-ras oncogene .
10891529	0	BCL-2	59,64	p53	143,146	BCL-2	p53	596	7157	Gene	Gene	induction|compound|START_ENTITY regulation|nmod|induction synergize|nmod|regulation transformed|nsubj|synergize transformed|nmod|p53 p53|appos|val135 val135|nummod|END_ENTITY	Theophylline and cisplatin synergize in down regulation of BCL-2 induction of apoptosis in human granulosa cells transformed by a mutated p53 -LRB- p53 val135 -RRB- and Ha-ras oncogene .
11407516	0	BCL-2	5,10	p53	0,3	BCL-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	p53 , BCL-2 , and Ki-67 expression according to tumor response after concurrent chemoradiotherapy for advanced rectal_cancer .
16228292	0	BCL-2	0,5	p53	108,111	BCL-2	p53	596	7157	Gene	Gene	antisense|nsubj|START_ENTITY antisense|nmod|END_ENTITY	BCL-2 antisense and cisplatin combination treatment of MCF-7_breast_cancer cells with or without functional p53 .
9779489	0	BCL-2	88,93	p53	83,86	BCL-2	p53	596	7157	Gene	Gene	receptors|dep|START_ENTITY receptors|compound|END_ENTITY	Spontaneous programmed cell death in infiltrating duct_carcinoma : association with p53 , BCL-2 , hormone receptors and tumor proliferation .
14654791	0	BCL-6	46,51	B-cell_lymphoma_gene	22,42	BCL-6	B-cell lymphoma gene	604	12053(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Protein expression of B-cell_lymphoma_gene 6 -LRB- BCL-6 -RRB- in invasive breast_cancer is associated with cyclin_D1 and hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- .
20966935	0	BCL-6	96,101	PRDM1	68,73	BCL-6	PRDM1	604	639	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Follicular dendritic cell-induced microRNA-mediated upregulation of PRDM1 and downregulation of BCL-6 in non-Hodgkin 's B-cell_lymphomas .
15596057	0	BCL-6	13,18	interferon-gamma	38,54	BCL-6	interferon-gamma	604	3458	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of BCL-6 gene expression by interferon-gamma and identification of an IRE in exon I. BCL-6 is a POZ domain zinc-finger transcription factor that appears to play important roles in the development of the immune system and its regulation .
12893071	0	BCL-X	8,13	BCL-2	28,33	BCL-X	BCL-2	598	596	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Similar BCL-X but different BCL-2 levels in the two age groups of north African nasopharyngeal_carcinomas .
11519724	0	BCL-X	34,39	NF-kappaB	48,57	BCL-X	NF-kappaB	24888(Tax:10116)	18033(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain .
24994123	0	BCL-XL	80,86	BCL-2	67,72	BCL-XL	BCL-2	598	596	Gene	Gene	dependence|amod|START_ENTITY END_ENTITY|nmod|dependence	Maturation stage of T-cell_acute_lymphoblastic_leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199 .
21852238	0	BCL-XL	55,61	DJ-1	9,13	BCL-XL	DJ-1	598	11315	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL .
26245900	0	BCL-XL	34,40	KRAS	11,15	BCL-XL	KRAS	598	3845	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism .
26245900	0	BCL-XL	34,40	STAT3	53,58	BCL-XL	STAT3	598	6774	Gene	Gene	Protein|compound|START_ENTITY Protein|nmod|END_ENTITY	The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism .
26422859	0	BCL-xL	86,92	p16	54,57	BCL-xL	p16	598	1029	Gene	Gene	Bax|nummod|START_ENTITY END_ENTITY|appos|Bax	Determination-of apoptosis and cell cycle modulators -LRB- p16 , p21 , p27 , p53 , BCL-2 , Bax , BCL-xL , and cyclin_D1 -RRB- in thyroid_follicular_carcinoma , follicular_adenoma , and adenomatous nodules via a tissue microarray method .
15077128	0	BCL1	33,37	B-cell_leukemia	7,22	BCL1	B-cell leukemia	12443(Tax:10090)	12443(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY cells|compound|END_ENTITY	Murine B-cell_leukemia lymphoma -LRB- BCL1 -RRB- cells as a target for NK cell-mediated immunotherapy .
26118026	0	BCL1	1,5	GLUCOCORTICOID_RECEPTOR	22,45	BCL1	GLUCOCORTICOID RECEPTOR	595	2908	Gene	Gene	POLYMORPHISM|compound|START_ENTITY POLYMORPHISM|nmod|GENE GENE|compound|END_ENTITY	-LSB- BCL1 POLYMORPHISM OF GLUCOCORTICOID_RECEPTOR GENE AND RESPIRATORY DISEASES -RSB- .
2945863	0	BCL1	149,153	IL_2	12,16	BCL1	IL 2	12443(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY clone|nmod|cells secretion|nmod|clone stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Recombinant IL_2 but not recombinant interferon-gamma stimulates both proliferation and IgM secretion in a Ly-1 + clone of neoplastic murine B cells -LRB- BCL1 -RRB- .
3102601	0	BCL1	77,81	IL_2	30,34	BCL1	IL 2	595	3558	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Demonstration of up-regulated IL_2 receptor expression on an in vitro cloned BCL1 subline .
2297794	0	BCL1	67,71	interleukin-5	15,28	BCL1	interleukin-5	12443(Tax:10090)	16191(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Interaction|nmod|cells Interaction|nmod|END_ENTITY	Interaction of interleukin-5 with its receptors on murine leukemic BCL1 cells and its implication in biological activity .
18349075	0	BCL10	31,36	A20	0,3	BCL10	A20	8915	7128	Gene	Gene	activation|amod|START_ENTITY regulator|nmod|activation regulator|nsubj|END_ENTITY	A20 is a negative regulator of BCL10 - and CARMA3-mediated activation of NF-kappaB .
20235165	0	BCL10	51,56	Interleukin-2	0,13	BCL10	Interleukin-2	8915	3558	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer_lymphoma cells .
16341151	0	BCL10	84,89	MALT1	0,5	BCL10	MALT1	8915	10892	Gene	Gene	expression|nmod|START_ENTITY aberrations|nmod|expression aberrations|nsubj|END_ENTITY	MALT1 and BCL10 aberrations in MALT_lymphomas and their effect on the expression of BCL10 in the tumour cells .
18349075	0	BCL10	31,36	NF-kappaB	72,81	BCL10	NF-kappaB	8915	4790	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	A20 is a negative regulator of BCL10 - and CARMA3-mediated activation of NF-kappaB .
19897484	0	BCL10	24,29	NF-kappaB	47,56	BCL10	NF-kappaB	8915	4790	Gene	Gene	lymphoma_10|appos|START_ENTITY required|nsubjpass|lymphoma_10 required|nmod|production production|amod|END_ENTITY	B-cell_CLL / lymphoma_10 -LRB- BCL10 -RRB- is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing_kinase -LRB- NIK -RRB- phosphorylation .
19833888	0	BCL11A	79,85	ADAMTS9	70,77	BCL11A	ADAMTS9	53335	56999	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D , THADA , ADAMTS9 , BCL11A , and MTNR1B affect different aspects of pancreatic beta-cell function .
20676097	0	BCL11A	15,21	KLF1	0,4	BCL11A	KLF1	53335	10661	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	KLF1 regulates BCL11A expression and gamma - to beta-globin gene switching .
19833888	0	BCL11A	79,85	THADA	63,68	BCL11A	THADA	53335	63892	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D , THADA , ADAMTS9 , BCL11A , and MTNR1B affect different aspects of pancreatic beta-cell function .
22675500	0	BCL11A	16,22	TLX	56,59	BCL11A	TLX	53335	4179	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function .
12661009	0	BCL11B	47,53	HOX11L2	14,21	BCL11B	HOX11L2	64919	30012	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of HOX11L2 by juxtaposition with 3 ' - BCL11B in an acute_lymphoblastic_leukemia cell line -LRB- HPB-ALL -RRB- with t -LRB- 5 ; 14 -RRB- -LRB- q35 ; q32 .2 -RRB- .
20647330	0	BCL2	34,38	BAD	0,3	BCL2	BAD	596	572	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	BAD , a proapoptotic member of the BCL2 family , is a potential therapeutic target in hepatocellular_carcinoma .
10778970	0	BCL2	51,55	BAX	0,3	BCL2	BAX	596	581	Gene	Gene	expression|nummod|START_ENTITY impact|nmod|expression modulate|dobj|impact modulate|nsubj|END_ENTITY	BAX and PKCalpha modulate the prognostic impact of BCL2 expression in acute_myelogenous_leukemia .
18818203	0	BCL2	15,19	BAX	40,43	BCL2	BAX	596	581	Gene	Gene	function|nmod|START_ENTITY requires|nsubj|function requires|dobj|END_ENTITY	G0 function of BCL2 and BCL-xL requires BAX , BAK , and p27 phosphorylation by Mirk , revealing a novel role of BAX_and_BAK in quiescence regulation .
9682022	0	BCL2	17,21	BAX	36,39	BCL2	BAX	596	581	Gene	Gene	member|compound|START_ENTITY Placement|nmod|member END_ENTITY|nsubj|Placement	Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation .
19549844	0	BCL2	20,24	BCL6	0,4	BCL2	BCL6	596	604	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse_large_B_cell_lymphoma .
16006797	0	BCL2	140,144	MIB1	134,138	BCL2	MIB1	596	57534	Gene	Gene	neu|dep|START_ENTITY neu|dep|END_ENTITY	An immunohistochemical comparison between low-grade and high-grade ovarian_serous_carcinomas : significantly higher expression of p53 , MIB1 , BCL2 , HER-2 / neu , and C-KIT in high-grade neoplasms .
23317270	0	BCL2	57,61	RHOXF1	15,21	BCL2	RHOXF1	596	158800	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	shRNA mediated RHOXF1 silencing influences expression of BCL2 but not CASP8 in MCF-7 and MDA-MB-231 cell lines .
20457620	0	BCL2	116,120	STAT1	73,78	BCL2	STAT1	596	6772	Gene	Gene	members|amod|START_ENTITY members|nummod|END_ENTITY	IFNgamma restores_breast_cancer sensitivity to fulvestrant by regulating STAT1 , IFN_regulatory_factor_1 , NF-kappaB , BCL2 family members , and signaling to caspase-dependent apoptosis .
25014217	0	BCL2	35,39	ZFP36L1	72,79	BCL2	ZFP36L1	596	677	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells .
16469847	0	BCL2	45,49	gata4	21,26	BCL2	gata4	12043(Tax:10090)	14463(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo .
16194898	0	BCL2	17,21	immunoglobulin_heavy_chain	43,69	BCL2	immunoglobulin heavy chain	596	3495	Gene	Gene	Translocation|nmod|START_ENTITY Translocation|nmod|END_ENTITY	Translocation of BCL2 and BCL6 to the same immunoglobulin_heavy_chain locus in a case of follicular_lymphoma .
16006797	0	BCL2	140,144	p53	129,132	BCL2	p53	596	7157	Gene	Gene	neu|dep|START_ENTITY neu|compound|END_ENTITY	An immunohistochemical comparison between low-grade and high-grade ovarian_serous_carcinomas : significantly higher expression of p53 , MIB1 , BCL2 , HER-2 / neu , and C-KIT in high-grade neoplasms .
24867259	0	BCL2A1	17,23	ELK1	49,53	BCL2A1	ELK1	597	2002	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|advcl|activating activating|dobj|END_ENTITY	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1 / 2 pathway .
22098591	0	BCL2L1	47,53	Mitochondrial_transcription_factor_A	0,36	BCL2L1	Mitochondrial transcription factor A	598	7019	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Mitochondrial_transcription_factor_A regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian_cancer .
19376117	0	BCL2L12	15,22	HSP70	0,5	BCL2L12	HSP70	83596	3308	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation .
26506896	0	BCL2L13	0,7	Atg32	63,68	BCL2L13	Atg32	23786	854660(Tax:4932)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32 .
16732314	0	BCL3	0,4	IL-6	19,23	BCL3	IL-6	602	3569	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription .
12456498	0	BCL3	25,29	p23	52,55	BCL3	p23	602	10728	Gene	Gene	t|compound|START_ENTITY t|dep|END_ENTITY	High-level expression of BCL3 differentiates t -LRB- 2 ; 5 -RRB- -LRB- p23 ; q35 -RRB- - positive anaplastic_large_cell_lymphoma from Hodgkin_disease .
23166356	0	BCL6	0,4	AID	26,29	BCL6	AID	604	57379	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	BCL6 positively regulates AID and germinal center gene expression via repression of miR-155 .
23476051	0	BCL6	0,4	AID	31,34	BCL6	AID	604	57379	Gene	Gene	breaks|compound|START_ENTITY occur|nsubj|breaks occur|nmod|motifs motifs|compound|END_ENTITY	BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements .
19549844	0	BCL6	0,4	BCL2	20,24	BCL6	BCL2	604	596	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse_large_B_cell_lymphoma .
24793055	0	BCL6	65,69	BTB	70,73	BCL6	BTB	604	604	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Molecular dynamics analysis of the interaction between the human BCL6 BTB domain and its SMRT , NcoR and BCOR corepressors : the quest for a consensus dynamic pharmacophore .
21808017	0	BCL6	32,36	CD4	49,52	BCL6	CD4	604	920	Gene	Gene	B-cell_lymphoma_6|appos|START_ENTITY B-cell_lymphoma_6|dep|subset subset|compound|END_ENTITY	Human tonsil B-cell_lymphoma_6 -LRB- BCL6 -RRB- - expressing CD4 + T-cell subset specialized for B-cell help outside germinal centers .
24362533	0	BCL6	42,46	CTCF	6,10	BCL6	CTCF	604	10664	Gene	Gene	exon1A|nmod|START_ENTITY site|nmod|exon1A binding|nmod|site binding|compound|END_ENTITY	Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus .
26682243	0	BCL6	40,44	CTCF	25,29	BCL6	CTCF	604	10664	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The epigenetic regulator CTCF modulates BCL6 in lymphoma .
22113614	0	BCL6	15,19	FBXO11	0,6	BCL6	FBXO11	604	80204	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	FBXO11 targets BCL6 for degradation and is inactivated in diffuse_large_B-cell_lymphomas .
22580161	0	BCL6	15,19	Ken	28,31	BCL6	Ken	604	37785(Tax:7227)	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche .
23795761	0	BCL6	9,13	LITAF	0,5	BCL6	LITAF	604	9516	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	LITAF , a BCL6 target gene , regulates autophagy in mature B-cell_lymphomas .
25297597	0	BCL6	17,21	MYC	23,26	BCL6	MYC	604	4609	Gene	Gene	abnormalities|compound|START_ENTITY abnormalities|appos|END_ENTITY	-LSB- Significance of BCL6 , MYC , P53 genes abnormalities for the prognosis of diffuse_large_B-cell_lymphoma -RSB- .
16142238	0	BCL6	0,4	Miz-1	45,50	BCL6	Miz-1	604	7709	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells .
19549844	0	BCL6	0,4	Miz1	29,33	BCL6	Miz1	604	9063	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse_large_B_cell_lymphoma .
25297597	0	BCL6	17,21	P53	28,31	BCL6	P53	604	7157	Gene	Gene	abnormalities|compound|START_ENTITY abnormalities|appos|END_ENTITY	-LSB- Significance of BCL6 , MYC , P53 genes abnormalities for the prognosis of diffuse_large_B-cell_lymphoma -RSB- .
17468402	0	BCL6	32,36	PDCD2	18,23	BCL6	PDCD2	604	5134	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas .
27066093	0	BCL6	19,23	Prolactin	0,9	BCL6	Prolactin	604	5617	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Prolactin Inhibits BCL6 Expression in Breast_Cancer Cells through a MicroRNA-339-5p-Dependent Pathway .
25176650	0	BCL6	4,8	RD2	9,12	BCL6	RD2	12053(Tax:10090)	19133(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers .
15860730	0	BCL6	0,4	RhoA	16,20	BCL6	RhoA	604	387	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	BCL6 suppresses RhoA activity to alter macrophage morphology and motility .
16819511	0	BCL6	16,20	STAT5	0,5	BCL6	STAT5	604	6776	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas .
24282530	0	BCL6	65,69	miR-127	0,7	BCL6	miR-127	604	406914	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-127 regulates cell proliferation and senescence by targeting BCL6 .
15577913	0	BCL6	4,8	p53	35,38	BCL6	p53	604	7157	Gene	Gene	proto-oncogene|compound|START_ENTITY suppresses|nsubj|proto-oncogene suppresses|dobj|expression expression|compound|END_ENTITY	The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells .
16249378	0	BCL6	0,4	p53	21,24	BCL6	p53	604	7157	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	BCL6 is regulated by p53 through a response element frequently disrupted in B-cell_non-Hodgkin_lymphoma .
19405121	0	BCL6	0,4	p53	50,53	BCL6	p53	12053(Tax:10090)	22060(Tax:10090)	Gene	Gene	cooperates|nummod|START_ENTITY cooperates|nmod|stimulation stimulation|nmod|END_ENTITY	BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells .
26998113	0	BCL9	0,4	miR-30c	68,75	BCL9	miR-30c	607	407031	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|advcl|END_ENTITY	BCL9 , a coactivator for Wnt/b-catenin transcription , is targeted by miR-30c and is associated with prostate_cancer progression .
26676636	0	BCLAF1	67,73	SMYD3	12,17	BCLAF1	SMYD3	9774	64754	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Upregulated SMYD3 promotes bladder_cancer progression by targeting BCLAF1 and activating autophagy .
23071284	0	BCMA	17,21	APRIL	0,5	BCMA	APRIL	608	8741	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells .
24376672	0	BCMA	20,24	APRIL	6,11	BCMA	APRIL	608	8741	Gene	Gene	TACI|appos|START_ENTITY TACI|appos|END_ENTITY	BAFF , APRIL , TWEAK , BCMA , TACI and Fn14 proteins are related to human glioma_tumor grade : immunohistochemistry and public microarray data meta-analysis .
22166983	0	BCMA	27,31	B-cell_maturation_antigen	0,25	BCMA	B-cell maturation antigen	608	608	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	B-cell_maturation_antigen -LRB- BCMA -RRB- activation exerts specific proinflammatory effects in normal human keratinocytes and is preferentially expressed in inflammatory skin pathologies .
15944757	0	BCMA	123,127	BLyS	94,98	BCMA	BLyS	21935(Tax:10090)	24099(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Generation and characterization of C305 , a murine neutralizing scFv antibody that can inhibit BLyS binding to its receptor BCMA .
23242501	0	BCMA	101,105	B_lymphocyte_stimulator	13,36	BCMA	B lymphocyte stimulator	608	10673	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	An optimized B_lymphocyte_stimulator -LRB- BLyS -RRB- antagonist peptide inhibits the interaction of BLyS with BCMA .
24376672	0	BCMA	20,24	TWEAK	13,18	BCMA	TWEAK	608	8742	Gene	Gene	TACI|appos|START_ENTITY TACI|appos|END_ENTITY	BAFF , APRIL , TWEAK , BCMA , TACI and Fn14 proteins are related to human glioma_tumor grade : immunohistochemistry and public microarray data meta-analysis .
20122251	0	BCO2	54,58	beta-carotene_oxygenase_2	27,52	BCO2	beta-carotene oxygenase 2	100286796(Tax:9940)	100286796(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A nonsense mutation in the beta-carotene_oxygenase_2 -LRB- BCO2 -RRB- gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep -LRB- Ovis_aries -RRB- .
25331958	0	BCOR	94,98	Interferon_regulatory_factor_8	0,30	BCOR	Interferon regulatory factor 8	71458(Tax:10090)	15900(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Interferon_regulatory_factor_8 -LRB- IRF8 -RRB- interacts with the B_cell_lymphoma 6 -LRB- BCL6 -RRB- corepressor BCOR .
23523425	0	BCOR	62,66	PCGF1	40,45	BCOR	PCGF1	54880	84759	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs .
1842923	0	BCP_54	78,84	ALDH_3	85,91	BCP 54	ALDH 3	281617(Tax:9913)	281617(Tax:9913)	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Degenerate oligonucleotide sequence-directed cross-species PCR cloning of the BCP_54 / ALDH_3 cDNA : priming from inverted repeats and formation of tandem primer arrays .
8109457	0	BCP_54	45,51	bovine_corneal_protein_54K	17,43	BCP 54	bovine corneal protein 54K	281617(Tax:9913)	281617(Tax:9913)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	-LSB- Localization of bovine_corneal_protein_54K -LRB- BCP_54 -RRB- in the prenatal mouse eye -RSB- .
10526530	0	BCR	28,31	ABL	43,46	BCR	ABL	613	25	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Insertion of the 5 ' part of BCR within the ABL gene at 9q34 in a Philadelphia-negative chronic_myeloid_leukemia .
11502748	0	BCR	27,30	Dbl	4,7	BCR	Dbl	110279(Tax:10090)	109904(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome .
22767509	0	BCR	40,43	Rac1	44,48	BCR	Rac1	110279(Tax:10090)	19353(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein , a substrate of PTPRT .
21674065	0	BCR	44,47	TLR-2	31,36	BCR	TLR-2	613	7097	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting_B cells .
22778153	0	BCR-ABL	10,17	ABCG2	124,129	BCR-ABL	ABCG2	25	9429	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2 .
18936234	0	BCR-ABL	21,28	AHI-1	0,5	BCR-ABL	AHI-1	25	54806	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells .
26118501	0	BCR-ABL	41,48	BAP1	22,26	BCR-ABL	BAP1	25	8314	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	The downregulation of BAP1 expression by BCR-ABL reduces the stability of BRCA1 in chronic_myeloid_leukemia .
9096220	0	BCR-ABL	39,46	Bcl-2	14,19	BCR-ABL	Bcl-2	25	596	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras .
11753385	0	BCR-ABL	0,7	C/EBPalpha	19,29	BCR-ABL	C/EBPalpha	25	1050	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP_E2 .
9195915	0	BCR-ABL	25,32	CBL	16,19	BCR-ABL	CBL	25	867	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells .
21638198	0	BCR-ABL	34,41	CCN3	73,77	BCR-ABL	CCN3	25	4856	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML .
15345592	0	BCR-ABL	13,20	CD34	41,45	BCR-ABL	CD34	25	947	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Detection of BCR-ABL kinase mutations in CD34 + cells from chronic_myelogenous_leukemia patients in complete cytogenetic remission on imatinib_mesylate treatment .
16932347	0	BCR-ABL	0,7	CD8	65,68	BCR-ABL	CD8	25	925	Gene	Gene	regions|amod|START_ENTITY regions|nmod|source source|nmod|T-cell T-cell|compound|END_ENTITY	BCR-ABL fusion regions as a source of multiple_leukemia-specific CD8 + T-cell epitopes .
9747873	0	BCR-ABL	56,63	GRB10	35,40	BCR-ABL	GRB10	25	14783(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The SH2-containing adapter protein GRB10 interacts with BCR-ABL .
25127392	0	BCR-ABL	44,51	MK-0457	19,26	BCR-ABL	MK-0457	25	1477760(Tax:190192)	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic_myelogenous_leukemia and philadelphia_chromosome-positive_acute_lymphoblastic_leukemia .
15993098	0	BCR-ABL	30,37	Osteopontin	0,11	BCR-ABL	Osteopontin	25	6696	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Osteopontin is upregulated by BCR-ABL .
15833859	0	BCR-ABL	0,7	PI3K	51,55	BCR-ABL	PI3K	25	5293	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic_myelogenous_leukemia cells .
25608112	0	BCR-ABL	0,7	PTEN	30,34	BCR-ABL	PTEN	25	5728	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation .
12821944	0	BCR-ABL	49,56	STAT3	40,45	BCR-ABL	STAT3	25	6774	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells .
15833859	0	BCR-ABL	0,7	Skp2	34,38	BCR-ABL	Skp2	25	6502	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic_myelogenous_leukemia cells .
25450971	0	BCR-ABL	66,73	Zyxin	57,62	BCR-ABL	Zyxin	25	7791	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells .
14562121	0	BCR-ABL	69,76	fibroblast_growth_factor_receptor_3	24,59	BCR-ABL	fibroblast growth factor receptor 3	25	2261	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Increased expression of fibroblast_growth_factor_receptor_3 in CD34 + BCR-ABL + cells from patients with chronic_myeloid_leukemia .
22151181	0	BCR-ABL	23,30	hTERT	14,19	BCR-ABL	hTERT	25	7015	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hTERT by BCR-ABL at multiple levels in K562 cells .
8251915	0	BCR-ABL	37,44	myc	12,15	BCR-ABL	myc	25	4609	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of myc in transformation by BCR-ABL .
10602422	0	BCR-ABL	68,75	p190	62,66	BCR-ABL	p190	25	8506	Gene	Gene	START_ENTITY|nsubj|acute_lymphoblastic_leukemia acute_lymphoblastic_leukemia|nmod|b3a2 b3a2|appos|END_ENTITY	Pre-B acute_lymphoblastic_leukemia with b3a2 -LRB- p210 -RRB- and e1a2 -LRB- p190 -RRB- BCR-ABL fusion transcripts relapsing as chronic_myelogenous_leukemia with a less differentiated b3a2 -LRB- p210 -RRB- clone .
10753848	0	BCR-ABL	242,249	p190	237,241	BCR-ABL	p190	25	8506	Gene	Gene	detection|appos|START_ENTITY detection|amod|END_ENTITY	Molecular analysis of lineage-specific chimerism and minimal_residual_disease by RT-PCR of p210 -LRB- BCR-ABL -RRB- and p190 -LRB- BCR-ABL -RRB- after allogeneic bone marrow transplantation for chronic_myeloid_leukemia : increasing mixed myeloid chimerism and p190 -LRB- BCR-ABL -RRB- detection precede cytogenetic relapse .
19091403	0	BCR-ABL	64,71	p190	59,63	BCR-ABL	p190	25	8506	Gene	Gene	START_ENTITY|nsubj|response response|nmod|imatinib imatinib|nmod|END_ENTITY	Molecular response to imatinib in patient with Ph negative p190 BCR-ABL transcript positive chronic_myeloid_leukemia with cyclic_leukocytosis .
25949834	0	BCR-ABL	45,52	p190	39,43	BCR-ABL	p190	25	8506	Gene	Gene	Methods|appos|START_ENTITY Methods|nmod|END_ENTITY	Optimal Molecular Methods in Detecting p190 -LRB- BCR-ABL -RRB- Fusion Variants in Hematologic_Malignancies : A Case Report and Review of the Literature .
9310467	0	BCR-ABL	2,9	p190	10,14	BCR-ABL	p190	25	19417(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A BCR-ABL -LRB- p190 -RRB- fusion gene made by homologous recombination causes B-cell_acute_lymphoblastic_leukemias in chimeric mice with independence of the endogenous bcr product .
10602422	0	BCR-ABL	68,75	p210	170,174	BCR-ABL	p210	25	2125	Gene	Gene	START_ENTITY|dobj|transcripts transcripts|acl|relapsing relapsing|nmod|clone clone|appos|END_ENTITY	Pre-B acute_lymphoblastic_leukemia with b3a2 -LRB- p210 -RRB- and e1a2 -LRB- p190 -RRB- BCR-ABL fusion transcripts relapsing as chronic_myelogenous_leukemia with a less differentiated b3a2 -LRB- p210 -RRB- clone .
10602422	0	BCR-ABL	68,75	p210	46,50	BCR-ABL	p210	25	2125	Gene	Gene	START_ENTITY|nsubj|acute_lymphoblastic_leukemia acute_lymphoblastic_leukemia|nmod|b3a2 b3a2|appos|END_ENTITY	Pre-B acute_lymphoblastic_leukemia with b3a2 -LRB- p210 -RRB- and e1a2 -LRB- p190 -RRB- BCR-ABL fusion transcripts relapsing as chronic_myelogenous_leukemia with a less differentiated b3a2 -LRB- p210 -RRB- clone .
11964283	0	BCR-ABL	19,26	p210	14,18	BCR-ABL	p210	25	2125	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Modulation of p210 -LRB- BCR-ABL -RRB- activity in transduced primary human hematopoietic cells controls lineage programming .
12036931	0	BCR-ABL	25,32	p210	20,24	BCR-ABL	p210	25	2125	Gene	Gene	fusion|appos|START_ENTITY fusion|amod|END_ENTITY	Immunogenicity of a p210 -LRB- BCR-ABL -RRB- fusion domain candidate DNA vaccine targeted to dendritic cells by a recombinant adeno-associated virus vector in vitro .
14564482	0	BCR-ABL	76,83	p210	71,75	BCR-ABL	p210	25	2125	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Identification of new MHC-restriction elements for presentation of the p210 -LRB- BCR-ABL -RRB- fusion region to human cytotoxic T lymphocytes .
15458517	0	BCR-ABL	111,118	p210	120,124	BCR-ABL	p210	25	2125	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Acquired amegakaryocytic_thrombocytopenia associated with proliferation of gamma/delta TCR T-lymphocytes and a BCR-ABL -LRB- p210 -RRB- fusion transcript .
17315025	0	BCR-ABL	5,12	p210	0,4	BCR-ABL	p210	25	2125	Gene	Gene	reprograms|appos|START_ENTITY reprograms|amod|END_ENTITY	p210 -LRB- BCR-ABL -RRB- reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription .
18059481	0	BCR-ABL	33,40	p210	28,32	BCR-ABL	p210	25	2125	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Subcellular distribution of p210 -LRB- BCR-ABL -RRB- in CML cell lines and primary CD34 + CML cells .
9593785	0	BCR-ABL	52,59	p210	47,51	BCR-ABL	p210	25	2125	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic_myelogenous_leukemia .
10419904	0	BCR-Abl	20,27	STAT5	0,5	BCR-Abl	STAT5	25	6776	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells .
11010972	0	BCR/ABL	0,7	AKT	120,123	BCR/ABL	AKT	25	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol_3-Kinase / AKT pathway .
14724585	0	BCR/ABL	96,103	AML1	5,9	BCR/ABL	AML1	110279;11350	12394(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Both AML1 and EVI1 oncogenic components are required for the cooperation of AML1/MDS1/EVI1 with BCR/ABL in the induction of acute_myelogenous_leukemia in mice .
11857085	0	BCR/ABL	58,65	CBL	41,44	BCR/ABL	CBL	110279;11350	12402(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells .
8810278	0	BCR/ABL	106,113	CRKL	59,63	BCR/ABL	CRKL	25;613	1399	Gene	Gene	oncogene|compound|START_ENTITY transformed|nmod|oncogene cells|acl|transformed forms|nmod|cells forms|dobj|complex complex|nmod|END_ENTITY	p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene .
9053848	0	BCR/ABL	28,35	CRKL	16,20	BCR/ABL	CRKL	110279(Tax:10090)	12929(Tax:10090)	Gene	Gene	site|amod|START_ENTITY site|nsubj|Tyrosine Tyrosine|nmod|END_ENTITY	Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site .
9067577	0	BCR/ABL	4,11	CRKL	64,68	BCR/ABL	CRKL	25	1399	Gene	Gene	oncogene|compound|START_ENTITY alters|nsubj|oncogene alters|dobj|interaction interaction|nmod|END_ENTITY	The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins .
11245441	0	BCR/ABL	32,39	Crkl	0,4	BCR/ABL	Crkl	25	12929(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY leukemogenesis|nmod|transgenic_mice enhances|dobj|leukemogenesis enhances|nsubj|END_ENTITY	Crkl enhances leukemogenesis in BCR/ABL P190 transgenic_mice .
27070757	0	BCR/ABL	0,7	EZH2	18,22	BCR/ABL	EZH2	110279(Tax:10090)	14056(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nummod|END_ENTITY	BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic_myeloid_leukemia cells .
12124177	0	BCR/ABL	44,51	Gab2	18,22	BCR/ABL	Gab2	110279;11350	14389(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role for Gab2 in transformation by BCR/ABL .
11222392	0	BCR/ABL	169,176	Interleukin_3	0,13	BCR/ABL	Interleukin 3	110279;11350	16187(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Interleukin_3 and granulocyte-macrophage_colony-stimulating_factor are not required for induction of chronic_myeloid_leukemia-like_myeloproliferative_disease in mice by BCR/ABL .
18193087	0	BCR/ABL	43,50	Notch1	77,83	BCR/ABL	Notch1	110279;11350	18128(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute_leukemia in p210BCR/ABL transgenic_mice .
18997174	0	BCR/ABL	48,55	PTPROt	0,6	BCR/ABL	PTPROt	25;613	5800	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells .
15596148	0	BCR/ABL	0,7	Rap1	18,22	BCR/ABL	Rap1	110279(Tax:10090)	109905(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells .
10523635	0	BCR/ABL	0,7	SHIP	40,44	BCR/ABL	SHIP	25	16331(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	BCR/ABL directly inhibits expression of SHIP , an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis .
11593388	0	BCR/ABL	64,71	STAT5	37,42	BCR/ABL	STAT5	25;613	6776	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells .
12411494	0	BCR/ABL	34,41	STAT5	45,50	BCR/ABL	STAT5	25;613	6776	Gene	Gene	START_ENTITY|nmod|activation activation|nummod|END_ENTITY	The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid_leukemia cells .
21123451	0	BCR/ABL	0,7	WRN	19,22	BCR/ABL	WRN	25	7486	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	BCR/ABL stimulates WRN to promote survival and genomic instability .
16849647	0	BCR/ABL	28,35	histidine_decarboxylase	58,81	BCR/ABL	histidine decarboxylase	110279;11350	15186(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The CML-related oncoprotein BCR/ABL induces expression of histidine_decarboxylase -LRB- HDC -RRB- and the synthesis of histamine in leukemic cells .
7606740	0	BCR/ABL	120,127	p230	115,119	BCR/ABL	p230	25	2803	Gene	Gene	protein|amod|START_ENTITY protein|nummod|END_ENTITY	Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein .
11010972	0	BCR/ABL	0,7	p27Kip1	70,77	BCR/ABL	p27Kip1	25	1027	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol_3-Kinase / AKT pathway .
12393646	0	BCR/ABL	0,7	vascular_endothelial_growth_factor	30,64	BCR/ABL	vascular endothelial growth factor	25	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	BCR/ABL induces expression of vascular_endothelial_growth_factor and its transcriptional activator , hypoxia inducible factor-1alpha , through a pathway involving phosphoinositide 3-kinase and the mammalian_target_of_rapamycin .
1334711	0	BCRF1	19,24	interleukin_10	45,59	BCRF1	interleukin 10	3783690(Tax:10376)	3586	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Epstein-Barr_virus BCRF1 gene product -LRB- viral interleukin_10 -RRB- inhibits superoxide anion production by human monocytes .
12694888	0	BCRP	70,74	ABCG2	63,68	BCRP	ABCG2	9429	9429	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic variation in the ATP-binding_cassette_transporter gene ABCG2 -LRB- BCRP -RRB- in a Swedish population .
15475413	0	BCRP	32,36	ABCG2	25,30	BCRP	ABCG2	9429	9429	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Functional assessment of ABCG2 -LRB- BCRP -RRB- gene polymorphisms to protein expression in human placenta .
15955871	0	BCRP	15,19	ABCG2	21,26	BCRP	ABCG2	9429	9429	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of BCRP -LRB- ABCG2 -RRB- in the biliary excretion of pitavastatin .
18623116	0	BCRP	27,31	ABCG2	33,38	BCRP	ABCG2	9429	9429	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Folate deprivation induces BCRP -LRB- ABCG2 -RRB- expression and mitoxantrone resistance in Caco-2 cells .
20682644	0	BCRP	21,25	ABCG2	14,19	BCRP	ABCG2	9429	9429	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ABCG2 -LRB- BCRP -RRB- is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype .
22354538	0	BCRP	76,80	ABCG2	37,42	BCRP	ABCG2	478472(Tax:9615)	478472(Tax:9615)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway .
25028581	0	BCRP	21,25	ABCG2	14,19	BCRP	ABCG2	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ABCG2 -LRB- BCRP -RRB- in mouse models with enhanced erythropoiesis .
25479544	0	BCRP	27,31	EGFR	4,8	BCRP	EGFR	9429	1956	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	The EGFR Pathway Regulates BCRP Expression in NSCLC Cells : Role of Erlotinib .
26703673	0	BCRP	60,64	MRP2	43,47	BCRP	MRP2	9429	1244	Gene	Gene	ABCC2|appos|START_ENTITY ABCC2|appos|END_ENTITY	Genistein and Glyceollin Effects on ABCC2 -LRB- MRP2 -RRB- and ABCG2 -LRB- BCRP -RRB- in Caco-2 Cells .
25522789	0	BCRP	98,102	P-Glycoprotein	38,52	BCRP	P-Glycoprotein	644079	5243	Gene	Gene	START_ENTITY|nsubj|Knockout Knockout|nmod|END_ENTITY	Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type , Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases .
25522789	0	BCRP	98,102	P-Glycoprotein	73,87	BCRP	P-Glycoprotein	644079	5243	Gene	Gene	START_ENTITY|nsubj|Knockout Knockout|nmod|P-Glycoprotein P-Glycoprotein|nmod|END_ENTITY	Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type , Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases .
22115371	0	BCRP	65,69	P-glycoprotein	12,26	BCRP	P-glycoprotein	9429	5243	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of P-glycoprotein and breast_cancer_resistance_protein -LRB- BCRP -RRB- in bacterial attachment to human gastrointestinal cells .
24295377	0	BCRP	86,90	P-glycoprotein	59,73	BCRP	P-glycoprotein	9429	5243	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Tivozanib reverses multidrug resistance mediated by ABCB1 -LRB- P-glycoprotein -RRB- and ABCG2 -LRB- BCRP -RRB- .
11986234	0	BCRP	61,65	breast_cancer_resistance_protein	27,59	BCRP	breast cancer resistance protein	9429	9429	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and activity of breast_cancer_resistance_protein -LRB- BCRP -RRB- in de novo and relapsed acute_myeloid_leukemia .
14645676	0	BCRP	71,75	breast_cancer_resistance_protein	37,69	BCRP	breast cancer resistance protein	9429	9429	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of human breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- expressed in the oocytes of Xenopus_laevis .
14989769	0	BCRP	101,105	breast_cancer_resistance_protein	67,99	BCRP	breast cancer resistance protein	9429	9429	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Relationship between resistance to chemotherapy and expression of breast_cancer_resistance_protein -LRB- BCRP -RRB- gene in patients with acute_leukemia -RSB- .
15946326	0	BCRP	50,54	breast_cancer_resistance_protein	16,48	BCRP	breast cancer resistance protein	9429	9429	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of breast_cancer_resistance_protein -LRB- BCRP -RRB- in microvessel endothelium of human control and epileptic brain .
18255023	0	BCRP	65,69	breast_cancer_resistance_protein	31,63	BCRP	breast cancer resistance protein	9429	9429	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localisation of breast_cancer_resistance_protein -LRB- BCRP -RRB- in human fetal membranes and decidua and the influence of labour at term .
23402418	0	BCRP	59,63	breast_cancer_resistance_protein	25,57	BCRP	breast cancer resistance protein	9429	9429	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Revolving door action of breast_cancer_resistance_protein -LRB- BCRP -RRB- facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells .
25502234	0	BCRP	42,46	breast_cancer_resistance_protein	8,40	BCRP	breast cancer resistance protein	9429	9429	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of breast_cancer_resistance_protein -LRB- BCRP -RRB- as active efflux transporter on blood-brain barrier -LRB- BBB -RRB- permeability .
17350607	0	BChE	40,44	butyrylcholinesterase	17,38	BChE	butyrylcholinesterase	590	590	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of butyrylcholinesterase -LRB- BChE -RRB- phenotypes to predict the risk of prolonged apnea in persons receiving succinylcholine in the healthy population of western Iran .
24396420	0	BD1047	11,17	mTOR	67,71	BD1047	mTOR	2734415(Tax:264462)	21977(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of BD1047 , a 1 receptor antagonist , on the expression of mTOR , Camk2y and GSK-3b in fluvoxamine-treated N2a cells .
16698686	0	BDCA-1	25,31	CD11c	14,19	BDCA-1	CD11c	911	3687	Gene	Gene	DC|compound|START_ENTITY DC|amod|END_ENTITY	CD34 + - derived CD11c + _ + + BDCA-1 + + CD123 + + DC : expansion of a phenotypically undescribed myeloid DC1 population for use in adoptive immunotherapy .
17786242	0	BDCA-1	59,65	CD11c	53,58	BDCA-1	CD11c	911	3687	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Normal human dermis contains distinct populations of CD11c + BDCA-1 + dendritic cells and CD163 + FXIIIA + macrophages .
23901045	0	BDCA-1	71,77	CD1c	64,68	BDCA-1	CD1c	911	911	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Novel function for the p38-MK2 signaling pathway in circulating CD1c + -LRB- BDCA-1 + -RRB- myeloid dendritic cells from healthy donors and advanced cancer patients ; inhibition of p38 enhances IL-12 whilst suppressing IL-10 .
20479116	0	BDCA-3	14,20	CD141	6,11	BDCA-3	CD141	7056	7056	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Human CD141 + -LRB- BDCA-3 -RRB- + dendritic cells -LRB- DCs -RRB- represent a unique myeloid DC subset that cross-presents necrotic cell antigens .
21264308	0	BDCA2	49,54	CD123	42,47	BDCA2	CD123	170482	3563	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|compound|END_ENTITY	Expression of the T cell receptor ab on a CD123 + BDCA2 + HLA-DR + subpopulation in head and neck_squamous_cell_carcinoma .
22234694	0	BDCA3	98,103	CLEC9A	27,33	BDCA3	CLEC9A	7056	283420	Gene	Gene	cells|compound|START_ENTITY mediates|nmod|cells mediates|nsubj|END_ENTITY	The C-type_lectin_receptor CLEC9A mediates antigen uptake and -LRB- cross - -RRB- presentation by human blood BDCA3 + myeloid dendritic cells .
20479117	0	BDCA3	34,39	DNGR-1	26,32	BDCA3	DNGR-1	7056	283420	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of human DNGR-1 + BDCA3 + leukocytes as putative equivalents of mouse CD8alpha + dendritic cells .
15705059	0	BDKRB1	87,93	bradykinin_B1_receptor	63,85	BDKRB1	bradykinin B1 receptor	623	623	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	In vivo DNase I-mediated footprinting analysis along the human bradykinin_B1_receptor -LRB- BDKRB1 -RRB- gene promoter : evidence for cell-specific regulation .
15262269	0	BDNF	74,78	APP	127,130	BDNF	APP	12064(Tax:10090)	351	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1 .
25041363	0	BDNF	67,71	Activation-induced_cytidine_deaminase	0,37	BDNF	Activation-induced cytidine deaminase	627	57379	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Activation-induced_cytidine_deaminase regulates activity-dependent BDNF expression in post-mitotic cortical neurons .
26111610	0	BDNF	0,4	BDNF	87,91	BDNF	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|dep|signaling signaling|compound|END_ENTITY	BDNF signaling in the rat cerebello-vestibular pathway during vestibular compensation : BDNF signaling in vestibular compensation .
26111610	0	BDNF	87,91	BDNF	0,4	BDNF	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|dep|signaling	BDNF signaling in the rat cerebello-vestibular pathway during vestibular compensation : BDNF signaling in vestibular compensation .
19555760	0	BDNF	0,4	BIM	15,18	BDNF	BIM	627	10018	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	BDNF regulates BIM expression levels in 3-nitropropionic_acid-treated cortical neurons .
22500623	0	BDNF	34,38	BMP	54,57	BDNF	BMP	627	649	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Axonally translated SMADs link up BDNF and retrograde BMP signaling .
21640793	0	BDNF	80,84	Brain-Derived_Neurotrophic_Factor	45,78	BDNF	Brain-Derived Neurotrophic Factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between Val66Met polymorphism of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- gene and a deficiency_of_colour_vision in alcohol-dependent male patients .
25634725	0	BDNF	77,81	Brain-Derived_Neurotrophic_Factor	42,75	BDNF	Brain-Derived Neurotrophic Factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Differential Expression and Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- mRNA Isoforms in Brain Cells from Mecp2 -LRB- 308/y -RRB- Mouse Model .
12142916	0	BDNF	49,53	Brain-derived_Neurotrophic_Factor	14,47	BDNF	Brain-derived Neurotrophic Factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Expression of Brain-derived_Neurotrophic_Factor -LRB- BDNF -RRB- Gene in Rat Myoblast Cells .
26849417	0	BDNF	52,56	Brain-derived_Neurotrophic_Factor	17,50	BDNF	Brain-derived Neurotrophic Factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Transfer|appos|START_ENTITY Transfer|nmod|END_ENTITY	Gene Transfer of Brain-derived_Neurotrophic_Factor -LRB- BDNF -RRB- Prevents Neurodegeneration Triggered by FXN Deficiency .
12426055	0	BDNF	35,39	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus .
17012654	0	BDNF	35,39	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and rapid-cycling bipolar_disorder : family-based association study .
19236730	0	BDNF	36,40	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene : no major impact on antidepressant treatment response .
21616543	0	BDNF	35,39	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- plasma levels in drug-na ve OCD patients are lower than those in healthy people , but are not lower than those in drug-treated OCD patients .
21695421	0	BDNF	35,39	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene : a gender-specific role in cognitive function during normal cognitive_aging of the MEMO-Study ?
21924942	0	BDNF	35,39	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- genetic polymorphism greatly increases risk of leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- for Parkinson 's _ disease .
23933054	0	BDNF	53,57	Brain-derived_neurotrophic_factor	18,51	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Changes in plasma Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels induced by methylphenidate in children with Attention_deficit-hyperactivity_disorder -LRB- ADHD -RRB- .
25001952	0	BDNF	35,39	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism affects sympathetic tone in a gender-specific way .
25438605	0	BDNF	41,45	Brain-derived_neurotrophic_factor	1,34	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- polymorphism among Moscow citizens -RSB- .
25508136	0	BDNF	41,45	Brain-derived_neurotrophic_factor	1,34	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- polymorphism among Moscow citizens -RSB- .
25640836	0	BDNF	35,39	Brain-derived_neurotrophic_factor	0,33	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes .
24112874	0	BDNF	35,39	Brain_Derived_Neurotrophic_Factor	0,33	BDNF	Brain Derived Neurotrophic Factor	627	627	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Brain_Derived_Neurotrophic_Factor -LRB- BDNF -RRB- levels as a possible predictor of psychopathology in healthy twins at high and low risk for affective_disorder .
22194877	0	BDNF	35,39	Brain_derived_neurotrophic_factor	0,33	BDNF	Brain derived neurotrophic factor	627	627	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Brain_derived_neurotrophic_factor -LRB- BDNF -RRB- expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding .
23793276	0	BDNF	35,39	Brain_derived_neurotrophic_factor	0,33	BDNF	Brain derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Brain_derived_neurotrophic_factor -LRB- BDNF -RRB- levels in depressed women treated with open-label escitalopram .
25132151	0	BDNF	40,44	Brain_derived_neurotrophic_factor	0,33	BDNF	Brain derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Brain_derived_neurotrophic_factor gene -LRB- BDNF -RRB- and personality traits : The modifying effect of season of birth and sex .
15465029	0	BDNF	26,30	Brn-3c	0,6	BDNF	Brn-3c	12064(Tax:10090)	18998(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Brn-3c -LRB- POU4F3 -RRB- regulates BDNF and NT-3 promoter activity .
19777340	0	BDNF	49,53	CDNF	98,102	BDNF	CDNF	12064(Tax:10090)	227526(Tax:10090)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and cerebral_dopamine_neurotrophic_factor -LRB- CDNF -RRB- by anti-parkinsonian drug therapy in vivo .
18381242	0	BDNF	0,4	CaMKIV	15,21	BDNF	CaMKIV	627	814	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth .
23065263	0	BDNF	82,86	DAT1	114,118	BDNF	DAT1	627	6531	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	DNA methylation and expression profiles of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and dopamine_transporter -LRB- DAT1 -RRB- genes in patients with schizophrenia .
25301525	0	BDNF	50,54	ELP4	89,93	BDNF	ELP4	627	26610	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Association of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and elongator_protein_complex_4 -LRB- ELP4 -RRB- polymorphisms with benign_epilepsy with centrotemporal_spikes in a Greek population .
21228173	0	BDNF	33,37	Early_growth_response_4	0,23	BDNF	Early growth response 4	627	1961	Gene	Gene	induction|compound|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Early_growth_response_4 mediates BDNF induction of potassium_chloride cotransporter 2 transcription .
21448920	0	BDNF	0,4	GLAST	15,20	BDNF	GLAST	12064(Tax:10090)	20512(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BDNF regulates GLAST and glutamine_synthetase in mouse retinal M ller cells .
17284422	0	BDNF	37,41	GRIN1	30,35	BDNF	GRIN1	627	2902	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	-LSB- An association study between GRIN1 , BDNF genes and bipolar_disorder -RSB- .
20689988	0	BDNF	31,35	Galectin-1	0,10	BDNF	Galectin-1	24225(Tax:10116)	3956	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia .
26200505	0	BDNF	0,4	GlyT1	45,50	BDNF	GlyT1	24225(Tax:10116)	116509(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	BDNF , via truncated TrkB receptor , modulates GlyT1 and GlyT2 in astrocytes .
15233743	0	BDNF	24,28	GnRH	74,78	BDNF	GnRH	627	2796	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neurotrophic effects of BDNF on embryonic gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons .
24141084	0	BDNF	59,63	MMP-9	97,102	BDNF	MMP-9	627	4318	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Plasma levels of mature brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in treatment-resistant schizophrenia treated with clozapine .
14593183	0	BDNF	16,20	MeCP2	81,86	BDNF	MeCP2	12064(Tax:10090)	17257(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY Derepression|nmod|transcription involves|nsubj|Derepression involves|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 .
14988922	0	BDNF	74,78	MeCP2	93,98	BDNF	MeCP2	627	4204	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Dynamic regulation of DNA methylation coupled transcriptional repression : BDNF regulation by MeCP2 .
18075316	0	BDNF	40,44	MeCP2	0,5	BDNF	MeCP2	627	4204	Gene	Gene	levels|amod|START_ENTITY decreases|dobj|levels decreases|nsubj|deficiency_in_the_brain deficiency_in_the_brain|amod|END_ENTITY	MeCP2 deficiency_in_the_brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production .
20711185	0	BDNF	15,19	MeCP2	0,5	BDNF	MeCP2	627	4204	Gene	Gene	START_ENTITY|nsubj|controls controls|amod|END_ENTITY	MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212 .
22677942	0	BDNF	53,57	MeCP2	32,37	BDNF	MeCP2	627	4204	Gene	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|deacetylation deacetylation|nmod|END_ENTITY	SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression .
25579386	0	BDNF	65,69	MeCP2	104,109	BDNF	MeCP2	627	4204	Gene	Gene	Brain-Derived_Neurotrophic_Factor|appos|START_ENTITY Brain-Derived_Neurotrophic_Factor|nmod|Protein Protein|appos|END_ENTITY	Transcriptional Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- by Methyl_CpG Binding Protein 2 -LRB- MeCP2 -RRB- : a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple_Sclerosis -LRB- MS -RRB- .
16446138	0	BDNF	73,77	Mecp2	27,32	BDNF	Mecp2	12064(Tax:10090)	17257(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY level|nmod|expression affected|nmod|level affected|nsubjpass|progression progression|nmod|mice mice|amod|END_ENTITY	The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression .
23027959	0	BDNF	19,23	Mecp2	89,94	BDNF	Mecp2	12064(Tax:10090)	17257(Tax:10090)	Gene	Gene	release|amod|START_ENTITY impaired|nsubjpass|release impaired|nmod|neurons neurons|nmod|mice mice|amod|END_ENTITY	Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice .
24639629	0	BDNF	53,57	Mecp2	98,103	BDNF	Mecp2	12064(Tax:10090)	17257(Tax:10090)	Gene	Gene	trafficking|amod|START_ENTITY improves|dobj|trafficking improves|nmod|neurons neurons|nmod|mice mice|amod|END_ENTITY	A selective histone_deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice : implications for Rett_syndrome .
25634725	0	BDNF	77,81	Mecp2	117,122	BDNF	Mecp2	12064(Tax:10090)	17257(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY Expression|nmod|mRNA Isoforms|nsubj|Expression Isoforms|nmod|END_ENTITY	Differential Expression and Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- mRNA Isoforms in Brain Cells from Mecp2 -LRB- 308/y -RRB- Mouse Model .
27013094	0	BDNF	94,98	NF-kB	61,66	BDNF	NF-kB	24225(Tax:10116)	309165(Tax:10116)	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Venenum Bufonis induces rat neuroinflammation by activiating NF-kB pathway and attenuation of BDNF .
10698011	0	BDNF	152,156	NGF	108,111	BDNF	NGF	24225(Tax:10116)	310738(Tax:10116)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	GABA -LRB- B -RRB- receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve_growth_factor -LRB- NGF -RRB- and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- in brain and spinal cord of rats .
10817624	0	BDNF	89,93	NGF	120,123	BDNF	NGF	627	4803	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Mapping the differences in the brain concentration of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- in an animal model of depression .
15169782	0	BDNF	72,76	NGF	103,106	BDNF	NGF	627	4803	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Paracrine and autocrine functions of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- in brain-derived endothelial cells .
25314897	0	BDNF	82,86	NGF	113,116	BDNF	NGF	24225(Tax:10116)	310738(Tax:10116)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	The exposure to nicotine affects expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- in neonate rats .
8366347	0	BDNF	61,65	NGF	92,95	BDNF	NGF	24225(Tax:10116)	310738(Tax:10116)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Cholinergic regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- mRNA levels in the developing rat hippocampus .
9299533	0	BDNF	77,81	NGF	108,111	BDNF	NGF	12064(Tax:10090)	18049(Tax:10090)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Dopaminergic transmitter up-regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- synthesis in mouse astrocytes in culture .
26548545	0	BDNF	51,55	NT-3	77,81	BDNF	NT-3	627	4908	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Serum levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and neurotrophin-3 -LRB- NT-3 -RRB- in depressed patients with schizophrenia .
8724667	0	BDNF	12,16	NT-3	0,4	BDNF	NT-3	12064(Tax:10090)	18205(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	NT-3 and/or BDNF therapy prevents loss_of_auditory_neurons following loss of hair cells .
10051762	0	BDNF	127,131	NT3	153,156	BDNF	NT3	627	4908	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Distinct populations of hypothalamic dopaminergic neurons exhibit differential responses to brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and neurotrophin-3 -LRB- NT3 -RRB- .
26061800	0	BDNF	111,115	OXTR	140,144	BDNF	OXTR	627	5021	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Childhood maternal care is associated with DNA methylation of the genes for brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and oxytocin_receptor -LRB- OXTR -RRB- in peripheral blood cells in adult men and women .
20410295	0	BDNF	25,29	RACK1	69,74	BDNF	RACK1	627	10399	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Epigenetic regulation of BDNF expression via the scaffolding protein RACK1 .
26223799	0	BDNF	0,4	Striatal-Enriched_Protein_Tyrosine_Phosphatase	13,59	BDNF	Striatal-Enriched Protein Tyrosine Phosphatase	627	84867	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	BDNF Induces Striatal-Enriched_Protein_Tyrosine_Phosphatase 61 Degradation Through the Proteasome .
26376051	0	BDNF	56,60	TNF-a	95,100	BDNF	TNF-a	627	7124	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Association of serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- with diagnosis of delirium in oncology inpatients .
10679773	0	BDNF	80,84	TrkB	0,4	BDNF	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|expression expression|amod|END_ENTITY	TrkB expression and early sensory neuron survival are independent of endogenous BDNF .
10711692	0	BDNF	31,35	TrkB	53,57	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	transport|nmod|START_ENTITY END_ENTITY|nsubj|transport	Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma .
10899288	0	BDNF	55,59	TrkB	10,14	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	endocytosis|nmod|START_ENTITY mediates|dobj|endocytosis mediates|nsubj|END_ENTITY	Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4 / 5 by rat astrocytes and schwann cells in vitro .
11553298	0	BDNF	0,4	TrkB	57,61	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|mRNA mRNA|nmod|neurons neurons|compound|END_ENTITY	BDNF increases the early expression of TRH mRNA in fetal TrkB + hypothalamic neurons in primary culture .
11855816	0	BDNF	75,79	TrkB	31,35	BDNF	TrkB	627	4915	Gene	Gene	sites|nmod|START_ENTITY defines|dobj|sites defines|nsubj|domain domain|nmod|receptor receptor|compound|END_ENTITY	A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4 .
12614342	0	BDNF	0,4	TrkB	93,97	BDNF	TrkB	627	4915	Gene	Gene	heightens|nsubj|START_ENTITY heightens|nmod|activation activation|nmod|END_ENTITY	BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB .
15518646	0	BDNF	22,26	TrkB	58,62	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise .
16173113	0	BDNF	64,68	TrkB	19,23	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Cellular levels of TrkB and MAPK in the neuroprotective role of BDNF for embryonic rat cortical neurons against hypoxia in vitro .
17711418	0	BDNF	56,60	TrkB	22,26	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	expressions|compound|START_ENTITY increases|nmod|expressions induces|dobj|increases induces|nsubj|stimulation stimulation|nmod|END_ENTITY	Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms .
17883412	0	BDNF	0,4	TrkB	6,10	BDNF	TrkB	627	4915	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|interaction interaction|compound|END_ENTITY	BDNF / TrkB interaction regulates migration of SVZ precursor cells via PI3-K and MAP-K signalling pathways .
19424097	0	BDNF	21,25	TrkB	45,49	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	START_ENTITY|dobj|receptor receptor|compound|END_ENTITY	Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture .
20407211	0	BDNF	15,19	TrkB	38,42	BDNF	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	mimetics|compound|START_ENTITY activate|nsubj|mimetics activate|ccomp|signaling signaling|nsubj|END_ENTITY	Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal_degeneration in rodents .
20428771	0	BDNF	0,4	TrkB	14,18	BDNF	TrkB	627	4915	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|signal signal|nsubj|activation activation|compound|END_ENTITY	BDNF mediated TrkB activation is a survival signal for transitional_cell_carcinoma cells .
20635439	0	BDNF	74,78	TrkB	118,122	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Acute stress and chronic stress change brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and tyrosine kinase-coupled receptor -LRB- TrkB -RRB- expression in both young and aged rat hippocampus .
20843342	0	BDNF	133,137	TrkB	139,143	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Dietary supplementation of soy germ phytoestrogens or estradiol improves spatial memory performance and increases gene expression of BDNF , TrkB receptor and synaptic factors in ovariectomized rats .
21196945	0	BDNF	86,90	TrkB	110,114	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Effects of chronic forced swim stress on hippocampal brain-derived neutrophic factor -LRB- BDNF -RRB- and its receptor -LRB- TrkB -RRB- immunoreactive cells in juvenile and aged rats .
21281620	0	BDNF	63,67	TrkB	45,49	BDNF	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice .
21666748	0	BDNF	106,110	TrkB	35,39	BDNF	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	brain|nmod|START_ENTITY transactivate|nmod|brain transactivate|dobj|receptors receptors|compound|END_ENTITY	Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade .
21775604	0	BDNF	61,65	TrkB	97,101	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|bridging bridging|dobj|END_ENTITY	JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1 .
22374757	0	BDNF	116,120	TrkB	0,4	BDNF	TrkB	627	4915	Gene	Gene	effects|nmod|START_ENTITY mediates|xcomp|effects tractus|ccomp|mediates tractus|nsubj|receptor receptor|amod|END_ENTITY	TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin .
22396798	0	BDNF	30,34	TrkB	22,26	BDNF	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	drugs|compound|START_ENTITY END_ENTITY|nmod|drugs	The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development .
22560237	0	BDNF	131,135	TrkB	21,25	BDNF	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	prevent|nmod|START_ENTITY prevent|nsubj|antagonist antagonist|compound|END_ENTITY	Cyclotraxin-B , a new TrkB antagonist , and glial blockade by propentofylline , equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital_nerve_constriction in mice .
23086941	0	BDNF	120,124	TrkB	66,70	BDNF	TrkB	627	4915	Gene	Gene	tropomyosin-related_kinase_B|appos|START_ENTITY tropomyosin-related_kinase_B|appos|END_ENTITY	LIM_kinase_1 -LRB- LIMK1 -RRB- interacts with tropomyosin-related_kinase_B -LRB- TrkB -RRB- and Mediates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced axonal elongation .
23977241	0	BDNF	71,75	TrkB	30,34	BDNF	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|trafficking trafficking|nmod|END_ENTITY	SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF .
24867303	0	BDNF	78,82	TrkB	46,50	BDNF	TrkB	627	4915	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF .
24934279	0	BDNF	43,47	TrkB	0,4	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	accelerates|nsubj|START_ENTITY mechanism|acl:relcl|accelerates involved|nmod|mechanism involved|nsubjpass|END_ENTITY	TrkB is involved in the mechanism by which BDNF accelerates the glutamate-induced death of rat neuroblastoma B35 cells .
25012754	0	BDNF	40,44	TrkB	22,26	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|responsiveness responsiveness|nmod|END_ENTITY	The responsiveness of TrkB to exogenous BDNF in frontal cortex during antibiotic treatment of Streptococcus_pneumoniae_meningitis .
25456007	0	BDNF	0,4	TrkB	14,18	BDNF	TrkB	627	4915	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|contributes contributes|nsubj|activation activation|compound|END_ENTITY	BDNF mediated TrkB activation contributes to the EMT progression and the poor prognosis in human salivary_adenoid_cystic_carcinoma .
26200505	0	BDNF	0,4	TrkB	20,24	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	BDNF , via truncated TrkB receptor , modulates GlyT1 and GlyT2 in astrocytes .
26786147	0	BDNF	35,39	TrkB	43,47	BDNF	TrkB	627	4915	Gene	Gene	Brain-derived_neurotrophic_factor|appos|START_ENTITY Brain-derived_neurotrophic_factor|dep|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - TrkB signaling in inflammation-related_depression and potential therapeutic targets .
7961713	1	BDNF	94,98	TrkB	149,153	BDNF	TrkB	627	4915	Gene	Gene	heterodimer|nsubj|START_ENTITY heterodimer|nmod|domains domains|nmod|receptors receptors|compound|END_ENTITY	BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors .
8394722	0	BDNF	71,75	TrkB	13,17	BDNF	TrkB	627	4915	Gene	Gene	responsiveness|nmod|START_ENTITY mediates|dobj|responsiveness mediates|nsubj|Induction Induction|nmod|END_ENTITY	Induction of TrkB by retinoic_acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells .
8752592	0	BDNF	0,4	TrkB	49,53	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	responsiveness|amod|START_ENTITY responsiveness|appos|protein protein|compound|END_ENTITY	BDNF down-regulates neurotrophin responsiveness , TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons .
8911685	0	BDNF	62,66	TrkB	92,96	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Activation of Ras and protection from apoptotic cell death by BDNF in PC12 cells expressing TrkB .
9184109	0	BDNF	11,15	TrkB	46,50	BDNF	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	infusion|compound|START_ENTITY Effects|nmod|infusion Effects|nmod|regulation regulation|nmod|protein protein|compound|END_ENTITY	Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain .
23973291	0	BDNF	48,52	activin_A	28,37	BDNF	activin A	627	29200(Tax:10116)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	TGF-beta superfamily member activin_A acts with BDNF and erythropoietin to improve survival of spiral_ganglion_neurons in vitro .
15110760	0	BDNF	0,4	alpha-synuclein	29,44	BDNF	alpha-synuclein	627	6622	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	BDNF is induced by wild-type alpha-synuclein but not by the two mutants , A30P or A53T , in glioma cell line .
20405200	0	BDNF	49,53	alpha-synuclein	18,33	BDNF	alpha-synuclein	627	6622	Gene	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|down-regulates down-regulates|amod|END_ENTITY	Overexpression of alpha-synuclein down-regulates BDNF expression .
16634055	0	BDNF	47,51	aspartoacylase	15,29	BDNF	aspartoacylase	24225(Tax:10116)	79251(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis .
11244490	0	BDNF	63,67	brain-derived_neurotrophic_factor	28,61	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel polymorphism of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene associated with late-onset Alzheimer 's _ disease .
11338187	0	BDNF	54,58	brain-derived_neurotrophic_factor	19,52	BDNF	brain-derived neurotrophic factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dopamine regulates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in cultured embryonic mouse striatal cells .
11483252	0	BDNF	56,60	brain-derived_neurotrophic_factor	21,54	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Transient changes of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA expression in hippocampus during moderate ischemia induced by chronic bilateral common carotid artery occlusions in the rat .
12524161	0	BDNF	60,64	brain-derived_neurotrophic_factor	25,58	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene with bipolar_disorder .
12836135	0	BDNF	60,64	brain-derived_neurotrophic_factor	25,58	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence variants of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene are strongly associated with obsessive-compulsive_disorder .
12923891	0	BDNF	50,54	brain-derived_neurotrophic_factor	15,48	BDNF	brain-derived neurotrophic factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the development of periodontal Ruffini endings .
14583394	0	BDNF	41,45	brain-derived_neurotrophic_factor	6,39	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in schizophrenia are indistinguishable from controls .
14730195	0	BDNF	58,62	brain-derived_neurotrophic_factor	23,56	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association study of a brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism and personality trait and intelligence in healthy young females .
14736076	0	BDNF	49,53	brain-derived_neurotrophic_factor	14,47	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression following antibiotic treatment of experimental bacterial_meningitis .
15053962	0	BDNF	58,62	brain-derived_neurotrophic_factor	23,56	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression analysis of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA isoforms after chronic and acute antidepressant treatment .
15274036	0	BDNF	58,62	brain-derived_neurotrophic_factor	23,56	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	association|appos|START_ENTITY association|amod|END_ENTITY	Non-replication of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- association in bipolar_affective_disorder : a Belgian patient-control study .
15659231	0	BDNF	46,50	brain-derived_neurotrophic_factor	11,44	BDNF	brain-derived neurotrophic factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on glial cells and serotonergic neurones during development .
15791923	0	BDNF	62,66	brain-derived_neurotrophic_factor	27,60	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on hearing in experimental_pneumococcal_meningitis .
15837118	0	BDNF	179,183	brain-derived_neurotrophic_factor	144,177	BDNF	brain-derived neurotrophic factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Social threat and novel cage stress-induced sustained extracellular-regulated kinase1/2 -LRB- ERK1/2 -RRB- phosphorylation but differential modulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in the hippocampus of NMRI mice .
15860348	0	BDNF	39,43	brain-derived_neurotrophic_factor	4,37	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Low brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity .
15905010	0	BDNF	41,45	brain-derived_neurotrophic_factor	6,39	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in patients with panic_disorder : as a biological predictor of response to group cognitive behavioral therapy .
15913870	0	BDNF	57,61	brain-derived_neurotrophic_factor	22,55	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene polymorphisms with panic_disorder .
15940292	0	BDNF	142,146	brain-derived_neurotrophic_factor	107,140	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene with susceptibility to ADHD .
15949651	0	BDNF	57,61	brain-derived_neurotrophic_factor	22,55	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene C-270T polymorphism with schizophrenia .
16043130	0	BDNF	70,74	brain-derived_neurotrophic_factor	35,68	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Val66Met coding variant of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene does not contribute toward variation in the personality trait neuroticism .
16054753	0	BDNF	59,63	brain-derived_neurotrophic_factor	24,57	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene 196_A / G polymorphism with Alzheimer 's _ disease -LRB- AD -RRB- in mainland Chinese .
16061712	0	BDNF	49,53	brain-derived_neurotrophic_factor	14,47	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- during sleep apnoea treatment .
16105728	0	BDNF	81,85	brain-derived_neurotrophic_factor	46,79	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between variations in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and temporal_lobe_epilepsy .
16139165	0	BDNF	53,57	brain-derived_neurotrophic_factor	18,51	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No implication of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene in unipolar_affective_disorder : evidence from Belgian first and replication patient-control studies .
16152572	0	BDNF	104,108	brain-derived_neurotrophic_factor	69,102	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Confirmation of association between the Val66Met polymorphism in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and bipolar_I_disorder .
16568151	0	BDNF	71,75	brain-derived_neurotrophic_factor	36,69	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A complex polymorphic region in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene confers susceptibility to bipolar_disorder and affects transcriptional activity .
16626638	0	BDNF	74,78	brain-derived_neurotrophic_factor	39,72	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Chronic stress induces upregulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and integrin alpha5 expression in the rat pineal gland .
16876769	0	BDNF	68,72	brain-derived_neurotrophic_factor	33,66	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Chronic corticosterone decreases brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and protein in the hippocampus , but not in the frontal cortex , of the rat .
17130481	0	BDNF	162,166	brain-derived_neurotrophic_factor	127,160	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hyperphagia , severe obesity , impaired_cognitive_function , and hyperactivity associated with functional loss of one copy of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
17267117	0	BDNF	62,66	brain-derived_neurotrophic_factor	27,60	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	No association between the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism and schizophrenia in Asian populations : Evidence from a case-control study and meta-analysis .
17344400	0	BDNF	80,84	brain-derived_neurotrophic_factor	45,78	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Oligomeric amyloid decreases basal levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells .
17349978	0	BDNF	59,63	brain-derived_neurotrophic_factor	24,57	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic analyses of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene in autism .
17427191	0	BDNF	39,43	brain-derived_neurotrophic_factor	4,37	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Low brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in serum of Huntington 's _ disease patients .
17459549	0	BDNF	163,167	brain-derived_neurotrophic_factor	128,161	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol -LRB- MHPG -RRB- levels , but did not alter plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in schizophrenic patients .
17628454	0	BDNF	53,57	brain-derived_neurotrophic_factor	18,51	BDNF	brain-derived neurotrophic factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Acute role of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on the respiratory neural network activity in mice in vitro .
17825920	0	BDNF	130,134	brain-derived_neurotrophic_factor	95,128	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Acute prefrontal cortex transcranial magnetic stimulation in healthy volunteers : no effects on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- concentrations in serum .
17923424	0	BDNF	134,138	brain-derived_neurotrophic_factor	99,132	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Emergence of an egocentric cue guiding and allocentric inferring strategy that mirrors hippocampal brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in the Morris water maze .
17928160	0	BDNF	96,100	brain-derived_neurotrophic_factor	61,94	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Neuroactive steroids modulate HPA_axis activity and cerebral brain-derived_neurotrophic_factor -LRB- BDNF -RRB- protein levels in adult male rats .
17950272	0	BDNF	58,62	brain-derived_neurotrophic_factor	23,56	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Temporal expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants .
18160197	0	BDNF	156,160	brain-derived_neurotrophic_factor	28,61	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Stress at work alters serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and plasma 3-methoxy-4-hydroxyphenylglycol -LRB- MHPG -RRB- levels in healthy volunteers : BDNF and MHPG as possible biological markers of mental_stress ?
18160197	0	BDNF	63,67	brain-derived_neurotrophic_factor	28,61	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Stress at work alters serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and plasma 3-methoxy-4-hydroxyphenylglycol -LRB- MHPG -RRB- levels in healthy volunteers : BDNF and MHPG as possible biological markers of mental_stress ?
18348609	0	BDNF	59,63	brain-derived_neurotrophic_factor	24,57	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the innervation of dopaminergic neurons from the rat periventricular nucleus to the pars intermedia .
18457678	0	BDNF	150,154	brain-derived_neurotrophic_factor	115,148	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
18474368	0	BDNF	48,52	brain-derived_neurotrophic_factor	13,46	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on serotonin neurotransmission in the hippocampus of adult rodents .
18544182	0	BDNF	131,135	brain-derived_neurotrophic_factor	96,129	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and histone acetylation at its promoters in the rat hippocampus .
18807247	0	BDNF	82,86	brain-derived_neurotrophic_factor	47,80	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Preliminary evidence of cannabinoid effects on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in humans .
18842305	0	BDNF	48,52	brain-derived_neurotrophic_factor	13,46	BDNF	Brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variation in brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene is associated with symptoms of depression .
18845611	0	BDNF	69,73	brain-derived_neurotrophic_factor	29,62	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common polymorphism in the brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- modulates human cortical plasticity and the response to rTMS .
19088493	0	BDNF	61,65	brain-derived_neurotrophic_factor	21,54	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Meta-analysis of the brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- Val66Met polymorphism in anxiety_disorders and anxiety-related_personality traits .
19170664	0	BDNF	64,68	brain-derived_neurotrophic_factor	29,62	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between Val66Met brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene polymorphism and post-treatment relapse in alcohol_dependence .
19255578	0	BDNF	67,71	brain-derived_neurotrophic_factor	32,65	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Population genetic study of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
19337469	0	BDNF	64,68	brain-derived_neurotrophic_factor	29,62	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Continuous decrease in serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in a neuropsychiatric_syndrome of systemic_lupus_erythematosus patient with organic brain changes .
19622243	0	BDNF	82,86	brain-derived_neurotrophic_factor	47,80	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between leptin_receptor -LRB- LEPR -RRB- and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene variants and obesity : a case-control study .
20004415	0	BDNF	162,166	brain-derived_neurotrophic_factor	127,160	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
20172535	0	BDNF	49,53	brain-derived_neurotrophic_factor	14,47	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment .
20434315	0	BDNF	90,94	brain-derived_neurotrophic_factor	55,88	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Comparison of brain N-acetylaspartate levels and serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels between patients with first-episode schizophrenia_psychosis and healthy controls .
20482942	0	BDNF	55,59	brain-derived_neurotrophic_factor	20,53	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fine-mapping of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene supports an association of the Val66Met polymorphism with episodic memory .
20643185	0	BDNF	77,81	brain-derived_neurotrophic_factor	42,75	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Differential expression and regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA isoforms in androgen-sensitive motoneurons of the rat lumbar spinal cord .
20797911	0	BDNF	50,54	brain-derived_neurotrophic_factor	15,48	BDNF	brain-derived neurotrophic factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in MP4-induced autoimmune encephalomyelitis .
20970479	0	BDNF	131,135	brain-derived_neurotrophic_factor	96,129	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Quadri-pulse stimulation -LRB- QPS -RRB- induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
21098877	0	BDNF	57,61	brain-derived_neurotrophic_factor	22,55	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Family-based study of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene polymorphism in alcohol_dependence .
21179660	0	BDNF	52,56	brain-derived_neurotrophic_factor	17,50	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	-LSB- Blood levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in major depressive_disorder -RSB- .
21188516	0	BDNF	89,93	brain-derived_neurotrophic_factor	54,87	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Total and mitochondrial nitrosative stress , decreased brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and glutamate uptake , and evidence of endoplasmic reticulum stress in the hippocampus of vitamin_A-treated rats .
21684022	0	BDNF	88,92	brain-derived_neurotrophic_factor	53,86	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Physical therapy intervention -LRB- PTI -RRB- increases plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in non-frail and pre-frail elderly women .
21889574	0	BDNF	97,101	brain-derived_neurotrophic_factor	62,95	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis between the Val66Met polymorphism in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and treatment response to venlafaxine_XR in generalized_anxiety_disorder .
21912609	0	BDNF	67,71	brain-derived_neurotrophic_factor	32,65	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA methylation profiles of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene as a potent diagnostic biomarker in major depression .
22005283	0	BDNF	82,86	brain-derived_neurotrophic_factor	47,80	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The effect of the Mediterranean diet on plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels : the PREDIMED-NAVARRA randomized trial .
22085476	0	BDNF	93,97	brain-derived_neurotrophic_factor	58,91	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence of associations between bipolar_disorder and the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
22218230	0	BDNF	21,25	brain-derived_neurotrophic_factor	59,92	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of serum BDNF and val66met polymorphism of the brain-derived_neurotrophic_factor in a sample of first psychotic_episode patients .
22642961	0	BDNF	47,51	brain-derived_neurotrophic_factor	12,45	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The role of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene variants in antipsychotic response and antipsychotic-induced weight_gain .
22672085	0	BDNF	67,71	brain-derived_neurotrophic_factor	32,65	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Robust changes in expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma .
22810739	0	BDNF	67,71	brain-derived_neurotrophic_factor	32,65	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	-LSB- The prognostic significance of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- for phobic_anxiety_disorders , vegetative_and_cognitive_impairments during conservative treatment including adaptol of some functional and organic diseases of nervous system -RSB- .
22900512	0	BDNF	50,54	brain-derived_neurotrophic_factor	15,48	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	Expressions|appos|START_ENTITY Expressions|nmod|END_ENTITY	Expressions of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in cerebrospinal fluid and plasma of children with meningitis and encephalitis/encephalopathy .
22965830	0	BDNF	51,55	brain-derived_neurotrophic_factor	16,49	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	No influence of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- polymorphisms on treatment response in a naturalistic sample of patients with major_depression .
23012486	0	BDNF	66,70	brain-derived_neurotrophic_factor	31,64	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression and localization of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and protein in human submandibular gland .
23209335	0	BDNF	58,62	brain-derived_neurotrophic_factor	23,56	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of stress-related brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the rat submandibular gland .
23522997	0	BDNF	112,116	brain-derived_neurotrophic_factor	77,110	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Combined therapeutic effect of udenafil and adipose-derived stem cell -LRB- ADSC -RRB- / brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - membrane system in a rat model of cavernous_nerve_injury .
23570723	0	BDNF	51,55	brain-derived_neurotrophic_factor	16,49	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increased serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in patients with narcolepsy .
23812866	0	BDNF	41,45	brain-derived_neurotrophic_factor	6,39	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in attention_deficit-hyperactivity_disorder -LRB- ADHD -RRB- .
23838134	0	BDNF	59,63	brain-derived_neurotrophic_factor	24,57	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- are decreased in colorectal_cancer patients .
23844985	0	BDNF	70,74	brain-derived_neurotrophic_factor	35,68	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Decreased plasma concentrations of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in patients with functional hypothalamic amenorrhea .
24255678	0	BDNF	59,63	brain-derived_neurotrophic_factor	24,57	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	Biological influence of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on colon_cancer cells .
24346357	0	BDNF	68,72	brain-derived_neurotrophic_factor	33,66	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Histone deacetylase activity and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in a pharmacological model of mania .
24467931	0	BDNF	180,184	brain-derived_neurotrophic_factor	145,178	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Altered plasma glutathione levels in bipolar_disorder indicates higher oxidative stress ; a possible risk factor for illness onset despite normal brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
24621065	0	BDNF	68,72	brain-derived_neurotrophic_factor	33,66	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Zinc monotherapy increases serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and decreases_depressive_symptoms in overweight or obese subjects : A double-blind , randomized , placebo-controlled trial .
24660789	0	BDNF	67,71	brain-derived_neurotrophic_factor	32,65	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Val/Met polymorphism of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene predicts decline in perceptual speed in older adults .
24708359	0	BDNF	52,56	brain-derived_neurotrophic_factor	17,50	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Investigation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene variants in migraine .
24713358	0	BDNF	63,67	brain-derived_neurotrophic_factor	28,61	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Sex-specific association of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity _ disorder in a drug-na ve Han Chinese sample .
24966334	0	BDNF	84,88	brain-derived_neurotrophic_factor	49,82	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Persistent inflammation-induced up-regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- promotes synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid receptor GluA1 subunits in descending pain modulatory circuits .
25237300	0	BDNF	53,57	brain-derived_neurotrophic_factor	18,51	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Disruption of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- immunoreactivity in the human K lliker-Fuse nucleus in victims of unexplained fetal and infant death .
25305432	0	BDNF	62,66	brain-derived_neurotrophic_factor	27,60	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Decreased plasma levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- during mixed episodes of bipolar_disorder .
25328348	0	BDNF	41,45	brain-derived_neurotrophic_factor	6,39	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in schizophrenia : A systematic review .
25653370	0	BDNF	47,51	brain-derived_neurotrophic_factor	12,45	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the development of neurogenic detrusor overactivity -LRB- NDO -RRB- .
25710846	0	BDNF	68,72	brain-derived_neurotrophic_factor	33,66	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Meta-analysis and association of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene with obsessive-compulsive_disorder .
26347681	0	BDNF	39,43	brain-derived_neurotrophic_factor	4,37	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The brain-derived_neurotrophic_factor -LRB- BDNF -RRB- val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition -LRB- WMS-III -RRB- .
26347681	0	BDNF	39,43	brain-derived_neurotrophic_factor	4,37	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The brain-derived_neurotrophic_factor -LRB- BDNF -RRB- val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition -LRB- WMS-III -RRB- .
26531275	0	BDNF	90,94	brain-derived_neurotrophic_factor	55,88	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Effect of different anesthesia techniques on the serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
26736083	0	BDNF	49,53	brain-derived_neurotrophic_factor	14,47	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA in rat retrosplenial cortex following administration of phencyclidine .
7906555	0	BDNF	74,78	brain-derived_neurotrophic_factor	39,72	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Activation of NMDA receptors increases brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA expression in the hippocampal formation .
8126563	0	BDNF	49,53	brain-derived_neurotrophic_factor	14,47	BDNF	brain-derived neurotrophic factor	627	627	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors .
9065491	0	BDNF	51,55	brain-derived_neurotrophic_factor	16,49	BDNF	brain-derived neurotrophic factor	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Distribution of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- protein and mRNA in the normal adult rat CNS : evidence for anterograde axonal transport .
9842514	0	BDNF	81,85	brain-derived_neurotrophic_factor	46,79	BDNF	brain-derived neurotrophic factor	100135487(Tax:10141)	100135487(Tax:10141)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Unilateral vestibular deafferentation induces brain-derived_neurotrophic_factor -LRB- BDNF -RRB- protein expression in the guinea_pig lateral but not medial vestibular nuclei .
17918236	0	BDNF	59,63	brain-derived_neurotropic_factor	25,57	BDNF	brain-derived neurotropic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of the brain-derived_neurotropic_factor -LRB- BDNF -RRB- gene in attention deficit_hyperactivity_disorder .
15457498	0	BDNF	63,67	brain_derived_neurotrophic_factor	23,56	BDNF	brain derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation screen of the brain_derived_neurotrophic_factor gene -LRB- BDNF -RRB- : identification of several genetic variants and association studies in patients with obesity , eating_disorders , and attention-deficit/hyperactivity _ disorder .
16054725	0	BDNF	58,62	brain_derived_neurotrophic_factor	23,56	BDNF	brain derived neurotrophic factor	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regional expression of brain_derived_neurotrophic_factor -LRB- BDNF -RRB- is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain .
23271640	0	BDNF	53,57	brain_derived_neurotrophic_factor	18,51	BDNF	brain derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Reduced levels of brain_derived_neurotrophic_factor -LRB- BDNF -RRB- in the serum of diabetic_retinopathy patients and in the retina of diabetic rats .
24361909	0	BDNF	73,77	brain_derived_neurotrophic_factor	38,71	BDNF	brain derived neurotrophic factor	627	627	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Chronic estradiol treatment decreases brain_derived_neurotrophic_factor -LRB- BDNF -RRB- expression and monoamine levels in the amygdala -- implications for behavioral_disorders .
26118823	0	BDNF	167,171	brain_derived_neurotrophic_factor	132,165	BDNF	brain derived neurotrophic factor	627	627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Development of a cost-efficient novel method for rapid , concurrent genotyping of five common single nucleotide polymorphisms of the brain_derived_neurotrophic_factor -LRB- BDNF -RRB- gene by tetra-primer amplification refractory mutation system .
26796075	0	BDNF	124,128	brain_derived_neurotrophic_factor	89,122	BDNF	brain derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Interaction between different sports branches such as taekwondo , box , athletes and serum brain_derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
22827965	0	BDNF	68,72	dopamine_D5_receptor	29,49	BDNF	dopamine D5 receptor	24225(Tax:10116)	25195(Tax:10116)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	A physiological role for the dopamine_D5_receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex .
21176997	0	BDNF	60,64	dopamine_transporter	9,29	BDNF	dopamine transporter	627	6531	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Striatal dopamine_transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration .
19547753	0	BDNF	0,4	mTOR	15,19	BDNF	mTOR	627	21977(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	BDNF activates mTOR to regulate GluR1 expression required for memory formation .
26279751	0	BDNF	26,30	mTOR	111,115	BDNF	mTOR	24225(Tax:10116)	21977(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY regeneration|nsubj|Effect regeneration|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Effect of laminin-binding BDNF on induction of recurrent laryngeal nerve regeneration by miR-222 activation of mTOR signal pathway .
26279751	0	BDNF	26,30	mTOR	111,115	BDNF	mTOR	24225(Tax:10116)	21977(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY regeneration|nsubj|Effect regeneration|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Effect of laminin-binding BDNF on induction of recurrent laryngeal nerve regeneration by miR-222 activation of mTOR signal pathway .
9322157	0	BDNF	105,109	nerve_growth_factor	29,48	BDNF	nerve growth factor	24225(Tax:10116)	310738(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of the neurotrophins nerve_growth_factor , neurotrophin-3 , and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on neurite growth from adult sensory neurons in compartmented cultures .
10637439	0	BDNF	71,75	p75NTR	36,42	BDNF	p75NTR	627	4804	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Neurotrophin_dependence mediated by p75NTR : contrast between rescue by BDNF and NGF .
16843677	0	BDNF	58,62	p75NTR	72,78	BDNF	p75NTR	627	4804	Gene	Gene	transport|nmod|START_ENTITY bound|nsubj|transport bound|nmod|END_ENTITY	The localization , trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons .
22548193	0	BDNF	47,51	p75NTR	19,25	BDNF	p75NTR	627	4804	Gene	Gene	effects|nmod:poss|START_ENTITY roles|nmod|effects roles|nmod|receptors receptors|amod|END_ENTITY	Divergent roles of p75NTR and Trk receptors in BDNF 's effects on dendritic spine density and morphology .
9728912	0	BDNF	0,4	reelin	15,21	BDNF	reelin	12064(Tax:10090)	19699(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex .
10564362	0	BDNF	36,40	trkB	108,112	BDNF	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY changes|nmod|expression results|nmod|changes results|dep|expression expression|nmod|cells cells|amod|END_ENTITY	Axotomy results in major changes in BDNF expression by dorsal root ganglion cells : BDNF expression in large trkB and trkC cells , in pericellular baskets , and in projections to deep dorsal horn and dorsal column nuclei .
10564362	0	BDNF	83,87	trkB	108,112	BDNF	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Axotomy results in major changes in BDNF expression by dorsal root ganglion cells : BDNF expression in large trkB and trkC cells , in pericellular baskets , and in projections to deep dorsal horn and dorsal column nuclei .
11356095	0	BDNF	19,23	trkB	48,52	BDNF	trkB	397495(Tax:9823)	100519209	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|effect effect|nmod|RNAs RNAs|compound|END_ENTITY	Down-regulation of BDNF mRNA , with no effect on trkB or glucocorticoid receptor m RNAs , in the porcine hippocampus after acute dexamethasone treatment .
11532338	0	BDNF	151,155	trkB	78,82	BDNF	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	brain_derived_neurotrophic_factor|appos|START_ENTITY receptor|nmod|brain_derived_neurotrophic_factor tyrosine_kinase_B|appos|receptor tyrosine_kinase_B|appos|END_ENTITY	Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine_kinase_B -LRB- trkB -RRB- , the high-affinity receptor for brain_derived_neurotrophic_factor -LRB- BDNF -RRB- .
15927371	0	BDNF	0,4	trkB	28,32	BDNF	trkB	396186(Tax:9031)	396157(Tax:9031)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|levels levels|amod|END_ENTITY	BDNF and NT-3 regulation of trkB and trkC mRNA levels in the developing chick spinal cord .
21039416	0	BDNF	120,124	trkB	40,44	BDNF	trkB	627	4915	Gene	Gene	receptor|compound|START_ENTITY study|nmod|receptor agents|nmod|study class|nmod|agents reveals|dobj|class reveals|nsubj|characterization characterization|nmod|antibodies antibodies|compound|END_ENTITY	Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptor .
8000564	0	BDNF	122,126	trkB	25,29	BDNF	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	START_ENTITY|nmod|hybridization hybridization|nmod|mRNA mRNA|amod|END_ENTITY	In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of -LSB- 125I -RSB- BDNF , -LSB- 125I -RSB- NT-4 / 5 and -LSB- 125I -RSB- NT-3 .
8010414	0	BDNF	117,121	trkB	11,15	BDNF	trkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	Pattern|appos|START_ENTITY Pattern|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Pattern of trkB protein-like immunoreactivity in vivo and the in vitro effects of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on developing cochlear and vestibular neurons .
8625822	0	BDNF	47,51	trkB	18,22	BDNF	trkB	396186(Tax:9031)	396157(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo .
9728915	0	BDNF	93,97	trkB	18,22	BDNF	trkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY effects|nmod|responses causes|nmod|effects causes|nsubj|mutation mutation|nmod|END_ENTITY	Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses .
9813329	0	BDNF	126,130	trkB	8,12	BDNF	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY pattern|nmod|expression expression|dep|pattern expression|compound|END_ENTITY	Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat : contrasting pattern with BDNF mRNA expression .
14660651	0	BDP1	84,88	HER2	23,27	BDP1	HER2	55814	2064	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1 .
16542149	0	BDP1	47,51	ZNF297B	24,31	BDP1	ZNF297B	55814	23099	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The zinc finger protein ZNF297B interacts with BDP1 , a subunit of TFIIIB .
20638388	0	BEC1	91,95	gp120	44,49	BEC1	gp120	23416	3700	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1 .
23681223	0	BECN1	0,5	MCL-1	32,37	BECN1	MCL-1	8678	4170	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells .
1905981	0	BEM1	131,135	BUD5	6,10	BEM1	BUD5	852499(Tax:4932)	850405(Tax:4932)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	Yeast BUD5 , encoding a putative GDP-GTP exchange factor , is necessary for bud site selection and interacts with bud formation gene BEM1 .
11294831	0	BENE	0,4	caveolin-1	84,94	BENE	caveolin-1	7851	857	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BENE , a novel raft-associated protein of the MAL proteolipid family , interacts with caveolin-1 in human endothelial-like ECV304 cells .
10673389	0	BERP	0,4	alpha-actinin-4	44,59	BERP	alpha-actinin-4	83616(Tax:10116)	63836(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	BERP , a novel ring finger protein , binds to alpha-actinin-4 .
20139304	0	BES1	53,57	IWS1	12,16	BES1	IWS1	838518(Tax:3702)	840105(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression .
20530484	0	BEST1	105,110	SOX9	0,4	BEST1	SOX9	24115(Tax:10090)	20682(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SOX9 , through interaction with microphthalmia-associated_transcription_factor -LRB- MITF -RRB- and OTX2 , regulates BEST1 expression in the retinal_pigment_epithelium .
25535366	0	BET	44,47	BRD4	69,73	BET	BRD4	92737	23476	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	An in-tumor genetic screen reveals that the BET bromodomain protein , BRD4 , is a potential therapeutic target in ovarian_carcinoma .
26565999	0	BET	0,3	BRDT	12,16	BET	BRDT	92737	676	Gene	Gene	Protein|compound|START_ENTITY END_ENTITY|nsubj|Protein	BET Protein BRDT Complexes with HDAC1 , PRMT5 and TRIM28 and Functions in Transcriptional Repression During Spermatogenesis .
25242322	0	BET	82,85	Brd4	32,36	BET	Brd4	227325(Tax:10090)	57261(Tax:10090)	Gene	Gene	Inhibition|compound|START_ENTITY Toxicities|nmod|Inhibition Identifies|dobj|Toxicities Identifies|nmod|Silencing Silencing|nmod|END_ENTITY	Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition .
8552091	0	BETA2	76,81	BETA3	0,5	BETA2	BETA3	4760	27319	Gene	Gene	genes|compound|START_ENTITY regulator|nmod|genes act|nmod|regulator act|nsubj|END_ENTITY	BETA3 , a novel helix-loop-helix protein , can act as a negative regulator of BETA2 and MyoD-responsive genes .
10636926	0	BETA2	21,26	E2A	51,54	BETA2	E2A	4760	6929	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter .
14726486	0	BETA2	37,42	NeuroD1	29,36	BETA2	NeuroD1	18012(Tax:10090)	18012(Tax:10090)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Tpit-independent function of NeuroD1 -LRB- BETA2 -RRB- in pituitary corticotroph differentiation .
10757813	0	BETA2	49,54	neurogenin_3	67,79	BETA2	neurogenin 3	18012(Tax:10090)	11925(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the pancreatic islet-specific gene BETA2 -LRB- neuroD -RRB- by neurogenin_3 .
9512516	0	BETA2	35,40	p300	56,60	BETA2	p300	18012(Tax:10090)	328572(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells .
12482979	0	BETA2/NeuroD	38,50	secretin	58,66	BETA2/NeuroD	secretin	4760	6343	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB -1 .
14752053	0	BETA2/neuroD	121,133	small_heterodimer_partner	24,49	BETA2/neuroD	small heterodimer partner	4760	8431	Gene	Gene	corepressor|nmod|START_ENTITY END_ENTITY|appos|corepressor	Orphan nuclear receptor small_heterodimer_partner , a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD .
8552091	0	BETA3	0,5	BETA2	76,81	BETA3	BETA2	27319	4760	Gene	Gene	act|nsubj|START_ENTITY act|nmod|regulator regulator|nmod|genes genes|compound|END_ENTITY	BETA3 , a novel helix-loop-helix protein , can act as a negative regulator of BETA2 and MyoD-responsive genes .
1350202	0	BF-1	39,43	HNF-3	65,70	BF-1	HNF-3	24370(Tax:10116)	171302(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|member member|nmod|family family|compound|END_ENTITY	Telencephalon-restricted expression of BF-1 , a new member of the HNF-3 / fork head gene family , in the developing rat brain .
10938097	0	BF-1	0,4	transforming_growth_factor_beta	21,52	BF-1	transforming growth factor beta	2290	7040	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	BF-1 interferes with transforming_growth_factor_beta signaling by associating with Smad partners .
18343828	0	BGLF4	115,120	BMRF1	80,85	BGLF4	BMRF1	3783704(Tax:10376)	17494230	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Effect of phosphorylation on the transactivation activity of Epstein-Barr_virus BMRF1 , a major target of the viral BGLF4 kinase .
25578324	0	BGN	36,39	NOTCH3	76,82	BGN	NOTCH3	633	4854	Gene	Gene	Accumulates|nsubj|START_ENTITY Accumulates|nmod|END_ENTITY	The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3 .
7517208	0	BGP	42,45	biliary_glycoprotein	20,40	BGP	biliary glycoprotein	634	634	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	The N-domain of the biliary_glycoprotein -LRB- BGP -RRB- adhesion molecule mediates homotypic binding : domain interactions and epitope analysis of BGPc .
21459558	0	BGT1	42,46	betaine-GABA_transporter	16,40	BGT1	betaine-GABA transporter	14411(Tax:10090)	14411(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion of the betaine-GABA_transporter -LRB- BGT1 ; slc6a12 -RRB- gene does not affect seizure thresholds of adult mice .
24632712	0	BH3-only	96,104	Bim	114,117	BH3-only	Bim	170770(Tax:10090)	12125(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Deregulated cell death and lymphocyte homeostasis cause premature_lethality in mice lacking the BH3-only proteins Bim and Bmf .
14769940	0	BHD	46,49	Birt-Hogg-Dub	29,42	BHD	Birt-Hogg-Dub	303185(Tax:10116)	303185(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A germ-line insertion in the Birt-Hogg-Dub -LRB- BHD -RRB- gene gives rise to the Nihon rat model of inherited_renal_cancer .
26391953	0	BHLHE40	48,55	TWIST1	24,30	BHLHE40	TWIST1	8553	7291	Gene	Gene	Transcription|nmod|START_ENTITY Transcription|compound|END_ENTITY	Regulation Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells .
22138536	0	BHMT	97,101	betaine-homocysteine_methyltransferase	57,95	BHMT	betaine-homocysteine methyltransferase	635	635	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A splicing variant leads to complete loss of function of betaine-homocysteine_methyltransferase -LRB- BHMT -RRB- gene in hepatocellular_carcinoma .
7665145	0	BHRF-1	88,94	bcl-2	14,19	BHRF-1	bcl-2	3783706(Tax:10376)	596	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|protein protein|amod|END_ENTITY	Expression of bcl-2 protein and transcription of the Epstein-Barr_virus bcl-2 homologue BHRF-1 in Hodgkin 's _ disease : implications for different pathogenic mechanisms .
11373297	0	BHRF1	86,91	Bcl-2	108,113	BHRF1	Bcl-2	3783706(Tax:10376)	596	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , through direct interaction .
16963744	0	BHRF1	75,80	Bcl-2	97,102	BHRF1	Bcl-2	3783706(Tax:10376)	596	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Human cellular protein VRK2 interacts specifically with Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , and enhances cell survival .
8910674	0	BHRF1	28,33	Bcl-2	72,77	BHRF1	Bcl-2	3783706(Tax:10376)	596	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The Epstein-Barr_virus gene BHRF1 , a homologue of the cellular oncogene Bcl-2 , inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs .
11373297	0	BHRF1	86,91	PRA1	21,25	BHRF1	PRA1	3783706(Tax:10376)	10567	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , through direct interaction .
16963744	0	BHRF1	75,80	VRK2	23,27	BHRF1	VRK2	3783706(Tax:10376)	7444	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human cellular protein VRK2 interacts specifically with Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , and enhances cell survival .
14701745	0	BID	37,40	Akt	0,3	BID	Akt	637	207	Gene	Gene	cleavage|compound|START_ENTITY downstream|nmod|cleavage apoptosis|dobj|downstream apoptosis|nsubj|inhibits inhibits|compound|END_ENTITY	Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases .
24074954	0	BID	0,3	BAK	29,32	BID	BAK	637	578	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	BID preferentially activates BAK while BIM preferentially activates BAX , affecting chemotherapy response .
16987815	0	BID	20,23	BAX	94,97	BID	BAX	637	581	Gene	Gene	homology|compound|START_ENTITY sufficient|nsubj|homology sufficient|nmod|activation activation|nmod|END_ENTITY	A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro .
19664589	0	BID	123,126	BAX	94,97	BID	BAX	637	581	Gene	Gene	activated|nmod|START_ENTITY END_ENTITY|acl|activated	Dissimilar mechanisms of cytochrome_c release induced by octyl_glucoside-activated BAX and by BAX activated with truncated BID .
9790773	0	BID	0,3	BCL-2	20,25	BID	BCL-2	12122(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	BID , a proapoptotic BCL-2 family member , is localized to mouse chromosome 6 and human chromosome 22q11 .
18426910	0	BID	22,25	Caspase-2	0,9	BID	Caspase-2	637	835	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress .
11756235	0	BID	80,83	caspase-8	69,78	BID	caspase-8	637	841	Gene	Gene	release|dep|START_ENTITY release|amod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- induces apoptosis through activation of caspase-8 , BID cleavage and cytochrome_c release : its suppression by ectopic expression of Bcl-2 and Bcl-xl .
21072056	0	BID	0,3	caspase-8	18,27	BID	caspase-8	637	841	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|advcl|END_ENTITY	BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane .
12402042	0	BID	0,3	p53	18,21	BID	p53	12122(Tax:10090)	22059(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	BID regulation by p53 contributes to chemosensitivity .
21856084	0	BID	25,28	p53	0,3	BID	p53	637	7157	Gene	Gene	export|compound|START_ENTITY BH3-only|dobj|export BH3-only|nsubj|facilitates facilitates|compound|END_ENTITY	p53 facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response .
12606707	0	BIG1	106,110	FK506-binding_protein_13	15,39	BIG1	FK506-binding protein 13	10565	2286	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Interaction of FK506-binding_protein_13 with brefeldin_A-inhibited_guanine_nucleotide-exchange protein 1 -LRB- BIG1 -RRB- : effects of FK506 .
15705715	0	BIG2	15,19	Exo70	103,108	BIG2	Exo70	10564	23265	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of BIG2 , a brefeldin_A-inhibited guanine_nucleotide-exchange protein , with exocyst protein Exo70 .
10328397	0	BIGH3	40,45	TGFBI	33,38	BIGH3	TGFBI	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A mutation within exon 14 of the TGFBI -LRB- BIGH3 -RRB- gene on chromosome 5q31 causes an asymmetric , late-onset form of lattice corneal_dystrophy .
12770961	0	BIGH3	40,45	TGFBI	33,38	BIGH3	TGFBI	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	H626R and R124C mutations of the TGFBI -LRB- BIGH3 -RRB- gene caused lattice_corneal_dystrophy in Vietnamese people .
14597039	0	BIGH3	56,61	TGFBI	49,54	BIGH3	TGFBI	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new mutation -LRB- Leu569Arg -RRB- within exon 13 of the TGFBI -LRB- BIGH3 -RRB- gene causes lattice corneal_dystrophy type I. PURPOSE : To describe an American family with lattice corneal_dystrophy type I , which associates with a novel mutation , Leu569Arg , of the TGFBI -LRB- BIGH3 -RRB- gene .
15111592	0	BIGH3	28,33	TGFBI	21,26	BIGH3	TGFBI	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Two mutations in the TGFBI -LRB- BIGH3 -RRB- gene associated with lattice_corneal_dystrophy in an extensively studied family .
18470323	0	BIGH3	92,97	TGFBI	85,90	BIGH3	TGFBI	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Anticipation in familial lattice corneal_dystrophy type I with R124C mutation in the TGFBI -LRB- BIGH3 -RRB- gene .
24589966	0	BIGH3	123,128	TGFBI	116,121	BIGH3	TGFBI	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lattice Corneal_Dystrophy : a report of two cases in twin sisters due to 3 mutations -LRB- T1620C , C1416T , A1924G -RRB- in the TGFBI -LRB- BIGH3 -RRB- gene .
15177960	0	BIGH3	116,121	transforming_growth_factor_beta-induced	75,114	BIGH3	transforming growth factor beta-induced	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphic corneal_amyloidosis : a disorder due to a novel mutation in the transforming_growth_factor_beta-induced -LRB- BIGH3 -RRB- gene .
19632297	0	BIK	52,55	Bcl2-interacting_killer	27,50	BIK	Bcl2-interacting killer	638	638	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between the Bcl2-interacting_killer -LRB- BIK -RRB- gene and schizophrenia .
19555760	0	BIM	15,18	BDNF	0,4	BIM	BDNF	10018	627	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	BDNF regulates BIM expression levels in 3-nitropropionic_acid-treated cortical neurons .
18830673	0	BIM1	0,4	DORNROSCHEN	124,135	BIM1	DORNROSCHEN	830708(Tax:3702)	837856(Tax:3702)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	BIM1 , a bHLH protein involved in brassinosteroid signalling , controls Arabidopsis embryonic patterning via interaction with DORNROSCHEN and DORNROSCHEN-LIKE .
11554924	0	BIM1	134,138	EB1	119,122	BIM1	EB1	856736(Tax:4932)	22919	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	PKC1 , a protein kinase C homologue of Saccharomyces_cerevisiae , participates in microtubule function through the yeast EB1 homologue , BIM1 .
19629135	0	BIN1	52,56	E2F1	89,93	BIN1	E2F1	274	1869	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage .
22281836	0	BIN1	43,47	bridging_integrator_1	20,41	BIN1	bridging integrator 1	274	274	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of bridging_integrator_1 -LRB- BIN1 -RRB- as a potential tumor suppressor and prognostic marker in hepatocellular_carcinoma .
15522178	0	BIN1	87,91	bridging_integrator_protein-1	56,85	BIN1	bridging integrator protein-1	274	274	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Expression of estrogen_sulfotransferase -LRB- EST -RRB- gene and bridging_integrator_protein-1 -LRB- BIN1 -RRB- gene and their significance in breast tissues -RSB- .
21447800	0	BIN1	17,21	c-MYC	0,5	BIN1	c-MYC	274	4609	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	c-MYC suppresses BIN1 to release poly -LRB- ADP-ribose -RRB- _ polymerase_1 : a mechanism by which cancer cells acquire cisplatin resistance .
12114546	0	BIN2	21,25	BZR1	58,62	BIN2	BZR1	827605(Tax:3702)	843845(Tax:3702)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1 , a positive regulator of the brassinosteroid signaling pathway in Arabidopsis .
23169658	0	BIN2	41,45	MYBL2	0,5	BIN2	MYBL2	827605(Tax:3702)	843443(Tax:3702)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	MYBL2 is a substrate of GSK3-like kinase BIN2 and acts as a corepressor of BES1 in brassinosteroid signaling pathway in Arabidopsis .
23624714	0	BINDING_PROTEIN	0,15	bZIP28	92,98	BINDING PROTEIN	bZIP28	834207(Tax:3702)	820249(Tax:3702)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	BINDING_PROTEIN is a master regulator of the endoplasmic reticulum stress sensor/transducer bZIP28 in Arabidopsis .
17698078	0	BIR1	25,29	XIAP	40,44	BIR1	XIAP	3763	331	Gene	Gene	domain|compound|START_ENTITY structure|nmod|domain structure|nmod|END_ENTITY	Crystal structure of the BIR1 domain of XIAP in two crystal forms .
26815504	0	BIRC3	100,105	baculoviral_IAP_repeat-containing_3	63,98	BIRC3	baculoviral IAP repeat-containing 3	330	330	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral_IAP_repeat-containing_3 -LRB- BIRC3 -RRB- gene in pancreatic_cancer cells .
25633199	0	BIRC3	44,49	cREL	69,73	BIRC3	cREL	330	5966	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival .
18789152	0	BIRC5	130,135	MCL-1	138,143	BIRC5	MCL-1	332	4170	Gene	Gene	survivin|appos|START_ENTITY survivin|amod|END_ENTITY	Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans_retinoic_acid -LRB- ATRA -RRB- through downregulation of survivin -LRB- BIRC5 -RRB- , MCL-1 and LTbeta-R in hormone - and drug resistant_prostate_cancer cell line , DU-145 .
23433354	0	BIRC5	15,20	OCT4	0,4	BIRC5	OCT4	332	5460	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular_carcinoma .
23232114	0	BIRC5	47,52	miR-335	23,30	BIRC5	miR-335	332	442904	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Genetic variation in a miR-335 binding site in BIRC5 alters susceptibility to lung_cancer in Chinese Han populations .
21471707	0	BK_channel	90,100	Bax	50,53	BK channel	Bax	83731(Tax:10116)	24887(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Activation of the permeability transition pore by Bax via inhibition of the mitochondrial BK_channel .
23762954	0	BLA	31,34	Beta-lactamase	15,29	BLA	Beta-lactamase	4290808(Tax:287)	4290808(Tax:287)	Gene	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	ML302 , a Novel Beta-lactamase -LRB- BLA -RRB- Inhibitor VIM-2 and IMP-1 are Ambler class B metallo-b-lactamases -LRB- MBL -RRB- capable of hydrolyzing a broad-spectrum of b-lactam antibiotics .
2428624	0	BLAST-2	26,33	p45	21,24	BLAST-2	p45	2208	4778	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Ligation of the CD23 , p45 -LRB- BLAST-2 , EBVCS -RRB- antigen triggers the cell-cycle progression of activated B lymphocytes .
22593617	0	BLIMP1	67,73	PAX5	82,86	BLIMP1	PAX5	639	5079	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	B cell receptor-ERK1 / 2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation : a mechanism of antigen-triggering plasma cell differentiation .
16849320	0	BLIMP1	118,124	viperin	46,53	BLIMP1	viperin	639	91543	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Toll-like receptor-dependent and - independent viperin gene expression and counter-regulation by PRDI-binding_factor-1 / BLIMP1 .
12406557	0	BLK	47,50	DAM1	6,10	BLK	DAM1	12143(Tax:10090)	17145(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells .
24239288	0	BLM	16,19	TopBP1	0,6	BLM	TopBP1	641	11073	Gene	Gene	level|compound|START_ENTITY controls|dobj|level controls|nsubj|END_ENTITY	TopBP1 controls BLM protein level to maintain genome stability .
24968003	0	BLMP-1	0,6	Blimp-1	7,14	BLMP-1	Blimp-1	172917(Tax:6239)	639	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	BLMP-1 / Blimp-1 regulates the spatiotemporal cell migration pattern in C. _ elegans .
10583957	0	BLNK	39,43	B_cell_linker_protein	16,37	BLNK	B cell linker protein	17060(Tax:10090)	17060(Tax:10090)	Gene	Gene	Requirement|appos|START_ENTITY Requirement|nmod|END_ENTITY	Requirement for B_cell_linker_protein -LRB- BLNK -RRB- in B cell development .
19218240	0	BLNK	0,4	H-Ras	18,23	BLNK	H-Ras	29760	3265	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation .
25870107	0	BLOC1S1	12,19	IRE1	28,32	BLOC1S1	IRE1	2647	2081	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Cleavage of BLOC1S1 mRNA by IRE1 is sequence-specific , temporally separate from XBP1 splicing , and dispensable for cell viability under acute ER-stress .
15102850	0	BLOS1	51,56	snapin	18,24	BLOS1	snapin	14533(Tax:10090)	20615(Tax:10090)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of snapin and three novel proteins -LRB- BLOS1 , BLOS2 , and BLOS3/reduced pigmentation -RRB- as subunits of biogenesis_of_lysosome-related_organelles_complex-1 -LRB- BLOC-1 -RRB- .
9780317	0	BLT-1	141,146	insulin-like_growth_factor-I	62,90	BLT-1	insulin-like growth factor-I	16995(Tax:10090)	16000(Tax:10090)	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Regulation of luteinizing_hormone_receptor gene expression by insulin-like_growth_factor-I in an immortalized murine Leydig tumor cell line -LRB- BLT-1 -RRB- It is postulated that insulin-like_growth_factor-I -LRB- IGF-I -RRB- , a 70-amino_acid mitogenic polypeptide , regulates Leydig cell steroidogenesis .
22349239	0	BLU	17,20	sMEK1	56,61	BLU	sMEK1	51364	55671	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Tumor suppressor BLU enhances pro-apoptotic activity of sMEK1 through physical interaction .
7656592	0	BLVRB	67,72	biliverdin-IX_beta_reductase	32,60	BLVRB	biliverdin-IX beta reductase	645	645	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the newly identified biliverdin-IX_beta_reductase gene -LRB- BLVRB -RRB- to human chromosome 19q13 .13 -- > q13 .2 by fluorescence in situ hybridization .
11056056	0	BLZF1	35,40	JEM-1	28,33	BLZF1	JEM-1	8548	8548	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the JEM-1 -LRB- BLZF1 -RRB- gene on human chromosome 1q24 : molecular cloning and analysis of its promoter region .
18155301	0	BLyS	71,75	B-cell-activating_factor	14,38	BLyS	B-cell-activating factor	10673	10673	Gene	Gene	expression|compound|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of B-cell-activating_factor -LRB- BAFF -RRB- / B_lymphocyte_stimulator -LRB- BLyS -RRB- expression in human neutrophils .
15095277	0	BLyS	20,24	BAFF	14,18	BLyS	BAFF	10673	10673	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of BAFF -LRB- BLyS -RRB- in T cells infiltrating labial salivary glands from patients with Sj gren 's syndrome .
15944757	0	BLyS	94,98	BCMA	123,127	BLyS	BCMA	24099(Tax:10090)	21935(Tax:10090)	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Generation and characterization of C305 , a murine neutralizing scFv antibody that can inhibit BLyS binding to its receptor BCMA .
12192248	0	BLyS	62,66	B_lymphocyte_stimulator	68,91	BLyS	B lymphocyte stimulator	10673	10673	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Systemic_lupus_erythematosus : a blissless disease of too much BLyS -LRB- B_lymphocyte_stimulator -RRB- protein .
14597212	0	BLyS	105,109	B_lymphocyte_stimulator	80,103	BLyS	B lymphocyte stimulator	10673	10673	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	B lymphocytes from individuals with common_variable_immunodeficiency respond to B_lymphocyte_stimulator -LRB- BLyS protein -RRB- in vitro .
18155301	0	BLyS	71,75	B_lymphocyte_stimulator	46,69	BLyS	B lymphocyte stimulator	10673	10673	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulation of B-cell-activating_factor -LRB- BAFF -RRB- / B_lymphocyte_stimulator -LRB- BLyS -RRB- expression in human neutrophils .
19411764	0	BLyS	37,41	B_lymphocyte_stimulator	12,35	BLyS	B lymphocyte stimulator	10673	10673	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of B_lymphocyte_stimulator -LRB- BLyS -RRB- in systemic_lupus_erythematosus .
21883351	0	BLyS	58,62	B_lymphocyte_stimulator	28,51	BLyS	B lymphocyte stimulator	10673	10673	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Promoter -817 C > T variant of B_lymphocyte_stimulator gene -LRB- BLyS -RRB- and susceptibility to endometriosis-related_infertility and idiopathic infertility in Brazilian population .
12594954	0	BLyS	99,103	TACI	77,81	BLyS	TACI	24099(Tax:10090)	57916(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Loss of TACI causes fatal lymphoproliferation and autoimmunity , establishing TACI as an inhibitory BLyS receptor .
12594954	0	BLyS	99,103	TACI	8,12	BLyS	TACI	24099(Tax:10090)	57916(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY TACI|nmod|receptor establishing|dobj|TACI causes|advcl|establishing causes|nsubj|Loss Loss|nmod|END_ENTITY	Loss of TACI causes fatal lymphoproliferation and autoimmunity , establishing TACI as an inhibitory BLyS receptor .
25162001	0	BLyS	22,26	TACI	14,18	BLyS	TACI	10673	23495	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Serum soluble TACI , a BLyS receptor , is a powerful prognostic marker of outcome in chronic_lymphocytic_leukemia .
10715587	0	BM88_antigen	24,36	P19	72,75	BM88 antigen	P19	57754(Tax:10090)	83430(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Early expression of the BM88_antigen during neuronal differentiation of P19 embryonal_carcinoma cells .
15828232	0	BMAL1	114,119	CLOCK	107,112	BMAL1	CLOCK	406	9575	Gene	Gene	Hyperlipidemia|dep|START_ENTITY Hyperlipidemia|dep|regulation regulation|nmod|gene gene|nmod|END_ENTITY	-LSB- Hyperlipidemia and peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- -- regulation of the PPARalpha gene by CLOCK : BMAL1 -RSB- .
16628007	0	BMAL1	72,77	CLOCK	59,64	BMAL1	CLOCK	406	9575	Gene	Gene	complex|nummod|START_ENTITY regulation|dep|complex regulation|nmod|END_ENTITY	Post-translational regulation of circadian transcriptional CLOCK -LRB- NPAS2 -RRB- / BMAL1 complex by CRYPTOCHROMES .
23580255	0	BMAL1	101,106	CLOCK	95,100	BMAL1	CLOCK	11865(Tax:10090)	9575	Gene	Gene	complex|nummod|START_ENTITY nature|dep|complex nature|nmod|DNA-binding DNA-binding|nmod|END_ENTITY	Usf1 , a suppressor of the circadian Clock mutant , reveals the nature of the DNA-binding of the CLOCK : BMAL1 complex in mice .
24395244	0	BMAL1	6,11	CLOCK	0,5	BMAL1	CLOCK	406	9575	Gene	Gene	factor|nsubj|START_ENTITY END_ENTITY|parataxis|factor	CLOCK : BMAL1 is a pioneer-like transcription factor .
25228643	0	BMAL1	20,25	CLOCK	14,19	BMAL1	CLOCK	406	9575	Gene	Gene	inhibition|nummod|START_ENTITY modes|dep|inhibition modes|nmod|END_ENTITY	Dual modes of CLOCK : BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock .
10652231	0	BMAL1	23,28	Clock	48,53	BMAL1	Clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY expression|nmod|mRNA altered|nsubjpass|expression altered|nmod|mice mice|amod|END_ENTITY	Rhythmic expression of BMAL1 mRNA is altered in Clock mutant mice : differential regulation in the suprachiasmatic nucleus and peripheral tissues .
23580255	0	BMAL1	101,106	Clock	36,41	BMAL1	Clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	complex|nummod|START_ENTITY nature|dep|complex reveals|dobj|nature reveals|nsubj|Usf1 Usf1|appos|suppressor suppressor|nmod|mutant mutant|compound|END_ENTITY	Usf1 , a suppressor of the circadian Clock mutant , reveals the nature of the DNA-binding of the CLOCK : BMAL1 complex in mice .
26562092	0	BMAL1	31,36	Clock	88,93	BMAL1	Clock	406	9575	Gene	Gene	Phosphorylation|compound|START_ENTITY CK2-Mediated|dobj|Phosphorylation CK2-Mediated|xcomp|Control Control|dobj|END_ENTITY	CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock .
9735336	0	BMAL1	25,30	Clock	68,73	BMAL1	Clock	406	9575	Gene	Gene	oscillation|nmod|START_ENTITY oscillation|appos|partner partner|nmod|END_ENTITY	Circadian oscillation of BMAL1 , a partner of a mammalian clock gene Clock , in rat suprachiasmatic nucleus .
9875535	0	BMAL1	45,50	Clock	97,102	BMAL1	Clock	406	9575	Gene	Gene	expression|compound|START_ENTITY rhythm|nmod|expression rhythm|appos|partner partner|nmod|END_ENTITY	Circadian rhythm and light responsiveness of BMAL1 expression , a partner of mammalian clock gene Clock , in the suprachiasmatic nucleus of rats .
25182847	0	BMAL1	54,59	MAN1	25,29	BMAL1	MAN1	406	23592	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Nuclear envelope protein MAN1 regulates clock through BMAL1 .
18430226	0	BMAL1	58,63	PER2	40,44	BMAL1	PER2	406	8864	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK .
12738229	0	BMAL1	91,96	clock	46,51	BMAL1	clock	406	9575	Gene	Gene	activation|nmod|START_ENTITY Regulation|dep|activation Regulation|nmod|promoter promoter|nmod|components components|compound|END_ENTITY	Regulation of the PAI-1 promoter by circadian clock components : differential activation by BMAL1 and BMAL2 .
15523558	0	BMAL1	0,5	clock	59,64	BMAL1	clock	406	9575	Gene	Gene	START_ENTITY|appos|components components|nmod|END_ENTITY	BMAL1 and CLOCK , two essential components of the circadian clock , are involved in glucose homeostasis .
16109848	0	BMAL1	42,47	clock	10,15	BMAL1	clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	SUMOylation|nmod|START_ENTITY control|nmod|SUMOylation control|nsubj|END_ENTITY	Circadian clock control by SUMOylation of BMAL1 .
16847346	0	BMAL1	61,66	clock	103,108	BMAL1	clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	START_ENTITY|appos|componentof componentof|dep|END_ENTITY	Early aging and age-related pathologies in mice deficient in BMAL1 , the core componentof the circadian clock .
18430226	0	BMAL1	58,63	clock	25,30	BMAL1	clock	406	9575	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|PER2 PER2|compound|END_ENTITY	Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK .
22249125	0	BMAL1	151,156	clock	136,141	BMAL1	clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein , BMAL1 .
22249125	0	BMAL1	151,156	clock	37,42	BMAL1	clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY upregulation|nmod|protein drug|nmod|upregulation toxicity|nmod|drug protects|nmod|toxicity modulator|acl:relcl|protects modulator|nmod|END_ENTITY	Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein , BMAL1 .
25228643	0	BMAL1	20,25	clock	109,114	BMAL1	clock	406	9575	Gene	Gene	inhibition|nummod|START_ENTITY inhibition|acl|mediated mediated|nmod|END_ENTITY	Dual modes of CLOCK : BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock .
25961797	0	BMAL1	83,88	clock	39,44	BMAL1	clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	terminus|compound|START_ENTITY interactions|nmod|terminus regulates|nmod|interactions regulates|dobj|END_ENTITY	Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus .
9735336	0	BMAL1	25,30	clock	57,62	BMAL1	clock	406	9575	Gene	Gene	oscillation|nmod|START_ENTITY oscillation|appos|partner partner|nmod|Clock Clock|compound|END_ENTITY	Circadian oscillation of BMAL1 , a partner of a mammalian clock gene Clock , in rat suprachiasmatic nucleus .
9875535	0	BMAL1	45,50	clock	86,91	BMAL1	clock	406	9575	Gene	Gene	expression|compound|START_ENTITY rhythm|nmod|expression rhythm|appos|partner partner|nmod|Clock Clock|compound|END_ENTITY	Circadian rhythm and light responsiveness of BMAL1 expression , a partner of mammalian clock gene Clock , in the suprachiasmatic nucleus of rats .
24847962	0	BMAL2	28,33	ARNTL2	20,26	BMAL2	ARNTL2	56938	56938	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The polymorphism of ARNTL2 -LRB- BMAL2 -RRB- gene rs2306074 C > T is associated with susceptibility of Alzheimer_disease in Chinese population .
26497775	0	BMAL2	54,59	brain-muscle-ARNT-like_protein-2	20,52	BMAL2	brain-muscle-ARNT-like protein-2	56938	56938	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between brain-muscle-ARNT-like_protein-2 -LRB- BMAL2 -RRB- gene polymorphism and type 2 diabetes_mellitus in obese Japanese individuals : A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study .
25611382	0	BMCC1	0,5	AKT	59,62	BMCC1	AKT	158471	207	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|activity activity|compound|END_ENTITY	BMCC1 , which is an interacting partner of BCL2 , attenuates AKT activity , accompanied by apoptosis .
21052002	0	BMI-1	42,47	c-Myc	49,54	BMI-1	c-Myc	648	4609	Gene	Gene	p14ARF|compound|START_ENTITY p14ARF|dep|END_ENTITY	Implication of USP22 in the regulation of BMI-1 , c-Myc , p16INK4a , p14ARF , and cyclin_D2 expression in primary colorectal_carcinomas .
22982443	0	BMI-1	86,91	miR-200c	0,8	BMI-1	miR-200c	648	406985	Gene	Gene	down-regulation|nmod|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	miR-200c inhibits melanoma_progression and drug resistance through down-regulation of BMI-1 .
25367080	0	BMI-1	107,112	miR-200c	0,8	BMI-1	miR-200c	648	406985	Gene	Gene	down-regulation|nmod|START_ENTITY Inhibits|nmod|down-regulation Inhibits|nsubj|END_ENTITY	miR-200c Inhibits invasion , migration and proliferation of bladder_cancer cells through down-regulation of BMI-1 and E2F3 .
21052002	0	BMI-1	42,47	p16INK4a	56,64	BMI-1	p16INK4a	648	1029	Gene	Gene	p14ARF|compound|START_ENTITY p14ARF|dep|END_ENTITY	Implication of USP22 in the regulation of BMI-1 , c-Myc , p16INK4a , p14ARF , and cyclin_D2 expression in primary colorectal_carcinomas .
19556423	0	BMI1	14,18	CD34	48,52	BMI1	CD34	648	947	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Repression of BMI1 in normal and leukemic human CD34 -LRB- + -RRB- cells impairs self-renewal and induces apoptosis .
20724541	0	BMI1	0,4	CD34	67,71	BMI1	CD34	648	947	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|advcl|BCR-ABL BCR-ABL|nmod|transformation transformation|nmod|cells cells|compound|END_ENTITY	BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34 + cells .
22120721	0	BMI1	32,36	Cyclin_E1	0,9	BMI1	Cyclin E1	648	898	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cyclin_E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression .
16582100	0	BMI1	0,4	E2F-1	25,30	BMI1	E2F-1	648	1869	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas .
19543317	0	BMI1	0,4	H-RAS	21,26	BMI1	H-RAS	648	3265	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	BMI1 cooperates with H-RAS to induce an aggressive breast_cancer phenotype with brain metastases .
25726526	0	BMI1	57,61	c_oxidase_subunit_4	27,46	BMI1	c oxidase subunit 4	648	1327	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nuclear-encoded cytochrome c_oxidase_subunit_4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas .
25505268	0	BMI1	53,57	miR-200c	80,88	BMI1	miR-200c	648	406985	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|cluster cluster|amod|END_ENTITY	PLK1 inhibition downregulates polycomb group protein BMI1 via modulation of the miR-200c / 141 cluster .
27105531	0	BMI1	72,76	miR-200c	2,10	BMI1	miR-200c	648	406985	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity END_ENTITY|parataxis|regulates	A miR-200c / 141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells .
25475727	0	BMI1	100,104	miR-203	0,7	BMI1	miR-203	648	406986	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1 .
12091247	0	BMK1	0,4	SPRR1B	54,60	BMK1	SPRR1B	5598	6699	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	BMK1 -LRB- ERK5 -RRB- regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells .
22869143	0	BMK1	0,4	p53	38,41	BMK1	p53	5598	7157	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction .
22500623	0	BMP	54,57	BDNF	34,38	BMP	BDNF	649	627	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Axonally translated SMADs link up BDNF and retrograde BMP signaling .
19597895	0	BMP	43,46	BMP-7	25,30	BMP	BMP-7	649	655	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion : a pilot study .
19733164	0	BMP	11,14	Bmpr1a	26,32	BMP	Bmpr1a	649	657	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	The type I BMP receptors , Bmpr1a and Acvr1 , activate multiple signaling pathways to regulate lens formation .
25453556	0	BMP	73,76	Crimpy	0,6	BMP	Crimpy	37778(Tax:7227)	40288(Tax:7227)	Gene	Gene	Discrimination|nmod|START_ENTITY Discrimination|compound|END_ENTITY	Crimpy Enables Discrimination of Presynaptic and Postsynaptic Pools of a BMP at the Drosophila Neuromuscular Junction .
18539121	0	BMP	105,108	Crossveinless_2	24,39	BMP	Crossveinless 2	33432(Tax:7227)	45280(Tax:7227)	Gene	Gene	modulator|nmod|START_ENTITY modulator|nsubj|END_ENTITY	The BMP-binding protein Crossveinless_2 is a short-range , concentration-dependent , biphasic modulator of BMP signaling in Drosophila .
22469980	0	BMP	41,44	Death_inducer-obliterator_1	0,27	BMP	Death inducer-obliterator 1	649	11083	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Death_inducer-obliterator_1 -LRB- Dido1 -RRB- is a BMP target gene and promotes BMP-induced melanoma progression .
25330173	0	BMP	0,3	EGFR	42,46	BMP	EGFR	649	1956	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	BMP Signaling in Astrocytes Downregulates EGFR to Modulate Survival and Maturation .
16339188	0	BMP	8,11	GDF3	0,4	BMP	GDF3	649	9573	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	GDF3 , a BMP inhibitor , regulates cell fate in stem cells and early embryos .
18823971	0	BMP	10,13	GDF3	0,4	BMP	GDF3	649	9573	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nsubj|END_ENTITY	GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses .
26095393	0	BMP	31,34	GSK3b	14,19	BMP	GSK3b	649	2932	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Inhibition of GSK3b Stimulates BMP Signaling and Decreases SOST Expression Which Results in Enhanced Osteoblast Differentiation .
21750037	0	BMP	20,23	Gbb	32,35	BMP	Gbb	37778(Tax:7227)	37778(Tax:7227)	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction .
24099773	0	BMP	54,57	Grg4	20,24	BMP	Grg4	649	7091	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling .
15538389	0	BMP	38,41	LIMK1	14,19	BMP	LIMK1	649	3984	Gene	Gene	binding|nmod|START_ENTITY receptor|amod|binding END_ENTITY|nmod|receptor	Activation of LIMK1 by binding to the BMP receptor , BMPRII , regulates BMP-dependent dendritogenesis .
20036230	0	BMP	51,54	MAN1	34,38	BMP	MAN1	33432(Tax:7227)	37838(Tax:7227)	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins .
21743293	0	BMP	95,98	MiRNA-20a	0,9	BMP	MiRNA-20a	649	406982	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling .
19339557	0	BMP	15,18	PP2A	0,4	BMP	PP2A	649	5524	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1 .
19339557	0	BMP	50,53	PP2A	0,4	BMP	PP2A	649	5524	Gene	Gene	complexes|compound|START_ENTITY interacting|nmod|complexes signalling|dep|interacting BMP|acl|signalling regulates|dobj|BMP regulates|nsubj|END_ENTITY	PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1 .
18059158	0	BMP	0,3	PTEN	15,19	BMP	PTEN	649	5728	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	BMP suppresses PTEN expression via RAS/ERK signaling .
23153495	0	BMP	69,72	Sox2	0,4	BMP	Sox2	649	6657	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Sox2 in the dermal_papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors .
19536134	0	BMP	34,37	TAK1	0,4	BMP	TAK1	649	26409(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	TAK1 is an essential regulator of BMP signalling in cartilage .
22895257	0	BMP	35,38	apelin	14,20	BMP	apelin	649	8862	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of apelin expression by BMP signaling in endothelial cells .
11321800	0	BMP	97,100	bone_morphogenetic_protein	69,95	BMP	bone morphogenetic protein	649	649	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Experimental study of secondary bone graft of alveolar_clefts using bone_morphogenetic_protein -LRB- BMP -RRB- -RSB- .
15192043	0	BMP	52,55	bone_morphogenetic_protein	24,50	BMP	bone morphogenetic protein	649	649	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Characterization of the bone_morphogenetic_protein -LRB- BMP -RRB- system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary_pulmonary_hypertension : roles of BMP type IB receptor -LRB- activin receptor-like kinase-6 -RRB- in the mitotic action .
15775299	0	BMP	53,56	bone_morphogenetic_protein	25,51	BMP	bone morphogenetic protein	649	649	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Bone regeneration using bone_morphogenetic_protein -LRB- BMP -RRB- -RSB- .
17472960	0	BMP	83,86	bone_morphogenetic_protein	55,81	BMP	bone morphogenetic protein	649	649	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Repulsive guidance molecule RGMa alters utilization of bone_morphogenetic_protein -LRB- BMP -RRB- type II receptors by BMP2 and BMP4 .
2060214	0	BMP	40,43	bone_morphogenetic_protein	12,38	BMP	bone morphogenetic protein	649	649	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of bone_morphogenetic_protein -LRB- BMP -RRB- derived from human and bovine bone matrix .
2195159	0	BMP	60,63	bone_morphogenetic_protein	32,58	BMP	bone morphogenetic protein	649	649	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Immunohistochemical analysis of bone_morphogenetic_protein -LRB- BMP -RRB- in osteosarcoma .
22961979	0	BMP	96,99	bone_morphogenetic_protein	68,94	BMP	bone morphogenetic protein	649	649	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	SMAD versus non-SMAD signaling is determined by lateral mobility of bone_morphogenetic_protein -LRB- BMP -RRB- receptors .
25506972	0	BMP	80,83	bone_morphogenetic_protein	43,69	BMP	bone morphogenetic protein	649	649	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Development of a potent and ALK2 selective bone_morphogenetic_protein receptor -LRB- BMP -RRB- inhibitor A fast-track chemistry effort was initiated to evaluate the structure-activity relationship of the 3 - and 6-positions of the pyrazolo -LSB- 1,5-a -RSB- pyrimidine scaffold of the known bone_morphogenetic_protein -LRB- BMP -RRB- inhibitors .
7530996	0	BMP	62,65	bone_morphogenetic_protein	34,60	BMP	bone morphogenetic protein	649	649	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Immunohistochemical evaluation of bone_morphogenetic_protein -LRB- BMP -RRB- in mixed_tumor of skin .
8301605	0	BMP	64,67	bone_morphogenetic_protein	36,62	BMP	bone morphogenetic protein	649	649	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of bone_morphogenetic_protein -LRB- BMP -RRB- in calcifying fibrous_epulis .
8935072	0	BMP	52,55	bone_morphogenetic_protein	24,50	BMP	bone morphogenetic protein	649	649	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The inductive effect of bone_morphogenetic_protein -LRB- BMP -RRB- on human periodontal fibroblast-like cells in vitro .
23639540	0	BMP	109,112	bone_morphogenetic_protein_receptor	72,107	BMP	bone morphogenetic protein receptor	649	649	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Synthesis and structure-activity relationships of a novel and selective bone_morphogenetic_protein_receptor -LRB- BMP -RRB- inhibitor derived from the pyrazolo -LSB- 1.5-a -RSB- pyrimidine scaffold of dorsomorphin : the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe .
24448807	0	BMP	86,89	p50	164,167	BMP	p50	649	4790	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Transcriptional repression of the transforming_growth_factor_b -LRB- TGF-b -RRB- Pseudoreceptor BMP and activin membrane-bound inhibitor -LRB- BAMBI -RRB- by Nuclear Factor kB -LRB- NF-kB -RRB- p50 enhances TGF-b signaling in hepatic stellate cells .
17220882	0	BMP	31,34	spichthyin	11,21	BMP	spichthyin	33432(Tax:7227)	34681(Tax:7227)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules .
16226436	0	BMP	60,63	syndecan-3	40,50	BMP	syndecan-3	649	9672	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation .
20708591	0	BMP	44,47	type_IV_collagen	18,34	BMP	type IV collagen	33432(Tax:7227)	33727(Tax:7227)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Hemocyte-secreted type_IV_collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila .
10704876	0	BMP-1	20,25	Tolloid	26,33	BMP-1	Tolloid	414883(Tax:9031)	414883(Tax:9031)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of chick BMP-1 / Tolloid during patterning of the neural tube and somites .
14671324	0	BMP-1	38,43	myostatin	21,30	BMP-1	myostatin	12153(Tax:10090)	17700(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of latent myostatin by the BMP-1 / tolloid family of metalloproteinases .
11741284	0	BMP-15	63,69	Follistatin	0,11	BMP-15	Follistatin	59302(Tax:10116)	24373(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Follistatin inhibits the function of the oocyte-derived factor BMP-15 .
17453295	0	BMP-15	75,81	growth_differentiation_factor-9	12,43	BMP-15	growth differentiation factor-9	9210	2661	Gene	Gene	role|amod|START_ENTITY role|nmod|END_ENTITY	The role of growth_differentiation_factor-9 -LRB- GDF-9 -RRB- and its analog , GDF-9b / BMP-15 , in human breast_cancer .
10633078	0	BMP-2	0,5	ALK3	6,10	BMP-2	ALK3	12156(Tax:10090)	12166(Tax:10090)	Gene	Gene	START_ENTITY|appos|signal signal|nsubj|END_ENTITY	BMP-2 / ALK3 and HGF signal in parallel to regulate renal collecting duct morphogenesis .
20432444	0	BMP-2	22,27	Adiponectin	0,11	BMP-2	Adiponectin	650	9370	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Adiponectin increases BMP-2 expression in osteoblasts via AdipoR receptor signaling pathway .
23825702	0	BMP-2	0,5	Alx3	28,32	BMP-2	Alx3	12156(Tax:10090)	11694(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation .
19021035	0	BMP-2	0,5	BMP-4	10,15	BMP-2	BMP-4	650	652	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts : Smad signaling , not alkaline_phosphatase activity , predicts rescue of mineralization .
18458495	0	BMP-2	10,15	BMP-7	60,65	BMP-2	BMP-7	650	655	Gene	Gene	homodimers|compound|START_ENTITY Effect|nmod|homodimers Effect|parataxis|homodimers homodimers|nsubj|END_ENTITY	Effect of BMP-2 and BMP-7 homodimers and a mixture of BMP-2 / BMP-7 homodimers on osteoblast adhesion and growth following culture on a collagen scaffold .
19361857	0	BMP-2	30,35	BMP-7	36,41	BMP-2	BMP-7	29373(Tax:10116)	85272(Tax:10116)	Gene	Gene	Incorporation|nmod|START_ENTITY Incorporation|dep|system system|compound|END_ENTITY	Incorporation of a sequential BMP-2 / BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering .
19585564	0	BMP-2	11,16	BMP-7	17,22	BMP-2	BMP-7	29373(Tax:10116)	85272(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|nanocapsules nanocapsules|nsubj|delivery delivery|compound|END_ENTITY	Sequential BMP-2 / BMP-7 delivery from polyester nanocapsules .
9102298	0	BMP-2	8,13	BMP-7	24,29	BMP-2	BMP-7	378779(Tax:9031)	395494(Tax:9031)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of BMP-2 and OP-1 -LRB- BMP-7 -RRB- in programmed cell death and skeletogenesis during chick limb development .
19639633	0	BMP-2	72,77	BMP-binding_peptide	20,39	BMP-2	BMP-binding peptide	650	25907	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|effects effects|nmod|END_ENTITY	Enhanced effects of BMP-binding_peptide combined with recombinant human BMP-2 on the healing of a rodent_segmental_femoral_defect .
23708553	0	BMP-2	43,48	Calcitonin_gene-related_peptide	0,31	BMP-2	Calcitonin gene-related peptide	650	796	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Calcitonin_gene-related_peptide stimulates BMP-2 expression and the differentiation of human osteoblast-like cells in vitro .
21121067	0	BMP-2	165,170	Cbfa-1	171,177	BMP-2	Cbfa-1	650	860	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2 / Cbfa-1 pathway .
8674421	0	BMP-2	48,53	Fgf-4	14,19	BMP-2	Fgf-4	378779(Tax:9031)	428857(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb .
22855527	0	BMP-2	47,52	GATA-6	0,6	BMP-2	GATA-6	12156(Tax:10090)	14465(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|nsubj|END_ENTITY	GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation .
12925611	0	BMP-2	15,20	IL-1	62,66	BMP-2	IL-1	650	3553	Gene	Gene	expression|compound|START_ENTITY Stimulation|nmod|expression Stimulation|nmod|END_ENTITY	Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes .
20232298	0	BMP-2	16,21	ILK	37,40	BMP-2	ILK	650	3611	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Hypoxia induces BMP-2 expression via ILK , Akt , mTOR , and HIF-1 pathways in osteoblasts .
16622178	0	BMP-2	25,30	Id-1	16,20	BMP-2	Id-1	12156(Tax:10090)	15901(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes .
26332449	0	BMP-2	0,5	Lgr4	15,19	BMP-2	Lgr4	650	55366	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	BMP-2 Enhances Lgr4 Gene Expression in Osteoblastic Cells .
12759356	0	BMP-2	33,38	NF-kappaB	0,9	BMP-2	NF-kappaB	12156(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro .
23977305	0	BMP-2	92,97	Noggin	57,63	BMP-2	Noggin	650	9241	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Enhanced osteogenesis of adipose derived stem cells with Noggin suppression and delivery of BMP-2 .
22496405	0	BMP-2	0,5	Nox4	78,82	BMP-2	Nox4	650	50507	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation .
18056716	0	BMP-2	0,5	Osterix	14,21	BMP-2	Osterix	12156(Tax:10090)	170574(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38 .
26217938	0	BMP-2	0,5	PLCb1	28,33	BMP-2	PLCb1	12156(Tax:10090)	18795(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	BMP-2 Induced Expression of PLCb1 That Is a Positive Regulator of Osteoblast Differentiation .
18247361	0	BMP-2	0,5	PTHrP	20,25	BMP-2	PTHrP	12156(Tax:10090)	19227(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells .
19672814	0	BMP-2	32,37	Parathyroid_hormone	0,19	BMP-2	Parathyroid hormone	12156(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Parathyroid_hormone upregulates BMP-2 mRNA expression through mevalonate_kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells .
26935542	0	BMP-2	62,67	RUNX2	68,73	BMP-2	RUNX2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Linarin promotes osteogenic differentiation by activating the BMP-2 / RUNX2 pathway via protein kinase A signaling .
12753866	0	BMP-2	47,52	Runx2	113,118	BMP-2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY fibroblasts|acl|expressing Transplantation|nmod|fibroblasts promotes|nsubj|Transplantation promotes|advcl|expressing expressing|dobj|END_ENTITY	Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2 .
26455827	0	BMP-2	88,93	Runx2	107,112	BMP-2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	Proliferation|nmod|START_ENTITY MC3T3-E1|dep|Proliferation MC3T3-E1|parataxis|Smad/p38/JNK Smad/p38/JNK|dep|Pathway Pathway|compound|END_ENTITY	Sambucus Williamsii Hance Promotes MC3T3-E1 Cells Proliferation and Differentiation via BMP-2 / Smad/p38/JNK / Runx2 Signaling Pathway .
25418420	0	BMP-2	97,102	Secreted_Phosphoprotein_24_kD	45,74	BMP-2	Secreted Phosphoprotein 24 kD	650	6694	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	A Carboxy Terminal BMP/TGF-b Binding Site in Secreted_Phosphoprotein_24_kD Independently Affects BMP-2 Activity .
22842877	0	BMP-2	40,45	Smad4	46,51	BMP-2	Smad4	650	4089	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Icariin promotes bone formation via the BMP-2 / Smad4 signal transduction pathway in the hFOB_1 .19 human osteoblastic cell line .
26334966	0	BMP-2	99,104	Spp24	33,38	BMP-2	Spp24	650	6694	Gene	Gene	caused|nmod|START_ENTITY cells|acl|caused growth|nmod|cells inhibits|dobj|growth inhibits|nsubj|kD kD|appos|END_ENTITY	Secreted phosphoprotein 24 kD -LRB- Spp24 -RRB- inhibits growth of human pancreatic_cancer cells caused by BMP-2 .
26447026	0	BMP-2	87,92	TGF-b1	93,99	BMP-2	TGF-b1	650	7040	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of low-level diode laser therapy on early differentiation of osteoblast via BMP-2 / TGF-b1 and its receptors .
12539376	0	BMP-2	24,29	TGF_beta	12,20	BMP-2	TGF beta	650	7040	Gene	Gene	cells|compound|START_ENTITY Effects|nmod|cells Effects|nmod|END_ENTITY	-LSB- Effects of TGF_beta on BMP-2 gene transfection cells in vitro -RSB- .
21325271	3	BMP-2	552,557	TLR4	530,534	BMP-2	TLR4	650	7099	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	The aim of this study was to determine the effect of oxidized low density lipoprotein -LRB- oxLDL -RRB- on BMP-2 protein expression in human coronary artery endothelial cells -LRB- CAECs -RRB- , the roles of Toll-like receptor -LRB- TLR -RRB- 2 and TLR4 in oxLDL-induced BMP-2 expression , and the signaling pathways involved .
19795382	0	BMP-2	0,5	beta-catenin	16,28	BMP-2	beta-catenin	12156(Tax:10090)	12387(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts .
15385883	0	BMP-2	40,45	bone_morphogenetic_protein-2	10,38	BMP-2	bone morphogenetic protein-2	29373(Tax:10116)	29373(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- on matrix production , other BMPs , and BMP receptors in rat intervertebral disc cells .
8018727	0	BMP-2	67,72	bone_morphogenetic_protein-2	32,60	BMP-2	bone morphogenetic protein-2	12156(Tax:10090)	12156(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and sequence of mouse bone_morphogenetic_protein-2 gene -LRB- BMP-2 -RRB- : comparison of the structures and promoter regions of BMP-2 and BMP-4 genes .
11600747	0	BMP-2	43,48	bone_morphogenic_protein-2	15,41	BMP-2	bone morphogenic protein-2	650	650	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of bone_morphogenic_protein-2 -LRB- BMP-2 -RRB- in the pathological ossification process of_the_spinal_ligament .
15777655	0	BMP-2	83,88	fibroblast_growth_factor-2	9,35	BMP-2	fibroblast growth factor-2	12156(Tax:10090)	14173(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Low dose fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- enhances bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- - induced ectopic bone formation in mice .
14597420	0	BMP-2	37,42	p38	14,17	BMP-2	p38	650	1432	Gene	Gene	effects|compound|START_ENTITY mediates|dobj|effects mediates|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts .
18056716	0	BMP-2	0,5	p38	90,93	BMP-2	p38	12156(Tax:10090)	26416(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38 .
23518236	0	BMP-2	29,34	p38	52,55	BMP-2	p38	650	1432	Gene	Gene	expression|compound|START_ENTITY expression|nmod|kinase kinase|amod|END_ENTITY	Nanohydroxyapatite increases BMP-2 expression via a p38 MAP kinase dependent pathway in periodontal ligament cells .
26708156	0	BMP-2	24,29	p38	92,95	BMP-2	p38	650	1432	Gene	Gene	driven|amod|START_ENTITY stimulation|amod|driven stimulation|nmod|chondrocytes chondrocytes|nmod|MAPK MAPK|amod|END_ENTITY	Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK .
26123746	0	BMP-2	123,128	receptor_activator_of_nuclear_factor_kB_ligand	54,100	Smad1	receptor activator of nuclear factor kB ligand	4086	8600	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	RNA interference-mediated knockdown of Smad1 inhibits receptor_activator_of_nuclear_factor_kB_ligand expression induced by BMP-2 in primary osteoblasts .
18253966	0	BMP-2	51,56	spp24	19,24	BMP-2	spp24	615037(Tax:9913)	281500(Tax:9913)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|spp24 spp24|amod|END_ENTITY	Full-length bovine spp24 -LSB- spp24 -LRB- 24-203 -RRB- -RSB- inhibits BMP-2 induced bone formation .
18253966	0	BMP-2	51,56	spp24	26,31	BMP-2	spp24	615037(Tax:9913)	281500(Tax:9913)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Full-length bovine spp24 -LSB- spp24 -LRB- 24-203 -RRB- -RSB- inhibits BMP-2 induced bone formation .
20162696	0	BMP-2	95,100	spp24	52,57	BMP-2	spp24	650	6694	Gene	Gene	activity|compound|START_ENTITY inhibition|nmod|activity essential|nmod|inhibition essential|nsubj|terminus terminus|nmod|secreted_phosphoprotein-24_kDa secreted_phosphoprotein-24_kDa|appos|END_ENTITY	Carboxy terminus of secreted_phosphoprotein-24_kDa -LRB- spp24 -RRB- is essential for full inhibition of BMP-2 activity .
24147033	0	BMP-2	0,5	versican	14,22	BMP-2	versican	378779(Tax:9031)	395565(Tax:9031)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration .
9069167	0	BMP-3	46,51	Bone_morphogenetic_protein_2	0,28	BMP-3	Bone morphogenetic protein 2	25667(Tax:10116)	29373(Tax:10116)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Bone_morphogenetic_protein_2 -LRB- BMP-2 -RRB- enhances BMP-3 , BMP-4 , and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts .
19021035	0	BMP-4	10,15	BMP-2	0,5	BMP-4	BMP-2	652	650	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts : Smad signaling , not alkaline_phosphatase activity , predicts rescue of mineralization .
21898398	0	BMP-4	15,20	CCN3	0,4	BMP-4	CCN3	652	4856	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	CCN3 increases BMP-4 expression and bone mineralization in osteoblasts .
17960174	0	BMP-4	0,5	Kit	18,21	BMP-4	Kit	12159(Tax:10090)	16590(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	BMP-4 upregulates Kit expression in mouse melanoblasts prior to the Kit-dependent cycle of melanogenesis .
11476570	0	BMP-4	32,37	MAP_kinase	14,24	BMP-4	MAP kinase	399322(Tax:8355)	398985(Tax:8355)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MAP_kinase by the BMP-4 / TAK1 pathway in Xenopus ectoderm .
8645604	0	BMP-4	44,49	SHH	145,148	BMP-4	SHH	396165(Tax:9031)	395615(Tax:9031)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of bone_morphogenetic_protein-4 -LRB- BMP-4 -RRB- , bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- , fibroblast_growth_factor-8 -LRB- FGF-8 -RRB- and sonic_hedgehog -LRB- SHH -RRB- during branchial arch development in the chick .
9449668	0	BMP-4	33,38	Smad8	8,13	BMP-4	Smad8	397874(Tax:8355)	379659(Tax:8355)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning .
9701626	0	BMP-4	40,45	bone_morphogenetic_protein_4	10,38	BMP-4	bone morphogenetic protein 4	652	652	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human bone_morphogenetic_protein_4 -LRB- BMP-4 -RRB- gene : molecular structure and transcriptional regulation .
11044605	0	BMP-4	23,28	c-Jun	0,5	BMP-4	c-Jun	397874(Tax:8355)	399400(Tax:8355)	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	c-Jun -LRB- AP-1 -RRB- activates BMP-4 transcription in Xenopus embryos .
9178255	0	BMP-4	73,78	follistatin	41,52	BMP-4	follistatin	12159(Tax:10090)	14313(Tax:10090)	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4 .
9707432	0	BMP-4	0,5	furin	38,43	BMP-4	furin	399322(Tax:8355)	398345(Tax:8355)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development .
21319131	0	BMP-5	42,47	bone_morphogenetic_protein-5	12,40	BMP-5	bone morphogenetic protein-5	653	653	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of bone_morphogenetic_protein-5 -LRB- BMP-5 -RRB- in human nephrosclerosis .
17997862	0	BMP-6	0,5	E-cadherin	15,25	BMP-6	E-cadherin	654	999	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast_cancer cells .
21136273	0	BMP-6	0,5	MMP-9	15,20	BMP-6	MMP-9	654	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast_cancer cells .
20401668	0	BMP-6	15,20	PTHrP	0,5	BMP-6	PTHrP	654	5744	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast_cancer cells .
7547504	0	BMP-6	6,11	Vgr-1	0,5	BMP-6	Vgr-1	654	654	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Vgr-1 / BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells .
11732805	0	BMP-6	44,49	bone_morphogenetic_protein-6	14,42	BMP-6	bone morphogenetic protein-6	654	654	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of bone_morphogenetic_protein-6 -LRB- BMP-6 -RRB- in myoepithelial cells in canine mammary gland_tumors .
7707865	0	BMP-6	89,94	bone_morphogenetic_protein-6	59,87	BMP-6	bone morphogenetic protein-6	25644(Tax:10116)	25644(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Developmental alteration and neuron-specific expression of bone_morphogenetic_protein-6 -LRB- BMP-6 -RRB- mRNA in rodent brain .
15040833	0	BMP-6	32,37	estrogen_receptor_alpha	50,73	BMP-6	estrogen receptor alpha	654	2099	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Transcriptional regulation of a BMP-6 promoter by estrogen_receptor_alpha .
19308091	0	BMP-6	0,5	microRNA-21	15,26	BMP-6	microRNA-21	654	406991	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	BMP-6 inhibits microRNA-21 expression in breast_cancer through repressing deltaEF1 and AP-1 .
7751058	0	BMP-6	27,32	vgr	22,25	BMP-6	vgr	25644(Tax:10116)	25644(Tax:10116)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of vgr -LRB- BMP-6 , DVR-6 -RRB- , a TGF-beta related cytokine , to Schwann cells of the rat peripheral nervous system : expression patterns are not modulated by autoimmune_disease .
26824441	0	BMP-7	0,5	Apo_E	105,110	BMP-7	Apo E	12162(Tax:10090)	11816(Tax:10090)	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	BMP-7 Treatment Increases M2 Macrophage Differentiation and Reduces Inflammation and Plaque Formation in Apo_E - / - Mice .
19597895	0	BMP-7	25,30	BMP	43,46	BMP-7	BMP	655	649	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion : a pilot study .
18458495	0	BMP-7	60,65	BMP-2	10,15	BMP-7	BMP-2	655	650	Gene	Gene	homodimers|nsubj|START_ENTITY Effect|parataxis|homodimers Effect|nmod|homodimers homodimers|compound|END_ENTITY	Effect of BMP-2 and BMP-7 homodimers and a mixture of BMP-2 / BMP-7 homodimers on osteoblast adhesion and growth following culture on a collagen scaffold .
19361857	0	BMP-7	36,41	BMP-2	30,35	BMP-7	BMP-2	85272(Tax:10116)	29373(Tax:10116)	Gene	Gene	system|compound|START_ENTITY Incorporation|dep|system Incorporation|nmod|END_ENTITY	Incorporation of a sequential BMP-2 / BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering .
19585564	0	BMP-7	17,22	BMP-2	11,16	BMP-7	BMP-2	85272(Tax:10116)	29373(Tax:10116)	Gene	Gene	delivery|compound|START_ENTITY nanocapsules|nsubj|delivery END_ENTITY|parataxis|nanocapsules	Sequential BMP-2 / BMP-7 delivery from polyester nanocapsules .
9102298	0	BMP-7	24,29	BMP-2	8,13	BMP-7	BMP-2	395494(Tax:9031)	378779(Tax:9031)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of BMP-2 and OP-1 -LRB- BMP-7 -RRB- in programmed cell death and skeletogenesis during chick limb development .
15452148	0	BMP-7	39,44	CD44	0,4	BMP-7	CD44	655	960	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	CD44 modulates Smad1 activation in the BMP-7 signaling pathway .
18632843	0	BMP-7	14,19	CTGF	0,4	BMP-7	CTGF	12162(Tax:10090)	14219(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	CTGF inhibits BMP-7 signaling in diabetic_nephropathy .
22099397	0	BMP-7	0,5	CTGF	119,123	BMP-7	CTGF	655	1490	Gene	Gene	START_ENTITY|appos|signalling signalling|nmod|myoblasts myoblasts|dep|components components|acl|involved involved|nmod|blockage blockage|nmod|expression expression|amod|END_ENTITY	BMP-7 / TGF-b1 signalling in myoblasts : components involved in signalling and BMP-7-dependent blockage of TGF-b-mediated CTGF expression .
22215634	0	BMP-7	33,38	MMP-7	12,17	BMP-7	MMP-7	655	4316	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Matrilysin -LRB- MMP-7 -RRB- inhibition of BMP-7 induced renal tubular branching morphogenesis suggests a role in the pathogenesis of human renal_dysplasia .
23515721	0	BMP-7	61,66	MyoR	46,50	BMP-7	MyoR	12162(Tax:10090)	17681(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Basic helix-loop-helix transcriptional factor MyoR regulates BMP-7 in acute_kidney_injury .
11527145	0	BMP-7	6,11	OP-1	12,16	BMP-7	OP-1	655	655	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Human BMP-7 / OP-1 induces the growth and differentiation of adipocytes and osteoblasts in bone marrow stromal cell cultures .
10332154	0	BMP-7	92,97	bFGF	55,59	BMP-7	bFGF	85272(Tax:10116)	54250(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	-LSB- Biological effects of basic fibroblast growth factor -LRB- bFGF -RRB- and osteogenic protein-1 -LRB- OP-1 / BMP-7 -RRB- on bone marrow cells and development of cell-hybrid artificial bone -RSB- .
11846481	0	BMP-7	52,57	bone_morphogenetic_protein-7	22,50	BMP-7	bone morphogenetic protein-7	395494(Tax:9031)	395494(Tax:9031)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Follistatin regulates bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- activity to stimulate embryonic muscle growth .
14991870	0	BMP-7	44,49	bone_morphogenetic_protein-7	14,42	BMP-7	bone morphogenetic protein-7	655	655	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- in human prostate .
15293217	0	BMP-7	41,46	bone_morphogenetic_protein-7	11,39	BMP-7	bone morphogenetic protein-7	12162(Tax:10090)	12162(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- on primordial follicular growth in the mouse ovary .
22476375	0	BMP-7	66,71	bone_morphogenetic_protein_7	36,64	BMP-7	bone morphogenetic protein 7	655	655	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Results of nonunion treatment with bone_morphogenetic_protein_7 -LRB- BMP-7 -RRB- -RSB- .
23471555	0	BMP-7	55,60	bone_morphogenic_protein-7	28,54	BMP-7	bone morphogenic protein-7	85272(Tax:10116)	85272(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The anti-fibrotic effect of bone_morphogenic_protein-7 -LRB- BMP-7 -RRB- on liver_fibrosis .
10418861	0	BMP-7	61,66	osteogenic_protein-1	39,59	BMP-7	osteogenic protein-1	655	655	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Preclinical and clinical evaluation of osteogenic_protein-1 -LRB- BMP-7 -RRB- in bony sites .
17311849	0	BMP-9	0,5	ALK1	18,22	BMP-9	ALK1	2658	94	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis .
25297851	0	BMP-9	0,5	ALK1	110,114	BMP-9	ALK1	2658	6590	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway .
22299030	0	BMP-9	0,5	Smad1	85,90	BMP-9	Smad1	2658	4086	Gene	Gene	involves|nsubj|START_ENTITY involves|dobj|END_ENTITY	BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production .
27085971	0	BMP-9	0,5	fibroblast_growth_factor_21	15,42	BMP-9	fibroblast growth factor 21	2658	26291	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	BMP-9 enhances fibroblast_growth_factor_21 expression and suppresses obesity .
19639633	0	BMP-binding_peptide	20,39	BMP-2	72,77	BMP-binding peptide	BMP-2	25907	650	Gene	Gene	effects|nmod|START_ENTITY combined|nsubj|effects combined|nmod|END_ENTITY	Enhanced effects of BMP-binding_peptide combined with recombinant human BMP-2 on the healing of a rodent_segmental_femoral_defect .
8404039	0	BMP1	50,54	bone_morphogenetic_protein_1	15,43	BMP1	bone morphogenetic protein 1	649	649	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the bone_morphogenetic_protein_1 gene -LRB- BMP1 -RRB- to 8p21 : removal of BMP1 from candidacy for the bone_disorder in Langer-Giedion_syndrome .
23584484	0	BMP1	93,97	kip1	106,110	BMP1	kip1	649	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	miR-194 suppresses metastasis of non-small cell lung_cancer through regulating expression of BMP1 and p27 -LRB- kip1 -RRB- .
24551273	0	BMP10	35,40	BMP5	29,33	BMP10	BMP5	27302	653	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Expression analysis of BMP2 , BMP5 , BMP10 in human colon tissues from Hirschsprung_disease patients .
22996691	0	BMP10	20,25	Myocardin	0,9	BMP10	Myocardin	27302	93649	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Myocardin regulates BMP10 expression and is required for heart development .
23645739	0	BMP10	45,50	bone_morphogenetic_protein-10	14,43	BMP10	bone morphogenetic protein-10	27302	27302	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of bone_morphogenetic_protein-10 -LRB- BMP10 -RRB- in human urothelial_cancer_of_the_bladder and its effects on the aggressiveness of bladder_cancer cells in vitro .
18282670	0	BMP15	55,60	Bone_Morphogenetic_Protein_15	24,53	BMP15	Bone Morphogenetic Protein 15	100141303(Tax:9940)	100141303(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A 17 bp deletion in the Bone_Morphogenetic_Protein_15 -LRB- BMP15 -RRB- gene is associated to increased prolificacy in the Rasa Aragonesa sheep breed .
24140593	0	BMP15	0,5	StAR	60,64	BMP15	StAR	9210	6770	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells .
15136966	0	BMP15	112,117	bone_morphogenetic_protein-15	81,110	BMP15	bone morphogenetic protein-15	9210	9210	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Hypergonadotropic_ovarian_failure associated with an inherited mutation of human bone_morphogenetic_protein-15 -LRB- BMP15 -RRB- gene .
19433911	0	BMP15	92,97	bone_morphogenetic_protein_15	56,85	BMP15	bone morphogenetic protein 15	353351(Tax:9913)	353351(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detecting a deletion in the coding region of the bovine bone_morphogenetic_protein_15 gene -LRB- BMP15 -RRB- .
23877969	0	BMP15	115,120	bone_morphogenic_protein-15	86,113	BMP15	bone morphogenic protein-15	9210	9210	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Anti-M llerian hormone -LRB- AMH -RRB- , inhibin-a , growth_differentiation_factor_9 -LRB- GDF9 -RRB- , and bone_morphogenic_protein-15 -LRB- BMP15 -RRB- mRNA and protein are influenced by photoperiod-induced ovarian regression and recrudescence in Siberian hamster ovaries .
20505824	0	BMP2	12,16	Agrin	0,5	BMP2	Agrin	29373(Tax:10116)	25592(Tax:10116)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Agrin binds BMP2 , BMP4 and TGFbeta1 .
23244588	0	BMP2	0,4	BMP4	20,24	BMP2	BMP4	650	652	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	BMP2 is superior to BMP4 for promoting human muscle-derived stem cell-mediated bone regeneration in a critical-sized calvarial_defect model .
22644325	0	BMP2	0,4	Gremlin1	48,56	BMP2	Gremlin1	12156(Tax:10090)	23892(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	BMP2 differentially regulates the expression of Gremlin1 and Gremlin2 , the negative regulators of BMP function , during osteoblast differentiation .
10486560	0	BMP2	62,66	LIF	38,41	BMP2	LIF	12156(Tax:10090)	16878(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Astrocyte differentiation mediated by LIF in cooperation with BMP2 .
18703512	0	BMP2	0,4	Msx2	31,35	BMP2	Msx2	12156(Tax:10090)	17702(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation .
21471203	0	BMP2	63,67	Msx2	87,91	BMP2	Msx2	650	4488	Gene	Gene	responsiveness|appos|START_ENTITY enhances|dobj|responsiveness enhances|nmod|gene gene|amod|END_ENTITY	Notch signaling pathway enhances bone_morphogenetic_protein_2 -LRB- BMP2 -RRB- responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells .
21029048	0	BMP2	50,54	Nox4	37,41	BMP2	Nox4	12156(Tax:10090)	50490(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation .
18703512	0	BMP2	0,4	Osterix	15,22	BMP2	Osterix	12156(Tax:10090)	170574(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation .
16927309	0	BMP2	70,74	Runx2	95,100	BMP2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|domain domain|amod|functional functional|advmod|END_ENTITY	Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation .
17060321	0	BMP2	0,4	Runx2	65,70	BMP2	Runx2	650	860	Gene	Gene	commitment|nummod|START_ENTITY involves|nsubj|commitment involves|dobj|activation activation|nmod|END_ENTITY	BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network .
22247071	0	BMP2	87,91	Runx2	115,120	BMP2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	c-Jun_N-terminal_kinase_1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104 .
14635200	0	BMP2	59,63	Smad1	99,104	BMP2	Smad1	378779(Tax:9031)	395680(Tax:9031)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Runx2/Cbfa1 stimulation by retinoic_acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes .
24808138	0	BMP2	38,42	Smad1	0,5	BMP2	Smad1	378779(Tax:9031)	395680(Tax:9031)	Gene	Gene	signals|compound|START_ENTITY integrates|dobj|signals integrates|nsubj|factor factor|amod|END_ENTITY	Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells .
25301360	0	BMP2	0,4	TNF-a	115,120	BMP2	TNF-a	650	7124	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	BMP2 Increases Adipogenic Differentiation in the Presence of Dexamethasone , which is Inhibited by the Treatment of TNF-a in Human Adipose Tissue-Derived Stromal Cells .
11087629	0	BMP2	95,99	Tbx2	113,117	BMP2	Tbx2	378779(Tax:9031)	373990(Tax:9031)	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	Expression of chick Tbx-2 , Tbx-3 , and Tbx-5 genes during early heart development : evidence for BMP2 induction of Tbx2 .
23142810	0	BMP2	24,28	WNT4	0,4	BMP2	WNT4	650	54361	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	WNT4 acts downstream of BMP2 and functions via b-catenin signaling pathway to regulate human endometrial stromal cell differentiation .
15629804	0	BMP2	119,123	bone_morphogenetic_protein2	14,41	BMP2	bone morphogenetic protein2	615037(Tax:9913)	615037(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of bone_morphogenetic_protein2 -LRB- BMP2 -RRB- , BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development .
11882013	0	BMP2	40,44	bone_morphogenetic_protein_2	10,38	BMP2	bone morphogenetic protein 2	443173(Tax:9940)	443173(Tax:9940)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of bone_morphogenetic_protein_2 -LRB- BMP2 -RRB- on oestradiol and inhibin_A production by sheep granulosa cells , and localization of BMP receptors in the ovary by immunohistochemistry .
16432645	0	BMP2	51,55	bone_morphogenetic_protein_2	21,49	BMP2	bone morphogenetic protein 2	650	650	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the bone_morphogenetic_protein_2 -LRB- BMP2 -RRB- gene do not affect bone_mineral_density in white men or women .
22074949	0	BMP3	0,4	Acvr2b	93,99	BMP3	Acvr2b	110075(Tax:10090)	11481(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b .
25077038	0	BMP3	41,45	Bone_Morphogenetic_Protein_3	11,39	BMP3	Bone Morphogenetic Protein 3	651	651	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Methylated Bone_Morphogenetic_Protein_3 -LRB- BMP3 -RRB- Gene : Evaluation of Tumor_Suppressor Function and Biomarker Potential in Biliary_Cancer .
20532035	0	BMP3	51,55	Osteogenin	39,49	BMP3	Osteogenin	651	651	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence for positive selection on the Osteogenin -LRB- BMP3 -RRB- gene in human populations .
23244588	0	BMP4	20,24	BMP2	0,4	BMP4	BMP2	652	650	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	BMP2 is superior to BMP4 for promoting human muscle-derived stem cell-mediated bone regeneration in a critical-sized calvarial_defect model .
22076569	0	BMP4	18,22	CDX2	55,59	BMP4	CDX2	652	1045	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Activation of the BMP4 pathway and early expression of CDX2 characterize non-specialized columnar metaplasia in a human model of Barrett 's _ esophagus .
22504665	0	BMP4	49,53	GATA6	69,74	BMP4	GATA6	652	2627	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	microRNA-145 in Barrett 's _ oesophagus : regulating BMP4 signalling via GATA6 .
21655089	0	BMP4	69,73	GREM1	62,67	BMP4	GREM1	652	26585	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Multiple common susceptibility variants near BMP pathway loci GREM1 , BMP4 , and BMP2 explain part of the missing heritability of colorectal_cancer .
15987774	0	BMP4	54,58	Gata4	0,5	BMP4	Gata4	12159(Tax:10090)	14463(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|nsubj|expression expression|amod|END_ENTITY	Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element .
22019704	0	BMP4	0,4	HMGA2	29,34	BMP4	HMGA2	652	8091	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	BMP4 increases expression of HMGA2 in mesenchymal stem cells .
17600318	0	BMP4	0,4	HO-1	13,17	BMP4	HO-1	652	3162	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	BMP4 induces HO-1 via a Smad-independent , p38MAPK-dependent pathway in pulmonary artery myocytes .
18372118	0	BMP4	10,14	ID3	36,39	BMP4	ID3	652	3399	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Autocrine BMP4 signalling regulates ID3 proto-oncogene expression in human ovarian_cancer cells .
16547003	0	BMP4	0,4	Id2	60,63	BMP4	Id2	25296(Tax:10116)	25587(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	BMP4 regulates pancreatic progenitor cell expansion through Id2 .
22383492	0	BMP4	25,29	KRAS	10,14	BMP4	KRAS	652	3845	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oncogenic KRAS regulates BMP4 expression in colon_cancer cell lines .
23255092	0	BMP4	16,20	Lin28	0,5	BMP4	Lin28	652	79727	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Lin28 regulates BMP4 and functions with Oct4 to affect ovarian_tumor microenvironment .
26782975	0	BMP4	60,64	MicroRNA-378	0,12	BMP4	MicroRNA-378	12159(Tax:10090)	723889(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-378 promotes myogenic differentiation by targeting BMP4 .
23255092	0	BMP4	16,20	Oct4	40,44	BMP4	Oct4	652	5460	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Lin28 regulates BMP4 and functions with Oct4 to affect ovarian_tumor microenvironment .
25511584	0	BMP4	107,111	arylsulfatase_B	88,103	BMP4	arylsulfatase B	652	411	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
25085606	0	BMP4	41,45	bone_morphogenetic_protein_4	11,39	BMP4	bone morphogenetic protein 4	443502(Tax:9940)	443502(Tax:9940)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of bone_morphogenetic_protein_4 -LRB- BMP4 -RRB- supplementation during culture of the sheep ovarian cortex .
26970275	0	BMP4	44,48	bone_morphogenetic_protein_4	14,42	BMP4	bone morphogenetic protein 4	12159(Tax:10090)	12159(Tax:10090)	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	The impact of bone_morphogenetic_protein_4 -LRB- BMP4 -RRB- on breast_cancer metastasis in a mouse xenograft model .
25511584	0	BMP4	107,111	chondroitin-4-sulfotransferase	14,44	BMP4	chondroitin-4-sulfotransferase	652	50515	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
17522159	0	BMP4	13,17	gremlin_1	30,39	BMP4	gremlin 1	12159(Tax:10090)	23892(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Reduction of BMP4 activity by gremlin_1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis .
23395997	0	BMP4	34,38	lysyl_oxidase	60,73	BMP4	lysyl oxidase	12159(Tax:10090)	16948(Tax:10090)	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Induction of EMT-like response by BMP4 via up-regulation of lysyl_oxidase is required for adipocyte lineage commitment .
9272945	0	BMP4	67,71	msx1	8,12	BMP4	msx1	399322(Tax:8355)	100125666(Tax:8355)	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4 .
24551273	0	BMP5	29,33	BMP10	35,40	BMP5	BMP10	653	27302	Gene	Gene	analysis|nmod|START_ENTITY END_ENTITY|nsubj|analysis	Expression analysis of BMP2 , BMP5 , BMP10 in human colon tissues from Hirschsprung_disease patients .
27046124	0	BMP6	70,74	GPR91	60,65	BMP6	GPR91	12161(Tax:10090)	84112(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile_Hemochromatosis .
21622652	0	BMP6	25,29	TMPRSS6	14,21	BMP6	TMPRSS6	654	164656	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of TMPRSS6 by BMP6 and iron in human cells and mice .
9748228	0	BMP7	55,59	ALK2	77,81	BMP7	ALK2	12162(Tax:10090)	11477(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Specific activation of Smad1 signaling pathways by the BMP7 type I receptor , ALK2 .
20673479	0	BMP7	1,5	BMPR1B	28,34	BMP7	BMPR1B	655	658	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	-LSB- BMP7 signaling via BMPR1A , BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell -RSB- .
17522432	0	BMP7	30,34	Bone_morphogenetic_protein_7	0,28	BMP7	Bone morphogenetic protein 7	655	655	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Bone_morphogenetic_protein_7 -LRB- BMP7 -RRB- expression is a potential novel prognostic marker for recurrence in patients with primary melanoma .
22241179	0	BMP7	44,48	LIM_domain_protein-3	0,20	BMP7	LIM domain protein-3	655	9260	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	LIM_domain_protein-3 -LRB- LMP3 -RRB- cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells .
17452977	0	BMP7	53,57	LMO4	20,24	BMP7	LMO4	655	8543	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism , and controls cell proliferation and apoptosis of mammary epithelial cells .
26610487	0	BMP7	80,84	MiR542-3p	0,9	BMP7	MiR542-3p	85272(Tax:10116)	104797379	Gene	Gene	Regulates|nmod|START_ENTITY Regulates|nsubj|END_ENTITY	MiR542-3p Regulates the Epithelial-Mesenchymal Transition by Directly Targeting BMP7 in NRK52e .
19505455	0	BMP7	0,4	Pax2	22,26	BMP7	Pax2	12162(Tax:10090)	18504(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression .
24035155	0	BMP7	56,60	bone_morphogenetic_protein_7	21,49	BMP7	bone morphogenetic protein 7	655	655	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of the bone_morphogenetic_protein_7 gene -LRB- BMP7 -RRB- and association analysis with sow productive traits .
23300529	0	BMP9	25,29	Endoglin	0,8	BMP9	Endoglin	2658	2022	Gene	Gene	requirement|nmod|START_ENTITY requirement|compound|END_ENTITY	Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies .
22622516	0	BMP9	0,4	EphrinB2	13,21	BMP9	EphrinB2	12165(Tax:10090)	13642(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID 1/ID3-dependent pathway : implications for hereditary_hemorrhagic_telangiectasia_type_II .
22467218	0	BMP9	31,35	Growth_hormone	0,14	BMP9	Growth hormone	12165(Tax:10090)	14599(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Growth_hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells .
25237187	0	BMP9	44,48	bone_morphogenetic_protein_9	14,42	BMP9	bone morphogenetic protein 9	2658	2658	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of bone_morphogenetic_protein_9 -LRB- BMP9 -RRB- by redox-dependent proteolysis .
26460584	0	BMP9	23,27	miR-21	0,6	BMP9	miR-21	12165(Tax:10090)	387140(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells .
19211807	0	BMPR1A	41,47	Bone_morphogenetic_protein_2	0,28	BMPR1A	Bone morphogenetic protein 2	12166(Tax:10090)	12156(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Bone_morphogenetic_protein_2 signals via BMPR1A to regulate murine follicle-stimulating_hormone_beta_subunit transcription .
17325551	0	BMPR1A	98,104	Cyclooxygenase-2	0,16	BMPR1A	Cyclooxygenase-2	657	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 expression in polyps from a patient with juvenile_polyposis_syndrome with mutant BMPR1A .
22374147	0	BMPR1B	26,32	ALK6	34,38	BMPR1B	ALK6	658	658	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Missense mutations of the BMPR1B -LRB- ALK6 -RRB- gene in childhood idiopathic_pulmonary_arterial_hypertension .
20673479	0	BMPR1B	28,34	BMP7	1,5	BMPR1B	BMP7	658	655	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	-LSB- BMP7 signaling via BMPR1A , BMPR1B inhibits the proliferation of lung large carcinoma NCI-H460 cell -RSB- .
11312159	0	BMPR1B	105,111	bone_morphogenetic_receptor_type_1_B	67,103	BMPR1B	bone morphogenetic receptor type 1 B	443454(Tax:9940)	443454(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Booroola -LRB- FecB -RRB- phenotype is associated with a mutation in the bone_morphogenetic_receptor_type_1_B -LRB- BMPR1B -RRB- gene .
12134634	0	BMPR2	51,56	TGF-beta	31,39	BMPR2	TGF-beta	659	7040	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	-LSB- Mutations of genes coding for TGF-beta receptors -LRB- BMPR2 and ALK-1 -RRB- in primary pulmonary_arterial_hypertension -RSB- .
27059117	0	BMPR2	79,84	miR-375	0,7	BMPR2	miR-375	659	494324	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-375 negatively regulates porcine preadipocyte differentiation by targeting BMPR2 .
15538389	0	BMPRII	52,58	LIMK1	14,19	BMPRII	LIMK1	659	3984	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of LIMK1 by binding to the BMP receptor , BMPRII , regulates BMP-dependent dendritogenesis .
19578724	0	BMPRII	0,6	miR-21	29,35	BMPRII	miR-21	659	406991	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	BMPRII is a direct target of miR-21 .
9929985	0	BMP_4	76,81	bone_morphogenetic_protein-4	46,74	BMP 4	bone morphogenetic protein-4	652	652	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A single-nucleotide polymorphism in the human bone_morphogenetic_protein-4 -LRB- BMP_4 -RRB- gene .
24601881	0	BMP_type_1A_receptor	79,99	Bone_morphogenetic_protein_2	0,28	BMP type 1A receptor	Bone morphogenetic protein 2	12166(Tax:10090)	12156(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Bone_morphogenetic_protein_2 stimulates noncanonical SMAD2/3 signaling via the BMP_type_1A_receptor in gonadotrope-like cells : implications for FSH synthesis .
24601881	0	BMP_type_1A_receptor	79,99	SMAD2/3	53,60	BMP type 1A receptor	SMAD2/3	12166(Tax:10090)	17126;17127	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Bone_morphogenetic_protein_2 stimulates noncanonical SMAD2/3 signaling via the BMP_type_1A_receptor in gonadotrope-like cells : implications for FSH synthesis .
18343828	0	BMRF1	80,85	BGLF4	115,120	BMRF1	BGLF4	17494230	3783704(Tax:10376)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Effect of phosphorylation on the transactivation activity of Epstein-Barr_virus BMRF1 , a major target of the viral BGLF4 kinase .
15613302	0	BMRF1	31,36	gastrin	47,54	BMRF1	gastrin	17494230	2520	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	The Epstein-Barr_virus protein BMRF1 activates gastrin transcription .
20399856	0	BMWCP10	67,74	cuticle_protein	45,60	BMWCP10	cuticle protein	692438(Tax:7091)	692409(Tax:7091)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Ecdysone directly and indirectly regulates a cuticle_protein gene , BMWCP10 , in the wing disc of Bombyx_mori .
19580866	0	BMWCP5	101,107	cuticle_protein	79,94	BMWCP5	cuticle protein	100379326(Tax:7091)	692409(Tax:7091)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	betaFTZ-F1 and Broad-Complex positively regulate the transcription of the wing cuticle_protein gene , BMWCP5 , in wing discs of Bombyx_mori .
24709422	0	BMX	0,3	PI3K	23,27	BMX	PI3K	660	5293	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	BMX acts downstream of PI3K to promote colorectal_cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737 .
24351232	0	BNDF	51,55	brain-derived_neurotrophic_factor	16,49	BNDF	brain-derived neurotrophic factor	627	627	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of brain-derived_neurotrophic_factor -LRB- BNDF -RRB- in multiple_sclerosis patients with Trichuris_suis ova therapy .
12901880	0	BNIP-2	30,36	BNIPL-2	0,7	BNIP-2	BNIPL-2	663	149428	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	BNIPL-2 , a novel homologue of BNIP-2 , interacts with Bcl-2 and Cdc42GAP in apoptosis .
18445682	0	BNIP2	0,5	RhoGEF	66,72	BNIP2	RhoGEF	663	9826	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain .
21242194	0	BNIP2	16,21	miR-20a	0,7	BNIP2	miR-20a	663	406982	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal_adenocarcinoma SW480 and SW620 cell lines .
18371312	0	BNIP3	72,77	Acetyl-Coenzyme_A_acyltransferase_2	0,35	BNIP3	Acetyl-Coenzyme A acyltransferase 2	664	10449	Gene	Gene	effects|nmod|START_ENTITY attenuates|dobj|effects attenuates|nsubj|END_ENTITY	Acetyl-Coenzyme_A_acyltransferase_2 attenuates the apoptotic effects of BNIP3 in two human cell lines .
16217754	0	BNIP3	40,45	Bcl-2	19,24	BNIP3	Bcl-2	664	596	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	The pro-cell death Bcl-2 family member , BNIP3 , is localized to the nucleus of human glial cells : Implications for glioblastoma_multiforme_tumor cell survival under hypoxia .
19745227	0	BNIP3	1,6	Bcl-2	44,49	BNIP3	Bcl-2	664	596	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	-LSB- BNIP3 as an atypical representative of the Bcl-2 protein family .
19745228	0	BNIP3	1,6	Bcl-2	44,49	BNIP3	Bcl-2	664	596	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	-LSB- BNIP3 as an atypical representative of the Bcl-2 protein family .
21868531	0	BNIP3	33,38	H-ras	0,5	BNIP3	H-ras	664	3265	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	H-ras up-regulates expression of BNIP3 .
22455137	0	BNIP3	15,20	HIF-1alpha	45,55	BNIP3	HIF-1alpha	664	3091	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of BNIP3 and its correlations to HIF-1alpha and VEGF in clear_cell_renal_cell_carcinoma -RSB- .
20852920	0	BNIP3	0,5	IL6	14,17	BNIP3	IL6	664	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells .
20332243	0	BNIP3	20,25	MicroRNA145	0,11	BNIP3	MicroRNA145	664	406937	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MicroRNA145 targets BNIP3 and suppresses prostate_cancer progression .
26012884	0	BNIP3	30,35	Sp3	39,42	BNIP3	Sp3	664	6670	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of BNIP3 by Sp3 in prostate_cancer .
18359286	0	BNIP3	72,77	Thymidine_phosphorylase	0,23	BNIP3	Thymidine phosphorylase	664	1890	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Thymidine_phosphorylase inhibits the expression of proapoptotic protein BNIP3 .
23688833	0	BNIP3	19,24	miR-210	0,7	BNIP3	miR-210	664	406992	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	miR-210 suppresses BNIP3 to protect against the apoptosis of neural progenitor cells .
21792176	0	BNIP3	24,29	p53	0,3	BNIP3	p53	336116(Tax:7955)	30590(Tax:7955)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death .
12901880	0	BNIPL-2	0,7	BNIP-2	30,36	BNIPL-2	BNIP-2	149428	663	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	BNIPL-2 , a novel homologue of BNIP-2 , interacts with Bcl-2 and Cdc42GAP in apoptosis .
12901880	0	BNIPL-2	0,7	Bcl-2	53,58	BNIPL-2	Bcl-2	149428	596	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BNIPL-2 , a novel homologue of BNIP-2 , interacts with Bcl-2 and Cdc42GAP in apoptosis .
16098869	0	BNP	42,45	B-type_natriuretic_peptide	14,40	BNP	B-type natriuretic peptide	4879	4879	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Evaluation of B-type_natriuretic_peptide -LRB- BNP -RRB- levels in normal and preeclamptic women .
17044575	0	BNP	52,55	B-type_natriuretic_peptide	24,50	BNP	B-type natriuretic peptide	4879	4879	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of point-of-care B-type_natriuretic_peptide -LRB- BNP -RRB- measurement on medical decision-making for older emergency department patients with dyspnea .
17567649	0	BNP	49,52	B-type_natriuretic_peptide	21,47	BNP	B-type natriuretic peptide	4879	4879	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the B-type_natriuretic_peptide -LRB- BNP -RRB- gene are associated with NT-proBNP levels but not with diabetic_nephropathy or mortality in type 1 diabetic patients .
18340156	0	BNP	57,60	B-type_natriuretic_peptide	29,55	BNP	B-type natriuretic peptide	4879	4879	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Updated algorithms for using B-type_natriuretic_peptide -LRB- BNP -RRB- levels in the diagnosis and management of congestive_heart_failure .
19650993	0	BNP	29,32	B-type_natriuretic_peptide	1,27	BNP	B-type natriuretic peptide	25105(Tax:10116)	25105(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- B-type_natriuretic_peptide -LRB- BNP -RRB- levels and the effects of carvedilol on BNP levels in juvenile rats with right_heart_failure -RSB- .
19833319	0	BNP	53,56	B-type_natriuretic_peptide	25,51	BNP	B-type natriuretic peptide	4879	4879	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	-LSB- Prognostic value of the B-type_natriuretic_peptide -LRB- BNP -RRB- in a cardiogeriatric department -RSB- .
26173591	0	BNP	38,41	B-type_natriuretic_peptide	10,36	BNP	B-type natriuretic peptide	4879	4879	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of B-type_natriuretic_peptide -LRB- BNP -RRB- on development of atrial_fibrillation in people with Type 2 diabetes .
26173591	0	BNP	38,41	B-type_natriuretic_peptide	10,36	BNP	B-type natriuretic peptide	4879	4879	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of B-type_natriuretic_peptide -LRB- BNP -RRB- on development of atrial_fibrillation in people with Type 2 diabetes .
25409418	0	BNP	52,55	Brain_Natriuretic_Peptide	25,50	BNP	Brain Natriuretic Peptide	4879	4879	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	Relationship Between the Brain_Natriuretic_Peptide -LRB- BNP -RRB- Level and Remission of Diabetic_Nephropathy with Microalbuminuria : A 3-Year Follow-Up Study .
17881654	0	BNP	0,3	SHOX	67,71	BNP	SHOX	4879	6473	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	BNP is a transcriptional target of the short stature homeobox gene SHOX .
26445241	0	BNP	84,87	brain-type_natriuretic_peptide	52,82	BNP	brain-type natriuretic peptide	4879	4879	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Maternal serum atrial natriuretic peptide -LRB- ANP -RRB- and brain-type_natriuretic_peptide -LRB- BNP -RRB- levels in gestational diabetes_mellitus .
11108284	0	BNP	44,47	brain_natriuretic_peptide	17,42	BNP	brain natriuretic peptide	100885766	100885766	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Atrial -LRB- ANP -RRB- and brain_natriuretic_peptide -LRB- BNP -RRB- expression after myocardial_infarction in sheep : ANP is synthesized by fibroblasts infiltrating the infarct .
11249937	0	BNP	48,51	brain_natriuretic_peptide	21,46	BNP	brain natriuretic peptide	4879	4879	Gene	Gene	Degradation|appos|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of human brain_natriuretic_peptide -LRB- BNP -RRB- by contact activation of blood_coagulation system .
17954830	0	BNP	35,38	brain_natriuretic_peptide	8,33	BNP	brain natriuretic peptide	4879	4879	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of brain_natriuretic_peptide -LRB- BNP -RRB- in risk stratification of adult_syncope .
20226544	0	BNP	62,65	brain_natriuretic_peptide	35,60	BNP	brain natriuretic peptide	4879	4879	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Diagnostic and prognostic value of brain_natriuretic_peptide -LRB- BNP -RRB- concentrations in very elderly heart_disease patients : specific geriatric cut-off and impacts of age , gender , renal_dysfunction , and nutritional status .
20456197	0	BNP	63,66	brain_natriuretic_peptide	36,61	BNP	brain natriuretic peptide	4879	4879	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	An obesity drug sibutramine reduces brain_natriuretic_peptide -LRB- BNP -RRB- levels in severely obese patients .
21340382	0	BNP	71,74	brain_natriuretic_peptide	44,69	BNP	brain natriuretic peptide	396844(Tax:9823)	396844(Tax:9823)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Pulmonary artery perfusion does not improve brain_natriuretic_peptide -LRB- BNP -RRB- levels in suine experimental research .
22368903	0	BNP	176,179	brain_natriuretic_peptide	149,174	BNP	brain natriuretic peptide	4879	4879	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The role of leukocyte counts in patients with unstable angina_pectoris or myocardial_infarction ; prognostic significance and correlation with plasma brain_natriuretic_peptide -LRB- BNP -RRB- levels .
2521447	0	BNP	48,51	brain_natriuretic_peptide	21,46	BNP	brain natriuretic peptide	4879	4879	Gene	Gene	detection|appos|START_ENTITY detection|amod|END_ENTITY	Radioimmunoassay for brain_natriuretic_peptide -LRB- BNP -RRB- detection of BNP in canine brain .
2521447	0	BNP	66,69	brain_natriuretic_peptide	21,46	BNP	brain natriuretic peptide	4879	4879	Gene	Gene	detection|nmod|START_ENTITY detection|amod|END_ENTITY	Radioimmunoassay for brain_natriuretic_peptide -LRB- BNP -RRB- detection of BNP in canine brain .
2525217	0	BNP	66,69	brain_natriuretic_peptide	39,64	BNP	brain natriuretic peptide	25105(Tax:10116)	25105(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Natriuretic and hypotensive effects of brain_natriuretic_peptide -LRB- BNP -RRB- in spontaneously hypertensive rats .
25932235	0	BNP	53,56	brain_type_natriuretic_peptide	21,51	BNP	brain type natriuretic peptide	4879	4879	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of serum brain_type_natriuretic_peptide -LRB- BNP -RRB- in patients with Crimean-Congo_hemorrhagic_fever .
17709512	0	BOB-1	34,39	ERdj3	18,23	BOB-1	ERdj3	5450	51726	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of ERdj3 and OBF-1 / BOB-1 / OCA-B as direct targets of XBP-1 during plasma cell differentiation .
26949185	0	BOK	0,3	BCL-2	23,28	BOK	BCL-2	666	596	Gene	Gene	Effector|nsubj|START_ENTITY Effector|compound|END_ENTITY	BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation .
26613676	0	BOLA2	44,49	Anamorsin	68,77	BOLA2	Anamorsin	552900	57019	Gene	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway .
15843967	0	BONZAI_1	60,68	COPINE_1	69,77	BONZAI 1	COPINE 1	836311(Tax:3702)	836311(Tax:3702)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Transgenic expression of the von_Willebrand A domain of the BONZAI_1 / COPINE_1 protein triggers a lesion-mimic phenotype in Arabidopsis .
15890826	0	BOP	0,3	MEF2C	95,100	BOP	MEF2C	12180(Tax:10090)	17260(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	BOP , a regulator of right ventricular heart development , is a direct transcriptional target of MEF2C in the developing heart .
12191639	0	BORIS	10,15	CTCF	18,22	BORIS	CTCF	140690	10664	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer .
22168535	0	BORIS	36,41	CTCFL	43,48	BORIS	CTCFL	140690	140690	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the epigenetic factor BORIS -LRB- CTCFL -RRB- in the human genome .
20231363	0	BORIS	134,139	Gal3st1	40,47	BORIS	Gal3st1	664799(Tax:10090)	53897(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of a testis-specific form of Gal3st1 -LRB- CST -RRB- , a gene essential for spermatogenesis , is regulated by the CTCF paralogous gene BORIS .
16140943	0	BORIS	69,74	MAGE-A1	136,143	BORIS	MAGE-A1	140690	4100	Gene	Gene	START_ENTITY|nmod|demethylation demethylation|nmod|END_ENTITY	Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes .
17957795	0	BORIS	14,19	MAGE-A1	58,65	BORIS	MAGE-A1	140690	4100	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|lack lack|nmod|association association|nmod|activation activation|compound|END_ENTITY	Expression of BORIS in melanoma : lack of association with MAGE-A1 activation .
25363021	0	BORIS	56,61	MAGE-A1	27,34	BORIS	MAGE-A1	140690	4100	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1 , both interacting with the TATA_binding_protein .
23329847	0	BOZF1	86,91	CDKN1A	61,67	BOZF1	CDKN1A	653121	1026	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Regulation of the cyclin-dependent kinase inhibitor 1A gene -LRB- CDKN1A -RRB- by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding .
1693321	0	BP-28	76,81	insulin-like_growth_factor-I	107,135	BP-28	insulin-like growth factor-I	474268	3479	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The growth hormone independent insulin-like_growth_factor-I binding protein BP-28 is associated with serum insulin-like_growth_factor-I inhibitory bioactivity in adolescent insulin-dependent diabetics .
8921417	0	BP-3	41,45	BST-1	35,40	BP-3	BST-1	12182(Tax:10090)	12182(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Stage-specific expression of mouse BST-1 / BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor .
20877436	0	BP1	0,3	BRCA1	59,64	BP1	BRCA1	474256	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BP1 , an isoform of DLX4 homeoprotein , negatively regulates BRCA1 in sporadic breast_cancer .
9638501	0	BP102	46,51	neutral_endopeptidase	13,34	BP102	neutral endopeptidase	369072(Tax:10116)	24590(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of a neutral_endopeptidase inhibitor , BP102 , on the development of deoxycorticosterone_acetate-salt hypertension in kininogen-deficient Brown Norway Katholiek rats .
15047159	0	BP8	81,84	CYP1A1	45,51	BP8	CYP1A1	326404(Tax:10116)	24296(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells .
11827295	0	BPA	28,31	bisphenol-A	15,26	BPA	bisphenol-A	667	667	Gene	Gene	Degradation|appos|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of bisphenol-A -LRB- BPA -RRB- in the presence of reactive oxygen species and its acceleration by lipids and sodium_chloride .
18967809	0	BPA	30,33	bisphenol_A	17,28	BPA	bisphenol A	667	667	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of bisphenol_A -LRB- BPA -RRB- in the presence of phenol by first-derivative fluorescence following micro liquid-liquid extraction -LRB- MLLE -RRB- .
7814399	0	BPAG1	104,109	230-kDa_bullous_pemphigoid_antigen	63,97	BPAG1	230-kDa bullous pemphigoid antigen	667	667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interferon-gamma-mediated inactivation of transcription of the 230-kDa_bullous_pemphigoid_antigen gene -LRB- BPAG1 -RRB- provides novel insight into keratinocyte differentiation .
8349819	0	BPAG1	50,55	bullous_pemphigoid_antigen	17,43	BPAG1	bullous pemphigoid antigen	667	667	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human 230-kD bullous_pemphigoid_antigen gene -LRB- BPAG1 -RRB- .
10504454	0	BPAG1	54,59	bullous_pemphigoid_antigen_1	24,52	BPAG1	bullous pemphigoid antigen 1	667	667	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of epidermal bullous_pemphigoid_antigen_1 -LRB- BPAG1 -RRB- synthesis by homeoprotein transcription factors .
26025051	0	BPC6	36,40	LHP1	65,69	BPC6	LHP1	834259(Tax:3702)	831635(Tax:3702)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The Arabidopsis GAGA-binding factor BPC6 recruits PRC1 component LHP1 to GAGA DNA-motifs .
15944398	0	BPGAP1	63,69	ERK1/2	43,49	BPGAP1	ERK1/2	23779	5595;5594	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain .
15064355	0	BPGAP1	0,6	cortactin	22,31	BPGAP1	cortactin	23779	2017	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration .
15506981	0	BPGAP1	43,49	cortactin	59,68	BPGAP1	cortactin	23779	2017	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|translocation translocation|compound|END_ENTITY	Filling the GAPs in cell dynamics control : BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration .
23742867	0	BPI	88,91	LBP	129,132	BPI	LBP	671	3929	Gene	Gene	analysis|appos|START_ENTITY /|nsubj|analysis /|dobj|lipopolysaccharide-binding_protein lipopolysaccharide-binding_protein|appos|END_ENTITY	Identification and expression analysis on bactericidal_permeability-increasing_protein -LRB- BPI -RRB- / lipopolysaccharide-binding_protein -LRB- LBP -RRB- of ark shell , Scapharca broughtonii .
7507806	0	BPI	63,66	LBP	108,111	BPI	LBP	671	3929	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Plasma levels of bactericidal/permeability-increasing _ protein -LRB- BPI -RRB- and lipopolysaccharide-binding protein -LRB- LBP -RRB- during hemodialysis .
8432532	0	BPI	113,116	LBP	54,57	BPI	LBP	671	3929	Gene	Gene	lipopolysaccharide_binding_protein|appos|START_ENTITY lipopolysaccharide_binding_protein|appos|END_ENTITY	The genes for the lipopolysaccharide_binding_protein -LRB- LBP -RRB- and the bactericidal_permeability_increasing_protein -LRB- BPI -RRB- are encoded in the same region of human chromosome 20 .
9240454	0	BPI	139,142	LBP	84,87	BPI	LBP	671	3929	Gene	Gene	lipopolysaccharide_binding_protein|appos|START_ENTITY lipopolysaccharide_binding_protein|appos|END_ENTITY	The genomic organization of the genes for human lipopolysaccharide_binding_protein -LRB- LBP -RRB- and bactericidal_permeability_increasing_protein -LRB- BPI -RRB- is highly conserved .
15896843	0	BPI	90,93	bactericidal_permeability-increasing_protein	44,88	BPI	bactericidal permeability-increasing protein	100304639(Tax:7998)	100304639(Tax:7998)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Characterization and expression analysis of bactericidal_permeability-increasing_protein -LRB- BPI -RRB- antimicrobial peptide gene from channel_catfish Ictalurus_punctatus .
23742867	0	BPI	88,91	bactericidal_permeability-increasing_protein	42,86	BPI	bactericidal permeability-increasing protein	671	671	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Identification and expression analysis on bactericidal_permeability-increasing_protein -LRB- BPI -RRB- / lipopolysaccharide-binding_protein -LRB- LBP -RRB- of ark shell , Scapharca broughtonii .
26646664	0	BPIFA1	51,57	Interleukin-13	0,14	BPIFA1	Interleukin-13	51297	3596	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells .
15284487	0	BPLF1	18,23	VP16	91,95	BPLF1	VP16	3783726(Tax:10376)	3054	Gene	Gene	START_ENTITY|dep|homologue homologue|nmod|END_ENTITY	The reading frame BPLF1 of Epstein-Barr_virus : a homologue of herpes simplex virus protein VP16 .
11401428	0	BPY_2	90,95	VCY2	84,88	BPY 2	VCY2	9083	9083	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization , physical mapping , and involvement in Yq microdeletions of the VCY2 -LRB- BPY_2 -RRB- gene .
12882447	0	BR22	0,4	TAP26	66,71	BR22	TAP26	29080	29080	Gene	Gene	START_ENTITY|appos|protein protein|appos|END_ENTITY	BR22 , a 26 kDa thyroid_transcription_factor-1 associated protein -LRB- TAP26 -RRB- , is expressed in human lung cells .
26373952	0	BRAF	41,45	ALK	47,50	BRAF	ALK	673	238	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26190239	0	BRAF	54,58	B-Raf_proto-oncogene	32,52	BRAF	B-Raf proto-oncogene	673	673	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Melanocytic nevi excised during B-Raf_proto-oncogene -LRB- BRAF -RRB- inhibitor therapy : A study of 19 lesions from 10 patients .
26073081	0	BRAF	36,40	BRAF	63,67	BRAF	BRAF	673	673	Gene	Gene	response|compound|START_ENTITY response|nmod|cells cells|compound|END_ENTITY	Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells .
26073081	0	BRAF	63,67	BRAF	36,40	BRAF	BRAF	673	673	Gene	Gene	cells|compound|START_ENTITY response|nmod|cells response|compound|END_ENTITY	Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells .
17018604	0	BRAF	71,75	CRAF	79,83	BRAF	CRAF	673	5894	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	In melanoma , RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic_AMP signaling .
22281684	0	BRAF	36,40	EGFR	90,94	BRAF	EGFR	673	1956	Gene	Gene	colon_cancer|nmod|START_ENTITY Unresponsiveness|nmod|colon_cancer inhibition|nsubj|Unresponsiveness inhibition|nmod|activation activation|nmod|END_ENTITY	Unresponsiveness of colon_cancer to BRAF -LRB- V600E -RRB- inhibition through feedback activation of EGFR .
22773810	0	BRAF	77,81	EGFR	41,45	BRAF	EGFR	673	1956	Gene	Gene	mutations|amod|START_ENTITY harbor|dobj|mutations harbor|nsubj|Lung_cancers Lung_cancers|nmod|resistance resistance|nmod|inhibitors inhibitors|amod|END_ENTITY	Lung_cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS , NRAS , or MEK1 .
23224067	0	BRAF	20,24	EGFR	26,30	BRAF	EGFR	673	1956	Gene	Gene	affecting|dobj|START_ENTITY associated|advcl|affecting associated|nsubjpass|END_ENTITY	Mutations affecting BRAF , EGFR , PIK3CA , and KRAS are not associated with sporadic vestibular_schwannomas .
24594201	0	BRAF	32,36	EGFR	20,24	BRAF	EGFR	673	1956	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
25153497	0	BRAF	69,73	EGFR	49,53	BRAF	EGFR	673	1956	Gene	Gene	Genes|appos|START_ENTITY Genes|compound|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
25243790	0	BRAF	53,57	EGFR	22,26	BRAF	EGFR	673	1956	Gene	Gene	Cutaneous_Melanomas|compound|START_ENTITY Role|nmod|Cutaneous_Melanomas Have|dobj|Role Have|nsubj|Changes Changes|nmod|END_ENTITY	Epigenetic Changes of EGFR Have an Important Role in BRAF Inhibitor-Resistant Cutaneous_Melanomas .
25556681	0	BRAF	66,70	EGFR	108,112	BRAF	EGFR	673	1956	Gene	Gene	mutation|compound|START_ENTITY mutation|nmod|lung_adenocarcinoma lung_adenocarcinoma|nmod|mutation mutation|amod|END_ENTITY	Tumour-to-tumour metastasis from papillary_thyroid_carcinoma with BRAF mutation to lung_adenocarcinoma with EGFR mutation : the utility of mutation-specific antibodies .
25749811	0	BRAF	104,108	EGFR	33,37	BRAF	EGFR	673	1956	Gene	Gene	Influenced|nmod|START_ENTITY Influenced|nsubj|Sensitivity Sensitivity|nmod|Cells Cells|nmod|Activation Activation|compound|END_ENTITY	Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations .
26341080	0	BRAF	20,24	EGFR	38,42	BRAF	EGFR	673	1956	Gene	Gene	Number|compound|START_ENTITY Number|appos|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26373952	0	BRAF	41,45	EGFR	29,33	BRAF	EGFR	673	1956	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|compound|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26842788	0	BRAF	81,85	EGFR	69,73	BRAF	EGFR	673	1956	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|compound|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
15184373	0	BRAF	107,111	ERK	59,62	BRAF	ERK	673	5594	Gene	Gene	mutation|compound|START_ENTITY role|nmod|mutation cells|dep|role mediated|nmod|cells mediated|nmod|pathway pathway|compound|END_ENTITY	Overexpression of collagenase 1 -LRB- MMP-1 -RRB- is mediated by the ERK pathway in invasive melanoma cells : role of BRAF mutation and fibroblast growth factor signaling .
20149136	0	BRAF	21,25	ERK	65,68	BRAF	ERK	673	5594	Gene	Gene	inhibitor|compound|START_ENTITY PLX4032|appos|inhibitor activates|nsubj|PLX4032 activates|dobj|pathway pathway|compound|END_ENTITY	PLX4032 , a selective BRAF -LRB- V600E -RRB- kinase inhibitor , activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells .
23544999	0	BRAF	74,78	ERK	0,3	BRAF	ERK	673	5594	Gene	Gene	mutation|compound|START_ENTITY papillary_thyroid_carcinomas|nmod|mutation increased|nmod|papillary_thyroid_carcinomas increased|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	ERK phosphorylation is not increased in papillary_thyroid_carcinomas with BRAF -LRB- V600E -RRB- mutation compared to that of corresponding normal thyroid tissues .
23614898	0	BRAF	85,89	ERK	21,24	BRAF	ERK	673	5594	Gene	Gene	resistance|nmod|START_ENTITY models|nmod|resistance activity|nmod|models inhibitor|nmod|activity inhibitor|compound|END_ENTITY	Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors .
23749901	0	BRAF	93,97	ERK	86,89	BRAF	ERK	673	5594	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon_cancer cells .
25142146	0	BRAF	58,62	ERK	26,29	BRAF	ERK	673	5594	Gene	Gene	mutant|compound|START_ENTITY activity|nmod|mutant activity|nmod|SCH722984 SCH722984|compound|END_ENTITY	Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant , NRAS mutant and wild-type melanoma .
25329694	0	BRAF	0,4	ERK	26,29	BRAF	ERK	673	2048	Gene	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	BRAF inhibitor-associated ERK activation drives development of chronic_lymphocytic_leukemia .
26134498	0	BRAF	70,74	ERK	38,41	BRAF	ERK	673	5594	Gene	Gene	mutant|compound|START_ENTITY SCH722984|nmod|mutant SCH722984|compound|END_ENTITY	Erratum to : Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant , NRAS mutant and wild-type melanoma .
26065894	0	BRAF	67,71	Epidermal_Growth_Factor_Receptor	84,116	BRAF	Epidermal Growth Factor Receptor	673	1956	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Mitogen-Inducible_Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal_Growth_Factor_Receptor and Thereby Limits Malignant Transformation .
20012784	0	BRAF	11,15	HRAS	29,33	BRAF	HRAS	673	3265	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
22294102	0	BRAF	73,77	HRAS	23,27	BRAF	HRAS	673	3265	Gene	Gene	genes|compound|START_ENTITY mutations|nmod|genes gene|nmod|mutations gene|compound|END_ENTITY	Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral_squamous_cell_carcinoma in a Greek population .
26165597	0	BRAF	32,36	HRAS	125,129	BRAF	HRAS	673	3265	Gene	Gene	Kinase|compound|START_ENTITY Domain|nmod|Kinase Exhibits|nsubj|Domain Exhibits|nmod|END_ENTITY	The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS .
21340604	0	BRAF	18,22	IGF1R	30,35	BRAF	IGF1R	673	3480	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
25382612	0	BRAF	9,13	KIAA1549	0,8	BRAF	KIAA1549	673	57670	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	KIAA1549 : BRAF fusion gene in pediatric brain_tumors of various histogenesis .
26083571	0	BRAF	10,14	KIAA1549	0,8	BRAF	KIAA1549	673	57670	Gene	Gene	Fusion|compound|START_ENTITY END_ENTITY|dep|Fusion	KIAA1549 : BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic_Astrocytomas .
16144912	0	BRAF	0,4	KRAS	73,77	BRAF	KRAS	673	3845	Gene	Gene	mutation|compound|START_ENTITY mutation|dep|correlation correlation|nmod|END_ENTITY	BRAF mutation in endometrial_carcinoma and hyperplasia : correlation with KRAS and p53 mutations and mismatch repair protein expression .
16256179	0	BRAF	22,26	KRAS	80,84	BRAF	KRAS	673	3845	Gene	Gene	absence|nmod|START_ENTITY mutations|nsubj|absence mutations|nmod|status status|compound|END_ENTITY	Consistent absence of BRAF mutations in cervical and endometrial_cancer despite KRAS mutation status .
19087308	0	BRAF	56,60	KRAS	32,36	BRAF	KRAS	673	3845	Gene	Gene	context|compound|START_ENTITY expression|nmod|context expression|nmod|G12D G12D|compound|END_ENTITY	Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context .
20012784	0	BRAF	11,15	KRAS	23,27	BRAF	KRAS	673	3845	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
20627194	0	BRAF	180,184	KRAS	126,130	BRAF	KRAS	114486(Tax:10116)	24525(Tax:10116)	Gene	Gene	V-raf_murine_sarcoma_viral_oncogene_homolog_B1|appos|START_ENTITY V-raf_murine_sarcoma_viral_oncogene_homolog_B1|amod|V-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog V-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog|dep|END_ENTITY	Cycleave polymerase chain reaction method is practically applicable for V-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog -LRB- KRAS -RRB- / V-raf_murine_sarcoma_viral_oncogene_homolog_B1 -LRB- BRAF -RRB- genotyping in colorectal_cancer .
21163703	0	BRAF	6,10	KRAS	0,4	BRAF	KRAS	673	3845	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|compound|END_ENTITY	KRAS , BRAF , PIK3CA , and PTEN mutations : implications for targeted therapies in metastatic colorectal_cancer .
21340604	0	BRAF	18,22	KRAS	12,16	BRAF	KRAS	673	3845	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
22938585	0	BRAF	94,98	KRAS	87,91	BRAF	KRAS	673	3845	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|compound|END_ENTITY	High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in formalin-fixed , paraffin-embedded tissues .
23585181	0	BRAF	15,19	KRAS	27,31	BRAF	KRAS	673	3845	Gene	Gene	NRAS|compound|START_ENTITY Application|nmod|NRAS END_ENTITY|nsubj|Application	Application of BRAF , NRAS , KRAS mutations as markers for the detection of papillary thyroid_cancer from FNAB specimens by pyrosequencing analysis .
24549645	0	BRAF	14,18	KRAS	0,4	BRAF	KRAS	673	3845	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	KRAS -LRB- but not BRAF -RRB- mutations in ovarian_serous_borderline_tumour are associated with recurrent low-grade serous_carcinoma .
24594201	0	BRAF	32,36	KRAS	26,30	BRAF	KRAS	673	3845	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
24861115	0	BRAF	1,5	KRAS	33,37	BRAF	KRAS	673	3845	Gene	Gene	mutation|compound|START_ENTITY mutation|nmod|patients patients|compound|END_ENTITY	-LSB- BRAF gene mutation in wild-type KRAS patients with colorectal_cancers -RSB- .
25153497	0	BRAF	69,73	KRAS	55,59	BRAF	KRAS	673	3845	Gene	Gene	Genes|appos|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
26004768	4	BRAF	1082,1086	KRAS	1076,1080	NRAS	KRAS	4893	3845	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26325103	0	BRAF	12,16	KRAS	0,4	BRAF	KRAS	673	3845	Gene	Gene	comparison|amod|START_ENTITY END_ENTITY|appos|comparison	KRAS , NRAS , BRAF mutation comparison of endoscopic and surgically removed primary CRC paired samples : is endoscopy biopsy material adequate for molecular evaluation ?
26341080	0	BRAF	20,24	KRAS	108,112	BRAF	KRAS	673	3845	Gene	Gene	Number|compound|START_ENTITY Value|nmod|Number Value|nmod|Patients Patients|nmod|Chemotherapy Chemotherapy|compound|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26352110	0	BRAF	12,16	KRAS	0,4	BRAF	KRAS	673	3845	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	KRAS , NRAS , BRAF mutations and high counts of poorly_differentiated_clusters of neoplastic cells in colorectal_cancer : observational analysis of 175 cases .
26373952	0	BRAF	41,45	KRAS	35,39	BRAF	KRAS	673	3845	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26842788	0	BRAF	81,85	KRAS	75,79	BRAF	KRAS	673	3845	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
26991109	0	BRAF	0,4	KRAS	58,62	BRAF	KRAS	673	3845	Gene	Gene	PIK3CA|compound|START_ENTITY Alterations|nsubj|PIK3CA Alterations|nmod|Status Status|compound|END_ENTITY	BRAF , PIK3CA , and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal_Cancers with Distant Metastasis .
26991344	0	BRAF	16,20	KRAS	10,14	BRAF	KRAS	673	3845	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|compound|END_ENTITY	Impact of KRAS , BRAF , PIK3CA , TP53 status and intra-individual mutation heterogeneity on outcome after liver resection for colorectal_cancer metastases .
26457492	0	BRAF	194,198	KRas	200,204	BRAF	KRas	673	3845	Gene	Gene	START_ENTITY|appos|oraz oraz|compound|END_ENTITY	Frequency assessment of BRAF mutation , KRas mutation , and RASSF1A methylation in nodular_goitre based on fine-needle aspiration cytology specimens Ocena cz sto ci wyst powania mutacji gen w BRAF , KRas oraz .
26457492	0	BRAF	24,28	KRas	200,204	BRAF	KRas	673	3845	Gene	Gene	mutation|compound|START_ENTITY assessment|nmod|mutation gen|nsubj|assessment gen|dobj|BRAF BRAF|appos|oraz oraz|compound|END_ENTITY	Frequency assessment of BRAF mutation , KRas mutation , and RASSF1A methylation in nodular_goitre based on fine-needle aspiration cytology specimens Ocena cz sto ci wyst powania mutacji gen w BRAF , KRas oraz .
18628967	0	BRAF	10,14	MITF	84,88	BRAF	MITF	673	4286	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF .
26829212	0	BRAF	51,55	MKP-1	82,87	BRAF	MKP-1	673	1843	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1 .
24118207	0	BRAF	10,14	Mcl-1	36,41	BRAF	Mcl-1	673	4170	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic_melanoma .
25873592	0	BRAF	83,87	Mcl-1	132,137	BRAF	Mcl-1	673	4170	Gene	Gene	Inhibitor|compound|START_ENTITY Resistance|nsubj|Inhibitor Resistance|nmod|Suppression Suppression|nmod|END_ENTITY	The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression .
24752710	0	BRAF	38,42	MicroRNA-31	0,11	BRAF	MicroRNA-31	673	407035	Gene	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	MicroRNA-31 expression in relation to BRAF mutation , CpG island methylation and colorectal continuum in serrated lesions .
26065894	0	BRAF	67,71	Mitogen-Inducible_Gene-6	0,24	BRAF	Mitogen-Inducible Gene-6	673	54206	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Mitogen-Inducible_Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal_Growth_Factor_Receptor and Thereby Limits Malignant Transformation .
16888631	0	BRAF	68,72	NRAS	46,50	BRAF	NRAS	673	4893	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|mutations mutations|compound|END_ENTITY	Congenital melanocytic_nevi frequently harbor NRAS mutations but no BRAF mutations .
18679422	6	BRAF	1061,1065	NRAS	1170,1174	NRAS	BRAF	4893	673	Gene	Gene	inhibition|nmod|START_ENTITY suppressed|nmod|inhibition p16|parataxis|suppressed p16|advcl|inhibition inhibition|dep|END_ENTITY	These senescence phenotypes were p16 -LRB- INK4A -RRB- - or p53-independent , however , several of them were suppressed by genetic or pharmacological inhibition of BRAF -LRB- V600E -RRB- or phosphoinositide 3-kinase pathways , including rapamycin-mediated inhibition of mTOR-raptor in NRAS -LRB- Q61R -RRB- - expressing melanoma cells .
19492075	0	BRAF	22,26	NRAS	99,103	BRAF	NRAS	109880(Tax:10090)	18176(Tax:10090)	Gene	Gene	Combined|nmod|START_ENTITY required|nsubjpass|Combined required|nmod|efficacy efficacy|nmod|tumors tumors|compound|END_ENTITY	Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors .
20012784	0	BRAF	11,15	NRAS	17,21	BRAF	NRAS	673	4893	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
22389471	0	BRAF	16,20	NRAS	138,142	BRAF	NRAS	673	4893	Gene	Gene	Combinations|nmod|START_ENTITY inhibitors|nsubj|Combinations inhibitors|xcomp|overcome overcome|nmod|dabrafenib dabrafenib|acl|mediated mediated|nmod|mutations mutations|compound|END_ENTITY	Combinations of BRAF , MEK , and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib , mediated by NRAS or MEK mutations .
22389471	0	BRAF	88,92	NRAS	138,142	BRAF	NRAS	673	4893	Gene	Gene	dabrafenib|compound|START_ENTITY dabrafenib|acl|mediated mediated|nmod|mutations mutations|compound|END_ENTITY	Combinations of BRAF , MEK , and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib , mediated by NRAS or MEK mutations .
23666916	0	BRAF	108,112	NRAS	96,100	BRAF	NRAS	673	4893	Gene	Gene	KRAS|dep|START_ENTITY KRAS|dep|END_ENTITY	FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type -LRB- KRAS , NRAS , HRAS , BRAF -RRB- metastatic colorectal_cancer patients : a phase II trial by the Gruppo Oncologico Nord Ovest -LRB- GONO -RRB- .
25063807	0	BRAF	132,136	NRAS	69,73	BRAF	NRAS	673	4893	Gene	Gene	cells|compound|START_ENTITY acquired|nmod|cells END_ENTITY|ccomp|acquired	Mitogen-activated protein kinase -LRB- MAPK -RRB- hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells .
25343173	0	BRAF	137,141	NRAS	120,124	BRAF	NRAS	673	4893	Gene	Gene	Exons|compound|START_ENTITY Mutation|nmod|Exons Mutation|compound|END_ENTITY	Increased Levels of b-catenin , LEF-1 , and HPA-1 Correlate with Poor Prognosis for Acral_Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2 .
26004768	4	BRAF	1082,1086	NRAS	1088,1092	NRAS	BRAF	4893	673	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26134498	0	BRAF	70,74	NRAS	83,87	BRAF	NRAS	673	4893	Gene	Gene	mutant|compound|START_ENTITY SCH722984|nmod|mutant activity|nmod|SCH722984 activity|appos|mutant mutant|compound|END_ENTITY	Erratum to : Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant , NRAS mutant and wild-type melanoma .
26204954	0	BRAF	14,18	NRAS	0,4	BRAF	NRAS	673	4893	Gene	Gene	immunohistochemistry|amod|START_ENTITY END_ENTITY|appos|immunohistochemistry	NRAS -LRB- Q61R -RRB- , BRAF -LRB- V600E -RRB- immunohistochemistry : a concomitant tool for mutation screening in melanomas .
26204954	0	BRAF	14,18	NRAS	0,4	BRAF	NRAS	673	4893	Gene	Gene	immunohistochemistry|amod|START_ENTITY END_ENTITY|appos|immunohistochemistry	NRAS -LRB- Q61R -RRB- , BRAF -LRB- V600E -RRB- immunohistochemistry : a concomitant tool for mutation screening in melanomas .
26325103	0	BRAF	12,16	NRAS	6,10	BRAF	NRAS	673	4893	Gene	Gene	comparison|amod|START_ENTITY KRAS|appos|comparison KRAS|appos|END_ENTITY	KRAS , NRAS , BRAF mutation comparison of endoscopic and surgically removed primary CRC paired samples : is endoscopy biopsy material adequate for molecular evaluation ?
26352110	0	BRAF	12,16	NRAS	6,10	BRAF	NRAS	673	4893	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	KRAS , NRAS , BRAF mutations and high counts of poorly_differentiated_clusters of neoplastic cells in colorectal_cancer : observational analysis of 175 cases .
25153497	0	BRAF	69,73	PIK3CA	61,67	BRAF	PIK3CA	673	5290	Gene	Gene	Genes|appos|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
25627962	0	BRAF	41,45	PIK3CA	11,17	BRAF	PIK3CA	673	5290	Gene	Gene	mutations|compound|START_ENTITY coexist|nmod|mutations coexist|nsubj|mutations mutations|compound|END_ENTITY	Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas .
25714871	0	BRAF	53,57	PIK3CA	120,126	BRAF	PIK3CA	673	5290	Gene	Gene	V600E|compound|START_ENTITY Associated|nmod|V600E E17K|nmod|Associated E17K|dep|Comparison Comparison|nmod|Helical Helical|compound|END_ENTITY	AKT1 E17K in Colorectal_Carcinoma Is Associated with BRAF V600E but Not MSI-H Status : A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants .
26004768	4	BRAF	1082,1086	PIK3CA	1094,1100	NRAS	PIK3CA	4893	5290	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26373952	0	BRAF	41,45	PIK3CA	52,58	BRAF	PIK3CA	673	5290	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
21340604	0	BRAF	18,22	PTEN	24,28	BRAF	PTEN	673	5728	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
21725359	0	BRAF	110,114	PTEN	23,27	BRAF	PTEN	673	5728	Gene	Gene	dependence|nmod|START_ENTITY attenuates|dobj|dependence attenuates|nsubj|loss loss|nmod|END_ENTITY	Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring -LRB- V600E -RRB- BRAF .
24594201	0	BRAF	32,36	PTEN	38,42	BRAF	PTEN	673	5728	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
26341080	0	BRAF	20,24	PTEN	32,36	BRAF	PTEN	673	5728	Gene	Gene	Number|compound|START_ENTITY Number|appos|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
25010701	0	BRAF	32,36	SOX2	0,4	BRAF	SOX2	673	6657	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal_cancer .
21134562	0	BRAF	33,37	Spry2	0,5	BRAF	Spry2	673	10253	Gene	Gene	mutation|compound|START_ENTITY correlates|nmod|mutation correlates|nsubj|expression expression|amod|END_ENTITY	Spry2 expression correlates with BRAF mutation in thyroid_cancer .
26003825	0	BRAF	78,82	THRb	22,26	BRAF	THRb	673	7068	Gene	Gene	expression|compound|START_ENTITY relationship|nmod|expression expression|dep|relationship expression|nmod|END_ENTITY	Reduced expression of THRb in papillary_thyroid_carcinomas : relationship with BRAF mutation , aggressiveness and miR expression .
17001349	0	BRAF	10,14	beta-Trcp	25,34	BRAF	beta-Trcp	673	8945	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells .
17409425	0	BRAF	13,17	hypoxia_inducible_factor-1alpha	28,59	BRAF	hypoxia inducible factor-1alpha	673	3091	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Mutant V600E BRAF increases hypoxia_inducible_factor-1alpha expression in melanoma .
15651028	0	BRAK	22,26	CXCL14	14,20	BRAK	CXCL14	9547	9547	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Modulation of CXCL14 -LRB- BRAK -RRB- expression in prostate_cancer .
19673887	0	BRAK	15,19	CXCL14	22,28	BRAK	CXCL14	9547	9547	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Restoration of BRAK / CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head_and_neck_squamous_cell_carcinoma .
21978833	0	BRAK	36,40	CXCL14	28,34	BRAK	CXCL14	57266(Tax:10090)	57266(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Neutralization of chemokine CXCL14 -LRB- BRAK -RRB- expression reduces CCl4 induced liver_injury and steatosis in mice .
15319482	0	BRASSINOSTEROID-INSENSITIVE_1	71,100	transthyretin-like_protein	16,42	BRASSINOSTEROID-INSENSITIVE 1	transthyretin-like protein	830095(Tax:3702)	835934(Tax:3702)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The Arabidopsis transthyretin-like_protein is a potential substrate of BRASSINOSTEROID-INSENSITIVE_1 .
25657994	0	BRAT1	56,61	BRCA1-Associated_ATM_Activator-1	22,54	BRAT1	BRCA1-Associated ATM Activator-1	231841(Tax:10090)	231841(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Potential Role of BRCA1-Associated_ATM_Activator-1 -LRB- BRAT1 -RRB- in Regulation of mTOR .
26773365	0	BRB	31,34	brain_ribonuclease	11,29	BRB	brain ribonuclease	280720(Tax:9913)	280720(Tax:9913)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in brain_ribonuclease -LRB- BRB -RRB- messenger RNA in granulosa cells -LRB- GCs -RRB- of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs .
10542266	0	BRCA1	37,42	AKT	81,84	BRCA1	AKT	672	207	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nmod|END_ENTITY	Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol_3-Kinase / AKT in breast_cancer cells .
20177704	0	BRCA1	20,25	ATM	27,30	BRCA1	ATM	672	472	Gene	Gene	PIK3CA|compound|START_ENTITY PIK3CA|appos|END_ENTITY	Alterations in p53 , BRCA1 , ATM , PIK3CA , and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast_cancer .
24058603	0	BRCA1	20,25	ATP7B	34,39	BRCA1	ATP7B	672	540	Gene	Gene	TOPOI|compound|START_ENTITY TOPOI|appos|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
16452194	0	BRCA1	63,68	Ataxia_telangiectasia_mutated	0,29	BRCA1	Ataxia telangiectasia mutated	672	472	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Ataxia_telangiectasia_mutated and checkpoint_kinase_2 regulate BRCA1 to promote the fidelity of DNA end-joining .
11301010	0	BRCA1	62,67	BACH1	0,5	BRCA1	BACH1	672	571	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BACH1 , a novel helicase-like protein , interacts directly with BRCA1 and contributes to its DNA repair function .
11920628	0	BRCA1	34,39	BACH1	20,25	BRCA1	BACH1	672	571	Gene	Gene	families|compound|START_ENTITY gene|nmod|families gene|compound|END_ENTITY	No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22 .
15125843	0	BRCA1	33,38	BACH1	50,55	BRCA1	BACH1	672	571	Gene	Gene	START_ENTITY|acl|bound bound|nmod|phosphopeptide phosphopeptide|compound|END_ENTITY	Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide : implications for signaling .
15133502	0	BRCA1	27,32	BACH1	75,80	BRCA1	BACH1	672	571	Gene	Gene	Structure|nmod|START_ENTITY BRCT|nsubj|Structure BRCT|dobj|recognition recognition|nmod|END_ENTITY	Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer .
15242590	0	BRCA1	56,61	BACH1	20,25	BRCA1	BACH1	672	571	Gene	Gene	domains|compound|START_ENTITY phosphopeptide|nmod|domains phosphopeptide|nsubj|basis basis|nmod|END_ENTITY	Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains .
11773071	0	BRCA1	70,75	BARD1	59,64	BRCA1	BRCA1	672	672	Gene	Gene	required|nmod|START_ENTITY required|nmod|interaction interaction|nmod|END_ENTITY	Identification of residues required for the interaction of BARD1 with BRCA1 .
14976165	0	BRCA1	0,5	BARD1	8,13	BRCA1	BARD1	672	580	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures , dependent on K6 of ubiquitin , in cells during DNA replication and repair .
15265711	0	BRCA1	16,21	BARD1	0,5	BRCA1	BARD1	672	580	Gene	Gene	function|nummod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention .
20877436	0	BRCA1	59,64	BP1	0,3	BRCA1	BP1	672	474256	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BP1 , an isoform of DLX4 homeoprotein , negatively regulates BRCA1 in sporadic breast_cancer .
22426855	0	BRCA1	0,5	BRCA1	64,69	BRCA1	BRCA1	672	672	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	BRCA1 -- conductor of the breast stem cell orchestra : the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast_cancer .
22426855	0	BRCA1	64,69	BRCA1	0,5	BRCA1	BRCA1	672	672	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	BRCA1 -- conductor of the breast stem cell orchestra : the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast_cancer .
10505028	0	BRCA1	21,26	BRCA2	82,87	BRCA1	BRCA2	672	675	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|3414del4 3414del4|compound|END_ENTITY	Mutation analysis of BRCA1 and BRCA2 in Turkish cancer families : a novel mutation BRCA2 3414del4 found in male_breast_cancer .
10790213	0	BRCA1	8,13	BRCA2	47,52	BRCA1	BRCA2	672	675	Gene	Gene	mutations|compound|START_ENTITY germline|nsubj|mutations germline|dobj|mutations mutations|nummod|END_ENTITY	Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast_and / or_ovarian_cancer families from North-Eastern Poland .
10818594	0	BRCA1	29,34	BRCA2	36,41	BRCA1	BRCA2	672	675	Gene	Gene	K-ras|nummod|START_ENTITY K-ras|nummod|END_ENTITY	Mutation detection in K-ras , BRCA1 , BRCA2 , and p53 using PCR/LDR and a universal DNA microarray .
11391658	0	BRCA1	61,66	BRCA2	84,89	BRCA1	BRCA2	672	675	Gene	Gene	2594delC|nmod|START_ENTITY 2594delC|nmod|gene gene|compound|END_ENTITY	Caucasian family with two independent mutations : 2594delC in BRCA1 and 5392delAG in BRCA2 gene .
12125210	0	BRCA1	22,27	BRCA2	43,48	BRCA1	BRCA2	672	675	Gene	Gene	5382insC|appos|START_ENTITY 5382insC|appos|END_ENTITY	Analysis of 5382insC -LRB- BRCA1 -RRB- and 6174delT -LRB- BRCA2 -RRB- mutations in 382 healthy Chilean women with a family history of breast_cancer .
12142080	0	BRCA1	10,15	BRCA2	18,23	BRCA1	BRCA2	672	675	Gene	Gene	_|nsubj|START_ENTITY _|dobj|mutations mutations|nummod|END_ENTITY	Germ line BRCA1 _ BRCA2 mutations in Greek breast/ovarian _ cancer families : 5382insC is the most frequent mutation observed .
12673274	0	BRCA1	58,63	BRCA2	80,85	BRCA1	BRCA2	672	675	Gene	Gene	3358T/A|nmod|START_ENTITY 3358T/A|nmod|genes genes|nummod|END_ENTITY	Italian family with two independent mutations : 3358T/A in BRCA1 and 8756delA in BRCA2 genes .
17289874	0	BRCA1	67,72	BRCA2	74,79	BRCA1	BRCA2	672	675	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Epigenetic inactivation of the chromosomal stability control genes BRCA1 , BRCA2 , and XRCC5 in non-small cell lung_cancer .
17307353	0	BRCA1	97,102	BRCA2	89,94	BRCA1	BRCA2	672	675	Gene	Gene	START_ENTITY|nsubj|characteristics characteristics|appos|factors factors|nmod|hereditary_breast_cancer hereditary_breast_cancer|nmod|END_ENTITY	Tumour characteristics , survival and prognostic factors of hereditary_breast_cancer from BRCA2 - , BRCA1 - and non-BRCA1 / 2 families as compared to sporadic_breast_cancer cases .
17341484	0	BRCA1	44,49	BRCA2	51,56	BRCA1	BRCA2	672	675	Gene	Gene	variants|nmod|START_ENTITY predicts|nmod|variants predicts|nsubj|END_ENTITY	Counting potentially functional variants in BRCA1 , BRCA2 and ATM predicts breast_cancer susceptibility .
17428325	0	BRCA1	28,33	BRCA2	35,40	BRCA1	BRCA2	672	675	Gene	Gene	ATM|nummod|START_ENTITY ATM|nummod|END_ENTITY	Common variants in the ATM , BRCA1 , BRCA2 , CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast_cancer risk .
17624602	0	BRCA1	0,5	BRCA2	7,12	BRCA1	BRCA2	672	675	Gene	Gene	germline|advmod|START_ENTITY germline|nsubj|END_ENTITY	BRCA1 , BRCA2 , TP53 , and CDKN2A germline mutations in patients with breast_cancer and cutaneous_melanoma .
18429825	0	BRCA1	44,49	BRCA2	51,56	BRCA1	BRCA2	672	675	Gene	Gene	polymorphisms|nmod|START_ENTITY END_ENTITY|nsubj|polymorphisms	Dinucleotide repeat polymorphisms of RAD51 , BRCA1 , BRCA2 gene regions in breast_cancer .
18559571	0	BRCA1	57,62	BRCA2	37,42	BRCA1	BRCA2	672	675	Gene	Gene	mutations|nummod|START_ENTITY END_ENTITY|nmod|mutations	Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian_cancer .
19189213	0	BRCA1	90,95	BRCA2	49,54	BRCA1	BRCA2	672	675	Gene	Gene	not|nmod|START_ENTITY breast_tumors|dep|not breast_tumors|nummod|END_ENTITY	Frequent somatic mutations of GATA3 in non-BRCA1 / BRCA2 familial breast_tumors , but not in BRCA1 - , BRCA2 - or sporadic breast_tumors .
19189213	0	BRCA1	90,95	BRCA2	98,103	BRCA1	BRCA2	672	675	Gene	Gene	not|nmod|START_ENTITY breast_tumors|dep|not breast_tumors|amod|END_ENTITY	Frequent somatic mutations of GATA3 in non-BRCA1 / BRCA2 familial breast_tumors , but not in BRCA1 - , BRCA2 - or sporadic breast_tumors .
19372713	0	BRCA1	68,73	BRCA2	75,80	BRCA1	BRCA2	672	675	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Age at onset of bilateral_breast_cancer , the presence of hereditary BRCA1 , BRCA2 , CHEK2 gene mutations and positive family history of cancer .
19649760	0	BRCA1	44,49	BRCA2	52,57	BRCA1	BRCA2	672	675	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Clinical and pathologic differences between BRCA1 - , BRCA2 - , and non-BRCA-associated breast_cancers in a multiracial developing country .
20676756	0	BRCA1	81,86	BRCA2	108,113	BRCA1	BRCA2	672	675	Gene	Gene	BRCA2|compound|START_ENTITY families|compound|BRCA2 families|compound|END_ENTITY	Prevalence of the variant allele rs61764370 T > G in the 3 ` UTR of KRAS among Dutch BRCA1 , BRCA2 and non-BRCA1 / BRCA2 breast_cancer families .
21356067	0	BRCA1	14,19	BRCA2	21,26	BRCA1	BRCA2	672	675	Gene	Gene	RAD50|compound|START_ENTITY RAD50|appos|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
22113258	0	BRCA1	41,46	BRCA2	47,52	BRCA1	BRCA2	672	675	Gene	Gene	families|compound|START_ENTITY families|compound|END_ENTITY	Phenocopy breast_cancer rates in Israeli BRCA1 BRCA2 mutation carrier families : is the risk increased in non-carriers ?
22348646	0	BRCA1	103,108	BRCA2	116,121	BRCA1	BRCA2	672	675	Gene	Gene	carriers|compound|START_ENTITY carriers|compound|END_ENTITY	Common variants at 12p11 , 12q24 , 9p21 , 9q31 .2 and in ZNF365 are associated with breast_cancer risk for BRCA1 and/or BRCA2 mutation carriers .
22964643	0	BRCA1	64,69	BRCA2	95,100	BRCA1	BRCA2	672	675	Gene	Gene	deficiencies|nmod|START_ENTITY lethal|nmod|deficiencies lethal|xcomp|END_ENTITY	RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination .
25356972	0	BRCA1	0,5	BRCA2	7,12	BRCA1	BRCA2	672	675	Gene	Gene	PALB2|compound|START_ENTITY PALB2|appos|END_ENTITY	BRCA1 , BRCA2 , PALB2 , and CDKN2A mutations in familial pancreatic_cancer : a PACGENE study .
25673166	0	BRCA1	36,41	BRCA2	44,49	BRCA1	BRCA2	672	675	Gene	Gene	carriers|compound|START_ENTITY carriers|compound|END_ENTITY	Breast_cancer detection among Irish BRCA1 _ BRCA2 mutation carriers : a population-based study .
27068824	0	BRCA1	15,20	BRCA2	22,27	BRCA1	BRCA2	672	675	Gene	Gene	RAD51|compound|START_ENTITY RAD51|dep|END_ENTITY	Association of BRCA1 , BRCA2 , RAD51 , and HER2 gene polymorphisms with the breast_cancer risk in the Bangladeshi population .
9042909	0	BRCA1	47,52	BRCA2	69,74	BRCA1	BRCA2	672	675	Gene	Gene	185delAG|nmod|START_ENTITY 185delAG|nmod|END_ENTITY	The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60 % of ovarian_cancer and 30 % of early-onset breast_cancer patients among Ashkenazi women .
9150150	0	BRCA1	212,217	BRCA2	0,5	BRCA1	BRCA2	672	675	Gene	Gene	attributable|nmod|START_ENTITY families|acl:relcl|attributable mutations|nmod|families END_ENTITY|dep|mutations	BRCA2 in American families with four or more cases of breast or ovarian_cancer : recurrent and novel mutations , variable expression , penetrance , and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2 .
9743298	0	BRCA1	36,41	BRCA2	76,81	BRCA1	BRCA2	672	675	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate_cancer .
20215511	0	BRCA1	56,61	BRD7	0,4	BRCA1	BRD7	672	29117	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	BRD7 , a subunit of SWI/SNF complexes , binds directly to BRCA1 and regulates BRCA1-dependent transcription .
21356067	0	BRCA1	14,19	BRIP1	42,47	BRCA1	BRIP1	672	83990	Gene	Gene	RAD50|compound|START_ENTITY RAD50|appos|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
18514188	0	BRCA1	135,140	Breast_Cancer_Susceptibility_gene-1	98,133	BRCA1	Breast Cancer Susceptibility gene-1	672	672	Gene	Gene	status|appos|START_ENTITY status|compound|END_ENTITY	Genistein induces apoptosis in ovarian_cancer cells via different molecular pathways depending on Breast_Cancer_Susceptibility_gene-1 -LRB- BRCA1 -RRB- status .
17643121	0	BRCA1	15,20	CCDC98	0,6	BRCA1	CCDC98	672	84142	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	CCDC98 targets BRCA1 to DNA damage sites .
26300001	0	BRCA1	61,66	CEP72	22,27	BRCA1	CEP72	672	55722	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability .
19372713	0	BRCA1	68,73	CHEK2	82,87	BRCA1	CHEK2	672	11200	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Age at onset of bilateral_breast_cancer , the presence of hereditary BRCA1 , BRCA2 , CHEK2 gene mutations and positive family history of cancer .
21356067	0	BRCA1	14,19	CHEK2	28,33	BRCA1	CHEK2	672	11200	Gene	Gene	RAD50|compound|START_ENTITY RAD50|appos|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
11704836	0	BRCA1	19,24	CREB	2,6	BRCA1	CREB	672	1385	Gene	Gene	promoter|compound|START_ENTITY site|nmod|promoter site|compound|END_ENTITY	A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element .
19568323	0	BRCA1	18,23	CREB	10,14	BRCA1	CREB	672	1385	Gene	Gene	Activity|compound|START_ENTITY Role|nmod|Activity Role|nmod|END_ENTITY	A Role of CREB in BRCA1 Constitutive Promoter Activity and Aromatase Basal Expression .
16979166	0	BRCA1	20,25	Caveolin-1	0,10	BRCA1	Caveolin-1	672	857	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast_cancer cells .
25594072	0	BRCA1	57,62	Caveolin-1	27,37	BRCA1	Caveolin-1	672	857	Gene	Gene	Dysfunction|compound|START_ENTITY Down-Regulation|nmod|Dysfunction Down-Regulation|compound|END_ENTITY	A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian_Cancer Cells .
14701743	0	BRCA1	24,29	Chk2	0,4	BRCA1	Chk2	672	11200	Gene	Gene	break|compound|START_ENTITY phosphorylation|nmod|break phosphorylation|amod|END_ENTITY	Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair .
18804494	0	BRCA1	0,5	Chk2	22,26	BRCA1	Chk2	672	11200	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	BRCA1 is regulated by Chk2 in response to spindle damage .
25659039	0	BRCA1	15,20	Chk2	40,44	BRCA1	Chk2	672	11200	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection .
16462773	0	BRCA1	41,46	DNA_repair_protein	11,29	BRCA1	DNA repair protein	672	442459	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	BACH1 is a DNA_repair_protein supporting BRCA1 damage response .
12909625	0	BRCA1	26,31	E2F6	0,4	BRCA1	E2F6	672	1876	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 .
17096023	0	BRCA1	74,79	E2F6	0,4	BRCA1	E2F6	672	1876	Gene	Gene	modulation|nmod|START_ENTITY apoptosis|nmod|modulation regulates|dobj|apoptosis regulates|nsubj|END_ENTITY	E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1 .
19683826	0	BRCA1	38,43	ERCC1	31,36	BRCA1	ERCC1	672	2067	Gene	Gene	XRCC1|appos|START_ENTITY XRCC1|compound|END_ENTITY	The prognostic significance of ERCC1 , BRCA1 , XRCC1 , and betaIII-tubulin expression in patients with non-small_cell_lung_cancer treated by platinum - and taxane-based neoadjuvant chemotherapy and surgical resection .
21529986	0	BRCA1	9,14	ERCC1	16,21	BRCA1	ERCC1	672	2067	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Tubulin , BRCA1 , ERCC1 , Abraxas , RAP80 mRNA expression , p53/p21 immunohistochemistry and clinical outcome in patients with advanced non_small-cell_lung_cancer receiving first-line platinum-gemcitabine chemotherapy .
24058603	0	BRCA1	20,25	ERCC1	27,32	BRCA1	ERCC1	672	2067	Gene	Gene	TOPOI|compound|START_ENTITY TOPOI|appos|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
12354784	0	BRCA1	0,5	FANCA	57,62	BRCA1	FANCA	672	2175	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRCA1 interacts directly with the Fanconi_anemia protein FANCA .
12239151	0	BRCA1	73,78	FANCD2	60,66	BRCA1	FANCD2	672	2177	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	S-phase-specific interaction of the Fanconi_anemia protein , FANCD2 , with BRCA1 and RAD51 .
14712086	0	BRCA1	15,20	FANCL	0,5	BRCA1	FANCL	672	55120	Gene	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination .
14550570	0	BRCA1	0,5	FHL2	21,25	BRCA1	FHL2	672	2274	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRCA1 interacts with FHL2 and enhances FHL2 transactivation function .
27043660	0	BRCA1	0,5	FOXO3	27,32	BRCA1	FOXO3	672	2309	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast_cancer .
27043660	0	BRCA1	0,5	FOXO3	59,64	BRCA1	FOXO3	672	2309	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|restricting restricting|xcomp|silencing silencing|nsubj|gene gene|compound|END_ENTITY	BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast_cancer .
22328717	0	BRCA1	86,91	GABP_beta	100,109	BRCA1	GABP beta	672	2553	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
26442220	0	BRCA1	98,103	GABP_beta	112,121	BRCA1	GABP beta	672	2553	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Commentary : The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
11777930	0	BRCA1	0,5	GADD45	16,22	BRCA1	GADD45	672	1647	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs .
24629067	0	BRCA1	47,52	Glucocorticoid_receptor	0,23	BRCA1	Glucocorticoid receptor	672	2908	Gene	Gene	inactivation|compound|START_ENTITY mediated|nmod|inactivation mediated|nsubj|repression repression|amod|END_ENTITY	Glucocorticoid_receptor repression mediated by BRCA1 inactivation in ovarian_cancer .
18030615	0	BRCA1	47,52	HIF-1alpha	18,28	BRCA1	HIF-1alpha	672	3091	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|compound|END_ENTITY	High frequency of HIF-1alpha overexpression in BRCA1 related breast_cancer .
20389018	0	BRCA1	16,21	HOXA9	0,5	BRCA1	HOXA9	672	3205	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HOXA9 regulates BRCA1 expression to modulate human breast_tumor phenotype .
24342616	0	BRCA1	21,26	HUWE1	0,5	BRCA1	HUWE1	672	10075	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway .
24472556	0	BRCA1	21,26	HUWE1	0,5	BRCA1	HUWE1	672	10075	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway .
17374731	0	BRCA1	0,5	IFN-gamma	16,25	BRCA1	IFN-gamma	672	3458	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BRCA1 regulates IFN-gamma signaling through a mechanism involving the type I IFNs .
22739988	0	BRCA1	0,5	IGF-1	27,32	BRCA1	IGF-1	672	3479	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site .
21673012	0	BRCA1	24,29	KIAA0101	0,8	BRCA1	KIAA0101	672	9768	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	KIAA0101 interacts with BRCA1 and regulates centrosome number .
23354597	0	BRCA1	58,63	MS110	33,38	BRCA1	MS110	672	3207690(Tax:155537)	Gene	Gene	Validation|nmod|START_ENTITY Validation|nmod|END_ENTITY	Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast_and_ovarian_tumours .
15107825	0	BRCA1	0,5	NUFIP	22,27	BRCA1	NUFIP	672	26747	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II .
19509300	0	BRCA1	0,5	Nlp	41,44	BRCA1	Nlp	672	22981	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression .
23353771	0	BRCA1	78,83	Nrf2	0,4	BRCA1	Nrf2	672	4780	Gene	Gene	gene|compound|START_ENTITY activity|nmod|gene regulation|nmod|activity associated|nmod|regulation associated|nsubjpass|END_ENTITY	Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene .
23857982	0	BRCA1	0,5	Nrf2	21,25	BRCA1	Nrf2	12189(Tax:10090)	18024(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival .
19268590	0	BRCA1	12,17	PALB2	0,5	BRCA1	PALB2	672	79728	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	PALB2 links BRCA1 and BRCA2 in the DNA-damage response .
21356067	0	BRCA1	14,19	PALB2	35,40	BRCA1	PALB2	672	79728	Gene	Gene	RAD50|compound|START_ENTITY RAD50|appos|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
23901102	0	BRCA1	0,5	PCNA	37,41	BRCA1	PCNA	672	5111	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade .
24058603	0	BRCA1	20,25	PKM2	41,45	BRCA1	PKM2	672	5315	Gene	Gene	TOPOI|compound|START_ENTITY TOPOI|appos|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
17511879	0	BRCA1	28,33	PP1	19,22	BRCA1	PP1	672	5464	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of PP1 with BRCA1 and analysis of their expression in breast_tumors .
25992773	0	BRCA1	15,20	Pit-1	0,5	BRCA1	Pit-1	672	5449	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Pit-1 inhibits BRCA1 and sensitizes human breast_tumors to cisplatin and vitamin_D treatment .
26745677	0	BRCA1	28,33	Polo-like_kinase_1	0,18	BRCA1	Polo-like kinase 1	672	5347	Gene	Gene	phosphorylation|compound|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Polo-like_kinase_1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks .
26970274	0	BRCA1	67,72	Prolactin	0,9	BRCA1	Prolactin	672	5617	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Prolactin inhibits a major tumor-suppressive function of wild type BRCA1 .
12750242	0	BRCA1	90,95	RAD51	49,54	BRCA1	RAD51	672	5888	Gene	Gene	mutation|compound|START_ENTITY carriers|nmod|mutation associated|nmod|carriers associated|nmod|polymorphism polymorphism|compound|END_ENTITY	Breast_cancer risk reduction associated with the RAD51 polymorphism among carriers of the BRCA1 5382insC mutation in Poland .
16165098	0	BRCA1	25,30	RAD51	70,75	BRCA1	RAD51	672	5888	Gene	Gene	carboxyl-terminal|nmod|START_ENTITY required|nsubjpass|carboxyl-terminal required|nmod|assembly assembly|nmod|END_ENTITY	The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast_and_ovarian_cancer cells .
16357146	0	BRCA1	0,5	RAD51	16,21	BRCA1	RAD51	672	5888	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nummod|END_ENTITY	BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage : implications for sister chromatid cohesion , genome stability , and carcinogenesis .
16477874	0	BRCA1	9,14	RAD51	83,88	BRCA1	RAD51	672	5888	Gene	Gene	mutations|compound|START_ENTITY mutations|acl|untranslated untranslated|dobj|region region|nmod|gene gene|compound|END_ENTITY	Germline BRCA1 mutations and G/C polymorphism in the 5 ' - untranslated region of the RAD51 gene in Polish women with breast_cancer .
17301259	0	BRCA1	88,93	RAD51	4,9	BRCA1	RAD51	672	5888	Gene	Gene	carriers|compound|START_ENTITY risk|nmod|carriers modifies|dobj|risk modifies|nsubj|polymorphism polymorphism|compound|END_ENTITY	The RAD51 135_G > C polymorphism modifies breast_cancer and ovarian_cancer risk in Polish BRCA1 mutation carriers .
22865450	0	BRCA1	79,84	RAD51	27,32	BRCA1	RAD51	672	5888	Gene	Gene	absence|nmod|START_ENTITY breaks|nmod|absence regulates|nmod|breaks regulates|dobj|assembly assembly|nmod|END_ENTITY	RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1 .
17525341	0	BRCA1	14,19	RAP80	0,5	BRCA1	RAP80	672	51720	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites .
17621610	0	BRCA1	72,77	RAP80	51,56	BRCA1	RAP80	672	51720	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response .
18270812	0	BRCA1	18,23	RAP80	42,47	BRCA1	RAP80	672	51720	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|acl|interacting interacting|dobj|genes genes|nummod|END_ENTITY	Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast_cancer susceptibility .
21529986	0	BRCA1	9,14	RAP80	32,37	BRCA1	RAP80	672	51720	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Tubulin , BRCA1 , ERCC1 , Abraxas , RAP80 mRNA expression , p53/p21 immunohistochemistry and clinical outcome in patients with advanced non_small-cell_lung_cancer receiving first-line platinum-gemcitabine chemotherapy .
10843985	0	BRCA1	38,43	Rad51	83,88	BRCA1	Rad51	12189(Tax:10090)	19361(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|assembly assembly|nmod|END_ENTITY	The breast_cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin .
20979543	0	BRCA1	0,5	Rad51	81,86	BRCA1	Rad51	672	5888	Gene	Gene	heterozygosity|compound|START_ENTITY reduces|nsubj|heterozygosity reduces|iobj|END_ENTITY	BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity .
21103343	0	BRCA1	55,60	Rad51	71,76	BRCA1	Rad51	672	5888	Gene	Gene	proteolysis|nmod|START_ENTITY regulates|nsubj|proteolysis regulates|dobj|recruitment recruitment|amod|END_ENTITY	PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells .
21708019	0	BRCA1	53,58	Rad51	15,20	BRCA1	Rad51	672	5888	Gene	Gene	carriers|nummod|START_ENTITY repair|nmod|carriers repair|nsubj|Association Association|nmod|polymorphism polymorphism|amod|END_ENTITY	Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast_cancer risk .
9008167	0	BRCA1	15,20	Rad51	26,31	BRCA1	Rad51	672	5888	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of BRCA1 with Rad51 in mitotic and meiotic cells .
26513018	0	BRCA1	63,68	Rak	12,15	BRCA1	Rak	672	2444	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Rak in the regulation of stability and function of BRCA1 .
19768112	0	BRCA1	0,5	Smad3	21,26	BRCA1	Smad3	672	4088	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses .
26022109	0	BRCA1	0,5	TGF-b1	46,52	BRCA1	TGF-b1	672	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
26022109	0	BRCA1	0,5	TGF-b1	46,52	BRCA1	TGF-b1	672	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
11027532	0	BRCA1	19,24	TGF-beta1	0,9	BRCA1	TGF-beta1	672	7040	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits BRCA1 expression through a pathway that requires pRb .
23447579	0	BRCA1	20,25	TNRC9	0,5	BRCA1	TNRC9	12189(Tax:10090)	244579(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	TNRC9 downregulates BRCA1 expression and promotes breast_cancer_aggressiveness .
10337991	0	BRCA1	41,46	TP53	23,27	BRCA1	TP53	672	7157	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian_tumours .
10432928	0	BRCA1	117,122	TP53	10,14	BRCA1	TP53	672	7157	Gene	Gene	Li-Fraumeni_syndrome|nmod|START_ENTITY features|nmod|Li-Fraumeni_syndrome exhibiting|dobj|features mutations|acl|exhibiting mutations|compound|END_ENTITY	Germ-line TP53 mutations in Finnish cancer families exhibiting features of the Li-Fraumeni_syndrome and negative for BRCA1 and BRCA2 .
11358831	0	BRCA1	48,53	TP53	0,4	BRCA1	TP53	672	7157	Gene	Gene	mutations|nummod|START_ENTITY associated|nmod|mutations breast_cancer|acl|associated mutations|nmod|breast_cancer mutations|nummod|END_ENTITY	TP53 mutations in breast_cancer associated with BRCA1 or BRCA2 germ-line mutations : distinctive spectrum and structural distribution .
16229746	0	BRCA1	86,91	TP53	0,4	BRCA1	TP53	672	7157	Gene	Gene	mutations|compound|START_ENTITY cases|nmod|mutations ovarian_carcinomas|nmod|cases mutations|nmod|ovarian_carcinomas mutations|nummod|END_ENTITY	TP53 mutations in ovarian_carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations ; relation to age at diagnosis and survival .
17541742	0	BRCA1	27,32	TP53	9,13	BRCA1	TP53	672	7157	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Germline TP53 mutations in BRCA1 and BRCA2 mutation-negative French Canadian breast_cancer families .
18402691	0	BRCA1	65,70	TP53	22,26	BRCA1	TP53	672	7157	Gene	Gene	carriers|compound|START_ENTITY analysis|nmod|carriers analysis|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Haplotype analysis of TP53 polymorphisms , Arg72Pro and Ins16 , in BRCA1 and BRCA2 mutation carriers of French Canadian descent .
19707196	0	BRCA1	94,99	TP53	4,8	BRCA1	TP53	672	7157	Gene	Gene	carriers|compound|START_ENTITY risk|nmod|carriers associated|nmod|risk associated|nsubjpass|Arg72Pro Arg72Pro|nummod|END_ENTITY	The TP53 Arg72Pro and MDM2 309G > T polymorphisms are not associated with breast_cancer risk in BRCA1 and BRCA2 mutation carriers .
22507745	0	BRCA1	24,29	TP53	105,109	BRCA1	TP53	672	7157	Gene	Gene	frequency|nmod|START_ENTITY germline|nsubj|frequency germline|ccomp|suggests suggests|ccomp|offered offered|nsubjpass|screening screening|compound|END_ENTITY	Comparable frequency of BRCA1 , BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast_cancer patients .
23664366	0	BRCA1	133,138	TP53	159,163	BRCA1	TP53	12189(Tax:10090)	22059(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY initiated|nmod|loss initiated|nmod|haploinsufficiency haploinsufficiency|compound|END_ENTITY	The PPARy agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency .
26140185	0	BRCA1	16,21	TP53	0,4	BRCA1	TP53	672	7157	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro .
26140185	0	BRCA1	16,21	TP53	0,4	BRCA1	TP53	672	7157	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro .
15609132	0	BRCA1	69,74	Vascular_endothelial_growth_factor	0,34	BRCA1	Vascular endothelial growth factor	672	7422	Gene	Gene	gene|compound|START_ENTITY levels|nmod|gene END_ENTITY|dep|levels	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels and mutation of the BRCA1 gene in breast_cancer patients .
19289372	0	BRCA1	105,110	XPG	0,3	BRCA1	XPG	672	2073	Gene	Gene	expression|compound|START_ENTITY modulate|nmod|expression modulate|nsubj|levels levels|compound|END_ENTITY	XPG mRNA expression levels modulate prognosis in resected non-small-cell lung_cancer in conjunction with BRCA1 and ERCC1 expression .
26833090	0	BRCA1	33,38	XPG	24,27	BRCA1	XPG	672	2073	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability .
21666725	0	BRCA1	32,37	Yin_Yang_1	0,10	BRCA1	Yin Yang 1	672	7528	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Yin_Yang_1 positively regulates BRCA1 and inhibits mammary cancer formation .
23764426	0	BRCA1	93,98	ZNF423	72,78	BRCA1	ZNF423	672	23090	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nummod|END_ENTITY	Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression : individualized breast_cancer prevention .
20103632	0	BRCA1	0,5	amphiregulin	16,28	BRCA1	amphiregulin	672	374	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	BRCA1 represses amphiregulin gene expression .
24321324	0	BRCA1	96,101	angiotensin_II_type_1_receptor	14,44	BRCA1	angiotensin II type 1 receptor	672	185	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of angiotensin_II_type_1_receptor expression in ovarian_cancer : a potential role for BRCA1 .
15563594	0	BRCA1	51,56	breast-cancer-associated_gene_1	18,49	BRCA1	breast-cancer-associated gene 1	12189(Tax:10090)	12189(Tax:10090)	Gene	Gene	requirement|appos|START_ENTITY requirement|nmod|END_ENTITY	A requirement for breast-cancer-associated_gene_1 -LRB- BRCA1 -RRB- in the spindle checkpoint .
23339184	0	BRCA1	33,38	c-Jun	58,63	BRCA1	c-Jun	672	3725	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in premalignant human ovarian surface epithelial cells .
21668996	0	BRCA1	16,21	c-Myc	0,5	BRCA1	c-Myc	672	4609	Gene	Gene	expression|nummod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	c-Myc activates BRCA1 gene expression through distal promoter elements in breast_cancer cells .
9788437	0	BRCA1	0,5	c-Myc	12,17	BRCA1	c-Myc	672	4609	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells .
18343216	0	BRCA1	0,5	caveolin-1	16,26	BRCA1	caveolin-1	672	857	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	BRCA1 regulates caveolin-1 expression and inhibits cell invasiveness .
18682421	0	BRCA1	62,67	epidermal_growth_factor_receptor	14,46	BRCA1	epidermal growth factor receptor	672	1956	Gene	Gene	status|nummod|START_ENTITY relation|nmod|status Expression|nmod|relation Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor_receptor in relation to BRCA1 status , basal-like markers and prognosis in breast_cancer .
21396117	0	BRCA1	8,13	epidermal_growth_factor_receptor	38,70	BRCA1	epidermal growth factor receptor	12189(Tax:10090)	13649(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY leads|nsubj|Loss leads|nmod|increase increase|nmod|expression expression|compound|END_ENTITY	Loss of BRCA1 leads to an increase in epidermal_growth_factor_receptor expression in mammary epithelial cells , and epidermal_growth_factor_receptor inhibition prevents estrogen_receptor-negative cancers in BRCA1-mutant mice .
24321281	0	BRCA1	10,15	epidermal_growth_factor_receptor	19,51	BRCA1	epidermal growth factor receptor	672	1956	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of BRCA1 on epidermal_growth_factor_receptor in ovarian_cancer .
24452282	0	BRCA1	81,86	epidermal_growth_factor_receptor	20,52	BRCA1	epidermal growth factor receptor	672	1956	Gene	Gene	expression|compound|START_ENTITY number|appos|expression copy|dobj|number copy|nsubj|Association Association|nmod|gene gene|compound|END_ENTITY	Association between epidermal_growth_factor_receptor gene copy number and ERCC1 , BRCA1 protein expression in Chinese patients with non-small_cell_lung_cancer .
25417703	0	BRCA1	0,5	epidermal_growth_factor_receptor	20,52	BRCA1	epidermal growth factor receptor	672	1956	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	BRCA1 regulation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in human breast_cancer cells involves microRNA-146a and is critical for its tumor suppressor function .
22328717	0	BRCA1	86,91	glucocorticoid_receptor	15,38	BRCA1	glucocorticoid receptor	672	2908	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
26442220	0	BRCA1	98,103	glucocorticoid_receptor	27,50	BRCA1	glucocorticoid receptor	672	2908	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Commentary : The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
21099359	0	BRCA1	0,5	hnRNPA2B1	34,43	BRCA1	hnRNPA2B1	672	3181	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	BRCA1 modulates the expression of hnRNPA2B1 and KHSRP .
24765210	0	BRCA1	0,5	insulin-like_growth_factor_1_receptor	16,53	BRCA1	insulin-like growth factor 1 receptor	672	3480	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	BRCA1 regulates insulin-like_growth_factor_1_receptor levels in ovarian_cancer .
24475217	0	BRCA1	18,23	miR-342	0,7	BRCA1	miR-342	672	442909	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-342 regulates BRCA1 expression through modulation of ID4 in breast_cancer .
26933805	0	BRCA1	95,100	miR-498	73,80	BRCA1	miR-498	672	574460	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|advcl|regulating	MicroRNA deregulation in triple negative breast_cancer reveals a role of miR-498 in regulating BRCA1 expression .
25228385	0	BRCA1	31,36	miR-638	0,7	BRCA1	miR-638	672	693223	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast_cancer .
21946536	0	BRCA1	17,22	microRNA-155	57,69	BRCA1	microRNA-155	672	406947	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155 .
20081198	0	BRCA1	27,32	p140	83,87	BRCA1	p140	672	80725	Gene	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Structure of the DNA-bound BRCA1 C-terminal region from human replication factor C p140 and model of the protein-DNA complex .
21245169	0	BRCA1	42,47	p21	55,58	BRCA1	p21	672	1026	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation .
12082635	0	BRCA1	0,5	p27	59,62	BRCA1	p27	672	3429	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	BRCA1 transactivates the cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- .
12548593	0	BRCA1	19,24	p53	57,60	BRCA1	p53	672	7157	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast_carcinoma : 10-year follow up data .
16109739	0	BRCA1	38,43	progesterone_receptor	54,75	BRCA1	progesterone receptor	672	5241	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The breast_cancer susceptibility gene BRCA1 regulates progesterone_receptor signaling in mammary epithelial cells .
16741564	0	BRCA1	49,54	progesterone_receptor	14,35	BRCA1	progesterone receptor	672	5241	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of progesterone_receptor signaling by BRCA1 in mammary cancer .
12646176	0	BRCA1	72,77	telomerase_reverse_transcriptase	20,52	BRCA1	telomerase reverse transcriptase	672	7015	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of human telomerase_reverse_transcriptase gene expression by BRCA1 in human ovarian_cancer cells .
25657994	0	BRCA1-Associated_ATM_Activator-1	22,54	BRAT1	56,61	BRCA1-Associated ATM Activator-1	BRAT1	231841(Tax:10090)	231841(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Potential Role of BRCA1-Associated_ATM_Activator-1 -LRB- BRAT1 -RRB- in Regulation of mTOR .
25657994	0	BRCA1-Associated_ATM_Activator-1	22,54	mTOR	80,84	BRCA1-Associated ATM Activator-1	mTOR	231841(Tax:10090)	21977(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Regulation Regulation|nmod|END_ENTITY	The Potential Role of BRCA1-Associated_ATM_Activator-1 -LRB- BRAT1 -RRB- in Regulation of mTOR .
23096105	0	BRCA1/2	81,88	BRCA2	47,52	BRCA1/2	BRCA2	672;675	675	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel in-frame deletion in BRCA2 and analysis of variants of BRCA1/2 in Italian patients affected with hereditary_breast_and_ovarian_cancer .
11118465	0	BRCA1/2	9,16	Kip1	35,39	BRCA1/2	Kip1	672;675	1027	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Germline BRCA1/2 mutations and p27 -LRB- Kip1 -RRB- protein levels independently predict outcome after breast_cancer .
26246155	0	BRCA1_associated_protein-1	35,61	BAP1	63,67	BRCA1 associated protein-1	BAP1	8314	8314	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Frequent genomic rearrangements of BRCA1_associated_protein-1 -LRB- BAP1 -RRB- gene in Japanese malignant mesothelioma-characterization of deletions at exon level .
19653894	0	BRCA2	24,29	BCCIP	15,20	BRCA2	BCCIP	675	56647	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of BCCIP , a BRCA2 interacting protein , in astrocytomas .
10505028	0	BRCA2	82,87	BRCA1	21,26	BRCA2	BRCA1	675	672	Gene	Gene	3414del4|compound|START_ENTITY analysis|dep|3414del4 analysis|nmod|END_ENTITY	Mutation analysis of BRCA1 and BRCA2 in Turkish cancer families : a novel mutation BRCA2 3414del4 found in male_breast_cancer .
10790213	0	BRCA2	47,52	BRCA1	8,13	BRCA2	BRCA1	675	672	Gene	Gene	mutations|nummod|START_ENTITY germline|dobj|mutations germline|nsubj|mutations mutations|compound|END_ENTITY	Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast_and / or_ovarian_cancer families from North-Eastern Poland .
10818594	0	BRCA2	36,41	BRCA1	29,34	BRCA2	BRCA1	675	672	Gene	Gene	K-ras|nummod|START_ENTITY K-ras|nummod|END_ENTITY	Mutation detection in K-ras , BRCA1 , BRCA2 , and p53 using PCR/LDR and a universal DNA microarray .
11391658	0	BRCA2	84,89	BRCA1	61,66	BRCA2	BRCA1	675	672	Gene	Gene	gene|compound|START_ENTITY 2594delC|nmod|gene 2594delC|nmod|END_ENTITY	Caucasian family with two independent mutations : 2594delC in BRCA1 and 5392delAG in BRCA2 gene .
12125210	0	BRCA2	43,48	BRCA1	22,27	BRCA2	BRCA1	675	672	Gene	Gene	5382insC|appos|START_ENTITY 5382insC|appos|END_ENTITY	Analysis of 5382insC -LRB- BRCA1 -RRB- and 6174delT -LRB- BRCA2 -RRB- mutations in 382 healthy Chilean women with a family history of breast_cancer .
12142080	0	BRCA2	18,23	BRCA1	10,15	BRCA2	BRCA1	675	672	Gene	Gene	mutations|nummod|START_ENTITY _|dobj|mutations _|nsubj|END_ENTITY	Germ line BRCA1 _ BRCA2 mutations in Greek breast/ovarian _ cancer families : 5382insC is the most frequent mutation observed .
12673274	0	BRCA2	80,85	BRCA1	58,63	BRCA2	BRCA1	675	672	Gene	Gene	genes|nummod|START_ENTITY 3358T/A|nmod|genes 3358T/A|nmod|END_ENTITY	Italian family with two independent mutations : 3358T/A in BRCA1 and 8756delA in BRCA2 genes .
17289874	0	BRCA2	74,79	BRCA1	67,72	BRCA2	BRCA1	675	672	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Epigenetic inactivation of the chromosomal stability control genes BRCA1 , BRCA2 , and XRCC5 in non-small cell lung_cancer .
17307353	0	BRCA2	89,94	BRCA1	97,102	BRCA2	BRCA1	675	672	Gene	Gene	hereditary_breast_cancer|nmod|START_ENTITY factors|nmod|hereditary_breast_cancer characteristics|appos|factors END_ENTITY|nsubj|characteristics	Tumour characteristics , survival and prognostic factors of hereditary_breast_cancer from BRCA2 - , BRCA1 - and non-BRCA1 / 2 families as compared to sporadic_breast_cancer cases .
17341484	0	BRCA2	51,56	BRCA1	44,49	BRCA2	BRCA1	675	672	Gene	Gene	predicts|nsubj|START_ENTITY predicts|nmod|variants variants|nmod|END_ENTITY	Counting potentially functional variants in BRCA1 , BRCA2 and ATM predicts breast_cancer susceptibility .
17428325	0	BRCA2	35,40	BRCA1	28,33	BRCA2	BRCA1	675	672	Gene	Gene	ATM|nummod|START_ENTITY ATM|nummod|END_ENTITY	Common variants in the ATM , BRCA1 , BRCA2 , CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast_cancer risk .
17624602	0	BRCA2	7,12	BRCA1	0,5	BRCA2	BRCA1	675	672	Gene	Gene	germline|nsubj|START_ENTITY germline|advmod|END_ENTITY	BRCA1 , BRCA2 , TP53 , and CDKN2A germline mutations in patients with breast_cancer and cutaneous_melanoma .
18429825	0	BRCA2	51,56	BRCA1	44,49	BRCA2	BRCA1	675	672	Gene	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	Dinucleotide repeat polymorphisms of RAD51 , BRCA1 , BRCA2 gene regions in breast_cancer .
18559571	0	BRCA2	37,42	BRCA1	57,62	BRCA2	BRCA1	675	672	Gene	Gene	START_ENTITY|nmod|mutations mutations|nummod|END_ENTITY	Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian_cancer .
19189213	0	BRCA2	49,54	BRCA1	90,95	BRCA2	BRCA1	675	672	Gene	Gene	breast_tumors|nummod|START_ENTITY breast_tumors|dep|not not|nmod|END_ENTITY	Frequent somatic mutations of GATA3 in non-BRCA1 / BRCA2 familial breast_tumors , but not in BRCA1 - , BRCA2 - or sporadic breast_tumors .
19189213	0	BRCA2	98,103	BRCA1	90,95	BRCA2	BRCA1	675	672	Gene	Gene	breast_tumors|amod|START_ENTITY breast_tumors|dep|not not|nmod|END_ENTITY	Frequent somatic mutations of GATA3 in non-BRCA1 / BRCA2 familial breast_tumors , but not in BRCA1 - , BRCA2 - or sporadic breast_tumors .
19372713	0	BRCA2	75,80	BRCA1	68,73	BRCA2	BRCA1	675	672	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Age at onset of bilateral_breast_cancer , the presence of hereditary BRCA1 , BRCA2 , CHEK2 gene mutations and positive family history of cancer .
19649760	0	BRCA2	52,57	BRCA1	44,49	BRCA2	BRCA1	675	672	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Clinical and pathologic differences between BRCA1 - , BRCA2 - , and non-BRCA-associated breast_cancers in a multiracial developing country .
20676756	0	BRCA2	108,113	BRCA1	81,86	BRCA2	BRCA1	675	672	Gene	Gene	families|compound|START_ENTITY families|compound|BRCA2 BRCA2|compound|END_ENTITY	Prevalence of the variant allele rs61764370 T > G in the 3 ` UTR of KRAS among Dutch BRCA1 , BRCA2 and non-BRCA1 / BRCA2 breast_cancer families .
21356067	0	BRCA2	21,26	BRCA1	14,19	BRCA2	BRCA1	675	672	Gene	Gene	RAD50|appos|START_ENTITY RAD50|compound|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
22113258	0	BRCA2	47,52	BRCA1	41,46	BRCA2	BRCA1	675	672	Gene	Gene	families|compound|START_ENTITY families|compound|END_ENTITY	Phenocopy breast_cancer rates in Israeli BRCA1 BRCA2 mutation carrier families : is the risk increased in non-carriers ?
22348646	0	BRCA2	116,121	BRCA1	103,108	BRCA2	BRCA1	675	672	Gene	Gene	carriers|compound|START_ENTITY carriers|compound|END_ENTITY	Common variants at 12p11 , 12q24 , 9p21 , 9q31 .2 and in ZNF365 are associated with breast_cancer risk for BRCA1 and/or BRCA2 mutation carriers .
22964643	0	BRCA2	95,100	BRCA1	64,69	BRCA2	BRCA1	675	672	Gene	Gene	lethal|xcomp|START_ENTITY lethal|nmod|deficiencies deficiencies|nmod|END_ENTITY	RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination .
25356972	0	BRCA2	7,12	BRCA1	0,5	BRCA2	BRCA1	675	672	Gene	Gene	PALB2|appos|START_ENTITY PALB2|compound|END_ENTITY	BRCA1 , BRCA2 , PALB2 , and CDKN2A mutations in familial pancreatic_cancer : a PACGENE study .
25673166	0	BRCA2	44,49	BRCA1	36,41	BRCA2	BRCA1	675	672	Gene	Gene	carriers|compound|START_ENTITY carriers|compound|END_ENTITY	Breast_cancer detection among Irish BRCA1 _ BRCA2 mutation carriers : a population-based study .
27068824	0	BRCA2	22,27	BRCA1	15,20	BRCA2	BRCA1	675	672	Gene	Gene	RAD51|dep|START_ENTITY RAD51|compound|END_ENTITY	Association of BRCA1 , BRCA2 , RAD51 , and HER2 gene polymorphisms with the breast_cancer risk in the Bangladeshi population .
9042909	0	BRCA2	69,74	BRCA1	47,52	BRCA2	BRCA1	675	672	Gene	Gene	185delAG|nmod|START_ENTITY 185delAG|nmod|END_ENTITY	The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60 % of ovarian_cancer and 30 % of early-onset breast_cancer patients among Ashkenazi women .
9150150	0	BRCA2	0,5	BRCA1	212,217	BRCA2	BRCA1	675	672	Gene	Gene	START_ENTITY|dep|mutations mutations|nmod|families families|acl:relcl|attributable attributable|nmod|END_ENTITY	BRCA2 in American families with four or more cases of breast or ovarian_cancer : recurrent and novel mutations , variable expression , penetrance , and the possibility of families whose cancer is not attributable to BRCA1 or BRCA2 .
9743298	0	BRCA2	76,81	BRCA1	36,41	BRCA2	BRCA1	675	672	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate_cancer .
23096105	0	BRCA2	47,52	BRCA1/2	81,88	BRCA2	BRCA1/2	675	672;675	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel in-frame deletion in BRCA2 and analysis of variants of BRCA1/2 in Italian patients affected with hereditary_breast_and_ovarian_cancer .
10797254	0	BRCA2	0,5	BRCA2	86,91	BRCA2	BRCA2	675	675	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	BRCA2 protein expression in sporadic_breast_carcinoma with or without allelic loss of BRCA2 .
10797254	0	BRCA2	86,91	BRCA2	0,5	BRCA2	BRCA2	675	675	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	BRCA2 protein expression in sporadic_breast_carcinoma with or without allelic loss of BRCA2 .
20676756	0	BRCA2	108,113	BRCA2	88,93	BRCA2	BRCA2	675	675	Gene	Gene	families|compound|START_ENTITY families|compound|END_ENTITY	Prevalence of the variant allele rs61764370 T > G in the 3 ` UTR of KRAS among Dutch BRCA1 , BRCA2 and non-BRCA1 / BRCA2 breast_cancer families .
20676756	0	BRCA2	88,93	BRCA2	108,113	BRCA2	BRCA2	675	675	Gene	Gene	families|compound|START_ENTITY families|compound|END_ENTITY	Prevalence of the variant allele rs61764370 T > G in the 3 ` UTR of KRAS among Dutch BRCA1 , BRCA2 and non-BRCA1 / BRCA2 breast_cancer families .
9724085	0	BRCA2	34,39	BRCA2	72,77	BRCA2	BRCA2	675	675	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate_cancer .
9724085	0	BRCA2	72,77	BRCA2	34,39	BRCA2	BRCA2	675	675	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Immunohistochemical expression of BRCA2 protein and allelic loss at the BRCA2 locus in prostate_cancer .
18723021	0	BRCA2	16,21	CDC45	61,66	BRCA2	CDC45	675	8318	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	A kinetoplastid BRCA2 interacts with DNA replication protein CDC45 .
26387543	0	BRCA2	79,84	Cyclin_D1	0,9	BRCA2	Cyclin D1	675	595	Gene	Gene	phosphorylation|compound|START_ENTITY restricting|dobj|phosphorylation promotes|advcl|restricting promotes|nsubj|END_ENTITY	Cyclin_D1 promotes BRCA2-Rad51 interaction by restricting cyclin_A / B-dependent BRCA2 phosphorylation .
15611632	1	BRCA2	101,106	FAAP95	85,91	BRCA2	FAAP95	675	2187	Gene	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	FAAP95 replaces BRCA2 as the true FANCB protein .
15611632	1	BRCA2	101,106	FANCB	119,124	BRCA2	FANCB	675	2187	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	FAAP95 replaces BRCA2 as the true FANCB protein .
15115758	0	BRCA2	34,39	FANCD2	22,28	BRCA2	FANCD2	675	2177	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways .
15671039	0	BRCA2	76,81	FANCD2	41,47	BRCA2	FANCD2	675	2177	Gene	Gene	recombination|amod|START_ENTITY functions|nmod|recombination functions|nsubj|D2 D2|appos|END_ENTITY	Fanconi_anemia complementation group D2 -LRB- FANCD2 -RRB- functions independently of BRCA2 - and RAD51-associated homologous recombination in response to DNA damage .
26338419	0	BRCA2	24,29	MERIT40	0,7	BRCA2	MERIT40	12190(Tax:10090)	68251(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links .
19609323	0	BRCA2	36,41	PALB2	45,50	BRCA2	PALB2	675	79728	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recruitment of BRCA2 by PALB2 .
24473064	0	BRCA2	40,45	PCAT-1	0,6	BRCA2	PCAT-1	675	100750225	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PCAT-1 , a long noncoding RNA , regulates BRCA2 and controls homologous recombination in cancer .
11239456	0	BRCA2	8,13	RAD51	32,37	BRCA2	RAD51	675	5888	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|recombination recombination|compound|END_ENTITY	Role of BRCA2 in control of the RAD51 recombination and DNA_repair_protein .
11248061	0	BRCA2	75,80	RAD51	40,45	BRCA2	RAD51	675	5888	Gene	Gene	risk|nmod|START_ENTITY modifies|dobj|risk modifies|nsubj|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers .
12941707	0	BRCA2	95,100	RAD51	65,70	BRCA2	RAD51	675	5888	Gene	Gene	assembly|nmod|START_ENTITY assembly|compound|END_ENTITY	Full-length archaeal Rad51 structure and mutants : mechanisms for RAD51 assembly and control by BRCA2 .
15138485	0	BRCA2	82,87	RAD51	40,45	BRCA2	RAD51	675	5888	Gene	Gene	carriers|nummod|START_ENTITY modifies|nmod|carriers modifies|nsubj|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	A single-nucleotide polymorphism in the RAD51 gene modifies breast_cancer risk in BRCA2 carriers , but not in BRCA1 carriers or noncarriers .
15703751	0	BRCA2	4,9	RAD51	35,40	BRCA2	RAD51	675	5888	Gene	Gene	Brh2|compound|START_ENTITY nucleates|nsubj|Brh2 nucleates|dobj|formation formation|compound|END_ENTITY	The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction .
17515904	0	BRCA2	75,80	RAD51	17,22	BRCA2	RAD51	675	5888	Gene	Gene	region|nmod|START_ENTITY filaments|nmod|region filaments|nsubj|Stabilization Stabilization|nmod|nucleoprotein nucleoprotein|compound|END_ENTITY	Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 .
17999359	0	BRCA2	49,54	RAD51	0,5	BRCA2	RAD51	675	5888	Gene	Gene	carriers|compound|START_ENTITY risk|nmod|carriers 135G|dep|risk 135G|compound|END_ENTITY	RAD51 135G -- > C modifies breast_cancer risk among BRCA2 mutation carriers : results from a combined analysis of 19 studies .
18429825	0	BRCA2	51,56	RAD51	37,42	BRCA2	RAD51	675	5888	Gene	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|nmod|BRCA1 BRCA1|compound|END_ENTITY	Dinucleotide repeat polymorphisms of RAD51 , BRCA1 , BRCA2 gene regions in breast_cancer .
19303847	0	BRCA2	19,24	RAD51	65,70	BRCA2	RAD51	675	5888	Gene	Gene	repeats|nmod|START_ENTITY modulate|nsubj|repeats modulate|dobj|selectivity selectivity|nmod|END_ENTITY	The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51 .
19628690	0	BRCA2	25,30	RAD51	55,60	BRCA2	RAD51	675	5888	Gene	Gene	repeats|nmod|START_ENTITY regulate|nsubj|repeats regulate|dobj|binding binding|compound|END_ENTITY	The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single - versus double-stranded DNA to stimulate strand exchange .
19875419	0	BRCA2	34,39	RAD51	96,101	BRCA2	RAD51	675	5888	Gene	Gene	interactions|compound|START_ENTITY repeats|nmod|interactions repeats|nmod|recombinase recombinase|compound|END_ENTITY	Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase .
20684611	0	BRCA2	78,83	RAD51	37,42	BRCA2	RAD51	675	5888	Gene	Gene	protein|compound|START_ENTITY motifs|nmod|protein based|nmod|motifs recombinase|acl|based recombinase|compound|END_ENTITY	Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein : modeling and experimental validation of a chimera peptide .
20729858	0	BRCA2	35,40	RAD51	76,81	BRCA2	RAD51	675	5888	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|specific specific|nmod|END_ENTITY	The breast_cancer_tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA .
20729859	0	BRCA2	6,11	RAD51	29,34	BRCA2	RAD51	675	5888	Gene	Gene	protein|compound|START_ENTITY promotes|nsubj|protein promotes|dobj|formation formation|compound|END_ENTITY	Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA .
21076401	0	BRCA2	0,5	RAD51	16,21	BRCA2	RAD51	675	5888	Gene	Gene	acts|nsubj|START_ENTITY acts|advcl|facilitate facilitate|nsubj|loader loader|compound|END_ENTITY	BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping .
21576230	0	BRCA2	14,19	RAD51	35,40	BRCA2	RAD51	675	5888	Gene	Gene	domain|compound|START_ENTITY domain|nmod|filaments filaments|nummod|END_ENTITY	Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques .
21670257	0	BRCA2	30,35	RAD51	44,49	BRCA2	RAD51	675	5888	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms .
22077663	0	BRCA2	0,5	RAD51	23,28	BRCA2	RAD51	675	832208(Tax:3702)	Gene	Gene	mediator|nsubj|START_ENTITY mediator|nmod|recombination recombination|amod|END_ENTITY	BRCA2 is a mediator of RAD51 - and DMC1-facilitated homologous recombination in Arabidopsis_thaliana .
23384538	0	BRCA2	0,5	RAD51	26,31	BRCA2	RAD51	675	5888	Gene	Gene	epistatic|nsubj|START_ENTITY epistatic|nmod|paralogs paralogs|nummod|END_ENTITY	BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage .
25488918	0	BRCA2	0,5	RAD51	43,48	BRCA2	RAD51	675	5888	Gene	Gene	diffuses|nsubj|START_ENTITY diffuses|nmod|END_ENTITY	BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells .
25778924	0	BRCA2	0,5	RAD51	43,48	BRCA2	RAD51	675	5888	Gene	Gene	diffuses|nsubj|START_ENTITY diffuses|nmod|END_ENTITY	BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells .
25876666	0	BRCA2	24,29	RAD51	69,74	BRCA2	RAD51	474180(Tax:9615)	403568(Tax:9615)	Gene	Gene	BRC|compound|START_ENTITY Polymorphisms|nmod|BRC repeats|nsubj|Polymorphisms repeats|xcomp|affecting affecting|nmod|END_ENTITY	Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51 .
25876666	0	BRCA2	24,29	RAD51	69,74	BRCA2	RAD51	474180(Tax:9615)	403568(Tax:9615)	Gene	Gene	BRC|compound|START_ENTITY Polymorphisms|nmod|BRC repeats|nsubj|Polymorphisms repeats|xcomp|affecting affecting|nmod|END_ENTITY	Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51 .
26992456	0	BRCA2	81,86	RAD51	75,80	RAD51	BRCA2	5888	675	Gene	Gene	Interaction|compound|START_ENTITY Relationship|dep|Interaction Relationship|dep|END_ENTITY	Structure Activity Relationship of the Peptide Binding Motif Mediating the RAD51 : BRCA2 Protein-Protein Interaction .
27084934	0	BRCA2	20,25	RAD51	41,46	BRCA2	RAD51	675	5888	Gene	Gene	BRC|compound|START_ENTITY Distinct|nmod|BRC repeats|nsubj|Distinct repeats|nmod|sensitivity sensitivity|compound|END_ENTITY	Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity .
9192668	0	BRCA2	23,28	RAD51	75,80	BRCA2	RAD51	12190(Tax:10090)	19361(Tax:10090)	Gene	Gene	START_ENTITY|dep|proteins proteins|acl:relcl|interact interact|nmod|protein protein|compound|END_ENTITY	RAB22 and RAB163/mouse BRCA2 : proteins that specifically interact with the RAD51 protein .
9523196	0	BRCA2	27,32	RAD51	69,74	BRCA2	RAD51	675	5888	Gene	Gene	sites|nmod|START_ENTITY sites|acl|interacting interacting|nmod|END_ENTITY	Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51 .
9560268	0	BRCA2	19,24	RAD51	42,47	BRCA2	RAD51	675	5888	Gene	Gene	repeats|nmod|START_ENTITY critical|nsubj|repeats critical|nmod|binding binding|compound|END_ENTITY	The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl_methanesulfonate treatment .
10446958	0	BRCA2	0,5	Rad51	61,66	BRCA2	Rad51	675	5888	Gene	Gene	required|nsubjpass|START_ENTITY required|advcl|ionizing ionizing|dobj|assembly assembly|nmod|complex complex|amod|END_ENTITY	BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo .
12504001	0	BRCA2	0,5	Rad51	12,17	BRCA2	Rad51	675	5888	Gene	Gene	keeps|nsubj|START_ENTITY keeps|dobj|END_ENTITY	BRCA2 keeps Rad51 in line .
12941707	0	BRCA2	95,100	Rad51	21,26	BRCA2	Rad51	675	5888	Gene	Gene	assembly|nmod|START_ENTITY mechanisms|nmod|assembly structure|dep|mechanisms structure|amod|END_ENTITY	Full-length archaeal Rad51 structure and mutants : mechanisms for RAD51 assembly and control by BRCA2 .
14580352	0	BRCA2	78,83	Rad51	19,24	BRCA2	Rad51	675	5888	Gene	Gene	recombinase|nmod|START_ENTITY recombinase|nsubj|control control|nmod|END_ENTITY	Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2 .
17767921	0	BRCA2	38,43	Rad51	18,23	BRCA2	Rad51	675	177914(Tax:6239)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Identification of Rad51 regulation by BRCA2 using Caenorhabditis_elegans BRCA2 and bimolecular fluorescence complementation analysis .
17767921	0	BRCA2	73,78	Rad51	18,23	BRCA2	Rad51	675	177914(Tax:6239)	Gene	Gene	using|dobj|START_ENTITY BRCA2|acl|using regulation|nmod|BRCA2 regulation|amod|END_ENTITY	Identification of Rad51 regulation by BRCA2 using Caenorhabditis_elegans BRCA2 and bimolecular fluorescence complementation analysis .
18429819	0	BRCA2	109,114	Rad51	42,47	BRCA2	Rad51	675	5888	Gene	Gene	protein|compound|START_ENTITY BRC-motif|nmod|protein derived|nmod|BRC-motif derived|nsubj|Inhibition Inhibition|nmod|formation formation|nmod|protein protein|amod|END_ENTITY	Inhibition of filament formation of human Rad51 protein by a small peptide derived from the BRC-motif of the BRCA2 protein .
19747923	0	BRCA2	46,51	Rad51	95,100	BRCA2	Rad51	675	5888	Gene	Gene	domains|nmod|START_ENTITY mutations|nmod|domains affect|nsubj|mutations affect|dobj|recombination recombination|acl|induced induced|nmod|END_ENTITY	Cancer-associated mutations in BRC domains of BRCA2 affect homologous recombination induced by Rad51 .
26387543	0	BRCA2	79,84	cyclin_A	58,66	BRCA2	cyclin A	675	890	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Cyclin_D1 promotes BRCA2-Rad51 interaction by restricting cyclin_A / B-dependent BRCA2 phosphorylation .
10749118	0	BRCA2	18,23	hBUBR1	73,79	BRCA2	hBUBR1	675	701	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1 .
19709076	0	BRCA2	0,5	plectin	53,60	BRCA2	plectin	675	5339	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization .
12809554	0	BRCA2-associated_factor_35	63,89	kinesin_superfamily_protein_member_4	21,57	BRCA2-associated factor 35	kinesin superfamily protein member 4	10362	24137	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human kinesin_superfamily_protein_member_4 with BRCA2-associated_factor_35 .
26349765	0	BRD2	22,26	PAI-1	54,59	BRD2	PAI-1	14312(Tax:10090)	18787(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	The Epigenetic Reader BRD2 as a Specific Modulator of PAI-1 Expression in Lipopolysaccharide-Stimulated Mouse Primary Astrocytes .
25535366	0	BRD4	69,73	BET	44,47	BRD4	BET	23476	92737	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	An in-tumor genetic screen reveals that the BET bromodomain protein , BRD4 , is a potential therapeutic target in ovarian_carcinoma .
26939702	0	BRD4	0,4	EZH2	15,19	BRD4	EZH2	23476	2146	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	BRD4 regulates EZH2 transcription through up-regulation of C-MYC and represents a novel therapeutic target in bladder_cancer .
26111795	0	BRD4	24,28	HOTAIR	38,44	BRD4	HOTAIR	23476	100124700	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	The Bromodomain protein BRD4 controls HOTAIR , a long noncoding RNA essential for glioblastoma proliferation .
26622824	0	BRD4	0,4	MMP-2	62,67	BRD4	MMP-2	23476	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway .
25146928	0	BRD4	0,4	Nanog	15,20	BRD4	Nanog	57261(Tax:10090)	71950(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos .
25684227	0	BRD4	22,26	OCT4	42,46	BRD4	OCT4	23476	5460	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	The BET Family Member BRD4 Interacts with OCT4 and Regulates Pluripotency Gene Expression .
24260471	0	BRD4	0,4	RRP1B	34,39	BRD4	RRP1B	57261(Tax:10090)	72462(Tax:10090)	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	BRD4 short isoform interacts with RRP1B , SIPA1 and components of the LINC complex at the inner face of the nuclear membrane .
24497639	0	BRD4	39,43	bromodomain_protein_4	16,37	BRD4	bromodomain protein 4	23476	23476	Gene	Gene	interactions|appos|START_ENTITY interactions|amod|END_ENTITY	Affinity map of bromodomain_protein_4 -LRB- BRD4 -RRB- interactions with the histone H4 tail and the small molecule inhibitor JQ1 .
20215511	0	BRD7	0,4	BRCA1	56,61	BRD7	BRCA1	29117	672	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	BRD7 , a subunit of SWI/SNF complexes , binds directly to BRCA1 and regulates BRCA1-dependent transcription .
12918109	0	BRD7	47,51	NAG-7	40,45	BRD7	NAG-7	29117	29931	Gene	Gene	Expression|appos|START_ENTITY Expression|amod|END_ENTITY	Expression of tumor related genes NGX6 , NAG-7 , BRD7 in gastric and colorectal_cancer .
19111069	0	BRD7	30,34	Sp1	49,52	BRD7	Sp1	29117	6667	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of BRD7 expression by Sp1 and c-Myc .
24198243	0	BRD7	63,67	bromodomain-containing_protein_7	29,61	BRD7	bromodomain-containing protein 7	26992(Tax:10090)	26992(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Tumor suppressive effects of bromodomain-containing_protein_7 -LRB- BRD7 -RRB- in epithelial_ovarian_carcinoma .
24840027	0	BRD7	86,90	bromodomain_containing_7	60,84	BRD7	bromodomain containing 7	29117	29117	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Targeting the anaphase-promoting complex/cyclosome -LRB- APC/C -RRB- - bromodomain_containing_7 -LRB- BRD7 -RRB- pathway for human osteosarcoma .
26565999	0	BRDT	12,16	BET	0,3	BRDT	BET	676	92737	Gene	Gene	START_ENTITY|nsubj|Protein Protein|compound|END_ENTITY	BET Protein BRDT Complexes with HDAC1 , PRMT5 and TRIM28 and Functions in Transcriptional Repression During Spermatogenesis .
20538714	0	BRDT	75,79	bromodomain_testis-specific	46,73	BRDT	bromodomain testis-specific	676	676	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The interaction of modified histones with the bromodomain_testis-specific -LRB- BRDT -RRB- gene and its mRNA level in sperm of fertile donors and subfertile men .
18390591	0	BREVIPEDICELLUS	36,51	KNAT6	15,20	BREVIPEDICELLUS	KNAT6	826364(Tax:3702)	838946(Tax:3702)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of KNAT6 and KNAT2 with BREVIPEDICELLUS and PENNYWISE in Arabidopsis inflorescences .
17582821	0	BRG1	82,86	ATPase	106,112	BRG1	ATPase	6597	1769	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein , a central ATPase of the SWI/SNF remodeling complex .
19789351	0	BRG1	84,88	ATPase	94,100	BRG1	ATPase	6597	1769	Gene	Gene	activity|nmod|START_ENTITY dependent|nmod|activity dependent|dep|END_ENTITY	Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1 , the ATPase of the SWI/SNF chromatin remodeling complex .
23406903	0	BRG1	0,4	COUP-TFII	14,23	BRG1	COUP-TFII	20586(Tax:10090)	11819(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development .
23082233	0	BRG1	21,25	E2F6	0,4	BRG1	E2F6	6597	1876	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	E2F6 associates with BRG1 in transcriptional regulation .
25486475	0	BRG1	0,4	HDAC2	81,86	BRG1	HDAC2	6597	3066	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRG1 , the ATPase subunit of SWI/SNF chromatin remodeling complex , interacts with HDAC2 to modulate telomerase expression in human cancer cells .
17723105	0	BRG1	55,59	HMGA1	0,5	BRG1	HMGA1	6597	3159	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	HMGA1 mediates the activation of the CRYAB promoter by BRG1 .
14530259	0	BRG1	26,30	Mi-2_beta	0,9	BRG1	Mi-2 beta	6597	1108	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Mi-2_beta associates with BRG1 and RET_finger_protein at the distinct regions with transcriptional activating and repressing abilities .
25724006	0	BRG1	31,35	NANOG	157,162	BRG1	NANOG	6597	79923	Gene	Gene	factor|compound|START_ENTITY expression|nmod|factor induces|nsubj|expression induces|dobj|senescence senescence|acl|associated associated|nmod|silencing silencing|nmod|END_ENTITY	De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins .
26416882	0	BRG1	0,4	Nanog	13,18	BRG1	Nanog	20586(Tax:10090)	71950(Tax:10090)	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation .
16923960	0	BRG1	0,4	Nrf2	20,24	BRG1	Nrf2	6597	4780	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress .
21102582	0	BRG1	75,79	PTEN	14,18	BRG1	PTEN	6597	5728	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal_carcinoma cells .
22162999	0	BRG1	27,31	SAF-A	0,5	BRG1	SAF-A	6597	3192	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription .
24421395	0	BRG1	85,89	SMARCA4	76,83	BRG1	SMARCA4	6597	6597	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Residual complexes containing SMARCA2 -LRB- BRM -RRB- underlie the oncogenic drive of SMARCA4 -LRB- BRG1 -RRB- mutation .
27100627	0	BRG1	17,21	SMARCA4	8,15	BRG1	SMARCA4	6597	6597	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	Loss of SMARCA4 -LRB- BRG1 -RRB- Protein Expression by Immunohistochemistry in Small Cell Carcinoma_of_the_Ovary , Hypercalcemic Type Distinguishes these Tumors from their Mimics .
19448667	0	BRG1	41,45	p53	73,76	BRG1	p53	6597	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells .
21543328	0	BRG1-associated_factor_57	73,98	Teashirt-3	0,10	BRG1-associated factor 57	Teashirt-3	57376(Tax:10090)	243931(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Teashirt-3 , a novel regulator of muscle differentiation , associates with BRG1-associated_factor_57 -LRB- BAF57 -RRB- to inhibit myogenin gene expression .
18177740	0	BRGl	86,90	Transcriptional_enhancer_factor_1	0,33	BRGl	Transcriptional enhancer factor 1	81616	7003	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Transcriptional_enhancer_factor_1 -LRB- TEF-1 / TEAD1 -RRB- mediates activation of IFITM3 gene by BRGl .
12150929	0	BRI1	70,74	BAK1	0,4	BRI1	BAK1	830095(Tax:3702)	829480(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BAK1 , an Arabidopsis LRR receptor-like protein kinase , interacts with BRI1 and modulates brassinosteroid signaling .
11320207	0	BRI1	43,47	BRS1	0,4	BRI1	BRS1	830095(Tax:3702)	829184(Tax:3702)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BRS1 , a serine carboxypeptidase , regulates BRI1 signaling in Arabidopsis_thaliana .
26808213	0	BRI1	75,79	DWARF1	33,39	BRI1	DWARF1	830095(Tax:3702)	821519(Tax:3702)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	Immunophilin-like FKBP42/TWISTED DWARF1 Interacts with the Receptor Kinase BRI1 to Regulate Brassinosteroid Signaling in Arabidopsis .
23627710	0	BRI2	0,4	BACE1	20,25	BRI2	BACE1	9445	23621	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	BRI2 Interacts with BACE1 and Reduces its Cellular Levels by Reducing the Levels of BACE1 mRNA and Inducing its Degradation Through the Lysosomal Pathway .
23701002	0	BRI2	0,4	BACE1	20,25	BRI2	BACE1	9445	23621	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels .
16027166	0	BRI2	0,4	amyloid_precursor_protein	20,45	BRI2	amyloid precursor protein	9445	351	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	BRI2 interacts with amyloid_precursor_protein -LRB- APP -RRB- and regulates amyloid beta -LRB- Abeta -RRB- production .
19366692	0	BRI2	121,125	amyloid_precursor_protein	14,39	BRI2	amyloid precursor protein	16432(Tax:10090)	11820(Tax:10090)	Gene	Gene	manner|nmod|START_ENTITY inhibits|nmod|manner inhibits|dobj|processing processing|compound|END_ENTITY	BRI3 inhibits amyloid_precursor_protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2 .
18452648	0	BRI3	0,4	SCG10	21,26	BRI3	SCG10	304284(Tax:10116)	84510(Tax:10116)	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells .
23225146	0	BRIP1	20,25	BACH1	27,32	BRIP1	BACH1	64979	571	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between BRIP1 -LRB- BACH1 -RRB- polymorphisms and breast_cancer risk : a meta-analysis .
23225146	0	BRIP1	20,25	BACH1	27,32	BRIP1	BACH1	64979	571	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between BRIP1 -LRB- BACH1 -RRB- polymorphisms and breast_cancer risk : a meta-analysis .
26315354	0	BRIP1	26,31	BARD1	33,38	BRIP1	BARD1	83990	580	Gene	Gene	PALB2|compound|START_ENTITY PALB2|appos|END_ENTITY	Germline Mutations in the BRIP1 , BARD1 , PALB2 , and NBN Genes in Women With Ovarian_Cancer .
21356067	0	BRIP1	42,47	BRCA1	14,19	BRIP1	BRCA1	83990	672	Gene	Gene	RAD50|appos|START_ENTITY RAD50|compound|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
25301947	0	BRIT1	74,79	hTERT	67,72	BRIT1	hTERT	79648	7015	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Phosphorylation of the BRCA1 C terminus -LRB- BRCT -RRB- repeat inhibitor of hTERT -LRB- BRIT1 -RRB- protein coordinates TopBP1 protein recruitment and amplifies ataxia_telangiectasia-mutated_and_Rad3-related -LRB- ATR -RRB- Signaling .
24523872	0	BRK	0,3	Dok1	12,16	BRK	Dok1	5753	1796	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration .
24680773	0	BRK1	32,36	Sp1	0,3	BRK1	Sp1	55845	6667	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sp1 transcriptionally regulates BRK1 expression in non-small_cell_lung_cancer cells .
11390628	0	BRLF1	43,48	CBP	64,67	BRLF1	CBP	17494186	1387	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Epstein-Barr_virus immediate-early protein BRLF1 interacts with CBP , promoting enhanced BRLF1 transactivation .
11390628	0	BRLF1	88,93	CBP	64,67	BRLF1	CBP	17494186	1387	Gene	Gene	transactivation|compound|START_ENTITY promoting|dobj|transactivation interacts|xcomp|promoting interacts|nmod|END_ENTITY	Epstein-Barr_virus immediate-early protein BRLF1 interacts with CBP , promoting enhanced BRLF1 transactivation .
26297580	0	BRLF1	49,54	USF1	58,62	BRLF1	USF1	17494186	7391	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of Epstein-Barr_virus BRLF1 by USF1 and Rta .
24596389	0	BRMS-1	113,119	BRMS-1	53,59	BRMS-1	BRMS-1	25855	25855	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of breast_cancer_metastasis_suppressor-1 , BRMS-1 , in human breast_cancer and the biological impact of BRMS-1 on the migration of breast_cancer cells .
24596389	0	BRMS-1	53,59	BRMS-1	113,119	BRMS-1	BRMS-1	25855	25855	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of breast_cancer_metastasis_suppressor-1 , BRMS-1 , in human breast_cancer and the biological impact of BRMS-1 on the migration of breast_cancer cells .
26730572	0	BRMS1	37,42	Cdk2	0,4	BRMS1	Cdk2	25855	1017	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cdk2 regulates metastasis suppressor BRMS1 .
26544623	0	BRMS1	99,104	Cullin3	0,7	BRMS1	Cullin3	25855	8452	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Cullin3 promotes breast_cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation .
26821020	0	BRMS1	89,94	ERa	0,3	BRMS1	ERa	25855	2099	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dobj|Expression	ERa Mediates Estrogen-Induced Expression of the Breast Cancer Metastasis Suppressor Gene BRMS1 .
25187687	0	BRMS1	85,90	breast_cancer_metastasis_suppressor_1	46,83	BRMS1	breast cancer metastasis suppressor 1	25855	25855	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Modelling and simulation of mutant alleles of breast_cancer_metastasis_suppressor_1 -LRB- BRMS1 -RRB- gene .
24984534	0	BRMS1	0,5	p65	47,50	BRMS1	p65	25855	5970	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	BRMS1 inhibits expression of NF-kappaB subunit p65 , uPA and OPN in ovarian_cancer cells .
23069940	0	BRN2	0,4	CDH13	39,44	BRN2	CDH13	5454	1012	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	BRN2 is a transcriptional repressor of CDH13 -LRB- T-cadherin -RRB- in melanoma cells .
11320207	0	BRS1	0,4	BRI1	43,47	BRS1	BRI1	829184(Tax:3702)	830095(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BRS1 , a serine carboxypeptidase , regulates BRI1 signaling in Arabidopsis_thaliana .
22798068	0	BRSK2	26,31	Brain-selective_kinase_2	0,24	BRSK2	Brain-selective kinase 2	75770(Tax:10090)	75770(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Brain-selective_kinase_2 -LRB- BRSK2 -RRB- phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic b-cells .
22798068	0	BRSK2	26,31	PCTAIRE1	52,60	BRSK2	PCTAIRE1	75770(Tax:10090)	18555(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Brain-selective_kinase_2 -LRB- BRSK2 -RRB- phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic b-cells .
12894593	0	BS69	34,38	Ets-2	0,5	BS69	Ets-2	10771	2114	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ets-2 interacts with co-repressor BS69 to repress target gene expression .
19795416	0	BS69	62,66	TICAM-1	13,20	BS69	TICAM-1	10771	148022	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Oligomerized TICAM-1 -LRB- TRIF -RRB- in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction .
20138174	0	BS69	0,4	TRAF3	21,26	BS69	TRAF3	10771	7187	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	BS69 cooperates with TRAF3 in the regulation of Epstein-Barr_virus-derived LMP1/CTAR1-induced NF-kappaB activation .
8664547	0	BSAP	12,16	Pax-5	18,23	BSAP	Pax-5	18507(Tax:10090)	18507(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of BSAP -LRB- Pax-5 -RRB- in B-cell development .
9442394	0	BSAP	30,34	Pax-5	23,28	BSAP	Pax-5	18507(Tax:10090)	18507(Tax:10090)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Essential functions of Pax-5 -LRB- BSAP -RRB- in pro-B cell development .
2951262	0	BSF-1	107,112	IL_2	145,149	BSF-1	IL 2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Bone_marrow_pro-T and pro-B lymphocyte clones express functional receptors for interleukin _ -LRB- IL -RRB- _ 3 and IL_4 / BSF-1 and nonfunctional receptors for IL_2 .
3097125	0	BSF-1	55,60	Interferon-gamma	0,16	BSF-1	Interferon-gamma	3565	3458	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Interferon-gamma suppresses B cell stimulation factor -LRB- BSF-1 -RRB- induction of class II MHC determinants on B cells .
2646299	0	BSF-1	57,62	MAF	69,72	BSF-1	MAF	16189(Tax:10090)	17132(Tax:10090)	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and sequencing of glycosylation variants of BSF-1 , as a MAF , from the EL-4 leukaemia cell line .
3495433	0	BSF-1	26,31	interleukin_4	12,25	BSF-1	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Recombinant interleukin_4 / BSF-1 promotes growth and differentiation of intrathymic T cell precursors from fetal mice in vitro .
2461199	0	BSF-2	184,189	IFN-beta_2	173,183	BSF-2	IFN-beta 2	3569	3569	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Inhibitory effect of human recombinant interferon gamma on synthesis of acute phase proteins in human hepatoma Hep G2 cells stimulated by leukocyte cytokines , TNF_alpha and IFN-beta_2 / BSF-2 / IL-6 .
2503436	1	BSF-2	163,168	IL-6	169,173	BSF-2	IL-6	3569	3569	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Synergistic effect of BSF-2 / IL-6 and IL-1 .
3171244	0	BSF-2	19,24	Interferon-beta_2	0,17	BSF-2	Interferon-beta 2	3569	3569	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Interferon-beta_2 -LRB- BSF-2 -RRB- mRNA is expressed in human monocytes .
2788466	0	BSF-2	47,52	interleukin-6	27,40	BSF-2	interleukin-6	3569	3569	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Pathogenic significance of interleukin-6 -LRB- IL-6 / BSF-2 -RRB- in Castleman 's _ disease .
19646679	0	BSND	40,44	DFNB73	19,25	BSND	DFNB73	7809	7809	Gene	Gene	mutations|nmod|START_ENTITY END_ENTITY|dep|mutations	Molecular basis of DFNB73 : mutations of BSND can cause nonsyndromic_deafness or Bartter_syndrome .
12397613	0	BSP	40,43	bone_sialoprotein	21,38	BSP	bone sialoprotein	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TNF-alpha suppresses bone_sialoprotein -LRB- BSP -RRB- expression in ROS17/2 .8 cells .
12766167	0	BSP	47,50	bone_sialoprotein	28,45	BSP	bone sialoprotein	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prostaglandin_E2 stimulates bone_sialoprotein -LRB- BSP -RRB- expression through cAMP and fibroblast_growth_factor_2 response elements in the proximal promoter of the rat BSP gene .
16171436	0	BSP	41,44	bone_sialoprotein	22,39	BSP	bone sialoprotein	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Amelogenin stimulates bone_sialoprotein -LRB- BSP -RRB- expression through fibroblast_growth_factor_2 response element and transforming_growth_factor-beta1 activation element in the promoter of the BSP gene .
16187297	0	BSP	33,36	bone_sialoprotein	14,31	BSP	bone sialoprotein	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of bone_sialoprotein -LRB- BSP -RRB- gene transcription by lipopolysaccharide .
16642470	0	BSP	58,61	bone_sialoprotein	39,56	BSP	bone sialoprotein	3381	3381	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor-I increases bone_sialoprotein -LRB- BSP -RRB- expression through fibroblast_growth_factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene .
2072878	0	BSP	35,38	bone_sialoprotein	16,33	BSP	bone sialoprotein	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of bone_sialoprotein -LRB- BSP -RRB- expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization .
7601099	0	BSP	48,51	bone_sialoprotein	29,46	BSP	bone sialoprotein	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Glucocorticoid regulation of bone_sialoprotein -LRB- BSP -RRB- gene expression .
8419459	0	BSP	35,38	bone_sialoprotein	16,33	BSP	bone sialoprotein	3381	24477(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of bone_sialoprotein -LRB- BSP -RRB- to Golgi and post-Golgi secretory structures in osteoblasts and to discrete sites in early bone matrix .
9084640	0	BSP	43,46	bone_sialoprotein	24,41	BSP	bone sialoprotein	3381	3381	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the bone_sialoprotein -LRB- BSP -RRB- gene promoter .
26084664	0	BSP5	76,80	binder_of_SPerm_5	57,74	BSP5	binder of SPerm 5	317699(Tax:9913)	317699(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Functional characterization of the domains of the bovine binder_of_SPerm_5 -LRB- BSP5 -RRB- protein .
24435510	0	BSPH1	52,57	Binder_of_SPerm_Homolog_1	25,50	BSPH1	Binder of SPerm Homolog 1	100131137	100131137	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Implication of the human Binder_of_SPerm_Homolog_1 -LRB- BSPH1 -RRB- protein in capacitation .
16380433	0	BSPRY	18,23	TRPV5	64,69	BSPRY	TRPV5	192120(Tax:10090)	194352(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity .
8921417	0	BST-1	35,40	BP-3	41,45	BST-1	BP-3	12182(Tax:10090)	12182(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Stage-specific expression of mouse BST-1 / BP-3 on the early B and T cell progenitors prior to gene rearrangement of antigen receptor .
23240078	0	BST-2	16,21	IL-27	0,5	BST-2	IL-27	684	246778	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN .
22065321	0	BST-2	0,5	MT1-MMP	28,35	BST-2	MT1-MMP	684	4323	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity .
26566124	0	BST-2	18,23	Tetherin	24,32	BST-2	Tetherin	69550(Tax:10090)	69550(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|Factor Factor|nsubj|END_ENTITY	Endogenous Murine BST-2 / Tetherin Is Not a Major Restriction Factor of Influenza_A_Virus Infection .
27042298	0	BST-2	12,17	Tetherin	18,26	BST-2	Tetherin	684	684	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of BST-2 / Tetherin in host protection and disease manifestation .
20485522	0	BST-2	46,51	tetherin	52,60	BST-2	tetherin	684	684	Gene	Gene	/|amod|START_ENTITY END_ENTITY|amod|/	The great escape : viral strategies to counter BST-2 / tetherin .
23840623	0	BST2	27,31	Tetherin	33,41	BST2	Tetherin	684	684	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Aberrant regulation of the BST2 -LRB- Tetherin -RRB- promoter enhances cell proliferation and apoptosis evasion in high grade breast_cancer cells .
17220202	0	BT2	43,46	TELOMERASE_ACTIVATOR1	70,91	BT2	TELOMERASE ACTIVATOR1	823994(Tax:3702)	820085(Tax:3702)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Regulation of telomerase in Arabidopsis by BT2 , an apparent target of TELOMERASE_ACTIVATOR1 .
15509807	0	BTAF1	24,29	NC2alpha	0,8	BTAF1	NC2alpha	9044	10589	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding_protein .
24793055	0	BTB	70,73	BCL6	65,69	BTB	BCL6	604	604	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Molecular dynamics analysis of the interaction between the human BCL6 BTB domain and its SMRT , NcoR and BCOR corepressors : the quest for a consensus dynamic pharmacophore .
18045867	0	BTEB1	58,63	basic_transcription_element-binding_protein_1	11,56	BTEB1	basic transcription element-binding protein 1	373598(Tax:8355)	373598(Tax:8355)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for basic_transcription_element-binding_protein_1 -LRB- BTEB1 -RRB- in the autoinduction of thyroid_hormone_receptor_beta .
9325059	0	BTF3	46,50	BTF3	75,79	BTF3	BTF3	689	689	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The visual assignment of genes by fiber-fish : BTF3 protein homologue gene -LRB- BTF3 -RRB- and a novel pseudogene of human RNA_helicase_A -LRB- DDX9P -RRB- on 13q22 .
9325059	0	BTF3	75,79	BTF3	46,50	BTF3	BTF3	689	689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The visual assignment of genes by fiber-fish : BTF3 protein homologue gene -LRB- BTF3 -RRB- and a novel pseudogene of human RNA_helicase_A -LRB- DDX9P -RRB- on 13q22 .
23029305	0	BTF3	101,105	basic_transcription_factor_3	71,99	BTF3	basic transcription factor 3	689	689	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human beta casein fragment -LRB- 54-59 -RRB- modulates M. bovis BCG survival and basic_transcription_factor_3 -LRB- BTF3 -RRB- expression in THP-1 cell line .
26396236	0	BTG1	49,53	B-cell_translocation_gene_1	20,47	BTG1	B-cell translocation gene 1	12226(Tax:10090)	12226(Tax:10090)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	A novel function of B-cell_translocation_gene_1 -LRB- BTG1 -RRB- in the regulation of hepatic_insulin_sensitivity in mice via c-Jun .
25936765	0	BTG1	110,114	MicroRNA-19a	0,12	BTG1	MicroRNA-19a	694	406979	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-19a regulates proliferation and apoptosis of castration-resistant_prostate_cancer cells by targeting BTG1 .
23583382	0	BTG2	49,53	GSK3b	84,89	BTG2	GSK3b	7832	2932	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Signals regulating necrosis of cardiomyoblast by BTG2 -LRB- / TIS21/PC3 -RRB- via activation of GSK3b and opening of mitochondrial permeability transition pore in response to H2O2 .
20569234	0	BTG2	0,4	Pin1	17,21	BTG2	Pin1	7832	5300	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence .
22266859	0	BTG2	34,38	miR-32	19,25	BTG2	miR-32	7832	407036	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant_prostate_cancer .
17690688	0	BTG3	31,35	p53	67,70	BTG3	p53	10950	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1 .
17301411	0	BTK	41,44	Bruton_Tyrosine_Kinase	17,39	BTK	Bruton Tyrosine Kinase	695	695	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Screening of the Bruton_Tyrosine_Kinase -LRB- BTK -RRB- Gene Mutations in 13 Iranian Patients with Presumed X-Linked_Agammaglobulinemia .
23360303	0	BTK	28,31	Bruton_tyrosine_kinase	4,26	BTK	Bruton tyrosine kinase	695	695	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The Bruton_tyrosine_kinase -LRB- BTK -RRB- inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse_large-B_cell_lymphoma -LRB- DLBCL -RRB- and mantle_cell_lymphoma -LRB- MCL -RRB- cells sensitive or resistant to bortezomib .
19426226	0	BTLA	11,15	CD160	4,9	BTLA	CD160	151888	11126	Gene	Gene	pathway|appos|START_ENTITY pathway|compound|END_ENTITY	The CD160 , BTLA , LIGHT/HVEM pathway : a bidirectional switch regulating T-cell activation .
25575067	0	BTLA	44,48	CD19	63,67	BTLA	CD19	151888	930	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- Xinfeng Capsule increases peripheral blood BTLA expression of CD19 -LRB- + -RRB- and CD24 -LRB- + -RRB- B cells and relieves oxidative stress damage to improve cardiac function of patients with rheumatoid_arthritis -RSB- .
23067542	0	BTLA	48,52	HVEM	68,72	BTLA	HVEM	151888	8764	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	The intrahepatic expression and distribution of BTLA and its ligand HVEM in patients with HBV-related acute-on-chronic_liver_failure .
24205057	0	BTLA	0,4	HVEM	22,26	BTLA	HVEM	208154(Tax:10090)	230979(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	BTLA interaction with HVEM expressed on CD8 -LRB- + -RRB- T cells promotes survival and memory generation in response to a bacterial_infection .
12242018	0	BUB3	84,88	budding_uninhibited_by_benomyl	52,82	BUB3	budding uninhibited by benomyl	9184	9184	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Molecular cloning and characterization of the human budding_uninhibited_by_benomyl -LRB- BUB3 -RRB- promoter .
26398519	0	BUB3	84,88	p16	90,93	BUB3	p16	9184	1029	Gene	Gene	Ki67|compound|START_ENTITY Ki67|dep|END_ENTITY	In situ carcinoma developed over_oral_lichen_planus : a case report with analysis of BUB3 , p16 , p53 , Ki67 and SOX4 expression .
26398519	0	BUB3	84,88	p53	95,98	BUB3	p53	9184	7157	Gene	Gene	Ki67|compound|START_ENTITY Ki67|dep|END_ENTITY	In situ carcinoma developed over_oral_lichen_planus : a case report with analysis of BUB3 , p16 , p53 , Ki67 and SOX4 expression .
23789096	0	BUBR1	0,5	PP2A	15,19	BUBR1	PP2A	701	5524	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression .
1905981	0	BUD5	6,10	BEM1	131,135	BUD5	BEM1	850405(Tax:4932)	852499(Tax:4932)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	Yeast BUD5 , encoding a putative GDP-GTP exchange factor , is necessary for bud site selection and interacts with bud formation gene BEM1 .
12515721	0	BV8	25,28	CD8	20,23	BV8	CD8	60675	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Clonal expansion of CD8 + BV8 T lymphocytes in bone marrow characterizes thymoma-associated B_lymphopenia .
25493215	0	BV8	62,65	EL4	90,93	BV8	EL4	50501(Tax:10090)	111979(Tax:10090)	Gene	Gene	PROTEIN|compound|START_ENTITY PROTEIN|nmod|END_ENTITY	GRANULOCYTE INFILTRATION AND EXPRESSION OF THE PRO-ANGIOGENIC BV8 PROTEIN IN EXPERIMENTAL EL4 AND LEWIS LUNG CARCINOMA TUMORS .
10400751	0	BZLF1	23,28	CREB-binding_protein	102,122	BZLF1	CREB-binding protein	3783744(Tax:10376)	1387	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The Epstein-Barr_virus BZLF1 protein interacts physically and functionally with the histone acetylase CREB-binding_protein .
24598729	0	BZLF1	24,29	MCAF1	0,5	BZLF1	MCAF1	3783744(Tax:10376)	55729	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	MCAF1 and Rta-activated BZLF1 transcription in Epstein-Barr_virus .
10849009	0	BZLF1	88,93	RACK1	26,31	BZLF1	RACK1	3783744(Tax:10376)	10399	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The PKC targeting protein RACK1 interacts with the Epstein-Barr_virus activator protein BZLF1 .
12114546	0	BZR1	58,62	BIN2	21,25	BZR1	BIN2	843845(Tax:3702)	827605(Tax:3702)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The GSK3-like kinase BIN2 phosphorylates and destabilizes BZR1 , a positive regulator of the brassinosteroid signaling pathway in Arabidopsis .
26363272	0	BZR1	0,4	HY5	20,23	BZR1	HY5	843845(Tax:3702)	830996(Tax:3702)	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	BZR1 Interacts with HY5 to Mediate Brassinosteroid - and Light-Regulated Cotyledon Opening in Arabidopsis in Darkness .
26600308	0	B_Cell-Activating_Factor	17,41	BAFF	43,47	B Cell-Activating Factor	BAFF	10673	10673	Gene	Gene	Levels|compound|START_ENTITY Levels|appos|END_ENTITY	Changes in Blood B_Cell-Activating_Factor -LRB- BAFF -RRB- Levels in Multiple_Sclerosis : A Sign of Treatment Outcome .
26829983	0	B_Cell_Activation	61,78	LLT1	0,4	B Cell Activation	LLT1	29760	29121	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	LLT1 and CD161 Expression in Human Germinal Centers Promotes B_Cell_Activation and CXCR4 Downregulation .
15647361	0	B_and_T_lymphocyte_attenuator	74,103	CD28	37,41	B and T lymphocyte attenuator	CD28	151888	940	Gene	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	A coreceptor interaction between the CD28 and TNF_receptor family members B_and_T_lymphocyte_attenuator and herpesvirus entry mediator .
17607320	0	B_and_T_lymphocyte_attenuator	0,29	CD3zeta	45,52	B and T lymphocyte attenuator	CD3zeta	151888	919	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	B_and_T_lymphocyte_attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation .
16272294	0	B_and_T_lymphocyte_attenuator	23,52	CD4	67,70	B and T lymphocyte attenuator	CD4	151888	920	Gene	Gene	analysis|nmod|START_ENTITY engagement|nsubj|analysis engagement|nmod|+ +|compound|END_ENTITY	Functional analysis of B_and_T_lymphocyte_attenuator engagement on CD4 + and CD8 + T cells .
19892849	0	B_and_T_lymphocyte_attenuator	35,64	CD4	97,100	B and T lymphocyte attenuator	CD4	208154(Tax:10090)	12504(Tax:10090)	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|nmod|synapse synapse|nmod|cells cells|compound|END_ENTITY	Activation-induced accumulation of B_and_T_lymphocyte_attenuator at the immunological synapse in CD4 + T cells .
21042564	0	B_and_T_lymphocyte_attenuator	19,48	CD4	82,85	B and T lymphocyte attenuator	CD4	208154(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|preventing preventing|dobj|development development|nmod|herpetic herpetic|compound|END_ENTITY	A crucial role for B_and_T_lymphocyte_attenuator in preventing the development of CD4 + T cell-mediated herpetic stromal_keratitis .
24289156	0	B_and_T_lymphocyte_attenuator	0,29	CD4	44,47	B and T lymphocyte attenuator	CD4	151888	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	B_and_T_lymphocyte_attenuator expression on CD4 + T-cells associates with sepsis and subsequent infections in ICU patients .
26329820	0	B_and_T_lymphocyte_attenuator	4,33	CD4	48,51	B and T lymphocyte attenuator	CD4	151888	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Low B_and_T_lymphocyte_attenuator expression on CD4 -LRB- + -RRB- T cells in the early stage of sepsis is associated with the severity and mortality of septic patients : a prospective cohort study .
23479601	0	B_and_T_lymphocyte_attenuator	0,29	Toll-like_receptor_4	82,102	B and T lymphocyte attenuator	Toll-like receptor 4	208154(Tax:10090)	21898(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	B_and_T_lymphocyte_attenuator inhibits LPS-induced endotoxic_shock by suppressing Toll-like_receptor_4 signaling in innate immune cells .
22725135	0	B_cell-activating_factor	0,24	interleukin-6	34,47	B cell-activating factor	interleukin-6	10673	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	B_cell-activating_factor enhances interleukin-6 and interleukin-10 production by ODN-activated human B cells .
17852877	0	B_cell-activating_factor	9,33	tumour_necrosis_factor	41,63	B cell-activating factor	tumour necrosis factor	10673	7124	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	Elevated B_cell-activating_factor of the tumour_necrosis_factor family in coeliac_disease .
11554781	0	B_cell-attracting_chemokine_1	6,35	CXCR3_receptor	80,94	B cell-attracting chemokine 1	CXCR3 receptor	10563	2833	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	Human B_cell-attracting_chemokine_1 -LRB- BCA-1 ; CXCL13 -RRB- is an agonist for the human CXCR3_receptor .
18172866	0	B_cell-specific_activator_protein	73,106	1-cys_peroxiredoxin	41,60	B cell-specific activator protein	1-cys peroxiredoxin	18507(Tax:10090)	11758(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the murine 1-cys_peroxiredoxin gene by the B_cell-specific_activator_protein , Pax5 .
16891199	0	B_cell-specific_activator_protein	14,47	PAX5	48,52	B cell-specific activator protein	PAX5	5079	5079	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of B_cell-specific_activator_protein / PAX5 in acute_myeloid_leukemia with t -LRB- 8 ; 21 -RRB- -LRB- q22 ; q22 -RRB- .
25479221	0	B_cell_Activating_Factor	12,36	BAFF	38,42	B cell Activating Factor	BAFF	10673	10673	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The role of B_cell_Activating_Factor -LRB- BAFF -RRB- expression on pathogenesis of nasal_polyp in chronic rhinosinusitis with nasal_polyposis .
24459141	0	B_cell_Leukemia_3	31,48	Bcl-3	50,55	B cell Leukemia 3	Bcl-3	602	602	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Inhibition of transcription by B_cell_Leukemia_3 -LRB- Bcl-3 -RRB- protein requires interaction with nuclear factor kB -LRB- NF-kB -RRB- p50 .
2972394	0	B_cell_activating_factor	49,73	IL-4	0,4	B cell activating factor	IL-4	24099(Tax:10090)	16189(Tax:10090)	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	IL-4 , but not IL-5 , can act synergistically with B_cell_activating_factor -LRB- BCAF -RRB- to induce proliferation of resting B cells .
7722292	0	B_cell_activation	27,44	IL-10	12,17	B cell activation	IL-10	29760	3586	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of IL-10 in human B_cell_activation , proliferation , and differentiation .
18652679	0	B_cell_activation	20,37	TLR7	41,45	B cell activation	TLR7	29760	51284	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of human B_cell_activation by TLR7 and TLR9 agonists .
6602846	0	B_cell_activation	38,55	interleukin_1	15,28	B cell activation	interleukin 1	29760	3552	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of interleukin_1 on human B_cell_activation and proliferation .
3091378	0	B_cell_activation	57,74	interleukin_2	13,26	B cell activation	interleukin 2	29760	3558	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of interleukin_2 and interferon-gamma in human B_cell_activation , growth and differentiation .
14610042	0	B_cell_antigen_receptor	4,27	Btk	63,66	B cell antigen receptor	Btk	613	695	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	The B_cell_antigen_receptor controls integrin activity through Btk and PLCgamma2 .
11745400	0	B_cell_antigen_receptor	48,71	CD40	17,21	B cell antigen receptor	CD40	613	958	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	The influence of CD40 on the association of the B_cell_antigen_receptor with lipid rafts in mature and immature cells .
12771181	0	B_cell_antigen_receptor	27,50	Cbl-b	0,5	B cell antigen receptor	Cbl-b	110279(Tax:10090)	208650(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cbl-b negatively regulates B_cell_antigen_receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk .
10385529	0	B_cell_antigen_receptor	51,74	protein_kinase_B	16,32	B cell antigen receptor	protein kinase B	613	2185	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	The dynamics of protein_kinase_B regulation during B_cell_antigen_receptor engagement .
12036603	0	B_cell_antigen_receptor	106,129	protein_kinase_C-epsilon	74,98	B cell antigen receptor	protein kinase C-epsilon	613	5581	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation and phosphatidylinositol 3-kinase-dependent phosphorylation of protein_kinase_C-epsilon by the B_cell_antigen_receptor .
3917482	0	B_cell_differentiation_factor	10,39	BCDF	41,45	B cell differentiation factor	BCDF	3569	3569	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of B_cell_differentiation_factor -LRB- BCDF -RRB- on biosynthesis and secretion of immunoglobulin molecules in human B cell lines .
10583957	0	B_cell_linker_protein	16,37	BLNK	39,43	B cell linker protein	BLNK	17060(Tax:10090)	17060(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|appos|END_ENTITY	Requirement for B_cell_linker_protein -LRB- BLNK -RRB- in B cell development .
10880534	0	B_cell_maturation_antigen	63,88	BAFF	0,4	B cell maturation antigen	BAFF	608	10673	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	BAFF binds to the tumor necrosis factor receptor-like molecule B_cell_maturation_antigen and is important for maintaining the peripheral B cell population .
10908663	0	B_cell_maturation_protein	0,25	TALL-1	84,90	B cell maturation protein	TALL-1	608	10673	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	B_cell_maturation_protein is a receptor for the tumor necrosis factor family member TALL-1 .
2958544	0	B_cell_stimulatory_factor-1	10,37	interleukin_4	39,52	B cell stimulatory factor-1	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of B_cell_stimulatory_factor-1 -LRB- interleukin_4 -RRB- on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines .
3496134	0	B_cell_stimulatory_factor-1	11,38	interleukin_4	39,52	B cell stimulatory factor-1	interleukin 4	3565	3565	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of B_cell_stimulatory_factor-1 / interleukin_4 on hematopoietic_progenitor_cells .
3500217	0	B_cell_stimulatory_factor_1	8,35	interleukin_4	36,49	B cell stimulatory factor 1	interleukin 4	3565	3565	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of B_cell_stimulatory_factor_1 / interleukin_4 in clonal proliferation of B cells .
2836512	1	B_cell_stimulatory_factor_2	98,125	IFN-beta_2	87,97	B cell stimulatory factor 2	IFN-beta 2	3569	3569	Gene	Gene	Role|parataxis|START_ENTITY Role|nmod|END_ENTITY	Role of IFN-beta_2 / B_cell_stimulatory_factor_2 / IL-6 .
26738493	0	B_cell_translocation_gene_2	0,27	Stat3	51,56	B cell translocation gene 2	Stat3	12227(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	B_cell_translocation_gene_2 -LRB- Btg2 -RRB- is regulated by Stat3 signaling and inhibits adipocyte differentiation .
9687529	0	B_lymphocyte-induced_maturation_protein	23,62	Blimp-1	64,71	B lymphocyte-induced maturation protein	Blimp-1	639	639	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Differential effect of B_lymphocyte-induced_maturation_protein -LRB- Blimp-1 -RRB- expression on cell fate during B cell development .
20478695	0	B_lymphocyte-induced_maturation_protein_1	0,41	aryl_hydrocarbon_receptor	68,93	B lymphocyte-induced maturation protein 1	aryl hydrocarbon receptor	12142(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	B_lymphocyte-induced_maturation_protein_1 is a novel target gene of aryl_hydrocarbon_receptor .
12204275	0	B_lymphocyte_induced_maturation_protein-1	34,75	Blimp-1	77,84	B lymphocyte induced maturation protein-1	Blimp-1	12142(Tax:10090)	12142(Tax:10090)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	The dynamic expression pattern of B_lymphocyte_induced_maturation_protein-1 -LRB- Blimp-1 -RRB- during mouse embryonic development .
18155301	0	B_lymphocyte_stimulator	46,69	B-cell-activating_factor	14,38	B lymphocyte stimulator	B-cell-activating factor	10673	10673	Gene	Gene	expression|compound|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of B-cell-activating_factor -LRB- BAFF -RRB- / B_lymphocyte_stimulator -LRB- BLyS -RRB- expression in human neutrophils .
23242501	0	B_lymphocyte_stimulator	13,36	BCMA	101,105	B lymphocyte stimulator	BCMA	10673	608	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	An optimized B_lymphocyte_stimulator -LRB- BLyS -RRB- antagonist peptide inhibits the interaction of BLyS with BCMA .
12192248	0	B_lymphocyte_stimulator	68,91	BLyS	62,66	B lymphocyte stimulator	BLyS	10673	10673	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Systemic_lupus_erythematosus : a blissless disease of too much BLyS -LRB- B_lymphocyte_stimulator -RRB- protein .
14597212	0	B_lymphocyte_stimulator	80,103	BLyS	105,109	B lymphocyte stimulator	BLyS	10673	10673	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	B lymphocytes from individuals with common_variable_immunodeficiency respond to B_lymphocyte_stimulator -LRB- BLyS protein -RRB- in vitro .
18155301	0	B_lymphocyte_stimulator	46,69	BLyS	71,75	B lymphocyte stimulator	BLyS	10673	10673	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulation of B-cell-activating_factor -LRB- BAFF -RRB- / B_lymphocyte_stimulator -LRB- BLyS -RRB- expression in human neutrophils .
19411764	0	B_lymphocyte_stimulator	12,35	BLyS	37,41	B lymphocyte stimulator	BLyS	10673	10673	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of B_lymphocyte_stimulator -LRB- BLyS -RRB- in systemic_lupus_erythematosus .
21883351	0	B_lymphocyte_stimulator	28,51	BLyS	58,62	B lymphocyte stimulator	BLyS	10673	10673	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Promoter -817 C > T variant of B_lymphocyte_stimulator gene -LRB- BLyS -RRB- and susceptibility to endometriosis-related_infertility and idiopathic infertility in Brazilian population .
12461691	0	B_melanoma_antigen	10,28	BAGE	4,8	B melanoma antigen	BAGE	574	574	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	New BAGE -LRB- B_melanoma_antigen -RRB- genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile .
15465821	0	Bach-1	8,14	heme_oxygenase-1	32,48	Bach-1	heme oxygenase-1	571	3162	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of Bach-1 in regulation of heme_oxygenase-1 in human liver cells : insights from studies with small interfering RNAS .
25019514	0	Bach1	72,77	HMOX1	31,36	Bach1	HMOX1	571	3162	Gene	Gene	activity|amod|START_ENTITY modulator|nmod|activity Induction|dep|modulator Induction|nmod|I I|appos|END_ENTITY	Induction of heme oxygenase I -LRB- HMOX1 -RRB- by HPP-4382 : a novel modulator of Bach1 activity .
26244607	0	Bach1	63,68	HMOX1	43,48	Bach1	HMOX1	571	3162	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2 : Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line .
26244607	0	Bach1	63,68	HMOX1	43,48	Bach1	HMOX1	571	3162	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2 : Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line .
19874887	0	Bach1	11,16	HO-1	66,70	Bach1	HO-1	571	3162	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes .
23738048	0	Bach1	115,120	Nrf2	18,22	Bach1	Nrf2	571	4780	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|pathway pathway|amod|END_ENTITY	Activation of the Nrf2 pathway by inorganic arsenic in human hepatocytes and the role of transcriptional repressor Bach1 .
15464985	0	Bach1	94,99	alpha-globin	36,48	Bach1	alpha-globin	571	3040	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells .
12356737	0	Bach1	12,17	heme_oxygenase-1	53,69	Bach1	heme oxygenase-1	12013(Tax:10090)	15368(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|availability availability|nmod|gene gene|amod|END_ENTITY	Hemoprotein Bach1 regulates enhancer availability of heme_oxygenase-1 gene .
12511571	0	Bach1	0,5	heme_oxygenase-1	57,73	Bach1	heme oxygenase-1	571	3162	Gene	Gene	functions|amod|START_ENTITY functions|nmod|gene gene|amod|END_ENTITY	Bach1 functions as a hypoxia-inducible repressor for the heme_oxygenase-1 gene in human cells .
17065227	0	Bach1	8,13	heme_oxygenase-1	47,63	Bach1	heme oxygenase-1	571	3162	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|amod|END_ENTITY	Role of Bach1 and Nrf2 in up-regulation of the heme_oxygenase-1 gene by cobalt_protoporphyrin .
18948842	0	Bach1	0,5	heme_oxygenase-1	16,32	Bach1	heme oxygenase-1	12013(Tax:10090)	15368(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Bach1 modulates heme_oxygenase-1 expression in the neonatal mouse lung .
20345481	0	Bach1	103,108	heme_oxygenase-1	14,30	Bach1	heme oxygenase-1	571	3162	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of heme_oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1 .
22698995	0	Bach1	60,65	heme_oxygenase-1	28,44	Bach1	heme oxygenase-1	571	3162	Gene	Gene	injury|amod|START_ENTITY suppressing|dobj|injury END_ENTITY|advcl|suppressing	The let-7 microRNA enhances heme_oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes .
24613086	0	Bach1	164,169	heme_oxygenase-1	55,71	Bach1	heme oxygenase-1	571	3162	Gene	Gene	degradation|appos|START_ENTITY importance|nmod|degradation Characterization|dep|importance Characterization|dep|expression expression|amod|END_ENTITY	Characterization of docosahexaenoic_acid -LRB- DHA -RRB- - induced heme_oxygenase-1 -LRB- HO-1 -RRB- expression in human cancer cells : the importance of enhanced BTB_and_CNC_homology_1 -LRB- Bach1 -RRB- degradation .
18256039	0	Bach2	67,72	Blimp-1	51,58	Bach2	Blimp-1	60468	639	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6 .
17018862	0	Bach2	112,117	PI-3	30,34	Bach2	PI-3	60468	5266	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	Bcr-Abl signaling through the PI-3 / S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2 , which represses the antiapoptotic factor heme_oxygenase-1 .
15060166	0	Bach2	86,91	PML	14,17	Bach2	PML	60468	5371	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2 .
26522720	0	Bach2	34,39	c-Rel	18,23	Bach2	c-Rel	12014(Tax:10090)	19696(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The NF-kB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell_lymphoma .
11390485	0	Bad	45,48	Bcl-2	0,5	Bad	Bcl-2	572	596	Gene	Gene	alpha|dep|START_ENTITY targets|xcomp|alpha targets|nsubj|END_ENTITY	Bcl-2 targets protein phosphatase 1 alpha to Bad .
14597423	0	Bad	120,123	Bcl-2	100,105	Bad	Bcl-2	572	596	Gene	Gene	START_ENTITY|nsubj|phosporylation phosporylation|nmod|member member|compound|END_ENTITY	The Us3 protein kinase of herpes_simplex_virus_1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad .
15751984	0	Bad	102,105	Bcl-2	72,77	Bad	Bcl-2	572	596	Gene	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad .
17557568	0	Bad	74,77	Bcl-2	55,60	Bad	Bcl-2	572	596	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|domains domains|nmod|genes genes|compound|END_ENTITY	Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad , Bmf and Bcl-G in laryngeal_squamous_cell_carcinomas .
21472231	0	Bad	154,157	Bcl-2	116,121	Bad	Bcl-2	572	596	Gene	Gene	Bak|dep|START_ENTITY apoptotic|appos|Bak apoptotic|dep|Immunoexpression Immunoexpression|nmod|family family|compound|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21472231	0	Bad	154,157	Bcl-2	130,135	Bad	Bcl-2	572	596	Gene	Gene	Bak|dep|START_ENTITY Bak|compound|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
7834748	0	Bad	0,3	Bcl-XL	33,39	Bad	Bcl-XL	572	598	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Bad , a heterodimeric partner for Bcl-XL and Bcl-2 , displaces Bax and promotes cell death .
17663748	0	Bad	47,50	Erk	94,97	Bad	Erk	64639(Tax:10116)	24338(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling .
25524600	0	Bad	79,82	estrogen_receptor_b	14,33	Bad	estrogen receptor b	572	2100	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Mitochondrial estrogen_receptor_b inhibits cell apoptosis via interaction with Bad in a ligand-independent manner .
25613618	0	Bad	107,110	estrogen_receptor_b	15,34	Bad	estrogen receptor b	572	2100	Gene	Gene	-RSB-|compound|START_ENTITY inhibits|nmod|-RSB- inhibits|nsubj|END_ENTITY	-LSB- Mitochondrial estrogen_receptor_b inhibits non-small_cell_lung_cancer cell apoptosis via interaction with Bad -RSB- .
17546604	0	Bag-1	48,53	Bcl-2_associated-athanogene-1	17,46	Bag-1	Bcl-2 associated-athanogene-1	573	573	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for Bcl-2_associated-athanogene-1 -LRB- Bag-1 -RRB- in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes .
11707401	0	Bag-1	14,19	p53	98,101	Bag-1	p53	573	7157	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Co-chaperones Bag-1 , Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53 .
26538564	0	Bag2	0,4	Pink1	28,33	Bag2	Pink1	9532	65018	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Bag2 Mediated Regulation of Pink1 is Critical for Mitochondrial Translocation of Parkin and Neuronal Survival .
21767525	0	Bag3	71,75	HspB8	57,62	Bag3	HspB8	9531	26353	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization of small heat_shock protein HspB8 -LRB- Hsp22 -RRB- - Bag3 interaction .
10369703	0	Bak	84,87	Bcl-2	105,110	Bak	Bcl-2	578	596	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Human right and left colon differ in epithelial cell apoptosis and in expression of Bak , a pro-apoptotic Bcl-2 homologue .
11278671	0	Bak	63,66	Bcl-2	16,21	Bak	Bcl-2	578	596	Gene	Gene	variant|nmod|START_ENTITY variant|compound|END_ENTITY	Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons , but pro-apoptotic in non-neuronal cells .
7715731	0	Bak	66,69	Bcl-2	50,55	Bak	Bcl-2	578	596	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak .
16254338	0	Bak	71,74	F1L	19,22	Bak	F1L	578	3707497(Tax:10245)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The vaccinia_virus F1L protein interacts with the proapoptotic protein Bak and inhibits Bak activation .
19955184	0	Bak	34,37	F1L	15,18	Bak	F1L	578	3707497(Tax:10245)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Vaccinia_virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1 .
16158421	0	Bak	17,20	JNK	33,36	Bak	JNK	578	5599	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric_oxide in human glioblastoma cells .
16116473	0	Bak	102,105	Lck	20,23	Bak	Lck	578	3932	Gene	Gene	expression|compound|START_ENTITY pathway|nmod|expression regulator|nmod|pathway regulator|nsubj|END_ENTITY	The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression .
16186791	0	Bak	26,29	Lck	21,24	Bak	Lck	578	3932	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	A novel link between Lck , Bak expression and chemosensitivity .
18371298	0	Bak	94,97	Lck	14,17	Bak	Lck	578	3932	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death .
23108666	0	Bak	20,23	Sirtuin-3	0,9	Bak	Sirtuin-3	578	23410	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Sirtuin-3 modulates Bak - and Bax-dependent apoptosis .
20851889	0	Bak	14,17	VDAC2	32,37	Bak	VDAC2	578	7417	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor .
20850481	0	Bak	16,19	ZBP-89	0,6	Bak	ZBP-89	578	7707	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular_carcinoma cells .
15077116	0	Bak	28,31	p53	14,17	Bak	p53	578	7157	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex .
15757910	0	Bak	28,31	voltage-dependent_anion_channel_2	35,68	Bak	voltage-dependent anion channel 2	578	7417	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bax-dependent regulation of Bak by voltage-dependent_anion_channel_2 .
25454784	0	Balboa	0,6	pickpocket	16,26	Balboa	pickpocket	38835(Tax:7227)	34843(Tax:7227)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae .
23526974	0	Bam	24,27	Mei-p26	0,7	Bam	Mei-p26	43038(Tax:7227)	45775(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Mei-p26 cooperates with Bam , Bgcn and Sxl to promote early germline development in the Drosophila ovary .
14563325	0	Bam32	0,5	ERK	35,38	Bam32	ERK	26377(Tax:10090)	26413(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival .
15247305	0	Bam32	20,25	Rac1	36,40	Bam32	Rac1	27071	5879	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism .
25359211	0	Bap1	0,4	Vhl	58,61	Bap1	Vhl	104416(Tax:10090)	22346(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis .
20551433	0	Bap170	0,6	EGFR	96,100	Bap170	EGFR	35560(Tax:7227)	37455(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Bap170 , a subunit of the Drosophila PBAP chromatin remodeling complex , negatively regulates the EGFR signaling .
12490554	0	Bapx1	23,28	Pax1	0,4	Bapx1	Pax1	12020(Tax:10090)	18503(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome .
26867008	0	Bardet-Biedl_Syndrome_5	20,43	BBS5	45,49	Bardet-Biedl Syndrome 5	BBS5	72569(Tax:10090)	72569(Tax:10090)	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	A Splice Variant of Bardet-Biedl_Syndrome_5 -LRB- BBS5 -RRB- Protein that Is Selectively Expressed in Retina .
15497446	0	Bardet-Biedl_syndrome_4	58,81	BBS4	88,92	Bardet-Biedl syndrome 4	BBS4	585	585	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a splice variant of human Bardet-Biedl_syndrome_4 gene -LRB- BBS4 -RRB- .
12843282	0	Barentsz	0,8	Staufen	115,122	Barentsz	Staufen	22794	37065(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Barentsz , a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells , interacts with Staufen in an RNA-dependent manner .
16215179	0	Bas1	10,14	Pho2	24,28	Bas1	Pho2	853974(Tax:4932)	851452(Tax:4932)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces_cerevisiae .
12114648	0	Basic_Fibroblast_Growth_Factor	0,30	Prolactin	49,58	Basic Fibroblast Growth Factor	Prolactin	2247	5617	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Basic_Fibroblast_Growth_Factor Expression by Two Prolactin and Thyrotropin-Producing Pituitary_Adenomas .
2061622	0	Basic_fibroblast_growth_factor	0,30	B-FGF	32,37	Basic fibroblast growth factor	B-FGF	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Basic_fibroblast_growth_factor -LRB- B-FGF -RRB- induces early - -LRB- CFU-s -RRB- and late-stage hematopoietic progenitor cell colony formation -LRB- CFU-gm , CFU-meg , and BFU-e -RRB- by synergizing with GM-CSF , Meg-CSF , and erythropoietin , and is a radioprotective agent in vitro .
9457070	0	Basic_fibroblast_growth_factor	0,30	Bcl-2	45,50	Basic fibroblast growth factor	Bcl-2	2247	596	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Basic_fibroblast_growth_factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast_cancer cells .
22943143	0	Basic_fibroblast_growth_factor	0,30	ERK1/2	90,96	Basic fibroblast growth factor	ERK1/2	2247	5595;5594	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Basic_fibroblast_growth_factor protects C17 .2 cells from radiation-induced injury through ERK1/2 .
10331422	0	Basic_fibroblast_growth_factor	0,30	KDR	67,70	Basic fibroblast growth factor	KDR	2247	3791	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Basic_fibroblast_growth_factor induces expression of VEGF receptor KDR through a protein_kinase_C and p44/p42 mitogen-activated protein kinase-dependent pathway .
8641215	0	Basic_fibroblast_growth_factor	0,30	LHRH	115,119	Basic fibroblast growth factor	LHRH	2247	2796	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Basic_fibroblast_growth_factor regulates the conversion of pro-luteinizing hormone-releasing hormone -LRB- Pro-LHRH -RRB- to LHRH in immortalized hypothalamic neurons .
12608905	0	Basic_fibroblast_growth_factor	0,30	MEK2	132,136	Basic fibroblast growth factor	MEK2	2247	5605	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Basic_fibroblast_growth_factor induces the expression of matrix_metalloproteinase-3 in human periodontal ligament cells through the MEK2 mitogen-activated protein kinase pathway .
14557270	0	Basic_fibroblast_growth_factor	0,30	Rac1	56,60	Basic fibroblast growth factor	Rac1	54250(Tax:10116)	363875(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Basic_fibroblast_growth_factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway .
11893917	0	Basic_fibroblast_growth_factor	0,30	TGF-beta	39,47	Basic fibroblast growth factor	TGF-beta	54250(Tax:10116)	59086(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Basic_fibroblast_growth_factor induces TGF-beta release in an isoform and glioma-specific manner .
10331422	0	Basic_fibroblast_growth_factor	0,30	VEGF	53,57	Basic fibroblast growth factor	VEGF	2247	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|KDR KDR|compound|END_ENTITY	Basic_fibroblast_growth_factor induces expression of VEGF receptor KDR through a protein_kinase_C and p44/p42 mitogen-activated protein kinase-dependent pathway .
25735814	0	Basic_fibroblast_growth_factor	0,30	VEGF	39,43	Basic fibroblast growth factor	VEGF	2247	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Basic_fibroblast_growth_factor induces VEGF expression in chondrosarcoma cells and subsequently promotes endothelial progenitor cell-primed angiogenesis .
8058201	0	Basic_fibroblast_growth_factor	0,30	c-fos	39,44	Basic fibroblast growth factor	c-fos	54250(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Basic_fibroblast_growth_factor induces c-fos expression in primary cultures of rat striatum .
10830307	0	Basic_fibroblast_growth_factor	0,30	collagenase-3	42,55	Basic fibroblast growth factor	collagenase-3	54250(Tax:10116)	171052(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Basic_fibroblast_growth_factor stimulates collagenase-3 promoter activity in osteoblasts through an activator_protein-1-binding site .
7776963	0	Basic_fibroblast_growth_factor	0,30	connexin-43	42,53	Basic fibroblast growth factor	connexin-43	2247	2697	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Basic_fibroblast_growth_factor stimulates connexin-43 expression and intercellular communication of cardiac fibroblasts .
15711060	0	Basic_fibroblast_growth_factor	0,30	cyclin_D1	69,78	Basic fibroblast growth factor	cyclin D1	54250(Tax:10116)	58919(Tax:10116)	Gene	Gene	exhibits|nsubj|START_ENTITY exhibits|dobj|regulation regulation|nmod|END_ENTITY	Basic_fibroblast_growth_factor exhibits dual and rapid regulation of cyclin_D1 and p27 to stimulate proliferation of rat cerebral cortical precursors .
12388177	0	Basic_fibroblast_growth_factor	0,30	cyclooxygenase-2	43,59	Basic fibroblast growth factor	cyclooxygenase-2	2247	5743	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	Basic_fibroblast_growth_factor upregulates cyclooxygenase-2 in I407 cells through p38 MAP kinase .
8117449	0	Basic_fibroblast_growth_factor	0,30	elastin	41,48	Basic fibroblast growth factor	elastin	54250(Tax:10116)	25043(Tax:10116)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|compound|END_ENTITY	Basic_fibroblast_growth_factor decreases elastin production by neonatal rat lung fibroblasts .
21130871	0	Basic_fibroblast_growth_factor	0,30	glial_cell-derived_neurotrophic_factor	40,78	Basic fibroblast growth factor	glial cell-derived neurotrophic factor	54250(Tax:10116)	25453(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Basic_fibroblast_growth_factor promotes glial_cell-derived_neurotrophic_factor gene expression mediated by activation of ERK5 in rat C6 glioma cells .
1385099	0	Basic_fibroblast_growth_factor	0,30	insulin-like_growth_factor-I	41,69	Basic fibroblast growth factor	insulin-like growth factor-I	2247	3479	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Basic_fibroblast_growth_factor modulates insulin-like_growth_factor-I , its receptor , and its binding proteins in hypothalamic cell cultures .
8247018	0	Basic_fibroblast_growth_factor	0,30	insulin-like_growth_factor-I	84,112	Basic fibroblast growth factor	insulin-like growth factor-I	2247	3479	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|cells cells|acl|overexpressing overexpressing|dobj|receptor receptor|amod|END_ENTITY	Basic_fibroblast_growth_factor stimulates DNA synthesis in cells overexpressing the insulin-like_growth_factor-I receptor .
9397941	0	Basic_fibroblast_growth_factor	0,30	insulin-like_growth_factor-I	98,126	Basic fibroblast growth factor	insulin-like growth factor-I	54250(Tax:10116)	24482(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|luteinizing luteinizing|dobj|expression expression|nmod|presence presence|nmod|END_ENTITY	Basic_fibroblast_growth_factor induces luteinizing hormone receptor expression in the presence of insulin-like_growth_factor-I in ovarian granulosa cells .
16320338	0	Basic_fibroblast_growth_factor	0,30	insulin-like_growth_factor_1	65,93	Basic fibroblast growth factor	insulin-like growth factor 1	2247	3479	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Basic_fibroblast_growth_factor inhibits the anabolic activity of insulin-like_growth_factor_1 and osteogenic_protein_1 in adult human articular chondrocytes .
9376229	0	Basic_fibroblast_growth_factor	0,30	interleukin-6	39,52	Basic fibroblast growth factor	interleukin-6	14173(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Basic_fibroblast_growth_factor induces interleukin-6 synthesis in osteoblasts : autoregulation by protein_kinase_C .
17311929	0	Basic_fibroblast_growth_factor	0,30	matrix_metalloproteinase-13	42,69	Basic fibroblast growth factor	matrix metalloproteinase-13	2247	4322	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Basic_fibroblast_growth_factor stimulates matrix_metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein_kinase_Cdelta pathways in human adult articular chondrocytes .
12608905	0	Basic_fibroblast_growth_factor	0,30	matrix_metalloproteinase-3	57,83	Basic fibroblast growth factor	matrix metalloproteinase-3	2247	4314	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Basic_fibroblast_growth_factor induces the expression of matrix_metalloproteinase-3 in human periodontal ligament cells through the MEK2 mitogen-activated protein kinase pathway .
7745622	0	Basic_fibroblast_growth_factor	0,30	myelin_basic_protein	46,66	Basic fibroblast growth factor	myelin basic protein	54250(Tax:10116)	24547(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	Basic_fibroblast_growth_factor down-regulates myelin_basic_protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro .
14555210	0	Basic_fibroblast_growth_factor	0,30	plasma_membrane_calcium_ATPase	56,86	Basic fibroblast growth factor	plasma membrane calcium ATPase	2247	491	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Basic_fibroblast_growth_factor -LRB- bFGF -RRB- regulation of the plasma_membrane_calcium_ATPase -LRB- PMCA -RRB- as part of an anti-apoptotic mechanism of action .
10330138	0	Basic_fibroblast_growth_factor	0,30	serum_response_factor	41,62	Basic fibroblast growth factor	serum response factor	2247	6722	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Basic_fibroblast_growth_factor activates serum_response_factor gene expression by multiple distinct signaling mechanisms .
9111519	0	Basic_fibroblast_growth_factor	0,30	transforming_growth_factor_beta_1	67,100	Basic fibroblast growth factor	transforming growth factor beta 1	2247	7040	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Basic_fibroblast_growth_factor stimulates the release of preformed transforming_growth_factor_beta_1 from human proximal tubular cells in the absence of de novo gene transcription or mRNA translation .
11327080	0	Basic_fibroblast_growth_factor	0,30	tropoelastin	42,54	Basic fibroblast growth factor	tropoelastin	2247	2006	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Basic_fibroblast_growth_factor suppresses tropoelastin gene expression in cultured human periodontal fibroblasts .
11127202	0	Basic_fibroblast_growth_factor	0,30	vascular_endothelial_growth_factor	42,76	Basic fibroblast growth factor	vascular endothelial growth factor	14173(Tax:10090)	22339(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Basic_fibroblast_growth_factor stimulates vascular_endothelial_growth_factor release in osteoblasts : divergent regulation by p42/p44 mitogen-activated protein kinase and p38 mitogen-activated protein kinase .
11263242	0	Basic_fibroblast_growth_factor	0,30	vascular_endothelial_growth_factor	62,96	Basic fibroblast growth factor	vascular endothelial growth factor	54250(Tax:10116)	83785(Tax:10116)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Basic_fibroblast_growth_factor up-regulates the expression of vascular_endothelial_growth_factor in primary cultured rat astrocytes .
21792931	0	Basigin	0,7	MCT1	28,32	Basigin	MCT1	12215(Tax:10090)	17236(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Basigin interacts with both MCT1 and MCT2 in murine spermatozoa .
18472156	0	Bax	45,48	14-3-3_zeta	67,78	Bax	14-3-3 zeta	581	7534	Gene	Gene	dissociation|compound|START_ENTITY dissociation|nmod|END_ENTITY	PKC_delta in preeclamptic placentas promotes Bax dissociation from 14-3-3_zeta through 14-3-3_zeta phosphorylation .
24819963	0	Bax	53,56	AP-1	82,86	Bax	AP-1	24887(Tax:10116)	24516(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
10758491	0	Bax	29,32	AtBI-1	0,6	Bax	AtBI-1	581	834758(Tax:3702)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	AtBI-1 , a plant homologue of Bax inhibitor-1 , suppresses Bax-induced cell death in yeast and is rapidly upregulated during wounding and pathogen challenge .
16600371	0	Bax	162,165	BCL-2	156,161	Bax	BCL-2	581	596	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Stress-induced in vitro apoptosis of native human acute_myelogenous_leukemia -LRB- AML -RRB- cells shows a wide variation between patients and is associated with low BCL-2 : Bax ratio and low levels of heat_shock protein 70 and 90 .
17318810	0	Bax	46,49	BCL-2	38,43	Bax	BCL-2	581	596	Gene	Gene	ratio|compound|START_ENTITY decreases|parataxis|ratio decreases|xcomp|END_ENTITY	Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells .
19439472	0	Bax	68,71	BCL-2	18,23	Bax	BCL-2	581	596	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|homologue homologue|compound|END_ENTITY	The fowlpox_virus BCL-2 homologue , FPV039 , interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis .
20422317	0	Bax	0,3	BCL-2	80,85	Bax	BCL-2	581	596	Gene	Gene	expression|compound|START_ENTITY remains|nsubj|expression remains|nmod|treatment treatment|acl|directed directed|nmod|END_ENTITY	Bax expression remains unchanged following antisense treatment directed against BCL-2 .
21471707	0	Bax	50,53	BK_channel	90,100	Bax	BK channel	24887(Tax:10116)	83731(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Activation of the permeability transition pore by Bax via inhibition of the mitochondrial BK_channel .
11726273	0	Bax	16,19	Bax	33,36	Bax	Bax	581	581	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|parataxis|triggered triggered|nsubj|heterodimer heterodimer|compound|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bax	33,36	Bax	16,19	Bax	Bax	581	581	Gene	Gene	heterodimer|compound|START_ENTITY triggered|nsubj|heterodimer Dissociation|parataxis|triggered Dissociation|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
8631771	0	Bax	21,24	Bax	75,78	Bax	Bax	581	581	Gene	Gene	heterodimerizes|nsubj|START_ENTITY heterodimerizes|nmod|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
8631771	0	Bax	75,78	Bax	21,24	Bax	Bax	581	581	Gene	Gene	heterodimerizes|nmod|START_ENTITY heterodimerizes|nsubj|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
10374878	0	Bax	75,78	Bcl-2	69,74	Bax	Bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY correlates|dep|expression correlates|nmod|END_ENTITY	Inhibition of constitutively activated Stat3 correlates with altered Bcl-2 / Bax expression and induction of apoptosis in mycosis_fungoides_tumor cells .
10381168	0	Bax	36,39	Bcl-2	18,23	Bax	Bcl-2	581	596	Gene	Gene	not|dep|START_ENTITY Downregulation|dep|not Downregulation|nmod|END_ENTITY	Downregulation of Bcl-2 , but not of Bax or Bcl-x , is associated with T lymphocyte apoptosis in HIV_infection and restored by antiretroviral therapy or by interleukin 2 .
10391451	0	Bax	7,10	Bcl-2	0,5	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	kainic_acid|nsubj|START_ENTITY kainic_acid|advmod|END_ENTITY	Bcl-2 , Bax and Bcl-x expression following kainic_acid administration at convulsant doses in the rat .
10395708	0	Bax	95,98	Bcl-2	89,94	Bax	Bcl-2	581	596	Gene	Gene	imbalance|compound|START_ENTITY imbalance|compound|END_ENTITY	Resistance of Crohn 's _ disease T cells to multiple apoptotic signals is associated with a Bcl-2 / Bax mucosal imbalance .
10400666	0	Bax	75,78	Bcl-2	27,32	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	heterodimerization|nmod|START_ENTITY functional|nmod|heterodimerization functional|nsubj|domain domain|nmod|END_ENTITY	NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis .
10472781	0	Bax	61,64	Bcl-2	55,60	Bax	Bcl-2	581	596	Gene	Gene	apoptosis|nsubj|START_ENTITY effects|parataxis|apoptosis effects|nmod|END_ENTITY	Differential effects of chemotherapeutic agents on the Bcl-2 / Bax apoptosis pathway in human breast_cancer cell line MCF-7 .
10554032	0	Bax	30,33	Bcl-2	108,113	Bax	Bcl-2	581	596	Gene	Gene	translocation|compound|START_ENTITY facilitates|dobj|translocation facilitates|nmod|mitochondria mitochondria|acl:relcl|involves involves|dobj|factor factor|acl|regulated regulated|nmod|END_ENTITY	Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2 .
10573132	0	Bax	0,3	Bcl-2	4,9	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|parataxis|important important|nsubj|modulation modulation|compound|END_ENTITY	Bax : Bcl-2 ratio modulation by bryostatin_1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute_lymphoblastic_leukemia cell line , Reh .
10591516	0	Bax	41,44	Bcl-2	35,40	Bax	Bcl-2	100355675(Tax:9986)	100009447(Tax:9986)	Gene	Gene	ratio|compound|START_ENTITY changes|dep|ratio changes|nmod|END_ENTITY	Age-related hippocampal changes in Bcl-2 : Bax ratio , oxidative stress , redox-active iron and apoptosis associated with aluminum-induced neurodegeneration : increased susceptibility with aging .
10628333	0	Bax	24,27	Bcl-2	18,23	Bax	Bcl-2	581	596	Gene	Gene	status|compound|START_ENTITY Alteration|dep|status Alteration|nmod|END_ENTITY	Alteration of the Bcl-2 / Bax status of head_and_neck_cancer cell lines by chemotherapeutic agents .
10641752	0	Bax	26,29	Bcl-2	20,25	Bax	Bcl-2	581	596	Gene	Gene	ratios|amod|START_ENTITY protein|dep|ratios protein|amod|END_ENTITY	Mutant p53 protein , Bcl-2 / Bax ratios and apoptosis in paediatric acute_lymphoblastic_leukaemia .
10658530	0	Bax	31,34	Bcl-2	8,13	Bax	Bcl-2	581	596	Gene	Gene	Role|dep|START_ENTITY Role|nmod|proteins proteins|compound|END_ENTITY	Role of Bcl-2 family proteins -LRB- Bax , Bcl-2 and Bcl-X -RRB- on cellular susceptibility to radiation in pancreatic_cancer cells .
10705244	0	Bax	7,10	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	Bcl-x|compound|START_ENTITY END_ENTITY|appos|Bcl-x	Bcl-2 , Bax , Bcl-x -LRB- L -RRB- and Bcl-x -LRB- S -RRB- expression in neoplastic and normal endometrium .
10751382	0	Bax	58,61	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	terminus|compound|START_ENTITY change|nmod|terminus inhibits|dobj|change inhibits|nsubj|END_ENTITY	Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation .
10806802	0	Bax	33,36	Bcl-2	26,31	Bax	Bcl-2	581	596	Gene	Gene	Fas/Apo|appos|START_ENTITY Fas/Apo|compound|END_ENTITY	The protein expression of Bcl-2 , Bax , Fas/Apo -1 in acute_myeloid_leukemia .
10806835	0	Bax	44,47	Bcl-2	38,43	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY Study|dep|ratio Study|nmod|relationship relationship|nmod|END_ENTITY	Study on the relationship between the Bcl-2 / Bax ratio and the growth types of leukemic cells and drug resistance in acute_myelogenous_leukemia .
10936684	0	Bax	43,46	Bcl-2	48,53	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Changes in apoptosis-related protein -LRB- p53 , Bax , Bcl-2 and Fos -RRB- expression with DNA fragmentation in the central nervous system in rats after closed_head_injury .
11041112	0	Bax	46,49	Bcl-2	22,27	Bax	Bcl-2	581	596	Gene	Gene	Heterodimerization|nmod|START_ENTITY Heterodimerization|nmod|END_ENTITY	Heterodimerization of Bcl-2 and Bcl-X -LRB- L -RRB- with Bax and Bad in colorectal_cancer .
11044365	0	Bax	6,9	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY predicts|nsubj|ratio END_ENTITY|parataxis|predicts	Bcl-2 / Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status .
11060313	0	Bax	85,88	Bcl-2	101,106	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|nmod|homology homology|compound|END_ENTITY	MAP-1 , a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains .
11205251	0	Bax	84,87	Bcl-2	34,39	Bax	Bcl-2	581	596	Gene	Gene	indices|compound|START_ENTITY correlation|nmod|indices expression|dep|correlation expression|nmod|protein protein|compound|END_ENTITY	Immunohistochemical expression of Bcl-2 protein in breast lesions : correlation with Bax , p53 , Rb , C-erbB-2 , EGFR and proliferation indices .
11245018	0	Bax	32,35	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	genes|dobj|START_ENTITY genes|nsubj|gene gene|amod|END_ENTITY	Bcl-2 gene and its family genes Bax , Bcl-Xl as well as Fas/Apo -1 and their clinical significance in acute_leukemia .
11259385	0	Bax	205,208	Bcl-2	199,204	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	A low-molecular-weight fraction of human seminal plasma activates adenylyl cyclase and induces caspase_3-independent apoptosis in prostatic epithelial cells by decreasing mitochondrial potential and Bcl-2 / Bax ratio .
11278245	0	Bax	75,78	Bcl-2	15,20	Bax	Bcl-2	581	596	Gene	Gene	binds|dobj|START_ENTITY member|acl:relcl|binds member|compound|END_ENTITY	Bcl-B , a novel Bcl-2 family member that differentially binds and regulates Bax and Bak .
11279112	0	Bax	15,18	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	oligomerization|compound|START_ENTITY prevents|dobj|oligomerization prevents|nsubj|END_ENTITY	Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane .
11410528	0	Bax	105,108	Bcl-2	41,46	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY induce|nmod|absence fail|xcomp|induce fail|nsubj|proteins proteins|dep|members members|compound|END_ENTITY	BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak .
11509139	0	Bax	96,99	Bcl-2	101,106	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|amod|END_ENTITY	-LSB- Modulation of angelica sinensis polysaccharides on the expression of nitric_oxide synthase and Bax , Bcl-2 in liver of immunological liver-injured mice -RSB- .
11694525	0	Bax	105,108	Bcl-2	99,104	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2 / Bax ratio in the p53 mutant pancreatic_cancer cell line MIA PaCa-2 .
11726273	0	Bax	16,19	Bcl-2	27,32	Bax	Bcl-2	581	596	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bax	16,19	Bcl-2	94,99	Bax	Bcl-2	581	596	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|parataxis|triggered triggered|nmod|phosphorylation phosphorylation|nmod|serine serine|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bax	33,36	Bcl-2	27,32	Bax	Bcl-2	581	596	Gene	Gene	heterodimer|compound|START_ENTITY triggered|nsubj|heterodimer Dissociation|parataxis|triggered Dissociation|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bax	33,36	Bcl-2	94,99	Bax	Bcl-2	581	596	Gene	Gene	heterodimer|compound|START_ENTITY triggered|nsubj|heterodimer triggered|nmod|phosphorylation phosphorylation|nmod|serine serine|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11768244	0	Bax	6,9	Bcl-2	0,5	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Bcl-2 / Bax protein expression in heart , slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions .
11839683	0	Bax	111,114	Bcl-2	83,88	Bax	Bcl-2	581	596	Gene	Gene	up-regulation|compound|START_ENTITY hyperphosphorylation|appos|up-regulation hyperphosphorylation|compound|END_ENTITY	Protein kinase A RIalpha antisense inhibition of PC3M_prostate_cancer cell growth : Bcl-2 hyperphosphorylation , Bax up-regulation , and Bad-hypophosphorylation .
11858462	0	Bax	24,27	Bcl-2	18,23	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY Alteration|dep|ratio Alteration|nmod|END_ENTITY	Alteration of the Bcl-2 : Bax ratio in the placenta as pregnancy proceeds .
11875499	0	Bax	125,128	Bcl-2	111,116	Bax	Bcl-2	581	596	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	Tumor-cell resistance to death receptor -- induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax .
11920608	0	Bax	143,146	Bcl-2	109,114	Bax	Bcl-2	581	596	Gene	Gene	status|compound|START_ENTITY correlated|nmod|status correlated|nmod|level level|nmod|END_ENTITY	Resistance of colon_cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X -LRB- L -RRB- in addition to Bax and p53 status .
11937734	0	Bax	84,87	Bcl-2	78,83	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Lymphocytes treated by extracorporeal photopheresis demonstrate a drop in the Bcl-2 / Bax ratio : a possible mechanism involved in extracorporeal-photopheresis-induced apoptosis .
11980885	0	Bax	0,3	Bcl-2	108,113	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	partner|nsubj|START_ENTITY partner|amod|necessary necessary|nmod|activity activity|nmod|END_ENTITY	Bax is not the heterodimerization partner necessary for sustained anti-photoreceptor-cell-death activity of Bcl-2 .
12170776	0	Bax	46,49	Bcl-2	116,121	Bax	Bcl-2	581	596	Gene	Gene	expressing|dobj|START_ENTITY adenovirus|acl|expressing induces|nsubj|adenovirus induces|dobj|apoptosis apoptosis|nmod|cells cells|nmod|status status|compound|END_ENTITY	A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate_cancer cells independently of their Bcl-2 status and androgen sensitivity .
12183413	0	Bax	175,178	Bcl-2	169,174	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis , as well as increased mitochondrial efficiency , superoxide dismutase activity , and Bcl-2 : Bax ratio .
12198774	0	Bax	42,45	Bcl-2	49,54	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Negative correlation between the ratio of Bax to Bcl-2 and the size of tumor treated by culture supernatants from Kupffer cells .
12477729	0	Bax	45,48	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins .
12490780	0	Bax	13,16	Bcl-2	88,93	Bax	Bcl-2	581	596	Gene	Gene	hyperexpressed|nsubjpass|START_ENTITY hyperexpressed|nmod|islets islets|nmod|END_ENTITY	Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2 .
12761582	0	Bax	24,27	Bcl-2	60,65	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY development|nmod|transgenic_mice inhibited|nsubjpass|development inhibited|nmod|END_ENTITY	Lymphoma development in Bax transgenic_mice is inhibited by Bcl-2 and associated with chromosomal instability .
12803975	0	Bax	33,36	Bcl-2	37,42	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	alterations|nmod|START_ENTITY alterations|dep|ratio ratio|compound|END_ENTITY	Temporal alterations in cellular Bax : Bcl-2 ratio following traumatic brain_injury in the rat .
12887767	0	Bax	58,61	Bcl-2	52,57	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	L|compound|START_ENTITY Expression|dep|L Expression|nmod|END_ENTITY	-LSB- Expression and function of apoptosis-related genes Bcl-2 / Bax and Fas/Fas _ L in the course of stress ulcer -RSB- .
12925958	0	Bax	75,78	Bcl-2	44,49	Bax	Bcl-2	581	596	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|NS5A NS5A|nmod|homologue homologue|compound|END_ENTITY	Hepatitis_C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular_carcinoma .
14531950	0	Bax	79,82	Bcl-2	88,93	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY hepatoma|dep|overexpression implanted|dobj|hepatoma implanted|nmod|END_ENTITY	Nimesulide inhibits tumor growth in mice implanted hepatoma : overexpression of Bax over Bcl-2 .
14572466	0	Bax	14,17	Bcl-2	69,74	Bax	Bcl-2	581	596	Gene	Gene	Regulation|nmod|START_ENTITY translocation|nsubj|Regulation translocation|nmod|Ser-70 Ser-70|nmod|END_ENTITY	Regulation of Bax translocation through phosphorylation at Ser-70 of Bcl-2 by MAP kinase in NO-induced neuronal apoptosis .
14672562	0	Bax	112,115	Bcl-2	106,111	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2 / Bax expression .
14681224	0	Bax	26,29	Bcl-2	45,50	Bax	Bcl-2	581	596	Gene	Gene	form|nmod|START_ENTITY behaves|nsubj|form behaves|nmod|protein protein|amod|END_ENTITY	The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein .
15030235	0	Bax	25,28	Bcl-2	19,24	Bax	Bcl-2	581	596	Gene	Gene	family|compound|START_ENTITY involved|nsubjpass|family Modulations|parataxis|involved Modulations|nmod|END_ENTITY	Modulations of the Bcl-2 / Bax family were involved in the chemopreventive effects of licorice root -LRB- Glycyrrhiza uralensis Fisch -RRB- in MCF-7 human breast_cancer cell .
15078907	0	Bax	0,3	Bcl-2	7,12	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Bax to Bcl-2 ratio and Ki-67 index are useful predictors of neoadjuvant chemoradiation therapy in bladder_cancer .
15132839	0	Bax	74,77	Bcl-2	68,73	Bax	Bcl-2	581	596	Gene	Gene	altering|dep|START_ENTITY altering|dobj|expression expression|nmod|END_ENTITY	Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2 / Bax and activating caspase-3 / ICAD pathway .
15159016	0	Bax	78,81	Bcl-2	72,77	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2 / Bax ratio .
15231068	0	Bax	27,30	Bcl-2	20,25	Bax	Bcl-2	581	596	Gene	Gene	partners|dep|START_ENTITY partners|nmod|END_ENTITY	Nuclear partners of Bcl-2 : Bax and PML .
15302859	0	Bax	157,160	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	capture|dobj|START_ENTITY provides|xcomp|capture arrangement|acl:relcl|provides surfaces|appos|arrangement involves|dobj|surfaces involves|nsubj|homodimerization homodimerization|amod|END_ENTITY	Bcl-2 homodimerization involves two distinct binding surfaces , a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax .
15302859	0	Bax	157,160	Bcl-2	130,135	Bax	Bcl-2	581	596	Gene	Gene	capture|dobj|START_ENTITY provides|xcomp|capture provides|dobj|mechanism mechanism|nmod|END_ENTITY	Bcl-2 homodimerization involves two distinct binding surfaces , a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax .
15467752	0	Bax	26,29	Bcl-2	12,17	Bax	Bcl-2	581	596	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL_and_5-FU through the mitochondrial apoptosis pathway .
15563666	0	Bax	120,123	Bcl-2	127,132	Bax	Bcl-2	581	596	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|ratio ratio|compound|END_ENTITY	MUC4 is increased in high grade intraepithelial_neoplasia in Barrett 's _ oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio .
15588281	0	Bax	106,109	Bcl-2	110,115	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax : Bcl-2 ratio and preventing proteolytic activities .
15661735	0	Bax	69,72	Bcl-2	63,68	Bax	Bcl-2	581	596	Gene	Gene	BimEL|compound|START_ENTITY BimEL|amod|END_ENTITY	Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2 / Bax family protein BimEL .
15703493	0	Bax	105,108	Bcl-2	112,117	Bax	Bcl-2	581	596	Gene	Gene	ratio|nmod|START_ENTITY upregulating|dobj|ratio upregulating|nmod|END_ENTITY	Bovine herpesvirus VP22 induces apoptosis in neuroblastoma cells by upregulating the expression ratio of Bax to Bcl-2 .
15714115	1	Bax	86,89	Bcl-2	80,85	Bax	Bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY study|dep|expression study|nmod|END_ENTITY	A study of Bcl-2 / Bax expression and keratinocyte rescue effects .
15807260	0	Bax	15,18	Bcl-2	20,25	Bax	Bcl-2	493837(Tax:9685)	493934(Tax:9685)	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	-LSB- Expression of Bax , Bcl-2 and caspase-3 in spared dorsal root ganglion after partial dorsal root rhizotomy -RSB- .
15881612	0	Bax	134,137	Bcl-2	128,133	Bax	Bcl-2	581	596	Gene	Gene	rheostat|compound|START_ENTITY rheostat|compound|END_ENTITY	Sphingosine_1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2 / Bax rheostat .
15923092	0	Bax	50,53	Bcl-2	44,49	Bax	Bcl-2	101842912	101833785	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Di - -LRB- 2-ethylhexyl -RRB- phthalate -LRB- DEHP -RRB- increases Bcl-2 / Bax ratio and modifies c-myc expression in Syrian_hamster embryo -LRB- SHE -RRB- cells .
15935058	0	Bax	98,101	Bcl-2	78,83	Bax	Bcl-2	581	596	Gene	Gene	applied|dobj|START_ENTITY applied|nmod|END_ENTITY	Fibroblast_growth_factor_2 applied to the optic nerve after axotomy increases Bcl-2 and decreases Bax in ganglion cells by activating the extracellular_signal-regulated_kinase signaling pathway .
15948248	0	Bax	133,136	Bcl-2	127,132	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Intravenous acid fibroblast growth factor protects intestinal mucosal cells against ischemia-reperfusion_injury via regulating Bcl-2 / Bax expression .
15960274	0	Bax	7,10	Bcl-2	1,6	Bax	Bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	-LSB- Bcl-2 / Bax gene expression in different types of carotid plaque -RSB- .
16009487	0	Bax	80,83	Bcl-2	16,21	Bax	Bcl-2	581	596	Gene	Gene	translocation|compound|START_ENTITY inhibition|nmod|translocation cisplatin-resistance|nmod|inhibition associated|nmod|cisplatin-resistance associated|nsubjpass|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder_cancer cells .
16023593	0	Bax	43,46	Bcl-2	37,42	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|dep|Killing Killing|advcl|flipping flipping|dobj|END_ENTITY	Killing cancer cells by flipping the Bcl-2 / Bax switch .
16132718	0	Bax	38,41	Bcl-2	45,50	Bax	Bcl-2	581	596	Gene	Gene	modifies|dobj|START_ENTITY modifies|xcomp|END_ENTITY	Overexpression of human GPX1 modifies Bax to Bcl-2 apoptotic ratio in human endothelial cells .
16188096	0	Bax	20,23	Bcl-2	13,18	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	-LSB- DNA damage , Bcl-2 , Bax expression and ultrastructure change in spermatogenic cell of mice exposed to cadmium -RSB- .
16243436	0	Bax	113,116	Bcl-2	107,112	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	dimmers|amod|START_ENTITY dimmers|dep|expression expression|appos|Bax Bax|nmod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16407825	0	Bax	0,3	Bcl-2	30,35	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|appos|members members|compound|END_ENTITY	Bax and Bid , two proapoptotic Bcl-2 family members , inhibit homologous recombination , independently of apoptosis regulation .
16510597	0	Bax	66,69	Bcl-2	43,48	Bax	Bcl-2	581	596	Gene	Gene	prevents|nmod|START_ENTITY prevents|dobj|interaction interaction|compound|END_ENTITY	The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant_glioma cells to induction of cell death .
16642033	0	Bax	38,41	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	oligomerization|compound|START_ENTITY inhibit|dobj|oligomerization conformation|xcomp|inhibit conformation|nsubj|changes changes|amod|END_ENTITY	Bcl-2 changes conformation to inhibit Bax oligomerization .
16721734	0	Bax	63,66	Bcl-2	70,75	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	extract|dobj|START_ENTITY extract|xcomp|END_ENTITY	Immunohistological evidences of Ginkgo_biloba extract altering Bax to Bcl-2 expression ratio in the hippocampus and motor cortex of senescence accelerated mice .
16888403	0	Bax	57,60	Bcl-2	51,56	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Inhalation of low-level formaldehyde increases the Bcl-2 / Bax expression ratio in the hippocampus of immunologically sensitized mice .
16906335	0	Bax	142,145	Bcl-2	136,141	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Diazoxide preconditioning alleviates apoptosis of hippocampal neurons induced by anoxia-reoxygenation in vitro through up-regulation of Bcl-2 / Bax protein ratio .
17005564	0	Bax	87,90	Bcl-2	59,64	Bax	Bcl-2	581	596	Gene	Gene	formation|compound|START_ENTITY inhibits|dobj|formation elicits|dep|inhibits elicits|dobj|alteration alteration|nmod|END_ENTITY	tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation .
17053028	0	Bax	94,97	Bcl-2	88,93	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	rate|compound|START_ENTITY inhibiting|dep|rate inhibiting|nmod|apoptosis apoptosis|nmod|END_ENTITY	Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2 / Bax rate and p38-beta mitogen-activated protein kinase .
17076657	0	Bax	136,139	Bcl-2	130,135	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|nummod|END_ENTITY	Recombinant human granulocyte_colony-stimulating_factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2 / Bax expression levels .
17081372	0	Bax	87,90	Bcl-2	81,86	Bax	Bcl-2	581	596	Gene	Gene	changes|compound|START_ENTITY -RSB-|nsubj|changes C-reactive_protein|parataxis|-RSB- C-reactive_protein|acl|induced induced|dobj|cells cells|acl:relcl|associated associated|nmod|END_ENTITY	-LSB- C-reactive_protein induced human endothelium cells apoptosis is associated with Bcl-2 / Bax gene expression changes -RSB- .
17331788	0	Bax	45,48	Bcl-2	173,178	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|apoptosis apoptosis|acl|induced induced|nmod|suberoylanilide_hydroxamic_acid suberoylanilide_hydroxamic_acid|nmod|expression expression|dep|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
17369104	0	Bax	126,129	Bcl-2	120,125	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	D-beta-hydroxybutyrate inhibits the apoptosis of PC12 cells induced by 6-OHDA in relation to up-regulating the ratio of Bcl-2 / Bax mRNA .
17386268	0	Bax	92,95	Bcl-2	40,45	Bax	Bcl-2	581	596	Gene	Gene	role|nmod|START_ENTITY mimic|dep|role mimic|nmod|END_ENTITY	A structural viral mimic of prosurvival Bcl-2 : a pivotal role for sequestering proapoptotic Bax and Bak .
17408077	0	Bax	6,9	Bcl-2	0,5	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Bcl-2 / Bax ratio , mitochondrial membranes and aerobic enzyme activity in cardiomyocytes of rats after submaximal training .
17431754	0	Bax	11,14	Bcl-2	5,10	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY protects|nsubj|ratio END_ENTITY|parataxis|protects	High Bcl-2 / Bax ratio in Walker_tumor cells protects mitochondria but does not prevent H2O2-induced apoptosis via calcineurin pathways .
17577309	0	Bax	108,111	Bcl-2	102,107	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Matrine induces apoptosis in angiotensin_II-stimulated hyperplasia of cardiac fibroblasts : effects on Bcl-2 / Bax expression and caspase-3 activation .
17577445	0	Bax	94,97	Bcl-2	87,92	Bax	Bcl-2	581	596	Gene	Gene	protein|compound|START_ENTITY Effects|appos|protein Effects|nmod|END_ENTITY	-LSB- Effects of nerve_growth_factor pretreatment on apoptosis of neurons and expression of Bcl-2 , Bax protein in brain tissue following cerebral_ischemia / reperfusion injury in gerbils -RSB- .
17639989	0	Bax	98,101	Bcl-2	108,113	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|level level|compound|END_ENTITY	-LSB- Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA , Bcl-2 mRNA level in brain of rat with Alzheimer 's _ disease -RSB- .
17880809	0	Bax	41,44	Bcl-2	70,75	Bax	Bcl-2	581	596	Gene	Gene	proapoptotic|dep|START_ENTITY proteins|amod|proapoptotic proteins|appos|END_ENTITY	-LSB- Analysis of intracellular proapoptotic -LRB- Bax , Bak -RRB- and antiapoptotic -LRB- Bcl-2 , Bcl-XL -RRB- proteins expression in thyrocytes from young patients with immune and non-immune thyroid_disorders -RSB- .
18178565	0	Bax	27,30	Bcl-2	57,62	Bax	Bcl-2	581	596	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|proteins proteins|compound|END_ENTITY	Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1 .
18604733	0	Bax	54,57	Bcl-2	47,52	Bax	Bcl-2	581	596	Gene	Gene	p53|dep|START_ENTITY p53|compound|END_ENTITY	Apoptosis and proliferation related molecules -LRB- Bcl-2 , Bax , p53 , PCNA -RRB- in papillary_microcarcinoma versus papillary_carcinoma of the thyroid .
18620728	0	Bax	113,116	Bcl-2	107,112	Bax	Bcl-2	581	596	Gene	Gene	balance|nsubj|START_ENTITY balance|parataxis|participates participates|advcl|affecting affecting|dobj|END_ENTITY	Deleted_in_pancreatic_carcinoma_locus_4 / Smad4 participates in the regulation of apoptosis by affecting the Bcl-2 / Bax balance in non-small cell lung_cancer .
18692524	0	Bax	90,93	Bcl-2	84,89	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	CXCL12/CXCR4 signaling promotes human thymic dendritic cell survival regulating the Bcl-2 / Bax ratio .
18981409	0	Bax	71,74	Bcl-2	40,45	Bax	Bcl-2	581	596	Gene	Gene	restrain|dobj|START_ENTITY restrain|nsubj|proteins proteins|compound|END_ENTITY	Apoptosis is triggered when prosurvival Bcl-2 proteins can not restrain Bax .
19086645	0	Bax	112,115	Bcl-2	106,111	Bax	Bcl-2	581	596	Gene	Gene	-RSB-|compound|START_ENTITY induces|nsubj|-RSB- induces|advcl|regulating regulating|dobj|/ /|compound|END_ENTITY	-LSB- Curcumin inhibits growth , induces G1_arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2 / Bax -RSB- .
19360319	0	Bax	37,40	Bcl-2	42,47	Bax	Bcl-2	581	596	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
19424680	0	Bax	126,129	Bcl-2	119,124	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Safflor_yellow_B suppresses pheochromocytoma cell -LRB- PC12 -RRB- injury induced by oxidative stress via antioxidant system and Bcl-2 / Bax pathway .
19813621	0	Bax	4,7	Bcl-2	59,64	Bax	Bcl-2	581	596	Gene	Gene	H2-H3|compound|START_ENTITY promotes|nsubj|H2-H3 promotes|advcl|inhibiting inhibiting|dobj|pore-forming pore-forming|nmod:npmod|END_ENTITY	The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2 's pore-forming and anti-Bax activities in the membrane .
19941892	0	Bax	102,105	Bcl-2	107,112	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax , Bcl-2 expression .
20148304	0	Bax	49,52	Bcl-2	72,77	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Effect of chronic lead exposure on pro-apoptotic Bax and anti-apoptotic Bcl-2 protein expression in rat hippocampus in vivo .
20948210	0	Bax	108,111	Bcl-2	102,107	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Antitumor effects of ginkgolic_acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2 / Bax ratio to induce apoptosis .
21060756	0	Bax	157,160	Bcl-2	151,156	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|/ /|amod|END_ENTITY	Time dependent bladder apoptosis induced by acute bladder_outlet_obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2 / Bax ratio .
21073944	0	Bax	175,178	Bcl-2	213,218	Bax	Bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Progallin_A isolated from the acetic ether part of the leaves of Phyllanthus emblica L. induces apoptosis of human hepatocellular_carcinoma BEL-7404 cells by up-regulation of Bax expression and down-regulation of Bcl-2 expression .
21115120	0	Bax	95,98	Bcl-2	89,94	Bax	Bcl-2	581	596	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|compound|END_ENTITY	Selective impairment of CD4 + CD25 + Foxp3 + regulatory T cells by paclitaxel is explained by Bcl-2 / Bax mediated apoptosis .
21148306	0	Bax	105,108	Bcl-2	54,59	Bax	Bcl-2	581	596	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X -LRB- L -RRB- , Bcl-2 , and MCL-1 protein-protein interactions with Bax , Bak , Bad , or Bim and induces apoptosis in a Bax - and Bim-dependent manner .
21158042	0	Bax	52,55	Bcl-2	45,50	Bax	Bcl-2	581	596	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|Rb1 Rb1|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of Rb1 and Rg1 on the expression of Bcl-2 , Bax in apoptosis of HK-2 cells induced by the serum of kidney_ischemia / reperfusion -RSB- .
21242808	0	Bax	96,99	Bcl-2	103,108	EPO	Bcl-2	2056	596	Gene	Gene	ratio|nmod|START_ENTITY reduces|dobj|ratio reduces|nmod|proteins proteins|compound|END_ENTITY	Recombinant human erythropoietin suppresses endothelial cell apoptosis and reduces the ratio of Bax to Bcl-2 proteins in the aortas of apolipoprotein_E-deficient mice .
21472231	0	Bax	149,152	Bcl-2	116,121	Bax	Bcl-2	581	596	Gene	Gene	Bak|dep|START_ENTITY apoptotic|appos|Bak apoptotic|dep|Immunoexpression Immunoexpression|nmod|family family|compound|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21472231	0	Bax	149,152	Bcl-2	130,135	Bax	Bcl-2	581	596	Gene	Gene	Bak|dep|START_ENTITY Bak|compound|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21485723	0	Bax	35,38	Bcl-2	28,33	Bax	Bcl-2	581	596	Gene	Gene	caspase-3|dep|START_ENTITY caspase-3|compound|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
21545224	0	Bax	144,147	Bcl-2	138,143	Bax	Bcl-2	581	596	Gene	Gene	effects|dep|START_ENTITY effects|dep|role role|nmod|END_ENTITY	Anti-proliferative effects of organic extracts from root bark of Juglans Regia L. -LRB- RBJR -RRB- on MDA-MB-231 human breast_cancer cells : role of Bcl-2 / Bax , caspases and Tp53 .
21783889	0	Bax	92,95	Bcl-2	86,91	Bax	Bcl-2	581	596	Gene	Gene	regulation|compound|START_ENTITY regulation|amod|END_ENTITY	Propolis induces cell cycle arrest and apoptosis in human leukemic U937 cells through Bcl-2 / Bax regulation .
21894749	0	Bax	25,28	Bcl-2	18,23	Bax	Bcl-2	581	596	Gene	Gene	p53|dep|START_ENTITY p53|compound|END_ENTITY	-LSB- Dynamic study of Bcl-2 , Bax , p53 , and ACE expression in CD34 + cells of peripheral blood and bone marrow in acute_leukemia patients in the course of induction chemotherapy -RSB- .
21935568	0	Bax	123,126	Bcl-2	117,122	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	The potent peptide antagonist to angiogenesis , C16Y , and cisplatin act synergistically in the down-regulation of the Bcl-2 / Bax ratio and the induction of apoptosis in human ovarian_cancer cells .
22013032	0	Bax	65,68	Bcl-2	27,32	Bax	Bcl-2	581	596	Gene	Gene	inhibitors|compound|START_ENTITY act|nmod|inhibitors act|nsubj|homologues homologues|compound|END_ENTITY	The vaccinia_virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors .
22886241	0	Bax	36,39	Bcl-2	30,35	Bax	Bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY affects|nsubj|expression regulation|parataxis|affects regulation|nmod|END_ENTITY	AP-2a-dependent regulation of Bcl-2 / Bax expression affects apoptosis in the trophoblast .
22917577	0	Bax	142,145	Bcl-2	116,121	Bax	Bcl-2	581	596	Gene	Gene	apoptosis|nmod|START_ENTITY apoptosis|nmod|cells cells|nmod|up-regulation up-regulation|nmod|END_ENTITY	Resistance to butyrate impairs bile_acid-induced apoptosis in human colon_adenocarcinoma cells via up-regulation of Bcl-2 and inactivation of Bax .
22926545	0	Bax	56,59	Bcl-2	50,55	Bax	Bcl-2	581	596	Gene	Gene	apoptosis|dep|START_ENTITY apoptosis|nmod|down-regulation down-regulation|nmod|END_ENTITY	Daidzein induced apoptosis via down-regulation of Bcl-2 / Bax and triggering of the mitochondrial pathway in BGC-823 cells .
23023341	0	Bax	98,101	Bcl-2	92,97	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	signal|nsubj|START_ENTITY effect|parataxis|signal effect|nmod|neurotoxicity neurotoxicity|nmod|cells cells|nmod|END_ENTITY	Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2 / Bax signal pathway .
23064052	0	Bax	14,17	Bcl-2	48,53	Bax	Bcl-2	581	596	Gene	Gene	Regulation|nmod|START_ENTITY mitochondrial|nsubj|Regulation mitochondrial|nmod|END_ENTITY	Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x -LRB- L -RRB- : keep your friends close but your enemies closer .
23108993	0	Bax	80,83	Bcl-2	85,90	Bax	Bcl-2	100355675(Tax:9986)	100009447(Tax:9986)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
23154865	0	Bax	31,34	Bcl-2	38,43	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|nmod|mutants mutants|compound|END_ENTITY	Enhanced heterodimerization of Bax by Bcl-2 mutants improves irradiated cell survival .
23245210	0	Bax	115,118	Bcl-2	109,114	Bax	Bcl-2	581	596	Gene	Gene	balance|compound|START_ENTITY balance|amod|END_ENTITY	Melatonin is involved in the apoptosis and necrosis of pancreatic_cancer cell line SW-1990 via modulating of Bcl-2 / Bax balance .
23297497	0	Bax	115,118	Bcl-2	109,114	Bax	Bcl-2	581	596	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Downregulation of PAR expression induces the apoptosis of human prostate_cancer PC3 cells and increases the Bcl-2 / Bax ratio -RSB- .
23365696	0	Bax	82,85	Bcl-2	76,81	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Exhaustive training increases uncoupling_protein_2 expression and decreases Bcl-2 / Bax ratio in rat skeletal muscle .
23451794	0	Bax	131,134	Bcl-2	125,130	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Flavanols from evening primrose -LRB- Oenothera paradoxa -RRB- defatted seeds inhibit prostate cells invasiveness and cause changes in Bcl-2 / Bax mRNA ratio .
23527236	0	Bax	24,27	Bcl-2	18,23	Bax	Bcl-2	581	596	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|dep|Apoptosis Apoptosis|dep|END_ENTITY	Apoptosis through Bcl-2 / Bax and cleaved caspase up-regulation in melanoma treated by boron neutron capture therapy .
23563626	0	Bax	94,97	Bcl-2	88,93	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Hydrogen-rich medium suppresses the generation of reactive oxygen species , elevates the Bcl-2 / Bax ratio and inhibits advanced glycation end product-induced apoptosis .
23626686	0	Bax	157,160	Bcl-2	37,42	Bax	Bcl-2	581	596	Gene	Gene	protein|compound|START_ENTITY Reconstitution|nmod|protein Reconstitution|nmod|protein protein|compound|END_ENTITY	Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein .
23631820	0	Bax	144,147	Bcl-2	138,143	Bax	Bcl-2	581	596	Gene	Gene	balance|compound|START_ENTITY balance|amod|END_ENTITY	Annexin_A3 is associated with a poor prognosis in breast_cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2 / Bax balance .
23710741	12	Bax	2423,2426	Bcl-2	2417,2422	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	B|dep|START_ENTITY END_ENTITY|dep|B	Bax , Bcl-2 expression and apoptosis index of group B , C and D were significantly higher than that of group A -LRB- all P < 0.05 -RRB- , while Bcl-2 / Bax of group B , C and D were significantly lower than that of group A -LRB- all P < 0.05 -RRB- .
23991130	0	Bax	158,161	Bcl-2	152,157	Bax	Bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MicroRNA-650 was a prognostic factor in human lung_adenocarcinoma and confers the docetaxel chemoresistance of lung_adenocarcinoma cells via regulating Bcl-2 / Bax expression .
24095822	0	Bax	121,124	Bcl-2	115,120	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor_impairment , redox balance and Bcl-2 / Bax expression in experimental Parkinson 's _ disease mice .
24633814	0	Bax	82,85	Bcl-2	76,81	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|apoptosis apoptosis|nmod|cells cells|nmod|modulation modulation|nmod|END_ENTITY	Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2 / Bax and caspase-3 activation .
24677263	0	Bax	67,70	Bcl-2	61,66	Bax	Bcl-2	581	596	Gene	Gene	proteins|compound|START_ENTITY proteins|nummod|END_ENTITY	CDK1 switches mitotic_arrest to apoptosis by phosphorylating Bcl-2 / Bax family proteins during treatment with microtubule interfering agents .
24690773	0	Bax	130,133	Bcl-2	101,106	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	An-Gong-Niu-Huang Wan protects against cerebral_ischemia induced apoptosis in rats : up-regulation of Bcl-2 and down-regulation of Bax and caspase-3 .
24818492	0	Bax	114,117	Bcl-2	107,112	Bax	Bcl-2	100355675(Tax:9986)	100009447(Tax:9986)	Gene	Gene	Caspase-3|amod|START_ENTITY Caspase-3|amod|END_ENTITY	-LSB- Effects of acupotomy , electroacupuncture or round-sharp acupuncture needle interventions on expression of Bcl-2 , Bax , Caspase-3 proteins of rectus femoris in rabbits with knee ostarthritis -RSB- .
24819963	0	Bax	53,56	Bcl-2	58,63	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
24880241	0	Bax	6,9	Bcl-2	0,5	Bax	Bcl-2	101842912	101833785	Gene	Gene	Tend|compound|START_ENTITY END_ENTITY|dep|Tend	Bcl-2 / Bax Expression Levels Tend to Influence AMPAergic Trafficking Mechanisms During Hibernation in Mesocricetus_auratus .
24912196	0	Bax	81,84	Bcl-2	12,17	Bax	Bcl-2	581	596	Gene	Gene	inhibiting|dobj|START_ENTITY affect|advcl|inhibiting affect|nsubj|members members|compound|END_ENTITY	Prosurvival Bcl-2 family members affect autophagy only indirectly , by inhibiting Bax and Bak .
25108507	0	Bax	117,120	Bcl-2	111,116	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Significance of apoptosis related proteins on malignant transformation of ovarian_tumors : A comparison between Bcl-2 / Bax ratio and p53 immunoreactivity .
25187829	0	Bax	90,93	Bcl-2	84,89	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Emodin inhibits LOVO colorectal_cancer cell proliferation via the regulation of the Bcl-2 / Bax ratio and cytochrome_c .
25374178	0	Bax	19,22	Bcl-2	13,18	Bax	Bcl-2	581	596	Gene	Gene	Roles|dep|START_ENTITY Roles|nmod|END_ENTITY	Roles of the Bcl-2 / Bax ratio , caspase-8 and 9 in resistance of breast_cancer cells to paclitaxel .
25471003	0	Bax	77,80	Bcl-2	70,75	Bax	Bcl-2	581	596	Gene	Gene	survivin|dep|START_ENTITY survivin|compound|END_ENTITY	Changes in the expression pattern of apoptotic molecules -LRB- galectin-3 , Bcl-2 , Bax , survivin -RRB- during progression of thyroid_malignancy and their clinical significance .
25489228	0	Bax	99,102	Bcl-2	93,98	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	increasing|dobj|START_ENTITY increasing|iobj|END_ENTITY	Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2 / Bax and Bcl-xL/Bax ratios and reducing reactive gliosis .
25556484	0	Bax	105,108	Bcl-2	145,150	Bax	Bcl-2	581	596	Gene	Gene	Apoptosis|nmod|START_ENTITY Apoptosis|dep|FasL FasL|nmod|END_ENTITY	b-elemene Induces Caspase-dependent Apoptosis in Human_Glioma Cells in vitro through the Upregulation of Bax and Fas / FasL and Downregulation of Bcl-2 .
25582208	0	Bax	40,43	Bcl-2	34,39	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Effect|dep|expression Effect|nmod|END_ENTITY	-LSB- Effect of simvastatin on retinal Bcl-2 / Bax expression and cell apoptosis in rats with ischemia-reperfusion injury -RSB- .
25775423	0	Bax	108,111	Bcl-2	102,107	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Acetylated Chitosan Oligosaccharides Act as Antagonists against Glutamate-Induced PC12 Cell Death via Bcl-2 / Bax Signal Pathway .
25857445	0	Bax	50,53	Bcl-2	54,59	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	MicroRNA-29a induces apoptosis via increasing the Bax : Bcl-2 ratio in dermal fibroblasts of patients with systemic_sclerosis .
25867342	0	Bax	53,56	Bcl-2	47,52	Bax	Bcl-2	581	596	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of TIEG1 on apoptosis and expression of Bcl-2 / Bax and Pten in leukemic cell lines .
25975837	0	Bax	112,115	Bcl-2	121,126	Bax	Bcl-2	581	596	Gene	Gene	upregulation|nmod|START_ENTITY bortezomib|nmod|upregulation bortezomib|nmod|END_ENTITY	ALK-negative anaplastic_large_cell_lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2 .
26281601	0	Bax	66,69	Bcl-2	60,65	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY subcutaneous|nsubj|expression Effects|parataxis|subcutaneous Effects|nmod|cisplatin cisplatin|nmod|END_ENTITY	-LSB- Effects of compound Daqiqi decoction combined cisplatin on Bcl-2 / Bax expression of nude_mice ovarian_cancer subcutaneous transplanted_tumor -RSB- .
26281601	0	Bax	66,69	Bcl-2	60,65	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY subcutaneous|nsubj|expression Effects|parataxis|subcutaneous Effects|nmod|cisplatin cisplatin|nmod|END_ENTITY	-LSB- Effects of compound Daqiqi decoction combined cisplatin on Bcl-2 / Bax expression of nude_mice ovarian_cancer subcutaneous transplanted_tumor -RSB- .
26387182	0	Bax	43,46	Bcl-2	37,42	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	START_ENTITY|dep|-LSB- -LSB-|dobj|alterations alterations|nmod|END_ENTITY	-LSB- The alterations of apoptosis factor Bcl-2 / Bax in the early Parkinson 's _ disease rats and the protective effect of scorpion venom derived activity peptide -RSB- .
26387182	0	Bax	43,46	Bcl-2	37,42	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	START_ENTITY|dep|-LSB- -LSB-|dobj|alterations alterations|nmod|END_ENTITY	-LSB- The alterations of apoptosis factor Bcl-2 / Bax in the early Parkinson 's _ disease rats and the protective effect of scorpion venom derived activity peptide -RSB- .
26491047	0	Bax	72,75	Bcl-2	66,71	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	ATP promotes cell survival via regulation of cytosolic -LSB- Ca2 + -RSB- and Bcl-2 / Bax ratio in lung_cancer cells .
26679980	0	Bax	101,104	Bcl-2	72,77	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	Caspase-3|dep|START_ENTITY Caspase-3|amod|END_ENTITY	Subchronic exposure of benzo -LRB- a -RRB- pyrene interferes with the expression of Bcl-2 , Ki-67 , C-myc and p53 , Bax , Caspase-3 in sub-regions of cerebral cortex and hippocampus .
26813281	0	Bax	79,82	Bcl-2	73,78	Bax	Bcl-2	581	596	Gene	Gene	-RSB-|nsubj|START_ENTITY Effects|parataxis|-RSB- Effects|nmod|END_ENTITY	-LSB- Effects of emodin-8-O-b-D-glucoside on cell apoptosis and expression of Bcl-2 / Bax in cervical cancer SKOV3 cells -RSB- .
26900785	0	Bax	50,53	Bcl-2	44,49	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	balance|compound|START_ENTITY END_ENTITY|dep|balance	Lycopene modulates cholinergic dysfunction , Bcl-2 / Bax balance , and antioxidant enzymes gene transcripts in monosodium_glutamate -LRB- E621 -RRB- induced neurotoxicity in a rat model .
26939764	0	Bax	119,122	Bcl-2	113,118	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Dietary restriction suppresses apoptotic cell death , promotes Bcl-2 and Bcl-xl mRNA expression and increases the Bcl-2 / Bax protein ratio in the rat cortex after cortical_injury .
27053609	0	Bax	19,22	Bcl-2	60,65	Bax	Bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	caspase-3|dep|START_ENTITY caspase-3|nmod|END_ENTITY	-LSB- Up-regulations of Bax and caspase-3 and down-regulation of Bcl-2 after Xinfeng capsule treatment in adjuvant-induced_arthritis rats -RSB- .
7644501	0	Bax	71,74	Bcl-2	9,14	Bax	Bcl-2	581	596	Gene	Gene	demonstrate|nmod|START_ENTITY demonstrate|nsubj|members members|compound|END_ENTITY	Multiple Bcl-2 family members demonstrate selective dimerizations with Bax .
7992838	0	Bax	61,64	Bcl-2	90,95	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY determination|nmod|distribution determination|appos|inhibitor inhibitor|nmod|END_ENTITY	Immunohistochemical determination of in vivo distribution of Bax , a dominant inhibitor of Bcl-2 .
8183370	0	Bax	98,101	Bcl-2	23,28	Bax	Bcl-2	581	596	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|domains domains|nmod|END_ENTITY	BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax .
8358790	0	Bax	56,59	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	homolog|appos|START_ENTITY heterodimerizes|nmod|homolog heterodimerizes|nsubj|END_ENTITY	Bcl-2 heterodimerizes in vivo with a conserved homolog , Bax , that accelerates programmed cell death .
8621473	0	Bax	24,27	Bcl-2	42,47	Bax	Bcl-2	581	596	Gene	Gene	START_ENTITY|acl:relcl|converts converts|dobj|END_ENTITY	A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis .
8631771	0	Bax	21,24	Bcl-2	46,51	Bax	Bcl-2	581	596	Gene	Gene	heterodimerizes|nsubj|START_ENTITY heterodimerizes|nmod|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
8631771	0	Bax	75,78	Bcl-2	46,51	Bax	Bcl-2	581	596	Gene	Gene	heterodimerizes|nmod|START_ENTITY heterodimerizes|nmod|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
8777167	0	Bax	14,17	Bcl-2	33,38	Bax	Bcl-2	581	596	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|relation relation|nmod|END_ENTITY	Expression of Bax in relation to Bcl-2 and other predictive parameters in breast_cancer .
9058596	0	Bax	37,40	Bcl-2	31,36	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|dep|decreases decreases|dobj|END_ENTITY	6-Mercaptopurine decreases the Bcl-2 / Bax ratio and induces apoptosis in activated splenic B lymphocytes .
9108402	0	Bax	33,36	Bcl-2	27,32	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	CD6 ligation modulates the Bcl-2 / Bax ratio and protects chronic_lymphocytic_leukemia B cells from apoptosis induced by anti-IgM .
9202007	0	Bax	73,76	Bcl-2	57,62	Bax	Bcl-2	581	596	Gene	Gene	truncation|compound|START_ENTITY mutant|nmod|truncation mutant|nsubj|complementation complementation|nmod|END_ENTITY	Structural and functional complementation of an inactive Bcl-2 mutant by Bax truncation .
9219694	0	Bax	14,17	Bcl-2	46,51	Bax	Bcl-2	581	596	Gene	Gene	Inhibition|nmod|START_ENTITY channel-forming|nsubj|Inhibition channel-forming|nmod|END_ENTITY	Inhibition of Bax channel-forming activity by Bcl-2 .
9361016	0	Bax	28,31	Bcl-2	0,5	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	heterodimerization-dependent|compound|START_ENTITY apoptosis|nmod|heterodimerization-dependent apoptosis|nsubj|counters counters|amod|END_ENTITY	Bcl-2 counters apoptosis by Bax heterodimerization-dependent and - independent mechanisms in the T-cell lineage .
9362442	0	Bax	54,57	Bcl-2	98,103	Bax	Bcl-2	581	596	Gene	Gene	overexpression|compound|START_ENTITY induced|nmod|overexpression cells|acl|induced apoptosis|nmod|cells apoptosis|dep|effects effects|nmod|END_ENTITY	Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression : differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis .
9389564	0	Bax	14,17	Bcl-2	49,54	Bax	Bcl-2	581	596	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|member member|nmod|family family|compound|END_ENTITY	Expression of Bax , a pro-apoptotic member of the Bcl-2 family , in esophageal_squamous_cell_carcinoma .
9432028	0	Bax	21,24	Bcl-2	15,20	Bax	Bcl-2	581	596	Gene	Gene	levels|compound|START_ENTITY levels|dep|Alterations Alterations|dep|END_ENTITY	Alterations in Bcl-2 / Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis .
9517506	0	Bax	15,18	Bcl-2	9,14	Bax	Bcl-2	581	596	Gene	Gene	feature|nsubj|START_ENTITY END_ENTITY|parataxis|feature	Elevated Bcl-2 / Bax are a consistent feature of apoptosis resistance in B-cell_chronic_lymphocytic_leukaemia and are correlated with in vivo chemoresistance .
9610364	0	Bax	102,105	Bcl-2	96,101	Bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Zinc suppresses apoptosis of U937 cells induced by hydrogen_peroxide through an increase of the Bcl-2 / Bax ratio .
9695020	1	Bax	44,47	Bcl-2	23,28	Bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	The pro-apoptotic Bcl-2 family member , Bax .
9714690	0	Bax	106,109	Bcl-2	0,5	Bax	Bcl-2	581	596	Gene	Gene	involvement|nmod|START_ENTITY expression|dep|involvement expression|amod|END_ENTITY	Bcl-2 family expression in salivary glands from patients with primary Sj gren 's _ syndrome : involvement of Bax in salivary gland destruction .
9802058	0	Bax	0,3	Bcl-2	97,102	Bax	Bcl-2	581	596	Gene	Gene	determinant|nsubj|START_ENTITY determinant|nmod|status status|amod|independent independent|nmod|expression expression|compound|END_ENTITY	Bax is an important determinant of chemosensitivity in pediatric_tumor cell lines independent of Bcl-2 expression and p53 status .
9885381	0	Bax	39,42	Bcl-2	32,37	Bax	Bcl-2	581	596	Gene	Gene	Bcl-X|dep|START_ENTITY Bcl-X|compound|END_ENTITY	Immunohistochemical analysis of Bcl-2 , Bax , Bcl-X , and Mcl-1 expression in pancreatic_cancers .
11278245	0	Bax	75,78	Bcl-B	0,5	Bax	Bcl-B	581	10017	Gene	Gene	binds|dobj|START_ENTITY member|acl:relcl|binds END_ENTITY|appos|member	Bcl-B , a novel Bcl-2 family member that differentially binds and regulates Bax and Bak .
18178565	0	Bax	27,30	Bcl-B	79,84	Bax	Bcl-B	581	10017	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1 .
10049709	0	Bax	56,59	Bcl-XL	91,97	Bax	Bcl-XL	581	598	Gene	Gene	state|nmod|START_ENTITY characterization|nmod|state characterization|nmod|END_ENTITY	Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl-XL .
12198137	0	Bax	113,116	Bcl-XL	0,6	Bax	Bcl-XL	581	598	Gene	Gene	interacting|nmod|START_ENTITY change|acl|interacting protects|dobj|change protects|nsubj|END_ENTITY	Bcl-XL protects BimEL-induced Bax conformational change and cytochrome_C release independent of interacting with Bax or BimEL .
12198137	0	Bax	30,33	Bcl-XL	0,6	Bax	Bcl-XL	581	598	Gene	Gene	conformational|amod|START_ENTITY change|amod|conformational protects|dobj|change protects|nsubj|END_ENTITY	Bcl-XL protects BimEL-induced Bax conformational change and cytochrome_C release independent of interacting with Bax or BimEL .
15698865	0	Bax	12,15	Bcl-XL	17,23	Bax	Bcl-XL	581	598	Gene	Gene	Increase|nmod|START_ENTITY Increase|dep|ratio ratio|compound|END_ENTITY	Increase of Bax / Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line .
16061221	0	Bax	43,46	Bcl-XL	20,26	Bax	Bcl-XL	581	598	Gene	Gene	antagonism|amod|START_ENTITY involved|nmod|antagonism involved|nsubjpass|domains domains|nmod|END_ENTITY	Distinct domains of Bcl-XL are involved in Bax and Bad antagonism and in apoptosis inhibition .
17880809	0	Bax	41,44	Bcl-XL	77,83	Bax	Bcl-XL	581	598	Gene	Gene	proapoptotic|dep|START_ENTITY proteins|amod|proapoptotic proteins|appos|Bcl-2 Bcl-2|dep|END_ENTITY	-LSB- Analysis of intracellular proapoptotic -LRB- Bax , Bak -RRB- and antiapoptotic -LRB- Bcl-2 , Bcl-XL -RRB- proteins expression in thyrocytes from young patients with immune and non-immune thyroid_disorders -RSB- .
18547146	0	Bax	60,63	Bcl-XL	0,6	Bax	Bcl-XL	581	598	Gene	Gene	competing|nmod|START_ENTITY inhibits|advcl|competing inhibits|nsubj|END_ENTITY	Bcl-XL inhibits membrane permeabilization by competing with Bax .
22892098	0	Bax	54,57	Bcl-XL	77,83	Bax	Bcl-XL	581	598	Gene	Gene	dissociating|dobj|START_ENTITY dissociating|nmod|END_ENTITY	L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL .
7834748	0	Bax	61,64	Bcl-XL	33,39	Bax	Bcl-XL	581	598	Gene	Gene	displaces|dobj|START_ENTITY displaces|nsubj|Bad Bad|appos|partner partner|nmod|END_ENTITY	Bad , a heterodimeric partner for Bcl-XL and Bcl-2 , displaces Bax and promotes cell death .
8798452	0	Bax	0,3	Bcl-XL	121,127	Bax	Bcl-XL	581	598	Gene	Gene	antagonize|nsubj|START_ENTITY antagonize|nmod|death death|nmod|heterodimerization heterodimerization|nmod|END_ENTITY	Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL .
8798452	0	Bax	0,3	Bcl-XL	19,25	Bax	Bcl-XL	581	598	Gene	Gene	antagonize|nsubj|START_ENTITY antagonize|dobj|END_ENTITY	Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL .
15782132	0	Bax	66,69	Bcl-xL	72,78	Bax	Bcl-xL	581	598	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity .
15983241	0	Bax	30,33	Bcl-xL	0,6	Bax	Bcl-xL	24887(Tax:10116)	24888(Tax:10116)	Gene	Gene	translocation|compound|START_ENTITY inhibits|dobj|translocation inhibits|nsubj|transfer transfer|compound|END_ENTITY	Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rats .
17331788	0	Bax	45,48	Bcl-xL	179,185	Bax	Bcl-xL	24887(Tax:10116)	24888(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|apoptosis apoptosis|acl|induced induced|nmod|suberoylanilide_hydroxamic_acid suberoylanilide_hydroxamic_acid|nmod|expression expression|amod|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
17519046	0	Bax	73,76	Bcl-xL	143,149	Bax	Bcl-xL	581	598	Gene	Gene	helices|nmod|START_ENTITY N-terminus|appos|helices modulate|nsubj|N-terminus modulate|nmod|END_ENTITY	The N-terminus and alpha-5 , alpha-6 helices of the pro-apoptotic protein Bax , modulate functional interactions with the anti-apoptotic protein Bcl-xL .
18636161	0	Bax	62,65	Bcl-xL	34,40	Bax	Bcl-xL	581	598	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
18698495	0	Bax	68,71	Bcl-xL	75,81	Bax	Bcl-xL	581	598	Gene	Gene	START_ENTITY|nmod|ratios ratios|amod|END_ENTITY	Tanshinone_IIA inhibits human breast_cancer cells through increased Bax to Bcl-xL ratios .
19427863	0	Bax	44,47	Bcl-xL	26,32	Bax	Bcl-xL	581	598	Gene	Gene	activation|compound|START_ENTITY promote|dobj|activation neutralizes|xcomp|promote neutralizes|dobj|END_ENTITY	BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis .
23954445	0	Bax	70,73	Bcl-xL	27,33	Bax	Bcl-xL	581	598	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|knock-down knock-down|nmod|END_ENTITY	Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic_cancer cells .
26504757	0	Bax	20,23	Bcl-xL	25,31	Bax	Bcl-xL	581	598	Gene	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Doxorubicin Changes Bax / Bcl-xL Ratio , Caspase-8_and_9 in Breast_Cancer Cells .
17158961	0	Bax	29,32	Bcl-xl	0,6	Bax	Bcl-xl	581	598	Gene	Gene	bind|dobj|START_ENTITY have|xcomp|bind have|nsubj|END_ENTITY	Bcl-xl does not have to bind Bax to protect T cells from death .
23994239	0	Bax	94,97	Bcl2	99,103	Bax	Bcl2	581	596	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Significant modulation of macrophages associated cytokines TNF-a , VEGF and apoptotoic protein Bax , Bcl2 abrogates_tumor cells .
26074734	0	Bax	17,20	Bcl2	44,48	Bax	Bcl2	581	596	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|regulation regulation|nmod|END_ENTITY	Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells .
19696224	0	Bax	71,74	Beta-catenin	0,12	Bax	Beta-catenin	581	1499	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax .
17447897	0	Bax	64,67	Bnip3	0,5	Bax	Bnip3	12028(Tax:10090)	12176(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Bnip3 mediates mitochondrial_dysfunction and cell death through Bax and Bak .
24633814	0	Bax	82,85	CDNF	11,15	Bax	CDNF	24887(Tax:10116)	361276(Tax:10116)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2 / Bax and caspase-3 activation .
24819963	0	Bax	53,56	CREB	88,92	Bax	CREB	24887(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
14612448	0	Bax	20,23	Calpain-1	0,9	Bax	Calpain-1	581	823	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis .
22736223	0	Bax	27,30	Connexin_43	0,11	Bax	Connexin 43	581	2697	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Connexin_43 interacts with Bax to regulate apoptosis of pancreatic_cancer through a gap junction-independent pathway .
11264286	0	Bax	101,104	Cytochrome_c	0,12	Bax	Cytochrome c	581	54205	Gene	Gene	regulated|nmod|START_ENTITY mechanisms|acl:relcl|regulated +|dep|mechanisms occurs|nmod|+ occurs|nsubj|release release|amod|END_ENTITY	Cytochrome_c release occurs via Ca2 + - dependent and Ca2 + - independent mechanisms that are regulated by Bax .
18042550	0	Bax	15,18	DJ-1	0,4	Bax	DJ-1	581	11315	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	DJ-1 decreases Bax expression through repressing p53 transcriptional activity .
16243436	0	Bax	113,116	DP5	49,52	Bax	DP5	24887(Tax:10116)	117271(Tax:10116)	Gene	Gene	dimmers|amod|START_ENTITY dimmers|dep|expression expression|nmod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16243436	0	Bax	98,101	DP5	49,52	Bax	DP5	24887(Tax:10116)	117271(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
19360319	0	Bax	37,40	EGFR	126,130	Bax	EGFR	581	1956	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|Bcl-2 Bcl-2|nmod|sample sample|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|acl|bearing bearing|dobj|deletion deletion|nmod|gene gene|amod|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
25997867	0	Bax	6,9	EGR-1	0,5	Bax	EGR-1	581	1958	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|appos|plays	EGR-1 / Bax pathway plays a role in vitamin E - tocotrienol-induced apoptosis in pancreatic_cancer cells .
16472596	0	Bax	53,56	Epidermal_growth_factor_receptor	0,32	Bax	Epidermal growth factor receptor	12028(Tax:10090)	13649(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|signaling signaling|compound|END_ENTITY	Epidermal_growth_factor_receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice .
22658447	0	Bax	18,21	Ghrelin	0,7	Bax	Ghrelin	24887(Tax:10116)	59301(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Ghrelin regulates Bax and PCNA but not Bcl-2 expressions following scrotal hyperthermia in the rat .
15525785	0	Bax	46,49	Glycogen_synthase_kinase-3beta	0,30	Bax	Glycogen synthase kinase-3beta	581	2932	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis .
21949018	0	Bax	29,32	IRF8	14,18	Bax	IRF8	12028(Tax:10090)	15900(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Cutting edge : IRF8 regulates Bax transcription in vivo in primary myeloid cells .
10998426	0	Bax	69,72	Insulin-like_growth_factor-binding_protein-3	0,44	Bax	Insulin-like growth factor-binding protein-3	581	3486	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Insulin-like_growth_factor-binding_protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast_cancer cells .
12879014	0	Bax	82,85	JNK	53,56	Bax	JNK	581	5599	Gene	Gene	activation|compound|START_ENTITY elicit|dobj|activation fails|xcomp|elicit fails|nsubj|activation activation|nmod|pathway pathway|appos|END_ENTITY	Selective activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3 ' - kinase -LRB- PI3K -RRB- pathway is inhibited .
15071501	0	Bax	13,16	JNK	0,3	Bax	JNK	581	5599	Gene	Gene	translocation|compound|START_ENTITY promotes|dobj|translocation promotes|nsubj|END_ENTITY	JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins .
16243436	0	Bax	113,116	JNK	166,169	Bax	JNK	24887(Tax:10116)	116554(Tax:10116)	Gene	Gene	dimmers|amod|START_ENTITY mediated|nsubjpass|dimmers mediated|nmod|c-Jun_N-terminal_kinase c-Jun_N-terminal_kinase|appos|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16243436	0	Bax	98,101	JNK	166,169	Bax	JNK	24887(Tax:10116)	116554(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY dimmers|dep|expression mediated|nsubjpass|dimmers mediated|nmod|c-Jun_N-terminal_kinase c-Jun_N-terminal_kinase|appos|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16458303	0	Bax	18,21	JNK	58,61	Bax	JNK	581	5599	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	The regulation of Bax by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- is a prerequisite to the mitochondrial-induced apoptotic pathway .
16709574	0	Bax	48,51	JNK	0,3	Bax	JNK	581	5599	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	JNK - and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells .
17113036	0	Bax	86,89	JNK	40,43	Bax	JNK	581	5599	Gene	Gene	activation|nmod|START_ENTITY signaling|dobj|activation signaling|nsubj|END_ENTITY	PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax .
18636161	0	Bax	62,65	JNK	108,111	Bax	JNK	581	5599	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
20709060	0	Bax	89,92	JNK	4,7	Bax	JNK	581	5599	Gene	Gene	translocation|compound|START_ENTITY accelerating|dobj|translocation enhances|advcl|accelerating enhances|nsubj|SP600125 SP600125|compound|END_ENTITY	The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung_adenocarcinoma cells .
11134353	0	Bax	27,30	Jak3	0,4	Bax	Jak3	12028(Tax:10090)	16453(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development .
14695629	0	Bax	16,19	Mcl-1	0,5	Bax	Mcl-1	581	4170	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|parataxis|associated	Mcl-1 and Bcl-2 / Bax ratio are associated with treatment response but not with Rai stage in B-cell_chronic_lymphocytic_leukemia .
18025305	0	Bax	21,24	Mcl-1	0,5	Bax	Mcl-1	581	4170	Gene	Gene	dependency|compound|START_ENTITY determines|dobj|dependency determines|nsubj|END_ENTITY	Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis .
22201517	0	Bax	42,45	Mcl-1	36,41	Bax	Mcl-1	24887(Tax:10116)	60430(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY changes|dep|expression changes|nmod|ratio ratio|nmod|END_ENTITY	Age-related changes in the ratio of Mcl-1 / Bax expression in the rat cochlea .
24680709	0	Bax	63,66	Mcl-1	20,25	Bax	Mcl-1	581	4170	Gene	Gene	translocation|compound|START_ENTITY trigger|dobj|translocation induces|advcl|trigger induces|dobj|degradation degradation|compound|END_ENTITY	Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma .
24865469	0	Bax	48,51	Mcl-1	144,149	Bax	Mcl-1	581	4170	Gene	Gene	Bim|compound|START_ENTITY peptides|nmod|Bim study|nmod|peptides bound|nsubj|study bound|nmod|protein protein|compound|END_ENTITY	Molecular dynamics study of segment peptides of Bax , Bim , and Mcl-1 BH3 domain of the apoptosis-regulating proteins bound to the anti-apoptotic Mcl-1 protein .
18644472	0	Bax	49,52	NBS1	0,4	Bax	NBS1	581	4683	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	NBS1 regulates a novel apoptotic pathway through Bax activation .
23340267	0	Bax	84,87	NFAT2	0,5	Bax	NFAT2	12028(Tax:10090)	18018(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY mediates|nmod|expression mediates|nsubj|END_ENTITY	NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression .
24819963	0	Bax	53,56	NFk-B	75,80	Bax	NFk-B	24887(Tax:10116)	81736(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
25975837	0	Bax	112,115	Noxa	79,83	Bax	Noxa	581	5366	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|compound|END_ENTITY	ALK-negative anaplastic_large_cell_lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2 .
11351299	0	Bax	0,3	P53	83,86	Bax	P53	581	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|thyroid_tumours thyroid_tumours|dep|dysregulation dysregulation|nmod|END_ENTITY	Bax expression in benign and malignant thyroid_tumours : dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid_carcinoma .
11351299	0	Bax	113,116	P53	83,86	Bax	P53	581	7157	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|nmod|thyroid_tumours thyroid_tumours|dep|dysregulation dysregulation|nmod|END_ENTITY	Bax expression in benign and malignant thyroid_tumours : dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid_carcinoma .
18604733	0	Bax	54,57	PCNA	64,68	Bax	PCNA	581	5111	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Apoptosis and proliferation related molecules -LRB- Bcl-2 , Bax , p53 , PCNA -RRB- in papillary_microcarcinoma versus papillary_carcinoma of the thyroid .
11842081	0	Bax	64,67	PI3K	35,39	Bax	PI3K	581	5293	Gene	Gene	3-kinase|dep|START_ENTITY 3-kinase|appos|END_ENTITY	The phosphatidylinositol 3-kinase -LRB- PI3K -RRB- - Akt pathway suppresses Bax translocation to mitochondria .
21158042	0	Bax	52,55	Rb1	12,15	Bax	Rb1	581	5925	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of Rb1 and Rg1 on the expression of Bcl-2 , Bax in apoptosis of HK-2 cells induced by the serum of kidney_ischemia / reperfusion -RSB- .
17346710	0	Bax	29,32	STAT1	0,5	Bax	STAT1	581	6772	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	STAT1 regulates p73-mediated Bax gene expression .
17548649	0	Bax	41,44	STAT1	0,5	Bax	STAT1	12028(Tax:10090)	20846(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY causes|dobj|translocation causes|nsubj|activation activation|compound|END_ENTITY	STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous_cell_hyperplasia by IFN-gamma .
23815903	0	Bax	72,75	TIEG1	14,19	Bax	TIEG1	581	7071	Gene	Gene	-RSB-|nsubj|START_ENTITY Influence|parataxis|-RSB- Influence|nmod|END_ENTITY	-LSB- Influence of TIEG1 on apoptosis of HL-60 cells and expression of Bcl-2 / Bax -RSB- .
25867342	0	Bax	53,56	TIEG1	10,15	Bax	TIEG1	581	7071	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of TIEG1 on apoptosis and expression of Bcl-2 / Bax and Pten in leukemic cell lines .
17096026	0	Bax	144,147	TOM22	0,5	Bax	TOM22	581	56993	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	TOM22 , a core component of the mitochondria outer membrane protein translocation pore , is a mitochondrial receptor for the proapoptotic protein Bax .
12902978	0	Bax	62,65	TRAIL	42,47	Bax	TRAIL	581	8743	Gene	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase_9-negative or Bcl-xL overexpressing cells .
22198199	0	Bax	52,55	Tom22	30,35	Bax	Tom22	581	56993	Gene	Gene	translocation|compound|START_ENTITY modulates|dobj|translocation modulates|nsubj|domain domain|nmod|END_ENTITY	The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast .
23994239	0	Bax	94,97	VEGF	66,70	Bax	VEGF	581	7422	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Significant modulation of macrophages associated cytokines TNF-a , VEGF and apoptotoic protein Bax , Bcl2 abrogates_tumor cells .
15964171	0	Bax	112,115	ataxin-7	23,31	Bax	ataxin-7	581	6314	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Polyglutamine-expanded ataxin-7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl-x -LRB- L -RRB- .
20546728	0	Bax	44,47	ataxin-7	23,31	Bax	ataxin-7	12028(Tax:10090)	246103(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons .
19139629	0	Bax	0,3	bak	7,10	Bax	bak	581	578	Gene	Gene	START_ENTITY|dep|/ /|parataxis|END_ENTITY	Bax - / - bak - / - cells exhibit p27 Thr198 phosphorylation and autophagy .
10233985	0	Bax	109,112	bcl-2	50,55	Bax	bcl-2	581	596	Gene	Gene	inhibits|nmod|START_ENTITY oncogene|acl:relcl|inhibits oncogene|amod|END_ENTITY	Epstein-Barr_virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak .
12481899	0	Bax	44,47	bcl-2	150,155	Bax	bcl-2	581	596	Gene	Gene	START_ENTITY|ccomp|reduce reduce|nmod|apoptosis apoptosis|nmod|manner manner|amod|END_ENTITY	Antisense oligonucleotides complementary to Bax transcripts reduce the susceptibility of B-cell_chronic_lymphocytic_leukaemia cells to apoptosis in a bcl-2 independent manner .
12539576	0	Bax	49,52	bcl-2	42,47	Bax	bcl-2	100355675(Tax:9986)	100009447(Tax:9986)	Gene	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	Study on apoptosis and expression of P53 , bcl-2 , Bax in cardiac myocytys of congestive_heart_failure induced by ventricular pacing .
12882813	0	Bax	35,38	bcl-2	13,18	Bax	bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	members|appos|START_ENTITY members|amod|END_ENTITY	Proapoptotic bcl-2 family members , Bax and Bak , are essential for developmental photoreceptor apoptosis .
16805752	0	Bax	0,3	bcl-2	5,10	Bax	bcl-2	581	596	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Bax , bcl-2 and c-kit expression in non-small-cell lung_cancer and their effects on prognosis .
19360919	0	Bax	97,100	bcl-2	91,96	Bax	bcl-2	581	596	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2 / Bax pathway .
11144029	0	Bax	0,3	caspase-3	61,70	Bax	caspase-3	12028(Tax:10090)	12367(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Bax and p53 are differentially involved in the regulation of caspase-3 expression and activation during neurodegeneration in Lurcher mice .
14612448	0	Bax	20,23	caspase-3	54,63	Bax	caspase-3	581	836	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis .
20203689	0	Bax	83,86	caspase-8	70,79	Bax	caspase-8	581	841	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Glucose_deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax - , Bak-deficient cells .
18992370	0	Bax	21,24	cytochrome-c	34,46	Bax	cytochrome-c	581	54205	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Putative partners in Bax mediated cytochrome-c release : ANT , CypD , VDAC or none of them ?
18722181	0	Bax	0,3	cytochrome_C	64,76	Bax	cytochrome C	581	54205	Gene	Gene	fission|amod|START_ENTITY uncoupled|nsubjpass|fission uncoupled|nmod|release release|amod|END_ENTITY	Bax - or Bak-induced mitochondrial fission can be uncoupled from cytochrome_C release .
10085289	0	Bax	37,40	cytochrome_c	74,86	Bax	cytochrome c	581	54205	Gene	Gene	change|nmod|START_ENTITY responsible|nsubj|change responsible|nmod|release release|amod|END_ENTITY	Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome_c release during apoptosis .
10514382	0	Bax	25,28	cytochrome_c	11,23	Bax	cytochrome c	581	54205	Gene	Gene	migration|amod|START_ENTITY migration|amod|END_ENTITY	Release of cytochrome_c , Bax migration , Bid cleavage , and activation of caspases 2 , 3 , 6 , 7 , 8 , and 9 during endothelial cell apoptosis .
10557088	0	Bax	0,3	cytochrome_c	67,79	Bax	cytochrome c	581	54205	Gene	Gene	membrane|compound|START_ENTITY insertion|nsubj|membrane insertion|parataxis|precedes precedes|dobj|release release|amod|END_ENTITY	Bax membrane insertion during Fas -LRB- CD95 -RRB- - induced apoptosis precedes cytochrome_c release and is inhibited by Bcl-2 .
10620504	0	Bax	0,3	cytochrome_c	89,101	Bax	cytochrome c	581	54205	Gene	Gene	oligomerization|compound|START_ENTITY required|nsubjpass|oligomerization required|nmod|liposomes liposomes|acl|trigger trigger|dobj|release release|amod|END_ENTITY	Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome_c release from mitochondria .
10717243	0	Bax	0,3	cytochrome_c	28,40	Bax	cytochrome c	581	54205	Gene	Gene	overexpression|compound|START_ENTITY enhances|nsubj|overexpression enhances|dobj|release release|amod|END_ENTITY	Bax overexpression enhances cytochrome_c release from mitochondria and sensitizes KATOIII gastric_cancer cells to chemotherapeutic agent-induced apoptosis .
10896657	1	Bax	65,68	cytochrome_c	137,149	Bax	cytochrome c	581	54205	Gene	Gene	Failure|nmod|START_ENTITY insertion|nsubj|Failure insertion|nmod|degrees degrees|acl:relcl|prevents prevents|dobj|release release|nmod|END_ENTITY	Failure of Bax insertion into mitochondria at 15 degrees C prevents the release of cytochrome_c .
11123425	0	Bax	0,3	cytochrome_c	60,72	Bax	cytochrome c	581	54205	Gene	Gene	induction|compound|START_ENTITY activates|nsubj|induction activates|dobj|cascade cascade|nmod|release release|amod|END_ENTITY	Bax induction activates apoptotic cascade via mitochondrial cytochrome_c release and Bax overexpression enhances apoptosis induced by chemotherapeutic agents in DLD-1 colon_cancer cells .
11281652	0	Bax	82,85	cytochrome_c	39,51	Bax	cytochrome c	581	54205	Gene	Gene	release|nmod|START_ENTITY release|nmod|translocation translocation|amod|END_ENTITY	Caspase-dependent cytosolic release of cytochrome_c and membrane translocation of Bax in p53-induced apoptosis .
12243190	0	Bax	0,3	cytochrome_c	13,25	Bax	cytochrome c	581	54205	Gene	Gene	releases|nsubj|START_ENTITY releases|dobj|preferentially preferentially|amod|END_ENTITY	Bax releases cytochrome_c preferentially from a complex between porin and adenine_nucleotide translocator .
14521400	0	Bax	106,109	cytochrome_c	81,93	Bax	cytochrome c	581	54205	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	3,6-dibromocarbazole _ piperazine derivatives of 2-propanol as first inhibitors of cytochrome_c release via Bax channel modulation .
15772159	0	Bax	11,14	cytochrome_c	46,58	Bax	cytochrome c	581	54205	Gene	Gene	component|nsubj|START_ENTITY component|nmod|MAC MAC|amod|END_ENTITY	Oligomeric Bax is a component of the putative cytochrome_c release channel MAC , mitochondrial apoptosis-induced channel .
17170750	0	Bax	0,3	cytochrome_c	78,90	Bax	cytochrome c	581	54205	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|release release|nmod|END_ENTITY	Bax and the mitochondrial permeability transition cooperate in the release of cytochrome_c during endoplasmic reticulum-stress-induced apoptosis .
17172466	0	Bax	74,77	cytochrome_c	102,114	Bax	cytochrome c	581	54205	Gene	Gene	activate|dobj|START_ENTITY activate|xcomp|induce induce|dobj|release release|amod|END_ENTITY	Reactive oxygen species and p38_mitogen-activated_protein_kinase activate Bax to induce mitochondrial cytochrome_c release and apoptosis in response to malonate .
17689609	0	Bax	51,54	cytochrome_c	11,23	Bax	cytochrome c	581	54205	Gene	Gene	translocation/activation|compound|START_ENTITY precedes|dobj|translocation/activation precedes|nsubj|Release Release|nmod|END_ENTITY	Release of cytochrome_c from mitochondria precedes Bax translocation/activation in Triton_X-100-induced apoptosis .
18546202	0	Bax	22,25	cytochrome_c	41,53	Bax	cytochrome c	581	54205	Gene	Gene	translocation|compound|START_ENTITY translocation|appos|release release|amod|END_ENTITY	Detailing the role of Bax translocation , cytochrome_c release , and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF .
18840646	0	Bax	62,65	cytochrome_c	25,37	Bax	cytochrome c	581	54205	Gene	Gene	redistribution|compound|START_ENTITY propagates|dobj|redistribution propagates|nsubj|wave wave|nmod|END_ENTITY	An intracellular wave of cytochrome_c propagates and precedes Bax redistribution during apoptosis .
18931364	0	Bax	0,3	cytochrome_c	107,119	Bax	cytochrome c	581	54205	Gene	Gene	act|nsubj|START_ENTITY act|xcomp|bring bring|dobj|apoptosis apoptosis|nmod|release release|nmod|END_ENTITY	Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome_c and subsequent caspase activation .
20304286	0	Bax	0,3	cytochrome_c	5,17	Bax	cytochrome c	581	54205	Gene	Gene	START_ENTITY|amod|staining staining|dep|END_ENTITY	Bax , cytochrome_c , and caspase-8 staining in parotid_cancer patients : markers of susceptibility in radiotherapy ?
21196320	0	Bax	68,71	cytochrome_c	90,102	Bax	cytochrome c	581	54205	Gene	Gene	+|compound|START_ENTITY mediated|nsubj|+ mediated|dobj|release release|amod|END_ENTITY	The respiratory-dependent assembly of ANT1 differentially regulates Bax and Ca2 + mediated cytochrome_c release .
21712378	0	Bax	93,96	cytochrome_c	149,161	Bax	cytochrome c	581	54205	Gene	Gene	oligomerization|compound|START_ENTITY induces|dobj|oligomerization induces|advcl|initiate initiate|dobj|release release|amod|END_ENTITY	Resveratrol induces p53-independent , X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- - mediated Bax protein oligomerization on mitochondria to initiate cytochrome_c release and caspase activation .
22479585	0	Bax	20,23	cytochrome_c	53,65	Bax	cytochrome c	581	54205	Gene	Gene	compensated|nmod|START_ENTITY compensated|xcomp|release release|xcomp|END_ENTITY	Bak compensated for Bax in p53-null cells to release cytochrome_c for the initiation of mitochondrial signaling during Withanolide_D-induced apoptosis .
23536162	0	Bax	0,3	cytochrome_c	12,24	Bax	cytochrome c	581	54205	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Bax induces cytochrome_c release by multiple mechanisms in mitochondria from MCF7 cells .
25275009	0	Bax	45,48	cytochrome_c	66,78	Bax	cytochrome c	581	54205	Gene	Gene	OMA1|nmod|START_ENTITY Activation|nmod|OMA1 promotes|nsubj|Activation promotes|dobj|release release|amod|END_ENTITY	Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome_c release during apoptosis .
9560217	0	Bax	0,3	cytochrome_c	32,44	Bax	cytochrome c	581	54205	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Bax directly induces release of cytochrome_c from isolated mitochondria .
14704000	0	Bax	66,69	inducible_nitric_oxide_synthase	25,56	Bax	inducible nitric oxide synthase	581	4843	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Correlated expression of inducible_nitric_oxide_synthase and P53 , Bax in benign and malignant diseased_gallbladder .
15782132	0	Bax	66,69	mTOR	148,152	Bax	mTOR	581	21977(Tax:10090)	Gene	Gene	ratio|compound|START_ENTITY increasing|dobj|ratio increasing|nmod|mechanisms mechanisms|nmod|activity activity|compound|END_ENTITY	Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity .
23108993	0	Bax	80,83	mTOR	74,78	Bax	mTOR	100355675(Tax:9986)	21977(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
14681224	0	Bax	26,29	p18	4,7	Bax	p18	581	100689229	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein .
12433990	0	Bax	125,128	p21	84,87	Bax	p21	581	644914	Gene	Gene	promoter|compound|START_ENTITY mediate|nmod|promoter mediate|nmod|promoter promoter|amod|END_ENTITY	Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter .
17302609	0	Bax	98,101	p21	40,43	Bax	p21	581	644914	Gene	Gene	associated|nsubjpass|START_ENTITY modulators|dep|associated modulators|dobj|proteins proteins|compound|Rb Rb|amod|END_ENTITY	Downregulation of cell cycle modulators p21 , p27 , p53 , Rb and proapoptotic Bcl-2-related proteins Bax and Bak in cutaneous melanoma is associated with worse patient prognosis : preliminary findings .
17615176	0	Bax	105,108	p38alpha	67,75	Bax	p38alpha	581	1432	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Epidermal_growth_factor_receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells .
10049778	0	Bax	109,112	p53	33,36	Bax	p53	12028(Tax:10090)	22060(Tax:10090)	Gene	Gene	apoptosis|nmod|START_ENTITY induction|nmod|apoptosis Effects|nmod|induction Effects|nmod|END_ENTITY	Effects of wild-type and mutated p53 and Id proteins on the induction of apoptosis by adenovirus E1A , c-Myc , Bax , and Nip3 in p53 null mouse cerebellum cells .
10200513	0	Bax	77,80	p53	13,16	Bax	p53	581	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO -1 by irradiation and ara-C treatment .
10641752	0	Bax	26,29	p53	7,10	Bax	p53	581	7157	Gene	Gene	ratios|amod|START_ENTITY protein|dep|ratios protein|compound|END_ENTITY	Mutant p53 protein , Bcl-2 / Bax ratios and apoptosis in paediatric acute_lymphoblastic_leukaemia .
10741712	0	Bax	44,47	p53	82,85	Bax	p53	581	7157	Gene	Gene	mediators|dobj|START_ENTITY mediators|nmod|transfer transfer|compound|END_ENTITY	Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung_cancer cells .
10873563	0	Bax	40,43	p53	60,63	Bax	p53	581	7157	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|hepatocellular_carcinomas hepatocellular_carcinomas|compound|END_ENTITY	Downregulation of proapoptotic proteins Bax and Bcl-X -LRB- S -RRB- in p53 overexpressing hepatocellular_carcinomas .
10935506	0	Bax	24,27	p53	8,11	Bax	p53	12028(Tax:10090)	22060(Tax:10090)	Gene	Gene	Driving|advcl|START_ENTITY Driving|dobj|response response|compound|END_ENTITY	Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis .
11044365	0	Bax	6,9	p53	77,80	Bax	p53	581	7157	Gene	Gene	ratio|compound|START_ENTITY predicts|nsubj|ratio predicts|dobj|sensitivity sensitivity|nmod|status status|compound|END_ENTITY	Bcl-2 / Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status .
11299743	0	Bax	0,3	p53	62,65	Bax	p53	581	7157	Gene	Gene	expression|compound|START_ENTITY expression|dep|association association|nmod|END_ENTITY	Bax protein expression in colorectal_cancer : association with p53 , bcl-2 and patterns of relapse .
11694525	0	Bax	105,108	p53	122,125	Bax	p53	581	7157	Gene	Gene	ratio|compound|START_ENTITY ratio|nmod|PaCa-2 PaCa-2|compound|END_ENTITY	Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2 / Bax ratio in the p53 mutant pancreatic_cancer cell line MIA PaCa-2 .
11748232	0	Bax	124,127	p53	52,55	Bax	p53	581	7157	Gene	Gene	promoter|compound|START_ENTITY transactivation|nmod|promoter transactivation|amod|END_ENTITY	HMGB1 and HMGB2 cell-specifically down-regulate the p53 - and p73-dependent sequence-specific transactivation from the human Bax gene promoter .
12203124	0	Bax	179,182	p53	153,156	Bax	p53	581	7157	Gene	Gene	encoding|dobj|START_ENTITY genes|acl|encoding genes|nummod|END_ENTITY	The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21 -LRB- CIP1/Waf1 -RRB- .
14634288	0	Bax	42,45	p53	63,66	Bax	p53	581	7157	Gene	Gene	gene|compound|START_ENTITY splicing|nmod|gene mediated|nsubj|splicing mediated|nmod|END_ENTITY	Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line .
15262986	0	Bax	14,17	p53	86,89	Bax	p53	581	7157	Gene	Gene	activation|compound|START_ENTITY Regulation|nmod|activation Regulation|nmod|pathways pathways|nummod|END_ENTITY	Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and - independent pathways .
15292938	0	Bax	31,34	p53	38,41	Bax	p53	581	7157	Gene	Gene	START_ENTITY|nmod|crypts crypts|nummod|END_ENTITY	Upregulation of p16 -LRB- INK4A -RRB- and Bax in p53 wild/p53-overexpressing crypts in ulcerative_colitis-associated_tumours .
18042550	0	Bax	15,18	p53	49,52	Bax	p53	581	7157	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|advcl|repressing repressing|dobj|activity activity|nummod|END_ENTITY	DJ-1 decreases Bax expression through repressing p53 transcriptional activity .
19360319	0	Bax	37,40	p53	32,35	Bax	p53	581	7157	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
20043868	0	Bax	68,71	p53	35,38	Bax	p53	581	7157	Gene	Gene	linked|xcomp|START_ENTITY linked|nsubjpass|Stabilization Stabilization|nmod|END_ENTITY	Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis .
20546728	0	Bax	44,47	p53	73,76	Bax	p53	12028(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|advcl|activating activating|dobj|END_ENTITY	Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons .
20567883	0	Bax	0,3	p53	22,25	Bax	p53	581	7157	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|pathway pathway|compound|END_ENTITY	Bax is upregulated by p53 signal pathway in the SPE B-induced apoptosis .
21092747	0	Bax	72,75	p53	0,3	Bax	p53	12028(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulation|nmod|expression mediates|dobj|upregulation mediates|nsubj|activation activation|compound|END_ENTITY	p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons .
21462329	0	Bax	10,13	p53	4,7	Bax	p53	581	7157	Gene	Gene	inhibition|amod|START_ENTITY -|appos|inhibition -|compound|END_ENTITY	The p53 - , Bax - and p21-dependent inhibition of colon_cancer cell growth by 5-hydroxy_polymethoxyflavones .
21485723	0	Bax	35,38	p53	40,43	Bax	p53	581	7157	Gene	Gene	caspase-3|dep|START_ENTITY caspase-3|dep|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
26124546	0	Bax	0,3	p53	38,41	Bax	p53	24887(Tax:10116)	301300(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|advcl|unaltered unaltered|nsubj|END_ENTITY	Bax modulates neuronal survival while p53 is unaltered after Cytochrome C induced oxidative stress in the adult olfactory bulb in vivo .
26833308	0	Bax	92,95	p53	65,68	Bax	p53	581	7157	Gene	Gene	upregulation|compound|START_ENTITY upregulation|compound|END_ENTITY	GSIV serine/threonine kinase can induce apoptotic cell death via p53 and pro-apoptotic gene Bax upregulation in fish cells .
9000137	0	Bax	59,62	p53	24,27	Bax	p53	581	7157	Gene	Gene	increase|nmod|START_ENTITY stimulates|dobj|increase stimulates|nsubj|Expression Expression|nmod|END_ENTITY	Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells .
9373250	0	Bax	140,143	p53	56,59	Bax	p53	581	7157	Gene	Gene	expression|nmod|START_ENTITY upregulates|nmod|expression upregulates|dobj|conformation conformation|nmod|END_ENTITY	Thrombopoietin upregulates the promoter conformation of p53 in a proliferation-independent manner coincident with a decreased expression of Bax : potential mechanisms for survival enhancing effects .
9699956	0	Bax	5,8	p53	0,3	Bax	p53	581	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	p53 , Bax and Bcl-2 expression , and apoptosis in gestational trophoblast of complete_hydatidiform_mole .
12670926	0	Bax	38,41	tumor_necrosis_factor-related_apoptosis-inducing_ligand	53,108	Bax	tumor necrosis factor-related apoptosis-inducing ligand	12028(Tax:10090)	22035(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of proapoptotic molecules Bax and Bak in tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced mitochondrial disruption and apoptosis : differential regulation of cytochrome c and Smac/DIABLO release .
18752120	0	Bax-interacting_factor-1	24,48	Bif-1	50,55	Bax-interacting factor-1	Bif-1	51100	51100	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of Bax-interacting_factor-1 -LRB- Bif-1 -RRB- in invasive urinary bladder and gallbladder_cancers .
19996103	0	Bax_inhibitor-1	8,23	IRE1alpha	33,42	Bax inhibitor-1	IRE1alpha	110213(Tax:10090)	78943(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Hepatic Bax_inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose_intolerance .
17726059	0	Bazooka	25,32	Cdc42	0,5	Bazooka	Cdc42	32703(Tax:7227)	32981(Tax:7227)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC .
10591217	0	Bazooka	0,7	Inscuteable	17,28	Bazooka	Inscuteable	32703(Tax:7227)	37355(Tax:7227)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts .
11516655	0	Bazooka	0,7	PAR-1	36,41	Bazooka	PAR-1	32703(Tax:7227)	2768852(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila .
17726059	0	Bazooka	25,32	aPKC	79,83	Bazooka	aPKC	32703(Tax:7227)	47594(Tax:7227)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|xcomp|regulate regulate|nmod|END_ENTITY	Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC .
20434988	0	Bazooka	24,31	aPKC	0,4	Bazooka	aPKC	32703(Tax:7227)	47594(Tax:7227)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	aPKC phosphorylation of Bazooka defines the apical/lateral _ border in Drosophila epithelial cells .
24173807	0	Bazooka	0,7	aPKC	17,21	Bazooka	aPKC	32703(Tax:7227)	47594(Tax:7227)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction .
22583914	0	Bb2	53,56	phosphatase_2A	38,52	Bb2	phosphatase 2A	2925	5524	Gene	Gene	regulates|nsubj|START_ENTITY phosphorylation|parataxis|regulates phosphorylation|nmod|END_ENTITY	N-terminal phosphorylation of protein phosphatase_2A / Bb2 regulates translocation to mitochondria , dynamin-related_protein_1 dephosphorylation , and neuronal survival .
25216264	0	Bbox1	32,37	MID1	27,31	Bbox1	MID1	8424	4281	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding .
25874572	0	Bbox1	133,138	MID1	115,119	Bbox1	MID1	8424	4281	Gene	Gene	Domain|compound|START_ENTITY Domain|compound|END_ENTITY	Molecular Dynamics Simulation Reveals Insights into the Mechanism of Unfolding by the A130T/V Mutations within the MID1 Zinc-Binding Bbox1 Domain .
25874572	0	Bbox1	133,138	MID1	115,119	Bbox1	MID1	8424	4281	Gene	Gene	Domain|compound|START_ENTITY Domain|compound|END_ENTITY	Molecular Dynamics Simulation Reveals Insights into the Mechanism of Unfolding by the A130T/V Mutations within the MID1 Zinc-Binding Bbox1 Domain .
17079274	0	Bchs	0,4	Rab11	42,47	Bchs	Rab11	33819(Tax:7227)	42501(Tax:7227)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Bchs , a BEACH domain protein , antagonizes Rab11 in synapse morphogenesis and other developmental events .
23675312	0	Bck2	0,4	Mcm1	39,43	Bck2	Mcm1	856914(Tax:4932)	855060(Tax:4932)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast .
22468037	0	Bcl-1	13,18	Glucocorticoid_Receptor	40,63	Bcl-1	Glucocorticoid Receptor	595	2908	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|nmod|Gene Gene|compound|END_ENTITY	Influence of Bcl-1 Gene Polymorphism of Glucocorticoid_Receptor Gene -LRB- NR3C1 , rs41423247 -RRB- on Blood Pressure , Glucose in Northern Indians .
11526431	0	Bcl-2	28,33	A1-a	49,53	Bcl-2	A1-a	596	5265	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	Transient expression of the Bcl-2 family member , A1-a , results in nuclear localization and resistance to staurosporine-induced apoptosis .
11418133	0	Bcl-2	79,84	AK-5	40,44	Bcl-2	AK-5	24224(Tax:10116)	301115(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Differential regulation of apoptosis in AK-5 tumor cells by the proto-oncogene Bcl-2 : presence of Bcl-2 dependent and independent pathways .
11418133	0	Bcl-2	98,103	AK-5	40,44	Bcl-2	AK-5	24224(Tax:10116)	301115(Tax:10116)	Gene	Gene	pathways|amod|START_ENTITY presence|nmod|pathways regulation|dep|presence regulation|nmod|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	Differential regulation of apoptosis in AK-5 tumor cells by the proto-oncogene Bcl-2 : presence of Bcl-2 dependent and independent pathways .
11598802	0	Bcl-2	127,132	AK-5	26,30	Bcl-2	AK-5	24224(Tax:10116)	301115(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY cytochrome|dobj|release cytochrome|nsubj|Induction Induction|nmod|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	Induction of apoptosis in AK-5 tumor cells by a serum factor from tumor rejecting animals : cytochrome c release independent of Bcl-2 and caspases .
17131910	0	Bcl-2	95,100	AK-5	57,61	Bcl-2	AK-5	24224(Tax:10116)	301115(Tax:10116)	Gene	Gene	downregulation|nmod|START_ENTITY involves|dobj|downregulation involves|nsubj|Heat_stress Heat_stress|acl|induced induced|nmod|cells cells|acl|derived derived|nmod|tumor tumor|compound|END_ENTITY	Heat_stress induced apoptosis in BC-8 cells derived from AK-5 tumor involves downregulation of Bcl-2 and generation of reactive oxygen species .
17026529	0	Bcl-2	134,139	AP-1	41,45	Bcl-2	AP-1	24224(Tax:10116)	24516(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY c-Fos|nmod|expression involvement|nmod|c-Fos pathway|dep|involvement generate|nmod|pathway generate|dobj|complexes complexes|compound|END_ENTITY	PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway : involvement of c-Fos in PACAP-induced Bcl-2 expression .
24819963	0	Bcl-2	58,63	AP-1	82,86	Bcl-2	AP-1	24224(Tax:10116)	24516(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
26819684	0	Bcl-2	110,115	Annexin_V	94,103	Bcl-2	Annexin V	24224(Tax:10116)	25673(Tax:10116)	Gene	Gene	Levels|dep|START_ENTITY Levels|compound|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
23207240	0	Bcl-2	95,100	Apaf-1	22,28	Bcl-2	Apaf-1	596	317	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins .
27041273	0	Bcl-2	104,109	B-Cell_Lymphoma_2	85,102	Bcl-2	B-Cell Lymphoma 2	596	596	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Cotton_Leaf_Curl_Multan_Betasatellite DNA as a Tool to Deliver and Express the Human B-Cell_Lymphoma_2 -LRB- Bcl-2 -RRB- Gene in Plants .
11483855	0	Bcl-2	61,66	BAD	20,23	Bcl-2	BAD	596	572	Gene	Gene	proteins|compound|START_ENTITY interacts|nmod|proteins interacts|nsubj|END_ENTITY	Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis .
11699408	0	Bcl-2	47,52	BAD	0,3	Bcl-2	BAD	596	572	Gene	Gene	over-expressing|dobj|START_ENTITY cells|acl|over-expressing apoptosis|nmod|cells induces|dobj|apoptosis induces|nsubj|END_ENTITY	BAD induces apoptosis in cells over-expressing Bcl-2 or Bcl-xL without loss of mitochondrial membrane potential .
12404123	0	Bcl-2	106,111	BAD	34,37	Bcl-2	BAD	596	572	Gene	Gene	interaction|nmod|START_ENTITY signals|nmod|interaction transduces|dobj|signals transduces|nsubj|END_ENTITY	The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2 .
9389536	0	Bcl-2	42,47	BAD	102,105	Bcl-2	BAD	24224(Tax:10116)	64639(Tax:10116)	Gene	Gene	Bcl-XL/Bcl|amod|START_ENTITY Expression|nmod|Bcl-XL/Bcl Expression|dep|associated_death_promoter associated_death_promoter|appos|END_ENTITY	Expression and function of a proapoptotic Bcl-2 family member Bcl-XL/Bcl -2 - associated_death_promoter -LRB- BAD -RRB- in rat ovary .
23455184	0	Bcl-2	14,19	BAG	42,45	Bcl-2	BAG	596	573	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian_cancer .
20605789	0	Bcl-2	59,64	BAK	26,29	Bcl-2	BAK	596	578	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Conformational changes in BAK , a pore-forming proapoptotic Bcl-2 family member , upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers .
20374575	0	Bcl-2	141,146	BAX	135,138	Bcl-2	BAX	596	581	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Coenzyme_Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX / Bcl-2 ratio .
9096220	0	Bcl-2	14,19	BCR-ABL	39,46	Bcl-2	BCR-ABL	596	25	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of Bcl-2 gene expression by BCR-ABL is mediated by Ras .
11373297	0	Bcl-2	108,113	BHRF1	86,91	Bcl-2	BHRF1	596	3783706(Tax:10376)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , through direct interaction .
16963744	0	Bcl-2	97,102	BHRF1	75,80	Bcl-2	BHRF1	596	3783706(Tax:10376)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Human cellular protein VRK2 interacts specifically with Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , and enhances cell survival .
8910674	0	Bcl-2	72,77	BHRF1	28,33	Bcl-2	BHRF1	596	3783706(Tax:10376)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The Epstein-Barr_virus gene BHRF1 , a homologue of the cellular oncogene Bcl-2 , inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs .
16217754	0	Bcl-2	19,24	BNIP3	40,45	Bcl-2	BNIP3	596	664	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	The pro-cell death Bcl-2 family member , BNIP3 , is localized to the nucleus of human glial cells : Implications for glioblastoma_multiforme_tumor cell survival under hypoxia .
19745227	0	Bcl-2	44,49	BNIP3	1,6	Bcl-2	BNIP3	596	664	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	-LSB- BNIP3 as an atypical representative of the Bcl-2 protein family .
19745228	0	Bcl-2	44,49	BNIP3	1,6	Bcl-2	BNIP3	596	664	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	-LSB- BNIP3 as an atypical representative of the Bcl-2 protein family .
12901880	0	Bcl-2	53,58	BNIPL-2	0,7	Bcl-2	BNIPL-2	596	149428	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BNIPL-2 , a novel homologue of BNIP-2 , interacts with Bcl-2 and Cdc42GAP in apoptosis .
11390485	0	Bcl-2	0,5	Bad	45,48	Bcl-2	Bad	596	572	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|alpha alpha|dep|END_ENTITY	Bcl-2 targets protein phosphatase 1 alpha to Bad .
14597423	0	Bcl-2	100,105	Bad	120,123	Bcl-2	Bad	596	572	Gene	Gene	member|compound|START_ENTITY phosporylation|nmod|member END_ENTITY|nsubj|phosporylation	The Us3 protein kinase of herpes_simplex_virus_1 blocks apoptosis and induces phosporylation of the Bcl-2 family member Bad .
15751984	0	Bcl-2	72,77	Bad	102,105	Bcl-2	Bad	596	572	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nsubj|protein	A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad .
17557568	0	Bcl-2	55,60	Bad	74,77	Bcl-2	Bad	596	572	Gene	Gene	genes|compound|START_ENTITY domains|nmod|genes analysis|nmod|domains analysis|dep|END_ENTITY	Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad , Bmf and Bcl-G in laryngeal_squamous_cell_carcinomas .
21472231	0	Bcl-2	116,121	Bad	154,157	Bcl-2	Bad	596	572	Gene	Gene	family|compound|START_ENTITY Immunoexpression|nmod|family apoptotic|dep|Immunoexpression apoptotic|appos|Bak Bak|dep|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21472231	0	Bcl-2	130,135	Bad	154,157	Bcl-2	Bad	596	572	Gene	Gene	Bak|compound|START_ENTITY Bak|dep|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
10369703	0	Bcl-2	105,110	Bak	84,87	Bcl-2	Bak	596	578	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Human right and left colon differ in epithelial cell apoptosis and in expression of Bak , a pro-apoptotic Bcl-2 homologue .
11278671	0	Bcl-2	16,21	Bak	63,66	Bcl-2	Bak	596	578	Gene	Gene	variant|compound|START_ENTITY variant|nmod|END_ENTITY	Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons , but pro-apoptotic in non-neuronal cells .
7715731	0	Bcl-2	50,55	Bak	66,69	Bcl-2	Bak	596	578	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak .
9457070	0	Bcl-2	45,50	Basic_fibroblast_growth_factor	0,30	Bcl-2	Basic fibroblast growth factor	596	2247	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast_cancer cells .
10374878	0	Bcl-2	69,74	Bax	75,78	Bcl-2	Bax	596	581	Gene	Gene	correlates|nmod|START_ENTITY correlates|dep|expression expression|compound|END_ENTITY	Inhibition of constitutively activated Stat3 correlates with altered Bcl-2 / Bax expression and induction of apoptosis in mycosis_fungoides_tumor cells .
10381168	0	Bcl-2	18,23	Bax	36,39	Bcl-2	Bax	596	581	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|dep|not not|dep|END_ENTITY	Downregulation of Bcl-2 , but not of Bax or Bcl-x , is associated with T lymphocyte apoptosis in HIV_infection and restored by antiretroviral therapy or by interleukin 2 .
10391451	0	Bcl-2	0,5	Bax	7,10	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	kainic_acid|advmod|START_ENTITY kainic_acid|nsubj|END_ENTITY	Bcl-2 , Bax and Bcl-x expression following kainic_acid administration at convulsant doses in the rat .
10395708	0	Bcl-2	89,94	Bax	95,98	Bcl-2	Bax	596	581	Gene	Gene	imbalance|compound|START_ENTITY imbalance|compound|END_ENTITY	Resistance of Crohn 's _ disease T cells to multiple apoptotic signals is associated with a Bcl-2 / Bax mucosal imbalance .
10400666	0	Bcl-2	27,32	Bax	75,78	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY functional|nsubj|domain functional|nmod|heterodimerization heterodimerization|nmod|END_ENTITY	NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis .
10472781	0	Bcl-2	55,60	Bax	61,64	Bcl-2	Bax	596	581	Gene	Gene	effects|nmod|START_ENTITY effects|parataxis|apoptosis apoptosis|nsubj|END_ENTITY	Differential effects of chemotherapeutic agents on the Bcl-2 / Bax apoptosis pathway in human breast_cancer cell line MCF-7 .
10554032	0	Bcl-2	108,113	Bax	30,33	Bcl-2	Bax	596	581	Gene	Gene	regulated|nmod|START_ENTITY factor|acl|regulated involves|dobj|factor mitochondria|acl:relcl|involves facilitates|nmod|mitochondria facilitates|dobj|translocation translocation|compound|END_ENTITY	Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2 .
10573132	0	Bcl-2	4,9	Bax	0,3	Bcl-2	Bax	596	581	Gene	Gene	modulation|compound|START_ENTITY important|nsubj|modulation END_ENTITY|parataxis|important	Bax : Bcl-2 ratio modulation by bryostatin_1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute_lymphoblastic_leukemia cell line , Reh .
10591516	0	Bcl-2	35,40	Bax	41,44	Bcl-2	Bax	100009447(Tax:9986)	100355675(Tax:9986)	Gene	Gene	changes|nmod|START_ENTITY changes|dep|ratio ratio|compound|END_ENTITY	Age-related hippocampal changes in Bcl-2 : Bax ratio , oxidative stress , redox-active iron and apoptosis associated with aluminum-induced neurodegeneration : increased susceptibility with aging .
10628333	0	Bcl-2	18,23	Bax	24,27	Bcl-2	Bax	596	581	Gene	Gene	Alteration|nmod|START_ENTITY Alteration|dep|status status|compound|END_ENTITY	Alteration of the Bcl-2 / Bax status of head_and_neck_cancer cell lines by chemotherapeutic agents .
10641752	0	Bcl-2	20,25	Bax	26,29	Bcl-2	Bax	596	581	Gene	Gene	protein|amod|START_ENTITY protein|dep|ratios ratios|amod|END_ENTITY	Mutant p53 protein , Bcl-2 / Bax ratios and apoptosis in paediatric acute_lymphoblastic_leukaemia .
10658530	0	Bcl-2	8,13	Bax	31,34	Bcl-2	Bax	596	581	Gene	Gene	proteins|compound|START_ENTITY Role|nmod|proteins Role|dep|END_ENTITY	Role of Bcl-2 family proteins -LRB- Bax , Bcl-2 and Bcl-X -RRB- on cellular susceptibility to radiation in pancreatic_cancer cells .
10705244	0	Bcl-2	0,5	Bax	7,10	Bcl-2	Bax	596	581	Gene	Gene	START_ENTITY|appos|Bcl-x Bcl-x|compound|END_ENTITY	Bcl-2 , Bax , Bcl-x -LRB- L -RRB- and Bcl-x -LRB- S -RRB- expression in neoplastic and normal endometrium .
10751382	0	Bcl-2	0,5	Bax	58,61	Bcl-2	Bax	596	581	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|change change|nmod|terminus terminus|compound|END_ENTITY	Bcl-2 inhibits a Fas-induced conformational change in the Bax N terminus and Bax mitochondrial translocation .
10806802	0	Bcl-2	26,31	Bax	33,36	Bcl-2	Bax	596	581	Gene	Gene	Fas/Apo|compound|START_ENTITY Fas/Apo|appos|END_ENTITY	The protein expression of Bcl-2 , Bax , Fas/Apo -1 in acute_myeloid_leukemia .
10806835	0	Bcl-2	38,43	Bax	44,47	Bcl-2	Bax	596	581	Gene	Gene	relationship|nmod|START_ENTITY Study|nmod|relationship Study|dep|ratio ratio|compound|END_ENTITY	Study on the relationship between the Bcl-2 / Bax ratio and the growth types of leukemic cells and drug resistance in acute_myelogenous_leukemia .
10936684	0	Bcl-2	48,53	Bax	43,46	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Changes in apoptosis-related protein -LRB- p53 , Bax , Bcl-2 and Fos -RRB- expression with DNA fragmentation in the central nervous system in rats after closed_head_injury .
11041112	0	Bcl-2	22,27	Bax	46,49	Bcl-2	Bax	596	581	Gene	Gene	Heterodimerization|nmod|START_ENTITY Heterodimerization|nmod|END_ENTITY	Heterodimerization of Bcl-2 and Bcl-X -LRB- L -RRB- with Bax and Bad in colorectal_cancer .
11044365	0	Bcl-2	0,5	Bax	6,9	Bcl-2	Bax	596	581	Gene	Gene	START_ENTITY|parataxis|predicts predicts|nsubj|ratio ratio|compound|END_ENTITY	Bcl-2 / Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status .
11060313	0	Bcl-2	101,106	Bax	85,88	Bcl-2	Bax	596	581	Gene	Gene	homology|compound|START_ENTITY END_ENTITY|nmod|homology	MAP-1 , a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains .
11205251	0	Bcl-2	34,39	Bax	84,87	Bcl-2	Bax	596	581	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein expression|dep|correlation correlation|nmod|indices indices|compound|END_ENTITY	Immunohistochemical expression of Bcl-2 protein in breast lesions : correlation with Bax , p53 , Rb , C-erbB-2 , EGFR and proliferation indices .
11245018	0	Bcl-2	0,5	Bax	32,35	Bcl-2	Bax	596	581	Gene	Gene	gene|amod|START_ENTITY genes|nsubj|gene genes|dobj|END_ENTITY	Bcl-2 gene and its family genes Bax , Bcl-Xl as well as Fas/Apo -1 and their clinical significance in acute_leukemia .
11259385	0	Bcl-2	199,204	Bax	205,208	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	A low-molecular-weight fraction of human seminal plasma activates adenylyl cyclase and induces caspase_3-independent apoptosis in prostatic epithelial cells by decreasing mitochondrial potential and Bcl-2 / Bax ratio .
11278245	0	Bcl-2	15,20	Bax	75,78	Bcl-2	Bax	596	581	Gene	Gene	member|compound|START_ENTITY member|acl:relcl|binds binds|dobj|END_ENTITY	Bcl-B , a novel Bcl-2 family member that differentially binds and regulates Bax and Bak .
11279112	0	Bcl-2	0,5	Bax	15,18	Bcl-2	Bax	596	581	Gene	Gene	prevents|nsubj|START_ENTITY prevents|dobj|oligomerization oligomerization|compound|END_ENTITY	Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane .
11410528	0	Bcl-2	41,46	Bax	105,108	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	members|compound|START_ENTITY proteins|dep|members fail|nsubj|proteins fail|xcomp|induce induce|nmod|absence absence|nmod|END_ENTITY	BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak .
11509139	0	Bcl-2	101,106	Bax	96,99	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Modulation of angelica sinensis polysaccharides on the expression of nitric_oxide synthase and Bax , Bcl-2 in liver of immunological liver-injured mice -RSB- .
11694525	0	Bcl-2	99,104	Bax	105,108	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2 / Bax ratio in the p53 mutant pancreatic_cancer cell line MIA PaCa-2 .
11726273	0	Bcl-2	27,32	Bax	16,19	Bcl-2	Bax	596	581	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bcl-2	27,32	Bax	33,36	Bcl-2	Bax	596	581	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|parataxis|triggered triggered|nsubj|heterodimer heterodimer|compound|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bcl-2	94,99	Bax	16,19	Bcl-2	Bax	596	581	Gene	Gene	serine|nmod|START_ENTITY phosphorylation|nmod|serine triggered|nmod|phosphorylation Dissociation|parataxis|triggered Dissociation|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bcl-2	94,99	Bax	33,36	Bcl-2	Bax	596	581	Gene	Gene	serine|nmod|START_ENTITY phosphorylation|nmod|serine triggered|nmod|phosphorylation triggered|nsubj|heterodimer heterodimer|compound|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11768244	0	Bcl-2	0,5	Bax	6,9	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Bcl-2 / Bax protein expression in heart , slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions .
11839683	0	Bcl-2	83,88	Bax	111,114	Bcl-2	Bax	596	581	Gene	Gene	hyperphosphorylation|compound|START_ENTITY hyperphosphorylation|appos|up-regulation up-regulation|compound|END_ENTITY	Protein kinase A RIalpha antisense inhibition of PC3M_prostate_cancer cell growth : Bcl-2 hyperphosphorylation , Bax up-regulation , and Bad-hypophosphorylation .
11858462	0	Bcl-2	18,23	Bax	24,27	Bcl-2	Bax	596	581	Gene	Gene	Alteration|nmod|START_ENTITY Alteration|dep|ratio ratio|compound|END_ENTITY	Alteration of the Bcl-2 : Bax ratio in the placenta as pregnancy proceeds .
11875499	0	Bcl-2	111,116	Bax	125,128	Bcl-2	Bax	596	581	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	Tumor-cell resistance to death receptor -- induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax .
11920608	0	Bcl-2	109,114	Bax	143,146	Bcl-2	Bax	596	581	Gene	Gene	level|nmod|START_ENTITY correlated|nmod|level correlated|nmod|status status|compound|END_ENTITY	Resistance of colon_cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X -LRB- L -RRB- in addition to Bax and p53 status .
11937734	0	Bcl-2	78,83	Bax	84,87	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Lymphocytes treated by extracorporeal photopheresis demonstrate a drop in the Bcl-2 / Bax ratio : a possible mechanism involved in extracorporeal-photopheresis-induced apoptosis .
11980885	0	Bcl-2	108,113	Bax	0,3	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY necessary|nmod|activity partner|amod|necessary partner|nsubj|END_ENTITY	Bax is not the heterodimerization partner necessary for sustained anti-photoreceptor-cell-death activity of Bcl-2 .
12170776	0	Bcl-2	116,121	Bax	46,49	Bcl-2	Bax	596	581	Gene	Gene	status|compound|START_ENTITY cells|nmod|status apoptosis|nmod|cells induces|dobj|apoptosis induces|nsubj|adenovirus adenovirus|acl|expressing expressing|dobj|END_ENTITY	A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate_cancer cells independently of their Bcl-2 status and androgen sensitivity .
12183413	0	Bcl-2	169,174	Bax	175,178	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis , as well as increased mitochondrial efficiency , superoxide dismutase activity , and Bcl-2 : Bax ratio .
12198774	0	Bcl-2	49,54	Bax	42,45	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Negative correlation between the ratio of Bax to Bcl-2 and the size of tumor treated by culture supernatants from Kupffer cells .
12477729	0	Bcl-2	0,5	Bax	45,48	Bcl-2	Bax	596	581	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins .
12490780	0	Bcl-2	88,93	Bax	13,16	Bcl-2	Bax	596	581	Gene	Gene	islets|nmod|START_ENTITY hyperexpressed|nmod|islets hyperexpressed|nsubjpass|END_ENTITY	Proapoptotic Bax is hyperexpressed in isolated human islets compared with antiapoptotic Bcl-2 .
12761582	0	Bcl-2	60,65	Bax	24,27	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|development development|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Lymphoma development in Bax transgenic_mice is inhibited by Bcl-2 and associated with chromosomal instability .
12803975	0	Bcl-2	37,42	Bax	33,36	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY alterations|dep|ratio alterations|nmod|END_ENTITY	Temporal alterations in cellular Bax : Bcl-2 ratio following traumatic brain_injury in the rat .
12887767	0	Bcl-2	52,57	Bax	58,61	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|L L|compound|END_ENTITY	-LSB- Expression and function of apoptosis-related genes Bcl-2 / Bax and Fas/Fas _ L in the course of stress ulcer -RSB- .
12925958	0	Bcl-2	44,49	Bax	75,78	Bcl-2	Bax	596	581	Gene	Gene	homologue|compound|START_ENTITY NS5A|nmod|homologue interacts|nsubj|NS5A interacts|nmod|END_ENTITY	Hepatitis_C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular_carcinoma .
14531950	0	Bcl-2	88,93	Bax	79,82	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	implanted|nmod|START_ENTITY implanted|dobj|hepatoma hepatoma|dep|overexpression overexpression|nmod|END_ENTITY	Nimesulide inhibits tumor growth in mice implanted hepatoma : overexpression of Bax over Bcl-2 .
14572466	0	Bcl-2	69,74	Bax	14,17	Bcl-2	Bax	596	581	Gene	Gene	Ser-70|nmod|START_ENTITY translocation|nmod|Ser-70 translocation|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Bax translocation through phosphorylation at Ser-70 of Bcl-2 by MAP kinase in NO-induced neuronal apoptosis .
14672562	0	Bcl-2	106,111	Bax	112,115	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2 / Bax expression .
14681224	0	Bcl-2	45,50	Bax	26,29	Bcl-2	Bax	596	581	Gene	Gene	protein|amod|START_ENTITY behaves|nmod|protein behaves|nsubj|form form|nmod|END_ENTITY	The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein .
15030235	0	Bcl-2	19,24	Bax	25,28	Bcl-2	Bax	596	581	Gene	Gene	Modulations|nmod|START_ENTITY Modulations|parataxis|involved involved|nsubjpass|family family|compound|END_ENTITY	Modulations of the Bcl-2 / Bax family were involved in the chemopreventive effects of licorice root -LRB- Glycyrrhiza uralensis Fisch -RRB- in MCF-7 human breast_cancer cell .
15078907	0	Bcl-2	7,12	Bax	0,3	Bcl-2	Bax	596	581	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|nmod|ratio	Bax to Bcl-2 ratio and Ki-67 index are useful predictors of neoadjuvant chemoradiation therapy in bladder_cancer .
15132839	0	Bcl-2	68,73	Bax	74,77	Bcl-2	Bax	596	581	Gene	Gene	expression|nmod|START_ENTITY altering|dobj|expression altering|dep|END_ENTITY	Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2 / Bax and activating caspase-3 / ICAD pathway .
15159016	0	Bcl-2	72,77	Bax	78,81	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2 / Bax ratio .
15231068	0	Bcl-2	20,25	Bax	27,30	Bcl-2	Bax	596	581	Gene	Gene	partners|nmod|START_ENTITY partners|dep|END_ENTITY	Nuclear partners of Bcl-2 : Bax and PML .
15302859	0	Bcl-2	0,5	Bax	157,160	Bcl-2	Bax	596	581	Gene	Gene	homodimerization|amod|START_ENTITY involves|nsubj|homodimerization involves|dobj|surfaces surfaces|appos|arrangement arrangement|acl:relcl|provides provides|xcomp|capture capture|dobj|END_ENTITY	Bcl-2 homodimerization involves two distinct binding surfaces , a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax .
15302859	0	Bcl-2	130,135	Bax	157,160	Bcl-2	Bax	596	581	Gene	Gene	mechanism|nmod|START_ENTITY provides|dobj|mechanism provides|xcomp|capture capture|dobj|END_ENTITY	Bcl-2 homodimerization involves two distinct binding surfaces , a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax .
15467752	0	Bcl-2	12,17	Bax	26,29	Bcl-2	Bax	596	581	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL_and_5-FU through the mitochondrial apoptosis pathway .
15563666	0	Bcl-2	127,132	Bax	120,123	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY associated|nmod|ratio associated|nmod|END_ENTITY	MUC4 is increased in high grade intraepithelial_neoplasia in Barrett 's _ oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio .
15588281	0	Bcl-2	110,115	Bax	106,109	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Dexamethasone protected human glioblastoma U87MG cells from temozolomide induced apoptosis by maintaining Bax : Bcl-2 ratio and preventing proteolytic activities .
15661735	0	Bcl-2	63,68	Bax	69,72	Bcl-2	Bax	596	581	Gene	Gene	BimEL|amod|START_ENTITY BimEL|compound|END_ENTITY	Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2 / Bax family protein BimEL .
15703493	0	Bcl-2	112,117	Bax	105,108	Bcl-2	Bax	596	581	Gene	Gene	upregulating|nmod|START_ENTITY upregulating|dobj|ratio ratio|nmod|END_ENTITY	Bovine herpesvirus VP22 induces apoptosis in neuroblastoma cells by upregulating the expression ratio of Bax to Bcl-2 .
15714115	1	Bcl-2	80,85	Bax	86,89	Bcl-2	Bax	596	581	Gene	Gene	study|nmod|START_ENTITY study|dep|expression expression|compound|END_ENTITY	A study of Bcl-2 / Bax expression and keratinocyte rescue effects .
15807260	0	Bcl-2	20,25	Bax	15,18	Bcl-2	Bax	493934(Tax:9685)	493837(Tax:9685)	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of Bax , Bcl-2 and caspase-3 in spared dorsal root ganglion after partial dorsal root rhizotomy -RSB- .
15881612	0	Bcl-2	128,133	Bax	134,137	Bcl-2	Bax	596	581	Gene	Gene	rheostat|compound|START_ENTITY rheostat|compound|END_ENTITY	Sphingosine_1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2 / Bax rheostat .
15923092	0	Bcl-2	44,49	Bax	50,53	Bcl-2	Bax	101833785	101842912	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Di - -LRB- 2-ethylhexyl -RRB- phthalate -LRB- DEHP -RRB- increases Bcl-2 / Bax ratio and modifies c-myc expression in Syrian_hamster embryo -LRB- SHE -RRB- cells .
15935058	0	Bcl-2	78,83	Bax	98,101	Bcl-2	Bax	596	581	Gene	Gene	applied|nmod|START_ENTITY applied|dobj|END_ENTITY	Fibroblast_growth_factor_2 applied to the optic nerve after axotomy increases Bcl-2 and decreases Bax in ganglion cells by activating the extracellular_signal-regulated_kinase signaling pathway .
15948248	0	Bcl-2	127,132	Bax	133,136	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Intravenous acid fibroblast growth factor protects intestinal mucosal cells against ischemia-reperfusion_injury via regulating Bcl-2 / Bax expression .
15960274	0	Bcl-2	1,6	Bax	7,10	Bcl-2	Bax	596	581	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	-LSB- Bcl-2 / Bax gene expression in different types of carotid plaque -RSB- .
16009487	0	Bcl-2	16,21	Bax	80,83	Bcl-2	Bax	596	581	Gene	Gene	Upregulation|nmod|START_ENTITY associated|nsubjpass|Upregulation associated|nmod|cisplatin-resistance cisplatin-resistance|nmod|inhibition inhibition|nmod|translocation translocation|compound|END_ENTITY	Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder_cancer cells .
16023593	0	Bcl-2	37,42	Bax	43,46	Bcl-2	Bax	596	581	Gene	Gene	flipping|dobj|START_ENTITY Killing|advcl|flipping END_ENTITY|dep|Killing	Killing cancer cells by flipping the Bcl-2 / Bax switch .
16132718	0	Bcl-2	45,50	Bax	38,41	Bcl-2	Bax	596	581	Gene	Gene	modifies|xcomp|START_ENTITY modifies|dobj|END_ENTITY	Overexpression of human GPX1 modifies Bax to Bcl-2 apoptotic ratio in human endothelial cells .
16188096	0	Bcl-2	13,18	Bax	20,23	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	-LSB- DNA damage , Bcl-2 , Bax expression and ultrastructure change in spermatogenic cell of mice exposed to cadmium -RSB- .
16243436	0	Bcl-2	107,112	Bax	113,116	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	Bax|nmod|START_ENTITY expression|appos|Bax dimmers|dep|expression dimmers|amod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16407825	0	Bcl-2	30,35	Bax	0,3	Bcl-2	Bax	596	581	Gene	Gene	members|compound|START_ENTITY END_ENTITY|appos|members	Bax and Bid , two proapoptotic Bcl-2 family members , inhibit homologous recombination , independently of apoptosis regulation .
16510597	0	Bcl-2	43,48	Bax	66,69	Bcl-2	Bax	596	581	Gene	Gene	interaction|compound|START_ENTITY prevents|dobj|interaction prevents|nmod|END_ENTITY	The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant_glioma cells to induction of cell death .
16642033	0	Bcl-2	0,5	Bax	38,41	Bcl-2	Bax	596	581	Gene	Gene	changes|amod|START_ENTITY conformation|nsubj|changes conformation|xcomp|inhibit inhibit|dobj|oligomerization oligomerization|compound|END_ENTITY	Bcl-2 changes conformation to inhibit Bax oligomerization .
16721734	0	Bcl-2	70,75	Bax	63,66	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	extract|xcomp|START_ENTITY extract|dobj|END_ENTITY	Immunohistological evidences of Ginkgo_biloba extract altering Bax to Bcl-2 expression ratio in the hippocampus and motor cortex of senescence accelerated mice .
16888403	0	Bcl-2	51,56	Bax	57,60	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Inhalation of low-level formaldehyde increases the Bcl-2 / Bax expression ratio in the hippocampus of immunologically sensitized mice .
16906335	0	Bcl-2	136,141	Bax	142,145	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Diazoxide preconditioning alleviates apoptosis of hippocampal neurons induced by anoxia-reoxygenation in vitro through up-regulation of Bcl-2 / Bax protein ratio .
17005564	0	Bcl-2	59,64	Bax	87,90	Bcl-2	Bax	596	581	Gene	Gene	alteration|nmod|START_ENTITY elicits|dobj|alteration elicits|dep|inhibits inhibits|dobj|formation formation|compound|END_ENTITY	tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation .
17053028	0	Bcl-2	88,93	Bax	94,97	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	apoptosis|nmod|START_ENTITY inhibiting|nmod|apoptosis inhibiting|dep|rate rate|compound|END_ENTITY	Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2 / Bax rate and p38-beta mitogen-activated protein kinase .
17076657	0	Bcl-2	130,135	Bax	136,139	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	levels|nummod|START_ENTITY levels|compound|END_ENTITY	Recombinant human granulocyte_colony-stimulating_factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2 / Bax expression levels .
17081372	0	Bcl-2	81,86	Bax	87,90	Bcl-2	Bax	596	581	Gene	Gene	associated|nmod|START_ENTITY cells|acl:relcl|associated induced|dobj|cells C-reactive_protein|acl|induced C-reactive_protein|parataxis|-RSB- -RSB-|nsubj|changes changes|compound|END_ENTITY	-LSB- C-reactive_protein induced human endothelium cells apoptosis is associated with Bcl-2 / Bax gene expression changes -RSB- .
17331788	0	Bcl-2	173,178	Bax	45,48	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY suberoylanilide_hydroxamic_acid|nmod|expression induced|nmod|suberoylanilide_hydroxamic_acid apoptosis|acl|induced activation|nmod|apoptosis activation|compound|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
17369104	0	Bcl-2	120,125	Bax	126,129	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	D-beta-hydroxybutyrate inhibits the apoptosis of PC12 cells induced by 6-OHDA in relation to up-regulating the ratio of Bcl-2 / Bax mRNA .
17386268	0	Bcl-2	40,45	Bax	92,95	Bcl-2	Bax	596	581	Gene	Gene	mimic|nmod|START_ENTITY mimic|dep|role role|nmod|END_ENTITY	A structural viral mimic of prosurvival Bcl-2 : a pivotal role for sequestering proapoptotic Bax and Bak .
17408077	0	Bcl-2	0,5	Bax	6,9	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Bcl-2 / Bax ratio , mitochondrial membranes and aerobic enzyme activity in cardiomyocytes of rats after submaximal training .
17431754	0	Bcl-2	5,10	Bax	11,14	Bcl-2	Bax	596	581	Gene	Gene	START_ENTITY|parataxis|protects protects|nsubj|ratio ratio|compound|END_ENTITY	High Bcl-2 / Bax ratio in Walker_tumor cells protects mitochondria but does not prevent H2O2-induced apoptosis via calcineurin pathways .
17577309	0	Bcl-2	102,107	Bax	108,111	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Matrine induces apoptosis in angiotensin_II-stimulated hyperplasia of cardiac fibroblasts : effects on Bcl-2 / Bax expression and caspase-3 activation .
17577445	0	Bcl-2	87,92	Bax	94,97	Bcl-2	Bax	596	581	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|protein protein|compound|END_ENTITY	-LSB- Effects of nerve_growth_factor pretreatment on apoptosis of neurons and expression of Bcl-2 , Bax protein in brain tissue following cerebral_ischemia / reperfusion injury in gerbils -RSB- .
17639989	0	Bcl-2	108,113	Bax	98,101	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	level|compound|START_ENTITY mRNA|appos|level mRNA|compound|END_ENTITY	-LSB- Effects of TX0201 abstracted from heart-regulating formula on spatial learning and regulation of Bax mRNA , Bcl-2 mRNA level in brain of rat with Alzheimer 's _ disease -RSB- .
17880809	0	Bcl-2	70,75	Bax	41,44	Bcl-2	Bax	596	581	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|proapoptotic proapoptotic|dep|END_ENTITY	-LSB- Analysis of intracellular proapoptotic -LRB- Bax , Bak -RRB- and antiapoptotic -LRB- Bcl-2 , Bcl-XL -RRB- proteins expression in thyrocytes from young patients with immune and non-immune thyroid_disorders -RSB- .
18178565	0	Bcl-2	57,62	Bax	27,30	Bcl-2	Bax	596	581	Gene	Gene	proteins|compound|START_ENTITY regulation|nmod|proteins regulation|nmod|END_ENTITY	Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1 .
18604733	0	Bcl-2	47,52	Bax	54,57	Bcl-2	Bax	596	581	Gene	Gene	p53|compound|START_ENTITY p53|dep|END_ENTITY	Apoptosis and proliferation related molecules -LRB- Bcl-2 , Bax , p53 , PCNA -RRB- in papillary_microcarcinoma versus papillary_carcinoma of the thyroid .
18620728	0	Bcl-2	107,112	Bax	113,116	Bcl-2	Bax	596	581	Gene	Gene	affecting|dobj|START_ENTITY participates|advcl|affecting balance|parataxis|participates balance|nsubj|END_ENTITY	Deleted_in_pancreatic_carcinoma_locus_4 / Smad4 participates in the regulation of apoptosis by affecting the Bcl-2 / Bax balance in non-small cell lung_cancer .
18692524	0	Bcl-2	84,89	Bax	90,93	Bcl-2	Bax	596	581	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	CXCL12/CXCR4 signaling promotes human thymic dendritic cell survival regulating the Bcl-2 / Bax ratio .
18981409	0	Bcl-2	40,45	Bax	71,74	Bcl-2	Bax	596	581	Gene	Gene	proteins|compound|START_ENTITY restrain|nsubj|proteins restrain|dobj|END_ENTITY	Apoptosis is triggered when prosurvival Bcl-2 proteins can not restrain Bax .
19086645	0	Bcl-2	106,111	Bax	112,115	Bcl-2	Bax	596	581	Gene	Gene	/|compound|START_ENTITY regulating|dobj|/ induces|advcl|regulating induces|nsubj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Curcumin inhibits growth , induces G1_arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2 / Bax -RSB- .
19360319	0	Bcl-2	42,47	Bax	37,40	Bcl-2	Bax	596	581	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
19424680	0	Bcl-2	119,124	Bax	126,129	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Safflor_yellow_B suppresses pheochromocytoma cell -LRB- PC12 -RRB- injury induced by oxidative stress via antioxidant system and Bcl-2 / Bax pathway .
19813621	0	Bcl-2	59,64	Bax	4,7	Bcl-2	Bax	596	581	Gene	Gene	pore-forming|nmod:npmod|START_ENTITY inhibiting|dobj|pore-forming promotes|advcl|inhibiting promotes|nsubj|H2-H3 H2-H3|compound|END_ENTITY	The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2 's pore-forming and anti-Bax activities in the membrane .
19941892	0	Bcl-2	107,112	Bax	102,105	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax , Bcl-2 expression .
20148304	0	Bcl-2	72,77	Bax	49,52	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Effect of chronic lead exposure on pro-apoptotic Bax and anti-apoptotic Bcl-2 protein expression in rat hippocampus in vivo .
20948210	0	Bcl-2	102,107	Bax	108,111	Bcl-2	Bax	596	581	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Antitumor effects of ginkgolic_acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2 / Bax ratio to induce apoptosis .
21060756	0	Bcl-2	151,156	Bax	157,160	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	/|amod|START_ENTITY ratio|amod|/ ratio|compound|END_ENTITY	Time dependent bladder apoptosis induced by acute bladder_outlet_obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2 / Bax ratio .
21073944	0	Bcl-2	213,218	Bax	175,178	Bcl-2	Bax	596	581	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Progallin_A isolated from the acetic ether part of the leaves of Phyllanthus emblica L. induces apoptosis of human hepatocellular_carcinoma BEL-7404 cells by up-regulation of Bax expression and down-regulation of Bcl-2 expression .
21115120	0	Bcl-2	89,94	Bax	95,98	Bcl-2	Bax	596	581	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|compound|END_ENTITY	Selective impairment of CD4 + CD25 + Foxp3 + regulatory T cells by paclitaxel is explained by Bcl-2 / Bax mediated apoptosis .
21148306	0	Bcl-2	54,59	Bax	105,108	Bcl-2	Bax	596	581	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X -LRB- L -RRB- , Bcl-2 , and MCL-1 protein-protein interactions with Bax , Bak , Bad , or Bim and induces apoptosis in a Bax - and Bim-dependent manner .
21158042	0	Bcl-2	45,50	Bax	52,55	Bcl-2	Bax	596	581	Gene	Gene	expression|nmod|START_ENTITY Rb1|nmod|expression Effects|nmod|Rb1 Effects|appos|END_ENTITY	-LSB- Effects of Rb1 and Rg1 on the expression of Bcl-2 , Bax in apoptosis of HK-2 cells induced by the serum of kidney_ischemia / reperfusion -RSB- .
21242808	0	Bcl-2	103,108	Bax	96,99	Bcl-2	EPO	596	2056	Gene	Gene	proteins|compound|START_ENTITY reduces|nmod|proteins reduces|dobj|ratio ratio|nmod|END_ENTITY	Recombinant human erythropoietin suppresses endothelial cell apoptosis and reduces the ratio of Bax to Bcl-2 proteins in the aortas of apolipoprotein_E-deficient mice .
21472231	0	Bcl-2	116,121	Bax	149,152	Bcl-2	Bax	596	581	Gene	Gene	family|compound|START_ENTITY Immunoexpression|nmod|family apoptotic|dep|Immunoexpression apoptotic|appos|Bak Bak|dep|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21472231	0	Bcl-2	130,135	Bax	149,152	Bcl-2	Bax	596	581	Gene	Gene	Bak|compound|START_ENTITY Bak|dep|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21485723	0	Bcl-2	28,33	Bax	35,38	Bcl-2	Bax	596	581	Gene	Gene	caspase-3|compound|START_ENTITY caspase-3|dep|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
21545224	0	Bcl-2	138,143	Bax	144,147	Bcl-2	Bax	596	581	Gene	Gene	role|nmod|START_ENTITY effects|dep|role effects|dep|END_ENTITY	Anti-proliferative effects of organic extracts from root bark of Juglans Regia L. -LRB- RBJR -RRB- on MDA-MB-231 human breast_cancer cells : role of Bcl-2 / Bax , caspases and Tp53 .
21783889	0	Bcl-2	86,91	Bax	92,95	Bcl-2	Bax	596	581	Gene	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	Propolis induces cell cycle arrest and apoptosis in human leukemic U937 cells through Bcl-2 / Bax regulation .
21894749	0	Bcl-2	18,23	Bax	25,28	Bcl-2	Bax	596	581	Gene	Gene	p53|compound|START_ENTITY p53|dep|END_ENTITY	-LSB- Dynamic study of Bcl-2 , Bax , p53 , and ACE expression in CD34 + cells of peripheral blood and bone marrow in acute_leukemia patients in the course of induction chemotherapy -RSB- .
21935568	0	Bcl-2	117,122	Bax	123,126	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	The potent peptide antagonist to angiogenesis , C16Y , and cisplatin act synergistically in the down-regulation of the Bcl-2 / Bax ratio and the induction of apoptosis in human ovarian_cancer cells .
22013032	0	Bcl-2	27,32	Bax	65,68	Bcl-2	Bax	596	581	Gene	Gene	homologues|compound|START_ENTITY act|nsubj|homologues act|nmod|inhibitors inhibitors|compound|END_ENTITY	The vaccinia_virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors .
22886241	0	Bcl-2	30,35	Bax	36,39	Bcl-2	Bax	596	581	Gene	Gene	regulation|nmod|START_ENTITY regulation|parataxis|affects affects|nsubj|expression expression|compound|END_ENTITY	AP-2a-dependent regulation of Bcl-2 / Bax expression affects apoptosis in the trophoblast .
22917577	0	Bcl-2	116,121	Bax	142,145	Bcl-2	Bax	596	581	Gene	Gene	up-regulation|nmod|START_ENTITY cells|nmod|up-regulation apoptosis|nmod|cells apoptosis|nmod|END_ENTITY	Resistance to butyrate impairs bile_acid-induced apoptosis in human colon_adenocarcinoma cells via up-regulation of Bcl-2 and inactivation of Bax .
22926545	0	Bcl-2	50,55	Bax	56,59	Bcl-2	Bax	596	581	Gene	Gene	down-regulation|nmod|START_ENTITY apoptosis|nmod|down-regulation apoptosis|dep|END_ENTITY	Daidzein induced apoptosis via down-regulation of Bcl-2 / Bax and triggering of the mitochondrial pathway in BGC-823 cells .
23023341	0	Bcl-2	92,97	Bax	98,101	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY neurotoxicity|nmod|cells effect|nmod|neurotoxicity effect|parataxis|signal signal|nsubj|END_ENTITY	Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2 / Bax signal pathway .
23064052	0	Bcl-2	48,53	Bax	14,17	Bcl-2	Bax	596	581	Gene	Gene	mitochondrial|nmod|START_ENTITY mitochondrial|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x -LRB- L -RRB- : keep your friends close but your enemies closer .
23108993	0	Bcl-2	85,90	Bax	80,83	Bcl-2	Bax	100009447(Tax:9986)	100355675(Tax:9986)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
23154865	0	Bcl-2	38,43	Bax	31,34	Bcl-2	Bax	596	581	Gene	Gene	mutants|compound|START_ENTITY END_ENTITY|nmod|mutants	Enhanced heterodimerization of Bax by Bcl-2 mutants improves irradiated cell survival .
23245210	0	Bcl-2	109,114	Bax	115,118	Bcl-2	Bax	596	581	Gene	Gene	balance|amod|START_ENTITY balance|compound|END_ENTITY	Melatonin is involved in the apoptosis and necrosis of pancreatic_cancer cell line SW-1990 via modulating of Bcl-2 / Bax balance .
23297497	0	Bcl-2	109,114	Bax	115,118	Bcl-2	Bax	596	581	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Downregulation of PAR expression induces the apoptosis of human prostate_cancer PC3 cells and increases the Bcl-2 / Bax ratio -RSB- .
23365696	0	Bcl-2	76,81	Bax	82,85	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Exhaustive training increases uncoupling_protein_2 expression and decreases Bcl-2 / Bax ratio in rat skeletal muscle .
23451794	0	Bcl-2	125,130	Bax	131,134	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Flavanols from evening primrose -LRB- Oenothera paradoxa -RRB- defatted seeds inhibit prostate cells invasiveness and cause changes in Bcl-2 / Bax mRNA ratio .
23527236	0	Bcl-2	18,23	Bax	24,27	Bcl-2	Bax	596	581	Gene	Gene	Apoptosis|dep|START_ENTITY up-regulation|dep|Apoptosis up-regulation|amod|END_ENTITY	Apoptosis through Bcl-2 / Bax and cleaved caspase up-regulation in melanoma treated by boron neutron capture therapy .
23563626	0	Bcl-2	88,93	Bax	94,97	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Hydrogen-rich medium suppresses the generation of reactive oxygen species , elevates the Bcl-2 / Bax ratio and inhibits advanced glycation end product-induced apoptosis .
23626686	0	Bcl-2	37,42	Bax	157,160	Bcl-2	Bax	596	581	Gene	Gene	protein|compound|START_ENTITY Reconstitution|nmod|protein Reconstitution|nmod|protein protein|compound|END_ENTITY	Reconstitution of the anti-apoptotic Bcl-2 protein into lipid membranes and biophysical evidence for its detergent-driven association with the pro-apoptotic Bax protein .
23631820	0	Bcl-2	138,143	Bax	144,147	Bcl-2	Bax	596	581	Gene	Gene	balance|amod|START_ENTITY balance|compound|END_ENTITY	Annexin_A3 is associated with a poor prognosis in breast_cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2 / Bax balance .
23710741	12	Bcl-2	2417,2422	Bax	2423,2426	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	START_ENTITY|dep|B B|dep|END_ENTITY	Bax , Bcl-2 expression and apoptosis index of group B , C and D were significantly higher than that of group A -LRB- all P < 0.05 -RRB- , while Bcl-2 / Bax of group B , C and D were significantly lower than that of group A -LRB- all P < 0.05 -RRB- .
23991130	0	Bcl-2	152,157	Bax	158,161	Bcl-2	Bax	596	581	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MicroRNA-650 was a prognostic factor in human lung_adenocarcinoma and confers the docetaxel chemoresistance of lung_adenocarcinoma cells via regulating Bcl-2 / Bax expression .
24095822	0	Bcl-2	115,120	Bax	121,124	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor_impairment , redox balance and Bcl-2 / Bax expression in experimental Parkinson 's _ disease mice .
24633814	0	Bcl-2	76,81	Bax	82,85	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY cells|nmod|modulation apoptosis|nmod|cells Effects|nmod|apoptosis Effects|dep|END_ENTITY	Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2 / Bax and caspase-3 activation .
24677263	0	Bcl-2	61,66	Bax	67,70	Bcl-2	Bax	596	581	Gene	Gene	proteins|nummod|START_ENTITY proteins|compound|END_ENTITY	CDK1 switches mitotic_arrest to apoptosis by phosphorylating Bcl-2 / Bax family proteins during treatment with microtubule interfering agents .
24690773	0	Bcl-2	101,106	Bax	130,133	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	An-Gong-Niu-Huang Wan protects against cerebral_ischemia induced apoptosis in rats : up-regulation of Bcl-2 and down-regulation of Bax and caspase-3 .
24818492	0	Bcl-2	107,112	Bax	114,117	Bcl-2	Bax	100009447(Tax:9986)	100355675(Tax:9986)	Gene	Gene	Caspase-3|amod|START_ENTITY Caspase-3|amod|END_ENTITY	-LSB- Effects of acupotomy , electroacupuncture or round-sharp acupuncture needle interventions on expression of Bcl-2 , Bax , Caspase-3 proteins of rectus femoris in rabbits with knee ostarthritis -RSB- .
24819963	0	Bcl-2	58,63	Bax	53,56	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
24880241	0	Bcl-2	0,5	Bax	6,9	Bcl-2	Bax	101833785	101842912	Gene	Gene	START_ENTITY|dep|Tend Tend|compound|END_ENTITY	Bcl-2 / Bax Expression Levels Tend to Influence AMPAergic Trafficking Mechanisms During Hibernation in Mesocricetus_auratus .
24912196	0	Bcl-2	12,17	Bax	81,84	Bcl-2	Bax	596	581	Gene	Gene	members|compound|START_ENTITY affect|nsubj|members affect|advcl|inhibiting inhibiting|dobj|END_ENTITY	Prosurvival Bcl-2 family members affect autophagy only indirectly , by inhibiting Bax and Bak .
25108507	0	Bcl-2	111,116	Bax	117,120	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Significance of apoptosis related proteins on malignant transformation of ovarian_tumors : A comparison between Bcl-2 / Bax ratio and p53 immunoreactivity .
25187829	0	Bcl-2	84,89	Bax	90,93	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Emodin inhibits LOVO colorectal_cancer cell proliferation via the regulation of the Bcl-2 / Bax ratio and cytochrome_c .
25374178	0	Bcl-2	13,18	Bax	19,22	Bcl-2	Bax	596	581	Gene	Gene	Roles|nmod|START_ENTITY Roles|dep|END_ENTITY	Roles of the Bcl-2 / Bax ratio , caspase-8 and 9 in resistance of breast_cancer cells to paclitaxel .
25471003	0	Bcl-2	70,75	Bax	77,80	Bcl-2	Bax	596	581	Gene	Gene	survivin|compound|START_ENTITY survivin|dep|END_ENTITY	Changes in the expression pattern of apoptotic molecules -LRB- galectin-3 , Bcl-2 , Bax , survivin -RRB- during progression of thyroid_malignancy and their clinical significance .
25489228	0	Bcl-2	93,98	Bax	99,102	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	increasing|iobj|START_ENTITY increasing|dobj|END_ENTITY	Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2 / Bax and Bcl-xL/Bax ratios and reducing reactive gliosis .
25556484	0	Bcl-2	145,150	Bax	105,108	Bcl-2	Bax	596	581	Gene	Gene	FasL|nmod|START_ENTITY Apoptosis|dep|FasL Apoptosis|nmod|END_ENTITY	b-elemene Induces Caspase-dependent Apoptosis in Human_Glioma Cells in vitro through the Upregulation of Bax and Fas / FasL and Downregulation of Bcl-2 .
25582208	0	Bcl-2	34,39	Bax	40,43	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|expression expression|compound|END_ENTITY	-LSB- Effect of simvastatin on retinal Bcl-2 / Bax expression and cell apoptosis in rats with ischemia-reperfusion injury -RSB- .
25775423	0	Bcl-2	102,107	Bax	108,111	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Acetylated Chitosan Oligosaccharides Act as Antagonists against Glutamate-Induced PC12 Cell Death via Bcl-2 / Bax Signal Pathway .
25857445	0	Bcl-2	54,59	Bax	50,53	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	MicroRNA-29a induces apoptosis via increasing the Bax : Bcl-2 ratio in dermal fibroblasts of patients with systemic_sclerosis .
25867342	0	Bcl-2	47,52	Bax	53,56	Bcl-2	Bax	596	581	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of TIEG1 on apoptosis and expression of Bcl-2 / Bax and Pten in leukemic cell lines .
25975837	0	Bcl-2	121,126	Bax	112,115	Bcl-2	Bax	596	581	Gene	Gene	bortezomib|nmod|START_ENTITY bortezomib|nmod|upregulation upregulation|nmod|END_ENTITY	ALK-negative anaplastic_large_cell_lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2 .
26281601	0	Bcl-2	60,65	Bax	66,69	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	cisplatin|nmod|START_ENTITY Effects|nmod|cisplatin Effects|parataxis|subcutaneous subcutaneous|nsubj|expression expression|compound|END_ENTITY	-LSB- Effects of compound Daqiqi decoction combined cisplatin on Bcl-2 / Bax expression of nude_mice ovarian_cancer subcutaneous transplanted_tumor -RSB- .
26281601	0	Bcl-2	60,65	Bax	66,69	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	cisplatin|nmod|START_ENTITY Effects|nmod|cisplatin Effects|parataxis|subcutaneous subcutaneous|nsubj|expression expression|compound|END_ENTITY	-LSB- Effects of compound Daqiqi decoction combined cisplatin on Bcl-2 / Bax expression of nude_mice ovarian_cancer subcutaneous transplanted_tumor -RSB- .
26387182	0	Bcl-2	37,42	Bax	43,46	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	alterations|nmod|START_ENTITY -LSB-|dobj|alterations END_ENTITY|dep|-LSB-	-LSB- The alterations of apoptosis factor Bcl-2 / Bax in the early Parkinson 's _ disease rats and the protective effect of scorpion venom derived activity peptide -RSB- .
26387182	0	Bcl-2	37,42	Bax	43,46	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	alterations|nmod|START_ENTITY -LSB-|dobj|alterations END_ENTITY|dep|-LSB-	-LSB- The alterations of apoptosis factor Bcl-2 / Bax in the early Parkinson 's _ disease rats and the protective effect of scorpion venom derived activity peptide -RSB- .
26491047	0	Bcl-2	66,71	Bax	72,75	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	ATP promotes cell survival via regulation of cytosolic -LSB- Ca2 + -RSB- and Bcl-2 / Bax ratio in lung_cancer cells .
26679980	0	Bcl-2	72,77	Bax	101,104	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	Caspase-3|amod|START_ENTITY Caspase-3|dep|END_ENTITY	Subchronic exposure of benzo -LRB- a -RRB- pyrene interferes with the expression of Bcl-2 , Ki-67 , C-myc and p53 , Bax , Caspase-3 in sub-regions of cerebral cortex and hippocampus .
26813281	0	Bcl-2	73,78	Bax	79,82	Bcl-2	Bax	596	581	Gene	Gene	Effects|nmod|START_ENTITY Effects|parataxis|-RSB- -RSB-|nsubj|END_ENTITY	-LSB- Effects of emodin-8-O-b-D-glucoside on cell apoptosis and expression of Bcl-2 / Bax in cervical cancer SKOV3 cells -RSB- .
26900785	0	Bcl-2	44,49	Bax	50,53	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	START_ENTITY|dep|balance balance|compound|END_ENTITY	Lycopene modulates cholinergic dysfunction , Bcl-2 / Bax balance , and antioxidant enzymes gene transcripts in monosodium_glutamate -LRB- E621 -RRB- induced neurotoxicity in a rat model .
26939764	0	Bcl-2	113,118	Bax	119,122	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Dietary restriction suppresses apoptotic cell death , promotes Bcl-2 and Bcl-xl mRNA expression and increases the Bcl-2 / Bax protein ratio in the rat cortex after cortical_injury .
27053609	0	Bcl-2	60,65	Bax	19,22	Bcl-2	Bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	caspase-3|nmod|START_ENTITY caspase-3|dep|END_ENTITY	-LSB- Up-regulations of Bax and caspase-3 and down-regulation of Bcl-2 after Xinfeng capsule treatment in adjuvant-induced_arthritis rats -RSB- .
7644501	0	Bcl-2	9,14	Bax	71,74	Bcl-2	Bax	596	581	Gene	Gene	members|compound|START_ENTITY demonstrate|nsubj|members demonstrate|nmod|END_ENTITY	Multiple Bcl-2 family members demonstrate selective dimerizations with Bax .
7992838	0	Bcl-2	90,95	Bax	61,64	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY determination|appos|inhibitor determination|nmod|distribution distribution|nmod|END_ENTITY	Immunohistochemical determination of in vivo distribution of Bax , a dominant inhibitor of Bcl-2 .
8183370	0	Bcl-2	23,28	Bax	98,101	Bcl-2	Bax	596	581	Gene	Gene	domains|nmod|START_ENTITY required|nsubjpass|domains required|nmod|END_ENTITY	BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax .
8358790	0	Bcl-2	0,5	Bax	56,59	Bcl-2	Bax	596	581	Gene	Gene	heterodimerizes|nsubj|START_ENTITY heterodimerizes|nmod|homolog homolog|appos|END_ENTITY	Bcl-2 heterodimerizes in vivo with a conserved homolog , Bax , that accelerates programmed cell death .
8621473	0	Bcl-2	42,47	Bax	24,27	Bcl-2	Bax	596	581	Gene	Gene	converts|dobj|START_ENTITY END_ENTITY|acl:relcl|converts	A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis .
8631771	0	Bcl-2	46,51	Bax	21,24	Bcl-2	Bax	596	581	Gene	Gene	heterodimerizes|nmod|START_ENTITY heterodimerizes|nsubj|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
8631771	0	Bcl-2	46,51	Bax	75,78	Bcl-2	Bax	596	581	Gene	Gene	heterodimerizes|nmod|START_ENTITY heterodimerizes|nmod|END_ENTITY	Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain -LRB- BH3 -RRB- distinct from BH1 and BH2 .
8777167	0	Bcl-2	33,38	Bax	14,17	Bcl-2	Bax	596	581	Gene	Gene	relation|nmod|START_ENTITY Expression|nmod|relation Expression|nmod|END_ENTITY	Expression of Bax in relation to Bcl-2 and other predictive parameters in breast_cancer .
9058596	0	Bcl-2	31,36	Bax	37,40	Bcl-2	Bax	596	581	Gene	Gene	decreases|dobj|START_ENTITY ratio|dep|decreases ratio|compound|END_ENTITY	6-Mercaptopurine decreases the Bcl-2 / Bax ratio and induces apoptosis in activated splenic B lymphocytes .
9108402	0	Bcl-2	27,32	Bax	33,36	Bcl-2	Bax	596	581	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	CD6 ligation modulates the Bcl-2 / Bax ratio and protects chronic_lymphocytic_leukemia B cells from apoptosis induced by anti-IgM .
9202007	0	Bcl-2	57,62	Bax	73,76	Bcl-2	Bax	596	581	Gene	Gene	complementation|nmod|START_ENTITY mutant|nsubj|complementation mutant|nmod|truncation truncation|compound|END_ENTITY	Structural and functional complementation of an inactive Bcl-2 mutant by Bax truncation .
9219694	0	Bcl-2	46,51	Bax	14,17	Bcl-2	Bax	596	581	Gene	Gene	channel-forming|nmod|START_ENTITY channel-forming|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of Bax channel-forming activity by Bcl-2 .
9361016	0	Bcl-2	0,5	Bax	28,31	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	counters|amod|START_ENTITY apoptosis|nsubj|counters apoptosis|nmod|heterodimerization-dependent heterodimerization-dependent|compound|END_ENTITY	Bcl-2 counters apoptosis by Bax heterodimerization-dependent and - independent mechanisms in the T-cell lineage .
9362442	0	Bcl-2	98,103	Bax	54,57	Bcl-2	Bax	596	581	Gene	Gene	effects|nmod|START_ENTITY apoptosis|dep|effects apoptosis|nmod|cells cells|acl|induced induced|nmod|overexpression overexpression|compound|END_ENTITY	Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression : differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis .
9389564	0	Bcl-2	49,54	Bax	14,17	Bcl-2	Bax	596	581	Gene	Gene	family|compound|START_ENTITY member|nmod|family Expression|appos|member Expression|nmod|END_ENTITY	Expression of Bax , a pro-apoptotic member of the Bcl-2 family , in esophageal_squamous_cell_carcinoma .
9432028	0	Bcl-2	15,20	Bax	21,24	Bcl-2	Bax	596	581	Gene	Gene	Alterations|dep|START_ENTITY levels|dep|Alterations levels|compound|END_ENTITY	Alterations in Bcl-2 / Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis .
9517506	0	Bcl-2	9,14	Bax	15,18	Bcl-2	Bax	596	581	Gene	Gene	START_ENTITY|parataxis|feature feature|nsubj|END_ENTITY	Elevated Bcl-2 / Bax are a consistent feature of apoptosis resistance in B-cell_chronic_lymphocytic_leukaemia and are correlated with in vivo chemoresistance .
9610364	0	Bcl-2	96,101	Bax	102,105	Bcl-2	Bax	596	581	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Zinc suppresses apoptosis of U937 cells induced by hydrogen_peroxide through an increase of the Bcl-2 / Bax ratio .
9695020	1	Bcl-2	23,28	Bax	44,47	Bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	The pro-apoptotic Bcl-2 family member , Bax .
9714690	0	Bcl-2	0,5	Bax	106,109	Bcl-2	Bax	596	581	Gene	Gene	expression|amod|START_ENTITY expression|dep|involvement involvement|nmod|END_ENTITY	Bcl-2 family expression in salivary glands from patients with primary Sj gren 's _ syndrome : involvement of Bax in salivary gland destruction .
9802058	0	Bcl-2	97,102	Bax	0,3	Bcl-2	Bax	596	581	Gene	Gene	expression|compound|START_ENTITY independent|nmod|expression status|amod|independent determinant|nmod|status determinant|nsubj|END_ENTITY	Bax is an important determinant of chemosensitivity in pediatric_tumor cell lines independent of Bcl-2 expression and p53 status .
9885381	0	Bcl-2	32,37	Bax	39,42	Bcl-2	Bax	596	581	Gene	Gene	Bcl-X|compound|START_ENTITY Bcl-X|dep|END_ENTITY	Immunohistochemical analysis of Bcl-2 , Bax , Bcl-X , and Mcl-1 expression in pancreatic_cancers .
11726273	0	Bcl-2	27,32	Bcl-2	94,99	Bcl-2	Bcl-2	596	596	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|parataxis|triggered triggered|nmod|phosphorylation phosphorylation|nmod|serine serine|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
11726273	0	Bcl-2	94,99	Bcl-2	27,32	Bcl-2	Bcl-2	596	596	Gene	Gene	serine|nmod|START_ENTITY phosphorylation|nmod|serine triggered|nmod|phosphorylation Dissociation|parataxis|triggered Dissociation|nmod|END_ENTITY	Dissociation of Bax from a Bcl-2 / Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2 .
17041564	0	Bcl-2	48,53	Bcl-2	75,80	Bcl-2	Bcl-2	596	596	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy .
17041564	0	Bcl-2	75,80	Bcl-2	48,53	Bcl-2	Bcl-2	596	596	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Antisense and nonantisense effects of antisense Bcl-2 on multiple roles of Bcl-2 as a chemosensitizer in cancer therapy .
11278245	0	Bcl-2	15,20	Bcl-B	0,5	Bcl-2	Bcl-B	596	10017	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Bcl-B , a novel Bcl-2 family member that differentially binds and regulates Bax and Bak .
10537354	0	Bcl-2	0,5	Bcl-X	7,12	Bcl-2	Bcl-X	596	598	Gene	Gene	expression|advmod|START_ENTITY expression|nsubj|END_ENTITY	Bcl-2 , Bcl-X , Bax , and Bak expression in short - and long-lived patients with diffuse large B-cell_lymphomas .
10597302	0	Bcl-2	142,147	Bcl-XL	148,154	Bcl-2	Bcl-XL	596	598	Gene	Gene	regulated|nmod|START_ENTITY pathways|acl:relcl|regulated Induction|nmod|pathways END_ENTITY|dep|Induction	Induction of apoptosis in U937 human leukemia cells by suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- proceeds through pathways that are regulated by Bcl-2 / Bcl-XL , c-Jun , and p21CIP1 , but independent of p53 .
15570009	0	Bcl-2	27,32	Bcl-XL	89,95	Bcl-2	Bcl-XL	596	598	Gene	Gene	expression|compound|START_ENTITY Trastuzumab|dobj|expression Trastuzumab|nmod|Bcl-2 Bcl-2|dep|oligonucleotides oligonucleotides|amod|END_ENTITY	Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2 / Bcl-XL bispecific antisense oligonucleotides in HER-2 gene -- amplified breast_cancer cells .
15570009	0	Bcl-2	83,88	Bcl-XL	89,95	Bcl-2	Bcl-XL	596	598	Gene	Gene	START_ENTITY|dep|oligonucleotides oligonucleotides|amod|END_ENTITY	Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2 / Bcl-XL bispecific antisense oligonucleotides in HER-2 gene -- amplified breast_cancer cells .
16928273	0	Bcl-2	73,78	Bcl-XL	0,6	Bcl-2	Bcl-XL	596	598	Gene	Gene	different|nmod|START_ENTITY different|nsubj|END_ENTITY	Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast_cancer cell line .
17173063	0	Bcl-2	108,113	Bcl-XL	114,120	Bcl-2	Bcl-XL	596	598	Gene	Gene	ABT-737|compound|START_ENTITY ABT-737|compound|END_ENTITY	` Seed ' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2 / Bcl-XL inhibitor ABT-737 .
17384650	0	Bcl-2	87,92	Bcl-XL	7,13	Bcl-2	Bcl-XL	596	598	Gene	Gene	levels|compound|START_ENTITY decrease|nsubj|levels associated|advcl|decrease associated|nsubjpass|END_ENTITY	Mcl-1 , Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2 , AP-2 and MITF levels decrease during progression of melanoma .
18056200	0	Bcl-2	4,9	Bcl-XL	10,16	Bcl-2	Bcl-XL	596	598	Gene	Gene	START_ENTITY|parataxis|sensitizes sensitizes|nsubj|ABT-737 ABT-737|amod|END_ENTITY	The Bcl-2 / Bcl-XL family inhibitor ABT-737 sensitizes ovarian_cancer cells to carboplatin .
21955141	0	Bcl-2	4,9	Bcl-XL	10,16	Bcl-2	Bcl-XL	596	598	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|ABT-737 ABT-737|amod|END_ENTITY	The Bcl-2 / Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma_cancer cells .
22002102	0	Bcl-2	102,107	Bcl-XL	108,114	Bcl-2	Bcl-XL	596	598	Gene	Gene	/|amod|START_ENTITY ABT-737|amod|/ ABT-737|amod|END_ENTITY	p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2 / Bcl-XL inhibitor ABT-737 .
23798675	0	Bcl-2	107,112	Bcl-XL	128,134	Bcl-2	Bcl-XL	596	598	Gene	Gene	members|amod|START_ENTITY regulation|nmod|members cells|nmod|regulation apoptosis|nmod|cells END_ENTITY|nsubj|apoptosis	CXCR4 chemokine receptor signaling induces apoptosis in acute_myeloid_leukemia cells via regulation of the Bcl-2 family members Bcl-XL , Noxa , and Bak .
24454684	0	Bcl-2	10,15	Bcl-XL	16,22	Bcl-2	Bcl-XL	596	598	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Targeting Bcl-2 / Bcl-XL induces antitumor activity in uveal_melanoma patient-derived xenografts .
24616095	0	Bcl-2	69,74	Bcl-XL	43,49	Bcl-2	Bcl-XL	596	598	Gene	Gene	region|compound|START_ENTITY binds|dobj|region binds|nsubj|protein protein|amod|END_ENTITY	After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization .
25726913	0	Bcl-2	105,110	Bcl-XL	111,117	Bcl-2	Bcl-XL	596	598	Gene	Gene	/|amod|START_ENTITY expression|amod|/ expression|amod|END_ENTITY	Lewis y enhances CAM-DR in ovarian_cancer cells by activating the FAK signaling pathway and upregulating Bcl-2 / Bcl-XL expression .
11262395	0	Bcl-2	19,24	Bcl-rambo	0,9	Bcl-2	Bcl-rambo	596	23786	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Bcl-rambo , a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension .
10679744	0	Bcl-2	0,5	Bcl-x	22,27	Bcl-2	Bcl-x	596	598	Gene	Gene	START_ENTITY|dep|ratios ratios|amod|END_ENTITY	Bcl-2 : bax and bcl-2 : Bcl-x ratios by image cytometric quantitation of immunohistochemical expression in ovarian_carcinoma : correlation with prognosis .
21472231	0	Bcl-2	116,121	Bcl-x	137,142	Bcl-2	Bcl-x	596	598	Gene	Gene	family|compound|START_ENTITY Immunoexpression|nmod|family apoptotic|dep|Immunoexpression apoptotic|appos|Bak Bak|dep|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21472231	0	Bcl-2	130,135	Bcl-x	137,142	Bcl-2	Bcl-x	596	598	Gene	Gene	Bak|compound|START_ENTITY Bak|dep|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
9317114	0	Bcl-2	134,139	Bcl-x	140,145	Bcl-2	Bcl-x	596	598	Gene	Gene	/|amod|START_ENTITY expression|amod|/ expression|amod|END_ENTITY	B cell receptor cross-linking prevents Fas-induced cell death by inactivating the IL-1_beta-converting_enzyme protease and regulating Bcl-2 / Bcl-x expression .
12046686	0	Bcl-2	0,5	Bcl-xL	7,13	Bcl-2	Bcl-xL	596	598	Gene	Gene	regulate|advmod|START_ENTITY regulate|nsubj|END_ENTITY	Bcl-2 , Bcl-xL and c-FLIP -LRB- L -RRB- potentially regulate the susceptibility of human peripheral blood monocyte-derived dendritic cells to cell death at different developmental stages .
17331788	0	Bcl-2	173,178	Bcl-xL	179,185	Bcl-2	Bcl-xL	24224(Tax:10116)	24888(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
18006518	0	Bcl-2	98,103	Bcl-xL	0,6	Bcl-2	Bcl-xL	596	598	Gene	Gene	proteins|compound|START_ENTITY dimerization|nmod|proteins implications|nmod|dimerization forms|parataxis|implications forms|nsubj|END_ENTITY	Bcl-xL forms two distinct homodimers at non-ionic detergents : implications in the dimerization of Bcl-2 family proteins .
18698039	0	Bcl-2	53,58	Bcl-xL	59,65	Bcl-2	Bcl-xL	596	598	Gene	Gene	signals|nmod|START_ENTITY induction|nmod|signals induction|dep|modulation modulation|amod|END_ENTITY	Gefitinib induction of in vivo detectable signals by Bcl-2 / Bcl-xL modulation of inositol_trisphosphate_receptor_type_3 .
18758060	0	Bcl-2	74,79	Bcl-xL	113,119	Bcl-2	Bcl-xL	596	598	Gene	Gene	B-cell_lymphoma_2|appos|START_ENTITY action|nmod|B-cell_lymphoma_2 regulation|nmod|action regulation|appos|END_ENTITY	Differential regulation of the antiapoptotic action of B-cell_lymphoma_2 -LRB- Bcl-2 -RRB- and B-cell_lymphoma extra long -LRB- Bcl-xL -RRB- by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 1-involved pathway in neuroglioma cells .
19088028	0	Bcl-2	98,103	Bcl-xL	104,110	Bcl-2	Bcl-xL	596	598	Gene	Gene	expressing|nmod|START_ENTITY expressing|dep|inhibitor inhibitor|amod|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
19934311	0	Bcl-2	112,117	Bcl-xL	118,124	Bcl-2	Bcl-xL	596	598	Gene	Gene	upregulation|amod|START_ENTITY upregulation|compound|END_ENTITY	Disruption of sphingosine_1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2 / Bcl-xL upregulation .
21393385	0	Bcl-2	119,124	Bcl-xL	136,142	Bcl-2	Bcl-xL	596	598	Gene	Gene	family|compound|START_ENTITY protein|nmod|family bad|appos|protein regulation|nmod|bad reveals|dobj|regulation reveals|nmod|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21393385	0	Bcl-2	4,9	Bcl-xL	136,142	Bcl-2	Bcl-xL	596	598	Gene	Gene	domain|compound|START_ENTITY reveals|nsubj|domain reveals|nmod|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
22608393	0	Bcl-2	55,60	Bcl-xL	61,67	Bcl-2	Bcl-xL	596	598	Gene	Gene	Pyrazole|nmod|START_ENTITY /|nsubj|Pyrazole /|dobj|antagonists antagonists|amod|END_ENTITY	Pyrazole and pyrimidine_phenylacylsulfonamides as dual Bcl-2 / Bcl-xL antagonists .
22608961	0	Bcl-2	57,62	Bcl-xL	63,69	Bcl-2	Bcl-xL	596	598	Gene	Gene	series|nmod|START_ENTITY Identification|nmod|series /|nsubj|Identification /|dobj|antagonists antagonists|amod|END_ENTITY	Identification of a phenylacylsulfonamide series of dual Bcl-2 / Bcl-xL antagonists .
22747598	0	Bcl-2	33,38	Bcl-xL	39,45	Bcl-2	Bcl-xL	596	598	Gene	Gene	design|nmod|START_ENTITY design|dep|inhibitors inhibitors|amod|END_ENTITY	Structure-based design of potent Bcl-2 / Bcl-xL inhibitors with strong in vivo antitumor activity .
23375957	0	Bcl-2	4,9	Bcl-xL	10,16	Bcl-2	Bcl-xL	596	598	Gene	Gene	START_ENTITY|parataxis|affects affects|nsubj|BH3I-2 BH3I-2|amod|END_ENTITY	The Bcl-2 / Bcl-xL inhibitor BH3I-2 ' affects the dynamics and subcellular localization of sumoylated proteins .
23429261	0	Bcl-2	94,99	Bcl-xL	100,106	Bcl-2	Bcl-xL	596	598	Gene	Gene	effects|nmod|START_ENTITY ABT-737|dep|effects ABT-737|amod|END_ENTITY	pRb/E2F -1 - mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2 / Bcl-xL inhibitor ABT-737 .
23448298	0	Bcl-2	32,37	Bcl-xL	38,44	Bcl-2	Bcl-xL	596	598	Gene	Gene	/|nsubj|START_ENTITY /|dobj|inhibitor inhibitor|amod|END_ENTITY	A potent and highly efficacious Bcl-2 / Bcl-xL inhibitor .
23475955	0	Bcl-2	0,5	Bcl-xL	6,12	Bcl-2	Bcl-xL	596	598	Gene	Gene	START_ENTITY|parataxis|increases increases|nsubj|inhibition inhibition|compound|END_ENTITY	Bcl-2 / Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic_tumor models .
24058878	0	Bcl-2	26,31	Bcl-xL	32,38	Bcl-2	Bcl-xL	596	598	Gene	Gene	START_ENTITY|dep|antagonist antagonist|dep|END_ENTITY	ABT-737 , a small molecule Bcl-2 / Bcl-xL antagonist , increases antimitotic-mediated apoptosis in human prostate_cancer cells .
24881567	0	Bcl-2	36,41	Bcl-xL	42,48	Bcl-2	Bcl-xL	596	598	Gene	Gene	Towards|nmod|START_ENTITY Towards|parataxis|inhibitors inhibitors|nsubj|END_ENTITY	Towards the next generation of dual Bcl-2 / Bcl-xL inhibitors .
26008975	0	Bcl-2	23,28	Bcl-xL	29,35	Bcl-2	Bcl-xL	596	598	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|parataxis|overcomes overcomes|nsubj|END_ENTITY	Combined inhibition of Bcl-2 / Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo .
26474387	0	Bcl-2	29,34	Bcl-xL	35,41	Bcl-2	Bcl-xL	596	598	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|parataxis|inhibition inhibition|nsubj|END_ENTITY	TIC10/ONC201 synergizes with Bcl-2 / Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo .
26488112	8	Bcl-2	1266,1271	Bcl-xL	1272,1278	Bcl-2	Bcl-xL	596	598	Gene	Gene	combining|nmod|START_ENTITY combining|parataxis|ABT-263 ABT-263|dep|antagonists antagonists|amod|END_ENTITY	However , by combining SSA with the Bcl-2 / Bcl-xL antagonists ABT-263 or ABT-199 , we were able to overcome this pro-survival effect .
8603411	0	Bcl-2	129,134	Bcl-xL	138,144	Bcl-2	Bcl-xL	596	598	Gene	Gene	switched|nmod|START_ENTITY switched|nmod|END_ENTITY	Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL .
9881495	0	Bcl-2	70,75	Bcl-xL	28,34	Bcl-2	Bcl-xL	596	598	Gene	Gene	family|compound|START_ENTITY member|nmod|family member|nsubj|Apoptosis Apoptosis|acl|inhibiting inhibiting|dobj|END_ENTITY	Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal_cancer .
19066994	0	Bcl-2	37,42	Bcl-xl	43,49	Bcl-2	Bcl-xl	596	598	Gene	Gene	screening|nmod|START_ENTITY screening|dep|inhibitors inhibitors|amod|END_ENTITY	In-silico screening of new potential Bcl-2 / Bcl-xl inhibitors as apoptosis modulators .
11689480	0	Bcl-2	48,53	Bcl2-L-10	0,9	Bcl-2	Bcl2-L-10	596	10017	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Bcl2-L-10 , a novel anti-apoptotic member of the Bcl-2 family , blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway .
22431925	0	Bcl-2	12,17	Bcl2L12	88,95	Bcl-2	Bcl2L12	596	83596	Gene	Gene	proteins|compound|START_ENTITY role|nmod|proteins role|dep|END_ENTITY	The role of Bcl-2 family proteins in therapy responses of malignant astrocytic_gliomas : Bcl2L12 and beyond .
19318089	0	Bcl-2	59,64	Beclin-1	16,24	Bcl-2	Beclin-1	596	8678	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death .
19347031	0	Bcl-2	0,5	Beclin-1	21,29	Bcl-2	Beclin-1	596	8678	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function .
23436561	0	Bcl-2	63,68	Beclin-1	95,103	Bcl-2	Beclin-1	100774873	100762045	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|appos|END_ENTITY	Anti-cell death engineering of CHO cells : co-overexpression of Bcl-2 for apoptosis inhibition , Beclin-1 for autophagy induction .
25032846	0	Bcl-2	94,99	Beclin-1	80,88	Bcl-2	Beclin-1	596	8678	Gene	Gene	releasing|nmod|START_ENTITY releasing|dobj|END_ENTITY	CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2 .
19395874	0	Bcl-2	96,101	Beclin_1	19,27	Bcl-2	Beclin 1	596	8678	Gene	Gene	weakening|nmod|START_ENTITY promotes|advcl|weakening promotes|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Beclin_1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL .
19535901	0	Bcl-2	82,87	Beclin_1	12,20	Bcl-2	Beclin 1	596	8678	Gene	Gene	function|nmod|START_ENTITY suppress|dobj|function suppress|nsubj|END_ENTITY	Why does n't Beclin_1 , a BH3-only_protein , suppress the anti-apoptotic function of Bcl-2 ?
20090905	0	Bcl-2	84,89	Beclin_1	27,35	Bcl-2	Beclin 1	596	8678	Gene	Gene	dependence|nmod|START_ENTITY dependence|nmod|END_ENTITY	Differential dependence on Beclin_1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal_cancer cells .
22485198	0	Bcl-2	0,5	Beclin_1	6,14	Bcl-2	Beclin 1	596	8678	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	Bcl-2 : Beclin_1 complex : multiple , mechanisms regulating autophagy/apoptosis toggle switch .
22579788	0	Bcl-2	73,78	Beclin_1	79,87	Bcl-2	Beclin 1	596	8678	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2 / Beclin_1 interaction in human glioma U251 cells .
24326530	0	Bcl-2	71,76	Beclin_1	77,85	Bcl-2	Beclin 1	596	8678	Gene	Gene	death|nmod|START_ENTITY death|parataxis|complex-dependent complex-dependent|amod|END_ENTITY	1-Methyl-4-phenylpyridinium-induced cell death via autophagy through a Bcl-2 / Beclin_1 complex-dependent pathway .
25565814	0	Bcl-2	109,114	Beclin_1	100,108	Bcl-2	Beclin 1	596	8678	Gene	Gene	complex|dep|START_ENTITY complex|amod|END_ENTITY	Ferroferric_oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin_1 / Bcl-2 / VPS34 complex .
25631043	0	Bcl-2	171,176	Beclin_1	135,143	Bcl-2	Beclin 1	596	8678	Gene	Gene	Leucine-rich_Pentatricopeptide_Repeat-containing_Protein|dep|START_ENTITY Leucine-rich_Pentatricopeptide_Repeat-containing_Protein|nmod|END_ENTITY	The Viral Restriction Factor Tetherin Prevents Leucine-rich_Pentatricopeptide_Repeat-containing_Protein -LRB- LRPPRC -RRB- from Association with Beclin_1 and B-cell_CLL / lymphoma_2 -LRB- Bcl-2 -RRB- and Enhances Autophagy and Mitophagy .
12700646	0	Bcl-2	47,52	Bfk	0,3	Bcl-2	Bfk	596	440603	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	Bfk : a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region .
15086420	0	Bcl-2	4,9	Bfl-1	24,29	Bcl-2	Bfl-1	596	597	Gene	Gene	A1|amod|START_ENTITY A1|compound|END_ENTITY	The Bcl-2 family member Bfl-1 / A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells .
18812174	0	Bcl-2	53,58	Bfl-1	96,101	Bcl-2	Bfl-1	596	597	Gene	Gene	proteins|compound|START_ENTITY portrait|nmod|proteins portrait|dep|structure structure|nmod|END_ENTITY	Completing the family portrait of the anti-apoptotic Bcl-2 proteins : crystal structure of human Bfl-1 in complex with Bim .
7478596	0	Bcl-2	8,13	Bfl-1	28,33	Bcl-2	Bfl-1	596	597	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel Bcl-2 related gene , Bfl-1 , is overexpressed in stomach_cancer and preferentially expressed in bone marrow .
9671389	0	Bcl-2	34,39	Bfl-1	25,30	Bcl-2	Bfl-1	596	597	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Functional dissection of Bfl-1 , a Bcl-2 homolog : anti-apoptosis , oncogene-cooperation and cell proliferation activities .
11585909	0	Bcl-2	52,57	Bid	0,3	Bcl-2	Bid	596	637	Gene	Gene	family|compound|START_ENTITY protein|nmod|family END_ENTITY|appos|protein	Bid , a widely expressed proapoptotic protein of the Bcl-2 family , displays lipid transfer activity .
11154272	0	Bcl-2	50,55	Bim	18,21	Bcl-2	Bim	12043(Tax:10090)	12125(Tax:10090)	Gene	Gene	relative|nmod|START_ENTITY Downregulation|appos|relative Downregulation|nmod|END_ENTITY	Downregulation of Bim , a proapoptotic relative of Bcl-2 , is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors .
11210187	0	Bcl-2	83,88	Bim	98,101	Bcl-2	Bim	12043(Tax:10090)	12125(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Gene structure alternative splicing , and chromosomal localization of pro-apoptotic Bcl-2 relative Bim .
11734221	0	Bcl-2	104,109	Bim	70,73	Bcl-2	Bim	596	10018	Gene	Gene	family|compound|START_ENTITY member|nmod|family cloning|appos|member cloning|nmod|isoforms isoforms|nmod|END_ENTITY	Molecular cloning and characterization of six novel isoforms of human Bim , a member of the proapoptotic Bcl-2 family .
14970329	0	Bcl-2	28,33	Bim	56,59	Bcl-2	Bim	596	10018	Gene	Gene	member|compound|START_ENTITY expression|nmod|member Regulation|nmod|expression END_ENTITY|nsubj|Regulation	Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering .
16394656	0	Bcl-2	22,27	Bim	8,11	Bcl-2	Bim	12043(Tax:10090)	12125(Tax:10090)	Gene	Gene	members|compound|START_ENTITY members|compound|END_ENTITY	Role of Bim and other Bcl-2 family members in autoimmune and degenerative_diseases .
16780816	0	Bcl-2	34,39	Bim	55,58	Bcl-2	Bim	12043(Tax:10090)	12125(Tax:10090)	Gene	Gene	members|amod|START_ENTITY members|amod|END_ENTITY	Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia .
18812174	0	Bcl-2	53,58	Bim	118,121	Bcl-2	Bim	596	10018	Gene	Gene	proteins|compound|START_ENTITY portrait|nmod|proteins Completing|dobj|portrait Completing|nmod|END_ENTITY	Completing the family portrait of the anti-apoptotic Bcl-2 proteins : crystal structure of human Bfl-1 in complex with Bim .
19950021	0	Bcl-2	38,43	Bim	59,62	Bcl-2	Bim	12043(Tax:10090)	12125(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3 .
21451108	0	Bcl-2	0,5	Bim	79,82	Bcl-2	Bim	596	10018	Gene	Gene	allows|nsubj|START_ENTITY allows|xcomp|tolerate tolerate|dobj|expression expression|nmod|END_ENTITY	Bcl-2 allows effector and memory CD8 + T cells to tolerate higher expression of Bim .
22065578	0	Bcl-2	108,113	Bim	52,55	Bcl-2	Bim	12043(Tax:10090)	12125(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY protein|acl:relcl|interacts protein|compound|END_ENTITY	Natural diterpenoid compound elevates expression of Bim protein , which interacts with antiapoptotic protein Bcl-2 , converting it to proapoptotic Bax-like molecule .
23235460	0	Bcl-2	92,97	Bim	50,53	Bcl-2	Bim	596	10018	Gene	Gene	antagonist|amod|START_ENTITY END_ENTITY|nmod|antagonist	The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist .
9430630	0	Bcl-2	27,32	Bim	0,3	Bcl-2	Bim	596	10018	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	Bim : a novel member of the Bcl-2 family that promotes apoptosis .
12853472	0	Bcl-2	20,25	Buffy	0,5	Bcl-2	Buffy	53585(Tax:7227)	36251(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Buffy , a Drosophila Bcl-2 protein , has anti-apoptotic and cell cycle inhibitory functions .
12532785	0	Bcl-2	205,210	C-myc	113,118	Bcl-2	C-myc	596	4609	Gene	Gene	-RSB-|compound|START_ENTITY high-expression|nmod|-RSB- adenovirus|nmod|high-expression adenovirus|nmod|END_ENTITY	-LSB- In vitro and in vivo studies on the biologic effects and molecular mechanism of recombinant RA538 and antisense C-myc adenovirus on human gastric , esophageal and cancer cell lines with high-expression of Bcl-2 gene -RSB- .
12970736	0	Bcl-2	14,19	C/EBP	34,39	Bcl-2	C/EBP	596	1050	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of Bcl-2 expression by C/EBP in t -LRB- 14 ; 18 -RRB- lymphoma cells .
11278725	0	Bcl-2	76,81	CD120a	54,60	Bcl-2	CD120a	596	7132	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Phosphorylation of the tumor necrosis factor receptor CD120a -LRB- p55 -RRB- recruits Bcl-2 and protects against apoptosis .
20650803	0	Bcl-2	77,82	CD147	20,25	Bcl-2	CD147	596	682	Gene	Gene	-RSB-|compound|START_ENTITY induces|nmod|-RSB- induces|nsubj|Down-regulation Down-regulation|nmod|expression expression|compound|END_ENTITY	-LSB- Down-regulation of CD147 expression induces SiHa cell apoptosis through the Bcl-2 pathway -RSB- .
25996258	0	Bcl-2	16,21	CD147	25,30	Bcl-2	CD147	596	682	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis .
10456672	0	Bcl-2	91,96	CD34	124,128	Bcl-2	CD34	596	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Effect of all-trans_retinoic_acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid_leukaemia CD34 positive cells .
11380462	0	Bcl-2	0,5	CD34	34,38	Bcl-2	CD34	596	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Bcl-2 and Bcl-x expression in the CD34 + cells of aplastic_anaemia patients : relationship with increased apoptosis and upregulation of Fas_antigen .
11532351	0	Bcl-2	94,99	CD34	56,60	Bcl-2	CD34	596	947	Gene	Gene	express|dobj|START_ENTITY cells|acl:relcl|express apoptosis|dep|cells apoptosis|nmod|CD38 CD38|compound|END_ENTITY	Transforming_growth_factor-beta -LRB- 1 -RRB- induces apoptosis in CD34 -LRB- + -RRB- CD38 -LRB- - / low -RRB- cells that express Bcl-2 at a low level .
21595920	0	Bcl-2	31,36	CD34	87,91	Bcl-2	CD34	596	947	Gene	Gene	expression|nmod|START_ENTITY reduces|dobj|expression reduces|advcl|leading leading|nmod|apoptosis apoptosis|nmod|lines lines|compound|END_ENTITY	Curcumin reduces expression of Bcl-2 , leading to apoptosis in daunorubicin-insensitive CD34 + acute_myeloid_leukemia cell lines and primary sorted CD34 + acute_myeloid_leukemia cells .
21894749	0	Bcl-2	18,23	CD34	57,61	Bcl-2	CD34	596	947	Gene	Gene	p53|compound|START_ENTITY study|nmod|p53 study|nmod|cells cells|nummod|END_ENTITY	-LSB- Dynamic study of Bcl-2 , Bax , p53 , and ACE expression in CD34 + cells of peripheral blood and bone marrow in acute_leukemia patients in the course of induction chemotherapy -RSB- .
26431162	0	Bcl-2	92,97	CD34	112,116	Bcl-2	CD34	596	947	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|inhibition inhibition|nmod|proliferating proliferating|compound|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
26960457	0	Bcl-2	30,35	CD34	24,28	Bcl-2	CD34	596	947	Gene	Gene	Ki-67|appos|START_ENTITY Ki-67|appos|END_ENTITY	The role of Ki-67 , p16 , CD34 , Bcl-2 , cyclooxygenase-2 in the pathogenesis of proliferative_verrucous_leukoplakia .
8839847	0	Bcl-2	25,30	CD34	72,76	Bcl-2	CD34	596	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Interleukin-10 increases Bcl-2 expression and survival in primary human CD34 + hematopoietic progenitor cells .
12778345	0	Bcl-2	0,5	CD4	20,23	Bcl-2	CD4	596	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Bcl-2 expression by CD4 T lymphocytes in Vogt-Koyanagi-Harada_disease .
17090688	0	Bcl-2	14,19	CD4	102,105	Bcl-2	CD4	596	920	Gene	Gene	induction|compound|START_ENTITY critical|nsubj|induction critical|nmod|differentiation differentiation|nmod|line line|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
19385591	0	Bcl-2	71,76	CD44	0,4	Bcl-2	CD44	596	960	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|cells cells|compound|END_ENTITY	CD44 + cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast_tumours .
9359515	0	Bcl-2	37,42	CD5	59,62	Bcl-2	CD5	596	921	Gene	Gene	product|compound|START_ENTITY product|nmod|cells cells|nummod|END_ENTITY	Fludarabine ability to down-regulate Bcl-2 gene product in CD5 + leukaemic B cells : in vitro/in vivo correlations .
10754284	0	Bcl-2	38,43	CD8	71,74	Bcl-2	CD8	596	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Cutting edge : increased expression of Bcl-2 in antigen-specific memory CD8 + T cells .
11568004	0	Bcl-2	164,169	CD8	109,112	Bcl-2	CD8	596	925	Gene	Gene	induction|nmod|START_ENTITY thymocytes|nmod|induction thymocytes|dep|Interleukin-7 Interleukin-7|nmod|persistence persistence|nmod|END_ENTITY	Interleukin-7 and infection itself by human_immunodeficiency_virus_1 favor virus persistence in mature CD4 -LRB- + -RRB- CD8 -LRB- - -RRB- CD3 -LRB- + -RRB- thymocytes through sustained induction of Bcl-2 .
15034060	0	Bcl-2	61,66	CD8	13,16	Bcl-2	CD8	596	925	Gene	Gene	levels|nmod|START_ENTITY exhibit|dobj|levels +|ccomp|exhibit +|nsubj|END_ENTITY	HIV-specific CD8 + T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL .
17090688	0	Bcl-2	14,19	CD8	106,109	Bcl-2	CD8	596	925	Gene	Gene	induction|compound|START_ENTITY critical|nsubj|induction critical|nmod|differentiation differentiation|nmod|line line|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
21451108	0	Bcl-2	0,5	CD8	33,36	Bcl-2	CD8	596	925	Gene	Gene	allows|nsubj|START_ENTITY allows|dobj|cells cells|nummod|END_ENTITY	Bcl-2 allows effector and memory CD8 + T cells to tolerate higher expression of Bim .
24364474	0	Bcl-2	44,49	CD8	64,67	Bcl-2	CD8	596	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Impact of treatment with methimazole on the Bcl-2 expression in CD8 + peripheral blood lymphocytes in children with Graves ' _ disease .
7541577	0	Bcl-2	48,53	CD8	84,87	Bcl-2	CD8	596	925	Gene	Gene	expression|compound|START_ENTITY up-regulation|nmod|expression Implication|nmod|up-regulation Implication|nmod|lymphocytosis lymphocytosis|nummod|END_ENTITY	Implication of cyclosporine in up-regulation of Bcl-2 expression and maintenance of CD8 lymphocytosis in cytomegalovirus-infected allograft recipients .
8690919	0	Bcl-2	53,58	CD8	107,110	Bcl-2	CD8	596	925	Gene	Gene	down-regulation|nmod|START_ENTITY associated|nmod|down-regulation associated|nmod|T T|compound|END_ENTITY	Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8 + T lymphocytes during HIV_infection .
10766756	0	Bcl-2	19,24	CDC2	36,40	Bcl-2	CDC2	596	983	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation .
18086876	0	Bcl-2	95,100	CREB	187,191	Bcl-2	CREB	24224(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY up-regulation|nmod|expression coordinated|nsubjpass|up-regulation coordinated|dobj|protein protein|appos|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic_AMP -LRB- cAMP -RRB- response element binding protein -LRB- CREB -RRB- and cAMP-responsive CREB coactivator 2 .
18785877	0	Bcl-2	17,22	CREB	119,123	Bcl-2	CREB	24224(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY mediated|nsubjpass|expression mediated|nmod|activation activation|compound|END_ENTITY	Estrogen-induced Bcl-2 expression after spinal_cord_injury is mediated through phosphoinositide-3-kinase / Akt-dependent CREB activation .
19626458	0	Bcl-2	39,44	CREB	0,4	Bcl-2	CREB	596	1385	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	CREB , a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis .
20198332	0	Bcl-2	19,24	CREB	39,43	Bcl-2	CREB	596	1385	Gene	Gene	START_ENTITY|advcl|activating activating|dobj|END_ENTITY	PKCepsilon induces Bcl-2 by activating CREB .
24819963	0	Bcl-2	58,63	CREB	88,92	Bcl-2	CREB	24224(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
11683923	0	Bcl-2	37,42	Caspase-3	0,9	Bcl-2	Caspase-3	596	836	Gene	Gene	family|compound|START_ENTITY activity|nmod|family activity|amod|END_ENTITY	Caspase-3 activity and expression of Bcl-2 family in human neutrophils by Helicobacter_pylori water-soluble proteins .
12578676	0	Bcl-2	12,17	Caspase-3	39,48	Bcl-2	Caspase-3	596	836	Gene	Gene	Protein|compound|START_ENTITY Protein|nmod|END_ENTITY	Cleavage of Bcl-2 Protein by Activated Caspase-3 Is Associated with Inactivation of Lyn -LRB- p53/56 -RRB- Kinase Activity in Human M-07e Leukemic Cells during Apoptosis .
9818030	0	Bcl-2	64,69	Caspase-3	0,9	Bcl-2	Caspase-3	596	836	Gene	Gene	phosphorylation|compound|START_ENTITY responsible|nmod|phosphorylation responsible|nsubj|activation activation|amod|END_ENTITY	Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small_cell_lung_carcinoma Ms-1 cells .
24495616	0	Bcl-2	0,5	Caspase_3	6,15	Bcl-2	Caspase 3	403416(Tax:9615)	836	Gene	Gene	START_ENTITY|parataxis|favors favors|nsubj|imbalance imbalance|amod|END_ENTITY	Bcl-2 / Caspase_3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory_bowel_disease .
11603220	0	Bcl-2	93,98	Cellular_apoptosis_susceptibility_gene	0,38	Bcl-2	Cellular apoptosis susceptibility gene	596	1434	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|amod|END_ENTITY	Cellular_apoptosis_susceptibility_gene expression in endometrial_carcinoma : correlation with Bcl-2 , Bax , and caspase-3 expression and outcome .
9891071	0	Bcl-2	67,72	Cytochrome_c	5,17	Bcl-2	Cytochrome c	596	54205	Gene	Gene	regulated|nmod|START_ENTITY regulated|dep|factor factor|amod|END_ENTITY	Cif -LRB- Cytochrome_c efflux-inducing factor -RRB- activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid .
10684252	0	Bcl-2	22,27	Debcl	0,5	Bcl-2	Debcl	53585(Tax:7227)	53585(Tax:7227)	Gene	Gene	homologue|amod|START_ENTITY END_ENTITY|appos|homologue	Debcl , a proapoptotic Bcl-2 homologue , is a component of the Drosophila_melanogaster cell death machinery .
9829980	0	Bcl-2	8,13	Diva	0,4	Bcl-2	Diva	596	10017	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Diva , a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death .
7589255	0	Bcl-2	71,76	E1B	92,95	Bcl-2	E1B	596	6080	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Induction of p53-independent apoptosis by hygromycin_B : suppression by Bcl-2 and adenovirus E1B 19-kDa protein .
15225643	0	Bcl-2	58,63	ERK	81,84	Bcl-2	ERK	596	5594	Gene	Gene	status|nmod|START_ENTITY regulated|nsubjpass|status regulated|nmod|END_ENTITY	The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein_phosphatase_2A on the mitochondria .
16914120	0	Bcl-2	0,5	ERK	75,78	Bcl-2	ERK	24224(Tax:10116)	24338(Tax:10116)	Gene	Gene	overexpression|amod|START_ENTITY disrupts|nsubj|overexpression disrupts|nmod|activation activation|compound|END_ENTITY	Bcl-2 overexpression disrupts the morphology of PC12 cells through reduced ERK activation .
17052670	0	Bcl-2	50,55	ERK	125,128	Bcl-2	ERK	596	5594	Gene	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt .
18454859	0	Bcl-2	96,101	ERK	147,150	Bcl-2	ERK	596	5594	Gene	Gene	START_ENTITY|nmod|extracellular_signal-related_kinase extracellular_signal-related_kinase|appos|END_ENTITY	Expression of HER-2 in MCF-7 breast_cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular_signal-related_kinase -LRB- ERK -RRB- and phosphoinositide-3 kinase -LRB- PI3K -RRB- signalling pathways .
18677583	0	Bcl-2	63,68	ERK	28,31	Bcl-2	ERK	596	5594	Gene	Gene	induction|nmod|START_ENTITY Evidence|nmod|induction Evidence|nmod|END_ENTITY	Evidence for involvement of ERK , PI3K , and RSK in induction of Bcl-2 by valproate .
22504301	0	Bcl-2	43,48	ERK	114,117	Bcl-2	ERK	596	5594	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|advcl|activating activating|nmod|activation activation|nmod|END_ENTITY	Overexpression of phospholipase_D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells .
23735541	0	Bcl-2	36,41	ERK	128,131	Bcl-2	ERK	596	5594	Gene	Gene	paclitaxel|nmod|START_ENTITY activation|amod|paclitaxel induced|nmod|activation Apoptosis|acl|induced modulated|nsubjpass|Apoptosis modulated|nmod|inhibition inhibition|compound|END_ENTITY	Apoptosis induced by paclitaxel via Bcl-2 , Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition .
25996258	0	Bcl-2	16,21	ERK	39,42	Bcl-2	ERK	596	5594	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis .
19017967	0	Bcl-2	21,26	Egr2	0,4	Bcl-2	Egr2	596	1959	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	Egr2 is required for Bcl-2 induction during positive selection .
14766059	0	Bcl-2	30,35	FGFR1	23,28	Bcl-2	FGFR1	596	2260	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	-LSB- The response of bFGF , FGFR1 , Bcl-2 and caspase-3 to visible light in cultured human retinal pigment epithelium cells -RSB- .
16176796	0	Bcl-2	120,125	FK-506_binding_protein_38	30,55	Bcl-2	FK-506 binding protein 38	596	23770	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of FK-506_binding_protein_38 and its potential regulatory role on the anti-apoptotic protein Bcl-2 .
12510191	0	Bcl-2	46,51	FKBP38	31,37	Bcl-2	FKBP38	596	23770	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis .
14968553	0	Bcl-2	68,73	FKBP38	14,20	Bcl-2	FKBP38	596	23770	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	-LSB- Immunophilin FKBP38 , an inherent inhibitor of calcineurin , targets Bcl-2 to mitochondria and inhibits apoptosis -RSB- .
15733859	0	Bcl-2	21,26	FKBP38	115,121	Bcl-2	FKBP38	596	23770	Gene	Gene	loop|nmod|START_ENTITY required|nsubjpass|loop required|nmod|FK-506_binding_protein_38 FK-506_binding_protein_38|appos|END_ENTITY	The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506_binding_protein_38 -LRB- FKBP38 -RRB- .
15905180	0	Bcl-2	84,89	FKBP38	32,38	Bcl-2	FKBP38	12043(Tax:10090)	14232(Tax:10090)	Gene	Gene	reducing|dobj|START_ENTITY promotes|advcl|reducing promotes|nsubj|Interaction Interaction|nmod|presenilins presenilins|nmod|END_ENTITY	Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2 .
20048149	0	Bcl-2	72,77	FKBP38	60,66	Bcl-2	FKBP38	596	23770	Gene	Gene	regulating|nmod|START_ENTITY regulating|dobj|interaction interaction|nmod|END_ENTITY	Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL .
20139069	0	Bcl-2	16,21	FKBP38	0,6	Bcl-2	FKBP38	596	23770	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	FKBP38 protects Bcl-2 from caspase-dependent degradation .
20140889	0	Bcl-2	65,70	FKBP38	31,37	Bcl-2	FKBP38	596	23770	Gene	Gene	binding|nsubj|START_ENTITY modulates|xcomp|binding modulates|nsubj|loop loop|nmod|domain domain|compound|END_ENTITY	A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding .
22523079	0	Bcl-2	37,42	FKBP38	4,10	Bcl-2	FKBP38	596	23770	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|domain domain|compound|END_ENTITY	The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop .
24295050	0	Bcl-2	58,63	FKBP38	46,52	Bcl-2	FKBP38	596	23770	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|dobj|interaction interaction|nmod|END_ENTITY	Ca2 + / S100 proteins inhibit the interaction of FKBP38 with Bcl-2 and Hsp90 .
10920278	0	Bcl-2	0,5	Fas_ligand	36,46	Bcl-2	Fas ligand	596	356	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Bcl-2 inhibits calcineurin-mediated Fas_ligand expression in antitumor drug-treated baby hamster kidney cells .
12849704	0	Bcl-2	2,7	Fas_ligand	109,119	Bcl-2	Fas ligand	12043(Tax:10090)	14103(Tax:10090)	Gene	Gene	transgene|compound|START_ENTITY protect|nsubj|transgene protect|nmod|destruction destruction|acl|induced induced|nmod|END_ENTITY	A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas_ligand .
21485723	0	Bcl-2	28,33	Fas_ligand	65,75	Bcl-2	Fas ligand	596	356	Gene	Gene	caspase-3|compound|START_ENTITY caspase-3|acl|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
26373689	0	Bcl-2	149,154	FoxO3a	109,115	Bcl-2	FoxO3a	596	2309	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	AMP-activated protein kinase couples 3-bromopyruvate-induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins .
24240096	0	Bcl-2	15,20	GABARAP	83,90	Bcl-2	GABARAP	596	11337	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein -LRB- GABARAP -RRB- : biophysical characterization and functional implications .
18653721	0	Bcl-2	17,22	GATA-4	0,6	Bcl-2	GATA-4	596	2626	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GATA-4 regulates Bcl-2 expression in ovarian_granulosa_cell_tumors .
23469687	0	Bcl-2	68,73	Gli-1	62,67	Bcl-2	Gli-1	596	2735	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Zerumbone induces apoptosis in human renal_cell_carcinoma via Gli-1 / Bcl-2 pathway .
25281403	0	Bcl-2	35,40	Glucosylceramide_synthase	0,25	Bcl-2	Glucosylceramide synthase	596	7357	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Glucosylceramide_synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line .
25385144	0	Bcl-2	73,78	HIF-1a	58,64	Bcl-2	HIF-1a	596	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1a / miR-210 / Bcl-2 pathway in colon_cancer cells .
20668552	0	Bcl-2	0,5	HIF-1alpha	16,26	Bcl-2	HIF-1alpha	596	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stabilization stabilization|compound|END_ENTITY	Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90 .
24177192	0	Bcl-2	16,21	HoxA9	0,5	Bcl-2	HoxA9	596	3205	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia .
19671677	0	Bcl-2	14,19	HuR	34,37	Bcl-2	HuR	596	1994	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells .
15132839	0	Bcl-2	68,73	ICAD	103,107	Bcl-2	ICAD	596	1676	Gene	Gene	expression|nmod|START_ENTITY altering|dobj|expression altering|dep|END_ENTITY	Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2 / Bax and activating caspase-3 / ICAD pathway .
14636443	0	Bcl-2	15,20	IFN-gamma	82,91	Bcl-2	IFN-gamma	24224(Tax:10116)	25712(Tax:10116)	Gene	Gene	proteins|amod|START_ENTITY Expression|nmod|proteins Expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Expression of Bcl-2 and Bax proteins in rat liver fibrosis model and the role of IFN-gamma -RSB- .
18279102	0	Bcl-2	61,66	IFN-gamma	0,9	Bcl-2	IFN-gamma	596	3458	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	IFN-gamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression .
9472684	0	Bcl-2	165,170	IFN-gamma	119,128	Bcl-2	IFN-gamma	596	3458	Gene	Gene	expression|compound|START_ENTITY Apoptosis|nmod|expression Apoptosis|amod|interferon-gamma interferon-gamma|dep|END_ENTITY	Apoptosis of colorectal_adenocarcinoma -LRB- COLO 201 -RRB- by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and/or interferon-gamma -LRB- IFN-gamma -RRB- , resulting from down-modulation of Bcl-2 expression .
21117871	0	Bcl-2	98,103	IFN-y	22,27	Bcl-2	IFN-y	596	3458	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|gene gene|amod|END_ENTITY	Synergistic effect of IFN-y gene on LIGHT-induced apoptosis in HepG2 cells via down regulation of Bcl-2 .
18428028	0	Bcl-2	64,69	IGF-II	10,16	Bcl-2	IGF-II	596	3481	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Precursor IGF-II -LRB- proIGF-II -RRB- and mature IGF-II -LRB- mIGF-II -RRB- induce Bcl-2 And Bcl-X_L expression through different signaling pathways in breast_cancer cells .
11571630	0	Bcl-2	0,5	IGF-IR	39,45	Bcl-2	IGF-IR	596	3480	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Bcl-2 and M-Myc coexpression increases IGF-IR and features of malignant growth in neuroblastoma cell lines .
9252127	0	Bcl-2	58,63	IL-7	49,53	Bcl-2	IL-7	12043(Tax:10090)	16196(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression .
25744832	0	Bcl-2	81,86	IL-8	1,5	Bcl-2	IL-8	596	3576	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	-LSB- IL-8 inhibits the apoptosis of MCF-7 human breast_cancer cells by up-regulating Bcl-2 and down-regulating caspase-3 -RSB- .
26260683	0	Bcl-2	101,106	IP3_receptor	86,98	Bcl-2	IP3 receptor	596	3710	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP3_receptor / Bcl-2 complexes .
8806678	0	Bcl-2	0,5	I_kappa_B-alpha	88,103	Bcl-2	I kappa B-alpha	396282(Tax:9031)	396093(Tax:9031)	Gene	Gene	have|nsubj|START_ENTITY have|dobj|effects effects|nmod|END_ENTITY	Bcl-2 and CrmA have different effects on transformation , apoptosis and the stability of I_kappa_B-alpha in chicken spleen cells transformed by temperature-sensitive v-Rel oncoproteins .
18158619	0	Bcl-2	15,20	Id-1	0,4	Bcl-2	Id-1	596	3397	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast_cancer cells .
11208834	0	Bcl-2	17,22	IgH	23,26	Bcl-2	IgH	596	3492	Gene	Gene	rearrangement|nmod|START_ENTITY rearrangement|compound|END_ENTITY	Frequency of the Bcl-2 / IgH rearrangement in normal individuals : implications for the monitoring of disease in patients with follicular_lymphoma .
12139744	0	Bcl-2	68,73	IgH	74,77	Bcl-2	IgH	596	3492	Gene	Gene	assay|nmod|START_ENTITY assay|parataxis|rearrangements rearrangements|nsubj|END_ENTITY	JH probe real-time quantitative polymerase chain reaction assay for Bcl-2 / IgH rearrangements .
12663733	0	Bcl-2	29,34	IgH	35,38	Bcl-2	IgH	596	3492	Gene	Gene	START_ENTITY|parataxis|common common|nsubj|rearrangements rearrangements|compound|END_ENTITY	PCR-detectable nonneoplastic Bcl-2 / IgH rearrangements are common in normal subjects and cancer patients at diagnosis but rare in subjects treated with chemotherapy .
12962724	0	Bcl-2	14,19	IgH	20,23	Bcl-2	IgH	596	3492	Gene	Gene	reaction|compound|START_ENTITY reaction|compound|END_ENTITY	Recurrence of Bcl-2 / IgH polymerase chain reaction positivity following a prolonged molecular remission can be unrelated to the original follicular_lymphoma clone .
18072430	0	Bcl-2	11,16	IgH	17,20	Bcl-2	IgH	596	3492	Gene	Gene	START_ENTITY|parataxis|implies implies|nsubj|negativity negativity|compound|END_ENTITY	-LSB- Achieving Bcl-2 / IgH negativity in peripheral blood/bone marrow after therapy implies better prognosis for patients with follicular_lymphoma -RSB- .
18636259	0	Bcl-2	97,102	IgH	103,106	Bcl-2	IgH	596	3492	Gene	Gene	monitoring|nmod|START_ENTITY PCR|nmod|monitoring PCR|acl|PCR PCR|parataxis|rearrangement rearrangement|nsubj|END_ENTITY	Commercial LightCycler-based quantitative real-time PCR compared to nested PCR for monitoring of Bcl-2 / IgH rearrangement in patients with follicular_lymphoma .
18665753	0	Bcl-2	57,62	IgH	63,66	Bcl-2	IgH	596	3492	Gene	Gene	characteristics|nmod|START_ENTITY characteristics|dep|rearrangement rearrangement|compound|END_ENTITY	Molecular characteristics and prognostic significance of Bcl-2 / IgH gene rearrangement in Serbian follicular_lymphoma patients .
1902122	0	Bcl-2	65,70	IgH	24,27	Bcl-2	IgH	596	3492	Gene	Gene	gene|compound|START_ENTITY organization|nmod|gene organization|nmod|gene gene|compound|END_ENTITY	Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t -LRB- 14 ; 18 -RRB- - positive lymphoma .
19858392	0	Bcl-2	30,35	IgH	36,39	Bcl-2	IgH	596	3492	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Quantitative PCR analysis for Bcl-2 / IgH in a phase III study of Yttrium-90 Ibritumomab Tiuxetan as consolidation of first remission in patients with follicular_lymphoma .
21309729	0	Bcl-2	18,23	IgH	24,27	Bcl-2	IgH	596	3492	Gene	Gene	Identification|nmod|START_ENTITY Identification|parataxis|using using|nsubj|sequences sequences|compound|END_ENTITY	Identification of Bcl-2 / IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis .
22052344	0	Bcl-2	0,5	IgH	6,9	Bcl-2	IgH	596	3492	Gene	Gene	START_ENTITY|parataxis|infiltration infiltration|nsubj|expression expression|compound|END_ENTITY	Bcl-2 / IgH expression in minimal bone marrow infiltration by follicular_lymphoma cells .
26239087	0	Bcl-2	32,37	IgH	38,41	Bcl-2	IgH	596	3492	Gene	Gene	circulating|dobj|START_ENTITY value|acl|circulating Prognostic|dobj|value levels|dep|Prognostic levels|compound|END_ENTITY	Prognostic value of circulating Bcl-2 / IgH levels in patients with follicular_lymphoma receiving first-line immunochemotherapy .
17565996	0	Bcl-2	72,77	IkappaBalpha	111,123	Bcl-2	IkappaBalpha	596	4792	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha .
8839847	0	Bcl-2	25,30	Interleukin-10	0,14	Bcl-2	Interleukin-10	596	3586	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-10 increases Bcl-2 expression and survival in primary human CD34 + hematopoietic progenitor cells .
9370916	0	Bcl-2	94,99	Interleukin-10	0,14	Bcl-2	Interleukin-10	596	3586	Gene	Gene	upregulation|nmod|START_ENTITY association|nmod|upregulation rescues|parataxis|association rescues|nsubj|END_ENTITY	Interleukin-10 rescues T cells from apoptotic cell death : association with an upregulation of Bcl-2 .
15467450	0	Bcl-2	23,28	JNK	0,3	Bcl-2	JNK	596	5599	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	JNK is associated with Bcl-2 and PP1 in mitochondria : paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2 .
22822094	0	Bcl-2	64,69	JNK	16,19	Bcl-2	JNK	596	5599	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl_tetrasulfide-induced mitotic_arrest to apoptosis .
26795455	0	Bcl-2	98,103	Jmjd3	20,25	Bcl-2	Jmjd3	596	23135	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim .
15654978	0	Bcl-2	0,5	KIT	70,73	Bcl-2	KIT	12043(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Bcl-2 reduced and fas activated by the inhibition of stem_cell_factor / KIT signaling in murine melanocyte precursors .
23850692	0	Bcl-2	130,135	LRIG1	0,5	Bcl-2	LRIG1	596	26018	Gene	Gene	down-regulation|nmod|START_ENTITY cells|nmod|down-regulation dictates|nmod|cells dictates|nsubj|END_ENTITY	LRIG1 dictates the chemo-sensitivity of temozolomide -LRB- TMZ -RRB- in U251 glioblastoma cells via down-regulation of EGFR/topoisomerase -2 / Bcl-2 .
23889688	0	Bcl-2	103,108	MMP-2	79,84	Bcl-2	MMP-2	24224(Tax:10116)	81686(Tax:10116)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-a activation in rat hearts subjected to global ischaemia-reperfusion .
19088028	0	Bcl-2	98,103	Mcl-1	70,75	Bcl-2	Mcl-1	596	4170	Gene	Gene	expressing|nmod|START_ENTITY expressing|xcomp|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
9002967	0	Bcl-2	9,14	Mcl-1	0,5	Bcl-2	Mcl-1	12043(Tax:10090)	17210(Tax:10090)	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Mcl-1 , a Bcl-2 family member , delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions .
21455217	0	Bcl-2	41,46	MiR-148a	0,8	Bcl-2	MiR-148a	596	406940	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal_cancer .
22623155	0	Bcl-2	89,94	MiR-34a	0,7	Bcl-2	MiR-34a	596	407040	Gene	Gene	down-regulation|nmod|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	MiR-34a inhibits proliferation and migration_of_breast_cancer through down-regulation of Bcl-2 and SIRT1 .
25910896	0	Bcl-2	84,89	MiR-34a	0,7	Bcl-2	MiR-34a	596	407040	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2 .
23999873	0	Bcl-2	77,82	MiR-429	0,7	Bcl-2	MiR-429	596	554210	Gene	Gene	targeting|dobj|START_ENTITY induces|advcl|targeting induces|nsubj|up-regulation up-regulation|amod|END_ENTITY	MiR-429 up-regulation induces apoptosis and suppresses invasion by targeting Bcl-2 and SP-1 in esophageal_carcinoma .
26511969	0	Bcl-2	55,60	MiR-429	0,7	Bcl-2	MiR-429	596	554210	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	MiR-429 induces apoptosis of glioblastoma cell through Bcl-2 .
26513239	0	Bcl-2	57,62	MiR-429	0,7	Bcl-2	MiR-429	596	554210	Gene	Gene	Apoptosis|dep|START_ENTITY Apoptosis|compound|END_ENTITY	MiR-429 Induces Gastric_Carcinoma Cell Apoptosis Through Bcl-2 .
19506341	0	Bcl-2	58,63	MicroRNA-1	0,10	Bcl-2	MicroRNA-1	24224(Tax:10116)	100314077(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2 .
25898913	0	Bcl-2	22,27	MicroRNA-181c	0,13	Bcl-2	MicroRNA-181c	596	406957	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells .
9535847	0	Bcl-2	13,18	Mtd	0,3	Bcl-2	Mtd	596	4493	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	Mtd , a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL .
9535847	0	Bcl-2	95,100	Mtd	0,3	Bcl-2	Mtd	596	4493	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Mtd , a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL .
10504052	0	Bcl-2	26,31	N-ras	8,13	Bcl-2	N-ras	596	4893	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice .
17418785	0	Bcl-2	0,5	NALP1	83,88	Bcl-2	NALP1	596	22861	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1 .
10021463	0	Bcl-2	0,5	NF-kappaB	96,105	Bcl-2	NF-kappaB	596	4790	Gene	Gene	serve|nsubj|START_ENTITY serve|nmod|inhibition inhibition|nmod|END_ENTITY	Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB .
10049353	0	Bcl-2	16,21	NF-kappaB	77,86	Bcl-2	NF-kappaB	596	4790	Gene	Gene	Bfl-1|amod|START_ENTITY Bfl-1|parataxis|target target|nmod|END_ENTITY	The prosurvival Bcl-2 homolog Bfl-1 / A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis .
10454539	0	Bcl-2	36,41	NF-kappaB	0,9	Bcl-2	NF-kappaB	596	4790	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl -1 to preferentially suppress chemotherapy-induced apoptosis .
10727020	0	Bcl-2	175,180	NF-kappaB	112,121	Bcl-2	NF-kappaB	12043(Tax:10090)	18033(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
10727020	0	Bcl-2	175,180	NF-kappaB	36,45	Bcl-2	NF-kappaB	12043(Tax:10090)	18033(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY NF-kappaB|nmod|function END_ENTITY|parataxis|NF-kappaB	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
10727020	0	Bcl-2	58,63	NF-kappaB	112,121	Bcl-2	NF-kappaB	12043(Tax:10090)	18033(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY NF-kappaB|nmod|protein NF-kappaB|parataxis|END_ENTITY	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
10727020	0	Bcl-2	58,63	NF-kappaB	36,45	Bcl-2	NF-kappaB	12043(Tax:10090)	18033(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
12032828	0	Bcl-2	20,25	NF-kappaB	0,9	Bcl-2	NF-kappaB	596	4790	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	NF-kappaB activates Bcl-2 expression in t -LRB- 14 ; 18 -RRB- lymphoma cells .
15325238	0	Bcl-2	33,38	NF-kappaB	59,68	Bcl-2	NF-kappaB	596	4790	Gene	Gene	mechanisms|nmod|START_ENTITY retrospective|nmod|mechanisms retrospective|nmod|signaling signaling|compound|END_ENTITY	On the antioxidant mechanisms of Bcl-2 : a retrospective of NF-kappaB signaling and oxidative stress .
8698809	0	Bcl-2	0,5	NF-kappaB	58,67	Bcl-2	NF-kappaB	596	4790	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|activity activity|nmod|END_ENTITY	Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis .
24819963	0	Bcl-2	58,63	NFk-B	75,80	Bcl-2	NFk-B	24224(Tax:10116)	81736(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
10085086	0	Bcl-2	30,35	NFkappaB	65,73	Bcl-2	NFkappaB	596	4790	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|compound|END_ENTITY	Tumor_necrosis_factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons .
11055326	0	Bcl-2	0,5	NFkappaB	21,29	Bcl-2	NFkappaB	596	4790	Gene	Gene	intersects|nsubj|START_ENTITY intersects|dep|signalling signalling|nsubj|END_ENTITY	Bcl-2 intersects the NFkappaB signalling pathway and suppresses apoptosis in ventricular myocytes .
9727009	0	Bcl-2	0,5	NFkappaB	41,49	Bcl-2	NFkappaB	596	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha .
15140194	0	Bcl-2	62,67	Neurotrophin-3	0,14	Bcl-2	Neurotrophin-3	596	4908	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Neurotrophin-3 and a CREB-mediated signaling pathway regulate Bcl-2 expression in oligodendrocyte progenitor cells .
10807576	0	Bcl-2	31,36	Noxa	0,4	Bcl-2	Noxa	12043(Tax:10090)	58801(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Noxa , a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis .
23429261	0	Bcl-2	94,99	Noxa	50,54	Bcl-2	Noxa	596	5366	Gene	Gene	effects|nmod|START_ENTITY effects|dep|induction induction|nmod|END_ENTITY	pRb/E2F -1 - mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2 / Bcl-xL inhibitor ABT-737 .
21586279	0	Bcl-2	81,86	P27	76,79	Bcl-2	P27	24224(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Ligustrazine inhibits lipopolysaccharide-induced proliferation by affecting P27 , Bcl-2 expression in rat mesangial cells .
18652568	0	Bcl-2	76,81	P53	71,74	Bcl-2	P53	12043(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY -LSB-|nsubj|activation -LSB-|ccomp|induces induces|nmod|modulation modulation|nmod|END_ENTITY	Inositol_hexaphosphate induces apoptosis by coordinative modulation of P53 , Bcl-2 and sequential activation of caspases in 7,12 dimethylbenz -LSB- a -RSB- anthracene exposed mouse epidermis .
21544463	0	Bcl-2	5,10	P53	0,3	Bcl-2	P53	596	7157	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	P53 , Bcl-2 expression and cell proliferation in benign breast lesions .
18604733	0	Bcl-2	47,52	PCNA	64,68	Bcl-2	PCNA	596	5111	Gene	Gene	p53|compound|START_ENTITY p53|dep|END_ENTITY	Apoptosis and proliferation related molecules -LRB- Bcl-2 , Bax , p53 , PCNA -RRB- in papillary_microcarcinoma versus papillary_carcinoma of the thyroid .
20198332	0	Bcl-2	19,24	PKCepsilon	0,10	Bcl-2	PKCepsilon	596	5581	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	PKCepsilon induces Bcl-2 by activating CREB .
15259021	0	Bcl-2	20,25	PLCgamma2	0,9	Bcl-2	PLCgamma2	12043(Tax:10090)	234779(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	PLCgamma2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells .
16085054	0	Bcl-2	14,19	PXR	85,88	Bcl-2	PXR	596	8856	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes .
12644474	0	Bcl-2	34,39	Par-4	0,5	Bcl-2	Par-4	596	5074	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter .
9989812	0	Bcl-2	42,47	Par-4	127,132	Bcl-2	Par-4	596	347745	Gene	Gene	patterns|nmod|START_ENTITY patterns|amod|consistent consistent|nmod|down-regulation down-regulation|nmod|Bcl-2 Bcl-2|nmod|END_ENTITY	Mutually exclusive expression patterns of Bcl-2 and Par-4 in human prostate tumors consistent with down-regulation of Bcl-2 by Par-4 .
17785366	0	Bcl-2	32,37	Progesterone_receptor	0,21	Bcl-2	Progesterone receptor	596	5241	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Progesterone_receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine_leiomyoma cells .
23150431	0	Bcl-2	14,19	RCAN1	46,51	Bcl-2	RCAN1	596	1827	Gene	Gene	expression|compound|START_ENTITY contributes|nsubj|expression contributes|xcomp|END_ENTITY	CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen_peroxide-induced neuronal_death .
23719266	0	Bcl-2	15,20	RRM2	0,4	Bcl-2	RRM2	596	6241	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RRM2 regulates Bcl-2 in head_and_neck_and_lung_cancers : a potential target for cancer therapy .
10400418	0	Bcl-2	98,103	Raf-1	92,97	Bcl-2	Raf-1	596	5894	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|dep|phosphorylation	Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1 / Bcl-2 phosphorylation and apoptosis in leukemia cells .
12488548	0	Bcl-2	72,77	Raf-1	120,125	Bcl-2	Raf-1	596	5894	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver_cancer cell lines .
8929532	0	Bcl-2	0,5	Raf-1	33,38	Bcl-2	Raf-1	596	5894	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Bcl-2 targets the protein kinase Raf-1 to mitochondria .
21158042	0	Bcl-2	45,50	Rb1	12,15	Bcl-2	Rb1	596	5925	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of Rb1 and Rg1 on the expression of Bcl-2 , Bax in apoptosis of HK-2 cells induced by the serum of kidney_ischemia / reperfusion -RSB- .
24606742	0	Bcl-2	90,95	SHH	100,103	Bcl-2	SHH	596	6469	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Acyldepsipeptide 1 induces apoptosis in renal_cancer cells by down-regulation of Gli and Bcl-2 via SHH pathway -RSB- .
10970187	0	Bcl-2	59,64	SMN	40,43	Bcl-2	SMN	596	6606	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Does the survival_motor_neuron_protein -LRB- SMN -RRB- interact with Bcl-2 ?
15057274	0	Bcl-2	14,19	SRF	0,3	Bcl-2	SRF	12043(Tax:10090)	20807(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development .
23684705	0	Bcl-2	21,26	Syk	14,17	Bcl-2	Syk	596	6850	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation by Syk of Bcl-2 , calcium and the calpain-calpastatin proteolytic system in human breast_cancer cells .
25867342	0	Bcl-2	47,52	TIEG1	10,15	Bcl-2	TIEG1	596	7071	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of TIEG1 on apoptosis and expression of Bcl-2 / Bax and Pten in leukemic cell lines .
26366732	0	Bcl-2	76,81	TIMP-1	0,6	Bcl-2	TIMP-1	596	7076	Gene	Gene	Apoptosis|nmod|START_ENTITY Apoptosis|compound|END_ENTITY	TIMP-1 Inhibits Apoptosis in Lung_Adenocarcinoma Cells via Interaction with Bcl-2 .
11519857	0	Bcl-2	70,75	TP53	0,4	Bcl-2	TP53	596	7157	Gene	Gene	mutations|appos|START_ENTITY mutations|nummod|END_ENTITY	TP53 gene mutations , nuclear p53 accumulation , expression of Waf/p21 , Bcl-2 , and CD95 -LRB- APO-1 / Fas -RRB- proteins are not prognostic factors in de novo glioblastoma multiforme .
16356391	0	Bcl-2	6,11	TP53	0,4	Bcl-2	TP53	596	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	TP53 , Bcl-2 and growth_hormone receptor expression in cutaneous_squamous_cell_carcinoma .
22077405	0	Bcl-2	68,73	TP53	40,44	Bcl-2	TP53	403416(Tax:9615)	403869(Tax:9615)	Gene	Gene	proteins|compound|START_ENTITY Detection|nmod|proteins Detection|nmod|END_ENTITY	Detection of the tumour suppressor gene TP53 and expression of p53 , Bcl-2 and p63 proteins in canine transmissible venereal_tumour .
10085086	0	Bcl-2	30,35	Tumor_necrosis_factor	0,21	Bcl-2	Tumor necrosis factor	596	7124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons .
11877669	0	Bcl-2	17,22	VEGF	0,4	Bcl-2	VEGF	596	7422	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells .
11895790	0	Bcl-2	77,82	VEGF	0,4	Bcl-2	VEGF	596	7422	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression promotes|nmod|induction promotes|nsubj|END_ENTITY	VEGF -LRB- 165 -RRB- promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition .
12205045	0	Bcl-2	0,5	VEGF	76,80	Bcl-2	VEGF	596	7422	Gene	Gene	overexpression|amod|START_ENTITY increases|nsubj|overexpression increases|nmod|stabilization stabilization|amod|END_ENTITY	Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity .
19495772	0	Bcl-2	27,32	VEGF	0,4	Bcl-2	VEGF	596	7422	Gene	Gene	signaling|xcomp|START_ENTITY expression|acl|signaling induces|dobj|expression induces|nsubj|END_ENTITY	VEGF induces expression of Bcl-2 and multiple signaling factors in microvascular endothelial cells in a prostate_cancer model .
25565814	0	Bcl-2	109,114	VPS34	115,120	Bcl-2	VPS34	596	5289	Gene	Gene	complex|dep|START_ENTITY complex|compound|END_ENTITY	Ferroferric_oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin_1 / Bcl-2 / VPS34 complex .
9582377	0	Bcl-2	84,89	Vascular_endothelial_growth_factor	0,34	Bcl-2	Vascular endothelial growth factor	596	7422	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells .
16474842	0	Bcl-2	65,70	Vav1	10,14	Bcl-2	Vav1	596	7409	Gene	Gene	proteins|compound|START_ENTITY inhibition|nmod|proteins apoptosis|nmod|inhibition induces|dobj|apoptosis induces|nsubj|END_ENTITY	Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation .
21151158	0	Bcl-2	64,69	Vav1	56,60	Bcl-2	Vav1	596	7409	Gene	Gene	transcription|compound|START_ENTITY END_ENTITY|nmod|transcription	The distinct role of guanine_nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells .
24880064	0	Bcl-2	15,20	Vav1	0,4	Bcl-2	Vav1	596	7409	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells .
26035796	0	Bcl-2	75,80	adrenomedullin	40,54	Bcl-2	adrenomedullin	596	133	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Hypoxia-induced apoptosis is blocked by adrenomedullin via upregulation of Bcl-2 in human osteosarcoma cells .
21393385	0	Bcl-2	119,124	bad	84,87	Bcl-2	bad	596	572	Gene	Gene	family|compound|START_ENTITY protein|nmod|family END_ENTITY|appos|protein	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21393385	0	Bcl-2	4,9	bad	84,87	Bcl-2	bad	596	572	Gene	Gene	domain|compound|START_ENTITY reveals|nsubj|domain reveals|dobj|regulation regulation|nmod|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
11380405	0	Bcl-2	0,5	basic_fibroblast_growth_factor	50,80	Bcl-2	basic fibroblast growth factor	596	2247	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Bcl-2 expression correlates positively with serum basic_fibroblast_growth_factor -LRB- bFGF -RRB- and negatively with cellular vascular_endothelial_growth_factor -LRB- VEGF -RRB- in patients with chronic_lymphocytic_leukaemia .
10363969	0	Bcl-2	8,13	bax	34,37	Bcl-2	bax	596	581	Gene	Gene	Gain|nmod|START_ENTITY potent|nsubj|Gain potent|nmod|loss loss|compound|END_ENTITY	Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo .
17326408	0	Bcl-2	51,56	bax	58,61	Bcl-2	bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	-LSB- Effect of weiganli on apoptosis and expression of Bcl-2 , bax protein in bone marrow nucleated cells of anemic mice -RSB- .
8608975	0	Bcl-2	0,5	bax	6,9	Bcl-2	bax	596	581	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Bcl-2 / bax mRNA expression ratio as prognostic factor in low-grade urinary_bladder_cancer .
8922409	0	Bcl-2	58,63	bax	80,83	Bcl-2	bax	596	581	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Amyloid beta peptide of Alzheimer 's _ disease downregulates Bcl-2 and upregulates bax expression in human neurons .
12452453	0	Bcl-2	0,5	bcl-xL	6,12	Bcl-2	bcl-xL	596	598	Gene	Gene	START_ENTITY|parataxis|sensitizes sensitizes|nsubj|treatment treatment|amod|END_ENTITY	Bcl-2 / bcl-xL bispecific antisense treatment sensitizes breast_carcinoma cells to doxorubicin , paclitaxel and cyclophosphamide .
12904174	0	Bcl-2	24,29	bcl-xL	70,76	Bcl-2	bcl-xL	596	598	Gene	Gene	members|compound|START_ENTITY regulation|nmod|members regulation|dep|expression expression|nmod|cells cells|amod|END_ENTITY	Prolactin regulation of Bcl-2 family members : increased expression of bcl-xL but not mcl-1 or bad in Nb2-T cells .
24554038	0	Bcl-2	88,93	beclin_1	14,22	Bcl-2	beclin 1	596	8678	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of beclin_1 in primary salivary adenoid_cystic_carcinoma and its relation to Bcl-2 and p53 and prognosis .
26683082	0	Bcl-2	113,118	beclin_1	119,127	Bcl-2	beclin 1	596	8678	Gene	Gene	JNK_1|dep|START_ENTITY activating|dobj|JNK_1 a-synuclein|advcl|activating pathway|amod|a-synuclein pathway|amod|END_ENTITY	Fasudil , a Rho kinase inhibitor , promotes the autophagic degradation of A53T a-synuclein by activating the JNK_1 / Bcl-2 / beclin_1 pathway .
17121585	0	Bcl-2	21,26	bfl-1	41,46	Bcl-2	bfl-1	596	597	Gene	Gene	member|compound|START_ENTITY Polymorphisms|nmod|member Polymorphisms|amod|END_ENTITY	Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic_dermatitis .
11193044	0	Bcl-2	30,35	bim	50,53	Bcl-2	bim	12043(Tax:10090)	12125(Tax:10090)	Gene	Gene	member|compound|START_ENTITY role|nmod|member END_ENTITY|nsubj|role	The role of the pro-apoptotic Bcl-2 family member bim in physiological cell death .
17026529	0	Bcl-2	134,139	c-Fos	111,116	Bcl-2	c-Fos	24224(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway : involvement of c-Fos in PACAP-induced Bcl-2 expression .
19079363	0	Bcl-2	84,89	c-Fos	0,5	Bcl-2	c-Fos	12043(Tax:10090)	14281(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2 .
14733915	0	Bcl-2	0,5	c-Jun_N-terminal_kinase	51,74	Bcl-2	c-Jun N-terminal kinase	596	5599	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|extension extension|nmod|activation activation|nmod|END_ENTITY	Bcl-2 enhances neurite extension via activation of c-Jun_N-terminal_kinase .
16243436	0	Bcl-2	107,112	c-Jun_N-terminal_kinase	141,164	Bcl-2	c-Jun N-terminal kinase	24224(Tax:10116)	116554(Tax:10116)	Gene	Gene	Bax|nmod|START_ENTITY expression|appos|Bax dimmers|dep|expression mediated|nsubjpass|dimmers mediated|nmod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
17262823	0	Bcl-2	166,171	c-Jun_N-terminal_kinase	127,150	Bcl-2	c-Jun N-terminal kinase	596	5599	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Pretreatment with low nitric_oxide protects osteoblasts from high nitric_oxide-induced apoptotic insults through regulation of c-Jun_N-terminal_kinase / c-Jun-mediated Bcl-2 gene expression and protein translocation .
19545597	0	Bcl-2	19,24	c-Jun_N-terminal_kinase	61,84	Bcl-2	c-Jun N-terminal kinase	596	5599	Gene	Gene	START_ENTITY|nmod|caspase-3 caspase-3|nmod|pathway pathway|amod|END_ENTITY	Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun_N-terminal_kinase pathway in ursolic_acid-induced DU145 cells apoptosis .
11337016	0	Bcl-2	82,87	c-Myc	56,61	Bcl-2	c-Myc	596	4609	Gene	Gene	down-regulate|nmod|START_ENTITY down-regulate|dobj|expression expression|nmod|protein protein|amod|END_ENTITY	Labdane type diterpenes down-regulate the expression of c-Myc protein , but not of Bcl-2 , in human leukemia T-cells undergoing apoptosis .
11704823	0	Bcl-2	0,5	c-Myc	48,53	Bcl-2	c-Myc	596	4609	Gene	Gene	target|nsubj|START_ENTITY target|acl|suppressed suppressed|nmod|END_ENTITY	Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1 .
17331788	0	Bcl-2	173,178	c-Myc	0,5	Bcl-2	c-Myc	24224(Tax:10116)	24577(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY suberoylanilide_hydroxamic_acid|nmod|expression induced|nmod|suberoylanilide_hydroxamic_acid apoptosis|acl|induced activation|nmod|apoptosis sensitizes|dobj|activation sensitizes|nsubj|overexpression overexpression|amod|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
21640157	0	Bcl-2	0,5	c-Myc	42,47	Bcl-2	c-Myc	596	4609	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Bcl-2 is a better therapeutic target than c-Myc , but attacking both could be a more effective treatment strategy for B-cell_lymphoma with concurrent Bcl-2 and c-Myc overexpression .
7987827	0	Bcl-2	23,28	c-Myc	65,70	Bcl-2	c-Myc	100774873	4609	Gene	Gene	family|compound|START_ENTITY member|nmod|family induced|nsubj|member induced|nmod|overexpression overexpression|amod|END_ENTITY	Mcl-1 , a member of the Bcl-2 family , delays apoptosis induced by c-Myc overexpression in Chinese_hamster ovary cells .
9419976	0	Bcl-2	0,5	c-fos	15,20	Bcl-2	c-fos	12043(Tax:10090)	14281(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Bcl-2 inhibits c-fos induction by calcium .
16683403	0	Bcl-2	15,20	c-myc	54,59	Bcl-2	c-myc	596	4609	Gene	Gene	protein|compound|START_ENTITY Expression|nmod|protein Expression|nmod|gene gene|amod|END_ENTITY	-LSB- Expression of Bcl-2 protein and the amplification of c-myc gene in patients with chronic_myeloid_leukemia -RSB- .
17487378	0	Bcl-2	65,70	c-myc	44,49	Bcl-2	c-myc	596	4609	Gene	Gene	correlates|compound|START_ENTITY -RSB-|parataxis|correlates abundance|dep|-RSB- abundance|dobj|index index|amod|END_ENTITY	The interactive transcript abundance index -LSB- c-myc * p73alpha -RSB- / -LSB- p21 * Bcl-2 -RSB- correlates with baseline level of apoptosis and response to CPT-11 in human bronchogenic_carcinoma cell lines .
10086332	0	Bcl-2	0,5	caspase-2	28,37	Bcl-2	caspase-2	596	835	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|cascade cascade|amod|END_ENTITY	Bcl-2 regulates a caspase-3 / caspase-2 apoptotic cascade in cytosolic extracts .
10086332	0	Bcl-2	0,5	caspase-3	18,27	Bcl-2	caspase-3	596	836	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|cascade cascade|amod|END_ENTITY	Bcl-2 regulates a caspase-3 / caspase-2 apoptotic cascade in cytosolic extracts .
11328751	0	Bcl-2	95,100	caspase-3	67,76	Bcl-2	caspase-3	596	836	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Blue light-induced apoptosis of A2E-containing RPE : involvement of caspase-3 and protection by Bcl-2 .
11393587	0	Bcl-2	103,108	caspase-3	73,82	Bcl-2	caspase-3	596	836	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Butein , a plant polyphenol , induces apoptosis concomitant with increased caspase-3 activity , decreased Bcl-2 expression and increased Bax expression in HL-60 cells .
11568056	0	Bcl-2	16,21	caspase-3	30,39	Bcl-2	caspase-3	24224(Tax:10116)	25402(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts .
11577002	0	Bcl-2	0,5	caspase-3	93,102	Bcl-2	caspase-3	596	836	Gene	Gene	overexpression|amod|START_ENTITY attenuates|nsubj|overexpression attenuates|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity .
11992642	0	Bcl-2	51,56	caspase-3	29,38	Bcl-2	caspase-3	596	836	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|amod|END_ENTITY	Variation in the kinetics of caspase-3 activation , Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian_cancer cell lines as a response to docetaxel .
12148891	0	Bcl-2	120,125	caspase-3	92,101	Bcl-2	caspase-3	596	836	Gene	Gene	bax/ratio|compound|START_ENTITY activation|nmod|bax/ratio activation|nmod|END_ENTITY	Hydroxychloroquine-induced apoptosis of chronic_lymphocytic_leukemia involves activation of caspase-3 and modulation of Bcl-2 / bax/ratio .
12150944	0	Bcl-2	128,133	caspase-3	94,103	Bcl-2	caspase-3	596	836	Gene	Gene	regulated|nmod|START_ENTITY activation|acl|regulated activation|amod|END_ENTITY	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL .
16002698	0	Bcl-2	11,16	caspase-3	49,58	Bcl-2	caspase-3	596	836	Gene	Gene	levels|compound|START_ENTITY levels|nmod|activation activation|amod|END_ENTITY	Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation : molecular genetic tests of computational model predictions .
16213739	0	Bcl-2	0,5	caspase-3	49,58	Bcl-2	caspase-3	596	836	Gene	Gene	phosphorylation|amod|START_ENTITY precedes|nsubj|phosphorylation precedes|dobj|activation activation|amod|END_ENTITY	Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic-ischemic_injury .
17096883	0	Bcl-2	101,106	caspase-3	73,82	Bcl-2	caspase-3	596	836	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Ouabain-induced apoptosis of Jurkat cells correlates with activation of caspase-3 and regulation of Bcl-2 gene family -RSB- .
17494993	0	Bcl-2	0,5	caspase-3	28,37	Bcl-2	caspase-3	12043(Tax:10090)	12367(Tax:10090)	Gene	Gene	delays|amod|START_ENTITY END_ENTITY|nsubj|delays	Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar_degeneration in prion-deficient mice that overexpress amino-terminally truncated prion .
19408126	0	Bcl-2	73,78	caspase-3	88,97	Bcl-2	caspase-3	12043(Tax:10090)	12367(Tax:10090)	Gene	Gene	apoptosis|nmod|START_ENTITY mediated|nsubj|apoptosis mediated|dobj|activation activation|amod|END_ENTITY	Glycogen_synthase_kinase-3beta regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells .
22467255	0	Bcl-2	90,95	caspase-3	62,71	Bcl-2	caspase-3	596	836	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	A pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary_carcinoma cells .
24496691	0	Bcl-2	116,121	caspase-3	88,97	Bcl-2	caspase-3	596	836	Gene	Gene	family|compound|START_ENTITY apoptosis|nmod|family apoptosis|nmod|activation activation|nmod|END_ENTITY	Dioscin-induced apoptosis of human LNCaP_prostate_carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family .
27064014	0	Bcl-2	201,206	caspase-3	169,178	Bcl-2	caspase-3	596	836	Gene	Gene	levels|compound|START_ENTITY decreased|nsubj|levels decreased|ccomp|cytotoxic cytotoxic|xcomp|induce induce|nmod|activation activation|amod|END_ENTITY	Isololiolide , a carotenoid metabolite isolated from the brown_alga_Cystoseira_tamariscifolia , is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation , decreased Bcl-2 levels , increased p53 expression and PARP cleavage .
9200447	0	Bcl-2	0,5	caspase-3	67,76	Bcl-2	caspase-3	596	836	Gene	Gene	expression|amod|START_ENTITY leads|nsubj|expression leads|xcomp|functional functional|dobj|inhibition inhibition|nmod|family family|amod|END_ENTITY	Bcl-2 expression in target cells leads to functional inhibition of caspase-3 protease family in human NK and lymphokine-activated killer cell granule-mediated apoptosis .
10203579	0	Bcl-2	0,5	caspase_3	47,56	Bcl-2	caspase 3	596	836	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|activation activation|amod|END_ENTITY	Bcl-2 protects against beta-lapachone-mediated caspase_3 activation and apoptosis in human myeloid_leukemia -LRB- HL-60 -RRB- cells .
16111802	0	Bcl-2	119,124	caspase_3	141,150	Bcl-2	caspase 3	596	836	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase_3 activity .
20132233	0	Bcl-2	79,84	caspase_3	118,127	Bcl-2	caspase 3	596	836	Gene	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Erythropoietin inhibits gamma-irradiation-induced apoptosis by upregulation of Bcl-2 and decreasing the activation of caspase_3 in human UT-7 / erythropoietin cell line .
21910070	0	Bcl-2	104,109	caspase_3	135,144	Bcl-2	caspase 3	596	836	Gene	Gene	family|compound|START_ENTITY family|nmod|END_ENTITY	Pien Tze Huang induced apoptosis in human colon_cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase_3 .
23013026	0	Bcl-2	9,14	creb	36,40	Bcl-2	creb	24224(Tax:10116)	81646(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	-LSB- Role of Bcl-2 in the regulation of creb activity and vasopressin expression in the hypothalamic neurons of rats -RSB- .
14739607	0	Bcl-2	57,62	cytochrome_C	73,85	Bcl-2	cytochrome C	596	54205	Gene	Gene	START_ENTITY|dep|roles roles|nmod|release release|amod|END_ENTITY	Apoptosis modulatory activities of transiently expressed Bcl-2 : roles in cytochrome_C release and Bax regulation .
14966123	0	Bcl-2	69,74	cytochrome_C	29,41	Bcl-2	cytochrome C	596	54205	Gene	Gene	inhibitor|compound|START_ENTITY induced|nmod|inhibitor induced|nsubj|signals signals|nmod|release release|amod|END_ENTITY	Critical upstream signals of cytochrome_C release induced by a novel Bcl-2 inhibitor .
10021389	0	Bcl-2	0,5	cytochrome_c	55,67	Bcl-2	cytochrome c	596	54205	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Bcl-2 regulates amplification of caspase activation by cytochrome_c .
10409669	0	Bcl-2	32,37	cytochrome_c	58,70	Bcl-2	cytochrome c	596	54205	Gene	Gene	cleavage|nmod|START_ENTITY promotes|nsubj|cleavage promotes|dobj|release release|nmod|END_ENTITY	Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome_c .
10462033	0	Bcl-2	130,135	cytochrome_c	31,43	Bcl-2	cytochrome c	596	54205	Gene	Gene	prevent|nsubj|START_ENTITY epitope|parataxis|prevent epitope|nsubj|release release|nmod|END_ENTITY	Early release of mitochondrial cytochrome_c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer : Bcl-2 and Bcl-xL overexpression do not prevent early mitochondrial events but still depress caspase activity .
10639121	0	Bcl-2	22,27	cytochrome_c	50,62	Bcl-2	cytochrome c	596	54205	Gene	Gene	START_ENTITY|dep|induce induce|dobj|release release|amod|END_ENTITY	Proapoptotic BH3-only Bcl-2 family members induce cytochrome_c release , but not mitochondrial membrane potential loss , and do not directly modulate voltage-dependent anion channel activity .
10760520	0	Bcl-2	11,16	cytochrome_c	26,38	Bcl-2	cytochrome c	596	54205	Gene	Gene	Failure|nmod|START_ENTITY Failure|acl|block block|dobj|redistribution redistribution|amod|END_ENTITY	Failure of Bcl-2 to block cytochrome_c redistribution during TRAIL-induced apoptosis .
11085742	0	Bcl-2	61,66	cytochrome_c	20,32	Bcl-2	cytochrome c	596	54205	Gene	Gene	bid|compound|START_ENTITY regulated|nmod|bid regulated|nsubjpass|release release|amod|END_ENTITY	Granzyme_B-mediated cytochrome_c release is regulated by the Bcl-2 family members bid and Bax .
11489892	0	Bcl-2	138,143	cytochrome_c	91,103	Bcl-2	cytochrome c	596	54205	Gene	Gene	overexpress|xcomp|START_ENTITY cells|acl:relcl|overexpress release|nmod|cells release|amod|END_ENTITY	Unreliability of the cytochrome_c-enhanced green fluorescent fusion protein as a marker of cytochrome_c release in cells that overexpress Bcl-2 .
12951029	0	Bcl-2	0,5	cytochrome_c	41,53	Bcl-2	cytochrome c	596	54205	Gene	Gene	overexpression|compound|START_ENTITY inhibits|nsubj|overexpression inhibits|dobj|release release|amod|END_ENTITY	Bcl-2 and Bcl-xL overexpression inhibits cytochrome_c release , activation of multiple caspases , and virus release following coxsackievirus B3 infection .
17283155	0	Bcl-2	0,5	cytochrome_c	125,137	Bcl-2	cytochrome c	596	54205	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|gamma-radiation gamma-radiation|nmod|pathway pathway|acl:relcl|independent independent|nmod|release release|amod|END_ENTITY	Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome_c release .
9027314	0	Bcl-2	27,32	cytochrome_c	45,57	Bcl-2	cytochrome c	596	54205	Gene	Gene	apoptosis|nmod|START_ENTITY apoptosis|dep|release release|nmod|END_ENTITY	Prevention of apoptosis by Bcl-2 : release of cytochrome_c from mitochondria blocked .
9027315	0	Bcl-2	66,71	cytochrome_c	15,27	Bcl-2	cytochrome c	596	54205	Gene	Gene	regulation|compound|START_ENTITY site|nmod|regulation release|dep|site release|nmod|END_ENTITY	The release of cytochrome_c from mitochondria : a primary site for Bcl-2 regulation of apoptosis .
9268320	0	Bcl-2	0,5	cytochrome_c	66,78	Bcl-2	cytochrome c	596	54205	Gene	Gene	membrane|nsubj|START_ENTITY membrane|nmod|inactivation inactivation|nmod|END_ENTITY	Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome_c during Fas-mediated apoptosis .
9461218	0	Bcl-2	0,5	cytochrome_c	58,70	Bcl-2	cytochrome c	596	54205	Gene	Gene	prolongs|nsubj|START_ENTITY prolongs|nmod|release release|nmod|END_ENTITY	Bcl-2 prolongs cell survival after Bax-induced release of cytochrome_c .
9694346	0	Bcl-2	132,137	cytochrome_c	71,83	Bcl-2	cytochrome c	596	54205	Gene	Gene	proteins|compound|START_ENTITY expression|nmod|proteins absence|nmod|expression release|nmod|absence release|amod|END_ENTITY	Potassium deprivation-induced apoptosis of cerebellar granule neurons : cytochrome_c release in the absence of altered expression of Bcl-2 family proteins .
8182935	0	Bcl-2	14,19	granulocyte-macrophage_colony-stimulating_factor	86,134	Bcl-2	granulocyte-macrophage colony-stimulating factor	596	1437	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of Bcl-2 expression and apoptosis in acute_myeloblastic_leukaemia cells by granulocyte-macrophage_colony-stimulating_factor .
22461702	0	Bcl-2	51,56	insulin-like_growth_factor-1	14,42	Bcl-2	insulin-like growth factor-1	596	3479	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Intracellular insulin-like_growth_factor-1 induces Bcl-2 expression in airway epithelial cells .
22878411	0	Bcl-2	67,72	insulin-like_growth_factor-1	27,55	Bcl-2	insulin-like growth factor-1	12043(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY mediate|dobj|expression END_ENTITY|xcomp|mediate	Acute inflammation induces insulin-like_growth_factor-1 to mediate Bcl-2 and Muc5ac expression in airway epithelial cells .
15208671	0	Bcl-2	0,5	mTOR	78,82	Bcl-2	mTOR	596	21977(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY require|nsubj|phosphorylation require|dobj|END_ENTITY	Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt .
15505422	0	Bcl-2	0,5	mTOR	71,75	Bcl-2	mTOR	596	21977(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY predict|nsubj|levels predict|dobj|effects effects|nmod|inhibitors inhibitors|compound|END_ENTITY	Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian_carcinoma .
23108993	0	Bcl-2	85,90	mTOR	74,78	Bcl-2	mTOR	100009447(Tax:9986)	21977(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
25484022	0	Bcl-2	70,75	mTOR	88,92	Bcl-2	mTOR	596	21977(Tax:10090)	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|activation activation|compound|END_ENTITY	Lactate promotes resistance to glucose_starvation via upregulation of Bcl-2 mediated by mTOR activation .
26974552	0	Bcl-2	183,188	mTOR	62,66	Bcl-2	mTOR	596	21977(Tax:10090)	Gene	Gene	Down-Regulation|nmod|START_ENTITY Apoptosis|nmod|Down-Regulation Apoptosis|compound|END_ENTITY	Correction : Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal_Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability .
25435430	0	Bcl-2	15,20	miR-16	85,91	Bcl-2	miR-16	596	51573	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	miR-16 targets Bcl-2 in paclitaxel-resistant lung_cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis .
22121083	0	Bcl-2	18,23	miR-1915	0,8	Bcl-2	miR-1915	596	100302129	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal_carcinoma cells .
23152059	0	Bcl-2	16,21	miR-204	0,7	Bcl-2	miR-204	596	406987	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-204 targets Bcl-2 expression and enhances responsiveness of gastric_cancer .
25385144	0	Bcl-2	73,78	miR-210	65,72	Bcl-2	miR-210	596	406992	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1a / miR-210 / Bcl-2 pathway in colon_cancer cells .
24829923	0	Bcl-2	18,23	miR-34a	38,45	Bcl-2	miR-34a	596	407040	Gene	Gene	expression|compound|START_ENTITY expression|nmod|mediates mediates|amod|END_ENTITY	Downregulation of Bcl-2 expression by miR-34a mediates palmitate-induced Min6 cells apoptosis .
26091620	0	Bcl-2	128,133	miR-34a	9,16	Bcl-2	miR-34a	596	407040	Gene	Gene	neurotoxins|nmod|START_ENTITY enhanced|nmod|neurotoxins enhanced|nsubj|END_ENTITY	Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2 .
24606718	0	Bcl-2	87,92	miRNA21	57,64	Bcl-2	miRNA21	596	406991	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast_cancer cells .
26692938	0	Bcl-2	117,122	microRNA-1	14,24	Bcl-2	microRNA-1	24224(Tax:10116)	100314077(Tax:10116)	Gene	Gene	targeting|dobj|START_ENTITY hypoxia/re-oxygenation-induced|advcl|targeting hypoxia/re-oxygenation-induced|nsubj|Inhibition Inhibition|nmod|attenuates attenuates|amod|END_ENTITY	Inhibition of microRNA-1 attenuates hypoxia/re-oxygenation-induced apoptosis of cardiomyocytes by directly targeting Bcl-2 but not GADD45Beta .
15498114	0	Bcl-2	53,58	mitochondrial_ceramidase	0,24	Bcl-2	mitochondrial ceramidase	596	56624	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	mitochondrial_ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells , probably through its metabolite sphingosine-1-phosphate .
10219080	0	Bcl-2	18,23	nerve_growth_factor	36,55	Bcl-2	nerve growth factor	596	4803	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Activation of the Bcl-2 promoter by nerve_growth_factor is mediated by the p42/p44 MAPK cascade .
19375463	0	Bcl-2	0,5	nestin	66,72	Bcl-2	nestin	24224(Tax:10116)	25491(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Bcl-2 or bcl-XL gene therapy increases neural plasticity proteins nestin and c-fos expression in PC12 cells .
26960457	0	Bcl-2	30,35	p16	19,22	Bcl-2	p16	596	1029	Gene	Gene	Ki-67|appos|START_ENTITY Ki-67|appos|END_ENTITY	The role of Ki-67 , p16 , CD34 , Bcl-2 , cyclooxygenase-2 in the pathogenesis of proliferative_verrucous_leukoplakia .
10848600	0	Bcl-2	0,5	p27	39,42	Bcl-2	p27	596	10671	Gene	Gene	retards|nsubj|START_ENTITY retards|nmod|Kip1 Kip1|amod|END_ENTITY	Bcl-2 retards cell cycle entry through p27 -LRB- Kip1 -RRB- , pRB relative p130 , and altered E2F regulation .
16839413	0	Bcl-2	0,5	p27	44,47	Bcl-2	p27	596	3429	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|expressions expressions|amod|END_ENTITY	Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast_cancer .
18382684	0	Bcl-2	31,36	p27	0,3	Bcl-2	p27	12043(Tax:10090)	12576(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|deficiency deficiency|amod|END_ENTITY	p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell_lymphoma .
19447221	0	Bcl-2	0,5	p27	69,72	Bcl-2	p27	596	10671	Gene	Gene	blocks|nummod|START_ENTITY blocks|acl|induced induced|nmod|END_ENTITY	Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27 -LRB- Kip1 -RRB- - dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation .
9894613	0	Bcl-2	48,53	p27	139,142	Bcl-2	p27	596	3429	Gene	Gene	function|amod|START_ENTITY overcome|dobj|function overcome|dep|kinase kinase|dobj|END_ENTITY	Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed , but not normal , human fibroblasts .
16714293	0	Bcl-2	0,5	p38_MAPK	25,33	Bcl-2	p38 MAPK	12043(Tax:10090)	26416(Tax:10090)	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Bcl-2 Phosphorylation by p38_MAPK : identification of target sites and biologic consequences .
19676105	0	Bcl-2	156,161	p38_mitogen-activated_protein_kinase	86,122	Bcl-2	p38 mitogen-activated protein kinase	596	1432	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|amod|END_ENTITY	Curcumin-induced apoptosis in ovarian_carcinoma cells is p53-independent and involves p38_mitogen-activated_protein_kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling .
10037739	0	Bcl-2	46,51	p53	14,17	Bcl-2	p53	596	7157	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain .
10188857	0	Bcl-2	33,38	p53	4,7	Bcl-2	p53	596	7157	Gene	Gene	accumulation|compound|START_ENTITY over-expression|appos|accumulation over-expression|compound|END_ENTITY	Can p53 nuclear over-expression , Bcl-2 accumulation and PCNA status be of prognostic significance in high-risk superficial and invasive bladder_tumours ?
10329733	0	Bcl-2	37,42	p53	0,3	Bcl-2	p53	596	7157	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter suppresses|dobj|activation suppresses|nsubj|END_ENTITY	p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor .
10362119	0	Bcl-2	0,5	p53	36,39	Bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY related|nsubj|expression related|nmod|protein protein|compound|END_ENTITY	Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic_carcinoma .
10597302	0	Bcl-2	142,147	p53	195,198	Bcl-2	p53	596	7157	Gene	Gene	regulated|nmod|START_ENTITY pathways|acl:relcl|regulated Induction|nmod|pathways Bcl-XL|dep|Induction Bcl-XL|nmod|independent independent|nmod|END_ENTITY	Induction of apoptosis in U937 human leukemia cells by suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- proceeds through pathways that are regulated by Bcl-2 / Bcl-XL , c-Jun , and p21CIP1 , but independent of p53 .
10641752	0	Bcl-2	20,25	p53	7,10	Bcl-2	p53	596	7157	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Mutant p53 protein , Bcl-2 / Bax ratios and apoptosis in paediatric acute_lymphoblastic_leukaemia .
11044365	0	Bcl-2	0,5	p53	77,80	Bcl-2	p53	596	7157	Gene	Gene	START_ENTITY|parataxis|predicts predicts|dobj|sensitivity sensitivity|nmod|status status|compound|END_ENTITY	Bcl-2 / Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status .
11519857	0	Bcl-2	70,75	p53	29,32	Bcl-2	p53	596	7157	Gene	Gene	mutations|appos|START_ENTITY mutations|appos|accumulation accumulation|compound|END_ENTITY	TP53 gene mutations , nuclear p53 accumulation , expression of Waf/p21 , Bcl-2 , and CD95 -LRB- APO-1 / Fas -RRB- proteins are not prognostic factors in de novo glioblastoma multiforme .
11532334	0	Bcl-2	0,5	p53	72,75	Bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	blocks|nsubj|START_ENTITY blocks|nmod|suppression suppression|nmod|accumulation accumulation|compound|END_ENTITY	Bcl-2 blocks cisplatin-induced apoptosis by suppression of ERK-mediated p53 accumulation in B104 cells .
11694525	0	Bcl-2	99,104	p53	122,125	Bcl-2	p53	596	7157	Gene	Gene	ratio|compound|START_ENTITY ratio|nmod|PaCa-2 PaCa-2|compound|END_ENTITY	Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2 / Bax ratio in the p53 mutant pancreatic_cancer cell line MIA PaCa-2 .
11802199	0	Bcl-2	118,123	p53	113,116	Bcl-2	p53	596	7157	Gene	Gene	patients|dobj|START_ENTITY patients|acl|using using|dobj|expression expression|nmod|END_ENTITY	Molecular staging of colorectal_cancer in African-American and Caucasian patients using phenotypic expression of p53 , Bcl-2 , MUC-1 AND p27 -LRB- kip-1 -RRB- .
12100521	0	Bcl-2	0,5	p53	13,16	Bcl-2	p53	596	7157	Gene	Gene	disordered|advmod|START_ENTITY disordered|nsubj|iNOS iNOS|appos|expression expression|compound|END_ENTITY	Bcl-2 , iNOS , p53 and PCNA expression in normal , disordered proliferative , hyperplastic and malignant endometrium .
12541691	0	Bcl-2	1,6	p53	8,11	Bcl-2	p53	596	7157	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	-LSB- Bcl-2 , p53 expression and Epstein-Barr_virus infection in primary nasopharyngeal_carcinoma -RSB- .
14518224	0	Bcl-2	1,6	p53	96,99	Bcl-2	p53	596	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|inhibitors inhibitors|nmod|import import|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Bcl-2 inhibits p53-induced apoptosis after genotoxic damage by inhibitors of nuclear import of p53 -RSB- .
15390206	0	Bcl-2	73,78	p53	12,15	Bcl-2	p53	596	7157	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|Mutation Mutation|nmod|END_ENTITY	Mutation of p53 in head and neck_squamous_cell_carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis .
15647429	0	Bcl-2	10,15	p53	16,19	Bcl-2	p53	596	7157	Gene	Gene	ratio|dep|START_ENTITY ratio|compound|END_ENTITY	Increased Bcl-2 / p53 ratio in human osteoarthritic cartilage : a possible role in regulation of chondrocyte metabolism .
16297852	0	Bcl-2	0,5	p53	149,152	Bcl-2	p53	596	7157	Gene	Gene	J|amod|START_ENTITY protected|nsubj|J protected|nmod|apoptosis apoptosis|dep|role role|nmod|END_ENTITY	Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis : role of p53 in the ceramide response .
16473926	0	Bcl-2	21,26	p53	16,19	Bcl-2	p53	596	7157	Gene	Gene	index|dep|START_ENTITY index|compound|END_ENTITY	Relationship of p53 , Bcl-2 , Ki-67 index and E-cadherin expression in early invasive breast_cancers with comedonecrosis as an accelerated apoptosis .
16916556	0	Bcl-2	57,62	p53	45,48	Bcl-2	p53	596	7157	Gene	Gene	lymphoid_malignancy|compound|START_ENTITY mutant|appos|lymphoid_malignancy mutant|compound|END_ENTITY	TRAIL enhances efficacy of radiotherapy in a p53 mutant , Bcl-2 overexpressing lymphoid_malignancy .
17187363	0	Bcl-2	17,22	p53	4,7	Bcl-2	p53	596	7157	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	The p53 positive Bcl-2 negative phenotype is an independent marker of prognosis in breast_cancer .
17252199	0	Bcl-2	33,38	p53	19,22	Bcl-2	p53	596	7157	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen_receptor-positive breast_cancer cells .
17332930	0	Bcl-2	15,20	p53	90,93	Bcl-2	p53	596	7157	Gene	Gene	members|compound|START_ENTITY Involvement|nmod|members Involvement|dep|END_ENTITY	Involvement of Bcl-2 family members , phosphatidylinositol 3 ' - kinase/AKT and mitochondrial p53 in curcumin -LRB- diferulolylmethane -RRB- - induced apoptosis in prostate_cancer .
17352211	0	Bcl-2	63,68	p53	27,30	Bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY apoptosis|dobj|protein apoptosis|nsubj|protein protein|appos|END_ENTITY	Tumour suppressor protein -LRB- p53 -RRB- , apoptosis inhibiting protein -LRB- Bcl-2 -RRB- and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expressions in a rat pancreatic tumour model .
17465228	0	Bcl-2	20,25	p53	14,17	Bcl-2	p53	596	7157	Gene	Gene	Regulation|amod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of p53 - , Bcl-2 - and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells .
17536310	0	Bcl-2	46,51	p53	20,23	Bcl-2	p53	596	7157	Gene	Gene	Immunoreactivity|appos|START_ENTITY Immunoreactivity|nmod|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
18158619	0	Bcl-2	15,20	p53	48,51	Bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast_cancer cells .
18828269	0	Bcl-2	63,68	p53	58,61	Bcl-2	p53	596	7157	Gene	Gene	Bcl-XL|dep|START_ENTITY Bcl-XL|compound|END_ENTITY	Apoptosis and adenocarcinoma_of_the_cardia : expression of p53 , Bcl-2 , Bcl-XL , WAF1 , and fas proteins and association with characteristics of the tumors .
19360319	0	Bcl-2	42,47	p53	32,35	Bcl-2	p53	596	7157	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
19555669	0	Bcl-2	106,111	p53	99,102	Bcl-2	p53	596	7157	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Transcriptional down-regulation of Bcl-2 by vinorelbine : identification of a novel binding site of p53 on Bcl-2 promoter .
19555669	0	Bcl-2	35,40	p53	99,102	Bcl-2	p53	596	7157	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|dep|identification identification|nmod|site site|nmod|END_ENTITY	Transcriptional down-regulation of Bcl-2 by vinorelbine : identification of a novel binding site of p53 on Bcl-2 promoter .
21485723	0	Bcl-2	28,33	p53	40,43	Bcl-2	p53	596	7157	Gene	Gene	caspase-3|compound|START_ENTITY caspase-3|dep|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
22178939	0	Bcl-2	67,72	p53	50,53	Bcl-2	p53	12043(Tax:10090)	22060(Tax:10090)	Gene	Gene	Bax|compound|START_ENTITY Bax|compound|END_ENTITY	Purple_sweet_potato pigments scavenge ROS , reduce p53 and modulate Bcl-2 / Bax to inhibit irradiation-induced apoptosis in murine thymocytes .
23316052	0	Bcl-2	81,86	p53	153,156	Bcl-2	p53	596	7157	Gene	Gene	proteins|compound|START_ENTITY domain|nmod|proteins interactions|nmod|domain reveal|nsubj|interactions reveal|dobj|mechanism mechanism|nmod|pathways pathways|compound|END_ENTITY	Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways .
23316052	0	Bcl-2	81,86	p53	26,29	Bcl-2	p53	596	7157	Gene	Gene	proteins|compound|START_ENTITY domain|nmod|proteins domain|compound|END_ENTITY	Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways .
24223706	0	Bcl-2	25,30	p53	46,49	Bcl-2	p53	596	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Dihydromyricetin reduced Bcl-2 expression via p53 in human hepatoma HepG2 cells .
24342622	0	Bcl-2	53,58	p53	13,16	Bcl-2	p53	596	7157	Gene	Gene	proteins|compound|START_ENTITY analogues|nmod|proteins analogues|nsubj|Targeting Targeting|nmod|peptide peptide|compound|END_ENTITY	Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy .
24814047	0	Bcl-2	60,65	p53	17,20	Bcl-2	p53	596	7157	Gene	Gene	inhibit|dobj|START_ENTITY processing|acl|inhibit induces|dobj|processing induces|nsubj|END_ENTITY	Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage .
25404359	0	Bcl-2	40,45	p53	21,24	Bcl-2	p53	596	7157	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	Granzyme_B-Activated p53 Interacts with Bcl-2 To Promote Cytotoxic Lymphocyte-Mediated Apoptosis .
26303118	0	Bcl-2	91,96	p53	86,89	Bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mediates|appos|expression mediates|dep|cells cells|nmod|modulation modulation|nmod|END_ENTITY	Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53 , Bcl-2 , caspase-7 and caspase-3 protein expression .
26303118	0	Bcl-2	91,96	p53	86,89	Bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mediates|appos|expression mediates|dep|cells cells|nmod|modulation modulation|nmod|END_ENTITY	Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53 , Bcl-2 , caspase-7 and caspase-3 protein expression .
26431162	0	Bcl-2	92,97	p53	23,26	Bcl-2	p53	596	7157	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|inhibition inhibition|nsubj|effects effects|nmod|activation activation|compound|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
26819684	0	Bcl-2	110,115	p53	105,108	Bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	Levels|dep|START_ENTITY Levels|dep|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
27064014	0	Bcl-2	201,206	p53	225,228	Bcl-2	p53	596	7157	Gene	Gene	levels|compound|START_ENTITY levels|appos|expression expression|compound|END_ENTITY	Isololiolide , a carotenoid metabolite isolated from the brown_alga_Cystoseira_tamariscifolia , is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation , decreased Bcl-2 levels , increased p53 expression and PARP cleavage .
7734290	0	Bcl-2	0,5	p53	59,62	Bcl-2	p53	596	7157	Gene	Gene	protein|amod|START_ENTITY protein|dep|factor factor|acl|correlated correlated|nmod|END_ENTITY	Bcl-2 protein : a prognostic factor inversely correlated to p53 in non-small-cell_lung_cancer .
7768985	0	Bcl-2	0,5	p53	84,87	Bcl-2	p53	596	7157	Gene	Gene	protooncogene|nsubj|START_ENTITY protooncogene|dep|containing containing|dobj|END_ENTITY	Bcl-2 protooncogene expression in cervical_carcinoma cell lines containing inactive p53 .
8133533	0	Bcl-2	4,9	p53	62,65	Bcl-2	p53	596	7157	Gene	Gene	protein|compound|START_ENTITY protein|dep|indicator indicator|acl|related related|nmod|protein protein|compound|END_ENTITY	The Bcl-2 protein : a prognostic indicator strongly related to p53 protein in lymph node-negative breast_cancer patients .
8620501	0	Bcl-2	124,129	p53	105,108	Bcl-2	p53	596	7157	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Hypersensitivity of human testicular_tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax : Bcl-2 ratio .
8621251	0	Bcl-2	23,28	p53	73,76	Bcl-2	p53	596	7157	Gene	Gene	expression|nmod|START_ENTITY expression|acl|carrying carrying|dobj|END_ENTITY	Frequent expression of Bcl-2 in renal-cell_carcinomas carrying wild-type p53 .
8690754	0	Bcl-2	0,5	p53	41,44	Bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	Bcl-2 expression and allelic loss of the p53 gene in gastric_carcinomas .
8959332	0	Bcl-2	91,96	p53	14,17	Bcl-2	p53	596	7157	Gene	Gene	inhibited|nmod|START_ENTITY apoptosis|acl:relcl|inhibited induces|dobj|apoptosis induces|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein .
8982242	0	Bcl-2	62,67	p53	69,72	Bcl-2	p53	596	7157	Gene	Gene	oncoproteins|dep|START_ENTITY oncoproteins|dep|END_ENTITY	Detection of apoptotic cells and expression of Ki-67 antigen , Bcl-2 , p53 oncoproteins in human parathyroid_adenoma .
9108419	0	Bcl-2	29,34	p53	67,70	Bcl-2	p53	596	7157	Gene	Gene	Expression|nmod|START_ENTITY correlate|nsubj|Expression correlate|nmod|status status|compound|END_ENTITY	Expression and regulation of Bcl-2 , Bcl-xl , and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute_lymphoblastic_leukemia .
9413034	0	Bcl-2	14,19	p53	89,92	Bcl-2	p53	596	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|accumulation accumulation|dep|END_ENTITY	Expression of Bcl-2 in human breast_cancer : correlation between hormone receptor status , p53 protein accumulation and DNA strand breaks associated with apoptosis .
9419967	0	Bcl-2	0,5	p53	15,18	Bcl-2	p53	596	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|import import|compound|END_ENTITY	Bcl-2 inhibits p53 nuclear import following DNA damage .
9614375	0	Bcl-2	14,19	p53	68,71	Bcl-2	p53	596	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|comparison comparison|nmod|END_ENTITY	Expression of Bcl-2 in lung_neuroendocrine_tumours : comparison with p53 .
9667660	0	Bcl-2	0,5	p53	43,46	Bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|association association|nmod|END_ENTITY	Bcl-2 protein expression : association with p53 and prognosis in colorectal_cancer .
9754764	0	Bcl-2	0,5	p53	141,144	Bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY associated|nsubj|expression associated|nmod|apoptosis apoptosis|nmod|clear_cell_adenocarcinomas clear_cell_adenocarcinomas|nmod|vagina vagina|acl|expressing expressing|dobj|END_ENTITY	Bcl-2 protein expression associated with resistance to apoptosis in clear_cell_adenocarcinomas of the vagina and cervix expressing wild-type p53 .
9823951	0	Bcl-2	137,142	p53	108,111	Bcl-2	p53	596	7157	Gene	Gene	expression|compound|START_ENTITY phenotype|nmod|expression phenotype|compound|END_ENTITY	Sensitivity to Fas-mediated apoptosis in pediatric acute_lymphoblastic_leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression .
15359646	0	Bcl-2	103,108	par-4	73,78	Bcl-2	par-4	596	5074	Gene	Gene	down-regulate|dobj|START_ENTITY fails|ccomp|down-regulate fails|nsubj|Prostate-apoptosis-response-gene-4 Prostate-apoptosis-response-gene-4|dep|END_ENTITY	In the erythroleukemic_cell_line_HEL Prostate-apoptosis-response-gene-4 -LRB- par-4 -RRB- fails to down-regulate Bcl-2 and to promote apoptosis .
15016329	0	Bcl-2	21,26	phosphatase_2A	38,52	Bcl-2	phosphatase 2A	596	5524	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Dephosphorylation of Bcl-2 by protein phosphatase_2A results in apoptosis resistance .
7609638	0	Bcl-2	54,59	prion_protein	13,26	Bcl-2	prion protein	596	5621	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	The cellular prion_protein -LRB- PrP -RRB- selectively binds to Bcl-2 in the yeast two-hybrid system .
9344576	0	Bcl-2	24,29	prion_protein	96,109	Bcl-2	prion protein	596	5621	Gene	Gene	level|amod|START_ENTITY flupirtine|nmod|level Effect|nmod|flupirtine treated|nsubj|Effect treated|nmod|fragment fragment|amod|vitro vitro|nmod|END_ENTITY	Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion_protein fragment -LRB- PrP106-126 -RRB- .
12242728	0	Bcl-2	0,5	transforming_growth_factor-beta	51,82	Bcl-2	transforming growth factor-beta	596	7040	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|effect effect|nmod|END_ENTITY	Bcl-2 antagonizes the combined apoptotic effect of transforming_growth_factor-beta and dihydrotestosterone in prostate_cancer cells .
11243465	0	Bcl-2	136,141	transforming_growth_factor_beta	14,45	Bcl-2	transforming growth factor beta	596	7040	Gene	Gene	role|nmod|START_ENTITY Inhibition|dep|role Inhibition|nmod|END_ENTITY	Inhibition of transforming_growth_factor_beta signaling in MCF-7 cells results in resistance to tumor_necrosis_factor_alpha : a role for Bcl-2 .
21988644	0	Bcl-2	122,127	tumor_necrosis_factor_related_apoptosis-inducing_ligand	48,103	Bcl-2	tumor necrosis factor related apoptosis-inducing ligand	596	8743	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of lentivirus-mediated expression of tumor_necrosis_factor_related_apoptosis-inducing_ligand and shRNA against Bcl-2 on the growth of lymphoma cells .
10744622	0	Bcl-2	0,5	vascular_endothelial_growth_factor	65,99	Bcl-2	vascular endothelial growth factor	596	7422	Gene	Gene	overexpression|compound|START_ENTITY act|nsubj|overexpression act|nmod|expression expression|compound|END_ENTITY	Bcl-2 overexpression and hypoxia synergistically act to modulate vascular_endothelial_growth_factor expression and in vivo angiogenesis in a breast_carcinoma line .
23983126	0	Bcl-2-associated_athanogene_domain_3	115,151	BAG3	153,157	Bcl-2-associated athanogene domain 3	BAG3	9531	9531	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The natural compound cantharidin induces cancer cell death through inhibition of heat_shock_protein_70 -LRB- HSP70 -RRB- and Bcl-2-associated_athanogene_domain_3 -LRB- BAG3 -RRB- expression by blocking heat_shock_factor_1 -LRB- HSF1 -RRB- binding to promoters .
12351720	0	Bcl-2-associated_death_protein	14,44	Akt	69,72	Bcl-2-associated death protein	Akt	64639(Tax:10116)	24185(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Bcl-2-associated_death_protein and counter-response of Akt within cell populations during seizure-induced neuronal_death .
17546604	0	Bcl-2_associated-athanogene-1	17,46	Bag-1	48,53	Bcl-2 associated-athanogene-1	Bag-1	573	573	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for Bcl-2_associated-athanogene-1 -LRB- Bag-1 -RRB- in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes .
24459141	0	Bcl-3	50,55	B_cell_Leukemia_3	31,48	Bcl-3	B cell Leukemia 3	602	602	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Inhibition of transcription by B_cell_Leukemia_3 -LRB- Bcl-3 -RRB- protein requires interaction with nuclear factor kB -LRB- NF-kB -RRB- p50 .
12153169	0	Bcl-3	0,5	IgH	6,9	Bcl-3	IgH	602	3492	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Bcl-3 / IgH translocation -LRB- 14 ; 19 -RRB- -LRB- q32 ; q13 -RRB- in non-Hodgkin 's _ lymphomas .
17963943	0	Bcl-3	111,116	LMP1	31,35	Bcl-3	LMP1	602	9260	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The latent membrane protein 1 -LRB- LMP1 -RRB- encoded by Epstein-Barr_virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB .
18796561	0	Bcl-3	84,89	NF-kappaB	52,61	Bcl-3	NF-kappaB	602	4790	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Oxidative , multistep activation of the noncanonical NF-kappaB pathway via disulfide Bcl-3 / p50 complex .
12907458	0	Bcl-3	16,21	TNF-alpha	55,64	Bcl-3	TNF-alpha	602	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages .
24044922	0	Bcl-3	0,5	Tax	18,21	Bcl-3	Tax	602	1491938(Tax:11908)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Bcl-3 , induced by Tax and HTLV-1 , inhibits NF-kB activation and promotes autophagy .
8649843	0	Bcl-3	52,57	retinoblastoma	18,32	Bcl-3	retinoblastoma	602	5925	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Activation of the retinoblastoma gene expression by Bcl-3 : implication for muscle cell differentiation .
23052175	0	Bcl-6	86,91	CD10	80,84	Bcl-6	CD10	604	4311	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	A unique case of blastoid variant of mantle_cell_lymphoma with an aberrant CD5 - / CD10 + / Bcl-6 + / CD56 + immunophenotype : a case report .
25436971	0	Bcl-6	63,68	ICOS	45,49	Bcl-6	ICOS	604	29851	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	A p85a-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells .
16423395	0	Bcl-6	39,44	Mad1	0,4	Bcl-6	Mad1	12053(Tax:10090)	17119(Tax:10090)	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Mad1 is a transcriptional repressor of Bcl-6 .
11278245	0	Bcl-B	0,5	Bax	75,78	Bcl-B	Bax	10017	581	Gene	Gene	START_ENTITY|appos|member member|acl:relcl|binds binds|dobj|END_ENTITY	Bcl-B , a novel Bcl-2 family member that differentially binds and regulates Bax and Bak .
18178565	0	Bcl-B	79,84	Bax	27,30	Bcl-B	Bax	10017	581	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1 .
11278245	0	Bcl-B	0,5	Bcl-2	15,20	Bcl-B	Bcl-2	10017	596	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Bcl-B , a novel Bcl-2 family member that differentially binds and regulates Bax and Bak .
10537354	0	Bcl-X	7,12	Bcl-2	0,5	Bcl-X	Bcl-2	598	596	Gene	Gene	expression|nsubj|START_ENTITY expression|advmod|END_ENTITY	Bcl-2 , Bcl-X , Bax , and Bak expression in short - and long-lived patients with diffuse large B-cell_lymphomas .
12963020	0	Bcl-XL	20,26	Apaf-1	70,76	Bcl-XL	Apaf-1	598	317	Gene	Gene	region|amod|START_ENTITY Identification|nmod|region Identification|nmod|END_ENTITY	Identification of a Bcl-XL binding region within the ATPase domain of Apaf-1 .
9539746	0	Bcl-XL	0,6	Apaf-1	22,28	Bcl-XL	Apaf-1	598	317	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation .
7834748	0	Bcl-XL	33,39	Bad	0,3	Bcl-XL	Bad	598	572	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Bad , a heterodimeric partner for Bcl-XL and Bcl-2 , displaces Bax and promotes cell death .
10049709	0	Bcl-XL	91,97	Bax	56,59	Bcl-XL	Bax	598	581	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|state state|nmod|END_ENTITY	Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl-XL .
12198137	0	Bcl-XL	0,6	Bax	113,116	Bcl-XL	Bax	598	581	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|change change|acl|interacting interacting|nmod|END_ENTITY	Bcl-XL protects BimEL-induced Bax conformational change and cytochrome_C release independent of interacting with Bax or BimEL .
12198137	0	Bcl-XL	0,6	Bax	30,33	Bcl-XL	Bax	598	581	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|change change|amod|conformational conformational|amod|END_ENTITY	Bcl-XL protects BimEL-induced Bax conformational change and cytochrome_C release independent of interacting with Bax or BimEL .
15698865	0	Bcl-XL	17,23	Bax	12,15	Bcl-XL	Bax	598	581	Gene	Gene	ratio|compound|START_ENTITY Increase|dep|ratio Increase|nmod|END_ENTITY	Increase of Bax / Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line .
16061221	0	Bcl-XL	20,26	Bax	43,46	Bcl-XL	Bax	598	581	Gene	Gene	domains|nmod|START_ENTITY involved|nsubjpass|domains involved|nmod|antagonism antagonism|amod|END_ENTITY	Distinct domains of Bcl-XL are involved in Bax and Bad antagonism and in apoptosis inhibition .
17880809	0	Bcl-XL	77,83	Bax	41,44	Bcl-XL	Bax	598	581	Gene	Gene	Bcl-2|dep|START_ENTITY proteins|appos|Bcl-2 proteins|amod|proapoptotic proapoptotic|dep|END_ENTITY	-LSB- Analysis of intracellular proapoptotic -LRB- Bax , Bak -RRB- and antiapoptotic -LRB- Bcl-2 , Bcl-XL -RRB- proteins expression in thyrocytes from young patients with immune and non-immune thyroid_disorders -RSB- .
18547146	0	Bcl-XL	0,6	Bax	60,63	Bcl-XL	Bax	598	581	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|competing competing|nmod|END_ENTITY	Bcl-XL inhibits membrane permeabilization by competing with Bax .
22892098	0	Bcl-XL	77,83	Bax	54,57	Bcl-XL	Bax	598	581	Gene	Gene	dissociating|nmod|START_ENTITY dissociating|dobj|END_ENTITY	L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL .
7834748	0	Bcl-XL	33,39	Bax	61,64	Bcl-XL	Bax	598	581	Gene	Gene	partner|nmod|START_ENTITY Bad|appos|partner displaces|nsubj|Bad displaces|dobj|END_ENTITY	Bad , a heterodimeric partner for Bcl-XL and Bcl-2 , displaces Bax and promotes cell death .
8798452	0	Bcl-XL	121,127	Bax	0,3	Bcl-XL	Bax	598	581	Gene	Gene	heterodimerization|nmod|START_ENTITY death|nmod|heterodimerization antagonize|nmod|death antagonize|nsubj|END_ENTITY	Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL .
8798452	0	Bcl-XL	19,25	Bax	0,3	Bcl-XL	Bax	598	581	Gene	Gene	antagonize|dobj|START_ENTITY antagonize|nsubj|END_ENTITY	Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL .
10597302	0	Bcl-XL	148,154	Bcl-2	142,147	Bcl-XL	Bcl-2	598	596	Gene	Gene	START_ENTITY|dep|Induction Induction|nmod|pathways pathways|acl:relcl|regulated regulated|nmod|END_ENTITY	Induction of apoptosis in U937 human leukemia cells by suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- proceeds through pathways that are regulated by Bcl-2 / Bcl-XL , c-Jun , and p21CIP1 , but independent of p53 .
15570009	0	Bcl-XL	89,95	Bcl-2	27,32	Bcl-XL	Bcl-2	598	596	Gene	Gene	oligonucleotides|amod|START_ENTITY Bcl-2|dep|oligonucleotides Trastuzumab|nmod|Bcl-2 Trastuzumab|dobj|expression expression|compound|END_ENTITY	Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2 / Bcl-XL bispecific antisense oligonucleotides in HER-2 gene -- amplified breast_cancer cells .
15570009	0	Bcl-XL	89,95	Bcl-2	83,88	Bcl-XL	Bcl-2	598	596	Gene	Gene	oligonucleotides|amod|START_ENTITY END_ENTITY|dep|oligonucleotides	Trastuzumab down-regulates Bcl-2 expression and potentiates apoptosis induction by Bcl-2 / Bcl-XL bispecific antisense oligonucleotides in HER-2 gene -- amplified breast_cancer cells .
16928273	0	Bcl-XL	0,6	Bcl-2	73,78	Bcl-XL	Bcl-2	598	596	Gene	Gene	different|nsubj|START_ENTITY different|nmod|END_ENTITY	Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast_cancer cell line .
17173063	0	Bcl-XL	114,120	Bcl-2	108,113	Bcl-XL	Bcl-2	598	596	Gene	Gene	ABT-737|compound|START_ENTITY ABT-737|compound|END_ENTITY	` Seed ' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2 / Bcl-XL inhibitor ABT-737 .
17384650	0	Bcl-XL	7,13	Bcl-2	87,92	Bcl-XL	Bcl-2	598	596	Gene	Gene	associated|nsubjpass|START_ENTITY associated|advcl|decrease decrease|nsubj|levels levels|compound|END_ENTITY	Mcl-1 , Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2 , AP-2 and MITF levels decrease during progression of melanoma .
18056200	0	Bcl-XL	10,16	Bcl-2	4,9	Bcl-XL	Bcl-2	598	596	Gene	Gene	ABT-737|amod|START_ENTITY sensitizes|nsubj|ABT-737 END_ENTITY|parataxis|sensitizes	The Bcl-2 / Bcl-XL family inhibitor ABT-737 sensitizes ovarian_cancer cells to carboplatin .
21955141	0	Bcl-XL	10,16	Bcl-2	4,9	Bcl-XL	Bcl-2	598	596	Gene	Gene	ABT-737|amod|START_ENTITY promotes|nsubj|ABT-737 END_ENTITY|parataxis|promotes	The Bcl-2 / Bcl-XL inhibitor ABT-737 promotes death of retinoblastoma_cancer cells .
22002102	0	Bcl-XL	108,114	Bcl-2	102,107	Bcl-XL	Bcl-2	598	596	Gene	Gene	ABT-737|amod|START_ENTITY ABT-737|amod|/ /|amod|END_ENTITY	p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2 / Bcl-XL inhibitor ABT-737 .
23798675	0	Bcl-XL	128,134	Bcl-2	107,112	Bcl-XL	Bcl-2	598	596	Gene	Gene	START_ENTITY|nsubj|apoptosis apoptosis|nmod|cells cells|nmod|regulation regulation|nmod|members members|amod|END_ENTITY	CXCR4 chemokine receptor signaling induces apoptosis in acute_myeloid_leukemia cells via regulation of the Bcl-2 family members Bcl-XL , Noxa , and Bak .
24454684	0	Bcl-XL	16,22	Bcl-2	10,15	Bcl-XL	Bcl-2	598	596	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Targeting Bcl-2 / Bcl-XL induces antitumor activity in uveal_melanoma patient-derived xenografts .
24616095	0	Bcl-XL	43,49	Bcl-2	69,74	Bcl-XL	Bcl-2	598	596	Gene	Gene	protein|amod|START_ENTITY binds|nsubj|protein binds|dobj|region region|compound|END_ENTITY	After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization .
25726913	0	Bcl-XL	111,117	Bcl-2	105,110	Bcl-XL	Bcl-2	598	596	Gene	Gene	expression|amod|START_ENTITY expression|amod|/ /|amod|END_ENTITY	Lewis y enhances CAM-DR in ovarian_cancer cells by activating the FAK signaling pathway and upregulating Bcl-2 / Bcl-XL expression .
22892098	0	Bcl-XL	77,83	DJ-1	13,17	Bcl-XL	DJ-1	598	11315	Gene	Gene	dissociating|nmod|START_ENTITY promotes|advcl|dissociating promotes|nsubj|END_ENTITY	L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL .
11278399	0	Bcl-XL	0,6	Ets2	179,183	Bcl-XL	Ets2	598	2114	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Bcl-XL expression correlates with primary macrophage differentiation , activation of functional competence , and survival and results from synergistic transcriptional activation by Ets2 and PU .1 .
17869087	0	Bcl-XL	123,129	JNK	148,151	Bcl-XL	JNK	24888(Tax:10116)	116554(Tax:10116)	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	Piceatannol attenuates hydrogen-peroxide - and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK .
21567405	0	Bcl-XL	63,69	clusterin	14,23	Bcl-XL	clusterin	598	1191	Gene	Gene	interacting|nmod|START_ENTITY apoptosis|advcl|interacting apoptosis|nsubj|mediates mediates|compound|END_ENTITY	Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain .
11406282	0	Bcl-XL	42,48	zfBLP1	32,38	Bcl-XL	zfBLP1	114401(Tax:7955)	114401(Tax:7955)	Gene	Gene	homologue|amod|START_ENTITY END_ENTITY|appos|homologue	Cloning and characterization of zfBLP1 , a Bcl-XL homologue from the zebrafish , Danio_rerio .
11262395	0	Bcl-rambo	0,9	Bcl-2	19,24	Bcl-rambo	Bcl-2	23786	596	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Bcl-rambo , a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension .
25414595	0	Bcl-w	80,85	MiR-133b	0,8	Bcl-w	MiR-133b	599	442890	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-133b regulates bladder_cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1 .
22969914	0	Bcl-w	62,67	miR-497	0,7	Bcl-w	miR-497	599	574456	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	miR-497 induces apoptosis of breast_cancer cells by targeting Bcl-w .
10679744	0	Bcl-x	22,27	Bcl-2	0,5	Bcl-x	Bcl-2	598	596	Gene	Gene	ratios|amod|START_ENTITY END_ENTITY|dep|ratios	Bcl-2 : bax and bcl-2 : Bcl-x ratios by image cytometric quantitation of immunohistochemical expression in ovarian_carcinoma : correlation with prognosis .
21472231	0	Bcl-x	137,142	Bcl-2	116,121	Bcl-x	Bcl-2	598	596	Gene	Gene	Bak|dep|START_ENTITY apoptotic|appos|Bak apoptotic|dep|Immunoexpression Immunoexpression|nmod|family family|compound|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
21472231	0	Bcl-x	137,142	Bcl-2	130,135	Bcl-x	Bcl-2	598	596	Gene	Gene	Bak|dep|START_ENTITY Bak|compound|END_ENTITY	The intrinsic apoptotic signaling pathway in gastric_adenocarcinomas of Brazilian patients : Immunoexpression of the Bcl-2 family -LRB- Bcl-2 , Bcl-x , Bak , Bax , Bad -RRB- determined by tissue_microarray analysis .
9317114	0	Bcl-x	140,145	Bcl-2	134,139	Bcl-x	Bcl-2	598	596	Gene	Gene	expression|amod|START_ENTITY expression|amod|/ /|amod|END_ENTITY	B cell receptor cross-linking prevents Fas-induced cell death by inactivating the IL-1_beta-converting_enzyme protease and regulating Bcl-2 / Bcl-x expression .
15625014	0	Bcl-x	38,43	IL-6	47,51	Bcl-x	IL-6	598	3569	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of alternative splicing of Bcl-x by IL-6 , GM-CSF and TPA .
10482545	0	Bcl-x	13,18	NF-kappaB	83,92	Bcl-x	NF-kappaB	12048(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|type type|dep|END_ENTITY	Induction of Bcl-x -LRB- L -RRB- expression by human T-cell_leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax .
18663000	0	Bcl-x	38,43	RBM25	22,27	Bcl-x	RBM25	598	58517	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5 ' splice site selection .
26943323	0	Bcl-xL	72,78	ATM	20,23	Bcl-xL	ATM	12048(Tax:10090)	11920(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	PACS-2 mediates the ATM and NF-kB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage .
10773825	0	Bcl-xL	0,6	Apaf-1	40,46	Bcl-xL	Apaf-1	598	317	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|function function|nmod|END_ENTITY	Bcl-xL does not inhibit the function of Apaf-1 .
14617792	0	Bcl-xL	43,49	Apaf-1	94,100	Bcl-xL	Apaf-1	598	317	Gene	Gene	activating|nsubj|START_ENTITY activating|dobj|expression expression|amod|factor-1 factor-1|dep|END_ENTITY	Rituximab -LRB- anti-CD20 -RRB- selectively modifies Bcl-xL and apoptosis protease activating factor-1 -LRB- Apaf-1 -RRB- expression and sensitizes human non-Hodgkin 's _ lymphoma B cell lines to paclitaxel-induced apoptosis .
10949025	0	Bcl-xL	53,59	Aven	0,4	Bcl-xL	Aven	598	57099	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Aven , a novel inhibitor of caspase activation , binds Bcl-xL and Apaf-1 .
20619636	0	Bcl-xL	56,62	Aven	0,4	Bcl-xL	Aven	598	57099	Gene	Gene	stabilising|dobj|START_ENTITY blocks|advcl|stabilising blocks|nsubj|END_ENTITY	Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL .
15782132	0	Bcl-xL	72,78	Bax	66,69	Bcl-xL	Bax	598	581	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity .
15983241	0	Bcl-xL	0,6	Bax	30,33	Bcl-xL	Bax	24888(Tax:10116)	24887(Tax:10116)	Gene	Gene	transfer|compound|START_ENTITY inhibits|nsubj|transfer inhibits|dobj|translocation translocation|compound|END_ENTITY	Bcl-xL gene transfer inhibits Bax translocation and prolongs cardiac cold preservation time in rats .
17331788	0	Bcl-xL	179,185	Bax	45,48	Bcl-xL	Bax	24888(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY suberoylanilide_hydroxamic_acid|nmod|expression induced|nmod|suberoylanilide_hydroxamic_acid apoptosis|acl|induced activation|nmod|apoptosis activation|compound|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
17519046	0	Bcl-xL	143,149	Bax	73,76	Bcl-xL	Bax	598	581	Gene	Gene	modulate|nmod|START_ENTITY modulate|nsubj|N-terminus N-terminus|appos|helices helices|nmod|END_ENTITY	The N-terminus and alpha-5 , alpha-6 helices of the pro-apoptotic protein Bax , modulate functional interactions with the anti-apoptotic protein Bcl-xL .
18636161	0	Bcl-xL	34,40	Bax	62,65	Bcl-xL	Bax	598	581	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
18698495	0	Bcl-xL	75,81	Bax	68,71	Bcl-xL	Bax	598	581	Gene	Gene	ratios|amod|START_ENTITY END_ENTITY|nmod|ratios	Tanshinone_IIA inhibits human breast_cancer cells through increased Bax to Bcl-xL ratios .
19427863	0	Bcl-xL	26,32	Bax	44,47	Bcl-xL	Bax	598	581	Gene	Gene	neutralizes|dobj|START_ENTITY neutralizes|xcomp|promote promote|dobj|activation activation|compound|END_ENTITY	BimL directly neutralizes Bcl-xL to promote Bax activation during UV-induced apoptosis .
23954445	0	Bcl-xL	27,33	Bax	70,73	Bcl-xL	Bax	598	581	Gene	Gene	knock-down|nmod|START_ENTITY induces|nsubj|knock-down induces|nmod|activation activation|compound|END_ENTITY	Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic_cancer cells .
26504757	0	Bcl-xL	25,31	Bax	20,23	Bcl-xL	Bax	598	581	Gene	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Doxorubicin Changes Bax / Bcl-xL Ratio , Caspase-8_and_9 in Breast_Cancer Cells .
12046686	0	Bcl-xL	7,13	Bcl-2	0,5	Bcl-xL	Bcl-2	598	596	Gene	Gene	regulate|nsubj|START_ENTITY regulate|advmod|END_ENTITY	Bcl-2 , Bcl-xL and c-FLIP -LRB- L -RRB- potentially regulate the susceptibility of human peripheral blood monocyte-derived dendritic cells to cell death at different developmental stages .
17331788	0	Bcl-xL	179,185	Bcl-2	173,178	Bcl-xL	Bcl-2	24888(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
18006518	0	Bcl-xL	0,6	Bcl-2	98,103	Bcl-xL	Bcl-2	598	596	Gene	Gene	forms|nsubj|START_ENTITY forms|parataxis|implications implications|nmod|dimerization dimerization|nmod|proteins proteins|compound|END_ENTITY	Bcl-xL forms two distinct homodimers at non-ionic detergents : implications in the dimerization of Bcl-2 family proteins .
18698039	0	Bcl-xL	59,65	Bcl-2	53,58	Bcl-xL	Bcl-2	598	596	Gene	Gene	modulation|amod|START_ENTITY induction|dep|modulation induction|nmod|signals signals|nmod|END_ENTITY	Gefitinib induction of in vivo detectable signals by Bcl-2 / Bcl-xL modulation of inositol_trisphosphate_receptor_type_3 .
18758060	0	Bcl-xL	113,119	Bcl-2	74,79	Bcl-xL	Bcl-2	598	596	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|action action|nmod|B-cell_lymphoma_2 B-cell_lymphoma_2|appos|END_ENTITY	Differential regulation of the antiapoptotic action of B-cell_lymphoma_2 -LRB- Bcl-2 -RRB- and B-cell_lymphoma extra long -LRB- Bcl-xL -RRB- by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 1-involved pathway in neuroglioma cells .
19088028	0	Bcl-xL	104,110	Bcl-2	98,103	Bcl-xL	Bcl-2	598	596	Gene	Gene	inhibitor|amod|START_ENTITY expressing|dep|inhibitor expressing|nmod|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
19934311	0	Bcl-xL	118,124	Bcl-2	112,117	Bcl-xL	Bcl-2	598	596	Gene	Gene	upregulation|compound|START_ENTITY upregulation|amod|END_ENTITY	Disruption of sphingosine_1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2 / Bcl-xL upregulation .
21393385	0	Bcl-xL	136,142	Bcl-2	119,124	Bcl-xL	Bcl-2	598	596	Gene	Gene	reveals|nmod|START_ENTITY reveals|dobj|regulation regulation|nmod|bad bad|appos|protein protein|nmod|family family|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21393385	0	Bcl-xL	136,142	Bcl-2	4,9	Bcl-xL	Bcl-2	598	596	Gene	Gene	reveals|nmod|START_ENTITY reveals|nsubj|domain domain|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
22608393	0	Bcl-xL	61,67	Bcl-2	55,60	Bcl-xL	Bcl-2	598	596	Gene	Gene	antagonists|amod|START_ENTITY /|dobj|antagonists /|nsubj|Pyrazole Pyrazole|nmod|END_ENTITY	Pyrazole and pyrimidine_phenylacylsulfonamides as dual Bcl-2 / Bcl-xL antagonists .
22608961	0	Bcl-xL	63,69	Bcl-2	57,62	Bcl-xL	Bcl-2	598	596	Gene	Gene	antagonists|amod|START_ENTITY /|dobj|antagonists /|nsubj|Identification Identification|nmod|series series|nmod|END_ENTITY	Identification of a phenylacylsulfonamide series of dual Bcl-2 / Bcl-xL antagonists .
22747598	0	Bcl-xL	39,45	Bcl-2	33,38	Bcl-xL	Bcl-2	598	596	Gene	Gene	inhibitors|amod|START_ENTITY design|dep|inhibitors design|nmod|END_ENTITY	Structure-based design of potent Bcl-2 / Bcl-xL inhibitors with strong in vivo antitumor activity .
23375957	0	Bcl-xL	10,16	Bcl-2	4,9	Bcl-xL	Bcl-2	598	596	Gene	Gene	BH3I-2|amod|START_ENTITY affects|nsubj|BH3I-2 END_ENTITY|parataxis|affects	The Bcl-2 / Bcl-xL inhibitor BH3I-2 ' affects the dynamics and subcellular localization of sumoylated proteins .
23429261	0	Bcl-xL	100,106	Bcl-2	94,99	Bcl-xL	Bcl-2	598	596	Gene	Gene	ABT-737|amod|START_ENTITY ABT-737|dep|effects effects|nmod|END_ENTITY	pRb/E2F -1 - mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2 / Bcl-xL inhibitor ABT-737 .
23448298	0	Bcl-xL	38,44	Bcl-2	32,37	Bcl-xL	Bcl-2	598	596	Gene	Gene	inhibitor|amod|START_ENTITY /|dobj|inhibitor /|nsubj|END_ENTITY	A potent and highly efficacious Bcl-2 / Bcl-xL inhibitor .
23475955	0	Bcl-xL	6,12	Bcl-2	0,5	Bcl-xL	Bcl-2	598	596	Gene	Gene	inhibition|compound|START_ENTITY increases|nsubj|inhibition END_ENTITY|parataxis|increases	Bcl-2 / Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic_tumor models .
24058878	0	Bcl-xL	32,38	Bcl-2	26,31	Bcl-xL	Bcl-2	598	596	Gene	Gene	antagonist|dep|START_ENTITY END_ENTITY|dep|antagonist	ABT-737 , a small molecule Bcl-2 / Bcl-xL antagonist , increases antimitotic-mediated apoptosis in human prostate_cancer cells .
24881567	0	Bcl-xL	42,48	Bcl-2	36,41	Bcl-xL	Bcl-2	598	596	Gene	Gene	inhibitors|nsubj|START_ENTITY Towards|parataxis|inhibitors Towards|nmod|END_ENTITY	Towards the next generation of dual Bcl-2 / Bcl-xL inhibitors .
26008975	0	Bcl-xL	29,35	Bcl-2	23,28	Bcl-xL	Bcl-2	598	596	Gene	Gene	overcomes|nsubj|START_ENTITY inhibition|parataxis|overcomes inhibition|nmod|END_ENTITY	Combined inhibition of Bcl-2 / Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo .
26474387	0	Bcl-xL	35,41	Bcl-2	29,34	Bcl-xL	Bcl-2	598	596	Gene	Gene	inhibition|nsubj|START_ENTITY synergizes|parataxis|inhibition synergizes|nmod|END_ENTITY	TIC10/ONC201 synergizes with Bcl-2 / Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo .
26488112	8	Bcl-xL	1272,1278	Bcl-2	1266,1271	Bcl-xL	Bcl-2	598	596	Gene	Gene	antagonists|amod|START_ENTITY ABT-263|dep|antagonists combining|parataxis|ABT-263 combining|nmod|END_ENTITY	However , by combining SSA with the Bcl-2 / Bcl-xL antagonists ABT-263 or ABT-199 , we were able to overcome this pro-survival effect .
8603411	0	Bcl-xL	138,144	Bcl-2	129,134	Bcl-xL	Bcl-2	598	596	Gene	Gene	switched|nmod|START_ENTITY switched|nmod|END_ENTITY	Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL .
9881495	0	Bcl-xL	28,34	Bcl-2	70,75	Bcl-xL	Bcl-2	598	596	Gene	Gene	inhibiting|dobj|START_ENTITY Apoptosis|acl|inhibiting member|nsubj|Apoptosis member|nmod|family family|compound|END_ENTITY	Apoptosis inhibiting factor Bcl-xL might be the crucial member of the Bcl-2 gene family in colorectal_cancer .
17659302	0	Bcl-xL	88,94	Beclin-1	129,137	Bcl-xL	Beclin-1	598	8678	Gene	Gene	structure|nmod|START_ENTITY revealed|nmod|structure revealed|nmod|domain domain|nmod|END_ENTITY	Molecular basis of Bcl-xL 's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1 .
20731656	0	Bcl-xL	43,49	Brain-derived_neurotrophic_factor	0,33	Bcl-xL	Brain-derived neurotrophic factor	24888(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor enhances Bcl-xL expression through protein kinase casein kinase 2-activated and nuclear_factor_kappa_B-mediated pathway in rat hippocampus .
19596183	0	Bcl-xL	0,6	CD4	64,67	Bcl-xL	CD4	12048(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|cells cells|compound|END_ENTITY	Bcl-xL is required for the development of functional regulatory CD4 cells in lupus-afflicted mice following treatment with a tolerogenic peptide .
22197644	0	Bcl-xL	27,33	Clusterin	0,9	Bcl-xL	Clusterin	598	1191	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Clusterin interaction with Bcl-xL is associated with seizure-induced neuronal_death .
15770735	0	Bcl-xL	28,34	Connexin_26	0,11	Bcl-xL	Connexin 26	598	2706	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|END_ENTITY	Connexin_26 correlates with Bcl-xL and Bax proteins expression in colorectal_cancer .
14502606	0	Bcl-xL	32,38	Epidermal_growth_factor	0,23	Bcl-xL	Epidermal growth factor	598	1950	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces Bcl-xL gene expression and reduces apoptosis in porcine parthenotes developing in vitro .
19179380	0	Bcl-xL	48,54	Ets-2	14,19	Bcl-xL	Ets-2	598	2114	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral_sclerosis .
11179063	0	Bcl-xL	31,37	IGF-I	0,5	Bcl-xL	IGF-I	24888(Tax:10116)	24482(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IGF-I differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart .
18636161	0	Bcl-xL	34,40	JNK	108,111	Bcl-xL	JNK	598	5599	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
18758060	0	Bcl-xL	113,119	JNK	157,160	Bcl-xL	JNK	598	5599	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|cells cells|appos|END_ENTITY	Differential regulation of the antiapoptotic action of B-cell_lymphoma_2 -LRB- Bcl-2 -RRB- and B-cell_lymphoma extra long -LRB- Bcl-xL -RRB- by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 1-involved pathway in neuroglioma cells .
11567634	0	Bcl-xL	14,20	OX40	0,4	Bcl-xL	OX40	598	7293	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells .
26943323	0	Bcl-xL	72,78	PACS-2	0,6	Bcl-xL	PACS-2	12048(Tax:10090)	217893(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	PACS-2 mediates the ATM and NF-kB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage .
10435632	0	Bcl-xL	29,35	STAT5	55,60	Bcl-xL	STAT5	12048(Tax:10090)	20850(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line .
11756417	0	Bcl-xL	25,31	Stat5	56,61	Bcl-xL	Stat5	598	6776	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways .
14715264	0	Bcl-xL	95,101	TRAIL	33,38	Bcl-xL	TRAIL	598	8743	Gene	Gene	down-regulation|amod|START_ENTITY role|nmod|down-regulation Sensitization|dep|role Sensitization|acl|END_ENTITY	Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone_deacetylase : role of Bcl-xL down-regulation .
21683075	0	Bcl-xL	98,104	TRAIL	51,56	Bcl-xL	TRAIL	598	8743	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Oxaliplatin sensitizes human colon_cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL .
21699898	0	Bcl-xL	74,80	TRAIL	32,37	Bcl-xL	TRAIL	598	8743	Gene	Gene	inactivation|amod|START_ENTITY restore|nmod|inactivation restore|dobj|sensitivity sensitivity|compound|END_ENTITY	Oxaliplatin uses JNK to restore TRAIL sensitivity in cancer cells through Bcl-xL inactivation .
22898820	0	Bcl-xL	233,239	TRAIL	127,132	Bcl-xL	TRAIL	598	8743	Gene	Gene	regulating|dobj|START_ENTITY confers|advcl|regulating confers|dobj|resistance resistance|nmod|cells cells|nmod|END_ENTITY	The transcription_factor_Wilms_tumor 1 confers resistance in myeloid_leukemia cells against the proapoptotic therapeutic agent TRAIL -LRB- tumor_necrosis_factor_a-related_apoptosis-inducing_ligand -RRB- by regulating the antiapoptotic protein Bcl-xL .
26506422	0	Bcl-xL	0,6	TRAIL	91,96	Bcl-xL	TRAIL	598	8743	Gene	Gene	inhibition|amod|START_ENTITY sensitizes|nsubj|inhibition sensitizes|nmod|END_ENTITY	Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic_cancer cells to TRAIL .
26721202	0	Bcl-xL	167,173	TRAIL	45,50	Bcl-xL	TRAIL	598	8743	Gene	Gene	suppression|nmod|START_ENTITY cells|nmod|suppression death|nmod|cells induces|dobj|death induces|nsubj|Downregulation Downregulation|nmod|Nrf2 Nrf2|nmod|combination combination|nmod|END_ENTITY	Downregulation of Nrf2 by the combination of TRAIL and Valproic_acid induces apoptotic cell death of TRAIL-resistant papillary_thyroid_cancer cells via suppression of Bcl-xL .
11756417	0	Bcl-xL	25,31	Thrombopoietin	0,14	Bcl-xL	Thrombopoietin	598	7066	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways .
10467396	0	Bcl-xL	82,88	bcl-2	76,81	Bcl-xL	bcl-2	598	596	Gene	Gene	START_ENTITY|nsubj|Bcl-2 Bcl-2|dep|interacts interacts|nmod|END_ENTITY	Bcl-2 / E1B 19 kDa-interacting protein 3-like protein -LRB- Bnip3L -RRB- interacts with bcl-2 / Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability .
12426000	0	Bcl-xL	78,84	c-Rel	39,44	Bcl-xL	c-Rel	598	5966	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL , Mcl-1 , and Bcl-2 .
22403404	0	Bcl-xL	32,38	cIAP1/2	99,106	Bcl-xL	cIAP1/2	598	329;330	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 -LRB- cIAP1/2 -RRB- in resistance to HIV-Vpr-induced apoptosis .
10446348	0	Bcl-xL	0,6	caspase-3	34,43	Bcl-xL	caspase-3	12048(Tax:10090)	12367(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activation activation|amod|END_ENTITY	Bcl-xL is a negative regulator of caspase-3 activation in immature neurons during development .
18075502	0	Bcl-xL	34,40	clusterin	55,64	Bcl-xL	clusterin	12048(Tax:10090)	12759(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis .
10913120	0	Bcl-xL	0,6	cytochrome_c	16,28	Bcl-xL	cytochrome c	598	54205	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Bcl-xL inhibits cytochrome_c release but not mitochondrial depolarization during the activation of multiple death pathways by tumor_necrosis_factor-alpha .
18698039	0	Bcl-xL	59,65	inositol_trisphosphate_receptor_type_3	80,118	Bcl-xL	inositol trisphosphate receptor type 3	598	3710	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Gefitinib induction of in vivo detectable signals by Bcl-2 / Bcl-xL modulation of inositol_trisphosphate_receptor_type_3 .
17158961	0	Bcl-xl	0,6	Bax	29,32	Bcl-xl	Bax	598	581	Gene	Gene	have|nsubj|START_ENTITY have|xcomp|bind bind|dobj|END_ENTITY	Bcl-xl does not have to bind Bax to protect T cells from death .
19066994	0	Bcl-xl	43,49	Bcl-2	37,42	Bcl-xl	Bcl-2	598	596	Gene	Gene	inhibitors|amod|START_ENTITY screening|dep|inhibitors screening|nmod|END_ENTITY	In-silico screening of new potential Bcl-2 / Bcl-xl inhibitors as apoptosis modulators .
15048072	0	Bcl-xl	131,137	NF-kappa_B	102,112	Bcl-xl	NF-kappa B	598	4790	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Nitric_oxide sensitizes prostate_carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa_B and inhibition of Bcl-xl expression .
24839547	0	Bcl-xl	15,21	RelB	0,4	Bcl-xl	RelB	12048(Tax:10090)	19698(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RelB regulates Bcl-xl expression and the irradiation-induced apoptosis of murine prostate_cancer cells .
22917031	0	Bcl-xl	25,31	let-7c	9,15	Bcl-xl	let-7c	598	406885	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis .
25358426	0	Bcl1	0,4	Glucocorticoid_Receptor	25,48	Bcl1	Glucocorticoid Receptor	595	2908	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|nmod|Gene Gene|compound|END_ENTITY	Bcl1 Polymorphism of the Glucocorticoid_Receptor Gene and Treatment Response to Milnacipran and Fluvoxamine in Japanese Patients with Depression .
21093928	0	Bcl1	59,63	glucocorticoid_receptor	21,44	Bcl1	glucocorticoid receptor	595	2908	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Contributions of the glucocorticoid_receptor polymorphism -LRB- Bcl1 -RRB- and childhood abuse to risk of bulimia_nervosa .
18086859	0	Bcl10	76,81	CARMA1	47,53	Bcl10	CARMA1	8915	84433	Gene	Gene	formation|compound|START_ENTITY contributes|nmod|formation contributes|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
18086859	0	Bcl10	76,81	CARMA1	69,75	Bcl10	CARMA1	8915	84433	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
21041303	0	Bcl10	104,109	CARMA3	96,102	Bcl10	CARMA3	8915	29775	Gene	Gene	signalosome|compound|START_ENTITY signalosome|compound|END_ENTITY	Thrombin-dependent NF - -LCB- kappa -RCB- B activation and monocyte/endothelial adhesion are mediated by the CARMA3 Bcl10 MALT1 signalosome .
21513986	0	Bcl10	15,20	CaMKII	0,6	Bcl10	CaMKII	8915	818	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	CaMKII targets Bcl10 in T-cell receptor induced activation of NF-kB .
11356195	0	Bcl10	45,50	Carma1	0,6	Bcl10	Carma1	8915	84433	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Carma1 , a CARD-containing binding partner of Bcl10 , induces Bcl10 phosphorylation and NF-kappaB activation .
11356195	0	Bcl10	60,65	Carma1	0,6	Bcl10	Carma1	8915	84433	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Carma1 , a CARD-containing binding partner of Bcl10 , induces Bcl10 phosphorylation and NF-kappaB activation .
18086859	0	Bcl10	76,81	MALT1	82,87	Bcl10	MALT1	8915	10892	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
21041303	0	Bcl10	104,109	MALT1	111,116	Bcl10	MALT1	8915	10892	Gene	Gene	signalosome|compound|START_ENTITY signalosome|compound|END_ENTITY	Thrombin-dependent NF - -LCB- kappa -RCB- B activation and monocyte/endothelial adhesion are mediated by the CARMA3 Bcl10 MALT1 signalosome .
18287044	0	Bcl10	34,39	NEMO	0,4	Bcl10	NEMO	8915	8517	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation .
17540779	0	Bcl10	0,5	NF-kappaB	41,50	Bcl10	NF-kappaB	8915	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells .
17540779	0	Bcl10	0,5	NF-kappaB	41,50	Bcl10	NF-kappaB	8915	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells .
17371994	0	Bcl10	0,5	TCR	15,18	Bcl10	TCR	8915	6962	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Bcl10 controls TCR - and FcgammaR-induced actin polymerization .
12589800	0	Bcl10	55,60	p38	17,20	Bcl10	p38	8915	1432	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	UV-light induces p38 MAPK-dependent phosphorylation of Bcl10 .
23361909	0	Bcl11a	54,60	Klf1	48,52	Bcl11a	Klf1	14025(Tax:10090)	16596(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|dobj|mice	Erythropoiesis and globin switching in compound Klf1 : : Bcl11a mutant mice .
20621101	0	Bcl2	16,20	BAX	47,50	Bcl2	BAX	596	581	Gene	Gene	Upregulation|nmod|START_ENTITY inhibits|nsubj|Upregulation inhibits|dobj|insertion insertion|compound|END_ENTITY	Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria .
23994239	0	Bcl2	99,103	Bax	94,97	Bcl2	Bax	596	581	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Significant modulation of macrophages associated cytokines TNF-a , VEGF and apoptotoic protein Bax , Bcl2 abrogates_tumor cells .
26074734	0	Bcl2	44,48	Bax	17,20	Bcl2	Bax	596	581	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|regulation regulation|nmod|END_ENTITY	Up regulation of Bax and down regulation of Bcl2 during 3-NC mediated apoptosis in human cancer cells .
19228691	0	Bcl2	29,33	Cyclophilin_D	0,13	Bcl2	Cyclophilin D	596	5481	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cyclophilin_D interacts with Bcl2 and exerts an anti-apoptotic effect .
19258038	0	Bcl2	0,4	MMP-2	29,34	Bcl2	MMP-2	596	4313	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Bcl2 enhances c-Myc-mediated MMP-2 expression of vascular smooth muscle cells .
23612742	0	Bcl2	62,66	MicroRNA-205	0,12	Bcl2	MicroRNA-205	596	406988	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	MicroRNA-205 , a novel regulator of the anti-apoptotic protein Bcl2 , is downregulated in prostate_cancer .
12086670	0	Bcl2	0,4	Mitf	51,55	Bcl2	Mitf	12043(Tax:10090)	17342(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability .
17487067	0	Bcl2	57,61	P53	47,50	Bcl2	P53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	PCNA|appos|START_ENTITY PCNA|compound|END_ENTITY	Differential protection and transactivation of P53 , P21 , Bcl2 , PCNA , cyclin_G , and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin .
26556865	0	Bcl2	44,48	PPARa	0,5	Bcl2	PPARa	596	5465	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	PPARa induces cell apoptosis by destructing Bcl2 .
23994239	0	Bcl2	99,103	VEGF	66,70	Bcl2	VEGF	596	7422	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Significant modulation of macrophages associated cytokines TNF-a , VEGF and apoptotoic protein Bax , Bcl2 abrogates_tumor cells .
9713280	0	Bcl2	0,4	VEGF	58,62	Bcl2	VEGF	596	7422	Gene	Gene	vascular_endothelial_growth_factor|compound|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Bcl2 and p53 regulate vascular_endothelial_growth_factor -LRB- VEGF -RRB- - mediated angiogenesis in non-small_cell_lung_carcinoma .
25225463	0	Bcl2	53,57	cyclin_D1	113,122	Bcl2	cyclin D1	596	595	Gene	Gene	epidermal|dep|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
25225463	0	Bcl2	53,57	cyclooxygenase-2	95,111	Bcl2	cyclooxygenase-2	596	5743	Gene	Gene	epidermal|dep|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
25225463	0	Bcl2	53,57	epidermal_growth_factor_receptor	14,46	Bcl2	epidermal growth factor receptor	596	1956	Gene	Gene	epidermal|dep|START_ENTITY epidermal|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
18437159	0	Bcl2	0,4	p38alpha	34,42	Bcl2	p38alpha	12043(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Bcl2 , a transcriptional target of p38alpha , is critical for neuronal commitment of mouse embryonic stem cells .
25225463	0	Bcl2	53,57	p53	48,51	Bcl2	p53	596	7157	Gene	Gene	epidermal|dep|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
25225463	0	Bcl2	53,57	vascular_endothelial_growth_factor	59,93	Bcl2	vascular endothelial growth factor	596	7422	Gene	Gene	epidermal|dep|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
11689480	0	Bcl2-L-10	0,9	Bcl-2	48,53	Bcl2-L-10	Bcl-2	10017	596	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Bcl2-L-10 , a novel anti-apoptotic member of the Bcl-2 family , blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway .
19632297	0	Bcl2-interacting_killer	27,50	BIK	52,55	Bcl2-interacting killer	BIK	638	638	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between the Bcl2-interacting_killer -LRB- BIK -RRB- gene and schizophrenia .
19439730	0	Bcl2-like_10	8,20	Bcl2l10	22,29	Bcl2-like 10	Bcl2l10	12049(Tax:10090)	12049(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Bcl2-like_10 -LRB- Bcl2l10 -RRB- in Regulating Mouse Oocyte Maturation .
18549468	0	Bcl2L11	71,78	Bim	80,83	Bcl2L11	Bim	10018	10018	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a candidate alternative promoter region of the human Bcl2L11 -LRB- Bim -RRB- gene .
22431925	0	Bcl2L12	88,95	Bcl-2	12,17	Bcl2L12	Bcl-2	83596	596	Gene	Gene	role|dep|START_ENTITY role|nmod|proteins proteins|compound|END_ENTITY	The role of Bcl-2 family proteins in therapy responses of malignant astrocytic_gliomas : Bcl2L12 and beyond .
19439730	0	Bcl2l10	22,29	Bcl2-like_10	8,20	Bcl2l10	Bcl2-like 10	12049(Tax:10090)	12049(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Bcl2-like_10 -LRB- Bcl2l10 -RRB- in Regulating Mouse Oocyte Maturation .
18815299	0	Bcl3	19,23	Tax	36,39	Bcl3	Tax	602	1491938(Tax:11908)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The proto-oncogene Bcl3 , induced by Tax , represses Tax-mediated transcription via p300 displacement from the human_T-cell_leukemia_virus_type_1 promoter .
20471052	0	Bcl3	108,112	Tax	94,97	Bcl3	Tax	602	1491938(Tax:11908)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the PI3K-Akt pathway by human_T_cell_leukemia_virus_type_1 _ -LRB- HTLV-1 -RRB- oncoprotein Tax increases Bcl3 expression , which is associated with enhanced growth of HTLV-1-infected T cells .
9812988	0	Bcl3	0,4	retinoid_X_receptor	70,89	Bcl3	retinoid X receptor	602	6256	Gene	Gene	START_ENTITY|nmod|coactivator coactivator|nmod|END_ENTITY	Bcl3 , an IkappaB protein , as a novel transcription coactivator of the retinoid_X_receptor .
17307796	0	Bcl6	0,4	CD4	57,60	Bcl6	CD4	12053(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nsubj|START_ENTITY cells|amod|essential essential|nmod|generation generation|nmod|T T|compound|END_ENTITY	Bcl6 is essential for the generation of long-term memory CD4 + T cells .
21131418	0	Bcl6	0,4	CD4	46,49	Bcl6	CD4	12053(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|+ +|compound|END_ENTITY	Bcl6 is required for the development of mouse CD4 + and CD8a + dendritic cells .
22427637	0	Bcl6	0,4	CD4	59,62	Bcl6	CD4	604	920	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|xcomp|instruct instruct|xcomp|differentiation differentiation|nsubj|T T|compound|END_ENTITY	Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation .
23487426	0	Bcl6	0,4	CD4	34,37	Bcl6	CD4	604	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory .
24489092	0	Bcl6	39,43	STAT1	30,35	Bcl6	STAT1	604	6772	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Type I IFN induces binding of STAT1 to Bcl6 : divergent roles of STAT family transcription factors in the T follicular helper cell genetic program .
23053511	0	Bcl6	0,4	Th2	18,21	Bcl6	Th2	12053(Tax:10090)	15111(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|activity activity|amod|END_ENTITY	Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function .
15604256	0	Bcr-Abl	66,73	Bcr-Abl	77,84	Bcr-Abl	Bcr-Abl	25	25	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Protein_kinase_D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl + human myeloid_leukemia cells .
15604256	0	Bcr-Abl	77,84	Bcr-Abl	66,73	Bcr-Abl	Bcr-Abl	25	25	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Protein_kinase_D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl + human myeloid_leukemia cells .
18246120	0	Bcr-Abl	0,7	IGF-1	26,31	Bcr-Abl	IGF-1	25	3479	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Bcr-Abl induces autocrine IGF-1 signaling .
12370803	0	Bcr-Abl	39,46	Jak2	0,4	Bcr-Abl	Jak2	25	3717	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Jak2 is involved in c-Myc induction by Bcr-Abl .
21183952	0	Bcr-Abl	25,32	Janus_kinase_2	0,14	Bcr-Abl	Janus kinase 2	25	3717	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Janus_kinase_2 regulates Bcr-Abl signaling in chronic_myeloid_leukemia .
11606405	0	Bcr-Abl	48,55	Mdm2	16,20	Bcr-Abl	Mdm2	25	4193	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Requirement for Mdm2 in the survival effects of Bcr-Abl and interleukin_3 in hematopoietic cells .
15604256	0	Bcr-Abl	66,73	Protein_kinase_D2	0,17	Bcr-Abl	Protein kinase D2	25	25865	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Protein_kinase_D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl + human myeloid_leukemia cells .
15604256	0	Bcr-Abl	77,84	Protein_kinase_D2	0,17	Bcr-Abl	Protein kinase D2	25	25865	Gene	Gene	cells|compound|START_ENTITY Bcr-Abl|nmod|cells mediates|nmod|Bcr-Abl mediates|nsubj|END_ENTITY	Protein_kinase_D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl + human myeloid_leukemia cells .
20028985	0	Bcr-Abl	56,63	Raf_kinase_inhibitor_protein	13,41	Bcr-Abl	Raf kinase inhibitor protein	25	5037	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Reduction of Raf_kinase_inhibitor_protein expression by Bcr-Abl contributes to chronic_myelogenous_leukemia proliferation .
17349636	0	Bcr-Abl	50,57	TGFbeta	20,27	Bcr-Abl	TGFbeta	25	7040	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Upregulation of the TGFbeta signalling pathway by Bcr-Abl : implications for haemopoietic cell growth and chronic_myeloid_leukaemia .
17318191	0	Bcr-Abl	0,7	beta-catenin	19,31	Bcr-Abl	beta-catenin	25	1499	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Bcr-Abl stabilizes beta-catenin in chronic_myeloid_leukemia through its tyrosine phosphorylation .
12370803	0	Bcr-Abl	39,46	c-Myc	20,25	Bcr-Abl	c-Myc	25	4609	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|induction induction|amod|END_ENTITY	Jak2 is involved in c-Myc induction by Bcr-Abl .
15857938	0	Bcr-Abl	0,7	osteopontin	18,29	Bcr-Abl	osteopontin	25	6696	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Bcr-Abl regulates osteopontin transcription via Ras , PI-3K , aPKC , Raf-1 , and MEK .
16078266	0	Bcr-Abl	50,57	p190	45,49	Bcr-Abl	p190	25	8506	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	AMN107 , a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute_lymphoblastic_leukemia cells .
10779439	0	Bcr-Abl	127,134	p210	122,126	Bcr-Abl	p210	25	14027(Tax:10090)	Gene	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases .
14506164	0	Bcr-Abl	15,22	p210	10,14	Bcr-Abl	p210	25	2125	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of p210 -LRB- Bcr-Abl -RRB- on ultraviolet C wavelength-induced DNA damage and repair .
9704934	0	Bcr-Abl	5,12	p210	0,4	Bcr-Abl	p210	25	2125	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic_myeloid_leukaemia .
14670960	0	Bcr-Abl	0,7	protein_kinase_Ciota	18,38	Bcr-Abl	protein kinase Ciota	25	5584	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Bcr-Abl regulates protein_kinase_Ciota -LRB- PKCiota -RRB- transcription via an Elk1 site in the PKCiota promoter .
25656651	0	Bcr-Abl	0,7	tyrosine_kinase	8,23	Bcr-Abl	tyrosine kinase	25	7294	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Bcr-Abl tyrosine_kinase inhibitors : a patent review .
16409301	0	Bcr-abl	5,12	P210	0,4	BCR-ABL	P210	25	2125	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	P210 Bcr-abl tyrosine kinase interaction with histone_deacetylase_1 modifies histone H4 acetylation and chromatin structure of chronic_myeloid_leukaemia haematopoietic progenitors .
16409301	0	Bcr-abl	5,12	histone_deacetylase_1	46,67	BCR-ABL	histone deacetylase 1	25	3065	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	P210 Bcr-abl tyrosine kinase interaction with histone_deacetylase_1 modifies histone H4 acetylation and chromatin structure of chronic_myeloid_leukaemia haematopoietic progenitors .
15982636	0	Bcr/Abl	15,22	Crkl	107,111	Bcr/Abl	Crkl	25	1399	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Bcr/Abl with C3G , an exchange factor for the small GTPase Rap1 , through the adapter protein Crkl .
22865631	0	Bcr/Abl	110,117	MMP-9	65,70	Bcr/Abl	MMP-9	25;613	4318	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Gallic_acid downregulates matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and MMP-9 in human leukemia cells with expressed Bcr/Abl .
15982636	0	Bcr/Abl	15,22	Rap1	73,77	Bcr/Abl	Rap1	25	5906	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|factor factor|nmod|END_ENTITY	Interaction of Bcr/Abl with C3G , an exchange factor for the small GTPase Rap1 , through the adapter protein Crkl .
18813851	0	Bcr/Abl	0,7	Rap1	86,90	Bcr/Abl	Rap1	25	5906	Gene	Gene	P190|compound|START_ENTITY interaction|nsubj|P190 interaction|nmod|Spa-1 Spa-1|appos|protein protein|nmod|END_ENTITY	Bcr/Abl P190 interaction with Spa-1 , a GTPase activating protein for the small GTPase Rap1 .
12879454	0	Bcr/Abl	80,87	Stat5	20,25	Bcr/Abl	Stat5	25	6776	Gene	Gene	activity|compound|START_ENTITY measure|nmod|activity phosphorylated|nmod|measure phosphorylated|nsubj|Immunoreactivity Immunoreactivity|nmod|END_ENTITY	Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity .
16959944	0	Bcrp	22,26	Abcg2	28,33	Bcrp	Abcg2	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The important role of Bcrp -LRB- Abcg2 -RRB- in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen , 4-methylumbelliferone , and harmol in mice .
22581381	0	Bcrp	50,54	breast_cancer_resistance_protein	16,48	Bcrp	breast cancer resistance protein	9429	9429	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of breast_cancer_resistance_protein -LRB- Bcrp -RRB- in endocrine organs and inhibition of its transport activity by steroid hormones .
19996279	0	Bcrp1	39,44	Mrp2	7,11	Bcrp1	Mrp2	26357(Tax:10090)	12780(Tax:10090)	Gene	Gene	Abcc2|appos|START_ENTITY Abcc2|appos|END_ENTITY	Abcc2 -LRB- Mrp2 -RRB- , Abcc3 -LRB- Mrp3 -RRB- , and Abcg2 -LRB- Bcrp1 -RRB- are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo .
21602547	0	Bcrp1	73,78	breast_cancer_resistance_protein	39,71	Bcrp1	breast cancer resistance protein	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Glucocorticoid regulation of placental breast_cancer_resistance_protein -LRB- Bcrp1 -RRB- in the mouse .
22575765	0	Bcs1	0,4	AAA	8,11	Bcs1	AAA	617	100329167	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Bcs1 , a AAA protein of the mitochondria with a role in the biogenesis of the respiratory chain .
11134339	0	Bcy1	84,88	Zds1	98,102	Bcy1	Zds1	854778(Tax:4932)	855316(Tax:4932)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain .
19217433	0	Bdnf	0,4	MECP2	96,101	Bdnf	MECP2	627	4204	Gene	Gene	overexpression|compound|START_ENTITY prevents|nsubj|overexpression prevents|dep|caused caused|nmod|mutations mutations|compound|END_ENTITY	Bdnf overexpression in hippocampal neurons prevents dendritic_atrophy caused by Rett-associated MECP2 mutations .
17046689	0	Bdnf	69,73	MeCP2	34,39	Bdnf	MeCP2	627	4204	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription , dendritic growth , and spine maturation .
12242406	0	Bean	95,99	ATPase	65,71	Bean	ATPase	146227	1769	Gene	Gene	Cells|nmod|START_ENTITY END_ENTITY|nmod|Cells	Cytosolic Concentration of Ca2 + Regulates the Plasma Membrane H + - ATPase in Guard Cells of Fava Bean .
19318089	0	Beclin-1	16,24	Bcl-2	59,64	Beclin-1	Bcl-2	8678	596	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death .
19347031	0	Beclin-1	21,29	Bcl-2	0,5	Beclin-1	Bcl-2	8678	596	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function .
23436561	0	Beclin-1	95,103	Bcl-2	63,68	Beclin-1	Bcl-2	100762045	100774873	Gene	Gene	inhibition|appos|START_ENTITY END_ENTITY|nmod|inhibition	Anti-cell death engineering of CHO cells : co-overexpression of Bcl-2 for apoptosis inhibition , Beclin-1 for autophagy induction .
25032846	0	Beclin-1	80,88	Bcl-2	94,99	Beclin-1	Bcl-2	8678	596	Gene	Gene	releasing|dobj|START_ENTITY releasing|nmod|END_ENTITY	CHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2 .
17659302	0	Beclin-1	129,137	Bcl-xL	88,94	Beclin-1	Bcl-xL	8678	598	Gene	Gene	domain|nmod|START_ENTITY revealed|nmod|domain revealed|nmod|structure structure|nmod|END_ENTITY	Molecular basis of Bcl-xL 's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1 .
23817237	0	Beclin-1	13,21	ULK1	0,4	Beclin-1	ULK1	8678	8408	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	ULK1 targets Beclin-1 in autophagy .
25896938	0	Beclin-1	14,22	mTOR	37,41	Beclin-1	mTOR	8678	21977(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation on Beclin-1 expression by mTOR in CoCl2-induced HT22 cell ischemia-reperfusion injury .
20057503	0	Beclin1	54,61	PINK1	33,38	Beclin1	PINK1	8678	65018	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy .
19395874	0	Beclin_1	19,27	Bcl-2	96,101	Beclin 1	Bcl-2	8678	596	Gene	Gene	Phosphorylation|nmod|START_ENTITY promotes|nsubj|Phosphorylation promotes|advcl|weakening weakening|nmod|END_ENTITY	Phosphorylation of Beclin_1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL .
19535901	0	Beclin_1	12,20	Bcl-2	82,87	Beclin 1	Bcl-2	8678	596	Gene	Gene	suppress|nsubj|START_ENTITY suppress|dobj|function function|nmod|END_ENTITY	Why does n't Beclin_1 , a BH3-only_protein , suppress the anti-apoptotic function of Bcl-2 ?
20090905	0	Beclin_1	27,35	Bcl-2	84,89	Beclin 1	Bcl-2	8678	596	Gene	Gene	dependence|nmod|START_ENTITY dependence|nmod|END_ENTITY	Differential dependence on Beclin_1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal_cancer cells .
22485198	0	Beclin_1	6,14	Bcl-2	0,5	Beclin 1	Bcl-2	8678	596	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	Bcl-2 : Beclin_1 complex : multiple , mechanisms regulating autophagy/apoptosis toggle switch .
22579788	0	Beclin_1	79,87	Bcl-2	73,78	Beclin 1	Bcl-2	8678	596	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2 / Beclin_1 interaction in human glioma U251 cells .
24326530	0	Beclin_1	77,85	Bcl-2	71,76	Beclin 1	Bcl-2	8678	596	Gene	Gene	complex-dependent|amod|START_ENTITY death|parataxis|complex-dependent death|nmod|END_ENTITY	1-Methyl-4-phenylpyridinium-induced cell death via autophagy through a Bcl-2 / Beclin_1 complex-dependent pathway .
25565814	0	Beclin_1	100,108	Bcl-2	109,114	Beclin 1	Bcl-2	8678	596	Gene	Gene	complex|amod|START_ENTITY complex|dep|END_ENTITY	Ferroferric_oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin_1 / Bcl-2 / VPS34 complex .
25631043	0	Beclin_1	135,143	Bcl-2	171,176	Beclin 1	Bcl-2	8678	596	Gene	Gene	Leucine-rich_Pentatricopeptide_Repeat-containing_Protein|nmod|START_ENTITY Leucine-rich_Pentatricopeptide_Repeat-containing_Protein|dep|END_ENTITY	The Viral Restriction Factor Tetherin Prevents Leucine-rich_Pentatricopeptide_Repeat-containing_Protein -LRB- LRPPRC -RRB- from Association with Beclin_1 and B-cell_CLL / lymphoma_2 -LRB- Bcl-2 -RRB- and Enhances Autophagy and Mitophagy .
17891140	0	Beclin_1	21,29	Bif-1	0,5	Beclin 1	Bif-1	8678	51100	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Bif-1 interacts with Beclin_1 through UVRAG and regulates autophagy and tumorigenesis .
16522639	0	Beclin_1	65,73	Huntingtin	51,61	Beclin 1	Huntingtin	8678	3064	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of intracellular accumulation of mutant Huntingtin by Beclin_1 .
24760274	0	Beclin_1	15,23	Stat3	0,5	Beclin 1	Stat3	8678	6774	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Stat3 inhibits Beclin_1 expression through recruitment of HDAC3 in nonsmall cell lung_cancer cells .
22205736	0	Beclin_1	83,91	TRS1	34,38	Beclin 1	TRS1	8678	3077523(Tax:10359)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The human_cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin_1 .
25565814	0	Beclin_1	100,108	VPS34	115,120	Beclin 1	VPS34	8678	5289	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Ferroferric_oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin_1 / Bcl-2 / VPS34 complex .
8300560	1	Bem3	141,145	Cdc24	97,102	Bem3	Cdc24	855988(Tax:4932)	851190(Tax:4932)	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Catalysis of guanine_nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3 .
7910161	0	Bet	73,76	HLA-DRB3	20,28	Bet	HLA-DRB3	92737	3125	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association between HLA-DRB3 * 0101 and immunoglobulin-E responsiveness to Bet v I .
9243499	0	Bet1p	0,5	Bos1p	28,33	Bet1p	Bos1p	854813(Tax:4932)	850767(Tax:4932)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Bet1p activates the v-SNARE Bos1p .
25581738	0	Bet3	0,4	Ypt1	46,50	Bet3	Ypt1	853942(Tax:4932)	850505(Tax:4932)	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	Bet3 participates in autophagy through GTPase Ypt1 in Saccharomyces_cerevisiae .
18308774	0	Beta-2-microglobulin	0,20	N-acetyl-beta-glucosaminidase	36,65	Beta-2-microglobulin	N-acetyl-beta-glucosaminidase	567	10724	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	Beta-2-microglobulin is superior to N-acetyl-beta-glucosaminidase in predicting prognosis in idiopathic_membranous_nephropathy .
20353789	0	Beta-2_adrenergic_receptor	0,26	MAGI-3	84,90	Beta-2 adrenergic receptor	MAGI-3	154	260425	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|regulated regulated|nmod|END_ENTITY	Beta-2_adrenergic_receptor mediated ERK activation is regulated by interaction with MAGI-3 .
11426895	0	Beta-3	0,6	beta-2	14,20	Beta-3	beta-2	1934	10242	Gene	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Beta-3 versus beta-2 adrenergic agonists and preterm_labour : in vitro uterine relaxation effects .
9200670	0	Beta-3_adrenoceptor	0,19	beta-3AR	21,29	Beta-3 adrenoceptor	beta-3AR	11556(Tax:10090)	11556(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Beta-3_adrenoceptor -LRB- beta-3AR -RRB- expression in leptin treated OB/OB mice .
27045591	0	Beta-Catenin	10,22	GSK3beta	36,44	Beta-Catenin	GSK3beta	84353(Tax:10116)	84027(Tax:10116)	Gene	Gene	Activity|amod|START_ENTITY Activity|nmod|Cells Cells|compound|END_ENTITY	Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction .
17040897	0	Beta-Catenin	0,12	cyclooxygenase-2	24,40	Beta-Catenin	cyclooxygenase-2	1499	5743	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|amod|END_ENTITY	Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3 ' - UTR .
19946124	0	Beta-actin	0,10	endothelial_nitric-oxide_synthase	28,61	Beta-actin	endothelial nitric-oxide synthase	728378	4846	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Beta-actin association with endothelial_nitric-oxide_synthase modulates nitric_oxide and superoxide generation from the enzyme .
14534298	0	Beta-arrestin1	0,14	insulin-like_growth_factor_1	24,52	Beta-arrestin1	insulin-like growth factor 1	109689(Tax:10090)	16000(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Beta-arrestin1 mediates insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- activation of phosphatidylinositol 3-kinase -LRB- PI3K -RRB- and anti-apoptosis .
12488444	0	Beta-arrestin_2	0,15	Mdm2	93,97	Beta-arrestin 2	Mdm2	409	4193	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Beta-arrestin_2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2 .
20228252	0	Beta-arrestin_2	0,15	inducible_nitric_oxide_synthase	87,118	Beta-arrestin 2	inducible nitric oxide synthase	409	4843	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Beta-arrestin_2 is required for B1_receptor-dependent post-translational activation of inducible_nitric_oxide_synthase .
11956815	0	Beta-catenin	0,12	APC	44,47	Beta-catenin	APC	1499	324	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis .
18854359	0	Beta-catenin	0,12	APC	55,58	Beta-catenin	APC	1499	324	Gene	Gene	degradation|amod|START_ENTITY degradation|acl|mediated mediated|nmod|domain domain|nmod|END_ENTITY	Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal , desmoid_and_duodenal_tumours .
18854359	0	Beta-catenin	0,12	APC	97,100	Beta-catenin	APC	1499	324	Gene	Gene	degradation|amod|START_ENTITY provides|nsubj|degradation provides|dobj|model model|nmod|selection selection|nmod|mutations mutations|compound|END_ENTITY	Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal , desmoid_and_duodenal_tumours .
19864427	0	Beta-catenin	0,12	Atoh1	26,31	Beta-catenin	Atoh1	12387(Tax:10090)	11921(Tax:10090)	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Beta-catenin up-regulates Atoh1 expression in neural progenitor cells by interaction with an Atoh1 3 ' enhancer .
19696224	0	Beta-catenin	0,12	Bax	71,74	Beta-catenin	Bax	1499	581	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax .
23396188	0	Beta-catenin	0,12	Bmp	30,33	Beta-catenin	Bmp	1499	649	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Beta-catenin -LRB- CTNNB1 -RRB- induces Bmp expression in urogenital_sinus epithelium and participates in prostatic bud initiation and patterning .
12394763	0	Beta-catenin	0,12	C-myc	57,62	Beta-catenin	C-myc	1499	4609	Gene	Gene	mutations|amod|START_ENTITY correlate|nsubj|mutations correlate|nmod|expression expression|nmod|END_ENTITY	Beta-catenin mutations correlate with over expression of C-myc and cyclin_D1 Genes in bladder_cancer .
14517842	0	Beta-catenin	0,12	E-cadherin	99,109	Beta-catenin	E-cadherin	1499	999	Gene	Gene	accumulation|amod|START_ENTITY correlates|nsubj|accumulation correlates|nmod|loss loss|nmod|END_ENTITY	Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53 , but not with expression of conventional WNT-1 target genes .
17090604	0	Beta-catenin	0,12	LEF-1	52,57	Beta-catenin	LEF-1	1499	51176	Gene	Gene	relieves|nsubj|START_ENTITY relieves|dobj|suppression suppression|nmod|END_ENTITY	Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells .
19553286	0	Beta-catenin	0,12	Mitf	109,113	Beta-catenin	Mitf	12387(Tax:10090)	17342(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|END_ENTITY	Beta-catenin controls differentiation of the retinal_pigment_epithelium in the mouse optic cup by regulating Mitf and Otx2 expression .
18316399	0	Beta-catenin	0,12	MyoD	28,32	Beta-catenin	MyoD	1499	4654	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Beta-catenin interacts with MyoD and regulates its transcription activity .
17196549	0	Beta-catenin	0,12	Nanog	26,31	Beta-catenin	Nanog	12387(Tax:10090)	71950(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Beta-catenin up-regulates Nanog expression through interaction with Oct-3 / 4 in embryonic stem cells .
22053859	4	Beta-catenin	642,654	SLN	680,683	beta-catenin	SLN	1499	6588	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Beta-catenin expression in metastatic SLN -LRB- s -RRB- and liver metastatic lesions was examined by immunohistochemistry .
26459757	0	Beta-catenin	0,12	T-cell_factor	123,136	Beta-catenin	T-cell factor	1499	3172	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|nmod|sites sites|amod|END_ENTITY	Beta-catenin up-regulates the constitutive and virus-induced transcriptional capacity of the interferon-b promoter through T-cell_factor binding sites .
10987273	0	Beta-catenin	0,12	androgen_receptor	21,38	Beta-catenin	androgen receptor	1499	367	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|activity activity|compound|END_ENTITY	Beta-catenin affects androgen_receptor transcriptional activity and ligand specificity .
12588987	0	Beta-catenin	0,12	androgen_receptor	62,79	Beta-catenin	androgen receptor	1499	367	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|region region|nmod|END_ENTITY	Beta-catenin binds to the activation_function_2 region of the androgen_receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription .
15514031	0	Beta-catenin	0,12	androgen_receptor	89,106	Beta-catenin	androgen receptor	1499	367	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|transactivation transactivation|nmod|END_ENTITY	Beta-catenin is involved in insulin-like_growth_factor_1-mediated transactivation of the androgen_receptor .
15810077	0	Beta-catenin	0,12	c-myc	54,59	Beta-catenin	c-myc	1499	4609	Gene	Gene	up-regulates|amod|START_ENTITY up-regulates|dep|expression expression|nmod|cyclinD1 cyclinD1|amod|END_ENTITY	Beta-catenin up-regulates the expression of cyclinD1 , c-myc and MMP-7 in human pancreatic_cancer : relationships with carcinogenesis and metastasis .
10201372	0	Beta-catenin	0,12	cyclin_D1	37,46	Beta-catenin	cyclin D1	1499	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Beta-catenin regulates expression of cyclin_D1 in colon_carcinoma cells .
10759547	0	Beta-catenin	0,12	cyclin_D1	72,81	Beta-catenin	cyclin D1	1499	595	Gene	Gene	START_ENTITY|dep|roles roles|nmod|expression expression|amod|END_ENTITY	Beta-catenin , a novel prognostic marker for breast_cancer : its roles in cyclin_D1 expression and cancer progression .
15111320	0	Beta-catenin	0,12	cyclin_D1	96,105	Beta-catenin	cyclin D1	1499	595	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|pathway pathway|nmod|END_ENTITY	Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin_D1 during squamous differentiation of endometrial_carcinoma cells .
16740029	0	Beta-catenin	0,12	cyclin_D1	48,57	Beta-catenin	cyclin D1	1499	595	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|expression expression|amod|END_ENTITY	Beta-catenin nuclear expression correlates with cyclin_D1 expression in primary and metastatic synovial_sarcoma : a tissue microarray study .
12147254	0	Beta-catenin	0,12	cyclooxygenase-2	37,53	Beta-catenin	cyclooxygenase-2	1499	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|chondrocytes chondrocytes|amod|END_ENTITY	Beta-catenin regulates expression of cyclooxygenase-2 in articular chondrocytes .
15936755	0	Beta-catenin	0,12	lef-1	118,123	Beta-catenin	lef-1	1499	51176	Gene	Gene	act|nsubj|START_ENTITY act|nmod|receptor receptor|amod|lymphocyte_enhancer_factor-1 lymphocyte_enhancer_factor-1|dep|END_ENTITY	Beta-catenin can act as a nuclear import receptor for its partner transcription factor , lymphocyte_enhancer_factor-1 -LRB- lef-1 -RRB- .
12438242	0	Beta-catenin	0,12	low-molecular-weight_protein_tyrosine_phosphatase	28,77	Beta-catenin	low-molecular-weight protein tyrosine phosphatase	1499	52	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Beta-catenin interacts with low-molecular-weight_protein_tyrosine_phosphatase leading to cadherin-mediated cell-cell adhesion increase .
14973118	0	Beta-catenin	0,12	urokinase_plasminogen_activator	48,79	Beta-catenin	urokinase plasminogen activator	1499	5328	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Beta-catenin up-regulates the expression of the urokinase_plasminogen_activator in human colorectal_tumors .
6309526	0	Beta-endorphin	0,14	beta-lipotropin	16,31	Beta-endorphin	beta-lipotropin	5443	5443	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Beta-endorphin , beta-lipotropin and adrenocorticotropic hormone levels in cerebrospinal fluid , and brain_damage in chronic alcoholics .
6319955	0	Beta-endorphin	0,14	insulin	43,50	Beta-endorphin	insulin	5443	3630	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Beta-endorphin stimulates the secretion of insulin and glucagon_in_diabetes_mellitus .
1477186	0	Beta-endorphin	0,14	interleukin-2	24,37	Beta-endorphin	interleukin-2	18976(Tax:10090)	16183(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes .
2833533	0	Beta-endorphin	0,14	interleukin-2	24,37	Beta-endorphin	interleukin-2	18976(Tax:10090)	16183(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Beta-endorphin enhances interleukin-2 -LRB- IL-2 -RRB- production in murine lymphocytes .
2535139	0	Beta-endorphin	0,14	interleukin_1	25,38	Beta-endorphin	interleukin 1	18976(Tax:10090)	111343(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Beta-endorphin regulates interleukin_1 production and release by murine bone marrow macrophages .
23762954	0	Beta-lactamase	15,29	BLA	31,34	Beta-lactamase	BLA	4290808(Tax:287)	4290808(Tax:287)	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|END_ENTITY	ML302 , a Novel Beta-lactamase -LRB- BLA -RRB- Inhibitor VIM-2 and IMP-1 are Ambler class B metallo-b-lactamases -LRB- MBL -RRB- capable of hydrolyzing a broad-spectrum of b-lactam antibiotics .
17112725	0	Beta-secretase	0,14	BACE-1	16,22	Beta-secretase	BACE-1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Beta-secretase -LRB- BACE-1 -RRB- inhibitors : accounting for 10s loop flexibility using rigid active sites .
11978599	0	Beta-trace_protein	0,18	cystatin_C	20,30	Beta-trace protein	cystatin C	5730	1471	Gene	Gene	beta|amod|START_ENTITY beta|dep|END_ENTITY	Beta-trace_protein , cystatin_C , beta -LRB- 2 -RRB- - microglobulin , and creatinine compared for detecting impaired glomerular filtration rates in children .
8892616	0	Beta1	0,5	Fyn	85,88	Beta1	Fyn	3779	2534	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Beta1 integrin-mediated activation of focal adhesion kinase and its association with Fyn and Zap-70 in human NK cells .
11265644	0	Beta1	0,5	beta2	56,61	Beta1	beta2	3779	10242	Gene	Gene	activation|amod|START_ENTITY promotes|nsubj|activation promotes|dobj|adhesion adhesion|amod|END_ENTITY	Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin .
10356979	0	Beta2	0,5	Pyk2	68,72	Beta2	Pyk2	10242	2185	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Beta2 integrin-dependent phosphorylation of protein-tyrosine kinase Pyk2 stimulated by tumor_necrosis_factor_alpha and fMLP in human neutrophils adherent to fibrinogen .
15929983	0	Beta2	0,5	nicotinic_acetylcholine_receptor	65,97	Beta2	nicotinic acetylcholine receptor	10242	1137	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic_acetylcholine_receptor .
23056266	0	Beta2-adaptin	0,13	actopaxin	20,29	Beta2-adaptin	actopaxin	163	55742	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Beta2-adaptin binds actopaxin and regulates cell spreading , migration and matrix degradation .
23436577	0	Beta2-adrenergic_receptor	0,25	CD4	39,42	Beta2-adrenergic receptor	CD4	154	920	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Beta2-adrenergic_receptor signaling in CD4 + Foxp3 + regulatory T cells enhances their suppressive function in a PKA-dependent manner .
23436577	0	Beta2-adrenergic_receptor	0,25	Foxp3	44,49	Beta2-adrenergic receptor	Foxp3	154	50943	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Beta2-adrenergic_receptor signaling in CD4 + Foxp3 + regulatory T cells enhances their suppressive function in a PKA-dependent manner .
18383370	0	Beta2-glycoprotein_I	0,20	thrombin	30,38	Beta2-glycoprotein I	thrombin	350	2147	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Beta2-glycoprotein_I protects thrombin from inhibition by heparin_cofactor_II : potentiation of this effect in the presence of anti-beta2-glycoprotein_I autoantibodies .
18227369	0	Beta2-microglobulin	0,19	cystatin_C	106,116	Beta2-microglobulin	cystatin C	567	1471	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Beta2-microglobulin for risk stratification of total mortality in the elderly population : comparison with cystatin_C and C-reactive_protein .
12580974	0	Beta2GPI	74,82	beta_2-glycoprotein_I	51,72	Beta2GPI	beta 2-glycoprotein I	350	350	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Paradoxical association between the 316_Trp_to_Ser beta_2-glycoprotein_I -LRB- Beta2GPI -RRB- polymorphism and anti-Beta2GPI antibodies .
12392575	0	BetaFTZ-F1	0,10	Edg78E	51,57	BetaFTZ-F1	Edg78E	40045(Tax:7227)	40354(Tax:7227)	Gene	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	BetaFTZ-F1 dependent and independent activation of Edg78E , a pupal cuticle gene , during the early metamorphic period in Drosophila_melanogaster .
17452648	0	BetaKlotho	0,10	fibroblast_growth_factor_21	49,76	BetaKlotho	fibroblast growth factor 21	83379(Tax:10090)	56636(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	BetaKlotho is required for metabolic activity of fibroblast_growth_factor_21 .
1830599	0	Beta_1_integrin	0,15	CD29	17,21	Beta 1 integrin	CD29	3688	3688	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Beta_1_integrin -LRB- CD29 -RRB- expression on human postnatal T cell subsets defined by selective CD45 isoform expression .
9973479	0	Beta_1_integrin	0,15	phospholipase_D	158,173	Beta 1 integrin	phospholipase D	3688	2822	Gene	Gene	activity|amod|START_ENTITY activity|dep|role role|nmod|END_ENTITY	Beta_1_integrin cross-linking inhibits CD16-induced phospholipase_D and secretory phospholipase A2 activity and granule exocytosis in human NK cells : role of phospholipase_D in CD16-triggered degranulation .
9973479	0	Beta_1_integrin	0,15	phospholipase_D	52,67	Beta 1 integrin	phospholipase D	3688	2822	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Beta_1_integrin cross-linking inhibits CD16-induced phospholipase_D and secretory phospholipase A2 activity and granule exocytosis in human NK cells : role of phospholipase_D in CD16-triggered degranulation .
7525608	0	Beta_2	0,6	paxillin	54,62	Beta 2	paxillin	10242	5829	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Beta_2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor .
22811690	0	Beta_2-microglobulin	6,26	cystatin_C	27,37	Beta 2-microglobulin	cystatin C	567	1471	Gene	Gene	index|dep|START_ENTITY index|amod|END_ENTITY	Serum Beta_2-microglobulin / cystatin_C index : a useful biomarker in lupus_nephritis ?
8024566	0	Beta_2-microglobulin	0,20	interleukin-6	75,88	Beta 2-microglobulin	interleukin-6	567	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Beta_2-microglobulin modified with advanced glycation end products induces interleukin-6 from human macrophages : role in the pathogenesis of hemodialysis-associated amyloidosis .
2887447	0	Beta_B1_crystallin	0,18	tissue_transglutaminase	51,74	Beta B1 crystallin	tissue transglutaminase	282205(Tax:9913)	281528(Tax:9913)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Beta_B1_crystallin is an amine-donor substrate for tissue_transglutaminase .
2956475	0	Beta_endorphin	0,14	CSF	25,28	Beta endorphin	CSF	5443	1437	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Beta_endorphin levels in CSF during methadone maintenance .
8645162	0	Betaglycan	0,10	transforming_growth_factor-beta_1	42,75	Betaglycan	transforming growth factor-beta 1	7049	7040	Gene	Gene	has|nsubj|START_ENTITY has|dobj|sites sites|nmod|END_ENTITY	Betaglycan has multiple binding sites for transforming_growth_factor-beta_1 .
12911636	0	Bex	33,36	olfactory_marker_protein	52,76	Bex	olfactory marker protein	27018	18378(Tax:10090)	Gene	Gene	family|compound|START_ENTITY family|nmod|END_ENTITY	Identification of members of the Bex gene family as olfactory_marker_protein -LRB- OMP -RRB- binding partners .
16314316	0	Bex2	6,10	LMO2	26,30	Bex2	LMO2	84707	4005	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex .
11959999	0	Bfa1	0,4	Bub2	49,53	Bfa1	Bub2	853513(Tax:4932)	855077(Tax:4932)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces_cerevisiae .
12700646	0	Bfk	0,3	Bcl-2	47,52	Bfk	Bcl-2	440603	596	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	Bfk : a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region .
15086420	0	Bfl-1	24,29	Bcl-2	4,9	Bfl-1	Bcl-2	597	596	Gene	Gene	A1|compound|START_ENTITY A1|amod|END_ENTITY	The Bcl-2 family member Bfl-1 / A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells .
18812174	0	Bfl-1	96,101	Bcl-2	53,58	Bfl-1	Bcl-2	597	596	Gene	Gene	structure|nmod|START_ENTITY portrait|dep|structure portrait|nmod|proteins proteins|compound|END_ENTITY	Completing the family portrait of the anti-apoptotic Bcl-2 proteins : crystal structure of human Bfl-1 in complex with Bim .
7478596	0	Bfl-1	28,33	Bcl-2	8,13	Bfl-1	Bcl-2	597	596	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel Bcl-2 related gene , Bfl-1 , is overexpressed in stomach_cancer and preferentially expressed in bone marrow .
9671389	0	Bfl-1	25,30	Bcl-2	34,39	Bfl-1	Bcl-2	597	596	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Functional dissection of Bfl-1 , a Bcl-2 homolog : anti-apoptosis , oncogene-cooperation and cell proliferation activities .
1653760	0	Bgp	37,40	biliary_glycoprotein	10,30	Bgp	biliary glycoprotein	26365(Tax:10090)	634	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse biliary_glycoprotein gene -LRB- Bgp -RRB- : partial nucleotide sequence , expression , and chromosomal assignment .
8500759	0	Bgp	18,21	biliary_glycoprotein	63,83	Bgp	biliary glycoprotein	26365(Tax:10090)	634	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Expression of the Bgp gene and characterization of mouse colon biliary_glycoprotein isoforms .
10964771	0	Bgp1	19,23	interferon-gamma	45,61	Bgp1	interferon-gamma	26365(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|dep|receptor receptor|nmod|END_ENTITY	Down-regulation of Bgp1 -LRB- a -RRB- viral receptor by interferon-gamma is related to the antiviral state and resistance to mouse hepatitis virus 3 infection .
14960307	0	BiP	26,29	FKBP23	10,16	BiP	FKBP23	14828(Tax:10090)	14231(Tax:10090)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2 + concentration .
17223077	0	BiP	39,42	FKBP23	15,21	BiP	FKBP23	14828(Tax:10090)	14231(Tax:10090)	Gene	Gene	activity|nmod:poss|START_ENTITY modulates|dobj|activity modulates|nsubj|The The|nmod|END_ENTITY	The binding of FKBP23 to BiP modulates BiP 's ATPase activity with its PPIase activity .
17425118	0	BiP	21,24	FKBP23	11,17	BiP	FKBP23	14828(Tax:10090)	14231(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of FKBP23 to BiP in ER shown by gel filtration chromatography .
21527244	0	BiP	54,57	FKBP23	6,12	BiP	FKBP23	14828(Tax:10090)	14231(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY mediates|dobj|functions mediates|nsubj|END_ENTITY	Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117 cis/trans isomerization .
11410313	0	BiP	11,14	GRP78	16,21	BiP	GRP78	3309	3309	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Changes in BiP -LRB- GRP78 -RRB- levels upon HSV-1 infection are strain dependent .
22446326	0	BiP	17,20	IRE1	50,54	BiP	IRE1	2662	2081	Gene	Gene	Binding|nmod|START_ENTITY transducers|nsubj|Binding transducers|ccomp|requires requires|nsubj|END_ENTITY	Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP .
15520230	0	BiP	11,14	Ire1	83,87	BiP	Ire1	3309	2081	Gene	Gene	role|nmod|START_ENTITY stress-sensing|nsubj|role stress-sensing|dobj|END_ENTITY	A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1 .
25692299	0	BiP	24,27	Ire1	45,49	BiP	Ire1	2662	2081	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling .
8423809	0	BiP	39,42	KAR2	33,37	BiP	KAR2	3309	853418(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The promoter region of the yeast KAR2 -LRB- BiP -RRB- gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum .
25473114	0	BiP	39,42	Sil1	0,4	BiP	Sil1	14828(Tax:10090)	81500(Tax:10090)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Sil1 , a nucleotide exchange factor for BiP , is not required for antibody assembly or secretion .
9207027	0	BiP	124,127	immunoglobulin_heavy-chain_binding_protein	80,122	BiP	immunoglobulin heavy-chain binding protein	3309	3309	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Location of the internal ribosome entry site in the 5 ' non-coding region of the immunoglobulin_heavy-chain_binding_protein -LRB- BiP -RRB- mRNA : evidence for specific RNA-protein interactions .
26075355	0	BiP	68,71	p62	94,97	BiP	p62	3309	8878	Gene	Gene	targets|dobj|START_ENTITY targets|nmod|END_ENTITY	Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding .
10970892	0	BiP	22,25	prion_protein	44,57	BiP	prion protein	3309	5621	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The chaperone protein BiP binds to a mutant prion_protein and mediates its degradation by the proteasome .
26740554	0	BiP	132,135	prion_protein	9,22	BiP	prion protein	2662	5621	Gene	Gene	depleting|dobj|START_ENTITY inhibit|advcl|depleting inhibit|nsubj|mutants mutants|compound|END_ENTITY	Familial prion_protein mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP .
20111007	0	Bicaudal-D	0,10	clathrin_heavy_chain	17,37	Bicaudal-D	clathrin heavy chain	35051(Tax:7227)	32537(Tax:7227)	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Bicaudal-D binds clathrin_heavy_chain to promote its transport and augments synaptic vesicle recycling .
21205795	0	Bicaudal_D	69,79	bicd-1	11,17	Bicaudal D	bicd-1	35051(Tax:7227)	183417(Tax:6239)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	C. _ elegans bicd-1 , homolog of the Drosophila dynein accessory factor Bicaudal_D , regulates the branching of PVD sensory neuron dendrites .
20187936	0	Bid	98,101	Akt	0,3	Bid	Akt	637	207	Gene	Gene	cleavage|compound|START_ENTITY inhibition|nmod|cleavage protects|nmod|inhibition protects|nsubj|activity activity|compound|END_ENTITY	Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage .
20661217	0	Bid	18,21	Akt	36,39	Bid	Akt	637	207	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian_cancer cells .
11585909	0	Bid	0,3	Bcl-2	52,57	Bid	Bcl-2	637	596	Gene	Gene	START_ENTITY|appos|protein protein|nmod|family family|compound|END_ENTITY	Bid , a widely expressed proapoptotic protein of the Bcl-2 family , displays lipid transfer activity .
20088789	0	Bid	0,3	COX-2	28,33	Bid	COX-2	12122(Tax:10090)	17709(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|compound|END_ENTITY	Bid mediates anti-apoptotic COX-2 induction through the IKKbeta/NFkappaB pathway due to 5-MCDE exposure .
15075251	0	Bid	67,70	FAN	49,52	Bid	FAN	64625(Tax:10116)	353233(Tax:10116)	Gene	Gene	dependent|dep|START_ENTITY END_ENTITY|parataxis|dependent	TNF-alpha-mediated lysosomal permeabilization is FAN and caspase_8 / Bid dependent .
16380381	0	Bid	31,34	Mcl-1	0,5	Bid	Mcl-1	637	4170	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome_c release and its role in receptor-mediated apoptosis .
26779944	0	Bid	86,89	Mcl-1	80,85	Bid	Mcl-1	637	4170	Gene	Gene	interaction|nsubj|START_ENTITY Kingianins_O-Q|parataxis|interaction Kingianins_O-Q|dep|polyketides polyketides|nmod|kingiana kingiana|nmod|inhibitor inhibitor|nmod|END_ENTITY	Kingianins_O-Q : Pentacyclic polyketides from Endiandra kingiana as inhibitor of Mcl-1 / Bid interaction .
18665919	0	Bid	49,52	Thrombin	0,8	Bid	Thrombin	637	2147	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Thrombin induces activation and translocation of Bid , Bax and Bak to the mitochondria in human platelets .
12196516	0	Bid	145,148	caspase-8	57,66	Bid	caspase-8	12122(Tax:10090)	12370(Tax:10090)	Gene	Gene	signal|nmod|START_ENTITY signal|xcomp|END_ENTITY	TRAIL receptor and CD95 signal to mitochondria via FADD , caspase-8 / 10 , Bid , and Bax but differentially regulate events downstream from truncated Bid .
15579484	0	Bid	28,31	caspase-8	18,27	Bid	caspase-8	637	841	Gene	Gene	pathways|nsubj|START_ENTITY Activation|parataxis|pathways Activation|nmod|END_ENTITY	Activation of the caspase-8 / Bid and Bax pathways in aspirin-induced apoptosis in gastric_cancer .
17431792	0	Bid	0,3	caspase-8	27,36	Bid	caspase-8	637	841	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|advmod|upstream upstream|nmod|activation activation|amod|END_ENTITY	Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells .
20356928	0	Bid	41,44	caspase-8	59,68	Bid	caspase-8	637	841	Gene	Gene	Activity|nmod|START_ENTITY cleavage|nsubj|Activity cleavage|nmod|activation activation|amod|END_ENTITY	Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation .
10973993	0	Bid	59,62	cytochrome_c	80,92	Bid	cytochrome c	637	54205	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Preservation of mitochondrial structure and function after Bid - or Bax-mediated cytochrome_c release .
18752120	0	Bif-1	50,55	Bax-interacting_factor-1	24,48	Bif-1	Bax-interacting factor-1	51100	51100	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of Bax-interacting_factor-1 -LRB- Bif-1 -RRB- in invasive urinary bladder and gallbladder_cancers .
17891140	0	Bif-1	0,5	Beclin_1	21,29	Bif-1	Beclin 1	51100	8678	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Bif-1 interacts with Beclin_1 through UVRAG and regulates autophagy and tumorigenesis .
18474606	0	Bif-1	28,33	SRC	0,3	Bif-1	SRC	268294(Tax:10090)	20779(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis .
17891140	0	Bif-1	0,5	UVRAG	38,43	Bif-1	UVRAG	51100	7405	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Bif-1 interacts with Beclin_1 through UVRAG and regulates autophagy and tumorigenesis .
27034473	0	Biglycan	8,16	Thrombin	26,34	Biglycan	Thrombin	12111(Tax:10090)	14061(Tax:10090)	Gene	Gene	Generation|compound|START_ENTITY Generation|compound|END_ENTITY	Loss of Biglycan Enhances Thrombin Generation in ApoE-Deficient Mice Implications for Inflammation and Atherosclerosis .
22982459	0	Biglycan	0,8	Toll-like_receptor-2	99,119	Biglycan	Toll-like receptor-2	633	7097	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like_receptor-2 .
25371074	0	Biglycan	0,8	VEGF	58,62	Biglycan	VEGF	633	7422	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Biglycan up-regulated vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and promoted angiogenesis in colon_cancer .
27072616	0	Biglycan	0,8	endostatin	106,116	Biglycan	endostatin	12111(Tax:10090)	12822(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|altering altering|dobj|expression expression|nmod|END_ENTITY	Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin .
20602574	0	Bikunin	0,7	AMBP	48,52	Bikunin	AMBP	259	259	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Bikunin and a1-microglobulin/bikunin _ precursor -LRB- AMBP -RRB- gene mutational screening in patients with kidney_stones : a case-control study .
15539519	0	Bikunin	0,7	tumor_necrosis_factor_alpha	44,71	Bikunin	tumor necrosis factor alpha	259	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|compound|END_ENTITY	Bikunin inhibits lipopolysaccharide-induced tumor_necrosis_factor_alpha induction in macrophages .
22659879	0	Bim	39,42	Angiotensin_II	0,14	Bim	Angiotensin II	10018	183	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Angiotensin_II regulates activation of Bim via Rb/E2F1 during apoptosis : involvement of interaction between AMPKb1/2 and Cdk4 .
24632712	0	Bim	114,117	BH3-only	96,104	Bim	BH3-only	12125(Tax:10090)	170770(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Deregulated cell death and lymphocyte homeostasis cause premature_lethality in mice lacking the BH3-only proteins Bim and Bmf .
11154272	0	Bim	18,21	Bcl-2	50,55	Bim	Bcl-2	12125(Tax:10090)	12043(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|appos|relative relative|nmod|END_ENTITY	Downregulation of Bim , a proapoptotic relative of Bcl-2 , is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors .
11210187	0	Bim	98,101	Bcl-2	83,88	Bim	Bcl-2	12125(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Gene structure alternative splicing , and chromosomal localization of pro-apoptotic Bcl-2 relative Bim .
11734221	0	Bim	70,73	Bcl-2	104,109	Bim	Bcl-2	10018	596	Gene	Gene	isoforms|nmod|START_ENTITY cloning|nmod|isoforms cloning|appos|member member|nmod|family family|compound|END_ENTITY	Molecular cloning and characterization of six novel isoforms of human Bim , a member of the proapoptotic Bcl-2 family .
14970329	0	Bim	56,59	Bcl-2	28,33	Bim	Bcl-2	10018	596	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|nmod|member member|compound|END_ENTITY	Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering .
16394656	0	Bim	8,11	Bcl-2	22,27	Bim	Bcl-2	12125(Tax:10090)	12043(Tax:10090)	Gene	Gene	members|compound|START_ENTITY members|compound|END_ENTITY	Role of Bim and other Bcl-2 family members in autoimmune and degenerative_diseases .
16780816	0	Bim	55,58	Bcl-2	34,39	Bim	Bcl-2	12125(Tax:10090)	12043(Tax:10090)	Gene	Gene	members|amod|START_ENTITY members|amod|END_ENTITY	Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia .
18812174	0	Bim	118,121	Bcl-2	53,58	Bim	Bcl-2	10018	596	Gene	Gene	Completing|nmod|START_ENTITY Completing|dobj|portrait portrait|nmod|proteins proteins|compound|END_ENTITY	Completing the family portrait of the anti-apoptotic Bcl-2 proteins : crystal structure of human Bfl-1 in complex with Bim .
19950021	0	Bim	59,62	Bcl-2	38,43	Bim	Bcl-2	12125(Tax:10090)	12043(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3 .
21451108	0	Bim	79,82	Bcl-2	0,5	Bim	Bcl-2	10018	596	Gene	Gene	expression|nmod|START_ENTITY tolerate|dobj|expression allows|xcomp|tolerate allows|nsubj|END_ENTITY	Bcl-2 allows effector and memory CD8 + T cells to tolerate higher expression of Bim .
22065578	0	Bim	52,55	Bcl-2	108,113	Bim	Bcl-2	12125(Tax:10090)	12043(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|acl:relcl|interacts interacts|nmod|END_ENTITY	Natural diterpenoid compound elevates expression of Bim protein , which interacts with antiapoptotic protein Bcl-2 , converting it to proapoptotic Bax-like molecule .
23235460	0	Bim	50,53	Bcl-2	92,97	Bim	Bcl-2	10018	596	Gene	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist .
9430630	0	Bim	0,3	Bcl-2	27,32	Bim	Bcl-2	10018	596	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	Bim : a novel member of the Bcl-2 family that promotes apoptosis .
18549468	0	Bim	80,83	Bcl2L11	71,78	Bim	Bcl2L11	10018	10018	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a candidate alternative promoter region of the human Bcl2L11 -LRB- Bim -RRB- gene .
22071694	0	Bim	46,49	Cyclin_B1	0,9	Bim	Cyclin B1	10018	891	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cyclin_B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis .
22572381	0	Bim	62,65	DEC2	26,30	Bim	DEC2	10018	79365	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral_cancer HSC-3 cells .
16301744	0	Bim	76,79	ERK	88,91	Bim	ERK	12125(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway .
17105963	0	Bim	14,17	ERK	64,67	Bim	ERK	12125(Tax:10090)	26413(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY mediated|nsubjpass|phosphorylation mediated|nmod|END_ENTITY	TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein .
26721325	0	Bim	112,115	ERK1/2	44,50	Bim	ERK1/2	10018	5595;5594	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Pseudorabies_virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells .
26716515	0	Bim	91,94	Erk1/2	110,116	Bim	Erk1/2	10018	5595;5594	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Mitotic cell death caused by follistatin-like_1 inhibition is associated with up-regulated Bim by inactivated Erk1/2 in human lung_cancer cells .
24550147	0	Bim	27,30	FGFR4	0,5	Bim	FGFR4	10018	2264	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	FGFR4 signaling couples to Bim and not Bmf to discriminate subsets of alveolar_rhabdomyosarcoma cells .
18465250	0	Bim	94,97	FOXO3a	59,65	Bim	FOXO3a	64547(Tax:10116)	294515(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY activation|nmod|transcription activation|amod|END_ENTITY	p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription .
14527951	0	Bim	37,40	FoxO3a	0,6	Bim	FoxO3a	10018	2309	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast_cancer cell lines .
23257900	0	Bim	48,51	FoxO3a	55,61	Bim	FoxO3a	10018	2309	Gene	Gene	regulation|nmod|START_ENTITY induces|dobj|regulation induces|nmod|END_ENTITY	Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells .
22572381	0	Bim	62,65	HSC-3	87,92	Bim	HSC-3	10018	150353	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral_cancer HSC-3 cells .
19933849	0	Bim	24,27	Interleukin-7	0,13	Bim	Interleukin-7	12125(Tax:10090)	16196(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival .
21977009	0	Bim	106,109	Mcl-1	112,117	Bim	Mcl-1	10018	4170	Gene	Gene	imbalance|compound|START_ENTITY imbalance|compound|END_ENTITY	Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance .
22270368	0	Bim	39,42	Mcl-1	89,94	Bim	Mcl-1	10018	4170	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase -LRB- MEK -RRB- inhibitor and microtubule inhibitor .
25437618	0	Bim	120,123	Mcl-1	89,94	Bim	Mcl-1	10018	4170	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Design , synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1 / Bcl-xL inhibitors .
22076535	0	Bim	40,43	MiR-25	0,6	Bim	MiR-25	10018	407014	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-25 regulates apoptosis by targeting Bim in human ovarian_cancer .
14676826	0	Bim	8,11	Raf	47,50	Bim	Raf	10018	22882	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of Bim in the survival pathway induced by Raf in epithelial cells .
16778834	0	Bim	18,21	TrkB	73,77	Bim	TrkB	10018	4915	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Downregulation of Bim by brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death .
16778834	0	Bim	18,21	brain-derived_neurotrophic_factor	25,58	Bim	brain-derived neurotrophic factor	10018	627	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Downregulation of Bim by brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death .
22728771	0	Bim	22,25	interleukin-7	127,140	Bim	interleukin-7	10018	3574	Gene	Gene	isoforms|nmod|START_ENTITY contribute|nsubj|isoforms contribute|nmod|activities activities|acl:relcl|govern govern|nmod|lymphocytes lymphocytes|amod|END_ENTITY	The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes .
18590831	0	Bim1p	53,58	EB1	16,19	Bim1p	EB1	856736(Tax:4932)	22919	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Giardia_lamblia EB1 is a functional homolog of yeast Bim1p that binds to microtubules .
10380878	0	Bin1	0,4	Myc	33,36	Bin1	Myc	274	4609	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms .
10412034	0	Bin1	107,111	Myc	121,124	Bin1	Myc	274	4609	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1 , a novel Myc interacting protein .
24435510	0	Binder_of_SPerm_Homolog_1	25,50	BSPH1	52,57	Binder of SPerm Homolog 1	BSPH1	100131137	100131137	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Implication of the human Binder_of_SPerm_Homolog_1 -LRB- BSPH1 -RRB- protein in capacitation .
25183008	0	Biogenesis_of_lysosome-related_organelles_complex-1_subunit_1	0,61	sorting_nexin_2	85,100	Biogenesis of lysosome-related organelles complex-1 subunit 1	sorting nexin 2	14533(Tax:10090)	67804(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Biogenesis_of_lysosome-related_organelles_complex-1_subunit_1 -LRB- BLOS1 -RRB- interacts with sorting_nexin_2 and the endosomal sorting complex required for transport-I -LRB- ESCRT-I -RRB- component TSG101 to mediate the sorting of epidermal_growth_factor_receptor into endosomal compartments .
17652458	0	Bir1p	2,7	Sli15p	8,14	Bir1p	Sli15p	853551(Tax:4932)	852453(Tax:4932)	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	A Bir1p Sli15p kinetochore passenger complex regulates septin organization during anaphase .
25800559	0	Birc-8	61,67	ILP-2	68,73	Birc-8	ILP-2	112401	112401	Gene	Gene	/|amod|START_ENTITY END_ENTITY|amod|/	Fumonisin_B inhibits apoptosis in HepG2 cells by inducing Birc-8 / ILP-2 .
14769940	0	Birt-Hogg-Dub	29,42	BHD	46,49	Birt-Hogg-Dub	BHD	303185(Tax:10116)	303185(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A germ-line insertion in the Birt-Hogg-Dub -LRB- BHD -RRB- gene gives rise to the Nihon rat model of inherited_renal_cancer .
18218778	0	Bit1	17,21	Erk	43,46	Bit1	Erk	217057(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Anoikis effector Bit1 negatively regulates Erk activity .
25368383	0	Bithorax_Complex	82,98	CTCF	20,24	Bithorax Complex	CTCF	42034(Tax:7227)	38817(Tax:7227)	Gene	Gene	Site|nmod|START_ENTITY Site|compound|END_ENTITY	A Variably Occupied CTCF Binding Site in the Ultrabithorax Gene in the Drosophila Bithorax_Complex .
26311219	0	Bithorax_complex	43,59	Hox	0,3	Bithorax complex	Hox	42034(Tax:7227)	42536(Tax:7227)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Hox miRNA regulation within the Drosophila Bithorax_complex : Patterning behavior .
10477288	0	Bix4	0,4	VegT	30,34	Bix4	VegT	398077(Tax:8355)	397990(Tax:8355)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development .
1848579	0	Blast-1	18,25	CD48	81,85	Blast-1	CD48	962	962	Gene	Gene	molecule|compound|START_ENTITY Expression|nmod|molecule Expression|nmod|END_ENTITY	Expression of the Blast-1 activation/adhesion molecule and its identification as CD48 .
1999350	0	Blast-1	87,94	CD48	28,32	Blast-1	CD48	962	962	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	The human leucocyte antigen CD48 -LRB- MEM-102 -RRB- is closely related to the activation marker Blast-1 .
26823144	0	Blimp-1	25,32	Aiolos	0,6	Blimp-1	Aiolos	639	22806	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	Aiolos collaborates with Blimp-1 to regulate the survival of multiple_myeloma cells .
16040253	0	Blimp-1	43,50	B-lymphocyte-induced_maturation_protein-1	0,41	Blimp-1	B-lymphocyte-induced maturation protein-1	446070(Tax:31033)	446070(Tax:31033)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	B-lymphocyte-induced_maturation_protein-1 -LRB- Blimp-1 -RRB- gene of torafugu -LRB- Takifugu_rubripes -RRB- .
24968003	0	Blimp-1	7,14	BLMP-1	0,6	Blimp-1	BLMP-1	639	172917(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	BLMP-1 / Blimp-1 regulates the spatiotemporal cell migration pattern in C. _ elegans .
9687529	0	Blimp-1	64,71	B_lymphocyte-induced_maturation_protein	23,62	Blimp-1	B lymphocyte-induced maturation protein	639	639	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Differential effect of B_lymphocyte-induced_maturation_protein -LRB- Blimp-1 -RRB- expression on cell fate during B cell development .
12204275	0	Blimp-1	77,84	B_lymphocyte_induced_maturation_protein-1	34,75	Blimp-1	B lymphocyte induced maturation protein-1	12142(Tax:10090)	12142(Tax:10090)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	The dynamic expression pattern of B_lymphocyte_induced_maturation_protein-1 -LRB- Blimp-1 -RRB- during mouse embryonic development .
18256039	0	Blimp-1	51,58	Bach2	67,72	Blimp-1	Bach2	639	60468	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6 .
22745171	0	Blimp-1	70,77	CD8	85,88	Blimp-1	CD8	639	925	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8 + T cell .
24590765	0	Blimp-1	0,7	CD8	18,21	Blimp-1	CD8	639	925	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral_infection .
23977359	0	Blimp-1	16,23	IFN-a	0,5	Blimp-1	IFN-a	639	3438	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-a regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC .
17182561	0	Blimp-1	19,26	IL-2	68,72	Blimp-1	IL-2	639	3558	Gene	Gene	expression|compound|START_ENTITY inhibits|nsubj|expression inhibits|dobj|production production|compound|END_ENTITY	Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production .
22585398	0	Blimp-1	79,86	IL-2	15,19	Blimp-1	IL-2	639	3558	Gene	Gene	repressing|dobj|START_ENTITY enhances|dep|repressing enhances|dobj|production production|compound|END_ENTITY	miR-9 enhances IL-2 production in activated human CD4 -LRB- + -RRB- T cells by repressing Blimp-1 .
25015830	0	Blimp-1	18,25	IL-2	0,4	Blimp-1	IL-2	639	3558	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IL-2 induction of Blimp-1 is a key in vivo signal for CD8 + short-lived effector T cell differentiation .
18725523	0	Blimp-1	0,7	Il2	27,30	Blimp-1	Il2	12142(Tax:10090)	16183(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Blimp-1 directly represses Il2 and the Il2 activator Fos , attenuating T cell proliferation and survival .
24590765	0	Blimp-1	0,7	PD-1	43,47	Blimp-1	PD-1	639	5133	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral_infection .
19234190	0	Blimp-1	0,7	PRDM1	8,13	Blimp-1	PRDM1	639	639	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Blimp-1 / PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch -1 .
26310579	0	Blimp-1	0,7	PRDM1	8,13	Blimp-1	PRDM1	639	639	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Blimp-1 / PRDM1 regulates the transcription of human CS1 -LRB- SLAMF7 -RRB- gene in NK and B cells .
17877160	0	Blimp-1	35,42	c-myc	15,20	Blimp-1	c-myc	639	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Regulation of c-myc expression by Blimp-1 during the differentiation of myeloma cells -RSB- .
9110979	0	Blimp-1	37,44	c-myc	14,19	Blimp-1	c-myc	639	4609	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|transcription transcription|amod|END_ENTITY	Repression of c-myc transcription by Blimp-1 , an inducer of terminal B cell differentiation .
19828640	0	Blimp-1	61,68	positive_regulatory_domain_I-binding_factor_1	15,60	Blimp-1	positive regulatory domain I-binding factor 1	639	639	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	PU .1 regulates positive_regulatory_domain_I-binding_factor_1 / Blimp-1 transcription in lymphoma cells .
20463215	0	Blimp1	0,6	Chx10	18,23	Blimp1	Chx10	12142(Tax:10090)	12677(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development .
16699504	0	Blimp1	0,6	Prmt5	23,28	Blimp1	Prmt5	12142(Tax:10090)	27374(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells .
21039888	0	BlyS	65,69	TLR7	0,4	BlyS	TLR7	10673	51284	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TLR7 regulates dendritic cell-dependent B-cell responses through BlyS in immune thrombocytopenic_purpura .
27001963	0	BmFMBP-1	21,29	Bmo-miR-2758	0,12	BmFMBP-1	Bmo-miR-2758	692516(Tax:7091)	102464378	Gene	Gene	Targets|dobj|START_ENTITY Targets|nsubj|END_ENTITY	Bmo-miR-2758 Targets BmFMBP-1 -LRB- Lepidoptera : Bombycidae -RRB- and Suppresses Its Expression in BmN Cells .
26151099	0	Bmal1	137,142	ERK	176,179	Bmal1	ERK	29657(Tax:10116)	24338(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The induction of Per1 expression by the combined treatment with glutamate , 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes .
21030946	0	Bmal1	21,26	clock	10,15	Bmal1	clock	11865(Tax:10090)	12753(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Impact of clock gene Bmal1 deficiency on nutritionally induced obesity in mice .
22700438	0	Bmal1	22,27	clock	10,15	Bmal1	clock	374115(Tax:9031)	373991(Tax:9031)	Gene	Gene	START_ENTITY|nsubj|genes genes|compound|END_ENTITY	Circadian clock genes Bmal1 and Clock during early chick development .
21638011	0	Bmi-1	0,5	Bmi-1	92,97	Bmi-1	Bmi-1	648	648	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Bmi-1 , c-myc , and Snail expression in primary breast_cancers and their metastases -- elevated Bmi-1 expression in late breast_cancer relapses .
21638011	0	Bmi-1	92,97	Bmi-1	0,5	Bmi-1	Bmi-1	648	648	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Bmi-1 , c-myc , and Snail expression in primary breast_cancers and their metastases -- elevated Bmi-1 expression in late breast_cancer relapses .
17974970	0	Bmi-1	0,5	H-Ras	22,27	Bmi-1	H-Ras	648	3265	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways .
26452029	0	Bmi-1	61,66	Hes1	0,4	Bmi-1	Hes1	648	3280	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3b pathway in human colon_cancer .
22777769	0	Bmi-1	32,37	IGF-IR	67,73	Bmi-1	IGF-IR	648	3480	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	VEGF/neuropilin -2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive_prostate_cancer .
14536079	0	Bmi-1	0,5	INK4A-ARF	20,29	Bmi-1	INK4A-ARF	648	1029	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1 .
17148591	0	Bmi-1	0,5	LMP1	52,56	Bmi-1	LMP1	648	9260	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Bmi-1 is induced by the Epstein-Barr_virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin_lymphoma cells .
19884659	0	Bmi-1	27,32	PTEN	64,68	Bmi-1	PTEN	648	5728	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells .
17557835	0	Bmi-1	0,5	SALL4	27,32	Bmi-1	SALL4	12151(Tax:10090)	99377(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells .
20936121	0	Bmi-1	0,5	Snail	16,21	Bmi-1	Snail	648	6615	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells .
25262972	0	Bmi-1	0,5	p16	67,70	Bmi-1	p16	648	1029	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Bmi-1 regulates the migration and invasion of glioma cells through p16 .
25832744	0	Bmi-1	21,26	p16	27,30	Bmi-1	p16	12151(Tax:10090)	12578(Tax:10090)	Gene	Gene	Dysregulation|nmod|START_ENTITY Dysregulation|parataxis|provokes provokes|nsubj|END_ENTITY	Dysregulation of the Bmi-1 / p16 -LRB- Ink4a -RRB- pathway provokes an aging-associated decline of submandibular gland function .
14560011	0	Bmi1	43,47	Cited2	28,34	Bmi1	Cited2	12151(Tax:10090)	17684(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF .
17214966	0	Bmi1	0,4	Dnmt1-associated_protein_1	21,47	Bmi1	Dnmt1-associated protein 1	648	55929	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Bmi1 cooperates with Dnmt1-associated_protein_1 in gene silencing .
21221124	0	Bmi1	23,27	IL-10	49,54	Bmi1	IL-10	648	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages .
20190806	0	Bmi1	0,4	MYCN	10,14	Bmi1	MYCN	648	4613	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma .
26137120	0	Bmi1	71,75	MicroRNA-203	0,12	Bmi1	MicroRNA-203	648	406986	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small_cell_lung_cancer .
21402923	0	Bmi1	56,60	Polycomb	36,44	Bmi1	Polycomb	648	12416(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|function function|nmod|gene gene|compound|END_ENTITY	An anticlastogenic function for the Polycomb Group gene Bmi1 .
25379404	0	Bmi1	22,26	Polycomb	4,12	Bmi1	Polycomb	12151(Tax:10090)	12416(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The Polycomb protein , Bmi1 , regulates insulin sensitivity .
17249577	1	Bmi1	57,61	Rd1	90,93	Bmi1	Rd1	12151(Tax:10090)	18587(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Bmi1 loss and neuroprotection in Rd1 mice .
25903073	0	Bmi1	9,13	miR-200c	0,8	Bmi1	miR-200c	648	406985	Gene	Gene	Axis|compound|START_ENTITY Axis|amod|END_ENTITY	miR-200c / Bmi1 Axis and Epithelial-Mesenchymal Transition Contribute to Acquired Resistance to BRAF Inhibitor Treatment .
22509111	0	Bmi1	50,54	p16INK4a	19,27	Bmi1	p16INK4a	648	1029	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	High expression of p16INK4a and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea .
27001963	0	Bmo-miR-2758	0,12	BmFMBP-1	21,29	Bmo-miR-2758	BmFMBP-1	102464378	692516(Tax:7091)	Gene	Gene	Targets|nsubj|START_ENTITY Targets|dobj|END_ENTITY	Bmo-miR-2758 Targets BmFMBP-1 -LRB- Lepidoptera : Bombycidae -RRB- and Suppresses Its Expression in BmN Cells .
23396188	0	Bmp	30,33	Beta-catenin	0,12	Bmp	Beta-catenin	649	1499	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Beta-catenin -LRB- CTNNB1 -RRB- induces Bmp expression in urogenital_sinus epithelium and participates in prostatic bud initiation and patterning .
9199359	0	Bmp-4	0,5	morphogen	16,25	Bmp-4	morphogen	397874(Tax:8355)	398047(Tax:8355)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus .
23863480	0	Bmp10	12,17	Alk1	43,47	Bmp10	Alk1	562533(Tax:7955)	266753(Tax:7955)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence .
15765505	0	Bmp2	29,33	Runx2	0,5	Bmp2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development .
24111778	0	Bmp4	0,4	Ebf2	21,25	Bmp4	Ebf2	396165(Tax:9031)	395176(Tax:9031)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Bmp4 regulates chick Ebf2 and Ebf3 gene expression in somite development .
23720046	0	Bmp4	40,44	Msx1	0,4	Bmp4	Msx1	12159(Tax:10090)	17701(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development .
17359964	0	Bmp4	17,21	Noggin	0,6	Bmp4	Noggin	12159(Tax:10090)	18121(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Noggin regulates Bmp4 activity during pituitary induction .
20059955	0	Bmp4	92,96	SCX	74,77	Bmp4	SCX	652	642658	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton_junction .
20858598	0	Bmp4	43,47	Shox2	0,5	Bmp4	Shox2	12159(Tax:10090)	20429(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY mediates|advcl|regulating mediates|nsubj|END_ENTITY	Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart .
21123999	0	Bmp4	16,20	Tbx1	30,34	Bmp4	Tbx1	652	6899	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling .
10964473	0	Bmp4	42,46	glypican-3	0,10	Bmp4	glypican-3	12159(Tax:10090)	14734(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development .
18539898	0	Bmp6	67,71	Smad1/5/8	34,43	Bmp6	Smad1/5/8	12161(Tax:10090)	17125;17129;55994	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6 , Smad7 , Id1 , and Atoh8 in the mouse liver .
20375015	0	Bmp7	140,144	NFAT2	116,121	Bmp7	NFAT2	12162(Tax:10090)	18018(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of embryonic_kidney branching morphogenesis and glomerular development by KISS1_receptor -LRB- Gpr54 -RRB- through NFAT2 - and Sp1-mediated Bmp7 expression .
19820125	0	Bmp7	30,34	Trps1	0,5	Bmp7	Trps1	12162(Tax:10090)	83925(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	Trps1 functions downstream of Bmp7 in kidney development .
19733164	0	Bmpr1a	26,32	BMP	11,14	Bmpr1a	BMP	657	649	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	The type I BMP receptors , Bmpr1a and Acvr1 , activate multiple signaling pathways to regulate lens formation .
19731076	0	Bmrbp1	45,51	rbp1	103,107	Bmrbp1	rbp1	733053(Tax:7091)	41294(Tax:7227)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and expression analysis of Bmrbp1 , the Bombyx_mori homologue of the Drosophila gene rbp1 .
11565748	0	Bms1p	0,5	Rcl1p	54,59	Bms1p	Rcl1p	855884(Tax:4932)	854152(Tax:4932)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Bms1p , a G-domain-containing protein , associates with Rcl1p and is required for 18S rRNA biogenesis in yeast .
18402776	0	Bmx	0,3	IL-6	26,30	Bmx	IL-6	660	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts .
22918946	0	Bni1p	38,43	Cdc42p	0,6	Bni1p	Cdc42p	855450(Tax:4932)	850930(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p .
9082982	0	Bni1p	0,5	cdc42p	30,36	Bni1p	cdc42p	855450(Tax:4932)	850930(Tax:4932)	Gene	Gene	formin|advmod|START_ENTITY formin|xcomp|linking linking|dobj|END_ENTITY	Bni1p , a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis .
17447897	0	Bnip3	0,5	Bax	64,67	Bnip3	Bax	12176(Tax:10090)	12028(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Bnip3 mediates mitochondrial_dysfunction and cell death through Bax and Bak .
18096822	0	Bnip3	38,43	E2F-1	22,27	Bnip3	E2F-1	664	1869	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes .
20436456	0	Bnip3	13,18	Opa1	40,44	Bnip3	Opa1	664	4976	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial_fragmentation and apoptosis by distinct mechanisms .
15607964	0	Bnip3L	0,6	p53	21,24	Bnip3L	p53	665	7157	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Bnip3L is induced by p53 under hypoxia , and its knockdown promotes tumor growth .
22185759	0	Bok	65,68	Myocardin-related_transcription_factor_A	0,40	Bok	Myocardin-related transcription factor A	666	57591	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Myocardin-related_transcription_factor_A regulates expression of Bok and Noxa and is involved in apoptotic signalling .
16267018	0	Bombesin	0,8	Egr-1	82,87	Bombesin	Egr-1	2922	1958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Bombesin regulates cyclin_D1 expression through the early_growth_response_protein Egr-1 in prostate_cancer cells .
16267018	0	Bombesin	0,8	cyclin_D1	19,28	Bombesin	cyclin D1	2922	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Bombesin regulates cyclin_D1 expression through the early_growth_response_protein Egr-1 in prostate_cancer cells .
16909108	0	Bombesin	0,8	cyclooxygenase-2	17,33	Bombesin	cyclooxygenase-2	2922	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon_carcinoma cells .
7457732	0	Bombesin	0,8	gastrin	46,53	Bombesin	gastrin	2922	2520	Gene	Gene	START_ENTITY|dep|stimulator stimulator|nmod|release release|compound|END_ENTITY	Bombesin : a vagally independent stimulator of gastrin release .
3518864	0	Bombesin	0,8	growth_hormone	18,32	Bombesin	growth hormone	2922	2688	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|response response|amod|END_ENTITY	Bombesin inhibits growth_hormone response to insulin-induced hypoglycemia in humans .
6828206	0	Bombesin	0,8	growth_hormone	20,34	Bombesin	growth hormone	2922	81668(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Bombesin stimulates growth_hormone secretion from cultured bovine pituitary cells .
27059954	0	Bone_Morphogenetic_Protein	28,54	Fibrillin-1	93,104	Bone Morphogenetic Protein	Fibrillin-1	649	2200	Gene	Gene	Activity|compound|START_ENTITY Regulation|nmod|Activity Regulation|nmod|END_ENTITY	Extracellular Regulation of Bone_Morphogenetic_Protein Activity by the Microfibril Component Fibrillin-1 .
23983792	0	Bone_Morphogenetic_Protein-2	165,193	Runx2	209,214	Bone Morphogenetic Protein-2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone_Morphogenetic_Protein-2 / Smad-Dependent Runx2 Pathway .
18282670	0	Bone_Morphogenetic_Protein_15	24,53	BMP15	55,60	Bone Morphogenetic Protein 15	BMP15	100141303(Tax:9940)	100141303(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A 17 bp deletion in the Bone_Morphogenetic_Protein_15 -LRB- BMP15 -RRB- gene is associated to increased prolificacy in the Rasa Aragonesa sheep breed .
25077038	0	Bone_Morphogenetic_Protein_3	11,39	BMP3	41,45	Bone Morphogenetic Protein 3	BMP3	651	651	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Methylated Bone_Morphogenetic_Protein_3 -LRB- BMP3 -RRB- Gene : Evaluation of Tumor_Suppressor Function and Biomarker Potential in Biliary_Cancer .
25504218	0	Bone_Sialoprotein	43,60	Runt-Related_Transcription_Factor_2	108,143	Bone Sialoprotein	Runt-Related Transcription Factor 2	3381	860	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Oxidized Low-Density Lipoprotein Increases Bone_Sialoprotein Expression in Vascular Smooth Muscle Cells Via Runt-Related_Transcription_Factor_2 .
11445007	0	Bone_morphogenetic_protein-2	0,28	Dlx-2	114,119	Bone morphogenetic protein-2	Dlx-2	12156(Tax:10090)	13392(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2 .
11788714	0	Bone_morphogenetic_protein-2	0,28	Dlx3	52,56	Bone morphogenetic protein-2	Dlx3	12156(Tax:10090)	13393(Tax:10090)	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- transactivates Dlx3 through Smad1 and Smad4 : alternative mode for Dlx3 induction in mouse keratinocytes .
20825377	0	Bone_morphogenetic_protein-2	0,28	FSH_receptor	66,78	Bone morphogenetic protein-2	FSH receptor	650	2492	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- increases gene expression of FSH_receptor and aromatase and decreases gene expression of LH_receptor and StAR in human granulosa cells .
16613856	0	Bone_morphogenetic_protein-2	0,28	Runx2	40,45	Bone morphogenetic protein-2	Runx2	650	860	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|acetylation acetylation|amod|END_ENTITY	Bone_morphogenetic_protein-2 stimulates Runx2 acetylation .
15526281	0	Bone_morphogenetic_protein-2	0,28	ZNF450	91,97	Bone morphogenetic protein-2	ZNF450	12156(Tax:10090)	268294(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Bone_morphogenetic_protein-2 induces expression of murine zinc finger transcription factor ZNF450 .
19341710	0	Bone_morphogenetic_protein-2	0,28	miR-206	44,51	Bone morphogenetic protein-2	miR-206	12156(Tax:10090)	387202(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Bone_morphogenetic_protein-2 down-regulates miR-206 expression by blocking its maturation process .
19170762	0	Bone_morphogenetic_protein-2	0,28	osteoprotegerin	73,88	Bone morphogenetic protein-2	osteoprotegerin	12156(Tax:10090)	18383(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Bone_morphogenetic_protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression .
12647290	0	Bone_morphogenetic_protein-2	0,28	osterix	38,45	Bone morphogenetic protein-2	osterix	12156(Tax:10090)	170574(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Bone_morphogenetic_protein-2 enhances osterix gene expression in chondrocytes .
10903423	0	Bone_morphogenetic_protein-2	0,28	p21	61,64	Bone morphogenetic protein-2	p21	650	1026	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Bone_morphogenetic_protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast_cancer cells .
19450561	0	Bone_morphogenetic_protein-4	0,28	MMP-9	66,71	Bone morphogenetic protein-4	MMP-9	652	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Bone_morphogenetic_protein-4 induced by NDRG2 expression inhibits MMP-9 activity in breast_cancer cells .
20093492	0	Bone_morphogenetic_protein-7	0,28	Smad3	71,76	Bone morphogenetic protein-7	Smad3	655	4088	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Bone_morphogenetic_protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression .
12594282	0	Bone_morphogenetic_protein-7	0,28	monocyte_chemoattractant_protein-1	82,116	Bone morphogenetic protein-7	monocyte chemoattractant protein-1	655	6347	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Bone_morphogenetic_protein-7 inhibits constitutive and interleukin-1_beta-induced monocyte_chemoattractant_protein-1 expression in human mesangial cells : role for JNK/AP -1 pathway .
21729805	0	Bone_morphogenetic_protein-binding_peptide	0,42	bone_morphogenetic_protein-2	98,126	Bone morphogenetic protein-binding peptide	bone morphogenetic protein-2	25907	650	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Bone_morphogenetic_protein-binding_peptide reduces the inflammatory response to recombinant human bone_morphogenetic_protein-2 and recombinant human bone_morphogenetic_protein-7 in a rodent model of soft-tissue inflammation .
10446267	0	Bone_morphogenetic_protein_1	0,28	chordin	103,110	Bone morphogenetic protein 1	chordin	399093(Tax:8355)	398045(Tax:8355)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Bone_morphogenetic_protein_1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading chordin , a BMP4 antagonist .
9069167	0	Bone_morphogenetic_protein_2	0,28	BMP-3	46,51	Bone morphogenetic protein 2	BMP-3	29373(Tax:10116)	25667(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Bone_morphogenetic_protein_2 -LRB- BMP-2 -RRB- enhances BMP-3 , BMP-4 , and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts .
19211807	0	Bone_morphogenetic_protein_2	0,28	BMPR1A	41,47	Bone morphogenetic protein 2	BMPR1A	12156(Tax:10090)	12166(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Bone_morphogenetic_protein_2 signals via BMPR1A to regulate murine follicle-stimulating_hormone_beta_subunit transcription .
24601881	0	Bone_morphogenetic_protein_2	0,28	BMP_type_1A_receptor	79,99	Bone morphogenetic protein 2	BMP type 1A receptor	12156(Tax:10090)	12166(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Bone_morphogenetic_protein_2 stimulates noncanonical SMAD2/3 signaling via the BMP_type_1A_receptor in gonadotrope-like cells : implications for FSH synthesis .
17215250	0	Bone_morphogenetic_protein_2	0,28	Runx2	107,112	Bone morphogenetic protein 2	Runx2	650	860	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Bone_morphogenetic_protein_2 activates Smad6 gene transcription through bone-specific transcription factor Runx2 .
24601881	0	Bone_morphogenetic_protein_2	0,28	SMAD2/3	53,60	Bone morphogenetic protein 2	SMAD2/3	12156(Tax:10090)	17126;17127	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Bone_morphogenetic_protein_2 stimulates noncanonical SMAD2/3 signaling via the BMP_type_1A_receptor in gonadotrope-like cells : implications for FSH synthesis .
17215250	0	Bone_morphogenetic_protein_2	0,28	Smad6	39,44	Bone morphogenetic protein 2	Smad6	650	4091	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Bone_morphogenetic_protein_2 activates Smad6 gene transcription through bone-specific transcription factor Runx2 .
12489168	0	Bone_morphogenetic_protein_2	0,28	cementum_attachment_protein	55,82	Bone morphogenetic protein 2	cementum attachment protein	650	9200	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Bone_morphogenetic_protein_2 induces the expression of cementum_attachment_protein in human periodontal ligament clones .
12162497	0	Bone_morphogenetic_protein_2	0,28	cyclo-oxygenase_2	37,54	Bone morphogenetic protein 2	cyclo-oxygenase 2	12156(Tax:10090)	19225(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Bone_morphogenetic_protein_2 induces cyclo-oxygenase_2 in osteoblasts via a Cbfal binding site : role in effects of bone_morphogenetic_protein_2 in vitro and in vivo .
13678785	0	Bone_morphogenetic_protein_2	0,28	placental_growth_factor	37,60	Bone morphogenetic protein 2	placental growth factor	650	5228	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Bone_morphogenetic_protein_2 induces placental_growth_factor in mesenchymal stem cells .
21628466	0	Bone_morphogenetic_protein_3	0,28	insulin	38,45	Bone morphogenetic protein 3	insulin	110075(Tax:10090)	3630	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	Bone_morphogenetic_protein_3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes_of_the_young mutation .
19031438	0	Bone_morphogenetic_protein_4	0,28	TGF-beta2	38,47	Bone morphogenetic protein 4	TGF-beta2	652	7042	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Bone_morphogenetic_protein_4 inhibits TGF-beta2 stimulation of extracellular matrix proteins in optic nerve head cells : role of gremlin in ECM modulation .
17897310	0	Bone_morphogenetic_protein_4	0,28	c-Kit	39,44	Bone morphogenetic protein 4	c-Kit	12159(Tax:10090)	16590(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Bone_morphogenetic_protein_4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro .
22158624	0	Bone_morphogenetic_protein_4	0,28	microRNA-21	89,100	Bone morphogenetic protein 4	microRNA-21	652	406991	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Bone_morphogenetic_protein_4 promotes vascular smooth muscle contractility by activating microRNA-21 -LRB- miR-21 -RRB- , which down-regulates expression of family of dedicator of cytokinesis -LRB- DOCK -RRB- proteins .
22943534	0	Bone_morphogenetic_protein_4	0,28	vascular_endothelial_growth_factor	54,88	Bone morphogenetic protein 4	vascular endothelial growth factor	407216(Tax:9913)	281572(Tax:9913)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Bone_morphogenetic_protein_4 -LRB- BMP-4 -RRB- and BMP-7 induce vascular_endothelial_growth_factor expression in bovine granulosa cells .
17522432	0	Bone_morphogenetic_protein_7	0,28	BMP7	30,34	Bone morphogenetic protein 7	BMP7	655	655	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Bone_morphogenetic_protein_7 -LRB- BMP7 -RRB- expression is a potential novel prognostic marker for recurrence in patients with primary melanoma .
24023033	0	Bone_morphogenetic_protein_7	0,28	VEGF	75,79	Bone morphogenetic protein 7	VEGF	655	7422	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Bone_morphogenetic_protein_7 increased vascular_endothelial_growth_factor -LRB- VEGF -RRB- - a expression in human granulosa cells and VEGF receptor expression in endothelial cells .
24649049	0	Bone_morphogenetic_protein_7	0,28	nestin	59,65	Bone morphogenetic protein 7	nestin	85272(Tax:10116)	25491(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Bone_morphogenetic_protein_7 upregulates the expression of nestin and glial_fibrillary_acidic_protein in rats with cerebral_ischemia-reperfusion injury .
12135884	0	Bone_morphogenetic_protein_receptor_type_II	0,43	growth_differentiation_factor-9	62,93	Bone morphogenetic protein receptor type II	growth differentiation factor-9	659	2661	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Bone_morphogenetic_protein_receptor_type_II is a receptor for growth_differentiation_factor-9 .
9878060	0	Boo	0,3	Apaf-1	62,68	Boo	Apaf-1	10017	317	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Boo , a novel negative regulator of cell death , interacts with Apaf-1 .
11522832	0	Bop1	37,41	ERB1	0,4	Bop1	ERB1	23246	855068(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	ERB1 , the yeast homolog of mammalian Bop1 , is an essential gene required for maturation of the 25S and 5.8 S ribosomal RNAs .
16890155	0	Bora	71,75	Aurora-A	33,41	Bora	Aurora-A	40031(Tax:7227)	41446(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|activation activation|nmod|END_ENTITY	Mitotic activation of the kinase Aurora-A requires its binding partner Bora .
23592782	0	Bora	135,139	Aurora_A	117,125	Bora	Aurora A	79866	6790	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Ataxia_telangiectasia-mutated - _ and_Rad3-related_protein regulates the DNA damage-induced G2/M checkpoint through the Aurora_A cofactor Bora protein .
25753036	0	Bora	27,31	Cdk1	0,4	Bora	Cdk1	79866	176374(Tax:6239)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cdk1 phosphorylates SPAT-1 / Bora to trigger PLK-1 activation and drive mitotic entry in C. _ elegans embryos .
18378770	0	Bora	45,49	Plk1	0,4	Bora	Plk1	79866	5347	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Plk1 - and beta-TrCP-dependent degradation of Bora controls mitotic progression .
18566290	0	Bora	0,4	Plk1	63,67	Bora	Plk1	79866	5347	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Bora and the kinase Aurora_a cooperatively activate the kinase Plk1 and control mitotic entry .
20823068	0	Bora	7,11	Polo-like_kinase_1	22,40	Bora	Polo-like kinase 1	79866	5347	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	SPAT-1 / Bora acts with Polo-like_kinase_1 to regulate PAR polarity and cell cycle progression .
18243099	0	Borealin	20,28	Mps1	0,4	Borealin	Mps1	55143	7272	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Mps1 phosphorylates Borealin to control Aurora_B activity and chromosome alignment .
18946085	0	Borealin	82,90	RanBP2	0,6	Borealin	RanBP2	55143	5903	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin .
9243499	0	Bos1p	28,33	Bet1p	0,5	Bos1p	Bet1p	850767(Tax:4932)	854813(Tax:4932)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Bet1p activates the v-SNARE Bos1p .
3257976	0	Bp50	67,71	CDw40	60,65	Bp50	CDw40	474207	958	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Resting B lymphocytes can be triggered directly through the CDw40 -LRB- Bp50 -RRB- antigen .
12142541	0	Bphs	18,22	histamine_receptor_H1	56,77	Bphs	histamine receptor H1	15465(Tax:10090)	15465(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Bphs , an autoimmune_disease locus , as histamine_receptor_H1 .
11804777	0	Brachyury	22,31	XSIP1	70,75	Brachyury	XSIP1	399275(Tax:8355)	100049718(Tax:8355)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1 .
10769246	0	Brachyury	30,39	Xwnt11	0,6	Brachyury	Xwnt11	399275(Tax:8355)	446915(Tax:8355)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Xwnt11 is a target of Xenopus Brachyury : regulation of gastrulation movements via Dishevelled , but not through the canonical Wnt pathway .
1334347	0	Bradykinin	0,10	B2-receptor	105,116	Bradykinin	B2-receptor	3827	624	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Bradykinin suppresses endothelin-induced contraction of coronary , renal and femoral arteries through its B2-receptor on the endothelium .
1659421	0	Bradykinin	0,10	B2-receptor	84,95	Bradykinin	B2-receptor	3827	624	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Bradykinin suppresses endothelin-induced contraction of coronary artery through its B2-receptor on the endothelium .
16337452	0	Bradykinin	0,10	B2_receptor	86,97	Bradykinin	B2 receptor	3827	624	Gene	Gene	differentiates|nsubj|START_ENTITY differentiates|nmod|phenotype phenotype|nmod|END_ENTITY	Bradykinin differentiates human lung fibroblasts to a myofibroblast phenotype via the B2_receptor .
24833299	0	Bradykinin	0,10	B2_receptor	47,58	Bradykinin	B2 receptor	3827	624	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|activation activation|amod|END_ENTITY	Bradykinin induces NO and PGF2a production via B2_receptor activation from cultured porcine basilar arterial endothelial cells .
9657256	0	Bradykinin	0,10	B2_receptor	100,111	Bradykinin	B2 receptor	3827	624	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|line line|nmod|subtype subtype|amod|END_ENTITY	Bradykinin increases intracellular calcium levels in a human bronchial epithelial cell line via the B2_receptor subtype .
12532104	0	Bradykinin	0,10	CXCR1	75,80	Bradykinin	CXCR1	3827	3577	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic_rhinitis .
11028659	0	Bradykinin	0,10	ERK	81,84	Bradykinin	ERK	3827	5594	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK - and p38_MAPK-dependent mechanisms .
11028659	0	Bradykinin	0,10	IL-6	22,26	Bradykinin	IL-6	3827	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK - and p38_MAPK-dependent mechanisms .
25109623	0	Bradykinin	0,10	IL-6	22,26	Bradykinin	IL-6	3827	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Bradykinin stimulates IL-6 production and cell invasion in colorectal_cancer cells .
12169581	0	Bradykinin	0,10	IL-8	21,25	Bradykinin	IL-8	3827	3576	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|generation generation|compound|END_ENTITY	Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids .
15664665	0	Bradykinin	0,10	IL-8	23,27	Bradykinin	IL-8	3827	3576	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|alpha alpha|nsubj|production production|compound|END_ENTITY	Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha .
9725250	0	Bradykinin	0,10	IL-8	22,26	Bradykinin	IL-8	3827	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells : role of cyclooxygenase products .
11345366	0	Bradykinin	0,10	angiotensin-converting_enzyme	108,137	Bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|dep|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Bradykinin stimulates the release of tissue_plasminogen_activator in human coronary circulation : effects of angiotensin-converting_enzyme inhibitors .
11684627	0	Bradykinin	0,10	angiotensin-converting_enzyme	61,90	Bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|effects effects|nmod|inhibition inhibition|amod|END_ENTITY	Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting_enzyme inhibition in patients with heart_failure .
12019275	0	Bradykinin	0,10	angiotensin-converting_enzyme	72,101	Bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	improves|nsubj|START_ENTITY improves|dep|ventricular ventricular|nmod|inhibition inhibition|amod|END_ENTITY	Bradykinin improves left ventricular diastolic function under long-term angiotensin-converting_enzyme inhibition in heart_failure .
15105283	0	Bradykinin	0,10	angiotensin-converting_enzyme	70,99	Bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|effects effects|nmod|inhibition inhibition|amod|END_ENTITY	Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting_enzyme inhibition in patients with heart_failure .
12028132	0	Bradykinin	0,10	angiotensin_converting_enzyme	30,59	Bradykinin	angiotensin converting enzyme	3827	1636	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|modulation modulation|amod|END_ENTITY	Bradykinin is not involved in angiotensin_converting_enzyme modulation of ovarian steroidogenesis and prostaglandin production in frog Rana esculenta .
2153061	0	Bradykinin	0,10	angiotensin_converting_enzyme	54,83	Bradykinin	angiotensin converting enzyme	478666(Tax:9615)	610668(Tax:9615)	Gene	Gene	contribution|compound|START_ENTITY contribution|nmod|inhibitor inhibitor|amod|END_ENTITY	Bradykinin contribution to renal_blood_flow effect of angiotensin_converting_enzyme inhibitor in the conscious sodium-restricted dog .
11352510	0	Bradykinin	0,10	cyclooxygenase-2	27,43	Bradykinin	cyclooxygenase-2	3827	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bradykinin induces a rapid cyclooxygenase-2 mRNA expression via Ca2 + mobilization in human gingival fibroblasts primed with interleukin-1_beta .
15640399	0	Bradykinin	0,10	endothelial_nitric-oxide_synthase	66,99	Bradykinin	endothelial nitric-oxide synthase	3827	4846	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Bradykinin down-regulates , whereas arginine analogs up-regulates , endothelial_nitric-oxide_synthase expression in coronary endothelial cells .
10501190	0	Bradykinin	0,10	interleukin-6	19,32	Bradykinin	interleukin-6	3827	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear_factor-kappaB .
12594059	0	Bradykinin	0,10	interleukin-6	19,32	Bradykinin	interleukin-6	3827	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Bradykinin induces interleukin-6 production in human airway_smooth_muscle cells : modulation by Th2 cytokines and dexamethasone .
1932373	0	Bradykinin	0,10	interleukin-6	19,32	Bradykinin	interleukin-6	3827	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Bradykinin induces interleukin-6 and synergizes with interleukin-1 .
9141588	0	Bradykinin	0,10	interleukin-6	22,35	Bradykinin	interleukin-6	3827	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Bradykinin stimulates interleukin-6 and interleukin-8 secretion of human decidua derived cells .
9893038	0	Bradykinin	0,10	interleukin-8	22,35	Bradykinin	interleukin-8	3827	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Bradykinin stimulates interleukin-8 production by human lung fibroblasts .
9505142	0	Bradykinin	0,10	interleukin_6	38,51	Bradykinin	interleukin 6	3827	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Bradykinin synergistically stimulates interleukin_6 production in human gingival fibroblasts challenged with interleukin 1 or tumour_necrosis factor alpha .
23376352	0	Bradykinin	0,10	nerve_growth_factor	33,52	Bradykinin	nerve growth factor	3827	4803	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|compound|END_ENTITY	Bradykinin modulates spontaneous nerve_growth_factor production and stretch-induced ATP release in human urothelium .
10501190	0	Bradykinin	0,10	nuclear_factor-kappaB	80,101	Bradykinin	nuclear factor-kappaB	3827	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear_factor-kappaB .
9600070	0	Bradykinin	0,10	phospholipase_C_gamma_1	93,116	Bradykinin	phospholipase C gamma 1	3827	5335	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2_receptor association of phospholipase_C_gamma_1 in vascular endothelial cells .
11419696	0	Bradykinin	0,10	phospholipase_D	60,75	Bradykinin	phospholipase D	3827	2822	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Bradykinin induces protein kinase C-dependent activation of phospholipase_D in A-431 cells .
10373228	0	Bradykinin	0,10	tissue_plasminogen_activator	22,50	Bradykinin	tissue plasminogen activator	3827	100128998	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Bradykinin stimulates tissue_plasminogen_activator release in human vasculature .
11056091	0	Bradykinin	0,10	tissue_plasminogen_activator	22,50	Bradykinin	tissue plasminogen activator	3827	100128998	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Bradykinin stimulates tissue_plasminogen_activator release from human forearm vasculature through B -LRB- 2 -RRB- receptor-dependent , NO synthase-independent , and cyclooxygenase-independent pathway .
11345366	0	Bradykinin	0,10	tissue_plasminogen_activator	37,65	Bradykinin	tissue plasminogen activator	3827	100128998	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Bradykinin stimulates the release of tissue_plasminogen_activator in human coronary circulation : effects of angiotensin-converting_enzyme inhibitors .
24225154	0	Bradykinin	0,10	vascular_endothelial_growth_factor	20,54	Bradykinin	vascular endothelial growth factor	3827	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Bradykinin promotes vascular_endothelial_growth_factor expression and increases angiogenesis in human prostate_cancer cells .
11408528	0	Bradykinin_B1_receptor	0,22	interleukin-1beta	40,57	Bradykinin B1 receptor	interleukin-1beta	623	3553	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|agonist agonist|amod|END_ENTITY	Bradykinin_B1_receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts .
26477313	0	Braf	14,18	p53	96,99	Braf	p53	109880(Tax:10090)	22059(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	TSH overcomes Braf -LRB- V600E -RRB- - induced senescence to promote tumor progression via downregulation of p53 expression in papillary_thyroid_cancer .
15454538	0	Brahma	76,82	SNR1	0,4	Brahma	SNR1	39744(Tax:7227)	40657(Tax:7227)	Gene	Gene	functions|nmod|START_ENTITY mediates|dobj|functions mediates|nsubj|END_ENTITY	SNR1 -LRB- INI1/SNF5 -RRB- mediates important cell growth functions of the Drosophila Brahma -LRB- SWI/SNF -RRB- chromatin remodeling complex .
15454538	0	Brahma	76,82	SWI/SNF	84,91	Brahma	SWI/SNF	39744(Tax:7227)	31120;31442	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	SNR1 -LRB- INI1/SNF5 -RRB- mediates important cell growth functions of the Drosophila Brahma -LRB- SWI/SNF -RRB- chromatin remodeling complex .
21640793	0	Brain-Derived_Neurotrophic_Factor	45,78	BDNF	80,84	Brain-Derived Neurotrophic Factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between Val66Met polymorphism of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- gene and a deficiency_of_colour_vision in alcohol-dependent male patients .
25634725	0	Brain-Derived_Neurotrophic_Factor	42,75	BDNF	77,81	Brain-Derived Neurotrophic Factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Differential Expression and Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- mRNA Isoforms in Brain Cells from Mecp2 -LRB- 308/y -RRB- Mouse Model .
26039045	0	Brain-Derived_Neurotrophic_Factor	82,115	Eps8	12,16	Brain-Derived Neurotrophic Factor	Eps8	627	2059	Gene	Gene	Neurons|nmod|START_ENTITY Filopodia|nmod|Neurons Filopodia|compound|END_ENTITY	Correction : Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- .
25579386	0	Brain-Derived_Neurotrophic_Factor	30,63	MeCP2	104,109	Brain-Derived Neurotrophic Factor	MeCP2	627	4204	Gene	Gene	START_ENTITY|nmod|Protein Protein|appos|END_ENTITY	Transcriptional Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- by Methyl_CpG Binding Protein 2 -LRB- MeCP2 -RRB- : a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple_Sclerosis -LRB- MS -RRB- .
19281964	0	Brain-Derived_Neurotrophic_Factor	1,34	neurotrophin	56,68	Brain-Derived Neurotrophic Factor	neurotrophin	627	627	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	-LSB- Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- : role of this neurotrophin in cardiovascular physiopathology -RSB- .
12142916	0	Brain-derived_Neurotrophic_Factor	14,47	BDNF	49,53	Brain-derived Neurotrophic Factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Expression of Brain-derived_Neurotrophic_Factor -LRB- BDNF -RRB- Gene in Rat Myoblast Cells .
26849417	0	Brain-derived_Neurotrophic_Factor	17,50	BDNF	52,56	Brain-derived Neurotrophic Factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Transfer|nmod|START_ENTITY Transfer|appos|END_ENTITY	Gene Transfer of Brain-derived_Neurotrophic_Factor -LRB- BDNF -RRB- Prevents Neurodegeneration Triggered by FXN Deficiency .
12426055	0	Brain-derived_neurotrophic_factor	0,33	BDNF	35,39	Brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus .
17012654	0	Brain-derived_neurotrophic_factor	0,33	BDNF	35,39	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and rapid-cycling bipolar_disorder : family-based association study .
19236730	0	Brain-derived_neurotrophic_factor	0,33	BDNF	36,40	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene : no major impact on antidepressant treatment response .
21616543	0	Brain-derived_neurotrophic_factor	0,33	BDNF	35,39	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- plasma levels in drug-na ve OCD patients are lower than those in healthy people , but are not lower than those in drug-treated OCD patients .
21695421	0	Brain-derived_neurotrophic_factor	0,33	BDNF	35,39	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene : a gender-specific role in cognitive function during normal cognitive_aging of the MEMO-Study ?
21924942	0	Brain-derived_neurotrophic_factor	0,33	BDNF	35,39	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- genetic polymorphism greatly increases risk of leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- for Parkinson 's _ disease .
23933054	0	Brain-derived_neurotrophic_factor	18,51	BDNF	53,57	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Changes in plasma Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels induced by methylphenidate in children with Attention_deficit-hyperactivity_disorder -LRB- ADHD -RRB- .
25001952	0	Brain-derived_neurotrophic_factor	0,33	BDNF	35,39	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism affects sympathetic tone in a gender-specific way .
25438605	0	Brain-derived_neurotrophic_factor	1,34	BDNF	41,45	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- polymorphism among Moscow citizens -RSB- .
25508136	0	Brain-derived_neurotrophic_factor	1,34	BDNF	41,45	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- polymorphism among Moscow citizens -RSB- .
25640836	0	Brain-derived_neurotrophic_factor	0,33	BDNF	35,39	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes .
20731656	0	Brain-derived_neurotrophic_factor	0,33	Bcl-xL	43,49	Brain-derived neurotrophic factor	Bcl-xL	24225(Tax:10116)	24888(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor enhances Bcl-xL expression through protein kinase casein kinase 2-activated and nuclear_factor_kappa_B-mediated pathway in rat hippocampus .
22035109	0	Brain-derived_neurotrophic_factor	0,33	CREB	39,43	Brain-derived neurotrophic factor	CREB	24225(Tax:10116)	81646(Tax:10116)	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Brain-derived_neurotrophic_factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons .
9200733	0	Brain-derived_neurotrophic_factor	0,33	DARPP-32	62,70	Brain-derived neurotrophic factor	DARPP-32	12064(Tax:10090)	19049(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|maturation maturation|nmod|phenotype phenotype|compound|END_ENTITY	Brain-derived_neurotrophic_factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons : studies in vivo and in vitro .
17003042	0	Brain-derived_neurotrophic_factor	0,33	ERK5	44,48	Brain-derived neurotrophic factor	ERK5	24225(Tax:10116)	114509(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Brain-derived_neurotrophic_factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade .
26876757	0	Brain-derived_neurotrophic_factor	0,33	Etv4	194,198	Brain-derived neurotrophic factor	Etv4	627	2118	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor promotes vesicular_glutamate_transporter_3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5 .
9089204	0	Brain-derived_neurotrophic_factor	0,33	GAP-43	44,50	Brain-derived neurotrophic factor	GAP-43	24225(Tax:10116)	29423(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Brain-derived_neurotrophic_factor modulates GAP-43 but not T alpha1 expression in injured retinal_ganglion cells of adult rats .
22261313	0	Brain-derived_neurotrophic_factor	0,33	MnSOD	58,63	Brain-derived neurotrophic factor	MnSOD	627	6648	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Brain-derived_neurotrophic_factor increases expression of MnSOD in human circulating angiogenic cells .
12954875	0	Brain-derived_neurotrophic_factor	0,33	NFAT	48,52	Brain-derived neurotrophic factor	NFAT	24225(Tax:10116)	307820(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor activation of NFAT -LRB- nuclear_factor_of_activated_T-cells -RRB- - dependent transcription : a role for the transcription factor NFATc4 in neurotrophin-mediated gene expression .
10381539	0	Brain-derived_neurotrophic_factor	0,33	NR2B	124,128	Brain-derived neurotrophic factor	NR2B	24225(Tax:10116)	24410(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Brain-derived_neurotrophic_factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density .
12074588	0	Brain-derived_neurotrophic_factor	0,33	TrkB	92,96	Brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|interaction interaction|nmod|protein protein|nmod|receptor receptor|compound|END_ENTITY	Brain-derived_neurotrophic_factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor .
12438277	0	Brain-derived_neurotrophic_factor	0,33	TrkB	48,52	Brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol_3 ' - kinase pathway .
12719654	0	Brain-derived_neurotrophic_factor	0,33	TrkB	34,38	Brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	START_ENTITY|appos|signaling signaling|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor / TrkB signaling in memory processes .
15140649	0	Brain-derived_neurotrophic_factor	0,33	TrkB	42,46	Brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|protein protein|compound|END_ENTITY	Brain-derived_neurotrophic_factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats .
15581399	0	Brain-derived_neurotrophic_factor	0,33	TrkB	48,52	Brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB protects neurons from HIV-1 / gp120-induced cell death .
16618748	0	Brain-derived_neurotrophic_factor	0,33	TrkB	48,52	Brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
19686240	0	Brain-derived_neurotrophic_factor	0,33	TrkB	46,50	Brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|END_ENTITY	Brain-derived_neurotrophic_factor facilitates TrkB down-regulation and neuronal_injury after status_epilepticus in the rat hippocampus .
23640807	0	Brain-derived_neurotrophic_factor	0,33	TrkB	34,38	Brain-derived neurotrophic factor	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Brain-derived_neurotrophic_factor / TrkB signaling regulates daily astroglial plasticity in the suprachiasmatic nucleus : electron-microscopic evidence in mouse .
25043764	0	Brain-derived_neurotrophic_factor	0,33	TrkB	66,70	Brain-derived neurotrophic factor	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	zinc|amod|START_ENTITY promotes|nsubj|zinc promotes|dobj|activation activation|compound|END_ENTITY	Brain-derived_neurotrophic_factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo .
9303531	0	Brain-derived_neurotrophic_factor	0,33	TrkB	58,62	Brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	START_ENTITY|appos|localized localized|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor / neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina .
23508111	0	Brain-derived_neurotrophic_factor	0,33	c-Fos	121,126	Brain-derived neurotrophic factor	c-Fos	24225(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|neurons neurons|nmod|END_ENTITY	Brain-derived_neurotrophic_factor induces matrix_metalloproteinase_9 expression in neurons via the serum_response_factor / c-Fos pathway .
18055129	0	Brain-derived_neurotrophic_factor	0,33	extracellular_signal-regulated_kinase	146,183	Brain-derived neurotrophic factor	extracellular signal-regulated kinase	24225(Tax:10116)	24338(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY autonomous|nsubj|activation autonomous|nmod|pathway pathway|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of extracellular_signal-regulated_kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular_signal-regulated_kinase shutoff pathway .
18055129	0	Brain-derived_neurotrophic_factor	0,33	extracellular_signal-regulated_kinase	48,85	Brain-derived neurotrophic factor	extracellular signal-regulated kinase	24225(Tax:10116)	24338(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor activation of extracellular_signal-regulated_kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular_signal-regulated_kinase shutoff pathway .
10196222	0	Brain-derived_neurotrophic_factor	0,33	fibroblast_growth_factor_receptor_substrate_2	61,106	Brain-derived neurotrophic factor	fibroblast growth factor receptor substrate 2	627	10818	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor induces phosphorylation of fibroblast_growth_factor_receptor_substrate_2 .
24747341	0	Brain-derived_neurotrophic_factor	0,33	gephyrin	43,51	Brain-derived neurotrophic factor	gephyrin	24225(Tax:10116)	64845(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor promotes gephyrin protein expression and GABAA receptor clustering in immature cultured hippocampal cells .
20089917	0	Brain-derived_neurotrophic_factor	0,33	m-calpain	80,89	Brain-derived neurotrophic factor	m-calpain	627	824	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Brain-derived_neurotrophic_factor and epidermal_growth_factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation .
23508111	0	Brain-derived_neurotrophic_factor	0,33	matrix_metalloproteinase_9	42,68	Brain-derived neurotrophic factor	matrix metalloproteinase 9	24225(Tax:10116)	81687(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor induces matrix_metalloproteinase_9 expression in neurons via the serum_response_factor / c-Fos pathway .
22081998	0	Brain-derived_neurotrophic_factor	0,33	miR-206	93,100	Brain-derived neurotrophic factor	miR-206	627	406989	Gene	Gene	expression|compound|START_ENTITY repressed|nsubj|expression repressed|advcl|END_ENTITY	Brain-derived_neurotrophic_factor expression is repressed during myogenic differentiation by miR-206 .
17630987	0	Brain-derived_neurotrophic_factor	0,33	myocyte-enhancer_factor_2C	97,123	Brain-derived neurotrophic factor	myocyte-enhancer factor 2C	627	4208	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	Brain-derived_neurotrophic_factor stimulates the transcriptional and neuroprotective activity of myocyte-enhancer_factor_2C through an ERK1/2-RSK 2 signaling cascade .
8025254	0	Brain-derived_neurotrophic_factor	0,33	neuropeptide	52,64	Brain-derived neurotrophic factor	neuropeptide	24225(Tax:10116)	379044(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Brain-derived_neurotrophic_factor enhances striatal neuropeptide expression in both the intact and the dopamine-depleted rat striatum .
10338311	0	Brain-derived_neurotrophic_factor	0,33	neuropeptide_Y	182,196	Brain-derived neurotrophic factor	neuropeptide Y	24225(Tax:10116)	24604(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|dep|evolution evolution|nmod|changes changes|acl|END_ENTITY	Brain-derived_neurotrophic_factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions : temporal evolution of changes as compared to neuropeptide_Y .
8288635	0	Brain-derived_neurotrophic_factor	0,33	neurotrophin-3	44,58	Brain-derived neurotrophic factor	neurotrophin-3	24225(Tax:10116)	81737(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor increases neurotrophin-3 expression in cerebellar granule neurons .
18752299	0	Brain-derived_neurotrophic_factor	0,33	trkB	117,121	Brain-derived neurotrophic factor	trkB	627	4915	Gene	Gene	effects|amod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Brain-derived_neurotrophic_factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway .
24801982	0	Brain-derived_neurotrophic_factor	0,33	tropomyosin-related_kinase_B	49,77	Brain-derived neurotrophic factor	tropomyosin-related kinase B	627	4915	Gene	Gene	START_ENTITY|dep|signaling signaling|compound|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced tropomyosin-related_kinase_B -LRB- Trk_B -RRB- signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal_cancer .
21239439	0	Brain-derived_neurotrophic_factor	0,33	tyrosine_kinase_B	34,51	Brain-derived neurotrophic factor	tyrosine kinase B	627	4915	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Brain-derived_neurotrophic_factor / tyrosine_kinase_B signaling regulates human trophoblast growth in an in vivo animal model of ectopic pregnancy .
16618748	0	Brain-derived_neurotrophic_factor	0,33	vascular_endothelial_growth_factor	61,95	Brain-derived neurotrophic factor	vascular endothelial growth factor	627	7422	Gene	Gene	activation|amod|START_ENTITY induces|nsubj|activation induces|dobj|expression expression|compound|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
25150213	0	Brain-derived_neurotrophic_factor	0,33	vascular_endothelial_growth_factor	44,78	Brain-derived neurotrophic factor	vascular endothelial growth factor	627	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Brain-derived_neurotrophic_factor increases vascular_endothelial_growth_factor expression and enhances angiogenesis in human chondrosarcoma cells .
14574682	0	Brain-derived_neurotrophic_factor	0,33	vasoactive_intestinal_polypeptide	58,91	Brain-derived neurotrophic factor	vasoactive intestinal polypeptide	12064(Tax:10090)	22353(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Brain-derived_neurotrophic_factor regulates expression of vasoactive_intestinal_polypeptide in retinal amacrine cells .
26876757	0	Brain-derived_neurotrophic_factor	0,33	vesicular_glutamate_transporter_3	43,76	Brain-derived neurotrophic factor	vesicular glutamate transporter 3	627	246213	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor promotes vesicular_glutamate_transporter_3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5 .
18253057	0	Brain-derived_neurotropic_factor	0,32	TrkB	33,37	Brain-derived neurotropic factor	TrkB	627	4915	Gene	Gene	START_ENTITY|appos|signaling signaling|nsubj|END_ENTITY	Brain-derived_neurotropic_factor / TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia .
22798068	0	Brain-selective_kinase_2	0,24	BRSK2	26,31	Brain-selective kinase 2	BRSK2	75770(Tax:10090)	75770(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Brain-selective_kinase_2 -LRB- BRSK2 -RRB- phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic b-cells .
22798068	0	Brain-selective_kinase_2	0,24	PCTAIRE1	52,60	Brain-selective kinase 2	PCTAIRE1	75770(Tax:10090)	18555(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Brain-selective_kinase_2 -LRB- BRSK2 -RRB- phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic b-cells .
24112874	0	Brain_Derived_Neurotrophic_Factor	0,33	BDNF	35,39	Brain Derived Neurotrophic Factor	BDNF	627	627	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Brain_Derived_Neurotrophic_Factor -LRB- BDNF -RRB- levels as a possible predictor of psychopathology in healthy twins at high and low risk for affective_disorder .
25409418	0	Brain_Natriuretic_Peptide	25,50	BNP	52,55	Brain Natriuretic Peptide	BNP	4879	4879	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	Relationship Between the Brain_Natriuretic_Peptide -LRB- BNP -RRB- Level and Remission of Diabetic_Nephropathy with Microalbuminuria : A 3-Year Follow-Up Study .
14678827	0	Brain_Specific_homeoboX	31,54	Bsx	0,3	Brain Specific homeoboX	Bsx	244813(Tax:10090)	244813(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Bsx , an evolutionary conserved Brain_Specific_homeoboX gene expressed in the septum , epiphysis , mammillary bodies and arcuate nucleus .
22194877	0	Brain_derived_neurotrophic_factor	0,33	BDNF	35,39	Brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Brain_derived_neurotrophic_factor -LRB- BDNF -RRB- expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding .
23793276	0	Brain_derived_neurotrophic_factor	0,33	BDNF	35,39	Brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Brain_derived_neurotrophic_factor -LRB- BDNF -RRB- levels in depressed women treated with open-label escitalopram .
25132151	0	Brain_derived_neurotrophic_factor	0,33	BDNF	40,44	Brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Brain_derived_neurotrophic_factor gene -LRB- BDNF -RRB- and personality traits : The modifying effect of season of birth and sex .
25451258	0	Brain_derived_neurotrophic_factor	0,33	GSK3b	96,101	Brain derived neurotrophic factor	GSK3b	627	2932	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	Brain_derived_neurotrophic_factor is involved in the regulation of glycogen_synthase_kinase_3b -LRB- GSK3b -RRB- signalling .
8917547	0	Brca1	37,42	Brca2	0,5	Brca1	Brca2	672	675	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells .
9133444	0	Brca1	51,56	Brca2	28,33	Brca1	Brca2	672	675	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|expression expression|nmod|END_ENTITY	Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues .
15485917	0	Brca1	139,144	Chk2	110,114	Brca1	Chk2	12189(Tax:10090)	50883(Tax:10090)	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Uterus_hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1 .
20818429	0	Brca1	16,21	CtBP1	67,72	Brca1	CtBP1	672	1487	Gene	Gene	transcriptional|nsubj|START_ENTITY transcriptional|nmod|END_ENTITY	Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1 .
21681822	0	Brca1	35,40	CtBP1	59,64	Brca1	CtBP1	672	1487	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast_cancer .
18703154	0	Brca1	27,32	p14ARF	15,21	Brca1	p14ARF	672	1029	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of p14ARF with Brca1 in cancer cell lines and primary breast_cancer .
8917547	0	Brca2	0,5	Brca1	37,42	Brca2	Brca1	675	672	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells .
9133444	0	Brca2	28,33	Brca1	51,56	Brca2	Brca1	675	672	Gene	Gene	expression|nmod|START_ENTITY colocalizes|nsubj|expression colocalizes|nmod|END_ENTITY	Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues .
15657438	0	Brca2	19,24	Rad51	146,151	Brca2	Rad51	374139(Tax:9031)	396086(Tax:9031)	Gene	Gene	truncation|amod|START_ENTITY effects|nmod|truncation support|nsubj|effects support|dobj|role role|nmod|paralogs paralogs|amod|END_ENTITY	Similar effects of Brca2 truncation and Rad51 paralog_deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination .
19540122	0	Brca2	25,30	Rad51	56,61	Brca2	Rad51	675	5888	Gene	Gene	terminus|nmod|START_ENTITY links|nsubj|terminus links|dobj|disassembly disassembly|nmod|complexes complexes|amod|END_ENTITY	The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry .
9126738	0	Brca2	85,90	Rad51	63,68	Brca2	Rad51	12190(Tax:10090)	19361(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY mediated|xcomp|lacking mediated|nmod|END_ENTITY	Embryonic_lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 .
24695857	0	Brd2	25,29	Pleiotrophin	0,12	Brd2	Pleiotrophin	6046	5764	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Pleiotrophin antagonizes Brd2 during neuronal differentiation .
25242322	0	Brd4	32,36	BET	82,85	Brd4	BET	57261(Tax:10090)	227325(Tax:10090)	Gene	Gene	Silencing|nmod|START_ENTITY Identifies|nmod|Silencing Identifies|dobj|Toxicities Toxicities|nmod|Inhibition Inhibition|compound|END_ENTITY	Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition .
18922874	0	Brd4	68,72	EBNA1	4,9	Brd4	EBNA1	23476	17494214	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The EBNA1 protein of Epstein-Barr_virus functionally interacts with Brd4 .
15456879	0	Brd4	20,24	SPA-1	52,57	Brd4	SPA-1	23476	6494	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Bromodomain protein Brd4 binds to GTPase-activating SPA-1 , modulating its activity and subcellular localization .
19596781	0	Brd4	61,65	aurora_B	14,22	Brd4	aurora B	23476	9212	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of aurora_B expression by the bromodomain protein Brd4 .
20201073	0	Brd4_and_7SK	140,152	HEXIM1	153,159	Brd4 and 7SK	HEXIM1	23476	10614	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4_and_7SK / HEXIM1 regulatory complexes .
26465636	0	Breast_Cancer_Resistant_Protein	34,65	Peroxisome_Proliferator-Activated_Receptor_Alpha	76,124	Breast Cancer Resistant Protein	Peroxisome Proliferator-Activated Receptor Alpha	26357(Tax:10090)	19013(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	In Vivo and Ex Vivo Regulation of Breast_Cancer_Resistant_Protein -LRB- Bcrp -RRB- by Peroxisome_Proliferator-Activated_Receptor_Alpha -LRB- Ppara -RRB- at the Blood-Brain Barrier .
18514188	0	Breast_Cancer_Susceptibility_gene-1	98,133	BRCA1	135,140	Breast Cancer Susceptibility gene-1	BRCA1	672	672	Gene	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	Genistein induces apoptosis in ovarian_cancer cells via different molecular pathways depending on Breast_Cancer_Susceptibility_gene-1 -LRB- BRCA1 -RRB- status .
22711540	0	Breast_cancer_anti-estrogen_resistance_3	0,40	BCAR3	42,47	Breast cancer anti-estrogen resistance 3	BCAR3	8412	8412	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Breast_cancer_anti-estrogen_resistance_3 -LRB- BCAR3 -RRB- protein augments binding of the c-Src SH3 domain to Crk-associated_substrate _ -LRB- p130cas -RRB- .
17227585	0	Breast_cancer_metastasis_suppressor_1	0,37	osteopontin	55,66	Breast cancer metastasis suppressor 1	osteopontin	25855	6696	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Breast_cancer_metastasis_suppressor_1 -LRB- BRMS1 -RRB- inhibits osteopontin transcription by abrogating NF-kappaB activation .
12065415	0	Brg-1	20,25	Prohibitin	0,10	Brg-1	Prohibitin	6597	5245	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth .
20687958	0	Brg-1	0,5	SPARC	70,75	Brg-1	SPARC	6597	6678	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary_carcinoma cells via its interaction with transcription factor Sp1 .
18267097	0	Brg1	12,16	ADAMTS1	27,34	Brg1	ADAMTS1	6597	9510	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis .
11445556	0	Brg1	21,25	LKB1	0,4	Brg1	LKB1	6597	6794	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	LKB1 associates with Brg1 and is necessary for Brg1-induced growth_arrest .
27067865	0	Brg1	0,4	Olig2	24,29	Brg1	Olig2	20586(Tax:10090)	50913(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specification .
17043312	0	Brg1	8,12	POMC	63,67	Brg1	POMC	6597	5443	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing_disease .
20036644	0	Bri2	28,32	amyloid_precursor_protein	156,181	Bri2	amyloid precursor protein	9445	351	Gene	Gene	domain|nmod|START_ENTITY binds|nsubj|domain binds|nmod|processing processing|nmod|END_ENTITY	The extracellular domain of Bri2 -LRB- ITM2B -RRB- binds the ABri peptide -LRB- 1-23 -RRB- and amyloid_beta-peptide -LRB- Abeta1-40 -RRB- : Implications for Bri2 effects on processing of amyloid_precursor_protein and Abeta_aggregation .
15885879	0	Bridge-1	16,24	pancreas_duodenum_homeobox-1	65,93	Bridge-1	pancreas duodenum homeobox-1	161475(Tax:10116)	29535(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	The coactivator Bridge-1 increases transcriptional activation by pancreas_duodenum_homeobox-1 -LRB- PDX-1 -RRB- .
23530031	0	Bril	46,50	bone-restricted_IFITM-like	18,44	Bril	bone-restricted IFITM-like	387733	387733	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of the bone-restricted_IFITM-like -LRB- Bril -RRB- gene transcription by Sp and Gli family members and CpG methylation .
19270172	0	Brinker	37,44	dNAB	17,21	Brinker	dNAB	31665(Tax:7227)	3346237(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling .
15572663	0	Brk	0,3	rac1	14,18	Brk	rac1	5753	5879	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin .
15713637	0	Brn-1	33,38	Oct-6	69,74	Brn-1	Oct-6	18993(Tax:10090)	18991(Tax:10090)	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination .
15911144	0	Brn-2	38,43	Jab1	59,63	Brn-2	Jab1	5454	10987	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The neuronal POU transcription factor Brn-2 interacts with Jab1 , a gene involved in the onset of neurodegenerative_diseases .
10332029	0	Brn-2	90,95	PQBP-1	0,6	Brn-2	PQBP-1	18992(Tax:10090)	54633(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	PQBP-1 , a novel polyglutamine tract-binding protein , inhibits transcription activation by Brn-2 and affects cell survival .
18829533	0	Brn-2	0,5	microphthalmia-associated_transcription_factor	16,62	Brn-2	microphthalmia-associated transcription factor	5454	4286	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Brn-2 represses microphthalmia-associated_transcription_factor expression and marks a distinct subpopulation of microphthalmia-associated_transcription_factor-negative melanoma cells .
15532030	0	Brn-3a	16,22	p53	40,43	Brn-3a	p53	5457	7157	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis .
15042710	0	Brn-3b	64,70	Pou4f2	72,78	Brn-3b	Pou4f2	402816(Tax:7955)	402816(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of the POU domain transcription factor Brn-3b -LRB- Pou4f2 -RRB- in the lateral line and visual system of zebrafish .
15465029	0	Brn-3c	0,6	BDNF	26,30	Brn-3c	BDNF	18998(Tax:10090)	12064(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Brn-3c -LRB- POU4F3 -RRB- regulates BDNF and NT-3 promoter activity .
8876240	0	Brn-4	67,72	D1A	23,26	Brn-4	D1A	29589(Tax:10116)	24316(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of striatal D1A dopamine receptor gene transcription by Brn-4 .
25474202	0	Brn-4	15,20	IGF-1	0,5	Brn-4	IGF-1	5456	3479	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	IGF-1 Promotes Brn-4 Expression and Neuronal Differentiation of Neural Stem Cells via the PI3K/Akt Pathway .
17933456	0	Brn-5	21,26	Pit-1	79,84	Brn-5	Pit-1	5463	5449	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of mPOU -LRB- Brn-5 -RRB- , a class VI POU protein , in the gene expression of Pit-1 as well as PRL .
16838370	0	Brn3a	48,53	FGF10	14,19	Brn3a	FGF10	18996(Tax:10090)	14165(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of FGF10 by POU transcription factor Brn3a in the developing trigeminal ganglion .
9582431	0	Brn3a	29,34	NT-3	0,4	Brn3a	NT-3	18996(Tax:10090)	18205(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons .
22162750	0	Bro1	78,82	ALIX	73,77	Bro1	ALIX	856021(Tax:4932)	10015	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding .
21263029	0	Bro1	0,4	Snf7	16,20	Bro1	Snf7	856021(Tax:4932)	850712(Tax:4932)	Gene	Gene	binding|advmod|START_ENTITY binding|nmod|END_ENTITY	Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast .
12045184	0	Broad-Complex	126,139	DRONC	43,48	Broad-Complex	DRONC	44505(Tax:7227)	39173(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex .
18026869	0	Brp44l	61,67	brain_protein_44-like	38,59	Brp44l	brain protein 44-like	51660	51660	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The molecular characterization of the brain_protein_44-like -LRB- Brp44l -RRB- gene of Gekko japonicus and its expression changes in spinal cord after tail amputation .
19254709	0	Brpf1	0,5	MOZ	24,27	Brpf1	MOZ	78783(Tax:10090)	244349(Tax:10090)	Gene	Gene	START_ENTITY|appos|subunit subunit|nmod|complex complex|compound|END_ENTITY	Brpf1 , a subunit of the MOZ histone_acetyl_transferase complex , maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons .
23704370	0	Brr2	27,31	RNA_helicase	14,26	Brr2	RNA helicase	23020	9879	Gene	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of RNA_helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8 .
19393317	0	Bruno	0,5	germ_cell-less	27,41	Bruno	germ cell-less	34648(Tax:7227)	35864(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Bruno negatively regulates germ_cell-less expression in a BRE-independent manner .
12591598	0	Bruno	0,5	gurken	16,22	Bruno	gurken	34648(Tax:7227)	34171(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Bruno regulates gurken during Drosophila oogenesis .
17301411	0	Bruton_Tyrosine_Kinase	17,39	BTK	41,44	Bruton Tyrosine Kinase	BTK	695	695	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Screening of the Bruton_Tyrosine_Kinase -LRB- BTK -RRB- Gene Mutations in 13 Iranian Patients with Presumed X-Linked_Agammaglobulinemia .
23360303	0	Bruton_tyrosine_kinase	4,26	BTK	28,31	Bruton tyrosine kinase	BTK	695	695	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	The Bruton_tyrosine_kinase -LRB- BTK -RRB- inhibitor PCI-32765 synergistically increases proteasome inhibitor activity in diffuse_large-B_cell_lymphoma -LRB- DLBCL -RRB- and mantle_cell_lymphoma -LRB- MCL -RRB- cells sensitive or resistant to bortezomib .
16644721	0	Bruton_tyrosine_kinase	14,36	Pin1	69,73	Bruton tyrosine kinase	Pin1	695	5300	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Bruton_tyrosine_kinase by the peptidylprolyl isomerase Pin1 .
9347917	0	Brx1	23,27	Rieg	29,33	Brx1	Rieg	18741(Tax:10090)	18741(Tax:10090)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Expression patterns of Brx1 -LRB- Rieg gene -RRB- , Sonic_hedgehog , Nkx2 .2 , Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation .
14988731	0	Bsd2	0,4	Rsp5	32,36	Bsd2	Rsp5	852593(Tax:4932)	856862(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins .
17916651	0	Bsep	91,95	TNF-alpha	32,41	Bsep	TNF-alpha	83569(Tax:10116)	24835(Tax:10116)	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	Obstructive cholestasis induces TNF-alpha - and IL-1 - mediated periportal downregulation of Bsep and zonal regulation of Ntcp , Oatp1a4 , and Oatp1b2 .
14678827	0	Bsx	0,3	Brain_Specific_homeoboX	31,54	Bsx	Brain Specific homeoboX	244813(Tax:10090)	244813(Tax:10090)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Bsx , an evolutionary conserved Brain_Specific_homeoboX gene expressed in the septum , epiphysis , mammillary bodies and arcuate nucleus .
17485440	0	Bsx	32,35	brain-specific_homeobox	2,25	Bsx	brain-specific homeobox	244813(Tax:10090)	244813(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A brain-specific_homeobox gene , Bsx , is essential for proper postnatal growth and nursing .
17353277	0	Bsx1a	62,67	Bsx1b	85,90	Bsx1a	Bsx1b	244813(Tax:10090)	244813(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY END_ENTITY|nsubj|analysis	Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform , Bsx1b .
17353277	0	Bsx1b	85,90	Bsx1a	62,67	Bsx1b	Bsx1a	244813(Tax:10090)	244813(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform , Bsx1b .
10617598	0	Btg1	32,36	Hoxb9	103,108	Btg1	Hoxb9	694	3219	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation .
14610042	0	Btk	63,66	B_cell_antigen_receptor	4,27	Btk	B cell antigen receptor	695	613	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	The B_cell_antigen_receptor controls integrin activity through Btk and PLCgamma2 .
21659545	0	Btk	0,3	DAP12	42,47	Btk	DAP12	695	7305	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Btk is a positive regulator in the TREM-1 / DAP12 signaling pathway .
26475492	0	Btk	79,82	FcyRIIB	0,7	Btk	FcyRIIB	695	2213	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	FcyRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK .
12842985	0	Btk	60,63	GPVI	37,41	Btk	GPVI	695	51206	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Tec regulates platelet activation by GPVI in the absence of Btk .
10362515	0	Btk	36,39	Sp1/3	74,79	Btk	Sp1/3	695	6667;6670	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Synergistic activation of the human Btk promoter by transcription factors Sp1/3 and PU .1 .
25213142	0	Btk	50,53	WASP	24,28	Btk	WASP	695	7454	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages .
15007095	0	Btk	0,3	erythropoietin	45,59	Btk	erythropoietin	695	2056	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors .
10383938	1	Btk	41,44	xid	45,48	Btk	xid	12229(Tax:10090)	12229(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	CBA/N _ mice carrying the defective Btk -LRB- xid -RRB- gene are resistant to pristane-induced plasmacytomagenesis .
10191121	0	Btn1p	28,33	Cln3p	62,67	Btn1p	Cln3p	853387(Tax:4932)	1201	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Studies of pH regulation by Btn1p , the yeast homolog of human Cln3p .
9914369	0	Bub1	91,95	Bub3	58,62	Bub1	Bub3	33758(Tax:7227)	43490(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod .
26223641	0	Bub1	0,4	PCNA	35,39	Bub1	PCNA	699	5111	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Bub1 in complex with LANA recruits PCNA to regulate KSHV latent replication and DNA translesion synthesis .
18081426	0	Bub1	0,4	Sgo1	20,24	Bub1	Sgo1	853100(Tax:4932)	854240(Tax:4932)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis .
15604152	0	Bub1	6,10	Shugoshin	66,75	Bub1	Shugoshin	699	151648	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis .
11231148	0	Bub1	0,4	p90	40,43	Bub1	p90	398234(Tax:8355)	399376(Tax:8355)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Bub1 is activated by the protein kinase p90 -LRB- Rsk -RRB- during Xenopus oocyte maturation .
11959999	0	Bub2	49,53	Bfa1	0,4	Bub2	Bfa1	855077(Tax:4932)	853513(Tax:4932)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces_cerevisiae .
9914369	0	Bub3	58,62	Bub1	91,95	Bub3	Bub1	43490(Tax:7227)	33758(Tax:7227)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Localization of the Drosophila checkpoint control protein Bub3 to the kinetochore requires Bub1 but not Zw10 or Rod .
11726501	0	Bub3	0,4	Mad2	22,26	Bub3	Mad2	9184	4085	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Bub3 interaction with Mad2 , Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores .
16600213	0	BubR1	97,102	Cdc20	52,57	BubR1	Cdc20	701	991	Gene	Gene	domain|nmod|START_ENTITY binding|nmod|domain binding|nsubj|END_ENTITY	Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1 .
19154723	0	BubR1	0,5	Cdc20	78,83	BubR1	Cdc20	701	991	Gene	Gene	terminus|compound|START_ENTITY acts|nsubj|terminus acts|nmod|APC/C APC/C|appos|END_ENTITY	BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C -LRB- Cdc20 -RRB- in interphase .
20421417	0	BubR1	49,54	Cdc20	15,20	BubR1	Cdc20	35522(Tax:7227)	34968(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Recruitment Recruitment|nmod|END_ENTITY	Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila_melanogaster .
25482201	0	BubR1	35,40	Cdc20	13,18	BubR1	Cdc20	701	991	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing .
11907259	0	BubR1	19,24	Mad2	51,55	BubR1	Mad2	701	4085	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting_complex .
17785528	0	BubR1	42,47	Plk1	18,22	BubR1	Plk1	701	5347	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions .
19503101	0	BubR1	0,5	Plk1	86,90	BubR1	Plk1	701	5347	Gene	Gene	localizes|amod|START_ENTITY centrosome|nsubj|localizes centrosome|dobj|amplification amplification|acl|regulating regulating|dobj|activity activity|amod|END_ENTITY	BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells .
23685359	0	BubR1	81,86	Polo	11,15	BubR1	Polo	35522(Tax:7227)	40232(Tax:7227)	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|nmod|phosphorylation regulates|nsubj|END_ENTITY	Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation .
20703093	0	BubR1	43,48	RAF	0,3	BubR1	RAF	701	22882	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition .
24825348	0	BubR1	36,41	SIRT2	0,5	BubR1	SIRT2	12236(Tax:10090)	64383(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	SIRT2 induces the checkpoint kinase BubR1 to increase lifespan .
24920578	0	BubR1	50,55	SIRT2	23,28	BubR1	SIRT2	12236(Tax:10090)	64383(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY span|nmod|mice extends|dobj|span extends|nsubj|END_ENTITY	Sirtuin to the rescue : SIRT2 extends life span of BubR1 mice .
25285631	0	BubR1	103,108	SIRT2	71,76	BubR1	SIRT2	701	22933	Gene	Gene	degradation|amod|START_ENTITY effects|nmod|degradation effects|compound|END_ENTITY	Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition .
25285631	0	BubR1	48,53	SIRT2	71,76	BubR1	SIRT2	701	22933	Gene	Gene	START_ENTITY|nmod|effects effects|compound|END_ENTITY	Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition .
19139399	0	BubR1	62,67	TAp73	0,5	BubR1	TAp73	12236(Tax:10090)	22062(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY modulating|dobj|activity regulates|advcl|modulating regulates|nsubj|END_ENTITY	TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity .
25002677	0	Bud3	0,4	Cdc42	15,20	Bud3	Cdc42	850345(Tax:4932)	850930(Tax:4932)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Bud3 activates Cdc42 to establish a proper growth site in budding yeast .
12853472	0	Buffy	0,5	Bcl-2	20,25	Buffy	Bcl-2	36251(Tax:7227)	53585(Tax:7227)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Buffy , a Drosophila Bcl-2 protein , has anti-apoptotic and cell cycle inhibitory functions .
10958669	0	Bul1	88,92	glycogen_synthase_kinase_3	6,32	Bul1	glycogen synthase kinase 3	855318(Tax:4932)	855170(Tax:4932)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Yeast glycogen_synthase_kinase_3 is involved in protein degradation in cooperation with Bul1 , Bul2 , and Rsp5 .
20149264	0	Bunched_A	45,54	Madm	0,4	Bunched A	Madm	34665(Tax:7227)	40710(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Madm -LRB- Mlf1_adapter_molecule -RRB- cooperates with Bunched_A to promote growth in Drosophila .
22523498	0	Butyrylcholinesterase	105,126	BCHE	92,96	Butyrylcholinesterase	BCHE	590	590	Gene	Gene	Gene|nmod|START_ENTITY Gene|compound|END_ENTITY	Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase .
20807286	0	Butyrylcholinesterase	0,21	amylin	40,46	Butyrylcholinesterase	amylin	590	3375	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic_syndrome .
10333295	0	Butyrylcholinesterase	0,21	transferrin	40,51	Butyrylcholinesterase	transferrin	590	7018	Gene	Gene	complexed|nsubjpass|START_ENTITY complexed|nmod|END_ENTITY	Butyrylcholinesterase is complexed with transferrin in chicken serum .
18957080	0	Bv8	34,37	IL-10	48,53	Bv8	IL-10	50501(Tax:10090)	16153(Tax:10090)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|compound|END_ENTITY	The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin_receptor-1 .
22528488	0	Bv8	13,16	granulocyte_colony-stimulating_factor	31,68	Bv8	granulocyte colony-stimulating factor	60675	1440	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Induction of Bv8 expression by granulocyte_colony-stimulating_factor in CD11b + Gr1 + cells : key role of Stat3 signaling .
18541910	0	Bves	0,4	GEFT	29,33	Bves	GEFT	11149	115557	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Bves directly interacts with GEFT , and controls cell shape and movement through regulation of Rac1/Cdc42 activity .
17411378	0	Bw4	39,42	KIR3DS1	8,15	Bw4	KIR3DS1	474272	3813	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8 + T cell epitopes .
9569025	0	Bx42	73,77	Skip	35,39	Bx42	Skip	31840(Tax:7227)	22938	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	The Ski_oncoprotein interacts with Skip , the human homolog of Drosophila Bx42 .
17055491	0	Bysl	4,8	bystin	23,29	Bysl	bystin	53414(Tax:10090)	705	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	The Bysl gene product , bystin , is essential for survival of mouse embryos .
2106256	0	C-1	47,50	CO2	20,23	C-1	CO2	3183	717	Gene	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Recovery of labeled CO2 during the infusion of C-1 - vs C-2-labeled_acetate : implications for tracer studies of substrate oxidation .
1548181	0	C-1027	52,58	Aminopeptidase	0,14	C-1027	Aminopeptidase	1038631(Tax:199310)	10404	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Aminopeptidase activity of an antitumor antibiotic , C-1027 .
23688499	0	C-1748	110,116	Pregnane_X_receptor	0,19	C-1748	Pregnane X receptor	1035532(Tax:199310)	8856	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Pregnane_X_receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents , C-1748 and C-1305 , selectively diminished under hypoxia .
2648996	0	C-2	71,74	C-3	99,102	C-2	C-3	717	718	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Biosynthesis of 9-beta-D-arabinofuranosyladenine : hydrogen exchange at C-2 ' and oxygen exchange at C-3 ' of adenosine .
2648996	0	C-3	99,102	C-2	71,74	C-3	C-2	718	717	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Biosynthesis of 9-beta-D-arabinofuranosyladenine : hydrogen exchange at C-2 ' and oxygen exchange at C-3 ' of adenosine .
24319543	0	C-6	0,3	p53	21,24	C-6	p53	729	7157	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|compound|END_ENTITY	C-6 Ceramide Induces p53 Dependent Apoptosis in Human Astrocytoma Grade4 -LRB- Glioblastoma Multiforme -RRB- Cells .
9541024	0	C-CAM	27,32	tissue_transglutaminase	52,75	C-CAM	tissue transglutaminase	26365(Tax:10090)	21817(Tax:10090)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The cell adhesion molecule C-CAM is a substrate for tissue_transglutaminase .
7545673	1	C-C_CKR1	83,91	MCP3	190,194	C-C CKR1	MCP3	1230	6354	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	C-C_CKR1 , a receptor for macrophage_inflammatory_protein-1_alpha / Rantes , is also a functional receptor for MCP3 .
26740279	0	C-C_Chemokine_Receptor_Type_5	38,67	Orosomucoid_1	16,29	C-C Chemokine Receptor Type 5	Orosomucoid 1	1234	5004	Gene	Gene	Acts|nmod|START_ENTITY Acts|nsubj|END_ENTITY	Fatigue-induced Orosomucoid_1 Acts on C-C_Chemokine_Receptor_Type_5 to Enhance Muscle Endurance .
12734374	0	C-C_chemokine_ligand_2	0,22	monocyte_chemoattractant_protein-1	23,57	C-C chemokine ligand 2	monocyte chemoattractant protein-1	20296(Tax:10090)	20296(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	C-C_chemokine_ligand_2 / monocyte_chemoattractant_protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse .
19183043	0	C-C_chemokine_receptor_1	27,51	CCR1	53,57	C-C chemokine receptor 1	CCR1	57301(Tax:10116)	57301(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel pyrrolidine ureas as C-C_chemokine_receptor_1 -LRB- CCR1 -RRB- antagonists .
25604634	0	C-C_chemokine_receptor_2	45,69	CCR2	71,75	C-C chemokine receptor 2	CCR2	729230	729230	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The +190 _ G/A -LRB- rs1799864 -RRB- polymorphism in the C-C_chemokine_receptor_2 -LRB- CCR2 -RRB- gene is associated with susceptibility to multiple_sclerosis in HLA-DRB1 * 15:01 - negative individuals .
11390459	0	C-C_chemokine_receptor_5	34,58	C-C_chemokine_receptor_7	77,101	C-C chemokine receptor 5	C-C chemokine receptor 7	1234	1236	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Mammalian and viral IL-10 enhance C-C_chemokine_receptor_5 but down-regulate C-C_chemokine_receptor_7 expression by myeloid dendritic cells : impact on chemotactic responses and in vivo homing ability .
11390459	0	C-C_chemokine_receptor_7	77,101	C-C_chemokine_receptor_5	34,58	C-C chemokine receptor 7	C-C chemokine receptor 5	1236	1234	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Mammalian and viral IL-10 enhance C-C_chemokine_receptor_5 but down-regulate C-C_chemokine_receptor_7 expression by myeloid dendritic cells : impact on chemotactic responses and in vivo homing ability .
25746456	0	C-C_chemokine_receptor_type_2	0,29	CCR2	31,35	C-C chemokine receptor type 2	CCR2	12772(Tax:10090)	12772(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	C-C_chemokine_receptor_type_2 -LRB- CCR2 -RRB- signaling protects neonatal male mice with hypoxic-ischemic hippocampal_damage from developing spatial_learning_deficits .
8662823	0	C-C_chemokines_JE_and_FIC	70,95	mCCR2	37,42	C-C chemokines JE and FIC	mCCR2	20306(Tax:10090)	12772(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY expression|appos|receptor expression|nmod|END_ENTITY	Cloning and functional expression of mCCR2 , a murine receptor for the C-C_chemokines_JE_and_FIC .
17924972	0	C-C_ligand_20	71,84	Substance_P	0,11	C-C ligand 20	Substance P	6364	6863	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Substance_P regulates macrophage_inflammatory_protein_3alpha / chemokine C-C_ligand_20 -LRB- CCL20 -RRB- with heme_oxygenase-1 in human periodontal ligament cells .
17924972	0	C-C_ligand_20	71,84	heme_oxygenase-1	98,114	C-C ligand 20	heme oxygenase-1	6364	3162	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Substance_P regulates macrophage_inflammatory_protein_3alpha / chemokine C-C_ligand_20 -LRB- CCL20 -RRB- with heme_oxygenase-1 in human periodontal ligament cells .
24451065	0	C-C_motif_chemokine_ligand_2	88,116	signal_transducers_and_activators_of_transcription_1	9,61	C-C motif chemokine ligand 2	signal transducers and activators of transcription 1	6347	6772	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Elevated signal_transducers_and_activators_of_transcription_1 correlates with increased C-C_motif_chemokine_ligand_2 and C-X-C_motif_chemokine_10 levels in peripheral blood of patients with systemic_lupus_erythematosus .
7858491	0	C-FMS	70,75	M-CSF	54,59	C-FMS	M-CSF	1436	1435	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Expression and genomic configuration of GM-CSF , IL-3 , M-CSF receptor -LRB- C-FMS -RRB- , early_growth_response_gene-1 _ -LRB- EGR-1 -RRB- and M-CSF genes in primary myelodysplastic_syndromes .
1385639	0	C-FMS	38,43	M-CSF_and_its_receptor	14,36	C-FMS	M-CSF and its receptor	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of M-CSF_and_its_receptor -LRB- C-FMS -RRB- during factor-independent cell line evolution from hematopoietic progenitor cells cocultivated with gamma irradiated marrow stromal cell lines .
3258745	0	C-FOS	58,63	Transforming_growth_factor_alpha	0,32	C-FOS	Transforming growth factor alpha	14281(Tax:10090)	21802(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- induction of C-FOS and C-MYC expression in C3H 10T1/2 cells .
11597586	0	C-FOS	0,5	substance_P	49,60	C-FOS	substance P	314322(Tax:10116)	6863	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	C-FOS expression in the rat brain in response to substance_P and neurokinin_B .
26813148	0	C-Fos	34,39	Neuropeptide_Y	93,107	C-Fos	Neuropeptide Y	2353	4852	Gene	Gene	Induction|compound|START_ENTITY Contributes|nmod|Induction Contributes|nmod|END_ENTITY	An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide_Y .
24366538	0	C-JUN	17,22	GLI1	0,4	C-JUN	GLI1	3725	2735	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	GLI1 upregulates C-JUN through a specific 130-kDa isoform .
27045082	0	C-JUN	62,67	MAGE-A1	0,7	C-JUN	MAGE-A1	3725	4100	Gene	Gene	activation|amod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	MAGE-A1 promotes melanoma_proliferation and migration through C-JUN activation .
26599051	0	C-Jun	44,49	Connexin_43	16,27	C-Jun	Connexin 43	3725	2697	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Upregulation of Connexin_43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease .
16771680	0	C-Jun_N-terminal_kinase	0,23	JNK	25,28	C-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	C-Jun_N-terminal_kinase -LRB- JNK -RRB- regulation of iNOS expression in glial cells : predominant role of JNK1 isoform .
16771680	0	C-Jun_N-terminal_kinase	0,23	iNOS	44,48	C-Jun N-terminal kinase	iNOS	5599	4843	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	C-Jun_N-terminal_kinase -LRB- JNK -RRB- regulation of iNOS expression in glial cells : predominant role of JNK1 isoform .
18983466	0	C-KIT	38,43	EGFR	18,22	C-KIT	EGFR	3815	1956	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary_gland_carcinomas .
22169280	0	C-KIT	28,33	microRNA-193b	11,24	C-KIT	microRNA-193b	3815	574455	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of microRNA-193b on C-KIT protein expression and biological behaviors of K562 cells -RSB- .
10945494	0	C-Ki-ras	40,48	c-erbB-2	50,58	C-Ki-ras	c-erbB-2	3845	2064	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Multiple molecular marker testing -LRB- p53 , C-Ki-ras , c-erbB-2 -RRB- improves estimation of prognosis in potentially curative resected non-small_cell_lung_cancer .
23742652	0	C-Kit	0,5	CD117	20,25	C-Kit	CD117	3815	3815	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	C-Kit SCF receptor -LRB- CD117 -RRB- expression and KIT gene mutation in conjunctival pigmented lesions .
10729991	0	C-Kit	59,64	Sca-1	51,56	C-Kit	Sca-1	16590(Tax:10090)	110454(Tax:10090)	Gene	Gene	+|appos|START_ENTITY +|amod|END_ENTITY	Thrombopoietin stimulates murine lineage negative , Sca-1 + , C-Kit + , CD34 - cells : comparative study with stem_cell_factor or interleukin-3 .
10729991	0	C-Kit	59,64	stem_cell_factor	103,119	C-Kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	+|appos|START_ENTITY +|dep|cells cells|dep|study study|nmod|END_ENTITY	Thrombopoietin stimulates murine lineage negative , Sca-1 + , C-Kit + , CD34 - cells : comparative study with stem_cell_factor or interleukin-3 .
21876034	0	C-MAF	29,34	IL-2	0,4	C-MAF	IL-2	4094	3558	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates expression of C-MAF in human CD4 T cells .
9177412	0	C-MYC	108,113	BCL-2	45,50	C-MYC	BCL-2	4609	596	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the apoptosis-suppressing gene BCL-2 in pheochromocytoma is associated with the expression of C-MYC .
18385200	0	C-MYC	64,69	DHFR	99,103	C-MYC	DHFR	4609	1719	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate_reductase -LRB- DHFR -RRB- in high-grade osteosarcoma .
25497456	0	C-MYC	0,5	SOX2	34,38	C-MYC	SOX2	4609	6657	Gene	Gene	Target|compound|START_ENTITY Target|compound|END_ENTITY	C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells .
23088399	0	C-MYC	0,5	TIP110	17,23	C-MYC	TIP110	4609	9733	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells .
8810134	0	C-MYC	102,107	p53	64,67	C-MYC	p53	4609	7157	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|compound|END_ENTITY	Histological progression of follicular_lymphoma associated with p53 mutation and rearrangement of the C-MYC gene .
24140063	0	C-Myc	0,5	PTEN	47,51	C-Myc	PTEN	4609	5728	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells .
25660448	0	C-Nap1	60,66	ASPP1	30,35	C-Nap1	ASPP1	11190	23368	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The tumor suppressor proteins ASPP1 and ASPP2 interact with C-Nap1 and regulate centrosome linker reassembly .
16266992	0	C-RAF	52,57	B-RAF	104,109	C-RAF	B-RAF	5894	673	Gene	Gene	has|nsubj|START_ENTITY has|dobj|activity activity|nmod|END_ENTITY	Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF .
16364920	0	C-RAF	36,41	B-RAF	21,26	C-RAF	B-RAF	5894	673	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization .
23157514	0	C-RAF	44,49	DiRas3	22,28	C-RAF	DiRas3	5894	9077	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration .
19638574	0	C-RAF	105,110	KRAS	114,118	C-RAF	KRAS	5894	3845	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Sorafenib inhibits non-small_cell_lung_cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells .
22043453	0	C-Raf	0,5	K-Ras	55,60	C-Raf	K-Ras	110157(Tax:10090)	16653(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	C-Raf is required for the initiation of lung_cancer by K-Ras -LRB- G12D -RRB- .
23360980	0	C-Raf	16,21	MEK-1	0,5	C-Raf	MEK-1	5894	5604	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	MEK-1 activates C-Raf through a Ras-independent mechanism .
24371525	0	C-Reactive_Protein	56,74	Adiponectin	29,40	C-Reactive Protein	Adiponectin	1401	9370	Gene	Gene	Level|nmod|START_ENTITY Level|compound|END_ENTITY	Relation of Serum Leptin and Adiponectin Level to Serum C-Reactive_Protein : The INTERLIPID Study .
26182958	0	C-Reactive_Protein	77,95	Albumin	57,64	C-Reactive Protein	Albumin	1401	213	Gene	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	Relationship of Neutrophil-to-Lymphocyte Ratio and Serum Albumin Levels with C-Reactive_Protein in Hemodialysis Patients : Results from 2 International Cohort Studies .
26390126	0	C-Reactive_Protein	49,67	Albumin	68,75	C-Reactive Protein	Albumin	1401	213	Gene	Gene	Ratio|dep|START_ENTITY Ratio|compound|END_ENTITY	A Novel Inflammation-Based Prognostic Score , the C-Reactive_Protein / Albumin Ratio Predicts the Prognosis of Patients with Operable Esophageal_Squamous_Cell_Carcinoma .
26390126	0	C-Reactive_Protein	49,67	Albumin	68,75	C-Reactive Protein	Albumin	1401	213	Gene	Gene	Ratio|dep|START_ENTITY Ratio|compound|END_ENTITY	A Novel Inflammation-Based Prognostic Score , the C-Reactive_Protein / Albumin Ratio Predicts the Prognosis of Patients with Operable Esophageal_Squamous_Cell_Carcinoma .
17785926	0	C-Reactive_Protein	91,109	Interleukin-6	35,48	C-Reactive Protein	Interleukin-6	1401	3569	Gene	Gene	Concentrations|compound|START_ENTITY Polymorphism|nmod|Concentrations Polymorphism|compound|END_ENTITY	Effects of the Interaction between Interleukin-6 -634 C/G Polymorphism and Smoking on Serum C-Reactive_Protein Concentrations .
12687191	0	C-Reactive_Protein	16,34	Interleukin-8	70,83	C-Reactive Protein	Interleukin-8	1401	3576	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of C-Reactive_Protein and Serum_Amyloid_P_Component with Interleukin-8 and Their Role in Regulation of Neutrophil Functions .
23468057	0	C-Reactive_protein	0,18	TRAIL	33,38	C-Reactive protein	TRAIL	1401	8743	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	C-Reactive_protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway .
18796618	0	C-Reactive_protein	0,18	insulin	20,27	C-Reactive protein	insulin	1401	3630	Gene	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	C-Reactive_protein , insulin resistance , and metabolic_syndrome in a population with a high burden of subclinical_infection : insights from the Genetics of Coronary_Artery_Disease in Alaska Natives -LRB- GOCADAN -RRB- study .
21283787	0	C-Rel	10,15	Malt1	31,36	C-Rel	Malt1	5966	10892	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Selective C-Rel activation via Malt1 controls anti-fungal T -LRB- H -RRB- -17 immunity by dectin-1 and dectin-2 .
16963620	0	C-Rel	18,23	nitric-oxide_synthase-2	27,50	C-Rel	nitric-oxide synthase-2	5966	4843	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Essential role of C-Rel in nitric-oxide_synthase-2 transcriptional activation : time-dependent control by salicylate .
9735325	0	C-Src	0,5	ErbB2	20,25	C-Src	ErbB2	6714	2064	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells .
22962429	0	C-Type_Natriuretic_Peptide	0,26	CNP	28,31	C-Type Natriuretic Peptide	CNP	4880	4880	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	C-Type_Natriuretic_Peptide -LRB- CNP -RRB- levels are altered in boys with Klinefelter_syndrome .
25556565	0	C-Type_Natriuretic_Peptide	22,48	IL-1b	114,119	C-Type Natriuretic Peptide	IL-1b	4880	3553	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Controlled Release of C-Type_Natriuretic_Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1b in Cartilage Explants .
26272362	0	C-X-C_Chemokine_Receptor	55,79	CXCL16	31,37	C-X-C Chemokine Receptor	CXCL16	10663	58191	Gene	Gene	START_ENTITY|nsubj|Significance Significance|nmod|END_ENTITY	The Prognostic Significance of CXCL16 and Its Receptor C-X-C_Chemokine_Receptor 6 in Prostate_Cancer .
10467326	0	C-erbB-2	14,22	HER-2	23,28	C-erbB-2	HER-2	2064	2064	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of C-erbB-2 / HER-2 in patients with metastatic breast_cancer undergoing high-dose_chemotherapy and autologous blood stem cell support .
7927925	0	C-erbB-2	36,44	p185	59,63	C-erbB-2	p185	2064	8661	Gene	Gene	product|compound|START_ENTITY activity|nmod|product activity|appos|END_ENTITY	The tyrosine kinase activity of the C-erbB-2 gene product -LRB- p185 -RRB- is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin .
8600074	0	C-erbB-2	155,163	p185	173,177	C-erbB-2	p185	2064	8661	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Endometrial_adenocarcinoma of endometrioid subtype with squamous differentiation : an immunohistochemical study of MIB-1 -LRB- ki-67 paraffin -RRB- , cathepsin_D , and C-erbB-2 protein -LRB- p185 -RRB- .
21566906	0	C-erbb-2	135,143	p53	20,23	C-erbb-2	p53	2064	7157	Gene	Gene	cathepsin-d|amod|START_ENTITY value|amod|cathepsin-d value|nmod|expression expression|compound|END_ENTITY	Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis , epidermal_growth-factor_receptor , C-erbb-2 , cathepsin-d , DNA-ploidy , parameters of cell-kinetics and conventional features .
8305020	0	C-fms	0,5	M-CSF	44,49	C-fms	M-CSF	1436	1435	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	C-fms expression in B-cells and response to M-CSF .
2076099	0	C-fos	0,5	c-myc	7,12	C-fos	c-myc	2353	4609	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	C-fos , c-myc and IL-2R mRNA expression in PHA activated T lymphocytes treated with a monoclonal anti-HLA class I antibody -LRB- MAb 01.65 -RRB- .
19828354	0	C-fos	0,5	fos-B	7,12	C-fos	fos-B	14281(Tax:10090)	14282(Tax:10090)	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	C-fos , fos-B , c-jun and dusp-1 expression in the mouse heart after single and repeated methamphetamine administration .
15157984	0	C-fos	0,5	neuropeptide_Y	16,30	C-fos	neuropeptide Y	14281(Tax:10090)	109648(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	C-fos regulates neuropeptide_Y expression in mouse dentate gyrus .
14627919	0	C-jun_N-terminal_kinase	0,23	JNK	25,28	C-jun N-terminal kinase	JNK	5599	5599	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	C-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitor , SP600125 , blocks interleukin _ -LRB- IL -RRB- -6 - induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- production : cyclosporine_A partially mimics this inhibitory effect .
15512818	0	C-kit	0,5	CD117	16,21	C-kit	CD117	3815	3815	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	C-kit receptor -LRB- CD117 -RRB- expression on plasma cells in monoclonal_gammopathies .
22846208	0	C-kit	32,37	CD117	39,44	C-kit	CD117	3815	3815	Gene	Gene	expression|nmod|START_ENTITY Evaluation|nmod|expression Evaluation|appos|END_ENTITY	Evaluation of the expression of C-kit -LRB- CD117 -RRB- in ependymomas and oligodendrogliomas .
8605274	0	C-kit	0,5	CD117	16,21	C-kit	CD117	3815	3815	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	C-kit receptor -LRB- CD117 -RRB- expression in acute_leukemia .
24834842	0	C-kit	26,31	CD34	18,22	C-kit	CD34	3815	947	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	The Expression of CD34 -LRB- + -RRB- / C-kit -LRB- + -RRB- Stem Cells in Peripheral Blood in Infants After Deep_Hypothermia_Circulatory Arrest .
16405759	0	C-kit	32,37	PDGFRbeta	88,97	C-kit	PDGFRbeta	3815	5159	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression and significance of C-kit and platelet-derived_growth_factor_receptor-beta -LRB- PDGFRbeta -RRB- in esophageal_carcinoma -RSB- .
10350335	0	C-kit_receptor	18,32	CD117	34,39	C-kit receptor	CD117	3815	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the C-kit_receptor -LRB- CD117 -RRB- is a feature of almost all subtypes of de novo acute_myeloblastic_leukemia -LRB- AML -RRB- , including cytogenetically good-risk AML , and lacks prognostic significance .
12532785	0	C-myc	113,118	Bcl-2	205,210	C-myc	Bcl-2	4609	596	Gene	Gene	adenovirus|nmod|START_ENTITY adenovirus|nmod|high-expression high-expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- In vitro and in vivo studies on the biologic effects and molecular mechanism of recombinant RA538 and antisense C-myc adenovirus on human gastric , esophageal and cancer cell lines with high-expression of Bcl-2 gene -RSB- .
12394763	0	C-myc	57,62	Beta-catenin	0,12	C-myc	Beta-catenin	4609	1499	Gene	Gene	expression|nmod|START_ENTITY correlate|nmod|expression correlate|nsubj|mutations mutations|amod|END_ENTITY	Beta-catenin mutations correlate with over expression of C-myc and cyclin_D1 Genes in bladder_cancer .
24147952	0	C-myc	87,92	IMP1	60,64	C-myc	IMP1	4609	10642	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
21813470	0	C-myc	104,109	MTA1	91,95	C-myc	MTA1	4609	9112	Gene	Gene	upregulating|nmod|START_ENTITY upregulating|dobj|END_ENTITY	Overexpression of EIF5A2 promotes colorectal_carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition .
24147952	0	C-myc	87,92	P16	66,69	C-myc	P16	4609	1029	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	C-myc	87,92	P53	55,58	C-myc	P53	4609	7157	Gene	Gene	Survivn|appos|START_ENTITY Survivn|compound|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	C-myc	87,92	P62	82,85	C-myc	P62	4609	23636	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
25578561	0	C-myc	10,15	SOD2	0,4	C-myc	SOD2	4609	6648	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	SOD2 is a C-myc target gene that promotes the migration and invasion of tongue_squamous_cell_carcinoma involving cancer stem-like cells .
19084934	0	C-myc	23,28	Tp53	17,21	C-myc	Tp53	4609	7157	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Tissue array for Tp53 , C-myc , CCND1 gene over-expression in different tumors .
1776859	0	C-myc	0,5	c-myb	29,34	C-myc	c-myc	4609	4609	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	C-myc overexpression , c-mil , c-myb expression in a breast_tumor cell line .
24147952	0	C-myc	87,92	cyclin_B1	71,80	C-myc	cyclin B1	4609	891	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
20201372	0	C-myc	79,84	mad1	86,90	C-myc	mad1	4609	4084	Gene	Gene	p53|compound|START_ENTITY p53|dep|END_ENTITY	-LSB- Development of a set of diagnostic test systems for analysis of expression of C-myc , mad1 , max , p53 , and E2F1 gene oncomarkers by the reverse transcription reaction-polymerase chain reaction alignment technique -RSB- .
20201372	0	C-myc	79,84	max	92,95	C-myc	max	4609	4149	Gene	Gene	p53|compound|START_ENTITY p53|dep|END_ENTITY	-LSB- Development of a set of diagnostic test systems for analysis of expression of C-myc , mad1 , max , p53 , and E2F1 gene oncomarkers by the reverse transcription reaction-polymerase chain reaction alignment technique -RSB- .
7831152	0	C-myc	33,38	p53	43,46	C-myc	p53	4609	7157	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Mycosis fungoides : expression of C-myc p62 p53 , bcl-2 and PCNA proteins and absence of association with Epstein-Barr_virus .
7831152	0	C-myc	33,38	p62	39,42	C-myc	p62	4609	23636	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Mycosis fungoides : expression of C-myc p62 p53 , bcl-2 and PCNA proteins and absence of association with Epstein-Barr_virus .
8352531	0	C-myc	14,19	p62	20,23	C-myc	p62	4609	23636	Gene	Gene	oncoprotein|amod|START_ENTITY oncoprotein|amod|END_ENTITY	Expression of C-myc p62 oncoprotein in multiple_myeloma : an immunohistochemical study of 180 cases .
976638	0	C-peptide	6,15	CPR	34,37	C-peptide	CPR	3630	5447	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Human C-peptide immunoreactivity -LRB- CPR -RRB- in blood and urine - evaluation of a radioimmunoassay method and its clinical applications .
18299313	0	C-peptide	43,52	IL-1ra	15,21	C-peptide	IL-1ra	3630	3557	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes .
16803888	0	C-raf	14,19	Rheb	0,4	C-raf	Rheb	5894	6009	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization .
26130946	0	C-reactive_Protein	37,55	APOE	0,4	C-reactive Protein	APOE	1401	348	Gene	Gene	Levels|compound|START_ENTITY Associated|nmod|Levels Associated|nsubj|Polymorphism Polymorphism|compound|END_ENTITY	APOE Polymorphism Is Associated with C-reactive_Protein Levels but Not with White Blood Cell Count : Dong-gu Study and Namwon Study .
25748492	0	C-reactive_Protein	0,18	Interleukin-6	106,119	C-reactive Protein	Interleukin-6	1401	3569	Gene	Gene	Expression|compound|START_ENTITY Up-regulated|nsubj|Expression Up-regulated|nmod|END_ENTITY	C-reactive_Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with Interleukin-6 .
26027989	0	C-reactive_Protein	123,141	Pentraxin_3	23,34	C-reactive Protein	Pentraxin 3	1401	5806	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Elevated Expression of Pentraxin_3 in Anti-neutrophil Cytoplasmic Antibody-associated Glomerulonephritis with Normal Serum C-reactive_Protein .
16511556	0	C-reactive_protein	73,91	APOE	40,44	C-reactive protein	APOE	1401	348	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|variation variation|amod|END_ENTITY	Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive_protein , LDL-cholesterol , and apoE protein .
20074603	0	C-reactive_protein	43,61	APOE	0,4	C-reactive protein	APOE	1401	348	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	APOE polymorphism and its effect on plasma C-reactive_protein levels in a large general population sample .
24305621	0	C-reactive_protein	0,18	APOE	20,24	C-reactive protein	APOE	1401	348	Gene	Gene	genotype|advmod|START_ENTITY genotype|nsubj|END_ENTITY	C-reactive_protein , APOE genotype and longitudinal_cognitive_change in an older population .
18451326	0	C-reactive_protein	22,40	Adiponectin	0,11	C-reactive protein	Adiponectin	1401	9370	Gene	Gene	synthesis|amod|START_ENTITY decreases|dobj|synthesis decreases|nsubj|END_ENTITY	Adiponectin decreases C-reactive_protein synthesis and secretion from endothelial cells : evidence for an adipose tissue-vascular loop .
20978825	0	C-reactive_protein	20,38	Adiponectin	0,11	C-reactive protein	Adiponectin	1401	9370	Gene	Gene	expression|amod|START_ENTITY reduces|dobj|expression reduces|nsubj|END_ENTITY	Adiponectin reduces C-reactive_protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells .
20538278	0	C-reactive_protein	23,41	Angiotensin_II	0,14	C-reactive protein	Angiotensin II	1401	183	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces C-reactive_protein expression through ERK1/2 and JNK signaling in human aortic endothelial cells .
24021937	0	C-reactive_protein	23,41	Angiotensin_II	0,14	C-reactive protein	Angiotensin II	1401	183	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces C-reactive_protein expression via AT1-ROS-MAPK-NF-kB signal pathway in hepatocytes .
17669410	0	C-reactive_protein	7,25	ApoE	61,65	C-reactive protein	ApoE	12944(Tax:10090)	11816(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Native C-reactive_protein induces endothelial_dysfunction in ApoE - / - mice : implications for iNOS and reactive oxygen species .
16456095	0	C-reactive_protein	127,145	C-reactive_protein	19,37	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of modified C-reactive_protein on complement activation : a possible complement regulatory role of modified or monomeric C-reactive_protein in atherosclerotic_lesions .
16456095	0	C-reactive_protein	19,37	C-reactive_protein	127,145	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of modified C-reactive_protein on complement activation : a possible complement regulatory role of modified or monomeric C-reactive_protein in atherosclerotic_lesions .
17531570	0	C-reactive_protein	35,53	C-reactive_protein	74,92	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of values of wide-range C-reactive_protein to high-sensitivity C-reactive_protein in patients undergoing coronary angiography .
17531570	0	C-reactive_protein	74,92	C-reactive_protein	35,53	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of values of wide-range C-reactive_protein to high-sensitivity C-reactive_protein in patients undergoing coronary angiography .
18217154	0	C-reactive_protein	13,31	C-reactive_protein	76,94	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	effect|nmod|START_ENTITY effect|parataxis|transgenic_mice transgenic_mice|amod|END_ENTITY	No effect of C-reactive_protein on early atherosclerosis in LDLR - / - / human C-reactive_protein transgenic_mice .
18217154	0	C-reactive_protein	76,94	C-reactive_protein	13,31	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	transgenic_mice|amod|START_ENTITY effect|parataxis|transgenic_mice effect|nmod|END_ENTITY	No effect of C-reactive_protein on early atherosclerosis in LDLR - / - / human C-reactive_protein transgenic_mice .
18508060	0	C-reactive_protein	120,138	C-reactive_protein	24,42	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	Correlation|nmod|START_ENTITY expression|dep|Correlation expression|nmod|END_ENTITY	Increased expression of C-reactive_protein and tissue_factor in acute_coronary_syndrome_lesions : Correlation with serum C-reactive_protein , angioscopic findings , and modification by statins .
18508060	0	C-reactive_protein	24,42	C-reactive_protein	120,138	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	expression|nmod|START_ENTITY expression|dep|Correlation Correlation|nmod|END_ENTITY	Increased expression of C-reactive_protein and tissue_factor in acute_coronary_syndrome_lesions : Correlation with serum C-reactive_protein , angioscopic findings , and modification by statins .
14522018	0	C-reactive_protein	36,54	C/EBPbeta	97,106	C-reactive protein	C/EBPbeta	1401	1051	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|advcl|facilitating facilitating|dobj|binding binding|nmod|END_ENTITY	Transcription factor c-Rel enhances C-reactive_protein expression by facilitating the binding of C/EBPbeta to the promoter .
17335903	0	C-reactive_protein	74,92	C/EBPbeta	30,39	C-reactive protein	C/EBPbeta	1401	1051	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter enhances|xcomp|binding enhances|nsubj|interaction interaction|nmod|C-Rel C-Rel|nmod|END_ENTITY	The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive_protein gene promoter .
17335903	0	C-reactive_protein	74,92	C/EBPbeta	49,58	C-reactive protein	C/EBPbeta	1401	1051	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|nsubj|END_ENTITY	The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive_protein gene promoter .
18684932	0	C-reactive_protein	28,46	C/EBPbeta	11,20	C-reactive protein	C/EBPbeta	1401	1051	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Binding of C/EBPbeta to the C-reactive_protein -LRB- CRP -RRB- promoter in Hep3B cells is associated with transcription of CRP mRNA .
2005402	0	C-reactive_protein	37,55	C1q	88,91	C-reactive protein	C1q	1401	712	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Binding and complement activation by C-reactive_protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive_protein and C1q .
16389569	0	C-reactive_protein	0,18	CD11b	28,33	C-reactive protein	CD11b	1401	3684	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	C-reactive_protein mediates CD11b expression in monocytes through the non-receptor tyrosine kinase , Syk , and calcium mobilization but not through cytosolic peroxides .
22088250	0	C-reactive_protein	32,50	CD14	94,98	C-reactive protein	CD14	12944(Tax:10090)	12475(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
9653079	0	C-reactive_protein	30,48	CD4	0,3	C-reactive protein	CD4	1401	920	Gene	Gene	tolerance|nmod|START_ENTITY tolerance|compound|END_ENTITY	CD4 T cell tolerance to human C-reactive_protein , an inducible serum protein , is mediated by medullary thymic epithelium .
10379687	0	C-reactive_protein	0,18	CRP	20,23	C-reactive protein	CRP	20468888	20468888	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- response patterns in neonatal_septicaemia .
10880233	0	C-reactive_protein	106,124	CRP	126,129	C-reactive protein	CRP	12944(Tax:10090)	12944(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Role of STAT3 and C/EBP in cytokine-dependent expression of the mouse serum_amyloid_P-component -LRB- SAP -RRB- and C-reactive_protein -LRB- CRP -RRB- genes .
11947917	0	C-reactive_protein	26,44	CRP	46,49	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the human C-reactive_protein -LRB- CRP -RRB- gene , plasma concentrations of CRP , and the risk of future arterial thrombosis .
14625403	0	C-reactive_protein	23,41	CRP	43,46	C-reactive protein	CRP	488629(Tax:9615)	488629(Tax:9615)	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of serum C-reactive_protein -LRB- CRP -RRB- in healthy beagle_dogs of various ages and pregnant beagle_dogs .
15504106	0	C-reactive_protein	58,76	CRP	78,81	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Persistent endothelial_dysfunction is related to elevated C-reactive_protein -LRB- CRP -RRB- levels in Type_II_diabetic patients after acute_myocardial_infarction .
15542929	0	C-reactive_protein	6,24	CRP	26,29	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum C-reactive_protein -LRB- CRP -RRB- levels and insulin resistance in non-obese women with polycystic_ovarian_syndrome , and effect of bicalutamide on hirsutism , CRP levels and insulin resistance .
15778807	0	C-reactive_protein	39,57	CRP	59,62	C-reactive protein	CRP	1401	1401	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Single-nucleotide polymorphisms in the C-reactive_protein -LRB- CRP -RRB- gene promoter that affect transcription factor binding , alter transcriptional activity , and associate with differences in baseline serum CRP level .
15889566	0	C-reactive_protein	24,42	CRP	44,47	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The prognostic value of C-reactive_protein -LRB- CRP -RRB- levels in patients with acute ischaemic_stroke .
15897982	0	C-reactive_protein	25,43	CRP	45,48	C-reactive protein	CRP	1401	1401	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Polymorphisms within the C-reactive_protein -LRB- CRP -RRB- promoter region are associated with plasma CRP levels .
16832152	0	C-reactive_protein	20,38	CRP	40,43	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the C-reactive_protein -LRB- CRP -RRB- gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese .
16984505	0	C-reactive_protein	33,51	CRP	53,56	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The +1059 G/C polymorphism in the C-reactive_protein -LRB- CRP -RRB- gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn 's _ disease .
1735220	0	C-reactive_protein	0,18	CRP	20,23	C-reactive protein	CRP	1401	1401	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- levels after elective orthopedic surgery .
17395501	0	C-reactive_protein	24,42	CRP	44,47	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Interpretation of serum C-reactive_protein -LRB- CRP -RRB- levels for cardiovascular_disease risk is complicated by race , pulmonary_disease , body mass index , gender , and osteoarthritis .
17477779	0	C-reactive_protein	27,45	CRP	47,50	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Associations between serum C-reactive_protein -LRB- CRP -RRB- levels and polymorphisms of CRP , _ interleukin_1B , and tumor necrosis factor genes among Japanese health checkup examinees .
18083122	0	C-reactive_protein	26,44	CRP	46,49	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the human C-reactive_protein -LRB- CRP -RRB- gene , serum concentrations of CRP , and the difference between intracranial and extracranial atherosclerosis .
1810225	0	C-reactive_protein	11,29	CRP	31,34	C-reactive protein	CRP	1401	1401	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of C-reactive_protein -LRB- CRP -RRB- by human peripheral blood lymphocytes in vivo .
18167554	0	C-reactive_protein	0,18	CRP	20,23	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- gene polymorphisms , CRP levels , and risk of incident coronary_heart_disease in two nested case-control studies .
18266777	0	C-reactive_protein	13,31	CRP	33,36	C-reactive protein	CRP	1401	1401	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	No effect of C-reactive_protein -LRB- CRP -RRB- haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation .
18793001	0	C-reactive_protein	21,39	CRP	41,44	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variation in C-reactive_protein -LRB- CRP -RRB- gene may be associated with risk of systemic_lupus_erythematosus and CRP concentrations .
19373547	0	C-reactive_protein	6,24	CRP	26,29	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum C-reactive_protein -LRB- CRP -RRB- levels in cancer patients are linked with tumor burden and are reduced by anti-hypertensive medication .
19410251	0	C-reactive_protein	15,33	CRP	35,38	C-reactive protein	CRP	1401	1401	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of C-reactive_protein -LRB- CRP -RRB- gene allelic variants with serum CRP levels and hypertension in Turkish adults .
19624831	0	C-reactive_protein	27,45	CRP	47,50	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional analysis of the C-reactive_protein -LRB- CRP -RRB- gene -717 A > G polymorphism associated with coronary_heart_disease .
20552244	0	C-reactive_protein	28,46	CRP	48,51	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphism of the C-reactive_protein -LRB- CRP -RRB- gene and a deep_infection focus determine maximal serum CRP level in Staphylococcus_aureus bacteremia .
21413847	0	C-reactive_protein	20,38	CRP	40,43	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the C-reactive_protein -LRB- CRP -RRB- gene affects CRP levels in plasma and one early marker of atherosclerosis in men : The Health 2000 Survey .
21720757	0	C-reactive_protein	0,18	CRP	20,23	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- gene polymorphisms : implication in CRP plasma levels and susceptibility to acute_myocardial_infarction .
21737650	0	C-reactive_protein	15,33	CRP	35,38	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of C-reactive_protein -LRB- CRP -RRB- gene polymorphisms , serum CRP levels and cervical_cancer prognosis .
22467322	0	C-reactive_protein	32,50	CRP	52,55	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Comparative evaluation of serum C-reactive_protein -LRB- CRP -RRB- levels in the different histological subtypes of esophageal_cancer -LRB- squamous_cell_carcinoma and adenocarcinoma_of_esophagus -RRB- .
22926497	0	C-reactive_protein	6,24	CRP	26,29	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum C-reactive_protein -LRB- CRP -RRB- levels in young adults can be used to discriminate between inflammatory and non-inflammatory_diarrhea .
23529581	0	C-reactive_protein	0,18	CRP	20,23	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- levels in babies with gastroschisis managed with preformed silos .
23818401	0	C-reactive_protein	24,42	CRP	44,47	C-reactive protein	CRP	1401	1401	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association between C-reactive_protein -LRB- CRP -RRB- level and biochemical failure-free survival in patients after radiation therapy for nonmetastatic adenocarcinoma_of_the_prostate .
25495587	0	C-reactive_protein	10,28	CRP	30,33	C-reactive protein	CRP	1401	1401	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of C-reactive_protein -LRB- CRP -RRB- in patients with schizophrenia , unipolar_depression and bipolar_disorder .
2593200	0	C-reactive_protein	10,28	CRP	30,33	C-reactive protein	CRP	1401	1401	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of C-reactive_protein -LRB- CRP -RRB- on surfactant function .
27068411	0	C-reactive_protein	22,40	CRP	42,45	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Short-term changes on C-reactive_protein -LRB- CRP -RRB- levels after non-surgical periodontal treatment in systemically healthy individuals .
3485499	0	C-reactive_protein	0,18	CRP	20,23	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- levels in systemic_lupus_erythematosus -LRB- SLE -RRB- .
3759147	0	C-reactive_protein	10,28	CRP	35,38	C-reactive protein	CRP	1401	1401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human C-reactive_protein gene -LRB- CRP -RRB- and serum_amyloid_P_component gene -LRB- APCS -RRB- are located on the proximal long arm of chromosome 1 .
6524861	0	C-reactive_protein	13,31	CRP	33,36	C-reactive protein	CRP	1401	1401	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The value of C-reactive_protein -LRB- CRP -RRB- determinations in patients with suspected acute_appendicitis .
8339052	0	C-reactive_protein	0,18	CRP	20,23	C-reactive protein	CRP	1401	1401	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- levels do not reflect disease status in patients with multiple_myeloma .
12945874	0	C-reactive_protein	11,29	E-selectin	71,81	C-reactive protein	E-selectin	1401	6401	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|amod|END_ENTITY	Effects of C-reactive_protein on the release of von_Willebrand factor , E-selectin , thrombomodulin and intercellular_adhesion_molecule-1 from human umbilical vein endothelial cells .
20538278	0	C-reactive_protein	23,41	ERK1/2	61,67	C-reactive protein	ERK1/2	1401	5595;5594	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Angiotensin_II induces C-reactive_protein expression through ERK1/2 and JNK signaling in human aortic endothelial cells .
19748488	0	C-reactive_protein	39,57	Endothelin-1	0,12	C-reactive protein	Endothelin-1	25419(Tax:10116)	24323(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Endothelin-1 induces the expression of C-reactive_protein in rat vascular smooth muscle cells .
19118524	0	C-reactive_protein	37,55	FXR	70,73	C-reactive protein	FXR	1401	9971	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of interleukin-6-induced C-reactive_protein expression by FXR agonists .
19155486	0	C-reactive_protein	25,43	Fc_gamma_RI	52,63	C-reactive protein	Fc gamma RI	12944(Tax:10090)	14129(Tax:10090)	Gene	Gene	activated|nmod|START_ENTITY activated|nmod|suppression suppression|compound|END_ENTITY	Macrophages activated by C-reactive_protein through Fc_gamma_RI transfer suppression of immune thrombocytopenia .
7636267	0	C-reactive_protein	0,18	Fc_gamma_RI	28,39	C-reactive protein	Fc gamma RI	1401	2209	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	C-reactive_protein binds to Fc_gamma_RI in transfected COS cells .
16899975	0	C-reactive_protein	76,94	Hepatocyte_growth_factor	0,24	C-reactive protein	Hepatocyte growth factor	1401	3082	Gene	Gene	response|nmod|START_ENTITY indicator|nmod|response indicator|nsubj|END_ENTITY	Hepatocyte_growth_factor is a better indicator of therapeutic response than C-reactive_protein within the first day of treatment in pneumonia .
9058297	0	C-reactive_protein	78,96	Hepatocyte_growth_factor	0,24	C-reactive protein	Hepatocyte growth factor	1401	3082	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Hepatocyte_growth_factor in assessment of acute pancreatitis : comparison with C-reactive_protein and interleukin-6 .
26438598	0	C-reactive_protein	59,77	HuR	105,108	C-reactive protein	HuR	1401	1994	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Post-transcriptional regulation of the inflammatory marker C-reactive_protein by the RNA-binding protein HuR and miR-637 .
8482924	0	C-reactive_protein	0,18	IL-1_alpha	43,53	C-reactive protein	IL-1 alpha	1401	3552	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|nmod|END_ENTITY	C-reactive_protein increases production of IL-1_alpha , IL-1_beta , and TNF-alpha , and expression of mRNA by human alveolar macrophages .
20978825	0	C-reactive_protein	20,38	IL-6	101,105	C-reactive protein	IL-6	1401	3569	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Adiponectin reduces C-reactive_protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells .
22108347	0	C-reactive_protein	37,55	IL-6	24,28	C-reactive protein	IL-6	1401	3569	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	Ursolic_acid suppresses IL-6 induced C-reactive_protein expression in HepG2 and protects HUVECs from injury induced by CRP .
14993508	0	C-reactive_protein	81,99	Interleukin-6	0,13	C-reactive protein	Interleukin-6	1401	3569	Gene	Gene	predictor|nmod|START_ENTITY predictor|nsubj|END_ENTITY	Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive_protein in haemodialysis patients .
17374948	0	C-reactive_protein	15,33	Interleukin-6	0,13	C-reactive protein	Interleukin-6	1401	3569	Gene	Gene	parameters|amod|START_ENTITY END_ENTITY|appos|parameters	Interleukin-6 , C-reactive_protein and biochemical parameters during prolonged intermittent fasting .
18285696	0	C-reactive_protein	64,82	Interleukin-6	0,13	C-reactive protein	Interleukin-6	1401	3569	Gene	Gene	products|amod|START_ENTITY mortality|acl|products predictor|nmod|mortality predictor|nsubj|END_ENTITY	Interleukin-6 is a better predictor of mortality as compared to C-reactive_protein , homocysteine , pentosidine and advanced oxidation protein products in hemodialysis patients .
19626399	0	C-reactive_protein	69,87	Interleukin-6	0,13	C-reactive protein	Interleukin-6	1401	3569	Gene	Gene	predictor|nmod|START_ENTITY predictor|nsubj|END_ENTITY	Interleukin-6 is a stronger prognostic predictor than high-sensitive C-reactive_protein in patients with chronic stable heart_failure .
21190868	0	C-reactive_protein	122,140	Interleukin-6	0,13	C-reactive protein	Interleukin-6	1401	3569	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients : comparison with C-reactive_protein .
8658073	0	C-reactive_protein	15,33	Interleukin-6	0,13	C-reactive protein	Interleukin-6	1401	3569	Gene	Gene	lactoferrin|amod|START_ENTITY cell|compound|lactoferrin count|nsubj|cell count|advmod|END_ENTITY	Interleukin-6 , C-reactive_protein , lactoferrin and white blood cell count in patients with S. _ aureus_septicemia .
23257175	0	C-reactive_protein	49,67	Interleukin_6	0,13	C-reactive protein	Interleukin 6	1401	3569	Gene	Gene	synthesis|amod|START_ENTITY augments|dobj|synthesis augments|nsubj|END_ENTITY	Interleukin_6 augments mechanical strain-induced C-reactive_protein synthesis via the stretch-activated channel-nuclear factor k B signal pathway .
18217154	0	C-reactive_protein	13,31	LDLR	60,64	C-reactive protein	LDLR	1401	3949	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	No effect of C-reactive_protein on early atherosclerosis in LDLR - / - / human C-reactive_protein transgenic_mice .
18217154	0	C-reactive_protein	76,94	LDLR	60,64	C-reactive protein	LDLR	1401	3949	Gene	Gene	transgenic_mice|amod|START_ENTITY effect|parataxis|transgenic_mice effect|nmod|END_ENTITY	No effect of C-reactive_protein on early atherosclerosis in LDLR - / - / human C-reactive_protein transgenic_mice .
15472120	0	C-reactive_protein	0,18	LOX-1	28,33	C-reactive protein	LOX-1	1401	4973	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	C-reactive_protein enhances LOX-1 expression in human aortic endothelial cells : relevance of LOX-1 to C-reactive_protein-induced endothelial_dysfunction .
15472120	0	C-reactive_protein	0,18	LOX-1	93,98	C-reactive protein	LOX-1	1401	4973	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|dep|relevance relevance|nmod|END_ENTITY	C-reactive_protein enhances LOX-1 expression in human aortic endothelial cells : relevance of LOX-1 to C-reactive_protein-induced endothelial_dysfunction .
19074514	0	C-reactive_protein	37,55	LOX-1	22,27	C-reactive protein	LOX-1	25419(Tax:10116)	140914(Tax:10116)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Oxidized LDL_receptor LOX-1 binds to C-reactive_protein and mediates its vascular effects .
23950953	0	C-reactive_protein	50,68	LOX-1	122,127	C-reactive protein	LOX-1	1401	4973	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|receptor receptor|compound|END_ENTITY	Electronegative low-density lipoprotein increases C-reactive_protein expression in vascular endothelial cells through the LOX-1 receptor .
16764962	0	C-reactive_protein	75,93	Leptin	0,6	C-reactive protein	Leptin	1401	3952	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Leptin , triglycerides , and interleukin_6 are independently associated with C-reactive_protein in Japanese type 2 diabetic patients .
17615382	0	C-reactive_protein	15,33	Leptin	0,6	C-reactive protein	Leptin	1401	3952	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin induces C-reactive_protein expression in vascular endothelial cells .
19008293	0	C-reactive_protein	0,18	M-CSF	27,32	C-reactive protein	M-CSF	1401	1435	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	C-reactive_protein induces M-CSF release and macrophage proliferation .
23375121	0	C-reactive_protein	42,60	MCP-4	15,20	C-reactive protein	MCP-4	1401	6357	Gene	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of MCP-4 and high-sensitivity C-reactive_protein as a marker of inflammation in obesity and chronic_periodontitis .
14592848	0	C-reactive_protein	0,18	MMP-1	30,35	C-reactive protein	MMP-1	1401	4312	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	C-reactive_protein stimulates MMP-1 expression in U937 histiocytes through Fc -LSB- gamma -RSB- RII and extracellular signal-regulated kinase pathway : : an implication of CRP involvement in plaque destabilization .
19662350	0	C-reactive_protein	46,64	MMP-9	37,42	C-reactive protein	MMP-9	1401	4318	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression and activity of MMP-9 in C-reactive_protein - induced human THP-1 mononuclear cells is related to activation of nuclear_factor_kappa-B .
25864110	0	C-reactive_protein	0,18	N-cadherin	42,52	C-reactive protein	N-cadherin	12944(Tax:10090)	12558(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	C-reactive_protein inhibits expression of N-cadherin and ZEB-1 in murine colon_adenocarcinoma .
16116232	0	C-reactive_protein	46,64	OCT-1	100,105	C-reactive protein	OCT-1	1401	5451	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of basal and induced expression of C-reactive_protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter .
26861255	0	C-reactive_protein	61,79	PCSK9	35,40	C-reactive protein	PCSK9	1401	255738	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Effect of Monoclonal Antibodies to PCSK9 on high-sensitivity C-reactive_protein levels : A Meta-Analysis of 16 Randomized Controlled Treatment Arms .
2114355	0	C-reactive_protein	21,39	PSTI	84,88	C-reactive protein	PSTI	1401	6690	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Serum interleukin_6 , C-reactive_protein and pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- as acute phase reactants after major thoraco-abdominal surgery .
25832424	0	C-reactive_protein	0,18	RAGE	30,34	C-reactive protein	RAGE	1401	101669765	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	C-reactive_protein stimulates RAGE expression in human coronary artery endothelial cells in vitro via ROS generation and ERK/NF-kB activation .
24894103	0	C-reactive_protein	6,24	Takayasu_arteritis	80,98	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Serum C-reactive_protein level but not its gene polymorphism is associated with Takayasu_arteritis .
17045300	0	C-reactive_protein	130,148	Toll-like_receptor_4	0,20	C-reactive protein	Toll-like receptor 4	1401	7099	Gene	Gene	patients|nmod|START_ENTITY enhanced|nmod|patients enhanced|nsubjpass|expressions expressions|amod|END_ENTITY	Toll-like_receptor_4 expressions on peripheral blood monocytes were enhanced in coronary_artery_disease even in patients with low C-reactive_protein .
20332628	0	C-reactive_protein	75,93	Toll-like_receptor_4	0,20	C-reactive protein	Toll-like receptor 4	25419(Tax:10116)	29260(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY activation|acl|induced mediates|dobj|activation mediates|nsubj|signaling signaling|compound|END_ENTITY	Toll-like_receptor_4 signaling mediates inflammatory activation induced by C-reactive_protein in vascular smooth muscle cells .
22088250	0	C-reactive_protein	32,50	Toll-like_receptor_4	59,79	C-reactive protein	Toll-like receptor 4	12944(Tax:10090)	21898(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
16002075	0	C-reactive_protein	0,18	VCAM-1	27,33	C-reactive protein	VCAM-1	1401	7412	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	C-reactive_protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells .
18280482	0	C-reactive_protein	0,18	VEGF-A	35,41	C-reactive protein	VEGF-A	1401	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK_1 / 2 signaling dependent pathway .
12578865	0	C-reactive_protein	26,44	adiponectin	50,61	C-reactive protein	adiponectin	1401	9370	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Reciprocal association of C-reactive_protein with adiponectin in blood stream and adipose tissue .
16188522	0	C-reactive_protein	58,76	adiponectin	32,43	C-reactive protein	adiponectin	1401	9370	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|dobj|levels	Relation of microalbuminuria to adiponectin and augmented C-reactive_protein levels in men with essential hypertension .
17641277	0	C-reactive_protein	0,18	adiponectin	28,39	C-reactive protein	adiponectin	1401	9370	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	C-reactive_protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes .
18362454	0	C-reactive_protein	15,33	adiponectin	66,77	C-reactive protein	adiponectin	1401	9370	Gene	Gene	weight|amod|START_ENTITY Combination|nmod|weight Combination|parataxis|reflects reflects|nsubj|END_ENTITY	Combination of C-reactive_protein and high molecular weight -LRB- HMW -RRB- - adiponectin reflects further metabolic_abnormalities compared with each of them alone in Japanese type 2 diabetic subjects .
25137264	0	C-reactive_protein	40,58	adiponectin	60,71	C-reactive protein	adiponectin	1401	9370	Gene	Gene	Association|appos|START_ENTITY END_ENTITY|nsubj|Association	Association between nutritional status , C-reactive_protein , adiponectin and HOMA-AD in Brazilian children .
18222566	0	C-reactive_protein	121,139	adrenomedullin	7,21	C-reactive protein	adrenomedullin	1401	133	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Plasma adrenomedullin as an independent predictor of future cardiovascular events in high-risk patients : comparison with C-reactive_protein and adiponectin .
9228512	0	C-reactive_protein	78,96	adrenomedullin	27,41	C-reactive protein	adrenomedullin	1401	133	Gene	Gene	correlation|nmod|START_ENTITY levels|dep|correlation levels|acl|circulating circulating|dobj|END_ENTITY	High levels of circulating adrenomedullin in severe illness : correlation with C-reactive_protein and evidence against the adrenal medulla as site of origin .
1711512	0	C-reactive_protein	59,77	alpha-2-macroglobulin	10,31	C-reactive protein	alpha-2-macroglobulin	1401	2	Gene	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of alpha-2-macroglobulin on cytokine-mediated human C-reactive_protein production .
16950177	0	C-reactive_protein	11,29	angiotensin_II	108,122	C-reactive protein	angiotensin II	1401	183	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|grafting grafting|amod|vitro vitro|nmod|END_ENTITY	Effects of C-reactive_protein and cholesterol on responsiveness in vitro of the internal thoracic artery to angiotensin_II in patients having coronary artery bypass grafting .
14522018	0	C-reactive_protein	36,54	c-Rel	21,26	C-reactive protein	c-Rel	1401	5966	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Transcription factor c-Rel enhances C-reactive_protein expression by facilitating the binding of C/EBPbeta to the promoter .
8850655	0	C-reactive_protein	63,81	cathepsin_G_and_elastase	83,107	C-reactive protein	cathepsin G and elastase	1401	1511	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nsubj|levels	Salivary levels of alpha_2-macroglobulin , alpha 1-antitrypsin , C-reactive_protein , cathepsin_G_and_elastase in humans with or without destructive_periodontal_disease .
20706769	0	C-reactive_protein	91,109	complement_C3	6,19	C-reactive protein	complement C3	1401	718	Gene	Gene	has|nmod|START_ENTITY has|nsubj|END_ENTITY	Serum complement_C3 has a stronger association with insulin resistance than high sensitive C-reactive_protein in non-diabetic Chinese .
21316661	0	C-reactive_protein	93,111	complement_C3	6,19	C-reactive protein	complement C3	1401	718	Gene	Gene	has|nmod|START_ENTITY has|nsubj|END_ENTITY	Serum complement_C3 has a stronger association with insulin resistance than high-sensitivity C-reactive_protein in women with polycystic_ovary_syndrome .
22301267	0	C-reactive_protein	0,18	endothelial_nitric_oxide_synthase	34,67	C-reactive protein	endothelial nitric oxide synthase	1401	4846	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	C-reactive_protein down-regulates endothelial_nitric_oxide_synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products .
10490997	0	C-reactive_protein	39,57	factor_H	107,115	C-reactive protein	factor H	1401	3075	Gene	Gene	complement|nmod|START_ENTITY complement|dep|targeting targeting|dobj|activity activity|nmod|END_ENTITY	Regulation of complement activation by C-reactive_protein : targeting the complement inhibitory activity of factor_H by an interaction with short consensus repeat domains 7 and 8-11 .
17339482	0	C-reactive_protein	70,88	factor_H	33,41	C-reactive protein	factor H	1401	3075	Gene	Gene	affects|nmod|START_ENTITY affects|nsubj|polymorphism polymorphism|nmod|END_ENTITY	Y402H polymorphism of complement factor_H affects binding affinity to C-reactive_protein .
19850925	0	C-reactive_protein	54,72	factor_H	11,19	C-reactive protein	factor H	1401	3075	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Complement factor_H binds at two independent sites to C-reactive_protein in acute phase concentrations .
11472751	0	C-reactive_protein	0,18	familial_hypercholesterolemia	36,65	C-reactive protein	familial hypercholesterolemia	1401	3949	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	C-reactive_protein in patients with familial_hypercholesterolemia : no effect of simvastatin therapy .
18602518	0	C-reactive_protein	12,30	familial_hypercholesterolemia	84,113	C-reactive protein	familial hypercholesterolemia	1401	3949	Gene	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of C-reactive_protein and carotid_intima_media_thickness in Taiwanese with familial_hypercholesterolemia .
18844495	0	C-reactive_protein	52,70	gamma-glutamyltransferase	21,46	C-reactive protein	gamma-glutamyltransferase	1401	728226	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Association of serum gamma-glutamyltransferase with C-reactive_protein levels and white blood cell count in Korean adults .
21602602	0	C-reactive_protein	9,27	glycoprotein_Iba	52,68	C-reactive protein	glycoprotein Iba	1401	2811	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Modified C-reactive_protein interacts with platelet glycoprotein_Iba .
1717278	0	C-reactive_protein	29,47	haptoglobin	70,81	C-reactive protein	haptoglobin	1401	3240	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nsubj|levels	Pretreatment serum levels of C-reactive_protein , alpha 1-antitrypsin , haptoglobin , alpha 1-acid glycoprotein and tissue polypeptide antigen in cervical_carcinoma .
18402807	0	C-reactive_protein	0,18	high-mobility_group_box-1	27,52	C-reactive protein	high-mobility group box-1	12944(Tax:10090)	15289(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	C-reactive_protein induces high-mobility_group_box-1 protein release through activation of p38MAPK in macrophage RAW264 .7 cells .
16919544	0	C-reactive_protein	31,49	insulin	136,143	C-reactive protein	insulin	1401	3630	Gene	Gene	START_ENTITY|nmod|relation relation|nmod|resistance resistance|compound|END_ENTITY	Serum levels of interleukin_6 , C-reactive_protein , vascular_cell_adhesion_molecule_1 , and monocyte_chemotactic_protein_1 in relation to insulin resistance and glucose_intolerance -- the Chennai Urban Rural Epidemiology Study -LRB- CURES -RRB- .
7646436	0	C-reactive_protein	31,49	interleukin-1	14,27	C-reactive protein	interleukin-1	1401	3552	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	The effect of interleukin-1 on C-reactive_protein expression in Hep3B cells is exerted at the transcriptional level .
10476751	0	C-reactive_protein	76,94	interleukin-6	46,59	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Assessment of measuring circulating levels of interleukin-6 , interleukin-8 , C-reactive_protein , soluble Fc gamma receptor type III , and mannose-binding_protein in febrile children with cancer and neutropenia .
11053781	0	C-reactive_protein	49,67	interleukin-6	81,94	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Alpha_tocopherol supplementation decreases serum C-reactive_protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients .
11922913	0	C-reactive_protein	107,125	interleukin-6	43,56	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubjpass|Genotype Genotype|nmod|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive_protein .
12519862	0	C-reactive_protein	110,128	interleukin-6	38,51	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels associated|advcl|circulating associated|nsubjpass|polymorphisms polymorphisms|acl|regulating regulating|dobj|expression expression|amod|END_ENTITY	Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive_protein and markers of bone resorption in postmenopausal women .
12826933	0	C-reactive_protein	76,94	interleukin-6	21,34	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	stimulated|nmod|START_ENTITY monocytes|acl|stimulated inhibits|nmod|monocytes inhibits|dobj|release release|amod|END_ENTITY	Simvastatin inhibits interleukin-6 release in human monocytes stimulated by C-reactive_protein and lipopolysaccharide .
15069709	0	C-reactive_protein	0,18	interleukin-6	35,48	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	C-reactive_protein , procalcitonin , interleukin-6 , vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric_cancer .
15781013	0	C-reactive_protein	75,93	interleukin-6	11,24	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	production|nmod|START_ENTITY produced|nmod|production produced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of interleukin-6 produced in coronary circulation on production of C-reactive_protein and coronary microvascular resistance .
16876827	0	C-reactive_protein	79,97	interleukin-6	52,65	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	expression|amod|START_ENTITY blocks|nmod|expression blocks|dobj|signaling signaling|amod|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- blocks the interleukin-6 signaling to C-reactive_protein expression in Hep3B cells by suppressing Rac-1 activation .
17003778	0	C-reactive_protein	68,86	interleukin-6	88,101	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	The longitudinal relationship between circulating concentrations of C-reactive_protein , interleukin-6 and interleukin-10 in patients undergoing resection for renal_cancer .
18653160	0	C-reactive_protein	21,39	interleukin-6	41,54	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	Correlations|nmod|START_ENTITY Correlations|appos|index index|compound|END_ENTITY	Correlations between C-reactive_protein , interleukin-6 , tumor_necrosis_factor-alpha and body mass index during senile_osteoporosis .
19267250	0	C-reactive_protein	0,18	interleukin-6	20,33	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	risk|amod|START_ENTITY risk|amod|END_ENTITY	C-reactive_protein , interleukin-6 , and prostate_cancer risk in men aged 65 years and older .
19489963	0	C-reactive_protein	76,94	interleukin-6	96,109	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	Flow mediated vasodilation and circulating concentrations of high sensitive C-reactive_protein , interleukin-6 and tumor_necrosis_factor-alpha in normal pregnancy -- The Cardiovascular Risk in Young Finns Study .
19811958	0	C-reactive_protein	62,80	interleukin-6	29,42	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|Usefulness Usefulness|nmod|test test|amod|END_ENTITY	-LSB- Usefulness of a rapid serum interleukin-6 test combined with C-reactive_protein to predict sepsis in newborns with suspicion of infection -RSB- .
2154496	0	C-reactive_protein	60,78	interleukin-6	36,49	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	expression|amod|START_ENTITY inducible|dobj|expression inducible|nsubj|elements elements|amod|responsible responsible|advcl|END_ENTITY	cis-acting elements responsible for interleukin-6 inducible C-reactive_protein gene expression .
21550586	0	C-reactive_protein	24,42	interleukin-6	133,146	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene derived|nsubjpass|expression derived|nmod|cells cells|acl|stimulated stimulated|advcl|END_ENTITY	Increased expression of C-reactive_protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-6 .
21597715	0	C-reactive_protein	20,38	interleukin-6	74,87	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	Elevations|nmod|START_ENTITY occur|nsubj|Elevations occur|advcl|circulating circulating|dobj|concentrations concentrations|amod|END_ENTITY	Elevations of serum C-reactive_protein occur independently of circulating interleukin-6 concentrations in patients with lung-cancer .
21735293	0	C-reactive_protein	14,32	interleukin-6	78,91	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	tumor_necrosis_factor_alpha|compound|START_ENTITY tumor_necrosis_factor_alpha|nummod|END_ENTITY	Evaluation of C-reactive_protein , procalcitonin , tumor_necrosis_factor_alpha , interleukin-6 , and interleukin-8 as diagnostic parameters in sepsis-related fatalities .
22223149	0	C-reactive_protein	0,18	interleukin-6	27,40	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|amod|END_ENTITY	C-reactive_protein induces interleukin-6 and thrombospondin-1 protein and mRNA expression through activation of nuclear factor - B in HK-2 cells .
23124693	0	C-reactive_protein	32,50	interleukin-6	124,137	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	levels|amod|START_ENTITY correlate|nsubj|levels correlate|nmod|index index|appos|rate rate|amod|END_ENTITY	Elevated serum high-sensitivity C-reactive_protein levels in fibromyalgia_syndrome patients correlate with body mass index , interleukin-6 , interleukin-8 , erythrocyte sedimentation rate .
23757905	0	C-reactive_protein	28,46	interleukin-6	48,61	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	leukocyte|amod|START_ENTITY leukocyte|amod|END_ENTITY	Estimation of the levels of C-reactive_protein , interleukin-6 , total leukocyte count , and differential count in peripheral blood smear of patients with chronic_periodontitis in a South Indian population .
24338120	0	C-reactive_protein	36,54	interleukin-6	21,34	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Umbilical cord serum interleukin-6 , C-reactive_protein , and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes .
24749795	0	C-reactive_protein	41,59	interleukin-6	26,39	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	status|amod|START_ENTITY status|amod|END_ENTITY	Maternal plasma levels of interleukin-6 , C-reactive_protein , vitamins_C , _ E_and_A , 8-isoprostane and oxidative status in women with preterm premature rupture_of_membranes .
24836084	0	C-reactive_protein	0,18	interleukin-6	20,33	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	necrosis|amod|START_ENTITY necrosis|amod|soluble soluble|amod|END_ENTITY	C-reactive_protein , interleukin-6 , soluble tumor necrosis factor a receptor 2 and incident clinical depression .
25963492	0	C-reactive_protein	29,47	interleukin-6	49,62	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	serum_amyloid_A|amod|START_ENTITY serum_amyloid_A|amod|END_ENTITY	Evaluation of procalcitonin , C-reactive_protein , interleukin-6 _ serum_amyloid_A as diagnostic biomarkers of bacterial_infection in febrile patients .
26190096	0	C-reactive_protein	66,84	interleukin-6	101,114	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	parameters|nmod|START_ENTITY efficacy|nmod|parameters Comparison|nmod|efficacy Comparison|appos|levels levels|amod|END_ENTITY	Comparison of the efficacy of new leukocyte parameters with serum C-reactive_protein , procalcitonin , interleukin-6 levels in the diagnosis of neonatal_sepsis .
7627386	0	C-reactive_protein	55,73	interleukin-6	33,46	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	synthesis|amod|START_ENTITY reduces|dobj|synthesis reduces|iobj|induced induced|amod|END_ENTITY	Ranitidine reduces postoperative interleukin-6 induced C-reactive_protein synthesis .
8306367	0	C-reactive_protein	119,137	interleukin-6	56,69	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	induction|nmod|START_ENTITY I|dep|induction END_ENTITY|nmod|I	Immune function of patients receiving recombinant human interleukin-6 -LRB- IL-6 -RRB- in a phase I clinical study : induction of C-reactive_protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity .
8621622	0	C-reactive_protein	56,74	interleukin-6	83,96	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	gene|amod|START_ENTITY activation|nmod|gene participates|nmod|activation participates|advcl|END_ENTITY	STAT3 participates in transcriptional activation of the C-reactive_protein gene by interleukin-6 .
9645918	0	C-reactive_protein	81,99	interleukin-6	21,34	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Postoperative plasma interleukin-6 in patients with renal_cancer correlates with C-reactive_protein but not with total fibrinogen or with high molecular weight fibrinogen fraction .
9804463	0	C-reactive_protein	7,25	interleukin-6	65,78	C-reactive protein	interleukin-6	1401	3569	Gene	Gene	linked|nsubjpass|START_ENTITY linked|xcomp|backfiltration backfiltration|dobj|production production|amod|END_ENTITY	Plasma C-reactive_protein is linked to backfiltration associated interleukin-6 production .
10476751	0	C-reactive_protein	76,94	interleukin-8	61,74	C-reactive protein	interleukin-8	1401	3576	Gene	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Assessment of measuring circulating levels of interleukin-6 , interleukin-8 , C-reactive_protein , soluble Fc gamma receptor type III , and mannose-binding_protein in febrile children with cancer and neutropenia .
16123332	0	C-reactive_protein	31,49	interleukin-8	58,71	C-reactive protein	interleukin-8	1401	3576	Gene	Gene	symmetry|nmod|START_ENTITY Loss|nmod|symmetry induces|nsubj|Loss induces|dobj|secretion secretion|amod|END_ENTITY	Loss of pentameric symmetry in C-reactive_protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils .
16220077	0	C-reactive_protein	0,18	interleukin-8	28,41	C-reactive protein	interleukin-8	1401	3576	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|secretion secretion|amod|END_ENTITY	C-reactive_protein augments interleukin-8 secretion in human peripheral blood monocytes .
19781372	0	C-reactive_protein	0,18	interleukin-8	29,42	C-reactive protein	interleukin-8	1401	3576	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|amod|END_ENTITY	C-reactive_protein decreases interleukin-8 production in human endothelial progenitor cells by inhibition of p38 MAPK pathway .
20188089	0	C-reactive_protein	68,86	interleukin-8	13,26	C-reactive protein	interleukin-8	1401	3576	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin-8 gene expression and protein secretion by C-reactive_protein in ARPE-19 cells .
23124693	0	C-reactive_protein	32,50	interleukin-8	139,152	C-reactive protein	interleukin-8	1401	3576	Gene	Gene	levels|amod|START_ENTITY correlate|nsubj|levels correlate|nmod|index index|appos|rate rate|amod|END_ENTITY	Elevated serum high-sensitivity C-reactive_protein levels in fibromyalgia_syndrome patients correlate with body mass index , interleukin-6 , interleukin-8 , erythrocyte sedimentation rate .
11167745	0	C-reactive_protein	93,111	interleukin_6	113,126	C-reactive protein	interleukin 6	1401	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
16406714	0	C-reactive_protein	20,38	interleukin_6	125,138	C-reactive protein	interleukin 6	1401	3569	Gene	Gene	Unresponsiveness|nmod|START_ENTITY associated|nsubjpass|Unresponsiveness associated|nmod|END_ENTITY	Unresponsiveness of C-reactive_protein in the non-infectious inflammation of systemic_lupus_erythematosus is associated with interleukin_6 .
20834028	0	C-reactive_protein	0,18	interleukin_6	20,33	C-reactive protein	interleukin 6	1401	3569	Gene	Gene	role|advmod|START_ENTITY role|nsubj|END_ENTITY	C-reactive_protein , interleukin_6 , and N-terminal pro-brain natriuretic peptide following cardioversion of atrial_fibrillation : is there a role of biomarkers in arrhythmia recurrence ?
24026232	0	C-reactive_protein	127,145	interleukin_6	112,125	C-reactive protein	interleukin 6	1401	3569	Gene	Gene	count|amod|START_ENTITY count|amod|END_ENTITY	Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein , interleukin_6 , C-reactive_protein , white blood cell count , erythrocyte sedimentation rate and body temperature .
11167745	0	C-reactive_protein	93,111	interleukin_8	128,141	C-reactive protein	interleukin 8	1401	3576	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
15231900	0	C-reactive_protein	49,67	interleukin_8	15,28	C-reactive protein	interleukin 8	1401	3576	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Measurement of interleukin_8 in combination with C-reactive_protein reduced unnecessary antibiotic therapy in newborn infants : a multicenter , randomized , controlled trial .
11829320	0	C-reactive_protein	54,72	leptin	6,12	C-reactive protein	leptin	1401	3952	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|compound|END_ENTITY	Serum leptin levels in septic men correlate well with C-reactive_protein -LRB- CRP -RRB- and TNF-alpha but not with BMI .
24026232	0	C-reactive_protein	127,145	lipopolysaccharide-binding-protein	76,110	C-reactive protein	lipopolysaccharide-binding-protein	1401	3929	Gene	Gene	count|amod|START_ENTITY count|amod|END_ENTITY	Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein , interleukin_6 , C-reactive_protein , white blood cell count , erythrocyte sedimentation rate and body temperature .
18708524	0	C-reactive_protein	0,18	lipoprotein_lipase	39,57	C-reactive protein	lipoprotein lipase	1401	4023	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	C-reactive_protein enhances macrophage lipoprotein_lipase expression .
17362525	0	C-reactive_protein	14,32	macrophage_migration_inhibitory_factor	62,100	C-reactive protein	macrophage migration inhibitory factor	1401	4282	Gene	Gene	receptor|compound|START_ENTITY receptor|dep|END_ENTITY	Use of plasma C-reactive_protein , procalcitonin , neutrophils , macrophage_migration_inhibitory_factor , soluble urokinase-type plasminogen activator receptor , and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections : a prospective study .
23157807	0	C-reactive_protein	0,18	matrix_metalloproteinase-9	41,67	C-reactive protein	matrix metalloproteinase-9	1401	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	C-reactive_protein induces expression of matrix_metalloproteinase-9 : a possible link between inflammation and plaque_rupture .
15698590	0	C-reactive_protein	148,166	nuclear_factor-kappaB	85,106	C-reactive protein	nuclear factor-kappaB	1401	4790	Gene	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated END_ENTITY|nmod|cells	Fluvastatin inhibits the expression of tumor_necrosis_factor-alpha and activation of nuclear_factor-kappaB in human endothelial cells stimulated by C-reactive_protein .
17222729	0	C-reactive_protein	223,241	nuclear_factor_kappa-B	25,47	C-reactive protein	nuclear factor kappa-B	1401	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Persistent activation of nuclear_factor_kappa-B signaling pathway in patients with unstable_angina and elevated levels of C-reactive_protein evidence for a direct proinflammatory effect of azide and lipopolysaccharide-free C-reactive_protein on human monocytes via nuclear_factor_kappa-B activation .
10364245	0	C-reactive_protein	0,18	p38	56,59	C-reactive protein	p38	1401	1432	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	C-reactive_protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement .
18402807	0	C-reactive_protein	0,18	p38MAPK	91,98	C-reactive protein	p38MAPK	12944(Tax:10090)	26416(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	C-reactive_protein induces high-mobility_group_box-1 protein release through activation of p38MAPK in macrophage RAW264 .7 cells .
17949793	0	C-reactive_protein	0,18	plasminogen_activator_inhibitor-1	29,62	C-reactive protein	plasminogen activator inhibitor-1	1401	5054	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	C-reactive_protein increases plasminogen_activator_inhibitor-1 expression in human endothelial cells .
15839913	0	C-reactive_protein	0,18	prostate-specific_antigen	52,77	C-reactive protein	prostate-specific antigen	1401	354	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	C-reactive_protein is significantly associated with prostate-specific_antigen and metastatic_disease in prostate_cancer .
19201044	0	C-reactive_protein	0,18	receptor_for_advanced_glycation_end_products	52,96	C-reactive protein	receptor for advanced glycation end products	1401	177	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- up-regulates expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- and its inflammatory ligand EN-RAGE in THP-1 cells : inhibitory effects of atorvastatin .
16520718	0	C-reactive_protein	21,39	tissue_factor_pathway_inhibitor	58,89	C-reactive protein	tissue factor pathway inhibitor	1401	7035	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Inhibitory effect of C-reactive_protein on the release of tissue_factor_pathway_inhibitor from human endothelial cells : reversal by low molecular weight heparin .
20580035	0	C-reactive_protein	56,74	toll-like_receptor_4	85,105	C-reactive protein	toll-like receptor 4	1401	7099	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Adding exercise to rosuvastatin treatment : influence on C-reactive_protein , monocyte toll-like_receptor_4 expression , and inflammatory monocyte -LRB- CD14 + CD16 + -RRB- population .
2170518	0	C-reactive_protein	37,55	transforming_growth_factor-beta	70,101	C-reactive protein	transforming growth factor-beta	1401	7040	Gene	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of cytokine-induced human C-reactive_protein production by transforming_growth_factor-beta .
22883070	0	C-reactive_protein	12,30	transforming_growth_factor_b1	52,81	C-reactive protein	transforming growth factor b1	1401	7040	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of C-reactive_protein on the expression of transforming_growth_factor_b1 and receptors on human renal tubular epithelial cells -RSB- .
12553440	0	C-reactive_protein	0,18	transthyretin	22,35	C-reactive protein	transthyretin	1401	7276	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	C-reactive_protein to transthyretin ratio for the early diagnosis and follow-up of postoperative_infection .
19302556	0	C-reactive_protein	116,134	vascular_endothelial_growth_factor	6,40	C-reactive protein	vascular endothelial growth factor	1401	7422	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Serum vascular_endothelial_growth_factor in adult haematological patients with neutropenic_fever : a comparison with C-reactive_protein .
23270673	0	C-reactive_protein	85,103	visfatin	7,15	C-reactive protein	visfatin	1401	10135	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|END_ENTITY	Plasma visfatin , associated with a genetic polymorphism -1535 C > T , is correlated with C-reactive_protein in Chinese Han patients with traumatic_brain_injury .
18061561	0	C-terminal_Src_kinase	26,47	ASPP	11,15	C-terminal Src kinase	ASPP	41398(Tax:7227)	37422(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Drosophila ASPP regulates C-terminal_Src_kinase activity .
15277007	0	C-terminal_Src_kinase	18,39	Csk	41,44	C-terminal Src kinase	Csk	12988(Tax:10090)	12988(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of p50 C-terminal_Src_kinase -LRB- Csk -RRB- in mouse testis .
16439366	0	C-terminal_Src_kinase	90,111	Csk	113,116	C-terminal Src kinase	Csk	1445	1445	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase , C-terminal_Src_kinase -LRB- Csk -RRB- .
18268019	0	C-terminal_Src_kinase	25,46	Csk	48,51	C-terminal Src kinase	Csk	1445	1445	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Translational control of C-terminal_Src_kinase -LRB- Csk -RRB- expression by PRL3 phosphatase .
9890993	0	C-terminal_Src_kinase	38,59	Csk	61,64	C-terminal Src kinase	Csk	12988(Tax:10090)	12988(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Adenovirus-mediated overexpression of C-terminal_Src_kinase -LRB- Csk -RRB- in type I astrocytes interferes with cell spreading and attachment to fibronectin .
18268019	0	C-terminal_Src_kinase	25,46	PRL3	67,71	C-terminal Src kinase	PRL3	1445	11156	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Translational control of C-terminal_Src_kinase -LRB- Csk -RRB- expression by PRL3 phosphatase .
11882594	0	C-terminal_Src_kinase	130,151	Src	34,37	C-terminal Src kinase	Src	315707(Tax:10116)	83805(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY associated|nmod|activity associated|nsubjpass|END_ENTITY	Increased angiotensin_II-mediated Src signaling via epidermal_growth_factor_receptor transactivation is associated with decreased C-terminal_Src_kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats .
24648518	0	C-terminal_Src_kinase	0,21	eEF2	88,92	C-terminal Src kinase	eEF2	1445	1938	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	C-terminal_Src_kinase -LRB- Csk -RRB- - mediated phosphorylation of eukaryotic_elongation_factor_2 -LRB- eEF2 -RRB- promotes proteolytic cleavage and nuclear translocation of eEF2 .
10026153	0	C-terminal_Src_kinase	0,21	insulin-like_growth_factor-I_receptor	56,93	C-terminal Src kinase	insulin-like growth factor-I receptor	12988(Tax:10090)	16001(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	C-terminal_Src_kinase associates with ligand-stimulated insulin-like_growth_factor-I_receptor .
27015736	0	C-terminal_agrin_fragment	16,41	CAF	43,46	C-terminal agrin fragment	CAF	8850	8850	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of C-terminal_agrin_fragment -LRB- CAF -RRB- are associated with sarcopenia in older multimorbid community-dwellers : Results from the ilSIRENTE study .
9479502	0	C-terminal_binding_protein	8,34	CTBP1	65,70	C-terminal binding protein	CTBP1	1488	1487	Gene	Gene	related|nsubj|START_ENTITY related|nmod|END_ENTITY	A novel C-terminal_binding_protein -LRB- CTBP2 -RRB- is closely related to CTBP1 , an adenovirus E1A-binding protein , and maps to human chromosome 21q21 .3 .
23410750	0	C-terminal_binding_protein_2	50,78	C-terminus_of_Hsc70-interacting_protein	0,39	C-terminal binding protein 2	C-terminus of Hsc70-interacting protein	1488	358	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	C-terminus_of_Hsc70-interacting_protein regulates C-terminal_binding_protein_2 and the expression of its target genes .
19441079	0	C-terminal_peptide	63,81	Regulator_of_differentiation_1	0,30	C-terminal peptide	Regulator of differentiation 1	79718	9991	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Regulator_of_differentiation_1 -LRB- ROD1 -RRB- binds to the amphipathic C-terminal_peptide of thrombospondin-4 and is involved in its mitogenic activity .
14672664	0	C-terminal_region	33,50	Ku86	54,58	C-terminal region	Ku86	799	7520	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The 3D solution structure of the C-terminal_region of Ku86 -LRB- Ku86CTR -RRB- .
23410750	0	C-terminus_of_Hsc70-interacting_protein	0,39	C-terminal_binding_protein_2	50,78	C-terminus of Hsc70-interacting protein	C-terminal binding protein 2	358	1488	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	C-terminus_of_Hsc70-interacting_protein regulates C-terminal_binding_protein_2 and the expression of its target genes .
25447402	0	C-type_lectin-like_domain_family-16A	19,55	CLEC16A	57,64	C-type lectin-like domain family-16A	CLEC16A	23274	23274	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the C-type_lectin-like_domain_family-16A -LRB- CLEC16A -RRB- gene polymorphisms with acute_coronary_syndrome in Mexican patients .
18241264	0	C-type_lectin_receptor	89,111	Toll-like_receptor_2	0,20	C-type lectin receptor	Toll-like receptor 2	338339	7097	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Toll-like_receptor_2 is highly expressed in lesions of acne inversa and colocalizes with C-type_lectin_receptor .
8117275	0	C-type_natriuretic_peptide	13,39	CNP	91,94	C-type natriuretic peptide	CNP	4880	4880	Gene	Gene	Detection|nmod|START_ENTITY END_ENTITY|nsubj|Detection	Detection of C-type_natriuretic_peptide in human circulation and marked increase of plasma CNP level in septic_shock patients .
9089468	0	C-type_natriuretic_peptide	13,39	CNP	41,44	C-type natriuretic peptide	CNP	4880	4880	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of C-type_natriuretic_peptide -LRB- CNP -RRB- by immortalized LHRH cells .
2383278	0	C-type_natriuretic_peptide	30,56	CNP-53	58,64	C-type natriuretic peptide	CNP-53	4880	4880	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	N-terminally extended form of C-type_natriuretic_peptide -LRB- CNP-53 -RRB- identified in porcine brain .
18848850	0	C-type_natriuretic_peptide	14,40	NPR-B	61,66	C-type natriuretic peptide	NPR-B	4880	4882	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of C-type_natriuretic_peptide and of its receptor NPR-B in normal and failing heart .
20595933	0	C-type_natriuretic_peptide	11,37	NPR-B	0,5	C-type natriuretic peptide	NPR-B	4880	230103(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	NPR-B , the C-type_natriuretic_peptide specific receptor , is the predominant biological receptor in mouse and pig myocardial tissue .
25012822	0	C-type_natriuretic_peptide	55,81	NPR-B	92,97	C-type natriuretic peptide	NPR-B	4880	230103(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Mutant phenotype analysis suggests potential roles for C-type_natriuretic_peptide receptor -LRB- NPR-B -RRB- in male mouse fertility .
24934313	0	C-type_natriuretic_peptide	37,63	TGF-b	81,86	C-type natriuretic peptide	TGF-b	4880	7040	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Matrilin-3 as a putative effector of C-type_natriuretic_peptide signaling during TGF-b induced chondrogenic differentiation of mesenchymal stem cells .
20721606	0	C-type_natriuretic_peptide	25,51	TGF-b1	100,106	C-type natriuretic peptide	TGF-b1	4880	7040	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Dose dependent effect of C-type_natriuretic_peptide signaling in glycosaminoglycan synthesis during TGF-b1 induced chondrogenic differentiation of mesenchymal stem cells .
11984695	0	C-type_natriuretic_peptide	0,26	guanylate_cyclase_B	27,46	C-type natriuretic peptide	guanylate cyclase B	4880	4882	Gene	Gene	START_ENTITY|dep|system system|compound|END_ENTITY	C-type_natriuretic_peptide / guanylate_cyclase_B system in ATDC5 cells , a chondrogenic cell line .
22714108	0	C-type_natriuretic_peptide-3	15,43	TGF-b1	120,126	C-type natriuretic peptide-3	TGF-b1	419487(Tax:9031)	100873157	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Implication of C-type_natriuretic_peptide-3 signaling in glycosaminoglycan synthesis and chondrocyte hypertrophy during TGF-b1 induced chondrogenic differentiation of chicken bone marrow-derived mesenchymal stem cells .
12970736	0	C/EBP	34,39	Bcl-2	14,19	C/EBP	Bcl-2	1050	596	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of Bcl-2 expression by C/EBP in t -LRB- 14 ; 18 -RRB- lymphoma cells .
12200447	0	C/EBP	11,16	CBF1	26,30	C/EBP	CBF1	1050	3516	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of C/EBP and RBP -LRB- CBF1 -RRB- to overlapping sites regulates interleukin-6 gene expression .
21076392	0	C/EBP	22,27	FBXW7	39,44	C/EBP	FBXW7	1050	55294	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	The tumour suppressor C/EBP inhibits FBXW7 expression and promotes mammary tumour metastasis .
11012671	0	C/EBP	40,45	Gadd45gamma	14,25	C/EBP	Gadd45gamma	1050	10912	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Gadd45gamma expression by C/EBP .
26740594	0	C/EBP	37,42	Growth_Arrest_Specific-1	0,24	C/EBP	Growth Arrest Specific-1	12606(Tax:10090)	14451(Tax:10090)	Gene	Gene	Gene|compound|START_ENTITY Gene|nsubj|END_ENTITY	Growth_Arrest_Specific-1 -LRB- GAS1 -RRB- Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice .
12219016	0	C/EBP	50,55	Interleukin-10	0,14	C/EBP	Interleukin-10	1050	3586	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells .
2253878	0	C/EBP	27,32	LAP	0,3	C/EBP	LAP	1050	7939	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	LAP , a novel member of the C/EBP gene family , encodes a liver-enriched_transcriptional_activator_protein .
26017382	0	C/EBP	79,84	LIP	64,67	C/EBP	LIP	1050	23049	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	Degradation of polyomavirus_JC T-antigen by stress involves the LIP isoform of C/EBP .
8999951	0	C/EBP	42,47	Oct-1	0,5	C/EBP	Oct-1	1050	5451	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Oct-1 and CCAAT/enhancer-binding _ protein -LRB- C/EBP -RRB- bind to overlapping elements within the interleukin-8 promoter .
19926610	0	C/EBP	10,15	Per2	0,4	C/EBP	Per2	1050	8864	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Per2 is a C/EBP target gene implicated in myeloid_leukemia .
25035816	0	C/EBP	79,84	Secretory_Phospholipase_A2	44,70	C/EBP	Secretory Phospholipase A2	25301(Tax:10116)	29692(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Gene Gene|compound|END_ENTITY	Transcriptional Regulation of the Group IIA Secretory_Phospholipase_A2 Gene by C/EBP in Rat liver and its Relationship to Hepatic Gluconeogenesis during Sepsis .
23534754	0	C/EBP	80,85	Tax	0,3	C/EBP	Tax	1050	6900	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Tax is involved in up-regulation of HMGB1 expression levels by interaction with C/EBP .
21666710	0	C/EBP	0,5	VEGF-C	19,25	C/EBP	VEGF-C	12606(Tax:10090)	22341(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|autocrine autocrine|nsubj|END_ENTITY	C/EBP - regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung_cancer through HIF-1a .
10598019	0	C/EBP	68,73	gelatin-binding_protein_28	14,40	C/EBP	gelatin-binding protein 28	1050	9370	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of gelatin-binding_protein_28 -LRB- GBP28 -RRB- gene expression by C/EBP .
21741997	0	C/EBP	0,5	neutrophil_gelatinase-associated_lipocalin	20,62	C/EBP	neutrophil gelatinase-associated lipocalin	1050	3934	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	C/EBP targets to neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- as a repressor for metastasis of MDA-MB-231 cells .
23881867	0	C/EBP-a	25,32	IL-13	48,53	C/EBP-a	IL-13	1050	3596	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Reciprocal modulation of C/EBP-a and C/EBP-b by IL-13 in activated microglia prevents neuronal_death .
22495929	0	C/EBP-b	34,41	Akt	54,57	C/EBP-b	Akt	1051	207	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Negative regulation of miR-145 by C/EBP-b through the Akt pathway in cancer cells .
26868909	0	C/EBP-b	21,28	PHLPP2	66,72	C/EBP-b	PHLPP2	1051	23035	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Transcription factor C/EBP-b induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells .
24472318	0	C/EBP-b	21,28	interleukin-6	95,108	C/EBP-b	interleukin-6	1051	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Transcription factor C/EBP-b mediates downregulation of dipeptidyl-peptidase_III expression by interleukin-6 in human glioblastoma cells .
11854037	0	C/EBP-beta	19,29	IL-1beta	0,8	C/EBP-beta	IL-1beta	1051	3553	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	IL-1beta activates C/EBP-beta and delta in human enterocytes through a mitogen-activated protein kinase signaling pathway .
15389813	0	C/EBP-beta	96,106	NFkappaB	47,55	C/EBP-beta	NFkappaB	1051	4790	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta -LRB- C/EBP-beta -RRB- regulate the IL-6 promoter in autocrine human prostate_cancer cells .
25173154	0	C/EBP-beta	50,60	Tumor_necrosis_factor-alpha	0,27	C/EBP-beta	Tumor necrosis factor-alpha	1051	7124	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces expression of C/EBP-beta in primary afferent neurons following_nerve_injury .
11834703	0	C/EBP-beta	0,10	iNOS	20,24	C/EBP-beta	iNOS	24253(Tax:10116)	24599(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	C/EBP-beta mediates iNOS induction by hypoxia in rat pulmonary microvascular smooth muscle cells .
21664907	0	C/EBPa	46,52	Apoptosis-inducing_factor	0,25	C/EBPa	Apoptosis-inducing factor	1050	9131	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Apoptosis-inducing_factor is a target gene of C/EBPa and participates in adipocyte differentiation .
22797303	0	C/EBPa	86,92	CDK1	10,14	C/EBPa	CDK1	1050	983	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Targeting CDK1 promotes FLT3-activated acute_myeloid_leukemia differentiation through C/EBPa .
23884858	0	C/EBPa	13,19	COP1	0,4	C/EBPa	COP1	1050	64326	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	COP1 targets C/EBPa for degradation and induces acute_myeloid_leukemia via Trib1 .
22902925	0	C/EBPa	72,78	DACH1	58,63	C/EBPa	DACH1	1050	1602	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
20889924	0	C/EBPa	0,6	E2F3	38,42	C/EBPa	E2F3	1050	1871	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	C/EBPa regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations .
23340802	0	C/EBPa	0,6	FLT3	24,28	C/EBPa	FLT3	1050	2322	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	C/EBPa and MYB regulate FLT3 expression in AML .
23639777	0	C/EBPa	32,38	HDAC3	0,5	C/EBPa	HDAC3	24252(Tax:10116)	84578(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HDAC3 interacts with sumoylated C/EBPa to negatively regulate the LXRa expression in rat hepatocytes .
26704017	0	C/EBPa	0,6	HDAC3	60,65	C/EBPa	HDAC3	1050	8841	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|acl|recruiting recruiting|dobj|END_ENTITY	C/EBPa negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular_carcinoma cells .
22902925	0	C/EBPa	72,78	HOXA9	14,19	C/EBPa	HOXA9	1050	3205	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
25236377	0	C/EBPa	14,20	IRF8	0,4	C/EBPa	IRF8	1050	3394	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	IRF8 inhibits C/EBPa activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils .
22902925	0	C/EBPa	72,78	MLL-AF9	115,122	C/EBPa	MLL-AF9	1050	4297	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
26704017	0	C/EBPa	0,6	SIRT7	28,33	C/EBPa	SIRT7	1050	51547	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	C/EBPa negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular_carcinoma cells .
21503969	0	C/EBPa	16,22	TCERG1	0,6	C/EBPa	TCERG1	1050	10915	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	TCERG1 inhibits C/EBPa through a mechanism that does not involve sequestration of C/EBPa at pericentromeric heterochromatin .
21503969	0	C/EBPa	82,88	TCERG1	0,6	C/EBPa	TCERG1	1050	10915	Gene	Gene	sequestration|nmod|START_ENTITY involve|dobj|sequestration mechanism|acl:relcl|involve inhibits|nmod|mechanism inhibits|nsubj|END_ENTITY	TCERG1 inhibits C/EBPa through a mechanism that does not involve sequestration of C/EBPa at pericentromeric heterochromatin .
26264132	0	C/EBPa	110,116	TCERG1	39,45	C/EBPa	TCERG1	1050	10915	Gene	Gene	Activity|nmod|START_ENTITY Inhibition|nmod|Activity Required|nmod|Inhibition Required|nsubjpass|Domain Domain|nmod|END_ENTITY	The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBPa .
22024156	0	C/EBPa	0,6	TNFa	89,93	C/EBPa	TNFa	1050	7124	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	C/EBPa mediates the transcriptional suppression of human calreticulin gene expression by TNFa .
21687683	0	C/EBPa	94,100	cathepsin_L	56,67	C/EBPa	cathepsin L	1050	1514	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Down regulation of a matrix degrading cysteine protease cathepsin_L , by acetaldehyde : role of C/EBPa .
23831605	0	C/EBPa	24,30	p42	12,15	C/EBPa	p42	1050	23552	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	Lack of the p42 form of C/EBPa leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors .
11753385	0	C/EBPalpha	19,29	BCR-ABL	0,7	C/EBPalpha	BCR-ABL	1050	25	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP_E2 .
10982846	0	C/EBPalpha	83,93	C/EBPbeta	0,9	C/EBPalpha	C/EBPbeta	12606(Tax:10090)	12608(Tax:10090)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	C/EBPbeta , when expressed from the C/ebpalpha gene locus , can functionally replace C/EBPalpha in liver but not in adipose tissue .
19581927	0	C/EBPalpha	0,10	C/EBPbeta	48,57	C/EBPalpha	C/EBPbeta	1050	1051	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	C/EBPalpha expression is partially regulated by C/EBPbeta in response to DNA damage and C/EBPalpha-deficient fibroblasts display an impaired G1 checkpoint .
12406909	0	C/EBPalpha	13,23	CD34	85,89	C/EBPalpha	CD34	1050	947	Gene	Gene	activity|compound|START_ENTITY Induction|nmod|activity alters|nsubj|Induction alters|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34 + cells .
17475913	0	C/EBPalpha	18,28	CD34	41,45	C/EBPalpha	CD34	1050	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Reintroduction of C/EBPalpha in leukemic CD34 + stem/progenitor cells impairs self-renewal and partially restores myelopoiesis .
12242300	0	C/EBPalpha	28,38	Calreticulin	0,12	C/EBPalpha	Calreticulin	1050	811	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins .
9421462	0	C/EBPalpha	84,94	GLUT4	60,65	C/EBPalpha	GLUT4	1050	6517	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes .
18622015	0	C/EBPalpha	22,32	HDAC1	0,5	C/EBPalpha	HDAC1	12606(Tax:10090)	433759(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice .
12522006	0	C/EBPalpha	22,32	JunB	49,53	C/EBPalpha	JunB	1050	3726	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region .
17094771	0	C/EBPalpha	130,140	PEPCK	53,58	C/EBPalpha	PEPCK	1050	5106	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EBPalpha .
11782441	0	C/EBPalpha	0,10	PPARgamma	40,49	C/EBPalpha	PPARgamma	1050	5468	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	C/EBPalpha induces adipogenesis through PPARgamma : a unified pathway .
9421462	0	C/EBPalpha	84,94	PPARgamma	0,9	C/EBPalpha	PPARgamma	1050	5468	Gene	Gene	absence|nmod|START_ENTITY GLUT4|nmod|absence induces|dobj|GLUT4 induces|nsubj|END_ENTITY	PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes .
20157332	0	C/EBPalpha	0,10	SIRT1	21,26	C/EBPalpha	SIRT1	1050	23411	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	C/EBPalpha regulates SIRT1 expression during adipogenesis .
10373535	0	C/EBPalpha	32,42	Sp1	21,24	C/EBPalpha	Sp1	1050	6667	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Repressive effect of Sp1 on the C/EBPalpha gene promoter : role in adipocyte differentiation .
17097562	0	C/EBPalpha	31,41	Tribbles_homolog_2	0,18	C/EBPalpha	Tribbles homolog 2	1050	28951	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	Tribbles_homolog_2 inactivates C/EBPalpha and causes acute_myelogenous_leukemia .
15919796	0	C/EBPalpha	0,10	adiponectin	27,38	C/EBPalpha	adiponectin	1050	9370	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer .
12446786	0	C/EBPalpha	59,69	c-Jun	18,23	C/EBPalpha	c-Jun	12606(Tax:10090)	16476(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment .
12879022	0	C/EBPalpha	62,72	c-Jun	9,14	C/EBPalpha	c-Jun	1050	3725	Gene	Gene	binding|compound|START_ENTITY inhibits|dobj|binding inhibits|nsubj|expression expression|amod|END_ENTITY	Elevated c-Jun expression in acute_myeloid_leukemias inhibits C/EBPalpha DNA binding via leucine zipper domain interaction .
12105198	0	C/EBPalpha	0,10	calpain_3	63,72	C/EBPalpha	calpain 3	12606(Tax:10090)	12335(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	C/EBPalpha is required for proteolytic cleavage of cyclin_A by calpain_3 in myeloid precursor cells .
8668205	0	C/EBPalpha	0,10	gadd45	59,65	C/EBPalpha	gadd45	1050	1647	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	C/EBPalpha regulation of the growth-arrest-associated gene gadd45 .
17627282	0	C/EBPalpha	33,43	insulin	12,19	C/EBPalpha	insulin	1050	3630	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development .
14712233	0	C/EBPalpha	60,70	osteopontin	36,47	C/EBPalpha	osteopontin	1050	6696	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Transcriptional regulation of human osteopontin promoter by C/EBPalpha and AML-1 in metastatic_cancer cells .
15752068	0	C/EBPalpha	0,10	triacylglycerol_hydrolase	42,67	C/EBPalpha	triacylglycerol hydrolase	12606(Tax:10090)	104158(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	C/EBPalpha activates the transcription of triacylglycerol_hydrolase in 3T3-L1 adipocytes .
25779641	0	C/EBPb	0,6	CEBPB	8,13	C/EBPb	CEBPB	1051	1051	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	C/EBPb -LRB- CEBPB -RRB- protein binding to the C/EBP CRE DNA 8-mer TTGC GTCA is inhibited by 5hmC and enhanced by 5mC , 5fC , and 5caC in the CG dinucleotide .
24043631	0	C/EBPb	35,41	ERK	29,32	C/EBPb	ERK	1051	5594	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	MUC1-C oncoprotein activates ERK > C/EBPb signaling and induction of aldehyde_dehydrogenase_1A1 in breast_cancer cells .
21167261	0	C/EBPb	62,68	Foxa1	30,35	C/EBPb	Foxa1	12608(Tax:10090)	15375(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Forkhead transcription factor Foxa1 is a novel target gene of C/EBPb and suppresses the early phase of adipogenesis .
21353395	0	C/EBPb	109,115	GADD45b	57,64	C/EBPb	GADD45b	12608(Tax:10090)	17873(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Senescence of chondrocytes in aging articular cartilage : GADD45b mediates p21 expression in association with C/EBPb in senescence-accelerated mice .
26896926	0	C/EBPb	34,40	GADD45b	126,133	C/EBPb	GADD45b	1051	4616	Gene	Gene	binding_protein_b|appos|START_ENTITY regulates|nsubj|binding_protein_b regulates|dobj|transcription transcription|appos|END_ENTITY	CCAAT/enhancer _ binding_protein_b -LRB- C/EBPb -RRB- regulates the transcription of growth_arrest and DNA damage-inducible protein 45 b -LRB- GADD45b -RRB- in articular chondrocytes .
23782693	0	C/EBPb	73,79	Hipk2	132,137	C/EBPb	Hipk2	12608(Tax:10090)	15258(Tax:10090)	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction and cooperation of the CCAAT-box enhancer-binding protein b -LRB- C/EBPb -RRB- with the homeodomain-interacting_protein_kinase_2 -LRB- Hipk2 -RRB- .
26566865	0	C/EBPb	25,31	Hmgn1	0,5	C/EBPb	Hmgn1	12608(Tax:10090)	15312(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Hmgn1 acts downstream of C/EBPb to regulate the decidualization of uterine stromal cells in mice .
22260630	0	C/EBPb	125,131	IL-1b	61,66	C/EBPb	IL-1b	1051	3553	Gene	Gene	role|nmod|START_ENTITY requires|nmod|role requires|nsubj|Regulation Regulation|nmod|prostaglandin_E prostaglandin_E|amod|synthase-1 synthase-1|nmod|END_ENTITY	Regulation of human microsomal prostaglandin_E synthase-1 by IL-1b requires a distal enhancer element with a unique role for C/EBPb .
25329476	0	C/EBPb	49,55	IL-1b	29,34	C/EBPb	IL-1b	1051	3553	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Allele-Specific Induction of IL-1b Expression by C/EBPb and PU .1 Contributes to Increased Tuberculosis Susceptibility .
21612443	0	C/EBPb	113,119	Neutrophil_gelatinase-associated_lipocalin	0,42	C/EBPb	Neutrophil gelatinase-associated lipocalin	1051	3934	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	Neutrophil_gelatinase-associated_lipocalin in gastric_carcinoma cells and its induction by TPA are controlled by C/EBPb .
25403356	0	C/EBPb	0,6	P2X7_receptor	17,30	C/EBPb	P2X7 receptor	1051	5027	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	C/EBPb regulates P2X7_receptor expression in response to glucose challenge in intestinal epithelial cells .
25110868	0	C/EBPb	65,71	S100A12	30,37	C/EBPb	S100A12	397360(Tax:9823)	100301483(Tax:9823)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The inflammation-related gene S100A12 is positively regulated by C/EBPb and AP-1 in pigs .
25784653	0	C/EBPb	76,82	miR-191	0,7	C/EBPb	miR-191	1051	406966	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-191 promotes tumorigenesis of human colorectal_cancer through targeting C/EBPb .
23162623	0	C/EBPb	71,77	neutrophil_gelatinase-associated_lipocalin	14,56	C/EBPb	neutrophil gelatinase-associated lipocalin	1051	3934	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of neutrophil_gelatinase-associated_lipocalin expression by C/EBPb in lung_carcinoma cells .
25878769	0	C/EBPb	109,115	transforming_growth_factor-beta	63,94	C/EBPb	transforming growth factor-beta	1051	7040	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Retinoic_acid promotes myogenesis in myoblasts by antagonizing transforming_growth_factor-beta signaling via C/EBPb .
25878769	0	C/EBPb	109,115	transforming_growth_factor-beta	63,94	C/EBPb	transforming growth factor-beta	1051	7040	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Retinoic_acid promotes myogenesis in myoblasts by antagonizing transforming_growth_factor-beta signaling via C/EBPb .
17583490	0	C/EBPbeta	91,100	17beta-hydroxysteroid_dehydrogenase	47,82	C/EBPbeta	17beta-hydroxysteroid dehydrogenase	1051	7923	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the human type 8 17beta-hydroxysteroid_dehydrogenase gene by C/EBPbeta .
14522018	0	C/EBPbeta	97,106	C-reactive_protein	36,54	C/EBPbeta	C-reactive protein	1051	1401	Gene	Gene	binding|nmod|START_ENTITY facilitating|dobj|binding enhances|advcl|facilitating enhances|dobj|expression expression|amod|END_ENTITY	Transcription factor c-Rel enhances C-reactive_protein expression by facilitating the binding of C/EBPbeta to the promoter .
17335903	0	C/EBPbeta	30,39	C-reactive_protein	74,92	C/EBPbeta	C-reactive protein	1051	1401	Gene	Gene	C-Rel|nmod|START_ENTITY interaction|nmod|C-Rel enhances|nsubj|interaction enhances|xcomp|binding binding|nmod|promoter promoter|amod|END_ENTITY	The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive_protein gene promoter .
17335903	0	C/EBPbeta	49,58	C-reactive_protein	74,92	C/EBPbeta	C-reactive protein	1051	1401	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	The interaction of C-Rel with C/EBPbeta enhances C/EBPbeta binding to the C-reactive_protein gene promoter .
18684932	0	C/EBPbeta	11,20	C-reactive_protein	28,46	C/EBPbeta	C-reactive protein	1051	1401	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Binding of C/EBPbeta to the C-reactive_protein -LRB- CRP -RRB- promoter in Hep3B cells is associated with transcription of CRP mRNA .
10982846	0	C/EBPbeta	0,9	C/EBPalpha	83,93	C/EBPbeta	C/EBPalpha	12608(Tax:10090)	12606(Tax:10090)	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	C/EBPbeta , when expressed from the C/ebpalpha gene locus , can functionally replace C/EBPalpha in liver but not in adipose tissue .
19581927	0	C/EBPbeta	48,57	C/EBPalpha	0,10	C/EBPbeta	C/EBPalpha	1051	1050	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	C/EBPalpha expression is partially regulated by C/EBPbeta in response to DNA damage and C/EBPalpha-deficient fibroblasts display an impaired G1 checkpoint .
9405372	0	C/EBPbeta	56,65	C/EBPdelta	73,83	C/EBPbeta	C/EBPdelta	12608(Tax:10090)	12609(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene .
20385540	0	C/EBPbeta	133,142	CDH3	146,150	C/EBPbeta	CDH3	1051	1001	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	ICI_182 ,780 induces P-cadherin overexpression in breast_cancer cells through chromatin remodelling at the promoter level : a role for C/EBPbeta in CDH3 gene activation .
15598659	0	C/EBPbeta	104,113	Col1a1	0,6	C/EBPbeta	Col1a1	12608(Tax:10090)	12842(Tax:10090)	Gene	Gene	isoform|compound|START_ENTITY expression|appos|isoform expression|amod|END_ENTITY	Col1a1 promoter-targeted expression of p20 CCAAT_enhancer-binding_protein beta -LRB- C/EBPbeta -RRB- , a truncated C/EBPbeta isoform , causes osteopenia in transgenic_mice .
15598659	0	C/EBPbeta	80,89	Col1a1	0,6	C/EBPbeta	Col1a1	12608(Tax:10090)	12842(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Col1a1 promoter-targeted expression of p20 CCAAT_enhancer-binding_protein beta -LRB- C/EBPbeta -RRB- , a truncated C/EBPbeta isoform , causes osteopenia in transgenic_mice .
12574125	0	C/EBPbeta	84,93	HDAC1	57,62	C/EBPbeta	HDAC1	12608(Tax:10090)	433759(Tax:10090)	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta .
11009091	0	C/EBPbeta	0,9	IL-4	19,23	C/EBPbeta	IL-4	12608(Tax:10090)	16189(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	C/EBPbeta enhances IL-4 but impairs IL-2 and IFN-gamma induction in T cells .
16850160	0	C/EBPbeta	0,9	MnSOD	32,37	C/EBPbeta	MnSOD	1051	6648	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	C/EBPbeta regulates TNF induced MnSOD expression and protection against apoptosis .
11684016	0	C/EBPbeta	0,9	RSK	29,32	C/EBPbeta	RSK	12608(Tax:10090)	20111(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival .
19014341	0	C/EBPbeta	53,62	TGF-beta1	31,40	C/EBPbeta	TGF-beta1	1051	7040	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Evidence for activation of the TGF-beta1 promoter by C/EBPbeta and its modulation by Smads .
11711437	0	C/EBPbeta	40,49	TIF1beta	0,8	C/EBPbeta	TIF1beta	1051	10155	Gene	Gene	coactivator|nmod|START_ENTITY END_ENTITY|nmod|coactivator	TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937 .
9742105	0	C/EBPbeta	57,66	TIF1beta	12,20	C/EBPbeta	TIF1beta	1051	10155	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid_receptor to induce alpha1-acid glycoprotein gene expression .
16850160	0	C/EBPbeta	0,9	TNF	20,23	C/EBPbeta	TNF	1051	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	C/EBPbeta regulates TNF induced MnSOD expression and protection against apoptosis .
10930293	0	C/EBPbeta	70,79	TNF-alpha	14,23	C/EBPbeta	TNF-alpha	1051	7124	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of TNF-alpha expression in normal macrophages : the role of C/EBPbeta .
15367685	0	C/EBPbeta	19,28	extracellular_signal-regulated_kinase	44,81	C/EBPbeta	extracellular signal-regulated kinase	12608(Tax:10090)	26413(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of C/EBPbeta at a consensus extracellular_signal-regulated_kinase / glycogen synthase kinase 3 site is required for the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes .
16331681	0	C/EBPbeta	115,124	interferon-gamma	42,58	C/EBPbeta	interferon-gamma	1051	3458	Gene	Gene	binding_protein_beta|appos|START_ENTITY role|nmod|binding_protein_beta Inhibition|dep|role Inhibition|nmod|expression expression|nmod|END_ENTITY	Inhibition of collagen gene expression by interferon-gamma : novel role of the CCAAT/enhancer _ binding_protein_beta -LRB- C/EBPbeta -RRB- .
19353522	0	C/EBPbeta	0,9	interferon-gamma	66,82	C/EBPbeta	interferon-gamma	1051	3458	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	C/EBPbeta mediates synergistic upregulation of gene expression by interferon-gamma and tumor_necrosis_factor-alpha in bone marrow-derived mesenchymal stem cells .
18636078	0	C/EBPbeta	0,9	p53	20,23	C/EBPbeta	p53	12608(Tax:10090)	22060(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	C/EBPbeta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19 -LRB- Arf -RRB- .
9405372	0	C/EBPdelta	73,83	C/EBPbeta	56,65	C/EBPdelta	C/EBPbeta	12609(Tax:10090)	12608(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene .
17965828	0	C/EBPdelta	69,79	Sp1	32,35	C/EBPdelta	Sp1	12609(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of transcriptional factors Sp1 , c-Rel , and c-Jun in LPS-induced C/EBPdelta gene expression of mouse macrophages .
17347301	0	C/EBPepsilon	86,98	ATF4	0,4	C/EBPepsilon	ATF4	1053	468	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha .
11597733	0	C/EBPepsilon	87,99	CCAAT_enhancer_binding_protein_epsilon	47,85	C/EBPepsilon	CCAAT enhancer binding protein epsilon	1053	1053	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	DNase I hypersensitivity analysis of the human CCAAT_enhancer_binding_protein_epsilon -LRB- C/EBPepsilon -RRB- gene .
25886310	0	C/ebpa	42,48	DNA_methyltransferase_1	0,23	C/ebpa	DNA methyltransferase 1	140815(Tax:7955)	30430(Tax:7955)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	DNA_methyltransferase_1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish .
15781109	0	C1-INH	53,59	C1-esterase	30,41	C1-INH	C1-esterase	710;3183	716	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The critical concentration of C1-esterase inhibitor -LRB- C1-INH -RRB- in human serum preventing auto-activation of the first component of complement -LRB- C1 -RRB- .
15781109	0	C1-esterase	30,41	C1-INH	53,59	C1-esterase	C1-INH	716	710;3183	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	The critical concentration of C1-esterase inhibitor -LRB- C1-INH -RRB- in human serum preventing auto-activation of the first component of complement -LRB- C1 -RRB- .
10072448	0	C10	83,86	a_beta	66,72	C10	a beta	3226	351	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Presence of P210bcrabl is associated with decreased expression of a_beta chemokine C10 gene in a P210bcrabl-positive myeloid_leukemia cell line .
24014582	0	C10orf2	68,75	PEO1	77,81	C10orf2	PEO1	56652	56652	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Progressive external ophthalmoplegia -LRB- PEO -RRB- due to a mutation in the C10orf2 -LRB- PEO1 -RRB- gene mimicking a myasthenic_crisis .
20377893	0	C12orf10	39,47	MYG1	33,37	C12orf10	MYG1	60314	60314	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Promoter polymorphism -119 C/G in MYG1 -LRB- C12orf10 -RRB- gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entrance of Myg1 .
8866660	0	C1300	67,72	S-adenosyl-L-homocysteine_hydrolase	28,63	C1300	S-adenosyl-L-homocysteine hydrolase	1034995(Tax:199310)	269378(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Resistance to inhibitors of S-adenosyl-L-homocysteine_hydrolase in C1300 murine neuroblastoma_tumor cells is associated with increased methionine adenosyltransferase activity .
15566486	0	C14orf4	81,88	chromosome_14_open_reading_frame_4	45,79	C14orf4	chromosome 14 open reading frame 4	64207	64207	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the bovine homologue of the human chromosome_14_open_reading_frame_4 -LRB- C14orf4 -RRB- gene to BTA10q36 .
9583684	0	C15	16,19	EGFR	96,100	C15	EGFR	51316	1956	Gene	Gene	protein|compound|START_ENTITY confers|nsubj|protein confers|dobj|activation activation|nmod|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
9583684	0	C15	16,19	LMP1	20,24	C15	LMP1	51316	9260	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
9583684	0	C15	16,19	NF-kappa_B	64,74	C15	NF-kappa B	51316	4790	Gene	Gene	protein|compound|START_ENTITY confers|nsubj|protein confers|dobj|activation activation|nmod|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
17610557	0	C1584	0,5	ADAMTS13	72,80	C1584	ADAMTS13	1035340(Tax:199310)	11093	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	C1584 in von_Willebrand_factor is necessary for enhanced proteolysis by ADAMTS13 in vitro .
26735137	0	C19orf66	27,35	RyDEN	20,25	C19orf66	RyDEN	55337	55337	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of RyDEN -LRB- C19orf66 -RRB- as an Interferon-Stimulated Cellular Inhibitor against Dengue_Virus Replication .
22882460	0	C1INH	44,49	C1_inhibitor	30,42	C1INH	C1 inhibitor	710	710	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel mutation in exon 8 of C1_inhibitor -LRB- C1INH -RRB- gene leads to abolish its physiological stop codon in a large Chinese family with hereditary_angioedema_type_I .
18758157	0	C1INH	27,32	SERPING1	34,42	C1INH	SERPING1	710	710	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutational spectrum of the C1INH -LRB- SERPING1 -RRB- gene in patients with hereditary_angioedema .
8554610	0	C1Q	42,45	A_beta	75,81	C1Q	A beta	712	351	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Multivalent binding of complement protein C1Q to the amyloid beta-peptide -LRB- A_beta -RRB- promotes the nucleation phase of A_beta aggregation .
1270407	0	C1_esterase_inhibitor	12,33	C1r	55,58	C1 esterase inhibitor	C1r	710	715	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	The role of C1_esterase_inhibitor in the activation of C1r , a subcomponent of the first component of complement from human plasma .
22882460	0	C1_inhibitor	30,42	C1INH	44,49	C1 inhibitor	C1INH	710	710	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel mutation in exon 8 of C1_inhibitor -LRB- C1INH -RRB- gene leads to abolish its physiological stop codon in a large Chinese family with hereditary_angioedema_type_I .
18179772	0	C1q	18,21	Adiponectin	0,11	C1q	Adiponectin	712	9370	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Adiponectin binds C1q and activates the classical pathway of complement .
2005402	0	C1q	88,91	C-reactive_protein	37,55	C1q	C-reactive protein	712	1401	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Binding and complement activation by C-reactive_protein via the collagen-like region of C1q and inhibition of these reactions by monoclonal antibodies to C-reactive_protein and C1q .
10878362	0	C1q	15,18	C1r	56,59	C1q	C1r	712	715	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C1q and mannan-binding_lectin -LRB- MBL -RRB- with C1r , C1s , MBL-associated_serine_proteases_1_and_2 , and the MBL-associated protein MAp19 .
2005109	0	C1q	76,79	C1r	81,84	C1q	C1r	712	715	Gene	Gene	C1s|compound|START_ENTITY C1s|dep|END_ENTITY	Measurement of macromolecular interactions between complement subcomponents C1q , C1r , C1s , and immunoglobulin IgM by sedimentation analysis using the analytical ultracentrifuge .
2372546	0	C1q	99,102	C1r	89,92	C1q	C1r	712	715	Gene	Gene	domain|nmod|START_ENTITY domain|dep|mediates mediates|dep|interaction interaction|nmod|END_ENTITY	NH2-terminal calcium-binding domain of human complement C1s - mediates the interaction of C1r - with C1q .
8042996	0	C1q	183,186	C1r	49,52	C1q	C1r	712	715	Gene	Gene	transmitted|nmod|START_ENTITY signal|acl|transmitted released|nmod|signal control|acl:relcl|released Ca|dep|control down-regulated|nmod|Ca down-regulated|nsubj|Activation Activation|nmod|END_ENTITY	Activation of human complement serine-proteinase C1r is down-regulated by a Ca -LRB- 2 + -RRB- - dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q .
26769276	0	C1q	42,45	C1s	22,25	C1q	C1s	712	716	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity .
10528211	0	C1q	0,3	CR1	35,38	C1q	CR1	712	1378	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	C1q and C4b bind simultaneously to CR1 and additively support erythrocyte adhesion .
8062452	0	C1q	65,68	Calreticulin	0,12	C1q	Calreticulin	712	811	Gene	Gene	neutrophils|nmod|START_ENTITY released|nmod|neutrophils released|nsubjpass|END_ENTITY	Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein .
9324355	0	C1q	57,60	Complement_receptor_type_1	0,26	C1q	Complement receptor type 1	712	1378	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- is a receptor for C1q .
19171874	0	C1q	0,3	IFN-gamma	13,22	C1q	IFN-gamma	712	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells .
10878362	0	C1q	15,18	MBL	46,49	C1q	MBL	712	4153	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of C1q and mannan-binding_lectin -LRB- MBL -RRB- with C1r , C1s , MBL-associated_serine_proteases_1_and_2 , and the MBL-associated protein MAp19 .
26720603	0	C1q	55,58	Paramyosin	21,31	C1q	Paramyosin	712	10913117	Gene	Gene	Binds|dobj|START_ENTITY Binds|nsubj|END_ENTITY	Trichinella_spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation .
22386596	0	C1q	11,14	RAGE	0,4	C1q	RAGE	712	177	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	RAGE binds C1q and enhances C1q-mediated phagocytosis .
6375255	0	C1q	15,18	beta_2-microglobulin	24,44	C1q	beta 2-microglobulin	712	567	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C1q with beta_2-microglobulin .
10413209	0	C1q	0,3	calreticulin	37,49	C1q	calreticulin	712	811	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|binding binding|nmod|END_ENTITY	C1q inhibits autoantibody binding to calreticulin .
11560994	0	C1q	0,3	calreticulin	58,70	C1q	calreticulin	712	811	Gene	Gene	engagement|compound|START_ENTITY surface|nsubj|engagement surface|dobj|initiates initiates|compound|END_ENTITY	C1q and mannose_binding_lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells .
15140059	0	C1q	86,89	calreticulin	37,49	C1q	calreticulin	712	811	Gene	Gene	change|nmod|START_ENTITY requires|dobj|change requires|nsubj|Interaction Interaction|nmod|C1q C1q|nmod|END_ENTITY	Interaction of C1q with the receptor calreticulin requires a conformational change in C1q .
25454607	0	C1q	45,48	calreticulin	26,38	C1q	calreticulin	712	811	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Amblyomma americanum tick calreticulin binds C1q but does not inhibit activation of the classical complement cascade .
9476117	0	C1q	4,7	calreticulin	69,81	C1q	calreticulin	712	811	Gene	Gene	START_ENTITY|nmod|C1q_receptor C1q_receptor|appos|END_ENTITY	The C1q and collectin binding site within C1q_receptor -LRB- cell surface calreticulin -RRB- .
9777407	0	C1q	15,18	calreticulin	67,79	C1q	calreticulin	712	811	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|and_megalin and_megalin|compound|END_ENTITY	Interaction of C1q and the collectins with the potential receptors calreticulin -LRB- cC1qR/collectin _ receptor -RRB- _ and_megalin .
9922153	0	C1q	14,17	calreticulin	104,116	C1q	calreticulin	712	811	Gene	Gene	binds|nsubj|START_ENTITY Evidence|dep|binds present|nsubj|Evidence present|nmod|END_ENTITY	Evidence that C1q binds specifically to CH2-like immunoglobulin gamma motifs present in the autoantigen calreticulin and interferes with complement activation .
19896716	0	C1q	36,39	coat_protein	17,29	C1q	coat protein	712	64083	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Human_astrovirus coat_protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation .
1431141	0	C1q	31,34	decorin	17,24	C1q	decorin	712	1634	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex .
16046396	0	C1q	122,125	fibromodulin	43,55	C1q	fibromodulin	712	2331	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	The extracellular matrix and inflammation : fibromodulin activates the classical pathway of complement by directly binding C1q .
11434933	0	C1q	23,26	interferon-gamma	110,126	C1q	interferon-gamma	712	3458	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of membrane C1q in human monocyte-derived macrophages is developmentally regulated and enhanced by interferon-gamma .
2157659	0	C1q	69,72	myeloperoxidase	50,65	C1q	myeloperoxidase	712	4353	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Protective and inactivating effects of neutrophil myeloperoxidase on C1q activity .
16673132	0	C1qRP	0,5	CD93	7,11	C1qRP	CD93	22918	22918	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	C1qRP -LRB- CD93 -RRB- expression on peripheral blood monocytes in patients with systemic_lupus_erythematosus .
18094537	0	C1qRp	18,23	CD93	12,16	C1qRp	CD93	22918	22918	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Decrease in CD93 -LRB- C1qRp -RRB- expression in a human monocyte-like cell line -LRB- U937 -RRB- treated with various apoptosis-inducing chemical substances .
22740135	0	C1qTNF-related_protein_5	51,75	Ets-2	0,5	C1qTNF-related protein 5	Ets-2	235312(Tax:10090)	23872(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	Ets-2 is involved in transcriptional regulation of C1qTNF-related_protein_5 in muscle cells .
20621834	0	C1qTNF-related_protein_5	74,98	hepatocyte_nuclear_factor-4alpha	8,40	C1qTNF-related protein 5	hepatocyte nuclear factor-4alpha	114902	3172	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of hepatocyte_nuclear_factor-4alpha in transcriptional regulation of C1qTNF-related_protein_5 in the liver .
21453774	0	C1q_and_tumor_necrosis_factor_related_protein_2	80,127	hCTRP2	129,135	C1q and tumor necrosis factor related protein 2	hCTRP2	114898	114898	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High level expression , purification and characterization of active fusion human C1q_and_tumor_necrosis_factor_related_protein_2 -LRB- hCTRP2 -RRB- in Escherichia_coli .
23052251	0	C1q_receptor	34,46	gC1qR	48,53	C1q receptor	gC1qR	22918	708	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of the globular heads of C1q_receptor -LRB- gC1qR -RRB- gene in regulating apoptosis of human cervical_squamous_cell_carcinoma .
1270407	0	C1r	55,58	C1_esterase_inhibitor	12,33	C1r	C1 esterase inhibitor	715	710	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	The role of C1_esterase_inhibitor in the activation of C1r , a subcomponent of the first component of complement from human plasma .
10878362	0	C1r	56,59	C1q	15,18	C1r	C1q	715	712	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C1q and mannan-binding_lectin -LRB- MBL -RRB- with C1r , C1s , MBL-associated_serine_proteases_1_and_2 , and the MBL-associated protein MAp19 .
2005109	0	C1r	81,84	C1q	76,79	C1r	C1q	715	712	Gene	Gene	C1s|dep|START_ENTITY C1s|compound|END_ENTITY	Measurement of macromolecular interactions between complement subcomponents C1q , C1r , C1s , and immunoglobulin IgM by sedimentation analysis using the analytical ultracentrifuge .
2372546	0	C1r	89,92	C1q	99,102	C1r	C1q	715	712	Gene	Gene	interaction|nmod|START_ENTITY mediates|dep|interaction domain|dep|mediates domain|nmod|END_ENTITY	NH2-terminal calcium-binding domain of human complement C1s - mediates the interaction of C1r - with C1q .
8042996	0	C1r	49,52	C1q	183,186	C1r	C1q	715	712	Gene	Gene	Activation|nmod|START_ENTITY down-regulated|nsubj|Activation down-regulated|nmod|Ca Ca|dep|control control|acl:relcl|released released|nmod|signal signal|acl|transmitted transmitted|nmod|END_ENTITY	Activation of human complement serine-proteinase C1r is down-regulated by a Ca -LRB- 2 + -RRB- - dependent intramolecular control that is released in the C1 complex through a signal transmitted by C1q .
10925288	0	C1r	52,55	C1s	20,23	C1r	C1s	715	716	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex .
2372546	0	C1r	89,92	C1s	56,59	C1r	C1s	715	716	Gene	Gene	interaction|nmod|START_ENTITY mediates|dep|interaction domain|dep|mediates domain|nmod|END_ENTITY	NH2-terminal calcium-binding domain of human complement C1s - mediates the interaction of C1r - with C1q .
9477945	0	C1r	97,100	EGF	128,131	C1r	EGF	715	1950	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Solution structure of the epidermal_growth_factor -LRB- EGF -RRB- - like module of human complement protease C1r , an atypical member of the EGF family .
10878362	0	C1r	56,59	MBL	46,49	C1r	MBL	715	4153	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of C1q and mannan-binding_lectin -LRB- MBL -RRB- with C1r , C1s , MBL-associated_serine_proteases_1_and_2 , and the MBL-associated protein MAp19 .
26769276	0	C1s	22,25	C1q	42,45	C1s	C1q	716	712	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity .
10925288	0	C1s	20,23	C1r	52,55	C1s	C1r	716	715	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	The cleavage of two C1s subunits by a single active C1r reveals substantial flexibility of the C1s-C1r-C1r-C1s tetramer in the C1 complex .
2372546	0	C1s	56,59	C1r	89,92	C1s	C1r	716	715	Gene	Gene	domain|nmod|START_ENTITY domain|dep|mediates mediates|dep|interaction interaction|nmod|END_ENTITY	NH2-terminal calcium-binding domain of human complement C1s - mediates the interaction of C1r - with C1q .
16098595	0	C1s	77,80	C4A3	31,35	C1s	C4A3	716	720	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s .
9747507	0	C1s	42,45	bFGF	14,18	C1s	bFGF	716	2247	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of bFGF activity by complement C1s : covalent binding of C1s with bFGF .
9747507	0	C1s	42,45	bFGF	76,80	C1s	bFGF	716	2247	Gene	Gene	activity|nmod|START_ENTITY Inhibition|nmod|activity Inhibition|dep|covalent covalent|nmod|C1s C1s|nmod|END_ENTITY	Inhibition of bFGF activity by complement C1s : covalent binding of C1s with bFGF .
9747507	0	C1s	67,70	bFGF	14,18	C1s	bFGF	716	2247	Gene	Gene	covalent|nmod|START_ENTITY Inhibition|dep|covalent Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of bFGF activity by complement C1s : covalent binding of C1s with bFGF .
8620867	0	C23	0,3	B23	19,22	C23	C23	4691	4691	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	C23 interacts with B23 , a putative nucleolar-localization-signal-binding protein .
26254615	0	C23	31,34	EGFR	52,56	C23	EGFR	4691	1956	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Involvement of nuclear protein C23 in activation of EGFR signaling in cervical_cancer .
11805296	0	C2B	82,85	synaptotagmin_I	96,111	C2B	synaptotagmin I	100130342	6857	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	C2A activates a cryptic Ca -LRB- 2 + -RRB- - triggered membrane penetration activity within the C2B domain of synaptotagmin_I .
15056279	0	C2B	47,50	synaptotagmin_I	69,84	C2B	synaptotagmin I	100130342	6857	Gene	Gene	Identification|nmod|START_ENTITY splice|nsubj|Identification splice|dobj|variant variant|nmod|END_ENTITY	Identification and characterization of a novel C2B splice variant of synaptotagmin_I .
15456828	0	C2B	18,21	synaptotagmin_I	32,47	C2B	synaptotagmin I	233090(Tax:10090)	20979(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Dual roles of the C2B domain of synaptotagmin_I in synchronizing Ca2 + - dependent neurotransmitter release .
22475172	0	C2B	63,66	synaptotagmin_I	83,98	C2B	synaptotagmin I	100130342	6857	Gene	Gene	domain|compound|START_ENTITY interaction|nmod|domain interaction|nmod|END_ENTITY	Molecular level interaction of inositol_hexaphosphate with the C2B domain of human synaptotagmin_I .
9144250	0	C2B	66,69	synaptotagmin_I	80,95	C2B	synaptotagmin I	100130342	6857	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Interaction of the synprint site of N-type Ca2 + channels with the C2B domain of synaptotagmin_I .
9132053	0	C2H2	89,93	zinc_finger_protein	94,113	C2H2	zinc finger protein	830313(Tax:3702)	821212(Tax:3702)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc_finger_protein genes and cDNAs .
23299310	0	C3	36,38	complement_component_3	12,34	C3	complement component 3	12266(Tax:10090)	12266(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of complement_component_3 -LRB- C3 -RRB- in differentiation of myeloid-derived suppressor cells .
19795872	0	C33	13,16	C35	19,22	C33	C35	3732	84299	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Syntheses of C33 - , C35 - , and C39-peridinin and their spectral characteristics .
22504573	0	C3435	36,41	MDR1	31,35	C3435	MDR1	1039312(Tax:199310)	5243	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Meta-analysis of the effect of MDR1 C3435 polymorphism on tacrolimus pharmacokinetics in renal transplant recipients .
19795872	0	C35	19,22	C33	13,16	C35	C33	84299	3732	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Syntheses of C33 - , C35 - , and C39-peridinin and their spectral characteristics .
21190613	0	C3_and_factor_B	75,90	IFN-y	61,66	C3 and factor B	IFN-y	718	3458	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	-LSB- Experimental study of effects of retinoic_acid on IL-1b and IFN-y induced C3_and_factor_B secretion in lung_cancer cell line -RSB- .
7852844	0	C3_and_factor_B_biosynthesis_and_complement_receptor_3	42,96	Transforming_growth_factor_beta	0,31	C3 and factor B biosynthesis and complement receptor 3	Transforming growth factor beta	718	7040	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Transforming_growth_factor_beta modulates C3_and_factor_B_biosynthesis_and_complement_receptor_3 expression in cultured human monocytes .
20942007	0	C3a	16,19	C5a	26,29	C3a	C5a	718	728	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Anaphylatoxins C3a , C4a , C5a -RSB- .
22340339	0	C3a	24,27	C5a	29,32	C3a	C5a	718	728	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of anaphylatoxin C3a , C5a on the tubular_epithelial-myofibroblast_transdifferentiation in vitro .
8955209	0	C3a	31,34	CD88	54,58	C3a	CD88	718	728	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of the C3a and C5a_receptors -LRB- CD88 -RRB- by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines .
20817881	0	C3a	11,14	IFN-a	58,63	C3a	IFN-a	718	111654(Tax:10090)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|production production|amod|END_ENTITY	Complement C3a , CpG oligos , and DNA/C3a complex stimulate IFN-a production in a receptor for advanced glycation end product-dependent manner .
8955209	0	C3a	31,34	IFN-gamma	63,72	C3a	IFN-gamma	718	3458	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of the C3a and C5a_receptors -LRB- CD88 -RRB- by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines .
21598302	0	C3a	11,14	IL-1b	112,117	C3a	IL-1b	718	3553	Gene	Gene	modulate|nsubj|START_ENTITY modulate|nmod|END_ENTITY	Complement C3a and C5a modulate osteoclast formation and inflammatory_response_of_osteoblasts in synergism with IL-1b .
12511407	0	C3a	106,109	SDF-1	153,158	C3a	SDF-1	718	6387	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells , and C3a enhances their homing-related responses to SDF-1 .
16148115	0	C3a	11,14	SDF-1	32,37	C3a	SDF-1	718	6387	Gene	Gene	CXCL12|compound|START_ENTITY CXCL12|appos|END_ENTITY	Complement C3a enhances CXCL12 -LRB- SDF-1 -RRB- - mediated chemotaxis of bone marrow hematopoietic cells independently of C3a_receptor .
9607842	0	C3a	5,8	interleukin-6	34,47	C3a	interleukin-6	718	3569	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|synthesis synthesis|amod|END_ENTITY	Both C3a and C3a -LRB- desArg -RRB- regulate interleukin-6 synthesis in human peripheral blood mononuclear cells .
9712784	0	C3a	15,18	interleukin-8	30,43	C3a	interleukin-8	718	3576	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|secretion secretion|amod|END_ENTITY	Involvement of C3a and C5a in interleukin-8 secretion by human polymorphonuclear cells in response to capsular material of Cryptococcus_neoformans .
18635264	0	C3aR	44,48	complement_anaphylatoxin_receptors	8,42	C3aR	complement anaphylatoxin receptors	84007(Tax:10116)	84007(Tax:10116)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of complement_anaphylatoxin_receptors -LRB- C3aR , C5aR -RRB- in the development of the rat cerebellum .
10469246	0	C3b	81,84	CR1	27,30	C3b	CR1	718	1378	Gene	Gene	internalization|nmod|START_ENTITY Co-operation|nmod|internalization Co-operation|nmod|END_ENTITY	Co-operation between human CR1 -LRB- CD35 -RRB- and CR2 -LRB- CD21 -RRB- in internalization of their C3b and iC3b ligands by murine-transfected fibroblasts .
11955431	0	C3b	17,20	CR1	37,40	C3b	CR1	718	1378	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Structure of the C3b binding site of CR1 -LRB- CD35 -RRB- , the immune adherence receptor .
18717995	0	C3b	24,27	CR1	50,53	C3b	CR1	100862689	1378	Gene	Gene	deposition|nmod|START_ENTITY deposition|nmod|END_ENTITY	Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya : implications for the development of severe anemia .
2138950	0	C3b	33,36	CR1	40,43	C3b	CR1	718	1378	Gene	Gene	START_ENTITY|nmod|B B|compound|END_ENTITY	Competition for binding sites on C3b by CR1 , CR2 , MCP , factor B and factor_H .
2141838	0	C3b	183,186	CR1	83,86	C3b	CR1	718	1378	Gene	Gene	cleavage|nmod|START_ENTITY optima|nmod|cleavage have|dobj|optima have|nsubj|receptor receptor|appos|END_ENTITY	Regulation of proteolytic activity of complement factor I by pH : C3b/C4b _ receptor -LRB- CR1 -RRB- and membrane_cofactor_protein -LRB- MCP -RRB- have different pH optima for factor I-mediated cleavage of C3b .
2527811	0	C3b	47,50	CR1	62,65	C3b	CR1	718	1378	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Interaction between C3 and IL-2 ; inhibition of C3b binding to CR1 by IL-2 .
26415566	0	C3b	58,61	CR1	145,148	C3b	CR1	718	1378	Gene	Gene	feedback|amod|START_ENTITY I|nmod|feedback down-regulation|nmod|I cycle|amod|down-regulation studies|nmod|cycle studies|nmod|END_ENTITY	Further studies of the down-regulation by Factor I of the C3b feedback cycle using endotoxin as a soluble activator and red cells as a source of CR1 on sera of different complotype .
2965698	0	C3b	31,34	CR1	82,85	C3b	CR1	718	1378	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|type type|dep|1 1|appos|END_ENTITY	Interaction of human monomeric C3b with its receptor -LRB- complement receptor type 1 , CR1 -RRB- on neutrophils .
2972794	0	C3b	27,30	CR1	88,91	C3b	CR1	718	1378	Gene	Gene	Identification|nmod|START_ENTITY _|nsubj|Identification _|dobj|receptor receptor|appos|END_ENTITY	Identification of distinct C3b and C4b recognition sites in the human C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- by deletion mutagenesis .
4020137	0	C3b	66,69	CR1	61,64	C3b	CR1	718	1378	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|dep|receptors	Disease-associated loss of erythrocyte complement receptors -LRB- CR1 , C3b receptors -RRB- in patients with systemic_lupus_erythematosus and other diseases involving autoantibodies and/or complement activation .
7033372	0	C3b	58,61	CR1	40,43	C3b	CR1	718	1378	Gene	Gene	microspheres|amod|START_ENTITY Assay|nmod|microspheres Assay|appos|END_ENTITY	Assay of membrane complement receptors -LRB- CR1 and CR2 -RRB- with C3b - and C3d-coated fluorescent microspheres .
7175439	0	C3b	65,68	CR1	39,42	C3b	CR1	718	1378	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes .
8144890	0	C3b	11,14	CR1	54,57	C3b	CR1	718	12902(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of C3b and C4b by the CR1-like site in murine CR1 .
17051150	0	C3b	13,16	CRIg	33,37	C3b	CRIg	718	11326	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Structure of C3b in complex with CRIg gives insights into regulation of complement activation .
301546	0	C3b	153,156	beta1H	130,136	C3b	beta1H	718	3075	Gene	Gene	cleavage|nmod|START_ENTITY END_ENTITY|nmod|cleavage	Human complement C3b_inactivator : isolation , characterization , and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution .
25488663	0	C3b	59,62	complement_C3	42,55	C3b	complement C3	718	718	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	A revised mechanism for the activation of complement_C3 to C3b : a molecular explanation of a disease-associated polymorphism .
21317894	0	C3b	58,61	factor_H	46,54	C3b	factor H	718	3075	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for engagement by complement factor_H of C3b on a self surface .
702059	2	C3b-inactivator	60,75	C4b	53,56	C3b-inactivator	C4b	3426	721	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|proteolysis proteolysis|nmod|END_ENTITY	Role in proteolysis of C4b by C3b-inactivator .
2141826	0	C3b_receptor	55,67	CR1	69,72	C3b receptor	CR1	1378	1378	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of chemotactic peptide f-Met-Leu-Phe -LRB- FMLP -RRB- on C3b_receptor -LRB- CR1 -RRB- expression and phagocytosis of microspheres by human neutrophils .
2429332	0	C3b_receptor	34,46	CR1	48,51	C3b receptor	CR1	1378	1378	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	15-HETE `` modulates '' expression of C3b_receptor -LRB- CR1 -RRB- antigen on peripheral blood B-lymphocytes .
2940981	0	C3b_receptor	22,34	CR1	36,39	C3b receptor	CR1	1378	1378	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Relationships between C3b_receptor -LRB- CR1 -RRB- activity of erythrocytes and positive Coombs ' tests .
2954207	0	C3b_receptor	23,35	CR1	37,40	C3b receptor	CR1	1378	1378	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Erythrocyte complement C3b_receptor -LRB- CR1 -RRB- levels and immune complex-induced manifestations in patients with primary Sj __ gren 's _ syndrome .
2955969	0	C3b_receptor	0,12	CR1	14,17	C3b receptor	CR1	1378	1378	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	C3b_receptor -LRB- CR1 -RRB- expression on the polymorphonuclear leukocytes from patients with systemic_lupus_erythematosus .
8595925	0	C3b_receptor	37,49	CR1	94,97	C3b receptor	CR1	1378	1378	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Hind III genomic polymorphism of the C3b_receptor -LRB- CR1 -RRB- in patients with SLE : low erythrocyte CR1 expression is an acquired phenomenon .
11466369	0	C3d	91,94	CR2	63,66	C3d	CR2	100861467	1380	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Kinetic analysis of the interactions of complement_receptor_2 -LRB- CR2 , CD21 -RRB- with its ligands C3d , iC3b , and the EBV glycoprotein gp350/220 .
1323059	0	C3d	47,50	CR2	61,64	C3d	CR2	100861467	1380	Gene	Gene	receptor|amod|START_ENTITY localization|nmod|receptor localization|appos|END_ENTITY	Nuclear localization of the Epstein-Barr_virus / C3d receptor -LRB- CR2 -RRB- in the human Burkitt B lymphoma cell , Raji .
25433434	0	C3d	26,29	CR2	30,33	C3d	CR2	100861467	1380	Gene	Gene	view|nmod|START_ENTITY view|dep|END_ENTITY	A theoretical view of the C3d : CR2 binding controversy .
2557614	0	C3d	39,42	CR2	53,56	C3d	CR2	100861467	1380	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Epstein-Barr_virus / complement fragment C3d receptor -LRB- CR2 -RRB- reacts with p53 , a cellular antioncogene-encoded membrane phosphoprotein : detection by polyclonal anti-idiotypic anti-CR2 antibodies .
27092816	0	C3d	35,38	CR2	39,42	C3d	CR2	100861467	1380	Gene	Gene	START_ENTITY|dep|Association Association|compound|END_ENTITY	Electrostatic Steering Accelerates C3d : CR2 Association .
3009615	0	C3d	49,52	CR2	63,66	C3d	CR2	100861467	1380	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Incorporation of the purified Epstein_Barr_virus / C3d receptor -LRB- CR2 -RRB- into liposomes and demonstration of its dual ligand binding functions .
7589142	0	C3d	19,22	CR2	33,36	C3d	CR2	100861467	1380	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Epstein-Barr_virus / C3d receptor -LRB- CR2 , CD21 -RRB- activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways .
15713467	0	C3d	65,68	complement_receptor_type_2	27,53	C3d	complement receptor type 2	100861467	1380	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Mutational analysis of the complement_receptor_type_2 -LRB- CR2/CD21 -RRB- - C3d interaction reveals a putative charged SCR1 binding site for C3d .
21285368	0	C3d	34,37	factor_H	20,28	C3d	factor H	100861467	3075	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Dual interaction of factor_H with C3d and glycosaminoglycans in host-nonhost discrimination by complement .
17086422	0	C3d	48,51	hCGbeta	109,116	C3d	hCGbeta	100861467	1082	Gene	Gene	START_ENTITY|nmod|responses responses|nmod|END_ENTITY	The distinct effects of three tandem repeats of C3d in the immune responses against tumor-associated antigen hCGbeta by DNA immunization .
2971638	0	C3d_receptor	19,31	CR2	14,17	C3d receptor	CR2	1380	1380	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CR2 -LRB- C3d_receptor -RRB- on the cell membranes of adult_T_cell_leukemia .
1329034	0	C4	75,77	H-2k	70,74	C4	H-2k	12268(Tax:10090)	14972(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Insertion of the B2 sequence into intron 13 is the only defect of the H-2k C4 gene which causes low C4 production .
458376	0	C4-binding_protein	12,30	C4b	61,64	C4-binding protein	C4b	722	721	Gene	Gene	role|nmod|START_ENTITY role|nmod|proteolysis proteolysis|nmod|END_ENTITY	The role of C4-binding_protein and beta_1H in proteolysis of C4b and C3b .
6601177	0	C4-binding_protein	15,33	C4b	50,53	C4-binding protein	C4b	722	721	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C4-binding_protein with cell-bound C4b .
6601177	1	C4-binding_protein	106,124	C4b	154,157	C4-binding protein	C4b	722	721	Gene	Gene	START_ENTITY|nmod|proteolysis proteolysis|nmod|END_ENTITY	A quantitative analysis of binding and the role of C4-binding_protein in proteolysis of cell-bound C4b .
16098595	0	C4A3	31,35	C1s	77,80	C4A3	C1s	720	716	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s .
14734749	0	C4A_and_C4B	4,15	C4b	60,63	C4A and C4B	C4b	720;721	721	Gene	Gene	forms|amod|START_ENTITY forms|nmod|END_ENTITY	The C4A_and_C4B isotypic forms of human complement fragment C4b have the same intrinsic affinity for complement receptor 1 -LRB- CR1/CD35 -RRB- .
702059	2	C4b	53,56	C3b-inactivator	60,75	C4b	C3b-inactivator	721	3426	Gene	Gene	proteolysis|nmod|START_ENTITY Role|nmod|proteolysis Role|nmod|END_ENTITY	Role in proteolysis of C4b by C3b-inactivator .
458376	0	C4b	61,64	C4-binding_protein	12,30	C4b	C4-binding protein	721	722	Gene	Gene	proteolysis|nmod|START_ENTITY role|nmod|proteolysis role|nmod|END_ENTITY	The role of C4-binding_protein and beta_1H in proteolysis of C4b and C3b .
6601177	0	C4b	50,53	C4-binding_protein	15,33	C4b	C4-binding protein	721	722	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C4-binding_protein with cell-bound C4b .
6601177	1	C4b	154,157	C4-binding_protein	106,124	C4b	C4-binding protein	721	722	Gene	Gene	proteolysis|nmod|START_ENTITY END_ENTITY|nmod|proteolysis	A quantitative analysis of binding and the role of C4-binding_protein in proteolysis of cell-bound C4b .
14734749	0	C4b	60,63	C4A_and_C4B	4,15	C4b	C4A and C4B	721	720;721	Gene	Gene	forms|nmod|START_ENTITY forms|amod|END_ENTITY	The C4A_and_C4B isotypic forms of human complement fragment C4b have the same intrinsic affinity for complement receptor 1 -LRB- CR1/CD35 -RRB- .
12667215	0	C4b	90,93	CR1	2,5	C4b	CR1	721	1378	Gene	Gene	binding|nmod|START_ENTITY affects|xcomp|binding affects|nsubj|polymorphism polymorphism|compound|END_ENTITY	A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b .
12667215	0	C4b	90,93	CR1	60,63	C4b	CR1	721	1378	Gene	Gene	binding|nmod|START_ENTITY affects|xcomp|binding affects|nsubj|polymorphism polymorphism|acl|associated associated|nmod|levels levels|compound|END_ENTITY	A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b .
1386357	0	C4b	52,55	CR1	102,105	C4b	CR1	721	1378	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|pathway pathway|nmod|receptor receptor|appos|END_ENTITY	Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- and membrane_cofactor_protein -LRB- MCP , CD46 -RRB- .
2430040	0	C4b	15,18	CR1	67,70	C4b	CR1	721	1378	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Membrane-bound C4b interacts endogenously with complement receptor CR1 of human red cells .
8757632	0	C4b	59,62	CR1	79,82	C4b	CR1	462577(Tax:9598)	449643(Tax:9598)	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Substitution of two amino_acids confers C3b binding to the C4b binding site of CR1 -LRB- CD35 -RRB- .
1386357	0	C4b	52,55	MCP	144,147	C4b	MCP	721	4179	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|pathway pathway|nmod|receptor receptor|appos|END_ENTITY	Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- and membrane_cofactor_protein -LRB- MCP , CD46 -RRB- .
12055245	0	C4b	58,61	membrane_cofactor_protein	8,33	C4b	membrane cofactor protein	721	4179	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of membrane_cofactor_protein -LRB- CD46 -RRB- in regulation of C4b and C3b deposited on cells .
8928088	0	C4b-binding_protein	57,76	IL-1_alpha	21,31	C4b-binding protein	IL-1 alpha	722	3552	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	TNF-alpha suppresses IL-1_alpha and IL-6 upregulation of C4b-binding_protein in HepG-2 hepatoma cells .
27050367	0	C4b-binding_protein_a	41,62	Sp1	103,106	C4b-binding protein a	Sp1	722	6667	Gene	Gene	START_ENTITY|advcl|activating activating|dobj|END_ENTITY	Hepatitis_B_virus X protein up-regulates C4b-binding_protein_a through activating transcription factor Sp1 in protection of hepatoma cells from complement attack .
22084725	0	C5	43,45	Component_5	30,41	C5	Component 5	727	727	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	High Expression of Complement Component_5 -LRB- C5 -RRB- at Tumor Site Associates with Superior Survival in Ewing 's _ Sarcoma Family of Tumour Patients .
11773063	0	C5L2	20,24	C5a	82,85	C5L2	C5a	445269(Tax:10116)	362119(Tax:10116)	Gene	Gene	has|nsubj|START_ENTITY has|dobj|sites sites|nmod|END_ENTITY	The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg -LRB- 74 -RRB- .
17322907	0	C5L2	0,4	C5a	69,72	C5L2	C5a	319430(Tax:10090)	15139(Tax:10090)	Gene	Gene	critical|nsubj|START_ENTITY critical|nmod|activities activities|nmod|END_ENTITY	C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a .
21630250	0	C5L2	113,117	C5a	99,102	C5L2	C5a	319430(Tax:10090)	15139(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor , C5L2 .
23239822	0	C5L2	0,4	C5a	60,63	C5L2	C5a	27202	728	Gene	Gene	START_ENTITY|dep|receptor receptor|nmod|anaphylatoxin anaphylatoxin|appos|END_ENTITY	C5L2 : a controversial receptor of complement anaphylatoxin , C5a .
20942007	0	C5a	26,29	C3a	16,19	C5a	C3a	728	718	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Anaphylatoxins C3a , C4a , C5a -RSB- .
22340339	0	C5a	29,32	C3a	24,27	C5a	C3a	728	718	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of anaphylatoxin C3a , C5a on the tubular_epithelial-myofibroblast_transdifferentiation in vitro .
11773063	0	C5a	82,85	C5L2	20,24	C5a	C5L2	362119(Tax:10116)	445269(Tax:10116)	Gene	Gene	sites|nmod|START_ENTITY has|dobj|sites has|nsubj|END_ENTITY	The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg -LRB- 74 -RRB- .
17322907	0	C5a	69,72	C5L2	0,4	C5a	C5L2	15139(Tax:10090)	319430(Tax:10090)	Gene	Gene	activities|nmod|START_ENTITY critical|nmod|activities critical|nsubj|END_ENTITY	C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a .
21630250	0	C5a	99,102	C5L2	113,117	C5a	C5L2	15139(Tax:10090)	319430(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor , C5L2 .
23239822	0	C5a	60,63	C5L2	0,4	C5a	C5L2	728	27202	Gene	Gene	anaphylatoxin|appos|START_ENTITY receptor|nmod|anaphylatoxin END_ENTITY|dep|receptor	C5L2 : a controversial receptor of complement anaphylatoxin , C5a .
3318320	0	C5a	11,14	C5a	65,68	C5a	C5a	728	728	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	High-level C5a gene expression and recovery of recombinant human C5a from Escherichia_coli .
3318320	0	C5a	65,68	C5a	11,14	C5a	C5a	728	728	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	High-level C5a gene expression and recovery of recombinant human C5a from Escherichia_coli .
6809882	0	C5a	119,122	C5a	93,96	C5a	C5a	728	728	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Induction of interleukin_1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors .
6809882	0	C5a	93,96	C5a	119,122	C5a	C5a	728	728	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Induction of interleukin_1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors .
8182049	0	C5a	118,121	C5a	75,78	C5a	C5a	728	728	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	The amino terminus of the human C5a_receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs .
8182049	0	C5a	75,78	C5a	118,121	C5a	C5a	728	728	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	The amino terminus of the human C5a_receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs .
11342590	0	C5a	54,57	C5a_anaphylatoxin_receptor	84,110	C5a	C5a anaphylatoxin receptor	728	728	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a_anaphylatoxin_receptor .
23394121	0	C5a	31,34	CD88	46,50	C5a	CD88	728	728	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Complement activation fragment C5a receptors , CD88 and C5L2 , are associated with neurofibrillary pathology .
15313431	0	C5a	0,3	ERK1/2	34,40	C5a	ERK1/2	728	5595;5594	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	C5a differentially stimulates the ERK1/2 and p38_MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264 .7 macrophages .
19200233	0	C5a	37,40	GLT-1	62,67	C5a	GLT-1	728	6506	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner .
11160333	0	C5a	131,134	Gc-globulin	64,75	C5a	Gc-globulin	728	2638	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity role|nmod|regulation the|dep|role the|nmod|protein protein|appos|END_ENTITY	Elastase controls the binding of the vitamin_D-binding protein -LRB- Gc-globulin -RRB- to neutrophils : a potential role in the regulation of C5a co-chemotactic activity .
15356163	0	C5a	137,140	Gc-globulin	82,93	C5a	Gc-globulin	728	2638	Gene	Gene	cofactor|nmod|START_ENTITY function|nmod|cofactor necessary|xcomp|function necessary|nmod|protein protein|appos|END_ENTITY	Platelet-derived thrombospondin-1 is necessary for the vitamin_D-binding protein -LRB- Gc-globulin -RRB- to function as a chemotactic cofactor for C5a .
18538666	0	C5a	5,8	Gc-globulin	110,121	C5a	Gc-globulin	728	2638	Gene	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|mortality mortality|dep|effect effect|nmod|END_ENTITY	High C5a levels are associated with increased mortality in sepsis patients -- no enhancing effect by actin-free Gc-globulin .
3392213	0	C5a	88,91	Gc-globulin	0,11	C5a	Gc-globulin	728	2638	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Gc-globulin -LRB- vitamin_D-binding protein -RRB- enhances the neutrophil chemotactic activity of C5a and C5a des Arg .
7594552	0	C5a	69,72	Gc-globulin	25,36	C5a	Gc-globulin	728	2638	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Co-chemotactic effect of Gc-globulin -LRB- vitamin_D binding protein -RRB- for C5a .
7616106	0	C5a	54,57	Gc_globulin	11,22	C5a	Gc globulin	728	2638	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Gc_globulin -LRB- vitamin_D binding protein -RRB- to C5a or C5a des Arg is not necessary for co-chemotactic activity .
20484595	0	C5a	21,24	ICAM-1	35,41	C5a	ICAM-1	728	3383	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells .
21106540	0	C5a	0,3	IL-10	25,30	C5a	IL-10	15139(Tax:10090)	16153(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase .
20140904	0	C5a	11,14	IL-17	25,30	C5a	IL-17	15139(Tax:10090)	16171(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis .
21762495	0	C5a	21,24	IL-22	48,53	C5a	IL-22	728	50616	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular_degeneration .
10799912	0	C5a	38,41	IL-6	101,105	C5a	IL-6	362119(Tax:10116)	24498(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY receptors|nsubj|Induction receptors|nmod|treatment treatment|nmod|rats rats|nmod|END_ENTITY	Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6 .
11564816	0	C5a	14,17	IL-6	161,165	C5a	IL-6	362119(Tax:10116)	24498(Tax:10116)	Gene	Gene	actions|amod|START_ENTITY actions|dep|expression expression|nmod|hepatocytes hepatocytes|nmod|release release|compound|END_ENTITY	Anaphylatoxin C5a actions in rat liver : synergistic enhancement by C5a of lipopolysaccharide-dependent alpha -LRB- 2 -RRB- - macroglobulin gene expression in hepatocytes via IL-6 release from Kupffer cells .
11564816	0	C5a	67,70	IL-6	161,165	C5a	IL-6	362119(Tax:10116)	24498(Tax:10116)	Gene	Gene	enhancement|nmod|START_ENTITY actions|dep|enhancement actions|dep|expression expression|nmod|hepatocytes hepatocytes|nmod|release release|compound|END_ENTITY	Anaphylatoxin C5a actions in rat liver : synergistic enhancement by C5a of lipopolysaccharide-dependent alpha -LRB- 2 -RRB- - macroglobulin gene expression in hepatocytes via IL-6 release from Kupffer cells .
12496437	0	C5a	68,71	IL-6	22,26	C5a	IL-6	15139(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY linked|nmod|expression linked|nsubjpass|effects effects|nmod|blockade blockade|compound|END_ENTITY	Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression .
14688199	0	C5a	19,22	IL-6	38,42	C5a	IL-6	362119(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis .
1602137	0	C5a	72,75	IL-6	107,111	C5a	IL-6	728	3569	Gene	Gene	region|nmod|START_ENTITY Identification|nmod|region Identification|amod|responsible responsible|nmod|stimulation stimulation|nmod|synthesis synthesis|compound|END_ENTITY	Identification and characterization of the effector region within human C5a responsible for stimulation of IL-6 synthesis .
19172471	0	C5a	0,3	VEGF	28,32	C5a	VEGF	728	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	C5a , but not C3a , increases VEGF secretion in ARPE-19 human retinal pigment epithelial cells .
10929868	0	C5a	0,3	interleukin-6	45,58	C5a	interleukin-6	728	3569	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|production production|amod|END_ENTITY	C5a modulation of interleukin-1_beta-induced interleukin-6 production by human osteoblast-like cells .
11875003	0	C5a	27,30	interleukin-6	104,117	C5a	interleukin-6	362119(Tax:10116)	24498(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY Induction|nmod|receptors Induction|dep|mediation mediation|nmod|cells cells|amod|END_ENTITY	Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo : mediation by interleukin-6 from Kupffer cells .
1499642	0	C5a	18,21	interleukin-6	71,84	C5a	interleukin-6	728	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|synthesis synthesis|nmod|END_ENTITY	Human recombinant C5a enhances lipopolysaccharide-induced synthesis of interleukin-6 by human monocytes .
1769685	0	C5a	12,15	interleukin-6	19,32	C5a	interleukin-6	728	3569	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The role of C5a in interleukin-6 production induced by lipopolysaccharide or interleukin-1 .
11321363	0	C5a	11,14	interleukin-8	27,40	C5a	interleukin-8	728	3576	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of C5a and FMLP on interleukin-8 production and proliferation of human umbilical vein endothelial cells .
1690130	0	C5a	12,15	interleukin_1	25,38	C5a	interleukin 1	728	3552	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|release release|amod|END_ENTITY	Recombinant C5a enhances interleukin_1 and tumor_necrosis_factor release by lipopolysaccharide-stimulated monocytes and macrophages .
3116090	0	C5a	0,3	interleukin_1	23,36	C5a	interleukin 1	728	3552	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	C5a induction of human interleukin_1 .
6809882	0	C5a	119,122	interleukin_1	13,26	C5a	interleukin 1	728	3552	Gene	Gene	binding|nmod|START_ENTITY receptors|amod|binding Induction|nmod|receptors Induction|nmod|secretion secretion|amod|END_ENTITY	Induction of interleukin_1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors .
6809882	0	C5a	93,96	interleukin_1	13,26	C5a	interleukin 1	728	3552	Gene	Gene	binding|nmod|START_ENTITY receptors|amod|binding Induction|nmod|receptors Induction|nmod|secretion secretion|amod|END_ENTITY	Induction of interleukin_1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors .
18187666	0	C5a	46,49	oncostatin_M	76,88	C5a	oncostatin M	728	5008	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	In human macrophages the complement component C5a induces the expression of oncostatin_M via AP-1 activation .
2307846	0	C5a	11,14	phospholipase_D	29,44	C5a	phospholipase D	728	2822	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Complement C5a activation of phospholipase_D in human neutrophils .
16879222	0	C5a	25,28	plasminogen_activator_inhibitor-1	55,88	C5a	plasminogen activator inhibitor-1	728	5054	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The complement component C5a induces the expression of plasminogen_activator_inhibitor-1 in human macrophages via NF-kappaB activation .
19278588	0	C5a	11,14	thrombomodulin	32,46	C5a	thrombomodulin	728	7056	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of C5a on expression of thrombomodulin in endothelial cells in vitro -RSB- .
3260938	0	C5a	0,3	tumor_necrosis_factor	28,49	C5a	tumor necrosis factor	728	7124	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	C5a stimulates secretion of tumor_necrosis_factor from human mononuclear cells in vitro .
7797249	0	C5aR	57,61	C5a_anaphylatoxin_receptor	29,55	C5aR	C5a anaphylatoxin receptor	728	728	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the complement C5a_anaphylatoxin_receptor -LRB- C5aR -RRB- on non-myeloid cells .
8759762	0	C5aR	37,41	CD117	52,57	C5aR	CD117	728	3815	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	CD88 antibodies specifically bind to C5aR on dermal CD117 + and CD14 + cells and react with a desmosomal antigen in human skin .
12070675	0	C5aR	41,45	CD88	47,51	C5aR	CD88	728	728	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the anaphylatoxin receptor C5aR -LRB- CD88 -RRB- by human articular chondrocytes .
25585930	0	C5aR	131,135	GPCR	125,129	C5aR	GPCR	728	441931	Gene	Gene	Signalling|appos|START_ENTITY Signalling|compound|END_ENTITY	A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR -LRB- C5aR -RRB- Signalling .
11342590	0	C5a_anaphylatoxin_receptor	84,110	C5a	54,57	C5a anaphylatoxin receptor	C5a	728	728	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a_anaphylatoxin_receptor .
7797249	0	C5a_anaphylatoxin_receptor	29,55	C5aR	57,61	C5a anaphylatoxin receptor	C5aR	728	728	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the complement C5a_anaphylatoxin_receptor -LRB- C5aR -RRB- on non-myeloid cells .
16997854	0	C5a_anaphylatoxin_receptor	90,116	CD3	127,130	C5a anaphylatoxin receptor	CD3	12273(Tax:10090)	12501(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a_anaphylatoxin_receptor -LRB- CD88 -RRB- in CD3 + murine T cells .
10996218	0	C5a_receptor	25,37	CD88	39,43	C5a receptor	CD88	12273(Tax:10090)	12273(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Intracerebral complement C5a_receptor -LRB- CD88 -RRB- expression is regulated by TNF and lymphotoxin-alpha following closed_head_injury in mice .
12225614	0	C5a_receptor	18,30	CD88	32,36	C5a receptor	CD88	728	728	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the C5a_receptor -LRB- CD88 -RRB- on granulocytes and monocytes in patients with severe sepsis .
22249919	0	C5a_receptor	0,12	CD88	14,18	C5a receptor	CD88	728	728	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	C5a_receptor -LRB- CD88 -RRB- inhibition improves hypothermia-induced neuroprotection in an in vitro ischemic model .
8911150	0	C5a_receptor	29,41	CD88	43,47	C5a receptor	CD88	728	728	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and modulation of C5a_receptor -LRB- CD88 -RRB- on skin dendritic cells .
9286351	0	C5a_receptor	40,52	CD88	54,58	C5a receptor	CD88	728	728	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Functional expression and modulation of C5a_receptor -LRB- CD88 -RRB- on skin dendritic cells .
9485081	0	C5a_receptor	18,30	CD88	32,36	C5a receptor	CD88	728	728	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the C5a_receptor -LRB- CD88 -RRB- on synovial mast cells in patients with rheumatoid_arthritis .
10996218	0	C5a_receptor	25,37	TNF	72,75	C5a receptor	TNF	12273(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Intracerebral complement C5a_receptor -LRB- CD88 -RRB- expression is regulated by TNF and lymphotoxin-alpha following closed_head_injury in mice .
25736925	0	C6orf106	0,8	vimentin	54,62	C6orf106	vimentin	64771	7431	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	C6orf106 enhances NSCLC cell invasion by upregulating vimentin , and downregulating E-cadherin and P120ctn .
20452750	0	C6orf217	78,86	AHI1	36,40	C6orf217	AHI1	100131814	54806	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Lymphoblast and brain expression of AHI1 and the novel primate-specific gene , C6orf217 , in schizophrenia and bipolar_disorder .
12665628	0	C8orf17	24,31	MOST-1	16,22	C8orf17	MOST-1	100507249	100507249	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The novel human MOST-1 -LRB- C8orf17 -RRB- gene exhibits tissue specific expression , maps to chromosome 8q24 .2 , and is overexpressed/amplified in high grade cancers of the breast and prostate .
25869879	0	C8orf4	28,34	TC1	23,26	C8orf4	TC1	56892	56892	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The high expression of TC1 -LRB- C8orf4 -RRB- was correlated with the expression of b-catenin and cyclin_D1 and the progression of squamous_cell_carcinomas of the tongue .
27103069	0	C9ORF72	8,15	Ataxin-2	60,68	C9ORF72	Ataxin-2	203228	6311	Gene	Gene	Loss|nmod|START_ENTITY impairs|nsubj|Loss impairs|nmod|END_ENTITY	Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron_dysfunction and cell death .
24608043	0	C9orf140	8,16	STAT5	120,125	C9orf140	STAT5	89958	6776	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of C9orf140 in the promotion of colorectal_cancer progression and mechanisms of its upregulation via activation of STAT5 , b-catenin and EZH2 .
19008051	0	CA-9	60,64	carbonic_anhydrase-9	38,58	CA-9	carbonic anhydrase-9	768	768	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Assessment of microvessel density and carbonic_anhydrase-9 -LRB- CA-9 -RRB- expression in rectal_cancer .
9878252	0	CA-RP_XI	152,160	CA11	167,171	CA-RP XI	CA11	770	770	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evolutionarily conserved , `` acatalytic '' carbonic_anhydrase-related_protein_XI contains a sequence motif present in the neuropeptide sauvagine : the human CA-RP_XI gene -LRB- CA11 -RRB- is embedded between the secretor gene cluster and the DBP gene at 19q13 .3 .
7472476	0	CA1	58,61	5-HT1A	33,39	CA1	5-HT1A	310218(Tax:10116)	24473(Tax:10116)	Gene	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro .
20981413	0	CA1	34,37	5-HT1A_receptor	69,84	CA1	5-HT1A receptor	12346(Tax:10090)	15550(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|mice mice|amod|END_ENTITY	Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A_receptor knockout mice .
15951119	0	CA1	91,94	A-kinase_anchoring_protein	41,67	CA1	A-kinase anchoring protein	310218(Tax:10116)	171026(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY localization|nmod|cells localization|nmod|END_ENTITY	Synaptic and subcellular localization of A-kinase_anchoring_protein 150 in rat hippocampal CA1 pyramidal cells : Co-localization with excitatory synaptic markers .
9512001	0	CA1	77,80	AP1	46,49	CA1	AP1	759	3725	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Prolongation by bifemelane of potentiation of AP1 DNA binding in hippocampal CA1 subfield of gerbils with transient forebrain_ischemia .
10686068	0	CA1	63,66	CREB	11,15	CA1	CREB	310218(Tax:10116)	81646(Tax:10116)	Gene	Gene	pyramidal_neurons|compound|START_ENTITY protection|nmod|pyramidal_neurons phosphorylation|nmod|protection phosphorylation|nsubj|END_ENTITY	Persistent CREB phosphorylation with protection of hippocampal CA1 pyramidal_neurons following temporary occlusion of the middle cerebral artery in the rat .
12887679	0	CA1	77,80	CREB	0,4	CA1	CREB	12346(Tax:10090)	12912(Tax:10090)	Gene	Gene	region|compound|START_ENTITY tolerance|nmod|region acquisition|nmod|tolerance required|nmod|acquisition required|nsubjpass|END_ENTITY	CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region .
17161830	0	CA1	145,148	CREB	117,121	CA1	CREB	310218(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|element-binding element-binding|appos|END_ENTITY	Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated_cAMP response element-binding -LRB- CREB -RRB- protein expression in CA1 of ovariectomized rat hippocampus .
17303091	0	CA1	54,57	CREB	14,18	CA1	CREB	12346(Tax:10090)	12912(Tax:10090)	Gene	Gene	region|compound|START_ENTITY phosphorylation|nmod|region phosphorylation|compound|END_ENTITY	Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse -LRB- SAM -RRB- P8 .
20848600	0	CA1	72,75	CREB	36,40	CA1	CREB	12346(Tax:10090)	12912(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Extinction of spatial memory alters CREB phosphorylation in hippocampal CA1 .
21734652	0	CA1	32,35	CREB	11,15	CA1	CREB	12346(Tax:10090)	12912(Tax:10090)	Gene	Gene	region|compound|START_ENTITY function|nmod|region function|compound|END_ENTITY	Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory_deficits in a mouse model of Alzheimer 's _ disease .
22817531	0	CA1	21,24	CREB	99,103	CA1	CREB	310218(Tax:10116)	81646(Tax:10116)	Gene	Gene	neurons|nummod|START_ENTITY prevents|dobj|neurons prevents|nmod|modulation modulation|nmod|pathways pathways|amod|GSK-3b GSK-3b|advmod|END_ENTITY	Resveratrol prevents CA1 neurons against ischemic_injury by parallel modulation of both GSK-3b and CREB through PI3-K/Akt pathways .
8864483	0	CA1	80,83	Ca2	43,46	CA1	Ca2	100720116	100719293	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Extracellular Mg2 + modulates intracellular Ca2 + in acutely isolated hippocampal CA1 pyramidal cells of the guinea-pig .
10902897	0	CA1	59,62	Fos	27,30	CA1	Fos	310218(Tax:10116)	314322(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Estradiol induces a phasic Fos response in the hippocampal CA1 and CA3 regions of adult female rats .
15033432	0	CA1	83,86	Fos	42,45	CA1	Fos	310218(Tax:10116)	314322(Tax:10116)	Gene	Gene	decreased|nmod|START_ENTITY decreased|dobj|induction induction|nmod|protein protein|compound|END_ENTITY	Nociception-driven decreased induction of Fos protein in ventral hippocampus field CA1 of the rat .
15554911	0	CA1	123,126	Fos	101,104	CA1	Fos	310218(Tax:10116)	314322(Tax:10116)	Gene	Gene	hippocampus|compound|START_ENTITY associated|nmod|hippocampus associated|nmod|increase increase|nmod|expression expression|compound|END_ENTITY	Improvement of spatial cognition with dietary docosahexaenoic_acid is associated with an increase in Fos expression in rat CA1 hippocampus .
24442982	0	CA1	71,74	GLT-1	41,46	CA1	GLT-1	310218(Tax:10116)	29482(Tax:10116)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Up-regulation of neuronal and astrocytic GLT-1 mRNA in the hippocampal CA1 subfield during the induction of brain ischemic tolerance in rats .
16481459	0	CA1	65,68	Growth_hormone	0,14	CA1	Growth hormone	310218(Tax:10116)	81668(Tax:10116)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Growth_hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus .
19073170	0	CA1	51,54	HCN1	21,25	CA1	HCN1	759	348980	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	WITHDRAWN : Decreased HCN1 mRNA in hippocampal area CA1 and neocortex after chronic cerebral_hypoperfusion .
23907317	0	CA1	28,31	IQGAP1	0,6	CA1	IQGAP1	12346(Tax:10090)	29875(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	IQGAP1 expression in spared CA1 neurons after an excitotoxic lesion in the mouse hippocampus .
17292799	0	CA1	96,99	NMDAR1	109,115	CA1	NMDAR1	12346(Tax:10090)	14810(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Effects of enriched environment on gene expression and signal pathways in cortex of hippocampal CA1 specific NMDAR1 knockout mice .
25276438	0	CA1	50,53	NR2B	58,62	CA1	NR2B	12346(Tax:10090)	14812(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Receptors Receptors|compound|END_ENTITY	Abeta -LRB- 1-42 -RRB- Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors .
10492008	0	CA1	90,93	NT-3	9,13	CA1	NT-3	310218(Tax:10116)	81737(Tax:10116)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Neuronal NT-3 is not required for synaptic transmission or long-term potentiation in area CA1 of the adult rat hippocampus .
2996711	0	CA1	82,85	Neuropeptide_Y	0,14	CA1	Neuropeptide Y	310218(Tax:10116)	24604(Tax:10116)	Gene	Gene	spike|nmod|START_ENTITY reduces|dobj|spike reduces|nsubj|END_ENTITY	Neuropeptide_Y reduces orthodromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism .
10200199	0	CA1	21,24	Somatostatin	0,12	CA1	Somatostatin	310218(Tax:10116)	24797(Tax:10116)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Somatostatin acts in CA1 and CA3 to reduce hippocampal_epileptiform_activity .
22679726	0	CA1	193,196	brain_derived_neurotrophic_factor	105,138	CA1	brain derived neurotrophic factor	310218(Tax:10116)	24225(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of electroacupuncture combined with compound Salviae Miltiorrhizae tablet on the expressions of brain_derived_neurotrophic_factor and vascular_endothelial_growth_factor in hippocampus CA1 of chronic_cerebral_ischemia rats -RSB- .
12865128	0	CA1	102,105	c-Fos	52,57	CA1	c-Fos	759	2353	Gene	Gene	region|compound|START_ENTITY suppresses|nmod|region suppresses|dobj|increase increase|nmod|expression expression|amod|END_ENTITY	Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils .
12882314	0	CA1	89,92	c-Fos	60,65	CA1	c-Fos	12346(Tax:10090)	14281(Tax:10090)	Gene	Gene	hippocampus|nummod|START_ENTITY induces|nmod|hippocampus induces|dobj|expression expression|amod|END_ENTITY	Memory retrieval after contextual fear conditioning induces c-Fos and JunB expression in CA1 hippocampus .
22285885	0	CA1	103,106	c-Fos	107,112	CA1	c-Fos	310218(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Neonatal alcohol exposure and the hippocampus in developing male rats : effects on behaviorally induced CA1 c-Fos expression , CA1 pyramidal cell number , and contextual fear conditioning .
12853419	0	CA1	103,106	c-fos	0,5	CA1	c-fos	310218(Tax:10116)	314322(Tax:10116)	Gene	Gene	region|compound|START_ENTITY expression|nmod|region reduces|nmod|expression reduces|nsubj|END_ENTITY	c-fos reduces corticosterone-mediated effects on neurotrophic_factor expression in the rat hippocampal CA1 region .
7623110	0	CA1	133,136	c-fos	11,16	CA1	c-fos	310218(Tax:10116)	314322(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY Changes|dep|involvement Changes|nmod|expression expression|amod|END_ENTITY	Changes in c-fos mRNA expression in rat brain during odor discrimination learning : differential involvement of hippocampal subfields CA1 and CA3 .
21179765	0	CA1	165,168	fos	127,130	CA1	fos	759	2353	Gene	Gene	area|compound|START_ENTITY expressions|nmod|area expressions|nmod|END_ENTITY	-LSB- The relationship between the effects of curcumin on cerebral_ischemia / reperfusion injury and immediately genic expressions of fos , Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils -RSB- .
1313731	0	CA1	144,147	neuropeptide_Y	78,92	CA1	neuropeptide Y	310218(Tax:10116)	24604(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	4-Aminopyridine and low Ca2 + differentiate presynaptic inhibition mediated by neuropeptide_Y , baclofen and 2-chloroadenosine in rat hippocampal CA1 in vitro .
8616513	0	CA1	54,57	neuropeptide_Y	11,25	CA1	neuropeptide Y	310218(Tax:10116)	24604(Tax:10116)	Gene	Gene	region|compound|START_ENTITY potentials|nmod|region END_ENTITY|nmod|potentials	Effects of neuropeptide_Y on evoked potentials in the CA1 region and the dentate gyrus of the rat hippocampal slice .
12853419	0	CA1	103,106	neurotrophic_factor	49,68	CA1	neurotrophic factor	310218(Tax:10116)	81737(Tax:10116)	Gene	Gene	region|compound|START_ENTITY expression|nmod|region expression|compound|END_ENTITY	c-fos reduces corticosterone-mediated effects on neurotrophic_factor expression in the rat hippocampal CA1 region .
21314692	0	CA1	124,127	sigma-1_receptor	81,97	CA1	sigma-1 receptor	310218(Tax:10116)	29336(Tax:10116)	Gene	Gene	neurons|compound|START_ENTITY activation|nmod|neurons activation|amod|END_ENTITY	Ethanol exposure in early adolescence inhibits intrinsic neuronal plasticity via sigma-1_receptor activation in hippocampal CA1 neurons .
9878252	0	CA11	167,171	CA-RP_XI	152,160	CA11	CA-RP XI	770	770	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evolutionarily conserved , `` acatalytic '' carbonic_anhydrase-related_protein_XI contains a sequence motif present in the neuropeptide sauvagine : the human CA-RP_XI gene -LRB- CA11 -RRB- is embedded between the secretor gene cluster and the DBP gene at 19q13 .3 .
2426374	0	CA125	19,24	AFP	31,34	CA125	AFP	94025	174	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Analysis of serum CA125 , CEA , AFP , LDH levels and LDH isoenzymes in patients with ovarian_tumors -- correlation between tumor markers and histological types of ovarian_tumors -RSB- .
3467786	0	CA125	22,27	CA19-9_and_CEA	68,82	CA125	CA19-9 and CEA	94025	1084	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Tumour marker antigen CA125 in pancreatic_cancer : a comparison with CA19-9_and_CEA .
10770115	0	CA125	5,10	CEA	0,3	CA125	CEA	94025	1084	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	CEA , CA125 and CA19-9 levels in congenital_gastrointestinal_anomalies .
18609108	0	CA125	56,61	CEA	50,53	CA125	CEA	94025	1084	Gene	Gene	intervals|appos|START_ENTITY intervals|nmod|carcinoembryonic_antigen carcinoembryonic_antigen|appos|END_ENTITY	Reference intervals for carcinoembryonic_antigen -LRB- CEA -RRB- , CA125 , MUC1 , Alfa-foeto-protein -LRB- AFP -RRB- , neuron-specific_enolase -LRB- NSE -RRB- and CA19 .9 from the NORIP study .
19383238	0	CA125	74,79	CEA	48,51	CA125	CEA	94025	1084	Gene	Gene	125|appos|START_ENTITY antigen|dep|125 efficacy|appos|antigen efficacy|nmod|carcinoembryonic_antigen carcinoembryonic_antigen|appos|END_ENTITY	The efficacy of serum carcinoembryonic_antigen -LRB- CEA -RRB- , cancer antigen 125 -LRB- CA125 -RRB- , carbohydrate antigen 19-9 -LRB- CA19-9 -RRB- , carbohydrate_antigen_15-3 -LRB- CA15-3 -RRB- , alpha-fetoprotein -LRB- AFP -RRB- and human chorionic_gonadotropin _ -LRB- hCG -RRB- levels in determining the malignancy of solitary_pulmonary_nodules .
3165255	0	CA125	110,115	CEA	181,184	CA125	CEA	94025	1084	Gene	Gene	cultures|appos|START_ENTITY cultures|dobj|_ _|appos|END_ENTITY	Experiments with tissue cultures from a human ovarian_serous_cystadenocarcinoma producing cancer antigen 125 -LRB- CA125 -RRB- , tissue_polypeptide_antigen _ -LRB- TPA -RRB- _ and_carcinoembryonic_antigen _ -LRB- CEA -RRB- .
8690294	0	CA125	18,23	CEA	33,36	CA125	CEA	94025	1084	Gene	Gene	CA72-4|compound|START_ENTITY CA72-4|appos|END_ENTITY	Clinical value of CA125 , CA19-9 , CEA , CA72-4 , and TPA_in_borderline_ovarian_tumor .
22284961	0	CA125	51,56	HE4	6,9	CA125	HE4	94025	10406	Gene	Gene	elevated|dobj|START_ENTITY elevated|nsubj|END_ENTITY	Serum HE4 levels are less frequently elevated than CA125 in women with benign_gynecologic_disorders .
26918940	0	CA125	58,63	MUC16	51,56	CA125	MUC16	94025	94025	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Tumor_necrosis_factor-a and interferon-y stimulate MUC16 -LRB- CA125 -RRB- expression in breast , endometrial_and_ovarian_cancers through NFkB .
26918940	0	CA125	58,63	Tumor_necrosis_factor-a	0,23	CA125	Tumor necrosis factor-a	94025	7124	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-a and interferon-y stimulate MUC16 -LRB- CA125 -RRB- expression in breast , endometrial_and_ovarian_cancers through NFkB .
7981075	0	CA125	60,65	Tumour-associated_trypsin_inhibitor	0,35	CA125	Tumour-associated trypsin inhibitor	94025	6690	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Tumour-associated_trypsin_inhibitor -LRB- TATI -RRB- : comparison with CA125 as a preoperative prognostic indicator in advanced ovarian_cancer .
26143638	0	CA125	68,73	Vascular_endothelial_growth_factor	0,34	CA125	Vascular endothelial growth factor	94025	7422	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression correlates with serum CA125 and represents a useful tool in prediction of refractoriness to platinum-based chemotherapy and ascites formation in epithelial_ovarian_cancer .
1780685	0	CA125	61,66	tumor-associated_trypsin_inhibitor	14,48	CA125	tumor-associated trypsin inhibitor	94025	6690	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- with CA125 as a marker for diagnosis and monitoring of epithelial_ovarian_cancer .
11172033	0	CA150	45,50	huntingtin	66,76	CA150	huntingtin	10915	3064	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin : neuropathologic and genetic evidence for a role in Huntington 's _ disease pathogenesis .
10578054	0	CA150	70,75	p144	49,53	CA150	p144	56070(Tax:10090)	56070(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Molecular cloning and splicing isoforms of mouse p144 , a homologue of CA150 .
24385703	0	CA153	69,74	miR-21	31,37	CA153	miR-21	4582	406991	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of serum miR-21 in breast_cancer compared with CA153 and CEA .
3467786	0	CA19-9_and_CEA	68,82	CA125	22,27	CA19-9 and CEA	CA125	1084	94025	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Tumour marker antigen CA125 in pancreatic_cancer : a comparison with CA19-9_and_CEA .
11541960	0	CA2	51,54	ATPase	32,38	CA2	ATPase	760	1769	Gene	Gene	+|compound|START_ENTITY mitochondrial|nmod|+ mitochondrial|dobj|activity activity|amod|END_ENTITY	Modulation of oat mitochondrial ATPase activity by CA2 + and phytochrome .
3107918	0	CA2	42,45	carbonic_anhydrase_II	19,40	CA2	carbonic anhydrase II	760	760	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for human carbonic_anhydrase_II -LRB- CA2 -RRB- is located at chromosome 8q22 .
19225179	0	CA3	141,144	Galphao	56,63	CA3	Galphao	12350(Tax:10090)	14681(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A_adrenergic_receptor inhibition of mouse hippocampal CA3 epileptiform_activity .
9825961	0	CA3	58,61	GluR2	23,28	CA3	GluR2	761	2891	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Selective reduction of GluR2 protein in adult hippocampal CA3 neurons following status_epilepticus but prior to cell loss .
16970242	0	CA3	36,39	HSP70	0,5	CA3	HSP70	54232(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	HSP70 expression in the hippocampal CA3 subfield in different chronic stress models .
25209930	0	CA3	85,88	Mecp2	92,97	CA3	Mecp2	12350(Tax:10090)	17257(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice .
19225179	0	CA3	141,144	alpha2A_adrenergic_receptor	81,108	CA3	alpha2A adrenergic receptor	12350(Tax:10090)	11551(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A_adrenergic_receptor inhibition of mouse hippocampal CA3 epileptiform_activity .
15601941	0	CA3	161,164	brain-derived_neurotrophic_factor	16,49	CA3	brain-derived neurotrophic factor	12350(Tax:10090)	12064(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY inhibition|nmod|cells regulation|nmod|inhibition implies|dobj|regulation implies|nsubj|Localization Localization|nmod|END_ENTITY	Localization of brain-derived_neurotrophic_factor to distinct terminals of mossy fiber axons implies regulation of both excitation and feedforward inhibition of CA3 pyramidal cells .
16530956	0	CA3	87,90	brain-derived_neurotrophic_factor	16,49	CA3	brain-derived neurotrophic factor	12350(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	c-fos modulates brain-derived_neurotrophic_factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons .
24118418	0	CA3	100,103	brain-derived_neurotrophic_factor	9,42	CA3	brain-derived neurotrophic factor	761	627	Gene	Gene	neurons|compound|START_ENTITY hyperexcitability|nmod|neurons inhibits|dobj|hyperexcitability inhibits|nsubj|END_ENTITY	Blocking brain-derived_neurotrophic_factor inhibits injury-induced hyperexcitability of hippocampal CA3 neurons .
24755094	0	CA3	111,114	brain-derived_neurotrophic_factor	74,107	CA3	brain-derived neurotrophic factor	54232(Tax:10116)	24225(Tax:10116)	Gene	Gene	neurons|nummod|START_ENTITY increases|nmod|neurons increases|dobj|END_ENTITY	Exercise reduces diet-induced cognitive_decline and increases hippocampal brain-derived_neurotrophic_factor in CA3 neurons .
16530956	0	CA3	87,90	c-fos	0,5	CA3	c-fos	12350(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	c-fos modulates brain-derived_neurotrophic_factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons .
9651514	0	CA3	98,101	carbonic_anhydrase_3	76,96	CA3	carbonic anhydrase 3	761	761	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence comparisons and functional studies of the proximal promoter of the carbonic_anhydrase_3 -LRB- CA3 -RRB- gene .
10567219	0	CA6	40,43	carbonic_anhydrase_VI	17,38	CA6	carbonic anhydrase VI	765	765	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure of the carbonic_anhydrase_VI -LRB- CA6 -RRB- gene : evidence for two distinct groups within the alpha-CA gene family .
25447475	0	CA6	12,15	gustin	4,10	CA6	gustin	765	765	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The gustin -LRB- CA6 -RRB- gene polymorphism , rs2274333 -LRB- A/G -RRB- , is associated with fungiform_papilla density , whereas PROP bitterness is mostly due to TAS2R38 in an ethnically-mixed population .
17724612	0	CA9	22,25	Carbonic_anhydrase_9	0,20	CA9	Carbonic anhydrase 9	768	768	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Carbonic_anhydrase_9 -LRB- CA9 -RRB- expression in tumor cells enhances sensitivity to tirapazamine .
17852557	0	CA9	77,80	carbonic_anhydrase_9	55,75	CA9	carbonic anhydrase 9	768	768	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hypoxia inducible factor -LRB- HIf1alpha and HIF2alpha -RRB- and carbonic_anhydrase_9 -LRB- CA9 -RRB- expression and response of head-neck_cancer to hypofractionated and accelerated radiotherapy .
26252502	0	CA9	37,40	carbonic_anhydrase_IX	14,35	CA9	carbonic anhydrase IX	230099(Tax:10090)	230099(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of carbonic_anhydrase_IX -LRB- CA9 -RRB- sensitizes renal_cell_carcinoma to ionizing radiation .
26252502	0	CA9	37,40	carbonic_anhydrase_IX	14,35	CA9	carbonic anhydrase IX	230099(Tax:10090)	230099(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of carbonic_anhydrase_IX -LRB- CA9 -RRB- sensitizes renal_cell_carcinoma to ionizing radiation .
2510528	0	CAA	56,59	circulating_anodic_antigen	28,54	CAA	circulating anodic antigen	10194	10194	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of the schistosome circulating_anodic_antigen -LRB- CAA -RRB- in urine of patients with Schistosoma_mansoni or S. _ haematobium infections .
3793269	0	CAA	74,77	colon-associated_antigen	48,72	CAA	colon-associated antigen	10194	10194	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Immunological characterization of a novel human colon-associated_antigen -LRB- CAA -RRB- by a monoclonal antibody .
8985590	0	CAAF1	58,63	S100A12	30,37	CAAF1	S100A12	6283	6283	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the human S100A12 -LRB- calgranulin_C , p6 , CAAF1 , CGRP -RRB- gene , a new member of the S100 gene cluster on chromosome 1q21 .
21240291	0	CABYR	0,5	AKAP3	15,20	CABYR	AKAP3	26256	10566	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath .
23178685	0	CAC1	46,50	ERa	23,26	CAC1	ERa	113452	26284	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of ERa by a novel protein CAC1 through association with histone demethylase LSD1 .
24999833	0	CACN-1	0,6	Cactin	7,13	CACN-1	Cactin	175066(Tax:6239)	175066(Tax:6239)	Gene	Gene	START_ENTITY|appos|plays plays|nsubj|END_ENTITY	CACN-1 / Cactin plays a role in Wnt signaling in C. _ elegans .
27066515	0	CACNA1A	44,51	episodic_ataxia_type_2	70,92	CACNA1A	episodic ataxia type 2	773	773	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Next-generation sequencing identifies novel CACNA1A gene mutations in episodic_ataxia_type_2 .
24088670	0	CACT	66,70	carnitine-acylcarnitine_translocase	29,64	CACT	carnitine-acylcarnitine translocase	788	788	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Three novel mutations in the carnitine-acylcarnitine_translocase -LRB- CACT -RRB- gene in patients with CACT_deficiency and in healthy individuals .
10764577	0	CAD	17,20	caspase-activated_DNase	31,54	CAD	caspase-activated DNase	1677	1677	Gene	Gene	domain|compound|START_ENTITY Structure|nmod|domain Structure|nmod|END_ENTITY	Structure of the CAD domain of caspase-activated_DNase and interaction with the CAD domain of its inhibitor .
10764577	0	CAD	80,83	caspase-activated_DNase	31,54	CAD	caspase-activated DNase	1677	1677	Gene	Gene	domain|compound|START_ENTITY Structure|nmod|domain Structure|nmod|END_ENTITY	Structure of the CAD domain of caspase-activated_DNase and interaction with the CAD domain of its inhibitor .
15940676	0	CAD	32,35	caspase-activated_DNase	46,69	CAD	caspase-activated DNase	1677	1677	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Amyloid fibril formation by the CAD domain of caspase-activated_DNase .
23594158	0	CAD	15,18	mLST8	85,90	CAD	mLST8	730249	56716(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CAD , a multifunctional protein involved in pyrimidine synthesis , with mLST8 , a component of the mTOR complexes .
24727323	0	CADM1	0,5	CD7	48,51	CADM1	CD7	23705	924	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	CADM1 expression and stepwise downregulation of CD7 are closely associated with clonal expansion of HTLV-I-infected cells in adult_t-cell_leukemia / lymphoma .
23769722	0	CADM1	7,12	ErbB4	28,33	CADM1	ErbB4	54725(Tax:10090)	13869(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Necl-2 / CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons .
22528944	0	CADM1	53,58	MicroRNA-10b	0,12	CADM1	MicroRNA-10b	23705	406903	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular_carcinoma cells .
20215110	0	CADM1	0,5	Tiam1	21,26	CADM1	Tiam1	23705	7074	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell_leukemia virus type I-transformed cells and adult T-cell_leukemia cells .
22718847	0	CADM4	36,41	E-cadherin	93,103	CADM4	E-cadherin	199731	999	Gene	Gene	expression|compound|START_ENTITY significance|nmod|expression significance|nmod|END_ENTITY	Clinicopathological significance of CADM4 expression , and its correlation with expression of E-cadherin and Ki-67 in colorectal_adenocarcinomas .
23611113	0	CADM4	22,27	Necl-4	15,21	CADM4	Necl-4	199731	199731	Gene	Gene	Interaction|dep|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Necl-4 / CADM4 with ErbB3 and integrin a6 b4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly .
27015736	0	CAF	43,46	C-terminal_agrin_fragment	16,41	CAF	C-terminal agrin fragment	8850	8850	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of C-terminal_agrin_fragment -LRB- CAF -RRB- are associated with sarcopenia in older multimorbid community-dwellers : Results from the ilSIRENTE study .
21596687	0	CAF-1	39,44	AtCYP71	16,23	CAF-1	AtCYP71	8208	823585(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The cyclophilin AtCYP71 interacts with CAF-1 and LHP1 and functions in multiple chromatin remodeling processes .
19919826	0	CAF-1	20,25	p150	4,8	CAF-1	p150	10036	10036	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci .
19716330	0	CAF1	30,34	RISC	16,20	CAF1	RISC	8208	59342	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation .
20534591	0	CAGE	22,26	HDAC2	80,85	CAGE	HDAC2	168400	3066	Gene	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs .
26912082	0	CAGE	36,40	miR-30a	0,7	CAGE	miR-30a	168400	407029	Gene	Gene	Expression|nmod|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs .
3095084	0	CAII	43,47	carbonic_anhydrase_II	20,41	CAII	carbonic anhydrase II	12349(Tax:10090)	12349(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Early expression of carbonic_anhydrase_II -LRB- CAII -RRB- in transitory glial cells of the developing murine nervous system .
3122635	0	CAIII	55,60	muscle_specific_carbonic_anhydrase	19,53	CAIII	muscle specific carbonic anhydrase	761	761	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for human muscle_specific_carbonic_anhydrase -LRB- CAIII -RRB- is assigned to chromosome 8 .
15184875	0	CAIX	21,25	HIF-1alpha	38,48	CAIX	HIF-1alpha	768	3091	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Strict regulation of CAIX -LRB- G250/MN -RRB- by HIF-1alpha in clear_cell_renal_cell_carcinoma .
21691815	0	CAIX	41,45	carbonic_anhydrase_IX	18,39	CAIX	carbonic anhydrase IX	768	768	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of carbonic_anhydrase_IX -LRB- CAIX -RRB- is an independent unfavorable prognostic marker in endometrioid ovarian_cancer .
24471939	0	CAIX	37,41	carbonic_anhydrase_IX	14,35	CAIX	carbonic anhydrase IX	768	768	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of carbonic_anhydrase_IX -LRB- CAIX -RRB- in malignant_mesothelioma .
9368058	0	CAK	47,50	MAT1	69,73	CAK	MAT1	1022	4331	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	The cyclin-dependent kinase-activating kinase -LRB- CAK -RRB- assembly factor , MAT1 , targets and enhances CAK activity on the POU domains of octamer transcription factors .
10838081	0	CAKbeta	43,50	Hic-5	19,24	CAKbeta	Hic-5	2185	7041	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn .
24469636	0	CAL1	0,4	CENP-A	23,29	CAL1	CENP-A	42065(Tax:7227)	36495(Tax:7227)	Gene	Gene	factor|nsubj|START_ENTITY factor|compound|END_ENTITY	CAL1 is the Drosophila CENP-A assembly factor .
26151904	0	CAL1	69,73	CENP-A	46,52	CAL1	CENP-A	42065(Tax:7227)	36495(Tax:7227)	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription .
2968928	2	CALLA	114,119	CD43	102,106	CALLA	CD43	4311	6693	Gene	Gene	CD10|appos|START_ENTITY CD10|compound|END_ENTITY	Antibodies against CD45 -LRB- T200 -RRB- , CD3 -LRB- T3 -RRB- , CD43 , CD10 -LRB- CALLA -RRB- , transferrin receptor -LRB- T9 -RRB- , a novel broadly expressed 18-kDa antigen -LRB- MEM-43 -RRB- and a novel antigen of restricted expression -LRB- MEM-74 -RRB- .
2525226	0	CALLA	64,69	common_acute_lymphoblastic_leukaemia_antigen	18,62	CALLA	common acute lymphoblastic leukaemia antigen	4311	4311	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the common_acute_lymphoblastic_leukaemia_antigen -LRB- CALLA -RRB- in the human breast .
2415623	0	CALLA	63,68	common_acute_lymphoblastic_leukemia_antigen	18,61	CALLA	common acute lymphoblastic leukemia antigen	4311	4311	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the common_acute_lymphoblastic_leukemia_antigen -LRB- CALLA -RRB- on the surface of individual cells of human lymphoblastoid lines .
6339629	0	CALLA	59,64	common_acute_lymphoblastic_leukemia_antigen	14,57	CALLA	common acute lymphoblastic leukemia antigen	4311	4311	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of common_acute_lymphoblastic_leukemia_antigen -LRB- CALLA -RRB- on human malignant_melanoma cell lines .
2524403	0	CALLA	142,147	enkephalinase	20,33	CALLA	enkephalinase	4311	4311	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Characterisation of enkephalinase -LRB- EC 3.4.24.11 -RRB- activity on various leukemic cells expressing the common_acute_lymphocytic_leukemia_antigen -LRB- CALLA -RRB- .
1396581	0	CALLA	68,73	neutral_endopeptidase	36,57	CALLA	neutral endopeptidase	4311	4311	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Jurkat T cells express a functional neutral_endopeptidase activity -LRB- CALLA -RRB- involved in T cell activation .
22829078	0	CALM	20,24	FHL2	0,4	CALM	FHL2	8301	2274	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FHL2 interacts with CALM and is highly expressed in acute_erythroid_leukemia .
8314583	0	CALM1	53,58	CALM2	60,65	CALM1	CALM2	801	805	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Localization of the human bona fide calmodulin genes CALM1 , CALM2 , and CALM3 to chromosomes 14q24-q31 , 2p21.1-p21 .3 , and 19q13.2-q13 .3 .
9681195	0	CALM1	102,107	CALM2	30,35	CALM1	CALM2	801	805	Gene	Gene	activity|nmod|START_ENTITY gene|nmod|activity calmodulin|dobj|gene calmodulin|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1 , CALM2 and CALM3 .
8314583	0	CALM2	60,65	CALM1	53,58	CALM2	CALM1	805	801	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Localization of the human bona fide calmodulin genes CALM1 , CALM2 , and CALM3 to chromosomes 14q24-q31 , 2p21.1-p21 .3 , and 19q13.2-q13 .3 .
9681195	0	CALM2	30,35	CALM1	102,107	CALM2	CALM1	805	801	Gene	Gene	Characterization|nmod|START_ENTITY calmodulin|nsubj|Characterization calmodulin|dobj|gene gene|nmod|activity activity|nmod|END_ENTITY	Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1 , CALM2 and CALM3 .
25323779	0	CALR	62,66	Calreticulin	43,55	CALR	Calreticulin	811	811	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Frequency and Molecular Characteristics of Calreticulin Gene -LRB- CALR -RRB- Mutations in Patients with JAK2 _ - Negative_Myeloproliferative_Neoplasms .
24325359	0	CALR	8,12	JAK2	71,75	CALR	JAK2	811	3717	Gene	Gene	mutations|nsubj|START_ENTITY mutations|nmod|END_ENTITY	Somatic CALR mutations in myeloproliferative_neoplasms with nonmutated JAK2 .
14766228	0	CAN/Nup214	59,69	tristetraprolin	22,37	CAN/Nup214	tristetraprolin	8021	22695(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of tristetraprolin with the nucleoporin CAN/Nup214 .
12504025	0	CAND1	44,49	CUL1	22,26	CAND1	CUL1	55832	8454	Gene	Gene	p120|appos|START_ENTITY dissociates|dobj|p120 dissociates|nsubj|modification modification|nmod|END_ENTITY	NEDD8 modification of CUL1 dissociates p120 -LRB- CAND1 -RRB- , an inhibitor of CUL1-SKP1 binding and SCF ligases .
12504026	0	CAND1	0,5	CUL1	28,32	CAND1	CUL1	55832	8454	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex .
16036220	0	CAND1	0,5	CUL1	32,36	CAND1	CUL1	55832	8454	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|deneddylation deneddylation|nmod|END_ENTITY	CAND1 enhances deneddylation of CUL1 by COP9 signalosome .
1656060	0	CANP	38,42	Calcium-activated_neutral_proteinase	0,36	CANP	Calcium-activated neutral proteinase	823	823	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Calcium-activated_neutral_proteinase -LRB- CANP ; calpain -RRB- activity in Schwann cells : immunofluorescence localization and compartmentation of mu - and mCANP .
8393445	0	CAP-50	31,37	annexin_XI	19,29	CAP-50	annexin XI	311	311	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of annexin_XI -LRB- CAP-50 -RRB- in SR-3Y1 cells .
9573062	0	CAP18	76,81	cationic_antimicrobial_protein	44,74	CAP18	cationic antimicrobial protein	820	820	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Protective effects of a human 18-kilodalton cationic_antimicrobial_protein -LRB- CAP18 -RRB- - derived peptide against murine endotoxemia .
16179941	0	CAP3	12,16	CD95	20,24	CAP3	CD95	5272	355	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	The role of CAP3 in CD95 signaling : new insights into the mechanism of procaspase-8 activation .
9858899	0	CAPL	187,191	Interleukin-1_alpha	0,19	CAPL	Interleukin-1 alpha	6275	3552	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	Interleukin-1_alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis_associated_protein CAPL .
11334142	0	CAPL	65,69	S100A4	57,63	CAPL	S100A4	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Optimization of hammerhead ribozymes for the cleavage of S100A4 -LRB- CAPL -RRB- mRNA .
15523157	0	CAPN1	19,24	mu-calpain	7,17	CAPN1	mu-calpain	281661(Tax:9913)	281661(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Bovine mu-calpain -LRB- CAPN1 -RRB- gene : new SNP within intron 14 .
23687414	0	CAPN10	25,31	GAEC1	9,14	CAPN10	GAEC1	11132	100126794	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal_squamous_cell_carcinoma .
17855447	0	CAPN10	45,51	calpain-10	28,38	CAPN10	calpain-10	11132	11132	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variation in calpain-10 gene -LRB- CAPN10 -RRB- and diabetes risk in a multi-ethnic cohort of American postmenopausal women .
25327507	0	CAPN10	65,71	calpain_10	53,63	CAPN10	calpain 10	11132	11132	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A pharmacogenetic association between a variation in calpain_10 -LRB- CAPN10 -RRB- gene and the response to metformin treatment in patients with type 2 diabetes .
21713405	0	CAPN3	57,62	calpain-3	46,55	CAPN3	calpain-3	423233(Tax:9031)	423233(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the expression profile of calpain-3 -LRB- CAPN3 -RRB- gene in chicken .
17318636	0	CAPN3	66,71	calpain_3	50,59	CAPN3	calpain 3	825	825	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A large deletion and novel point mutations in the calpain_3 gene -LRB- CAPN3 -RRB- in Bulgarian LGMD2A patients .
23567141	0	CAPN3	50,55	calpain_3	34,43	CAPN3	calpain 3	443038(Tax:9940)	443038(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in exon 10 of the ovine calpain_3 gene -LRB- CAPN3 -RRB- and its association with meat yield in New Zealand Romney sheep .
19649723	0	CAPNS1	67,73	calpain_small_subunit	44,65	CAPNS1	calpain small subunit	281664(Tax:9913)	281664(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new SNP in the 3 ` UTR region of the bovine calpain_small_subunit -LRB- CAPNS1 -RRB- gene .
18234454	0	CAPNS1	76,82	calpain_small_subunit_1	51,74	CAPNS1	calpain small subunit 1	826	826	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	NRF-1 , and AP-1 regulate the promoter of the human calpain_small_subunit_1 -LRB- CAPNS1 -RRB- gene .
17565224	0	CAPON	53,58	NOS1AP	45,51	CAPON	NOS1AP	9722	9722	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations between genetic variants in the NOS1AP -LRB- CAPON -RRB- gene and cardiac repolarization in the old order Amish .
19077434	0	CAPON	35,40	NOS1AP	27,33	CAPON	NOS1AP	9722	9722	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence for a role of the NOS1AP -LRB- CAPON -RRB- gene in schizophrenia and its clinical dimensions : an association study in a South American population isolate .
25637021	0	CAPRI	44,49	CD28	0,4	CAPRI	CD28	10156	940	Gene	Gene	Adhesion|nmod|START_ENTITY Adhesion|compound|END_ENTITY	CD28 Inhibits T Cell Adhesion by Recruiting CAPRI to the Plasma Membrane .
20826818	0	CAPS	22,26	SNARE	100,105	CAPS	SNARE	8618	100170220	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Novel interactions of CAPS -LRB- Ca2 + - dependent_activator_protein_for_secretion -RRB- with the three neuronal SNARE proteins required for vesicle fusion .
26660684	0	CAR	23,26	CD19	18,22	CAR	CD19	12355(Tax:10090)	12478(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Murine allogeneic CD19 CAR T-cells harbor potent anti-leukemic activity but have the potential to mediate lethal GVHD .
17618724	0	CAR	54,57	CYP1A2	15,21	CAR	CYP1A2	12355(Tax:10090)	13077(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR .
16749864	0	CAR	54,57	CYP2C9	20,26	CAR	CYP2C9	9970	1559	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|promoter promoter|compound|END_ENTITY	Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver .
16799968	0	CAR	34,37	Constitutive_androstane_receptor	0,32	CAR	Constitutive androstane receptor	12355(Tax:10090)	12355(Tax:10090)	Gene	Gene	ligand|appos|START_ENTITY ligand|amod|END_ENTITY	Constitutive_androstane_receptor -LRB- CAR -RRB- ligand , TCPOBOP , attenuates Fas-induced murine liver_injury by altering Bcl-2 proteins .
16841169	0	CAR	45,48	Coxsackie-Adenovirus_receptor	14,43	CAR	Coxsackie-Adenovirus receptor	13052(Tax:10090)	13052(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Coxsackie-Adenovirus_receptor -LRB- CAR -RRB- in the developing mouse olfactory system .
15533241	0	CAR	70,73	Coxsackie_and_adenovirus_receptor	35,68	CAR	Coxsackie and adenovirus receptor	1525	1525	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Isoform-specific expression of the Coxsackie_and_adenovirus_receptor -LRB- CAR -RRB- in neuromuscular junction and cardiac intercalated discs .
16799975	0	CAR	101,104	HNF-4alpha	46,56	CAR	HNF-4alpha	12355(Tax:10090)	15378(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR .
23291559	0	CAR	17,20	Kcnk1	68,73	CAR	Kcnk1	12355(Tax:10090)	16525(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|gene gene|compound|END_ENTITY	Nuclear receptor CAR specifically activates the two-pore K + channel Kcnk1 gene in male mouse livers , which attenuates phenobarbital-induced hepatic_hyperplasia .
18713018	0	CAR	89,92	SF3a3	117,122	CAR	SF3a3	9970	10946	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Specific inhibition of transcriptional activity of the constitutive_androstane_receptor -LRB- CAR -RRB- by the splicing factor SF3a3 .
16167063	0	CAR	114,117	cFLIP	151,156	CAR	cFLIP	1525	8837	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	In vitro efficacy of AdTRAIL gene therapy of bladder_cancer is enhanced by trichostatin_A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL .
11075820	0	CAR	51,54	constitutive_active_receptor	56,84	CAR	constitutive active receptor	12355(Tax:10090)	12355(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Estrogen activation of the nuclear orphan receptor CAR -LRB- constitutive_active_receptor -RRB- in induction of the mouse Cyp2b10 gene .
24180433	0	CAR	167,170	constitutive_androstane_receptor	133,165	CAR	constitutive androstane receptor	9970	9970	Gene	Gene	activator|appos|START_ENTITY activator|compound|END_ENTITY	Mode of action and human relevance analysis for nuclear receptor-mediated liver_toxicity : A case study with phenobarbital as a model constitutive_androstane_receptor -LRB- CAR -RRB- activator .
24675475	0	CAR	155,158	constitutive_androstane_receptor	121,153	CAR	constitutive androstane receptor	12355(Tax:10090)	12355(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive_androstane_receptor -LRB- CAR -RRB- activation plays in their mode of action .
25069801	0	CAR	101,104	constitutive_androstane_receptor	67,99	CAR	constitutive androstane receptor	9970	9970	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Allyl_isothiocyanate -LRB- AITC -RRB- inhibits pregnane_X_receptor -LRB- PXR -RRB- and constitutive_androstane_receptor -LRB- CAR -RRB- activation and protects against acetaminophen - and amiodarone-induced cytotoxicity .
26275810	0	CAR	64,67	constitutive_androstane_receptor	30,62	CAR	constitutive androstane receptor	9970	9970	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Genome-wide analysis of human constitutive_androstane_receptor -LRB- CAR -RRB- transcriptome in wild-type and CAR-knockout HepaRG cells .
15761871	0	CAR	37,40	coxsackie_adenovirus_receptor	6,35	CAR	coxsackie adenovirus receptor	13052(Tax:10090)	13052(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Human coxsackie_adenovirus_receptor -LRB- CAR -RRB- expression in transgenic mouse prostate_tumors enhances adenoviral delivery of genes .
16014330	0	CAR	57,60	coxsackie_virus_and_adenovirus_receptor	16,55	CAR	coxsackie virus and adenovirus receptor	1525	1525	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of coxsackie_virus_and_adenovirus_receptor -LRB- CAR -RRB- in normal and regenerating human muscle .
26483283	0	CAR	48,51	coxsackievirus_and_adenovirus_receptor	8,46	CAR	coxsackievirus and adenovirus receptor	1525	1525	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Role of coxsackievirus_and_adenovirus_receptor -LRB- CAR -RRB- expression and viral load of adenovirus and enterovirus in patients with dilated_cardiomyopathy .
18303024	0	CAR	17,20	early_growth_response_1	30,53	CAR	early growth response 1	9970	1958	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	Nuclear receptor CAR requires early_growth_response_1 to activate the human cytochrome_P450_2B6 gene .
23539296	0	CAR	64,67	p38_Mitogen-activated_protein_kinase	0,36	CAR	p38 Mitogen-activated protein kinase	9970	1432	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p38_Mitogen-activated_protein_kinase regulates nuclear receptor CAR that activates the CYP2B6 gene .
24863965	0	CARD10	49,55	microRNA-146a	27,40	CARD10	microRNA-146a	29775	406938	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Lipopolysaccharide-induced microRNA-146a targets CARD10 and regulates angiogenesis in human umbilical vein endothelial cells .
21145487	0	CARD11	28,34	GAKIN	103,108	CARD11	GAKIN	84433	23303	Gene	Gene	distribution|nmod|START_ENTITY regulated|nsubjpass|distribution regulated|nmod|END_ENTITY	The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN .
11278692	0	CARD11	0,6	NF-kappa_B	160,170	CARD11	NF-kappa B	84433	4790	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	CARD11 and CARD14 are novel caspase recruitment domain -LRB- CARD -RRB- / membrane-associated guanylate kinase -LRB- MAGUK -RRB- family members that interact with BCL10 and activate NF-kappa_B .
26711259	0	CARD11	23,29	RNF181	94,100	CARD11	RNF181	84433	51255	Gene	Gene	Signaling|compound|START_ENTITY Regulation|nmod|Signaling Regulation|nmod|END_ENTITY	Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181 .
12360101	0	CARD15	92,98	NOD2	100,104	CARD15	NOD2	64127	64127	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Response to infliximab treatment in Crohn 's _ disease is not associated with mutations in the CARD15 -LRB- NOD2 -RRB- gene : an analysis in 534 patients from two multicenter , prospective GCP-level trials .
12671897	0	CARD15	61,67	NOD2	55,59	CARD15	NOD2	64127	64127	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	TNF-alpha and IFN-gamma regulate the expression of the NOD2 -LRB- CARD15 -RRB- gene in human intestinal epithelial cells .
12923865	0	CARD15	37,43	NOD2	45,49	CARD15	NOD2	64127	64127	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between mutations in the CARD15 -LRB- NOD2 -RRB- gene and Crohn 's _ disease in Israeli Jewish patients .
15479689	0	CARD15	6,12	NOD2	0,4	CARD15	NOD2	64127	64127	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	NOD2 -LRB- CARD15 -RRB- mutations in Crohn 's _ disease are associated with diminished mucosal alpha-defensin expression .
17719742	0	CARD15	103,109	NOD2	97,101	CARD15	NOD2	64127	64127	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification , evolution , and association study of a novel promoter and first exon of the human NOD2 -LRB- CARD15 -RRB- gene .
24385277	0	CARD8	14,19	ANRIL	34,39	CARD8	ANRIL	22900	100048912	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 -LRB- p.C10X -RRB- with ischemic_stroke .
18212821	0	CARD8	22,27	TUCAN	29,34	CARD8	TUCAN	22900	22900	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel isoforms of the CARD8 -LRB- TUCAN -RRB- gene evade a nonsense mutation .
12020527	0	CARD_15	21,28	NOD2	15,19	CARD 15	NOD2	64127	64127	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of NOD2 -LRB- CARD_15 -RRB- genotype with clinical course of Crohn 's _ disease : a cohort study .
20298285	0	CARD_15	94,101	caspase_activating_recruitment_domain_15	52,92	CARD 15	caspase activating recruitment domain 15	64127	64127	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Blau_syndrome-associated mutations in exon 4 of the caspase_activating_recruitment_domain_15 -LRB- CARD_15 -RRB- gene are not found in ethnic Danes with sarcoidosis .
14500758	0	CARM-1	151,157	SNF2-related_CBP_activator_protein	0,34	CARM-1	SNF2-related CBP activator protein	10498	10847	Gene	Gene	interactions|nmod|START_ENTITY END_ENTITY|nmod|interactions	SNF2-related_CBP_activator_protein -LRB- SRCAP -RRB- functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1 .
20360387	0	CARM1	0,5	estrogen_receptor_alpha	80,103	CARM1	estrogen receptor alpha	10498	2099	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen_receptor_alpha by cAMP .
18086859	0	CARMA1	47,53	Bcl10	76,81	CARMA1	Bcl10	84433	8915	Gene	Gene	phosphorylation|nmod|START_ENTITY contributes|nsubj|phosphorylation contributes|nmod|formation formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
18086859	0	CARMA1	69,75	Bcl10	76,81	CARMA1	Bcl10	84433	8915	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
18086859	0	CARMA1	47,53	CARMA1	69,75	CARMA1	CARMA1	84433	84433	Gene	Gene	phosphorylation|nmod|START_ENTITY contributes|nsubj|phosphorylation contributes|nmod|formation formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
18086859	0	CARMA1	69,75	CARMA1	47,53	CARMA1	CARMA1	84433	84433	Gene	Gene	formation|compound|START_ENTITY contributes|nmod|formation contributes|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
18086859	0	CARMA1	47,53	MALT1	82,87	CARMA1	MALT1	84433	10892	Gene	Gene	phosphorylation|nmod|START_ENTITY contributes|nsubj|phosphorylation contributes|nmod|formation formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
18086859	0	CARMA1	69,75	MALT1	82,87	CARMA1	MALT1	84433	10892	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
26206083	0	CARMA1	82,88	MiR-539	0,7	CARMA1	MiR-539	84433	664612	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-539 inhibits thyroid_cancer cell migration and invasion by directly targeting CARMA1 .
16508008	0	CARMA1	0,6	NF-kappaB	36,45	CARMA1	NF-kappaB	84433	4790	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	CARMA1 is required for Akt-mediated NF-kappaB activation in T cells .
19706536	0	CARMA1	19,25	NF-kappaB	50,59	CARMA1	NF-kappaB	84433	4790	Gene	Gene	Phosphorylation|nmod|START_ENTITY critical|nsubj|Phosphorylation critical|nmod|activation activation|amod|END_ENTITY	Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells .
12154356	0	CARMA1	18,24	NF-kappa_B	40,50	CARMA1	NF-kappa B	84433	4790	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|activation activation|amod|END_ENTITY	A requirement for CARMA1 in TCR-induced NF-kappa_B activation .
12154360	0	CARMA1	0,6	NF-kappa_B	68,78	CARMA1	NF-kappa B	84433	4790	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activation activation|amod|END_ENTITY	CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa_B activation .
12867038	0	CARMA1	16,22	NF-kappa_B	51,61	CARMA1	NF-kappa B	108723(Tax:10090)	18033(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Requirement for CARMA1 in antigen receptor-induced NF-kappa_B activation and lymphocyte proliferation .
14993411	0	CARMA1	63,69	NF-kappa_B	27,37	CARMA1	NF-kappa B	84433	4790	Gene	Gene	Determining|parataxis|START_ENTITY Determining|dobj|destiny destiny|nmod|END_ENTITY	Determining the destiny of NF-kappa_B after TCR ligation : it 's CARMA1 .
21041303	0	CARMA3	96,102	Bcl10	104,109	CARMA3	Bcl10	29775	8915	Gene	Gene	signalosome|compound|START_ENTITY signalosome|compound|END_ENTITY	Thrombin-dependent NF - -LCB- kappa -RCB- B activation and monocyte/endothelial adhesion are mediated by the CARMA3 Bcl10 MALT1 signalosome .
21041303	0	CARMA3	96,102	MALT1	111,116	CARMA3	MALT1	29775	10892	Gene	Gene	signalosome|compound|START_ENTITY signalosome|compound|END_ENTITY	Thrombin-dependent NF - -LCB- kappa -RCB- B activation and monocyte/endothelial adhesion are mediated by the CARMA3 Bcl10 MALT1 signalosome .
19046951	0	CART	14,18	CREB	41,45	CART	CREB	29131(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo .
26266486	0	CART	60,64	Cocaine_and_Amphetamine_Regulated_Transcript	14,58	CART	Cocaine and Amphetamine Regulated Transcript	397252(Tax:9823)	397252(Tax:9823)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Cocaine_and_Amphetamine_Regulated_Transcript -LRB- CART -RRB- in the Porcine Intramural Neurons of Stomach in the Course of Experimentally Induced Diabetes_Mellitus .
20595030	0	CART	47,51	ERK	71,74	CART	ERK	29131(Tax:10116)	24338(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide activates ERK pathways via NMDA receptors in rat spinal cord dorsal horn in an age-dependent manner .
10082837	0	CART	12,16	c-Fos	33,38	CART	c-Fos	29131(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour .
18314190	0	CART	49,53	c-Fos	113,118	CART	c-Fos	29131(Tax:10116)	314322(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY fraction|nmod|cells accumbens|nsubj|fraction accumbens|dobj|co-immunostain co-immunostain|nmod|END_ENTITY	Cocaine administration increases the fraction of CART cells in the rat nucleus accumbens that co-immunostain for c-Fos .
26475505	0	CART	19,23	c-fos	40,45	CART	c-fos	29131(Tax:10116)	314322(Tax:10116)	Gene	Gene	peptide|compound|START_ENTITY induces|nsubj|peptide induces|dobj|END_ENTITY	Fourth ventricular CART peptide induces c-fos in the area postrema and nucleus of the solitary tract via a CRF-receptor dependent mechanism .
20480461	0	CART	115,119	classification_and_regression_trees	78,113	CART	classification and regression trees	9607	9607	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Pain-specific diagnosis patterns in claims data - Identification by means of classification_and_regression_trees -LRB- CART -RRB- -RSB- .
16979766	0	CART	89,93	cocaine-amphetamine-regulated_transcript	47,87	CART	cocaine-amphetamine-regulated transcript	29131(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nicotine administration effects on feeding and cocaine-amphetamine-regulated_transcript -LRB- CART -RRB- expression in the hypothalamus .
10574510	0	CART	77,81	cocaine_and_amphetamine-regulated_transcript	31,75	CART	cocaine and amphetamine-regulated transcript	9607	9607	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence variants in the human cocaine_and_amphetamine-regulated_transcript -LRB- CART -RRB- gene in subjects with early onset obesity .
11602226	0	CART	77,81	cocaine_and_amphetamine-regulated_transcript	31,75	CART	cocaine and amphetamine-regulated transcript	29131(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The effect of adrenalectomy on cocaine_and_amphetamine-regulated_transcript -LRB- CART -RRB- expression in the hypothalamic nuclei of the rat .
20826136	0	CART	110,114	cocaine_and_amphetamine_regulated_transcript	64,108	CART	cocaine and amphetamine regulated transcript	29131(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of reboxetine and citalopram pretreatment on changes in cocaine_and_amphetamine_regulated_transcript -LRB- CART -RRB- expression in rat brain induced by the forced swimming test .
24174573	0	CART	103,107	cocaine_and_amphetamine_regulated_transcript	29,73	CART	cocaine and amphetamine regulated transcript	493726(Tax:9913)	493726(Tax:9913)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|xcomp|binding	Regulation of granulosa cell cocaine_and_amphetamine_regulated_transcript -LRB- CART -RRB- binding and effect of CART signaling inhibitor on granulosa cell estradiol production during dominant follicle selection in cattle .
22330621	0	CAS	24,27	CEA	89,92	CAS	CEA	9564	5670	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	Immediate conversion to CAS after neurological intolerance at cross-clamping test during CEA : a preliminary experience .
20020938	0	CAS	0,3	p53	43,46	CAS	p53	1434	7157	Gene	Gene	Accumulation|compound|START_ENTITY Accumulation|compound|END_ENTITY	CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis : Use of CAS for High-Sensitivity Anticancer Drug Screening .
23974298	0	CAS	0,3	vinculin	28,36	CAS	vinculin	9564	7414	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics .
9606285	0	CAS/gp330	77,86	Vitamin_D_receptor	0,18	CAS/gp330	Vitamin D receptor	9564;4036	7421	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Vitamin_D_receptor gene polymorphism and parathyroid calcium_sensor_protein -LRB- CAS/gp330 -RRB- expression in primary_hyperparathyroidism .
27012187	0	CASC11	20,26	hnRNP-K	42,49	CASC11	hnRNP-K	100270680	3190	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/b-catenin pathway to promote growth and metastasis in colorectal_cancer .
19096764	0	CASK	53,57	Acheron	0,7	CASK	Acheron	12361(Tax:10090)	67557(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Acheron , an novel LA antigen family member , binds to CASK and forms a complex with Id transcription factors .
22389404	0	CASK	0,4	Cx43	27,31	CASK	Cx43	8573	2697	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CASK -LRB- LIN2 -RRB- interacts with Cx43 in wounded skin and their coexpression affects cell migration .
26323380	0	CASP10	117,123	caspase-10	105,115	CASP10	caspase-10	843	843	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Autoimmune lymphoproliferative syndrome due to somatic FAS mutation -LRB- ALPS-sFAS -RRB- combined with a germline caspase-10 -LRB- CASP10 -RRB- variation .
26323380	0	CASP10	117,123	caspase-10	105,115	CASP10	caspase-10	843	843	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Autoimmune lymphoproliferative syndrome due to somatic FAS mutation -LRB- ALPS-sFAS -RRB- combined with a germline caspase-10 -LRB- CASP10 -RRB- variation .
11393657	0	CASP9	60,65	Caspase-9	49,58	CASP9	Caspase-9	842	842	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Two novel single-nucleotide polymorphisms of the Caspase-9 -LRB- CASP9 -RRB- gene in the Japanese population .
11677110	0	CASP9	52,57	caspase-9	41,50	CASP9	caspase-9	842	842	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The potential tumour suppressor role for caspase-9 -LRB- CASP9 -RRB- in the childhood malignancy , neuroblastoma .
15561962	0	CASQ1	37,42	calsequestrin_1	20,35	CASQ1	calsequestrin 1	844	844	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the calsequestrin_1 -LRB- CASQ1 -RRB- gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish .
20164288	0	CASR	26,30	Calcium-sensing_receptor	0,24	CASR	Calcium-sensing receptor	846	846	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Calcium-sensing_receptor -LRB- CASR -RRB- mutations in hypercalcemic states : studies from a single endocrine clinic over three years .
11668634	0	CASR	66,70	calcium-sensing_receptor	40,64	CASR	calcium-sensing receptor	846	846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An acceptor splice site mutation in the calcium-sensing_receptor -LRB- CASR -RRB- gene in familial_hypocalciuric_hypercalcemia and neonatal_severe_hyperparathyroidism .
25594051	1	CASS4	74,79	NEDD9	67,72	CASS4	NEDD9	57091	4739	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	The cancer signaling proteins NEDD9 , CASS4 , and PTK2B in Alzheimer 's _ disease .
23951044	0	CAST	18,22	Calpastatin	0,11	CAST	Calpastatin	831	831	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Calpastatin gene -LRB- CAST -RRB- is not associated with late onset sporadic_Parkinson 's _ disease in the Han Chinese population .
19812333	0	CAST	102,106	Munc13-1	153,161	CAST	Munc13-1	831	23025	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	A protein interaction node at the neurotransmitter release site : domains of Aczonin/Piccolo , Bassoon , CAST , and rim converge on the N-terminal domain of Munc13-1 .
18802795	0	CAST	51,55	calpastatin	38,49	CAST	calpastatin	443364(Tax:9940)	443364(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Haplotypic diversity within the ovine calpastatin -LRB- CAST -RRB- gene .
22062769	0	CAST	49,53	calpastatin	36,47	CAST	calpastatin	281039(Tax:9913)	281039(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Allelic polymorphism of the caprine calpastatin -LRB- CAST -RRB- gene identified by PCR-SSCP .
24200570	0	CAST	57,61	calpastatin	44,55	CAST	calpastatin	831	831	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new single nucleotide polymorphism in the calpastatin -LRB- CAST -RRB- gene associated with beef tenderness .
20301895	0	CAT	89,92	GPX1	101,105	CAT	GPX1	847	2876	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
24711484	0	CAT	48,51	GPX1	53,57	CAT	GPX1	847	2876	Gene	Gene	GPX4|appos|START_ENTITY GPX4|appos|END_ENTITY	Plasma antioxidants , genetic variation in SOD2 , CAT , GPX1 , GPX4 , and prostate_cancer survival .
25033027	0	CAT	73,76	GPX1	43,47	CAT	GPX1	847	2876	Gene	Gene	C-262T|compound|START_ENTITY glutathione_peroxidase_1|appos|C-262T glutathione_peroxidase_1|appos|Pro198Leu Pro198Leu|nummod|END_ENTITY	Polymorphisms of glutathione_peroxidase_1 -LRB- GPX1 Pro198Leu -RRB- and catalase -LRB- CAT C-262T -RRB- in women with spontaneous_abortion .
25436036	0	CAT	0,3	GPX1	5,9	CAT	GPX1	847	2876	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
20445800	0	CAT	81,84	GSTM1	67,72	CAT	GSTM1	847	2944	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
25436036	0	CAT	0,3	GSTM1	18,23	CAT	GSTM1	847	2944	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
20445800	0	CAT	81,84	GSTT1	74,79	CAT	GSTT1	847	2952	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
26674569	0	CAT	69,72	Gpx1	36,40	CAT	Gpx1	847	2876	Gene	Gene	C/T|nmod|START_ENTITY Pro197Leu|appos|C/T Pro197Leu|nmod|END_ENTITY	Genetic polymorphisms -LRB- Pro197Leu of Gpx1 , +35 A/C of SOD1 , -262 C/T of CAT -RRB- , the level of antioxidant proteins -LRB- GPx1 , SOD1 , CAT -RRB- and the risk of distal_symmetric_polyneuropathy in Polish patients with type_2_diabetes_mellitus .
15705913	0	CAT	64,67	MnSOD	57,62	CAT	MnSOD	847	6648	Gene	Gene	MPO|dep|START_ENTITY MPO|dep|END_ENTITY	Polymorphisms in genes related to oxidative stress -LRB- MPO , MnSOD , CAT -RRB- and survival after treatment for breast_cancer .
20301895	0	CAT	89,92	MnSOD	94,99	CAT	MnSOD	847	6648	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|GPX1 GPX1|compound|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20445800	0	CAT	81,84	MnSOD	86,91	CAT	MnSOD	847	6648	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
25436036	0	CAT	0,3	MnSOD	11,16	CAT	MnSOD	847	6648	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
23868633	0	CAT	33,36	catalase	23,31	CAT	catalase	847	847	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No association between catalase -LRB- CAT -RRB- gene polymorphisms and susceptibility to vitiligo in a Turkish population .
25139332	0	CAT	80,83	catalase	70,78	CAT	catalase	847	847	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between the 389C > T polymorphism -LRB- rs769217 -RRB- in the catalase -LRB- CAT -RRB- gene and the risk of vitiligo : An update by meta-analysis .
6252821	0	CAT	33,36	catalase	23,31	CAT	catalase	847	847	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regional assignment of catalase -LRB- CAT -RRB- gene to band 11p13 .
9760750	0	CAT	63,66	chloramphenicol_acetyltransferase	28,61	CAT	chloramphenicol acetyltransferase	8319152(Tax:562)	8319152(Tax:562)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The low level expression of chloramphenicol_acetyltransferase -LRB- CAT -RRB- mRNA in Escherichia_coli is not dependent on either Shine-Dalgarno or the downstream boxes in the CAT gene .
9427394	0	CAT8	98,102	ACS1	65,69	CAT8	ACS1	855323(Tax:4932)	851245(Tax:4932)	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Transcriptional control of the yeast acetyl-CoA synthetase gene , ACS1 , by the positive regulators CAT8 and ADR1 and the pleiotropic repressor UME6 .
24130856	0	CATP-6	0,6	GEM-1	69,74	CATP-6	GEM-1	177822(Tax:6239)	181458(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	CATP-6 , a C. _ elegans ortholog of ATP13A2 PARK9 , positively regulates GEM-1 , an SLC16A transporter .
25538703	0	CAV1	93,97	CD4	101,104	CAV1	CD4	857	920	Gene	Gene	START_ENTITY|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Design , Assessment , and in vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4 -LRB- + -RRB- T-lymphocytes .
3478118	0	CA_125	53,59	CA_125	78,84	CA 125	CA 125	94025	94025	Gene	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Explanation of the limited correlation between tumor CA_125 content and serum CA_125 antigen levels in patients with ovarian_tumors .
3478118	0	CA_125	78,84	CA_125	53,59	CA 125	CA 125	94025	94025	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|dobj|levels	Explanation of the limited correlation between tumor CA_125 content and serum CA_125 antigen levels in patients with ovarian_tumors .
2646183	0	CA_125	21,27	CA_19-9_and_CEA	107,122	CA 125	CA 19-9 and CEA	94025	1084	Gene	Gene	expression|nmod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	Tissue expression of CA_125 in benign and malignant lesions of ovary_and_fallopian_tube : a comparison with CA_19-9_and_CEA .
16996112	0	CA_125	33,39	MMP-2	0,5	CA 125	MMP-2	94025	4313	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	MMP-2 expression associates with CA_125 and clinical course in endometrial_carcinoma .
2452770	0	CA_125	32,38	cancer_antigen_125	12,30	CA 125	cancer antigen 125	94025	94025	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of cancer_antigen_125 -LRB- CA_125 -RRB- in the management_of_ovarian_epithelial_carcinomas .
3864535	0	CA_125	45,51	cancer_antigen_125	25,43	CA 125	cancer antigen 125	94025	94025	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of cancer_antigen_125 -LRB- CA_125 -RRB- in ovarian_cancer .
2255409	0	CA_15-3	1,8	CEA	25,28	CA 15-3	CEA	4582	1084	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	-LSB- CA_15-3 associated with CEA and TPA in the follow-up of breast_carcinoma -RSB- .
2733831	0	CA_15-3	1,8	CEA	94,97	CA 15-3	CEA	4582	1084	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- CA_15-3 in the diagnosis and monitoring of carcinoma_of_the_breast and its correlations with CEA -RSB- .
2646183	0	CA_19-9_and_CEA	107,122	CA_125	21,27	CA 19-9 and CEA	CA 125	1084	94025	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|nmod|END_ENTITY	Tissue expression of CA_125 in benign and malignant lesions of ovary_and_fallopian_tube : a comparison with CA_19-9_and_CEA .
3099305	0	CA_III	41,47	carbonic_anhydrase_III	17,39	CA III	carbonic anhydrase III	761	761	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of human carbonic_anhydrase_III -LRB- CA_III -RRB- on synovial and muscle fibroblast glycosaminoglycan metabolism .
15500001	0	CA_III	33,39	leptin	11,17	CA III	leptin	54232(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of leptin and insulin on CA_III expression in rat adipose tissue .
15752902	0	CA_IX	43,48	carbonic_anhydrase_IX	20,41	CA IX	carbonic anhydrase IX	768	768	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of carbonic_anhydrase_IX -LRB- CA_IX -RRB- as an endogenous marker of chronic hypoxia in live human tumor cells .
18180112	1	CA_IX	154,159	carbonic_anhydrase_IX	131,152	CA IX	carbonic anhydrase IX	768	768	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A simulation study of the hypoxia marker carbonic_anhydrase_IX -LRB- CA_IX -RRB- in human soft tissue sarcoma .
24436269	0	CA_IX	59,64	carbonic_anhydrase_IX	36,57	CA IX	carbonic anhydrase IX	768	768	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Immunohistochemical reevaluation of carbonic_anhydrase_IX -LRB- CA_IX -RRB- expression in tumors and normal tissues .
11841893	0	CB1	17,20	CNR1	48,52	CB1	CNR1	1268	1268	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of a CB1 cannabinoid receptor gene -LRB- CNR1 -RRB- polymorphism with severe alcohol_dependence .
21633404	0	CB1	41,44	CNR1	51,55	CB1	CNR1	1268	1268	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variants at the endocannabinoid receptor CB1 gene -LRB- CNR1 -RRB- and insulin sensitivity , type_2_diabetes , and coronary_heart_disease .
23023167	0	CB1	45,48	CYP2E1	67,73	CB1	CYP2E1	12801(Tax:10090)	13106(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Estrogen-related receptor y controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver_injury by alcohol .
12562514	0	CB1	12,15	Cannabinoid	0,11	CB1	Cannabinoid	12801(Tax:10090)	12801(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary_alcohol_consumption and lack alcohol-induced dopamine release in the nucleus accumbens .
19033531	0	CB1	15,18	Cannabinoid-1	0,13	CB1	Cannabinoid-1	12801(Tax:10090)	12801(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Cannabinoid-1 -LRB- CB1 -RRB- receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon .
12690115	0	CB1	113,116	Orexin_1_receptor	26,43	CB1	Orexin 1 receptor	1268	3061	Gene	Gene	antagonist|compound|START_ENTITY blocked|nmod|antagonist cross-talk|acl|blocked evidence|nmod|cross-talk Hypersensitization|dep|evidence Hypersensitization|nmod|END_ENTITY	Hypersensitization of the Orexin_1_receptor by the CB1 receptor : evidence for cross-talk blocked by the specific CB1 antagonist , SR141716 .
12690115	0	CB1	51,54	Orexin_1_receptor	26,43	CB1	Orexin 1 receptor	1268	3061	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Hypersensitization of the Orexin_1_receptor by the CB1 receptor : evidence for cross-talk blocked by the specific CB1 antagonist , SR141716 .
17384224	0	CB1	53,56	Ser2	32,36	CB1	Ser2	1268	3714	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Mutation studies of Ser7 .39 and Ser2 .60 in the human CB1 cannabinoid receptor : evidence for a serine-induced bend in CB1 transmembrane helix 7 .
16647109	0	CB1	30,33	TRPV1	8,13	CB1	TRPV1	25248(Tax:10116)	83810(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Role of TRPV1 and cannabinoid CB1 receptors in AM_404-evoked hypothermia in rats .
18936104	0	CB1	61,64	TRPV1	33,38	CB1	TRPV1	25248(Tax:10116)	83810(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|vanilloid vanilloid|dep|END_ENTITY	Reciprocal changes in vanilloid -LRB- TRPV1 -RRB- and endocannabinoid -LRB- CB1 -RRB- receptors contribute to visceral_hyperalgesia in the water avoidance stressed rat .
18987195	0	CB1	159,162	TRPV1	125,130	CB1	TRPV1	12801(Tax:10090)	193034(Tax:10090)	Gene	Gene	agonists|nummod|START_ENTITY actions|nmod|agonists stimulation|dep|actions stimulation|nmod|END_ENTITY	Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1 : antinociceptive actions of CB1 inverse agonists .
18987195	0	CB1	41,44	TRPV1	125,130	CB1	TRPV1	12801(Tax:10090)	193034(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY activity|nmod|receptor required|nsubjpass|activity required|nmod|stimulation stimulation|nmod|END_ENTITY	Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1 : antinociceptive actions of CB1 inverse agonists .
20619260	0	CB1	78,81	TRPV1	129,134	CB1	TRPV1	1268	7442	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Epidermal_growth_factor_receptor transactivation by the cannabinoid receptor -LRB- CB1 -RRB- and transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- induces differential responses in corneal epithelial cells .
22325096	0	CB1	27,30	TRPV1	50,55	CB1	TRPV1	25248(Tax:10116)	83810(Tax:10116)	Gene	Gene	CB2|compound|START_ENTITY antagonists|compound|CB2 antagonists|compound|END_ENTITY	The effects of cannabinoid CB1 , CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats .
23850608	0	CB1	0,3	TRPV1	71,76	CB1	TRPV1	1268	7442	Gene	Gene	agonist|nummod|START_ENTITY prevents|nsubj|agonist prevents|dobj|sensitization sensitization|nmod|END_ENTITY	CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons .
25088915	0	CB1	14,17	TRPV1	56,61	CB1	TRPV1	12801(Tax:10090)	193034(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY inhibits|nsubj|Activation inhibits|dobj|sensitization sensitization|nmod|END_ENTITY	Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons .
26496209	0	CB1	25,28	WAVE1	48,53	CB1	WAVE1	12801(Tax:10090)	83767(Tax:10090)	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons .
14522843	0	CB1	54,57	c-Jun_N-terminal_kinase	76,99	CB1	c-Jun N-terminal kinase	25248(Tax:10116)	116554(Tax:10116)	Gene	Gene	activation|nummod|START_ENTITY activation|amod|END_ENTITY	Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun_N-terminal_kinase activation in cultured cortical neurons .
10394995	0	CB1	25,28	cannabinoid	12,23	CB1	cannabinoid	1268	1268	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Blockade of cannabinoid -LRB- CB1 -RRB- receptors by 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils .
16639008	0	CB1	55,58	cannabinoid	42,53	CB1	cannabinoid	1268	1268	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Noladin_ether acts on trabecular meshwork cannabinoid -LRB- CB1 -RRB- receptors to enhance aqueous humor outflow facility .
16440297	0	CB1	41,44	cannabinoid-1	26,39	CB1	cannabinoid-1	25248(Tax:10116)	25248(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Targeting dopamine D2 and cannabinoid-1 -LRB- CB1 -RRB- receptors in rat nucleus accumbens .
19130142	0	CB1	61,64	cannabinoid-1	46,59	CB1	cannabinoid-1	574142(Tax:9544)	574142(Tax:9544)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	PET imaging studies in rhesus_monkey with the cannabinoid-1 -LRB- CB1 -RRB- receptor ligand -LSB- 11C -RSB- CB-119 .
21075633	0	CB1	59,62	cannabinoid-1	44,57	CB1	cannabinoid-1	1268	1268	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 -LRB- CB1 -RRB- antagonists : journey from non-polar to polar amides .
21741835	0	CB1	103,106	cannabinoid-1	88,101	CB1	cannabinoid-1	12801(Tax:10090)	12801(Tax:10090)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Structure-activity relationship studies of novel pyrazole and imidazole_carboxamides as cannabinoid-1 -LRB- CB1 -RRB- antagonists .
16563642	0	CB1	20,23	cannabinoid_receptor	24,44	CB1	cannabinoid receptor	1268	1268	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization of CB1 cannabinoid_receptor immunoreactivity in postmortem human brain homogenates .
21472841	0	CB1	61,64	cannabinoid_receptor	39,59	CB1	cannabinoid receptor	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relation of G1359A polymorphism of the cannabinoid_receptor -LRB- CB1 -RRB- gene with metabolic_syndrome by ATP III classification .
24182233	0	CB1	128,131	cannabinoid_receptor	106,126	CB1	cannabinoid receptor	1268	1268	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid_receptor -LRB- CB1 -RRB- antagonists with desired pharmacokinetic properties .
21875798	0	CB1	51,54	cannabinoid_receptor_1	27,49	CB1	cannabinoid receptor 1	1268	1268	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Towards rational design of cannabinoid_receptor_1 -LRB- CB1 -RRB- antagonists for peripheral selectivity .
17217945	0	CB1	120,123	fatty_acid_amide_hydrolase	77,103	CB1	fatty acid amide hydrolase	12801(Tax:10090)	14073(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Assessment of anandamide 's pharmacological effects in mice deficient_of_both fatty_acid_amide_hydrolase and cannabinoid CB1 receptors .
21175570	0	CB1	49,52	fatty_acid_amide_hydrolase	14,40	CB1	fatty acid amide hydrolase	12801(Tax:10090)	14073(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY unmasks|dobj|receptor unmasks|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of fatty_acid_amide_hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey .
22532145	0	CB1	33,36	ghrelin	62,69	CB1	ghrelin	25248(Tax:10116)	59301(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|nmod|END_ENTITY	Effects of CP 55,940 -- agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas .
22789143	0	CB1-R	78,83	cannabinoid_receptor_type_1	49,76	CB1-R	cannabinoid receptor type 1	1268	1268	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Progesterone-dependent regulation of endometrial cannabinoid_receptor_type_1 -LRB- CB1-R -RRB- expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
16781706	0	CB2	22,25	AM1241	0,6	CB2	AM1241	12802(Tax:10090)	3171117(Tax:234826)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	AM1241 , a cannabinoid CB2 receptor selective compound , delays disease progression in a mouse model of amyotrophic_lateral_sclerosis .
24361916	0	CB2	60,63	MDA7	73,77	CB2	MDA7	57302(Tax:10116)	170819(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	Spinal gene expression profiling and pathways analysis of a CB2 agonist -LRB- MDA7 -RRB- - targeted prevention of paclitaxel-induced neuropathy .
15556647	0	CB2	82,85	TNF-alpha	31,40	CB2	TNF-alpha	1269	7124	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways .
22325096	0	CB2	32,35	TRPV1	50,55	CB2	TRPV1	57302(Tax:10116)	83810(Tax:10116)	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	The effects of cannabinoid CB1 , CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats .
12663043	0	CB2	103,106	cannabinoid-2	88,101	CB2	cannabinoid-2	1269	1269	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Effects of D3 .49 A , R3 .50 A , and A6 .34 E mutations on ligand binding and activation of the cannabinoid-2 -LRB- CB2 -RRB- receptor .
19552692	0	CB2	40,43	cannabinoid-2	25,38	CB2	Cannabinoid-2	1269	1269	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Constitutive activity of cannabinoid-2 -LRB- CB2 -RRB- receptors plays an essential role in the protean agonism of -LRB- + -RRB- AM1241 and L768242 .
17539892	0	CB2	33,36	cannabinoid_2	18,31	CB2	cannabinoid 2	12802(Tax:10090)	12802(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Activation of the cannabinoid_2 -LRB- CB2 -RRB- receptor inhibits murine mesenteric afferent nerve activity .
18270474	0	CB2	53,56	cannabinoid_2	38,51	CB2	cannabinoid 2	57302(Tax:10116)	57302(Tax:10116)	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Pharmacological evaluation of a novel cannabinoid_2 -LRB- CB2 -RRB- ligand , PF-03550096 , in vitro and in vivo by using a rat model of visceral_hypersensitivity .
22371074	0	CB2	28,31	cannabinoid_2	13,26	CB2	cannabinoid 2	1269	1269	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Interplay of cannabinoid_2 -LRB- CB2 -RRB- receptors with nitric_oxide synthases , oxidative and nitrative stress , and cell death during remote neurodegeneration .
21626285	0	CB2	55,58	cannabinoid_receptor_2	31,53	CB2	cannabinoid receptor 2	1269	1269	Gene	Gene	regulation|compound|START_ENTITY regulation|amod|END_ENTITY	Unraveling the complexities of cannabinoid_receptor_2 -LRB- CB2 -RRB- immune regulation in health and disease .
17118807	0	CB2	59,62	cannabinoid_type-2	39,57	CB2	cannabinoid type-2	1269	1269	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	New natural noncannabinoid ligands for cannabinoid_type-2 -LRB- CB2 -RRB- receptors .
22198001	0	CB2	40,43	nNOS	23,27	CB2	nNOS	1269	4842	Gene	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor regulation|nmod|END_ENTITY	Distinct regulation of nNOS and iNOS by CB2 receptor in remote delayed neurodegeneration .
15247148	0	CBF-1	110,115	RBP-Jk	116,122	CBF-1	RBP-Jk	3516	3516	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Notch 1 and 3 receptor signaling modulates vascular smooth_muscle_cell growth , apoptosis , and migration via a CBF-1 / RBP-Jk dependent pathway .
8754798	0	CBF-A	178,183	CBF-B	133,138	CBF-A	CBF-B	4800	865	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Determination of functional domains in the C subunit of the CCAAT-binding factor -LRB- CBF -RRB- necessary for formation of a CBF-DNA complex : CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule .
8754798	0	CBF-B	133,138	CBF-A	178,183	CBF-B	CBF-A	865	4800	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Determination of functional domains in the C subunit of the CCAAT-binding factor -LRB- CBF -RRB- necessary for formation of a CBF-DNA complex : CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule .
23988114	0	CBF-b	77,82	Vif	94,97	CBF-b	Vif	865	155459(Tax:11676)	Gene	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-b binding to Vif .
12200447	0	CBF1	26,30	C/EBP	11,16	CBF1	C/EBP	3516	1050	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of C/EBP and RBP -LRB- CBF1 -RRB- to overlapping sites regulates interleukin-6 gene expression .
15652350	0	CBF1	22,26	CIR	0,3	CBF1	CIR	3516	9541	Gene	Gene	corepressor|nmod|START_ENTITY END_ENTITY|appos|corepressor	CIR , a corepressor of CBF1 , binds to PAP-1 and effects alternative splicing .
8643633	0	CBF1	69,73	Notch1	28,34	CBF1	Notch1	3516	4851	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element .
17712600	0	CBF5	12,16	NAF1	65,69	CBF5	NAF1	850872(Tax:4932)	855599(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1 .
11165321	0	CBFA2	26,31	AML1	21,25	CBFA2	AML1	861	861	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Amplification of the AML1 -LRB- CBFA2 -RRB- gene on ring chromosomes in a patient with acute_myeloid_leukemia and a constitutional ring chromosome 21 .
16966434	0	CBFA2T3	89,96	ZNF652	0,6	CBFA2T3	ZNF652	863	22834	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ZNF652 , a novel zinc finger protein , interacts with the putative breast_tumor suppressor CBFA2T3 to repress transcription .
9862705	0	CBF_alpha3	0,10	TGF-beta1	32,41	CBF alpha3	TGF-beta1	12399(Tax:10090)	21803(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	CBF_alpha3 -LRB- AML2 -RRB- is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter .
11276260	0	CBF_beta	38,46	AML1	24,28	CBF beta	AML1	865	861	Gene	Gene	functions|compound|START_ENTITY END_ENTITY|dep|functions	The leukemia-associated AML1 -LRB- Runx1 -RRB- -- CBF_beta complex functions as a DNA-induced molecular clamp .
23333304	0	CBFb	0,4	Vif	20,23	CBFb	Vif	865	155459(Tax:11676)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	CBFb stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression .
6812601	0	CBG	94,97	transcortin	81,92	CBG	transcortin	866	866	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Immunoglobulin levels in breast cyst fluid : apparent connection with intracystic transcortin -LRB- CBG -RRB- binding activity .
9195915	0	CBL	16,19	BCR-ABL	25,32	CBL	BCR-ABL	867	25	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of CBL with BCR-ABL and CRKL in BCR-ABL-transformed myeloid cells .
11857085	0	CBL	41,44	BCR/ABL	58,65	CBL	BCR/ABL	12402(Tax:10090)	110279;11350	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells .
22489043	0	CBL	28,31	DNMT3A	33,39	CBL	DNMT3A	867	1788	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
9529123	0	CBL	47,50	FLT3	0,4	CBL	FLT3	867	2322	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|END_ENTITY	FLT3 signaling in hematopoietic cells involves CBL , SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates .
22489043	0	CBL	28,31	IDH1	41,45	CBL	IDH1	867	3417	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	CBL	28,31	IDH2	47,51	CBL	IDH2	867	3418	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	CBL	28,31	JAK2	53,57	CBL	JAK2	867	3717	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
23696637	0	CBL	0,3	JAK2	152,156	CBL	KRAS	867	3845	Gene	Gene	region|compound|START_ENTITY lead|nsubj|region lead|nmod|granulocyte-macrophage_colony-stimulating_factor granulocyte-macrophage_colony-stimulating_factor|acl|signaling signaling|nmod|levels levels|nmod|END_ENTITY	CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- signaling via elevated levels of JAK2 and LYN .
22489043	0	CBL	28,31	MPL	59,62	CBL	MPL	867	4352	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	CBL	28,31	NF1	64,67	CBL	NF1	867	4763	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	CBL	28,31	SF3B1	69,74	CBL	SF3B1	867	23451	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
25691332	0	CBL-B	116,121	miR-30e	29,36	CBL-B	miR-30e	868	407034	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Ionizing radiation-inducible miR-30e promotes glioma cell invasion through EGFR stabilization by directly targeting CBL-B .
23331977	0	CBL10	27,32	AKT1	57,61	CBL10	AKT1	829437(Tax:3702)	817206(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Calcineurin_B-like protein CBL10 directly interacts with AKT1 and modulates K + homeostasis in Arabidopsis .
11390628	0	CBP	64,67	BRLF1	43,48	CBP	BRLF1	1387	17494186	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Epstein-Barr_virus immediate-early protein BRLF1 interacts with CBP , promoting enhanced BRLF1 transactivation .
11390628	0	CBP	64,67	BRLF1	88,93	CBP	BRLF1	1387	17494186	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|promoting promoting|dobj|transactivation transactivation|compound|END_ENTITY	Epstein-Barr_virus immediate-early protein BRLF1 interacts with CBP , promoting enhanced BRLF1 transactivation .
20930143	0	CBP	43,46	CLOCK-BMAL1	20,31	CBP	CLOCK-BMAL1	1387	9575;406	Gene	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock .
16339753	0	CBP	129,132	CREB	87,91	CBP	CREB	1387	1385	Gene	Gene	facilitating|nmod|START_ENTITY facilitating|dobj|coactivation coactivation|compound|END_ENTITY	The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP .
16761278	0	CBP	142,145	CREB	88,92	CBP	CREB	1387	1385	Gene	Gene	domain|nmod|START_ENTITY facilitates|nmod|domain facilitates|nsubj|structure structure|nmod|domain domain|nmod|END_ENTITY	Phosphorylation-induced transient intrinsic structure in the kinase-inducible domain of CREB facilitates its recognition by the KIX domain of CBP .
17476304	0	CBP	33,36	CREB	69,73	CBP	CREB	1387	1385	Gene	Gene	interactions|nmod|START_ENTITY confer|nsubj|interactions confer|nmod|expression expression|amod|END_ENTITY	Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression .
23768074	0	CBP	29,32	CREB	33,37	CBP	CREB	1387	1385	Gene	Gene	contribution|nmod|START_ENTITY contribution|dep|END_ENTITY	Differential contribution of CBP : CREB binding to corticotropin-releasing_hormone expression in the infant and adult hypothalamus .
24338025	0	CBP	76,79	CREB	27,31	CBP	CREB	1387	1385	Gene	Gene	proteins|appos|START_ENTITY scaffolded|nmod|proteins protein|acl|scaffolded protein|compound|END_ENTITY	NF-kB and enhancer-binding CREB protein scaffolded by CREB-binding_protein -LRB- CBP -RRB- / p300 proteins regulate CD59 protein expression to protect cells from complement attack .
8413673	0	CBP	62,65	CREB	15,19	CBP	CREB	1387	1385	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Phosphorylated CREB binds specifically to the nuclear protein CBP .
9413984	0	CBP	40,43	CREB	83,87	CBP	CREB	1387	1385	Gene	Gene	domain|nmod|START_ENTITY structure|nmod|domain structure|amod|bound bound|nmod|domain domain|nmod|END_ENTITY	Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB : a model for activator : coactivator interactions .
10760264	0	CBP	51,54	CREB-binding_protein	29,49	CBP	CREB-binding protein	12914(Tax:10090)	12914(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A stimulus-specific role for CREB-binding_protein -LRB- CBP -RRB- in T cell receptor-activated tumor_necrosis_factor_alpha gene expression .
15950780	0	CBP	48,51	CREB-binding_protein	26,46	CBP	CREB-binding protein	54244(Tax:10116)	54244(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Interleukin-1beta induces CREB-binding_protein -LRB- CBP -RRB- mRNA in brain and the sequencing of rat CBP .
24338025	0	CBP	76,79	CREB-binding_protein	54,74	CBP	CREB-binding protein	1387	1387	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	NF-kB and enhancer-binding CREB protein scaffolded by CREB-binding_protein -LRB- CBP -RRB- / p300 proteins regulate CD59 protein expression to protect cells from complement attack .
14974086	0	CBP	12,15	CREBBP	17,23	CBP	CREBBP	1387	1387	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of CBP -LRB- CREBBP -RRB- gene deletions in Rubinstein-Taybi_syndrome patients using real-time quantitative PCR .
16969114	0	CBP	48,51	CREB_binding_protein	26,46	CBP	CREB binding protein	1387	1387	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of CREB_binding_protein -LRB- CBP -RRB- with nuclear transport proteins and modulation by HDAC inhibitors .
22508984	0	CBP	22,25	CREB_binding_protein	0,20	CBP	CREB binding protein	12914(Tax:10090)	12914(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	CREB_binding_protein -LRB- CBP -RRB- activation is required for luteinizing_hormone_beta expression and normal fertility in mice .
12954226	0	CBP	56,59	DNA_binding_protein	11,30	CBP	DNA binding protein	1387	284390	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Adenovirus DNA_binding_protein inhibits SrCap-activated CBP and CREB-mediated transcription .
16154084	0	CBP	43,46	IRF-3	21,26	CBP	IRF-3	1387	3661	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of IRF-3 in complex with CBP .
12437352	0	CBP	64,67	Jun	71,74	CBP	Jun	1387	3725	Gene	Gene	modes|nmod|START_ENTITY modes|nmod|END_ENTITY	Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB .
20110770	0	CBP	86,89	KAT3	71,75	CBP	KAT3	1387	56267	Gene	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases .
25797267	0	CBP	21,24	Ku80	0,4	CBP	Ku80	1387	7520	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Ku80 cooperates with CBP to promote COX-2 expression and tumor growth .
8654374	0	CBP	32,35	Myb	41,44	CBP	Myb	1387	4602	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Interaction of the co-activator CBP with Myb proteins : effects on Myb-specific transactivation and on the cooperativity with NF-M .
17434128	0	CBP	19,22	NF-kappaB	111,120	CBP	NF-kappaB	1387	4790	Gene	Gene	Phosphorylation|nmod|START_ENTITY promotes|nsubj|Phosphorylation promotes|advcl|switching switching|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
17434128	0	CBP	95,98	NF-kappaB	111,120	CBP	NF-kappaB	1387	4790	Gene	Gene	preference|nmod|START_ENTITY switching|dobj|preference switching|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
26802126	0	CBP	41,44	Polycomb	0,8	CBP	Polycomb	1387	40358(Tax:7227)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain .
12496368	0	CBP	73,76	Sam68	103,108	CBP	Sam68	1387	10657	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68 .
10769018	0	CBP	32,35	beta-catenin	51,63	CBP	beta-catenin	373795(Tax:8355)	399274(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression .
11973335	0	CBP	53,56	beta-catenin	15,27	CBP	beta-catenin	1387	1499	Gene	Gene	CREB-binding_protein|appos|START_ENTITY Acetylation|nmod|CREB-binding_protein Acetylation|nmod|END_ENTITY	Acetylation of beta-catenin by CREB-binding_protein -LRB- CBP -RRB- .
8545107	0	CBP	33,36	c-Jun	15,20	CBP	c-Jun	1387	3725	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Stimulation of c-Jun activity by CBP : c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro .
10644988	0	CBP	76,79	c-Myb	26,31	CBP	c-Myb	1387	4602	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP .
10815807	0	CBP	89,92	c-Myb	36,41	CBP	c-Myb	1387	4602	Gene	Gene	interaction|nmod|START_ENTITY promoter|nmod|interaction promoter|amod|END_ENTITY	HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300 .
11073948	0	CBP	54,57	c-Myb	22,27	CBP	c-Myb	1387	4602	Gene	Gene	CREB-binding_protein|appos|START_ENTITY END_ENTITY|nmod|CREB-binding_protein	Increased affinity of c-Myb for CREB-binding_protein -LRB- CBP -RRB- after CBP-induced acetylation .
15019774	0	CBP	40,43	c-Myb	83,88	CBP	c-Myb	1387	4602	Gene	Gene	domain|nmod|START_ENTITY structure|nmod|domain bound|nsubj|structure bound|nmod|domain domain|nmod|END_ENTITY	Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb .
27082784	0	CBP	56,59	c-Myb	102,107	CBP	c-Myb	12914(Tax:10090)	17863(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY affects|nsubj|mutation affects|dobj|stability stability|nmod|CBP CBP|amod|complex complex|amod|END_ENTITY	Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP : c-Myb complex .
27082784	0	CBP	98,101	c-Myb	102,107	CBP	c-Myb	12914(Tax:10090)	17863(Tax:10090)	Gene	Gene	START_ENTITY|amod|complex complex|amod|END_ENTITY	Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP : c-Myb complex .
9357978	0	CBP	74,77	c-myb	48,53	CBP	c-myb	1387	4602	Gene	Gene	START_ENTITY|nsubj|Mapping Mapping|nmod|interactions interactions|nmod|END_ENTITY	Mapping of protein-protein interactions between c-myb and its coactivator CBP by a new phage display technique .
9109493	0	CBP	11,14	cubitus_interruptus	36,55	CBP	cubitus interruptus	31669(Tax:7227)	43767(Tax:7227)	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	Drosophila CBP is a co-activator of cubitus_interruptus in hedgehog signalling .
9192892	0	CBP	45,48	p/CIP	33,38	CBP	p/CIP	1387	8202;102157402	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function .
14759370	0	CBP	59,62	p53	66,69	CBP	p53	1387	7157	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation .
15156194	0	CBP	19,22	p53	98,101	CBP	p53	1387	7157	Gene	Gene	Utilization|nmod|START_ENTITY Utilization|nmod|inhibition inhibition|compound|END_ENTITY	Utilization of the CBP but not the p300 co-activator by human_T-lymphotropic_virus_type-2 Tax for p53 inhibition .
15254196	0	CBP	63,66	p53	0,3	CBP	p53	1387	7157	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	p53 targets simian_virus_40 large T antigen for acetylation by CBP .
17434128	0	CBP	19,22	p53	104,107	CBP	p53	1387	7157	Gene	Gene	Phosphorylation|nmod|START_ENTITY promotes|nsubj|Phosphorylation promotes|advcl|switching switching|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
17434128	0	CBP	95,98	p53	104,107	CBP	p53	1387	7157	Gene	Gene	preference|nmod|START_ENTITY switching|dobj|preference switching|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
19220000	0	CBP	82,85	p53	32,35	CBP	p53	1387	7157	Gene	Gene	domain|nmod|START_ENTITY Mapping|nmod|domain Mapping|dobj|interactions interactions|nmod|domain domain|compound|END_ENTITY	Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP .
19805293	0	CBP	0,3	p53	58,61	CBP	p53	1387	7157	Gene	Gene	ligases|nsubj|START_ENTITY ligases|nmod|END_ENTITY	CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53 .
20962272	0	CBP	59,62	p53	22,25	CBP	p53	1387	7157	Gene	Gene	CREB-binding_protein|appos|START_ENTITY binding|nmod|CREB-binding_protein binding|nsubj|enhancement enhancement|nmod|END_ENTITY	Graded enhancement of p53 binding to CREB-binding_protein -LRB- CBP -RRB- by multisite phosphorylation .
21220944	0	CBP	30,33	p53	63,66	CBP	p53	12914(Tax:10090)	22060(Tax:10090)	Gene	Gene	dispensable|nsubjpass|START_ENTITY dispensable|nmod|targets targets|nummod|END_ENTITY	Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways .
21271695	0	CBP	80,83	p53	100,103	CBP	p53	1387	7157	Gene	Gene	modulators|nmod|START_ENTITY design|nmod|modulators design|dep|class class|nmod|inhibitors inhibitors|compound|END_ENTITY	Rational design of cyclic peptide modulators of the transcriptional coactivator CBP : a new class of p53 inhibitors .
22198284	0	CBP	66,69	p53	0,3	CBP	p53	1387	7157	Gene	Gene	induce|nmod|START_ENTITY induce|nsubj|mutants mutants|compound|END_ENTITY	p53 mutants induce transcription of NF-kB2 in H1299 cells through CBP and STAT binding on the NF-kB2 promoter and gain of function activity .
22280219	0	CBP	162,165	p53	107,110	CBP	p53	1387	7157	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|subdomains subdomains|compound|END_ENTITY	Quantitative analysis of multisite protein-ligand interactions by NMR : binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP .
9830059	0	CBP	60,63	p53	19,22	CBP	p53	1387	7157	Gene	Gene	interaction|nmod|START_ENTITY increases|acl|interaction serine|dobj|increases serine|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of p53 serine 15 increases interaction with CBP .
11097423	0	CBP	46,49	tax	80,83	CBP	tax	1387	6900	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Insight into the tumor suppressor function of CBP through the viral oncoprotein tax .
9399571	0	CBP/p300	0,8	Ah_receptor_nuclear_translocator	64,96	CBP/p300	Ah receptor nuclear translocator	1387;2033	405	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	CBP/p300 functions as a possible transcriptional coactivator of Ah_receptor_nuclear_translocator -LRB- Arnt -RRB- .
18819102	0	CBP/p300	50,58	Interleukin-4	0,13	CBP/p300	Interleukin-4	1387;2033	3565	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-4 activates androgen_receptor through CBP/p300 .
10215616	0	CBP/p300	229,237	Msx1	34,38	CBP/p300	Msx1	12914;328572	17701(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY interactions|nmod|protein mediated|nmod|interactions mediated|nsubjpass|autorepression autorepression|nmod|gene gene|amod|END_ENTITY	Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding_protein , Sp1 and cAMP-response-element-binding_protein-binding_protein -LRB- CBP/p300 -RRB- .
10215616	0	CBP/p300	229,237	Msx1	75,79	CBP/p300	Msx1	12914;328572	17701(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding_protein , Sp1 and cAMP-response-element-binding_protein-binding_protein -LRB- CBP/p300 -RRB- .
11601899	0	CBP/p300	57,65	RBP-Jk	95,101	CBP/p300	RBP-Jk	1387;2033	3516	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Intranuclear localization of the transcription coadaptor CBP/p300 and the transcription factor RBP-Jk in relation to EBNA-2 and -5 in B lymphocytes .
15641773	0	CBP/p300	0,8	TAZ1	9,13	CBP/p300	TAZ1	1387;2033	10472	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding .
11349124	0	CBP/p300	52,60	TReP-132	28,36	CBP/p300	TReP-132	1387;2033	55809	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression .
12724399	0	CBP/p300	19,27	Tax	0,3	CBP/p300	Tax	1387;2033	6900	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	Tax recruitment of CBP/p300 , via the KIX domain , reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent .
18819102	0	CBP/p300	50,58	androgen_receptor	24,41	CBP/p300	androgen receptor	1387;2033	367	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	Interleukin-4 activates androgen_receptor through CBP/p300 .
24607903	0	CBP/p300	104,112	erythropoietin	13,27	CBP/p300	erythropoietin	1387;2033	2056	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300 .
15271374	0	CBP/p300	89,97	interleukin-5	6,19	CBP/p300	interleukin-5	1387;2033	3567	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP , NF-AT and AP-1 .
11823864	0	CBP/p300	45,53	p160	57,61	CBP/p300	p160	1387;2033	10514	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators .
11713256	0	CBP/p300	8,16	thyroid_transcription_factor-1	110,140	CBP/p300	thyroid transcription factor-1	1387;2033	7080	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary_surfactant_protein-A -LRB- SP-A -RRB- gene by thyroid_transcription_factor-1 -LRB- TTF-1 -RRB- .
7656593	0	CBP2	81,85	colligin-2	64,74	CBP2	colligin-2	871	871	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation , characterization and chromosomal assignment of human colligin-2 gene -LRB- CBP2 -RRB- .
10023073	0	CBP2	53,57	hsp47	41,46	CBP2	hsp47	871	871	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human genome has only one functional hsp47 gene -LRB- CBP2 -RRB- and a pseudogene -LRB- pshsp47 -RRB- .
15374100	0	CBP35	39,44	prion_protein	15,28	CBP35	prion protein	83781(Tax:10116)	24686(Tax:10116)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Interaction of prion_protein mRNA with CBP35 and other cellular proteins : possible implications for prion replication and age-dependent changes .
20691628	0	CBP80	47,52	UPF1	0,4	CBP80	UPF1	4686	5976	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	UPF1 association with the cap-binding_protein , CBP80 , promotes nonsense-mediated mRNA decay at two distinct steps .
18449627	0	CBR1	54,58	carbonyl_reductase_1	32,52	CBR1	carbonyl reductase 1	873	873	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of polymorphic human carbonyl_reductase_1 -LRB- CBR1 -RRB- by the cardioprotectant flavonoid 7-monohydroxyethyl_rutoside -LRB- monoHER -RRB- .
22531821	0	CBR1	35,39	carbonyl_reductase_1	13,33	CBR1	carbonyl reductase 1	873	873	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of carbonyl_reductase_1 -LRB- CBR1 -RRB- expression in human lung tissues and lung_cancer cells by the cigarette smoke constituent benzo -LSB- a -RSB- pyrene .
23133646	0	CBR1	56,60	carbonyl_reductase_1	34,54	CBR1	carbonyl reductase 1	873	873	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	MicroRNAs differentially regulate carbonyl_reductase_1 -LRB- CBR1 -RRB- gene expression dependent on the allele status of the common polymorphic variant rs9024 .
23247010	0	CBR1	42,46	carbonyl_reductase_1	20,40	CBR1	carbonyl reductase 1	873	873	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human carbonyl_reductase_1 -LRB- CBR1 , SDR21C1 -RRB- gene by transcription factor Nrf2 .
20806931	0	CBR3	42,46	carbonyl_reductase_3	20,40	CBR3	carbonyl reductase 3	874	874	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human carbonyl_reductase_3 -LRB- CBR3 ; SDR21C2 -RRB- expression by Nrf2 in cultured cancer cells .
22425771	0	CBR3	42,46	carbonyl_reductase_3	20,40	CBR3	carbonyl reductase 3	874	874	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human carbonyl_reductase_3 -LRB- CBR3 ; SDR21C2 -RRB- is inducible by pro-inflammatory stimuli .
21273695	0	CBS	80,83	cystathionine_b-synthase	54,78	CBS	cystathionine b-synthase	875	875	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel alleles of 31-bp VNTR polymorphism in the human cystathionine_b-synthase -LRB- CBS -RRB- gene were detected in healthy Asians .
26803480	0	CBS	66,69	cystathionine_b-synthase	40,64	CBS	cystathionine b-synthase	101703797	101703797	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Low sulfide levels and a high degree of cystathionine_b-synthase -LRB- CBS -RRB- activation by S-adenosylmethionine -LRB- SAM -RRB- in the long-lived naked_mole-rat .
11528503	0	CBS	49,52	cystathionine_beta-synthase	20,47	CBS	cystathionine beta-synthase	875	875	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A 31 bp VNTR in the cystathionine_beta-synthase -LRB- CBS -RRB- gene is associated with reduced CBS activity and elevated post-load homocysteine levels .
8094069	0	CBS	52,55	cystathionine_beta-synthase	23,50	CBS	cystathionine beta-synthase	875	875	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Linkage mapping of the cystathionine_beta-synthase -LRB- CBS -RRB- gene on human chromosome 21 using a DNA polymorphism in the 3 ' untranslated region .
9708897	0	CBS	66,69	cystathionine_beta-synthase	37,64	CBS	cystathionine beta-synthase	875	875	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of a novel deletion in the cystathionine_beta-synthase -LRB- CBS -RRB- gene using an improved genomic DNA based method .
9790750	0	CBS	39,42	cystathionine_beta-synthase	10,37	CBS	cystathionine beta-synthase	875	875	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human cystathionine_beta-synthase -LRB- CBS -RRB- gene : complete sequence , alternative splicing , and polymorphisms .
12588964	0	CBS	47,50	cystathionine_beta_synthase	18,45	CBS	cystathionine beta synthase	12411(Tax:10090)	12411(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the cystathionine_beta_synthase -LRB- CBS -RRB- gene during mouse development and immunolocalization in adult brain .
2550765	0	CBS1	43,47	cytochrome_b	78,90	CBS1	cytochrome b	851491(Tax:4932)	854583(Tax:4932)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|activator activator|nmod|END_ENTITY	Chromosomal localization and expression of CBS1 , a translational activator of cytochrome_b in yeast .
23474493	0	CBX8	0,4	SIRT1	104,109	CBX8	SIRT1	57332	23411	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	CBX8 suppresses Sirtinol-induced premature senescence in human breast_cancer cells via cooperation with SIRT1 .
25838250	0	CBY	14,17	CBY	37,40	CBY	CBY	25776	25776	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CBY and methylation of CBY at promoter region in human laryngeal_squamous_cell_carcinoma .
25838250	0	CBY	37,40	CBY	14,17	CBY	CBY	25776	25776	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CBY and methylation of CBY at promoter region in human laryngeal_squamous_cell_carcinoma .
1913973	0	CC-1065	53,60	CC-1065	76,83	CC-1065	CC-1065	940519(Tax:190650)	940519(Tax:190650)	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	DNA sequence recognition by the antitumor antibiotic CC-1065 and analogs of CC-1065 .
1913973	0	CC-1065	76,83	CC-1065	53,60	CC-1065	CC-1065	940519(Tax:190650)	940519(Tax:190650)	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	DNA sequence recognition by the antitumor antibiotic CC-1065 and analogs of CC-1065 .
25620478	0	CC-chemokine_ligand_18	15,37	CCL18	39,44	CC-chemokine ligand 18	CCL18	6362	6362	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dep|Expression	-LSB- Expression of CC-chemokine_ligand_18 -LRB- CCL18 -RRB- in the serum and pleural_effusion of non-small-cell_lung_cancer patients and its regulatory effect on the differentiation of monocyte-derived dendritic cells . -RSB-
19958819	0	CC-chemokine_ligand_18	0,22	pulmonary_activation-regulated_chemokine	23,63	CC-chemokine ligand 18	pulmonary activation-regulated chemokine	6362	6362	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	CC-chemokine_ligand_18 / pulmonary_activation-regulated_chemokine expression in the CNS with special reference to traumatic_brain_injuries and neoplastic_disorders .
23409871	0	CC-chemokine_receptor_4	90,113	CCR4	115,119	CC-chemokine receptor 4	CCR4	1233	1233	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and structure-activity relationships of indazole_arylsulfonamides as allosteric CC-chemokine_receptor_4 -LRB- CCR4 -RRB- antagonists .
24515101	0	CC-chemokine_receptor_4	110,133	CCR4	135,139	CC-chemokine receptor 4	CCR4	1233	1233	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Lead identification and structure-activity relationships of heteroarylpyrazole_arylsulfonamides as allosteric CC-chemokine_receptor_4 -LRB- CCR4 -RRB- antagonists .
24909677	0	CC-chemokine_receptor_4	82,105	CCR4	107,111	CC-chemokine receptor 4	CCR4	1233	1233	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Lead identification of benzimidazolone and azabenzimidazolone_arylsulfonamides as CC-chemokine_receptor_4 -LRB- CCR4 -RRB- antagonists .
26983670	0	CC-chemokine_receptor_5	11,34	ROCK2	38,43	CC-chemokine receptor 5	ROCK2	117029(Tax:10116)	25537(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of CC-chemokine_receptor_5 on ROCK2 and P-MLC2 expression after focal cerebral_ischaemia-reperfusion injury in rats .
19205286	0	CC10	26,30	Clara_cell_10	11,24	CC10	Clara cell 10	7356	7356	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Effects of Clara_cell_10 -LRB- CC10 -RRB- protein on symptoms and signs of allergic_rhinitis .
17716718	0	CC10	62,66	Clara_cell_protein_10	39,60	CC10	Clara cell protein 10	7356	7356	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Infant frequent wheezing correlated to Clara_cell_protein_10 -LRB- CC10 -RRB- polymorphism and concentration , but not allergy sensitization , in a perinatal cohort study .
16150617	0	CC10	44,48	Shh	78,81	CC10	Shh	22287(Tax:10090)	20423(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	FITC-induced murine pulmonary_inflammation : CC10 up-regulation and concurrent Shh expression .
10579545	0	CC16	81,85	Clara_Cell_Protein	61,79	CC16	Clara Cell Protein	7356	7356	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Effects of pregnancy and delivery on serum concentrations of Clara_Cell_Protein -LRB- CC16 -RRB- , an endogenous anticytokine : lower serum CC16 is related to postpartum depression There is now some evidence that lower serum concentrations of Clara_Cell_Protein -LRB- CC16 -RRB- are related to stress-induced anxiety , psychoses and major_depression .
26239602	0	CC16	34,38	Clara_cell_16-kDa_protein	7,32	CC16	Clara cell 16-kDa protein	7356	7356	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Serum Clara_cell_16-kDa_protein -LRB- CC16 -RRB- levels and lung_impairment in systemic_sclerosis patients -RSB- .
16251377	0	CC16	99,103	Clara_cell_protein	79,97	CC16	Clara cell protein	7356	7356	Gene	Gene	changes|appos|START_ENTITY changes|compound|END_ENTITY	Glutaraldehyde-induced occupational_asthma : BALF components and BALF and serum Clara_cell_protein -LRB- CC16 -RRB- changes due to specific inhalatory provocation test .
9072037	0	CC16	48,52	Clara_cell_protein	28,46	CC16	Clara cell protein	7356	7356	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Transient increase of serum Clara_cell_protein -LRB- CC16 -RRB- after exposure to smoke .
17338426	0	CC16	54,58	cell_secretory_protein	30,52	CC16	cell secretory protein	7356	7356	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between the clara cell_secretory_protein -LRB- CC16 -RRB- G38A polymorphism and the progression of IgA_nephropathy .
25700379	0	CC16	52,56	cell_secretory_protein-16	25,50	CC16	cell secretory protein-16	22287(Tax:10090)	22287(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Protective role for club cell_secretory_protein-16 -LRB- CC16 -RRB- in the development of chronic_obstructive_pulmonary_disease .
15912112	0	CC16	56,60	clara_cell_secretory_protein	26,54	CC16	clara cell secretory protein	7356	7356	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Decreased serum levels of clara_cell_secretory_protein -LRB- CC16 -RRB- are associated with bronchiolitis_obliterans and may permit early diagnosis in patients after allogeneic stem-cell_transplantation .
22406677	0	CC2D1A	0,6	CHMP4B	35,41	CC2D1A	CHMP4B	54862	128866	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	CC2D1A is a regulator of ESCRT-III CHMP4B .
17535813	0	CC2D1A	35,41	dopamine-D2_receptor	71,91	CC2D1A	dopamine-D2 receptor	54862	1813	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Differential repression by freud-1 / CC2D1A at a polymorphic site in the dopamine-D2_receptor gene .
21155902	0	CC2D1B	8,14	Freud-2	0,7	CC2D1B	Freud-2	319965(Tax:10090)	319965(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Freud-2 / CC2D1B mediates dual repression of the serotonin-1A receptor gene .
26485645	0	CC2D2A	23,29	NINL	46,50	CC2D2A	NINL	57545	22981	Gene	Gene	Associates|compound|START_ENTITY Associates|nmod|END_ENTITY	The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking .
18460819	0	CCA1	63,67	CIRCADIAN_CLOCK-ASSOCIATED_1	69,97	CCA1	CIRCADIAN CLOCK-ASSOCIATED 1	819296(Tax:3702)	819296(Tax:3702)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	The function of the clock-associated transcriptional regulator CCA1 -LRB- CIRCADIAN_CLOCK-ASSOCIATED_1 -RRB- in Arabidopsis_thaliana .
9657153	0	CCA1	61,65	CIRCADIAN_CLOCK_ASSOCIATED_1	31,59	CCA1	CIRCADIAN CLOCK ASSOCIATED 1	819296(Tax:3702)	819296(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Constitutive expression of the CIRCADIAN_CLOCK_ASSOCIATED_1 -LRB- CCA1 -RRB- gene disrupts circadian rhythms and suppresses its own expression .
21884973	0	CCA1	37,41	DET1	27,31	CCA1	DET1	819296(Tax:3702)	826609(Tax:3702)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock .
20945532	0	CCAAT-Displacement-protein	92,118	CUX1	120,124	CCAAT-Displacement-protein	CUX1	1523	1523	Gene	Gene	repressor|amod|START_ENTITY repressor|appos|END_ENTITY	The Promyelocytic_Leukemia Zinc Finger -LRB- PLZF -RRB- gene is a novel transcriptional target of the CCAAT-Displacement-protein -LRB- CUX1 -RRB- repressor .
15908194	0	CCAAT-binding_factor	45,65	Sox9	24,28	CCAAT-binding factor	Sox9	10153	6662	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|amod|END_ENTITY	Regulation of the human Sox9 promoter by the CCAAT-binding_factor .
21344389	0	CCAAT-enhancer-binding_protein_beta	0,35	MMP-1	50,55	CCAAT-enhancer-binding protein beta	MMP-1	1051	4312	Gene	Gene	activation|amod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	CCAAT-enhancer-binding_protein_beta activation of MMP-1 gene expression in SW1353 cells : independent roles of extracellular signal-regulated and p90/ribosomal _ S6_kinases .
11584018	0	CCAAT_displacement_protein	23,49	CDP	51,54	CCAAT displacement protein	CDP	1523	1523	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Phosphorylation of the CCAAT_displacement_protein -LRB- CDP -RRB- / Cux transcription factor by cyclin_A-Cdk1 modulates its DNA binding activity in G -LRB- 2 -RRB- .
1885602	0	CCAAT_displacement_protein	0,26	gp91-phox	73,82	CCAAT displacement protein	gp91-phox	1523	1536	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	CCAAT_displacement_protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter .
19723873	0	CCAAT_enhancer_binding_protein-beta	0,35	matrix_metalloproteinase-1	46,72	CCAAT enhancer binding protein-beta	matrix metalloproteinase-1	1051	4312	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	CCAAT_enhancer_binding_protein-beta regulates matrix_metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung_carcinoma cells .
11597733	0	CCAAT_enhancer_binding_protein_epsilon	47,85	C/EBPepsilon	87,99	CCAAT enhancer binding protein epsilon	C/EBPepsilon	1053	1053	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	DNase I hypersensitivity analysis of the human CCAAT_enhancer_binding_protein_epsilon -LRB- C/EBPepsilon -RRB- gene .
26617872	0	CCAR2	11,16	DBC1	5,9	CCAR2	DBC1	57805	57805	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	High DBC1 -LRB- CCAR2 -RRB- expression in gallbladder_carcinoma is associated with favorable clinicopathological factors .
25661920	0	CCAR2	0,5	LXRa	44,48	CCAR2	LXRa	57805	10062	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	CCAR2 negatively regulates nuclear receptor LXRa by competing with SIRT1 deacetylase .
17971335	0	CCB2	35,39	HCF208	0,6	CCB2	HCF208	5718457(Tax:3055)	835287(Tax:3702)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	HCF208 , a homolog of Chlamydomonas CCB2 , is required for accumulation of native cytochrome_b6 in Arabidopsis_thaliana .
25297545	0	CCCTC-Binding_Factor	12,32	CTCF	34,38	CCCTC-Binding Factor	CTCF	10664	10664	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of CCCTC-Binding_Factor -LRB- CTCF -RRB- in Genomic Imprinting , Development , and Reproduction .
18539602	0	CCCTC-binding_factor	0,20	PARP-1	31,37	CCCTC-binding factor	PARP-1	13018(Tax:10090)	11545(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CCCTC-binding_factor activates PARP-1 affecting DNA methylation machinery .
17583694	0	CCCTC_binding_factor	19,39	CTCF	41,45	CCCTC binding factor	CTCF	10664	10664	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Functional role of CCCTC_binding_factor -LRB- CTCF -RRB- in stress-induced apoptosis .
23843455	0	CCCTC_binding_factor	115,135	CTCF	137,141	CCCTC binding factor	CTCF	10664	10664	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- - induced corneal_epithelial wound healing through nuclear factor kB subtype-regulated CCCTC_binding_factor -LRB- CTCF -RRB- activation .
17122106	0	CCCTC_binding_factor	36,56	Pax6	0,4	CCCTC binding factor	Pax6	13018(Tax:10090)	18508(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Pax6 regulation in retinal cells by CCCTC_binding_factor .
23727834	0	CCDC28B	42,49	SIN1	95,99	CCDC28B	SIN1	79140	79109	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	The Bardet-Biedl_syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex .
23402890	0	CCDC40	104,110	GAA	83,86	CCDC40	GAA	55036	2548	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Identification of the first deletion-insertion involving the complete structure of GAA gene and part of CCDC40 gene mediated by an Alu element .
17643121	0	CCDC98	0,6	BRCA1	15,20	CCDC98	BRCA1	84142	672	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	CCDC98 targets BRCA1 to DNA damage sites .
24858563	0	CCHCR1	0,6	EDC4	22,26	CCHCR1	EDC4	54535	23644	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CCHCR1 interacts with EDC4 , suggesting its localization in P-bodies .
17221218	0	CCHCR1	4,10	HCR	12,15	CCHCR1	HCR	54535	54535	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The CCHCR1 -LRB- HCR -RRB- gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes .
2999733	0	CCK	13,16	ACTH	33,37	CCK	ACTH	609547(Tax:9615)	403659(Tax:9615)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of CCK and bombesin on ACTH and cortisol secretion in the conscious dog .
22648622	0	CCK	58,61	Calcium-sensing_receptor	0,24	CCK	Calcium-sensing receptor	885	846	Gene	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Calcium-sensing_receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells .
11509018	0	CCK	17,20	Cholecystokinin	0,15	CCK	Cholecystokinin	885	885	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- gene as a possible risk factor for smoking : a replication in two independent samples .
2437570	0	CCK	16,19	GIP	0,3	CCK	GIP	25298(Tax:10116)	25040(Tax:10116)	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	GIP potentiates CCK stimulated pancreatic enzyme secretion : correlation of anatomical structures with the effects of GIP and CCK on amylase secretion .
19940064	0	CCK	0,3	Galpha13	51,59	CCK	Galpha13	12424(Tax:10090)	14674(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini .
7977749	0	CCK	81,84	Nucleoside_diphosphate_kinase	0,29	CCK	Nucleoside diphosphate kinase	25298(Tax:10116)	298410(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY regulates|dobj|receptor regulates|nsubj|END_ENTITY	Nucleoside_diphosphate_kinase associated with rat pancreatic membranes regulates CCK receptor affinity .
10960361	0	CCK	11,14	PACAP	37,42	CCK	PACAP	885	116	Gene	Gene	gene|compound|START_ENTITY Control|nmod|gene transcription|nsubj|Control transcription|nmod|END_ENTITY	Control of CCK gene transcription by PACAP in STC-1 cells .
10960361	0	CCK	11,14	STC-1	46,51	CCK	STC-1	885	6781	Gene	Gene	gene|compound|START_ENTITY Control|nmod|gene transcription|nsubj|Control transcription|nmod|PACAP PACAP|nmod|cells cells|compound|END_ENTITY	Control of CCK gene transcription by PACAP in STC-1 cells .
12943684	0	CCK	65,68	STC-1	4,9	CCK	STC-1	885	6781	Gene	Gene	release|compound|START_ENTITY express|advcl|release express|nsubj|cells cells|compound|END_ENTITY	The STC-1 cells express functional orexin-A receptors coupled to CCK release .
17290006	0	CCK	48,51	STC-1	83,88	CCK	STC-1	885	6781	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|cells cells|compound|END_ENTITY	GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells .
21998136	0	CCK	44,47	STC-1	94,99	CCK	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY critical|nmod|secretion critical|nmod|line line|appos|END_ENTITY	TRPM5 is critical for linoleic_acid-induced CCK secretion from the enteroendocrine cell line , STC-1 .
22648622	0	CCK	58,61	STC-1	91,96	CCK	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Calcium-sensing_receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells .
24357536	0	CCK	29,32	STC-1	56,61	CCK	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY induce|dobj|secretion induce|nmod|cells cells|compound|END_ENTITY	Unsaturated aldehydes induce CCK secretion via TRPA1 in STC-1 cells .
24759185	0	CCK	47,50	STC-1	86,91	CCK	STC-1	885	6781	Gene	Gene	release|nmod|START_ENTITY ligands|nmod|release taste|dobj|ligands taste|xcomp|END_ENTITY	Effect of five taste ligands on the release of CCK from an enteroendocrine cell line , STC-1 .
9756498	0	CCK	41,44	STC-1	58,63	CCK	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Inhibition of Na + / H + exchange stimulates CCK secretion in STC-1 cells .
24357536	0	CCK	29,32	TRPA1	47,52	CCK	TRPA1	885	8989	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Unsaturated aldehydes induce CCK secretion via TRPA1 in STC-1 cells .
24619096	0	CCK	31,34	TrkB	12,16	CCK	TrkB	885	4915	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity .
16169531	0	CCK	111,114	c-Fos	123,128	CCK	c-Fos	25298(Tax:10116)	314322(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Strain differences in myenteric neuron number and CCK1 receptor mRNA expression may account for differences in CCK induced c-Fos activation .
1415544	0	CCK	0,3	c-fos	39,44	CCK	c-fos	25298(Tax:10116)	314322(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	CCK , bombesin , and carbachol stimulate c-fos , c-jun , and c-myc oncogene expression in rat pancreatic acini .
1557514	0	CCK	41,44	cholecystokinin	24,39	CCK	cholecystokinin	885	885	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of plasma cholecystokinin -LRB- CCK -RRB- concentrations by bioassay and radioimmunoassay in man .
18462884	0	CCK	40,43	cholecystokinin	23,38	CCK	cholecystokinin	12424(Tax:10090)	12424(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Prenatal expression of cholecystokinin -LRB- CCK -RRB- in the central nervous system -LRB- CNS -RRB- of mouse .
22849841	0	CCK	47,50	cholecystokinin	30,45	CCK	cholecystokinin	25298(Tax:10116)	25298(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Anorexic effect of peripheral cholecystokinin -LRB- CCK -RRB- varies with age and body composition -LRB- short communication -RRB- .
3773639	0	CCK	72,75	cholecystokinin	55,70	CCK	cholecystokinin	12424(Tax:10090)	12424(Tax:10090)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	A new simple mouse model for the in vivo evaluation of cholecystokinin -LRB- CCK -RRB- antagonists : comparative potencies and durations of action of nonpeptide antagonists .
6522644	0	CCK	66,69	cholecystokinin	49,64	CCK	cholecystokinin	885	885	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and heterogeneity of immunoreactive cholecystokinin -LRB- CCK -RRB- in the mucosa of the porcine gastrointestinal tract .
8432795	0	CCK	134,137	cholecystokinin	21,36	CCK	cholecystokinin	885	885	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role END_ENTITY|dep|evidence	Reduced postprandial cholecystokinin -LRB- CCK -RRB- secretion in patients with noninsulin-dependent_diabetes_mellitus : evidence for a role for CCK in regulating postprandial hyperglycemia .
8552311	0	CCK	37,40	cholecystokinin	20,35	CCK	cholecystokinin	25298(Tax:10116)	25298(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Impaired release of cholecystokinin -LRB- CCK -RRB- from synaptosomes in old rats .
15550621	0	CCK	0,3	ghrelin	49,56	CCK	ghrelin	25298(Tax:10116)	59301(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	CCK inhibits the orexigenic effect of peripheral ghrelin .
10666030	0	CCK	0,3	mob-1	15,20	CCK	mob-1	25298(Tax:10116)	353229(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	CCK stimulates mob-1 expression and NF-kappaB activation via protein kinase C and intracellular Ca -LRB- 2 + -RRB- .
9252447	0	CCK	23,26	p70s6k	0,6	CCK	p70s6k	25298(Tax:10116)	83840(Tax:10116)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	p70s6k is activated by CCK in rat pancreatic acini .
7308593	0	CCK	51,54	pancreatic_polypeptide	15,37	CCK	pancreatic polypeptide	885	5539	Gene	Gene	START_ENTITY|nsubj|release release|nmod|END_ENTITY	The release of pancreatic_polypeptide by exogenous CCK in man and dog .
9575857	0	CCK	58,61	somatostatin	32,44	CCK	somatostatin	101116683	443006(Tax:9940)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of fundic and antral somatostatin secretion by CCK and gastrin .
16509592	0	CCK-1	110,115	CCK-2_receptor	116,130	CCK-1	CCK-2 receptor	56477	887	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1 / CCK-2_receptor antagonists .
16509592	0	CCK-2_receptor	116,130	CCK-1	110,115	CCK-2 receptor	CCK-1	887	56477	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1 / CCK-2_receptor antagonists .
1862688	0	CCK-4	46,51	insulin	25,32	CCK-4	insulin	5754	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Selective stimulation of insulin secretion by CCK-4 analogues having N-terminal modifications .
2694715	0	CCK-4	44,49	insulin	53,60	CCK-4	insulin	5754	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of some novel synthetic analogues of CCK-4 on insulin and glucagon secretion .
6130663	0	CCK-8	73,78	GIP	47,50	CCK-8	GIP	12424(Tax:10090)	14607(Tax:10090)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Interaction of gastric inhibitory polypeptide -LRB- GIP -RRB- and cholecystokinin -LRB- CCK-8 -RRB- with basal and stimulated insulin secretion in mice .
25771084	0	CCK-8	35,40	NPY	43,46	CCK-8	NPY	885	4852	Gene	Gene	-|dep|START_ENTITY -|compound|END_ENTITY	Relative distribution of gastrin - , CCK-8 - , NPY - and CGRP-immunoreactive cells in the digestive tract of dorado -LRB- Salminus brasiliensis -RRB- .
8060296	0	CCK-A	80,85	Gastrin	0,7	CCK-A	Gastrin	886	2520	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Gastrin stimulates growth of human colon_cancer cells via a receptor other than CCK-A or CCK-B .
15682471	0	CCK-A	12,17	gastrin	45,52	CCK-A	gastrin	886	2520	Gene	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of CCK-A , B receptors and effect of gastrin and cholecystokinin on growth of pancreatobiliary_cancer cell lines .
16105969	0	CCK1	36,40	cholecystokinin	41,56	CCK1	cholecystokinin	56477	885	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Immunohistochemical localization of CCK1 cholecystokinin receptors in normal and neoplastic human tissues .
16258365	0	CCK1R	80,85	cholecystokinin_1_receptor	52,78	CCK1R	cholecystokinin 1 receptor	886	886	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Advanced qRT-PCR technology allows detection of the cholecystokinin_1_receptor -LRB- CCK1R -RRB- expression in human pancreas .
26043355	0	CCK2R	126,131	Cholecystokinin_2_Receptor	98,124	CCK2R	Cholecystokinin 2 Receptor	12426(Tax:10090)	12426(Tax:10090)	Gene	Gene	Ligand|appos|START_ENTITY Ligand|compound|END_ENTITY	Selective Tumor Targeting of Desacetyl_Vinblastine_Hydrazide and Tubulysin B via Conjugation to a Cholecystokinin_2_Receptor -LRB- CCK2R -RRB- Ligand .
22786615	0	CCK2R	46,51	cholecystokinin_2_receptor	18,44	CCK2R	cholecystokinin 2 receptor	887	887	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Promoting role of cholecystokinin_2_receptor -LRB- CCK2R -RRB- in gastrointestinal_stromal_tumour pathogenesis .
12612900	0	CCK2_receptor	80,93	Gastrin	0,7	CCK2 receptor	Gastrin	887	2520	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Gastrin induces proliferation in Barrett 's _ metaplasia through activation of the CCK2_receptor .
20932834	0	CCK2_receptor	77,90	Gastrin	0,7	CCK2 receptor	Gastrin	887	2520	Gene	Gene	cells|nmod|START_ENTITY increases|nmod|cells increases|nsubj|END_ENTITY	Gastrin increases its own synthesis in gastrointestinal_cancer cells via the CCK2_receptor .
16909104	0	CCK2_receptor	22,35	HIF-1_alpha	75,86	CCK2 receptor	HIF-1 alpha	887	3091	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Constitutively active CCK2_receptor splice variant increases Src-dependent HIF-1_alpha expression and tumor growth .
23341962	0	CCKAR	28,33	Cholecystokinin_A_receptor	0,26	CCKAR	Cholecystokinin A receptor	886	886	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Cholecystokinin_A_receptor -LRB- CCKAR -RRB- gene variation is associated with language lateralization .
9332364	0	CCKAR	43,48	cholecystokinin_type-A_receptor	10,41	CCKAR	cholecystokinin type-A receptor	24889(Tax:10116)	24889(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disrupted cholecystokinin_type-A_receptor -LRB- CCKAR -RRB- gene in OLETF rats .
23975374	0	CCKBR	78,83	MiR-148a	0,8	CCKBR	MiR-148a	887	406940	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-148a regulates the growth and apoptosis in pancreatic_cancer by targeting CCKBR and Bcl-2 .
22885328	0	CCKLR-17D1	24,34	Drosulfakinin	0,13	CCKLR-17D1	Drosulfakinin	32860(Tax:7227)	45845(Tax:7227)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Drosulfakinin activates CCKLR-17D1 and promotes larval locomotion and escape response in Drosophila .
18380907	0	CCL-11	27,33	eotaxin-1	34,43	CCL-11	eotaxin-1	6356	6356	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Differential regulation of CCL-11 / eotaxin-1 and CXCL-8 / IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells .
22039368	0	CCL1	18,22	TIM-3	84,89	CCL1	TIM-3	6346	84868	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of CCL1 as a Gene Differentially Expressed in CD4 T Cells Expressing TIM-3 .
19302817	0	CCL1	61,65	TNFalpha	0,8	CCL1	TNFalpha	6346	7124	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	TNFalpha - and NF-kappaB-dependent induction of the chemokine CCL1 in human macrophages exposed to the atherogenic lipoprotein -LRB- a -RRB- .
23679817	0	CCL11	157,162	CCL26	150,155	CCL11	CCL26	6356	10344	Gene	Gene	IL-8|appos|START_ENTITY IL-8|compound|END_ENTITY	Inhibition by new glucocorticoid antedrugs -LSB- 16a , 17a-d -RSB- isoxazoline and -LSB- 16a , _ 17a-d -RSB- -3 ' - hydroxy-iminoformyl_isoxazoline derivatives of chemotaxis and CCL26 , CCL11 , IL-8 , and RANTES secretion .
20169197	0	CCL11	13,18	IL-9	0,4	CCL11	IL-9	6356	3578	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-9 induces CCL11 expression via STAT3 signalling in human airway_smooth_muscle cells .
20030665	0	CCL11	58,63	Interleukin-13	0,14	CCL11	Interleukin-13	20292(Tax:10090)	16163(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils .
19265112	0	CCL11	43,48	STAT3	18,23	CCL11	STAT3	6356	6774	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Critical role for STAT3 in IL-17A-mediated CCL11 expression in human airway_smooth_muscle cells .
20169197	0	CCL11	13,18	STAT3	34,39	CCL11	STAT3	6356	6774	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	IL-9 induces CCL11 expression via STAT3 signalling in human airway_smooth_muscle cells .
17824960	0	CCL13	53,58	monocyte_chemoattractant_protein-4	10,44	CCL13	monocyte chemoattractant protein-4	6357	6357	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role of monocyte_chemoattractant_protein-4 -LRB- MCP-4 -RRB- / CCL13 from chondrocytes in rheumatoid_arthritis .
19669929	0	CCL15	14,19	Leukotactin-1	0,13	CCL15	Leukotactin-1	6359	6359	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Leukotactin-1 / CCL15 induces cell migration and differentiation of human eosinophilic_leukemia EoL-1 cells through PKCdelta activation .
19669929	0	CCL15	14,19	PKCdelta	114,122	CCL15	PKCdelta	6359	5580	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Leukotactin-1 / CCL15 induces cell migration and differentiation of human eosinophilic_leukemia EoL-1 cells through PKCdelta activation .
20126378	0	CCL15	16,21	matrix_metalloproteinase-9	31,57	CCL15	matrix metalloproteinase-9	6359	4318	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|release release|amod|END_ENTITY	Chemokine Lkn-1 / CCL15 enhances matrix_metalloproteinase-9 release from human macrophages and macrophage-derived foam cells .
19144272	0	CCL16	0,5	CD8	19,22	CCL16	CD8	6360	925	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|+ +|compound|END_ENTITY	CCL16 enhances the CD8 + and CD4 + T cell reactivity to human HER-2 elicited by dendritic cells loaded with rat ortholog HER-2 .
14971049	0	CCL17	24,29	CCL22	13,18	CCL17	CCL22	6361	6367	Gene	Gene	Dominance|nmod|START_ENTITY Dominance|nmod|END_ENTITY	Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells .
14971049	0	CCL17	24,29	CCR4	65,69	CCL17	CCR4	6361	1233	Gene	Gene	Dominance|nmod|START_ENTITY Dominance|nmod|END_ENTITY	Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells .
15466387	0	CCL17	22,27	CCR4	8,12	CCL17	CCR4	20295(Tax:10090)	12773(Tax:10090)	Gene	Gene	ligands|appos|START_ENTITY ligands|nummod|END_ENTITY	Role of CCR4 ligands , CCL17 and CCL22 , during Schistosoma_mansoni egg-induced pulmonary_granuloma formation in mice .
15955100	0	CCL17	94,99	CCR4	31,35	CCL17	CCR4	6361	1233	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of the chemokine receptor CCR4 and its ligand thymus - _ and_activation-regulated_chemokine / CCL17 for lymphocyte recruitment in cutaneous_lupus_erythematosus .
18052724	0	CCL17	55,60	CCR4	33,37	CCL17	CCR4	20295(Tax:10090)	12773(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of chemokine receptor CCR4 and its ligands -LRB- CCL17 and CCL22 -RRB- in murine contact_hypersensitivity .
19630858	0	CCL17	87,92	CCR4	12,16	CCL17	CCR4	6361	1233	Gene	Gene	role|nmod|START_ENTITY reveals|dobj|role reveals|nsubj|Blockade Blockade|nmod|END_ENTITY	Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway_inflammation .
22335621	0	CCL17	155,160	CCR4	190,194	CCL17	CCR4	6361	1233	Gene	Gene	efficacy|nmod|START_ENTITY determine|dobj|efficacy determine|nmod|END_ENTITY	Development of operational models of receptor activation including constitutive receptor activity and their use to determine the efficacy of the chemokine CCL17 at the CC chemokine receptor CCR4 .
24339934	0	CCL17	46,51	CCR4	86,90	CCL17	CCR4	6361	1233	Gene	Gene	domains|nmod|START_ENTITY Engagement|nmod|domains required|nsubjpass|Engagement required|advcl|signaling signaling|nmod|END_ENTITY	Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung .
22533972	0	CCL17	78,83	PI16	0,4	CCL17	PI16	6361	221476	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20 .
18191727	0	CCL17	59,64	STAT6	34,39	CCL17	STAT6	6361	6778	Gene	Gene	element|nmod|START_ENTITY element|compound|END_ENTITY	Identification of a distal tandem STAT6 element within the CCL17 locus .
16859899	0	CCL17	49,54	Thymus_and_activation_regulated_chemokine	0,41	CCL17	Thymus and activation regulated chemokine	6361	6361	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	Thymus_and_activation_regulated_chemokine -LRB- TARC -RRB- / CCL17 and skin_diseases .
25620478	0	CCL18	39,44	CC-chemokine_ligand_18	15,37	CCL18	CC-chemokine ligand 18	6362	6362	Gene	Gene	START_ENTITY|dep|Expression Expression|nmod|END_ENTITY	-LSB- Expression of CC-chemokine_ligand_18 -LRB- CCL18 -RRB- in the serum and pleural_effusion of non-small-cell_lung_cancer patients and its regulatory effect on the differentiation of monocyte-derived dendritic cells . -RSB-
15784687	0	CCL18	39,44	CC_chemokine_ligand_18	15,37	CCL18	CC chemokine ligand 18	6362	6362	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CC_chemokine_ligand_18 -LRB- CCL18 -RRB- in normal and pathological processes .
20568229	0	CCL18	34,39	CXCR4	15,20	CCL18	CXCR4	6362	7852	Gene	Gene	responses|nmod|START_ENTITY responses|nummod|END_ENTITY	Attenuation of CXCR4 responses by CCL18 in acute_lymphocytic_leukemia B cells .
18802075	0	CCL19	62,67	CCR7	35,39	CCL19	CCR7	6363	1236	Gene	Gene	ligation|nmod|START_ENTITY ligation|compound|END_ENTITY	Arrestin_3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21 .
19050397	0	CCL19	36,41	CCR7	23,27	CCL19	CCR7	6363	1236	Gene	Gene	ligands|dobj|START_ENTITY ligands|nsubj|levels levels|nmod|END_ENTITY	Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV_infection : correlation with viral load , disease progression and response to highly active antiretroviral therapy .
19171354	0	CCL19	87,92	CCR7	62,66	CCL19	CCR7	6363	1236	Gene	Gene	+|compound|START_ENTITY fibers|nummod|+ invade|dobj|fibers invade|nsubj|macrophages macrophages|compound|END_ENTITY	CCR7 + myeloid dendritic cells together with CCR7 + T cells and CCR7 + macrophages invade CCL19 + nonnecrotic muscle fibers in inclusion_body_myositis .
21092185	0	CCL19	65,70	CCR7	79,83	CCL19	CCR7	6363	1236	Gene	Gene	responses|nummod|START_ENTITY responses|compound|END_ENTITY	Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell_chronic_lymphocytic_leukemia .
21383953	0	CCL19	58,63	CCR7	86,90	CCL19	CCR7	6363	1236	Gene	Gene	migration|nmod|START_ENTITY impairs|dobj|migration impairs|nmod|down-regulation down-regulation|nmod|END_ENTITY	Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis .
22976543	0	CCL19	29,34	CCR7	61,65	CCL19	CCR7	6363	1236	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	The expression of chemokines CCL19 , CCL21 and their receptor CCR7 in oral_squamous_cell_carcinoma and its relevance to cervical lymph node metastasis .
24990231	0	CCL19	39,44	CCR7	74,78	CCL19	CCR7	6363	1236	Gene	Gene	Contribution|nmod|START_ENTITY END_ENTITY|nsubj|Contribution	Contribution of homeostatic chemokines CCL19 and CCL21 and their receptor CCR7 to coronary_artery_disease .
26729814	0	CCL19	92,97	CCR7	63,67	CCL19	CCR7	6363	1236	Gene	Gene	elicited|nmod|START_ENTITY elicited|nsubj|pathways pathways|nmod|END_ENTITY	Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes .
17881634	0	CCL19	13,18	CD4	71,74	CCL19	CD4	6363	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4 + T cells to HIV-1_infection : a novel model of HIV-1 latency .
24588576	0	CCL19	83,88	CD4	38,41	CCL19	CD4	6363	920	Gene	Gene	pretreated|nmod|START_ENTITY pretreated|nsubj|cells cells|amod|Entry Entry|nmod|HIV HIV|nmod|END_ENTITY	Entry of HIV in primary human resting CD4 -LRB- + -RRB- T cells pretreated with the chemokine CCL19 .
12474232	0	CCL19	27,32	DC-Lamp	36,43	CCL19	DC-Lamp	6363	27074	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential expression of CCL19 by DC-Lamp + mature dendritic cells in human lymph node versus chronically inflamed skin .
12626344	0	CCL19	53,58	macrophage_inflammatory_protein-3_beta	14,52	CCL19	macrophage inflammatory protein-3 beta	6363	6363	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of macrophage_inflammatory_protein-3_beta / CCL19 in pulmonary_sarcoidosis .
20019839	0	CCL2	0,4	AMP-activated_protein_kinase	32,60	CCL2	AMP-activated protein kinase	6347	5563	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	CCL2 is a negative regulator of AMP-activated_protein_kinase to sustain mTOR complex-1 activation , survivin expression , and cell survival in human prostate_cancer PC3 cells .
26839895	0	CCL2	0,4	CCL2	89,93	CCL2	CCL2	6347	6347	Gene	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518 A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance .
26839895	0	CCL2	89,93	CCL2	0,4	CCL2	CCL2	6347	6347	Gene	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518 A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance .
21349590	0	CCL2	36,40	CCL3	42,46	CCL2	CCL3	6347	6348	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
23143790	0	CCL2	47,51	CCL3	28,32	CCL2	CCL3	20296(Tax:10090)	20302(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY expression|nmod|mice expression|nummod|END_ENTITY	Hyperocclusion up-regulates CCL3 expression in CCL2 - and CCR2-deficient mice .
26133170	0	CCL2	10,14	CCL3	16,20	CCL2	CCL3	24770(Tax:10116)	25542(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
26133170	0	CCL2	10,14	CCL3	16,20	CCL2	CCL3	24770(Tax:10116)	25542(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
20599874	0	CCL2	95,99	CCL4	144,148	CCL2	CCL4	6347	6351	Gene	Gene	monocyte_chemoattractant_protein-1|appos|START_ENTITY monocyte_chemoattractant_protein-1|appos|END_ENTITY	3-hydroxyanthranilic_acid is independently associated with monocyte_chemoattractant_protein-1 -LRB- CCL2 -RRB- and macrophage_inflammatory_protein-1beta -LRB- CCL4 -RRB- in patients with chronic_kidney_disease .
21349590	0	CCL2	36,40	CCL5	48,52	CCL2	CCL5	6347	6352	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
26133170	0	CCL2	10,14	CCL5	22,26	CCL2	CCL5	24770(Tax:10116)	81780(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
26133170	0	CCL2	10,14	CCL5	22,26	CCL2	CCL5	24770(Tax:10116)	81780(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
15927208	0	CCL2	126,130	CCR2	0,4	CCL2	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	critical|nmod|START_ENTITY critical|nsubj|expression expression|nummod|END_ENTITY	CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2 .
16150057	0	CCL2	75,79	CCR2	27,31	CCL2	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	chemokine|nmod|START_ENTITY chemokine|nsubj|expression expression|nmod|END_ENTITY	Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1 / CCL2 of GABA-induced currents in spinal cord neurones .
16196033	0	CCL2	154,158	CCR2	36,40	CCL2	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|receptor receptor|compound|END_ENTITY	Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain : functional effect of MCP-1 / CCL2 on calcium mobilization in primary cultured neurons .
18419759	0	CCL2	7,11	CCR2	60,64	CCL2	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	pronociceptive|nsubj|START_ENTITY pronociceptive|ccomp|effective effective|nmod|rats rats|compound|END_ENTITY	Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats .
19535619	0	CCL2	154,158	CCR2	110,114	CCL2	CCR2	6347	729230	Gene	Gene	activity|nmod|START_ENTITY neutralizes|dobj|activity neutralizes|nsubj|protein protein|acl|encoding encoding|dobj|residue residue|nmod|END_ENTITY	A novel recombinant fusion protein encoding a 20-amino_acid residue of the third extracellular -LRB- E3 -RRB- domain of CCR2 neutralizes the biological activity of CCL2 .
20670605	0	CCL2	89,93	CCR2	53,57	CCL2	CCR2	6347	729230	Gene	Gene	differ|nmod|START_ENTITY differ|nmod|expression expression|nmod|END_ENTITY	Porcine monocyte subsets differ in the expression of CCR2 and in their responsiveness to CCL2 .
22177985	0	CCL2	24,28	CCR2	99,103	CCL2	CCR2	6347	12772(Tax:10090)	Gene	Gene	analogue|nmod|START_ENTITY mediates|nsubj|analogue mediates|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	A truncated analogue of CCL2 mediates anti-fibrotic effects on murine fibroblasts independently of CCR2 .
22226505	0	CCL2	0,4	CCR2	16,20	CCL2	CCR2	6347	729230	Gene	Gene	binding|compound|START_ENTITY independent|nsubj|binding independent|advmod|END_ENTITY	CCL2 binding is CCR2 independent in primary adult human astrocytes .
22615942	0	CCL2	27,31	CCR2	0,4	CCL2	CCR2	6347	729230	Gene	Gene	scavenger|nmod|START_ENTITY acts|nmod|scavenger acts|nsubj|END_ENTITY	CCR2 acts as scavenger for CCL2 during monocyte chemotaxis .
24583146	0	CCL2	0,4	CCR2	74,78	CCL2	CCR2	6347	729230	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2 .
26355725	0	CCL2	55,59	CCR2	61,65	CCL2	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	FGF2|compound|START_ENTITY FGF2|appos|END_ENTITY	Prophylactic Subacute Administration of Zinc Increases CCL2 , CCR2 , FGF2 , and IGF-1 Expression and Prevents the Long-Term Memory_Loss in a Rat Model of Cerebral_Hypoxia-Ischemia .
26648448	0	CCL2	122,126	CCR2	73,77	CCL2	CCR2	6347	729230	Gene	Gene	promoting|dobj|START_ENTITY cells|acl|promoting induces|nmod|cells induces|dobj|expression expression|nmod|END_ENTITY	N __ - methyl __ - N __ - nitro __ - N ' __ - nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2 - mediated migration .
26839895	0	CCL2	0,4	CCR2	107,111	CCL2	CCR2	6347	729230	Gene	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518 A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance .
26839895	0	CCL2	89,93	CCR2	107,111	CCL2	CCR2	6347	729230	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518 A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance .
18581322	0	CCL2	0,4	CD11b	35,40	CCL2	CD11b	6347	3684	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	CCL2 recruitment of IL-6-producing CD11b + monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity .
18855195	0	CCL2	40,44	CXCL10	22,28	CCL2	CXCL10	6347	3627	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	High values of alpha -LRB- CXCL10 -RRB- and beta -LRB- CCL2 -RRB- circulating chemokines in patients with psoriatic_arthritis , in presence or absence of autoimmune_thyroiditis .
26908203	0	CCL2	35,39	CXCL8	18,23	CCL2	CXCL8	6347	3576	Gene	Gene	IL-8|appos|START_ENTITY IL-8|appos|END_ENTITY	Induction of IL-8 -LRB- CXCL8 -RRB- and MCP-1 -LRB- CCL2 -RRB- with oxidative stress and its inhibition with N-acetyl_cysteine -LRB- NAC -RRB- in cell culture model using HK-2 cell .
21349590	0	CCL2	36,40	CXCL9	54,59	CCL2	CXCL9	6347	4283	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
17474992	0	CCL2	143,147	Ccl12	160,165	CCL2	Ccl12	20296(Tax:10090)	20293(Tax:10090)	Gene	Gene	monocyte_chemoattractant_protein-1|appos|START_ENTITY monocyte_chemoattractant_protein-1|appos|END_ENTITY	Hypoxia-inducible factor-1 -LRB- HIF-1 -RRB- is involved in the regulation of hypoxia-stimulated expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 / CCL2 -RRB- and MCP-5 -LRB- Ccl12 -RRB- in astrocytes .
12126640	0	CCL2	34,38	Ccr2	0,4	CCL2	Ccr2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	level|nmod|START_ENTITY regulates|dobj|level regulates|nsubj|END_ENTITY	Ccr2 regulates the level of MCP-1 / CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen .
22037282	0	CCL2	17,21	Chemerin	0,8	CCL2	Chemerin	6347	5919	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid_arthritis and osteoarthritis .
22037282	0	CCL2	17,21	Chemerin	0,8	CCL2	Chemerin	6347	5919	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid_arthritis and osteoarthritis .
24758146	0	CCL2	57,61	Chemerin	0,8	CCL2	Chemerin	20296(Tax:10090)	71660(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibiting|dobj|production suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	Chemerin suppresses murine allergic_asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells .
17549399	0	CCL2	38,42	GM-CSF	0,6	CCL2	GM-CSF	20296(Tax:10090)	12981(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	GM-CSF up-regulates the expression of CCL2 by T lymphocytes in mammary_tumor-bearing mice .
15119740	0	CCL2	43,47	IFN-beta	20,28	CCL2	IFN-beta	6347	3456	Gene	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Long-term effect of IFN-beta 1a therapy on CCL2 -LRB- MCP-1 -RRB- chemokine in patients with multiple_sclerosis .
22410671	0	CCL2	30,34	JNK	50,53	CCL2	JNK	24770(Tax:10116)	116554(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells .
21980379	0	CCL2	20,24	LITAF	51,56	CCL2	LITAF	20296(Tax:10090)	56722(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Novel regulation of CCL2 gene expression by murine LITAF and STAT6B .
23536638	0	CCL2	97,101	Ly-6C	76,81	CCL2	Ly-6C	20296(Tax:10090)	17067(Tax:10090)	Gene	Gene	monocytes|nmod|START_ENTITY monocytes|compound|END_ENTITY	Circulating fibrocytes prepare the lung for cancer metastasis by recruiting Ly-6C + monocytes via CCL2 .
12851645	0	CCL2	27,31	MCP-1	33,38	CCL2	MCP-1	6347	6347	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Significant involvement of CCL2 -LRB- MCP-1 -RRB- in inflammatory disorders of the lung .
17709550	0	CCL2	30,34	MCP-1	24,29	CCL2	MCP-1	6347	6347	Gene	Gene	sufficient|nsubj|START_ENTITY END_ENTITY|parataxis|sufficient	Tumor-derived chemokine MCP-1 / CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells .
20652055	0	CCL2	44,48	MCP-1	38,43	CCL2	MCP-1	20296(Tax:10090)	20296(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Rhizoma Coptidis inhibits LPS-induced MCP-1 / CCL2 production in murine macrophages via an AP-1 and NFkappaB-dependent pathway .
21029462	0	CCL2	40,44	MCP-1	34,39	CCL2	MCP-1	6347	6347	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|parataxis|contributes	Spiral ligament fibrocyte-derived MCP-1 / CCL2 contributes to inner_ear_inflammation secondary to nontypeable H. _ influenzae-induced otitis media .
21385934	0	CCL2	130,134	MCP-1	124,129	CCL2	MCP-1	6347	6347	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral_squamous_cell_carcinoma metastasis by downregulating MCP-1 / CCL2 expression .
22240432	0	CCL2	11,15	MCP-1	4,9	CCL2	MCP-1	6347	6347	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	The MCP-1 -LRB- CCL2 -RRB- -2518 GG genotype is associated with protection against pulmonary_tuberculosis in Moroccan patients .
25199511	0	CCL2	142,146	MCP-1	136,141	CCL2	MCP-1	6347	6347	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Focal_Adhesion_Kinase Knockdown in Carcinoma-Associated Fibroblasts Inhibits Oral Squamous Cell Carcinoma Metastasis via Downregulating MCP-1 / CCL2 Expression .
22138288	0	CCL2	0,4	MMP-9	15,20	CCL2	MMP-9	6347	4318	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK / ERK/NF-kB signaling pathway .
25756512	0	CCL2	60,64	PTEN	0,4	CCL2	PTEN	20296(Tax:10090)	19211(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism .
21199725	0	CCL2	136,140	THP-1	180,185	CCL2	THP-1	6347	2736	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium_bovis bacillus Calmette Gu rin -LRB- BCG -RRB- - induced CCL2 secretion in human monocytic cell line THP-1 .
23293927	0	CCL2	34,38	Tumour_necrosis_factor_a	0,24	CCL2	Tumour necrosis factor a	6347	7124	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Tumour_necrosis_factor_a enhances CCL2 and ICAM-1 expression in peripheral nerve microvascular endoneurial endothelial cells .
23954399	0	CCL2	52,56	ZXDC	37,41	CCL2	ZXDC	6347	79364	Gene	Gene	expression|nummod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression .
22378888	0	CCL2	52,56	adenosine_A3_receptor	20,41	CCL2	adenosine A3 receptor	24770(Tax:10116)	25370(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	CXCL16 orchestrates adenosine_A3_receptor and MCP-1 / CCL2 activity to protect neurons from excitotoxic cell death in the CNS .
18702954	0	CCL2	42,46	beta-chemokine	27,41	CCL2	beta-chemokine	6347	6352	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis_C-associated cryoglobulinemia in the presence or absence of autoimmune_thyroiditis .
25380884	0	CCL2	197,201	matrix_metalloproteinase_2	141,167	CCL2	matrix metalloproteinase 2	6347	4313	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	Advanced age of renal transplant recipients correlates with increased plasma concentrations of interleukin-6 , chemokine ligand 2 -LRB- CCL2 -RRB- , and matrix_metalloproteinase_2 , and urine concentrations of CCL2 and tissue inhibitor of metalloproteinase 1 .
19125409	0	CCL2	50,54	monocyte_chemoattractant_protein-1	8,42	CCL2	monocyte chemoattractant protein-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of monocyte_chemoattractant_protein-1 -LRB- MCP-1 / CCL2 -RRB- in migration of neural progenitor cells toward glial_tumors .
16410530	0	CCL2	46,50	monocyte_chemotactic_protein-1	7,37	CCL2	monocyte chemotactic protein-1	6347	6347	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Raised monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- / CCL2 in cerebrospinal fluid of patients with neuropsychiatric_lupus .
24764682	0	CCL2	45,49	monocyte_chemotactic_protein-1	14,44	CCL2	monocyte chemotactic protein-1	6347	6347	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of monocyte_chemotactic_protein-1 / CCL2 in gastric_cancer and its relationship with tumor_hypoxia .
19524871	0	CCL2	32,36	substance_P	45,56	CCL2	substance P	6347	6863	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Stimulation of CCL2 -LRB- MCP-1 -RRB- and CCL2 mRNA by substance_P in LAD2 human mast cells .
24813219	0	CCL2	104,108	toll-like_receptor_4	36,56	CCL2	toll-like receptor 4	281043(Tax:9913)	281536(Tax:9913)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Genetic polymorphisms in the bovine toll-like_receptor_4 -LRB- TLR4 -RRB- and monocyte chemo attractant protein-1 -LRB- CCL2 -RRB- genes : SNPs distribution analysis in Bos_indicus Sahiwal cattle breed .
24866282	0	CCL20	42,47	CCR6	0,4	CCL20	CCR6	20297(Tax:10090)	12458(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	CCR6 , the sole receptor for the chemokine CCL20 , promotes spontaneous intestinal tumorigenesis .
22240809	0	CCL20	16,21	FOXO1	0,5	CCL20	FOXO1	6364	2308	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	FOXO1 increases CCL20 to promote NF-kB-dependent lymphocyte chemotaxis .
16840346	0	CCL20	14,19	Flt3-L	82,88	CCL20	Flt3-L	6364	2323	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of CCL20 and granulocyte-macrophage colony-stimulating factor , but not Flt3-L , from modified vaccinia_virus ankara enhances antiviral cellular and humoral immune responses .
24902798	0	CCL20	15,20	IL-22	0,5	CCL20	IL-22	6364	50616	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	IL-22 Enhances CCL20 Production in IL-1b-Stimulated Human Gingival Fibroblasts .
20595617	0	CCL20	44,49	IL-8	26,30	CCL20	IL-8	6364	3576	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin .
23283206	0	CCL20	61,66	Interleukin-17A	81,96	CCL20	Interleukin-17A	6364	3605	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Synergistic Induction of Macrophage_Inflammatory_Protein-3a ; / CCL20 Production by Interleukin-17A and Tumor_Necrosis_Factor-a ; in Nasal Polyp Fibroblasts .
11994140	0	CCL20	44,49	MIP-3_alpha	32,43	CCL20	MIP-3 alpha	6364	6364	Gene	Gene	START_ENTITY|dep|Expression Expression|nmod|END_ENTITY	Expression of the C-C chemokine MIP-3_alpha / CCL20 in human epidermis with impaired permeability barrier function .
20400327	0	CCL20	13,18	OX40	0,4	CCL20	OX40	20297(Tax:10090)	22163(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	OX40 induces CCL20 expression in the context of antigen stimulation : an expanding role of co-stimulatory molecules in chemotaxis .
26793127	0	CCL20	43,48	SLPI	50,54	CCL20	SLPI	6364	6590	Gene	Gene	Cells|nmod|START_ENTITY Cells|nsubj|END_ENTITY	In vivo Cigarette Smoke Exposure Decreases CCL20 , SLPI , and BD-1 Secretion by Human Primary Nasal Epithelial Cells .
26536229	0	CCL20	124,129	TLR3	110,114	CCL20	TLR3	6364	7098	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory_Bowel_Disease , and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells .
11809734	0	CCL20	95,100	Tax	35,38	CCL20	Tax	6364	1491938(Tax:11908)	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Human_T_cell_leukemia_virus_type-I Tax activates human macrophage_inflammatory_protein-3_alpha / CCL20 gene transcription via the NF-kappa_B pathway .
11809734	0	CCL20	95,100	macrophage_inflammatory_protein-3_alpha	55,94	CCL20	macrophage inflammatory protein-3 alpha	6364	6364	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	Human_T_cell_leukemia_virus_type-I Tax activates human macrophage_inflammatory_protein-3_alpha / CCL20 gene transcription via the NF-kappa_B pathway .
17114436	0	CCL21	22,27	Oncostatin_M	0,12	CCL21	Oncostatin M	6366	18413(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Oncostatin_M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph_nodes .
14971049	0	CCL22	13,18	CCL17	24,29	CCL22	CCL17	6367	6361	Gene	Gene	Dominance|nmod|START_ENTITY Dominance|nmod|END_ENTITY	Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells .
14971049	0	CCL22	13,18	CCR4	65,69	CCL22	CCR4	6367	1233	Gene	Gene	Dominance|nmod|START_ENTITY Dominance|nmod|END_ENTITY	Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells .
12629149	0	CCL22	12,17	MDC	19,22	CCL22	MDC	20299(Tax:10090)	20299(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of CCL22 -LRB- MDC -RRB- for the recruitment of eosinophils during allergic_pleurisy in mice .
23005594	0	CCL22	44,49	macrophage-derived_chemokine	14,42	CCL22	macrophage-derived chemokine	6367	6367	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of macrophage-derived_chemokine -LRB- CCL22 -RRB- in atherosclerosis and regulation by histamine via the H2 receptor .
15927850	0	CCL23	19,24	CCR1	39,43	CCL23	CCR1	6368	1230	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Human CC chemokine CCL23 , a ligand for CCR1 , induces endothelial cell migration and promotes angiogenesis .
19951712	0	CCL23	10,15	CK_beta_8	0,9	CCL23	CK beta 8	6368	6368	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	CK_beta_8 / CCL23 induces cell migration via the Gi/Go _ protein/PLC/PKC _ delta/NF-kappa _ B and is involved in inflammatory responses .
10737895	0	CCL23	10,15	CKbeta-8	0,8	CCL23	CKbeta-8	6368	6368	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	CKbeta-8 -LSB- CCL23 -RSB- , a novel CC chemokine , is chemotactic for human osteoclast precursors and is expressed in bone tissues .
16378600	0	CCL23	19,24	matrix_metalloproteinase-2	48,74	CCL23	matrix metalloproteinase-2	6368	4313	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Human CC chemokine CCL23 enhances expression of matrix_metalloproteinase-2 and invasion of vascular endothelial cells .
16682802	0	CCL24	52,57	eotaxin-2	41,50	CCL24	eotaxin-2	6369	6369	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Endothelial and epithelial expression of eotaxin-2 -LRB- CCL24 -RRB- in nasal_polyps .
17917245	0	CCL24	39,44	eotaxin-2	29,38	CCL24	eotaxin-2	6369	6369	Gene	Gene	Production|dep|START_ENTITY Production|nmod|END_ENTITY	Production and regulation of eotaxin-2 / CCL24 in a differentiated human leukemic cell line , HT93 .
11751956	0	CCL25	197,202	CCR9	20,24	CCL25	CCR9	20300(Tax:10090)	12769(Tax:10090)	Gene	Gene	respond|nmod|START_ENTITY CD69|ccomp|respond _|parataxis|CD69 _|nsubj|Characterization Characterization|nmod|expression expression|compound|END_ENTITY	Characterization of CCR9 expression and CCL25/thymus-expressed _ chemokine responsiveness during T cell development : CD3 -LRB- high -RRB- CD69 + thymocytes and gammadeltaTCR + thymocytes preferentially respond to CCL25 .
12096027	0	CCL25	16,21	CCR9	29,33	CCL25	CCR9	20300(Tax:10090)	12769(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Pivotal role of CCL25 -LRB- TECK -RRB- - CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes .
15557349	0	CCL25	20,25	CCR9	54,58	CCL25	CCR9	6370	10803	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|recruitment recruitment|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Hepatic endothelial CCL25 mediates the recruitment of CCR9 + gut-homing lymphocytes to the liver in primary sclerosing cholangitis .
20504763	0	CCL25	125,130	CCR9	98,102	CCL25	CCR9	20300(Tax:10090)	12769(Tax:10090)	Gene	Gene	down-regulates|appos|START_ENTITY down-regulates|dep|END_ENTITY	Angiotensin-converting_enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 -LRB- CCR9 -RRB- - chemokine ligand 25 -LRB- CCL25 -RRB- axis .
21295855	0	CCL25	79,84	CCR9	20,24	CCL25	CCR9	6370	10803	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	Specific killing of CCR9 high-expressing acute T_lymphocytic_leukemia cells by CCL25 fused with PE38 toxin .
15681774	0	CCL25	0,5	E-cadherin	53,63	CCL25	E-cadherin	6370	999	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	CCL25 enhances CD103-mediated lymphocyte adhesion to E-cadherin .
18308860	0	CCL25	0,5	MAdCAM-1	83,91	CCL25	MAdCAM-1	6370	8174	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|END_ENTITY	CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow .
12442331	0	CCL25	15,20	TECK	22,26	CCL25	TECK	20300(Tax:10090)	20300(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of CCL25 -LRB- TECK -RRB- in the generation of the murine small-intestinal CD8alpha alpha + CD3 + intraepithelial lymphocyte compartment .
23679817	0	CCL26	150,155	CCL11	157,162	CCL26	CCL11	10344	6356	Gene	Gene	IL-8|compound|START_ENTITY IL-8|appos|END_ENTITY	Inhibition by new glucocorticoid antedrugs -LSB- 16a , 17a-d -RSB- isoxazoline and -LSB- 16a , _ 17a-d -RSB- -3 ' - hydroxy-iminoformyl_isoxazoline derivatives of chemotaxis and CCL26 , CCL11 , IL-8 , and RANTES secretion .
15039444	0	CCL26	10,15	CC_chemokine_receptors_1_and_5	44,74	CCL26	CC chemokine receptors 1 and 5	10344	1234	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Eotaxin-3 / CCL26 is a natural antagonist for CC_chemokine_receptors_1_and_5 .
15589317	0	CCL26	73,78	Eotaxin-3	63,72	CCL26	Eotaxin-3	10344	10344	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3 / CCL26 gene expression in HEK293 cells .
26418908	0	CCL26	11,16	Eotaxin-3	0,9	CCL26	Eotaxin-3	10344	10344	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Eotaxin-3 -LRB- CCL26 -RRB- Expression in Human Pancreatic Myofibroblasts .
15589317	0	CCL26	73,78	IL-4	26,30	CCL26	IL-4	10344	3565	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression induced|dobj|activation END_ENTITY|acl|induced	SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3 / CCL26 gene expression in HEK293 cells .
18774776	0	CCL26	9,14	IL-4	83,87	CCL26	IL-4	10344	3565	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|receptor receptor|compound|END_ENTITY	Enhanced CCL26 production by IL-4 through IFN-gamma-induced upregulation of type 1 IL-4 receptor in keratinocytes .
19038554	0	CCL26	91,96	IL-4	53,57	CCL26	IL-4	10344	3565	Gene	Gene	eotaxin-3|appos|START_ENTITY release|nmod|eotaxin-3 stimulated|dobj|release END_ENTITY|acl|stimulated	Post-transcriptional silencing of CCR3 downregulates IL-4 stimulated release of eotaxin-3 -LRB- CCL26 -RRB- and other CCR3 ligands in alveolar type II cells .
20229526	0	CCL26	88,93	IL-4	72,76	CCL26	IL-4	10344	3565	Gene	Gene	secretion|nummod|START_ENTITY stimulated|dobj|secretion END_ENTITY|acl|stimulated	Blackcurrant proanthocyanidins augment IFN-gamma-induced suppression of IL-4 stimulated CCL26 secretion in alveolar epithelial cells .
22226123	0	CCL26	25,30	IL-4	0,4	CCL26	IL-4	10344	3565	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1 , 2/Stat6 signal transduction pathway : Implication for atopic_dermatitis .
16755001	0	CCL26	57,62	eotaxin-1	27,36	CCL26	eotaxin-1	10344	6356	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of eotaxin-1 / CCL11 and eotaxin-3 / CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast .
14616792	0	CCL26	51,56	eotaxin-2	69,78	CCL26	eotaxin-2	10344	6369	Gene	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	Significant elevation of serum levels of eotaxin-3 / CCL26 , but not of eotaxin-2 / CCL24 , in patients with atopic_dermatitis : serum eotaxin-3 / CCL26 levels reflect the disease activity of atopic_dermatitis .
12061839	0	CCL26	30,35	eotaxin-3	20,29	CCL26	eotaxin-3	10344	10344	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of human eotaxin-3 / CCL26 expression : modulation by cytokines and glucocorticoids .
14616792	0	CCL26	138,143	eotaxin-3	41,50	CCL26	eotaxin-3	10344	10344	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Significant elevation of serum levels of eotaxin-3 / CCL26 , but not of eotaxin-2 / CCL24 , in patients with atopic_dermatitis : serum eotaxin-3 / CCL26 levels reflect the disease activity of atopic_dermatitis .
18844613	0	CCL26	83,88	eotaxin-3	73,82	CCL26	eotaxin-3	10344	10344	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Treatment with topical steroids downregulates IL-5 , eotaxin-1 / CCL11 , and eotaxin-3 / CCL26 gene expression in eosinophilic_esophagitis .
18811584	0	CCL27	111,116	CCR4	125,129	CCL27	CCR4	10850	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCL27	111,116	CCR5	131,135	CCL27	CCR5	10850	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCL27	111,116	CXCR3	137,142	CCL27	CXCR3	10850	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCL27	111,116	IFN-beta	161,169	CCL27	IFN-beta	10850	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCL27	111,116	IP-10	118,123	CCL27	IP-10	10850	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCL27	111,116	MIP-1alpha	99,109	CCL27	MIP-1alpha	10850	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
15466853	0	CCL27	93,98	P-selectin_glycoprotein_ligand-1	6,38	CCL27	P-selectin glycoprotein ligand-1	10850	6404	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus .
18811584	0	CCL27	111,116	PD1	144,147	CCL27	PD1	10850	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCL27	111,116	PDL2	149,153	CCL27	PDL2	10850	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
12642842	0	CCL27	55,60	cutaneous_T_cell-attracting_chemokine	16,53	CCL27	cutaneous T cell-attracting chemokine	10850	10850	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increased serum cutaneous_T_cell-attracting_chemokine -LRB- CCL27 -RRB- levels in patients with atopic_dermatitis and psoriasis_vulgaris .
21447959	0	CCL28	15,20	IL-17A	0,6	CCL28	IL-17A	56477	3605	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-17A induces CCL28 , supporting the chemotaxis of IgE-secreting B cells .
16581045	0	CCL28	54,59	IL-1beta	0,8	CCL28	IL-1beta	56477	3553	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFkappaB-dependent pathway .
21753853	0	CCL28	55,60	reg	67,70	CCL28	reg	56477	5967	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tumour_hypoxia promotes tolerance and angiogenesis via CCL28 and T -LRB- reg -RRB- cells .
23615158	0	CCL3	67,71	5-lipoxygenase	26,40	CCL3	5-lipoxygenase	20302(Tax:10090)	11689(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Atorvastatin inhibits the 5-lipoxygenase pathway and expression of CCL3 to alleviate atherosclerotic_lesions in atherosclerotic ApoE knockout mice .
21349590	0	CCL3	42,46	CCL2	36,40	CCL3	CCL2	6348	6347	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
23143790	0	CCL3	28,32	CCL2	47,51	CCL3	CCL2	20302(Tax:10090)	20296(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|mice mice|amod|END_ENTITY	Hyperocclusion up-regulates CCL3 expression in CCL2 - and CCR2-deficient mice .
26133170	0	CCL3	16,20	CCL2	10,14	CCL3	CCL2	25542(Tax:10116)	24770(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
26133170	0	CCL3	16,20	CCL2	10,14	CCL3	CCL2	25542(Tax:10116)	24770(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
16197470	0	CCL3	116,120	CCL5	96,100	CCL3	CCL5	6348	6352	Gene	Gene	internalization|nmod|START_ENTITY internalization|nmod|END_ENTITY	Differential pattern of CCR1 internalization in human eosinophils : prolonged internalization by CCL5 in contrast to CCL3 .
21349590	0	CCL3	42,46	CCL5	48,52	CCL3	CCL5	6348	6352	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
26133170	0	CCL3	16,20	CCL5	22,26	CCL3	CCL5	25542(Tax:10116)	81780(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
26133170	0	CCL3	16,20	CCL5	22,26	CCL3	CCL5	25542(Tax:10116)	81780(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
21349590	0	CCL3	42,46	CXCL9	54,59	CCL3	CXCL9	6348	4283	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
18619972	0	CCL3	0,4	MIP-1_alpha	6,17	CCL3	MIP-1 alpha	6348	6348	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	CCL3 -LRB- MIP-1_alpha -RRB- levels are elevated during acute_coronary_syndromes and show strong prognostic power for future ischemic events .
21403648	0	CCL3	17,21	MIP-1a	23,29	CCL3	MIP-1a	6348	6348	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for CCL3 -LRB- MIP-1a -RRB- in myeloma-induced bone_disease via osteocalcin downregulation and inhibition of osteoblast function .
15831559	0	CCL3	11,15	MIP-1alpha	0,10	CCL3	MIP-1alpha	20302(Tax:10090)	20302(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	MIP-1alpha -LSB- CCL3 -RSB- acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4 .
22403253	0	CCL3	62,66	NKp30	14,19	CCL3	NKp30	6348	259197	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|Engagement Engagement|nmod|END_ENTITY	Engagement of NKp30 on V 1 T cells induces the production of CCL3 , CCL4 , and CCL5 and suppresses HIV-1 replication .
18164590	0	CCL3	124,128	Tumor_necrosis_factor-alpha	0,27	CCL3	Tumor necrosis factor-alpha	6348	7124	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- induces integrin CD11b/CD18 -LRB- Mac-1 -RRB- up-regulation and migration to the CC chemokine CCL3 -LRB- MIP-1alpha -RRB- on human neutrophils through defined signalling pathways .
12488501	0	CCL3	60,64	macrophage_inflammatory_protein_1alpha	21,59	CCL3	macrophage inflammatory protein 1alpha	20302(Tax:10090)	20302(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	An essential role of macrophage_inflammatory_protein_1alpha / CCL3 on the expression of host 's innate immunities against infectious_complications .
17121222	0	CCL3L1	66,72	glutathione-S-transferase_fusion_protein	15,55	CCL3L1	glutathione-S-transferase fusion protein	6349	6294	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	-LSB- Expression of glutathione-S-transferase_fusion_protein and human CCL3L1 protein -RSB- .
16982098	0	CCL4	69,73	Activating_transcription_factor_3	0,33	CCL4	Activating transcription factor 3	20303(Tax:10090)	11910(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Activating_transcription_factor_3 -LRB- ATF3 -RRB- represses the expression of CCL4 in murine macrophages .
20599874	0	CCL4	144,148	CCL2	95,99	CCL4	CCL2	6351	6347	Gene	Gene	monocyte_chemoattractant_protein-1|appos|START_ENTITY monocyte_chemoattractant_protein-1|appos|END_ENTITY	3-hydroxyanthranilic_acid is independently associated with monocyte_chemoattractant_protein-1 -LRB- CCL2 -RRB- and macrophage_inflammatory_protein-1beta -LRB- CCL4 -RRB- in patients with chronic_kidney_disease .
19620252	0	CCL4	72,76	MIP-1beta	62,71	CCL4	MIP-1beta	6351	6351	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta / CCL4 signaling and chemotaxis of primary human macrophages .
19103522	0	CCL4	23,27	Prokineticin_1	0,14	CCL4	Prokineticin 1	6351	84432	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Prokineticin_1 induces CCL4 , CXCL1 and CXCL8 in human monocytes but not in macrophages and dendritic cells .
26786659	0	CCL4	94,98	Yin-Yang-1	16,26	CCL4	Yin-Yang-1	6351	7528	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A novel role of Yin-Yang-1 in pulmonary_tuberculosis through the regulation of the chemokine CCL4 .
21814216	0	CCL5	34,38	Angiotensin_II	0,14	CCL5	Angiotensin II	81780(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits chemokine CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats .
21349590	0	CCL5	48,52	CCL2	36,40	CCL5	CCL2	6352	6347	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
26133170	0	CCL5	22,26	CCL2	10,14	CCL5	CCL2	81780(Tax:10116)	24770(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
26133170	0	CCL5	22,26	CCL2	10,14	CCL5	CCL2	81780(Tax:10116)	24770(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
16197470	0	CCL5	96,100	CCL3	116,120	CCL5	CCL3	6352	6348	Gene	Gene	internalization|nmod|START_ENTITY internalization|nmod|END_ENTITY	Differential pattern of CCR1 internalization in human eosinophils : prolonged internalization by CCL5 in contrast to CCL3 .
21349590	0	CCL5	48,52	CCL3	42,46	CCL5	CCL3	6352	6348	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
26133170	0	CCL5	22,26	CCL3	16,20	CCL5	CCL3	81780(Tax:10116)	25542(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
26133170	0	CCL5	22,26	CCL3	16,20	CCL5	CCL3	81780(Tax:10116)	25542(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased CCL2 , CCL3 , CCL5 , and IL-1b cytokine concentration in piriform cortex , hippocampus , and neocortex after pilocarpine-induced seizures .
17893273	0	CCL5	56,60	CC_chemokine_ligand-5	33,54	CCL5	CC chemokine ligand-5	20304(Tax:10090)	20304(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Y-box_binding_protein-1 controls CC_chemokine_ligand-5 -LRB- CCL5 -RRB- expression in smooth muscle cells and contributes to neointima_formation in atherosclerosis-prone mice .
19288016	0	CCL5	114,118	CD24	64,68	CCL5	CD24	6352	100133941	Gene	Gene	expression|compound|START_ENTITY cells|nmod|expression phenotype|nmod|cells END_ENTITY|dep|phenotype	Role of CCL5 in invasion , proliferation and proportion of CD44 + / CD24 - phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast_cancer progression .
19288016	0	CCL5	8,12	CD24	64,68	CCL5	CD24	6352	100133941	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of CCL5 in invasion , proliferation and proportion of CD44 + / CD24 - phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast_cancer progression .
21349590	0	CCL5	48,52	CXCL9	54,59	CCL5	CXCL9	6352	4283	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
24523572	0	CCL5	24,28	IFN-y	86,91	CCL5	IFN-y	6352	3458	Gene	Gene	synthesis|compound|START_ENTITY Regulation|nmod|synthesis Regulation|dep|role role|nmod|END_ENTITY	Regulation of chemokine CCL5 synthesis in human_peritoneal_fibroblasts : a key role of IFN-y .
24656930	0	CCL5	19,23	IL-10	0,5	CCL5	IL-10	81780(Tax:10116)	25325(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats .
25971630	0	CCL5	0,4	IL-10	17,22	CCL5	IL-10	81780(Tax:10116)	25325(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	CCL5 upregulates IL-10 expression and partially mediates the antihypertensive effects of IL-10 in the vascular smooth muscle cells of spontaneously hypertensive rats .
25280942	0	CCL5	22,26	IL-32	0,5	CCL5	IL-32	6352	9235	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	IL-32 downregulates CCL5 expression through its interaction with PKC and STAT3 .
12555673	0	CCL5	8,12	RANTES	0,6	CCL5	RANTES	6352	6352	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	RANTES -LRB- CCL5 -RRB- production during primary respiratory_syncytial_virus_infection exacerbates airway_disease .
16628506	0	CCL5	37,41	RANTES	43,49	CCL5	RANTES	6352	6352	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	-LSB- Concentration of the beta-chemokine CCL5 -LRB- RANTES -RRB- in cerebrospinal fluid in patients with tick-borne_encephalitis -RSB- .
16873271	0	CCL5	8,12	RANTES	14,20	CCL5	RANTES	6352	6352	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of CCL5 -LRB- RANTES -RRB- in viral_lung_disease .
18956302	0	CCL5	36,40	RANTES	28,34	CCL5	RANTES	6352	6352	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and secretion of RANTES -LRB- CCL5 -RRB- in human adipocytes in response to immunological stimuli and hypoxia .
24468005	0	CCL5	37,41	RANTES	29,35	CCL5	RANTES	6352	6352	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and expression of RANTES -LRB- CCL5 -RRB- by human disc cells and modulation by IL-1-b and TNF-a in 3D culture .
26105364	1	CCL5	29,33	RANTES	21,27	CCL5	RANTES	6352	6352	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of RANTES -LRB- CCL5 -RRB- in maternal plasma , fetal plasma and placenta in pre-eclampsia and normotensive controls .
26375811	0	CCL5	15,19	RKIP	0,4	CCL5	RKIP	6352	5037	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RKIP regulates CCL5 expression to inhibit breast_cancer invasion and metastasis by controlling macrophage infiltration .
19124744	0	CCL5	57,61	SP1	88,91	CCL5	SP1	6352	6667	Gene	Gene	transcription|nmod|START_ENTITY regulates|dobj|transcription regulates|nmod|END_ENTITY	JNK MAPK pathway regulates constitutive transcription of CCL5 by human NK cells through SP1 .
25231320	0	CCL5	50,54	STAT3	84,89	CCL5	STAT3	6352	6774	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Tunicamycin-induced ER stress regulates chemokine CCL5 expression and secretion via STAT3 followed by decreased transmigration of MCF-7 breast_cancer cells .
26983899	0	CCL5	18,22	STAT3	113,118	CCL5	STAT3	6352	6774	Gene	Gene	secretion|compound|START_ENTITY promotes|nsubj|secretion promotes|xcomp|cisplatin-resistance cisplatin-resistance|nmod|ovarian_cancer ovarian_cancer|nmod|regulation regulation|nmod|END_ENTITY	Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovarian_cancer via regulation of the STAT3 and PI3K/Akt signaling pathways .
21658938	0	CCL5	21,25	TGFb1	61,66	CCL5	TGFb1	6352	7040	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	Relationship between CCL5 and transforming_growth_factor-b1 -LRB- TGFb1 -RRB- in breast_cancer .
20523058	0	CCL5	26,30	TLR3	45,49	CCL5	TLR3	6352	7098	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	Cooperative activation of CCL5 expression by TLR3 and tumor_necrosis_factor-alpha or interferon-gamma through nuclear factor-kappaB or STAT-1 in airway epithelial cells .
15239133	0	CCL5	99,103	tax	147,150	CCL5	tax	6352	1491938(Tax:11908)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Elevated expression of CCL5/RANTES in adult_T-cell_leukemia cells : possible transactivation of the CCL5 gene by human_T-cell_leukemia_virus_type_I tax .
25444917	0	CCL5	0,4	vascular_endothelial_growth_factor	14,48	CCL5	vascular endothelial growth factor	6352	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	CCL5 promotes vascular_endothelial_growth_factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells .
16087246	0	CCL6	25,29	CCL6	67,71	CCL6	CCL6	287910(Tax:10116)	287910(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Functional expression of CCL6 by rat microglia : a possible role of CCL6 in cell-cell communication .
16087246	0	CCL6	67,71	CCL6	25,29	CCL6	CCL6	287910(Tax:10116)	287910(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Functional expression of CCL6 by rat microglia : a possible role of CCL6 in cell-cell communication .
25413039	0	CCM1	105,109	KRIT-1	97,103	CCM1	KRIT-1	889	889	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Cerebral_Cavernous_Malformations and Unilateral Moyamoya in a Patient with a New Mutation in the KRIT-1 / CCM1 Gene .
11161805	0	CCM1	96,100	KRIT1	89,94	CCM1	KRIT1	889	889	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 -LRB- CCM1 -RRB- gene .
17699553	0	CCN1	14,18	CYR61	20,25	CCN1	CYR61	3491	3491	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CCN1 -LRB- CYR61 -RRB- in developing , normal , and diseased human kidney .
17608974	0	CCN1	57,61	CYR_61	63,69	CCN1	CYR 61	3491	3491	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effects of schizophrenomimetics on the expression of the CCN1 -LRB- CYR_61 -RRB- gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat .
22566095	0	CCN1	26,30	Cysteine-rich_protein_61	0,24	CCN1	Cysteine-rich protein 61	3491	3491	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Cysteine-rich_protein_61 -LRB- CCN1 -RRB- mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts .
21945803	0	CCN1	20,24	Substance_P	0,11	CCN1	Substance P	3491	6863	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Substance_P induces CCN1 expression via histone_deacetylase activity in human colonic epithelial cells .
22701179	0	CCN1	0,4	b-Catenin	13,22	CCN1	b-Catenin	890	1499	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	CCN1 Induces b-Catenin Translocation in Esophageal_Squamous_Cell_Carcinoma through Integrin a11 .
24895995	0	CCN1	34,38	cysteine-rich_61_protein	8,32	CCN1	cysteine-rich 61 protein	3491	3491	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of cysteine-rich_61_protein -LRB- CCN1 -RRB- in macrophage-mediated oncolytic herpes simplex virus clearance .
15308622	0	CCN1	63,67	integrin_alphavbeta3	26,46	CCN1	integrin alphavbeta3	3491	3685	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Identification of a novel integrin_alphavbeta3 binding site in CCN1 -LRB- CYR61 -RRB- critical for pro-angiogenic activities in vascular endothelial cells .
25187949	0	CCN1	0,4	oncostatin_M	13,25	CCN1	oncostatin M	3491	5008	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	CCN1 induces oncostatin_M production in osteoblasts via integrin-dependent signal pathways .
25185742	0	CCN2	35,39	Cdc42	0,5	CCN2	Cdc42	1490	998	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Cdc42 and p190RhoGAP activation by CCN2 regulates cell spreading and polarity and induces actin disassembly in migrating keratinocytes .
16790529	0	CCN2	32,36	Connective_tissue_growth_factor	0,31	CCN2	Connective tissue growth factor	1490	1490	Gene	Gene	stimulates|nsubj|START_ENTITY END_ENTITY|parataxis|stimulates	Connective_tissue_growth_factor / CCN2 stimulates actin disassembly through Akt/protein _ kinase_B-mediated phosphorylation and cytoplasmic translocation of p27 -LRB- Kip-1 -RRB- .
24155087	0	CCN2	27,31	ERK1/2	68,74	CCN2	ERK1/2	1490	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway .
21760921	0	CCN2	0,4	TGF-b	25,30	CCN2	TGF-b	1490	7040	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	CCN2 is required for the TGF-b induced activation of Smad1-Erk1 / 2 signaling network .
25354561	0	CCN2	0,4	TGF-b	14,19	CCN2	TGF-b	14219(Tax:10090)	21803(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	CCN2 requires TGF-b signalling to regulate CCAAT/enhancer binding proteins and inhibit fat cell differentiation .
26340021	0	CCN2	51,55	TGF-b1	40,46	CCN2	TGF-b1	14219(Tax:10090)	21803(Tax:10090)	Gene	Gene	Induction|compound|START_ENTITY END_ENTITY|nmod|Induction	AFAP1 Is a Novel Downstream Mediator of TGF-b1 for CCN2 Induction in Osteoblasts .
17376761	0	CCN2	40,44	TNF-alpha	0,9	CCN2	TNF-alpha	1490	7124	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TNF-alpha , but not IFN-gamma , regulates CCN2 -LRB- CTGF -RRB- , collagen type I , and proliferation in mesangial cells : possible roles in the progression of renal_fibrosis .
19353303	0	CCN2	22,26	Wnt_10b	0,7	CCN2	Wnt 10b	1490	7480	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Wnt_10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element .
11577177	0	CCN2	57,61	connective_tissue_growth_factor	24,55	CCN2	connective tissue growth factor	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Steroidal regulation of connective_tissue_growth_factor -LRB- CCN2 ; CTGF -RRB- synthesis in the mouse uterus .
15047749	0	CCN2	47,51	connective_tissue_growth_factor	14,45	CCN2	connective tissue growth factor	1490	1490	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of connective_tissue_growth_factor -LRB- CCN2 -RRB- in desmoplastic_small_round_cell_tumour .
15855807	0	CCN2	51,55	connective_tissue_growth_factor	18,49	CCN2	connective tissue growth factor	1490	1490	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	TGF-beta1-induced connective_tissue_growth_factor -LRB- CCN2 -RRB- expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling .
19280452	0	CCN2	64,68	connective_tissue_growth_factor	31,62	CCN2	connective tissue growth factor	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Ethanol-mediated expression of connective_tissue_growth_factor -LRB- CCN2 -RRB- in mouse pancreatic_stellate_cells .
24413988	0	CCN2	75,79	connective_tissue_growth_factor	81,112	CCN2	connective tissue growth factor	1490	1490	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	BMP9 inhibits the bone metastasis of breast_cancer cells by downregulating CCN2 -LRB- connective_tissue_growth_factor , CTGF -RRB- expression .
24882759	0	CCN2	91,95	connective_tissue_growth_factor	58,89	CCN2	connective tissue growth factor	1490	1490	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|END_ENTITY	Exosomes mediate intercellular transfer of pro-fibrogenic connective_tissue_growth_factor -LRB- CCN2 -RRB- between hepatic stellate cells , the principal fibrotic cells in the liver .
16484225	0	CCN2	0,4	transforming_growth_factor-beta1	44,76	CCN2	transforming growth factor-beta1	14219(Tax:10090)	21803(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	CCN2 is necessary for adhesive responses to transforming_growth_factor-beta1 in embryonic fibroblasts .
16670264	0	CCN3	62,66	BCR-ABL	22,29	CCN3	BCR-ABL	4856	25	Gene	Gene	secretion|nmod|START_ENTITY stimulated|dobj|secretion action|acl|stimulated action|amod|END_ENTITY	A novel mechanism for BCR-ABL action : stimulated secretion of CCN3 is involved in growth and differentiation regulation .
21638198	0	CCN3	73,77	BCR-ABL	34,41	CCN3	BCR-ABL	4856	25	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	MicroRNAs 130a/b are regulated by BCR-ABL and downregulate expression of CCN3 in CML .
21898398	0	CCN3	0,4	BMP-4	15,20	CCN3	BMP-4	4856	652	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	CCN3 increases BMP-4 expression and bone mineralization in osteoblasts .
17101694	0	CCN3	0,4	DDR1	79,83	CCN3	DDR1	4856	780	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1 .
24308033	0	CCN3	26,30	NOTCH1	41,47	CCN3	NOTCH1	4856	4851	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The matricellular protein CCN3 regulates NOTCH1 signalling in chronic_myeloid_leukaemia .
21618206	0	CCN3	38,42	Transforming_growth_factor_b	0,28	CCN3	Transforming growth factor b	18133(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Transforming_growth_factor_b controls CCN3 expression in nucleus pulposus cells of the intervertebral disc .
23343403	0	CCN4	0,4	IL-6	13,17	CCN4	IL-6	8840	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	CCN4 induces IL-6 production through avb5 receptor , PI3K , Akt , and NF-kB singling pathway in human synovial fibroblasts .
20684029	0	CCN4	7,11	WISP-1	0,6	CCN4	WISP-1	8840	8840	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	WISP-1 / CCN4 regulates osteogenesis by enhancing BMP-2 activity .
23313051	0	CCN4	0,4	vascular_cell_adhesion_molecule-1	13,46	CCN4	vascular cell adhesion molecule-1	8840	7412	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	CCN4 induces vascular_cell_adhesion_molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion .
15798095	0	CCN5	39,43	Epidermal_growth_factor	0,23	CCN5	Epidermal growth factor	8839	1950	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces WISP-2 / CCN5 expression in estrogen_receptor-alpha-positive breast_tumor cells through multiple molecular cross-talks .
17308090	0	CCN5	52,56	Insulin-like_growth_factor-1	0,28	CCN5	Insulin-like growth factor-1	8839	3479	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- induces WISP-2 / CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen_receptor-positive breast_tumor cells .
15706414	0	CCN5	95,99	WISP-2	88,94	CCN5	WISP-2	22403(Tax:10090)	22403(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Stimulation of MCF-7 tumor progression in athymic nude_mice by 17beta-estradiol induces WISP-2 / CCN5 expression in xenografts : a novel signaling molecule in hormonal carcinogenesis .
15798095	0	CCN5	39,43	WISP-2	32,38	CCN5	WISP-2	8839	8839	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Epidermal_growth_factor induces WISP-2 / CCN5 expression in estrogen_receptor-alpha-positive breast_tumor cells through multiple molecular cross-talks .
18070926	0	CCN5	15,19	WISP-2	8,14	CCN5	WISP-2	8839	8839	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of WISP-2 / CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast_cancer cells .
21391218	0	CCN6	0,4	ICAM-1	14,20	CCN6	ICAM-1	8838	3383	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells .
16457688	0	CCN6	14,18	WISP3	20,25	CCN6	WISP3	8838	8838	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Inhibition of CCN6 -LRB- WISP3 -RRB- expression promotes neoplastic progression and enhances the effects of insulin-like_growth_factor-1 on breast epithelial cells .
18321996	0	CCN6	14,18	Wnt-1-induced_signaling_protein_3	20,53	CCN6	Wnt-1-induced signaling protein 3	8838	8838	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of CCN6 -LRB- Wnt-1-induced_signaling_protein_3 -RRB- down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1 .
22294415	0	CCN6	111,115	Wnt-1-inducible_signaling_pathway_protein_3	67,110	CCN6	Wnt-1-inducible signaling pathway protein 3	8838	8838	Gene	Gene	regulation|parataxis|START_ENTITY regulation|nmod|END_ENTITY	Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible_signaling_pathway_protein_3 / CCN6 .
1386686	0	CCNB1	22,27	cyclin_B1	6,15	CCNB1	cyclin B1	891	891	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human cyclin_B1 gene -LRB- CCNB1 -RRB- assigned to chromosome 5 -LRB- q13-qter -RRB- .
18713830	0	CCND1	38,43	CREB	20,24	CCND1	CREB	595	1385	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	VRK1 phosphorylates CREB and mediates CCND1 expression .
12955092	0	CCND1	16,21	Cyclin_D1	0,9	CCND1	Cyclin D1	595	595	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cyclin_D1 gene -LRB- CCND1 -RRB- mutations in endometrial_cancer .
16258756	0	CCND1	16,21	Cyclin_D1	0,9	CCND1	Cyclin D1	595	595	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cyclin_D1 gene -LRB- CCND1 -RRB- polymorphism and the risk of squamous_cell_carcinoma of the larynx .
23060014	0	CCND1	11,16	Cyclin_D1	0,9	CCND1	Cyclin D1	595	595	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclin_D1 -LRB- CCND1 -RRB- expression is involved in estrogen receptor beta -LRB- ERb -RRB- in human prostate_cancer .
24060591	0	CCND1	11,16	Cyclin_D1	0,9	CCND1	Cyclin D1	595	595	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Cyclin_D1 -LRB- CCND1 -RRB- messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle_cell_lymphoma .
26979757	0	CCND1	67,72	Cyclin_D1	51,60	CCND1	Cyclin D1	595	595	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association Between Polymorphism rs678653 in Human Cyclin_D1 Gene -LRB- CCND1 -RRB- and Susceptibility to Cancer : A Meta-Analysis .
26840018	0	CCND1	20,25	Hsa-miR-326	0,11	CCND1	Hsa-miR-326	595	442900	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Hsa-miR-326 targets CCND1 and inhibits non-small_cell_lung_cancer development .
14514791	0	CCND1	17,22	IgH	37,40	CCND1	IgH	595	3495	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle_lymphoma with normal chromosomes 11 and 14 .
25450356	0	CCND1	110,115	MicroRNA-383	0,12	CCND1	MicroRNA-383	595	494332	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-383 inhibits anchorage-independent growth and induces cell cycle arrest of glioma cells by targeting CCND1 .
26695908	0	CCND1	36,41	PNKP	47,51	CCND1	PNKP	595	11284	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Expression of Cyclin_d1 protein and CCND1 PNKP genes in peripheral blood mononuclear cells in clean up worker of Chornobyl accident with different state of immune system .
8547115	0	CCND1	35,40	PRAD-1	28,34	CCND1	PRAD-1	595	595	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Increased expression of the PRAD-1 / CCND1 gene in hairy_cell_leukaemia .
19084934	0	CCND1	30,35	Tp53	17,21	CCND1	Tp53	595	7157	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Tissue array for Tp53 , C-myc , CCND1 gene over-expression in different tumors .
12557224	0	CCND1	54,59	cyclin_D1	43,52	CCND1	cyclin D1	595	595	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Rearrangements and increased expression of cyclin_D1 -LRB- CCND1 -RRB- in neuroblastoma .
16829689	0	CCND1	29,34	cyclin_D1	18,27	CCND1	cyclin D1	595	595	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The effect of the cyclin_D1 -LRB- CCND1 -RRB- A870G polymorphism on colorectal_cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health Study .
23873109	0	CCND1	15,20	cyclin_D1	4,13	CCND1	cyclin D1	595	595	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The cyclin_D1 -LRB- CCND1 -RRB- G870A polymorphism and lung_cancer susceptibility : a meta-analysis .
25227811	0	CCND1	13,18	cyclin_D1	2,11	CCND1	cyclin D1	595	595	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	A cyclin_D1 -LRB- CCND1 -RRB- gene polymorphism contributes to susceptibility to papillary_thyroid_cancer in the Turkish population .
8562333	0	CCND1	27,32	cyclin_D1	34,43	CCND1	cyclin D1	595	595	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of CCND1 -LRB- cyclin_D1 -RRB- overexpression in primary resected non-small-cell_lung_cancer .
9813719	0	CCND1	51,56	cyclin_D1	58,67	CCND1	cyclin D1	595	595	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A differential PCR system for the determination of CCND1 -LRB- cyclin_D1 -RRB- gene amplification in head_and_neck_squamous_cell_carcinomas .
18406353	0	CCND1	18,23	miR-34a	36,43	CCND1	miR-34a	595	407040	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest .
23674142	0	CCND1	96,101	miR-449b	0,8	CCND1	miR-449b	595	693123	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression inhibits|nmod|downregulation inhibits|nsubj|END_ENTITY	miR-449b inhibits the proliferation of SW1116 colon_cancer stem cells through downregulation of CCND1 and E2F3 expression .
1387066	0	CCND3	40,45	cyclin_D3	24,33	CCND3	cyclin D3	896	896	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human cyclin_D3 gene -LRB- CCND3 -RRB- to chromosome 6p -- q13 .
7896286	0	CCNF	21,25	cyclin	8,14	CCNF	cyclin	899	5111	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel cyclin gene -LRB- CCNF -RRB- in the region of the polycystic_kidney_disease gene -LRB- PKD1 -RRB- .
24708911	0	CCNG2	0,5	insulin	34,41	CCNG2	insulin	901	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	CCNG2 and CDK4 is associated with insulin resistance in adipose tissue .
26305884	0	CCNYL1	0,6	CDK16	38,43	CCNYL1	CDK16	227210(Tax:10090)	18555(Tax:10090)	Gene	Gene	Cooperates|nsubj|START_ENTITY Cooperates|nmod|END_ENTITY	CCNYL1 , but Not CCNY , Cooperates with CDK16 to Regulate Spermatogenesis in Mouse .
26305884	0	CCNYL1	0,6	CDK16	38,43	CCNYL1	CDK16	227210(Tax:10090)	18555(Tax:10090)	Gene	Gene	Cooperates|nsubj|START_ENTITY Cooperates|nmod|END_ENTITY	CCNYL1 , but Not CCNY , Cooperates with CDK16 to Regulate Spermatogenesis in Mouse .
9139699	1	CCR-1	160,165	macrophage_inflammatory_protein-1alpha	110,148	CCR-1	macrophage inflammatory protein-1alpha	12768(Tax:10090)	20302(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Comparison to three other related macrophage_inflammatory_protein-1alpha receptors , CCR-1 , CCR-3 , and CCR-5 .
10197373	0	CCR-5	22,27	CD4	42,45	CCR-5	CD4	1234	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Acute upregulation of CCR-5 expression by CD4 + T lymphocytes in HIV-infected patients treated with interleukin-2 .
11563633	0	CCR-5	14,19	CXCR-4	20,26	CCR-5	CXCR-4	1234	7852	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of CCR-5 / CXCR-4 in spinal cord of patients with AIDS .
19183043	0	CCR1	53,57	C-C_chemokine_receptor_1	27,51	CCR1	C-C chemokine receptor 1	57301(Tax:10116)	57301(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Novel pyrrolidine ureas as C-C_chemokine_receptor_1 -LRB- CCR1 -RRB- antagonists .
15927850	0	CCR1	39,43	CCL23	19,24	CCR1	CCL23	1230	6368	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Human CC chemokine CCL23 , a ligand for CCR1 , induces endothelial cell migration and promotes angiogenesis .
21850025	0	CCR1	83,87	CCR10	89,94	CCR1	CCR10	1230	2826	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
21850025	0	CCR1	83,87	CXCR1	96,101	CCR1	CXCR1	1230	3577	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
21850025	0	CCR1	83,87	CXCR2	103,108	CCR1	CXCR2	1230	3579	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
11145699	0	CCR1	62,66	Granulocyte-macrophage_colony_stimulating_factor	0,48	CCR1	Granulocyte-macrophage colony stimulating factor	1230	1437	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Granulocyte-macrophage_colony_stimulating_factor up-regulates CCR1 in human neutrophils .
12711332	0	CCR1	46,50	IL-10	0,5	CCR1	IL-10	1230	3586	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-10 synergistically enhances GM-CSF-induced CCR1 expression in myelomonocytic cells .
15001559	0	CCR1	20,24	LZIP	6,10	CCR1	LZIP	1230	10488	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines .
15730850	0	CCR1	25,29	MIP-1alpha	0,10	CCR1	MIP-1alpha	1230	1230	Gene	Gene	utilizes|dobj|START_ENTITY utilizes|nsubj|END_ENTITY	MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells .
9115216	0	CCR1	44,48	Monocyte_chemotactic_protein-2	0,30	CCR1	Monocyte chemotactic protein-2	1230	6355	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Monocyte_chemotactic_protein-2 -LRB- MCP-2 -RRB- uses CCR1 and CCR2B as its functional receptors .
16355273	0	CCR1	0,4	NFAT2	24,29	CCR1	NFAT2	12768(Tax:10090)	18018(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration .
20053385	0	CCR1	90,94	RANKL	109,114	CCR1	RANKL	12768(Tax:10090)	21943(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Evidences of the cooperative role of the chemokines CCL3 , CCL4 and CCL5 and its receptors CCR1 + and CCR5 + in RANKL + cell migration throughout experimental periodontitis in mice .
15831559	0	CCR1	31,35	TNF-alpha	124,133	CCR1	TNF-alpha	12768(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY acting|nmod|receptor -RSB-|acl|acting mediates|nsubj|-RSB- mediates|nmod|inflammation inflammation|nmod|release release|nmod|END_ENTITY	MIP-1alpha -LSB- CCL3 -RSB- acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4 .
19592420	0	CCR1	0,4	TNF-alpha	79,88	CCR1	TNF-alpha	12768(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha , TGFbeta-1 and IL-6 .
16461304	0	CCR1	45,49	chemokine_receptor	25,43	CCR1	chemokine receptor	1230	7852	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical significance of chemokine_receptor -LRB- CCR1 , CCR2 and CXCR4 -RRB- expression in human myeloma cells : the association with disease activity and survival .
16460738	0	CCR10	32,37	Annexin_A1	52,62	CCR10	Annexin A1	2826	301	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	In vitro and in vivo studies on CCR10 regulation by Annexin_A1 .
21850025	0	CCR10	89,94	CCR1	83,87	CCR10	CCR1	2826	1230	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
21850025	0	CCR10	89,94	CXCR1	96,101	CCR10	CXCR1	2826	3577	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
21850025	0	CCR10	89,94	CXCR2	103,108	CCR10	CXCR2	2826	3579	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
25604634	0	CCR2	71,75	C-C_chemokine_receptor_2	45,69	CCR2	C-C chemokine receptor 2	729230	729230	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The +190 _ G/A -LRB- rs1799864 -RRB- polymorphism in the C-C_chemokine_receptor_2 -LRB- CCR2 -RRB- gene is associated with susceptibility to multiple_sclerosis in HLA-DRB1 * 15:01 - negative individuals .
25746456	0	CCR2	31,35	C-C_chemokine_receptor_type_2	0,29	CCR2	C-C chemokine receptor type 2	12772(Tax:10090)	12772(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	C-C_chemokine_receptor_type_2 -LRB- CCR2 -RRB- signaling protects neonatal male mice with hypoxic-ischemic hippocampal_damage from developing spatial_learning_deficits .
15927208	0	CCR2	0,4	CCL2	126,130	CCR2	CCL2	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY critical|nsubj|expression critical|nmod|END_ENTITY	CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2 .
16150057	0	CCR2	27,31	CCL2	75,79	CCR2	CCL2	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY chemokine|nsubj|expression chemokine|nmod|END_ENTITY	Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1 / CCL2 of GABA-induced currents in spinal cord neurones .
16196033	0	CCR2	36,40	CCL2	154,158	CCR2	CCL2	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|dep|END_ENTITY	Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain : functional effect of MCP-1 / CCL2 on calcium mobilization in primary cultured neurons .
18419759	0	CCR2	60,64	CCL2	7,11	CCR2	CCL2	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	rats|compound|START_ENTITY effective|nmod|rats pronociceptive|ccomp|effective pronociceptive|nsubj|END_ENTITY	Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats .
19535619	0	CCR2	110,114	CCL2	154,158	CCR2	CCL2	729230	6347	Gene	Gene	residue|nmod|START_ENTITY encoding|dobj|residue protein|acl|encoding neutralizes|nsubj|protein neutralizes|dobj|activity activity|nmod|END_ENTITY	A novel recombinant fusion protein encoding a 20-amino_acid residue of the third extracellular -LRB- E3 -RRB- domain of CCR2 neutralizes the biological activity of CCL2 .
20670605	0	CCR2	53,57	CCL2	89,93	CCR2	CCL2	729230	6347	Gene	Gene	expression|nmod|START_ENTITY differ|nmod|expression differ|nmod|END_ENTITY	Porcine monocyte subsets differ in the expression of CCR2 and in their responsiveness to CCL2 .
22177985	0	CCR2	99,103	CCL2	24,28	CCR2	CCL2	12772(Tax:10090)	6347	Gene	Gene	fibroblasts|nmod|START_ENTITY mediates|nmod|fibroblasts mediates|nsubj|analogue analogue|nmod|END_ENTITY	A truncated analogue of CCL2 mediates anti-fibrotic effects on murine fibroblasts independently of CCR2 .
22226505	0	CCR2	16,20	CCL2	0,4	CCR2	CCL2	729230	6347	Gene	Gene	independent|advmod|START_ENTITY independent|nsubj|binding binding|compound|END_ENTITY	CCL2 binding is CCR2 independent in primary adult human astrocytes .
22615942	0	CCR2	0,4	CCL2	27,31	CCR2	CCL2	729230	6347	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|scavenger scavenger|nmod|END_ENTITY	CCR2 acts as scavenger for CCL2 during monocyte chemotaxis .
24583146	0	CCR2	74,78	CCL2	0,4	CCR2	CCL2	729230	6347	Gene	Gene	fibroblasts|nmod|START_ENTITY mediates|nmod|fibroblasts mediates|nsubj|END_ENTITY	CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2 .
26355725	0	CCR2	61,65	CCL2	55,59	CCR2	CCL2	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	FGF2|appos|START_ENTITY FGF2|compound|END_ENTITY	Prophylactic Subacute Administration of Zinc Increases CCL2 , CCR2 , FGF2 , and IGF-1 Expression and Prevents the Long-Term Memory_Loss in a Rat Model of Cerebral_Hypoxia-Ischemia .
26648448	0	CCR2	73,77	CCL2	122,126	CCR2	CCL2	729230	6347	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nmod|cells cells|acl|promoting promoting|dobj|END_ENTITY	N __ - methyl __ - N __ - nitro __ - N ' __ - nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2 - mediated migration .
26839895	0	CCR2	107,111	CCL2	0,4	CCR2	CCL2	729230	6347	Gene	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518 A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance .
26839895	0	CCR2	107,111	CCL2	89,93	CCR2	CCL2	729230	6347	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	CCL2 Serum Levels and Adiposity Are Associated with the Polymorphic Phenotypes -2518 A on CCL2 and 64ILE on CCR2 in a Mexican Population with Insulin Resistance .
10967026	0	CCR2	45,49	CCR5	111,115	CCR2	CCR5	729230	1234	Gene	Gene	gene|compound|START_ENTITY polymorphisms|nmod|gene Influence|nmod|polymorphisms surface|nsubj|Influence surface|dobj|END_ENTITY	Influence of nucleotide polymorphisms in the CCR2 gene and the CCR5 promoter on the expression of cell surface CCR5 and CXCR4 .
12807425	0	CCR2	160,164	CCR5	23,27	CCR2	CCR5	12772(Tax:10090)	12774(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY evidence|nmod|effect mediator|dep|evidence mediator|nsubj|END_ENTITY	The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic_acid-induced hippocampal_injury : evidence for a compensatory effect by increased CCR2 and CCR3 .
14685276	0	CCR2	80,84	CCR5	29,33	CCR2	CCR5	729230	1234	Gene	Gene	receptor|compound|START_ENTITY trans|nmod|receptor acting|nmod|trans HIV-1_infection|acl|acting HIV-1_infection|nmod|receptors receptors|compound|END_ENTITY	Blocking HIV-1_infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor .
16055130	0	CCR2	46,50	CCR5	60,64	CCR2	CCR5	729230	1234	Gene	Gene	CC-chemokine_receptor-2|appos|START_ENTITY CC-chemokine_receptor-2|appos|END_ENTITY	Polymorphisms in the CC-chemokine_receptor-2 -LRB- CCR2 -RRB- and -5 -LRB- CCR5 -RRB- genes and risk of coronary_heart_disease among US women .
16596402	0	CCR2	125,129	CCR5	40,44	CCR2	CCR5	100358097(Tax:9986)	100101579(Tax:9986)	Gene	Gene	conversion|nmod|START_ENTITY domain|nmod|conversion alteration|nmod|domain variation|dep|alteration variation|nmod|END_ENTITY	Genetic variation at chemokine receptor CCR5 in leporids : alteration at the 2nd extracellular domain by gene conversion with CCR2 in Oryctolagus , but not in Sylvilagus and Lepus species .
21454357	0	CCR2	25,29	CCR5	30,34	CD16	CCR5	2214	1234	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Paradoxical role of CD16 + CCR2 + CCR5 + monocytes in tuberculosis : efficient APC in pleural_effusion but also mark disease severity in blood .
22285384	0	CCR2	46,50	CCR5	60,64	CCR2	CCR5	729230	1234	Gene	Gene	CC-chemokine_receptor-2|appos|START_ENTITY CC-chemokine_receptor-2|appos|END_ENTITY	Polymorphisms in the CC-chemokine_receptor-2 -LRB- CCR2 -RRB- and -5 -LRB- CCR5 -RRB- genes and risk of myocardial_infarction among Tunisian male patients .
23426986	0	CCR2	42,46	CCR5	102,106	CCR2	CCR5	729230	1234	Gene	Gene	detection|nmod|START_ENTITY improves|dobj|detection improves|nmod|monocytes monocytes|acl:relcl|evaluating evaluating|dobj|END_ENTITY	Sequential staining improves detection of CCR2 and CX3CR1 on monocytes when simultaneously evaluating CCR5 by multicolor flow cytometry .
18722120	0	CCR2	97,101	CC_chemokine_receptor_2	72,95	CCR2	CC chemokine receptor 2	729230	729230	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and evaluation of cis-3 ,4 - disubstituted_piperidines as potent CC_chemokine_receptor_2 -LRB- CCR2 -RRB- antagonists .
19481449	0	CCR2	96,100	CC_chemokine_receptor_2	71,94	CCR2	CC chemokine receptor 2	729230	729230	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Novel sulfone-containing di - _ and_trisubstituted_cyclohexanes as potent CC_chemokine_receptor_2 -LRB- CCR2 -RRB- antagonists .
21247529	0	CCR2	34,38	CC_chemokine_receptor_2	10,33	CCR2	CC chemokine receptor 2	729230	729230	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CC_chemokine_receptor_2 CCR2 blockade on serum C-reactive_protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte_chemoattractant_protein-1 promoter region .
15172112	0	CCR2	15,19	CD14	10,14	CCR2	CD14	729230	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased CD14 + CCR2 + monocytes in active multiple_sclerosis .
25340088	0	CCR2	0,4	CD14	8,12	CCR2	CD14	729230	929	Gene	Gene	START_ENTITY|nmod|monocytes monocytes|amod|END_ENTITY	CCR2 on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is a biomarker of HIV-associated_neurocognitive_disorders .
21454357	0	CCR2	25,29	CD16	20,24	CD16	CD16	2214	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Paradoxical role of CD16 + CCR2 + CCR5 + monocytes in tuberculosis : efficient APC in pleural_effusion but also mark disease severity in blood .
25340088	0	CCR2	0,4	CD16	15,19	CCR2	CD16	729230	2214	Gene	Gene	START_ENTITY|nmod|monocytes monocytes|amod|END_ENTITY	CCR2 on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is a biomarker of HIV-associated_neurocognitive_disorders .
12775413	0	CCR2	14,18	CD4	39,42	CCR2	CD4	729230	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|cells cells|compound|END_ENTITY	Expression of CCR2 , CCR5 , and CXCR3 by CD4 + T cells is stable during a 2-year longitudinal study but varies widely between individuals .
15361701	0	CCR2	15,19	CD68	0,4	CCR2	CD68	729230	968	Gene	Gene	expression|nummod|START_ENTITY reflect|nsubj|expression END_ENTITY|parataxis|reflect	CD68 and MCP-1 / CCR2 expression of initial biopsies reflect the outcomes of membranous_nephropathy .
23110041	0	CCR2	27,31	CD68	21,25	CCR2	CD68	12772(Tax:10090)	12514(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enrichment of murine CD68 + CCR2 + and CD68 + CD206 + lung macrophages in acute pancreatitis-associated acute_lung_injury .
16320328	0	CCR2	19,23	Chemokine_receptor	0,18	CCR2	Chemokine receptor	729230	7852	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Chemokine_receptor CCR2 expression by systemic_sclerosis fibroblasts : evidence for autocrine regulation of myofibroblast differentiation .
12689946	0	CCR2	38,42	Eotaxin-3	0,9	CCR2	Eotaxin-3	729230	10344	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes .
24778447	0	CCR2	39,43	FPR1	97,101	CCR2	FPR1	729230	2357	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Cross-desensitization of CCR1 , but not CCR2 , following activation of the formyl peptide receptor FPR1 .
19841162	0	CCR2	32,36	FROUNT	0,6	CCR2	FROUNT	729230	79902	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	FROUNT is a common regulator of CCR2 and CCR5 signaling to control directional migration .
21193048	0	CCR2	77,81	FROUNT	37,43	CCR2	FROUNT	729230	79902	Gene	Gene	regulator|nmod|START_ENTITY Expression|appos|regulator Expression|nmod|END_ENTITY	Expression and purification of human FROUNT , a common cytosolic regulator of CCR2 and CCR5 .
24128342	0	CCR2	139,143	FROUNT	66,72	CCR2	FROUNT	729230	79902	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5 .
25283965	0	CCR2	98,102	FROUNT	132,138	CCR2	FROUNT	729230	79902	Gene	Gene	basis|nmod|START_ENTITY END_ENTITY|nsubj|basis	Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT .
19196047	0	CCR2	56,60	IL-10	10,15	CCR2	IL-10	729230	3586	Gene	Gene	Cytokine|dep|START_ENTITY Cytokine|dep|END_ENTITY	Cytokine -LRB- IL-10 -1082 and -819 -RRB- and chemokine_receptor -LRB- CCR2 and CCR5 -RRB- gene polymorphism in North Indian patients with end-stage_renal_disease .
10419877	0	CCR2	8,12	MCP-1	152,157	CCR2	MCP-1	729230	6347	Gene	Gene	expression|compound|START_ENTITY Loss|nmod|expression Loss|dep|role role|nmod|END_ENTITY	Loss of CCR2 expression and functional response to monocyte_chemotactic_protein -LRB- MCP-1 -RRB- during the differentiation of human monocytes : role of secreted MCP-1 in the regulation of the chemotactic response .
10419877	0	CCR2	8,12	MCP-1	81,86	CCR2	MCP-1	729230	6347	Gene	Gene	expression|compound|START_ENTITY expression|nmod|monocyte_chemotactic_protein monocyte_chemotactic_protein|appos|END_ENTITY	Loss of CCR2 expression and functional response to monocyte_chemotactic_protein -LRB- MCP-1 -RRB- during the differentiation of human monocytes : role of secreted MCP-1 in the regulation of the chemotactic response .
10479649	0	CCR2	14,18	MCP-1	59,64	CCR2	MCP-1	729230	6347	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|implications implications|nmod|END_ENTITY	Expression of CCR2 by endothelial cells : implications for MCP-1 mediated wound_injury repair and In vivo inflammatory activation of endothelium .
10710532	0	CCR2	25,29	MCP-1	0,5	CCR2	MCP-1	729230	6347	Gene	Gene	haptotaxis|nummod|START_ENTITY END_ENTITY|dep|haptotaxis	MCP-1 in pleural_injury : CCR2 mediates haptotaxis of pleural mesothelial cells .
11518728	0	CCR2	38,42	MCP-1	32,37	CCR2	MCP-1	12772(Tax:10090)	17224(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Critical role for the chemokine MCP-1 / CCR2 in the pathogenesis of bronchiolitis_obliterans_syndrome .
12078856	0	CCR2	66,70	MCP-1	13,18	CCR2	MCP-1	729230	6347	Gene	Gene	receptor|nummod|START_ENTITY role|nmod|receptor Induction|dep|role Induction|nmod|expression expression|compound|END_ENTITY	Induction of MCP-1 expression in airway epithelial cells : role of CCR2 receptor in airway epithelial injury .
15629146	0	CCR2	29,33	MCP-1	116,121	CCR2	MCP-1	729230	6347	Gene	Gene	mutagenesis|nmod|START_ENTITY identified|nsubj|mutagenesis identified|advcl|transmembrane transmembrane|xcomp|important important|nmod|binding binding|compound|END_ENTITY	Site-directed mutagenesis of CCR2 identified amino_acid residues in transmembrane helices 1 , 2 , and 7 important for MCP-1 binding and biological functions .
16095529	0	CCR2	17,21	MCP-1	11,16	CCR2	MCP-1	729230	6347	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for MCP-1 / CCR2 in interstitial_lung_disease in children .
16150057	0	CCR2	27,31	MCP-1	69,74	CCR2	MCP-1	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY chemokine|nsubj|expression chemokine|nmod|CCL2 CCL2|compound|END_ENTITY	Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1 / CCL2 of GABA-induced currents in spinal cord neurones .
16196033	0	CCR2	36,40	MCP-1	148,153	CCR2	MCP-1	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|dep|effect effect|nmod|END_ENTITY	Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain : functional effect of MCP-1 / CCL2 on calcium mobilization in primary cultured neurons .
16518346	0	CCR2	10,14	MCP-1	4,9	CCR2	MCP-1	729230	6347	Gene	Gene	system|compound|START_ENTITY has|nsubj|system END_ENTITY|parataxis|has	The MCP-1 / CCR2 system has direct proinflammatory effects in human mesangial cells .
16857270	0	CCR2	25,29	MCP-1	0,5	CCR2	MCP-1	729230	6347	Gene	Gene	START_ENTITY|amod|chemokine chemokine|amod|END_ENTITY	MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic_lateral_sclerosis -LRB- sALS -RRB- .
17222215	0	CCR2	6,10	MCP-1	0,5	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulates|nsubj|pathway END_ENTITY|appos|regulates	MCP-1 / CCR2 signalling pathway regulates hyperoxia-induced acute_lung_injury via nitric_oxide production .
17631861	0	CCR2	20,24	MCP-1	14,19	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	ameliorates|nsubj|START_ENTITY Inhibition|parataxis|ameliorates Inhibition|nmod|END_ENTITY	Inhibition of MCP-1 / CCR2 pathway ameliorates the development of diabetic_nephropathy .
18463419	0	CCR2	20,24	MCP-1	14,19	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY inhibit|nsubj|signaling Inhibition|parataxis|inhibit Inhibition|nmod|END_ENTITY	Inhibition of MCP-1 / CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model .
18579703	0	CCR2	6,10	MCP-1	0,5	CCR2	MCP-1	729230	6347	Gene	Gene	system|compound|START_ENTITY involved|nsubjpass|system END_ENTITY|appos|involved	MCP-1 / CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells .
19002595	0	CCR2	20,24	MCP-1	14,19	CCR2	MCP-1	729230	6347	Gene	Gene	axis|compound|START_ENTITY promotes|nsubj|axis Activation|parataxis|promotes Activation|nmod|END_ENTITY	Activation of MCP-1 / CCR2 axis promotes prostate_cancer growth in bone .
19942750	0	CCR2	0,4	MCP-1	6,11	CCR2	MCP-1	729230	6347	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|dep|END_ENTITY	CCR2 , MCP-1 , SDF-1a _ DC-SIGN gene polymorphisms in HIV-1 infected patients with _ without tuberculosis .
20180766	0	CCR2	20,24	MCP-1	14,19	CCR2	MCP-1	729230	6347	Gene	Gene	System|compound|START_ENTITY System|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the MCP-1 / CCR2 System in diabetic_kidney_disease .
21589925	0	CCR2	137,141	MCP-1	0,5	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	MCP-1 upregulates amylin expression in murine pancreatic b cells through ERK/JNK-AP 1 and NF-kB related signaling pathways independent of CCR2 .
22006533	0	CCR2	10,14	MCP-1	4,9	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	axis|nummod|START_ENTITY involved|nsubjpass|axis END_ENTITY|parataxis|involved	The MCP-1 / CCR2 axis in podocytes is involved in apoptosis induced by diabetic_conditions .
22740067	0	CCR2	6,10	MCP-1	0,5	CCR2	MCP-1	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	interactions|nsubj|START_ENTITY END_ENTITY|appos|interactions	MCP-1 / CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes .
23007133	0	CCR2	47,51	MCP-1	40,45	CCR2	MCP-1	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	system|compound|START_ENTITY system|amod|monocyte_chemoattractant_protein-1 monocyte_chemoattractant_protein-1|dep|END_ENTITY	The monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- / CCR2 system is involved in peritoneal_dialysis-related epithelial-mesenchymal transition of peritoneal mesothelial cells .
23107893	0	CCR2	20,24	MCP-1	14,19	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY involved|nsubjpass|signaling Inhibition|parataxis|involved Inhibition|nmod|END_ENTITY	Inhibition of MCP-1 / CCR2 signaling pathway is involved in synergistic inhibitory effects of irbesartan with rosuvastatin on vascular remodeling .
23408426	0	CCR2	41,45	MCP-1	159,164	CCR2	MCP-1	729230	6347	Gene	Gene	sulfation|nmod|START_ENTITY enhances|nsubj|sulfation enhances|nmod|forms forms|nmod|monocyte_chemoattractant_protein-1 monocyte_chemoattractant_protein-1|appos|END_ENTITY	Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- .
24252211	0	CCR2	6,10	MCP-1	0,5	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	astrocytosis|nummod|START_ENTITY accelerated|nsubjpass|astrocytosis END_ENTITY|appos|accelerated	MCP-1 / CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS .
24416305	0	CCR2	48,52	MCP-1	42,47	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Monocytes infiltrate the pancreas via the MCP-1 / CCR2 pathway and differentiate into stellate cells .
25970072	0	CCR2	31,35	MCP-1	25,30	CCR2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	Spiegelmer-Inhibition|dep|START_ENTITY Spiegelmer-Inhibition|nmod|END_ENTITY	Spiegelmer-Inhibition of MCP-1 / CCR2 - potential as an adjunct immunosuppressive therapy in transplantation .
26733169	0	CCR2	100,104	MCP-1	94,99	CCR2	MCP-1	729230	6347	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Human umbilical cord mesenchymal stem cells delivering sTRAIL home to lung_cancer mediated by MCP-1 / CCR2 axis and exhibit antitumor effects .
26302185	0	CCR2	127,131	MCP-3	121,126	CCR2	MCP-3	12772(Tax:10090)	20306(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Tissue_factor_pathway_inhibitor gene transfer prevents vascular smooth muscle cell proliferation by interfering with the MCP-3 / CCR2 pathway .
22904274	0	CCR2	35,39	Monocyte_chemoattractant_protein-1	0,34	CCR2	Monocyte chemoattractant protein-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY promotes|nsubj|axis END_ENTITY|parataxis|promotes	Monocyte_chemoattractant_protein-1 / CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations .
16306213	0	CCR2	19,23	THP-1	48,53	CCR2	THP-1	729230	2736	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of MCP1 , CCR2 , and iNOS expression in THP-1 macrophages by serum of children late after Kawasaki_disease .
17522124	0	CCR2	44,48	VEGF	25,29	CCR2	VEGF	12772(Tax:10090)	22339(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Delayed angiogenesis and VEGF production in CCR2 - / - mice during impaired skeletal muscle regeneration .
21589925	0	CCR2	137,141	amylin	18,24	CCR2	amylin	12772(Tax:10090)	15874(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	MCP-1 upregulates amylin expression in murine pancreatic b cells through ERK/JNK-AP 1 and NF-kB related signaling pathways independent of CCR2 .
10477627	0	CCR2	17,21	chemokine_receptor	22,40	CCR2	chemokine receptor	729230	7852	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Up-regulation of CCR2 chemokine_receptor expression and increased susceptibility to the multitropic HIV_strain 89.6 in monocytes exposed to glucocorticoid hormones .
16461304	0	CCR2	51,55	chemokine_receptor	25,43	CCR2	chemokine receptor	729230	7852	Gene	Gene	CCR1|dep|START_ENTITY expression|appos|CCR1 expression|amod|END_ENTITY	Clinical significance of chemokine_receptor -LRB- CCR1 , CCR2 and CXCR4 -RRB- expression in human myeloma cells : the association with disease activity and survival .
19913021	0	CCR2	109,113	chemokine_receptor	14,32	CCR2	chemokine receptor	574098(Tax:9544)	574188(Tax:9544)	Gene	Gene	antagonist|compound|START_ENTITY evaluations|nmod|antagonist function|nmod|evaluations function|nsubj|Assessment Assessment|nmod|END_ENTITY	Assessment of chemokine_receptor function on monocytes in whole blood : In vitro and ex vivo evaluations of a CCR2 antagonist .
9365120	0	CCR2	14,18	chemokine_receptor	19,37	CCR2	chemokine receptor	729230	7852	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of CCR2 chemokine_receptor mRNA stability .
11717355	0	CCR2	23,27	monocyte_chemoattractant_protein-1	72,106	CCR2	monocyte chemoattractant protein-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|binding binding|nmod|microvessels microvessels|amod|END_ENTITY	The chemokine receptor CCR2 mediates the binding and internalization of monocyte_chemoattractant_protein-1 along brain microvessels .
14662900	0	CCR2	48,52	monocyte_chemoattractant_protein-1	13,47	CCR2	monocyte chemoattractant protein-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Blocking the monocyte_chemoattractant_protein-1 / CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed_death-1 ligand-1-dependent mechanism .
15059935	0	CCR2	61,65	monocyte_chemoattractant_protein-1	17,51	CCR2	monocyte chemoattractant protein-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|receptor receptor|amod|END_ENTITY	Critical role of monocyte_chemoattractant_protein-1 receptor CCR2 on monocytes in hypertension-induced vascular_inflammation and remodeling .
19420107	0	CCR2	39,43	monocyte_chemoattractant_protein-1	4,38	CCR2	monocyte chemoattractant protein-1	729230	6347	Gene	Gene	loop|compound|START_ENTITY loop|amod|END_ENTITY	The monocyte_chemoattractant_protein-1 / CCR2 loop , inducible by TGF-beta , increases podocyte motility and albumin permeability .
23007133	0	CCR2	47,51	monocyte_chemoattractant_protein-1	4,38	CCR2	monocyte chemoattractant protein-1	60463(Tax:10116)	24770(Tax:10116)	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	The monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- / CCR2 system is involved in peritoneal_dialysis-related epithelial-mesenchymal transition of peritoneal mesothelial cells .
23408426	0	CCR2	41,45	monocyte_chemoattractant_protein-1	123,157	CCR2	monocyte chemoattractant protein-1	729230	6347	Gene	Gene	sulfation|nmod|START_ENTITY enhances|nsubj|sulfation enhances|nmod|forms forms|nmod|END_ENTITY	Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- .
26591766	0	CCR2	77,81	monocyte_chemoattractant_protein-1_receptor	33,76	CCR2	monocyte chemoattractant protein-1 receptor	729230	729230	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	-LSB- Interaction of polymorphisms of monocyte_chemoattractant_protein-1_receptor CCR2 gene 190A/G , nicotinamide_adenine_dinucleotide_phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic_fatty_liver_disease -RSB- .
10419877	0	CCR2	8,12	monocyte_chemotactic_protein	51,79	CCR2	monocyte chemotactic protein	729230	6347	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Loss of CCR2 expression and functional response to monocyte_chemotactic_protein -LRB- MCP-1 -RRB- during the differentiation of human monocytes : role of secreted MCP-1 in the regulation of the chemotactic response .
10428302	0	CCR2	58,62	tumor_necrosis_factor-alpha	18,45	CCR2	tumor necrosis factor-alpha	729230	7124	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Downregulation by tumor_necrosis_factor-alpha of monocyte CCR2 expression and monocyte_chemotactic_protein-1-induced transendothelial migration is antagonized by oxidized low-density lipoprotein : a potential mechanism of monocyte retention in atherosclerotic_lesions .
11358512	0	CCR2	0,4	vMIP-II	59,66	CCR2	vMIP-II	729230	4961514(Tax:37296)	Gene	Gene	properties|nummod|START_ENTITY properties|nmod|END_ENTITY	CCR2 and CCR5 receptor-binding properties of herpesvirus-8 vMIP-II based on sequence analysis and its solution structure .
20808917	0	CCR2B	19,24	Filamin_a	0,9	CCR2B	Filamin a	729230	2316	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Filamin_a binds to CCR2B and regulates its internalization .
9837883	0	CCR2B	92,97	monocyte_chemoattractant_protein-1	10,44	CCR2B	monocyte chemoattractant protein-1	729230	6347	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Monomeric monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- binds and activates the MCP-1_receptor CCR2B .
11306977	0	CCR3	31,35	CCR3	70,74	CCR3	CCR3	1232	1232	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Aminooxypentane-RANTES induces CCR3 activation and internalization of CCR3 from the surface of human eosinophils .
11306977	0	CCR3	70,74	CCR3	31,35	CCR3	CCR3	1232	1232	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Aminooxypentane-RANTES induces CCR3 activation and internalization of CCR3 from the surface of human eosinophils .
23977659	0	CCR3	0,4	CCR4	6,10	CCR3	CCR4	1232	1233	Gene	Gene	CCR5|compound|START_ENTITY CCR5|appos|END_ENTITY	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
15664858	0	CCR3	67,71	CC_chemokine_receptor-3	42,65	CCR3	CC chemokine receptor-3	1232	1232	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	N-Arylalkylpiperidine_urea derivatives as CC_chemokine_receptor-3 -LRB- CCR3 -RRB- antagonists .
15771462	0	CCR3	38,42	CC_chemokine_receptor-3	13,36	CCR3	CC chemokine receptor-3	12771(Tax:10090)	12771(Tax:10090)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of CC_chemokine_receptor-3 -LRB- CCR3 -RRB- antagonists with picomolar potency .
16931001	0	CCR3	68,72	CC_chemokine_receptor_3	43,66	CCR3	CC chemokine receptor 3	1232	1232	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	2,4-Disubstituted _ piperidines as selective CC_chemokine_receptor_3 -LRB- CCR3 -RRB- antagonists : synthesis and selectivity .
10226056	0	CCR3	96,100	CD4	0,3	CCR3	CD4	1232	920	Gene	Gene	receptor-dependent|dep|START_ENTITY receptor-dependent|nsubj|END_ENTITY	CD4 receptor-dependent entry of human_immunodeficiency_virus_type-1 env-pseudotypes into CCR5 - , CCR3 - , and CXCR4-expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor .
11369641	0	CCR3	162,166	CD4	130,133	CCR3	CD4	1232	920	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|cells/basophils cells/basophils|nmod|blood blood|acl:relcl|susceptible susceptible|nmod|expression expression|nmod|END_ENTITY	Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3 , CCR5 , and CXCR4 .
15379987	0	CCR3	20,24	CD4	15,18	CCR3	CD4	1232	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CCR5 + and CD4 + CCR3 + lymphocyte subset and monocyte apoptosis in patients with acute visceral_leishmaniasis .
19302742	0	CCR3	55,59	CD4	79,82	CCR3	CD4	12771(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptors|dep|START_ENTITY receptors|nmod|T T|compound|END_ENTITY	Relationship between expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells and spontaneous_abortion in mice .
19781371	0	CCR3	34,38	CD4	58,61	CCR3	CD4	12771(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptors|dep|START_ENTITY receptors|nmod|T T|compound|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
20659406	0	CCR3	20,24	CD4	28,31	CCR3	CD4	1232	920	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Decreased levels of CCR3 in CD4 + lymphocytes of rheumatoid_arthritis patients .
23977659	0	CCR3	0,4	CD4	59,62	CCR3	CD4	1232	920	Gene	Gene	CCR5|compound|START_ENTITY CCR5|nmod|+ +|compound|END_ENTITY	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
11120849	0	CCR3	96,100	Fc_epsilon_RI	121,134	CCR3	Fc epsilon RI	1232	2205	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Tat protein is an HIV-1-encoded beta-chemokine homolog that promotes migration and up-regulates CCR3 expression on human Fc_epsilon_RI + cells .
21041734	0	CCR3	30,34	GATA-1	20,26	CCR3	GATA-1	1232	2623	Gene	Gene	transcription|compound|START_ENTITY END_ENTITY|nmod|transcription	The crucial role of GATA-1 in CCR3 gene transcription : modulated balance by multiple GATA elements in the CCR3 regulatory region .
10201960	0	CCR3	80,84	IL-2	88,92	CCR3	IL-2	1232	3558	Gene	Gene	express|dobj|START_ENTITY express|nmod|END_ENTITY	Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 .
10201960	0	CCR3	80,84	IL-4	107,111	CCR3	IL-4	1232	3565	Gene	Gene	express|dobj|START_ENTITY express|nmod|END_ENTITY	Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 .
11160286	0	CCR3	77,81	IL-4	96,100	CCR3	IL-4	1232	3565	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	T cell phenotypes of the normal nasal mucosa : induction of Th2 cytokines and CCR3 expression by IL-4 .
19038554	0	CCR3	34,38	IL-4	53,57	CCR3	IL-4	1232	3565	Gene	Gene	silencing|nmod|START_ENTITY downregulates|nsubj|silencing downregulates|dobj|END_ENTITY	Post-transcriptional silencing of CCR3 downregulates IL-4 stimulated release of eotaxin-3 -LRB- CCL26 -RRB- and other CCR3 ligands in alveolar type II cells .
19781371	0	CCR3	34,38	IL-4	124,128	CCR3	IL-4	12771(Tax:10090)	16189(Tax:10090)	Gene	Gene	receptors|dep|START_ENTITY cells|amod|receptors Expression|nmod|cells Expression|acl|induced induced|nmod|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
15219825	0	CCR3	51,55	epidermal_growth_factor_receptor	14,46	CCR3	epidermal growth factor receptor	1232	1956	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of epidermal_growth_factor_receptor via CCR3 in bronchial epithelial cells .
23409871	0	CCR4	115,119	CC-chemokine_receptor_4	90,113	CCR4	CC-chemokine receptor 4	1233	1233	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and structure-activity relationships of indazole_arylsulfonamides as allosteric CC-chemokine_receptor_4 -LRB- CCR4 -RRB- antagonists .
24515101	0	CCR4	135,139	CC-chemokine_receptor_4	110,133	CCR4	CC-chemokine receptor 4	1233	1233	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Lead identification and structure-activity relationships of heteroarylpyrazole_arylsulfonamides as allosteric CC-chemokine_receptor_4 -LRB- CCR4 -RRB- antagonists .
24909677	0	CCR4	107,111	CC-chemokine_receptor_4	82,105	CCR4	CC-chemokine receptor 4	1233	1233	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Lead identification of benzimidazolone and azabenzimidazolone_arylsulfonamides as CC-chemokine_receptor_4 -LRB- CCR4 -RRB- antagonists .
14971049	0	CCR4	65,69	CCL17	24,29	CCR4	CCL17	1233	6361	Gene	Gene	Dominance|nmod|START_ENTITY Dominance|nmod|END_ENTITY	Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells .
15466387	0	CCR4	8,12	CCL17	22,27	CCR4	CCL17	12773(Tax:10090)	20295(Tax:10090)	Gene	Gene	ligands|nummod|START_ENTITY ligands|appos|END_ENTITY	Role of CCR4 ligands , CCL17 and CCL22 , during Schistosoma_mansoni egg-induced pulmonary_granuloma formation in mice .
15955100	0	CCR4	31,35	CCL17	94,99	CCR4	CCL17	1233	6361	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of the chemokine receptor CCR4 and its ligand thymus - _ and_activation-regulated_chemokine / CCL17 for lymphocyte recruitment in cutaneous_lupus_erythematosus .
18052724	0	CCR4	33,37	CCL17	55,60	CCR4	CCL17	12773(Tax:10090)	20295(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of chemokine receptor CCR4 and its ligands -LRB- CCL17 and CCL22 -RRB- in murine contact_hypersensitivity .
19630858	0	CCR4	12,16	CCL17	87,92	CCR4	CCL17	1233	6361	Gene	Gene	Blockade|nmod|START_ENTITY reveals|nsubj|Blockade reveals|dobj|role role|nmod|END_ENTITY	Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway_inflammation .
22335621	0	CCR4	190,194	CCL17	155,160	CCR4	CCL17	1233	6361	Gene	Gene	determine|nmod|START_ENTITY determine|dobj|efficacy efficacy|nmod|END_ENTITY	Development of operational models of receptor activation including constitutive receptor activity and their use to determine the efficacy of the chemokine CCL17 at the CC chemokine receptor CCR4 .
24339934	0	CCR4	86,90	CCL17	46,51	CCR4	CCL17	1233	6361	Gene	Gene	signaling|nmod|START_ENTITY required|advcl|signaling required|nsubjpass|Engagement Engagement|nmod|domains domains|nmod|END_ENTITY	Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung .
14971049	0	CCR4	65,69	CCL22	13,18	CCR4	CCL22	1233	6367	Gene	Gene	Dominance|nmod|START_ENTITY Dominance|nmod|END_ENTITY	Dominance of CCL22 over CCL17 in induction of chemokine receptor CCR4 desensitization and internalization on human Th2 cells .
18811584	0	CCR4	125,129	CCL27	111,116	CCR4	CCL27	1233	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
23977659	0	CCR4	6,10	CCR3	0,4	CCR4	CCR3	1233	1232	Gene	Gene	CCR5|appos|START_ENTITY CCR5|compound|END_ENTITY	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
18811584	0	CCR4	125,129	CCR5	131,135	CCR4	CCR5	1233	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
20042588	0	CCR4	17,21	CCR6	22,26	CCR4	CCR6	1233	1235	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Peripheral blood CCR4 + CCR6 + and CXCR3 + CCR6 + CD4 + T cells are highly permissive to HIV-1_infection .
21338515	0	CCR4	89,93	CCR6	94,98	CCR4	CCR6	1233	1235	Gene	Gene	imbalance|compound|START_ENTITY imbalance|compound|END_ENTITY	Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4 + CCR6 + Th/Treg cell subset imbalance in ankylosing_spondylitis .
19654865	0	CCR4	52,56	CD25	63,67	CCR4	CD25	1233	3559	Gene	Gene	CD4|compound|START_ENTITY levels|nmod|CD4 +|nsubj|levels +|dobj|cells cells|nummod|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
11174204	0	CCR4	0,4	CD4	12,15	CCR4	CD4	1233	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|nummod|END_ENTITY	CCR4 memory CD4 + T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic_dermatitis .
11359851	0	CCR4	19,23	CD4	27,30	CCR4	CD4	1233	920	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11560999	0	CCR4	83,87	CD4	100,103	CCR4	CD4	1233	920	Gene	Gene	chemokine_receptors|dep|START_ENTITY chemokine_receptors|nmod|CD25 CD25|compound|END_ENTITY	Unique chemotactic response profile and specific expression of chemokine_receptors CCR4 and CCR8 by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells .
12699425	0	CCR4	0,4	CD4	70,73	CCR4	CD4	1233	920	Gene	Gene	chemokine_receptor|nsubj|START_ENTITY chemokine_receptor|nmod|cells cells|compound|END_ENTITY	CCR4 is an up-regulated chemokine_receptor of peripheral blood memory CD4 + T cells in Crohn 's _ disease .
15498047	0	CCR4	10,14	CD4	41,44	CCR4	CD4	1233	920	Gene	Gene	expression|compound|START_ENTITY expression|acl|circulating circulating|dobj|+ +|compound|END_ENTITY	Increased CCR4 expression on circulating CD4 -LRB- + -RRB- T cells in ankylosing_spondylitis , rheumatoid_arthritis and systemic_lupus_erythematosus .
16804321	0	CCR4	80,84	CD4	76,79	CCR4	CD4	1233	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Delayed allergic_reaction to suxamethonium driven by oligoclonal Th1-skewed CD4 + CCR4 + IFN-gamma + memory T cells .
17339428	0	CCR4	33,37	CD4	96,99	CCR4	CD4	12773(Tax:10090)	12504(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|accumulation accumulation|nmod|cells cells|compound|END_ENTITY	Cutting Edge : Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions .
17442093	0	CCR4	42,46	CD4	34,37	CCR4	CD4	1233	920	Gene	Gene	mycosis|nsubj|START_ENTITY mycosis|ccomp|effective effective|nmod|END_ENTITY	Interferon-alpha is effective for CD4 -LRB- + -RRB- , CCR4 -LRB- - -RRB- mycosis fungoides .
19293635	0	CCR4	31,35	CD4	39,42	CCR4	CD4	1233	920	Gene	Gene	addition|nmod|START_ENTITY enhances|nsubj|addition enhances|nsubj|cells cells|amod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
20412707	0	CCR4	27,31	CD4	84,87	CCR4	CD4	1233	920	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|subpopulation subpopulation|nmod|END_ENTITY	Lower numbers of FoxP3 and CCR4 co-expressing cells in an elevated subpopulation of CD4 + CD25high regulatory T cells from Wegener 's _ granulomatosis .
20963786	0	CCR4	113,117	CD4	127,130	CCR4	CD4	1233	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4 + T cells .
22664869	0	CCR4	27,31	CD4	82,85	CCR4	CD4	171054(Tax:10116)	24932(Tax:10116)	Gene	Gene	requirements|nmod|START_ENTITY requirements|nmod|migration migration|nmod|END_ENTITY	Differing requirements for CCR4 , E-selectin , and a4b1 for the migration of memory CD4 and activated T cells to dermal_inflammation .
23977659	0	CCR4	6,10	CD4	59,62	CCR4	CD4	1233	920	Gene	Gene	CCR5|appos|START_ENTITY CCR5|nmod|+ +|compound|END_ENTITY	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
24840326	0	CCR4	70,74	CD4	78,81	CCR4	CD4	403541(Tax:9615)	403931(Tax:9615)	Gene	Gene	lymphocytes|amod|START_ENTITY lymphocytes|compound|END_ENTITY	Preferential gene transcription of T helper 2 cytokines in peripheral CCR4 -LRB- + -RRB- CD4 -LRB- + -RRB- lymphocytes in dogs .
24960164	0	CCR4	39,43	CD4	35,38	CCR4	CD4	1233	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	HTLV-1 induces a Th1-like state in CD4 + CCR4 + T cells .
25650058	0	CCR4	25,29	CD4	71,74	CCR4	CD4	403541(Tax:9615)	403931(Tax:9615)	Gene	Gene	<sup>|compound|START_ENTITY proportions|nmod|<sup> +|nsubj|proportions +|nmod|cells cells|compound|END_ENTITY	Increased proportions of CCR4 <sup> + </sup> cells among peripheral blood CD4 <sup> + </sup> cells and serum levels of allergen-specific IgE antibody in canine chronic rhinitis and bronchitis .
22319577	0	CCR4	16,20	CTLA-4	23,29	CCR4	CTLA-4	1233	1493	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Accumulation of CCR4 CTLA-4 FOXP3 CD25 -LRB- hi -RRB- regulatory T cells in colon_adenocarcinomas correlate to reduced activation of conventional T cells .
18811584	0	CCR4	125,129	CXCR3	137,142	CCR4	CXCR3	1233	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
22319577	0	CCR4	16,20	FOXP3	30,35	CCR4	FOXP3	1233	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Accumulation of CCR4 CTLA-4 FOXP3 CD25 -LRB- hi -RRB- regulatory T cells in colon_adenocarcinomas correlate to reduced activation of conventional T cells .
15809349	0	CCR4	86,90	Foxp3	15,20	CCR4	Foxp3	12773(Tax:10090)	20371(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY depends|nmod|receptor depends|nsubj|Recruitment Recruitment|nmod|cells cells|compound|END_ENTITY	Recruitment of Foxp3 + T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor .
21945175	0	CCR4	0,4	Foxp3	28,33	CCR4	Foxp3	12773(Tax:10090)	20371(Tax:10090)	Gene	Gene	migration|nummod|START_ENTITY migration|nmod|+ +|compound|END_ENTITY	CCR4 dependent migration of Foxp3 + Treg cells to skin grafts and draining lymph nodes is implicated in enhanced graft survival in CD200tg recipients .
18811584	0	CCR4	125,129	IFN-beta	161,169	CCR4	IFN-beta	1233	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
11359851	0	CCR4	19,23	IFN-gamma	134,143	CCR4	IFN-gamma	1233	3458	Gene	Gene	defines|nsubj|START_ENTITY defines|dobj|subset subset|dep|ratios ratios|amod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
16804321	0	CCR4	80,84	IFN-gamma	85,94	CCR4	IFN-gamma	1233	3458	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Delayed allergic_reaction to suxamethonium driven by oligoclonal Th1-skewed CD4 + CCR4 + IFN-gamma + memory T cells .
19654865	0	CCR4	52,56	IFN-gamma	41,50	CCR4	IFN-gamma	1233	3458	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
18811584	0	CCR4	125,129	IP-10	118,123	CCR4	IP-10	1233	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCR4	125,129	MIP-1alpha	99,109	CCR4	MIP-1alpha	1233	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCR4	125,129	PD1	144,147	CCR4	PD1	1233	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCR4	125,129	PDL2	149,153	CCR4	PDL2	1233	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
19293635	0	CCR4	31,35	Th1	46,49	CCR4	Th1	1233	51497	Gene	Gene	addition|nmod|START_ENTITY enhances|nsubj|addition enhances|nsubj|cells cells|amod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
23731651	0	CCR4	129,133	calcitonin_gene-related_peptide	56,87	CCR4	calcitonin gene-related peptide	1233	796	Gene	Gene	induces|nmod|START_ENTITY induces|xcomp|END_ENTITY	CCL17/thymus and activation-regulated chemokine induces calcitonin_gene-related_peptide in human airway epithelial cells through CCR4 .
18811584	0	CCR5	131,135	CCL27	111,116	CCR5	CCL27	1234	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
10967026	0	CCR5	111,115	CCR2	45,49	CCR5	CCR2	1234	729230	Gene	Gene	surface|dobj|START_ENTITY surface|nsubj|Influence Influence|nmod|polymorphisms polymorphisms|nmod|gene gene|compound|END_ENTITY	Influence of nucleotide polymorphisms in the CCR2 gene and the CCR5 promoter on the expression of cell surface CCR5 and CXCR4 .
12807425	0	CCR5	23,27	CCR2	160,164	CCR5	CCR2	12774(Tax:10090)	12772(Tax:10090)	Gene	Gene	mediator|nsubj|START_ENTITY mediator|dep|evidence evidence|nmod|effect effect|nmod|END_ENTITY	The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic_acid-induced hippocampal_injury : evidence for a compensatory effect by increased CCR2 and CCR3 .
14685276	0	CCR5	29,33	CCR2	80,84	CCR5	CCR2	1234	729230	Gene	Gene	receptors|compound|START_ENTITY HIV-1_infection|nmod|receptors HIV-1_infection|acl|acting acting|nmod|trans trans|nmod|receptor receptor|compound|END_ENTITY	Blocking HIV-1_infection via CCR5 and CXCR4 receptors by acting in trans on the CCR2 chemokine receptor .
16055130	0	CCR5	60,64	CCR2	46,50	CCR5	CCR2	1234	729230	Gene	Gene	CC-chemokine_receptor-2|appos|START_ENTITY CC-chemokine_receptor-2|appos|END_ENTITY	Polymorphisms in the CC-chemokine_receptor-2 -LRB- CCR2 -RRB- and -5 -LRB- CCR5 -RRB- genes and risk of coronary_heart_disease among US women .
16596402	0	CCR5	40,44	CCR2	125,129	CCR5	CCR2	100101579(Tax:9986)	100358097(Tax:9986)	Gene	Gene	variation|nmod|START_ENTITY variation|dep|alteration alteration|nmod|domain domain|nmod|conversion conversion|nmod|END_ENTITY	Genetic variation at chemokine receptor CCR5 in leporids : alteration at the 2nd extracellular domain by gene conversion with CCR2 in Oryctolagus , but not in Sylvilagus and Lepus species .
21454357	0	CCR5	30,34	CCR2	25,29	CCR5	CD16	1234	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Paradoxical role of CD16 + CCR2 + CCR5 + monocytes in tuberculosis : efficient APC in pleural_effusion but also mark disease severity in blood .
22285384	0	CCR5	60,64	CCR2	46,50	CCR5	CCR2	1234	729230	Gene	Gene	CC-chemokine_receptor-2|appos|START_ENTITY CC-chemokine_receptor-2|appos|END_ENTITY	Polymorphisms in the CC-chemokine_receptor-2 -LRB- CCR2 -RRB- and -5 -LRB- CCR5 -RRB- genes and risk of myocardial_infarction among Tunisian male patients .
23426986	0	CCR5	102,106	CCR2	42,46	CCR5	CCR2	1234	729230	Gene	Gene	evaluating|dobj|START_ENTITY monocytes|acl:relcl|evaluating improves|nmod|monocytes improves|dobj|detection detection|nmod|END_ENTITY	Sequential staining improves detection of CCR2 and CX3CR1 on monocytes when simultaneously evaluating CCR5 by multicolor flow cytometry .
18811584	0	CCR5	131,135	CCR4	125,129	CCR5	CCR4	1234	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18832886	0	CCR5	41,45	CCR5	61,65	CCR5	CCR5	1234	1234	Gene	Gene	antagonists|nummod|START_ENTITY antagonists|nmod|END_ENTITY	Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients .
18832886	0	CCR5	61,65	CCR5	41,45	CCR5	CCR5	1234	1234	Gene	Gene	antagonists|nmod|START_ENTITY antagonists|nummod|END_ENTITY	Primary genotypic resistance of HIV-1 to CCR5 antagonists in CCR5 antagonist treatment-naive patients .
20560795	0	CCR5	30,34	CCR5	84,88	CCR5	CCR5	1234	1234	Gene	Gene	blocker|appos|START_ENTITY has|nsubj|blocker has|dobj|effects effects|nmod|+ +|compound|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
20560795	0	CCR5	84,88	CCR5	30,34	CCR5	CCR5	1234	1234	Gene	Gene	+|compound|START_ENTITY effects|nmod|+ has|dobj|effects has|nsubj|blocker blocker|appos|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
21827290	0	CCR5	62,66	CC_chemokine_receptor	39,60	CCR5	CC chemokine receptor	1234	1234	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Analysis of peripheral T cells and the CC_chemokine_receptor -LRB- CCR5 -RRB- delta32 polymorphism in prostate_cancer patients treated with carboxymethyl-glucan -LRB- CM-G -RRB- .
10085131	0	CCR5	66,70	CC_chemokine_receptor_5	41,64	CCR5	CC chemokine receptor 5	117029(Tax:10116)	117029(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Differential effects of CC chemokines on CC_chemokine_receptor_5 -LRB- CCR5 -RRB- phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus .
11354628	0	CCR5	41,45	CC_chemokine_receptor_5	16,39	CCR5	CC chemokine receptor 5	1234	1234	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Analysis of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- delta-32 polymorphism in inflammatory_bowel_disease .
11803051	0	CCR5	25,29	CC_chemokine_receptor_5	0,23	CCR5	CC chemokine receptor 5	1234	1234	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	CC_chemokine_receptor_5 -LRB- CCR5 -RRB- mRNA expression in pulmonary_sarcoidosis .
12403770	0	CCR5	55,59	CC_chemokine_receptor_5	30,53	CCR5	CC chemokine receptor 5	1234	1234	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of ligand-stimulated CC_chemokine_receptor_5 -LRB- CCR5 -RRB- phosphorylation in intact cells using phosphosite-specific antibodies .
12919745	0	CCR5	52,56	CC_chemokine_receptor_5	27,50	CCR5	CC chemokine receptor 5	12774(Tax:10090)	12774(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Functional analysis of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- on virus-specific CD8 + T cells following coronavirus infection_of_the_central_nervous_system .
15009175	0	CCR5	41,45	CC_chemokine_receptor_5	16,39	CCR5	CC chemokine receptor 5	1234	1234	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Analysis of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- Delta32 polymorphism in Beh et 's disease .
15787642	0	CCR5	127,131	CC_chemokine_receptor_5	102,125	CCR5	CC chemokine receptor 5	1234	1234	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Distribution of human chemokine _ -LRB- C-X3-C -RRB- _ receptor_1 -LRB- CX3CR1 -RRB- gene polymorphisms and haplotypes of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- promoter in Chinese people , and the effects of CCR5 haplotypes on CCR5 expression .
22664873	0	CCR5	26,30	CD103	80,85	CCR5	CD103	12774(Tax:10090)	16407(Tax:10090)	Gene	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103 + effector/memory regulatory T cells .
21454357	0	CCR5	30,34	CD16	20,24	CCR5	CD16	1234	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Paradoxical role of CD16 + CCR2 + CCR5 + monocytes in tuberculosis : efficient APC in pleural_effusion but also mark disease severity in blood .
26330348	0	CCR5	113,117	CD16	34,38	CCR5	CD16	1234	2214	Gene	Gene	pathways|compound|START_ENTITY engagement|nmod|pathways sinusoids|nmod|engagement retained|nmod|sinusoids retained|nsubjpass|cells cells|amod|END_ENTITY	Human liver-resident CD56 -LRB- bright -RRB- / CD16 -LRB- neg -RRB- NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways .
16002422	0	CCR5	18,22	CD25	52,56	CCR5	CD25	12774(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Critical role for CCR5 in the function of donor CD4 + CD25 + regulatory T cells during acute_graft-versus-host_disease .
12865065	0	CCR5	15,19	CD28	55,59	CCR5	CD28	1234	940	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Differences in CCR5 expression on peripheral blood CD4 + CD28 - T-cells and in granulomatous_lesions between localized and generalized Wegener 's _ granulomatosis .
10226056	0	CCR5	89,93	CD4	0,3	CCR5	CD4	1234	920	Gene	Gene	CCR3|nmod|START_ENTITY receptor-dependent|dep|CCR3 receptor-dependent|nsubj|END_ENTITY	CD4 receptor-dependent entry of human_immunodeficiency_virus_type-1 env-pseudotypes into CCR5 - , CCR3 - , and CXCR4-expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor .
10413516	0	CCR5	53,57	CD4	86,89	CCR5	CD4	1234	920	Gene	Gene	site|compound|START_ENTITY epitopes|nmod|site gp120|nmod|epitopes changes|nmod|gp120 induced|nsubjpass|changes induced|nmod|END_ENTITY	Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic .
10438877	0	CCR5	158,162	CD4	78,81	CCR5	CD4	1234	920	Gene	Gene	concentrations|nmod|START_ENTITY exploit|dobj|concentrations capacity|acl|exploit determined|nmod|capacity determined|nsubj|tropism tropism|acl|END_ENTITY	Expanded tropism of primary human_immunodeficiency_virus_type_1 R5 strains to CD4 -LRB- + -RRB- T-cell lines determined by the capacity to exploit low concentrations of CCR5 .
10720514	0	CCR5	20,24	CD4	0,3	CCR5	CD4	1234	920	Gene	Gene	START_ENTITY|nsubj|surface surface|compound|END_ENTITY	CD4 + T cell surface CCR5 density as a determining factor of virus_load_in_persons_infected with human_immunodeficiency_virus_type_1 .
10720515	0	CCR5	92,96	CD4	100,103	CCR5	CD4	1234	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Interleukin-2 up-regulates expression of the human_immunodeficiency_virus fusion coreceptor CCR5 by CD4 + lymphocytes in vivo .
10816381	0	CCR5	16,20	CD4	36,39	CCR5	CD4	1234	920	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells .
10864687	0	CCR5	40,44	CD4	33,36	CCR5	CD4	1234	920	Gene	Gene	infection|dep|START_ENTITY infection|nmod|END_ENTITY	CD4-independent infection of two CD4 -LRB- - -RRB- / CCR5 -LRB- - -RRB- / CXCR4 -LRB- + -RRB- pre-T-cell lines by human and simian immunodeficiency viruses .
10961886	0	CCR5	22,26	CD4	123,126	CCR5	CD4	1234	920	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|stimulation stimulation|nmod|T T|compound|END_ENTITY	Kinetics of CXCR4 and CCR5 up-regulation and human_immunodeficiency_virus expansion after antigenic stimulation of primary CD4 -LRB- + -RRB- T lymphocytes .
10967018	0	CCR5	102,106	CD4	58,61	CCR5	CD4	1234	920	Gene	Gene	T|compound|START_ENTITY CD45RO|appos|T END_ENTITY|appos|CD45RO	Adenoids provide a microenvironment for the generation of CD4 -LRB- + -RRB- , CD45RO -LRB- + -RRB- , L-selectin -LRB- - -RRB- , CXCR4 -LRB- + -RRB- , CCR5 -LRB- + -RRB- T lymphocytes , a lymphocyte phenotype found in the middle_ear_effusion .
11069995	0	CCR5	12,16	CD4	31,34	CCR5	CD4	1234	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Dynamics of CCR5 expression by CD4 -LRB- + -RRB- T cells in lymphoid tissues during simian immunodeficiency_virus_infection .
11181150	0	CCR5	22,26	CD4	56,59	CCR5	CD4	1234	920	Gene	Gene	+|compound|START_ENTITY turnover|nmod|+ turnover|dep|lymphocytes lymphocytes|compound|END_ENTITY	Increased turnover of CCR5 + and redistribution of CCR5 - CD4 T lymphocytes during primary human_immunodeficiency_virus_type_1_infection .
11181150	0	CCR5	50,54	CD4	56,59	CCR5	CD4	1234	920	Gene	Gene	turnover|nmod|START_ENTITY turnover|dep|lymphocytes lymphocytes|compound|END_ENTITY	Increased turnover of CCR5 + and redistribution of CCR5 - CD4 T lymphocytes during primary human_immunodeficiency_virus_type_1_infection .
11500825	0	CCR5	29,33	CD4	79,82	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	A critical role for IL-12 in CCR5 induction on T_cell_receptor-triggered mouse CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
11546936	0	CCR5	19,23	CD4	0,3	CCR5	CD4	1234	920	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	CD4 T cell surface CCR5 density as a host factor in HIV-1_disease_progression .
11751947	0	CCR5	17,21	CD4	79,82	CCR5	CD4	1234	920	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4 + T lymphocytes .
11811785	0	CCR5	87,91	CD4	106,109	CCR5	CD4	1234	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	IFN-alpha acts on T-cell_receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4 + and CD8 + T cells .
11839399	0	CCR5	51,55	CD4	78,81	CCR5	CD4	1234	920	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|T T|compound|END_ENTITY	Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4 -LRB- + -RRB- T cells in the cervical epithelium of healthy women .
12056598	0	CCR5	25,29	CD4	57,60	CCR5	CD4	1234	920	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|surface surface|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Decreased density of the CCR5 receptor on the surface of CD4 + lymphocytes and monocytes/macrophages is associated with the CCR5-59653T transition in the promoter region .
12131184	0	CCR5	0,4	CD4	103,106	CCR5	CD4	1234	920	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|apoptosis apoptosis|acl|uninfected uninfected|dobj|cells cells|compound|END_ENTITY	CCR5 mediates Fas - and caspase-8 dependent apoptosis of both uninfected and HIV infected primary human CD4 T cells .
12477875	0	CCR5	110,114	CD4	0,3	CCR5	CD4	1234	920	Gene	Gene	interaction|nmod|START_ENTITY inhibit|dobj|interaction inhibit|nsubj|antibodies antibodies|nummod|END_ENTITY	CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5 .
12599050	0	CCR5	44,48	CD4	8,11	CCR5	CD4	1234	920	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|cells cells|compound|END_ENTITY	Vaginal CD4 + T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency_virus_infection .
12619446	0	CCR5	20,24	CD4	26,29	CCR5	CD4	1234	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased number of CCR5 + CD4 T cells among south Indian adults probably associated with the low frequency of X4 phenotype of HIV-1 in India .
12689415	0	CCR5	10,14	CD4	29,32	CCR5	CD4	1234	713807(Tax:9544)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Decreased CCR5 expression on CD4 + T cells of SIV-infected sooty mangabeys .
12699431	0	CCR5	14,18	CD4	59,62	CCR5	CD4	1234	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of CCR5 expression and MIP-1alpha production in CD4 + T cells from patients with rheumatoid_arthritis .
12865065	0	CCR5	15,19	CD4	51,54	CCR5	CD4	1234	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|CD28 CD28|compound|END_ENTITY	Differences in CCR5 expression on peripheral blood CD4 + CD28 - T-cells and in granulomatous_lesions between localized and generalized Wegener 's _ granulomatosis .
12878220	0	CCR5	55,59	CD4	23,26	CCR5	CD4	1234	920	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of soluble CD4 with the chemokine receptor CCR5 .
14607889	0	CCR5	82,86	CD4	20,23	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	requirement|nmod|START_ENTITY migration|dep|requirement induces|dobj|migration induces|nsubj|END_ENTITY	Cutting edge : IL-16 / CD4 preferentially induces Th1 cell migration : requirement of CCR5 .
14645006	0	CCR5	73,77	CD4	47,50	CCR5	CD4	1234	920	Gene	Gene	+|compound|START_ENTITY lymphocytes|nmod|+ lymphocytes|nsubj|Identification Identification|acl|circulating circulating|dobj|T T|compound|END_ENTITY	Identification of circulating antigen-specific CD4 + T lymphocytes with a CCR5 + , cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV_infection .
15117454	0	CCR5	60,64	CD4	100,103	CCR5	CD4	1234	920	Gene	Gene	human_immunodeficiency_virus_type_1_infection|nmod|START_ENTITY Effects|nmod|human_immunodeficiency_virus_type_1_infection coreceptor|nsubj|Effects coreceptor|dobj|expression expression|nmod|subsets subsets|compound|END_ENTITY	Effects of human_immunodeficiency_virus_type_1_infection on CCR5 and CXCR4 coreceptor expression on CD4 T lymphocyte subsets in infants and adolescents .
15379987	0	CCR5	5,9	CD4	0,3	CCR5	CD4	1234	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CCR5 + and CD4 + CCR3 + lymphocyte subset and monocyte apoptosis in patients with acute visceral_leishmaniasis .
15459144	0	CCR5	13,17	CD4	19,22	CCR5	CD4	1234	920	Gene	Gene	T-lymphocytes|compound|START_ENTITY T-lymphocytes|compound|END_ENTITY	Expansion of CCR5 + CD4 + T-lymphocytes in the course of active pulmonary_tuberculosis .
15498817	0	CCR5	31,35	CD4	11,14	CCR5	CD4	1234	920	Gene	Gene	expression|nummod|START_ENTITY surface|dobj|expression surface|nsubj|cell cell|compound|END_ENTITY	Diminished CD4 + T cell surface CCR5 expression in alcoholic patients .
15660419	0	CCR5	41,45	CD4	75,78	CCR5	CD4	1234	920	Gene	Gene	surface|dobj|START_ENTITY surface|nmod|presence presence|nmod|END_ENTITY	Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4 .
15905189	0	CCR5	23,27	CD4	58,61	CCR5	CD4	1234	920	Gene	Gene	CD38|compound|START_ENTITY CD38|amod|antigen-specific antigen-specific|dep|END_ENTITY	Early proliferation of CCR5 -LRB- + -RRB- CD38 -LRB- + + + -RRB- antigen-specific CD4 -LRB- + -RRB- Th1 effector cells during primary HIV-1_infection .
16002422	0	CCR5	18,22	CD4	48,51	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|function function|nmod|CD25 CD25|compound|END_ENTITY	Critical role for CCR5 in the function of donor CD4 + CD25 + regulatory T cells during acute_graft-versus-host_disease .
16249699	0	CCR5	56,60	CD4	50,53	CCR5	CD4	1234	920	Gene	Gene	CXCR4|compound|START_ENTITY CXCR4|amod|R5_HIV-1 R5_HIV-1|nmod|HIV-1 HIV-1|nmod|END_ENTITY	Enhanced replication of R5_HIV-1 over X4 HIV-1 in CD4 -LRB- + -RRB- CCR5 -LRB- + -RRB- CXCR4 -LRB- + -RRB- T cells .
16455991	0	CCR5	80,84	CD4	50,53	CCR5	CD4	1234	920	Gene	Gene	cholesterol|amod|START_ENTITY dependent|nmod|cholesterol dependent|nsubj|signaling signaling|compound|END_ENTITY	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
16791011	0	CCR5	73,77	CD4	54,57	CCR5	CD4	1234	920	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	The efficiency of R5_HIV-1_infection is determined by CD4 T-cell surface CCR5 density through G alpha i-protein signalling .
16899302	0	CCR5	33,37	CD4	28,31	CCR5	CD4	1234	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient Fas expression by CD4 + CCR5 + T cells in multiple_sclerosis .
17003371	0	CCR5	15,19	CD4	11,14	CCR5	CD4	1234	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Paucity of CD4 + CCR5 + T cells is a typical feature of natural SIV hosts .
17520029	0	CCR5	16,20	CD4	53,56	CCR5	CD4	1234	920	Gene	Gene	levels|compound|START_ENTITY disrupt|dobj|levels disrupt|nmod|T T|compound|END_ENTITY	Statins disrupt CCR5 and RANTES expression levels in CD4 -LRB- + -RRB- T lymphocytes in vitro and preferentially decrease infection_of_R5_versus_X4_HIV-1 .
17545708	0	CCR5	0,4	CD4	31,34	CCR5	CD4	1234	920	Gene	Gene	levels|nummod|START_ENTITY levels|nmod|cells cells|compound|END_ENTITY	CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5_HIV-1 .
17765942	0	CCR5	82,86	CD4	56,59	CCR5	CD4	1234	920	Gene	Gene	ligands|nummod|START_ENTITY secrete|dobj|ligands T|xcomp|secrete T|nsubj|END_ENTITY	Antigen stimulation induces HIV envelope gp120-specific CD4 -LRB- + -RRB- T cells to secrete CCR5 ligands and suppress HIV_infection .
17855336	0	CCR5	43,47	CD4	0,3	CCR5	CD4	1234	920	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD4 interacts constitutively with multiple CCR5 at the plasma membrane of living cells .
18025874	0	CCR5	40,44	CD4	29,32	CCR5	CD4	1234	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Early restoration of mucosal CD4 memory CCR5 T cells in the gut of SIV-infected rhesus predicts long term non-progression .
18097220	0	CCR5	0,4	CD4	54,57	CCR5	CD4	1234	920	Gene	Gene	use|nsubj|START_ENTITY influences|dep|use influences|dobj|relationship relationship|nmod|END_ENTITY	CCR5 or CXCR4 use influences the relationship between CD4 cell depletion , NKp44L expression and NK cytotoxicity in SHIV-infected macaques .
18462992	0	CCR5	18,22	CD4	36,39	CCR5	CD4	1234	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Downregulation of CCR5 on activated CD4 T cells in HIV-infected Indians .
19302742	0	CCR5	61,65	CD4	79,82	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	CCR3|nummod|START_ENTITY receptors|dep|CCR3 receptors|nmod|T T|compound|END_ENTITY	Relationship between expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells and spontaneous_abortion in mice .
19781371	0	CCR5	40,44	CD4	58,61	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	CCR3|nummod|START_ENTITY receptors|dep|CCR3 receptors|nmod|T T|compound|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
20381825	0	CCR5	19,23	CD4	27,30	CCR5	CD4	1234	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Constrained use of CCR5 on CD4 + lymphocytes by R5X4_HIV-1 : efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry .
20560795	0	CCR5	30,34	CD4	89,92	CCR5	CD4	1234	920	Gene	Gene	blocker|appos|START_ENTITY has|nsubj|blocker has|dobj|effects effects|nmod|+ +|compound|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
20560795	0	CCR5	84,88	CD4	89,92	CCR5	CD4	1234	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
20710056	0	CCR5	77,81	CD4	114,117	CCR5	CD4	1234	920	Gene	Gene	START_ENTITY|nmod|T-cells T-cells|compound|END_ENTITY	GB_virus_C coinfection in advanced HIV_type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4 -LRB- + -RRB- T-cells .
21035160	0	CCR5	47,51	CD4	81,84	CCR5	CD4	735311(Tax:9544)	713807(Tax:9544)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T-cells T-cells|compound|END_ENTITY	TCR triggering transcriptionally downregulates CCR5 expression on rhesus_macaque CD4 -LRB- + -RRB- T-cells with no measurable effect on susceptibility to SIV_infection .
21068438	0	CCR5	79,83	CD4	18,21	CCR5	CD4	1234	920	Gene	Gene	pools|nmod|START_ENTITY have|dobj|pools have|nsubj|END_ENTITY	Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5 .
21239363	0	CCR5	20,24	CD4	40,43	CCR5	CD4	1234	920	Gene	Gene	antagonists|nummod|START_ENTITY antagonists|nmod|gain gain|compound|END_ENTITY	The relationship of CCR5 antagonists to CD4 + T-cell gain : a meta-regression of recent clinical trials in treatment-experienced HIV-infected patients .
21291552	0	CCR5	104,108	CD4	100,103	CCR5	CD4	1234	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vaccination with live attenuated simian_immunodeficiency_virus causes dynamic changes in intestinal CD4 + CCR5 + T cells .
21524671	0	CCR5	148,152	CD4	118,121	CCR5	CD4	1234	920	Gene	Gene	TAK-779|compound|START_ENTITY varied|nmod|TAK-779 varied|nmod|ability ability|nmod|usages usages|compound|END_ENTITY	HIV-1 clade C envelopes obtained from late stage symptomatic Indian patients varied in their ability towards relative CD4 usages and sensitivity to CCR5 antagonist TAK-779 .
21715565	0	CCR5	54,58	CD4	78,81	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
22083068	0	CCR5	0,4	CD4	44,47	CCR5	CD4	1234	920	Gene	Gene	expression|compound|START_ENTITY elevated|nsubjpass|expression elevated|nmod|cells cells|compound|END_ENTITY	CCR5 expression is elevated on endocervical CD4 + T cells in healthy postmenopausal women .
23185351	0	CCR5	5,9	CD4	36,39	CCR5	CD4	1234	920	Gene	Gene	density|compound|START_ENTITY density|nmod|cells cells|compound|END_ENTITY	High CCR5 density on central memory CD4 + T cells in acute_HIV-1_infection is mostly associated with rapid disease progression .
23977659	0	CCR5	12,16	CD4	59,62	CCR5	CD4	1234	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
24312168	0	CCR5	70,74	CD4	54,57	CCR5	CD4	1234	920	Gene	Gene	START_ENTITY|nsubj|Detection Detection|nmod|antibodies antibodies|nmod|END_ENTITY	Detection of HIV-1 neutralizing antibodies in a human CD4 / CXCR4 / CCR5 T-lymphoblastoid cell assay system .
24597865	0	CCR5	16,20	CD4	35,38	CCR5	CD4	1234	920	Gene	Gene	editing|nmod|START_ENTITY editing|nmod|cells cells|compound|END_ENTITY	Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV .
24999042	0	CCR5	61,65	CD4	74,77	CCR5	CD4	1234	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	HIV replication in conjunction with granzyme_B production by CCR5 + memory CD4 T cells : Implications for bystander cell and tissue pathologies .
25268493	0	CCR5	85,89	CD4	80,83	CCR5	CD4	1234	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	The Inner Foreskin of Healthy Males at Risk of HIV Infection Harbors Epithelial CD4 + CCR5 + Cells and Has Features of an Inflamed Epidermal Barrier .
25268698	0	CCR5	0,4	CD4	29,32	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	Editing|compound|START_ENTITY Editing|nmod|T T|compound|END_ENTITY	CCR5 Gene Editing of Resting CD4 -LRB- + -RRB- T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice .
25495598	0	CCR5	14,18	CD4	30,33	CCR5	CD4	1234	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	The number of CCR5 expressing CD4 + T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors : a cross-sectional study .
25550504	0	CCR5	14,18	CD4	10,13	CCR5	CD4	1234	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD4 + CCR5 + T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus_macaques .
25550504	0	CCR5	14,18	CD4	10,13	CCR5	CD4	1234	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD4 + CCR5 + T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus_macaques .
25834861	0	CCR5	64,68	CD4	72,75	CCR5	CD4	1234	920	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Heroin use in Indonesia is associated with higher expression of CCR5 on CD4 + cells and lower ex-vivo production of CCR5 ligands .
27021296	0	CCR5	0,4	CD4	27,30	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
27026376	0	CCR5	0,4	CD4	72,75	CCR5	CD4	1234	920	Gene	Gene	interaction|nummod|START_ENTITY contributes|nsubj|interaction contributes|nmod|depletion depletion|nmod|cells cells|compound|END_ENTITY	CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo .
9581779	0	CCR5	120,124	CD4	31,34	CCR5	CD4	1234	920	Gene	Gene	expression|nmod|START_ENTITY association|nmod|expression Reduced_HIV-1_infectability|dep|association Reduced_HIV-1_infectability|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Reduced_HIV-1_infectability of CD4 + lymphocytes from exposed-uninfected individuals : association with low expression of CCR5 and high production of beta-chemokines .
9811784	0	CCR5	210,214	CD4	21,24	CCR5	CD4	12774(Tax:10090)	920	Gene	Gene	upregulation|nmod|START_ENTITY become|nmod|upregulation END_ENTITY|acl:relcl|become	Human lymphoblastoid CD4 -LRB- + -RRB- T cells become permissive to macrophage-tropic strains of human_immunodeficiency_virus_type_1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5 : in vivo dynamics of CD4 -LRB- + -RRB- T-cell differentiation in pathogenesis of AIDS .
9811784	0	CCR5	210,214	CD4	236,239	CCR5	CD4	12774(Tax:10090)	12504(Tax:10090)	Gene	Gene	upregulation|nmod|START_ENTITY become|nmod|upregulation become|nmod|dynamics dynamics|nmod|T-cell T-cell|compound|END_ENTITY	Human lymphoblastoid CD4 -LRB- + -RRB- T cells become permissive to macrophage-tropic strains of human_immunodeficiency_virus_type_1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5 : in vivo dynamics of CD4 -LRB- + -RRB- T-cell differentiation in pathogenesis of AIDS .
10940868	0	CCR5	10,14	CD8	16,19	CCR5	CD8	1234	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCR2 + and CCR5 + CD8 + T cells increase during viral_infection_and_migrate_to_sites_of_infection .
12819030	0	CCR5	70,74	CD8	13,16	CCR5	CD8	1234	925	Gene	Gene	express|dobj|START_ENTITY cells|ccomp|express cells|compound|END_ENTITY	Infiltrating CD8 + T cells in oral_lichen_planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10 / CXCL10 in their cytolytic granules : a potential self-recruiting mechanism .
20560795	0	CCR5	98,102	CD8	103,106	CCR5	CD8	1234	925	Gene	Gene	numbers|compound|START_ENTITY numbers|compound|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
22918850	0	CCR5	18,22	CD8	58,61	CCR5	CD8	1234	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Downregulation of CCR5 expression on the peripheral blood CD8 + T cells of southeastern Iranian patients with chronic hepatitis_B_infection .
25589222	0	CCR5	19,23	CD8	81,84	CCR5	CD8	1234	925	Gene	Gene	antagonists|nummod|START_ENTITY use|nmod|antagonists supported|nsubjpass|use supported|nmod|expression expression|nmod|cells cells|amod|CCR5 CCR5|nmod|T T|compound|END_ENTITY	Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8 -LRB- + -RRB- T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory_syndrome .
25589222	0	CCR5	73,77	CD8	81,84	CCR5	CD8	1234	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8 -LRB- + -RRB- T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory_syndrome .
26994221	0	CCR5	18,22	CD8	43,46	CCR5	CD8	1234	925	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Transient Surface CCR5 Expression by Naive CD8 + T Cells within Inflamed Lymph Nodes Is Dependent on High Endothelial Venule Interaction and Augments Th Cell-Dependent Memory Response .
27068801	0	CCR5	11,15	CD8	78,81	CCR5	CD8	1234	925	Gene	Gene	CD4|compound|START_ENTITY role|nmod|CD4 T|nsubj|role T|nmod|cells cells|compound|END_ENTITY	A role for CCR5 -LRB- + -RRB- CD4 T cells in cutaneous psoriasis and for CD103 -LRB- + -RRB- CCR4 -LRB- + -RRB- CD8 Teff cells in the associated systemic_inflammation .
16455991	0	CCR5	80,84	CXCR3	19,24	CCR5	CXCR3	1234	2833	Gene	Gene	cholesterol|amod|START_ENTITY dependent|nmod|cholesterol END_ENTITY|parataxis|dependent	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
18811584	0	CCR5	131,135	CXCR3	137,142	CCR5	CXCR3	1234	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
22079021	0	CCR5	104,108	CXCR3	90,95	CCR5	CXCR3	1234	2833	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	T lymphocyte recruitment into renal_cell_carcinoma tissue : a role for chemokine receptors CXCR3 , CXCR6 , CCR5 , and CCR6 .
25180533	0	CCR5	8,12	CXCR3	0,5	CCR5	CXCR3	1234	2833	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CXCR3 CCR5 T cells and autoimmune_diseases : guilty as charged ?
16179731	0	CCR5	62,66	CXCR4	43,48	CCR5	CXCR4	1234	7852	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells .
22079021	0	CCR5	104,108	CXCR6	97,102	CCR5	CXCR6	1234	10663	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	T lymphocyte recruitment into renal_cell_carcinoma tissue : a role for chemokine receptors CXCR3 , CXCR6 , CCR5 , and CCR6 .
23852305	0	CCR5	22,26	Chemokine_receptor_5	0,20	CCR5	Chemokine receptor 5	1234	1234	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Chemokine_receptor_5 -LRB- CCR5 -RRB- polymorphism in chronic hepatitis_B patients treated with three different nucleos -LRB- t -RRB- ide analogues .
27026376	0	CCR5	0,4	Env	28,31	CCR5	Env	1234	155971(Tax:11676)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo .
27021296	0	CCR5	0,4	FoxP3	11,16	CCR5	FoxP3	12774(Tax:10090)	20371(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
16091457	0	CCR5	86,90	GATA-1	21,27	CCR5	GATA-1	1234	2623	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells .
17971448	0	CCR5	81,85	Gp120	0,5	CCR5	Gp120	1234	155971(Tax:11676)	Gene	Gene	due|nmod|START_ENTITY impairment_of_R5_HIV-1_infectivity|xcomp|due impairment_of_R5_HIV-1_infectivity|nsubj|V3-dependent V3-dependent|amod|END_ENTITY	Gp120 V3-dependent impairment_of_R5_HIV-1_infectivity due to virion-incorporated CCR5 .
12166499	0	CCR5	114,118	HLA-DRB1	99,107	CCR5	HLA-DRB1	1234	3123	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Disease severity in Danish multiple_sclerosis patients evaluated by MRI and three genetic markers -LRB- HLA-DRB1 * 1501 , CCR5 deletion mutation , apolipoprotein_E -RRB- .
18811584	0	CCR5	131,135	IFN-beta	161,169	CCR5	IFN-beta	1234	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
10392758	0	CCR5	19,23	IL-10	0,5	CCR5	IL-10	1234	3586	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-10 up-regulates CCR5 gene expression in human monocytes .
18811584	0	CCR5	131,135	IP-10	118,123	CCR5	IP-10	1234	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
10720515	0	CCR5	92,96	Interleukin-2	0,13	CCR5	Interleukin-2	1234	3558	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin-2 up-regulates expression of the human_immunodeficiency_virus fusion coreceptor CCR5 by CD4 + lymphocytes in vivo .
16621960	0	CCR5	35,39	Lyn	15,18	CCR5	Lyn	1234	4067	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1_gp120 in human macrophages .
25132583	0	CCR5	171,175	MCP-1	177,182	CCR5	MCP-1	1234	6347	Gene	Gene	IL-10|compound|START_ENTITY IL-10|dep|END_ENTITY	Incidence and dynamics of active cytomegalovirus_infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms in donor and recipient CCR5 , MCP-1 , IL-10 , and TLR9 genes .
12427015	0	CCR5	60,64	MIP-1_beta	46,56	CCR5	MIP-1 beta	1234	6351	Gene	Gene	binding|compound|START_ENTITY END_ENTITY|nmod|binding	Characterization of the role of the N-loop of MIP-1_beta in CCR5 binding .
18811584	0	CCR5	131,135	MIP-1alpha	99,109	CCR5	MIP-1alpha	1234	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCR5	131,135	PD1	144,147	CCR5	PD1	1234	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CCR5	131,135	PDL2	149,153	CCR5	PDL2	1234	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
11108946	0	CCR5	33,37	RANTES	56,62	CCR5	RANTES	1234	6352	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1alpha by interferon-beta .
18588983	0	CCR5	70,74	RANTES	120,126	CCR5	RANTES	1234	6352	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Large-scale expression and purification of the major HIV-1 coreceptor CCR5 and characterization of its interaction with RANTES .
19213338	0	CCR5	79,83	RANTES	59,65	CCR5	RANTES	1234	6352	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Regulatory effect of ligustrazine and Radix astragalus on RANTES and receptor CCR5 expression in the genesis and development process of endometriosis -RSB- .
16249462	0	CCR5	117,121	RANTES_receptor	95,110	CCR5	RANTES receptor	1234	1230	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Risk of diabetic_nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES_receptor gene -LRB- CCR5 -RRB- : a sex-specific effect .
10747947	0	CCR5	24,28	SHP1	45,49	CCR5	SHP1	1234	8431	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Beta-chemokine receptor CCR5 signals through SHP1 , SHP2 , and Syk .
27021296	0	CCR5	0,4	T-bet	5,10	CCR5	T-bet	12774(Tax:10090)	57765(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
11213625	0	CCR5	50,54	chemokine_receptor	55,73	CCR5	chemokine receptor	1234	7852	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Distribution of the 32 base pair deletion of the CCR5 chemokine_receptor gene in different regions of Ukraine -RSB- .
11994442	0	CCR5	110,114	chemokine_receptor	12,30	CCR5	chemokine receptor	1234	7852	Gene	Gene	expression|nmod|START_ENTITY lymphocytes|dep|expression expression|nmod|lymphocytes expression|compound|END_ENTITY	Patterns of chemokine_receptor expression on peripheral blood gamma delta T lymphocytes : strong expression of CCR5 is a selective feature of V delta 2/V gamma 9 gamma delta T cells .
20801883	0	CCR5	81,85	chemokine_receptor	52,70	CCR5	chemokine receptor	1234	7852	Gene	Gene	internalization|compound|START_ENTITY internalization|amod|END_ENTITY	Na + / H + exchanger regulatory factor-1 is involved in chemokine_receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer .
22815758	0	CCR5	75,79	chemokine_receptor	80,98	CCR5	chemokine receptor	1234	7852	Gene	Gene	chaperone|nmod|START_ENTITY END_ENTITY|nsubj|chaperone	Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine_receptor signaling complex organization .
9480225	0	CCR5	99,103	chemokine_receptor	80,98	CCR5	chemokine receptor	1234	7852	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A simple and rapid method for determining a 32-bp deletion in the gene for the chemokine_receptor CCR5 -RSB- .
16879946	0	CCR5	99,103	chemokine_receptor_5	77,97	CCR5	chemokine receptor 5	1234	1234	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A closed-tube assay for genotyping of the 32-bp deletion polymorphism in the chemokine_receptor_5 -LRB- CCR5 -RRB- gene : dissociation analysis of amplified fragments of DNA .
17067435	0	CCR5	37,41	chemokine_receptor_5	15,35	CCR5	chemokine receptor 5	1234	1234	Gene	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	Association of chemokine_receptor_5 -LRB- CCR5 -RRB- delta32 mutation with Beh __ et 's _ disease is dependent on gender in Iranian patients .
18179389	0	CCR5	40,44	chemokine_receptor_5	18,38	CCR5	chemokine receptor 5	1234	1234	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A deletion in the chemokine_receptor_5 -LRB- CCR5 -RRB- gene is associated with tickborne encephalitis .
25785041	0	CCR5	42,46	chemokine_receptor_5	20,40	CCR5	chemokine receptor 5	1234	1234	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Association between chemokine_receptor_5 -LRB- CCR5 -RRB- delta32 gene variant and atherosclerosis : a meta-analysis of 13 studies .
10200301	0	CCR5	64,68	gp120	46,51	CCR5	gp120	1234	3700	Gene	Gene	utilization|compound|START_ENTITY involved|nmod|utilization END_ENTITY|acl|involved	Hypervariable region 3 residues of HIV_type_1 gp120 involved in CCR5 coreceptor utilization : therapeutic and prophylactic implications .
10333239	0	CCR5	177,181	gp120	149,154	CCR5	gp120	1234	3700	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Enhanced_human_immunodeficiency_virus_infection in macrophages by high-molecular-weight dextran sulfate is associated with conformational changes of gp120 and expression of the CCR5 receptor .
10413516	0	CCR5	53,57	gp120	26,31	CCR5	gp120	1234	3700	Gene	Gene	site|compound|START_ENTITY epitopes|nmod|site END_ENTITY|nmod|epitopes	Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic .
10438703	0	CCR5	140,144	gp120	69,74	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	expression|nmod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|peptide peptide|acl|derived derived|nmod|END_ENTITY	A synthetic peptide derived from human_immunodeficiency_virus_type_1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R .
10482572	0	CCR5	104,108	gp120	86,91	CCR5	gp120	1234	3700	Gene	Gene	utilization|compound|START_ENTITY involved|nmod|utilization involved|nsubj|Analysis Analysis|nmod|domain domain|nmod|loop loop|nmod|END_ENTITY	Analysis of the critical domain in the V3 loop of human_immunodeficiency_virus_type_1 gp120 involved in CCR5 utilization .
10758170	0	CCR5	80,84	gp120	6,11	CCR5	gp120	1234	3700	Gene	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	HIV-1 gp120 and chemokines_activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation .
10823934	0	CCR5	24,28	gp120	119,124	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY interaction|nmod|domain peptides|nsubj|interaction peptides|xcomp|containing containing|nmod|END_ENTITY	Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120 .
10938094	0	CCR5	55,59	gp120	111,116	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	terminus|nmod|START_ENTITY peptide|nmod|terminus interacts|nsubj|peptide interacts|nmod|epitope epitope|nmod|glycoprotein glycoprotein|amod|END_ENTITY	A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry .
12477875	0	CCR5	110,114	gp120	65,70	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5 .
12610158	0	CCR5	130,134	gp120	121,126	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	utilization|compound|START_ENTITY Effect|nmod|utilization Effect|nmod|END_ENTITY	Effect of amino_acid substitution of the V3 and bridging sheet residues in human_immunodeficiency_virus_type_1 subtype C gp120 on CCR5 utilization .
12887918	0	CCR5	73,77	gp120	102,107	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	region|compound|START_ENTITY region|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120 .
14517611	0	CCR5	56,60	gp120	90,95	CCR5	gp120	1234	3700	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies .
15321703	0	CCR5	80,84	gp120	71,76	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|HIV-1 HIV-1|nummod|END_ENTITY	A novel assay to identify entry inhibitors that block binding of HIV-1 gp120 to CCR5 .
15767436	0	CCR5	69,73	gp120	146,151	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	lacking|nsubj|START_ENTITY lacking|ccomp|have have|dobj|mutations mutations|nmod|END_ENTITY	Variants of human_immunodeficiency_virus_type_1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120 , including loss of a functional N-glycan .
15905975	0	CCR5	119,123	gp120	97,102	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	binding|compound|START_ENTITY critical|nmod|binding critical|nsubj|structure structure|nmod|END_ENTITY	Highly conserved beta16/beta17 beta-hairpin structure in human_immunodeficiency_virus_type_1 YU2 gp120 is critical for CCR5 binding .
16721558	0	CCR5	0,4	gp120	46,51	CCR5	gp120	1234	3700	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	CCR5 interactions with the variable 3 loop of gp120 .
17101166	0	CCR5	180,184	gp120	153,158	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	coreceptor|compound|START_ENTITY interaction|nmod|coreceptor interaction|amod|END_ENTITY	Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human_immunodeficiency_virus_type_1 gp120 interaction with the CCR5 coreceptor .
17239419	0	CCR5	108,112	gp120	28,33	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	heterozygote|compound|START_ENTITY contribute|nmod|heterozygote contribute|nsubj|Changes Changes|nmod|region region|nmod|END_ENTITY	Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote .
17273779	0	CCR5	132,136	gp120	69,74	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	interaction|nmod|START_ENTITY implications|nmod|interaction modeling|dep|implications modeling|nmod|peptides peptides|acl|derived derived|nmod|V3-loop V3-loop|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120 : implications of the interaction with chemokine receptor CCR5 .
17920626	0	CCR5	46,50	gp120	32,37	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	reduces|dobj|START_ENTITY reduces|nsubj|rheostat rheostat|nmod|HIV-1 HIV-1|nummod|END_ENTITY	An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations .
18190945	0	CCR5	26,30	gp120	162,167	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	vicriviroc|compound|START_ENTITY Mapping|nmod|vicriviroc reveals|dep|Mapping reveals|nmod|domain domain|nmod|END_ENTITY	Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120 .
19018669	0	CCR5	95,99	gp120	81,86	CCR5	gp120	1234	3700	Gene	Gene	coreceptor|compound|START_ENTITY protein|nmod|coreceptor protein|appos|END_ENTITY	High-affinity binding of southern African HIV_type_1 subtype C envelope protein , gp120 , to the CCR5 coreceptor .
19170639	0	CCR5	56,60	gp120	103,108	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	peptide|nmod|START_ENTITY thermodynamics|nmod|peptide coreceptor|nsubj|thermodynamics coreceptor|nmod|END_ENTITY	Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120 .
19776131	0	CCR5	128,132	gp120	67,72	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	vicriviroc|compound|START_ENTITY associated|nmod|vicriviroc mutations|acl|associated amino_acid|dobj|mutations amino_acid|nsubj|analysis analysis|nmod|END_ENTITY	Structure-function analysis of human_immunodeficiency_virus_type_1 gp120 amino_acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc .
20172579	0	CCR5	150,154	gp120	88,93	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	interactions|nmod|START_ENTITY alter|dobj|interactions END_ENTITY|acl:relcl|alter	Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5 .
21356539	0	CCR5	80,84	gp120	132,137	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	inhibitor|compound|START_ENTITY isolate|nmod|inhibitor Resistance|nmod|isolate involve|nsubj|Resistance involve|nmod|END_ENTITY	Resistance of a human_immunodeficiency_virus_type_1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41 .
21763489	0	CCR5	49,53	gp120	94,99	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	conformation|nmod|START_ENTITY peptide|nsubj|conformation peptide|nmod|peptide peptide|amod|complex complex|nmod|END_ENTITY	The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide .
22017448	0	CCR5	26,30	gp120	106,111	CCR5	gp120	1234	3700	Gene	Gene	maraviroc|compound|START_ENTITY effects|nmod|maraviroc elicited|nsubj|effects elicited|nmod|END_ENTITY	Modulatory effects of the CCR5 antagonist maraviroc on microglial pro-inflammatory activation elicited by gp120 .
24606688	0	CCR5	38,42	gp120	106,111	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	recognition|nmod|START_ENTITY expressed|nsubj|recognition expressed|nmod|END_ENTITY	Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1 .
24763408	0	CCR5	25,29	gp120	42,47	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|loop loop|amod|END_ENTITY	Molecular recognition of CCR5 by an HIV-1 gp120 V3 loop .
25703038	0	CCR5	12,16	gp120	61,66	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	peptide|compound|START_ENTITY forms|nsubj|peptide forms|dobj|helix helix|acl:relcl|binds binds|dobj|END_ENTITY	An extended CCR5 ECL2 peptide forms a helix that binds HIV-1 gp120 through non-specific hydrophobic interactions .
25797607	0	CCR5	182,186	gp120	93,98	CCR5	gp120	1234	3700	Gene	Gene	interactions|nmod|START_ENTITY increase|nmod|interactions sheet|acl:relcl|increase sheet|amod|END_ENTITY	Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5 .
26114311	0	CCR5	110,114	gp120	88,93	CCR5	gp120	12774(Tax:10090)	3700	Gene	Gene	Loop|compound|START_ENTITY Reveal|nmod|Loop Reveal|dobj|Interactions Interactions|nmod|Crown Crown|nmod:poss|END_ENTITY	Short Communication : HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120 's V3 Crown with CCR5 Extracellular Loop 1 .
26114311	0	CCR5	51,55	gp120	88,93	CCR5	gp120	12774(Tax:10090)	3700	Gene	Gene	Reveal|compound|START_ENTITY Reveal|dobj|Interactions Interactions|nmod|Crown Crown|nmod:poss|END_ENTITY	Short Communication : HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120 's V3 Crown with CCR5 Extracellular Loop 1 .
9334377	0	CCR5	34,38	gp120	84,89	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|domains domains|nmod|binding binding|compound|END_ENTITY	Interaction of chemokine receptor CCR5 with its ligands : multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding .
9420225	0	CCR5	36,40	gp120	59,64	CCR5	gp120	1234	155971(Tax:11676)	Gene	Gene	coreceptor|compound|START_ENTITY substitutions|nmod|coreceptor impair|nsubj|substitutions impair|dobj|entry entry|amod|END_ENTITY	Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human_immunodeficiency_virus_type_1 entry .
9576954	0	CCR5	0,4	gp120	87,92	CCR5	gp120	1234	3700	Gene	Gene	utilization|nummod|START_ENTITY involves|nsubj|utilization involves|dobj|residue residue|nmod|END_ENTITY	CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV_type_1 gp120 .
24999042	0	CCR5	61,65	granzyme_B	36,46	CCR5	granzyme B	1234	3002	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|amod|END_ENTITY	HIV replication in conjunction with granzyme_B production by CCR5 + memory CD4 T cells : Implications for bystander cell and tissue pathologies .
20015219	0	CCR5	15,19	interleukin-2	116,129	CCR5	interleukin-2	1234	3558	Gene	Gene	usage|nummod|START_ENTITY Persistence|nmod|usage isolates|nsubj|Persistence isolates|nmod|individuals individuals|acl|receiving receiving|dobj|END_ENTITY	Persistence of CCR5 usage among primary human_immunodeficiency_virus isolates of individuals receiving intermittent interleukin-2 .
17627030	0	CCR5	0,4	phospholipase_D	23,38	CCR5	phospholipase D	1234	2822	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	CCR5 signaling through phospholipase_D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression .
24866282	0	CCR6	0,4	CCL20	42,47	CCR6	CCL20	12458(Tax:10090)	20297(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	CCR6 , the sole receptor for the chemokine CCL20 , promotes spontaneous intestinal tumorigenesis .
20042588	0	CCR6	22,26	CCR4	17,21	CCR6	CCR4	1235	1233	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Peripheral blood CCR4 + CCR6 + and CXCR3 + CCR6 + CD4 + T cells are highly permissive to HIV-1_infection .
21338515	0	CCR6	94,98	CCR4	89,93	CCR6	CCR4	1235	1233	Gene	Gene	imbalance|compound|START_ENTITY imbalance|compound|END_ENTITY	Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4 + CCR6 + Th/Treg cell subset imbalance in ankylosing_spondylitis .
23226545	0	CCR6	53,57	CD161	47,52	CCR6	CD161	1235	3820	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased levels of circulating IL17-producing CD161 + CCR6 + T cells are associated with graft-versus-host_disease after allogeneic stem cell transplantation .
12193700	0	CCR6	0,4	CD18	22,26	CCR6	CD18	1235	3689	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells .
15613550	0	CCR6	0,4	CD25	73,77	CCR6	CD25	1235	3559	Gene	Gene	expression|compound|START_ENTITY defines|nsubj|expression defines|nmod|CD4 CD4|compound|END_ENTITY	CCR6 expression defines regulatory effector/memory-like cells within the CD25 -LRB- + -RRB- CD4 + T-cell subset .
21400499	0	CCR6	42,46	CD25	36,40	CCR6	CD25	12458(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-22 is produced by yC-independent CD25 + CCR6 + innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality .
15774622	0	CCR6	0,4	CD4	15,18	CCR6	CD4	1235	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|nummod|END_ENTITY	CCR6 regulates CD4 + T-cell-mediated acute_graft-versus-host_disease responses .
15920150	0	CCR6	11,15	CD4	25,28	CCR6	CD4	12458(Tax:10090)	12504(Tax:10090)	Gene	Gene	Absence|nmod|START_ENTITY inhibits|nsubj|Absence inhibits|dobj|development development|compound|END_ENTITY	Absence of CCR6 inhibits CD4 + regulatory T-cell development and M-cell formation inside Peyer 's patches .
16966255	0	CCR6	0,4	CD4	59,62	CCR6	CD4	12458(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|cells cells|nummod|END_ENTITY	CCR6 regulates the function of alloreactive and regulatory CD4 + T cells during acute_graft-versus-host_disease .
18422729	0	CCR6	9,13	CD4	15,18	CCR6	CD4	1235	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Elevated CCR6 + CD4 + T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response .
18706444	0	CCR6	28,32	CD4	23,26	CCR6	CD4	12458(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Airway infiltration of CD4 + CCR6 + Th17 type cells associated with chronic cigarette smoke induced airspace enlargement .
19499521	0	CCR6	0,4	CD4	58,61	CCR6	CD4	12458(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|controlling controlling|dobj|recruitment recruitment|compound|END_ENTITY	CCR6 regulates EAE pathogenesis by controlling regulatory CD4 + T-cell recruitment to target tissues .
20629311	0	CCR6	29,33	CD4	15,18	CCR6	CD4	1235	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The change of CD4 + CD25high CCR6 + regulatory T cells in breast_cancer patients -RSB- .
21655250	0	CCR6	36,40	CD4	31,34	CCR6	CD4	12458(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In situ prior proliferation of CD4 + CCR6 + regulatory T cells facilitated by TGF-b secreting DCs is crucial for their enrichment and suppression in tumor immunity .
24223818	0	CCR6	20,24	CD4	53,56	CCR6	CD4	12458(Tax:10090)	12504(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	Chemokine receptors CCR6 and CXCR3 are necessary for CD4 -LRB- + -RRB- T cell mediated ocular_surface_disease in experimental dry_eye_disease .
26807971	0	CCR6	43,47	CD4	55,58	CCR6	CD4	1235	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4 + T-cells in HIV-infected individuals on antiretroviral therapy .
20042588	0	CCR6	38,42	CXCR3	32,37	CCR6	CXCR3	1235	2833	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Peripheral blood CCR4 + CCR6 + and CXCR3 + CCR6 + CD4 + T cells are highly permissive to HIV-1_infection .
23358848	0	CCR6	140,144	CXCR3	134,139	CCR6	CXCR3	1235	2833	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Memory_T cells in latent Mycobacterium_tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3 + CCR6 + Th1 subset .
24890729	0	CCR6	59,63	CXCR3	64,69	CCR6	CXCR3	1235	2833	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-1b promotes the differentiation of polyfunctional human CCR6 + CXCR3 + Th1/17 cells that are specific for pathogenic and commensal microbes .
26807971	0	CCR6	43,47	CXCR3	37,42	CCR6	CXCR3	1235	2833	Gene	Gene	T-cells|compound|START_ENTITY +|dobj|T-cells +|nsubj|Persistence Persistence|nmod|DNA DNA|nmod|END_ENTITY	Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4 + T-cells in HIV-infected individuals on antiretroviral therapy .
20181533	0	CCR6	14,18	Foxp3	19,24	CCR6	Foxp3	1235	50943	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Enrichment of CCR6 + Foxp3 + regulatory T cells in the tumor mass correlates with impaired CD8 + T cell function and poor prognosis of breast_cancer .
11698430	0	CCR6	14,18	IL-10	0,5	CCR6	IL-10	1235	3586	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-gamma suppress it .
18523258	0	CCR6	29,33	IL-17	14,19	CCR6	IL-17	1235	3605	Gene	Gene	memory|compound|START_ENTITY END_ENTITY|nmod|memory	Regulation of IL-17 in human CCR6 + effector memory T cells .
24890729	0	CCR6	59,63	IL-1b	0,5	CCR6	IL-1b	1235	3553	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells promotes|dobj|differentiation promotes|nsubj|END_ENTITY	IL-1b promotes the differentiation of polyfunctional human CCR6 + CXCR3 + Th1/17 cells that are specific for pathogenic and commensal microbes .
21400499	0	CCR6	42,46	IL-22	0,5	CCR6	IL-22	12458(Tax:10090)	50929(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produced|nmod|cells produced|nsubjpass|END_ENTITY	IL-22 is produced by yC-independent CD25 + CCR6 + innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality .
24385540	0	CCR6	88,92	MicroRNA-150	0,12	CCR6	MicroRNA-150	12458(Tax:10090)	387168(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6 , in advanced cutaneous_T-cell_lymphoma .
21655250	0	CCR6	36,40	TGF-b	76,81	CCR6	TGF-b	12458(Tax:10090)	21803(Tax:10090)	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ facilitated|nmod|proliferation facilitated|nmod|END_ENTITY	In situ prior proliferation of CD4 + CCR6 + regulatory T cells facilitated by TGF-b secreting DCs is crucial for their enrichment and suppression in tumor immunity .
23358848	0	CCR6	140,144	Th1	146,149	CCR6	Th1	1235	51497	Gene	Gene	subset|compound|START_ENTITY subset|amod|END_ENTITY	Memory_T cells in latent Mycobacterium_tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3 + CCR6 + Th1 subset .
9294138	0	CCR6	0,4	macrophage_inflammatory_protein_3alpha	50,88	CCR6	macrophage inflammatory protein 3alpha	1235	6364	Gene	Gene	START_ENTITY|appos|receptor receptor|acl:relcl|interacts interacts|nmod|END_ENTITY	CCR6 , a CC chemokine receptor that interacts with macrophage_inflammatory_protein_3alpha and is highly expressed in human dendritic cells .
18802075	0	CCR7	35,39	CCL19	62,67	CCR7	CCL19	1236	6363	Gene	Gene	ligation|compound|START_ENTITY ligation|nmod|END_ENTITY	Arrestin_3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21 .
19050397	0	CCR7	23,27	CCL19	36,41	CCR7	CCL19	1236	6363	Gene	Gene	levels|nmod|START_ENTITY ligands|nsubj|levels ligands|dobj|END_ENTITY	Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV_infection : correlation with viral load , disease progression and response to highly active antiretroviral therapy .
19171354	0	CCR7	62,66	CCL19	87,92	CCR7	CCL19	1236	6363	Gene	Gene	macrophages|compound|START_ENTITY invade|nsubj|macrophages invade|dobj|fibers fibers|nummod|+ +|compound|END_ENTITY	CCR7 + myeloid dendritic cells together with CCR7 + T cells and CCR7 + macrophages invade CCL19 + nonnecrotic muscle fibers in inclusion_body_myositis .
21092185	0	CCR7	79,83	CCL19	65,70	CCR7	CCL19	1236	6363	Gene	Gene	responses|compound|START_ENTITY responses|nummod|END_ENTITY	Role of the atypical chemoattractant receptor CRAM in regulating CCL19 induced CCR7 responses in B-cell_chronic_lymphocytic_leukemia .
21383953	0	CCR7	86,90	CCL19	58,63	CCR7	CCL19	1236	6363	Gene	Gene	down-regulation|nmod|START_ENTITY impairs|nmod|down-regulation impairs|dobj|migration migration|nmod|END_ENTITY	Gamma-ray irradiation impairs dendritic cell migration to CCL19 by down-regulation of CCR7 and induction of cell apoptosis .
22976543	0	CCR7	61,65	CCL19	29,34	CCR7	CCL19	1236	6363	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	The expression of chemokines CCL19 , CCL21 and their receptor CCR7 in oral_squamous_cell_carcinoma and its relevance to cervical lymph node metastasis .
24990231	0	CCR7	74,78	CCL19	39,44	CCR7	CCL19	1236	6363	Gene	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of homeostatic chemokines CCL19 and CCL21 and their receptor CCR7 to coronary_artery_disease .
26729814	0	CCR7	63,67	CCL19	92,97	CCR7	CCL19	1236	6363	Gene	Gene	pathways|nmod|START_ENTITY elicited|nsubj|pathways elicited|nmod|END_ENTITY	Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes .
25688986	0	CCR7	36,40	CCR7	80,84	CCR7	CCR7	1236	1236	Gene	Gene	Migration|compound|START_ENTITY Migration|dep|Homo Homo|compound|END_ENTITY	The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration : CCR7 Homo - and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7 .
25688986	0	CCR7	80,84	CCR7	36,40	CCR7	CCR7	1236	1236	Gene	Gene	Homo|compound|START_ENTITY Migration|dep|Homo Migration|compound|END_ENTITY	The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration : CCR7 Homo - and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7 .
25257053	0	CCR7	16,20	CD11b	21,26	CCR7	CD11b	12775(Tax:10090)	16409(Tax:10090)	Gene	Gene	homing|compound|START_ENTITY homing|compound|END_ENTITY	Dry_eye-induced CCR7 + CD11b + cell lymph_node homing is induced by COX-2 activities .
23028633	0	CCR7	8,12	CD16	79,83	CCR7	CD16	1236	2214	Gene	Gene	expression|nummod|START_ENTITY Loss|nmod|expression NK|nsubj|Loss NK|ccomp|associated associated|nmod|phenotype phenotype|compound|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
12193715	0	CCR7	125,129	CD25	25,29	CCR7	CD25	12775(Tax:10090)	16184(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY expresses|dobj|levels splenocytes|ccomp|expresses splenocytes|nsubj|subpopulation subpopulation|nmod|+ +|compound|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
17371928	0	CCR7	0,4	CD25	50,54	CCR7	CD25	12775(Tax:10090)	16184(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|nmod|cells cells|compound|END_ENTITY	CCR7 is required for the in vivo function of CD4 + CD25 + regulatory T cells .
23747721	0	CCR7	64,68	CD28	85,89	CCR7	CD28	1236	940	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD45RA-Foxp3 -LRB- high -RRB- activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28 + central memory subset are decreased in peripheral blood from patients with rheumatoid_arthritis .
10627863	0	CCR7	0,4	CD4	86,89	CCR7	CD4	1236	920	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|expression expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CCR7 -LRB- EBI1 -RRB- receptor down-regulation in asthma : differential gene expression in human CD4 + T lymphocytes .
10878344	0	CCR7	83,87	CD4	78,81	CCR7	CD4	1236	920	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Cytokines and cell surface molecules independently induce CXCR4 expression on CD4 + CCR7 + human memory T cells .
11739486	0	CCR7	36,40	CD4	88,91	CCR7	CD4	12775(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY influence|nsubj|ligand influence|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	A ligand for the chemokine receptor CCR7 can influence the homeostatic proliferation of CD4 T cells and progression of autoimmunity .
12023337	0	CCR7	76,80	CD4	42,45	CCR7	CD4	12775(Tax:10090)	12504(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY express|nmod|END_ENTITY	In vivo differentiated cytokine-producing CD4 -LRB- + -RRB- T cells express functional CCR7 .
12193715	0	CCR7	125,129	CD4	21,24	CCR7	CD4	12775(Tax:10090)	12504(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY expresses|dobj|levels splenocytes|ccomp|expresses splenocytes|nsubj|subpopulation subpopulation|nmod|+ +|compound|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
15147571	0	CCR7	14,18	CD4	125,128	CCR7	CD4	1236	920	Gene	Gene	memory|compound|START_ENTITY Aberration|nmod|memory T|nsubj|Aberration T|parataxis|helper helper|dobj|bias bias|nmod|cells cells|compound|END_ENTITY	Aberration of CCR7 CD8 memory T cells from patients with systemic_lupus_erythematosus : an inducer of T helper type 2 bias of CD4 T cells .
15743472	0	CCR7	46,50	CD4	62,65	CCR7	CD4	1236	920	Gene	Gene	+|compound|START_ENTITY characterisation|nmod|+ characterisation|dep|cells cells|nummod|END_ENTITY	Phenotypic and functional characterisation of CCR7 + and CCR7 - CD4 + memory T cells homing to the joints in juvenile_idiopathic_arthritis .
16272303	0	CCR7	72,76	CD4	28,31	CCR7	CD4	1236	920	Gene	Gene	expression|nmod|START_ENTITY defined|nmod|expression defined|nsubj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27 .
16826221	0	CCR7	92,96	CD4	27,30	CCR7	CD4	1236	920	Gene	Gene	expressing|dobj|START_ENTITY cells|dep|expressing cells|compound|END_ENTITY	A high proportion of donor CD4 + T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute_graft-versus-host_disease in patients undergoing allogeneic stem cell transplantation for hematological_malignancy .
17371928	0	CCR7	0,4	CD4	45,48	CCR7	CD4	12775(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|nmod|cells cells|compound|END_ENTITY	CCR7 is required for the in vivo function of CD4 + CD25 + regulatory T cells .
18025179	0	CCR7	0,4	CD4	58,61	CCR7	CD4	12775(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY linked|nsubjpass|expression linked|nmod|END_ENTITY	CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision .
18166500	0	CCR7	27,31	CD4	77,80	CCR7	CD4	1236	920	Gene	Gene	expression|nmod|START_ENTITY defines|nsubj|expression defines|dobj|subsets subsets|nmod|Tregs Tregs|compound|END_ENTITY	Differential expression of CCR7 defines two distinct subsets of human memory CD4 + CD25 + Tregs .
19040002	0	CCR7	11,15	CD4	72,75	CCR7	CD4	1236	920	Gene	Gene	Change|nmod|START_ENTITY lymphocytes|nsubj|Change lymphocytes|advcl|blocking blocking|nmod|channel channel|nmod|T T|compound|END_ENTITY	-LSB- Change of CCR7 and CD45RA after blocking of Kv1 .3 potassium channel of CD4 + T lymphocytes in multiple_sclerosis -RSB- .
22633193	0	CCR7	14,18	CD4	33,36	CCR7	CD4	1236	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|+ +|compound|END_ENTITY	Expression of CCR7 and CD45RA in CD4 + and CD8 + subsets in cerebrospinal fluid of 134 patients with inflammatory and non-inflammatory neurological_diseases .
22990666	0	CCR7	0,4	CD4	40,43	CCR7	CD4	1236	920	Gene	Gene	+|compound|START_ENTITY +|dep|cells cells|compound|END_ENTITY	CCR7 + central and CCR7 - effector memory CD4 + T cells in human cutaneous_leishmaniasis .
23935190	0	CCR7	0,4	CD4	64,67	CCR7	CD4	12775(Tax:10090)	12504(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|trafficking trafficking|nmod|cells cells|compound|END_ENTITY	CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes .
24566708	0	CCR7	21,25	CD4	14,17	CCR7	CD4	1236	920	Gene	Gene	T-cell|compound|START_ENTITY /|dobj|T-cell /|nsubj|END_ENTITY	Donor-derived CD4 -LRB- + -RRB- / CCR7 -LRB- + -RRB- T-cell partial selective depletion does not alter acquired anti-infective immunity .
24906571	0	CCR7	160,164	CD4	155,158	CCR7	CD4	1236	920	Gene	Gene	subsets|compound|START_ENTITY subsets|compound|END_ENTITY	-LSB- The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation : relationship between infused donor CD4 + / CCR7 + T cell subsets and acute_graft-versus-host_disease -RSB- .
25688986	0	CCR7	36,40	CD4	58,61	CCR7	CD4	1236	920	Gene	Gene	Migration|compound|START_ENTITY Migration|compound|END_ENTITY	The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration : CCR7 Homo - and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7 .
25688986	0	CCR7	80,84	CD4	58,61	CCR7	CD4	1236	920	Gene	Gene	Homo|compound|START_ENTITY Migration|dep|Homo Migration|compound|END_ENTITY	The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration : CCR7 Homo - and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7 .
23747721	0	CCR7	64,68	CD45RA-CD27	71,82	CCR7	CD45RA-CD27	1236	939	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD45RA-Foxp3 -LRB- high -RRB- activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28 + central memory subset are decreased in peripheral blood from patients with rheumatoid_arthritis .
10222066	0	CCR7	0,4	CD56	92,96	CCR7	CD56	1236	4684	Gene	Gene	ligands|nummod|START_ENTITY chemoattractants|nsubj|ligands chemoattractants|nmod|cells cells|dep|CD16 CD16|compound|END_ENTITY	CCR7 ligands , SLC/6Ckine/Exodus2 / TCA4 and CKbeta-11 / MIP-3beta / ELC , are chemoattractants for CD56 -LRB- + -RRB- CD16 -LRB- - -RRB- NK cells and late stage lymphoid progenitors .
23028633	0	CCR7	8,12	CD56	27,31	CCR7	CD56	1236	4684	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
23028633	0	CCR7	8,12	CD56	70,74	CCR7	CD56	1236	4684	Gene	Gene	expression|nummod|START_ENTITY Loss|nmod|expression NK|nsubj|Loss NK|ccomp|associated associated|nmod|phenotype phenotype|compound|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
12594271	0	CCR7	57,61	CD8	53,56	CCR7	CD8	1236	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immediate early effector functions of virus-specific CD8 + CCR7 + memory cells in humans defined by HLA and CC_chemokine_ligand_19 tetramers .
14978076	8	CCR7	1074,1078	CD8	1090,1093	CCR7	CD8	1236	925	Gene	Gene	CD62L|compound|START_ENTITY periphery|appos|CD62L seeded|nmod|periphery patrol|advcl|seeded patrol|nsubj|cells cells|compound|END_ENTITY	Once seeded in the periphery , naive CCR7 -LRB- + -RRB- CD62L -LRB- + -RRB- CD8 T cells patrol secondary lymphoid organs , whereas naive CCR7 -LRB- - -RRB- CD62L -LRB- - -RRB- CD8 T cells selectively migrate to peripheral tissues such as skin .
15147571	0	CCR7	14,18	CD8	19,22	CCR7	CD8	1236	925	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Aberration of CCR7 CD8 memory T cells from patients with systemic_lupus_erythematosus : an inducer of T helper type 2 bias of CD4 T cells .
17073944	0	CCR7	54,58	CD8	29,32	CCR7	CD8	1236	925	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Interleukin-4 promotes human CD8 T cell expression of CCR7 .
17148588	0	CCR7	58,62	CD8	34,37	CCR7	CD8	1236	925	Gene	Gene	Cartography|dep|START_ENTITY Cartography|nmod|expression expression|nmod|cells cells|nummod|END_ENTITY	Cartography of gene expression in CD8 single cells : novel CCR7 - subsets suggest differentiation independent of CD45RA expression .
17529983	0	CCR7	20,24	CD8	46,49	CCR7	CD8	1236	925	Gene	Gene	START_ENTITY|parataxis|enter enter|nsubj|cells cells|nummod|END_ENTITY	L-selectin-negative CCR7 - effector and memory CD8 + T cells enter reactive lymph nodes and kill dendritic cells .
17589293	0	CCR7	44,48	CD8	63,66	CCR7	CD8	1236	925	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|fail fail|nsubj|cells cells|nummod|END_ENTITY	Human_papillomavirus_16 E6-specific CD45RA + CCR7 + high avidity CD8 + T cells fail to control tumor growth despite interferon-gamma production in patients with cervical_cancer .
17634955	0	CCR7	38,42	CD8	34,37	CCR7	CD8	1236	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Ephrin-A1 stimulates migration of CD8 + CCR7 + T lymphocytes .
18000950	0	CCR7	7,11	CD8	13,16	CCR7	CD8	1236	925	Gene	Gene	START_ENTITY|parataxis|cells cells|nsubj|cells cells|compound|END_ENTITY	CXCR5 + CCR7 - CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles .
22821963	0	CCR7	11,15	CD8	0,3	CCR7	CD8	1236	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD45RA + CCR7 + FOXP3 + T cells with immunosuppressive properties : a novel subset of inducible human regulatory T cells .
10878344	0	CCR7	83,87	CXCR4	58,63	CCR7	IL-15	1236	3600	Gene	Gene	memory|compound|START_ENTITY expression|nmod|memory expression|nummod|END_ENTITY	Cytokines and cell surface molecules independently induce CXCR4 expression on CD4 + CCR7 + human memory T cells .
22350183	0	CCR7	49,53	CXCR4	42,47	CCR7	CXCR4	1236	7852	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Overexpression of the chemokine receptors CXCR4 , CCR7 , CCR9 , and CCR10 in human primary cutaneous_melanoma : a potential prognostic value for CCR7 and CCR10 ?
22718198	0	CCR7	30,34	Cyclooxygenase-2	0,16	CCR7	Cyclooxygenase-2	1236	5743	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast_cancer cells .
10627863	0	CCR7	0,4	EBI1	6,10	CCR7	EBI1	1236	1236	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	CCR7 -LRB- EBI1 -RRB- receptor down-regulation in asthma : differential gene expression in human CD4 + T lymphocytes .
10222066	0	CCR7	0,4	ELC	62,65	CCR7	ELC	1236	6363	Gene	Gene	ligands|nummod|START_ENTITY ligands|appos|END_ENTITY	CCR7 ligands , SLC/6Ckine/Exodus2 / TCA4 and CKbeta-11 / MIP-3beta / ELC , are chemoattractants for CD56 -LRB- + -RRB- CD16 -LRB- - -RRB- NK cells and late stage lymphoid progenitors .
22821963	0	CCR7	11,15	FOXP3	16,21	CCR7	FOXP3	1236	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD45RA + CCR7 + FOXP3 + T cells with immunosuppressive properties : a novel subset of inducible human regulatory T cells .
17698914	0	CCR7	0,4	Foxp3	31,36	CCR7	Foxp3	12775(Tax:10090)	20371(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|migration migration|nmod|cells cells|amod|END_ENTITY	CCR7 mediates the migration of Foxp3 + regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules .
18724230	0	CCR7	56,60	Foxp3	102,107	CCR7	Foxp3	1236	50943	Gene	Gene	absence|nmod|START_ENTITY transplant_arteriosclerosis|nmod|absence associated|nsubjpass|transplant_arteriosclerosis associated|nmod|expression expression|nmod|END_ENTITY	Increased transplant_arteriosclerosis in the absence of CCR7 is associated with reduced expression of Foxp3 .
22067914	0	CCR7	0,4	Foxp3	55,60	CCR7	Foxp3	12775(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nmod|S1P1 S1P1|acl|signaling signaling|nmod|AP-1 AP-1|nmod|migration migration|nmod|T-cells T-cells|amod|END_ENTITY	CCR7 with S1P1 signaling through AP-1 for migration of Foxp3 + regulatory T-cells controls autoimmune exocrinopathy .
26832402	0	CCR7	0,4	Foxp3	74,79	CCR7	Foxp3	12775(Tax:10090)	20371(Tax:10090)	Gene	Gene	Recirculation|compound|START_ENTITY Recirculation|nmod|T T|compound|END_ENTITY	CCR7 Controls Thymus Recirculation , but Not Production and Emigration , of Foxp3 -LRB- + -RRB- T Cells .
19305150	0	CCR7	16,20	HIF-1alpha	36,46	CCR7	HIF-1alpha	1236	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung_cancer cells .
20738921	0	CCR7	40,44	HIF-1alpha	59,69	CCR7	HIF-1alpha	1236	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- Upregulation of the Chemokine Receptor CCR7 expression by HIF-1alpha and HIF-2alpha in non-small_cell_lung_cancer . -RSB- .
26231034	0	CCR7	12,16	ICOS	17,21	CCR7	ICOS	1236	29851	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Circulating CCR7 + ICOS + Memory T Follicular Helper Cells in Patients with Multiple_Sclerosis .
17073944	0	CCR7	54,58	Interleukin-4	0,13	CCR7	Interleukin-4	1236	3565	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Interleukin-4 promotes human CD8 T cell expression of CCR7 .
12193715	0	CCR7	125,129	L-selectin	95,105	CCR7	L-selectin	12775(Tax:10090)	20343(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
18606672	0	CCR7	16,20	SOCS1	0,5	CCR7	SOCS1	12775(Tax:10090)	12703(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SOCS1 regulates CCR7 expression and migration of CD4 + T cells into peripheral tissues .
9507024	0	CCR7	89,93	Secondary_lymphoid-tissue_chemokine	0,35	CCR7	Secondary lymphoid-tissue chemokine	1236	6366	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Secondary_lymphoid-tissue_chemokine is a functional ligand for the CC chemokine receptor CCR7 .
26923638	0	CCR7	55,59	Siglec-9	25,33	CCR7	Siglec-9	1236	27180	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Constitutively expressed Siglec-9 inhibits LPS-induced CCR7 , but enhances IL-4-induced CD200R expression in human macrophages .
22718198	0	CCR7	30,34	Sp1	97,100	CCR7	Sp1	1236	6667	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast_cancer cells .
15304089	0	CCR7	23,27	TNF-alpha	111,120	CCR7	TNF-alpha	1236	7124	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways : role of TNF-alpha and MAPK .
23939705	0	CCR7	115,119	VEGFR-3	107,114	CCR7	VEGFR-3	1236	2324	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Hypoxia preconditioning of mesenchymal stromal cells enhances PC3 cell lymphatic metastasis accompanied by VEGFR-3 / CCR7 activation .
15991182	0	CCR7	77,81	cysteine_receptor_7	56,75	CCR7	cysteine receptor 7	12775(Tax:10090)	12775(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Murine neuroblastoma attenuates dendritic cell cysteine cysteine_receptor_7 -LRB- CCR7 -RRB- expression .
15040017	0	CCR7	74,78	vascular_endothelial_growth_factor_C	14,50	CCR7	vascular endothelial growth factor C	1236	7424	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of vascular_endothelial_growth_factor_C and chemokine receptor CCR7 in gastric_carcinoma and their values in predicting lymph_node_metastasis .
15699124	0	CCR8	0,4	CD25	59,63	CCR8	CD25	12776(Tax:10090)	16184(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	CCR8 is expressed by antigen-elicited , IL-10-producing CD4 + CD25 + T cells , which regulate Th2-mediated granuloma formation in mice .
15699124	0	CCR8	0,4	CD4	55,58	CCR8	CD4	12776(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	CCR8 is expressed by antigen-elicited , IL-10-producing CD4 + CD25 + T cells , which regulate Th2-mediated granuloma formation in mice .
17082609	0	CCR8	0,4	CD4	27,30	CCR8	CD4	1237	920	Gene	Gene	expression|compound|START_ENTITY identifies|nsubj|expression identifies|dobj|cells cells|nummod|END_ENTITY	CCR8 expression identifies CD4 memory T cells enriched for FOXP3 + regulatory and Th2 effector lymphocytes .
17082609	8	CCR8	993,997	CD4	998,1001	CCR8	CD4	12776(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Two-thirds of CCR8 + CD4 T cells express cutaneous lymphocyte-associated Ag while the majority lack gut-homing receptors .
17947648	0	CCR8	116,120	CD4	56,59	CCR8	CD4	1237	920	Gene	Gene	involvement|nmod|START_ENTITY evidence|nmod|involvement Recruitment|dep|evidence Recruitment|nmod|macrophages macrophages|nmod|cells cells|compound|END_ENTITY	Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes : evidence for involvement of CCR8 and CCL1 .
25390351	0	CCR8	43,47	Chemokine_Receptor	18,36	CCR8	Chemokine Receptor	1237	7852	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|Gene Gene|compound|END_ENTITY	Expression of the Chemokine_Receptor Gene , CCR8 , is Associated With DUSP22 Rearrangements in Anaplastic_Large_Cell_Lymphoma .
9469461	0	CCR8	18,22	I-309	77,82	CCR8	I-309	1237	6346	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	Identification of CCR8 as the specific receptor for the human beta-chemokine I-309 : cloning and molecular characterization of murine CCR8 as the receptor for TCA-3 .
9469461	0	CCR8	133,137	TCA-3	158,163	CCR8	TCA-3	12776(Tax:10090)	20290(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	Identification of CCR8 as the specific receptor for the human beta-chemokine I-309 : cloning and molecular characterization of murine CCR8 as the receptor for TCA-3 .
9670926	0	CCR8	23,27	Th2	59,62	CCR8	Th2	1237	15111(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells .
11751956	0	CCR9	20,24	CCL25	197,202	CCR9	CCL25	12769(Tax:10090)	20300(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Characterization|nmod|expression _|nsubj|Characterization _|parataxis|CD69 CD69|ccomp|respond respond|nmod|END_ENTITY	Characterization of CCR9 expression and CCL25/thymus-expressed _ chemokine responsiveness during T cell development : CD3 -LRB- high -RRB- CD69 + thymocytes and gammadeltaTCR + thymocytes preferentially respond to CCL25 .
12096027	0	CCR9	29,33	CCL25	16,21	CCR9	CCL25	12769(Tax:10090)	20300(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Pivotal role of CCL25 -LRB- TECK -RRB- - CCR9 in the formation of gut cryptopatches and consequent appearance of intestinal intraepithelial T lymphocytes .
15557349	0	CCR9	54,58	CCL25	20,25	CCR9	CCL25	10803	6370	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ recruitment|nmod|lymphocytes mediates|dobj|recruitment mediates|nsubj|END_ENTITY	Hepatic endothelial CCL25 mediates the recruitment of CCR9 + gut-homing lymphocytes to the liver in primary sclerosing cholangitis .
20504763	0	CCR9	98,102	CCL25	125,130	CCR9	CCL25	12769(Tax:10090)	20300(Tax:10090)	Gene	Gene	down-regulates|dep|START_ENTITY down-regulates|appos|END_ENTITY	Angiotensin-converting_enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 -LRB- CCR9 -RRB- - chemokine ligand 25 -LRB- CCL25 -RRB- axis .
21295855	0	CCR9	20,24	CCL25	79,84	CCR9	CCL25	10803	6370	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	Specific killing of CCR9 high-expressing acute T_lymphocytic_leukemia cells by CCL25 fused with PE38 toxin .
14559839	0	CCR9	69,73	CD4	77,80	CCR9	CD4	10803	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Selectively increased expression and functions of chemokine receptor CCR9 on CD4 + T cells from patients with T-cell_lineage_acute_lymphocytic_leukemia .
18453568	0	CCR9	14,18	CD4	22,25	CCR9	CD4	12769(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells .
26616645	0	CCR9	0,4	CD4	36,39	CCR9	CD4	10803	920	Gene	Gene	thymocytes|nsubj|START_ENTITY thymocytes|amod|over-expressed over-expressed|nmod|CD8 CD8|compound|END_ENTITY	CCR9 and CCR7 are over-expressed in CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes of myasthenia_gravis patients .
22197009	0	CCR9	24,28	Interleukin_4	0,13	CCR9	Interleukin 4	428454(Tax:9031)	416330(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin_4 increases CCR9 expression and homing of lymphocytes to gut-associated lymphoid tissue in chickens .
10498628	0	CCR9	72,76	TECK	0,4	CCR9	TECK	10803	6370	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	TECK , an efficacious chemoattractant for human thymocytes , uses GPR-9-6 / CCR9 as a specific receptor .
26003048	0	CCR9	72,76	b-catenin	32,41	CCR9	b-catenin	10803	1499	Gene	Gene	antagonist|compound|START_ENTITY END_ENTITY|nmod|antagonist	CCR9-mediated signaling through b-catenin and identification of a novel CCR9 antagonist .
10229797	0	CCR9	73,77	chemokine_TECK	100,114	CCR9	chemokine TECK	10803	6370	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Cutting edge : identification of the orphan chemokine receptor GPR-9-6 as CCR9 , the receptor for the chemokine_TECK .
10623805	0	CCR9	7,11	thymus-expressed_chemokine	38,64	CCR9	thymus-expressed chemokine	12769(Tax:10090)	20300(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Murine CCR9 , a chemokine receptor for thymus-expressed_chemokine that is up-regulated following pre-TCR signaling .
11046037	0	CCR9	56,60	thymus-expressed_chemokine	12,38	CCR9	thymus-expressed chemokine	10803	6370	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of thymus-expressed_chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system .
26699909	0	CCRL1	66,71	CCX-CKR	57,64	CCRL1	CCX-CKR	51554	51554	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Endogenous expression of the atypical chemokine receptor CCX-CKR -LRB- CCRL1 -RRB- gene in human embryonic kidney -LRB- HEK 293 -RRB- cells .
18794339	0	CCRL2	36,41	chemerin	48,56	CCRL2	chemerin	54199(Tax:10090)	71660(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis .
18794339	0	CCRL2	36,41	chemerin	48,56	CCRL2	chemerin	54199(Tax:10090)	71660(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis .
22696441	0	CCRL2	67,72	chemerin	49,57	CCRL2	chemerin	54199(Tax:10090)	71660(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression , regulation , and function of atypical chemerin receptor CCRL2 on endothelial cells .
8071346	0	CCSP	196,200	Clara_cell_secretory_protein	166,194	CCSP	Clara cell secretory protein	7356	7356	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Two members of the HNF-3 family have opposite effects on a lung transcriptional element ; HNF-3_alpha stimulates and HNF-3_beta inhibits activity of region I from the Clara_cell_secretory_protein -LRB- CCSP -RRB- promoter .
12388333	0	CCSP	30,34	interferon-gamma	38,54	CCSP	interferon-gamma	22287(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of CCSP by interferon-gamma in vitro and in vivo .
20018251	0	CCT	62,65	BAG3	17,21	CCT	BAG3	907	9531	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	The co-chaperone BAG3 interacts with the cytosolic chaperonin CCT : new hints for actin folding .
24854858	0	CCT	33,36	chaperonin	22,32	CCT	chaperonin	21454(Tax:10090)	432551(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Essential role of the chaperonin CCT in rod outer segment biogenesis .
21529916	0	CCT8	23,27	CRISP2	15,21	CCT8	CRISP2	281047(Tax:9913)	512443(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Association of CRISP2 , CCT8 , PEBP1 mRNA abundance in sperm and sire_conception_rate in Holstein bulls .
21529916	0	CCT8	23,27	PEBP1	29,34	CCT8	PEBP1	281047(Tax:9913)	618233(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	Association of CRISP2 , CCT8 , PEBP1 mRNA abundance in sperm and sire_conception_rate in Holstein bulls .
8901050	0	CCT_gamma	34,43	chaperonin	47,57	CCT gamma	chaperonin	380506(Tax:8355)	399217(Tax:8355)	Gene	Gene	START_ENTITY|appos|subunit subunit|compound|END_ENTITY	Cloning and expression of Xenopus CCT_gamma , a chaperonin subunit developmentally regulated in neural-derived and myogenic lineages .
26699909	0	CCX-CKR	57,64	CCRL1	66,71	CCX-CKR	CCRL1	51554	51554	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Endogenous expression of the atypical chemokine receptor CCX-CKR -LRB- CCRL1 -RRB- gene in human embryonic kidney -LRB- HEK 293 -RRB- cells .
11981810	0	CCX-CKR	153,160	mCCL19	125,131	CCX-CKR	mCCL19	51554	24047(Tax:10090)	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Characterization of mouse CCX-CKR , a receptor for the lymphocyte-attracting chemokines TECK/mCCL25 , SLC/mCCL21 and MIP-3beta / mCCL19 : comparison to human CCX-CKR .
11981810	0	CCX-CKR	26,33	mCCL19	125,131	CCX-CKR	mCCL19	252837(Tax:10090)	24047(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|END_ENTITY	Characterization of mouse CCX-CKR , a receptor for the lymphocyte-attracting chemokines TECK/mCCL25 , SLC/mCCL21 and MIP-3beta / mCCL19 : comparison to human CCX-CKR .
8658171	0	CC_CKR5	0,7	MIP-1beta	31,40	CC CKR5	MIP-1beta	1234	6351	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	CC_CKR5 : a RANTES , MIP-1alpha , MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 .
8658171	0	CC_CKR5	0,7	RANTES	11,17	CC CKR5	RANTES	1234	6352	Gene	Gene	START_ENTITY|dep|receptor receptor|compound|END_ENTITY	CC_CKR5 : a RANTES , MIP-1alpha , MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 .
17893273	0	CC_chemokine_ligand-5	33,54	CCL5	56,60	CC chemokine ligand-5	CCL5	20304(Tax:10090)	20304(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Y-box_binding_protein-1 controls CC_chemokine_ligand-5 -LRB- CCL5 -RRB- expression in smooth muscle cells and contributes to neointima_formation in atherosclerosis-prone mice .
15784687	0	CC_chemokine_ligand_18	15,37	CCL18	39,44	CC chemokine ligand 18	CCL18	6362	6362	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of CC_chemokine_ligand_18 -LRB- CCL18 -RRB- in normal and pathological processes .
17379849	0	CC_chemokine_ligand_2	4,25	IL-6	70,74	CC chemokine ligand 2	IL-6	6347	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	The CC_chemokine_ligand_2 -LRB- CCL2 -RRB- mediates fibroblast survival through IL-6 .
15327893	0	CC_chemokine_ligand_3	4,25	CD8alpha	48,56	CC chemokine ligand 3	CD8alpha	20302(Tax:10090)	12525(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The CC_chemokine_ligand_3 regulates CD11c + CD11b + CD8alpha - dendritic cell maturation and activation following viral_infection_of_the_central_nervous_system : implications for a role in T cell activation .
21827290	0	CC_chemokine_receptor	39,60	CCR5	62,66	CC chemokine receptor	CCR5	1234	1234	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Analysis of peripheral T cells and the CC_chemokine_receptor -LRB- CCR5 -RRB- delta32 polymorphism in prostate_cancer patients treated with carboxymethyl-glucan -LRB- CM-G -RRB- .
15664858	0	CC_chemokine_receptor-3	42,65	CCR3	67,71	CC chemokine receptor-3	CCR3	1232	1232	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	N-Arylalkylpiperidine_urea derivatives as CC_chemokine_receptor-3 -LRB- CCR3 -RRB- antagonists .
15771462	0	CC_chemokine_receptor-3	13,36	CCR3	38,42	CC chemokine receptor-3	CCR3	12771(Tax:10090)	12771(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of CC_chemokine_receptor-3 -LRB- CCR3 -RRB- antagonists with picomolar potency .
18722120	0	CC_chemokine_receptor_2	72,95	CCR2	97,101	CC chemokine receptor 2	CCR2	729230	729230	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and evaluation of cis-3 ,4 - disubstituted_piperidines as potent CC_chemokine_receptor_2 -LRB- CCR2 -RRB- antagonists .
19481449	0	CC_chemokine_receptor_2	71,94	CCR2	96,100	CC chemokine receptor 2	CCR2	729230	729230	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel sulfone-containing di - _ and_trisubstituted_cyclohexanes as potent CC_chemokine_receptor_2 -LRB- CCR2 -RRB- antagonists .
21247529	0	CC_chemokine_receptor_2	10,33	CCR2	34,38	CC chemokine receptor 2	CCR2	729230	729230	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of CC_chemokine_receptor_2 CCR2 blockade on serum C-reactive_protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte_chemoattractant_protein-1 promoter region .
18587271	0	CC_chemokine_receptor_2	28,51	LZIP	6,10	CC chemokine receptor 2	LZIP	729230	10488	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Human LZIP induces monocyte CC_chemokine_receptor_2 expression leading to enhancement of monocyte_chemoattractant_protein_1 / CCL2-induced cell migration .
16931001	0	CC_chemokine_receptor_3	43,66	CCR3	68,72	CC chemokine receptor 3	CCR3	1232	1232	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	2,4-Disubstituted _ piperidines as selective CC_chemokine_receptor_3 -LRB- CCR3 -RRB- antagonists : synthesis and selectivity .
12871220	0	CC_chemokine_receptor_3	32,55	CD34	82,86	CC chemokine receptor 3	CD34	1232	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Allergen-induced fluctuation in CC_chemokine_receptor_3 expression on bone marrow CD34 + cells from asthmatic subjects : significance for mobilization of haemopoietic progenitor cells in allergic_inflammation .
10085131	0	CC_chemokine_receptor_5	41,64	CCR5	66,70	CC chemokine receptor 5	CCR5	117029(Tax:10116)	117029(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Differential effects of CC chemokines on CC_chemokine_receptor_5 -LRB- CCR5 -RRB- phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus .
11354628	0	CC_chemokine_receptor_5	16,39	CCR5	41,45	CC chemokine receptor 5	CCR5	1234	1234	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Analysis of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- delta-32 polymorphism in inflammatory_bowel_disease .
11803051	0	CC_chemokine_receptor_5	0,23	CCR5	25,29	CC chemokine receptor 5	CCR5	1234	1234	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	CC_chemokine_receptor_5 -LRB- CCR5 -RRB- mRNA expression in pulmonary_sarcoidosis .
12403770	0	CC_chemokine_receptor_5	30,53	CCR5	55,59	CC chemokine receptor 5	CCR5	1234	1234	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of ligand-stimulated CC_chemokine_receptor_5 -LRB- CCR5 -RRB- phosphorylation in intact cells using phosphosite-specific antibodies .
12919745	0	CC_chemokine_receptor_5	27,50	CCR5	52,56	CC chemokine receptor 5	CCR5	12774(Tax:10090)	12774(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Functional analysis of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- on virus-specific CD8 + T cells following coronavirus infection_of_the_central_nervous_system .
15009175	0	CC_chemokine_receptor_5	16,39	CCR5	41,45	CC chemokine receptor 5	CCR5	1234	1234	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Analysis of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- Delta32 polymorphism in Beh et 's disease .
15787642	0	CC_chemokine_receptor_5	102,125	CCR5	127,131	CC chemokine receptor 5	CCR5	1234	1234	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Distribution of human chemokine _ -LRB- C-X3-C -RRB- _ receptor_1 -LRB- CX3CR1 -RRB- gene polymorphisms and haplotypes of the CC_chemokine_receptor_5 -LRB- CCR5 -RRB- promoter in Chinese people , and the effects of CCR5 haplotypes on CCR5 expression .
11930315	0	CC_chemokine_receptor_5	76,99	CD4	56,59	CC chemokine receptor 5	CD4	1234	920	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	Response to treatment and disease progression linked to CD4 + T cell surface CC_chemokine_receptor_5 density in human_immunodeficiency_virus_type_1_vertical_infection .
25201147	0	CC_chemokine_receptor_6	23,46	Interleukin-17	0,14	CC chemokine receptor 6	Interleukin-17	1235	3605	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-17 induces CC_chemokine_receptor_6 expression and cell migration in colorectal_cancer cells .
15220427	0	CC_chemokine_receptor_7	0,23	CD4	54,57	CC chemokine receptor 7	CD4	1236	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CC_chemokine_receptor_7 expression by effector/memory CD4 + T cells depends on antigen specificity and tissue localization during influenza_A_virus infection .
9570558	0	CC_chemokine_receptors_1_and_3	0,30	IL-5	63,67	CC chemokine receptors 1 and 3	IL-5	1232	3567	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	CC_chemokine_receptors_1_and_3 are differentially regulated by IL-5 during maturation of eosinophilic HL-60 cells .
15039444	0	CC_chemokine_receptors_1_and_5	44,74	CCL26	10,15	CC chemokine receptors 1 and 5	CCL26	1234	10344	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Eotaxin-3 / CCL26 is a natural antagonist for CC_chemokine_receptors_1_and_5 .
16034306	0	CD-117	44,50	c-kit	37,42	CD-117	c-kit	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	An immunohistochemical evaluation of c-kit -LRB- CD-117 -RRB- expression in malignant_melanoma , and results of imatinib_mesylate -LRB- Gleevec -RRB- therapy in three patients .
15288834	0	CD-34_and_factor-8	29,47	TIMP-1	21,27	CD-34 and factor-8	TIMP-1	947	7076	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of MMP-9 , TIMP-1 , CD-34_and_factor-8 as prognostic markers for squamous_cell_carcinoma_of_the_tongue .
7679530	0	CD-54	56,61	ICAM-1	48,54	CD-54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The modulation of human aortic endothelial cell ICAM-1 -LRB- CD-54 -RRB- expression by serum containing high titers of anti-HLA antibodies .
7593605	0	CD-80	25,30	CD-86	42,47	CD-80	CD-86	941	942	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Distinct roles for B7-1 -LRB- CD-80 -RRB- and B7-2 -LRB- CD-86 -RRB- in the initiation of experimental_allergic_encephalomyelitis .
7593605	0	CD-86	42,47	CD-80	25,30	CD-86	CD-80	942	941	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Distinct roles for B7-1 -LRB- CD-80 -RRB- and B7-2 -LRB- CD-86 -RRB- in the initiation of experimental_allergic_encephalomyelitis .
17977671	0	CD-RAP	115,121	MIA	153,156	CD-RAP	MIA	8190	100064799(Tax:9796)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Molecular characterization and chromosomal assignment of equine cartilage derived retinoic_acid sensitive protein -LRB- CD-RAP -RRB- / melanoma_inhibitory_activity -LRB- MIA -RRB- .
12358374	0	CD-RAP	63,69	cartilage-derived_retinoic-acid-sensitive_protein	12,61	CD-RAP	cartilage-derived retinoic-acid-sensitive protein	8190	8190	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of cartilage-derived_retinoic-acid-sensitive_protein -LRB- CD-RAP -RRB- in synovial fluid from patients with osteoarthritis and rheumatoid_arthritis .
11918321	0	CD-RAP	57,63	cartilage-derived_retinoic_acid-sensitive_protein	6,55	CD-RAP	cartilage-derived retinoic acid-sensitive protein	81510(Tax:10116)	81510(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum cartilage-derived_retinoic_acid-sensitive_protein -LRB- CD-RAP -RRB- levels in swarm rat chondrosarcoma .
22123310	0	CD-RAP	83,89	cartilage-derived_retinoic_acid-sensitive_protein	32,81	CD-RAP	cartilage-derived retinoic acid-sensitive protein	12587(Tax:10090)	12587(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Immunohistochemical analysis of cartilage-derived_retinoic_acid-sensitive_protein -LRB- CD-RAP -RRB- / melanoma_inhibitory_activity -LRB- MIA -RRB- in murine , canine , bovine and equine cerebrospinal tissues .
1375001	0	CD1	112,115	CD4	100,103	CD1	CD4	911	920	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
1375001	0	CD1	112,115	CD7	94,97	CD1	CD7	911	924	Gene	Gene	-|compound|START_ENTITY +|appos|- +|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
1375001	0	CD1	112,115	CD8	106,109	CD1	CD8	911	925	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
15579430	0	CD1	50,53	IL-10	29,34	CD1	IL-10	910	3586	Gene	Gene	molecules|compound|START_ENTITY molecules|compound|END_ENTITY	Metastatic_melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic_tumor lesions .
3275721	0	CD1	22,25	Interleukin_1	0,13	CD1	Interleukin 1	911	3552	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_1 induces CD1 antigen expression on human gingival epithelial cells .
7691652	0	CD1	63,66	S100	0,4	CD1	S100	911	6271	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	S100 protein and neuron-specific_enolase on monocytic leukemic CD1 + cells , probable precursors of Langerhans cells .
23052175	0	CD10	80,84	Bcl-6	86,91	CD10	Bcl-6	4311	604	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	A unique case of blastoid variant of mantle_cell_lymphoma with an aberrant CD5 - / CD10 + / Bcl-6 + / CD56 + immunophenotype : a case report .
12886247	0	CD10	131,135	CD15	156,160	CD10	CD15	24590(Tax:10116)	2526	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Expression of the human homologue of rat NG2 in adult acute_lymphoblastic_leukemia : close association with MLL rearrangement and a CD10 -LRB- - -RRB- / CD24 -LRB- - -RRB- / CD65s -LRB- + -RRB- / CD15 -LRB- + -RRB- B-cell phenotype .
9477126	0	CD10	31,35	CD19	36,40	CD10	CD19	4311	930	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Prognostic significance of the CD10 + CD19 + CD34 + B-progenitor immunophenotype in children with acute_lymphoblastic_leukemia : a report from the Children 's Cancer Group .
16753590	0	CD10	13,17	CD20	8,12	CD10	CD20	4311	54474	Gene	Gene	T-cell_lymphoma|compound|START_ENTITY +|dobj|T-cell_lymphoma +|nsubj|END_ENTITY	Primary CD20 + CD10 + CD8 + T-cell_lymphoma of the skin with IgH and TCR_beta gene rearrangement .
12886247	0	CD10	131,135	CD24	139,143	CD10	CD24	24590(Tax:10116)	25145(Tax:10116)	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Expression of the human homologue of rat NG2 in adult acute_lymphoblastic_leukemia : close association with MLL rearrangement and a CD10 -LRB- - -RRB- / CD24 -LRB- - -RRB- / CD65s -LRB- + -RRB- / CD15 -LRB- + -RRB- B-cell phenotype .
1531306	0	CD10	180,184	CD24	155,159	CD10	CD24	4311	100133941	Gene	Gene	BA-1|dep|START_ENTITY BA-1|dep|END_ENTITY	Autologous bone marrow transplantation in high-risk remission B-lineage acute_lymphoblastic_leukemia using a cocktail of three monoclonal antibodies -LRB- BA-1 / CD24 , BA-2 / CD9 , and BA-3 / CD10 -RRB- plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging .
24492332	0	CD10	18,22	CD34	24,28	CD10	CD34	4311	947	Gene	Gene	CD117|dep|START_ENTITY CD117|dep|END_ENTITY	Utility of Ki-67 , CD10 , CD34 , p53 , CD117 , and mast cell content in the differential diagnosis of cellular fibroadenomas and in the classification of phyllodes tumors of the breast .
9477126	0	CD10	31,35	CD34	41,45	CD10	CD34	4311	947	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Prognostic significance of the CD10 + CD19 + CD34 + B-progenitor immunophenotype in children with acute_lymphoblastic_leukemia : a report from the Children 's Cancer Group .
10482997	0	CD10	93,97	CD5	83,86	CD10	CD5	4311	921	Gene	Gene	+|compound|START_ENTITY groups|nummod|+ END_ENTITY|nmod|groups	Molecular and immunological dissection of diffuse large B_cell_lymphoma : CD5 + , and CD5 - with CD10 + groups may constitute clinically relevant subtypes .
11925876	0	CD10	6,10	CD5	1,4	CD10	CD5	4311	921	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- CD5 + CD10 + extranodal B-cell_lymphoma with tetraploid_chromosomal_abnormality -RSB- .
15272540	0	CD10	122,126	CD5	91,94	CD10	CD5	4311	921	Gene	Gene	case|nmod|START_ENTITY case|nmod|loss loss|nmod|expression expression|compound|END_ENTITY	An unusual case of leukemic mantle_cell_lymphoma with a blastoid_component showing loss of CD5 and aberrant expression of CD10 .
17875529	0	CD10	39,43	CD5	35,38	CD10	CD5	4311	921	Gene	Gene	B-cell_lymphoma|compound|START_ENTITY B-cell_lymphoma|compound|END_ENTITY	t -LRB- 6 ; 14 -RRB- -LRB- q15 ; q32 -RRB- in a patient with CD5 + CD10 + diffuse large B-cell_lymphoma .
18684040	0	CD10	60,64	CD5	55,58	CD10	CD5	4311	921	Gene	Gene	+|compound|START_ENTITY case|parataxis|+ case|nmod|END_ENTITY	A unique case of mantle_cell_lymphoma with an aberrant CD5 - / CD10 + immunophenotype and typical morphology .
20379114	0	CD10	39,43	CD5	34,37	CD10	CD5	4311	921	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Marfan_syndrome complicated with CD5 + CD10 + diffuse_large_B-cell_lymphoma -RSB- .
23052175	0	CD10	80,84	CD5	75,78	CD10	CD5	4311	921	Gene	Gene	+|compound|START_ENTITY case|parataxis|+ case|nmod|END_ENTITY	A unique case of blastoid variant of mantle_cell_lymphoma with an aberrant CD5 - / CD10 + / Bcl-6 + / CD56 + immunophenotype : a case report .
23289620	0	CD10	55,59	CD9	20,23	CD10	CD9	4311	928	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes .
17342744	0	CD10	30,34	HSP27	0,5	CD10	HSP27	4311	3315	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	HSP27 and HSP70 interact with CD10 in C4-2 prostate_cancer cells .
20947507	0	CD10	61,65	NF-kappaB	0,9	CD10	NF-kappaB	4311	4790	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155 / PU .1 pathway .
12800208	0	CD10	121,125	bcl-6	20,25	CD10	bcl-6	4311	604	Gene	Gene	large_B-cell_lymphomas|nummod|START_ENTITY subset|nmod|large_B-cell_lymphomas identification|nmod|subset value|dep|identification value|nmod|immunoreactivity immunoreactivity|compound|END_ENTITY	Prognostic value of bcl-6 , CD10 and CD38 immunoreactivity in stage I-II gastric_lymphomas : identification of a subset of CD10 + large_B-cell_lymphomas with a favorable outcome .
24492332	0	CD10	18,22	p53	30,33	CD10	p53	4311	7157	Gene	Gene	CD117|dep|START_ENTITY CD117|dep|END_ENTITY	Utility of Ki-67 , CD10 , CD34 , p53 , CD117 , and mast cell content in the differential diagnosis of cellular fibroadenomas and in the classification of phyllodes tumors of the breast .
8955171	0	CD100	0,5	CD45	25,29	CD100	CD45	10507	5788	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	CD100 is associated with CD45 at the surface of human T lymphocytes .
22664873	0	CD103	80,85	CCR5	26,30	CD103	CCR5	16407(Tax:10090)	12774(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103 + effector/memory regulatory T cells .
22306017	0	CD103	40,45	CD11b	48,53	CD103	CD11b	16407(Tax:10090)	16409(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nsubj|production	Interleukin 23 production by intestinal CD103 -LRB- + -RRB- CD11b -LRB- + -RRB- dendritic cells in response to bacterial_flagellin_enhances_mucosal_innate_immune_defense .
22474352	0	CD103	61,66	CD11b	68,73	CD103	CD11b	16407(Tax:10090)	16409(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY populations|compound|END_ENTITY	Viral-induced encephalitis initiates distinct and functional CD103 + CD11b + brain dendritic cell populations within the olfactory bulb .
16116203	0	CD103	88,93	CD4	84,87	CD103	CD4	16407(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4 + CD103 + regulatory T cells in vivo .
17513734	0	CD103	0,5	CD4	127,130	CD103	CD4	16407(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY specialized|nsubj|cells specialized|advcl|presenting presenting|nmod|+ +|compound|END_ENTITY	CD103 - and CD103 + bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4 + and CD8 + T cells .
18550852	0	CD103	18,23	CD4	24,27	CD103	CD4	3682	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vivo-activated CD103 + CD4 + regulatory T cells ameliorate ongoing chronic_graft-versus-host_disease .
19553521	0	CD103	15,20	CD4	35,38	CD103	CD4	16407(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	IL-2 regulates CD103 expression on CD4 + T cells in Scurfy mice that display both CD103-dependent and independent inflammation .
20599216	0	CD103	51,56	CD4	13,16	CD103	CD4	16407(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY T|nmod|depletion T|nsubj|Induction Induction|nmod|CD25 CD25|compound|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells with CD103 depletion .
20824715	0	CD103	27,32	CD4	15,18	CD103	CD4	3682	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tumor-reactive CD4 + CD8ab + CD103 + abT cells : a prevalent tumor-reactive T-cell subset in metastatic colorectal_cancers .
21908266	0	CD103	11,16	CD4	79,82	CD103	CD4	16407(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induce|nsubj|+ induce|dobj|responses responses|compound|END_ENTITY	Mouse lung CD103 + and CD11bhigh dendritic cells preferentially induce distinct CD4 + T-cell responses .
23733880	0	CD103	78,83	CD4	149,152	CD103	CD4	16407(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY dehydrogenase|nmod|+ cells|amod|dehydrogenase retinaldehyde|dobj|cells retinaldehyde|advcl|induce induce|dobj|novo novo|nmod|cells cells|compound|END_ENTITY	Cutting edge : inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103 + but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4 + T cells and promote airway tolerance .
25308332	0	CD103	37,42	CD4	0,3	CD103	CD4	3682	920	Gene	Gene	T|compound|START_ENTITY formation|nmod|T T|dep|formation T|compound|END_ENTITY	CD4 + T cell help guides formation of CD103 + lung-resident memory CD8 + T cells during influenza viral_infection .
12511714	0	CD103	121,126	CD69	115,119	CD103	CD69	3682	969	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Sputum T lymphocytes in asthma , COPD and healthy subjects have the phenotype of activated intraepithelial T cells -LRB- CD69 + CD103 + -RRB- .
10385079	0	CD103	53,58	CD8	69,72	CD103	CD8	3682	925	Gene	Gene	integrin|appos|START_ENTITY Regulation|nmod|integrin Regulation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Regulation of the epithelial cell-specific integrin , CD103 , by human CD8 + cytolytic T lymphocytes .
11564161	0	CD103	24,29	CD8	82,85	CD103	CD8	3682	925	Gene	Gene	beta7|appos|START_ENTITY Role|nmod|beta7 Role|nmod|localization localization|nmod|T T|compound|END_ENTITY	Role of integrin alphaE -LRB- CD103 -RRB- beta7 for tissue-specific epidermal localization of CD8 + T lymphocytes .
15196058	0	CD103	17,22	CD8	71,74	CD103	CD8	3682	925	Gene	Gene	START_ENTITY|advcl|promoting promoting|nmod|cells cells|compound|END_ENTITY	Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells .
15897278	0	CD103	21,26	CD8	41,44	CD103	CD8	3682	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	TGF - -LCB- beta -RCB- - dependent CD103 expression by CD8 -LRB- + -RRB- T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host_disease .
16920912	0	CD103	0,5	CD8	53,56	CD103	CD8	3682	925	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|cells cells|compound|END_ENTITY	CD103 is a marker for alloantigen-induced regulatory CD8 + T cells .
17452901	0	CD103	59,64	CD8	65,68	CD103	CD8	3682	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin enhances the number of alloantigen-induced human CD103 + CD8 + regulatory T cells in vitro .
18822329	0	CD103	35,40	CD8	31,34	CD103	CD8	3682	925	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|END_ENTITY	Alloantigen-induced regulatory CD8 + CD103 + T cells .
19150377	0	CD103	35,40	CD8	9,12	CD103	CD8	3682	925	Gene	Gene	express|dobj|START_ENTITY CD28|parataxis|express CD28|compound|END_ENTITY	Decidual CD8 + CD28 - T cells express CD103 but not perforin .
20541243	0	CD103	84,89	CD8	22,25	CD103	CD8	3682	925	Gene	Gene	expressing|dobj|START_ENTITY cells|dep|expressing cells|compound|END_ENTITY	Profound elevation of CD8 + T cells expressing the intraepithelial lymphocyte marker CD103 -LRB- alphaE/beta7 Integrin -RRB- in high-grade serous ovarian_cancer .
21778119	0	CD103	14,19	CD8	50,53	CD103	CD8	3682	925	Gene	Gene	Evaluation|nmod|START_ENTITY integrin|nsubj|Evaluation integrin|nmod|cells cells|compound|END_ENTITY	Evaluation of CD103 -LRB- aEb7 -RRB- integrin expression by CD8 T cells in blood as a surrogate marker to predict cervical T cell responses in the female genital tract during HIV_infection .
22043017	0	CD103	5,10	CD8	144,147	CD103	CD8	3682	925	Gene	Gene	transport|nsubj|START_ENTITY transport|nmod|presentation presentation|nmod|cells cells|compound|END_ENTITY	Lung CD103 + dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells .
22652413	0	CD103	27,32	CD8	35,38	CD103	CD8	3682	925	Gene	Gene	+|compound|START_ENTITY intraepithelial|appos|+ END_ENTITY|nsubj|intraepithelial	Increased intraepithelial -LRB- CD103 + -RRB- CD8 + T cells in the airways of smokers with and without chronic_obstructive_pulmonary_disease .
22802630	0	CD103	20,25	CD8	49,52	CD103	CD8	3682	925	Gene	Gene	+|nsubj|START_ENTITY +|xcomp|cells cells|compound|END_ENTITY	Cross-dressed CD8a + / CD103 + dendritic cells prime CD8 + T cells following vaccination .
23562160	0	CD103	57,62	CD8	64,67	CD103	CD8	3682	925	Gene	Gene	effector|compound|START_ENTITY effector|compound|END_ENTITY	Human CD1c + dendritic cells drive the differentiation of CD103 + CD8 + mucosal effector T cells via the cytokine TGF-b .
23861553	0	CD103	75,80	CD8	63,66	CD103	CD8	3682	925	Gene	Gene	+|compound|START_ENTITY characteristic|dep|+ characteristic|nmod|Foxp3 Foxp3|compound|END_ENTITY	Phenotypic and functional characteristic of a newly identified CD8 + Foxp3 - CD103 + regulatory T cells .
24477908	0	CD103	43,48	CD8	69,72	CD103	CD8	3682	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes .
25101220	0	CD103	30,35	CD8	89,92	CD103	CD8	3682	925	Gene	Gene	demarcates|nsubj|START_ENTITY demarcates|dobj|lymphocytes lymphocytes|amod|END_ENTITY	Location , location , location : CD103 demarcates intraepithelial , prognostically favorable CD8 -LRB- + -RRB- tumor-infiltrating lymphocytes in ovarian_cancer .
25308332	0	CD103	37,42	CD8	65,68	CD103	CD8	3682	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + T cell help guides formation of CD103 + lung-resident memory CD8 + T cells during influenza viral_infection .
25725111	0	CD103	4,9	CD8	0,3	CD103	CD8	3682	925	Gene	Gene	Lymphocytes|compound|START_ENTITY Lymphocytes|compound|END_ENTITY	CD8 + CD103 + Tumor-Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients .
27038842	0	CD103	0,5	CD8	30,33	CD103	CD8	3682	925	Gene	Gene	defines|nsubj|START_ENTITY defines|xcomp|lymphocytes lymphocytes|nsubj|+ +|compound|END_ENTITY	CD103 defines intraepithelial CD8 + PD1 + tumour-infiltrating lymphocytes of prognostic significance in endometrial_adenocarcinoma .
9566785	0	CD103	95,100	CD8	91,94	CD103	CD8	3682	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effector T lymphocyte subsets in human pancreatic_cancer : detection of CD8 + CD18 + cells and CD8 + CD103 + cells by multi-epitope imaging .
17620361	0	CD103	49,54	Foxp3	68,73	CD103	Foxp3	3682	50943	Gene	Gene	DCs|compound|START_ENTITY population|nmod|DCs induces|nsubj|population induces|dobj|cells cells|amod|END_ENTITY	A functionally specialized population of mucosal CD103 + DCs induces Foxp3 + regulatory T cells via a TGF-beta and retinoic_acid-dependent mechanism .
19079226	0	CD103	0,5	Foxp3	24,29	CD103	Foxp3	3682	50943	Gene	Gene	DCs|compound|START_ENTITY promote|nsubj|DCs promote|dobj|cells cells|amod|END_ENTITY	CD103 + GALT DCs promote Foxp3 + regulatory T cells .
23126599	0	CD103	31,36	Foxp3	47,52	CD103	Foxp3	3682	50943	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
23733880	0	CD103	78,83	Foxp3	132,137	CD103	Foxp3	16407(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY dehydrogenase|nmod|+ cells|amod|dehydrogenase retinaldehyde|dobj|cells retinaldehyde|advcl|induce induce|dobj|novo novo|compound|END_ENTITY	Cutting edge : inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103 + but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4 + T cells and promote airway tolerance .
23861553	0	CD103	75,80	Foxp3	68,73	CD103	Foxp3	3682	50943	Gene	Gene	+|compound|START_ENTITY characteristic|dep|+ characteristic|nmod|END_ENTITY	Phenotypic and functional characteristic of a newly identified CD8 + Foxp3 - CD103 + regulatory T cells .
19553521	0	CD103	15,20	IL-2	0,4	CD103	IL-2	16407(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates CD103 expression on CD4 + T cells in Scurfy mice that display both CD103-dependent and independent inflammation .
23126599	0	CD103	31,36	IL-2	83,87	CD103	IL-2	3682	3558	Gene	Gene	CD4|compound|START_ENTITY induction|nmod|CD4 END_ENTITY|nsubj|induction	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
24550510	0	CD103	26,31	Osteopontin	0,11	CD103	Osteopontin	3682	6696	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Osteopontin expression by CD103 - dendritic cells drives intestinal inflammation .
27038842	0	CD103	0,5	PD1	35,38	CD103	PD1	3682	5133	Gene	Gene	defines|nsubj|START_ENTITY defines|xcomp|lymphocytes lymphocytes|nsubj|+ +|compound|END_ENTITY	CD103 defines intraepithelial CD8 + PD1 + tumour-infiltrating lymphocytes of prognostic significance in endometrial_adenocarcinoma .
26770182	0	CD103	72,77	STAT3	142,147	CD103	STAT3	16407(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|dep|Phosphorylation Phosphorylation|nmod|END_ENTITY	3,3 ' - Diindolylmethane Inhibits Flt3L/GM-CSF-induced - bone Marrow-derived CD103 -LRB- + -RRB- Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5 .
12605119	0	CD103	133,138	interleukin-15	84,98	CD103	interleukin-15	3682	3600	Gene	Gene	T|compound|START_ENTITY development|nmod|T END_ENTITY|nmod|development	Tubulitis in renal allograft rejection : role of transforming_growth_factor-beta and interleukin-15 in development and maintenance of CD103 + intraepithelial T cells .
7529789	0	CD106	22,27	VCAM-1	14,20	CD106	VCAM-1	7412	7412	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of VCAM-1 -LRB- CD106 -RRB- by a subset of TCR gamma delta-bearing lymphocyte clones .
26621871	0	CD109	8,13	TGF-b	20,25	CD109	TGF-b	135228	7040	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	Soluble CD109 binds TGF-b and antagonizes TGF-b signaling and responses .
17704793	0	CD110	45,50	CD34	39,43	CD110	CD34	4352	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Failure to achieve a threshold dose of CD34 + CD110 + progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation .
19822297	0	CD110	44,49	CD34	39,43	CD110	CD34	4352	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Failure to achieve a threshold dose of CD34 + CD110 + progenitor cells in the graft predicts delayed platelet engraftment after autologous stem_cell_transplantation for multiple_myeloma .
19521665	0	CD111	111,116	CD133	62,67	CD111	CD133	5818	8842	Gene	Gene	express|dobj|START_ENTITY cells|acl:relcl|express cells|nummod|END_ENTITY	Engineered_herpes_simplex_viruses_efficiently_infect and kill CD133 + human glioma xenograft cells that express CD111 .
11091218	0	CD114	74,79	Granulocyte_colony-stimulating_factor	0,37	CD114	Granulocyte colony-stimulating factor	1441	1440	Gene	Gene	receptor|appos|START_ENTITY downregulates|dobj|receptor downregulates|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- downregulates its receptor -LRB- CD114 -RRB- on neutrophils and induces gelatinase B release in humans .
10882621	0	CD114	73,78	granulocyte_colony-stimulating_factor	25,62	CD114	granulocyte colony-stimulating factor	1441	1440	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Endotoxin down-modulates granulocyte_colony-stimulating_factor receptor -LRB- CD114 -RRB- on human neutrophils .
23742652	0	CD117	20,25	C-Kit	0,5	CD117	C-Kit	3815	3815	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	C-Kit SCF receptor -LRB- CD117 -RRB- expression and KIT gene mutation in conjunctival pigmented lesions .
15512818	0	CD117	16,21	C-kit	0,5	CD117	C-kit	3815	3815	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	C-kit receptor -LRB- CD117 -RRB- expression on plasma cells in monoclonal_gammopathies .
22846208	0	CD117	39,44	C-kit	32,37	CD117	C-kit	3815	3815	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|expression expression|nmod|END_ENTITY	Evaluation of the expression of C-kit -LRB- CD117 -RRB- in ependymomas and oligodendrogliomas .
8605274	0	CD117	16,21	C-kit	0,5	CD117	C-kit	3815	3815	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	C-kit receptor -LRB- CD117 -RRB- expression in acute_leukemia .
10350335	0	CD117	34,39	C-kit_receptor	18,32	CD117	C-kit receptor	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the C-kit_receptor -LRB- CD117 -RRB- is a feature of almost all subtypes of de novo acute_myeloblastic_leukemia -LRB- AML -RRB- , including cytogenetically good-risk AML , and lacks prognostic significance .
8759762	0	CD117	52,57	C5aR	37,41	CD117	C5aR	3815	728	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	CD88 antibodies specifically bind to C5aR on dermal CD117 + and CD14 + cells and react with a desmosomal antigen in human skin .
25045527	0	CD117	52,57	CD133	59,64	CD117	CD133	3815	8842	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	Recruitment and retention of human autologous CD34 + CD117 + CD133 + bone marrow stem cells to infarcted_myocardium followed by directed vasculogenesis : Novel strategy for cardiac regeneration .
16267071	0	CD117	25,30	CD34	16,20	CD117	CD34	3815	947	Gene	Gene	Mobilization|appos|START_ENTITY Mobilization|nmod|END_ENTITY	Mobilization of CD34 -LRB- + -RRB- , CD117 -LRB- + -RRB- , CXCR4 -LRB- + -RRB- , c-met -LRB- + -RRB- stem cells is correlated with left_ventricular_ejection_fraction and plasma NT-proBNP levels in patients with acute_myocardial_infarction .
24577437	0	CD117	0,5	CD34	28,32	CD117	CD34	3815	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|+ +|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
25045527	0	CD117	52,57	CD34	46,50	CD117	CD34	3815	947	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	Recruitment and retention of human autologous CD34 + CD117 + CD133 + bone marrow stem cells to infarcted_myocardium followed by directed vasculogenesis : Novel strategy for cardiac regeneration .
21469096	0	CD117	0,5	CD56	16,20	CD117	CD56	3815	4684	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD117 CD3 CD56 OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues .
25595995	0	CD117	20,25	CD56	28,32	CD117	CD56	3815	4684	Gene	Gene	-|dep|START_ENTITY -|compound|END_ENTITY	Intratumoral CD68 - , CD117 - , CD56 - , and CD1a-positive immune cells and the survival of Iranian patients with non-metastatic intestinal-type gastric_carcinoma .
11914628	0	CD117	19,24	KIT	14,17	CD117	KIT	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of KIT -LRB- CD117 -RRB- in angiomyolipoma .
14677065	0	CD117	10,15	KIT	5,8	CD117	KIT	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Rare KIT -LRB- CD117 -RRB- expression in multiple_myeloma abrogates the usefulness of imatinib mesylate treatment .
14692559	0	CD117	19,24	KIT	14,17	CD117	KIT	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of KIT -LRB- CD117 -RRB- in biphasic_pulmonary_blastoma .
15198361	0	CD117	23,28	KIT	18,21	CD117	KIT	3815	3815	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of KIT -LRB- CD117 -RRB- in chromophobe_renal_cell_carcinoma and renal_oncocytoma .
15336730	0	CD117	17,22	KIT	12,15	CD117	KIT	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Analysis of KIT -LRB- CD117 -RRB- expression in gallbladder_carcinomas by tissue microarray .
16015044	0	CD117	19,24	KIT	14,17	CD117	KIT	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of KIT -LRB- CD117 -RRB- in renal_cell_carcinoma and renal_oncocytoma .
17381803	0	CD117	42,47	KIT	37,40	CD117	KIT	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Merkel_cell_carcinoma : evaluation of KIT -LRB- CD117 -RRB- expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene - implications for treatment with imatinib_mesylate .
19683721	0	CD117	51,56	KIT	38,41	CD117	KIT	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|nmod|protein protein|compound|END_ENTITY	Immunohistochemical expression of the KIT protein -LRB- CD117 -RRB- in normal and neoplastic canine testes .
25634571	0	CD117	5,10	KIT	0,3	CD117	KIT	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	KIT -LRB- CD117 -RRB- Expression in Benign and Malignant Sweat Gland Tumors .
12591275	0	CD117	118,123	c-KIT	102,107	CD117	c-KIT	16590(Tax:10090)	16590(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Granulocyte_colony-stimulating_factor induces the release in the bone marrow of proteases that cleave c-KIT receptor -LRB- CD117 -RRB- from the surface of hematopoietic progenitor cells .
21057563	0	CD117	36,41	c-KIT	29,34	CD117	c-KIT	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Immunohistochemical study of c-KIT -LRB- CD117 -RRB- expression in renal_cell_carcinoma .
12683902	0	CD117	80,85	c-Kit	87,92	CD117	c-Kit	3815	3815	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	SYT-SSX2 variant of primary pulmonary synovial_sarcoma with focal expression of CD117 -LRB- c-Kit -RRB- protein and a poor clinical outcome .
14994370	0	CD117	16,21	c-Kit	0,5	CD117	c-Kit	3815	3815	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	c-Kit receptor -LRB- CD117 -RRB- expression on myeloblasts and white blood cell counts in acute_myeloid_leukemia .
19874361	0	CD117	7,12	c-Kit	0,5	CD117	c-Kit	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	c-Kit -LRB- CD117 -RRB- expression in classic Kaposi 's _ sarcoma .
11151069	0	CD117	21,26	c-kit	14,19	CD117	c-kit	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of c-kit -LRB- CD117 -RRB- in benign and malignant human endometrial epithelium .
12613538	0	CD117	67,72	c-kit	74,79	CD117	c-kit	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical identification of HER-2 / neu overexpression and CD117 -LRB- c-kit -RRB- expression in multiple myeloma .
15105813	0	CD117	15,20	c-kit	8,13	CD117	c-kit	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lack of c-kit -LRB- CD117 -RRB- expression in CD30 + lymphomas and lymphomatoid_papulosis .
16056250	0	CD117	14,19	c-kit	21,26	CD117	c-kit	3815	3815	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Expression of CD117 -LRB- c-kit -RRB- receptor in dysgerminoma_of_the_ovary : diagnostic and therapeutic implications .
16441409	0	CD117	21,26	c-kit	14,19	CD117	c-kit	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of c-kit -LRB- CD117 -RRB- in Spitz_nevus and malignant_melanoma .
18568298	0	CD117	27,32	c-kit	20,25	CD117	c-kit	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Characterization of c-kit -LRB- CD117 -RRB- expression in human normal pituitary cells and pituitary_adenomas .
20177846	0	CD117	7,12	c-kit	0,5	CD117	c-kit	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	c-kit -LRB- CD117 -RRB- expression in human tumors and its prognostic value : an immunohistochemical analysis .
24577437	0	CD117	0,5	c-kit	7,12	CD117	c-kit	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
25643775	0	CD117	35,40	c-kit	42,47	CD117	c-kit	3815	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Immunohistochemical Expression of CD117 -LRB- c-kit -RRB- in 75 Renal Cell Tumors -RSB- .
9718862	0	CD117	34,39	c-kit_receptor	18,32	CD117	c-kit receptor	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Thy-1 -LRB- CDw90 -RRB- and c-kit_receptor -LRB- CD117 -RRB- expression on CD34 + hematopoietic_progenitor_cells : a five dimensional flow cytometric study .
10090940	6	CD11a	796,801	CD18	803,807	CD11c	CD33	3687	945	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	CBDC expressed CD4 , CD11a , CD18 , CD45RA , CD50 , CD54 , and CD123 , but showed no expression of CD1a , CD11c , CD33 , CD40 , CD45R0 , CD80 , CD83 , and CD86 and only limited expression of CD58 , CD102 , and CD116 .
12064793	0	CD11a	17,22	CD4	56,59	CD11a	CD4	3683	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Up-regulation of CD11a -LRB- LFA-1 -RRB- expression on peripheral CD4 + T cells in primary_biliary_cirrhosis .
25414732	0	CD11a	45,50	CD4	55,58	CD11a	CD4	3683	920	Gene	Gene	ITGAL|appos|START_ENTITY ITGAL|nmod|END_ENTITY	Hypomethylation and overexpression of ITGAL -LRB- CD11a -RRB- in CD4 -LRB- + -RRB- T cells in systemic_sclerosis .
8859180	0	CD11a	25,30	CD8	34,37	CD11a	CD8	3683	925	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Functional expression of CD11a on CD8 + cells is suppressed in regional lymph nodes with cancer involvement in patients with gastrointestinal_carcinoma .
9796409	0	CD11a	29,34	CD8	24,27	CD11a	CD8	3683	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Remarkable increase of CD8 + CD11a + and CD8 + CD57 - T cells in patients with post-transfusion_graft-versus-host_disease -RSB- .
12020947	0	CD11a	52,57	ITGAL	45,50	CD11a	ITGAL	3683	3683	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Age-dependent DNA methylation changes in the ITGAL -LRB- CD11a -RRB- promoter .
12064793	0	CD11a	17,22	LFA-1	24,29	CD11a	LFA-1	3683	3683	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Up-regulation of CD11a -LRB- LFA-1 -RRB- expression on peripheral CD4 + T cells in primary_biliary_cirrhosis .
16164020	0	CD11a	36,41	RUNX3	0,5	CD11a	RUNX3	3683	864	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters .
8103515	0	CD11a	24,29	integrin_gene_promoter	53,75	CD11a	integrin gene promoter	3683	3683	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization of the CD11a -LRB- alpha L , LFA-1_alpha -RRB- integrin_gene_promoter .
17692319	0	CD11b	48,53	Angiotensin_II	0,14	CD11b	Angiotensin II	3684	183	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Angiotensin_II AT1 receptor blockade normalizes CD11b + monocyte production in bone marrow of hypercholesterolemic monkeys .
16797412	0	CD11b	108,113	B220	102,106	CD11b	B220	16409(Tax:10090)	19264(Tax:10090)	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	Interleukin-7 partially rescues B-lymphopoiesis in osteopetrotic oc/oc mice through the engagement of B220 + CD11b + progenitors .
18581322	0	CD11b	35,40	CCL2	0,4	CD11b	CCL2	3684	6347	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	CCL2 recruitment of IL-6-producing CD11b + monocytes to the draining lymph nodes during the initiation of Th17-dependent B cell-mediated autoimmunity .
25257053	0	CD11b	21,26	CCR7	16,20	CD11b	CCR7	16409(Tax:10090)	12775(Tax:10090)	Gene	Gene	homing|compound|START_ENTITY homing|compound|END_ENTITY	Dry_eye-induced CCR7 + CD11b + cell lymph_node homing is induced by COX-2 activities .
22306017	0	CD11b	48,53	CD103	40,45	CD11b	CD103	16409(Tax:10090)	16407(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|production production|nmod|END_ENTITY	Interleukin 23 production by intestinal CD103 -LRB- + -RRB- CD11b -LRB- + -RRB- dendritic cells in response to bacterial_flagellin_enhances_mucosal_innate_immune_defense .
22474352	0	CD11b	68,73	CD103	61,66	CD11b	CD103	16409(Tax:10090)	16407(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY populations|compound|END_ENTITY	Viral-induced encephalitis initiates distinct and functional CD103 + CD11b + brain dendritic cell populations within the olfactory bulb .
22129786	0	CD11b	165,170	CD11b	175,180	CD11b	CD11b	397459(Tax:9823)	397459(Tax:9823)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Molecular cloning , characterization and gene expression of the full length cDNA encoding the porcine CD11b -LRB- aM -RRB- and chromosomal localization of the porcine CD11a -LRB- aL -RRB- - CD11b -LRB- aM -RRB- - CD11b -LRB- aD -RRB- gene cluster .
22129786	0	CD11b	175,180	CD11b	165,170	CD11b	CD11b	397459(Tax:9823)	397459(Tax:9823)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Molecular cloning , characterization and gene expression of the full length cDNA encoding the porcine CD11b -LRB- aM -RRB- and chromosomal localization of the porcine CD11a -LRB- aL -RRB- - CD11b -LRB- aM -RRB- - CD11b -LRB- aD -RRB- gene cluster .
12874201	0	CD11b	130,135	CD11c	124,129	CD11b	CD11c	16409(Tax:10090)	16411(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	The immune response modifier and Toll-like_receptor_7 agonist S-27609 selectively induces IL-12 and TNF-alpha production in CD11c + CD11b + CD8 - dendritic cells .
15135320	0	CD11b	70,75	CD11c	76,81	CD11b	CD11c	16409(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Administration of macrophage_colony-stimulating_factor mobilized both CD11b + CD11c + cells and NK1 .1 + cells into peripheral blood .
15327893	0	CD11b	42,47	CD11c	36,41	CD11b	CD11c	16409(Tax:10090)	16411(Tax:10090)	Gene	Gene	CD8alpha|compound|START_ENTITY CD8alpha|compound|END_ENTITY	The CC_chemokine_ligand_3 regulates CD11c + CD11b + CD8alpha - dendritic cell maturation and activation following viral_infection_of_the_central_nervous_system : implications for a role in T cell activation .
16116221	0	CD11b	91,96	CD11c	81,86	CD11b	CD11c	3684	3687	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	TNF-alpha-dependent and - independent maturation of dendritic cells and recruited CD11c -LRB- int -RRB- CD11b + Cells during oral Salmonella_infection .
16508971	0	CD11b	36,41	CD11c	29,34	CD11b	CD11c	16409(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY abundant|nsubj|cells abundant|ccomp|+ +|nsubj|END_ENTITY	Antigen-induced , tolerogenic CD11c + , CD11b + dendritic cells are abundant in Peyer 's patches during the induction of oral tolerance to type II collagen and suppress experimental collagen-induced_arthritis .
18541300	0	CD11b	53,58	CD11c	9,14	CD11b	CD11c	3684	3687	Gene	Gene	monocyte|nmod|START_ENTITY contributes|xcomp|monocyte contributes|nsubj|END_ENTITY	Integrin CD11c contributes to monocyte adhesion with CD11b in a differential manner and requires Src family kinase activity .
22504639	0	CD11b	42,47	CD11c	35,40	CD11b	CD11c	16409(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY regulates|nsubj|cells +|ccomp|regulates +|nsubj|mTORC1 mTORC1|nmod|END_ENTITY	Cutting edge : mTORC1 in intestinal CD11c + CD11b + dendritic cells regulates intestinal homeostasis by promoting IL-10 production .
22822029	0	CD11b	9,14	CD11c	0,5	CD11b	CD11c	16409(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY critical|nsubj|cells /|ccomp|critical /|nsubj|END_ENTITY	CD11c -LRB- + -RRB- / CD11b -LRB- + -RRB- cells are critical for organic dust-elicited murine_lung_inflammation .
26913030	0	CD11b	55,60	CD11c	48,53	CD11b	CD11c	16409(Tax:10090)	16411(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|dep|Early Early|nmod|Numbers Numbers|nmod|END_ENTITY	Early Ovariectomy Results in Reduced Numbers of CD11c + / CD11b + Spleen Cells and Impacts Disease Expression in Murine Lupus .
19572148	0	CD11b	84,89	CD14	91,95	CD11b	CD14	3684	929	Gene	Gene	alterations|nmod|START_ENTITY +|nsubj|alterations +|dep|+ +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
19041316	0	CD11b	65,70	CD15	72,76	CD11b	CD15	3684	2526	Gene	Gene	granulocytes|compound|START_ENTITY granulocytes|compound|END_ENTITY	Delayed processing of blood increases the frequency of activated CD11b + CD15 + granulocytes which inhibit T cell function .
19369244	0	CD11b	10,15	CD15	17,21	CD11b	CD15	3684	2526	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activated CD11b + CD15 + granulocytes increase in the blood of patients with uveal_melanoma .
19572148	0	CD11b	84,89	CD15	99,103	CD11b	CD15	3684	2526	Gene	Gene	alterations|nmod|START_ENTITY +|nsubj|alterations +|dep|+ +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
9335318	0	CD11b	43,48	CD15	38,42	CD11b	CD15	3684	2526	Gene	Gene	START_ENTITY|nummod|+ +|compound|END_ENTITY	Characterization of a culture-derived CD15 + CD11b - promyelocytic population from CD34 + peripheral blood cells .
1387727	0	CD11b	14,19	CD16	57,61	CD11b	CD16	3684	2214	Gene	Gene	antigen|amod|START_ENTITY Expression|nmod|antigen Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
11035618	0	CD11b	29,34	CD28	23,27	CD11b	CD28	3684	940	Gene	Gene	Expansion|dep|START_ENTITY Expansion|nmod|END_ENTITY	Expansion of rare CD8 + CD28 - CD11b - T cells with impaired effector functions in HIV-1-infected patients .
11145666	0	CD11b	0,5	CD28	32,36	CD11b	CD28	3684	940	Gene	Gene	expression|amod|START_ENTITY identifies|nsubj|expression identifies|ccomp|lymphocytes lymphocytes|nsubj|T T|compound|END_ENTITY	CD11b expression identifies CD8 + CD28 + T lymphocytes with phenotype and function of both naive/memory and effector cells .
1387727	0	CD11b	14,19	CD4	45,48	CD11b	CD4	3684	920	Gene	Gene	antigen|amod|START_ENTITY Expression|nmod|antigen Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
14602575	0	CD11b	98,103	CD45	88,92	CD11b	CD45	16409(Tax:10090)	19264(Tax:10090)	Gene	Gene	monocytes|amod|START_ENTITY monocytes|amod|END_ENTITY	CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45 -LRB- high -RRB- CD11b -LRB- + -RRB- monocytes and enhanced Theiler 's murine encephalomyelitis virus-induced demyelinating_disease .
11035618	0	CD11b	29,34	CD8	18,21	CD11b	CD8	3684	925	Gene	Gene	Expansion|dep|START_ENTITY Expansion|nmod|CD28 CD28|compound|END_ENTITY	Expansion of rare CD8 + CD28 - CD11b - T cells with impaired effector functions in HIV-1-infected patients .
11145666	0	CD11b	0,5	CD8	28,31	CD11b	CD8	3684	925	Gene	Gene	expression|amod|START_ENTITY identifies|nsubj|expression identifies|ccomp|lymphocytes lymphocytes|nsubj|T T|compound|END_ENTITY	CD11b expression identifies CD8 + CD28 + T lymphocytes with phenotype and function of both naive/memory and effector cells .
12021304	0	CD11b	10,15	CD8	75,78	CD11b	CD8	3684	925	Gene	Gene	cells|amod|START_ENTITY exogenous|nsubj|cells exogenous|nmod|cells cells|compound|END_ENTITY	CD8alpha - CD11b + dendritic cells present exogenous virus-like particles to CD8 + T cells and subsequently express CD8alpha and CD205 molecules .
1387727	0	CD11b	14,19	CD8	51,54	CD11b	CD8	3684	925	Gene	Gene	antigen|amod|START_ENTITY Expression|nmod|antigen Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
1500720	0	CD11b	0,5	CD8	28,31	CD11b	CD8	3684	925	Gene	Gene	START_ENTITY|dep|marker marker|nmod|activation activation|compound|END_ENTITY	CD11b -LRB- Mac-1 -RRB- : a marker for CD8 + cytotoxic T cell activation and memory in virus_infection .
15067204	0	CD11b	83,88	CD8	98,101	CD11b	CD8	3684	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8 + cells in vivo .
15208607	0	CD11b	89,94	CD8	62,65	CD11b	CD8	3684	925	Gene	Gene	binding|nmod|START_ENTITY attenuates|nmod|binding attenuates|dobj|adhesion adhesion|nmod|cells cells|compound|END_ENTITY	Epigallocatechin_gallate attenuates adhesion and migration of CD8 + T cells by binding to CD11b .
1828937	0	CD11b	90,95	CD8	5,8	CD11b	CD8	3684	925	Gene	Gene	CD57|compound|START_ENTITY lack|dobj|CD57 cells|acl:relcl|lack cells|nsubj|cells cells|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
1899870	0	CD11b	10,15	CD8	0,3	CD11b	CD8	3684	925	Gene	Gene	START_ENTITY|nummod|+ +|compound|END_ENTITY	CD8 + high CD11b + low T cells -LRB- T suppressor-effectors -RRB- in multiple_sclerosis cerebrospinal fluid are increased during high dose corticosteroid treatment .
2023064	0	CD11b	113,118	CD8	108,111	CD11b	CD8	3684	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Quantitative changes in T helper inducer -LRB- CD4 + CD45RA - -RRB- , T suppressor inducer -LRB- CD4 + CD45RA + -RRB- , T suppressor -LRB- CD8 + CD11b + -RRB- , and T cytotoxic -LRB- CD8 + CD11b - -RRB- subsets in human_immunodeficiency_virus_infection .
2023064	0	CD11b	144,149	CD8	139,142	CD11b	CD8	3684	925	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Quantitative changes in T helper inducer -LRB- CD4 + CD45RA - -RRB- , T suppressor inducer -LRB- CD4 + CD45RA + -RRB- , T suppressor -LRB- CD8 + CD11b + -RRB- , and T cytotoxic -LRB- CD8 + CD11b - -RRB- subsets in human_immunodeficiency_virus_infection .
2502419	0	CD11b	4,9	CD8	0,3	CD11b	CD8	3684	925	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	CD8 + CD11b + peripheral blood T lymphocytes contain lymphokine-activated killer cell precursors .
25024388	0	CD11b	21,26	CD8	100,103	CD11b	CD8	3684	925	Gene	Gene	cells|amod|START_ENTITY targeting|nmod|cells Antigen|acl|targeting promotes|nsubj|Antigen promotes|dobj|responses responses|compound|END_ENTITY	Antigen targeting to CD11b + dendritic cells in association with TLR4/TRIF signaling promotes strong CD8 + T cell responses .
9276527	0	CD11b	18,23	CD8	13,16	CD11b	CD8	3684	925	Gene	Gene	Leu-8|compound|START_ENTITY Leu-8|compound|END_ENTITY	Elevation of CD8 + CD11b + Leu-8 - T cells is associated with the humoral immunodeficiency in myeloma patients .
16818658	0	CD11b	70,75	CD80	0,4	CD11b	CD80	16409(Tax:10090)	12519(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	CD80 in immune suppression by mouse ovarian_carcinoma-associated Gr-1 + CD11b + myeloid cells .
22403256	0	CD11b	106,111	CX3CR1	99,105	CD11b	CX3CR1	16409(Tax:10090)	13051(Tax:10090)	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1 + CD11b + F4/80 + regulatory macrophages in mice .
22403256	0	CD11b	106,111	F4/80	112,117	CD11b	F4/80	16409(Tax:10090)	13733(Tax:10090)	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1 + CD11b + F4/80 + regulatory macrophages in mice .
9935015	0	CD11b	47,52	Fab	13,16	CD11b	Fab	3684	2187	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Chimeric 7E3 Fab -LRB- ReoPro -RRB- decreases detectable CD11b on neutrophils from patients undergoing coronary angioplasty .
15728461	0	CD11b	74,79	Flt3	69,73	CD11b	Flt3	16409(Tax:10090)	14255(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Progressive and controlled development of mouse dendritic cells from Flt3 + CD11b + progenitors in vitro .
16339559	0	CD11b	0,5	Gr-1	7,11	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|parataxis|immature immature|nsubj|+ +|compound|END_ENTITY	CD11b + / Gr-1 + immature myeloid cells mediate suppression of T cells in mice bearing_tumors of IL-1beta-secreting cells .
19265258	0	CD11b	49,54	Gr-1	55,59	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Potential differentiation of tumor bearing mouse CD11b + Gr-1 + immature myeloid cells into both suppressor macrophages and immunostimulatory dendritic cells .
19789345	0	CD11b	84,89	Gr-1	79,83	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|+ +|amod|END_ENTITY	Vascular_adhesion protein-1 enhances tumor growth by supporting recruitment of Gr-1 + CD11b + myeloid cells into tumors .
20631080	0	CD11b	5,10	Gr-1	0,4	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Gr-1 + CD11b + myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung .
21949025	0	CD11b	26,31	Gr-1	33,37	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	expands|dobj|START_ENTITY expands|nsubj|END_ENTITY	IL-33 expands suppressive CD11b + Gr-1 -LRB- int -RRB- and regulatory T cells , including ST2L + Foxp3 + cells , and mediates regulatory T cell-dependent promotion of cardiac allograft survival .
22030957	0	CD11b	72,77	Gr-1	66,70	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	UV light B-mediated inhibition of skin catalase activity promotes Gr-1 + CD11b + myeloid cell expansion .
22962327	0	CD11b	114,119	Gr-1	123,127	CD11b	Gr-1	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY Acceleration|nmod|expression Acceleration|dep|cells cells|amod|END_ENTITY	Acceleration of collateral development by carcinoembryonic_antigen-related_cell_adhesion_molecule_1 expression on CD11b / Gr-1 myeloid cells -- brief report .
24645717	0	CD11b	5,10	Gr-1	0,4	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Gr-1 + CD11b + myeloid cells efficiently home to site of injury after intravenous administration and enhance diabetic wound healing by neoangiogenesis .
24758901	0	CD11b	47,52	Gr-1	55,59	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Hydrogen_sulfide attenuates the recruitment of CD11b Gr-1 myeloid cells and regulates Bax/Bcl -2 signaling in myocardial_ischemia injury .
24776637	0	CD11b	5,10	Gr-1	0,4	CD11b	Gr-1	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Gr-1 + CD11b + cells facilitate Lewis lung_cancer recurrence by enhancing neovasculature after local_irradiation .
25085111	0	CD11b	79,84	Gr-1	74,78	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|+ +|amod|END_ENTITY	Liver metastases induce reversible hepatic B cell dysfunction mediated by Gr-1 + CD11b + myeloid cells .
25108427	0	CD11b	25,30	Gr-1	17,21	CD11b	Gr-1	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	-LSB- Myeloid-derived Gr-1 CD11b suppressor cells are involved in immunoregulation of experimental_autoimmune_encephalomyelitis -RSB- .
25269085	0	CD11b	5,10	Gr-1	0,4	CD11b	Gr-1	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Gr-1 + CD11b + Immature Myeloid Cells -LRB- IMC -RRB- Promote Resistance of Pro-Inflammatory T Cells to Suppression by Regulatory T Cells in Atherosclerotic Apo_E - Deficient Mice .
26582821	0	CD11b	23,28	Gr-1	17,21	CD11b	Gr-1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY acquire|nsubj|cells +|ccomp|acquire +|nsubj|END_ENTITY	Immature myeloid Gr-1 + CD11b + cells from lipopolysaccharide-immunosuppressed mice acquire inhibitory activity in the bone marrow and migrate to lymph nodes to exert their suppressive function .
16352631	0	CD11b	130,135	Gr1	126,129	CD11b	Gr1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Granulocyte_colony-stimulating_factor promotes tumor angiogenesis via increasing circulating endothelial progenitor cells and Gr1 + CD11b + cells in cancer animal models .
17664940	0	CD11b	59,64	Gr1	65,68	CD11b	Gr1	3684	14782(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Tumor refractoriness to anti-VEGF treatment is mediated by CD11b + Gr1 + myeloid cells .
21184649	0	CD11b	21,26	Gr1	17,20	CD11b	Gr1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Up-regulation of Gr1 + CD11b + population in spleen of dextran sulfate_sodium administered mice works to repair colitis .
21413942	0	CD11b	48,53	Gr1	42,45	CD11b	Gr1	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Dextran sulphate_sodium increases splenic Gr1 -LRB- + -RRB- CD11b -LRB- + -RRB- cells which accelerate recovery from colitis following intravenous transplantation .
24072746	0	CD11b	45,50	Gr1	51,54	CD11b	Gr1	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	growth|amod|START_ENTITY growth|compound|END_ENTITY	Parathyroid_hormone-related_protein drives a CD11b + Gr1 + cell-mediated positive feedback loop_to_support_prostate_cancer growth .
24343652	0	CD11b	58,63	Gr1	65,68	CD11b	Gr1	16409(Tax:10090)	14782(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|allergic_airway_inflammation allergic_airway_inflammation|amod|END_ENTITY	Salmonella_enterica_serovar_Typhimurium infection-induced CD11b + Gr1 + cells ameliorate allergic_airway_inflammation .
25008148	0	CD11b	21,26	Gr1	15,18	CD11b	Gr1	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	F4/80|amod|START_ENTITY F4/80|amod|END_ENTITY	Recruitment of Gr1 -LRB- + -RRB- CD11b -LRB- + -RRB- F4/80 -LRB- + -RRB- Population in the Bone Marrow and Spleen by Irradiation-Induced Pulmonary Damage .
16772369	0	CD11b	86,91	IL-18	0,5	CD11b	IL-18	16409(Tax:10090)	16173(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymus .
17675559	0	CD11b	29,34	L-selectin	55,65	CD11b	L-selectin	3684	6402	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils .
20144655	3	CD11b	510,515	Ly-6G	519,524	CD11b	Ly-6G	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	population|amod|START_ENTITY population|amod|END_ENTITY	Our data demonstrated that CTX actually did mobilize an immunosuppressive myeloid CD11b -LRB- + -RRB- Ly-6G -LRB- - -RRB- population in the NOD mouse spleen in addition to a well-identified neutrophil CD11b -LRB- + -RRB- Ly-6G -LRB- + -RRB- population .
20574007	0	CD11b	74,79	Ly-6G	80,85	CD11b	Ly-6G	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Tim-3 / galectin-9 pathway : regulation of Th1 immunity through promotion of CD11b + Ly-6G + myeloid cells .
21170045	0	CD11b	124,129	Ly6G	130,134	CD11b	Ly6G	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Histamine_deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b + Ly6G + immature myeloid cells .
23374140	0	CD11b	38,43	Ly6G	32,36	CD11b	Ly6G	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	blood|amod|START_ENTITY monocyte|nsubj|blood rescues|parataxis|monocyte rescues|dobj|END_ENTITY	A modified superantigen rescues Ly6G - CD11b + blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE .
24114144	0	CD11b	13,18	Ly6G	21,25	CD11b	Ly6G	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	Ly6C|amod|START_ENTITY Ly6C|amod|END_ENTITY	Expansion of CD11b -LRB- + -RRB- Ly6G -LRB- + -RRB- Ly6C -LRB- int -RRB- cells driven by medroxyprogesterone_acetate in mice bearing breast_tumors restrains NK cell effector functions .
24711563	0	CD11b	0,5	Ly6G	14,18	CD11b	Ly6G	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nummod|+	CD11b + Ly6Chi Ly6G - immature myeloid cells recruited in response to Salmonella_enterica_serovar_Typhimurium infection exhibit protective and immunosuppressive properties .
26942073	0	CD11b	0,5	Ly6G	6,10	CD11b	Ly6G	16409(Tax:10090)	546644(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	CD11b + Ly6G + cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis .
17823696	0	CD11b	33,38	Mac-1	40,45	CD11b	Mac-1	3684	3684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Increased Expression of Monocyte CD11b -LRB- Mac-1 -RRB- in Overweight Recent-Onset Type 1 Diabetic Children .
12383860	0	CD11b	33,38	PACAP	0,5	CD11b	PACAP	3684	116	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	PACAP enhances the expression of CD11b , CD66b and CD63 in human neutrophils .
26608915	0	CD11b	38,43	S100A8	0,6	CD11b	S100A8	16409(Tax:10090)	20201(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	S100A8 Production in CXCR2-Expressing CD11b + Gr-1high Cells Aggravates Hepatitis in Mice Fed a High-Fat and High-Cholesterol Diet .
15746186	0	CD11b	59,64	TGF-beta1	22,31	CD11b	TGF-beta1	3684	7040	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Inhibitory control of TGF-beta1 on the activation of Rap1 , CD11b , and transendothelial migration of leukocytes .
22962327	0	CD11b	114,119	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	42,99	CD11b	carcinoembryonic antigen-related cell adhesion molecule 1	16409(Tax:10090)	26365(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Acceleration of collateral development by carcinoembryonic_antigen-related_cell_adhesion_molecule_1 expression on CD11b / Gr-1 myeloid cells -- brief report .
10946285	0	CD11b	113,118	gp96	85,89	CD11b	gp96	3684	7184	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Saturation , competition , and specificity in interaction of heat_shock proteins -LRB- hsp -RRB- gp96 , hsp90 , and hsp70 with CD11b + cells .
22507226	0	CD11b	59,64	gr-1	66,70	CD11b	gr-1	3684	546644(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|splenocytes splenocytes|amod|END_ENTITY	Murine_gammaherpesvirus-68 expands , but does not activate , CD11b + gr-1 + splenocytes in vivo .
22475305	0	CD11b	104,109	granulocyte_colony-stimulating_factor	36,73	CD11b	granulocyte colony-stimulating factor	3684	1440	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	In vivo effect of recombinant human granulocyte_colony-stimulating_factor on neutrophilic expression of CD11b in septic neonates : a randomized controlled trial .
22528488	0	CD11b	72,77	granulocyte_colony-stimulating_factor	31,68	CD11b	granulocyte colony-stimulating factor	3684	1440	Gene	Gene	Gr1|amod|START_ENTITY END_ENTITY|nmod|Gr1	Induction of Bv8 expression by granulocyte_colony-stimulating_factor in CD11b + Gr1 + cells : key role of Stat3 signaling .
26155126	0	CD11b	14,19	interleukin-2	78,91	CD11b	interleukin-2	3684	3558	Gene	Gene	Expression|nmod|START_ENTITY stimulated|nsubj|Expression stimulated|nmod|END_ENTITY	Expression of CD11b and CD18 on polymorphonuclear neutrophils stimulated with interleukin-2 .
8101106	0	CD11b	66,71	p65_subunit_of_NF-kappa_B	34,59	CD11b	p65 subunit of NF-kappa B	3684	5970	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Antisense oligonucleotides to the p65_subunit_of_NF-kappa_B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes .
16698686	0	CD11c	14,19	BDCA-1	25,31	CD11c	BDCA-1	3687	911	Gene	Gene	DC|amod|START_ENTITY DC|compound|END_ENTITY	CD34 + - derived CD11c + _ + + BDCA-1 + + CD123 + + DC : expansion of a phenotypically undescribed myeloid DC1 population for use in adoptive immunotherapy .
17786242	0	CD11c	53,58	BDCA-1	59,65	CD11c	BDCA-1	3687	911	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Normal human dermis contains distinct populations of CD11c + BDCA-1 + dendritic cells and CD163 + FXIIIA + macrophages .
12874201	0	CD11c	124,129	CD11b	130,135	CD11c	CD11b	16411(Tax:10090)	16409(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	The immune response modifier and Toll-like_receptor_7 agonist S-27609 selectively induces IL-12 and TNF-alpha production in CD11c + CD11b + CD8 - dendritic cells .
15135320	0	CD11c	76,81	CD11b	70,75	CD11c	CD11b	16411(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Administration of macrophage_colony-stimulating_factor mobilized both CD11b + CD11c + cells and NK1 .1 + cells into peripheral blood .
15327893	0	CD11c	36,41	CD11b	42,47	CD11c	CD11b	16411(Tax:10090)	16409(Tax:10090)	Gene	Gene	CD8alpha|compound|START_ENTITY CD8alpha|compound|END_ENTITY	The CC_chemokine_ligand_3 regulates CD11c + CD11b + CD8alpha - dendritic cell maturation and activation following viral_infection_of_the_central_nervous_system : implications for a role in T cell activation .
16116221	0	CD11c	81,86	CD11b	91,96	CD11c	CD11b	3687	3684	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	TNF-alpha-dependent and - independent maturation of dendritic cells and recruited CD11c -LRB- int -RRB- CD11b + Cells during oral Salmonella_infection .
16508971	0	CD11c	29,34	CD11b	36,41	CD11c	CD11b	16411(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY abundant|ccomp|+ abundant|nsubj|cells cells|amod|END_ENTITY	Antigen-induced , tolerogenic CD11c + , CD11b + dendritic cells are abundant in Peyer 's patches during the induction of oral tolerance to type II collagen and suppress experimental collagen-induced_arthritis .
18541300	0	CD11c	9,14	CD11b	53,58	CD11c	CD11b	3687	3684	Gene	Gene	contributes|nsubj|START_ENTITY contributes|xcomp|monocyte monocyte|nmod|END_ENTITY	Integrin CD11c contributes to monocyte adhesion with CD11b in a differential manner and requires Src family kinase activity .
22504639	0	CD11c	35,40	CD11b	42,47	CD11c	CD11b	16411(Tax:10090)	16409(Tax:10090)	Gene	Gene	mTORC1|nmod|START_ENTITY +|nsubj|mTORC1 +|ccomp|regulates regulates|nsubj|cells cells|amod|END_ENTITY	Cutting edge : mTORC1 in intestinal CD11c + CD11b + dendritic cells regulates intestinal homeostasis by promoting IL-10 production .
22822029	0	CD11c	0,5	CD11b	9,14	CD11c	CD11b	16411(Tax:10090)	16409(Tax:10090)	Gene	Gene	/|nsubj|START_ENTITY /|ccomp|critical critical|nsubj|cells cells|amod|END_ENTITY	CD11c -LRB- + -RRB- / CD11b -LRB- + -RRB- cells are critical for organic dust-elicited murine_lung_inflammation .
26913030	0	CD11c	48,53	CD11b	55,60	CD11c	CD11b	16411(Tax:10090)	16409(Tax:10090)	Gene	Gene	Numbers|nmod|START_ENTITY Early|nmod|Numbers Cells|dep|Early Cells|compound|END_ENTITY	Early Ovariectomy Results in Reduced Numbers of CD11c + / CD11b + Spleen Cells and Impacts Disease Expression in Murine Lupus .
23018460	0	CD11c	107,112	CD122	118,123	CD11c	CD122	16411(Tax:10090)	16185(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Efficient xenoengraftment in severe immunodeficient_NOD / Shi-scid IL2rynull mice is attributed to a lack of CD11c + B220 + CD122 + cells .
15699162	0	CD11c	80,85	CD14	75,79	CD11c	CD14	3687	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CpG RNA : identification of novel single-stranded RNA that stimulates human CD14 + CD11c + monocytes .
20479115	0	CD11c	69,74	CD141	75,80	CD11c	CD141	3687	7056	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Superior antigen cross-presentation and XCR1 expression define human CD11c + CD141 + cells as homologues of mouse CD8 + dendritic cells .
21392045	0	CD11c	18,23	CD163	11,16	CD11c	CD163	16411(Tax:10090)	93671(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Density of CD163 + CD11c + dendritic cells increases and CD103 + dendritic cells decreases in the coeliac_lesion .
8652389	0	CD11c	86,91	CD44	58,62	CD11c	CD44	3687	960	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	An aggressive subtype of B-CLL is characterized by strong CD44 expression and lack of CD11c .
15294984	0	CD11c	31,36	CD8	82,85	CD11c	CD8	3687	925	Gene	Gene	activation|nmod|START_ENTITY +|nsubj|activation +|dobj|cells cells|nmod|responses responses|compound|END_ENTITY	Partial activation of neonatal CD11c + dendritic cells and induction of adult-like CD8 + cytotoxic T cell responses by synthetic microspheres .
16524567	0	CD11c	86,91	CD8	44,47	CD11c	CD8	3687	925	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells enhances|nmod|induction enhances|dobj|responses responses|compound|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
16524567	0	CD11c	86,91	CD8	92,95	CD11c	CD8	3687	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
20479115	0	CD11c	69,74	CD8	111,114	CD11c	CD8	3687	925	Gene	Gene	cells|amod|START_ENTITY define|dobj|cells define|nmod|homologues homologues|nmod|cells cells|compound|END_ENTITY	Superior antigen cross-presentation and XCR1 expression define human CD11c + CD141 + cells as homologues of mouse CD8 + dendritic cells .
20610651	0	CD11c	106,111	CD8	0,3	CD11c	CD8	16411(Tax:10090)	925	Gene	Gene	cells|amod|START_ENTITY dependent|nmod|cells serotype|ccomp|dependent serotype|nsubj|responses responses|compound|END_ENTITY	CD8 + T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c + dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling .
22934250	0	CD11c	104,109	CD8a	113,117	CD11c	CD8a	16411(Tax:10090)	12525(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|dep|END_ENTITY	Cross-priming for antitumor CTL induced by soluble Ag + polyI : C depends on the TICAM-1 pathway in mouse CD11c -LRB- + -RRB- / CD8a -LRB- + -RRB- dendritic cells .
12091350	0	CD11c	27,32	CD8alpha	107,115	CD11c	CD8alpha	16411(Tax:10090)	12525(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|cells cells|nmod|precursor precursor|nmod|cells cells|amod|END_ENTITY	Identification of CD8alpha + CD11c - lineage phenotype-negative cells in the spleen as committed precursor of CD8alpha + dendritic cells .
17760559	0	CD11c	121,126	CD8alpha	127,135	CD11c	CD8alpha	16411(Tax:10090)	12525(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Big tumor regression induced by GM-CSF gene-modified 3LL tumor cells via facilitating DC maturation and deviation toward CD11c + CD8alpha + subset .
24711412	0	CD11c	19,24	CX3CR1	26,32	CD11c	CX3CR1	3687	1524	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Differentiation of CD11c + CX3CR1 + cells in the small intestine requires Notch signaling .
15004163	0	CD11c	31,36	Flt3_ligand	6,17	CD11c	Flt3 ligand	16411(Tax:10090)	14256(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	Nasal Flt3_ligand cDNA elicits CD11c + CD8 + dendritic cells for enhanced mucosal immunity .
10861034	0	CD11c	55,60	GM-CSF	29,35	CD11c	GM-CSF	16411(Tax:10090)	12981(Tax:10090)	Gene	Gene	expands|dobj|START_ENTITY expands|nsubj|END_ENTITY	Polyethylene_glycol-modified GM-CSF expands CD11b -LRB- high -RRB- CD11c -LRB- high -RRB- but notCD11b -LRB- low -RRB- CD11c -LRB- high -RRB- murine dendritic cells in vivo : a comparative analysis with Flt3_ligand .
16645593	0	CD11c	39,44	IL-20	24,29	CD11c	IL-20	3687	50604	Gene	Gene	cells|amod|START_ENTITY production|dep|cells production|nmod|END_ENTITY	Prominent production of IL-20 by CD68 + / CD11c + myeloid-derived cells in psoriasis : Gene regulation and cellular effects .
22815909	0	CD11c	51,56	IRF7	0,4	CD11c	IRF7	16411(Tax:10090)	54123(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	IRF7 regulates TLR2-mediated activation of splenic CD11c -LRB- hi -RRB- dendritic cells .
22990073	0	CD11c	40,45	JunD	76,80	CD11c	JunD	16411(Tax:10090)	16478(Tax:10090)	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells .
25714599	0	CD11c	102,107	LDLR	149,153	CD11c	LDLR	16411(Tax:10090)	16835(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Probucol protects against atherosclerosis through lipid-lowering and suppressing immune maturation of CD11c + dendritic cells in STZ-induced diabetic LDLR - / - mice .
18166336	0	CD11c	178,183	MHC_II	185,191	CD11c	MHC II	16411(Tax:10090)	111364(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Stress-induced differences in primary and secondary resistance against bacterial_sepsis corresponds with diverse corticotropin releasing hormone receptor expression by pulmonary CD11c + MHC_II + and CD11c - MHC_II + APCs .
18166336	0	CD11c	197,202	MHC_II	204,210	CD11c	MHC II	16411(Tax:10090)	111364(Tax:10090)	Gene	Gene	START_ENTITY|dep|APCs APCs|compound|END_ENTITY	Stress-induced differences in primary and secondary resistance against bacterial_sepsis corresponds with diverse corticotropin releasing hormone receptor expression by pulmonary CD11c + MHC_II + and CD11c - MHC_II + APCs .
19255186	0	CD11c	38,43	SOCS3	15,20	CD11c	SOCS3	16411(Tax:10090)	12702(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Involvement of SOCS3 in regulation of CD11c + dendritic cell-derived osteoclastogenesis and severe alveolar_bone_loss .
22934250	0	CD11c	104,109	TICAM-1	79,86	CD11c	TICAM-1	16411(Tax:10090)	106759(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Cross-priming for antitumor CTL induced by soluble Ag + polyI : C depends on the TICAM-1 pathway in mouse CD11c -LRB- + -RRB- / CD8a -LRB- + -RRB- dendritic cells .
24519489	0	CD11c	79,84	aryl_hydrocarbon_receptor	34,59	CD11c	aryl hydrocarbon receptor	3687	196	Gene	Gene	cells|amod|START_ENTITY function|nmod|cells END_ENTITY|nmod|function	New insights into the role of the aryl_hydrocarbon_receptor in the function of CD11c cells during respiratory viral infection .
27068235	0	CD11c	48,53	aryl_hydrocarbon_receptor	13,38	CD11c	aryl hydrocarbon receptor	16411(Tax:10090)	11622(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Ablating the aryl_hydrocarbon_receptor -LRB- AhR -RRB- in CD11c + cells perturbs intestinal epithelium development and intestinal immunity .
10845922	0	CD11c	24,29	beta2	30,35	CD11c	beta2	3687	10242	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Engagement of CD11b and CD11c beta2 integrin by antibodies or soluble CD23 induces IL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways .
16716806	0	CD11c	46,51	phospholipase_D1	67,83	CD11c	phospholipase D1	3687	5337	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase_D1 activation in U937 cells .
11278725	0	CD120a	54,60	Bcl-2	76,81	CD120a	Bcl-2	7132	596	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Phosphorylation of the tumor necrosis factor receptor CD120a -LRB- p55 -RRB- recruits Bcl-2 and protects against apoptosis .
10708710	0	CD120a	40,46	p55	4,7	CD120a	p55	7132	7132	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The p55 tumor necrosis factor receptor -LRB- CD120a -RRB- induces endothelin-1 synthesis in endothelial and epithelial cells .
10433809	0	CD120a	48,54	tumour_necrosis_factor	14,36	CD120a	tumour necrosis factor	7132	7124	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|receptors receptors|compound|END_ENTITY	Expression of tumour_necrosis_factor receptors -LRB- CD120a and CD120b -RRB- on bronchoalveolar cells .
23018460	0	CD122	118,123	CD11c	107,112	CD122	CD11c	16185(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Efficient xenoengraftment in severe immunodeficient_NOD / Shi-scid IL2rynull mice is attributed to a lack of CD11c + B220 + CD122 + cells .
19609979	0	CD122	62,67	CD8	58,61	CD122	CD8	16185(Tax:10090)	925	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
19609979	0	CD122	62,67	CD8	6,9	CD122	CD8	16185(Tax:10090)	925	Gene	Gene	Treg|compound|START_ENTITY function|nmod|Treg have|dobj|function have|nsubj|cells cells|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
19609979	6	CD122	954,959	CD8	948,951	CXCR3	CD8	12766(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	While CD8 -LRB- + -RRB- CD122 -LRB- + -RRB- CXCR3 -LRB- + -RRB- cells are present in mice , CD8 -LRB- + -RRB- CXCR3 -LRB- + -RRB- cells , but not CD8 -LRB- + -RRB- CD122 -LRB- + -RRB- cells , are present in humans .
19609979	0	CD122	62,67	CXCR3	10,15	CD122	CXCR3	16185(Tax:10090)	12766(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY function|nmod|Treg have|dobj|function have|nsubj|cells cells|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
21264308	0	CD123	42,47	BDCA2	49,54	CD123	BDCA2	3563	170482	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|compound|END_ENTITY	Expression of the T cell receptor ab on a CD123 + BDCA2 + HLA-DR + subpopulation in head and neck_squamous_cell_carcinoma .
26748017	0	CD123	143,148	CD131	152,157	CD123	CD131	3563	1439	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Auger electron-emitting -LRB- 111 -RRB- In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute_myeloid_leukemia -LRB- AML -RRB- cells displaying the CD123 -LRB- + -RRB- / CD131 -LRB- - -RRB- phenotype of leukemia stem cells .
18415658	0	CD123	42,47	CD34	30,34	CD123	CD34	3563	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	HERG K + channel expression in CD34 + / CD38 - / CD123 -LRB- high -RRB- cells and primary leukemia cells and analysis of its regulation in leukemia cells .
21933861	0	CD123	29,34	CD34	15,19	CD123	CD34	3563	947	Gene	Gene	+|compound|START_ENTITY blasts|nummod|+ /|dep|blasts /|compound|END_ENTITY	High levels of CD34 + CD38low / - CD123 + blasts are predictive of an adverse outcome in acute_myeloid_leukemia : a Groupe Ouest-Est des Leucemies Aigues et Maladies du Sang -LRB- GOELAMS -RRB- study .
24598641	0	CD123	27,32	CD34	1,5	CD123	CD34	3563	947	Gene	Gene	overexpression|compound|START_ENTITY cells|nmod|overexpression cells|nummod|END_ENTITY	-LSB- CD34 -LRB- + -RRB- CD19 -LRB- + -RRB- cells with CD123 overexpression are a novel prognostic marker in Ph chromosome-positive acute_lymphoblastic_leukemia -RSB- .
24846193	0	CD123	21,26	CD34	10,14	CD123	CD34	3563	947	Gene	Gene	cells|nummod|START_ENTITY CD38|dep|cells CD38|compound|END_ENTITY	Increased CD34 + CD38 - CD123 + cells in myelodysplastic_syndrome displaying malignant features similar to those in AML .
18415658	0	CD123	42,47	CD38	36,40	CD123	CD38	3563	952	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	HERG K + channel expression in CD34 + / CD38 - / CD123 -LRB- high -RRB- cells and primary leukemia cells and analysis of its regulation in leukemia cells .
24846193	0	CD123	21,26	CD38	15,19	CD123	CD38	3563	952	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dep|cells	Increased CD34 + CD38 - CD123 + cells in myelodysplastic_syndrome displaying malignant features similar to those in AML .
19730083	0	CD123	19,24	CD68	14,18	CD123	CD68	3563	968	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Plasmacytoid -LRB- CD68 + CD123 + -RRB- monocytes may play a crucial role in the pathogenesis of hydroa vacciniforme : a case report .
21282962	0	CD123	39,44	CD68	33,37	CD123	CD68	3563	968	Gene	Gene	+|compound|START_ENTITY cells|compound|+ accumulation|dep|cells accumulation|nmod|END_ENTITY	Allergen-induced accumulation of CD68 - , CD123 + dendritic cells in the nasal mucosa .
11726317	0	CD123	36,41	Interleukin-3	0,13	CD123	Interleukin-3	3563	3562	Gene	Gene	chain|appos|START_ENTITY chain|compound|END_ENTITY	Interleukin-3 receptor alpha chain -LRB- CD123 -RRB- is widely expressed in hematologic_malignancies .
26474588	0	CD123	32,37	Interleukin-3	0,13	CD123	Interleukin-3	3563	3562	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Interleukin-3 receptor a chain -LRB- CD123 -RRB- is preferentially expressed in immature T-ALL and may not associate with outcomes of chemotherapy .
10460618	0	CD126	18,23	CD130	0,5	CD126	CD130	3570	3572	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	CD130 rather than CD126 expression is associated with disease activity in multiple_myeloma .
18576316	0	CD127	83,88	CD25	13,17	CD127	CD25	3575	3559	Gene	Gene	CD4|nummod|START_ENTITY sensitivity|nmod|CD4 +|dep|sensitivity +|appos|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
19667968	0	CD127	0,5	CD25	29,33	CD127	CD25	3575	3669	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	CD127 -LRB- low -RRB- expression in CD4 + CD25 -LRB- high -RRB- T cells as immune biomarker of renal function in transplant patients .
21413939	0	CD127	34,39	CD25	92,96	CD127	CD25	3575	3559	Gene	Gene	forkhead_box_P3|compound|START_ENTITY matures|dobj|forkhead_box_P3 T|dep|matures T|nmod|FoxP3 FoxP3|compound|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	CD127	83,88	CD25	92,96	CD127	CD25	3575	3559	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|compound|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21799858	0	CD127	100,105	CD25	107,111	CD127	CD25	3575	3559	Gene	Gene	+|nmod|START_ENTITY +|parataxis|generated generated|nsubj|cells cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
22734240	0	CD127	64,69	CD25	58,62	CD127	CD25	3575	3559	Gene	Gene	significance|dep|START_ENTITY significance|nmod|END_ENTITY	-LSB- Clinical significance and detection of the expression of CD25 - CD127 - on CD4 + T cells in peripheral blood in patients with hepatitis_B -RSB- .
23257455	0	CD127	26,31	CD25	19,23	CD127	CD25	16197(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	-LSB- Analysis of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- Treg cells in mice -RSB- .
23466550	0	CD127	45,50	CD25	35,39	CD127	CD25	3575	3669	Gene	Gene	START_ENTITY|nsubj|Impact Impact|nmod|medium medium|nmod|END_ENTITY	Impact of culture medium on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- lo/neg -RRB- Treg expansion for the purpose of clinical application .
26333292	0	CD127	27,32	CD25	19,23	CD127	CD25	3575	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|amod|Decrease Decrease|nmod|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
17173927	0	CD127	85,90	CD4	6,9	CD127	CD4	3575	920	Gene	Gene	chain|appos|START_ENTITY levels|nmod|chain express|dobj|levels +|ccomp|express +|nsubj|END_ENTITY	Human CD4 + regulatory T cells express lower levels of the IL-7 receptor alpha chain -LRB- CD127 -RRB- , allowing consistent identification and sorting of live cells .
18390743	0	CD127	0,5	CD4	34,37	CD127	CD4	3575	920	Gene	Gene	defines|nsubj|START_ENTITY defines|dobj|subsets subsets|compound|END_ENTITY	CD127 and CD25 expression defines CD4 + T cell subsets that are differentially depleted during HIV_infection .
18406576	0	CD127	0,5	CD4	41,44	CD127	CD4	3575	920	Gene	Gene	immunophenotyping|compound|START_ENTITY suggests|nsubj|immunophenotyping suggests|dobj|regulation regulation|compound|END_ENTITY	CD127 immunophenotyping suggests altered CD4 + T cell regulation in primary progressive multiple_sclerosis .
18576316	0	CD127	83,88	CD4	8,11	CD127	CD4	3575	920	Gene	Gene	CD4|nummod|START_ENTITY sensitivity|nmod|CD4 +|dep|sensitivity +|compound|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
20690182	0	CD127	10,15	CD4	46,49	CD127	CD4	3575	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Increased CD127 expression on activated FOXP3 + CD4 + regulatory T cells .
20935556	0	CD127	8,13	CD4	39,42	CD127	CD4	3575	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Reduced CD127 expression on peripheral CD4 + T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapy .
21799858	0	CD127	100,105	CD4	23,26	CD127	CD4	3575	920	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21802372	0	CD127	65,70	CD4	52,55	CD127	CD4	3575	920	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Identification of FOXP3-negative regulatory T-like -LRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- -RRB- cells in patients with immune_dysregulation , _ polyendocrinopathy , _ enteropathy , _ X-linked_syndrome .
22122423	0	CD127	62,67	CD4	30,33	CD127	CD4	3575	920	Gene	Gene	expression|compound|START_ENTITY defined|nmod|expression subsets|acl|defined T|dobj|subsets T|nsubj|Changes Changes|nmod|proportions proportions|nmod|END_ENTITY	Changes in the proportions of CD4 -LRB- + -RRB- T cell subsets defined by CD127 and CD25 expression during HBV_infection .
23257455	0	CD127	26,31	CD4	13,16	CD127	CD4	16197(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Analysis of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- Treg cells in mice -RSB- .
23466550	0	CD127	45,50	CD4	28,31	CD127	CD4	3575	920	Gene	Gene	START_ENTITY|nsubj|Impact Impact|nmod|medium medium|nmod|CD25 CD25|compound|END_ENTITY	Impact of culture medium on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- lo/neg -RRB- Treg expansion for the purpose of clinical application .
24348676	0	CD127	10,15	CD4	30,33	CD127	CD4	3575	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T-cells T-cells|compound|END_ENTITY	Decreased CD127 expression on CD4 + T-cells and elevated frequencies of CD4 + CD25 + CD127 - T-cells in children with long-lasting type_1_diabetes .
26333292	0	CD127	27,32	CD4	12,15	CD127	CD4	3575	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|amod|Decrease Decrease|nmod|CD25 CD25|compound|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
16487237	0	CD127	0,5	CD8	58,61	CD127	CD8	3575	925	Gene	Gene	expression|compound|START_ENTITY altered|nsubjpass|expression altered|nmod|cells cells|compound|END_ENTITY	CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients -- reversal by highly active anti-retroviral therapy -LRB- HAART -RRB- .
16537621	0	CD127	54,59	CD8	79,82	CD127	CD8	3575	925	Gene	Gene	interleukin-7_receptor_alpha_chain|appos|START_ENTITY interleukin-7_receptor_alpha_chain|nmod|cells cells|compound|END_ENTITY	Expression of the interleukin-7_receptor_alpha_chain -LRB- CD127 -RRB- on virus-specific CD8 + T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis_B_virus infection .
17152014	0	CD127	40,45	CD8	57,60	CD127	CD8	3575	925	Gene	Gene	memory|compound|START_ENTITY END_ENTITY|nsubj|memory	Functionally competent antigen-specific CD127 -LRB- hi -RRB- memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatment .
17956896	0	CD127	82,87	CD8	97,100	CD127	CD8	3575	925	Gene	Gene	shedding|nmod|START_ENTITY induces|dobj|shedding induces|nmod|cells cells|compound|END_ENTITY	IL-7 decreases IL-7 receptor alpha -LRB- CD127 -RRB- expression and induces the shedding of CD127 by human CD8 + T cells .
18717263	0	CD127	33,38	CD8	94,97	CD127	CD8	3575	925	Gene	Gene	survival|appos|START_ENTITY expression|nmod|survival Altered|dep|expression Altered|dep|lymphocytes lymphocytes|compound|END_ENTITY	-LSB- Altered expression of survival -LRB- CD127 -RRB- and death -LRB- Fas -RRB- receptors in total , na ve and memory CD8 T lymphocytes from human immunodeficiency virus_infected patients : possible implications for progression of infection -RSB- .
19011158	0	CD127	70,75	CD8	66,69	CD127	CD8	3575	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
19147839	0	CD127	66,71	CD8	86,89	CD127	CD8	3575	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells .
19350559	0	CD127	12,17	CD8	73,76	CD127	CD8	3575	925	Gene	Gene	down-regulation|compound|START_ENTITY correlates|nsubj|down-regulation correlates|nmod|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	Progressive CD127 down-regulation correlates with increased apoptosis of CD8 T cells during chronic_HIV-1_infection .
20130059	0	CD127	164,169	CD8	118,121	CD127	CD8	3575	925	Gene	Gene	alpha|appos|START_ENTITY defined|nmod|alpha cells|acl|defined cells|compound|END_ENTITY	Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R -LCB- alpha -RCB- -LRB- CD127 -RRB- and perforin expression .
20807412	0	CD127	20,25	CD8	47,50	CD127	CD8	3575	925	Gene	Gene	expression|nummod|START_ENTITY analysis|nmod|expression END_ENTITY|nsubj|analysis	Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic_hepatitis_B during telbivudine treatment .
21740271	0	CD127	48,53	CD8	68,71	CD127	CD8	3575	925	Gene	Gene	expression|compound|START_ENTITY alters|dobj|expression alters|nmod|END_ENTITY	In vitro HIV_Type_1 infection indirectly alters CD127 expression on CD8 -LRB- + -RRB- T cells .
23965471	0	CD127	132,137	CD8	66,69	CD127	CD8	3575	925	Gene	Gene	downregulation|nmod|START_ENTITY increased|nmod|downregulation increased|nmod|cells cells|compound|END_ENTITY	HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127 .
25231631	0	CD127	99,104	CD8	62,65	CD127	CD8	3575	925	Gene	Gene	expression|compound|START_ENTITY characterized|nmod|expression cells|acl|characterized subset|dep|cells subset|nmod|END_ENTITY	Human bone marrow contains a subset of quiescent early memory CD8 -LRB- + -RRB- T cells characterized by high CD127 expression and efflux capacity .
25986373	0	CD127	49,54	CD8	64,67	CD127	CD8	3575	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat 's Basic Region .
25986373	0	CD127	49,54	CD8	64,67	CD127	CD8	3575	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat 's Basic Region .
26272555	0	CD127	46,51	CD8	114,117	CD127	CD8	3575	925	Gene	Gene	endocytosis|nmod|START_ENTITY induces|dobj|endocytosis induces|nmod|proteasome proteasome|nmod|cells cells|compound|END_ENTITY	IL-7 induces clathrin-mediated endocytosis of CD127 and subsequent degradation by the proteasome in primary human CD8 T cells .
20690182	0	CD127	10,15	FOXP3	40,45	CD127	FOXP3	3575	50943	Gene	Gene	expression|compound|START_ENTITY expression|nmod|CD4 CD4|compound|END_ENTITY	Increased CD127 expression on activated FOXP3 + CD4 + regulatory T cells .
21799858	0	CD127	100,105	FOXP3	113,118	CD127	FOXP3	3575	50943	Gene	Gene	+|nmod|START_ENTITY +|parataxis|generated generated|nsubj|cells cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
23019018	0	CD127	9,14	FOXP3	56,61	CD127	FOXP3	3575	50943	Gene	Gene	START_ENTITY|dep|assessment assessment|nmod|phenotype phenotype|nmod|cells cells|nummod|END_ENTITY	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
16818678	0	CD127	0,5	FoxP3	43,48	CD127	FoxP3	3575	50943	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + T reg cells .
21413939	0	CD127	34,39	FoxP3	103,108	CD127	FoxP3	3575	50943	Gene	Gene	forkhead_box_P3|compound|START_ENTITY matures|dobj|forkhead_box_P3 T|dep|matures T|nmod|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	CD127	34,39	FoxP3	60,65	CD127	FoxP3	3575	50943	Gene	Gene	forkhead_box_P3|compound|START_ENTITY forkhead_box_P3|appos|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	CD127	83,88	FoxP3	60,65	CD127	FoxP3	3575	50943	Gene	Gene	FoxP3|amod|START_ENTITY T|nmod|FoxP3 T|dep|matures matures|dobj|forkhead_box_P3 forkhead_box_P3|appos|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
22989355	0	CD127	168,173	FoxP3	213,218	CD127	FoxP3	3575	50943	Gene	Gene	START_ENTITY|nmod|alternative alternative|nmod|END_ENTITY	Flow cytometric immunophenotyping of regulatory T cells in chronic_lymphocytic_leukemia : comparative assessment of various markers and use of novel antibody panel with CD127 as alternative to transcription factor FoxP3 .
20332626	0	CD127	36,41	Foxp3	30,35	CD127	Foxp3	3575	50943	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Defective circulating CD4CD25 + Foxp3 + CD127 -LRB- low -RRB- regulatory T-cells in patients with chronic_heart_failure .
19011158	0	CD127	70,75	IL-2	0,4	CD127	IL-2	3575	3558	Gene	Gene	+|compound|START_ENTITY regulate|dobj|+ regulate|nsubj|cytokines cytokines|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
20201040	0	CD127	28,33	Interleukin-4	0,13	CD127	Interleukin-4	3575	3565	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8 + T cells .
19900372	0	CD127	51,56	PD-1	16,20	CD127	PD-1	3575	5133	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Association of PD-1 expression on CD4 + CD25 nt/hi CD127 lo regulatory T cells with disease progression in HIV-1_infected patients -RSB- .
19011158	0	CD127	70,75	gamma_chain	14,25	CD127	gamma chain	3575	3561	Gene	Gene	+|compound|START_ENTITY regulate|dobj|+ regulate|nsubj|cytokines cytokines|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
25246708	0	CD13	10,14	ADAM17	56,62	CD13	ADAM17	290	6868	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Targeting CD13 -LRB- aminopeptidase-N -RRB- in turn downregulates ADAM17 by internalization in acute_myeloid_leukaemia cells .
9257688	0	CD13	43,47	APN	38,41	CD13	APN	290	290	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	The activation-dependent induction of APN - -LRB- CD13 -RRB- in T-cells is controlled at different levels of gene expression .
18366676	0	CD13	23,27	Aminopeptidase_N	0,16	CD13	Aminopeptidase N	290	290	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|dep|inhibitor	Aminopeptidase_N -LRB- APN -RRB- / CD13 inhibitor , Ubenimex , enhances radiation sensitivity in human cervical_cancer .
8659452	0	CD13	17,21	CD14	23,27	CD13	CD14	290	929	Gene	Gene	expression|dep|START_ENTITY expression|appos|END_ENTITY	Myeloid antigen , CD13 , CD14 , and/or CD33 expression is restricted to certain lymphoid_neoplasms .
1379402	0	CD13	13,17	CD33	6,10	CD13	CD33	290	945	Gene	Gene	CD4|dep|START_ENTITY CD4|nummod|END_ENTITY	CD4 + , CD33 - , CD13 - , CD14 - acute_monoblastic_leukaemia .
17339183	0	CD13	32,36	CD33	44,48	CD13	CD33	290	945	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Absence of prognostic impact of CD13 and/or CD33 antigen expression in adult acute_lymphoblastic_leukemia .
8659452	0	CD13	17,21	CD33	36,40	CD13	CD33	290	945	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Myeloid antigen , CD13 , CD14 , and/or CD33 expression is restricted to certain lymphoid_neoplasms .
9335320	0	CD13	22,26	CD33	27,31	CD13	CD33	290	945	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expansion of CD13 + CD33 + dendritic cell precursors from multipotent progenitors is regulated by a discrete fas-mediated apoptotic schedule .
10498605	0	CD13	135,139	CD34	84,88	CD13	CD34	290	947	Gene	Gene	aminopeptidase|dobj|START_ENTITY aminopeptidase|nsubj|Demonstration Demonstration|dep|arise arise|nmod|population population|acl:relcl|END_ENTITY	Demonstration that human mast cells arise from a progenitor cell population that is CD34 -LRB- + -RRB- , c-kit -LRB- + -RRB- , and expresses aminopeptidase N -LRB- CD13 -RRB- .
11940478	0	CD13	27,31	CD34	20,24	CD13	CD34	290	947	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Characterization of CD34 + , CD13 + , CD33 - cells , a rare subset of immature human hematopoietic cells .
20489139	0	CD13	13,17	CD34	8,12	CD13	CD34	16790(Tax:10090)	12490(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Myeloid CD34 + CD13 + precursor cells transdifferentiate into chondrocyte-like cells in atherosclerotic intimal calcification .
18467109	0	CD13	81,85	amino-peptidase_N	63,80	CD13	amino-peptidase N	290	290	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis , and QSAR studies of novel lysine derives as amino-peptidase_N / CD13 inhibitors .
14679016	0	CD13	44,48	aminopeptidase_N	27,43	CD13	aminopeptidase N	290	290	Gene	Gene	significance|dep|START_ENTITY significance|nmod|END_ENTITY	Biological significance of aminopeptidase_N / CD13 in thyroid_carcinomas .
15138629	0	CD13	66,70	aminopeptidase_N	49,65	CD13	aminopeptidase N	290	290	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	IL-10 and TGF-beta differ in their regulation of aminopeptidase_N / CD13 expression in monocytes .
22307623	0	CD13	41,45	aminopeptidase_N	23,39	CD13	aminopeptidase N	16790(Tax:10090)	16790(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Cooperative effects of aminopeptidase_N -LRB- CD13 -RRB- expressed by nonmalignant and cancer cells within the tumor microenvironment .
7829125	0	CD13	31,35	aminopeptidase_N	14,30	CD13	aminopeptidase N	290	290	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of aminopeptidase_N / CD13 in tumour-infiltrating lymphocytes from human renal_cell_carcinoma .
7904539	0	CD13	36,40	aminopeptidase_N	18,34	CD13	aminopeptidase N	290	290	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the aminopeptidase_N -LRB- CD13 -RRB- gene in the human T cell lines HuT78 and H9 .
1378163	0	CD13	132,136	c-kit	0,5	CD13	c-kit	290	3815	Gene	Gene	expression|nmod|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|amod|END_ENTITY	c-kit gene expression in CD7-positive acute_lymphoblastic_leukemia : close correlation with expression of myeloid-associated antigen CD13 .
10460618	0	CD130	0,5	CD126	18,23	CD130	CD126	3572	3570	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	CD130 rather than CD126 expression is associated with disease activity in multiple_myeloma .
26748017	0	CD131	152,157	CD123	143,148	CD131	CD123	1439	3563	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Auger electron-emitting -LRB- 111 -RRB- In-DTPA-NLS-CSL360 radioimmunoconjugates are cytotoxic to human acute_myeloid_leukemia -LRB- AML -RRB- cells displaying the CD123 -LRB- + -RRB- / CD131 -LRB- - -RRB- phenotype of leukemia stem cells .
11246656	0	CD132	61,66	common_cytokine_receptor_gamma_chain	23,59	CD132	common cytokine receptor gamma chain	3561	3561	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abundant expression of common_cytokine_receptor_gamma_chain -LRB- CD132 -RRB- in rheumatoid_joints .
23290300	0	CD133	95,100	ABCG2	102,107	CD133	ABCG2	60357(Tax:10116)	312382(Tax:10116)	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133 + ABCG2 + CXCR4 + mesenchymal stem cells : development of autologous cell-based therapeutics for traumatic_brain_injury .
23438193	0	CD133	80,85	ABCG2	33,38	CD133	ABCG2	8842	9429	Gene	Gene	resistance|nmod|START_ENTITY END_ENTITY|nmod|resistance	Positive correlation of Oct4 and ABCG2 to chemotherapeutic resistance in CD90 -LRB- + -RRB- CD133 -LRB- + -RRB- liver_cancer stem cells .
23803205	0	CD133	1,6	ALDH1	65,70	CD133	ALDH1	8842	216	Gene	Gene	express|nsubj|START_ENTITY express|dobj|levels levels|nmod|END_ENTITY	-LSB- CD133 -LRB- + -RRB- Colo205 colorectal_cancer cells express high levels of ALDH1 in serum-free culture -RSB- .
25576341	0	CD133	54,59	ALDH1	48,53	CD133	ALDH1	8842	216	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	microRNA-143 is associated with the survival of ALDH1 + CD133 + osteosarcoma cells and the chemoresistance of osteosarcoma .
26298632	0	CD133	67,72	ALDH1	74,79	CD133	ALDH1	8842	216	Gene	Gene	expressions|appos|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
23962788	0	CD133	28,33	Androgen_receptor	0,17	CD133	Androgen receptor	8842	367	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Androgen_receptor increases CD133 expression and progenitor-like population that associate with cisplatin resistance in endometrial_cancer cell line .
24630518	0	CD133	27,32	B7-H3	18,23	CD133	B7-H3	8842	80381	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Overexpression of B7-H3 in CD133 + colorectal_cancer cells is associated with cancer progression and survival in human patients .
19521665	0	CD133	62,67	CD111	111,116	CD133	CD111	8842	5818	Gene	Gene	cells|nummod|START_ENTITY cells|acl:relcl|express express|dobj|END_ENTITY	Engineered_herpes_simplex_viruses_efficiently_infect and kill CD133 + human glioma xenograft cells that express CD111 .
25045527	0	CD133	59,64	CD117	52,57	CD133	CD117	8842	3815	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	Recruitment and retention of human autologous CD34 + CD117 + CD133 + bone marrow stem cells to infarcted_myocardium followed by directed vasculogenesis : Novel strategy for cardiac regeneration .
16530743	0	CD133	14,19	CD133	32,37	CD133	CD133	8842	8842	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	Generation of CD133 + cells from CD133 - peripheral blood mononuclear cells and their properties .
16530743	0	CD133	32,37	CD133	14,19	CD133	CD133	8842	8842	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	Generation of CD133 + cells from CD133 - peripheral blood mononuclear cells and their properties .
18836486	0	CD133	25,30	CD133	53,58	CD133	CD133	8842	8842	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|cells cells|compound|END_ENTITY	Epigenetic regulation of CD133 and tumorigenicity of CD133 + ovarian_cancer cells .
18836486	0	CD133	53,58	CD133	25,30	CD133	CD133	8842	8842	Gene	Gene	cells|compound|START_ENTITY regulation|nmod|cells regulation|nmod|END_ENTITY	Epigenetic regulation of CD133 and tumorigenicity of CD133 + ovarian_cancer cells .
21122138	0	CD133	25,30	CD133	53,58	CD133	CD133	8842	8842	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|cells cells|compound|END_ENTITY	Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial_cancer cells .
21122138	0	CD133	53,58	CD133	25,30	CD133	CD133	8842	8842	Gene	Gene	cells|compound|START_ENTITY regulation|nmod|cells regulation|nmod|END_ENTITY	Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial_cancer cells .
21803487	0	CD133	68,73	CD15	75,79	CD133	CD15	8842	2526	Gene	Gene	compartment|compound|START_ENTITY compartment|compound|END_ENTITY	Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133 + / CD15 + cell compartment and the in vitro tumorigenic capability of neuroblastoma cells .
23197865	0	CD133	0,5	CD166	8,13	CD133	CD166	8842	214	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
26298632	0	CD133	67,72	CD24	55,59	CD133	CD24	8842	100133941	Gene	Gene	expressions|appos|START_ENTITY expressions|compound|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
11359674	0	CD133	0,5	CD34	43,47	CD133	CD34	8842	947	Gene	Gene	selection|nummod|START_ENTITY expansion|nsubj|selection expansion|amod|alternative alternative|nmod|selection selection|compound|END_ENTITY	CD133 + cell selection is an alternative to CD34 + cell selection for ex vivo expansion of hematopoietic stem cells .
15910245	0	CD133	48,53	CD34	42,46	CD133	CD34	8842	947	Gene	Gene	hematopoietic|compound|START_ENTITY hematopoietic|compound|END_ENTITY	Differential gene expression profiling of CD34 + CD133 + umbilical cord blood hematopoietic stem progenitor cells .
16110028	0	CD133	19,24	CD34	12,16	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Circulating CD34 + , CD133 + , and vascular_endothelial_growth_factor_receptor_2-positive endothelial progenitor cells in myelofibrosis_with_myeloid_metaplasia .
16439688	0	CD133	6,11	CD34	0,4	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY END_ENTITY|parataxis|+	CD34 - / CD133 + / VEGFR-2 + endothelial progenitor cell subpopulation with potent vasoregenerative capacities .
16698211	0	CD133	6,11	CD34	0,4	CD133	CD34	60357(Tax:10116)	305081(Tax:10116)	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	CD34 + / CD133 - circulating endothelial precursor cells -LRB- CEP -RRB- : characterization , senescence and in vivo application .
17492259	0	CD133	13,18	CD34	7,11	CD133	CD34	8842	947	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	Viable CD34 + / CD133 + blood progenitor cell dose as a predictor of haematopoietic engraftment in multiple_myeloma patients undergoing autologous peripheral blood stem cell transplantation .
17559657	0	CD133	44,49	CD34	51,55	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY involved|nmod|+ pathways|acl|involved pathways|parataxis|progenitor progenitor|nsubj|+ +|compound|END_ENTITY	Common molecular pathways involved in human CD133 + / CD34 + progenitor cell expansion and cancer .
17765649	0	CD133	28,33	CD34	22,26	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
18410526	0	CD133	34,39	CD34	40,44	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells from cord blood CD133 + CD34 + progenitors share phenotypic , functional and gene expression profile similarities with lymphatics .
18811243	0	CD133	47,52	CD34	54,58	CD133	CD34	8842	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cord blood-derived neurons are originated from CD133 + / CD34 stem/progenitor cells in a cell-to-cell contact dependent manner .
19024325	0	CD133	76,81	CD34	83,87	CD133	CD34	8842	947	Gene	Gene	immunophenotype|nummod|START_ENTITY immunophenotype|nummod|END_ENTITY	-LSB- Multiparametric flow cytometry analyzes the expressions of immunophenotype CD133 , CD34 , CD44 in lung_cancer naive cells -RSB- .
19380281	0	CD133	47,52	CD34	23,27	CD133	CD34	8842	947	Gene	Gene	cells|nummod|START_ENTITY number|dep|cells number|nmod|+ +|compound|END_ENTITY	Differential number of CD34 + , CD133 + and CD34 + / CD133 + cells in peripheral blood of patients with congestive_heart_failure .
19956906	0	CD133	90,95	CD34	84,88	CD133	CD34	8842	947	Gene	Gene	+|nsubj|START_ENTITY enhance|parataxis|+ enhance|dobj|migration migration|nmod|END_ENTITY	Insulin-like_growth_factor_binding_proteins-2_and _ -4 enhance the migration of human CD34 - / CD133 + hematopoietic stem and progenitor cells .
20213459	0	CD133	0,5	CD34	6,10	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD133 + CD34 + stem cells are mobilized after musculoskeletal surgery and target endothelium activated by surgical wound fluid .
21715308	0	CD133	44,49	CD34	24,28	CD133	CD34	8842	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adult human circulating CD34 Lin CD45 CD133 cells can differentiate into hematopoietic and endothelial cells .
22386660	0	CD133	0,5	CD34	6,10	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD133 + CD34 + and CD133 + CD38 + blood progenitor cells as predictors of platelet engraftment in patients undergoing autologous peripheral blood stem cell transplantation .
22480576	0	CD133	34,39	CD34	40,44	CD133	CD34	8842	947	Gene	Gene	CD45|compound|START_ENTITY CD45|compound|END_ENTITY	Isolation and characterization of CD133 + CD34 + VEGFR-2 + CD45 - fetal endothelial cells from human term placenta .
22543333	0	CD133	46,51	CD34	53,57	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY labeling|nmod|+ labeling|parataxis|stem stem|nsubj|+ +|compound|END_ENTITY	Clinical labeling and imaging of transplanted CD133 + / CD34 + stem cells in patients with ischemic_heart_disease .
22855739	0	CD133	21,26	CD34	28,32	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY positive|dep|+ Osteocalcin|dep|positive Osteocalcin|parataxis|END_ENTITY	Osteocalcin positive CD133 + / CD34 - / KDR + progenitor cells as an independent marker for unstable atherosclerosis .
23097560	0	CD133	43,48	CD34	37,41	CD133	CD34	8842	947	Gene	Gene	cells|compound|START_ENTITY increase|nsubj|cells injection|parataxis|increase injection|nmod|+ +|compound|END_ENTITY	Intrablastocyst injection with human CD34 + / CD133 + cells increase survival of immunocompetent fumarylacetoacetate_hydrolase knockout mice .
23135476	0	CD133	44,49	CD34	51,55	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY markers|nmod|+ MicroRNAs|nmod|markers MicroRNAs|parataxis|stem stem|nsubj|+ +|compound|END_ENTITY	MicroRNAs as markers for neurally committed CD133 + / CD34 + stem cells derived from human umbilical cord blood .
24335569	0	CD133	79,84	CD34	74,78	CD133	CD34	8842	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Inverse correlation between circulating endothelial progenitor cells with CD34 + CD133 + and the severity of coronary_atherosclerosis assessed by Syntax score .
24335569	5	CD133	621,626	CD34	614,618	CD133	CD34	8842	947	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	The percentage of CD34 -LRB- + -RRB- CD133 -LRB- + -RRB- cells in the mononuclear cells isolated from peripheral blood of different groups by flow cytometric analysis was compared .
25045527	0	CD133	59,64	CD34	46,50	CD133	CD34	8842	947	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	Recruitment and retention of human autologous CD34 + CD117 + CD133 + bone marrow stem cells to infarcted_myocardium followed by directed vasculogenesis : Novel strategy for cardiac regeneration .
25444027	0	CD133	12,17	CD34	19,23	CD133	CD34	8842	947	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Circulating CD133 + CD34 + Progenitor Cells and Plasma Stromal-Derived Factor-1Alpha : Predictive Role in Ischemic_Stroke Patients .
27016273	0	CD133	29,34	CD34	46,50	CD133	CD34	8842	947	Gene	Gene	CD45RA|compound|START_ENTITY frequency|nmod|CD45RA END_ENTITY|nsubj|frequency	The frequency of multipotent CD133 -LRB- + -RRB- CD45RA -LRB- - -RRB- CD34 -LRB- + -RRB- hematopoietic stem cells is not increased in fetal liver compared to adult stem cell sources .
19024325	0	CD133	76,81	CD44	89,93	CD133	CD44	8842	960	Gene	Gene	immunophenotype|nummod|START_ENTITY immunophenotype|nummod|END_ENTITY	-LSB- Multiparametric flow cytometry analyzes the expressions of immunophenotype CD133 , CD34 , CD44 in lung_cancer naive cells -RSB- .
19711346	0	CD133	52,57	CD44	58,62	CD133	CD44	8842	960	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Cancer stem/progenitor cells are highly enriched in CD133 + CD44 + population in hepatocellular_carcinoma .
20526812	0	CD133	0,5	CD44	7,11	CD133	CD44	8842	960	Gene	Gene	subgroups|compound|START_ENTITY subgroups|compound|END_ENTITY	CD133 + CD44 + subgroups may be human small intestinal stem cells .
20937222	0	CD133	47,52	CD44	53,57	CD133	CD44	8842	960	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The study of the tumor stem cell properties of CD133 + CD44 + cells in the human lung_adenocarcinoma cell line A549 .
20948317	0	CD133	6,11	CD44	0,4	CD133	CD44	8842	960	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CD44 + CD133 + population exhibits cancer stem cell-like characteristics in human gallbladder_carcinoma .
21750907	0	CD133	16,21	CD44	61,65	CD133	CD44	8842	960	Gene	Gene	CD44|nsubj|START_ENTITY CD44|nmod|END_ENTITY	Highly enriched CD133 -LRB- + -RRB- CD44 -LRB- + -RRB- stem-like cells with CD133 -LRB- + -RRB- CD44 -LRB- high -RRB- metastatic subset in HCT116 colon_cancer cells .
21750907	0	CD133	53,58	CD44	24,28	CD133	CD44	8842	960	Gene	Gene	CD44|compound|START_ENTITY END_ENTITY|nmod|CD44	Highly enriched CD133 -LRB- + -RRB- CD44 -LRB- + -RRB- stem-like cells with CD133 -LRB- + -RRB- CD44 -LRB- high -RRB- metastatic subset in HCT116 colon_cancer cells .
22740326	0	CD133	17,22	CD44	26,30	CD133	CD44	8842	960	Gene	Gene	Co-expression|nmod|START_ENTITY Co-expression|dep|+ +|compound|END_ENTITY	Co-expression of CD133 -LRB- + -RRB- / CD44 -LRB- + -RRB- in human colon_cancer and liver metastasis .
23036582	0	CD133	0,5	CD44	9,13	CD133	CD44	8842	960	Gene	Gene	isolated|nsubj|START_ENTITY isolated|parataxis|END_ENTITY	CD133 -LRB- + -RRB- / CD44 -LRB- + -RRB- / Oct4 -LRB- + -RRB- / Nestin -LRB- + -RRB- stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic_cancer .
23197865	0	CD133	0,5	CD44	14,18	CD133	CD44	8842	960	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
23252868	0	CD133	54,59	CD44	61,65	CD133	CD44	8842	960	Gene	Gene	ALDH1|nummod|START_ENTITY ALDH1|dep|END_ENTITY	Expression of the potential cancer stem cell markers , CD133 , CD44 , ALDH1 , and b-catenin , in primary lung_adenocarcinoma -- their prognostic significance .
23811539	0	CD133	42,47	CD44	51,55	CD133	CD44	8842	960	Gene	Gene	START_ENTITY|dep|subpopulation subpopulation|amod|END_ENTITY	Fibronectin extra_domain_A -LRB- EDA -RRB- sustains CD133 -LRB- + -RRB- / CD44 -LRB- + -RRB- subpopulation of colorectal_cancer cells .
24178866	0	CD133	6,11	CD44	0,4	CD133	CD44	8842	960	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD44 + / CD133 + immunophenotype and matrix_metalloproteinase-9 : Influence on prognosis in early-stage oral_squamous_cell_carcinoma .
24760019	0	CD133	39,44	CD44	46,50	CD133	CD44	8842	960	Gene	Gene	CD24|compound|START_ENTITY CD24|appos|END_ENTITY	Evaluation of cancer stem cell markers CD133 , CD44 , CD24 : association with AKT isoforms and radiation resistance in colon_cancer cells .
24932297	0	CD133	78,83	CD44	90,94	CD133	CD44	8842	960	Gene	Gene	formation|nmod|START_ENTITY signaling|nmod|formation cell|acl|signaling profiling|nmod|cell profiling|parataxis|prostate_cancer prostate_cancer|nsubj|END_ENTITY	Expression profiling of stem cell signaling alters with spheroid formation in CD133 -LRB- high -RRB- / CD44 -LRB- high -RRB- prostate_cancer stem cells .
26298632	0	CD133	67,72	CD44	61,65	CD133	CD44	8842	960	Gene	Gene	expressions|appos|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
26318819	0	CD133	112,117	CD44	119,123	CD133	CD44	19126(Tax:10090)	12505(Tax:10090)	Gene	Gene	EpCAM|dep|START_ENTITY EpCAM|dep|END_ENTITY	LNA aptamer based multi-modal , Fe3O4-saturated_lactoferrin -LRB- Fe3O4-bLf -RRB- nanocarriers for triple positive -LRB- EpCAM , CD133 , CD44 -RRB- colon_tumor targeting and NIR , MRI and CT imaging .
21715308	0	CD133	44,49	CD45	37,41	CD133	CD45	8842	5788	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adult human circulating CD34 Lin CD45 CD133 cells can differentiate into hematopoietic and endothelial cells .
19272160	0	CD133	85,90	COX-2	65,70	CD133	COX-2	19126(Tax:10090)	17709(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133 + U87 glioblastoma cells .
17765649	0	CD133	28,33	CXCR4	158,163	CD133	CXCR4	8842	7852	Gene	Gene	+|compound|START_ENTITY Mobilization|nmod|+ stem|nsubj|Mobilization stem|nmod|consumption consumption|nmod|expression expression|dep|related related|nmod|modulation modulation|nmod|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
23290300	0	CD133	95,100	CXCR4	108,113	CD133	CXCR4	60357(Tax:10116)	60628(Tax:10116)	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133 + ABCG2 + CXCR4 + mesenchymal stem cells : development of autologous cell-based therapeutics for traumatic_brain_injury .
26141860	0	CD133	38,43	CXCR4	45,50	CD133	CXCR4	8842	7852	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Microenvironment-Modulated Metastatic CD133 + / CXCR4 + / EpCAM - Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis .
26466742	0	CD133	42,47	CXCR4	14,19	CD133	CXCR4	8842	7852	Gene	Gene	cells|nummod|START_ENTITY blood-derived|dobj|cells blood-derived|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CXCR4 in cord blood-derived CD133 + cells treated with platelet micro-particles .
16222707	0	CD133	13,18	FGF2	93,97	CD133	FGF2	8842	2247	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	Unique human CD133 + leukemia cell line and its modulation towards a mesenchymal phenotype by FGF2 and TGFbeta1 .
12621502	0	CD133	25,30	G-CSF	54,59	CD133	G-CSF	19126(Tax:10090)	12985(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	Large-scale isolation of CD133 + progenitor cells from G-CSF mobilized peripheral blood stem cells .
26350087	0	CD133	70,75	HMGB1	11,16	CD133	HMGB1	8842	3146	Gene	Gene	cells|compound|START_ENTITY Effects|nmod|cells Effects|nmod|END_ENTITY	Effects of HMGB1 on proliferation and apoptosis of human brain_glioma CD133 cells .
25441985	0	CD133	35,40	IL-24	21,26	CD133	IL-24	8842	11009	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Inhibitive effect of IL-24 gene on CD133 -LRB- + -RRB- laryngeal_cancer cells .
17765649	0	CD133	28,33	L-selectin	181,191	CD133	L-selectin	8842	6402	Gene	Gene	+|compound|START_ENTITY Mobilization|nmod|+ stem|nsubj|Mobilization stem|nmod|consumption consumption|nmod|expression expression|nmod|ligand ligand|amod|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
22049617	0	CD133	79,84	MDR1	86,90	CD133	MDR1	8842	5243	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Isolation , characterization and mobilization of prostate_cancer tissue derived CD133 + MDR1 + cells .
25823028	0	CD133	0,5	MDR1	26,30	CD133	MDR1	8842	5243	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	CD133 and DNA-PK regulate MDR1 via the PI3K - or Akt-NF-kB pathway in multidrug-resistant glioblastoma cells in vitro .
15467907	0	CD133	70,75	Oct-4	35,40	CD133	Oct-4	8842	5460	Gene	Gene	cells|nummod|START_ENTITY Expression|nmod|cells Expression|nmod|END_ENTITY	Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood .
26261540	0	CD133	25,30	PROM1	18,23	CD133	PROM1	8842	8842	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of PROM1 -LRB- CD133 -RRB- confers poor prognosis in non-small_cell_lung_cancer .
23161076	0	CD133	31,36	Prominin-1	19,29	CD133	Prominin-1	8842	8842	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Gene Regulation of Prominin-1 -LRB- CD133 -RRB- in Normal and Cancerous Tissues .
23161081	0	CD133	22,27	Prominin-1	29,39	CD133	Prominin-1	19126(Tax:10090)	19126(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	New Insights into the CD133 -LRB- Prominin-1 -RRB- Expression in Mouse and Human Colon_Cancer Cells .
25755719	0	CD133	71,76	TFPI-2	24,30	CD133	TFPI-2	8842	7980	Gene	Gene	expression|nmod|START_ENTITY correlated|nmod|expression correlated|nsubj|expression expression|nmod|END_ENTITY	Decreased expression of TFPI-2 correlated with increased expression of CD133 in cholangiocarcinoma .
20728343	0	CD133	50,55	TLR8	31,35	CD133	TLR8	8842	51311	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Toll-like receptor -LRB- TLR -RRB- 7 and TLR8 expression on CD133 + cells in colorectal_cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression .
16439688	0	CD133	6,11	VEGFR-2	13,20	CD133	VEGFR-2	8842	3791	Gene	Gene	+|compound|START_ENTITY +|dep|progenitor progenitor|compound|END_ENTITY	CD34 - / CD133 + / VEGFR-2 + endothelial progenitor cell subpopulation with potent vasoregenerative capacities .
19995856	0	CD133	25,30	VEGFR-2	16,23	CD133	VEGFR-2	8842	3791	Gene	Gene	+|nsubj|START_ENTITY VEGFR-2|parataxis|+ VEGFR-2|nsubj|Accumulation Accumulation|nmod|+ +|compound|END_ENTITY	Accumulation of VEGFR-2 + / CD133 + cells and decreased number and impaired functionality of CD34 + / VEGFR-2 + cells in patients with SLE .
19995856	0	CD133	25,30	VEGFR-2	95,102	CD133	VEGFR-2	8842	3791	Gene	Gene	+|nsubj|START_ENTITY END_ENTITY|parataxis|+	Accumulation of VEGFR-2 + / CD133 + cells and decreased number and impaired functionality of CD34 + / VEGFR-2 + cells in patients with SLE .
20360595	0	CD133	39,44	VEGFR-2	45,52	CD133	VEGFR-2	8842	3791	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Maternal circulating CD34 + VEGFR-2 + and CD133 + VEGFR-2 + progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia .
22480576	0	CD133	34,39	VEGFR-2	45,52	CD133	VEGFR-2	8842	3791	Gene	Gene	CD45|compound|START_ENTITY CD45|compound|END_ENTITY	Isolation and characterization of CD133 + CD34 + VEGFR-2 + CD45 - fetal endothelial cells from human term placenta .
22558265	0	CD133	43,48	c-kit	50,55	CD133	c-kit	19126(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|dobj|cells cells|amod|END_ENTITY	Overexpression of angiopoietin-1 increases CD133 + / c-kit + cells and reduces myocardial apoptosis in db/db mouse infarcted hearts .
20144269	0	CD133	0,5	galectin-3	101,111	CD133	galectin-3	8842	3958	Gene	Gene	T|nsubj|START_ENTITY T|nmod|END_ENTITY	CD133 -LRB- + -RRB- human pulmonary_adenocarcinoma cells induce apoptosis of CD8 -LRB- + -RRB- T cells by highly expressed galectin-3 .
19738050	0	CD133	58,63	mTOR	0,4	CD133	mTOR	8842	21977(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	mTOR signal and hypoxia-inducible_factor-1_alpha regulate CD133 expression in cancer cells .
23861881	0	CD133	52,57	miR-1915	0,8	CD133	miR-1915	8842	100302129	Gene	Gene	expression|nmod|START_ENTITY regulate|dobj|expression END_ENTITY|dep|regulate	miR-1915 and miR-1225-5p regulate the expression of CD133 , PAX2 and TLR2 in adult renal progenitor cells .
25955157	0	CD133	64,69	miR-1915	12,20	CD133	miR-1915	8842	100302129	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Correction : miR-1915 and miR-1225-5p Regulate the Expression of CD133 , PAX2 and TLR2 in Adult Renal Progenitor Cells .
25955157	0	CD133	64,69	miR-1915	12,20	CD133	miR-1915	8842	100302129	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Correction : miR-1915 and miR-1225-5p Regulate the Expression of CD133 , PAX2 and TLR2 in Adult Renal Progenitor Cells .
24762489	0	CD133	46,51	nucleostemin	14,26	CD133	nucleostemin	8842	26354	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	Comparison of nucleostemin gene expression in CD133 + and CD133 - cell population in colon_cancer cell line HT29 .
23545719	0	CD133	59,64	osteopontin	31,42	CD133	osteopontin	8842	6696	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localisation of osteopontin and prominin-1 -LRB- CD133 -RRB- in patients with endometriosis .
23318676	0	CD133	56,61	prominin-1	45,55	CD133	prominin-1	8842	8842	Gene	Gene	interaction|dep|START_ENTITY interaction|nmod|END_ENTITY	Wnt interaction and extracellular release of prominin-1 / CD133 in human malignant_melanoma cells .
10733518	0	CD134	12,17	CD134L	25,31	CD134	CD134L	22163(Tax:10090)	22164(Tax:10090)	Gene	Gene	Blockade|nmod|START_ENTITY Blockade|dep|ameliorates ameliorates|nummod|END_ENTITY	Blockade of CD134 -LRB- OX40 -RRB- - CD134L interaction ameliorates lethal acute_graft-versus-host_disease in a murine model of allogeneic bone marrow transplantation .
15111929	0	CD134	69,74	CD25	0,4	CD134	CD25	7293	3559	Gene	Gene	T-cell|compound|START_ENTITY subsets|nsubj|T-cell subsets|nsubj|distinguishes distinguishes|compound|END_ENTITY	CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 -LRB- OX40 -RRB- T-cell subsets in acute_graft-versus-host_disease .
16380476	0	CD134	31,36	CD25	16,20	CD134	CD25	7293	3559	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Coexpression of CD25 and OX40 -LRB- CD134 -RRB- receptors delineates autoreactive T-cells in type 1 diabetes .
18723571	0	CD134	40,45	CD25	4,8	CD134	CD25	7293	3559	Gene	Gene	expressing|dobj|START_ENTITY populations|acl|expressing populations|compound|END_ENTITY	CD4 + CD25 + T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener 's _ granulomatosis .
24752698	0	CD134	38,43	CD25	30,34	CD134	CD25	7293	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
24797972	0	CD134	25,30	CD25	69,73	CD134	CD25	7293	3559	Gene	Gene	OX40|appos|START_ENTITY expression|nmod|OX40 molecules|nsubj|expression molecules|nmod|cells cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
24752698	0	CD134	38,43	CD39	47,51	CD134	CD39	7293	953	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
15111929	0	CD134	69,74	CD4	65,68	CD134	CD4	7293	920	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 -LRB- OX40 -RRB- T-cell subsets in acute_graft-versus-host_disease .
15326292	0	CD134	70,75	CD4	48,51	CD134	CD4	7293	920	Gene	Gene	using|dobj|START_ENTITY targets|advcl|using targets|dobj|cells cells|compound|END_ENTITY	Feline_immunodeficiency_virus targets activated CD4 + T cells by using CD134 as a binding receptor .
15591118	0	CD134	20,25	CD4	30,33	CD134	CD4	7293	920	Gene	Gene	OX40|appos|START_ENTITY OX40|nmod|CD25 CD25|compound|END_ENTITY	Triggering of OX40 -LRB- CD134 -RRB- on CD4 -LRB- + -RRB- CD25 + T cells blocks their inhibitory activity : a novel regulatory role for OX40 and its comparison with GITR .
16176850	0	CD134	41,46	CD4	14,17	CD134	CD4	7293	920	Gene	Gene	OX40|appos|START_ENTITY T|nmod|OX40 T|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CD4 T cell memory by OX40 -LRB- CD134 -RRB- .
16367941	0	CD134	20,25	CD4	30,33	CD134	CD4	7293	920	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|T-cells T-cells|compound|END_ENTITY	Expression of OX40 -LRB- CD134 -RRB- on CD4 + T-cells from patients with myasthenia_gravis .
16541471	0	CD134	6,11	CD4	50,53	CD134	CD4	7293	920	Gene	Gene	OX40|appos|START_ENTITY engagement|nsubj|OX40 engagement|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	OX40 -LRB- CD134 -RRB- engagement drives differentiation of CD4 + T cells to effector cells .
16879242	0	CD134	0,5	CD4	20,23	CD134	CD4	7293	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD134 expression on CD4 + T cells is associated with nephritis and disease activity in patients with systemic_lupus_erythematosus .
18723571	0	CD134	40,45	CD4	0,3	CD134	CD4	7293	920	Gene	Gene	expressing|dobj|START_ENTITY populations|acl|expressing populations|compound|END_ENTITY	CD4 + CD25 + T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener 's _ granulomatosis .
22471609	0	CD134	49,54	CD4	58,61	CD134	CD4	7293	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Study on the expression of co-stimulatory marker CD134 on CD4 + T cells in HIV-1-infected individuals .
24752698	0	CD134	38,43	CD4	23,26	CD134	CD4	7293	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
24797972	0	CD134	25,30	CD4	63,66	CD134	CD4	7293	920	Gene	Gene	OX40|appos|START_ENTITY expression|nmod|OX40 molecules|nsubj|expression molecules|nmod|cells cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
26561553	0	CD134	41,46	CD4	16,19	CD134	CD4	7293	920	Gene	Gene	CD137|compound|START_ENTITY CD137|compound|END_ENTITY	Tumor-Unrelated CD4 T Cell Help Augments CD134 Plus CD137 Dual Costimulation Tumor Therapy .
21880986	0	CD134	0,5	Eomesodermin	44,56	CD134	Eomesodermin	22163(Tax:10090)	13813(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation .
11739485	0	CD134	92,97	OX40	86,90	CD134	OX40	22163(Tax:10090)	22163(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Multiple levels of activation of murine CD8 -LRB- + -RRB- intraepithelial lymphocytes defined by OX40 -LRB- CD134 -RRB- expression : effects on cell-mediated cytotoxicity , IFN-gamma , and IL-10 regulation .
12786817	0	CD134	39,44	OX40	46,50	CD134	OX40	7293	7293	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of T-cell activation marker CD134 -LRB- OX40 -RRB- in lymphomatoid_papulosis .
15327522	0	CD134	45,50	OX40	53,57	CD134	OX40	7293	7293	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Kinetic of regulatory CD25high and activated CD134 + -LRB- OX40 -RRB- T lymphocytes during acute and chronic_graft-versus-host_disease after allogeneic bone marrow transplantation .
16367941	0	CD134	20,25	OX40	14,18	CD134	OX40	7293	7293	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of OX40 -LRB- CD134 -RRB- on CD4 + T-cells from patients with myasthenia_gravis .
18374895	0	CD134	6,11	OX40	0,4	CD134	OX40	7293	7293	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	OX40 -LRB- CD134 -RRB- expression in sentinel lymph nodes correlates with prognostic features of primary melanomas .
20795540	0	CD134	18,23	OX40	12,16	CD134	OX40	7293	7293	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of OX40 -LRB- CD134 -RRB- in T-cell memory generation .
10733518	0	CD134L	25,31	CD134	12,17	CD134L	CD134	22164(Tax:10090)	22163(Tax:10090)	Gene	Gene	ameliorates|nummod|START_ENTITY Blockade|dep|ameliorates Blockade|nmod|END_ENTITY	Blockade of CD134 -LRB- OX40 -RRB- - CD134L interaction ameliorates lethal acute_graft-versus-host_disease in a murine model of allogeneic bone marrow transplantation .
9207445	0	CD135	98,103	FLT3	92,96	CD135	FLT3	2322	2322	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 -LRB- CD135 -RRB- receptor tyrosine kinase .
12384425	0	CD137	15,20	4-1BB	8,13	CD137	4-1BB	3604	3604	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of 4-1BB -LRB- CD137 -RRB- in the functional activation of cord blood CD28 -LRB- - -RRB- CD8 -LRB- + -RRB- T cells .
12460192	0	CD137	20,25	4-1BB	13,18	CD137	4-1BB	3604	3604	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of 4-1BB -LRB- CD137 -RRB- expression by DNA damaging agents in human T lymphocytes .
12662292	0	CD137	14,19	4-1BB	21,26	CD137	4-1BB	3604	3604	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD137 -LRB- 4-1BB -RRB- on human follicular dendritic cells .
12706838	0	CD137	49,54	4-1BB	56,61	CD137	4-1BB	3604	3604	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	NF-kappaB and AP-1 regulate activation-dependent CD137 -LRB- 4-1BB -RRB- expression in T cells .
15308117	0	CD137	32,37	4-1BB	25,30	CD137	4-1BB	3604	3604	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Functional expression of 4-1BB -LRB- CD137 -RRB- in the inflammatory tissue in Crohn 's _ disease .
26587331	0	CD137	25,30	4-1BB	32,37	CD137	4-1BB	3604	3604	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Functional expression of CD137 -LRB- 4-1BB -RRB- on T helper follicular cells .
24797972	0	CD137	43,48	CD25	69,73	CD137	CD25	3604	3559	Gene	Gene	OX40|appos|START_ENTITY expression|nmod|OX40 molecules|nsubj|expression molecules|nmod|cells cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
24797972	0	CD137	43,48	CD4	63,66	CD137	CD4	3604	920	Gene	Gene	OX40|appos|START_ENTITY expression|nmod|OX40 molecules|nsubj|expression molecules|nmod|cells cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
18390707	0	CD137	0,5	CD8	23,26	CD137	CD8	3604	925	Gene	Gene	costimulation|nummod|START_ENTITY costimulation|nmod|cells cells|compound|END_ENTITY	CD137 costimulation of CD8 + T cells confers resistance to suppression by virus-induced regulatory T cells .
26600673	0	CD137	0,5	NFATc1	16,22	CD137	NFATc1	21942(Tax:10090)	18018(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-kB p65 Signaling Pathway .
25549946	0	CD137	12,17	TMEM126A	0,8	CD137	TMEM126A	21942(Tax:10090)	66271(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	TMEM126A , a CD137 ligand binding protein , couples with the TLR4 signal transduction pathway in macrophages .
23620528	0	CD137	49,54	Tumor_necrosis_factor	0,21	CD137	Tumor necrosis factor	3604	7124	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Tumor_necrosis_factor receptor 1 associates with CD137 ligand and mediates its reverse signaling .
24715427	0	CD138	10,15	CD19	17,21	CD138	CD19	6382	930	Gene	Gene	case|nmod|START_ENTITY case|parataxis|+ +|compound|END_ENTITY	A case of CD138 - / CD19 + / CD4 + IgD plasma_cell_leukemia .
11598177	0	CD138	12,17	Syndecan-1	0,10	CD138	Syndecan-1	6382	6382	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Syndecan-1 -LRB- CD138 -RRB- immunoreactivity in bone marrow biopsies of multiple myeloma : shed syndecan-1 accumulates in fibrotic regions .
16280658	0	CD138	23,28	syndecan-1	11,21	CD138	syndecan-1	6382	6382	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Utility of syndecan-1 -LRB- CD138 -RRB- expression in the diagnosis of undifferentiated malignant_neoplasms : a tissue microarray study of 1,754 cases .
19342678	0	CD138	53,58	syndecan-1	41,51	CD138	syndecan-1	20969(Tax:10090)	20969(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the heparan sulfate proteoglycan syndecan-1 -LRB- CD138 -RRB- in delayed-type_hypersensitivity .
19860843	0	CD138	20,25	syndecan-1	8,18	CD138	syndecan-1	6382	6382	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of syndecan-1 -LRB- CD138 -RRB- in cell survival of human urothelial_carcinoma .
23137022	0	CD138	51,56	syndecan_1	39,49	CD138	syndecan 1	6382	6382	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Hepatic expression and serum levels of syndecan_1 -LRB- CD138 -RRB- in patients with nonalcoholic_fatty_liver_disease .
22088250	0	CD14	94,98	C-reactive_protein	32,50	CD14	C-reactive protein	12475(Tax:10090)	12944(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY expression|nmod|-RSB- expression|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
15172112	0	CD14	10,14	CCR2	15,19	CD14	CCR2	929	729230	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased CD14 + CCR2 + monocytes in active multiple_sclerosis .
25340088	0	CD14	8,12	CCR2	0,4	CD14	CCR2	929	729230	Gene	Gene	monocytes|amod|START_ENTITY END_ENTITY|nmod|monocytes	CCR2 on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is a biomarker of HIV-associated_neurocognitive_disorders .
19572148	0	CD14	91,95	CD11b	84,89	CD14	CD11b	929	3684	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|nsubj|alterations alterations|nmod|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
15699162	0	CD14	75,79	CD11c	80,85	CD14	CD11c	929	3687	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CpG RNA : identification of novel single-stranded RNA that stimulates human CD14 + CD11c + monocytes .
8659452	0	CD14	23,27	CD13	17,21	CD14	CD13	929	290	Gene	Gene	expression|appos|START_ENTITY expression|dep|END_ENTITY	Myeloid antigen , CD13 , CD14 , and/or CD33 expression is restricted to certain lymphoid_neoplasms .
11349042	0	CD14	0,4	CD14	42,46	CD14	CD14	929	929	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro : lipopolysaccharide activation of epithelial cells revisited .
11349042	0	CD14	42,46	CD14	0,4	CD14	CD14	929	929	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro : lipopolysaccharide activation of epithelial cells revisited .
14996480	0	CD14	29,33	CD14	68,72	CD14	CD14	929	929	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Promoter polymorphism in the CD14 gene and concentration of soluble CD14 in patients with in-stent restenosis after elective coronary stenting .
14996480	0	CD14	68,72	CD14	29,33	CD14	CD14	929	929	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Promoter polymorphism in the CD14 gene and concentration of soluble CD14 in patients with in-stent restenosis after elective coronary stenting .
25168844	0	CD14	23,27	CD14	48,52	CD14	CD14	929	929	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|nmod|Cd16 Cd16|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
25168844	0	CD14	48,52	CD14	23,27	CD14	CD14	929	929	Gene	Gene	Cd16|compound|START_ENTITY Monocytes|nmod|Cd16 Monocytes|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
7531099	0	CD14	129,133	CD14	8,12	CD14	CD14	929	929	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|END_ENTITY	Soluble CD14 is increased in bronchoalveolar lavage of active sarcoidosis and correlates with alveolar_macrophage membrane-bound CD14 .
7531099	0	CD14	8,12	CD14	129,133	CD14	CD14	929	929	Gene	Gene	increased|nsubjpass|START_ENTITY increased|nmod|END_ENTITY	Soluble CD14 is increased in bronchoalveolar lavage of active sarcoidosis and correlates with alveolar_macrophage membrane-bound CD14 .
19572148	0	CD14	91,95	CD15	99,103	CD14	CD15	929	2526	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
10199836	0	CD14	65,69	CD16	73,77	CD14	CD16	929	2214	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|monocyte monocyte|nsubj|END_ENTITY	Distinct scavenger receptor expression and function in the human CD14 -LRB- + -RRB- / CD16 -LRB- + -RRB- monocyte subset .
10353463	0	CD14	18,22	CD16	24,28	CD14	CD16	929	2214	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD14 + + monocytes , CD14 + / CD16 + subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy .
10879684	0	CD14	57,61	CD16	63,67	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The M-DC8-positive leukocytes are a subpopulation of the CD14 + CD16 + monocytes .
10971526	0	CD14	0,4	CD16	5,9	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + monocyte subpopulation in Kawasaki_disease .
11167997	0	CD14	68,72	CD16	73,77	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Haemodialysis monocytopenia : differential sequestration kinetics of CD14 + CD16 + and CD14 + + blood monocyte subsets .
11167997	11	CD14	1352,1356	CD16	1357,1361	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	A decline in CD11c surface density paralleled the sequestration of CD14 + CD16 + monocytes .
11513546	0	CD14	170,174	CD16	152,156	CD14	CD16	929	2214	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|characteristics characteristics|dep|END_ENTITY	Comparative analysis of the morphological , cytochemical , immunophenotypical , and functional characteristics of normal human peripheral blood lineage -LRB- - -RRB- / CD16 -LRB- + -RRB- / HLA-DR -LRB- + -RRB- / CD14 -LRB- - / lo -RRB- cells , CD14 -LRB- + -RRB- monocytes , and CD16 -LRB- - -RRB- dendritic cells .
11513546	0	CD14	188,192	CD16	152,156	CD14	CD16	929	2214	Gene	Gene	monocytes|nsubj|START_ENTITY monocytes|ccomp|CD14 CD14|nsubj|analysis analysis|nmod|characteristics characteristics|dep|END_ENTITY	Comparative analysis of the morphological , cytochemical , immunophenotypical , and functional characteristics of normal human peripheral blood lineage -LRB- - -RRB- / CD16 -LRB- + -RRB- / HLA-DR -LRB- + -RRB- / CD14 -LRB- - / lo -RRB- cells , CD14 -LRB- + -RRB- monocytes , and CD16 -LRB- - -RRB- dendritic cells .
11590624	0	CD14	167,171	CD16	194,198	CD14	CD16	929	2214	Gene	Gene	monocytes|nummod|START_ENTITY monocytes|nmod|subset subset|compound|END_ENTITY	Circulating CD33 + large mononuclear cells contain three distinct populations with phenotype of putative antigen-presenting cells including myeloid dendritic cells and CD14 + monocytes with their CD16 + subset .
11704885	0	CD14	16,20	CD16	22,26	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY invasion|nmod|+ invasion|dep|monocytes monocytes|nummod|END_ENTITY	CNS invasion by CD14 + / CD16 + peripheral blood-derived monocytes in HIV_dementia : perivascular accumulation and reservoir of HIV_infection .
11907116	0	CD14	20,24	CD16	25,29	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The proinflammatory CD14 + CD16 + DR + + monocytes are a major source of TNF .
11958435	0	CD14	4,8	CD16	10,14	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The CD14 + CD16 + monocyte subset in rheumatoid_arthritis and systemic_lupus_erythematosus .
11981819	0	CD14	4,8	CD16	9,13	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The CD14 + CD16 + monocytes in erysipelas are expanded and show reduced cytokine production .
12028567	0	CD14	0,4	CD16	5,9	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + monocytes in the course of sepsis in neonates and small children : monitoring and functional studies .
12384915	0	CD14	0,4	CD16	6,10	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|appos|monocytes monocytes|nummod|END_ENTITY	CD14 + , CD16 + blood monocytes and joint_inflammation in rheumatoid_arthritis .
12832440	0	CD14	55,59	CD16	60,64	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mechanism of glucocorticoid-induced depletion of human CD14 + CD16 + monocytes .
12847232	0	CD14	34,38	CD16	39,43	CD14	CD16	929	2214	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	P-selectin enhances generation of CD14 + CD16 + dendritic-like cells and inhibits macrophage maturation from human peripheral blood monocytes .
12928539	0	CD14	12,16	CD16	18,22	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Circulating CD14 + CD16 + monocytes are expanded in sarcoidosis patients .
14576364	0	CD14	75,79	CD16	80,84	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Autologous stem-cell transplantation restores the functional properties of CD14 + CD16 + monocytes in patients with myeloma and lymphoma .
15269840	0	CD14	0,4	CD16	5,9	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + monocytes in coronary_artery_disease and their relationship to serum TNF-alpha levels .
15308326	0	CD14	22,26	CD16	28,32	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY response|nmod|+ response|parataxis|monocyte monocyte|nsubj|+ +|compound|END_ENTITY	Antitumor response of CD14 + / CD16 + monocyte subpopulation .
15325277	0	CD14	103,107	CD16	108,112	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
15373966	0	CD14	78,82	CD16	72,76	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16 + CD14 + monocytes in patients with septic_shock .
16825330	0	CD14	54,58	CD16	59,63	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	On-line hemodiafiltration reduces the proinflammatory CD14 + CD16 + monocyte-derived dendritic cells : A prospective , crossover study .
16928619	0	CD14	71,75	CD16	76,80	CD14	CD16	929	2214	Gene	Gene	monocyte|compound|START_ENTITY monocyte|compound|END_ENTITY	Biocompatibility study based on differential sequestration kinetics of CD14 + CD16 + blood monocyte subsets with different dialyzers .
17135573	0	CD14	4,8	CD16	10,14	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The CD14 + CD16 + blood monocytes : their role in infection and inflammation .
1715711	0	CD14	7,11	CD16	13,17	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Small -LRB- CD14 + / CD16 + -RRB- monocytes and regular monocytes in human blood .
17619880	0	CD14	27,31	CD16	35,39	CD14	CD16	929	2214	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|compound|END_ENTITY	Selective expansion of the CD14 -LRB- + -RRB- / CD16 -LRB- bright -RRB- subpopulation of circulating monocytes in patients with hemophagocytic_syndrome .
18021284	0	CD14	16,20	CD16	21,25	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Proinflammatory CD14 + CD16 + monocytes are associated with subclinical atherosclerosis in renal transplant patients .
18177452	0	CD14	49,53	CD16	54,58	CD14	CD16	929	2214	Gene	Gene	DR|compound|START_ENTITY DR|compound|END_ENTITY	Adsorptive depletion of elevated proinflammatory CD14 + CD16 + DR + + monocytes in patients with inflammatory_bowel_disease .
18664531	0	CD14	52,56	CD16	57,61	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Exercise training-induced lowering of inflammatory -LRB- CD14 + CD16 + -RRB- monocytes : a role in the anti-inflammatory influence of exercise ?
18952503	0	CD14	24,28	CD16	30,34	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced frequencies of CD14 + + CD16 + , but not CD14 + CD16 + , peripheral blood monocytes in severe asthmatic patients .
18952503	0	CD14	45,49	CD16	50,54	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced frequencies of CD14 + + CD16 + , but not CD14 + CD16 + , peripheral blood monocytes in severe asthmatic patients .
19001052	0	CD14	96,100	CD16	102,106	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Different functions of monocyte subsets in familial_hypercholesterolemia : potential function of CD14 + CD16 + monocytes in detoxification of oxidized LDL .
19950429	0	CD14	0,4	CD16	39,43	CD14	CD16	929	2214	Gene	Gene	CD16|compound|START_ENTITY CD16|nmod|END_ENTITY	CD14 -LRB- high -RRB- CD16 -LRB- + -RRB- rather than CD14 -LRB- low -RRB- CD16 -LRB- + -RRB- monocytes correlate with disease progression in chronic HIV-infected patients .
19950429	0	CD14	30,34	CD16	10,14	CD14	CD16	929	2214	Gene	Gene	CD16|compound|START_ENTITY END_ENTITY|nmod|CD16	CD14 -LRB- high -RRB- CD16 -LRB- + -RRB- rather than CD14 -LRB- low -RRB- CD16 -LRB- + -RRB- monocytes correlate with disease progression in chronic HIV-infected patients .
20231419	0	CD14	45,49	CD16	51,55	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The levels of CD16/Fc _ gamma_receptor_IIIA on CD14 + CD16 + monocytes are higher in children with severe Plasmodium_falciparum anemia than in children with cerebral or uncomplicated malaria .
20580035	0	CD14	145,149	CD16	150,154	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Adding exercise to rosuvastatin treatment : influence on C-reactive_protein , monocyte toll-like_receptor_4 expression , and inflammatory monocyte -LRB- CD14 + CD16 + -RRB- population .
20586272	0	CD14	17,21	CD16	22,26	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	-LSB- CD14 + + CD16 - and CD14 + CD16 + human monocytes adhesion to endothelial cells -RSB- .
20662093	0	CD14	76,80	CD16	81,85	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Standardized single-platform assay for human monocyte subpopulations : Lower CD14 + CD16 + + monocytes in females .
20943670	0	CD14	0,4	CD16	6,10	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + + CD16 + monocytes and cardiovascular outcome in patients with chronic_kidney_disease .
21191073	0	CD14	10,14	CD16	15,19	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Senescent CD14 + CD16 + monocytes exhibit proinflammatory and proatherosclerotic activity .
21303362	0	CD14	49,53	CD16	55,59	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Elevated blood levels of inflammatory monocytes -LRB- CD14 + CD16 + -RRB- in patients with complex_regional_pain_syndrome .
21368871	0	CD14	113,117	CD16	15,19	CD14	CD16	929	2214	Gene	Gene	CD16|compound|START_ENTITY apoptosis|nmod|CD16 susceptible|nmod|apoptosis subset|amod|susceptible monocyte|ccomp|subset monocyte|nsubj|END_ENTITY	The CD14 -LRB- + / low -RRB- CD16 -LRB- + -RRB- monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14 -LRB- + -RRB- CD16 -LRB- - -RRB- subset .
21368871	0	CD14	4,8	CD16	120,124	CD14	CD16	929	2214	Gene	Gene	CD16|compound|START_ENTITY monocyte|nsubj|CD16 monocyte|ccomp|subset subset|amod|susceptible susceptible|nmod|apoptosis apoptosis|nmod|END_ENTITY	The CD14 -LRB- + / low -RRB- CD16 -LRB- + -RRB- monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14 -LRB- + -RRB- CD16 -LRB- - -RRB- subset .
21531464	0	CD14	45,49	CD16	38,42	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The response to TLR ligation of human CD16 CD14 monocytes is weakly modulated as a consequence of persistent infection with the hepatitis_C_virus .
21544980	0	CD14	18,22	CD16	23,27	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Subpopulation of CD14 + CD16 + monocytes in the children with acute_lymphoblastic_leukemia treated with filgrastim -RSB- .
21625090	0	CD14	0,4	CD16	5,9	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	CD14 + CD16 + monocytes from chronic kidney_disease patients exhibit increased adhesion ability to endothelial cells .
21695694	0	CD14	67,71	CD16	75,79	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The classical CD14 CD16 monocytes , but not the patrolling CD14 CD16 monocytes , promote Th17 responses to Candida_albicans .
21799175	0	CD14	17,21	CD16	22,26	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14dimCD16 + and CD14 + CD16 + monocytes in obesity and during weight_loss : relationships with fat mass and subclinical atherosclerosis .
21803849	0	CD14	23,27	CD16	29,33	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	SuperSAGE evidence for CD14 + + CD16 + monocytes as a third monocyte subset .
21838603	0	CD14	106,110	CD16	65,69	CD14	CD16	929	2214	Gene	Gene	CD16|compound|START_ENTITY CD64|nmod|CD16 CD64|nsubj|differentiation differentiation|nmod|END_ENTITY	Mesenchymal stromal cells impair the differentiation of CD14 -LRB- + + -RRB- CD16 -LRB- - -RRB- CD64 -LRB- + -RRB- classical monocytes into CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD64 -LRB- + + -RRB- activate monocytes .
21838603	0	CD14	56,60	CD16	115,119	CD14	CD16	929	2214	Gene	Gene	CD16|compound|START_ENTITY differentiation|nmod|CD16 CD64|nsubj|differentiation CD64|nmod|END_ENTITY	Mesenchymal stromal cells impair the differentiation of CD14 -LRB- + + -RRB- CD16 -LRB- - -RRB- CD64 -LRB- + -RRB- classical monocytes into CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD64 -LRB- + + -RRB- activate monocytes .
21847775	0	CD14	16,20	CD16	21,25	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Proinflammatory CD14 + CD16 + monocytes are associated with microinflammation in patients with type_2_diabetes_mellitus and diabetic_nephropathy_uremia .
21936856	0	CD14	24,28	CD16	30,34	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Possible involvement of CD14 + CD16 + monocyte lineage cells in the epidermal_damage of Stevens-Johnson_syndrome and toxic_epidermal_necrolysis .
22006178	0	CD14	4,8	CD16	17,21	CD14	CD16	929	2214	Gene	Gene	subset|compound|START_ENTITY subset|amod|END_ENTITY	The CD14 -LRB- bright -RRB- CD16 + monocyte subset is expanded in rheumatoid_arthritis and promotes expansion of the Th17 cell population .
22247233	0	CD14	68,72	CD16	73,77	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Losartan prevents the development of the pro-inflammatory monocytes CD14 + CD16 + in haemodialysis patients .
22484242	0	CD14	13,17	CD16	18,22	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of CD14 + CD16 + monocytes producing TNF-a in complication-free_diabetes_type_1 juvenile onset patients .
22961048	0	CD14	62,66	CD16	67,71	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Selective expansion of pro-inflammatory chemokine CCL2-loaded CD14 + CD16 + monocytes subset in HIV-infected therapy na ve individuals .
23046368	0	CD14	24,28	CD16	31,35	CD14	CD16	929	2214	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Adsorptive depletion of CD14 CD16 proinflammatory monocyte phenotype in patients with generalized pustular_psoriasis : clinical efficacy and effects on cytokines .
23240665	0	CD14	0,4	CD16	6,10	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + + CD16 + monocytes in patients with acute ischaemic heart_failure .
23595503	0	CD14	23,27	CD16	29,33	CD14	CD16	929	2214	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Reduced frequency of a CD14 + CD16 + monocyte subset with high Toll-like_receptor_4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns .
24001047	0	CD14	45,49	CD16	50,54	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Comparison of the proportion of non-classic -LRB- CD14 + CD16 + -RRB- monocytes/macrophages in peripheral blood and gingiva of healthy individuals and patients with chronic_periodontitis .
24182800	0	CD14	20,24	CD16	25,29	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation between CD14 + CD16 + + monocytes in peripheral blood and hypertriglyceridemia after allograft renal transplantation .
24432835	0	CD14	120,124	CD16	125,129	CD14	CD16	697482(Tax:9544)	720006(Tax:9544)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus_macaques decreases the frequency of circulating CD14 + CD16 + + monocytes but does not alter the tissue virus reservoir .
24499053	0	CD14	0,4	CD16	5,9	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + and CD14 + CD163 + monocyte subpopulations in kidney allograft transplantation .
24650765	6	CD14	1070,1074	CD16	1079,1083	CD14	CD16	929	2214	Gene	Gene	population|amod|START_ENTITY population|amod|END_ENTITY	In both normal and SLE patients , the CD14 CD16 subpopulation of monocytes expressed the highest levels of Mer , with somewhat lower levels on the CD14 -LRB- int -RRB- CD16 population .
24661393	0	CD14	38,42	CD16	8,12	CD14	CD16	929	2214	Gene	Gene	CD51/61|compound|START_ENTITY marker|advcl|CD51/61 monocytes|ccomp|marker monocytes|nsubj|END_ENTITY	CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes rather than CD14 -LRB- + -RRB- CD51/61 -LRB- + -RRB- monocytes are a potential cytological marker of circulating osteoclast precursors in multiple_myeloma .
24832193	0	CD14	74,78	CD16	79,83	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Resistance exercise training-induced decrease in circulating inflammatory CD14 + CD16 + monocyte percentage without weight_loss in older adults .
24995492	0	CD14	50,54	CD16	56,60	CD14	CD16	929	2214	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Trophoblast induces monocyte differentiation into CD14 + / CD16 + macrophages .
25060791	0	CD14	77,81	CD16	83,87	CD14	CD16	929	2214	Gene	Gene	counts|compound|START_ENTITY counts|compound|END_ENTITY	Lower Apo_A-I_and_lower_HDL-C levels are associated with higher intermediate CD14 + + CD16 + monocyte counts that predict cardiovascular_events in chronic_kidney_disease .
25134759	0	CD14	91,95	CD16	98,102	CD14	CD16	929	2214	Gene	Gene	monocytes|nummod|START_ENTITY monocytes|compound|END_ENTITY	Bezafibrate , a peroxisome proliferator-activated receptor a agonist , decreases circulating CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes in patients with type 2 diabetes .
25168844	0	CD14	23,27	CD16	28,32	CD14	CD16	929	2214	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
25168844	0	CD14	48,52	CD16	28,32	CD14	CD16	929	2214	Gene	Gene	Cd16|compound|START_ENTITY Monocytes|nmod|Cd16 Monocytes|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
25172544	0	CD14	63,67	CD16	69,73	CD14	CD16	929	2214	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Human endotoxin tolerance is associated with enrichment of the CD14 + CD16 + monocyte subset .
25233271	0	CD14	4,8	CD16	9,13	CD14	CD16	929	2214	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	The CD14 + CD16 + inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium_vivax malaria .
25340088	0	CD14	8,12	CD16	15,19	CD14	CD16	929	2214	Gene	Gene	monocytes|amod|START_ENTITY monocytes|amod|END_ENTITY	CCR2 on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is a biomarker of HIV-associated_neurocognitive_disorders .
25420915	0	CD14	80,84	CD16	85,89	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14 + CD16 + monocytes in HIV-infected individuals .
25850575	0	CD14	0,4	CD16	9,13	CD14	CD16	929	2214	Gene	Gene	Monocytes|amod|START_ENTITY Monocytes|amod|END_ENTITY	CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- HLA-DR -LRB- + -RRB- Monocytes in Peripheral Blood are Quantitatively Correlated with the Severity of Pre-eclampsia .
25911752	0	CD14	0,4	CD16	6,10	CD14	CD16	929	2214	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	CD14 + + CD16 + Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses .
26550139	0	CD14	13,17	CD16	20,24	CD14	CD16	929	2214	Gene	Gene	monocytes|amod|START_ENTITY monocytes|amod|END_ENTITY	Expansion of CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is related to acute_leukemia .
26578679	0	CD14	99,103	CD16	105,109	CD14	CD16	929	2214	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14 + CD16 + CD64high CD32low Inflammatory Monocytes from Malaria Patients .
26658828	0	CD14	62,66	CD16	68,72	CD14	CD16	929	2214	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	Increased Protease-Activated_Receptor-2 -LRB- PAR-2 -RRB- Expression on CD14 + + CD16 + Peripheral Blood Monocytes of Patients with Severe Asthma .
26747736	0	CD14	24,28	CD16	30,34	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY circulating|dobj|+ Analysis|acl|circulating Analysis|parataxis|+ +|nsubj|END_ENTITY	Analysis of circulating CD14 + / CD16 + monocyte-derived macrophages -LRB- MDMs -RRB- in the peripheral blood of patients with oral_squamous_cell_carcinoma .
26826137	0	CD14	25,29	CD16	31,35	CD14	CD16	929	2214	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Circulating intermediate CD14 + + CD16 + monocytes are increased in patients with atrial_fibrillation and reflect the functional remodelling of the left atrium .
7543538	0	CD14	21,25	CD16	42,46	CD14	CD16	929	2214	Gene	Gene	receptors|appos|START_ENTITY found|nsubjpass|receptors found|nmod|END_ENTITY	Endotoxin receptors -LRB- CD14 -RRB- are found with CD16 -LRB- Fc_gamma_RIII -RRB- in an intracellular compartment of neutrophils that contains alkaline phosphatase .
7690321	0	CD14	20,24	CD16	26,30	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY subset|nmod|+ subset|parataxis|exhibits exhibits|nsubj|monocytes monocytes|compound|END_ENTITY	The novel subset of CD14 + / CD16 + blood monocytes exhibits features of tissue macrophages .
7693040	0	CD14	20,24	CD16	26,30	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY subset|nmod|+ subset|parataxis|expanded expanded|nsubjpass|monocytes monocytes|compound|END_ENTITY	The novel subset of CD14 + / CD16 + blood monocytes is expanded in sepsis patients .
9249916	0	CD14	46,50	CD16	51,55	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cytokine production precedes the expansion of CD14 + CD16 + monocytes in human sepsis : a case report of a patient with self-induced septicemia .
9596748	0	CD14	9,13	CD16	15,19	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expanded CD14 + CD16 + monocyte subpopulation in patients with acute and chronic_infections undergoing hemodialysis .
9649222	0	CD14	23,27	CD16	29,33	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Selective depletion of CD14 + CD16 + monocytes by glucocorticoid therapy .
9675608	0	CD14	13,17	CD16	18,22	CD14	CD16	929	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of CD14 + CD16 + monocytes in critically ill cardiac surgery patients .
21135497	0	CD14	0,4	CD163	6,11	CD14	CD163	929	9332	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	CD14 + CD163 + IL-10 + monocytes/macrophages : Pro-angiogenic and non pro-inflammatory isolation , enrichment and long-term secretion profile .
21691249	0	CD14	72,76	CD163	78,83	CD14	CD163	929	9332	Gene	Gene	+|compound|START_ENTITY role|nmod|+ closure|dep|role closure|dep|+ +|compound|END_ENTITY	Anatomic closure of the premature patent ductus arteriosus : The role of CD14 + / CD163 + mononuclear cells and VEGF in neointimal mound formation .
22902818	0	CD14	15,19	CD163	32,37	CD14	CD163	929	9332	Gene	Gene	CD16|compound|START_ENTITY CD16|appos|END_ENTITY	Pro-angiogenic CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD163 -LRB- + -RRB- monocytes accelerate the in vitro endothelialization of soft hydrophobic poly _ -LRB- n-butyl_acrylate -RRB- networks .
24499053	0	CD14	15,19	CD163	20,25	CD14	CD163	929	9332	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + and CD14 + CD163 + monocyte subpopulations in kidney allograft transplantation .
25544986	0	CD14	24,28	CD163	109,114	CD14	CD163	929	9332	Gene	Gene	START_ENTITY|acl|+ +|dobj|Normalisation Normalisation|nmod|END_ENTITY	Elevated Plasma Soluble CD14 and Skewed CD16 + Monocyte Distribution Persist despite Normalisation of Soluble CD163 and CXCL10 by Effective HIV Therapy : A Changing Paradigm for Routine HIV Laboratory Monitoring ?
25944005	0	CD14	6,10	CD163	0,5	CD14	CD163	929	9332	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD163 + CD14 + macrophages , a potential immune biomarker for malignant_pleural_effusion .
25944005	0	CD14	6,10	CD163	0,5	CD14	CD163	929	9332	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD163 + CD14 + macrophages , a potential immune biomarker for malignant_pleural_effusion .
24419414	0	CD14	12,16	CD204	17,22	CD14	CD204	929	4481	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD14 + CD204 + cells predict postoperative recurrence in non-small-cell lung_cancer patients .
24599281	0	CD14	106,110	CD206	111,116	CD14	CD206	929	4360	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Moraxella_catarrhalis adhesin UspA1-derived recombinant fragment rD-7 induces monocyte differentiation to CD14 + CD206 + phenotype .
1379402	0	CD14	20,24	CD33	6,10	CD14	CD33	929	945	Gene	Gene	CD13|parataxis|START_ENTITY CD4|dep|CD13 CD4|nummod|END_ENTITY	CD4 + , CD33 - , CD13 - , CD14 - acute_monoblastic_leukaemia .
19572148	0	CD14	91,95	CD33	105,109	CD14	CD33	929	945	Gene	Gene	+|compound|START_ENTITY +|parataxis|lymphocytes lymphocytes|nsubj|cells cells|nummod|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
23904440	0	CD14	0,4	CD33	5,9	CD14	CD33	929	945	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD33 + myeloid cell-CCL11-eosinophil signature in ulcerative_colitis .
24495013	0	CD14	42,46	CD33	34,38	CD14	CD33	929	945	Gene	Gene	HLA-DR|compound|START_ENTITY myeloid-derived|nsubj|HLA-DR myeloid-derived|nsubj|frequencies frequencies|nmod|END_ENTITY	Increased frequencies of CD11b -LRB- + -RRB- CD33 -LRB- + -RRB- CD14 -LRB- + -RRB- HLA-DR -LRB- low -RRB- myeloid-derived suppressor cells are an early event in melanoma patients .
8659452	0	CD14	23,27	CD33	36,40	CD14	CD33	929	945	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Myeloid antigen , CD13 , CD14 , and/or CD33 expression is restricted to certain lymphoid_neoplasms .
10090933	0	CD14	146,150	CD34	27,31	CD14	CD34	929	947	Gene	Gene	amplification|nmod|START_ENTITY induces|dobj|amplification induces|nsubj|culture culture|nmod|progenitors progenitors|compound|END_ENTITY	Long-term culture of human CD34 -LRB- + -RRB- progenitors with FLT3-ligand , thrombopoietin , and stem cell factor induces extensive amplification of a CD34 -LRB- - -RRB- CD14 -LRB- - -RRB- and a CD34 -LRB- - -RRB- CD14 -LRB- + -RRB- dendritic cell precursor .
10528188	0	CD14	19,23	CD34	0,4	CD14	CD34	929	947	Gene	Gene	cells|compound|START_ENTITY develop|nsubj|cells cell-derived|ccomp|develop cell-derived|nsubj|+ +|compound|END_ENTITY	CD34 + cell-derived CD14 + precursor cells develop into Langerhans cells in a TGF-beta_1-dependent manner .
10623814	0	CD14	67,71	CD34	72,76	CD14	CD34	929	947	Gene	Gene	precursors|compound|START_ENTITY precursors|compound|END_ENTITY	uPA/uPAR system is active in immature dendritic cells derived from CD14 + CD34 + precursors and is down-regulated upon maturation .
12393747	0	CD14	89,93	CD34	84,88	CD14	CD34	929	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Transendothelial migration leads to protection from starvation-induced apoptosis in CD34 + CD14 + circulating precursors : evidence for PECAM-1 involvement through Akt/PKB activation .
15947790	0	CD14	94,98	CD34	80,84	CD14	CD34	929	947	Gene	Gene	Correlation|dep|START_ENTITY Correlation|nmod|plasticity plasticity|nmod|+ +|compound|END_ENTITY	Correlation between differentiation plasticity and mRNA expression profiling of CD34 + - derived CD14 - and CD14 + human normal myeloid precursors .
16959899	0	CD14	90,94	CD34	2,6	CD14	CD34	929	947	Gene	Gene	CD11b|compound|START_ENTITY evidence|nmod|CD11b model|dep|evidence Langerhans|nsubj|model Langerhans|nsubj|END_ENTITY	A CD34 -LRB- + -RRB- human cell line model of myeloid dendritic cell differentiation : evidence for a CD14 -LRB- + -RRB- CD11b -LRB- + -RRB- Langerhans cell precursor .
17595380	0	CD14	33,37	CD34	102,106	CD14	CD34	929	947	Gene	Gene	CD16|compound|START_ENTITY Expansion|nmod|CD16 +|nsubj|Expansion +|nmod|progenitors progenitors|compound|END_ENTITY	Expansion and differentiation of CD14 + CD16 -LRB- - -RRB- and CD14 + + CD16 + human monocyte subsets from cord blood CD34 + hematopoietic progenitors .
18752636	0	CD14	56,60	CD34	0,4	CD14	CD34	929	947	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ differentiation|nmod|cells augment|dobj|differentiation augment|nsubj|cells cells|compound|END_ENTITY	CD34 + cells augment endothelial cell differentiation of CD14 + endothelial progenitor cells in vitro .
21808991	0	CD14	0,4	CD34	6,10	CD14	CD34	929	947	Gene	Gene	START_ENTITY|parataxis|population population|nsubj|+ +|compound|END_ENTITY	CD14 - / CD34 + is the founding population of umbilical cord blood-derived endothelial progenitor cells and angiogenin1 is an important factor promoting the colony formation .
7691941	1	CD14	153,157	CD34	141,145	CD14	CD34	929	947	Gene	Gene	Ly|parataxis|START_ENTITY Ly|dep|progenitor progenitor|nmod|+ +|appos|+ +|compound|END_ENTITY	Characterization of the circulating mast cell progenitor as a c-kit + , CD34 + , Ly - , CD14 - , CD17 - , colony-forming cell .
9051248	0	CD14	46,50	CD34	96,100	CD14	CD34	929	947	Gene	Gene	cells|compound|START_ENTITY system|nmod|cells system|nmod|cells cells|compound|END_ENTITY	A rapid nylon-fiber syringe system to deplete CD14 + cells for positive selection of human blood CD34 + cells .
9715264	0	CD14	121,125	CD34	97,101	CD14	CD34	929	947	Gene	Gene	precursors|amod|START_ENTITY precursors|amod|END_ENTITY	IL-4 and CD40 ligation affect differently the differentiation , maturation , and function of human CD34 + cell-derived CD1a + CD14 - and CD1a-CD14 + dendritic cell precursors in vitro .
21838603	0	CD14	106,110	CD64	73,77	CD14	CD64	929	2209	Gene	Gene	CD16|compound|START_ENTITY END_ENTITY|nmod|CD16	Mesenchymal stromal cells impair the differentiation of CD14 -LRB- + + -RRB- CD16 -LRB- - -RRB- CD64 -LRB- + -RRB- classical monocytes into CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD64 -LRB- + + -RRB- activate monocytes .
25168844	0	CD14	23,27	Cd16	54,58	CD14	Cd16	929	2214	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|nmod|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
23686762	0	CD14	42,46	Corticotropin_releasing_hormone	0,31	CD14	Corticotropin releasing hormone	929	1392	Gene	Gene	cells|amod|START_ENTITY activates|dobj|cells activates|nsubj|END_ENTITY	Corticotropin_releasing_hormone activates CD14 -LRB- + -RRB- cells to induce endothelial_barrier_dysfunction .
8555479	0	CD14	0,4	G-CSF	54,59	CD14	G-CSF	929	1440	Gene	Gene	cells|nummod|START_ENTITY cells|appos|END_ENTITY	CD14 + cells in granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow_stroma .
8911145	0	CD14	64,68	Granulocyte-macrophage_colony-stimulating_factor	0,48	CD14	Granulocyte-macrophage colony-stimulating factor	929	1437	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor down-regulates CD14 expression on monocytes .
15331624	0	CD14	75,79	HMGB1	54,59	CD14	HMGB1	12475(Tax:10090)	15289(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|dobj|END_ENTITY	Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14 - and TNF-dependent mechanisms .
22809173	0	CD14	79,83	HMGB1	0,5	CD14	HMGB1	929	3146	Gene	Gene	+|compound|START_ENTITY monocytes|nummod|+ differentiation|nmod|monocytes promotes|dobj|differentiation promotes|nsubj|END_ENTITY	HMGB1 promotes the differentiation of Th17 via up-regulating TLR2 and IL-23 of CD14 + monocytes from patients with rheumatoid_arthritis .
23508573	0	CD14	100,104	HMGB1	40,45	CD14	HMGB1	929	3146	Gene	Gene	Signaling|nsubj|START_ENTITY Signaling|nmod|high_mobility_group_box_1 high_mobility_group_box_1|appos|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
25660311	0	CD14	128,132	HMGB1	0,5	CD14	HMGB1	12475(Tax:10090)	15289(Tax:10090)	Gene	Gene	Binds|nmod|START_ENTITY Binds|nsubj|END_ENTITY	HMGB1 Binds to Lipoteichoic_Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic_Acid to CD14 and TLR2 .
10601848	0	CD14	38,42	IFN-beta	63,71	CD14	IFN-beta	12475(Tax:10090)	15977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Important role of membrane-associated CD14 in the induction of IFN-beta and subsequent nitric_oxide production by murine macrophages in response to bacterial lipopolysaccharide .
7545713	0	CD14	21,25	IL-13	0,5	CD14	IL-13	929	3596	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	IL-13 down-regulates CD14 expression and TNF-alpha secretion in normal human monocytes .
7522293	0	CD14	44,48	IL-4	0,4	CD14	IL-4	929	3565	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits the LPS-induced expression of CD14 and monocyte-specific esterase mRNA in MONO-MAC-6 cells .
15325277	0	CD14	103,107	Interleukin-10	0,14	CD14	Interleukin-10	929	3586	Gene	Gene	+|compound|START_ENTITY population|nmod|+ development|nmod|population contributes|nmod|development contributes|nsubj|END_ENTITY	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
19796181	0	CD14	30,34	Interleukin-10	0,14	CD14	Interleukin-10	929	3586	Gene	Gene	cells|nummod|START_ENTITY secretion|nmod|cells secretion|amod|END_ENTITY	Interleukin-10 secretion from CD14 + peripheral blood mononuclear cells is downregulated in patients with acne_vulgaris .
1701391	0	CD14	47,51	Interleukin_4	0,13	CD14	Interleukin 4	929	3565	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Interleukin_4 down-regulates the expression of CD14 in normal human monocytes .
1725131	0	CD14	47,51	Interleukin_4	0,13	CD14	Interleukin 4	929	3565	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Interleukin_4 down-regulates the expression of CD14 and the production of interleukin_6 in acute_myeloid_leukemia cells .
26927558	0	CD14	51,55	LAG-3	32,37	CD14	LAG-3	929	3902	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	-LSB- Decreased expression levels of LAG-3 and CD49b on CD14 -LRB- + -RRB- ; cells in peripheral blood of patients with recurrent spontaneous_abortion -RSB- .
19115038	0	CD14	34,38	LBP	57,60	CD14	LBP	60350(Tax:10116)	29469(Tax:10116)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Screening of mimetic peptides for CD14 binding site with LBP and antiendotoxin activity of mimetic peptide in vivo and in vitro .
21390520	0	CD14	32,36	LY96	0,4	CD14	LY96	929	23643	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	LY96 , UPKIB mutations and TLR4 , CD14 , MBL polymorphisms in children with urinary_tract_infection .
9396923	0	CD14	47,51	Lipopolysaccharide_binding_protein	0,34	CD14	Lipopolysaccharide binding protein	929	3929	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Lipopolysaccharide_binding_protein and soluble CD14 receptor protein in amniotic fluid and cord blood in patients at term .
20100200	0	CD14	33,37	MCP-1	9,14	CD14	MCP-1	929	6347	Gene	Gene	cells|compound|START_ENTITY release|nmod|cells release|compound|END_ENTITY	Enhanced MCP-1 release by keloid CD14 + cells augments fibroblast proliferation : role of MCP-1 and Akt pathway in keloids .
24339336	0	CD14	14,18	MD-2	29,33	CD14	MD-2	12475(Tax:10090)	17087(Tax:10090)	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Modulation of CD14 and TLR4 MD-2 activities by a synthetic lipid A mimetic .
7583357	0	CD14	68,72	Mac-2-binding_protein	29,50	CD14	Mac-2-binding protein	929	3959	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	LPS-dependent interaction of Mac-2-binding_protein with immobilized CD14 .
25361854	0	CD14	37,41	PD-L1	31,36	CD14	PD-L1	929	29126	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	High and interrelated rates of PD-L1 + CD14 + antigen-presenting cells and regulatory T cells mark the microenvironment of metastatic lymph nodes from patients with cervical_cancer .
25973094	0	CD14	15,19	TGF-b1	123,129	CD14	TGF-b1	929	7040	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CD14 and TLR4 with LPS-stimulated human normal skin fibroblasts in immunophenotype changes and secretion of TGF-b1 and IFN-y .
18569070	0	CD14	110,114	THP-1	75,80	CD14	THP-1	929	2736	Gene	Gene	removal|nmod|START_ENTITY monocytes|nmod|removal monocytes|compound|END_ENTITY	Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14 .
19890360	0	CD14	79,83	THP-1	169,174	CD14	THP-1	929	2736	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nmod|line line|amod|beta-arrestin-2 beta-arrestin-2|nmod|cell cell|compound|END_ENTITY	Fenoterol , a beta -LRB- 2 -RRB- - adrenoceptor agonist , inhibits LPS-induced membrane-bound CD14 , TLR4/CD14 complex , and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line .
7681085	0	CD14	45,49	THP-1	53,58	CD14	THP-1	929	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Cross-linking of lipopolysaccharide -LRB- LPS -RRB- to CD14 on THP-1 cells mediated by LPS-binding_protein .
9790819	0	CD14	120,124	THP-1	88,93	CD14	THP-1	929	2736	Gene	Gene	ligation|compound|START_ENTITY role|nmod|ligation Antagonism|dep|role Antagonism|nmod|activation activation|nmod|cells cells|compound|END_ENTITY	Antagonism by IL-4 and IL-10 of endotoxin-induced tissue factor activation in monocytic THP-1 cells : activating role of CD14 ligation .
16670636	0	CD14	12,16	TLR2	0,4	CD14	TLR2	929	7097	Gene	Gene	CD11B|appos|START_ENTITY CD11B|compound|END_ENTITY	TLR2 , TLR4 , CD14 , CD11B , and CD11C expressions on monocytes surface and cytokine production in patients with sepsis , severe sepsis , and septic_shock .
17565650	0	CD14	25,29	TLR2	56,60	CD14	TLR2	929	7097	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Genetic polymorphisms of CD14 and Toll-like_receptor-2 -LRB- TLR2 -RRB- in patients with ulcerative_colitis .
18559343	0	CD14	113,117	TLR2	88,92	CD14	TLR2	929	7097	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	Oxidized phospholipid inhibition of toll-like receptor -LRB- TLR -RRB- signaling is restricted to TLR2 and TLR4 : roles for CD14 , LPS-binding_protein , and MD2 as targets for specificity of inhibition .
19080469	5	CD14	1776,1780	TLR2	1759,1763	CD14	TLR2	929	7097	Gene	Gene	monocytes|nummod|START_ENTITY rmfi|nmod|monocytes rmfi|nmod|END_ENTITY	The rmfi of TLR2 and TLR4 on CD14 + monocytes of the healthy smokers was lower than that of the nonsmokers -LRB- P < 0.05 -RRB- , while the rpcp of TLR2 and TLR4 on CD14 + monocytes of the healthy smokers was similar to that of the nonsmoker -LRB- P < 0.05 -RRB- .
20113368	0	CD14	119,123	TLR2	26,30	CD14	TLR2	12475(Tax:10090)	24088(Tax:10090)	Gene	Gene	triggered|nmod|START_ENTITY pathway|acl|triggered internalized|nmod|pathway ligand|ccomp|internalized ligand|nsubj|Toll-like_receptor_2 Toll-like_receptor_2|appos|END_ENTITY	The Toll-like_receptor_2 -LRB- TLR2 -RRB- ligand FSL-1 is internalized via the clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR2 .
22809173	0	CD14	79,83	TLR2	61,65	CD14	TLR2	929	7097	Gene	Gene	+|compound|START_ENTITY monocytes|nummod|+ differentiation|nmod|monocytes differentiation|nmod|Th17 Th17|nmod|END_ENTITY	HMGB1 promotes the differentiation of Th17 via up-regulating TLR2 and IL-23 of CD14 + monocytes from patients with rheumatoid_arthritis .
25942429	0	CD14	28,32	TLR2	0,4	CD14	TLR2	929	7097	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	TLR2 and TLR4 expression on CD14 -LRB- + + -RRB- and CD14 -LRB- + -RRB- monocyte subtypes in adult-onset autoimmune_diabetes .
11274165	1	CD14	113,117	TLR4	121,125	CD14	TLR4	929	7099	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	transfer from CD14 to TLR4 and MD-2 .
11350737	0	CD14	64,68	TNF-alpha	13,22	CD14	TNF-alpha	12475(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of TNF-alpha and MnSOD by endotoxin : role of membrane CD14 and Toll-like_receptor-4 .
24622882	0	CD14	54,58	Toll-like_receptor-9	8,28	CD14	Toll-like receptor-9	929	54106	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduced Toll-like_receptor-9 expression on peripheral CD14 + monocytes of chronic hepatitis_B patients and its restoration by effective therapy .
15860745	0	CD14	83,87	Toll-like_receptor_4	17,37	CD14	Toll-like receptor 4	929	7099	Gene	Gene	monocytes|compound|START_ENTITY signaling|nmod|monocytes expression|acl|signaling expression|compound|END_ENTITY	Statins decrease Toll-like_receptor_4 expression and downstream signaling in human CD14 + monocytes .
17577821	0	CD14	43,47	Toll-like_receptor_4	19,39	CD14	Toll-like receptor 4	929	7099	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	High expression of Toll-like_receptor_4 on CD14 + monocytes in acute infectious_diseases .
22078883	0	CD14	0,4	Toll-like_receptor_4	45,65	CD14	Toll-like receptor 4	929	7099	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|endocytosis endocytosis|nmod|END_ENTITY	CD14 controls the LPS-induced endocytosis of Toll-like_receptor_4 .
22088250	0	CD14	94,98	Toll-like_receptor_4	59,79	CD14	Toll-like receptor 4	12475(Tax:10090)	21898(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY expression|nmod|-RSB- expression|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
23595503	0	CD14	23,27	Toll-like_receptor_4	61,81	CD14	Toll-like receptor 4	929	7099	Gene	Gene	subset|compound|START_ENTITY subset|nmod|expression expression|compound|END_ENTITY	Reduced frequency of a CD14 + CD16 + monocyte subset with high Toll-like_receptor_4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns .
24518547	0	CD14	69,73	Toll-like_receptor_4	23,43	CD14	Toll-like receptor 4	929	7099	Gene	Gene	monocytes|compound|START_ENTITY expression|nmod|monocytes expression|compound|END_ENTITY	Hydrocortisone reduces Toll-like_receptor_4 expression on peripheral CD14 + monocytes in patients undergoing percutaneous coronary intervention .
26550333	0	CD14	65,69	Toll-like_receptor_4	24,44	CD14	Toll-like receptor 4	929	7099	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Different regulation of Toll-like_receptor_4 expression on blood CD14 -LRB- + -RRB- monocytes by simvastatin in patients with sepsis and severe_sepsis .
14572638	0	CD14	112,116	alpha-Melanocyte-stimulating_hormone	0,36	CD14	alpha-Melanocyte-stimulating hormone	929	5443	Gene	Gene	downregulating|dobj|START_ENTITY inhibits|advcl|downregulating inhibits|nsubj|END_ENTITY	alpha-Melanocyte-stimulating_hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages .
17448722	0	CD14	29,33	alpha1-Antitrypsin	0,18	CD14	alpha1-Antitrypsin	929	5265	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro .
17440807	0	CD14	96,100	cluster_of_differentiation_14	65,94	CD14	cluster of differentiation 14	929	929	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning , mapping , and tissue expression of the porcine cluster_of_differentiation_14 -LRB- CD14 -RRB- gene .
8555479	0	CD14	0,4	granulocyte_colony-stimulating_factor	15,52	CD14	granulocyte colony-stimulating factor	929	1440	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	CD14 + cells in granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow_stroma .
23508573	0	CD14	100,104	high_mobility_group_box_1	13,38	CD14	high mobility group box 1	929	3146	Gene	Gene	Signaling|nsubj|START_ENTITY Signaling|nmod|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
16019559	0	CD14	26,30	hoxC4	12,17	CD14	hoxC4	929	3221	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Upregulated hoxC4 induces CD14 expression during the differentiation of acute_promyelocytic_leukemia cells .
23416151	0	CD14	11,15	iNOS	29,33	CD14	iNOS	12475(Tax:10090)	18126(Tax:10090)	Gene	Gene	START_ENTITY|acl|activated activated|nmod|END_ENTITY	Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral_ischemia .
8945531	0	CD14	8,12	intercellular_adhesion_molecule_1	49,82	CD14	intercellular adhesion molecule 1	929	3383	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Soluble CD14 mediates lipopolysaccharide-induced intercellular_adhesion_molecule_1 expression in cultured human_gingival_fibroblasts .
12414752	0	CD14	88,92	interleukin-10	148,162	CD14	interleukin-10	929	3586	Gene	Gene	expression|nmod|START_ENTITY lipopolysaccharide|dobj|expression lipopolysaccharide|nmod|utilization utilization|nmod|END_ENTITY	Nef protein of human immunodeficiency virus and lipopolysaccharide induce expression of CD14 on human monocytes through differential utilization of interleukin-10 .
16148556	0	CD14	75,79	interleukin-10	59,73	CD14	interleukin-10	929	3586	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Are genetic polymorphisms of tumour necrosis factor alpha , interleukin-10 , CD14 endotoxin receptor or manganese_superoxide dismutase associated with alcoholic liver_disease ?
23469772	0	CD14	35,39	interleukin-6	12,25	CD14	interleukin-6	929	3569	Gene	Gene	START_ENTITY|amod|soluble soluble|amod|END_ENTITY	Circulating interleukin-6 , soluble CD14 , and other inflammation biomarker levels differ between obese and nonobese_HIV-infected adults on antiretroviral therapy .
11854210	0	CD14	15,19	interleukin-8	87,100	CD14	interleukin-8	929	3576	Gene	Gene	fibroblasts|nsubj|START_ENTITY fibroblasts|xcomp|primed primed|nmod|production production|nmod|END_ENTITY	Human gingival CD14 -LRB- + -RRB- fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression .
11854210	0	CD14	169,173	interleukin-8	87,100	CD14	interleukin-8	929	3576	Gene	Gene	up-regulation|nmod|START_ENTITY lipopolysaccharide|nmod|up-regulation production|acl|lipopolysaccharide production|nmod|END_ENTITY	Human gingival CD14 -LRB- + -RRB- fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression .
12011031	0	CD14	15,19	interleukin-8	179,192	CD14	interleukin-8	929	3576	Gene	Gene	Proteolysis|nmod|START_ENTITY proteinases|nsubj|Proteolysis proteinases|nmod|Porphyromonas_gingivalis Porphyromonas_gingivalis|acl|leading leading|nmod|down-regulation down-regulation|nmod|production production|amod|END_ENTITY	Proteolysis of CD14 on human_gingival_fibroblasts by arginine-specific cysteine proteinases from Porphyromonas_gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production .
12831455	0	CD14	166,170	interleukin-8	75,88	CD14	interleukin-8	929	3576	Gene	Gene	expression|amod|START_ENTITY up-regulation|nmod|expression accompanied|nmod|up-regulation accompanied|nsubjpass|effects effects|nmod|lipopolysaccharide lipopolysaccharide|acl|inducing inducing|dobj|production production|amod|END_ENTITY	Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14 , Toll-like_receptor_4 , MD-2 and MyD88 expression .
14500479	0	CD14	149,153	interleukin-8	114,127	CD14	interleukin-8	929	3576	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Augmentation of Actinobacillus_actinomycetemcomitans invasion of human oral epithelial cells and up-regulation of interleukin-8 production by saliva CD14 .
15358661	0	CD14	18,22	interleukin-8	53,66	CD14	interleukin-8	929	3576	Gene	Gene	important|nsubj|START_ENTITY important|nmod|induction induction|nmod|END_ENTITY	Membrane-anchored CD14 is important for induction of interleukin-8 by lipopolysaccharide and peptidoglycan in uroepithelial cells .
17093102	0	CD14	38,42	interleukin-8	89,102	CD14	interleukin-8	929	3576	Gene	Gene	receptor|compound|START_ENTITY glucuronoxylomannan|nmod|receptor Binding|nmod|glucuronoxylomannan induces|nsubj|Binding induces|dobj|production production|amod|END_ENTITY	Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production .
9632564	0	CD14	40,44	interleukin-8	111,124	CD14	interleukin-8	929	3576	Gene	Gene	expression|nmod|START_ENTITY expression|dep|secretion secretion|amod|END_ENTITY	Heterogeneous expression and release of CD14 by human_gingival_fibroblasts : characterization and CD14-mediated interleukin-8 secretion in response to lipopolysaccharide .
9784544	0	CD14	48,52	interleukin-8	79,92	CD14	interleukin-8	929	3576	Gene	Gene	release|compound|START_ENTITY release|acl|END_ENTITY	Helicobacter_pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8 , epithelial_neutrophil-activating_peptide_78 , and monocyte_chemotactic_protein_1 by human monocytes .
12404174	0	CD14	45,49	toll-like_receptor_4	6,26	CD14	toll-like receptor 4	929	7099	Gene	Gene	polymorphisms|nummod|START_ENTITY mutations|nmod|polymorphisms mutations|amod|END_ENTITY	Human toll-like_receptor_4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections .
18976692	0	CD14	25,29	toll-like_receptor_4	33,53	CD14	toll-like receptor 4	12475(Tax:10090)	21898(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|neuropathic_pain neuropathic_pain|amod|END_ENTITY	The contributing role of CD14 in toll-like_receptor_4 dependent neuropathic_pain .
23508573	0	CD14	100,104	toll-like_receptor_4	55,75	CD14	toll-like receptor 4	929	7099	Gene	Gene	Signaling|nsubj|START_ENTITY Signaling|nmod|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
8614033	0	CD14	8,12	tumor_necrosis_factor	70,91	CD14	tumor necrosis factor	12475(Tax:10090)	21926(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|response response|compound|END_ENTITY	Role of CD14 in hemorrhagic_shock-induced alterations of the monocyte tumor_necrosis_factor response to endotoxin .
20479116	0	CD141	6,11	BDCA-3	14,20	CD141	BDCA-3	7056	7056	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Human CD141 + -LRB- BDCA-3 -RRB- + dendritic cells -LRB- DCs -RRB- represent a unique myeloid DC subset that cross-presents necrotic cell antigens .
20479115	0	CD141	75,80	CD11c	69,74	CD141	CD11c	7056	3687	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Superior antigen cross-presentation and XCR1 expression define human CD11c + CD141 + cells as homologues of mouse CD8 + dendritic cells .
22547651	0	CD141	9,14	IL-10	62,67	CD141	IL-10	7056	3586	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|produce produce|dobj|END_ENTITY	Resident CD141 -LRB- BDCA3 -RRB- + dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin_inflammation .
18728246	0	CD143	45,50	angiotensin-converting_enzyme	14,43	CD143	angiotensin-converting enzyme	1636	1636	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of angiotensin-converting_enzyme -LRB- CD143 -RRB- identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells .
10487846	0	CD144	53,58	CD31	30,34	CD144	CD31	1003	5175	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	Functional roles for PECAM-1 -LRB- CD31 -RRB- and VE-cadherin -LRB- CD144 -RRB- in tube assembly and lumen formation in three-dimensional collagen gels .
22214418	0	CD144	29,34	CD34	23,27	CD144	CD34	1003	947	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	Decreased pre-surgical CD34 + / CD144 + cell number in patients undergoing coronary artery bypass grafting compared to coronary_artery_disease-free valvular patients .
25542764	0	CD144	6,11	CD34	0,4	CD144	CD34	1003	947	Gene	Gene	+|compound|START_ENTITY Circulating|nsubj|+ +|parataxis|Circulating +|compound|END_ENTITY	CD34 + / CD144 + Circulating Endothelial Cells as an Indicator of Carotid_Atherosclerosis .
15356072	0	CD146	26,31	Adiponectin	0,11	CD146	Adiponectin	4162	9370	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Adiponectin is related to CD146 , a novel marker of endothelial cell activation/injury in chronic_renal_failure and peritoneally dialyzed patients .
25275584	0	CD146	19,24	CDCP1	0,5	CD146	CDCP1	4162	64866	Gene	Gene	subset|compound|START_ENTITY identifies|dobj|subset identifies|nsubj|END_ENTITY	CDCP1 identifies a CD146 negative subset of marrow fibroblasts involved with cytokine production .
25058615	0	CD146	58,63	IL-17A	0,6	CD146	IL-17A	4162	3605	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	IL-17A production in human psoriatic blood and lesions by CD146 + T cells .
25595133	0	CD146	65,70	MCAM	59,63	CD146	MCAM	4162	4162	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Endothelial-binding , proinflammatory T cells identified by MCAM -LRB- CD146 -RRB- expression : Characterization and role in human autoimmune_diseases .
10726166	0	CD146	14,19	MUC18	40,45	CD146	MUC18	4162	4162	Gene	Gene	molecules|compound|START_ENTITY Expression|nmod|molecules Expression|appos|END_ENTITY	Expression of CD146 adhesion molecules -LRB- MUC18 or MCAM -RRB- in the thymic microenvironment .
24335906	0	CD146	11,16	Wnt5a	0,5	CD146	Wnt5a	338313(Tax:7955)	568191(Tax:7955)	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension .
17982057	0	CD146	52,57	melanoma_cell_adhesion_molecule	13,44	CD146	melanoma cell adhesion molecule	4162	4162	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Dual role of melanoma_cell_adhesion_molecule -LRB- MCAM -RRB- / CD146 in lymphocyte endothelium interaction : MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor .
23622764	0	CD147	0,5	ABCG2	68,73	CD147	ABCG2	682	9429	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function .
26716413	0	CD147	0,5	Annexin_A2	61,71	CD147	Annexin A2	682	302	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CD147 regulates cancer migration via direct interaction with Annexin_A2 and DOCK3-b-catenin-WAVE2 signaling .
20650803	0	CD147	20,25	Bcl-2	77,82	CD147	Bcl-2	682	596	Gene	Gene	expression|compound|START_ENTITY Down-regulation|nmod|expression induces|nsubj|Down-regulation induces|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Down-regulation of CD147 expression induces SiHa cell apoptosis through the Bcl-2 pathway -RSB- .
25996258	0	CD147	25,30	Bcl-2	16,21	CD147	Bcl-2	682	596	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis .
25327598	0	CD147	1,6	CD147	55,60	CD147	CD147	682	682	Gene	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	-LSB- CD147 expression level and rs8259 T/A polymorphism of CD147 in patients with acute_coronary_syndrome -RSB- .
25327598	0	CD147	55,60	CD147	1,6	CD147	CD147	682	682	Gene	Gene	level|nmod|START_ENTITY level|compound|END_ENTITY	-LSB- CD147 expression level and rs8259 T/A polymorphism of CD147 in patients with acute_coronary_syndrome -RSB- .
26891801	0	CD147	67,72	E2F1	0,4	CD147	E2F1	682	1869	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate_cancer .
17114117	0	CD147	31,36	EMMPRIN	22,29	CD147	EMMPRIN	682	682	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of EMMPRIN -LRB- CD147 -RRB- in the human eye and detection of soluble form of EMMPRIN in ocular fluids .
19863615	0	CD147	9,14	EMMPRIN	0,7	CD147	EMMPRIN	682	682	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- expression and differentiation of papillary thyroid_carcinoma : implications for immunocytochemistry in FNA cytology .
25824988	0	CD147	23,28	EMMPRIN	14,21	CD147	EMMPRIN	682	682	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of EMMPRIN -LRB- CD147 -RRB- on monocyte subsets in patients with symptomatic coronary_artery_disease .
20107538	0	CD147	19,24	ERK	58,61	CD147	ERK	682	5594	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages : Implication for Atherosclerosis .
20847954	0	CD147	14,19	ERK	80,83	CD147	ERK	682	5594	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|nmod|END_ENTITY	Activation of CD147 with cyclophilin_a induces the expression of IFITM1 through ERK and PI3K in THP-1 cells .
25996258	0	CD147	25,30	ERK	39,42	CD147	ERK	682	5594	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis .
17965264	0	CD147	47,52	Extracellular_matrix_metalloproteinase_inducer	0,46	CD147	Extracellular matrix metalloproteinase inducer	682	682	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Extracellular_matrix_metalloproteinase_inducer / CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction : implications in tissue remodeling .
25510296	0	CD147	0,5	IgAN	54,58	CD147	IgAN	682	60498	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	CD147 renal expression as a biomarker for progressive IgAN .
25901202	0	CD147	21,26	LAT1	70,74	CD147	LAT1	682	8140	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	Relationship between CD147 and expression of amino_acid transporters -LRB- LAT1 and ASCT2 -RRB- in patients with pancreatic_cancer .
10921872	0	CD147	0,5	MCT1	54,58	CD147	MCT1	682	6566	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression .
16901736	0	CD147	14,19	MCT1	53,57	CD147	MCT1	100141312(Tax:9823)	780423(Tax:9823)	Gene	Gene	Expression|nmod|START_ENTITY transporters|nsubj|Expression transporters|dobj|END_ENTITY	Expression of CD147 and monocarboxylate transporters MCT1 , MCT2 and MCT4 in porcine small intestine and colon .
21930917	0	CD147	0,5	MCT1	39,43	CD147	MCT1	682	6566	Gene	Gene	subunit|nummod|START_ENTITY subunit|nmod|END_ENTITY	CD147 subunit of lactate/H + symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic_tumors .
22281667	0	CD147	73,78	MCT1	48,52	CD147	MCT1	682	6566	Gene	Gene	monocarboxylate_transporter_1|appos|START_ENTITY monocarboxylate_transporter_1|appos|END_ENTITY	Co-expression of monocarboxylate_transporter_1 -LRB- MCT1 -RRB- and its chaperone -LRB- CD147 -RRB- is associated with low survival in patients with gastrointestinal_stromal_tumors -LRB- GISTs -RRB- .
24013424	0	CD147	0,5	MCT1	34,38	CD147	MCT1	682	6566	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	CD147 regulates the expression of MCT1 and lactate export in multiple_myeloma cells .
15904490	0	CD147	15,20	MMP-2	42,47	CD147	MMP-2	682	4313	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|overexpression overexpression|nmod|END_ENTITY	Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1 .
24996644	0	CD147	20,25	MMP-2	35,40	CD147	MMP-2	682	4313	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular_carcinoma .
18567920	0	CD147	86,91	MMP-9	27,32	CD147	MMP-9	682	4318	Gene	Gene	monocytes/macrophages|nmod|START_ENTITY expression|nmod|monocytes/macrophages expression|compound|END_ENTITY	Cyclophilin_A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid_arthritis .
20107538	0	CD147	19,24	MMP-9	33,38	CD147	MMP-9	682	4318	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages : Implication for Atherosclerosis .
20473759	0	CD147	189,194	MMP-9	182,187	CD147	MMP-9	682	4318	Gene	Gene	MMP-2|nummod|START_ENTITY MMP-2|nummod|END_ENTITY	Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2 , MMP-9 , CD147 .
21355964	0	CD147	9,14	MMP-9	30,35	CD147	MMP-9	682	4318	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- regulation of MMP-9 in bronchial epithelial cells in COPD .
23536308	0	CD147	27,32	MMP-9	116,121	CD147	MMP-9	682	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|downregulating downregulating|dobj|END_ENTITY	RNA interference targeting CD147 inhibits the invasion of human cervical squamous_carcinoma cells by downregulating MMP-9 .
23292863	0	CD147	0,5	MMP9	7,11	CD147	MMP9	682	4318	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	CD147 , MMP9 expression and clinical significance of basal-like breast_cancer .
25470292	0	CD147	0,5	NDUFS6	21,27	CD147	NDUFS6	682	4726	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	CD147 Interacts with NDUFS6 in Regulating Mitochondrial Complex I Activity and the Mitochondrial Apoptotic Pathway in Human Malignant_Melanoma Cells .
20384626	0	CD147	76,81	Sp1	21,24	CD147	Sp1	682	6667	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung_cancer .
20629990	0	CD147	38,43	Sp1	74,77	CD147	Sp1	682	6667	Gene	Gene	START_ENTITY|advcl|increasing increasing|dobj|binding binding|amod|END_ENTITY	Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular_carcinoma .
22192282	0	CD147	87,92	extracellular_matrix_metalloproteinase_inducer	39,85	CD147	extracellular matrix metalloproteinase inducer	682	682	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Intracoronary upregulation of platelet extracellular_matrix_metalloproteinase_inducer -LRB- CD147 -RRB- in coronary_disease .
18379992	0	CD147	0,5	vascular_endothelial_growth_factor-A	16,52	CD147	vascular endothelial growth factor-A	12215(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	CD147 regulates vascular_endothelial_growth_factor-A expression , tumorigenicity , and chemosensitivity to curcumin in hepatocellular_carcinoma .
12886247	0	CD15	156,160	CD10	131,135	CD15	CD10	2526	24590(Tax:10116)	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Expression of the human homologue of rat NG2 in adult acute_lymphoblastic_leukemia : close association with MLL rearrangement and a CD10 -LRB- - -RRB- / CD24 -LRB- - -RRB- / CD65s -LRB- + -RRB- / CD15 -LRB- + -RRB- B-cell phenotype .
19041316	0	CD15	72,76	CD11b	65,70	CD15	CD11b	2526	3684	Gene	Gene	granulocytes|compound|START_ENTITY granulocytes|compound|END_ENTITY	Delayed processing of blood increases the frequency of activated CD11b + CD15 + granulocytes which inhibit T cell function .
19369244	0	CD15	17,21	CD11b	10,15	CD15	CD11b	2526	3684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activated CD11b + CD15 + granulocytes increase in the blood of patients with uveal_melanoma .
19572148	0	CD15	99,103	CD11b	84,89	CD15	CD11b	2526	3684	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|nsubj|alterations alterations|nmod|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
9335318	0	CD15	38,42	CD11b	43,48	CD15	CD11b	2526	3684	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nummod|+	Characterization of a culture-derived CD15 + CD11b - promyelocytic population from CD34 + peripheral blood cells .
21803487	0	CD15	75,79	CD133	68,73	CD15	CD133	2526	8842	Gene	Gene	compartment|compound|START_ENTITY compartment|compound|END_ENTITY	Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133 + / CD15 + cell compartment and the in vitro tumorigenic capability of neuroblastoma cells .
19572148	0	CD15	99,103	CD14	91,95	CD15	CD14	2526	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
12886247	0	CD15	156,160	CD24	139,143	CD15	CD24	2526	25145(Tax:10116)	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Expression of the human homologue of rat NG2 in adult acute_lymphoblastic_leukemia : close association with MLL rearrangement and a CD10 -LRB- - -RRB- / CD24 -LRB- - -RRB- / CD65s -LRB- + -RRB- / CD15 -LRB- + -RRB- B-cell phenotype .
23988031	0	CD15	106,110	CD30	112,116	CD15	CD30	2526	943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF2 -RRB- and syndecan-1 -LRB- SDC1 -RRB- are potential biomarkers for putative circulating CD15 + / CD30 + cells in poor outcome Hodgkin_lymphoma patients .
9327746	7	CD15	764,768	CD30	771,775	CD30	CD20	943	54474	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Eighty-three percent of the cases showed a classical immunophenotype -LRB- CD15 + , CD30 + , CD20 - -RRB- , twelve percent lacked CD15 positivity -LRB- CD15 - , CD30 + , CD20 - -RRB- , and five percent showed other combinations .
19572148	0	CD15	99,103	CD33	105,109	CD15	CD33	2526	945	Gene	Gene	+|compound|START_ENTITY +|parataxis|lymphocytes lymphocytes|nsubj|cells cells|nummod|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
24441947	0	CD15	54,58	CD34	60,64	CD15	CD34	2526	947	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Normal karyotype acute_myeloid_leukemia with the CD7 + CD15 + CD34 + HLA-DR + immunophenotype is a clinically distinct entity with a favorable outcome .
9335318	0	CD15	38,42	CD34	80,84	CD15	CD34	2526	947	Gene	Gene	+|compound|START_ENTITY CD11b|nummod|+ Characterization|nmod|CD11b Characterization|dep|population population|nmod|cells cells|nummod|END_ENTITY	Characterization of a culture-derived CD15 + CD11b - promyelocytic population from CD34 + peripheral blood cells .
24441947	0	CD15	54,58	CD7	49,52	CD15	CD7	2526	924	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Normal karyotype acute_myeloid_leukemia with the CD7 + CD15 + CD34 + HLA-DR + immunophenotype is a clinically distinct entity with a favorable outcome .
20231852	0	CD150	0,5	JNK1/2	16,22	CD150	JNK1/2	6504	5599;5601	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	CD150 regulates JNK1/2 activation in normal and Hodgkin 's _ lymphoma B cells .
12242590	0	CD150	47,52	Ly9	12,15	CRACC	Ly9	75345(Tax:10090)	17085(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	Mouse novel Ly9 : a new member of the expanding CD150 -LRB- SLAM -RRB- family of leukocyte cell-surface receptors .
11313386	0	CD150	0,5	SH2-containing_inositol_phosphatase	34,69	CD150	SH2-containing inositol phosphatase	6504	3635	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	CD150 association with either the SH2-containing_inositol_phosphatase or the SH2-containing_protein_tyrosine_phosphatase is regulated by the adaptor protein SH2D1A .
20933013	0	CD150	20,25	SLAM	14,18	CD150	SLAM	6504	6504	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of SLAM -LRB- CD150 -RRB- cell-surface receptors on human B-cell subsets : from pro-B to plasma cells .
24495805	0	CD151	87,92	MiR-22	0,6	CD151	MiR-22	977	407004	Gene	Gene	inhibiting|dobj|START_ENTITY suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	MiR-22 suppresses the proliferation and invasion of gastric_cancer cells by inhibiting CD151 .
19509057	0	CD151	12,17	RhoA	28,32	CD151	RhoA	977	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts .
16139245	0	CD151	0,5	c-Met	38,43	CD151	c-Met	977	4233	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	CD151 forms a functional complex with c-Met in human salivary_gland_cancer cells .
20578262	0	CD151	0,5	matrix_metalloproteinase_9	30,56	CD151	matrix metalloproteinase 9	977	4318	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	CD151 modulates expression of matrix_metalloproteinase_9 and promotes neoangiogenesis and progression of hepatocellular_carcinoma .
14662196	0	CD152	20,25	CD25	14,18	CD152	CD25	1493	3559	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Evaluation of CD25 , CD152 , Fas-ligand expression in the adenoids of allergic and non-allergic children : a pilot study .
22749982	0	CD152	13,18	CD25	66,70	CD152	CD25	1493	3559	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22749982	0	CD152	13,18	CD4	61,64	CD152	CD4	1493	920	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|CD25 CD25|compound|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
10193417	0	CD152	31,36	CTLA-4	23,29	CD152	CTLA-4	1493	1493	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of CTLA-4 -LRB- CD152 -RRB- on CD4 + T cells in HIV_infection .
17020649	0	CD152	13,18	CTLA-4	20,26	CD152	CTLA-4	1493	1493	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- The surface CD152 -LRB- CTLA-4 -RRB- expression on peripheral blood lymphocytes in children with Hashimoto 's _ thyroiditis -RSB- .
20134044	0	CD152	14,19	CTLA-4	21,27	CD152	CTLA-4	1493	1493	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD152 -LRB- CTLA-4 -RRB- in children with autoimmune_thyroiditis and +49 _ A/G polymorphism of exon 1 of the CTLA-4 gene .
9749982	0	CD152	22,27	CTLA-4	14,20	CD152	CTLA-4	1493	1493	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CTLA-4 -LRB- CD152 -RRB- on human medullary CD4 + thymocytes .
19224637	0	CD152	0,5	Eomesodermin	80,92	CD152	Eomesodermin	1493	8320	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	CD152 -LRB- CTLA-4 -RRB- regulates effector functions of CD8 + T lymphocytes by repressing Eomesodermin .
14662196	0	CD152	20,25	Fas-ligand	27,37	CD152	Fas-ligand	1493	356	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Evaluation of CD25 , CD152 , Fas-ligand expression in the adenoids of allergic and non-allergic children : a pilot study .
22749982	0	CD152	13,18	Foxp3	54,59	CD152	Foxp3	1493	50943	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
10080930	0	CD153	27,32	CD30	14,18	CD153	CD30	21949(Tax:10090)	21941(Tax:10090)	Gene	Gene	cells|dep|START_ENTITY ligand|nmod|cells ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD30 ligand -LRB- CD153 -RRB- on murine activated T cells .
10878352	0	CD153	14,19	CD30	37,41	CD153	CD30	944	943	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Engagement of CD153 -LRB- CD30_ligand -RRB- by CD30 + T cells inhibits class switch DNA recombination and antibody production in human IgD + IgM + B cells .
11754357	0	CD153	22,27	CD30	8,12	CD153	CD30	944	943	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30 .
11754357	0	CD153	22,27	CD30	85,89	CD153	CD30	944	943	Gene	Gene	START_ENTITY|nmod|affinity affinity|acl|signaling signaling|nmod|END_ENTITY	Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30 .
12392508	0	CD153	44,49	CD30	31,35	CD153	CD30	21949(Tax:10090)	21941(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|murine murine|dep|END_ENTITY	Characterization of the murine CD30 ligand -LRB- CD153 -RRB- gene : gene structure and expression .
17237414	0	CD154	42,47	CD154	73,78	CD154	CD154	959	959	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4 -LRB- + -RRB- T cells from HIV-1-infected patients .
17237414	0	CD154	73,78	CD154	42,47	CD154	CD154	959	959	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Role of CD40-dependent down-regulation of CD154 in impaired induction of CD154 in CD4 -LRB- + -RRB- T cells from HIV-1-infected patients .
10684857	0	CD154	13,18	CD4	42,45	CD154	CD4	959	920	Gene	Gene	triggers|nsubj|START_ENTITY triggers|dobj|response response|compound|T T|compound|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- triggers a short-term CD4 -LRB- + -RRB- T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis .
10700427	0	CD154	37,42	CD4	47,50	CD154	CD4	959	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Increased expression of CD40 ligand -LRB- CD154 -RRB- on CD4 + T cells as a marker of disease activity in rheumatoid_arthritis .
10725703	0	CD154	24,29	CD4	54,57	CD154	CD4	959	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells .
10940889	0	CD154	123,128	CD4	144,147	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
12618479	0	CD154	56,61	CD4	18,21	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY role|nmod|source role|nmod|cells cells|compound|END_ENTITY	A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes_mellitus in the non-obese diabetic mouse .
12857968	0	CD154	0,5	CD4	50,53	CD154	CD4	959	920	Gene	Gene	transcriptional|nsubj|START_ENTITY transcriptional|dobj|regulation regulation|nmod|cells cells|compound|END_ENTITY	CD154 transcriptional regulation in primary human CD4 T cells .
14627918	0	CD154	0,5	CD4	24,27	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|surface surface|nmod|cells cells|compound|END_ENTITY	CD154 on the surface of CD4 + CD25 + regulatory T cells contributes to skin transplant tolerance .
14645155	0	CD154	10,15	CD4	39,42	CD154	CD4	959	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Decreased CD154 expression by neonatal CD4 + T cells is due to limitations in both proximal and distal events of T cell activation .
14702154	0	CD154	31,36	CD4	52,55	CD154	CD4	959	920	Gene	Gene	induction|nmod|START_ENTITY impaired|nsubjpass|induction impaired|nmod|cells cells|compound|END_ENTITY	Pathogen-specific induction of CD154 is impaired in CD4 + T cells from human_immunodeficiency_virus-infected patients .
15147360	0	CD154	12,17	CD4	42,45	CD154	CD4	959	920	Gene	Gene	intensity|compound|START_ENTITY Decrease|nmod|intensity Decrease|nmod|cells cells|compound|END_ENTITY	Decrease of CD154 intensity on peripheral CD4 + T cells in autoimmune_thyroid_disease .
16186818	0	CD154	73,78	CD4	17,20	CD154	CD4	959	920	Gene	Gene	expression|compound|START_ENTITY antigens|nmod|expression antigens|nsubj|access access|nmod|cells cells|compound|END_ENTITY	Direct access to CD4 + T cells specific for defined antigens according to CD154 expression .
16670307	0	CD154	77,82	CD4	0,3	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY independent|nsubj|blockade induction|advcl|independent induction|nsubj|cell cell|compound|END_ENTITY	CD4 + T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent .
17406204	0	CD154	68,73	CD4	43,46	CD154	CD4	959	920	Gene	Gene	expression|compound|START_ENTITY detect|nmod|expression detect|dobj|responses responses|compound|END_ENTITY	Live-cell assay to detect antigen-specific CD4 + T-cell responses by CD154 expression .
18383039	0	CD154	92,97	CD4	11,14	CD154	CD4	473802(Tax:9598)	920	Gene	Gene	up-regulation|compound|START_ENTITY inhibition|nmod|up-regulation HIV-1|dobj|inhibition insensitive|xcomp|HIV-1 insensitive|nsubj|cells cells|compound|END_ENTITY	Chimpanzee CD4 + T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation .
18606661	0	CD154	29,34	CD4	17,20	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY help|nmod|activation help|nsubj|role role|nmod|END_ENTITY	Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients .
18785645	0	CD154	87,92	CD4	107,110	CD154	CD4	959	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	The influence of different stimulation conditions on the assessment of antigen-induced CD154 expression on CD4 + T cells .
19572319	0	CD154	43,48	CD4	58,61	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY T|nmod|regulation T|nsubj|+ +|compound|END_ENTITY	In vivo post-transcriptional regulation of CD154 in mouse CD4 + T cells .
20506525	0	CD154	101,106	CD4	33,36	CD154	CD4	959	920	Gene	Gene	transcription|compound|START_ENTITY increased|nmod|transcription increased|nsubj|expression expression|nmod|CD154 CD154|nmod|cells cells|compound|END_ENTITY	Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription , increased nuclear factor of activated T cell activity , and glomerulonephritis .
20506525	0	CD154	24,29	CD4	33,36	CD154	CD4	959	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription , increased nuclear factor of activated T cell activity , and glomerulonephritis .
20713889	0	CD154	151,156	CD4	55,58	CD154	CD4	959	920	Gene	Gene	upregulation|compound|START_ENTITY inhibiting|dobj|upregulation Y|advcl|inhibiting confer|dep|Y confer|nsubj|splenocytes splenocytes|acl|carrying carrying|dobj|epitopes epitopes|compound|END_ENTITY	Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation .
21496498	0	CD154	35,40	CD4	56,59	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|subset subset|nmod|cells cells|compound|END_ENTITY	Stimulation-dependent induction of CD154 on a subset of CD4 + FoxP3 + T-regulatory cells .
21692946	0	CD154	0,5	CD4	51,54	CD154	CD4	959	920	Gene	Gene	START_ENTITY|appos|marker marker|nmod|stimulation stimulation|nmod|cells cells|compound|END_ENTITY	CD154 , a marker of antigen-specific stimulation of CD4 T cells , is associated with response to treatment in patients with chronic HCV_infection .
22689014	0	CD154	33,38	CD4	42,45	CD154	CD4	959	920	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Inhibition of activation induced CD154 on CD4 + CD25 - cells : a valid surrogate for human Treg suppressor function .
23071696	0	CD154	0,5	CD4	28,31	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|cells cells|compound|END_ENTITY	CD154 and IL-2 signaling of CD4 + T cells play a critical role in multiple phases of CD8 + CTL responses following adenovirus vaccination .
24500400	0	CD154	15,20	CD4	41,44	CD154	CD4	959	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24500400	0	CD154	78,83	CD4	41,44	CD154	CD4	959	920	Gene	Gene	promoter|compound|START_ENTITY binding|nmod|promoter binding|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24777309	0	CD154	0,5	CD4	7,10	CD154	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	dependence|compound|START_ENTITY dependence|compound|END_ENTITY	CD154 + CD4 + T-cell dependence for effective memory influenza virus-specific CD8 + T-cell responses .
9691083	0	CD154	80,85	CD4	0,3	CD154	CD4	959	920	Gene	Gene	CD40L|dep|START_ENTITY ligand|dep|CD40L antibody|amod|ligand tolerized|nmod|antibody T|acl:relcl|tolerized T|compound|END_ENTITY	CD4 -LRB- + -RRB- T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand -LRB- CD40L : CD154 -RRB- antibody lose their graft-versus-host_disease lethality capacity but retain nominal antigen responses .
9826442	0	CD154	15,20	CD4	67,70	CD154	CD4	959	920	Gene	Gene	TNF-alpha|appos|START_ENTITY plays|nsubj|TNF-alpha T|ccomp|plays T|nsubj|END_ENTITY	TNF-alpha , not CD154 -LRB- CD40L -RRB- , plays a major role in SEB-dependent , CD4 -LRB- + -RRB- T cell-induced endothelial cell activation in vitro .
10452982	0	CD154	14,19	CD40	20,24	CD154	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	Disruption|nmod|START_ENTITY Disruption|dep|generation generation|compound|END_ENTITY	Disruption of CD154 : CD40 blocks generation of allograft immunity without affecting APC activation .
10491009	0	CD154	32,37	CD40	19,23	CD154	CD40	959	958	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Hyperexpression Hyperexpression|nmod|END_ENTITY	Hyperexpression of CD40 ligand -LRB- CD154 -RRB- in inflammatory_bowel_disease and its contribution to pathogenic cytokine production .
10510356	0	CD154	70,75	CD40	57,61	CD154	CD40	959	958	Gene	Gene	turnover|appos|START_ENTITY ligand|dobj|turnover ligand|nsubj|Characterization Characterization|nmod|proteins proteins|acl|associated associated|nmod|END_ENTITY	Characterization of RNA binding proteins associated with CD40 ligand -LRB- CD154 -RRB- mRNA turnover in human T lymphocytes .
10513352	0	CD154	9,14	CD40	16,20	CD154	CD40	959	958	Gene	Gene	synthesis|nsubj|START_ENTITY synthesis|parataxis|ligand ligand|nsubj|END_ENTITY	Elevated CD154 -LRB- CD40 ligand -RRB- synthesis in T-cells from allergic patients after nonspecific stimulation in vitro .
10651941	0	CD154	148,153	CD40	121,125	CD154	CD40	959	958	Gene	Gene	block|dobj|START_ENTITY interferes|xcomp|block interferes|nmod|ability ability|nmod|END_ENTITY	A polymorphic CD40 ligand -LRB- CD154 -RRB- molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154 : CD40 interactions .
10651941	0	CD154	148,153	CD40	154,158	CD154	CD40	959	958	Gene	Gene	START_ENTITY|dep|interactions interactions|nummod|END_ENTITY	A polymorphic CD40 ligand -LRB- CD154 -RRB- molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154 : CD40 interactions .
10651941	0	CD154	27,32	CD40	14,18	CD154	CD40	959	958	Gene	Gene	molecule|appos|START_ENTITY molecule|amod|polymorphic polymorphic|dep|END_ENTITY	A polymorphic CD40 ligand -LRB- CD154 -RRB- molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154 : CD40 interactions .
10684857	0	CD154	13,18	CD40	0,4	CD154	CD40	959	958	Gene	Gene	triggers|nsubj|START_ENTITY ligand|ccomp|triggers ligand|nsubj|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- triggers a short-term CD4 -LRB- + -RRB- T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis .
10700427	0	CD154	37,42	CD40	24,28	CD154	CD40	959	958	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|expression expression|nmod|END_ENTITY	Increased expression of CD40 ligand -LRB- CD154 -RRB- on CD4 + T cells as a marker of disease activity in rheumatoid_arthritis .
10755553	0	CD154	82,87	CD40	45,49	CD154	CD40	959	397395(Tax:9823)	Gene	Gene	conserved|nmod|START_ENTITY END_ENTITY|nmod|conserved	High sequence homology between human and pig CD40 with conserved binding to human CD154 .
10856699	0	CD154	0,5	CD40	7,11	CD154	CD40	959	958	Gene	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	CD154 -LRB- CD40 ligand -RRB- .
10940889	0	CD154	123,128	CD40	110,114	CD154	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY induce|dep|expression induce|nmod|induction induction|nmod|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
11044648	0	CD154	45,50	CD40	23,27	CD154	CD40	959	958	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abundant expression of CD40 and CD40-ligand -LRB- CD154 -RRB- in paediatric Langerhans_cell_histiocytosis_lesions .
11168635	0	CD154	89,94	CD40	23,27	CD154	CD40	959	958	Gene	Gene	relative|nmod|START_ENTITY position|nmod|relative correlates|nmod|position correlates|nsubj|activity activity|nmod|antibodies antibodies|nummod|END_ENTITY	Functional activity of CD40 antibodies correlates to the position of binding relative to CD154 .
11187868	0	CD154	27,32	CD40	14,18	CD154	CD40	959	958	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of CD40 ligand -LRB- CD154 -RRB- in the treatment of factor VIII inhibitors .
11297266	0	CD154	42,47	CD40	29,33	CD154	CD40	959	958	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|effects effects|nmod|END_ENTITY	Growth-inhibitory effects of CD40 ligand -LRB- CD154 -RRB- and its endogenous expression in human breast_cancer .
11488594	0	CD154	55,60	CD40	42,46	CD154	CD40	959	958	Gene	Gene	trimer|appos|START_ENTITY trimer|amod|soluble soluble|dep|END_ENTITY	Biophysical characterization of a soluble CD40 ligand -LRB- CD154 -RRB- coiled-coil trimer : evidence of a reversible acid-denatured molten globule .
11493450	0	CD154	40,45	CD40	123,127	CD154	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY action|nmod|ligand limited|nsubj|action limited|nmod|END_ENTITY	The inflammatory action of CD40 ligand -LRB- CD154 -RRB- expressed on activated human platelets is temporally limited by coexpressed CD40 .
11493450	0	CD154	40,45	CD40	27,31	CD154	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY ligand|nummod|END_ENTITY	The inflammatory action of CD40 ligand -LRB- CD154 -RRB- expressed on activated human platelets is temporally limited by coexpressed CD40 .
11592086	0	CD154	107,112	CD40	56,60	CD154	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY forms|nmod|ligand using|dobj|forms END_ENTITY|acl|using	Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand , CD154 .
11676606	0	CD154	121,126	CD40	111,115	CD154	CD40	959	100770242	Gene	Gene	structures|nmod|START_ENTITY structures|amod|N-linked N-linked|nmod|CD154 CD154|nmod|interactions interactions|nmod|END_ENTITY	Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia_pastoris and Chinese_hamster ovary cells .
11676606	0	CD154	61,66	CD40	111,115	CD154	CD40	959	100770242	Gene	Gene	START_ENTITY|nmod|interactions interactions|nmod|END_ENTITY	Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia_pastoris and Chinese_hamster ovary cells .
11687447	0	CD154	22,27	CD40	9,13	CD154	CD40	959	958	Gene	Gene	expression|appos|START_ENTITY ligand|dobj|expression ligand|nsubj|END_ENTITY	Abnormal CD40 ligand -LRB- CD154 -RRB- expression in human_immunodeficiency_virus-infected children .
11705814	0	CD154	38,43	CD40	16,20	CD154	CD40	959	958	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of CD40 and CD40 ligand -LRB- CD154 -RRB- in patients with moderate hypercholesterolemia .
11815953	0	CD154	27,32	CD40	14,18	CD154	CD40	959	958	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD40 ligand -LRB- CD154 -RRB- in B and T lymphocytes of Hodgkin_disease : potential therapeutic significance .
11891278	0	CD154	89,94	CD40	51,55	CD154	CD40	959	958	Gene	Gene	therapy|compound|START_ENTITY activity|nmod|therapy explain|dobj|activity explain|nsubj|sensitivity sensitivity|nmod|apoptosis apoptosis|nmod|ligation ligation|compound|END_ENTITY	Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic_lymphocytic_leukemia .
11895332	0	CD154	53,58	CD40	40,44	CD154	CD40	493850(Tax:9685)	101085363	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|Demonstration Demonstration|nmod|activity activity|nmod|END_ENTITY	Demonstration of biological activity of CD40 ligand -LRB- CD154 -RRB- in the domestic_cat .
11929824	0	CD154	71,76	CD40	58,62	CD154	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY ligand|nummod|END_ENTITY	CD40-expressing carcinoma cells induce down-regulation of CD40 ligand -LRB- CD154 -RRB- and impair T-cell functions .
11986259	0	CD154	31,36	CD40	18,22	CD154	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	Levels of soluble CD40 ligand -LRB- CD154 -RRB- in serum are increased in human_immunodeficiency_virus_type_1-infected patients and correlate with CD4 -LRB- + -RRB- T-cell counts .
12517964	0	CD154	114,119	CD40	101,105	CD154	CD40	959	958	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	A complex containing polypyrimidine tract-binding protein is involved in regulating the stability of CD40 ligand -LRB- CD154 -RRB- mRNA .
12950679	0	CD154	35,40	CD40	22,26	CD154	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	CD40L|appos|START_ENTITY IFN-gamma|nsubj|CD40L IFN-gamma|nmod|expression expression|nmod|END_ENTITY	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
15780086	0	CD154	13,18	CD40	0,4	CD154	CD40	959	958	Gene	Gene	takes|nsubj|START_ENTITY ligand|ccomp|takes ligand|nsubj|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- takes part in regulation of the transition to mononuclear cell dominance during peritonitis .
15859239	0	CD154	58,63	CD40	45,49	CD154	CD40	959	958	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Conservation Conservation|nmod|properties properties|nmod|END_ENTITY	Conservation of biological properties of the CD40 ligand , CD154 in a non-mammalian vertebrate .
16777229	0	CD154	51,56	CD40	58,62	CD154	CD40	959	958	Gene	Gene	START_ENTITY|dep|ligand ligand|nsubj|END_ENTITY	Cloning , sequence analysis and expression of ovine CD154 -LRB- CD40 ligand -RRB- .
16893998	0	CD154	21,26	CD40	28,32	CD154	CD40	101789598	101793419	Gene	Gene	Immunotargeting|nmod|START_ENTITY Immunotargeting|parataxis|ligand ligand|nsubj|END_ENTITY	Immunotargeting with CD154 -LRB- CD40 ligand -RRB- enhances DNA vaccine responses in ducks .
17002639	0	CD154	39,44	CD40	26,30	CD154	CD40	959	958	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|association association|nmod|END_ENTITY	An association of soluble CD40 ligand -LRB- CD154 -RRB- with adverse reactions to platelet transfusions .
17075342	0	CD154	108,113	CD40	18,22	CD154	CD40	959	958	Gene	Gene	decreased|dep|START_ENTITY ligand|ccomp|decreased increased|advcl|ligand increased|nsubjpass|proportion proportion|nmod|macrophages macrophages|compound|END_ENTITY	The proportion of CD40 + mucosal macrophages is increased in inflammatory_bowel_disease whereas CD40 ligand -LRB- CD154 -RRB- + T cells are relatively decreased , suggesting differential modulation of these costimulatory molecules in human gut lamina propria .
17075342	0	CD154	108,113	CD40	95,99	CD154	CD40	959	958	Gene	Gene	decreased|dep|START_ENTITY ligand|ccomp|decreased ligand|nsubj|END_ENTITY	The proportion of CD40 + mucosal macrophages is increased in inflammatory_bowel_disease whereas CD40 ligand -LRB- CD154 -RRB- + T cells are relatively decreased , suggesting differential modulation of these costimulatory molecules in human gut lamina propria .
17225862	0	CD154	29,34	CD40	46,50	CD154	CD40	959	958	Gene	Gene	START_ENTITY|acl|preventing preventing|dobj|apoptosis apoptosis|nummod|END_ENTITY	C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis : a novel link between complement and epithelial cell survival .
18728056	0	CD154	53,58	CD40	40,44	CD154	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	The cardiovascular_risk factor , soluble CD40 ligand -LRB- CD154 -RRB- , but not soluble CD40 is lowered by ultra-endurance exercise in athletes .
18770718	0	CD154	28,33	CD40	15,19	CD154	CD40	959	958	Gene	Gene	expression|appos|START_ENTITY ligand|dobj|expression ligand|nsubj|Measurement Measurement|nmod|END_ENTITY	Measurement of CD40 ligand -LRB- CD154 -RRB- expression on resting and in vitro-activated T cells .
18941252	0	CD154	41,46	CD40	47,51	CD154	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	conditioning|dep|START_ENTITY conditioning|parataxis|promotes promotes|nsubj|blockade blockade|nummod|END_ENTITY	Strategic nonmyeloablative conditioning : CD154 : CD40 costimulatory blockade at primary bone marrow transplantation promotes engraftment for secondary bone marrow transplantation after engraftment failure .
19117935	0	CD154	91,96	CD40	85,89	CD154	CD40	959	958	Gene	Gene	hyperinduces|nummod|START_ENTITY fibroblasts|dep|hyperinduces fibroblasts|nmod|patients patients|nmod|END_ENTITY	Orbital fibroblasts from patients with thyroid-associated_ophthalmopathy overexpress CD40 : CD154 hyperinduces IL-6 , IL-8 , and MCP-1 .
19332074	0	CD154	28,33	CD40	85,89	CD154	CD40	959	958	Gene	Gene	molecules|nummod|START_ENTITY number|nmod|molecules Estimation|nmod|number used|nsubj|Estimation used|nmod|source source|nmod|stimulation stimulation|nummod|END_ENTITY	Estimation of the number of CD154 molecules in membrane extracts used as a source of CD40 stimulation of human B lymphocytes .
19656553	0	CD154	35,40	CD40	22,26	CD154	CD40	959	958	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|role role|nmod|END_ENTITY	The role of platelets CD40 ligand -LRB- CD154 -RRB- in acute_coronary_syndromes .
22139839	0	CD154	97,102	CD40	84,88	CD154	CD40	959	958	Gene	Gene	ligand|dep|START_ENTITY contribute|dep|ligand contribute|xcomp|BCL2 BCL2|nmod|END_ENTITY	miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand -LRB- CD154 -RRB- in human leukemic B-cells .
22295117	0	CD154	41,46	CD40	14,18	CD154	CD40	959	958	Gene	Gene	promotes|nsubj|START_ENTITY derived|ccomp|promotes derived|nsubj|Activation Activation|nmod|END_ENTITY	Activation of CD40 with platelet derived CD154 promotes reactive_oxygen_species dependent death of human hepatocytes during hypoxia and reoxygenation .
22703674	0	CD154	13,18	CD40	0,4	CD154	CD40	959	958	Gene	Gene	involvement|appos|START_ENTITY ligand|dobj|involvement ligand|nsubj|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- involvement in platelet transfusion reactions .
9422418	0	CD154	22,27	CD40	0,4	CD154	CD40	959	958	Gene	Gene	coexpressed|nsubjpass|START_ENTITY ligand|ccomp|coexpressed ligand|nsubj|END_ENTITY	CD40 and CD40 ligand -LRB- CD154 -RRB- are coexpressed on microvessels in vivo in human cardiac allograft rejection .
9550372	0	CD154	63,68	CD40	50,54	CD154	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|effects effects|nmod|END_ENTITY	Immunostimulatory effects of a plasmid expressing CD40 ligand -LRB- CD154 -RRB- on gene immunization .
9570530	0	CD154	32,37	CD40	19,23	CD154	CD40	959	958	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	IL-12 up-regulates CD40 ligand -LRB- CD154 -RRB- expression on human T cells .
11422428	0	CD154	31,36	CD40-ligand	38,49	CD154	CD40-ligand	959	959	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased T cell expression of CD154 -LRB- CD40-ligand -RRB- in multiple_sclerosis .
11127303	0	CD154	16,21	CD40L	23,28	CD154	CD40L	959	959	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The kinetics of CD154 -LRB- CD40L -RRB- expression in peripheral blood mononuclear cells of healthy subjects in liver allograft recipients and X-linked_hyper-IgM_syndrome .
17553339	0	CD154	21,26	CD40L	28,33	CD154	CD40L	959	959	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- Correlation between CD154 -LRB- CD40L -RRB- expression and naive/memory CD4 -LRB- + -RRB- T cells -RSB- .
19546834	0	CD154	51,56	CD40L	44,49	CD154	CD40L	21947(Tax:10090)	21947(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Increase of in vivo antitumoral activity by CD40L -LRB- CD154 -RRB- gene transfer into pancreatic_tumor cell-dendritic cell hybrids .
10201926	0	CD154	14,19	CD40_ligand	21,32	CD154	CD40 ligand	959	959	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of CD154 -LRB- CD40_ligand -RRB- mRNA stability during T cell activation .
10929069	0	CD154	24,29	CD40_ligand	31,42	CD154	CD40 ligand	959	959	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of functional CD154 -LRB- CD40_ligand -RRB- in neonatal T cells by cAMP-elevating agents .
11529914	0	CD154	43,48	CD40_ligand	50,61	CD154	CD40 ligand	959	959	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	NF-kappaB is involved in the regulation of CD154 -LRB- CD40_ligand -RRB- expression in primary human T cells .
14607202	0	CD154	19,24	CD40_ligand	26,37	CD154	CD40 ligand	959	959	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Enhanced levels of CD154 -LRB- CD40_ligand -RRB- on platelets in patients with chronic_heart_failure .
18640985	0	CD154	67,72	CD40_ligand	74,85	CD154	CD40 ligand	21947(Tax:10090)	21947(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Separate cis-trans pathways post-transcriptionally regulate murine CD154 -LRB- CD40_ligand -RRB- expression : a novel function for CA repeats in the 3 ' - untranslated region .
21496498	0	CD154	35,40	FoxP3	61,66	CD154	FoxP3	21947(Tax:10090)	20371(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|subset subset|nmod|cells cells|compound|END_ENTITY	Stimulation-dependent induction of CD154 on a subset of CD4 + FoxP3 + T-regulatory cells .
10725703	0	CD154	24,29	IL-2	0,4	CD154	IL-2	959	3558	Gene	Gene	expression|nummod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells .
10886401	0	CD154	46,51	Interleukin-15	0,14	CD154	Interleukin-15	959	3600	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Interleukin-15 up-regulates the expression of CD154 on synovial fluid T cells .
10949181	0	CD154	92,97	NFkappaB	128,136	CD154	NFkappaB	21947(Tax:10090)	18033(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Differential effects of cyclosporine_A , methylprednisolone , mycophenolate , and rapamycin on CD154 induction and requirement for NFkappaB : implications for tolerance induction .
24500400	0	CD154	15,20	STAT5	57,62	CD154	STAT5	959	6776	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24500400	0	CD154	78,83	STAT5	57,62	CD154	STAT5	959	6776	Gene	Gene	promoter|compound|START_ENTITY binding|nmod|promoter binding|nsubj|expression expression|nmod|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
17485453	0	CD154	18,23	Th1	67,70	CD154	Th1	21947(Tax:10090)	57314(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	In the absence of CD154 , administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma_mansoni .
11672591	0	CD154	59,64	Transforming_growth_factor_beta	0,31	CD154	Transforming growth factor beta	959	7040	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Transforming_growth_factor_beta enhances the expression of CD154 -LRB- CD40L -RRB- and production of tumor_necrosis_factor_alpha by human T lymphocytes .
16741250	0	CD154	0,5	p73	14,17	CD154	p73	959	7161	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	CD154 induces p73 to overcome the resistance to apoptosis of chronic_lymphocytic_leukemia cells lacking functional p53 .
22429743	0	CD155	23,28	CD226	0,5	CD155	CD226	52118(Tax:10090)	225825(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	CD226 interaction with CD155 impacts on retention and negative selection of CD8 positive thymocytes as well as T cell differentiation to follicular helper cells in Peyer 's Patches .
17971293	0	CD155	62,67	CD96	29,33	CD155	CD96	52118(Tax:10090)	84544(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1 .
19056733	0	CD155	22,27	CD96	0,4	CD155	CD96	5817	10225	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains .
15580659	0	CD158c	25,31	KIR3DP1	11,18	CD158c	KIR3DP1	548594	548594	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The silent KIR3DP1 gene -LRB- CD158c -RRB- is transcribed and might encode a secreted receptor in a minority of humans , in whom the KIR3DP1 , KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated .
16904757	0	CD16	15,19	2B4	27,30	CD16	2B4	2214	51744	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ cells|nummod|+ +|compound|END_ENTITY	Persistence of CD16 + / CD56 - / 2B4 + natural killer cells : a highly dysfunctional NK subset expanded in ocular myasthenia_gravis .
25816339	0	CD16	53,57	ADAM17	21,27	CD16	ADAM17	2214	6868	Gene	Gene	Region|nmod|START_ENTITY Region|compound|END_ENTITY	Identification of an ADAM17 Cleavage Region in Human CD16 -LRB- FcyRIII -RRB- and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells .
21454357	0	CD16	20,24	CCR2	25,29	CD16	CD16	2214	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Paradoxical role of CD16 + CCR2 + CCR5 + monocytes in tuberculosis : efficient APC in pleural_effusion but also mark disease severity in blood .
25340088	0	CD16	15,19	CCR2	0,4	CD16	CCR2	2214	729230	Gene	Gene	monocytes|amod|START_ENTITY END_ENTITY|nmod|monocytes	CCR2 on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is a biomarker of HIV-associated_neurocognitive_disorders .
21454357	0	CD16	20,24	CCR5	30,34	CD16	CCR5	2214	1234	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Paradoxical role of CD16 + CCR2 + CCR5 + monocytes in tuberculosis : efficient APC in pleural_effusion but also mark disease severity in blood .
26330348	0	CD16	34,38	CCR5	113,117	CD16	CCR5	2214	1234	Gene	Gene	cells|amod|START_ENTITY retained|nsubjpass|cells retained|nmod|sinusoids sinusoids|nmod|engagement engagement|nmod|pathways pathways|compound|END_ENTITY	Human liver-resident CD56 -LRB- bright -RRB- / CD16 -LRB- neg -RRB- NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways .
23028633	0	CD16	79,83	CCR7	8,12	CD16	CCR7	2214	1236	Gene	Gene	phenotype|compound|START_ENTITY associated|nmod|phenotype NK|ccomp|associated NK|nsubj|Loss Loss|nmod|expression expression|nummod|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
1387727	0	CD16	57,61	CD11b	14,19	CD16	CD11b	2214	3684	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|nmod|antigen antigen|amod|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
10199836	0	CD16	73,77	CD14	65,69	CD16	CD14	2214	929	Gene	Gene	monocyte|nsubj|START_ENTITY expression|parataxis|monocyte expression|nmod|END_ENTITY	Distinct scavenger receptor expression and function in the human CD14 -LRB- + -RRB- / CD16 -LRB- + -RRB- monocyte subset .
10353463	0	CD16	24,28	CD14	18,22	CD16	CD14	2214	929	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD14 + + monocytes , CD14 + / CD16 + subset and soluble CD14 as biological markers of inflammatory systemic diseases and monitoring immunosuppressive therapy .
10879684	0	CD16	63,67	CD14	57,61	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The M-DC8-positive leukocytes are a subpopulation of the CD14 + CD16 + monocytes .
10971526	0	CD16	5,9	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + monocyte subpopulation in Kawasaki_disease .
11167997	0	CD16	73,77	CD14	68,72	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Haemodialysis monocytopenia : differential sequestration kinetics of CD14 + CD16 + and CD14 + + blood monocyte subsets .
11167997	11	CD16	1357,1361	CD14	1352,1356	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	A decline in CD11c surface density paralleled the sequestration of CD14 + CD16 + monocytes .
11513546	0	CD16	152,156	CD14	170,174	CD16	CD14	2214	929	Gene	Gene	characteristics|dep|START_ENTITY analysis|nmod|characteristics END_ENTITY|nsubj|analysis	Comparative analysis of the morphological , cytochemical , immunophenotypical , and functional characteristics of normal human peripheral blood lineage -LRB- - -RRB- / CD16 -LRB- + -RRB- / HLA-DR -LRB- + -RRB- / CD14 -LRB- - / lo -RRB- cells , CD14 -LRB- + -RRB- monocytes , and CD16 -LRB- - -RRB- dendritic cells .
11513546	0	CD16	152,156	CD14	188,192	CD16	CD14	2214	929	Gene	Gene	characteristics|dep|START_ENTITY analysis|nmod|characteristics CD14|nsubj|analysis monocytes|ccomp|CD14 monocytes|nsubj|END_ENTITY	Comparative analysis of the morphological , cytochemical , immunophenotypical , and functional characteristics of normal human peripheral blood lineage -LRB- - -RRB- / CD16 -LRB- + -RRB- / HLA-DR -LRB- + -RRB- / CD14 -LRB- - / lo -RRB- cells , CD14 -LRB- + -RRB- monocytes , and CD16 -LRB- - -RRB- dendritic cells .
11590624	0	CD16	194,198	CD14	167,171	CD16	CD14	2214	929	Gene	Gene	subset|compound|START_ENTITY monocytes|nmod|subset monocytes|nummod|END_ENTITY	Circulating CD33 + large mononuclear cells contain three distinct populations with phenotype of putative antigen-presenting cells including myeloid dendritic cells and CD14 + monocytes with their CD16 + subset .
11704885	0	CD16	22,26	CD14	16,20	CD16	CD14	2214	929	Gene	Gene	monocytes|nummod|START_ENTITY invasion|dep|monocytes invasion|nmod|+ +|compound|END_ENTITY	CNS invasion by CD14 + / CD16 + peripheral blood-derived monocytes in HIV_dementia : perivascular accumulation and reservoir of HIV_infection .
11907116	0	CD16	25,29	CD14	20,24	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The proinflammatory CD14 + CD16 + DR + + monocytes are a major source of TNF .
11958435	0	CD16	10,14	CD14	4,8	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The CD14 + CD16 + monocyte subset in rheumatoid_arthritis and systemic_lupus_erythematosus .
11981819	0	CD16	9,13	CD14	4,8	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The CD14 + CD16 + monocytes in erysipelas are expanded and show reduced cytokine production .
12028567	0	CD16	5,9	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + monocytes in the course of sepsis in neonates and small children : monitoring and functional studies .
12384915	0	CD16	6,10	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	monocytes|nummod|START_ENTITY +|appos|monocytes +|compound|END_ENTITY	CD14 + , CD16 + blood monocytes and joint_inflammation in rheumatoid_arthritis .
12832440	0	CD16	60,64	CD14	55,59	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mechanism of glucocorticoid-induced depletion of human CD14 + CD16 + monocytes .
12847232	0	CD16	39,43	CD14	34,38	CD16	CD14	2214	929	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	P-selectin enhances generation of CD14 + CD16 + dendritic-like cells and inhibits macrophage maturation from human peripheral blood monocytes .
12928539	0	CD16	18,22	CD14	12,16	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Circulating CD14 + CD16 + monocytes are expanded in sarcoidosis patients .
14576364	0	CD16	80,84	CD14	75,79	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Autologous stem-cell transplantation restores the functional properties of CD14 + CD16 + monocytes in patients with myeloma and lymphoma .
15269840	0	CD16	5,9	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + monocytes in coronary_artery_disease and their relationship to serum TNF-alpha levels .
15308326	0	CD16	28,32	CD14	22,26	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY monocyte|nsubj|+ response|parataxis|monocyte response|nmod|+ +|compound|END_ENTITY	Antitumor response of CD14 + / CD16 + monocyte subpopulation .
15325277	0	CD16	108,112	CD14	103,107	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
15373966	0	CD16	72,76	CD14	78,82	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16 + CD14 + monocytes in patients with septic_shock .
16825330	0	CD16	59,63	CD14	54,58	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	On-line hemodiafiltration reduces the proinflammatory CD14 + CD16 + monocyte-derived dendritic cells : A prospective , crossover study .
16928619	0	CD16	76,80	CD14	71,75	CD16	CD14	2214	929	Gene	Gene	monocyte|compound|START_ENTITY monocyte|compound|END_ENTITY	Biocompatibility study based on differential sequestration kinetics of CD14 + CD16 + blood monocyte subsets with different dialyzers .
17135573	0	CD16	10,14	CD14	4,8	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The CD14 + CD16 + blood monocytes : their role in infection and inflammation .
1715711	0	CD16	13,17	CD14	7,11	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Small -LRB- CD14 + / CD16 + -RRB- monocytes and regular monocytes in human blood .
17619880	0	CD16	35,39	CD14	27,31	CD16	CD14	2214	929	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|compound|END_ENTITY	Selective expansion of the CD14 -LRB- + -RRB- / CD16 -LRB- bright -RRB- subpopulation of circulating monocytes in patients with hemophagocytic_syndrome .
18021284	0	CD16	21,25	CD14	16,20	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Proinflammatory CD14 + CD16 + monocytes are associated with subclinical atherosclerosis in renal transplant patients .
18177452	0	CD16	54,58	CD14	49,53	CD16	CD14	2214	929	Gene	Gene	DR|compound|START_ENTITY DR|compound|END_ENTITY	Adsorptive depletion of elevated proinflammatory CD14 + CD16 + DR + + monocytes in patients with inflammatory_bowel_disease .
18664531	0	CD16	57,61	CD14	52,56	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Exercise training-induced lowering of inflammatory -LRB- CD14 + CD16 + -RRB- monocytes : a role in the anti-inflammatory influence of exercise ?
18952503	0	CD16	30,34	CD14	24,28	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced frequencies of CD14 + + CD16 + , but not CD14 + CD16 + , peripheral blood monocytes in severe asthmatic patients .
18952503	0	CD16	50,54	CD14	45,49	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced frequencies of CD14 + + CD16 + , but not CD14 + CD16 + , peripheral blood monocytes in severe asthmatic patients .
19001052	0	CD16	102,106	CD14	96,100	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Different functions of monocyte subsets in familial_hypercholesterolemia : potential function of CD14 + CD16 + monocytes in detoxification of oxidized LDL .
19950429	0	CD16	10,14	CD14	30,34	CD16	CD14	2214	929	Gene	Gene	START_ENTITY|nmod|CD16 CD16|compound|END_ENTITY	CD14 -LRB- high -RRB- CD16 -LRB- + -RRB- rather than CD14 -LRB- low -RRB- CD16 -LRB- + -RRB- monocytes correlate with disease progression in chronic HIV-infected patients .
19950429	0	CD16	39,43	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	CD16|nmod|START_ENTITY CD16|compound|END_ENTITY	CD14 -LRB- high -RRB- CD16 -LRB- + -RRB- rather than CD14 -LRB- low -RRB- CD16 -LRB- + -RRB- monocytes correlate with disease progression in chronic HIV-infected patients .
20231419	0	CD16	51,55	CD14	45,49	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The levels of CD16/Fc _ gamma_receptor_IIIA on CD14 + CD16 + monocytes are higher in children with severe Plasmodium_falciparum anemia than in children with cerebral or uncomplicated malaria .
20580035	0	CD16	150,154	CD14	145,149	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Adding exercise to rosuvastatin treatment : influence on C-reactive_protein , monocyte toll-like_receptor_4 expression , and inflammatory monocyte -LRB- CD14 + CD16 + -RRB- population .
20586272	0	CD16	22,26	CD14	17,21	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	-LSB- CD14 + + CD16 - and CD14 + CD16 + human monocytes adhesion to endothelial cells -RSB- .
20662093	0	CD16	81,85	CD14	76,80	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Standardized single-platform assay for human monocyte subpopulations : Lower CD14 + CD16 + + monocytes in females .
20943670	0	CD16	6,10	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + + CD16 + monocytes and cardiovascular outcome in patients with chronic_kidney_disease .
21191073	0	CD16	15,19	CD14	10,14	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Senescent CD14 + CD16 + monocytes exhibit proinflammatory and proatherosclerotic activity .
21303362	0	CD16	55,59	CD14	49,53	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Elevated blood levels of inflammatory monocytes -LRB- CD14 + CD16 + -RRB- in patients with complex_regional_pain_syndrome .
21368871	0	CD16	120,124	CD14	4,8	CD16	CD14	2214	929	Gene	Gene	apoptosis|nmod|START_ENTITY susceptible|nmod|apoptosis subset|amod|susceptible monocyte|ccomp|subset monocyte|nsubj|CD16 CD16|compound|END_ENTITY	The CD14 -LRB- + / low -RRB- CD16 -LRB- + -RRB- monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14 -LRB- + -RRB- CD16 -LRB- - -RRB- subset .
21368871	0	CD16	15,19	CD14	113,117	CD16	CD14	2214	929	Gene	Gene	monocyte|nsubj|START_ENTITY monocyte|ccomp|subset subset|amod|susceptible susceptible|nmod|apoptosis apoptosis|nmod|CD16 CD16|compound|END_ENTITY	The CD14 -LRB- + / low -RRB- CD16 -LRB- + -RRB- monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14 -LRB- + -RRB- CD16 -LRB- - -RRB- subset .
21531464	0	CD16	38,42	CD14	45,49	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The response to TLR ligation of human CD16 CD14 monocytes is weakly modulated as a consequence of persistent infection with the hepatitis_C_virus .
21544980	0	CD16	23,27	CD14	18,22	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Subpopulation of CD14 + CD16 + monocytes in the children with acute_lymphoblastic_leukemia treated with filgrastim -RSB- .
21625090	0	CD16	5,9	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	CD14 + CD16 + monocytes from chronic kidney_disease patients exhibit increased adhesion ability to endothelial cells .
21695694	0	CD16	75,79	CD14	67,71	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	The classical CD14 CD16 monocytes , but not the patrolling CD14 CD16 monocytes , promote Th17 responses to Candida_albicans .
21799175	0	CD16	22,26	CD14	17,21	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14dimCD16 + and CD14 + CD16 + monocytes in obesity and during weight_loss : relationships with fat mass and subclinical atherosclerosis .
21803849	0	CD16	29,33	CD14	23,27	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	SuperSAGE evidence for CD14 + + CD16 + monocytes as a third monocyte subset .
21838603	0	CD16	115,119	CD14	56,60	CD16	CD14	2214	929	Gene	Gene	CD64|nmod|START_ENTITY CD64|nsubj|differentiation differentiation|nmod|CD16 CD16|compound|END_ENTITY	Mesenchymal stromal cells impair the differentiation of CD14 -LRB- + + -RRB- CD16 -LRB- - -RRB- CD64 -LRB- + -RRB- classical monocytes into CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD64 -LRB- + + -RRB- activate monocytes .
21838603	0	CD16	65,69	CD14	106,110	CD16	CD14	2214	929	Gene	Gene	differentiation|nmod|START_ENTITY CD64|nsubj|differentiation CD64|nmod|CD16 CD16|compound|END_ENTITY	Mesenchymal stromal cells impair the differentiation of CD14 -LRB- + + -RRB- CD16 -LRB- - -RRB- CD64 -LRB- + -RRB- classical monocytes into CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD64 -LRB- + + -RRB- activate monocytes .
21847775	0	CD16	21,25	CD14	16,20	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Proinflammatory CD14 + CD16 + monocytes are associated with microinflammation in patients with type_2_diabetes_mellitus and diabetic_nephropathy_uremia .
21936856	0	CD16	30,34	CD14	24,28	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Possible involvement of CD14 + CD16 + monocyte lineage cells in the epidermal_damage of Stevens-Johnson_syndrome and toxic_epidermal_necrolysis .
22006178	0	CD16	17,21	CD14	4,8	CD16	CD14	2214	929	Gene	Gene	subset|amod|START_ENTITY subset|compound|END_ENTITY	The CD14 -LRB- bright -RRB- CD16 + monocyte subset is expanded in rheumatoid_arthritis and promotes expansion of the Th17 cell population .
22247233	0	CD16	73,77	CD14	68,72	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Losartan prevents the development of the pro-inflammatory monocytes CD14 + CD16 + in haemodialysis patients .
22484242	0	CD16	18,22	CD14	13,17	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of CD14 + CD16 + monocytes producing TNF-a in complication-free_diabetes_type_1 juvenile onset patients .
22961048	0	CD16	67,71	CD14	62,66	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Selective expansion of pro-inflammatory chemokine CCL2-loaded CD14 + CD16 + monocytes subset in HIV-infected therapy na ve individuals .
23046368	0	CD16	31,35	CD14	24,28	CD16	CD14	2214	929	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Adsorptive depletion of CD14 CD16 proinflammatory monocyte phenotype in patients with generalized pustular_psoriasis : clinical efficacy and effects on cytokines .
23240665	0	CD16	6,10	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + + CD16 + monocytes in patients with acute ischaemic heart_failure .
23595503	0	CD16	29,33	CD14	23,27	CD16	CD14	2214	929	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Reduced frequency of a CD14 + CD16 + monocyte subset with high Toll-like_receptor_4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns .
24001047	0	CD16	50,54	CD14	45,49	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Comparison of the proportion of non-classic -LRB- CD14 + CD16 + -RRB- monocytes/macrophages in peripheral blood and gingiva of healthy individuals and patients with chronic_periodontitis .
24182800	0	CD16	25,29	CD14	20,24	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation between CD14 + CD16 + + monocytes in peripheral blood and hypertriglyceridemia after allograft renal transplantation .
24432835	0	CD16	125,129	CD14	120,124	CD16	CD14	720006(Tax:9544)	697482(Tax:9544)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Glucocorticoid treatment at moderate doses of SIVmac251-infected rhesus_macaques decreases the frequency of circulating CD14 + CD16 + + monocytes but does not alter the tissue virus reservoir .
24499053	0	CD16	5,9	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + and CD14 + CD163 + monocyte subpopulations in kidney allograft transplantation .
24650765	6	CD16	1079,1083	CD14	1070,1074	CD16	CD14	2214	929	Gene	Gene	population|amod|START_ENTITY population|amod|END_ENTITY	In both normal and SLE patients , the CD14 CD16 subpopulation of monocytes expressed the highest levels of Mer , with somewhat lower levels on the CD14 -LRB- int -RRB- CD16 population .
24661393	0	CD16	8,12	CD14	38,42	CD16	CD14	2214	929	Gene	Gene	monocytes|nsubj|START_ENTITY monocytes|ccomp|marker marker|advcl|CD51/61 CD51/61|compound|END_ENTITY	CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes rather than CD14 -LRB- + -RRB- CD51/61 -LRB- + -RRB- monocytes are a potential cytological marker of circulating osteoclast precursors in multiple_myeloma .
24832193	0	CD16	79,83	CD14	74,78	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Resistance exercise training-induced decrease in circulating inflammatory CD14 + CD16 + monocyte percentage without weight_loss in older adults .
24995492	0	CD16	56,60	CD14	50,54	CD16	CD14	2214	929	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Trophoblast induces monocyte differentiation into CD14 + / CD16 + macrophages .
25060791	0	CD16	83,87	CD14	77,81	CD16	CD14	2214	929	Gene	Gene	counts|compound|START_ENTITY counts|compound|END_ENTITY	Lower Apo_A-I_and_lower_HDL-C levels are associated with higher intermediate CD14 + + CD16 + monocyte counts that predict cardiovascular_events in chronic_kidney_disease .
25134759	0	CD16	98,102	CD14	91,95	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|nummod|END_ENTITY	Bezafibrate , a peroxisome proliferator-activated receptor a agonist , decreases circulating CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes in patients with type 2 diabetes .
25168844	0	CD16	28,32	CD14	23,27	CD16	CD14	2214	929	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
25168844	0	CD16	28,32	CD14	48,52	CD16	CD14	2214	929	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|nmod|Cd16 Cd16|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
25172544	0	CD16	69,73	CD14	63,67	CD16	CD14	2214	929	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Human endotoxin tolerance is associated with enrichment of the CD14 + CD16 + monocyte subset .
25233271	0	CD16	9,13	CD14	4,8	CD16	CD14	2214	929	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	The CD14 + CD16 + inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium_vivax malaria .
25340088	0	CD16	15,19	CD14	8,12	CD16	CD14	2214	929	Gene	Gene	monocytes|amod|START_ENTITY monocytes|amod|END_ENTITY	CCR2 on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is a biomarker of HIV-associated_neurocognitive_disorders .
25420915	0	CD16	85,89	CD14	80,84	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14 + CD16 + monocytes in HIV-infected individuals .
25850575	0	CD16	9,13	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	Monocytes|amod|START_ENTITY Monocytes|amod|END_ENTITY	CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- HLA-DR -LRB- + -RRB- Monocytes in Peripheral Blood are Quantitatively Correlated with the Severity of Pre-eclampsia .
25911752	0	CD16	6,10	CD14	0,4	CD16	CD14	2214	929	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	CD14 + + CD16 + Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses .
26550139	0	CD16	20,24	CD14	13,17	CD16	CD14	2214	929	Gene	Gene	monocytes|amod|START_ENTITY monocytes|amod|END_ENTITY	Expansion of CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocytes is related to acute_leukemia .
26578679	0	CD16	105,109	CD14	99,103	CD16	CD14	2214	929	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14 + CD16 + CD64high CD32low Inflammatory Monocytes from Malaria Patients .
26658828	0	CD16	68,72	CD14	62,66	CD16	CD14	2214	929	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	Increased Protease-Activated_Receptor-2 -LRB- PAR-2 -RRB- Expression on CD14 + + CD16 + Peripheral Blood Monocytes of Patients with Severe Asthma .
26747736	0	CD16	30,34	CD14	24,28	CD16	CD14	2214	929	Gene	Gene	+|nsubj|START_ENTITY Analysis|parataxis|+ Analysis|acl|circulating circulating|dobj|+ +|compound|END_ENTITY	Analysis of circulating CD14 + / CD16 + monocyte-derived macrophages -LRB- MDMs -RRB- in the peripheral blood of patients with oral_squamous_cell_carcinoma .
26826137	0	CD16	31,35	CD14	25,29	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|compound|END_ENTITY	Circulating intermediate CD14 + + CD16 + monocytes are increased in patients with atrial_fibrillation and reflect the functional remodelling of the left atrium .
7543538	0	CD16	42,46	CD14	21,25	CD16	CD14	2214	929	Gene	Gene	found|nmod|START_ENTITY found|nsubjpass|receptors receptors|appos|END_ENTITY	Endotoxin receptors -LRB- CD14 -RRB- are found with CD16 -LRB- Fc_gamma_RIII -RRB- in an intracellular compartment of neutrophils that contains alkaline phosphatase .
7690321	0	CD16	26,30	CD14	20,24	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY exhibits|nsubj|monocytes subset|parataxis|exhibits subset|nmod|+ +|compound|END_ENTITY	The novel subset of CD14 + / CD16 + blood monocytes exhibits features of tissue macrophages .
7693040	0	CD16	26,30	CD14	20,24	CD16	CD14	2214	929	Gene	Gene	monocytes|compound|START_ENTITY expanded|nsubjpass|monocytes subset|parataxis|expanded subset|nmod|+ +|compound|END_ENTITY	The novel subset of CD14 + / CD16 + blood monocytes is expanded in sepsis patients .
9249916	0	CD16	51,55	CD14	46,50	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cytokine production precedes the expansion of CD14 + CD16 + monocytes in human sepsis : a case report of a patient with self-induced septicemia .
9596748	0	CD16	15,19	CD14	9,13	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expanded CD14 + CD16 + monocyte subpopulation in patients with acute and chronic_infections undergoing hemodialysis .
9649222	0	CD16	29,33	CD14	23,27	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Selective depletion of CD14 + CD16 + monocytes by glucocorticoid therapy .
9675608	0	CD16	18,22	CD14	13,17	CD16	CD14	2214	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of CD14 + CD16 + monocytes in critically ill cardiac surgery patients .
16078278	0	CD16	14,18	CD16	21,25	CD16	CD16	2214	2214	Gene	Gene	START_ENTITY|dep|cells cells|dep|END_ENTITY	Human resting CD16 - , CD16 + and IL-2 - , IL-12 - , IL-15 - or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine , lysophosphatidylcholine and platelet-activating factor .
16078278	0	CD16	21,25	CD16	14,18	CD16	CD16	2214	2214	Gene	Gene	cells|dep|START_ENTITY END_ENTITY|dep|cells	Human resting CD16 - , CD16 + and IL-2 - , IL-12 - , IL-15 - or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine , lysophosphatidylcholine and platelet-activating factor .
2150319	0	CD16	0,4	CD16	92,96	CD16	CD16	2214	2214	Gene	Gene	cells|compound|START_ENTITY decrease|nsubj|cells decrease|nmod|depletion depletion|nmod|CD3 CD3|compound|END_ENTITY	CD16 + NK cells decrease in all stages of HIV_infection through a selective depletion of the CD16 + CD8 + CD3 - subset .
2150319	0	CD16	92,96	CD16	0,4	CD16	CD16	2214	2214	Gene	Gene	CD3|compound|START_ENTITY depletion|nmod|CD3 decrease|nmod|depletion decrease|nsubj|cells cells|compound|END_ENTITY	CD16 + NK cells decrease in all stages of HIV_infection through a selective depletion of the CD16 + CD8 + CD3 - subset .
11970990	0	CD16	78,82	CD2	129,132	CD16	CD2	2214	914	Gene	Gene	signaling|nummod|START_ENTITY signaling|nmod|cells cells|amod|END_ENTITY	Alefacept , an immunomodulatory recombinant LFA-3 / IgG1 fusion protein , induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2 -LRB- + -RRB- cells .
2346908	0	CD16	120,124	CD2	96,99	CD16	CD2	2214	914	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
8104886	0	CD16	12,16	CD2	68,71	CD16	CD2	2214	914	Gene	Gene	cells|nummod|START_ENTITY Adhesion|nmod|cells mediated|nsubjpass|Adhesion mediated|nmod|receptors receptors|compound|END_ENTITY	Adhesion of CD16 + K cells to antibody-coated targets is mediated by CD2 and CD18 receptors .
26142193	0	CD16	34,38	CD31	8,12	CD16	CD31	2214	5175	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduced CD31 expression on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocyte subset in acute_coronary_syndromes .
7517211	0	CD16	23,27	CD33	9,13	CD16	CD33	2214	945	Gene	Gene	-|appos|START_ENTITY -|appos|+ +|compound|END_ENTITY	HLA-DR - , CD33 + , CD56 + , CD16 - myeloid/natural killer cell acute_leukemia : a previously unrecognized form of acute_leukemia potentially misdiagnosed as French-American-British acute_myeloid_leukemia-M3 .
10651077	0	CD16	14,18	CD4	10,13	CD16	CD4	2214	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased CD4 + CD16 + and CD4 + CD56 + T cell subsets in Beh et 's disease .
11340249	0	CD16	17,21	CD4	13,16	CD16	CD4	2214	920	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Expansion of CD4 + CD16 + blood monocytes in patients with chronic_renal_failure undergoing dialysis : possible involvement of macrophage_colony-stimulating_factor .
11717198	0	CD16	0,4	CD4	125,128	CD16	CD4	2214	920	Gene	Gene	+|compound|START_ENTITY +|parataxis|differentiate differentiate|nmod|cells cells|amod|vitro vitro|nmod|abilities abilities|acl|stimulate stimulate|dobj|T T|compound|END_ENTITY	CD16 + and CD16 - human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4 + T cells .
1387727	0	CD16	57,61	CD4	45,48	CD16	CD4	2214	920	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
14616964	0	CD16	39,43	CD4	112,115	CD16	CD4	2214	920	Gene	Gene	T-cell|compound|START_ENTITY analysis|nmod|T-cell analysis|dep|association association|nmod|phenotypes phenotypes|nummod|END_ENTITY	TCR Vbeta repertoire analysis in CD56 + CD16 -LRB- dim / - -RRB- T-cell large granular lymphocyte leukaemia : association with CD4 single and CD4/CD8 double positive phenotypes .
1828937	0	CD16	97,101	CD4	40,43	CD16	CD4	2214	920	Gene	Gene	CD57|appos|START_ENTITY lack|dobj|CD57 cells|acl:relcl|lack cells|nmod|skin_lesions skin_lesions|nmod|mycosis_fungoides mycosis_fungoides|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
21227406	0	CD16	43,47	CD4	105,108	CD16	CD4	2214	920	Gene	Gene	expression|nmod|START_ENTITY maintains|dobj|expression maintains|nmod|monocytes monocytes|nmod|production production|nmod|cells cells|amod|IL-10 IL-10|nmod|T T|compound|END_ENTITY	Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human na ve CD4 + T cells .
2346908	0	CD16	120,124	CD4	108,111	CD16	CD4	2214	920	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|appos|- -|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
11252817	0	CD16	44,48	CD56	66,70	CD16	CD56	2214	4684	Gene	Gene	CD56|compound|START_ENTITY capabilities|nmod|CD56 capabilities|dep|+ +|compound|END_ENTITY	Proliferative and cytotoxic capabilities of CD16 + CD56 - and CD16 + / - CD56 + natural killer cells .
11252817	0	CD16	59,63	CD56	49,53	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Proliferative and cytotoxic capabilities of CD16 + CD56 - and CD16 + / - CD56 + natural killer cells .
11252817	0	CD16	59,63	CD56	66,70	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY CD56|dep|+ capabilities|nmod|CD56 capabilities|dep|+ +|compound|END_ENTITY	Proliferative and cytotoxic capabilities of CD16 + CD56 - and CD16 + / - CD56 + natural killer cells .
11883210	0	CD16	86,90	CD56	92,96	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY percentage|nmod|+ immunization|nmod|percentage lymphocytes|acl|immunization influence|nmod|lymphocytes -LSB-|dobj|influence cells|dep|-LSB- cells|nummod|END_ENTITY	-LSB- The influence of paternal lymphocytes immunization on percentage of peripheral blood CD16 + / CD56 + cells in women with primary recurrent spontaneous_abortion -RSB- .
12076260	0	CD16	44,48	CD56	61,65	CD16	CD56	2214	4684	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Uncoupling activation-induced modulation of CD16 and CD69 in CD56 + cells during AIDS .
12412742	0	CD16	52,56	CD56	66,70	CD16	CD56	2214	4684	Gene	Gene	synthesis|nmod|START_ENTITY immunoglobulin|acl|synthesis Suppression|nmod|immunoglobulin Suppression|dep|+ +|compound|END_ENTITY	Suppression of in vitro immunoglobulin synthesis by CD16 -LRB- Leu11a -RRB- + CD56 -LRB- NKH1 , Leu19 -RRB- + non-T lineage NK cells ; lack of suppression of cells from immunodeficient patients .
1375847	0	CD16	0,4	CD56	6,10	CD16	CD56	2214	4684	Gene	Gene	START_ENTITY|dep|cells cells|nummod|END_ENTITY	CD16 - CD56 + natural killer cells after bone marrow transplantation .
14505740	0	CD16	56,60	CD56	50,54	CD16	CD56	2214	4684	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Fraction of the peripheral blood concentration of CD56 + / CD16 - / CD3 - cells in total natural killer cells as an indication of fertility and infertility .
14616964	0	CD16	39,43	CD56	33,37	CD16	CD56	2214	4684	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	TCR Vbeta repertoire analysis in CD56 + CD16 -LRB- dim / - -RRB- T-cell large granular lymphocyte leukaemia : association with CD4 single and CD4/CD8 double positive phenotypes .
16904757	0	CD16	15,19	CD56	21,25	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Persistence of CD16 + / CD56 - / 2B4 + natural killer cells : a highly dysfunctional NK subset expanded in ocular myasthenia_gravis .
1692496	0	CD16	34,38	CD56	19,23	CD16	CD56	2214	4684	Gene	Gene	cells|nummod|START_ENTITY populations|dep|cells populations|nmod|+ +|compound|END_ENTITY	Two populations of CD56 -LRB- Leu-19 -RRB- + / CD16 + cells in bone marrow transplant recipients .
17878347	0	CD16	160,164	CD56	166,170	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY subset|nummod|+ subset|compound|END_ENTITY	The CD16 - CD56 -LRB- bright -RRB- NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16 + CD56 -LRB- dim -RRB- subset .
18203207	0	CD16	94,98	CD56	82,86	CD16	CD56	2214	4684	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural killer cells infiltrating human nonsmall-cell_lung_cancer are enriched in CD56 bright CD16 -LRB- - -RRB- cells and display an impaired capability to kill tumor cells .
1828937	0	CD16	97,101	CD56	103,107	CD16	CD56	2214	4684	Gene	Gene	CD57|appos|START_ENTITY CD57|appos|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
20543659	0	CD16	86,90	CD56	80,84	CD16	CD56	2214	4684	Gene	Gene	+|nsubj|START_ENTITY contribute|parataxis|+ contribute|nmod|expansion expansion|nmod|END_ENTITY	Phenotypically and functionally distinct subsets contribute to the expansion of CD56 - / CD16 + natural killer cells in HIV_infection .
20553754	0	CD16	0,4	CD56	51,55	CD16	CD56	2214	4684	Gene	Gene	cross-linking|compound|START_ENTITY induces|nsubj|cross-linking induces|dobj|expression expression|nmod|END_ENTITY	CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells .
20664990	0	CD16	27,31	CD56	32,36	CD16	CD56	2214	4684	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural killer-like T CD3 + / CD16 + CD56 + cells in chronic_lymphocytic_leukemia : intracellular cytokine expression and relationship with clinical outcome .
20734041	0	CD16	68,72	CD56	60,64	CD16	CD56	2214	4684	Gene	Gene	NK|nsubj|START_ENTITY Identification|parataxis|NK Identification|nmod|tumor tumor|acl|infiltrating infiltrating|dobj|+ +|compound|END_ENTITY	Identification and characterization of a tumor infiltrating CD56 -LRB- + -RRB- / CD16 -LRB- - -RRB- NK cell subset with specificity for pancreatic_and_prostate_cancer cell lines .
21187373	0	CD16	81,85	CD56	72,76	CD16	CD56	2214	4684	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Revisiting human natural killer cell subset function revealed cytolytic CD56 -LRB- dim -RRB- CD16 + NK cells as rapid producers of abundant IFN-gamma on activation .
21457956	0	CD16	79,83	CD56	74,78	CD16	CD56	2214	4684	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Maturation of human ovarian follicles is accompanied by a decrease in the CD56 + CD16 + natural killer cell population .
21526506	0	CD16	5,9	CD56	10,14	CD16	CD56	2214	4684	Gene	Gene	numbers|compound|START_ENTITY numbers|compound|END_ENTITY	CD3 + / CD16 + CD56 + cell numbers in peripheral blood are correlated with higher_tumor burden in patients with diffuse_large_B-cell_lymphoma .
21996223	0	CD16	33,37	CD56	38,42	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Lymphocyte subtypes CD3 + , CD19 + , CD16 + CD56 + , CD4 + , CD8 + , and CD3 + HLA-DR + in peripheral blood obtained from patients after thoracic organ transplantation .
23028633	0	CD16	79,83	CD56	27,31	CD16	CD56	2214	4684	Gene	Gene	phenotype|compound|START_ENTITY associated|nmod|phenotype NK|ccomp|associated NK|nsubj|Loss Loss|nmod|expression expression|nmod|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
23028633	0	CD16	79,83	CD56	70,74	CD16	CD56	2214	4684	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
24225017	0	CD16	30,34	CD56	17,21	CD16	CD56	2214	4684	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Mature cytotoxic CD56 -LRB- bright -RRB- / CD16 -LRB- + -RRB- natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma .
26330348	0	CD16	34,38	CD56	21,25	CD16	CD56	2214	4684	Gene	Gene	cells|amod|START_ENTITY retained|nsubjpass|cells Human|parataxis|retained Human|dep|END_ENTITY	Human liver-resident CD56 -LRB- bright -RRB- / CD16 -LRB- neg -RRB- NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways .
27027597	0	CD16	36,40	CD56	0,4	CD16	CD56	2214	4684	Gene	Gene	START_ENTITY|nsubj|CD16 CD16|compound|END_ENTITY	CD56 -LRB- dim -RRB- CD16 -LRB- high -RRB- and CD56 -LRB- bright -RRB- CD16 -LRB- - -RRB- cell percentages associated with maximum knee extensor strength and incidence of death in elderly .
7517211	0	CD16	23,27	CD56	16,20	CD16	CD56	2214	4684	Gene	Gene	-|appos|START_ENTITY -|appos|+ +|compound|END_ENTITY	HLA-DR - , CD33 + , CD56 + , CD16 - myeloid/natural killer cell acute_leukemia : a previously unrecognized form of acute_leukemia potentially misdiagnosed as French-American-British acute_myeloid_leukemia-M3 .
7552495	0	CD16	99,103	CD56	104,108	CD16	CD56	2214	4684	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural killer cell immunodeficiency in HIV_disease is manifest by profoundly decreased numbers of CD16 + CD56 + cells and expansion of a population of CD16dimCD56 - cells with low lytic activity .
7587727	0	CD16	39,43	CD56	45,49	CD16	CD56	2214	4684	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	Evidence of a selective depletion of a CD16 + CD56 + CD8 + natural killer cell subset during HIV_infection .
7691868	0	CD16	57,61	CD56	43,47	CD16	CD56	2214	4684	Gene	Gene	CD3|nummod|START_ENTITY +|appos|CD3 +|compound|END_ENTITY	Distribution of cell adhesion molecules on CD56 + + , CD3 - , CD16 - large granular lymphocytes and endothelial cells in first-trimester human decidua .
8526995	0	CD16	40,44	CD56	34,38	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Up-regulated expression of CD56 + , CD56 + / CD16 + , and CD19 + cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses .
8920872	0	CD16	46,50	CD56	40,44	CD16	CD56	2214	4684	Gene	Gene	+|dep|START_ENTITY +|dep|END_ENTITY	Definition of a natural killer NKR-P1A + / CD56 - / CD16 - functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12 .
8993118	0	CD16	6,10	CD56	13,17	CD16	CD56	2214	4684	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|appos|cells cells|nummod|END_ENTITY	CD3 + , CD16 + , CD56 + cells : a novel subset of T lymphocytes from patients with Balkanic_nephropathy .
9009088	0	CD16	61,65	CD56	68,72	CD56	CD57	4684	27087	Gene	Gene	+|dep|START_ENTITY growth|amod|+ growth|appos|+ +|compound|END_ENTITY	Autocrine IL-2-dependent growth of a newly established CD3 + , CD16 - , CD56 + , CD57 + , J -LRB- H -RRB- - , TCRbeta - , TCRgamma - _ leukemia cell line -LRB- NOI-90 -RRB- .
11100948	0	CD16	116,120	CD57	111,115	CD16	CD57	2214	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effects of occupational metallic mercury vapour exposure on suppressor-inducer -LRB- CD4 + CD45RA + -RRB- T lymphocytes and CD57 + CD16 + natural killer cells .
9009088	0	CD16	61,65	CD57	75,79	CD56	CD57	4684	27087	Gene	Gene	+|dep|START_ENTITY growth|amod|+ growth|appos|+ +|compound|END_ENTITY	Autocrine IL-2-dependent growth of a newly established CD3 + , CD16 - , CD56 + , CD57 + , J -LRB- H -RRB- - , TCRbeta - , TCRgamma - _ leukemia cell line -LRB- NOI-90 -RRB- .
1835413	0	CD16	86,90	CD67	69,73	CD16	CD67	2214	1088	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Intracellular localization of glycosyl-phosphatidylinositol-anchored CD67 and FcRIII -LRB- CD16 -RRB- in affected neutrophil granulocytes of patients with paroxysmal_nocturnal_hemoglobinuria .
1387727	0	CD16	57,61	CD8	51,54	CD16	CD8	2214	925	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
1828937	0	CD16	97,101	CD8	5,8	CD16	CD8	2214	925	Gene	Gene	CD57|appos|START_ENTITY lack|dobj|CD57 cells|acl:relcl|lack cells|nsubj|cells cells|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18768879	0	CD16	37,41	CD8	53,56	CD16	CD8	2214	925	Gene	Gene	+|compound|START_ENTITY +|appos|+ numbers|nmod|+ effector|nsubj|numbers effector|dobj|cells cells|compound|END_ENTITY	Elevated numbers of Fc gamma RIIIA + -LRB- CD16 + -RRB- effector CD8 T cells with NK cell-like function in chronic_hepatitis_C_virus_infection .
2150319	0	CD16	0,4	CD8	97,100	CD16	CD8	2214	925	Gene	Gene	cells|compound|START_ENTITY decrease|nsubj|cells decrease|nmod|depletion depletion|nmod|CD3 CD3|compound|END_ENTITY	CD16 + NK cells decrease in all stages of HIV_infection through a selective depletion of the CD16 + CD8 + CD3 - subset .
2150319	0	CD16	92,96	CD8	97,100	CD16	CD8	2214	925	Gene	Gene	CD3|compound|START_ENTITY CD3|compound|END_ENTITY	CD16 + NK cells decrease in all stages of HIV_infection through a selective depletion of the CD16 + CD8 + CD3 - subset .
2346908	0	CD16	120,124	CD8	114,117	CD16	CD8	2214	925	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|appos|- -|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
2525425	2	CD16	73,77	CD8	69,72	CD16	CD8	2214	925	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Frequency and clonal specificity of CD8 + CD16 - -LRB- Leu2 + Leu11 - -RRB- and CD16 + CD3 - -LRB- Leu11 + Leu4 - -RRB- cytotoxic lymphocyte precursors activated by alloantigen or K562 stimulator cells .
3259141	0	CD16	41,45	CD8	35,38	CD16	CD8	2214	925	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Selective depletion of low-density CD8 + , CD16 + lymphocytes during HIV_infection .
8181530	0	CD16	91,95	CD8	75,78	CD16	CD8	2214	925	Gene	Gene	cells|nummod|START_ENTITY +|nmod|cells +|nsubj|Inhibition Inhibition|nmod|proliferation proliferation|nmod|END_ENTITY	Inhibition of anti-GD3-ganglioside antibody-induced proliferation of human CD8 + T cells by CD16 + natural killer cells .
25830914	0	CD16	105,109	CX3CR1	110,116	CD16	CX3CR1	2214	1524	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	Transcriptome Analysis in Patients with Chronic_Kidney_Disease on Hemodialysis Disclosing a Key Role for CD16 + CX3CR1 + Monocytes .
25168844	0	CD16	28,32	Cd16	54,58	CD16	Cd16	2214	2214	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|nmod|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
7692930	0	CD16	29,33	Fc_gamma_R-III	13,27	CD16	Fc gamma R-III	2214	2214	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of Fc_gamma_R-III -LRB- CD16 -RRB- expression on neutrophils affected by paroxysmal_nocturnal_haemoglobinuria by administration of granulocyte colony-stimulating factor .
1653804	0	CD16	45,49	Fc_gamma_RIII	30,43	CD16	Fc gamma RIII	2214	2214	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	IL-4 antagonizes induction of Fc_gamma_RIII -LRB- CD16 -RRB- expression by transforming_growth_factor-beta on human monocytes .
1825220	0	CD16	27,31	Fc_gamma_RIII	12,25	CD16	Fc gamma RIII	2214	2214	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of Fc_gamma_RIII -LRB- CD16 -RRB- membrane expression and association with CD3_zeta and Fc_epsilon_RI-gamma by site-directed mutation .
1826887	0	CD16	46,50	Fc_gamma_RIII	31,44	CD16	Fc gamma RIII	2214	2214	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Platelet-induced expression of Fc_gamma_RIII -LRB- CD16 -RRB- on human monocytes .
7512596	0	CD16	51,55	Fc_gamma_RIII	36,49	CD16	Fc gamma RIII	2214	2214	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Membrane-proximal Ig-like domain of Fc_gamma_RIII -LRB- CD16 -RRB- contains residues critical for ligand binding .
8027553	0	CD16	55,59	Fc_gamma_RIII	61,74	CD16	Fc gamma RIII	2214	2214	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Neutrophil apoptosis is associated with a reduction in CD16 -LRB- Fc_gamma_RIII -RRB- expression .
8570089	0	CD16	139,143	Fc_gamma_RIII	115,128	CD16	Fc gamma RIII	2214	2214	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Detection by 4-parameter microscopic imaging and increase of rare mononuclear blood leukocyte types expressing the Fc_gamma_RIII receptor -LRB- CD16 -RRB- for immunoglobulin G in human sporadic amyotrophic_lateral_sclerosis -LRB- ALS -RRB- .
8405050	0	CD16	74,78	Fc_gamma_RIIIA	59,73	CD16	Fc gamma RIIIA	2214	2214	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Association of the p56lck protein tyrosine kinase with the Fc_gamma_RIIIA / CD16 complex in human natural killer cells .
2141002	0	CD16	34,38	Fc_gamma_receptor	15,32	CD16	Fc gamma receptor	2214	2209	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	-LSB- Activation of Fc_gamma_receptor -LRB- CD16 -RRB- positive natural killer cells by rheumatoid factors in rheumatoid_arthritis -RSB- .
10792496	0	CD16	37,41	FcgammaRIII	24,35	CD16	FcgammaRIII	2214	2214	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of FcgammaRIII -LRB- CD16 -RRB- by gammadelta T cells in patients with rheumatoid_arthritis .
15659493	0	CD16	31,35	FcgammaRIIIA	17,29	CD16	FcgammaRIIIA	2214	2214	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Polymorphisms in FcgammaRIIIA -LRB- CD16 -RRB- receptor expression are associated with clinical response to rituximab in Waldenstr m 's macroglobulinemia .
10380913	0	CD16	39,43	FcgammaRIIIb	25,37	CD16	FcgammaRIIIb	2214	2215	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of neutrophil FcgammaRIIIb -LRB- CD16 -RRB- surface expression following delayed apoptosis in response to GM-CSF and sodium_butyrate .
1311348	0	CD16	47,51	IFN-gamma	0,9	CD16	IFN-gamma	2214	3458	Gene	Gene	Fc_gamma_RIII|appos|START_ENTITY expression|nmod|Fc_gamma_RIII induces|dobj|expression induces|nsubj|END_ENTITY	IFN-gamma induces expression of Fc_gamma_RIII -LRB- CD16 -RRB- on human eosinophils .
21187373	0	CD16	81,85	IFN-gamma	127,136	CD16	IFN-gamma	2214	3458	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Revisiting human natural killer cell subset function revealed cytolytic CD56 -LRB- dim -RRB- CD16 + NK cells as rapid producers of abundant IFN-gamma on activation .
16078278	0	CD16	14,18	IL-15	46,51	CD16	IL-15	2214	3600	Gene	Gene	START_ENTITY|dep|cells cells|amod|END_ENTITY	Human resting CD16 - , CD16 + and IL-2 - , IL-12 - , IL-15 - or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine , lysophosphatidylcholine and platelet-activating factor .
16078278	0	CD16	21,25	IL-15	46,51	CD16	IL-15	2214	3600	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Human resting CD16 - , CD16 + and IL-2 - , IL-12 - , IL-15 - or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine , lysophosphatidylcholine and platelet-activating factor .
15325277	0	CD16	108,112	Interleukin-10	0,14	CD16	Interleukin-10	2214	3586	Gene	Gene	+|compound|START_ENTITY population|nmod|+ development|nmod|population contributes|nmod|development contributes|nsubj|END_ENTITY	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
7507963	1	CD16	161,165	L-selectin	146,156	CD16	L-selectin	2214	6402	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cleavage of L-selectin via CD16 .
25303952	0	CD16	17,21	Leptin	0,6	CD16	Leptin	2214	3952	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Leptin regulates CD16 expression on human monocytes in a sex-specific manner .
8920872	0	CD16	46,50	NKR-P1A	31,38	CD16	NKR-P1A	2214	3820	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Definition of a natural killer NKR-P1A + / CD56 - / CD16 - functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12 .
17360654	0	CD16	31,35	TGFbeta	0,7	CD16	TGFbeta	2214	7040	Gene	Gene	cells|nummod|START_ENTITY conversion|nmod|cells promotes|dobj|conversion promotes|nsubj|END_ENTITY	TGFbeta promotes conversion of CD16 + peripheral blood NK cells into CD16 - NK cells with similarities to decidual NK cells .
17360654	0	CD16	68,72	TGFbeta	0,7	CD16	TGFbeta	2214	7040	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	TGFbeta promotes conversion of CD16 + peripheral blood NK cells into CD16 - NK cells with similarities to decidual NK cells .
21791592	0	CD16	56,60	Toll-like_receptor-2	10,30	CD16	Toll-like receptor-2	2214	7097	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	Increased Toll-like_receptor-2 expression on nonclassic CD16 + monocytes from patients with inflammatory stage of Eales ' _ disease .
23595503	0	CD16	29,33	Toll-like_receptor_4	61,81	CD16	Toll-like receptor 4	2214	7099	Gene	Gene	subset|compound|START_ENTITY subset|nmod|expression expression|compound|END_ENTITY	Reduced frequency of a CD14 + CD16 + monocyte subset with high Toll-like_receptor_4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns .
7594504	0	CD16	43,47	VLA-5	111,116	CD16	VLA-5	2214	3678	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of polymorphonuclear neutrophil CD16 and CD11b/CD18 expression by matrix proteins during hypoxia is VLA-5 , VLA-6 dependent .
17591524	0	CD16	62,66	fractalkine	19,30	CD16	fractalkine	2214	6376	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	Elevated levels of fractalkine expression and accumulation of CD16 + monocytes in glomeruli of active lupus_nephritis .
8478617	0	CD16	67,71	p56lck	39,45	CD16	p56lck	14131(Tax:10090)	16818(Tax:10090)	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Physical and functional association of p56lck with Fc_gamma_RIIIA -LRB- CD16 -RRB- in natural killer cells .
19426226	0	CD160	4,9	BTLA	11,15	CD160	BTLA	11126	151888	Gene	Gene	pathway|compound|START_ENTITY pathway|appos|END_ENTITY	The CD160 , BTLA , LIGHT/HVEM pathway : a bidirectional switch regulating T-cell activation .
17218942	0	CD160	26,31	CD160	91,96	CD160	CD160	11126	11126	Gene	Gene	subset|compound|START_ENTITY Identification|nmod|subset Identification|dep|role role|nmod|END_ENTITY	Identification of a novel CD160 + CD4 + T-lymphocyte subset in the skin : a possible role for CD160 in skin_inflammation .
17218942	0	CD160	91,96	CD160	26,31	CD160	CD160	11126	11126	Gene	Gene	role|nmod|START_ENTITY Identification|dep|role Identification|nmod|subset subset|compound|END_ENTITY	Identification of a novel CD160 + CD4 + T-lymphocyte subset in the skin : a possible role for CD160 in skin_inflammation .
17218942	0	CD160	26,31	CD4	33,36	CD160	CD4	11126	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of a novel CD160 + CD4 + T-lymphocyte subset in the skin : a possible role for CD160 in skin_inflammation .
17218942	0	CD160	91,96	CD4	33,36	CD160	CD4	11126	920	Gene	Gene	role|nmod|START_ENTITY Identification|dep|role Identification|nmod|subset subset|compound|END_ENTITY	Identification of a novel CD160 + CD4 + T-lymphocyte subset in the skin : a possible role for CD160 in skin_inflammation .
18193050	0	CD160	0,5	CD4	35,38	CD160	CD4	11126	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|cells cells|compound|END_ENTITY	CD160 inhibits activation of human CD4 + T cells through interaction with herpesvirus entry mediator .
25044837	0	CD160	36,41	CD4	87,90	CD160	CD4	11126	920	Gene	Gene	expression|nmod|START_ENTITY contributes|nsubj|expression contributes|xcomp|delineate delineate|dobj|subset subset|compound|END_ENTITY	Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4 + T-lymphocyte subset in normal and mycosis_fungoides skin .
25179432	0	CD160	0,5	CD4	33,36	CD160	CD4	11126	920	Gene	Gene	isoforms|compound|START_ENTITY isoforms|nmod|responses responses|compound|END_ENTITY	CD160 isoforms and regulation of CD4 and CD8 T-cell responses .
23226545	0	CD161	47,52	CCR6	53,57	CD161	CCR6	3820	1235	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased levels of circulating IL17-producing CD161 + CCR6 + T cells are associated with graft-versus-host_disease after allogeneic stem cell transplantation .
23146786	0	CD161	19,24	CD196	25,30	CD161	CD196	3820	1235	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of CD4 + CD161 + CD196 + and CD4 + IL-17 + Th17 cells in the peripheral blood of young patients with Hashimoto 's _ thyroiditis and Graves ' _ disease -RSB- .
16365412	0	CD161	14,19	CD4	55,58	CD161	CD4	3820	920	Gene	Gene	Expression|nmod|START_ENTITY defines|nsubj|Expression defines|dobj|subsets subsets|nmod|END_ENTITY	Expression of CD161 -LRB- NKR-P1A -RRB- defines subsets of human CD4 and CD8 T cells with different functional activities .
17145807	0	CD161	45,50	CD4	23,26	CD161	CD4	3820	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing +|dobj|cells +|nsubj|frequency frequency|nmod|END_ENTITY	Increased frequency of CD4 + cells expressing CD161 in cancer patients .
18663128	0	CD161	54,59	CD4	60,63	CD161	CD4	3820	920	Gene	Gene	precursor|compound|START_ENTITY precursor|compound|END_ENTITY	Human interleukin 17-producing cells originate from a CD161 + CD4 + T cell precursor .
22084439	0	CD161	86,91	CD4	93,96	CD161	CD4	3820	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161 + CD4 + regulatory T cells .
22100877	0	CD161	30,35	CD4	62,65	CD161	CD4	3820	920	Gene	Gene	START_ENTITY|dep|cells cells|appos|+ +|dep|CD8 CD8|compound|END_ENTITY	Depletion of pro-inflammatory CD161 -LRB- + -RRB- double negative -LRB- CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- -RRB- T cells in AIDS patients is ameliorated by expansion of the y T cell population .
23146786	0	CD161	19,24	CD4	15,18	CD161	CD4	3820	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of CD4 + CD161 + CD196 + and CD4 + IL-17 + Th17 cells in the peripheral blood of young patients with Hashimoto 's _ thyroiditis and Graves ' _ disease -RSB- .
23257766	0	CD161	4,9	CD4	0,3	CD161	CD4	3820	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD161 + T lymphocytes infiltrate Crohn 's _ disease-associated_perianal_fistulas and are reduced by anti-TNF-a local therapy .
24223933	0	CD161	16,21	CD4	12,15	CD161	CD4	3820	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Circulating CD4 + CD161 + T lymphocytes are increased in seropositive arthralgia patients but decreased in patients with newly diagnosed rheumatoid_arthritis .
25960619	0	CD161	19,24	CD4	15,18	CD161	CD4	3820	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Percentages of CD4 + CD161 + and CD4-CD8-CD161 + T Cells in the Synovial Fluid Are Correlated with Disease Activity in Rheumatoid_Arthritis .
16638798	0	CD161	10,15	CD8	16,19	CD161	CD8	3820	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased CD161 + CD8 + T cells in the peripheral blood of patients suffering from rheumatic_diseases .
18219672	0	CD161	0,5	CD8	47,50	CD161	CD8	3820	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD161 expression on hepatitis_C virus-specific CD8 + T cells suggests a distinct pathway of T cell differentiation .
20133607	0	CD161	12,17	CD8	38,41	CD161	CD8	3820	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Analysis of CD161 expression on human CD8 + T cells defines a distinct functional subset with tissue-homing properties .
22100877	0	CD161	30,35	CD8	68,71	CD161	CD8	3820	925	Gene	Gene	START_ENTITY|dep|cells cells|appos|+ +|dep|END_ENTITY	Depletion of pro-inflammatory CD161 -LRB- + -RRB- double negative -LRB- CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- -RRB- T cells in AIDS patients is ameliorated by expansion of the y T cell population .
23527216	0	CD161	28,33	CD8	52,55	CD161	CD8	3820	925	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|cells cells|compound|END_ENTITY	Identification of cytolytic CD161 - CD56 + regulatory CD8 T cells in human peripheral blood .
24391773	0	CD161	25,30	CD8	32,35	CD161	CD8	3820	925	Gene	Gene	mucosal|compound|START_ENTITY mucosal|compound|END_ENTITY	Low levels of peripheral CD161 + + CD8 + mucosal associated invariant T -LRB- MAIT -RRB- cells are found in HIV_and_HIV / TB_co-infection .
24391773	7	CD161	1189,1194	CD8	1196,1199	CD161	CD8	3820	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Acute and chronic HIV were associated with lower frequencies of CD161 + + CD8 + T cells , which did not correlate with CD4 count or HIV viral load .
25960619	11	CD161	1016,1021	CD8	1012,1015	CD161	CD4	3820	920	Gene	Gene	percentage|compound|START_ENTITY percentage|compound|END_ENTITY	However , CD8 + CD161 + T cell percentage was neither changed in RA_PB and SF nor correlated with disease activity indices .
26220166	0	CD161	0,5	CD8	10,13	CD161	CD8	3820	925	Gene	Gene	START_ENTITY|dep|cells cells|nummod|END_ENTITY	CD161 -LRB- int -RRB- CD8 + T cells : a novel population of highly functional , memory CD8 + T cells enriched within the gut .
26220166	0	CD161	0,5	CD8	72,75	CD161	CD8	3820	925	Gene	Gene	START_ENTITY|dep|population population|nmod|cells cells|amod|functional functional|dep|memory memory|dep|T T|compound|END_ENTITY	CD161 -LRB- int -RRB- CD8 + T cells : a novel population of highly functional , memory CD8 + T cells enriched within the gut .
22836020	0	CD161	47,52	IL-18Ra	54,61	CD161	IL-18Ra	3820	8809	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	Analysis of stem-cell-like properties of human CD161 + + IL-18Ra + memory CD8 + T cells .
22084439	0	CD161	86,91	IL-6	13,17	CD161	IL-6	3820	3569	Gene	Gene	cells|compound|START_ENTITY emergence|nmod|cells allowing|dobj|emergence reduces|advcl|allowing reduces|nsubj|END_ENTITY	Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161 + CD4 + regulatory T cells .
24352438	0	CD161	90,95	LLT1	103,107	CD161	LLT1	3820	29121	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Respiratory_syncytial_virus_infection , TLR3 ligands , and proinflammatory cytokines induce CD161 ligand LLT1 expression on the respiratory epithelium .
16365412	0	CD161	14,19	NKR-P1A	21,28	CD161	NKR-P1A	3820	3820	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD161 -LRB- NKR-P1A -RRB- defines subsets of human CD4 and CD8 T cells with different functional activities .
11080715	0	CD162	61,66	P-selectin_glycoprotein_ligand_1	27,59	CD162	P-selectin glycoprotein ligand 1	6404	6404	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of P-selectin_glycoprotein_ligand_1 -LRB- CD162 -RRB- on human basophils .
24965453	0	CD163	14,19	ADAM17	50,56	CD163	ADAM17	9332	6868	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine_reproductive_and_respiratory_syndrome_virus entry .
19490068	0	CD163	26,31	Adiponectin	0,11	CD163	Adiponectin	9332	9370	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity .
21392045	0	CD163	11,16	CD11c	18,23	CD163	CD11c	93671(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Density of CD163 + CD11c + dendritic cells increases and CD103 + dendritic cells decreases in the coeliac_lesion .
21135497	0	CD163	6,11	CD14	0,4	CD163	CD14	9332	929	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	CD14 + CD163 + IL-10 + monocytes/macrophages : Pro-angiogenic and non pro-inflammatory isolation , enrichment and long-term secretion profile .
21691249	0	CD163	78,83	CD14	72,76	CD163	CD14	9332	929	Gene	Gene	+|compound|START_ENTITY closure|dep|+ closure|dep|role role|nmod|+ +|compound|END_ENTITY	Anatomic closure of the premature patent ductus arteriosus : The role of CD14 + / CD163 + mononuclear cells and VEGF in neointimal mound formation .
22902818	0	CD163	32,37	CD14	15,19	CD163	CD14	9332	929	Gene	Gene	CD16|appos|START_ENTITY CD16|compound|END_ENTITY	Pro-angiogenic CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD163 -LRB- + -RRB- monocytes accelerate the in vitro endothelialization of soft hydrophobic poly _ -LRB- n-butyl_acrylate -RRB- networks .
24499053	0	CD163	20,25	CD14	15,19	CD163	CD14	9332	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD16 + and CD14 + CD163 + monocyte subpopulations in kidney allograft transplantation .
25544986	0	CD163	109,114	CD14	24,28	CD163	CD14	9332	929	Gene	Gene	Normalisation|nmod|START_ENTITY +|dobj|Normalisation END_ENTITY|acl|+	Elevated Plasma Soluble CD14 and Skewed CD16 + Monocyte Distribution Persist despite Normalisation of Soluble CD163 and CXCL10 by Effective HIV Therapy : A Changing Paradigm for Routine HIV Laboratory Monitoring ?
25944005	0	CD163	0,5	CD14	6,10	CD163	CD14	9332	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD163 + CD14 + macrophages , a potential immune biomarker for malignant_pleural_effusion .
25944005	0	CD163	0,5	CD14	6,10	CD163	CD14	9332	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD163 + CD14 + macrophages , a potential immune biomarker for malignant_pleural_effusion .
12296867	0	CD163	121,126	CD163	27,32	CD163	CD163	9332	9332	Gene	Gene	the|nmod|START_ENTITY levels|nmod|the levels|nmod|END_ENTITY	Elevated levels of soluble CD163 in sera and fluids from rheumatoid_arthritis patients and inhibition of the shedding of CD163 by TIMP-3 .
12296867	0	CD163	27,32	CD163	121,126	CD163	CD163	9332	9332	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|the the|nmod|END_ENTITY	Elevated levels of soluble CD163 in sera and fluids from rheumatoid_arthritis patients and inhibition of the shedding of CD163 by TIMP-3 .
24810263	0	CD163	44,49	CD206	51,56	CD163	CD206	9332	4360	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Matrix_metalloproteinase-27 is expressed in CD163 + / CD206 + M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions .
25401296	0	CD163	14,19	CD206	21,26	CD163	CD206	9332	4360	Gene	Gene	Macrophages|compound|START_ENTITY Macrophages|compound|END_ENTITY	Comparison of CD163 + CD206 + M2 Macrophages in the Lesional Skin of Bullous Pemphigoid and Pemphigus_Vulgaris : The Possible Pathogenesis of Bullous Pemphigoid .
16640542	0	CD163	14,19	CD68	123,127	CD163	CD68	9332	968	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|comparison comparison|nmod|END_ENTITY	Expression of CD163 in dermatofibroma , cellular fibrous_histiocytoma , and dermatofibrosarcoma_protuberans : comparison with CD68 , CD34 , and Factor_XIIIa .
24515766	0	CD163	0,5	CD68	42,46	CD163	CD68	9332	968	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	CD163 immunohistochemistry is superior to CD68 in predicting outcome in classical_Hodgkin_lymphoma .
19910578	0	CD163	61,66	CXCL4	0,5	CD163	CXCL4	9332	5196	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages .
26485593	0	CD163	5,10	Iba1	13,17	CD163	Iba1	9332	199	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Anti CD163 + , Iba1 + , and CD68 + Cells in the Adult Human Inner Ear : Normal Distribution of an Unappreciated Class of Macrophages/Microglia and Implications for Inflammatory Otopathology in Humans .
15136587	0	CD163	59,64	TGF-beta	0,8	CD163	TGF-beta	9332	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	TGF-beta regulation of human macrophage scavenger receptor CD163 is Smad3-dependent .
12296867	0	CD163	121,126	TIMP-3	130,136	CD163	TIMP-3	9332	7078	Gene	Gene	the|nmod|START_ENTITY levels|nmod|the levels|nmod|END_ENTITY	Elevated levels of soluble CD163 in sera and fluids from rheumatoid_arthritis patients and inhibition of the shedding of CD163 by TIMP-3 .
12296867	0	CD163	27,32	TIMP-3	130,136	CD163	TIMP-3	9332	7078	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of soluble CD163 in sera and fluids from rheumatoid_arthritis patients and inhibition of the shedding of CD163 by TIMP-3 .
26242746	0	CD163	0,5	TWEAK	21,26	CD163	TWEAK	93671(Tax:10090)	21944(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic_injury .
11756196	0	CD163	52,57	hemoglobin_scavenger_receptor	22,51	CD163	hemoglobin scavenger receptor	9332	9332	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of the hemoglobin_scavenger_receptor / CD163 as a natural soluble protein in plasma .
19961729	0	CD163	51,56	hemoglobin_scavenger_receptor	21,50	CD163	hemoglobin scavenger receptor	9332	9332	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Association between hemoglobin_scavenger_receptor CD163 expression and coronary atherosclerotic severity in patients with coronary_heart_disease -RSB- .
11985517	0	CD163	57,62	placental_lactogen	17,35	CD163	placental lactogen	9332	1443	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of human placental_lactogen on the expression of CD163 and CD14 on human monocytes in culture .
24577568	0	CD163	84,89	substance_P	101,112	CD163	substance P	9332	6863	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	HIV_infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance_P .
23792457	0	CD164	0,5	CD26	44,48	CD164	CD26	8763	1803	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CD164 and FCRL3 are highly expressed on CD4 + CD26 - T cells in S __ zary_syndrome patients .
24756834	0	CD164	97,102	miR-219	0,7	CD164	miR-219	8763	407002	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-219 inhibits the proliferation , migration and invasion of medulloblastoma cells by targeting CD164 .
17964124	0	CD166	56,61	ALCAM	49,54	CD166	ALCAM	11658(Tax:10090)	11658(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Isolation of cardiac cells from E8 .5 yolk sac by ALCAM -LRB- CD166 -RRB- expression .
23197865	0	CD166	8,13	CD133	0,5	CD166	CD133	214	8842	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
23197865	0	CD166	8,13	CD44	14,18	CD166	CD44	214	960	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
17330143	0	CD169	14,19	Sialoadhesin	0,12	CD169	Sialoadhesin	6614	6614	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sialoadhesin -LRB- CD169 -RRB- expression in CD14 + cells is upregulated early after HIV-1_infection and increases during disease progression .
9743231	0	CD16a	53,58	Fc_gamma_receptor_IIIa	29,51	CD16a	Fc gamma receptor IIIa	2214	2214	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Enhanced upregulation of the Fc_gamma_receptor_IIIa -LRB- CD16a -RRB- during in vitro differentiation of ApoE4/4 monocytes .
22770404	0	CD16b	29,34	ADAM10	8,14	CD16b	ADAM10	2215	102	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of ADAM10 and ADAM17 in CD16b shedding mediated by different stimulators .
12763136	0	CD170	30,35	Siglec-5	20,28	CD170	Siglec-5	8778	8778	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Characterization of Siglec-5 -LRB- CD170 -RRB- expression and functional activity of anti-Siglec-5 antibodies on human phagocytes .
15238147	0	CD177	11,16	NB1_gp	18,24	CD177	NB1 gp	57126	57126	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dep|END_ENTITY	Neutrophil CD177 -LRB- NB1_gp , HNA-2a -RRB- expression is increased in severe bacterial_infections_and_polycythaemia_vera .
17580308	0	CD177	32,37	platelet_endothelial_cell_adhesion_molecule-1	64,109	CD177	platelet endothelial cell adhesion molecule-1	57126	5175	Gene	Gene	counter-receptor|nsubj|START_ENTITY counter-receptor|nmod|END_ENTITY	The neutrophil-specific antigen CD177 is a counter-receptor for platelet_endothelial_cell_adhesion_molecule-1 -LRB- CD31 -RRB- .
15061197	0	CD178	49,54	Apo-1	26,31	CD178	Apo-1	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Alterations in Fas -LRB- CD_95 / Apo-1 -RRB- and Fas_ligand -LRB- CD178 -RRB- expression in acute_promyelocytic_leukemia during treatment with ATRA .
23017670	0	CD178	24,29	CD25	5,9	CD178	CD25	356	3669	Gene	Gene	Treg|compound|START_ENTITY END_ENTITY|acl:relcl|Treg	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
23017670	0	CD178	24,29	CD4	0,3	CD178	CD4	356	920	Gene	Gene	Treg|compound|START_ENTITY CD25|acl:relcl|Treg CD25|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
11965496	0	CD178	46,51	CD95	30,34	CD178	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Genetic polymorphisms of Fas -LRB- CD95 -RRB- and FasL -LRB- CD178 -RRB- in human longevity : studies on centenarians .
16441482	0	CD178	30,35	CD95	14,18	CD178	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Study of Fas -LRB- CD95 -RRB- and FasL -LRB- CD178 -RRB- polymorphisms in liver transplant recipients .
21879377	0	CD178	58,63	CD95	42,46	CD178	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Evaluation of apoptosis-related gene Fas -LRB- CD95 -RRB- and FasL -LRB- CD178 -RRB- polymorphisms in Iranian rheumatoid_arthritis patients .
11918536	0	CD178	92,97	Fas_ligand	80,90	CD178	Fas ligand	356	356	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differentiation of promyelocytic leukaemia : alterations in Fas -LRB- CD95/Apo -1 -RRB- and Fas_ligand -LRB- CD178 -RRB- expression .
21808135	0	CD178	34,39	Fas_ligand	22,32	CD178	Fas ligand	356	356	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fas receptor -LRB- CD95 -RRB- _ Fas_ligand -LRB- CD178 -RRB- expression in patients with tobacco-related intraoral_squamous_cell_carcinoma .
23017670	0	CD178	24,29	Foxp3	11,16	CD178	Foxp3	356	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
7534799	0	CD18	73,77	ABP-280	31,38	CD18	ABP-280	3689	2318	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Direct interaction of filamin -LRB- ABP-280 -RRB- with the beta_2-integrin subunit CD18 .
12193700	0	CD18	22,26	CCR6	0,4	CD18	CCR6	3689	1235	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells .
10090940	6	CD18	803,807	CD11a	796,801	CD33	CD11c	945	3687	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	CBDC expressed CD4 , CD11a , CD18 , CD45RA , CD50 , CD54 , and CD123 , but showed no expression of CD1a , CD11c , CD33 , CD40 , CD45R0 , CD80 , CD83 , and CD86 and only limited expression of CD58 , CD102 , and CD116 .
16339524	0	CD18	0,4	CD25	61,65	CD18	CD25	16414(Tax:10090)	16184(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|cells cells|compound|END_ENTITY	CD18 is required for optimal development and function of CD4 + CD25 + T regulatory cells .
9473215	0	CD18	60,64	CD34	87,91	CD18	CD34	3689	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Retroviral-mediated gene transfer of the leukocyte integrin CD18 into peripheral blood CD34 + cells derived from a patient with leukocyte_adhesion_deficiency_type_1 .
16339524	0	CD18	0,4	CD4	57,60	CD18	CD4	16414(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|cells cells|compound|END_ENTITY	CD18 is required for optimal development and function of CD4 + CD25 + T regulatory cells .
19088063	0	CD18	33,37	CD8	29,32	CD18	CD8	3689	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Could the lower frequency of CD8 + CD18 + CD45RO + lymphocytes be biomarkers of human VL ?
9566785	0	CD18	75,79	CD8	71,74	CD18	CD8	3689	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effector T lymphocyte subsets in human pancreatic_cancer : detection of CD8 + CD18 + cells and CD8 + CD103 + cells by multi-epitope imaging .
16506060	0	CD18	153,157	ICAM-1	144,150	CD18	ICAM-1	3689	3383	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	The effects of intensive , moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 -LRB- ICAM-1 -RRB- , CD18 -LRB- beta2 integrin -RRB- and CD53 .
25322676	0	CD18	0,4	ITGB2	6,11	CD18	ITGB2	3689	3689	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD18 -LRB- ITGB2 -RRB- expression in chronic_lymphocytic_leukaemia is regulated by DNA methylation-dependent and - independent mechanisms .
7534799	0	CD18	73,77	filamin	22,29	CD18	filamin	3689	2318	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of filamin -LRB- ABP-280 -RRB- with the beta_2-integrin subunit CD18 .
24115036	0	CD180	71,76	RP105	64,69	CD180	RP105	17079(Tax:10090)	883708(Tax:272947)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	An unexpected intriguing effect of Toll-like receptor regulator RP105 -LRB- CD180 -RRB- on atherosclerosis formation with alterations on B-cell activation .
12899713	0	CD184	27,32	CXCR4	0,5	CD184	CXCR4	7852	7852	Gene	Gene	receptors|appos|START_ENTITY receptors|nummod|END_ENTITY	CXCR4 chemokine receptors -LRB- CD184 -RRB- and alpha4beta1 integrins mediate spontaneous migration of human CD34 + progenitors and acute_myeloid_leukaemia cells beneath marrow stromal cells -LRB- pseudoemperipolesis -RRB- .
25575067	0	CD19	63,67	BTLA	44,48	CD19	BTLA	930	151888	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Xinfeng Capsule increases peripheral blood BTLA expression of CD19 -LRB- + -RRB- and CD24 -LRB- + -RRB- B cells and relieves oxidative stress damage to improve cardiac function of patients with rheumatoid_arthritis -RSB- .
26660684	0	CD19	18,22	CAR	23,26	CD19	CAR	12478(Tax:10090)	12355(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Murine allogeneic CD19 CAR T-cells harbor potent anti-leukemic activity but have the potential to mediate lethal GVHD .
9477126	0	CD19	36,40	CD10	31,35	CD19	CD10	930	4311	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Prognostic significance of the CD10 + CD19 + CD34 + B-progenitor immunophenotype in children with acute_lymphoblastic_leukemia : a report from the Children 's Cancer Group .
24715427	0	CD19	17,21	CD138	10,15	CD19	CD138	930	6382	Gene	Gene	+|compound|START_ENTITY case|parataxis|+ case|nmod|END_ENTITY	A case of CD138 - / CD19 + / CD4 + IgD plasma_cell_leukemia .
9200454	0	CD19	103,107	CD19	79,83	CD19	CD19	930	930	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
9200454	0	CD19	79,83	CD19	103,107	CD19	CD19	930	930	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
1721639	0	CD19	54,58	CD20	60,64	CD19	CD20	930	54474	Gene	Gene	CD39|appos|START_ENTITY CD39|appos|END_ENTITY	Transmembrane signals generated through MHC class II , CD19 , CD20 , CD39 , and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway .
23911852	0	CD19	117,121	CD20	124,128	CD19	CD20	930	54474	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
24169729	0	CD19	23,27	CD20	17,21	CD19	CD20	930	54474	Gene	Gene	emergence|dep|START_ENTITY emergence|nmod|END_ENTITY	The emergence of CD20 - / CD19 - tumor cells after rituximab therapy for Epstein-Barr_virus-associated post-transplant_lymphoproliferative_disorder complicated with hemophagocytic_lymphohistiocytosis .
7531616	0	CD19	40,44	CD20	30,34	CD19	CD20	12478(Tax:10090)	12482(Tax:10090)	Gene	Gene	antibodies|nummod|START_ENTITY effects|nmod|antibodies effects|nmod|END_ENTITY	Enhanced antitumor effects of CD20 over CD19 monoclonal antibodies in a nude mouse xenograft model .
23189166	0	CD19	26,30	CD24	32,36	CD19	CD24	930	100133941	Gene	Gene	proportion|nmod|START_ENTITY Decrease|nmod|proportion CD27|amod|Decrease CD27|compound|END_ENTITY	Decrease in proportion of CD19 + CD24 -LRB- hi -RRB- CD27 + B cells and impairment of their suppressive function in Graves ' _ disease .
25899086	0	CD19	33,37	CD24	18,22	CD19	CD24	930	100133941	Gene	Gene	START_ENTITY|nsubj|percentage percentage|nmod|CD27 CD27|compound|END_ENTITY	Low percentage of CD24 -LRB- hi -RRB- CD27 -LRB- + -RRB- CD19 -LRB- + -RRB- B cells decelerates gastric_cancer progression in XELOX-treated patients .
26557732	0	CD19	124,128	CD24	132,136	CD19	CD24	930	100133941	Gene	Gene	activation|nmod|START_ENTITY lymphocytes|nmod|activation CD38|amod|lymphocytes CD38|compound|END_ENTITY	Effect of Stress-Free Therapy on immune system : Induction of Interleukin_10 expression in lymphocytes through activation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B Cells .
26852663	0	CD19	20,24	CD24	35,39	CD19	CD24	930	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Regulatory B cells -LRB- CD19 -LRB- + -RRB- CD38 -LRB- hi -RRB- CD24 -LRB- hi -RRB- -RRB- in alloimmunized and non-alloimmunized children with b-thalassemia major .
8172177	4	CD19	620,624	CD24	626,630	CD22	CD23	933	2208	Gene	Gene	HLA-DR|dep|START_ENTITY HLA-DR|dep|END_ENTITY	JKB-1 expressed terminal_deoxynucleotide_transferase -LRB- TdT -RRB- and early antigens -LRB- HLA-DR , CD19 , CD24 -RRB- of B cells , with heavy chain gene rearrangement .
15359642	0	CD19	38,42	CD27	46,50	CD19	CD27	930	939	Gene	Gene	+|compound|START_ENTITY +|dep|cells cells|nummod|END_ENTITY	In multiple_myeloma clonotypic CD38 - / CD19 + / CD27 + memory B cells recirculate through bone marrow , peripheral blood and lymph nodes .
23189166	0	CD19	26,30	CD27	41,45	CD19	CD27	930	939	Gene	Gene	proportion|nmod|START_ENTITY Decrease|nmod|proportion END_ENTITY|amod|Decrease	Decrease in proportion of CD19 + CD24 -LRB- hi -RRB- CD27 + B cells and impairment of their suppressive function in Graves ' _ disease .
23911852	0	CD19	117,121	CD27	144,148	CD19	CD27	930	939	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
24951896	0	CD19	17,21	CD27	36,40	CD19	CD27	930	939	Gene	Gene	IgG|compound|START_ENTITY IgG|dep|END_ENTITY	Double negative -LRB- CD19 -LRB- + -RRB- IgG -LRB- + -RRB- IgD -LRB- - -RRB- CD27 -LRB- - -RRB- -RRB- B lymphocytes : A new insight from telomerase in healthy elderly , in centenarian offspring and in Alzheimer 's _ disease patients .
25899086	0	CD19	33,37	CD27	26,30	CD19	CD27	930	939	Gene	Gene	START_ENTITY|nsubj|percentage percentage|nmod|END_ENTITY	Low percentage of CD24 -LRB- hi -RRB- CD27 -LRB- + -RRB- CD19 -LRB- + -RRB- B cells decelerates gastric_cancer progression in XELOX-treated patients .
10066438	0	CD19	55,59	CD34	63,67	CD19	CD34	12478(Tax:10090)	12490(Tax:10090)	Gene	Gene	protein|dep|START_ENTITY protein|parataxis|END_ENTITY	S. _ aureus superantigen protein A expands CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- / CD19 -LRB- + -RRB- / CD34 -LRB- + -RRB- cells in mice : a potential immunorestorer .
16225771	0	CD19	107,111	CD34	112,116	CD19	CD34	930	947	Gene	Gene	B|compound|START_ENTITY B|compound|END_ENTITY	PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19 + CD34 + B cells from patients with B cell lineage acute and chronic_lymphocytic_leukemia .
18160830	0	CD19	59,63	CD34	52,56	CD19	CD34	930	947	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD19	59,63	CD34	65,69	CD19	CD34	930	947	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|dep|+ +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18418410	0	CD19	10,14	CD34	0,4	CD19	CD34	930	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD34 + CD38 + CD19 + as well as CD34 + CD38-CD19 + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL .
24598641	0	CD19	8,12	CD34	1,5	CD19	CD34	930	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	-LSB- CD34 -LRB- + -RRB- CD19 -LRB- + -RRB- cells with CD123 overexpression are a novel prognostic marker in Ph chromosome-positive acute_lymphoblastic_leukemia -RSB- .
9057669	0	CD19	67,71	CD34	0,4	CD19	CD34	930	947	Gene	Gene	mRNA|compound|START_ENTITY express|dobj|mRNA express|nsubj|cells cells|nummod|END_ENTITY	CD34 + cells in the blood of patients with multiple_myeloma express CD19 and IgH mRNA and have patient-specific IgH VDJ gene rearrangements .
9477126	0	CD19	36,40	CD34	41,45	CD19	CD34	930	947	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Prognostic significance of the CD10 + CD19 + CD34 + B-progenitor immunophenotype in children with acute_lymphoblastic_leukemia : a report from the Children 's Cancer Group .
9593276	0	CD19	43,47	CD34	79,83	CD19	CD34	930	947	Gene	Gene	IgM|compound|START_ENTITY production|nmod|IgM system|nmod|production +|nsubj|system +|nmod|progenitors progenitors|compound|END_ENTITY	Culture system for extensive production of CD19 + IgM + cells by human cord blood CD34 + progenitors .
15359642	0	CD19	38,42	CD38	31,35	CD19	CD38	930	952	Gene	Gene	+|compound|START_ENTITY END_ENTITY|parataxis|+	In multiple_myeloma clonotypic CD38 - / CD19 + / CD27 + memory B cells recirculate through bone marrow , peripheral blood and lymph nodes .
15573184	0	CD19	61,65	CD38	79,83	CD19	CD38	930	952	Gene	Gene	CD56|nummod|START_ENTITY CD56|nummod|END_ENTITY	Flow cytometric evaluation of bone marrow plasma cells using CD19 , CD45 , CD56 , CD38 , and CD138 and correlation with bone_marrow_infiltration ratio in multiple myeloma patients .
18160830	0	CD19	59,63	CD38	46,50	CD19	CD38	930	952	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18418410	0	CD19	10,14	CD38	5,9	CD19	CD38	930	952	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD34 + CD38 + CD19 + as well as CD34 + CD38-CD19 + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL .
20079667	0	CD19	0,4	CD38	15,19	CD19	CD38	930	952	Gene	Gene	CD24|compound|START_ENTITY END_ENTITY|nsubj|CD24	CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic_Lupus_Erythematosus patients .
23755918	0	CD19	51,55	CD38	68,72	CD19	CD38	930	952	Gene	Gene	CD24|compound|START_ENTITY CD24|dep|B B|compound|END_ENTITY	An age-related numerical and functional deficit in CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- B cells is associated with an increase in systemic autoimmunity .
24935080	0	CD19	21,25	CD38	38,42	CD19	CD38	930	952	Gene	Gene	CD24|compound|START_ENTITY function|nmod|CD24 function|nmod|cells cells|amod|END_ENTITY	Impaired function of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B cells in patients with pemphigus .
26557732	0	CD19	124,128	CD38	141,145	CD19	CD38	930	952	Gene	Gene	activation|nmod|START_ENTITY lymphocytes|nmod|activation END_ENTITY|amod|lymphocytes	Effect of Stress-Free Therapy on immune system : Induction of Interleukin_10 expression in lymphocytes through activation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B Cells .
26758063	0	CD19	16,20	CD38	31,35	CD19	CD38	930	952	Gene	Gene	CD24|compound|START_ENTITY END_ENTITY|compound|CD24	Upregulation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B cells is associated with a reduced risk of acute_lung_injury in elderly pneumonia patients .
26852663	0	CD19	20,24	CD38	27,31	CD19	CD38	930	952	Gene	Gene	+|compound|START_ENTITY +|dep|CD24 CD24|compound|END_ENTITY	Regulatory B cells -LRB- CD19 -LRB- + -RRB- CD38 -LRB- hi -RRB- CD24 -LRB- hi -RRB- -RRB- in alloimmunized and non-alloimmunized children with b-thalassemia major .
7529064	0	CD19	67,71	CD38	107,111	CD19	CD38	930	952	Gene	Gene	cells|nummod|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	In multiple_myeloma , clonotypic B lymphocytes are detectable among CD19 + peripheral blood cells expressing CD38 , CD56 , and monotypic Ig light chain .
9200454	0	CD19	103,107	CD38	0,4	CD19	CD38	930	952	Gene	Gene	phosphorylation|nmod|START_ENTITY triggers|dobj|phosphorylation triggers|nsubj|ligation ligation|nummod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
9200454	0	CD19	79,83	CD38	0,4	CD19	CD38	930	952	Gene	Gene	phosphorylation|nmod|START_ENTITY triggers|dobj|phosphorylation triggers|nsubj|ligation ligation|nummod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
23911852	0	CD19	117,121	CD43	157,161	CD19	CD43	930	6693	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
25739938	0	CD19	18,22	CD45	12,16	CD19	CD45	930	5788	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	A subset of CD45 + / CD19 - cells in bone marrow may be associated with clinical outcomes of patients with mantle_cell_lymphoma .
18546943	0	CD19	33,37	CD5	38,41	CD19	CD5	930	921	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of percentage of the CD19 + CD5 + lymphocytes in hypertrophied adenoids at children with otitis media with effusion -RSB- .
21286386	0	CD19	102,106	CD5	109,112	CD19	CD5	930	921	Gene	Gene	Foxp3|nummod|START_ENTITY Foxp3|compound|END_ENTITY	Presence of Foxp3-expressing CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- B Cells in Human Peripheral Blood Mononuclear Cells : Human CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory B Cell -LRB- Breg -RRB- .
21286386	0	CD19	102,106	CD5	36,39	CD19	CD5	930	921	Gene	Gene	Foxp3|nummod|START_ENTITY Presence|dep|Foxp3 Presence|nmod|END_ENTITY	Presence of Foxp3-expressing CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- B Cells in Human Peripheral Blood Mononuclear Cells : Human CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory B Cell -LRB- Breg -RRB- .
21286386	0	CD19	29,33	CD5	109,112	CD19	CD5	930	921	Gene	Gene	CD5|compound|START_ENTITY Presence|nmod|CD5 Presence|dep|Foxp3 Foxp3|compound|END_ENTITY	Presence of Foxp3-expressing CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- B Cells in Human Peripheral Blood Mononuclear Cells : Human CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory B Cell -LRB- Breg -RRB- .
21786452	0	CD19	104,108	CD5	44,47	CD19	CD5	930	921	Gene	Gene	characterisation|nmod|START_ENTITY END_ENTITY|dep|characterisation	IL-10 is predominantly produced by CD19 -LRB- low -RRB- CD5 -LRB- + -RRB- regulatory B cell subpopulation : characterisation of CD19 -LRB- high -RRB- and CD19 -LRB- low -RRB- subpopulations of CD5 -LRB- + -RRB- B cells .
21786452	0	CD19	120,124	CD5	148,151	CD19	CD5	930	921	Gene	Gene	subpopulations|amod|START_ENTITY subpopulations|nmod|B B|compound|END_ENTITY	IL-10 is predominantly produced by CD19 -LRB- low -RRB- CD5 -LRB- + -RRB- regulatory B cell subpopulation : characterisation of CD19 -LRB- high -RRB- and CD19 -LRB- low -RRB- subpopulations of CD5 -LRB- + -RRB- B cells .
23409986	0	CD19	19,23	CD5	15,18	CD19	CD5	930	921	Gene	Gene	Cell|compound|START_ENTITY Cell|compound|END_ENTITY	Involvement of CD5 + CD19 + Cell in steroid-dependent nephrotic_syndrome treated with B-cell targeting therapy .
23507469	0	CD19	0,4	CD5	5,8	CD19	CD5	930	921	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD19 + CD5 + B cells and B1-like cells following allogeneic hematopoietic stem cell transplantation .
25516754	0	CD19	25,29	CD5	30,33	CD19	CD5	12478(Tax:10090)	12507(Tax:10090)	Gene	Gene	CD1dhiIL-10|compound|START_ENTITY CD1dhiIL-10|compound|END_ENTITY	Critical role for thymic CD19 + CD5 + CD1dhiIL-10 + regulatory B cells in immune homeostasis .
9451471	0	CD19	14,18	CD5	10,13	CD19	CD5	930	921	Gene	Gene	B|compound|START_ENTITY B|compound|END_ENTITY	Increased CD5 + CD19 + B lymphocytes at the onset of type 1 diabetes in children .
7686950	0	CD19	24,28	CD7	20,23	CD19	CD7	930	924	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of CD7 + CD19 + lymphoid cells after Epstein-Barr_virus_transformation .
23911852	0	CD19	117,121	CD70	137,141	CD19	CD70	930	970	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
14530327	0	CD19	49,53	CD81	16,20	CD19	CD81	930	975	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment .
19828092	0	CD19	19,23	CD81	0,4	CD19	CD81	930	975	Gene	Gene	lymphocytes|nummod|START_ENTITY expression|nmod|lymphocytes expression|nummod|END_ENTITY	CD81 expression on CD19 + peripheral blood lymphocytes is associated with chronic_HCV_disease and increased risk for HCV_infection : a putative role for inflammatory cytokines .
20237408	0	CD19	36,40	CD81	0,4	CD19	CD81	930	975	Gene	Gene	formation|nummod|START_ENTITY disrupts|dobj|formation disrupts|nsubj|defect defect|compound|END_ENTITY	CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody_deficiency .
9804823	0	CD19	0,4	CD9	53,56	CD19	CD9	930	928	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	CD19 is linked to the integrin-associated tetraspans CD9 , CD81 , and CD82 .
11745365	0	CD19	0,4	IFN-gamma	22,31	CD19	IFN-gamma	12478(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|END_ENTITY	CD19 -LRB- + -RRB- cells produce IFN-gamma in mice infected with Borrelia_burgdorferi .
12714520	0	CD19	0,4	RP105	57,62	CD19	RP105	12478(Tax:10090)	883708(Tax:272947)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes .
19574428	0	CD19	0,4	TLR4	96,100	CD19	TLR4	12478(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signaling signaling|compound|END_ENTITY	CD19 , a response regulator of B lymphocytes , regulates wound healing through hyaluronan-induced TLR4 signaling .
21756805	0	CD19	51,55	TOSO	43,47	CD19	TOSO	930	9214	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	-LSB- Expression and prognostic significance of TOSO in CD19 + B cells from Chinese CLL patients -RSB- .
17032003	0	CD19	104,108	Toll-like_receptor_4	120,140	CD19	Toll-like receptor 4	12478(Tax:10090)	21898(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Bovine beta-casein -LRB- 1-28 -RRB- , a casein phosphopeptide , enhances proliferation and IL-6 expression of mouse CD19 + cells via Toll-like_receptor_4 .
24698102	0	CD19	60,64	pleiotrophin	23,35	CD19	pleiotrophin	930	5764	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Elevated expression of pleiotrophin in lymphocytic_leukemia CD19 + B cells .
23146786	0	CD196	25,30	CD161	19,24	CD196	CD161	1235	3820	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of CD4 + CD161 + CD196 + and CD4 + IL-17 + Th17 cells in the peripheral blood of young patients with Hashimoto 's _ thyroiditis and Graves ' _ disease -RSB- .
23146786	0	CD196	25,30	CD4	15,18	CD196	CD4	1235	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of CD4 + CD161 + CD196 + and CD4 + IL-17 + Th17 cells in the peripheral blood of young patients with Hashimoto 's _ thyroiditis and Graves ' _ disease -RSB- .
18086588	0	CD1a	19,23	CD30	0,4	CD1a	CD30	909	943	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nummod|END_ENTITY	CD30 expression on CD1a + and CD8 + cells in atopic_dermatitis and correlation with disease severity .
9551963	0	CD1a	81,85	CD4	189,192	CD1a	CD4	909	920	Gene	Gene	cells|dep|START_ENTITY migrating|dobj|cells maturation|acl|migrating susceptible|nsubj|maturation susceptible|xcomp|anergy anergy|nmod|cells cells|amod|toxin-1 toxin-1|nmod|T T|compound|END_ENTITY	Post-thymic maturation of migrating human thymic single-positive T cells : thymic CD1a - CD4 + T cells are more susceptible to anergy induction by toxic_shock_syndrome toxin-1 than cord blood CD4 + T cells .
9551963	0	CD1a	81,85	CD4	87,90	CD1a	CD4	909	920	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Post-thymic maturation of migrating human thymic single-positive T cells : thymic CD1a - CD4 + T cells are more susceptible to anergy induction by toxic_shock_syndrome toxin-1 than cord blood CD4 + T cells .
10962529	0	CD1a	12,16	CD83	6,10	CD1a	CD83	909	9308	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	CD68 + / CD83 + / CD1a - dendritic cell subsets from patients with multiple_myeloma are not infected with human_herpesvirus_8 .
15213252	0	CD1a	94,98	CD83	105,109	CD1a	CD83	909	9308	Gene	Gene	transforms|nmod|START_ENTITY myeloid|ccomp|transforms myeloid|nsubj|END_ENTITY	IL-4 alone without the involvement of GM-CSF transforms human peripheral blood monocytes to a CD1a -LRB- dim -RRB- , CD83 -LRB- + -RRB- myeloid dendritic cell subset .
25642819	0	CD1a	42,46	T_cell_antigen_receptor	3,26	CD1a	T cell antigen receptor	909	6962	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	ab T_cell_antigen_receptor recognition of CD1a presenting self lipid ligands .
12373334	0	CD1a	111,115	factor_XIIIa	118,130	CD1a	factor XIIIa	909	2162	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses : CD1a + , factor_XIIIa + , and CD68 + cells in eczematous_dermatitis , psoriasis , lichen_planus_and_graft-versus-host_disease .
23901045	0	CD1c	64,68	BDCA-1	71,77	CD1c	BDCA-1	911	911	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Novel function for the p38-MK2 signaling pathway in circulating CD1c + -LRB- BDCA-1 + -RRB- myeloid dendritic cells from healthy donors and advanced cancer patients ; inhibition of p38 enhances IL-12 whilst suppressing IL-10 .
11034419	0	CD1d	18,22	IFN-gamma	72,81	CD1d	IFN-gamma	912	3458	Gene	Gene	Overexpression|nmod|START_ENTITY END_ENTITY|nsubj|Overexpression	Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells .
15654963	0	CD1d	17,21	TGFbeta	0,7	CD1d	TGFbeta	912	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TGFbeta inhibits CD1d expression on dendritic cells .
15790518	0	CD1d	49,53	gp120	29,34	CD1d	gp120	912	3700	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Human immunodeficiency virus gp120 downregulates CD1d cell surface expression .
25929465	0	CD1d	54,58	miR-155	13,20	CD1d	miR-155	12479(Tax:10090)	387173(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	TLR9-induced miR-155 and Ets-1 decrease expression of CD1d on B cells in SLE .
11970990	0	CD2	129,132	CD16	78,82	CD2	CD16	914	2214	Gene	Gene	cells|amod|START_ENTITY signaling|nmod|cells signaling|nummod|END_ENTITY	Alefacept , an immunomodulatory recombinant LFA-3 / IgG1 fusion protein , induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2 -LRB- + -RRB- cells .
2346908	0	CD2	96,99	CD16	120,124	CD2	CD16	914	2214	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
8104886	0	CD2	68,71	CD16	12,16	CD2	CD16	914	2214	Gene	Gene	receptors|compound|START_ENTITY mediated|nmod|receptors mediated|nsubjpass|Adhesion Adhesion|nmod|cells cells|nummod|END_ENTITY	Adhesion of CD16 + K cells to antibody-coated targets is mediated by CD2 and CD18 receptors .
11807626	0	CD2	123,126	CD25	40,44	CD2	CD25	914	3559	Gene	Gene	engagement|nummod|START_ENTITY rendered|nmod|engagement cells|acl|rendered characterizes|dobj|cells characterizes|nsubj|Down-regulation Down-regulation|nmod|IL-2_receptor_alpha IL-2_receptor_alpha|appos|END_ENTITY	Down-regulation of IL-2_receptor_alpha -LRB- CD25 -RRB- characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12 .
1356123	0	CD2	97,100	CD25	30,34	CD2	CD28	914	940	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Prolonged IL-2_receptor_alpha / CD25 expression after T cell activation via the adhesion molecules CD2 and CD28 .
21300823	0	CD2	0,3	CD25	58,62	CD2	CD25	914	3559	Gene	Gene	costimulation|compound|START_ENTITY reveals|nsubj|costimulation reveals|nmod|END_ENTITY	CD2 costimulation reveals defective activity by human CD4 + CD25 -LRB- hi -RRB- regulatory cells in patients with multiple_sclerosis .
22222639	0	CD2	118,121	CD25	55,59	CD2	CD25	914	3559	Gene	Gene	criterion|nmod:poss|START_ENTITY informative|nmod|criterion informative|nsubj|positive positive|compound|END_ENTITY	Immunophenotyping in systemic_mastocytosis diagnosis : ` CD25 positive ' alone is more informative than the ` CD25 and/or CD2 ' WHO criterion .
10458478	0	CD2	106,109	CD28	110,114	CD2	CD28	497761(Tax:10116)	25660(Tax:10116)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Better-surviving liver grafts by the injection of anti-CD2 antibody : the important roles of host CD8 + and CD2 + CD28 + T cells in chronic graft rejection and beta_type_platelet-derived_growth_factor_receptor -LRB- PDGFR-beta -RRB- expression on apoptotic liver grafts .
1670946	0	CD2	58,61	CD28	67,71	CD2	CD28	914	940	Gene	Gene	pathways|nummod|START_ENTITY pathways|nummod|END_ENTITY	IL-1_alpha is produced by T lymphocytes activated via the CD2 plus CD28 pathways .
1968076	0	CD2	70,73	CD28	81,85	CD2	CD28	914	940	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	`` CD3low '' human thymocyte populations can readily be triggered via the CD2 and/or CD28 activation pathways whereas the CD3 pathway remains nonfunctional .
7915976	0	CD2	80,83	CD28	104,108	CD2	CD28	914	940	Gene	Gene	CD43|compound|START_ENTITY CD43|dep|END_ENTITY	Primary T lymphocyte immunodeficiency associated with a selective impairment of CD2 , CD3 , CD43 -LRB- but not CD28 -RRB- - mediated signal transduction .
8902857	0	CD2	132,135	CD28	141,145	CD2	CD28	914	940	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Enhanced production of IL4 but not of IFN_gamma and IL_10 by peripheral blood mononuclear cells from atopic children in response to CD2 plus CD28 stimulation .
8913286	0	CD2	112,115	CD3_gamma	0,9	CD2	CD3 gamma	914	917	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	CD3_gamma , CD3_delta , and CD3_zeta mRNA in adult human marrow hematopoietic progenitors correlates with surface CD2 and CD7 expression .
11174380	0	CD2	0,3	CD4	5,8	CD2	CD4	914	920	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	CD2 - CD4 + CD56 + hematodermic/hematolymphoid _ malignancy .
11801645	0	CD2	0,3	CD4	35,38	CD2	CD4	12481(Tax:10090)	12504(Tax:10090)	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization .
1354232	0	CD2	0,3	CD4	135,138	CD2	CD4	914	920	Gene	Gene	triggering|compound|START_ENTITY stimulates|nsubj|triggering stimulates|nmod|alkyl-arachidonoyl-glycerophosphocholine alkyl-arachidonoyl-glycerophosphocholine|nmod|clone clone|compound|END_ENTITY	CD2 triggering stimulates the formation of platelet-activating factor-acether from alkyl-arachidonoyl-glycerophosphocholine in a human CD4 + T lymphocyte clone .
15748810	0	CD2	109,112	CD4	56,59	CD2	CD4	914	920	Gene	Gene	affect|nsubj|START_ENTITY cells|acl:relcl|affect Binding|nsubj|cells Binding|dep|gingipains gingipains|nmod|T T|compound|END_ENTITY	Binding of Porphyromonas_gingivalis gingipains to human CD4 -LRB- + -RRB- T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expression .
17904553	0	CD2	29,32	CD4	36,39	CD2	CD4	914	920	Gene	Gene	START_ENTITY|nmod|T-cell T-cell|compound|END_ENTITY	Leishmania_donovani : role of CD2 on CD4 + T-cell function in Visceral_Leishmaniasis .
18649854	0	CD2	149,152	CD4	137,140	CD2	CD4	914	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ factors|appos|cells factors|nmod|appearance appearance|nmod|END_ENTITY	Decreased maturation of T-cell populations in the healthy elderly : Influence of nutritional factors on the appearance of double negative CD4 - , CD8 - , CD2 + cells .
21300823	0	CD2	0,3	CD4	54,57	CD2	CD4	914	920	Gene	Gene	costimulation|compound|START_ENTITY reveals|nsubj|costimulation reveals|nmod|CD25 CD25|compound|END_ENTITY	CD2 costimulation reveals defective activity by human CD4 + CD25 -LRB- hi -RRB- regulatory cells in patients with multiple_sclerosis .
21767541	0	CD2	84,87	CD4	20,23	CD2	CD4	914	920	Gene	Gene	cells|nummod|START_ENTITY coculturing|dobj|cells +|advcl|coculturing +|nsubj|induction induction|nmod|CD8 CD8|compound|END_ENTITY	Marked induction of CD4 + CD8 + T cells with multifunctional properties by coculturing CD2 + cells with xenogeneic stromal cells .
2346908	0	CD2	96,99	CD4	108,111	CD2	CD4	914	920	Gene	Gene	+|compound|START_ENTITY +|appos|- -|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
23760244	0	CD2	15,18	CD4	78,81	CD2	CD4	914	920	Gene	Gene	expression|compound|START_ENTITY levels|nmod|expression identify|nsubj|levels identify|xcomp|cells cells|nsubj|T T|compound|END_ENTITY	High levels of CD2 expression identify HIV-1 latently infected resting memory CD4 + T cells in virally suppressed subjects .
2458944	0	CD2	58,61	CD4	0,3	CD2	CD4	914	920	Gene	Gene	pathway|compound|START_ENTITY activated|nmod|pathway activated|nsubjpass|cells cells|compound|END_ENTITY	CD4 + CD45R + cells are preferentially activated through the CD2 pathway .
2783435	0	CD2	101,104	CD4	14,17	CD2	CD4	914	920	Gene	Gene	triggering|nmod|START_ENTITY surface|advcl|triggering surface|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and the CD3-T cell receptor .
2783659	0	CD2	83,86	CD4	110,113	CD2	CD4	914	920	Gene	Gene	+|compound|START_ENTITY phenotype|nmod|+ lymphoma|nmod|phenotype lymphoma|appos|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
7589092	0	CD2	19,22	CD4	39,42	CD2	CD4	914	920	Gene	Gene	Ligation|nmod|START_ENTITY rescues|nsubj|Ligation rescues|dobj|cells cells|nummod|END_ENTITY	Ligation of either CD2 or CD28 rescues CD4 + T cells from HIV-gp120-induced apoptosis .
7687614	0	CD2	77,80	CD4	81,84	CD2	CD4	12481(Tax:10090)	12504(Tax:10090)	Gene	Gene	precursor|compound|START_ENTITY precursor|compound|END_ENTITY	CD2-CD4-CD8 - lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2 + CD4 + CD8 + thymic precursor .
7842346	0	CD2	5,8	CD4	10,13	CD2	CD4	914	920	Gene	Gene	-LSB-|dobj|START_ENTITY lymphocytes|advcl|-LSB- lymphocytes|nsubj|expression expression|compound|END_ENTITY	-LSB- The CD2 , CD4 and CD8 mRNA expression of T lymphocytes in patients with acromegaly and hyperprolactinemia -RSB- .
8095456	0	CD2	4,7	CD4	80,83	CD2	CD4	914	920	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	The CD2 and CD28 adhesion molecules induce long-term autocrine proliferation of CD4 + T cells .
9028954	0	CD2	0,3	CD4	70,73	CD2	CD4	12481(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|selection selection|nmod|END_ENTITY	CD2 regulates the positive selection and function of antigen-specific CD4 - CD8 + T cells .
9763034	0	CD2	22,25	CD4	27,30	CD2	CD4	914	920	Gene	Gene	START_ENTITY|dep|CD56 CD56|compound|END_ENTITY	A cutaneous agranular CD2 - CD4 + CD56 + `` lymphoma '' : report of two cases and review of the literature .
9767458	0	CD2	149,152	CD4	49,52	CD2	CD4	914	920	Gene	Gene	signalling|nmod|START_ENTITY mediated|advcl|signalling matrices|acl|mediated lymphocytes|nmod|matrices lymphocytes|nsubj|induction induction|nmod|migration migration|nmod|T T|compound|END_ENTITY	Direct and rapid induction of migration in human CD4 + T lymphocytes within three-dimensional collagen matrices mediated by signalling via CD3 and/or CD2 .
9790118	0	CD2	0,3	CD4	6,9	CD2	CD4	914	920	Gene	Gene	-|compound|START_ENTITY -|appos|+ +|compound|END_ENTITY	CD2 - , CD4 + , CD56 + agranular natural killer cell lymphoma of the skin .
9862369	0	CD2	53,56	CD4	16,19	CD2	CD4	12481(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD48|compound|START_ENTITY induced|nmod|CD48 induced|nsubj|responses responses|nummod|END_ENTITY	Enhanced murine CD4 + T cell responses induced by the CD2 ligand CD48 .
1980615	0	CD2	15,18	CD45	29,33	CD2	CD45	12481(Tax:10090)	19264(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of CD2 and T200 -LRB- CD45 -RRB- in mouse T lymphocytes .
1383383	0	CD2	37,40	CD48	0,4	CD2	CD48	12481(Tax:10090)	12506(Tax:10090)	Gene	Gene	counter-receptor|nmod|START_ENTITY counter-receptor|nsubj|END_ENTITY	CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation .
8104993	1	CD2	113,116	CD48	92,96	CD2	CD48	12481(Tax:10090)	12506(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Demonstration that CD48 is a ligand for CD2 and that CD48 adhesion is regulated by CD2 .
11981840	0	CD2	0,3	CD5	31,34	CD2	CD5	497761(Tax:10116)	54236(Tax:10116)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains .
11174380	0	CD2	0,3	CD56	10,14	CD2	CD56	914	4684	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	CD2 - CD4 + CD56 + hematodermic/hematolymphoid _ malignancy .
1371947	0	CD2	34,37	CD56	113,117	CD2	CD56	914	4684	Gene	Gene	antigens|compound|START_ENTITY lacking|dobj|antigens thymocytes|acl|lacking functional|nsubj|thymocytes functional|xcomp|endothelial endothelial|dobj|cells cells|nmod|molecules molecules|compound|END_ENTITY	Cultured human thymocytes lacking CD2 and CD11a/CD18 antigens are functional and adhere to endothelial cells via CD56 or CDw49d molecules .
22481022	0	CD2	30,33	CD56	24,28	CD2	CD56	914	4684	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	Detection of CD34 , TdT , CD56 , CD2 , CD4 , and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically_normal_acute_myeloid_leukemia .
7543014	0	CD2	23,26	CD56	35,39	CD2	CD56	914	4684	Gene	Gene	pleomorphic|dep|START_ENTITY Aggressive|xcomp|pleomorphic +|ccomp|Aggressive +|nsubj|END_ENTITY	Aggressive pleomorphic CD2 + , CD3 - , CD56 + lymphoma with t -LRB- 5 ; 9 -RRB- -LRB- q31 ; q34 -RRB- abnormality .
9790118	0	CD2	0,3	CD56	12,16	CD2	CD56	914	4684	Gene	Gene	-|compound|START_ENTITY -|appos|+ +|appos|+ +|compound|END_ENTITY	CD2 - , CD4 + , CD56 + agranular natural killer cell lymphoma of the skin .
9858215	0	CD2	93,96	CD56	119,123	CD2	CD56	914	4684	Gene	Gene	lymphoma|nmod|START_ENTITY lymphoma|appos|phenotype phenotype|compound|END_ENTITY	Establishment of an IL-2-dependent cell line derived from ` nasal-type ' NK/T-cell _ lymphoma of CD2 + , sCD3 - , CD3epsilon + , CD56 + phenotype and associated with the Epstein-Barr_virus .
7528777	0	CD2	116,119	CD58	86,90	CD2	CD58	914	965	Gene	Gene	required|nmod|START_ENTITY required|dep|END_ENTITY	Amino_acid residues required for binding of lymphocyte function-associated antigen 3 -LRB- CD58 -RRB- to its counter-receptor CD2 .
2783659	0	CD2	83,86	CD7	89,92	CD2	CD7	914	924	Gene	Gene	+|compound|START_ENTITY phenotype|nmod|+ phenotype|appos|+ +|compound|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
9379681	0	CD2	79,82	CD7	84,87	CD2	CD7	914	924	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Granulocyte-colony_stimulating_factor induces differentiation and apoptosis of CD2 , CD7 positive hybrid leukemia cells in vivo and ex vivo .
2346908	0	CD2	96,99	CD8	114,117	CD2	CD8	914	925	Gene	Gene	+|compound|START_ENTITY +|appos|- -|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
7902402	0	CD2	86,89	CHO	91,94	CD2	CD2	914	914	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effects of low-doses of X-rays on the expression of human cell surface CD2 antigen in CD2 + CHO cells .
11807626	0	CD2	123,126	IL-2_receptor_alpha	19,38	CD2	IL-2 receptor alpha	914	3559	Gene	Gene	engagement|nummod|START_ENTITY rendered|nmod|engagement cells|acl|rendered characterizes|dobj|cells characterizes|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of IL-2_receptor_alpha -LRB- CD25 -RRB- characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12 .
1356123	0	CD2	97,100	IL-2_receptor_alpha	10,29	CD2	IL-2 receptor alpha	914	3559	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Prolonged IL-2_receptor_alpha / CD25 expression after T cell activation via the adhesion molecules CD2 and CD28 .
12209631	0	CD2	181,184	LAT	106,109	CD2	LAT	914	27040	Gene	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	Lipid rafts as the signaling scaffold for NK cell activation : tyrosine phosphorylation and association of LAT with phosphatidylinositol_3-kinase and phospholipase C-gamma following CD2 stimulation .
10626910	0	CD2	56,59	LFA-3	27,32	CD2	LFA-3	914	965	Gene	Gene	cells|compound|START_ENTITY protein|nmod|cells independent|nsubj|protein Low|parataxis|independent Low|nmod|END_ENTITY	Low affinity binding of an LFA-3 / IgG1 fusion protein to CD2 + T cells is independent of cell activation .
11970990	0	CD2	129,132	LFA-3	43,48	CD2	LFA-3	914	965	Gene	Gene	cells|amod|START_ENTITY signaling|nmod|cells induces|dobj|signaling induces|nsubj|Alefacept Alefacept|appos|protein protein|compound|END_ENTITY	Alefacept , an immunomodulatory recombinant LFA-3 / IgG1 fusion protein , induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2 -LRB- + -RRB- cells .
1279193	0	CD2	54,57	LFA-3	63,68	CD2	LFA-3	914	965	Gene	Gene	interaction|nmod|START_ENTITY Enhancement|nmod|interaction Enhancement|nmod|END_ENTITY	Enhancement of B cell responses by the interaction of CD2 with LFA-3 .
1710564	0	CD2	42,45	LFA-3	6,11	CD2	LFA-3	12481(Tax:10090)	965	Gene	Gene	studied|nmod|START_ENTITY END_ENTITY|acl|studied	Mouse LFA-3 studied with chimeric soluble CD2 shows preferential expression on lymphoid cells .
2448792	0	CD2	42,45	LFA-3	141,146	CD2	LFA-3	914	965	Gene	Gene	Expression|nmod|START_ENTITY mutant|nsubj|Expression mutant|xcomp|define define|dobj|role role|nmod|antigen antigen|appos|END_ENTITY	Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 -LRB- LFA-3 -RRB- in T-cell activation .
2458315	0	CD2	89,92	LFA-3	10,15	CD2	LFA-3	914	965	Gene	Gene	gene|nmod|START_ENTITY located|nmod|gene located|nsubjpass|gene gene|compound|END_ENTITY	The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2 .
2459236	0	CD2	93,96	LFA-3	51,56	CD2	LFA-3	914	965	Gene	Gene	pathway|compound|START_ENTITY thymocytes|nmod|pathway activates|dobj|thymocytes activates|nsubj|lymphocyte_function-associated_antigen-3 lymphocyte_function-associated_antigen-3|appos|END_ENTITY	Purified lymphocyte_function-associated_antigen-3 -LRB- LFA-3 -RRB- activates human thymocytes via the CD2 pathway .
2460248	0	CD2	19,22	LFA-3	32,37	CD2	LFA-3	914	965	Gene	Gene	START_ENTITY|nmod|ligand ligand|compound|END_ENTITY	The interaction of CD2 with its LFA-3 ligand expressed by autologous erythrocytes results in enhancement of B cell responses .
2471647	0	CD2	36,39	LFA-3	25,30	CD2	LFA-3	914	965	Gene	Gene	ligand|compound|START_ENTITY antibody|appos|ligand antibody|nmod|END_ENTITY	A monoclonal antibody to LFA-3 , the CD2 ligand , specifically immobilizes major histocompatibility complex proteins .
2834437	0	CD2	15,18	LFA-3	36,41	CD2	LFA-3	914	965	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CD2 with its ligand , LFA-3 , in human T cell proliferation .
3313052	0	CD2	88,91	LFA-3	3,8	CD2	LFA-3	914	965	Gene	Gene	protein|nmod|START_ENTITY encodes|dobj|protein encodes|nsubj|cDNA cDNA|compound|END_ENTITY	An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2 .
7505442	0	CD2	111,114	LFA-3	10,15	CD2	LFA-3	914	965	Gene	Gene	domain|compound|START_ENTITY face|nmod|domain area|nmod|face area|nsubj|CD58 CD58|appos|END_ENTITY	The CD58 -LRB- LFA-3 -RRB- binding site is a localized and highly charged surface area on the AGFCC ` C '' face of the human CD2 adhesion domain .
7520278	0	CD2	29,32	LFA-3	45,50	CD2	LFA-3	914	965	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Human cell-adhesion molecule CD2 binds CD58 -LRB- LFA-3 -RRB- with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59 .
8636222	0	CD2	17,20	LFA-3	38,43	CD2	LFA-3	914	965	Gene	Gene	Visualization|nmod|START_ENTITY interaction|nsubj|Visualization interaction|nmod|END_ENTITY	Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area .
15162436	0	CD2	48,51	NTBA	26,30	CD2	NTBA	914	114836	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Homophilic interaction of NTBA , a member of the CD2 molecular family : induction of cytotoxicity and cytokine release in human NK cells .
15528362	0	CD2	26,29	STAT5	17,22	CD2	STAT5	914	6776	Gene	Gene	activation|compound|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression .
2455894	0	CD2	30,33	T11	25,28	CD2	T11	914	914	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Adhesion domain of human T11 -LRB- CD2 -RRB- is encoded by a single exon .
2894031	0	CD2	74,77	T11	69,72	CD2	T11	12481(Tax:10090)	110621(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Exon-intron organization and sequence comparison of human and murine T11 -LRB- CD2 -RRB- genes .
2896210	0	CD2	18,21	T11	13,16	CD2	T11	914	914	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for T11 -LRB- CD2 -RRB- maps to chromosome 1 in humans and to chromosome 3 in mice .
8093441	0	CD2	15,18	T_cell_receptor	36,51	CD2	T cell receptor	914	6962	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	Alterations of CD2 association with T_cell_receptor signaling molecules in `` CD2 unresponsive '' human T lymphocytes .
22481022	0	CD2	30,33	TdT	19,22	CD2	TdT	914	1791	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	Detection of CD34 , TdT , CD56 , CD2 , CD4 , and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically_normal_acute_myeloid_leukemia .
3106791	0	CD2	72,75	c-myc	0,5	CD2	c-myc	914	4609	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	c-myc gene expression and interleukin-2 receptor levels in cloned human CD2 + , CD3 + and CD2 + , CD3 - lymphocytes .
17658775	0	CD2	118,121	cluster_of_differentiation_2	88,116	CD2	cluster of differentiation 2	914	914	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Structure-based rational design of beta-hairpin peptides from discontinuous epitopes of cluster_of_differentiation_2 -LRB- CD2 -RRB- protein to modulate cell adhesion interaction .
9677430	0	CD2	69,72	fyn	19,22	CD2	fyn	914	2534	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of p59 -LRB- fyn -RRB- with the T lymphocyte costimulatory receptor CD2 .
10642604	0	CD2	15,18	galectin-1	30,40	CD2	galectin-1	914	3956	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells .
7519476	0	CD2	57,60	interleukin-2	100,113	CD2	interleukin-2	914	3558	Gene	Gene	ligation|compound|START_ENTITY ligation|nmod|END_ENTITY	Maturation of acute_T-lymphoblastic_leukemia cells after CD2 ligation and subsequent treatment with interleukin-2 .
1358625	1	CD2	96,99	p56lck	165,171	CD2	p56lck	914	3932	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|END_ENTITY	CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck .
9677430	0	CD2	69,72	p59	15,18	CD2	p59	914	26003	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of p59 -LRB- fyn -RRB- with the T lymphocyte costimulatory receptor CD2 .
24940003	0	CD2	4,7	protocadherin-15	19,35	CD2	protocadherin-15	914	65217	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells .
15951437	0	CD2-associated_protein	0,22	CD2AP	24,29	CD2-associated protein	CD2AP	12488(Tax:10090)	12488(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD2-associated_protein -LRB- CD2AP -RRB- expression in podocytes rescues lethality of CD2AP_deficiency .
16753590	0	CD20	8,12	CD10	13,17	CD20	CD10	54474	4311	Gene	Gene	+|nsubj|START_ENTITY +|dobj|T-cell_lymphoma T-cell_lymphoma|compound|END_ENTITY	Primary CD20 + CD10 + CD8 + T-cell_lymphoma of the skin with IgH and TCR_beta gene rearrangement .
1721639	0	CD20	60,64	CD19	54,58	CD20	CD19	54474	930	Gene	Gene	CD39|appos|START_ENTITY CD39|appos|END_ENTITY	Transmembrane signals generated through MHC class II , CD19 , CD20 , CD39 , and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway .
23911852	0	CD20	124,128	CD19	117,121	CD20	CD19	54474	930	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
24169729	0	CD20	17,21	CD19	23,27	CD20	CD19	54474	930	Gene	Gene	emergence|nmod|START_ENTITY emergence|dep|END_ENTITY	The emergence of CD20 - / CD19 - tumor cells after rituximab therapy for Epstein-Barr_virus-associated post-transplant_lymphoproliferative_disorder complicated with hemophagocytic_lymphohistiocytosis .
7531616	0	CD20	30,34	CD19	40,44	CD20	CD19	12482(Tax:10090)	12478(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|antibodies antibodies|nummod|END_ENTITY	Enhanced antitumor effects of CD20 over CD19 monoclonal antibodies in a nude mouse xenograft model .
21841127	0	CD20	23,27	CD20	8,12	CD20	CD20	54474	54474	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells .
21841127	0	CD20	8,12	CD20	23,27	CD20	CD20	54474	54474	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells .
1380783	0	CD20	64,68	CD23	69,73	CD20	CD23	54474	2208	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating elevated levels of soluble CD23 , interleukin-4 , and CD20 + CD23 + lymphocytes in atopic subjects with elevated serum IgE concentrations .
7509812	0	CD20	0,4	CD23	113,117	CD20	CD23	54474	2208	Gene	Gene	antibodies|nummod|START_ENTITY stimulate|nsubj|antibodies stimulate|dobj|cleavage cleavage|nmod|receptor receptor|nmod|IgE IgE|appos|END_ENTITY	CD20 monoclonal antibodies stimulate extracellular cleavage of the low affinity receptor for IgE -LRB- Fc_epsilon_RII / CD23 -RRB- in Epstein-Barr-transformed B cells .
7542593	0	CD20	0,4	CD23	125,129	CD20	CD23	54474	2208	Gene	Gene	antibodies|nummod|START_ENTITY decrease|nsubj|antibodies decrease|dobj|expression expression|nmod|receptor receptor|nmod|IgE IgE|appos|END_ENTITY	CD20 monoclonal antibodies decrease interleukin-4-stimulated expression of the low-affinity receptor for IgE -LRB- Fc_epsilon_RII / CD23 -RRB- in human B cells by increasing the extent of its cleavage .
21220451	0	CD20	88,92	CD27	94,98	CD20	CD27	54474	939	Gene	Gene	CD70|compound|START_ENTITY CD70|compound|END_ENTITY	Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 + CD27 + CD43 + CD70 - .
22553348	0	CD20	0,4	CD27	54,58	CD20	CD27	54474	939	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ have|nsubj|lymphocytes have|dobj|END_ENTITY	CD20 + tumor-infiltrating lymphocytes have an atypical CD27 - memory phenotype and together with CD8 + T cells promote favorable prognosis in ovarian_cancer .
22566872	0	CD20	38,42	CD27	79,83	CD20	CD27	54474	939	Gene	Gene	plasmablasts|compound|START_ENTITY generation|nmod|plasmablasts induces|dobj|generation induces|nmod|B-cells B-cells|compound|END_ENTITY	TLR9 ligand induces the generation of CD20 + plasmablasts and plasma cells from CD27 + memory B-cells .
23911852	0	CD20	124,128	CD27	144,148	CD20	CD27	54474	939	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
21220451	0	CD20	88,92	CD43	100,104	CD20	CD43	54474	6693	Gene	Gene	CD70|compound|START_ENTITY CD70|compound|END_ENTITY	Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 + CD27 + CD43 + CD70 - .
23911852	0	CD20	124,128	CD43	157,161	CD20	CD43	54474	6693	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
16867907	0	CD20	99,103	CD5	34,37	CD20	CD5	54474	921	Gene	Gene	down-modulation|nmod|START_ENTITY intravascular|nmod|down-modulation intravascular|nsubj|relapse relapse|nmod|+ +|compound|END_ENTITY	Leukemic and meningeal relapse of CD5 + intravascular large B-cell_lymphoma with down-modulation of CD20 after rituximab therapy .
1715005	0	CD20	25,29	CD5	20,23	CD20	CD5	54474	921	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changing pattern of CD5 + CD20 + double positive lymphocytes with ageing and cytotoxic chemotherapy .
25318949	0	CD20	75,79	CD5	0,3	CD20	CD5	54474	921	Gene	Gene	Expression|compound|START_ENTITY B-Cell_Lymphoma|nmod|Expression Large|dobj|B-Cell_Lymphoma Large|nsubj|Diffuse Diffuse|amod|END_ENTITY	CD5 - and CD23-Positive Splenic Diffuse Large B-Cell_Lymphoma with Very Low CD20 Expression .
7526015	0	CD20	65,69	CD5	71,74	CD20	CD5	54474	921	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|dep|cells cells|nummod|END_ENTITY	-LSB- Chronic cold_agglutinin_disease accompanied with an increase of CD20 + / CD5 + cells ; a case report -RSB- .
23911852	0	CD20	124,128	CD70	137,141	CD20	CD70	54474	970	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
11587221	0	CD20	0,4	CD8	119,122	CD20	CD8	54474	925	Gene	Gene	antibody|nummod|START_ENTITY antibody|nmod|cells cells|nummod|END_ENTITY	CD20 antibody -LRB- C2B8 -RRB- - induced apoptosis of lymphoma cells promotes phagocytosis by dendritic cells and cross-priming of CD8 + cytotoxic T cells .
12580963	0	CD20	82,86	CD8	13,16	CD20	CD8	54474	925	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels cells|ccomp|express cells|compound|END_ENTITY	Expansion of CD8 + T cells that express low levels of the B cell-specific molecule CD20 in patients with multiple_myeloma .
16753590	0	CD20	8,12	CD8	18,21	CD20	CD8	54474	925	Gene	Gene	+|nsubj|START_ENTITY +|dobj|T-cell_lymphoma T-cell_lymphoma|compound|END_ENTITY	Primary CD20 + CD10 + CD8 + T-cell_lymphoma of the skin with IgH and TCR_beta gene rearrangement .
21574977	0	CD20	167,171	CD8	155,158	CD20	CD8	54474	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immunophenotype of skin lymphocytic infiltrate in patients co-infected with Mycobacterium_leprae and human_immunodeficiency_virus : a scenario dependent on CD8 + and/or CD20 + cells .
22553348	0	CD20	0,4	CD8	95,98	CD20	CD8	54474	925	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ have|nsubj|lymphocytes have|advmod|together together|nmod|cells cells|compound|END_ENTITY	CD20 + tumor-infiltrating lymphocytes have an atypical CD27 - memory phenotype and together with CD8 + T cells promote favorable prognosis in ovarian_cancer .
23683422	0	CD20	63,67	CD8	21,24	CD20	CD8	54474	925	Gene	Gene	coexpressed|dobj|START_ENTITY coexpressed|nsubj|cytotoxic_T-cell_lymphoma cytotoxic_T-cell_lymphoma|compound|END_ENTITY	-LSB- Primary bone marrow CD8 cytotoxic_T-cell_lymphoma coexpressed CD20 : a case report and literatures review -RSB- .
7545683	0	CD20	109,113	Lyn	66,69	CD20	Lyn	54474	4067	Gene	Gene	kinases|nmod|START_ENTITY kinases|dobj|END_ENTITY	Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn , Fyn , and Lck with the B cell molecule CD20 .
21072172	0	CD20	10,14	MS4a4B	0,6	CD20	MS4a4B	12482(Tax:10090)	60361(Tax:10090)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	MS4a4B , a CD20 homologue in T cells , inhibits T cell propagation by modulation of cell cycle .
7691952	1	CD20	95,99	phospholipase_C-gamma_1_and_PLC_phospholipase_C-gamma_2	146,201	CD20	phospholipase C-gamma 1 and PLC phospholipase C-gamma 2	54474	5335	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction via CD20 of tyrosine phosphorylation and activation of phospholipase_C-gamma_1_and_PLC_phospholipase_C-gamma_2 .
16183870	0	CD200	7,12	CK7	14,17	CD200	CK7	17470(Tax:10090)	110310(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Murine CD200 + CK7 + trophoblasts in a poly -LRB- I : C -RRB- - induced embryo resorption model .
18008004	0	CD200	0,5	ERK	20,23	CD200	ERK	4345	5594	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	CD200 is induced by ERK and is a potential therapeutic target in melanoma .
17624239	0	CD203C	48,54	Interleukin-3	0,13	CD203C	Interleukin-3	5169	3562	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Interleukin-3 promotes the expression of E-NPP3 / CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy .
24419414	0	CD204	17,22	CD14	12,16	CD204	CD14	4481	929	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD14 + CD204 + cells predict postoperative recurrence in non-small-cell lung_cancer patients .
24599281	0	CD206	111,116	CD14	106,110	CD206	CD14	4360	929	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Moraxella_catarrhalis adhesin UspA1-derived recombinant fragment rD-7 induces monocyte differentiation to CD14 + CD206 + phenotype .
24810263	0	CD206	51,56	CD163	44,49	CD206	CD163	4360	9332	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Matrix_metalloproteinase-27 is expressed in CD163 + / CD206 + M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions .
25401296	0	CD206	21,26	CD163	14,19	CD206	CD163	4360	9332	Gene	Gene	Macrophages|compound|START_ENTITY Macrophages|compound|END_ENTITY	Comparison of CD163 + CD206 + M2 Macrophages in the Lesional Skin of Bullous Pemphigoid and Pemphigus_Vulgaris : The Possible Pathogenesis of Bullous Pemphigoid .
12884872	0	CD207	46,51	Langerin	36,44	CD207	Langerin	50489	50489	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	TNF-alpha induces the generation of Langerin / -LRB- CD207 -RRB- + immature Langerhans-type dendritic cells from both CD14-CD1a and CD14 + CD1a - precursors derived from CD34 + cord blood cells .
21081145	0	CD209	46,51	DC-SIGN	37,44	CD209	DC-SIGN	30835	30835	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relationship between polymorphism of DC-SIGN -LRB- CD209 -RRB- gene and the susceptibility to pulmonary_tuberculosis in an eastern Chinese population .
11884427	0	CD209	9,14	IL-4	30,34	CD209	IL-4	30835	3565	Gene	Gene	dependent|dep|START_ENTITY dependent|advmod|END_ENTITY	DC-SIGN -LRB- CD209 -RRB- expression is IL-4 dependent and is negatively regulated by IFN , TGF-beta , and anti-inflammatory agents .
20713631	0	CD209	42,47	Interleukin-4	0,13	CD209	Interleukin-4	30835	3565	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium_leprae by Schwann cells in human leprosy .
21304587	0	CD21	16,20	CD27	21,25	CD21	CD27	1380	939	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Double-positive CD21 + CD27 + B cells are highly proliferating memory cells and their distribution differs in mucosal and peripheral tissues .
21622026	0	CD21	127,131	CD27	132,136	CD21	CD27	1380	712693(Tax:9544)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Simian_immunodeficiency_virus infection in rhesus_macaques induces selective tissue specific B cell defects in double positive CD21 + CD27 + memory B cells .
1688740	0	CD21	18,22	CR2	4,7	CD21	CR2	1380	1380	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The CR2 receptor -LRB- CD21 -RRB- shows increased expression in the more differentiated cells of an antigen-specific B cell line .
1835941	0	CD21	39,43	CR2	34,37	CD21	CR2	1380	1380	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of complement receptor CR2 -LRB- CD21 -RRB- on human subcorneal keratinocytes in normal and diseased skin .
20394560	0	CD21	97,101	CR2	92,95	CD21	CR2	1380	1380	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	The Splenic White Pulp in Chronic_Lymphocytic_Leukaemia : A Microenvironment Associated with CR2 -LRB- CD21 -RRB- Expression , Cell Transformation and Proliferation .
12244142	0	CD21	48,52	complement_receptor_type_2	20,46	CD21	complement receptor type 2	1380	1380	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human complement_receptor_type_2 -LRB- CD21 -RRB- in mice during early B cell development results in a reduction in mature B cells and hypogammaglobulinemia .
25326368	0	CD210	148,153	IL-10	142,147	CD210	IL-10	3587	3586	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	Bone Marrow Mesenchymal Stromal Cells Induce Proliferative , Cytokinic and Molecular Changes During the T Cell Response : The Importance of the IL-10 / CD210 Axis .
12646615	0	CD22	22,26	AP50	43,47	CD22	AP50	933	1173	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	The B cell coreceptor CD22 associates with AP50 , a clathrin-coated pit adapter protein , via tyrosine-dependent interaction .
26561584	0	CD22	61,65	CD45	30,34	CD22	CD45	933	5788	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|function function|nmod|END_ENTITY	An extracatalytic function of CD45 in B cells is mediated by CD22 .
8757957	0	CD22	27,31	Lyb8	33,37	CD22	Lyb8	12483(Tax:10090)	12483(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of CD22 -LRB- Lyb8 -RRB- on murine B cells .
19150402	0	CD22	13,17	SAP	0,3	CD22	SAP	933	4068	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux .
15668918	0	CD22	23,27	SLP-76	0,6	CD22	SLP-76	12483(Tax:10090)	16822(Tax:10090)	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	SLP-76 is recruited to CD22 and dephosphorylated by SHP-1 , thereby regulating B cell receptor-induced c-Jun_N-terminal_kinase activation .
12213789	0	CD22	24,28	ST6Gal_I	43,51	CD22	ST6Gal I	12483(Tax:10090)	20440(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|mice mice|amod|END_ENTITY	Constitutively unmasked CD22 on B cells of ST6Gal_I knockout mice : novel sialoside probe for murine CD22 .
20200274	0	CD22	0,4	Siglec-G	7,15	CD22	Siglec-G	12483(Tax:10090)	243958(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity .
9127741	1	CD22	152,156	haptoglobin	119,130	CD22	haptoglobin	933	3240	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of haptoglobin to the B-cell lectin CD22 .
8627166	0	CD22	0,4	protein_tyrosine_phosphatase_1C	21,52	CD22	protein tyrosine phosphatase 1C	933	5777	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	CD22 associates with protein_tyrosine_phosphatase_1C , Syk , and phospholipase_C-gamma -LRB- 1 -RRB- upon B cell activation .
12775570	0	CD223	106,111	LAG-3	91,96	CD223	LAG-3	3902	3902	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	MHC class II signal transduction in human dendritic cells induced by a natural ligand , the LAG-3 protein -LRB- CD223 -RRB- .
22429743	0	CD226	0,5	CD155	23,28	CD226	CD155	225825(Tax:10090)	52118(Tax:10090)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	CD226 interaction with CD155 impacts on retention and negative selection of CD8 positive thymocytes as well as T cell differentiation to follicular helper cells in Peyer 's Patches .
21750737	0	CD226	32,37	CD4	49,52	CD226	CD4	225825(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	RTL551 treatment of EAE reduces CD226 and T-bet + CD4 T cells in periphery and prevents infiltration of T-bet + IL-17 , IFN-y producing T cells into CNS .
26109642	0	CD226	10,15	CD8	30,33	CD226	CD8	10666	925	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Increased CD226 Expression on CD8 + T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic_Sclerosis .
15039383	0	CD226	39,44	DNAM-1	31,37	CD226	DNAM-1	225825(Tax:10090)	10666	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of DNAM-1 -LRB- CD226 -RRB- interaction with its ligands PVR -LRB- CD155 -RRB- and nectin-2 -LRB- PRR-2 / CD112 -RRB- .
26675069	0	CD226	22,27	DNAM-1	14,20	CD226	DNAM-1	10666	10666	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of DNAM-1 -LRB- CD226 -RRB- on inflammatory monocytes .
12372344	0	CD227	70,75	MUC1	64,68	CD227	MUC1	4582	4582	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive and inducible expression of the epithelial antigen MUC1 -LRB- CD227 -RRB- in human T cells .
1380783	0	CD23	69,73	CD20	64,68	CD23	CD20	2208	54474	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating elevated levels of soluble CD23 , interleukin-4 , and CD20 + CD23 + lymphocytes in atopic subjects with elevated serum IgE concentrations .
7509812	0	CD23	113,117	CD20	0,4	CD23	CD20	2208	54474	Gene	Gene	IgE|appos|START_ENTITY receptor|nmod|IgE cleavage|nmod|receptor stimulate|dobj|cleavage stimulate|nsubj|antibodies antibodies|nummod|END_ENTITY	CD20 monoclonal antibodies stimulate extracellular cleavage of the low affinity receptor for IgE -LRB- Fc_epsilon_RII / CD23 -RRB- in Epstein-Barr-transformed B cells .
7542593	0	CD23	125,129	CD20	0,4	CD23	CD20	2208	54474	Gene	Gene	IgE|appos|START_ENTITY receptor|nmod|IgE expression|nmod|receptor decrease|dobj|expression decrease|nsubj|antibodies antibodies|nummod|END_ENTITY	CD20 monoclonal antibodies decrease interleukin-4-stimulated expression of the low-affinity receptor for IgE -LRB- Fc_epsilon_RII / CD23 -RRB- in human B cells by increasing the extent of its cleavage .
12006207	0	CD23	87,91	CD4	24,27	CD23	CD4	2208	920	Gene	Gene	CLL|compound|START_ENTITY patients|nmod|CLL END_ENTITY|nmod|patients	Selection of autologous CD4 + T-cells for adoptive T-cell substitution in patients with CD23 + B-cell CLL .
1673432	0	CD23	48,52	CD4	76,79	CD23	CD4	2208	920	Gene	Gene	START_ENTITY|nmod|growth growth|nmod|bone bone|compound|END_ENTITY	Synergistic effect of interleukin_1 and soluble CD23 on the growth of human CD4 + bone marrow-derived T cells .
7910139	0	CD23	17,21	CD4	25,28	CD23	CD4	2208	920	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Allergen-induced CD23 on CD4 + T lymphocytes and CD21 on B lymphocytes in patients with allergic_asthma : evidence and regulation .
9420139	0	CD23	132,136	CD4	127,130	CD23	CD4	2208	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
16585575	0	CD23	43,47	Fc_epsilonRII	49,62	CD23	Fc epsilonRII	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential T cell-mediated regulation of CD23 -LRB- Fc_epsilonRII -RRB- in B cells and follicular dendritic cells .
1830067	5	CD23	645,649	Fc_epsilon_RII	630,644	CD23	Fc epsilon RII	2208	2208	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Using two-dimensional flow cytometry , more than 10 % of the Fc_epsilon_RII / CD23 + cells were found to co-express CD3 Ag .
7547698	0	CD23	48,52	Fc_epsilon_RII	33,47	CD23	Fc epsilon RII	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TNF-alpha regulates IL-4-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
7692241	2	CD23	404,408	Fc_epsilon_RII	389,403	CD23	Fc epsilon RII	2208	2208	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Zymosan opsonized with human serum enhanced not only the expression of surface Fc_epsilon_RII / CD23 but also Fc_epsilon_RII / CD23 mRNA detected by Northern blot and in situ hybridization techniques .
7947461	0	CD23	30,34	Fc_epsilon_RII	15,29	CD23	Fc epsilon RII	2208	2208	Gene	Gene	pathway|compound|START_ENTITY Involvement|dep|pathway Involvement|nmod|END_ENTITY	Involvement of Fc_epsilon_RII / CD23 and L-arginine-dependent pathway in IgE-mediated stimulation of human monocyte functions .
8039805	0	CD23	84,88	Fc_epsilon_RII	69,83	CD23	Fc epsilon RII	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Purified excretory-secretory component of filarial parasite enhances Fc_epsilon_RII / CD23 expression on human splenic B and T cells and IgE synthesis while potentiating T-helper type 2-related cytokine generation from T cells .
8074665	0	CD23	30,34	Fc_epsilon_RII	15,29	CD23	Fc epsilon RII	2208	2208	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Fc_epsilon_RII / CD23 and L-arginine dependent pathway in IgE-mediated activation of human eosinophils .
8144928	0	CD23	41,45	Fc_epsilon_RII	25,39	CD23	Fc epsilon RII	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of the murine Fc_epsilon_RII -LRB- CD23 -RRB- gene .
8559149	0	CD23	19,23	Fc_epsilon_RII	4,18	CD23	Fc epsilon RII	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The Fc_epsilon_RII / CD23 gene is actively transcribed during all stages of murine B-lymphocyte development .
8722638	0	CD23	72,76	Fc_epsilon_RII	57,71	CD23	Fc epsilon RII	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Granulocyte_macrophage_colony_stimulating_factor induces Fc_epsilon_RII / CD23 expression on normal human polymorphonuclear neutrophils .
9100439	0	CD23	53,57	Fc_epsilon_RII	38,52	CD23	Fc epsilon RII	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Effects of anti-IgE mAb on serum IgE , Fc_epsilon_RII / CD23 expression on splenic B cells and worm burden in mice infected with Paragonimus_westermani .
1682274	0	CD23	77,81	Fc_epsilon_receptor_II	54,76	CD23	Fc epsilon receptor II	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Beta-2-adrenoceptor agonists up-regulate the in vitro Fc_epsilon_receptor_II / CD23 expression on , and release from , the promonocytic cell line U937 and human blood monocytes .
10482830	0	CD23	77,81	FcepsilonRII	63,75	CD23	FcepsilonRII	2208	2208	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression and action of the low-affinity IgE receptor FcepsilonRII -LRB- CD23 -RRB- in asthmatic airway_smooth_muscle .
8722638	0	CD23	72,76	Granulocyte_macrophage_colony_stimulating_factor	0,48	CD23	Granulocyte macrophage colony stimulating factor	2208	1437	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Granulocyte_macrophage_colony_stimulating_factor induces Fc_epsilon_RII / CD23 expression on normal human polymorphonuclear neutrophils .
8133030	0	CD23	14,18	IL-4	33,37	CD23	IL-4	2208	3565	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of CD23 expression by IL-4 and corticosteroid in human B lymphocytes .
16172256	0	CD23	23,27	IgE	54,57	CD23	IgE	2208	3497	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure of human CD23 and its interactions with IgE and CD21 .
22802656	0	CD23	54,58	IgE	21,24	CD23	IgE	2208	3497	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc __ RI .
8938103	0	CD23	43,47	Interleukin-7	0,13	CD23	Interleukin-7	2208	3574	Gene	Gene	production|compound|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Interleukin-7 modulates intracytoplasmatic CD23 production and induces adhesion molecule expression and adhesiveness in activated CD4 + CD23 + T cell subsets .
9420139	0	CD23	132,136	LFA-1	49,54	CD23	LFA-1	2208	3683	Gene	Gene	subset|compound|START_ENTITY role|nmod|subset role|nmod|molecules molecules|amod|interleukin-7 interleukin-7|nmod|induction induction|nmod|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
19995395	0	CD23	57,61	NOTCH2	0,6	CD23	NOTCH2	2208	4853	Gene	Gene	expression|nmod|START_ENTITY links|nmod|expression links|nsubj|END_ENTITY	NOTCH2 links protein_kinase_C_delta to the expression of CD23 in chronic_lymphocytic_leukaemia -LRB- CLL -RRB- cells .
11986231	0	CD23	44,48	Notch2	0,6	CD23	Notch2	2208	4853	Gene	Gene	overexpression|nmod|START_ENTITY involved|nmod|overexpression involved|nsubjpass|END_ENTITY	Notch2 is involved in the overexpression of CD23 in B-cell_chronic_lymphocytic_leukemia .
15621797	0	CD23	14,18	Notch2	33,39	CD23	Notch2	2208	4853	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of CD23 expression by Notch2 in B-cell_chronic_lymphocytic_leukemia .
9796920	0	CD23	30,34	STAT6	0,5	CD23	STAT6	14128(Tax:10090)	20852(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	STAT6 , NF-kappaB and C/EBP in CD23 expression and IgE production .
7547698	0	CD23	48,52	TNF-alpha	0,9	CD23	TNF-alpha	2208	7124	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TNF-alpha regulates IL-4-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
9122614	0	CD23	67,71	TNF-alpha	0,9	CD23	TNF-alpha	2208	7124	Gene	Gene	expression|compound|START_ENTITY -|dep|expression -|compound|END_ENTITY	TNF-alpha regulates GM-CSF - , _ IL-3 - or M-CSF-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
22815482	0	CD23	15,19	immunoglobulin_E	36,52	CD23	immunoglobulin E	2208	3497	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Mapping of the CD23 binding site on immunoglobulin_E -LRB- IgE -RRB- and allosteric control of the IgE-Fc epsilonRI interaction .
14700442	0	CD23	14,18	interferon-gamma	78,94	CD23	interferon-gamma	2208	3458	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|role role|nmod|END_ENTITY	Regulation of CD23 in the chronic inflammatory response in asthma : a role for interferon-gamma and heat_shock_protein_70 in the TH2 environment .
9420139	0	CD23	132,136	interleukin-7	15,28	CD23	interleukin-7	2208	3574	Gene	Gene	subset|compound|START_ENTITY role|nmod|subset role|nmod|molecules molecules|amod|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
1321789	0	CD23	76,80	latent_membrane_protein	26,49	CD23	latent membrane protein	2208	9260	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|expression expression|nmod|END_ENTITY	The expression of the EBV latent_membrane_protein -LRB- LMP-1 -RRB- is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin 's _ disease .
26298632	0	CD24	55,59	ALDH1	74,79	CD24	ALDH1	100133941	216	Gene	Gene	expressions|compound|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
20689763	0	CD24	120,124	Artemin	0,7	CD24	Artemin	100133941	9048	Gene	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	Artemin Reduces Sensitivity to Doxorubicin and Paclitaxel in Endometrial_Carcinoma Cells through Specific Regulation of CD24 .
19288016	0	CD24	64,68	CCL5	114,118	CD24	CCL5	100133941	6352	Gene	Gene	START_ENTITY|dep|phenotype phenotype|nmod|cells cells|nmod|expression expression|compound|END_ENTITY	Role of CCL5 in invasion , proliferation and proportion of CD44 + / CD24 - phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast_cancer progression .
19288016	0	CD24	64,68	CCL5	8,12	CD24	CCL5	100133941	6352	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of CCL5 in invasion , proliferation and proportion of CD44 + / CD24 - phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast_cancer progression .
12886247	0	CD24	139,143	CD10	131,135	CD24	CD10	25145(Tax:10116)	24590(Tax:10116)	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Expression of the human homologue of rat NG2 in adult acute_lymphoblastic_leukemia : close association with MLL rearrangement and a CD10 -LRB- - -RRB- / CD24 -LRB- - -RRB- / CD65s -LRB- + -RRB- / CD15 -LRB- + -RRB- B-cell phenotype .
1531306	0	CD24	155,159	CD10	180,184	CD24	CD10	100133941	4311	Gene	Gene	BA-1|dep|START_ENTITY BA-1|dep|END_ENTITY	Autologous bone marrow transplantation in high-risk remission B-lineage acute_lymphoblastic_leukemia using a cocktail of three monoclonal antibodies -LRB- BA-1 / CD24 , BA-2 / CD9 , and BA-3 / CD10 -RRB- plus complement and 4-hydroperoxycyclophosphamide for ex vivo bone marrow purging .
26298632	0	CD24	55,59	CD133	67,72	CD24	CD133	100133941	8842	Gene	Gene	expressions|compound|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
12886247	0	CD24	139,143	CD15	156,160	CD24	CD15	25145(Tax:10116)	2526	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Expression of the human homologue of rat NG2 in adult acute_lymphoblastic_leukemia : close association with MLL rearrangement and a CD10 -LRB- - -RRB- / CD24 -LRB- - -RRB- / CD65s -LRB- + -RRB- / CD15 -LRB- + -RRB- B-cell phenotype .
23189166	0	CD24	32,36	CD19	26,30	CD24	CD19	100133941	930	Gene	Gene	CD27|compound|START_ENTITY CD27|amod|Decrease Decrease|nmod|proportion proportion|nmod|END_ENTITY	Decrease in proportion of CD19 + CD24 -LRB- hi -RRB- CD27 + B cells and impairment of their suppressive function in Graves ' _ disease .
25899086	0	CD24	18,22	CD19	33,37	CD24	CD19	100133941	930	Gene	Gene	CD27|compound|START_ENTITY percentage|nmod|CD27 END_ENTITY|nsubj|percentage	Low percentage of CD24 -LRB- hi -RRB- CD27 -LRB- + -RRB- CD19 -LRB- + -RRB- B cells decelerates gastric_cancer progression in XELOX-treated patients .
26557732	0	CD24	132,136	CD19	124,128	CD24	CD19	100133941	930	Gene	Gene	CD38|compound|START_ENTITY CD38|amod|lymphocytes lymphocytes|nmod|activation activation|nmod|END_ENTITY	Effect of Stress-Free Therapy on immune system : Induction of Interleukin_10 expression in lymphocytes through activation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B Cells .
26852663	0	CD24	35,39	CD19	20,24	CD24	CD19	100133941	930	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Regulatory B cells -LRB- CD19 -LRB- + -RRB- CD38 -LRB- hi -RRB- CD24 -LRB- hi -RRB- -RRB- in alloimmunized and non-alloimmunized children with b-thalassemia major .
8172177	4	CD24	626,630	CD19	620,624	CD23	CD22	2208	933	Gene	Gene	HLA-DR|dep|START_ENTITY HLA-DR|dep|END_ENTITY	JKB-1 expressed terminal_deoxynucleotide_transferase -LRB- TdT -RRB- and early antigens -LRB- HLA-DR , CD19 , CD24 -RRB- of B cells , with heavy chain gene rearrangement .
22997842	0	CD24	51,55	CD38	16,20	CD24	CD38	100133941	952	Gene	Gene	role|nmod|START_ENTITY role|nmod|biomarker biomarker|compound|END_ENTITY	Pivotal role of CD38 biomarker in combination with CD24 , EpCAM , and ALDH for identification of H460 derived lung_cancer stem cells .
23755918	0	CD24	59,63	CD38	68,72	CD24	CD38	100133941	952	Gene	Gene	START_ENTITY|dep|B B|compound|END_ENTITY	An age-related numerical and functional deficit in CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- B cells is associated with an increase in systemic autoimmunity .
24094028	0	CD24	0,4	CD38	6,10	CD24	CD38	100133941	952	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	CD24 + / CD38 - as new prognostic marker for non-small cell lung_cancer .
24935080	0	CD24	29,33	CD38	38,42	CD24	CD38	100133941	952	Gene	Gene	function|nmod|START_ENTITY function|nmod|cells cells|amod|END_ENTITY	Impaired function of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B cells in patients with pemphigus .
15709183	0	CD24	20,24	CD44	14,18	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Prevalence of CD44 + / CD24 - / low cells in breast_cancer may not be associated with clinical outcome but may favor distant metastasis .
17062128	0	CD24	6,10	CD44	0,4	CD24	CD44	12484(Tax:10090)	12505(Tax:10090)	Gene	Gene	properties|dep|START_ENTITY properties|nummod|+ +|compound|END_ENTITY	CD44 + / CD24 - breast_cancer cells exhibit enhanced invasive properties : an early step necessary for metastasis .
17179479	0	CD24	16,20	CD44	28,32	CD24	CD44	100133941	960	Gene	Gene	response|nmod|START_ENTITY response|dep|cells cells|nummod|END_ENTITY	The response of CD24 -LRB- - / low -RRB- / CD44 + breast_cancer-initiating cells to radiation .
18495204	0	CD24	81,85	CD44	53,57	CD24	CD44	100133941	960	Gene	Gene	cells|nummod|START_ENTITY significance|dep|cells significance|nmod|CD24 CD24|compound|END_ENTITY	The clinicopathologic and prognostic significance of CD44 + / CD24 -LRB- - / low -RRB- and CD44 - / CD24 + tumor cells in invasive breast_carcinomas .
18559090	0	CD24	10,14	CD44	4,8	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	The CD44 + / CD24 - phenotype is enriched in basal-like breast_tumors .
18931706	0	CD24	64,68	CD44	58,62	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	-LSB- Pilot study on the correlation between high incidence of CD44 + / CD24 - / low/ABCG2 - cells and poor prognosis in breast_cancer -RSB- .
18931707	0	CD24	20,24	CD44	14,18	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	-LSB- Isolation of CD44 + / CD24 - / low and side population cells from MDA-MB-453 cells and the analysis of their activation of Wnt and Notch pathway -RSB- .
19048252	0	CD24	55,59	CD44	49,53	CD24	CD44	100133941	960	Gene	Gene	lo|compound|START_ENTITY lo|compound|END_ENTITY	Breast_cancer cells expressing stem cell markers CD44 + CD24 lo are eliminated by Numb-1 peptide-activated T cells .
19288016	0	CD24	64,68	CD44	58,62	CD24	CD44	100133941	960	Gene	Gene	Role|dep|START_ENTITY Role|nmod|+ +|compound|END_ENTITY	Role of CCL5 in invasion , proliferation and proportion of CD44 + / CD24 - phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast_cancer progression .
19794958	0	CD24	48,52	CD44	40,44	CD24	CD44	100133941	960	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Tumor-endothelial interaction links the CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- phenotype with poor prognosis in early-stage_breast_cancer .
20004947	0	CD24	21,25	CD44	13,17	CD24	CD44	100133941	960	Gene	Gene	breast_cancer|nsubj|START_ENTITY Reduction|parataxis|breast_cancer Reduction|nmod|END_ENTITY	Reduction of CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- breast_cancer cells by conventional cytotoxic chemotherapy .
20043317	0	CD24	16,20	CD44	8,12	CD24	CD44	100133941	960	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	ALDH -LRB- + -RRB- / CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- expression in cells from body cavity fluids .
20199686	0	CD24	46,50	CD44	40,44	CD24	CD44	100133941	960	Gene	Gene	regain|parataxis|START_ENTITY regain|nmod|+ +|compound|END_ENTITY	Selective regain of egfr gene copies in CD44 + / CD24 - / low breast_cancer cellular model MDA-MB-468 .
20377923	0	CD24	49,53	CD44	43,47	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Radiation resistance in breast_cancer : are CD44 + / CD24 - / proteosome low/PKH26 + cells to blame ?
20405247	0	CD24	10,14	CD44	4,8	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	The CD44 + / CD24 - phenotype relates to ` triple-negative ' state and unfavorable prognosis in breast_cancer patients .
20569497	0	CD24	65,69	CD44	60,64	CD24	CD44	100133941	960	Gene	Gene	CXCR4|compound|START_ENTITY CXCR4|compound|END_ENTITY	Breast_cancer stromal fibroblasts promote the generation of CD44 + CD24 - cells through SDF-1 / CXCR4 interaction .
20691079	0	CD24	70,74	CD44	64,68	CD24	CD44	100133941	960	Gene	Gene	phenotype|dep|START_ENTITY phenotype|compound|END_ENTITY	SLUG/SNAI2 and tumor_necrosis_factor generate breast cells with CD44 + / CD24 - phenotype .
20977976	0	CD24	46,50	CD44	40,44	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	The clinicopathological significance of CD44 + / CD24 - / low and CD24 + tumor cells in invasive micropapillary_carcinoma_of_the_breast .
21044318	0	CD24	17,21	CD44	11,15	CD24	CD44	100133941	960	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|END_ENTITY	Increasing CD44 + / CD24 -LRB- - -RRB- tumor stem cells , and upregulation of COX-2 and HDAC6 , as major functions of HER2 in breast tumorigenesis .
21299347	0	CD24	8,12	CD44	0,4	CD24	CD44	100133941	960	Gene	Gene	cells|compound|START_ENTITY progenitors|nsubj|cells progenitors|nsubj|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- cells are transit progenitors and do not determine the molecular subtypes and clinical parameters in breast_carcinomas .
21444368	0	CD24	42,46	CD44	34,38	CD24	CD44	100133941	960	Gene	Gene	cells|compound|START_ENTITY cells|amod|radioresistance radioresistance|nmod|/ /|compound|END_ENTITY	STAT1 promotes radioresistance of CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- cells in breast_cancer .
21503107	0	CD24	128,132	CD44	121,125	CD24	CD44	100133941	960	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Dendritic cells infected by recombinant adeno-associated virus with CEA gene to induce antigen-specific CTL response to CD44 -LRB- + -RRB- CD24 -LRB- - / low -RRB- cells from MCF-7 breast_cancer cell line -RSB- .
21835433	0	CD24	8,12	CD44	0,4	CD24	CD44	100133941	960	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- cancer stem/progenitor cells are more abundant in triple-negative invasive breast_carcinoma phenotype and are associated with poor outcome .
21838786	0	CD24	41,45	CD44	32,36	CD24	CD44	100133941	960	Gene	Gene	START_ENTITY|nsubj|evaluation evaluation|nmod|/ /|compound|END_ENTITY	Semi-quantitative evaluation of CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- tumor cell distribution in breast_cancer tissue using a newly developed fluorescence immunohistochemical staining method .
21882047	0	CD24	23,27	CD44	18,22	CD24	CD44	12484(Tax:10090)	12505(Tax:10090)	Gene	Gene	gastric_cancer|compound|START_ENTITY gastric_cancer|compound|END_ENTITY	Identification of CD44 + CD24 + gastric_cancer stem cells .
21935375	0	CD24	45,49	CD44	39,43	CD24	CD44	100133941	960	Gene	Gene	cells|amod|START_ENTITY mediated|nsubjpass|cells resistance|parataxis|mediated resistance|nmod|+ +|compound|END_ENTITY	The phenotypic radiation resistance of CD44 + / CD24 -LRB- - or low -RRB- breast_cancer cells is mediated through the enhanced activation of ATM signaling .
22031797	0	CD24	10,14	CD44	4,8	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Can CD44 + / CD24 - Tumor Cells Be Used to Determine the Extent of Breast_Cancer_Invasion Following Neoadjuvant Chemotherapy ?
22119938	0	CD24	10,14	CD44	2,6	CD24	CD44	100133941	960	Gene	Gene	phenotype|compound|START_ENTITY marker|nsubj|phenotype END_ENTITY|parataxis|marker	A CD44 / CD24 phenotype is a poor prognostic marker in early invasive breast_cancer .
22322379	0	CD24	50,54	CD44	55,59	CD24	CD44	100133941	960	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Epithelial mesenchymal transition correlates with CD24 + CD44 + and CD133 + cells in pancreatic_cancer .
22702496	0	CD24	31,35	CD44	25,29	CD24	CD44	100133941	960	Gene	Gene	implications|dep|START_ENTITY implications|nmod|+ +|compound|END_ENTITY	Clinical implications of CD44 + / CD24 - tumor cell ratio in breast_cancer .
22762532	0	CD24	6,10	CD44	0,4	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	CD44 + / CD24 - phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive_ductal_carcinoma .
22771536	0	CD24	36,40	CD44	30,34	CD24	CD44	100133941	960	Gene	Gene	cells|dep|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Highly sensitive profiling of CD44 + / CD24 - breast_cancer stem cells by combining global mRNA amplification and next generation sequencing : evidence for a hyperactive PI3K pathway .
22855175	0	CD24	6,10	CD44	0,4	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	CD44 + / CD24 - breast_cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties .
23028444	0	CD24	32,36	CD44	26,30	CD24	CD44	100133941	960	Gene	Gene	START_ENTITY|nmod|identification identification|nmod|+ +|compound|END_ENTITY	In situ identification of CD44 + / CD24 - cancer cells in primary human breast_carcinomas .
23197865	0	CD24	25,29	CD44	30,34	CD24	CD44	100133941	960	Gene	Gene	+|compound|START_ENTITY phenotypes|nummod|+ phenotypes|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
23346166	0	CD24	52,56	CD44	44,48	CD24	CD44	100133941	960	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of bFGF on the MCF-7 Cell Cycle with CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- : Promoting the G0/G1 > G2/S Transition .
23589132	0	CD24	18,22	CD44	12,16	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Response of CD44 + / CD24 - / low breast_cancer stem/progenitor cells to tamoxifen - and doxorubicin - induced autophagy .
24167614	0	CD24	102,106	CD44	88,92	CD24	CD44	100133941	960	Gene	Gene	+|compound|START_ENTITY low|nmod|+ +|advmod|low +|compound|END_ENTITY	Triple_negative_breast_tumors in African-American and Hispanic/Latina women are high in CD44 + , low in CD24 + , and have loss of PTEN .
24366074	0	CD24	18,22	CD44	12,16	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	The role of CD44 + / CD24 - / low biomarker for screening , diagnosis and monitoring of breast_cancer .
24376586	0	CD24	55,59	CD44	49,53	CD24	CD44	12484(Tax:10090)	12505(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Evaluation of STAT3 signaling in ALDH + and ALDH + / CD44 + / CD24 - subpopulations of breast_cancer cells .
24519209	0	CD24	97,101	CD44	91,95	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	ALDH1 is a better clinical indicator for relapse of invasive_ductal_breast_cancer than the CD44 + / CD24 - phenotype .
25130168	0	CD24	17,21	CD44	9,13	CD24	CD44	100133941	960	Gene	Gene	population|compound|START_ENTITY drives|nmod|population drives|nsubj|END_ENTITY	Enriched CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- population drives the aggressive phenotypes presented in triple-negative breast_cancer -LRB- TNBC -RRB- .
25541438	0	CD24	101,105	CD44	93,97	CD24	CD44	100133941	960	Gene	Gene	tumor-initiating_subpopulation_in_basal-like_breast_cancer|compound|START_ENTITY HES1-mediated|nsubj|tumor-initiating_subpopulation_in_basal-like_breast_cancer HES1-mediated|dep|vitamin_D vitamin_D|nmod|END_ENTITY	HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin_D analog leads to decreased CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- tumor-initiating_subpopulation_in_basal-like_breast_cancer .
25695620	0	CD24	144,148	CD44	136,140	CD24	CD44	100133941	960	Gene	Gene	Cells|compound|START_ENTITY Cells|amod|Interleukin-8 Interleukin-8|dep|Induction Induction|nmod|END_ENTITY	Human Umbilical Cord Mesenchymal Stem Cells Promote Breast_Cancer_Metastasis by Interleukin-8 - _ and_Interleukin-6-Dependent Induction of CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- Cells .
25945050	0	CD24	8,12	CD44	0,4	CD24	CD44	100133941	960	Gene	Gene	breast_cancer|nsubj|START_ENTITY breast_cancer|nsubj|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- breast_cancer cells exhibit phenotypic reversion in three-dimensional self-assembling peptide RADA16 nanofiber scaffold .
25945050	0	CD24	8,12	CD44	0,4	CD24	CD44	100133941	960	Gene	Gene	breast_cancer|nsubj|START_ENTITY breast_cancer|nsubj|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- breast_cancer cells exhibit phenotypic reversion in three-dimensional self-assembling peptide RADA16 nanofiber scaffold .
26173453	0	CD24	6,10	CD44	0,4	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	CD44 + / CD24 - Cancer Stem Cells Are Associated With Higher Grade of Canine Mammary Carcinomas .
26298632	0	CD24	55,59	CD44	61,65	CD24	CD44	100133941	960	Gene	Gene	expressions|compound|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
26366219	0	CD24	77,81	CD44	69,73	CD24	CD44	100133941	960	Gene	Gene	/|dobj|START_ENTITY /|nsubj|+ +|compound|END_ENTITY	Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells -LRB- CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- -RRB- in MCF-7 by Upregulating Mucin1 and EpCAM .
26617852	6	CD24	795,799	CD44	787,791	CD24	CD44	100133941	960	Gene	Gene	CD44|dep|START_ENTITY CD44|dep|CD24 CD24|appos|- -|compound|END_ENTITY	We applied double-staining immunohistochemistry for the detection of CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- , CD44 -LRB- + -RRB- / CD24 -LRB- + -RRB- , CD44 -LRB- - -RRB- / CD24 -LRB- - -RRB- and CD44 -LRB- - -RRB- / CD24 -LRB- + -RRB- cells .
26772398	0	CD24	66,70	CD44	60,64	CD24	CD44	100133941	960	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Decreased expression of autophagy protein LC3 and stemness -LRB- CD44 + / CD24 - / low -RRB- indicate poor prognosis in triple-negative_breast_cancer .
16930538	0	CD24	53,57	E-cadherin	14,24	CD24	E-cadherin	100133941	999	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of E-cadherin and TGF-beta3 expression by CD24 in cultured oral epithelial cells .
26830684	0	CD24	0,4	EGFR	21,25	CD24	EGFR	100133941	1956	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric_cancer cells .
9129046	0	CD24	0,4	P-selectin	49,59	CD24	P-selectin	100133941	6403	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	CD24 , a mucin-type glycoprotein , is a ligand for P-selectin on human tumor cells .
26788063	0	CD24	14,18	TGFb3	90,95	CD24	TGFb3	100133941	7043	Gene	Gene	Expression|nmod|START_ENTITY Regulated|nsubjpass|Expression Regulated|nmod|END_ENTITY	Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFb3 and Induces a Myofibroblast-Like Genotype .
24193512	0	CD24	75,79	Twist2	0,6	CD24	Twist2	100133941	117581	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Twist2 promotes self-renewal of liver_cancer stem-like cells by regulating CD24 .
23346166	0	CD24	52,56	bFGF	10,14	CD24	bFGF	100133941	2247	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of bFGF on the MCF-7 Cell Cycle with CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- : Promoting the G0/G1 > G2/S Transition .
8753773	0	CD24	15,19	c-fgr	36,41	CD24	c-fgr	100133941	2268	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CD24 with the kinase c-fgr in a small_cell_lung_cancer cell line and with the kinase lyn in an erythroleukemia cell line .
8226859	0	CD24	31,35	heat_stable_antigen	4,23	CD24	heat stable antigen	12484(Tax:10090)	12484(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The heat_stable_antigen -LRB- mouse CD24 -RRB- gene is differentially regulated but has a housekeeping promoter .
23533633	0	CD24	0,4	miR-21	39,45	CD24	miR-21	100133941	406991	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	CD24 induces expression of the oncomir miR-21 via Src , and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a .
25658602	0	CD24	12,16	miR-21	51,57	CD24	miR-21	100133941	406991	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Correction : CD24 Induces Expression of the Oncomir miR-21 via Src , and CD24 and Src Are Both Post-Transcriptionally Downregulated by the Tumor Suppressor miR-34a .
25769721	0	CD24	97,101	miR-21	0,6	CD24	miR-21	12484(Tax:10090)	387140(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Liver_Fibrosis|nmod|Cells Liver_Fibrosis|amod|END_ENTITY	miR-21 Inhibition Reduces Liver_Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24 + Progenitor Cells .
25769721	0	CD24	97,101	miR-21	0,6	CD24	miR-21	12484(Tax:10090)	387140(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Liver_Fibrosis|nmod|Cells Liver_Fibrosis|amod|END_ENTITY	miR-21 Inhibition Reduces Liver_Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24 + Progenitor Cells .
15850375	0	CD244	55,60	2B4	50,53	CD244	2B4	51744	51744	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|END_ENTITY	NMR structure of the natural killer cell receptor 2B4 -LRB- CD244 -RRB- : implications for ligand recognition .
16177062	0	CD244	37,42	Vav	70,73	CD244	Vav	51744	7409	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling , ERK activation , and NK cell killing .
27049955	0	CD25	82,86	4-1BB	0,5	CD25	4-1BB	3559	3604	Gene	Gene	Suppression|compound|START_ENTITY Production|dep|Suppression Production|nsubj|Signaling Signaling|nummod|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
26063731	0	CD25	52,56	Androgen_receptor	0,17	CD25	Androgen receptor	3559	367	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells modulates|dobj|expression modulates|nsubj|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
19654865	0	CD25	63,67	CCR4	52,56	CD25	CCR4	3559	1233	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|levels levels|nmod|CD4 CD4|compound|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
16002422	0	CD25	52,56	CCR5	18,22	CD25	CCR5	16184(Tax:10090)	12774(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	Critical role for CCR5 in the function of donor CD4 + CD25 + regulatory T cells during acute_graft-versus-host_disease .
15613550	0	CD25	73,77	CCR6	0,4	CD25	CCR6	3559	1235	Gene	Gene	CD4|compound|START_ENTITY defines|nmod|CD4 defines|nsubj|expression expression|compound|END_ENTITY	CCR6 expression defines regulatory effector/memory-like cells within the CD25 -LRB- + -RRB- CD4 + T-cell subset .
21400499	0	CD25	36,40	CCR6	42,46	CD25	CCR6	16184(Tax:10090)	12458(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-22 is produced by yC-independent CD25 + CCR6 + innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality .
12193715	0	CD25	25,29	CCR7	125,129	CD25	CCR7	16184(Tax:10090)	12775(Tax:10090)	Gene	Gene	+|compound|START_ENTITY subpopulation|nmod|+ splenocytes|nsubj|subpopulation splenocytes|ccomp|expresses expresses|dobj|levels levels|nmod|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
17371928	0	CD25	50,54	CCR7	0,4	CD25	CCR7	16184(Tax:10090)	12775(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells required|nmod|function required|nsubjpass|END_ENTITY	CCR7 is required for the in vivo function of CD4 + CD25 + regulatory T cells .
15699124	0	CD25	59,63	CCR8	0,4	CD25	CCR8	16184(Tax:10090)	12776(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	CCR8 is expressed by antigen-elicited , IL-10-producing CD4 + CD25 + T cells , which regulate Th2-mediated granuloma formation in mice .
18576316	0	CD25	13,17	CD127	83,88	CD25	CD127	3559	3575	Gene	Gene	+|appos|START_ENTITY +|dep|sensitivity sensitivity|nmod|CD4 CD4|nummod|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
19667968	0	CD25	29,33	CD127	0,5	CD25	CD127	3669	3575	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	CD127 -LRB- low -RRB- expression in CD4 + CD25 -LRB- high -RRB- T cells as immune biomarker of renal function in transplant patients .
21413939	0	CD25	92,96	CD127	34,39	CD25	CD127	3559	3575	Gene	Gene	FoxP3|compound|START_ENTITY T|nmod|FoxP3 T|dep|matures matures|dobj|forkhead_box_P3 forkhead_box_P3|compound|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	CD25	92,96	CD127	83,88	CD25	CD127	3559	3575	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|amod|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21799858	0	CD25	107,111	CD127	100,105	CD25	CD127	3559	3575	Gene	Gene	cells|compound|START_ENTITY generated|nsubj|cells +|parataxis|generated +|nmod|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
22734240	0	CD25	58,62	CD127	64,69	CD25	CD127	3559	3575	Gene	Gene	significance|nmod|START_ENTITY significance|dep|END_ENTITY	-LSB- Clinical significance and detection of the expression of CD25 - CD127 - on CD4 + T cells in peripheral blood in patients with hepatitis_B -RSB- .
23257455	0	CD25	19,23	CD127	26,31	CD25	CD127	16184(Tax:10090)	16197(Tax:10090)	Gene	Gene	Analysis|nmod|START_ENTITY END_ENTITY|nsubj|Analysis	-LSB- Analysis of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- Treg cells in mice -RSB- .
23466550	0	CD25	35,39	CD127	45,50	CD25	CD127	3669	3575	Gene	Gene	medium|nmod|START_ENTITY Impact|nmod|medium END_ENTITY|nsubj|Impact	Impact of culture medium on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- lo/neg -RRB- Treg expansion for the purpose of clinical application .
26333292	0	CD25	19,23	CD127	27,32	CD25	CD127	3559	3575	Gene	Gene	Decrease|nmod|START_ENTITY FoxP3|amod|Decrease FoxP3|compound|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
15111929	0	CD25	0,4	CD134	69,74	CD25	CD134	3559	7293	Gene	Gene	distinguishes|compound|START_ENTITY subsets|nsubj|distinguishes subsets|nsubj|T-cell T-cell|compound|END_ENTITY	CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 -LRB- OX40 -RRB- T-cell subsets in acute_graft-versus-host_disease .
16380476	0	CD25	16,20	CD134	31,36	CD25	CD134	3559	7293	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Coexpression of CD25 and OX40 -LRB- CD134 -RRB- receptors delineates autoreactive T-cells in type 1 diabetes .
18723571	0	CD25	4,8	CD134	40,45	CD25	CD134	3559	7293	Gene	Gene	populations|compound|START_ENTITY populations|acl|expressing expressing|dobj|END_ENTITY	CD4 + CD25 + T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener 's _ granulomatosis .
24752698	0	CD25	30,34	CD134	38,43	CD25	CD134	3669	7293	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
24797972	0	CD25	69,73	CD134	25,30	CD25	CD134	3559	7293	Gene	Gene	cells|amod|START_ENTITY molecules|nmod|cells molecules|nsubj|expression expression|nmod|OX40 OX40|appos|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
24797972	0	CD25	69,73	CD137	43,48	CD25	CD137	3559	3604	Gene	Gene	cells|amod|START_ENTITY molecules|nmod|cells molecules|nsubj|expression expression|nmod|OX40 OX40|appos|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
14662196	0	CD25	14,18	CD152	20,25	CD25	CD152	3559	1493	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Evaluation of CD25 , CD152 , Fas-ligand expression in the adenoids of allergic and non-allergic children : a pilot study .
22749982	0	CD25	66,70	CD152	13,18	CD25	CD152	3559	1493	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
23017670	0	CD25	5,9	CD178	24,29	CD25	CD178	3669	356	Gene	Gene	START_ENTITY|acl:relcl|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
16339524	0	CD25	61,65	CD18	0,4	CD25	CD18	16184(Tax:10090)	16414(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells required|nmod|development required|nsubjpass|END_ENTITY	CD18 is required for optimal development and function of CD4 + CD25 + T regulatory cells .
11807626	0	CD25	40,44	CD2	123,126	CD25	CD2	3559	914	Gene	Gene	IL-2_receptor_alpha|appos|START_ENTITY Down-regulation|nmod|IL-2_receptor_alpha characterizes|nsubj|Down-regulation characterizes|dobj|cells cells|acl|rendered rendered|nmod|engagement engagement|nummod|END_ENTITY	Down-regulation of IL-2_receptor_alpha -LRB- CD25 -RRB- characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12 .
1356123	0	CD25	30,34	CD2	97,100	CD28	CD2	940	914	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Prolonged IL-2_receptor_alpha / CD25 expression after T cell activation via the adhesion molecules CD2 and CD28 .
21300823	0	CD25	58,62	CD2	0,3	CD25	CD2	3559	914	Gene	Gene	reveals|nmod|START_ENTITY reveals|nsubj|costimulation costimulation|compound|END_ENTITY	CD2 costimulation reveals defective activity by human CD4 + CD25 -LRB- hi -RRB- regulatory cells in patients with multiple_sclerosis .
22222639	0	CD25	55,59	CD2	118,121	CD25	CD2	3559	914	Gene	Gene	positive|compound|START_ENTITY informative|nsubj|positive informative|nmod|criterion criterion|nmod:poss|END_ENTITY	Immunophenotyping in systemic_mastocytosis diagnosis : ` CD25 positive ' alone is more informative than the ` CD25 and/or CD2 ' WHO criterion .
12028564	0	CD25	4,8	CD25	75,79	CD25	CD25	3559	3559	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|ccomp|suppress suppress|dobj|proliferation proliferation|nmod|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12028564	0	CD25	75,79	CD25	4,8	CD25	CD25	3559	3559	Gene	Gene	proliferation|nmod|START_ENTITY suppress|dobj|proliferation lymphocytes|ccomp|suppress lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
14991599	0	CD25	143,147	CD25	58,62	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY counter-regulated|nmod|cells cells|acl:relcl|counter-regulated Demonstration|dep|cells Demonstration|nmod|reactivity reactivity|nmod|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991599	0	CD25	58,62	CD25	143,147	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	reactivity|nmod|START_ENTITY Demonstration|nmod|reactivity Demonstration|dep|cells cells|acl:relcl|counter-regulated counter-regulated|nmod|cells cells|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
15630140	0	CD25	19,23	CD25	41,45	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|dep|cells cells|nmod|+ +|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15630140	0	CD25	41,45	CD25	19,23	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ Conversion|dep|cells Conversion|nmod|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15728475	0	CD25	47,51	CD25	77,81	CD25	CD25	3559	3559	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD25	77,81	CD25	47,51	CD25	CD25	3559	3559	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15753318	0	CD25	43,47	CD25	83,87	CD25	CD25	3559	3559	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ cells|dep|generation cells|nmod|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15753318	0	CD25	83,87	CD25	43,47	CD25	CD25	3559	3559	Gene	Gene	cells|nmod|START_ENTITY cells|dep|generation generation|nmod|+ +|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
16146782	0	CD25	27,31	CD25	53,57	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY transduction|nmod|cells transduction|dep|END_ENTITY	Signal transduction in CD4 + CD25 + regulatory T cells : CD25 and IL-2 .
16146782	0	CD25	53,57	CD25	27,31	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	transduction|dep|START_ENTITY transduction|nmod|cells cells|compound|END_ENTITY	Signal transduction in CD4 + CD25 + regulatory T cells : CD25 and IL-2 .
17038912	0	CD25	108,112	CD25	80,84	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|nmod|START_ENTITY Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD25	80,84	CD25	108,112	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nmod|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17244157	0	CD25	5,9	CD25	60,64	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY corrected|nsubj|-LSB- corrected|ccomp|render render|dobj|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17244157	0	CD25	60,64	CD25	5,9	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	render|dobj|START_ENTITY corrected|ccomp|render corrected|nsubj|-LSB- -LSB-|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17277105	0	CD25	52,56	CD25	67,71	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17277105	0	CD25	67,71	CD25	52,56	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells END_ENTITY|dep|cells	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17875988	0	CD25	25,29	CD25	65,69	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|acl|+ +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD25	65,69	CD25	25,29	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells END_ENTITY|acl|+	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
18272926	0	CD25	31,35	CD25	54,58	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|nmod|cells cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD25	54,58	CD25	31,35	CD25	CD25	16184(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells END_ENTITY|dep|cells	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
20570629	0	CD25	132,136	CD25	81,85	CD25	CD25	3559	3559	Gene	Gene	restrain|dobj|START_ENTITY mechanisms|acl:relcl|restrain mechanisms|nmod|cell cell|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20570629	0	CD25	81,85	CD25	132,136	CD25	CD25	3559	3559	Gene	Gene	cell|compound|START_ENTITY mechanisms|nmod|cell mechanisms|acl:relcl|restrain restrain|dobj|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
21702013	0	CD25	113,117	CD25	43,47	CD25	CD25	3559	3559	Gene	Gene	Treg|compound|START_ENTITY juvenile_idiopathic_arthritis|nmod|Treg cells|amod|juvenile_idiopathic_arthritis patients|nmod|cells cells|nmod|patients suppression|dep|cells suppression|nmod|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21702013	0	CD25	43,47	CD25	113,117	CD25	CD25	3559	3559	Gene	Gene	suppression|nmod|START_ENTITY suppression|dep|cells cells|nmod|patients patients|nmod|cells cells|amod|juvenile_idiopathic_arthritis juvenile_idiopathic_arthritis|nmod|Treg Treg|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
16210336	0	CD25	93,97	CD27	67,71	CD25	CD27	3559	939	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells subset|compound|END_ENTITY	Rapamycin , and not cyclosporin_A , preserves the highly suppressive CD27 + subset of human CD4 + CD25 + regulatory T cells .
17425604	0	CD25	121,125	CD27	0,4	CD25	CD27	3559	939	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells discriminates|nmod|expansion discriminates|nsubj|expression expression|compound|END_ENTITY	CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4 + CD25 + cells .
14500627	0	CD25	58,62	CD28	14,18	CD25	CD28	16184(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY homeostasis|nmod|cells controls|dobj|homeostasis controls|nsubj|END_ENTITY	Cutting edge : CD28 controls peripheral homeostasis of CD4 + CD25 + regulatory T cells .
14609212	0	CD25	66,70	CD28	12,16	CD25	CD28	16184(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells role|nmod|END_ENTITY	The role of CD28 and CTLA4 in the function and homeostasis of CD4 + CD25 + regulatory T cells .
15016653	0	CD25	90,94	CD28	0,4	CD25	CD28	16184(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells inflammation|nmod|suppression exacerbates|dobj|inflammation exacerbates|nsubj|disruption disruption|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
16338210	0	CD25	80,84	CD28	0,4	CD25	CD28	3559	940	Gene	Gene	cells|compound|START_ENTITY put|nmod|cells put|nsubj|superagonists superagonists|compound|END_ENTITY	CD28 superagonists put a break on autoimmunity by preferentially activating CD4 + CD25 + regulatory T cells .
16699464	0	CD25	66,70	CD28	119,123	CD25	CD28	3559	940	Gene	Gene	START_ENTITY|acl|bypassing bypassing|dobj|costimulation costimulation|compound|END_ENTITY	A divalent human leukocyte antigen-B7 fusion-protein up-regulates CD25 and CD69 in alloreactive CD8 + T cells bypassing CD28 costimulation .
17038912	0	CD25	108,112	CD28	15,19	CD25	CD28	16184(Tax:10090)	12487(Tax:10090)	Gene	Gene	Tregs|nmod|START_ENTITY converted|dobj|Tregs converted|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD25	80,84	CD28	15,19	CD25	CD28	16184(Tax:10090)	12487(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY converted|dobj|Tregs converted|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
18780874	0	CD25	42,46	CD28	36,40	CD25	CD28	3559	940	Gene	Gene	lymphocytes|nummod|START_ENTITY frequency|dep|lymphocytes frequency|nmod|END_ENTITY	The frequency of regulatory CD3 + CD8 + CD28 - CD25 + T lymphocytes in human peripheral blood increases with age .
19949106	0	CD25	6,10	CD28	56,60	CD25	CD28	3559	940	Gene	Gene	regulatory|nsubj|START_ENTITY regulatory|ccomp|resist resist|dobj|form form|nmod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells resist a novel form of CD28 - and Fas-dependent p53-induced T cell apoptosis .
9176107	0	CD25	148,152	CD3	137,140	CD25	CD3	16184(Tax:10090)	12503(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
19427686	0	CD25	4,8	CD39	83,87	CD25	CD39	16184(Tax:10090)	12495(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|suppress suppress|nmod|END_ENTITY	CD4 + CD25 + regulatory T cells suppress contact_hypersensitivity reactions through a CD39 , adenosine-dependent mechanism .
20977632	0	CD25	50,54	CD39	14,18	CD25	CD39	3559	953	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression of CD39 by human peripheral blood CD4 + CD25 + T cells denotes a regulatory memory phenotype .
24752698	0	CD25	30,34	CD39	47,51	CD25	CD39	3669	953	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
26467610	0	CD25	90,94	CD39	135,139	CD25	CD39	3669	953	Gene	Gene	subsets|nmod|START_ENTITY subsets|dobj|cells cells|acl|identified identified|nmod|expression expression|nmod|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
10200133	0	CD25	38,42	CD4	47,50	CD25	CD4	3559	920	Gene	Gene	receptor|appos|START_ENTITY Expression|nmod|receptor Expression|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Expression of interleukin-2 receptor , CD25 , on CD4 lymphocytes in response_to_varicella-zoster_virus antigen among patients with malignancies immunized with live attenuated varicella vaccine .
10553041	0	CD25	40,44	CD4	45,48	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Induction of tumor immunity by removing CD25 + CD4 + T cells : a common basis between tumor immunity and autoimmunity .
10605010	0	CD25	36,40	CD4	32,35	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppressor effector function of CD4 + CD25 + immunoregulatory T cells is antigen nonspecific .
10795741	0	CD25	66,70	CD4	62,65	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	B7/CD28 costimulation is essential for the homeostasis of the CD4 + CD25 + immunoregulatory T cells that control autoimmune diabetes .
10975823	0	CD25	0,4	CD4	21,24	CD25	CD4	3559	24932(Tax:10116)	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|thymocytes thymocytes|nummod|END_ENTITY	CD25 is a marker for CD4 + thymocytes that prevent autoimmune_diabetes in rats , but peripheral T cells with this function are found in both CD25 + and CD25 - subpopulations .
11182148	0	CD25	103,107	CD4	39,42	CD25	CD4	396814(Tax:9823)	404704(Tax:9823)	Gene	Gene	phenotype|compound|START_ENTITY lymphoblastoid|nmod|phenotype characterization|parataxis|lymphoblastoid characterization|nmod|END_ENTITY	Functional characterization of a swine CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- double positive lymphoblastoid T-cell line with a CD25 -LRB- + -RRB- / CD45RA -LRB- - -RRB- phenotype generated in vitro with interleukin-2 .
11207250	0	CD25	0,4	CD4	56,59	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY +|nsubj|CD4 +|ccomp|regulate regulate|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11390462	0	CD25	93,97	CD4	89,92	CD25	CD4	3559	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Tolerance to cyclosporin_A-induced autologous graft-versus-host disease is mediated by a CD4 + CD25 + subset of recent thymic emigrants .
11466326	0	CD25	55,59	CD4	51,54	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : control of CD8 + T cell activation by CD4 + CD25 + immunoregulatory cells .
11488983	0	CD25	22,26	CD4	28,31	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY +|nmod|induction +|nsubj|END_ENTITY	In vitro induction of CD25 + CD4 + regulatory T cells by the neuropeptide alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- .
11564442	0	CD25	42,46	CD4	19,22	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|compound|END_ENTITY	Natural regulatory CD4 T cells expressing CD25 .
11696203	0	CD25	60,64	CD4	52,55	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	TCRbeta|compound|START_ENTITY TCRbeta|compound|END_ENTITY	CD8 + T cells induce medullary thymic epithelium and CD4 + CD8 + CD25 + TCRbeta - thymocytes in SCID mice .
11722621	0	CD25	36,40	CD4	42,45	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells : their common role in controlling autoimmunity , tumor immunity , and transplantation tolerance .
11722623	0	CD25	37,41	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Control of T-cell activation by CD4 + CD25 + suppressor T cells .
11890298	0	CD25	105,109	CD4	101,104	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased total numbers of peripheral blood lymphocytes with elevated percentages of CD4 + CD45RO + and CD4 + CD25 + of T-helper cells in non-segmental_vitiligo .
11981815	0	CD25	0,4	CD4	38,41	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY +|nsubj|CD4 +|ccomp|suppress suppress|xcomp|hyperinflammation hyperinflammation|nsubj|T T|compound|END_ENTITY	CD25 + CD4 + regulatory T cells suppress CD4 + T cell-mediated pulmonary hyperinflammation driven by Pneumocystis_carinii in immunodeficient mice .
11981815	7	CD25	1058,1062	CD4	1065,1068	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	In contrast , transfer of CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- cells did not induce lethal pneumonia and prevented the development of the disease induced by CD25 -LRB- - -RRB- CD4 -LRB- + -RRB- cells .
12000861	0	CD25	8,12	CD4	3,6	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Do CD4 + CD25 + immunoregulatory T cells hinder tumor immunotherapy ?
12000862	0	CD25	18,22	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory cells augments the generation of specific immune T cells in tumor-draining lymph_nodes .
12028564	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12028564	0	CD25	4,8	CD4	71,74	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|ccomp|suppress suppress|dobj|proliferation proliferation|nmod|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12028564	0	CD25	75,79	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	proliferation|nmod|START_ENTITY suppress|dobj|proliferation lymphocytes|ccomp|suppress lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12047748	0	CD25	26,30	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of human CD25 + CD4 + T cells in thymus , cord and adult blood .
12055202	0	CD25	31,35	CD4	27,30	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : depletion of CD4 + CD25 + regulatory T cells is necessary , but not sufficient , for induction of organ-specific autoimmune_disease .
12060392	0	CD25	66,70	CD4	59,62	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Transient CD44 variant isoform expression and reduction in CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- regulatory T cells in C3H/HeJ mice with alopecia areata .
12087082	0	CD25	48,52	CD4	91,94	CD25	CD4	3559	920	Gene	Gene	interleukin-2_receptor_alpha|appos|START_ENTITY Expression|nmod|interleukin-2_receptor_alpha decreased|nsubjpass|Expression decreased|nmod|+ +|compound|END_ENTITY	Expression of the interleukin-2_receptor_alpha -LRB- CD25 -RRB- is selectively decreased on decidual CD4 + and CD8 + T lymphocytes in normal pregnancies .
12093005	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + suppressor T cells : more questions than answers .
12119350	0	CD25	28,32	CD4	98,101	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|acl:relcl|convey convey|xcomp|cells cells|nsubj|activity activity|nmod|T T|compound|END_ENTITY	Infectious tolerance : human CD25 -LRB- + -RRB- regulatory T cells convey suppressor activity to conventional CD4 -LRB- + -RRB- T helper cells .
12163566	0	CD25	63,67	CD4	57,60	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|nsubj|Phenotype Phenotype|nmod|suppression suppression|nmod|END_ENTITY	Phenotype , localization , and mechanism of suppression of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- human thymocytes .
12193715	0	CD25	25,29	CD4	21,24	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
12200381	0	CD25	133,137	CD4	126,129	CD25	CD4	3559	920	Gene	Gene	T|nsubj|START_ENTITY effects|parataxis|T effects|dep|characterization characterization|nmod|subset subset|nmod|END_ENTITY	Long-term effects of intermittent interleukin_2 therapy in patients with HIV_infection : characterization of a novel subset of CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- T cells .
12218142	0	CD25	171,175	CD4	167,170	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The early IL-4 response to Leishmania_major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 + CD25 + T cells .
12234995	0	CD25	70,74	CD4	65,68	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY mediated|nsubjpass|cells Inhibition|parataxis|mediated Inhibition|nmod|+ +|compound|END_ENTITY	Inhibition of cytolytic T lymphocyte proliferation by autologous CD4 + / CD25 + regulatory T cells in a colorectal_carcinoma patient is mediated by transforming_growth_factor-beta .
12406391	0	CD25	16,20	CD4	12,15	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The role of CD4 + CD25 + immunoregulatory T cells in the induction of autoimmune_gastritis .
12421913	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : CD4 + CD25 + alloantigen-specific immunoregulatory cells that can prevent CD8 + T cell-mediated graft rejection : implications for anti-CD154 immunotherapy .
12438424	0	CD25	6,10	CD4	11,14	CD25	CD4	3559	920	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Human CD25 + CD4 + T suppressor cell clones produce transforming_growth_factor_beta , but not interleukin_10 , and are distinct from type 1 T regulatory cells .
12444136	0	CD25	22,26	CD4	18,21	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	B7/CD28-dependent CD4 + CD25 + regulatory T cells are essential components of the memory-protective immunity to Candida_albicans .
12466842	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control Leishmania_major persistence and immunity .
12496410	0	CD25	0,4	CD4	23,26	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY immunoregulatory|nsubj|+ immunoregulatory|ccomp|mediate mediate|nsubj|cells cells|compound|END_ENTITY	CD25 + immunoregulatory CD4 T cells mediate acquired central transplantation tolerance .
12515818	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD25 + T -LRB- R -RRB- cells suppress innate immune pathology through cytokine-dependent mechanisms .
12547727	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + regulatory T lymphocytes inhibit microbially induced colon_cancer in Rag2-deficient mice .
12594277	0	CD25	4,8	CD4	82,85	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|acl:relcl|express express|ccomp|suppress suppress|dobj|colitis colitis|nummod|END_ENTITY	CD4 + CD25 - T cells that express latency-associated_peptide on the surface suppress CD4 + CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism .
12612578	0	CD25	51,55	CD4	47,50	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells .
12612581	0	CD25	37,41	CD4	33,36	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	An essential role for Scurfin in CD4 + CD25 + T regulatory cells .
12645292	0	CD25	7,11	CD4	1,4	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY T-lymphocytes|nummod|+ +|appos|T-lymphocytes +|compound|END_ENTITY	-LSB- CD4 + , CD25 + regulatory T-lymphocytes : current concepts and therapeutic potential -RSB- .
12651220	0	CD25	34,38	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	immunosuppression|compound|START_ENTITY immunosuppression|compound|END_ENTITY	TGF-beta : the missing link in CD4 + CD25 + regulatory T cell-mediated immunosuppression .
12663682	0	CD25	22,26	CD4	18,21	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Antigen-specific , CD4 + CD25 + regulatory T cell clones induced in Peyer 's patches .
12718754	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + immunoregulatory T cells may not be involved in controlling autoimmune_arthritis .
12731049	0	CD25	22,26	CD4	18,21	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Idiotype-specific CD4 + CD25 + T suppressor cells prevent , by limiting antibody diversity , the occurrence of anti-dextran antibodies crossreacting with histone H3 .
12734345	0	CD25	122,126	CD4	118,121	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4 + CD25 + regulatory T cells in vivo .
12743364	0	CD25	94,98	CD4	122,125	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25 - and CTLA-4-expressing CD4 + T cells .
12750357	0	CD25	45,49	CD4	123,126	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|acl:relcl|transfer transfer|nmod|cells cells|compound|END_ENTITY	Nasal tolerance induces antigen-specific CD4 + CD25 - regulatory T cells that can transfer their regulatory capacity to naive CD4 + T cells .
12759427	0	CD25	5,9	CD4	10,13	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial_hyperreactivity .
12761268	0	CD25	4,8	CD4	0,3	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients .
12810075	0	CD25	53,57	CD4	86,89	CD25	CD4	3559	920	Gene	Gene	gene|nmod|START_ENTITY expressions|nmod|gene expressions|dep|subsets subsets|nmod|cells cells|compound|END_ENTITY	Differential expressions of heme_oxygenase-1 gene in CD25 - and CD25 + subsets of human CD4 + T cells .
12810075	0	CD25	63,67	CD4	86,89	CD25	CD4	3559	920	Gene	Gene	subsets|nummod|START_ENTITY subsets|nmod|cells cells|compound|END_ENTITY	Differential expressions of heme_oxygenase-1 gene in CD25 - and CD25 + subsets of human CD4 + T cells .
12847237	0	CD25	51,55	CD4	67,70	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY inflammatory_bowel_disease|nmod|+ Regulation|nmod|inflammatory_bowel_disease Regulation|dep|+ +|compound|END_ENTITY	Regulation of murine inflammatory_bowel_disease by CD25 + and CD25 - CD4 + glucocorticoid-induced TNF receptor family-related gene + regulatory T cells .
12855551	0	CD25	11,15	CD4	7,10	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Innate CD4 + CD25 + regulatory T cells are required for oral tolerance and inhibition of CD8 + T cells mediating skin_inflammation .
12874259	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo .
12893750	0	CD25	77,81	CD4	73,76	CD25	CD4	3559	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Human CD8 + CD25 + thymocytes share phenotypic and functional features with CD4 + CD25 + regulatory thymocytes .
12893754	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells inhibit immune-mediated transgene rejection .
12907445	0	CD25	0,4	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	CD25 expression on donor CD4 + or CD8 + T cells is associated with an increased risk for graft-versus-host_disease after HLA-identical stem cell transplantation in humans .
12923427	0	CD25	75,79	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Pretransplant blood transfusion without additional immunotherapy generates CD25 + CD4 + regulatory T cells : a potential explanation for the blood-transfusion effect .
12928371	0	CD25	45,49	CD4	41,44	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY populations|compound|END_ENTITY	Systemic overexpression of IL-10 induces CD4 + CD25 + cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion .
12941137	0	CD25	0,4	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	CD25 + , interleukin-10-producing CD4 + T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye .
12947044	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T cells responding to serologically defined autoantigens suppress antitumor immune responses .
12949259	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells control anti-islet CD8 + T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes .
12967782	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	mediate|compound|START_ENTITY mediate|compound|END_ENTITY	CD4 + CD25 + regulatory T cells mediate acquired transplant tolerance .
14500627	0	CD25	58,62	CD4	54,57	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : CD28 controls peripheral homeostasis of CD4 + CD25 + regulatory T cells .
14500643	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + and CD4 + CD25 - T cells act respectively as inducer and effector T suppressor cells in superantigen-induced tolerance .
14515359	0	CD25	31,35	CD4	27,30	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional assay for human CD4 + CD25 + Treg cells reveals an age-dependent loss of suppressive activity .
14519757	0	CD25	97,101	CD4	92,95	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4 + CD25 + and CD8 + regulatory T cell subsets .
14522933	0	CD25	6,10	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|amod|START_ENTITY require|nsubj|lymphocytes require|nsubj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory lymphocytes require interleukin_10 to interrupt colon_carcinogenesis in mice .
14568934	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + CD25 + T cells lyse antigen-presenting B cells by Fas-Fas ligand interaction in an epitope-specific manner .
14609209	0	CD25	35,39	CD4	40,43	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Thymic generation and selection of CD25 + CD4 + regulatory T cells : implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance .
14609210	0	CD25	36,40	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Control of T cell activation by CD4 + CD25 + suppressor T cells .
14609212	0	CD25	66,70	CD4	62,65	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The role of CD28 and CTLA4 in the function and homeostasis of CD4 + CD25 + regulatory T cells .
14609213	0	CD25	83,87	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	vivo|compound|START_ENTITY levels|nmod|vivo express|dobj|levels express|nsubj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + regulatory cells from human peripheral blood express very high levels of CD25 ex vivo .
14609215	0	CD25	58,62	CD4	54,57	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Type 1 T regulatory cells and their relationship with CD4 + CD25 + T regulatory cells .
14632657	1	CD25	65,69	CD4	60,63	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations in CD4 + CD25 + T regulatory cell phenotype and T-cell receptor Vbeta repertoire .
14676299	0	CD25	29,33	CD4	52,55	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|dep|cells cells|nmod|CD25 CD25|compound|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	CD25	56,60	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY Conversion|dep|cells Conversion|nmod|CD25 CD25|compound|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14678036	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD4 + CD25 + CD62 + T-regulatory cell subset has optimal suppressive and proliferative potential .
14679076	0	CD25	57,61	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Difference in gene expression profiles between human CD4 + CD25 + and CD4 + CD25 - T cells .
14699080	0	CD25	29,33	CD4	24,27	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Impaired development of CD4 + CD25 + regulatory T cells in the absence of STAT1 : increased susceptibility to autoimmune_disease .
14707048	0	CD25	41,45	CD4	37,40	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD7 and CD28 are required for murine CD4 + CD25 + regulatory T cell homeostasis and prevention of thyroiditis .
14707053	0	CD25	59,63	CD4	55,58	CD25	CD4	3559	920	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	TGF-beta_1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice .
14707064	0	CD25	20,24	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Alloantigen-induced CD25 + CD4 + regulatory T cells can develop in vivo from CD25-CD4 + precursors in a thymus-independent process .
14734610	0	CD25	85,89	CD4	90,93	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-10 is involved in the suppression of experimental_autoimmune_encephalomyelitis by CD25 + CD4 + regulatory T cells .
14734622	0	CD25	46,50	CD4	42,45	CD25	CD4	3559	24932(Tax:10116)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic characterization of regulatory CD4 + CD25 + T cells in rats .
14744995	0	CD25	85,89	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Massive thymic deletion results in systemic autoimmunity through elimination of CD4 + CD25 + T regulatory cells .
14768041	0	CD25	49,53	CD4	45,48	CD25	CD4	3559	920	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Activation requirements for the induction of CD4 + CD25 + T cell suppressor function .
14871297	0	CD25	14,18	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|END_ENTITY	Decreased CD4 + CD25 + T cells in peripheral blood of patients with systemic_lupus_erythematosus .
14963140	0	CD25	11,15	CD4	6,9	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens .
14979928	0	CD25	29,33	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A paragon of self-tolerance : CD25 + CD4 + regulatory T cells and the control of immune responses .
14991599	0	CD25	143,147	CD4	139,142	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991599	0	CD25	143,147	CD4	54,57	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY counter-regulated|nmod|cells cells|acl:relcl|counter-regulated Demonstration|dep|cells Demonstration|nmod|reactivity reactivity|nmod|CD25 CD25|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991599	0	CD25	58,62	CD4	139,142	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	reactivity|nmod|START_ENTITY Demonstration|nmod|reactivity Demonstration|dep|cells cells|acl:relcl|counter-regulated counter-regulated|nmod|cells cells|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991600	0	CD25	25,29	CD4	31,34	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	MHC class II-independent CD25 + CD4 + CD8alpha beta + alpha beta T cells attenuate CD4 + T cell-induced transfer colitis .
14991600	0	CD25	25,29	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	MHC class II-independent CD25 + CD4 + CD8alpha beta + alpha beta T cells attenuate CD4 + T cell-induced transfer colitis .
14991616	0	CD25	36,40	CD4	32,35	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Differential response of murine CD4 + CD25 + and CD4 + CD25 - T cells to dexamethasone-induced cell death .
15016653	0	CD25	90,94	CD4	86,89	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15021844	0	CD25	15,19	CD4	11,14	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + T cells in the peripheral blood of lung transplant recipients : correlation with transplant outcome .
15024182	0	CD25	16,20	CD4	12,15	CD25	CD4	3669	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Circulating CD4 + CD25 + T regulatory cells are not altered in multiple_sclerosis and unaffected by disease-modulating drugs .
15027897	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg : divide and rule ?
15034024	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the severity of viral_immunoinflammatory_lesions .
15036231	0	CD25	24,28	CD4	20,23	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naturally-occurring CD4 + CD25 + immunoregulatory T cells : central players in the arena of peripheral tolerance .
15049785	0	CD25	16,20	CD4	12,15	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CD4 + CD25 + and CD4 + CD25 + T cells in myasthenia_gravis and in relation to thymectomy .
15067041	0	CD25	24,28	CD4	20,23	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : human CD4 + CD25 + T cells restrain the maturation and antigen-presenting function of dendritic cells .
15067051	0	CD25	104,108	CD4	100,103	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Feline_immunodeficiency_virus_infection phenotypically and functionally activates immunosuppressive CD4 + CD25 + T regulatory cells .
15096182	0	CD25	81,85	CD4	87,90	CD25	CD4	3559	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Normal human pregnancy is associated with an elevation in the immune suppressive CD25 + CD4 + regulatory T-cell subset .
15100259	0	CD25	24,28	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|educate educate|dobj|CD25 CD25|compound|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15100259	0	CD25	48,52	CD4	20,23	CD25	CD4	3559	920	Gene	Gene	educate|dobj|START_ENTITY +|ccomp|educate +|nsubj|CD25 CD25|compound|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15100684	13	CD25	1823,1827	CD4	1819,1822	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	In contrast , after SEB stimulation , CD4 + CD25 + cells were no longer anergic .
15111929	0	CD25	0,4	CD4	65,68	CD25	CD4	3559	920	Gene	Gene	distinguishes|compound|START_ENTITY subsets|nsubj|distinguishes subsets|nsubj|T-cell T-cell|compound|END_ENTITY	CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 -LRB- OX40 -RRB- T-cell subsets in acute_graft-versus-host_disease .
15119549	0	CD25	20,24	CD4	16,19	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A deficiency of CD4 + CD25 + T cells permits the development of spontaneous_lupus-like_disease in mice , and can be reversed by induction of mucosal tolerance to histone peptide autoantigen .
15136590	0	CD25	149,153	CD4	144,147	CD25	CD4	3559	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Increased expression of human T lymphocyte virus type I -LRB- HTLV-I -RRB- Tax11-19 peptide-human histocompatibility leukocyte antigen A * 201 complexes on CD4 + CD25 + T Cells detected by peptide-specific , major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic_disease .
15153463	0	CD25	77,81	CD4	73,76	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Cutting edge : IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function .
15161853	0	CD25	45,49	CD4	52,55	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	self-antigens|nmod|START_ENTITY responses|nmod|self-antigens END_ENTITY|nsubj|responses	Immune responses to retinal self-antigens in CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T-cell-depleted mice .
15184500	0	CD25	0,4	CD4	6,9	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD25 + CD4 + T cells , expanded with dendritic cells presenting a single autoantigenic peptide , suppress autoimmune diabetes .
15184501	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic_lesion .
15185013	0	CD25	50,54	CD4	46,49	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dendritic_cells reduce number and function of CD4 + CD25 + cells in cytokine-induced killer cells derived from patients with pancreatic_carcinoma .
15187106	0	CD25	79,83	CD4	96,99	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Costimulation via glucocorticoid-induced_TNF_receptor in both conventional and CD25 + regulatory CD4 + T cells .
15240694	0	CD25	18,22	CD4	14,17	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Resistance to CD4 + CD25 + regulatory T cells and TGF-beta in Cbl-b - / - mice .
15240714	0	CD25	0,4	CD4	5,8	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15240805	0	CD25	87,91	CD4	83,86	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dopamine , through the extracellular signal-regulated kinase pathway , downregulates CD4 + CD25 + regulatory T-cell activity : implications for neurodegeneration .
15271794	0	CD25	53,57	CD4	107,110	CD25	CD4	3559	920	Gene	Gene	expansion|nmod|START_ENTITY +|nsubj|expansion +|dobj|cells cells|acl:relcl|suppress suppress|dobj|responses responses|compound|END_ENTITY	Human_immunodeficiency virus-driven expansion of CD4 + CD25 + regulatory T cells , which suppress HIV-specific CD4 T-cell responses in HIV-infected patients .
15294932	0	CD25	51,55	CD4	47,50	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	compartment|compound|START_ENTITY compartment|compound|END_ENTITY	Cutting edge : estrogen drives expansion of the CD4 + CD25 + regulatory T cell compartment .
15295006	0	CD25	39,43	CD4	35,38	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Targeted CTLA-4 engagement induces CD4 + CD25 + CTLA-4high T regulatory cells with target -LRB- allo -RRB- antigen specificity .
15298560	0	CD25	101,105	CD4	96,99	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction of T ` regulatory ' cells by standardized house dust mite immunotherapy : an increase in CD4 + CD25 + interleukin-10 + T cells expressing peripheral tissue trafficking markers .
15307180	0	CD25	35,39	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Interleukin-2 is essential for CD4 + CD25 + regulatory T cell function .
15308106	0	CD25	56,60	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	receptors|nummod|START_ENTITY receptors|compound|END_ENTITY	Recognition of the peripheral self by naturally arising CD25 + CD4 + T cell receptors .
15322152	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + cells controlling a pathogenic CD4 response inhibit cytokine differentiation , CXCR-3 expression , and tissue invasion .
15322152	0	CD25	4,8	CD4	41,44	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|acl|controlling controlling|dobj|response response|compound|END_ENTITY	CD4 + CD25 + cells controlling a pathogenic CD4 response inhibit cytokine differentiation , CXCR-3 expression , and tissue invasion .
15322168	0	CD25	29,33	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional maturation of CD4 + CD25 + CTLA4 + CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens .
15331781	0	CD25	19,23	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dual effect of CD4 + CD25 + regulatory T cells in neurodegeneration : a dialogue with microglia .
15376196	0	CD25	24,28	CD4	20,23	CD25	CD4	3669	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of a CD4 + CD25 + T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation .
15383574	0	CD25	103,107	CD4	99,102	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4 + CD25 + regulatory T cells .
15456701	0	CD25	109,113	CD4	105,108	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4 + CD25 + regulatory T cells to rescue abortion-prone fetuses .
15466453	0	CD25	63,67	CD4	68,71	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Crucial role of FOXP3 in the development and function of human CD25 + CD4 + regulatory T cells .
15470042	0	CD25	11,15	CD4	7,10	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine CD4 + CD25 + regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene .
15470044	0	CD25	142,146	CD4	138,141	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Engagement of glucocorticoid-induced_TNFR_family-related_receptor on effector T cells by its ligand mediates resistance to suppression by CD4 + CD25 + T cells .
15479730	0	CD25	80,84	CD4	85,88	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25 + CD4 + Tr cells .
15505606	0	CD25	30,34	CD4	26,29	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Tracking ex vivo-expanded CD4 + CD25 + and CD8 + CD25 + regulatory T cells after infusion to prevent donor lymphocyte infusion-induced lethal acute_graft-versus-host_disease .
15520045	0	CD25	18,22	CD4	23,26	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Control of Foxp3 + CD25 + CD4 + regulatory cell activation and function by dendritic cells .
15528313	0	CD25	66,70	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Immunotherapy of autoimmune encephalomyelitis with redirected CD4 + CD25 + T lymphocytes .
15539509	0	CD25	20,24	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Association of CD4 + CD25 + T cells with prevention of severe destructive_arthritis in Borrelia_burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody .
15546950	0	CD25	37,41	CD4	33,36	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Only the CD62L + subpopulation of CD4 + CD25 + regulatory T cells protects from lethal acute GVHD .
15556680	0	CD25	121,125	CD4	117,120	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Overlap between molecular markers expressed by naturally occurring CD4 + CD25 + regulatory T cells and antigen specific CD4 + CD25 + and CD8 + CD28 - T_suppressor cells .
15556680	0	CD25	71,75	CD4	67,70	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Overlap between molecular markers expressed by naturally occurring CD4 + CD25 + regulatory T cells and antigen specific CD4 + CD25 + and CD8 + CD28 - T_suppressor cells .
15585928	0	CD25	81,85	CD4	77,80	CD25	CD4	3559	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Regulatory T-cells in antitumor therapy : isolation and functional testing of CD4 + CD25 + regulatory T-cells .
15601314	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory T cells : I. Phenotype and physiology .
15611231	0	CD25	119,123	CD4	115,118	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4 + CD25 + regulatory T cells .
15611472	0	CD25	26,30	CD4	34,37	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Impaired up-regulation of CD25 on CD4 + T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart_failure .
15620457	0	CD25	48,52	CD4	44,47	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression of FOXP3 mRNA is not confined to CD4 + CD25 + T regulatory cells in humans .
15630140	0	CD25	19,23	CD4	36,39	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|dep|cells cells|nmod|+ +|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15630140	0	CD25	41,45	CD4	14,17	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ Conversion|dep|cells Conversion|nmod|CD25 CD25|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15630140	0	CD25	41,45	CD4	36,39	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15637139	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	24932(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control induction of autoimmune_hemolytic_anemia .
15640650	0	CD25	103,107	CD4	24,27	CD25	CD4	3669	920	Gene	Gene	decrease|nmod|START_ENTITY due|nmod|decrease due|nsubj|percentage percentage|nmod|CD25 CD25|compound|END_ENTITY	Increased percentage of CD4 + CD25 + regulatory T cells during septic_shock is due to the decrease of CD4 + CD25 - lymphocytes .
15640650	0	CD25	28,32	CD4	99,102	CD25	CD4	3669	920	Gene	Gene	percentage|nmod|START_ENTITY due|nsubj|percentage due|nmod|decrease decrease|nmod|CD25 CD25|compound|END_ENTITY	Increased percentage of CD4 + CD25 + regulatory T cells during septic_shock is due to the decrease of CD4 + CD25 - lymphocytes .
15649266	0	CD25	67,71	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15649266	0	CD25	67,71	CD4	74,77	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY recruitment|nmod|+ induces|dobj|recruitment induces|parataxis|+ +|nsubj|interferon-gamma interferon-gamma|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15657288	0	CD25	105,109	CD4	100,103	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4 + T lymphocytes by CD4 + CD25 + regulatory T cells .
15657288	0	CD25	105,109	CD4	78,81	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY play|nmod|cells play|dobj|role role|nmod|suppression suppression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4 + T lymphocytes by CD4 + CD25 + regulatory T cells .
15668741	0	CD25	40,44	CD4	36,39	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The IL-6R_alpha chain controls lung CD4 + CD25 + Treg development and function during allergic airway inflammation in vivo .
15677327	0	CD25	92,96	CD4	88,91	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Down-regulation of myasthenogenic T cell responses by a dual altered peptide ligand via CD4 + CD25 + - regulated events leading to apoptosis .
15679891	0	CD25	19,23	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The changes of CD4 + CD25 + / CD4 + proportion in spleen of tumor-bearing BALB/c mice .
15679891	0	CD25	19,23	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY changes|nmod|+ changes|dep|proportion proportion|nummod|END_ENTITY	The changes of CD4 + CD25 + / CD4 + proportion in spleen of tumor-bearing BALB/c mice .
15682445	0	CD25	37,41	CD4	33,36	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	homeostasis|compound|START_ENTITY homeostasis|nummod|END_ENTITY	CD40/CD40L interaction regulates CD4 + CD25 + T reg homeostasis through dendritic cell-produced IL-2 .
15684039	0	CD25	0,4	CD4	38,41	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY +|nsubj|CD4 +|ccomp|compete compete|nmod|cells cells|compound|END_ENTITY	CD25 + CD4 + T cells compete with naive CD4 + T cells for IL-2 and exploit it for the induction of IL-10 production .
15693142	0	CD25	166,170	CD4	161,164	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Large intestine intraepithelial lymphocytes from Apc + / + and Apc + / Min mice and their modulation by indigestible carbohydrates : the IL-15 / IL-15R_alpha complex and CD4 + CD25 + T cells are the main targets .
15699103	0	CD25	50,54	CD4	46,49	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : contact-mediated suppression by CD4 + CD25 + regulatory cells involves a granzyme_B-dependent , perforin-independent mechanism .
15699124	0	CD25	59,63	CD4	55,58	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCR8 is expressed by antigen-elicited , IL-10-producing CD4 + CD25 + T cells , which regulate Th2-mediated granuloma formation in mice .
15707399	0	CD25	59,63	CD4	55,58	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Everolimus and basiliximab permit suppression by human CD4 + CD25 + cells in vitro .
15710910	0	CD25	81,85	CD4	47,50	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY response|nmod|cells response|compound|END_ENTITY	A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25 + CD4 T cells in vivo .
15710910	0	CD25	81,85	CD4	86,89	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25 + CD4 T cells in vivo .
15713793	0	CD25	0,4	CD4	5,8	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD25 + CD4 + regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection : antigen-specific reactivation in vivo is critical for bystander regulation .
15725955	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells , immunotherapy of cancer , and interleukin-2 .
15728475	0	CD25	47,51	CD4	43,46	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD25	47,51	CD4	73,76	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|nmod|CD25 CD25|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD25	77,81	CD4	43,46	CD25	CD4	3559	920	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728508	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control innate immune reactivity after injury .
15729177	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Augmented induction of CD4 + CD25 + Treg using monoclonal antibodies to CD200R .
15731180	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	regulatory/suppressor|compound|START_ENTITY regulatory/suppressor|compound|END_ENTITY	Ontogeny of CD4 + CD25 + regulatory/suppressor T cells in human fetuses .
15743476	0	CD25	141,145	CD4	137,140	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	The role of regulatory T cells in antigen-induced arthritis : aggravation of arthritis after depletion and amelioration after transfer of CD4 + CD25 + T cells .
15743488	0	CD25	14,18	CD4	10,13	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	functioning|compound|START_ENTITY functioning|compound|END_ENTITY	Defective CD4 + CD25 + regulatory T cell functioning in collagen-induced_arthritis : an important factor in pathogenesis , counter-regulated by endogenous IFN-gamma .
15746082	0	CD25	34,38	CD4	30,33	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Rapamycin selectively expands CD4 + CD25 + FoxP3 + regulatory T cells .
15749914	0	CD25	136,140	CD4	131,134	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4 + CD25 + T cells .
15752557	0	CD25	50,54	CD4	46,49	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cure of innate intestinal immune pathology by CD4 + CD25 + regulatory T cells .
15753306	0	CD25	7,11	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|constitute constitute|nsubj|cells cells|compound|END_ENTITY	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15753306	0	CD25	90,94	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regain|dobj|expression reservoir|acl:relcl|regain constitute|dobj|reservoir constitute|nsubj|cells cells|compound|END_ENTITY	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15753318	0	CD25	43,47	CD4	39,42	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15753318	0	CD25	43,47	CD4	79,82	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ cells|dep|generation cells|nmod|CD25 CD25|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15753318	0	CD25	83,87	CD4	39,42	CD25	CD4	3559	920	Gene	Gene	cells|nmod|START_ENTITY cells|dep|generation generation|nmod|+ +|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15770696	0	CD25	83,87	CD4	79,82	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD1d-restricted natural killer T cells secrete IL-2 : innate help for CD4 + CD25 + regulatory T cells ?
15784460	0	CD25	56,60	CD4	52,55	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Modulation of monocyte/macrophage function by human CD4 + CD25 + regulatory T cells .
15788479	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice .
15795282	0	CD25	67,71	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	correlates|compound|START_ENTITY correlates|compound|END_ENTITY	Preferential feline_immunodeficiency_virus _ -LRB- FIV -RRB- infection of CD4 + CD25 + T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors .
15807863	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid_arthritis .
15818683	0	CD25	12,16	CD4	69,72	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD4|nummod|START_ENTITY CD4|parataxis|show show|dobj|sensitivity sensitivity|nmod|suppression suppression|nmod|END_ENTITY	MRL/Mp CD4 + , CD25 - T cells show reduced sensitivity to suppression by CD4 + , CD25 + regulatory T cells in vitro : a novel defect of T cell regulation in systemic_lupus_erythematosus .
15818683	0	CD25	74,78	CD4	7,10	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD4|nummod|START_ENTITY suppression|nmod|CD4 sensitivity|nmod|suppression show|dobj|sensitivity END_ENTITY|parataxis|show	MRL/Mp CD4 + , CD25 - T cells show reduced sensitivity to suppression by CD4 + , CD25 + regulatory T cells in vitro : a novel defect of T cell regulation in systemic_lupus_erythematosus .
15837218	0	CD25	22,26	CD4	16,19	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Peptide induces CD4 -LRB- + -RRB- CD25 + and IL-10 + T cells and protection in airway allergy models .
15837817	0	CD25	74,78	CD4	70,73	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes .
15840520	0	CD25	72,76	CD4	68,71	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Different thresholds of T cell activation regulate FIV_infection of CD4 + CD25 + and CD4 + CD25 - cells .
15840697	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients .
15840697	0	CD25	5,9	CD4	72,75	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY control|nsubj|cells control|dobj|induction induction|nmod|responses responses|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients .
15843512	0	CD25	101,105	CD4	97,100	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	An integral role for heme_oxygenase-1 and carbon_monoxide in maintaining peripheral tolerance by CD4 + CD25 + regulatory T cells .
15845645	0	CD25	26,30	CD4	22,25	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	BALB/c mice have more CD4 + CD25 + T regulatory cells and show greater susceptibility to suppression of their CD4 + CD25 - responder T cells than C57BL/6 mice .
15848666	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decrease of CD4 + CD25 + T cells in peripheral blood after liver transplantation : association with immunosuppression .
15853744	0	CD25	129,133	CD4	125,128	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TCR peptide vaccination in multiple_sclerosis : boosting a deficient natural regulatory network that may involve TCR-specific CD4 + CD25 + Treg cells .
15854035	0	CD25	126,130	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|induces induces|dobj|END_ENTITY	Transfer of CD8 -LRB- + -RRB- cells induces localized hair loss whereas CD4 -LRB- + -RRB- / CD25 -LRB- - -RRB- cells promote systemic alopecia areata and CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- cells blockade disease onset in the C3H/HeJ mouse model .
15870014	0	CD25	28,32	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	In vitro expanded human CD4 + CD25 + regulatory T cells suppress effector T cell proliferation .
15870015	0	CD25	90,94	CD4	85,88	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Functional analysis of highly defined , FACS-isolated populations of human regulatory CD4 + CD25 + T cells .
15879088	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells attenuate the phosphatidylinositol 3-kinase/Akt pathway in antigen-primed immature CD8 + CTLs during functional maturation .
15880066	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Augmented Induction of CD4 + CD25 + Treg using monoclonal antibodies to CD200R .
15899580	0	CD25	70,74	CD4	76,79	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cyclophosphamide decreases the number , percentage and the function of CD25 + CD4 + regulatory T cells , which suppress induction of contact_hypersensitivity .
15905501	0	CD25	105,109	CD4	101,104	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficiency of the Src_homology_region_2_domain-containing_phosphatase_1 -LRB- SHP-1 -RRB- causes enrichment of CD4 + CD25 + regulatory T cells .
15905701	0	CD25	4,8	CD4	51,54	CD25	CD4	3559	920	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|regulate regulate|dobj|localization localization|nmod|reactive reactive|compound|END_ENTITY	CD4 + CD25 + T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen .
15922716	0	CD25	48,52	CD4	96,99	CD25	CD4	3559	920	Gene	Gene	induction|nmod|START_ENTITY Effects|dep|induction Effects|nmod|cells cells|compound|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
15935883	0	CD25	106,110	CD4	101,104	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
15944246	0	CD25	18,22	CD4	14,17	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : CD4 + CD25 + regulatory T cells impaired for intestinal homing can prevent colitis .
15946248	0	CD25	15,19	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY suppress|nsubj|cells +|ccomp|suppress +|nsubj|END_ENTITY	Activated CD4 + CD25 + T cells suppress antigen-specific CD4 + and CD8 + T cells but induce a suppressive phenotype only in CD4 + T cells .
15946248	0	CD25	15,19	CD4	55,58	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY suppress|nsubj|cells suppress|dobj|+ +|compound|END_ENTITY	Activated CD4 + CD25 + T cells suppress antigen-specific CD4 + and CD8 + T cells but induce a suppressive phenotype only in CD4 + T cells .
15958566	0	CD25	89,93	CD4	84,87	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	activities|compound|START_ENTITY activities|nummod|END_ENTITY	Tumor cyclooxygenase-2 / prostaglandin_E2-dependent promotion of FOXP3 expression and CD4 + CD25 + T regulatory cell activities in lung_cancer .
15962311	0	CD25	73,77	CD4	69,72	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine liver antigen presenting cells control suppressor activity of CD4 + CD25 + regulatory T cells .
15968737	0	CD25	13,17	CD4	18,21	CD25	CD4	16184(Tax:10090)	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD25 + CD4 + T cells -LRB- Tregs -RRB- enhances the HBV-specific CD8 + T cell response primed by DNA immunization .
15972628	0	CD25	37,41	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	In contrast to effector T cells , CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand - but not to TCR-mediated cell death .
15981474	0	CD25	49,53	CD4	55,58	CD25	CD4	3559	920	Gene	Gene	biology|compound|START_ENTITY biology|compound|END_ENTITY	The role of TCR specificity in naturally arising CD25 + CD4 + regulatory T cell biology .
15981476	0	CD25	31,35	CD4	26,29	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Selection and behavior of CD4 + CD25 + T cells in vivo : lessons from T cell receptor transgenic models .
15981486	0	CD25	56,60	CD4	52,55	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|dobj|+ +|nsubj|differences differences|nmod|END_ENTITY	Phenotypic and functional differences between human CD4 + CD25 + and type 1 regulatory T cells .
16002076	0	CD25	39,43	CD4	47,50	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Leukocyte CD40L_deficiency affects the CD25 -LRB- + -RRB- CD4 T cell population but does not affect atherosclerosis .
16009270	0	CD25	67,71	CD4	63,66	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|diversity diversity|nmod|END_ENTITY	TCRalphabeta repertoire diversity of human naturally occurring CD4 + CD25 + regulatory T cells .
16011520	0	CD25	5,9	CD4	0,3	CD25	CD4	3669	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	CD4 + CD25 + FOXP3 + regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses .
16014414	0	CD25	110,114	CD4	106,109	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4 + CD25 + regulatory cells .
16033398	0	CD25	58,62	CD4	54,57	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulation of nickel-induced T-cell responsiveness by CD4 + CD25 + cells in contact allergic patients and healthy individuals .
16036376	0	CD25	47,51	CD4	42,45	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neonatal_autoimmune_disease : influence of CD4 + CD25 + regulatory T cells .
16051465	0	CD25	28,32	CD4	33,36	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Effects of interleukin_4 on CD25 + CD4 + regulatory T cell function .
16091121	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + - regulatory T cells from mouse to man .
16106238	0	CD25	5,9	CD4	1,4	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- CD4 + CD25 + T regulatory cells in pathophysiology and therapy of immunologic_diseases -RSB- .
16108822	0	CD25	33,37	CD4	29,32	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory activity of human CD4 CD25 T cells depends on allergen concentration , type of allergen and atopy status of the donor .
16108825	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating and thymic CD4 CD25 T regulatory cells in myasthenia_gravis : effect of immunosuppressive treatment .
16116190	7	CD25	1006,1010	CD4	1002,1005	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Furthermore , passive transfer of CNS-derived CD4 + CD25 + cells in low numbers provides protection from EAE in recipient mice .
16121185	0	CD25	60,64	CD4	56,59	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Hassall 's corpuscles instruct dendritic cells to induce CD4 + CD25 + regulatory T cells in human thymus .
16122720	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the progression from periinsulitis to destructive_insulitis in murine autoimmune diabetes .
16127010	0	CD25	86,90	CD4	82,85	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Therapeutic T cell-based vaccination for neurodegenerative_disorders : the role of CD4 + CD25 + regulatory T cells .
16146782	0	CD25	27,31	CD4	23,26	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Signal transduction in CD4 + CD25 + regulatory T cells : CD25 and IL-2 .
16146782	0	CD25	53,57	CD4	23,26	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	transduction|dep|START_ENTITY transduction|nmod|cells cells|compound|END_ENTITY	Signal transduction in CD4 + CD25 + regulatory T cells : CD25 and IL-2 .
16150938	0	CD25	110,114	CD4	105,108	CD25	CD4	3559	920	Gene	Gene	mechanism|compound|START_ENTITY mechanism|compound|END_ENTITY	Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4 + CD25 + T-cell-dependent mechanism .
16177055	0	CD25	52,56	CD4	47,50	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : direct suppression of B cells by CD4 + CD25 + regulatory T cells .
16177056	0	CD25	128,132	CD4	123,126	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4 + CD25 + cells with characteristics of regulatory T cells .
16177065	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells inhibit the maturation but not the initiation of an autoantibody response .
16177068	0	CD25	64,68	CD4	59,62	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Protection against autoimmunity in nonlymphopenic hosts by CD4 + CD25 + regulatory T cells is antigen-specific and requires IL-10 and TGF-beta .
16177085	0	CD25	53,57	CD4	48,51	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IFN-gamma controls the generation/activation of CD4 + CD25 + regulatory T cells in antitumor immune response .
16178275	0	CD25	16,20	CD4	12,15	CD25	CD4	3669	920	Gene	Gene	regulatory|amod|START_ENTITY regulatory|compound|END_ENTITY	Circulating CD4 + CD25 + T regulatory and natural killer T cells in patients with myasthenia_gravis : a flow cytometry study .
16180248	0	CD25	29,33	CD4	24,27	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGF-beta1 production by CD4 + CD25 + regulatory T cells is not essential for suppression of intestinal_inflammation .
16193639	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Proportion of CD4 + CD25 + regulatory T cell is increased in the patients with ovarian_carcinoma .
16199095	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory/suppressor T cells prevent allogeneic fetus rejection in mice .
16199261	0	CD25	98,102	CD4	94,97	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Role of the T_cell_receptor_alpha_chain in the development and phenotype of naturally arising CD4 + CD25 + T cells .
16204628	0	CD25	44,48	CD4	40,43	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Vasoactive intestinal peptide generates CD4 + CD25 + regulatory T cells in vivo .
16210336	0	CD25	93,97	CD4	89,92	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , and not cyclosporin_A , preserves the highly suppressive CD27 + subset of human CD4 + CD25 + regulatory T cells .
16223778	0	CD25	89,93	CD4	84,87	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4 + CD25 + regulatory T cells .
16224273	0	CD25	73,77	CD4	69,72	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	LF 15-0195 generates synergistic tolerance by promoting formation of CD4 + CD25 + CTLA4 + T cells .
16227988	0	CD25	63,67	CD4	59,62	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lymphopenia and interleukin-2 therapy alter homeostasis of CD4 + CD25 + regulatory T cells .
16237044	0	CD25	18,22	CD4	14,17	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : CD4 + CD25 + regulatory T cells contribute to gender differences in susceptibility to experimental_autoimmune_encephalomyelitis .
16237107	0	CD25	99,103	CD4	104,107	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16257383	0	CD25	25,29	CD4	21,24	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vivo depletion of CD4 + CD25 + regulatory T cells enhances the antigen-specific primary and memory CTL response elicited by mature mRNA-electroporated dendritic cells .
16259008	0	CD25	45,49	CD4	41,44	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Genetic control of thymic development of CD4 + CD25 + FoxP3 + regulatory T lymphocytes .
16301616	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + CD25 + T cells prevent the development of organ-specific autoimmune_disease by inhibiting the differentiation of autoreactive effector T cells .
16301639	0	CD25	69,73	CD4	65,68	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Bone marrow-derived dendritic cells reverse the anergic state of CD4 + CD25 + T cells without reversing their suppressive function .
16301745	0	CD25	10,14	CD4	6,9	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Where CD4 + CD25 + T reg cells impinge on autoimmune diabetes .
16304057	0	CD25	35,39	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
16314435	0	CD25	84,88	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Resolution of airway_inflammation and hyperreactivity after in vivo transfer of CD4 + CD25 + regulatory T cells is interleukin_10 dependent .
16338210	0	CD25	80,84	CD4	76,79	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD28 superagonists put a break on autoimmunity by preferentially activating CD4 + CD25 + regulatory T cells .
16338494	0	CD25	58,62	CD4	54,57	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|dobj|cells	Increased induction of allogeneic-specific cord blood CD4 + CD25 + regulatory T -LRB- Treg -RRB- cells : a comparative study of na ve and antigenic-specific cord blood Treg cells .
16339524	0	CD25	61,65	CD4	57,60	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD18 is required for optimal development and function of CD4 + CD25 + T regulatory cells .
16339542	0	CD25	122,126	CD4	118,121	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16339542	0	CD25	122,126	CD4	6,9	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells express|ccomp|enhances express|nsubj|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16365425	0	CD25	19,23	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Specificity of CD4 + CD25 + regulatory T cell function in alloimmunity .
16380489	0	CD25	44,48	CD4	39,42	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Interleukin-7 is a survival factor for CD4 + CD25 + T-cells and is expressed by diabetes-suppressive_dendritic_cells .
16380492	0	CD25	57,61	CD4	53,56	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	The diabetes_type_1 locus Idd6 modulates activity of CD4 + CD25 + regulatory T-cells .
16393984	0	CD25	14,18	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Effect of CD4 + CD25 + and CD4 + CD25 - T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro .
16394018	0	CD25	21,25	CD4	17,20	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo-expanded CD4 + CD25 + immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells .
16403282	0	CD25	99,103	CD4	94,97	CD25	CD4	3559	920	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Role of LPS-stimulated human monocyte-derived dendritic cells in the modulation of autologous CD4 + CD25 + T Cell activation .
16403299	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Mechanism of CD4 + CD25 + and CD8 + regulatory T cells -- review -RSB- .
16415106	0	CD25	111,115	CD4	107,110	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4 + CD25 + cells in the recipient .
16424187	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells suppress NK cell-mediated immunotherapy of cancer .
16443370	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	The impact of CD4 + CD25 + Treg on tumor specific CD8 + T cell cytotoxicity and cancer .
16446379	0	CD25	41,45	CD4	37,40	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	B cell-deficient NOD.H-2h4 mice have CD4 + CD25 + T regulatory cells that inhibit the development of spontaneous_autoimmune_thyroiditis .
16455989	0	CD25	36,40	CD4	32,35	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Frequency of natural regulatory CD4 + CD25 + _ T lymphocytes determines the outcome of tolerance across fully mismatched MHC barrier through linked recognition of self and allogeneic stimuli .
16476010	0	CD25	20,24	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elimination of CD4 + CD25 + regulatory T cells breaks down reovirus_type_2-triggered and CpG ODN-induced prolonged mild autoimmune_insulitis in DBA/1 mice .
16479542	0	CD25	73,77	CD4	69,72	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Pertussis toxin as an adjuvant suppresses the number and function of CD4 + CD25 + T regulatory cells .
16505040	0	CD25	78,82	CD4	74,77	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of eye-derived tolerance does not depend on naturally occurring CD4 + CD25 + T regulatory cells .
16507266	0	CD25	73,77	CD4	68,71	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Isolation , identification and functional characterization of human CD4 + CD25 + Treg cells from human peripheral blood -RSB- .
16511897	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens .
16517695	0	CD25	116,120	CD4	112,115	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting Edge : Anti-CD25 monoclonal antibody injection results in the functional inactivation , not depletion , of CD4 + CD25 + T regulatory cells .
16517699	0	CD25	97,101	CD4	93,96	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
16525991	0	CD25	52,56	CD4	47,50	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Therapeutic potential of self-antigen-specific CD4 + CD25 + regulatory T cells selected in vitro from a polyclonal repertoire .
16547230	0	CD25	122,126	CD4	118,121	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	development|compound|START_ENTITY development|compound|END_ENTITY	Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5 ' - phosphatase are required for regulation of CD4 + CD25 + T cell development .
16555237	0	CD25	123,127	CD4	119,122	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY mitigated|dobj|cells mitigated|nmod|system system|nmod|depletion depletion|nmod|END_ENTITY	Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4 + CD25 + cells .
16585264	0	CD25	65,69	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Endogenous IRBP can be dispensable for generation of natural CD4 + CD25 + regulatory T cells that protect from IRBP-induced retinal autoimmunity .
16586370	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T cells in skin_lesions of patients with cutaneous_leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells .
16612280	0	CD25	33,37	CD4	29,32	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Thymocyte/splenocyte-derived CD4 + CD25 + Treg stimulated by anti-CD200R2 derived dendritic cells suppress mixed leukocyte cultures and skin graft rejection .
16621989	0	CD25	37,41	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CTLA-4 engagement and regulatory CD4 + CD25 + T cells independently control CD8 + - mediated responses under costimulation blockade .
16624084	0	CD25	6,10	CD4	40,43	CD25	CD4	3559	920	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|suppress suppress|dobj|responses responses|nummod|END_ENTITY	-LSB- CD4 + CD25 + regulatory T cells suppress CD4 + T cell responses in patients with persistent hepatitis_C_virus_infection -RSB- .
16630023	0	CD25	61,65	CD4	57,60	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation .
16632602	0	CD25	63,67	CD4	58,61	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Toll-like_receptor_2 signaling modulates the functions of CD4 + CD25 + regulatory T cells .
16645171	0	CD25	45,49	CD4	41,44	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16670295	0	CD25	0,4	CD4	42,45	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|facilitate facilitate|xcomp|induction induction|nsubj|clonal clonal|compound|END_ENTITY	CD25 + Foxp3 + regulatory T cells facilitate CD4 + T cell clonal anergy induction during the recovery from lymphopenia .
16670346	0	CD25	17,21	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	Influence|nmod|START_ENTITY +|nsubj|Influence +|nmod|cells cells|compound|END_ENTITY	Influence of CD4 + CD25 + regulatory T cells on low/high-avidity CD4 + T cells following peptide vaccination .
16677453	0	CD25	31,35	CD4	26,29	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects and mechanism of CD4 + CD25 + T cells on the airway inflammation of asthmatic mice -RSB- .
16680369	0	CD25	16,20	CD4	12,15	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dynamics of CD4 + CD25 + T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma_japonicum .
16696899	0	CD25	102,106	CD4	98,101	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The ex vivo microenviroments in MLTC of poorly immunogenic tumor cells facilitate polarization of CD4 + CD25 + regulatory T cells .
16698419	0	CD25	22,26	CD4	17,20	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Foxp3 expressing CD4 + CD25 + and CD8 + CD28 - T regulatory cells in the peripheral blood of patients with lung_cancer and pleural_mesothelioma .
16709816	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T cells and CD4 + CD25-Foxp3 + T cells in aged mice .
16714584	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells modulate the T-cell and antibody responses in helicobacter-infected BALB/c mice .
16723631	0	CD25	19,23	CD4	15,18	CD25	CD4	3669	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	An increase in CD4 + CD25 + FOXP3 + regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme .
16734136	0	CD25	15,19	CD4	11,14	CD25	CD4	3559	920	Gene	Gene	T-lymphocytes|compound|START_ENTITY +|dobj|T-lymphocytes +|nsubj|END_ENTITY	Diminished CD4 + CD25 + T-lymphocytes in peripheral blood of patients with systemic_lupus_erythematosus .
16735139	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Tregs and NKT cells : regulators regulating regulators .
16735466	0	CD25	118,122	CD4	114,117	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4 + CD25 + cells and TGF-beta .
16741512	0	CD25	24,28	CD4	20,23	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Lack of suppressive CD4 + CD25 + FOXP3 + T cells in advanced stages of primary cutaneous_T-cell_lymphoma .
16741709	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells induced by LPS-activated bone marrow dendritic cells suppress experimental autoimmune uveoretinitis in vivo .
16751356	0	CD25	29,33	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : allogeneic CD4 + CD25 + Foxp3 + T regulatory cells suppress autoimmunity while establishing transplantation tolerance .
16751371	4	CD25	775,779	CD4	769,772	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|amod|END_ENTITY	IL-1beta drives proliferation and cytokine production by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- - -RRB- effector/memory T cells , attenuates CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cell function , and allows escape of CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- autoreactive effectors from suppression .
16758122	0	CD25	37,41	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Levels of circulating regulatory CD4 + CD25 + T cells are decreased in breast_cancer patients after vaccination with a HER2/neu peptide -LRB- E75 -RRB- and GM-CSF vaccine .
16766044	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells and CD1-restricted NKT cells do not mediate facial motoneuron survival after axotomy .
16767222	0	CD25	36,40	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Heat_shock protein 60 enhances CD4 + CD25 + regulatory T cell function via innate TLR2 signaling .
16771859	0	CD25	113,117	CD4	108,111	CD25	CD4	3559	920	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Cytotoxic_T_lymphocyte_antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4 + CD25 + regulatory T-cell-mediated suppression .
16775487	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + cell depletion from the normal CD4 + T cell pool prevents tolerance toward the intestinal flora and leads to chronic_colitis in immunodeficient mice .
16775487	0	CD25	4,8	CD4	41,44	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|nmod|pool pool|compound|END_ENTITY	CD4 + CD25 + cell depletion from the normal CD4 + T cell pool prevents tolerance toward the intestinal flora and leads to chronic_colitis in immunodeficient mice .
16785514	0	CD25	77,81	CD4	73,76	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Indexation as a novel mechanism of lymphocyte homeostasis : the number of CD4 + CD25 + regulatory T cells is indexed to the number of IL-2-producing cells .
16785520	0	CD25	10,14	CD4	6,9	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	FOXP3 + CD4 + CD25 + adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin_E2-dependent mechanism .
16804081	0	CD25	89,93	CD4	85,88	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4 + CD25 + T-cell-mediated regulation and type 1 diabetes development in NOD mice .
16861937	0	CD25	56,60	CD4	52,55	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppressor function of umbilical cord blood-derived CD4 + CD25 + T-regulatory cells exposed to graft-versus-host_disease drugs .
16873284	0	CD25	11,15	CD4	6,9	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY suppress|nsubj|cells +|ccomp|suppress +|nsubj|END_ENTITY	Human CD4 + CD25 high cells suppress proliferative memory lymphocyte responses to herpes_simplex_virus_type_2 .
16887978	0	CD25	110,114	CD4	106,109	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4 + CD25 + regulatory T cells .
16888164	0	CD25	44,48	CD4	40,43	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Vasoactive intestinal peptide generates CD4 + CD25 + regulatory T cells in vivo : therapeutic applications in autoimmunity and transplantation .
16893499	0	CD25	70,74	CD4	66,69	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|characterization characterization|nmod|END_ENTITY	The phenotypic characterization of naturally occurring regulatory CD4 + CD25 + T cells .
16902287	0	CD25	32,36	CD4	27,30	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Identification of lesional CD4 + CD25 + Foxp3 + regulatory T cells in Psoriasis .
16903906	0	CD25	42,46	CD4	37,40	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The lifestyle of naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells .
16906223	0	CD25	63,67	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|cells cells|nmod|Tregs Tregs|compound|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16914538	0	CD25	74,78	CD4	70,73	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel mechanism of action for anti-thymocyte globulin : induction of CD4 + CD25 + Foxp3 + regulatory T cells .
16917540	0	CD25	55,59	CD4	50,53	CD25	CD4	3559	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	PTEN inhibits IL-2 receptor-mediated expansion of CD4 + CD25 + Tregs .
16926292	0	CD25	44,48	CD4	39,42	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY express|nsubj|cells +|ccomp|express +|nsubj|END_ENTITY	Most human thymic and peripheral-blood CD4 + CD25 + regulatory T cells express 2 T-cell receptors .
16926600	0	CD25	69,73	CD4	65,68	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Calcineurin inhibitors , but not rapamycin , reduce percentages of CD4 + CD25 + FOXP3 + regulatory T cells in renal transplant recipients .
16943228	0	CD25	23,27	CD4	19,22	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Supplementation of CD4 + CD25 + regulatory T cells suppresses experimental autoimmune uveoretinitis .
16943258	0	CD25	60,64	CD4	56,59	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	An MHC-linked locus modulates thymic differentiation of CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
16951329	0	CD25	85,89	CD4	81,84	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Protection from type_1_diabetes by invariant NK T cells requires the activity of CD4 + CD25 + regulatory T cells .
16952047	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells promotes a tumor-specific immune response in pancreas_cancer-bearing mice .
16960692	0	CD25	61,65	CD4	57,60	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Metronomic_cyclophosphamide regimen selectively depletes CD4 + CD25 + regulatory T cells and restores T and NK effector functions in end stage cancer patients .
16982872	0	CD25	26,30	CD4	22,25	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Blockade of CTLA-4 on CD4 + CD25 + regulatory T cells abrogates their function in vivo .
16982893	0	CD25	0,4	CD4	5,8	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD25 + CD4 + regulatory T cells and memory T cells prevent lymphopenia-induced proliferation of naive T cells in transient states of lymphopenia .
16987936	0	CD25	94,98	CD4	90,93	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Competition controls the rate of transition between the peripheral pools of CD4 + CD25 - and CD4 + CD25 + T cells .
16998360	0	CD25	15,19	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Increased CD4 + CD25 + T regulatory cell activity in trauma patients depresses protective Th1 immunity .
17003369	0	CD25	49,53	CD4	45,48	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-expanded donor alloantigen-specific CD4 + CD25 + regulatory T cells promote experimental transplantation tolerance .
17011048	0	CD25	4,8	CD4	0,3	CD25	CD4	3669	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + FoxP3 + T lymphocytes fail to suppress myelin_basic_protein-induced proliferation in patients with multiple_sclerosis .
17015695	0	CD25	88,92	CD4	84,87	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17024440	0	CD25	13,17	CD4	9,12	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Roles of CD4 + CD25 + T cells in the development of experimental murine allergic_conjunctivitis .
17031470	0	CD25	61,65	CD4	57,60	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction and maintenance of self tolerance : the role of CD4 + CD25 + regulatory T cells .
17038912	0	CD25	108,112	CD4	76,79	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|nmod|START_ENTITY Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD25	80,84	CD4	104,107	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nmod|CD25 CD25|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD25	80,84	CD4	76,79	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17042799	0	CD25	49,53	CD4	45,48	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Schistosoma japonicum egg antigens stimulate CD4 CD25 T cells and modulate airway_inflammation in a murine model of asthma .
17053815	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-cell-inactivation|compound|START_ENTITY T-cell-inactivation|compound|END_ENTITY	CD4 + CD25 + regulatory T-cell-inactivation in combination with adenovirus vaccines enhances T-cell responses and protects mice from tumor challenge .
17056509	0	CD25	30,34	CD4	26,29	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of Foxp3 + CD4 + CD25 + and IL-10-secreting CD4 + CD25 + T cells during cure of colitis .
17068147	0	CD25	64,68	CD4	60,63	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Early CD30 signaling is critical for adoptively transferred CD4 + CD25 + regulatory T cells in prevention of acute_graft-versus-host_disease .
17082571	0	CD25	91,95	CD4	87,90	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Cutting edge : the phosphoinositide_3-kinase_p110_delta is critical for the function of CD4 + CD25 + Foxp3 + regulatory T cells .
17082572	0	CD25	96,100	CD4	92,95	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cyclophosphamide-induced type-1_diabetes in the NOD mouse is associated with a reduction of CD4 + CD25 + Foxp3 + regulatory T cells .
17082610	0	CD25	65,69	CD4	38,41	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY imposed|nmod|cells imposed|nmod|targets targets|compound|END_ENTITY	Distinct molecular program imposed on CD4 + T cell targets by CD4 + CD25 + regulatory T cells .
17082610	0	CD25	65,69	CD4	61,64	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct molecular program imposed on CD4 + T cell targets by CD4 + CD25 + regulatory T cells .
17082633	0	CD25	33,37	CD4	29,32	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Lipopolysaccharide-activated CD4 + CD25 + T regulatory cells inhibit neutrophil function and promote their apoptosis and death .
17100770	0	CD25	67,71	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Evidence for immunological priming and increased frequency of CD4 + CD25 + cord blood T cells in children born to mothers with type_1_diabetes .
17105491	0	CD25	84,88	CD4	80,83	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The initial phase of graft-versus-host_disease is associated with a decrease of CD4 + CD25 + regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation .
17109733	0	CD25	48,52	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	pool|compound|START_ENTITY pool|compound|END_ENTITY	Following anti-CD25 treatment , a functional CD4 + CD25 + regulatory T-cell pool is present in renal transplant recipients .
17110462	0	CD25	57,61	CD4	53,56	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Galectin-1 : a key effector of regulation mediated by CD4 + CD25 + T cells .
17111920	0	CD25	34,38	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The role of regulatory cells CD4 + CD25 + in the development of chronic infective diseases -RSB- .
17114433	0	CD25	97,101	CD4	119,122	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Oral tolerance induction with antigen conjugated to cholera_toxin_B_subunit generates both Foxp3 + CD25 + and Foxp3-CD25 - CD4 + regulatory T cells .
17114466	0	CD25	22,26	CD4	18,21	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased natural CD4 + CD25 + regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis .
17130526	0	CD25	39,43	CD4	35,38	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A mini meta-analysis of studies on CD4 + CD25 + T cells in human type 1 diabetes : report of the Immunology of Diabetes_Society_T Cell Workshop .
17142730	0	CD25	47,51	CD4	43,46	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients .
17154263	0	CD25	19,23	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Activation of CD4 + CD25 + regulatory T cell suppressor function by analogs of the selecting peptide .
17161354	0	CD25	16,20	CD4	11,14	CD25	CD4	3559	920	Gene	Gene	expansion|compound|START_ENTITY expansion|compound|END_ENTITY	Peripheral CD4 + CD25 + Treg cell expansion in lung transplant recipients is not affected by calcineurin_inhibitors .
17175221	0	CD25	58,62	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Adoptive cell therapy using in vitro generated human CD4 + CD25 + regulatory t cells with indirect allospecificity to promote donor-specific transplantation tolerance .
17181632	0	CD25	46,50	CD4	42,45	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Frequency , function and CLA expression of CD4 + CD25 + FOXP3 + regulatory T cells in bullous pemphigoid .
17182564	0	CD25	68,72	CD4	64,67	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4 + CD25 + T cell regulatory functions .
17182566	0	CD25	0,4	CD4	5,8	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	migration|compound|START_ENTITY migration|compound|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
17182569	0	CD25	52,56	CD4	48,51	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Selective survival of naturally occurring human CD4 + CD25 + Foxp3 + regulatory T cells cultured with rapamycin .
17182968	0	CD25	19,23	CD4	15,18	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Association of CD4 + CD25 + Foxp3 + regulatory T cells with chronic activity and viral clearance in patients with hepatitis_B .
17198271	0	CD25	88,92	CD4	83,86	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Targeting acute allograft rejection by immunotherapy with ex vivo-expanded natural CD4 + CD25 + regulatory T cells .
17205133	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	CD4 + CD25 + FOXP3 + regulatory T cells suppress anti-tumor immune responses in patients with colorectal_cancer .
17210729	0	CD25	45,49	CD4	40,43	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD62L|compound|START_ENTITY CD62L|compound|END_ENTITY	Dendritic cell-expanded , islet-specific CD4 + CD25 + CD62L + regulatory T cells restore normoglycemia in diabetic_NOD mice .
17216339	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + T-cell infiltration and heme_oxygenase-1 expression correlate with tumor grade in human gliomas .
17217750	0	CD25	18,22	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- The role of CD4 + CD25 + T cell and FOXP3 in hsot acute graft rejection -RSB- .
17244157	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY -LSB-|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17244157	0	CD25	5,9	CD4	55,58	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY corrected|nsubj|-LSB- corrected|ccomp|render render|dobj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17244157	0	CD25	60,64	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	render|dobj|START_ENTITY corrected|ccomp|render corrected|nsubj|-LSB- -LSB-|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17258077	0	CD25	51,55	CD4	39,42	CD25	CD4	3559	920	Gene	Gene	IL-2-independent|dep|START_ENTITY IL-2-independent|dobj|generation generation|nmod|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17259178	0	CD25	30,34	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	GRAIL is up-regulated in CD4 + CD25 + T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype .
17270031	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells enhances interleukin-2-induced antitumor immunity in a mouse model of colon_adenocarcinoma .
17270282	0	CD25	21,25	CD4	101,104	CD25	CD4	3559	920	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|costimulation costimulation|nmod|cells cells|compound|END_ENTITY	CpG DNA inhibits CD4 + CD25 + Treg suppression through direct MyD88-dependent costimulation of effector CD4 + T cells .
17270282	0	CD25	21,25	CD4	17,20	CD25	CD4	3559	920	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	CpG DNA inhibits CD4 + CD25 + Treg suppression through direct MyD88-dependent costimulation of effector CD4 + T cells .
17277105	0	CD25	67,71	CD4	48,51	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells CD25|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17277153	0	CD25	101,105	CD4	97,100	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4 + CD25 + regulatory T cells .
17277167	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of CD4 + CD25 + and FOXP3 + regulatory T cells during the follicular phase of the menstrual cycle : implications for human reproduction .
17289657	0	CD25	66,70	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	present|compound|START_ENTITY present|compound|END_ENTITY	Dendritic_cells partially abrogate the regulatory activity of CD4 + CD25 + T cells present in the human peripheral blood .
17304105	0	CD25	25,29	CD4	20,23	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-regulatory-cells|compound|START_ENTITY T-regulatory-cells|compound|END_ENTITY	The contribution of CD4 + CD25 + T-regulatory-cells to immune suppression in sepsis .
17312121	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T cell-dependent inhibition of autoimmunity in transgenic_mice overexpressing human Bcl-2 in T lymphocytes .
17316678	0	CD25	36,40	CD4	32,35	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The clonal composition of human CD4 + CD25 + Foxp3 + cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements .
17325053	0	CD25	5,9	CD4	39,42	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|suppress suppress|ccomp|function function|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress CD4 + T-cell function and inhibit the development of Plasmodium_berghei-specific TH1 responses involved in cerebral_malaria pathogenesis .
17331841	0	CD25	65,69	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The effect of immunosuppressive drug rapamycin on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
17350019	0	CD25	16,20	CD4	11,14	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells expand during experimental Plasmodium infection but do not prevent cerebral_malaria .
17351648	0	CD25	91,95	CD4	86,89	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , not cyclosporine , permits thymic generation and peripheral preservation of CD4 + CD25 + FoxP3 + T cells .
17353088	0	CD25	45,49	CD4	88,91	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|acl:relcl|T T|nsubj|cells cells|nmod|CD25 CD25|compound|END_ENTITY	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17353088	0	CD25	94,98	CD4	39,42	CD25	CD4	3559	920	Gene	Gene	cells|nmod|START_ENTITY T|nsubj|cells CD25|acl:relcl|T CD25|compound|END_ENTITY	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17356295	0	CD25	20,24	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Thymus-derived CD4 + CD25 + T cells suppress the development of murine allergic_conjunctivitis .
17362490	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + transforming growth factor-beta-producing T cells are present in the lung in murine tuberculosis and may regulate the host inflammatory response .
17368474	0	CD25	37,41	CD4	33,36	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A CFSE based assay for measuring CD4 + CD25 + regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses .
17369190	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells are activated in vivo by recognition of self .
17369496	0	CD25	15,19	CD4	11,14	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Changes of CD4 + CD25 + Foxp3 + regulatory T cells in aged Balb/c mice .
17371928	0	CD25	50,54	CD4	45,48	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCR7 is required for the in vivo function of CD4 + CD25 + regulatory T cells .
17371959	0	CD25	37,41	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	GITR|compound|START_ENTITY GITR|compound|END_ENTITY	Follicular_lymphoma intratumoral CD4 + CD25 + GITR + regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8 + CD25 - and CD4 + CD25 - T cells .
17371960	0	CD25	52,56	CD4	48,51	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Function of the IL-2R for thymic and peripheral CD4 + CD25 + Foxp3 + T regulatory cells .
17371975	0	CD25	114,118	CD4	110,113	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4 + CD25 + regulatory T cells .
17389235	0	CD25	64,68	CD4	60,63	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17391121	0	CD25	53,57	CD4	58,61	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR ligation blocks allograft protection by induced CD25 + CD4 + regulatory T cells without enhancing effector T-cell function .
17393103	0	CD25	17,21	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Analysis of CD4 + CD25 + regulatory T cells and Foxp3 mRNA in the peripheral blood of patients with asthma .
17404275	0	CD25	40,44	CD4	36,39	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Intestinal lamina propria retaining CD4 + CD25 + regulatory T cells is a suppressive site of intestinal inflammation .
17414712	0	CD25	79,83	CD4	75,78	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Involvement of the programmed death-1 / programmed death-1 ligand pathway in CD4 + CD25 + regulatory T-cell activity to suppress alloimmune responses .
17425604	0	CD25	121,125	CD4	116,119	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4 + CD25 + cells .
17428252	0	CD25	88,92	CD4	83,86	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Diabetes_in_non-obese diabetic mice is not associated with quantitative changes in CD4 + CD25 + Foxp3 + regulatory T cells .
17433300	0	CD25	57,61	CD4	52,55	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Schistosoma_japonicum eggs modulate the activity of CD4 + CD25 + Tregs and prevent development of colitis in mice .
17449724	0	CD25	147,151	CD4	143,146	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4 + CD25 + regulatory T cells .
17463169	0	CD25	15,19	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic_anemia .
17468835	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells decreased the antitumor activity of cytokine-induced killer -LRB- CIK -RRB- cells of lung_cancer patients .
17478450	0	CD25	80,84	CD4	76,79	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses .
17490400	0	CD25	53,57	CD4	48,51	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Daily subcutaneous injections of peptide induce CD4 + CD25 + T regulatory cells .
17495135	0	CD25	139,143	CD4	135,138	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting_cells but not by CD4 + CD25 + regulatory T cells .
17512253	0	CD25	41,45	CD4	37,40	CD25	CD4	3559	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	The opposite-direction modulation of CD4 + CD25 + Tregs and T helper 1 cells in acute_coronary_syndromes .
17513712	0	CD25	96,100	CD4	101,104	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CNS CD11c + cells from mice with encephalomyelitis polarize Th17 cells and support CD25 + CD4 + T cell-mediated immunosuppression , suggesting dual roles in the disease process .
17513732	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B_cell_lymphoma model .
17523950	0	CD25	161,165	CD4	157,160	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	A dual altered peptide ligand inhibits myasthenia_gravis associated responses by inducing phosphorylated extracellular-regulated kinase 1,2 that upregulates CD4 + CD25 + Foxp3 + cells .
17524860	0	CD25	63,67	CD4	59,62	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Calcitriol started in the donor , expands the population of CD4 + CD25 + T cells in renal transplant recipients .
17541623	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation .
17545218	0	CD25	91,95	CD4	149,152	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells promotes|dobj|differentiation promotes|nmod|cells cells|nummod|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17545218	0	CD25	91,95	CD4	87,90	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17545278	0	CD25	30,34	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	The maintenance of human CD4 + CD25 + regulatory T cell function : IL-2 , IL-4 , IL-7 and IL-15 preserve optimal suppressive potency in vitro .
17548589	0	CD25	34,38	CD4	30,33	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Agonist-driven development of CD4 + CD25 + Foxp3 + regulatory T cells requires a second signal mediated by Stat6 .
17563757	0	CD25	22,26	CD4	18,21	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Downregulation of CD4 + CD25 + regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells .
17565319	0	CD25	45,49	CD4	50,53	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Regulation of transplant_arteriosclerosis by CD25 + CD4 + T cells generated to alloantigen in vivo .
17579033	0	CD25	89,93	CD4	85,88	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4 + CD25 + T regulatory cells .
17582431	0	CD25	65,69	CD4	61,64	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flow cytometry-based methods for studying signaling in human CD4 + CD25 + FOXP3 + T regulatory cells .
17591854	0	CD25	57,61	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Expansion and tissue infiltration of an allospecific CD4 + CD25 + CD45RO + IL-7Ralphahigh cell population in solid organ transplant recipients .
17596146	0	CD25	38,42	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Evaluation of tumour-infiltrating CD4 + CD25 + FOXP3 + regulatory T cells in human cutaneous benign and atypical naevi , melanomas and melanoma metastases .
17601373	0	CD25	38,42	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY occurring|nsubj|cells occurring|dobj|END_ENTITY	Naturally occurring self-reactive CD4 + CD25 + regulatory T cells : universal immune code .
17615291	0	CD25	103,107	CD4	99,102	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
17617562	0	CD25	87,91	CD4	83,86	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : high molecular weight hyaluronan promotes the suppressive effects of CD4 + CD25 + regulatory T cells .
17618567	0	CD25	26,30	CD4	21,24	CD25	CD4	3559	713807(Tax:9544)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- Characterization of CD4 + CD25 + T lymphocytes in the peripheral blood of Chinese rhesus_macaques -LRB- Macaca_mulatta -RRB- -RSB- .
17621372	0	CD25	34,38	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17627234	0	CD25	88,92	CD4	84,87	CD25	CD4	3559	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4 + CD25 + GITR+F oxp3 + CD62L + functional regulatory T-cells in patients with graft-versus-host_disease .
17635813	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + indirect alloreactive T cells from renal transplant patients suppress both the direct and indirect pathways of allorecognition .
17641007	0	CD25	94,98	CD4	77,80	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|conversion conversion|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17641646	0	CD25	28,32	CD4	23,26	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|generation generation|nmod|END_ENTITY	In vitro generation of CD4 + CD25 + regulatory cells from murine naive T cells .
17645467	0	CD25	26,30	CD4	21,24	CD25	CD4	3559	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Impaired function of CD4 + / CD25 + T regulatory lymphocytes characterizes the self-limited hepatitis_A_virus_infection .
17651141	0	CD25	25,29	CD4	21,24	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immune regulation by CD4 + CD25 + T cells and interleukin-10 in birch pollen-allergic patients and non-allergic controls .
17684039	0	CD25	73,77	CD4	69,72	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Blockade of chronic graft-versus-host_disease by alloantigen-induced CD4 + CD25 + Foxp3 + regulatory T cells in nonlymphopenic hosts .
17687106	0	CD25	108,112	CD4	104,107	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4 + CD25 + Foxp3 + regulatory T cells .
17711492	0	CD25	24,28	CD4	19,22	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dynamic changes in CD4 + CD25 + -LRB- high -RRB- T cell apoptosis after the diagnosis of type_1_diabetes .
17764450	0	CD25	17,21	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD25 + regulatory T cells correlate with chronic hepatitis_B_infection .
17785792	0	CD25	57,61	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17785792	0	CD25	57,61	CD4	73,76	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY transcription|nmod|cells suppression|nmod|transcription suppression|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17785799	0	CD25	176,180	CD4	172,175	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4 + CD25 + regulatory T cells .
17826032	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune_thyroiditis in NOD-H2h4 mice .
17851131	0	CD25	29,33	CD4	98,101	CD25	CD4	3669	920	Gene	Gene	frequency|nmod|START_ENTITY inhibit|nsubj|frequency inhibit|dobj|induction induction|nmod|cells cells|amod|IFN-gamma IFN-gamma|nmod|T T|compound|END_ENTITY	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
17868677	0	CD25	24,28	CD4	20,23	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural regulatory -LRB- CD4 + CD25 + FOXP + -RRB- T cells control the production of pro-inflammatory cytokines during Plasmodium_chabaudi adami infection and do not contribute to immune evasion .
17868905	0	CD25	60,64	CD4	54,57	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|nsubj|characterisation characterisation|nmod|END_ENTITY	Phenotypic and functional characterisation of porcine CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- regulatory T cells .
17875988	0	CD25	25,29	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|+ +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD25	65,69	CD4	21,24	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells CD25|acl|+ CD25|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD25	65,69	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17896973	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells and TGF-beta in mucosal immune system : the good and the bad .
17898053	0	CD25	7,11	CD4	133,136	CD25	CD4	3559	920	Gene	Gene	T-cell|compound|START_ENTITY macaques|nsubj|T-cell macaques|nmod|activation activation|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
17911604	0	CD25	59,63	CD4	55,58	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
17912440	0	CD25	55,59	CD4	51,54	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Imatinib impairs the proliferation and function of CD4 + CD25 + regulatory T cells in a dose-dependent manner .
17917056	0	CD25	19,23	CD4	15,18	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Natural Tregs , CD4 + CD25 + inhibitory hybridomas , and their cell contact dependent suppression .
17920698	0	CD25	117,121	CD4	32,35	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	effector|nmod|START_ENTITY effector|dep|allows allows|nsubj|expression expression|nmod|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17920698	0	CD25	117,121	CD4	58,61	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	effector|nmod|START_ENTITY effector|dep|allows allows|xcomp|antigen-specific antigen-specific|nsubj|distinction distinction|nmod|CD25 CD25|compound|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17920698	0	CD25	64,68	CD4	111,114	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	distinction|nmod|START_ENTITY antigen-specific|nsubj|distinction allows|xcomp|antigen-specific effector|dep|allows effector|nmod|CD25 CD25|compound|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17920698	0	CD25	64,68	CD4	32,35	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	distinction|nmod|START_ENTITY antigen-specific|nsubj|distinction allows|xcomp|antigen-specific allows|nsubj|expression expression|nmod|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17944116	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CD4 + CD25 + T cells in rheumatic_mitral_stenosis .
17956583	0	CD25	17,21	CD4	184,187	CD25	CD4	3559	920	Gene	Gene	Increase|nmod|START_ENTITY +|nsubj|Increase +|parataxis|using using|xcomp|cyclophosphamide cyclophosphamide|xcomp|eliminate eliminate|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	Increase of CD4 + CD25 + regulatory T cells in the peripheral blood of patients with metastatic_carcinoma : a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4 + CD25 + T lymphocytes .
17956583	0	CD25	189,193	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	lymphocytes|compound|START_ENTITY eliminate|dobj|lymphocytes cyclophosphamide|xcomp|eliminate using|xcomp|cyclophosphamide +|parataxis|using +|nsubj|Increase Increase|nmod|CD25 CD25|compound|END_ENTITY	Increase of CD4 + CD25 + regulatory T cells in the peripheral blood of patients with metastatic_carcinoma : a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4 + CD25 + T lymphocytes .
17956583	0	CD25	189,193	CD4	184,187	CD25	CD4	3559	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|nummod|END_ENTITY	Increase of CD4 + CD25 + regulatory T cells in the peripheral blood of patients with metastatic_carcinoma : a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4 + CD25 + T lymphocytes .
17966042	0	CD25	101,105	CD4	97,100	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	The severity of systemic_lupus_erythematosus_negatively_correlates with the increasing number of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells during repeated plasmapheresis treatments of patients .
17967941	0	CD25	71,75	CD4	129,132	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY inhibition|nmod|Foxp3 impact|nmod|inhibition +|nsubj|impact +|advcl|cells cells|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17967941	0	CD25	71,75	CD4	67,70	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17968332	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells in autoimmune_diseases .
17980384	0	CD25	25,29	CD4	21,24	CD25	CD4	493953(Tax:9685)	493775(Tax:9685)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|depletion depletion|nmod|END_ENTITY	In vivo depletion of CD4 + CD25 + regulatory T cells in cats .
17981641	0	CD25	24,28	CD4	19,22	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IL-2 signaling and CD4 + CD25 + Foxp3 + regulatory T cells .
17981643	0	CD25	53,57	CD4	48,51	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Factors regulating apoptosis and homeostasis of CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells are new therapeutic targets .
17982096	0	CD25	78,82	CD4	74,77	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Resolution of Der p1-induced allergic airway inflammation is dependent on CD4 + CD25 + Foxp3 + regulatory cells .
17982458	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
17982458	0	CD25	4,8	CD4	94,97	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|induce induce|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
17990114	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells have divergent effects on intestinal_inflammation in IL-10 gene-deficient mice .
18021363	0	CD25	16,20	CD4	11,14	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + T cells prevent thymic dysfunction in experimental chronic colitis .
18025172	0	CD25	25,29	CD4	21,24	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2_and_4-1BB signaling .
18025205	0	CD25	21,25	CD4	17,20	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18027108	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells : from basic research to potential therapeutic use .
18032693	0	CD25	49,53	CD4	45,48	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Regulation of the NFAT pathway discriminates CD4 + CD25 + regulatory T cells from CD4 + CD25 - helper T cells .
18032693	0	CD25	49,53	CD4	79,82	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY discriminates|dobj|cells discriminates|nmod|CD25 CD25|compound|END_ENTITY	Regulation of the NFAT pathway discriminates CD4 + CD25 + regulatory T cells from CD4 + CD25 - helper T cells .
18032693	0	CD25	83,87	CD4	45,48	CD25	CD4	3559	920	Gene	Gene	discriminates|nmod|START_ENTITY discriminates|dobj|cells cells|nummod|END_ENTITY	Regulation of the NFAT pathway discriminates CD4 + CD25 + regulatory T cells from CD4 + CD25 - helper T cells .
18036640	0	CD25	49,53	CD4	45,48	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation of NK_T-like_CD3 + CD56 + cells and CD4 + CD25 + -LRB- hi -RRB- regulatory T cells with VEGF and TNFalpha in ascites from advanced ovarian_cancer : Association with platinum resistance and prognosis in patients receiving first-line , platinum-based chemotherapy .
18038774	0	CD25	16,20	CD4	12,15	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Changes of CD4 + CD25 + T cells in the spleen of mice infected with Toxoplasma_gondii -RSB- .
18042719	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce alternative activation of human monocytes/macrophages .
18053016	0	CD25	42,46	CD4	38,41	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The functional insufficiency of human CD4 + CD25 high T-regulatory cells in allergic_asthma is subjected to TNF-alpha modulation .
18058571	0	CD25	14,18	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Targeting CD4 + CD25 + FoxP3 + regulatory T-cells for the augmentation of cancer immunotherapy .
18066074	0	CD25	61,65	CD4	57,60	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Prevention of acute and chronic allograft rejection with CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
18070209	0	CD25	35,39	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional characterization of CD4 + CD25 + regulatory T cells differentiated in vitro from bone marrow-derived haematopoietic cells of psoriasis patients with a family history of the disorder .
18091047	0	CD25	94,98	CD4	90,93	CD25	CD4	3559	920	Gene	Gene	homeostasis|compound|START_ENTITY homeostasis|compound|END_ENTITY	Transforming_growth_factor-beta / transforming_growth_factor-betaRII signaling may regulate CD4 + CD25 + T-regulatory cell homeostasis and suppressor function in feline AIDS_lentivirus_infection .
18092144	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The role of CD4 + CD25 + T regulatory cells in autoimmune_diseases .
18159952	0	CD25	173,177	CD4	169,172	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Repeated 0.5-Gy gamma irradiation attenuates autoimmune_disease in MRL-lpr/lpr mice with suppression of CD3 + CD4-CD8-B220 + T-cell proliferation and with up-regulation of CD4 + CD25 + Foxp3 + regulatory T cells .
18171291	0	CD25	16,20	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	CD4 -LRB- + -RRB- -LRB- and not CD25 + -RRB- T cells are the predominant interleukin-10-producing cells in the circulation of filaria-infected patients .
18178825	0	CD25	54,58	CD4	50,53	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expansion improves in vivo regulation by CD4 + CD25 + regulatory T cells .
18178849	0	CD25	68,72	CD4	64,67	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha antagonism generates a population of antigen-specific CD4 + CD25 + T cells that inhibit protective immunity in murine histoplasmosis .
18190656	0	CD25	29,33	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Ex vivo-expanded natural CD4 + CD25 + regulatory T cells synergize with host T-cell depletion to promote long-term survival of allografts .
18204854	0	CD25	60,64	CD4	56,59	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Aerobic training increases the stimulated percentage of CD4 + CD25 + in older men but not older women .
18221522	0	CD25	93,97	CD4	89,92	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4 + CD25 + regulatory T cells in Peyer 's patches in an orally tolerized , collagen-induced_arthritis mouse model .
18231887	0	CD25	29,33	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Alteration of peripheral CD4 + CD25 + regulatory T lymphocytes in pregnancy and pre-eclampsia .
18248531	0	CD25	33,37	CD4	38,41	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD_127 - and FoxP3 + expression on CD25 + CD4 + T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type_1_diabetes_mellitus patients .
18256318	0	CD25	103,107	CD4	99,102	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Autologous bone marrow transplantation in autoimmune_arthritis restores immune homeostasis through CD4 + CD25 + Foxp3 + regulatory T cells .
18261176	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	CD4 + CD25 + FOXP3 + regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H .
18269341	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory T cells : a therapeutic target for liver_diseases .
18270248	0	CD25	42,46	CD4	38,41	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR .
18270250	0	CD25	47,51	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY cells|nmod|FOXP3 cells|compound|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18270250	0	CD25	47,51	CD4	43,46	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18272926	0	CD25	31,35	CD4	50,53	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|nmod|cells cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD25	54,58	CD4	27,30	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells CD25|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD25	54,58	CD4	50,53	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18281535	0	CD25	30,34	CD4	26,29	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Enhanced functionality of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells in the peripheral blood of patients with prostate_cancer .
18287134	0	CD25	4,8	CD4	0,3	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + FOXP3 + T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple_myeloma following allogeneic stem cell transplantation .
18295349	0	CD25	79,83	CD4	75,78	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Matured human monocyte-derived dendritic cells -LRB- MoDCs -RRB- induce expansion of CD4 + CD25 + FOXP3 + T cells lacking regulatory properties .
18298587	0	CD25	62,66	CD4	58,61	CD25	CD4	3669	920	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Observational support for an immunoregulatory role of CD3 + CD4 + CD25 + IFN-gamma + blood lymphocytes in kidney transplant recipients with good long-term graft outcome .
18304352	0	CD25	19,23	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The control of CD4 + CD25 + Foxp3 + regulatory T cell survival .
18308639	0	CD25	74,78	CD4	70,73	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGFbeta1_deficiency does not affect the generation and maintenance of CD4 + CD25 + FOXP3 + putative Treg cells , but causes their numerical inadequacy and loss of regulatory function .
18315924	0	CD25	36,40	CD4	31,34	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	development|compound|START_ENTITY development|compound|END_ENTITY	-LSB- Inhibitory Effect of CCL20 on CD4 + CD25 + regulatory T cell development in mouse thymus -RSB- .
18323802	0	CD25	144,148	CD4	140,143	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Vaccination of B-CLL patients with autologous dendritic cells can change the frequency of leukemia antigen-specific CD8 + T cells as well as CD4 + CD25 + FoxP3 + regulatory T cells toward an antileukemia response .
18328445	0	CD25	57,61	CD4	53,56	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Resveratrol induces the suppression of tumor-derived CD4 + CD25 + regulatory T cells .
18341610	0	CD25	18,22	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells inhibits local tumour growth in a mouse model of B_cell_lymphoma .
18355912	0	CD25	38,42	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of hepatitis_C-specific CD4 + CD25 + regulatory T cells after viral clearance : a mechanism to limit collateral damage ?
18360256	0	CD25	41,45	CD4	37,40	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|dep|Impact Impact|nmod|drugs drugs|nmod|+ +|compound|END_ENTITY	Impact of immunosuppressive drugs on CD4 + CD25 + FOXP3 + regulatory T cells : does in vitro evidence translate to the clinical setting ?
18388182	0	CD25	5,9	CD4	0,3	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + CD25 + Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6 .
18397268	0	CD25	77,81	CD4	73,76	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4 + CD25 + T cells .
18423565	0	CD25	57,61	CD4	52,55	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Grass pollen immunotherapy induces Foxp3-expressing CD4 + CD25 + cells in the nasal mucosa .
18431238	0	CD25	86,90	CD4	82,85	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depleting anti-CD4 monoclonal antibody -LRB- GK1 .5 -RRB- treatment : influence on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
18438410	0	CD25	77,81	CD4	73,76	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	A critical function for TGF-beta signaling in the development of natural CD4 + CD25 + Foxp3 + regulatory T cells .
18440785	0	CD25	39,43	CD4	35,38	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Defective functions of circulating CD4 + CD25 + and CD4 + CD25 - T cells in patients with chronic_ordinary_urticaria .
18453563	0	CD25	86,90	CD4	82,85	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
18462346	0	CD25	63,67	CD4	58,61	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
18469093	0	CD25	93,97	CD4	89,92	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
18477692	0	CD25	70,74	CD4	66,69	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18477692	0	CD25	90,94	CD4	86,89	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18478932	0	CD25	31,35	CD4	26,29	CD25	CD4	3559	920	Gene	Gene	detection|compound|START_ENTITY detection|compound|END_ENTITY	-LSB- Clinical significance of CD4 + CD25 + regulatory T-cells detection in tumor-draining lymph nodes of nonsmall_cell_lung_cancer patients -RSB- .
18480308	0	CD25	14,18	CD4	10,13	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD4 + CD25 + regulatory T cells inhibit osteoclastogenesis and collagen-induced_arthritis .
18480441	0	CD25	41,45	CD4	36,39	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-generated antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells control the severity of herpes simplex virus-induced ocular_immunoinflammatory_lesions .
18484654	0	CD25	36,40	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Effects of cryopreservation on CD4 + CD25 + T cells of HIV-1_infected individuals .
18485782	0	CD25	19,23	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The regulatory CD4 + CD25 + T cells have a limited role on pathogenesis of infection with Trypanosoma_cruzi .
18490730	0	CD25	15,19	CD4	11,14	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells selectively inhibit the spontaneous form of lymphopenia-induced_proliferation of naive T cells .
18493168	0	CD25	32,36	CD4	28,31	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of thymus-derived CD4 + CD25 + T cells abrogates the suppressive effects of alpha-galactosylceramide treatment on experimental_allergic_conjunctivitis .
18493981	0	CD25	40,44	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
18510697	0	CD25	44,48	CD4	40,43	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Foxp3 expression on normal and leukemic CD4 + CD25 + T cells implicated in human T-cell_leukemia_virus_type-1 is inconsistent with Treg cells .
18511516	0	CD25	19,23	CD4	15,18	HO-1	CD4	15368(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Suppression by CD4 + CD25 + regulatory T cells is dependent on expression of heme_oxygenase-1 in antigen-presenting cells .
18512811	0	CD25	17,21	CD4	12,15	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY +|appos|cells +|compound|END_ENTITY	Function of CD4 + , CD25 + Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting_cells and effector T cells .
18538611	0	CD25	23,27	CD4	19,22	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The involvement of CD4 + CD25 + T cells in the acute phase of Trypanosoma_cruzi_infection .
18557727	0	CD25	101,105	CD4	106,109	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	New insights into mechanisms of spontaneous liver transplant tolerance : the role of Foxp3-expressing CD25 + CD4 + regulatory T cells .
18559659	0	CD25	68,72	CD4	64,67	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Rapamycin monotherapy in patients with type 1 diabetes modifies CD4 + CD25 + FOXP3 + regulatory T-cells .
18563290	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decrease in CD4 + CD25 + and CD8 + CD28 + T cells in interstitial_pneumonitis associated with rheumatic_disease .
18566388	0	CD25	29,33	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18576316	0	CD25	13,17	CD4	69,72	CD25	CD4	3559	920	Gene	Gene	+|appos|START_ENTITY +|dep|sensitivity sensitivity|nmod|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
18576316	0	CD25	13,17	CD4	8,11	CD25	CD4	3559	920	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
18580479	0	CD25	28,32	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	In vitro expanded human CD4 + CD25 + regulatory T cells are potent suppressors of T-cell-mediated xenogeneic responses .
18587005	0	CD25	4,8	CD4	0,3	CD25	CD4	396814(Tax:9823)	404704(Tax:9823)	Gene	Gene	PD1|compound|START_ENTITY PD1|compound|END_ENTITY	CD4 + CD25 + FoxP3 + PD1 - regulatory T cells in acute and stable relapsing-remitting multiple_sclerosis and their modulation by therapy .
18589160	0	CD25	63,67	CD4	59,62	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Adoptive transfer of transplantation tolerance mediated by CD4 + CD25 + and CD8 + CD28 - regulatory T cells induced by anti-donor-specific T-cell vaccination .
18606654	0	CD25	47,51	CD4	83,86	CD25	CD4	3559	920	Gene	Gene	phenotype|compound|START_ENTITY phenotype|nmod|CD25 CD25|compound|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
18615246	0	CD25	67,71	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Isolation , flow cytometric analysis , and suppression assay of CD4 + CD25 + T-regulatory cells .
18627509	0	CD25	80,84	CD4	76,79	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In pregnant mice , the infection of Toxoplasma_gondii causes the decrease of CD4 + CD25 + - regulatory T cells .
18641303	0	CD25	50,54	CD4	45,48	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	differentiation|compound|START_ENTITY differentiation|nummod|END_ENTITY	IFN regulatory factor-1 negatively regulates CD4 + CD25 + regulatory T cell differentiation by repressing Foxp3 expression .
18642784	0	CD25	20,24	CD4	15,18	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	-LSB- Expression of CD4 + CD25 + CD127 -LRB- low / - -RRB- T cells in patients with systemic_lupus_erythematosus -RSB- .
18658093	0	CD25	22,26	CD4	18,21	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expanded CD4 + CD25 + Foxp3 + regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation .
18668589	0	CD25	93,97	CD4	89,92	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An early sympathetic nervous system influence exacerbates collagen-induced_arthritis via CD4 + CD25 + cells .
18681851	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + CD127lo regulatory T cells does not increase allergen-driven T cell activation .
18684927	0	CD25	65,69	CD4	60,63	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional characterization and gene expression analysis of CD4 + CD25 + regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin .
18719339	0	CD25	129,133	CD4	71,74	CD25	CD4	3559	920	Gene	Gene	circulating|nmod|START_ENTITY circulating|dobj|cells cells|nummod|END_ENTITY	Sepsis is characterized by the increases in percentages of circulating CD4 + CD25 + regulatory T cells and plasma levels of soluble CD25 .
18719339	0	CD25	75,79	CD4	71,74	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Sepsis is characterized by the increases in percentages of circulating CD4 + CD25 + regulatory T cells and plasma levels of soluble CD25 .
18723571	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	populations|compound|START_ENTITY populations|compound|END_ENTITY	CD4 + CD25 + T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener 's _ granulomatosis .
18725261	0	CD25	22,26	CD4	17,20	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The influence of CD4 + CD25 + Foxp3 + regulatory T cells on the immune response to rotavirus_infection .
18754436	0	CD25	56,60	CD4	51,54	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Identification of correlations between numbers of CD4 + CD25 + Treg cells , levels of sera anti-AChR antibodies and transfer growth factor-beta in patients with myasthenia_gravis -RSB- .
18768841	0	CD25	46,50	CD4	42,45	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-12R beta 2 promotes the development of CD4 + CD25 + regulatory T cells .
18772548	0	CD25	14,18	CD4	10,13	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell-depletion|compound|START_ENTITY cell-depletion|compound|END_ENTITY	Effect of CD4 + CD25 + T cell-depletion on acute lethal infection of mice with Trypanosoma congolense .
18775028	0	CD25	78,82	CD4	73,76	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Inhibition of phosphoantigen-mediated gammadelta T-cell proliferation by CD4 + CD25 + FoxP3 + regulatory T cells .
18778287	0	CD25	18,22	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Expansion of CD4 + CD25 + Foxp3 + T cells by bone marrow-derived dendritic cells .
18792402	0	CD25	29,33	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Resting B cells expand a CD4 + CD25 + Foxp3 + Treg population via TGF-beta3 .
18799222	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells are infected and activated during acute_FIV_infection .
18806350	0	CD25	33,37	CD4	29,32	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Relationship of frequency of CD4 + CD25 + Foxp3 + regulatory T cells with disease progression in antiretroviral-naive HIV-1_infected Chinese .
18813112	0	CD25	79,83	CD4	75,78	CD25	CD4	3559	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|suppression suppression|nmod|activation activation|nmod|END_ENTITY	In vitro suppression of xenoimmune-mediated macrophage activation by human CD4 + CD25 + regulatory T cells .
18815284	0	CD25	93,97	CD4	89,92	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Anti-CD3 prevents factor_VIII inhibitor development in hemophilia_A mice by a regulatory CD4 + CD25 + - dependent mechanism and by shifting cytokine production to favor a Th1 response .
18824533	0	CD25	108,112	CD4	103,106	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Schistosoma_mansoni antigens modulate experimental allergic_asthma in a murine model : a major role for CD4 + CD25 + Foxp3 + T cells independent of interleukin-10 .
18827184	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + CD25 + T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes , suggesting separate pathways of activation by Th1 and Th2 responses .
18832672	0	CD25	89,93	CD4	84,87	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CD47 controls the in vivo proliferation and homeostasis of peripheral CD4 + CD25 + Foxp3 + regulatory T cells that express CD103 .
18832695	0	CD25	44,48	CD4	39,42	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|nummod|+ +|compound|END_ENTITY	XCL1 enhances regulatory activities of CD4 + CD25 -LRB- high -RRB- CD127 -LRB- low / - -RRB- T cells in human allergic_asthma .
18844067	0	CD25	22,26	CD4	17,20	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	-LSB- Significance of CD4 + CD25 + CD127 -LRB- low -RRB- regulatory T cells and notch1 pathway in the pathogenesis of aplastic_anemia -RSB- .
18925576	0	CD25	61,65	CD4	57,60	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased diabetes development and decreased function of CD4 + CD25 + Treg in the absence of a functional DAP12 adaptor protein .
18928784	0	CD25	69,73	CD4	63,66	CD25	CD4	281861(Tax:9913)	407098(Tax:9913)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|nummod|END_ENTITY	Subpopulations of bovine WC1 -LRB- + -RRB- gammadelta T cells rather than CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells act as immune regulatory cells ex vivo .
18954555	0	CD25	24,28	CD4	20,23	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Deficiency of mouse CD4 + CD25 + Foxp3 + regulatory T cells in xenogeneic pig thymus-grafted nude_mice suffering from autoimmune_diseases .
18981109	0	CD25	11,15	CD4	6,9	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + Foxp3 + regulatory T cells do not constitutively express IL-35 .
18981115	0	CD25	32,36	CD4	27,30	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Imatinib_mesylate inhibits CD4 + CD25 + regulatory T cell activity and enhances active immunotherapy against BCR-ABL - _ tumors .
18981144	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells protect against T_cell-mediated_fulminant_hepatitis in a TGF-beta-dependent manner in mice .
18981159	0	CD25	100,104	CD4	95,98	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Measles_virus_infection in adults induces production of IL-10 and is associated with increased CD4 + CD25 + regulatory T cells .
18981295	0	CD25	80,84	CD4	76,79	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4 + CD25 + Foxp3 + T regulatory cells in mycobacterial_infection .
19016717	0	CD25	57,61	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dasatinib inhibits the proliferation and function of CD4 + CD25 + regulatory T cells .
19020538	0	CD25	54,58	CD4	50,53	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Kinetics , function and bone marrow trafficking of CD4 + CD25 + FOXP3 + regulatory T cells in myelodysplastic_syndromes -LRB- MDS -RRB- .
19031706	0	CD25	85,89	CD4	80,83	CD25	CD4	3559	920	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Immunosuppression induced by measles_virus in adult patients is not related to CD4 + CD25 + regulatory T cell induction -RSB- .
19034003	0	CD25	44,48	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY corrected|dobj|Foxp3 -LSB-|acl|corrected -LSB-|compound|END_ENTITY	Pancreatic islets induce CD4 -LRB- + -RRB- -LSB- corrected -RSB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- -LSB- corrected -RSB- T-cell regulated tolerance to HY-mismatched skin grafts .
19040605	0	CD25	72,76	CD4	68,71	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Recurrent superantigen exposure in vivo leads to highly suppressive CD4 + CD25 + and CD4 + CD25 - T cells with anergic and suppressive genetic signatures .
19051021	0	CD25	30,34	CD4	26,29	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|Diminution Diminution|nmod|END_ENTITY	Diminution of Circulating CD4 + CD25 high T cells in na ve Crohn 's _ disease .
19056449	0	CD25	71,75	CD4	67,70	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4 + CD25 + T regulatory cells .
19060917	0	CD25	125,129	CD4	121,124	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neonatal bacillus Calmette-Gu rin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4 + CD25 + T-regulatory cells .
19077880	0	CD25	61,65	CD4	56,59	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Hepatic stellate cells preferentially expand allogeneic CD4 + CD25 + FoxP3 + regulatory T cells in an IL-2-dependent manner .
19080493	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- The role of CD4 + CD25 + regulatory T cells in the pathogenesis of chronic abacterial_prostatitis / chronic_pelvic_pain_syndrome -RSB- .
19103952	0	CD25	19,23	CD4	15,18	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Development of CD4 + CD25 + FoxP3 + regulatory T cells from cord blood hematopoietic progenitor cells .
19104677	0	CD25	26,30	CD4	22,25	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	The role of ACAID and CD4 + CD25 + FOXP3 + regulatory T cells on CTL function against MHC alloantigens .
19134327	0	CD25	14,18	CD4	9,12	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|Role Role|nmod|END_ENTITY	-LSB- Role of CD4 + CD25 high regulatory T cells in the pathogenesis of intrahepatic_cholestasis_of_pregnancy -RSB- .
19146957	0	CD25	55,59	CD4	51,54	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The significantly enhanced frequency of functional CD4 + CD25 + Foxp3 + T regulatory cells in therapeutic dose aspirin-treated mice .
19152963	0	CD25	62,66	CD4	58,61	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Selective deregulation in chemokine signaling pathways of CD4 + CD25 -LRB- hi -RRB- CD127 -LRB- lo -RRB- / -LRB- - -RRB- regulatory T cells in human allergic_asthma .
19155973	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Upregulating CD4 + CD25 + FOXP3 + regulatory T cells in pancreatic lymph nodes in diabetic_NOD mice by adjuvant immunotherapy .
19162239	0	CD25	28,32	CD4	57,60	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY reduces|dobj|expression reduces|nmod|cells cells|compound|END_ENTITY	Bromelain treatment reduces CD25 expression on activated CD4 + T cells in vitro .
19164169	0	CD25	42,46	CD4	38,41	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	pool|compound|START_ENTITY pool|compound|END_ENTITY	Seminal fluid drives expansion of the CD4 + CD25 + T regulatory cell pool and induces tolerance to paternal alloantigens in mice .
19171090	0	CD25	18,22	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- The role of CD4 + CD25 + T cells in the mechanism of myasthenia_gravis in children and adults -RSB- .
19171501	0	CD25	134,138	CD4	130,133	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Modulation of dendritic cells using granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- delays type 1 diabetes by enhancing CD4 + CD25 + regulatory T cell function .
19173720	0	CD25	21,25	CD4	17,20	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Low frequency of CD4 + CD25 + Treg in SLE patients : a heritable trait associated with CTLA4 and TGFbeta gene variants .
19188932	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + regulatory T cell response by glatiramer_acetate in type 1 diabetes .
19190764	0	CD25	83,87	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	expressing|dobj|START_ENTITY T-lymphocytes|acl|expressing T-lymphocytes|compound|END_ENTITY	Chronic_brucellosis patients retain low frequency of CD4 + T-lymphocytes expressing CD25 and CD28 after Escherichia_coli LPS stimulation of PHA-cultured PBMCs .
19208087	0	CD25	33,37	CD4	28,31	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Chemokine responsiveness of CD4 + CD25 + regulatory and CD4 + CD25 - T cells from atopic and nonatopic donors .
19210524	0	CD25	144,148	CD4	140,143	CD25	CD4	3559	920	Gene	Gene	forkhead_box_P3|compound|START_ENTITY forkhead_box_P3|compound|END_ENTITY	Cell contact , prostaglandin_E -LRB- 2 -RRB- and transforming_growth_factor_beta_1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25 -LRB- High -RRB- forkhead_box_P3 + regulatory T cells .
19218134	0	CD25	13,17	CD4	9,12	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Role of CD4 + CD25 + Foxp3 + regulatory T cells in type 2 diabetic_nephropathy -RSB- .
19221040	0	CD25	85,89	CD4	81,84	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4 + CD25 + Foxp3 + T regulatory cells that protects against graft-versus-host_disease .
19229109	0	CD25	31,35	CD4	27,30	CD25	CD4	3559	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nummod|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
19234174	0	CD25	122,126	CD4	118,121	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human dendritic cells produce TGF-beta_1 under the influence of lung_carcinoma cells and prime the differentiation of CD4 + CD25 + Foxp3 + regulatory T cells .
19251786	0	CD25	63,67	CD4	58,61	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Local effector failure in mesothelioma is not mediated by CD4 + CD25 + T-regulator cells .
19268553	0	CD25	59,63	CD4	55,58	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Gamma irradiation alters the phenotype and function of CD4 + CD25 + regulatory T cells .
19277040	0	CD25	38,42	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
19281793	0	CD25	11,15	CD4	6,9	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Mouse CD4 + CD25 + T regulatory cells are protected from autologous complement mediated injury by Crry and CD59 .
19292855	0	CD25	32,36	CD4	28,31	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Immunomagnetic isolation of CD4 + CD25 + FoxP3 + natural T regulatory lymphocytes for clinical applications .
19303058	0	CD25	100,104	CD4	96,99	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation between the degree of immune activation , production of IL-2 and FOXP3 expression in CD4 + CD25 + T regulatory cells in HIV-1 infected persons under HAART .
19327546	0	CD25	42,46	CD4	38,41	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Feedback loop of immune regulation by CD4 + CD25 + Treg .
19342412	0	CD25	25,29	CD4	21,24	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Global impairment of CD4 + CD25 + FOXP3 + regulatory T cells in idiopathic_pulmonary_fibrosis .
19349365	0	CD25	49,53	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Surveillance of antigen-presenting cells by CD4 + CD25 + regulatory T cells in autoimmunity : immunopathogenesis and therapeutic implications .
19362679	0	CD25	65,69	CD4	61,64	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tim-3-Galectin-9 pathway involves the suppression induced by CD4 + CD25 + regulatory T cells .
19362742	0	CD25	67,71	CD4	63,66	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	CTLA4Ig_gene_transfer_alleviates_abortion in mice by expanding CD4 + CD25 + regulatory T cells and inducing indoleamine_2 ,3 - dioxygenase .
19364517	0	CD25	14,18	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + T cells in peripheral blood of celiac_disease patients : correlation with dietary treatment .
19401397	0	CD25	138,142	CD4	134,137	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intact extracellular matrix and the maintenance of immune tolerance : high molecular weight hyaluronan promotes persistence of induced CD4 + CD25 + regulatory T cells .
19410243	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Ex vivo expanded human CD4 + CD25 + Foxp3 + regulatory T cells prevent lethal xenogenic graft_versus_host_disease -LRB- GVHD -RRB- .
19438599	0	CD25	59,63	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	CD39|compound|START_ENTITY CD39|nummod|END_ENTITY	Characterization of regulatory T cells identified as CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD39 -LRB- + -RRB- in patients with active tuberculosis .
19448155	0	CD25	21,25	CD4	17,20	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
19462377	0	CD25	26,30	CD4	22,25	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19462377	0	CD25	26,30	CD4	48,51	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY required|nmod|Treg required|xcomp|control control|dobj|proliferation proliferation|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19486771	0	CD25	14,18	CD4	10,13	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + regulatory T cells in tolerance induced by portal venous injection .
19522766	0	CD25	0,4	CD4	41,44	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|acl|shedding shedding|advcl|occurring occurring|dobj|cells cells|nummod|END_ENTITY	CD25 shedding by human natural occurring CD4 + CD25 + regulatory T cells does not inhibit the action of IL-2 .
19522766	0	CD25	45,49	CD4	41,44	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	CD25 shedding by human natural occurring CD4 + CD25 + regulatory T cells does not inhibit the action of IL-2 .
19533418	0	CD25	77,81	CD4	73,76	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Low molecular weight fraction secreted by SKOV3 cells expands peripheral CD4 + CD25 + regulatory T cells and enhances their suppressive capacity .
19534876	0	CD25	31,35	CD4	26,29	CD25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- The relationship between CD4 + CD25 + regulatory T cell in the peripheral blood and poor or nonresponsiveness to hepatitis_B vaccine -RSB- .
19535644	0	CD25	121,125	CD4	117,120	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4 + CD25 + Foxp3 + T regulatory cells .
19540813	0	CD25	96,100	CD4	92,95	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Conserved anti-proliferative effect and poor inhibition of TNFalpha secretion by regulatory CD4 + CD25 + T cells in patients with systemic_lupus_erythematosus .
19545723	0	CD25	14,18	CD4	9,12	CD25	CD4	3559	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	Elevated CD4 + / CD25 + T-cell frequency and function during hepatitis_C virus recurrence after liver transplantation .
19561360	0	CD25	72,76	CD4	68,71	CD25	CD4	3559	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Docosahexaenoic_acid reduces suppressive and migratory functions of CD4 + CD25 + regulatory T-cells .
19564386	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 - T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted_fever_rickettsiosis .
19564598	0	CD25	62,66	CD4	58,61	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Secretory phospholipase A2-IID is an effector molecule of CD4 + CD25 + regulatory T cells .
19595120	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Analysis of CD4 + CD25 + Foxp3 + regulatory T cells in patients of haemorrhagic_fever_with_renal_syndrome -RSB- .
19622090	0	CD25	49,53	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Seasonal changes in suppressive capacity of CD4 + CD25 + T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25 + population .
19624523	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + T cell depletion impairs tolerance induction in a murine model of asthma .
19635903	0	CD25	110,114	CD4	38,41	CD25	CD4	3559	920	Gene	Gene	coexpression|nmod|START_ENTITY revealed|nmod|coexpression revealed|nsubj|levels levels|nmod|cells cells|compound|END_ENTITY	High levels of human antigen-specific CD4 + T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 -LRB- OX40 -RRB- .
19654865	0	CD25	63,67	CD4	58,61	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|levels levels|nmod|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
19665867	0	CD25	96,100	CD4	92,95	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4 + CD25 + Foxp3 + regulatory T cell population .
19667094	0	CD25	29,33	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Mast cells down-regulate CD4 + CD25 + T regulatory cell suppressor function via histamine H1 receptor interaction .
19667946	0	CD25	54,58	CD4	50,53	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Extracorporeal photophoresis augments function of CD4 + CD25 + FoxP3 + regulatory T cells by triggering adenosine production .
19706340	0	CD25	65,69	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naloxone can improve the anti-tumor immunity by reducing the CD4 + CD25 + Foxp3 + regulatory T cells in BALB/c mice .
19709757	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of inducible CD4 + CD25 + Foxp3 + regulatory T lymphocytes by porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- .
19715524	0	CD25	124,128	CD4	119,122	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tolerogenic semimature dendritic cells induce effector T-cell hyporesponsiveness by the activation of antigen-specific CD4 + CD25 + T-regulatory cells .
19715817	0	CD25	79,83	CD4	75,78	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin -- rather than FK506 -- might promote allograft tolerance induced by CD4 + CD25 + regulatory T cells .
19719913	0	CD25	104,108	CD4	100,103	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	-LSB- Human plasmacytoid dendritic cells from patients with chronic hepatitis_B induce the generation of CD4 + CD25 + Treg in vitro -RSB- .
19739430	0	CD25	32,36	CD4	28,31	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion of FOXP3-positive CD4 + CD25 + T cells associated with disease activity in atopic_dermatitis .
19740328	0	CD25	142,146	CD4	137,140	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4 + CD25 + Foxp3 + regulatory T cells .
19752528	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD25 bright FOXP3 + T cells are up-regulated by biological therapies and correlate with the clinical response in psoriasis patients .
19766059	0	CD25	8,12	CD4	4,7	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The CD4 + CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage .
19770521	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Tregs resolve experimental lung_injury in mice and are present in humans with acute_lung_injury .
19772948	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice .
19817769	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast_cancer model .
19833887	0	CD25	60,64	CD4	56,59	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Idd9 .1 locus controls the suppressive activity of FoxP3 + CD4 + CD25 + regulatory T-cells .
19843574	0	CD25	77,81	CD4	73,76	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Signaling through TLR7 enhances the immunosuppressive activity of murine CD4 + CD25 + T regulatory cells .
19845018	0	CD25	102,106	CD4	98,101	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4 + CD25 + Foxp3 + regulatory T cells .
19845755	0	CD25	29,33	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Absence of modulation of CD4 + CD25 regulatory T cells in CTCL patients treated with bexarotene .
19853929	0	CD25	31,35	CD4	50,53	CD25	CD4	3559	920	Gene	Gene	Conversion|nmod|START_ENTITY T|nsubj|Conversion T|nmod|CD25 CD25|compound|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19853929	0	CD25	56,60	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	T|nmod|START_ENTITY T|nsubj|Conversion Conversion|nmod|CD25 CD25|compound|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19882655	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma_japonicum is TLR2 dependent .
19900372	0	CD25	40,44	CD4	35,38	CD25	CD4	3669	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	-LSB- Association of PD-1 expression on CD4 + CD25 nt/hi CD127 lo regulatory T cells with disease progression in HIV-1_infected patients -RSB- .
19903662	0	CD25	89,93	CD4	85,88	CD25	CD4	3559	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Rapamycin , unlike cyclosporine_A , enhances suppressive functions of in vitro-induced CD4 + CD25 + Tregs .
19916283	0	CD25	131,135	CD4	126,129	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Influence of electroacupuncture and moxibustion and their treated mouse serum on the proliferation of the cultured splenetic CD4 + CD25 + regulatory T cells of tumor-bearing mice -RSB- .
19923444	0	CD25	54,58	CD4	49,52	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Activated CD8 + T-effector/memory cells eliminate CD4 + CD25 + Foxp3 + T-suppressor cells from tumors via FasL mediated apoptosis .
19946957	0	CD25	111,115	CD4	106,109	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|cell cell|nmod|methods methods|nmod|analysis analysis|nmod|END_ENTITY	Magnetic cell sorting and flow cytometry sorting methods for the isolation and function analysis of mouse CD4 + CD25 + Treg cells .
19958642	0	CD25	25,29	CD4	21,24	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Association between CD4 + CD25 + Foxp3 + regulatory T cells and serum transforming_growth_factor_beta_1 in patients with chronic_hepatitis_B -RSB- .
19961805	0	CD25	26,30	CD4	19,22	CD25	CD4	3559	920	Gene	Gene	comparison|dep|START_ENTITY comparison|nmod|END_ENTITY	-LSB- The comparison of CD4 -LRB- + -RRB- ; CD25 -LRB- high -RRB- ; Foxp3 -LRB- + -RRB- ; regulatory T cells between neonatal cord blood and adult peripheral blood . -RSB- .
19966302	0	CD25	26,30	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses .
20046022	0	CD25	88,92	CD4	84,87	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4 + CD25 + Foxp3 + cells in canine peripheral blood .
20059575	0	CD25	66,70	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	1,25-dihydroxyvitamin _ D3 enhances the ability of transferred CD4 + CD25 + cells to modulate T helper type 2-driven asthmatic responses .
20079283	0	CD25	20,24	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	inactivation|compound|START_ENTITY inactivation|compound|END_ENTITY	-LSB- The effect of CD4 + CD25 + regulatory T cell inactivation combined with levofloxacin on murine tuberculosis -RSB- .
20081380	0	CD25	64,68	CD4	59,62	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20095846	0	CD25	39,43	CD4	35,38	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Gamma-ray resistance of regulatory CD4 + CD25 + Foxp3 + T cells in mice .
20128236	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium_yoelii infection in susceptible BALB/c mice .
20137434	0	CD25	25,29	CD4	43,46	CD25	CD4	3669	920	Gene	Gene	expressions|nmod|START_ENTITY expressions|nmod|END_ENTITY	-LSB- Study on expressions of CD25 and CD127 in CD4 + peripheral T lymphocytes of patients with rheumatoid_arthritis -RSB- .
20139172	0	CD25	84,88	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
20204427	0	CD25	34,38	CD4	52,55	CD25	CD4	3559	920	Gene	Gene	characteristics|nmod|START_ENTITY characteristics|nmod|cell cell|compound|END_ENTITY	Distributional characteristics of CD25 and CD127 on CD4 + T cell subsets in chronic HCV_infection .
20230668	0	CD25	58,62	CD4	53,56	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of ConA on early activation and function of CD4 + CD25 + Treg cells in mice -RSB- .
20305583	0	CD25	82,86	CD4	78,81	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4 + CD25 + Foxp3 + regulatory T cells in allotransplantation .
20337996	0	CD25	44,48	CD4	40,43	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCL22 is involved in the recruitment of CD4 + CD25 high T cells into tuberculous pleural_effusions .
20347251	0	CD25	80,84	CD4	76,79	CD25	CD4	3559	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Is it necessary to deplete the lymphokine activated killers ' populations of CD4 + CD25 + lymphocytes ?
20357265	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia .
20357481	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + IL-10 + T cells in HDM-allergic asthmatic children with or without SIT .
20378024	0	CD25	4,8	CD4	0,3	CD25	CD4	281861(Tax:9913)	407098(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T regulatory cells are not involved in oral desensitization .
20382706	0	CD25	17,21	CD4	46,49	CD25	CD4	3559	920	Gene	Gene	IFN-gamma|compound|START_ENTITY END_ENTITY|nsubj|IFN-gamma	Antigen-specific CD25 - Foxp3 - IFN-gamma -LRB- high -RRB- CD4 + T cells restrain the development of experimental_allergic_encephalomyelitis by suppressing Th17 .
20382886	0	CD25	59,63	CD4	54,57	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20394727	0	CD25	124,128	CD4	120,123	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4 + CD25 + Foxp3 + regulatory T cells and down-regulates cardiac allograft rejection .
20412132	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + T cells switches the whey-allergic response from immunoglobulin E - to immunoglobulin free light chain-dependent .
20421648	0	CD25	43,47	CD4	37,40	CD25	CD4	3559	920	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|amod|END_ENTITY	LAG-3 expression defines a subset of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells that are expanded at tumor sites .
20448211	0	CD25	14,18	CD4	10,13	CD25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Deficient CD4 + CD25 + T regulatory cell function in patients with abdominal_aortic_aneurysms .
20463654	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice .
20487626	0	CD25	55,59	CD4	51,54	CD25	CD4	3559	920	Gene	Gene	Cells|compound|START_ENTITY Cells|nummod|END_ENTITY	IL-35 , an anti-inflammatory cytokine which expands CD4 + CD25 + Treg Cells .
20497692	0	CD25	73,77	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	converted|nmod|START_ENTITY +|ccomp|converted +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + Foxp3 + regulatory T cells converted by rapamycin from peripheral CD4 + CD25 -LRB- - -RRB- naive T cells display more potent regulatory ability in vitro .
20501849	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Selective depletion of CD4 + CD25 + Foxp3 + regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels .
20514074	0	CD25	74,78	CD4	70,73	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phenotypic and functional switch of macrophages induced by regulatory CD4 + CD25 + T cells in mice .
20522244	0	CD25	34,38	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Foxp3 regulates human natural CD4 + CD25 + regulatory T-cell-mediated suppression of xenogeneic response .
20528588	0	CD25	16,20	CD4	84,87	CD25	CD4	3559	920	Gene	Gene	defect|nmod|START_ENTITY +|nsubj|defect +|advcl|inducing inducing|nmod|cells cells|compound|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
20570629	0	CD25	132,136	CD4	77,80	CD25	CD4	3559	920	Gene	Gene	restrain|dobj|START_ENTITY mechanisms|acl:relcl|restrain mechanisms|nmod|cell cell|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20570629	0	CD25	81,85	CD4	128,131	CD25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY mechanisms|nmod|cell mechanisms|acl:relcl|restrain restrain|dobj|CD25 CD25|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20570629	0	CD25	81,85	CD4	77,80	CD25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20574434	0	CD25	51,55	CD4	47,50	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Gene regulation by 1,25-dihydroxyvitamin _ D3 in CD4 + CD25 + cells is enabled by IL-2 .
20635785	0	CD25	50,54	CD4	45,48	CD25	CD4	3559	920	Gene	Gene	patterns|parataxis|START_ENTITY patterns|nmod|+ +|compound|END_ENTITY	Expression patterns of HLA-DR + or HLA-DR - on CD4 + / CD25 + + / CD127low regulatory T cells in patients with allergy .
20646510	0	CD25	99,103	CD4	94,97	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- Effect of transcatheter_renal_arterial_embolization combined with cryoablation on regulatory CD4 + CD25 + T lymphocytes in the peripheral blood of patients with advanced renal_carcinoma -RSB- .
20650872	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + regulatory T cell depletion improves the graft-versus-tumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation .
20655262	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Decrease in CD4 + CD25 + FoxP3 + Treg cells after pulmonary resection in the treatment of cavity multidrug-resistant_tuberculosis .
20698203	0	CD25	36,40	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The variation of expression of CD4 + CD25 + Foxp3 + regulatory T cells in patients with Helicobacter_pylori_infection and eradication .
20713627	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells , dendritic cells , and circulating cytokines in uncomplicated malaria : do different parasite species elicit similar host responses ?
20723203	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppressed the indirect xenogeneic immune response mediated by porcine epithelial cell pulsed dendritic cells .
20729906	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|dobj|+ +|nsubj|END_ENTITY	CD4 + CD25 + but not CD4 + Foxp3 + T cells as a regulatory subset in primary_biliary_cirrhosis .
20801101	0	CD25	85,89	CD4	81,84	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deacetylase inhibitor trichostatin_A down-regulates Foxp3 expression and reduces CD4 + CD25 + regulatory T cells .
20844003	0	CD25	69,73	CD4	65,68	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Progesterone increases systemic and local uterine proportions of CD4 + CD25 + Treg cells during midterm pregnancy in mice .
20854875	0	CD25	25,29	CD4	20,23	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naturally occurring CD4 + CD25 + FOXP3 + T-regulatory cells are increased in chronic_myeloid_leukemia patients not in complete cytogenetic remission and can be immunosuppressive .
20858449	0	CD25	36,40	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating regulatory T cells -LRB- CD4 + CD25 + FOXP3 + -RRB- decrease in breast_cancer patients after vaccination with a modified MHC class II HER2/neu -LRB- AE37 -RRB- peptide .
20870943	0	CD25	95,99	CD4	35,38	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	induce|nmod|START_ENTITY induce|dobj|differentiation differentiation|nummod|END_ENTITY	Tolerogenic dendritic cells induce CD4 + CD25hiFoxp3 + regulatory T cell differentiation from CD4 + CD25 - / loFoxp3 - effector T cells .
20871628	0	CD25	101,105	CD4	96,99	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	2-Gy whole-body irradiation significantly alters the balance of CD4 + CD25 - T effector cells and CD4 + CD25 + Foxp3 + T regulatory cells in mice .
20875655	0	CD25	97,101	CD4	93,96	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cardiac allograft acceptance induced by blockade of CD40-CD40L costimulation is dependent on CD4 + CD25 + regulatory T cells .
20883403	0	CD25	17,21	CD4	12,15	CD25	CD4	3669	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|nummod|END_ENTITY	Circulating CD4 + CD25 high FoxP3 + T cells vary in different clinical forms of leprosy .
20888597	0	CD25	36,40	CD4	32,35	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Effects of hypertonic saline on CD4 + CD25 + Foxp3 + regulatory T cells after hemorrhagic_shock in relation to iNOS and cytokines .
20923543	0	CD25	17,21	CD4	22,25	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The frequency of CD25 + CD4 + and FOXP3 + regulatory T cells in ectopic endometrium and ectopic decidua .
20930173	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells protect the proinflammatory activation of human umbilical vein endothelial cells .
20941599	0	CD25	26,30	CD4	22,25	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Natural and induced T CD4 + CD25 + FOXP3 + regulatory T cells .
20966498	0	CD25	59,63	CD4	55,58	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- The role of stromal mast cells in the modification of CD4 + CD25 + Foxp regulatory T cells , Th17 lymphocytes and cytotoxic lymphocytes Tc1 in the development and progression of tumor -RSB- .
20977501	0	CD25	58,62	CD4	53,56	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neonatal BCG vaccination induces IL-10 production by CD4 + CD25 + T cells .
20977632	0	CD25	50,54	CD4	45,48	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of CD39 by human peripheral blood CD4 + CD25 + T cells denotes a regulatory memory phenotype .
21039425	0	CD25	40,44	CD4	35,38	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Reduced levels of both circulating CD4 + CD25 + CD127 -LRB- low/neg -RRB- and CD4 + CD8 -LRB- neg -RRB- invariant natural killer regulatory T cells in stable heart transplant recipients .
21044123	0	CD25	95,99	CD4	91,94	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	PAS-1 , an Ascaris_suum protein , modulates allergic_airway_inflammation via CD8 + y TCR + and CD4 + CD25 + FoxP3 + T cells .
21048105	0	CD25	92,96	CD4	88,91	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Methyl_gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4 + CD25 + regulatory T cells .
21059286	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- The roles of CD4 + CD25 + T regulatory cells and Foxp3 mRNA expression in the subjects with and without responses to hepatitis_B virus vaccination -RSB- .
21072213	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells depletion may attenuate the development of silica-induced lung_fibrosis in mice .
21092106	0	CD25	4,8	CD4	0,3	CD25	CD4	493953(Tax:9685)	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells from FIV + cats induce a unique anergic profile in CD8 + lymphocyte targets .
21094858	0	CD25	79,83	CD4	74,77	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Astragalus membranaceus injection delayed allograft survival related with CD4 + CD25 + regulatory T cells .
21105040	0	CD25	31,35	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated frequencies of CD4 CD25 CD127lo regulatory T cells is associated to poor prognosis in patients with acute_myeloid_leukemia .
21108468	0	CD25	5,9	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg regulate the contribution of CD8 + T-cell subsets in repopulation of the lymphopenic environment .
21115120	0	CD25	28,32	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Selective impairment of CD4 + CD25 + Foxp3 + regulatory T cells by paclitaxel is explained by Bcl-2 / Bax mediated apoptosis .
21129004	0	CD25	5,9	CD4	0,3	CD25	CD4	3669	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	CD4 + / CD25 + cells in systemic inflammation in COPD .
21134345	0	CD25	28,32	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Proportional changes of CD4 + CD25 + Foxp3 + regulatory T cells in maternal peripheral blood during pregnancy and labor at term and preterm .
21208558	0	CD25	49,53	CD4	43,46	CD25	CD4	3559	920	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|frequency frequency|nmod|+ +|compound|END_ENTITY	-LSB- Analysis of frequency of peripheral blood CD4 + ; CD25 -LRB- high -RRB- ; Tregs and CD4 + ; CD25 -LRB- low -RRB- ; T cells and expression of PD-1 in SLE and RA patients -RSB- .
21208558	0	CD25	76,80	CD4	43,46	CD25	CD4	3559	920	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|frequency frequency|nmod|+ +|compound|END_ENTITY	-LSB- Analysis of frequency of peripheral blood CD4 + ; CD25 -LRB- high -RRB- ; Tregs and CD4 + ; CD25 -LRB- low -RRB- ; T cells and expression of PD-1 in SLE and RA patients -RSB- .
21244371	0	CD25	104,108	CD4	100,103	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibitor of PI3Ky ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4 + CD25 + FoxP3 + regulatory T cells .
21249305	0	CD25	104,108	CD4	100,103	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	proliferation|compound|START_ENTITY proliferation|compound|END_ENTITY	Cyclosporin_A-treated dendritic cells may affect the outcome of organ transplantation by decreasing CD4 + CD25 + regulatory T cell proliferation .
21249500	0	CD25	59,63	CD4	54,57	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Identification , frequency , activation and function of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells in children with juvenile_idiopathic_arthritis .
21255222	0	CD25	34,38	CD4	29,32	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Novel role of aquaporin-4 in CD4 + CD25 + T regulatory cell development and severity of Parkinson 's _ disease .
21319979	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Analysis of CD4 + CD25 + Foxp3 + regulatory T cells in HIV-exposed seronegative persons and HIV-infected persons with different disease progressions .
21347662	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Depletion of CD4 + CD25 + Foxp3 + regulatory T cells with anti-CD25 antibody may exacerbate the 1,3-b-glucan-induced lung inflammatory response in mice .
21398613	0	CD25	41,45	CD4	37,40	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Impairment of regulatory capacity of CD4 + CD25 + regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves ' _ disease .
21437244	0	CD25	57,61	CD4	52,55	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracerebral human regulatory T cells : analysis of CD4 + CD25 + FOXP3 + T cells in brain_lesions and cerebrospinal fluid of multiple_sclerosis patients .
21447271	0	CD25	5,9	CD4	1,4	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- CD4 + CD25 + Foxp3 + T lymphocytes : naturally occuring regulatory T cells -RSB- .
21450832	0	CD25	18,22	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Retention of CD4 + CD25 + FoxP3 + regulatory T cells in the liver after therapy-induced hepatitis_C_virus eradication in humans .
21469094	0	CD25	116,120	CD4	111,114	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Steady state migratory RelB + langerin + dermal dendritic cells mediate peripheral induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells .
21472340	0	CD25	91,95	CD4	63,66	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Foxp3|dep|cells Foxp3|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	CD25	91,95	CD4	87,90	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21485079	0	CD25	85,89	CD4	81,84	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effect of Chinese drugs for invigorating qi and tonifying shen on expression of CD4 + CD25 + regulatory T cells in spleen and maternal-fetal interface of abortion-prone mice -RSB- .
21518973	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
21519344	0	CD25	19,23	CD4	78,81	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|cells cells|dep|stimulation stimulation|nmod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21533081	0	CD25	45,49	CD4	51,54	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TLR2-dependent induction of IL-10 and Foxp3 + CD25 + CD4 + regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo .
21557210	0	CD25	7,11	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21557210	0	CD25	7,11	CD4	46,49	CD25	CD4	3559	920	Gene	Gene	cells|amod|START_ENTITY cells|dep|population population|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21570402	0	CD25	100,104	CD4	96,99	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	A method of generating antibodies against exogenously administered self-antigen by manipulating CD4 + CD25 + regulatory T cells .
21576985	0	CD25	37,41	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Impaired Ca regulation of CD4 CD25 regulatory T cells from pediatric asthma .
21600126	0	CD25	33,37	CD4	29,32	CD25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Study of fas-mediated Foxp3 + CD4 + CD25 + Treg cell apoptosis in patients with systemic_lupus_erythematosus -RSB- .
21604971	0	CD25	76,80	CD4	64,67	CD25	CD4	3559	920	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Transfer of cell membrane components via trogocytosis occurs in CD4 + Foxp3 + CD25 + regulatory T-cell contact-dependent suppression .
21604973	0	CD25	29,33	CD4	25,28	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased frequencies of CD4 + CD25 + Foxp3 + cells and the potent CD103 + subset in peripheral lymph_nodes correlate with autoimmune_disease predisposition in some strains of mice .
21633918	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Increased frequency of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells in patients with hepatocellular_carcinoma .
21651772	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	helper|compound|START_ENTITY helper|compound|END_ENTITY	Expansion of CD4 + CD25 + helper T cells without regulatory function in smoking and COPD .
21652515	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
21664396	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	IFN-y|compound|START_ENTITY IFN-y|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFN-y + human induced T regulatory cells are induced by interferon-y and suppress alloresponses nonspecifically .
21674673	0	CD25	30,34	CD4	25,28	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Increased frequencies of CD4 + CD25 + FOXP3 + regulatory T cells in human nasal_inverted_papilloma .
21691076	0	CD25	117,121	CD4	113,116	CD25	CD4	3559	920	Gene	Gene	Forkhead_Boxp3|compound|START_ENTITY Forkhead_Boxp3|compound|END_ENTITY	Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute_lung_injury by expanding CD4 + CD25 + Forkhead_Boxp3 -LRB- FOXP3 -RRB- + regulatory T cells and balancing anti- and pro-inflammatory factors .
21702013	0	CD25	113,117	CD4	109,112	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21702013	0	CD25	113,117	CD4	39,42	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY juvenile_idiopathic_arthritis|nmod|Treg cells|amod|juvenile_idiopathic_arthritis patients|nmod|cells cells|nmod|patients suppression|dep|cells suppression|nmod|CD25 CD25|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21702013	0	CD25	43,47	CD4	109,112	CD25	CD4	3559	920	Gene	Gene	suppression|nmod|START_ENTITY suppression|dep|cells cells|nmod|patients patients|nmod|cells cells|amod|juvenile_idiopathic_arthritis juvenile_idiopathic_arthritis|nmod|Treg Treg|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21715555	0	CD25	74,78	CD4	70,73	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Uncoupling of proliferation and cytokines from suppression within the CD4 + CD25 + Foxp3 + T-cell compartment in the 1st year of human type 1 diabetes .
21726337	0	CD25	31,35	CD4	26,29	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Maternal Foxp3 expressing CD4 + CD25 + and CD4 + CD25 - regulatory T-cell populations are enriched in human early normal pregnancy decidua : a phenotypic study of paired decidual and peripheral blood samples .
21734238	0	CD25	119,123	CD4	115,118	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin and IL-2 reduce lethal acute_graft-versus-host_disease associated with increased expansion of donor type CD4 + CD25 + Foxp3 + regulatory T cells .
21744325	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + and CD4 + CD2 + high regulatory T cells in disseminated and localized forms of allergic_contact_dermatitis : relation to specific cytokines .
21749646	0	CD25	76,80	CD4	29,32	CD25	CD4	3559	920	Gene	Gene	suppression|nmod|START_ENTITY cells|amod|suppression T|nmod|cells T|nsubj|resistance resistance|nmod|memory memory|compound|END_ENTITY	Relative resistance of human CD4 -LRB- + -RRB- memory T cells to suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells .
21799858	0	CD25	107,111	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY generated|nsubj|cells +|parataxis|generated +|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21799858	0	CD25	107,111	CD4	95,98	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY generated|nsubj|cells +|parataxis|generated +|nmod|CD127 CD127|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21824530	0	CD25	87,91	CD4	82,85	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4 + CD25 + FoxP3 + T reg cells in vivo .
21829534	0	CD25	123,127	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	compartment|compound|START_ENTITY undetectable|nmod|compartment cells|acl|undetectable T|dep|cells NY-ESO-1-specific|nsubj|T NY-ESO-1-specific|advcl|circulating circulating|dobj|cells cells|nummod|END_ENTITY	NY-ESO-1-specific circulating CD4 + T cells in ovarian_cancer patients are prevalently T -LRB- H -RRB- 1 type cells undetectable in the CD25 + FOXP3 + Treg compartment .
21831456	0	CD25	22,26	CD4	18,21	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Identification of CD4 + CD25 high Foxp3 + T cells in ovine peripheral blood .
21834806	0	CD25	18,22	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Detection of CD4 + CD25 + FOXP3 + regulatory T cells in peripheral blood of patients with chronic_autoimmune_urticaria .
21843083	0	CD25	36,40	CD4	32,35	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Neem leaf glycoprotein inhibits CD4 + CD25 + Foxp3 + Tregs to restrict murine tumor growth .
21915633	0	CD25	28,32	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Behavior of circulating CD4 + CD25 + Foxp3 + regulatory T cells in colon_cancer patients undergoing surgery .
21926188	0	CD25	54,58	CD4	26,29	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY Unmasking|nmod|cells Unmasking|nmod|cells cells|compound|END_ENTITY	Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic_lupus_erythematosus .
21958749	0	CD25	54,58	CD4	50,53	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Isolation , expansion and functional assessment of CD4 + CD25 + FoxP3 + regulatory T cells and Tr1 cells from uremic patients awaiting kidney transplantation .
21958951	0	CD25	5,9	CD4	10,13	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Host CD25 + CD4 + Foxp3 + regulatory T cells primed by anti-CD137 mAbs inhibit graft-versus-host_disease .
21975289	0	CD25	19,23	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The impact of CD4 + CD25 + T cells in the tumor microenvironment of hepatocellular_carcinoma .
21982068	0	CD25	99,103	CD4	94,97	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Neutralization of interleukin-10 or transforming growth factor-b decreases the percentages of CD4 + CD25 + Foxp3 + regulatory T cells in septic mice , thereby leading to an improved survival .
21983870	0	CD25	30,34	CD4	26,29	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations of peripheral CD4 + CD25 + Foxp3 + T regulatory cells in mice with STZ-induced diabetes .
22005288	0	CD25	18,22	CD4	13,16	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
22007491	0	CD25	38,42	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of 89SrCl2 treatment on CD4 + CD25 + regulatory T cells and its Foxp3 mRNA expression in cancer patients with bone metastases -RSB- .
22019644	0	CD25	103,107	CD4	67,70	CD25	CD4	3559	920	Gene	Gene	co-expression|nmod|START_ENTITY cells|nmod|co-expression T|dobj|cells T|nsubj|assay assay|nmod|detection detection|nmod|END_ENTITY	A novel assay for detection of hepatitis_C virus-specific effector CD4 -LRB- + -RRB- T cells via co-expression of CD25 and CD134 .
22079196	0	CD25	40,44	CD4	36,39	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Foxp3 is critical for human natural CD4 + CD25 + regulatory T cells to suppress alloimmune response .
22112394	0	CD25	39,43	CD4	35,38	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IFN-b induces the proliferation of CD4 + CD25 + Foxp3 + regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple_sclerosis .
22125630	0	CD25	35,39	CD4	29,32	CD25	CD4	16184(Tax:10090)	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Partial depletion of natural CD4 CD25 regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza_A_virus infection .
22155204	0	CD25	13,17	CD4	69,72	CD25	CD4	3559	920	Gene	Gene	B|nsubj|START_ENTITY B|ccomp|suppress suppress|dobj|cells cells|compound|proliferation proliferation|nmod|T T|compound|END_ENTITY	Human CD19 -LRB- + -RRB- CD25 -LRB- high -RRB- B regulatory cells suppress proliferation of CD4 -LRB- + -RRB- T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells .
22164498	0	CD25	68,72	CD4	63,66	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of excreted/secreted antigens of Toxoplasma_gondii on CD4 + CD25 + Foxp3 + T cells and NK cells of melanoma-bearing mice -RSB- .
22178876	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells protect endothelial function impaired by oxidized low density lipoprotein via the KLF-2 transcription factor .
22197557	0	CD25	117,121	CD4	113,116	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY cells|nummod|END_ENTITY	FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4 + CD25 - responder T cells , but not CD4 + CD25 + regulatory T cells .
22211712	0	CD25	45,49	CD4	29,32	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|FoxP3 FoxP3|nummod|END_ENTITY	The immunoregulatory role of CD4 FoxP3 CD25 regulatory T cells in lungs of mice infected with Bordetella_pertussis .
22290507	0	CD25	52,56	CD4	47,50	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Epicutaneous immunization with DNP-BSA induces CD4 + CD25 + Treg cells that inhibit Tc1-mediated CS .
22310911	0	CD25	48,52	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-5 promotes induction of antigen-specific CD4 + CD25 + T regulatory cells that suppress autoimmunity .
22332874	0	CD25	17,21	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Expansion of CD4 + CD25 + FOXP3 + regulatory T cells in infants of mothers with type_1_diabetes .
22348656	0	CD25	21,25	CD4	16,19	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Distribution of CD4 + CD25 high FoxP3 + regulatory T-cells in umbilical cord blood .
22349593	0	CD25	44,48	CD4	49,52	CD25	CD4	281861(Tax:9913)	407098(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro effects of dexamethasone on bovine CD25 + CD4 + and CD25-CD4 + cells .
22367425	0	CD25	32,36	CD4	28,31	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Pachyman treatment improves CD4 + CD25 + Treg counts and serum interleukin_4 and interferon y levels in a mouse model of Kawasaki_disease .
22379819	0	CD25	99,103	CD4	95,98	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Effects of Schistosoma 22.6 kDa/26 GST molecule mixed with Sepharose 4B beads on induction of CD4 + CD25 + regulatory T cells -RSB- .
22379972	0	CD25	72,76	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	8-Methoxypsoralen plus UVA treatment increases the proportion of CLA + CD25 + CD4 + T cells in lymph nodes of K5.hTGFb1 transgenic_mice .
22445281	0	CD25	138,142	CD4	134,137	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4 + CD25 + cells .
22451020	0	CD25	98,102	CD4	92,95	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The effect of various disease-modifying anti-rheumatic drugs on the suppressive function of CD4 CD25 regulatory T cells .
22457273	0	CD25	42,46	CD4	118,121	CD25	CD4	3559	920	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|patients patients|nmod|repopulation repopulation|compound|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22502904	0	CD25	35,39	CD4	31,34	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-reg|compound|START_ENTITY T-reg|compound|END_ENTITY	Chimeric acceleration by donor CD4 + CD25 + T-reg depleted fraction in splenocyte transplantation .
22506556	0	CD25	38,42	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|nsubj|depletion depletion|nmod|END_ENTITY	In vitro selective depletion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T-cells from PBMC using anti-tac-SAP .
22521783	0	CD25	97,101	CD4	93,96	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Effect of transcatheter_renal_arterial_embolization combined with cryoablation on regulatory CD4 + CD25 + T lymphocytes in the peripheral blood of patients with advanced renal_carcinoma .
22552859	0	CD25	19,23	CD4	14,17	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + LAP + and CD4 + CD25 + Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE - / - mice .
22576630	0	CD25	107,111	CD4	103,106	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4 + CD25 + T cells in vitro .
22609353	0	CD25	68,72	CD4	60,63	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22613171	0	CD25	76,80	CD4	36,39	CD25	CD4	3559	920	Gene	Gene	frequencies|nsubj|START_ENTITY normalizing|xcomp|frequencies restores|advcl|normalizing restores|dobj|function function|compound|END_ENTITY	Opioid maintenance therapy restores CD4 + T cell function by normalizing CD4 + CD25 -LRB- high -RRB- regulatory T cell frequencies in heroin user .
22618267	0	CD25	88,92	CD4	84,87	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibition of osteoclast differentiation and matrix metalloproteinase production by CD4 + CD25 + T cells in mice .
22636320	0	CD25	86,90	CD4	82,85	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Monocyte-derived dendritic cells from breast_cancer patients are biased to induce CD4 + CD25 + Foxp3 + regulatory T cells .
22717168	0	CD25	43,47	CD4	39,42	CD25	CD4	101789606	101790140	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory T cell properties of thymic CD4 + CD25 + cells in ducks .
22727044	0	CD25	44,48	CD4	40,43	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Treatment with MOG-DNA vaccines induces CD4 + CD25 + FoxP3 + regulatory T cells and up-regulates genes with neuroprotective functions in experimental_autoimmune_encephalomyelitis .
22749980	0	CD25	16,20	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Neutrophil -- CD4 + CD25 + T regulatory cell interactions : a possible new mechanism of infectious tolerance .
22760780	0	CD25	24,28	CD4	20,23	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral_deficiency and thrombocytopenia in a murine model of immune_thrombocytopenia .
22783261	0	CD25	58,62	CD4	51,54	CD25	CD4	3559	920	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|amod|END_ENTITY	The development and immunosuppressive functions of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are under influence of the adenosine-A2A_adenosine_receptor pathway .
22791223	0	CD25	28,32	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Increased expression of CD4 + CD25 + FOXP3 + regulatory T cells correlates with Epstein-Barr_virus and has no impact on survival in patients with classical_Hodgkin_lymphoma in Brazil .
22793523	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|nummod|+ +|compound|END_ENTITY	The decreased CD4 + CD25 + FoxP3 + T cells in nonstimulated allergic_rhinitis patients sensitized to house dust mites .
22815292	0	CD25	49,53	CD4	45,48	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
22837649	0	CD25	40,44	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|amod|END_ENTITY	Apoptosis Signaling Is Altered in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T Regulatory Lymphocytes in Pre-Eclampsia .
22851544	0	CD25	97,101	CD4	93,96	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Cytokine therapy with interleukin-2 / anti-interleukin-2 monoclonal antibody complexes expands CD4 + CD25 + Foxp3 + regulatory T cells and attenuates development and progression of atherosclerosis .
22860054	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + regulatory T cell depletion modulates anxiety and depression-like behaviors in mice .
22873180	0	CD25	117,121	CD4	113,116	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic_dermatitis via generation of CD4 + CD25 + Foxp3 + T cells .
22875869	0	CD25	5,9	CD4	0,3	CD25	CD4	3669	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + High Foxp3 + regulatory T cells , B lymphocytes , and T lymphocytes in patients with acute_ITP in Assiut Children Hospital .
22884251	0	CD25	37,41	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Removal of increased circulating CD4 + CD25 + Foxp3 + regulatory T cells in patients with septic_shock using hemoperfusion with polymyxin B-immobilized fibers .
22890368	0	CD25	84,88	CD4	80,83	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Patients with early-stage myelodysplastic_syndromes show increased frequency of CD4 + CD25 + CD127 -LRB- low -RRB- regulatory T cells .
22891289	0	CD25	101,105	CD4	124,127	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nmod|CD25-FoxP3 CD25-FoxP3|nummod|+ +|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891289	0	CD25	101,105	CD4	97,100	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891772	0	CD25	53,57	CD4	71,74	CD25	CD4	3559	920	Gene	Gene	conversion|nmod|START_ENTITY modulates|dobj|conversion T|dep|modulates T|nmod|CD25 CD25|compound|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22891772	0	CD25	80,84	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	T|nmod|START_ENTITY T|dep|modulates modulates|dobj|conversion conversion|nmod|CD25 CD25|compound|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22939904	0	CD25	24,28	CD4	18,21	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|amod|END_ENTITY	In vitro-expanded CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells controls corneal allograft rejection .
22968996	0	CD25	56,60	CD4	49,52	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|amod|END_ENTITY	The role of dendritic cells in the generation of CD4 -LRB- + -RRB- CD25 -LRB- HI -RRB- Foxp3 -LRB- + -RRB- T cells induced by amino_acid copolymers .
22971347	0	CD25	39,43	CD4	33,36	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|amod|END_ENTITY	Plasmodium_chabaudi AS : distinct CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cell responses during infection in DBA/2 and BALB/c mice .
22984435	0	CD25	28,32	CD4	24,27	CD25	CD4	3559	920	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Dendritic cells control CD4 + CD25 + Treg cell suppressor function in vitro through juxtacrine delivery of IL-2 .
23000301	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg derived from hepatocellular_carcinoma mice inhibits_tumor immunity .
23019018	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
23028916	0	CD25	100,104	CD4	110,113	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23028916	0	CD25	100,104	CD4	27,30	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY function|nmod|T inhibiting|dobj|function vitro|advcl|inhibiting cells|amod|vitro expansion|nmod|cells expansion|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23041608	0	CD25	123,127	CD4	119,122	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activation of the aryl_hydrocarbon_receptor reduces the number of precursor and effector T cells , but preserves thymic CD4 + CD25 + Foxp3 + regulatory T cells .
23085944	0	CD25	86,90	CD4	80,83	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|macrophages macrophages|nmod|mice mice|nmod|END_ENTITY	Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells .
23110942	0	CD25	50,54	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|nummod|END_ENTITY	Impaired regulatory function in circulating CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- low / - -RRB- T cells in patients with myasthenia_gravis .
23121887	0	CD25	75,79	CD4	71,74	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Bee venom ameliorates ovalbumin induced allergic_asthma via modulating CD4 + CD25 + regulatory T cells in mice .
23161469	0	CD25	36,40	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
23173675	0	CD25	42,46	CD4	37,40	CD25	CD4	3669	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Quantitative reduction of peripheral CD4 + CD25 + FOXP3 + regulatory T cells in reproductive_failure after artificial_insemination_by_donor_sperm .
23178575	0	CD25	72,76	CD4	68,71	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Influence of anticancer agents on cell survival , proliferation , and CD4 + CD25 + Foxp3 + regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen .
23185797	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Treg and TGF-beta play important roles in pathogenesis of Uygur cervical_carcinoma .
23198878	0	CD25	13,17	CD4	7,10	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine CD4 CD25 cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo .
23249428	0	CD25	63,67	CD4	59,62	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Lower proportions of CD4 + CD25 -LRB- high -RRB- and CD4 + FoxP3 , but not CD4 + CD25 + CD127 -LRB- low -RRB- FoxP3 + T cell levels in children with autoimmune_thyroid_diseases .
23267787	0	CD25	56,60	CD4	52,55	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Effect of rapamycin and interleukin-2 on regulatory CD4 + CD25 + Foxp3 + T cells in mice after allogenic corneal transplantation .
23280063	0	CD25	111,115	CD4	100,103	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY +|dobj|CD127 +|dep|enhances enhances|dobj|expression expression|nmod|CD45ro CD45ro|compound|END_ENTITY	Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4 + CD45ro + CD25 + CD127 -LRB- low -RRB- regulatory T cells .
23282736	0	CD25	39,43	CD4	35,38	CD25	CD4	3559	920	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	The expression and significance of CD4 + CD25 + CD127low / - regulatory T cells and Foxp3 in patients with portal hypertension and hypersplenism .
23340699	0	CD25	14,18	CD4	8,11	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lack of CD4 CD25 FOXP3 regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki_disease .
23354908	0	CD25	36,40	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Decreased levels of circulating CD4 + CD25 + Foxp3 + regulatory T cells in patients with primary antiphospholipid_syndrome .
23450683	6	CD25	1273,1277	CD4	1269,1272	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppression assays showed that CD4 + CD25 -LRB- high -RRB- cells in patients with antibiotic-refractory arthritis did not effectively suppress proliferation of CD4 + CD25 - cells or secretion of interferon-y and tumor_necrosis_factor_a , whereas those cells in patients with antibiotic-responsive arthritis did suppress proliferation of CD4 + CD25 - cells and secretion of interferon-y and tumor_necrosis_factor_a .
23498798	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|Induction Induction|nmod|END_ENTITY	Induction of CD4 + CD25 + T cells and control of cardiac allograft rejection by CD40/CD40L costimulatory pathway blockade in mice .
23502334	0	CD25	22,26	CD4	17,20	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Sclareol reduces CD4 + CD25 + FoxP3 + Treg cells in a breast_cancer model in vivo .
23509755	0	CD25	5,9	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + FOXP3 + Treg cells induced by rSSP4 derived from T. _ cruzi amastigotes increase parasitemia in an experimental Chagas_disease model .
23614243	0	CD25	28,32	CD4	22,25	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Relationship between CD4 + CD25 + Foxp3 + regulatory T cells and Th17 responses in Chlamydia muridarum pulmonary_infection -RSB- .
23623844	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Evaluation of CD4 + CD25 + FOXP3 + regulatory T cells function in patients with common variable immunodeficiency .
23628659	0	CD25	121,125	CD4	126,129	CD25	CD4	281861(Tax:9913)	407098(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro effects of meloxicam on the number , Foxp3 expression , production of selected cytokines , and apoptosis of bovine CD25 + CD4 + and CD25-CD4 + cells .
23635849	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells attenuate lipopolysaccharide-induced systemic inflammatory responses and promotes survival in murine Escherichia_coli infection .
23648818	0	CD25	146,150	CD4	142,145	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	numbers|compound|START_ENTITY numbers|compound|END_ENTITY	Bifidobacterium infantis suppression of Peyer 's patch MIP-1a and MIP-1b secretion during Salmonella infection correlates with increased local CD4 + CD25 + T cell numbers .
23650616	0	CD25	26,30	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	proliferation|compound|START_ENTITY proliferation|compound|END_ENTITY	miR-142-3p is involved in CD25 + CD4 T cell proliferation by targeting the expression of glycoprotein_A_repetitions_predominant .
23664516	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells in the pathophysiology of immune thrombocytopenia .
23681433	0	CD25	18,22	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	time|compound|START_ENTITY time|compound|END_ENTITY	Evaluation of CD4 + CD25 + T lymphocyte response time kinetics in patients with chronic_Chagas_disease after in vitro stimulation with recombinant Trypanosoma_cruzi antigens .
23728588	0	CD25	48,52	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Analysis of circulating regulatory T cells -LRB- CD4 + CD25 + CD127 - -RRB- after cryosurgery in prostate_cancer .
23734780	0	CD25	38,42	CD4	34,37	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
23749427	0	CD25	60,64	CD4	55,58	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
23760252	0	CD25	69,73	CD4	64,67	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Infection with feline_immunodeficiency_virus directly activates CD4 + CD25 + T regulatory cells .
23776439	0	CD25	25,29	CD4	19,22	CD25	CD4	3559	920	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|amod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
23813328	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells contribute in liver_fibrosis improvement with interferon_alpha .
23817221	0	CD25	32,36	CD4	28,31	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Frequency and activation of CD4 + CD25 FoxP3 + regulatory T cells in peripheral blood from children with atopic_allergy .
23830064	0	CD25	28,32	CD4	22,25	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD19 + CD23 + B cells , CD4 + CD25 + T cells , E-selectin and interleukin-12 levels in children with steroid sensitive nephrotic_syndrome .
23881298	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 regulatory T cells and vascular_dysfunction in hypertension .
23882125	0	CD25	82,86	CD4	77,80	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4 + CD25 + Foxp3 + regulatory T-cell development in mice .
23883202	0	CD25	46,50	CD4	40,43	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Measurement of suppressor activity of T CD4 CD25 T reg cells using bromodeoxyuridine incorporation assay .
23883515	0	CD25	110,114	CD4	106,109	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The control of CD8 + T cell responses is preserved in perforin-deficient mice and released by depletion of CD4 + CD25 + regulatory T cells .
23884338	0	CD25	86,90	CD4	81,84	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4 + CD25 + Foxp3 + regulatory T cells in ischemia/reperfusion-induced acute kidney_injury .
23893806	0	CD25	41,45	CD4	37,40	CD25	CD4	3559	920	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Human mesenchymal stem cells elevate CD4 + CD25 + CD127low / - regulatory T cells of asthmatic patients via heme_oxygenase-1 .
23911408	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD25 + T regs with acetylated FoxP3 are associated with immune suppression in human leprosy .
23917832	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + T lymphocytes and regulation of the immune system : perspectives for a pathophysiological understanding of sepsis .
23949701	0	CD25	28,32	CD4	22,25	CD25	CD4	3559	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute_respiratory_distress_syndrome is associated with increased 30-day mortality .
23964278	0	CD25	20,24	CD4	77,80	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY Expression|nmod|FOXP3 T|nsubj|Expression T|dobj|Induced Induced|nmod|Stimulation Stimulation|nmod|Effectors Effectors|compound|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
23968847	0	CD25	50,54	CD4	45,48	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Influences of cerebral stent implantation on CD4 + CD25 + FOXP3 + Treg , Th1 and Th17 cells .
23971188	0	CD25	69,73	CD4	75,78	CD25	CD4	281861(Tax:9913)	407098(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dexamethasone , but not meloxicam , suppresses proliferation of bovine CD25 + CD4 + and CD25 - CD4 + T cells .
23971188	0	CD25	69,73	CD4	90,93	CD25	CD4	281861(Tax:9913)	407098(Tax:9913)	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ proliferation|dep|cells cells|compound|END_ENTITY	Dexamethasone , but not meloxicam , suppresses proliferation of bovine CD25 + CD4 + and CD25 - CD4 + T cells .
24007829	0	CD25	5,9	CD4	1,4	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY numbers|nummod|+ +|dobj|numbers +|nsubj|END_ENTITY	-LSB- CD4 + CD25 + CD127low -LRB- Treg -RRB- cell numbers in patients with allergic_rhinitis with and without immunotherapy -RSB- .
24023916	0	CD25	18,22	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells promotes CCL21-mediated antitumor immunity .
24030387	0	CD25	66,70	CD4	62,65	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mast cells suppress murine GVHD in a mechanism independent of CD4 + CD25 + regulatory T cells .
24076465	0	CD25	38,42	CD4	32,35	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|amod|END_ENTITY	Human lung fibroblasts increase CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells in co-cultured CD4 -LRB- + -RRB- lymphocytes .
24076465	0	CD25	38,42	CD4	77,80	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY T|nsubj|Foxp3 T|dobj|cells cells|nmod|lymphocytes lymphocytes|amod|co-cultured co-cultured|dep|END_ENTITY	Human lung fibroblasts increase CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells in co-cultured CD4 -LRB- + -RRB- lymphocytes .
24076591	0	CD25	52,56	CD4	48,51	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Arteether exerts antitumor activity and reduces CD4 + CD25 + FOXP3 + T-reg cells in vivo .
24119152	0	CD25	17,21	CD4	13,16	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	IFN-y blocks CD4 + CD25 + Tregs and abolishes immune privilege of minor histocompatibility mismatched corneal allografts .
24134738	0	CD25	7,11	CD4	115,118	CD25	CD4	3559	920	Gene	Gene	forkhead|nsubj|START_ENTITY forkhead|dobj|protein protein|acl:relcl|suppress suppress|dobj|expression expression|nmod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- forkhead box protein 3 -LRB- + -RRB- regulatory T lymphocytes suppress interferon-y and CD107 expression in CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells from tuberculous_pleural_effusions .
24135451	0	CD25	27,31	CD4	23,26	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An increased number of CD4 + CD25 + cells induced by an oral administration of Lactobacillus_plantarum NRIC0380 are involved in antiallergic activity .
24177275	0	CD25	123,127	CD4	118,121	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	APL-1 , an altered peptide ligand derived from human heat-shock protein 60 , selectively induces apoptosis in activated CD4 + CD25 + T cells from peripheral blood of rheumatoid_arthritis patients .
24214631	0	CD25	44,48	CD4	38,41	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	FoxP3 provides competitive fitness to CD4 CD25 T cells in leprosy patients via transcriptional regulation .
24244610	0	CD25	34,38	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24294847	0	CD25	47,51	CD4	40,43	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dobj|cells	-LSB- Apoptosis and its mechanisms of spleen CD4 CD25 regulatory T cells in severe aplastic_anemiamouse model -RSB- .
24339053	0	CD25	145,149	CD4	140,143	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
24345703	0	CD25	15,19	CD4	11,14	CD25	CD4	3669	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes of CD4 + CD25 + FOXP3 + and CD8 + CD28 - regulatory T cells in non-small_cell_lung_cancer patients undergoing surgery .
24348676	0	CD25	75,79	CD4	71,74	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Decreased CD127 expression on CD4 + T-cells and elevated frequencies of CD4 + CD25 + CD127 - T-cells in children with long-lasting type_1_diabetes .
24366217	0	CD25	162,166	CD4	156,159	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin _ D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4 CD25 Foxp3 regulatory T cells .
24368924	0	CD25	38,42	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An imbalance between frequency of CD4 + CD25 + FOXP3 + regulatory T cells and CCR4 + and CCR9 + circulating helper T cells is associated with active perennial allergic_conjunctivitis .
24405386	0	CD25	63,67	CD4	59,62	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Human adipose-derived stromal/stem cells induce functional CD4 + CD25 + FoxP3 + CD127 - regulatory T cells under low oxygen culture conditions .
24452947	0	CD25	38,42	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24454972	0	CD25	34,38	CD4	28,31	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
24476849	0	CD25	22,26	CD4	18,21	CD25	CD4	403870(Tax:9615)	403931(Tax:9615)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Serial changes of CD4 + CD25 + FoxP3 + regulatory T cell in canine model of sepsis induced by endotoxin .
24557710	0	CD25	132,136	CD4	128,131	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Narrowband ultraviolet B phototherapy ameliorates acute_graft-versus-host_disease by a mechanism involving in vivo expansion of CD4 + CD25 + Foxp3 + regulatory T cells .
24617046	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells and MMP-9 as diagnostic salivary biomarkers in oral_lichen_planus .
24646790	0	CD25	33,37	CD4	29,32	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Clinical prognostic value of CD4 + CD25 + FOXP3 + regulatory T cells in peripheral blood of Barcelona Clinic Liver_Cancer -LRB- BCLC -RRB- stage B_hepatocellular_carcinoma patients .
24702146	0	CD25	53,57	CD4	49,52	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cardiac allograft tolerance induced by isogeneic CD4 + CD25 + regulatory T cells .
24752698	0	CD25	30,34	CD4	23,26	CD25	CD4	3669	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
24797972	0	CD25	69,73	CD4	63,66	CD25	CD4	3559	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
24901172	0	CD25	36,40	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The variation of expression of CD4 + CD25 + Foxp3 + regulatory T cells in patients with Helicobacter_pylori_infection and eradication .
24904415	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
25030097	0	CD25	55,59	CD4	49,52	CD25	CD4	3559	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Comment on Adamzik et al. : An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory_distress_syndrome is associated with increased 30-day mortality .
25054604	0	CD25	127,131	CD4	121,124	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|nummod|END_ENTITY	Patients with systemic_lupus_erythematosus and secondary_antiphospholipid_syndrome have decreased numbers of circulating CD4 CD25 Foxp3 Treg and CD3 CD19 B cells .
25110149	0	CD25	44,48	CD4	40,43	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Cerebral_ischemia increases bone marrow CD4 + CD25 + FoxP3 + regulatory T cells in mice via signals from sympathetic nervous system .
25202951	0	CD25	68,72	CD4	62,65	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|nsubj|Isolation Isolation|appos|amplification amplification|nmod|END_ENTITY	-LSB- Isolation , amplification and identification of human natural CD4 CD25 regulatory T cells in vitro -RSB- .
25205548	0	CD25	36,40	CD4	30,33	CD25	CD4	3559	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Increase in the Expression of CD4 + CD25 + Lymphocytic T Cells in the Indeterminate Clinical Form of Human Chagas Disease After Stimulation With Recombinant Antigens of Trypanosoma_cruzi .
25256257	0	CD25	31,35	CD4	42,45	CD25	CD4	3559	920	Gene	Gene	/|compound|START_ENTITY Expansion|nmod|/ Expansion|dep|cells cells|nummod|END_ENTITY	Expansion of regulatory GITR + CD25 Low / - CD4 + T cells in systemic_lupus_erythematosus patients .
25293774	0	CD25	104,108	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ GVHD|nmod|expansion GVHD|dep|invariant invariant|nsubj|+ +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25293774	0	CD25	104,108	CD4	100,103	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25311400	0	CD25	27,31	CD4	21,24	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Circulating level of CD4 + CD25 + FOXP3 + T cells in patients with chronic_urticaria .
25480168	0	CD25	0,4	CD4	28,31	CD25	CD4	3559	920	Gene	Gene	identifies|nsubj|START_ENTITY identifies|dobj|subset subset|nmod|TIL TIL|compound|END_ENTITY	CD25 identifies a subset of CD4 FoxP3 TIL that are exhausted yet prognostically favorable in human ovarian_cancer .
25485946	0	CD25	96,100	CD4	30,33	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY +|nmod|Expression +|nsubj|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
25510094	0	CD25	41,45	CD4	37,40	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Studying the dynamics of the levels CD4 + CD25 + , CD4 + HLA-DR4 + and CD4 + CD95 + cells in the semen of men with oligosymptomatic forms of chronic urogenital_infection complicated infertility under the influence of fortege -RSB- .
25523632	0	CD25	31,35	CD4	17,20	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|nsubj|Extension Extension|nmod|Foxp3 Foxp3|compound|END_ENTITY	Extension of the CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- CD25 -LRB- - / low -RRB- regulatory T-cell subpopulation in type_1_diabetes_mellitus .
25539460	0	CD25	11,15	CD4	28,31	CD25	CD4	3559	920	Gene	Gene	START_ENTITY|dep|+ +|dep|CD25hiCD127 CD25hiCD127|compound|END_ENTITY	CD4 + CD45RO + CD25 - / lowCD127 + : CD4 + CD45RO + CD25hiCD127 - / low Ratio in Peripheral Blood_colon ; A Useful Biomarker to Detect Cardiac_Allograft_Vasculopathy in Heart Transplanted Patients .
25595257	0	CD25	95,99	CD4	91,94	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4 + CD25 + Foxp3 + T cells -LRB- Tregs -RRB- in a mouse study for active DNA Ab42 immunotherapy .
25742430	0	CD25	99,103	CD4	94,97	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Nicotine Ameliorates Experimental Severe Acute Pancreatitis via Enhancing Immunoregulation of CD4 + CD25 + Regulatory T Cells .
25767469	0	CD25	4,8	CD4	0,3	CD25	CD4	3559	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	CD4 + CD25 + CD127 -LRB- low -RRB- Regulatory T Cells Play Predominant Anti-Tumor Suppressive Role in Hepatitis_B_Virus-Associated Hepatocellular_Carcinoma .
25790134	0	CD25	50,54	CD4	46,49	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
25803101	0	CD25	15,19	CD4	11,14	CD25	CD4	3559	395362(Tax:9031)	Gene	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Changes of CD4 + CD25 + Cells Ratio in Immune Organs from Chickens Challenged with Infectious_Bursal_Disease_Virus Strains with Varying Virulences .
25833958	0	CD25	106,110	CD4	102,105	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4 + CD25 + FoxP3 + Treg .
25854343	0	CD25	18,22	CD4	14,17	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Inhibit|compound|START_ENTITY Inhibit|compound|END_ENTITY	Tumor-derived CD4 + CD25 + Tregs Inhibit the Maturation and Antigen-Presenting Function of Dendritic Cells .
25862675	0	CD25	24,28	CD4	20,23	CD25	CD4	3559	920	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	F protein increases CD4 + CD25 + T cell population in patients with chronic hepatitis_C .
25945787	0	CD25	35,39	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Peripheral Dendritic Cells and CD4 + CD25 + Foxp3 + Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage .
25945787	0	CD25	35,39	CD4	31,34	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Peripheral Dendritic Cells and CD4 + CD25 + Foxp3 + Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage .
25950023	0	CD25	131,135	CD4	127,130	CD25	CD4	403870(Tax:9615)	403931(Tax:9615)	Gene	Gene	CELLS|compound|START_ENTITY CELLS|compound|END_ENTITY	EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4 + CD25 + FOXP3 + REGULATORY T CELLS .
25955764	0	CD25	60,64	CD4	55,58	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Molecule|compound|START_ENTITY Molecule|compound|END_ENTITY	Deletion of Fibrinogen-like Protein 2 -LRB- FGL-2 -RRB- , a Novel CD4 + CD25 + Treg Effector Molecule , Leads to Improved Control of Echinococcus_multilocularis_Infection in Mice .
25967708	0	CD25	25,29	CD4	21,24	CD25	CD4	3559	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Relationship between CD4 + CD25 + Treg and expression of HIF-1a and Ki-67 in NSCLC patients .
25969837	0	CD25	28,32	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Increased Frequency of CD4 + CD25 + FoxP3 + T Regulatory Cells in Pulmonary_Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile .
25969999	1	CD25	63,67	CD4	59,62	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	1-induced CD4 + CD25 + regulatory T cells prevents immune response-mediated spontaneous_abortion .
26034548	0	CD25	19,23	CD4	14,17	CD25	CD4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Evaluation of CD4 + CD25 + FoxP3 + Regulatory T cells and FoxP3 and CTLA-4 gene Expression in Patients wwith Newly Diagnosed Tuberculosis in Northeast of Iran .
26063731	0	CD25	52,56	CD4	48,51	CD25	CD4	3559	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26067079	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Natural|compound|START_ENTITY Natural|compound|END_ENTITY	CD4 + CD25 + Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis_B_Virus Transgenic_Mice via Membrane-Bound TGF-b and OX40 .
26105222	1	CD25	50,54	CD4	44,47	CD25	CD4	3559	920	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|amod|apoptosis apoptosis|ccomp|altered altered|nmod|END_ENTITY	The apoptosis markers are altered in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T regulatorylymphocytes in pre-eclampsia .
26117939	0	CD25	18,22	CD4	12,15	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Changes of CD4 + CD25 + Foxp3 + regulatory T cells in the peripheral blood and their correlation with insulin resistance in different stages of prostate_cancer -RSB- .
26166019	0	CD25	40,44	CD4	36,39	CD25	CD4	3559	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26226256	0	CD25	55,59	CD4	51,54	CD25	CD4	3559	920	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Assessment of the frequency of regulatory T cells -LRB- CD4 + CD25 + CD127 - -RRB- in children with hemophilia_A : relation to factor_VIII inhibitors and disease severity .
26266813	0	CD25	27,31	CD4	23,26	CD25	CD4	3559	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Expression of PD-L1 on CD4 + CD25 + Foxp3 + Regulatory T Cells of Patients with Chronic_HBV_Infection and Its Correlation with Clinical Parameters .
26273136	0	CD25	35,39	CD4	29,32	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
26355564	0	CD25	100,104	CD4	94,97	CD25	CD4	3669	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|nummod|END_ENTITY	Overexpression of CD45RA isoforms in carriers of the C77G mutation leads to hyporeactivity of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
26452441	0	CD25	63,67	CD4	59,62	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intranasal Immunization with Heat_Shock_Protein_60 Induces CD4 + CD25 + GARP + and Type-1 Regulatory T Cells and Inhibits Early Atherosclerosis .
26517875	0	CD25	31,35	CD4	26,29	CD25	CD4	3559	920	Gene	Gene	Controlled|compound|START_ENTITY Controlled|compound|END_ENTITY	Orally-Induced Intestinal CD4 + CD25 + FoxP3 + Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic_Reactions .
26550650	0	CD25	94,98	CD4	90,93	CD25	CD4	3559	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	-LSB- CDR3 spectratyping analysis and complementary decision area 3 sequence determination for CD4 + CD25 + Tregs in patients with chronic hepatitis_B -RSB- .
26553468	0	CD25	66,70	CD4	15,18	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY responses|nmod|Foxp3 responses|nummod|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26553468	0	CD25	66,70	CD4	62,65	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26590312	0	CD25	87,91	CD4	13,16	CD25	CD4	3559	920	Gene	Gene	Cells|compound|START_ENTITY +|nmod|Cells +|nsubj|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
26590312	0	CD25	87,91	CD4	83,86	CD25	CD4	3559	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
26693907	0	CD25	23,27	CD4	19,22	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Freeze and Thaw of CD4 + CD25 + Foxp3 + Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host_Disease .
26721345	0	CD25	22,26	CD4	58,61	CD25	CD4	3559	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cell cell|compound|END_ENTITY	Enhanced pretreatment CD25 expression on peripheral blood CD4 + T cell predicts shortened survival in acute_myeloid_leukemia patients receiving induction chemotherapy .
26728371	0	CD25	119,123	CD4	94,97	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY Depressive|dep|cells Depressive|dep|differentiation differentiation|nmod|T T|compound|END_ENTITY	-LSB- Depressive effect of cigarette_smoke_extracts on dendritic cells inducing differentiation of CD4 -LRB- + -RRB- T cells into CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Tregs -RSB- .
26774852	0	CD25	131,135	CD4	125,128	CD25	CD4	3559	920	Gene	Gene	CD45RA|compound|START_ENTITY CD45RA|amod|vitro vitro|nmod|END_ENTITY	Human umbilical cord-derived mesenchymal stem cells suppress proliferation of PHA-activated lymphocytes in vitro by inducing CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD45RA -LRB- + -RRB- regulatory T cell production and modulating cytokine secretion .
26829554	0	CD25	37,41	CD4	33,36	CD25	CD4	3559	920	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
26955441	0	CD25	78,82	CD4	73,76	CD25	CD4	3559	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	The potential role of cell surface complement regulators and circulating CD4 + CD25 + T-cells in the development of autoimmune_myasthenia_gravis .
27049955	0	CD25	82,86	CD4	78,81	CD25	CD4	3559	920	Gene	Gene	Suppression|compound|START_ENTITY Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27070362	0	CD25	69,73	CD4	65,68	CD25	CD4	3559	920	Gene	Gene	CD127low|compound|START_ENTITY CD127low|compound|END_ENTITY	-LSB- The treatment by expanded ex vivo autologous regulatory T-cells CD4 + CD25 + FoxP3 + CD127low restores the balance of immune system in patients with remitting-relapsing multiple_sclerosis -RSB- .
7539635	0	CD25	72,76	CD4	48,51	CD25	CD4	3559	920	Gene	Gene	expressing|dobj|START_ENTITY expressing|nsubj|cells cells|compound|END_ENTITY	Influence of FK_506 -LRB- tacrolimus -RRB- on circulating CD4 + T cells expressing CD25 and CD45RA antigens in 19 patients with chronic_progressive_multiple_sclerosis participating in an open label drug safety trial .
7902998	0	CD25	66,70	CD4	90,93	CD25	CD4	3559	920	Gene	Gene	activation|appos|START_ENTITY activation|nmod|cells cells|compound|END_ENTITY	Gluten stimulation of coeliac mucosa in vitro induces activation -LRB- CD25 -RRB- of lamina propria CD4 + T cells and macrophages but no crypt-cell hyperplasia .
8094672	0	CD25	76,80	CD4	85,88	CD25	CD4	3559	920	Gene	Gene	activation|appos|START_ENTITY activation|nmod|cells cells|nummod|END_ENTITY	Activated T lymphocytes in the celiac lesion : non-proliferative activation -LRB- CD25 -RRB- of CD4 + alpha/beta cells in the lamina propria but proliferation -LRB- Ki-67 -RRB- of alpha/beta and gamma/delta cells in the epithelium .
8255102	0	CD25	44,48	CD4	34,37	CD25	CD4	3559	920	Gene	Gene	CD71|compound|START_ENTITY END_ENTITY|dep|CD71	Soluble CD23 and other receptors -LRB- CD4 , CD8 , CD25 , CD71 -RRB- in serum of patients with chronic_lymphocytic_leukemia .
9176107	0	CD25	82,86	CD4	61,64	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY thymocytes|nsubj|+ inhibit|parataxis|thymocytes inhibit|dobj|proliferation proliferation|nmod|CD3 CD3|compound|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
9670041	0	CD25	4,8	CD4	0,3	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin_2 production .
9885918	0	CD25	41,45	CD4	46,49	CD25	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immunologic self-tolerance maintained by CD25 + CD4 + naturally anergic and suppressive T cells : induction of autoimmune_disease by breaking their anergic/suppressive state .
12060392	0	CD25	66,70	CD44	10,14	CD25	CD44	16184(Tax:10090)	12505(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY CD4|nmod|cells variant|nmod|CD4 variant|nsubj|END_ENTITY	Transient CD44 variant isoform expression and reduction in CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- regulatory T cells in C3H/HeJ mice with alopecia areata .
17273993	0	CD25	56,60	CD44	50,54	CD25	CD44	16184(Tax:10090)	12505(Tax:10090)	Gene	Gene	gammadelta|dep|START_ENTITY gammadelta|dep|END_ENTITY	Beta-selection : abundance of TCRbeta - / gammadelta - CD44 - CD25 - -LRB- DN4 -RRB- cells in the foetal thymus .
9174611	0	CD25	69,73	CD44	75,79	CD25	CD44	3559	960	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	Fibroblast dependency during early thymocyte development maps to the CD25 + CD44 + stage and involves interactions with fibroblast matrix molecules .
9176107	0	CD25	148,152	CD44	142,146	CD25	CD44	16184(Tax:10090)	12505(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
9176107	0	CD25	82,86	CD44	76,80	CD25	CD44	16184(Tax:10090)	12505(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
15546950	0	CD25	37,41	CD62L	9,14	CD25	CD62L	16184(Tax:10090)	20343(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subpopulation|nmod|cells subpopulation|compound|END_ENTITY	Only the CD62L + subpopulation of CD4 + CD25 + regulatory T cells protects from lethal acute GVHD .
17627234	0	CD25	88,92	CD62L	104,109	CD25	CD62L	3559	6402	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4 + CD25 + GITR+F oxp3 + CD62L + functional regulatory T-cells in patients with graft-versus-host_disease .
18724229	0	CD25	48,52	CD62L	53,58	CD25	CD62L	3669	6402	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Interferon-gamma conditioning ex vivo generates CD25 + CD62L + Foxp3 + regulatory T cells that prevent allograft rejection : potential avenues for cellular therapy .
26693907	0	CD25	23,27	CD62L	73,78	CD25	CD62L	16184(Tax:10090)	20343(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Freeze|nmod|Foxp3 +|nsubj|Freeze +|nmod|Loss Loss|nmod|Expression Expression|compound|END_ENTITY	Freeze and Thaw of CD4 + CD25 + Foxp3 + Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host_Disease .
14707048	0	CD25	41,45	CD7	0,3	CD25	CD7	16184(Tax:10090)	12516(Tax:10090)	Gene	Gene	+|compound|START_ENTITY required|nmod|+ required|nsubjpass|END_ENTITY	CD7 and CD28 are required for murine CD4 + CD25 + regulatory T cell homeostasis and prevention of thyroiditis .
17615291	0	CD25	103,107	CD70	0,4	CD25	CD70	16184(Tax:10090)	21948(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells induce|dobj|expression +|ccomp|induce +|nsubj|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
23749427	0	CD25	60,64	CD73	0,4	CD25	CD73	3559	4907	Gene	Gene	cells|compound|START_ENTITY derived|nmod|cells vesicles|acl|derived expression|nmod|vesicles expression|nummod|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
11466326	0	CD25	55,59	CD8	25,28	CD25	CD8	3559	925	Gene	Gene	cells|compound|START_ENTITY control|nmod|cells control|nmod|activation activation|compound|END_ENTITY	Cutting edge : control of CD8 + T cell activation by CD4 + CD25 + immunoregulatory cells .
12421913	0	CD25	18,22	CD8	85,88	CD25	CD8	3559	925	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|prevent prevent|dobj|rejection rejection|compound|END_ENTITY	Cutting edge : CD4 + CD25 + alloantigen-specific immunoregulatory cells that can prevent CD8 + T cell-mediated graft rejection : implications for anti-CD154 immunotherapy .
14722622	0	CD25	4,8	CD8	77,80	CD25	CD8	3559	925	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|suppress suppress|dobj|rejection rejection|acl|mediated mediated|nmod|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress allograft rejection mediated by memory CD8 + T cells via a CD30-dependent mechanism .
15293135	0	CD25	16,20	CD8	11,14	CD25	CD8	3559	925	Gene	Gene	lymphocytes|compound|START_ENTITY implicated|nsubjpass|lymphocytes +|parataxis|implicated +|compound|END_ENTITY	Peripheral CD8 + / CD25 + lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune_hepatitis .
15447720	0	CD25	52,56	CD8	57,60	CD25	CD8	3559	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Correlation of psoriasis activity with abundance of CD25 + CD8 + T cells : conditions for cloning T cells from psoriatic plaques .
15600300	0	CD25	96,100	CD8	102,105	CD25	CD8	3559	925	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|dep|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
15731226	0	CD25	47,51	CD8	18,21	CD25	CD8	3559	925	Gene	Gene	response|nmod|START_ENTITY Modulation|dep|response Modulation|nmod|+ +|compound|END_ENTITY	Modulation of the CD8 + - T-cell response by CD4 + CD25 + regulatory T cells in patients with hepatitis_B_virus infection .
15968737	0	CD25	13,17	CD8	64,67	CD25	CD8	16184(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY Depletion|nmod|cells enhances|nsubj|Depletion enhances|dobj|response response|compound|END_ENTITY	Depletion of CD25 + CD4 + T cells -LRB- Tregs -RRB- enhances the HBV-specific CD8 + T cell response primed by DNA immunization .
16005184	0	CD25	15,19	CD8	43,46	CD25	CD8	3559	925	Gene	Gene	Effect|nmod|START_ENTITY +|nsubj|Effect +|nmod|function function|compound|END_ENTITY	Effect of CD4 + CD25 + regulatory T-cells on CD8 T-cell function in patients with autoimmune_hepatitis .
16167085	0	CD25	90,94	CD8	86,89	CD25	CD8	3559	925	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	TCR stimulation with modified anti-CD3 mAb expands CD8 + T cell population and induces CD8 + CD25 + Tregs .
16219576	0	CD25	19,23	CD8	44,47	CD25	CD8	3559	925	Gene	Gene	expression|nummod|START_ENTITY association|nmod|expression END_ENTITY|nsubj|association	The association of CD25 expression on donor CD8 + and CD4 + T cells with graft-versus-host disease after donor lymphocyte infusions .
16443370	0	CD25	18,22	CD8	47,50	CD25	CD8	3559	925	Gene	Gene	Treg|compound|START_ENTITY Treg|nmod|+ +|compound|END_ENTITY	The impact of CD4 + CD25 + Treg on tumor specific CD8 + T cell cytotoxicity and cancer .
16902287	8	CD25	1556,1560	CD8	1551,1554	CD25	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased numbers of pathogenic T cells -LRB- CD4 + CD25 + , CD4 + CD45RO + , CD8 + CD25 + and CD8 + CD45RO + -RRB- were shown in the dermis and epidermis , whereas CD4 + CD25 + Foxp3 + T -LRB- reg -RRB- were identified in psoriatic skin with a predilection for the upper dermis .
16982886	0	CD25	44,48	CD8	63,66	CD25	CD8	3559	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Ligation of CD80 is critical for high-level CD25 expression on CD8 + T lymphocytes .
17258077	0	CD25	51,55	CD8	45,48	CD25	CD8	3559	925	Gene	Gene	IL-2-independent|dep|START_ENTITY IL-2-independent|dep|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17898053	0	CD25	7,11	CD8	13,16	CD25	CD8	3559	925	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
18780874	0	CD25	42,46	CD8	32,35	CD25	CD8	3559	925	Gene	Gene	lymphocytes|nummod|START_ENTITY frequency|dep|lymphocytes frequency|nmod|CD28 CD28|compound|END_ENTITY	The frequency of regulatory CD3 + CD8 + CD28 - CD25 + T lymphocytes in human peripheral blood increases with age .
18953723	0	CD25	26,30	CD8	15,18	CD25	CD8	3669	925	Gene	Gene	T-lymphocytes|compound|START_ENTITY T-lymphocytes|compound|END_ENTITY	Non-regulatory CD8 + CD45RO + CD25 + T-lymphocytes may compensate for the loss of antigen-inexperienced CD8 + CD45RA + T-cells in old age .
18953723	0	CD25	26,30	CD8	99,102	CD25	CD8	3669	925	Gene	Gene	T-lymphocytes|compound|START_ENTITY compensate|nsubj|T-lymphocytes compensate|nmod|loss loss|nmod|T-cells T-cells|compound|END_ENTITY	Non-regulatory CD8 + CD45RO + CD25 + T-lymphocytes may compensate for the loss of antigen-inexperienced CD8 + CD45RA + T-cells in old age .
19022917	0	CD25	22,26	CD8	18,21	CD25	CD8	3559	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal_cancer tissue .
19966302	0	CD25	26,30	CD8	87,90	CD25	CD8	3559	925	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression controls|nsubj|regulation controls|dobj|development development|nmod|cells cells|compound|END_ENTITY	CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses .
20437560	0	CD25	13,17	CD8	8,11	CD25	CD8	3559	925	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Role of CD8 + CD25 + Foxp3 + regulatory T cells in multiple_sclerosis .
21092106	0	CD25	4,8	CD8	79,82	CD25	CD8	493953(Tax:9685)	925	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|induce induce|nmod|targets targets|compound|END_ENTITY	CD4 + CD25 + T regulatory cells from FIV + cats induce a unique anergic profile in CD8 + lymphocyte targets .
21108468	0	CD25	5,9	CD8	45,48	CD25	CD8	3559	925	Gene	Gene	Treg|compound|START_ENTITY regulate|nsubj|Treg regulate|dobj|contribution contribution|nmod|subsets subsets|compound|END_ENTITY	CD4 + CD25 + Treg regulate the contribution of CD8 + T-cell subsets in repopulation of the lymphopenic environment .
21518973	0	CD25	4,8	CD8	67,70	CD25	CD8	3559	925	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|dispensable dispensable|nmod|lung_inflammation lung_inflammation|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
21652515	0	CD25	4,8	CD8	91,94	CD25	CD8	3559	925	Gene	Gene	FoxP3|compound|START_ENTITY +|nsubj|FoxP3 +|ccomp|enhance enhance|dobj|activity activity|nmod|CD28-CTL CD28-CTL|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
22609353	0	CD25	68,72	CD8	64,67	CD25	CD8	3559	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22824748	0	CD25	21,25	CD8	17,20	CD25	CD8	3559	925	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Low frequency of CD8 + CD25 + FOXP3 -LRB- BRIGHT -RRB- T cells and FOXP3 mRNA expression in the peripheral blood of allergic_asthma patients .
24244610	0	CD25	34,38	CD8	14,17	CD25	CD8	3559	925	Gene	Gene	+|compound|START_ENTITY T|nmod|+ T|nsubj|ratios ratios|nmod|+ +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
25316133	0	CD25	41,45	CD8	37,40	CD25	CD8	3559	925	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Allergy-related changes in levels of CD8 + CD25 + FoxP3 -LRB- bright -RRB- Treg cells and FoxP3 mRNA expression in peripheral blood : the role of IL-10 or TGF-beta .
25921629	0	CD25	27,31	CD8	23,26	CD25	CD8	3559	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The relative values of CD8 + CD25 + Foxp3brigh Treg cells correlate with selected lung function parameters in asthma .
26155145	0	CD25	4,8	CD8	16,19	CD25	CD8	3559	925	Gene	Gene	START_ENTITY|appos|CD28 CD28|compound|END_ENTITY	CD4 + CD25 -LRB- high -RRB- , CD8 + CD28 - cells and thyroid autoantibodies in breast_cancer patients .
8255102	0	CD25	44,48	CD8	39,42	CD25	CD8	3559	925	Gene	Gene	CD71|compound|START_ENTITY CD4|dep|CD71 CD4|dep|END_ENTITY	Soluble CD23 and other receptors -LRB- CD4 , CD8 , CD25 , CD71 -RRB- in serum of patients with chronic_lymphocytic_leukemia .
12355442	0	CD25	78,82	CD80	60,64	CD25	CD80	3559	941	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|dobj|cells	Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25 + regulatory T cells .
15972628	0	CD25	37,41	CD95	94,98	CD25	CD95	3559	355	Gene	Gene	FoxP3|compound|START_ENTITY +|nsubj|FoxP3 +|ccomp|susceptible susceptible|nmod|END_ENTITY	In contrast to effector T cells , CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand - but not to TCR-mediated cell death .
18248531	0	CD25	33,37	CD_127	0,6	CD25	CD 127	3669	3575	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	CD_127 - and FoxP3 + expression on CD25 + CD4 + T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type_1_diabetes_mellitus patients .
11801641	0	CD25	0,4	CTLA-4	54,60	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY +|nsubj|CD4 +|dobj|immunoregulation immunoregulation|amod|END_ENTITY	CD25 + CD4 + regulatory T cells prevent graft rejection : CTLA-4 - and IL-10-dependent immunoregulation of alloresponses .
12355442	0	CD25	78,82	CTLA-4	44,50	CD25	CTLA-4	3559	1493	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ CD80|dobj|cells CD80|nsubj|Inhibition Inhibition|nmod|utilizes utilizes|compound|END_ENTITY	Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25 + regulatory T cells .
15295006	0	CD25	39,43	CTLA-4	9,15	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|dobj|cells induces|nsubj|engagement engagement|compound|END_ENTITY	Targeted CTLA-4 engagement induces CD4 + CD25 + CTLA-4high T regulatory cells with target -LRB- allo -RRB- antigen specificity .
15724061	0	CD25	0,4	CTLA-4	84,90	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|dep|cells cells|acl|exert exert|nmod|independent independent|nmod|END_ENTITY	CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells exert in vitro suppressive activity independent of CTLA-4 .
16982872	0	CD25	26,30	CTLA-4	12,18	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Blockade of CTLA-4 on CD4 + CD25 + regulatory T cells abrogates their function in vivo .
17878360	0	CD25	16,20	CTLA-4	0,6	CD25	CTLA-4	3559	1493	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CTLA-4 and CD4 + CD25 + regulatory T cells inhibit protective immunity to filarial parasites in vivo .
17911604	0	CD25	59,63	CTLA-4	23,29	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induces|dobj|+ induces|nsubj|engagement engagement|nmod|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18272926	0	CD25	31,35	CTLA-4	0,6	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	converts|dobj|START_ENTITY converts|nsubj|Ig Ig|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD25	54,58	CTLA-4	0,6	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells converts|dobj|CD25 converts|nsubj|Ig Ig|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18397268	0	CD25	77,81	CTLA-4	63,69	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4 + CD25 + T cells .
18641304	0	CD25	60,64	CTLA-4	111,117	CD25	CTLA-4	3559	1493	Gene	Gene	function|nmod|START_ENTITY function|parataxis|associated associated|nmod|expression expression|nmod|END_ENTITY	Acquisition of suppressive function by activated human CD4 + CD25 - T cells is associated with the expression of CTLA-4 not FoxP3 .
19462377	0	CD25	26,30	CTLA-4	0,6	CD25	CTLA-4	3559	1493	Gene	Gene	Treg|compound|START_ENTITY required|nmod|Treg required|nsubjpass|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
22749982	0	CD25	66,70	CTLA-4	20,26	CD25	CTLA-4	3559	1493	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|CD152 CD152|appos|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
25111463	0	CD25	39,43	CTLA-4	110,116	CD25	CTLA-4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|compound|START_ENTITY targeting|dobj|+ Breaking|advcl|targeting essential|dep|Breaking essential|nmod|effect effect|nmod|blockade blockade|compound|END_ENTITY	Breaking immune tolerance by targeting CD25 + regulatory T cells is essential for the anti-tumor effect of the CTLA-4 blockade in an HLA-DR transgenic mouse model of prostate_cancer .
15322168	0	CD25	29,33	CTLA4	34,39	CD25	CTLA4	3559	1493	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional maturation of CD4 + CD25 + CTLA4 + CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens .
16224273	0	CD25	73,77	CTLA4	78,83	CD25	CTLA4	16184(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	LF 15-0195 generates synergistic tolerance by promoting formation of CD4 + CD25 + CTLA4 + T cells .
19173720	0	CD25	21,25	CTLA4	83,88	CD25	CTLA4	3559	1493	Gene	Gene	Treg|compound|START_ENTITY frequency|nmod|Treg frequency|dep|trait trait|acl|associated associated|nmod|variants variants|compound|END_ENTITY	Low frequency of CD4 + CD25 + Treg in SLE patients : a heritable trait associated with CTLA4 and TGFbeta gene variants .
15466453	0	CD25	63,67	FOXP3	16,21	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells role|nmod|development role|nmod|END_ENTITY	Crucial role of FOXP3 in the development and function of human CD25 + CD4 + regulatory T cells .
15620457	0	CD25	48,52	FOXP3	14,19	CD25	FOXP3	3669	50943	Gene	Gene	cells|compound|START_ENTITY confined|nmod|cells confined|nsubjpass|Expression Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of FOXP3 mRNA is not confined to CD4 + CD25 + T regulatory cells in humans .
15902688	0	CD25	50,54	FOXP3	12,17	CD25	FOXP3	3559	50943	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Analysis of FOXP3 protein expression in human CD4 + CD25 + regulatory T cells at the single-cell level .
16339542	0	CD25	122,126	FOXP3	109,114	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|dobj|capacity capacity|nmod|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16645171	0	CD25	45,49	FOXP3	15,20	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16785520	0	CD25	10,14	FOXP3	0,5	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	FOXP3 + CD4 + CD25 + adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin_E2-dependent mechanism .
17142730	0	CD25	47,51	FOXP3	52,57	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients .
17258077	0	CD25	51,55	FOXP3	31,36	CD25	FOXP3	3559	50943	Gene	Gene	IL-2-independent|dep|START_ENTITY IL-2-independent|dobj|generation generation|nmod|CD4 CD4|compound|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17296785	0	CD25	61,65	FOXP3	68,73	CD25	FOXP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	WASP regulates suppressor activity of human and murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- natural regulatory T cells .
17463169	0	CD25	15,19	FOXP3	21,26	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic_anemia .
17478450	0	CD25	80,84	FOXP3	58,63	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses .
17582431	0	CD25	65,69	FOXP3	70,75	CD25	FOXP3	3669	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flow cytometry-based methods for studying signaling in human CD4 + CD25 + FOXP3 + T regulatory cells .
17916446	0	CD25	46,50	FOXP3	109,114	CD25	FOXP3	3559	50943	Gene	Gene	changes|nmod|START_ENTITY +|nsubj|changes +|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Developmental changes of FOXP3-expressing CD4 + CD25 + regulatory T cells and their impairment in patients with FOXP3 gene mutations .
18025205	0	CD25	21,25	FOXP3	26,31	CD25	FOXP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18180044	0	CD25	59,63	FOXP3	18,23	CD25	FOXP3	3559	50943	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Cloning of feline FOXP3 and detection of expression in CD4 + CD25 + regulatory T cells .
18266270	0	CD25	48,52	FOXP3	55,60	CD25	FOXP3	3559	50943	Gene	Gene	Generation|nmod|START_ENTITY END_ENTITY|nsubj|Generation	Generation of highly suppressive adaptive CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells by continuous antigen stimulation .
18270368	0	CD25	66,70	FOXP3	53,58	CD25	FOXP3	3559	50943	Gene	Gene	regulate|nmod|START_ENTITY regulate|dobj|expression expression|nmod|END_ENTITY	STAT5-signaling cytokines regulate the expression of FOXP3 in CD4 + CD25 + regulatory T cells and CD4 + CD25 - effector T cells .
18287134	0	CD25	4,8	FOXP3	9,14	CD25	FOXP3	3669	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + FOXP3 + T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple_myeloma following allogeneic stem cell transplantation .
18295349	0	CD25	79,83	FOXP3	84,89	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Matured human monocyte-derived dendritic cells -LRB- MoDCs -RRB- induce expansion of CD4 + CD25 + FOXP3 + T cells lacking regulatory properties .
18308639	0	CD25	74,78	FOXP3	79,84	CD25	FOXP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGFbeta1_deficiency does not affect the generation and maintenance of CD4 + CD25 + FOXP3 + putative Treg cells , but causes their numerical inadequacy and loss of regulatory function .
18360256	0	CD25	41,45	FOXP3	46,51	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Impact of immunosuppressive drugs on CD4 + CD25 + FOXP3 + regulatory T cells : does in vitro evidence translate to the clinical setting ?
18368594	0	CD25	62,66	FOXP3	68,73	CD25	FOXP3	3559	50943	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Regulatory T-cell depletion does not prevent emergence of new CD25 + FOXP3 + lymphocytes after antigen stimulation in culture .
18493981	0	CD25	40,44	FOXP3	66,71	CD25	FOXP3	3559	50943	Gene	Gene	cells|amod|START_ENTITY inducer|nmod|cells expressing|nsubj|inducer expressing|dobj|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
18497513	0	CD25	86,90	FOXP3	18,23	CD25	FOXP3	3559	50943	Gene	Gene	conversion|nmod|START_ENTITY +|nmod|conversion +|dobj|Cells Cells|nummod|+ +|compound|END_ENTITY	Increased CD4CD25 + FOXP3 + regulatory T Cells in cancer patients from conversion of CD4 + CD25 - T cells through tumor-derived factors .
18508492	0	CD25	13,17	FOXP3	24,29	CD25	FOXP3	3559	50943	Gene	Gene	START_ENTITY|dep|Tregs Tregs|compound|END_ENTITY	Roles of CD4 + CD25 -LRB- high -RRB- FOXP3 + Tregs in lymphomas and tumors are complex .
18606654	0	CD25	47,51	FOXP3	0,5	CD25	FOXP3	3559	50943	Gene	Gene	phenotype|compound|START_ENTITY regulates|dobj|phenotype regulates|nsubj|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
18606654	0	CD25	87,91	FOXP3	0,5	CD25	FOXP3	3559	50943	Gene	Gene	phenotype|nmod|START_ENTITY regulates|dobj|phenotype regulates|nsubj|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
19303058	0	CD25	100,104	FOXP3	76,81	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nummod|END_ENTITY	Correlation between the degree of immune activation , production of IL-2 and FOXP3 expression in CD4 + CD25 + T regulatory cells in HIV-1 infected persons under HAART .
19309551	0	CD25	12,16	FOXP3	6,11	CD25	FOXP3	3559	50943	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CXCR4 + FOXP3 + CD25 + lymphocytes accumulate in CXCL12-expressing malignant_pleural_mesothelioma .
19646767	0	CD25	83,87	FOXP3	90,95	CD25	FOXP3	3559	50943	Gene	Gene	expansion|nmod|START_ENTITY function|nmod|expansion function|nsubj|END_ENTITY	Glatiramer_acetate improves regulatory T-cell function by expansion of naive CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- CD31 -LRB- + -RRB- T-cells in patients with multiple_sclerosis .
19738030	0	CD25	45,49	FOXP3	10,15	CD25	FOXP3	3669	50943	Gene	Gene	active|nmod|START_ENTITY cells|amod|active cells|nsubj|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19738030	0	CD25	45,49	FOXP3	113,118	CD25	FOXP3	3669	50943	Gene	Gene	active|nmod|START_ENTITY cells|amod|active cells|nmod|carriers carriers|nmod|mutations mutations|compound|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19752528	0	CD25	16,20	FOXP3	28,33	CD25	FOXP3	3559	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD25 bright FOXP3 + T cells are up-regulated by biological therapies and correlate with the clinical response in psoriasis patients .
20498045	0	CD25	45,49	FOXP3	50,55	CD25	FOXP3	3559	50943	Gene	Gene	expansion|nmod|START_ENTITY +|nmod|expansion +|nsubj|END_ENTITY	In vivo expansion of naive and activated CD4 + CD25 + FOXP3 + regulatory T cell populations in interleukin-2-treated HIV patients .
20854875	0	CD25	25,29	FOXP3	31,36	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY occurring|dobj|+ increased|dep|occurring increased|nsubjpass|cells cells|compound|END_ENTITY	Naturally occurring CD4 + CD25 + FOXP3 + T-regulatory cells are increased in chronic_myeloid_leukemia patients not in complete cytogenetic remission and can be immunosuppressive .
20858449	0	CD25	36,40	FOXP3	41,46	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating regulatory T cells -LRB- CD4 + CD25 + FOXP3 + -RRB- decrease in breast_cancer patients after vaccination with a modified MHC class II HER2/neu -LRB- AE37 -RRB- peptide .
21107346	0	CD25	43,47	FOXP3	50,55	CD25	FOXP3	3559	50943	Gene	Gene	regulation|nmod|START_ENTITY Mechanisms|nmod|regulation END_ENTITY|nsubj|Mechanisms	Mechanisms of impaired regulation by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in human autoimmune_diseases .
21437244	0	CD25	57,61	FOXP3	63,68	CD25	FOXP3	3669	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracerebral human regulatory T cells : analysis of CD4 + CD25 + FOXP3 + T cells in brain_lesions and cerebrospinal fluid of multiple_sclerosis patients .
21691076	0	CD25	117,121	FOXP3	139,144	CD25	FOXP3	3559	50943	Gene	Gene	Forkhead_Boxp3|compound|START_ENTITY Forkhead_Boxp3|appos|END_ENTITY	Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute_lung_injury by expanding CD4 + CD25 + Forkhead_Boxp3 -LRB- FOXP3 -RRB- + regulatory T cells and balancing anti- and pro-inflammatory factors .
21799858	0	CD25	107,111	FOXP3	113,118	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21829534	0	CD25	123,127	FOXP3	129,134	CD25	FOXP3	3559	50943	Gene	Gene	compartment|compound|START_ENTITY compartment|compound|END_ENTITY	NY-ESO-1-specific circulating CD4 + T cells in ovarian_cancer patients are prevalently T -LRB- H -RRB- 1 type cells undetectable in the CD25 + FOXP3 + Treg compartment .
22276195	0	CD25	33,37	FOXP3	44,49	CD25	FOXP3	3559	50943	Gene	Gene	expansion|nmod|START_ENTITY +|nmod|expansion +|nsubj|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22891772	0	CD25	53,57	FOXP3	90,95	CD25	FOXP3	3559	50943	Gene	Gene	conversion|nmod|START_ENTITY modulates|dobj|conversion T|dep|modulates T|nsubj|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22891772	0	CD25	80,84	FOXP3	90,95	CD25	FOXP3	3559	50943	Gene	Gene	T|nmod|START_ENTITY T|nsubj|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
23019018	0	CD25	4,8	FOXP3	56,61	CD25	FOXP3	3559	50943	Gene	Gene	CD127|compound|START_ENTITY CD127|dep|assessment assessment|nmod|phenotype phenotype|nmod|cells cells|nummod|END_ENTITY	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
23144749	0	CD25	48,52	FOXP3	30,35	CD25	FOXP3	3559	50943	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-kB .
23340699	0	CD25	14,18	FOXP3	21,26	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lack of CD4 CD25 FOXP3 regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki_disease .
23509755	0	CD25	5,9	FOXP3	11,16	CD25	FOXP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + FOXP3 + Treg cells induced by rSSP4 derived from T. _ cruzi amastigotes increase parasitemia in an experimental Chagas_disease model .
23968847	0	CD25	50,54	FOXP3	56,61	CD25	FOXP3	3559	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Influences of cerebral stent implantation on CD4 + CD25 + FOXP3 + Treg , Th1 and Th17 cells .
23993302	0	CD25	89,93	FOXP3	23,28	CD25	FOXP3	3559	50943	Gene	Gene	occurs|nmod|START_ENTITY occurs|nsubj|depletion depletion|nmod|cells cells|amod|END_ENTITY	Selective depletion of FOXP3 -LRB- high -RRB- cells by Fas-Fas-L-induced apoptosis occurs in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - enriched populations during repeated expansion .
24076591	0	CD25	52,56	FOXP3	57,62	CD25	FOXP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Arteether exerts antitumor activity and reduces CD4 + CD25 + FOXP3 + T-reg cells in vivo .
24244610	0	CD25	34,38	FOXP3	40,45	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24345703	0	CD25	15,19	FOXP3	20,25	CD25	FOXP3	3669	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes of CD4 + CD25 + FOXP3 + and CD8 + CD28 - regulatory T cells in non-small_cell_lung_cancer patients undergoing surgery .
24368924	0	CD25	38,42	FOXP3	43,48	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An imbalance between frequency of CD4 + CD25 + FOXP3 + regulatory T cells and CCR4 + and CCR9 + circulating helper T cells is associated with active perennial allergic_conjunctivitis .
24454972	0	CD25	34,38	FOXP3	42,47	CD25	FOXP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
25205084	0	CD25	32,36	FOXP3	42,47	CD25	FOXP3	3559	50943	Gene	Gene	therapy|nmod|START_ENTITY influence|nmod|therapy cells|dep|influence cells|dep|+ +|compound|END_ENTITY	The influence of therapy on CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in systemic_lupus_erythematosus patients : a prospective study .
25485946	0	CD25	96,100	FOXP3	24,29	CD25	FOXP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY +|nmod|Expression +|nsubj|CD4 CD4|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
25655390	0	CD25	8,12	FOXP3	17,22	CD25	FOXP3	3559	50943	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	CD4 -LRB- + -RRB- , CD25 -LRB- + -RRB- , FOXP3 -LRB- + -RRB- T Regulatory Cell Levels in Obese , Asthmatic , Asthmatic_Obese , and Healthy Children .
25672298	0	CD25	31,35	FOXP3	36,41	CD25	FOXP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	T regulatory cells -LRB- TREG -RRB- -LRB- TCD4 + CD25 + FOXP3 + -RRB- distribution in the different clinical forms of leprosy and reactional states .
25950023	0	CD25	131,135	FOXP3	136,141	CD25	FOXP3	403870(Tax:9615)	491876(Tax:9615)	Gene	Gene	CELLS|compound|START_ENTITY CELLS|compound|END_ENTITY	EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4 + CD25 + FOXP3 + REGULATORY T CELLS .
26166019	0	CD25	40,44	FOXP3	45,50	CD25	FOXP3	3559	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26287664	0	CD25	42,46	FOXP3	53,58	CD25	FOXP3	3559	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Correlation of TSLP , IL-33 , and CD4 + CD25 + FOXP3 + T regulatory -LRB- Treg -RRB- in pediatric asthma .
26467610	0	CD25	90,94	FOXP3	56,61	CD25	FOXP3	3669	50943	Gene	Gene	subsets|nmod|START_ENTITY subsets|nsubj|usage usage|appos|expression expression|nmod|Treg Treg|compound|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
14662196	0	CD25	14,18	Fas-ligand	27,37	CD25	Fas-ligand	3559	356	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Evaluation of CD25 , CD152 , Fas-ligand expression in the adenoids of allergic and non-allergic children : a pilot study .
14597769	0	CD25	84,88	FoxP3	13,18	CD25	FoxP3	3559	50943	Gene	Gene	activity|nmod|START_ENTITY Induction|nmod|activity Induction|nmod|END_ENTITY	Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4 + CD25 - T cells .
15374887	0	CD25	17,21	FoxP3	65,70	CD25	FoxP3	3559	50943	Gene	Gene	START_ENTITY|dep|T T|acl:relcl|express express|dobj|protein protein|amod|END_ENTITY	Cord blood CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function .
15837817	0	CD25	74,78	FoxP3	38,43	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY coexpressing|dobj|cells shows|xcomp|coexpressing shows|dobj|END_ENTITY	Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes .
15939793	0	CD25	16,20	FoxP3	41,46	CD25	FoxP3	3559	50943	Gene	Gene	Coexpression|nmod|START_ENTITY identifies|nsubj|Coexpression identifies|dobj|cells cells|amod|END_ENTITY	Coexpression of CD25 and CD27 identifies FoxP3 + regulatory T cells in inflamed synovia .
16259008	0	CD25	45,49	FoxP3	50,55	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Genetic control of thymic development of CD4 + CD25 + FoxP3 + regulatory T lymphocytes .
17011048	0	CD25	4,8	FoxP3	9,14	CD25	FoxP3	3669	50943	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|amod|END_ENTITY	CD4 + CD25 + FoxP3 + T lymphocytes fail to suppress myelin_basic_protein-induced proliferation in patients with multiple_sclerosis .
17351648	0	CD25	91,95	FoxP3	97,102	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , not cyclosporine , permits thymic generation and peripheral preservation of CD4 + CD25 + FoxP3 + T cells .
17621372	0	CD25	34,38	FoxP3	39,44	CD25	FoxP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17898053	0	CD25	7,11	FoxP3	0,5	CD25	FoxP3	3559	50943	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
18025172	0	CD25	25,29	FoxP3	30,35	CD25	FoxP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2_and_4-1BB signaling .
18304876	0	CD25	59,63	FoxP3	64,69	CD25	FoxP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Islet antigen specific IL-10 + immune responses but not CD4 + CD25 + FoxP3 + cells at diagnosis predict glycemic control in type 1 diabetes .
18355177	0	CD25	20,24	FoxP3	25,30	CD25	FoxP3	3559	50943	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Increased number of CD25 FoxP3 regulatory T cells in oral squamous_cell_carcinomas detected by chromogenic immunohistochemical double staining .
18453563	0	CD25	86,90	FoxP3	91,96	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
18469093	0	CD25	93,97	FoxP3	98,103	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
18587005	0	CD25	4,8	FoxP3	9,14	CD25	FoxP3	396814(Tax:9823)	444998(Tax:9823)	Gene	Gene	PD1|compound|START_ENTITY PD1|compound|END_ENTITY	CD4 + CD25 + FoxP3 + PD1 - regulatory T cells in acute and stable relapsing-remitting multiple_sclerosis and their modulation by therapy .
19277040	0	CD25	38,42	FoxP3	43,48	CD25	FoxP3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
19833887	0	CD25	60,64	FoxP3	50,55	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Idd9 .1 locus controls the suppressive activity of FoxP3 + CD4 + CD25 + regulatory T-cells .
20139172	0	CD25	84,88	FoxP3	89,94	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
20487258	0	CD25	115,119	FoxP3	136,141	CD25	FoxP3	3559	50943	Gene	Gene	CD127|compound|START_ENTITY END_ENTITY|nsubj|CD127	A prospective study of T - and B-lymphocyte subpopulations , CD81 expression levels on B cells and regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- FoxP3 -LRB- + -RRB- T cells in patients with chronic_HCV_infection during pegylated interferon-alpha2a plus ribavirin treatment .
21244371	0	CD25	104,108	FoxP3	109,114	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibitor of PI3Ky ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4 + CD25 + FoxP3 + regulatory T cells .
21413939	0	CD25	92,96	FoxP3	60,65	CD25	FoxP3	3559	50943	Gene	Gene	FoxP3|compound|START_ENTITY T|nmod|FoxP3 T|dep|matures matures|dobj|forkhead_box_P3 forkhead_box_P3|appos|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21824530	0	CD25	87,91	FoxP3	93,98	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4 + CD25 + FoxP3 + T reg cells in vivo .
22211712	0	CD25	45,49	FoxP3	36,41	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The immunoregulatory role of CD4 FoxP3 CD25 regulatory T cells in lungs of mice infected with Bordetella_pertussis .
22457273	0	CD25	42,46	FoxP3	50,55	CD25	FoxP3	3559	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22522779	0	CD25	57,61	FoxP3	65,70	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY grafts|nmod|levels grafts|dobj|END_ENTITY	Allogeneic bone marrow grafts with high levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells can lead to engraftment failure .
22716916	0	CD25	5,9	FoxP3	11,16	CD25	FoxP3	3559	50943	Gene	Gene	START_ENTITY|parataxis|predominant predominant|nsubj|cells cells|amod|END_ENTITY	CD4 + CD25 - FoxP3 + regulatory cells are the predominant responding regulatory T cells after human rotavirus_infection or vaccination in gnotobiotic pigs .
22760780	0	CD25	24,28	FoxP3	29,34	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral_deficiency and thrombocytopenia in a murine model of immune_thrombocytopenia .
22891289	0	CD25	101,105	FoxP3	106,111	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
23502334	0	CD25	22,26	FoxP3	28,33	CD25	FoxP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Sclareol reduces CD4 + CD25 + FoxP3 + Treg cells in a breast_cancer model in vivo .
23911408	0	CD25	4,8	FoxP3	33,38	CD25	FoxP3	3559	50943	Gene	Gene	T|compound|START_ENTITY regs|nsubj|T regs|advcl|associated associated|nsubjpass|END_ENTITY	CD4 + CD25 + T regs with acetylated FoxP3 are associated with immune suppression in human leprosy .
24214631	0	CD25	44,48	FoxP3	0,5	CD25	FoxP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY provides|nmod|cells provides|nsubj|END_ENTITY	FoxP3 provides competitive fitness to CD4 CD25 T cells in leprosy patients via transcriptional regulation .
24405386	0	CD25	63,67	FoxP3	68,73	CD25	FoxP3	3559	50943	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Human adipose-derived stromal/stem cells induce functional CD4 + CD25 + FoxP3 + CD127 - regulatory T cells under low oxygen culture conditions .
24476849	0	CD25	22,26	FoxP3	27,32	CD25	FoxP3	403870(Tax:9615)	491876(Tax:9615)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Serial changes of CD4 + CD25 + FoxP3 + regulatory T cell in canine model of sepsis induced by endotoxin .
24904415	0	CD25	4,8	FoxP3	9,14	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
24904717	0	CD25	26,30	FoxP3	33,38	CD25	FoxP3	3559	50943	Gene	Gene	status|nmod|START_ENTITY +|nsubj|status +|dobj|END_ENTITY	Numerical status of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- and CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- regulatory T cells in multiple_sclerosis .
25293774	0	CD25	104,108	FoxP3	109,114	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25480168	0	CD25	0,4	FoxP3	34,39	CD25	FoxP3	3559	50943	Gene	Gene	identifies|nsubj|START_ENTITY identifies|dobj|subset subset|nmod|TIL TIL|compound|END_ENTITY	CD25 identifies a subset of CD4 FoxP3 TIL that are exhausted yet prognostically favorable in human ovarian_cancer .
25833958	0	CD25	106,110	FoxP3	111,116	CD25	FoxP3	3559	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4 + CD25 + FoxP3 + Treg .
26034548	0	CD25	19,23	FoxP3	25,30	CD25	FoxP3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Evaluation of CD4 + CD25 + FoxP3 + Regulatory T cells and FoxP3 and CTLA-4 gene Expression in Patients wwith Newly Diagnosed Tuberculosis in Northeast of Iran .
26270121	0	CD25	99,103	FoxP3	104,109	CD25	FoxP3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Cells|nmod|START_ENTITY Role|nmod|Cells +|nsubj|Role +|dep|Cells Cells|compound|END_ENTITY	Interleukin-28B Plays a Therapeutic Role on Mouse U14 Cervical Cancer Cells by Down-Regulating CD4 + CD25 + FoxP3 + Regulatory T Cells In Vivo .
26333292	0	CD25	19,23	FoxP3	38,43	CD25	FoxP3	3559	50943	Gene	Gene	Decrease|nmod|START_ENTITY END_ENTITY|amod|Decrease	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
26504851	0	CD25	17,21	FoxP3	38,43	CD25	FoxP3	3559	50943	Gene	Gene	IL-10|compound|START_ENTITY Expansion|nmod|IL-10 END_ENTITY|nsubj|Expansion	The Expansion of CD25 -LRB- high -RRB- IL-10 -LRB- high -RRB- FoxP3 -LRB- high -RRB- B Regulatory Cells Is in Association with SLE_Disease Activity .
26517875	0	CD25	31,35	FoxP3	37,42	CD25	FoxP3	3559	50943	Gene	Gene	Controlled|compound|START_ENTITY Controlled|compound|END_ENTITY	Orally-Induced Intestinal CD4 + CD25 + FoxP3 + Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic_Reactions .
26829554	0	CD25	37,41	FoxP3	42,47	CD25	FoxP3	3559	50943	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
27049955	0	CD25	82,86	FoxP3	87,92	CD25	FoxP3	3559	50943	Gene	Gene	Suppression|compound|START_ENTITY Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27070362	0	CD25	69,73	FoxP3	74,79	CD25	FoxP3	3559	50943	Gene	Gene	CD127low|compound|START_ENTITY CD127low|compound|END_ENTITY	-LSB- The treatment by expanded ex vivo autologous regulatory T-cells CD4 + CD25 + FoxP3 + CD127low restores the balance of immune system in patients with remitting-relapsing multiple_sclerosis -RSB- .
12612578	0	CD25	51,55	Foxp3	0,5	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells programs|dep|development programs|amod|END_ENTITY	Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells .
14676299	0	CD25	29,33	Foxp3	127,132	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|dep|cells cells|nmod|CD25 CD25|acl|+ +|nmod|induction induction|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	CD25	56,60	Foxp3	127,132	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|acl|+ +|nmod|induction induction|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15237110	0	CD25	130,134	Foxp3	124,129	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|amod|END_ENTITY	Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3 + CD25 + CD4 + regulatory T cells .
15240741	0	CD25	21,25	Foxp3	0,5	CD25	Foxp3	3559	50943	Gene	Gene	expressing|dobj|START_ENTITY END_ENTITY|xcomp|expressing	Foxp3 expressing CD4 + CD25 -LRB- high -RRB- regulatory T cells are overrepresented in human metastatic_melanoma lymph nodes and inhibit the function of infiltrating T cells .
15367216	0	CD25	55,59	Foxp3	17,22	CD25	Foxp3	3559	50943	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|cells cells|amod|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
15520045	0	CD25	18,22	Foxp3	11,16	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Control of Foxp3 + CD25 + CD4 + regulatory cell activation and function by dendritic cells .
15585848	0	CD25	0,4	Foxp3	28,33	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|generate generate|ccomp|+ +|nsubj|END_ENTITY	CD25 - T cells generate CD25 + Foxp3 + regulatory T cells by peripheral expansion .
15753206	0	CD25	44,48	Foxp3	35,40	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|amod|END_ENTITY	Homeostatic maintenance of natural Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells by interleukin _ -LRB- IL -RRB- -2 and induction of autoimmune_disease by IL-2 neutralization .
15753306	0	CD25	90,94	Foxp3	0,5	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regain|dobj|expression reservoir|acl:relcl|regain constitute|dobj|reservoir CD25|parataxis|constitute CD25|compound|END_ENTITY	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15851684	0	CD25	17,21	Foxp3	100,105	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY +|nsubj|Induction +|nmod|activation activation|nmod|END_ENTITY	Induction of CD4 + CD25 + regulatory T cells by copolymer-I through activation of transcription factor Foxp3 .
15912097	0	CD25	44,48	Foxp3	70,75	CD25	Foxp3	3559	50943	Gene	Gene	START_ENTITY|dep|cells cells|nmod|transfer transfer|amod|END_ENTITY	Regulatory T cells , derived from na ve CD4 + CD25 - T cells by in vitro Foxp3 gene transfer , can induce transplantation tolerance .
16186187	0	CD25	102,106	Foxp3	96,101	GITR	Foxp3	21936(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Treatment of advanced_tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells .
16473944	0	CD25	51,55	Foxp3	44,49	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Effective expansion of alloantigen-specific Foxp3 + CD25 + CD4 + regulatory T cells by dendritic cells during the mixed leukocyte reaction .
16698419	0	CD25	22,26	Foxp3	0,5	CD25	Foxp3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Foxp3 expressing CD4 + CD25 + and CD8 + CD28 - T regulatory cells in the peripheral blood of patients with lung_cancer and pleural_mesothelioma .
16709816	0	CD25	4,8	Foxp3	9,14	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T cells and CD4 + CD25-Foxp3 + T cells in aged mice .
16751356	0	CD25	29,33	Foxp3	34,39	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : allogeneic CD4 + CD25 + Foxp3 + T regulatory cells suppress autoimmunity while establishing transplantation tolerance .
16785516	0	CD25	58,62	Foxp3	98,103	CD25	Foxp3	3559	50943	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|parataxis|leads leads|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	G_protein-coupled_receptor_83 overexpression in naive CD4 + CD25 - T cells leads to the induction of Foxp3 + regulatory T cells in vivo .
16890606	0	CD25	0,4	Foxp3	6,11	CD25	Foxp3	16184(Tax:10090)	50943	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	CD25 + / Foxp3 + T cells regulate gastric_inflammation and Helicobacter_pylori colonization in vivo .
16903903	0	CD25	7,11	Foxp3	0,5	CD25	Foxp3	3559	50943	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Foxp3 + CD25 + CD4 + natural regulatory T cells in dominant self-tolerance and autoimmune_disease .
16903923	0	CD25	47,51	Foxp3	40,45	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Dendritic cells expand antigen-specific Foxp3 + CD25 + CD4 + regulatory T cells including suppressors of alloreactivity .
16906223	0	CD25	63,67	Foxp3	34,39	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|IFN-gamma IFN-gamma|nmod|induction induction|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16914538	0	CD25	74,78	Foxp3	79,84	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel mechanism of action for anti-thymocyte globulin : induction of CD4 + CD25 + Foxp3 + regulatory T cells .
16918694	0	CD25	96,100	Foxp3	90,95	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Sublingual tolerance induction with antigen conjugated to cholera_toxin_B subunit induces Foxp3 + CD25 + CD4 + regulatory T cells and suppresses delayed-type_hypersensitivity reactions .
16943258	0	CD25	60,64	Foxp3	65,70	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	An MHC-linked locus modulates thymic differentiation of CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
17015695	0	CD25	88,92	Foxp3	93,98	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17056509	0	CD25	30,34	Foxp3	20,25	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of Foxp3 + CD4 + CD25 + and IL-10-secreting CD4 + CD25 + T cells during cure of colitis .
17082572	0	CD25	96,100	Foxp3	101,106	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cyclophosphamide-induced type-1_diabetes in the NOD mouse is associated with a reduction of CD4 + CD25 + Foxp3 + regulatory T cells .
17114433	0	CD25	97,101	Foxp3	91,96	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Oral tolerance induction with antigen conjugated to cholera_toxin_B_subunit generates both Foxp3 + CD25 + and Foxp3-CD25 - CD4 + regulatory T cells .
17277105	0	CD25	52,56	Foxp3	72,77	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17277105	0	CD25	67,71	Foxp3	72,77	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17309822	0	CD25	70,74	Foxp3	43,48	CD25	Foxp3	3669	50943	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4 + CD25 - T lymphocytes .
17316678	0	CD25	36,40	Foxp3	41,46	CD25	Foxp3	3669	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The clonal composition of human CD4 + CD25 + Foxp3 + cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements .
17350019	0	CD25	16,20	Foxp3	22,27	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells expand during experimental Plasmodium infection but do not prevent cerebral_malaria .
17371960	0	CD25	52,56	Foxp3	58,63	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Function of the IL-2R for thymic and peripheral CD4 + CD25 + Foxp3 + T regulatory cells .
17389235	0	CD25	64,68	Foxp3	71,76	CD25	Foxp3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17428252	0	CD25	88,92	Foxp3	94,99	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Diabetes_in_non-obese diabetic mice is not associated with quantitative changes in CD4 + CD25 + Foxp3 + regulatory T cells .
17453966	0	CD25	30,34	Foxp3	46,51	CD25	Foxp3	3559	50943	Gene	Gene	enriches|nmod|START_ENTITY enriches|dobj|END_ENTITY	Rapamycin enriches for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD27 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple_sclerosis .
17545218	0	CD25	91,95	Foxp3	96,101	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17615291	0	CD25	103,107	Foxp3	42,47	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
17641007	0	CD25	94,98	Foxp3	99,104	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17684039	0	CD25	73,77	Foxp3	78,83	CD25	Foxp3	3559	50943	Gene	Gene	+|compound|START_ENTITY graft-versus-host_disease|nmod|+ END_ENTITY|amod|graft-versus-host_disease	Blockade of chronic graft-versus-host_disease by alloantigen-induced CD4 + CD25 + Foxp3 + regulatory T cells in nonlymphopenic hosts .
17687106	0	CD25	108,112	Foxp3	113,118	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4 + CD25 + Foxp3 + regulatory T cells .
17688698	0	CD25	131,135	Foxp3	68,73	CD25	Foxp3	3559	50943	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
17785792	0	CD25	57,61	Foxp3	77,82	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY transcription|nmod|cells suppression|nmod|transcription suppression|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17875988	0	CD25	25,29	Foxp3	31,36	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|acl|+ +|dobj|cells cells|amod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD25	65,69	Foxp3	31,36	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells +|dobj|cells cells|amod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17911604	0	CD25	59,63	Foxp3	64,69	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18054287	0	CD25	18,22	Foxp3	28,33	CD25	Foxp3	3559	50943	Gene	Gene	Decrease|nmod|START_ENTITY END_ENTITY|nsubj|Decrease	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and elevation of CD19 -LRB- + -RRB- BAFF-R -LRB- + -RRB- B cells and soluble ICAM-1 in myasthenia_gravis .
18056346	0	CD25	92,96	Foxp3	86,91	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3 CD25 regulatory T cells .
18159952	0	CD25	173,177	Foxp3	178,183	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Repeated 0.5-Gy gamma irradiation attenuates autoimmune_disease in MRL-lpr/lpr mice with suppression of CD3 + CD4-CD8-B220 + T-cell proliferation and with up-regulation of CD4 + CD25 + Foxp3 + regulatory T cells .
18256318	0	CD25	103,107	Foxp3	108,113	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Autologous bone marrow transplantation in autoimmune_arthritis restores immune homeostasis through CD4 + CD25 + Foxp3 + regulatory T cells .
18304352	0	CD25	19,23	Foxp3	24,29	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The control of CD4 + CD25 + Foxp3 + regulatory T cell survival .
18431238	0	CD25	86,90	Foxp3	91,96	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depleting anti-CD4 monoclonal antibody -LRB- GK1 .5 -RRB- treatment : influence on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
18462346	0	CD25	63,67	Foxp3	69,74	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
18477692	0	CD25	70,74	Foxp3	75,80	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18477692	0	CD25	70,74	Foxp3	95,100	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion/differentiation|nmod|+ IL-1|nmod|expansion/differentiation END_ENTITY|amod|IL-1	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18480441	0	CD25	41,45	Foxp3	47,52	CD25	Foxp3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-generated antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells control the severity of herpes simplex virus-induced ocular_immunoinflammatory_lesions .
18510697	0	CD25	44,48	Foxp3	0,5	CD25	Foxp3	3669	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Foxp3 expression on normal and leukemic CD4 + CD25 + T cells implicated in human T-cell_leukemia_virus_type-1 is inconsistent with Treg cells .
18566388	0	CD25	29,33	Foxp3	34,39	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18641303	0	CD25	50,54	Foxp3	104,109	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	differentiation|compound|START_ENTITY regulates|dobj|differentiation regulates|advcl|repressing repressing|dobj|expression expression|amod|END_ENTITY	IFN regulatory factor-1 negatively regulates CD4 + CD25 + regulatory T cell differentiation by repressing Foxp3 expression .
18658093	0	CD25	22,26	Foxp3	27,32	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expanded CD4 + CD25 + Foxp3 + regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation .
18792402	0	CD25	29,33	Foxp3	34,39	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Resting B cells expand a CD4 + CD25 + Foxp3 + Treg population via TGF-beta3 .
18832672	0	CD25	89,93	Foxp3	95,100	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CD47 controls the in vivo proliferation and homeostasis of peripheral CD4 + CD25 + Foxp3 + regulatory T cells that express CD103 .
18981109	0	CD25	11,15	Foxp3	17,22	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + Foxp3 + regulatory T cells do not constitutively express IL-35 .
18981295	0	CD25	80,84	Foxp3	85,90	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4 + CD25 + Foxp3 + T regulatory cells in mycobacterial_infection .
19022917	0	CD25	22,26	Foxp3	27,32	CD25	Foxp3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal_cancer tissue .
19146957	0	CD25	55,59	Foxp3	60,65	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	The significantly enhanced frequency of functional CD4 + CD25 + Foxp3 + T regulatory cells in therapeutic dose aspirin-treated mice .
19153062	0	CD25	6,10	Foxp3	53,58	CD25	Foxp3	3559	50943	Gene	Gene	CD127|nsubj|START_ENTITY CD127|dobj|cells cells|dep|express express|dobj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric_cancers progression .
19155519	0	CD25	43,47	Foxp3	49,54	CD25	Foxp3	3559	50943	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|cells cells|amod|END_ENTITY	Phenotypic and functional analysis of CD4 + CD25 - Foxp3 + T cells in patients with systemic_lupus_erythematosus .
19221040	0	CD25	85,89	Foxp3	90,95	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4 + CD25 + Foxp3 + T regulatory cells that protects against graft-versus-host_disease .
19229109	0	CD25	31,35	Foxp3	36,41	CD25	Foxp3	3559	50943	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
19234174	0	CD25	122,126	Foxp3	127,132	CD25	Foxp3	3559	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human dendritic cells produce TGF-beta_1 under the influence of lung_carcinoma cells and prime the differentiation of CD4 + CD25 + Foxp3 + regulatory T cells .
19364517	0	CD25	14,18	Foxp3	19,24	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + T cells in peripheral blood of celiac_disease patients : correlation with dietary treatment .
19448155	0	CD25	21,25	Foxp3	26,31	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
19535644	0	CD25	121,125	Foxp3	127,132	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4 + CD25 + Foxp3 + T regulatory cells .
19609976	0	CD25	48,52	Foxp3	53,58	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	numbers|nmod|START_ENTITY +|nsubj|numbers +|dobj|cells cells|amod|END_ENTITY	Increased numbers of thymic and peripheral CD4 + CD25 + Foxp3 + cells in the absence of CD5 signaling .
19665867	0	CD25	96,100	Foxp3	101,106	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4 + CD25 + Foxp3 + regulatory T cell population .
19706340	0	CD25	65,69	Foxp3	70,75	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naloxone can improve the anti-tumor immunity by reducing the CD4 + CD25 + Foxp3 + regulatory T cells in BALB/c mice .
19709757	0	CD25	27,31	Foxp3	32,37	CD25	Foxp3	3559	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of inducible CD4 + CD25 + Foxp3 + regulatory T lymphocytes by porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- .
19740328	0	CD25	142,146	Foxp3	148,153	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4 + CD25 + Foxp3 + regulatory T cells .
19770521	0	CD25	4,8	Foxp3	9,14	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Tregs resolve experimental lung_injury in mice and are present in humans with acute_lung_injury .
19841169	0	CD25	74,78	Foxp3	79,84	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Skin_melanoma development in ret transgenic_mice despite the depletion of CD25 + Foxp3 + regulatory T cells in lymphoid organs .
19845018	0	CD25	102,106	Foxp3	18,23	CD25	Foxp3	3559	50943	Gene	Gene	Foxp3|compound|START_ENTITY identifying|dobj|Foxp3 importance|acl|identifying importance|nmod|antibody antibody|amod|END_ENTITY	The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4 + CD25 + Foxp3 + regulatory T cells .
19953886	0	CD25	15,19	Foxp3	58,63	CD25	Foxp3	3559	50943	Gene	Gene	Study|nmod|START_ENTITY +|nsubj|Study +|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Study of CD4 + CD25 + regulatory T cells and expression of Foxp3 mRNA in bronchiolitis and glucocorticoid regulation -RSB- .
19961805	0	CD25	26,30	Foxp3	38,43	CD25	Foxp3	3559	50943	Gene	Gene	comparison|dep|START_ENTITY comparison|dep|END_ENTITY	-LSB- The comparison of CD4 -LRB- + -RRB- ; CD25 -LRB- high -RRB- ; Foxp3 -LRB- + -RRB- ; regulatory T cells between neonatal cord blood and adult peripheral blood . -RSB- .
20081380	0	CD25	64,68	Foxp3	70,75	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20306694	0	CD25	33,37	Foxp3	8,13	CD25	Foxp3	3559	50943	Gene	Gene	T-lymphocytes|compound|START_ENTITY +|dobj|T-lymphocytes +|nsubj|Role Role|nmod|END_ENTITY	Role of Foxp3 and regulatory CD4 + CD25 + T-lymphocytes in bronchial_asthma .
20332205	0	CD25	95,99	Foxp3	100,105	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Hepatocyte_growth_factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25 + Foxp3 + regulatory T cells .
20357481	0	CD25	17,21	Foxp3	22,27	CD25	Foxp3	3559	50943	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + IL-10 + T cells in HDM-allergic asthmatic children with or without SIT .
20378024	0	CD25	4,8	Foxp3	9,14	CD25	Foxp3	281861(Tax:9913)	506053(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T regulatory cells are not involved in oral desensitization .
20382706	0	CD25	17,21	Foxp3	23,28	CD25	Foxp3	3559	50943	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|dep|END_ENTITY	Antigen-specific CD25 - Foxp3 - IFN-gamma -LRB- high -RRB- CD4 + T cells restrain the development of experimental_allergic_encephalomyelitis by suppressing Th17 .
20382886	0	CD25	59,63	Foxp3	65,70	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20394727	0	CD25	124,128	Foxp3	129,134	CD25	Foxp3	3669	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4 + CD25 + Foxp3 + regulatory T cells and down-regulates cardiac allograft rejection .
20497692	0	CD25	73,77	Foxp3	4,9	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	converted|nmod|START_ENTITY +|ccomp|converted +|nsubj|END_ENTITY	CD4 + Foxp3 + regulatory T cells converted by rapamycin from peripheral CD4 + CD25 -LRB- - -RRB- naive T cells display more potent regulatory ability in vitro .
20522244	0	CD25	34,38	Foxp3	0,5	CD25	Foxp3	3559	50943	Gene	Gene	suppression|compound|START_ENTITY regulates|dobj|suppression regulates|nsubj|END_ENTITY	Foxp3 regulates human natural CD4 + CD25 + regulatory T-cell-mediated suppression of xenogeneic response .
20693259	0	CD25	11,15	Foxp3	16,21	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Numbers of CD25 + Foxp3 + T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients .
20713627	0	CD25	5,9	Foxp3	11,16	CD25	Foxp3	3559	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells , dendritic cells , and circulating cytokines in uncomplicated malaria : do different parasite species elicit similar host responses ?
20729905	0	CD25	44,48	Foxp3	49,54	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antigen-non-specific regulation centered on CD25 + Foxp3 + Treg cells .
20832552	0	CD25	65,69	Foxp3	76,81	CD25	Foxp3	3559	50943	Gene	Gene	development|nmod|START_ENTITY drugs|nmod|development Influence|nmod|drugs END_ENTITY|amod|Influence	Influence of immunosuppressive drugs on the development of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells in liver transplant recipients .
20848841	0	CD25	33,37	Foxp3	93,98	CD25	Foxp3	3559	50943	Gene	Gene	level|nmod|START_ENTITY Studies|nmod|level +|nsubj|Studies +|nmod|expression expression|nmod|END_ENTITY	-LSB- Studies about the level of CD4 + CD25 + regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV_infection -RSB- .
20871628	0	CD25	101,105	Foxp3	107,112	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	2-Gy whole-body irradiation significantly alters the balance of CD4 + CD25 - T effector cells and CD4 + CD25 + Foxp3 + T regulatory cells in mice .
21072213	0	CD25	4,8	Foxp3	9,14	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells depletion may attenuate the development of silica-induced lung_fibrosis in mice .
21314851	0	CD25	23,27	Foxp3	31,36	CD25	Foxp3	3559	50943	Gene	Gene	circulating|dobj|START_ENTITY T|dep|circulating T|nsubj|END_ENTITY	Low circulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- _ Foxp3 -LRB- + -RRB- T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure .
21447271	0	CD25	5,9	Foxp3	10,15	CD25	Foxp3	3559	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- CD4 + CD25 + Foxp3 + T lymphocytes : naturally occuring regulatory T cells -RSB- .
21469094	0	CD25	116,120	Foxp3	122,127	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Steady state migratory RelB + langerin + dermal dendritic cells mediate peripheral induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells .
21472340	0	CD25	91,95	Foxp3	67,72	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells END_ENTITY|dep|cells	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	CD25	91,95	Foxp3	96,101	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21519344	0	CD25	19,23	Foxp3	26,31	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|cells cells|amod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21600126	0	CD25	33,37	Foxp3	23,28	CD25	Foxp3	3559	50943	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Study of fas-mediated Foxp3 + CD4 + CD25 + Treg cell apoptosis in patients with systemic_lupus_erythematosus -RSB- .
21604971	0	CD25	76,80	Foxp3	69,74	CD25	Foxp3	3559	50943	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Transfer of cell membrane components via trogocytosis occurs in CD4 + Foxp3 + CD25 + regulatory T-cell contact-dependent suppression .
21604973	0	CD25	29,33	Foxp3	34,39	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Decreased frequencies of CD4 + CD25 + Foxp3 + cells and the potent CD103 + subset in peripheral lymph_nodes correlate with autoimmune_disease predisposition in some strains of mice .
21726337	0	CD25	31,35	Foxp3	9,14	CD25	Foxp3	3669	50943	Gene	Gene	+|compound|START_ENTITY expressing|dobj|+ END_ENTITY|acl|expressing	Maternal Foxp3 expressing CD4 + CD25 + and CD4 + CD25 - regulatory T-cell populations are enriched in human early normal pregnancy decidua : a phenotypic study of paired decidual and peripheral blood samples .
21734238	0	CD25	119,123	Foxp3	124,129	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin and IL-2 reduce lethal acute_graft-versus-host_disease associated with increased expansion of donor type CD4 + CD25 + Foxp3 + regulatory T cells .
21843083	0	CD25	36,40	Foxp3	41,46	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Neem leaf glycoprotein inhibits CD4 + CD25 + Foxp3 + Tregs to restrict murine tumor growth .
21983870	0	CD25	30,34	Foxp3	35,40	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations of peripheral CD4 + CD25 + Foxp3 + T regulatory cells in mice with STZ-induced diabetes .
22005288	0	CD25	18,22	Foxp3	24,29	CD25	Foxp3	3669	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
22079196	0	CD25	40,44	Foxp3	0,5	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY critical|nmod|cells critical|nsubj|END_ENTITY	Foxp3 is critical for human natural CD4 + CD25 + regulatory T cells to suppress alloimmune response .
22098165	0	CD25	14,18	Foxp3	0,5	CD25	Foxp3	3559	50943	Gene	Gene	START_ENTITY|nsubj|CD4 CD4|compound|END_ENTITY	Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells are increased in patients with Coxiella_burnetii_endocarditis .
22164498	0	CD25	68,72	Foxp3	74,79	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of excreted/secreted antigens of Toxoplasma_gondii on CD4 + CD25 + Foxp3 + T cells and NK cells of melanoma-bearing mice -RSB- .
22564624	0	CD25	80,84	Foxp3	88,93	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cell|nmod|START_ENTITY cytotoxicity|nmod|cell Inhibition|nmod|cytotoxicity END_ENTITY|nsubj|Inhibition	Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4 CD25 Foxp3 regulatory T cells in vitro .
22609353	0	CD25	68,72	Foxp3	73,78	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22672991	0	CD25	6,10	Foxp3	0,5	CD25	Foxp3	3559	50943	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Foxp3 + CD25 -LRB- high -RRB- CD4 + regulatory T cells from indeterminate patients with Chagas_disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity .
22749982	0	CD25	66,70	Foxp3	54,59	CD25	Foxp3	3559	50943	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22873180	0	CD25	117,121	Foxp3	122,127	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic_dermatitis via generation of CD4 + CD25 + Foxp3 + T cells .
22921804	0	CD25	30,34	Foxp3	37,42	CD25	Foxp3	3559	50943	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Increased proportion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells during early-stage sepsis in ICU patients .
23017670	0	CD25	5,9	Foxp3	11,16	CD25	Foxp3	3669	50943	Gene	Gene	START_ENTITY|acl:relcl|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
23041608	0	CD25	123,127	Foxp3	128,133	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activation of the aryl_hydrocarbon_receptor reduces the number of precursor and effector T cells , but preserves thymic CD4 + CD25 + Foxp3 + regulatory T cells .
23059841	0	CD25	76,80	Foxp3	0,5	CD25	Foxp3	281861(Tax:9913)	506053(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY intensity|nmod|expression associated|nmod|intensity associated|nsubjpass|expression expression|amod|END_ENTITY	Foxp3 expression in bovine CD8 + T cells is associated with the intensity of CD25 expression .
23185797	0	CD25	4,8	Foxp3	9,14	CD25	Foxp3	3559	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Treg and TGF-beta play important roles in pathogenesis of Uygur cervical_carcinoma .
23421612	0	CD25	31,35	Foxp3	36,41	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased bronchial density of CD25 + Foxp3 + regulatory T cells in occupational asthma : relationship to current smoking .
23559897	0	CD25	68,72	Foxp3	54,59	CD25	Foxp3	3669	50943	Gene	Gene	Activity|dep|START_ENTITY Activity|nmod|END_ENTITY	Ribavirin Does Not Impair the Suppressive Activity of Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Regulatory T Cells .
23734780	0	CD25	38,42	Foxp3	43,48	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
23749427	0	CD25	60,64	Foxp3	66,71	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
23881298	0	CD25	4,8	Foxp3	9,14	CD25	Foxp3	3559	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	CD4 + CD25 + Foxp3 regulatory T cells and vascular_dysfunction in hypertension .
23949701	0	CD25	28,32	Foxp3	35,40	CD25	Foxp3	3559	50943	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute_respiratory_distress_syndrome is associated with increased 30-day mortality .
24339053	0	CD25	145,149	Foxp3	151,156	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
24366217	0	CD25	162,166	Foxp3	169,174	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin _ D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4 CD25 Foxp3 regulatory T cells .
24452947	0	CD25	38,42	Foxp3	44,49	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24557710	0	CD25	132,136	Foxp3	137,142	CD25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Narrowband ultraviolet B phototherapy ameliorates acute_graft-versus-host_disease by a mechanism involving in vivo expansion of CD4 + CD25 + Foxp3 + regulatory T cells .
24617045	0	CD25	23,27	Foxp3	29,34	CD25	Foxp3	3559	50943	Gene	Gene	Role|nmod|START_ENTITY +|nsubj|Role +|dobj|cells cells|amod|END_ENTITY	Role of regulatory CD4 + CD25 + Foxp3 T cells in bronchial asthma in Egyptian children .
24716598	0	CD25	65,69	Foxp3	56,61	CD25	Foxp3	3559	50943	Gene	Gene	CD4|amod|START_ENTITY CD4|amod|END_ENTITY	Decreased expression of Runx1 and lowered proportion of Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells in systemic_sclerosis .
24813240	0	CD25	95,99	Foxp3	104,109	CD25	Foxp3	3559	50943	Gene	Gene	capacity|nmod|START_ENTITY facilitates|dobj|capacity Interleukin-17|dep|facilitates Interleukin-17|dep|END_ENTITY	Interleukin-17 facilitates the immune suppressor capacity of high-grade glioma-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells via releasing transforming_growth_factor_beta .
24931519	0	CD25	44,48	Foxp3	19,24	CD25	Foxp3	3559	50943	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
25030097	0	CD25	55,59	Foxp3	62,67	CD25	Foxp3	3559	50943	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Comment on Adamzik et al. : An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory_distress_syndrome is associated with increased 30-day mortality .
25054604	0	CD25	127,131	Foxp3	134,139	CD25	Foxp3	3559	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Patients with systemic_lupus_erythematosus and secondary_antiphospholipid_syndrome have decreased numbers of circulating CD4 CD25 Foxp3 Treg and CD3 CD19 B cells .
25523632	0	CD25	31,35	Foxp3	23,28	CD25	Foxp3	3559	50943	Gene	Gene	START_ENTITY|nsubj|Extension Extension|nmod|END_ENTITY	Extension of the CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- CD25 -LRB- - / low -RRB- regulatory T-cell subpopulation in type_1_diabetes_mellitus .
25560411	0	CD25	55,59	Foxp3	104,109	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
25595257	0	CD25	95,99	Foxp3	100,105	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4 + CD25 + Foxp3 + T cells -LRB- Tregs -RRB- in a mouse study for active DNA Ab42 immunotherapy .
26063731	0	CD25	52,56	Foxp3	28,33	CD25	Foxp3	3559	50943	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells expression|amod|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	CD25	52,56	Foxp3	57,62	CD25	Foxp3	3559	50943	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26273136	0	CD25	35,39	Foxp3	42,47	CD25	Foxp3	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|Cells Cells|nsubj|END_ENTITY	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
26438270	0	CD25	99,103	Foxp3	106,111	CD25	Foxp3	3669	50943	Gene	Gene	correlates|nmod|START_ENTITY correlates|dobj|generation generation|amod|END_ENTITY	Up-regulated S100_calcium_binding_protein_A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
26862849	0	CD25	17,21	Foxp3	22,27	CD25	Foxp3	3559	50943	Gene	Gene	Frequency|nmod|START_ENTITY +|nsubj|Frequency +|dobj|cells cells|amod|END_ENTITY	Frequency of CD4 + CD25 + Foxp3 + cells in peripheral blood in relation to urinary bladder_cancer malignancy indicators before and after surgical removal .
11812990	0	CD25	15,19	GITR	56,60	CD25	GITR	16184(Tax:10090)	21936(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|dep|cells cells|nmod|END_ENTITY	Stimulation of CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells through GITR breaks immunological self-tolerance .
17391121	0	CD25	53,57	GITR	0,4	CD25	GITR	16184(Tax:10090)	21936(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY allograft|nmod|cells allograft|nsubj|blocks blocks|amod|END_ENTITY	GITR ligation blocks allograft protection by induced CD25 + CD4 + regulatory T cells without enhancing effector T-cell function .
20139172	0	CD25	84,88	GITR	0,4	CD25	GITR	16184(Tax:10090)	21936(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhances|dobj|proliferation enhances|nsubj|engagement engagement|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
21052566	0	CD25	115,119	GITR	46,50	CD25	GITR	3669	8784	Gene	Gene	subset|compound|START_ENTITY expansion|nmod|subset Glucocorticoid_induced_TNFR-related_protein|dep|expansion Glucocorticoid_induced_TNFR-related_protein|appos|END_ENTITY	-LSB- Glucocorticoid_induced_TNFR-related_protein -LRB- GITR -RRB- as marker of human regulatory T cells : expansion of the GITR -LRB- + -RRB- CD25 cell subset in patients with systemic_lupus_erythematosus -RSB- .
21557210	0	CD25	7,11	GITR	17,21	CD25	GITR	3559	8784	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
25256257	0	CD25	31,35	GITR	24,28	CD25	GITR	3559	8784	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Expansion of regulatory GITR + CD25 Low / - CD4 + T cells in systemic_lupus_erythematosus patients .
19171501	0	CD25	134,138	GM-CSF	86,92	CD25	GM-CSF	16184(Tax:10090)	12981(Tax:10090)	Gene	Gene	function|compound|START_ENTITY type|nmod|function type|nsubj|Modulation Modulation|nmod|cells cells|acl|using using|dobj|delays delays|appos|END_ENTITY	Modulation of dendritic cells using granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- delays type 1 diabetes by enhancing CD4 + CD25 + regulatory T cell function .
25967708	0	CD25	25,29	HIF-1a	54,60	CD25	HIF-1a	3559	3091	Gene	Gene	Treg|compound|START_ENTITY Relationship|nmod|Treg Relationship|nmod|END_ENTITY	Relationship between CD4 + CD25 + Treg and expression of HIF-1a and Ki-67 in NSCLC patients .
24931519	0	CD25	44,48	HIF1a	10,15	CD25	HIF1a	3559	3091	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
26452441	0	CD25	63,67	Heat_Shock_Protein_60	29,50	CD25	Heat Shock Protein 60	16184(Tax:10090)	15510(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intranasal Immunization with Heat_Shock_Protein_60 Induces CD4 + CD25 + GARP + and Type-1 Regulatory T Cells and Inhibits Early Atherosclerosis .
15184501	0	CD25	4,8	ICOS	42,46	CD25	ICOS	3559	29851	Gene	Gene	cells|compound|START_ENTITY cells|amod|dependent dependent|nmod|END_ENTITY	CD4 + CD25 + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic_lesion .
19448155	0	CD25	21,25	ICOS	32,36	CD25	ICOS	16184(Tax:10090)	54167(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
22815292	0	CD25	49,53	ICOS	0,4	CD25	ICOS	16184(Tax:10090)	54167(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY generation|nmod|Foxp3 mediates|dobj|generation mediates|nsubj|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
15611472	0	CD25	26,30	IFN-gamma	50,59	CD25	IFN-gamma	16184(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|mice mice|amod|END_ENTITY	Impaired up-regulation of CD25 on CD4 + T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart_failure .
15743488	0	CD25	14,18	IFN-gamma	150,159	CD25	IFN-gamma	16184(Tax:10090)	15978(Tax:10090)	Gene	Gene	functioning|compound|START_ENTITY functioning|dep|factor factor|nmod|pathogenesis pathogenesis|acl|counter-regulated counter-regulated|nmod|END_ENTITY	Defective CD4 + CD25 + regulatory T cell functioning in collagen-induced_arthritis : an important factor in pathogenesis , counter-regulated by endogenous IFN-gamma .
15935883	0	CD25	106,110	IFN-gamma	40,49	CD25	IFN-gamma	3559	3458	Gene	Gene	cells|compound|START_ENTITY effect|nmod|cells regulating|dobj|effect controls|advcl|regulating controls|dobj|production production|amod|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
16177085	0	CD25	53,57	IFN-gamma	0,9	CD25	IFN-gamma	16184(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generation/activation|nmod|cells controls|dobj|generation/activation controls|nsubj|END_ENTITY	IFN-gamma controls the generation/activation of CD4 + CD25 + regulatory T cells in antitumor immune response .
16906223	0	CD25	63,67	IFN-gamma	8,17	CD25	IFN-gamma	16184(Tax:10090)	15978(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
17851131	0	CD25	29,33	IFN-gamma	85,94	CD25	IFN-gamma	3669	3458	Gene	Gene	frequency|nmod|START_ENTITY inhibit|nsubj|frequency inhibit|dobj|induction induction|nmod|cells cells|amod|END_ENTITY	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
18298587	0	CD25	62,66	IFN-gamma	67,76	CD25	IFN-gamma	3669	3458	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Observational support for an immunoregulatory role of CD3 + CD4 + CD25 + IFN-gamma + blood lymphocytes in kidney transplant recipients with good long-term graft outcome .
18388182	0	CD25	5,9	IFN-gamma	73,82	CD25	IFN-gamma	3669	3458	Gene	Gene	cells|compound|START_ENTITY inhibit|nsubj|cells inhibit|advcl|produce produce|dobj|END_ENTITY	CD4 + CD25 + Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6 .
19654865	0	CD25	63,67	IFN-gamma	41,50	CD25	IFN-gamma	3559	3458	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|levels levels|nmod|CD4 CD4|compound|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
19853929	0	CD25	31,35	IFN-gamma	86,95	CD25	IFN-gamma	3559	3458	Gene	Gene	Conversion|nmod|START_ENTITY T|nsubj|Conversion T|nmod|CD25 CD25|nmod|cells cells|dep|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19853929	0	CD25	56,60	IFN-gamma	86,95	CD25	IFN-gamma	3559	3458	Gene	Gene	START_ENTITY|nmod|cells cells|dep|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
25924431	0	CD25	45,49	IFNAR	20,25	CD25	IFNAR	3669	3454	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Effects of altered IFNAR expression on CD4 + CD25 + treg cell dysfunction in patients with systemic_lupus_erythematosus -RSB- .
18477692	0	CD25	70,74	IL-1	25,29	CD25	IL-1	16184(Tax:10090)	111343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion/differentiation|nmod|+ END_ENTITY|nmod|expansion/differentiation	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
11207250	0	CD25	0,4	IL-10	94,99	CD25	IL-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY +|nsubj|CD4 +|ccomp|regulate regulate|nmod|production production|nmod|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11809742	0	CD25	12,16	IL-10	114,119	CD25	IL-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Natural CD4 CD25 -LRB- + -RRB- regulatory T cells control the burst of superantigen-induced cytokine production : the role of IL-10 .
12609834	0	CD25	43,47	IL-10	0,5	CD25	IL-10	3559	3586	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	IL-10 and TGF-beta induce alloreactive CD4 + CD25 - T cells to acquire regulatory cell function .
12928371	0	CD25	45,49	IL-10	27,32	CD25	IL-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY induces|dobj|populations induces|nsubj|overexpression overexpression|nmod|END_ENTITY	Systemic overexpression of IL-10 induces CD4 + CD25 + cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion .
14519757	0	CD25	97,101	IL-10	52,57	CD25	IL-10	3559	3586	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ END_ENTITY|nmod|generation	The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4 + CD25 + and CD8 + regulatory T cell subsets .
14734610	0	CD25	85,89	IL-10	0,5	CD25	IL-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY involved|nmod|cells involved|nsubjpass|END_ENTITY	IL-10 is involved in the suppression of experimental_autoimmune_encephalomyelitis by CD25 + CD4 + regulatory T cells .
16622000	0	CD25	61,65	IL-10	16,21	CD25	IL-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ independent|nmod|cells independent|nsubj|cells cells|compound|END_ENTITY	Antigen-induced IL-10 + regulatory T cells are independent of CD25 + regulatory cells for their growth , differentiation , and function .
17389235	0	CD25	64,68	IL-10	24,29	CD25	IL-10	3559	3586	Gene	Gene	+|compound|START_ENTITY distinct|nmod|+ cells|amod|distinct accumulation|dep|cells accumulation|nmod|mRNA mRNA|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17990114	0	CD25	4,8	IL-10	82,87	CD25	IL-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|nmod|intestinal_inflammation intestinal_inflammation|nmod|mice mice|compound|END_ENTITY	CD4 + CD25 + regulatory T cells have divergent effects on intestinal_inflammation in IL-10 gene-deficient mice .
19849943	0	CD25	16,20	IL-10	42,47	CD25	IL-10	3559	3586	Gene	Gene	Changes|nmod|START_ENTITY +|nsubj|Changes +|dobj|cells cells|appos|levels levels|amod|END_ENTITY	-LSB- Changes of CD4 + CD25 + regulatory T cells , IL-10 and TGF-beta1 levels in peripheral blood in children with asthma -RSB- .
20977501	0	CD25	58,62	IL-10	33,38	CD25	IL-10	3559	3586	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|production production|compound|END_ENTITY	Neonatal BCG vaccination induces IL-10 production by CD4 + CD25 + T cells .
21533081	0	CD25	45,49	IL-10	28,33	CD25	IL-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	TLR2-dependent induction of IL-10 and Foxp3 + CD25 + CD4 + regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo .
22708352	0	CD25	16,20	IL-10	105,110	CD25	IL-10	281861(Tax:9913)	281246(Tax:9913)	Gene	Gene	presence|nmod|START_ENTITY correlated|nsubjpass|presence correlated|nmod|production production|nmod|END_ENTITY	The presence of CD25 on bovine WC1 + gammadelta T cells is positively correlated with their production of IL-10 and TGF-beta , but not IFN-gamma .
24452947	0	CD25	38,42	IL-10	146,151	CD25	IL-10	3559	3586	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells contributes|nsubj|induction contributes|nmod|regulation regulation|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
25316133	0	CD25	41,45	IL-10	130,135	CD25	IL-10	3559	3586	Gene	Gene	FoxP3|compound|START_ENTITY levels|nmod|FoxP3 changes|nmod|levels changes|dep|role role|nmod|END_ENTITY	Allergy-related changes in levels of CD8 + CD25 + FoxP3 -LRB- bright -RRB- Treg cells and FoxP3 mRNA expression in peripheral blood : the role of IL-10 or TGF-beta .
26829554	0	CD25	37,41	IL-10	13,18	CD25	IL-10	3559	3586	Gene	Gene	Correlates|compound|START_ENTITY Induction|nmod|Correlates Induction|nmod|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
26928119	0	CD25	111,115	IL-10	79,84	CD25	IL-10	3559	3586	Gene	Gene	production|acl:relcl|START_ENTITY production|compound|END_ENTITY	NAD -LRB- + -RRB- regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells independent .
8069928	0	CD25	220,224	IL-10	33,38	CD25	IL-10	3559	3586	Gene	Gene	upregulation|nmod|START_ENTITY different|nmod|upregulation mechanism|acl:relcl|different enhance|nmod|mechanism IL-2|xcomp|enhance expression|amod|IL-2 synergizes|nmod|expression interplay|dep|synergizes interplay|nmod|interleukin-10 interleukin-10|appos|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
9636688	0	CD25	103,107	IL-10	69,74	CD25	IL-10	3559	3586	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2 , IL-4 , and IL-10 secretion and expression of CD25 , CD40L , and CD69 .
18493981	0	CD25	40,44	IL-15	0,5	CD25	IL-15	3559	3600	Gene	Gene	cells|amod|START_ENTITY inducer|nmod|cells expressing|nsubj|inducer acts|advcl|expressing acts|nsubj|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
23028916	0	CD25	100,104	IL-15	0,5	CD25	IL-15	16184(Tax:10090)	16168(Tax:10090)	Gene	Gene	T|compound|START_ENTITY function|nmod|T inhibiting|dobj|function vitro|advcl|inhibiting cells|amod|vitro expansion|nmod|cells augments|dobj|expansion augments|nsubj|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23776439	0	CD25	25,29	IL-17	111,116	CD25	IL-17	3559	3605	Gene	Gene	FoxP3|amod|START_ENTITY levels|nmod|FoxP3 T|nsubj|levels T|ccomp|contribute contribute|nmod|secretion secretion|nmod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
25790134	0	CD25	50,54	IL-17A	25,31	CD25	IL-17A	16184(Tax:10090)	16171(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Production|nmod|Foxp3 Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
15153463	0	CD25	77,81	IL-2	14,18	CD25	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	function|compound|START_ENTITY activation|nmod|function required|nmod|activation required|nsubjpass|END_ENTITY	Cutting edge : IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function .
15470042	0	CD25	11,15	IL-2	116,120	CD25	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY fail|nsubj|cells fail|xcomp|undergo undergo|nmod|region region|nmod|gene gene|compound|END_ENTITY	Murine CD4 + CD25 + regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene .
15770696	0	CD25	83,87	IL-2	57,61	CD25	IL-2	3559	3558	Gene	Gene	cells|compound|START_ENTITY help|nmod|cells cells|dep|help cells|amod|END_ENTITY	Activated CD1d-restricted natural killer T cells secrete IL-2 : innate help for CD4 + CD25 + regulatory T cells ?
16304057	0	CD25	35,39	IL-2	0,4	CD25	IL-2	3559	3558	Gene	Gene	Foxp3|compound|START_ENTITY increases|dobj|Foxp3 increases|nsubj|administration administration|compound|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
16645171	0	CD25	45,49	IL-2	0,4	CD25	IL-2	3559	3558	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16887978	0	CD25	110,114	IL-2	69,73	CD25	IL-2	3559	3558	Gene	Gene	cells|compound|START_ENTITY limits|nmod|cells limits|dobj|production production|compound|END_ENTITY	Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4 + CD25 + regulatory T cells .
16917540	0	CD25	55,59	IL-2	14,18	CD25	IL-2	3559	3558	Gene	Gene	Tregs|compound|START_ENTITY expansion|nmod|Tregs expansion|compound|END_ENTITY	PTEN inhibits IL-2 receptor-mediated expansion of CD4 + CD25 + Tregs .
17015695	0	CD25	88,92	IL-2	26,30	CD25	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	T|compound|START_ENTITY production|nmod|T controlling|dobj|production determinant|acl|controlling determinant|nsubj|availability availability|nmod|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17277105	0	CD25	67,71	IL-2	0,4	CD25	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells convert|dobj|CD25 essential|xcomp|convert essential|nsubj|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17545278	0	CD25	30,34	IL-2	64,68	CD25	IL-2	3559	3558	Gene	Gene	function|compound|START_ENTITY maintenance|nmod|function maintenance|dep|potency potency|compound|END_ENTITY	The maintenance of human CD4 + CD25 + regulatory T cell function : IL-2 , IL-4 , IL-7 and IL-15 preserve optimal suppressive potency in vitro .
20081380	0	CD25	64,68	IL-2	24,28	CD25	IL-2	3559	3558	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells END_ENTITY|nmod|expansion	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20574434	0	CD25	51,55	IL-2	77,81	CD25	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY D3|nmod|cells regulation|nmod|D3 enabled|nsubjpass|regulation enabled|nmod|END_ENTITY	Gene regulation by 1,25-dihydroxyvitamin _ D3 in CD4 + CD25 + cells is enabled by IL-2 .
22984435	0	CD25	28,32	IL-2	104,108	CD25	IL-2	3559	3558	Gene	Gene	function|compound|START_ENTITY function|dep|vitro vitro|nmod|delivery delivery|nmod|END_ENTITY	Dendritic cells control CD4 + CD25 + Treg cell suppressor function in vitro through juxtacrine delivery of IL-2 .
27049955	0	CD25	82,86	IL-2	47,51	CD25	IL-2	3559	3558	Gene	Gene	Suppression|compound|START_ENTITY Production|dep|Suppression Production|nsubj|Signaling Signaling|nmod|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
8069928	0	CD25	220,224	IL-2	59,63	CD25	IL-2	3559	3558	Gene	Gene	upregulation|nmod|START_ENTITY different|nmod|upregulation mechanism|acl:relcl|different enhance|nmod|mechanism IL-2|xcomp|enhance expression|amod|IL-2 synergizes|nmod|expression interplay|dep|synergizes interplay|nmod|interleukin-10 interleukin-10|appos|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
18052963	0	CD25	21,25	IL-21	0,5	CD25	IL-21	16184(Tax:10090)	60505(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	IL-21 modulates CD4 + CD25 + regulatory T-cell homeostasis in experimental_autoimmune_encephalomyelitis .
21400499	0	CD25	36,40	IL-22	0,5	CD25	IL-22	16184(Tax:10090)	50929(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produced|nmod|cells produced|nsubjpass|END_ENTITY	IL-22 is produced by yC-independent CD25 + CCR6 + innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality .
24376757	0	CD25	81,85	IL-2R	57,62	CD25	IL-2R	3559	3560	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4 + CD25 -LRB- hi -RRB- T cells of type 1 diabetic and multiple_sclerosis patients .
8268974	0	CD25	29,33	IL-2R	22,27	CD25	IL-2R	3559	3559	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	Relationship of IL-2 , IL-2R -LRB- CD25 + -RRB- , soluble IL-2R and IL-4 with disease activity in SLE patients .
20849903	0	CD25	22,26	IL-2RA	15,21	CD25	IL-2RA	3559	3559	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association of IL-2RA / CD25 with type 1 diabetes in the Belgian population .
1398765	0	CD25	14,18	IL-2R_alpha	20,31	CD25	IL-2R alpha	3559	3559	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Inhibition of CD25 -LRB- IL-2R_alpha -RRB- expression and T-cell proliferation by polyclonal anti-thymocyte globulins .
12218142	0	CD25	171,175	IL-4	10,14	CD25	IL-4	16184(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY control|nmod|cells subject|nmod|control subject|nsubj|response response|compound|END_ENTITY	The early IL-4 response to Leishmania_major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 + CD25 + T cells .
16237107	0	CD25	99,103	IL-4	4,8	CD25	IL-4	16184(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induce|dobj|cells alpha-chain-binding|ccomp|induce alpha-chain-binding|nsubj|receptor receptor|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16237107	0	CD25	99,103	IL-4	49,53	CD25	IL-4	16184(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induce|dobj|cells induce|nsubj|cytokines cytokines|appos|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
22310911	0	CD25	48,52	IL-5	0,4	CD25	IL-5	3559	3567	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells promotes|dobj|induction promotes|nsubj|END_ENTITY	IL-5 promotes induction of antigen-specific CD4 + CD25 + T regulatory cells that suppress autoimmunity .
15935883	0	CD25	106,110	IL-6	0,4	CD25	IL-6	3559	3569	Gene	Gene	cells|compound|START_ENTITY effect|nmod|cells regulating|dobj|effect controls|advcl|regulating controls|nsubj|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
17182564	0	CD25	68,72	IL-6	0,4	CD25	IL-6	16184(Tax:10090)	16193(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY functions|nsubj|cell inhibits|xcomp|functions inhibits|nsubj|END_ENTITY	IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4 + CD25 + T cell regulatory functions .
15922716	0	CD25	48,52	IL-7	11,15	CD25	IL-7	3559	3574	Gene	Gene	induction|nmod|START_ENTITY Effects|dep|induction Effects|nmod|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
20693259	0	CD25	11,15	IL-7	45,49	CD25	IL-7	3559	3574	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|lack lack|dobj|receptor receptor|compound|END_ENTITY	Numbers of CD25 + Foxp3 + T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients .
18566388	0	CD25	29,33	IL-7R	15,20	CD25	IL-7R	16184(Tax:10090)	16197(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
16698664	0	CD25	16,20	IL2R	10,14	CD25	IL2R	3559	3559	Gene	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	A reduced IL2R -LRB- CD25 -RRB- expression level in first and second degree female relatives of autoimmune_thyroid_disease patients .
15217455	0	CD25	68,72	Interleukin-2	0,13	CD25	Interleukin-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY depletion|nmod|cells caused|nmod|depletion activity|acl|caused blocks|dobj|activity blocks|nsubj|END_ENTITY	Interleukin-2 blocks the antitumour activity caused by depletion of CD25 cells in a murine renal_adenocarcinoma model .
15307180	0	CD25	35,39	Interleukin-2	0,13	CD25	Interleukin-2	3559	3558	Gene	Gene	function|compound|START_ENTITY essential|nmod|function essential|nsubj|END_ENTITY	Interleukin-2 is essential for CD4 + CD25 + regulatory T cell function .
25485946	0	CD25	96,100	Interleukin-2	68,81	CD25	Interleukin-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY +|nmod|Expression +|dobj|Reactivity Reactivity|nmod|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
16380489	0	CD25	44,48	Interleukin-7	0,13	CD25	Interleukin-7	16184(Tax:10090)	16196(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY factor|nmod|T-cells factor|nsubj|END_ENTITY	Interleukin-7 is a survival factor for CD4 + CD25 + T-cells and is expressed by diabetes-suppressive_dendritic_cells .
25485946	0	CD25	96,100	Interleukin-7	0,13	CD25	Interleukin-7	16184(Tax:10090)	16196(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY +|nmod|Expression +|nsubj|CD4 CD4|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
12193715	0	CD25	25,29	L-selectin	95,105	CD25	L-selectin	16184(Tax:10090)	20343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY subpopulation|nmod|+ splenocytes|nsubj|subpopulation splenocytes|ccomp|expresses expresses|dobj|levels levels|amod|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
17182566	0	CD25	0,4	L-selectin	47,57	CD25	L-selectin	16184(Tax:10090)	20343(Tax:10090)	Gene	Gene	migration|compound|START_ENTITY requires|nsubj|migration requires|dobj|expression expression|amod|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
17182566	0	CD25	0,4	L-selectin	70,80	CD25	L-selectin	16184(Tax:10090)	20343(Tax:10090)	Gene	Gene	migration|compound|START_ENTITY requires|nsubj|migration requires|parataxis|balances balances|nsubj|regulation regulation|amod|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
15600300	0	CD25	96,100	NY-ESO-1	35,43	CD25	NY-ESO-1	3559	246100	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|nmod|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
17641007	0	CD25	94,98	OX40	14,18	CD25	OX40	3559	7293	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|nsubj|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
24797972	0	CD25	69,73	OX40	19,23	CD25	OX40	3559	7293	Gene	Gene	cells|amod|START_ENTITY molecules|nmod|cells molecules|nsubj|expression expression|nmod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
19229109	0	CD25	31,35	PD-L1	0,5	CD25	PD-L1	3559	29126	Gene	Gene	Tregs|compound|START_ENTITY regulates|dobj|Tregs regulates|nsubj|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
26166019	0	CD25	40,44	PD-L1	27,32	CD25	PD-L1	3559	29126	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26266813	0	CD25	27,31	PD-L1	14,19	CD25	PD-L1	3559	29126	Gene	Gene	Foxp3|compound|START_ENTITY END_ENTITY|nmod|Foxp3	Expression of PD-L1 on CD4 + CD25 + Foxp3 + Regulatory T Cells of Patients with Chronic_HBV_Infection and Its Correlation with Clinical Parameters .
15728475	0	CD25	47,51	Platelet_factor_4	0,17	CD25	Platelet factor 4	3559	5196	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD25	77,81	Platelet_factor_4	0,17	CD25	Platelet factor 4	3559	5196	Gene	Gene	+|nmod|START_ENTITY END_ENTITY|nsubj|+	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
26438270	0	CD25	99,103	S100_calcium_binding_protein_A8	13,44	CD25	S100 calcium binding protein A8	3669	6279	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Up-regulated S100_calcium_binding_protein_A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
17621372	0	CD25	34,38	SOCS3	10,15	CD25	SOCS3	3559	9021	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
16540526	0	CD25	92,96	STAT-3	62,68	CD25	STAT-3	3559	6774	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4 + CD25 - and CD25high regulatory T cells .
14699080	0	CD25	29,33	STAT1	72,77	CD25	STAT1	16184(Tax:10090)	20846(Tax:10090)	Gene	Gene	+|compound|START_ENTITY development|nmod|+ cells|dep|development cells|nmod|absence absence|nmod|END_ENTITY	Impaired development of CD4 + CD25 + regulatory T cells in the absence of STAT1 : increased susceptibility to autoimmune_disease .
18025205	0	CD25	21,25	STAT3	8,13	CD25	STAT3	16184(Tax:10090)	20848(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
12612581	0	CD25	37,41	Scurfin	22,29	CD25	Scurfin	16184(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	An essential role for Scurfin in CD4 + CD25 + T regulatory cells .
21314640	0	CD25	26,30	TGF-b	106,111	CD25	TGF-b	3669	7040	Gene	Gene	cells|nummod|START_ENTITY effect|nmod|cells requires|nsubj|effect requires|dobj|contact contact|nmod|production production|amod|END_ENTITY	The suppressive effect of CD25 + Treg cells on Th1 differentiation requires cell-cell contact partially via TGF-b production .
24454972	0	CD25	34,38	TGF-b	12,17	CD25	TGF-b	3559	7040	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
26067079	0	CD25	4,8	TGF-b	132,137	CD25	TGF-b	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	Natural|compound|START_ENTITY Killer|nsubj|Natural Killer|dobj|Hepatocytotoxicity Hepatocytotoxicity|nmod|Transgenic_Mice Transgenic_Mice|nmod|END_ENTITY	CD4 + CD25 + Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis_B_Virus Transgenic_Mice via Membrane-Bound TGF-b and OX40 .
22749982	0	CD25	66,70	TGF-b1	37,43	CD25	TGF-b1	3559	7040	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|CD152 CD152|appos|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
24904415	0	CD25	4,8	TGF-b1	119,125	CD25	TGF-b1	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY inhibit|nsubj|Tregs inhibit|dobj|recruitment recruitment|nmod|suppression suppression|nmod|production production|nmod|lung lung|amod|exposed exposed|amod|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
11390478	0	CD25	59,63	TGF-beta	11,19	CD25	TGF-beta	3559	7040	Gene	Gene	generation|nmod|START_ENTITY END_ENTITY|nmod|generation	A role for TGF-beta in the generation and expansion of CD4 + CD25 + regulatory T cells from human peripheral blood .
12651220	0	CD25	34,38	TGF-beta	0,8	CD25	TGF-beta	3559	7040	Gene	Gene	immunosuppression|compound|START_ENTITY link|nmod|immunosuppression END_ENTITY|dep|link	TGF-beta : the missing link in CD4 + CD25 + regulatory T cell-mediated immunosuppression .
14676299	0	CD25	29,33	TGF-beta	84,92	CD25	TGF-beta	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|dep|cells cells|nmod|CD25 CD25|acl|+ +|nmod|induction induction|amod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	CD25	56,60	TGF-beta	84,92	CD25	TGF-beta	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|acl|+ +|nmod|induction induction|amod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15070759	0	CD25	61,65	TGF-beta	0,8	CD25	TGF-beta	3559	7040	Gene	Gene	expansion|nmod|START_ENTITY +|nsubj|expansion regulates|advcl|+ regulates|nsubj|END_ENTITY	TGF-beta regulates in vivo expansion of Foxp3-expressing CD4 + CD25 + regulatory T cells responsible for protection against diabetes .
15367216	0	CD25	55,59	TGF-beta	0,8	CD25	TGF-beta	3559	7040	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
16612596	0	CD25	20,24	TGF-beta	94,102	CD25	TGF-beta	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	involves|nsubj|START_ENTITY involves|dobj|END_ENTITY	Tumor-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cell suppression of dendritic cell function involves TGF-beta and IL-10 .
17277105	0	CD25	52,56	TGF-beta	22,30	CD25	TGF-beta	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	convert|dobj|START_ENTITY essential|xcomp|convert essential|nmod|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17277105	0	CD25	67,71	TGF-beta	22,30	CD25	TGF-beta	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells convert|dobj|CD25 essential|xcomp|convert essential|nmod|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17353088	0	CD25	45,49	TGF-beta	128,136	CD25	TGF-beta	3559	7040	Gene	Gene	START_ENTITY|acl:relcl|T T|advcl|secreting secreting|dobj|END_ENTITY	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17353088	0	CD25	94,98	TGF-beta	128,136	CD25	TGF-beta	3559	7040	Gene	Gene	cells|nmod|START_ENTITY T|nsubj|cells T|advcl|secreting secreting|dobj|END_ENTITY	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17641007	0	CD25	94,98	TGF-beta	28,36	CD25	TGF-beta	3559	7040	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|conversion conversion|amod|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17688698	0	CD25	131,135	TGF-beta	11,19	CD25	TGF-beta	3559	7040	Gene	Gene	induction|nmod|START_ENTITY key|nmod|induction key|nsubj|activation activation|amod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
20684851	0	CD25	49,53	TGF-beta	15,23	CD25	TGF-beta	3559	7040	Gene	Gene	T|nsubj|START_ENTITY T|nmod|converts converts|amod|END_ENTITY	In vitro human TGF-beta treatment converts CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells into induced T regulatory like cells .
15016653	0	CD25	90,94	TGF-beta1	140,149	CD25	TGF-beta1	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells inflammation|nmod|suppression inflammation|nmod|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
16180248	0	CD25	29,33	TGF-beta1	0,9	CD25	TGF-beta1	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	TGF-beta1 production by CD4 + CD25 + regulatory T cells is not essential for suppression of intestinal_inflammation .
14707053	0	CD25	59,63	TGF-beta_1	0,10	CD25	TGF-beta 1	3559	7040	Gene	Gene	activity|compound|START_ENTITY mechanism|nmod|activity role|nmod|mechanism plays|dobj|role plays|nsubj|END_ENTITY	TGF-beta_1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice .
17911604	0	CD25	59,63	TGF-beta_1	85,95	CD25	TGF-beta 1	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induces|dobj|+ induces|parataxis|adaptive adaptive|nsubj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
25148371	0	CD25	29,33	TL1A	0,4	CD25	TL1A	3559	9966	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	TL1A increases expression of CD25 , LFA-1 , CD134 and CD154 , and induces IL-22 and GM-CSF production from effector CD4 T-cells .
25790134	0	CD25	50,54	TLR-2	0,5	CD25	TLR-2	16184(Tax:10090)	24088(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Production|nmod|Foxp3 Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
16767222	0	CD25	36,40	TLR2	80,84	CD25	TLR2	3559	7097	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Heat_shock protein 60 enhances CD4 + CD25 + regulatory T cell function via innate TLR2 signaling .
19882655	0	CD25	4,8	TLR2	90,94	CD25	TLR2	16184(Tax:10090)	24088(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY dependent|nsubj|Treg dependent|advmod|END_ENTITY	CD4 + CD25 + Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma_japonicum is TLR2 dependent .
16339542	0	CD25	122,126	TLR5	27,31	CD25	TLR5	3559	7100	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|nsubj|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
18053016	0	CD25	42,46	TNF-alpha	106,115	CD25	TNF-alpha	3559	7124	Gene	Gene	cells|compound|START_ENTITY insufficiency|nmod|cells subjected|nsubjpass|insufficiency subjected|nmod|modulation modulation|amod|END_ENTITY	The functional insufficiency of human CD4 + CD25 high T-regulatory cells in allergic_asthma is subjected to TNF-alpha modulation .
18178849	0	CD25	68,72	TNF-alpha	0,9	CD25	TNF-alpha	16184(Tax:10090)	21926(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY population|nmod|cells generates|dobj|population generates|nsubj|antagonism antagonism|amod|END_ENTITY	TNF-alpha antagonism generates a population of antigen-specific CD4 + CD25 + T cells that inhibit protective immunity in murine histoplasmosis .
18453563	0	CD25	86,90	TNFR2	28,33	CD25	TNFR2	16184(Tax:10090)	21938(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells defines|dobj|subset defines|nsubj|expression expression|nmod|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
15016653	0	CD25	90,94	Tgf-beta1	44,53	CD25	Tgf-beta1	16184(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells inflammation|nmod|suppression inflammation|nmod|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15240714	0	CD25	0,4	Th1	88,91	CD25	Th1	16184(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY contribute|nsubj|cells contribute|xcomp|Th2 Th2|advcl|suppressing suppressing|dobj|development development|amod|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
16998360	0	CD25	15,19	Th1	88,91	CD25	Th1	3559	51497	Gene	Gene	activity|compound|START_ENTITY depresses|nsubj|activity depresses|dobj|immunity immunity|amod|END_ENTITY	Increased CD4 + CD25 + T regulatory cell activity in trauma patients depresses protective Th1 immunity .
17563757	0	CD25	22,26	Th1	69,72	CD25	Th1	16184(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Downregulation|nmod|cells underlie|nsubj|Downregulation underlie|dobj|immunity immunity|amod|END_ENTITY	Downregulation of CD4 + CD25 + regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells .
20128236	0	CD25	4,8	Th1	62,65	CD25	Th1	16184(Tax:10090)	57314(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|prevent prevent|dobj|development development|nmod|response response|amod|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium_yoelii infection in susceptible BALB/c mice .
23734780	0	CD25	38,42	Th1	117,120	CD25	Th1	16184(Tax:10090)	57314(Tax:10090)	Gene	Gene	population|compound|START_ENTITY generate|dobj|population generate|nmod|process process|nmod|cells cells|amod|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
15240714	0	CD25	0,4	Th2	30,33	CD25	Th2	16184(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY contribute|nsubj|cells contribute|xcomp|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
23161469	0	CD25	36,40	Tim-3	91,96	CD25	Tim-3	3559	84868	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|nmod|pathway pathway|amod|/ /|amod|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
16632602	0	CD25	63,67	Toll-like_receptor_2	0,20	CD25	Toll-like receptor 2	16184(Tax:10090)	24088(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY functions|nmod|cells modulates|dobj|functions modulates|nsubj|signaling signaling|compound|END_ENTITY	Toll-like_receptor_2 signaling modulates the functions of CD4 + CD25 + regulatory T cells .
17296785	0	CD25	61,65	WASP	0,4	CD25	WASP	16184(Tax:10090)	7454	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	WASP regulates suppressor activity of human and murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- natural regulatory T cells .
18928784	0	CD25	69,73	WC1	25,28	CD25	WC1	281861(Tax:9913)	751809(Tax:9913)	Gene	Gene	Foxp3|compound|START_ENTITY T|nmod|Foxp3 T|nsubj|Subpopulations Subpopulations|nmod|gammadelta gammadelta|compound|END_ENTITY	Subpopulations of bovine WC1 -LRB- + -RRB- gammadelta T cells rather than CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells act as immune regulatory cells ex vivo .
22708352	0	CD25	16,20	WC1	31,34	CD25	WC1	281861(Tax:9913)	751809(Tax:9913)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	The presence of CD25 on bovine WC1 + gammadelta T cells is positively correlated with their production of IL-10 and TGF-beta , but not IFN-gamma .
21255222	0	CD25	34,38	aquaporin-4	14,25	CD25	aquaporin-4	16184(Tax:10090)	11829(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Novel role of aquaporin-4 in CD4 + CD25 + T regulatory cell development and severity of Parkinson 's _ disease .
16177056	0	CD25	128,132	aryl_hydrocarbon_receptor	32,57	CD25	aryl hydrocarbon receptor	16184(Tax:10090)	11622(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY population|nmod|cells generates|dobj|population generates|nsubj|activation activation|nmod|END_ENTITY	Cutting edge : activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4 + CD25 + cells with characteristics of regulatory T cells .
23039885	0	CD25	95,99	cytotoxic_T_lymphocyte_antigen_4	41,73	CD25	cytotoxic T lymphocyte antigen 4	3559	1493	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	FOXP3 , CBLB and ITCH gene expression and cytotoxic_T_lymphocyte_antigen_4 expression on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- T cells in multiple_sclerosis .
18282273	0	CD25	9,13	foxp3	14,19	CD25	foxp3	3559	50943	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|determine determine|nsubj|cell cell|amod|END_ENTITY	Does CD4 + CD25 + foxp3 + cell -LRB- Treg -RRB- and IL-10 profile determine susceptibility to immune reconstitution inflammatory_syndrome -LRB- IRIS -RRB- in HIV_disease ?
12810075	0	CD25	53,57	heme_oxygenase-1	28,44	CD25	heme oxygenase-1	3559	3162	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Differential expressions of heme_oxygenase-1 gene in CD25 - and CD25 + subsets of human CD4 + T cells .
20888597	0	CD25	36,40	iNOS	106,110	CD25	iNOS	16184(Tax:10090)	18126(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY saline|nmod|Foxp3 Effects|nmod|saline +|nsubj|Effects +|nmod|END_ENTITY	Effects of hypertonic saline on CD4 + CD25 + Foxp3 + regulatory T cells after hemorrhagic_shock in relation to iNOS and cytokines .
15649266	0	CD25	67,71	interferon-gamma	79,95	CD25	interferon-gamma	3559	3458	Gene	Gene	+|compound|START_ENTITY recruitment|nmod|+ induces|dobj|recruitment induces|parataxis|+ +|nsubj|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15298560	0	CD25	101,105	interleukin-10	107,121	CD25	interleukin-10	3559	3586	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Induction of T ` regulatory ' cells by standardized house dust mite immunotherapy : an increase in CD4 + CD25 + interleukin-10 + T cells expressing peripheral tissue trafficking markers .
18824533	0	CD25	108,112	interleukin-10	144,158	CD25	interleukin-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY role|nmod|Foxp3 +|nsubj|role +|xcomp|independent independent|advcl|END_ENTITY	Schistosoma_mansoni antigens modulate experimental allergic_asthma in a murine model : a major role for CD4 + CD25 + Foxp3 + T cells independent of interleukin-10 .
20528588	0	CD25	16,20	interleukin-10	53,67	CD25	interleukin-10	3559	3586	Gene	Gene	defect|nmod|START_ENTITY +|nsubj|defect +|advcl|inducing inducing|dobj|production production|amod|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
21982068	0	CD25	99,103	interleukin-10	18,32	CD25	interleukin-10	16184(Tax:10090)	16153(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY percentages|nmod|Foxp3 +|nsubj|percentages decreases|ccomp|+ decreases|nsubj|Neutralization Neutralization|nmod|factor-b factor-b|amod|END_ENTITY	Neutralization of interleukin-10 or transforming growth factor-b decreases the percentages of CD4 + CD25 + Foxp3 + regulatory T cells in septic mice , thereby leading to an improved survival .
8069928	0	CD25	220,224	interleukin-10	17,31	CD25	interleukin-10	3559	3586	Gene	Gene	upregulation|nmod|START_ENTITY different|nmod|upregulation mechanism|acl:relcl|different enhance|nmod|mechanism IL-2|xcomp|enhance expression|amod|IL-2 synergizes|nmod|expression interplay|dep|synergizes interplay|nmod|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
11182148	0	CD25	103,107	interleukin-2	155,168	CD25	interleukin-2	396814(Tax:9823)	396868(Tax:9823)	Gene	Gene	phenotype|compound|START_ENTITY phenotype|acl|generated generated|advcl|vitro vitro|nmod|END_ENTITY	Functional characterization of a swine CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- double positive lymphoblastoid T-cell line with a CD25 -LRB- + -RRB- / CD45RA -LRB- - -RRB- phenotype generated in vitro with interleukin-2 .
1462123	0	CD25	144,148	interleukin-2	42,55	CD25	interleukin-2	3559	3558	Gene	Gene	interleukin-2_receptor|dep|START_ENTITY _|xcomp|interleukin-2_receptor _|nsubj|Spontaneous Spontaneous|nmod|transcription transcription|nmod|END_ENTITY	Spontaneous in vivo gene transcription of interleukin-2 , interleukin-3 , interleukin-4 , interleukin-6 , _ interferon-gamma , _ interleukin-2_receptor -LRB- CD25 -RRB- and proto-oncogene_c-myc by rheumatoid synovial T lymphocytes .
15507389	0	CD25	124,128	interleukin-2	66,79	CD25	interleukin-2	3559	3558	Gene	Gene	expression|compound|START_ENTITY increases|nmod|expression induces|dobj|increases induces|nsubj|BAY_50-4798 BAY_50-4798|appos|analog analog|compound|END_ENTITY	BAY_50-4798 , a novel , high-affinity receptor-specific recombinant interleukin-2 analog , induces dose-dependent increases in CD25 expression and proliferation among unstimulated , human peripheral blood mononuclear cells in vitro .
1571333	0	CD25	6,10	interleukin-2	25,38	CD25	interleukin-2	3559	3558	Gene	Gene	levels|compound|START_ENTITY levels|nmod|therapy therapy|compound|END_ENTITY	Serum CD25 levels during interleukin-2 therapy : dose dependence and correlations with clinical toxicity and lymphocyte surface sCD25 expression .
16505437	0	CD25	24,28	interleukin-2	84,97	CD25	interleukin-2	3559	3558	Gene	Gene	Characterization|nmod|START_ENTITY +|nsubj|Characterization +|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	Characterization of CD4 + CD25 + regulatory T cells in patients treated with high-dose interleukin-2 for metastatic_melanoma or renal_cell_carcinoma .
1667947	0	CD25	87,91	interleukin-2	72,85	CD25	interleukin-2	3559	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Evaluation of lymphocyte activation by flow cytometric determination of interleukin-2 -LRB- CD25 -RRB- receptor .
22851544	0	CD25	97,101	interleukin-2	22,35	CD25	interleukin-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 expands|ccomp|+ therapy|parataxis|expands therapy|nmod|END_ENTITY	Cytokine therapy with interleukin-2 / anti-interleukin-2 monoclonal antibody complexes expands CD4 + CD25 + Foxp3 + regulatory T cells and attenuates development and progression of atherosclerosis .
2896111	0	CD25	203,207	interleukin-2	178,191	CD25	interleukin-2	3559	3558	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Cyclosporin_A does not inhibit the PHA-stimulated increase in intracellular Ca2 + concentration but inhibits the increase in E-rosette receptor -LRB- CD2 -RRB- expression and appearance of interleukin-2 receptors -LRB- CD25 -RRB- .
3128947	0	CD25	54,58	interleukin-2	18,31	CD25	interleukin-2	3559	3558	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of the interleukin-2 receptor -LRB- Tac_antigen / CD25 -RRB- in hematologic_neoplasms .
7570988	0	CD25	55,59	interleukin-2	31,44	CD25	interleukin-2	3559	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Prolonged action of a chimeric interleukin-2 receptor -LRB- CD25 -RRB- monoclonal antibody used in cadaveric renal transplantation .
7619228	0	CD25	12,16	interleukin-2	93,106	CD25	interleukin-2	3559	3558	Gene	Gene	+|compound|START_ENTITY down-regulated|nmod|+ down-regulated|nmod|receptor receptor|compound|END_ENTITY	In vivo CD3 + CD25 + lymphocyte subpopulation is down-regulated without increased serum-soluble interleukin-2 receptor -LRB- sIL-2R -RRB- by gonadotropin releasing hormone agonist -LRB- GnRH-a -RRB- .
8050452	0	CD25	120,124	interleukin-2	96,109	CD25	interleukin-2	3559	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Dietary supplementation with very long-chain n-3 fatty_acids in man decreases expression of the interleukin-2 receptor -LRB- CD25 -RRB- on mitogen-stimulated lymphocytes from patients with inflammatory skin_diseases .
9111583	0	CD25	38,42	interleukin-2	14,27	CD25	interleukin-2	3559	3558	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of interleukin-2 receptor -LRB- CD25 -RRB- expression induced on T cells from children with acute_lymphoblastic_leukemia .
9670041	0	CD25	4,8	interleukin_2	96,109	CD25	interleukin 2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|suppress suppress|advcl|inhibiting inhibiting|dobj|production production|amod|END_ENTITY	CD4 + CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin_2 production .
16051465	0	CD25	28,32	interleukin_4	11,24	CD25	interleukin 4	16184(Tax:10090)	16189(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Effects of interleukin_4 on CD25 + CD4 + regulatory T cell function .
11781710	0	CD25	55,59	latent_membrane_protein-1	19,44	CD25	latent membrane protein-1	3559	9260	Gene	Gene	expression|nummod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Epstein-Barr_virus latent_membrane_protein-1 activates CD25 expression in lymphoma cells involving the NFkappaB pathway .
18270248	0	CD25	42,46	mTOR	150,154	CD25	mTOR	3559	21977(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY induction|nmod|Foxp3 +|nsubj|induction +|nmod|administration administration|acl|accompanied accompanied|nmod|blockade blockade|nmod|END_ENTITY	De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR .
17875988	0	CD25	25,29	p53	82,85	CD25	p53	16184(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|acl|+ +|nmod|cells cells|nmod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD25	65,69	p53	82,85	CD25	p53	16184(Tax:10090)	22060(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
18462346	0	CD25	63,67	prion_protein	13,26	CD25	prion protein	16184(Tax:10090)	19122(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
20382886	0	CD25	59,63	programmed_death-1	107,125	CD25	programmed death-1	16184(Tax:10090)	18566(Tax:10090)	Gene	Gene	+|compound|START_ENTITY function|nmod|+ augment|iobj|function augment|parataxis|involvement involvement|nmod|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
24339053	0	CD25	145,149	tumor_necrosis_factor	18,39	CD25	tumor necrosis factor	16184(Tax:10090)	21926(Tax:10090)	Gene	Gene	+|compound|START_ENTITY pulmonary_fibrosis|nmod|+ inhibition|nmod|pulmonary_fibrosis contributes|xcomp|inhibition END_ENTITY|ccomp|contributes	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
8783262	0	CD26	154,158	Adenosine_deaminase	0,19	CD26	Adenosine deaminase	13482(Tax:10090)	11486(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY eminence|nmod|protein eminence|amod|END_ENTITY	Adenosine_deaminase in rodent median eminence : detection by antibody to the mouse enzyme and co-localization with adenosine_deaminase-complexing protein -LRB- CD26 -RRB- .
9103436	0	CD26	37,41	Adenosine_deaminase	0,19	CD26	Adenosine deaminase	1803	100	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Adenosine_deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles .
23792457	0	CD26	44,48	CD164	0,5	CD26	CD164	1803	8763	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CD164 and FCRL3 are highly expressed on CD4 + CD26 - T cells in S __ zary_syndrome patients .
16863912	0	CD26	42,46	CD34	110,114	CD26	CD34	1803	947	Gene	Gene	peptidase|compound|START_ENTITY upregulation|nmod|peptidase downregulates|nsubj|upregulation downregulates|dobj|response response|nmod|CD38 CD38|compound|END_ENTITY	G-CSF - and GM-CSF-induced upregulation of CD26 peptidase downregulates the functional chemotactic response of CD34 + CD38 - human cord blood hematopoietic cells .
17610364	0	CD26	14,18	CD34	39,43	CD26	CD34	1803	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Inhibition of CD26 in human cord blood CD34 + cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice .
17610365	0	CD26	0,4	CD34	19,23	CD26	CD34	1803	947	Gene	Gene	inhibition|nummod|START_ENTITY inhibition|nmod|hematopoietic hematopoietic|compound|END_ENTITY	CD26 inhibition on CD34 + or lineage - human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-term engraftment into NOD/SCID/Beta2null immunodeficient mice .
10899322	0	CD26	63,67	CD4	96,99	CD26	CD4	1803	920	Gene	Gene	START_ENTITY|nmod|mechanism mechanism|acl|modulated modulated|nmod|END_ENTITY	The HIV-1 gp120 inhibits the binding of adenosine_deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression .
16197392	0	CD26	11,15	CD4	47,50	CD26	CD4	1803	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Absence of CD26 expression on skin-homing CLA + CD4 + T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with S __ zary_syndrome .
16320722	0	CD26	0,4	CD4	7,10	CD26	CD4	1803	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	CD26 + CD4 + T cell counts and attack risk in interferon-treated multiple_sclerosis .
17081623	0	CD26	32,36	CD4	0,3	CD26	CD4	1803	920	Gene	Gene	expression|compound|START_ENTITY cells|nmod|expression cells|compound|END_ENTITY	CD4 -LRB- + -RRB- memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple_sclerosis .
18460019	0	CD26	0,4	CD4	19,22	CD26	CD4	1803	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	CD26 expression on CD4 + T cells in patients with cutaneous_leishmaniasis .
21887518	0	CD26	139,143	CD4	105,108	CD26	CD4	1803	920	Gene	Gene	expressing|dobj|START_ENTITY differentiated|xcomp|expressing differentiated|nmod|+ +|compound|END_ENTITY	Altered proportions of na ve , central_memory and terminally differentiated central_memory subsets among CD4 + and CD8 + T cells expressing CD26 in patients with type 1 diabetes .
22252752	0	CD26	132,136	CD4	171,174	CD26	CD4	1803	920	Gene	Gene	+|compound|START_ENTITY expression|appos|+ expression|appos|markers markers|nmod|+ +|compound|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
24627194	0	CD26	21,25	CD4	15,18	CD26	CD4	1803	920	Gene	Gene	CD38|compound|START_ENTITY CD38|amod|END_ENTITY	Flow cytometry CD4 -LRB- + -RRB- CD26 -LRB- - -RRB- CD38 -LRB- + -RRB- lymphocyte subset in the microenvironment of Hodgkin_lymphoma-affected lymph nodes .
25786689	0	CD26	59,63	CD4	64,67	CD26	CD4	1803	920	Gene	Gene	pulmonary_graft-versus-host_disease|nmod|START_ENTITY T|amod|pulmonary_graft-versus-host_disease T|compound|END_ENTITY	Regulation of pulmonary_graft-versus-host_disease by IL-26 + CD26 + CD4 T lymphocytes .
7665988	0	CD26	47,51	CD4	17,20	CD26	CD4	1803	920	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Costimulation Costimulation|nmod|+ +|compound|END_ENTITY	Costimulation of CD4 + and CD8 + T cells through CD26 : the ADA-binding epitope is not essential for complete signaling .
7903479	0	CD26	27,31	CD4	67,70	CD26	CD4	1803	920	Gene	Gene	antigen|appos|START_ENTITY antigen|nmod|cofactor cofactor|nmod|entry entry|nmod|HIV HIV|nmod|cells cells|nummod|+ +|compound|END_ENTITY	T cell activation antigen , CD26 , as a cofactor for entry of HIV in CD4 + cells .
8806567	0	CD26	101,105	CD4	109,112	CD26	CD4	1803	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4 + T cells .
9183643	0	CD26	8,12	CD4	17,20	CD26	CD4	1803	920	Gene	Gene	START_ENTITY|nmod|memory memory|compound|END_ENTITY	Role of CD26 for CD4 memory T cell function and activation .
9729533	0	CD26	28,32	CD4	36,39	CD26	CD4	1803	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Low relative frequencies of CD26 -LRB- + -RRB- CD4 -LRB- + -RRB- cells in long-term nonprogressing human_immunodeficiency_virus_type_1-infected subjects .
22252752	0	CD26	132,136	CD71	106,110	CD26	CD71	1803	7037	Gene	Gene	+|compound|START_ENTITY expression|appos|+ expression|appos|+ +|compound|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
24466195	0	CD26	25,29	CD9	0,3	CD26	CD9	1803	928	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CD9 negatively regulates CD26 expression and inhibits CD26-mediated enhancement of invasive potential of malignant_mesothelioma cells .
16197392	0	CD26	11,15	CLA	42,45	CD26	CLA	1803	6404	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Absence of CD26 expression on skin-homing CLA + CD4 + T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with S __ zary_syndrome .
25406260	0	CD26	89,93	DPP-IV	82,88	CD26	DPP-IV	1803	1803	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	High Fat Meal Leads to Decreased Insulinogenesis _ Incretin levels With Increased DPP-IV , CD26 Expression _ Glucagon levels versus a High fruit and Fiber Meal .
7974009	0	CD26	37,41	DPP4	25,29	CD26	DPP4	1803	1803	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Regional localization of DPP4 -LRB- alias CD26 and ADCP2 -RRB- to chromosome 2q24 .
10849736	0	CD26	98,102	DP_IV	92,97	CD26	DP IV	1803	1803	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	A new type of fluorogenic substrates for determination of cellular dipeptidyl_peptidase_IV -LRB- DP_IV / CD26 -RRB- activity .
12715075	0	CD26	25,29	Dipeptidyl_peptidase_IV	0,23	CD26	Dipeptidyl peptidase IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- CD26 -RRB- activity in the hematopoietic system : differences between the membrane-anchored and the released enzyme activity .
9269038	0	CD26	25,29	Dipeptidyl_peptidase_IV	0,23	CD26	Dipeptidyl peptidase IV	1803	1803	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- CD26 -RRB- activity in human alloreactive T cell subsets varies with the stage of differentiation and activation status .
25548232	0	CD26	80,84	EGR2	27,31	CD26	EGR2	1803	1959	Gene	Gene	Pathway|compound|START_ENTITY Induction|nmod|Pathway Induction|nmod|END_ENTITY	CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway .
7907293	0	CD26	61,65	adenosine_deaminase	11,30	CD26	adenosine deaminase	1803	100	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of adenosine_deaminase to the lymphocyte surface via CD26 .
8101391	0	CD26	76,80	adenosine_deaminase	22,41	CD26	adenosine deaminase	1803	100	Gene	Gene	antigen|appos|START_ENTITY association|nmod|antigen association|nmod|END_ENTITY	Direct association of adenosine_deaminase with a T cell activation antigen , CD26 .
8568233	0	CD26	57,61	adenosine_deaminase	20,39	CD26	adenosine deaminase	1803	100	Gene	Gene	binding|nmod|START_ENTITY cells|amod|binding cells|amod|END_ENTITY	Characterization of adenosine_deaminase binding to human CD26 on T cells and its biologic role in immune response .
9330696	0	CD26	84,88	adenosine_deaminase	47,66	CD26	adenosine deaminase	1803	100	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|xcomp|binding	HIV-1 envelope gp120 and viral particles block adenosine_deaminase binding to human CD26 .
16107720	0	CD26	0,4	caveolin-1	53,63	CD26	caveolin-1	1803	857	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells .
9760177	0	CD26	109,113	dipeptidyl-peptidase_IV	73,96	CD26	dipeptidyl-peptidase IV	1803	1803	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Dipeptidyl-peptidase_IV-beta -- further characterization and comparison to dipeptidyl-peptidase_IV activity of CD26 .
10849736	0	CD26	98,102	dipeptidyl_peptidase_IV	67,90	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	A new type of fluorogenic substrates for determination of cellular dipeptidyl_peptidase_IV -LRB- DP_IV / CD26 -RRB- activity .
10998079	0	CD26	40,44	dipeptidyl_peptidase_IV	15,38	CD26	dipeptidyl peptidase IV	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Elevated serum dipeptidyl_peptidase_IV -LRB- CD26 , EC 3.4.14.5 -RRB- activity in experimental liver_cirrhosis .
12182835	0	CD26	80,84	dipeptidyl_peptidase_IV	56,79	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression , purification , and characterization of human dipeptidyl_peptidase_IV / CD26 in Sf9 insect cells .
12752434	0	CD26	44,48	dipeptidyl_peptidase_IV	19,42	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Different modes of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites .
1358482	0	CD26	45,49	dipeptidyl_peptidase_IV	20,43	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- from human lymphocytes .
1371820	0	CD26	32,36	dipeptidyl_peptidase_IV	38,61	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biochemical characterization of CD26 -LRB- dipeptidyl_peptidase_IV -RRB- : functional comparison of distinct epitopes recognized by various anti-CD26 monoclonal antibodies .
1374571	0	CD26	14,18	dipeptidyl_peptidase_IV	20,43	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD26 -LRB- dipeptidyl_peptidase_IV -RRB- on memory and naive T lymphocytes .
17592366	0	CD26	53,57	dipeptidyl_peptidase_IV	21,44	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Serum and intestinal dipeptidyl_peptidase_IV -LRB- DPP_IV / CD26 -RRB- activity in children with celiac_disease .
18508427	0	CD26	59,63	dipeptidyl_peptidase_IV	35,58	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	activity|compound|START_ENTITY activity|nummod|END_ENTITY	Non-substrate peptides influencing dipeptidyl_peptidase_IV / CD26 activity and immune cell function .
7833626	0	CD26	59,63	dipeptidyl_peptidase_IV	34,57	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Expression and functional role of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- on human natural killer cells .
7909722	0	CD26	37,41	dipeptidyl_peptidase_IV	12,35	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Function of dipeptidyl_peptidase_IV -LRB- CD26 , Tp103 -RRB- in transfected human T cells .
7927537	0	CD26	77,81	dipeptidyl_peptidase_IV	83,106	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization , exact localization , and tissue expression of the human CD26 -LRB- dipeptidyl_peptidase_IV -RRB- gene .
9204385	0	CD26	39,43	dipeptidyl_peptidase_IV	14,37	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- by peptide boronic_acid_dipeptides .
9605992	0	CD26	64,68	dipeptidyl_peptidase_IV	39,62	CD26	dipeptidyl peptidase IV	1803	1803	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Multicolor cytoenzymatic evaluation of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- function in normal and neoplastic human T-lymphocyte populations .
15359642	0	CD27	46,50	CD19	38,42	CD27	CD19	939	930	Gene	Gene	cells|nummod|START_ENTITY +|dep|cells +|compound|END_ENTITY	In multiple_myeloma clonotypic CD38 - / CD19 + / CD27 + memory B cells recirculate through bone marrow , peripheral blood and lymph nodes .
23189166	0	CD27	41,45	CD19	26,30	CD27	CD19	939	930	Gene	Gene	START_ENTITY|amod|Decrease Decrease|nmod|proportion proportion|nmod|END_ENTITY	Decrease in proportion of CD19 + CD24 -LRB- hi -RRB- CD27 + B cells and impairment of their suppressive function in Graves ' _ disease .
23911852	0	CD27	144,148	CD19	117,121	CD27	CD19	939	930	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
24951896	0	CD27	36,40	CD19	17,21	CD27	CD19	939	930	Gene	Gene	IgG|dep|START_ENTITY IgG|compound|END_ENTITY	Double negative -LRB- CD19 -LRB- + -RRB- IgG -LRB- + -RRB- IgD -LRB- - -RRB- CD27 -LRB- - -RRB- -RRB- B lymphocytes : A new insight from telomerase in healthy elderly , in centenarian offspring and in Alzheimer 's _ disease patients .
25899086	0	CD27	26,30	CD19	33,37	CD27	CD19	939	930	Gene	Gene	percentage|nmod|START_ENTITY END_ENTITY|nsubj|percentage	Low percentage of CD24 -LRB- hi -RRB- CD27 -LRB- + -RRB- CD19 -LRB- + -RRB- B cells decelerates gastric_cancer progression in XELOX-treated patients .
21220451	0	CD27	94,98	CD20	88,92	CD27	CD20	939	54474	Gene	Gene	CD70|compound|START_ENTITY CD70|compound|END_ENTITY	Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 + CD27 + CD43 + CD70 - .
22553348	0	CD27	54,58	CD20	0,4	CD27	CD20	939	54474	Gene	Gene	have|dobj|START_ENTITY have|nsubj|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	CD20 + tumor-infiltrating lymphocytes have an atypical CD27 - memory phenotype and together with CD8 + T cells promote favorable prognosis in ovarian_cancer .
22566872	0	CD27	79,83	CD20	38,42	CD27	CD20	939	54474	Gene	Gene	B-cells|compound|START_ENTITY induces|nmod|B-cells induces|dobj|generation generation|nmod|plasmablasts plasmablasts|compound|END_ENTITY	TLR9 ligand induces the generation of CD20 + plasmablasts and plasma cells from CD27 + memory B-cells .
23911852	0	CD27	144,148	CD20	124,128	CD27	CD20	939	54474	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
21304587	0	CD27	21,25	CD21	16,20	CD27	CD21	939	1380	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Double-positive CD21 + CD27 + B cells are highly proliferating memory cells and their distribution differs in mucosal and peripheral tissues .
21622026	0	CD27	132,136	CD21	127,131	CD27	CD21	712693(Tax:9544)	1380	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Simian_immunodeficiency_virus infection in rhesus_macaques induces selective tissue specific B cell defects in double positive CD21 + CD27 + memory B cells .
16210336	0	CD27	67,71	CD25	93,97	CD27	CD25	939	3559	Gene	Gene	subset|compound|START_ENTITY subset|nmod|cells cells|compound|END_ENTITY	Rapamycin , and not cyclosporin_A , preserves the highly suppressive CD27 + subset of human CD4 + CD25 + regulatory T cells .
17425604	0	CD27	0,4	CD25	121,125	CD27	CD25	939	3559	Gene	Gene	expression|compound|START_ENTITY discriminates|nsubj|expression discriminates|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4 + CD25 + cells .
15198732	0	CD27	35,39	CD28	40,44	CD27	CD28	939	940	Gene	Gene	CCR7|compound|START_ENTITY CCR7|compound|END_ENTITY	Characteristic expansion of CD45RA CD27 CD28 CCR7 lymphocytes with stable natural_killer _ -LRB- NK -RRB- _ receptor expression in NK - and T-cell type lymphoproliferative_disease_of_granular_lymphocytes .
15345595	0	CD27	45,49	CD28	51,55	CD27	CD28	939	940	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Transition of late-stage effector T cells to CD27 + CD28 + tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy .
23402380	0	CD27	32,36	CD28	38,42	CD27	CD28	939	940	Gene	Gene	tumor|compound|START_ENTITY tumor|compound|END_ENTITY	IL-21 promotes the expansion of CD27 + CD28 + tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells .
7634349	0	CD27	16,20	CD28	40,44	CD27	CD28	939	940	Gene	Gene	Crosslinking|nmod|START_ENTITY Crosslinking|nmod|presence presence|nmod|results results|compound|END_ENTITY	Crosslinking of CD27 in the presence of CD28 costimulation results in T cell proliferation and cytokine production .
1348033	0	CD27	4,8	CD4	44,47	CD27	CD4	939	920	Gene	Gene	START_ENTITY|parataxis|contains contains|nsubj|subset subset|nmod|lymphocytes lymphocytes|compound|END_ENTITY	The CD27 - subset of peripheral blood memory CD4 + lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo .
1358967	0	CD27	0,4	CD4	98,101	CD27	CD4	939	920	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|clones clones|compound|END_ENTITY	CD27 , a member of the nerve growth factor receptor family , is preferentially expressed on CD45RA + CD4 T cell clones and involved in distinct immunoregulatory functions .
14984597	0	CD27	98,102	CD4	143,146	CD27	CD4	939	920	Gene	Gene	expression|nmod|START_ENTITY changes|nmod|expression changes|nmod|naive naive|acl:relcl|regulated regulated|nsubjpass|cells cells|compound|END_ENTITY	Automatic generation of lymphocyte heterogeneity : Division-dependent changes in the expression of CD27 , CCR7 and CD45 by activated human naive CD4 + T cells are independently regulated .
15500623	0	CD27	0,4	CD4	6,9	CD27	CD4	939	920	Gene	Gene	START_ENTITY|parataxis|define define|nsubj|cells cells|compound|END_ENTITY	CD27 - CD4 + memory T cells define a differentiated memory population at both the functional and transcriptional levels .
16210336	0	CD27	67,71	CD4	89,92	CD27	CD4	939	920	Gene	Gene	subset|compound|START_ENTITY subset|nmod|cells cells|compound|END_ENTITY	Rapamycin , and not cyclosporin_A , preserves the highly suppressive CD27 + subset of human CD4 + CD25 + regulatory T cells .
17118766	0	CD27	14,18	CD4	33,36	CD27	CD4	939	920	Gene	Gene	START_ENTITY|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Expression of CD27 on peripheral CD4 + T-lymphocytes correlates with the development of severe acute_graft-versus-host_disease after allogeneic bone marrow transplantation .
17425604	0	CD27	0,4	CD4	116,119	CD27	CD4	939	920	Gene	Gene	expression|compound|START_ENTITY discriminates|nsubj|expression discriminates|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4 + CD25 + cells .
17453966	0	CD27	38,42	CD4	23,26	CD27	CD4	939	920	Gene	Gene	Foxp3|compound|START_ENTITY enriches|dobj|Foxp3 enriches|nmod|CD25 CD25|compound|END_ENTITY	Rapamycin enriches for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD27 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple_sclerosis .
18182812	0	CD27	83,87	CD4	29,32	CD27	CD4	939	920	Gene	Gene	analysis|nummod|START_ENTITY subsets|dep|analysis subsets|nummod|END_ENTITY	Heterogeneity of circulating CD4 + memory T-cell subsets in erythrodermic patients : CD27 analysis can help to distinguish cutaneous_T-cell_lymphomas from inflammatory erythroderma .
18506879	0	CD27	57,61	CD4	0,3	CD27	CD4	939	920	Gene	Gene	expression|compound|START_ENTITY memory|nmod|expression improves|dobj|memory improves|nsubj|help help|compound|END_ENTITY	CD4 + T cell help improves CD8 + T cell memory by retained CD27 expression .
18606659	0	CD27	0,4	CD4	15,18	CD27	CD4	939	920	Gene	Gene	instructs|nsubj|START_ENTITY instructs|dobj|cells cells|compound|END_ENTITY	CD27 instructs CD4 + T cells to provide help for the memory CD8 + T cell response after protein immunization .
19454729	0	CD27	0,4	CD4	19,22	CD27	CD4	939	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD27 expression on CD4 + T cells differentiates effector from regulatory T cell subsets in the lung .
21214539	0	CD27	94,98	CD4	83,86	CD27	CD4	939	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cytomegalovirus_infection induces the accumulation of short-lived , multifunctional CD4 + CD45RA + CD27 + T cells : the potential involvement of interleukin-7 in this process .
21220773	0	CD27	59,63	CD4	14,17	CD27	CD4	939	920	Gene	Gene	numbers|nmod|START_ENTITY numbers|compound|END_ENTITY	Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic_hepatitis_C_virus_infection .
24391889	0	CD27	7,11	CD4	106,109	CD27	CD4	939	920	Gene	Gene	percentages|compound|START_ENTITY predict|nsubj|percentages predict|dobj|recovery recovery|compound|END_ENTITY	Higher CD27 + CD8 + T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4 + T cell recovery in treated HIV_infection .
26818544	0	CD27	28,32	CD4	0,3	CD27	CD4	939	920	Gene	Gene	cells|compound|START_ENTITY activate|dobj|cells activate|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
27020860	0	CD27	0,4	CD4	46,49	CD27	CD4	100520023	404704(Tax:9823)	Gene	Gene	agonism|compound|START_ENTITY recapitulates|nsubj|agonism recapitulates|dobj|help help|compound|END_ENTITY	CD27 agonism plus PD-1 blockade recapitulates CD4 + T cell help in therapeutic anti-cancer vaccination .
7923389	0	CD27	27,31	CD4	57,60	CD27	CD4	939	920	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|subsets subsets|nmod|cells cells|compound|END_ENTITY	Differential regulation of CD27 expression on subsets of CD4 T cells .
14556986	0	CD27	0,4	CD40	21,25	CD27	CD40	939	958	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	CD27 synergizes with CD40 to induce IgM , IgG , and IgA antibody responses of peripheral blood B cells in the presence of IL-2 and IL-10 .
21220451	0	CD27	94,98	CD43	100,104	CD27	CD43	939	6693	Gene	Gene	CD70|compound|START_ENTITY CD70|compound|END_ENTITY	Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 + CD27 + CD43 + CD70 - .
23911852	0	CD27	144,148	CD43	157,161	CD27	CD43	939	6693	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
12100033	0	CD27	50,54	CD70	26,30	CD27	CD70	939	970	Gene	Gene	naive|dep|START_ENTITY cells|amod|naive up-regulation|nmod|cells up-regulation|nmod|END_ENTITY	Impaired up-regulation of CD70 and CD86 in naive -LRB- CD27 - -RRB- B cells from patients with common_variable_immunodeficiency -LRB- CVID -RRB- .
12496380	0	CD27	25,29	CD70	37,41	CD27	CD70	21940(Tax:10090)	21948(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression of the murine CD27 ligand CD70 in vitro and in vivo .
23206232	0	CD27	143,147	CD70	14,18	CD27	CD70	939	970	Gene	Gene	proliferation|nmod|START_ENTITY role|nmod|proliferation Expression|dep|role Expression|nmod|END_ENTITY	Expression of CD70 in nasal natural killer/T _ cell_lymphoma cell lines and patients ; its role for cell proliferation through binding to soluble CD27 .
23911852	0	CD27	144,148	CD70	137,141	CD27	CD70	939	970	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
23913967	0	CD27	42,46	CD70	0,4	CD27	CD70	21940(Tax:10090)	21948(Tax:10090)	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nsubjpass|END_ENTITY	CD70 is downregulated by interaction with CD27 .
24211844	0	CD27	0,4	CD70	29,33	CD27	CD70	939	970	Gene	Gene	engagement|nummod|START_ENTITY engagement|nmod|protein protein|compound|END_ENTITY	CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-y secretion .
25691774	0	CD27	126,130	CD70	19,23	CD27	CD70	939	970	Gene	Gene	Lymphocytes|nmod|START_ENTITY Infiltration|nmod|Lymphocytes Associated|nmod|Infiltration Associated|nsubj|Expression Expression|compound|END_ENTITY	pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27 + Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear_Cell_Renal_Cell_Carcinoma .
25691774	0	CD27	70,74	CD70	19,23	CD27	CD70	939	970	Gene	Gene	Lymphocytes|compound|START_ENTITY Infiltration|nmod|Lymphocytes Associated|nmod|Infiltration Associated|nsubj|Expression Expression|compound|END_ENTITY	pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27 + Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear_Cell_Renal_Cell_Carcinoma .
7540066	0	CD27	14,18	CD70	35,39	CD27	CD70	939	970	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD27 and its ligand , CD70 , on chronic_lymphocytic_leukemia B cells .
8186199	0	CD27	37,41	CD70	0,4	CD27	CD70	939	970	Gene	Gene	ligand|nmod|START_ENTITY represents|dobj|ligand represents|nsubj|END_ENTITY	CD70 represents the human ligand for CD27 .
8977292	0	CD27	57,61	CD70	51,55	CD27	CD70	939	970	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|appos|ligand	Phenotype and function of human B cells expressing CD70 -LRB- CD27 ligand -RRB- .
9366422	0	CD27	78,82	CD70	27,31	CD27	CD70	21940(Tax:10090)	21948(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY Characterization|appos|ligand Characterization|nmod|END_ENTITY	Characterization of murine CD70 , the ligand of the TNF receptor family member CD27 .
12370498	0	CD27	45,49	CD8	51,54	CD27	CD8	939	925	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Lack of Epstein-Barr_virus - and HIV-specific CD27 - CD8 + T cells is associated with progression to viral_disease in HIV-infection .
12464570	0	CD27	71,75	CD8	47,50	CD27	CD8	939	925	Gene	Gene	provide|nsubj|START_ENTITY Failing|parataxis|provide Failing|nmod|result result|nmod|maturation maturation|compound|END_ENTITY	Failing immune control as a result of impaired CD8 + T-cell maturation : CD27 might provide a clue .
15048710	0	CD27	130,134	CD8	35,38	CD27	CD8	939	925	Gene	Gene	expression|nmod|START_ENTITY correlation|nmod|expression classification|dep|correlation classification|nmod|cells cells|compound|END_ENTITY	Phenotypic classification of human CD8 + T cells reflecting their function : inverse correlation between quantitative expression of CD27 and cytotoxic effector function .
17159138	0	CD27	0,4	CD8	64,67	CD27	CD8	939	925	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expansion expansion|nmod|cell cell|compound|END_ENTITY	CD27 mediates interleukin-2-independent clonal expansion of the CD8 + T cell without effector differentiation .
18506879	0	CD27	57,61	CD8	26,29	CD27	CD8	939	925	Gene	Gene	expression|compound|START_ENTITY memory|nmod|expression memory|compound|END_ENTITY	CD4 + T cell help improves CD8 + T cell memory by retained CD27 expression .
18606659	0	CD27	0,4	CD8	59,62	CD27	CD8	939	925	Gene	Gene	instructs|nsubj|START_ENTITY instructs|xcomp|provide provide|nmod|response response|nummod|END_ENTITY	CD27 instructs CD4 + T cells to provide help for the memory CD8 + T cell response after protein immunization .
21048108	0	CD27	85,89	CD8	67,70	CD27	CD8	939	925	Gene	Gene	costimulation|compound|START_ENTITY signaling|nmod|costimulation signaling|nmod|cells cells|compound|END_ENTITY	The Pim kinase pathway contributes to survival signaling in primed CD8 + T cells upon CD27 costimulation .
22553348	0	CD27	54,58	CD8	95,98	CD27	CD8	939	925	Gene	Gene	have|dobj|START_ENTITY have|advmod|together together|nmod|cells cells|compound|END_ENTITY	CD20 + tumor-infiltrating lymphocytes have an atypical CD27 - memory phenotype and together with CD8 + T cells promote favorable prognosis in ovarian_cancer .
23017234	0	CD27	82,86	CD8	90,93	CD27	CD8	939	925	Gene	Gene	T-cells|amod|START_ENTITY T-cells|compound|END_ENTITY	Acute aerobic exercise in humans increases cytokine expression in CD27 -LRB- - -RRB- but not CD27 -LRB- + -RRB- CD8 -LRB- + -RRB- T-cells .
24002868	0	CD27	0,4	CD8	83,86	CD27	CD8	939	925	Gene	Gene	costimulation|compound|START_ENTITY contributes|nsubj|costimulation contributes|dobj|cells cells|amod|substantially substantially|nmod|expansion expansion|nmod|T T|compound|END_ENTITY	CD27 costimulation contributes substantially to the expansion of functional memory CD8 -LRB- + -RRB- T cells after peptide immunization .
24391889	0	CD27	7,11	CD8	12,15	CD27	CD8	939	925	Gene	Gene	percentages|compound|START_ENTITY percentages|compound|END_ENTITY	Higher CD27 + CD8 + T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4 + T cell recovery in treated HIV_infection .
24860188	0	CD27	23,27	CD8	75,78	CD27	CD8	939	925	Gene	Gene	impact|nmod|START_ENTITY costimulation|nsubj|impact costimulation|dobj|generation generation|compound|END_ENTITY	Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization .
23402380	0	CD27	32,36	IL-21	0,5	CD27	IL-21	939	59067	Gene	Gene	tumor|compound|START_ENTITY expansion|nmod|tumor promotes|dobj|expansion promotes|nsubj|END_ENTITY	IL-21 promotes the expansion of CD27 + CD28 + tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells .
26818544	0	CD27	28,32	IL-21	50,55	CD27	IL-21	939	59067	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
10419648	0	CD27	0,4	PKC	21,24	CD27	PKC	939	112476	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	CD27 signals through PKC in human B_cell_lymphomas .
10597319	0	CD27	86,90	Siva	62,66	CD27	Siva	21940(Tax:10090)	30954(Tax:10090)	Gene	Gene	bind|nmod|START_ENTITY apoptosis|compound|bind Siva-1|appos|apoptosis Siva-1|appos|forms forms|nmod|gene gene|compound|END_ENTITY	Murine Siva-1 and Siva-2 , alternate splice forms of the mouse Siva gene , both bind to CD27 but differentially transduce apoptosis .
9177220	0	CD27	0,4	Siva	92,96	CD27	Siva	939	10572	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	CD27 , a member of the tumor necrosis factor receptor family , induces apoptosis and binds to Siva , a proapoptotic protein .
21214539	0	CD27	94,98	interleukin-7	138,151	CD27	interleukin-7	939	3574	Gene	Gene	cells|compound|START_ENTITY cells|dep|involvement involvement|nmod|END_ENTITY	Cytomegalovirus_infection induces the accumulation of short-lived , multifunctional CD4 + CD45RA + CD27 + T cells : the potential involvement of interleukin-7 in this process .
25697485	0	CD274	33,38	PD-L1	26,31	CD274	PD-L1	29126	29126	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TLR3 triggering regulates PD-L1 -LRB- CD274 -RRB- expression in human neuroblastoma cells .
19088198	0	CD274	87,92	STAT3	41,46	CD274	STAT3	29126	6774	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 -LRB- PD-L1 , B7-H1 -RRB- .
11745696	0	CD27L	94,99	CD30L	87,92	CD27L	CD30L	21948(Tax:10090)	21949(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumour necrosis factor -LRB- TNF -RRB- ligand superfamily co-stimulatory molecules CD30L , CD27L , OX40L , and 4-1BBL in murine hearts with acute_myocarditis caused by Coxsackievirus B3 .
12031769	0	CD27L	79,84	CD30L	86,91	CD27L	CD30L	970	944	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L , CD30L , OX40L and 4-1BBL in the heart of patients with acute_myocarditis and dilated_cardiomyopathy .
9550398	0	CD27L	30,35	CD40	0,4	CD27L	CD40	21948(Tax:10090)	21939(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	CD40 and IL-4 regulate murine CD27L expression .
11745696	0	CD27L	94,99	OX40L	101,106	CD27L	OX40L	21948(Tax:10090)	22164(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumour necrosis factor -LRB- TNF -RRB- ligand superfamily co-stimulatory molecules CD30L , CD27L , OX40L , and 4-1BBL in murine hearts with acute_myocarditis caused by Coxsackievirus B3 .
12031769	0	CD27L	79,84	OX40L	93,98	CD27L	OX40L	970	7292	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L , CD30L , OX40L and 4-1BBL in the heart of patients with acute_myocarditis and dilated_cardiomyopathy .
14707071	0	CD28	31,35	4-1BB	39,44	CD28	4-1BB	12487(Tax:10090)	21942(Tax:10090)	Gene	Gene	switch|nmod|START_ENTITY switch|nmod|END_ENTITY	A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo .
17878391	0	CD28	21,25	4-1BB	0,5	CD28	4-1BB	940	3604	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	4-1BB is superior to CD28 costimulation for generating CD8 + cytotoxic lymphocytes for adoptive immunotherapy .
1847724	0	CD28	4,8	B7/BB1	16,22	CD28	B7/BB1	940	941	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|provides provides|nsubj|END_ENTITY	The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4 + T cells .
7678229	0	CD28	23,27	B7/BB1	0,6	CD28	B7/BB1	940	941	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	B7/BB1 , the ligand for CD28 , is expressed on repeatedly activated human T cells in vitro .
15647361	0	CD28	37,41	B_and_T_lymphocyte_attenuator	74,103	CD28	B and T lymphocyte attenuator	940	151888	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	A coreceptor interaction between the CD28 and TNF_receptor family members B_and_T_lymphocyte_attenuator and herpesvirus entry mediator .
25637021	0	CD28	0,4	CAPRI	44,49	CD28	CAPRI	940	10156	Gene	Gene	Adhesion|compound|START_ENTITY Adhesion|nmod|END_ENTITY	CD28 Inhibits T Cell Adhesion by Recruiting CAPRI to the Plasma Membrane .
12865065	0	CD28	55,59	CCR5	15,19	CD28	CCR5	940	1234	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Differences in CCR5 expression on peripheral blood CD4 + CD28 - T-cells and in granulomatous_lesions between localized and generalized Wegener 's _ granulomatosis .
23747721	0	CD28	85,89	CCR7	64,68	CD28	CCR7	940	1236	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD45RA-Foxp3 -LRB- high -RRB- activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28 + central memory subset are decreased in peripheral blood from patients with rheumatoid_arthritis .
11035618	0	CD28	23,27	CD11b	29,34	CD28	CD11b	940	3684	Gene	Gene	Expansion|nmod|START_ENTITY Expansion|dep|END_ENTITY	Expansion of rare CD8 + CD28 - CD11b - T cells with impaired effector functions in HIV-1-infected patients .
11145666	0	CD28	32,36	CD11b	0,5	CD28	CD11b	940	3684	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T identifies|ccomp|lymphocytes identifies|nsubj|expression expression|amod|END_ENTITY	CD11b expression identifies CD8 + CD28 + T lymphocytes with phenotype and function of both naive/memory and effector cells .
10458478	0	CD28	110,114	CD2	106,109	CD28	CD2	25660(Tax:10116)	497761(Tax:10116)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Better-surviving liver grafts by the injection of anti-CD2 antibody : the important roles of host CD8 + and CD2 + CD28 + T cells in chronic graft rejection and beta_type_platelet-derived_growth_factor_receptor -LRB- PDGFR-beta -RRB- expression on apoptotic liver grafts .
1670946	0	CD28	67,71	CD2	58,61	CD28	CD2	940	914	Gene	Gene	pathways|nummod|START_ENTITY pathways|nummod|END_ENTITY	IL-1_alpha is produced by T lymphocytes activated via the CD2 plus CD28 pathways .
1968076	0	CD28	81,85	CD2	70,73	CD28	CD2	940	914	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	`` CD3low '' human thymocyte populations can readily be triggered via the CD2 and/or CD28 activation pathways whereas the CD3 pathway remains nonfunctional .
7915976	0	CD28	104,108	CD2	80,83	CD28	CD2	940	914	Gene	Gene	CD43|dep|START_ENTITY CD43|compound|END_ENTITY	Primary T lymphocyte immunodeficiency associated with a selective impairment of CD2 , CD3 , CD43 -LRB- but not CD28 -RRB- - mediated signal transduction .
8902857	0	CD28	141,145	CD2	132,135	CD28	CD2	940	914	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Enhanced production of IL4 but not of IFN_gamma and IL_10 by peripheral blood mononuclear cells from atopic children in response to CD2 plus CD28 stimulation .
14500627	0	CD28	14,18	CD25	58,62	CD28	CD25	12487(Tax:10090)	16184(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|homeostasis homeostasis|nmod|cells cells|compound|END_ENTITY	Cutting edge : CD28 controls peripheral homeostasis of CD4 + CD25 + regulatory T cells .
14609212	0	CD28	12,16	CD25	66,70	CD28	CD25	12487(Tax:10090)	16184(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|cells cells|compound|END_ENTITY	The role of CD28 and CTLA4 in the function and homeostasis of CD4 + CD25 + regulatory T cells .
15016653	0	CD28	0,4	CD25	90,94	CD28	CD25	12487(Tax:10090)	16184(Tax:10090)	Gene	Gene	disruption|compound|START_ENTITY exacerbates|nsubj|disruption exacerbates|dobj|inflammation inflammation|nmod|suppression suppression|nmod|cells cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
16338210	0	CD28	0,4	CD25	80,84	CD28	CD25	940	3559	Gene	Gene	superagonists|compound|START_ENTITY put|nsubj|superagonists put|nmod|cells cells|compound|END_ENTITY	CD28 superagonists put a break on autoimmunity by preferentially activating CD4 + CD25 + regulatory T cells .
16699464	0	CD28	119,123	CD25	66,70	CD28	CD25	940	3559	Gene	Gene	costimulation|compound|START_ENTITY bypassing|dobj|costimulation END_ENTITY|acl|bypassing	A divalent human leukocyte antigen-B7 fusion-protein up-regulates CD25 and CD69 in alloreactive CD8 + T cells bypassing CD28 costimulation .
17038912	0	CD28	15,19	CD25	108,112	CD28	CD25	12487(Tax:10090)	16184(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY converted|nsubj|Requirement converted|dobj|Tregs Tregs|nmod|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD28	15,19	CD25	80,84	CD28	CD25	12487(Tax:10090)	16184(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY converted|nsubj|Requirement converted|dobj|Tregs Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
18780874	0	CD28	36,40	CD25	42,46	CD28	CD25	940	3559	Gene	Gene	frequency|nmod|START_ENTITY frequency|dep|lymphocytes lymphocytes|nummod|END_ENTITY	The frequency of regulatory CD3 + CD8 + CD28 - CD25 + T lymphocytes in human peripheral blood increases with age .
19949106	0	CD28	56,60	CD25	6,10	CD28	CD25	940	3559	Gene	Gene	form|nmod|START_ENTITY resist|dobj|form regulatory|ccomp|resist regulatory|nsubj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells resist a novel form of CD28 - and Fas-dependent p53-induced T cell apoptosis .
15198732	0	CD28	40,44	CD27	35,39	CD28	CD27	940	939	Gene	Gene	CCR7|compound|START_ENTITY CCR7|compound|END_ENTITY	Characteristic expansion of CD45RA CD27 CD28 CCR7 lymphocytes with stable natural_killer _ -LRB- NK -RRB- _ receptor expression in NK - and T-cell type lymphoproliferative_disease_of_granular_lymphocytes .
15345595	0	CD28	51,55	CD27	45,49	CD28	CD27	940	939	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Transition of late-stage effector T cells to CD27 + CD28 + tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy .
23402380	0	CD28	38,42	CD27	32,36	CD28	CD27	940	939	Gene	Gene	tumor|compound|START_ENTITY tumor|compound|END_ENTITY	IL-21 promotes the expansion of CD27 + CD28 + tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells .
7634349	0	CD28	40,44	CD27	16,20	CD28	CD27	940	939	Gene	Gene	results|compound|START_ENTITY presence|nmod|results Crosslinking|nmod|presence Crosslinking|nmod|END_ENTITY	Crosslinking of CD27 in the presence of CD28 costimulation results in T cell proliferation and cytokine production .
10331493	0	CD28	135,139	CD28	56,60	CD28	CD28	940	940	Gene	Gene	number|nmod|START_ENTITY accounting|nmod|number Generation|dep|accounting Generation|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD28	14,18	CD28	56,60	CD28	CD28	940	940	Gene	Gene	Generation|nmod|START_ENTITY Generation|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD28	56,60	CD28	135,139	CD28	CD28	940	940	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Generation|dep|cells Generation|dep|accounting accounting|nmod|number number|nmod|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD28	56,60	CD28	14,18	CD28	CD28	940	940	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Generation|dep|cells Generation|nmod|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
12392852	0	CD28	56,60	CD28	77,81	CD28	CD28	940	940	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Proliferative_arrest and cell cycle regulation in CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- versus CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T cells .
12392852	0	CD28	77,81	CD28	56,60	CD28	CD28	940	940	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Proliferative_arrest and cell cycle regulation in CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- versus CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T cells .
12963692	0	CD28	15,19	CD28	34,38	CD28	CD28	940	940	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
12963692	0	CD28	34,38	CD28	15,19	CD28	CD28	940	940	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
22851040	0	CD28	16,20	CD28	29,33	CD28	CD28	940	940	Gene	Gene	+|compound|START_ENTITY Balance|nmod|+ END_ENTITY|dep|Balance	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	0	CD28	29,33	CD28	16,20	CD28	CD28	940	940	Gene	Gene	START_ENTITY|dep|Balance Balance|nmod|+ +|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
9498756	0	CD28	67,71	CD30	41,45	CD28	CD30	940	943	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines .
10458758	0	CD28	0,4	CD4	83,86	CD28	CD4	940	920	Gene	Gene	results|nummod|START_ENTITY results|nmod|down-regulation down-regulation|nmod|expression expression|nmod|END_ENTITY	CD28 co-stimulation results in down-regulation of lymphotactin expression in human CD4 -LRB- + -RRB- but not CD8 -LRB- + -RRB- T cells via an IL-2-dependent mechanism .
10798745	0	CD28	63,67	CD4	26,29	CD28	CD4	940	920	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|anergy anergy|compound|END_ENTITY	Induction of xenoreactive CD4 + T-cell anergy by suppressor CD8 + CD28 - T cells .
10925251	0	CD28	99,103	CD4	130,133	CD28	CD4	940	920	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|lymphocytes lymphocytes|compound|END_ENTITY	The NF-kappa_B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4 + lymphocytes .
11120881	0	CD28	77,81	CD4	116,119	CD28	CD4	940	920	Gene	Gene	absence|nmod|START_ENTITY lymphocyte_function-associated_antigen_1|nmod|absence ligation|amod|lymphocyte_function-associated_antigen_1 Costimulation|nmod|ligation promotes|nsubj|Costimulation promotes|dobj|anergy anergy|nmod|cells cells|compound|END_ENTITY	Costimulation via lymphocyte_function-associated_antigen_1 in the absence of CD28 ligation promotes anergy of naive CD4 + T cells .
11243699	0	CD28	91,95	CD4	140,143	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|deletion deletion|nmod|thymocytes thymocytes|compound|END_ENTITY	The affinity/avidity and length of exposure to the deleting ligand determine dependence on CD28 for the efficient deletion of self-specific CD4 + CD8 + thymocytes .
11318597	0	CD28	13,17	CD4	37,40	CD28	CD4	940	920	Gene	Gene	levels|compound|START_ENTITY define|nsubj|levels define|dobj|subsets subsets|compound|END_ENTITY	Cell surface CD28 levels define four CD4 + T cell subsets : abnormal expression in rheumatoid_arthritis .
11714791	0	CD28	59,63	CD4	8,11	CD28	CD4	100738615	404704(Tax:9823)	Gene	Gene	costimulation|nummod|START_ENTITY requires|dobj|costimulation requires|nmod|help help|compound|END_ENTITY	Without CD4 help , CD8 rejection of pig xenografts requires CD28 costimulation but not perforin killing .
12444145	0	CD28	51,55	CD4	62,65	CD28	CD4	940	920	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
12506015	0	CD28	0,4	CD4	23,26	CD28	CD4	940	920	Gene	Gene	loss|nummod|START_ENTITY loss|nmod|cells cells|compound|END_ENTITY	CD28 loss in senescent CD4 + T cells : reversal by interleukin-12 stimulation .
12586604	0	CD28	0,4	CD4	108,111	CD28	CD4	940	920	Gene	Gene	co-stimulation|compound|START_ENTITY regulates|nsubj|co-stimulation regulates|dobj|effect effect|nmod|cells cells|amod|transforming_growth_factor-beta1 transforming_growth_factor-beta1|nmod|proliferation proliferation|nmod|T T|compound|END_ENTITY	CD28 co-stimulation regulates the effect of transforming_growth_factor-beta1 on the proliferation of na ve CD4 + T cells .
12751030	0	CD28	19,23	CD4	15,18	CD28	CD4	940	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A low level of CD4 + CD28 + T cells is an independent predictor of high mortality in human_immunodeficiency_virus_type_1-infected patients .
1363054	0	CD28	26,30	CD4	52,55	CD28	CD4	940	920	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|T T|compound|END_ENTITY	A co-stimulatory role for CD28 in the activation of CD4 + T lymphocytes by staphylococcal_enterotoxin_B .
14500627	0	CD28	14,18	CD4	54,57	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|homeostasis homeostasis|nmod|cells cells|compound|END_ENTITY	Cutting edge : CD28 controls peripheral homeostasis of CD4 + CD25 + regulatory T cells .
14502004	0	CD28	39,43	CD4	45,48	CD28	CD4	940	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Nadir CD4 + T-cell count and numbers of CD28 + CD4 + T-cells predict functional responses to immunizations in chronic_HIV-1_infection .
14609212	0	CD28	12,16	CD4	62,65	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|cells cells|compound|END_ENTITY	The role of CD28 and CTLA4 in the function and homeostasis of CD4 + CD25 + regulatory T cells .
14980436	0	CD28	0,4	CD4	115,118	CD28	CD4	940	920	Gene	Gene	costimulation|compound|START_ENTITY enhances|nsubj|costimulation enhances|dobj|sensitivity sensitivity|nmod|assay assay|nmod|detection detection|nmod|END_ENTITY	CD28 costimulation enhances the sensitivity of the ELISPOT assay for detection of antigen-specific memory effector CD4 and CD8 cell populations in human diseases .
15016653	0	CD28	0,4	CD4	86,89	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	disruption|compound|START_ENTITY exacerbates|nsubj|disruption exacerbates|dobj|inflammation inflammation|nmod|suppression suppression|nmod|cells cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15048719	0	CD28	192,196	CD4	103,106	CD28	CD4	940	920	Gene	Gene	ligands|nummod|START_ENTITY expression|nmod|ligands involve|dobj|expression mechanism|acl:relcl|involve proliferation|nmod|mechanism proliferation|nmod|cells cells|compound|END_ENTITY	IL-1 acts on antigen-presenting cells to enhance the in vivo proliferation of antigen-stimulated naive CD4 T cells via a CD28-dependent mechanism that does not involve increased expression of CD28 ligands .
15142043	0	CD28	23,27	CD4	29,32	CD28	CD4	940	920	Gene	Gene	follow|nmod|START_ENTITY follow|parataxis|T T|nsubj|+ +|compound|END_ENTITY	Long time follow up of CD28 - CD4 + T cells in living kidney transplant patients .
15356139	0	CD28	11,15	CD4	56,59	CD28	CD4	940	920	Gene	Gene	role|nmod|START_ENTITY role|nmod|cells cells|compound|END_ENTITY	A role for CD28 in lymphopenia-induced_proliferation of CD4 T cells .
15488732	0	CD28	0,4	CD4	67,70	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|+ +|compound|END_ENTITY	CD28 is required for T cell activation and IFN-gamma production by CD4 + and CD8 + T cells in response to Trypanosoma_cruzi_infection .
15568615	0	CD28	24,28	CD4	71,74	CD28	CD4	940	920	Gene	Gene	effects|nmod|START_ENTITY costimulation|nsubj|effects costimulation|nmod|+ +|compound|END_ENTITY	Differential effects of CD28 costimulation upon cytokine production by CD4 + and CD8 + T cells .
16011533	0	CD28	17,21	CD4	47,50	CD28	CD4	940	920	Gene	Gene	Dysregulation|nmod|START_ENTITY expression|nsubj|Dysregulation expression|nmod|cells cells|compound|END_ENTITY	Dysregulation of CD28 and CTLA-4 expression by CD4 T cells from previously immunodeficient HIV-infected patients with sustained virological responses to highly active antiretroviral therapy .
16137665	0	CD28	0,4	CD4	85,88	CD28	CD4	940	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|nummod|END_ENTITY	CD28 regulates glucocorticoid-induced TNF receptor family-related gene expression on CD4 + T cells via IL-2-dependent mechanisms .
16338210	0	CD28	0,4	CD4	76,79	CD28	CD4	940	920	Gene	Gene	superagonists|compound|START_ENTITY put|nsubj|superagonists put|nmod|cells cells|compound|END_ENTITY	CD28 superagonists put a break on autoimmunity by preferentially activating CD4 + CD25 + regulatory T cells .
16339520	0	CD28	12,16	CD4	119,122	CD28	CD4	940	920	Gene	Gene	Ligation|nmod|START_ENTITY induces|nsubj|Ligation induces|dobj|polarization polarization|nmod|cells cells|compound|END_ENTITY	Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells .
16406844	0	CD28	90,94	CD4	63,66	CD28	CD4	940	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Ex vivo expansion of dendritic-cell-activated antigen-specific CD4 + T cells with anti-CD3 / CD28 , interleukin-7 , and interleukin-15 : potential for adoptive T cell immunotherapy .
16600196	0	CD28	0,4	CD4	89,92	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|nmod|memory memory|nmod|cells cells|compound|END_ENTITY	CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4 + T cells in vivo .
16828835	0	CD28	52,56	CD4	21,24	CD28	CD4	25660(Tax:10116)	24932(Tax:10116)	Gene	Gene	responsiveness|compound|START_ENTITY develop|dobj|responsiveness develop|nsubj|cells cells|nummod|END_ENTITY	HIV-1 transgenic rat CD4 + T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation .
17038912	0	CD28	15,19	CD4	104,107	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY converted|nsubj|Requirement converted|dobj|Tregs Tregs|nmod|CD25 CD25|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD28	15,19	CD4	76,79	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY converted|nsubj|Requirement converted|dobj|Tregs Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17121217	0	CD28	21,25	CD4	40,43	CD28	CD4	940	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	-LSB- Abnormal changes of CD28 expression on CD4 + T cells in treatment-n ive and highly active antiretroviral therapy-treated HIV/AIDS patients -RSB- .
17144101	0	CD28	24,28	CD4	102,105	CD28	CD4	940	920	Gene	Gene	molecule|compound|START_ENTITY molecule|nmod|END_ENTITY	-LSB- Variable expression of CD28 costimulatory molecule and CTLA4 inhibitory molecule on peripheral blood CD4 + cells in kidney allograft recipients with and without acute graft rejection -RSB- .
17332357	0	CD28	0,4	CD4	118,121	CD28	CD4	940	920	Gene	Gene	costimulation|compound|START_ENTITY overcomes|nsubj|costimulation overcomes|dobj|repression repression|nmod|proliferation proliferation|nmod|+ +|compound|END_ENTITY	CD28 costimulation overcomes transforming_growth_factor-beta-mediated repression of proliferation of redirected human CD4 + and CD8 + T cells in an antitumor cell attack .
17635872	0	CD28	13,17	CD4	93,96	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	costimulatory_molecule|nsubj|START_ENTITY costimulatory_molecule|xcomp|signaling signaling|dobj|requirements requirements|nmod|immunity immunity|compound|END_ENTITY	Differential CD28 and inducible costimulatory_molecule signaling requirements for protective CD4 + T-cell-mediated immunity against genital tract Chlamydia_trachomatis_infection .
17804530	0	CD28	60,64	CD4	55,58	CD28	CD4	940	920	Gene	Gene	cells|compound|START_ENTITY expression|dep|cells expression|nmod|+ +|compound|END_ENTITY	Surface expression of fractalkine_receptor -LRB- CX3CR1 -RRB- on CD4 + / CD28 T cells in RA patients and correlation with atherosclerotic_damage .
18346013	0	CD28	0,4	CD4	23,26	CD28	CD4	940	920	Gene	Gene	downregulation|nummod|START_ENTITY downregulation|nmod|cells cells|compound|END_ENTITY	CD28 downregulation on CD4 + T cells is associated with age of kidney transplant recipient .
18446791	0	CD28	64,68	CD4	30,33	CD28	CD4	940	920	Gene	Gene	cells|nmod|START_ENTITY generates|nsubj|cells T|ccomp|generates T|nsubj|expansion expansion|nmod|END_ENTITY	Selective expansion of memory CD4 -LRB- + -RRB- T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells .
1847724	0	CD28	4,8	CD4	75,78	CD28	CD4	940	920	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|provides provides|nmod|alloactivation alloactivation|nmod|cells cells|compound|END_ENTITY	The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4 + T cells .
18617642	0	CD28	0,4	CD4	24,27	CD28	CD4	940	920	Gene	Gene	down-regulation|nummod|START_ENTITY down-regulation|nmod|cells cells|compound|END_ENTITY	CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipients .
18684917	0	CD28	0,4	CD4	63,66	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|cells cells|compound|END_ENTITY	CD28 controls differentiation of regulatory T cells from naive CD4 T cells .
19394279	0	CD28	99,103	CD4	93,96	CD28	CD4	940	920	Gene	Gene	START_ENTITY|nsubj|DNA DNA|acl:relcl|contribute contribute|nmod|expression expression|nmod|END_ENTITY	Decreased DNA methyltransferase levels contribute to abnormal gene expression in `` senescent '' CD4 -LRB- + -RRB- CD28 -LRB- - -RRB- T cells .
19949106	0	CD28	56,60	CD4	0,3	CD28	CD4	940	920	Gene	Gene	form|nmod|START_ENTITY resist|dobj|form regulatory|ccomp|resist regulatory|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells resist a novel form of CD28 - and Fas-dependent p53-induced T cell apoptosis .
19961728	0	CD28	80,84	CD4	50,53	CD28	CD4	940	920	Gene	Gene	T|compound|START_ENTITY T|dep|Kv1 Kv1|dobj|changes changes|nmod|END_ENTITY	-LSB- Kv1 .3 potassium channel expression changes after CD4 -LRB- + -RRB- and subsets CD28 -LRB- null -RRB- / CD28 -LRB- + -RRB- T cells activation in peripheral blood of patients with acute_coronary_syndrome -RSB- .
20126467	0	CD28	0,4	CD4	36,39	CD28	CD4	940	920	Gene	Gene	down-regulation|nummod|START_ENTITY down-regulation|acl|circulating circulating|dobj|T-cells T-cells|compound|END_ENTITY	CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic_pulmonary_fibrosis .
20880392	0	CD28	78,82	CD4	97,100	CD28	CD4	940	920	Gene	Gene	expression|compound|START_ENTITY differences|nmod|expression explained|nmod|differences explained|nmod|T-cells T-cells|compound|END_ENTITY	Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4 + effector memory T-cells .
21324454	0	CD28	4,8	CD4	0,3	CD28	CD4	940	920	Gene	Gene	lymphocytes|nummod|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD28 null T lymphocytes are expanded in young women with polycystic_ovary_syndrome .
21635686	0	CD28	117,121	CD4	113,116	CD28	CD4	940	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-15 preferentially enhances functional properties and antigen-specific responses of CD4 + CD28 -LRB- null -RRB- compared to CD4 + CD28 + T cells .
21949793	0	CD28	49,53	CD4	81,84	CD28	CD4	940	920	Gene	Gene	functions|compound|START_ENTITY functions|nmod|cells cells|compound|END_ENTITY	Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4 + T cells .
22261542	0	CD28	49,53	CD4	4,7	CD28	CD4	940	920	Gene	Gene	molecule|compound|START_ENTITY expression|nmod|molecule lacking|dobj|expression subset|acl|lacking subset|compound|END_ENTITY	The CD4 + T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple_sclerosis .
22385243	0	CD28	81,85	CD4	14,17	CD28	CD4	940	920	Gene	Gene	engagement|compound|START_ENTITY respond|nmod|engagement respond|nsubj|cells cells|compound|END_ENTITY	Human mucosal CD4 + T cells but not blood CD4 + T cells respond vigorously towards CD28 engagement .
22416257	0	CD28	76,80	CD4	109,112	CD28	CD4	940	920	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|cells cells|compound|END_ENTITY	Granzyme_B - and Fas_ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4 + T cells .
22567259	0	CD28	54,58	CD4	62,65	CD28	CD4	940	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Decreased expression of T-cell costimulatory molecule CD28 on CD4 and CD8 T cells of mexican patients with pulmonary_tuberculosis .
22585421	0	CD28	25,29	CD4	7,10	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	costimulation|compound|START_ENTITY necessary|nsubj|costimulation necessary|nmod|help help|compound|END_ENTITY	Unlike CD4 + T-cell help , CD28 costimulation is necessary for effective primary CD8 + T-cell influenza-specific immunity .
22750548	0	CD28	112,116	CD4	95,98	CD28	CD4	940	920	Gene	Gene	costimulation|compound|START_ENTITY induces|nmod|costimulation induces|dobj|chemokine chemokine|nmod|cells cells|compound|END_ENTITY	poly -LRB- I : C -RRB- costimulation induces a stronger antiviral chemokine and granzyme_B release in human CD4 T cells than CD28 costimulation .
22754764	0	CD28	60,64	CD4	112,115	CD28	CD4	940	920	Gene	Gene	START_ENTITY|acl|induced induced|nmod|T T|compound|END_ENTITY	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
22896637	0	CD28	0,4	CD4	14,17	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expansion expansion|compound|END_ENTITY	CD28 promotes CD4 + T cell clonal expansion during infection independently of its YMNM and PYAP motifs .
23821416	1	CD28	62,66	CD4	56,59	CD28	CD4	940	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Part I : CD4 CD28 lymphocytes and common carotid artery intima-media_thickness .
23821417	1	CD28	72,76	CD4	66,69	CD28	CD4	940	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Part II : CD4 CD28 lymphocytes and carotid artery_atherosclerotic_plaque characteristics .
23859408	0	CD28	95,99	CD4	58,61	CD28	CD4	940	920	Gene	Gene	START_ENTITY|dep|using using|dep|Influence Influence|nmod|method method|nmod|optimization optimization|nmod|expansion expansion|compound|END_ENTITY	Influence of cell isolation method on the optimization of CD4 + T cell expansion using anti-CD3 / CD28 coated beads .
23948413	0	CD28	1,5	CD4	20,23	CD28	CD4	940	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- CD28 expression on CD4 -LRB- + -RRB- ; T cells and its relationship with IFN-y/IL -10 ratio in patients with primary immune_thrombocytopenia -RSB- .
24048955	0	CD28	0,4	CD4	26,29	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|T T|compound|END_ENTITY	CD28 signaling in primary CD4 -LRB- + -RRB- T cells : identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways .
24298980	0	CD28	88,92	CD4	96,99	CD28	CD4	940	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	T cells from chronic bone_infection show reduced proliferation and a high proportion of CD28 CD4 T cells .
24516382	0	CD28	22,26	CD4	140,143	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	deletion|nmod|START_ENTITY impairs|nsubj|deletion impairs|dobj|expulsion expulsion|nmod|responses responses|compound|END_ENTITY	Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis_infection impairs worm expulsion and recall of protective memory CD4 T cell responses .
26155145	0	CD28	20,24	CD4	0,3	CD28	CD4	940	920	Gene	Gene	CD25|appos|START_ENTITY CD25|compound|END_ENTITY	CD4 + CD25 -LRB- high -RRB- , CD8 + CD28 - cells and thyroid autoantibodies in breast_cancer patients .
26613671	0	CD28	5,9	CD4	0,3	CD28	CD4	940	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	CD4 + CD28 Negative Cells : Armed and Dangerous .
7515929	0	CD28	88,92	CD4	32,35	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY Costimulation|appos|ligand Costimulation|nmod|+ +|compound|END_ENTITY	Costimulation of tumor-reactive CD4 + and CD8 + T lymphocytes by B7 , a natural ligand for CD28 , can be used to treat established mouse melanoma .
7522154	0	CD28	109,113	CD4	74,77	CD28	CD4	940	920	Gene	Gene	costimulation|compound|START_ENTITY overcome|nmod|costimulation overcome|nsubjpass|Differences Differences|nmod|cells cells|amod|responsiveness responsiveness|nmod|stimulation stimulation|nmod|T T|compound|END_ENTITY	Differences in responsiveness to CD3 stimulation between naive and memory CD4 + T cells can not be overcome by CD28 costimulation .
7586736	0	CD28	95,99	CD4	49,52	CD28	CD4	940	920	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|Human_immunodeficiency_virus_type_1_infection Human_immunodeficiency_virus_type_1_infection|nmod|cells cells|compound|END_ENTITY	Human_immunodeficiency_virus_type_1_infection of CD4 + T cells down-regulates the expression of CD28 : effect on T cell activation and cytokine production .
7697540	0	CD28	25,29	CD4	74,77	CD28	CD4	940	920	Gene	Gene	levels|nmod|START_ENTITY Alterations|nmod|levels Alterations|parataxis|+ +|dep|lymphocytes lymphocytes|compound|END_ENTITY	Alterations in levels of CD28 - / CD8 + suppressor cell precursor and CD45RO + / CD4 + memory T lymphocytes in the peripheral blood of multiple_sclerosis patients .
7822814	0	CD28	74,78	CD4	38,41	CD28	CD4	12487(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY +|nmod|ligation +|nsubj|transduction transduction|nmod|+ +|compound|END_ENTITY	Distinct signal transduction in mouse CD4 + and CD8 + splenic_T cells after CD28 receptor ligation .
7875222	0	CD28	0,4	CD4	61,64	CD28	CD4	940	920	Gene	Gene	activation|compound|START_ENTITY promotes|nsubj|activation promotes|nmod|cells cells|compound|END_ENTITY	CD28 activation promotes Th2 subset differentiation by human CD4 + cells .
7906302	0	CD28	18,22	CD4	42,45	CD28	CD4	940	920	Gene	Gene	antigen|compound|START_ENTITY antigen|nmod|+ +|compound|END_ENTITY	Downregulation of CD28 surface antigen on CD4 + and CD8 + T lymphocytes during HIV-1_infection .
8294878	0	CD28	135,139	CD4	22,25	CD28	CD4	940	920	Gene	Gene	provided|nmod|START_ENTITY signal|acl:relcl|provided requires|dobj|signal requires|nsubj|selection selection|nmod|thymocytes thymocytes|compound|END_ENTITY	Negative selection of CD4 + CD8 + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 .
8621791	0	CD28	10,14	CD4	0,3	CD28	CD4	940	920	Gene	Gene	CD7|dep|START_ENTITY CD7|compound|END_ENTITY	CD4 + CD7 - CD28 - T cells are expanded in rheumatoid_arthritis and are characterized by autoreactivity .
8943568	0	CD28	66,70	CD4	0,3	CD28	CD4	940	920	Gene	Gene	ligation|compound|START_ENTITY recall|nmod|ligation respond|xcomp|recall respond|nsubj|cells cells|compound|END_ENTITY	CD4 + CD45RA + T cells from adults respond to recall antigens after CD28 ligation .
9382889	0	CD28	130,134	CD4	48,51	CD28	CD4	940	920	Gene	Gene	costimulation|compound|START_ENTITY requirement|nmod|costimulation differing|nmod|requirement mechanisms|acl|differing death|nmod|mechanisms death|nmod|thymocytes thymocytes|compound|END_ENTITY	T cell receptor -LRB- TCR -RRB- - induced death of immature CD4 + CD8 + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation : implications for negative selection in the thymus .
9550389	0	CD28	11,15	CD4	60,63	CD28	CD4	940	920	Gene	Gene	Effects|nmod|START_ENTITY costimulation|nsubj|Effects costimulation|nmod|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Effects of CD28 costimulation on long-term proliferation of CD4 + T cells in the absence of exogenous feeder cells .
9820490	0	CD28	80,84	CD4	30,33	CD28	CD4	940	920	Gene	Gene	+|nmod|START_ENTITY +|nsubj|suppression suppression|nmod|END_ENTITY	Specific suppression of human CD4 + Th cell responses to pig MHC antigens by CD8 + CD28 - regulatory T cells .
9834109	0	CD28	24,28	CD4	64,67	CD28	CD4	940	920	Gene	Gene	effects|nmod|START_ENTITY costimulation|nsubj|effects costimulation|nmod|cells cells|compound|END_ENTITY	Differential effects of CD28 costimulation on HIV production by CD4 + cells .
10458748	0	CD28	38,42	CD40	9,13	CD28	CD40	940	958	Gene	Gene	interactions|nummod|START_ENTITY END_ENTITY|dep|interactions	Blocking CD40 - CD154 and CD80/CD86 - CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production .
11160303	0	CD28	20,24	CD40_ligand	49,60	CD28	CD40 ligand	940	959	Gene	Gene	element|compound|START_ENTITY Identification|nmod|element Identification|nmod|promoter promoter|amod|END_ENTITY	Identification of a CD28 response element in the CD40_ligand promoter .
15067037	0	CD28	57,61	CD40_ligand	18,29	CD28	CD40 ligand	940	959	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	The modulation of CD40_ligand signaling by transmembrane CD28 splice variant in human T cells .
7790813	0	CD28	79,83	CD43	0,4	CD28	CD43	12487(Tax:10090)	20737(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	CD43 is a murine T cell costimulatory receptor that functions independently of CD28 .
23747721	0	CD28	85,89	CD45RA-CD27	71,82	CD28	CD45RA-CD27	940	939	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD45RA-Foxp3 -LRB- high -RRB- activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28 + central memory subset are decreased in peripheral blood from patients with rheumatoid_arthritis .
9075840	0	CD28	83,87	CD57	76,80	CD28	CD57	940	27087	Gene	Gene	cells|nummod|START_ENTITY +|appos|cells +|compound|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9766502	0	CD28	6,10	CD57	0,4	CD28	CD57	940	27087	Gene	Gene	cells|dep|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD57 + / CD28 - T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile , ex vivo cytolytic activity and enhanced tendency to apoptosis .
10069421	0	CD28	83,87	CD8	25,28	CD28	CD8	940	925	Gene	Gene	persistence|nmod|START_ENTITY implications|nmod|persistence Differentiation|dep|implications Differentiation|nmod|cells cells|compound|END_ENTITY	Differentiation of human CD8 T cells : implications for in vivo persistence of CD8 + CD28 - cytotoxic effector clones .
10193418	0	CD28	14,18	CD8	31,34	CD28	CD8	940	925	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|T T|compound|END_ENTITY	Expression of CD28 and CD38 by CD8 + T lymphocytes in HIV-1_infection correlates with markers of disease severity and changes towards normalization under treatment .
10331493	0	CD28	135,139	CD8	52,55	CD28	CD8	940	925	Gene	Gene	number|nmod|START_ENTITY accounting|nmod|number Generation|dep|accounting Generation|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD28	14,18	CD8	131,134	CD28	CD8	940	925	Gene	Gene	Generation|nmod|START_ENTITY Generation|dep|accounting accounting|nmod|number number|nmod|CD28 CD28|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD28	14,18	CD8	52,55	CD28	CD8	940	925	Gene	Gene	Generation|nmod|START_ENTITY Generation|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD28	56,60	CD8	131,134	CD28	CD8	940	925	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Generation|dep|cells Generation|dep|accounting accounting|nmod|number number|nmod|CD28 CD28|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD28	56,60	CD8	52,55	CD28	CD8	940	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10421790	0	CD28	57,61	CD8	17,20	CD28	CD8	940	925	Gene	Gene	progeny|compound|START_ENTITY give|nmod|progeny T|ccomp|give T|nsubj|CD28 CD28|compound|END_ENTITY	Peripheral human CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T lymphocytes give rise to CD28 -LRB- - -RRB- progeny , but IL-4 prevents loss of CD28 expression .
10583606	0	CD28	96,100	CD8	102,105	CD28	CD8	940	925	Gene	Gene	lymphocytes|nmod|START_ENTITY population|dep|lymphocytes population|compound|END_ENTITY	Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57 + CD28 - CD8 + T-cell population .
10882412	0	CD28	8,12	CD8	27,30	CD28	CD8	940	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Loss of CD28 expression on CD8 -LRB- + -RRB- T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN , and increases susceptibility to activation-induced apoptosis .
10964536	0	CD28	68,72	CD8	46,49	CD28	CD8	940	925	Gene	Gene	costimulation|compound|START_ENTITY T-cells|nmod|costimulation T-cells|compound|END_ENTITY	Response differences between human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T-cells during CD28 costimulation : implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging .
11145666	0	CD28	32,36	CD8	28,31	CD28	CD8	940	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD11b expression identifies CD8 + CD28 + T lymphocytes with phenotype and function of both naive/memory and effector cells .
11887352	0	CD28	33,37	CD8	66,69	CD28	CD8	940	925	Gene	Gene	antigen|compound|START_ENTITY antigen|nmod|T T|compound|END_ENTITY	-LSB- Expression of the costimulatory CD28 antigen on peripheral blood CD8 + T lymphocytes in patients with chronic hepatitis_C -RSB- .
11985525	0	CD28	40,44	CD8	45,48	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A reduction in the number of peripheral CD28 + CD8 + T cells in the acute phase of influenza .
12390853	0	CD28	30,34	CD8	13,16	CD28	CD8	940	925	Gene	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	-LSB- Analysis of CD8 -LRB- + -RRB- and CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- cell subsets in patients with hepatocellular_carcinoma -RSB- .
12391201	0	CD28	0,4	CD8	102,105	CD28	CD8	12487(Tax:10090)	925	Gene	Gene	cells|nsubj|START_ENTITY cells|amod|critical critical|nmod|cross-priming cross-priming|nmod|T T|compound|END_ENTITY	CD28 , TNF receptor , and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8 + T cells .
12392852	0	CD28	56,60	CD8	71,74	CD28	CD8	940	925	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|CD28 CD28|compound|END_ENTITY	Proliferative_arrest and cell cycle regulation in CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- versus CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T cells .
12392852	0	CD28	77,81	CD8	50,53	CD28	CD8	940	925	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|CD28 CD28|compound|END_ENTITY	Proliferative_arrest and cell cycle regulation in CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- versus CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T cells .
12519392	0	CD28	132,136	CD8	65,68	CD28	CD8	940	925	Gene	Gene	flow-assisted|nmod|START_ENTITY recognized|nmod|flow-assisted recognized|nmod|cells cells|compound|END_ENTITY	Definition of the HLA-A2 restricted peptides recognized by human CD8 + effector T cells by flow-assisted sorting of the CD8 + CD45RA + CD28 - T cell subpopulation .
12626553	0	CD28	0,4	CD8	34,37	CD28	CD8	940	925	Gene	Gene	signal|compound|START_ENTITY enhances|nsubj|signal enhances|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	CD28 signal enhances apoptosis of CD8 T cells after strong TCR ligation .
12882659	0	CD28	58,62	CD8	14,17	CD28	CD8	940	925	Gene	Gene	suppressive|nmod|START_ENTITY suppressive|nsubj|Production Production|nmod|nonlytic nonlytic|compound|END_ENTITY	Production of CD8 + T cell nonlytic suppressive factors by CD28 , CD38 , and HLA-DR subpopulations .
12963692	0	CD28	15,19	CD8	40,43	CD28	CD8	940	925	Gene	Gene	expression|nummod|START_ENTITY Restoration|nmod|expression Restoration|dep|effector effector|compound|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
12963692	0	CD28	34,38	CD8	40,43	CD28	CD8	940	925	Gene	Gene	expression|nmod|START_ENTITY Restoration|nmod|expression Restoration|dep|effector effector|compound|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
14969769	0	CD28	69,73	CD8	20,23	CD28	CD8	940	925	Gene	Gene	originate|nmod|START_ENTITY lymphocytes|dep|originate lymphocytes|nsubj|suppressor suppressor|compound|END_ENTITY	Nonantigen specific CD8 + T suppressor lymphocytes originate from CD8 + CD28 - T cells and inhibit both T-cell proliferation and CTL function .
15096190	0	CD28	122,126	CD8	7,10	CD28	CD8	12487(Tax:10090)	925	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|expansion expansion|compound|END_ENTITY	Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L -LRB- 4-1BBL -RRB- is superior to CD28 , and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo .
15473875	0	CD28	51,55	CD8	46,49	CD28	CD8	940	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Growth_hormone -LRB- GH -RRB- - induced reconstitution of CD8 + CD28 + T lymphocytes in a rare case of severe lymphopenia associated with Juvenile_Haemochromatosis and Turner 's _ syndrome .
15719742	0	CD28	34,38	CD8	22,25	CD28	CD8	940	925	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Relationship between CD8 + T-cell CD28 expression and TCM differentiation type in patients with chronic_aplastic_anemia -RSB- .
16002671	0	CD28	15,19	CD8	62,65	CD28	CD8	940	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-21 sustains CD28 expression on IL-15-activated human naive CD8 + T cells .
1676547	0	CD28	112,116	CD8	25,28	CD28	CD8	940	925	Gene	Gene	activation|compound|START_ENTITY mediated|nmod|activation transcription|acl|mediated evidence|nmod|transcription Activation|dep|evidence Activation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
1676547	0	CD28	48,52	CD8	25,28	CD28	CD8	940	925	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
17114476	0	CD28	7,11	CD8	42,45	CD28	CD8	940	925	Gene	Gene	costimulation|compound|START_ENTITY required|nsubjpass|costimulation required|nmod|resistance resistance|compound|END_ENTITY	Direct CD28 costimulation is required for CD8 + T cell-mediated resistance to an acute_viral_disease in a natural host .
17173839	0	CD28	50,54	CD8	46,49	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Functional and phenotypic characterization of CD8 + CD28 + and CD28 - T cells in atopic individuals sensitized to Dermatophagoides_pteronyssinus .
17878391	0	CD28	21,25	CD8	55,58	CD28	CD8	940	925	Gene	Gene	START_ENTITY|advcl|generating generating|dobj|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	4-1BB is superior to CD28 costimulation for generating CD8 + cytotoxic lymphocytes for adoptive immunotherapy .
17982038	0	CD28	28,32	CD8	7,10	CD28	CD8	940	925	Gene	Gene	costimulation|compound|START_ENTITY require|dobj|costimulation require|nsubj|cells cells|compound|END_ENTITY	Memory CD8 + T cells require CD28 costimulation .
18162511	0	CD28	14,18	CD8	33,36	CD28	CD8	940	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Regulation of CD28 expression on CD8 + T cells by CTLA-4 .
18563290	0	CD28	30,34	CD8	26,29	CD28	CD8	940	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Decrease in CD4 + CD25 + and CD8 + CD28 + T cells in interstitial_pneumonitis associated with rheumatic_disease .
18570590	0	CD28	42,46	CD8	99,102	CD28	CD8	940	925	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression prevents|dobj|loss prevents|nmod|maturation maturation|nmod|cells cells|dep|ve ve|dobj|+ +|compound|END_ENTITY	HIV-1 matrix protein p17 prevents loss of CD28 expression during IL-2-induced maturation of na ve CD8 -LRB- + -RRB- T cells .
18751903	0	CD28	112,116	CD8	108,111	CD28	CD8	940	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Microarray analysis reveals similarity between CD8 + CD28 - T cells from young and elderly persons , but not of CD8 + CD28 + T cells .
19797296	0	CD28	80,84	CD8	86,89	CD28	CD8	940	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28 + CD8 memory T cells throughout the adult age span .
20030671	0	CD28	97,101	CD8	93,96	CD28	CD8	940	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	T-cell activation profiles in different granulomatous interstitial_lung_diseases -- a role for CD8 + CD28 -LRB- null -RRB- cells ?
20721608	0	CD28	10,14	CD8	86,89	CD28	CD8	940	925	Gene	Gene	delays|compound|START_ENTITY delays|dep|features features|nmod|senescence senescence|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes .
21493800	0	CD28	135,139	CD8	112,115	CD28	CD8	940	925	Gene	Gene	Priming|nsubj|START_ENTITY Priming|dep|enhances enhances|dobj|generation generation|nmod|cells cells|compound|END_ENTITY	Priming CD8 + T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8 + T cells retaining CD28 .
21493800	0	CD28	135,139	CD8	8,11	CD28	CD8	940	925	Gene	Gene	Priming|nsubj|START_ENTITY Priming|dobj|cells cells|nummod|END_ENTITY	Priming CD8 + T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8 + T cells retaining CD28 .
22503210	0	CD28	91,95	CD8	40,43	CD28	CD8	940	925	Gene	Gene	receptor|nummod|START_ENTITY co-stimulates|dep|receptor co-stimulates|xcomp|cells cells|nsubj|END_ENTITY	Tumor PD-L1 co-stimulates primary human CD8 -LRB- + -RRB- cytotoxic T cells modified to express a PD1 : CD28 chimeric receptor .
22851040	0	CD28	16,20	CD8	11,14	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	0	CD28	16,20	CD8	24,27	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY Balance|nmod|+ CD28|dep|Balance CD28|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	0	CD28	29,33	CD8	11,14	CD28	CD8	940	925	Gene	Gene	START_ENTITY|dep|Balance Balance|nmod|+ +|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	11	CD28	1627,1631	CD8	1622,1625	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CONCLUSIONS : The balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes plays a vital role in UC , while the balance tilt towards CD8 + CD28 + T lymphocytes is beneficial for patients with UC .
23711708	0	CD28	109,113	CD8	104,107	CD28	CD8	940	925	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8 + CD28 + T lymphocyte responses .
23786396	0	CD28	14,18	CD8	10,13	CD28	CD8	940	925	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Defective CD8 + CD28 + regulatory T cell suppressor function in rheumatoid_arthritis is restored by tumour necrosis factor inhibitor therapy .
24152837	0	CD28	54,58	CD8	81,84	CD28	CD8	940	925	Gene	Gene	activation|compound|START_ENTITY TGF-beta|nmod|activation TGF-beta|nmod|CD28 CD28|compound|END_ENTITY	The effects of interleukin-10 or TGF-beta on anti-CD3 / CD28 induced activation of CD8 + CD28 - and CD8 + CD28 + T cells in allergic_asthma .
24152837	0	CD28	99,103	CD8	95,98	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of interleukin-10 or TGF-beta on anti-CD3 / CD28 induced activation of CD8 + CD28 - and CD8 + CD28 + T cells in allergic_asthma .
24432600	0	CD28	29,33	CD8	25,28	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The value of changes in CD8 + CD28 + and CD4 + CD28 + cells in patients with HIV_infection concurrent with tuberculosis during treatment -RSB- .
24585893	0	CD28	19,23	CD8	25,28	CD28	CD8	940	925	Gene	Gene	proportions|nmod|START_ENTITY proportions|dep|cells cells|nummod|END_ENTITY	Low proportions of CD28 - CD8 + T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV_infection .
24842641	0	CD28	27,31	CD8	42,45	CD28	CD8	940	925	Gene	Gene	proliferation|amod|START_ENTITY proliferation|compound|END_ENTITY	IL-15 induces alloreactive CD28 -LRB- - -RRB- memory CD8 T cell proliferation and CTLA4-Ig resistant memory CD8 T cell activation .
25013781	0	CD28	34,38	CD8	54,57	CD28	CD8	940	925	Gene	Gene	START_ENTITY|acl|circulating circulating|dobj|cells cells|nummod|END_ENTITY	Changes of costimulatory molecule CD28 on circulating CD8 + T cells correlate with disease pathogenesis of chronic hepatitis_B .
25241914	0	CD28	0,4	CD8	8,11	CD28	CD8	940	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD28 CD8 T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes .
26277688	0	CD28	80,84	CD8	41,44	CD28	CD8	940	925	Gene	Gene	identified|nmod|START_ENTITY identified|nsubj|subpopulations subpopulations|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Aging-associated subpopulations of human CD8 + T-lymphocytes identified by their CD28 and CD57 phenotypes .
7539725	0	CD28	94,98	CD8	118,121	CD28	CD8	940	925	Gene	Gene	down-regulation|nummod|START_ENTITY down-regulation|nmod|cells cells|compound|END_ENTITY	Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8 + T cells from HIV-infected subjects .
7697540	0	CD28	25,29	CD8	31,34	CD28	CD8	940	925	Gene	Gene	levels|nmod|START_ENTITY Alterations|nmod|levels Alterations|parataxis|+ +|compound|END_ENTITY	Alterations in levels of CD28 - / CD8 + suppressor cell precursor and CD45RO + / CD4 + memory T lymphocytes in the peripheral blood of multiple_sclerosis patients .
7973455	0	CD28	14,18	CD8	22,25	CD28	CD8	940	925	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Expression of CD28 on CD8 + and CD4 + lymphocytes during HIV_infection .
8294878	0	CD28	135,139	CD8	26,29	CD28	CD8	940	925	Gene	Gene	provided|nmod|START_ENTITY signal|acl:relcl|provided requires|dobj|signal requires|nsubj|selection selection|nmod|thymocytes thymocytes|compound|END_ENTITY	Negative selection of CD4 + CD8 + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 .
8621891	0	CD28	115,119	CD8	120,123	CD28	CD8	940	925	Gene	Gene	counterparts|compound|START_ENTITY counterparts|compound|END_ENTITY	Shortened_telomeres in clonally expanded CD28-CD8 + T cells imply a replicative history that is distinct from their CD28 + CD8 + counterparts .
8693288	0	CD28	65,69	CD8	41,44	CD28	CD8	940	925	Gene	Gene	costimulation|compound|START_ENTITY role|nmod|costimulation activation|dep|role activation|nmod|cells cells|compound|END_ENTITY	T helper-independent activation of human CD8 + cells : the role of CD28 costimulation .
8834463	5	CD28	867,871	CD8	863,866	CD28	CD8	940	925	Gene	Gene	ratio|compound|START_ENTITY ratio|nummod|+ +|compound|END_ENTITY	The strong correlation between the CD4 + / CD8 + ratio and the CD8 + CD28 + / CD8 + CD28 - ratio suggests either a role for CD4 + cells in controlling the CD28 + phenotype or a role for CD8 + CD28 - cells in the decline of CD4 + lymphocytes .
8881750	0	CD28	134,138	CD8	33,36	CD28	CD8	940	925	Gene	Gene	molecules|dep|START_ENTITY maintenance|amod|molecules loss|nmod|maintenance Factors|dep|loss Factors|acl:relcl|influence influence|dobj|apoptosis apoptosis|compound|END_ENTITY	Factors that influence activated CD8 + T-cell apoptosis in patients with acute_herpesvirus_infections : loss of costimulatory molecules CD28 , CD5 and CD6 but relative maintenance of Bax and Bcl-X expression .
9029089	0	CD28	14,18	CD8	42,45	CD28	CD8	940	925	Gene	Gene	Regulation|nmod|START_ENTITY costimulation|nsubj|Regulation costimulation|nmod|cells cells|compound|END_ENTITY	Regulation of CD28 costimulation in human CD8 + T cells .
9067514	0	CD28	54,58	CD8	0,3	CD28	CD8	940	925	Gene	Gene	activation|amod|START_ENTITY hyporesponsive|nmod|activation hyporesponsive|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD8 + cells and not CD4 + T cells are hyporesponsive to CD28 - and CD40L-mediated activation in HIV-infected subjects .
9067531	0	CD28	87,91	CD8	17,20	CD28	CD8	940	925	Gene	Gene	expansions|nmod|START_ENTITY Anomalies|dep|expansions Anomalies|nmod|pool pool|compound|END_ENTITY	Anomalies of the CD8 + T cell pool in haemochromatosis : HLA-A3-linked expansions of CD8 + CD28 - T cells .
9075840	0	CD28	122,126	CD8	145,148	CD28	CD8	940	925	Gene	Gene	CD57|nummod|START_ENTITY expansion|nmod|CD57 cells|nmod|expansion +|appos|cells mobilization|nmod|+ response|dep|mobilization response|dep|cells cells|nmod|compartment compartment|compound|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9075840	0	CD28	83,87	CD8	145,148	CD28	CD8	940	925	Gene	Gene	cells|nummod|START_ENTITY +|appos|cells mobilization|nmod|+ response|dep|mobilization response|dep|cells cells|nmod|compartment compartment|compound|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9366442	0	CD28	0,4	CD8	29,32	CD28	CD8	940	925	Gene	Gene	costimulation|compound|START_ENTITY increases|nsubj|costimulation increases|dobj|suppression suppression|compound|END_ENTITY	CD28 costimulation increases CD8 + cell suppression of HIV replication .
9382889	0	CD28	130,134	CD8	52,55	CD28	CD8	940	925	Gene	Gene	costimulation|compound|START_ENTITY requirement|nmod|costimulation differing|nmod|requirement mechanisms|acl|differing death|nmod|mechanisms death|nmod|thymocytes thymocytes|compound|END_ENTITY	T cell receptor -LRB- TCR -RRB- - induced death of immature CD4 + CD8 + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation : implications for negative selection in the thymus .
9421475	0	CD28	26,30	CD8	22,25	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Contribution of CD4 + , CD8 + CD28 + , and CD8 + CD28 - T cells to CD3 + lymphocyte homeostasis during the natural course of HIV-1_infection .
9472663	0	CD28	183,187	CD8	18,21	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY interferon-gamma|nmod|+ production|nmod|interferon-gamma abnormalities|nmod|production defect|dep|abnormalities defect|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9472663	0	CD28	183,187	CD8	228,231	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY interferon-gamma|nmod|+ production|nmod|interferon-gamma abnormalities|nmod|production defect|dep|abnormalities defect|dep|+ +|compound|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9603481	0	CD28	59,63	CD8	55,58	CD28	CD8	940	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Demonstration of identical expanded clones within both CD8 + CD28 + and CD8 + CD28 - T cell subsets in HIV_type_1-infected individuals .
10502560	0	CD28	0,4	CD80	30,34	CD28	CD80	12487(Tax:10090)	12519(Tax:10090)	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	CD28 interactions with either CD80 or CD86 are sufficient to induce allergic_airway_inflammation in mice .
10600000	0	CD28	54,58	CD80	42,46	CD28	CD80	940	941	Gene	Gene	CD86|nummod|START_ENTITY CD86|nummod|END_ENTITY	Expression of the costimulator molecules , CD80 , CD86 , CD28 , and CD152 on lymphocytes from neonates and young children .
14975355	0	CD28	51,55	CD80	39,43	CD28	CD80	940	941	Gene	Gene	CD152|compound|START_ENTITY END_ENTITY|dep|CD152	Expression of costimulatory molecules -LRB- CD80 , CD86 , CD28 , CD152 -RRB- , accessory molecules -LRB- TCR alphabeta , TCR gammadelta -RRB- and T cell lineage molecules -LRB- CD4 + , CD8 + -RRB- in PBMC of leprosy patients using Mycobacterium_leprae antigen -LRB- MLCWA -RRB- with murabutide and T cell peptide of Trat protein .
15467723	0	CD28	0,4	CD80	62,66	CD28	CD80	12487(Tax:10090)	12519(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|END_ENTITY	CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86 .
16339518	0	CD28	49,53	CD80	0,4	CD28	CD80	12487(Tax:10090)	12519(Tax:10090)	Gene	Gene	CTLA-4|compound|START_ENTITY localization|nmod|CTLA-4 controls|dobj|localization controls|nsubj|domain domain|nummod|END_ENTITY	CD80 cytoplasmic domain controls localization of CD28 , CTLA-4 , and protein kinase Ctheta in the immunological synapse .
16703581	0	CD28	41,45	CD80	47,51	CD28	CD80	940	941	Gene	Gene	CTLA-4|nummod|START_ENTITY CTLA-4|nummod|END_ENTITY	Plasma concentrations of soluble CTLA-4 , CD28 , CD80 and CD86 costimulatory molecules reflect disease severity of acute_asthma in children .
16708397	0	CD28	15,19	CD80	88,92	CD28	CD80	940	941	Gene	Gene	Integration|nmod|START_ENTITY function|nsubj|Integration function|nmod|END_ENTITY	Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86 .
17953528	0	CD28	95,99	CD80	81,85	CD28	CD80	940	941	Gene	Gene	binds|nmod|START_ENTITY binds|compound|END_ENTITY	Human Soluble CD80 is generated by alternative splicing , and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation .
7534620	0	CD28	87,91	CD80	12,16	CD28	CD80	940	941	Gene	Gene	receptors|compound|START_ENTITY bind|nmod|receptors bind|nsubj|B7-1 B7-1|appos|END_ENTITY	Human B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors .
7544393	0	CD28	101,105	CD80	46,50	CD28	CD80	940	941	Gene	Gene	implicated|nmod|START_ENTITY implicated|nsubj|Identification Identification|nmod|residues residues|nmod|domain domain|nmod|END_ENTITY	Identification of residues in the V domain of CD80 -LRB- B7-1 -RRB- implicated in functional interactions with CD28 and CTLA4 .
7577797	0	CD28	0,4	CD80	13,17	CD28	CD80	940	941	Gene	Gene	ligands|nsubj|START_ENTITY ligands|ccomp|induce induce|nsubj|END_ENTITY	CD28 ligands CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- induce long-term autocrine growth of CD4 + T cells and induce similar patterns of cytokine secretion in vitro .
8609386	0	CD28	35,39	CD80	16,20	CD28	CD80	940	941	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of CD80 and CD86 with CD28 and CTLA4 .
8683128	0	CD28	39,43	CD80	71,75	CD28	CD80	940	941	Gene	Gene	interaction|nmod|START_ENTITY site|nmod|interaction Analysis|nmod|site Analysis|nmod|END_ENTITY	Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function .
8921441	0	CD28	0,4	CD80	118,122	CD28	CD80	940	941	Gene	Gene	regimes|nummod|START_ENTITY differ|nsubj|regimes differ|xcomp|3-kinase 3-kinase|dep|co-signals co-signals|acl|induced induced|nmod|END_ENTITY	CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase : common co-signals induced by CD80 and CD86 .
9053440	0	CD28	23,27	CD80	0,4	CD28	CD80	940	941	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	CD80 -LRB- B7-1 -RRB- binds both CD28 and CTLA-4 with a low affinity and very fast kinetics .
9915850	0	CD28	92,96	CD80	0,4	CD28	CD80	940	941	Gene	Gene	phosphorylation|nmod|START_ENTITY induce|dobj|phosphorylation ability|acl|induce equivalent|nmod|ability equivalent|nsubj|END_ENTITY	CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28 .
11972629	2	CD28	454,458	CD95	448,452	CD28	CD95	940	355	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	We aimed to elucidate the reconstitution of CD8 + T cells by separate analysis of putative na ve CD95 - CD28 + , memory CD95 + CD28 + and CD28 - T cell compartments after acute maximal depletion by high-dose_chemotherapy -LRB- HD-ChT -RRB- in women with high-risk breast_cancer .
9708185	0	CD28	19,23	CD95	33,37	CD28	CD95	940	355	Gene	Gene	START_ENTITY|nmod|Fas Fas|appos|END_ENTITY	Down-regulation of CD28 via Fas -LRB- CD95 -RRB- : influence of CD28 on T-cell apoptosis .
9708185	0	CD28	53,57	CD95	33,37	CD28	CD95	940	355	Gene	Gene	influence|nmod|START_ENTITY Down-regulation|dep|influence Down-regulation|nmod|CD28 CD28|nmod|Fas Fas|appos|END_ENTITY	Down-regulation of CD28 via Fas -LRB- CD95 -RRB- : influence of CD28 on T-cell apoptosis .
10713366	0	CD28	90,94	CTLA-4	37,43	CD28	CTLA-4	940	1493	Gene	Gene	pathway|compound|START_ENTITY hyper-reactivity|nmod|pathway T|dobj|hyper-reactivity leads|xcomp|T leads|nsubj|expansion expansion|nmod|gene gene|compound|END_ENTITY	Dinucleotide repeat expansion in the CTLA-4 gene leads to T cell hyper-reactivity via the CD28 pathway in myasthenia_gravis .
12525576	0	CD28	36,40	CTLA-4	66,72	CD28	CTLA-4	940	1493	Gene	Gene	segment|nmod|START_ENTITY sufficient|nsubj|segment sufficient|xcomp|convert convert|dobj|END_ENTITY	Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor .
12956876	0	CD28	30,34	CTLA-4	84,90	CD28	CTLA-4	940	1493	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization of CD28 and cytotoxic_T-lymphocyte-associated_antigen_4 -LRB- CTLA-4 -RRB- of woodchuck -LRB- Marmota monax -RRB- .
16903911	0	CD28	12,16	CTLA-4	55,61	CD28	CTLA-4	940	1493	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of CD28 and cytotoxic_T-lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- in regulatory T-cell biology .
17702861	0	CD28	72,76	CTLA-4	35,41	CD28	CTLA-4	12487(Tax:10090)	12477(Tax:10090)	Gene	Gene	motif|compound|START_ENTITY depends|nmod|motif depends|nsubj|Induction Induction|nmod|mice mice|amod|autoimmune_disease autoimmune_disease|nmod|END_ENTITY	Induction of autoimmune_disease in CTLA-4 - / - mice depends on a specific CD28 motif that is required for in vivo costimulation .
18162511	0	CD28	14,18	CTLA-4	49,55	CD28	CTLA-4	940	1493	Gene	Gene	expression|nummod|START_ENTITY Regulation|nmod|expression T|nsubj|Regulation T|nmod|END_ENTITY	Regulation of CD28 expression on CD8 + T cells by CTLA-4 .
23045162	0	CD28	21,25	CTLA-4	14,20	CD28	CTLA-4	940	1493	Gene	Gene	axis|nummod|START_ENTITY Impact|dep|axis Impact|nmod|END_ENTITY	Impact of the CTLA-4 / CD28 axis on the processes of joint inflammation in rheumatoid_arthritis .
25548162	0	CD28	87,91	CTLA-4	0,6	CD28	CTLA-4	12487(Tax:10090)	12477(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY strength|nmod|engagement regulating|dobj|strength controls|dep|regulating controls|dep|END_ENTITY	CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement .
9228944	0	CD28	92,96	CTLA-4	28,34	CD28	CTLA-4	940	1493	Gene	Gene	conserved|nmod|START_ENTITY conserved|nsubj|structure structure|nmod|END_ENTITY	Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28 .
9780158	0	CD28	83,87	CTLA-4	76,82	CD28	CTLA-4	100769830	100765782	Gene	Gene	CD80|compound|START_ENTITY CD80|compound|END_ENTITY	Positive and negative regulation of human T cell activation mediated by the CTLA-4 / CD28 ligand CD80 .
9653096	0	CD28	164,168	CTLA4	128,133	CD28	CTLA4	12487(Tax:10090)	12477(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA4 -RRB- blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice : CTLA4 can function independently of CD28 .
14697337	0	CD28	20,24	EphA3	0,5	CD28	EphA3	940	2042	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion .
7568038	0	CD28	27,31	GRB-2	111,116	CD28	GRB-2	940	2885	Gene	Gene	factor|compound|START_ENTITY factor|dep|END_ENTITY	p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase , growth factor receptor-bound protein GRB-2 , and T_cell-specific_protein-tyrosine_kinase ITK : implications for T-cell costimulation .
24475931	0	CD28	54,58	Grb2	106,110	CD28	Grb2	940	2885	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2 , Gads and p85 PI3K .
11046032	0	CD28	72,76	ICOS	40,44	CD28	ICOS	12487(Tax:10090)	54167(Tax:10090)	Gene	Gene	costimulation|compound|START_ENTITY enhanced|nmod|costimulation enhanced|nsubjpass|expression expression|appos|END_ENTITY	Mouse inducible_costimulatory molecule -LRB- ICOS -RRB- expression is enhanced by CD28 costimulation and regulates differentiation of CD4 + T cells .
17013990	0	CD28	21,25	ICOS	0,4	CD28	ICOS	940	29851	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	ICOS cooperates with CD28 , IL-2 , and IFN-gamma and modulates activation of human na ve CD4 + T cells .
26098894	0	CD28	64,68	ICOS	104,108	CD28	ICOS	12487(Tax:10090)	54167(Tax:10090)	Gene	Gene	Blockade|compound|START_ENTITY Responses|nmod|Blockade Inhibition|nmod|Responses Independent|nsubj|Inhibition Independent|nmod|Expression Expression|compound|END_ENTITY	Inhibition of Donor-Reactive CD8 + T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression .
10898505	0	CD28	60,64	IL-10	0,5	CD28	IL-10	940	3586	Gene	Gene	co-stimulation|compound|START_ENTITY altering|dobj|co-stimulation acts|advcl|altering acts|nsubj|END_ENTITY	IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway .
10973911	0	CD28	91,95	IL-10	44,49	CD28	IL-10	940	3586	Gene	Gene	phosphorylation|compound|START_ENTITY basis|dep|phosphorylation basis|nmod|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
10973911	0	CD28	91,95	IL-10	67,72	CD28	IL-10	940	3586	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
17531298	0	CD28	15,19	IL-10	0,5	CD28	IL-10	12487(Tax:10090)	16153(Tax:10090)	Gene	Gene	costimulations|compound|START_ENTITY inhibits|dobj|costimulations inhibits|nsubj|END_ENTITY	IL-10 inhibits CD28 and ICOS costimulations of T cells via src_homology_2_domain-containing_protein_tyrosine_phosphatase_1 .
22754764	0	CD28	60,64	IL-10	82,87	CD28	IL-10	940	3586	Gene	Gene	START_ENTITY|acl|induced induced|dobj|secretion secretion|compound|END_ENTITY	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
25382658	0	CD28	119,123	IL-10	78,83	CD28	IL-10	12487(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY convert|dobj|cells convert|iobj|cells cells|nmod|END_ENTITY	Immature dendritic cells convert anergic nonregulatory T cells into Foxp3 -LRB- - -RRB- IL-10 -LRB- + -RRB- regulatory T cells by engaging CD28 and CTLA-4 .
9058822	0	CD28	0,4	IL-10	80,85	CD28	IL-10	12487(Tax:10090)	16153(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY prevents|nsubj|ligation prevents|advcl|inducing inducing|dobj|expression expression|compound|END_ENTITY	CD28 ligation prevents bacterial toxin-induced septic_shock in mice by inducing IL-10 expression .
21635686	0	CD28	117,121	IL-15	0,5	CD28	IL-15	940	3600	Gene	Gene	cells|compound|START_ENTITY enhances|advcl|cells enhances|nsubj|END_ENTITY	IL-15 preferentially enhances functional properties and antigen-specific responses of CD4 + CD28 -LRB- null -RRB- compared to CD4 + CD28 + T cells .
23711708	0	CD28	109,113	IL-15	41,46	CD28	IL-15	940	3600	Gene	Gene	responses|compound|START_ENTITY induce|dobj|responses induce|nsubj|cells cells|nmod|END_ENTITY	Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8 + CD28 + T lymphocyte responses .
10092768	0	CD28	57,61	IL-2	86,90	CD28	IL-2	940	3558	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|compound|END_ENTITY	The Jun_kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter : proof of cross-talk with the I kappa B kinase cascade .
10352279	0	CD28	0,4	IL-2	126,130	CD28	IL-2	940	3558	Gene	Gene	costimulation|compound|START_ENTITY augments|nsubj|costimulation augments|advcl|increasing increasing|advcl|enhancing enhancing|dobj|transactivation transactivation|compound|END_ENTITY	CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation .
10352279	0	CD28	0,4	IL-2	28,32	CD28	IL-2	940	3558	Gene	Gene	costimulation|compound|START_ENTITY augments|nsubj|costimulation augments|dobj|secretion secretion|compound|END_ENTITY	CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation .
10382746	0	CD28	77,81	IL-2	56,60	CD28	IL-2	940	3558	Gene	Gene	pathway|compound|START_ENTITY involved|nmod|pathway involved|nmod|regulation regulation|nmod|END_ENTITY	Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway .
10760803	0	CD28	0,4	IL-2	86,90	CD28	IL-2	940	3558	Gene	Gene	contribute|nsubj|START_ENTITY contribute|xcomp|cyclosporin_A-resistant cyclosporin_A-resistant|advcl|stabilizing stabilizing|dobj|mRNA mRNA|compound|END_ENTITY	CD28 and LFA-1 contribute to cyclosporin_A-resistant T cell growth by stabilizing the IL-2 mRNA through distinct signaling pathways .
10882412	0	CD28	8,12	IL-2	56,60	CD28	IL-2	940	3558	Gene	Gene	expression|nummod|START_ENTITY Loss|nmod|expression IFN|nsubj|Loss IFN|parataxis|induced induced|nmod|chain chain|compound|END_ENTITY	Loss of CD28 expression on CD8 -LRB- + -RRB- T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN , and increases susceptibility to activation-induced apoptosis .
10898499	0	CD28	37,41	IL-2	18,22	CD28	IL-2	12487(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Co-stimulation of IL-2 production by CD28 is independent of tyrosine-based signaling motifs in a murine T cell hybridoma .
11025487	0	CD28	75,79	IL-2	149,153	CD28	IL-2	940	3558	Gene	Gene	molecule|compound|START_ENTITY expression|nmod|molecule expression|nmod|END_ENTITY	Alcoholic_liver_cirrhosis is associated with a decreased expression of the CD28 costimulatory molecule , a lower ability of T cells to bind exogenous IL-2 , and increased soluble CD8 levels .
11135576	0	CD28	17,21	IL-2	64,68	CD28	IL-2	12487(Tax:10090)	16183(Tax:10090)	Gene	Gene	signal|compound|START_ENTITY signal|nmod|up-regulation up-regulation|nmod|END_ENTITY	Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines .
11587641	0	CD28	69,73	IL-2	94,98	CD28	IL-2	940	3558	Gene	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2 .
11937538	0	CD28	61,65	IL-2	109,113	CD28	IL-2	12487(Tax:10090)	16183(Tax:10090)	Gene	Gene	contribution|nmod|START_ENTITY mechanisms|dobj|contribution mechanisms|nmod|activation activation|compound|END_ENTITY	Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation .
12444145	0	CD28	51,55	IL-2	56,60	CD28	IL-2	940	3558	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
12538664	0	CD28	104,108	IL-2	64,68	CD28	IL-2	940	3558	Gene	Gene	ligation|nmod|START_ENTITY activation|nmod|ligation activation|compound|END_ENTITY	A single amino_acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible_costimulator -LRB- ICOS -RRB- .
12963692	0	CD28	15,19	IL-2	99,103	CD28	IL-2	940	3558	Gene	Gene	expression|nummod|START_ENTITY Restoration|nmod|expression Restoration|dep|effector effector|acl:relcl|reconstitutes reconstitutes|dobj|production production|compound|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
12963692	0	CD28	34,38	IL-2	99,103	CD28	IL-2	940	3558	Gene	Gene	expression|nmod|START_ENTITY Restoration|nmod|expression Restoration|dep|effector effector|acl:relcl|reconstitutes reconstitutes|dobj|production production|compound|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
1380533	0	CD28	4,8	IL-2	30,34	CD28	IL-2	940	3558	Gene	Gene	ligand|compound|START_ENTITY enhances|nsubj|ligand enhances|dobj|production production|compound|END_ENTITY	The CD28 ligand , B7 , enhances IL-2 production by providing a costimulatory signal to T cells .
15280538	0	CD28	17,21	IL-2	58,62	CD28	IL-2	940	3558	Gene	Gene	Translocation|nmod|START_ENTITY Translocation|nmod|END_ENTITY	Translocation of CD28 to lipid rafts and costimulation of IL-2 .
15383581	0	CD28	122,126	IL-2	65,69	CD28	IL-2	940	3558	Gene	Gene	link|nmod|START_ENTITY role|dep|link role|nmod|p75 p75|nmod|costimulator costimulator|nmod|induction induction|compound|END_ENTITY	Critical role of TNF receptor type-2 -LRB- p75 -RRB- as a costimulator for IL-2 induction and T cell survival : a functional link to CD28 .
15710339	0	CD28	79,83	IL-2	122,126	CD28	IL-2	940	3558	Gene	Gene	costimulatory|nummod|START_ENTITY costimulatory|acl|signaling signaling|xcomp|reduce reduce|dobj|expression expression|compound|END_ENTITY	Cyclosporin_A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells .
15814687	0	CD28	13,17	IL-2	63,67	CD28	IL-2	940	3558	Gene	Gene	Signals|nmod|START_ENTITY induce|nsubj|Signals induce|dobj|modification modification|nmod|promoter promoter|compound|END_ENTITY	Signals from CD28 induce stable epigenetic modification of the IL-2 promoter .
16585571	0	CD28	14,18	IL-2	84,88	CD28	IL-2	940	3558	Gene	Gene	outside|nummod|START_ENTITY Engagement|nmod|outside results|nsubj|Engagement results|nmod|up-regulation up-regulation|nmod|stability stability|compound|END_ENTITY	Engagement of CD28 outside of the immunological synapse results in up-regulation of IL-2 mRNA stability but not IL-2 transcription .
1676547	0	CD28	112,116	IL-2	76,80	CD28	IL-2	940	3558	Gene	Gene	activation|compound|START_ENTITY mediated|nmod|activation transcription|acl|mediated transcription|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
1676547	0	CD28	48,52	IL-2	76,80	CD28	IL-2	940	3558	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|evidence evidence|nmod|transcription transcription|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
1717561	0	CD28	0,4	IL-2	66,70	CD28	IL-2	940	3558	Gene	Gene	delivers|nsubj|START_ENTITY delivers|dobj|signal signal|acl|involved involved|nmod|production production|compound|END_ENTITY	CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells .
18025240	0	CD28	84,88	IL-2	126,130	CD28	IL-2	940	3558	Gene	Gene	signal|compound|START_ENTITY signal|acl:relcl|substituted substituted|nmod|END_ENTITY	Effective proliferation of human regulatory T cells requires a strong costimulatory CD28 signal that can not be substituted by IL-2 .
18097023	0	CD28	116,120	IL-2	36,40	CD28	IL-2	940	3558	Gene	Gene	costimulation|compound|START_ENTITY mediated|nmod|costimulation mediated|nsubjpass|export export|acl|stabilize stabilize|dobj|mRNA mRNA|compound|END_ENTITY	Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation .
2171783	0	CD28	0,4	IL-2	97,101	CD28	IL-2	940	3558	Gene	Gene	molecule|nummod|START_ENTITY molecule|nmod|production production|compound|END_ENTITY	CD28 molecule as a receptor-like function for accessory signals in cell-mediated augmentation of IL-2 production .
23851689	0	CD28	34,38	IL-2	65,69	CD28	IL-2	12487(Tax:10090)	16183(Tax:10090)	Gene	Gene	costimulation|compound|START_ENTITY requirement|nmod|costimulation enforces|dobj|requirement enforces|advcl|limiting limiting|dobj|production production|compound|END_ENTITY	Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production .
26500347	0	CD28	41,45	IL-2	17,21	CD28	IL-2	940	3558	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand .
7641692	0	CD28	55,59	IL-2	0,4	CD28	IL-2	940	3558	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	IL-2 gene expression and NF-kappa_B activation through CD28 requires reactive oxygen production by 5-lipoxygenase .
8946678	0	CD28	61,65	IL-2	119,123	CD28	IL-2	940	3558	Gene	Gene	tail|compound|START_ENTITY each|nmod|tail Phosphorylation|nmod|each required|nsubjpass|Phosphorylation required|nmod|secretion secretion|compound|END_ENTITY	Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28-induced T cell IL-2 secretion .
9199340	0	CD28	0,4	IL-2	65,69	CD28	IL-2	940	3558	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|upregulation upregulation|nmod|promoter promoter|appos|END_ENTITY	CD28 mediates transcriptional upregulation of the interleukin-2 -LRB- IL-2 -RRB- promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites .
9233628	0	CD28	83,87	IL-2	69,73	CD28	IL-2	12487(Tax:10090)	16183(Tax:10090)	Gene	Gene	element/AP|compound|START_ENTITY element/AP|compound|END_ENTITY	Involvement of Rel , Fos , and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP -1 sequence in human T cells .
9584155	0	CD28	55,59	IL-2	118,122	CD28	IL-2	940	3558	Gene	Gene	receptor|dep|START_ENTITY responsible|nmod|receptor regulation|amod|responsible regulation|nmod|expression expression|compound|END_ENTITY	Mechanism responsible for T-cell antigen receptor - and CD28 - or interleukin_1 _ -LRB- IL-1 -RRB- receptor-initiated regulation of IL-2 gene expression by NF-kappaB .
9862666	0	CD28	108,112	IL-2	66,70	CD28	IL-2	940	3558	Gene	Gene	up-regulation|nummod|START_ENTITY requirement|nmod|up-regulation activation|dep|requirement activation|compound|END_ENTITY	Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation : requirement for CD28 up-regulation of RE/AP .
19797296	0	CD28	80,84	IL-21	0,5	CD28	IL-21	940	59067	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhances|dobj|proliferation enhances|nsubj|END_ENTITY	IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28 + CD8 memory T cells throughout the adult age span .
23402380	0	CD28	38,42	IL-21	0,5	CD28	IL-21	940	59067	Gene	Gene	tumor|compound|START_ENTITY expansion|nmod|tumor promotes|dobj|expansion promotes|nsubj|END_ENTITY	IL-21 promotes the expansion of CD27 + CD28 + tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells .
10421790	0	CD28	99,103	IL-4	77,81	CD28	IL-4	940	3565	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression prevents|dobj|loss prevents|nsubj|END_ENTITY	Peripheral human CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T lymphocytes give rise to CD28 -LRB- - -RRB- progeny , but IL-4 prevents loss of CD28 expression .
10604995	0	CD28	140,144	IL-4	14,18	CD28	IL-4	940	3565	Gene	Gene	costimulation|compound|START_ENTITY presence|nmod|costimulation reversed|nmod|presence reversed|nsubjpass|Inhibition Inhibition|nmod|responses responses|compound|END_ENTITY	Inhibition of IL-4 responses after T cell priming in the context of LFA-1 costimulation is not reversed by restimulation in the presence of CD28 costimulation .
10725744	0	CD28	90,94	IL-4	54,58	CD28	IL-4	940	3565	Gene	Gene	costimulation|nummod|START_ENTITY mediate|nmod|costimulation mediate|dobj|expression expression|compound|END_ENTITY	Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells .
11254680	0	CD28	63,67	IL-4	84,88	CD28	IL-4	940	3565	Gene	Gene	stimulation|nmod|START_ENTITY differentiation|nmod|stimulation differentiation|dep|regulation regulation|nmod|expression expression|compound|END_ENTITY	Antigen-independent Th2 cell differentiation by stimulation of CD28 : regulation via IL-4 gene expression and mitogen-activated protein kinase activation .
15569772	0	CD28	40,44	IL-4	54,58	CD28	IL-4	12487(Tax:10090)	16189(Tax:10090)	Gene	Gene	ligands|nmod|START_ENTITY capacity|nmod|ligands capacity|acl|drive drive|dobj|expression expression|compound|END_ENTITY	The capacity of the natural ligands for CD28 to drive IL-4 expression in na ve and antigen-primed CD4 + and CD8 + T cells .
1646626	0	CD28	93,97	IL-4	0,4	CD28	IL-4	12487(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|dobj|START_ENTITY counterstructure|xcomp|T counterstructure|ccomp|upregulate upregulate|nsubj|END_ENTITY	IL-4 and IL-2 upregulate the expression of antigen B7 , the B cell counterstructure to T cell CD28 : an amplification mechanism for T-B cell interactions .
9126966	0	CD28	0,4	IL-4	45,49	CD28	IL-4	12487(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response .
17644042	0	CD28	41,45	Interleukin-15	0,14	CD28	Interleukin-15	940	3600	Gene	Gene	expands|dobj|START_ENTITY expands|nsubj|END_ENTITY	Interleukin-15 selectively expands CD57 + CD28 - CD4 + T cells , which are increased in active rheumatoid_arthritis .
7505212	0	CD28	21,25	Interleukin-1_and_B7	0,20	CD28	Interleukin-1 and B7	940	3552	Gene	Gene	interaction|nsubj|START_ENTITY END_ENTITY|parataxis|interaction	Interleukin-1_and_B7 / CD28 interaction regulate interleukin-6 production by human T cells .
15814667	0	CD28	25,29	Itk	0,3	CD28	Itk	12487(Tax:10090)	16428(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Itk is not essential for CD28 signaling in naive T cells .
14734751	0	CD28	25,29	OX40	17,21	CD28	OX40	12487(Tax:10090)	22163(Tax:10090)	Gene	Gene	rejection|compound|START_ENTITY role|nmod|rejection role|nmod|END_ENTITY	Critical role of OX40 in CD28 and CD154-independent rejection .
9820515	0	CD28	46,50	Phosphatidylinositol_3-kinase	0,29	CD28	Phosphatidylinositol 3-kinase	940	5293	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Phosphatidylinositol_3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK : functional and physical interaction of EMT with phosphatidylinositol_3-kinase .
24152837	0	CD28	54,58	TGF-beta	33,41	CD28	TGF-beta	940	7040	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	The effects of interleukin-10 or TGF-beta on anti-CD3 / CD28 induced activation of CD8 + CD28 - and CD8 + CD28 + T cells in allergic_asthma .
12670393	0	CD28	12,16	VAV	31,34	CD28	VAV	940	7409	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Independent CD28 signaling via VAV and SLP-76 : a model for in trans costimulation .
10725744	0	CD28	90,94	Vav	0,3	CD28	Vav	940	7409	Gene	Gene	costimulation|nummod|START_ENTITY mediate|nmod|costimulation kinase|xcomp|mediate kinase|nsubj|synergizes synergizes|compound|END_ENTITY	Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells .
11813163	0	CD28	20,24	Vav	0,3	CD28	Vav	940	7409	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated_kinase_kinase_1 .
9620604	0	CD28	28,32	Vav	105,108	CD28	Vav	940	7409	Gene	Gene	domain|compound|START_ENTITY regions|nmod|domain involved|nsubjpass|regions involved|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein .
7759998	0	CD28	0,4	acidic_sphingomyelinase	21,44	CD28	acidic sphingomyelinase	940	6609	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	CD28 signals through acidic_sphingomyelinase .
8596025	0	CD28	51,55	bcl-2	27,32	CD28	bcl-2	940	596	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of bcl-2 and bcl-x by CD3 , CD28 , and the IL-2_receptor in cloned CD4 + helper T cells .
11544297	0	CD28	0,4	c-Jun_N-terminal_kinase	25,48	CD28	c-Jun N-terminal kinase	12487(Tax:10090)	26419(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	CD28 is not required for c-Jun_N-terminal_kinase activation in T cells .
17617603	0	CD28	101,105	c-rel	84,89	CD28	c-rel	940	5966	Gene	Gene	activation|nummod|START_ENTITY END_ENTITY|nmod|activation	TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation .
17060905	0	CD28	0,4	filamin-A	22,31	CD28	filamin-A	940	2316	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse .
10760788	0	CD28	58,62	insulin-like_growth_factor-I_receptor	4,41	CD28	insulin-like growth factor-I receptor	940	3480	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The insulin-like_growth_factor-I_receptor is regulated by CD28 and protects activated T cells from apoptosis .
1716521	0	CD28	146,150	interferon-gamma	34,50	CD28	interferon-gamma	940	3458	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway amplification|nmod|activation mechanism|nmod|amplification induction|dep|mechanism induction|nmod|monocytes monocytes|amod|END_ENTITY	Selective induction of B7/BB -1 on interferon-gamma stimulated monocytes : a potential mechanism for amplification of T cell activation through the CD28 pathway .
9472663	0	CD28	183,187	interferon-gamma	151,167	CD28	interferon-gamma	940	3458	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
1650350	0	CD28	79,83	interleukin-2	14,27	CD28	interleukin-2	940	3558	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element .
1846244	0	CD28	84,88	interleukin-2	14,27	CD28	interleukin-2	940	3558	Gene	Gene	enhancer|nmod|START_ENTITY enhancer|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28 .
7821964	0	CD28	13,17	interleukin-2	80,93	CD28	interleukin-2	940	3558	Gene	Gene	co-stimulation|nummod|START_ENTITY Influence|nmod|co-stimulation regulated|nsubjpass|Influence regulated|nmod|END_ENTITY	Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2 .
8164687	0	CD28	26,30	interleukin-2	85,98	CD28	interleukin-2	940	3558	Gene	Gene	domain|nmod|START_ENTITY necessary|nsubj|domain necessary|nmod|costimulation costimulation|nmod|secretion secretion|compound|END_ENTITY	The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3 ' - kinase .
8626528	0	CD28	46,50	interleukin-2	118,131	CD28	interleukin-2	940	3558	Gene	Gene	element|compound|START_ENTITY binds|dobj|element factor|acl:relcl|binds appearance|nmod|factor correlates|nsubj|appearance correlates|nmod|production production|compound|END_ENTITY	Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production .
8626528	0	CD28	46,50	interleukin-2	79,92	CD28	interleukin-2	940	3558	Gene	Gene	element|compound|START_ENTITY element|nmod|enhancer enhancer|compound|END_ENTITY	Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production .
9199340	0	CD28	0,4	interleukin-2	50,63	CD28	interleukin-2	940	3558	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|upregulation upregulation|nmod|promoter promoter|compound|END_ENTITY	CD28 mediates transcriptional upregulation of the interleukin-2 -LRB- IL-2 -RRB- promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites .
9417115	0	CD28	48,52	interleukin-2	34,47	CD28	interleukin-2	940	3558	Gene	Gene	START_ENTITY|nsubj|transactivation transactivation|nmod|END_ENTITY	Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1 / CREB2 .
9850868	0	CD28	52,56	interleukin-2	24,37	CD28	interleukin-2	940	3558	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy .
9829977	0	CD28	117,121	interleukin-4	56,69	CD28	interleukin-4	940	3565	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28 .
16406844	0	CD28	90,94	interleukin-7	96,109	CD28	interleukin-7	940	3574	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Ex vivo expansion of dendritic-cell-activated antigen-specific CD4 + T cells with anti-CD3 / CD28 , interleukin-7 , and interleukin-15 : potential for adoptive T cell immunotherapy .
11280755	0	CD28	44,48	interleukin_2	79,92	CD28	interleukin 2	940	3558	Gene	Gene	costimulation|compound|START_ENTITY required|nsubjpass|costimulation required|nmod|secretion secretion|amod|END_ENTITY	T-cell activation by recombinant receptors : CD28 costimulation is required for interleukin_2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis .
1313075	0	CD28	0,4	interleukin_2	75,88	CD28	interleukin 2	940	3558	Gene	Gene	signal|nsubj|START_ENTITY signal|ccomp|regulate regulate|dobj|expression expression|amod|END_ENTITY	CD28 and T_cell_antigen_receptor signal transduction coordinately regulate interleukin_2 gene expression in response to superantigen stimulation .
15640801	0	CD28	0,4	interleukin_2	124,137	CD28	interleukin 2	940	3558	Gene	Gene	costimulation|nummod|START_ENTITY induces|nsubj|costimulation induces|dobj|expression expression|nmod|END_ENTITY	CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin_2 .
2170270	0	CD28	35,39	interleukin_2	44,57	CD28	interleukin 2	940	3558	Gene	Gene	antigen|appos|START_ENTITY antigen|nmod|END_ENTITY	Down-regulation of KOLT-2 antigen -LRB- CD28 -RRB- by interleukin_2 ; role of IL-2R -LRB- p70 -RRB- .
2830495	0	CD28	35,39	interleukin_2	90,103	CD28	interleukin 2	940	3558	Gene	Gene	involving|dobj|START_ENTITY proliferation|acl|involving associated|nsubjpass|proliferation associated|nmod|expression expression|amod|END_ENTITY	T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin_2 gene expression .
7539104	0	CD28	47,51	interleukin_2	14,27	CD28	interleukin 2	12487(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of interleukin_2 gene expression by CD28 costimulation in mouse T-cell clones : both nuclear and cytoplasmic RNAs are regulated with complex kinetics .
7623820	0	CD28	50,54	interleukin_2	83,96	CD28	interleukin 2	940	3558	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|amod|END_ENTITY	RelA is a potent transcriptional activator of the CD28 response element within the interleukin_2 promoter .
8900312	0	CD28	25,29	interleukin_2	52,65	CD28	interleukin 2	940	3558	Gene	Gene	pathways|nummod|START_ENTITY pathways|nmod|production production|amod|END_ENTITY	Glucocorticoids modulate CD28 mediated pathways for interleukin_2 production in human T cells : evidence for posttranscriptional regulation .
11120881	0	CD28	77,81	lymphocyte_function-associated_antigen_1	18,58	CD28	lymphocyte function-associated antigen 1	940	3683	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Costimulation via lymphocyte_function-associated_antigen_1 in the absence of CD28 ligation promotes anergy of naive CD4 + T cells .
18570590	0	CD28	42,46	p17	21,24	CD28	p17	940	54107	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression prevents|dobj|loss prevents|nsubj|END_ENTITY	HIV-1 matrix protein p17 prevents loss of CD28 expression during IL-2-induced maturation of na ve CD8 -LRB- + -RRB- T cells .
1830599	0	CD29	17,21	Beta_1_integrin	0,15	CD29	Beta 1 integrin	3688	3688	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Beta_1_integrin -LRB- CD29 -RRB- expression on human postnatal T cell subsets defined by selective CD45 isoform expression .
16211218	0	CD29	14,18	CD36	44,48	CD29	CD36	3688	948	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of CD29 on lymphoma cells and/or CD36 on microvascular endothels correlates with high serum LDH level in diffuse large B-cell_lymphomas -LRB- DLBCLs -RRB- and is frequent in de novo CD5-positive DLBCLs .
1370929	0	CD29	33,37	CD4	28,31	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Concomitant augmentation of CD4 + CD29 + helper inducer and diminution of CD4 + CD45RA + suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II .
1370929	0	CD29	33,37	CD4	72,75	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY augmentation|nmod|+ helper|nsubj|augmentation helper|dobj|inducer inducer|nmod|subset subset|compound|END_ENTITY	Concomitant augmentation of CD4 + CD29 + helper inducer and diminution of CD4 + CD45RA + suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II .
1376382	0	CD29	62,66	CD4	58,61	CD29	CD4	3688	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Differential age-change in the numbers of CD4 + CD45RA + and CD4 + CD29 + T cell subsets in human peripheral blood .
1698987	0	CD29	43,47	CD4	37,40	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased number of peripheral blood CD4 + CD29 + lymphocytes and increased in vitro spontaneous production of anti-DNA antibodies in patients with active systemic_lupus_erythematosus .
1700468	0	CD29	128,132	CD4	124,127	CD29	CD4	16412(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD45RA|compound|START_ENTITY CD45RA|compound|END_ENTITY	Purified human T cells stimulated with cross-linked anti-CD3 monoclonal antibody OKT3 : rIL-1 is a co-stimulatory factor for CD4 + CD29 + CD45RA - T cells .
1703056	0	CD29	32,36	CD4	28,31	CD29	CD4	3688	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Imbalance of CD4 + CD45R + and CD4 + CD29 + T helper cell subsets in patients with atopic_diseases .
1707762	0	CD29	46,50	CD4	42,45	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Differential responses of CD4 + CD45RA + and CD4 + CD29 + subsets to activated CD8 + cells : enhanced stimulation of the CD4 + CD45RA + subset by cells from patients with multiple_sclerosis .
17087927	0	CD29	101,105	CD4	0,3	CD29	CD4	3688	920	Gene	Gene	beta|appos|START_ENTITY role|nmod|beta fibronectin|dep|role require|nmod|fibronectin require|nsubj|lymphocytes lymphocytes|compound|END_ENTITY	CD4 + lymphocytes require platelets for adhesion to immobilized fibronectin in flow : role of beta -LRB- 1 -RRB- -LRB- CD29 -RRB- - , beta -LRB- 2 -RRB- -LRB- CD18 -RRB- - related integrins and non-integrin receptors .
1712366	0	CD29	43,47	CD4	39,42	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD21 + -LRB- B2 antigen + -RRB- cell decrement and CD4 + CD29 + -LRB- helper-inducer -RRB- cell increment suggest an activation of cell immune reactivity in multiple_sclerosis .
25386078	0	CD29	29,33	CD4	23,26	CD29	CD4	3688	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative_colitis patients .
2566120	0	CD29	54,58	CD4	71,74	CD29	CD4	3688	920	Gene	Gene	molecule|compound|START_ENTITY molecule|nmod|+ +|compound|END_ENTITY	Suppressor effects and cyclic_AMP accumulation by the CD29 molecule of CD4 + lymphocytes .
2570801	0	CD29	81,85	CD4	77,80	CD29	CD4	3688	920	Gene	Gene	CD45R|compound|START_ENTITY CD45R|compound|END_ENTITY	Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4 + CD29 + CD45R - memory T lymphocytes .
7684891	0	CD29	17,21	CD4	13,16	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Imbalance of CD4 + CD29 + and CD4 + CD45RA + T-helper cell subsets in peripheral blood of patients with severe atopic_dermatitis .
7693106	0	CD29	15,19	CD4	0,3	CD29	CD4	3688	920	Gene	Gene	CD45RA|nummod|START_ENTITY +|appos|CD45RA +|compound|END_ENTITY	CD4 + , CD45RA + , CD29 - T-cell_lymphocytic_leukemia functioning as T suppressor inducer for B-cell immunoglobulin synthesis .
9292944	0	CD29	104,108	CD4	99,102	CD29	CD4	3688	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased production of B-cell growth factor by T lymphocytes in Graves ' thyroid : possible role of CD4 + CD29 + cells .
9467397	0	CD29	0,4	CD4	19,22	CD29	CD4	3688	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD29 expression on CD4 + gingival lymphocytes supports migration of activated memory T lymphocytes to diseased periodontal tissue .
9473864	0	CD29	36,40	CD4	32,35	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increase in the helper inducer -LRB- CD4 + CD29 + -RRB- T lymphocytes in smokers .
9634196	0	CD29	115,119	CD4	29,32	CD29	CD4	3688	920	Gene	Gene	using|nmod|START_ENTITY reactive|xcomp|using reactive|nsubj|induction induction|nmod|lines lines|compound|END_ENTITY	Efficient induction of human CD4 + T cell lines reactive with a self-K-ras-derived peptide in vitro , using a mAb to CD29 .
9886155	0	CD29	24,28	CD4	20,23	CD29	CD4	3688	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increase in memory -LRB- CD4 + CD29 + and CD4 + CD45RO + -RRB- T and naive -LRB- CD4 + CD45RA + -RRB- T-cell subpopulations in smokers .
23160057	0	CD29	61,65	CD49b	30,35	CD29	CD49b	3688	3673	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of a -LRB- CD49b -RRB- , a -LRB- CD49d -RRB- and b -LRB- CD29 -RRB- integrin subunits on peripheral blood T lymphocytes in clinically stable mild-to-moderate persistent asthma .
1722959	0	CD29	61,65	CD8	0,3	CD29	CD8	3688	925	Gene	Gene	population|compound|START_ENTITY expanded|nsubjpass|population lymphocytes|parataxis|expanded lymphocytes|nsubj|END_ENTITY	CD8 lymphocytes during Epstein_Barr_virus _ -LRB- EBV -RRB- infection : A CD29 positive population is expanded in acute infectious_mononucleosis .
8343185	0	CD29	77,81	CD8	71,74	CD29	CD8	3688	925	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Presence of estrogen-binding sites on macrophage-like synoviocytes and CD8 + , CD29 + , CD45RO + T lymphocytes in normal and rheumatoid_synovium .
9175023	0	CD29	20,24	CD8	36,39	CD29	CD8	3688	925	Gene	Gene	density|compound|START_ENTITY density|nmod|+ +|compound|END_ENTITY	Correlation between CD29 density on CD8 + lymphocytes and serum IgG in systemic_lupus_erythematosus .
2570801	0	CD29	81,85	IL-4	69,73	CD29	IL-4	3688	3565	Gene	Gene	CD45R|compound|START_ENTITY END_ENTITY|nmod|CD45R	Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4 + CD29 + CD45R - memory T lymphocytes .
11501844	0	CD29	37,41	beta1-integrin	20,34	CD29	beta1-integrin	3688	3688	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of beta1-integrin -LRB- = CD29 -RRB- in serous adenocarcinomas of the ovary .
15951437	0	CD2AP	24,29	CD2-associated_protein	0,22	CD2AP	CD2-associated protein	12488(Tax:10090)	12488(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CD2-associated_protein -LRB- CD2AP -RRB- expression in podocytes rescues lethality of CD2AP_deficiency .
22880102	0	CD2AP	40,45	E2F1	58,62	CD2AP	E2F1	23607	1869	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Transcriptional activation of the human CD2AP promoter by E2F1 .
10997929	0	CD2AP	0,5	nephrin	24,31	CD2AP	nephrin	12488(Tax:10090)	54631(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere .
16997854	0	CD3	127,130	C5a_anaphylatoxin_receptor	90,116	CD3	C5a anaphylatoxin receptor	12501(Tax:10090)	12273(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a_anaphylatoxin_receptor -LRB- CD88 -RRB- in CD3 + murine T cells .
9176107	0	CD3	137,140	CD25	148,152	CD3	CD25	12503(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
11119259	0	CD3	68,71	CD4	85,88	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD8|amod|START_ENTITY CD8|compound|END_ENTITY	Synchronous deletion of Mtv-superantigen-reactive thymocytes in the CD3 -LRB- medium/high -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- subset .
11222500	0	CD3	51,54	CD4	57,60	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	thymocytes|nmod|START_ENTITY thymocytes|nsubj|CD8 CD8|compound|END_ENTITY	Heterogeneity within medullary-type TCRalphabeta -LRB- + -RRB- CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- + -RRB- thymocytes in normal mouse thymus .
12150889	0	CD3	128,131	CD4	134,137	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Initiation of NALT organogenesis is independent of the IL-7R , LTbetaR , and NIK signaling pathways but requires the Id2 gene and CD3 -LRB- - -RRB- CD4 -LRB- + -RRB- CD45 -LRB- + -RRB- cells .
1347302	1	CD3	110,113	CD4	204,207	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway Activation|nmod|cells inhibits|nsubj|Activation inhibits|dobj|elimination elimination|nmod|END_ENTITY	Activation of T cells by the CD3 pathway inhibits anti-CD4-mediated T cell elimination and down-regulation of cell surface CD4 .
1350461	0	CD3	17,20	CD4	115,118	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	Co-engagement|nmod|START_ENTITY enhances|nsubj|Co-engagement enhances|dobj|frequency frequency|nmod|activation activation|nmod|+ +|compound|END_ENTITY	Co-engagement of CD3 with LFA-1 or ICAM-1 adhesion molecules enhances the frequency of activation of single murine CD4 + and CD8 + T cells and induces synthesis of IL-3 and IFN-gamma but not IL-4 or IL-6 .
15031541	4	CD3	529,532	CD4	535,538	CD3	CD4	396518(Tax:9031)	395362(Tax:9031)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	The percentage of CD3 -LRB- + -RRB- cells , CD4 -LRB- + -RRB- cells , CD8_alpha -LRB- + -RRB- cells , CD8_beta -LRB- + -RRB- , and CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells was 76 % , 41 % , 14 % , 5 % , and 15 % , respectively .
1673982	0	CD3	69,72	CD4	75,78	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|dep|- -|compound|END_ENTITY	Distinct subsets of accessory cells activate Thy-1 + triple negative -LRB- CD3 - , CD4 - , CD8 - -RRB- cells and Th-1 delayed-type_hypersensitivity effector T cells .
1691152	0	CD3	26,29	CD4	31,34	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immune surveillance : both CD3 + CD4 + and CD3 + CD8 + T cells control in vivo growth of P815 mastocytoma .
1696186	0	CD3	91,94	CD4	18,21	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	Subpopulations|dep|START_ENTITY Subpopulations|nmod|cells cells|nummod|END_ENTITY	Subpopulations of CD4 + cells in lpr/lpr mice : differences in expression of T_cell_receptor / CD3 complex and proliferative responses .
1696293	1	CD3	73,76	CD4	32,35	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|appos|+ contain|dobj|+ murine|parataxis|contain murine|dobj|END_ENTITY	Adult murine CD4 - , CD8 - thymocytes contain an NK1 .1 + , CD3 + , CD5hi , CD44hi , TCR-V beta 8 + subset .
1835792	0	CD3	29,32	CD4	19,22	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	Lymphocytes|dep|START_ENTITY Lymphocytes|nmod|CD8 CD8|compound|END_ENTITY	Lymphocytes with a CD4 + CD8 - CD3 - phenotype are effectors of experimental cutaneous_graft-versus-host_disease .
2088486	0	CD3	86,89	CD4	20,23	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	subpopulation|dep|START_ENTITY Ontogeny|parataxis|subpopulation Ontogeny|nmod|CD8-CD3 CD8-CD3|compound|END_ENTITY	Ontogeny of a novel CD4 + CD8-CD3 - thymocyte subpopulation : a comparison with CD4 - CD8 + CD3 - thymocytes .
2088486	0	CD3	86,89	CD4	76,79	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	subpopulation|dep|START_ENTITY subpopulation|dep|comparison comparison|nmod|END_ENTITY	Ontogeny of a novel CD4 + CD8-CD3 - thymocyte subpopulation : a comparison with CD4 - CD8 + CD3 - thymocytes .
24212096	0	CD3	35,38	CD4	72,75	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	chains|compound|START_ENTITY Characteristics|nmod|chains Characteristics|nmod|T T|compound|END_ENTITY	Characteristics of TCR/CD3 complex CD3 -LCB- varepsilon -RCB- chains of regulatory CD4 + T -LRB- Treg -RRB- lymphocytes : role in Treg differentiation in vitro and impact on Treg in vivo .
25168425	0	CD3	25,28	CD4	30,33	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	The role of intrahepatic CD3 + / CD4 - / CD8 - double_negative_T -LRB- DN_T -RRB- cells in enhanced acetaminophen toxicity .
2523934	0	CD3	45,48	CD4	50,53	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY analysis|nmod|+ analysis|appos|END_ENTITY	Phenotypic and functional analysis of murine CD3 + , CD4 - , CD8 - TCR-gamma delta-expressing peripheral T cells .
25445913	0	CD3	39,42	CD4	32,35	CD3	CD4	396518(Tax:9031)	395362(Tax:9031)	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of novel chicken CD4 -LRB- + -RRB- CD3 -LRB- - -RRB- blood population with NK cell like features .
26901413	0	CD3	98,101	CD4	105,108	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	IL-17 Induction by ArtinM is Due to Stimulation of IL-23_and_IL-1 Release and/or Interaction with CD3 in CD4 + T Cells .
2966738	0	CD3	2,5	CD4	88,91	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|intermediate intermediate|nmod|generation generation|nmod|cells cells|nummod|+8 +8|compound|END_ENTITY	A CD3 - subset of CD4-8 + thymocytes : a rapidly cycling intermediate in the generation of CD4 +8 + cells .
3260917	0	CD3	18,21	CD4	24,27	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|appos|- -|compound|END_ENTITY	Peripheral murine CD3 + , CD4 - , CD8 - T lymphocytes express novel T cell receptor gamma delta structures .
8436820	0	CD3	47,50	CD4	42,45	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Characterization of an unusual cell type -LRB- CD4 + CD3 - -RRB- expanded by helminth infection and related to the parasite stress response .
8647197	0	CD3	94,97	CD4	109,112	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	complex|advmod|START_ENTITY complex|nmod|+ +|compound|END_ENTITY	CD4-dependent and - independent association of protein tyrosine kinases to the T_cell_receptor / CD3 complex of CD4 + mouse T lymphocytes .
9144481	0	CD3	88,91	CD4	142,145	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	monoclonal|nummod|START_ENTITY antibody-induced|nmod:npmod|monoclonal antigen-mediated|dep|antibody-induced activation|amod|antigen-mediated activation|nmod|cells cells|compound|END_ENTITY	Wortmannin , a phosphatidylinositol_3-kinase inhibitor , blocks antigen-mediated , but not CD3 monoclonal antibody-induced , activation of murine CD4 + T cells .
9300678	0	CD3	34,37	CD4	39,42	CD3	CD4	12501(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY population|nummod|+ population|compound|END_ENTITY	Administration of IL-12 induces a CD3 + CD4 - CD8 - B220 + lymphoid population capable of eliciting cytolysis against Fas-positive tumor cells .
9176107	0	CD3	137,140	CD44	142,146	CD3	CD44	12503(Tax:10090)	12505(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
15031541	4	CD3	529,532	CD8	541,544	CD3	CD8	396518(Tax:9031)	428800(Tax:9031)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The percentage of CD3 -LRB- + -RRB- cells , CD4 -LRB- + -RRB- cells , CD8_alpha -LRB- + -RRB- cells , CD8_beta -LRB- + -RRB- , and CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells was 76 % , 41 % , 14 % , 5 % , and 15 % , respectively .
18483926	5	CD3	661,664	CD8	673,676	CD8	CD3	403158(Tax:9031)	396518(Tax:9031)	Gene	Gene	CD4|compound|START_ENTITY CD4|dep|T-cells T-cells|amod|END_ENTITY	In CD4 -LRB- + -RRB- T-cell-deficient chickens , the phenotypes were CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- Vss1-alphassTCR -LRB- + -RRB- T-cells and CD3 -LRB- - -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells .
24297179	0	CD3	105,108	CD8	115,118	CD3	CD8	12501(Tax:10090)	925	Gene	Gene	CD4|compound|START_ENTITY generation|nmod|CD4 CD8|nmod|generation cAMP_responsive_element_modulator|nmod|CD8 cAMP_responsive_element_modulator|dep|END_ENTITY	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
24297179	0	CD3	105,108	CD8	76,79	CD3	CD8	12501(Tax:10090)	925	Gene	Gene	CD4|compound|START_ENTITY generation|nmod|CD4 END_ENTITY|nmod|generation	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
2972326	0	CD3	60,63	CD8	66,69	CD3	CD8	12501(Tax:10090)	925	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	In vitro inhibition of normal human hematopoiesis by marrow CD3 + , CD8 + , HLA-DR + , HNK1 + lymphocytes .
1682383	1	CD3	66,69	IFN-gamma	105,114	CD3	IFN-gamma	12501(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY produce|nsubj|+ produce|dobj|END_ENTITY	Murine CD3 + , gamma/delta TCR + T cells produce IFN-gamma and IL-5 .
9354470	0	CD3	35,38	LTbeta	40,46	CD3	LTbeta	12501(Tax:10090)	16994(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Developing lymph nodes collect CD4 + CD3 - LTbeta + cells that can differentiate to APC , NK cells , and follicular cells but not T or B cells .
8073519	0	CD3	79,82	NK1	75,78	CD3	NK1	12501(Tax:10090)	17059(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Demonstration of MHC class I-specific cytolytic activity in IL-2-activated NK1 + CD3 + cells and evidence of usage of T and NK cell receptors .
14676780	0	CD3	26,29	TNFalpha	14,22	CD3	TNFalpha	12501(Tax:10090)	21926(Tax:10090)	Gene	Gene	+|compound|START_ENTITY Expression|nmod|+ Expression|nmod|END_ENTITY	Expression of TNFalpha by CD3 + and F4/80 + cells following irradiation preconditioning and allogeneic spleen cell transplantation .
2532601	0	CD3	22,25	T_cell_receptor	44,59	TcR	T cell receptor	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Surface expression of CD3 in the absence of T_cell_receptor -LRB- TcR -RRB- : evidence for sorting of partial TcR/CD3 complexes in a post-endoplasmic reticulum compartment .
2532601	0	CD3	22,25	TcR	61,64	TcR	TcR	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Surface expression of CD3 in the absence of T_cell_receptor -LRB- TcR -RRB- : evidence for sorting of partial TcR/CD3 complexes in a post-endoplasmic reticulum compartment .
20724552	0	CD3	63,66	cystic_fibrosis_transmembrane_conductance_regulator	8,59	CD3	cystic fibrosis transmembrane conductance regulator	12501(Tax:10090)	12638(Tax:10090)	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ END_ENTITY|nmod|lymphocytes	Lack of cystic_fibrosis_transmembrane_conductance_regulator in CD3 + lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses .
18214800	0	CD3	86,89	interleukin-2	9,22	CD3	interleukin-2	12501(Tax:10090)	16183(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Impaired interleukin-2 synthesis and T cell proliferation following antibody-mediated CD3 and CD2 or CD28 cross-linking in trans : evidence that T cell activation requires the engagement of costimulatory molecules within the immunological synapse .
8814252	0	CD3/zeta	90,98	T_cell_receptor	74,89	CD3/zeta	T cell receptor	919	6962	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T_cell_receptor / CD3/zeta complex .
16796648	0	CD30	59,63	ALK	94,97	CD30	ALK	943	238	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Cutaneous presentation on the eyelid of primary , systemic , CD30 + , anaplastic_lymphoma kinase -LRB- ALK -RRB- - negative , anaplastic_large-cell_lymphoma -LRB- ALCL -RRB- .
24492285	0	CD30	52,56	BAG-3	15,20	CD30	BAG-3	943	9531	Gene	Gene	expression|compound|START_ENTITY Correlation|nmod|expression Correlation|nmod|END_ENTITY	Correlation of BAG-3 and heat_shock_protein_70 with CD30 expression in T-cell_lymphomas .
23988031	0	CD30	112,116	CD15	106,110	CD30	CD15	943	2526	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF2 -RRB- and syndecan-1 -LRB- SDC1 -RRB- are potential biomarkers for putative circulating CD15 + / CD30 + cells in poor outcome Hodgkin_lymphoma patients .
9327746	7	CD30	771,775	CD15	764,768	CD20	CD30	54474	943	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Eighty-three percent of the cases showed a classical immunophenotype -LRB- CD15 + , CD30 + , CD20 - -RRB- , twelve percent lacked CD15 positivity -LRB- CD15 - , CD30 + , CD20 - -RRB- , and five percent showed other combinations .
10080930	0	CD30	14,18	CD153	27,32	CD30	CD153	21941(Tax:10090)	21949(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|nmod|cells cells|dep|END_ENTITY	Expression of CD30 ligand -LRB- CD153 -RRB- on murine activated T cells .
10878352	0	CD30	37,41	CD153	14,19	CD30	CD153	943	944	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Engagement of CD153 -LRB- CD30_ligand -RRB- by CD30 + T cells inhibits class switch DNA recombination and antibody production in human IgD + IgM + B cells .
11754357	0	CD30	8,12	CD153	22,27	CD30	CD153	943	944	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30 .
11754357	0	CD30	85,89	CD153	22,27	CD30	CD153	943	944	Gene	Gene	signaling|nmod|START_ENTITY affinity|acl|signaling END_ENTITY|nmod|affinity	Soluble CD30 binds to CD153 with high affinity and blocks transmembrane signaling by CD30 .
12392508	0	CD30	31,35	CD153	44,49	CD30	CD153	21941(Tax:10090)	21949(Tax:10090)	Gene	Gene	murine|dep|START_ENTITY gene|amod|murine gene|appos|END_ENTITY	Characterization of the murine CD30 ligand -LRB- CD153 -RRB- gene : gene structure and expression .
18086588	0	CD30	0,4	CD1a	19,23	CD30	CD1a	943	909	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	CD30 expression on CD1a + and CD8 + cells in atopic_dermatitis and correlation with disease severity .
9498756	0	CD30	41,45	CD28	67,71	CD30	CD28	943	940	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines .
7528856	0	CD30	29,33	CD30	45,49	CD30	CD30	943	943	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines .
7528856	0	CD30	45,49	CD30	29,33	CD30	CD30	943	943	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression and regulation of CD30 ligand and CD30 in human leukemia-lymphoma cell lines .
20639486	0	CD30	12,16	CD30_ligand	0,11	CD30	CD30 ligand	21941(Tax:10090)	21949(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	CD30_ligand / CD30 plays a critical role in Th17 differentiation in mice .
14726963	0	CD30	32,36	CD4	38,41	CD30	CD4	943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Pathophysiological functions of CD30 + CD4 + T cells in rheumatoid_arthritis .
15280854	0	CD30	55,59	CD4	32,35	CD30	CD4	943	920	Gene	Gene	lymphoproliferative_disorder|compound|START_ENTITY END_ENTITY|dep|lymphoproliferative_disorder	Progressive epidermotropic CD8 + / CD4 - primary cutaneous CD30 + lymphoproliferative_disorder in a patient with sarcoidosis .
16364153	0	CD30	5,9	CD4	0,3	CD30	CD4	943	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + CD30 + T cells perpetuate IL-5 production in Dermatophagoides_pteronyssinus allergic patients .
17068147	0	CD30	6,10	CD4	60,63	CD30	CD4	21941(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY critical|nsubj|signaling critical|nmod|adoptively adoptively|acl|transferred transferred|dobj|cells cells|nummod|END_ENTITY	Early CD30 signaling is critical for adoptively transferred CD4 + CD25 + regulatory T cells in prevention of acute_graft-versus-host_disease .
18078420	0	CD30	0,4	CD4	19,22	CD30	CD4	943	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	CD30 on stimulated CD4 + T lymphocytes in newborns regarding atopic_heredity .
18201430	0	CD30	24,28	CD4	51,54	CD30	CD4	943	920	Gene	Gene	molecules|compound|START_ENTITY expression|nmod|molecules expression|nmod|END_ENTITY	Increased expression of CD30 and CD57 molecules on CD4 -LRB- + -RRB- T cells from children with atopic_asthma : a preliminary report .
18292503	0	CD30	20,24	CD4	45,48	CD30	CD4	21941(Tax:10090)	12504(Tax:10090)	Gene	Gene	synergy|nmod|START_ENTITY signals|nsubj|synergy signals|nmod|homeostasis homeostasis|compound|END_ENTITY	Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella .
1979248	0	CD30	8,12	CD4	30,33	CD30	CD4	943	920	Gene	Gene	Ki-1|appos|START_ENTITY Ki-1|dep|T T|appos|+ +|dep|+ +|compound|END_ENTITY	A Ki-1 -LRB- CD30 -RRB- - positive T -LRB- E + , CD4 + , Ia + -RRB- - cell line , DL-40 , established from aggressive_large_cell_lymphoma .
20625494	0	CD30	94,98	CD4	54,57	CD30	CD4	943	920	Gene	Gene	form|nmod|START_ENTITY correlates|dobj|form correlates|nsubj|expression expression|nmod|ganglioside_GM1 ganglioside_GM1|nmod|cells cells|compound|END_ENTITY	Increased expression of ganglioside_GM1 in peripheral CD4 + T cells correlates soluble form of CD30 in Systemic_Lupus_Erythematosus patients .
20631311	0	CD30	0,4	CD4	56,59	CD30	CD4	943	920	Gene	Gene	discriminates|compound|START_ENTITY heat_shock|nsubj|discriminates heat_shock|dobj|cells cells|compound|END_ENTITY	CD30 discriminates heat_shock protein 60-induced FOXP3 + CD4 + T cells with a regulatory phenotype .
25076300	0	CD30	56,60	CD4	65,68	CD30	CD4	943	920	Gene	Gene	lymphoma|compound|START_ENTITY lymphoma|appos|END_ENTITY	Transformation of small B-cell_lymphoma into large cell CD30 , CD4 , Epstein-Barr_virus-negative lymphoma .
25999672	0	CD30	70,74	CD4	66,69	CD30	CD4	943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracellular IL-4 , IL-5 , and IFN-y as the main characteristic of CD4 + CD30 + T cells after allergen stimulation in patients with vernal_keratoconjunctivitis .
26857493	0	CD30	15,19	CD4	34,37	CD30	CD4	21941(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Requirement|nmod|expression Requirement|nmod|cells cells|compound|END_ENTITY	Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental_autoimmune_encephalomyelitis .
7821763	0	CD30	27,31	CD4	41,44	CD30	CD4	943	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Preferential expression of CD30 by human CD4 + T cells producing Th2-type cytokines .
12207739	0	CD30	51,55	CD44	14,18	CD30	CD44	943	960	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD44 and CD44v6 in primary cutaneous CD30 positive T-cell_lymphoproliferative_disorders .
11756778	0	CD30	48,52	CD56	55,59	CD30	CD56	943	4684	Gene	Gene	+|compound|START_ENTITY Epstein-Barr_virus-associated|appos|+ Epstein-Barr_virus-associated|appos|+ +|compound|END_ENTITY	Aggressive Epstein-Barr_virus-associated , CD8 + , CD30 + , CD56 + , surface CD3 - , natural killer -LRB- NK -RRB- - like cytotoxic T-cell_lymphoma .
10192335	0	CD30	19,23	CD8	73,76	CD30	CD8	943	925	Gene	Gene	Signalling|nmod|START_ENTITY protects|csubj|Signalling protects|nmod|autoimmune_diabetes autoimmune_diabetes|acl|mediated mediated|nmod|cells cells|compound|END_ENTITY	Signalling through CD30 protects against autoimmune_diabetes mediated by CD8 T cells .
11555396	0	CD30	90,94	CD8	56,59	CD30	CD8	943	925	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|Segregation Segregation|nmod|mechanisms mechanisms|nmod|clone clone|compound|END_ENTITY	Segregation of effector mechanisms in a tumour-specific CD8 + T-cell clone correlates with CD30 expression .
11756778	0	CD30	48,52	CD8	42,45	CD30	CD8	943	925	Gene	Gene	+|compound|START_ENTITY Epstein-Barr_virus-associated|appos|+ Epstein-Barr_virus-associated|appos|+ +|compound|END_ENTITY	Aggressive Epstein-Barr_virus-associated , CD8 + , CD30 + , CD56 + , surface CD3 - , natural killer -LRB- NK -RRB- - like cytotoxic T-cell_lymphoma .
15280854	0	CD30	55,59	CD8	27,30	CD30	CD8	943	925	Gene	Gene	lymphoproliferative_disorder|compound|START_ENTITY CD4|dep|lymphoproliferative_disorder CD4|compound|END_ENTITY	Progressive epidermotropic CD8 + / CD4 - primary cutaneous CD30 + lymphoproliferative_disorder in a patient with sarcoidosis .
17673391	0	CD30	79,83	CD8	44,47	CD30	CD8	943	925	Gene	Gene	T-cell_lymphoma|nmod|START_ENTITY T-cell_lymphoma|compound|END_ENTITY	Primary cutaneous aggressive epidermotropic CD8 + T-cell_lymphoma with a CD15 -LRB- + -RRB- CD30 -LRB- - -RRB- phenotype .
26288406	0	CD30	25,29	CD8	18,21	CD30	CD8	943	925	Gene	Gene	Anaplastic_Large_Cell_Lymphoma|compound|START_ENTITY END_ENTITY|dep|Anaplastic_Large_Cell_Lymphoma	Primary Cutaneous CD8 -LRB- + -RRB- CD30 -LRB- + -RRB- Anaplastic_Large_Cell_Lymphoma : An Unusual Case with a High Ki-67 index-A Short Review .
26485239	0	CD30	43,47	CD8	38,41	CD30	CD8	943	925	Gene	Gene	Lymphoproliferative|compound|START_ENTITY Disorders|nsubj|Lymphoproliferative Characterization|parataxis|Disorders Characterization|nmod|+ +|compound|END_ENTITY	Characterization of Primary Cutaneous CD8 + / CD30 + Lymphoproliferative Disorders .
7964515	0	CD30	0,4	CD8	19,22	CD30	CD8	943	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD30 expression by CD8 + T cells producing type 2 helper cytokines .
7964515	1	CD30	101,105	CD8	97,100	CD30	CD8	943	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Evidence for large numbers of CD8 + CD30 + T cell clones in human_immunodeficiency_virus_infection .
8871616	0	CD30	0,4	CD8	25,28	CD30	CD8	943	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD30 expression on human CD8 + T cells isolated from peripheral blood lymphocytes of normal donors .
11756152	0	CD30	0,4	CXCR4	50,55	CD30	CXCR4	943	7852	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 .
20631311	0	CD30	0,4	FOXP3	49,54	CD30	FOXP3	943	50943	Gene	Gene	discriminates|compound|START_ENTITY heat_shock|nsubj|discriminates heat_shock|dobj|cells cells|compound|END_ENTITY	CD30 discriminates heat_shock protein 60-induced FOXP3 + CD4 + T cells with a regulatory phenotype .
12193714	0	CD30	16,20	IL-13	51,56	CD30	IL-13	943	3596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 _ mitogen-activated_protein_kinase-dependent mechanism .
11882036	0	CD30	37,41	IL-18	14,19	CD30	IL-18	943	3606	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of IL-18 on IL-12-induced CD30 expression and IL-4 and IFN-gamma production by allergen and PPD specific T cells .
25999672	0	CD30	70,74	IL-4	14,18	CD30	IL-4	943	3565	Gene	Gene	cells|compound|START_ENTITY characteristic|nmod|cells Intracellular|nmod|characteristic Intracellular|dobj|END_ENTITY	Intracellular IL-4 , IL-5 , and IFN-y as the main characteristic of CD4 + CD30 + T cells after allergen stimulation in patients with vernal_keratoconjunctivitis .
9036953	0	CD30	25,29	IL-4	60,64	CD30	IL-4	943	3565	Gene	Gene	expression|nummod|START_ENTITY regulation|nmod|expression T|nsubj|regulation T|nmod|END_ENTITY	Reciprocal regulation of CD30 expression on CD4 + T cells by IL-4 and IFN-gamma .
10676635	0	CD30	79,83	JAK2	71,75	CD30	JAK2	943	3717	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30 + Hodgkin cells .
15920551	0	CD30	39,43	JunB	0,4	CD30	JunB	943	3726	Gene	Gene	lymphomas|compound|START_ENTITY feature|nmod|lymphomas feature|nsubj|expression expression|compound|END_ENTITY	JunB expression is a common feature of CD30 + lymphomas and lymphomatoid_papulosis .
16140928	0	CD30	133,137	JunB	0,4	CD30	JunB	943	3726	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic_large_cell_lymphoma and reed-sternberg cells of Hodgkin_lymphoma .
16982741	0	CD30	18,22	JunB	123,127	CD30	JunB	943	3726	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|level level|compound|END_ENTITY	The expression of CD30 in anaplastic_large_cell_lymphoma is regulated by nucleophosmin-anaplastic lymphoma kinase-mediated JunB level in a cell type-specific manner .
17965727	0	CD30	19,23	JunB	50,54	CD30	JunB	943	3726	Gene	Gene	islands|compound|START_ENTITY islands|nmod|expression expression|compound|END_ENTITY	Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin_lymphoma and anaplastic_large_cell_lymphoma .
17965727	0	CD30	73,77	JunB	50,54	CD30	JunB	943	3726	Gene	Gene	induction|nummod|START_ENTITY drives|dobj|induction drives|nsubj|Hypomethylation Hypomethylation|nmod|islands islands|nmod|expression expression|compound|END_ENTITY	Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin_lymphoma and anaplastic_large_cell_lymphoma .
1758054	0	CD30	42,46	Ki-1	36,40	CD30	Ki-1	943	943	Gene	Gene	lymphoma|appos|START_ENTITY lymphoma|compound|END_ENTITY	-LSB- Temporary spontaneous remission in Ki-1 -LRB- CD30 -RRB- lymphoma with gastric_lesion -RSB- .
2537734	0	CD30	6,10	Ki-1	0,4	CD30	Ki-1	943	943	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Ki-1 -LRB- CD30 -RRB- antigen is released by Ki-1-positive tumor cells in vitro and in vivo .
2849300	0	CD30	6,10	Ki-1	0,4	CD30	Ki-1	943	943	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Ki-1 -LRB- CD30 -RRB- antigen is regularly expressed by tumor cells of embryonal_carcinoma .
7665144	0	CD30	0,4	Ki-1	6,10	CD30	Ki-1	943	943	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	CD30 -LRB- Ki-1 -RRB- expression in adult_T-cell_leukaemia / lymphoma is associated with distinctive immunohistological and clinical characteristics .
8390600	0	CD30	38,42	Ki-1	32,36	CD30	Ki-1	943	943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Anaplastic_large_cell_lymphoma -LRB- Ki-1 + / CD30 + -RRB- in childhood .
9094181	0	CD30	54,58	Ki-1	48,52	CD30	Ki-1	943	943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	Carbamazepine-induced lymphadenopathy mimicking Ki-1 -LRB- CD30 + -RRB- T-cell_lymphoma .
9415340	0	CD30	55,59	Ki-1	61,65	CD30	Ki-1	943	943	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Traumatic eosinophilic_granuloma_of_the_oral_mucosa : a CD30 + -LRB- Ki-1 -RRB- lymphoproliferative_disorder ?
2169996	0	CD30	28,32	Ki-1_antigen	14,26	CD30	Ki-1 antigen	943	943	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Ki-1_antigen -LRB- CD30 -RRB- in mesenchymal_tumors .
11756152	0	CD30	0,4	L540	116,120	CD30	IL-4	943	3565	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 .
16733205	0	CD30	20,24	OCT4	0,4	CD30	OCT4	943	5460	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	OCT4 is superior to CD30 in the diagnosis of metastatic embryonal_carcinomas after chemotherapy .
22449230	0	CD30	18,22	PAX5	97,101	CD30	PAX5	943	5079	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Primary cutaneous CD30 positive T-cell lymphoproliferative_disorders with aberrant expression of PAX5 : report of three cases .
9037063	0	CD30	0,4	TRAF2	81,86	CD30	TRAF2	943	7186	Gene	Gene	induction|nummod|START_ENTITY mediated|nsubjpass|induction mediated|nmod|END_ENTITY	CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2 .
22940020	0	CD30	13,17	anaplastic_lymphoma_kinase	20,46	CD30	anaplastic lymphoma kinase	943	238	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Two cases of CD30 + , anaplastic_lymphoma_kinase -LRB- ALK -RRB- - negative anaplastic_large_cell_lymphoma with oral manifestations .
15105813	0	CD30	36,40	c-kit	8,13	CD30	c-kit	943	3815	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	Lack of c-kit -LRB- CD117 -RRB- expression in CD30 + lymphomas and lymphomatoid_papulosis .
9305612	0	CD30	22,26	c-kit	10,15	CD30	c-kit	943	3815	Gene	Gene	JURL-MK1|dep|START_ENTITY JURL-MK1|dep|high high|amod|END_ENTITY	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
9305612	0	CD30	60,64	c-kit	49,54	CD30	c-kit	943	3815	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
21536801	0	CD300F	0,6	MyD88	19,24	CD300F	MyD88	146722	4615	Gene	Gene	blocks|nsubj|START_ENTITY blocks|xcomp|END_ENTITY	CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1 .
22077960	0	CD300a	11,17	CD8	18,21	CD300a	CD8	11314	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripheral CD300a + CD8 + T lymphocytes with a distinct cytotoxic molecular signature increase in pregnant women with chronic chorioamnionitis .
17588661	0	CD300a	4,10	IRp60	12,17	CD300a	IRp60	11314	11314	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The CD300a -LRB- IRp60 -RRB- inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a -LRB- FcgammaRIIa -RRB- mediated signaling .
22043923	0	CD300a	0,6	MyD88	46,51	CD300a	MyD88	11314	4615	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines .
16920917	0	CD300b	45,51	immunoglobulin_receptor	70,93	CD300b	immunoglobulin receptor	124599	80739	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Molecular and functional characterization of CD300b , a new activating immunoglobulin_receptor able to transduce signals through two different pathways .
24380839	0	CD305	20,25	LAIR-1	12,18	CD305	LAIR-1	3903	3903	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of LAIR-1 -LRB- CD305 -RRB- in T cells and monocytes/macrophages in patients with rheumatoid_arthritis .
24415628	0	CD305	32,37	LAIR1	25,30	CD305	LAIR1	3903	3903	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of LAIR1 -LRB- CD305 -RRB- as assessed by flow cytometry in a prospective series of patients with chronic_lymphocytic_leukemia .
16681430	0	CD307	106,111	FcRH5	99,104	CD307	FcRH5	83416	83416	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
16681430	0	CD307	106,111	immunoglobulin_superfamily_receptor_translocation-associated_2	28,90	CD307	immunoglobulin superfamily receptor translocation-associated 2	83416	83416	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
11745696	0	CD30L	87,92	CD27L	94,99	CD30L	CD27L	21949(Tax:10090)	21948(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumour necrosis factor -LRB- TNF -RRB- ligand superfamily co-stimulatory molecules CD30L , CD27L , OX40L , and 4-1BBL in murine hearts with acute_myocarditis caused by Coxsackievirus B3 .
12031769	0	CD30L	86,91	CD27L	79,84	CD30L	CD27L	944	970	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L , CD30L , OX40L and 4-1BBL in the heart of patients with acute_myocarditis and dilated_cardiomyopathy .
11745696	0	CD30L	87,92	OX40L	101,106	CD30L	OX40L	21949(Tax:10090)	22164(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumour necrosis factor -LRB- TNF -RRB- ligand superfamily co-stimulatory molecules CD30L , CD27L , OX40L , and 4-1BBL in murine hearts with acute_myocarditis caused by Coxsackievirus B3 .
12031769	0	CD30L	86,91	OX40L	93,98	CD30L	OX40L	944	7292	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L , CD30L , OX40L and 4-1BBL in the heart of patients with acute_myocarditis and dilated_cardiomyopathy .
20639486	0	CD30_ligand	0,11	CD30	12,16	CD30 ligand	CD30	21949(Tax:10090)	21941(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	CD30_ligand / CD30 plays a critical role in Th17 differentiation in mice .
19087127	0	CD31	0,4	Annexin_V	6,15	CD31	Annexin V	5175	308	Gene	Gene	+|compound|START_ENTITY +|parataxis|microparticles microparticles|nsubj|+ +|compound|END_ENTITY	CD31 + / Annexin_V + microparticles in healthy offsprings of patients with coronary_artery_disease .
21186238	0	CD31	12,16	Annexin_V	18,27	CD31	Annexin V	5175	308	Gene	Gene	+|compound|START_ENTITY +|parataxis|microparticles microparticles|nsubj|+ +|compound|END_ENTITY	Circulating CD31 + / Annexin_V + microparticles correlate with cardiovascular outcomes .
10487846	0	CD31	30,34	CD144	53,58	CD31	CD144	5175	1003	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	Functional roles for PECAM-1 -LRB- CD31 -RRB- and VE-cadherin -LRB- CD144 -RRB- in tube assembly and lumen formation in three-dimensional collagen gels .
26142193	0	CD31	8,12	CD16	34,38	CD31	CD16	5175	2214	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduced CD31 expression on CD14 -LRB- + -RRB- CD16 -LRB- + -RRB- monocyte subset in acute_coronary_syndromes .
15947249	0	CD31	0,4	CD31	14,18	CD31	CD31	5175	5175	Gene	Gene	START_ENTITY|parataxis|+ +|nsubj|END_ENTITY	CD31 - but Not CD31 + cardiac side population cells exhibit functional cardiomyogenic differentiation .
15947249	0	CD31	14,18	CD31	0,4	CD31	CD31	5175	5175	Gene	Gene	+|nsubj|START_ENTITY END_ENTITY|parataxis|+	CD31 - but Not CD31 + cardiac side population cells exhibit functional cardiomyogenic differentiation .
14977470	0	CD31	89,93	CD34	95,99	CD31	CD34	5175	947	Gene	Gene	+|dep|START_ENTITY +|dep|END_ENTITY	Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1 + / CD31 - / CD34 - Progenitors .
12673718	0	CD31	44,48	CD38	60,64	CD31	CD38	5175	952	Gene	Gene	expression|nmod|START_ENTITY relevance|nmod|expression ligand|nsubj|relevance ligand|nmod|END_ENTITY	Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B-cell_chronic_lymphocytic_leukemia .
26407101	0	CD31	76,80	CD38	8,12	CD31	CD38	5175	952	Gene	Gene	Enhances|nmod|START_ENTITY Enhances|nsubj|END_ENTITY	Seminal CD38 Enhances Human Sperm Capacitation through Its Interaction with CD31 .
9551996	0	CD31	58,62	CD38	6,10	CD31	CD38	5175	952	Gene	Gene	counter-receptor|nmod|START_ENTITY counter-receptor|nsubj|END_ENTITY	Human CD38 -LRB- ADP-ribosyl cyclase -RRB- is a counter-receptor of CD31 , an Ig superfamily member .
12714245	0	CD31	29,33	CD4	47,50	CD31	CD4	5175	920	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Changes in the expression of CD31 and CXCR3 in CD4 + na ve T cells in elderly persons .
1345920	0	CD31	0,4	CD4	38,41	CD31	CD4	5175	920	Gene	Gene	START_ENTITY|appos|marker marker|nmod|cells cells|nummod|END_ENTITY	CD31 , a novel cell surface marker for CD4 cells of suppressor lineage , unaltered by state of activation .
18448620	0	CD31	94,98	CD4	119,122	CD31	CD4	5175	920	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|cells cells|compound|END_ENTITY	Effects of delays in peripheral blood processing , including cryopreservation , on detection of CD31 expression on naive CD4 T cells .
18583570	0	CD31	23,27	CD4	51,54	CD31	CD4	5175	920	Gene	Gene	+|compound|START_ENTITY Life|dep|+ Life|dep|T-cell T-cell|compound|END_ENTITY	Life after the thymus : CD31 + and CD31 - human naive CD4 + T-cell subsets .
19008454	0	CD31	14,18	CD4	45,48	CD31	CD4	5175	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-7 sustains CD31 expression in human naive CD4 + T cells and preferentially expands the CD31 + subset in a PI3K-dependent manner .
19646767	0	CD31	98,102	CD4	77,80	CD31	CD4	5175	920	Gene	Gene	T-cells|compound|START_ENTITY function|nmod|T-cells function|nmod|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	Glatiramer_acetate improves regulatory T-cell function by expansion of naive CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- CD31 -LRB- + -RRB- T-cells in patients with multiple_sclerosis .
20065992	0	CD31	0,4	CD4	60,63	CD31	CD4	5175	920	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|emigrants emigrants|nmod|T-cells T-cells|compound|END_ENTITY	CD31 -LRB- PECAM-1 -RRB- is a marker of recent thymic emigrants among CD4 + T-cells , but not CD8 + T-cells or gammadelta T-cells , in HIV patients responding to ART .
21734076	0	CD31	0,4	CD4	20,23	CD31	CD4	18613(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|cells cells|compound|END_ENTITY	CD31 is required on CD4 + T cells to promote T cell survival during Salmonella_infection .
8394793	1	CD31	76,80	CD4	108,111	CD31	CD4	5175	920	Gene	Gene	markers|appos|START_ENTITY markers|acl:relcl|help help|xcomp|define define|dobj|subsets subsets|nummod|END_ENTITY	Human naive and memory T cells revisited : new markers -LRB- CD31 and CD27 -RRB- that help define CD4 + T cell subsets .
8707335	0	CD31	0,4	CD4	62,65	CD31	CD4	5175	920	Gene	Gene	antigen|nsubj|START_ENTITY antigen|acl|lost lost|nmod|maturation maturation|compound|END_ENTITY	CD31 -LRB- PECAM-1 -RRB- is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells .
24425872	0	CD31	82,86	CD44	0,4	CD31	CD44	18613(Tax:10090)	12505(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression .
23922300	0	CD31	26,30	CD45	20,24	CD31	CD45	5175	5788	Gene	Gene	+|compound|START_ENTITY +|dep|+ Characterization|dep|+ Characterization|nmod|END_ENTITY	Characterization of CD45 - / CD31 + / CD105 + circulating cells in the peripheral blood of patients with gynecologic malignancies .
23922300	6	CD31	1536,1540	CD45	1528,1532	CD31	CD45	5175	5788	Gene	Gene	uniformly|nmod:npmod|START_ENTITY expressed|advmod|uniformly expressed|nsubj|END_ENTITY	Furthermore , CD45 -LRB- - -RRB- / CD31 -LRB- + -RRB- / CD105 -LRB- + -RRB- cells uniformly expressed the monocyte-specific markers CD14 and CD68 .
23974360	0	CD31	26,30	CD45	20,24	CD31	CD45	18613(Tax:10090)	19264(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|+ +|dep|+ +|compound|END_ENTITY	Injection of Sca-1 + / CD45 + / CD31 + mouse bone mesenchymal stromal-like cells improves cardiac function in a mouse myocardial_infarct model .
24590887	0	CD31	12,16	CD45	6,10	CD31	CD45	5175	5788	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	About CD45 - / CD31 + / CD105 + circulating cells in patients with gynecologic malignancies -- response .
25232467	7	CD31	1122,1126	CD45	1104,1108	CD31	CD45	5175	5788	Gene	Gene	CD146|amod|START_ENTITY END_ENTITY|dobj|CD146	In five out of seven donors , telomeres in candidate native UC MSCs -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- + -RRB- -RRB- were longer compared to donor-matched CD146 -LRB- - -RRB- population -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- - -RRB- -RRB- .
25243061	7	CD31	1122,1126	CD45	1104,1108	CD31	CD45	5175	5788	Gene	Gene	CD146|amod|START_ENTITY END_ENTITY|dobj|CD146	In three out of four donors , telomeres in candidate native UC MSCs -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- + -RRB- -RRB- were longer compared to donor-matched CD146 -LRB- - -RRB- population -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- - -RRB- -RRB- .
11091638	0	CD31	31,35	CD9	8,11	CD31	CD9	5175	928	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nmod|Expression	Loss of CD9 with Expression of CD31 and VEGF in Breast_Carcinoma , as Predictive Factors of Lymph Node Metastasis .
14977470	0	CD31	89,93	Flk1	83,87	CD31	Flk1	5175	3791	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1 + / CD31 - / CD34 - Progenitors .
17360037	0	CD31	51,55	Flk1	44,48	CD31	Flk1	5175	3791	Gene	Gene	CD34|amod|START_ENTITY CD34|amod|END_ENTITY	Impairment in immuno-modulatory function of Flk1 -LRB- + -RRB- CD31 -LRB- - -RRB- CD34 -LRB- - -RRB- MSCs from MDS-RA patients .
10213905	0	CD31	23,27	PECAM-1	14,21	CD31	PECAM-1	5175	5175	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Modulation of PECAM-1 -LRB- CD31 -RRB- expression in human endothelial cells : effect of IFNgamma and IL-10 .
17510564	0	CD31	14,18	PECAM-1	20,27	CD31	PECAM-1	5175	5175	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Evaluation of CD31 -LRB- PECAM-1 -RRB- expression using tissue microarray in patients with renal_cell_carcinoma .
18523558	0	CD31	26,30	PECAM-1	17,24	CD31	PECAM-1	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for PECAM-1 -LRB- CD31 -RRB- in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow .
9284815	0	CD31	35,39	PECAM-1	27,34	CD31	PECAM-1	29583(Tax:10116)	29583(Tax:10116)	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of endothelial PECAM-1 / CD31 in angiogenesis .
9575861	0	CD31	17,21	PECAM-1	8,15	CD31	PECAM-1	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of PECAM-1 -LRB- CD31 -RRB- in neutrophil transmigration in murine models of liver_and_peritoneal_inflammation .
12451264	0	CD31	47,51	Platelet-endothelial_cell_adhesion_molecule-1	0,45	CD31	Platelet-endothelial cell adhesion molecule-1	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Platelet-endothelial_cell_adhesion_molecule-1 -LRB- CD31 -RRB- expression on donor endothelial cells attenuates the development of transplant_arteriosclerosis .
21615679	0	CD31	113,117	SCA1	107,111	CD31	SCA1	18613(Tax:10090)	20238(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	In vitro and in vivo proliferation , differentiation and migration of cardiac endothelial progenitor cells -LRB- SCA1 + / CD31 + side-population cells -RRB- .
24919180	0	CD31	75,79	Sca-1	68,73	CD31	Sca-1	18613(Tax:10090)	20238(Tax:10090)	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	Intra-myocardial injection of both growth factors and heart derived Sca-1 + / CD31 - cells attenuates post-MI LV remodeling more than does cell transplantation alone : neither intervention enhances functionally significant cardiomyocyte regeneration .
19254813	0	CD31	39,43	Sca1	33,37	CD31	Sca1	18613(Tax:10090)	110454(Tax:10090)	Gene	Gene	Differentiation|dep|START_ENTITY Differentiation|nmod|+ +|amod|END_ENTITY	Differentiation and migration of Sca1 + / CD31 - cardiac side population cells in a murine myocardial_ischemic model .
16239600	0	CD31	12,16	annexin_V	18,27	CD31	annexin V	5175	308	Gene	Gene	+|compound|START_ENTITY +|parataxis|correlate correlate|nsubj|microparticles microparticles|amod|END_ENTITY	Circulating CD31 + / annexin_V + apoptotic microparticles correlate with coronary endothelial function in patients with coronary_artery_disease .
20520578	0	CD31	22,26	annexin_V	28,37	CD31	annexin V	5175	308	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	Increased circulating CD31 + / annexin_V + apoptotic microparticles and decreased circulating endothelial progenitor cell levels in hypertensive patients with microalbuminuria .
9232450	0	CD31	106,110	interferon-gamma	70,86	CD31	interferon-gamma	5175	3458	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	CD45RA-expressing memory/effector Th cells committed to production of interferon-gamma lack expression of CD31 .
11277413	0	CD31	114,118	p53	120,123	CD31	p53	5175	7157	Gene	Gene	Mib-1|compound|START_ENTITY Mib-1|dep|END_ENTITY	Oligodendroglioma : HMB-45 positivity using catalyzed signal amplification method : an immunohistochemical -LRB- HMB-45 , CD31 , p53 , Mib-1 -RRB- and ultrastructural study .
15786495	0	CD31	77,81	platelet_endothelial_cell_adhesion_molecule-1	22,67	CD31	platelet endothelial cell adhesion molecule-1	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Kinetic expression of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 / CD31 -RRB- during embryonic_stem cell differentiation .
17785435	0	CD316	6,11	HSPA8	40,45	CD316	HSPA8	93185	3312	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	EWI-2 / CD316 is an inducible receptor of HSPA8 on human dendritic cells .
21899113	0	CD32	45,49	CD40	50,54	CD32	CD40	2212	958	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The determination of content of circulating CD32 + CD40 + micro particles : the modification of method of assessment of destruction of endothelial cells -RSB- .
16606986	0	CD32	37,41	FCgamma_receptor_IIA	15,35	CD32	FCgamma receptor IIA	2212	2212	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of FCgamma_receptor_IIA -LRB- CD32 -RRB- polymorphism with malarial_anemia and high-density parasitemia in infants and young children .
24594077	0	CD32	43,47	Fc-gamma_receptor_IIa	20,41	CD32	Fc-gamma receptor IIa	2212	2212	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between Fc-gamma_receptor_IIa -LRB- CD32 -RRB- gene polymorphism and malaria susceptibility : a meta-analysis based on 6928 subjects .
9798027	0	CD32	36,40	Fc_gamma_RIIa	21,34	CD32	Fc gamma RIIa	2212	2212	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of human Fc_gamma_RIIa -LRB- CD32 -RRB- polymorphism with susceptibility to and severity of meningococcal_disease .
11719384	0	CD32	39,43	FcgammaRIIA	26,37	CD32	FcgammaRIIA	2212	2212	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The cytoplasmic domain of FcgammaRIIA -LRB- CD32 -RRB- participates in phagolysosome formation .
15604023	0	CD32	46,50	FcgammaRIIa	33,44	CD32	FcgammaRIIa	2212	2212	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Flow cytometric determination of FcgammaRIIa -LRB- CD32 -RRB- polymorphism .
11398118	0	CD32	22,26	Fcgamma_receptor_IIa	0,20	CD32	Fcgamma receptor IIa	2212	2212	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Fcgamma_receptor_IIa -LRB- CD32 -RRB- polymorphism is associated with protection of infants against high-density Plasmodium_falciparum infection .
14740869	0	CD32	37,41	Fcgamma_receptor_IIa	15,35	CD32	Fcgamma receptor IIa	2212	2212	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of Fcgamma_receptor_IIa -LRB- CD32 -RRB- polymorphism with severe malaria in West Africa .
7543071	0	CD32	75,79	Granulocyte_colony-stimulating_factor	0,37	CD32	Granulocyte colony-stimulating factor	2212	1440	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- administration increases PMN CD32 -LRB- FcRII -RRB- expression and FcR-related functions .
7577649	0	CD32A	58,63	Fc_gamma_RIIA	43,56	CD32A	Fc gamma RIIA	2212	2212	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Quantitation of soluble and membrane-bound Fc_gamma_RIIA -LRB- CD32A -RRB- mRNA in platelets and megakaryoblastic cell line -LRB- Meg-01 -RRB- .
14613290	0	CD32B	50,55	Fcgamma_receptor_IIB	28,48	CD32B	Fcgamma receptor IIB	2213	2213	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	A novel polymorphism in the Fcgamma_receptor_IIB -LRB- CD32B -RRB- transmembrane region alters receptor signaling .
16682172	0	CD32a	78,83	Src_homology_2-containing_inositol_5-phosphatase_1	4,54	CD32a	Src homology 2-containing inositol 5-phosphatase 1	2212	3635	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The Src_homology_2-containing_inositol_5-phosphatase_1 -LRB- SHIP1 -RRB- is involved in CD32a signaling in human neutrophils .
1379402	0	CD33	6,10	CD13	13,17	CD33	CD13	945	290	Gene	Gene	CD4|nummod|START_ENTITY CD4|dep|END_ENTITY	CD4 + , CD33 - , CD13 - , CD14 - acute_monoblastic_leukaemia .
17339183	0	CD33	44,48	CD13	32,36	CD33	CD13	945	290	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Absence of prognostic impact of CD13 and/or CD33 antigen expression in adult acute_lymphoblastic_leukemia .
8659452	0	CD33	36,40	CD13	17,21	CD33	CD13	945	290	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Myeloid antigen , CD13 , CD14 , and/or CD33 expression is restricted to certain lymphoid_neoplasms .
9335320	0	CD33	27,31	CD13	22,26	CD33	CD13	945	290	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expansion of CD13 + CD33 + dendritic cell precursors from multipotent progenitors is regulated by a discrete fas-mediated apoptotic schedule .
1379402	0	CD33	6,10	CD14	20,24	CD33	CD14	945	929	Gene	Gene	CD4|nummod|START_ENTITY CD4|dep|CD13 CD13|parataxis|END_ENTITY	CD4 + , CD33 - , CD13 - , CD14 - acute_monoblastic_leukaemia .
19572148	0	CD33	105,109	CD14	91,95	CD33	CD14	945	929	Gene	Gene	cells|nummod|START_ENTITY lymphocytes|nsubj|cells +|parataxis|lymphocytes +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
23904440	0	CD33	5,9	CD14	0,4	CD33	CD14	945	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD14 + CD33 + myeloid cell-CCL11-eosinophil signature in ulcerative_colitis .
24495013	0	CD33	34,38	CD14	42,46	CD33	CD14	945	929	Gene	Gene	frequencies|nmod|START_ENTITY myeloid-derived|nsubj|frequencies myeloid-derived|nsubj|HLA-DR HLA-DR|compound|END_ENTITY	Increased frequencies of CD11b -LRB- + -RRB- CD33 -LRB- + -RRB- CD14 -LRB- + -RRB- HLA-DR -LRB- low -RRB- myeloid-derived suppressor cells are an early event in melanoma patients .
8659452	0	CD33	36,40	CD14	23,27	CD33	CD14	945	929	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Myeloid antigen , CD13 , CD14 , and/or CD33 expression is restricted to certain lymphoid_neoplasms .
19572148	0	CD33	105,109	CD15	99,103	CD33	CD15	945	2526	Gene	Gene	cells|nummod|START_ENTITY lymphocytes|nsubj|cells +|parataxis|lymphocytes +|compound|END_ENTITY	Population alterations of L-arginase - and inducible nitric_oxide synthase-expressed CD11b + / CD14 / CD15 + / CD33 + myeloid-derived suppressor cells and CD8 + T lymphocytes in patients with advanced-stage non-small_cell_lung_cancer .
7517211	0	CD33	9,13	CD16	23,27	CD33	CD16	945	2214	Gene	Gene	+|compound|START_ENTITY -|appos|+ -|appos|END_ENTITY	HLA-DR - , CD33 + , CD56 + , CD16 - myeloid/natural killer cell acute_leukemia : a previously unrecognized form of acute_leukemia potentially misdiagnosed as French-American-British acute_myeloid_leukemia-M3 .
19259613	0	CD33	73,77	CD33	92,96	CD33	CD33	945	945	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33 + myeloma cells .
19259613	0	CD33	92,96	CD33	73,77	CD33	CD33	945	945	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33 + myeloma cells .
11940478	0	CD33	34,38	CD34	20,24	CD33	CD34	945	947	Gene	Gene	CD13|nummod|START_ENTITY +|appos|CD13 +|compound|END_ENTITY	Characterization of CD34 + , CD13 + , CD33 - cells , a rare subset of immature human hematopoietic cells .
12063025	0	CD33	87,91	CD34	129,133	CD33	CD34	945	947	Gene	Gene	CD38|compound|START_ENTITY enriched|nmod|CD38 fraction|amod|enriched fraction|nmod|cells cells|compound|END_ENTITY	Myeloid-lymphoid initiating cells -LRB- ML-IC -RRB- are highly enriched in the rhodamine-c-kit -LRB- + -RRB- CD33 -LRB- - -RRB- CD38 -LRB- - -RRB- fraction of umbilical cord CD34 -LRB- + -RRB- cells .
16809615	0	CD33	42,46	CD34	36,40	CD33	CD34	945	947	Gene	Gene	precursors|dep|START_ENTITY precursors|compound|END_ENTITY	FLT3 internal tandem duplication in CD34 + / CD33 - precursors predicts poor outcome in acute_myeloid_leukemia .
1716590	0	CD33	133,137	CD34	139,143	CD33	CD34	945	947	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Blast colony-forming_cells and precursors of colony-forming_cells detectable in long-term marrow culture express the same phenotype -LRB- CD33 - CD34 + -RRB- .
17181570	0	CD33	34,38	CD34	42,46	CD33	CD34	945	947	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|+ +|compound|END_ENTITY	Expression of the target receptor CD33 in CD34 + / CD38 - / CD123 + AML stem cells .
17453971	0	CD33	129,133	CD34	36,40	CD33	CD34	945	947	Gene	Gene	express|dobj|START_ENTITY lack|ccomp|express lack|nsubj|progenitors progenitors|nmod|patients patients|amod|END_ENTITY	Primitive AML progenitors from most CD34 -LRB- + -RRB- patients lack CD33 expression but progenitors from many CD34 -LRB- - -RRB- AML patients express CD33 .
17453971	0	CD33	58,62	CD34	36,40	CD33	CD34	945	947	Gene	Gene	expression|nummod|START_ENTITY patients|compound|expression express|nsubj|patients lack|ccomp|express lack|nsubj|progenitors progenitors|nmod|patients patients|amod|END_ENTITY	Primitive AML progenitors from most CD34 -LRB- + -RRB- patients lack CD33 expression but progenitors from many CD34 -LRB- - -RRB- AML patients express CD33 .
21729522	0	CD33	81,85	CD34	89,93	CD33	CD34	945	947	Gene	Gene	/|compound|START_ENTITY surface|nmod|/ binding|nmod|surface cells|amod|binding cells|compound|END_ENTITY	-LSB- Screening and structure analysis of nucleic acid aptamers binding to surface of CD33 -LRB- + -RRB- / CD34 -LRB- + -RRB- cells from patients with acute_myeloid_leukemia subtype M -RSB- .
21993666	0	CD33	73,77	CD34	0,4	CD33	CD34	945	947	Gene	Gene	Siglec-3|appos|START_ENTITY cells|nmod|Siglec-3 stem|dobj|cells stem|nsubj|END_ENTITY	CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- stem cells in chronic_myeloid_leukemia express Siglec-3 -LRB- CD33 -RRB- and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin .
7496354	0	CD33	6,10	CD34	0,4	CD33	CD34	945	947	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	CD34 + / CD33 + blast cells : correlation with FAB subtypes .
7514903	0	CD33	14,18	CD34	40,44	CD33	CD34	945	947	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD33 , CD38 , and HLA-DR on CD34 + human fetal liver progenitors with a high proliferative potential .
7533867	0	CD33	139,143	CD34	75,79	CD33	CD34	945	947	Gene	Gene	+|compound|START_ENTITY phenotype|appos|+ isolated|nmod|phenotype isolated|nmod|fraction fraction|amod|+ +|compound|END_ENTITY	Residual normal , highly proliferative progenitors can be isolated from the CD34 + / 33 - fraction of AML with a more differentiated phenotype -LRB- CD33 + -RRB- .
7687219	6	CD33	1024,1028	CD34	1019,1023	CD33	CD34	945	947	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Using this procedure , we carried out an analysis of c-kit mRNA expression in CD34 + CD33 - , CD34 + CD33 + , CD34-CD33 + , and CD34-CD33 - cells .
9091301	0	CD33	113,117	CD34	18,22	CD33	CD34	945	947	Gene	Gene	coexpression|nummod|START_ENTITY irrespective|nmod:npmod|coexpression myeloperoxidase-negative|advmod|irrespective myeloperoxidase-negative|nsubj|progenitors progenitors|compound|END_ENTITY	RhG-CSF-mobilized CD34 + peripheral blood progenitors are myeloperoxidase-negative and noncycling irrespective of CD33 or CD13 coexpression .
9733270	0	CD33	24,28	CD34	18,22	CD33	CD34	945	947	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	The importance of CD34 + / CD33 - cells in platelet engraftment after intensive therapy for cancer patients given peripheral blood stem cell rescue .
21993666	0	CD33	73,77	CD38	8,12	CD33	CD38	945	952	Gene	Gene	Siglec-3|appos|START_ENTITY cells|nmod|Siglec-3 stem|dobj|cells stem|nsubj|END_ENTITY	CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- stem cells in chronic_myeloid_leukemia express Siglec-3 -LRB- CD33 -RRB- and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin .
10391105	2	CD33	376,380	CD56	385,389	CD13	CD33	290	945	Gene	Gene	+|appos|START_ENTITY +|appos|END_ENTITY	We describe the morphological , cytochemical , immunologic , and cytogenetic features of two patients with AML with maturation -LRB- FAB_M2 -RRB- and the phenotype MPO + , CD13 _ -LRB- - -RRB- , CD33 -LRB- - -RRB- , CD56 -LRB- + -RRB- .
25892023	0	CD33	62,66	Siglec-3	53,61	CD33	Siglec-3	945	945	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Molecular and functional characterization of porcine Siglec-3 / CD33 and analysis of its expression in blood and tissues .
25059667	0	CD33	172,176	Toll-like_receptor-4	23,43	CD33	Toll-like receptor-4	945	7099	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of Toll-like_receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein , CD14 , with the sialic_acid-binding lectin , CD33 .
19135771	0	CD34	53,57	ABL1	32,36	CD34	ABL1	947	25	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of P190 and P210_BCR / ABL1 in normal human CD34 -LRB- + -RRB- cells induces similar gene expression profiles and results in a STAT5-dependent expansion of the erythroid lineage .
10456440	0	CD34	18,22	AC133	24,29	CD34	AC133	947	8842	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Ex vivo expansion CD34 + / AC133 + - selected autologous peripheral blood progenitor cells -LRB- PBPC -RRB- in high-risk breast_cancer patients receiving intensive chemotherapy .
10580405	0	CD34	69,73	AC133	74,79	CD34	AC133	947	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Human_immunodeficiency_virus_infection of human placental cord blood CD34 + AC133 + stem cells and their progeny .
10985471	0	CD34	73,77	AC133	66,71	CD34	AC133	947	8842	Gene	Gene	cells|compound|START_ENTITY selected|nsubj|cells differentiation|parataxis|selected differentiation|nmod|+ +|compound|END_ENTITY	Myeloid differentiation and maturation of SCF+IL -3 + IL-11 expanded AC133 + / CD34 + cells selected from high-risk breast_cancer patients .
11177594	0	CD34	159,163	AC133	124,129	CD34	AC133	947	8842	Gene	Gene	+|compound|START_ENTITY hierarchy|dep|+ hierarchy|nmod|cells cells|acl|based based|nmod|potential potential|nmod|CD34 CD34|compound|END_ENTITY	A functional hierarchy among the CD34 + hematopoietic cells based on in vitro proliferative and differentiative potential of AC133 + CD34 -LRB- bright -RRB- and AC133 -LRB- dim / -RRB- - CD34 + human cord blood cells .
11177594	0	CD34	33,37	AC133	124,129	CD34	AC133	947	8842	Gene	Gene	cells|nummod|START_ENTITY cells|acl|based based|nmod|potential potential|nmod|CD34 CD34|compound|END_ENTITY	A functional hierarchy among the CD34 + hematopoietic cells based on in vitro proliferative and differentiative potential of AC133 + CD34 -LRB- bright -RRB- and AC133 -LRB- dim / -RRB- - CD34 + human cord blood cells .
12002675	0	CD34	96,100	AC133	89,94	CD34	AC133	947	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
17588480	0	CD34	6,10	AC133	11,16	CD34	AC133	947	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD34 + AC133 + VEGFR-2 + cells are not endothelial progenitor cells but distinct , primitive hematopoietic progenitors .
19948206	0	CD34	29,33	B7-H1	40,45	CD34	B7-H1	947	29126	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A subpopulation of malignant CD34 + CD138 + B7-H1 + plasma cells is present in multiple_myeloma patients .
15345592	0	CD34	41,45	BCR-ABL	13,20	CD34	BCR-ABL	947	25	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Detection of BCR-ABL kinase mutations in CD34 + cells from chronic_myelogenous_leukemia patients in complete cytogenetic remission on imatinib_mesylate treatment .
19556423	0	CD34	48,52	BMI1	14,18	CD34	BMI1	947	648	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Repression of BMI1 in normal and leukemic human CD34 -LRB- + -RRB- cells impairs self-renewal and induces apoptosis .
20724541	0	CD34	67,71	BMI1	0,4	CD34	BMI1	947	648	Gene	Gene	cells|compound|START_ENTITY transformation|nmod|cells BCR-ABL|nmod|transformation collaborates|advcl|BCR-ABL collaborates|nsubj|END_ENTITY	BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34 + cells .
10456672	0	CD34	124,128	Bcl-2	91,96	CD34	Bcl-2	947	596	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Effect of all-trans_retinoic_acid on chemotherapy induced apoptosis and down-regulation of Bcl-2 in human myeloid_leukaemia CD34 positive cells .
11380462	0	CD34	34,38	Bcl-2	0,5	CD34	Bcl-2	947	596	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Bcl-2 and Bcl-x expression in the CD34 + cells of aplastic_anaemia patients : relationship with increased apoptosis and upregulation of Fas_antigen .
11532351	0	CD34	56,60	Bcl-2	94,99	CD34	Bcl-2	947	596	Gene	Gene	CD38|compound|START_ENTITY apoptosis|nmod|CD38 apoptosis|dep|cells cells|acl:relcl|express express|dobj|END_ENTITY	Transforming_growth_factor-beta -LRB- 1 -RRB- induces apoptosis in CD34 -LRB- + -RRB- CD38 -LRB- - / low -RRB- cells that express Bcl-2 at a low level .
21595920	0	CD34	87,91	Bcl-2	31,36	CD34	Bcl-2	947	596	Gene	Gene	lines|compound|START_ENTITY apoptosis|nmod|lines leading|nmod|apoptosis reduces|advcl|leading reduces|dobj|expression expression|nmod|END_ENTITY	Curcumin reduces expression of Bcl-2 , leading to apoptosis in daunorubicin-insensitive CD34 + acute_myeloid_leukemia cell lines and primary sorted CD34 + acute_myeloid_leukemia cells .
21894749	0	CD34	57,61	Bcl-2	18,23	CD34	Bcl-2	947	596	Gene	Gene	cells|nummod|START_ENTITY study|nmod|cells study|nmod|p53 p53|compound|END_ENTITY	-LSB- Dynamic study of Bcl-2 , Bax , p53 , and ACE expression in CD34 + cells of peripheral blood and bone marrow in acute_leukemia patients in the course of induction chemotherapy -RSB- .
26431162	0	CD34	112,116	Bcl-2	92,97	CD34	Bcl-2	947	596	Gene	Gene	proliferating|compound|START_ENTITY inhibition|nmod|proliferating inhibition|nmod|inhibition inhibition|nmod|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
26960457	0	CD34	24,28	Bcl-2	30,35	CD34	Bcl-2	947	596	Gene	Gene	Ki-67|appos|START_ENTITY Ki-67|appos|END_ENTITY	The role of Ki-67 , p16 , CD34 , Bcl-2 , cyclooxygenase-2 in the pathogenesis of proliferative_verrucous_leukoplakia .
8839847	0	CD34	72,76	Bcl-2	25,30	CD34	Bcl-2	947	596	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Interleukin-10 increases Bcl-2 expression and survival in primary human CD34 + hematopoietic progenitor cells .
24834842	0	CD34	18,22	C-kit	26,31	CD34	C-kit	947	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	The Expression of CD34 -LRB- + -RRB- / C-kit -LRB- + -RRB- Stem Cells in Peripheral Blood in Infants After Deep_Hypothermia_Circulatory Arrest .
12406909	0	CD34	85,89	C/EBPalpha	13,23	CD34	C/EBPalpha	947	1050	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells alters|dobj|expression alters|nsubj|Induction Induction|nmod|activity activity|compound|END_ENTITY	Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34 + cells .
17475913	0	CD34	41,45	C/EBPalpha	18,28	CD34	C/EBPalpha	947	1050	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Reintroduction of C/EBPalpha in leukemic CD34 + stem/progenitor cells impairs self-renewal and partially restores myelopoiesis .
12871220	0	CD34	82,86	CC_chemokine_receptor_3	32,55	CD34	CC chemokine receptor 3	947	1232	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Allergen-induced fluctuation in CC_chemokine_receptor_3 expression on bone marrow CD34 + cells from asthmatic subjects : significance for mobilization of haemopoietic progenitor cells in allergic_inflammation .
24492332	0	CD34	24,28	CD10	18,22	CD34	CD10	947	4311	Gene	Gene	CD117|dep|START_ENTITY CD117|dep|END_ENTITY	Utility of Ki-67 , CD10 , CD34 , p53 , CD117 , and mast cell content in the differential diagnosis of cellular fibroadenomas and in the classification of phyllodes tumors of the breast .
9477126	0	CD34	41,45	CD10	31,35	CD34	CD10	947	4311	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Prognostic significance of the CD10 + CD19 + CD34 + B-progenitor immunophenotype in children with acute_lymphoblastic_leukemia : a report from the Children 's Cancer Group .
17704793	0	CD34	39,43	CD110	45,50	CD34	CD110	947	4352	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Failure to achieve a threshold dose of CD34 + CD110 + progenitor cells in the graft predicts delayed platelet engraftment after autologous stem cell transplantation .
19822297	0	CD34	39,43	CD110	44,49	CD34	CD110	947	4352	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Failure to achieve a threshold dose of CD34 + CD110 + progenitor cells in the graft predicts delayed platelet engraftment after autologous stem_cell_transplantation for multiple_myeloma .
16267071	0	CD34	16,20	CD117	25,30	CD34	CD117	947	3815	Gene	Gene	Mobilization|nmod|START_ENTITY Mobilization|appos|END_ENTITY	Mobilization of CD34 -LRB- + -RRB- , CD117 -LRB- + -RRB- , CXCR4 -LRB- + -RRB- , c-met -LRB- + -RRB- stem cells is correlated with left_ventricular_ejection_fraction and plasma NT-proBNP levels in patients with acute_myocardial_infarction .
24577437	0	CD34	28,32	CD117	0,5	CD34	CD117	947	3815	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ expression|nmod|cells expression|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
25045527	0	CD34	46,50	CD117	52,57	CD34	CD117	947	3815	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	Recruitment and retention of human autologous CD34 + CD117 + CD133 + bone marrow stem cells to infarcted_myocardium followed by directed vasculogenesis : Novel strategy for cardiac regeneration .
18415658	0	CD34	30,34	CD123	42,47	CD34	CD123	947	3563	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	HERG K + channel expression in CD34 + / CD38 - / CD123 -LRB- high -RRB- cells and primary leukemia cells and analysis of its regulation in leukemia cells .
21933861	0	CD34	15,19	CD123	29,34	CD34	CD123	947	3563	Gene	Gene	/|compound|START_ENTITY /|dep|blasts blasts|nummod|+ +|compound|END_ENTITY	High levels of CD34 + CD38low / - CD123 + blasts are predictive of an adverse outcome in acute_myeloid_leukemia : a Groupe Ouest-Est des Leucemies Aigues et Maladies du Sang -LRB- GOELAMS -RRB- study .
24598641	0	CD34	1,5	CD123	27,32	CD34	CD123	947	3563	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|overexpression overexpression|compound|END_ENTITY	-LSB- CD34 -LRB- + -RRB- CD19 -LRB- + -RRB- cells with CD123 overexpression are a novel prognostic marker in Ph chromosome-positive acute_lymphoblastic_leukemia -RSB- .
24846193	0	CD34	10,14	CD123	21,26	CD34	CD123	947	3563	Gene	Gene	CD38|compound|START_ENTITY CD38|dep|cells cells|nummod|END_ENTITY	Increased CD34 + CD38 - CD123 + cells in myelodysplastic_syndrome displaying malignant features similar to those in AML .
10498605	0	CD34	84,88	CD13	135,139	CD34	CD13	947	290	Gene	Gene	population|acl:relcl|START_ENTITY arise|nmod|population Demonstration|dep|arise aminopeptidase|nsubj|Demonstration aminopeptidase|dobj|END_ENTITY	Demonstration that human mast cells arise from a progenitor cell population that is CD34 -LRB- + -RRB- , c-kit -LRB- + -RRB- , and expresses aminopeptidase N -LRB- CD13 -RRB- .
11940478	0	CD34	20,24	CD13	27,31	CD34	CD13	947	290	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Characterization of CD34 + , CD13 + , CD33 - cells , a rare subset of immature human hematopoietic cells .
20489139	0	CD34	8,12	CD13	13,17	CD34	CD13	12490(Tax:10090)	16790(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Myeloid CD34 + CD13 + precursor cells transdifferentiate into chondrocyte-like cells in atherosclerotic intimal calcification .
11359674	0	CD34	43,47	CD133	0,5	CD34	CD133	947	8842	Gene	Gene	selection|compound|START_ENTITY alternative|nmod|selection expansion|amod|alternative expansion|nsubj|selection selection|nummod|END_ENTITY	CD133 + cell selection is an alternative to CD34 + cell selection for ex vivo expansion of hematopoietic stem cells .
15910245	0	CD34	42,46	CD133	48,53	CD34	CD133	947	8842	Gene	Gene	hematopoietic|compound|START_ENTITY hematopoietic|compound|END_ENTITY	Differential gene expression profiling of CD34 + CD133 + umbilical cord blood hematopoietic stem progenitor cells .
16110028	0	CD34	12,16	CD133	19,24	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Circulating CD34 + , CD133 + , and vascular_endothelial_growth_factor_receptor_2-positive endothelial progenitor cells in myelofibrosis_with_myeloid_metaplasia .
16439688	0	CD34	0,4	CD133	6,11	CD34	CD133	947	8842	Gene	Gene	START_ENTITY|parataxis|+ +|compound|END_ENTITY	CD34 - / CD133 + / VEGFR-2 + endothelial progenitor cell subpopulation with potent vasoregenerative capacities .
16698211	0	CD34	0,4	CD133	6,11	CD34	CD133	305081(Tax:10116)	60357(Tax:10116)	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	CD34 + / CD133 - circulating endothelial precursor cells -LRB- CEP -RRB- : characterization , senescence and in vivo application .
17492259	0	CD34	7,11	CD133	13,18	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	Viable CD34 + / CD133 + blood progenitor cell dose as a predictor of haematopoietic engraftment in multiple_myeloma patients undergoing autologous peripheral blood stem cell transplantation .
17559657	0	CD34	51,55	CD133	44,49	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY progenitor|nsubj|+ pathways|parataxis|progenitor pathways|acl|involved involved|nmod|+ +|compound|END_ENTITY	Common molecular pathways involved in human CD133 + / CD34 + progenitor cell expansion and cancer .
17765649	0	CD34	22,26	CD133	28,33	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
18410526	0	CD34	40,44	CD133	34,39	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells from cord blood CD133 + CD34 + progenitors share phenotypic , functional and gene expression profile similarities with lymphatics .
18811243	0	CD34	54,58	CD133	47,52	CD34	CD133	947	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cord blood-derived neurons are originated from CD133 + / CD34 stem/progenitor cells in a cell-to-cell contact dependent manner .
19024325	0	CD34	83,87	CD133	76,81	CD34	CD133	947	8842	Gene	Gene	immunophenotype|nummod|START_ENTITY immunophenotype|nummod|END_ENTITY	-LSB- Multiparametric flow cytometry analyzes the expressions of immunophenotype CD133 , CD34 , CD44 in lung_cancer naive cells -RSB- .
19380281	0	CD34	23,27	CD133	47,52	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY number|nmod|+ number|dep|cells cells|nummod|END_ENTITY	Differential number of CD34 + , CD133 + and CD34 + / CD133 + cells in peripheral blood of patients with congestive_heart_failure .
19956906	0	CD34	84,88	CD133	90,95	CD34	CD133	947	8842	Gene	Gene	migration|nmod|START_ENTITY enhance|dobj|migration enhance|parataxis|+ +|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_proteins-2_and _ -4 enhance the migration of human CD34 - / CD133 + hematopoietic stem and progenitor cells .
20213459	0	CD34	6,10	CD133	0,5	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD133 + CD34 + stem cells are mobilized after musculoskeletal surgery and target endothelium activated by surgical wound fluid .
21715308	0	CD34	24,28	CD133	44,49	CD34	CD133	947	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adult human circulating CD34 Lin CD45 CD133 cells can differentiate into hematopoietic and endothelial cells .
22386660	0	CD34	6,10	CD133	0,5	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD133 + CD34 + and CD133 + CD38 + blood progenitor cells as predictors of platelet engraftment in patients undergoing autologous peripheral blood stem cell transplantation .
22480576	0	CD34	40,44	CD133	34,39	CD34	CD133	947	8842	Gene	Gene	CD45|compound|START_ENTITY CD45|compound|END_ENTITY	Isolation and characterization of CD133 + CD34 + VEGFR-2 + CD45 - fetal endothelial cells from human term placenta .
22543333	0	CD34	53,57	CD133	46,51	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY stem|nsubj|+ labeling|parataxis|stem labeling|nmod|+ +|compound|END_ENTITY	Clinical labeling and imaging of transplanted CD133 + / CD34 + stem cells in patients with ischemic_heart_disease .
22855739	0	CD34	28,32	CD133	21,26	CD34	CD133	947	8842	Gene	Gene	Osteocalcin|parataxis|START_ENTITY Osteocalcin|dep|positive positive|dep|+ +|compound|END_ENTITY	Osteocalcin positive CD133 + / CD34 - / KDR + progenitor cells as an independent marker for unstable atherosclerosis .
23097560	0	CD34	37,41	CD133	43,48	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY injection|nmod|+ injection|parataxis|increase increase|nsubj|cells cells|compound|END_ENTITY	Intrablastocyst injection with human CD34 + / CD133 + cells increase survival of immunocompetent fumarylacetoacetate_hydrolase knockout mice .
23135476	0	CD34	51,55	CD133	44,49	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY stem|nsubj|+ MicroRNAs|parataxis|stem MicroRNAs|nmod|markers markers|nmod|+ +|compound|END_ENTITY	MicroRNAs as markers for neurally committed CD133 + / CD34 + stem cells derived from human umbilical cord blood .
24335569	0	CD34	74,78	CD133	79,84	CD34	CD133	947	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Inverse correlation between circulating endothelial progenitor cells with CD34 + CD133 + and the severity of coronary_atherosclerosis assessed by Syntax score .
24335569	5	CD34	614,618	CD133	621,626	CD34	CD133	947	8842	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	The percentage of CD34 -LRB- + -RRB- CD133 -LRB- + -RRB- cells in the mononuclear cells isolated from peripheral blood of different groups by flow cytometric analysis was compared .
25045527	0	CD34	46,50	CD133	59,64	CD34	CD133	947	8842	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	Recruitment and retention of human autologous CD34 + CD117 + CD133 + bone marrow stem cells to infarcted_myocardium followed by directed vasculogenesis : Novel strategy for cardiac regeneration .
25444027	0	CD34	19,23	CD133	12,17	CD34	CD133	947	8842	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Circulating CD133 + CD34 + Progenitor Cells and Plasma Stromal-Derived Factor-1Alpha : Predictive Role in Ischemic_Stroke Patients .
27016273	0	CD34	46,50	CD133	29,34	CD34	CD133	947	8842	Gene	Gene	START_ENTITY|nsubj|frequency frequency|nmod|CD45RA CD45RA|compound|END_ENTITY	The frequency of multipotent CD133 -LRB- + -RRB- CD45RA -LRB- - -RRB- CD34 -LRB- + -RRB- hematopoietic stem cells is not increased in fetal liver compared to adult stem cell sources .
10090933	0	CD34	27,31	CD14	146,150	CD34	CD14	947	929	Gene	Gene	progenitors|compound|START_ENTITY culture|nmod|progenitors induces|nsubj|culture induces|dobj|amplification amplification|nmod|END_ENTITY	Long-term culture of human CD34 -LRB- + -RRB- progenitors with FLT3-ligand , thrombopoietin , and stem cell factor induces extensive amplification of a CD34 -LRB- - -RRB- CD14 -LRB- - -RRB- and a CD34 -LRB- - -RRB- CD14 -LRB- + -RRB- dendritic cell precursor .
10528188	0	CD34	0,4	CD14	19,23	CD34	CD14	947	929	Gene	Gene	+|compound|START_ENTITY cell-derived|nsubj|+ cell-derived|ccomp|develop develop|nsubj|cells cells|compound|END_ENTITY	CD34 + cell-derived CD14 + precursor cells develop into Langerhans cells in a TGF-beta_1-dependent manner .
10623814	0	CD34	72,76	CD14	67,71	CD34	CD14	947	929	Gene	Gene	precursors|compound|START_ENTITY precursors|compound|END_ENTITY	uPA/uPAR system is active in immature dendritic cells derived from CD14 + CD34 + precursors and is down-regulated upon maturation .
12393747	0	CD34	84,88	CD14	89,93	CD34	CD14	947	929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Transendothelial migration leads to protection from starvation-induced apoptosis in CD34 + CD14 + circulating precursors : evidence for PECAM-1 involvement through Akt/PKB activation .
15947790	0	CD34	80,84	CD14	94,98	CD34	CD14	947	929	Gene	Gene	+|compound|START_ENTITY plasticity|nmod|+ Correlation|nmod|plasticity Correlation|dep|END_ENTITY	Correlation between differentiation plasticity and mRNA expression profiling of CD34 + - derived CD14 - and CD14 + human normal myeloid precursors .
16959899	0	CD34	2,6	CD14	90,94	CD34	CD14	947	929	Gene	Gene	Langerhans|nsubj|START_ENTITY Langerhans|nsubj|model model|dep|evidence evidence|nmod|CD11b CD11b|compound|END_ENTITY	A CD34 -LRB- + -RRB- human cell line model of myeloid dendritic cell differentiation : evidence for a CD14 -LRB- + -RRB- CD11b -LRB- + -RRB- Langerhans cell precursor .
17595380	0	CD34	102,106	CD14	33,37	CD34	CD14	947	929	Gene	Gene	progenitors|compound|START_ENTITY +|nmod|progenitors +|nsubj|Expansion Expansion|nmod|CD16 CD16|compound|END_ENTITY	Expansion and differentiation of CD14 + CD16 -LRB- - -RRB- and CD14 + + CD16 + human monocyte subsets from cord blood CD34 + hematopoietic progenitors .
18752636	0	CD34	0,4	CD14	56,60	CD34	CD14	947	929	Gene	Gene	cells|compound|START_ENTITY augment|nsubj|cells augment|dobj|differentiation differentiation|nmod|cells cells|nummod|+ +|compound|END_ENTITY	CD34 + cells augment endothelial cell differentiation of CD14 + endothelial progenitor cells in vitro .
21808991	0	CD34	6,10	CD14	0,4	CD34	CD14	947	929	Gene	Gene	+|compound|START_ENTITY population|nsubj|+ END_ENTITY|parataxis|population	CD14 - / CD34 + is the founding population of umbilical cord blood-derived endothelial progenitor cells and angiogenin1 is an important factor promoting the colony formation .
7691941	1	CD34	141,145	CD14	153,157	CD34	CD14	947	929	Gene	Gene	+|compound|START_ENTITY +|appos|+ progenitor|nmod|+ Ly|dep|progenitor Ly|parataxis|END_ENTITY	Characterization of the circulating mast cell progenitor as a c-kit + , CD34 + , Ly - , CD14 - , CD17 - , colony-forming cell .
9051248	0	CD34	96,100	CD14	46,50	CD34	CD14	947	929	Gene	Gene	cells|compound|START_ENTITY system|nmod|cells system|nmod|cells cells|compound|END_ENTITY	A rapid nylon-fiber syringe system to deplete CD14 + cells for positive selection of human blood CD34 + cells .
9715264	0	CD34	97,101	CD14	121,125	CD34	CD14	947	929	Gene	Gene	precursors|amod|START_ENTITY precursors|amod|END_ENTITY	IL-4 and CD40 ligation affect differently the differentiation , maturation , and function of human CD34 + cell-derived CD1a + CD14 - and CD1a-CD14 + dendritic cell precursors in vitro .
22214418	0	CD34	23,27	CD144	29,34	CD34	CD144	947	1003	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	Decreased pre-surgical CD34 + / CD144 + cell number in patients undergoing coronary artery bypass grafting compared to coronary_artery_disease-free valvular patients .
25542764	0	CD34	0,4	CD144	6,11	CD34	CD144	947	1003	Gene	Gene	+|compound|START_ENTITY +|parataxis|Circulating Circulating|nsubj|+ +|compound|END_ENTITY	CD34 + / CD144 + Circulating Endothelial Cells as an Indicator of Carotid_Atherosclerosis .
24441947	0	CD34	60,64	CD15	54,58	CD34	CD15	947	2526	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Normal karyotype acute_myeloid_leukemia with the CD7 + CD15 + CD34 + HLA-DR + immunophenotype is a clinically distinct entity with a favorable outcome .
9335318	0	CD34	80,84	CD15	38,42	CD34	CD15	947	2526	Gene	Gene	cells|nummod|START_ENTITY population|nmod|cells Characterization|dep|population Characterization|nmod|CD11b CD11b|nummod|+ +|compound|END_ENTITY	Characterization of a culture-derived CD15 + CD11b - promyelocytic population from CD34 + peripheral blood cells .
9473215	0	CD34	87,91	CD18	60,64	CD34	CD18	947	3689	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Retroviral-mediated gene transfer of the leukocyte integrin CD18 into peripheral blood CD34 + cells derived from a patient with leukocyte_adhesion_deficiency_type_1 .
10066438	0	CD34	63,67	CD19	55,59	CD34	CD19	12490(Tax:10090)	12478(Tax:10090)	Gene	Gene	protein|parataxis|START_ENTITY protein|dep|END_ENTITY	S. _ aureus superantigen protein A expands CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- / CD19 -LRB- + -RRB- / CD34 -LRB- + -RRB- cells in mice : a potential immunorestorer .
16225771	0	CD34	112,116	CD19	107,111	CD34	CD19	947	930	Gene	Gene	B|compound|START_ENTITY B|compound|END_ENTITY	PEG10 activation by co-stimulation of CXCR5 and CCR7 essentially contributes to resistance to apoptosis in CD19 + CD34 + B cells from patients with B cell lineage acute and chronic_lymphocytic_leukemia .
18160830	0	CD34	52,56	CD19	59,63	CD34	CD19	947	930	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD34	65,69	CD19	59,63	CD34	CD19	947	930	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|dep|+ +|appos|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18418410	0	CD34	0,4	CD19	10,14	CD34	CD19	947	930	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD34 + CD38 + CD19 + as well as CD34 + CD38-CD19 + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL .
24598641	0	CD34	1,5	CD19	8,12	CD34	CD19	947	930	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	-LSB- CD34 -LRB- + -RRB- CD19 -LRB- + -RRB- cells with CD123 overexpression are a novel prognostic marker in Ph chromosome-positive acute_lymphoblastic_leukemia -RSB- .
9057669	0	CD34	0,4	CD19	67,71	CD34	CD19	947	930	Gene	Gene	cells|nummod|START_ENTITY express|nsubj|cells express|dobj|mRNA mRNA|compound|END_ENTITY	CD34 + cells in the blood of patients with multiple_myeloma express CD19 and IgH mRNA and have patient-specific IgH VDJ gene rearrangements .
9477126	0	CD34	41,45	CD19	36,40	CD34	CD19	947	930	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Prognostic significance of the CD10 + CD19 + CD34 + B-progenitor immunophenotype in children with acute_lymphoblastic_leukemia : a report from the Children 's Cancer Group .
9593276	0	CD34	79,83	CD19	43,47	CD34	CD19	947	930	Gene	Gene	progenitors|compound|START_ENTITY +|nmod|progenitors +|nsubj|system system|nmod|production production|nmod|IgM IgM|compound|END_ENTITY	Culture system for extensive production of CD19 + IgM + cells by human cord blood CD34 + progenitors .
16863912	0	CD34	110,114	CD26	42,46	CD34	CD26	947	1803	Gene	Gene	CD38|compound|START_ENTITY response|nmod|CD38 downregulates|dobj|response downregulates|nsubj|upregulation upregulation|nmod|peptidase peptidase|compound|END_ENTITY	G-CSF - and GM-CSF-induced upregulation of CD26 peptidase downregulates the functional chemotactic response of CD34 + CD38 - human cord blood hematopoietic cells .
17610364	0	CD34	39,43	CD26	14,18	CD34	CD26	947	1803	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Inhibition of CD26 in human cord blood CD34 + cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice .
17610365	0	CD34	19,23	CD26	0,4	CD34	CD26	947	1803	Gene	Gene	hematopoietic|compound|START_ENTITY inhibition|nmod|hematopoietic inhibition|nummod|END_ENTITY	CD26 inhibition on CD34 + or lineage - human umbilical cord blood donor hematopoietic stem cells/hematopoietic progenitor cells improves long-term engraftment into NOD/SCID/Beta2null immunodeficient mice .
14977470	0	CD34	95,99	CD31	89,93	CD34	CD31	947	5175	Gene	Gene	+|dep|START_ENTITY +|dep|END_ENTITY	Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1 + / CD31 - / CD34 - Progenitors .
11940478	0	CD34	20,24	CD33	34,38	CD34	CD33	947	945	Gene	Gene	+|compound|START_ENTITY +|appos|CD13 CD13|nummod|END_ENTITY	Characterization of CD34 + , CD13 + , CD33 - cells , a rare subset of immature human hematopoietic cells .
12063025	0	CD34	129,133	CD33	87,91	CD34	CD33	947	945	Gene	Gene	cells|compound|START_ENTITY fraction|nmod|cells fraction|amod|enriched enriched|nmod|CD38 CD38|compound|END_ENTITY	Myeloid-lymphoid initiating cells -LRB- ML-IC -RRB- are highly enriched in the rhodamine-c-kit -LRB- + -RRB- CD33 -LRB- - -RRB- CD38 -LRB- - -RRB- fraction of umbilical cord CD34 -LRB- + -RRB- cells .
16809615	0	CD34	36,40	CD33	42,46	CD34	CD33	947	945	Gene	Gene	precursors|compound|START_ENTITY precursors|dep|END_ENTITY	FLT3 internal tandem duplication in CD34 + / CD33 - precursors predicts poor outcome in acute_myeloid_leukemia .
1716590	0	CD34	139,143	CD33	133,137	CD34	CD33	947	945	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Blast colony-forming_cells and precursors of colony-forming_cells detectable in long-term marrow culture express the same phenotype -LRB- CD33 - CD34 + -RRB- .
17181570	0	CD34	42,46	CD33	34,38	CD34	CD33	947	945	Gene	Gene	+|compound|START_ENTITY Expression|nmod|+ Expression|nmod|END_ENTITY	Expression of the target receptor CD33 in CD34 + / CD38 - / CD123 + AML stem cells .
17453971	0	CD34	36,40	CD33	129,133	CD34	CD33	947	945	Gene	Gene	patients|amod|START_ENTITY progenitors|nmod|patients lack|nsubj|progenitors lack|ccomp|express express|dobj|END_ENTITY	Primitive AML progenitors from most CD34 -LRB- + -RRB- patients lack CD33 expression but progenitors from many CD34 -LRB- - -RRB- AML patients express CD33 .
17453971	0	CD34	36,40	CD33	58,62	CD34	CD33	947	945	Gene	Gene	patients|amod|START_ENTITY progenitors|nmod|patients lack|nsubj|progenitors lack|ccomp|express express|nsubj|patients patients|compound|expression expression|nummod|END_ENTITY	Primitive AML progenitors from most CD34 -LRB- + -RRB- patients lack CD33 expression but progenitors from many CD34 -LRB- - -RRB- AML patients express CD33 .
21729522	0	CD34	89,93	CD33	81,85	CD34	CD33	947	945	Gene	Gene	cells|compound|START_ENTITY cells|amod|binding binding|nmod|surface surface|nmod|/ /|compound|END_ENTITY	-LSB- Screening and structure analysis of nucleic acid aptamers binding to surface of CD33 -LRB- + -RRB- / CD34 -LRB- + -RRB- cells from patients with acute_myeloid_leukemia subtype M -RSB- .
21993666	0	CD34	0,4	CD33	73,77	CD34	CD33	947	945	Gene	Gene	stem|nsubj|START_ENTITY stem|dobj|cells cells|nmod|Siglec-3 Siglec-3|appos|END_ENTITY	CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- stem cells in chronic_myeloid_leukemia express Siglec-3 -LRB- CD33 -RRB- and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin .
7496354	0	CD34	0,4	CD33	6,10	CD34	CD33	947	945	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	CD34 + / CD33 + blast cells : correlation with FAB subtypes .
7514903	0	CD34	40,44	CD33	14,18	CD34	CD33	947	945	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD33 , CD38 , and HLA-DR on CD34 + human fetal liver progenitors with a high proliferative potential .
7533867	0	CD34	75,79	CD33	139,143	CD34	CD33	947	945	Gene	Gene	+|compound|START_ENTITY fraction|amod|+ isolated|nmod|fraction isolated|nmod|phenotype phenotype|appos|+ +|compound|END_ENTITY	Residual normal , highly proliferative progenitors can be isolated from the CD34 + / 33 - fraction of AML with a more differentiated phenotype -LRB- CD33 + -RRB- .
7687219	6	CD34	1019,1023	CD33	1024,1028	CD34	CD33	947	945	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Using this procedure , we carried out an analysis of c-kit mRNA expression in CD34 + CD33 - , CD34 + CD33 + , CD34-CD33 + , and CD34-CD33 - cells .
9091301	0	CD34	18,22	CD33	113,117	CD34	CD33	947	945	Gene	Gene	progenitors|compound|START_ENTITY myeloperoxidase-negative|nsubj|progenitors myeloperoxidase-negative|advmod|irrespective irrespective|nmod:npmod|coexpression coexpression|nummod|END_ENTITY	RhG-CSF-mobilized CD34 + peripheral blood progenitors are myeloperoxidase-negative and noncycling irrespective of CD33 or CD13 coexpression .
9733270	0	CD34	18,22	CD33	24,28	CD34	CD33	947	945	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	The importance of CD34 + / CD33 - cells in platelet engraftment after intensive therapy for cancer patients given peripheral blood stem cell rescue .
11493732	0	CD34	102,106	CD34	54,58	CD34	CD34	947	947	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Inverse relationship between patient peripheral blood CD34 + cell counts and collection efficiency for CD34 + cells in two automated leukapheresis systems .
11493732	0	CD34	54,58	CD34	102,106	CD34	CD34	947	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Inverse relationship between patient peripheral blood CD34 + cell counts and collection efficiency for CD34 + cells in two automated leukapheresis systems .
12835726	0	CD34	41,45	CD34	51,55	CD34	CD34	947	947	Gene	Gene	response|nmod|START_ENTITY response|dep|cells cells|nummod|END_ENTITY	Differential response of primitive human CD34 - and CD34 + hematopoietic cells to the Notch ligand Jagged-1 .
12835726	0	CD34	51,55	CD34	41,45	CD34	CD34	947	947	Gene	Gene	cells|nummod|START_ENTITY response|dep|cells response|nmod|END_ENTITY	Differential response of primitive human CD34 - and CD34 + hematopoietic cells to the Notch ligand Jagged-1 .
1378320	0	CD34	124,128	CD34	81,85	CD34	CD34	947	947	Gene	Gene	cells|compound|START_ENTITY primitive|nmod|cells primitive|nsubj|Expression Expression|nmod|molecules molecules|nmod|cells cells|dep|LFA-1 LFA-1|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
1378320	0	CD34	81,85	CD34	124,128	CD34	CD34	947	947	Gene	Gene	LFA-1|compound|START_ENTITY cells|dep|LFA-1 molecules|nmod|cells Expression|nmod|molecules primitive|nsubj|Expression primitive|nmod|cells cells|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
17379075	0	CD34	15,19	CD34	30,34	CD34	CD34	12490(Tax:10090)	12490(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	GFP-transduced CD34 + and Lin - CD34 - hematopoietic stem cells did not adopt a cardiac phenotype in a nonhuman primate model of myocardial_infarct .
17379075	0	CD34	30,34	CD34	15,19	CD34	CD34	12490(Tax:10090)	12490(Tax:10090)	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	GFP-transduced CD34 + and Lin - CD34 - hematopoietic stem cells did not adopt a cardiac phenotype in a nonhuman primate model of myocardial_infarct .
18160830	0	CD34	39,43	CD34	84,88	CD34	CD34	947	947	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD34	84,88	CD34	39,43	CD34	CD34	947	947	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18549635	0	CD34	113,117	CD34	89,93	CD34	CD34	947	947	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD34	89,93	CD34	113,117	CD34	CD34	947	947	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
8647230	0	CD34	18,22	CD34	78,82	CD34	CD34	101105675	101105675	Gene	Gene	+|compound|START_ENTITY Identification|nmod|+ subsets|nsubj|Identification subsets|advcl|stem stem|nsubj|selection selection|dep|engraftment engraftment|nmod|Lin Lin|compound|END_ENTITY	Identification of CD34 + subsets after glycoprotease selection : engraftment of CD34 + Thy-1 + Lin - stem cells in fetal sheep .
8647230	0	CD34	78,82	CD34	18,22	CD34	CD34	101105675	101105675	Gene	Gene	Lin|compound|START_ENTITY engraftment|nmod|Lin selection|dep|engraftment stem|nsubj|selection subsets|advcl|stem subsets|nsubj|Identification Identification|nmod|+ +|compound|END_ENTITY	Identification of CD34 + subsets after glycoprotease selection : engraftment of CD34 + Thy-1 + Lin - stem cells in fetal sheep .
8781417	0	CD34	114,118	CD34	79,83	CD34	CD34	947	947	Gene	Gene	Lin|compound|START_ENTITY cells|nmod|Lin cells|nummod|END_ENTITY	Thrombopoietin stimulates megakaryocytopoiesis , myelopoiesis , and expansion of CD34 + progenitor cells from single CD34 + Thy-1 + Lin - primitive progenitor cells .
8781417	0	CD34	79,83	CD34	114,118	CD34	CD34	947	947	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|Lin Lin|compound|END_ENTITY	Thrombopoietin stimulates megakaryocytopoiesis , myelopoiesis , and expansion of CD34 + progenitor cells from single CD34 + Thy-1 + Lin - primitive progenitor cells .
9639415	0	CD34	0,4	CD36	6,10	CD34	CD36	947	948	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	CD34 + / CD36 - cells from myelodysplasia patients have a limited capacity to proliferate but can differentiate in response to Epo and MGF stimulation .
10419883	0	CD34	119,123	CD38	126,130	CD34	CD38	947	952	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The soluble interleukin-6 -LRB- IL-6 -RRB- receptor/IL -6 fusion protein enhances in vitro maintenance and proliferation of human CD34 -LRB- + -RRB- CD38 -LRB- - / low -RRB- cells capable of repopulating severe_combined_immunodeficiency mice .
10477721	0	CD34	60,64	CD38	67,71	CD34	CD38	947	952	Gene	Gene	subset|nmod|START_ENTITY differentiation|nmod|subset END_ENTITY|nsubj|differentiation	Rapid differentiation of a rare subset of adult human lin -LRB- - -RRB- CD34 -LRB- - -RRB- CD38 -LRB- - -RRB- cells stimulated by multiple growth factors in vitro .
10516751	0	CD34	126,130	CD38	132,136	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY immunogenicity|nmod|+ immunophenotype|dep|immunogenicity immunophenotype|dep|END_ENTITY	The immunophenotype of minimally differentiated acute_myeloid_leukemia -LRB- AML-M0 -RRB- : reduced immunogenicity and high frequency of CD34 + / CD38 - leukemic progenitors .
10607692	0	CD34	30,34	CD38	37,41	CD34	CD38	947	952	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Expansion of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell -LRB- SRC -RRB- frequency : dissociation of SRC phenotype and function .
11342460	0	CD34	36,40	CD38	43,47	CD34	CD38	947	952	Gene	Gene	CXCR4|amod|START_ENTITY CXCR4|compound|END_ENTITY	Rapid and efficient homing of human CD34 -LRB- + -RRB- CD38 -LRB- - / low -RRB- CXCR4 -LRB- + -RRB- stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m -LRB- null -RRB- mice .
11388746	0	CD34	14,18	CD38	104,108	CD34	CD38	947	952	Gene	Gene	subsets|nummod|START_ENTITY Importance|nmod|subsets Importance|dep|experience experience|acl|using using|dobj|END_ENTITY	Importance of CD34 + cell subsets in autologous PBSC transplantation : the mulhouse experience using CD34 + CD38 - cells as predictive tool for hematopoietic engraftment .
11588023	8	CD34	1463,1467	CD38	1471,1475	CD34	CD38	947	952	Gene	Gene	showed|nsubj|START_ENTITY showed|parataxis|displayed displayed|nsubj|cells cells|compound|END_ENTITY	Leukemic CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- cells displayed a rapid induction of cell death in response to MG-132 , whereas normal CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- cells showed little if any effect .
11857070	0	CD34	60,64	CD38	78,82	CD34	CD38	947	952	Gene	Gene	conversion|nmod|START_ENTITY END_ENTITY|nsubj|conversion	Targeted beta-globin gene conversion in human hematopoietic CD34 -LRB- + -RRB- and Lin -LRB- - -RRB- CD38 -LRB- - -RRB- cells .
11999573	0	CD34	94,98	CD38	100,104	CD34	CD38	947	952	Gene	Gene	CD38|compound|START_ENTITY CD38|dep|+ +|compound|END_ENTITY	Induction of apoptosis by cladribine -LRB- 2-CdA -RRB- , gemcitabine and other chemotherapeutic drugs on CD34 + / CD38 + and CD34 + / CD38 - hematopoietic progenitor cells : selective effects of doxorubicin and 2-CdA with protection of immature cells .
12031654	0	CD34	58,62	CD38	65,69	CD34	CD38	947	952	Gene	Gene	receptor|nmod|START_ENTITY activation|nmod|receptor cells|amod|activation cells|compound|END_ENTITY	MAP kinase activation by mu opioid receptor in cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells .
12063025	0	CD34	129,133	CD38	94,98	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY fraction|nmod|cells fraction|amod|enriched enriched|nmod|END_ENTITY	Myeloid-lymphoid initiating cells -LRB- ML-IC -RRB- are highly enriched in the rhodamine-c-kit -LRB- + -RRB- CD33 -LRB- - -RRB- CD38 -LRB- - -RRB- fraction of umbilical cord CD34 -LRB- + -RRB- cells .
12070035	0	CD34	45,49	CD38	52,56	CD34	CD38	947	952	Gene	Gene	Thy-1|amod|START_ENTITY Thy-1|compound|END_ENTITY	Involvement and functional impairment of the CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- Thy-1 -LRB- + -RRB- hematopoietic stem cell pool in myelodysplastic_syndromes with trisomy 8 .
12358912	0	CD34	88,92	CD38	94,98	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY loss|nmod|+ cells|nmod|loss cells|dep|END_ENTITY	Low blood dendritic cells in chronic_myeloid_leukaemia patients correlates with loss of CD34 + / CD38 - primitive haematopoietic progenitors .
12675725	0	CD34	85,89	CD38	5,9	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY potential|nmod|cells cloning|dobj|potential marker|acl|cloning marker|nsubj|END_ENTITY	CD34 + CD38 - is a good predictive marker of cloning ability and expansion potential of CD34 + cord blood cells .
15764022	0	CD34	90,94	CD38	96,100	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Peripheral blood and BM CD34 + CD38 - cells show better resistance to cryopreservation than CD34 + CD38 + cells in autologous stem cell transplantation .
15790777	0	CD34	11,15	CD38	17,21	CD34	CD38	12490(Tax:10090)	952	Gene	Gene	+|compound|START_ENTITY G1|dep|+ G1|dep|potentiate potentiate|compound|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
15790777	0	CD34	11,15	CD38	91,95	CD34	CD38	12490(Tax:10090)	952	Gene	Gene	+|compound|START_ENTITY G1|dep|+ G1|parataxis|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
15790777	0	CD34	85,89	CD38	17,21	CD34	CD38	12490(Tax:10090)	952	Gene	Gene	+|compound|START_ENTITY potentiate|nmod|+ potentiate|compound|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
15790777	0	CD34	85,89	CD38	91,95	CD34	CD38	12490(Tax:10090)	952	Gene	Gene	+|compound|START_ENTITY potentiate|nmod|+ G1|dep|potentiate G1|parataxis|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
16321850	0	CD34	49,53	CD38	55,59	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Detection of molecular targets on the surface of CD34 + / CD38 -- stem cells in various myeloid_malignancies .
17170726	0	CD34	63,67	CD38	70,74	CD34	CD38	947	952	Gene	Gene	CD7|amod|START_ENTITY CD7|compound|END_ENTITY	T - , _ B - _ and_NK-lymphoid , but not myeloid cells arise from human CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- CD7 -LRB- + -RRB- common lymphoid progenitors expressing lymphoid-specific genes .
17181570	0	CD34	42,46	CD38	48,52	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Expression of the target receptor CD33 in CD34 + / CD38 - / CD123 + AML stem cells .
18160830	0	CD34	39,43	CD38	33,37	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|dep|+ END_ENTITY|dep|+	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD34	52,56	CD38	46,50	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD34	65,69	CD38	46,50	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD34	84,88	CD38	33,37	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18415658	0	CD34	30,34	CD38	36,40	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|dep|END_ENTITY	HERG K + channel expression in CD34 + / CD38 - / CD123 -LRB- high -RRB- cells and primary leukemia cells and analysis of its regulation in leukemia cells .
18418410	0	CD34	0,4	CD38	5,9	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD34 + CD38 + CD19 + as well as CD34 + CD38-CD19 + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL .
18549635	0	CD34	113,117	CD38	120,124	CD34	CD38	947	952	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD34	113,117	CD38	96,100	CD34	CD38	947	952	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|compound|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD34	89,93	CD38	120,124	CD34	CD38	947	952	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD34	89,93	CD38	96,100	CD34	CD38	947	952	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
19644143	0	CD34	27,31	CD38	8,12	CD34	CD38	947	952	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduced CD38 expression on CD34 + cells as a diagnostic test in myelodysplastic_syndromes .
19937912	0	CD34	135,139	CD38	147,151	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|appos|cells cells|amod|END_ENTITY	Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34 + , CD34 + CD38 - and early lymphoid CD7 + cells .
19937912	0	CD34	142,146	CD38	147,151	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34 + , CD34 + CD38 - and early lymphoid CD7 + cells .
20444543	0	CD34	42,46	CD38	48,52	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Enrichment of N-Cadherin and Tie2-bearing CD34 + / CD38 - / CD123 + leukemic stem cells by chemotherapy-resistance .
21128225	0	CD34	133,137	CD38	140,144	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34 + / CD38 - cells and sensitizes them to antileukemia agents .
21993666	0	CD34	0,4	CD38	8,12	CD34	CD38	947	952	Gene	Gene	stem|nsubj|START_ENTITY stem|nsubj|END_ENTITY	CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- stem cells in chronic_myeloid_leukemia express Siglec-3 -LRB- CD33 -RRB- and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin .
22262762	0	CD34	45,49	CD38	52,56	CD34	CD38	12490(Tax:10090)	12494(Tax:10090)	Gene	Gene	population|nmod|START_ENTITY END_ENTITY|nsubj|population	A clinically relevant population of leukemic CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells in acute_myeloid_leukemia .
22306110	0	CD34	53,57	CD38	60,64	CD34	CD38	947	952	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The effects of ROS-mediating oxygen tension on human CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells induced into mature dendritic cells .
22926686	0	CD34	18,22	CD38	25,29	CD34	CD38	947	952	Gene	Gene	myeloblasts|amod|START_ENTITY myeloblasts|amod|END_ENTITY	The proportion of CD34 -LRB- + -RRB- CD38 -LRB- low or neg -RRB- myeloblasts , but not side population frequency , predicts initial response to induction therapy in patients with newly diagnosed acute_myeloid_leukemia .
23055153	0	CD34	0,4	CD38	8,12	CD34	CD38	12490(Tax:10090)	12494(Tax:10090)	Gene	Gene	___|compound|START_ENTITY ___|parataxis|express express|nsubj|cells cells|compound|END_ENTITY	CD34 ___ / CD38 ___ acute_myelogenous_leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells .
23564444	0	CD34	48,52	CD38	56,60	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-1b inhibits self-renewal capacity of dormant CD34 / CD38 acute_myelogenous_leukemia cells in vitro and in vivo .
23686525	0	CD34	0,4	CD38	8,12	CD34	CD38	947	952	Gene	Gene	___|compound|START_ENTITY ___|parataxis|express express|nsubj|cells cells|compound|END_ENTITY	CD34 ___ / CD38 acute_myelogenous_leukemia cells aberrantly express Aurora_kinase_A .
24023545	0	CD34	58,62	CD38	65,69	CD34	CD38	947	952	Gene	Gene	Expansion|nmod|START_ENTITY Expansion|dep|Cells Cells|compound|END_ENTITY	Wnt1 Accelerates an Ex Vivo Expansion of Human Cord Blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- Cells .
24038022	0	CD34	44,48	CD38	52,56	CD34	CD38	947	952	Gene	Gene	function|nmod|START_ENTITY Loss|nmod|function Loss|nmod|END_ENTITY	Loss of quiescence and impaired function of CD34 -LRB- + -RRB- / CD38 -LRB- low -RRB- cells one year following autologous stem cell transplantation .
24703771	0	CD34	29,33	CD38	36,40	CD34	CD38	12490(Tax:10090)	12494(Tax:10090)	Gene	Gene	leukemic|compound|START_ENTITY leukemic|compound|END_ENTITY	N-Cadherin and Tie2 positive CD34 CD38 CD123 leukemic stem cell populations can develop acute_myeloid_leukemia more effectively in NOD/SCID mice .
25102944	0	CD34	22,26	CD38	29,33	CD34	CD38	947	952	Gene	Gene	expansion|nmod|START_ENTITY END_ENTITY|nsubj|expansion	In vitro expansion of CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile_myelomonocytic_leukemia .
25588820	6	CD34	1771,1775	CD38	1780,1784	CD34	CD38	947	952	Gene	Gene	/|compound|START_ENTITY competition|nmod|/ transplanted|nmod|competition END_ENTITY|nsubj|transplanted	In vivo studies showed equivalent engraftment of transduced CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- cells when transplanted in competition with 100-fold more CD34 -LRB- + -RRB- / CD38 -LRB- + -RRB- cells .
25876768	0	CD34	150,154	CD38	160,164	CD34	CD38	947	952	Gene	Gene	blasts|amod|START_ENTITY blasts|amod|END_ENTITY	An immunophenotypic pre-treatment predictor for poor response to induction chemotherapy in older acute_myeloid_leukaemia patients : blood frequency of CD34 -LRB- + -RRB- CD38 -LRB- low -RRB- blasts .
26010294	0	CD34	128,132	CD38	122,126	CD34	CD38	947	952	Gene	Gene	cells|dep|START_ENTITY END_ENTITY|parataxis|cells	Differential antigen expression and aberrant signaling via PI3/AKT , MAP/ERK , JAK/STAT , and Wnt/b catenin pathways in Lin - / CD38 - / CD34 + cells in acute myeloid_leukemia .
26059451	0	CD34	27,31	CD38	35,39	CD34	CD38	947	952	Gene	Gene	DNMT3A|nmod|START_ENTITY DNMT3A|dep|AML AML|compound|END_ENTITY	STAT5A regulates DNMT3A in CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- AML cells .
26997358	0	CD34	130,134	CD38	79,83	CD34	CD38	947	952	Gene	Gene	Cells|compound|START_ENTITY expanded|nmod|Cells cells|acl|expanded END_ENTITY|dep|cells	Low oxygen tension favored expansion and hematopoietic reconstitution of CD34 + CD38 - cells expanded from human cord blood-derived CD34 + Cells .
7510144	0	CD34	53,57	CD38	69,73	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|appos|HLA-DR HLA-DR|nummod|END_ENTITY	Lymphoid and myeloid differentiation of single human CD34 + , HLA-DR + , CD38 - hematopoietic stem cells .
7520470	0	CD34	85,89	CD38	90,94	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Interferon_gamma selectively inhibits very primitive CD342 + CD38 - and not more mature CD34 + CD38 + human hematopoietic progenitor cells .
7520773	0	CD34	61,65	CD38	31,35	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY subfractions|nmod|cells differences|dep|subfractions differences|nmod|END_ENTITY	Functional differences between CD38 - and DR - subfractions of CD34 + bone marrow cells .
7548327	0	CD34	73,77	CD38	41,45	CD34	CD38	947	952	Gene	Gene	cells|nummod|START_ENTITY Effect|nmod|cells Effect|nmod|mobilization mobilization|nmod|subfractions subfractions|compound|END_ENTITY	Effect of rhG-CSF on the mobilization of CD38 and HLA-DR subfractions of CD34 + peripheral blood progenitor cells .
7613494	0	CD34	68,72	CD38	34,38	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY antigens|nmod|+ antigens|nsubj|Comparison Comparison|nmod|coexpression coexpression|nmod|END_ENTITY	Comparison of the coexpression of CD38 , CD33 and HLA-DR antigens on CD34 + purified cells from human cord blood and bone marrow .
7684620	0	CD34	76,80	CD38	83,87	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	A murine stromal cell line allows the proliferation of very primitive human CD34 + + / CD38 - progenitor cells in long-term cultures and semisolid assays .
8632913	0	CD34	90,94	CD38	101,105	CD34	CD38	947	952	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Tnk1 : a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34 + / Lin - / CD38 - stem/progenitor cells .
8676076	0	CD34	44,48	CD38	49,53	CD34	CD38	947	952	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Differential cytokine effects on primitive -LRB- CD34 + CD38 - -RRB- human hematopoietic cells : novel responses to Flt3-ligand and thrombopoietin .
8950234	0	CD34	139,143	CD38	144,148	CD34	CD38	947	952	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	TGF-beta and MIP-1_alpha exert their main inhibitory activity on very primitive CD34 +2 CD38 - cells but show opposite effects on more mature CD34 + CD38 + human hematopoietic progenitors .
9164933	0	CD34	114,118	CD38	120,124	CD34	CD38	947	952	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive -LRB- CD34 + CD38 - -RRB- human bone marrow progenitor cells : distinct and key interactions with the ligands for c-kit and flt3 , and inhibitory effects of TGF-beta and TNF-alpha .
9177436	0	CD34	0,4	CD38	43,47	CD34	CD38	947	952	Gene	Gene	cells|compound|START_ENTITY -|nsubj|cells -|compound|END_ENTITY	CD34 + megakaryoblastic leukaemic cells are CD38 - , but CD61 + and glycophorin A + : improved criteria for diagnosis of AML-M7 ?
9180291	0	CD34	24,28	CD38	95,99	CD34	CD38	947	952	Gene	Gene	subpopulations|nummod|START_ENTITY analysis|nmod|subpopulations characterized|nsubj|analysis characterized|nmod|expression expression|nmod|END_ENTITY	Cytogenetic analysis of CD34 + subpopulations in AML and MDS characterized by the expression of CD38 and CD117 .
9864151	0	CD34	19,23	CD38	32,36	CD34	CD38	947	952	Gene	Gene	adult|dep|START_ENTITY adult|parataxis|progenitors progenitors|nsubj|END_ENTITY	Single adult human CD34 -LRB- + -RRB- / Lin - / CD38 -LRB- - -RRB- progenitors give rise to natural killer cells , B-lineage cells , dendritic cells , and myeloid cells .
19180486	0	CD34	44,48	CD40	24,28	CD34	CD40	947	958	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Increased expression of CD40 on bone marrow CD34 + hematopoietic progenitor cells in patients with systemic_lupus_erythematosus : contribution to Fas-mediated apoptosis .
10195569	0	CD34	62,66	CD41	67,71	CD34	CD41	947	3674	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cytokine-induced expansion of human CD34 + stem/progenitor and CD34 + CD41 + early megakaryocytic marrow cells cultured on normal osteoblasts .
10663616	0	CD34	21,25	CD41	27,31	CD34	CD41	947	3674	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ expansion|parataxis|progenitors progenitors|nsubj|+ +|compound|END_ENTITY	Ex vivo expansion of CD34 + / CD41 + late progenitors from enriched peripheral blood CD34 + cells .
10663616	0	CD34	81,85	CD41	27,31	CD34	CD41	947	3674	Gene	Gene	cells|compound|START_ENTITY progenitors|nmod|cells progenitors|nsubj|+ +|compound|END_ENTITY	Ex vivo expansion of CD34 + / CD41 + late progenitors from enriched peripheral blood CD34 + cells .
11983103	0	CD34	72,76	CD41	77,81	CD34	CD41	947	3674	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation of time to platelet engraftment with amount of transplanted CD34 + CD41 + cells after allogeneic bone marrow transplantation .
8641347	0	CD34	18,22	CD41	23,27	CD34	CD41	947	3674	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Fetal bone marrow CD34 + CD41 + cells are enriched for multipotent hematopoietic progenitors , but not for pluripotent stem cells .
9808053	0	CD34	22,26	CD41	28,32	CD34	CD41	947	3674	Gene	Gene	CD41|compound|START_ENTITY CD41|dep|cells cells|nummod|+ +|compound|END_ENTITY	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
9808053	0	CD34	68,72	CD41	28,32	CD34	CD41	947	3674	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ cells|nummod|+ +|compound|END_ENTITY	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
9808053	0	CD34	68,72	CD41	74,78	CD34	CD41	947	3674	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ END_ENTITY|dep|cells	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
10520039	0	CD34	183,187	CD44	65,69	CD34	CD44	947	960	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells induced|nmod|expansion patterns|acl|induced patterns|nmod|END_ENTITY	Distinct patterns of apoptosis in association with modulation of CD44 induced by thrombopoietin and granulocyte-colony_stimulating_factor during ex vivo expansion of human cord blood CD34 + cells .
10924094	0	CD34	25,29	CD44	73,77	CD34	CD44	947	960	Gene	Gene	cells|amod|START_ENTITY kinetics|nmod|cells kinetics|nmod|expression expression|compound|END_ENTITY	Mobilization kinetics of CD34 -LRB- + -RRB- cells in association with modulation of CD44 and CD31 expression during continuous intravenous administration of G-CSF in normal donors .
15070674	0	CD34	74,78	CD44	0,4	CD34	CD44	947	960	Gene	Gene	cells|compound|START_ENTITY trafficking|nmod|cells SDF-1|nmod|trafficking cooperate|nmod|SDF-1 cooperate|nsubj|END_ENTITY	CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34 + stem/progenitor cells to bone marrow .
19024325	0	CD34	83,87	CD44	89,93	CD34	CD44	947	960	Gene	Gene	immunophenotype|nummod|START_ENTITY immunophenotype|nummod|END_ENTITY	-LSB- Multiparametric flow cytometry analyzes the expressions of immunophenotype CD133 , CD34 , CD44 in lung_cancer naive cells -RSB- .
19703720	0	CD34	34,38	CD44	96,100	CD34	CD44	947	960	Gene	Gene	+|compound|START_ENTITY cells|appos|+ Adhesion|nmod|cells dependent|nsubjpass|Adhesion dependent|advmod|END_ENTITY	Adhesion of human haematopoietic -LRB- CD34 + -RRB- stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4 .
21117906	0	CD34	36,40	CD44	43,47	CD34	CD44	947	960	Gene	Gene	CD90|amod|START_ENTITY CD90|compound|END_ENTITY	Isolation and expansion of synovial CD34 -LRB- - -RRB- CD44 -LRB- + -RRB- CD90 -LRB- + -RRB- mesenchymal stem cells : comparison of an enzymatic method and a direct explant technique .
22155731	0	CD34	15,19	CD44	23,27	CD34	CD44	947	960	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Synovial fluid CD34 CD44 CD90 mesenchymal stem cell levels are associated with the severity of primary_knee_osteoarthritis .
24680978	0	CD34	48,52	CD44	16,20	CD34	CD44	947	960	Gene	Gene	efficacy|nmod|START_ENTITY influences|dobj|efficacy influences|nsubj|Polymorphism Polymorphism|nmod|END_ENTITY	Polymorphism of CD44 influences the efficacy of CD34 -LRB- + -RRB- cells mobilization in patients with hematological_malignancies .
25262448	0	CD34	62,66	CD44	45,49	CD34	CD44	947	960	Gene	Gene	cells|compound|START_ENTITY silencing|nmod|cells silencing|nmod|receptor receptor|compound|END_ENTITY	Polymeric nanoparticle-mediated silencing of CD44 receptor in CD34 + acute_myeloid_leukemia cells .
9326174	0	CD34	46,50	CD44	14,18	CD34	CD44	947	960	Gene	Gene	cells|compound|START_ENTITY adhesion|nmod|cells enhance|dobj|adhesion enhance|nsubj|Antibodies Antibodies|nmod|END_ENTITY	Antibodies to CD44 enhance adhesion of normal CD34 + cells and acute myeloblastic but not lymphoblastic leukaemia cells to bone marrow_stroma .
12393728	0	CD34	85,89	CD45	0,4	CD34	CD45	12490(Tax:10090)	19264(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells inhibits|dobj|differentiation inhibits|nsubj|phosphatase phosphatase|nummod|END_ENTITY	CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34 + cells associated with selective inactivation of Lyn .
1694223	0	CD34	70,74	CD45	24,28	CD34	CD45	947	5788	Gene	Gene	subpopulations|nmod|START_ENTITY isoforms|nmod|subpopulations isoforms|nummod|END_ENTITY	Selective expression of CD45 isoforms on functional subpopulations of CD34 + hemopoietic cells from human bone marrow .
20493838	0	CD34	33,37	CD45	41,45	CD34	CD45	947	5788	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Impaired function of circulating CD34 -LRB- + -RRB- CD45 -LRB- - -RRB- cells in patients with proliferative_diabetic_retinopathy .
20568956	0	CD34	28,32	CD45	21,25	CD34	CD45	947	5788	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Umbilical cord blood CD45 -LRB- + -RRB- CD34 -LRB- + -RRB- cells coexpression in preterm and full-term neonates : a pilot study .
21715308	0	CD34	24,28	CD45	37,41	CD34	CD45	947	5788	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adult human circulating CD34 Lin CD45 CD133 cells can differentiate into hematopoietic and endothelial cells .
21789899	0	CD34	40,44	CD45	34,38	CD34	CD45	305081(Tax:10116)	24699(Tax:10116)	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Protection of bone marrow-derived CD45 + / CD34 - / lin - stromal cells with immunosuppressant activity against ischemia/reperfusion injury in rats .
23383116	0	CD34	19,23	CD45	12,16	CD34	CD45	305081(Tax:10116)	24699(Tax:10116)	Gene	Gene	+|compound|START_ENTITY KDR|dep|+ KDR|compound|END_ENTITY	Analysis of CD45 - -LSB- CD34 + / KDR + -RSB- endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic_stroke .
24763009	0	CD34	12,16	CD45	31,35	CD34	CD45	947	5788	Gene	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	-LSB- Changes of CD34 -LRB- + -RRB- and CD71 -LRB- + -RRB- CD45 -LRB- - -RRB- cell levels in bone marrow of MDS and AA patients -RSB- .
25332796	0	CD34	80,84	CD45	87,91	CD34	CD45	947	5788	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Percutaneous coronary intervention causes a rapid but transient mobilisation of CD34 -LRB- + -RRB- CD45 -LRB- - -RRB- cells .
26655331	0	CD34	100,104	CD45	108,112	CD34	CD45	947	5788	Gene	Gene	population|nmod|START_ENTITY properties|nmod|population gain|nmod|properties Aging|nmod|gain muscle|dep|Aging muscle|compound|END_ENTITY	Aging induced loss_of_stemness with concomitant gain of myogenic properties of a pure population of CD34 -LRB- + -RRB- / CD45 -LRB- - -RRB- muscle derived stem cells .
7541368	0	CD34	51,55	CD54	32,36	CD34	CD54	947	3383	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of adhesion molecule CD54 expression on CD34 + hematopoietic progenitors .
12482338	0	CD34	22,26	CD59	30,34	CD34	CD59	947	966	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Ex vivo expansion of CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from bone marrow of paroxysmal_nocturnal_hemoglobinuria patients -RSB- .
12744742	0	CD34	86,90	CD59	93,97	CD34	CD59	947	966	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	-LSB- Application of double immunomagnetic positive sorting to ex vivo expansion of marrow CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
18261338	0	CD34	40,44	CD59	47,51	CD34	CD59	947	966	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Long-term ability for hematopoiesis of CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from patients with paroxysmal_nocturnal_hemoglobinuria : experiment with mice -RSB- .
23965874	0	CD34	43,47	CD59	50,54	CD34	CD59	947	966	Gene	Gene	expansion|nmod|START_ENTITY END_ENTITY|nsubj|expansion	-LSB- Ex vivo expansion and clonal variation of CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from bone marrow in children with paroxysmal_nocturnal_hemoglobinuria -RSB- .
8690053	0	CD34	72,76	CD59	44,48	CD34	CD59	947	966	Gene	Gene	cells|nummod|START_ENTITY subset|nmod|cells identifies|dobj|subset identifies|nsubj|expression expression|nmod|epitope epitope|nmod|END_ENTITY	High-level expression of a novel epitope of CD59 identifies a subset of CD34 + bone marrow cells highly enriched for pluripotent stem cells .
19099641	0	CD34	21,25	CD61	26,30	CD34	CD61	947	3690	Gene	Gene	precursors|compound|START_ENTITY precursors|compound|END_ENTITY	-LSB- Correlation between CD34 + CD61 + megakaryocyte precursors and platelet engraftment in allogeneic hematopoietic stem cell transplantation -RSB- .
22378601	0	CD34	44,48	CD61	84,88	CD34	CD61	12490(Tax:10090)	16416(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY characterization|nmod|cells identifies|nsubj|characterization identifies|dobj|cells cells|dep|END_ENTITY	Functional characterization of TPO-expanded CD34 + cord blood cells identifies CD34 - CD61 - cells as platelet-producing cells early after transplantation in NOD/SCID mice and rCD34 + cells as CAFC colony-forming cells .
22378601	0	CD34	78,82	CD61	84,88	CD34	CD61	12490(Tax:10090)	16416(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Functional characterization of TPO-expanded CD34 + cord blood cells identifies CD34 - CD61 - cells as platelet-producing cells early after transplantation in NOD/SCID mice and rCD34 + cells as CAFC colony-forming cells .
14990114	0	CD34	22,26	CD62L	27,32	CD34	CD62L	947	6402	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effect of numbers of CD34 + CD62L + cells infused on unrelated umbilical cord blood transplantation in children with acute_leukemia -RSB- .
10398310	0	CD34	18,22	CD7	0,3	CD34	CD7	947	924	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	CD7 expression on CD34 + cells from chronic_myeloid_leukaemia in chronic phase .
11090056	0	CD34	76,80	CD7	83,86	CD34	CD7	947	924	Gene	Gene	START_ENTITY|dep|CD45RA CD45RA|compound|END_ENTITY	Characterization of dendritic cell differentiation pathways from cord blood CD34 -LRB- + -RRB- CD7 -LRB- + -RRB- CD45RA -LRB- + -RRB- hematopoietic progenitor cells .
12950236	0	CD34	18,22	CD7	0,3	CD34	CD7	947	924	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ END_ENTITY|dep|expression	CD7 expression by CD34 + cells in CML patients , of prognostic significance ?
15701834	0	CD34	0,4	CD7	5,8	CD34	CD7	947	924	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD34 + CD7 + leukemic progenitor cells may be involved in maintenance and clonal evolution of chronic_myeloid_leukemia .
16144796	0	CD34	23,27	CD7	64,67	CD34	CD7	947	924	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ profiling|nmod|cells identifies|nsubj|profiling identifies|dobj|expression expression|nmod|END_ENTITY	Molecular profiling of CD34 + cells identifies low expression of CD7 , along with high expression of proteinase_3 or elastase , as predictors of longer survival in patients with CML .
17852828	0	CD34	26,30	CD7	19,22	CD34	CD7	947	924	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|nmod|cells	High expression of CD7 on CD34 + cells is not linked to deletion of derivative chromosome 9 or lack of dendritic cells in chronic_myeloid_leukaemia .
24441947	0	CD34	60,64	CD7	49,52	CD34	CD7	947	924	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Normal karyotype acute_myeloid_leukemia with the CD7 + CD15 + CD34 + HLA-DR + immunophenotype is a clinically distinct entity with a favorable outcome .
9220659	0	CD34	27,31	CD7	86,89	CD34	CD7	947	924	Gene	Gene	expressing|compound|START_ENTITY myeloid|nsubj|expressing myeloid|dobj|line line|acl|established established|nmod|END_ENTITY	GM-CSF - and IL-3-dependent CD34 expressing myeloid cell line -LRB- SAS-1 -RRB- established from CD7 and CD34 expressing acute myeloblastic leukemic cells .
9364871	0	CD34	7,11	CD7	1,4	CD34	CD7	947	924	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	-LSB- CD7 + , CD34 + , electronmicroscopically peroxidase-negative acute_leukemia transformed from polycythemia vera after 12 years follow-up -RSB- .
9632270	0	CD34	25,29	CD71	31,35	CD34	CD71	947	7037	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Bone marrow steady-state CD34 + / CD71 - cell content is a predictive value of rG-CSF-mobilized CD34 + cells .
9632270	0	CD34	92,96	CD71	31,35	CD34	CD71	947	7037	Gene	Gene	cells|compound|START_ENTITY value|nmod|cells value|nsubj|+ +|dep|END_ENTITY	Bone marrow steady-state CD34 + / CD71 - cell content is a predictive value of rG-CSF-mobilized CD34 + cells .
10557051	0	CD34	99,103	CD90	45,49	CD34	CD90	947	7070	Gene	Gene	subfractions|appos|START_ENTITY Detection|dep|subfractions Detection|nmod|aberrations aberrations|nmod|END_ENTITY	Detection of cytogenetic aberrations both in CD90 -LRB- Thy-1 -RRB- - positive and -LRB- Thy-1 -RRB- - negative stem cell -LRB- CD34 -RRB- subfractions of patients with acute and chronic_myeloid_leukemias .
11238132	0	CD34	87,91	CD90	92,96	CD34	CD90	947	7070	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Replicative stress after allogeneic bone marrow transplantation : changes in cycling of CD34 + CD90 + and CD34 + CD90 - hematopoietic progenitors .
11918561	0	CD34	0,4	CD90	6,10	CD34	CD90	947	7070	Gene	Gene	+|compound|START_ENTITY +|parataxis|predict predict|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD34 + / CD90 + cells infused best predict late haematopoietic reconstitution following autologous peripheral blood stem cell transplantation .
22155731	0	CD34	15,19	CD90	31,35	CD34	CD90	947	7070	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Synovial fluid CD34 CD44 CD90 mesenchymal stem cell levels are associated with the severity of primary_knee_osteoarthritis .
22981934	0	CD34	68,72	CD90	91,95	CD34	CD90	947	7070	Gene	Gene	CD38|compound|START_ENTITY multipotentiality|nmod|CD38 preserve|dobj|multipotentiality preserve|dobj|END_ENTITY	Notch signals contribute to preserve the multipotentiality of human CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- CD45RA -LRB- - -RRB- CD90 -LRB- + -RRB- hematopoietic progenitors by maintaining T cell lineage differentiation potential .
23129214	0	CD34	14,18	CD90	20,24	CD34	CD90	947	7070	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Human adipose CD34 + CD90 + stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues .
9028155	0	CD34	29,33	CDw90	1,6	CD34	CDw90	947	7070	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	-LSB- CDw90 -LRB- Thy-1 -RRB- expression on CD34 positive cells in peripheral blood stem cell harvest -RSB- .
10381499	0	CD34	6,10	CXCR4	28,33	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	Human CD34 -LRB- + -RRB- cells express CXCR4 and its ligand stromal_cell-derived_factor-1 .
12004084	0	CD34	18,22	CXCR4	23,28	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immature leukemic CD34 + CXCR4 + cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1 .
12899713	0	CD34	99,103	CXCR4	0,5	CD34	CXCR4	947	7852	Gene	Gene	progenitors|compound|START_ENTITY migration|nmod|progenitors mediate|dobj|migration mediate|nsubj|receptors receptors|nummod|END_ENTITY	CXCR4 chemokine receptors -LRB- CD184 -RRB- and alpha4beta1 integrins mediate spontaneous migration of human CD34 + progenitors and acute_myeloid_leukaemia cells beneath marrow stromal cells -LRB- pseudoemperipolesis -RRB- .
15020611	0	CD34	22,26	CXCR4	66,71	CD34	CXCR4	947	7852	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|administration administration|nmod|AMD3100 AMD3100|compound|END_ENTITY	Rapid mobilization of CD34 + cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple_myeloma and non-Hodgkin 's _ lymphoma .
15070669	0	CD34	33,37	CXCR4	18,23	CD34	CXCR4	947	7852	Gene	Gene	progenitors|compound|START_ENTITY END_ENTITY|nmod|progenitors	Overexpression of CXCR4 on human CD34 + progenitors increases their proliferation , migration , and NOD/SCID repopulation .
15377464	0	CD34	63,67	CXCR4	25,30	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY molecules|nmod|cells molecules|compound|END_ENTITY	Pattern of expression of CXCR4 and adhesion molecules by human CD34 + cells from different sources : role in homing efficiency in NOD/SCID mice .
15536192	0	CD34	74,78	CXCR4	59,64	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY localization|nmod|cells localization|nmod|END_ENTITY	Intracellular localization and constitutive endocytosis of CXCR4 in human CD34 + hematopoietic progenitor cells .
15752146	0	CD34	41,45	CXCR4	194,199	CD34	CXCR4	947	7852	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ mobilization|nmod|cells stimulated|nsubj|mobilization stimulated|dobj|antagonist antagonist|compound|END_ENTITY	Augmented mobilization and collection of CD34 + hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating_factor by single-dose administration of AMD3100 , a CXCR4 antagonist .
16204315	0	CD34	79,83	CXCR4	53,58	CD34	CXCR4	947	7852	Gene	Gene	progenitors|compound|START_ENTITY expression|nmod|progenitors expression|nummod|END_ENTITY	cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34 + hematopoietic progenitors .
16247418	0	CD34	33,37	CXCR4	4,9	CD34	CXCR4	947	7852	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Low CXCR4 membrane expression on CD34 -LRB- + -RRB- cells characterizes cells mobilized to blood .
16267071	0	CD34	16,20	CXCR4	35,40	CD34	CXCR4	947	7852	Gene	Gene	Mobilization|nmod|START_ENTITY Mobilization|appos|END_ENTITY	Mobilization of CD34 -LRB- + -RRB- , CD117 -LRB- + -RRB- , CXCR4 -LRB- + -RRB- , c-met -LRB- + -RRB- stem cells is correlated with left_ventricular_ejection_fraction and plasma NT-proBNP levels in patients with acute_myocardial_infarction .
16467205	0	CD34	100,104	CXCR4	58,63	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY receptors|nmod|cells receptors|nummod|END_ENTITY	Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34 + marrow cells .
17023512	0	CD34	70,74	CXCR4	18,23	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY gene|nmod|cells Identification|nmod|gene Identification|nmod|END_ENTITY	Identification of CXCR4 as a new nitric_oxide-regulated gene in human CD34 + cells .
17350297	0	CD34	49,53	CXCR4	18,23	CD34	CXCR4	947	7852	Gene	Gene	cells|nummod|START_ENTITY down-regulated|nmod|cells down-regulated|nsubjpass|expression expression|nmod|END_ENTITY	The expression of CXCR4 is down-regulated on the CD34 + cells of patients with myelofibrosis_with_myeloid_metaplasia .
17533053	0	CD34	62,66	CXCR4	47,52	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY increases|nmod|cells increases|dobj|expression expression|nmod|END_ENTITY	Fucoidan ingestion increases the expression of CXCR4 on human CD34 + cells .
17765649	0	CD34	22,26	CXCR4	158,163	CD34	CXCR4	947	7852	Gene	Gene	+|compound|START_ENTITY Mobilization|nmod|+ stem|nsubj|Mobilization stem|nmod|consumption consumption|nmod|expression expression|dep|related related|nmod|modulation modulation|nmod|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
18511598	0	CD34	38,42	CXCR4	20,25	CD34	CXCR4	947	7852	Gene	Gene	promoter|nmod|START_ENTITY promoter|nummod|END_ENTITY	Hypermethylation of CXCR4 promoter in CD34 + cells from patients with primary myelofibrosis .
18628138	0	CD34	33,37	CXCR4	84,89	CD34	CXCR4	947	7852	Gene	Gene	Progenitor|compound|START_ENTITY Leukocytosis|nmod|Progenitor Cells|nsubj|Leukocytosis Cells|nmod|AMD3100 AMD3100|appos|Antagonist Antagonist|compound|END_ENTITY	Leukocytosis and Mobilization of CD34 + Hematopoietic Progenitor Cells by AMD3100 , a CXCR4 Antagonist .
19113880	0	CD34	51,55	CXCR4	120,125	CD34	CXCR4	12490(Tax:10090)	12767(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY culture|nmod|cells enhances|nsubj|culture enhances|nmod|expression expression|compound|END_ENTITY	Short-term culture of umbilical cord blood-derived CD34 cells enhances engraftment into NOD/SCID mice through increased CXCR4 expression .
19208649	0	CD34	55,59	CXCR4	60,65	CD34	CXCR4	947	7852	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Intracoronary infusion of bone marrow-derived selected CD34 + CXCR4 + cells and non-selected mononuclear cells in patients with acute STEMI and reduced left_ventricular_ejection_fraction : results of randomized , multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial_Infarction -LRB- REGENT -RRB- Trial .
19463855	0	CD34	51,55	CXCR4	19,24	CD34	CXCR4	947	7852	Gene	Gene	hematopoietic|compound|START_ENTITY SDF-KDEL|nmod|hematopoietic expression|nmod|SDF-KDEL expression|nummod|END_ENTITY	Down-regulation of CXCR4 expression by SDF-KDEL in CD34 -LRB- + -RRB- hematopoietic stem cells : An anti-human immunodeficiency virus strategy .
20957366	0	CD34	50,54	CXCR4	0,5	CD34	CXCR4	947	7852	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CXCR4 expression on transplanted peripheral blood CD34 + cells : relationship to engraftment after autologous transplantation in a cohort of multiple myeloma patients .
23060089	0	CD34	20,24	CXCR4	0,5	CD34	CXCR4	947	7852	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CXCR4 expression in CD34 + cells and unit predominance after double umbilical cord blood transplantation .
24673458	0	CD34	46,50	CXCR4	4,9	CD34	CXCR4	947	7852	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	The CXCR4 and adhesion molecule expression of CD34 + hematopoietic cells mobilized by `` on-demand '' addition of plerixafor to granulocyte-colony-stimulating_factor .
26209038	0	CD34	85,89	CXCR4	92,97	CD34	CXCR4	947	7852	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , increases the number of circulating CD34 -LRB- + -RRB- CXCR4 -LRB- + -RRB- cells in patients with type 2 diabetes .
26209038	0	CD34	85,89	CXCR4	92,97	CD34	CXCR4	947	7852	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , increases the number of circulating CD34 -LRB- + -RRB- CXCR4 -LRB- + -RRB- cells in patients with type 2 diabetes .
26436997	0	CD34	41,45	CXCR4	62,67	CD34	CXCR4	947	7852	Gene	Gene	DNAM-1|compound|START_ENTITY exit|nmod|DNAM-1 exit|dep|+ +|compound|END_ENTITY	'Em ergency exit ' of bone-marrow-resident CD34 -LRB- + -RRB- DNAM-1 -LRB- bright -RRB- CXCR4 -LRB- + -RRB- - committed lymphoid precursors during chronic infection and inflammation .
11389015	0	CD34	41,45	CrkL	20,24	CD34	CrkL	947	1399	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	The adapter protein CrkL associates with CD34 .
17412886	0	CD34	31,35	ELA2	12,16	CD34	ELA2	305081(Tax:10116)	24332(Tax:10116)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	High PR3 or ELA2 expression by CD34 + cells in advanced-phase chronic_myeloid_leukemia is associated with improved outcome following allogeneic stem_cell_transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects .
12889478	0	CD34	28,32	Endoglycan	0,10	CD34	Endoglycan	947	50512	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Endoglycan , a member of the CD34 family , functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x .
18606703	0	CD34	28,32	Endoglycan	0,10	CD34	Endoglycan	947	50512	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Endoglycan , a member of the CD34 family of sialomucins , is a ligand for the vascular selectins .
10923402	0	CD34	90,94	FLT3_ligand	29,40	CD34	FLT3 ligand	947	2323	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells END_ENTITY|nmod|expansion	-LSB- Effect of recombinant human FLT3_ligand -LRB- rhFL -RRB- on in vitro expansion of human cord blood CD34 + cells -RSB- .
11380462	0	CD34	34,38	Fas_antigen	134,145	CD34	Fas antigen	947	355	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|dep|relationship relationship|nmod|apoptosis apoptosis|nmod|END_ENTITY	Bcl-2 and Bcl-x expression in the CD34 + cells of aplastic_anaemia patients : relationship with increased apoptosis and upregulation of Fas_antigen .
7538820	0	CD34	26,30	Fas_antigen	0,11	CD34	Fas antigen	947	355	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Fas_antigen expression on CD34 + human marrow cells is induced by interferon_gamma and tumor_necrosis_factor_alpha and potentiates cytokine-mediated hematopoietic suppression in vitro .
7577642	0	CD34	51,55	Fas_antigen	24,35	CD34	Fas antigen	947	355	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Increased expression of Fas_antigen on bone marrow CD34 + cells of patients with aplastic_anaemia .
7522630	0	CD34	111,115	Fc_epsilon_RI	117,130	CD34	Fc epsilon RI	947	2205	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34 + / Fc_epsilon_RI - cell population .
19286928	0	CD34	57,61	Flk-1	68,73	CD34	Flk-1	947	3791	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of putative endothelial progenitor cells -LRB- CD34 + CD133 + Flk-1 + -RRB- in endarterectomized tissue of patients with chronic thromboembolic_pulmonary_hypertension .
20117086	0	CD34	68,72	Flk-1	61,66	CD34	Flk-1	947	3791	Gene	Gene	chemotaxis|nummod|START_ENTITY +|dobj|chemotaxis +|nsubj|modulates modulates|nmod|END_ENTITY	Extracellular calcium modulates in vitro bone marrow-derived Flk-1 + CD34 + progenitor cell chemotaxis and differentiation through a calcium-sensing_receptor .
12842710	0	CD34	75,79	Flk1	61,65	CD34	Flk1	947	3791	Gene	Gene	marrow-derived|xcomp|START_ENTITY marrow-derived|dobj|CD31 CD31|compound|END_ENTITY	Hemangioblastic characteristics of fetal bone marrow-derived Flk1 -LRB- + -RRB- CD31 -LRB- - -RRB- CD34 -LRB- - -RRB- cells .
14977470	0	CD34	95,99	Flk1	83,87	CD34	Flk1	947	3791	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1 + / CD31 - / CD34 - Progenitors .
12513756	0	CD34	55,59	Flt3	26,30	CD34	Flt3	12490(Tax:10090)	14255(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Functional expression of Flt3 and c-kit on cord blood CD34 -LRB- + -RRB- stem/progenitor cells and its significance -RSB- .
10037043	0	CD34	56,60	G-CSF	93,98	CD34	G-CSF	947	1440	Gene	Gene	expression|nmod|START_ENTITY Modulation|nmod|expression +|nsubj|Modulation +|nmod|END_ENTITY	Modulation of VLA-4 and L-selectin expression on normal CD34 + cells during mobilization with G-CSF .
10414910	0	CD34	45,49	G-CSF	18,23	CD34	G-CSF	947	1440	Gene	Gene	+|compound|START_ENTITY administration|nmod|+ administration|amod|END_ENTITY	Optimal timing of G-CSF administration after CD34 + immunoselected peripheral blood progenitor cell transplantation .
10595815	0	CD34	133,137	G-CSF	74,79	CD34	G-CSF	947	1440	Gene	Gene	collections|compound|START_ENTITY cost-effective|nsubj|collections using|parataxis|cost-effective using|dobj|END_ENTITY	Matched-pair analysis of hematopoietic progenitor cell mobilization using G-CSF vs. cyclophosphamide , etoposide , and G-CSF : enhanced CD34 + cell collections are not necessarily cost-effective .
10738037	0	CD34	119,123	G-CSF	54,59	CD34	G-CSF	947	1440	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ numbers|nmod|cells achieve|dobj|numbers failing|xcomp|achieve patients|acl|failing END_ENTITY|nmod|patients	Successful mobilization of peripheral blood HPCs with G-CSF alone in patients failing to achieve sufficient numbers of CD34 + cells and/or CFU-GM with chemotherapy and G-CSF .
10924094	0	CD34	25,29	G-CSF	146,151	CD34	G-CSF	947	1440	Gene	Gene	cells|amod|START_ENTITY kinetics|nmod|cells kinetics|nmod|END_ENTITY	Mobilization kinetics of CD34 -LRB- + -RRB- cells in association with modulation of CD44 and CD31 expression during continuous intravenous administration of G-CSF in normal donors .
11239221	0	CD34	0,4	G-CSF	102,107	CD34	G-CSF	947	1440	Gene	Gene	mobilization|compound|START_ENTITY mobilization|dep|efficacy efficacy|nmod|course course|nmod|END_ENTITY	CD34 + cell mobilization for allogeneic progenitor cell transplantation : efficacy of a short course of G-CSF .
12424191	0	CD34	75,79	G-CSF	102,107	CD34	G-CSF	947	1440	Gene	Gene	START_ENTITY|ccomp|superior superior|xcomp|END_ENTITY	Retroviral transduction efficiency of G-CSF + SCF-mobilized peripheral blood CD34 + cells is superior to G-CSF or G-CSF + Flt3-L-mobilized cells in nonhuman primates .
12424191	0	CD34	75,79	G-CSF	38,43	CD34	G-CSF	947	1440	Gene	Gene	START_ENTITY|nsubj|efficiency efficiency|nmod|blood blood|compound|END_ENTITY	Retroviral transduction efficiency of G-CSF + SCF-mobilized peripheral blood CD34 + cells is superior to G-CSF or G-CSF + Flt3-L-mobilized cells in nonhuman primates .
15308328	0	CD34	84,88	G-CSF	0,5	CD34	G-CSF	947	1440	Gene	Gene	+|compound|START_ENTITY adhesion|nmod|+ promoting|dobj|adhesion cells|acl|promoting VCAM-1|nmod|cells cells|amod|VCAM-1 expression|nmod|cells increases|dobj|expression increases|nsubj|END_ENTITY	G-CSF increases the expression of VCAM-1 on stromal cells promoting the adhesion of CD34 + hematopoietic cells : studies under flow conditions .
16532489	0	CD34	51,55	G-CSF	147,152	CD34	G-CSF	947	1440	Gene	Gene	mobilization|nmod|START_ENTITY affect|dobj|mobilization factors|acl:relcl|affect factors|dep|cells cells|nmod|donors donors|acl|treated treated|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|appos|END_ENTITY	Predictive factors that affect the mobilization of CD34 -LRB- + -RRB- cells in healthy donors treated with recombinant granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
16863912	0	CD34	110,114	G-CSF	0,5	CD34	G-CSF	947	1440	Gene	Gene	CD38|compound|START_ENTITY response|nmod|CD38 downregulates|dobj|response downregulates|nsubj|upregulation upregulation|amod|END_ENTITY	G-CSF - and GM-CSF-induced upregulation of CD26 peptidase downregulates the functional chemotactic response of CD34 + CD38 - human cord blood hematopoietic cells .
18457269	0	CD34	72,76	G-CSF	11,16	CD34	G-CSF	947	1440	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|dep|cells	-LSB- Effect of G-CSF on the proliferation and differentiation of bcr/abl -LRB- + -RRB- - CD34 + cells from CML patients -RSB- .
19099633	0	CD34	45,49	G-CSF	15,20	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY Expression|nmod|cells Expression|nmod|receptors receptors|amod|END_ENTITY	-LSB- Expression of G-CSF and GM-CSF receptors on CD34 positive cells in aplastic_anemia and myelodysplastic_syndrome patients and its significance -RSB- .
19294511	0	CD34	109,113	G-CSF	0,5	CD34	G-CSF	305081(Tax:10116)	25610(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY mobilization|nmod|cells associated|nmod|mobilization associated|nsubj|gradient gradient|amod|END_ENTITY	G-CSF enhanced SDF-1 gradient between bone marrow and liver associated with mobilization of peripheral blood CD34 + cells in rats with acute_liver_failure .
19746588	0	CD34	10,14	G-CSF	72,77	CD34	G-CSF	947	1440	Gene	Gene	+|nsubj|START_ENTITY +|nmod|delivery delivery|amod|END_ENTITY	Bi-phasic CD34 + cell mobilization of a syngeneic donor during prolonged G-CSF delivery .
19899124	0	CD34	101,105	G-CSF	22,27	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY yield|nmod|cells increases|dobj|yield use|advcl|increases use|nsubj|timing timing|nmod|END_ENTITY	Appropriate timing of G-CSF use after mobilization chemotherapy significantly increases the yield of CD34 + cells in autoPBSCT .
21392017	0	CD34	7,11	G-CSF	138,143	CD34	G-CSF	947	1440	Gene	Gene	dose|compound|START_ENTITY stem|nmod|dose stem|dobj|mobilization mobilization|dep|END_ENTITY	Beyond CD34 + cell dose : impact of method of peripheral blood hematopoietic stem cell mobilization -LRB- granulocyte-colony-stimulating_factor -LSB- G-CSF -RSB- , G-CSF plus plerixafor , or cyclophosphamide G-CSF/granulocyte-macrophage -LSB- GM -RSB- - CSF -RRB- on number of colony-forming unit-GM , engraftment , and Day +100 hematopoietic graft function .
21729566	0	CD34	10,14	G-CSF	67,72	CD34	G-CSF	947	1440	Gene	Gene	cells|amod|START_ENTITY Yield|nmod|cells increased|nsubjpass|Yield increased|nmod|END_ENTITY	-LSB- Yield of CD34 -LRB- + -RRB- cells in graft can be increased significantly by G-CSF used at appropriate time after chemotherapy for AutoPBSCT -RSB- .
22609881	0	CD34	54,58	G-CSF	77,82	CD34	G-CSF	947	1440	Gene	Gene	count|nummod|START_ENTITY associated|nsubjpass|count associated|dep|END_ENTITY	Extensive chronic_GVHD is associated with donor blood CD34 + cell count after G-CSF mobilization in non-myeloablative allogeneic PBSC transplantation .
23695795	0	CD34	21,25	G-CSF	111,116	CD34	G-CSF	947	1440	Gene	Gene	yield|nummod|START_ENTITY model|nmod|yield stem|nsubj|model stem|nmod|administration administration|amod|END_ENTITY	Prediction model for CD34 positive cell yield in peripheral blood stem cell collection on the fourth day after G-CSF administration in healthy donors .
23907769	0	CD34	93,97	G-CSF	44,49	CD34	G-CSF	947	1440	Gene	Gene	mobilization|nmod|START_ENTITY G-CSF|nmod|mobilization G-CSF|compound|END_ENTITY	Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34 -LRB- + -RRB- hematopoietic progenitor cells in patients > = 60 and < 60 years of age with non-Hodgkin 's _ lymphoma or multiple_myeloma .
23907769	0	CD34	93,97	G-CSF	67,72	CD34	G-CSF	947	1440	Gene	Gene	mobilization|nmod|START_ENTITY END_ENTITY|nmod|mobilization	Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34 -LRB- + -RRB- hematopoietic progenitor cells in patients > = 60 and < 60 years of age with non-Hodgkin 's _ lymphoma or multiple_myeloma .
24855532	0	CD34	28,32	G-CSF	81,86	CD34	G-CSF	12490(Tax:10090)	12985(Tax:10090)	Gene	Gene	Study|nmod|START_ENTITY Mobilized|nsubj|Study Mobilized|nmod|END_ENTITY	The Primary Study of CD90 -LRB- + -RRB- CD34 -LRB- - -RRB- and Sca-1 -LRB- + -RRB- Stem Cells Mobilized by EPO Plus G-CSF in Mice .
25663039	0	CD34	78,82	G-CSF	108,113	CD34	G-CSF	947	1440	Gene	Gene	efficiency|nmod|START_ENTITY predicting|dobj|efficiency level|acl|predicting use|nmod|level cell|nsubj|use cell|nmod|Mobilization Mobilization|compound|END_ENTITY	The use of hematocrit level for predicting the efficiency of peripheral blood CD34 -LRB- + -RRB- cell collection after G-CSF Mobilization in Healthy Donors .
25834108	0	CD34	16,20	G-CSF	0,5	CD34	G-CSF	947	1440	Gene	Gene	+|compound|START_ENTITY monocytes|nummod|+ mobilizes|dobj|monocytes mobilizes|nsubj|END_ENTITY	G-CSF mobilizes CD34 + regulatory monocytes that inhibit graft-versus-host_disease .
7535443	0	CD34	81,85	G-CSF	22,27	CD34	G-CSF	947	1440	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ collection|nmod|cells collection|advmod|prior prior|nmod:npmod|END_ENTITY	Administration of GM - / G-CSF prior to bone marrow harvest increases collection of CD34 + cells .
7542113	0	CD34	29,33	G-CSF	159,164	CD34	G-CSF	947	1440	Gene	Gene	Characterization|nmod|START_ENTITY +|nsubj|Characterization +|nmod|patients patients|acl|treated treated|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|appos|END_ENTITY	Characterization of enriched CD34 + cells from healthy volunteers and those from patients treated with chemotherapy plus granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
8602984	0	CD34	50,54	G-CSF	0,5	CD34	G-CSF	947	1440	Gene	Gene	cells|compound|START_ENTITY mobilizes|dobj|cells mobilizes|nsubj|END_ENTITY	G-CSF alone mobilizes sufficient peripheral blood CD34 + cells for positive selection in newly diagnosed patients with myeloma .
8950228	0	CD34	34,38	G-CSF	87,92	CD34	G-CSF	947	1440	Gene	Gene	+|compound|START_ENTITY subsets|nsubj|+ subsets|nmod|products products|acl|mobilized mobilized|nmod|GM-CSF GM-CSF|compound|END_ENTITY	Pluripotent and lineage-committed CD34 + subsets in leukapheresis products mobilized by G-CSF , GM-CSF vs. a combination of both .
9089980	0	CD34	38,42	G-CSF	16,21	CD34	G-CSF	947	1440	Gene	Gene	mobilization|nmod|START_ENTITY mobilization|amod|END_ENTITY	The kinetics of G-CSF mobilization of CD34 + cells in healthy people .
9136957	0	CD34	117,121	G-CSF	137,142	CD34	G-CSF	947	1440	Gene	Gene	cells|compound|START_ENTITY apoptotic|nmod|cells apoptotic|parataxis|role role|acl|END_ENTITY	G-CSF-mobilized CD34 peripheral blood stem cells are significantly less apoptotic than unstimulated peripheral blood CD34 cells : role of G-CSF as survival factor .
9136957	0	CD34	16,20	G-CSF	137,142	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY apoptotic|nsubj|cells apoptotic|parataxis|role role|acl|END_ENTITY	G-CSF-mobilized CD34 peripheral blood stem cells are significantly less apoptotic than unstimulated peripheral blood CD34 cells : role of G-CSF as survival factor .
9208494	0	CD34	67,71	G-CSF	91,96	CD34	G-CSF	947	1440	Gene	Gene	differentiation|nmod|START_ENTITY Promotion|nmod|differentiation +|nsubj|Promotion +|advcl|vitro vitro|nmod|END_ENTITY	Promotion of differentiation and proliferation of peripheral blood CD34 + cells in vitro by G-CSF .
9257810	0	CD34	51,55	G-CSF	116,121	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY cells|acl|purified purified|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|appos|END_ENTITY	Transduction of retrovirus-mediated NeoR gene into CD34 + cells purified from granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized infant and cord blood .
9261934	0	CD34	43,47	G-CSF	74,79	CD34	G-CSF	947	1440	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells Decrease|nmod|expression induced|nsubj|Decrease induced|nmod|mobilization mobilization|amod|END_ENTITY	Decrease in Thy-1 expression on peripheral CD34 positive cells induced by G-CSF mobilization .
9310126	0	CD34	16,20	G-CSF	64,69	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	Mobilization of CD34 + cells by glycosylated and nonglycosylated G-CSF in healthy volunteers -- a comparative study .
9377071	0	CD34	25,29	G-CSF	160,165	CD34	G-CSF	947	1440	Gene	Gene	maturation|nmod|START_ENTITY +|nsubj|maturation +|nmod|PIXY321 PIXY321|appos|END_ENTITY	Neutrophil maturation of CD34 + cells from peripheral blood and bone marrow in serum-free culture medium with PIXY321 and granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- .
9377072	0	CD34	44,48	G-CSF	91,96	CD34	G-CSF	947	1440	Gene	Gene	cells|compound|START_ENTITY culture|nmod|cells culture|dep|amplification amplification|nmod|progenitors progenitors|nmod|blood blood|amod|END_ENTITY	Animal serum-free culture of purified human CD34 + cells : amplification of progenitors from G-CSF and GM-CSF-mobilized peripheral blood .
9433467	0	CD34	14,18	G-CSF	40,45	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY cells|acl|isolated isolated|nmod|END_ENTITY	IL-13 induces CD34 + cells isolated from G-CSF mobilized blood to differentiate in vitro into potent antigen presenting cells .
9497891	0	CD34	84,88	G-CSF	68,73	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY mobilized|dobj|cells mobilized|nsubj|Analysis Analysis|nmod|recovery recovery|nmod|transplantation transplantation|nmod|END_ENTITY	Analysis of platelet recovery after autologous transplantation with G-CSF mobilized CD34 + cells purified from leukapheresis products .
9535034	0	CD34	153,157	G-CSF	55,60	CD34	G-CSF	947	1440	Gene	Gene	content|compound|START_ENTITY transplantation|nmod|content modified|dobj|transplantation modified|nsubj|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|appos|END_ENTITY	T cell-depleted granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- modified allogenic bone marrow transplantation for hematological_malignancy improves graft CD34 + cell content but is associated with delayed pancytopenia .
9543059	0	CD34	0,4	G-CSF	149,154	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY different|nsubj|cells different|nmod|cells cells|acl|mobilized mobilized|nmod|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9543059	0	CD34	0,4	G-CSF	85,90	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY cells|appos|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9543059	0	CD34	124,128	G-CSF	149,154	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY cells|acl|mobilized mobilized|nmod|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9543059	0	CD34	124,128	G-CSF	85,90	CD34	G-CSF	947	1440	Gene	Gene	cells|nummod|START_ENTITY different|nmod|cells different|nsubj|cells cells|appos|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9603397	0	CD34	29,33	G-CSF	95,100	CD34	G-CSF	947	1440	Gene	Gene	cells|compound|START_ENTITY Analysis|nmod|cells mobilized|nsubj|Analysis mobilized|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|appos|END_ENTITY	Analysis of peripheral blood CD34 + cells mobilized with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- using a long-term culture system .
18637807	0	CD34	58,62	G-CSFR	24,30	CD34	G-CSFR	947	1441	Gene	Gene	expressions|nmod|START_ENTITY expressions|compound|END_ENTITY	Comparative analysis of G-CSFR and GM-CSFR expressions on CD34 + cells in patients with aplastic_anemia and myelodysplastic_syndrome .
10848795	0	CD34	77,81	G-CSF_receptor	24,38	CD34	G-CSF receptor	947	1441	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Exclusive expression of G-CSF_receptor on myeloid progenitors in bone marrow CD34 + cells .
7533100	0	CD34	77,81	G-CSF_receptor	51,65	CD34	G-CSF receptor	947	1441	Gene	Gene	progenitors|compound|START_ENTITY progenitors|amod|END_ENTITY	High-frequency granuloid colony-forming ability of G-CSF_receptor possessing CD34 antigen positive human umbilical cord blood hematopoietic progenitors .
21614864	0	CD34	104,108	GATA-1	94,100	CD34	GATA-1	947	2623	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|nmod|cells	Simulated microgravity , erythroid differentiation , and the expression of transcription factor GATA-1 in CD34 + cells .
23028422	0	CD34	92,96	GATA-2	76,82	CD34	GATA-2	947	2624	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34 + hematopoietic cells .
20888805	0	CD34	70,74	GDNF	24,28	CD34	GDNF	947	2668	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Intravenous infusion of GDNF gene-modified human umbilical cord blood CD34 + cells protects against cerebral_ischemic_injury in spontaneously hypertensive rats .
25730818	0	CD34	120,124	Granulocyte_Colony-Stimulating_Factor	70,107	CD34	Granulocyte Colony-Stimulating Factor	947	1440	Gene	Gene	Associated|nmod|START_ENTITY Associated|nmod|Potential Potential|nmod|Receptor Receptor|compound|END_ENTITY	miR-155 Is Associated with the Leukemogenic Potential of the Class IV Granulocyte_Colony-Stimulating_Factor Receptor in CD34 -LRB- + -RRB- Progenitor Cells .
10905051	0	CD34	108,112	Granulocyte_colony-stimulating_factor	0,37	CD34	Granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells modulation|acl|circulating modulation|compound|END_ENTITY	Granulocyte_colony-stimulating_factor and lineage-independent modulation of VLA-4 expression on circulating CD34 + cells .
12100131	0	CD34	89,93	Granulocyte_colony-stimulating_factor	0,37	CD34	Granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|compound|START_ENTITY containing|nmod|cells blood|acl|containing graft|nsubj|blood mobilized|ccomp|graft mobilized|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor mobilized whole blood containing over 0.3 x 106/kg CD34 + cells is a sufficient graft in autologous transplantation for relapsed non-Hodgkin 's _ lymphoma .
12542495	0	CD34	88,92	Granulocyte_colony-stimulating_factor	0,37	CD34	Granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|nummod|START_ENTITY upregulates|nmod|cells upregulates|nsubj|administration administration|compound|END_ENTITY	Granulocyte_colony-stimulating_factor administration upregulates telomerase activity in CD34 + haematopoietic cells and may prevent telomere attrition after chemotherapy .
15377480	0	CD34	55,59	Granulocyte_colony-stimulating_factor	0,37	CD34	Granulocyte colony-stimulating factor	947	1440	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Granulocyte_colony-stimulating_factor after autologous CD34 + immunoselected peripheral blood stem cell transplantation .
22119930	0	CD34	48,52	Granulocyte_colony-stimulating_factor	0,37	CD34	Granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|amod|START_ENTITY mobilizes|dobj|cells mobilizes|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor mobilizes CD34 -LRB- + -RRB- cells and improves survival of patients with acute-on-chronic_liver_failure .
24056818	0	CD34	109,113	Granulocyte_colony-stimulating_factor	0,37	CD34	Granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|nummod|START_ENTITY produces|nmod|cells produces|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor produces long-term changes in gene and microRNA expression profiles in CD34 + cells from healthy donors .
8704221	0	CD34	53,57	Granulocyte_colony-stimulating_factor	0,37	CD34	Granulocyte colony-stimulating factor	947	1440	Gene	Gene	progenitors|nummod|START_ENTITY recruitment|nmod|progenitors recruitment|amod|END_ENTITY	Granulocyte_colony-stimulating_factor recruitment of CD34 + progenitors to peripheral blood : impaired mobilization in chronic_granulomatous_disease and adenosine_deaminase -- deficient severe_combined_immunodeficiency_disease patients .
12406897	0	CD34	112,116	HOXB4	19,24	CD34	HOXB4	947	3214	Gene	Gene	cells|compound|START_ENTITY advantage|nmod|cells confers|nmod|advantage confers|nsubj|expression expression|compound|END_ENTITY	High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34 + cells , but impairs lymphomyeloid differentiation .
14529835	0	CD34	86,90	HOXB4	50,55	CD34	HOXB4	947	3214	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34 + cells promotes myeloid differentiation but not proliferation .
16801129	0	CD34	73,77	HOXB4	122,127	CD34	HOXB4	947	3214	Gene	Gene	cells|compound|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	Stromal cells selectively reduce the growth advantage of human committed CD34 + hematopoietic cells ectopically expressing HOXB4 .
19549386	0	CD34	81,85	HOXB4	56,61	CD34	HOXB4	947	3214	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	-LSB- Analysis on promoter CpG methylation and expression of HOXB4 gene in cord blood CD34 -LRB- + -RRB- cells and peripheral blood mononuclear cells -RSB- .
23028422	0	CD34	92,96	HOXB4	37,42	CD34	HOXB4	947	3214	Gene	Gene	cells|compound|START_ENTITY GATA-2|nmod|cells target|nmod|GATA-2 END_ENTITY|nmod|target	Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34 + hematopoietic cells .
16129046	0	CD34	77,81	IL-15	11,16	CD34	IL-15	947	3600	Gene	Gene	proliferation|nmod|START_ENTITY END_ENTITY|nmod|proliferation	-LSB- Effect of IL-15 on the proliferation , differentiation and anti-apoptosis of CD34 + cells in patients with MDS -RSB- .
10460616	0	CD34	42,46	IL-3	113,117	CD34	IL-3	947	3562	Gene	Gene	cells|nummod|START_ENTITY adhesion|nmod|cells adhesion|dep|influence influence|nmod|END_ENTITY	alpha4beta1 integrin-mediated adhesion of CD34 + cells from patients with chronic_myeloid_leukaemia : influence of IL-3 .
10527461	0	CD34	75,79	IL-3	20,24	CD34	IL-3	947	3562	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Correlation between IL-3 receptor expression and growth potential of human CD34 + hematopoietic cells from different tissues .
10946261	0	CD34	63,67	IL-3	0,4	CD34	IL-3	947	3562	Gene	Gene	CD38|compound|START_ENTITY lymphoid|nmod|CD38 lymphoid|nsubj|production production|compound|END_ENTITY	IL-3 increases production of B lymphoid progenitors from human CD34 + CD38 - cells .
12002675	0	CD34	96,100	IL-3	23,27	CD34	IL-3	947	3562	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells influence|nmod|proliferation influence|nsubj|FLT3L FLT3L|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
12681965	0	CD34	67,71	IL-3	46,50	CD34	IL-3	947	3562	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ expansion|nmod|cells induced|nmod|expansion induced|nmod|END_ENTITY	IL-6 precludes the differentiation induced by IL-3 on expansion of CD34 + cells from cord blood .
15564141	0	CD34	71,75	IL-3	0,4	CD34	IL-3	947	3562	Gene	Gene	cells|compound|START_ENTITY efficiency|nmod|cells ex|dobj|efficiency ex|nsubj|increases increases|compound|END_ENTITY	IL-3 or IL-7 increases ex vivo gene transfer efficiency in ADA-SCID BM CD34 + cells while maintaining in vivo lymphoid potential .
23040055	0	CD34	42,46	IL-3	113,117	CD34	IL-3	947	3562	Gene	Gene	cells|compound|START_ENTITY macrophages|nmod|cells development|nmod|macrophages optimized|nsubjpass|development optimized|nmod|END_ENTITY	The development of macrophages from human CD34 + haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF .
2467703	0	CD34	81,85	IL-3	41,45	CD34	IL-3	947	3562	Gene	Gene	proliferation|nmod|START_ENTITY effects|nmod|proliferation effects|nmod|END_ENTITY	Combined and sequential effects of human IL-3 and GM-CSF on the proliferation of CD34 + hematopoietic cells from cord blood .
2475184	0	CD34	139,143	IL-3	113,117	CD34	IL-3	947	3562	Gene	Gene	characterization|nmod|START_ENTITY progenitors|dep|characterization progenitors|acl|cultured cultured|nmod|END_ENTITY	Sequential loss of CD34 and class II MHC antigens on purified cord blood hematopoietic progenitors cultured with IL-3 : characterization of CD34 - , HLA-DR + cells .
2475184	0	CD34	19,23	IL-3	113,117	CD34	IL-3	947	3562	Gene	Gene	loss|nmod|START_ENTITY HLA-DR|nsubj|loss HLA-DR|parataxis|antigens antigens|dobj|progenitors progenitors|acl|cultured cultured|nmod|END_ENTITY	Sequential loss of CD34 and class II MHC antigens on purified cord blood hematopoietic progenitors cultured with IL-3 : characterization of CD34 - , HLA-DR + cells .
7515297	0	CD34	57,61	IL-3	41,45	CD34	IL-3	947	3562	Gene	Gene	+|compound|START_ENTITY subsets|nummod|+ expand|dobj|subsets expand|nsubj|c-kit_ligand c-kit_ligand|nmod|END_ENTITY	c-kit_ligand combined with GM-CSF and/or IL-3 can expand CD34 + hematopoietic progenitor subsets for several weeks in vitro .
7520393	0	CD34	136,140	IL-3	82,86	CD34	IL-3	947	3562	Gene	Gene	cells|nummod|START_ENTITY stimulated|dobj|cells IL-1|acl|stimulated status|dep|IL-1 status|nmod|interleukin-3 interleukin-3|appos|END_ENTITY	Transforming_growth_factor-beta regulates the cell cycle status of interleukin-3 -LRB- IL-3 -RRB- plus IL-1 , stem_cell_factor , or IL-6 stimulated CD34 + human hematopoietic progenitor cells through different cell kinetic mechanisms depending on the applied stimulus .
7685706	0	CD34	84,88	IL-4	72,76	CD34	IL-4	947	3565	Gene	Gene	subset|compound|START_ENTITY END_ENTITY|nmod|subset	Effects of interleukin-4 on myelopoiesis : localization of the action of IL-4 in the CD34 + HLA-DR + + subset and distinction between direct and indirect effects of IL-4 .
10584413	0	CD34	64,68	IL-5	16,20	CD34	IL-5	947	3567	Gene	Gene	cells|nummod|START_ENTITY marrow-derived|dobj|cells marrow-derived|nsubj|Upregulation Upregulation|nmod|expression expression|compound|END_ENTITY	Upregulation of IL-5 receptor expression on bone marrow-derived CD34 + cells from patients with asthma .
15355467	0	CD34	32,36	IL-5	57,61	CD34	IL-5	12490(Tax:10090)	16191(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY stimulates|dobj|cells stimulates|advcl|release release|xcomp|END_ENTITY	Allergen stimulates bone marrow CD34 -LRB- + -RRB- cells to release IL-5 in vitro ; a mechanism involved in eosinophilic_inflammation ?
19968630	0	CD34	39,43	IL-5	0,4	CD34	IL-5	947	3567	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	IL-5 expression and release from human CD34 cells in vitro ; ex vivo evidence from cases of asthma and Churg-Strauss_syndrome .
9831865	0	CD34	143,147	IL-5	67,71	CD34	IL-5	947	3567	Gene	Gene	hematopoietic|compound|START_ENTITY differentiation|nmod|hematopoietic proteins|nmod|differentiation proteins|nmod|END_ENTITY	Differential activation of functionally distinct STAT5 proteins by IL-5 and GM-CSF during eosinophil and neutrophil differentiation from human CD34 + hematopoietic stem cells .
14630618	0	CD34	7,11	IL-5Ralpha	12,22	CD34	IL-5Ralpha	947	3568	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Sputum CD34 + IL-5Ralpha + cells increase after allergen : evidence for in situ eosinophilopoiesis .
17591359	0	CD34	59,63	IL-6	40,44	CD34	IL-6	947	3569	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|compound|END_ENTITY	Head_and_neck_cancer triggers increased IL-6 production of CD34 + stem cells from human cord blood .
22005288	0	CD34	115,119	ILT3	82,86	CD34	ILT3	947	11006	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
1375107	0	CD34	74,78	Interferon-gamma	0,16	CD34	Interferon-gamma	947	3458	Gene	Gene	hematopoietic_progenitor_cells|compound|START_ENTITY proliferation|nmod|hematopoietic_progenitor_cells enhances|dobj|proliferation enhances|nsubj|END_ENTITY	Interferon-gamma enhances factor-dependent myeloid proliferation of human CD34 + hematopoietic_progenitor_cells .
8839847	0	CD34	72,76	Interleukin-10	0,14	CD34	Interleukin-10	947	3586	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-10 increases Bcl-2 expression and survival in primary human CD34 + hematopoietic progenitor cells .
20378847	0	CD34	50,54	Junctional_adhesion_molecule_A	0,30	CD34	Junctional adhesion molecule A	947	50848	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells END_ENTITY|acl|expressed	Junctional_adhesion_molecule_A expressed on human CD34 + cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells .
12763212	0	CD34	52,56	K-ras	27,32	CD34	K-ras	947	3845	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
19170841	0	CD34	12,16	KDR	18,21	CD34	KDR	947	3791	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD34 + KDR + endothelial progenitor cells correlate with erectile function and endothelial function in overweight men .
19173675	0	CD34	12,16	KDR	18,21	CD34	KDR	947	3791	Gene	Gene	+|compound|START_ENTITY Circulating|dobj|+ +|dep|Circulating +|compound|END_ENTITY	Circulating CD34 + / KDR + endothelial progenitor cells are reduced in chronic_heart_failure patients as a function of Type_D personality .
21030714	0	CD34	54,58	KDR	12,15	CD34	KDR	947	3791	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells generated|advcl|circulating generated|nsubjpass|cells cells|compound|END_ENTITY	Human CD34 + / KDR + cells are generated from circulating CD34 + cells after immobilization on activated platelets .
21030714	0	CD34	6,10	KDR	12,15	CD34	KDR	947	3791	Gene	Gene	+|compound|START_ENTITY +|parataxis|generated generated|nsubjpass|cells cells|compound|END_ENTITY	Human CD34 + / KDR + cells are generated from circulating CD34 + cells after immobilization on activated platelets .
21543296	0	CD34	30,34	KDR	35,38	CD34	KDR	947	3791	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial progenitor cells -LRB- CD34 + KDR + -RRB- and monocytes may provide the development of good coronary collaterals despite the vascular risk factors and extensive atherosclerosis .
22805118	0	CD34	16,20	KDR	22,25	CD34	KDR	947	3791	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Mobilization of CD34 + KDR + endothelial progenitor cells predicts target_lesion revascularization .
22855739	0	CD34	28,32	KDR	34,37	CD34	KDR	947	3791	Gene	Gene	START_ENTITY|dep|cells cells|dep|END_ENTITY	Osteocalcin positive CD133 + / CD34 - / KDR + progenitor cells as an independent marker for unstable atherosclerosis .
23171577	0	CD34	30,34	KDR	36,39	CD34	KDR	947	3791	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Quantification of circulating CD34 + / KDR + / CD45dim endothelial progenitor cells : analytical considerations .
23383116	0	CD34	19,23	KDR	25,28	CD34	KDR	305081(Tax:10116)	25589(Tax:10116)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Analysis of CD45 - -LSB- CD34 + / KDR + -RSB- endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic_stroke .
23895310	0	CD34	58,62	KDR	99,102	CD34	KDR	947	3791	Gene	Gene	cells|compound|START_ENTITY mobilization|nmod|cells correlate|nmod|mobilization platelets|acl:relcl|correlate platelets|dep|END_ENTITY	Activated platelets correlate with mobilization of na ve CD34 -LRB- + -RRB- cells and generation of CD34 -LRB- + -RRB- / KDR -LRB- + -RRB- cells in the circulation .
24365195	0	CD34	22,26	KDR	28,31	CD34	KDR	947	3791	Gene	Gene	+|compound|START_ENTITY circulating|dobj|+ Levels|acl|circulating Levels|parataxis|predict predict|nsubj|cells cells|compound|END_ENTITY	Levels of circulating CD34 + / KDR + cells do not predict coronary_in-stent_restenosis .
10367780	0	CD34	47,51	L-selectin	0,10	CD34	L-selectin	947	6402	Gene	Gene	progenitors|compound|START_ENTITY clonogenesis|nmod|progenitors enhances|dobj|clonogenesis enhances|nsubj|expression expression|amod|END_ENTITY	L-selectin expression enhances clonogenesis of CD34 + cord blood progenitors .
10435581	0	CD34	128,132	L-selectin	97,107	CD34	L-selectin	947	6402	Gene	Gene	displayed|nmod|START_ENTITY ligand|acl|displayed ligand|amod|END_ENTITY	A novel , high endothelial venule-specific sulfotransferase expresses 6-sulfo_sialyl Lewis -LRB- x -RRB- , an L-selectin ligand displayed by CD34 .
10681720	0	CD34	32,36	L-selectin	0,10	CD34	L-selectin	947	6402	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ low|nmod|cells expression|advmod|low expression|nsubj|expression expression|amod|END_ENTITY	L-selectin expression is low on CD34 + cells from patients with chronic_myeloid_leukemia and interferon-a up-regulates this expression .
11164112	0	CD34	43,47	L-selectin	12,22	CD34	L-selectin	947	6402	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Decrease of L-selectin expression on human CD34 + cells on freeze-thawing and rapid recovery with short-term incubation .
11895802	0	CD34	36,40	L-selectin	69,79	CD34	L-selectin	947	6402	Gene	Gene	O-glycans|nmod|START_ENTITY putatively|nsubj|O-glycans putatively|xcomp|participating participating|nmod|recognition recognition|amod|END_ENTITY	O-glycans on human high endothelial CD34 putatively participating in L-selectin recognition .
12063026	0	CD34	35,39	L-selectin	83,93	CD34	L-selectin	947	6402	Gene	Gene	cells|amod|START_ENTITY outgrowth|nmod|cells outgrowth|dep|role role|nmod|END_ENTITY	Homing and clonogenic outgrowth of CD34 -LRB- + -RRB- peripheral blood stem cells : a role for L-selectin ?
12889478	0	CD34	28,32	L-selectin	57,67	CD34	L-selectin	947	6402	Gene	Gene	family|compound|START_ENTITY member|nmod|family Endoglycan|appos|member functions|nsubj|Endoglycan functions|advcl|ligand ligand|nsubj|END_ENTITY	Endoglycan , a member of the CD34 family , functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x .
17765649	0	CD34	22,26	L-selectin	181,191	CD34	L-selectin	947	6402	Gene	Gene	+|compound|START_ENTITY Mobilization|nmod|+ stem|nsubj|Mobilization stem|nmod|consumption consumption|nmod|expression expression|nmod|ligand ligand|amod|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
19359410	0	CD34	32,36	L-selectin	47,57	CD34	L-selectin	947	6402	Gene	Gene	START_ENTITY|ccomp|carry carry|nsubj|END_ENTITY	Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O - and N-glycans .
7522633	0	CD34	37,41	L-selectin	84,94	CD34	L-selectin	12490(Tax:10090)	20343(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY ligand|nsubj|expression ligand|nmod|END_ENTITY	Global vascular expression of murine CD34 , a sialomucin-like endothelial ligand for L-selectin .
7538823	0	CD34	36,40	L-selectin	55,65	CD34	L-selectin	947	6402	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ molecules|nmod|cells Expression|nmod|molecules Expression|dep|END_ENTITY	Expression of adhesion molecules on CD34 + cells : CD34 + L-selectin + cells predict a rapid platelet recovery after peripheral blood stem cell transplantation .
7692600	0	CD34	49,53	L-selectin	11,21	CD34	L-selectin	947	6402	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of L-selectin to the vascular sialomucin CD34 .
8542944	0	CD34	59,63	L-selectin	27,37	CD34	L-selectin	947	6402	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of L-selectin , VLA-4 , and LFA-1 on CD34 + progenitor cells from bone_marrow and peripheral blood during G-CSF-enhanced recovery .
9134437	0	CD34	58,62	L-selectin	95,105	CD34	L-selectin	947	6402	Gene	Gene	glycoform|nmod|START_ENTITY requirements|nmod|glycoform ligand|nsubj|requirements ligand|nmod|END_ENTITY	Sulfation and sialylation requirements for a glycoform of CD34 , a major endothelial ligand for L-selectin in porcine peripheral lymph nodes .
9517512	0	CD34	25,29	L-selectin	0,10	CD34	L-selectin	947	6402	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	L-selectin expression in CD34 positive cells in chronic myeloid_leukemia .
9625756	0	CD34	108,112	L-selectin	83,93	CD34	L-selectin	947	6402	Gene	Gene	parallels|nmod|START_ENTITY Identification|dep|parallels Identification|nmod|podocalyxin-like_protein podocalyxin-like_protein|nmod|venule venule|acl|ligand ligand|nmod|END_ENTITY	Identification of podocalyxin-like_protein as a high endothelial venule ligand for L-selectin : parallels to CD34 .
11399626	0	CD34	34,38	LFA-1	14,19	CD34	LFA-1	947	3683	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	Regulation of LFA-1 Expression by CD34 Positive Cells and Inducible Growth Factor Production by Stroma Enable Formation of Bone Marrow Compartments ; Subject Heading .
12847234	0	CD34	111,115	LFA-1	28,33	CD34	LFA-1	947	3683	Gene	Gene	Lin|compound|START_ENTITY required|nmod|Lin step|acl|required step|nsubj|induction induction|nmod|END_ENTITY	IL-15-mediated induction of LFA-1 is a late step required for cytotoxic differentiation of human NK cells from CD34 + Lin - bone marrow cells .
1378320	0	CD34	124,128	LFA-1	130,135	CD34	LFA-1	947	3683	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
1378320	0	CD34	124,128	LFA-1	87,92	CD34	LFA-1	947	3683	Gene	Gene	cells|compound|START_ENTITY primitive|nmod|cells primitive|nsubj|Expression Expression|nmod|molecules molecules|nmod|cells cells|dep|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
1378320	0	CD34	81,85	LFA-1	130,135	CD34	LFA-1	947	3683	Gene	Gene	LFA-1|compound|START_ENTITY cells|dep|LFA-1 molecules|nmod|cells Expression|nmod|molecules primitive|nsubj|Expression primitive|nmod|cells cells|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
8639769	0	CD34	34,38	LFA-1	13,18	CD34	LFA-1	947	3683	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Induction of LFA-1 on pluripotent CD34 + bone marrow cells does not affect lineage commitment .
7536684	0	CD34	145,149	MIP-1_alpha	53,64	CD34	MIP-1 alpha	947	6348	Gene	Gene	cells|nummod|START_ENTITY subpopulations|nmod|cells proliferation|nmod|subpopulations inhibitors|nmod|proliferation inhibitors|dobj|END_ENTITY	Differential effects of the hematopoietic inhibitors MIP-1_alpha , TGF-beta , and TNF-alpha on cytokine-induced proliferation of subpopulations of CD34 + cells purified from cord blood and fetal liver .
7539383	0	CD34	103,107	MIP-1_alpha	72,83	CD34	MIP-1 alpha	947	6348	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Comparison of the inhibitory effect of AcSDKP , TNF-alpha , TGF-beta , and MIP-1_alpha on marrow-purified CD34 + progenitors .
9766815	0	CD34	25,29	MIP-1_alpha	81,92	CD34	MIP-1 alpha	947	6348	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ response|nmod|cells isolated|nsubj|response isolated|nmod|blood blood|nmod|END_ENTITY	Differential response of CD34 + cells isolated from cord blood and bone marrow to MIP-1_alpha and the expression of MIP-1_alpha receptors on these immature cells .
24305990	0	CD34	31,35	MMP-9	13,18	CD34	MMP-9	947	4318	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Differential MMP-9 activity in CD34 -LRB- + -RRB- progenitor cell-derived foam cells from diabetic and normoglycemic patients .
10229864	0	CD34	98,102	Macrophage-inflammatory_protein-1alpha_receptor	0,47	CD34	Macrophage-inflammatory protein-1alpha receptor	947	1230	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Macrophage-inflammatory_protein-1alpha_receptor expression on normal and chronic_myeloid_leukemia CD34 + cells .
23736775	0	CD34	97,101	MafA	89,93	CD34	MafA	947	389692	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	A Short-activating RNA Oligonucleotide Targeting the Islet b-cell Transcriptional Factor MafA in CD34 -LRB- + -RRB- Cells .
7691248	0	CD34	30,34	Myeloperoxidase	0,15	CD34	Myeloperoxidase	947	4353	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Myeloperoxidase expression in CD34 + normal human hematopoietic cells .
20444543	0	CD34	42,46	N-Cadherin	14,24	CD34	N-Cadherin	947	1000	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Enrichment of N-Cadherin and Tie2-bearing CD34 + / CD38 - / CD123 + leukemic stem cells by chemotherapy-resistance .
12031911	0	CD34	78,82	P-glycoprotein	51,65	CD34	P-glycoprotein	947	5243	Gene	Gene	cells|nummod|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Influence of functional MDR1 gene polymorphisms on P-glycoprotein activity in CD34 + hematopoietic stem cells .
12100168	0	CD34	63,67	P-glycoprotein	45,59	CD34	P-glycoprotein	947	5243	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Reduced function of the multidrug resistance P-glycoprotein in CD34 + cells of patients with aplastic_anaemia .
8562416	0	CD34	112,116	P-glycoprotein	11,25	CD34	P-glycoprotein	947	5243	Gene	Gene	antigen|compound|START_ENTITY expression|nmod|antigen Studies|dep|expression Studies|nmod|END_ENTITY	Studies of P-glycoprotein in chronic myelogenous_leukaemia patients : expression , activity and correlations with CD34 antigen .
26619102	0	CD34	21,25	PARP-1	0,6	CD34	PARP-1	947	142	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ expression|nmod|cells expression|compound|END_ENTITY	PARP-1 expression in CD34 + leukemic cells in childhood acute_lymphoblastic_leukemia : relation to response to initial therapy and other prognostic factors .
12763212	0	CD34	52,56	PCNA	46,50	CD34	PCNA	947	5111	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
7540608	0	CD34	125,129	Ph1	119,122	CD34	Ph1	12490(Tax:10090)	189	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Direct transplantation of chronic_myelogenous_leukemia cells into nude_mice and establishment of a leukemic stem cell -LRB- Ph1 + , CD34 + -RRB- line dependent on mouse bone marrow stromal cells in vitro .
10527462	0	CD34	155,159	SCF	95,98	CD34	SCF	947	4254	Gene	Gene	proliferation|compound|START_ENTITY resulted|nmod|proliferation resulted|nsubj|reduction reduction|nmod|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	The reduction of in vitro radiation-induced Fas-related apoptosis in CD34 + progenitor cells by SCF , FLT-3_ligand , TPO , and IL-3 in combination resulted in CD34 + cell proliferation and differentiation .
10527462	0	CD34	69,73	SCF	95,98	CD34	SCF	947	4254	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	The reduction of in vitro radiation-induced Fas-related apoptosis in CD34 + progenitor cells by SCF , FLT-3_ligand , TPO , and IL-3 in combination resulted in CD34 + cell proliferation and differentiation .
11237067	0	CD34	23,27	SCF	142,145	CD34	SCF	947	4254	Gene	Gene	+|compound|START_ENTITY analysis|nmod|+ analysis|dep|subsets subsets|dep|mobilized mobilized|nmod|END_ENTITY	Sequential analysis of CD34 + and CD34 - cell subsets in peripheral blood and leukapheresis products from breast_cancer patients mobilized with SCF plus G-CSF and cyclophosphamide .
12002675	0	CD34	96,100	SCF	30,33	CD34	SCF	947	4254	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells influence|nmod|proliferation influence|nsubj|FLT3L FLT3L|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
12578718	0	CD34	47,51	SCF	77,80	CD34	SCF	947	4254	Gene	Gene	Cells|nmod|START_ENTITY Vitro|nmod|Cells -RSB-|nmod|Vitro -RSB-|nsubj|Stimulated Stimulated|nmod|END_ENTITY	-LSB- Expension In Vitro of T Cells from Cord Blood CD34 -LRB- + -RRB- Cells Stimulated with SCF and IL-2 -RSB- The generation of large quantities of novel human T cell clones ex vivo would make a wide range of gene-and immuno-therapies for tumor and AIDS possibly .
17971220	0	CD34	51,55	SCF	83,86	CD34	SCF	947	4254	Gene	Gene	neutrophils|nmod|START_ENTITY expansion|nmod|neutrophils +|nsubj|expansion +|nmod|combination combination|nmod|END_ENTITY	Optimal ex vivo expansion of neutrophils from PBSC CD34 + cells by a combination of SCF , Flt3-L and G-CSF and its inhibition by further addition of TPO .
12004084	0	CD34	18,22	SDF-1	136,141	CD34	SDF-1	947	6387	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|nmod|response response|nmod|END_ENTITY	Immature leukemic CD34 + CXCR4 + cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1 .
11209089	0	CD34	59,63	SDF-1_receptor	41,55	CD34	SDF-1 receptor	947	7852	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Plasma levels of SDF-1 and expression of SDF-1_receptor on CD34 + cells in mobilized peripheral blood of non-Hodgkin 's _ lymphoma patients .
12384143	0	CD34	139,143	STAT5	200,205	CD34	STAT5	947	6776	Gene	Gene	cells|compound|START_ENTITY cells|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Transforming_growth_factor-beta -LRB- 1 -RRB- augments granulocyte-macrophage_colony-stimulating_factor-induced proliferation of umbilical cord blood CD34 -LRB- + -RRB- cells with an associated tyrosine phosphorylation of STAT5 .
10634171	0	CD34	91,95	Sca-1	98,103	CD34	Sca-1	12490(Tax:10090)	110454(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|dep|+ +|compound|END_ENTITY	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
22448926	0	CD34	48,52	Semaphorin_7A	0,13	CD34	Semaphorin 7A	947	8482	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|nsubj|END_ENTITY	Semaphorin_7A inhibits platelet production from CD34 + progenitor cells .
10989198	0	CD34	14,18	Sp1	36,39	CD34	Sp1	12490(Tax:10090)	20683(Tax:10090)	Gene	Gene	transcription|nummod|START_ENTITY transcription|nmod|END_ENTITY	Regulation of CD34 transcription by Sp1 requires sites upstream and downstream of the transcription start site .
26505626	0	CD34	107,111	Stem_Cell_Factor	18,34	CD34	Stem Cell Factor	947	4254	Gene	Gene	Cells|compound|START_ENTITY Expansion|nmod|Cells Stimulating|dobj|Expansion Capable|acl|Stimulating Capable|nsubj|Residues Residues|nmod|Sequence Sequence|compound|END_ENTITY	Residues 39-56 of Stem_Cell_Factor Protein Sequence Are Capable of Stimulating the Expansion of Cord Blood CD34 + Cells .
11145659	0	CD34	103,107	Stem_cell_factor	0,16	CD34	Stem cell factor	947	4254	Gene	Gene	DR|compound|START_ENTITY expansion|nmod|DR sustain|dobj|expansion required|xcomp|sustain required|nsubjpass|END_ENTITY	Stem_cell_factor and FLT3-ligand are strictly required to sustain the long-term expansion of primitive CD34 + DR - dendritic cell precursors .
25899394	0	CD34	110,114	Stem_cell_factor	0,16	CD34	Stem cell factor	12490(Tax:10090)	17311(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expanded|dobj|cells vivo|acl|expanded capacity|nmod|vivo preserving|dobj|capacity essential|advcl|preserving essential|nsubj|END_ENTITY	Stem_cell_factor is essential for preserving NOD/SCID reconstitution capacity of ex vivo expanded cord blood CD34 -LRB- + -RRB- cells .
25899394	0	CD34	110,114	Stem_cell_factor	0,16	CD34	Stem cell factor	12490(Tax:10090)	17311(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expanded|dobj|cells vivo|acl|expanded capacity|nmod|vivo preserving|dobj|capacity essential|advcl|preserving essential|nsubj|END_ENTITY	Stem_cell_factor is essential for preserving NOD/SCID reconstitution capacity of ex vivo expanded cord blood CD34 -LRB- + -RRB- cells .
7520394	0	CD34	92,96	Stem_cell_factor	0,16	CD34	Stem cell factor	947	4254	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ enhances|dobj|proliferation enhances|nsubj|END_ENTITY	Stem_cell_factor -LRB- c-kit_ligand -RRB- enhances the interleukin-9-dependent proliferation of human CD34 + and CD34 + CD33-DR - cells .
9746786	0	CD34	144,148	Stem_cell_factor	0,16	CD34	Stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY fraction|nmod|cells proliferation|nmod|fraction induces|dobj|proliferation induces|nsubj|END_ENTITY	Stem_cell_factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic_myeloid_leukemia CD34 -LRB- + -RRB- cells .
8760823	0	CD34	0,4	TNF_alpha	136,145	CD34	TNF alpha	947	7124	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	CD34 + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF_alpha .
9286332	0	CD34	0,4	TNF_alpha	136,145	CD34	TNF alpha	947	7124	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	CD34 + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF_alpha .
15731354	0	CD34	67,71	TRKA	37,41	CD34	TRKA	947	4914	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34 + cells , allowing nerve_growth_factor-induced expansion .
10378888	0	CD34	0,4	Thy-1	102,107	CD34	Thy-1	947	7070	Gene	Gene	cells|nummod|START_ENTITY retain|nsubj|cells retain|dobj|marrow marrow|acl|repopulating repopulating|nmod|subset subset|amod|+ +|amod|END_ENTITY	CD34 + cells from mobilized peripheral blood retain fetal bone marrow repopulating capacity within the Thy-1 + subset following cell division ex vivo .
10378891	0	CD34	119,123	Thy-1	125,130	CD34	Thy-1	947	7070	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Thrombopoietin , flt3 , and kit ligands together suppress apoptosis of human mobilized CD34 + cells and recruit primitive CD34 + Thy-1 + cells into rapid division .
10557051	0	CD34	99,103	Thy-1	51,56	CD34	Thy-1	947	7070	Gene	Gene	subfractions|appos|START_ENTITY Detection|dep|subfractions Detection|nmod|aberrations aberrations|nmod|CD90 CD90|appos|END_ENTITY	Detection of cytogenetic aberrations both in CD90 -LRB- Thy-1 -RRB- - positive and -LRB- Thy-1 -RRB- - negative stem cell -LRB- CD34 -RRB- subfractions of patients with acute and chronic_myeloid_leukemias .
10634171	0	CD34	91,95	Thy-1	106,111	CD34	Thy-1	12490(Tax:10090)	21838(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|dep|+ +|appos|END_ENTITY	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
11313664	0	CD34	49,53	Thy-1	41,46	CD34	Thy-1	947	7070	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Transplantation of a fetus with paternal Thy-1 -LRB- + -RRB- CD34 -LRB- + -RRB- cells for chronic granulomatous_disease .
14662335	0	CD34	0,4	Thy-1	11,16	CD34	Thy-1	947	7070	Gene	Gene	CDw90|compound|START_ENTITY CDw90|appos|END_ENTITY	CD34 + CDw90 -LRB- Thy-1 -RRB- + subset colocated with mesenchymal progenitors in human normal bone marrow hematon units is enriched in colony-forming unit megakaryocytes and long-term culture-initiating cells .
15625845	0	CD34	32,36	Thy-1	38,43	CD34	Thy-1	947	7070	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	-LSB- The implication of circulating CD34 + Thy-1 -LRB- + -RRB- cells measurement during autologous peripheral blood stem cell mobilization -RSB- .
7475307	0	CD34	36,40	Thy-1	41,46	CD34	Thy-1	947	7070	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Cytokine-mobilized peripheral blood CD34 + Thy-1 + Lin - human hematopoietic stem cells as target cells for transplantation-based gene therapy .
7529060	0	CD34	60,64	Thy-1	65,70	CD34	Thy-1	947	7070	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Enrichment of human hematopoietic stem cell activity in the CD34 + Thy-1 + Lin - subpopulation from mobilized_peripheral_blood .
7540889	0	CD34	48,52	Thy-1	20,25	CD34	Thy-1	947	7070	Gene	Gene	acute_leukemia|compound|START_ENTITY Characterization|nmod|acute_leukemia Characterization|nmod|expression expression|compound|END_ENTITY	Characterization of Thy-1 -LRB- CDw90 -RRB- expression in CD34 + acute_leukemia .
8542956	0	CD34	25,29	Thy-1	30,35	CD34	Thy-1	947	7070	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Optimizing the CD34 + and CD34 + Thy-1 + stem cell content of peripheral blood collections .
8608259	0	CD34	17,21	Thy-1	68,73	CD34	Thy-1	12490(Tax:10090)	21838(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY differ|nsubj|cells differ|dobj|cells cells|nmod|expression expression|compound|END_ENTITY	Peripheral blood CD34 + cells differ from bone marrow CD34 + cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte_colony-stimulating_factor and/or stem_cell_factor .
8608259	0	CD34	53,57	Thy-1	68,73	CD34	Thy-1	12490(Tax:10090)	21838(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|expression expression|compound|END_ENTITY	Peripheral blood CD34 + cells differ from bone marrow CD34 + cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte_colony-stimulating_factor and/or stem_cell_factor .
8647230	0	CD34	18,22	Thy-1	83,88	CD34	Thy-1	101105675	101109906	Gene	Gene	+|compound|START_ENTITY Identification|nmod|+ subsets|nsubj|Identification subsets|advcl|stem stem|nsubj|selection selection|dep|engraftment engraftment|nmod|Lin Lin|compound|END_ENTITY	Identification of CD34 + subsets after glycoprotease selection : engraftment of CD34 + Thy-1 + Lin - stem cells in fetal sheep .
8647230	0	CD34	78,82	Thy-1	83,88	CD34	Thy-1	101105675	101109906	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Identification of CD34 + subsets after glycoprotease selection : engraftment of CD34 + Thy-1 + Lin - stem cells in fetal sheep .
8724526	0	CD34	0,4	Thy-1	5,10	CD34	Thy-1	947	7070	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	CD34 + Thy-1 + Lin - stem cells from mobilized_peripheral_blood .
8781417	0	CD34	114,118	Thy-1	119,124	CD34	Thy-1	947	7070	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Thrombopoietin stimulates megakaryocytopoiesis , myelopoiesis , and expansion of CD34 + progenitor cells from single CD34 + Thy-1 + Lin - primitive progenitor cells .
8781417	0	CD34	79,83	Thy-1	119,124	CD34	Thy-1	947	7070	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|Lin Lin|compound|END_ENTITY	Thrombopoietin stimulates megakaryocytopoiesis , myelopoiesis , and expansion of CD34 + progenitor cells from single CD34 + Thy-1 + Lin - primitive progenitor cells .
8943851	0	CD34	99,103	Thy-1	104,109	CD34	Thy-1	947	7070	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Transplantation and gene transfer of the human glucocerebrosidase gene into immunoselected primate CD34 + Thy-1 + cells .
9028155	0	CD34	29,33	Thy-1	8,13	CD34	Thy-1	947	7070	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|appos|END_ENTITY	-LSB- CDw90 -LRB- Thy-1 -RRB- expression on CD34 positive cells in peripheral blood stem cell harvest -RSB- .
9192752	0	CD34	55,59	Thy-1	61,66	CD34	Thy-1	947	7070	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Hematopoietic potential and retroviral transduction of CD34 + Thy-1 + peripheral blood stem cells from asymptomatic human_immunodeficiency_virus_type-1-infected individuals mobilized with granulocyte colony-stimulating factor .
9261934	0	CD34	43,47	Thy-1	12,17	CD34	Thy-1	947	7070	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Decrease in Thy-1 expression on peripheral CD34 positive cells induced by G-CSF mobilization .
9454750	0	CD34	133,137	Thy-1	138,143	CD34	Thy-1	947	7070	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Thrombopoietin , kit ligand , and flk2/flt3 _ ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34 + Thy-1 + Lin - cells with preserved ability to engraft SCID-hu bone .
9590653	0	CD34	65,69	Thy-1	70,75	CD34	Thy-1	947	7070	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	A neutralizing anti-TGF-beta1 antibody promotes proliferation of CD34 + Thy-1 + peripheral blood progenitors and increases the number of transduced progenitors .
23846855	0	CD34	84,88	Thy1	89,93	CD34	Thy1	947	7070	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	3-methylcholanthrene induces neurotoxicity in developing neurons derived from human CD34 + Thy1 + stem cells by activation of aryl_hydrocarbon_receptor .
25436985	0	CD34	54,58	Toll-like_receptor_3_and_interleukin_1b	0,39	CD34	Toll-like receptor 3 and interleukin 1b	947	7098;3553	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Toll-like_receptor_3_and_interleukin_1b expression in CD34 + cells from patients with rheumatoid_arthritis : association with inflammation and vascular involvement .
11840268	0	CD34	61,65	Transforming_growth_factor-beta1	0,32	CD34	Transforming growth factor-beta1	947	7040	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 transcriptionally activates CD34 and prevents induced differentiation of TF-1 cells in the absence of any cell-cycle effects .
11571308	0	CD34	98,102	Tumor_necrosis_factor-alpha	0,27	CD34	Tumor necrosis factor-alpha	947	7124	Gene	Gene	ligand|nmod|START_ENTITY cells|amod|ligand expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates the expression of inducible_costimulator_receptor ligand on CD34 -LRB- + -RRB- progenitor cells during differentiation into antigen presenting cells .
12423676	0	CD34	75,79	Tumor_necrosis_factor-alpha	0,27	CD34	Tumor necrosis factor-alpha	947	7124	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits generation of glycophorin A + cells by CD34 + cells .
1693526	0	CD34	147,151	Tumor_necrosis_factor-alpha	0,27	CD34	Tumor necrosis factor-alpha	947	7124	Gene	Gene	hematopoietic_progenitor_cells|compound|START_ENTITY proliferation|nmod|hematopoietic_progenitor_cells potentiates|dobj|proliferation potentiates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha strongly potentiates interleukin-3 and granulocyte-macrophage_colony-stimulating_factor-induced proliferation of human CD34 + hematopoietic_progenitor_cells .
12731667	0	CD34	108,112	Tunica_interna_endothelial_cell_kinase	0,38	CD34	Tunica interna endothelial cell kinase	947	7010	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Tunica_interna_endothelial_cell_kinase expression and hematopoietic and angiogenic potentials in cord blood CD34 + cells .
26107446	0	CD34	91,95	VEGF	76,80	CD34	VEGF	947	7422	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Study of novel coating strategy for coronary stents : simutaneous coating of VEGF and anti- CD34 antibody .
10648408	0	CD34	53,57	VEGFR-2	14,21	CD34	VEGFR-2	947	3791	Gene	Gene	circulating|dobj|START_ENTITY Expression|advcl|circulating Expression|nmod|END_ENTITY	Expression of VEGFR-2 and AC133 by circulating human CD34 -LRB- + -RRB- cells identifies a population of functional endothelial precursors .
16439688	0	CD34	0,4	VEGFR-2	13,20	CD34	VEGFR-2	947	3791	Gene	Gene	START_ENTITY|parataxis|+ +|dep|progenitor progenitor|compound|END_ENTITY	CD34 - / CD133 + / VEGFR-2 + endothelial progenitor cell subpopulation with potent vasoregenerative capacities .
17588480	0	CD34	6,10	VEGFR-2	17,24	CD34	VEGFR-2	947	3791	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD34 + AC133 + VEGFR-2 + cells are not endothelial progenitor cells but distinct , primitive hematopoietic progenitors .
18791450	0	CD34	51,55	VEGFR-2	57,64	CD34	VEGFR-2	947	3791	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Novel antibodies to the donor stem cell population CD34 + / VEGFR-2 + are associated with rejection after hematopoietic stem cell transplantation .
20360595	0	CD34	21,25	VEGFR-2	26,33	CD34	VEGFR-2	947	3791	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Maternal circulating CD34 + VEGFR-2 + and CD133 + VEGFR-2 + progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia .
22480576	0	CD34	40,44	VEGFR-2	45,52	CD34	VEGFR-2	947	3791	Gene	Gene	CD45|compound|START_ENTITY CD45|compound|END_ENTITY	Isolation and characterization of CD133 + CD34 + VEGFR-2 + CD45 - fetal endothelial cells from human term placenta .
12393704	0	CD34	43,47	VEGFR-3	0,7	CD34	VEGFR-3	947	2324	Gene	Gene	cells|compound|START_ENTITY population|nmod|cells identify|dobj|population identify|nsubj|END_ENTITY	VEGFR-3 and CD133 identify a population of CD34 + lymphatic/vascular endothelial precursor cells .
24450475	0	CD34	0,4	VEGFR-3	6,13	CD34	VEGFR-3	947	2324	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD34 + VEGFR-3 + progenitor cells have a potential to differentiate towards lymphatic endothelial cells .
21386843	0	CD34	31,35	VEGFR2	38,44	CD34	VEGFR2	947	3791	Gene	Gene	Levels|nmod|START_ENTITY END_ENTITY|nsubj|Levels	Levels of circulating CD45 -LRB- dim -RRB- CD34 -LRB- + -RRB- VEGFR2 -LRB- + -RRB- progenitor cells correlate with outcome in metastatic_renal_cell_carcinoma patients treated with tyrosine kinase inhibitors .
10828007	0	CD34	86,90	VLA-5	62,67	CD34	VLA-5	947	3678	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	The chemokine SDF-1 activates the integrins LFA-1 , VLA-4 , and VLA-5 on immature human CD34 -LRB- + -RRB- cells : role in transendothelial/stromal migration and engraftment of NOD/SCID mice .
10836206	0	CD34	57,61	VLA-5	30,35	CD34	VLA-5	947	3678	Gene	Gene	cells|nummod|START_ENTITY adhesion|nmod|cells adhesion|compound|END_ENTITY	Interleukin-11 enhancement of VLA-5 mediated adhesion of CD34 + cells from cord blood to fibronectin is associated with the PI-3 kinase pathway .
12844400	0	CD34	40,44	angiotensin_II	11,25	CD34	angiotensin II	947	183	Gene	Gene	expansion|compound|START_ENTITY expansion|amod|END_ENTITY	-LSB- Effect of angiotensin_II on cord blood CD34 -LRB- + -RRB- cells expansion in vitro -RSB- .
15934300	0	CD34	39,43	angiotensin_II	10,24	CD34	angiotensin II	947	183	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of angiotensin_II on cord blood CD34 + cells expansion in vitro .
16928312	0	CD34	69,73	angiotensin_II	11,25	CD34	angiotensin II	947	183	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of angiotensin_II on differentiation of umbilical cord blood CD34 + cells into megakaryocytes -RSB- .
25328292	0	CD34	34,38	bFGF	75,79	CD34	bFGF	947	2247	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of CD34 and basic_fibroblast_growth_factor -LRB- bFGF -RRB- in oral_submucous_fibrosis .
10924092	0	CD34	51,55	bcl-2	27,32	CD34	bcl-2	947	596	Gene	Gene	homologs|nmod|START_ENTITY homologs|amod|END_ENTITY	Differential expression of bcl-2 homologs in human CD34 -LRB- + -RRB- hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells .
12763212	0	CD34	52,56	bcl-2	39,44	CD34	bcl-2	947	596	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
8826891	0	CD34	90,94	bcl-2	19,24	CD34	bcl-2	947	596	Gene	Gene	expression|compound|START_ENTITY Down-regulation|nmod|expression Down-regulation|nmod|blasts blasts|amod|END_ENTITY	Down-regulation of bcl-2 in AML blasts by all-trans_retinoic_acid and its relationship to CD34 antigen expression .
9447823	0	CD34	70,74	bcl-2	5,10	CD34	bcl-2	947	596	Gene	Gene	rate|compound|START_ENTITY correlates|nmod|rate correlates|nsubj|expression expression|amod|END_ENTITY	High bcl-2 expression in acute_myeloid_leukemia cells correlates with CD34 positivity and complete remission rate .
15539082	0	CD34	141,145	beta1-integrins	116,131	CD34	beta1-integrins	947	3688	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Phosphatidylinositol-3-kinase activation mediates proline-rich_tyrosine_kinase_2 phosphorylation and recruitment to beta1-integrins in human CD34 + cells .
21431918	0	CD34	29,33	c-KIT	23,28	CD34	c-KIT	947	3815	Gene	Gene	precursors|compound|START_ENTITY precursors|amod|END_ENTITY	High susceptibility of c-KIT + CD34 + precursors to prolonged doxorubicin exposure interferes with Langerhans cell differentiation in a human cell line model .
24897507	0	CD34	129,133	c-KIT	11,16	CD34	c-KIT	947	3815	Gene	Gene	progenitors|compound|START_ENTITY damage|nmod|progenitors Activating|nsubj|damage Activating|dobj|mutations mutations|amod|END_ENTITY	Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34 + hematopoietic progenitors .
9207416	0	CD34	78,82	c-KIT	84,89	CD34	c-KIT	947	3815	Gene	Gene	START_ENTITY|dep|cells cells|amod|END_ENTITY	Myelomonoblastic leukaemia cells carrying the PEBP2beta/MYH11 fusion gene are CD34 , c-KIT + immature cells .
7545021	0	CD34	118,122	c-Kit	125,130	CD34	c-Kit	947	3815	Gene	Gene	+|compound|START_ENTITY +|appos|cells cells|amod|END_ENTITY	Expression and physiologic significance of Kit ligand and stem cell tyrosine kinase-1 receptor ligand in normal human CD34 + , c-Kit + marrow cells .
9669840	0	CD34	73,77	c-Kit	118,123	CD34	c-Kit	947	3815	Gene	Gene	START_ENTITY|dobj|cells cells|acl|coexpressing coexpressing|dobj|levels levels|nmod|END_ENTITY	Phenotypic and functional characterization of mobilized peripheral blood CD34 + cells coexpressing different levels of c-Kit .
9827903	0	CD34	81,85	c-Kit	50,55	CD34	c-Kit	947	3815	Gene	Gene	antigens|nmod|START_ENTITY antigens|amod|END_ENTITY	All-trans-retinoic_acid up-regulates CD38 but not c-Kit antigens on human marrow CD34 + cells without recruitment into cell cycle .
10634171	0	CD34	91,95	c-kit	118,123	CD34	c-kit	12490(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|amod|END_ENTITY	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
11177593	0	CD34	64,68	c-kit	29,34	CD34	c-kit	947	3815	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Co-transduction of cDNAs for c-kit and steel_factor into single CD34 + cord blood cells further enhances the growth of erythroid and multipotential progenitors .
14667198	0	CD34	96,100	c-kit	15,20	CD34	c-kit	947	3815	Gene	Gene	CD38|compound|START_ENTITY transforming_growth_factor-beta|nmod|CD38 expression|nmod|transforming_growth_factor-beta expression|amod|END_ENTITY	Correlation of c-kit expression and cell cycle regulation by transforming_growth_factor-beta in CD34 + CD38 - human bone marrow cells .
1720696	0	CD34	20,24	c-kit	0,5	CD34	c-kit	947	3815	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	c-kit expression by CD34 + bone marrow progenitors and inhibition of response to recombinant human interleukin-3 following exposure to c-kit antisense oligonucleotides .
1720696	0	CD34	20,24	c-kit	134,139	CD34	c-kit	947	3815	Gene	Gene	expression|nmod|START_ENTITY +|nsubj|expression +|nmod|oligonucleotides oligonucleotides|amod|END_ENTITY	c-kit expression by CD34 + bone marrow progenitors and inhibition of response to recombinant human interleukin-3 following exposure to c-kit antisense oligonucleotides .
19421145	0	CD34	45,49	c-kit	25,30	CD34	c-kit	947	3815	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	PLZF-mediated control on c-kit expression in CD34 -LRB- + -RRB- cells and early erythropoiesis .
23104253	0	CD34	53,57	c-kit	58,63	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Mesenchymal stem cells promote a primitive phenotype CD34 + c-kit + in human cord blood-derived hematopoietic stem cells during ex vivo expansion .
24577437	0	CD34	28,32	c-kit	7,12	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ expression|nmod|cells expression|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
7522108	0	CD34	46,50	c-kit	37,42	CD34	c-kit	947	3815	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Expression of adhesion molecules and c-kit on CD34 + hematopoietic progenitor cells : comparison of cytokine-mobilized blood stem cells with normal bone marrow and peripheral blood .
7522632	0	CD34	131,135	c-kit	54,59	CD34	c-kit	947	3815	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
8701944	0	CD34	14,18	c-kit	20,25	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY +|nummod|+ +|amod|END_ENTITY	Deficiency of CD34 + c-kit + and CD34 +38 - hematopoietic precursors in aplastic_anemia after immunosuppressive treatment .
9074422	0	CD34	140,144	c-kit	146,151	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	Action of human interleukin-4 and stem_cell_factor on erythroid and mixed colony formation by peripheral blood-derived CD34 + c-kit -LRB- high -RRB- or CD34 + c-kit -LRB- low -RRB- cells .
9186537	0	CD34	94,98	c-kit	149,154	CD34	c-kit	947	3815	Gene	Gene	progenitors|compound|START_ENTITY expressing|nsubj|progenitors expressing|dobj|levels levels|nmod|protein protein|amod|END_ENTITY	Human FLT3_ligand acts on myeloid as well as multipotential progenitors derived from purified CD34 + blood progenitors expressing different levels of c-kit protein .
9402654	0	CD34	38,42	c-kit	13,18	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY Induction|nmod|+ Induction|nmod|molecules molecules|amod|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	CD34	38,42	c-kit	44,49	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY Induction|nmod|+ Induction|parataxis|cells cells|amod|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	CD34	38,42	c-kit	82,87	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY Induction|nmod|+ Induction|parataxis|cells cells|dep|cells cells|amod|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	CD34	76,80	c-kit	13,18	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY evidence|nmod|+ cells|dep|evidence Induction|parataxis|cells Induction|nmod|molecules molecules|amod|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	CD34	76,80	c-kit	44,49	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY evidence|nmod|+ cells|dep|evidence cells|amod|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	CD34	76,80	c-kit	82,87	CD34	c-kit	947	3815	Gene	Gene	+|compound|START_ENTITY evidence|nmod|+ cells|dep|evidence cells|dep|cells cells|amod|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
16267071	0	CD34	16,20	c-met	45,50	CD34	c-met	947	4233	Gene	Gene	Mobilization|nmod|START_ENTITY Mobilization|amod|END_ENTITY	Mobilization of CD34 -LRB- + -RRB- , CD117 -LRB- + -RRB- , CXCR4 -LRB- + -RRB- , c-met -LRB- + -RRB- stem cells is correlated with left_ventricular_ejection_fraction and plasma NT-proBNP levels in patients with acute_myocardial_infarction .
14562121	0	CD34	63,67	fibroblast_growth_factor_receptor_3	24,59	CD34	fibroblast growth factor receptor 3	947	2261	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Increased expression of fibroblast_growth_factor_receptor_3 in CD34 + BCR-ABL + cells from patients with chronic_myeloid_leukemia .
10089903	0	CD34	74,78	granulocyte-macrophage_colony-stimulating_factor	115,163	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	progenitors|compound|START_ENTITY progenitors|dep|role role|nmod|END_ENTITY	Expansion of granulocyte_colony-stimulating_factor / chemotherapy-mobilized CD34 + hematopoietic progenitors : role of granulocyte-macrophage_colony-stimulating_factor / erythropoietin hybrid protein -LRB- MEN11303 -RRB- and interleukin-15 .
10942362	0	CD34	39,43	granulocyte-macrophage_colony-stimulating_factor	106,154	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	hematopoietic|compound|START_ENTITY expression|nmod|hematopoietic progenitors|nsubj|expression progenitors|nmod|blood blood|acl|induced induced|nmod|END_ENTITY	CXC_chemokine_receptor_3 expression on CD34 -LRB- + -RRB- hematopoietic progenitors from human cord blood induced by granulocyte-macrophage_colony-stimulating_factor : chemotaxis and adhesion induced by its ligands , interferon_gamma-inducible_protein_10 and monokine_induced_by_interferon_gamma .
12542531	0	CD34	121,125	granulocyte-macrophage_colony-stimulating_factor	216,264	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	differentiation|nmod|START_ENTITY +|nsubj|differentiation +|nmod|END_ENTITY	Macrophage colony-stimulating factor in cooperation with transforming_growth_factor-beta1 induces the differentiation of CD34 + hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage_colony-stimulating_factor .
15447861	0	CD34	137,141	granulocyte-macrophage_colony-stimulating_factor	62,110	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	-RSB-|compound|START_ENTITY mobilizing|dobj|-RSB- combined|advcl|mobilizing combined|nmod|END_ENTITY	-LSB- Low-dose granulocyte_colony-stimulating_factor combined with granulocyte-macrophage_colony-stimulating_factor for mobilizing peripheral CD34 + hematopoietic progenitor cells -RSB- .
20860426	0	CD34	44,48	granulocyte-macrophage_colony-stimulating_factor	59,107	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Short-term exposure of umbilical cord blood CD34 + cells to granulocyte-macrophage_colony-stimulating_factor early in culture improves ex vivo expansion of neutrophils .
2478216	0	CD34	15,19	granulocyte-macrophage_colony-stimulating_factor	163,211	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	cells|nummod|START_ENTITY Circulation|nmod|cells Circulation|dep|enhancement enhancement|nmod|END_ENTITY	Circulation of CD34 + hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide-treated patients : enhancement by intravenous recombinant human granulocyte-macrophage_colony-stimulating_factor .
7519073	0	CD34	91,95	granulocyte-macrophage_colony-stimulating_factor	30,78	CD34	granulocyte-macrophage colony-stimulating factor	713858(Tax:9544)	574371(Tax:9544)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Distribution of receptors for granulocyte-macrophage_colony-stimulating_factor on immature CD34 + bone marrow cells , differentiating monomyeloid progenitors , and mature blood cell subsets .
8543766	0	CD34	112,116	granulocyte-macrophage_colony-stimulating_factor	27,75	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	cells|compound|START_ENTITY subunits|nmod|cells subunits|nsubj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Differential expression of granulocyte-macrophage_colony-stimulating_factor and IL-3 receptor subunits on human CD34 + cells and leukemic cell lines .
9815891	0	CD34	84,88	granulocyte-macrophage_colony-stimulating_factor	158,206	CD34	granulocyte-macrophage colony-stimulating factor	947	1437	Gene	Gene	cells|amod|START_ENTITY presence|nmod|cells presence|acl:relcl|suppress suppress|nmod|cancers cancers|acl:relcl|secrete secrete|dobj|END_ENTITY	Mechanisms of immune suppression in patients with head_and_neck_cancer : presence of CD34 -LRB- + -RRB- cells which suppress immune functions within cancers that secrete granulocyte-macrophage_colony-stimulating_factor .
10089903	0	CD34	74,78	granulocyte_colony-stimulating_factor	13,50	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	progenitors|compound|START_ENTITY Expansion|dep|progenitors Expansion|nmod|END_ENTITY	Expansion of granulocyte_colony-stimulating_factor / chemotherapy-mobilized CD34 + hematopoietic progenitors : role of granulocyte-macrophage_colony-stimulating_factor / erythropoietin hybrid protein -LRB- MEN11303 -RRB- and interleukin-15 .
14726397	0	CD34	157,161	granulocyte_colony-stimulating_factor	70,107	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|nummod|START_ENTITY mobilization|nmod|cells END_ENTITY|nmod|mobilization	Use of recombinant human growth hormone -LRB- rhGH -RRB- plus recombinant human granulocyte_colony-stimulating_factor -LRB- rhG-CSF -RRB- for the mobilization and collection of CD34 + cells in poor mobilizers .
1524953	0	CD34	12,16	granulocyte_colony-stimulating_factor	124,161	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	+|compound|START_ENTITY progenitors|nummod|+ Circulating|dobj|progenitors stem|csubj|Circulating stem|dobj|cells cells|dep|enhancement enhancement|nmod|END_ENTITY	Circulating CD34 + hematopoietic progenitors in the harvesting peripheral blood stem cells ; enhancement by recombinant human granulocyte_colony-stimulating_factor .
15257951	0	CD34	87,91	granulocyte_colony-stimulating_factor	10,47	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	CD33|compound|START_ENTITY proportion|nmod|CD33 mobilizes|dobj|proportion mobilizes|nsubj|END_ENTITY	High-dose granulocyte_colony-stimulating_factor mobilizes a higher proportion of early CD34 -LRB- + -RRB- CD33 -LRB- - -RRB- hemopoietic progenitors in children receiving treatment for solid tumors .
15447861	0	CD34	137,141	granulocyte_colony-stimulating_factor	10,47	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	-RSB-|compound|START_ENTITY mobilizing|dobj|-RSB- combined|advcl|mobilizing combined|nsubj|END_ENTITY	-LSB- Low-dose granulocyte_colony-stimulating_factor combined with granulocyte-macrophage_colony-stimulating_factor for mobilizing peripheral CD34 + hematopoietic progenitor cells -RSB- .
15590408	0	CD34	6,10	granulocyte_colony-stimulating_factor	137,174	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	predicts|nsubj|START_ENTITY predicts|nmod|administration administration|nmod|END_ENTITY	Basal CD34 -LRB- + -RRB- cell count predicts peripheral blood progenitor cell mobilization and collection in healthy donors after administration of granulocyte_colony-stimulating_factor .
16532489	0	CD34	51,55	granulocyte_colony-stimulating_factor	108,145	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	mobilization|nmod|START_ENTITY affect|dobj|mobilization factors|acl:relcl|affect factors|dep|cells cells|nmod|donors donors|acl|treated treated|nmod|END_ENTITY	Predictive factors that affect the mobilization of CD34 -LRB- + -RRB- cells in healthy donors treated with recombinant granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
16556705	0	CD34	51,55	granulocyte_colony-stimulating_factor	118,155	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	populations|compound|START_ENTITY application|nmod|populations mobilized|nsubj|application mobilized|nmod|END_ENTITY	Characterization and clinical application of human CD34 + stem/progenitor cell populations mobilized into the blood by granulocyte_colony-stimulating_factor .
17313558	0	CD34	0,4	granulocyte_colony-stimulating_factor	36,73	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	+|nsubj|START_ENTITY +|dobj|administration administration|nmod|END_ENTITY	CD34 + dose-driven administration of granulocyte_colony-stimulating_factor after high-dose chemotherapy in lymphoma patients .
18268278	0	CD34	58,62	granulocyte_colony-stimulating_factor	10,47	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	START_ENTITY|nsubj|mobilizes mobilizes|amod|END_ENTITY	Pegylated granulocyte_colony-stimulating_factor mobilizes CD34 + cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte_colony-stimulating_factor .
18484240	0	CD34	94,98	granulocyte_colony-stimulating_factor	113,150	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34 -LRB- + -RRB- cells with granulocyte_colony-stimulating_factor and tumor_necrosis_factor-alpha .
19112912	0	CD34	1,5	granulocyte_colony-stimulating_factor	52,89	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	-LSB- CD34 cells and T cell subsets in recombinant human granulocyte_colony-stimulating_factor primed bone marrow grafts from donors with different characteristics -RSB- .
20633298	0	CD34	6,10	granulocyte_colony-stimulating_factor	31,68	CD34	granulocyte colony-stimulating factor	12490(Tax:10090)	12985(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY mobilized|nsubj|cells mobilized|nmod|liver_damage liver_damage|amod|END_ENTITY	Human CD34 + cells mobilized by granulocyte_colony-stimulating_factor ameliorate radiation-induced liver_damage in mice .
20851866	0	CD34	60,64	granulocyte_colony-stimulating_factor	112,149	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	collection|compound|START_ENTITY polymorphisms|nmod|collection Impact|nmod|polymorphisms yield|nsubj|Impact yield|nmod|administration administration|nmod|END_ENTITY	Impact of constitutional polymorphisms in VCAM1 and CD44 on CD34 + cell collection yield after administration of granulocyte_colony-stimulating_factor to healthy donors .
22683613	0	CD34	132,136	granulocyte_colony-stimulating_factor	16,53	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	hematopoietic|compound|START_ENTITY mobilization|nmod|hematopoietic granulocyte_colony-stimulating_factor|nmod|mobilization END_ENTITY|nmod|granulocyte_colony-stimulating_factor	Plerixafor plus granulocyte_colony-stimulating_factor versus placebo plus granulocyte_colony-stimulating_factor for mobilization of CD34 -LRB- + -RRB- hematopoietic stem cells in patients with multiple_myeloma and low peripheral blood CD34 -LRB- + -RRB- cell count : results of a subset analysis of a randomized trial .
22683613	0	CD34	132,136	granulocyte_colony-stimulating_factor	74,111	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	hematopoietic|compound|START_ENTITY mobilization|nmod|hematopoietic END_ENTITY|nmod|mobilization	Plerixafor plus granulocyte_colony-stimulating_factor versus placebo plus granulocyte_colony-stimulating_factor for mobilization of CD34 -LRB- + -RRB- hematopoietic stem cells in patients with multiple_myeloma and low peripheral blood CD34 -LRB- + -RRB- cell count : results of a subset analysis of a randomized trial .
7522643	0	CD34	20,24	granulocyte_colony-stimulating_factor	100,137	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	Characterization|nmod|START_ENTITY +|nsubj|Characterization +|nmod|adults adults|acl|mobilized mobilized|nmod|END_ENTITY	Characterization of CD34 + peripheral blood cells from healthy adults mobilized by recombinant human granulocyte_colony-stimulating_factor .
7542113	0	CD34	29,33	granulocyte_colony-stimulating_factor	120,157	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	Characterization|nmod|START_ENTITY +|nsubj|Characterization +|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	Characterization of enriched CD34 + cells from healthy volunteers and those from patients treated with chemotherapy plus granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
8616068	0	CD34	63,67	granulocyte_colony-stimulating_factor	88,125	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Generation|nmod|cells mobilized|nsubj|Generation mobilized|nmod|END_ENTITY	Generation of human natural killer cells from peripheral blood CD34 + cells mobilized by granulocyte_colony-stimulating_factor .
9028941	0	CD34	18,22	granulocyte_colony-stimulating_factor	101,138	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ status|nmod|cells mobilized|nsubj|status mobilized|nmod|END_ENTITY	Cycling status of CD34 + cells mobilized into peripheral blood of healthy donors by recombinant human granulocyte_colony-stimulating_factor .
9257810	0	CD34	51,55	granulocyte_colony-stimulating_factor	77,114	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|nummod|START_ENTITY cells|acl|purified purified|nmod|END_ENTITY	Transduction of retrovirus-mediated NeoR gene into CD34 + cells purified from granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized infant and cord blood .
9535034	0	CD34	153,157	granulocyte_colony-stimulating_factor	16,53	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	content|compound|START_ENTITY transplantation|nmod|content modified|dobj|transplantation modified|nsubj|END_ENTITY	T cell-depleted granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- modified allogenic bone marrow transplantation for hematological_malignancy improves graft CD34 + cell content but is associated with delayed pancytopenia .
9603397	0	CD34	29,33	granulocyte_colony-stimulating_factor	56,93	CD34	granulocyte colony-stimulating factor	947	1440	Gene	Gene	cells|compound|START_ENTITY Analysis|nmod|cells mobilized|nsubj|Analysis mobilized|nmod|END_ENTITY	Analysis of peripheral blood CD34 + cells mobilized with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- using a long-term culture system .
11579116	0	CD34	44,48	guanylyl_cyclase_C	22,40	CD34	guanylyl cyclase C	947	2984	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Ectopic expression of guanylyl_cyclase_C in CD34 + progenitor cells in peripheral blood .
10800160	0	CD34	76,80	hepatocyte_growth_factor	8,32	CD34	hepatocyte growth factor	947	3082	Gene	Gene	cells|compound|START_ENTITY Role|nmod|cells Role|nmod|END_ENTITY	Role of hepatocyte_growth_factor in the development of dendritic cells from CD34 + bone marrow cells .
8888500	0	CD34	68,72	hepatocyte_growth_factor	23,47	CD34	hepatocyte growth factor	947	3082	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Synergistic effects of hepatocyte_growth_factor on human cord blood CD34 + progenitor cells are the result of c-met receptor expression .
19074828	0	CD34	59,63	hsa-miR-10a	19,30	CD34	hsa-miR-10a	947	406902	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Down-regulation of hsa-miR-10a in chronic_myeloid_leukemia CD34 + cells increases USF2-mediated cell growth .
11756175	0	CD34	73,77	interferon-gamma	146,162	CD34	interferon-gamma	947	3458	Gene	Gene	TF-1|compound|START_ENTITY survival|nmod|TF-1 cells|compound|survival induces|dobj|cells induces|nmod|secretion secretion|nmod|END_ENTITY	Human_T-cell_leukemia_virus_type_2 induces survival and proliferation of CD34 -LRB- + -RRB- TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte_macrophage-colony-stimulating_factor .
14745429	0	CD34	72,76	interferon-gamma	20,36	CD34	interferon-gamma	947	3458	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	In vitro effects of interferon-gamma and tumor_necrosis_factor-alpha on CD34 + bone marrow progenitor cells from aplastic_anemia patients and normal donors .
9163602	0	CD34	123,127	interferon-gamma	52,68	CD34	interferon-gamma	947	3458	Gene	Gene	cells|compound|START_ENTITY Expression|nmod|cells Expression|nmod|END_ENTITY	Expression and modulation of cellular receptors for interferon-gamma , tumour necrosis factor , and Fas on human bone marrow CD34 + cells .
16886599	0	CD34	30,34	mTOR	22,26	CD34	mTOR	12490(Tax:10090)	21977(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Activation of Akt and mTOR in CD34 + / K15 + keratinocyte stem cells and skin_tumors during multi-stage mouse skin_carcinogenesis .
10382942	0	CD34	120,124	macrophage_colony-stimulating_factor	8,44	CD34	macrophage colony-stimulating factor	947	1435	Gene	Gene	cells|compound|START_ENTITY Role|nmod|cells Role|nmod|END_ENTITY	Role of macrophage_colony-stimulating_factor in the differentiation and expansion of monocytes and dendritic cells from CD34 + progenitor cells .
15034761	0	CD34	55,59	matrix_metalloproteinase-9	14,40	CD34	matrix metalloproteinase-9	947	4318	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Production of matrix_metalloproteinase-9 by cord blood CD34 + cells and its role in migration .
24690917	0	CD34	55,59	miR-125a	18,26	CD34	miR-125a	947	406910	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Overexpression of miR-125a in myelodysplastic_syndrome CD34 + cells modulates NF-kB activation and enhances erythroid differentiation arrest .
22540071	0	CD34	123,127	myeloperoxidase	48,63	CD34	myeloperoxidase	947	4353	Gene	Gene	antibodies|compound|START_ENTITY using|dobj|antibodies observed|advcl|using observed|nsubj|drug_eruption drug_eruption|nmod|presence presence|nmod|END_ENTITY	Bullous allergic drug_eruption with presence of myeloperoxidase and reorganization of the dermal vessels observed by using CD34 and collagen IV antibodies .
26960457	0	CD34	24,28	p16	19,22	CD34	p16	947	1029	Gene	Gene	Ki-67|appos|START_ENTITY Ki-67|appos|END_ENTITY	The role of Ki-67 , p16 , CD34 , Bcl-2 , cyclooxygenase-2 in the pathogenesis of proliferative_verrucous_leukoplakia .
12456965	0	CD34	79,83	p21	40,43	CD34	p21	947	1026	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- early progenitors cultured over human MSCs as a feeder layer .
18818438	0	CD34	52,56	p21	132,135	CD34	p21	947	1026	Gene	Gene	cells|nummod|START_ENTITY infection|nmod|cells induces|nsubj|infection induces|nmod|modulation modulation|nmod|cip1/waf1 cip1/waf1|amod|END_ENTITY	Human_T-cell_lymphotropic_virus_type_1 infection of CD34 + hematopoietic progenitor cells induces cell cycle arrest by modulation of p21 -LRB- cip1/waf1 -RRB- and survivin .
23219618	0	CD34	0,4	p21	74,77	CD34	p21	947	644914	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|patients patients|nmod|END_ENTITY	CD34 + cells from patients with myelodysplastic_syndrome present different p21 dependent premature senescence .
16519794	0	CD34	64,68	p50	56,59	CD34	p50	947	4790	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|appos|END_ENTITY	Enhanced expression of mRNA for nuclear factor kappaB1 -LRB- p50 -RRB- in CD34 + cells of the bone marrow in rheumatoid_arthritis .
11781656	0	CD34	103,107	p53	30,33	CD34	p53	947	7157	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells affect|dobj|activity affect|nsubj|vivo vivo|acl|purging purging|nmod|therapy therapy|compound|END_ENTITY	Ex vivo purging by adenoviral p53 gene therapy does not affect NOD-SCID repopulating activity of human CD34 + cells .
12763212	0	CD34	52,56	p53	34,37	CD34	p53	947	7157	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
15319293	0	CD34	69,73	p53	154,157	CD34	p53	947	22060(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY silencing|nmod|cells gene|acl|silencing effect|nmod|gene Monitoring|dobj|effect Monitoring|dep|mice mice|nmod|END_ENTITY	Monitoring the effect of gene silencing by RNA interference in human CD34 + cells injected into newborn RAG2 - / - gammac - / - mice : functional inactivation of p53 in developing T cells .
19922768	0	CD34	39,43	p53	79,82	CD34	p53	12490(Tax:10090)	22060(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY generation|nmod|cells +|nsubj|generation +|nmod|inhibition inhibition|nmod|END_ENTITY	Effective generation of iPS cells from CD34 + cord blood cells by inhibition of p53 .
21894749	0	CD34	57,61	p53	30,33	CD34	p53	947	7157	Gene	Gene	cells|nummod|START_ENTITY study|nmod|cells study|nmod|END_ENTITY	-LSB- Dynamic study of Bcl-2 , Bax , p53 , and ACE expression in CD34 + cells of peripheral blood and bone marrow in acute_leukemia patients in the course of induction chemotherapy -RSB- .
24492332	0	CD34	24,28	p53	30,33	CD34	p53	947	7157	Gene	Gene	CD117|dep|START_ENTITY CD117|dep|END_ENTITY	Utility of Ki-67 , CD10 , CD34 , p53 , CD117 , and mast cell content in the differential diagnosis of cellular fibroadenomas and in the classification of phyllodes tumors of the breast .
26431162	0	CD34	112,116	p53	23,26	CD34	p53	947	7157	Gene	Gene	proliferating|compound|START_ENTITY inhibition|nmod|proliferating inhibition|nsubj|effects effects|nmod|activation activation|compound|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
7786800	0	CD34	62,66	p53	105,108	CD34	p53	947	7157	Gene	Gene	cells|nummod|START_ENTITY treating|dobj|cells treating|nmod|END_ENTITY	Modulation of cell kinetics and cell cycle status by treating CD34 + chronic_myeloid_leukaemia cells with p53 antisense phosphorothioate oligonucleotides .
18436865	0	CD34	80,84	signal_transducer_and_activator_of_transcription_5	18,68	CD34	signal transducer and activator of transcription 5	947	6776	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|nmod|cells	Downregulation of signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- in CD34 + cells promotes megakaryocytic development , whereas activation of STAT5 drives erythropoiesis .
10720698	0	CD34	85,89	stem_cell_factor	104,120	CD34	stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Effective ex vivo generation of megakaryocytic cells from mobilized peripheral blood CD34 -LRB- + -RRB- cells with stem_cell_factor and promegapoietin .
10729991	0	CD34	67,71	stem_cell_factor	103,119	CD34	stem cell factor	12490(Tax:10090)	17311(Tax:10090)	Gene	Gene	C-Kit|nummod|START_ENTITY +|appos|C-Kit +|dep|cells cells|dep|study study|nmod|END_ENTITY	Thrombopoietin stimulates murine lineage negative , Sca-1 + , C-Kit + , CD34 - cells : comparative study with stem_cell_factor or interleukin-3 .
11796924	0	CD34	138,142	stem_cell_factor	76,92	CD34	stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells increase|nmod|expansion increase|nmod|END_ENTITY	Decrease in apoptosis and increase in polyploidization of megakaryocytes by stem_cell_factor during ex vivo expansion of human cord blood CD34 + cells using thrombopoietin .
12047434	0	CD34	75,79	stem_cell_factor	117,133	CD34	stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY cells|dep|cultured cultured|nmod|presence presence|nmod|END_ENTITY	Characterization of ` adult-type ' mast cells derived from human bone marrow CD34 -LRB- + -RRB- cells cultured in the presence of stem_cell_factor and interleukin-6 .
12050184	0	CD34	12,16	stem_cell_factor	51,67	CD34	stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY cells|acl|stimulated stimulated|nmod|END_ENTITY	Bone marrow CD34 + progenitor cells stimulated with stem_cell_factor and GM-CSF have the capacity to activate IgD - B cells through direct cellular interaction .
12804177	0	CD34	71,75	stem_cell_factor	150,166	CD34	stem cell factor	947	4254	Gene	Gene	+|compound|START_ENTITY megakaryocytes|nmod|+ expansion|nmod|megakaryocytes expansion|dep|cells cells|nmod|presence presence|nmod|amounts amounts|nmod|END_ENTITY	Preferential ex vivo expansion of megakaryocytes from human cord blood CD34 + - enriched cells in the presence of thrombopoietin and limiting amounts of stem_cell_factor and Flt-3_ligand .
1375106	0	CD34	66,70	stem_cell_factor	126,142	CD34	stem cell factor	947	4254	Gene	Gene	culture|nmod|START_ENTITY colony-forming_cells|nmod|culture generation|nmod|colony-forming_cells +|nsubj|generation +|nmod|presence presence|nmod|END_ENTITY	Long-term generation of colony-forming_cells in liquid culture of CD34 + cord blood cells in the presence of recombinant human stem_cell_factor .
1379853	0	CD34	94,98	stem_cell_factor	34,50	CD34	stem cell factor	947	4254	Gene	Gene	types|compound|START_ENTITY expansion|nmod|types mediates|dobj|expansion mediates|nsubj|c-kit_ligand c-kit_ligand|appos|END_ENTITY	A c-kit_ligand , recombinant human stem_cell_factor , mediates reversible expansion of multiple CD34 + colony-forming cell types in blood and marrow of baboons .
1383918	0	CD34	124,128	stem_cell_factor	24,40	CD34	stem cell factor	947	4254	Gene	Gene	blood|compound|START_ENTITY myeloid|nmod|blood myeloid|nsubj|effects effects|nmod|END_ENTITY	The in vitro effects of stem_cell_factor and PIXY321 on myeloid progenitor formation -LRB- CFU-GM -RRB- from immunomagnetic separated CD34 + cord blood .
15196280	0	CD34	163,167	stem_cell_factor	208,224	CD34	stem cell factor	947	4254	Gene	Gene	progenitors|compound|START_ENTITY progenitors|dep|cultured cultured|nmod|presence presence|nmod|END_ENTITY	Functional expression of high-affinity receptor for immunoglobulin E on mast cells precedes that of tryptase during differentiation from human bone marrow-derived CD34 progenitors cultured in the presence of stem_cell_factor and interleukin-6 .
15831091	0	CD34	0,4	stem_cell_factor	24,40	CD34	stem cell factor	947	4254	Gene	Gene	cells|nummod|START_ENTITY cells|acl|cultured cultured|nmod|END_ENTITY	CD34 + cells cultured in stem_cell_factor and interleukin-2 generate CD56 + cells with antiproliferative effects on tumor cell lines .
1710148	0	CD34	155,159	stem_cell_factor	18,34	CD34	stem cell factor	947	4254	Gene	Gene	lin|compound|START_ENTITY enhances|nmod|lin enhances|nsubj|END_ENTITY	Recombinant human stem_cell_factor enhances the formation of colonies by CD34 + and CD34 + lin - cells , and the generation of colony-forming cell progeny from CD34 + lin - cells cultured with interleukin-3 , granulocyte_colony-stimulating_factor , or granulocyte-macrophage_colony-stimulating_factor .
1710148	0	CD34	73,77	stem_cell_factor	18,34	CD34	stem cell factor	947	4254	Gene	Gene	+|compound|START_ENTITY colonies|nmod|+ formation|nmod|colonies enhances|dobj|formation enhances|nsubj|END_ENTITY	Recombinant human stem_cell_factor enhances the formation of colonies by CD34 + and CD34 + lin - cells , and the generation of colony-forming cell progeny from CD34 + lin - cells cultured with interleukin-3 , granulocyte_colony-stimulating_factor , or granulocyte-macrophage_colony-stimulating_factor .
21963880	0	CD34	89,93	stem_cell_factor	31,47	CD34	stem cell factor	713858(Tax:9544)	574254(Tax:9544)	Gene	Gene	transplantation|compound|START_ENTITY improve|nmod|transplantation END_ENTITY|xcomp|improve	Keratinocyte_growth_factor and stem_cell_factor to improve thymopoiesis after autologous CD34 + cell transplantation in rhesus_macaques .
7524746	0	CD34	67,71	stem_cell_factor	106,122	CD34	stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY cultures|nmod|cells cells|nmod|cultures generation|nmod|cells stimulated|nsubj|generation stimulated|nmod|END_ENTITY	Long-term generation of human mast cells in serum-free cultures of CD34 + cord blood cells stimulated with stem_cell_factor and interleukin-3 .
7525328	0	CD34	107,111	stem_cell_factor	58,74	CD34	stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY confers|nmod|cells confers|dep|exit exit|nmod|END_ENTITY	Rapid exit from G0/G1 phases of cell cycle in response to stem_cell_factor confers on umbilical cord blood CD34 + cells an enhanced ex vivo expansion potential .
7552984	0	CD34	108,112	stem_cell_factor	47,63	CD34	stem cell factor	713858(Tax:9544)	574254(Tax:9544)	Gene	Gene	cells|compound|START_ENTITY transduction|nmod|cells END_ENTITY|nmod|transduction	Influence of interleukin-3 , interleukin-6 , and stem_cell_factor on retroviral transduction of rhesus_monkey CD34 + hematopoietic progenitor cells measured in vitro and in vivo .
7694867	0	CD34	67,71	stem_cell_factor	117,133	CD34	stem cell factor	947	4254	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ proliferation|dep|cells cells|nmod|END_ENTITY	Interleukin-11 stimulates the proliferation of human hematopoietic CD34 + and CD34 + CD33-DR - cells and synergizes with stem_cell_factor , interleukin-3 , and granulocyte-macrophage_colony-stimulating_factor .
9885212	0	CD34	88,92	stem_cell_factor	47,63	CD34	stem cell factor	947	4254	Gene	Gene	production|nmod|START_ENTITY production|nmod|combination combination|nmod|END_ENTITY	Neutrophilic cell production by combination of stem_cell_factor and thrombopoietin from CD34 -LRB- + -RRB- cord blood cells in long-term serum-deprived liquid culture .
9933129	0	CD34	98,102	stem_cell_factor	38,54	CD34	stem cell factor	947	4254	Gene	Gene	cells|compound|START_ENTITY growth|nmod|cells Role|nmod|growth Role|nmod|END_ENTITY	Role of physiologic concentrations of stem_cell_factor in leukemic type growth of myelodysplastic CD34 + cells .
9852236	0	CD34	38,42	substance_P	23,34	CD34	substance P	947	6863	Gene	Gene	proliferation|compound|START_ENTITY END_ENTITY|nmod|proliferation	Stimulatory effects of substance_P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function .
16417922	0	CD34	80,84	terminal_deoxynucleotidyl_transferase	22,59	CD34	terminal deoxynucleotidyl transferase	947	1791	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	Evaluation of CD7 and terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- expression in CD34 + myeloblasts from patients with myelodysplastic_syndrome .
11380418	0	CD34	90,94	thrombopoietin	108,122	CD34	thrombopoietin	947	7066	Gene	Gene	START_ENTITY|xcomp|using using|dobj|END_ENTITY	Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34 + cells using thrombopoietin .
11841696	0	CD34	69,73	thrombopoietin	87,101	CD34	thrombopoietin	947	7066	Gene	Gene	START_ENTITY|xcomp|using using|dobj|END_ENTITY	Megakaryothrombopoiesis during ex vivo expansion of human cord blood CD34 + cells using thrombopoietin .
15145213	0	CD34	81,85	tumor_necrosis_factor-alpha	98,125	CD34	tumor necrosis factor-alpha	947	7124	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Codevelopment of dendritic cells along with erythroid differentiation from human CD34 -LRB- + -RRB- cells by tumor_necrosis_factor-alpha .
8723796	0	CD34	74,78	tumor_necrosis_factor-alpha	135,162	CD34	tumor necrosis factor-alpha	947	7124	Gene	Gene	progenitors|compound|START_ENTITY transduction|nmod|progenitors interleukin|nmod|transduction effects|nmod|interleukin mediated|nsubj|effects mediated|nmod|induction induction|nmod|END_ENTITY	Inhibitory effects of interleukin 12 on retroviral gene transduction into CD34 cord blood myeloid progenitors mediated by induction of tumor_necrosis_factor-alpha .
1671871	0	CD35	34,38	CR1	29,32	CD35	CR1	1378	1378	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Genomic determination of the CR1 -LRB- CD35 -RRB- density polymorphism on erythrocytes using polymerase chain reaction amplification and HindIII restriction enzyme digestion .
2402120	0	CD35	19,23	CR1	14,17	CD35	CR1	1378	1378	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression of CR1 -LRB- CD35 -RRB- mRNA in podocytes from adult and fetal human kidneys .
16211218	0	CD36	44,48	CD29	14,18	CD36	CD29	948	3688	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD29 on lymphoma cells and/or CD36 on microvascular endothels correlates with high serum LDH level in diffuse large B-cell_lymphomas -LRB- DLBCLs -RRB- and is frequent in de novo CD5-positive DLBCLs .
9639415	0	CD36	6,10	CD34	0,4	CD36	CD34	948	947	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	CD34 + / CD36 - cells from myelodysplasia patients have a limited capacity to proliferate but can differentiate in response to Epo and MGF stimulation .
12055215	0	CD36	0,4	CD8	36,39	CD36	CD8	948	925	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	CD36 is differentially expressed by CD8 + splenic dendritic cells but is not required for cross-presentation in vivo .
11238109	0	CD36	0,4	CD9	21,24	CD36	CD9	948	928	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	CD36 associates with CD9 and integrins on human blood platelets .
22216174	0	CD36	31,35	CD9	0,3	CD36	CD9	12491(Tax:10090)	12527(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	CD9 tetraspanin interacts with CD36 on the surface of macrophages : a possible regulatory influence on uptake of oxidized low density lipoprotein .
7509795	1	CD36	138,142	CLA-1	163,168	CD36	CLA-1	948	949	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	Conservation of exon organization and pre-mRNA splicing patterns with a CD36 gene family member , CLA-1 .
16985264	0	CD36	23,27	Endothelin-1	0,12	CD36	Endothelin-1	948	1906	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Endothelin-1 decreases CD36 protein expression in vascular smooth muscle cells .
17458857	0	CD36	28,32	IL-13	0,5	CD36	IL-13	948	3596	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-13 induces expression of CD36 in human monocytes through PPARgamma activation .
18441389	0	CD36	77,81	Insulin	0,7	CD36	Insulin	948	3630	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Insulin acutely upregulates protein expression of the fatty_acid transporter CD36 in human skeletal muscle in vivo .
18302760	0	CD36	56,60	Nrf-2	40,45	CD36	Nrf-2	12491(Tax:10090)	18024(Tax:10090)	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|amod|dependent dependent|amod|END_ENTITY	Rosiglitazone but not losartan prevents Nrf-2 dependent CD36 gene expression up-regulation in an in vivo atherosclerosis model .
11937630	0	CD36	16,20	Oct-2	0,5	CD36	Oct-2	12491(Tax:10090)	18987(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oct-2 regulates CD36 gene expression via a consensus octamer , which excludes the co-activator OBF-1 .
12356675	0	CD36	27,31	Oct-2	72,77	CD36	Oct-2	12491(Tax:10090)	18987(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulation|nmod|expression regulation|dep|dependence dependence|compound|END_ENTITY	Differential regulation of CD36 expression in antigen-presenting cells : Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages .
7543064	0	CD36	18,22	Oct-2	88,93	CD36	Oct-2	12491(Tax:10090)	18987(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|amod|dependent dependent|nmod|END_ENTITY	Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2 .
1699598	0	CD36	110,114	PAS_IV	0,6	CD36	PAS IV	948	948	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	PAS_IV , an integral membrane protein of mammary epithelial cells , is related to platelet and endothelial cell CD36 -LRB- GP_IV -RRB- .
26494228	0	CD36	14,18	PCSK9	0,5	CD36	PCSK9	12491(Tax:10090)	100102(Tax:10090)	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty_Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver .
19088437	0	CD36	40,44	PPAR-gamma	8,18	CD36	PPAR-gamma	948	5468	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line .
17084382	0	CD36	53,57	PPARalpha	78,87	CD36	PPARalpha	948	5465	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Cholesteryl_ester hydroperoxides increase macrophage CD36 gene expression via PPARalpha .
11972632	0	CD36	86,90	PPARgamma	50,59	CD36	PPARgamma	948	5468	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Peroxisome-proliferator-activated-receptor_gamma -LRB- PPARgamma -RRB- independent induction of CD36 in THP-1 monocytes by retinoic_acid .
26504087	0	CD36	60,64	PPARy	51,56	CD36	PPARy	948	5468	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	ROS mediates p300-dependent STAT1 interaction with PPARy in CD36 expression and foam cell formation .
12238639	0	CD36	37,41	SR-A	70,74	CD36	SR-A	948	4481	Gene	Gene	expression|nmod|START_ENTITY increased|dobj|expression increased|nmod|END_ENTITY	Synergically increased expression of CD36 , CLA-1 and CD68 , but not of SR-A and LOX-1 , with the progression to foam cells from macrophages .
11561009	0	CD36	36,40	SR-BI	51,56	CD36	SR-BI	948	949	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of the lipid receptors CD36 and CLA-1 / SR-BI in the human gastrointestinal tract : towards the identification of receptors mediating the intestinal absorption of dietary lipids .
25389062	0	CD36	74,78	SR-BI	115,120	CD36	SR-BI	948	949	Gene	Gene	Expression|nmod|START_ENTITY Foam|dep|Expression Foam|dep|Expression Expression|nmod|END_ENTITY	Icariin Inhibits Foam Cell Formation By Down-Regulating the Expression of CD36 and Up-Regulating the Expression of SR-BI .
25721714	0	CD36	26,30	TCF4	46,50	CD36	TCF4	948	6925	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-y in Macrophages .
25010893	0	CD36	123,127	THP-1	131,136	CD36	THP-1	948	2736	Gene	Gene	START_ENTITY|nmod|macrophages macrophages|compound|END_ENTITY	Kimchi methanol extract and the kimchi active compound , 3 ' - -LRB- 4 ' - hydroxyl-3 ' ,5 ' - dimethoxyphenyl -RRB- propionic_acid , downregulate CD36 in THP-1 macrophages stimulated by oxLDL .
1383273	0	CD36	31,35	Thrombospondin	0,14	CD36	Thrombospondin	948	7057	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis .
1384794	0	CD36	37,41	Thrombospondin	0,14	CD36	Thrombospondin	948	7057	Gene	Gene	reticulocytes|compound|START_ENTITY adherence|nmod|reticulocytes mediates|dobj|adherence mediates|nsubj|END_ENTITY	Thrombospondin mediates adherence of CD36 + sickle reticulocytes to endothelial cells .
24148348	0	CD36	17,21	Thrombospondin-1	0,16	CD36	Thrombospondin-1	12491(Tax:10090)	21825(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|parataxis|contributes	Thrombospondin-1 / CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic_hedgehog pathway suppression .
17335569	0	CD36	67,71	Tumor_necrosis_factor_alpha	0,27	CD36	Tumor necrosis factor alpha	948	7124	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha and adalimumab differentially regulate CD36 expression in human monocytes .
19928818	0	CD36	156,160	VEGF	36,40	CD36	VEGF	12491(Tax:10090)	22339(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY induction|dep|association induction|compound|END_ENTITY	Dietary compound quercitrin dampens VEGF induction and PPARgamma activation in oxidized LDL-exposed murine macrophages : association with scavenger receptor CD36 .
23896411	0	CD36	46,50	VEGF	27,31	CD36	VEGF	12491(Tax:10090)	22339(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells .
25721714	0	CD36	26,30	Wnt1	0,4	CD36	Wnt1	948	7471	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-y in Macrophages .
18827892	0	CD36	0,4	adipophilin	38,49	CD36	adipophilin	948	123	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	CD36 is significantly correlated with adipophilin in human carotid lesions and inversely correlated with plasma ApoAI .
24366867	0	CD36	125,129	cluster_of_differentiation_36	94,123	CD36	cluster of differentiation 36	12491(Tax:10090)	12491(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Endoplasmic reticulum stress promotes macrophage-derived foam cell formation by up-regulating cluster_of_differentiation_36 -LRB- CD36 -RRB- expression .
16959872	0	CD36	65,69	growth_hormone-releasing_peptide	2,34	CD36	growth hormone-releasing peptide	12491(Tax:10090)	58991(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY END_ENTITY|acl:relcl|binds	A growth_hormone-releasing_peptide that binds scavenger receptor CD36 and ghrelin_receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome_proliferator-activated_receptor_gamma-dependent pathway .
17138655	0	CD36	129,133	growth_hormone-releasing_peptide	2,34	CD36	growth hormone-releasing peptide	12491(Tax:10090)	58991(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	A growth_hormone-releasing_peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes .
11247544	0	CD36	0,4	insulin	6,13	CD36	insulin	948	3630	Gene	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	CD36 , insulin resistance , and coronary_heart_disease .
1379600	1	CD36	91,95	thrombospondin	101,115	CD36	thrombospondin	948	7057	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|receptor receptor|compound|END_ENTITY	Role of CD36 as a thrombospondin receptor .
7688364	0	CD36	118,122	thrombospondin	27,41	CD36	thrombospondin	948	7057	Gene	Gene	receptor|appos|START_ENTITY site|nmod|receptor SVTCG|nmod|site SVTCG|nmod|END_ENTITY	Identification of SVTCG in thrombospondin as the conformation-dependent , high affinity binding site for its receptor , CD36 .
9245797	0	CD36	0,4	thrombospondin-1	49,65	CD36	thrombospondin-1	948	7057	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells .
9747513	0	CD36	0,4	thrombospondin-1	33,49	CD36	thrombospondin-1	12491(Tax:10090)	21825(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|binding binding|nmod|END_ENTITY	CD36 mediates binding of soluble thrombospondin-1 but not cell adhesion and haptotaxis on immobilized thrombospondin-1 .
9285527	0	CD36	44,48	tumor_necrosis_factor-alpha	134,161	CD36	tumor necrosis factor-alpha	948	7124	Gene	Gene	domain|nmod|START_ENTITY required|nsubjpass|domain required|nmod|END_ENTITY	The carboxyl-terminal cytoplasmic domain of CD36 is required for oxidized low-density lipoprotein modulation of NF-kappaB activity by tumor_necrosis_factor-alpha .
15576377	0	CD36_and_LIMPII_analogous-1	34,61	CLA-1	27,32	CD36 and LIMPII analogous-1	CLA-1	949;948	949	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Serum amyloid A binding to CLA-1 -LRB- CD36_and_LIMPII_analogous-1 -RRB- mediates serum_amyloid_A_protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases .
23686525	0	CD38	8,12	Aurora_kinase_A	68,83	CD38	Aurora kinase A	952	6790	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	CD34 ___ / CD38 acute_myelogenous_leukemia cells aberrantly express Aurora_kinase_A .
18415658	0	CD38	36,40	CD123	42,47	CD38	CD123	952	3563	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	HERG K + channel expression in CD34 + / CD38 - / CD123 -LRB- high -RRB- cells and primary leukemia cells and analysis of its regulation in leukemia cells .
24846193	0	CD38	15,19	CD123	21,26	CD38	CD123	952	3563	Gene	Gene	START_ENTITY|dep|cells cells|nummod|END_ENTITY	Increased CD34 + CD38 - CD123 + cells in myelodysplastic_syndrome displaying malignant features similar to those in AML .
15359642	0	CD38	31,35	CD19	38,42	CD38	CD19	952	930	Gene	Gene	START_ENTITY|parataxis|+ +|compound|END_ENTITY	In multiple_myeloma clonotypic CD38 - / CD19 + / CD27 + memory B cells recirculate through bone marrow , peripheral blood and lymph nodes .
15573184	0	CD38	79,83	CD19	61,65	CD38	CD19	952	930	Gene	Gene	CD56|nummod|START_ENTITY CD56|nummod|END_ENTITY	Flow cytometric evaluation of bone marrow plasma cells using CD19 , CD45 , CD56 , CD38 , and CD138 and correlation with bone_marrow_infiltration ratio in multiple myeloma patients .
18160830	0	CD38	46,50	CD19	59,63	CD38	CD19	952	930	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|appos|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18418410	0	CD38	5,9	CD19	10,14	CD38	CD19	952	930	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD34 + CD38 + CD19 + as well as CD34 + CD38-CD19 + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL .
20079667	0	CD38	15,19	CD19	0,4	CD38	CD19	952	930	Gene	Gene	START_ENTITY|nsubj|CD24 CD24|compound|END_ENTITY	CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic_Lupus_Erythematosus patients .
23755918	0	CD38	68,72	CD19	51,55	CD38	CD19	952	930	Gene	Gene	B|compound|START_ENTITY CD24|dep|B CD24|compound|END_ENTITY	An age-related numerical and functional deficit in CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- B cells is associated with an increase in systemic autoimmunity .
24935080	0	CD38	38,42	CD19	21,25	CD38	CD19	952	930	Gene	Gene	cells|amod|START_ENTITY function|nmod|cells function|nmod|CD24 CD24|compound|END_ENTITY	Impaired function of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B cells in patients with pemphigus .
26557732	0	CD38	141,145	CD19	124,128	CD38	CD19	952	930	Gene	Gene	START_ENTITY|amod|lymphocytes lymphocytes|nmod|activation activation|nmod|END_ENTITY	Effect of Stress-Free Therapy on immune system : Induction of Interleukin_10 expression in lymphocytes through activation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B Cells .
26758063	0	CD38	31,35	CD19	16,20	CD38	CD19	952	930	Gene	Gene	START_ENTITY|compound|CD24 CD24|compound|END_ENTITY	Upregulation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B cells is associated with a reduced risk of acute_lung_injury in elderly pneumonia patients .
26852663	0	CD38	27,31	CD19	20,24	CD38	CD19	952	930	Gene	Gene	CD24|compound|START_ENTITY +|dep|CD24 +|compound|END_ENTITY	Regulatory B cells -LRB- CD19 -LRB- + -RRB- CD38 -LRB- hi -RRB- CD24 -LRB- hi -RRB- -RRB- in alloimmunized and non-alloimmunized children with b-thalassemia major .
7529064	0	CD38	107,111	CD19	67,71	CD38	CD19	952	930	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|nummod|END_ENTITY	In multiple_myeloma , clonotypic B lymphocytes are detectable among CD19 + peripheral blood cells expressing CD38 , CD56 , and monotypic Ig light chain .
9200454	0	CD38	0,4	CD19	103,107	CD38	CD19	952	930	Gene	Gene	ligation|nummod|START_ENTITY triggers|nsubj|ligation triggers|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
9200454	0	CD38	0,4	CD19	79,83	CD38	CD19	952	930	Gene	Gene	ligation|nummod|START_ENTITY triggers|nsubj|ligation triggers|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and phosphatidylinositol_3-kinase .
22997842	0	CD38	16,20	CD24	51,55	CD38	CD24	952	100133941	Gene	Gene	biomarker|compound|START_ENTITY role|nmod|biomarker role|nmod|END_ENTITY	Pivotal role of CD38 biomarker in combination with CD24 , EpCAM , and ALDH for identification of H460 derived lung_cancer stem cells .
23755918	0	CD38	68,72	CD24	59,63	CD38	CD24	952	100133941	Gene	Gene	B|compound|START_ENTITY END_ENTITY|dep|B	An age-related numerical and functional deficit in CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- B cells is associated with an increase in systemic autoimmunity .
24094028	0	CD38	6,10	CD24	0,4	CD38	CD24	952	100133941	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	CD24 + / CD38 - as new prognostic marker for non-small cell lung_cancer .
24935080	0	CD38	38,42	CD24	29,33	CD38	CD24	952	100133941	Gene	Gene	cells|amod|START_ENTITY function|nmod|cells function|nmod|END_ENTITY	Impaired function of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B cells in patients with pemphigus .
12673718	0	CD38	60,64	CD31	44,48	CD38	CD31	952	5175	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|relevance relevance|nmod|expression expression|nmod|END_ENTITY	Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B-cell_chronic_lymphocytic_leukemia .
26407101	0	CD38	8,12	CD31	76,80	CD38	CD31	952	5175	Gene	Gene	Enhances|nsubj|START_ENTITY Enhances|nmod|END_ENTITY	Seminal CD38 Enhances Human Sperm Capacitation through Its Interaction with CD31 .
9551996	0	CD38	6,10	CD31	58,62	CD38	CD31	952	5175	Gene	Gene	counter-receptor|nsubj|START_ENTITY counter-receptor|nmod|END_ENTITY	Human CD38 -LRB- ADP-ribosyl cyclase -RRB- is a counter-receptor of CD31 , an Ig superfamily member .
21993666	0	CD38	8,12	CD33	73,77	CD38	CD33	952	945	Gene	Gene	stem|nsubj|START_ENTITY stem|dobj|cells cells|nmod|Siglec-3 Siglec-3|appos|END_ENTITY	CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- stem cells in chronic_myeloid_leukemia express Siglec-3 -LRB- CD33 -RRB- and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin .
10419883	0	CD38	126,130	CD34	119,123	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The soluble interleukin-6 -LRB- IL-6 -RRB- receptor/IL -6 fusion protein enhances in vitro maintenance and proliferation of human CD34 -LRB- + -RRB- CD38 -LRB- - / low -RRB- cells capable of repopulating severe_combined_immunodeficiency mice .
10477721	0	CD38	67,71	CD34	60,64	CD38	CD34	952	947	Gene	Gene	START_ENTITY|nsubj|differentiation differentiation|nmod|subset subset|nmod|END_ENTITY	Rapid differentiation of a rare subset of adult human lin -LRB- - -RRB- CD34 -LRB- - -RRB- CD38 -LRB- - -RRB- cells stimulated by multiple growth factors in vitro .
10516751	0	CD38	132,136	CD34	126,130	CD38	CD34	952	947	Gene	Gene	immunophenotype|dep|START_ENTITY immunophenotype|dep|immunogenicity immunogenicity|nmod|+ +|compound|END_ENTITY	The immunophenotype of minimally differentiated acute_myeloid_leukemia -LRB- AML-M0 -RRB- : reduced immunogenicity and high frequency of CD34 + / CD38 - leukemic progenitors .
10607692	0	CD38	37,41	CD34	30,34	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Expansion of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell -LRB- SRC -RRB- frequency : dissociation of SRC phenotype and function .
11342460	0	CD38	43,47	CD34	36,40	CD38	CD34	952	947	Gene	Gene	CXCR4|compound|START_ENTITY CXCR4|amod|END_ENTITY	Rapid and efficient homing of human CD34 -LRB- + -RRB- CD38 -LRB- - / low -RRB- CXCR4 -LRB- + -RRB- stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m -LRB- null -RRB- mice .
11388746	0	CD38	104,108	CD34	14,18	CD38	CD34	952	947	Gene	Gene	using|dobj|START_ENTITY experience|acl|using Importance|dep|experience Importance|nmod|subsets subsets|nummod|END_ENTITY	Importance of CD34 + cell subsets in autologous PBSC transplantation : the mulhouse experience using CD34 + CD38 - cells as predictive tool for hematopoietic engraftment .
11588023	8	CD38	1471,1475	CD34	1463,1467	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY displayed|nsubj|cells showed|parataxis|displayed showed|nsubj|END_ENTITY	Leukemic CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- cells displayed a rapid induction of cell death in response to MG-132 , whereas normal CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- cells showed little if any effect .
11857070	0	CD38	78,82	CD34	60,64	CD38	CD34	952	947	Gene	Gene	START_ENTITY|nsubj|conversion conversion|nmod|END_ENTITY	Targeted beta-globin gene conversion in human hematopoietic CD34 -LRB- + -RRB- and Lin -LRB- - -RRB- CD38 -LRB- - -RRB- cells .
11999573	0	CD38	100,104	CD34	94,98	CD38	CD34	952	947	Gene	Gene	+|compound|START_ENTITY CD38|dep|+ CD38|compound|END_ENTITY	Induction of apoptosis by cladribine -LRB- 2-CdA -RRB- , gemcitabine and other chemotherapeutic drugs on CD34 + / CD38 + and CD34 + / CD38 - hematopoietic progenitor cells : selective effects of doxorubicin and 2-CdA with protection of immature cells .
12031654	0	CD38	65,69	CD34	58,62	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|amod|activation activation|nmod|receptor receptor|nmod|END_ENTITY	MAP kinase activation by mu opioid receptor in cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells .
12063025	0	CD38	94,98	CD34	129,133	CD38	CD34	952	947	Gene	Gene	enriched|nmod|START_ENTITY fraction|amod|enriched fraction|nmod|cells cells|compound|END_ENTITY	Myeloid-lymphoid initiating cells -LRB- ML-IC -RRB- are highly enriched in the rhodamine-c-kit -LRB- + -RRB- CD33 -LRB- - -RRB- CD38 -LRB- - -RRB- fraction of umbilical cord CD34 -LRB- + -RRB- cells .
12070035	0	CD38	52,56	CD34	45,49	CD38	CD34	952	947	Gene	Gene	Thy-1|compound|START_ENTITY Thy-1|amod|END_ENTITY	Involvement and functional impairment of the CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- Thy-1 -LRB- + -RRB- hematopoietic stem cell pool in myelodysplastic_syndromes with trisomy 8 .
12358912	0	CD38	94,98	CD34	88,92	CD38	CD34	952	947	Gene	Gene	cells|dep|START_ENTITY cells|nmod|loss loss|nmod|+ +|compound|END_ENTITY	Low blood dendritic cells in chronic_myeloid_leukaemia patients correlates with loss of CD34 + / CD38 - primitive haematopoietic progenitors .
12675725	0	CD38	5,9	CD34	85,89	CD38	CD34	952	947	Gene	Gene	marker|nsubj|START_ENTITY marker|acl|cloning cloning|dobj|potential potential|nmod|cells cells|compound|END_ENTITY	CD34 + CD38 - is a good predictive marker of cloning ability and expansion potential of CD34 + cord blood cells .
15764022	0	CD38	96,100	CD34	90,94	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Peripheral blood and BM CD34 + CD38 - cells show better resistance to cryopreservation than CD34 + CD38 + cells in autologous stem cell transplantation .
15790777	0	CD38	17,21	CD34	11,15	CD38	CD34	952	12490(Tax:10090)	Gene	Gene	potentiate|compound|START_ENTITY G1|dep|potentiate G1|dep|+ +|compound|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
15790777	0	CD38	17,21	CD34	85,89	CD38	CD34	952	12490(Tax:10090)	Gene	Gene	potentiate|compound|START_ENTITY potentiate|nmod|+ +|compound|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
15790777	0	CD38	91,95	CD34	11,15	CD38	CD34	952	12490(Tax:10090)	Gene	Gene	G1|parataxis|START_ENTITY G1|dep|+ +|compound|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
15790777	0	CD38	91,95	CD34	85,89	CD38	CD34	952	12490(Tax:10090)	Gene	Gene	G1|parataxis|START_ENTITY G1|dep|potentiate potentiate|nmod|+ +|compound|END_ENTITY	Cycling G1 CD34 + / CD38 + cells potentiate the motility and engraftment of quiescent G0 CD34 + / CD38 - / low severe combined_immunodeficiency repopulating cells .
16321850	0	CD38	55,59	CD34	49,53	CD38	CD34	952	947	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Detection of molecular targets on the surface of CD34 + / CD38 -- stem cells in various myeloid_malignancies .
17170726	0	CD38	70,74	CD34	63,67	CD38	CD34	952	947	Gene	Gene	CD7|compound|START_ENTITY CD7|amod|END_ENTITY	T - , _ B - _ and_NK-lymphoid , but not myeloid cells arise from human CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- CD7 -LRB- + -RRB- common lymphoid progenitors expressing lymphoid-specific genes .
17181570	0	CD38	48,52	CD34	42,46	CD38	CD34	952	947	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Expression of the target receptor CD33 in CD34 + / CD38 - / CD123 + AML stem cells .
18160830	0	CD38	33,37	CD34	39,43	CD38	CD34	952	947	Gene	Gene	START_ENTITY|dep|+ +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD38	33,37	CD34	84,88	CD38	CD34	952	947	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD38	46,50	CD34	52,56	CD38	CD34	952	947	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18160830	0	CD38	46,50	CD34	65,69	CD38	CD34	952	947	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- Proportions of cells expressing CD38 - / CD34 + , CD38 + / CD34 + , CD19 + / CD34 + , or CD13 ,33 + / CD34 + in the regenerating bone marrows during complete remission of acute_leukemia or after bone marrow transplantation -RSB- .
18415658	0	CD38	36,40	CD34	30,34	CD38	CD34	952	947	Gene	Gene	cells|dep|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	HERG K + channel expression in CD34 + / CD38 - / CD123 -LRB- high -RRB- cells and primary leukemia cells and analysis of its regulation in leukemia cells .
18418410	0	CD38	5,9	CD34	0,4	CD38	CD34	952	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD34 + CD38 + CD19 + as well as CD34 + CD38-CD19 + cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL .
18549635	0	CD38	120,124	CD34	113,117	CD38	CD34	952	947	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD38	120,124	CD34	89,93	CD38	CD34	952	947	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD38	96,100	CD34	113,117	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD38	96,100	CD34	89,93	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
19644143	0	CD38	8,12	CD34	27,31	CD38	CD34	952	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduced CD38 expression on CD34 + cells as a diagnostic test in myelodysplastic_syndromes .
19937912	0	CD38	147,151	CD34	135,139	CD38	CD34	952	947	Gene	Gene	cells|amod|START_ENTITY +|appos|cells +|compound|END_ENTITY	Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34 + , CD34 + CD38 - and early lymphoid CD7 + cells .
19937912	0	CD38	147,151	CD34	142,146	CD38	CD34	952	947	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Dynamic cell-cell interactions between cord blood haematopoietic progenitors and the cellular niche are essential for the expansion of CD34 + , CD34 + CD38 - and early lymphoid CD7 + cells .
20444543	0	CD38	48,52	CD34	42,46	CD38	CD34	952	947	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Enrichment of N-Cadherin and Tie2-bearing CD34 + / CD38 - / CD123 + leukemic stem cells by chemotherapy-resistance .
21128225	0	CD38	140,144	CD34	133,137	CD38	CD34	952	947	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34 + / CD38 - cells and sensitizes them to antileukemia agents .
21993666	0	CD38	8,12	CD34	0,4	CD38	CD34	952	947	Gene	Gene	stem|nsubj|START_ENTITY stem|nsubj|END_ENTITY	CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- stem cells in chronic_myeloid_leukemia express Siglec-3 -LRB- CD33 -RRB- and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin .
22262762	0	CD38	52,56	CD34	45,49	CD38	CD34	12494(Tax:10090)	12490(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|population population|nmod|END_ENTITY	A clinically relevant population of leukemic CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells in acute_myeloid_leukemia .
22306110	0	CD38	60,64	CD34	53,57	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The effects of ROS-mediating oxygen tension on human CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells induced into mature dendritic cells .
22926686	0	CD38	25,29	CD34	18,22	CD38	CD34	952	947	Gene	Gene	myeloblasts|amod|START_ENTITY myeloblasts|amod|END_ENTITY	The proportion of CD34 -LRB- + -RRB- CD38 -LRB- low or neg -RRB- myeloblasts , but not side population frequency , predicts initial response to induction therapy in patients with newly diagnosed acute_myeloid_leukemia .
23055153	0	CD38	8,12	CD34	0,4	CD38	CD34	12494(Tax:10090)	12490(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells ___|parataxis|express ___|compound|END_ENTITY	CD34 ___ / CD38 ___ acute_myelogenous_leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells .
23564444	0	CD38	56,60	CD34	48,52	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-1b inhibits self-renewal capacity of dormant CD34 / CD38 acute_myelogenous_leukemia cells in vitro and in vivo .
23686525	0	CD38	8,12	CD34	0,4	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells ___|parataxis|express ___|compound|END_ENTITY	CD34 ___ / CD38 acute_myelogenous_leukemia cells aberrantly express Aurora_kinase_A .
24023545	0	CD38	65,69	CD34	58,62	CD38	CD34	952	947	Gene	Gene	Cells|compound|START_ENTITY Expansion|dep|Cells Expansion|nmod|END_ENTITY	Wnt1 Accelerates an Ex Vivo Expansion of Human Cord Blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- Cells .
24038022	0	CD38	52,56	CD34	44,48	CD38	CD34	952	947	Gene	Gene	Loss|nmod|START_ENTITY Loss|nmod|function function|nmod|END_ENTITY	Loss of quiescence and impaired function of CD34 -LRB- + -RRB- / CD38 -LRB- low -RRB- cells one year following autologous stem cell transplantation .
24703771	0	CD38	36,40	CD34	29,33	CD38	CD34	12494(Tax:10090)	12490(Tax:10090)	Gene	Gene	leukemic|compound|START_ENTITY leukemic|compound|END_ENTITY	N-Cadherin and Tie2 positive CD34 CD38 CD123 leukemic stem cell populations can develop acute_myeloid_leukemia more effectively in NOD/SCID mice .
25102944	0	CD38	29,33	CD34	22,26	CD38	CD34	952	947	Gene	Gene	START_ENTITY|nsubj|expansion expansion|nmod|END_ENTITY	In vitro expansion of CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile_myelomonocytic_leukemia .
25588820	6	CD38	1780,1784	CD34	1771,1775	CD38	CD34	952	947	Gene	Gene	START_ENTITY|nsubj|transplanted transplanted|nmod|competition competition|nmod|/ /|compound|END_ENTITY	In vivo studies showed equivalent engraftment of transduced CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- cells when transplanted in competition with 100-fold more CD34 -LRB- + -RRB- / CD38 -LRB- + -RRB- cells .
25876768	0	CD38	160,164	CD34	150,154	CD38	CD34	952	947	Gene	Gene	blasts|amod|START_ENTITY blasts|amod|END_ENTITY	An immunophenotypic pre-treatment predictor for poor response to induction chemotherapy in older acute_myeloid_leukaemia patients : blood frequency of CD34 -LRB- + -RRB- CD38 -LRB- low -RRB- blasts .
26010294	0	CD38	122,126	CD34	128,132	CD38	CD34	952	947	Gene	Gene	START_ENTITY|parataxis|cells cells|dep|END_ENTITY	Differential antigen expression and aberrant signaling via PI3/AKT , MAP/ERK , JAK/STAT , and Wnt/b catenin pathways in Lin - / CD38 - / CD34 + cells in acute myeloid_leukemia .
26059451	0	CD38	35,39	CD34	27,31	CD38	CD34	952	947	Gene	Gene	AML|compound|START_ENTITY DNMT3A|dep|AML DNMT3A|nmod|END_ENTITY	STAT5A regulates DNMT3A in CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- AML cells .
26997358	0	CD38	79,83	CD34	130,134	CD38	CD34	952	947	Gene	Gene	START_ENTITY|dep|cells cells|acl|expanded expanded|nmod|Cells Cells|compound|END_ENTITY	Low oxygen tension favored expansion and hematopoietic reconstitution of CD34 + CD38 - cells expanded from human cord blood-derived CD34 + Cells .
7510144	0	CD38	69,73	CD34	53,57	CD38	CD34	952	947	Gene	Gene	HLA-DR|nummod|START_ENTITY +|appos|HLA-DR +|compound|END_ENTITY	Lymphoid and myeloid differentiation of single human CD34 + , HLA-DR + , CD38 - hematopoietic stem cells .
7520470	0	CD38	90,94	CD34	85,89	CD38	CD34	952	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Interferon_gamma selectively inhibits very primitive CD342 + CD38 - and not more mature CD34 + CD38 + human hematopoietic progenitor cells .
7520773	0	CD38	31,35	CD34	61,65	CD38	CD34	952	947	Gene	Gene	differences|nmod|START_ENTITY differences|dep|subfractions subfractions|nmod|cells cells|compound|END_ENTITY	Functional differences between CD38 - and DR - subfractions of CD34 + bone marrow cells .
7548327	0	CD38	41,45	CD34	73,77	CD38	CD34	952	947	Gene	Gene	subfractions|compound|START_ENTITY mobilization|nmod|subfractions Effect|nmod|mobilization Effect|nmod|cells cells|nummod|END_ENTITY	Effect of rhG-CSF on the mobilization of CD38 and HLA-DR subfractions of CD34 + peripheral blood progenitor cells .
7613494	0	CD38	34,38	CD34	68,72	CD38	CD34	952	947	Gene	Gene	coexpression|nmod|START_ENTITY Comparison|nmod|coexpression antigens|nsubj|Comparison antigens|nmod|+ +|compound|END_ENTITY	Comparison of the coexpression of CD38 , CD33 and HLA-DR antigens on CD34 + purified cells from human cord blood and bone marrow .
7684620	0	CD38	83,87	CD34	76,80	CD38	CD34	952	947	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	A murine stromal cell line allows the proliferation of very primitive human CD34 + + / CD38 - progenitor cells in long-term cultures and semisolid assays .
8632913	0	CD38	101,105	CD34	90,94	CD38	CD34	952	947	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Tnk1 : a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34 + / Lin - / CD38 - stem/progenitor cells .
8676076	0	CD38	49,53	CD34	44,48	CD38	CD34	952	947	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Differential cytokine effects on primitive -LRB- CD34 + CD38 - -RRB- human hematopoietic cells : novel responses to Flt3-ligand and thrombopoietin .
8950234	0	CD38	144,148	CD34	139,143	CD38	CD34	952	947	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	TGF-beta and MIP-1_alpha exert their main inhibitory activity on very primitive CD34 +2 CD38 - cells but show opposite effects on more mature CD34 + CD38 + human hematopoietic progenitors .
9164933	0	CD38	120,124	CD34	114,118	CD38	CD34	952	947	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Thrombopoietin directly and potently stimulates multilineage growth and progenitor cell expansion from primitive -LRB- CD34 + CD38 - -RRB- human bone marrow progenitor cells : distinct and key interactions with the ligands for c-kit and flt3 , and inhibitory effects of TGF-beta and TNF-alpha .
9177436	0	CD38	43,47	CD34	0,4	CD38	CD34	952	947	Gene	Gene	-|compound|START_ENTITY -|nsubj|cells cells|compound|END_ENTITY	CD34 + megakaryoblastic leukaemic cells are CD38 - , but CD61 + and glycophorin A + : improved criteria for diagnosis of AML-M7 ?
9180291	0	CD38	95,99	CD34	24,28	CD38	CD34	952	947	Gene	Gene	expression|nmod|START_ENTITY characterized|nmod|expression characterized|nsubj|analysis analysis|nmod|subpopulations subpopulations|nummod|END_ENTITY	Cytogenetic analysis of CD34 + subpopulations in AML and MDS characterized by the expression of CD38 and CD117 .
9864151	0	CD38	32,36	CD34	19,23	CD38	CD34	952	947	Gene	Gene	progenitors|nsubj|START_ENTITY adult|parataxis|progenitors adult|dep|END_ENTITY	Single adult human CD34 -LRB- + -RRB- / Lin - / CD38 -LRB- - -RRB- progenitors give rise to natural killer cells , B-lineage cells , dendritic cells , and myeloid cells .
11999573	0	CD38	100,104	CD38	116,120	CD38	CD38	952	952	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Induction of apoptosis by cladribine -LRB- 2-CdA -RRB- , gemcitabine and other chemotherapeutic drugs on CD34 + / CD38 + and CD34 + / CD38 - hematopoietic progenitor cells : selective effects of doxorubicin and 2-CdA with protection of immature cells .
11999573	0	CD38	116,120	CD38	100,104	CD38	CD38	952	952	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Induction of apoptosis by cladribine -LRB- 2-CdA -RRB- , gemcitabine and other chemotherapeutic drugs on CD34 + / CD38 + and CD34 + / CD38 - hematopoietic progenitor cells : selective effects of doxorubicin and 2-CdA with protection of immature cells .
18549635	0	CD38	120,124	CD38	96,100	CD38	CD38	952	952	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|compound|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
18549635	0	CD38	96,100	CD38	120,124	CD38	CD38	952	952	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	-LSB- Differential expression profiles of MicroRNA during the development of human cord blood CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- cells to CD34 -LRB- + -RRB- CD38 -LRB- + -RRB- cells -RSB- .
22165967	0	CD38	105,109	CD38	89,93	CD38	CD38	952	952	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34 + / CD38 + and CD34 + / CD38 - AML progenitor cells .
22165967	0	CD38	89,93	CD38	105,109	CD38	CD38	952	952	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	The Hsp32 inhibitors SMA-ZnPP and PEG-ZnPP exert major growth-inhibitory effects on D34 + / CD38 + and CD34 + / CD38 - AML progenitor cells .
8021494	0	CD38	56,60	CD39	63,67	CD38	CD39	952	953	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	The A-myb gene is preferentially expressed in tonsillar CD38 + , CD39 - , and sIgM - B lymphocytes and in Burkitt 's _ lymphoma cell lines .
11163640	0	CD38	185,189	CD4	39,42	CD38	CD4	952	920	Gene	Gene	molecules|nummod|START_ENTITY expression|nmod|molecules associated|nmod|expression lymphocytes|parataxis|associated lymphocytes|nsubj|susceptibility susceptibility|nmod|T T|compound|END_ENTITY	Differential susceptibility of resting CD4 -LRB- + -RRB- T lymphocytes to a T-tropic and a macrophage -LRB- M -RRB- - tropic human_immunodeficiency_virus_type_1 is associated with their surface expression of CD38 molecules .
15117448	0	CD38	4,8	CD4	60,63	CD38	CD4	952	920	Gene	Gene	cells|compound|START_ENTITY predict|nsubj|cells predict|dobj|loss loss|compound|END_ENTITY	CD8 + CD38 + T cells but not HIV_type_1 RNA viral load predict CD4 + T cell loss in a predominantly minority female HIV + adolescent population .
15764953	0	CD38	29,33	CD4	104,107	CD38	CD4	952	920	Gene	Gene	upregulation|nmod|START_ENTITY influence|nsubj|upregulation influence|dobj|ability ability|acl|reconstitute reconstitute|dobj|cells cells|nummod|END_ENTITY	Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4 + T cells under successful highly active antiretroviral therapy .
16920929	0	CD38	0,4	CD4	66,69	CD38	CD4	12494(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|survival survival|nmod|cells cells|compound|END_ENTITY	CD38 is required for the peripheral survival of immunotolerogenic CD4 + invariant NK T cells in nonobese diabetic mice .
18257774	0	CD38	0,4	CD4	59,62	CD38	CD4	952	920	Gene	Gene	expression|nummod|START_ENTITY has|nsubj|expression has|dobj|association association|nmod|recovery recovery|compound|END_ENTITY	CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy .
18784457	0	CD38	0,4	CD4	44,47	CD38	CD4	952	920	Gene	Gene	T-cells|compound|START_ENTITY correlate|nsubj|T-cells correlate|nmod|cells cells|nummod|END_ENTITY	CD38 + CD8 + T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals .
19072838	0	CD38	26,30	CD4	91,94	CD38	CD4	952	920	Gene	Gene	START_ENTITY|nmod|count count|compound|END_ENTITY	Close association of CD8 + / CD38 bright with HIV-1 replication and complex relationship with CD4 + T-cell count .
20108768	0	CD38	65,69	CD4	28,31	CD38	CD4	952	920	Gene	Gene	CD8|nmod|START_ENTITY CD8|nsubj|Frequency Frequency|appos|distribution distribution|nmod|+ +|compound|END_ENTITY	-LSB- Frequency , distribution of CD4 + , CD8 + T cells and expression of CD38 in gastric mucosa of HIV_infections -RSB- .
21469087	0	CD38	0,4	CD4	53,56	CD38	CD4	952	920	Gene	Gene	identifies|nsubj|START_ENTITY identifies|dobj|subset subset|compound|END_ENTITY	CD38 identifies a hypo-proliferative IL-13-secreting CD4 + T-cell subset that does not fit into existing naive and memory phenotype paradigms .
21937825	0	CD38	4,8	CD4	0,3	CD38	CD4	952	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD38 + HLA-DR + cells : a predictor of viral set point in Chinese men with primary_HIV_infection who have sex with men .
27100997	0	CD38	14,18	CD4	19,22	CD38	CD4	952	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	CD38 + CD8 + and CD38 + CD4 + T Cells and IFN_Gamma -LRB- +874 -RRB- Polymorphism Are Associated with a Poor Virological Outcome .
7554481	0	CD38	27,31	CD4	22,25	CD38	CD4	952	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	During HIV_infection , CD4 + CD38 + T-cells are the predominant circulating CD4 + subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4 + CD38 - T-cells .
7554481	0	CD38	27,31	CD4	73,76	CD38	CD4	952	920	Gene	Gene	T-cells|compound|START_ENTITY predominant|nsubj|T-cells predominant|acl|circulating circulating|dobj|subset subset|compound|END_ENTITY	During HIV_infection , CD4 + CD38 + T-cells are the predominant circulating CD4 + subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4 + CD38 - T-cells .
7686224	0	CD38	19,23	CD4	90,93	CD38	CD4	952	920	Gene	Gene	cells|compound|START_ENTITY levels|nmod|cells add|nsubj|levels add|nmod|value value|nmod|levels levels|compound|END_ENTITY	Elevated levels of CD38 + CD8 + T cells in HIV_infection add to the prognostic value of low CD4 + T cell levels : results of 6 years of follow-up .
7688270	0	CD38	4,8	CD4	112,115	CD38	CD4	952	920	Gene	Gene	+|compound|START_ENTITY +|nsubj|+ +|ccomp|correlate correlate|nmod|counts counts|nummod|END_ENTITY	CD8 + CD38 + and CD8 + DR + peripheral blood_lymphoid_subsets_of_HIV-infected intravenous drug abusers correlate with CD4 + cell counts and proliferation to mitogens .
7930717	0	CD38	105,109	CD4	159,162	CD38	CD4	952	920	Gene	Gene	development|nmod|START_ENTITY activation|dep|development lymphocyte|dobj|activation lymphocyte|parataxis|associated associated|nmod|levels levels|compound|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
8828739	0	CD38	42,46	CD4	86,89	CD38	CD4	952	920	Gene	Gene	cells|compound|START_ENTITY numbers|nmod|cells predict|nsubj|numbers predict|dobj|decline decline|nmod|cells cells|compound|END_ENTITY	Increased numbers of primed activated CD8 + CD38 + CD45RO + T cells predict the decline of CD4 + T cells in HIV-1-infected patients .
9358102	0	CD38	9,13	CD4	178,181	CD38	CD4	952	920	Gene	Gene	expression|compound|START_ENTITY marker|nsubj|expression marker|nmod|count count|compound|END_ENTITY	Elevated CD38 antigen expression on CD8 + T cells is a stronger marker for the risk of chronic HIV_disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4 + cell count , soluble immune activation markers , or combinations of HLA-DR and CD38 expression .
9621984	0	CD38	21,25	CD4	49,52	CD38	CD4	952	920	Gene	Gene	expression|compound|START_ENTITY meaning|nmod|expression meaning|nmod|+ +|compound|END_ENTITY	Different meaning of CD38 molecule expression on CD4 + and CD8 + cells of children perinatally infected with human_immunodeficiency_virus_type_1_infection surviving longer than five years .
9773872	0	CD38	16,20	CD4	110,113	CD38	CD4	952	920	Gene	Gene	expression|compound|START_ENTITY expression|acl|using using|dobj|expression expression|nmod|T T|compound|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9773872	0	CD38	16,20	CD4	92,95	CD38	CD4	952	920	Gene	Gene	expression|compound|START_ENTITY expression|acl|using using|dobj|expression expression|nummod|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9842886	0	CD38	0,4	CD4	18,21	CD38	CD4	952	920	Gene	Gene	CD45RB|compound|START_ENTITY CD45RB|dep|cells cells|nummod|END_ENTITY	CD38 + CD45RB -LRB- low -RRB- CD4 + T cells : a population of T cells with immune regulatory activities in vitro .
1373957	0	CD38	68,72	CD54	83,87	CD38	CD54	952	3383	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Multiparameter analyses of normal and malignant human plasma cells : CD38 + + , CD56 + , CD54 + , cIg + is the common phenotype of myeloma cells .
1373957	0	CD38	68,72	CD56	76,80	CD38	CD56	952	4684	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Multiparameter analyses of normal and malignant human plasma cells : CD38 + + , CD56 + , CD54 + , cIg + is the common phenotype of myeloma cells .
7545096	0	CD38	205,209	CD56	239,243	CD38	CD56	952	4684	Gene	Gene	+|compound|START_ENTITY molecules|appos|+ molecules|appos|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
10861690	0	CD38	82,86	CD8	90,93	CD38	CD8	952	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Multisite comparison of methods for the quantitation of the surface expression of CD38 on CD8 -LRB- + -RRB- T lymphocytes .
12032270	0	CD38	0,4	CD8	19,22	CD38	CD8	952	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	CD38 expression on CD8 -LRB- + -RRB- T cells as a prognostic marker in vertically HIV-infected pediatric patients .
12882659	0	CD38	64,68	CD8	14,17	CD38	CD8	952	925	Gene	Gene	CD28|nummod|START_ENTITY suppressive|nmod|CD28 suppressive|nsubj|Production Production|nmod|nonlytic nonlytic|compound|END_ENTITY	Production of CD8 + T cell nonlytic suppressive factors by CD28 , CD38 , and HLA-DR subpopulations .
12930365	0	CD38	21,25	CD8	46,49	CD38	CD8	952	925	Gene	Gene	molecules|nummod|START_ENTITY molecules|nmod|T T|compound|END_ENTITY	Increased numbers of CD38 molecules on bright CD8 + T lymphocytes in infectious_mononucleosis caused by Epstein-Barr_virus infection .
12959688	0	CD38	80,84	CD8	88,91	CD38	CD8	952	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Distribution of naive and memory/effector CD4 + T lymphocytes and expression of CD38 on CD8 + T lymphocytes in AIDS patients with tuberculosis .
14727214	0	CD38	0,4	CD8	19,22	CD38	CD8	952	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD38 expression in CD8 + T cells predicts virological failure_in_HIV_type_1-infected children receiving antiretroviral therapy .
14983032	0	CD38	81,85	CD8	86,89	CD38	CD8	952	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Relationship between the frequency of HIV-specific CD8 + T cells and the level of CD38 + CD8 + T cells in untreated HIV-infected individuals .
14983032	7	CD38	1211,1215	CD8	1216,1219	CD38	CD8	952	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The distribution of HIV-specific CD8 + T cells was heavily skewed toward CD38 + CD8 + T cells in patients with a high percentage of CD38 + CD8 + T cells .
15018711	0	CD38	0,4	CD8	19,22	CD38	CD8	952	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	CD38 expression on CD8 T lymphocytes as a marker of residual virus replication in chronically HIV-infected patients receiving antiretroviral therapy .
15117448	0	CD38	4,8	CD8	0,3	CD38	CD8	952	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD38 + T cells but not HIV_type_1 RNA viral load predict CD4 + T cell loss in a predominantly minority female HIV + adolescent population .
18257774	0	CD38	0,4	CD8	19,22	CD38	CD8	952	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy .
18784457	0	CD38	0,4	CD8	5,8	CD38	CD8	952	925	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	CD38 + CD8 + T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals .
19072838	0	CD38	26,30	CD8	21,24	CD38	CD8	952	925	Gene	Gene	association|dep|START_ENTITY association|nmod|+ +|compound|END_ENTITY	Close association of CD8 + / CD38 bright with HIV-1 replication and complex relationship with CD4 + T-cell count .
20017809	0	CD38	13,17	CD8	32,35	CD38	CD8	952	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Relevance of CD38 expression on CD8 T cells to evaluate antiretroviral therapy response in HIV-1-infected youths .
21429312	0	CD38	15,19	CD8	34,37	CD38	CD8	952	925	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|cells cells|nummod|END_ENTITY	-LSB- Expression of CD38 and HLA-DR on CD8 + T cells in pediatric AIDS patients receiving highly active antiretroviral therapy -LRB- HAART -RRB- -RSB- .
21980834	0	CD38	11,15	CD8	31,34	CD38	CD8	952	925	Gene	Gene	measurement|compound|START_ENTITY measurement|nmod|T T|compound|END_ENTITY	Discordant CD38 measurement of CD8 + T lymphocytes using fluorescein conjugates in comparison with phycoerythrin conjugates .
23028866	0	CD38	17,21	CD8	57,60	CD38	CD8	12494(Tax:10090)	925	Gene	Gene	demarcates|nsubj|START_ENTITY demarcates|dobj|cells cells|compound|END_ENTITY	Ectonucleotidase CD38 demarcates regulatory , memory-like CD8 + T cells with IFN-y-mediated suppressor activities .
24587800	0	CD38	88,92	CD8	9,12	CD38	CD8	952	925	Gene	Gene	Context|nmod|START_ENTITY Markers|nmod|Context Level|parataxis|Markers Level|nmod|Activation Activation|compound|END_ENTITY	Level of CD8 T Lymphocytes Activation in HIV-Infected Pregnant Women : In the Context of CD38 and HLA-DR Activation Markers .
25000587	0	CD38	32,36	CD8	46,49	CD38	CD8	952	925	Gene	Gene	role|nmod|START_ENTITY role|parataxis|T T|compound|END_ENTITY	Potential role for HIV-specific CD38 - / HLA-DR + CD8 + T cells in viral suppression and cytotoxicity in HIV controllers .
26289091	0	CD38	87,91	CD8	28,31	CD38	CD8	952	925	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|Dysfunction Dysfunction|nmod|T T|compound|END_ENTITY	Dysfunction of PSA-specific CD8 -LRB- + -RRB- T cells in prostate_cancer patients correlates with CD38 and Tim-3 expression .
26289091	0	CD38	87,91	CD8	28,31	CD38	CD8	952	925	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|Dysfunction Dysfunction|nmod|T T|compound|END_ENTITY	Dysfunction of PSA-specific CD8 -LRB- + -RRB- T cells in prostate_cancer patients correlates with CD38 and Tim-3 expression .
26586704	0	CD38	80,84	CD8	104,107	CD38	CD8	952	925	Gene	Gene	Perforin|nummod|START_ENTITY Expression|nmod|Perforin Associated|nmod|Expression Associated|nmod|Lymphocytes Lymphocytes|compound|END_ENTITY	Advanced Lung_Cancer Is Associated with Decreased Expression of Perforin , CD95 , CD38 by Circulating CD3 + CD8 + T Lymphocytes .
27100997	0	CD38	0,4	CD8	5,8	CD38	CD8	952	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD38 + CD8 + and CD38 + CD4 + T Cells and IFN_Gamma -LRB- +874 -RRB- Polymorphism Are Associated with a Poor Virological Outcome .
7545096	0	CD38	205,209	CD8	126,129	CD38	CD8	952	925	Gene	Gene	+|compound|START_ENTITY molecules|appos|+ increased|nmod|molecules increased|dobj|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7545096	0	CD38	205,209	CD8	245,248	CD38	CD8	952	925	Gene	Gene	+|compound|START_ENTITY molecules|appos|+ molecules|appos|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7686224	0	CD38	19,23	CD8	25,28	CD38	CD8	952	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated levels of CD38 + CD8 + T cells in HIV_infection add to the prognostic value of low CD4 + T cell levels : results of 6 years of follow-up .
7688270	0	CD38	4,8	CD8	0,3	CD38	CD8	952	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD8 + CD38 + and CD8 + DR + peripheral blood_lymphoid_subsets_of_HIV-infected intravenous drug abusers correlate with CD4 + cell counts and proliferation to mitogens .
7930717	0	CD38	105,109	CD8	0,3	CD38	CD8	952	925	Gene	Gene	development|nmod|START_ENTITY activation|dep|development lymphocyte|dobj|activation lymphocyte|nsubj|+ +|compound|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
7930717	0	CD38	105,109	CD8	111,114	CD38	CD8	952	925	Gene	Gene	development|nmod|START_ENTITY activation|dep|development lymphocyte|dobj|activation lymphocyte|parataxis|associated associated|nsubjpass|cells cells|compound|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
8454874	0	CD38	56,60	CD8	25,28	CD38	CD8	952	925	Gene	Gene	antigens|compound|START_ENTITY express|dobj|antigens express|nsubj|cells cells|compound|END_ENTITY	Circulating HIV-specific CD8 + cytotoxic T cells express CD38 and HLA-DR antigens .
8809474	0	CD38	44,48	CD8	71,74	CD38	CD8	952	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Elevated relative fluorescence intensity of CD38 antigen expression on CD8 + T cells is a marker of poor prognosis in HIV_infection : results of 6 years of follow-up .
8828739	0	CD38	42,46	CD8	38,41	CD38	CD8	952	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased numbers of primed activated CD8 + CD38 + CD45RO + T cells predict the decline of CD4 + T cells in HIV-1-infected patients .
9083895	0	CD38	91,95	CD8	87,90	CD38	CD8	952	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8 + CD95 + , CD8 + CD38 + , and CD4 + CD95 + T cells are markers for HIV-1_infection and clinical status .
9358102	0	CD38	9,13	CD8	36,39	CD38	CD8	952	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Elevated CD38 antigen expression on CD8 + T cells is a stronger marker for the risk of chronic HIV_disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4 + cell count , soluble immune activation markers , or combinations of HLA-DR and CD38 expression .
9458031	0	CD38	52,56	CD8	48,51	CD38	CD8	952	925	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Monitoring of cytomegalovirus infections by the CD8 + CD38 + T-cell subset in kidney transplant recipients .
9773872	0	CD38	16,20	CD8	54,57	CD38	CD8	952	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9773873	0	CD38	0,4	CD8	33,36	CD38	CD8	952	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD38 expression on cryopreserved CD8 + T cells predicts HIV_disease_progression .
23055153	0	CD38	8,12	CD82	68,72	CD38	CD82	12494(Tax:10090)	12521(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	CD34 ___ / CD38 ___ acute_myelogenous_leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells .
10480436	0	CD38	69,73	Fas_ligand	0,10	CD38	Fas ligand	952	356	Gene	Gene	survival|nmod|START_ENTITY promotes|dobj|survival promotes|nsubj|END_ENTITY	Fas_ligand promotes cell survival of immature human bone marrow CD34 + CD38 - hematopoietic progenitor cells by suppressing apoptosis .
23874626	0	CD38	70,74	Foxp3	77,82	CD38	Foxp3	952	50943	Gene	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	Changes in natural Foxp3 -LRB- + -RRB- Treg but not mucosally-imprinted CD62L -LRB- neg -RRB- CD38 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Treg in the circulation of celiac_disease patients .
7520470	0	CD38	59,63	Interferon_gamma	0,16	CD38	Interferon gamma	952	3458	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interferon_gamma selectively inhibits very primitive CD342 + CD38 - and not more mature CD34 + CD38 + human hematopoietic progenitor cells .
26557732	0	CD38	141,145	Interleukin_10	61,75	CD38	Interleukin 10	952	3586	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Effect of Stress-Free Therapy on immune system : Induction of Interleukin_10 expression in lymphocytes through activation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B Cells .
17164398	0	CD38	0,4	TNF-alpha	32,41	CD38	TNF-alpha	952	7124	Gene	Gene	required|nsubjpass|START_ENTITY required|advcl|priming priming|nmod|END_ENTITY	CD38 is required for priming by TNF-alpha : a mechanism for extracellular coordination of cell fate .
17322278	0	CD38	18,22	TNF-alpha	0,9	CD38	TNF-alpha	952	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNF-alpha induced CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors NF-kappaB and AP-1 .
9654134	0	CD38	67,71	Thrombin	0,8	CD38	Thrombin	952	2147	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	Thrombin induces the association of cyclic_ADP-ribose-synthesizing CD38 with the platelet cytoskeleton .
15266023	0	CD38	172,176	Tumor_necrosis_factor-alpha	0,27	CD38	Tumor necrosis factor-alpha	952	7124	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway regulates|nmod|activation regulates|nsubj|differentially differentially|amod|END_ENTITY	Tumor_necrosis_factor-alpha differentially regulates the expression of proinflammatory genes in human airway_smooth_muscle cells by activation of interferon-beta-dependent CD38 pathway .
17701587	0	CD38	94,98	ZAP-70	87,93	CD38	ZAP-70	952	7535	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Multi-drug resistance mediated by P-glycoprotein overexpression is not correlated with ZAP-70 / CD38 expression in B-cell_chronic_lymphocytic_leukemia .
18974118	0	CD38	21,25	c-Cbl	0,5	CD38	c-Cbl	952	867	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	c-Cbl interacts with CD38 and promotes retinoic_acid-induced differentiation and G0 arrest of human myeloblastic_leukemia cells .
19635790	0	CD38	90,94	c-Cbl	0,5	CD38	c-Cbl	952	867	Gene	Gene	abolishes|nmod|START_ENTITY abolishes|nsubj|G306E G306E|amod|END_ENTITY	c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic_acid-induced cell differentiation and G0 arrest .
19635790	0	CD38	90,94	c-Cbl	79,84	CD38	c-Cbl	952	867	Gene	Gene	abolishes|nmod|START_ENTITY abolishes|dobj|interaction interaction|nmod|END_ENTITY	c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic_acid-induced cell differentiation and G0 arrest .
8576149	0	CD38	94,98	c-cbl	32,37	CD38	c-cbl	952	867	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|phosphorylation phosphorylation|nmod|product product|amod|END_ENTITY	Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells .
15556942	0	CD38	14,18	interleukin-8	22,35	CD38	interleukin-8	952	3576	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Activation of CD38 by interleukin-8 signaling regulates intracellular Ca2 + level and motility of lymphokine-activated killer cells .
21390257	0	CD38	40,44	p110	9,13	CD38	p110	12494(Tax:10090)	18706(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The PI3K p110 regulates expression of CD38 on regulatory T cells .
16291871	0	CD38	0,4	tumor_necrosis_factor-alpha	71,98	CD38	tumor necrosis factor-alpha	952	7124	Gene	Gene	expression|compound|START_ENTITY insensitive|nsubj|expression insensitive|xcomp|steroid steroid|nmod|cells cells|acl|treated treated|nmod|END_ENTITY	CD38 expression is insensitive to steroid action in cells treated with tumor_necrosis_factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform .
16571778	0	CD38	30,34	tumor_necrosis_factor-alpha	49,76	CD38	tumor necrosis factor-alpha	952	7124	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Transcriptional regulation of CD38 expression by tumor_necrosis_factor-alpha in human airway smooth muscle cells : role of NF-kappaB and sensitivity to glucocorticoids .
24752698	0	CD39	47,51	CD134	38,43	CD39	CD134	953	7293	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
19427686	0	CD39	83,87	CD25	4,8	CD39	CD25	12495(Tax:10090)	16184(Tax:10090)	Gene	Gene	suppress|nmod|START_ENTITY +|ccomp|suppress +|nsubj|END_ENTITY	CD4 + CD25 + regulatory T cells suppress contact_hypersensitivity reactions through a CD39 , adenosine-dependent mechanism .
20977632	0	CD39	14,18	CD25	50,54	CD39	CD25	953	3559	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression of CD39 by human peripheral blood CD4 + CD25 + T cells denotes a regulatory memory phenotype .
24752698	0	CD39	47,51	CD25	30,34	CD39	CD25	953	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
26467610	0	CD39	135,139	CD25	90,94	CD39	CD25	953	3669	Gene	Gene	expression|nmod|START_ENTITY identified|nmod|expression cells|acl|identified subsets|dobj|cells subsets|nmod|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
8021494	0	CD39	63,67	CD38	56,60	CD39	CD38	953	952	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	The A-myb gene is preferentially expressed in tonsillar CD38 + , CD39 - , and sIgM - B lymphocytes and in Burkitt 's _ lymphoma cell lines .
19427686	0	CD39	83,87	CD4	0,3	CD39	CD4	12495(Tax:10090)	12504(Tax:10090)	Gene	Gene	suppress|nmod|START_ENTITY +|ccomp|suppress +|nsubj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress contact_hypersensitivity reactions through a CD39 , adenosine-dependent mechanism .
19656134	0	CD39	9,13	CD4	28,31	CD39	CD4	12495(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Isolated CD39 expression on CD4 + T cells denotes both regulatory and memory populations .
19957514	0	CD39	29,33	CD4	24,27	CD39	CD4	953	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Expression of FOXP3 in CD4 + CD39 + T cells of patients with systemic_lupus_erythematosus and dynamic observation of treatment with glucocorticoid -RSB- .
20977632	0	CD39	14,18	CD4	45,48	CD39	CD4	953	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression of CD39 by human peripheral blood CD4 + CD25 + T cells denotes a regulatory memory phenotype .
21513715	0	CD39	24,28	CD4	20,23	CD39	CD4	953	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Separation of human CD4 + CD39 + T cells by magnetic beads reveals two phenotypically and functionally different subsets .
21967895	0	CD39	22,26	CD4	27,30	CD39	CD4	953	920	Gene	Gene	Segregated|dobj|START_ENTITY Segregated|nsubj|function function|compound|END_ENTITY	Segregated regulatory CD39 + CD4 + T cell function : TGF-b-producing Foxp3 - and IL-10-producing Foxp3 + cells are interdependent for protection against collagen-induced_arthritis .
22349724	0	CD39	10,14	CD4	29,32	CD39	CD4	953	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Increased CD39 expression on CD4 -LRB- + -RRB- T lymphocytes has clinical and prognostic significance in chronic_lymphocytic_leukemia .
22585562	0	CD39	50,54	CD4	45,48	CD39	CD4	953	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
22585562	0	CD39	72,76	CD4	67,70	CD39	CD4	953	920	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
23409198	0	CD39	13,17	CD4	21,24	CD39	CD4	953	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion in CD39 CD4 immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological_complications .
24749746	0	CD39	11,15	CD4	6,9	CD39	CD4	953	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD39 + regulatory T cells produce adenosine upon co-expression of surface CD73_or contact with CD73 + exosomes or CD73 + cells .
24752698	0	CD39	47,51	CD4	23,26	CD39	CD4	953	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
26467610	0	CD39	135,139	CD4	84,87	CD39	CD4	953	920	Gene	Gene	expression|nmod|START_ENTITY identified|nmod|expression cells|acl|identified subsets|dobj|cells subsets|nmod|CD25 CD25|compound|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
24749746	0	CD39	11,15	CD73	105,109	CD39	CD73	953	4907	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|nmod|exosomes exosomes|nummod|+ +|compound|END_ENTITY	Human CD4 + CD39 + regulatory T cells produce adenosine upon co-expression of surface CD73_or contact with CD73 + exosomes or CD73 + cells .
25127858	0	CD39	41,45	CD73	46,50	CD39	CD73	953	4907	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Role of TGF-b signaling in generation of CD39 + CD73 + myeloid cells in tumors .
23359087	0	CD39	0,4	CD8	84,87	CD39	CD8	953	925	Gene	Gene	involved|nsubjpass|START_ENTITY involved|advcl|mediating mediating|dobj|activity activity|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8 + T regulatory lymphocytes .
23606272	0	CD39	0,4	CD8	85,88	CD39	CD8	953	925	Gene	Gene	involved|nsubjpass|START_ENTITY bovis|dep|involved bovis|dobj|CD39 CD39|compound|END_ENTITY	CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8 -LRB- + -RRB- CD39 -LRB- + -RRB- regulatory T cells .
26485519	0	CD39	0,4	CD8	48,51	CD39	CD8	953	925	Gene	Gene	Expression|compound|START_ENTITY Identifies|nsubj|Expression Identifies|dobj|Cells Cells|compound|END_ENTITY	CD39 Expression Identifies Terminally Exhausted CD8 + T Cells .
26549640	0	CD39	23,27	CD8	42,45	CD39	CD8	953	925	Gene	Gene	expression|compound|START_ENTITY NADH|dobj|expression NADH|nmod|T T|compound|END_ENTITY	NADH oxidase-dependent CD39 expression by CD8 -LRB- + -RRB- T cells modulates interferon_gamma responses via generation of adenosine .
26823801	0	CD39	40,44	CD8	48,51	CD39	CD8	953	925	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Overexpression of CD39 and high tumoral CD39 -LRB- + -RRB- / CD8 -LRB- + -RRB- ratio are associated with adverse prognosis in resectable gastric_cancer .
19308674	0	CD39	59,63	ENTPD1	65,71	CD39	ENTPD1	12495(Tax:10090)	12495(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Vascular smooth muscle cell expression of ectonucleotidase CD39 -LRB- ENTPD1 -RRB- is required for neointimal formation in mice .
23901069	0	CD39	27,31	ENTPD1	33,39	CD39	ENTPD1	953	953	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of ecto-apyrase CD39 -LRB- ENTPD1 -RRB- expression by phosphodiesterase III -LRB- PDE3 -RRB- .
19957514	0	CD39	29,33	FOXP3	15,20	CD39	FOXP3	953	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	-LSB- Expression of FOXP3 in CD4 + CD39 + T cells of patients with systemic_lupus_erythematosus and dynamic observation of treatment with glucocorticoid -RSB- .
22585562	0	CD39	50,54	FOXP3	56,61	CD39	FOXP3	953	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
26467610	0	CD39	135,139	FOXP3	56,61	CD39	FOXP3	953	50943	Gene	Gene	expression|nmod|START_ENTITY identified|nmod|expression cells|acl|identified subsets|dobj|cells subsets|nsubj|usage usage|appos|expression expression|nmod|Treg Treg|compound|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
20487644	0	CD39	56,60	FoxP3	47,52	CD39	FoxP3	953	50943	Gene	Gene	characteristic|dep|START_ENTITY characteristic|nmod|END_ENTITY	-LSB- Phenotypical and functional characteristic of FoxP3 -LRB- + -RRB- ; CD39 -LRB- + -RRB- ; regulatory T cells in humans -RSB- .
21047964	0	CD39	90,94	FoxP3	109,114	CD39	FoxP3	953	50943	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV_infection : CD39 expression of FoxP3 + T regulatory cells correlates with progressive_disease .
22489829	0	CD39	14,18	FoxP3	22,27	CD39	FoxP3	953	50943	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Expression of CD39 on FoxP3 + T regulatory cells correlates with progression of HBV_infection .
17449799	0	CD39	31,35	Foxp3	39,44	CD39	Foxp3	953	50943	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Expression of ectonucleotidase CD39 by Foxp3 + Treg cells : hydrolysis of extracellular ATP and immune suppression .
15852226	0	CD39	8,12	NTPDase-1	14,23	CD39	NTPDase-1	12495(Tax:10090)	12495(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of CD39 -LRB- NTPDase-1 -RRB- in thromboregulation , cerebroprotection , and cardioprotection .
9221928	0	CD39	76,80	ecto-apyrase	62,74	CD39	ecto-apyrase	953	953	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of brain ecto-apyrase : evidence for only one ecto-apyrase -LRB- CD39 -RRB- gene .
20178980	0	CD39	99,103	ectonucleoside_triphosphate_diphosphohydrolase_1	49,97	CD39	ectonucleoside triphosphate diphosphohydrolase 1	953	953	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	cAMP/CREB-mediated transcriptional regulation of ectonucleoside_triphosphate_diphosphohydrolase_1 -LRB- CD39 -RRB- expression .
15698960	0	CD39L4	86,92	NTPDase5	76,84	CD39L4	NTPDase5	957	957	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Bacterial expression , folding , purification and characterization of soluble NTPDase5 -LRB- CD39L4 -RRB- ecto-nucleotidase .
9606993	0	CD3_epsilon	14,25	RAG-2	47,52	CD3 epsilon	RAG-2	916	5897	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of CD3_epsilon , CD3_zeta , and RAG-1 / RAG-2 in decidual CD56 + NK cells .
8913286	0	CD3_gamma	0,9	CD2	112,115	CD3 gamma	CD2	917	914	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	CD3_gamma , CD3_delta , and CD3_zeta mRNA in adult human marrow hematopoietic progenitors correlates with surface CD2 and CD7 expression .
11123272	0	CD3_zeta	67,75	Fc_gamma_RIII	50,63	CD3 zeta	Fc gamma RIII	12503(Tax:10090)	14131(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of expression and function of Fc_gamma_RIII by CD3_zeta in murine NK cells .
17607320	0	CD3zeta	45,52	B_and_T_lymphocyte_attenuator	0,29	CD3zeta	B and T lymphocyte attenuator	919	151888	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	B_and_T_lymphocyte_attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation .
9878110	0	CD3zeta	34,41	CD4	45,48	CD3zeta	CD4	12503(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Increased Zap-70 association with CD3zeta in CD4 T cells from old mice .
9878110	0	CD3zeta	34,41	Zap-70	10,16	CD3zeta	Zap-70	12503(Tax:10090)	22637(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	Increased Zap-70 association with CD3zeta in CD4 T cells from old mice .
15610307	0	CD3zeta	67,74	caspase-3	95,104	CD3zeta	caspase-3	919	836	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Decreased expression of CD28 coincides with the down-modulation of CD3zeta and augmentation of caspase-3 activity in T cells from hepatocellular_carcinoma-bearing patients and hepatitis_C_virus-infected patients .
16116236	0	CD3zeta	66,73	caspase-3	10,19	CD3zeta	caspase-3	919	836	Gene	Gene	expression|amod|START_ENTITY contribute|nmod|expression contribute|nsubj|expression expression|amod|END_ENTITY	Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic_lupus_erythematosus T cells .
11306146	0	CD4	33,36	4-1BB	100,105	CD4	4-1BB	920	3604	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells expansion|dep|contribution contribution|nmod|END_ENTITY	Differential clonal expansion of CD4 and CD8 T cells in response to 4-1BB ligation : contribution of 4-1BB during inflammatory responses .
11306146	0	CD4	33,36	4-1BB	68,73	CD4	4-1BB	920	3604	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells expansion|nmod|response response|nmod|ligation ligation|nummod|END_ENTITY	Differential clonal expansion of CD4 and CD8 T cells in response to 4-1BB ligation : contribution of 4-1BB during inflammatory responses .
11465097	0	CD4	35,38	4-1BB	76,81	CD4	4-1BB	12504(Tax:10090)	21942(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|nmod|costimulation costimulation|appos|END_ENTITY	Rapid induction of CD95 ligand and CD4 + T cell-mediated apoptosis by CD137 -LRB- 4-1BB -RRB- costimulation .
14527512	0	CD4	72,75	4-1BB	0,5	CD4	4-1BB	12504(Tax:10090)	21942(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY survival|nmod|lymphocytes enhances|dobj|survival enhances|nsubj|cross-linking cross-linking|nummod|END_ENTITY	4-1BB cross-linking enhances the survival and cell cycle progression of CD4 T lymphocytes .
14749528	0	CD4	53,56	4-1BB	27,32	CD4	4-1BB	12504(Tax:10090)	21942(Tax:10090)	Gene	Gene	responses|nummod|START_ENTITY enhances|dobj|responses enhances|nsubj|expression expression|nmod|END_ENTITY	Constitutive expression of 4-1BB on T cells enhances CD4 + T cell responses .
15905521	0	CD4	9,12	4-1BB	53,58	CD4	4-1BB	12504(Tax:10090)	21942(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|nmod|absence absence|nmod|END_ENTITY	Enhanced CD4 T cell responsiveness in the absence of 4-1BB .
16412046	0	CD4	74,77	4-1BB	15,20	CD4	4-1BB	12504(Tax:10090)	21942(Tax:10090)	Gene	Gene	colitis|compound|START_ENTITY modulation|nmod|colitis -4|nmod|modulation -4|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of 4-1BB -LRB- CD137 -RRB- -4 -1 BBligand interaction in the modulation of CD4 T cell-mediated inflammatory colitis .
18727631	0	CD4	30,33	4-1BB	10,15	CD4	4-1BB	920	3604	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Decreased 4-1BB expression on CD4 + CD25 high regulatory T cells in peripheral blood of patients with multiple_sclerosis .
20544034	0	CD4	134,137	4-1BB	8,13	CD4	4-1BB	12504(Tax:10090)	21942(Tax:10090)	Gene	Gene	played|nmod|START_ENTITY played|nsubj|Role Role|nmod|receptor receptor|nummod|END_ENTITY	Role of 4-1BB receptor in the control played by CD8 -LRB- + -RRB- T cells on IFN-gamma production by Mycobacterium_tuberculosis antigen-specific CD4 -LRB- + -RRB- T Cells .
27049955	0	CD4	78,81	4-1BB	0,5	CD4	4-1BB	920	3604	Gene	Gene	Suppression|compound|START_ENTITY Production|dep|Suppression Production|nsubj|Signaling Signaling|nummod|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
22331067	0	CD4	89,92	AP-1	53,57	CD4	AP-1	920	3726	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	IkB kinase b is required for activation of NF-kB and AP-1 in CD3/CD28-stimulated primary CD4 -LRB- + -RRB- T cells .
16840343	0	CD4	120,123	APOBEC3G	92,100	CD4	APOBEC3G	920	60489	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells .
17237417	0	CD4	117,120	APOBEC3G	94,102	CD4	APOBEC3G	920	60489	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4 -LRB- + -RRB- T cells and dendritic cells .
19197360	0	CD4	38,41	APOBEC3G	15,23	CD4	APOBEC3G	920	60489	Gene	Gene	subtypes|compound|START_ENTITY expression|nmod|subtypes expression|nummod|END_ENTITY	Differences in APOBEC3G expression in CD4 + T helper lymphocyte subtypes modulate HIV-1_infectivity .
26987686	0	CD4	100,103	APOBEC3G	82,90	CD4	APOBEC3G	920	60489	Gene	Gene	T-cell|compound|START_ENTITY END_ENTITY|nmod|T-cell	Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4 -LRB- + -RRB- T-cell activation and dendritic cell maturation .
22216188	0	CD4	52,55	Activation-induced_cytidine_deaminase	0,37	CD4	Activation-induced cytidine deaminase	920	57379	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Activation-induced_cytidine_deaminase expression in CD4 + T cells is associated with a unique IL-10-producing subset that increases with age .
12490139	0	CD4	146,149	AhR	123,126	CD4	AhR	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12490139	0	CD4	146,149	AhR	53,56	CD4	AhR	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ aryl_hydrocarbon_receptor|dep|expression aryl_hydrocarbon_receptor|appos|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
21525997	0	CD4	57,60	AhR	103,106	CD4	AhR	920	196	Gene	Gene	T|compound|START_ENTITY favors|nmod|T favors|nsubj|cells cells|nmod|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|appos|END_ENTITY	In vivo dioxin favors interleukin-22 production by human CD4 + T cells in an aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent manner .
22609446	0	CD4	91,94	AhR	31,34	CD4	AhR	920	196	Gene	Gene	cells|amod|START_ENTITY ve|dobj|cells monocytes|acl|ve acts|nmod|monocytes ligand|ccomp|acts ligand|nsubj|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|appos|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AhR -RRB- ligand VAF347 selectively acts on monocytes and na ve CD4 -LRB- + -RRB- Th cells to promote the development of IL-22-secreting Th cells .
26063731	0	CD4	48,51	Androgen_receptor	0,17	CD4	Androgen receptor	920	367	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells modulates|dobj|expression modulates|nsubj|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
22653785	0	CD4	46,49	Aryl_hydrocarbon_receptor	0,25	CD4	Aryl hydrocarbon receptor	920	196	Gene	Gene	cell|compound|START_ENTITY function|nsubj|cell controls|ccomp|function controls|nsubj|END_ENTITY	Aryl_hydrocarbon_receptor controls regulatory CD4 + T cell function .
22898048	0	CD4	20,23	BAFF	0,4	CD4	BAFF	920	10673	Gene	Gene	proliferation|compound|START_ENTITY induces|dobj|proliferation induces|nsubj|END_ENTITY	BAFF induces spleen CD4 + T cell proliferation by down-regulating phosphorylation of FOXO3A and activates cyclin_D2 and D3 expression .
15314041	0	CD4	41,44	BAZF	0,4	CD4	BAZF	12504(Tax:10090)	12029(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells required|nmod|activation required|nsubjpass|END_ENTITY	BAZF is required for activation of naive CD4 T cells by TCR triggering .
21033101	0	CD4	28,31	BCL-2	21,26	CD4	BCL-2	920	596	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
21808017	0	CD4	49,52	BCL6	32,36	CD4	BCL6	920	604	Gene	Gene	subset|compound|START_ENTITY B-cell_lymphoma_6|dep|subset B-cell_lymphoma_6|appos|END_ENTITY	Human tonsil B-cell_lymphoma_6 -LRB- BCL6 -RRB- - expressing CD4 + T-cell subset specialized for B-cell help outside germinal centers .
16272294	0	CD4	67,70	B_and_T_lymphocyte_attenuator	23,52	CD4	B and T lymphocyte attenuator	920	151888	Gene	Gene	+|compound|START_ENTITY engagement|nmod|+ engagement|nsubj|analysis analysis|nmod|END_ENTITY	Functional analysis of B_and_T_lymphocyte_attenuator engagement on CD4 + and CD8 + T cells .
19892849	0	CD4	97,100	B_and_T_lymphocyte_attenuator	35,64	CD4	B and T lymphocyte attenuator	12504(Tax:10090)	208154(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY synapse|nmod|cells accumulation|nmod|synapse accumulation|nmod|END_ENTITY	Activation-induced accumulation of B_and_T_lymphocyte_attenuator at the immunological synapse in CD4 + T cells .
21042564	0	CD4	82,85	B_and_T_lymphocyte_attenuator	19,48	CD4	B and T lymphocyte attenuator	12504(Tax:10090)	208154(Tax:10090)	Gene	Gene	herpetic|compound|START_ENTITY development|nmod|herpetic preventing|dobj|development END_ENTITY|acl|preventing	A crucial role for B_and_T_lymphocyte_attenuator in preventing the development of CD4 + T cell-mediated herpetic stromal_keratitis .
24289156	0	CD4	44,47	B_and_T_lymphocyte_attenuator	0,29	CD4	B and T lymphocyte attenuator	920	151888	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	B_and_T_lymphocyte_attenuator expression on CD4 + T-cells associates with sepsis and subsequent infections in ICU patients .
26329820	0	CD4	48,51	B_and_T_lymphocyte_attenuator	4,33	CD4	B and T lymphocyte attenuator	920	151888	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Low B_and_T_lymphocyte_attenuator expression on CD4 -LRB- + -RRB- T cells in the early stage of sepsis is associated with the severity and mortality of septic patients : a prospective cohort study .
12778345	0	CD4	20,23	Bcl-2	0,5	CD4	Bcl-2	920	596	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|amod|END_ENTITY	Bcl-2 expression by CD4 T lymphocytes in Vogt-Koyanagi-Harada_disease .
17090688	0	CD4	102,105	Bcl-2	14,19	CD4	Bcl-2	920	596	Gene	Gene	line|compound|START_ENTITY differentiation|nmod|line critical|nmod|differentiation critical|nsubj|induction induction|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
19596183	0	CD4	64,67	Bcl-xL	0,6	CD4	Bcl-xL	12504(Tax:10090)	12048(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells required|nmod|development required|nsubjpass|END_ENTITY	Bcl-xL is required for the development of functional regulatory CD4 cells in lupus-afflicted mice following treatment with a tolerogenic peptide .
17307796	0	CD4	57,60	Bcl6	0,4	CD4	Bcl6	12504(Tax:10090)	12053(Tax:10090)	Gene	Gene	T|compound|START_ENTITY generation|nmod|T essential|nmod|generation cells|amod|essential cells|nsubj|END_ENTITY	Bcl6 is essential for the generation of long-term memory CD4 + T cells .
21131418	0	CD4	46,49	Bcl6	0,4	CD4	Bcl6	12504(Tax:10090)	12053(Tax:10090)	Gene	Gene	+|compound|START_ENTITY development|nmod|+ required|nmod|development required|nsubjpass|END_ENTITY	Bcl6 is required for the development of mouse CD4 + and CD8a + dendritic cells .
22427637	0	CD4	59,62	Bcl6	0,4	CD4	Bcl6	920	604	Gene	Gene	T|compound|START_ENTITY differentiation|nsubj|T instruct|xcomp|differentiation cooperate|xcomp|instruct cooperate|nsubj|END_ENTITY	Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation .
23487426	0	CD4	34,37	Bcl6	0,4	CD4	Bcl6	920	604	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory .
23436577	0	CD4	39,42	Beta2-adrenergic_receptor	0,25	CD4	Beta2-adrenergic receptor	920	154	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Beta2-adrenergic_receptor signaling in CD4 + Foxp3 + regulatory T cells enhances their suppressive function in a PKA-dependent manner .
9653079	0	CD4	0,3	C-reactive_protein	30,48	CD4	C-reactive protein	920	1401	Gene	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	CD4 T cell tolerance to human C-reactive_protein , an inducible serum protein , is mediated by medullary thymic epithelium .
25538703	0	CD4	101,104	CAV1	93,97	CD4	CAV1	920	857	Gene	Gene	T-lymphocytes|compound|START_ENTITY END_ENTITY|nmod|T-lymphocytes	Design , Assessment , and in vivo Evaluation of a Computational Model Illustrating the Role of CAV1 in CD4 -LRB- + -RRB- T-lymphocytes .
17881634	0	CD4	71,74	CCL19	13,18	CD4	CCL19	920	6363	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4 + T cells to HIV-1_infection : a novel model of HIV-1 latency .
24588576	0	CD4	38,41	CCL19	83,88	CD4	CCL19	920	6363	Gene	Gene	HIV|nmod|START_ENTITY Entry|nmod|HIV cells|amod|Entry pretreated|nsubj|cells pretreated|nmod|END_ENTITY	Entry of HIV in primary human resting CD4 -LRB- + -RRB- T cells pretreated with the chemokine CCL19 .
10197373	0	CD4	42,45	CCR-5	22,27	CD4	CCR-5	920	1234	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Acute upregulation of CCR-5 expression by CD4 + T lymphocytes in HIV-infected patients treated with interleukin-2 .
12775413	0	CD4	39,42	CCR2	14,18	CD4	CCR2	920	729230	Gene	Gene	cells|compound|START_ENTITY Expression|nmod|cells Expression|nmod|END_ENTITY	Expression of CCR2 , CCR5 , and CXCR3 by CD4 + T cells is stable during a 2-year longitudinal study but varies widely between individuals .
10226056	0	CD4	0,3	CCR3	96,100	CD4	CCR3	920	1232	Gene	Gene	receptor-dependent|nsubj|START_ENTITY receptor-dependent|dep|END_ENTITY	CD4 receptor-dependent entry of human_immunodeficiency_virus_type-1 env-pseudotypes into CCR5 - , CCR3 - , and CXCR4-expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor .
11369641	0	CD4	130,133	CCR3	162,166	CD4	CCR3	920	1232	Gene	Gene	expression|nmod|START_ENTITY susceptible|nmod|expression blood|acl:relcl|susceptible cells/basophils|nmod|blood receptors|nsubj|cells/basophils receptors|dobj|END_ENTITY	Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3 , CCR5 , and CXCR4 .
15379987	0	CD4	15,18	CCR3	20,24	CD4	CCR3	920	1232	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CCR5 + and CD4 + CCR3 + lymphocyte subset and monocyte apoptosis in patients with acute visceral_leishmaniasis .
19302742	0	CD4	79,82	CCR3	55,59	CD4	CCR3	12504(Tax:10090)	12771(Tax:10090)	Gene	Gene	T|compound|START_ENTITY receptors|nmod|T receptors|dep|END_ENTITY	Relationship between expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells and spontaneous_abortion in mice .
19781371	0	CD4	58,61	CCR3	34,38	CD4	CCR3	12504(Tax:10090)	12771(Tax:10090)	Gene	Gene	T|compound|START_ENTITY receptors|nmod|T receptors|dep|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
20659406	0	CD4	28,31	CCR3	20,24	CD4	CCR3	920	1232	Gene	Gene	lymphocytes|nummod|START_ENTITY levels|nmod|lymphocytes levels|nmod|END_ENTITY	Decreased levels of CCR3 in CD4 + lymphocytes of rheumatoid_arthritis patients .
23977659	0	CD4	59,62	CCR3	0,4	CD4	CCR3	920	1232	Gene	Gene	+|compound|START_ENTITY CCR5|nmod|+ CCR5|compound|END_ENTITY	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
11174204	0	CD4	12,15	CCR4	0,4	CD4	CCR4	920	1233	Gene	Gene	lymphocytes|nummod|START_ENTITY lymphocytes|compound|END_ENTITY	CCR4 memory CD4 + T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic_dermatitis .
11359851	0	CD4	27,30	CCR4	19,23	CD4	CCR4	920	1233	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11560999	0	CD4	100,103	CCR4	83,87	CD4	CCR4	920	1233	Gene	Gene	CD25|compound|START_ENTITY chemokine_receptors|nmod|CD25 chemokine_receptors|dep|END_ENTITY	Unique chemotactic response profile and specific expression of chemokine_receptors CCR4 and CCR8 by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells .
12699425	0	CD4	70,73	CCR4	0,4	CD4	CCR4	920	1233	Gene	Gene	cells|compound|START_ENTITY chemokine_receptor|nmod|cells chemokine_receptor|nsubj|END_ENTITY	CCR4 is an up-regulated chemokine_receptor of peripheral blood memory CD4 + T cells in Crohn 's _ disease .
15498047	0	CD4	41,44	CCR4	10,14	CD4	CCR4	920	1233	Gene	Gene	+|compound|START_ENTITY circulating|dobj|+ expression|acl|circulating expression|compound|END_ENTITY	Increased CCR4 expression on circulating CD4 -LRB- + -RRB- T cells in ankylosing_spondylitis , rheumatoid_arthritis and systemic_lupus_erythematosus .
16804321	0	CD4	76,79	CCR4	80,84	CD4	CCR4	920	1233	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Delayed allergic_reaction to suxamethonium driven by oligoclonal Th1-skewed CD4 + CCR4 + IFN-gamma + memory T cells .
17339428	0	CD4	96,99	CCR4	33,37	CD4	CCR4	12504(Tax:10090)	12773(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY accumulation|nmod|cells necessary|nmod|accumulation necessary|nsubj|END_ENTITY	Cutting Edge : Chemokine receptor CCR4 is necessary for antigen-driven cutaneous accumulation of CD4 T cells under physiological conditions .
17442093	0	CD4	34,37	CCR4	42,46	CD4	CCR4	920	1233	Gene	Gene	effective|nmod|START_ENTITY mycosis|ccomp|effective mycosis|nsubj|END_ENTITY	Interferon-alpha is effective for CD4 -LRB- + -RRB- , CCR4 -LRB- - -RRB- mycosis fungoides .
19293635	0	CD4	39,42	CCR4	31,35	CD4	CCR4	920	1233	Gene	Gene	cells|amod|START_ENTITY enhances|nsubj|cells enhances|nsubj|addition addition|nmod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
20412707	0	CD4	84,87	CCR4	27,31	CD4	CCR4	920	1233	Gene	Gene	subpopulation|nmod|START_ENTITY cells|nmod|subpopulation cells|nummod|END_ENTITY	Lower numbers of FoxP3 and CCR4 co-expressing cells in an elevated subpopulation of CD4 + CD25high regulatory T cells from Wegener 's _ granulomatosis .
20963786	0	CD4	127,130	CCR4	113,117	CD4	CCR4	920	1233	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4 + T cells .
22664869	0	CD4	82,85	CCR4	27,31	CD4	CCR4	24932(Tax:10116)	171054(Tax:10116)	Gene	Gene	migration|nmod|START_ENTITY requirements|nmod|migration requirements|nmod|END_ENTITY	Differing requirements for CCR4 , E-selectin , and a4b1 for the migration of memory CD4 and activated T cells to dermal_inflammation .
23977659	0	CD4	59,62	CCR4	6,10	CD4	CCR4	920	1233	Gene	Gene	+|compound|START_ENTITY CCR5|nmod|+ CCR5|appos|END_ENTITY	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
24840326	0	CD4	78,81	CCR4	70,74	CD4	CCR4	403931(Tax:9615)	403541(Tax:9615)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|amod|END_ENTITY	Preferential gene transcription of T helper 2 cytokines in peripheral CCR4 -LRB- + -RRB- CD4 -LRB- + -RRB- lymphocytes in dogs .
24960164	0	CD4	35,38	CCR4	39,43	CD4	CCR4	920	1233	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	HTLV-1 induces a Th1-like state in CD4 + CCR4 + T cells .
25650058	0	CD4	71,74	CCR4	25,29	CD4	CCR4	403931(Tax:9615)	403541(Tax:9615)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells +|nsubj|proportions proportions|nmod|<sup> <sup>|compound|END_ENTITY	Increased proportions of CCR4 <sup> + </sup> cells among peripheral blood CD4 <sup> + </sup> cells and serum levels of allergen-specific IgE antibody in canine chronic rhinitis and bronchitis .
10226056	0	CD4	0,3	CCR5	89,93	CD4	CCR5	920	1234	Gene	Gene	receptor-dependent|nsubj|START_ENTITY receptor-dependent|dep|CCR3 CCR3|nmod|END_ENTITY	CD4 receptor-dependent entry of human_immunodeficiency_virus_type-1 env-pseudotypes into CCR5 - , CCR3 - , and CXCR4-expressing human alveolar macrophages is preferentially mediated by the CCR5 coreceptor .
10413516	0	CD4	86,89	CCR5	53,57	CD4	CCR5	920	1234	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|changes changes|nmod|gp120 gp120|nmod|epitopes epitopes|nmod|site site|compound|END_ENTITY	Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic .
10438877	0	CD4	78,81	CCR5	158,162	CD4	CCR5	920	1234	Gene	Gene	tropism|acl|START_ENTITY determined|nsubj|tropism determined|nmod|capacity capacity|acl|exploit exploit|dobj|concentrations concentrations|nmod|END_ENTITY	Expanded tropism of primary human_immunodeficiency_virus_type_1 R5 strains to CD4 -LRB- + -RRB- T-cell lines determined by the capacity to exploit low concentrations of CCR5 .
10720514	0	CD4	0,3	CCR5	20,24	CD4	CCR5	920	1234	Gene	Gene	surface|compound|START_ENTITY END_ENTITY|nsubj|surface	CD4 + T cell surface CCR5 density as a determining factor of virus_load_in_persons_infected with human_immunodeficiency_virus_type_1 .
10720515	0	CD4	100,103	CCR5	92,96	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Interleukin-2 up-regulates expression of the human_immunodeficiency_virus fusion coreceptor CCR5 by CD4 + lymphocytes in vivo .
10816381	0	CD4	36,39	CCR5	16,20	CD4	CCR5	920	1234	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of CCR5 and CXCR4 with CD4 and gp120 in human blood monocyte-derived dendritic cells .
10864687	0	CD4	33,36	CCR5	40,44	CD4	CCR5	920	1234	Gene	Gene	infection|nmod|START_ENTITY infection|dep|END_ENTITY	CD4-independent infection of two CD4 -LRB- - -RRB- / CCR5 -LRB- - -RRB- / CXCR4 -LRB- + -RRB- pre-T-cell lines by human and simian immunodeficiency viruses .
10961886	0	CD4	123,126	CCR5	22,26	CD4	CCR5	920	1234	Gene	Gene	T|compound|START_ENTITY stimulation|nmod|T up-regulation|nmod|stimulation up-regulation|compound|END_ENTITY	Kinetics of CXCR4 and CCR5 up-regulation and human_immunodeficiency_virus expansion after antigenic stimulation of primary CD4 -LRB- + -RRB- T lymphocytes .
10967018	0	CD4	58,61	CCR5	102,106	CD4	CCR5	920	1234	Gene	Gene	START_ENTITY|appos|CD45RO CD45RO|appos|T T|compound|END_ENTITY	Adenoids provide a microenvironment for the generation of CD4 -LRB- + -RRB- , CD45RO -LRB- + -RRB- , L-selectin -LRB- - -RRB- , CXCR4 -LRB- + -RRB- , CCR5 -LRB- + -RRB- T lymphocytes , a lymphocyte phenotype found in the middle_ear_effusion .
11069995	0	CD4	31,34	CCR5	12,16	CD4	CCR5	920	1234	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Dynamics of CCR5 expression by CD4 -LRB- + -RRB- T cells in lymphoid tissues during simian immunodeficiency_virus_infection .
11181150	0	CD4	56,59	CCR5	22,26	CD4	CCR5	920	1234	Gene	Gene	lymphocytes|compound|START_ENTITY turnover|dep|lymphocytes turnover|nmod|+ +|compound|END_ENTITY	Increased turnover of CCR5 + and redistribution of CCR5 - CD4 T lymphocytes during primary human_immunodeficiency_virus_type_1_infection .
11181150	0	CD4	56,59	CCR5	50,54	CD4	CCR5	920	1234	Gene	Gene	lymphocytes|compound|START_ENTITY turnover|dep|lymphocytes turnover|nmod|END_ENTITY	Increased turnover of CCR5 + and redistribution of CCR5 - CD4 T lymphocytes during primary human_immunodeficiency_virus_type_1_infection .
11500825	0	CD4	79,82	CCR5	29,33	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	A critical role for IL-12 in CCR5 induction on T_cell_receptor-triggered mouse CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
11546936	0	CD4	0,3	CCR5	19,23	CD4	CCR5	920	1234	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	CD4 T cell surface CCR5 density as a host factor in HIV-1_disease_progression .
11751947	0	CD4	79,82	CCR5	17,21	CD4	CCR5	920	1234	Gene	Gene	lymphocytes|compound|START_ENTITY Up-regulation|nmod|lymphocytes Up-regulation|nmod|END_ENTITY	Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4 + T lymphocytes .
11811785	0	CD4	106,109	CCR5	87,91	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	IFN-alpha acts on T-cell_receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4 + and CD8 + T cells .
11839399	0	CD4	78,81	CCR5	51,55	CD4	CCR5	920	1234	Gene	Gene	T|compound|START_ENTITY receptor|nmod|T receptor|compound|END_ENTITY	Oral contraceptive use induces upregulation of the CCR5 chemokine receptor on CD4 -LRB- + -RRB- T cells in the cervical epithelium of healthy women .
12056598	0	CD4	57,60	CCR5	25,29	CD4	CCR5	920	1234	Gene	Gene	lymphocytes|compound|START_ENTITY surface|nmod|lymphocytes receptor|nmod|surface receptor|compound|END_ENTITY	Decreased density of the CCR5 receptor on the surface of CD4 + lymphocytes and monocytes/macrophages is associated with the CCR5-59653T transition in the promoter region .
12131184	0	CD4	103,106	CCR5	0,4	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY uninfected|dobj|cells apoptosis|acl|uninfected mediates|dobj|apoptosis mediates|nsubj|END_ENTITY	CCR5 mediates Fas - and caspase-8 dependent apoptosis of both uninfected and HIV infected primary human CD4 T cells .
12477875	0	CD4	0,3	CCR5	110,114	CD4	CCR5	920	1234	Gene	Gene	antibodies|nummod|START_ENTITY inhibit|nsubj|antibodies inhibit|dobj|interaction interaction|nmod|END_ENTITY	CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5 .
12599050	0	CD4	8,11	CCR5	44,48	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|levels levels|nmod|END_ENTITY	Vaginal CD4 + T cells express high levels of CCR5 and are rapidly depleted in simian immunodeficiency_virus_infection .
12619446	0	CD4	26,29	CCR5	20,24	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased number of CCR5 + CD4 T cells among south Indian adults probably associated with the low frequency of X4 phenotype of HIV-1 in India .
12689415	0	CD4	29,32	CCR5	10,14	CD4	CCR5	713807(Tax:9544)	1234	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Decreased CCR5 expression on CD4 + T cells of SIV-infected sooty mangabeys .
12699431	0	CD4	59,62	CCR5	14,18	CD4	CCR5	920	1234	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of CCR5 expression and MIP-1alpha production in CD4 + T cells from patients with rheumatoid_arthritis .
12865065	0	CD4	51,54	CCR5	15,19	CD4	CCR5	920	1234	Gene	Gene	CD28|compound|START_ENTITY expression|nmod|CD28 expression|nummod|END_ENTITY	Differences in CCR5 expression on peripheral blood CD4 + CD28 - T-cells and in granulomatous_lesions between localized and generalized Wegener 's _ granulomatosis .
12878220	0	CD4	23,26	CCR5	55,59	CD4	CCR5	920	1234	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of soluble CD4 with the chemokine receptor CCR5 .
14607889	0	CD4	20,23	CCR5	82,86	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|migration migration|dep|requirement requirement|nmod|END_ENTITY	Cutting edge : IL-16 / CD4 preferentially induces Th1 cell migration : requirement of CCR5 .
14645006	0	CD4	47,50	CCR5	73,77	CD4	CCR5	920	1234	Gene	Gene	T|compound|START_ENTITY circulating|dobj|T Identification|acl|circulating lymphocytes|nsubj|Identification lymphocytes|nmod|+ +|compound|END_ENTITY	Identification of circulating antigen-specific CD4 + T lymphocytes with a CCR5 + , cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV_infection .
15117454	0	CD4	100,103	CCR5	60,64	CD4	CCR5	920	1234	Gene	Gene	subsets|compound|START_ENTITY expression|nmod|subsets coreceptor|dobj|expression coreceptor|nsubj|Effects Effects|nmod|human_immunodeficiency_virus_type_1_infection human_immunodeficiency_virus_type_1_infection|nmod|END_ENTITY	Effects of human_immunodeficiency_virus_type_1_infection on CCR5 and CXCR4 coreceptor expression on CD4 T lymphocyte subsets in infants and adolescents .
15379987	0	CD4	0,3	CCR5	5,9	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CCR5 + and CD4 + CCR3 + lymphocyte subset and monocyte apoptosis in patients with acute visceral_leishmaniasis .
15459144	0	CD4	19,22	CCR5	13,17	CD4	CCR5	920	1234	Gene	Gene	T-lymphocytes|compound|START_ENTITY T-lymphocytes|compound|END_ENTITY	Expansion of CCR5 + CD4 + T-lymphocytes in the course of active pulmonary_tuberculosis .
15498817	0	CD4	11,14	CCR5	31,35	CD4	CCR5	920	1234	Gene	Gene	cell|compound|START_ENTITY surface|nsubj|cell surface|dobj|expression expression|nummod|END_ENTITY	Diminished CD4 + T cell surface CCR5 expression in alcoholic patients .
15660419	0	CD4	75,78	CCR5	41,45	CD4	CCR5	920	1234	Gene	Gene	presence|nmod|START_ENTITY surface|nmod|presence surface|dobj|END_ENTITY	Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4 .
15905189	0	CD4	58,61	CCR5	23,27	CD4	CCR5	920	1234	Gene	Gene	antigen-specific|dep|START_ENTITY CD38|amod|antigen-specific CD38|compound|END_ENTITY	Early proliferation of CCR5 -LRB- + -RRB- CD38 -LRB- + + + -RRB- antigen-specific CD4 -LRB- + -RRB- Th1 effector cells during primary HIV-1_infection .
16002422	0	CD4	48,51	CCR5	18,22	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY function|nmod|CD25 END_ENTITY|nmod|function	Critical role for CCR5 in the function of donor CD4 + CD25 + regulatory T cells during acute_graft-versus-host_disease .
16249699	0	CD4	50,53	CCR5	56,60	CD4	CCR5	920	1234	Gene	Gene	HIV-1|nmod|START_ENTITY R5_HIV-1|nmod|HIV-1 CXCR4|amod|R5_HIV-1 CXCR4|compound|END_ENTITY	Enhanced replication of R5_HIV-1 over X4 HIV-1 in CD4 -LRB- + -RRB- CCR5 -LRB- + -RRB- CXCR4 -LRB- + -RRB- T cells .
16455991	0	CD4	50,53	CCR5	80,84	CD4	CCR5	920	1234	Gene	Gene	signaling|compound|START_ENTITY dependent|nsubj|signaling dependent|nmod|cholesterol cholesterol|amod|END_ENTITY	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
16791011	0	CD4	54,57	CCR5	73,77	CD4	CCR5	920	1234	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	The efficiency of R5_HIV-1_infection is determined by CD4 T-cell surface CCR5 density through G alpha i-protein signalling .
16899302	0	CD4	28,31	CCR5	33,37	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient Fas expression by CD4 + CCR5 + T cells in multiple_sclerosis .
17003371	0	CD4	11,14	CCR5	15,19	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Paucity of CD4 + CCR5 + T cells is a typical feature of natural SIV hosts .
17520029	0	CD4	53,56	CCR5	16,20	CD4	CCR5	920	1234	Gene	Gene	T|compound|START_ENTITY disrupt|nmod|T disrupt|dobj|levels levels|compound|END_ENTITY	Statins disrupt CCR5 and RANTES expression levels in CD4 -LRB- + -RRB- T lymphocytes in vitro and preferentially decrease infection_of_R5_versus_X4_HIV-1 .
17545708	0	CD4	31,34	CCR5	0,4	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY levels|nmod|cells levels|nummod|END_ENTITY	CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5_HIV-1 .
17765942	0	CD4	56,59	CCR5	82,86	CD4	CCR5	920	1234	Gene	Gene	T|nsubj|START_ENTITY T|xcomp|secrete secrete|dobj|ligands ligands|nummod|END_ENTITY	Antigen stimulation induces HIV envelope gp120-specific CD4 -LRB- + -RRB- T cells to secrete CCR5 ligands and suppress HIV_infection .
17855336	0	CD4	0,3	CCR5	43,47	CD4	CCR5	920	1234	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD4 interacts constitutively with multiple CCR5 at the plasma membrane of living cells .
18025874	0	CD4	29,32	CCR5	40,44	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Early restoration of mucosal CD4 memory CCR5 T cells in the gut of SIV-infected rhesus predicts long term non-progression .
18097220	0	CD4	54,57	CCR5	0,4	CD4	CCR5	920	1234	Gene	Gene	relationship|nmod|START_ENTITY influences|dobj|relationship influences|dep|use use|nsubj|END_ENTITY	CCR5 or CXCR4 use influences the relationship between CD4 cell depletion , NKp44L expression and NK cytotoxicity in SHIV-infected macaques .
18462992	0	CD4	36,39	CCR5	18,22	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Downregulation of CCR5 on activated CD4 T cells in HIV-infected Indians .
19302742	0	CD4	79,82	CCR5	61,65	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	T|compound|START_ENTITY receptors|nmod|T receptors|dep|CCR3 CCR3|nummod|END_ENTITY	Relationship between expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells and spontaneous_abortion in mice .
19781371	0	CD4	58,61	CCR5	40,44	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	T|compound|START_ENTITY receptors|nmod|T receptors|dep|CCR3 CCR3|nummod|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
20381825	0	CD4	27,30	CCR5	19,23	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Constrained use of CCR5 on CD4 + lymphocytes by R5X4_HIV-1 : efficiency of Env-CCR5 interactions and low CCR5 expression determine a range of restricted CCR5-mediated entry .
20560795	0	CD4	89,92	CCR5	30,34	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY effects|nmod|+ has|dobj|effects has|nsubj|blocker blocker|appos|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
20560795	0	CD4	89,92	CCR5	84,88	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
20710056	0	CD4	114,117	CCR5	77,81	CD4	CCR5	920	1234	Gene	Gene	T-cells|compound|START_ENTITY END_ENTITY|nmod|T-cells	GB_virus_C coinfection in advanced HIV_type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4 -LRB- + -RRB- T-cells .
21035160	0	CD4	81,84	CCR5	47,51	CD4	CCR5	713807(Tax:9544)	735311(Tax:9544)	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells expression|nummod|END_ENTITY	TCR triggering transcriptionally downregulates CCR5 expression on rhesus_macaque CD4 -LRB- + -RRB- T-cells with no measurable effect on susceptibility to SIV_infection .
21068438	0	CD4	18,21	CCR5	79,83	CD4	CCR5	920	1234	Gene	Gene	have|nsubj|START_ENTITY have|dobj|pools pools|nmod|END_ENTITY	Circulating human CD4 and CD8 T cells do not have large intracellular pools of CCR5 .
21239363	0	CD4	40,43	CCR5	20,24	CD4	CCR5	920	1234	Gene	Gene	gain|compound|START_ENTITY antagonists|nmod|gain antagonists|nummod|END_ENTITY	The relationship of CCR5 antagonists to CD4 + T-cell gain : a meta-regression of recent clinical trials in treatment-experienced HIV-infected patients .
21291552	0	CD4	100,103	CCR5	104,108	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vaccination with live attenuated simian_immunodeficiency_virus causes dynamic changes in intestinal CD4 + CCR5 + T cells .
21524671	0	CD4	118,121	CCR5	148,152	CD4	CCR5	920	1234	Gene	Gene	usages|compound|START_ENTITY ability|nmod|usages varied|nmod|ability varied|nmod|TAK-779 TAK-779|compound|END_ENTITY	HIV-1 clade C envelopes obtained from late stage symptomatic Indian patients varied in their ability towards relative CD4 usages and sensitivity to CCR5 antagonist TAK-779 .
21715565	0	CD4	78,81	CCR5	54,58	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
22083068	0	CD4	44,47	CCR5	0,4	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY elevated|nmod|cells elevated|nsubjpass|expression expression|compound|END_ENTITY	CCR5 expression is elevated on endocervical CD4 + T cells in healthy postmenopausal women .
23185351	0	CD4	36,39	CCR5	5,9	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY density|nmod|cells density|compound|END_ENTITY	High CCR5 density on central memory CD4 + T cells in acute_HIV-1_infection is mostly associated with rapid disease progression .
23977659	0	CD4	59,62	CCR5	12,16	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	CCR3 , CCR4 , CCR5 , and CXCR3 expression in peripheral blood CD4 + lymphocytes in gastric_cancer patients .
24312168	0	CD4	54,57	CCR5	70,74	CD4	CCR5	920	1234	Gene	Gene	antibodies|nmod|START_ENTITY Detection|nmod|antibodies END_ENTITY|nsubj|Detection	Detection of HIV-1 neutralizing antibodies in a human CD4 / CXCR4 / CCR5 T-lymphoblastoid cell assay system .
24597865	0	CD4	35,38	CCR5	16,20	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY editing|nmod|cells editing|nmod|END_ENTITY	Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV .
24999042	0	CD4	74,77	CCR5	61,65	CD4	CCR5	920	1234	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	HIV replication in conjunction with granzyme_B production by CCR5 + memory CD4 T cells : Implications for bystander cell and tissue pathologies .
25268493	0	CD4	80,83	CCR5	85,89	CD4	CCR5	920	1234	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	The Inner Foreskin of Healthy Males at Risk of HIV Infection Harbors Epithelial CD4 + CCR5 + Cells and Has Features of an Inflamed Epidermal Barrier .
25268698	0	CD4	29,32	CCR5	0,4	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	T|compound|START_ENTITY Editing|nmod|T Editing|compound|END_ENTITY	CCR5 Gene Editing of Resting CD4 -LRB- + -RRB- T Cells by Transient ZFN Expression From HIV Envelope Pseudotyped Nonintegrating Lentivirus Confers HIV-1 Resistance in Humanized Mice .
25495598	0	CD4	30,33	CCR5	14,18	CD4	CCR5	920	1234	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	The number of CCR5 expressing CD4 + T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors : a cross-sectional study .
25550504	0	CD4	10,13	CCR5	14,18	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD4 + CCR5 + T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus_macaques .
25550504	0	CD4	10,13	CCR5	14,18	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD4 + CCR5 + T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus_macaques .
25834861	0	CD4	72,75	CCR5	64,68	CD4	CCR5	920	1234	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ associated|nmod|cells associated|nmod|expression expression|nmod|END_ENTITY	Heroin use in Indonesia is associated with higher expression of CCR5 on CD4 + cells and lower ex-vivo production of CCR5 ligands .
27021296	0	CD4	27,30	CCR5	0,4	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
27026376	0	CD4	72,75	CCR5	0,4	CD4	CCR5	920	1234	Gene	Gene	cells|compound|START_ENTITY depletion|nmod|cells contributes|nmod|depletion contributes|nsubj|interaction interaction|nummod|END_ENTITY	CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo .
9581779	0	CD4	31,34	CCR5	120,124	CD4	CCR5	920	1234	Gene	Gene	lymphocytes|nummod|START_ENTITY Reduced_HIV-1_infectability|nmod|lymphocytes Reduced_HIV-1_infectability|dep|association association|nmod|expression expression|nmod|END_ENTITY	Reduced_HIV-1_infectability of CD4 + lymphocytes from exposed-uninfected individuals : association with low expression of CCR5 and high production of beta-chemokines .
9811784	0	CD4	21,24	CCR5	210,214	CD4	CCR5	920	12774(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|become become|nmod|upregulation upregulation|nmod|END_ENTITY	Human lymphoblastoid CD4 -LRB- + -RRB- T cells become permissive to macrophage-tropic strains of human_immunodeficiency_virus_type_1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5 : in vivo dynamics of CD4 -LRB- + -RRB- T-cell differentiation in pathogenesis of AIDS .
9811784	0	CD4	236,239	CCR5	210,214	CD4	CCR5	12504(Tax:10090)	12774(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY dynamics|nmod|T-cell become|nmod|dynamics become|nmod|upregulation upregulation|nmod|END_ENTITY	Human lymphoblastoid CD4 -LRB- + -RRB- T cells become permissive to macrophage-tropic strains of human_immunodeficiency_virus_type_1 after passage into severe combined immunodeficient mice through in vivo upregulation of CCR5 : in vivo dynamics of CD4 -LRB- + -RRB- T-cell differentiation in pathogenesis of AIDS .
15774622	0	CD4	15,18	CCR6	0,4	CD4	CCR6	920	1235	Gene	Gene	responses|nummod|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	CCR6 regulates CD4 + T-cell-mediated acute_graft-versus-host_disease responses .
15920150	0	CD4	25,28	CCR6	11,15	CD4	CCR6	12504(Tax:10090)	12458(Tax:10090)	Gene	Gene	development|compound|START_ENTITY inhibits|dobj|development inhibits|nsubj|Absence Absence|nmod|END_ENTITY	Absence of CCR6 inhibits CD4 + regulatory T-cell development and M-cell formation inside Peyer 's patches .
16966255	0	CD4	59,62	CCR6	0,4	CD4	CCR6	12504(Tax:10090)	12458(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY function|nmod|cells regulates|dobj|function regulates|nsubj|END_ENTITY	CCR6 regulates the function of alloreactive and regulatory CD4 + T cells during acute_graft-versus-host_disease .
18422729	0	CD4	15,18	CCR6	9,13	CD4	CCR6	920	1235	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Elevated CCR6 + CD4 + T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response .
18706444	0	CD4	23,26	CCR6	28,32	CD4	CCR6	12504(Tax:10090)	12458(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Airway infiltration of CD4 + CCR6 + Th17 type cells associated with chronic cigarette smoke induced airspace enlargement .
19499521	0	CD4	58,61	CCR6	0,4	CD4	CCR6	12504(Tax:10090)	12458(Tax:10090)	Gene	Gene	recruitment|compound|START_ENTITY controlling|dobj|recruitment regulates|advcl|controlling regulates|nsubj|END_ENTITY	CCR6 regulates EAE pathogenesis by controlling regulatory CD4 + T-cell recruitment to target tissues .
20629311	0	CD4	15,18	CCR6	29,33	CD4	CCR6	920	1235	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The change of CD4 + CD25high CCR6 + regulatory T cells in breast_cancer patients -RSB- .
21655250	0	CD4	31,34	CCR6	36,40	CD4	CCR6	12504(Tax:10090)	12458(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In situ prior proliferation of CD4 + CCR6 + regulatory T cells facilitated by TGF-b secreting DCs is crucial for their enrichment and suppression in tumor immunity .
24223818	0	CD4	53,56	CCR6	20,24	CD4	CCR6	12504(Tax:10090)	12458(Tax:10090)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	Chemokine receptors CCR6 and CXCR3 are necessary for CD4 -LRB- + -RRB- T cell mediated ocular_surface_disease in experimental dry_eye_disease .
26807971	0	CD4	55,58	CCR6	43,47	CD4	CCR6	920	1235	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4 + T-cells in HIV-infected individuals on antiretroviral therapy .
10627863	0	CD4	86,89	CCR7	0,4	CD4	CCR7	920	1236	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes receptor|dep|expression receptor|amod|END_ENTITY	CCR7 -LRB- EBI1 -RRB- receptor down-regulation in asthma : differential gene expression in human CD4 + T lymphocytes .
10878344	0	CD4	78,81	CCR7	83,87	CD4	CCR7	920	1236	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Cytokines and cell surface molecules independently induce CXCR4 expression on CD4 + CCR7 + human memory T cells .
11739486	0	CD4	88,91	CCR7	36,40	CD4	CCR7	12504(Tax:10090)	12775(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells influence|dobj|proliferation influence|nsubj|ligand ligand|nmod|END_ENTITY	A ligand for the chemokine receptor CCR7 can influence the homeostatic proliferation of CD4 T cells and progression of autoimmunity .
12023337	0	CD4	42,45	CCR7	76,80	CD4	CCR7	12504(Tax:10090)	12775(Tax:10090)	Gene	Gene	express|nmod|START_ENTITY express|dobj|END_ENTITY	In vivo differentiated cytokine-producing CD4 -LRB- + -RRB- T cells express functional CCR7 .
12193715	0	CD4	21,24	CCR7	125,129	CD4	CCR7	12504(Tax:10090)	12775(Tax:10090)	Gene	Gene	+|compound|START_ENTITY subpopulation|nmod|+ splenocytes|nsubj|subpopulation splenocytes|ccomp|expresses expresses|dobj|levels levels|nmod|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
15147571	0	CD4	125,128	CCR7	14,18	CD4	CCR7	920	1236	Gene	Gene	cells|compound|START_ENTITY bias|nmod|cells helper|dobj|bias T|parataxis|helper T|nsubj|Aberration Aberration|nmod|memory memory|compound|END_ENTITY	Aberration of CCR7 CD8 memory T cells from patients with systemic_lupus_erythematosus : an inducer of T helper type 2 bias of CD4 T cells .
15743472	0	CD4	62,65	CCR7	46,50	CD4	CCR7	920	1236	Gene	Gene	cells|nummod|START_ENTITY characterisation|dep|cells characterisation|nmod|+ +|compound|END_ENTITY	Phenotypic and functional characterisation of CCR7 + and CCR7 - CD4 + memory T cells homing to the joints in juvenile_idiopathic_arthritis .
16272303	0	CD4	28,31	CCR7	72,76	CD4	CCR7	920	1236	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells defined|nsubj|differentiation defined|nmod|expression expression|nmod|END_ENTITY	Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27 .
16826221	0	CD4	27,30	CCR7	92,96	CD4	CCR7	920	1236	Gene	Gene	cells|compound|START_ENTITY cells|dep|expressing expressing|dobj|END_ENTITY	A high proportion of donor CD4 + T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute_graft-versus-host_disease in patients undergoing allogeneic stem cell transplantation for hematological_malignancy .
17371928	0	CD4	45,48	CCR7	0,4	CD4	CCR7	12504(Tax:10090)	12775(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells required|nmod|function required|nsubjpass|END_ENTITY	CCR7 is required for the in vivo function of CD4 + CD25 + regulatory T cells .
18025179	0	CD4	58,61	CCR7	0,4	CD4	CCR7	12504(Tax:10090)	12775(Tax:10090)	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|expression expression|nummod|END_ENTITY	CCR7 expression in developing thymocytes is linked to the CD4 versus CD8 lineage decision .
18166500	0	CD4	77,80	CCR7	27,31	CD4	CCR7	920	1236	Gene	Gene	Tregs|compound|START_ENTITY subsets|nmod|Tregs defines|dobj|subsets defines|nsubj|expression expression|nmod|END_ENTITY	Differential expression of CCR7 defines two distinct subsets of human memory CD4 + CD25 + Tregs .
19040002	0	CD4	72,75	CCR7	11,15	CD4	CCR7	920	1236	Gene	Gene	T|compound|START_ENTITY channel|nmod|T blocking|nmod|channel lymphocytes|advcl|blocking lymphocytes|nsubj|Change Change|nmod|END_ENTITY	-LSB- Change of CCR7 and CD45RA after blocking of Kv1 .3 potassium channel of CD4 + T lymphocytes in multiple_sclerosis -RSB- .
22633193	0	CD4	33,36	CCR7	14,18	CD4	CCR7	920	1236	Gene	Gene	+|compound|START_ENTITY Expression|nmod|+ Expression|nmod|END_ENTITY	Expression of CCR7 and CD45RA in CD4 + and CD8 + subsets in cerebrospinal fluid of 134 patients with inflammatory and non-inflammatory neurological_diseases .
22990666	0	CD4	40,43	CCR7	0,4	CD4	CCR7	920	1236	Gene	Gene	cells|compound|START_ENTITY +|dep|cells +|compound|END_ENTITY	CCR7 + central and CCR7 - effector memory CD4 + T cells in human cutaneous_leishmaniasis .
23935190	0	CD4	64,67	CCR7	0,4	CD4	CCR7	12504(Tax:10090)	12775(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY trafficking|nmod|cells role|nmod|trafficking plays|dobj|role plays|nsubj|END_ENTITY	CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes .
24566708	0	CD4	14,17	CCR7	21,25	CD4	CCR7	920	1236	Gene	Gene	/|nsubj|START_ENTITY /|dobj|T-cell T-cell|compound|END_ENTITY	Donor-derived CD4 -LRB- + -RRB- / CCR7 -LRB- + -RRB- T-cell partial selective depletion does not alter acquired anti-infective immunity .
24906571	0	CD4	155,158	CCR7	160,164	CD4	CCR7	920	1236	Gene	Gene	subsets|compound|START_ENTITY subsets|compound|END_ENTITY	-LSB- The impact of donor naive and memory T cell subsets on patient outcome following allogeneic stem cell transplantation : relationship between infused donor CD4 + / CCR7 + T cell subsets and acute_graft-versus-host_disease -RSB- .
25688986	0	CD4	58,61	CCR7	36,40	CD4	CCR7	920	1236	Gene	Gene	Migration|compound|START_ENTITY Migration|compound|END_ENTITY	The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration : CCR7 Homo - and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7 .
25688986	0	CD4	58,61	CCR7	80,84	CD4	CCR7	920	1236	Gene	Gene	Migration|compound|START_ENTITY Migration|dep|Homo Homo|compound|END_ENTITY	The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration : CCR7 Homo - and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7 .
15699124	0	CD4	55,58	CCR8	0,4	CD4	CCR8	12504(Tax:10090)	12776(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	CCR8 is expressed by antigen-elicited , IL-10-producing CD4 + CD25 + T cells , which regulate Th2-mediated granuloma formation in mice .
17082609	0	CD4	27,30	CCR8	0,4	CD4	CCR8	920	1237	Gene	Gene	cells|nummod|START_ENTITY identifies|dobj|cells identifies|nsubj|expression expression|compound|END_ENTITY	CCR8 expression identifies CD4 memory T cells enriched for FOXP3 + regulatory and Th2 effector lymphocytes .
17082609	8	CD4	998,1001	CCR8	993,997	CD4	CCR8	12504(Tax:10090)	12776(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Two-thirds of CCR8 + CD4 T cells express cutaneous lymphocyte-associated Ag while the majority lack gut-homing receptors .
17947648	0	CD4	56,59	CCR8	116,120	CD4	CCR8	920	1237	Gene	Gene	cells|compound|START_ENTITY macrophages|nmod|cells Recruitment|nmod|macrophages Recruitment|dep|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Recruitment and activation of macrophages by pathogenic CD4 T cells in type 1 diabetes : evidence for involvement of CCR8 and CCL1 .
14559839	0	CD4	77,80	CCR9	69,73	CD4	CCR9	920	10803	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Selectively increased expression and functions of chemokine receptor CCR9 on CD4 + T cells from patients with T-cell_lineage_acute_lymphocytic_leukemia .
18453568	0	CD4	22,25	CCR9	14,18	CD4	CCR9	12504(Tax:10090)	12769(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells .
26616645	0	CD4	36,39	CCR9	0,4	CD4	CCR9	920	10803	Gene	Gene	CD8|compound|START_ENTITY over-expressed|nmod|CD8 thymocytes|amod|over-expressed thymocytes|nsubj|END_ENTITY	CCR9 and CCR7 are over-expressed in CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes of myasthenia_gravis patients .
11930315	0	CD4	56,59	CC_chemokine_receptor_5	76,99	CD4	CC chemokine receptor 5	920	1234	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	Response to treatment and disease progression linked to CD4 + T cell surface CC_chemokine_receptor_5 density in human_immunodeficiency_virus_type_1_vertical_infection .
15220427	0	CD4	54,57	CC_chemokine_receptor_7	0,23	CD4	CC chemokine receptor 7	920	1236	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	CC_chemokine_receptor_7 expression by effector/memory CD4 + T cells depends on antigen specificity and tissue localization during influenza_A_virus infection .
1375001	0	CD4	100,103	CD1	112,115	CD4	CD1	920	911	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
16116203	0	CD4	84,87	CD103	88,93	CD4	CD103	12504(Tax:10090)	16407(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4 + CD103 + regulatory T cells in vivo .
17513734	0	CD4	127,130	CD103	0,5	CD4	CD103	12504(Tax:10090)	16407(Tax:10090)	Gene	Gene	+|compound|START_ENTITY presenting|nmod|+ specialized|advcl|presenting specialized|nsubj|cells cells|amod|END_ENTITY	CD103 - and CD103 + bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4 + and CD8 + T cells .
18550852	0	CD4	24,27	CD103	18,23	CD4	CD103	920	3682	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vivo-activated CD103 + CD4 + regulatory T cells ameliorate ongoing chronic_graft-versus-host_disease .
19553521	0	CD4	35,38	CD103	15,20	CD4	CD103	12504(Tax:10090)	16407(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-2 regulates CD103 expression on CD4 + T cells in Scurfy mice that display both CD103-dependent and independent inflammation .
20599216	0	CD4	13,16	CD103	51,56	CD4	CD103	12504(Tax:10090)	16407(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Induction|nmod|CD25 T|nsubj|Induction T|nmod|depletion depletion|compound|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells with CD103 depletion .
20824715	0	CD4	15,18	CD103	27,32	CD4	CD103	920	3682	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tumor-reactive CD4 + CD8ab + CD103 + abT cells : a prevalent tumor-reactive T-cell subset in metastatic colorectal_cancers .
21908266	0	CD4	79,82	CD103	11,16	CD4	CD103	12504(Tax:10090)	16407(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY induce|dobj|responses induce|nsubj|+ +|compound|END_ENTITY	Mouse lung CD103 + and CD11bhigh dendritic cells preferentially induce distinct CD4 + T-cell responses .
23733880	0	CD4	149,152	CD103	78,83	CD4	CD103	12504(Tax:10090)	16407(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY novo|nmod|cells induce|dobj|novo retinaldehyde|advcl|induce retinaldehyde|dobj|cells cells|amod|dehydrogenase dehydrogenase|nmod|+ +|compound|END_ENTITY	Cutting edge : inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103 + but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4 + T cells and promote airway tolerance .
25308332	0	CD4	0,3	CD103	37,42	CD4	CD103	920	3682	Gene	Gene	T|compound|START_ENTITY T|dep|formation formation|nmod|T T|compound|END_ENTITY	CD4 + T cell help guides formation of CD103 + lung-resident memory CD8 + T cells during influenza viral_infection .
12064793	0	CD4	56,59	CD11a	17,22	CD4	CD11a	920	3683	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Up-regulation of CD11a -LRB- LFA-1 -RRB- expression on peripheral CD4 + T cells in primary_biliary_cirrhosis .
25414732	0	CD4	55,58	CD11a	45,50	CD4	CD11a	920	3683	Gene	Gene	ITGAL|nmod|START_ENTITY ITGAL|appos|END_ENTITY	Hypomethylation and overexpression of ITGAL -LRB- CD11a -RRB- in CD4 -LRB- + -RRB- T cells in systemic_sclerosis .
1387727	0	CD4	45,48	CD11b	14,19	CD4	CD11b	920	3684	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|nmod|antigen antigen|amod|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
17173927	0	CD4	6,9	CD127	85,90	CD4	CD127	920	3575	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|express express|dobj|levels levels|nmod|chain chain|appos|END_ENTITY	Human CD4 + regulatory T cells express lower levels of the IL-7 receptor alpha chain -LRB- CD127 -RRB- , allowing consistent identification and sorting of live cells .
18390743	0	CD4	34,37	CD127	0,5	CD4	CD127	920	3575	Gene	Gene	subsets|compound|START_ENTITY defines|dobj|subsets defines|nsubj|END_ENTITY	CD127 and CD25 expression defines CD4 + T cell subsets that are differentially depleted during HIV_infection .
18406576	0	CD4	41,44	CD127	0,5	CD4	CD127	920	3575	Gene	Gene	regulation|compound|START_ENTITY suggests|dobj|regulation suggests|nsubj|immunophenotyping immunophenotyping|compound|END_ENTITY	CD127 immunophenotyping suggests altered CD4 + T cell regulation in primary progressive multiple_sclerosis .
18576316	0	CD4	8,11	CD127	83,88	CD4	CD127	920	3575	Gene	Gene	+|compound|START_ENTITY +|dep|sensitivity sensitivity|nmod|CD4 CD4|nummod|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
20690182	0	CD4	46,49	CD127	10,15	CD4	CD127	920	3575	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Increased CD127 expression on activated FOXP3 + CD4 + regulatory T cells .
20935556	0	CD4	39,42	CD127	8,13	CD4	CD127	920	3575	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Reduced CD127 expression on peripheral CD4 + T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapy .
21799858	0	CD4	23,26	CD127	100,105	CD4	CD127	920	3575	Gene	Gene	Requirement|nmod|START_ENTITY +|nsubj|Requirement +|nmod|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21802372	0	CD4	52,55	CD127	65,70	CD4	CD127	920	3575	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Identification of FOXP3-negative regulatory T-like -LRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- -RRB- cells in patients with immune_dysregulation , _ polyendocrinopathy , _ enteropathy , _ X-linked_syndrome .
22122423	0	CD4	30,33	CD127	62,67	CD4	CD127	920	3575	Gene	Gene	proportions|nmod|START_ENTITY Changes|nmod|proportions T|nsubj|Changes T|dobj|subsets subsets|acl|defined defined|nmod|expression expression|compound|END_ENTITY	Changes in the proportions of CD4 -LRB- + -RRB- T cell subsets defined by CD127 and CD25 expression during HBV_infection .
23257455	0	CD4	13,16	CD127	26,31	CD4	CD127	12504(Tax:10090)	16197(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Analysis|nmod|CD25 END_ENTITY|nsubj|Analysis	-LSB- Analysis of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- Treg cells in mice -RSB- .
23466550	0	CD4	28,31	CD127	45,50	CD4	CD127	920	3575	Gene	Gene	CD25|compound|START_ENTITY medium|nmod|CD25 Impact|nmod|medium END_ENTITY|nsubj|Impact	Impact of culture medium on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- lo/neg -RRB- Treg expansion for the purpose of clinical application .
24348676	0	CD4	30,33	CD127	10,15	CD4	CD127	920	3575	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells expression|compound|END_ENTITY	Decreased CD127 expression on CD4 + T-cells and elevated frequencies of CD4 + CD25 + CD127 - T-cells in children with long-lasting type_1_diabetes .
26333292	0	CD4	12,15	CD127	27,32	CD4	CD127	920	3575	Gene	Gene	CD25|compound|START_ENTITY Decrease|nmod|CD25 FoxP3|amod|Decrease FoxP3|compound|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
15111929	0	CD4	65,68	CD134	69,74	CD4	CD134	920	7293	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 -LRB- OX40 -RRB- T-cell subsets in acute_graft-versus-host_disease .
15326292	0	CD4	48,51	CD134	70,75	CD4	CD134	920	7293	Gene	Gene	cells|compound|START_ENTITY targets|dobj|cells targets|advcl|using using|dobj|END_ENTITY	Feline_immunodeficiency_virus targets activated CD4 + T cells by using CD134 as a binding receptor .
15591118	0	CD4	30,33	CD134	20,25	CD4	CD134	920	7293	Gene	Gene	CD25|compound|START_ENTITY OX40|nmod|CD25 OX40|appos|END_ENTITY	Triggering of OX40 -LRB- CD134 -RRB- on CD4 -LRB- + -RRB- CD25 + T cells blocks their inhibitory activity : a novel regulatory role for OX40 and its comparison with GITR .
16176850	0	CD4	14,17	CD134	41,46	CD4	CD134	920	7293	Gene	Gene	Regulation|nmod|START_ENTITY T|nsubj|Regulation T|nmod|OX40 OX40|appos|END_ENTITY	Regulation of CD4 T cell memory by OX40 -LRB- CD134 -RRB- .
16367941	0	CD4	30,33	CD134	20,25	CD4	CD134	920	7293	Gene	Gene	T-cells|compound|START_ENTITY Expression|nmod|T-cells Expression|appos|END_ENTITY	Expression of OX40 -LRB- CD134 -RRB- on CD4 + T-cells from patients with myasthenia_gravis .
16541471	0	CD4	50,53	CD134	6,11	CD4	CD134	920	7293	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells engagement|dobj|differentiation engagement|nsubj|OX40 OX40|appos|END_ENTITY	OX40 -LRB- CD134 -RRB- engagement drives differentiation of CD4 + T cells to effector cells .
16879242	0	CD4	20,23	CD134	0,5	CD4	CD134	920	7293	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD134 expression on CD4 + T cells is associated with nephritis and disease activity in patients with systemic_lupus_erythematosus .
18723571	0	CD4	0,3	CD134	40,45	CD4	CD134	920	7293	Gene	Gene	populations|compound|START_ENTITY populations|acl|expressing expressing|dobj|END_ENTITY	CD4 + CD25 + T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener 's _ granulomatosis .
22471609	0	CD4	58,61	CD134	49,54	CD4	CD134	920	7293	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Study on the expression of co-stimulatory marker CD134 on CD4 + T cells in HIV-1-infected individuals .
24752698	0	CD4	23,26	CD134	38,43	CD4	CD134	920	7293	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
24797972	0	CD4	63,66	CD134	25,30	CD4	CD134	920	7293	Gene	Gene	cells|amod|START_ENTITY molecules|nmod|cells molecules|nsubj|expression expression|nmod|OX40 OX40|appos|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
26561553	0	CD4	16,19	CD134	41,46	CD4	CD134	920	7293	Gene	Gene	CD137|compound|START_ENTITY CD137|compound|END_ENTITY	Tumor-Unrelated CD4 T Cell Help Augments CD134 Plus CD137 Dual Costimulation Tumor Therapy .
24797972	0	CD4	63,66	CD137	43,48	CD4	CD137	920	3604	Gene	Gene	cells|amod|START_ENTITY molecules|nmod|cells molecules|nsubj|expression expression|nmod|OX40 OX40|appos|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
22749982	0	CD4	61,64	CD152	13,18	CD4	CD152	920	1493	Gene	Gene	CD25|compound|START_ENTITY Induction|dep|CD25 Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
10684857	0	CD4	42,45	CD154	13,18	CD4	CD154	920	959	Gene	Gene	T|compound|START_ENTITY response|compound|T triggers|dobj|response triggers|nsubj|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- triggers a short-term CD4 -LRB- + -RRB- T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis .
10700427	0	CD4	47,50	CD154	37,42	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Increased expression of CD40 ligand -LRB- CD154 -RRB- on CD4 + T cells as a marker of disease activity in rheumatoid_arthritis .
10725703	0	CD4	54,57	CD154	24,29	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells .
10940889	0	CD4	144,147	CD154	123,128	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|appos|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
12618479	0	CD4	18,21	CD154	56,61	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells role|nmod|source source|nmod|END_ENTITY	A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes_mellitus in the non-obese diabetic mouse .
12857968	0	CD4	50,53	CD154	0,5	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY regulation|nmod|cells transcriptional|dobj|regulation transcriptional|nsubj|END_ENTITY	CD154 transcriptional regulation in primary human CD4 T cells .
14627918	0	CD4	24,27	CD154	0,5	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY surface|nmod|cells END_ENTITY|nmod|surface	CD154 on the surface of CD4 + CD25 + regulatory T cells contributes to skin transplant tolerance .
14645155	0	CD4	39,42	CD154	10,15	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Decreased CD154 expression by neonatal CD4 + T cells is due to limitations in both proximal and distal events of T cell activation .
14702154	0	CD4	52,55	CD154	31,36	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY impaired|nmod|cells impaired|nsubjpass|induction induction|nmod|END_ENTITY	Pathogen-specific induction of CD154 is impaired in CD4 + T cells from human_immunodeficiency_virus-infected patients .
15147360	0	CD4	42,45	CD154	12,17	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY Decrease|nmod|cells Decrease|nmod|intensity intensity|compound|END_ENTITY	Decrease of CD154 intensity on peripheral CD4 + T cells in autoimmune_thyroid_disease .
16186818	0	CD4	17,20	CD154	73,78	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY access|nmod|cells antigens|nsubj|access antigens|nmod|expression expression|compound|END_ENTITY	Direct access to CD4 + T cells specific for defined antigens according to CD154 expression .
16670307	0	CD4	0,3	CD154	77,82	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY induction|nsubj|cell induction|advcl|independent independent|nsubj|blockade blockade|compound|END_ENTITY	CD4 + T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent .
17406204	0	CD4	43,46	CD154	68,73	CD4	CD154	920	959	Gene	Gene	responses|compound|START_ENTITY detect|dobj|responses detect|nmod|expression expression|compound|END_ENTITY	Live-cell assay to detect antigen-specific CD4 + T-cell responses by CD154 expression .
18383039	0	CD4	11,14	CD154	92,97	CD4	CD154	920	473802(Tax:9598)	Gene	Gene	cells|compound|START_ENTITY insensitive|nsubj|cells insensitive|xcomp|HIV-1 HIV-1|dobj|inhibition inhibition|nmod|up-regulation up-regulation|compound|END_ENTITY	Chimpanzee CD4 + T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation .
18606661	0	CD4	17,20	CD154	29,34	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY help|nsubj|role help|nmod|activation activation|nummod|END_ENTITY	Critical role of CD4 help in CD154 blockade-resistant memory CD8 T cell activation and allograft rejection in sensitized recipients .
18785645	0	CD4	107,110	CD154	87,92	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	The influence of different stimulation conditions on the assessment of antigen-induced CD154 expression on CD4 + T cells .
19572319	0	CD4	58,61	CD154	43,48	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|nmod|regulation regulation|nmod|END_ENTITY	In vivo post-transcriptional regulation of CD154 in mouse CD4 + T cells .
20506525	0	CD4	33,36	CD154	101,106	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY CD154|nmod|cells expression|nmod|CD154 increased|nsubj|expression increased|nmod|transcription transcription|compound|END_ENTITY	Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription , increased nuclear factor of activated T cell activity , and glomerulonephritis .
20506525	0	CD4	33,36	CD154	24,29	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription , increased nuclear factor of activated T cell activity , and glomerulonephritis .
20713889	0	CD4	55,58	CD154	151,156	CD4	CD154	920	959	Gene	Gene	epitopes|compound|START_ENTITY carrying|dobj|epitopes splenocytes|acl|carrying confer|nsubj|splenocytes confer|dep|Y Y|advcl|inhibiting inhibiting|dobj|upregulation upregulation|compound|END_ENTITY	Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation .
21496498	0	CD4	56,59	CD154	35,40	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells induction|nmod|subset induction|nmod|END_ENTITY	Stimulation-dependent induction of CD154 on a subset of CD4 + FoxP3 + T-regulatory cells .
21692946	0	CD4	51,54	CD154	0,5	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY stimulation|nmod|cells marker|nmod|stimulation END_ENTITY|appos|marker	CD154 , a marker of antigen-specific stimulation of CD4 T cells , is associated with response to treatment in patients with chronic HCV_infection .
22689014	0	CD4	42,45	CD154	33,38	CD4	CD154	920	959	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Inhibition of activation induced CD154 on CD4 + CD25 - cells : a valid surrogate for human Treg suppressor function .
23071696	0	CD4	28,31	CD154	0,5	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells signaling|compound|END_ENTITY	CD154 and IL-2 signaling of CD4 + T cells play a critical role in multiple phases of CD8 + CTL responses following adenovirus vaccination .
24500400	0	CD4	41,44	CD154	15,20	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24500400	0	CD4	41,44	CD154	78,83	CD4	CD154	920	959	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells binding|nsubj|expression binding|nmod|promoter promoter|compound|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24777309	0	CD4	7,10	CD154	0,5	CD4	CD154	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	dependence|compound|START_ENTITY dependence|compound|END_ENTITY	CD154 + CD4 + T-cell dependence for effective memory influenza virus-specific CD8 + T-cell responses .
9691083	0	CD4	0,3	CD154	80,85	CD4	CD154	920	959	Gene	Gene	T|compound|START_ENTITY T|acl:relcl|tolerized tolerized|nmod|antibody antibody|amod|ligand ligand|dep|CD40L CD40L|dep|END_ENTITY	CD4 -LRB- + -RRB- T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand -LRB- CD40L : CD154 -RRB- antibody lose their graft-versus-host_disease lethality capacity but retain nominal antigen responses .
9826442	0	CD4	67,70	CD154	15,20	CD4	CD154	920	959	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|plays plays|nsubj|TNF-alpha TNF-alpha|appos|END_ENTITY	TNF-alpha , not CD154 -LRB- CD40L -RRB- , plays a major role in SEB-dependent , CD4 -LRB- + -RRB- T cell-induced endothelial cell activation in vitro .
10651077	0	CD4	10,13	CD16	14,18	CD4	CD16	920	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased CD4 + CD16 + and CD4 + CD56 + T cell subsets in Beh et 's disease .
11340249	0	CD4	13,16	CD16	17,21	CD4	CD16	920	2214	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Expansion of CD4 + CD16 + blood monocytes in patients with chronic_renal_failure undergoing dialysis : possible involvement of macrophage_colony-stimulating_factor .
11717198	0	CD4	125,128	CD16	0,4	CD4	CD16	920	2214	Gene	Gene	T|compound|START_ENTITY stimulate|dobj|T abilities|acl|stimulate vitro|nmod|abilities cells|amod|vitro differentiate|nmod|cells +|parataxis|differentiate +|compound|END_ENTITY	CD16 + and CD16 - human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4 + T cells .
1387727	0	CD4	45,48	CD16	57,61	CD4	CD16	920	2214	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
14616964	0	CD4	112,115	CD16	39,43	CD4	CD16	920	2214	Gene	Gene	phenotypes|nummod|START_ENTITY association|nmod|phenotypes analysis|dep|association analysis|nmod|T-cell T-cell|compound|END_ENTITY	TCR Vbeta repertoire analysis in CD56 + CD16 -LRB- dim / - -RRB- T-cell large granular lymphocyte leukaemia : association with CD4 single and CD4/CD8 double positive phenotypes .
1828937	0	CD4	40,43	CD16	97,101	CD4	CD16	920	2214	Gene	Gene	mycosis_fungoides|compound|START_ENTITY skin_lesions|nmod|mycosis_fungoides cells|nmod|skin_lesions cells|acl:relcl|lack lack|dobj|CD57 CD57|appos|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
21227406	0	CD4	105,108	CD16	43,47	CD4	CD16	920	2214	Gene	Gene	T|compound|START_ENTITY IL-10|nmod|T cells|amod|IL-10 production|nmod|cells monocytes|nmod|production maintains|nmod|monocytes maintains|dobj|expression expression|nmod|END_ENTITY	Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human na ve CD4 + T cells .
2346908	0	CD4	108,111	CD16	120,124	CD4	CD16	920	2214	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|+ +|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
17218942	0	CD4	33,36	CD160	26,31	CD4	CD160	920	11126	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of a novel CD160 + CD4 + T-lymphocyte subset in the skin : a possible role for CD160 in skin_inflammation .
17218942	0	CD4	33,36	CD160	91,96	CD4	CD160	920	11126	Gene	Gene	subset|compound|START_ENTITY Identification|nmod|subset Identification|dep|role role|nmod|END_ENTITY	Identification of a novel CD160 + CD4 + T-lymphocyte subset in the skin : a possible role for CD160 in skin_inflammation .
18193050	0	CD4	35,38	CD160	0,5	CD4	CD160	920	11126	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells inhibits|dobj|activation inhibits|nsubj|END_ENTITY	CD160 inhibits activation of human CD4 + T cells through interaction with herpesvirus entry mediator .
25044837	0	CD4	87,90	CD160	36,41	CD4	CD160	920	11126	Gene	Gene	subset|compound|START_ENTITY delineate|dobj|subset contributes|xcomp|delineate contributes|nsubj|expression expression|nmod|END_ENTITY	Membrane expression of NK receptors CD160 and CD158k contributes to delineate a unique CD4 + T-lymphocyte subset in normal and mycosis_fungoides skin .
25179432	0	CD4	33,36	CD160	0,5	CD4	CD160	920	11126	Gene	Gene	responses|compound|START_ENTITY isoforms|nmod|responses isoforms|compound|END_ENTITY	CD160 isoforms and regulation of CD4 and CD8 T-cell responses .
16365412	0	CD4	55,58	CD161	14,19	CD4	CD161	920	3820	Gene	Gene	subsets|nmod|START_ENTITY defines|dobj|subsets defines|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD161 -LRB- NKR-P1A -RRB- defines subsets of human CD4 and CD8 T cells with different functional activities .
17145807	0	CD4	23,26	CD161	45,50	CD4	CD161	920	3820	Gene	Gene	frequency|nmod|START_ENTITY +|nsubj|frequency +|dobj|cells cells|acl|expressing expressing|dobj|END_ENTITY	Increased frequency of CD4 + cells expressing CD161 in cancer patients .
18663128	0	CD4	60,63	CD161	54,59	CD4	CD161	920	3820	Gene	Gene	precursor|compound|START_ENTITY precursor|compound|END_ENTITY	Human interleukin 17-producing cells originate from a CD161 + CD4 + T cell precursor .
22084439	0	CD4	93,96	CD161	86,91	CD4	CD161	920	3820	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161 + CD4 + regulatory T cells .
22100877	0	CD4	62,65	CD161	30,35	CD4	CD161	920	3820	Gene	Gene	CD8|compound|START_ENTITY +|dep|CD8 cells|appos|+ END_ENTITY|dep|cells	Depletion of pro-inflammatory CD161 -LRB- + -RRB- double negative -LRB- CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- -RRB- T cells in AIDS patients is ameliorated by expansion of the y T cell population .
23146786	0	CD4	15,18	CD161	19,24	CD4	CD161	920	3820	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of CD4 + CD161 + CD196 + and CD4 + IL-17 + Th17 cells in the peripheral blood of young patients with Hashimoto 's _ thyroiditis and Graves ' _ disease -RSB- .
23257766	0	CD4	0,3	CD161	4,9	CD4	CD161	920	3820	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD161 + T lymphocytes infiltrate Crohn 's _ disease-associated_perianal_fistulas and are reduced by anti-TNF-a local therapy .
24223933	0	CD4	12,15	CD161	16,21	CD4	CD161	920	3820	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Circulating CD4 + CD161 + T lymphocytes are increased in seropositive arthralgia patients but decreased in patients with newly diagnosed rheumatoid_arthritis .
25960619	0	CD4	15,18	CD161	19,24	CD4	CD161	920	3820	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Percentages of CD4 + CD161 + and CD4-CD8-CD161 + T Cells in the Synovial Fluid Are Correlated with Disease Activity in Rheumatoid_Arthritis .
23017670	0	CD4	0,3	CD178	24,29	CD4	CD178	920	356	Gene	Gene	CD25|compound|START_ENTITY CD25|acl:relcl|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
16339524	0	CD4	57,60	CD18	0,4	CD4	CD18	12504(Tax:10090)	16414(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells required|nmod|development required|nsubjpass|END_ENTITY	CD18 is required for optimal development and function of CD4 + CD25 + T regulatory cells .
23146786	0	CD4	15,18	CD196	25,30	CD4	CD196	920	1235	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of CD4 + CD161 + CD196 + and CD4 + IL-17 + Th17 cells in the peripheral blood of young patients with Hashimoto 's _ thyroiditis and Graves ' _ disease -RSB- .
9551963	0	CD4	189,192	CD1a	81,85	CD4	CD1a	920	909	Gene	Gene	T|compound|START_ENTITY toxin-1|nmod|T cells|amod|toxin-1 anergy|nmod|cells susceptible|xcomp|anergy susceptible|nsubj|maturation maturation|acl|migrating migrating|dobj|cells cells|dep|END_ENTITY	Post-thymic maturation of migrating human thymic single-positive T cells : thymic CD1a - CD4 + T cells are more susceptible to anergy induction by toxic_shock_syndrome toxin-1 than cord blood CD4 + T cells .
9551963	0	CD4	87,90	CD1a	81,85	CD4	CD1a	920	909	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Post-thymic maturation of migrating human thymic single-positive T cells : thymic CD1a - CD4 + T cells are more susceptible to anergy induction by toxic_shock_syndrome toxin-1 than cord blood CD4 + T cells .
11174380	0	CD4	5,8	CD2	0,3	CD4	CD2	920	914	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	CD2 - CD4 + CD56 + hematodermic/hematolymphoid _ malignancy .
11801645	0	CD4	35,38	CD2	0,3	CD4	CD2	12504(Tax:10090)	12481(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells facilitates|dobj|differentiation facilitates|nsubj|END_ENTITY	CD2 facilitates differentiation of CD4 Th cells without affecting Th1/Th2 polarization .
1354232	0	CD4	135,138	CD2	0,3	CD4	CD2	920	914	Gene	Gene	clone|compound|START_ENTITY alkyl-arachidonoyl-glycerophosphocholine|nmod|clone stimulates|nmod|alkyl-arachidonoyl-glycerophosphocholine stimulates|nsubj|triggering triggering|compound|END_ENTITY	CD2 triggering stimulates the formation of platelet-activating factor-acether from alkyl-arachidonoyl-glycerophosphocholine in a human CD4 + T lymphocyte clone .
15748810	0	CD4	56,59	CD2	109,112	CD4	CD2	920	914	Gene	Gene	T|compound|START_ENTITY gingipains|nmod|T Binding|dep|gingipains Binding|nsubj|cells cells|acl:relcl|affect affect|nsubj|END_ENTITY	Binding of Porphyromonas_gingivalis gingipains to human CD4 -LRB- + -RRB- T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expression .
17904553	0	CD4	36,39	CD2	29,32	CD4	CD2	920	914	Gene	Gene	T-cell|compound|START_ENTITY END_ENTITY|nmod|T-cell	Leishmania_donovani : role of CD2 on CD4 + T-cell function in Visceral_Leishmaniasis .
18649854	0	CD4	137,140	CD2	149,152	CD4	CD2	920	914	Gene	Gene	appearance|nmod|START_ENTITY factors|nmod|appearance factors|appos|cells cells|nummod|+ +|compound|END_ENTITY	Decreased maturation of T-cell populations in the healthy elderly : Influence of nutritional factors on the appearance of double negative CD4 - , CD8 - , CD2 + cells .
21300823	0	CD4	54,57	CD2	0,3	CD4	CD2	920	914	Gene	Gene	CD25|compound|START_ENTITY reveals|nmod|CD25 reveals|nsubj|costimulation costimulation|compound|END_ENTITY	CD2 costimulation reveals defective activity by human CD4 + CD25 -LRB- hi -RRB- regulatory cells in patients with multiple_sclerosis .
21767541	0	CD4	20,23	CD2	84,87	CD4	CD2	920	914	Gene	Gene	CD8|compound|START_ENTITY induction|nmod|CD8 +|nsubj|induction +|advcl|coculturing coculturing|dobj|cells cells|nummod|END_ENTITY	Marked induction of CD4 + CD8 + T cells with multifunctional properties by coculturing CD2 + cells with xenogeneic stromal cells .
2346908	0	CD4	108,111	CD2	96,99	CD4	CD2	920	914	Gene	Gene	-|compound|START_ENTITY +|appos|- +|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
23760244	0	CD4	78,81	CD2	15,18	CD4	CD2	920	914	Gene	Gene	T|compound|START_ENTITY cells|nsubj|T identify|xcomp|cells identify|nsubj|levels levels|nmod|expression expression|compound|END_ENTITY	High levels of CD2 expression identify HIV-1 latently infected resting memory CD4 + T cells in virally suppressed subjects .
2458944	0	CD4	0,3	CD2	58,61	CD4	CD2	920	914	Gene	Gene	cells|compound|START_ENTITY activated|nsubjpass|cells activated|nmod|pathway pathway|compound|END_ENTITY	CD4 + CD45R + cells are preferentially activated through the CD2 pathway .
2783435	0	CD4	14,17	CD2	101,104	CD4	CD2	920	914	Gene	Gene	Regulation|nmod|START_ENTITY surface|nsubj|Regulation surface|advcl|triggering triggering|nmod|END_ENTITY	Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and the CD3-T cell receptor .
2783659	0	CD4	110,113	CD2	83,86	CD4	CD2	920	914	Gene	Gene	lymphoma|appos|START_ENTITY lymphoma|nmod|phenotype phenotype|nmod|+ +|compound|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
7589092	0	CD4	39,42	CD2	19,22	CD4	CD2	920	914	Gene	Gene	cells|nummod|START_ENTITY rescues|dobj|cells rescues|nsubj|Ligation Ligation|nmod|END_ENTITY	Ligation of either CD2 or CD28 rescues CD4 + T cells from HIV-gp120-induced apoptosis .
7687614	0	CD4	81,84	CD2	77,80	CD4	CD2	12504(Tax:10090)	12481(Tax:10090)	Gene	Gene	precursor|compound|START_ENTITY precursor|compound|END_ENTITY	CD2-CD4-CD8 - lymph node T lymphocytes in MRL lpr/lpr mice are derived from a CD2 + CD4 + CD8 + thymic precursor .
7842346	0	CD4	10,13	CD2	5,8	CD4	CD2	920	914	Gene	Gene	expression|compound|START_ENTITY lymphocytes|nsubj|expression lymphocytes|advcl|-LSB- -LSB-|dobj|END_ENTITY	-LSB- The CD2 , CD4 and CD8 mRNA expression of T lymphocytes in patients with acromegaly and hyperprolactinemia -RSB- .
8095456	0	CD4	80,83	CD2	4,7	CD4	CD2	920	914	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells induce|dobj|proliferation induce|nsubj|END_ENTITY	The CD2 and CD28 adhesion molecules induce long-term autocrine proliferation of CD4 + T cells .
9028954	0	CD4	70,73	CD2	0,3	CD4	CD2	12504(Tax:10090)	12481(Tax:10090)	Gene	Gene	selection|nmod|START_ENTITY regulates|dobj|selection regulates|nsubj|END_ENTITY	CD2 regulates the positive selection and function of antigen-specific CD4 - CD8 + T cells .
9763034	0	CD4	27,30	CD2	22,25	CD4	CD2	920	914	Gene	Gene	CD56|compound|START_ENTITY END_ENTITY|dep|CD56	A cutaneous agranular CD2 - CD4 + CD56 + `` lymphoma '' : report of two cases and review of the literature .
9767458	0	CD4	49,52	CD2	149,152	CD4	CD2	920	914	Gene	Gene	T|compound|START_ENTITY migration|nmod|T induction|nmod|migration lymphocytes|nsubj|induction lymphocytes|nmod|matrices matrices|acl|mediated mediated|advcl|signalling signalling|nmod|END_ENTITY	Direct and rapid induction of migration in human CD4 + T lymphocytes within three-dimensional collagen matrices mediated by signalling via CD3 and/or CD2 .
9790118	0	CD4	6,9	CD2	0,3	CD4	CD2	920	914	Gene	Gene	+|compound|START_ENTITY -|appos|+ -|compound|END_ENTITY	CD2 - , CD4 + , CD56 + agranular natural killer cell lymphoma of the skin .
9862369	0	CD4	16,19	CD2	53,56	CD4	CD2	12504(Tax:10090)	12481(Tax:10090)	Gene	Gene	responses|nummod|START_ENTITY induced|nsubj|responses induced|nmod|CD48 CD48|compound|END_ENTITY	Enhanced murine CD4 + T cell responses induced by the CD2 ligand CD48 .
21750737	0	CD4	49,52	CD226	32,37	CD4	CD226	12504(Tax:10090)	225825(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	RTL551 treatment of EAE reduces CD226 and T-bet + CD4 T cells in periphery and prevents infiltration of T-bet + IL-17 , IFN-y producing T cells into CNS .
12006207	0	CD4	24,27	CD23	87,91	CD4	CD23	920	2208	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|CLL CLL|compound|END_ENTITY	Selection of autologous CD4 + T-cells for adoptive T-cell substitution in patients with CD23 + B-cell CLL .
1673432	0	CD4	76,79	CD23	48,52	CD4	CD23	920	2208	Gene	Gene	bone|compound|START_ENTITY growth|nmod|bone END_ENTITY|nmod|growth	Synergistic effect of interleukin_1 and soluble CD23 on the growth of human CD4 + bone marrow-derived T cells .
7910139	0	CD4	25,28	CD23	17,21	CD4	CD23	920	2208	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	Allergen-induced CD23 on CD4 + T lymphocytes and CD21 on B lymphocytes in patients with allergic_asthma : evidence and regulation .
9420139	0	CD4	127,130	CD23	132,136	CD4	CD23	920	2208	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
10200133	0	CD4	47,50	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	lymphocytes|nummod|START_ENTITY Expression|nmod|lymphocytes Expression|nmod|receptor receptor|appos|END_ENTITY	Expression of interleukin-2 receptor , CD25 , on CD4 lymphocytes in response_to_varicella-zoster_virus antigen among patients with malignancies immunized with live attenuated varicella vaccine .
10553041	0	CD4	45,48	CD25	40,44	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Induction of tumor immunity by removing CD25 + CD4 + T cells : a common basis between tumor immunity and autoimmunity .
10605010	0	CD4	32,35	CD25	36,40	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppressor effector function of CD4 + CD25 + immunoregulatory T cells is antigen nonspecific .
10795741	0	CD4	62,65	CD25	66,70	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	B7/CD28 costimulation is essential for the homeostasis of the CD4 + CD25 + immunoregulatory T cells that control autoimmune diabetes .
10975823	0	CD4	21,24	CD25	0,4	CD4	CD25	24932(Tax:10116)	3559	Gene	Gene	thymocytes|nummod|START_ENTITY marker|nmod|thymocytes marker|nsubj|END_ENTITY	CD25 is a marker for CD4 + thymocytes that prevent autoimmune_diabetes in rats , but peripheral T cells with this function are found in both CD25 + and CD25 - subpopulations .
11182148	0	CD4	39,42	CD25	103,107	CD4	CD25	404704(Tax:9823)	396814(Tax:9823)	Gene	Gene	characterization|nmod|START_ENTITY characterization|parataxis|lymphoblastoid lymphoblastoid|nmod|phenotype phenotype|compound|END_ENTITY	Functional characterization of a swine CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- double positive lymphoblastoid T-cell line with a CD25 -LRB- + -RRB- / CD45RA -LRB- - -RRB- phenotype generated in vitro with interleukin-2 .
11207250	0	CD4	56,59	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells regulate|dobj|expansion +|ccomp|regulate +|nsubj|CD4 CD4|compound|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11390462	0	CD4	89,92	CD25	93,97	CD4	CD25	920	3559	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Tolerance to cyclosporin_A-induced autologous graft-versus-host disease is mediated by a CD4 + CD25 + subset of recent thymic emigrants .
11466326	0	CD4	51,54	CD25	55,59	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : control of CD8 + T cell activation by CD4 + CD25 + immunoregulatory cells .
11488983	0	CD4	28,31	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|induction induction|nmod|END_ENTITY	In vitro induction of CD25 + CD4 + regulatory T cells by the neuropeptide alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- .
11564442	0	CD4	19,22	CD25	42,46	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	Natural regulatory CD4 T cells expressing CD25 .
11696203	0	CD4	52,55	CD25	60,64	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	TCRbeta|compound|START_ENTITY TCRbeta|compound|END_ENTITY	CD8 + T cells induce medullary thymic epithelium and CD4 + CD8 + CD25 + TCRbeta - thymocytes in SCID mice .
11722621	0	CD4	42,45	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immunologic tolerance maintained by CD25 + CD4 + regulatory T cells : their common role in controlling autoimmunity , tumor immunity , and transplantation tolerance .
11722623	0	CD4	32,35	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Control of T-cell activation by CD4 + CD25 + suppressor T cells .
11890298	0	CD4	101,104	CD25	105,109	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased total numbers of peripheral blood lymphocytes with elevated percentages of CD4 + CD45RO + and CD4 + CD25 + of T-helper cells in non-segmental_vitiligo .
11981815	0	CD4	38,41	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY hyperinflammation|nsubj|T suppress|xcomp|hyperinflammation +|ccomp|suppress +|nsubj|CD4 CD4|compound|END_ENTITY	CD25 + CD4 + regulatory T cells suppress CD4 + T cell-mediated pulmonary hyperinflammation driven by Pneumocystis_carinii in immunodeficient mice .
11981815	7	CD4	1065,1068	CD25	1058,1062	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	In contrast , transfer of CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- cells did not induce lethal pneumonia and prevented the development of the disease induced by CD25 -LRB- - -RRB- CD4 -LRB- + -RRB- cells .
12000861	0	CD4	3,6	CD25	8,12	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Do CD4 + CD25 + immunoregulatory T cells hinder tumor immunotherapy ?
12000862	0	CD4	13,16	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory cells augments the generation of specific immune T cells in tumor-draining lymph_nodes .
12028564	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12028564	0	CD4	0,3	CD25	75,79	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|ccomp|suppress suppress|dobj|proliferation proliferation|nmod|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12028564	0	CD4	71,74	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY proliferation|nmod|CD25 suppress|dobj|proliferation lymphocytes|ccomp|suppress lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12047748	0	CD4	32,35	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of human CD25 + CD4 + T cells in thymus , cord and adult blood .
12055202	0	CD4	27,30	CD25	31,35	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : depletion of CD4 + CD25 + regulatory T cells is necessary , but not sufficient , for induction of organ-specific autoimmune_disease .
12060392	0	CD4	59,62	CD25	66,70	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Transient CD44 variant isoform expression and reduction in CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- regulatory T cells in C3H/HeJ mice with alopecia areata .
12087082	0	CD4	91,94	CD25	48,52	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY decreased|nmod|+ decreased|nsubjpass|Expression Expression|nmod|interleukin-2_receptor_alpha interleukin-2_receptor_alpha|appos|END_ENTITY	Expression of the interleukin-2_receptor_alpha -LRB- CD25 -RRB- is selectively decreased on decidual CD4 + and CD8 + T lymphocytes in normal pregnancies .
12093005	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + suppressor T cells : more questions than answers .
12119350	0	CD4	98,101	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY activity|nmod|T cells|nsubj|activity convey|xcomp|cells END_ENTITY|acl:relcl|convey	Infectious tolerance : human CD25 -LRB- + -RRB- regulatory T cells convey suppressor activity to conventional CD4 -LRB- + -RRB- T helper cells .
12163566	0	CD4	57,60	CD25	63,67	CD4	CD25	920	3559	Gene	Gene	suppression|nmod|START_ENTITY Phenotype|nmod|suppression END_ENTITY|nsubj|Phenotype	Phenotype , localization , and mechanism of suppression of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- human thymocytes .
12193715	0	CD4	21,24	CD25	25,29	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
12200381	0	CD4	126,129	CD25	133,137	CD4	CD25	920	3559	Gene	Gene	subset|nmod|START_ENTITY characterization|nmod|subset effects|dep|characterization effects|parataxis|T T|nsubj|END_ENTITY	Long-term effects of intermittent interleukin_2 therapy in patients with HIV_infection : characterization of a novel subset of CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- T cells .
12218142	0	CD4	167,170	CD25	171,175	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The early IL-4 response to Leishmania_major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 + CD25 + T cells .
12234995	0	CD4	65,68	CD25	70,74	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY Inhibition|nmod|+ Inhibition|parataxis|mediated mediated|nsubjpass|cells cells|nummod|END_ENTITY	Inhibition of cytolytic T lymphocyte proliferation by autologous CD4 + / CD25 + regulatory T cells in a colorectal_carcinoma patient is mediated by transforming_growth_factor-beta .
12406391	0	CD4	12,15	CD25	16,20	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The role of CD4 + CD25 + immunoregulatory T cells in the induction of autoimmune_gastritis .
12421913	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : CD4 + CD25 + alloantigen-specific immunoregulatory cells that can prevent CD8 + T cell-mediated graft rejection : implications for anti-CD154 immunotherapy .
12438424	0	CD4	11,14	CD25	6,10	CD4	CD25	920	3559	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Human CD25 + CD4 + T suppressor cell clones produce transforming_growth_factor_beta , but not interleukin_10 , and are distinct from type 1 T regulatory cells .
12444136	0	CD4	18,21	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	B7/CD28-dependent CD4 + CD25 + regulatory T cells are essential components of the memory-protective immunity to Candida_albicans .
12466842	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control Leishmania_major persistence and immunity .
12496410	0	CD4	23,26	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY mediate|nsubj|cells immunoregulatory|ccomp|mediate immunoregulatory|nsubj|+ +|compound|END_ENTITY	CD25 + immunoregulatory CD4 T cells mediate acquired central transplantation tolerance .
12515818	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD25 + T -LRB- R -RRB- cells suppress innate immune pathology through cytokine-dependent mechanisms .
12547727	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + regulatory T lymphocytes inhibit microbially induced colon_cancer in Rag2-deficient mice .
12594277	0	CD4	82,85	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	colitis|nummod|START_ENTITY suppress|dobj|colitis express|ccomp|suppress cells|acl:relcl|express END_ENTITY|dep|cells	CD4 + CD25 - T cells that express latency-associated_peptide on the surface suppress CD4 + CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism .
12612578	0	CD4	47,50	CD25	51,55	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells .
12612581	0	CD4	33,36	CD25	37,41	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	An essential role for Scurfin in CD4 + CD25 + T regulatory cells .
12645292	0	CD4	1,4	CD25	7,11	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|appos|T-lymphocytes T-lymphocytes|nummod|+ +|compound|END_ENTITY	-LSB- CD4 + , CD25 + regulatory T-lymphocytes : current concepts and therapeutic potential -RSB- .
12651220	0	CD4	30,33	CD25	34,38	CD4	CD25	920	3559	Gene	Gene	immunosuppression|compound|START_ENTITY immunosuppression|compound|END_ENTITY	TGF-beta : the missing link in CD4 + CD25 + regulatory T cell-mediated immunosuppression .
12663682	0	CD4	18,21	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Antigen-specific , CD4 + CD25 + regulatory T cell clones induced in Peyer 's patches .
12718754	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + immunoregulatory T cells may not be involved in controlling autoimmune_arthritis .
12731049	0	CD4	18,21	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Idiotype-specific CD4 + CD25 + T suppressor cells prevent , by limiting antibody diversity , the occurrence of anti-dextran antibodies crossreacting with histone H3 .
12734345	0	CD4	118,121	CD25	122,126	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Superantigen-induced regulatory T cells display different suppressive functions in the presence or absence of natural CD4 + CD25 + regulatory T cells in vivo .
12743364	0	CD4	122,125	CD25	94,98	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25 - and CTLA-4-expressing CD4 + T cells .
12750357	0	CD4	123,126	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY transfer|nmod|cells cells|acl:relcl|transfer END_ENTITY|dep|cells	Nasal tolerance induces antigen-specific CD4 + CD25 - regulatory T cells that can transfer their regulatory capacity to naive CD4 + T cells .
12759427	0	CD4	10,13	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial_hyperreactivity .
12761268	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients .
12810075	0	CD4	86,89	CD25	53,57	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY subsets|nmod|cells expressions|dep|subsets expressions|nmod|gene gene|nmod|END_ENTITY	Differential expressions of heme_oxygenase-1 gene in CD25 - and CD25 + subsets of human CD4 + T cells .
12810075	0	CD4	86,89	CD25	63,67	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY subsets|nmod|cells subsets|nummod|END_ENTITY	Differential expressions of heme_oxygenase-1 gene in CD25 - and CD25 + subsets of human CD4 + T cells .
12847237	0	CD4	67,70	CD25	51,55	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY Regulation|dep|+ Regulation|nmod|inflammatory_bowel_disease inflammatory_bowel_disease|nmod|+ +|compound|END_ENTITY	Regulation of murine inflammatory_bowel_disease by CD25 + and CD25 - CD4 + glucocorticoid-induced TNF receptor family-related gene + regulatory T cells .
12855551	0	CD4	7,10	CD25	11,15	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Innate CD4 + CD25 + regulatory T cells are required for oral tolerance and inhibition of CD8 + T cells mediating skin_inflammation .
12874259	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo .
12893750	0	CD4	73,76	CD25	77,81	CD4	CD25	920	3559	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Human CD8 + CD25 + thymocytes share phenotypic and functional features with CD4 + CD25 + regulatory thymocytes .
12893754	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells inhibit immune-mediated transgene rejection .
12907445	0	CD4	25,28	CD25	0,4	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nummod|END_ENTITY	CD25 expression on donor CD4 + or CD8 + T cells is associated with an increased risk for graft-versus-host_disease after HLA-identical stem cell transplantation in humans .
12923427	0	CD4	80,83	CD25	75,79	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Pretransplant blood transfusion without additional immunotherapy generates CD25 + CD4 + regulatory T cells : a potential explanation for the blood-transfusion effect .
12928371	0	CD4	41,44	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY populations|compound|END_ENTITY	Systemic overexpression of IL-10 induces CD4 + CD25 + cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion .
12941137	0	CD4	32,35	CD25	0,4	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	CD25 + , interleukin-10-producing CD4 + T cells are required for suppressor cell production and immune privilege in the anterior chamber of the eye .
12947044	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T cells responding to serologically defined autoantigens suppress antitumor immune responses .
12949259	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells control anti-islet CD8 + T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes .
12967782	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	mediate|compound|START_ENTITY mediate|compound|END_ENTITY	CD4 + CD25 + regulatory T cells mediate acquired transplant tolerance .
14500627	0	CD4	54,57	CD25	58,62	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : CD28 controls peripheral homeostasis of CD4 + CD25 + regulatory T cells .
14500643	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + and CD4 + CD25 - T cells act respectively as inducer and effector T suppressor cells in superantigen-induced tolerance .
14515359	0	CD4	27,30	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional assay for human CD4 + CD25 + Treg cells reveals an age-dependent loss of suppressive activity .
14519757	0	CD4	92,95	CD25	97,101	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4 + CD25 + and CD8 + regulatory T cell subsets .
14522933	0	CD4	0,3	CD25	6,10	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	require|nsubj|START_ENTITY require|nsubj|lymphocytes lymphocytes|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory lymphocytes require interleukin_10 to interrupt colon_carcinogenesis in mice .
14568934	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD4 + CD25 + T cells lyse antigen-presenting B cells by Fas-Fas ligand interaction in an epitope-specific manner .
14609209	0	CD4	40,43	CD25	35,39	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Thymic generation and selection of CD25 + CD4 + regulatory T cells : implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance .
14609210	0	CD4	32,35	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Control of T cell activation by CD4 + CD25 + suppressor T cells .
14609212	0	CD4	62,65	CD25	66,70	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The role of CD28 and CTLA4 in the function and homeostasis of CD4 + CD25 + regulatory T cells .
14609213	0	CD4	0,3	CD25	83,87	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY express|nsubj|CD25 express|dobj|levels levels|nmod|vivo vivo|compound|END_ENTITY	CD4 + CD25 + regulatory cells from human peripheral blood express very high levels of CD25 ex vivo .
14609215	0	CD4	54,57	CD25	58,62	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Type 1 T regulatory cells and their relationship with CD4 + CD25 + T regulatory cells .
14632657	1	CD4	60,63	CD25	65,69	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations in CD4 + CD25 + T regulatory cell phenotype and T-cell receptor Vbeta repertoire .
14676299	0	CD4	25,28	CD25	56,60	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Conversion|nmod|CD25 Conversion|dep|cells cells|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	CD4	52,55	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY cells|nmod|CD25 Conversion|dep|cells Conversion|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14678036	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD4 + CD25 + CD62 + T-regulatory cell subset has optimal suppressive and proliferative potential .
14679076	0	CD4	53,56	CD25	57,61	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Difference in gene expression profiles between human CD4 + CD25 + and CD4 + CD25 - T cells .
14699080	0	CD4	24,27	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Impaired development of CD4 + CD25 + regulatory T cells in the absence of STAT1 : increased susceptibility to autoimmune_disease .
14707048	0	CD4	37,40	CD25	41,45	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD7 and CD28 are required for murine CD4 + CD25 + regulatory T cell homeostasis and prevention of thyroiditis .
14707053	0	CD4	55,58	CD25	59,63	CD4	CD25	920	3559	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	TGF-beta_1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice .
14707064	0	CD4	25,28	CD25	20,24	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Alloantigen-induced CD25 + CD4 + regulatory T cells can develop in vivo from CD25-CD4 + precursors in a thymus-independent process .
14734610	0	CD4	90,93	CD25	85,89	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-10 is involved in the suppression of experimental_autoimmune_encephalomyelitis by CD25 + CD4 + regulatory T cells .
14734622	0	CD4	42,45	CD25	46,50	CD4	CD25	24932(Tax:10116)	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic characterization of regulatory CD4 + CD25 + T cells in rats .
14744995	0	CD4	80,83	CD25	85,89	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Massive thymic deletion results in systemic autoimmunity through elimination of CD4 + CD25 + T regulatory cells .
14768041	0	CD4	45,48	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Activation requirements for the induction of CD4 + CD25 + T cell suppressor function .
14871297	0	CD4	10,13	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|nummod|END_ENTITY	Decreased CD4 + CD25 + T cells in peripheral blood of patients with systemic_lupus_erythematosus .
14963140	0	CD4	6,9	CD25	11,15	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens .
14979928	0	CD4	34,37	CD25	29,33	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A paragon of self-tolerance : CD25 + CD4 + regulatory T cells and the control of immune responses .
14991599	0	CD4	139,142	CD25	143,147	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991599	0	CD4	139,142	CD25	58,62	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY counter-regulated|nmod|cells cells|acl:relcl|counter-regulated Demonstration|dep|cells Demonstration|nmod|reactivity reactivity|nmod|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991599	0	CD4	54,57	CD25	143,147	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY reactivity|nmod|CD25 Demonstration|nmod|reactivity Demonstration|dep|cells cells|acl:relcl|counter-regulated counter-regulated|nmod|cells cells|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991600	0	CD4	31,34	CD25	25,29	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	MHC class II-independent CD25 + CD4 + CD8alpha beta + alpha beta T cells attenuate CD4 + T cell-induced transfer colitis .
14991600	0	CD4	80,83	CD25	25,29	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	MHC class II-independent CD25 + CD4 + CD8alpha beta + alpha beta T cells attenuate CD4 + T cell-induced transfer colitis .
14991616	0	CD4	32,35	CD25	36,40	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Differential response of murine CD4 + CD25 + and CD4 + CD25 - T cells to dexamethasone-induced cell death .
15016653	0	CD4	86,89	CD25	90,94	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15021844	0	CD4	11,14	CD25	15,19	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + T cells in the peripheral blood of lung transplant recipients : correlation with transplant outcome .
15024182	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3669	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Circulating CD4 + CD25 + T regulatory cells are not altered in multiple_sclerosis and unaffected by disease-modulating drugs .
15027897	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg : divide and rule ?
15034024	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the severity of viral_immunoinflammatory_lesions .
15036231	0	CD4	20,23	CD25	24,28	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naturally-occurring CD4 + CD25 + immunoregulatory T cells : central players in the arena of peripheral tolerance .
15049785	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CD4 + CD25 + and CD4 + CD25 + T cells in myasthenia_gravis and in relation to thymectomy .
15067041	0	CD4	20,23	CD25	24,28	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : human CD4 + CD25 + T cells restrain the maturation and antigen-presenting function of dendritic cells .
15067051	0	CD4	100,103	CD25	104,108	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Feline_immunodeficiency_virus_infection phenotypically and functionally activates immunosuppressive CD4 + CD25 + T regulatory cells .
15096182	0	CD4	87,90	CD25	81,85	CD4	CD25	920	3559	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Normal human pregnancy is associated with an elevation in the immune suppressive CD25 + CD4 + regulatory T-cell subset .
15100259	0	CD4	20,23	CD25	48,52	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|educate educate|dobj|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15100259	0	CD4	44,47	CD25	24,28	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY educate|dobj|CD25 +|ccomp|educate +|nsubj|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15100684	13	CD4	1819,1822	CD25	1823,1827	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	In contrast , after SEB stimulation , CD4 + CD25 + cells were no longer anergic .
15111929	0	CD4	65,68	CD25	0,4	CD4	CD25	920	3559	Gene	Gene	T-cell|compound|START_ENTITY subsets|nsubj|T-cell subsets|nsubj|distinguishes distinguishes|compound|END_ENTITY	CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 -LRB- OX40 -RRB- T-cell subsets in acute_graft-versus-host_disease .
15119549	0	CD4	16,19	CD25	20,24	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A deficiency of CD4 + CD25 + T cells permits the development of spontaneous_lupus-like_disease in mice , and can be reversed by induction of mucosal tolerance to histone peptide autoantigen .
15136590	0	CD4	144,147	CD25	149,153	CD4	CD25	920	3559	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Increased expression of human T lymphocyte virus type I -LRB- HTLV-I -RRB- Tax11-19 peptide-human histocompatibility leukocyte antigen A * 201 complexes on CD4 + CD25 + T Cells detected by peptide-specific , major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic_disease .
15153463	0	CD4	73,76	CD25	77,81	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Cutting edge : IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function .
15161853	0	CD4	52,55	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|responses responses|nmod|self-antigens self-antigens|nmod|END_ENTITY	Immune responses to retinal self-antigens in CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T-cell-depleted mice .
15184500	0	CD4	6,9	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD25 + CD4 + T cells , expanded with dendritic cells presenting a single autoantigenic peptide , suppress autoimmune diabetes .
15184501	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic_lesion .
15185013	0	CD4	46,49	CD25	50,54	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dendritic_cells reduce number and function of CD4 + CD25 + cells in cytokine-induced killer cells derived from patients with pancreatic_carcinoma .
15187106	0	CD4	96,99	CD25	79,83	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Costimulation via glucocorticoid-induced_TNF_receptor in both conventional and CD25 + regulatory CD4 + T cells .
15240694	0	CD4	14,17	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Resistance to CD4 + CD25 + regulatory T cells and TGF-beta in Cbl-b - / - mice .
15240714	0	CD4	5,8	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15240805	0	CD4	83,86	CD25	87,91	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dopamine , through the extracellular signal-regulated kinase pathway , downregulates CD4 + CD25 + regulatory T-cell activity : implications for neurodegeneration .
15271794	0	CD4	107,110	CD25	53,57	CD4	CD25	920	3559	Gene	Gene	responses|compound|START_ENTITY suppress|dobj|responses cells|acl:relcl|suppress +|dobj|cells +|nsubj|expansion expansion|nmod|END_ENTITY	Human_immunodeficiency virus-driven expansion of CD4 + CD25 + regulatory T cells , which suppress HIV-specific CD4 T-cell responses in HIV-infected patients .
15294932	0	CD4	47,50	CD25	51,55	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	compartment|compound|START_ENTITY compartment|compound|END_ENTITY	Cutting edge : estrogen drives expansion of the CD4 + CD25 + regulatory T cell compartment .
15295006	0	CD4	35,38	CD25	39,43	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Targeted CTLA-4 engagement induces CD4 + CD25 + CTLA-4high T regulatory cells with target -LRB- allo -RRB- antigen specificity .
15298560	0	CD4	96,99	CD25	101,105	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction of T ` regulatory ' cells by standardized house dust mite immunotherapy : an increase in CD4 + CD25 + interleukin-10 + T cells expressing peripheral tissue trafficking markers .
15307180	0	CD4	31,34	CD25	35,39	CD4	CD25	920	3559	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Interleukin-2 is essential for CD4 + CD25 + regulatory T cell function .
15308106	0	CD4	62,65	CD25	56,60	CD4	CD25	920	3559	Gene	Gene	receptors|compound|START_ENTITY receptors|nummod|END_ENTITY	Recognition of the peripheral self by naturally arising CD25 + CD4 + T cell receptors .
15322152	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + cells controlling a pathogenic CD4 response inhibit cytokine differentiation , CXCR-3 expression , and tissue invasion .
15322152	0	CD4	41,44	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	response|compound|START_ENTITY controlling|dobj|response cells|acl|controlling cells|compound|END_ENTITY	CD4 + CD25 + cells controlling a pathogenic CD4 response inhibit cytokine differentiation , CXCR-3 expression , and tissue invasion .
15322168	0	CD4	25,28	CD25	29,33	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional maturation of CD4 + CD25 + CTLA4 + CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens .
15331781	0	CD4	15,18	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dual effect of CD4 + CD25 + regulatory T cells in neurodegeneration : a dialogue with microglia .
15376196	0	CD4	20,23	CD25	24,28	CD4	CD25	920	3669	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of a CD4 + CD25 + T cell subset committed in vivo to suppress antigen-specific T cell responses without additional stimulation .
15383574	0	CD4	99,102	CD25	103,107	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4 + CD25 + regulatory T cells .
15456701	0	CD4	105,108	CD25	109,113	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Blockade of CD86 signaling facilitates a Th2 bias at the maternal-fetal interface and expands peripheral CD4 + CD25 + regulatory T cells to rescue abortion-prone fetuses .
15466453	0	CD4	68,71	CD25	63,67	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Crucial role of FOXP3 in the development and function of human CD25 + CD4 + regulatory T cells .
15470042	0	CD4	7,10	CD25	11,15	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine CD4 + CD25 + regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene .
15470044	0	CD4	138,141	CD25	142,146	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Engagement of glucocorticoid-induced_TNFR_family-related_receptor on effector T cells by its ligand mediates resistance to suppression by CD4 + CD25 + T cells .
15479730	0	CD4	85,88	CD25	80,84	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25 + CD4 + Tr cells .
15505606	0	CD4	26,29	CD25	30,34	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Tracking ex vivo-expanded CD4 + CD25 + and CD8 + CD25 + regulatory T cells after infusion to prevent donor lymphocyte infusion-induced lethal acute_graft-versus-host_disease .
15520045	0	CD4	23,26	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Control of Foxp3 + CD25 + CD4 + regulatory cell activation and function by dendritic cells .
15528313	0	CD4	62,65	CD25	66,70	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Immunotherapy of autoimmune encephalomyelitis with redirected CD4 + CD25 + T lymphocytes .
15539509	0	CD4	15,18	CD25	20,24	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Association of CD4 + CD25 + T cells with prevention of severe destructive_arthritis in Borrelia_burgdorferi-vaccinated and challenged gamma interferon-deficient mice treated with anti-interleukin-17 antibody .
15546950	0	CD4	33,36	CD25	37,41	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Only the CD62L + subpopulation of CD4 + CD25 + regulatory T cells protects from lethal acute GVHD .
15556680	0	CD4	117,120	CD25	121,125	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Overlap between molecular markers expressed by naturally occurring CD4 + CD25 + regulatory T cells and antigen specific CD4 + CD25 + and CD8 + CD28 - T_suppressor cells .
15556680	0	CD4	67,70	CD25	71,75	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Overlap between molecular markers expressed by naturally occurring CD4 + CD25 + regulatory T cells and antigen specific CD4 + CD25 + and CD8 + CD28 - T_suppressor cells .
15585928	0	CD4	77,80	CD25	81,85	CD4	CD25	920	3559	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Regulatory T-cells in antitumor therapy : isolation and functional testing of CD4 + CD25 + regulatory T-cells .
15601314	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory T cells : I. Phenotype and physiology .
15611231	0	CD4	115,118	CD25	119,123	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dendritic cells loaded with stressed tumor cells elicit long-lasting protective tumor immunity in mice depleted of CD4 + CD25 + regulatory T cells .
15611472	0	CD4	34,37	CD25	26,30	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Impaired up-regulation of CD25 on CD4 + T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart_failure .
15620457	0	CD4	44,47	CD25	48,52	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression of FOXP3 mRNA is not confined to CD4 + CD25 + T regulatory cells in humans .
15630140	0	CD4	14,17	CD25	41,45	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Conversion|nmod|CD25 Conversion|dep|cells cells|nmod|+ +|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15630140	0	CD4	36,39	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ Conversion|dep|cells Conversion|nmod|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15630140	0	CD4	36,39	CD25	41,45	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15637139	0	CD4	0,3	CD25	4,8	CD4	CD25	24932(Tax:10116)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control induction of autoimmune_hemolytic_anemia .
15640650	0	CD4	24,27	CD25	103,107	CD4	CD25	920	3669	Gene	Gene	CD25|compound|START_ENTITY percentage|nmod|CD25 due|nsubj|percentage due|nmod|decrease decrease|nmod|END_ENTITY	Increased percentage of CD4 + CD25 + regulatory T cells during septic_shock is due to the decrease of CD4 + CD25 - lymphocytes .
15640650	0	CD4	99,102	CD25	28,32	CD4	CD25	920	3669	Gene	Gene	CD25|compound|START_ENTITY decrease|nmod|CD25 due|nmod|decrease due|nsubj|percentage percentage|nmod|END_ENTITY	Increased percentage of CD4 + CD25 + regulatory T cells during septic_shock is due to the decrease of CD4 + CD25 - lymphocytes .
15649266	0	CD4	62,65	CD25	67,71	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15649266	0	CD4	74,77	CD25	67,71	CD4	CD25	920	3559	Gene	Gene	interferon-gamma|compound|START_ENTITY +|nsubj|interferon-gamma induces|parataxis|+ induces|dobj|recruitment recruitment|nmod|+ +|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15657288	0	CD4	100,103	CD25	105,109	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4 + T lymphocytes by CD4 + CD25 + regulatory T cells .
15657288	0	CD4	78,81	CD25	105,109	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY suppression|nmod|lymphocytes role|nmod|suppression play|dobj|role play|nmod|cells cells|compound|END_ENTITY	NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4 + T lymphocytes by CD4 + CD25 + regulatory T cells .
15668741	0	CD4	36,39	CD25	40,44	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The IL-6R_alpha chain controls lung CD4 + CD25 + Treg development and function during allergic airway inflammation in vivo .
15677327	0	CD4	88,91	CD25	92,96	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Down-regulation of myasthenogenic T cell responses by a dual altered peptide ligand via CD4 + CD25 + - regulated events leading to apoptosis .
15679891	0	CD4	15,18	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The changes of CD4 + CD25 + / CD4 + proportion in spleen of tumor-bearing BALB/c mice .
15679891	0	CD4	25,28	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	proportion|nummod|START_ENTITY changes|dep|proportion changes|nmod|+ +|compound|END_ENTITY	The changes of CD4 + CD25 + / CD4 + proportion in spleen of tumor-bearing BALB/c mice .
15682445	0	CD4	33,36	CD25	37,41	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	homeostasis|nummod|START_ENTITY homeostasis|compound|END_ENTITY	CD40/CD40L interaction regulates CD4 + CD25 + T reg homeostasis through dendritic cell-produced IL-2 .
15684039	0	CD4	38,41	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY compete|nmod|cells +|ccomp|compete +|nsubj|CD4 CD4|compound|END_ENTITY	CD25 + CD4 + T cells compete with naive CD4 + T cells for IL-2 and exploit it for the induction of IL-10 production .
15693142	0	CD4	161,164	CD25	166,170	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Large intestine intraepithelial lymphocytes from Apc + / + and Apc + / Min mice and their modulation by indigestible carbohydrates : the IL-15 / IL-15R_alpha complex and CD4 + CD25 + T cells are the main targets .
15699103	0	CD4	46,49	CD25	50,54	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : contact-mediated suppression by CD4 + CD25 + regulatory cells involves a granzyme_B-dependent , perforin-independent mechanism .
15699124	0	CD4	55,58	CD25	59,63	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCR8 is expressed by antigen-elicited , IL-10-producing CD4 + CD25 + T cells , which regulate Th2-mediated granuloma formation in mice .
15707399	0	CD4	55,58	CD25	59,63	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Everolimus and basiliximab permit suppression by human CD4 + CD25 + cells in vitro .
15710910	0	CD4	47,50	CD25	81,85	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nmod|cells cells|compound|END_ENTITY	A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25 + CD4 T cells in vivo .
15710910	0	CD4	86,89	CD25	81,85	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25 + CD4 T cells in vivo .
15713793	0	CD4	5,8	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD25 + CD4 + regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection : antigen-specific reactivation in vivo is critical for bystander regulation .
15725955	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells , immunotherapy of cancer , and interleukin-2 .
15728475	0	CD4	43,46	CD25	47,51	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD4	43,46	CD25	77,81	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD4	73,76	CD25	47,51	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY +|nmod|CD25 +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728508	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control innate immune reactivity after injury .
15729177	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Augmented induction of CD4 + CD25 + Treg using monoclonal antibodies to CD200R .
15731180	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	regulatory/suppressor|compound|START_ENTITY regulatory/suppressor|compound|END_ENTITY	Ontogeny of CD4 + CD25 + regulatory/suppressor T cells in human fetuses .
15743476	0	CD4	137,140	CD25	141,145	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	The role of regulatory T cells in antigen-induced arthritis : aggravation of arthritis after depletion and amelioration after transfer of CD4 + CD25 + T cells .
15743488	0	CD4	10,13	CD25	14,18	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	functioning|compound|START_ENTITY functioning|compound|END_ENTITY	Defective CD4 + CD25 + regulatory T cell functioning in collagen-induced_arthritis : an important factor in pathogenesis , counter-regulated by endogenous IFN-gamma .
15746082	0	CD4	30,33	CD25	34,38	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Rapamycin selectively expands CD4 + CD25 + FoxP3 + regulatory T cells .
15749914	0	CD4	131,134	CD25	136,140	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4 + CD25 + T cells .
15752557	0	CD4	46,49	CD25	50,54	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cure of innate intestinal immune pathology by CD4 + CD25 + regulatory T cells .
15753306	0	CD4	13,16	CD25	7,11	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY constitute|nsubj|cells END_ENTITY|parataxis|constitute	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15753306	0	CD4	13,16	CD25	90,94	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY constitute|nsubj|cells constitute|dobj|reservoir reservoir|acl:relcl|regain regain|dobj|expression expression|compound|END_ENTITY	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15753318	0	CD4	39,42	CD25	43,47	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15753318	0	CD4	39,42	CD25	83,87	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ cells|dep|generation cells|nmod|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15753318	0	CD4	79,82	CD25	43,47	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY cells|nmod|CD25 cells|dep|generation generation|nmod|+ +|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15770696	0	CD4	79,82	CD25	83,87	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD1d-restricted natural killer T cells secrete IL-2 : innate help for CD4 + CD25 + regulatory T cells ?
15784460	0	CD4	52,55	CD25	56,60	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Modulation of monocyte/macrophage function by human CD4 + CD25 + regulatory T cells .
15788479	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice .
15795282	0	CD4	62,65	CD25	67,71	CD4	CD25	920	3559	Gene	Gene	correlates|compound|START_ENTITY correlates|compound|END_ENTITY	Preferential feline_immunodeficiency_virus _ -LRB- FIV -RRB- infection of CD4 + CD25 + T-regulatory cells correlates both with surface expression of CXCR4 and activation of FIV long terminal repeat binding cellular transcriptional factors .
15807863	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid_arthritis .
15818683	0	CD4	69,72	CD25	12,16	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY sensitivity|nmod|suppression show|dobj|sensitivity CD4|parataxis|show CD4|nummod|END_ENTITY	MRL/Mp CD4 + , CD25 - T cells show reduced sensitivity to suppression by CD4 + , CD25 + regulatory T cells in vitro : a novel defect of T cell regulation in systemic_lupus_erythematosus .
15818683	0	CD4	7,10	CD25	74,78	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|show show|dobj|sensitivity sensitivity|nmod|suppression suppression|nmod|CD4 CD4|nummod|END_ENTITY	MRL/Mp CD4 + , CD25 - T cells show reduced sensitivity to suppression by CD4 + , CD25 + regulatory T cells in vitro : a novel defect of T cell regulation in systemic_lupus_erythematosus .
15837218	0	CD4	16,19	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Peptide induces CD4 -LRB- + -RRB- CD25 + and IL-10 + T cells and protection in airway allergy models .
15837817	0	CD4	70,73	CD25	74,78	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes .
15840520	0	CD4	68,71	CD25	72,76	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Different thresholds of T cell activation regulate FIV_infection of CD4 + CD25 + and CD4 + CD25 - cells .
15840697	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients .
15840697	0	CD4	72,75	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	responses|compound|START_ENTITY induction|nmod|responses control|dobj|induction control|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients .
15843512	0	CD4	97,100	CD25	101,105	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	An integral role for heme_oxygenase-1 and carbon_monoxide in maintaining peripheral tolerance by CD4 + CD25 + regulatory T cells .
15845645	0	CD4	22,25	CD25	26,30	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	BALB/c mice have more CD4 + CD25 + T regulatory cells and show greater susceptibility to suppression of their CD4 + CD25 - responder T cells than C57BL/6 mice .
15848666	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decrease of CD4 + CD25 + T cells in peripheral blood after liver transplantation : association with immunosuppression .
15853744	0	CD4	125,128	CD25	129,133	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TCR peptide vaccination in multiple_sclerosis : boosting a deficient natural regulatory network that may involve TCR-specific CD4 + CD25 + Treg cells .
15854035	0	CD4	61,64	CD25	126,130	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY END_ENTITY|dep|induces	Transfer of CD8 -LRB- + -RRB- cells induces localized hair loss whereas CD4 -LRB- + -RRB- / CD25 -LRB- - -RRB- cells promote systemic alopecia areata and CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- cells blockade disease onset in the C3H/HeJ mouse model .
15870014	0	CD4	24,27	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	In vitro expanded human CD4 + CD25 + regulatory T cells suppress effector T cell proliferation .
15870015	0	CD4	85,88	CD25	90,94	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Functional analysis of highly defined , FACS-isolated populations of human regulatory CD4 + CD25 + T cells .
15879088	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells attenuate the phosphatidylinositol 3-kinase/Akt pathway in antigen-primed immature CD8 + CTLs during functional maturation .
15880066	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Augmented Induction of CD4 + CD25 + Treg using monoclonal antibodies to CD200R .
15899580	0	CD4	76,79	CD25	70,74	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cyclophosphamide decreases the number , percentage and the function of CD25 + CD4 + regulatory T cells , which suppress induction of contact_hypersensitivity .
15905501	0	CD4	101,104	CD25	105,109	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficiency of the Src_homology_region_2_domain-containing_phosphatase_1 -LRB- SHP-1 -RRB- causes enrichment of CD4 + CD25 + regulatory T cells .
15905701	0	CD4	51,54	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	reactive|compound|START_ENTITY localization|nmod|reactive regulate|dobj|localization +|ccomp|regulate +|nsubj|END_ENTITY	CD4 + CD25 + T cells regulate colonic localization of CD4 T cells reactive to a microbial antigen .
15922716	0	CD4	96,99	CD25	48,52	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY Effects|nmod|cells Effects|dep|induction induction|nmod|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
15935883	0	CD4	101,104	CD25	106,110	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
15944246	0	CD4	14,17	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : CD4 + CD25 + regulatory T cells impaired for intestinal homing can prevent colitis .
15946248	0	CD4	10,13	CD25	15,19	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|suppress suppress|nsubj|cells cells|compound|END_ENTITY	Activated CD4 + CD25 + T cells suppress antigen-specific CD4 + and CD8 + T cells but induce a suppressive phenotype only in CD4 + T cells .
15946248	0	CD4	55,58	CD25	15,19	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY suppress|dobj|+ suppress|nsubj|cells cells|compound|END_ENTITY	Activated CD4 + CD25 + T cells suppress antigen-specific CD4 + and CD8 + T cells but induce a suppressive phenotype only in CD4 + T cells .
15958566	0	CD4	84,87	CD25	89,93	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	activities|nummod|START_ENTITY activities|compound|END_ENTITY	Tumor cyclooxygenase-2 / prostaglandin_E2-dependent promotion of FOXP3 expression and CD4 + CD25 + T regulatory cell activities in lung_cancer .
15962311	0	CD4	69,72	CD25	73,77	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine liver antigen presenting cells control suppressor activity of CD4 + CD25 + regulatory T cells .
15968737	0	CD4	18,21	CD25	13,17	CD4	CD25	920	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD25 + CD4 + T cells -LRB- Tregs -RRB- enhances the HBV-specific CD8 + T cell response primed by DNA immunization .
15972628	0	CD4	33,36	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	In contrast to effector T cells , CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand - but not to TCR-mediated cell death .
15981474	0	CD4	55,58	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	biology|compound|START_ENTITY biology|compound|END_ENTITY	The role of TCR specificity in naturally arising CD25 + CD4 + regulatory T cell biology .
15981476	0	CD4	26,29	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Selection and behavior of CD4 + CD25 + T cells in vivo : lessons from T cell receptor transgenic models .
15981486	0	CD4	52,55	CD25	56,60	CD4	CD25	920	3559	Gene	Gene	differences|nmod|START_ENTITY +|nsubj|differences +|dobj|+ +|compound|END_ENTITY	Phenotypic and functional differences between human CD4 + CD25 + and type 1 regulatory T cells .
16002076	0	CD4	47,50	CD25	39,43	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Leukocyte CD40L_deficiency affects the CD25 -LRB- + -RRB- CD4 T cell population but does not affect atherosclerosis .
16009270	0	CD4	63,66	CD25	67,71	CD4	CD25	920	3559	Gene	Gene	diversity|nmod|START_ENTITY +|nsubj|diversity +|dobj|cells cells|nummod|END_ENTITY	TCRalphabeta repertoire diversity of human naturally occurring CD4 + CD25 + regulatory T cells .
16011520	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3669	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	CD4 + CD25 + FOXP3 + regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses .
16014414	0	CD4	106,109	CD25	110,114	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4 + CD25 + regulatory cells .
16033398	0	CD4	54,57	CD25	58,62	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulation of nickel-induced T-cell responsiveness by CD4 + CD25 + cells in contact allergic patients and healthy individuals .
16036376	0	CD4	42,45	CD25	47,51	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neonatal_autoimmune_disease : influence of CD4 + CD25 + regulatory T cells .
16051465	0	CD4	33,36	CD25	28,32	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Effects of interleukin_4 on CD25 + CD4 + regulatory T cell function .
16091121	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + - regulatory T cells from mouse to man .
16106238	0	CD4	1,4	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- CD4 + CD25 + T regulatory cells in pathophysiology and therapy of immunologic_diseases -RSB- .
16108822	0	CD4	29,32	CD25	33,37	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory activity of human CD4 CD25 T cells depends on allergen concentration , type of allergen and atopy status of the donor .
16108825	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating and thymic CD4 CD25 T regulatory cells in myasthenia_gravis : effect of immunosuppressive treatment .
16116190	7	CD4	1002,1005	CD25	1006,1010	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Furthermore , passive transfer of CNS-derived CD4 + CD25 + cells in low numbers provides protection from EAE in recipient mice .
16121185	0	CD4	56,59	CD25	60,64	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Hassall 's corpuscles instruct dendritic cells to induce CD4 + CD25 + regulatory T cells in human thymus .
16122720	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the progression from periinsulitis to destructive_insulitis in murine autoimmune diabetes .
16127010	0	CD4	82,85	CD25	86,90	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Therapeutic T cell-based vaccination for neurodegenerative_disorders : the role of CD4 + CD25 + regulatory T cells .
16146782	0	CD4	23,26	CD25	27,31	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Signal transduction in CD4 + CD25 + regulatory T cells : CD25 and IL-2 .
16146782	0	CD4	23,26	CD25	53,57	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY transduction|nmod|cells transduction|dep|END_ENTITY	Signal transduction in CD4 + CD25 + regulatory T cells : CD25 and IL-2 .
16150938	0	CD4	105,108	CD25	110,114	CD4	CD25	920	3559	Gene	Gene	mechanism|compound|START_ENTITY mechanism|compound|END_ENTITY	Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4 + CD25 + T-cell-dependent mechanism .
16177055	0	CD4	47,50	CD25	52,56	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : direct suppression of B cells by CD4 + CD25 + regulatory T cells .
16177056	0	CD4	123,126	CD25	128,132	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4 + CD25 + cells with characteristics of regulatory T cells .
16177065	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells inhibit the maturation but not the initiation of an autoantibody response .
16177068	0	CD4	59,62	CD25	64,68	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Protection against autoimmunity in nonlymphopenic hosts by CD4 + CD25 + regulatory T cells is antigen-specific and requires IL-10 and TGF-beta .
16177085	0	CD4	48,51	CD25	53,57	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IFN-gamma controls the generation/activation of CD4 + CD25 + regulatory T cells in antitumor immune response .
16178275	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3669	Gene	Gene	regulatory|compound|START_ENTITY regulatory|amod|END_ENTITY	Circulating CD4 + CD25 + T regulatory and natural killer T cells in patients with myasthenia_gravis : a flow cytometry study .
16180248	0	CD4	24,27	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGF-beta1 production by CD4 + CD25 + regulatory T cells is not essential for suppression of intestinal_inflammation .
16193639	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Proportion of CD4 + CD25 + regulatory T cell is increased in the patients with ovarian_carcinoma .
16199095	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory/suppressor T cells prevent allogeneic fetus rejection in mice .
16199261	0	CD4	94,97	CD25	98,102	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Role of the T_cell_receptor_alpha_chain in the development and phenotype of naturally arising CD4 + CD25 + T cells .
16204628	0	CD4	40,43	CD25	44,48	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Vasoactive intestinal peptide generates CD4 + CD25 + regulatory T cells in vivo .
16210336	0	CD4	89,92	CD25	93,97	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , and not cyclosporin_A , preserves the highly suppressive CD27 + subset of human CD4 + CD25 + regulatory T cells .
16223778	0	CD4	84,87	CD25	89,93	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4 + CD25 + regulatory T cells .
16224273	0	CD4	69,72	CD25	73,77	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	LF 15-0195 generates synergistic tolerance by promoting formation of CD4 + CD25 + CTLA4 + T cells .
16227988	0	CD4	59,62	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lymphopenia and interleukin-2 therapy alter homeostasis of CD4 + CD25 + regulatory T cells .
16237044	0	CD4	14,17	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : CD4 + CD25 + regulatory T cells contribute to gender differences in susceptibility to experimental_autoimmune_encephalomyelitis .
16237107	0	CD4	104,107	CD25	99,103	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16257383	0	CD4	21,24	CD25	25,29	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vivo depletion of CD4 + CD25 + regulatory T cells enhances the antigen-specific primary and memory CTL response elicited by mature mRNA-electroporated dendritic cells .
16259008	0	CD4	41,44	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Genetic control of thymic development of CD4 + CD25 + FoxP3 + regulatory T lymphocytes .
16301616	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD4 + CD25 + T cells prevent the development of organ-specific autoimmune_disease by inhibiting the differentiation of autoreactive effector T cells .
16301639	0	CD4	65,68	CD25	69,73	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Bone marrow-derived dendritic cells reverse the anergic state of CD4 + CD25 + T cells without reversing their suppressive function .
16301745	0	CD4	6,9	CD25	10,14	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Where CD4 + CD25 + T reg cells impinge on autoimmune diabetes .
16304057	0	CD4	30,33	CD25	35,39	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
16314435	0	CD4	80,83	CD25	84,88	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Resolution of airway_inflammation and hyperreactivity after in vivo transfer of CD4 + CD25 + regulatory T cells is interleukin_10 dependent .
16338210	0	CD4	76,79	CD25	80,84	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD28 superagonists put a break on autoimmunity by preferentially activating CD4 + CD25 + regulatory T cells .
16338494	0	CD4	54,57	CD25	58,62	CD4	CD25	920	3559	Gene	Gene	START_ENTITY|dobj|cells cells|nummod|+ +|compound|END_ENTITY	Increased induction of allogeneic-specific cord blood CD4 + CD25 + regulatory T -LRB- Treg -RRB- cells : a comparative study of na ve and antigenic-specific cord blood Treg cells .
16339524	0	CD4	57,60	CD25	61,65	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD18 is required for optimal development and function of CD4 + CD25 + T regulatory cells .
16339542	0	CD4	118,121	CD25	122,126	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16339542	0	CD4	6,9	CD25	122,126	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|ccomp|enhances enhances|nmod|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16365425	0	CD4	15,18	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Specificity of CD4 + CD25 + regulatory T cell function in alloimmunity .
16380489	0	CD4	39,42	CD25	44,48	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Interleukin-7 is a survival factor for CD4 + CD25 + T-cells and is expressed by diabetes-suppressive_dendritic_cells .
16380492	0	CD4	53,56	CD25	57,61	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	The diabetes_type_1 locus Idd6 modulates activity of CD4 + CD25 + regulatory T-cells .
16393984	0	CD4	10,13	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Effect of CD4 + CD25 + and CD4 + CD25 - T regulatory cells on the generation of cytolytic T cell response to a self but human tumor-associated epitope in vitro .
16394018	0	CD4	17,20	CD25	21,25	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo-expanded CD4 + CD25 + immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells .
16403282	0	CD4	94,97	CD25	99,103	CD4	CD25	920	3559	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Role of LPS-stimulated human monocyte-derived dendritic cells in the modulation of autologous CD4 + CD25 + T Cell activation .
16403299	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Mechanism of CD4 + CD25 + and CD8 + regulatory T cells -- review -RSB- .
16415106	0	CD4	107,110	CD25	111,115	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4 + CD25 + cells in the recipient .
16424187	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells suppress NK cell-mediated immunotherapy of cancer .
16443370	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	The impact of CD4 + CD25 + Treg on tumor specific CD8 + T cell cytotoxicity and cancer .
16446379	0	CD4	37,40	CD25	41,45	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	B cell-deficient NOD.H-2h4 mice have CD4 + CD25 + T regulatory cells that inhibit the development of spontaneous_autoimmune_thyroiditis .
16455989	0	CD4	32,35	CD25	36,40	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Frequency of natural regulatory CD4 + CD25 + _ T lymphocytes determines the outcome of tolerance across fully mismatched MHC barrier through linked recognition of self and allogeneic stimuli .
16476010	0	CD4	15,18	CD25	20,24	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elimination of CD4 + CD25 + regulatory T cells breaks down reovirus_type_2-triggered and CpG ODN-induced prolonged mild autoimmune_insulitis in DBA/1 mice .
16479542	0	CD4	69,72	CD25	73,77	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Pertussis toxin as an adjuvant suppresses the number and function of CD4 + CD25 + T regulatory cells .
16505040	0	CD4	74,77	CD25	78,82	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of eye-derived tolerance does not depend on naturally occurring CD4 + CD25 + T regulatory cells .
16507266	0	CD4	68,71	CD25	73,77	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Isolation , identification and functional characterization of human CD4 + CD25 + Treg cells from human peripheral blood -RSB- .
16511897	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the magnitude of T-dependent humoral immune responses to exogenous antigens .
16517695	0	CD4	112,115	CD25	116,120	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting Edge : Anti-CD25 monoclonal antibody injection results in the functional inactivation , not depletion , of CD4 + CD25 + T regulatory cells .
16517699	0	CD4	93,96	CD25	97,101	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
16525991	0	CD4	47,50	CD25	52,56	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Therapeutic potential of self-antigen-specific CD4 + CD25 + regulatory T cells selected in vitro from a polyclonal repertoire .
16547230	0	CD4	118,121	CD25	122,126	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	development|compound|START_ENTITY development|compound|END_ENTITY	Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5 ' - phosphatase are required for regulation of CD4 + CD25 + T cell development .
16555237	0	CD4	119,122	CD25	123,127	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	depletion|nmod|START_ENTITY system|nmod|depletion mitigated|nmod|system mitigated|dobj|cells cells|nummod|END_ENTITY	Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4 + CD25 + cells .
16585264	0	CD4	61,64	CD25	65,69	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Endogenous IRBP can be dispensable for generation of natural CD4 + CD25 + regulatory T cells that protect from IRBP-induced retinal autoimmunity .
16586370	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T cells in skin_lesions of patients with cutaneous_leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells .
16612280	0	CD4	29,32	CD25	33,37	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Thymocyte/splenocyte-derived CD4 + CD25 + Treg stimulated by anti-CD200R2 derived dendritic cells suppress mixed leukocyte cultures and skin graft rejection .
16621989	0	CD4	33,36	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CTLA-4 engagement and regulatory CD4 + CD25 + T cells independently control CD8 + - mediated responses under costimulation blockade .
16624084	0	CD4	40,43	CD25	6,10	CD4	CD25	920	3559	Gene	Gene	responses|nummod|START_ENTITY suppress|dobj|responses +|ccomp|suppress +|nsubj|END_ENTITY	-LSB- CD4 + CD25 + regulatory T cells suppress CD4 + T cell responses in patients with persistent hepatitis_C_virus_infection -RSB- .
16630023	0	CD4	57,60	CD25	61,65	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Oestradiol potentiates the suppressive function of human CD4 CD25 regulatory T cells by promoting their proliferation .
16632602	0	CD4	58,61	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Toll-like_receptor_2 signaling modulates the functions of CD4 + CD25 + regulatory T cells .
16645171	0	CD4	41,44	CD25	45,49	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16670295	0	CD4	42,45	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	clonal|compound|START_ENTITY induction|nsubj|clonal facilitate|xcomp|induction +|ccomp|facilitate +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD25 + Foxp3 + regulatory T cells facilitate CD4 + T cell clonal anergy induction during the recovery from lymphopenia .
16670346	0	CD4	62,65	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells +|nsubj|Influence Influence|nmod|END_ENTITY	Influence of CD4 + CD25 + regulatory T cells on low/high-avidity CD4 + T cells following peptide vaccination .
16677453	0	CD4	26,29	CD25	31,35	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects and mechanism of CD4 + CD25 + T cells on the airway inflammation of asthmatic mice -RSB- .
16680369	0	CD4	12,15	CD25	16,20	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dynamics of CD4 + CD25 + T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma_japonicum .
16696899	0	CD4	98,101	CD25	102,106	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The ex vivo microenviroments in MLTC of poorly immunogenic tumor cells facilitate polarization of CD4 + CD25 + regulatory T cells .
16698419	0	CD4	17,20	CD25	22,26	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Foxp3 expressing CD4 + CD25 + and CD8 + CD28 - T regulatory cells in the peripheral blood of patients with lung_cancer and pleural_mesothelioma .
16709816	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T cells and CD4 + CD25-Foxp3 + T cells in aged mice .
16714584	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells modulate the T-cell and antibody responses in helicobacter-infected BALB/c mice .
16723631	0	CD4	15,18	CD25	19,23	CD4	CD25	920	3669	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	An increase in CD4 + CD25 + FOXP3 + regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme .
16734136	0	CD4	11,14	CD25	15,19	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|dobj|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Diminished CD4 + CD25 + T-lymphocytes in peripheral blood of patients with systemic_lupus_erythematosus .
16735139	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Tregs and NKT cells : regulators regulating regulators .
16735466	0	CD4	114,117	CD25	118,122	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4 + CD25 + cells and TGF-beta .
16741512	0	CD4	20,23	CD25	24,28	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Lack of suppressive CD4 + CD25 + FOXP3 + T cells in advanced stages of primary cutaneous_T-cell_lymphoma .
16741709	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells induced by LPS-activated bone marrow dendritic cells suppress experimental autoimmune uveoretinitis in vivo .
16751356	0	CD4	25,28	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : allogeneic CD4 + CD25 + Foxp3 + T regulatory cells suppress autoimmunity while establishing transplantation tolerance .
16751371	4	CD4	769,772	CD25	775,779	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|compound|END_ENTITY	IL-1beta drives proliferation and cytokine production by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- - -RRB- effector/memory T cells , attenuates CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cell function , and allows escape of CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- autoreactive effectors from suppression .
16758122	0	CD4	33,36	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Levels of circulating regulatory CD4 + CD25 + T cells are decreased in breast_cancer patients after vaccination with a HER2/neu peptide -LRB- E75 -RRB- and GM-CSF vaccine .
16766044	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells and CD1-restricted NKT cells do not mediate facial motoneuron survival after axotomy .
16767222	0	CD4	31,34	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Heat_shock protein 60 enhances CD4 + CD25 + regulatory T cell function via innate TLR2 signaling .
16771859	0	CD4	108,111	CD25	113,117	CD4	CD25	920	3559	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Cytotoxic_T_lymphocyte_antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4 + CD25 + regulatory T-cell-mediated suppression .
16775487	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + cell depletion from the normal CD4 + T cell pool prevents tolerance toward the intestinal flora and leads to chronic_colitis in immunodeficient mice .
16775487	0	CD4	41,44	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	pool|compound|START_ENTITY depletion|nmod|pool depletion|compound|END_ENTITY	CD4 + CD25 + cell depletion from the normal CD4 + T cell pool prevents tolerance toward the intestinal flora and leads to chronic_colitis in immunodeficient mice .
16785514	0	CD4	73,76	CD25	77,81	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Indexation as a novel mechanism of lymphocyte homeostasis : the number of CD4 + CD25 + regulatory T cells is indexed to the number of IL-2-producing cells .
16785520	0	CD4	6,9	CD25	10,14	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	FOXP3 + CD4 + CD25 + adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin_E2-dependent mechanism .
16804081	0	CD4	85,88	CD25	89,93	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4 + CD25 + T-cell-mediated regulation and type 1 diabetes development in NOD mice .
16861937	0	CD4	52,55	CD25	56,60	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppressor function of umbilical cord blood-derived CD4 + CD25 + T-regulatory cells exposed to graft-versus-host_disease drugs .
16873284	0	CD4	6,9	CD25	11,15	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|suppress suppress|nsubj|cells cells|nummod|END_ENTITY	Human CD4 + CD25 high cells suppress proliferative memory lymphocyte responses to herpes_simplex_virus_type_2 .
16887978	0	CD4	106,109	CD25	110,114	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4 + CD25 + regulatory T cells .
16888164	0	CD4	40,43	CD25	44,48	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Vasoactive intestinal peptide generates CD4 + CD25 + regulatory T cells in vivo : therapeutic applications in autoimmunity and transplantation .
16893499	0	CD4	66,69	CD25	70,74	CD4	CD25	920	3559	Gene	Gene	characterization|nmod|START_ENTITY +|nsubj|characterization +|dobj|cells cells|nummod|END_ENTITY	The phenotypic characterization of naturally occurring regulatory CD4 + CD25 + T cells .
16902287	0	CD4	27,30	CD25	32,36	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Identification of lesional CD4 + CD25 + Foxp3 + regulatory T cells in Psoriasis .
16903906	0	CD4	37,40	CD25	42,46	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The lifestyle of naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells .
16906223	0	CD4	80,83	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY cells|nmod|Tregs Role|dep|cells Role|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16914538	0	CD4	70,73	CD25	74,78	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel mechanism of action for anti-thymocyte globulin : induction of CD4 + CD25 + Foxp3 + regulatory T cells .
16917540	0	CD4	50,53	CD25	55,59	CD4	CD25	920	3559	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	PTEN inhibits IL-2 receptor-mediated expansion of CD4 + CD25 + Tregs .
16926292	0	CD4	39,42	CD25	44,48	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|express express|nsubj|cells cells|nummod|END_ENTITY	Most human thymic and peripheral-blood CD4 + CD25 + regulatory T cells express 2 T-cell receptors .
16926600	0	CD4	65,68	CD25	69,73	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Calcineurin inhibitors , but not rapamycin , reduce percentages of CD4 + CD25 + FOXP3 + regulatory T cells in renal transplant recipients .
16943228	0	CD4	19,22	CD25	23,27	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Supplementation of CD4 + CD25 + regulatory T cells suppresses experimental autoimmune uveoretinitis .
16943258	0	CD4	56,59	CD25	60,64	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	An MHC-linked locus modulates thymic differentiation of CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
16951329	0	CD4	81,84	CD25	85,89	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Protection from type_1_diabetes by invariant NK T cells requires the activity of CD4 + CD25 + regulatory T cells .
16952047	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells promotes a tumor-specific immune response in pancreas_cancer-bearing mice .
16960692	0	CD4	57,60	CD25	61,65	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Metronomic_cyclophosphamide regimen selectively depletes CD4 + CD25 + regulatory T cells and restores T and NK effector functions in end stage cancer patients .
16982872	0	CD4	22,25	CD25	26,30	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Blockade of CTLA-4 on CD4 + CD25 + regulatory T cells abrogates their function in vivo .
16982893	0	CD4	5,8	CD25	0,4	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD25 + CD4 + regulatory T cells and memory T cells prevent lymphopenia-induced proliferation of naive T cells in transient states of lymphopenia .
16987936	0	CD4	90,93	CD25	94,98	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Competition controls the rate of transition between the peripheral pools of CD4 + CD25 - and CD4 + CD25 + T cells .
16998360	0	CD4	10,13	CD25	15,19	CD4	CD25	920	3559	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Increased CD4 + CD25 + T regulatory cell activity in trauma patients depresses protective Th1 immunity .
17003369	0	CD4	45,48	CD25	49,53	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-expanded donor alloantigen-specific CD4 + CD25 + regulatory T cells promote experimental transplantation tolerance .
17011048	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3669	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + FoxP3 + T lymphocytes fail to suppress myelin_basic_protein-induced proliferation in patients with multiple_sclerosis .
17015695	0	CD4	84,87	CD25	88,92	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17024440	0	CD4	9,12	CD25	13,17	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Roles of CD4 + CD25 + T cells in the development of experimental murine allergic_conjunctivitis .
17031470	0	CD4	57,60	CD25	61,65	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction and maintenance of self tolerance : the role of CD4 + CD25 + regulatory T cells .
17038912	0	CD4	104,107	CD25	80,84	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Tregs|nmod|CD25 Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD4	76,79	CD25	108,112	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nmod|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD4	76,79	CD25	80,84	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17042799	0	CD4	45,48	CD25	49,53	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Schistosoma japonicum egg antigens stimulate CD4 CD25 T cells and modulate airway_inflammation in a murine model of asthma .
17053815	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-cell-inactivation|compound|START_ENTITY T-cell-inactivation|compound|END_ENTITY	CD4 + CD25 + regulatory T-cell-inactivation in combination with adenovirus vaccines enhances T-cell responses and protects mice from tumor challenge .
17056509	0	CD4	26,29	CD25	30,34	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of Foxp3 + CD4 + CD25 + and IL-10-secreting CD4 + CD25 + T cells during cure of colitis .
17068147	0	CD4	60,63	CD25	64,68	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Early CD30 signaling is critical for adoptively transferred CD4 + CD25 + regulatory T cells in prevention of acute_graft-versus-host_disease .
17082571	0	CD4	87,90	CD25	91,95	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Cutting edge : the phosphoinositide_3-kinase_p110_delta is critical for the function of CD4 + CD25 + Foxp3 + regulatory T cells .
17082572	0	CD4	92,95	CD25	96,100	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cyclophosphamide-induced type-1_diabetes in the NOD mouse is associated with a reduction of CD4 + CD25 + Foxp3 + regulatory T cells .
17082610	0	CD4	38,41	CD25	65,69	CD4	CD25	920	3559	Gene	Gene	targets|compound|START_ENTITY imposed|nmod|targets imposed|nmod|cells cells|compound|END_ENTITY	Distinct molecular program imposed on CD4 + T cell targets by CD4 + CD25 + regulatory T cells .
17082610	0	CD4	61,64	CD25	65,69	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct molecular program imposed on CD4 + T cell targets by CD4 + CD25 + regulatory T cells .
17082633	0	CD4	29,32	CD25	33,37	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Lipopolysaccharide-activated CD4 + CD25 + T regulatory cells inhibit neutrophil function and promote their apoptosis and death .
17100770	0	CD4	62,65	CD25	67,71	CD4	CD25	920	3559	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Evidence for immunological priming and increased frequency of CD4 + CD25 + cord blood T cells in children born to mothers with type_1_diabetes .
17105491	0	CD4	80,83	CD25	84,88	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The initial phase of graft-versus-host_disease is associated with a decrease of CD4 + CD25 + regulatory T cells in the peripheral blood of patients after allogeneic stem cell transplantation .
17109733	0	CD4	44,47	CD25	48,52	CD4	CD25	920	3559	Gene	Gene	pool|compound|START_ENTITY pool|compound|END_ENTITY	Following anti-CD25 treatment , a functional CD4 + CD25 + regulatory T-cell pool is present in renal transplant recipients .
17110462	0	CD4	53,56	CD25	57,61	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Galectin-1 : a key effector of regulation mediated by CD4 + CD25 + T cells .
17111920	0	CD4	30,33	CD25	34,38	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The role of regulatory cells CD4 + CD25 + in the development of chronic infective diseases -RSB- .
17114433	0	CD4	119,122	CD25	97,101	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Oral tolerance induction with antigen conjugated to cholera_toxin_B_subunit generates both Foxp3 + CD25 + and Foxp3-CD25 - CD4 + regulatory T cells .
17114466	0	CD4	18,21	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased natural CD4 + CD25 + regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis .
17130526	0	CD4	35,38	CD25	39,43	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A mini meta-analysis of studies on CD4 + CD25 + T cells in human type 1 diabetes : report of the Immunology of Diabetes_Society_T Cell Workshop .
17142730	0	CD4	43,46	CD25	47,51	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients .
17154263	0	CD4	14,17	CD25	19,23	CD4	CD25	920	3559	Gene	Gene	suppressor|compound|START_ENTITY suppressor|compound|END_ENTITY	Activation of CD4 + CD25 + regulatory T cell suppressor function by analogs of the selecting peptide .
17161354	0	CD4	11,14	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	expansion|compound|START_ENTITY expansion|compound|END_ENTITY	Peripheral CD4 + CD25 + Treg cell expansion in lung transplant recipients is not affected by calcineurin_inhibitors .
17175221	0	CD4	53,56	CD25	58,62	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Adoptive cell therapy using in vitro generated human CD4 + CD25 + regulatory t cells with indirect allospecificity to promote donor-specific transplantation tolerance .
17181632	0	CD4	42,45	CD25	46,50	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Frequency , function and CLA expression of CD4 + CD25 + FOXP3 + regulatory T cells in bullous pemphigoid .
17182564	0	CD4	64,67	CD25	68,72	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4 + CD25 + T cell regulatory functions .
17182566	0	CD4	5,8	CD25	0,4	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	migration|compound|START_ENTITY migration|compound|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
17182569	0	CD4	48,51	CD25	52,56	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Selective survival of naturally occurring human CD4 + CD25 + Foxp3 + regulatory T cells cultured with rapamycin .
17182968	0	CD4	15,18	CD25	19,23	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Association of CD4 + CD25 + Foxp3 + regulatory T cells with chronic activity and viral clearance in patients with hepatitis_B .
17198271	0	CD4	83,86	CD25	88,92	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Targeting acute allograft rejection by immunotherapy with ex vivo-expanded natural CD4 + CD25 + regulatory T cells .
17205133	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	CD4 + CD25 + FOXP3 + regulatory T cells suppress anti-tumor immune responses in patients with colorectal_cancer .
17210729	0	CD4	40,43	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD62L|compound|START_ENTITY CD62L|compound|END_ENTITY	Dendritic cell-expanded , islet-specific CD4 + CD25 + CD62L + regulatory T cells restore normoglycemia in diabetic_NOD mice .
17216339	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + T-cell infiltration and heme_oxygenase-1 expression correlate with tumor grade in human gliomas .
17217750	0	CD4	13,16	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- The role of CD4 + CD25 + T cell and FOXP3 in hsot acute graft rejection -RSB- .
17244157	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY -LSB-|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17244157	0	CD4	0,3	CD25	60,64	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY corrected|nsubj|-LSB- corrected|ccomp|render render|dobj|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17244157	0	CD4	55,58	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY render|dobj|CD25 corrected|ccomp|render corrected|nsubj|-LSB- -LSB-|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17258077	0	CD4	39,42	CD25	51,55	CD4	CD25	920	3559	Gene	Gene	generation|nmod|START_ENTITY IL-2-independent|dobj|generation IL-2-independent|dep|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17259178	0	CD4	25,28	CD25	30,34	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	GRAIL is up-regulated in CD4 + CD25 + T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype .
17270031	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells enhances interleukin-2-induced antitumor immunity in a mouse model of colon_adenocarcinoma .
17270282	0	CD4	101,104	CD25	21,25	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells suppression|nmod|costimulation suppression|compound|END_ENTITY	CpG DNA inhibits CD4 + CD25 + Treg suppression through direct MyD88-dependent costimulation of effector CD4 + T cells .
17270282	0	CD4	17,20	CD25	21,25	CD4	CD25	920	3559	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	CpG DNA inhibits CD4 + CD25 + Treg suppression through direct MyD88-dependent costimulation of effector CD4 + T cells .
17277105	0	CD4	48,51	CD25	67,71	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17277153	0	CD4	97,100	CD25	101,105	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4 + CD25 + regulatory T cells .
17277167	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of CD4 + CD25 + and FOXP3 + regulatory T cells during the follicular phase of the menstrual cycle : implications for human reproduction .
17289657	0	CD4	62,65	CD25	66,70	CD4	CD25	920	3559	Gene	Gene	present|compound|START_ENTITY present|compound|END_ENTITY	Dendritic_cells partially abrogate the regulatory activity of CD4 + CD25 + T cells present in the human peripheral blood .
17304105	0	CD4	20,23	CD25	25,29	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-regulatory-cells|compound|START_ENTITY T-regulatory-cells|compound|END_ENTITY	The contribution of CD4 + CD25 + T-regulatory-cells to immune suppression in sepsis .
17312121	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T cell-dependent inhibition of autoimmunity in transgenic_mice overexpressing human Bcl-2 in T lymphocytes .
17316678	0	CD4	32,35	CD25	36,40	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The clonal composition of human CD4 + CD25 + Foxp3 + cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements .
17325053	0	CD4	39,42	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY function|nsubj|T-cell suppress|ccomp|function +|ccomp|suppress +|nsubj|END_ENTITY	CD4 + CD25 + regulatory T cells suppress CD4 + T-cell function and inhibit the development of Plasmodium_berghei-specific TH1 responses involved in cerebral_malaria pathogenesis .
17331841	0	CD4	61,64	CD25	65,69	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The effect of immunosuppressive drug rapamycin on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
17350019	0	CD4	11,14	CD25	16,20	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells expand during experimental Plasmodium infection but do not prevent cerebral_malaria .
17351648	0	CD4	86,89	CD25	91,95	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , not cyclosporine , permits thymic generation and peripheral preservation of CD4 + CD25 + FoxP3 + T cells .
17353088	0	CD4	39,42	CD25	94,98	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY CD25|acl:relcl|T T|nsubj|cells cells|nmod|END_ENTITY	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17353088	0	CD4	88,91	CD25	45,49	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY cells|nmod|CD25 T|nsubj|cells END_ENTITY|acl:relcl|T	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17356295	0	CD4	15,18	CD25	20,24	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Thymus-derived CD4 + CD25 + T cells suppress the development of murine allergic_conjunctivitis .
17362490	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + transforming growth factor-beta-producing T cells are present in the lung in murine tuberculosis and may regulate the host inflammatory response .
17368474	0	CD4	33,36	CD25	37,41	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A CFSE based assay for measuring CD4 + CD25 + regulatory T cell mediated suppression of auto-antigen specific and polyclonal T cell responses .
17369190	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells are activated in vivo by recognition of self .
17369496	0	CD4	11,14	CD25	15,19	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Changes of CD4 + CD25 + Foxp3 + regulatory T cells in aged Balb/c mice .
17371928	0	CD4	45,48	CD25	50,54	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCR7 is required for the in vivo function of CD4 + CD25 + regulatory T cells .
17371959	0	CD4	33,36	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	GITR|compound|START_ENTITY GITR|compound|END_ENTITY	Follicular_lymphoma intratumoral CD4 + CD25 + GITR + regulatory T cells potently suppress CD3/CD28-costimulated autologous and allogeneic CD8 + CD25 - and CD4 + CD25 - T cells .
17371960	0	CD4	48,51	CD25	52,56	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Function of the IL-2R for thymic and peripheral CD4 + CD25 + Foxp3 + T regulatory cells .
17371975	0	CD4	110,113	CD25	114,118	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4 + CD25 + regulatory T cells .
17389235	0	CD4	60,63	CD25	64,68	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17391121	0	CD4	58,61	CD25	53,57	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR ligation blocks allograft protection by induced CD25 + CD4 + regulatory T cells without enhancing effector T-cell function .
17393103	0	CD4	12,15	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Analysis of CD4 + CD25 + regulatory T cells and Foxp3 mRNA in the peripheral blood of patients with asthma .
17404275	0	CD4	36,39	CD25	40,44	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Intestinal lamina propria retaining CD4 + CD25 + regulatory T cells is a suppressive site of intestinal inflammation .
17414712	0	CD4	75,78	CD25	79,83	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Involvement of the programmed death-1 / programmed death-1 ligand pathway in CD4 + CD25 + regulatory T-cell activity to suppress alloimmune responses .
17425604	0	CD4	116,119	CD25	121,125	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4 + CD25 + cells .
17428252	0	CD4	83,86	CD25	88,92	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Diabetes_in_non-obese diabetic mice is not associated with quantitative changes in CD4 + CD25 + Foxp3 + regulatory T cells .
17433300	0	CD4	52,55	CD25	57,61	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Schistosoma_japonicum eggs modulate the activity of CD4 + CD25 + Tregs and prevent development of colitis in mice .
17449724	0	CD4	143,146	CD25	147,151	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4 + CD25 + regulatory T cells .
17463169	0	CD4	10,13	CD25	15,19	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic_anemia .
17468835	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells decreased the antitumor activity of cytokine-induced killer -LRB- CIK -RRB- cells of lung_cancer patients .
17478450	0	CD4	76,79	CD25	80,84	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses .
17490400	0	CD4	48,51	CD25	53,57	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Daily subcutaneous injections of peptide induce CD4 + CD25 + T regulatory cells .
17495135	0	CD4	135,138	CD25	139,143	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting_cells but not by CD4 + CD25 + regulatory T cells .
17512253	0	CD4	37,40	CD25	41,45	CD4	CD25	920	3559	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	The opposite-direction modulation of CD4 + CD25 + Tregs and T helper 1 cells in acute_coronary_syndromes .
17513712	0	CD4	101,104	CD25	96,100	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CNS CD11c + cells from mice with encephalomyelitis polarize Th17 cells and support CD25 + CD4 + T cell-mediated immunosuppression , suggesting dual roles in the disease process .
17513732	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B_cell_lymphoma model .
17523950	0	CD4	157,160	CD25	161,165	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	A dual altered peptide ligand inhibits myasthenia_gravis associated responses by inducing phosphorylated extracellular-regulated kinase 1,2 that upregulates CD4 + CD25 + Foxp3 + cells .
17524860	0	CD4	59,62	CD25	63,67	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Calcitriol started in the donor , expands the population of CD4 + CD25 + T cells in renal transplant recipients .
17541623	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Tregs express an increased LAG-3 and CTLA-4 in anterior chamber-associated immune deviation .
17545218	0	CD4	149,152	CD25	91,95	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY promotes|nmod|cells promotes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17545218	0	CD4	87,90	CD25	91,95	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17545278	0	CD4	25,28	CD25	30,34	CD4	CD25	920	3559	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	The maintenance of human CD4 + CD25 + regulatory T cell function : IL-2 , IL-4 , IL-7 and IL-15 preserve optimal suppressive potency in vitro .
17548589	0	CD4	30,33	CD25	34,38	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Agonist-driven development of CD4 + CD25 + Foxp3 + regulatory T cells requires a second signal mediated by Stat6 .
17563757	0	CD4	18,21	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Downregulation of CD4 + CD25 + regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells .
17565319	0	CD4	50,53	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Regulation of transplant_arteriosclerosis by CD25 + CD4 + T cells generated to alloantigen in vivo .
17579033	0	CD4	85,88	CD25	89,93	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4 + CD25 + T regulatory cells .
17582431	0	CD4	61,64	CD25	65,69	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flow cytometry-based methods for studying signaling in human CD4 + CD25 + FOXP3 + T regulatory cells .
17591854	0	CD4	53,56	CD25	57,61	CD4	CD25	920	3559	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Expansion and tissue infiltration of an allospecific CD4 + CD25 + CD45RO + IL-7Ralphahigh cell population in solid organ transplant recipients .
17596146	0	CD4	34,37	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Evaluation of tumour-infiltrating CD4 + CD25 + FOXP3 + regulatory T cells in human cutaneous benign and atypical naevi , melanomas and melanoma metastases .
17601373	0	CD4	34,37	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	occurring|dobj|START_ENTITY occurring|nsubj|cells cells|compound|END_ENTITY	Naturally occurring self-reactive CD4 + CD25 + regulatory T cells : universal immune code .
17615291	0	CD4	99,102	CD25	103,107	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
17617562	0	CD4	83,86	CD25	87,91	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : high molecular weight hyaluronan promotes the suppressive effects of CD4 + CD25 + regulatory T cells .
17618567	0	CD4	21,24	CD25	26,30	CD4	CD25	713807(Tax:9544)	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- Characterization of CD4 + CD25 + T lymphocytes in the peripheral blood of Chinese rhesus_macaques -LRB- Macaca_mulatta -RRB- -RSB- .
17621372	0	CD4	30,33	CD25	34,38	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17627234	0	CD4	84,87	CD25	88,92	CD4	CD25	920	3559	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4 + CD25 + GITR+F oxp3 + CD62L + functional regulatory T-cells in patients with graft-versus-host_disease .
17635813	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + indirect alloreactive T cells from renal transplant patients suppress both the direct and indirect pathways of allorecognition .
17641007	0	CD4	77,80	CD25	94,98	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY conversion|nmod|cells inhibits|dobj|conversion inhibits|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17641646	0	CD4	23,26	CD25	28,32	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	generation|nmod|START_ENTITY +|nmod|generation +|nsubj|END_ENTITY	In vitro generation of CD4 + CD25 + regulatory cells from murine naive T cells .
17645467	0	CD4	21,24	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Impaired function of CD4 + / CD25 + T regulatory lymphocytes characterizes the self-limited hepatitis_A_virus_infection .
17651141	0	CD4	21,24	CD25	25,29	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immune regulation by CD4 + CD25 + T cells and interleukin-10 in birch pollen-allergic patients and non-allergic controls .
17684039	0	CD4	69,72	CD25	73,77	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Blockade of chronic graft-versus-host_disease by alloantigen-induced CD4 + CD25 + Foxp3 + regulatory T cells in nonlymphopenic hosts .
17687106	0	CD4	104,107	CD25	108,112	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4 + CD25 + Foxp3 + regulatory T cells .
17711492	0	CD4	19,22	CD25	24,28	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dynamic changes in CD4 + CD25 + -LRB- high -RRB- T cell apoptosis after the diagnosis of type_1_diabetes .
17764450	0	CD4	12,15	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD25 + regulatory T cells correlate with chronic hepatitis_B_infection .
17785792	0	CD4	53,56	CD25	57,61	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17785792	0	CD4	73,76	CD25	57,61	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells suppression|nmod|transcription transcription|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17785799	0	CD4	172,175	CD25	176,180	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4 + CD25 + regulatory T cells .
17826032	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + naturally occurring regulatory T cells and not lymphopenia play a role in the pathogenesis of iodide-induced autoimmune_thyroiditis in NOD-H2h4 mice .
17851131	0	CD4	98,101	CD25	29,33	CD4	CD25	920	3669	Gene	Gene	T|compound|START_ENTITY IFN-gamma|nmod|T cells|amod|IFN-gamma induction|nmod|cells inhibit|dobj|induction inhibit|nsubj|frequency frequency|nmod|END_ENTITY	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
17868677	0	CD4	20,23	CD25	24,28	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural regulatory -LRB- CD4 + CD25 + FOXP + -RRB- T cells control the production of pro-inflammatory cytokines during Plasmodium_chabaudi adami infection and do not contribute to immune evasion .
17868905	0	CD4	54,57	CD25	60,64	CD4	CD25	920	3559	Gene	Gene	characterisation|nmod|START_ENTITY END_ENTITY|nsubj|characterisation	Phenotypic and functional characterisation of porcine CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- regulatory T cells .
17875988	0	CD4	21,24	CD25	65,69	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|acl|+ +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD4	61,64	CD25	25,29	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells END_ENTITY|acl|+	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD4	61,64	CD25	65,69	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17896973	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells and TGF-beta in mucosal immune system : the good and the bad .
17898053	0	CD4	133,136	CD25	7,11	CD4	CD25	920	3559	Gene	Gene	activation|compound|START_ENTITY macaques|nmod|activation macaques|nsubj|T-cell T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
17911604	0	CD4	55,58	CD25	59,63	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
17912440	0	CD4	51,54	CD25	55,59	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Imatinib impairs the proliferation and function of CD4 + CD25 + regulatory T cells in a dose-dependent manner .
17917056	0	CD4	15,18	CD25	19,23	CD4	CD25	920	3559	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Natural Tregs , CD4 + CD25 + inhibitory hybridomas , and their cell contact dependent suppression .
17920698	0	CD4	111,114	CD25	64,68	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY effector|nmod|CD25 effector|dep|allows allows|xcomp|antigen-specific antigen-specific|nsubj|distinction distinction|nmod|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17920698	0	CD4	32,35	CD25	117,121	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY allows|nsubj|expression effector|dep|allows effector|nmod|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17920698	0	CD4	32,35	CD25	64,68	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY allows|nsubj|expression allows|xcomp|antigen-specific antigen-specific|nsubj|distinction distinction|nmod|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17920698	0	CD4	58,61	CD25	117,121	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY distinction|nmod|CD25 antigen-specific|nsubj|distinction allows|xcomp|antigen-specific effector|dep|allows effector|nmod|END_ENTITY	High cell surface expression of CD4 allows distinction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- antigen-specific effector T cells from CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine experimental autoimmune encephalomyelitis .
17944116	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CD4 + CD25 + T cells in rheumatic_mitral_stenosis .
17956583	0	CD4	12,15	CD25	189,193	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY Increase|nmod|CD25 +|nsubj|Increase +|parataxis|using using|xcomp|cyclophosphamide cyclophosphamide|xcomp|eliminate eliminate|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Increase of CD4 + CD25 + regulatory T cells in the peripheral blood of patients with metastatic_carcinoma : a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4 + CD25 + T lymphocytes .
17956583	0	CD4	184,187	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	lymphocytes|nummod|START_ENTITY eliminate|dobj|lymphocytes cyclophosphamide|xcomp|eliminate using|xcomp|cyclophosphamide +|parataxis|using +|nsubj|Increase Increase|nmod|END_ENTITY	Increase of CD4 + CD25 + regulatory T cells in the peripheral blood of patients with metastatic_carcinoma : a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4 + CD25 + T lymphocytes .
17956583	0	CD4	184,187	CD25	189,193	CD4	CD25	920	3559	Gene	Gene	lymphocytes|nummod|START_ENTITY lymphocytes|compound|END_ENTITY	Increase of CD4 + CD25 + regulatory T cells in the peripheral blood of patients with metastatic_carcinoma : a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4 + CD25 + T lymphocytes .
17966042	0	CD4	97,100	CD25	101,105	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	The severity of systemic_lupus_erythematosus_negatively_correlates with the increasing number of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells during repeated plasmapheresis treatments of patients .
17967941	0	CD4	129,132	CD25	71,75	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY +|advcl|cells +|nsubj|impact impact|nmod|inhibition inhibition|nmod|Foxp3 Foxp3|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17967941	0	CD4	67,70	CD25	71,75	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17968332	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells in autoimmune_diseases .
17980384	0	CD4	21,24	CD25	25,29	CD4	CD25	493775(Tax:9685)	493953(Tax:9685)	Gene	Gene	depletion|nmod|START_ENTITY +|nmod|depletion +|nsubj|END_ENTITY	In vivo depletion of CD4 + CD25 + regulatory T cells in cats .
17981641	0	CD4	19,22	CD25	24,28	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IL-2 signaling and CD4 + CD25 + Foxp3 + regulatory T cells .
17981643	0	CD4	48,51	CD25	53,57	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Factors regulating apoptosis and homeostasis of CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells are new therapeutic targets .
17982096	0	CD4	74,77	CD25	78,82	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Resolution of Der p1-induced allergic airway inflammation is dependent on CD4 + CD25 + Foxp3 + regulatory cells .
17982458	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
17982458	0	CD4	94,97	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells induce|dobj|apoptosis +|ccomp|induce +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
17990114	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells have divergent effects on intestinal_inflammation in IL-10 gene-deficient mice .
18021363	0	CD4	11,14	CD25	16,20	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + T cells prevent thymic dysfunction in experimental chronic colitis .
18025172	0	CD4	21,24	CD25	25,29	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2_and_4-1BB signaling .
18025205	0	CD4	17,20	CD25	21,25	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18027108	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells : from basic research to potential therapeutic use .
18032693	0	CD4	45,48	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Regulation of the NFAT pathway discriminates CD4 + CD25 + regulatory T cells from CD4 + CD25 - helper T cells .
18032693	0	CD4	45,48	CD25	83,87	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY discriminates|dobj|cells discriminates|nmod|END_ENTITY	Regulation of the NFAT pathway discriminates CD4 + CD25 + regulatory T cells from CD4 + CD25 - helper T cells .
18032693	0	CD4	79,82	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY discriminates|nmod|CD25 discriminates|dobj|cells cells|compound|END_ENTITY	Regulation of the NFAT pathway discriminates CD4 + CD25 + regulatory T cells from CD4 + CD25 - helper T cells .
18036640	0	CD4	45,48	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation of NK_T-like_CD3 + CD56 + cells and CD4 + CD25 + -LRB- hi -RRB- regulatory T cells with VEGF and TNFalpha in ascites from advanced ovarian_cancer : Association with platinum resistance and prognosis in patients receiving first-line , platinum-based chemotherapy .
18038774	0	CD4	12,15	CD25	16,20	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Changes of CD4 + CD25 + T cells in the spleen of mice infected with Toxoplasma_gondii -RSB- .
18042719	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce alternative activation of human monocytes/macrophages .
18053016	0	CD4	38,41	CD25	42,46	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The functional insufficiency of human CD4 + CD25 high T-regulatory cells in allergic_asthma is subjected to TNF-alpha modulation .
18058571	0	CD4	10,13	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Targeting CD4 + CD25 + FoxP3 + regulatory T-cells for the augmentation of cancer immunotherapy .
18066074	0	CD4	57,60	CD25	61,65	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Prevention of acute and chronic allograft rejection with CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
18070209	0	CD4	31,34	CD25	35,39	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional characterization of CD4 + CD25 + regulatory T cells differentiated in vitro from bone marrow-derived haematopoietic cells of psoriasis patients with a family history of the disorder .
18091047	0	CD4	90,93	CD25	94,98	CD4	CD25	920	3559	Gene	Gene	homeostasis|compound|START_ENTITY homeostasis|compound|END_ENTITY	Transforming_growth_factor-beta / transforming_growth_factor-betaRII signaling may regulate CD4 + CD25 + T-regulatory cell homeostasis and suppressor function in feline AIDS_lentivirus_infection .
18092144	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The role of CD4 + CD25 + T regulatory cells in autoimmune_diseases .
18159952	0	CD4	169,172	CD25	173,177	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Repeated 0.5-Gy gamma irradiation attenuates autoimmune_disease in MRL-lpr/lpr mice with suppression of CD3 + CD4-CD8-B220 + T-cell proliferation and with up-regulation of CD4 + CD25 + Foxp3 + regulatory T cells .
18171291	0	CD4	0,3	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	CD4 -LRB- + -RRB- -LRB- and not CD25 + -RRB- T cells are the predominant interleukin-10-producing cells in the circulation of filaria-infected patients .
18178825	0	CD4	50,53	CD25	54,58	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expansion improves in vivo regulation by CD4 + CD25 + regulatory T cells .
18178849	0	CD4	64,67	CD25	68,72	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha antagonism generates a population of antigen-specific CD4 + CD25 + T cells that inhibit protective immunity in murine histoplasmosis .
18190656	0	CD4	25,28	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Ex vivo-expanded natural CD4 + CD25 + regulatory T cells synergize with host T-cell depletion to promote long-term survival of allografts .
18204854	0	CD4	56,59	CD25	60,64	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Aerobic training increases the stimulated percentage of CD4 + CD25 + in older men but not older women .
18221522	0	CD4	89,92	CD25	93,97	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4 + CD25 + regulatory T cells in Peyer 's patches in an orally tolerized , collagen-induced_arthritis mouse model .
18231887	0	CD4	25,28	CD25	29,33	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Alteration of peripheral CD4 + CD25 + regulatory T lymphocytes in pregnancy and pre-eclampsia .
18248531	0	CD4	38,41	CD25	33,37	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD_127 - and FoxP3 + expression on CD25 + CD4 + T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type_1_diabetes_mellitus patients .
18256318	0	CD4	99,102	CD25	103,107	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Autologous bone marrow transplantation in autoimmune_arthritis restores immune homeostasis through CD4 + CD25 + Foxp3 + regulatory T cells .
18261176	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	CD4 + CD25 + FOXP3 + regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H .
18269341	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory T cells : a therapeutic target for liver_diseases .
18270248	0	CD4	38,41	CD25	42,46	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR .
18270250	0	CD4	25,28	CD25	47,51	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|nmod|FOXP3 FOXP3|compound|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18270250	0	CD4	43,46	CD25	47,51	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18272926	0	CD4	27,30	CD25	54,58	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD4	50,53	CD25	31,35	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells END_ENTITY|dep|cells	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD4	50,53	CD25	54,58	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18281535	0	CD4	26,29	CD25	30,34	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Enhanced functionality of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells in the peripheral blood of patients with prostate_cancer .
18287134	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + FOXP3 + T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple_myeloma following allogeneic stem cell transplantation .
18295349	0	CD4	75,78	CD25	79,83	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Matured human monocyte-derived dendritic cells -LRB- MoDCs -RRB- induce expansion of CD4 + CD25 + FOXP3 + T cells lacking regulatory properties .
18298587	0	CD4	58,61	CD25	62,66	CD4	CD25	920	3669	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Observational support for an immunoregulatory role of CD3 + CD4 + CD25 + IFN-gamma + blood lymphocytes in kidney transplant recipients with good long-term graft outcome .
18304352	0	CD4	15,18	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The control of CD4 + CD25 + Foxp3 + regulatory T cell survival .
18308639	0	CD4	70,73	CD25	74,78	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGFbeta1_deficiency does not affect the generation and maintenance of CD4 + CD25 + FOXP3 + putative Treg cells , but causes their numerical inadequacy and loss of regulatory function .
18315924	0	CD4	31,34	CD25	36,40	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	development|compound|START_ENTITY development|compound|END_ENTITY	-LSB- Inhibitory Effect of CCL20 on CD4 + CD25 + regulatory T cell development in mouse thymus -RSB- .
18323802	0	CD4	140,143	CD25	144,148	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Vaccination of B-CLL patients with autologous dendritic cells can change the frequency of leukemia antigen-specific CD8 + T cells as well as CD4 + CD25 + FoxP3 + regulatory T cells toward an antileukemia response .
18328445	0	CD4	53,56	CD25	57,61	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Resveratrol induces the suppression of tumor-derived CD4 + CD25 + regulatory T cells .
18341610	0	CD4	13,16	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells inhibits local tumour growth in a mouse model of B_cell_lymphoma .
18355912	0	CD4	34,37	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Expansion of hepatitis_C-specific CD4 + CD25 + regulatory T cells after viral clearance : a mechanism to limit collateral damage ?
18360256	0	CD4	37,40	CD25	41,45	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY drugs|nmod|+ Impact|nmod|drugs +|dep|Impact +|dep|+ +|compound|END_ENTITY	Impact of immunosuppressive drugs on CD4 + CD25 + FOXP3 + regulatory T cells : does in vitro evidence translate to the clinical setting ?
18388182	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD4 + CD25 + Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6 .
18397268	0	CD4	73,76	CD25	77,81	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4 + CD25 + T cells .
18423565	0	CD4	52,55	CD25	57,61	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Grass pollen immunotherapy induces Foxp3-expressing CD4 + CD25 + cells in the nasal mucosa .
18431238	0	CD4	82,85	CD25	86,90	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depleting anti-CD4 monoclonal antibody -LRB- GK1 .5 -RRB- treatment : influence on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
18438410	0	CD4	73,76	CD25	77,81	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	A critical function for TGF-beta signaling in the development of natural CD4 + CD25 + Foxp3 + regulatory T cells .
18440785	0	CD4	35,38	CD25	39,43	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Defective functions of circulating CD4 + CD25 + and CD4 + CD25 - T cells in patients with chronic_ordinary_urticaria .
18453563	0	CD4	82,85	CD25	86,90	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
18462346	0	CD4	58,61	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
18469093	0	CD4	89,92	CD25	93,97	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
18477692	0	CD4	66,69	CD25	70,74	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18477692	0	CD4	86,89	CD25	90,94	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18478932	0	CD4	26,29	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	detection|compound|START_ENTITY detection|compound|END_ENTITY	-LSB- Clinical significance of CD4 + CD25 + regulatory T-cells detection in tumor-draining lymph nodes of nonsmall_cell_lung_cancer patients -RSB- .
18480308	0	CD4	10,13	CD25	14,18	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Activated CD4 + CD25 + regulatory T cells inhibit osteoclastogenesis and collagen-induced_arthritis .
18480441	0	CD4	36,39	CD25	41,45	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-generated antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells control the severity of herpes simplex virus-induced ocular_immunoinflammatory_lesions .
18484654	0	CD4	31,34	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Effects of cryopreservation on CD4 + CD25 + T cells of HIV-1_infected individuals .
18485782	0	CD4	15,18	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The regulatory CD4 + CD25 + T cells have a limited role on pathogenesis of infection with Trypanosoma_cruzi .
18490730	0	CD4	11,14	CD25	15,19	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells selectively inhibit the spontaneous form of lymphopenia-induced_proliferation of naive T cells .
18493168	0	CD4	28,31	CD25	32,36	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of thymus-derived CD4 + CD25 + T cells abrogates the suppressive effects of alpha-galactosylceramide treatment on experimental_allergic_conjunctivitis .
18493981	0	CD4	34,37	CD25	40,44	CD4	CD25	920	3559	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
18510697	0	CD4	40,43	CD25	44,48	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Foxp3 expression on normal and leukemic CD4 + CD25 + T cells implicated in human T-cell_leukemia_virus_type-1 is inconsistent with Treg cells .
18511516	0	CD4	15,18	CD25	19,23	CD4	HO-1	12504(Tax:10090)	15368(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Suppression by CD4 + CD25 + regulatory T cells is dependent on expression of heme_oxygenase-1 in antigen-presenting cells .
18512811	0	CD4	12,15	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|appos|cells cells|nummod|END_ENTITY	Function of CD4 + , CD25 + Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting_cells and effector T cells .
18538611	0	CD4	19,22	CD25	23,27	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The involvement of CD4 + CD25 + T cells in the acute phase of Trypanosoma_cruzi_infection .
18557727	0	CD4	106,109	CD25	101,105	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	New insights into mechanisms of spontaneous liver transplant tolerance : the role of Foxp3-expressing CD25 + CD4 + regulatory T cells .
18559659	0	CD4	64,67	CD25	68,72	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Rapamycin monotherapy in patients with type 1 diabetes modifies CD4 + CD25 + FOXP3 + regulatory T-cells .
18563290	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decrease in CD4 + CD25 + and CD8 + CD28 + T cells in interstitial_pneumonitis associated with rheumatic_disease .
18566388	0	CD4	25,28	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18576316	0	CD4	69,72	CD25	13,17	CD4	CD25	920	3559	Gene	Gene	sensitivity|nmod|START_ENTITY +|dep|sensitivity +|appos|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
18576316	0	CD4	8,11	CD25	13,17	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Reduced CD4 + , CD25 - T cell sensitivity to the suppressive function of CD4 + , CD25high , CD127 - / low regulatory T cells in patients with active systemic_lupus_erythematosus .
18580479	0	CD4	24,27	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	In vitro expanded human CD4 + CD25 + regulatory T cells are potent suppressors of T-cell-mediated xenogeneic responses .
18587005	0	CD4	0,3	CD25	4,8	CD4	CD25	404704(Tax:9823)	396814(Tax:9823)	Gene	Gene	PD1|compound|START_ENTITY PD1|compound|END_ENTITY	CD4 + CD25 + FoxP3 + PD1 - regulatory T cells in acute and stable relapsing-remitting multiple_sclerosis and their modulation by therapy .
18589160	0	CD4	59,62	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Adoptive transfer of transplantation tolerance mediated by CD4 + CD25 + and CD8 + CD28 - regulatory T cells induced by anti-donor-specific T-cell vaccination .
18606654	0	CD4	83,86	CD25	47,51	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY phenotype|nmod|CD25 phenotype|compound|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
18615246	0	CD4	62,65	CD25	67,71	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Isolation , flow cytometric analysis , and suppression assay of CD4 + CD25 + T-regulatory cells .
18627509	0	CD4	76,79	CD25	80,84	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In pregnant mice , the infection of Toxoplasma_gondii causes the decrease of CD4 + CD25 + - regulatory T cells .
18641303	0	CD4	45,48	CD25	50,54	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	differentiation|nummod|START_ENTITY differentiation|compound|END_ENTITY	IFN regulatory factor-1 negatively regulates CD4 + CD25 + regulatory T cell differentiation by repressing Foxp3 expression .
18642784	0	CD4	15,18	CD25	20,24	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	-LSB- Expression of CD4 + CD25 + CD127 -LRB- low / - -RRB- T cells in patients with systemic_lupus_erythematosus -RSB- .
18658093	0	CD4	18,21	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expanded CD4 + CD25 + Foxp3 + regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation .
18668589	0	CD4	89,92	CD25	93,97	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An early sympathetic nervous system influence exacerbates collagen-induced_arthritis via CD4 + CD25 + cells .
18681851	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + CD127lo regulatory T cells does not increase allergen-driven T cell activation .
18684927	0	CD4	60,63	CD25	65,69	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional characterization and gene expression analysis of CD4 + CD25 + regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin .
18719339	0	CD4	71,74	CD25	129,133	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells circulating|nmod|END_ENTITY	Sepsis is characterized by the increases in percentages of circulating CD4 + CD25 + regulatory T cells and plasma levels of soluble CD25 .
18719339	0	CD4	71,74	CD25	75,79	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Sepsis is characterized by the increases in percentages of circulating CD4 + CD25 + regulatory T cells and plasma levels of soluble CD25 .
18723571	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	populations|compound|START_ENTITY populations|compound|END_ENTITY	CD4 + CD25 + T-cell populations expressing CD134 and GITR are associated with disease activity in patients with Wegener 's _ granulomatosis .
18725261	0	CD4	17,20	CD25	22,26	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The influence of CD4 + CD25 + Foxp3 + regulatory T cells on the immune response to rotavirus_infection .
18754436	0	CD4	51,54	CD25	56,60	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Identification of correlations between numbers of CD4 + CD25 + Treg cells , levels of sera anti-AChR antibodies and transfer growth factor-beta in patients with myasthenia_gravis -RSB- .
18768841	0	CD4	42,45	CD25	46,50	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-12R beta 2 promotes the development of CD4 + CD25 + regulatory T cells .
18772548	0	CD4	10,13	CD25	14,18	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cell-depletion|compound|START_ENTITY cell-depletion|compound|END_ENTITY	Effect of CD4 + CD25 + T cell-depletion on acute lethal infection of mice with Trypanosoma congolense .
18775028	0	CD4	73,76	CD25	78,82	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Inhibition of phosphoantigen-mediated gammadelta T-cell proliferation by CD4 + CD25 + FoxP3 + regulatory T cells .
18778287	0	CD4	13,16	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Expansion of CD4 + CD25 + Foxp3 + T cells by bone marrow-derived dendritic cells .
18792402	0	CD4	25,28	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Resting B cells expand a CD4 + CD25 + Foxp3 + Treg population via TGF-beta3 .
18799222	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells are infected and activated during acute_FIV_infection .
18806350	0	CD4	29,32	CD25	33,37	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Relationship of frequency of CD4 + CD25 + Foxp3 + regulatory T cells with disease progression in antiretroviral-naive HIV-1_infected Chinese .
18813112	0	CD4	75,78	CD25	79,83	CD4	CD25	920	3559	Gene	Gene	activation|nmod|START_ENTITY suppression|nmod|activation +|nmod|suppression +|nsubj|END_ENTITY	In vitro suppression of xenoimmune-mediated macrophage activation by human CD4 + CD25 + regulatory T cells .
18815284	0	CD4	89,92	CD25	93,97	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Anti-CD3 prevents factor_VIII inhibitor development in hemophilia_A mice by a regulatory CD4 + CD25 + - dependent mechanism and by shifting cytokine production to favor a Th1 response .
18824533	0	CD4	103,106	CD25	108,112	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Schistosoma_mansoni antigens modulate experimental allergic_asthma in a murine model : a major role for CD4 + CD25 + Foxp3 + T cells independent of interleukin-10 .
18827184	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD4 + CD25 + T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes , suggesting separate pathways of activation by Th1 and Th2 responses .
18832672	0	CD4	84,87	CD25	89,93	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CD47 controls the in vivo proliferation and homeostasis of peripheral CD4 + CD25 + Foxp3 + regulatory T cells that express CD103 .
18832695	0	CD4	39,42	CD25	44,48	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY CD127|nummod|+ CD127|compound|END_ENTITY	XCL1 enhances regulatory activities of CD4 + CD25 -LRB- high -RRB- CD127 -LRB- low / - -RRB- T cells in human allergic_asthma .
18844067	0	CD4	17,20	CD25	22,26	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	-LSB- Significance of CD4 + CD25 + CD127 -LRB- low -RRB- regulatory T cells and notch1 pathway in the pathogenesis of aplastic_anemia -RSB- .
18925576	0	CD4	57,60	CD25	61,65	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased diabetes development and decreased function of CD4 + CD25 + Treg in the absence of a functional DAP12 adaptor protein .
18928784	0	CD4	63,66	CD25	69,73	CD4	CD25	407098(Tax:9913)	281861(Tax:9913)	Gene	Gene	Foxp3|nummod|START_ENTITY Foxp3|compound|END_ENTITY	Subpopulations of bovine WC1 -LRB- + -RRB- gammadelta T cells rather than CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells act as immune regulatory cells ex vivo .
18954555	0	CD4	20,23	CD25	24,28	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Deficiency of mouse CD4 + CD25 + Foxp3 + regulatory T cells in xenogeneic pig thymus-grafted nude_mice suffering from autoimmune_diseases .
18981109	0	CD4	6,9	CD25	11,15	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + Foxp3 + regulatory T cells do not constitutively express IL-35 .
18981115	0	CD4	27,30	CD25	32,36	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Imatinib_mesylate inhibits CD4 + CD25 + regulatory T cell activity and enhances active immunotherapy against BCR-ABL - _ tumors .
18981144	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells protect against T_cell-mediated_fulminant_hepatitis in a TGF-beta-dependent manner in mice .
18981159	0	CD4	95,98	CD25	100,104	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Measles_virus_infection in adults induces production of IL-10 and is associated with increased CD4 + CD25 + regulatory T cells .
18981295	0	CD4	76,79	CD25	80,84	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4 + CD25 + Foxp3 + T regulatory cells in mycobacterial_infection .
19016717	0	CD4	53,56	CD25	57,61	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Dasatinib inhibits the proliferation and function of CD4 + CD25 + regulatory T cells .
19020538	0	CD4	50,53	CD25	54,58	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Kinetics , function and bone marrow trafficking of CD4 + CD25 + FOXP3 + regulatory T cells in myelodysplastic_syndromes -LRB- MDS -RRB- .
19031706	0	CD4	80,83	CD25	85,89	CD4	CD25	920	3559	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Immunosuppression induced by measles_virus in adult patients is not related to CD4 + CD25 + regulatory T cell induction -RSB- .
19034003	0	CD4	25,28	CD25	44,48	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY -LSB-|acl|corrected corrected|dobj|Foxp3 Foxp3|compound|END_ENTITY	Pancreatic islets induce CD4 -LRB- + -RRB- -LSB- corrected -RSB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- -LSB- corrected -RSB- T-cell regulated tolerance to HY-mismatched skin grafts .
19040605	0	CD4	68,71	CD25	72,76	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Recurrent superantigen exposure in vivo leads to highly suppressive CD4 + CD25 + and CD4 + CD25 - T cells with anergic and suppressive genetic signatures .
19051021	0	CD4	26,29	CD25	30,34	CD4	CD25	920	3559	Gene	Gene	Diminution|nmod|START_ENTITY +|nsubj|Diminution +|dobj|cells cells|nummod|END_ENTITY	Diminution of Circulating CD4 + CD25 high T cells in na ve Crohn 's _ disease .
19056449	0	CD4	67,70	CD25	71,75	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4 + CD25 + T regulatory cells .
19060917	0	CD4	121,124	CD25	125,129	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neonatal bacillus Calmette-Gu rin vaccination inhibits de novo allergic inflammatory response in mice via alteration of CD4 + CD25 + T-regulatory cells .
19077880	0	CD4	56,59	CD25	61,65	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Hepatic stellate cells preferentially expand allogeneic CD4 + CD25 + FoxP3 + regulatory T cells in an IL-2-dependent manner .
19080493	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- The role of CD4 + CD25 + regulatory T cells in the pathogenesis of chronic abacterial_prostatitis / chronic_pelvic_pain_syndrome -RSB- .
19103952	0	CD4	15,18	CD25	19,23	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Development of CD4 + CD25 + FoxP3 + regulatory T cells from cord blood hematopoietic progenitor cells .
19104677	0	CD4	22,25	CD25	26,30	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	The role of ACAID and CD4 + CD25 + FOXP3 + regulatory T cells on CTL function against MHC alloantigens .
19134327	0	CD4	9,12	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	Role|nmod|START_ENTITY +|nsubj|Role +|dobj|cells cells|nummod|END_ENTITY	-LSB- Role of CD4 + CD25 high regulatory T cells in the pathogenesis of intrahepatic_cholestasis_of_pregnancy -RSB- .
19146957	0	CD4	51,54	CD25	55,59	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The significantly enhanced frequency of functional CD4 + CD25 + Foxp3 + T regulatory cells in therapeutic dose aspirin-treated mice .
19152963	0	CD4	58,61	CD25	62,66	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Selective deregulation in chemokine signaling pathways of CD4 + CD25 -LRB- hi -RRB- CD127 -LRB- lo -RRB- / -LRB- - -RRB- regulatory T cells in human allergic_asthma .
19155973	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Upregulating CD4 + CD25 + FOXP3 + regulatory T cells in pancreatic lymph nodes in diabetic_NOD mice by adjuvant immunotherapy .
19162239	0	CD4	57,60	CD25	28,32	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reduces|nmod|cells reduces|dobj|expression expression|compound|END_ENTITY	Bromelain treatment reduces CD25 expression on activated CD4 + T cells in vitro .
19164169	0	CD4	38,41	CD25	42,46	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	pool|compound|START_ENTITY pool|compound|END_ENTITY	Seminal fluid drives expansion of the CD4 + CD25 + T regulatory cell pool and induces tolerance to paternal alloantigens in mice .
19171090	0	CD4	13,16	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- The role of CD4 + CD25 + T cells in the mechanism of myasthenia_gravis in children and adults -RSB- .
19171501	0	CD4	130,133	CD25	134,138	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Modulation of dendritic cells using granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- delays type 1 diabetes by enhancing CD4 + CD25 + regulatory T cell function .
19173720	0	CD4	17,20	CD25	21,25	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Low frequency of CD4 + CD25 + Treg in SLE patients : a heritable trait associated with CTLA4 and TGFbeta gene variants .
19188932	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + regulatory T cell response by glatiramer_acetate in type 1 diabetes .
19190764	0	CD4	53,56	CD25	83,87	CD4	CD25	920	3559	Gene	Gene	T-lymphocytes|compound|START_ENTITY T-lymphocytes|acl|expressing expressing|dobj|END_ENTITY	Chronic_brucellosis patients retain low frequency of CD4 + T-lymphocytes expressing CD25 and CD28 after Escherichia_coli LPS stimulation of PHA-cultured PBMCs .
19208087	0	CD4	28,31	CD25	33,37	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Chemokine responsiveness of CD4 + CD25 + regulatory and CD4 + CD25 - T cells from atopic and nonatopic donors .
19210524	0	CD4	140,143	CD25	144,148	CD4	CD25	920	3559	Gene	Gene	forkhead_box_P3|compound|START_ENTITY forkhead_box_P3|compound|END_ENTITY	Cell contact , prostaglandin_E -LRB- 2 -RRB- and transforming_growth_factor_beta_1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25 -LRB- High -RRB- forkhead_box_P3 + regulatory T cells .
19218134	0	CD4	9,12	CD25	13,17	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Role of CD4 + CD25 + Foxp3 + regulatory T cells in type 2 diabetic_nephropathy -RSB- .
19221040	0	CD4	81,84	CD25	85,89	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4 + CD25 + Foxp3 + T regulatory cells that protects against graft-versus-host_disease .
19229109	0	CD4	27,30	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	Tregs|nummod|START_ENTITY Tregs|compound|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
19234174	0	CD4	118,121	CD25	122,126	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human dendritic cells produce TGF-beta_1 under the influence of lung_carcinoma cells and prime the differentiation of CD4 + CD25 + Foxp3 + regulatory T cells .
19251786	0	CD4	58,61	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Local effector failure in mesothelioma is not mediated by CD4 + CD25 + T-regulator cells .
19268553	0	CD4	55,58	CD25	59,63	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Gamma irradiation alters the phenotype and function of CD4 + CD25 + regulatory T cells .
19277040	0	CD4	34,37	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
19281793	0	CD4	6,9	CD25	11,15	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Mouse CD4 + CD25 + T regulatory cells are protected from autologous complement mediated injury by Crry and CD59 .
19292855	0	CD4	28,31	CD25	32,36	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Immunomagnetic isolation of CD4 + CD25 + FoxP3 + natural T regulatory lymphocytes for clinical applications .
19303058	0	CD4	96,99	CD25	100,104	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation between the degree of immune activation , production of IL-2 and FOXP3 expression in CD4 + CD25 + T regulatory cells in HIV-1 infected persons under HAART .
19327546	0	CD4	38,41	CD25	42,46	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Feedback loop of immune regulation by CD4 + CD25 + Treg .
19342412	0	CD4	21,24	CD25	25,29	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Global impairment of CD4 + CD25 + FOXP3 + regulatory T cells in idiopathic_pulmonary_fibrosis .
19349365	0	CD4	44,47	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Surveillance of antigen-presenting cells by CD4 + CD25 + regulatory T cells in autoimmunity : immunopathogenesis and therapeutic implications .
19362679	0	CD4	61,64	CD25	65,69	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tim-3-Galectin-9 pathway involves the suppression induced by CD4 + CD25 + regulatory T cells .
19362742	0	CD4	63,66	CD25	67,71	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	CTLA4Ig_gene_transfer_alleviates_abortion in mice by expanding CD4 + CD25 + regulatory T cells and inducing indoleamine_2 ,3 - dioxygenase .
19364517	0	CD4	10,13	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + T cells in peripheral blood of celiac_disease patients : correlation with dietary treatment .
19401397	0	CD4	134,137	CD25	138,142	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intact extracellular matrix and the maintenance of immune tolerance : high molecular weight hyaluronan promotes persistence of induced CD4 + CD25 + regulatory T cells .
19410243	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Ex vivo expanded human CD4 + CD25 + Foxp3 + regulatory T cells prevent lethal xenogenic graft_versus_host_disease -LRB- GVHD -RRB- .
19438599	0	CD4	53,56	CD25	59,63	CD4	CD25	920	3559	Gene	Gene	CD39|nummod|START_ENTITY CD39|compound|END_ENTITY	Characterization of regulatory T cells identified as CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD39 -LRB- + -RRB- in patients with active tuberculosis .
19448155	0	CD4	17,20	CD25	21,25	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
19462377	0	CD4	22,25	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19462377	0	CD4	48,51	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	proliferation|compound|START_ENTITY control|dobj|proliferation required|xcomp|control required|nmod|Treg Treg|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19486771	0	CD4	10,13	CD25	14,18	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + regulatory T cells in tolerance induced by portal venous injection .
19522766	0	CD4	41,44	CD25	0,4	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY occurring|dobj|cells shedding|advcl|occurring END_ENTITY|acl|shedding	CD25 shedding by human natural occurring CD4 + CD25 + regulatory T cells does not inhibit the action of IL-2 .
19522766	0	CD4	41,44	CD25	45,49	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	CD25 shedding by human natural occurring CD4 + CD25 + regulatory T cells does not inhibit the action of IL-2 .
19533418	0	CD4	73,76	CD25	77,81	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Low molecular weight fraction secreted by SKOV3 cells expands peripheral CD4 + CD25 + regulatory T cells and enhances their suppressive capacity .
19534876	0	CD4	26,29	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- The relationship between CD4 + CD25 + regulatory T cell in the peripheral blood and poor or nonresponsiveness to hepatitis_B vaccine -RSB- .
19535644	0	CD4	117,120	CD25	121,125	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4 + CD25 + Foxp3 + T regulatory cells .
19540813	0	CD4	92,95	CD25	96,100	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Conserved anti-proliferative effect and poor inhibition of TNFalpha secretion by regulatory CD4 + CD25 + T cells in patients with systemic_lupus_erythematosus .
19545723	0	CD4	9,12	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	Elevated CD4 + / CD25 + T-cell frequency and function during hepatitis_C virus recurrence after liver transplantation .
19561360	0	CD4	68,71	CD25	72,76	CD4	CD25	920	3559	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Docosahexaenoic_acid reduces suppressive and migratory functions of CD4 + CD25 + regulatory T-cells .
19564386	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 - T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted_fever_rickettsiosis .
19564598	0	CD4	58,61	CD25	62,66	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Secretory phospholipase A2-IID is an effector molecule of CD4 + CD25 + regulatory T cells .
19595120	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Analysis of CD4 + CD25 + Foxp3 + regulatory T cells in patients of haemorrhagic_fever_with_renal_syndrome -RSB- .
19622090	0	CD4	44,47	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Seasonal changes in suppressive capacity of CD4 + CD25 + T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25 + population .
19624523	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + T cell depletion impairs tolerance induction in a murine model of asthma .
19635903	0	CD4	38,41	CD25	110,114	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY levels|nmod|cells revealed|nsubj|levels revealed|nmod|coexpression coexpression|nmod|END_ENTITY	High levels of human antigen-specific CD4 + T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 -LRB- OX40 -RRB- .
19654865	0	CD4	58,61	CD25	63,67	CD4	CD25	920	3559	Gene	Gene	levels|nmod|START_ENTITY +|nsubj|levels +|dobj|cells cells|nummod|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
19665867	0	CD4	92,95	CD25	96,100	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4 + CD25 + Foxp3 + regulatory T cell population .
19667094	0	CD4	25,28	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Mast cells down-regulate CD4 + CD25 + T regulatory cell suppressor function via histamine H1 receptor interaction .
19667946	0	CD4	50,53	CD25	54,58	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Extracorporeal photophoresis augments function of CD4 + CD25 + FoxP3 + regulatory T cells by triggering adenosine production .
19706340	0	CD4	61,64	CD25	65,69	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naloxone can improve the anti-tumor immunity by reducing the CD4 + CD25 + Foxp3 + regulatory T cells in BALB/c mice .
19709757	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of inducible CD4 + CD25 + Foxp3 + regulatory T lymphocytes by porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- .
19715524	0	CD4	119,122	CD25	124,128	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tolerogenic semimature dendritic cells induce effector T-cell hyporesponsiveness by the activation of antigen-specific CD4 + CD25 + T-regulatory cells .
19715817	0	CD4	75,78	CD25	79,83	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin -- rather than FK506 -- might promote allograft tolerance induced by CD4 + CD25 + regulatory T cells .
19719913	0	CD4	100,103	CD25	104,108	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	-LSB- Human plasmacytoid dendritic cells from patients with chronic hepatitis_B induce the generation of CD4 + CD25 + Treg in vitro -RSB- .
19739430	0	CD4	28,31	CD25	32,36	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion of FOXP3-positive CD4 + CD25 + T cells associated with disease activity in atopic_dermatitis .
19740328	0	CD4	137,140	CD25	142,146	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4 + CD25 + Foxp3 + regulatory T cells .
19752528	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Circulating CD4 + CD25 bright FOXP3 + T cells are up-regulated by biological therapies and correlate with the clinical response in psoriasis patients .
19766059	0	CD4	4,7	CD25	8,12	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The CD4 + CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage .
19770521	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Tregs resolve experimental lung_injury in mice and are present in humans with acute_lung_injury .
19772948	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice .
19817769	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast_cancer model .
19833887	0	CD4	56,59	CD25	60,64	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Idd9 .1 locus controls the suppressive activity of FoxP3 + CD4 + CD25 + regulatory T-cells .
19843574	0	CD4	73,76	CD25	77,81	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Signaling through TLR7 enhances the immunosuppressive activity of murine CD4 + CD25 + T regulatory cells .
19845018	0	CD4	98,101	CD25	102,106	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4 + CD25 + Foxp3 + regulatory T cells .
19845755	0	CD4	25,28	CD25	29,33	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Absence of modulation of CD4 + CD25 regulatory T cells in CTCL patients treated with bexarotene .
19853929	0	CD4	25,28	CD25	56,60	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY Conversion|nmod|CD25 T|nsubj|Conversion T|nmod|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19853929	0	CD4	50,53	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY T|nmod|CD25 T|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19882655	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma_japonicum is TLR2 dependent .
19900372	0	CD4	35,38	CD25	40,44	CD4	CD25	920	3669	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	-LSB- Association of PD-1 expression on CD4 + CD25 nt/hi CD127 lo regulatory T cells with disease progression in HIV-1_infected patients -RSB- .
19903662	0	CD4	85,88	CD25	89,93	CD4	CD25	920	3559	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Rapamycin , unlike cyclosporine_A , enhances suppressive functions of in vitro-induced CD4 + CD25 + Tregs .
19916283	0	CD4	126,129	CD25	131,135	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Influence of electroacupuncture and moxibustion and their treated mouse serum on the proliferation of the cultured splenetic CD4 + CD25 + regulatory T cells of tumor-bearing mice -RSB- .
19923444	0	CD4	49,52	CD25	54,58	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Activated CD8 + T-effector/memory cells eliminate CD4 + CD25 + Foxp3 + T-suppressor cells from tumors via FasL mediated apoptosis .
19946957	0	CD4	106,109	CD25	111,115	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY methods|nmod|analysis cell|nmod|methods +|nsubj|cell +|dobj|cells cells|nummod|END_ENTITY	Magnetic cell sorting and flow cytometry sorting methods for the isolation and function analysis of mouse CD4 + CD25 + Treg cells .
19958642	0	CD4	21,24	CD25	25,29	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Association between CD4 + CD25 + Foxp3 + regulatory T cells and serum transforming_growth_factor_beta_1 in patients with chronic_hepatitis_B -RSB- .
19961805	0	CD4	19,22	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	comparison|nmod|START_ENTITY comparison|dep|END_ENTITY	-LSB- The comparison of CD4 -LRB- + -RRB- ; CD25 -LRB- high -RRB- ; Foxp3 -LRB- + -RRB- ; regulatory T cells between neonatal cord blood and adult peripheral blood . -RSB- .
19966302	0	CD4	0,3	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses .
20046022	0	CD4	84,87	CD25	88,92	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Crossreactivity of antibodies to canine CD25 and Foxp3 and identification of canine CD4 + CD25 + Foxp3 + cells in canine peripheral blood .
20059575	0	CD4	61,64	CD25	66,70	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	1,25-dihydroxyvitamin _ D3 enhances the ability of transferred CD4 + CD25 + cells to modulate T helper type 2-driven asthmatic responses .
20079283	0	CD4	15,18	CD25	20,24	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	inactivation|compound|START_ENTITY inactivation|compound|END_ENTITY	-LSB- The effect of CD4 + CD25 + regulatory T cell inactivation combined with levofloxacin on murine tuberculosis -RSB- .
20081380	0	CD4	59,62	CD25	64,68	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20095846	0	CD4	35,38	CD25	39,43	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Gamma-ray resistance of regulatory CD4 + CD25 + Foxp3 + T cells in mice .
20128236	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium_yoelii infection in susceptible BALB/c mice .
20137434	0	CD4	43,46	CD25	25,29	CD4	CD25	920	3669	Gene	Gene	expressions|nmod|START_ENTITY expressions|nmod|END_ENTITY	-LSB- Study on expressions of CD25 and CD127 in CD4 + peripheral T lymphocytes of patients with rheumatoid_arthritis -RSB- .
20139172	0	CD4	80,83	CD25	84,88	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
20204427	0	CD4	52,55	CD25	34,38	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY characteristics|nmod|cell characteristics|nmod|END_ENTITY	Distributional characteristics of CD25 and CD127 on CD4 + T cell subsets in chronic HCV_infection .
20230668	0	CD4	53,56	CD25	58,62	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of ConA on early activation and function of CD4 + CD25 + Treg cells in mice -RSB- .
20305583	0	CD4	78,81	CD25	82,86	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4 + CD25 + Foxp3 + regulatory T cells in allotransplantation .
20337996	0	CD4	40,43	CD25	44,48	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCL22 is involved in the recruitment of CD4 + CD25 high T cells into tuberculous pleural_effusions .
20347251	0	CD4	76,79	CD25	80,84	CD4	CD25	920	3559	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Is it necessary to deplete the lymphokine activated killers ' populations of CD4 + CD25 + lymphocytes ?
20357265	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia .
20357481	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + IL-10 + T cells in HDM-allergic asthmatic children with or without SIT .
20378024	0	CD4	0,3	CD25	4,8	CD4	CD25	407098(Tax:9913)	281861(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T regulatory cells are not involved in oral desensitization .
20382706	0	CD4	46,49	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	START_ENTITY|nsubj|IFN-gamma IFN-gamma|compound|END_ENTITY	Antigen-specific CD25 - Foxp3 - IFN-gamma -LRB- high -RRB- CD4 + T cells restrain the development of experimental_allergic_encephalomyelitis by suppressing Th17 .
20382886	0	CD4	54,57	CD25	59,63	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20394727	0	CD4	120,123	CD25	124,128	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4 + CD25 + Foxp3 + regulatory T cells and down-regulates cardiac allograft rejection .
20412132	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + T cells switches the whey-allergic response from immunoglobulin E - to immunoglobulin free light chain-dependent .
20421648	0	CD4	37,40	CD25	43,47	CD4	CD25	920	3559	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|amod|END_ENTITY	LAG-3 expression defines a subset of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells that are expanded at tumor sites .
20448211	0	CD4	10,13	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Deficient CD4 + CD25 + T regulatory cell function in patients with abdominal_aortic_aneurysms .
20463654	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice .
20487626	0	CD4	51,54	CD25	55,59	CD4	CD25	920	3559	Gene	Gene	Cells|nummod|START_ENTITY Cells|compound|END_ENTITY	IL-35 , an anti-inflammatory cytokine which expands CD4 + CD25 + Treg Cells .
20497692	0	CD4	0,3	CD25	73,77	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|converted converted|nmod|END_ENTITY	CD4 + Foxp3 + regulatory T cells converted by rapamycin from peripheral CD4 + CD25 -LRB- - -RRB- naive T cells display more potent regulatory ability in vitro .
20501849	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Selective depletion of CD4 + CD25 + Foxp3 + regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels .
20514074	0	CD4	70,73	CD25	74,78	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phenotypic and functional switch of macrophages induced by regulatory CD4 + CD25 + T cells in mice .
20522244	0	CD4	30,33	CD25	34,38	CD4	CD25	920	3559	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Foxp3 regulates human natural CD4 + CD25 + regulatory T-cell-mediated suppression of xenogeneic response .
20528588	0	CD4	84,87	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY inducing|nmod|cells +|advcl|inducing +|nsubj|defect defect|nmod|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
20570629	0	CD4	128,131	CD25	81,85	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY restrain|dobj|CD25 mechanisms|acl:relcl|restrain mechanisms|nmod|cell cell|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20570629	0	CD4	77,80	CD25	132,136	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY mechanisms|nmod|cell mechanisms|acl:relcl|restrain restrain|dobj|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20570629	0	CD4	77,80	CD25	81,85	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20574434	0	CD4	47,50	CD25	51,55	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Gene regulation by 1,25-dihydroxyvitamin _ D3 in CD4 + CD25 + cells is enabled by IL-2 .
20635785	0	CD4	45,48	CD25	50,54	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY patterns|nmod|+ patterns|parataxis|END_ENTITY	Expression patterns of HLA-DR + or HLA-DR - on CD4 + / CD25 + + / CD127low regulatory T cells in patients with allergy .
20646510	0	CD4	94,97	CD25	99,103	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- Effect of transcatheter_renal_arterial_embolization combined with cryoablation on regulatory CD4 + CD25 + T lymphocytes in the peripheral blood of patients with advanced renal_carcinoma -RSB- .
20650872	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + regulatory T cell depletion improves the graft-versus-tumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation .
20655262	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Decrease in CD4 + CD25 + FoxP3 + Treg cells after pulmonary resection in the treatment of cavity multidrug-resistant_tuberculosis .
20698203	0	CD4	31,34	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The variation of expression of CD4 + CD25 + Foxp3 + regulatory T cells in patients with Helicobacter_pylori_infection and eradication .
20713627	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells , dendritic cells , and circulating cytokines in uncomplicated malaria : do different parasite species elicit similar host responses ?
20723203	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppressed the indirect xenogeneic immune response mediated by porcine epithelial cell pulsed dendritic cells .
20729906	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|dobj|+ +|compound|END_ENTITY	CD4 + CD25 + but not CD4 + Foxp3 + T cells as a regulatory subset in primary_biliary_cirrhosis .
20801101	0	CD4	81,84	CD25	85,89	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deacetylase inhibitor trichostatin_A down-regulates Foxp3 expression and reduces CD4 + CD25 + regulatory T cells .
20844003	0	CD4	65,68	CD25	69,73	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Progesterone increases systemic and local uterine proportions of CD4 + CD25 + Treg cells during midterm pregnancy in mice .
20854875	0	CD4	20,23	CD25	25,29	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naturally occurring CD4 + CD25 + FOXP3 + T-regulatory cells are increased in chronic_myeloid_leukemia patients not in complete cytogenetic remission and can be immunosuppressive .
20858449	0	CD4	32,35	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating regulatory T cells -LRB- CD4 + CD25 + FOXP3 + -RRB- decrease in breast_cancer patients after vaccination with a modified MHC class II HER2/neu -LRB- AE37 -RRB- peptide .
20870943	0	CD4	35,38	CD25	95,99	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	differentiation|nummod|START_ENTITY induce|dobj|differentiation induce|nmod|END_ENTITY	Tolerogenic dendritic cells induce CD4 + CD25hiFoxp3 + regulatory T cell differentiation from CD4 + CD25 - / loFoxp3 - effector T cells .
20871628	0	CD4	96,99	CD25	101,105	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	2-Gy whole-body irradiation significantly alters the balance of CD4 + CD25 - T effector cells and CD4 + CD25 + Foxp3 + T regulatory cells in mice .
20875655	0	CD4	93,96	CD25	97,101	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cardiac allograft acceptance induced by blockade of CD40-CD40L costimulation is dependent on CD4 + CD25 + regulatory T cells .
20883403	0	CD4	12,15	CD25	17,21	CD4	CD25	920	3669	Gene	Gene	FoxP3|nummod|START_ENTITY FoxP3|compound|END_ENTITY	Circulating CD4 + CD25 high FoxP3 + T cells vary in different clinical forms of leprosy .
20888597	0	CD4	32,35	CD25	36,40	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Effects of hypertonic saline on CD4 + CD25 + Foxp3 + regulatory T cells after hemorrhagic_shock in relation to iNOS and cytokines .
20923543	0	CD4	22,25	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The frequency of CD25 + CD4 + and FOXP3 + regulatory T cells in ectopic endometrium and ectopic decidua .
20930173	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells protect the proinflammatory activation of human umbilical vein endothelial cells .
20941599	0	CD4	22,25	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Natural and induced T CD4 + CD25 + FOXP3 + regulatory T cells .
20966498	0	CD4	55,58	CD25	59,63	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- The role of stromal mast cells in the modification of CD4 + CD25 + Foxp regulatory T cells , Th17 lymphocytes and cytotoxic lymphocytes Tc1 in the development and progression of tumor -RSB- .
20977501	0	CD4	53,56	CD25	58,62	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neonatal BCG vaccination induces IL-10 production by CD4 + CD25 + T cells .
20977632	0	CD4	45,48	CD25	50,54	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of CD39 by human peripheral blood CD4 + CD25 + T cells denotes a regulatory memory phenotype .
21039425	0	CD4	35,38	CD25	40,44	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Reduced levels of both circulating CD4 + CD25 + CD127 -LRB- low/neg -RRB- and CD4 + CD8 -LRB- neg -RRB- invariant natural killer regulatory T cells in stable heart transplant recipients .
21044123	0	CD4	91,94	CD25	95,99	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	PAS-1 , an Ascaris_suum protein , modulates allergic_airway_inflammation via CD8 + y TCR + and CD4 + CD25 + FoxP3 + T cells .
21048105	0	CD4	88,91	CD25	92,96	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Methyl_gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4 + CD25 + regulatory T cells .
21059286	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- The roles of CD4 + CD25 + T regulatory cells and Foxp3 mRNA expression in the subjects with and without responses to hepatitis_B virus vaccination -RSB- .
21072213	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells depletion may attenuate the development of silica-induced lung_fibrosis in mice .
21092106	0	CD4	0,3	CD25	4,8	CD4	CD25	920	493953(Tax:9685)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells from FIV + cats induce a unique anergic profile in CD8 + lymphocyte targets .
21094858	0	CD4	74,77	CD25	79,83	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Astragalus membranaceus injection delayed allograft survival related with CD4 + CD25 + regulatory T cells .
21105040	0	CD4	24,27	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated frequencies of CD4 CD25 CD127lo regulatory T cells is associated to poor prognosis in patients with acute_myeloid_leukemia .
21108468	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg regulate the contribution of CD8 + T-cell subsets in repopulation of the lymphopenic environment .
21115120	0	CD4	24,27	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Selective impairment of CD4 + CD25 + Foxp3 + regulatory T cells by paclitaxel is explained by Bcl-2 / Bax mediated apoptosis .
21129004	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	CD4 + / CD25 + cells in systemic inflammation in COPD .
21134345	0	CD4	24,27	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Proportional changes of CD4 + CD25 + Foxp3 + regulatory T cells in maternal peripheral blood during pregnancy and labor at term and preterm .
21208558	0	CD4	43,46	CD25	49,53	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY frequency|nmod|+ Analysis|nmod|frequency Analysis|dep|END_ENTITY	-LSB- Analysis of frequency of peripheral blood CD4 + ; CD25 -LRB- high -RRB- ; Tregs and CD4 + ; CD25 -LRB- low -RRB- ; T cells and expression of PD-1 in SLE and RA patients -RSB- .
21208558	0	CD4	43,46	CD25	76,80	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY frequency|nmod|+ Analysis|nmod|frequency Analysis|dep|END_ENTITY	-LSB- Analysis of frequency of peripheral blood CD4 + ; CD25 -LRB- high -RRB- ; Tregs and CD4 + ; CD25 -LRB- low -RRB- ; T cells and expression of PD-1 in SLE and RA patients -RSB- .
21244371	0	CD4	100,103	CD25	104,108	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibitor of PI3Ky ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4 + CD25 + FoxP3 + regulatory T cells .
21249305	0	CD4	100,103	CD25	104,108	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	proliferation|compound|START_ENTITY proliferation|compound|END_ENTITY	Cyclosporin_A-treated dendritic cells may affect the outcome of organ transplantation by decreasing CD4 + CD25 + regulatory T cell proliferation .
21249500	0	CD4	54,57	CD25	59,63	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Identification , frequency , activation and function of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells in children with juvenile_idiopathic_arthritis .
21255222	0	CD4	29,32	CD25	34,38	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Novel role of aquaporin-4 in CD4 + CD25 + T regulatory cell development and severity of Parkinson 's _ disease .
21319979	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Analysis of CD4 + CD25 + Foxp3 + regulatory T cells in HIV-exposed seronegative persons and HIV-infected persons with different disease progressions .
21347662	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Depletion of CD4 + CD25 + Foxp3 + regulatory T cells with anti-CD25 antibody may exacerbate the 1,3-b-glucan-induced lung inflammatory response in mice .
21398613	0	CD4	37,40	CD25	41,45	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Impairment of regulatory capacity of CD4 + CD25 + regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves ' _ disease .
21437244	0	CD4	52,55	CD25	57,61	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracerebral human regulatory T cells : analysis of CD4 + CD25 + FOXP3 + T cells in brain_lesions and cerebrospinal fluid of multiple_sclerosis patients .
21447271	0	CD4	1,4	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- CD4 + CD25 + Foxp3 + T lymphocytes : naturally occuring regulatory T cells -RSB- .
21450832	0	CD4	13,16	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Retention of CD4 + CD25 + FoxP3 + regulatory T cells in the liver after therapy-induced hepatitis_C_virus eradication in humans .
21469094	0	CD4	111,114	CD25	116,120	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Steady state migratory RelB + langerin + dermal dendritic cells mediate peripheral induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells .
21472340	0	CD4	63,66	CD25	91,95	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	CD4	87,90	CD25	91,95	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21485079	0	CD4	81,84	CD25	85,89	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effect of Chinese drugs for invigorating qi and tonifying shen on expression of CD4 + CD25 + regulatory T cells in spleen and maternal-fetal interface of abortion-prone mice -RSB- .
21518973	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
21519344	0	CD4	78,81	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY cells|dep|stimulation Induction|nmod|cells Induction|nmod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21533081	0	CD4	51,54	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TLR2-dependent induction of IL-10 and Foxp3 + CD25 + CD4 + regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo .
21557210	0	CD4	0,3	CD25	7,11	CD4	CD25	920	3559	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21557210	0	CD4	46,49	CD25	7,11	CD4	CD25	920	3559	Gene	Gene	population|compound|START_ENTITY cells|dep|population cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21570402	0	CD4	96,99	CD25	100,104	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	A method of generating antibodies against exogenously administered self-antigen by manipulating CD4 + CD25 + regulatory T cells .
21576985	0	CD4	31,34	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Impaired Ca regulation of CD4 CD25 regulatory T cells from pediatric asthma .
21600126	0	CD4	29,32	CD25	33,37	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Study of fas-mediated Foxp3 + CD4 + CD25 + Treg cell apoptosis in patients with systemic_lupus_erythematosus -RSB- .
21604971	0	CD4	64,67	CD25	76,80	CD4	CD25	920	3559	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Transfer of cell membrane components via trogocytosis occurs in CD4 + Foxp3 + CD25 + regulatory T-cell contact-dependent suppression .
21604973	0	CD4	25,28	CD25	29,33	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased frequencies of CD4 + CD25 + Foxp3 + cells and the potent CD103 + subset in peripheral lymph_nodes correlate with autoimmune_disease predisposition in some strains of mice .
21633918	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Increased frequency of CD4 + CD25 -LRB- high -RRB- FoxP3 + regulatory T cells in patients with hepatocellular_carcinoma .
21651772	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	helper|compound|START_ENTITY helper|compound|END_ENTITY	Expansion of CD4 + CD25 + helper T cells without regulatory function in smoking and COPD .
21652515	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
21664396	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	IFN-y|compound|START_ENTITY IFN-y|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFN-y + human induced T regulatory cells are induced by interferon-y and suppress alloresponses nonspecifically .
21674673	0	CD4	25,28	CD25	30,34	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Increased frequencies of CD4 + CD25 + FOXP3 + regulatory T cells in human nasal_inverted_papilloma .
21691076	0	CD4	113,116	CD25	117,121	CD4	CD25	920	3559	Gene	Gene	Forkhead_Boxp3|compound|START_ENTITY Forkhead_Boxp3|compound|END_ENTITY	Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute_lung_injury by expanding CD4 + CD25 + Forkhead_Boxp3 -LRB- FOXP3 -RRB- + regulatory T cells and balancing anti- and pro-inflammatory factors .
21702013	0	CD4	109,112	CD25	113,117	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21702013	0	CD4	109,112	CD25	43,47	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY juvenile_idiopathic_arthritis|nmod|Treg cells|amod|juvenile_idiopathic_arthritis patients|nmod|cells cells|nmod|patients suppression|dep|cells suppression|nmod|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21702013	0	CD4	39,42	CD25	113,117	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY suppression|nmod|CD25 suppression|dep|cells cells|nmod|patients patients|nmod|cells cells|amod|juvenile_idiopathic_arthritis juvenile_idiopathic_arthritis|nmod|Treg Treg|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21715555	0	CD4	70,73	CD25	74,78	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Uncoupling of proliferation and cytokines from suppression within the CD4 + CD25 + Foxp3 + T-cell compartment in the 1st year of human type 1 diabetes .
21726337	0	CD4	26,29	CD25	31,35	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Maternal Foxp3 expressing CD4 + CD25 + and CD4 + CD25 - regulatory T-cell populations are enriched in human early normal pregnancy decidua : a phenotypic study of paired decidual and peripheral blood samples .
21734238	0	CD4	115,118	CD25	119,123	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin and IL-2 reduce lethal acute_graft-versus-host_disease associated with increased expansion of donor type CD4 + CD25 + Foxp3 + regulatory T cells .
21744325	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + and CD4 + CD2 + high regulatory T cells in disseminated and localized forms of allergic_contact_dermatitis : relation to specific cytokines .
21749646	0	CD4	29,32	CD25	76,80	CD4	CD25	920	3559	Gene	Gene	memory|compound|START_ENTITY resistance|nmod|memory T|nsubj|resistance T|nmod|cells cells|amod|suppression suppression|nmod|END_ENTITY	Relative resistance of human CD4 -LRB- + -RRB- memory T cells to suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells .
21799858	0	CD4	23,26	CD25	107,111	CD4	CD25	920	3559	Gene	Gene	Requirement|nmod|START_ENTITY +|nsubj|Requirement +|parataxis|generated generated|nsubj|cells cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21799858	0	CD4	95,98	CD25	107,111	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY +|nmod|CD127 +|parataxis|generated generated|nsubj|cells cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21824530	0	CD4	82,85	CD25	87,91	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4 + CD25 + FoxP3 + T reg cells in vivo .
21829534	0	CD4	30,33	CD25	123,127	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells NY-ESO-1-specific|advcl|circulating NY-ESO-1-specific|nsubj|T T|dep|cells cells|acl|undetectable undetectable|nmod|compartment compartment|compound|END_ENTITY	NY-ESO-1-specific circulating CD4 + T cells in ovarian_cancer patients are prevalently T -LRB- H -RRB- 1 type cells undetectable in the CD25 + FOXP3 + Treg compartment .
21831456	0	CD4	18,21	CD25	22,26	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Identification of CD4 + CD25 high Foxp3 + T cells in ovine peripheral blood .
21834806	0	CD4	13,16	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Detection of CD4 + CD25 + FOXP3 + regulatory T cells in peripheral blood of patients with chronic_autoimmune_urticaria .
21843083	0	CD4	32,35	CD25	36,40	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Neem leaf glycoprotein inhibits CD4 + CD25 + Foxp3 + Tregs to restrict murine tumor growth .
21915633	0	CD4	24,27	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Behavior of circulating CD4 + CD25 + Foxp3 + regulatory T cells in colon_cancer patients undergoing surgery .
21926188	0	CD4	26,29	CD25	54,58	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY Unmasking|nmod|cells Unmasking|nmod|cells cells|nummod|END_ENTITY	Unmasking of autoreactive CD4 T cells by depletion of CD25 regulatory T cells in systemic_lupus_erythematosus .
21958749	0	CD4	50,53	CD25	54,58	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Isolation , expansion and functional assessment of CD4 + CD25 + FoxP3 + regulatory T cells and Tr1 cells from uremic patients awaiting kidney transplantation .
21958951	0	CD4	10,13	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Host CD25 + CD4 + Foxp3 + regulatory T cells primed by anti-CD137 mAbs inhibit graft-versus-host_disease .
21975289	0	CD4	14,17	CD25	19,23	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The impact of CD4 + CD25 + T cells in the tumor microenvironment of hepatocellular_carcinoma .
21982068	0	CD4	94,97	CD25	99,103	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Neutralization of interleukin-10 or transforming growth factor-b decreases the percentages of CD4 + CD25 + Foxp3 + regulatory T cells in septic mice , thereby leading to an improved survival .
21983870	0	CD4	26,29	CD25	30,34	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations of peripheral CD4 + CD25 + Foxp3 + T regulatory cells in mice with STZ-induced diabetes .
22005288	0	CD4	13,16	CD25	18,22	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
22007491	0	CD4	33,36	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of 89SrCl2 treatment on CD4 + CD25 + regulatory T cells and its Foxp3 mRNA expression in cancer patients with bone metastases -RSB- .
22019644	0	CD4	67,70	CD25	103,107	CD4	CD25	920	3559	Gene	Gene	detection|nmod|START_ENTITY assay|nmod|detection T|nsubj|assay T|dobj|cells cells|nmod|co-expression co-expression|nmod|END_ENTITY	A novel assay for detection of hepatitis_C virus-specific effector CD4 -LRB- + -RRB- T cells via co-expression of CD25 and CD134 .
22079196	0	CD4	36,39	CD25	40,44	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Foxp3 is critical for human natural CD4 + CD25 + regulatory T cells to suppress alloimmune response .
22112394	0	CD4	35,38	CD25	39,43	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IFN-b induces the proliferation of CD4 + CD25 + Foxp3 + regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple_sclerosis .
22125630	0	CD4	29,32	CD25	35,39	CD4	CD25	920	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Partial depletion of natural CD4 CD25 regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza_A_virus infection .
22155204	0	CD4	69,72	CD25	13,17	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY proliferation|nmod|T cells|compound|proliferation suppress|dobj|cells B|ccomp|suppress B|nsubj|END_ENTITY	Human CD19 -LRB- + -RRB- CD25 -LRB- high -RRB- B regulatory cells suppress proliferation of CD4 -LRB- + -RRB- T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells .
22164498	0	CD4	63,66	CD25	68,72	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of excreted/secreted antigens of Toxoplasma_gondii on CD4 + CD25 + Foxp3 + T cells and NK cells of melanoma-bearing mice -RSB- .
22178876	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells protect endothelial function impaired by oxidized low density lipoprotein via the KLF-2 transcription factor .
22197557	0	CD4	113,116	CD25	117,121	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|nummod|END_ENTITY	FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4 + CD25 - responder T cells , but not CD4 + CD25 + regulatory T cells .
22211712	0	CD4	29,32	CD25	45,49	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FoxP3|nummod|START_ENTITY role|nmod|FoxP3 END_ENTITY|nsubj|role	The immunoregulatory role of CD4 FoxP3 CD25 regulatory T cells in lungs of mice infected with Bordetella_pertussis .
22290507	0	CD4	47,50	CD25	52,56	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Epicutaneous immunization with DNP-BSA induces CD4 + CD25 + Treg cells that inhibit Tc1-mediated CS .
22310911	0	CD4	44,47	CD25	48,52	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-5 promotes induction of antigen-specific CD4 + CD25 + T regulatory cells that suppress autoimmunity .
22332874	0	CD4	13,16	CD25	17,21	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Expansion of CD4 + CD25 + FOXP3 + regulatory T cells in infants of mothers with type_1_diabetes .
22348656	0	CD4	16,19	CD25	21,25	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Distribution of CD4 + CD25 high FoxP3 + regulatory T-cells in umbilical cord blood .
22349593	0	CD4	49,52	CD25	44,48	CD4	CD25	407098(Tax:9913)	281861(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro effects of dexamethasone on bovine CD25 + CD4 + and CD25-CD4 + cells .
22367425	0	CD4	28,31	CD25	32,36	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Pachyman treatment improves CD4 + CD25 + Treg counts and serum interleukin_4 and interferon y levels in a mouse model of Kawasaki_disease .
22379819	0	CD4	95,98	CD25	99,103	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Effects of Schistosoma 22.6 kDa/26 GST molecule mixed with Sepharose 4B beads on induction of CD4 + CD25 + regulatory T cells -RSB- .
22379972	0	CD4	80,83	CD25	72,76	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	8-Methoxypsoralen plus UVA treatment increases the proportion of CLA + CD25 + CD4 + T cells in lymph nodes of K5.hTGFb1 transgenic_mice .
22445281	0	CD4	134,137	CD25	138,142	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4 + CD25 + cells .
22451020	0	CD4	92,95	CD25	98,102	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The effect of various disease-modifying anti-rheumatic drugs on the suppressive function of CD4 CD25 regulatory T cells .
22457273	0	CD4	118,121	CD25	42,46	CD4	CD25	920	3559	Gene	Gene	repopulation|compound|START_ENTITY patients|nmod|repopulation cells|nmod|patients cells|nummod|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22502904	0	CD4	31,34	CD25	35,39	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-reg|compound|START_ENTITY T-reg|compound|END_ENTITY	Chimeric acceleration by donor CD4 + CD25 + T-reg depleted fraction in splenocyte transplantation .
22506556	0	CD4	32,35	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	depletion|nmod|START_ENTITY END_ENTITY|nsubj|depletion	In vitro selective depletion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T-cells from PBMC using anti-tac-SAP .
22521783	0	CD4	93,96	CD25	97,101	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Effect of transcatheter_renal_arterial_embolization combined with cryoablation on regulatory CD4 + CD25 + T lymphocytes in the peripheral blood of patients with advanced renal_carcinoma .
22552859	0	CD4	14,17	CD25	19,23	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + LAP + and CD4 + CD25 + Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE - / - mice .
22576630	0	CD4	103,106	CD25	107,111	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The sphingosine-1-phosphate receptor agonist FTY720 and its phosphorylated form affect the function of CD4 + CD25 + T cells in vitro .
22609353	0	CD4	60,63	CD25	68,72	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22613171	0	CD4	36,39	CD25	76,80	CD4	CD25	920	3559	Gene	Gene	function|compound|START_ENTITY restores|dobj|function restores|advcl|normalizing normalizing|xcomp|frequencies frequencies|nsubj|END_ENTITY	Opioid maintenance therapy restores CD4 + T cell function by normalizing CD4 + CD25 -LRB- high -RRB- regulatory T cell frequencies in heroin user .
22618267	0	CD4	84,87	CD25	88,92	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibition of osteoclast differentiation and matrix metalloproteinase production by CD4 + CD25 + T cells in mice .
22636320	0	CD4	82,85	CD25	86,90	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Monocyte-derived dendritic cells from breast_cancer patients are biased to induce CD4 + CD25 + Foxp3 + regulatory T cells .
22717168	0	CD4	39,42	CD25	43,47	CD4	CD25	101790140	101789606	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory T cell properties of thymic CD4 + CD25 + cells in ducks .
22727044	0	CD4	40,43	CD25	44,48	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Treatment with MOG-DNA vaccines induces CD4 + CD25 + FoxP3 + regulatory T cells and up-regulates genes with neuroprotective functions in experimental_autoimmune_encephalomyelitis .
22749980	0	CD4	12,15	CD25	16,20	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Neutrophil -- CD4 + CD25 + T regulatory cell interactions : a possible new mechanism of infectious tolerance .
22760780	0	CD4	20,23	CD25	24,28	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral_deficiency and thrombocytopenia in a murine model of immune_thrombocytopenia .
22783261	0	CD4	51,54	CD25	58,62	CD4	CD25	920	3559	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|amod|END_ENTITY	The development and immunosuppressive functions of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are under influence of the adenosine-A2A_adenosine_receptor pathway .
22791223	0	CD4	24,27	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Increased expression of CD4 + CD25 + FOXP3 + regulatory T cells correlates with Epstein-Barr_virus and has no impact on survival in patients with classical_Hodgkin_lymphoma in Brazil .
22793523	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY FoxP3|nummod|+ FoxP3|compound|END_ENTITY	The decreased CD4 + CD25 + FoxP3 + T cells in nonstimulated allergic_rhinitis patients sensitized to house dust mites .
22815292	0	CD4	45,48	CD25	49,53	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
22837649	0	CD4	34,37	CD25	40,44	CD4	CD25	920	3559	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|amod|END_ENTITY	Apoptosis Signaling Is Altered in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T Regulatory Lymphocytes in Pre-Eclampsia .
22851544	0	CD4	93,96	CD25	97,101	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Cytokine therapy with interleukin-2 / anti-interleukin-2 monoclonal antibody complexes expands CD4 + CD25 + Foxp3 + regulatory T cells and attenuates development and progression of atherosclerosis .
22860054	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + regulatory T cell depletion modulates anxiety and depression-like behaviors in mice .
22873180	0	CD4	113,116	CD25	117,121	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic_dermatitis via generation of CD4 + CD25 + Foxp3 + T cells .
22875869	0	CD4	0,3	CD25	5,9	CD4	CD25	920	3669	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + High Foxp3 + regulatory T cells , B lymphocytes , and T lymphocytes in patients with acute_ITP in Assiut Children Hospital .
22884251	0	CD4	33,36	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Removal of increased circulating CD4 + CD25 + Foxp3 + regulatory T cells in patients with septic_shock using hemoperfusion with polymyxin B-immobilized fibers .
22890368	0	CD4	80,83	CD25	84,88	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Patients with early-stage myelodysplastic_syndromes show increased frequency of CD4 + CD25 + CD127 -LRB- low -RRB- regulatory T cells .
22891289	0	CD4	124,127	CD25	101,105	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY CD25-FoxP3|nummod|+ Tregs|nmod|CD25-FoxP3 Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891289	0	CD4	97,100	CD25	101,105	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891772	0	CD4	44,47	CD25	80,84	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY conversion|nmod|CD25 modulates|dobj|conversion T|dep|modulates T|nmod|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22891772	0	CD4	71,74	CD25	53,57	CD4	CD25	920	3559	Gene	Gene	CD25|compound|START_ENTITY T|nmod|CD25 T|dep|modulates modulates|dobj|conversion conversion|nmod|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22939904	0	CD4	18,21	CD25	24,28	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|compound|END_ENTITY	In vitro-expanded CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells controls corneal allograft rejection .
22968996	0	CD4	49,52	CD25	56,60	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|amod|END_ENTITY	The role of dendritic cells in the generation of CD4 -LRB- + -RRB- CD25 -LRB- HI -RRB- Foxp3 -LRB- + -RRB- T cells induced by amino_acid copolymers .
22971347	0	CD4	33,36	CD25	39,43	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|compound|END_ENTITY	Plasmodium_chabaudi AS : distinct CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cell responses during infection in DBA/2 and BALB/c mice .
22984435	0	CD4	24,27	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Dendritic cells control CD4 + CD25 + Treg cell suppressor function in vitro through juxtacrine delivery of IL-2 .
23000301	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Treg derived from hepatocellular_carcinoma mice inhibits_tumor immunity .
23019018	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
23028916	0	CD4	110,113	CD25	100,104	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23028916	0	CD4	27,30	CD25	100,104	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY expansion|nmod|cells cells|amod|vitro vitro|advcl|inhibiting inhibiting|dobj|function function|nmod|T T|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23041608	0	CD4	119,122	CD25	123,127	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activation of the aryl_hydrocarbon_receptor reduces the number of precursor and effector T cells , but preserves thymic CD4 + CD25 + Foxp3 + regulatory T cells .
23085944	0	CD4	80,83	CD25	86,90	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY macrophages|nmod|mice Induction|nmod|macrophages END_ENTITY|nsubj|Induction	Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells .
23110942	0	CD4	44,47	CD25	50,54	CD4	CD25	920	3559	Gene	Gene	CD127|nummod|START_ENTITY CD127|compound|END_ENTITY	Impaired regulatory function in circulating CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- low / - -RRB- T cells in patients with myasthenia_gravis .
23121887	0	CD4	71,74	CD25	75,79	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Bee venom ameliorates ovalbumin induced allergic_asthma via modulating CD4 + CD25 + regulatory T cells in mice .
23161469	0	CD4	31,34	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
23173675	0	CD4	37,40	CD25	42,46	CD4	CD25	920	3669	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Quantitative reduction of peripheral CD4 + CD25 + FOXP3 + regulatory T cells in reproductive_failure after artificial_insemination_by_donor_sperm .
23178575	0	CD4	68,71	CD25	72,76	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Influence of anticancer agents on cell survival , proliferation , and CD4 + CD25 + Foxp3 + regulatory T cell-frequency in human peripheral-blood mononuclear cells activated by T cell-mitogen .
23185797	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Treg and TGF-beta play important roles in pathogenesis of Uygur cervical_carcinoma .
23198878	0	CD4	7,10	CD25	13,17	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine CD4 CD25 cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo .
23249428	0	CD4	59,62	CD25	63,67	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Lower proportions of CD4 + CD25 -LRB- high -RRB- and CD4 + FoxP3 , but not CD4 + CD25 + CD127 -LRB- low -RRB- FoxP3 + T cell levels in children with autoimmune_thyroid_diseases .
23267787	0	CD4	52,55	CD25	56,60	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Effect of rapamycin and interleukin-2 on regulatory CD4 + CD25 + Foxp3 + T cells in mice after allogenic corneal transplantation .
23280063	0	CD4	100,103	CD25	111,115	CD4	CD25	920	3559	Gene	Gene	CD45ro|compound|START_ENTITY expression|nmod|CD45ro enhances|dobj|expression +|dep|enhances +|dobj|CD127 CD127|compound|END_ENTITY	Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4 + CD45ro + CD25 + CD127 -LRB- low -RRB- regulatory T cells .
23282736	0	CD4	35,38	CD25	39,43	CD4	CD25	920	3559	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	The expression and significance of CD4 + CD25 + CD127low / - regulatory T cells and Foxp3 in patients with portal hypertension and hypersplenism .
23340699	0	CD4	8,11	CD25	14,18	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lack of CD4 CD25 FOXP3 regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki_disease .
23354908	0	CD4	32,35	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Decreased levels of circulating CD4 + CD25 + Foxp3 + regulatory T cells in patients with primary antiphospholipid_syndrome .
23450683	6	CD4	1269,1272	CD25	1273,1277	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Suppression assays showed that CD4 + CD25 -LRB- high -RRB- cells in patients with antibiotic-refractory arthritis did not effectively suppress proliferation of CD4 + CD25 - cells or secretion of interferon-y and tumor_necrosis_factor_a , whereas those cells in patients with antibiotic-responsive arthritis did suppress proliferation of CD4 + CD25 - cells and secretion of interferon-y and tumor_necrosis_factor_a .
23498798	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY +|nsubj|Induction +|dobj|cells cells|compound|END_ENTITY	Induction of CD4 + CD25 + T cells and control of cardiac allograft rejection by CD40/CD40L costimulatory pathway blockade in mice .
23502334	0	CD4	17,20	CD25	22,26	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Sclareol reduces CD4 + CD25 + FoxP3 + Treg cells in a breast_cancer model in vivo .
23509755	0	CD4	0,3	CD25	5,9	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + FOXP3 + Treg cells induced by rSSP4 derived from T. _ cruzi amastigotes increase parasitemia in an experimental Chagas_disease model .
23614243	0	CD4	22,25	CD25	28,32	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Relationship between CD4 + CD25 + Foxp3 + regulatory T cells and Th17 responses in Chlamydia muridarum pulmonary_infection -RSB- .
23623844	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Evaluation of CD4 + CD25 + FOXP3 + regulatory T cells function in patients with common variable immunodeficiency .
23628659	0	CD4	126,129	CD25	121,125	CD4	CD25	407098(Tax:9913)	281861(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro effects of meloxicam on the number , Foxp3 expression , production of selected cytokines , and apoptosis of bovine CD25 + CD4 + and CD25-CD4 + cells .
23635849	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells attenuate lipopolysaccharide-induced systemic inflammatory responses and promotes survival in murine Escherichia_coli infection .
23648818	0	CD4	142,145	CD25	146,150	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	numbers|compound|START_ENTITY numbers|compound|END_ENTITY	Bifidobacterium infantis suppression of Peyer 's patch MIP-1a and MIP-1b secretion during Salmonella infection correlates with increased local CD4 + CD25 + T cell numbers .
23650616	0	CD4	32,35	CD25	26,30	CD4	CD25	920	3559	Gene	Gene	proliferation|compound|START_ENTITY proliferation|compound|END_ENTITY	miR-142-3p is involved in CD25 + CD4 T cell proliferation by targeting the expression of glycoprotein_A_repetitions_predominant .
23664516	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells in the pathophysiology of immune thrombocytopenia .
23681433	0	CD4	14,17	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	time|compound|START_ENTITY time|compound|END_ENTITY	Evaluation of CD4 + CD25 + T lymphocyte response time kinetics in patients with chronic_Chagas_disease after in vitro stimulation with recombinant Trypanosoma_cruzi antigens .
23728588	0	CD4	44,47	CD25	48,52	CD4	CD25	920	3559	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Analysis of circulating regulatory T cells -LRB- CD4 + CD25 + CD127 - -RRB- after cryosurgery in prostate_cancer .
23734780	0	CD4	34,37	CD25	38,42	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
23749427	0	CD4	55,58	CD25	60,64	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
23760252	0	CD4	64,67	CD25	69,73	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Infection with feline_immunodeficiency_virus directly activates CD4 + CD25 + T regulatory cells .
23776439	0	CD4	19,22	CD25	25,29	CD4	CD25	920	3559	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|amod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
23813328	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells contribute in liver_fibrosis improvement with interferon_alpha .
23817221	0	CD4	28,31	CD25	32,36	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Frequency and activation of CD4 + CD25 FoxP3 + regulatory T cells in peripheral blood from children with atopic_allergy .
23830064	0	CD4	22,25	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD19 + CD23 + B cells , CD4 + CD25 + T cells , E-selectin and interleukin-12 levels in children with steroid sensitive nephrotic_syndrome .
23881298	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 regulatory T cells and vascular_dysfunction in hypertension .
23882125	0	CD4	77,80	CD25	82,86	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Disruption of TSC1/2 signaling complex reveals a checkpoint governing thymic CD4 + CD25 + Foxp3 + regulatory T-cell development in mice .
23883202	0	CD4	40,43	CD25	46,50	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Measurement of suppressor activity of T CD4 CD25 T reg cells using bromodeoxyuridine incorporation assay .
23883515	0	CD4	106,109	CD25	110,114	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The control of CD8 + T cell responses is preserved in perforin-deficient mice and released by depletion of CD4 + CD25 + regulatory T cells .
23884338	0	CD4	81,84	CD25	86,90	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4 + CD25 + Foxp3 + regulatory T cells in ischemia/reperfusion-induced acute kidney_injury .
23893806	0	CD4	37,40	CD25	41,45	CD4	CD25	920	3559	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Human mesenchymal stem cells elevate CD4 + CD25 + CD127low / - regulatory T cells of asthmatic patients via heme_oxygenase-1 .
23911408	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD25 + T regs with acetylated FoxP3 are associated with immune suppression in human leprosy .
23917832	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + T lymphocytes and regulation of the immune system : perspectives for a pathophysiological understanding of sepsis .
23949701	0	CD4	22,25	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute_respiratory_distress_syndrome is associated with increased 30-day mortality .
23964278	0	CD4	77,80	CD25	20,24	CD4	CD25	920	3559	Gene	Gene	Effectors|compound|START_ENTITY Stimulation|nmod|Effectors Induced|nmod|Stimulation T|dobj|Induced T|nsubj|Expression Expression|nmod|FOXP3 FOXP3|compound|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
23968847	0	CD4	45,48	CD25	50,54	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Influences of cerebral stent implantation on CD4 + CD25 + FOXP3 + Treg , Th1 and Th17 cells .
23971188	0	CD4	75,78	CD25	69,73	CD4	CD25	407098(Tax:9913)	281861(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dexamethasone , but not meloxicam , suppresses proliferation of bovine CD25 + CD4 + and CD25 - CD4 + T cells .
23971188	0	CD4	90,93	CD25	69,73	CD4	CD25	407098(Tax:9913)	281861(Tax:9913)	Gene	Gene	cells|compound|START_ENTITY proliferation|dep|cells proliferation|nmod|+ +|compound|END_ENTITY	Dexamethasone , but not meloxicam , suppresses proliferation of bovine CD25 + CD4 + and CD25 - CD4 + T cells .
24007829	0	CD4	1,4	CD25	5,9	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|dobj|numbers numbers|nummod|+ +|compound|END_ENTITY	-LSB- CD4 + CD25 + CD127low -LRB- Treg -RRB- cell numbers in patients with allergic_rhinitis with and without immunotherapy -RSB- .
24023916	0	CD4	13,16	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depletion of CD4 + CD25 + regulatory T cells promotes CCL21-mediated antitumor immunity .
24030387	0	CD4	62,65	CD25	66,70	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mast cells suppress murine GVHD in a mechanism independent of CD4 + CD25 + regulatory T cells .
24076465	0	CD4	32,35	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|compound|END_ENTITY	Human lung fibroblasts increase CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells in co-cultured CD4 -LRB- + -RRB- lymphocytes .
24076465	0	CD4	77,80	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	co-cultured|dep|START_ENTITY lymphocytes|amod|co-cultured cells|nmod|lymphocytes T|dobj|cells T|nsubj|Foxp3 Foxp3|compound|END_ENTITY	Human lung fibroblasts increase CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells in co-cultured CD4 -LRB- + -RRB- lymphocytes .
24076591	0	CD4	48,51	CD25	52,56	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Arteether exerts antitumor activity and reduces CD4 + CD25 + FOXP3 + T-reg cells in vivo .
24119152	0	CD4	13,16	CD25	17,21	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	IFN-y blocks CD4 + CD25 + Tregs and abolishes immune privilege of minor histocompatibility mismatched corneal allografts .
24134738	0	CD4	115,118	CD25	7,11	CD4	CD25	920	3559	Gene	Gene	expression|nmod|START_ENTITY suppress|dobj|expression protein|acl:relcl|suppress forkhead|dobj|protein forkhead|nsubj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- forkhead box protein 3 -LRB- + -RRB- regulatory T lymphocytes suppress interferon-y and CD107 expression in CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells from tuberculous_pleural_effusions .
24135451	0	CD4	23,26	CD25	27,31	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An increased number of CD4 + CD25 + cells induced by an oral administration of Lactobacillus_plantarum NRIC0380 are involved in antiallergic activity .
24177275	0	CD4	118,121	CD25	123,127	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	APL-1 , an altered peptide ligand derived from human heat-shock protein 60 , selectively induces apoptosis in activated CD4 + CD25 + T cells from peripheral blood of rheumatoid_arthritis patients .
24214631	0	CD4	38,41	CD25	44,48	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	FoxP3 provides competitive fitness to CD4 CD25 T cells in leprosy patients via transcriptional regulation .
24244610	0	CD4	30,33	CD25	34,38	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24294847	0	CD4	40,43	CD25	47,51	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|dobj|cells cells|nummod|END_ENTITY	-LSB- Apoptosis and its mechanisms of spleen CD4 CD25 regulatory T cells in severe aplastic_anemiamouse model -RSB- .
24339053	0	CD4	140,143	CD25	145,149	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
24345703	0	CD4	11,14	CD25	15,19	CD4	CD25	920	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes of CD4 + CD25 + FOXP3 + and CD8 + CD28 - regulatory T cells in non-small_cell_lung_cancer patients undergoing surgery .
24348676	0	CD4	71,74	CD25	75,79	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Decreased CD127 expression on CD4 + T-cells and elevated frequencies of CD4 + CD25 + CD127 - T-cells in children with long-lasting type_1_diabetes .
24366217	0	CD4	156,159	CD25	162,166	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin _ D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4 CD25 Foxp3 regulatory T cells .
24368924	0	CD4	34,37	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An imbalance between frequency of CD4 + CD25 + FOXP3 + regulatory T cells and CCR4 + and CCR9 + circulating helper T cells is associated with active perennial allergic_conjunctivitis .
24405386	0	CD4	59,62	CD25	63,67	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Human adipose-derived stromal/stem cells induce functional CD4 + CD25 + FoxP3 + CD127 - regulatory T cells under low oxygen culture conditions .
24452947	0	CD4	33,36	CD25	38,42	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24454972	0	CD4	28,31	CD25	34,38	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
24476849	0	CD4	18,21	CD25	22,26	CD4	CD25	403931(Tax:9615)	403870(Tax:9615)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Serial changes of CD4 + CD25 + FoxP3 + regulatory T cell in canine model of sepsis induced by endotoxin .
24557710	0	CD4	128,131	CD25	132,136	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Narrowband ultraviolet B phototherapy ameliorates acute_graft-versus-host_disease by a mechanism involving in vivo expansion of CD4 + CD25 + Foxp3 + regulatory T cells .
24617046	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells and MMP-9 as diagnostic salivary biomarkers in oral_lichen_planus .
24646790	0	CD4	29,32	CD25	33,37	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Clinical prognostic value of CD4 + CD25 + FOXP3 + regulatory T cells in peripheral blood of Barcelona Clinic Liver_Cancer -LRB- BCLC -RRB- stage B_hepatocellular_carcinoma patients .
24702146	0	CD4	49,52	CD25	53,57	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cardiac allograft tolerance induced by isogeneic CD4 + CD25 + regulatory T cells .
24752698	0	CD4	23,26	CD25	30,34	CD4	CD25	920	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
24797972	0	CD4	63,66	CD25	69,73	CD4	CD25	920	3559	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
24901172	0	CD4	31,34	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	The variation of expression of CD4 + CD25 + Foxp3 + regulatory T cells in patients with Helicobacter_pylori_infection and eradication .
24904415	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
25030097	0	CD4	49,52	CD25	55,59	CD4	CD25	920	3559	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Comment on Adamzik et al. : An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory_distress_syndrome is associated with increased 30-day mortality .
25054604	0	CD4	121,124	CD25	127,131	CD4	CD25	920	3559	Gene	Gene	Treg|nummod|START_ENTITY Treg|compound|END_ENTITY	Patients with systemic_lupus_erythematosus and secondary_antiphospholipid_syndrome have decreased numbers of circulating CD4 CD25 Foxp3 Treg and CD3 CD19 B cells .
25110149	0	CD4	40,43	CD25	44,48	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Cerebral_ischemia increases bone marrow CD4 + CD25 + FoxP3 + regulatory T cells in mice via signals from sympathetic nervous system .
25202951	0	CD4	62,65	CD25	68,72	CD4	CD25	920	3559	Gene	Gene	amplification|nmod|START_ENTITY Isolation|appos|amplification END_ENTITY|nsubj|Isolation	-LSB- Isolation , amplification and identification of human natural CD4 CD25 regulatory T cells in vitro -RSB- .
25205548	0	CD4	30,33	CD25	36,40	CD4	CD25	920	3559	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Increase in the Expression of CD4 + CD25 + Lymphocytic T Cells in the Indeterminate Clinical Form of Human Chagas Disease After Stimulation With Recombinant Antigens of Trypanosoma_cruzi .
25256257	0	CD4	42,45	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY Expansion|dep|cells Expansion|nmod|/ /|compound|END_ENTITY	Expansion of regulatory GITR + CD25 Low / - CD4 + T cells in systemic_lupus_erythematosus patients .
25293774	0	CD4	0,3	CD25	104,108	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY invariant|nsubj|+ GVHD|dep|invariant GVHD|nmod|expansion expansion|nmod|+ +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25293774	0	CD4	100,103	CD25	104,108	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25311400	0	CD4	21,24	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Circulating level of CD4 + CD25 + FOXP3 + T cells in patients with chronic_urticaria .
25480168	0	CD4	28,31	CD25	0,4	CD4	CD25	920	3559	Gene	Gene	TIL|compound|START_ENTITY subset|nmod|TIL identifies|dobj|subset identifies|nsubj|END_ENTITY	CD25 identifies a subset of CD4 FoxP3 TIL that are exhausted yet prognostically favorable in human ovarian_cancer .
25485946	0	CD4	30,33	CD25	96,100	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|Expression Expression|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
25510094	0	CD4	37,40	CD25	41,45	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Studying the dynamics of the levels CD4 + CD25 + , CD4 + HLA-DR4 + and CD4 + CD95 + cells in the semen of men with oligosymptomatic forms of chronic urogenital_infection complicated infertility under the influence of fortege -RSB- .
25523632	0	CD4	17,20	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Extension|nmod|Foxp3 END_ENTITY|nsubj|Extension	Extension of the CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- CD25 -LRB- - / low -RRB- regulatory T-cell subpopulation in type_1_diabetes_mellitus .
25539460	0	CD4	28,31	CD25	11,15	CD4	CD25	920	3559	Gene	Gene	CD25hiCD127|compound|START_ENTITY +|dep|CD25hiCD127 END_ENTITY|dep|+	CD4 + CD45RO + CD25 - / lowCD127 + : CD4 + CD45RO + CD25hiCD127 - / low Ratio in Peripheral Blood_colon ; A Useful Biomarker to Detect Cardiac_Allograft_Vasculopathy in Heart Transplanted Patients .
25595257	0	CD4	91,94	CD25	95,99	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4 + CD25 + Foxp3 + T cells -LRB- Tregs -RRB- in a mouse study for active DNA Ab42 immunotherapy .
25742430	0	CD4	94,97	CD25	99,103	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Nicotine Ameliorates Experimental Severe Acute Pancreatitis via Enhancing Immunoregulation of CD4 + CD25 + Regulatory T Cells .
25767469	0	CD4	0,3	CD25	4,8	CD4	CD25	920	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	CD4 + CD25 + CD127 -LRB- low -RRB- Regulatory T Cells Play Predominant Anti-Tumor Suppressive Role in Hepatitis_B_Virus-Associated Hepatocellular_Carcinoma .
25790134	0	CD4	46,49	CD25	50,54	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
25803101	0	CD4	11,14	CD25	15,19	CD4	CD25	395362(Tax:9031)	3559	Gene	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Changes of CD4 + CD25 + Cells Ratio in Immune Organs from Chickens Challenged with Infectious_Bursal_Disease_Virus Strains with Varying Virulences .
25833958	0	CD4	102,105	CD25	106,110	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4 + CD25 + FoxP3 + Treg .
25854343	0	CD4	14,17	CD25	18,22	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Inhibit|compound|START_ENTITY Inhibit|compound|END_ENTITY	Tumor-derived CD4 + CD25 + Tregs Inhibit the Maturation and Antigen-Presenting Function of Dendritic Cells .
25862675	0	CD4	20,23	CD25	24,28	CD4	CD25	920	3559	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	F protein increases CD4 + CD25 + T cell population in patients with chronic hepatitis_C .
25945787	0	CD4	31,34	CD25	35,39	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Peripheral Dendritic Cells and CD4 + CD25 + Foxp3 + Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage .
25945787	0	CD4	31,34	CD25	35,39	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Peripheral Dendritic Cells and CD4 + CD25 + Foxp3 + Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage .
25950023	0	CD4	127,130	CD25	131,135	CD4	CD25	403931(Tax:9615)	403870(Tax:9615)	Gene	Gene	CELLS|compound|START_ENTITY CELLS|compound|END_ENTITY	EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4 + CD25 + FOXP3 + REGULATORY T CELLS .
25955764	0	CD4	55,58	CD25	60,64	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Molecule|compound|START_ENTITY Molecule|compound|END_ENTITY	Deletion of Fibrinogen-like Protein 2 -LRB- FGL-2 -RRB- , a Novel CD4 + CD25 + Treg Effector Molecule , Leads to Improved Control of Echinococcus_multilocularis_Infection in Mice .
25967708	0	CD4	21,24	CD25	25,29	CD4	CD25	920	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Relationship between CD4 + CD25 + Treg and expression of HIF-1a and Ki-67 in NSCLC patients .
25969837	0	CD4	23,26	CD25	28,32	CD4	CD25	920	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Increased Frequency of CD4 + CD25 + FoxP3 + T Regulatory Cells in Pulmonary_Tuberculosis Patients Undergoing Specific Treatment and Its Relationship with Their Immune-Endocrine Profile .
25969999	1	CD4	59,62	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	1-induced CD4 + CD25 + regulatory T cells prevents immune response-mediated spontaneous_abortion .
26034548	0	CD4	14,17	CD25	19,23	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Evaluation of CD4 + CD25 + FoxP3 + Regulatory T cells and FoxP3 and CTLA-4 gene Expression in Patients wwith Newly Diagnosed Tuberculosis in Northeast of Iran .
26063731	0	CD4	48,51	CD25	52,56	CD4	CD25	920	3559	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26067079	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Natural|compound|START_ENTITY Natural|compound|END_ENTITY	CD4 + CD25 + Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis_B_Virus Transgenic_Mice via Membrane-Bound TGF-b and OX40 .
26105222	1	CD4	44,47	CD25	50,54	CD4	CD25	920	3559	Gene	Gene	altered|nmod|START_ENTITY apoptosis|ccomp|altered FOXP3|amod|apoptosis FOXP3|compound|END_ENTITY	The apoptosis markers are altered in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T regulatorylymphocytes in pre-eclampsia .
26117939	0	CD4	12,15	CD25	18,22	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	-LSB- Changes of CD4 + CD25 + Foxp3 + regulatory T cells in the peripheral blood and their correlation with insulin resistance in different stages of prostate_cancer -RSB- .
26166019	0	CD4	36,39	CD25	40,44	CD4	CD25	920	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26226256	0	CD4	51,54	CD25	55,59	CD4	CD25	920	3559	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Assessment of the frequency of regulatory T cells -LRB- CD4 + CD25 + CD127 - -RRB- in children with hemophilia_A : relation to factor_VIII inhibitors and disease severity .
26266813	0	CD4	23,26	CD25	27,31	CD4	CD25	920	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Expression of PD-L1 on CD4 + CD25 + Foxp3 + Regulatory T Cells of Patients with Chronic_HBV_Infection and Its Correlation with Clinical Parameters .
26273136	0	CD4	29,32	CD25	35,39	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
26355564	0	CD4	94,97	CD25	100,104	CD4	CD25	920	3669	Gene	Gene	Foxp3|nummod|START_ENTITY Foxp3|compound|END_ENTITY	Overexpression of CD45RA isoforms in carriers of the C77G mutation leads to hyporeactivity of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
26452441	0	CD4	59,62	CD25	63,67	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intranasal Immunization with Heat_Shock_Protein_60 Induces CD4 + CD25 + GARP + and Type-1 Regulatory T Cells and Inhibits Early Atherosclerosis .
26517875	0	CD4	26,29	CD25	31,35	CD4	CD25	920	3559	Gene	Gene	Controlled|compound|START_ENTITY Controlled|compound|END_ENTITY	Orally-Induced Intestinal CD4 + CD25 + FoxP3 + Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic_Reactions .
26550650	0	CD4	90,93	CD25	94,98	CD4	CD25	920	3559	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	-LSB- CDR3 spectratyping analysis and complementary decision area 3 sequence determination for CD4 + CD25 + Tregs in patients with chronic hepatitis_B -RSB- .
26553468	0	CD4	15,18	CD25	66,70	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	responses|nummod|START_ENTITY responses|nmod|Foxp3 Foxp3|compound|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26553468	0	CD4	62,65	CD25	66,70	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26590312	0	CD4	13,16	CD25	87,91	CD4	CD25	920	3559	Gene	Gene	+|nsubj|START_ENTITY +|nmod|Cells Cells|compound|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
26590312	0	CD4	83,86	CD25	87,91	CD4	CD25	920	3559	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
26693907	0	CD4	19,22	CD25	23,27	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Freeze and Thaw of CD4 + CD25 + Foxp3 + Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host_Disease .
26721345	0	CD4	58,61	CD25	22,26	CD4	CD25	920	3559	Gene	Gene	cell|compound|START_ENTITY expression|nmod|cell expression|compound|END_ENTITY	Enhanced pretreatment CD25 expression on peripheral blood CD4 + T cell predicts shortened survival in acute_myeloid_leukemia patients receiving induction chemotherapy .
26728371	0	CD4	94,97	CD25	119,123	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY differentiation|nmod|T Depressive|dep|differentiation Depressive|dep|cells cells|nmod|END_ENTITY	-LSB- Depressive effect of cigarette_smoke_extracts on dendritic cells inducing differentiation of CD4 -LRB- + -RRB- T cells into CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Tregs -RSB- .
26774852	0	CD4	125,128	CD25	131,135	CD4	CD25	920	3559	Gene	Gene	vitro|nmod|START_ENTITY CD45RA|amod|vitro CD45RA|compound|END_ENTITY	Human umbilical cord-derived mesenchymal stem cells suppress proliferation of PHA-activated lymphocytes in vitro by inducing CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD45RA -LRB- + -RRB- regulatory T cell production and modulating cytokine secretion .
26829554	0	CD4	33,36	CD25	37,41	CD4	CD25	920	3559	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
26955441	0	CD4	73,76	CD25	78,82	CD4	CD25	920	3559	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	The potential role of cell surface complement regulators and circulating CD4 + CD25 + T-cells in the development of autoimmune_myasthenia_gravis .
27049955	0	CD4	78,81	CD25	82,86	CD4	CD25	920	3559	Gene	Gene	Suppression|compound|START_ENTITY Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27070362	0	CD4	65,68	CD25	69,73	CD4	CD25	920	3559	Gene	Gene	CD127low|compound|START_ENTITY CD127low|compound|END_ENTITY	-LSB- The treatment by expanded ex vivo autologous regulatory T-cells CD4 + CD25 + FoxP3 + CD127low restores the balance of immune system in patients with remitting-relapsing multiple_sclerosis -RSB- .
7539635	0	CD4	48,51	CD25	72,76	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY expressing|nsubj|cells expressing|dobj|END_ENTITY	Influence of FK_506 -LRB- tacrolimus -RRB- on circulating CD4 + T cells expressing CD25 and CD45RA antigens in 19 patients with chronic_progressive_multiple_sclerosis participating in an open label drug safety trial .
7902998	0	CD4	90,93	CD25	66,70	CD4	CD25	920	3559	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells activation|appos|END_ENTITY	Gluten stimulation of coeliac mucosa in vitro induces activation -LRB- CD25 -RRB- of lamina propria CD4 + T cells and macrophages but no crypt-cell hyperplasia .
8094672	0	CD4	85,88	CD25	76,80	CD4	CD25	920	3559	Gene	Gene	cells|nummod|START_ENTITY activation|nmod|cells activation|appos|END_ENTITY	Activated T lymphocytes in the celiac lesion : non-proliferative activation -LRB- CD25 -RRB- of CD4 + alpha/beta cells in the lamina propria but proliferation -LRB- Ki-67 -RRB- of alpha/beta and gamma/delta cells in the epithelium .
8255102	0	CD4	34,37	CD25	44,48	CD4	CD25	920	3559	Gene	Gene	START_ENTITY|dep|CD71 CD71|compound|END_ENTITY	Soluble CD23 and other receptors -LRB- CD4 , CD8 , CD25 , CD71 -RRB- in serum of patients with chronic_lymphocytic_leukemia .
9176107	0	CD4	61,64	CD25	82,86	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD3|compound|START_ENTITY proliferation|nmod|CD3 inhibit|dobj|proliferation inhibit|parataxis|thymocytes thymocytes|nsubj|+ +|compound|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
9670041	0	CD4	0,3	CD25	4,8	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin_2 production .
9885918	0	CD4	46,49	CD25	41,45	CD4	CD25	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immunologic self-tolerance maintained by CD25 + CD4 + naturally anergic and suppressive T cells : induction of autoimmune_disease by breaking their anergic/suppressive state .
10899322	0	CD4	96,99	CD26	63,67	CD4	CD26	920	1803	Gene	Gene	modulated|nmod|START_ENTITY mechanism|acl|modulated END_ENTITY|nmod|mechanism	The HIV-1 gp120 inhibits the binding of adenosine_deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression .
16197392	0	CD4	47,50	CD26	11,15	CD4	CD26	920	1803	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|nummod|END_ENTITY	Absence of CD26 expression on skin-homing CLA + CD4 + T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with S __ zary_syndrome .
16320722	0	CD4	7,10	CD26	0,4	CD4	CD26	920	1803	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	CD26 + CD4 + T cell counts and attack risk in interferon-treated multiple_sclerosis .
17081623	0	CD4	0,3	CD26	32,36	CD4	CD26	920	1803	Gene	Gene	cells|compound|START_ENTITY cells|nmod|expression expression|compound|END_ENTITY	CD4 -LRB- + -RRB- memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple_sclerosis .
18460019	0	CD4	19,22	CD26	0,4	CD4	CD26	920	1803	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	CD26 expression on CD4 + T cells in patients with cutaneous_leishmaniasis .
21887518	0	CD4	105,108	CD26	139,143	CD4	CD26	920	1803	Gene	Gene	+|compound|START_ENTITY differentiated|nmod|+ differentiated|xcomp|expressing expressing|dobj|END_ENTITY	Altered proportions of na ve , central_memory and terminally differentiated central_memory subsets among CD4 + and CD8 + T cells expressing CD26 in patients with type 1 diabetes .
22252752	0	CD4	171,174	CD26	132,136	CD4	CD26	920	1803	Gene	Gene	+|compound|START_ENTITY markers|nmod|+ expression|appos|markers expression|appos|+ +|compound|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
24627194	0	CD4	15,18	CD26	21,25	CD4	CD26	920	1803	Gene	Gene	CD38|amod|START_ENTITY CD38|compound|END_ENTITY	Flow cytometry CD4 -LRB- + -RRB- CD26 -LRB- - -RRB- CD38 -LRB- + -RRB- lymphocyte subset in the microenvironment of Hodgkin_lymphoma-affected lymph nodes .
25786689	0	CD4	64,67	CD26	59,63	CD4	CD26	920	1803	Gene	Gene	T|compound|START_ENTITY T|amod|pulmonary_graft-versus-host_disease pulmonary_graft-versus-host_disease|nmod|END_ENTITY	Regulation of pulmonary_graft-versus-host_disease by IL-26 + CD26 + CD4 T lymphocytes .
7665988	0	CD4	17,20	CD26	47,51	CD4	CD26	920	1803	Gene	Gene	+|compound|START_ENTITY Costimulation|nmod|+ +|nsubj|Costimulation +|nmod|END_ENTITY	Costimulation of CD4 + and CD8 + T cells through CD26 : the ADA-binding epitope is not essential for complete signaling .
7903479	0	CD4	67,70	CD26	27,31	CD4	CD26	920	1803	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ HIV|nmod|cells entry|nmod|HIV cofactor|nmod|entry antigen|nmod|cofactor antigen|appos|END_ENTITY	T cell activation antigen , CD26 , as a cofactor for entry of HIV in CD4 + cells .
8806567	0	CD4	109,112	CD26	101,105	CD4	CD26	920	1803	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	HIV envelope glycoprotein-induced cell killing by apoptosis is enhanced with increased expression of CD26 in CD4 + T cells .
9183643	0	CD4	17,20	CD26	8,12	CD4	CD26	920	1803	Gene	Gene	memory|compound|START_ENTITY END_ENTITY|nmod|memory	Role of CD26 for CD4 memory T cell function and activation .
9729533	0	CD4	36,39	CD26	28,32	CD4	CD26	920	1803	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Low relative frequencies of CD26 -LRB- + -RRB- CD4 -LRB- + -RRB- cells in long-term nonprogressing human_immunodeficiency_virus_type_1-infected subjects .
1348033	0	CD4	44,47	CD27	4,8	CD4	CD27	920	939	Gene	Gene	lymphocytes|compound|START_ENTITY subset|nmod|lymphocytes contains|nsubj|subset END_ENTITY|parataxis|contains	The CD27 - subset of peripheral blood memory CD4 + lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo .
1358967	0	CD4	98,101	CD27	0,4	CD4	CD27	920	939	Gene	Gene	clones|compound|START_ENTITY expressed|nmod|clones expressed|nsubjpass|END_ENTITY	CD27 , a member of the nerve growth factor receptor family , is preferentially expressed on CD45RA + CD4 T cell clones and involved in distinct immunoregulatory functions .
14984597	0	CD4	143,146	CD27	98,102	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY regulated|nsubjpass|cells naive|acl:relcl|regulated changes|nmod|naive changes|nmod|expression expression|nmod|END_ENTITY	Automatic generation of lymphocyte heterogeneity : Division-dependent changes in the expression of CD27 , CCR7 and CD45 by activated human naive CD4 + T cells are independently regulated .
15500623	0	CD4	6,9	CD27	0,4	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY define|nsubj|cells END_ENTITY|parataxis|define	CD27 - CD4 + memory T cells define a differentiated memory population at both the functional and transcriptional levels .
16210336	0	CD4	89,92	CD27	67,71	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells subset|compound|END_ENTITY	Rapamycin , and not cyclosporin_A , preserves the highly suppressive CD27 + subset of human CD4 + CD25 + regulatory T cells .
17118766	0	CD4	33,36	CD27	14,18	CD4	CD27	920	939	Gene	Gene	T-lymphocytes|compound|START_ENTITY END_ENTITY|nmod|T-lymphocytes	Expression of CD27 on peripheral CD4 + T-lymphocytes correlates with the development of severe acute_graft-versus-host_disease after allogeneic bone marrow transplantation .
17425604	0	CD4	116,119	CD27	0,4	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells discriminates|nmod|expansion discriminates|nsubj|expression expression|compound|END_ENTITY	CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4 + CD25 + cells .
17453966	0	CD4	23,26	CD27	38,42	CD4	CD27	920	939	Gene	Gene	CD25|compound|START_ENTITY enriches|nmod|CD25 enriches|dobj|Foxp3 Foxp3|compound|END_ENTITY	Rapamycin enriches for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD27 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple_sclerosis .
18182812	0	CD4	29,32	CD27	83,87	CD4	CD27	920	939	Gene	Gene	subsets|nummod|START_ENTITY subsets|dep|analysis analysis|nummod|END_ENTITY	Heterogeneity of circulating CD4 + memory T-cell subsets in erythrodermic patients : CD27 analysis can help to distinguish cutaneous_T-cell_lymphomas from inflammatory erythroderma .
18506879	0	CD4	0,3	CD27	57,61	CD4	CD27	920	939	Gene	Gene	help|compound|START_ENTITY improves|nsubj|help improves|dobj|memory memory|nmod|expression expression|compound|END_ENTITY	CD4 + T cell help improves CD8 + T cell memory by retained CD27 expression .
18606659	0	CD4	15,18	CD27	0,4	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY instructs|dobj|cells instructs|nsubj|END_ENTITY	CD27 instructs CD4 + T cells to provide help for the memory CD8 + T cell response after protein immunization .
19454729	0	CD4	19,22	CD27	0,4	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD27 expression on CD4 + T cells differentiates effector from regulatory T cell subsets in the lung .
21214539	0	CD4	83,86	CD27	94,98	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cytomegalovirus_infection induces the accumulation of short-lived , multifunctional CD4 + CD45RA + CD27 + T cells : the potential involvement of interleukin-7 in this process .
21220773	0	CD4	14,17	CD27	59,63	CD4	CD27	920	939	Gene	Gene	numbers|compound|START_ENTITY numbers|nmod|END_ENTITY	Reduced naive CD4 T cell numbers and impaired induction of CD27 in response to T cell receptor stimulation reflect a state of immune activation in chronic_hepatitis_C_virus_infection .
24391889	0	CD4	106,109	CD27	7,11	CD4	CD27	920	939	Gene	Gene	recovery|compound|START_ENTITY predict|dobj|recovery predict|nsubj|percentages percentages|compound|END_ENTITY	Higher CD27 + CD8 + T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4 + T cell recovery in treated HIV_infection .
26818544	0	CD4	0,3	CD27	28,32	CD4	CD27	920	939	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ activate|nsubj|cells activate|dobj|cells cells|compound|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
27020860	0	CD4	46,49	CD27	0,4	CD4	CD27	404704(Tax:9823)	100520023	Gene	Gene	help|compound|START_ENTITY recapitulates|dobj|help recapitulates|nsubj|agonism agonism|compound|END_ENTITY	CD27 agonism plus PD-1 blockade recapitulates CD4 + T cell help in therapeutic anti-cancer vaccination .
7923389	0	CD4	57,60	CD27	27,31	CD4	CD27	920	939	Gene	Gene	cells|compound|START_ENTITY subsets|nmod|cells regulation|nmod|subsets regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of CD27 expression on subsets of CD4 T cells .
10458758	0	CD4	83,86	CD28	0,4	CD4	CD28	920	940	Gene	Gene	expression|nmod|START_ENTITY down-regulation|nmod|expression results|nmod|down-regulation results|nummod|END_ENTITY	CD28 co-stimulation results in down-regulation of lymphotactin expression in human CD4 -LRB- + -RRB- but not CD8 -LRB- + -RRB- T cells via an IL-2-dependent mechanism .
10798745	0	CD4	26,29	CD28	63,67	CD4	CD28	920	940	Gene	Gene	anergy|compound|START_ENTITY Induction|nmod|anergy Induction|nmod|END_ENTITY	Induction of xenoreactive CD4 + T-cell anergy by suppressor CD8 + CD28 - T cells .
10925251	0	CD4	130,133	CD28	99,103	CD4	CD28	920	940	Gene	Gene	lymphocytes|compound|START_ENTITY receptor|nmod|lymphocytes receptor|compound|END_ENTITY	The NF-kappa_B cascade is important in Bcl-xL expression and for the anti-apoptotic effects of the CD28 receptor in primary human CD4 + lymphocytes .
11120881	0	CD4	116,119	CD28	77,81	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY anergy|nmod|cells promotes|dobj|anergy promotes|nsubj|Costimulation Costimulation|nmod|ligation ligation|amod|lymphocyte_function-associated_antigen_1 lymphocyte_function-associated_antigen_1|nmod|absence absence|nmod|END_ENTITY	Costimulation via lymphocyte_function-associated_antigen_1 in the absence of CD28 ligation promotes anergy of naive CD4 + T cells .
11243699	0	CD4	140,143	CD28	91,95	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	thymocytes|compound|START_ENTITY deletion|nmod|thymocytes END_ENTITY|nmod|deletion	The affinity/avidity and length of exposure to the deleting ligand determine dependence on CD28 for the efficient deletion of self-specific CD4 + CD8 + thymocytes .
11318597	0	CD4	37,40	CD28	13,17	CD4	CD28	920	940	Gene	Gene	subsets|compound|START_ENTITY define|dobj|subsets define|nsubj|levels levels|compound|END_ENTITY	Cell surface CD28 levels define four CD4 + T cell subsets : abnormal expression in rheumatoid_arthritis .
11714791	0	CD4	8,11	CD28	59,63	CD4	CD28	404704(Tax:9823)	100738615	Gene	Gene	help|compound|START_ENTITY requires|nmod|help requires|dobj|costimulation costimulation|nummod|END_ENTITY	Without CD4 help , CD8 rejection of pig xenografts requires CD28 costimulation but not perforin killing .
12444145	0	CD4	62,65	CD28	51,55	CD4	CD28	920	940	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
12506015	0	CD4	23,26	CD28	0,4	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY loss|nmod|cells loss|nummod|END_ENTITY	CD28 loss in senescent CD4 + T cells : reversal by interleukin-12 stimulation .
12586604	0	CD4	108,111	CD28	0,4	CD4	CD28	920	940	Gene	Gene	T|compound|START_ENTITY proliferation|nmod|T transforming_growth_factor-beta1|nmod|proliferation cells|amod|transforming_growth_factor-beta1 effect|nmod|cells regulates|dobj|effect regulates|nsubj|co-stimulation co-stimulation|compound|END_ENTITY	CD28 co-stimulation regulates the effect of transforming_growth_factor-beta1 on the proliferation of na ve CD4 + T cells .
12751030	0	CD4	15,18	CD28	19,23	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A low level of CD4 + CD28 + T cells is an independent predictor of high mortality in human_immunodeficiency_virus_type_1-infected patients .
1363054	0	CD4	52,55	CD28	26,30	CD4	CD28	920	940	Gene	Gene	T|compound|START_ENTITY activation|nmod|T END_ENTITY|nmod|activation	A co-stimulatory role for CD28 in the activation of CD4 + T lymphocytes by staphylococcal_enterotoxin_B .
14500627	0	CD4	54,57	CD28	14,18	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY homeostasis|nmod|cells controls|dobj|homeostasis controls|nsubj|END_ENTITY	Cutting edge : CD28 controls peripheral homeostasis of CD4 + CD25 + regulatory T cells .
14502004	0	CD4	45,48	CD28	39,43	CD4	CD28	920	940	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Nadir CD4 + T-cell count and numbers of CD28 + CD4 + T-cells predict functional responses to immunizations in chronic_HIV-1_infection .
14609212	0	CD4	62,65	CD28	12,16	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells role|nmod|END_ENTITY	The role of CD28 and CTLA4 in the function and homeostasis of CD4 + CD25 + regulatory T cells .
14980436	0	CD4	115,118	CD28	0,4	CD4	CD28	920	940	Gene	Gene	detection|nmod|START_ENTITY assay|nmod|detection sensitivity|nmod|assay enhances|dobj|sensitivity enhances|nsubj|costimulation costimulation|compound|END_ENTITY	CD28 costimulation enhances the sensitivity of the ELISPOT assay for detection of antigen-specific memory effector CD4 and CD8 cell populations in human diseases .
15016653	0	CD4	86,89	CD28	0,4	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells inflammation|nmod|suppression exacerbates|dobj|inflammation exacerbates|nsubj|disruption disruption|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15048719	0	CD4	103,106	CD28	192,196	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells proliferation|nmod|mechanism mechanism|acl:relcl|involve involve|dobj|expression expression|nmod|ligands ligands|nummod|END_ENTITY	IL-1 acts on antigen-presenting cells to enhance the in vivo proliferation of antigen-stimulated naive CD4 T cells via a CD28-dependent mechanism that does not involve increased expression of CD28 ligands .
15142043	0	CD4	29,32	CD28	23,27	CD4	CD28	920	940	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ follow|parataxis|T follow|nmod|END_ENTITY	Long time follow up of CD28 - CD4 + T cells in living kidney transplant patients .
15356139	0	CD4	56,59	CD28	11,15	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells role|nmod|END_ENTITY	A role for CD28 in lymphopenia-induced_proliferation of CD4 T cells .
15488732	0	CD4	67,70	CD28	0,4	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	+|compound|START_ENTITY required|nmod|+ required|nsubjpass|END_ENTITY	CD28 is required for T cell activation and IFN-gamma production by CD4 + and CD8 + T cells in response to Trypanosoma_cruzi_infection .
15568615	0	CD4	71,74	CD28	24,28	CD4	CD28	920	940	Gene	Gene	+|compound|START_ENTITY costimulation|nmod|+ costimulation|nsubj|effects effects|nmod|END_ENTITY	Differential effects of CD28 costimulation upon cytokine production by CD4 + and CD8 + T cells .
16011533	0	CD4	47,50	CD28	17,21	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nsubj|Dysregulation Dysregulation|nmod|END_ENTITY	Dysregulation of CD28 and CTLA-4 expression by CD4 T cells from previously immunodeficient HIV-infected patients with sustained virological responses to highly active antiretroviral therapy .
16137665	0	CD4	85,88	CD28	0,4	CD4	CD28	920	940	Gene	Gene	cells|nummod|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	CD28 regulates glucocorticoid-induced TNF receptor family-related gene expression on CD4 + T cells via IL-2-dependent mechanisms .
16338210	0	CD4	76,79	CD28	0,4	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY put|nmod|cells put|nsubj|superagonists superagonists|compound|END_ENTITY	CD28 superagonists put a break on autoimmunity by preferentially activating CD4 + CD25 + regulatory T cells .
16339520	0	CD4	119,122	CD28	12,16	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY polarization|nmod|cells induces|dobj|polarization induces|nsubj|Ligation Ligation|nmod|END_ENTITY	Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells .
16406844	0	CD4	63,66	CD28	90,94	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Ex vivo expansion of dendritic-cell-activated antigen-specific CD4 + T cells with anti-CD3 / CD28 , interleukin-7 , and interleukin-15 : potential for adoptive T cell immunotherapy .
16600196	0	CD4	89,92	CD28	0,4	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY memory|nmod|cells induction|nmod|memory required|nmod|induction required|nsubjpass|END_ENTITY	CD28 is required for induction and maintenance of immunological memory in toxin-reactive CD4 + T cells in vivo .
16828835	0	CD4	21,24	CD28	52,56	CD4	CD28	24932(Tax:10116)	25660(Tax:10116)	Gene	Gene	cells|nummod|START_ENTITY develop|nsubj|cells develop|dobj|responsiveness responsiveness|compound|END_ENTITY	HIV-1 transgenic rat CD4 + T cells develop decreased CD28 responsiveness and suboptimal Lck tyrosine dephosphorylation following activation .
17038912	0	CD4	104,107	CD28	15,19	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Tregs|nmod|CD25 converted|dobj|Tregs converted|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD4	76,79	CD28	15,19	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY converted|dobj|Tregs converted|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17121217	0	CD4	40,43	CD28	21,25	CD4	CD28	920	940	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	-LSB- Abnormal changes of CD28 expression on CD4 + T cells in treatment-n ive and highly active antiretroviral therapy-treated HIV/AIDS patients -RSB- .
17144101	0	CD4	102,105	CD28	24,28	CD4	CD28	920	940	Gene	Gene	molecule|nmod|START_ENTITY molecule|compound|END_ENTITY	-LSB- Variable expression of CD28 costimulatory molecule and CTLA4 inhibitory molecule on peripheral blood CD4 + cells in kidney allograft recipients with and without acute graft rejection -RSB- .
17332357	0	CD4	118,121	CD28	0,4	CD4	CD28	920	940	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ repression|nmod|proliferation overcomes|dobj|repression overcomes|nsubj|costimulation costimulation|compound|END_ENTITY	CD28 costimulation overcomes transforming_growth_factor-beta-mediated repression of proliferation of redirected human CD4 + and CD8 + T cells in an antitumor cell attack .
17635872	0	CD4	93,96	CD28	13,17	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY requirements|nmod|immunity signaling|dobj|requirements costimulatory_molecule|xcomp|signaling costimulatory_molecule|nsubj|END_ENTITY	Differential CD28 and inducible costimulatory_molecule signaling requirements for protective CD4 + T-cell-mediated immunity against genital tract Chlamydia_trachomatis_infection .
17804530	0	CD4	55,58	CD28	60,64	CD4	CD28	920	940	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|dep|cells cells|compound|END_ENTITY	Surface expression of fractalkine_receptor -LRB- CX3CR1 -RRB- on CD4 + / CD28 T cells in RA patients and correlation with atherosclerotic_damage .
18346013	0	CD4	23,26	CD28	0,4	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY downregulation|nmod|cells downregulation|nummod|END_ENTITY	CD28 downregulation on CD4 + T cells is associated with age of kidney transplant recipient .
18446791	0	CD4	30,33	CD28	64,68	CD4	CD28	920	940	Gene	Gene	expansion|nmod|START_ENTITY T|nsubj|expansion T|ccomp|generates generates|nsubj|cells cells|nmod|END_ENTITY	Selective expansion of memory CD4 -LRB- + -RRB- T cells by mitogenic human CD28 generates inflammatory cytokines and regulatory T cells .
1847724	0	CD4	75,78	CD28	4,8	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY alloactivation|nmod|cells provides|nmod|alloactivation ligand|ccomp|provides ligand|nsubj|END_ENTITY	The CD28 ligand B7/BB1 provides costimulatory signal for alloactivation of CD4 + T cells .
18617642	0	CD4	24,27	CD28	0,4	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY down-regulation|nmod|cells down-regulation|nummod|END_ENTITY	CD28 down-regulation on CD4 T cells is a marker for graft dysfunction in lung transplant recipients .
18684917	0	CD4	63,66	CD28	0,4	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY controls|nmod|cells controls|nsubj|END_ENTITY	CD28 controls differentiation of regulatory T cells from naive CD4 T cells .
19394279	0	CD4	93,96	CD28	99,103	CD4	CD28	920	940	Gene	Gene	expression|nmod|START_ENTITY contribute|nmod|expression DNA|acl:relcl|contribute END_ENTITY|nsubj|DNA	Decreased DNA methyltransferase levels contribute to abnormal gene expression in `` senescent '' CD4 -LRB- + -RRB- CD28 -LRB- - -RRB- T cells .
19949106	0	CD4	0,3	CD28	56,60	CD4	CD28	920	940	Gene	Gene	CD25|compound|START_ENTITY regulatory|nsubj|CD25 regulatory|ccomp|resist resist|dobj|form form|nmod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells resist a novel form of CD28 - and Fas-dependent p53-induced T cell apoptosis .
19961728	0	CD4	50,53	CD28	80,84	CD4	CD28	920	940	Gene	Gene	changes|nmod|START_ENTITY Kv1|dobj|changes T|dep|Kv1 T|compound|END_ENTITY	-LSB- Kv1 .3 potassium channel expression changes after CD4 -LRB- + -RRB- and subsets CD28 -LRB- null -RRB- / CD28 -LRB- + -RRB- T cells activation in peripheral blood of patients with acute_coronary_syndrome -RSB- .
20126467	0	CD4	36,39	CD28	0,4	CD4	CD28	920	940	Gene	Gene	T-cells|compound|START_ENTITY circulating|dobj|T-cells down-regulation|acl|circulating down-regulation|nummod|END_ENTITY	CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic_pulmonary_fibrosis .
20880392	0	CD4	97,100	CD28	78,82	CD4	CD28	920	940	Gene	Gene	T-cells|compound|START_ENTITY explained|nmod|T-cells explained|nmod|differences differences|nmod|expression expression|compound|END_ENTITY	Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4 + effector memory T-cells .
21324454	0	CD4	0,3	CD28	4,8	CD4	CD28	920	940	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|nummod|END_ENTITY	CD4 + CD28 null T lymphocytes are expanded in young women with polycystic_ovary_syndrome .
21635686	0	CD4	113,116	CD28	117,121	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-15 preferentially enhances functional properties and antigen-specific responses of CD4 + CD28 -LRB- null -RRB- compared to CD4 + CD28 + T cells .
21949793	0	CD4	81,84	CD28	49,53	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY functions|nmod|cells functions|compound|END_ENTITY	Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4 + T cells .
22261542	0	CD4	4,7	CD28	49,53	CD4	CD28	920	940	Gene	Gene	subset|compound|START_ENTITY subset|acl|lacking lacking|dobj|expression expression|nmod|molecule molecule|compound|END_ENTITY	The CD4 + T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple_sclerosis .
22385243	0	CD4	14,17	CD28	81,85	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY respond|nsubj|cells respond|nmod|engagement engagement|compound|END_ENTITY	Human mucosal CD4 + T cells but not blood CD4 + T cells respond vigorously towards CD28 engagement .
22416257	0	CD4	109,112	CD28	76,80	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY stimulation|nmod|cells stimulation|compound|END_ENTITY	Granzyme_B - and Fas_ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4 + T cells .
22567259	0	CD4	62,65	CD28	54,58	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Decreased expression of T-cell costimulatory molecule CD28 on CD4 and CD8 T cells of mexican patients with pulmonary_tuberculosis .
22585421	0	CD4	7,10	CD28	25,29	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	help|compound|START_ENTITY necessary|nmod|help necessary|nsubj|costimulation costimulation|compound|END_ENTITY	Unlike CD4 + T-cell help , CD28 costimulation is necessary for effective primary CD8 + T-cell influenza-specific immunity .
22750548	0	CD4	95,98	CD28	112,116	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY chemokine|nmod|cells induces|dobj|chemokine induces|nmod|costimulation costimulation|compound|END_ENTITY	poly -LRB- I : C -RRB- costimulation induces a stronger antiviral chemokine and granzyme_B release in human CD4 T cells than CD28 costimulation .
22754764	0	CD4	112,115	CD28	60,64	CD4	CD28	920	940	Gene	Gene	T|compound|START_ENTITY induced|nmod|T END_ENTITY|acl|induced	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
22896637	0	CD4	14,17	CD28	0,4	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY promotes|dobj|expansion promotes|nsubj|END_ENTITY	CD28 promotes CD4 + T cell clonal expansion during infection independently of its YMNM and PYAP motifs .
23821416	1	CD4	56,59	CD28	62,66	CD4	CD28	920	940	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Part I : CD4 CD28 lymphocytes and common carotid artery intima-media_thickness .
23821417	1	CD4	66,69	CD28	72,76	CD4	CD28	920	940	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Part II : CD4 CD28 lymphocytes and carotid artery_atherosclerotic_plaque characteristics .
23859408	0	CD4	58,61	CD28	95,99	CD4	CD28	920	940	Gene	Gene	expansion|compound|START_ENTITY optimization|nmod|expansion method|nmod|optimization Influence|nmod|method using|dep|Influence END_ENTITY|dep|using	Influence of cell isolation method on the optimization of CD4 + T cell expansion using anti-CD3 / CD28 coated beads .
23948413	0	CD4	20,23	CD28	1,5	CD4	CD28	920	940	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- CD28 expression on CD4 -LRB- + -RRB- ; T cells and its relationship with IFN-y/IL -10 ratio in patients with primary immune_thrombocytopenia -RSB- .
24048955	0	CD4	26,29	CD28	0,4	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	T|compound|START_ENTITY signaling|nmod|T signaling|compound|END_ENTITY	CD28 signaling in primary CD4 -LRB- + -RRB- T cells : identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways .
24298980	0	CD4	96,99	CD28	88,92	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	T cells from chronic bone_infection show reduced proliferation and a high proportion of CD28 CD4 T cells .
24516382	0	CD4	140,143	CD28	22,26	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY expulsion|nmod|responses impairs|dobj|expulsion impairs|nsubj|deletion deletion|nmod|END_ENTITY	Inducible deletion of CD28 prior to secondary nippostrongylus brasiliensis_infection impairs worm expulsion and recall of protective memory CD4 T cell responses .
26155145	0	CD4	0,3	CD28	20,24	CD4	CD28	920	940	Gene	Gene	CD25|compound|START_ENTITY CD25|appos|END_ENTITY	CD4 + CD25 -LRB- high -RRB- , CD8 + CD28 - cells and thyroid autoantibodies in breast_cancer patients .
26613671	0	CD4	0,3	CD28	5,9	CD4	CD28	920	940	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	CD4 + CD28 Negative Cells : Armed and Dangerous .
7515929	0	CD4	32,35	CD28	88,92	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	+|compound|START_ENTITY Costimulation|nmod|+ Costimulation|appos|ligand ligand|nmod|END_ENTITY	Costimulation of tumor-reactive CD4 + and CD8 + T lymphocytes by B7 , a natural ligand for CD28 , can be used to treat established mouse melanoma .
7522154	0	CD4	74,77	CD28	109,113	CD4	CD28	920	940	Gene	Gene	T|compound|START_ENTITY stimulation|nmod|T responsiveness|nmod|stimulation cells|amod|responsiveness Differences|nmod|cells overcome|nsubjpass|Differences overcome|nmod|costimulation costimulation|compound|END_ENTITY	Differences in responsiveness to CD3 stimulation between naive and memory CD4 + T cells can not be overcome by CD28 costimulation .
7586736	0	CD4	49,52	CD28	95,99	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY Human_immunodeficiency_virus_type_1_infection|nmod|cells down-regulates|nsubj|Human_immunodeficiency_virus_type_1_infection down-regulates|dobj|expression expression|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1_infection of CD4 + T cells down-regulates the expression of CD28 : effect on T cell activation and cytokine production .
7697540	0	CD4	74,77	CD28	25,29	CD4	CD28	920	940	Gene	Gene	lymphocytes|compound|START_ENTITY +|dep|lymphocytes Alterations|parataxis|+ Alterations|nmod|levels levels|nmod|END_ENTITY	Alterations in levels of CD28 - / CD8 + suppressor cell precursor and CD45RO + / CD4 + memory T lymphocytes in the peripheral blood of multiple_sclerosis patients .
7822814	0	CD4	38,41	CD28	74,78	CD4	CD28	12504(Tax:10090)	12487(Tax:10090)	Gene	Gene	+|compound|START_ENTITY transduction|nmod|+ +|nsubj|transduction +|nmod|ligation ligation|compound|END_ENTITY	Distinct signal transduction in mouse CD4 + and CD8 + splenic_T cells after CD28 receptor ligation .
7875222	0	CD4	61,64	CD28	0,4	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY promotes|nmod|cells promotes|nsubj|activation activation|compound|END_ENTITY	CD28 activation promotes Th2 subset differentiation by human CD4 + cells .
7906302	0	CD4	42,45	CD28	18,22	CD4	CD28	920	940	Gene	Gene	+|compound|START_ENTITY antigen|nmod|+ antigen|compound|END_ENTITY	Downregulation of CD28 surface antigen on CD4 + and CD8 + T lymphocytes during HIV-1_infection .
8294878	0	CD4	22,25	CD28	135,139	CD4	CD28	920	940	Gene	Gene	thymocytes|compound|START_ENTITY selection|nmod|thymocytes requires|nsubj|selection requires|dobj|signal signal|acl:relcl|provided provided|nmod|END_ENTITY	Negative selection of CD4 + CD8 + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 .
8621791	0	CD4	0,3	CD28	10,14	CD4	CD28	920	940	Gene	Gene	CD7|compound|START_ENTITY CD7|dep|END_ENTITY	CD4 + CD7 - CD28 - T cells are expanded in rheumatoid_arthritis and are characterized by autoreactivity .
8943568	0	CD4	0,3	CD28	66,70	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY respond|nsubj|cells respond|xcomp|recall recall|nmod|ligation ligation|compound|END_ENTITY	CD4 + CD45RA + T cells from adults respond to recall antigens after CD28 ligation .
9382889	0	CD4	48,51	CD28	130,134	CD4	CD28	920	940	Gene	Gene	thymocytes|compound|START_ENTITY death|nmod|thymocytes death|nmod|mechanisms mechanisms|acl|differing differing|nmod|requirement requirement|nmod|costimulation costimulation|compound|END_ENTITY	T cell receptor -LRB- TCR -RRB- - induced death of immature CD4 + CD8 + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation : implications for negative selection in the thymus .
9550389	0	CD4	60,63	CD28	11,15	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells costimulation|nmod|proliferation costimulation|nsubj|Effects Effects|nmod|END_ENTITY	Effects of CD28 costimulation on long-term proliferation of CD4 + T cells in the absence of exogenous feeder cells .
9820490	0	CD4	30,33	CD28	80,84	CD4	CD28	920	940	Gene	Gene	suppression|nmod|START_ENTITY +|nsubj|suppression +|nmod|END_ENTITY	Specific suppression of human CD4 + Th cell responses to pig MHC antigens by CD8 + CD28 - regulatory T cells .
9834109	0	CD4	64,67	CD28	24,28	CD4	CD28	920	940	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells costimulation|nsubj|effects effects|nmod|END_ENTITY	Differential effects of CD28 costimulation on HIV production by CD4 + cells .
1370929	0	CD4	28,31	CD29	33,37	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Concomitant augmentation of CD4 + CD29 + helper inducer and diminution of CD4 + CD45RA + suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II .
1370929	0	CD4	72,75	CD29	33,37	CD4	CD29	920	3688	Gene	Gene	subset|compound|START_ENTITY inducer|nmod|subset helper|dobj|inducer helper|nsubj|augmentation augmentation|nmod|+ +|compound|END_ENTITY	Concomitant augmentation of CD4 + CD29 + helper inducer and diminution of CD4 + CD45RA + suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II .
1376382	0	CD4	58,61	CD29	62,66	CD4	CD29	920	3688	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Differential age-change in the numbers of CD4 + CD45RA + and CD4 + CD29 + T cell subsets in human peripheral blood .
1698987	0	CD4	37,40	CD29	43,47	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased number of peripheral blood CD4 + CD29 + lymphocytes and increased in vitro spontaneous production of anti-DNA antibodies in patients with active systemic_lupus_erythematosus .
1700468	0	CD4	124,127	CD29	128,132	CD4	CD29	12504(Tax:10090)	16412(Tax:10090)	Gene	Gene	CD45RA|compound|START_ENTITY CD45RA|compound|END_ENTITY	Purified human T cells stimulated with cross-linked anti-CD3 monoclonal antibody OKT3 : rIL-1 is a co-stimulatory factor for CD4 + CD29 + CD45RA - T cells .
1703056	0	CD4	28,31	CD29	32,36	CD4	CD29	920	3688	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Imbalance of CD4 + CD45R + and CD4 + CD29 + T helper cell subsets in patients with atopic_diseases .
1707762	0	CD4	42,45	CD29	46,50	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Differential responses of CD4 + CD45RA + and CD4 + CD29 + subsets to activated CD8 + cells : enhanced stimulation of the CD4 + CD45RA + subset by cells from patients with multiple_sclerosis .
17087927	0	CD4	0,3	CD29	101,105	CD4	CD29	920	3688	Gene	Gene	lymphocytes|compound|START_ENTITY require|nsubj|lymphocytes require|nmod|fibronectin fibronectin|dep|role role|nmod|beta beta|appos|END_ENTITY	CD4 + lymphocytes require platelets for adhesion to immobilized fibronectin in flow : role of beta -LRB- 1 -RRB- -LRB- CD29 -RRB- - , beta -LRB- 2 -RRB- -LRB- CD18 -RRB- - related integrins and non-integrin receptors .
1712366	0	CD4	39,42	CD29	43,47	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD21 + -LRB- B2 antigen + -RRB- cell decrement and CD4 + CD29 + -LRB- helper-inducer -RRB- cell increment suggest an activation of cell immune reactivity in multiple_sclerosis .
25386078	0	CD4	23,26	CD29	29,33	CD4	CD29	920	3688	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative_colitis patients .
2566120	0	CD4	71,74	CD29	54,58	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY molecule|nmod|+ molecule|compound|END_ENTITY	Suppressor effects and cyclic_AMP accumulation by the CD29 molecule of CD4 + lymphocytes .
2570801	0	CD4	77,80	CD29	81,85	CD4	CD29	920	3688	Gene	Gene	CD45R|compound|START_ENTITY CD45R|compound|END_ENTITY	Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4 + CD29 + CD45R - memory T lymphocytes .
7684891	0	CD4	13,16	CD29	17,21	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Imbalance of CD4 + CD29 + and CD4 + CD45RA + T-helper cell subsets in peripheral blood of patients with severe atopic_dermatitis .
7693106	0	CD4	0,3	CD29	15,19	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|appos|CD45RA CD45RA|nummod|END_ENTITY	CD4 + , CD45RA + , CD29 - T-cell_lymphocytic_leukemia functioning as T suppressor inducer for B-cell immunoglobulin synthesis .
9292944	0	CD4	99,102	CD29	104,108	CD4	CD29	920	3688	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased production of B-cell growth factor by T lymphocytes in Graves ' thyroid : possible role of CD4 + CD29 + cells .
9467397	0	CD4	19,22	CD29	0,4	CD4	CD29	920	3688	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|nummod|END_ENTITY	CD29 expression on CD4 + gingival lymphocytes supports migration of activated memory T lymphocytes to diseased periodontal tissue .
9473864	0	CD4	32,35	CD29	36,40	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increase in the helper inducer -LRB- CD4 + CD29 + -RRB- T lymphocytes in smokers .
9634196	0	CD4	29,32	CD29	115,119	CD4	CD29	920	3688	Gene	Gene	lines|compound|START_ENTITY induction|nmod|lines reactive|nsubj|induction reactive|xcomp|using using|nmod|END_ENTITY	Efficient induction of human CD4 + T cell lines reactive with a self-K-ras-derived peptide in vitro , using a mAb to CD29 .
9886155	0	CD4	20,23	CD29	24,28	CD4	CD29	920	3688	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increase in memory -LRB- CD4 + CD29 + and CD4 + CD45RO + -RRB- T and naive -LRB- CD4 + CD45RA + -RRB- T-cell subpopulations in smokers .
11119259	0	CD4	85,88	CD3	68,71	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY CD8|amod|END_ENTITY	Synchronous deletion of Mtv-superantigen-reactive thymocytes in the CD3 -LRB- medium/high -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- subset .
11222500	0	CD4	57,60	CD3	51,54	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY thymocytes|nsubj|CD8 thymocytes|nmod|END_ENTITY	Heterogeneity within medullary-type TCRalphabeta -LRB- + -RRB- CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- + -RRB- thymocytes in normal mouse thymus .
12150889	0	CD4	134,137	CD3	128,131	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Initiation of NALT organogenesis is independent of the IL-7R , LTbetaR , and NIK signaling pathways but requires the Id2 gene and CD3 -LRB- - -RRB- CD4 -LRB- + -RRB- CD45 -LRB- + -RRB- cells .
1347302	1	CD4	204,207	CD3	110,113	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	elimination|nmod|START_ENTITY inhibits|dobj|elimination inhibits|nsubj|Activation Activation|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Activation of T cells by the CD3 pathway inhibits anti-CD4-mediated T cell elimination and down-regulation of cell surface CD4 .
1350461	0	CD4	115,118	CD3	17,20	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	+|compound|START_ENTITY activation|nmod|+ frequency|nmod|activation enhances|dobj|frequency enhances|nsubj|Co-engagement Co-engagement|nmod|END_ENTITY	Co-engagement of CD3 with LFA-1 or ICAM-1 adhesion molecules enhances the frequency of activation of single murine CD4 + and CD8 + T cells and induces synthesis of IL-3 and IFN-gamma but not IL-4 or IL-6 .
15031541	4	CD4	535,538	CD3	529,532	CD4	CD3	395362(Tax:9031)	396518(Tax:9031)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	The percentage of CD3 -LRB- + -RRB- cells , CD4 -LRB- + -RRB- cells , CD8_alpha -LRB- + -RRB- cells , CD8_beta -LRB- + -RRB- , and CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells was 76 % , 41 % , 14 % , 5 % , and 15 % , respectively .
1673982	0	CD4	75,78	CD3	69,72	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|dep|- -|compound|END_ENTITY	Distinct subsets of accessory cells activate Thy-1 + triple negative -LRB- CD3 - , CD4 - , CD8 - -RRB- cells and Th-1 delayed-type_hypersensitivity effector T cells .
1691152	0	CD4	31,34	CD3	26,29	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immune surveillance : both CD3 + CD4 + and CD3 + CD8 + T cells control in vivo growth of P815 mastocytoma .
1696186	0	CD4	18,21	CD3	91,94	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY Subpopulations|nmod|cells Subpopulations|dep|END_ENTITY	Subpopulations of CD4 + cells in lpr/lpr mice : differences in expression of T_cell_receptor / CD3 complex and proliferative responses .
1696293	1	CD4	32,35	CD3	73,76	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	murine|dobj|START_ENTITY murine|parataxis|contain contain|dobj|+ +|appos|+ +|compound|END_ENTITY	Adult murine CD4 - , CD8 - thymocytes contain an NK1 .1 + , CD3 + , CD5hi , CD44hi , TCR-V beta 8 + subset .
1835792	0	CD4	19,22	CD3	29,32	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY Lymphocytes|nmod|CD8 Lymphocytes|dep|END_ENTITY	Lymphocytes with a CD4 + CD8 - CD3 - phenotype are effectors of experimental cutaneous_graft-versus-host_disease .
2088486	0	CD4	20,23	CD3	86,89	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	CD8-CD3|compound|START_ENTITY Ontogeny|nmod|CD8-CD3 Ontogeny|parataxis|subpopulation subpopulation|dep|END_ENTITY	Ontogeny of a novel CD4 + CD8-CD3 - thymocyte subpopulation : a comparison with CD4 - CD8 + CD3 - thymocytes .
2088486	0	CD4	76,79	CD3	86,89	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	comparison|nmod|START_ENTITY subpopulation|dep|comparison subpopulation|dep|END_ENTITY	Ontogeny of a novel CD4 + CD8-CD3 - thymocyte subpopulation : a comparison with CD4 - CD8 + CD3 - thymocytes .
24212096	0	CD4	72,75	CD3	35,38	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	T|compound|START_ENTITY Characteristics|nmod|T Characteristics|nmod|chains chains|compound|END_ENTITY	Characteristics of TCR/CD3 complex CD3 -LCB- varepsilon -RCB- chains of regulatory CD4 + T -LRB- Treg -RRB- lymphocytes : role in Treg differentiation in vitro and impact on Treg in vivo .
25168425	0	CD4	30,33	CD3	25,28	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	The role of intrahepatic CD3 + / CD4 - / CD8 - double_negative_T -LRB- DN_T -RRB- cells in enhanced acetaminophen toxicity .
2523934	0	CD4	50,53	CD3	45,48	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|+ +|compound|END_ENTITY	Phenotypic and functional analysis of murine CD3 + , CD4 - , CD8 - TCR-gamma delta-expressing peripheral T cells .
25445913	0	CD4	32,35	CD3	39,42	CD4	CD3	395362(Tax:9031)	396518(Tax:9031)	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of novel chicken CD4 -LRB- + -RRB- CD3 -LRB- - -RRB- blood population with NK cell like features .
26901413	0	CD4	105,108	CD3	98,101	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	IL-17 Induction by ArtinM is Due to Stimulation of IL-23_and_IL-1 Release and/or Interaction with CD3 in CD4 + T Cells .
2966738	0	CD4	88,91	CD3	2,5	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	+8|compound|START_ENTITY cells|nummod|+8 generation|nmod|cells intermediate|nmod|generation END_ENTITY|dep|intermediate	A CD3 - subset of CD4-8 + thymocytes : a rapidly cycling intermediate in the generation of CD4 +8 + cells .
3260917	0	CD4	24,27	CD3	18,21	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	-|compound|START_ENTITY +|appos|- +|compound|END_ENTITY	Peripheral murine CD3 + , CD4 - , CD8 - T lymphocytes express novel T cell receptor gamma delta structures .
8436820	0	CD4	42,45	CD3	47,50	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Characterization of an unusual cell type -LRB- CD4 + CD3 - -RRB- expanded by helminth infection and related to the parasite stress response .
8647197	0	CD4	109,112	CD3	94,97	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	+|compound|START_ENTITY complex|nmod|+ complex|advmod|END_ENTITY	CD4-dependent and - independent association of protein tyrosine kinases to the T_cell_receptor / CD3 complex of CD4 + mouse T lymphocytes .
9144481	0	CD4	142,145	CD3	88,91	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells activation|amod|antigen-mediated antigen-mediated|dep|antibody-induced antibody-induced|nmod:npmod|monoclonal monoclonal|nummod|END_ENTITY	Wortmannin , a phosphatidylinositol_3-kinase inhibitor , blocks antigen-mediated , but not CD3 monoclonal antibody-induced , activation of murine CD4 + T cells .
9300678	0	CD4	39,42	CD3	34,37	CD4	CD3	12504(Tax:10090)	12501(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|nummod|+ +|compound|END_ENTITY	Administration of IL-12 induces a CD3 + CD4 - CD8 - B220 + lymphoid population capable of eliciting cytolysis against Fas-positive tumor cells .
14726963	0	CD4	38,41	CD30	32,36	CD4	CD30	920	943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Pathophysiological functions of CD30 + CD4 + T cells in rheumatoid_arthritis .
15280854	0	CD4	32,35	CD30	55,59	CD4	CD30	920	943	Gene	Gene	START_ENTITY|dep|lymphoproliferative_disorder lymphoproliferative_disorder|compound|END_ENTITY	Progressive epidermotropic CD8 + / CD4 - primary cutaneous CD30 + lymphoproliferative_disorder in a patient with sarcoidosis .
16364153	0	CD4	0,3	CD30	5,9	CD4	CD30	920	943	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD4 + CD30 + T cells perpetuate IL-5 production in Dermatophagoides_pteronyssinus allergic patients .
17068147	0	CD4	60,63	CD30	6,10	CD4	CD30	12504(Tax:10090)	21941(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY transferred|dobj|cells adoptively|acl|transferred critical|nmod|adoptively critical|nsubj|signaling signaling|compound|END_ENTITY	Early CD30 signaling is critical for adoptively transferred CD4 + CD25 + regulatory T cells in prevention of acute_graft-versus-host_disease .
18078420	0	CD4	19,22	CD30	0,4	CD4	CD30	920	943	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	CD30 on stimulated CD4 + T lymphocytes in newborns regarding atopic_heredity .
18201430	0	CD4	51,54	CD30	24,28	CD4	CD30	920	943	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|molecules molecules|compound|END_ENTITY	Increased expression of CD30 and CD57 molecules on CD4 -LRB- + -RRB- T cells from children with atopic_asthma : a preliminary report .
18292503	0	CD4	45,48	CD30	20,24	CD4	CD30	12504(Tax:10090)	21941(Tax:10090)	Gene	Gene	homeostasis|compound|START_ENTITY signals|nmod|homeostasis signals|nsubj|synergy synergy|nmod|END_ENTITY	Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella .
1979248	0	CD4	30,33	CD30	8,12	CD4	CD30	920	943	Gene	Gene	+|compound|START_ENTITY +|dep|+ T|appos|+ Ki-1|dep|T Ki-1|appos|END_ENTITY	A Ki-1 -LRB- CD30 -RRB- - positive T -LRB- E + , CD4 + , Ia + -RRB- - cell line , DL-40 , established from aggressive_large_cell_lymphoma .
20625494	0	CD4	54,57	CD30	94,98	CD4	CD30	920	943	Gene	Gene	cells|compound|START_ENTITY ganglioside_GM1|nmod|cells expression|nmod|ganglioside_GM1 correlates|nsubj|expression correlates|dobj|form form|nmod|END_ENTITY	Increased expression of ganglioside_GM1 in peripheral CD4 + T cells correlates soluble form of CD30 in Systemic_Lupus_Erythematosus patients .
20631311	0	CD4	56,59	CD30	0,4	CD4	CD30	920	943	Gene	Gene	cells|compound|START_ENTITY heat_shock|dobj|cells heat_shock|nsubj|discriminates discriminates|compound|END_ENTITY	CD30 discriminates heat_shock protein 60-induced FOXP3 + CD4 + T cells with a regulatory phenotype .
25076300	0	CD4	65,68	CD30	56,60	CD4	CD30	920	943	Gene	Gene	lymphoma|appos|START_ENTITY lymphoma|compound|END_ENTITY	Transformation of small B-cell_lymphoma into large cell CD30 , CD4 , Epstein-Barr_virus-negative lymphoma .
25999672	0	CD4	66,69	CD30	70,74	CD4	CD30	920	943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracellular IL-4 , IL-5 , and IFN-y as the main characteristic of CD4 + CD30 + T cells after allergen stimulation in patients with vernal_keratoconjunctivitis .
26857493	0	CD4	34,37	CD30	15,19	CD4	CD30	12504(Tax:10090)	21941(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Requirement|nmod|cells Requirement|nmod|expression expression|compound|END_ENTITY	Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental_autoimmune_encephalomyelitis .
7821763	0	CD4	41,44	CD30	27,31	CD4	CD30	920	943	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Preferential expression of CD30 by human CD4 + T cells producing Th2-type cytokines .
12714245	0	CD4	47,50	CD31	29,33	CD4	CD31	920	5175	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Changes in the expression of CD31 and CXCR3 in CD4 + na ve T cells in elderly persons .
1345920	0	CD4	38,41	CD31	0,4	CD4	CD31	920	5175	Gene	Gene	cells|nummod|START_ENTITY marker|nmod|cells END_ENTITY|appos|marker	CD31 , a novel cell surface marker for CD4 cells of suppressor lineage , unaltered by state of activation .
18448620	0	CD4	119,122	CD31	94,98	CD4	CD31	920	5175	Gene	Gene	cells|compound|START_ENTITY Effects|nmod|cells Effects|nmod|expression expression|compound|END_ENTITY	Effects of delays in peripheral blood processing , including cryopreservation , on detection of CD31 expression on naive CD4 T cells .
18583570	0	CD4	51,54	CD31	23,27	CD4	CD31	920	5175	Gene	Gene	T-cell|compound|START_ENTITY Life|dep|T-cell Life|dep|+ +|compound|END_ENTITY	Life after the thymus : CD31 + and CD31 - human naive CD4 + T-cell subsets .
19008454	0	CD4	45,48	CD31	14,18	CD4	CD31	920	5175	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-7 sustains CD31 expression in human naive CD4 + T cells and preferentially expands the CD31 + subset in a PI3K-dependent manner .
19646767	0	CD4	77,80	CD31	98,102	CD4	CD31	920	5175	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 function|nmod|expansion function|nmod|T-cells T-cells|compound|END_ENTITY	Glatiramer_acetate improves regulatory T-cell function by expansion of naive CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- CD31 -LRB- + -RRB- T-cells in patients with multiple_sclerosis .
20065992	0	CD4	60,63	CD31	0,4	CD4	CD31	920	5175	Gene	Gene	T-cells|compound|START_ENTITY emigrants|nmod|T-cells marker|nmod|emigrants marker|nsubj|END_ENTITY	CD31 -LRB- PECAM-1 -RRB- is a marker of recent thymic emigrants among CD4 + T-cells , but not CD8 + T-cells or gammadelta T-cells , in HIV patients responding to ART .
21734076	0	CD4	20,23	CD31	0,4	CD4	CD31	12504(Tax:10090)	18613(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY required|nmod|cells required|nsubjpass|END_ENTITY	CD31 is required on CD4 + T cells to promote T cell survival during Salmonella_infection .
8394793	1	CD4	108,111	CD31	76,80	CD4	CD31	920	5175	Gene	Gene	subsets|nummod|START_ENTITY define|dobj|subsets help|xcomp|define markers|acl:relcl|help markers|appos|END_ENTITY	Human naive and memory T cells revisited : new markers -LRB- CD31 and CD27 -RRB- that help define CD4 + T cell subsets .
8707335	0	CD4	62,65	CD31	0,4	CD4	CD31	920	5175	Gene	Gene	maturation|compound|START_ENTITY lost|nmod|maturation antigen|acl|lost antigen|nsubj|END_ENTITY	CD31 -LRB- PECAM-1 -RRB- is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells .
11163640	0	CD4	39,42	CD38	185,189	CD4	CD38	920	952	Gene	Gene	T|compound|START_ENTITY susceptibility|nmod|T lymphocytes|nsubj|susceptibility lymphocytes|parataxis|associated associated|nmod|expression expression|nmod|molecules molecules|nummod|END_ENTITY	Differential susceptibility of resting CD4 -LRB- + -RRB- T lymphocytes to a T-tropic and a macrophage -LRB- M -RRB- - tropic human_immunodeficiency_virus_type_1 is associated with their surface expression of CD38 molecules .
15117448	0	CD4	60,63	CD38	4,8	CD4	CD38	920	952	Gene	Gene	loss|compound|START_ENTITY predict|dobj|loss predict|nsubj|cells cells|compound|END_ENTITY	CD8 + CD38 + T cells but not HIV_type_1 RNA viral load predict CD4 + T cell loss in a predominantly minority female HIV + adolescent population .
15764953	0	CD4	104,107	CD38	29,33	CD4	CD38	920	952	Gene	Gene	cells|nummod|START_ENTITY reconstitute|dobj|cells ability|acl|reconstitute influence|dobj|ability influence|nsubj|upregulation upregulation|nmod|END_ENTITY	Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4 + T cells under successful highly active antiretroviral therapy .
16920929	0	CD4	66,69	CD38	0,4	CD4	CD38	12504(Tax:10090)	12494(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY survival|nmod|cells required|nmod|survival required|nsubjpass|END_ENTITY	CD38 is required for the peripheral survival of immunotolerogenic CD4 + invariant NK T cells in nonobese diabetic mice .
18257774	0	CD4	59,62	CD38	0,4	CD4	CD38	920	952	Gene	Gene	recovery|compound|START_ENTITY association|nmod|recovery has|dobj|association has|nsubj|expression expression|nummod|END_ENTITY	CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy .
18784457	0	CD4	44,47	CD38	0,4	CD4	CD38	920	952	Gene	Gene	cells|nummod|START_ENTITY correlate|nmod|cells correlate|nsubj|T-cells T-cells|compound|END_ENTITY	CD38 + CD8 + T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals .
19072838	0	CD4	91,94	CD38	26,30	CD4	CD38	920	952	Gene	Gene	count|compound|START_ENTITY END_ENTITY|nmod|count	Close association of CD8 + / CD38 bright with HIV-1 replication and complex relationship with CD4 + T-cell count .
20108768	0	CD4	28,31	CD38	65,69	CD4	CD38	920	952	Gene	Gene	+|compound|START_ENTITY distribution|nmod|+ Frequency|appos|distribution CD8|nsubj|Frequency CD8|nmod|END_ENTITY	-LSB- Frequency , distribution of CD4 + , CD8 + T cells and expression of CD38 in gastric mucosa of HIV_infections -RSB- .
21469087	0	CD4	53,56	CD38	0,4	CD4	CD38	920	952	Gene	Gene	subset|compound|START_ENTITY identifies|dobj|subset identifies|nsubj|END_ENTITY	CD38 identifies a hypo-proliferative IL-13-secreting CD4 + T-cell subset that does not fit into existing naive and memory phenotype paradigms .
21937825	0	CD4	0,3	CD38	4,8	CD4	CD38	920	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD38 + HLA-DR + cells : a predictor of viral set point in Chinese men with primary_HIV_infection who have sex with men .
27100997	0	CD4	19,22	CD38	14,18	CD4	CD38	920	952	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	CD38 + CD8 + and CD38 + CD4 + T Cells and IFN_Gamma -LRB- +874 -RRB- Polymorphism Are Associated with a Poor Virological Outcome .
7554481	0	CD4	22,25	CD38	27,31	CD4	CD38	920	952	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	During HIV_infection , CD4 + CD38 + T-cells are the predominant circulating CD4 + subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4 + CD38 - T-cells .
7554481	0	CD4	73,76	CD38	27,31	CD4	CD38	920	952	Gene	Gene	subset|compound|START_ENTITY circulating|dobj|subset predominant|acl|circulating predominant|nsubj|T-cells T-cells|compound|END_ENTITY	During HIV_infection , CD4 + CD38 + T-cells are the predominant circulating CD4 + subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4 + CD38 - T-cells .
7686224	0	CD4	90,93	CD38	19,23	CD4	CD38	920	952	Gene	Gene	levels|compound|START_ENTITY value|nmod|levels add|nmod|value add|nsubj|levels levels|nmod|cells cells|compound|END_ENTITY	Elevated levels of CD38 + CD8 + T cells in HIV_infection add to the prognostic value of low CD4 + T cell levels : results of 6 years of follow-up .
7688270	0	CD4	112,115	CD38	4,8	CD4	CD38	920	952	Gene	Gene	counts|nummod|START_ENTITY correlate|nmod|counts +|ccomp|correlate +|nsubj|+ +|compound|END_ENTITY	CD8 + CD38 + and CD8 + DR + peripheral blood_lymphoid_subsets_of_HIV-infected intravenous drug abusers correlate with CD4 + cell counts and proliferation to mitogens .
7930717	0	CD4	159,162	CD38	105,109	CD4	CD38	920	952	Gene	Gene	levels|compound|START_ENTITY associated|nmod|levels lymphocyte|parataxis|associated lymphocyte|dobj|activation activation|dep|development development|nmod|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
8828739	0	CD4	86,89	CD38	42,46	CD4	CD38	920	952	Gene	Gene	cells|compound|START_ENTITY decline|nmod|cells predict|dobj|decline predict|nsubj|numbers numbers|nmod|cells cells|compound|END_ENTITY	Increased numbers of primed activated CD8 + CD38 + CD45RO + T cells predict the decline of CD4 + T cells in HIV-1-infected patients .
9358102	0	CD4	178,181	CD38	9,13	CD4	CD38	920	952	Gene	Gene	count|compound|START_ENTITY marker|nmod|count marker|nsubj|expression expression|compound|END_ENTITY	Elevated CD38 antigen expression on CD8 + T cells is a stronger marker for the risk of chronic HIV_disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4 + cell count , soluble immune activation markers , or combinations of HLA-DR and CD38 expression .
9621984	0	CD4	49,52	CD38	21,25	CD4	CD38	920	952	Gene	Gene	+|compound|START_ENTITY meaning|nmod|+ meaning|nmod|expression expression|compound|END_ENTITY	Different meaning of CD38 molecule expression on CD4 + and CD8 + cells of children perinatally infected with human_immunodeficiency_virus_type_1_infection surviving longer than five years .
9773872	0	CD4	110,113	CD38	16,20	CD4	CD38	920	952	Gene	Gene	T|compound|START_ENTITY expression|nmod|T using|dobj|expression expression|acl|using expression|compound|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9773872	0	CD4	92,95	CD38	16,20	CD4	CD38	920	952	Gene	Gene	expression|nummod|START_ENTITY using|dobj|expression expression|acl|using expression|compound|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9842886	0	CD4	18,21	CD38	0,4	CD4	CD38	920	952	Gene	Gene	cells|nummod|START_ENTITY CD45RB|dep|cells CD45RB|compound|END_ENTITY	CD38 + CD45RB -LRB- low -RRB- CD4 + T cells : a population of T cells with immune regulatory activities in vitro .
19427686	0	CD4	0,3	CD39	83,87	CD4	CD39	12504(Tax:10090)	12495(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|suppress suppress|nmod|END_ENTITY	CD4 + CD25 + regulatory T cells suppress contact_hypersensitivity reactions through a CD39 , adenosine-dependent mechanism .
19656134	0	CD4	28,31	CD39	9,13	CD4	CD39	12504(Tax:10090)	12495(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Isolated CD39 expression on CD4 + T cells denotes both regulatory and memory populations .
19957514	0	CD4	24,27	CD39	29,33	CD4	CD39	920	953	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Expression of FOXP3 in CD4 + CD39 + T cells of patients with systemic_lupus_erythematosus and dynamic observation of treatment with glucocorticoid -RSB- .
20977632	0	CD4	45,48	CD39	14,18	CD4	CD39	920	953	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression of CD39 by human peripheral blood CD4 + CD25 + T cells denotes a regulatory memory phenotype .
21513715	0	CD4	20,23	CD39	24,28	CD4	CD39	920	953	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Separation of human CD4 + CD39 + T cells by magnetic beads reveals two phenotypically and functionally different subsets .
21967895	0	CD4	27,30	CD39	22,26	CD4	CD39	920	953	Gene	Gene	function|compound|START_ENTITY Segregated|nsubj|function Segregated|dobj|END_ENTITY	Segregated regulatory CD39 + CD4 + T cell function : TGF-b-producing Foxp3 - and IL-10-producing Foxp3 + cells are interdependent for protection against collagen-induced_arthritis .
22349724	0	CD4	29,32	CD39	10,14	CD4	CD39	920	953	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Increased CD39 expression on CD4 -LRB- + -RRB- T lymphocytes has clinical and prognostic significance in chronic_lymphocytic_leukemia .
22585562	0	CD4	45,48	CD39	50,54	CD4	CD39	920	953	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
22585562	0	CD4	67,70	CD39	72,76	CD4	CD39	920	953	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
23409198	0	CD4	21,24	CD39	13,17	CD4	CD39	920	953	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion in CD39 CD4 immunoregulatory t cells and rarity of Th17 cells in HTLV-1 infected patients is associated with neurological_complications .
24749746	0	CD4	6,9	CD39	11,15	CD4	CD39	920	953	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD39 + regulatory T cells produce adenosine upon co-expression of surface CD73_or contact with CD73 + exosomes or CD73 + cells .
24752698	0	CD4	23,26	CD39	47,51	CD4	CD39	920	953	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human antigen-specific CD4 CD25 CD134 CD39 T cells are enriched for regulatory T cells and comprise a substantial proportion of recall responses .
26467610	0	CD4	84,87	CD39	135,139	CD4	CD39	920	953	Gene	Gene	CD25|compound|START_ENTITY subsets|nmod|CD25 subsets|dobj|cells cells|acl|identified identified|nmod|expression expression|nmod|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
9878110	0	CD4	45,48	CD3zeta	34,41	CD4	CD3zeta	12504(Tax:10090)	12503(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Increased Zap-70 association with CD3zeta in CD4 T cells from old mice .
10383941	0	CD4	64,67	CD4	77,80	CD4	CD4	920	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
10383941	0	CD4	77,80	CD4	64,67	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
11823493	0	CD4	107,110	CD4	76,79	CD4	CD4	920	920	Gene	Gene	CD8|compound|START_ENTITY required|nmod|CD8 required|nmod|development development|nmod|thymocytes thymocytes|amod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11823493	0	CD4	76,79	CD4	107,110	CD4	CD4	920	920	Gene	Gene	thymocytes|amod|START_ENTITY development|nmod|thymocytes required|nmod|development required|nmod|CD8 CD8|compound|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
12028564	0	CD4	0,3	CD4	71,74	CD4	CD4	920	920	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|ccomp|suppress suppress|dobj|proliferation proliferation|nmod|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12028564	0	CD4	71,74	CD4	0,3	CD4	CD4	920	920	Gene	Gene	CD25|compound|START_ENTITY proliferation|nmod|CD25 suppress|dobj|proliferation lymphocytes|ccomp|suppress lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + CD25 + T lymphocytes in human tonsils suppress the proliferation of CD4 + CD25 - tonsil cells .
12218108	0	CD4	11,14	CD4	68,71	CD4	CD4	920	12504(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Anti-human CD4 induces peripheral tolerance in a human CD4 + , murine CD4 - , HLA-DR + advanced transgenic mouse model .
12218108	0	CD4	68,71	CD4	11,14	CD4	CD4	12504(Tax:10090)	920	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	Anti-human CD4 induces peripheral tolerance in a human CD4 + , murine CD4 - , HLA-DR + advanced transgenic mouse model .
12804002	0	CD4	107,110	CD4	43,46	CD4	CD4	920	920	Gene	Gene	count|compound|START_ENTITY +|nmod|count +|nsubj|immunodeficiency_virus_infection immunodeficiency_virus_infection|nmod|CD8 CD8|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12804002	0	CD4	43,46	CD4	107,110	CD4	CD4	920	920	Gene	Gene	CD8|compound|START_ENTITY immunodeficiency_virus_infection|nmod|CD8 +|nsubj|immunodeficiency_virus_infection +|nmod|count count|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
1370929	0	CD4	28,31	CD4	72,75	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY augmentation|nmod|+ helper|nsubj|augmentation helper|dobj|inducer inducer|nmod|subset subset|compound|END_ENTITY	Concomitant augmentation of CD4 + CD29 + helper inducer and diminution of CD4 + CD45RA + suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II .
1370929	0	CD4	72,75	CD4	28,31	CD4	CD4	920	920	Gene	Gene	subset|compound|START_ENTITY inducer|nmod|subset helper|dobj|inducer helper|nsubj|augmentation augmentation|nmod|+ +|compound|END_ENTITY	Concomitant augmentation of CD4 + CD29 + helper inducer and diminution of CD4 + CD45RA + suppressor inducer subset in patients infected with human T cell lymphotropic virus types I or II .
14991599	0	CD4	139,142	CD4	54,57	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY counter-regulated|nmod|cells cells|acl:relcl|counter-regulated Demonstration|dep|cells Demonstration|nmod|reactivity reactivity|nmod|CD25 CD25|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991599	0	CD4	54,57	CD4	139,142	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY reactivity|nmod|CD25 Demonstration|nmod|reactivity Demonstration|dep|cells cells|acl:relcl|counter-regulated counter-regulated|nmod|cells cells|compound|END_ENTITY	Demonstration of strong enterobacterial reactivity of CD4 + CD25 - T cells from conventional and germ-free mice which is counter-regulated by CD4 + CD25 + T cells .
14991600	0	CD4	31,34	CD4	80,83	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	MHC class II-independent CD25 + CD4 + CD8alpha beta + alpha beta T cells attenuate CD4 + T cell-induced transfer colitis .
14991600	0	CD4	80,83	CD4	31,34	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	MHC class II-independent CD25 + CD4 + CD8alpha beta + alpha beta T cells attenuate CD4 + T cell-induced transfer colitis .
15322152	0	CD4	0,3	CD4	41,44	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY cells|acl|controlling controlling|dobj|response response|compound|END_ENTITY	CD4 + CD25 + cells controlling a pathogenic CD4 response inhibit cytokine differentiation , CXCR-3 expression , and tissue invasion .
15322152	0	CD4	41,44	CD4	0,3	CD4	CD4	920	920	Gene	Gene	response|compound|START_ENTITY controlling|dobj|response cells|acl|controlling cells|compound|END_ENTITY	CD4 + CD25 + cells controlling a pathogenic CD4 response inhibit cytokine differentiation , CXCR-3 expression , and tissue invasion .
15630140	0	CD4	14,17	CD4	36,39	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Conversion|nmod|CD25 Conversion|dep|cells cells|nmod|+ +|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15630140	0	CD4	36,39	CD4	14,17	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ Conversion|dep|cells Conversion|nmod|CD25 CD25|compound|END_ENTITY	Conversion of CD4 + CD25 - cells into CD4 + CD25 + regulatory T cells in vivo requires B7 costimulation , but not the thymus .
15649266	0	CD4	62,65	CD4	74,77	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY recruitment|nmod|+ induces|dobj|recruitment induces|parataxis|+ +|nsubj|interferon-gamma interferon-gamma|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15649266	0	CD4	74,77	CD4	62,65	CD4	CD4	920	920	Gene	Gene	interferon-gamma|compound|START_ENTITY +|nsubj|interferon-gamma induces|parataxis|+ induces|dobj|recruitment recruitment|nmod|+ +|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15657288	0	CD4	100,103	CD4	78,81	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY play|nmod|cells play|dobj|role role|nmod|suppression suppression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4 + T lymphocytes by CD4 + CD25 + regulatory T cells .
15657288	0	CD4	78,81	CD4	100,103	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY suppression|nmod|lymphocytes role|nmod|suppression play|dobj|role play|nmod|cells cells|compound|END_ENTITY	NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4 + T lymphocytes by CD4 + CD25 + regulatory T cells .
15679891	0	CD4	15,18	CD4	25,28	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY changes|nmod|+ changes|dep|proportion proportion|nummod|END_ENTITY	The changes of CD4 + CD25 + / CD4 + proportion in spleen of tumor-bearing BALB/c mice .
15679891	0	CD4	25,28	CD4	15,18	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	proportion|nummod|START_ENTITY changes|dep|proportion changes|nmod|+ +|compound|END_ENTITY	The changes of CD4 + CD25 + / CD4 + proportion in spleen of tumor-bearing BALB/c mice .
15710910	0	CD4	47,50	CD4	86,89	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nmod|cells cells|compound|END_ENTITY	A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25 + CD4 T cells in vivo .
15710910	0	CD4	86,89	CD4	47,50	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY response|nmod|cells response|compound|END_ENTITY	A model of suppression of the antigen-specific CD4 T cell response by regulatory CD25 + CD4 T cells in vivo .
15728475	0	CD4	43,46	CD4	73,76	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY +|nmod|CD25 CD25|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD4	73,76	CD4	43,46	CD4	CD4	920	920	Gene	Gene	CD25|compound|START_ENTITY +|nmod|CD25 +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15753318	0	CD4	39,42	CD4	79,82	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ cells|dep|generation cells|nmod|CD25 CD25|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15753318	0	CD4	79,82	CD4	39,42	CD4	CD4	920	920	Gene	Gene	CD25|compound|START_ENTITY cells|nmod|CD25 cells|dep|generation generation|nmod|+ +|compound|END_ENTITY	De novo generation of antigen-specific CD4 + CD25 + regulatory T cells from human CD4 + CD25 - cells .
15840697	0	CD4	0,3	CD4	72,75	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY control|nsubj|cells control|dobj|induction induction|nmod|responses responses|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients .
15840697	0	CD4	72,75	CD4	0,3	CD4	CD4	920	920	Gene	Gene	responses|compound|START_ENTITY induction|nmod|responses control|dobj|induction control|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control the induction of antigen-specific CD4 + helper T cell responses in cancer patients .
16339542	0	CD4	118,121	CD4	6,9	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells express|ccomp|enhances express|nsubj|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16339542	0	CD4	6,9	CD4	118,121	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|ccomp|enhances enhances|nmod|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16775487	0	CD4	0,3	CD4	41,44	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|nmod|pool pool|compound|END_ENTITY	CD4 + CD25 + cell depletion from the normal CD4 + T cell pool prevents tolerance toward the intestinal flora and leads to chronic_colitis in immunodeficient mice .
16775487	0	CD4	41,44	CD4	0,3	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	pool|compound|START_ENTITY depletion|nmod|pool depletion|compound|END_ENTITY	CD4 + CD25 + cell depletion from the normal CD4 + T cell pool prevents tolerance toward the intestinal flora and leads to chronic_colitis in immunodeficient mice .
1690353	0	CD4	57,60	CD4	91,94	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ regulation|nmod|expression thymocytes|nsubj|regulation thymocytes|dep|influenced influenced|nmod|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
1690353	0	CD4	91,94	CD4	57,60	CD4	CD4	920	920	Gene	Gene	influenced|nmod|START_ENTITY thymocytes|dep|influenced thymocytes|nsubj|regulation regulation|nmod|expression expression|nmod|+ +|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
17038912	0	CD4	104,107	CD4	76,79	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Tregs|nmod|CD25 Tregs|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17038912	0	CD4	76,79	CD4	104,107	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nmod|CD25 CD25|compound|END_ENTITY	Requirement of CD28 signaling in homeostasis/survival of TGF-beta converted CD4 + CD25 + Tregs from thymic CD4 + CD25 - single positive T cells .
17082610	0	CD4	38,41	CD4	61,64	CD4	CD4	920	920	Gene	Gene	targets|compound|START_ENTITY imposed|nmod|targets imposed|nmod|cells cells|compound|END_ENTITY	Distinct molecular program imposed on CD4 + T cell targets by CD4 + CD25 + regulatory T cells .
17082610	0	CD4	61,64	CD4	38,41	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY imposed|nmod|cells imposed|nmod|targets targets|compound|END_ENTITY	Distinct molecular program imposed on CD4 + T cell targets by CD4 + CD25 + regulatory T cells .
17090688	0	CD4	102,105	CD4	61,64	CD4	CD4	920	920	Gene	Gene	line|compound|START_ENTITY differentiation|nmod|line differentiation|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
17090688	0	CD4	61,64	CD4	102,105	CD4	CD4	920	920	Gene	Gene	differentiation|compound|START_ENTITY differentiation|nmod|line line|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
17113120	0	CD4	107,110	CD4	51,54	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY needed|nsubjpass|ligation disease|dep|needed mediate|dobj|disease cells|acl:relcl|mediate cells|compound|END_ENTITY	Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease : Is CD4 T_cell_receptor ligation needed ?
17113120	0	CD4	51,54	CD4	107,110	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|mediate mediate|dobj|disease disease|dep|needed needed|nsubjpass|ligation ligation|compound|END_ENTITY	Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease : Is CD4 T_cell_receptor ligation needed ?
17123986	0	CD4	0,3	CD4	20,23	CD4	CD4	920	920	Gene	Gene	T-cell|compound|START_ENTITY counts|nsubj|T-cell counts|dep|count count|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + T-cell counts , CD4 + / CD8 + T-cell count ratios , and antibody levels in migrant fishermen infected with Schistosoma_japonicum in the Dongting Lake , China .
17123986	0	CD4	20,23	CD4	0,3	CD4	CD4	920	920	Gene	Gene	T-cell|compound|START_ENTITY count|nsubj|T-cell counts|dep|count counts|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + T-cell counts , CD4 + / CD8 + T-cell count ratios , and antibody levels in migrant fishermen infected with Schistosoma_japonicum in the Dongting Lake , China .
17244157	0	CD4	0,3	CD4	55,58	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY corrected|nsubj|-LSB- corrected|ccomp|render render|dobj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17244157	0	CD4	55,58	CD4	0,3	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY render|dobj|CD25 corrected|ccomp|render corrected|nsubj|-LSB- -LSB-|compound|END_ENTITY	CD4 + CD25 + -LSB- corrected -RSB- regulatory T cells render naive CD4 + CD25 - T cells anergic and suppressive .
17270282	0	CD4	101,104	CD4	17,20	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells suppression|nmod|costimulation suppression|compound|END_ENTITY	CpG DNA inhibits CD4 + CD25 + Treg suppression through direct MyD88-dependent costimulation of effector CD4 + T cells .
17270282	0	CD4	17,20	CD4	101,104	CD4	CD4	920	920	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|costimulation costimulation|nmod|cells cells|compound|END_ENTITY	CpG DNA inhibits CD4 + CD25 + Treg suppression through direct MyD88-dependent costimulation of effector CD4 + T cells .
17545218	0	CD4	149,152	CD4	87,90	CD4	CD4	920	920	Gene	Gene	cells|nummod|START_ENTITY promotes|nmod|cells promotes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17545218	0	CD4	87,90	CD4	149,152	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells promotes|dobj|differentiation promotes|nmod|cells cells|nummod|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17675505	0	CD4	105,108	CD4	18,21	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY reveal|dobj|cells reveal|nmod|cells cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17675505	0	CD4	18,21	CD4	105,108	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reveal|nmod|cells reveal|dobj|cells cells|nummod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17785792	0	CD4	53,56	CD4	73,76	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY transcription|nmod|cells suppression|nmod|transcription suppression|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17785792	0	CD4	73,76	CD4	53,56	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells suppression|nmod|transcription transcription|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17875988	0	CD4	21,24	CD4	61,64	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|acl|+ +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD4	61,64	CD4	21,24	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells CD25|acl|+ CD25|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17967941	0	CD4	129,132	CD4	67,70	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY +|advcl|cells +|nsubj|impact impact|nmod|inhibition inhibition|nmod|Foxp3 Foxp3|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17967941	0	CD4	67,70	CD4	129,132	CD4	CD4	920	920	Gene	Gene	Foxp3|compound|START_ENTITY inhibition|nmod|Foxp3 impact|nmod|inhibition +|nsubj|impact +|advcl|cells cells|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17982458	0	CD4	0,3	CD4	94,97	CD4	CD4	920	920	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|induce induce|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
17982458	0	CD4	94,97	CD4	0,3	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells induce|dobj|apoptosis +|ccomp|induce +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
18270250	0	CD4	25,28	CD4	43,46	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY cells|nmod|FOXP3 FOXP3|compound|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18270250	0	CD4	43,46	CD4	25,28	CD4	CD4	920	920	Gene	Gene	FOXP3|compound|START_ENTITY cells|nmod|FOXP3 cells|compound|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18272926	0	CD4	27,30	CD4	50,53	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD4	50,53	CD4	27,30	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells CD25|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18602973	0	CD4	152,155	CD4	166,169	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY commitment|nmod|+ controlling|dobj|commitment controlling|nmod|thymocytes thymocytes|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
18602973	0	CD4	166,169	CD4	152,155	CD4	CD4	920	920	Gene	Gene	thymocytes|compound|START_ENTITY controlling|nmod|thymocytes controlling|dobj|commitment commitment|nmod|+ +|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
19089812	0	CD4	36,39	CD4	89,92	CD4	CD4	920	920	Gene	Gene	Treg|compound|START_ENTITY Treg|nmod|patients patients|nmod|END_ENTITY	High frequency and proliferation of CD4 + FOXP3 + Treg in HIV-1-infected patients with low CD4 counts .
19089812	0	CD4	89,92	CD4	36,39	CD4	CD4	920	920	Gene	Gene	patients|nmod|START_ENTITY Treg|nmod|patients Treg|compound|END_ENTITY	High frequency and proliferation of CD4 + FOXP3 + Treg in HIV-1-infected patients with low CD4 counts .
19208751	0	CD4	17,20	CD4	24,27	CD4	CD4	920	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	HIV-1 binding to CD4 on CD4 + CD25 + regulatory T cells enhances their suppressive function and induces them to home to , and accumulate in , peripheral and mucosal lymphoid tissues : an additional mechanism of immunosuppression .
19208751	0	CD4	24,27	CD4	17,20	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	HIV-1 binding to CD4 on CD4 + CD25 + regulatory T cells enhances their suppressive function and induces them to home to , and accumulate in , peripheral and mucosal lymphoid tissues : an additional mechanism of immunosuppression .
19462377	0	CD4	22,25	CD4	48,51	CD4	CD4	920	920	Gene	Gene	Treg|compound|START_ENTITY required|nmod|Treg required|xcomp|control control|dobj|proliferation proliferation|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19462377	0	CD4	48,51	CD4	22,25	CD4	CD4	920	920	Gene	Gene	proliferation|compound|START_ENTITY control|dobj|proliferation required|xcomp|control required|nmod|Treg Treg|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
1970729	0	CD4	22,25	CD4	40,43	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD4	40,43	CD4	22,25	CD4	CD4	920	920	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
20121403	0	CD4	12,15	CD4	79,82	CD4	CD4	404704(Tax:9823)	404704(Tax:9823)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|cells cells|compound|END_ENTITY	Circulating CD4 + CD25high regulatory T cells and expression of PD-1 and BTLA on CD4 + T cells in patients with chronic hepatitis_B_virus infection .
20121403	0	CD4	79,82	CD4	12,15	CD4	CD4	404704(Tax:9823)	404704(Tax:9823)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells +|nsubj|END_ENTITY	Circulating CD4 + CD25high regulatory T cells and expression of PD-1 and BTLA on CD4 + T cells in patients with chronic hepatitis_B_virus infection .
20525892	0	CD4	106,109	CD4	56,59	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|resistance resistance|nmod|FoxP3 FoxP3|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	CD4	56,59	CD4	106,109	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY resistance|nmod|FoxP3 induces|dobj|resistance induces|nmod|cells cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20570629	0	CD4	128,131	CD4	77,80	CD4	CD4	920	920	Gene	Gene	CD25|compound|START_ENTITY restrain|dobj|CD25 mechanisms|acl:relcl|restrain mechanisms|nmod|cell cell|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
20570629	0	CD4	77,80	CD4	128,131	CD4	CD4	920	920	Gene	Gene	cell|compound|START_ENTITY mechanisms|nmod|cell mechanisms|acl:relcl|restrain restrain|dobj|CD25 CD25|compound|END_ENTITY	IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4 + CD25 + regulatory T cell which jointly restrain CD4 + CD25 - cell activation .
21472340	0	CD4	63,66	CD4	87,90	CD4	CD4	920	920	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	CD4	87,90	CD4	63,66	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Foxp3|dep|cells Foxp3|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21557210	0	CD4	0,3	CD4	46,49	CD4	CD4	920	920	Gene	Gene	cells|amod|START_ENTITY cells|dep|population population|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21557210	0	CD4	46,49	CD4	0,3	CD4	CD4	920	920	Gene	Gene	population|compound|START_ENTITY cells|dep|population cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21702013	0	CD4	109,112	CD4	39,42	CD4	CD4	920	920	Gene	Gene	Treg|compound|START_ENTITY juvenile_idiopathic_arthritis|nmod|Treg cells|amod|juvenile_idiopathic_arthritis patients|nmod|cells cells|nmod|patients suppression|dep|cells suppression|nmod|CD25 CD25|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
21702013	0	CD4	39,42	CD4	109,112	CD4	CD4	920	920	Gene	Gene	CD25|compound|START_ENTITY suppression|nmod|CD25 suppression|dep|cells cells|nmod|patients patients|nmod|cells cells|amod|juvenile_idiopathic_arthritis juvenile_idiopathic_arthritis|nmod|Treg Treg|compound|END_ENTITY	Impaired suppression of synovial_fluid CD4 + CD25 - T cells from patients with juvenile_idiopathic_arthritis by CD4 + CD25 + Treg cells .
22028728	0	CD4	130,133	CD4	69,72	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|nummod|END_ENTITY	Polymerized-type I collagen induces upregulation of Foxp3-expressing CD4 regulatory T cells and downregulation of IL-17-producing CD4 T cells -LRB- Th17 -RRB- cells in collagen-induced_arthritis .
22028728	0	CD4	69,72	CD4	130,133	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|cells cells|compound|END_ENTITY	Polymerized-type I collagen induces upregulation of Foxp3-expressing CD4 regulatory T cells and downregulation of IL-17-producing CD4 T cells -LRB- Th17 -RRB- cells in collagen-induced_arthritis .
2243395	0	CD4	106,109	CD4	148,151	CD4	CD4	920	920	Gene	Gene	interaction|nmod|START_ENTITY blocks|nsubj|interaction blocks|dobj|movement movement|nmod|END_ENTITY	Intracellular interaction of human_immunodeficiency_virus_type_1 -LRB- ARV-2 -RRB- envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane .
2243395	0	CD4	148,151	CD4	106,109	CD4	CD4	920	920	Gene	Gene	movement|nmod|START_ENTITY blocks|dobj|movement blocks|nsubj|interaction interaction|nmod|END_ENTITY	Intracellular interaction of human_immunodeficiency_virus_type_1 -LRB- ARV-2 -RRB- envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane .
22870329	0	CD4	60,63	CD4	78,81	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY conversion|nmod|cells inhibits|dobj|conversion inhibits|nmod|cells cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22870329	0	CD4	78,81	CD4	60,63	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|conversion conversion|nmod|cells cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22891289	0	CD4	124,127	CD4	97,100	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY CD25-FoxP3|nummod|+ Tregs|nmod|CD25-FoxP3 Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891289	0	CD4	97,100	CD4	124,127	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nmod|CD25-FoxP3 CD25-FoxP3|nummod|+ +|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891805	0	CD4	107,110	CD4	99,102	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dep|cells	Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4 -LRB- + -RRB- / CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- cells .
22891805	0	CD4	99,102	CD4	107,110	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|nummod|END_ENTITY	Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4 -LRB- + -RRB- / CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- cells .
23028916	0	CD4	110,113	CD4	27,30	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY function|nmod|T inhibiting|dobj|function vitro|advcl|inhibiting cells|amod|vitro expansion|nmod|cells expansion|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23028916	0	CD4	27,30	CD4	110,113	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY expansion|nmod|cells cells|amod|vitro vitro|advcl|inhibiting inhibiting|dobj|function function|nmod|T T|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23971188	0	CD4	75,78	CD4	90,93	CD4	CD4	407098(Tax:9913)	407098(Tax:9913)	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ proliferation|dep|cells cells|compound|END_ENTITY	Dexamethasone , but not meloxicam , suppresses proliferation of bovine CD25 + CD4 + and CD25 - CD4 + T cells .
23971188	0	CD4	90,93	CD4	75,78	CD4	CD4	407098(Tax:9913)	407098(Tax:9913)	Gene	Gene	cells|compound|START_ENTITY proliferation|dep|cells proliferation|nmod|+ +|compound|END_ENTITY	Dexamethasone , but not meloxicam , suppresses proliferation of bovine CD25 + CD4 + and CD25 - CD4 + T cells .
25199644	0	CD4	52,55	CD4	70,73	CD4	CD4	920	920	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs CXCR5|dep|Bregs CXCR5|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	CD4	70,73	CD4	52,55	CD4	CD4	920	920	Gene	Gene	CXCR5|compound|START_ENTITY CXCR5|dep|Bregs Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
2523311	1	CD4	113,116	CD4	189,192	CD4	CD4	920	920	Gene	Gene	-|compound|START_ENTITY Induction|appos|- Induction|appos|+ +|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD4	189,192	CD4	113,116	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY Induction|appos|+ Induction|appos|- -|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
25293774	0	CD4	0,3	CD4	100,103	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY invariant|nsubj|+ GVHD|dep|invariant GVHD|nmod|expansion expansion|nmod|+ +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25293774	0	CD4	100,103	CD4	0,3	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ GVHD|nmod|expansion GVHD|dep|invariant invariant|nsubj|+ +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
26553468	0	CD4	15,18	CD4	62,65	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|nummod|START_ENTITY responses|nmod|Foxp3 Foxp3|compound|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26553468	0	CD4	62,65	CD4	15,18	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY responses|nmod|Foxp3 responses|nummod|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26590312	0	CD4	13,16	CD4	83,86	CD4	CD4	920	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|Cells Cells|compound|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
26590312	0	CD4	83,86	CD4	13,16	CD4	CD4	920	920	Gene	Gene	Cells|compound|START_ENTITY +|nmod|Cells +|nsubj|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
26962115	0	CD4	115,118	CD4	91,94	CD4	CD4	920	920	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|Cells Conversion|dep|Cells Conversion|nmod|FOXP3 FOXP3|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
26962115	0	CD4	91,94	CD4	115,118	CD4	CD4	920	920	Gene	Gene	FOXP3|compound|START_ENTITY Conversion|nmod|FOXP3 Conversion|dep|Cells Cells|nmod|Cells Cells|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
7554481	0	CD4	22,25	CD4	73,76	CD4	CD4	920	920	Gene	Gene	T-cells|compound|START_ENTITY predominant|nsubj|T-cells predominant|acl|circulating circulating|dobj|subset subset|compound|END_ENTITY	During HIV_infection , CD4 + CD38 + T-cells are the predominant circulating CD4 + subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4 + CD38 - T-cells .
7554481	0	CD4	73,76	CD4	22,25	CD4	CD4	920	920	Gene	Gene	subset|compound|START_ENTITY circulating|dobj|subset predominant|acl|circulating predominant|nsubj|T-cells T-cells|compound|END_ENTITY	During HIV_infection , CD4 + CD38 + T-cells are the predominant circulating CD4 + subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4 + CD38 - T-cells .
7901153	0	CD4	0,3	CD4	92,95	CD4	CD4	920	920	Gene	Gene	comodulated|nsubjpass|START_ENTITY comodulated|nmod|activation activation|nmod|line line|compound|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7901153	0	CD4	92,95	CD4	0,3	CD4	CD4	920	920	Gene	Gene	line|compound|START_ENTITY activation|nmod|line comodulated|nmod|activation comodulated|nsubjpass|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7902376	0	CD4	45,48	CD4	8,11	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|cells cells|compound|END_ENTITY	Role of CD4 + T cells in the expansion of the CD4 - , CD8 - gamma delta T cell subset in the spleens of mice during blood-stage malaria .
7902376	0	CD4	8,11	CD4	45,48	CD4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Role|nmod|cells Role|nmod|END_ENTITY	Role of CD4 + T cells in the expansion of the CD4 - , CD8 - gamma delta T cell subset in the spleens of mice during blood-stage malaria .
8289789	0	CD4	33,36	CD4	52,55	CD4	CD4	920	920	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	33,36	CD4	75,78	CD4	CD4	920	920	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene +|nsubj|expression +|dobj|cells cells|dep|T T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	52,55	CD4	33,36	CD4	CD4	920	920	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	52,55	CD4	75,78	CD4	CD4	920	920	Gene	Gene	gene|nmod|START_ENTITY expression|nmod|gene +|nsubj|expression +|dobj|cells cells|dep|T T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	75,78	CD4	33,36	CD4	CD4	920	920	Gene	Gene	T|compound|START_ENTITY cells|dep|T +|dobj|cells +|nsubj|expression expression|nmod|gene gene|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	75,78	CD4	52,55	CD4	CD4	920	920	Gene	Gene	T|compound|START_ENTITY cells|dep|T +|dobj|cells +|nsubj|expression expression|nmod|gene gene|nmod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8415641	0	CD4	17,20	CD4	47,50	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY Precommitment|nmod|+ thymocytes|nsubj|Precommitment thymocytes|nmod|lineages lineages|compound|END_ENTITY	Precommitment of CD4 + CD8 + thymocytes to either CD4 or CD8 lineages .
8415641	0	CD4	47,50	CD4	17,20	CD4	CD4	920	920	Gene	Gene	lineages|compound|START_ENTITY thymocytes|nmod|lineages thymocytes|nsubj|Precommitment Precommitment|nmod|+ +|compound|END_ENTITY	Precommitment of CD4 + CD8 + thymocytes to either CD4 or CD8 lineages .
8556507	0	CD4	155,158	CD4	32,35	CD4	CD4	920	920	Gene	Gene	lymphocytes|compound|START_ENTITY level|nmod|lymphocytes prompted|nmod|level prompted|nsubj|Characterization Characterization|acl|circulating circulating|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD4	32,35	CD4	155,158	CD4	CD4	920	920	Gene	Gene	lymphocytes|nummod|START_ENTITY circulating|dobj|lymphocytes Characterization|acl|circulating prompted|nsubj|Characterization prompted|nmod|level level|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8737717	0	CD4	0,3	CD4	42,45	CD4	CD4	920	920	Gene	Gene	cytopenia|compound|START_ENTITY cytopenia|nmod|+ +|compound|END_ENTITY	CD4 cytopenia and occasional expansion of CD4 + CD8 + lymphocytes in Sj gren 's _ syndrome .
8737717	0	CD4	42,45	CD4	0,3	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY cytopenia|nmod|+ cytopenia|compound|END_ENTITY	CD4 cytopenia and occasional expansion of CD4 + CD8 + lymphocytes in Sj gren 's _ syndrome .
9022017	0	CD4	19,22	CD4	86,89	CD4	CD4	395362(Tax:9031)	395362(Tax:9031)	Gene	Gene	population|compound|START_ENTITY population|dep|inheritance inheritance|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9022017	0	CD4	86,89	CD4	19,22	CD4	CD4	395362(Tax:9031)	395362(Tax:9031)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells inheritance|nmod|expression population|dep|inheritance population|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9182876	0	CD4	30,33	CD4	46,49	CD4	CD4	920	920	Gene	Gene	gene|compound|START_ENTITY gene|nmod|T T|compound|END_ENTITY	Specific demethylation of the CD4 gene during CD4 T lymphocyte differentiation .
9182876	0	CD4	46,49	CD4	30,33	CD4	CD4	920	920	Gene	Gene	T|compound|START_ENTITY gene|nmod|T gene|compound|END_ENTITY	Specific demethylation of the CD4 gene during CD4 T lymphocyte differentiation .
9209493	0	CD4	25,28	CD4	93,96	CD4	CD4	920	920	Gene	Gene	+|compound|START_ENTITY +|dep|T T|compound|END_ENTITY	Differential response of CD4 + V7 + and CD4 + V7 - T cells to T cell receptor-dependent signals : CD4 + V7 + T cells are co-stimulation independent and anti-V7 antibody blocks the induction of anergy by bacterial superantigen .
9209493	0	CD4	93,96	CD4	25,28	CD4	CD4	920	920	Gene	Gene	T|compound|START_ENTITY +|dep|T +|compound|END_ENTITY	Differential response of CD4 + V7 + and CD4 + V7 - T cells to T cell receptor-dependent signals : CD4 + V7 + T cells are co-stimulation independent and anti-V7 antibody blocks the induction of anergy by bacterial superantigen .
9773872	0	CD4	110,113	CD4	92,95	CD4	CD4	920	920	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9773872	0	CD4	92,95	CD4	110,113	CD4	CD4	920	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
10395323	0	CD4	29,32	CD40	97,101	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	Conversion|nmod|START_ENTITY +|nsubj|Conversion +|nmod|ligation ligation|nmod|END_ENTITY	Conversion of tumor-specific CD4 + T-cell tolerance to T-cell priming through in vivo ligation of CD40 .
10444266	0	CD4	35,38	CD40	10,14	CD4	CD40	920	958	Gene	Gene	cells|compound|START_ENTITY ligand|nmod|cells ligand|nsubj|END_ENTITY	Decreased CD40 ligand induction in CD4 T cells and dysregulated IL-12 production during HIV_infection .
10516078	0	CD4	29,32	CD40	16,20	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	T|compound|START_ENTITY ligand|dobj|T ligand|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement for CD40 ligand , CD4 -LRB- + -RRB- T cells , and B cells in an infectious_mononucleosis-like_syndrome .
10528180	0	CD4	29,32	CD40	0,4	CD4	CD40	920	958	Gene	Gene	tolerance|compound|START_ENTITY induces|dobj|tolerance induces|nsubj|blockade blockade|nummod|END_ENTITY	CD40 ligand blockade induces CD4 + T cell tolerance and linked suppression .
10590269	0	CD4	0,3	CD40	122,126	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|requires requires|dobj|expression expression|nummod|END_ENTITY	CD4 -LRB- + -RRB- T cell-mediated protection against a lethal outcome of systemic_infection with vesicular_stomatitis virus requires CD40 ligand expression , but not IFN-gamma or IL-4 .
10684857	0	CD4	42,45	CD40	0,4	CD4	CD40	920	958	Gene	Gene	T|compound|START_ENTITY response|compound|T triggers|dobj|response ligand|ccomp|triggers ligand|nsubj|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- triggers a short-term CD4 -LRB- + -RRB- T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis .
10700427	0	CD4	47,50	CD40	24,28	CD4	CD40	920	958	Gene	Gene	cells|compound|START_ENTITY CD154|nmod|cells ligand|dobj|CD154 ligand|nsubj|expression expression|nmod|END_ENTITY	Increased expression of CD40 ligand -LRB- CD154 -RRB- on CD4 + T cells as a marker of disease activity in rheumatoid_arthritis .
10936029	0	CD4	49,52	CD40	24,28	CD4	CD40	920	958	Gene	Gene	lymphocytes|compound|START_ENTITY ligand|nmod|lymphocytes ligand|nsubj|expression expression|nmod|END_ENTITY	Increased expression of CD40 ligand in activated CD4 + T lymphocytes of systemic_sclerosis patients .
10940889	0	CD4	144,147	CD40	110,114	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells induce|dep|expression induce|nmod|induction induction|nmod|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
11017148	0	CD4	146,149	CD40	48,52	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY independent|nmod|cells initiate|dobj|independent initiate|nsubj|genetically genetically|acl|modified modified|xcomp|express express|dobj|END_ENTITY	Dendritic_cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4 + T cells .
11034421	0	CD4	0,3	CD40	37,41	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|nmod|END_ENTITY	CD4 + T lymphocytes with constitutive CD40 ligand in preautoimmune -LRB- NZB x NZW -RRB- F1 lupus-prone mice : phenotype and possible role in autoreactivity .
11120867	0	CD4	24,27	CD40	0,4	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	lymphocytes|nummod|START_ENTITY prevents|nsubj|lymphocytes replaces|ccomp|prevents replaces|nsubj|signaling signaling|compound|END_ENTITY	CD40 signaling replaces CD4 + lymphocytes and its blocking prevents chronic rejection of heart transplants .
11353832	0	CD4	40,43	CD40	16,20	CD4	CD40	920	958	Gene	Gene	function|compound|START_ENTITY substitute|nmod|function substitute|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus .
11602857	0	CD4	66,69	CD40	16,20	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY pathways|nmod|cells pathways|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of the CD40 and CD28 pathways on alloimmune responses by CD4 + T cells in vivo .
11698440	0	CD4	55,58	CD40	0,4	CD4	CD40	920	958	Gene	Gene	priming|nmod|START_ENTITY promotes|xcomp|priming promotes|nsubj|ligand ligand|compound|END_ENTITY	CD40 ligand promotes priming of fully potent antitumor CD4 -LRB- + -RRB- T cells in draining lymph nodes in the presence of apoptotic tumor cells .
11751400	0	CD4	57,60	CD40	0,4	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY requirement|nmod|cells bypasses|dobj|requirement bypasses|nsubj|cross-linking cross-linking|compound|END_ENTITY	CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunization with melanoma antigen gene-modified dendritic cells .
12270549	0	CD4	42,45	CD40	0,4	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	tolerance|compound|START_ENTITY inhibit|dobj|tolerance inhibit|nsubj|stimulation stimulation|nummod|END_ENTITY	CD40 stimulation in vivo does not inhibit CD4 + T cell tolerance to soluble antigens .
12507785	0	CD4	58,61	CD40	0,4	CD4	CD40	920	958	Gene	Gene	adhesion|compound|START_ENTITY regulates|dobj|adhesion regulates|nsubj|END_ENTITY	CD40 expressed by human brain endothelial cells regulates CD4 + T cell adhesion to endothelium .
15294958	0	CD4	91,94	CD40	0,4	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	+|compound|START_ENTITY priming|nmod|+ enhances|dobj|priming enhances|nsubj|engagement engagement|compound|END_ENTITY	CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4 + and CD8 + T cells independently of IL-12 .
15634890	0	CD4	143,146	CD40	45,49	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY absence|nmod|cells contributes|nmod|absence contributes|nsubj|Induction Induction|nmod|CD70 CD70|nmod|cells cells|nmod|stimulation stimulation|compound|END_ENTITY	Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8 + T cell responses in the absence of CD4 + T cells .
15958635	0	CD4	48,51	CD40	71,75	CD4	CD40	920	958	Gene	Gene	induction|nmod|START_ENTITY vitro|dobj|induction vitro|nsubj|gene gene|nummod|END_ENTITY	In vitro induction of myeloid_leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins .
16365447	0	CD4	0,3	CD40	30,34	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|xcomp|expressing expressing|ccomp|ligand ligand|nsubj|END_ENTITY	CD4 + T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell type .
18354158	0	CD4	117,120	CD40	0,4	CD4	CD40	920	958	Gene	Gene	help|compound|START_ENTITY absence|nmod|help needed|nmod|absence needed|nsubjpass|END_ENTITY	CD40 on APCs is needed for optimal programming , maintenance , and recall of CD8 + T cell memory even in the absence of CD4 + T cell help .
18469093	0	CD4	62,65	CD40	66,70	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
19670423	0	CD4	0,3	CD40	44,48	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY promote|nsubj|cells promote|dobj|inflammation inflammation|nmod|signaling signaling|compound|END_ENTITY	CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver_ischemia / reperfusion_injury .
19778641	0	CD4	21,24	CD40	78,82	CD4	CD40	920	958	Gene	Gene	T-cell|nsubj|START_ENTITY T-cell|advcl|inducing inducing|dobj|expression expression|nmod|ligand ligand|nummod|END_ENTITY	Doxorubicin enhances CD4 -LRB- + -RRB- T-cell immune responses by inducing expression of CD40 ligand and 4-1BB .
22002241	0	CD4	56,59	CD40	35,39	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	+|compound|START_ENTITY drives|dep|+ drives|compound|END_ENTITY	Intratumoral interleukin-2 / agonist CD40 antibody drives CD4 + - independent resolution of treated-tumors and CD4 + - dependent systemic and memory responses .
22105491	0	CD4	19,22	CD40	0,4	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells engagement|nummod|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
22105491	0	CD4	19,22	CD40	24,28	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
22851303	0	CD4	128,131	CD40	70,74	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells ligand|xcomp|expression ligand|nmod|END_ENTITY	Differential modulation by delta9-tetrahydrocannabinol -LRB- 9 -RRB- - THC -RRB- of CD40 ligand -LRB- CD40L -RRB- expression in activated mouse splenic CD4 + T cells .
23615121	0	CD4	96,99	CD40	45,49	CD4	CD40	920	958	Gene	Gene	+|compound|START_ENTITY repertoire|nmod|+ expands|dobj|repertoire expands|csubj|Targeting Targeting|nmod|END_ENTITY	Targeting concatenated HIV antigens to human CD40 expands a broad repertoire of multifunctional CD4 + and CD8 + T cells .
7509825	0	CD4	47,50	CD40	0,4	CD4	CD40	920	958	Gene	Gene	lymphocytes|compound|START_ENTITY activation|nmod|lymphocytes costimulates|dobj|activation costimulates|nsubj|END_ENTITY	CD40 preferentially costimulates activation of CD4 + T lymphocytes .
7699321	0	CD4	12,15	CD40	51,55	CD4	CD40	920	958	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells contains|nsubj|subset contains|dobj|ligand ligand|compound|END_ENTITY	A subset of CD4 + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex .
8103067	0	CD4	80,83	CD40	46,50	CD4	CD40	920	958	Gene	Gene	cells|nummod|START_ENTITY regulation|nmod|cells regulation|appos|END_ENTITY	The regulation of the expression of gp39 , the CD40 ligand , on normal and cloned CD4 + T cells .
8605928	0	CD4	81,84	CD40	44,48	CD4	CD40	920	958	Gene	Gene	cells|compound|START_ENTITY ligand|nmod|cells END_ENTITY|acl|ligand	Endothelial cells augment the expression of CD40 ligand on newly activated human CD4 + T cells through a CD2/LFA -3 signaling pathway .
8892618	0	CD4	38,41	CD40	94,98	CD4	CD40	920	958	Gene	Gene	cells|compound|START_ENTITY provide|nsubj|cells provide|dobj|help help|nmod|ligand ligand|compound|END_ENTITY	Herpesvirus_saimiri-transformed human CD4 + T cells can provide polyclonal B cell help via the CD40 ligand as well as the TNF-alpha pathway and through release of lymphokines .
8977172	0	CD4	49,52	CD40	12,16	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	T|compound|START_ENTITY impairs|dobj|T impairs|nsubj|Blockade Blockade|nmod|interaction interaction|compound|END_ENTITY	Blockade of CD40 ligand-CD40 interaction impairs CD4 + T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation .
8977315	0	CD4	96,99	CD40	53,57	CD4	CD40	920	958	Gene	Gene	cells|compound|START_ENTITY interaction|nmod|cells TRAP|nmod|interaction TRAP|parataxis|ligand ligand|nsubj|END_ENTITY	Induction , regulation , and function of soluble TRAP -LRB- CD40 ligand -RRB- during interaction of primary CD4 + CD45RA + T cells with dendritic cells .
9012830	0	CD4	94,97	CD40	111,115	CD4	CD40	920	958	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Increased interleukin 12 production in progressive multiple_sclerosis : induction by activated CD4 + T cells via CD40 ligand .
9151338	0	CD4	0,3	CD40	89,93	CD4	CD40	920	958	Gene	Gene	cells|nummod|START_ENTITY have|nsubj|cells have|dobj|ability ability|nmod|END_ENTITY	CD4 + cells from patients with Common_Variable_Immunodeficiency have a reduced ability of CD40 ligand membrane expression after in vitro stimulation .
9257841	0	CD4	66,69	CD40	98,102	CD4	CD40	12504(Tax:10090)	21939(Tax:10090)	Gene	Gene	T|compound|START_ENTITY vitro|nmod|T lymphocytes|amod|vitro markers|nmod|lymphocytes Induction|nmod|markers Induction|dep|role role|nmod|ligand ligand|nummod|END_ENTITY	Induction of germinal center B cell markers in vitro by activated CD4 + T lymphocytes : the role of CD40 ligand , soluble factors , and B cell antigen receptor cross-linking .
9682002	0	CD4	61,64	CD40	24,28	CD4	CD40	920	958	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|nummod|END_ENTITY	Glucocorticoids inhibit CD40 ligand expression of peripheral CD4 + lymphocytes .
11260318	0	CD4	84,87	CD40L	132,137	CD4	CD40L	920	959	Gene	Gene	killer|compound|START_ENTITY culture|nmod|killer apoptosis|nmod|culture cells|amod|apoptosis undergo|dobj|cells undergo|xcomp|expressing expressing|dobj|END_ENTITY	Dendritic_cells rapidly undergo apoptosis in vitro following culture with activated CD4 + Valpha24 natural killer T cells expressing CD40L .
11399230	0	CD4	119,122	CD40L	44,49	CD4	CD40L	920	959	Gene	Gene	immunity|compound|START_ENTITY enhance|dobj|immunity plasmid|ccomp|enhance CD40L|acl|plasmid Modulation|dep|CD40L Modulation|nmod|responses responses|nmod|END_ENTITY	Modulation of cellular responses by plasmid CD40L : CD40L plasmid vectors enhance antigen-specific helper T cell type 1 CD4 + T cell-mediated protective immunity against herpes_simplex_virus type 2 in vivo .
11399230	0	CD4	119,122	CD40L	51,56	CD4	CD40L	920	959	Gene	Gene	immunity|compound|START_ENTITY enhance|dobj|immunity plasmid|ccomp|enhance END_ENTITY|acl|plasmid	Modulation of cellular responses by plasmid CD40L : CD40L plasmid vectors enhance antigen-specific helper T cell type 1 CD4 + T cell-mediated protective immunity against herpes_simplex_virus type 2 in vivo .
11981828	0	CD4	78,81	CD40L	84,89	CD4	CD40L	920	959	Gene	Gene	+|compound|START_ENTITY +|appos|cells cells|nummod|+ +|compound|END_ENTITY	Chronic_lymphocytic_leukemia B cells are endowed with the capacity to attract CD4 + , CD40L + T cells by producing CCL22 .
12234621	0	CD4	80,83	CD40L	36,41	CD4	CD40L	920	959	Gene	Gene	T|nsubj|START_ENTITY modulates|parataxis|T modulates|dobj|expression expression|nummod|END_ENTITY	Cyclic_AMP differentially modulates CD40L expression on human nai ; ve and memory CD4 -LRB- + -RRB- T cells .
12390318	0	CD4	72,75	CD40L	63,68	CD4	CD40L	920	959	Gene	Gene	cells|nummod|START_ENTITY increases|nmod|cells increases|dobj|expression expression|nmod|END_ENTITY	Ribavirin increases mitogen - and antigen-induced expression of CD40L on CD4 + T cells in vivo .
14976397	0	CD4	46,49	CD40L	8,13	CD4	CD40L	920	959	Gene	Gene	T-lymphocytes|compound|START_ENTITY activated|dobj|T-lymphocytes activated|nsubj|expression expression|compound|END_ENTITY	Reduced CD40L expression on ex vivo activated CD4 + T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure .
15993419	0	CD4	37,40	CD40L	52,57	CD4	CD40L	920	959	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Isolation of viable antigen-specific CD4 T cells by CD40L surface trapping .
16617733	0	CD4	23,26	CD40L	1,6	CD4	CD40L	920	959	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	-LSB- CD40L expression on T CD4 + lymphocytes from peripheral blood in patients with relapsing-remitting and secondary progressive multiple_sclerosis -RSB- .
16815973	0	CD4	6,9	CD40L	41,46	CD4	CD40L	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival .
18838544	0	CD4	7,10	CD40L	0,5	CD4	CD40L	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	CD40L + CD4 + memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming .
21151195	0	CD4	34,37	CD40L	0,5	CD4	CD40L	920	959	Gene	Gene	memory|compound|START_ENTITY +|nmod|memory co-stimulation|nmod|+ cells|amod|co-stimulation cells|nummod|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21151195	0	CD4	72,75	CD40L	0,5	CD4	CD40L	920	959	Gene	Gene	expansion|nummod|START_ENTITY supports|dobj|expansion supports|nsubj|cells cells|nummod|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21460206	0	CD4	104,107	CD40L	97,102	CD4	CD40L	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L + CD4 + memory T cells .
22851303	0	CD4	128,131	CD40L	83,88	CD4	CD40L	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|dep|END_ENTITY	Differential modulation by delta9-tetrahydrocannabinol -LRB- 9 -RRB- - THC -RRB- of CD40 ligand -LRB- CD40L -RRB- expression in activated mouse splenic CD4 + T cells .
24117612	0	CD4	40,43	CD40L	31,36	CD4	CD40L	920	959	Gene	Gene	cells|compound|START_ENTITY Upregulation|nmod|cells Upregulation|nmod|END_ENTITY	Upregulation of membrane-bound CD40L on CD4 + T cells in women with primary Sj gren 's syndrome .
9691083	0	CD4	0,3	CD40L	74,79	CD4	CD40L	920	959	Gene	Gene	T|compound|START_ENTITY T|acl:relcl|tolerized tolerized|nmod|antibody antibody|amod|ligand ligand|dep|END_ENTITY	CD4 -LRB- + -RRB- T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand -LRB- CD40L : CD154 -RRB- antibody lose their graft-versus-host_disease lethality capacity but retain nominal antigen responses .
9826442	0	CD4	67,70	CD40L	22,27	CD4	CD40L	920	959	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|plays plays|nsubj|TNF-alpha TNF-alpha|appos|CD154 CD154|appos|END_ENTITY	TNF-alpha , not CD154 -LRB- CD40L -RRB- , plays a major role in SEB-dependent , CD4 -LRB- + -RRB- T cell-induced endothelial cell activation in vitro .
10949194	0	CD4	53,56	CD40_ligand	11,22	CD4	CD40 ligand	920	959	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Heightened CD40_ligand gene expression in peripheral CD4 + T cells from patients with kidney allograft rejection .
11401990	0	CD4	128,131	CD40_ligand	113,124	CD4	CD40 ligand	920	959	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Distinct cytokine regulation by cholera toxin and type II heat-labile toxins involves differential regulation of CD40_ligand on CD4 -LRB- + -RRB- T cells .
12563087	0	CD4	29,32	CD40_ligand	14,25	CD4	CD40 ligand	920	959	Gene	Gene	T-cells|compound|START_ENTITY END_ENTITY|nmod|T-cells	Expression of CD40_ligand on CD4 + T-cells and platelets correlated to the coronary_artery_lesion and disease progress in Kawasaki_disease .
14517846	0	CD4	40,43	CD40_ligand	0,11	CD4	CD40 ligand	920	959	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	CD40_ligand is selectively expressed on CD4 + T cells and platelets : implications for CD40-CD40L signalling in atherosclerosis .
17595332	0	CD4	75,78	CD40_ligand	10,21	CD4	CD40 ligand	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ exists|dobj|cells exists|nsubj|END_ENTITY	Preformed CD40_ligand exists in secretory lysosomes in effector and memory CD4 + T cells and is quickly expressed on the cell surface in an antigen-specific manner .
23999542	0	CD4	127,130	CD40_ligand	65,76	CD4	CD40 ligand	920	959	Gene	Gene	T|compound|START_ENTITY tetrahydrocannabinol|nmod|T cells|amod|tetrahydrocannabinol involved|dobj|cells involved|nmod|suppression suppression|nmod|expression expression|amod|END_ENTITY	Impaired NFAT and NFkB activation are involved in suppression of CD40_ligand expression by / \ -LRB- 9 -RRB- - tetrahydrocannabinol in human CD4 -LRB- + -RRB- T cells .
8617933	0	CD4	42,45	CD40_ligand	21,32	CD4	CD40 ligand	920	959	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	Cross-linking of the CD40_ligand on human CD4 + T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis .
8671613	0	CD4	46,49	CD40_ligand	14,25	CD4	CD40 ligand	12504(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Regulation of CD40_ligand expression on naive CD4 T cells : a role for TCR but not co-stimulatory signals .
10069424	0	CD4	95,98	CD43	31,35	CD4	CD43	920	6693	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells expressed|nmod|subset expressed|nsubjpass|O-glycans O-glycans|nmod|END_ENTITY	Core 2-containing O-glycans on CD43 are preferentially expressed in the memory subset of human CD4 T cells .
11110701	0	CD4	63,66	CD43	45,49	CD4	CD43	12504(Tax:10090)	20737(Tax:10090)	Gene	Gene	clones|nummod|START_ENTITY expressed|nmod|clones expressed|nsubj|function function|nmod|glycoform glycoform|nmod|END_ENTITY	Antiadhesive function of 130-kd glycoform of CD43 expressed in CD4 T-lymphocyte clones and transfectant cell lines .
15187099	0	CD4	70,73	CD43	131,135	CD4	CD43	920	6693	Gene	Gene	cells|compound|START_ENTITY CD43|nmod|cells characteristics|nmod|CD43 characteristics|dep|analysis analysis|acl|using using|nmod|END_ENTITY	Expression characteristics and stimulatory functions of CD43 in human CD4 + memory T cells : analysis using a monoclonal antibody to CD43 that has a novel lineage specificity .
15187099	0	CD4	70,73	CD43	56,60	CD4	CD43	920	6693	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression characteristics and stimulatory functions of CD43 in human CD4 + memory T cells : analysis using a monoclonal antibody to CD43 that has a novel lineage specificity .
15668924	0	CD4	66,69	CD43	43,47	CD4	CD43	12504(Tax:10090)	20737(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY changes|nmod|cells changes|nmod|END_ENTITY	Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells .
16500623	0	CD4	30,33	CD43	24,28	CD4	CD43	12504(Tax:10090)	20737(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Upregulation of ICOS on CD43 + CD4 + murine small intestinal intraepithelial lymphocytes during acute reovirus_infection .
17638845	0	CD4	33,36	CD43	18,22	CD4	CD43	12504(Tax:10090)	20737(Tax:10090)	Gene	Gene	trafficking|nummod|START_ENTITY Signaling|nsubj|trafficking Signaling|nmod|END_ENTITY	Signaling through CD43 regulates CD4 T-cell trafficking .
18036228	0	CD4	57,60	CD43	0,4	CD4	CD43	920	6693	Gene	Gene	cells|compound|START_ENTITY commitment|nmod|cells induce|dobj|commitment signals|xcomp|induce signals|nsubj|END_ENTITY	CD43 signals induce Type One lineage commitment of human CD4 + T cells .
20070216	0	CD4	7,10	CD43	43,47	CD4	CD43	920	6693	Gene	Gene	subsets|compound|START_ENTITY discriminated|nsubj|subsets discriminated|nmod|level level|compound|END_ENTITY	Memory CD4 T-cell subsets discriminated by CD43 expression level in A-bomb survivors .
7537557	0	CD4	46,49	CD43	27,31	CD4	CD43	12504(Tax:10090)	20737(Tax:10090)	Gene	Gene	+|compound|START_ENTITY glycoforms|nmod|+ glycoforms|nummod|END_ENTITY	Differential regulation of CD43 glycoforms on CD4 + and CD8 + T lymphocytes in graft-versus-host_disease .
8554898	0	CD4	69,72	CD43	113,117	CD4	CD43	920	6693	Gene	Gene	human_immunodeficiency_virus_infection|nmod|START_ENTITY Enhanced|xcomp|human_immunodeficiency_virus_infection T|amod|Enhanced lymphocytes|nsubj|T lymphocytes|xcomp|deficient deficient|nmod|END_ENTITY	Enhanced susceptibility to human_immunodeficiency_virus_infection in CD4 + T lymphocytes genetically deficient in CD43 .
8778031	0	CD4	113,116	CD43	34,38	CD4	CD43	920	6693	Gene	Gene	+|compound|START_ENTITY subsets|nmod|+ subsets|nsubj|pattern pattern|nmod|expression expression|nmod|END_ENTITY	Parallel pattern of expression of CD43 and of LFA-1 on the CD45RA + -LRB- naive -RRB- and CD45RO + -LRB- memory -RRB- subsets of human CD4 + and CD8 + cells .
16497973	0	CD4	15,18	CD44	7,11	CD4	CD44	920	960	Gene	Gene	Th1|compound|START_ENTITY END_ENTITY|nmod|Th1	Use of CD44 by CD4 + Th1 and Th2 lymphocytes to roll and adhere .
9176107	0	CD4	61,64	CD44	76,80	CD4	CD44	12504(Tax:10090)	12505(Tax:10090)	Gene	Gene	CD3|compound|START_ENTITY proliferation|nmod|CD3 inhibit|dobj|proliferation inhibit|parataxis|thymocytes thymocytes|nsubj|+ +|compound|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
10050677	0	CD4	75,78	CD45	0,4	CD4	CD45	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	+|compound|START_ENTITY early|nmod|+ thymocytes|amod|early act|nmod|thymocytes act|nsubj|END_ENTITY	CD45 can act as a negative regulator for the transition from early to late CD4 + CD8 + thymocytes .
10602008	0	CD4	42,45	CD45	0,4	CD4	CD45	920	5788	Gene	Gene	phenotypes|dep|START_ENTITY phenotypes|nummod|END_ENTITY	CD45 isoform phenotypes of human T cells : CD4 -LRB- + -RRB- CD45RA -LRB- - -RRB- RO -LRB- + -RRB- memory T cells re-acquire CD45RA without losing CD45RO .
10809380	0	CD4	52,55	CD45	25,29	CD4	CD45	920	5788	Gene	Gene	+|compound|START_ENTITY expressed|nmod|+ expressed|nsubj|distribution distribution|nmod|isoforms isoforms|nummod|END_ENTITY	Abnormal distribution of CD45 isoforms expressed by CD4 + and CD8 + T cells in rheumatoid_arthritis .
11166373	0	CD4	83,86	CD45	50,54	CD4	CD45	920	5788	Gene	Gene	T|compound|START_ENTITY antigen|nmod|T antigen|nummod|END_ENTITY	Deficiency of the expression of CD45RA isoform of CD45 common leukocyte antigen in CD4 + T lymphocytes in children with infantile cholestasis .
11694532	0	CD4	47,50	CD45	28,32	CD4	CD45	920	5788	Gene	Gene	isoforms|nmod|START_ENTITY isoforms|nummod|END_ENTITY	Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T_cell_antigen_receptor signal transduction .
12204964	0	CD4	11,14	CD45	53,57	CD4	CD45	920	5788	Gene	Gene	START_ENTITY|dep|T-cell T-cell|dep|gating gating|nummod|END_ENTITY	Affordable CD4 -LRB- + -RRB- - T-cell counting by flow cytometry : CD45 gating for volumetric analysis .
12583540	0	CD4	51,54	CD45	83,87	CD4	CD45	920	5788	Gene	Gene	T-cell|compound|START_ENTITY performing|dobj|T-cell Guidelines|acl|performing determinations|nsubj|Guidelines determinations|nmod|END_ENTITY	Guidelines for performing single-platform absolute CD4 + T-cell determinations with CD45 gating for persons infected with human immunodeficiency virus .
1351092	0	CD4	53,56	CD45	0,4	CD4	CD45	920	19264(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nummod|END_ENTITY	CD45 alternative exon expression in murine and human CD4 + T cell subsets .
1384687	0	CD4	149,152	CD45	33,37	CD4	CD45	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY heterogeneity|nmod|cells marker|nmod|heterogeneity epitope|nmod|marker expression|dep|epitope expression|nmod|structures structures|nummod|END_ENTITY	Differential expression of three CD45 alternative structures on murine T cells : exon 6-dependent epitope as a marker for functional heterogeneity of CD4 + T cells .
14577504	0	CD4	38,41	CD45	19,23	CD4	CD45	920	5788	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Down regulation of CD45 expression on CD4 T cells during acute renal allograft rejection : evidence of a decline in T suppressor/inducer activity .
1532148	0	CD4	15,18	CD45	109,113	CD4	CD45	920	5788	Gene	Gene	Interaction|nmod|START_ENTITY induces|nsubj|Interaction induces|nmod|absence absence|nmod|phosphatase phosphatase|compound|END_ENTITY	Interaction of CD4 : lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase .
1682382	0	CD4	52,55	CD45	15,19	CD4	CD45	920	5788	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|levels levels|nmod|END_ENTITY	High levels of CD45 are coordinately expressed with CD4 and CD8 on avian thymocytes .
1716520	0	CD4	52,55	CD45	0,4	CD4	CD45	920	5788	Gene	Gene	cells|nummod|START_ENTITY functions|nmod|cells associated|nmod|functions associated|nsubj|isoforms isoforms|compound|END_ENTITY	CD45 isoforms associated with distinct functions of CD4 cells derived from unusual healthy donors lacking CD45RA - T lymphocytes .
18448457	0	CD4	0,3	CD45	36,40	CD4	CD45	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	hyper-responsiveness|compound|START_ENTITY hyper-responsiveness|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	CD4 + T cell hyper-responsiveness in CD45 transgenic_mice is independent of isoform .
1968425	0	CD4	78,81	CD45	23,27	CD4	CD45	920	5788	Gene	Gene	proliferation|compound|START_ENTITY stimulation|nmod|proliferation inhibit|dobj|stimulation inhibit|nsubj|antibodies antibodies|appos|END_ENTITY	Anti-leucocyte common -LRB- CD45 -RRB- antibodies inhibit dendritic cell stimulation of CD4 and CD8 T-lymphocyte proliferation .
1969461	0	CD4	12,15	CD45	16,20	CD4	CD45	920	5788	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Decrease of CD4 + CD45 + T-cells in chronic-progressive multiple_sclerosis .
20093141	0	CD4	95,98	CD45	14,18	CD4	CD45	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	+|compound|START_ENTITY responses|nmod|+ correlates|nmod|responses correlates|nsubj|Expression Expression|nmod|isoforms isoforms|nummod|END_ENTITY	Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4 + and CD8 + T cells .
2144259	0	CD4	7,10	CD45	134,138	CD4	CD45	920	5788	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|isoforms isoforms|nmod|leucocyte_common_antigen leucocyte_common_antigen|appos|END_ENTITY	Memory CD4 + T cells in man form two distinct subpopulations , defined by their expression of isoforms of the leucocyte_common_antigen , _ CD45 .
26345973	0	CD4	40,43	CD45	45,49	CD4	CD45	920	5788	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Expression and clinical significance of CD4 + CD45 + peripheral blood T cells in patients with ulcerative_colitis .
26345973	0	CD4	40,43	CD45	45,49	CD4	CD45	920	5788	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Expression and clinical significance of CD4 + CD45 + peripheral blood T cells in patients with ulcerative_colitis .
7851017	0	CD4	0,3	CD45	43,47	CD4	CD45	920	5788	Gene	Gene	subsets|compound|START_ENTITY defined|nsubj|subsets defined|nmod|isoforms isoforms|nmod|END_ENTITY	CD4 + T cell subsets defined by isoforms of CD45 in primary_biliary_cirrhosis .
7908636	0	CD4	63,66	CD45	24,28	CD4	CD45	920	5788	Gene	Gene	+|compound|START_ENTITY signalling|nmod|+ involvement|acl|signalling involvement|nmod|END_ENTITY	Distinct involvement of CD45 in antigen receptor signalling in CD4 + and CD8 + primary T cells .
8041724	0	CD4	109,112	CD45	38,42	CD4	CD45	920	5788	Gene	Gene	thymocytes|compound|START_ENTITY differentiation|nmod|thymocytes regulate|dobj|differentiation regulate|nsubj|Engagement Engagement|nmod|domains domains|nmod|phosphatase phosphatase|compound|END_ENTITY	Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4 + CD8 + thymocytes into mature T cells .
8292053	0	CD4	54,57	CD45	24,28	CD4	CD45	920	5788	Gene	Gene	require|dobj|START_ENTITY require|nsubj|association association|nmod|END_ENTITY	The association between CD45 and lck does not require CD4 or CD8 and is independent of T cell receptor stimulation .
8733112	0	CD4	28,31	CD45	0,4	CD4	CD45	920	5788	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ isoforms|dobj|expression isoforms|nsubj|END_ENTITY	CD45 isoforms expression on CD4 + and CD8 + T cells throughout life , from newborns to centenarians : implications for T cell memory .
8757221	0	CD4	23,26	CD45	0,4	CD4	CD45	920	5788	Gene	Gene	subsets|compound|START_ENTITY isoforms|nmod|subsets isoforms|nsubj|END_ENTITY	CD45 isoforms on human CD4 + T-cell subsets .
8946597	0	CD4	28,31	CD45	0,4	CD4	CD45	920	5788	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	CD45 isoforms expression on CD4 + and CD8 + peripheral blood T-lymphocytes is related to auto-immune processes and hematological manifestations in systemic_lupus_erythematosus .
9366400	0	CD4	0,3	CD45	65,69	CD4	CD45	920	5788	Gene	Gene	thymocytes|compound|START_ENTITY induced|nsubjpass|thymocytes induced|xcomp|die die|dobj|cross-linking cross-linking|compound|END_ENTITY	CD4 + CD8 + thymocytes are preferentially induced to die following CD45 cross-linking , through a novel apoptotic pathway .
9402849	0	CD4	121,124	CD45	104,108	CD4	CD45	920	5788	Gene	Gene	blood|compound|START_ENTITY isoforms|nmod|blood isoforms|nummod|END_ENTITY	Serum levels of interleukin-1_beta , luteinizing hormone , and prolactin correlate with the expression of CD45 isoforms on CD4 + peripheral blood T lymphocytes in healthy women .
9501032	0	CD4	129,132	CD45	136,140	CD4	CD45	920	5788	Gene	Gene	domain|nmod|START_ENTITY determining|dobj|domain determining|nmod|expressing expressing|compound|END_ENTITY	Inhibition of HIV-1 replication by a monoclonal antibody directed toward the complementarity determining region 3-like domain of CD4 in CD45 expressing and CD45-deficient cells .
9874504	0	CD4	72,75	CD45	43,47	CD4	CD45	920	5788	Gene	Gene	lymphocytes|compound|START_ENTITY circulating|dobj|lymphocytes isoforms|acl|circulating isoforms|nummod|END_ENTITY	Distribution of alloreactivity amongst the CD45 isoforms of circulating CD4 and CD8 T lymphocytes .
11385612	0	CD4	44,47	CD45R	20,25	CD4	CD45R	920	5788	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Both CD45R -LRB- low -RRB- and CD45R -LRB- high -RRB- `` revertant '' CD4 memory T cells provide help for memory B cells .
1388189	0	CD4	28,31	CD45R	54,59	CD4	CD45R	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY requirements|nmod|cells requirements|acl|differing differing|nmod|expression expression|compound|END_ENTITY	Activation requirements for CD4 + T cells differing in CD45R expression .
1533900	0	CD4	34,37	CD45R	38,43	CD4	CD45R	920	5788	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Antilymphocyte antibodies against CD4 + CD45R + subsets in patients with IgA_nephropathy .
1534263	0	CD4	12,15	CD45R	54,59	CD4	CD45R	920	5788	Gene	Gene	subsets|compound|START_ENTITY Function|nmod|subsets Function|dep|expression expression|nmod|isoforms isoforms|nummod|END_ENTITY	Function of CD4 T cell subsets in vivo : expression of CD45R isoforms .
15493262	0	CD4	76,79	CD45R	88,93	CD4	CD45R	920	5788	Gene	Gene	CDw29|compound|START_ENTITY CDw29|dep|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
1827080	1	CD4	90,93	CD45R	94,99	CD4	CD45R	920	5788	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|compound|END_ENTITY	Association of insulin autoantibodies with CD4 + CD45R + lymphocyte subpopulation in prediabetic subjects .
1836161	0	CD4	90,93	CD45R	8,13	CD4	CD45R	920	5788	Gene	Gene	+|compound|START_ENTITY helper/inducer|appos|+ affects|dobj|helper/inducer affects|nsubj|expression expression|compound|END_ENTITY	Variant CD45R expression with autosomal dominant inheritance affects both helper/inducer -LRB- CD4 + -RRB- and suppressor/cytotoxic -LRB- CD8 + -RRB- T cell populations .
1967994	0	CD4	17,20	CD45R	22,27	CD4	CD45R	920	5788	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Immunoregulatory CD4 + CD45R + suppressor/inducer T lymphocyte subsets and impaired cell-mediated immunity in patients with Down 's _ syndrome .
1978760	0	CD4	44,47	CD45R	29,34	CD4	CD45R	920	5788	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	-LSB- HLA-DR positive T cells and CD45R positive CD4 cells in primary Sj gren 's syndrome -RSB- .
2346723	0	CD4	70,73	CD45R	20,25	CD4	CD45R	920	5788	Gene	Gene	T-cell_leukaemias|compound|START_ENTITY antigens|nmod|T-cell_leukaemias antigens|nsubj|distribution distribution|nmod|END_ENTITY	The distribution of CD45R , CD29 and CD45RO -LRB- UCHL1 -RRB- antigens in mature CD4 positive T-cell_leukaemias .
2479465	0	CD4	30,33	CD45R	34,39	CD4	CD45R	920	5788	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Depletion of T-cells with the CD4 + CD45R + phenotype in lymphocytes that infiltrate subcutaneous metastases of human melanoma .
2524299	0	CD4	50,53	CD45R	37,42	CD4	CD45R	920	5788	Gene	Gene	helper/inducer|compound|START_ENTITY END_ENTITY|nmod|helper/inducer	Predominance of T cells that express CD45R in the CD4 + helper/inducer lymphocyte subset of neonates .
2525435	0	CD4	84,87	CD45R	33,38	CD4	CD45R	920	5788	Gene	Gene	subset|compound|START_ENTITY subset|nmod|subset +|dobj|subset +|nsubj|augmentation augmentation|nmod|END_ENTITY	Concomitant augmentation of CD4 + CD45R + suppressor/inducer subset and diminution of CD4 + CDw29 + helper/inducer subset during rush hyposensitization in hymenoptera venom allergy .
2567241	0	CD4	52,55	CD45R	32,37	CD4	CD45R	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY distinguishes|dobj|populations distinguishes|nsubj|antibody antibody|nmod|END_ENTITY	A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines .
2968811	0	CD4	140,143	CD45R	20,25	CD4	CD45R	920	5788	Gene	Gene	lymphoproliferative_disorders|compound|START_ENTITY finding|nmod|lymphoproliferative_disorders finding|nsubj|Distribution Distribution|nmod|antigen antigen|compound|END_ENTITY	Distribution of the CD45R antigen in the maturation of lymphoid and myeloid series : the CD45R negative phenotype is a constant finding in T CD4 positive lymphoproliferative_disorders .
2968811	0	CD4	140,143	CD45R	88,93	CD4	CD45R	920	5788	Gene	Gene	lymphoproliferative_disorders|compound|START_ENTITY finding|nmod|lymphoproliferative_disorders finding|nsubj|Distribution Distribution|nmod|antigen antigen|nmod|maturation maturation|nmod|series series|dep|phenotype phenotype|compound|END_ENTITY	Distribution of the CD45R antigen in the maturation of lymphoid and myeloid series : the CD45R negative phenotype is a constant finding in T CD4 positive lymphoproliferative_disorders .
2970472	0	CD4	18,21	CD45R	23,28	CD4	CD45R	920	5788	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Selective loss of CD4 + CD45R + T cells in peripheral blood of multiple_myeloma patients .
7507305	0	CD4	33,36	CD45R	71,76	CD4	CD45R	920	5788	Gene	Gene	cells|nummod|START_ENTITY infiltrating|dobj|cells Characterization|acl|infiltrating atopic_dermatitis|nsubj|Characterization atopic_dermatitis|xcomp|using using|dobj|antibodies antibodies|compound|END_ENTITY	Characterization of infiltrating CD4 + cells in atopic_dermatitis using CD45R and CD29 monoclonal antibodies .
20921150	0	CD4	25,28	CD46	0,4	CD4	CD46	920	4179	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells engagement|nummod|END_ENTITY	CD46 engagement on human CD4 + T cells produces T regulatory type 1-like regulation of antimycobacterial T cell responses .
26590312	0	CD4	13,16	CD49b	17,22	CD4	CD49b	920	3673	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Cells Cells|compound|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
10586041	0	CD4	23,26	CD5	64,67	CD4	CD5	12504(Tax:10090)	12507(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY lineage|nsubj|regulation lineage|nmod|END_ENTITY	Negative regulation of CD4 lineage development and responses by CD5 .
10640739	0	CD4	100,103	CD5	0,3	CD4	CD5	920	921	Gene	Gene	thymocytes|compound|START_ENTITY activation|nmod|thymocytes up-regulates|nmod|activation up-regulates|nsubj|costimulation costimulation|compound|END_ENTITY	CD5 costimulation up-regulates the signaling to extracellular_signal-regulated_kinase activation in CD4 + CD8 + thymocytes and supports their differentiation to the CD4 lineage .
1382908	0	CD4	56,59	CD5	22,25	CD4	CD5	12504(Tax:10090)	12507(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY arising|nmod|mouse production|acl|arising production|nmod|lymphoma lymphoma|compound|END_ENTITY	IL-10 production in a CD5 + B cell lymphoma arising in a CD4 monoclonal antibody-treated SJL mouse .
18573278	0	CD4	67,70	CD5	0,3	CD4	CD5	12504(Tax:10090)	12507(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY function|nmod|CD25 role|nmod|function T|nsubj|role plays|ccomp|T plays|nsubj|END_ENTITY	CD5 plays an inhibitory role in the suppressive function of murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T -LRB- reg -RRB- cells .
19609976	0	CD4	43,46	CD5	84,87	CD4	CD5	12504(Tax:10090)	12507(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY numbers|nmod|CD25 +|nsubj|numbers +|nmod|absence absence|nmod|signaling signaling|compound|END_ENTITY	Increased numbers of thymic and peripheral CD4 + CD25 + Foxp3 + cells in the absence of CD5 signaling .
25199644	0	CD4	52,55	CD5	21,24	CD4	CD5	920	921	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs Bregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	CD4	70,73	CD5	21,24	CD4	CD5	920	921	Gene	Gene	CXCR5|compound|START_ENTITY CXCR5|dep|Bregs Bregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
2783659	0	CD4	110,113	CD5	97,100	CD4	CD5	920	921	Gene	Gene	lymphoma|appos|START_ENTITY lymphoma|nmod|phenotype phenotype|appos|+ +|dep|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
8658050	0	CD4	85,88	CD5	71,74	CD4	CD5	920	921	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4 + CD8 + thymocytes .
9568615	0	CD4	13,16	CD5	62,65	CD4	CD5	443509(Tax:9940)	443328(Tax:9940)	Gene	Gene	+|compound|START_ENTITY Induction|nmod|+ double|nsubj|Induction double|nmod|cells cells|nummod|END_ENTITY	Induction of CD4 + CD8 + double positive T cells and increase in CD5 + B cells in efferent lymph in sheep infected with Trypanosoma evansi .
16918536	0	CD4	22,25	CD52	0,4	CD4	CD52	920	1043	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|ligation ligation|compound|END_ENTITY	CD52 ligation induces CD4 and CD8 down modulation in vivo and in vitro .
8851300	1	CD4	100,103	CD52	105,109	CD4	CD52	920	1043	Gene	Gene	CD3|dep|START_ENTITY CD3|dep|END_ENTITY	Therapy with monoclonal antibodies to T-cell antigens -LRB- CD3 , CD4 , CD52 -RRB- -RSB- .
16818763	0	CD4	32,35	CD55	18,22	CD4	CD55	920	1604	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Costimulation via CD55 on human CD4 + T cells mediated by CD97 .
10651077	0	CD4	24,27	CD56	28,32	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased CD4 + CD16 + and CD4 + CD56 + T cell subsets in Beh et 's disease .
11167804	0	CD4	31,34	CD56	38,42	CD4	CD56	920	4684	Gene	Gene	CD3|dep|START_ENTITY expansion|nmod|CD3 expansion|parataxis|lymphocytes lymphocytes|nsubj|granular granular|amod|END_ENTITY	Polyclonal expansion of CD3 -LRB- + -RRB- / CD4 -LRB- + -RRB- / CD56 -LRB- + -RRB- large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway .
11174380	0	CD4	5,8	CD56	10,14	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD2 - CD4 + CD56 + hematodermic/hematolymphoid _ malignancy .
11401089	0	CD4	10,13	CD56	14,18	CD4	CD56	920	4684	Gene	Gene	natural_killer_leukemia|compound|START_ENTITY natural_killer_leukemia|compound|END_ENTITY	Agranular CD4 + CD56 + blastic natural_killer_leukemia / lymphoma .
11488062	0	CD4	6,9	CD56	0,4	CD4	CD56	920	4684	Gene	Gene	lymphomas|compound|START_ENTITY morphologically|nsubj|lymphomas +|parataxis|morphologically +|compound|END_ENTITY	CD56 + / CD4 + lymphomas and leukemias are morphologically , immunophenotypically , cytogenetically , and clinically diverse .
11757730	0	CD4	15,18	CD56	20,24	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY Association|nmod|+ Association|parataxis|CD8 CD8|nsubj|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12131152	0	CD4	11,14	CD56	104,108	CD4	CD56	920	4684	Gene	Gene	neoplasm|compound|START_ENTITY originates|nsubj|neoplasm originates|nmod|population population|nmod|cells cells|nummod|END_ENTITY	` Agranular CD4 + CD56 + hematodermic neoplasm ' -LRB- blastic_NK-cell_lymphoma -RRB- originates from a population of CD56 + precursor cells related to plasmacytoid monocytes .
12131152	0	CD4	11,14	CD56	16,20	CD4	CD56	920	4684	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	` Agranular CD4 + CD56 + hematodermic neoplasm ' -LRB- blastic_NK-cell_lymphoma -RRB- originates from a population of CD56 + precursor cells related to plasmacytoid monocytes .
12389632	0	CD4	10,13	CD56	15,19	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|parataxis|cutaneous cutaneous|nsubj|+ +|compound|END_ENTITY	Agranular CD4 + / CD56 + cutaneous neoplasm .
12483012	0	CD4	0,3	CD56	4,8	CD4	CD56	920	4684	Gene	Gene	CD68|compound|START_ENTITY CD68|compound|END_ENTITY	CD4 + CD56 + CD68 + hematopoietic_tumor of probable plasmacytoid monocyte derivation with weak expression of cytoplasmic CD3 .
12591970	0	CD4	7,10	CD56	13,17	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|appos|infiltrate infiltrate|compound|END_ENTITY	Florid CD4 + , CD56 + T-cell infiltrate associated with Herpes_simplex_infection simulating nasal NK - / T-cell_lymphoma .
12688346	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	neoplasia|compound|START_ENTITY neoplasia|compound|END_ENTITY	CD4 + CD56 + neoplasia : clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X. CD4 + CD56 + neoplasia is a rare malignancy of unclarified origin .
12695132	0	CD4	23,26	CD56	29,33	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Skin manifestations in CD4 + , CD56 + malignancies .
12876674	0	CD4	85,88	CD56	89,93	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Plasmacytoid dendritic cells : from the plasmacytoid T-cell to type 2 dendritic cells CD4 + CD56 + malignancies .
12935983	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	malignancies|compound|START_ENTITY malignancies|compound|END_ENTITY	CD4 + CD56 + lineage negative malignancies : a new entity developed from malignant early plasmacytoid dendritic cells .
13130309	0	CD4	8,11	CD56	12,16	CD4	CD56	920	4684	Gene	Gene	malignancy|compound|START_ENTITY malignancy|compound|END_ENTITY	What is CD4 + CD56 + malignancy and how should it be treated ?
14616964	0	CD4	112,115	CD56	33,37	CD4	CD56	920	4684	Gene	Gene	phenotypes|nummod|START_ENTITY association|nmod|phenotypes analysis|dep|association analysis|nmod|T-cell T-cell|compound|END_ENTITY	TCR Vbeta repertoire analysis in CD56 + CD16 -LRB- dim / - -RRB- T-cell large granular lymphocyte leukaemia : association with CD4 single and CD4/CD8 double positive phenotypes .
15048964	0	CD4	73,76	CD56	78,82	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Fine-needle aspiration cytology of blastic natural killer-cell lymphoma -LRB- CD4 + CD56 + hematodermic neoplasm -RRB- .
15107748	0	CD4	31,34	CD56	36,40	CD4	CD56	920	4684	Gene	Gene	leukemia|compound|START_ENTITY leukemia|compound|END_ENTITY	-LSB- Primary cutaneous non T non B CD4 + CD56 + leukemia -LRB- 2 cases -RRB- : an original anatomoclinical syndrome -RSB- .
15358570	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	blastic_tumor_of_the_skin|compound|START_ENTITY blastic_tumor_of_the_skin|compound|END_ENTITY	CD4 + CD56 + blastic_tumor_of_the_skin : cytogenetic observations and further evidence of an origin from plasmocytoid dendritic cells .
15602384	0	CD4	11,14	CD56	16,20	CD4	CD56	920	4684	Gene	Gene	CD123|compound|START_ENTITY CD123|compound|END_ENTITY	-LSB- Agranular CD4 + CD56 + CD123 + hematodermic neoplasm -LRB- blastic_NK-cell_lymphoma -RRB- revealed by cutaneous localization : 2 cases -RSB- .
15660891	0	CD4	73,76	CD56	78,82	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutaneous_tumors as the initial presentation of non-T , non-B , nonmyeloid CD4 + CD56 + hematolymphoid malignancy in an adolescent boy .
15692441	0	CD4	11,14	CD56	16,20	CD4	CD56	920	4684	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	-LSB- Agranular CD4 + CD56 + hematodermic neoplasm : a new case report -RSB- .
15832009	0	CD4	0,3	CD56	4,8	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD56 + lineage negative hematopoietic_neoplasm : so called blastic NK cell lymphoma .
16153467	0	CD4	0,3	CD56	4,8	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD56 + hematodermic_neoplasms bear a plasmacytoid dendritic cell phenotype .
16160468	0	CD4	0,3	CD56	7,11	CD4	CD56	920	4684	Gene	Gene	tumors|nsubj|START_ENTITY tumors|nsubj|malignancies malignancies|amod|END_ENTITY	CD4 -LRB- + -RRB- CD56 -LRB- + -RRB- lineage-negative malignancies are rare tumors of plasmacytoid dendritic cells .
16161251	0	CD4	11,14	CD56	16,20	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|parataxis|-RSB- -RSB-|nsubj|neoplasm neoplasm|compound|END_ENTITY	-LSB- Agranular CD4 + / CD56 + haematodermic neoplasm -LRB- Precursor haematologic neoplasm -RRB- -RSB- .
16434387	0	CD4	18,21	CD56	23,27	CD4	CD56	920	4684	Gene	Gene	hematodermic_neoplasm|compound|START_ENTITY hematodermic_neoplasm|compound|END_ENTITY	Primary cutaneous CD4 + / CD56 + hematodermic_neoplasm -LRB- blastic_NK-cell_lymphoma -RRB- : a report of five cases .
16682521	0	CD4	53,56	CD56	57,61	CD4	CD56	920	4684	Gene	Gene	leukemia|compound|START_ENTITY leukemia|compound|END_ENTITY	Blastic natural killer -LRB- NK -RRB- cell leukemia -LRB- agranular CD4 + CD56 + leukemia -RRB- .
16987271	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|dep|haematodermic haematodermic|dep|+ +|compound|END_ENTITY	CD4 + / CD56 + haematodermic neoplasm : a preculsor haematological neoplasm that frequently first presents in the skin .
16998465	0	CD4	100,103	CD56	105,109	CD4	CD56	920	4684	Gene	Gene	hematodermic_neoplasms|compound|START_ENTITY hematodermic_neoplasms|compound|END_ENTITY	Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4 + CD56 + hematodermic_neoplasms .
17194654	0	CD4	10,13	CD56	15,19	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Childhood CD4 + / CD56 + hematodermic neoplasm : case report and review of the literature .
17227117	0	CD4	10,13	CD56	15,19	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|parataxis|hematodermic_neoplasm hematodermic_neoplasm|nsubj|+ +|compound|END_ENTITY	Agranular CD4 + / CD56 + hematodermic_neoplasm : a distinct entity described in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous_lymphomas .
17284963	1	CD4	89,92	CD56	93,97	CD4	CD56	920	4684	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	We report a case of a 75-year-old man with a cutaneous CD4 + CD56 + hematodermic neoplasm .
17709319	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	CD4 + / CD56 + hematodermic neoplasm -LRB- `` blastic natural killer cell lymphoma '' -RRB- : neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon .
17984695	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	CD4 + / CD56 + hematodermic neoplasm : blastic NK cell lymphoma in a 6-year-old child : report of a case and review of literature .
18005171	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	CD4 + / CD56 + hematodermic_neoplasm : report of a rare variant with a T-cell receptor gene rearrangement .
18091395	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|parataxis|originated originated|nsubj|+ +|compound|END_ENTITY	CD4 + / CD56 + hematodermic neoplasm : presentation of 2 cases and review of the concept of an uncommon tumor originated in plasmacytoid dendritic cells expressing CD123 -LRB- IL-3 receptor alpha -RRB- .
18280345	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD56 + hematodermic/plasmacytoid dendritic_cell_tumor with response to pralatrexate .
1828937	0	CD4	40,43	CD56	103,107	CD4	CD56	920	4684	Gene	Gene	mycosis_fungoides|compound|START_ENTITY skin_lesions|nmod|mycosis_fungoides cells|nmod|skin_lesions cells|acl:relcl|lack lack|dobj|CD57 CD57|appos|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18490770	0	CD4	21,24	CD56	25,29	CD4	CD56	920	4684	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Preferential in situ CD4 + CD56 + T cell activation and expansion within human glioblastoma .
18494823	0	CD4	24,27	CD56	29,33	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY variant|nmod|+ variant|dep|hematodermic_neoplasm hematodermic_neoplasm|compound|END_ENTITY	CD4-negative variant of CD4 + / CD56 + hematodermic_neoplasm : description of three cases .
18499965	0	CD4	14,17	CD56	19,23	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Hematodermic CD4 + CD56 + neoplasm in childhood -RSB- .
19094843	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	Hematodermic_neoplasm|compound|START_ENTITY Hematodermic_neoplasm|compound|END_ENTITY	CD4 + / CD56 + Hematodermic_neoplasm -LRB- plasmacytoid dendritic cell tumor -RRB- .
19155730	0	CD4	0,3	CD56	6,10	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|appos|mycosis_fungoides mycosis_fungoides|nummod|END_ENTITY	CD4 + , CD56 + mycosis_fungoides : case report and review of the literature .
19328310	0	CD4	62,65	CD56	72,76	CD4	CD56	920	4684	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	-LSB- Two cases of subcutaneous panniculitis-like T-cell_lymphoma -LRB- CD4 - CD8 + CD56 - -RRB- -RSB- .
19508475	0	CD4	14,17	CD56	18,22	CD4	CD56	920	4684	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	Haematodermic CD4 + CD56 + neoplasm : complete remission after methotrexate-asparaginase treatment .
20409415	0	CD4	10,13	CD56	15,19	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY case|nmod|+ case|dep|+ +|compound|END_ENTITY	A case of CD4 + / CD56 + hematodermic_neoplasm -LRB- plasmacytoid dendritic_cell_neoplasm -RRB- .
20541283	0	CD4	10,13	CD56	15,19	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutaneous CD4 + CD56 + hematologic_malignancies .
20548910	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	START_ENTITY|parataxis|+ +|compound|END_ENTITY	CD4 - / CD56 + / CD123 + Hematodermic Neoplasm Showing Early Liver Metastasis .
21079332	0	CD4	10,13	CD56	15,19	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|dep|neoplasm neoplasm|compound|END_ENTITY	Cutaneous CD4 + / CD56 + hematodermic neoplasm .
21741423	0	CD4	100,103	CD56	13,17	CD4	CD56	920	4684	Gene	Gene	T-cell|compound|START_ENTITY mechanism|nmod|T-cell vitro|dep|mechanism depletion|amod|vitro Induction|nmod|depletion Induction|nmod|cells cells|nummod|END_ENTITY	Induction of CD56 + T cells after prolonged activation of T cells in vitro : a possible mechanism for CD4 + T-cell depletion in acquired immune_deficiency_syndrome patients .
22384114	0	CD4	67,70	CD56	16,20	CD4	CD56	920	4684	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|amod|Cytotoxicity Cytotoxicity|nmod|NK NK|compound|END_ENTITY	Cytotoxicity of CD56 -LRB- bright -RRB- NK cells towards autologous activated CD4 + T cells is mediated through NKG2D , LFA-1 and TRAIL and dampened via CD94/NKG2A .
22838092	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	CD4 + CD56 + hematodermic neoplasm and plasmacytoid dendritic cell tumor : case report and review of the literature .
25332519	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	Hematodermic_Neoplasm|compound|START_ENTITY Hematodermic_Neoplasm|compound|END_ENTITY	CD4 + CD56 + Hematodermic_Neoplasm Without Cutaneous Involvement .
7511637	0	CD4	54,57	CD56	58,62	CD4	CD56	920	4684	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Selective expansion of cytotoxic T lymphocytes with a CD4 + CD56 + surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis_B_virus .
8645884	0	CD4	10,13	CD56	14,18	CD4	CD56	920	4684	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Homing of CD4 + CD56 + T lymphocytes into kidney allografts during tubular_necrosis or rejection .
8752917	0	CD4	22,25	CD56	26,30	CD4	CD56	920	4684	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel population of CD4 + CD56 + myelin-reactive T cells lyses target cells expressing CD56/neural cell adhesion molecule .
9790118	0	CD4	6,9	CD56	12,16	CD4	CD56	920	4684	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	CD2 - , CD4 + , CD56 + agranular natural killer cell lymphoma of the skin .
9989839	0	CD4	0,3	CD56	5,9	CD4	CD56	920	4684	Gene	Gene	neoplasms|compound|START_ENTITY neoplasms|compound|END_ENTITY	CD4 + CD56 + cutaneous neoplasms : a distinct hematological entity ?
11757730	0	CD4	15,18	CD57	26,30	CD4	CD57	920	27087	Gene	Gene	+|compound|START_ENTITY Association|nmod|+ Association|parataxis|CD8 CD8|dep|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
16353293	0	CD4	47,50	CD57	52,56	CD4	CD57	920	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cytokine gene expression profile distinguishes CD4 + / CD57 + T cells of the nodular lymphocyte predominance type of Hodgkin 's _ lymphoma from their tonsillar counterparts .
1828937	0	CD4	40,43	CD57	109,113	CD4	CD57	920	27087	Gene	Gene	mycosis_fungoides|compound|START_ENTITY skin_lesions|nmod|mycosis_fungoides cells|nmod|skin_lesions cells|acl:relcl|lack lack|dobj|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
21491089	0	CD4	38,41	CD57	42,46	CD4	CD57	920	27087	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Altered cytokine levels and increased CD4 + CD57 + T cells in the peripheral blood of hepatitis_C_virus-related hepatocellular_carcinoma patients .
21491089	8	CD4	1299,1302	CD57	1303,1307	CD4	CD57	920	27087	Gene	Gene	abTCR|compound|START_ENTITY abTCR|compound|END_ENTITY	The percentage of CD4 + CD57 + abTCR + cells -LRB- CD4 + CD57 + T cells -RRB- in peripheral blood lymphocytes -LRB- PBLs -RRB- increased with tumor progression .
24291117	0	CD4	72,75	CD57	9,13	CD4	CD57	920	27087	Gene	Gene	responders|nummod|START_ENTITY numbers|nmod|responders associated|nmod|numbers associated|nsubjpass|END_ENTITY	Elevated CD57 and CD95 expressions are associated with lower numbers of CD4 ____ recent_thymic_emigrants_in_HIV-1_infected immune responders following antiretroviral treatment .
7541727	0	CD4	0,3	CD57	4,8	CD4	CD57	920	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD57 + T cells derived from peripheral blood do not support immunoglobulin production by B cells .
9013995	0	CD4	28,31	CD57	32,36	CD4	CD57	920	27087	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Clonal expansion within the CD4 + CD57 + and CD8 + CD57 + T cell subsets in chronic_lymphocytic_leukemia .
9108401	0	CD4	12,15	CD57	17,21	CD4	CD57	920	27087	Gene	Gene	expansions|compound|START_ENTITY expansions|compound|END_ENTITY	Oligoclonal CD4 + CD57 + T-cell expansions contribute to the imbalanced T-cell receptor repertoire of rheumatoid_arthritis patients .
16301611	0	CD4	47,50	CD59a	21,26	CD4	CD59a	12504(Tax:10090)	12509(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Cutting edge : murine CD59a modulates antiviral CD4 + T cell activity in a complement-independent manner .
11123285	0	CD4	113,116	CD62E	76,81	CD4	CD62E	920	6401	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|appos|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
11979045	0	CD4	48,51	CD62L	98,103	CD4	CD62L	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ interleukin-10|nmod|generation role|nmod|interleukin-10 +|nsubj|role +|parataxis|expressing expressing|dobj|phenotype phenotype|amod|+ +|dep|END_ENTITY	The role of interleukin-10 in the generation of CD4 + and CD8 + memory_T cells -LRB- expressing a CD44 + , CD62L - phenotype -RRB- and their contribution to the regulation of immunoglobulin E antibody formation .
12355444	0	CD4	77,80	CD62L	51,56	CD4	CD62L	12504(Tax:10090)	6402	Gene	Gene	cells|compound|START_ENTITY L-selectin|nmod|cells L-selectin|appos|END_ENTITY	Inhibition of TCR-mediated shedding of L-selectin -LRB- CD62L -RRB- on human and mouse CD4 + T cells by metalloproteinase inhibition : analysis of the regulation of Th1/Th2 function .
12496379	0	CD4	79,82	CD62L	26,31	CD4	CD62L	920	6402	Gene	Gene	cells|nummod|START_ENTITY Cutting|nsubj|cells Cutting|dobj|edge edge|dep|expression expression|appos|END_ENTITY	Cutting edge : L-selectin -LRB- CD62L -RRB- expression distinguishes small resting memory CD4 + T cells that preferentially respond to recall antigen .
12571422	0	CD4	83,86	CD62L	76,81	CD4	CD62L	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A new model of chronic_colitis in SCID mice induced by adoptive transfer of CD62L + CD4 + T cells : insights into the regulatory role of interleukin-6 on apoptosis .
15546950	0	CD4	33,36	CD62L	9,14	CD4	CD62L	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subpopulation|nmod|cells subpopulation|compound|END_ENTITY	Only the CD62L + subpopulation of CD4 + CD25 + regulatory T cells protects from lethal acute GVHD .
16378987	0	CD4	80,83	CD62L	73,78	CD4	CD62L	920	6402	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	R5 variants of human_immunodeficiency_virus_type_1 preferentially infect CD62L - CD4 + T cells and are potentially resistant to nucleoside reverse transcriptase inhibitors .
17627234	0	CD4	84,87	CD62L	104,109	CD4	CD62L	920	6402	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4 + CD25 + GITR+F oxp3 + CD62L + functional regulatory T-cells in patients with graft-versus-host_disease .
18977182	0	CD4	62,65	CD62L	77,82	CD4	CD62L	920	6402	Gene	Gene	CD45RA|compound|START_ENTITY alterations|nmod|CD45RA childhood|dep|alterations T|nmod|childhood T|nsubj|END_ENTITY	Thymectomy in early childhood : significant alterations of the CD4 -LRB- + -RRB- CD45RA -LRB- + -RRB- CD62L -LRB- + -RRB- T cell compartment in later life .
19462221	0	CD4	29,32	CD62L	14,19	CD4	CD62L	920	6402	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Expression of CD62L on donor CD4 -LRB- + -RRB- T cells in allografts : correlation with graft-versus-host_disease after unmanipulated allogeneic blood and marrow transplantation .
19766669	0	CD4	51,54	CD62L	0,5	CD4	CD62L	407098(Tax:9913)	6402	Gene	Gene	subset|nmod|START_ENTITY defines|dobj|subset defines|nsubj|END_ENTITY	CD62L defines a subset of pathogen-specific bovine CD4 with central memory cell characteristics .
19919293	0	CD4	8,11	CD62L	27,32	CD4	CD62L	920	6402	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Role of CD4 + CD25 + highFoxp3 + CD62L + regulatory T cells and invariant NKT cells in human allogeneic hematopoietic stem cell transplantation .
23319734	0	CD4	102,105	CD62L	81,86	CD4	CD62L	920	6402	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4 + T lymphocytes .
23747992	0	CD4	25,28	CD62L	18,23	CD4	CD62L	920	6402	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Increased CD45RO + CD62L + CD4 + T-cell subpopulation responsible for Th2 response in Kimura 's _ disease .
25330112	0	CD4	98,101	CD62L	53,58	CD4	CD62L	920	6402	Gene	Gene	Cells|compound|START_ENTITY Suppression|nmod|Cells Suppression|nmod|Activity Activity|nmod|END_ENTITY	Suppression of Foxo1 Activity and Down-Modulation of CD62L -LRB- L-Selectin -RRB- in HIV-1 Infected Resting CD4 T Cells .
26518933	0	CD4	40,43	CD62L	65,70	CD4	CD62L	920	6402	Gene	Gene	CD25|nsubj|START_ENTITY CD25|dobj|END_ENTITY	Activated Regulatory T Cells Expressing CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD45RO -LRB- + -RRB- CD62L -LRB- + -RRB- Biomarkers Could Be a Risk Factor in Liver Allograft Rejection .
26693907	0	CD4	19,22	CD62L	73,78	CD4	CD62L	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Freeze|nmod|Foxp3 +|nsubj|Freeze +|nmod|Loss Loss|nmod|Expression Expression|compound|END_ENTITY	Freeze and Thaw of CD4 + CD25 + Foxp3 + Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host_Disease .
7529973	0	CD4	40,43	CD62L	44,49	CD4	CD62L	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	homing|compound|START_ENTITY homing|compound|END_ENTITY	Steroid receptor-mediated modulation of CD4 + CD62L + cell homing .
8698378	0	CD4	91,94	CD62L	26,31	CD4	CD62L	920	6402	Gene	Gene	cells|compound|START_ENTITY discriminates|dobj|cells discriminates|nsubj|Expression Expression|appos|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
10397327	0	CD4	36,39	CD69	13,17	CD4	CD69	920	969	Gene	Gene	+|compound|START_ENTITY antigen|nmod|+ antigen|nummod|END_ENTITY	Induction of CD69 antigen on normal CD4 + and CD8 + lymphocyte subsets and its relationship with the phenotype of responding T-cells .
11328741	0	CD4	30,33	CD69	0,4	CD4	CD69	920	969	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD69 expression on peripheral CD4 + T cells parallels disease activity and is reduced by mycophenolate_mofetil therapy in uveitis .
12507400	0	CD4	31,34	CD69	63,67	CD4	CD69	920	969	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|expression expression|compound|END_ENTITY	Evaluation of peripheral blood CD4 and CD8 lymphocyte subsets , CD69 expression and histologic rejection grade as diagnostic markers for the presence of cardiac allograft rejection .
15642992	0	CD4	19,22	CD69	0,4	CD4	CD69	920	969	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	CD69 expression on CD4 + T lymphocytes after in vitro stimulation with tuberculin is an indicator of immune sensitization against Mycobacterium_tuberculosis antigens .
16396693	0	CD4	49,52	CD69	20,24	CD4	CD69	920	969	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nsubj|effect effect|nmod|END_ENTITY	Prolactin effect on CD69 and CD154 expression by CD4 + cells from systemic_lupus_erythematosus patients .
19109141	0	CD4	6,9	CD69	0,4	CD4	CD69	12504(Tax:10090)	12515(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	CD69 + CD4 + CD25 - T cells , a new subset of regulatory T cells , suppress T cell proliferation through membrane-bound TGF-beta_1 .
19670272	0	CD4	92,95	CD69	68,72	CD4	CD69	920	969	Gene	Gene	cell|compound|START_ENTITY molecules|nmod|cell molecules|amod|END_ENTITY	AFM - and NSOM-based force spectroscopy and distribution analysis of CD69 molecules on human CD4 + T cell membrane .
20400202	0	CD4	36,39	CD69	72,76	CD4	CD69	12504(Tax:10090)	12515(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY treatment|nmod|cells restores|nsubj|treatment restores|dobj|expression expression|compound|END_ENTITY	Ex vivo enzymatic treatment of aged CD4 T cells restores antigen-driven CD69 expression and proliferation in mice .
20696642	0	CD4	37,40	CD69	15,19	CD4	CD69	920	969	Gene	Gene	Cla|compound|START_ENTITY up-regulation|nmod|Cla up-regulation|nummod|END_ENTITY	Association of CD69 up-regulation on CD4 + Cla + T cells versus patch test , strip patch test and clinical history in nickel sensitization .
22250092	0	CD4	65,68	CD69	0,4	CD4	CD69	12504(Tax:10090)	12515(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signals|nmod|cells regulates|dobj|signals regulates|nsubj|END_ENTITY	CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential .
22252752	0	CD4	171,174	CD69	99,103	CD4	CD69	920	969	Gene	Gene	+|compound|START_ENTITY markers|nmod|+ expression|appos|markers expression|nmod|+ +|nummod|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
22507356	0	CD4	18,21	CD69	29,33	CD4	CD69	920	969	Gene	Gene	CD25|compound|START_ENTITY frequency|nmod|CD25 frequency|dep|T T|compound|END_ENTITY	High frequency of CD4 + CD25 - CD69 + T cells is correlated with a low risk of acute_graft-versus-host_disease in allotransplants .
26869766	0	CD4	114,117	CD69	127,131	CD4	CD69	12504(Tax:10090)	12515(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY inhibition|nmod|CD25 magnesium_isoglycyrrhizinate|nmod|inhibition proliferation|amod|magnesium_isoglycyrrhizinate proliferation|compound|END_ENTITY	Amelioration of concanavalin A-induced autoimmune_hepatitis by magnesium_isoglycyrrhizinate through inhibition of CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- CD69 -LRB- + -RRB- subset proliferation .
8972737	0	CD4	20,23	CD69	168,172	CD4	CD69	12504(Tax:10090)	12515(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY Unresponsiveness|nmod|cells due|nsubj|Unresponsiveness due|nmod|CD8 CD8|dep|immunosuppression immunosuppression|dep|analysis analysis|nmod|END_ENTITY	Unresponsiveness of CD4 + T cells from a non-responder strain to HgCl2 is not due to CD8 -LRB- + -RRB- - mediated immunosuppression : an analysis of the very early activation antigen CD69 .
9605996	0	CD4	100,103	CD69	73,77	CD4	CD69	920	969	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	A whole-blood assay for qualitative and semiquantitative measurements of CD69 surface expression on CD4 and CD8 T lymphocytes using flow cytometry .
9686587	0	CD4	12,15	CD69	61,65	CD4	CD69	12504(Tax:10090)	12515(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|dep|expressing expressing|dobj|END_ENTITY	A subset of CD4 + T cells expressing early activation antigen CD69 in murine lupus : possible abnormal regulatory role for cytokine imbalance .
10421055	0	CD4	49,52	CD7	53,56	CD4	CD7	920	924	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Genotypic , phenotypic and functional analysis of CD4 + CD7 + and CD4 + CD7 - T lymphocyte subsets in S __ zary_syndrome .
10620124	0	CD4	0,3	CD7	7,10	CD4	CD7	920	924	Gene	Gene	T|compound|START_ENTITY T|dep|END_ENTITY	CD4 + / CD7 - T cell frequency and polymerase chain reaction-based clonality assay correlate with stage in cutaneous_T_cell_lymphomas .
11550091	0	CD4	21,24	CD7	4,7	CD4	CD7	920	924	Gene	Gene	memory|compound|START_ENTITY subset|nmod|memory subset|compound|END_ENTITY	The CD7 -LRB- - -RRB- subset of CD4 -LRB- + -RRB- memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 -LRB- IL-15 -RRB- .
12148887	0	CD4	31,34	CD7	39,42	CD4	CD7	920	924	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Spontaneous IL-8 production by CD4 -LRB- + -RRB- , CD7 -LRB- + -RRB- leukemia cells in erythrodermic_S __ zary_syndrome .
12950240	0	CD4	19,22	CD7	24,27	CD4	DC2	920	116255	Gene	Gene	CD56|compound|START_ENTITY CD56|compound|END_ENTITY	An unusual case of CD4 + CD7 + CD56 + acute_leukemia with overlapping features of type 2 dendritic cell -LRB- DC2 -RRB- and myeloid/NK cell precursor acute_leukemia .
1375001	0	CD4	100,103	CD7	94,97	CD4	CD7	920	924	Gene	Gene	-|compound|START_ENTITY +|appos|- +|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
14707048	0	CD4	37,40	CD7	0,3	CD4	CD7	12504(Tax:10090)	12516(Tax:10090)	Gene	Gene	+|compound|START_ENTITY required|nmod|+ required|nsubjpass|END_ENTITY	CD7 and CD28 are required for murine CD4 + CD25 + regulatory T cell homeostasis and prevention of thyroiditis .
17287851	0	CD4	28,31	CD7	125,128	CD4	CD7	920	924	Gene	Gene	line|compound|START_ENTITY HTLV-I_infection|nmod|line leads|nsubj|HTLV-I_infection leads|nmod|alteration alteration|nmod|influx influx|acl:relcl|results results|nmod|loss loss|nmod|expression expression|compound|END_ENTITY	HTLV-I_infection of WE17/10 CD4 + cell line leads to progressive alteration of Ca2 + influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation .
21205081	0	CD4	90,93	CD7	64,67	CD4	CD7	920	924	Gene	Gene	T|compound|START_ENTITY subpopulation|nmod|T cells|amod|subpopulation enriched|dobj|cells enriched|nmod|END_ENTITY	Leukemic_T cells are specifically enriched in a unique CD3 -LRB- dim -RRB- CD7 -LRB- low -RRB- subpopulation of CD4 -LRB- + -RRB- T cells in acute-type adult_T-cell_leukemia .
2783659	0	CD4	110,113	CD7	89,92	CD4	CD7	920	924	Gene	Gene	lymphoma|appos|START_ENTITY lymphoma|nmod|phenotype phenotype|appos|+ +|compound|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
2783859	0	CD4	6,9	CD7	0,3	CD4	CD7	920	924	Gene	Gene	-|compound|START_ENTITY +|appos|- +|compound|END_ENTITY	CD7 + , CD4 - , CD8 - acute leukemia : a syndrome of malignant pluripotent lymphohematopoietic cells .
8973627	0	CD4	78,81	CD7	4,7	CD4	CD7	920	924	Gene	Gene	CD45RA|compound|START_ENTITY represents|nmod|CD45RA END_ENTITY|dep|represents	The CD7 - T cell subset represents the majority of IL-5-secreting cells within CD4 + CD45RA - T cells .
16920932	0	CD4	24,27	CD70	16,20	CD4	CD70	12504(Tax:10090)	21948(Tax:10090)	Gene	Gene	cell-dependent|compound|START_ENTITY Requirement|nmod|cell-dependent Requirement|nmod|END_ENTITY	Requirement for CD70 in CD4 + Th cell-dependent and innate receptor-mediated CD8 + T cell priming .
17615291	0	CD4	99,102	CD70	0,4	CD4	CD70	12504(Tax:10090)	21948(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells induce|dobj|expression +|ccomp|induce +|nsubj|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
19952354	0	CD4	100,103	CD70	0,4	CD4	CD70	12504(Tax:10090)	21948(Tax:10090)	Gene	Gene	T|compound|START_ENTITY CD40-independent|appos|T immunogenicity|nmod|CD40-independent role|nmod|immunogenicity plays|dobj|role plays|nsubj|expression expression|nummod|END_ENTITY	CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent , CD4 + T cell-dependent , licensed CD8 + T cell responses .
20201989	0	CD4	117,120	CD70	103,107	CD4	CD70	920	970	Gene	Gene	T-cell|compound|START_ENTITY stimulation|nmod|T-cell stimulation|nmod|END_ENTITY	Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4 -LRB- + -RRB- T-cell differentiation .
20201989	0	CD4	117,120	CD70	24,28	CD4	CD70	920	970	Gene	Gene	T-cell|compound|START_ENTITY stimulation|nmod|T-cell stimulation|nmod|induction induction|compound|END_ENTITY	Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4 -LRB- + -RRB- T-cell differentiation .
20223637	0	CD4	124,127	CD70	58,62	CD4	CD70	920	970	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Epigenetics and SLE : RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4 + T cells .
20724115	0	CD4	55,58	CD70	38,42	CD4	CD70	920	970	Gene	Gene	cells|nummod|START_ENTITY Hypomethylation|nmod|cells Hypomethylation|nmod|END_ENTITY	Hypomethylation and overexpression of CD70 -LRB- TNFSF7 -RRB- in CD4 + T cells of patients with primary Sj gren 's syndrome .
26462636	0	CD4	47,50	CD70	39,43	CD4	CD70	920	970	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	-LSB- Hypomethylation and overexpression of CD70 in CD4 + T cells of the patients with immuno-related pancytopenia -RSB- .
22252752	0	CD4	171,174	CD71	106,110	CD4	CD71	920	7037	Gene	Gene	+|compound|START_ENTITY markers|nmod|+ expression|appos|markers expression|appos|+ +|compound|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
17082591	0	CD4	36,39	CD73	56,60	CD4	CD73	12504(Tax:10090)	23959(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	T regulatory and primed uncommitted CD4 T cells express CD73 , which suppresses effector CD4 T cells by converting 5 ' - adenosine_monophosphate to adenosine .
17082591	0	CD4	88,91	CD73	56,60	CD4	CD73	12504(Tax:10090)	23959(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppresses|dobj|cells END_ENTITY|acl:relcl|suppresses	T regulatory and primed uncommitted CD4 T cells express CD73 , which suppresses effector CD4 T cells by converting 5 ' - adenosine_monophosphate to adenosine .
21092450	0	CD4	27,30	CD73	19,23	CD4	CD73	920	4907	Gene	Gene	cells|nummod|START_ENTITY -LSB-|nmod|cells -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression of CD73 in CD4 + regulatory T cells in patients with new-onset systemic_lupus_erythematosus -RSB- .
23749427	0	CD4	55,58	CD73	0,4	CD4	CD73	920	4907	Gene	Gene	cells|compound|START_ENTITY derived|nmod|cells vesicles|acl|derived expression|nmod|vesicles expression|nummod|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
24005375	0	CD4	0,3	CD73	6,10	CD4	CD73	920	4907	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 CD73 T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1_infection regardless of viral suppression .
24749746	0	CD4	6,9	CD73	105,109	CD4	CD73	920	4907	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|nmod|exosomes exosomes|nummod|+ +|compound|END_ENTITY	Human CD4 + CD39 + regulatory T cells produce adenosine upon co-expression of surface CD73_or contact with CD73 + exosomes or CD73 + cells .
10064055	0	CD4	44,47	CD8	49,52	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Spontaneous clustering of Thy-1 antigens on CD4 + CD8 + thymocytes lacking TCR engagement by MHC/peptide complexes .
10190907	0	CD4	152,155	CD8	120,123	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY independently|nmod|T independently|nmod:npmod|cells cells|amod|cytotoxicity cytotoxicity|nmod|T T|compound|END_ENTITY	Cytotoxic T lymphocyte-associated antigen 4 -LRB- CTLA-4 -RRB- can regulate dendritic cell-induced activation and cytotoxicity of CD8 -LRB- + -RRB- T cells independently of CD4 -LRB- + -RRB- T cell help .
10203105	0	CD4	26,29	CD8	31,34	CD4	CD8	920	925	Gene	Gene	proliferation|nmod|START_ENTITY proliferation|dep|cells cells|compound|END_ENTITY	Abnormal proliferation of CD4 - CD8 + gammadelta + T cells with chromosome 6 anomaly : role of Fas_ligand expression in spontaneous regression of the cells .
10206260	0	CD4	89,92	CD8	54,57	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY alternative|nmod|+ lymphocyte|amod|alternative molecules|nmod|lymphocyte molecules|nummod|END_ENTITY	Evaluation of a quantitative determination of CD4 and CD8 molecules as an alternative to CD4 + and CD8 + T lymphocyte counts in Africans .
10370378	0	CD4	48,51	CD8	52,55	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Effects of SIVmac_infection on peripheral blood CD4 + CD8 + T lymphocytes in cynomolgus macaques .
10380839	0	CD4	21,24	CD8	26,29	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Relationship|nmod|+ Relationship|dep|ratio ratio|compound|END_ENTITY	Relationship between CD4 + / CD8 + T cell ratio and T cell activation in systemic_lupus_erythematosus .
10400821	6	CD4	1226,1229	CD8	1231,1234	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	Drug-induced clearance of parasitemia was characterized by a decrease of IL-2 + / IFN-gamma - and type 2 cytokine expressing CD4 - / CD8 - cells and by a gradual increase of IL-10 + / IFN-gamma - expression .
10477611	0	CD4	16,19	CD8	41,44	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|activation activation|compound|END_ENTITY	Requirement for CD4 + T cells in V beta 4 + CD8 + T cell activation associated with latent murine gammaherpesvirus infection .
10510084	0	CD4	87,90	CD8	93,96	CD4	CD8	920	925	Gene	Gene	thymocytes|amod|START_ENTITY thymocytes|amod|END_ENTITY	Receptor avidity and costimulation specify the intracellular Ca2 + signaling pattern in CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes .
10549630	0	CD4	61,64	CD8	25,28	CD4	CD8	920	925	Gene	Gene	cell|compound|START_ENTITY reverses|nmod|cell reverses|dobj|tolerance tolerance|compound|END_ENTITY	CTLA-4 blockade reverses CD8 + T cell tolerance to tumor by a CD4 + T cell - and IL-2-dependent mechanism .
10599998	0	CD4	18,21	CD8	94,97	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Co-cultivation|nmod|+ leads|nsubj|Co-cultivation leads|nmod|appearance appearance|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Co-cultivation of CD4 + and CD8 + human T-cells leads to the appearance of CD4 cells expressing CD8 through de novo synthesis of the CD8_alpha-subunit .
10599998	0	CD4	73,76	CD8	94,97	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	Co-cultivation of CD4 + and CD8 + human T-cells leads to the appearance of CD4 cells expressing CD8 through de novo synthesis of the CD8_alpha-subunit .
10640739	0	CD4	100,103	CD8	104,107	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	CD5 costimulation up-regulates the signaling to extracellular_signal-regulated_kinase activation in CD4 + CD8 + thymocytes and supports their differentiation to the CD4 lineage .
10640771	0	CD4	14,17	CD8	207,210	CD4	CD8	920	925	Gene	Gene	response|compound|START_ENTITY 60|dep|response overlap|dep|60 overlap|nmod|epitope epitope|compound|END_ENTITY	Multispecific CD4 + T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia_enterocolitica in Yersinia-triggered reactive_arthritis : overlap with the B27-restricted CD8 epitope , functional properties , and epitope presentation by multiple DR alleles .
10713333	0	CD4	8,11	CD8	12,15	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Unusual CD4 + CD8 + phenotype in a greek patient diagnosed with adult_T-cell_leukemia positive for human_T-cell_leukemia_virus_type_I _ -LRB- HTLV-I -RRB- .
10743519	0	CD4	8,11	CD8	12,15	CD4	CD8	920	925	Gene	Gene	Role|nmod|START_ENTITY Role|dep|ratio ratio|nummod|END_ENTITY	Role of CD4 : CD8 ratio in predicting HIV_co-infection in patients with newly diagnosed tuberculosis .
10761920	0	CD4	55,58	CD8	67,70	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|nmod|fate fate|compound|END_ENTITY	The duration of antigen receptor signalling determines CD4 + versus CD8 + T-cell lineage fate .
10798745	0	CD4	26,29	CD8	59,62	CD4	CD8	920	925	Gene	Gene	anergy|compound|START_ENTITY Induction|nmod|anergy Induction|nmod|CD28 CD28|compound|END_ENTITY	Induction of xenoreactive CD4 + T-cell anergy by suppressor CD8 + CD28 - T cells .
10805728	0	CD4	38,41	CD8	0,3	CD4	CD8	920	925	Gene	Gene	CD8|compound|START_ENTITY extinction|nmod|CD8 extinction|compound|END_ENTITY	CD8 coreceptor extinction in signaled CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes : coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes .
10864680	0	CD4	155,158	CD8	51,54	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY rates|nmod|T-cell patients|nmod|rates cells|nmod|patients decrease|nsubj|cells T|ccomp|decrease T|nsubj|analysis analysis|nmod|activity activity|nmod|END_ENTITY	Quantitative analysis of the antiviral activity of CD8 -LRB- + -RRB- T cells from human immunodeficiency virus-positive asymptomatic patients with different rates of CD4 -LRB- + -RRB- T-cell decrease .
10882415	0	CD4	70,73	CD8	92,95	CD4	CD8	920	925	Gene	Gene	extinction|nummod|START_ENTITY extinction|nmod|T T|compound|END_ENTITY	Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8 -LRB- + -RRB- T cell differentiation in the thymus .
10899249	0	CD4	15,18	CD8	19,22	CD4	CD8	920	925	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|ratio ratio|nummod|END_ENTITY	Correlation of CD4 : CD8 ratio and tumour necrosis factor -LRB- TNF -RRB- alpha levels in induced sputum with bronchoalveolar lavage fluid in pulmonary_sarcoidosis .
10933395	0	CD4	44,47	CD8	131,134	CD4	CD8	920	925	Gene	Gene	+8|compound|START_ENTITY thymocytes|nummod|+8 terminate|nsubj|thymocytes terminate|advcl|differentiating differentiating|nmod|cells cells|compound|END_ENTITY	Coreceptor reversal in the thymus : signaled CD4 +8 + thymocytes initially terminate CD8 transcription even when differentiating into CD8 + T cells .
10933395	0	CD4	44,47	CD8	82,85	CD4	CD8	920	925	Gene	Gene	+8|compound|START_ENTITY thymocytes|nummod|+8 terminate|nsubj|thymocytes terminate|dobj|transcription transcription|compound|END_ENTITY	Coreceptor reversal in the thymus : signaled CD4 +8 + thymocytes initially terminate CD8 transcription even when differentiating into CD8 + T cells .
10942090	0	CD4	11,14	CD8	16,19	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|estimated estimated|nsubj|counts counts|compound|END_ENTITY	Peripheral CD4 + / CD8 + T-lymphocyte counts estimated by an immunocapture method in the normal healthy south Indian adults and HIV seropositive individuals .
11026443	0	CD4	26,29	CD8	31,34	CD4	CD8	920	925	Gene	Gene	Normalization|nmod|START_ENTITY Normalization|dep|remission remission|dep|END_ENTITY	Normalization of elevated CD4 - / CD8 - -LRB- double-negative -RRB- T cells after thymectomy parallels clinical remission in myasthenia_gravis associated with thymic_hyperplasia but not thymoma .
11067895	0	CD4	9,12	CD8	13,16	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Immature CD4 + CD8 + thymocytes do not polarize lipid rafts in response to TCR-mediated signals .
11119431	0	CD4	48,51	CD8	52,55	CD4	CD8	920	925	Gene	Gene	patients|nmod|START_ENTITY Characteristics|nmod|patients Characteristics|dep|normalization normalization|nummod|END_ENTITY	Characteristics of HIV-1-infected patients with CD4 : CD8 lymphocyte ratio normalization on antiretroviral therapy .
11206348	0	CD4	33,36	CD8	38,41	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Distribution of double-negative -LRB- CD4 - CD8 - , DN -RRB- T subsets in blood and synovial_fluid from patients with rheumatoid_arthritis .
11292262	0	CD4	12,15	CD8	16,19	CD4	CD8	920	925	Gene	Gene	START_ENTITY|acl|+ +|dobj|stage stage|nummod|END_ENTITY	The `` early ' CD4 + CD8 + stage of thymocte differentiation hallmarks the end of a strong positive correlation between extracellular matrix receptor expression and protein tyrosine phosphorylation .
11292726	0	CD4	16,19	CD8	23,26	CD4	CD8	920	925	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Reversal of the CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified , water-soluble S3-S4 dimer of pertussis toxin .
11303820	0	CD4	132,135	CD8	158,161	CD4	CD8	920	925	Gene	Gene	count|compound|START_ENTITY increase|nmod|count eradication|nmod|increase eradication|advmod|low low|dep|+ +|nummod|END_ENTITY	Visceral_leishmaniasis in an AIDS patient on successful antiretroviral therapy : failure of parasite eradication despite increase in CD4 + T-cell count but low CD8 + T-cell count .
11342604	0	CD4	58,61	CD8	62,65	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Distinct mechanisms contribute to generate and change the CD4 : CD8 cell ratio during thymus development : a role for the Notch ligand , Jagged1 .
11389959	0	CD4	30,33	CD8	34,37	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Comparative evaluation of the CD4 + CD8 + and CD4 + CD8 - lymphocytes in the immune response to porcine_rubulavirus .
11422033	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD8 + -LRB- thymocyte-like -RRB- T lymphocytes present in blood and skin from patients with atopic_dermatitis suggest immune_dysregulation .
11454056	0	CD4	16,19	CD8	23,26	CD4	CD8	920	925	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|cells cells|compound|END_ENTITY	Upregulation of CD4 on CD8 + T cells : CD4dimCD8bright T cells constitute an activated phenotype of CD8 + T cells .
11454056	0	CD4	16,19	CD8	98,101	CD4	CD8	920	925	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|parataxis|constitute constitute|dobj|phenotype phenotype|nmod|cells cells|compound|END_ENTITY	Upregulation of CD4 on CD8 + T cells : CD4dimCD8bright T cells constitute an activated phenotype of CD8 + T cells .
11466326	0	CD4	51,54	CD8	25,28	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY control|nmod|cells control|nmod|activation activation|compound|END_ENTITY	Cutting edge : control of CD8 + T cell activation by CD4 + CD25 + immunoregulatory cells .
11466356	0	CD4	50,53	CD8	104,107	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells requires|nsubj|function requires|nmod|cells cells|compound|END_ENTITY	Antibody-independent antiviral function of memory CD4 + T cells in vivo requires regulatory signals from CD8 + effector T cells .
11477541	0	CD4	0,3	CD8	6,9	CD4	CD8	920	925	Gene	Gene	thymocytes|nsubj|START_ENTITY thymocytes|nsubj|TCR TCR|compound|END_ENTITY	CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- TCR -LRB- low -RRB- thymocytes express low levels of glucocorticoid_receptors while being sensitive to glucocorticoid-induced apoptosis .
11479623	0	CD4	90,93	CD8	71,74	CD4	CD8	920	925	Gene	Gene	START_ENTITY|amod|stable stable|dep|END_ENTITY	Differential regulation of antiviral T-cell immunity results in stable CD8 + but declining CD4 + T-cell memory .
11485408	0	CD4	133,136	CD8	167,170	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY independence|compound|T independence|nmod|T T|compound|END_ENTITY	Viral neuraminidase treatment of dendritic cells enhances antigen-specific CD8 -LRB- + -RRB- T cell proliferation , but does not account for the CD4 -LRB- + -RRB- T cell independence of the CD8 -LRB- + -RRB- T cell response during influenza_virus_infection .
11526203	0	CD4	13,16	CD8	37,40	CD4	CD8	920	925	Gene	Gene	Induction|nmod|START_ENTITY T|nsubj|Induction T|ccomp|type type|nsubj|END_ENTITY	Induction of CD4 -LRB- + -RRB- T cell-dependent CD8 -LRB- + -RRB- type 1 responses in humans by a malaria DNA vaccine .
11589307	0	CD4	65,68	CD8	69,72	CD4	CD8	920	925	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Downregulated expression of Ly-6-ThB on developing T cells marks CD4 + CD8 + subset undergoing selection in the thymus .
11594915	0	CD4	23,26	CD8	35,38	CD4	CD8	920	925	Gene	Gene	bright|dep|START_ENTITY cells|amod|bright cells|compound|END_ENTITY	Increase in peripheral CD4 bright + CD8 dull + T cells in Parkinson_disease .
11689637	0	CD4	45,48	CD8	21,24	CD4	CD8	920	925	Gene	Gene	express|dobj|START_ENTITY express|nsubj|lymphocytes lymphocytes|compound|END_ENTITY	Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human_immunodeficiency_virus_type_1 .
11756173	0	CD4	48,51	CD8	14,17	CD4	CD8	920	925	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|Activation Activation|nmod|cells cells|compound|END_ENTITY	Activation of CD8 T cells induces expression of CD4 , which functions as a chemotactic receptor .
11757730	0	CD4	15,18	CD8	32,35	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Association|nmod|+ Association|parataxis|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
11821901	0	CD4	15,18	CD8	62,65	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY crucial|nsubj|cells crucial|nmod|development development|nmod|responses responses|compound|END_ENTITY	IL-4-secreting CD4 + T cells are crucial to the development of CD8 + T-cell responses against malaria liver stages .
11823493	0	CD4	107,110	CD8	82,85	CD4	CD8	920	925	Gene	Gene	CD8|compound|START_ENTITY required|nmod|CD8 required|nmod|development development|nmod|thymocytes thymocytes|amod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11823493	0	CD4	76,79	CD8	113,116	CD4	CD8	920	925	Gene	Gene	thymocytes|amod|START_ENTITY development|nmod|thymocytes required|nmod|development required|nmod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11823493	0	CD4	76,79	CD8	82,85	CD4	CD8	920	925	Gene	Gene	thymocytes|amod|START_ENTITY thymocytes|amod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11867562	0	CD4	106,109	CD8	11,14	CD4	CD8	920	925	Gene	Gene	cytokines|nmod|START_ENTITY induced|nmod|cytokines expression|acl|induced expression|compound|END_ENTITY	Reversible CD8 expression induced by common_cytokine_receptor_gamma_chain-dependent cytokines in a cloned CD4 -LRB- + -RRB- T -LRB- h -RRB- 1 cell line .
11937530	0	CD4	31,34	CD8	89,92	CD4	CD8	920	925	Gene	Gene	activation|compound|START_ENTITY activation|dep|potentiates potentiates|dobj|activation activation|compound|END_ENTITY	In vivo CD86 blockade inhibits CD4 + T cell activation , whereas CD80 blockade potentiates CD8 + T cell activation and CTL effector function .
12023777	0	CD4	111,114	CD8	133,136	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY reservoir|nmod|cells size|nmod|reservoir Relationship|nmod|size Relationship|dep|ratios ratios|compound|END_ENTITY	Relationship between the size of the human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- reservoir in peripheral blood CD4 + T cells and CD4 + : CD8 + T cell ratios in aviremic_HIV-1-infected individuals receiving long-term highly active antiretroviral therapy .
12067759	0	CD4	45,48	CD8	21,24	CD4	CD8	920	925	Gene	Gene	clone|compound|START_ENTITY receptor|nmod|clone receptor|compound|END_ENTITY	Co-expression of the CD8 receptor in a human CD4 + T-cell clone influences proliferation , cytosolic Ca2 + release and cytokine production .
12114403	0	CD4	12,15	CD8	60,63	CD4	CD8	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY Infusion|nmod|lymphocytes induces|nsubj|Infusion induces|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	Infusion of CD4 + donor lymphocytes induces the expansion of CD8 + donor T cells with cytolytic activity directed against recipient hematopoietic cells .
12139944	0	CD4	41,44	CD8	47,50	CD4	CD8	920	925	Gene	Gene	picture|nmod|START_ENTITY END_ENTITY|nsubj|picture	A composite picture of TcR alpha/beta -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T Cells -LRB- alpha/beta-DNTCs -RRB- in humans with autoimmune_lymphoproliferative_syndrome .
12194751	0	CD4	27,30	CD8	35,38	CD4	CD8	920	925	Gene	Gene	ratio|nmod|START_ENTITY effect|nmod|ratio +|nsubj|effect +|nmod|T-cells T-cells|compound|END_ENTITY	The effect of the ratio of CD4 + to CD8 + T-cells on radiation-induced apoptosis in human lymphocyte subpopulations .
12209632	0	CD4	31,34	CD8	0,3	CD4	CD8	920	925	Gene	Gene	absence|nmod|START_ENTITY lethargy|nmod|absence lethargy|nummod|END_ENTITY	CD8 lethargy in the absence of CD4 help .
12366378	0	CD4	43,46	CD8	47,50	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Soluble factor-mediated differentiation of CD4 + CD8 + thymocytes to single positives in vitro .
12421913	0	CD4	14,17	CD8	85,88	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|prevent prevent|dobj|rejection rejection|compound|END_ENTITY	Cutting edge : CD4 + CD25 + alloantigen-specific immunoregulatory cells that can prevent CD8 + T cell-mediated graft rejection : implications for anti-CD154 immunotherapy .
12534590	0	CD4	30,33	CD8	91,94	CD4	CD8	920	925	Gene	Gene	Isolation|nmod|START_ENTITY Isolation|dep|clone clone|nmod|activity activity|nmod|END_ENTITY	Isolation of a CD8alphaalpha + CD4 - tumour T-cell clone with cytotoxic activity from a CD4 + CD8 - cutaneous_T-cell_lymphoma .
12594515	0	CD4	0,3	CD8	64,67	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY required|nsubjpass|cells required|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes .
12626577	0	CD4	0,3	CD8	134,137	CD4	CD8	920	925	Gene	Gene	differentiation|compound|START_ENTITY associated|nsubjpass|differentiation associated|nmod|cells cells|compound|END_ENTITY	CD4 + T cell-induced differentiation of EBV-transformed lymphoblastoid cells is associated with diminished recognition by EBV-specific CD8 + cytotoxic T cells .
12695490	0	CD4	22,25	CD8	109,112	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY role|nmod|T lymphoid|nsubj|role lymphoid|nmod|cells cells|compound|END_ENTITY	Complementary role of CD4 + T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8 + T cells .
12782709	0	CD4	67,70	CD8	113,116	CD4	CD8	920	925	Gene	Gene	help|nummod|START_ENTITY help|nmod|presentation presentation|nmod|cells cells|compound|END_ENTITY	Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8 + T cells : implications for vaccine development in immune-deficient hosts .
12787722	0	CD4	62,65	CD8	11,14	CD4	CD8	920	925	Gene	Gene	clones|compound|START_ENTITY control|dobj|clones control|nsubj|cells cells|compound|END_ENTITY	Regulatory CD8 + T cells control thyrotropin receptor-specific CD4 + clones in healthy subjects .
12791668	0	CD4	26,29	CD8	0,3	CD4	CD8	920	925	Gene	Gene	express|dobj|START_ENTITY cells|acl:relcl|express cells|nummod|END_ENTITY	CD8 + T cells that express CD4 on their surface -LRB- CD4dimCD8bright T cells -RRB- recognize an antigen-specific target , are detected in vivo , and can be productively infected by T-tropic HIV .
12804002	0	CD4	107,110	CD8	111,114	CD4	CD8	920	925	Gene	Gene	count|compound|START_ENTITY count|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12804002	0	CD4	107,110	CD8	47,50	CD4	CD8	920	925	Gene	Gene	count|compound|START_ENTITY +|nmod|count +|nsubj|immunodeficiency_virus_infection immunodeficiency_virus_infection|nmod|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12804002	0	CD4	43,46	CD8	111,114	CD4	CD8	920	925	Gene	Gene	CD8|compound|START_ENTITY immunodeficiency_virus_infection|nmod|CD8 +|nsubj|immunodeficiency_virus_infection +|nmod|count count|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12810689	0	CD4	117,120	CD8	173,176	CD4	CD8	920	925	Gene	Gene	appear|nmod|START_ENTITY Unraveling|parataxis|appear lo|csubj|Unraveling lo|nmod|selection selection|nmod|cells cells|compound|END_ENTITY	Unraveling a revealing paradox : Why major histocompatibility complex I-signaled thymocytes `` paradoxically '' appear as CD4 +8 lo transitional cells during positive selection of CD8 + T cells .
12839958	0	CD4	28,31	CD8	117,120	CD4	CD8	920	925	Gene	Gene	START_ENTITY|acl|+ +|ccomp|enhance enhance|nmod|generation generation|nmod|cells cells|compound|END_ENTITY	P53 -LRB- 110-124 -RRB- - specific human CD4 + T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8 + T cells .
1284651	0	CD4	45,48	CD8	6,9	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY myelin_basic_protein|nsubj|+ autologous|acl:relcl|myelin_basic_protein regulates|dobj|autologous regulates|nsubj|clone clone|compound|END_ENTITY	Human CD8 + T cell clone regulates autologous CD4 + myelin_basic_protein specific T cells .
1321339	0	CD4	42,45	CD8	46,49	CD4	CD8	920	925	Gene	Gene	precursors|compound|START_ENTITY precursors|compound|END_ENTITY	A viral long terminal repeat expressed in CD4 + CD8 + precursors is downregulated in mature peripheral CD4-CD8 + or CD4 + CD8 - T cells .
1347493	0	CD4	91,94	CD8	96,99	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreases in alpha beta T cell receptor negative T cells and CD8 cells , and an increase in CD4 + CD8 + cells in active Hashimoto 's _ disease and subacute_thyroiditis .
1354230	4	CD4	703,706	CD8	707,710	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Furthermore , this decrease in CD4 + CD8 + cells was accompanied by a relative increase in the percentages of CD4 + CD8 - , CD4-CD8 + and CD4-CD8 - cells , whereas their absolute numbers actually reduced on day 4 .
1357752	0	CD4	77,80	CD8	81,84	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Negative selection of precursor thymocytes before their differentiation into CD4 + CD8 + cells .
1363009	0	CD4	37,40	CD8	42,45	CD4	CD8	493775(Tax:9685)	925	Gene	Gene	+|compound|START_ENTITY decrease|nmod|+ decrease|dep|ratio ratio|nummod|END_ENTITY	Immunization-induced decrease of the CD4 + : CD8 + ratio in cats experimentally infected with feline_immunodeficiency_virus .
1375001	0	CD4	100,103	CD8	106,109	CD4	CD8	920	925	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
1387565	0	CD4	99,102	CD8	105,108	CD4	CD8	920	925	Gene	Gene	isolation|nmod|START_ENTITY development|dep|isolation understanding|dobj|development approach|acl|understanding approach|appos|END_ENTITY	A new approach to understanding T cell development : the isolation and characterization of immature CD4 - , CD8 - , CD3 - T cell cDNAs by subtraction cloning .
1387727	0	CD4	45,48	CD8	51,54	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
1421412	0	CD4	139,142	CD8	113,116	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY thymocytes|nsubj|+ mediated|parataxis|thymocytes mediated|nmod|CD4 CD4|compound|END_ENTITY	Enhancement of T-cell-depleted bone marrow allografts in the absence of graft-versus-host disease is mediated by CD8 + CD4 - and not by CD8 - CD4 + thymocytes .
1434032	0	CD4	14,17	CD8	18,21	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- Expansion of CD4 + CD8 + T lymphocytes in the peripheral blood of a patient with pulmonary_tuberculosis -RSB- .
14500656	0	CD4	137,140	CD8	178,181	CD4	CD8	920	925	Gene	Gene	factor|nmod|START_ENTITY reveals|nmod|factor antisense|ccomp|reveals antisense|parataxis|thymocytes thymocytes|nsubj|+ +|compound|END_ENTITY	Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4 - / CD8 + thymocytes .
14500656	0	CD4	173,176	CD8	178,181	CD4	CD8	920	925	Gene	Gene	development|nmod|START_ENTITY silencing|nmod|development reveals|dep|silencing antisense|ccomp|reveals antisense|parataxis|thymocytes thymocytes|nsubj|+ +|compound|END_ENTITY	Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4 - / CD8 + thymocytes .
14562607	0	CD4	73,76	CD8	77,80	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Possible role of genetic factor -LRB- s -RRB- on age-related increase of peripheral CD4 + CD8 + double positive T cells in cynomolgus_monkeys .
14605443	0	CD4	96,99	CD8	11,14	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY correlated|nmod|T activity|acl|correlated counts|nsubj|activity T|xcomp|counts T|nsubj|Ability Ability|nmod|END_ENTITY	Ability of CD8 -LRB- + -RRB- T cell anti-feline immunodeficiency virus activity correlated with peripheral CD4 -LRB- + -RRB- T cell counts and plasma_viremia .
14607920	0	CD4	118,121	CD8	159,162	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|advcl|priming priming|nmod|cells cells|compound|END_ENTITY	Antigenic epitopes fused to cationic peptide bound to oligonucleotides facilitate Toll-like_receptor_9-dependent , but CD4 + T cell help-independent , priming of CD8 + T cells .
14609046	0	CD4	17,20	CD8	23,26	CD4	CD8	920	925	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	A pilot study on CD4 _ CD8 cell counts in healthy HIV seronegative pregnant women .
14611679	0	CD4	0,3	CD8	35,38	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|appos|cells cells|nummod|END_ENTITY	CD4 + T cells in cancer_stroma , not CD8 + T cells in cancer cell nests , are associated with favorable prognosis in human non-small_cell_lung_cancers .
14621007	0	CD4	20,23	CD8	24,27	CD4	CD8	920	925	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|compound|END_ENTITY	Increased thymocyte CD4 + CD8 + cells and T-cell_receptor beta gene rearrangements in thymoma .
14635030	0	CD4	12,15	CD8	41,44	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY required|nsubjpass|cells required|nmod|generation generation|compound|END_ENTITY	Mini-review CD4 T cells are required for CD8 T cell memory generation .
14707745	0	CD4	50,53	CD8	0,3	CD4	CD8	920	925	Gene	Gene	lymphocytes|nummod|START_ENTITY +|nmod|lymphocytes +|nsubj|END_ENTITY	CD8 + tumor-infiltrating lymphocytes together with CD4 + tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic_adenocarcinoma .
14722622	0	CD4	0,3	CD8	77,80	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|suppress suppress|dobj|rejection rejection|acl|mediated mediated|nmod|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress allograft rejection mediated by memory CD8 + T cells via a CD30-dependent mechanism .
14971034	0	CD4	0,3	CD8	53,56	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY guarantee|nsubj|cells guarantee|iobj|fitness fitness|nmod|memory memory|compound|END_ENTITY	CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells .
14975355	0	CD4	147,150	CD8	153,156	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Expression of costimulatory molecules -LRB- CD80 , CD86 , CD28 , CD152 -RRB- , accessory molecules -LRB- TCR alphabeta , TCR gammadelta -RRB- and T cell lineage molecules -LRB- CD4 + , CD8 + -RRB- in PBMC of leprosy patients using Mycobacterium_leprae antigen -LRB- MLCWA -RRB- with murabutide and T cell peptide of Trat protein .
14999599	0	CD4	83,86	CD8	22,25	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY requires|dobj|help requires|nmod|T T|compound|END_ENTITY	In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4 + T cell help .
15031541	4	CD4	535,538	CD8	541,544	CD4	CD8	395362(Tax:9031)	428800(Tax:9031)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The percentage of CD3 -LRB- + -RRB- cells , CD4 -LRB- + -RRB- cells , CD8_alpha -LRB- + -RRB- cells , CD8_beta -LRB- + -RRB- , and CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells was 76 % , 41 % , 14 % , 5 % , and 15 % , respectively .
15033791	0	CD4	0,3	CD8	110,113	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY increases|nummod|+ dependent|nsubj|increases dependent|nmod|inhibition inhibition|nmod|apoptosis apoptosis|compound|END_ENTITY	CD4 + lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8 + cell apoptosis .
1505636	0	CD4	9,12	CD8	13,16	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|ratios ratios|nummod|END_ENTITY	Abnormal CD4 : CD8 ratios and delayed germinal center reconstitution in lymph nodes of human graft recipients with graft-versus-host_disease -LRB- GVHD -RRB- : an immunohistological study .
15117448	0	CD4	60,63	CD8	0,3	CD4	CD8	920	925	Gene	Gene	loss|compound|START_ENTITY predict|dobj|loss predict|nsubj|cells cells|compound|END_ENTITY	CD8 + CD38 + T cells but not HIV_type_1 RNA viral load predict CD4 + T cell loss in a predominantly minority female HIV + adolescent population .
15134772	0	CD4	65,68	CD8	33,36	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY role|nmod|T-cell help|nsubj|role Towards|dep|help Towards|nsubj|definition definition|nmod|memory memory|compound|END_ENTITY	Towards a cellular definition of CD8 + T-cell memory : the role of CD4 + T-cell help in CD8 + T-cell responses .
15134772	0	CD4	65,68	CD8	85,88	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY role|nmod|T-cell help|nsubj|role help|nmod|responses responses|compound|END_ENTITY	Towards a cellular definition of CD8 + T-cell memory : the role of CD4 + T-cell help in CD8 + T-cell responses .
15147571	0	CD4	125,128	CD8	19,22	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY bias|nmod|cells helper|dobj|bias T|parataxis|helper T|nsubj|Aberration Aberration|nmod|memory memory|compound|END_ENTITY	Aberration of CCR7 CD8 memory T cells from patients with systemic_lupus_erythematosus : an inducer of T helper type 2 bias of CD4 T cells .
1516633	0	CD4	107,110	CD8	111,114	CD4	CD8	920	925	Gene	Gene	clone|compound|START_ENTITY clone|compound|END_ENTITY	CD4-class II major histocompatibility complex interaction does not enhance killing by a class I-restricted CD4 + CD8 + cytotoxic T cell clone .
15173593	0	CD4	0,3	CD8	7,10	CD4	CD8	920	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	CD4 on CD8 -LRB- + -RRB- T cells directly enhances effector function and is a target for HIV_infection .
15308119	0	CD4	0,3	CD8	61,64	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY inhibit|nsubj|cells inhibit|dobj|activity activity|nmod|+ +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells inhibit cytotoxic activity of T CD8 + and NK lymphocytes in the direct cell-to-cell interaction .
15331721	0	CD4	84,87	CD8	57,60	CD4	CD8	920	925	Gene	Gene	expressing|dobj|START_ENTITY lymphocytes|xcomp|expressing lymphocytes|nsubj|levels levels|nmod|infection infection|nmod|END_ENTITY	High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo .
1533569	0	CD4	146,149	CD8	152,155	CD4	CD8	920	925	Gene	Gene	+|appos|START_ENTITY +|appos|END_ENTITY	Different sensitivity to interleukin_4 of interleukin_2 - and interferon alpha-induced CD69 antigen expression in human resting NK cells and CD3 + , CD4 - , CD8 - lymphocytes .
15340654	0	CD4	42,45	CD8	26,29	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY +|nmod|T +|compound|END_ENTITY	Giant_cell_arteritis with CD8 + instead of CD4 + T lymphocytes as the predominant infiltrating cells in a young woman .
1535793	0	CD4	12,15	CD8	17,20	CD4	CD8	920	925	Gene	Gene	double-negative|compound|START_ENTITY double-negative|dep|END_ENTITY	Presence of CD4 , CD8 double-negative and T-cell receptor-gamma-delta-positive T cells in lymphocyte cultures propagated from coronary arteries from heart transplant patients with graft coronary disease .
15366657	6	CD4	1070,1073	CD8	1031,1034	CD4	CD8	920	925	Gene	Gene	PBMC|compound|START_ENTITY HIV-1|dobj|PBMC T|ccomp|HIV-1 T|nsubj|majority majority|nmod|+ +|dep|END_ENTITY	The majority of p24 + / CD4 - / CD8 - T lymphocytes were HIV-1 infected CD4 down-modulated PBMC .
15380534	0	CD4	88,91	CD8	0,3	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY numbers|nmod|cells reach|nmod|numbers reach|nsubj|cells cells|nummod|END_ENTITY	CD8 + T cells responding to influenza_infection reach and persist at higher numbers than CD4 + T cells independently of precursor frequency .
1544171	0	CD4	52,55	CD8	56,59	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Thymic nurse cells exclusively bind and internalize CD4 + CD8 + thymocytes .
15475958	0	CD4	8,11	CD8	54,57	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|dep|licensing licensing|nmod|cells cells|nmod|T T|compound|END_ENTITY	Cognate CD4 -LRB- + -RRB- T cell licensing of dendritic cells in CD8 -LRB- + -RRB- T cell immunity .
15600300	0	CD4	91,94	CD8	102,105	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY correlation|nmod|CD25 expression|dep|correlation expression|dep|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
15725752	0	CD4	120,123	CD8	111,114	CD4	CD8	920	925	Gene	Gene	responses|compound|START_ENTITY elicited|nmod|responses elicited|nmod|vaccine vaccine|appos|conservation conservation|nmod|END_ENTITY	Studies in macaques on cross-clade T cell responses elicited by a DNA/MVA AIDS vaccine , better conservation of CD8 than CD4 T cell responses .
15731226	0	CD4	42,45	CD8	18,21	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY response|nmod|CD25 Modulation|dep|response Modulation|nmod|+ +|compound|END_ENTITY	Modulation of the CD8 + - T-cell response by CD4 + CD25 + regulatory T cells in patients with hepatitis_B_virus infection .
15731353	0	CD4	4,7	CD8	20,23	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	molecule|compound|START_ENTITY molecule|nmod|lymphocytes lymphocytes|compound|END_ENTITY	The CD4 molecule on CD8 + T lymphocytes directly enhances the immune response to viral and cellular antigens .
1574118	0	CD4	30,33	CD8	101,104	CD4	CD8	920	925	Gene	Gene	interaction|nmod|START_ENTITY mediated|nsubj|interaction mediated|nmod|END_ENTITY	MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8 .
15744305	0	CD4	0,3	CD8	26,29	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY help|nsubj|T-cell help|dobj|memory memory|compound|END_ENTITY	CD4 + T-cell help controls CD8 + T-cell memory via TRAIL-mediated activation-induced cell death .
15816016	0	CD4	81,84	CD8	38,41	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY absence|nmod|help important|nmod|absence important|nmod|cytotoxicity cytotoxicity|compound|END_ENTITY	IL-4Ralpha signaling is important for CD8 + T cell cytotoxicity in the absence of CD4 + T cell help .
1586742	0	CD4	72,75	CD8	77,80	CD4	CD8	920	925	Gene	Gene	population|nmod|START_ENTITY proliferation|nmod|population END_ENTITY|nmod|proliferation	Evidence for in vivo clonal proliferation of unique population of blood CD4 - / CD8 - T cells bearing T-cell receptor alpha and beta chains in two normal men .
15884050	0	CD4	49,52	CD8	6,9	CD4	CD8	920	925	Gene	Gene	blasts|compound|START_ENTITY sensitive|nmod|blasts sensitive|nsubj|blasts blasts|compound|END_ENTITY	Human CD8 + T cell blasts are more sensitive than CD4 + T cell blasts to regulation by APO2L/TRAIL .
15944248	0	CD4	58,61	CD8	23,26	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY responses|nmod|cells effector|dobj|responses effector|nsubj|model model|nmod|T T|compound|END_ENTITY	A new dynamic model of CD8 + T effector cell responses via CD4 + T helper-antigen-presenting cells .
15968737	0	CD4	18,21	CD8	64,67	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY Depletion|nmod|cells enhances|nsubj|Depletion enhances|dobj|response response|compound|END_ENTITY	Depletion of CD25 + CD4 + T cells -LRB- Tregs -RRB- enhances the HBV-specific CD8 + T cell response primed by DNA immunization .
15972637	0	CD4	139,142	CD8	93,96	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY independent|nmod|help cells|ccomp|independent cells|compound|END_ENTITY	Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help .
16005184	0	CD4	10,13	CD8	43,46	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY Effect|nmod|CD25 +|nsubj|Effect +|nmod|function function|compound|END_ENTITY	Effect of CD4 + CD25 + regulatory T-cells on CD8 T-cell function in patients with autoimmune_hepatitis .
16006219	0	CD4	14,17	CD8	21,24	CD4	CD8	920	925	Gene	Gene	Evaluation|nmod|START_ENTITY status|dep|Evaluation status|compound|END_ENTITY	Evaluation of CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- status and urinary_tract_infections associated with urinary_schistosomiasis among some rural Nigerians .
16060130	0	CD4	64,67	CD8	69,72	CD4	CD8	920	925	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Effect of hormone replacement therapy on CD4 + and CD8 + numbers , CD4 + / CD8 + ratio , and immunoglobulin levels in hemodialysis patients .
16078259	0	CD4	29,32	CD8	24,27	CD4	CD8	920	925	Gene	Gene	CD68|appos|START_ENTITY CD68|compound|END_ENTITY	The predictive value of CD8 , CD4 , CD68 , and human leukocyte antigen-D-related cells in the prognosis of cutaneous_malignant_melanoma with vertical growth phase .
16210586	0	CD4	60,63	CD8	64,67	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Inefficient cell spreading and cytoskeletal polarization by CD4 + CD8 + thymocytes : regulation by the thymic environment .
16219490	0	CD4	95,98	CD8	85,88	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Transfection of dendritic cells with in vitro-transcribed CMV RNA induces polyclonal CD8 + - and CD4 + - mediated CMV-specific T cell responses .
16288380	0	CD4	0,3	CD8	153,156	CD4	CD8	920	925	Gene	Gene	recovery|compound|START_ENTITY influenced|nsubjpass|recovery influenced|nmod|activation activation|compound|END_ENTITY	CD4 + T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8 + T cell activation .
16398656	0	CD4	81,84	CD8	85,88	CD4	CD8	920	925	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	TLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4 + CD8 + double-positive stage .
16438648	0	CD4	26,29	CD8	32,35	CD4	CD8	920	925	Gene	Gene	persistence|nmod|START_ENTITY persistence|dep|END_ENTITY	HIV_type_1 persistence in CD4 - / CD8 - double_negative T cells from patients on antiretroviral therapy .
16443370	0	CD4	14,17	CD8	47,50	CD4	CD8	920	925	Gene	Gene	Treg|compound|START_ENTITY Treg|nmod|+ +|compound|END_ENTITY	The impact of CD4 + CD25 + Treg on tumor specific CD8 + T cell cytotoxicity and cancer .
16448546	0	CD4	43,46	CD8	47,50	CD4	CD8	920	925	Gene	Gene	Th-POK|nmod|START_ENTITY Role|nmod|Th-POK Role|dep|END_ENTITY	Role of the transcription factor Th-POK in CD4 : CD8 lineage commitment .
16455988	0	CD4	94,97	CD8	20,23	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY alloantigen|nmod|help generated|xcomp|alloantigen generated|nsubjpass|cells cells|nummod|END_ENTITY	Effector and memory CD8 + T cells can be generated in response to alloantigen independently of CD4 + T cell help .
16456009	0	CD4	17,20	CD8	54,57	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY ligation|nmod|cells enhances|nsubj|ligation enhances|dobj|responses responses|compound|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16506292	0	CD4	27,30	CD8	31,34	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intestinal double-positive CD4 + CD8 + T cells are highly activated memory cells with an increased capacity to produce cytokines .
16529787	0	CD4	0,3	CD8	120,123	CD4	CD8	920	925	Gene	Gene	primary|compound|START_ENTITY measles_virus|nsubj|primary measles_virus|parataxis|dependent dependent|nmod|activity activity|nmod|cells cells|compound|END_ENTITY	CD4 T cell control primary measles_virus infection of the CNS : regulation is dependent on combined activity with either CD8 T cells or with B cells : CD4 , CD8 or B cells alone are ineffective .
16529787	0	CD4	149,152	CD8	120,123	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY ineffective|nsubj|cells measles_virus|parataxis|ineffective measles_virus|parataxis|dependent dependent|nmod|activity activity|nmod|cells cells|compound|END_ENTITY	CD4 T cell control primary measles_virus infection of the CNS : regulation is dependent on combined activity with either CD8 T cells or with B cells : CD4 , CD8 or B cells alone are ineffective .
16551878	0	CD4	194,197	CD8	24,27	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY epitope|nsubj|T-cell epitope|advcl|vitro vitro|dobj|stimulation stimulation|nmod|cells cells|compound|END_ENTITY	In vitro stimulation of CD8 and CD4 T cells by dendritic cells loaded with a complex of cholesterol-bearing hydrophobized pullulan and NY-ESO-1 protein : Identification of a new HLA-DR15-binding CD4 T-cell epitope .
16585963	0	CD4	29,32	CD8	82,85	CD4	CD8	920	925	Gene	Gene	lymphocytes|nummod|START_ENTITY untransformed|dobj|lymphocytes untransformed|advcl|protecting protecting|dobj|cells cells|nummod|END_ENTITY	HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death .
16604076	0	CD4	96,99	CD8	41,44	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY requires|dobj|cells requires|nsubj|generation generation|nmod|cells cells|compound|END_ENTITY	The generation of protective memory-like CD8 + T cells during homeostatic proliferation requires CD4 + T cells .
16612374	0	CD4	70,73	CD8	45,48	CD4	CD8	920	925	Gene	Gene	interaction|compound|START_ENTITY sites|nmod|interaction cells|nmod|sites cells|compound|END_ENTITY	Chemokines enhance immunity by guiding naive CD8 + T cells to sites of CD4 + T cell-dendritic cell interaction .
16673447	0	CD4	0,3	CD8	40,43	CD4	CD8	920	925	Gene	Gene	help|nummod|START_ENTITY required|nsubjpass|help required|nmod|responses responses|compound|END_ENTITY	CD4 T cell help is required for primary CD8 T cell responses to vesicular antigen delivered to dendritic cells in vivo .
16699374	0	CD4	99,102	CD8	52,55	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY decrease|nmod|cells expansion|nmod|decrease expansion|nmod|+ +|compound|END_ENTITY	IL-7 administration to humans leads to expansion of CD8 + and CD4 + cells but a relative decrease of CD4 + T-regulatory cells .
1672332	0	CD4	94,97	CD8	18,21	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY absence|nmod|cells collaborate|nmod|absence +|ccomp|collaborate +|nsubj|Subpopulations Subpopulations|nmod|END_ENTITY	Subpopulations of CD8 + cytotoxic T cell precursors collaborate in the absence of conventional CD4 + helper T cells .
1673445	0	CD4	94,97	CD8	0,3	CD4	CD8	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY inhibit|nmod|lymphocytes inhibit|nsubj|cells cells|compound|END_ENTITY	CD8 + suppressor cells inhibit staphylococcal_protein_A-induced gamma interferon production by CD4 + lymphocytes .
16767155	0	CD4	60,63	CD8	65,68	CD4	CD8	920	925	Gene	Gene	thymic_lymphoma|compound|START_ENTITY thymic_lymphoma|compound|END_ENTITY	CD95 ligand mediates T-cell_receptor-induced apoptosis of a CD4 + CD8 + double positive thymic_lymphoma .
16769750	0	CD4	0,3	CD8	24,27	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY inhibit|nsubj|cells inhibit|dobj|response response|compound|END_ENTITY	CD4 T cells inhibit the CD8 T cell response during low-dose virus_infection .
16799989	0	CD4	58,61	CD8	106,109	CD4	CD8	920	925	Gene	Gene	function|compound|START_ENTITY function|nmod|responses responses|compound|END_ENTITY	Outcome of acute hepatitis_C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses .
1682152	0	CD4	0,3	CD8	4,7	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD8 + CD3high thymocytes appear transiently during ontogeny : evidence from phenotypic and functional studies .
16824651	0	CD4	39,42	CD8	15,18	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|nummod|END_ENTITY	Maintenance of CD8 effector T cells by CD4 helper T cells eradicates growing tumors and promotes long-term tumor immunity .
16828790	0	CD4	101,104	CD8	31,34	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY +|nmod|cells +|nsubj|Generation Generation|nmod|END_ENTITY	Generation of peptide-specific CD8 + T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4 + T cells .
1683650	0	CD4	65,68	CD8	70,73	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Immunostimulatory activity of lactotransferrin and maturation of CD4 - CD8 - murine thymocytes .
16839913	0	CD4	31,34	CD8	36,39	CD4	CD8	920	925	Gene	Gene	ration|compound|START_ENTITY ration|compound|END_ENTITY	Alterations in serum cortisol , CD4 + CD8 + lymphocyte sub-population ration and T cell mediated suppression of immune responses in the malnutrition of anorexia_nervosa .
16849444	0	CD4	22,25	CD8	72,75	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY promotes|nsubj|help promotes|dobj|recruitment recruitment|nmod|cells cells|compound|END_ENTITY	Cutting edge : cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells .
1690353	0	CD4	57,60	CD8	61,64	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
1690353	0	CD4	91,94	CD8	61,64	CD4	CD8	920	925	Gene	Gene	influenced|nmod|START_ENTITY thymocytes|dep|influenced thymocytes|nsubj|regulation regulation|nmod|expression expression|nmod|+ +|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
16914556	0	CD4	67,70	CD8	71,74	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Modulation of pro- and antiapoptotic molecules in double-positive -LRB- CD4 + CD8 + -RRB- thymocytes following dexamethasone treatment .
16925953	0	CD4	51,54	CD8	57,60	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY lymphocyte|appos|+ differences|nmod|lymphocyte _|nmod|differences _|dobj|+ +|compound|END_ENTITY	Within and between race differences in lymphocyte , CD4 + , _ CD8 + and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda .
16977797	0	CD4	38,41	CD8	22,25	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY antigens|nmod|cells antigens|nsubj|expression expression|nmod|END_ENTITY	A false expression of CD8 antigens on CD4 + T cells in a routine flow cytometry analysis .
16980510	0	CD4	0,3	CD8	32,35	CD4	CD8	920	925	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|stimulate stimulate|ccomp|T T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cells stimulate memory CD8 -LRB- + -RRB- T cell expansion via acquired pMHC I complexes and costimulatory molecules , and IL-2 secretion .
17030653	0	CD4	8,11	CD8	13,16	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	Altered CD4 + / CD8 + T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple_sclerosis .
17047079	0	CD4	41,44	CD8	15,18	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY function|nmod|CD25 function|nsubj|Attenuation Attenuation|nmod|T-cell T-cell|compound|END_ENTITY	Attenuation of CD8 -LRB- + -RRB- T-cell function by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in B-cell_non-Hodgkin 's _ lymphoma .
17050078	0	CD4	18,21	CD8	22,25	CD4	CD8	920	925	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	A double-positive CD4 + CD8 + T-cell population is commonly found in nodular lymphocyte predominant Hodgkin_lymphoma .
1706390	1	CD4	84,87	CD8	155,158	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY interaction|nmod|cells Requirement|nmod|interaction Requirement|nmod|cells cells|compound|END_ENTITY	Requirement for interaction with infected CD4 + cells and induction of infectious virus from chronically infected CD8 + cells .
1707762	0	CD4	113,116	CD8	73,76	CD4	CD8	920	925	Gene	Gene	subset|compound|START_ENTITY stimulation|nmod|subset cells|dep|stimulation cells|nummod|+ +|compound|END_ENTITY	Differential responses of CD4 + CD45RA + and CD4 + CD29 + subsets to activated CD8 + cells : enhanced stimulation of the CD4 + CD45RA + subset by cells from patients with multiple_sclerosis .
1707762	0	CD4	26,29	CD8	73,76	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY responses|nmod|+ subsets|nsubj|responses subsets|xcomp|activated activated|dobj|cells cells|nummod|+ +|compound|END_ENTITY	Differential responses of CD4 + CD45RA + and CD4 + CD29 + subsets to activated CD8 + cells : enhanced stimulation of the CD4 + CD45RA + subset by cells from patients with multiple_sclerosis .
17082578	0	CD4	9,12	CD8	13,16	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immature CD4 + CD8 + thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation .
17085920	0	CD4	28,31	CD8	13,16	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY T|appos|+ T|appos|T T|compound|END_ENTITY	Decreases in CD8 + T , naive -LRB- CD4 + CD45RA + -RRB- T , and B -LRB- CD19 + -RRB- lymphocytes by exposure to manganese fume .
17090688	0	CD4	102,105	CD8	106,109	CD4	CD8	920	925	Gene	Gene	line|compound|START_ENTITY line|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
17090688	0	CD4	61,64	CD8	106,109	CD4	CD8	920	925	Gene	Gene	differentiation|compound|START_ENTITY differentiation|nmod|line line|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
17123986	0	CD4	0,3	CD8	25,28	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY counts|nsubj|T-cell counts|dep|count count|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + T-cell counts , CD4 + / CD8 + T-cell count ratios , and antibody levels in migrant fishermen infected with Schistosoma_japonicum in the Dongting Lake , China .
17123986	0	CD4	20,23	CD8	25,28	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	CD4 + T-cell counts , CD4 + / CD8 + T-cell count ratios , and antibody levels in migrant fishermen infected with Schistosoma_japonicum in the Dongting Lake , China .
17163450	0	CD4	45,48	CD8	0,3	CD4	CD8	920	925	Gene	Gene	responses|compound|START_ENTITY regulation|nmod|responses +|dobj|regulation +|nsubj|END_ENTITY	CD8 + suppressor-mediated regulation of human CD4 + T cell responses to glutamic_acid decarboxylase 65 .
1719558	0	CD4	47,50	CD8	51,54	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ligand-stimulated signaling events in immature CD4 + CD8 + thymocytes expressing competent T-cell receptor complexes .
1721862	0	CD4	6,9	CD8	11,14	CD4	CD8	920	925	Gene	Gene	CD7|nummod|START_ENTITY CD7|dep|END_ENTITY	CD7 + , CD4 - / CD8 - acute_leukemia with t -LRB- 11 ; 14 -RRB- -LRB- p15 ; q11 -RRB- in a child .
17249210	0	CD4	54,57	CD8	61,64	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Study of the significance of percentage of peripheral CD4 + _ CD8 + T cells and the hepatitis_C virus genotypes in Egyptian patients with chronic hepatitis_C .
17258077	0	CD4	39,42	CD8	45,48	CD4	CD8	920	925	Gene	Gene	generation|nmod|START_ENTITY IL-2-independent|dobj|generation IL-2-independent|dep|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17277112	0	CD4	21,24	CD8	83,86	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY facilitate|nsubj|cells facilitate|xcomp|priming priming|nmod|cells cells|compound|END_ENTITY	Type I IFN-producing CD4 Valpha14i NKT cells facilitate priming of IL-10-producing CD8 T cells by hepatocytes .
17277113	0	CD4	8,11	CD8	111,114	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY help|nsubj|+ help|ccomp|impair impair|nmod|cells cells|compound|END_ENTITY	Cognate CD4 + help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8 + T cells .
17313653	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD8 + T cells in young and elderly humans .
17339421	0	CD4	78,81	CD8	47,50	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY absence|nmod|help ligand|nmod|absence ligand|dobj|cells cells|compound|END_ENTITY	TLR3 ligand stimulates fully functional memory CD8 + T cells in the absence of CD4 + T-cell help .
17375073	0	CD4	15,18	CD8	35,38	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY role|nmod|T elicited|nmod|role elicited|nsubj|cells cells|nmod|response response|compound|END_ENTITY	On the role of CD4 + T cells in the CD8 + T-cell response elicited by recombinant adenovirus vaccines .
17438031	0	CD4	7,10	CD8	35,38	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY enhance|nsubj|cells enhance|dobj|responses responses|compound|END_ENTITY	Memory CD4 T cells enhance primary CD8 T-cell responses .
17442927	0	CD4	6,9	CD8	87,90	CD4	CD8	920	925	Gene	Gene	+|nsubj|START_ENTITY +|dep|displaying displaying|ccomp|elicit elicit|dobj|memory memory|dep|response response|compound|END_ENTITY	Human CD4 + T cells displaying viral epitopes elicit a functional virus-specific memory CD8 + T cell response .
17475864	0	CD4	16,19	CD8	57,60	CD4	CD8	920	925	Gene	Gene	cell|compound|START_ENTITY Requirement|nmod|cell help|nsubj|Requirement help|ccomp|dependent dependent|nsubj|responses responses|compound|END_ENTITY	Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent .
1750726	0	CD4	36,39	CD8	41,44	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY induction|nmod|+ induction|dep|cells cells|nummod|END_ENTITY	Interleukin_4-mediated induction of CD4 + / CD8 + T cells during infancy .
17513729	0	CD4	24,27	CD8	111,114	CD4	CD8	920	925	Gene	Gene	responses|compound|START_ENTITY target|nsubj|responses target|xcomp|distinct distinct|nmod|those those|acl|targeted targeted|nmod|responses responses|compound|END_ENTITY	Vaccinia_virus-specific CD4 + T cell responses target a set of antigens largely distinct from those targeted by CD8 + T cell responses .
17898053	0	CD4	133,136	CD8	13,16	CD4	CD8	920	925	Gene	Gene	activation|compound|START_ENTITY macaques|nmod|activation macaques|nsubj|T-cell T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
17917058	0	CD4	31,34	CD8	0,3	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|dep|T T|compound|END_ENTITY	CD8 T cell memory development : CD4 T cell help is appreciated .
17947656	0	CD4	15,18	CD8	137,140	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY generated|nsubj|cells generated|nmod|cell cell|acl|priming priming|ccomp|influence influence|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	Cognate memory CD4 + T cells generated with dendritic cell priming influence the expansion , trafficking , and differentiation of secondary CD8 + T cells and enhance tumor control .
17967458	0	CD4	53,56	CD8	83,86	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY response|nmod|cells impairs|nsubj|response impairs|dobj|response response|compound|END_ENTITY	Defective T helper response of hepatocyte-stimulated CD4 T cells impairs antiviral CD8 response and viral clearance .
17981791	0	CD4	39,42	CD8	43,46	CD4	CD8	920	925	Gene	Gene	differentiation|compound|START_ENTITY differentiation|compound|END_ENTITY	Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex , by mimicking pre-TCR signals .
17997138	0	CD4	57,60	CD8	82,85	CD4	CD8	920	925	Gene	Gene	counts|nsubj|START_ENTITY counts|dobj|activation activation|compound|END_ENTITY	Intensification of a suppressive HAART regimen increases CD4 counts and decreases CD8 + T-cell activation .
18021092	0	CD4	41,44	CD8	45,48	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Age-dependent accumulation of monoclonal CD4 + CD8 + double positive T lymphocytes in the peripheral blood of the elderly .
18056368	0	CD4	0,3	CD8	29,32	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY required|nsubjpass|cells required|nmod|survival survival|compound|END_ENTITY	CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses .
18090392	0	CD4	19,22	CD8	15,18	CD4	CD8	920	925	Gene	Gene	decay|compound|START_ENTITY +|dobj|decay +|nsubj|END_ENTITY	HIV-1-infected CD8 + CD4 + T cells decay in vivo at a similar rate to infected CD4 T cells during HAART .
18090392	0	CD4	76,79	CD8	15,18	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY rate|nmod|cells +|nmod|rate +|nsubj|END_ENTITY	HIV-1-infected CD8 + CD4 + T cells decay in vivo at a similar rate to infected CD4 T cells during HAART .
18184713	0	CD4	13,16	CD8	25,28	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|nmod|responses responses|nummod|END_ENTITY	Differential CD4 + versus CD8 + T-cell responses elicited by different poxvirus-based human_immunodeficiency_virus_type_1 vaccine candidates provide comparable efficacies in primates .
18246596	0	CD4	29,32	CD8	87,90	CD4	CD8	920	925	Gene	Gene	CCL5|compound|START_ENTITY CCL5|nmod|growth growth|nmod|elimination elimination|compound|END_ENTITY	Gastric_cancer cells exploit CD4 + cell-derived CCL5 for their growth and prevention of CD8 + cell-involved tumor elimination .
1825509	0	CD4	13,16	CD8	18,21	CD4	CD8	920	925	Gene	Gene	patient|nmod|START_ENTITY patient|dep|T-cell_leukemia T-cell_leukemia|compound|END_ENTITY	A patient of CD4 - / CD8 + chronic T-cell_leukemia associated with hypercalcemia .
18257774	0	CD4	59,62	CD8	19,22	CD4	CD8	920	925	Gene	Gene	recovery|compound|START_ENTITY association|nmod|recovery has|dobj|association has|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy .
1825806	0	CD4	52,55	CD8	6,9	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ absence|nmod|cells stimulated|nmod|absence lymphocytes|dep|stimulated lymphocytes|nsubj|+ +|compound|END_ENTITY	Human CD8 + lymphocytes stimulated in the absence of CD4 + cells enhance IgG production by antibody-secreting B cells .
1827129	0	CD4	19,22	CD8	24,27	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY analysis|nmod|+ analysis|dep|cells cells|nummod|END_ENTITY	Clonal analysis of CD4 + / CD8 + T cells in a patient with aplastic_anemia .
18273057	0	CD4	40,43	CD8	78,81	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY secreted|nmod|cells secreted|advcl|enhancing enhancing|dobj|responses responses|compound|END_ENTITY	Role of IL-2 secreted by PADRE-specific CD4 + T cells in enhancing E7-specific CD8 + T-cell immune responses .
1828937	0	CD4	40,43	CD8	5,8	CD4	CD8	920	925	Gene	Gene	mycosis_fungoides|compound|START_ENTITY skin_lesions|nmod|mycosis_fungoides cells|nmod|skin_lesions cells|nsubj|cells cells|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18292535	0	CD4	15,18	CD8	100,103	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY render|nsubj|cells render|nmod|cells cells|compound|END_ENTITY	Tumor-specific CD4 + T cells render the tumor environment permissive for infiltration by low-avidity CD8 + T cells .
1829396	0	CD4	62,65	CD8	67,70	CD4	CD8	920	925	Gene	Gene	proliferation|nmod|START_ENTITY Regulation|nmod|proliferation Regulation|dep|END_ENTITY	Regulation of thymocyte proliferation by alpha beta TcR + CD3 + CD4 - CD8 - cloned natural suppressor -LRB- NS -RRB- cells .
18362335	0	CD4	23,26	CD8	37,40	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY mediator|nmod|+ IL-15|nmod|mediator help|nsubj|IL-15 help|nmod|longevity longevity|compound|END_ENTITY	IL-15 as a mediator of CD4 + help for CD8 + T cell longevity and avoidance of TRAIL-mediated apoptosis .
18367534	0	CD4	32,35	CD8	48,51	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|rhesus_monkeys rhesus_monkeys|nummod|END_ENTITY	Increased loss of CCR5 + CD45RA - CD4 + T cells in CD8 + lymphocyte-depleted Simian_immunodeficiency_virus-infected rhesus_monkeys .
1846951	0	CD4	13,16	CD8	64,67	CD4	CD8	920	925	Gene	Gene	START_ENTITY|nmod|HIV-1_infection HIV-1_infection|nmod|T T|compound|END_ENTITY	Induction of CD4 and susceptibility to HIV-1_infection in human CD8 + T lymphocytes by human_herpesvirus_6 .
18490719	0	CD4	49,52	CD8	82,85	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY frequency|nmod|help required|nsubjpass|frequency required|nmod|rejection rejection|compound|END_ENTITY	A critical precursor frequency of donor-reactive CD4 + T cell help is required for CD8 + T cell-mediated CD28/CD154-independent rejection .
18504453	0	CD4	27,30	CD8	31,34	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	The FOXP3 + subset of human CD4 + CD8 + thymocytes is immature and subject to intrathymic selection .
18506879	0	CD4	0,3	CD8	26,29	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY improves|nsubj|help improves|dobj|memory memory|compound|END_ENTITY	CD4 + T cell help improves CD8 + T cell memory by retained CD27 expression .
18506880	0	CD4	66,69	CD8	22,25	CD4	CD8	920	925	Gene	Gene	deficiency|compound|START_ENTITY response|nmod|deficiency response|compound|END_ENTITY	Generating functional CD8 + T cell memory response under transient CD4 + T cell deficiency : implications for vaccination of immunocompromised individuals .
18515560	0	CD4	104,107	CD8	109,112	CD4	CD8	920	925	Gene	Gene	leukaemia|compound|START_ENTITY leukaemia|compound|END_ENTITY	Severe and recurrent episodes of bronchiolitis_obliterans_organising_pneumonia associated with indolent CD4 + CD8 + T-cell leukaemia .
18534691	0	CD4	102,105	CD8	107,110	CD4	CD8	920	925	Gene	Gene	START_ENTITY|appos|expression expression|nummod|END_ENTITY	Human umbilical cord blood-derived non-hematopoietic stem cells suppress lymphocyte proliferation and CD4 , CD8 expression .
18566395	0	CD4	0,3	CD8	59,62	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY regulates|nsubj|help regulates|dobj|expression expression|nmod|genes genes|acl|involved involved|nmod|memory memory|compound|END_ENTITY	CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements .
18602973	0	CD4	152,155	CD8	156,159	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
18602973	0	CD4	166,169	CD8	156,159	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY controlling|nmod|thymocytes controlling|dobj|commitment commitment|nmod|+ +|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
18606659	0	CD4	15,18	CD8	59,62	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY instructs|dobj|cells instructs|xcomp|provide provide|nmod|response response|nummod|END_ENTITY	CD27 instructs CD4 + T cells to provide help for the memory CD8 + T cell response after protein immunization .
18649854	0	CD4	137,140	CD8	143,146	CD4	CD8	920	925	Gene	Gene	appearance|nmod|START_ENTITY factors|nmod|appearance factors|appos|END_ENTITY	Decreased maturation of T-cell populations in the healthy elderly : Influence of nutritional factors on the appearance of double negative CD4 - , CD8 - , CD2 + cells .
18676551	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|ratio ratio|compound|END_ENTITY	CD4 + / CD8 + T cell ratio for diagnosis of HIV-1_infection in infants : Women and Infants Transmission Study .
18768393	0	CD4	44,47	CD8	54,57	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|NKa NKa|dep|+ +|dep|END_ENTITY	Expanded cells in monoclonal TCR-alphabeta + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis recognize hCMV antigens .
18784457	0	CD4	44,47	CD8	5,8	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY correlate|nmod|cells correlate|nsubj|T-cells T-cells|compound|END_ENTITY	CD38 + CD8 + T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals .
18818318	0	CD4	118,121	CD8	63,66	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY compromised|nmod|cells compromised|nsubjpass|clearance clearance|nmod|cells cells|amod|murine_gammaherpesvirus_68 murine_gammaherpesvirus_68|nmod|END_ENTITY	Primary clearance of murine_gammaherpesvirus_68 by PKCtheta - / - CD8 T cells is compromised in the absence of help from CD4 T cells .
18836718	0	CD4	57,60	CD8	62,65	CD4	CD8	920	925	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|END_ENTITY	Characterization of MHC class-I restricted TCRalphabeta + CD4 - CD8 - double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination .
18941186	0	CD4	15,18	CD8	34,37	CD4	CD8	920	925	Gene	Gene	help|nsubj|START_ENTITY help|xcomp|rescue rescue|dobj|killers killers|compound|END_ENTITY	Heterospecific CD4 help to rescue CD8 T cell killers .
19047170	0	CD4	107,110	CD8	72,75	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY occur|nmod|cells occur|nsubj|expansion expansion|nmod|cells cells|compound|END_ENTITY	In vivo expansion , persistence , and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells .
19072838	0	CD4	91,94	CD8	21,24	CD4	CD8	920	925	Gene	Gene	count|compound|START_ENTITY CD38|nmod|count association|dep|CD38 association|nmod|+ +|compound|END_ENTITY	Close association of CD8 + / CD38 bright with HIV-1 replication and complex relationship with CD4 + T-cell count .
1911543	0	CD4	48,51	CD8	24,27	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY expressed|nmod|T expressed|nsubj|analysis analysis|nmod|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
1911543	0	CD4	48,51	CD8	53,56	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
19120311	0	CD4	47,50	CD8	21,24	CD4	CD8	920	925	Gene	Gene	responses|compound|START_ENTITY regulating|dobj|responses T|advcl|regulating T|nsubj|role role|nmod|END_ENTITY	The sentinel role of CD8 T cells in regulating CD4 T cell responses to proinsulin in beta-islet cell autoimmunity .
19133978	0	CD4	0,3	CD8	74,77	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY FoxP3|nsubj|CD25 increased|dep|FoxP3 increased|nsubjpass|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19133978	0	CD4	68,71	CD8	74,77	CD4	CD8	920	925	Gene	Gene	increased|dobj|START_ENTITY increased|nsubjpass|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19139082	0	CD4	8,11	CD8	68,71	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY essential|nsubj|help essential|nmod|reactivation reactivation|nmod|cells cells|nummod|END_ENTITY	Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen , H60 .
19155494	0	CD4	18,21	CD8	72,75	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY circulating|dobj|+ Human|acl|circulating autologous|nsubj|Human autologous|dobj|+ +|compound|END_ENTITY	Human circulating CD4 + CD25highFoxp3 + regulatory T cells kill autologous CD8 + but not CD4 + responder cells by Fas-mediated apoptosis .
19176318	0	CD4	34,37	CD8	39,42	CD4	CD8	920	925	Gene	Gene	TCR_alpha|compound|START_ENTITY TCR_alpha|dep|END_ENTITY	FAS-L , IL-10 , and double-negative CD4 - CD8 - TCR_alpha / beta + T cells are reliable markers of autoimmune_lymphoproliferative_syndrome -LRB- ALPS -RRB- associated with FAS loss of function .
1920621	0	CD4	75,78	CD8	89,92	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Inhibition of human immunodeficiency virus replication in acutely infected CD4 + cells by CD8 + cells involves a noncytotoxic mechanism .
19279095	0	CD4	0,3	CD8	45,48	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY required|nsubjpass|cells required|nmod|priming priming|nmod|cells cells|nummod|END_ENTITY	CD4 + T cells are required for the priming of CD8 + T cells following infection with herpes_simplex_virus_type_1 .
19328310	0	CD4	62,65	CD8	67,70	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	-LSB- Two cases of subcutaneous panniculitis-like T-cell_lymphoma -LRB- CD4 - CD8 + CD56 - -RRB- -RSB- .
19410556	0	CD4	12,15	CD8	32,35	CD4	CD8	920	925	Gene	Gene	cell|compound|START_ENTITY role|nmod|cell help|nsubj|role help|nmod|activation activation|compound|END_ENTITY	The role of CD4 T cell help for CD8 CTL activation .
19429259	0	CD4	77,80	CD8	81,84	CD4	CD8	920	925	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Induction of S100A4 , S100A6 , and galectin-1 during the lineage commitment of CD4 + CD8 + thymocyte cell line is suppressed by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
19458000	0	CD4	150,153	CD8	45,48	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY point|nmod|cells determinants|nmod|point determinants|nsubj|responses responses|compound|END_ENTITY	Human_immunodeficiency_virus_type_1-specific CD8 + T-cell responses during primary_infection are major determinants of the viral set point and loss of CD4 + T cells .
19535638	0	CD4	49,52	CD8	90,93	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|suppress suppress|dobj|generation generation|nmod|responses responses|nummod|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19546246	0	CD4	9,12	CD8	51,54	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|induced induced|nmod|depletion depletion|compound|END_ENTITY	Profound CD4 + / CCR5 + T cell expansion is induced by CD8 + lymphocyte depletion but does not account for accelerated SIV pathogenesis .
19616200	0	CD4	11,14	CD8	15,18	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19620303	0	CD4	45,48	CD8	49,52	CD4	CD8	920	925	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Rare development of Foxp3 + thymocytes in the CD4 + CD8 + subset .
19692644	0	CD4	0,3	CD8	52,55	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY has|nsubj|help has|dobj|impact impact|nmod|inflation inflation|compound|END_ENTITY	CD4 + T cell help has an epitope-dependent impact on CD8 + T cell memory inflation during murine_cytomegalovirus_infection .
19700667	0	CD4	95,98	CD8	65,68	CD4	CD8	920	925	Gene	Gene	coexpresses|dobj|START_ENTITY cells|ccomp|coexpresses cells|compound|END_ENTITY	Potent HIV-specific responses are enriched in a unique subset of CD8 + T cells that coexpresses CD4 on its surface .
1970668	0	CD4	0,3	CD8	21,24	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	CD4 + , CD8 + , and CD4 - CD8 - T cells in CSF and blood of patients with multiple_sclerosis and tension_headache .
1970729	0	CD4	22,25	CD8	27,30	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|CD4 CD4|dep|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD4	22,25	CD8	35,38	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|CD4 CD4|dep|CD8 CD8|nmod|+ +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD4	40,43	CD8	35,38	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|CD8 CD8|nmod|+ +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1972661	0	CD4	55,58	CD8	0,3	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY suppress|nmod|cells lymphocytes|xcomp|suppress lymphocytes|nsubj|+ +|compound|END_ENTITY	CD8 + lymphocytes suppress HIV production by autologous CD4 + cells without eliminating the infected cells from culture .
19734235	0	CD4	22,25	CD8	56,59	CD4	CD8	920	925	Gene	Gene	START_ENTITY|parataxis|derive derive|nmod|cells cells|compound|END_ENTITY	Human TCR-alpha beta + CD4 - CD8 - T cells can derive from CD8 + T cells and display an inflammatory effector phenotype .
1976704	0	CD4	50,53	CD8	54,57	CD4	CD8	920	925	Gene	Gene	differentiation|nmod|START_ENTITY +|nmod|differentiation +|nsubj|END_ENTITY	In vitro differentiation from a pluripotent human CD4 + CD8 + thymic cloned cell into four phenotypically distinct subsets .
1977770	0	CD4	29,32	CD8	34,37	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|T T|nsubj|+ +|compound|END_ENTITY	Elevated cerebrospinal fluid CD4 + / CD8 + T cell ratio in myasthenia_gravis .
19786539	0	CD4	59,62	CD8	0,3	CD4	CD8	920	925	Gene	Gene	proliferation|compound|START_ENTITY induces|dobj|proliferation induces|nsubj|depletion depletion|compound|END_ENTITY	CD8 + cell depletion of SHIV89.6P-infected macaques induces CD4 + T cell proliferation that contributes to increased viral loads .
1981372	0	CD4	0,3	CD8	130,133	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY secrete|nsubj|cells secrete|parataxis|suppress suppress|nsubj|cells cells|compound|END_ENTITY	CD4 cells from patients with autoimmune_thyroid_disease secrete interferon_gamma after stimulation by thyroid_microsomal_antigen ; CD8 cells suppress this secretion .
19887050	0	CD4	45,48	CD8	18,21	CD4	CD8	920	925	Gene	Gene	NKT|compound|START_ENTITY cells|nmod|NKT NKT|dobj|cells NKT|nsubj|END_ENTITY	EBV-induced human CD8 -LRB- + -RRB- NKT cells synergise CD4 -LRB- + -RRB- NKT cells suppressing EBV-associated tumours upon induction of Th1-bias .
19898495	0	CD4	67,70	CD8	0,3	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY requires|dobj|T-cell T|ccomp|requires T|nsubj|END_ENTITY	CD8 -LRB- + -RRB- T lymphocyte mobilization to virus-infected tissue requires CD4 -LRB- + -RRB- T-cell help .
19901991	0	CD4	0,3	CD8	71,74	CD4	CD8	920	925	Gene	Gene	IL-2|compound|START_ENTITY signals|nsubj|IL-2 signals|nmod|advances advances|dep|responses responses|compound|END_ENTITY	CD4 + T cell-derived IL-2 signals during early priming advances primary CD8 + T cell responses .
19917777	0	CD4	47,50	CD8	93,96	CD4	CD8	920	925	Gene	Gene	repression|nummod|START_ENTITY important|nmod|repression important|nmod|differentiation differentiation|compound|END_ENTITY	The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus .
19922421	0	CD4	63,66	CD8	114,117	CD4	CD8	920	925	Gene	Gene	induce|dobj|START_ENTITY activated|ccomp|induce cells|acl|activated T|nsubj|cells T|advcl|impairing impairing|dobj|memory memory|amod|END_ENTITY	Dendritic cells activated by an anti-inflammatory agent induce CD4 -LRB- + -RRB- T helper type 2 responses without impairing CD8 -LRB- + -RRB- memory and effector cytotoxic T-lymphocyte responses .
19949087	0	CD4	6,9	CD8	42,45	CD4	CD8	920	925	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|prevents prevents|ccomp|T T|nsubj|END_ENTITY	Early CD4 -LRB- + -RRB- T cell help prevents partial CD8 -LRB- + -RRB- T cell exhaustion and promotes maintenance of Herpes_Simplex_Virus_1 latency .
19966302	0	CD4	0,3	CD8	87,90	CD4	CD8	920	925	Gene	Gene	regulation|compound|START_ENTITY controls|nsubj|regulation controls|dobj|development development|nmod|cells cells|compound|END_ENTITY	CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses .
20045101	0	CD4	28,31	CD8	32,35	CD4	CD8	920	925	Gene	Gene	loci|nmod|START_ENTITY loci|parataxis|associated associated|nsubjpass|ratio ratio|nummod|END_ENTITY	Quantitative trait loci for CD4 : CD8 lymphocyte ratio are associated with risk of type_1_diabetes_and_HIV-1 immune control .
20108768	0	CD4	28,31	CD8	34,37	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY distribution|nmod|+ Frequency|appos|distribution END_ENTITY|nsubj|Frequency	-LSB- Frequency , distribution of CD4 + , CD8 + T cells and expression of CD38 in gastric mucosa of HIV_infections -RSB- .
20142839	0	CD4	56,59	CD8	61,64	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	Foxp3 induction in human and murine thymus precedes the CD4 + CD8 + stage but requires early T-cell receptor expression .
20147961	0	CD4	17,20	CD8	34,37	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY assist|nsubj|cells assist|dobj|cells cells|nummod|END_ENTITY	Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes .
20156102	0	CD4	0,3	CD8	41,44	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY T|nsubj|CD25 T|ccomp|inhibit inhibit|dep|utilizing utilizing|nsubj|production production|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells inhibit CD8 -LRB- + -RRB- IFN-gamma production during acute and chronic FIV_infection utilizing a membrane TGF-beta-dependent mechanism .
20157599	0	CD4	35,38	CD8	46,49	CD4	CD8	920	925	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Expression and Function of TLR2 on CD4 Versus CD8 T Cells .
20362206	0	CD4	53,56	CD8	113,116	CD4	CD8	920	925	Gene	Gene	epitopes|compound|START_ENTITY help|nsubj|epitopes help|nmod|development development|nmod|cells cells|compound|END_ENTITY	Hepatitis_B_virus _ -LRB- HBV -RRB- - derived DRB1 * 0101-restricted CD4 T-cell epitopes help in the development of HBV-specific CD8 + T cells in vivo .
20368790	0	CD4	6,9	CD8	21,24	CD4	CD8	920	925	Gene	Gene	capture|compound|START_ENTITY capture|nmod|cells cells|compound|END_ENTITY	Could CD4 capture by CD8 + T cells play a role in HIV spreading ?
20615979	0	CD4	80,83	CD8	85,88	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4 + CD8 + thymocytes .
20631314	0	CD4	32,35	CD8	57,60	CD4	CD8	920	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Beta-catenin signaling mediates CD4 expression on mature CD8 + T cells .
20639494	0	CD4	7,10	CD8	80,83	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY limit|nsubj|cells limit|advcl|modulating modulating|dobj|response response|compound|END_ENTITY	Foxp3 + CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory_syncytial_virus_infection .
20665390	2	CD4	380,383	CD8	384,387	CD4	CD8	920	925	Gene	Gene	values|nmod|START_ENTITY values|dep|ratio ratio|nummod|END_ENTITY	Several independent groups found almost identical predictive values of the CD4 : CD8 ratio in BAL for the diagnosis of sarcoidosis .
20686045	0	CD4	28,31	CD8	86,89	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY reduce|nsubj|cells reduce|advcl|preserving preserving|dobj|function function|compound|END_ENTITY	Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection .
20734711	0	CD4	9,12	CD8	14,17	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|associated associated|nsubj|ratio ratio|compound|END_ENTITY	Inverted CD4 + / CD8 + ratio associated with AIDS event and death_in_HIV-1_infected individuals in Nasarawa State , Nigeria .
20739776	0	CD4	0,3	CD8	14,17	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|nummod|+ T-cell_large_granular_lymphocytic_leukemia|compound|END_ENTITY	CD4 + / NKa _ + / CD8 -LRB- dim + -RRB- T-cell_large_granular_lymphocytic_leukemia : a rare entity .
20940398	0	CD4	0,3	CD8	91,94	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY help|nsubj|T-cell help|advcl|required required|nmod|function function|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD4 + T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8 + T lymphocytes .
21033101	0	CD4	28,31	CD8	34,37	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
21047960	0	CD4	31,34	CD8	128,131	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	responses|compound|START_ENTITY contribute|nsubj|responses contribute|nmod|modulation modulation|nmod|function function|compound|END_ENTITY	HIV-1-specific interleukin-21 + CD4 + T cell responses contribute to durable viral control through the modulation of HIV-specific CD8 + T cell function .
2105169	0	CD4	22,25	CD8	26,29	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Frequency analysis of CD4 + CD8 + T cells cloned with IL-4 .
21092106	0	CD4	0,3	CD8	79,82	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|induce induce|nmod|targets targets|compound|END_ENTITY	CD4 + CD25 + T regulatory cells from FIV + cats induce a unique anergic profile in CD8 + lymphocyte targets .
21098236	0	CD4	84,87	CD8	0,3	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	colitis|nummod|START_ENTITY prevent|dobj|colitis +|ccomp|prevent +|nsubj|CD122 CD122|compound|END_ENTITY	CD8 + CD122 + regulatory T cells -LRB- Tregs -RRB- and CD4 + Tregs cooperatively prevent and cure CD4 + cell-induced colitis .
21108468	0	CD4	0,3	CD8	45,48	CD4	CD8	920	925	Gene	Gene	Treg|compound|START_ENTITY regulate|nsubj|Treg regulate|dobj|contribution contribution|nmod|subsets subsets|compound|END_ENTITY	CD4 + CD25 + Treg regulate the contribution of CD8 + T-cell subsets in repopulation of the lymphopenic environment .
21151195	0	CD4	34,37	CD8	26,29	CD4	CD8	920	925	Gene	Gene	memory|compound|START_ENTITY +|nmod|memory +|compound|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21151195	0	CD4	72,75	CD8	26,29	CD4	CD8	920	925	Gene	Gene	expansion|nummod|START_ENTITY supports|dobj|expansion supports|nsubj|cells cells|amod|co-stimulation co-stimulation|nmod|+ +|compound|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21165245	0	CD4	52,55	CD8	79,82	CD4	CD8	920	925	Gene	Gene	T-cells|compound|START_ENTITY Balance|nmod|T-cells 2|dobj|Balance 2|nmod|T-cells T-cells|compound|END_ENTITY	Association of Intracellular T -LRB- H -RRB- 1-T -LRB- H -RRB- 2 Balance in CD4 + T-cells and MIP-1a in CD8 + T-cells with Disease Severity in Adults with Dengue .
2120773	0	CD4	84,87	CD8	70,73	CD4	CD8	920	925	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Inhibition Inhibition|nmod|expression expression|nmod|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
2125178	0	CD4	28,31	CD8	22,25	CD4	CD8	920	925	Gene	Gene	-|compound|START_ENTITY +|dep|- +|compound|END_ENTITY	Cytotoxic/suppressor -LRB- CD8 + , CD4 - -RRB- cutaneous_T-cell_lymphoma with aggressive course .
21263406	0	CD4	6,9	CD8	12,15	CD4	CD8	920	925	Gene	Gene	+|nsubj|START_ENTITY +|dobj|+ +|compound|END_ENTITY	Local CD4 + , CD8 + and CD56 + reactions to lung_cancer in regard to pathohistological type and clinical stage .
21264321	0	CD4	71,74	CD8	51,54	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY induce|nmod|cells induce|dobj|cells cells|compound|END_ENTITY	Liposome-coupled peptides induce long-lived memory CD8 T cells without CD4 T cells .
21287552	0	CD4	67,70	CD8	72,75	CD4	CD8	920	925	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|END_ENTITY	Characterization of the immunoregulatory function of human TCR-ab + CD4 - CD8 - double-negative T cells .
21312192	0	CD4	79,82	CD8	0,3	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY share|nmod|cells share|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
2140062	0	CD4	55,58	CD8	68,71	CD4	CD8	920	925	Gene	Gene	T4|appos|START_ENTITY T4|appos|END_ENTITY	Expansion of a lymphocyte population co-expressing T4 -LRB- CD4 -RRB- and T8 -LRB- CD8 -RRB- antigens in the peripheral blood of a normal adult male .
2141037	0	CD4	17,20	CD8	22,25	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Double-negative -LRB- CD4 - CD8 - -RRB- T cells with an alpha/beta T cell receptor .
2145216	0	CD4	23,26	CD8	94,97	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY cycling|dobj|cells Elimination|acl|cycling releases|nsubj|Elimination releases|dobj|cells cells|compound|END_ENTITY	Elimination of cycling CD4 + suppressor T cells with an anti-mitotic drug releases non-cycling CD8 + T cells to cause regression of an advanced_lymphoma .
21474552	0	CD4	24,27	CD8	91,94	CD4	CD8	920	925	Gene	Gene	deficiency|compound|START_ENTITY deficiency|nmod|induction induction|nmod|responses responses|nummod|END_ENTITY	IL-15 ex vivo overcomes CD4 + T cell deficiency for the induction of human antigen-specific CD8 + T cell responses .
21490785	0	CD4	113,116	CD8	0,3	CD4	CD8	920	925	Gene	Gene	<|compound|START_ENTITY ART|nmod|< Initiated|dobj|ART Adults|acl:relcl|Initiated Responses|nmod|Adults Responses|nsubj|T-Cell T-Cell|compound|END_ENTITY	CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells < 200 Cell / L : The DART Trial STI Substudy .
21502514	0	CD4	0,3	CD8	37,40	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY control|nsubj|cells control|dobj|differentiation differentiation|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasis .
21518973	0	CD4	0,3	CD8	67,70	CD4	CD8	920	925	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|dispensable dispensable|nmod|lung_inflammation lung_inflammation|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
21611103	0	CD4	15,18	CD8	20,23	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dual-Positive -LRB- CD4 + / CD8 + -RRB- Acute Adult_T-Cell_Leukemia / Lymphoma Associated with Complex Karyotype and Refractory Hypercalcemia : Case Report and Literature Review .
21622860	0	CD4	10,13	CD8	53,56	CD4	CD8	920	925	Gene	Gene	+|nsubj|START_ENTITY +|nmod|responses responses|nummod|END_ENTITY	Cytotoxic CD4 + T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition .
21652515	0	CD4	0,3	CD8	91,94	CD4	CD8	920	925	Gene	Gene	FoxP3|compound|START_ENTITY +|nsubj|FoxP3 +|ccomp|enhance enhance|dobj|activity activity|nmod|CD28-CTL CD28-CTL|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
21738737	0	CD4	91,94	CD8	54,57	CD4	CD8	920	925	Gene	Gene	responses|compound|START_ENTITY triggered|nmod|responses triggered|nsubj|induction induction|nmod|cells cells|compound|END_ENTITY	Physiological induction of regulatory Qa-1-restricted CD8 + T cells triggered by endogenous CD4 + T cell responses .
21809071	0	CD4	76,79	CD8	81,84	CD4	CD8	920	925	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Good response to HBsAg vaccine in dialysis patients is associated with high CD4 + / CD8 + ratio .
21858238	0	CD4	98,101	CD8	102,105	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chagasic thymic atrophy does not affect negative selection but results in the export of activated CD4 + CD8 + T cells in severe forms of human disease .
21881481	0	CD4	36,39	CD8	10,13	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY activation|nmod|T-cell activation|nsubj|Impact Impact|nmod|T-cell T-cell|compound|END_ENTITY	Impact of CD8 + T-cell activation on CD4 + T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy .
21886854	0	CD4	10,13	CD8	15,18	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	Increased CD4 + / CD8 + double-positive T cells in chronic Chagasic patients .
21919996	0	CD4	41,44	CD8	80,83	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY normalization|nmod|+ influencing|dobj|normalization T-cell|dep|influencing T-cell|compound|END_ENTITY	Factors influencing the normalization of CD4 + T-cell count , percentage and CD4 + / CD8 + T-cell ratio in HIV-infected patients on long-term suppressive antiretroviral therapy .
22002875	0	CD4	102,105	CD8	25,28	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY killing|nmod|cells model|dep|killing model|nmod|cells cells|compound|END_ENTITY	A clonal model for human CD8 + regulatory T cells : unrestricted contact-dependent killing of activated CD4 + T cells .
22051534	0	CD4	121,124	CD8	125,128	CD4	CD8	920	925	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Notch induces human T-cell receptor y + thymocytes to differentiate along a parallel , highly proliferative and bipotent CD4 CD8 double-positive pathway .
22067371	0	CD4	53,56	CD8	57,60	CD4	CD8	920	925	Gene	Gene	status|nmod|START_ENTITY Differences|nmod|status Differences|dep|ratio ratio|nummod|END_ENTITY	Differences according to gender and health status in CD4 : CD8 ratio in a sample of community-dwelling oldest old .
22116827	0	CD4	7,10	CD8	59,62	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY induce|nsubj|cells induce|nmod|cells cells|nummod|END_ENTITY	Memory CD4 T cells induce selective expression of IL-27 in CD8 + dendritic cells and regulate homeostatic naive T cell proliferation .
22160724	0	CD4	17,20	CD8	51,54	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY help|nsubj|T-cell help|ccomp|exhausted exhausted|dobj|cells cells|compound|END_ENTITY	Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral_infection .
22190592	0	CD4	118,121	CD8	122,125	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|ratios ratios|nummod|END_ENTITY	Expansion of a CD8 -LRB- + -RRB- PD-1 -LRB- + -RRB- replicative senescence phenotype in early stage CLL patients is associated with inverted CD4 : CD8 ratios and disease progression .
22190592	0	CD4	118,121	CD8	15,18	CD4	CD8	920	925	Gene	Gene	associated|nmod|START_ENTITY replicative|ccomp|associated replicative|nsubj|Expansion Expansion|nmod|PD-1 PD-1|compound|END_ENTITY	Expansion of a CD8 -LRB- + -RRB- PD-1 -LRB- + -RRB- replicative senescence phenotype in early stage CLL patients is associated with inverted CD4 : CD8 ratios and disease progression .
22373353	0	CD4	0,3	CD8	68,71	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY FoxP3|nsubj|CD25 FoxP3|dobj|cells cells|dep|suppress suppress|dobj|cytotoxicity cytotoxicity|nmod|cells cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress cytotoxicity of CD8 -LRB- + -RRB- effector T cells : implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level .
22393155	0	CD4	60,63	CD8	24,27	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY dependence|nmod|help differ|nmod|dependence T|ccomp|differ T|nsubj|END_ENTITY	MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse_polyomavirus_infection .
22422886	0	CD4	161,164	CD8	122,125	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY absence|nmod|T prevents|nmod|absence prevents|dobj|memory memory|amod|IL-12-mediated IL-12-mediated|dep|loss loss|nmod|T T|compound|END_ENTITY	CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8 -LRB- + -RRB- T cell memory in the absence of CD4 -LRB- + -RRB- T cell help .
22461689	0	CD4	0,3	CD8	4,7	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD4 + CD8 + T cells represent a significant portion of the anti-HIV T cell response to acute_HIV_infection .
22499005	0	CD4	9,12	CD8	13,16	CD4	CD8	920	925	Gene	Gene	T-lymphocyte|compound|START_ENTITY T-lymphocyte|compound|END_ENTITY	Study of CD4 + CD8 + double positive T-lymphocyte phenotype and function in Indian patients infected with HIV-1 .
22609353	0	CD4	60,63	CD8	64,67	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22640559	0	CD4	67,70	CD8	71,74	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4 + CD8 + thymocytes .
22688448	0	CD4	38,41	CD8	43,46	CD4	CD8	920	925	Gene	Gene	T-cell_large_granular_lymphocytic_leukemia|compound|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|dep|weak weak|dep|END_ENTITY	Monoclonal_B-cell_lymphocytosis -LRB- MBL , CD4 + / CD8 weak T-cell_large_granular_lymphocytic_leukemia -LRB- T-LGL_leukemia -RRB- and monoclonal_gammopathy_of_unknown_significance -LRB- MGUS -RRB- : molecular and flow cytometry characterization of three concomitant hematological_disorders .
22691754	0	CD4	129,132	CD8	138,141	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Molecules|nmod|+ Ratio|nmod|Molecules Ratio|dep|In-Vitro In-Vitro|compound|END_ENTITY	Evaluation of Ginger -LRB- Zingiber officinale Roscoe -RRB- Bioactive Compounds in Increasing the Ratio of T-cell Surface Molecules of CD3 + CD4 + : CD3 + CD8 + In-Vitro .
22711904	0	CD4	67,70	CD8	33,36	CD4	CD8	920	925	Gene	Gene	decline|compound|START_ENTITY rate|nmod|decline predicts|dobj|rate predicts|nsubj|capacity capacity|nmod|cells cells|compound|END_ENTITY	Antiviral inhibitory capacity of CD8 + T cells predicts the rate of CD4 + T-cell decline in HIV-1_infection .
22730529	0	CD4	73,76	CD8	24,27	CD4	CD8	920	925	Gene	Gene	differentiation|compound|START_ENTITY silencing|nmod|differentiation silencing|nmod|genes genes|nummod|END_ENTITY	Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation .
22781761	0	CD4	4,7	CD8	57,60	CD4	CD8	920	925	Gene	Gene	signal|compound|START_ENTITY transmitted|nsubjpass|signal transmitted|nmod|T-cells T-cells|compound|END_ENTITY	The CD4 T-cell help signal is transmitted from APC to CD8 T-cells via CD27-CD70 interactions .
22789871	0	CD4	7,10	CD8	11,14	CD4	CD4	920	403931(Tax:9615)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Canine CD4 + CD8 + double positive T cells in peripheral blood have features of activated T cells .
22802109	0	CD4	44,47	CD8	51,54	CD4	CD8	920	925	Gene	Gene	use|nmod|START_ENTITY use|dep|ratio ratio|compound|END_ENTITY	Combined use of etanercept and MTX restores CD4 / CD8 ratio and Tregs in spleen and thymus in collagen-induced_arthritis .
22823432	0	CD4	12,15	CD8	16,19	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Extrathymic CD4 + CD8 + lymphocytes in Chagas_disease : possible relationship with an immunoendocrine imbalance .
22871805	0	CD4	20,23	CD8	69,72	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY control|nsubj|cells control|dobj|generation generation|nmod|memory memory|amod|functional functional|dep|END_ENTITY	FoxP3 regulatory CD4 T cells control the generation of functional CD8 memory .
23018435	0	CD4	130,133	CD8	55,58	CD4	CD8	920	925	Gene	Gene	recovery|compound|START_ENTITY individuals|nmod|recovery effects|nmod|individuals effects|nmod|cells cells|compound|END_ENTITY	Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery .
23029357	0	CD4	9,12	CD8	13,16	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Immature CD4 + CD8 + thymocytes are preferentially infected by measles_virus in human thymic organ cultures .
23034272	0	CD4	49,52	CD8	55,58	CD4	CD8	920	925	Gene	Gene	levels|nmod|START_ENTITY load|appos|levels Correlation|nmod|load Correlation|dep|lymphocytes lymphocytes|compound|END_ENTITY	Correlation between viral load , plasma levels of CD4 - CD8 T lymphocytes and AIDS-related_oral_diseases : a multicentre study on 30 HIV + children in the HAART era .
23041830	0	CD4	0,3	CD8	20,23	CD4	CD8	920	925	Gene	Gene	helper|nsubj|START_ENTITY helper|dobj|cells cells|appos|cells cells|nummod|END_ENTITY	CD4 helper T cells , CD8 cytotoxic T cells , and FOXP3 -LRB- + -RRB- regulatory T cells with respect to lethal prostate_cancer .
23239806	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	reference|compound|START_ENTITY reference|compound|END_ENTITY	CD4 + CD8 + T cell reference values in the Mexico City population .
2328939	0	CD4	1,4	CD8	48,51	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY support|nsubj|cells support|dobj|cells cells|compound|END_ENTITY	-LSB- CD4 + T cells restricted by DQ not by DR support CD8 + T cells to grow -RSB- .
23321919	0	CD4	48,51	CD8	0,3	CD4	CD8	920	925	Gene	Gene	IFNy|compound|START_ENTITY injury|nmod|IFNy granzyme_B|dep|injury granzyme_B|compound|END_ENTITY	CD8 -LRB- + -RRB- granzyme_B -LRB- + -RRB- - mediated tissue injury vs. CD4 -LRB- + -RRB- IFNy -LRB- + -RRB- - mediated parasite killing in human cutaneous_leishmaniasis .
23324275	0	CD4	38,41	CD8	45,48	CD4	CD8	920	925	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Frequency of T-cell FoxP3 Treg and CD4 / CD8 PD-1 expression is related to HBeAg seroconversion in hepatitis_B patients on pegylated interferon .
23333732	0	CD4	139,142	CD8	83,86	CD4	CD8	920	925	Gene	Gene	CD8|compound|START_ENTITY involvement|nmod|CD8 T|nmod|involvement T|dep|developed developed|nmod|END_ENTITY	WITHDRAWN : The majority of T cells , including Treg cells , are developed from CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T progenitor cells without the involvement of the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage in the thymus .
23333732	0	CD4	77,80	CD8	145,148	CD4	CD8	920	925	Gene	Gene	CD8|compound|START_ENTITY developed|nmod|CD8 T|dep|developed T|nmod|involvement involvement|nmod|END_ENTITY	WITHDRAWN : The majority of T cells , including Treg cells , are developed from CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T progenitor cells without the involvement of the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage in the thymus .
23408789	0	CD4	6,9	CD8	12,15	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Local CD4 + , CD8 + and CD56 + T-lymphocite Reaction on Primary Lung_Cancer .
2346908	0	CD4	108,111	CD8	114,117	CD4	CD8	920	925	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
23562575	0	CD4	23,26	CD8	28,31	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The increased ratio of CD4 + / CD8 + was positively correlated with inflammation in hepatitis_C patients with metabolic_syndrome .
23800602	0	CD4	0,3	CD8	7,10	CD4	CD8	920	925	Gene	Gene	/|nsubj|START_ENTITY /|iobj|- -|compound|END_ENTITY	CD4 -LRB- - -RRB- / CD8 -LRB- - -RRB- variant of T-cell_large_granular_lymphocytic_leukemia or hepatosplenic_T-cell_lymphoma : a clinicopathologic dilemma .
23835849	0	CD4	0,3	CD8	97,100	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY use|nsubj|cells use|xcomp|counteract counteract|dobj|suppression suppression|nmod|responses responses|compound|END_ENTITY	CD4 + T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8 + T cell responses to influenza .
23846565	0	CD4	98,101	CD8	18,21	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY reservoir|nmod|cells influences|dobj|reservoir influences|nsubj|Susceptibility Susceptibility|nmod|killing killing|compound|END_ENTITY	Susceptibility to CD8 T-cell-mediated killing influences the reservoir of latently HIV-1-infected CD4 T cells .
23858460	0	CD4	41,44	CD8	45,48	CD4	CD8	920	925	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Asymmetric thymocyte death underlies the CD4 : CD8 T-cell ratio in the adaptive immune system .
23874581	0	CD4	142,145	CD8	86,89	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	ICOS|compound|START_ENTITY frequency|nmod|ICOS controls|nmod|frequency controls|nmod|induction induction|compound|END_ENTITY	Mesothelin virus-like particle immunization controls pancreatic_cancer growth through CD8 + T cell induction and reduction in the frequency of CD4 + foxp3 + ICOS - regulatory T cells .
23971203	0	CD4	54,57	CD8	59,62	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effect of T-2_toxin on percentages of CD4 + , CD8 + , CD4 + CD8 + and CD21 + lymphocytes , and mRNA expression levels of selected cytokines in porcine ileal Peyer 's patches .
24007533	0	CD4	4,7	CD8	8,11	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	The CD4 : CD8 ratio is associated with markers of age-associated_disease in virally suppressed HIV-infected patients with immunological recovery .
24114780	0	CD4	15,18	CD8	72,75	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY maintain|nsubj|cells maintain|dobj|cells cells|compound|END_ENTITY	Tumor-specific CD4 + T cells maintain effector and memory_tumor-specific CD8 + T cells .
24204912	0	CD4	14,17	CD8	18,21	CD4	CD8	920	925	Gene	Gene	Predictors|nmod|START_ENTITY Predictors|dep|normalization normalization|compound|END_ENTITY	Predictors of CD4 : CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy .
24222014	0	CD4	62,65	CD8	89,92	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|suppress suppress|dobj|allocytotoxicity allocytotoxicity|nmod:poss|cells cells|compound|END_ENTITY	Mycophenolic_acid-treated dendritic cells generate regulatory CD4 + T cells that suppress CD8 + T cells ' allocytotoxicity .
24240189	0	CD4	120,123	CD8	124,127	CD4	CD8	920	925	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4 + CD8 + double-positive cell .
24244610	0	CD4	30,33	CD8	14,17	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY T|nmod|+ T|nsubj|ratios ratios|nmod|+ +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24292234	0	CD4	125,128	CD8	97,100	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|nmod|cells cells|nummod|END_ENTITY	Necrotizing_lymphadenitis -LRB- NEL -RRB- is a systemic_disease characterized by blastic transformation of CD8 + cells and apoptosis of CD4 + cells .
24297179	0	CD4	110,113	CD8	115,118	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	generation|nmod|START_ENTITY CD8|nmod|generation cAMP_responsive_element_modulator|nmod|CD8 cAMP_responsive_element_modulator|dep|END_ENTITY	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
24297179	0	CD4	110,113	CD8	76,79	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	generation|nmod|START_ENTITY END_ENTITY|nmod|generation	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
2435832	0	CD4	73,76	CD8	79,82	CD4	CD8	920	925	Gene	Gene	-|compound|START_ENTITY expressed|nmod|- expressed|advmod|END_ENTITY	The T cell antigen receptor complex expressed on normal peripheral blood CD4 - , CD8 - T lymphocytes .
24387802	0	CD4	66,69	CD8	0,3	CD4	CD8	920	925	Gene	Gene	reactivity|compound|START_ENTITY exists|nsubj|reactivity unique|advcl|exists unique|nsubj|reactivity reactivity|compound|END_ENTITY	CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes .
24391889	0	CD4	106,109	CD8	12,15	CD4	CD8	920	925	Gene	Gene	recovery|compound|START_ENTITY predict|dobj|recovery predict|nsubj|percentages percentages|compound|END_ENTITY	Higher CD27 + CD8 + T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4 + T cell recovery in treated HIV_infection .
24504177	0	CD4	13,16	CD8	17,20	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	The inverted CD4 : CD8 ratio is associated with cytomegalovirus , poor cognitive and functional states in older adults .
24531173	1	CD4	34,37	CD8	39,42	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	CD4 + / CD8 + ratio and CD4 + percentage as surrogate markers for more complex immunological features .
24551107	0	CD4	9,12	CD8	43,46	CD4	CD8	920	925	Gene	Gene	CD8|compound|START_ENTITY T|nsubj|CD8 T|ccomp|suppress suppress|dobj|response response|compound|END_ENTITY	TCRy -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T cells suppress the CD8 -LRB- + -RRB- T-cell response to hepatitis_B virus peptides , and are associated with viral control in chronic hepatitis_B .
24559863	0	CD4	22,25	CD8	27,30	CD4	CD8	920	925	Gene	Gene	%|nummod|START_ENTITY utility|nmod|% utility|nmod|% %|nummod|END_ENTITY	Diagnostic utility of CD4 % : CD8 low % T-lymphocyte ratio to differentiate feline_immunodeficiency_virus _ -LRB- FIV -RRB- - infected from FIV-vaccinated cats .
24585895	0	CD4	11,14	CD8	113,116	CD4	CD8	920	925	Gene	Gene	+|nsubj|START_ENTITY +|advcl|clear clear|nsubj|cells cells|compound|END_ENTITY	Periportal CD4 + cell infiltration increases in HIV/hepatitis _ C_virus-coinfected patients commencing ART , whereas CD8 + cells clear from the liver .
24676325	0	CD4	9,12	CD8	13,16	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|ratio ratio|nummod|END_ENTITY	Inverted CD4 : CD8 ratio is not associated with three-year mortality in a sample of community-dwelling oldest old : the OCTABAIX immune study .
24676325	11	CD4	1380,1383	CD8	1384,1387	CD4	CD8	920	925	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	This risk profile did not change when introducing the CD4 : CD8 ratio into the calculation .
2477711	0	CD4	35,38	CD8	39,42	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intrathymic signalling in immature CD4 + CD8 + thymocytes results in tyrosine phosphorylation of the T-cell_receptor_zeta_chain .
24789784	0	CD4	109,112	CD8	27,30	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	cell|compound|START_ENTITY absence|nmod|cell infection|nmod|absence response|nmod|infection response|compound|END_ENTITY	Promotion of a subdominant CD8 T cell response during murine_gammaherpesvirus_68 infection in the absence of CD4 T cell help .
24816636	0	CD4	81,84	CD8	86,89	CD4	CD8	920	925	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Clinical , immunological and treatment-related factors associated with normalised CD4 + / CD8 + T-cell ratio : effect of na ve and memory T-cell subsets .
24920189	0	CD4	87,90	CD8	94,97	CD4	CD8	920	925	Gene	Gene	Restoration|nmod|START_ENTITY Required|nmod|Restoration Required|nsubjpass|Homeostasis Homeostasis|compound|END_ENTITY	p38_Mitogen-Activated_Protein_Kinase is Required for Electroacupuncture Restoration of CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- Homeostasis and Cytokine Expression in a Rodent Model of Surgical Trauma .
2495184	0	CD4	57,60	CD8	0,3	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY replication|nmod|cells control|nmod|replication control|compound|END_ENTITY	CD8 + T lymphocyte control of HIV replication in cultured CD4 + cells varies among infected individuals .
2495346	0	CD4	0,3	CD8	36,39	CD4	CD8	920	925	Gene	Gene	percentage|nummod|START_ENTITY percentage|dep|ratio ratio|nummod|END_ENTITY	CD4 percentage , CD4 number , and CD4 : CD8 ratio in HIV_infection : which to choose and how to use .
25002529	0	CD4	126,129	CD8	131,134	CD4	CD8	920	925	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The catalytic activity of the mitogen-activated protein kinase extracellular_signal-regulated_kinase_3 is required to sustain CD4 + CD8 + thymocyte survival .
2517950	0	CD4	59,62	CD8	64,67	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Generation of syngeneic anti-tumour double negative cells -LRB- CD4 - CD8 - -RRB- , with cytotoxic activity against clones of different MHC class I expression .
25216453	0	CD4	110,113	CD8	38,41	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY autologous|dep|cells cells|dep|autologous cells|compound|END_ENTITY	PBMC of HIV-infected patients contain CD8 T cells that form conjugates with and kill HIV - _ infected autologous CD4 T cells .
2522047	0	CD4	138,141	CD8	155,158	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|acl|clones clones|nummod|END_ENTITY	Differential secretion of tumor_necrosis_factor-alpha and granulocyte/macrophage colony-stimulating factors but not interferon-gamma from CD4 + compared to CD8 + human T cell clones .
2523311	1	CD4	113,116	CD8	119,122	CD4	CD8	920	925	Gene	Gene	-|compound|START_ENTITY Induction|appos|- Induction|appos|subset subset|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD4	113,116	CD8	195,198	CD4	CD8	920	925	Gene	Gene	-|compound|START_ENTITY Induction|appos|- Induction|appos|+ +|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD4	189,192	CD8	119,122	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Induction|appos|+ Induction|appos|subset subset|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD4	189,192	CD8	195,198	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY Induction|appos|+ Induction|appos|+ +|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2524009	0	CD4	13,16	CD8	18,21	CD4	CD8	920	925	Gene	Gene	Isolation|nmod|START_ENTITY Isolation|dep|END_ENTITY	Isolation of CD4 - CD8 - mycobacteria-reactive T lymphocyte clones from rheumatoid_arthritis synovial fluid .
25245659	0	CD4	37,40	CD8	95,98	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY secretion|nmod|T cells|amod|secretion regulated|nsubjpass|cells regulated|advcl|cells cells|compound|END_ENTITY	Granzyme_B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells .
2528005	0	CD4	28,31	CD8	37,40	CD4	CD8	920	925	Gene	Gene	Adult_T_cell_leukemia|nmod|START_ENTITY Adult_T_cell_leukemia|dep|END_ENTITY	-LSB- Adult_T_cell_leukemia with CD4 - and CD8 - -RSB- .
25308332	0	CD4	0,3	CD8	65,68	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|dep|formation formation|nmod|T T|compound|END_ENTITY	CD4 + T cell help guides formation of CD103 + lung-resident memory CD8 + T cells during influenza viral_infection .
25350657	0	CD4	0,3	CD8	38,41	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|ratio ratio|nummod|END_ENTITY	CD4 + , CD8 + , CD3 + cell counts and CD4 + / CD8 + ratio among patients with mycobacterial_diseases -LRB- Leprosy , Tuberculosis -RRB- , HIV_infections and Normal Healthy Adults : A comparative analysis of studies in different regions of India .
25355885	0	CD4	0,3	CD8	47,50	CD4	CD8	920	925	Gene	Gene	Help|compound|START_ENTITY Dispensable|nsubj|Help Dispensable|nmod|Memory Memory|compound|END_ENTITY	CD4 + T Cell Help Is Dispensable for Protective CD8 + T Cell Memory against Mousepox_Virus following Vaccinia_Virus Immunization .
25357997	0	CD4	148,151	CD8	153,156	CD4	CD8	920	925	Gene	Gene	Thymocytes|compound|START_ENTITY Thymocytes|dep|END_ENTITY	A Monoclonal Antibody Against the Extracellular Domain of Mouse and Human Epithelial_V-like_Antigen_1 Reveals a Restricted Expression Pattern Among CD4 - CD8 - Thymocytes .
2535856	0	CD4	17,20	CD8	67,70	CD4	CD8	920	925	Gene	Gene	activity|compound|START_ENTITY activity|acl|revealed revealed|nmod|elimination elimination|compound|END_ENTITY	A virus-specific CD4 + cell-mediated cytolytic activity revealed by CD8 + cell elimination regularly develops in uncloned human antiviral cell lines .
25360575	0	CD4	106,109	CD8	110,113	CD4	CD8	920	925	Gene	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Chronic_Inflammation in a Long-Term Cohort of HIV-Infected Patients According to the Normalization of the CD4 : CD8 Ratio .
25366203	0	CD4	6,9	CD8	13,16	CD4	CD8	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD3 + , CD4 + _ CD8 + tumour infiltrating lymphocytes -LRB- TILs -RRB- are predictors of favourable survival outcome in infiltrating ductal_carcinoma of breast .
25378489	0	CD4	8,11	CD8	77,80	CD4	CD8	920	925	Gene	Gene	licensing|compound|START_ENTITY heralds|nsubj|licensing heralds|dobj|immunity immunity|compound|END_ENTITY	Cognate CD4 T-cell licensing of dendritic cells heralds anti-cytomegalovirus CD8 T-cell immunity after human allogeneic umbilical cord_blood_transplantation .
25395939	0	CD4	37,40	CD8	43,46	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|cells cells|nummod|END_ENTITY	Peripheral blood lymphocyte subsets -LRB- CD4 + , CD8 + T cells -RRB- , leptin level and weight_loss after laparoscopic greater curvature plication in morbidly obese patients .
25397469	0	CD4	4,7	CD8	8,11	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	The CD4 : CD8 ratio is associated with IMT progression in HIV-infected patients on antiretroviral treatment .
25444817	0	CD4	0,3	CD8	66,69	CD4	CD8	920	925	Gene	Gene	T-cells|compound|START_ENTITY transduced|nsubj|T-cells transduced|ccomp|induce induce|dep|resulting resulting|nsubj|responses responses|compound|END_ENTITY	CD4 T-cells transduced with CD80 and 4-1BBL mRNA induce long-term CD8 T-cell responses resulting in potent antitumor effects .
25454082	0	CD4	61,64	CD8	13,16	CD4	CD8	920	925	Gene	Gene	develop|nmod|START_ENTITY double-positive|ccomp|develop double-positive|nsubj|END_ENTITY	Canine CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- double-positive T cells can develop from CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
25485147	0	CD4	76,79	CD8	86,89	CD8	CD8	925	925	Gene	Gene	START_ENTITY|dep|Ratio Ratio|compound|END_ENTITY	Establishment of Normal Reference Intervals for CD3 -LRB- + -RRB- , CD4 -LRB- + -RRB- , CD8 -LRB- + -RRB- , and CD4 -LRB- + -RRB- to CD8 -LRB- + -RRB- Ratio of T Lymphocytes in HIV Negative Adults from University of Gondar Hospital , North West Ethiopia .
25488445	0	CD4	16,19	CD8	20,23	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Double positive CD4 + CD8 + T cells : key suppressive role in the production of autoantibodies in systemic_lupus_erythematosus .
2550249	0	CD4	52,55	CD8	57,60	CD4	CD8	920	925	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|dep|END_ENTITY	Analysis of T cell receptor gamma chains from adult CD4 - CD8 - thymocytes .
25536344	0	CD4	41,44	CD8	46,49	CD4	CD8	920	925	Gene	Gene	Thymocytes|compound|START_ENTITY Thymocytes|compound|END_ENTITY	T Cell Factor-1 Controls the Lifetime of CD4 + CD8 + Thymocytes In Vivo and Distal T Cell Receptor a-Chain Rearrangement Required for NKT Cell Development .
25640181	0	CD4	46,49	CD8	31,34	CD4	CD8	920	925	Gene	Gene	Cells|compound|START_ENTITY Cross-Differentiation|nmod|Cells Cross-Differentiation|nmod|Lineage Lineage|compound|END_ENTITY	Cross-Differentiation from the CD8 Lineage to CD4 T Cells in the Gut-Associated Microenvironment with a Nonessential Role of Microbiota .
2564859	0	CD4	34,37	CD8	40,43	CD4	CD8	920	925	Gene	Gene	Responsiveness|nmod|START_ENTITY Responsiveness|amod|END_ENTITY	Responsiveness of fetal and adult CD4 - , CD8 - thymocytes to T cell activation .
2570049	0	CD4	67,70	CD8	20,23	CD4	CD8	920	925	Gene	Gene	line|compound|START_ENTITY T|nmod|line T|nsubj|Activation Activation|nmod|suppressor suppressor|compound|END_ENTITY	Activation of human CD8 + suppressor T cells by an antigen-specific CD4 + T-cell line in vitro .
25715104	0	CD4	70,73	CD8	95,98	CD4	CD8	920	925	Gene	Gene	count|compound|START_ENTITY recovery|nmod|count Influence|nmod|recovery Influence|dep|ratio ratio|nummod|END_ENTITY	Influence of lifelong cumulative_HIV_viremia on long-term recovery of CD4 + cell count and CD4 + / CD8 + ratio among patients on combination antiretroviral therapy .
2571681	0	CD4	12,15	CD8	16,19	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD8 + cells in myasthenia_gravis : supplementary immunological parameter for long-term prognosis .
25764310	0	CD4	76,79	CD8	133,136	CD4	CD8	920	925	Gene	Gene	Counts|compound|START_ENTITY HIV_Viraemic_Controllers|nmod|Counts Outcome|nmod|HIV_Viraemic_Controllers Determined|nsubj|Outcome Determined|nmod|T-Cell-Mediated_HIV_Suppression T-Cell-Mediated_HIV_Suppression|compound|END_ENTITY	Clinical Outcome of HIV_Viraemic_Controllers and Noncontrollers with Normal CD4 Counts Is Exclusively Determined by Antigen-Specific CD8 + T-Cell-Mediated_HIV_Suppression .
25946343	0	CD4	37,40	CD8	43,46	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|Cells Cells|compound|END_ENTITY	Peripheral Blood Lymphocyte Subsets -LRB- CD4 + , CD8 + T Cells , NK Cells -RRB- in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy .
25946343	0	CD4	37,40	CD8	43,46	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|Cells Cells|compound|END_ENTITY	Peripheral Blood Lymphocyte Subsets -LRB- CD4 + , CD8 + T Cells , NK Cells -RRB- in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy .
26022412	0	CD4	31,34	CD8	0,3	CD4	CD8	920	925	Gene	Gene	START_ENTITY|compound|T T|compound|END_ENTITY	CD8 -LRB- + -RRB- T activation attenuates CD4 -LRB- + -RRB- T proliferation through dendritic cells modification .
26022412	0	CD4	31,34	CD8	0,3	CD4	CD8	920	925	Gene	Gene	START_ENTITY|compound|T T|compound|END_ENTITY	CD8 -LRB- + -RRB- T activation attenuates CD4 -LRB- + -RRB- T proliferation through dendritic cells modification .
26034206	0	CD4	0,3	CD8	36,39	CD4	CD8	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY resemble|nsubj|lymphocytes resemble|ccomp|lymphocytes lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + CD28null T lymphocytes resemble CD8 + CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients .
26051633	0	CD4	13,16	CD8	17,20	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	The inverted CD4 : CD8 ratio is associated with gender-related changes in oxidative stress during aging .
26116499	0	CD4	0,3	CD8	104,107	CD4	CD8	920	925	Gene	Gene	Substantially|compound|START_ENTITY Augments|nsubj|Substantially Augments|dobj|Potential Potential|nmod|Blockade Blockade|nmod|Cells Cells|compound|END_ENTITY	CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells .
26130226	0	CD4	0,3	CD8	4,7	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|ratio ratio|nummod|END_ENTITY	CD4 : CD8 ratio as a frontier marker for clinical outcome , immune_dysfunction and viral reservoir size in virologically suppressed HIV-positive patients .
26147684	0	CD4	23,26	CD8	118,121	CD4	CD8	920	925	Gene	Gene	cells|amod|START_ENTITY Production|dep|cells promotes|nmod|Production promotes|dobj|maturation maturation|nmod|END_ENTITY	Production of IL-10 by CD4 -LRB- + -RRB- regulatory T cells during the resolution of infection promotes the maturation of memory CD8 -LRB- + -RRB- T cells .
26155145	0	CD4	0,3	CD8	16,19	CD4	CD8	920	925	Gene	Gene	CD25|compound|START_ENTITY CD25|appos|CD28 CD28|compound|END_ENTITY	CD4 + CD25 -LRB- high -RRB- , CD8 + CD28 - cells and thyroid autoantibodies in breast_cancer patients .
26183926	0	CD4	85,88	CD8	113,116	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY II|nmod|T Expression|nmod|II Expression|dep|Cells Cells|acl:relcl|+ +|nsubj|END_ENTITY	Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4 + T - Cells , Which Dampen CD8 + T-cell Antitumor Reactivity .
26191056	0	CD4	0,3	CD8	4,7	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|ratio ratio|nummod|END_ENTITY	CD4 : CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1_infection : findings from an African cohort with prospective data .
26243260	0	CD4	91,94	CD8	98,101	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Acute exacerbations of chronic_obstructive_pulmonary_disease are associated with decreased CD4 + _ CD8 + T cells and increased growth ___ differentiation_factor-15 -LRB- GDF-15 -RRB- in peripheral blood .
26243260	0	CD4	91,94	CD8	98,101	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Acute exacerbations of chronic_obstructive_pulmonary_disease are associated with decreased CD4 + _ CD8 + T cells and increased growth ___ differentiation_factor-15 -LRB- GDF-15 -RRB- in peripheral blood .
26253341	0	CD4	83,86	CD8	87,90	CD4	CD8	920	925	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Host , disease , and antiretroviral factors are associated with normalization of the CD4 : CD8 ratio after initiating antiretroviral therapy .
26260525	0	CD4	10,13	CD8	15,18	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|T-cell_lymphoma T-cell_lymphoma|dep|END_ENTITY	Recurrent CD4 - / CD8 - peripheral T-cell_lymphoma with change in cytoarchitectural features and immunophenotype over the course of disease .
26309078	0	CD4	33,36	CD8	18,21	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY lineage|nmod|cells lineage|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion of the CD8 lineage to CD4 T cells .
26315539	0	CD4	15,18	CD8	21,24	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Proportions of CD4 + , CD8 + and B cell subsets are not affected by exposure to HIV or to Cotrimoxazole prophylaxis in Malawian HIV-uninfected but exposed children .
26385221	0	CD4	42,45	CD8	46,49	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CD4 + CD28null and extra-thymic CD4 + CD8 + double positive T cells are independently associated with disease_damage in systemic_lupus_erythematosus patients .
26550040	0	CD4	95,98	CD8	41,44	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY shows|nmod|cells shows|nsubj|profiling profiling|nmod|cells cells|compound|END_ENTITY	Genome-wide DNA methylation profiling of CD8 + T cells shows a distinct epigenetic signature to CD4 + T cells in multiple_sclerosis patients .
26632470	0	CD4	1,4	CD8	8,11	CD4	CD8	920	925	Gene	Gene	T_cell_large_granular_lymphocyte_leukemia|compound|START_ENTITY T_cell_large_granular_lymphocyte_leukemia|compound|END_ENTITY	-LSB- CD4 CD8 TCRy T_cell_large_granular_lymphocyte_leukemia associated with b - _ thalassemia minor : one case report and literature review -RSB- .
26781939	0	CD4	25,28	CD8	43,46	CD4	CD8	920	925	Gene	Gene	role|nmod|START_ENTITY T|nsubj|role T|xcomp|memory memory|nsubj|cells cells|nmod|T T|compound|END_ENTITY	The multifaceted role of CD4 -LRB- + -RRB- T cells in CD8 -LRB- + -RRB- T cell memory .
26896482	0	CD4	61,64	CD8	148,151	CD4	CD8	920	925	Gene	Gene	Transcription|compound|START_ENTITY Signaled|dobj|Transcription Signaled|advcl|Differentiating Differentiating|nmod|Cells Cells|compound|END_ENTITY	Pillars Article : Coreceptor Reversal in the Thymus : Signaled CD4 +8 + Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8 + T Cells .
26896482	0	CD4	61,64	CD8	99,102	CD4	CD8	920	925	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Pillars Article : Coreceptor Reversal in the Thymus : Signaled CD4 +8 + Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8 + T Cells .
26912319	0	CD4	0,3	CD8	64,67	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	Help|compound|START_ENTITY Required|nsubjpass|Help Required|nmod|Proliferation Proliferation|compound|END_ENTITY	CD4 T Cell Help via B Cells Is Required for Lymphopenia-Induced CD8 T Cell Proliferation .
26939850	0	CD4	82,85	CD8	60,63	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY lineage|nmod|cells lineage|compound|END_ENTITY	Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance .
26959228	0	CD4	14,17	CD8	19,22	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|Correlate Correlate|nsubj|Counts Counts|compound|END_ENTITY	Hierarchy Low CD4 + / CD8 + T-Cell Counts and IFN-y Responses in HIV-1 + Individuals Correlate with Active TB and/or M.tb Co-Infection .
26959354	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	CD4 + / CD8 + ratio , age , and risk of serious noncommunicable_diseases in HIV-infected adults on antiretroviral therapy .
26965634	0	CD4	66,69	CD8	70,73	CD4	CD8	920	925	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	Interleukin-7 promotes human regulatory T cell development at the CD4 + CD8 + double-positive thymocyte stage .
27068801	0	CD4	18,21	CD8	78,81	CD4	CD8	920	925	Gene	Gene	role|nmod|START_ENTITY T|nsubj|role T|nmod|cells cells|compound|END_ENTITY	A role for CCR5 -LRB- + -RRB- CD4 T cells in cutaneous psoriasis and for CD103 -LRB- + -RRB- CCR4 -LRB- + -RRB- CD8 Teff cells in the associated systemic_inflammation .
27088803	1	CD4	77,80	CD8	26,29	CD4	CD8	920	925	Gene	Gene	cells|nummod|START_ENTITY inhibit|dobj|cells vesicles|xcomp|inhibit vesicles|nsubj|NOX2-loaded NOX2-loaded|compound|END_ENTITY	- CD8 + Tregs release NOX2-loaded vesicles to inhibit CD4 + T cells .
2783859	0	CD4	6,9	CD8	12,15	CD4	CD8	920	925	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|END_ENTITY	CD7 + , CD4 - , CD8 - acute leukemia : a syndrome of malignant pluripotent lymphohematopoietic cells .
2783889	6	CD4	818,821	CD8	823,826	CD4	CD8	920	925	Gene	Gene	reversed|dep|START_ENTITY +|amod|reversed was|nsubj|+ studied|ccomp|was +|dep|studied +|compound|END_ENTITY	In all the tumors studied there was a reversed CD4 + / CD8 + ratio as compared to that found in normal peripheral blood .
2787596	0	CD4	16,19	CD8	22,25	CD4	CD8	920	925	Gene	Gene	CD3|nummod|START_ENTITY case|nmod|CD3 case|parataxis|END_ENTITY	A case of CD3 + , CD4 - , CD8 - , WT31 - acute_T-cell_leukemia .
2790191	0	CD4	36,39	CD8	41,44	CD4	CD8	920	925	Gene	Gene	T-prolymphocytic|compound|START_ENTITY T-prolymphocytic|compound|END_ENTITY	Proliferative pathways in CD1 - CD3 + CD4 + CD8 + T-prolymphocytic leukemic cells : analysis with monoclonal antibodies and cytokines .
2828471	0	CD4	47,50	CD8	51,54	CD4	CD8	920	925	Gene	Gene	lymphocyte|compound|START_ENTITY lymphocyte|compound|END_ENTITY	Herpesvirus ateles immortalizes in vitro a CD3 + CD4 + CD8 + marmoset lymphocyte with NK function .
2886703	0	CD4	10,13	CD8	15,18	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY case|nmod|+ case|dep|END_ENTITY	A case of CD4 + / CD8 - adult T-cell_leukemia with good response to interferon-beta terminating as a CD4 + / CD8 + adult T-cell_lymphoma .
2950175	0	CD4	77,80	CD8	82,85	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Determination of co-expression of activation antigens on proliferating CD4 + , CD4 + CD8 + and CD8 + lymphocyte subsets by dual parameter flow cytometry .
2960546	0	CD4	129,132	CD8	63,66	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY expressed|nmod|+ END_ENTITY|acl:relcl|expressed	A novel serine proteinase -LRB- HuTSP -RRB- isolated from a cloned human CD8 + cytolytic T cell line is expressed and secreted by activated CD4 + and CD8 + lymphocytes .
2960737	0	CD4	50,53	CD8	55,58	CD4	CD8	920	925	Gene	Gene	mechanisms|nmod|START_ENTITY Analysis|nmod|mechanisms Analysis|dep|END_ENTITY	Analysis of signal transducing mechanisms in CD3 + CD4 - CD8 - cells expressing the putative T cell receptor gamma gene product .
2962747	0	CD4	74,77	CD8	14,17	CD4	CD8	920	925	Gene	Gene	+2|compound|START_ENTITY H4|nummod|+2 requirement|nmod|H4 has|dobj|requirement has|nsubj|Generation Generation|acl|END_ENTITY	Generation of CD8 -LRB- T8 -RRB- cytotoxic cells has a preferential requirement for CD4 +2 H4 - inducer cells .
2964483	0	CD4	107,110	CD8	112,115	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|dep|END_ENTITY	CD3-associated alpha/beta and gamma/delta heterodimeric receptors are expressed by distinct populations of CD4 - CD8 - thymocytes .
2970356	0	CD4	102,105	CD8	108,111	CD4	CD8	920	925	Gene	Gene	+|appos|START_ENTITY +|appos|END_ENTITY	Heterogeneity of lymphokine-activated killer -LRB- LAK -RRB- populations at the clonal level : both NK and CD3 + , CD4 - , CD8 - clones efficiently mediate tumor cell killing .
3108883	0	CD4	93,96	CD8	98,101	CD4	CD8	920	925	Gene	Gene	activity|nmod|START_ENTITY implication|nmod|activity gamma|dep|implication gamma|dep|END_ENTITY	The T-cell receptor gamma chain-CD3 complex : implication in the cytotoxic activity of a CD3 + CD4 - CD8 - human natural killer clone .
3110350	0	CD4	26,29	CD8	32,35	CD4	CD8	920	925	Gene	Gene	CD3|nummod|START_ENTITY END_ENTITY|nmod|CD3	Characterization of CD3 + , CD4 - , CD8 - clones expressing the putative T cell receptor gamma gene product .
3262830	0	CD4	46,49	CD8	23,26	CD4	CD8	920	925	Gene	Gene	clones|compound|START_ENTITY induction|nmod|clones induction|nummod|END_ENTITY	Interleukin-4 mediates CD8 induction on human CD4 + T-cell clones .
3297298	0	CD4	57,60	CD8	62,65	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	T-cell_prolymphocytic_leukemia with an unusual phenotype CD4 + CD8 + .
7479922	0	CD4	102,105	CD8	22,25	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY replication|nmod|cells suppression|nmod|replication suppression|compound|END_ENTITY	Interleukin_2 induces CD8 + T cell-mediated suppression of human immunodeficiency virus replication in CD4 + T cells and this effect overrides its ability to stimulate virus expression .
7482625	0	CD4	13,16	CD8	18,21	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	A decreasing CD4 + / CD8 + ratio after one month of treatment with stanazolol in postmenopausal women .
7518369	0	CD4	62,65	CD8	33,36	CD4	CD8	920	925	Gene	Gene	counts|nummod|START_ENTITY correlates|nmod|counts correlates|nsubj|Inhibition Inhibition|nmod|replication replication|nmod|cells cells|compound|END_ENTITY	Inhibition of HIV replication by CD8 + T cells correlates with CD4 counts and clinical stage of disease .
7518749	0	CD4	76,79	CD8	81,84	CD4	CD8	920	925	Gene	Gene	CD3|dep|START_ENTITY CD3|dep|END_ENTITY	Steel_factor -LRB- c-kit_ligand -RRB- stimulates the in vitro growth of immature CD3 - / CD4 - / CD8 - thymocytes : synergy with IL-7 .
7527813	0	CD4	70,73	CD8	75,78	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	The E2 molecule -LRB- CD99 -RRB- specifically triggers homotypic aggregation of CD4 + CD8 + thymocytes .
7528767	0	CD4	78,81	CD8	83,86	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
7529806	0	CD4	56,59	CD8	17,20	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY recognize|dobj|cells recognize|nsubj|cells cells|compound|END_ENTITY	Immunoregulatory CD8 + cells recognize antigen-activated CD4 + cells in myasthenia_gravis patients and in healthy controls .
7546905	0	CD4	30,33	CD8	113,116	CD4	CD8	920	925	Gene	Gene	Frequency|nmod|START_ENTITY +|nsubj|Frequency +|nmod|extent extent|nmod|apoptosis apoptosis|nmod|+ +|compound|END_ENTITY	Frequency of provirus-bearing CD4 + cells in HIV_type_1 infection correlates with extent of in vitro apoptosis of CD8 + but not of CD4 + cells .
7686224	0	CD4	90,93	CD8	25,28	CD4	CD8	920	925	Gene	Gene	levels|compound|START_ENTITY value|nmod|levels add|nmod|value add|nsubj|levels levels|nmod|cells cells|compound|END_ENTITY	Elevated levels of CD38 + CD8 + T cells in HIV_infection add to the prognostic value of low CD4 + T cell levels : results of 6 years of follow-up .
7688021	0	CD4	18,21	CD8	22,25	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Precursors of CD3 + CD4 + CD8 + cells in the human thymus are defined by expression of CD34 .
7688270	0	CD4	112,115	CD8	0,3	CD4	CD8	920	925	Gene	Gene	counts|nummod|START_ENTITY correlate|nmod|counts +|ccomp|correlate +|nsubj|+ +|compound|END_ENTITY	CD8 + CD38 + and CD8 + DR + peripheral blood_lymphoid_subsets_of_HIV-infected intravenous drug abusers correlate with CD4 + cell counts and proliferation to mitogens .
7697540	0	CD4	74,77	CD8	31,34	CD4	CD8	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY +|dep|lymphocytes +|compound|END_ENTITY	Alterations in levels of CD28 - / CD8 + suppressor cell precursor and CD45RO + / CD4 + memory T lymphocytes in the peripheral blood of multiple_sclerosis patients .
7700360	0	CD4	77,80	CD8	82,85	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Defective T-cell receptor signalling and positive selection of Vav-deficient CD4 + CD8 + thymocytes .
7706707	0	CD4	73,76	CD8	77,80	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intracellular signaling events during positive and negative selection of CD4 + CD8 + thymocytes in vitro .
7730608	0	CD4	30,33	CD8	34,37	CD4	CD8	920	925	Gene	Gene	maturation|nmod|START_ENTITY +|nmod|maturation +|nsubj|END_ENTITY	In vitro maturation of clonal CD4 + CD8 + cell lines in response to TCR engagement .
7734377	0	CD4	70,73	CD8	88,91	CD4	CD8	920	925	Gene	Gene	CD8|compound|START_ENTITY CD8|dep|+ +|compound|END_ENTITY	Identification of biclonal -LRB- duplex -RRB- leukaemic cells expressing either CD4 + / CD8 - or CD4 - / CD8 + from a patient with adult_T-cell_leukaemia / lymphoma .
7734377	0	CD4	83,86	CD8	88,91	CD4	CD8	920	925	Gene	Gene	CD8|dep|START_ENTITY CD8|dep|+ +|compound|END_ENTITY	Identification of biclonal -LRB- duplex -RRB- leukaemic cells expressing either CD4 + / CD8 - or CD4 - / CD8 + from a patient with adult_T-cell_leukaemia / lymphoma .
7790038	0	CD4	15,18	CD8	92,95	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY Requirement|nmod|cells Requirement|nmod|generation generation|nmod|END_ENTITY	Requirement of CD4 + T cells and antigen-presenting_cells for primary in vitro generation of CD8 + cytotoxic T cells against Ld-binding self-peptide p2Ca .
7803265	0	CD4	44,47	CD8	49,52	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Established IL-2-dependent double-negative -LRB- CD4 - CD8 - -RRB- TCR alpha beta/CD3 + ATL cells : induction of CD4 expression .
7803265	0	CD4	99,102	CD8	49,52	CD4	CD8	920	925	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression cells|dep|induction cells|appos|CD4 CD4|dep|- -|compound|END_ENTITY	Established IL-2-dependent double-negative -LRB- CD4 - CD8 - -RRB- TCR alpha beta/CD3 + ATL cells : induction of CD4 expression .
7822781	0	CD4	82,85	CD8	86,89	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Specific suppression by prostaglandin_E2 of activation-induced apoptosis of human CD4 + CD8 + T lymphoblasts .
7895174	0	CD4	100,103	CD8	6,9	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells lymphocyte|xcomp|expressed lymphocyte|nsubj|T T|compound|END_ENTITY	Human CD8 + T lymphocyte clones specific for T cell receptor V beta families expressed on autologous CD4 + T cells .
7901153	0	CD4	0,3	CD8	97,100	CD4	CD8	920	925	Gene	Gene	comodulated|nsubjpass|START_ENTITY comodulated|nmod|activation activation|nmod|line line|compound|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7901153	0	CD4	92,95	CD8	97,100	CD4	CD8	920	925	Gene	Gene	line|compound|START_ENTITY line|compound|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7902564	0	CD4	211,214	CD8	215,218	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Decreased signaling competence as a result of receptor overexpression : overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4 + CD8 + thymocytes .
7904456	0	CD4	74,77	CD8	78,81	CD4	CD8	395362(Tax:9031)	403158(Tax:9031)	Gene	Gene	START_ENTITY|dep|ratio ratio|nummod|END_ENTITY	Genetic analysis of four differing traits -LRB- MHC haplotype , tumor response , CD4 : CD8 ratio , ev 17 -RRB- in CB and CC congenic chickens .
7905840	0	CD4	62,65	CD8	82,85	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|parataxis|double double|nsubj|+ +|compound|END_ENTITY	Differential expression of PKC_alpha and PKC_beta isozymes in CD4 + , CD8 + and CD4 + / CD8 + double positive human T cells .
7907838	0	CD4	89,92	CD8	108,111	CD4	CD8	920	925	Gene	Gene	counts|compound|START_ENTITY obtaining|dobj|counts method|acl|obtaining Accuracy|nmod|method Accuracy|dep|END_ENTITY	Accuracy and cost-effectiveness of a one-tube , three-color method for obtaining absolute CD4 counts and CD4 : CD8 ratios .
7910843	0	CD4	73,76	CD8	77,80	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Thymic epithelial cells provide unique signals for positive selection of CD4 + CD8 + thymocytes in vitro .
7922370	0	CD4	93,96	CD8	113,116	CD4	CD8	920	925	Gene	Gene	T-cell|compound|START_ENTITY need|nmod|T-cell help|nsubj|need help|nmod|responses responses|compound|END_ENTITY	Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4 + T-cell help in CD8 + T-cell responses .
7930717	0	CD4	159,162	CD8	0,3	CD4	CD8	920	925	Gene	Gene	levels|compound|START_ENTITY associated|nmod|levels lymphocyte|parataxis|associated lymphocyte|nsubj|+ +|compound|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
7930717	0	CD4	159,162	CD8	111,114	CD4	CD8	920	925	Gene	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|cells cells|compound|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
7955559	0	CD4	53,56	CD8	58,61	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phenotypic heterogeneity of persistent expansions of CD4 + CD8 + T cells .
7966595	0	CD4	0,3	CD8	37,40	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY required|nsubjpass|cells required|xcomp|sustain sustain|dobj|responses responses|nummod|END_ENTITY	CD4 + T cells are required to sustain CD8 + cytotoxic T-cell responses during chronic viral_infection .
7967733	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	granular_lymphocytic_leukemia|compound|START_ENTITY granular_lymphocytic_leukemia|compound|END_ENTITY	CD4 + CD8 + granular_lymphocytic_leukemia arising in a patient with acute_myeloblastic_leukemia .
8041724	0	CD4	109,112	CD8	113,116	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4 + CD8 + thymocytes into mature T cells .
8049648	0	CD4	71,74	CD8	76,79	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Adult_T-cell_leukemia derived from S100_beta positive double-negative -LRB- CD4 - CD8 - -RRB- T cells .
8059546	0	CD4	15,18	CD8	20,23	CD4	CD8	920	925	Gene	Gene	study|nmod|START_ENTITY study|dep|ratio ratio|nummod|END_ENTITY	A study of the CD4 : CD8 ratio in peripheral T lymphocytes of rural Papua New Guineans : a reduced ratio assessed with regard to infectious agents .
8074498	0	CD4	92,95	CD8	97,100	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	+|compound|START_ENTITY cytotoxicity|nmod|+ requirement|nmod|cytotoxicity requirement|parataxis|subpopulations subpopulations|nsubj|+ +|compound|END_ENTITY	Signal requirement for induction of MHC-unrestricted antitumor cytotoxicity of human T cell CD4 + / CD8 + subpopulations .
8093893	0	CD4	141,144	CD8	145,148	CD4	CD8	920	925	Gene	Gene	+|nummod|START_ENTITY END_ENTITY|nmod:npmod|+	Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4 + CD8 - and CD4-CD8 - gamma/delta T cells .
8099013	0	CD4	20,23	CD8	25,28	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Killing of immature CD4 + CD8 + thymocytes in vivo by anti-CD3 or 5 ' - -LRB- N-ethyl -RRB- - carboxamide_adenosine is blocked by glucocorticoid_receptor antagonist RU-486 .
8100570	0	CD4	17,20	CD8	22,25	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Circulating CD3 + CD4 + CD8 + T lymphocytes in multiple_sclerosis .
8101541	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY thymocytes|compound|+ thymocytes|dep|END_ENTITY	CD4 + / CD8 - thymocytes dominate the fetal thymus treated with a combination of anti-T cell receptor-beta and anti-CD4 antibodies .
8223848	0	CD4	51,54	CD8	56,59	CD4	CD8	920	925	Gene	Gene	expansion|nmod|START_ENTITY occurrence|nmod|expansion occurrence|dep|END_ENTITY	Frequent occurrence of in vivo clonal expansion of CD4 - CD8 - T cells bearing T cell receptor alpha beta chains in adult humans .
8231237	0	CD4	128,131	CD8	100,103	CD4	CD8	12504(Tax:10090)	925	Gene	Gene	T-lymphocytes|compound|START_ENTITY +|nmod|T-lymphocytes +|compound|END_ENTITY	Cyclophosphamide treatment of an SJL murine B-cell_lymphoma increases the proportion of suppressive CD8 + over tumor-stimulatory CD4 + T-lymphocytes .
8244326	0	CD4	83,86	CD8	91,94	CD4	CD8	920	925	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	Small_lymphocytic_non-Hodgkin 's _ lymphoma of suppressor/cytotoxic T-cell phenotype -LSB- CD4 -LRB- - -RRB- , CD8 -LRB- + -RRB- -RSB- .
8260458	0	CD4	122,125	CD8	126,129	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Function of alpha beta TCR + intestinal intraepithelial lymphocytes : Th1 - and Th2-type cytokine production by CD4 + CD8 - and CD4 + CD8 + T cells for helper activity .
8289789	0	CD4	33,36	CD8	57,60	CD4	CD8	920	925	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene +|nsubj|expression +|dobj|cells cells|dep|T T|amod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	33,36	CD8	80,83	CD4	CD8	920	925	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene +|nsubj|expression +|dobj|cells cells|dep|T T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	52,55	CD8	57,60	CD4	CD8	920	925	Gene	Gene	gene|nmod|START_ENTITY expression|nmod|gene +|nsubj|expression +|dobj|cells cells|dep|T T|amod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	52,55	CD8	80,83	CD4	CD8	920	925	Gene	Gene	gene|nmod|START_ENTITY expression|nmod|gene +|nsubj|expression +|dobj|cells cells|dep|T T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	75,78	CD8	57,60	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD4	75,78	CD8	80,83	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8294878	0	CD4	22,25	CD8	26,29	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Negative selection of CD4 + CD8 + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 .
8364204	0	CD4	25,28	CD8	30,33	CD4	CD8	920	925	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Persistent expansions of CD4 + CD8 + peripheral blood T cells .
8370171	0	CD4	53,56	CD8	58,61	CD4	CD8	920	925	Gene	Gene	/|amod|START_ENTITY /|compound|cells cells|compound|END_ENTITY	Intrathyroidal lymphocyte subsets , including unusual CD4 + CD8 + cells and CD3loTCR alpha beta lo / - CD4-CD8 - cells , in autoimmune_thyroid_disease .
8381310	0	CD4	17,20	CD8	22,25	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Double-negative -LRB- CD4 - CD8 - -RRB- T cells from adult_T-cell_leukemia patients also have poor expression of the T-cell_receptor alpha beta/CD3 complex .
8415641	0	CD4	17,20	CD8	21,24	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Precommitment of CD4 + CD8 + thymocytes to either CD4 or CD8 lineages .
8415641	0	CD4	47,50	CD8	21,24	CD4	CD8	920	925	Gene	Gene	lineages|compound|START_ENTITY thymocytes|nmod|lineages thymocytes|nsubj|Precommitment Precommitment|nmod|+ +|compound|END_ENTITY	Precommitment of CD4 + CD8 + thymocytes to either CD4 or CD8 lineages .
8461016	0	CD4	71,74	CD8	76,79	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Cytofluorimetric identification of two populations of double positive -LRB- CD4 + , CD8 + -RRB- T lymphocytes in human peripheral blood .
8556507	0	CD4	155,158	CD8	160,163	CD4	CD8	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD4	155,158	CD8	37,40	CD4	CD8	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY level|nmod|lymphocytes prompted|nmod|level prompted|nsubj|Characterization Characterization|acl|circulating circulating|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD4	32,35	CD8	160,163	CD4	CD8	920	925	Gene	Gene	lymphocytes|nummod|START_ENTITY circulating|dobj|lymphocytes Characterization|acl|circulating prompted|nsubj|Characterization prompted|nmod|level level|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD4	32,35	CD8	37,40	CD4	CD8	920	925	Gene	Gene	lymphocytes|nummod|START_ENTITY lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8630734	0	CD4	39,42	CD8	43,46	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	TCR activation of ZAP70 is impaired in CD4 + CD8 + thymocytes as a consequence of intrathymic interactions that diminish available p56lck .
8634066	0	CD4	84,87	CD8	88,91	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4 + CD8 + thymocytes .
8642767	0	CD4	181,184	CD8	186,189	CD4	CD8	920	925	Gene	Gene	CD3|dep|START_ENTITY CD3|dep|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
8648101	0	CD4	55,58	CD8	59,62	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A role for calcium influx in setting the threshold for CD4 + CD8 + thymocyte negative selection .
8658050	0	CD4	85,88	CD8	90,93	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4 + CD8 + thymocytes .
8679305	0	CD4	100,103	CD8	23,26	CD4	CD8	920	925	Gene	Gene	counts|compound|START_ENTITY individual|nmod|counts activity|nmod|individual activity|compound|END_ENTITY	Delayed virus-specific CD8 + cytotoxic T lymphocyte activity in an HIV-infected individual with high CD4 + cell counts : correlations with various parameters of disease progression .
8697628	0	CD4	101,104	CD8	43,46	CD4	CD8	920	925	Gene	Gene	response|compound|START_ENTITY restimulates|dobj|response immunization|parataxis|restimulates immunization|nmod|humans humans|dep|+ +|compound|END_ENTITY	Peptide immunization in humans : a combined CD8 + / CD4 + T cell-targeted vaccine restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes -LRB- CTL -RRB- .
8697628	0	CD4	48,51	CD8	43,46	CD4	CD8	920	925	Gene	Gene	vaccine|compound|START_ENTITY restimulates|nsubj|vaccine immunization|parataxis|restimulates immunization|nmod|humans humans|dep|+ +|compound|END_ENTITY	Peptide immunization in humans : a combined CD8 + / CD4 + T cell-targeted vaccine restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes -LRB- CTL -RRB- .
8737717	0	CD4	0,3	CD8	46,49	CD4	CD8	920	925	Gene	Gene	cytopenia|compound|START_ENTITY cytopenia|nmod|+ +|compound|END_ENTITY	CD4 cytopenia and occasional expansion of CD4 + CD8 + lymphocytes in Sj gren 's _ syndrome .
8737717	0	CD4	42,45	CD8	46,49	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 cytopenia and occasional expansion of CD4 + CD8 + lymphocytes in Sj gren 's _ syndrome .
8828739	0	CD4	86,89	CD8	38,41	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY decline|nmod|cells predict|dobj|decline predict|nsubj|numbers numbers|nmod|cells cells|compound|END_ENTITY	Increased numbers of primed activated CD8 + CD38 + CD45RO + T cells predict the decline of CD4 + T cells in HIV-1-infected patients .
8889397	0	CD4	28,31	CD8	33,36	CD4	CD8	920	925	Gene	Gene	CD4/CD8|appos|START_ENTITY CD4/CD8|appos|END_ENTITY	Reference intervals of CD3 , CD4 , CD8 , CD4/CD8 , and absolute CD4 values in Asian and Non-Asian populations .
8934573	0	CD4	94,97	CD8	98,101	CD4	CD8	920	925	Gene	Gene	differentiation|compound|START_ENTITY differentiation|compound|END_ENTITY	Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4 + CD8 + thymocyte differentiation .
8958056	0	CD4	63,66	CD8	79,82	CD4	CD8	395362(Tax:9031)	403158(Tax:9031)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|+ +|compound|END_ENTITY	Thymocyte emigration in the chicken : an over-representation of CD4 + cells over CD8 + in the periphery .
8976166	0	CD4	135,138	CD8	92,95	CD4	CD8	920	925	Gene	Gene	synthesis|compound|START_ENTITY terminated|dobj|synthesis terminated|nsubj|commitment commitment|nmod|thymocytes thymocytes|amod|thymus thymus|dep|subset subset|nmod|END_ENTITY	Lineage commitment in the thymus : only the most differentiated -LRB- TCRhibcl-2hi -RRB- subset of CD4 + CD8 + thymocytes has selectively terminated CD4 or CD8 synthesis .
8977176	0	CD4	18,21	CD8	22,25	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TCR engagement of CD4 + CD8 + thymocytes in vitro induces early aspects of positive selection , but not apoptosis .
9016884	0	CD4	191,194	CD8	126,129	CD4	CD8	920	925	Gene	Gene	coreceptor|compound|START_ENTITY biosynthesis|nmod|coreceptor due|nmod|biosynthesis differentiation|amod|due differentiation|nummod|END_ENTITY	Asynchronous coreceptor downregulation after positive thymic selection : prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor .
9022017	0	CD4	19,22	CD8	24,27	CD4	CD8	395362(Tax:9031)	428800(Tax:9031)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9022017	0	CD4	86,89	CD8	24,27	CD4	CD8	395362(Tax:9031)	428800(Tax:9031)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells inheritance|nmod|expression population|dep|inheritance population|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9029083	0	CD4	14,17	CD8	32,35	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY kill|nsubj|cells kill|dobj|cells cells|nummod|END_ENTITY	Cutting edge : CD4 + T cells kill CD8 + T cells via Fas/Fas _ ligand-mediated apoptosis .
9097357	0	CD4	22,25	CD8	26,29	CD4	CD8	920	925	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Invasive_thymoma with CD4 + CD8 + double-positive T cell lymphocytosis .
9100586	0	CD4	154,157	CD8	123,126	CD4	CD8	920	925	Gene	Gene	restriction|compound|START_ENTITY absence|nmod|restriction cells|nmod|absence cells|nummod|END_ENTITY	Analysis of the T cell receptor V alpha repertoire in Hashimoto 's _ thyroiditis : evidence for the restricted accumulation of CD8 + T cells in the absence of CD4 + T cell restriction .
9116306	0	CD4	64,67	CD8	69,72	CD4	CD8	920	925	Gene	Gene	comobilization|nmod|START_ENTITY comobilization|dep|END_ENTITY	Granulocyte_colony-stimulating_factor-induced comobilization of CD4 - CD8 - T cells and hematopoietic progenitor cells -LRB- CD34 + -RRB- in the blood of normal donors .
9174605	0	CD4	56,59	CD8	16,19	CD4	CD8	920	925	Gene	Gene	lineage|compound|START_ENTITY induce|nmod|lineage induce|nsubj|Signals Signals|nmod|END_ENTITY	Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus .
9206998	0	CD4	86,89	CD8	15,18	CD4	CD8	920	925	Gene	Gene	help|compound|START_ENTITY cognate|dobj|help requires|xcomp|cognate requires|nsubj|Induction Induction|nmod|response response|amod|cytotoxic cytotoxic|nmod:npmod|+ +|nummod|END_ENTITY	Induction of a CD8 + cytotoxic T lymphocyte response by cross-priming requires cognate CD4 + T cell help .
9217273	0	CD4	38,41	CD8	43,46	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY 2_vitamin_D3|nmod|+ 1,25|amod|2_vitamin_D3 effect|nmod|1,25 effect|dep|subsets subsets|nummod|END_ENTITY	The effect of 1,25 -LRB- OH -RRB- 2_vitamin_D3 on CD4 + / CD8 + subsets of T lymphocytes in postmenopausal women .
9278294	0	CD4	66,69	CD8	96,99	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells regulated|nsubjpass|activity regulated|nmod|cells cells|compound|END_ENTITY	Perforin-dependent cytotoxic activity and lymphokine secretion by CD4 + T cells are regulated by CD8 + T cells .
9328784	0	CD4	22,25	CD8	26,29	CD4	CD8	920	925	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	The appearance of the CD4 + CD8 + phenotype on activated T cells : possible role of antigen transfer .
9358102	0	CD4	178,181	CD8	36,39	CD4	CD8	920	925	Gene	Gene	count|compound|START_ENTITY marker|nmod|count marker|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	Elevated CD38 antigen expression on CD8 + T cells is a stronger marker for the risk of chronic HIV_disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4 + cell count , soluble immune activation markers , or combinations of HLA-DR and CD38 expression .
9366400	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	CD4 + CD8 + thymocytes are preferentially induced to die following CD45 cross-linking , through a novel apoptotic pathway .
9382889	0	CD4	48,51	CD8	52,55	CD4	CD8	920	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	T cell receptor -LRB- TCR -RRB- - induced death of immature CD4 + CD8 + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation : implications for negative selection in the thymus .
9390138	0	CD4	28,31	CD8	33,36	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY ratio|nmod|+ Correlation|nmod|ratio Correlation|dep|cells cells|nummod|END_ENTITY	Correlation of the ratio of CD4 + / CD8 + cells in lymph_node fine needle aspiration biopsies with HIV clinical status .
9413259	0	CD4	113,116	CD8	6,9	CD4	CD8	920	925	Gene	Gene	T-cells|compound|START_ENTITY autoreactive|dobj|T-cells modulate|ccomp|autoreactive modulate|nsubj|beta beta|compound|END_ENTITY	Human CD8 + TCR-alpha beta -LRB- + -RRB- and TCR-gamma delta -LRB- + -RRB- cells modulate autologous autoreactive neuroantigen-specific CD4 + T-cells by different mechanisms .
9445068	0	CD4	38,41	CD8	157,160	CD4	CD8	920	925	Gene	Gene	lines|compound|START_ENTITY lines|dep|system system|nmod|analysis analysis|nmod|activity activity|compound|END_ENTITY	Herpesvirus_saimiri-transformed human CD4 + T-cell lines : an efficient target cell system for the analysis of human immunodeficiency virus-specific cytotoxic CD8 + T-lymphocyte activity .
9486410	0	CD4	12,15	CD8	16,19	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Circulating CD4 + CD8 + T lymphocytes in patients with Kawasaki_disease .
9499792	0	CD4	21,24	CD8	101,104	CD4	CD8	920	925	Gene	Gene	lymphocytes|nummod|START_ENTITY killing|nmod|lymphocytes mediated|nsubjpass|killing mediated|nmod|cells cells|compound|END_ENTITY	Apoptotic killing of CD4 + T lymphocytes in HIV-1-infected PHA-stimulated PBL cultures is mediated by CD8 + LAK cells .
9516566	0	CD4	63,66	CD8	68,71	CD4	CD8	920	925	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Changes in peripheral blood double-negative T-lymphocyte -LRB- CD3 + CD4 - CD8 - -RRB- populations associated with acute cellular rejection after liver transplantation .
9551888	1	CD4	148,151	CD8	72,75	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells induce|dobj|apoptosis induce|nsubj|cells cells|compound|END_ENTITY	I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells .
9552002	0	CD4	54,57	CD8	0,3	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY chemoattract|dobj|+ myelin|ccomp|chemoattract cells|amod|myelin cells|nummod|END_ENTITY	CD8 + myelin peptide-specific T cells can chemoattract CD4 + myelin peptide-specific T cells : importance of IFN-inducible protein 10 .
9558078	0	CD4	27,30	CD8	33,36	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|appos|cell cell|compound|END_ENTITY	Differential capacities of CD4 + , CD8 + , and CD4-CD8 - T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18 .
9573253	0	CD4	58,61	CD8	62,65	CD4	CD8	920	925	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Vaccine-induced , pseudorabies_virus-specific , extrathymic CD4 + CD8 + memory T-helper cells in swine .
9596673	0	CD4	64,67	CD8	69,72	CD4	CD8	920	925	Gene	Gene	thymocytes|nummod|START_ENTITY thymocytes|compound|END_ENTITY	Viral superantigen-induced negative selection of TCR transgenic CD4 + CD8 + thymocytes depends on activation , but not proliferation .
9603183	0	CD4	76,79	CD8	13,16	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells generation|dep|function generation|compound|END_ENTITY	Xenospecific CD8 + cytotoxic T lymphocyte generation : accessory function for CD4 + T cells and natural killer 1.1 + cells .
9649210	0	CD4	102,105	CD8	106,109	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Neoplastic thymic epithelial cells of human thymoma support T cell development from CD4-CD8 - cells to CD4 + CD8 + cells in vitro .
9681236	0	CD4	52,55	CD8	57,60	CD4	CD8	920	925	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Severe bactrim-induced neutropenia with reversal of CD4 + / CD8 + lymphocyte ratio : response to recombinant human granulocyte-colony_stimulating_factor -LRB- R-metHUG-CSF -RRB- .
9765450	0	CD4	50,53	CD8	23,26	CD4	CD8	920	925	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|Costimulation Costimulation|nmod|lymphocytes lymphocytes|amod|naive naive|dep|END_ENTITY	Costimulation of naive CD8 -LRB- + -RRB- lymphocytes induces CD4 expression and allows human_immunodeficiency_virus_type_1_infection .
9773872	0	CD4	110,113	CD8	54,57	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY expression|nmod|T using|dobj|expression expression|acl|using expression|nmod|cells cells|nummod|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9773872	0	CD4	92,95	CD8	54,57	CD4	CD8	920	925	Gene	Gene	expression|nummod|START_ENTITY using|dobj|expression expression|acl|using expression|nmod|cells cells|nummod|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9806050	0	CD4	94,97	CD8	98,101	CD4	CD8	920	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Persistent expansion , in a human_immunodeficiency_virus-infected person , of V beta-restricted CD4 + CD8 + T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha .
9820490	0	CD4	30,33	CD8	76,79	CD4	CD8	920	925	Gene	Gene	suppression|nmod|START_ENTITY +|nsubj|suppression +|nmod|CD28 CD28|compound|END_ENTITY	Specific suppression of human CD4 + Th cell responses to pig MHC antigens by CD8 + CD28 - regulatory T cells .
9855049	0	CD4	0,3	CD8	5,8	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD8 + and CD8alpha + beta - T lymphocytes in human small intestinal lamina propria .
9862094	0	CD4	0,3	CD8	60,63	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY orchestrate|nsubj|cells orchestrate|dobj|amplification amplification|nmod|cells cells|compound|END_ENTITY	CD4 + T cells orchestrate both amplification and deletion of CD8 + T cells .
9885901	0	CD4	93,96	CD8	97,100	CD4	CD8	920	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4 + CD8 + thymocytes .
9892683	0	CD4	108,111	CD8	114,117	CD4	CD8	920	925	Gene	Gene	thymocytes|amod|START_ENTITY thymocytes|amod|END_ENTITY	Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes .
9933085	0	CD4	83,86	CD8	63,66	CD4	CD8	920	925	Gene	Gene	cells|compound|START_ENTITY costimulated|nsubjpass|cells provide|advcl|costimulated provide|nmod|cells cells|compound|END_ENTITY	ICAM-1_and_B7-1 provide similar but distinct costimulation for CD8 + T cells , while CD4 + T cells are poorly costimulated by ICAM-1 .
11955430	0	CD4	27,30	CD83	0,4	CD4	CD83	12504(Tax:10090)	12522(Tax:10090)	Gene	Gene	development|compound|START_ENTITY influences|dobj|development influences|nsubj|expression expression|compound|END_ENTITY	CD83 expression influences CD4 + T cell development in the thymus .
15322158	0	CD4	78,81	CD83	20,24	CD4	CD83	12504(Tax:10090)	12522(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY population|nmod|cells development|nmod|population results|nmod|development results|nsubj|mutation mutation|nmod|END_ENTITY	A novel mutation in CD83 results in the development of a unique population of CD4 + T cells .
18424708	0	CD4	19,22	CD83	0,4	CD4	CD83	12504(Tax:10090)	12522(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD83 expression in CD4 + T cells modulates inflammation and autoimmunity .
25997495	0	CD4	49,52	CD83	25,29	CD4	CD83	920	9308	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Continuous expression of CD83 on activated human CD4 + T cells is correlated with their differentiation into induced regulatory T cells .
15356107	0	CD4	49,52	CD86	6,10	CD4	CD86	12504(Tax:10090)	12524(Tax:10090)	Gene	Gene	response|compound|START_ENTITY priming|nmod|response controls|dobj|priming controls|nsubj|B7-2 B7-2|appos|END_ENTITY	B7-2 -LRB- CD86 -RRB- controls the priming of autoreactive CD4 T cell response against pancreatic islets .
15788440	0	CD4	46,49	CD86	11,15	CD4	CD86	12504(Tax:10090)	12524(Tax:10090)	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	CTLA4-CD80 / CD86 interactions on primary mouse CD4 + T cells integrate signal-strength information to modulate activation with Concanavalin_A .
16339520	0	CD4	119,122	CD86	39,43	CD4	CD86	920	942	Gene	Gene	cells|compound|START_ENTITY polarization|nmod|cells induces|dobj|polarization induces|nsubj|Ligation Ligation|nmod|CD28 CD28|nmod|END_ENTITY	Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells .
22246628	0	CD4	42,45	CD86	17,21	CD4	CD86	920	942	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	IL-2 upregulates CD86 expression on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
8952962	0	CD4	84,87	CD8A	65,69	CD4	CD8A	920	925	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Post-transcriptional regulation associated with control of human CD8A expression of CD4 + T cells .
10553054	0	CD4	30,33	CD8_alpha	12,21	CD4	CD8 alpha	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of CD8_alpha ' in the CD4 versus CD8 lineage choice .
1460418	0	CD4	90,93	CD8_alpha	41,50	CD4	CD8 alpha	24932(Tax:10116)	24930(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY chains|nmod|cells chains|amod|END_ENTITY	Glucocorticoids induce the expression of CD8_alpha chains on concanavalin A-activated rat CD4 + T cells : induction is inhibited by rat recombinant interleukin_4 .
15114659	0	CD4	61,64	CD8_alpha	0,9	CD4	CD8 alpha	24932(Tax:10116)	24930(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells marker|nmod|subset marker|nsubj|END_ENTITY	CD8_alpha is an activation marker for a subset of peripheral CD4 T cells .
7614985	0	CD4	30,33	CD8_alpha	17,26	CD4	CD8 alpha	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Co-expression of CD8_alpha in CD4 + T cell receptor alpha beta + T cells migrating into the murine small intestine epithelial layer .
7876540	1	CD4	142,145	CD8_alpha	181,190	CD4	CD8 alpha	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY mature|dobj|cells Evidence|acl:relcl|mature induced|nsubjpass|Evidence induced|xcomp|express express|dobj|END_ENTITY	Evidence that mature post-thymic CD4 + T cells can be induced to express CD8_alpha in vivo .
8426123	0	CD4	82,85	CD8_alpha	172,181	CD4	CD8 alpha	24932(Tax:10116)	24930(Tax:10116)	Gene	Gene	,8|compound|START_ENTITY thymocytes|nummod|,8 rat|dep|thymocytes rat|acl|initiating initiating|dobj|pathway pathway|nmod|T T|compound|END_ENTITY	T cell receptor ligation induces interleukin -LRB- IL -RRB- 2R beta chain expression in rat CD4 ,8 double positive thymocytes , initiating an IL-2-dependent differentiation pathway of CD8_alpha + / beta - T cells .
9551905	0	CD4	38,41	CD8_alpha	154,163	CD4	CD8 alpha	12504(Tax:10090)	24930(Tax:10116)	Gene	Gene	+8|compound|START_ENTITY mouse|nummod|+8 decisions|nmod|mouse lineage|dobj|decisions lineage|nmod|signals signals|dep|correlation correlation|nmod|expression expression|nmod|chain chain|amod|END_ENTITY	Opposite CD4/CD8 lineage decisions of CD4 +8 + mouse and rat thymocytes to equivalent triggering signals : correlation with thymic expression of a truncated CD8_alpha chain in mice but not rats .
22066016	0	CD4	16,19	CD8a	30,34	CD4	CD8a	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Spleen-resident CD4 + and CD4 - CD8a - dendritic cell subsets differ in their ability to prime invariant natural killer T lymphocytes .
23738014	0	CD4	126,129	CD8a	25,29	CD4	CD8a	920	925	Gene	Gene	T|compound|START_ENTITY functions|nmod|T restricted|dobj|functions I|acl|restricted sufficient|nmod|I cells|amod|sufficient cells|nsubj|domains domains|nmod|END_ENTITY	Extracellular domains of CD8a and CD8 subunits are sufficient for HLA class I restricted helper functions of TCR-engineered CD4 -LRB- + -RRB- T cells .
10560824	0	CD4	28,31	CD8alpha	97,105	CD4	CD8alpha	100126554(Tax:9103)	100126556(Tax:9103)	Gene	Gene	suggest|nsubj|START_ENTITY suggest|dobj|polymorphism polymorphism|nmod|molecule molecule|compound|END_ENTITY	Cross-reactive anti-chicken CD4 and CD8 monoclonal antibodies suggest polymorphism of the turkey CD8alpha molecule .
11001905	0	CD4	138,141	CD8alpha	75,83	CD4	CD8alpha	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	generated|advcl|START_ENTITY generated|nsubjpass|cells cells|amod|revisited revisited|dep|END_ENTITY	Concept of lymphoid versus myeloid dendritic cell lineages revisited : both CD8alpha -LRB- - -RRB- and CD8alpha -LRB- + -RRB- dendritic cells are generated from CD4 -LRB- low -RRB- lymphoid-committed precursors .
14607905	0	CD4	73,76	CD8alpha	0,8	CD4	CD8alpha	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY controls|dobj|immunity controls|nsubj|+ +|compound|END_ENTITY	CD8alpha + and CD11b + dendritic cell-restricted MHC class II controls Th1 CD4 + T cell immunity .
15496961	0	CD4	18,21	CD8alpha	132,140	CD4	CD8alpha	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY Redirecting|dobj|lymphocytes requires|dep|Redirecting requires|dobj|END_ENTITY	Redirecting human CD4 + T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha .
16836648	0	CD4	71,74	CD8alpha	14,22	CD4	CD8alpha	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY subset|nmod|lymphocytes identifies|dobj|subset identifies|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD8alpha identifies a distinct subset of effector memory CD4 + T lymphocytes .
17313653	2	CD4	172,175	CD8alpha	115,123	CD4	CD8alpha	920	925	Gene	Gene	lymphocytes|compound|START_ENTITY subset|nmod|lymphocytes identifies|dobj|subset identifies|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD8alpha identifies a distinct subset of effector memory CD4 T lymphocytes .
17610959	0	CD4	55,58	CD8alpha	0,8	CD4	CD8alpha	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	response|compound|START_ENTITY enhance|dobj|response +|ccomp|enhance +|nsubj|END_ENTITY	CD8alpha + dendritic cells enhance the antigen-specific CD4 + T-cell response and accelerate development of collagen-induced_arthritis .
20394075	0	CD4	64,67	CD8alpha	0,8	CD4	CD8alpha	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	FOXP3|compound|START_ENTITY cells|dep|FOXP3 cells|nummod|+ +|compound|END_ENTITY	CD8alpha + dendritic cells prime TCR-peptide-reactive regulatory CD4 + FOXP3 - T cells .
9022017	0	CD4	19,22	CD8alpha	63,71	CD4	CD8alpha	395362(Tax:9031)	428800(Tax:9031)	Gene	Gene	population|compound|START_ENTITY population|dep|inheritance inheritance|nmod|expression expression|amod|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9022017	0	CD4	86,89	CD8alpha	63,71	CD4	CD8alpha	395362(Tax:9031)	428800(Tax:9031)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9139839	0	CD4	30,33	CD8alpha	35,43	CD4	CD8alpha	920	925	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of an enriched CD4 + CD8alpha + + CD8beta + T-cell subset among tumor-infiltrating lymphocytes in human renal_cell_carcinoma .
21821134	0	CD4	25,28	CD8b	30,34	CD4	CD8b	100169855(Tax:8030)	100136451(Tax:8030)	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of CD3 , CD4 , CD8b splice variants of Atlantic_salmon .
10552959	0	CD4	75,78	CD8beta	47,54	CD4	CD8beta	920	926	Gene	Gene	CD8alphaalpha|compound|START_ENTITY expression|nmod|CD8alphaalpha expression|amod|END_ENTITY	Beta-selection is associated with the onset of CD8beta chain expression on CD4 -LRB- + -RRB- CD8alphaalpha -LRB- + -RRB- pre-T cells during human intrathymic development .
9139839	0	CD4	30,33	CD8beta	46,53	CD4	CD8beta	920	926	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of an enriched CD4 + CD8alpha + + CD8beta + T-cell subset among tumor-infiltrating lymphocytes in human renal_cell_carcinoma .
10505674	0	CD4	119,122	CD95	148,152	CD4	CD95	920	355	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	The cell death-inducing ability of glycoprotein 120 from different HIV strains correlates with their ability to induce CD4 lateral association with CD95 on CD4 + T cells .
10505674	0	CD4	156,159	CD95	148,152	CD4	CD95	920	355	Gene	Gene	cells|compound|START_ENTITY induce|nmod|cells induce|dobj|association association|nmod|END_ENTITY	The cell death-inducing ability of glycoprotein 120 from different HIV strains correlates with their ability to induce CD4 lateral association with CD95 on CD4 + T cells .
11122022	0	CD4	61,64	CD95	35,39	CD4	CD95	920	355	Gene	Gene	T|compound|START_ENTITY Fas|nmod|T Fas|appos|END_ENTITY	Decreased expression of Fas -LRB- APO-1 / CD95 -RRB- on peripheral blood CD4 + T lymphocytes in cutaneous_T-cell_lymphomas .
11122244	0	CD4	126,129	CD95	13,17	CD4	CD95	920	355	Gene	Gene	lymphocytes|compound|START_ENTITY apoptosis|nmod|lymphocytes ligand|nmod|apoptosis ligand|nsubj|Induction Induction|nmod|END_ENTITY	Induction of CD95 ligand expression on T lymphocytes and B lymphocytes and its contribution to apoptosis of CD95-up-regulated CD4 + T lymphocytes in macaques by infection with a pathogenic simian/human _ immunodeficiency_virus .
11134499	0	CD4	37,40	CD95	0,4	CD4	CD95	920	355	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|amod|END_ENTITY	CD95 -LRB- APO-1 / Fas -RRB- expression on naive CD4 -LRB- + -RRB- T cells increases with disease progression in HIV-infected children and adolescents : effect of highly active antiretroviral therapy -LRB- HAART -RRB- .
11272277	0	CD4	53,56	CD95	120,124	CD4	CD95	920	355	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|nmod|up-regulation up-regulation|nmod|Fas Fas|appos|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
11279310	0	CD4	45,48	CD95	36,40	CD4	CD95	920	355	Gene	Gene	+|compound|START_ENTITY Fas|nmod|+ Fas|appos|APO-1 APO-1|dep|END_ENTITY	Increased expression of Fas -LRB- APO-1 , CD95 -RRB- on CD4 + and CD8 + T lymphocytes during total_body_irradiation .
11859105	0	CD4	65,68	CD95	89,93	CD4	CD95	12504(Tax:10090)	14102(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generates|dobj|cells generates|xcomp|expressing expressing|dobj|IL-4 IL-4|compound|END_ENTITY	Administration of an antigen at a high dose generates regulatory CD4 + T cells expressing CD95 ligand and secreting IL-4 in the liver .
14739941	0	CD4	143,146	CD95	91,95	CD4	CD95	920	355	Gene	Gene	T|compound|START_ENTITY apoptosis|nmod|T lymphocytes|nsubj|apoptosis mediated|ccomp|lymphocytes mediated|nsubj|-2 -2|acl|induced induced|nmod|END_ENTITY	CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL -2 - induced susceptibility to CD95 -LRB- APO-1 / Fas -RRB- - mediated apoptosis of human resting CD4 -LRB- + -RRB- T lymphocytes .
15972628	0	CD4	33,36	CD95	94,98	CD4	CD95	920	355	Gene	Gene	FoxP3|compound|START_ENTITY +|nsubj|FoxP3 +|ccomp|susceptible susceptible|nmod|END_ENTITY	In contrast to effector T cells , CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand - but not to TCR-mediated cell death .
16767155	0	CD4	60,63	CD95	0,4	CD4	CD95	920	355	Gene	Gene	thymic_lymphoma|compound|START_ENTITY apoptosis|nmod|thymic_lymphoma ligand|dobj|apoptosis ligand|nsubj|END_ENTITY	CD95 ligand mediates T-cell_receptor-induced apoptosis of a CD4 + CD8 + double positive thymic_lymphoma .
18855225	0	CD4	48,51	CD95	32,36	CD4	CD95	920	355	Gene	Gene	lymphocytes|nummod|START_ENTITY Fas|nmod|lymphocytes Fas|dobj|levels levels|appos|END_ENTITY	Increased surface receptor Fas -LRB- CD95 -RRB- levels on CD4 + lymphocytes in patients with primary_intestinal_lymphangiectasia .
20181888	0	CD4	19,22	CD95	93,97	CD4	CD95	920	355	Gene	Gene	cells|nummod|START_ENTITY protects|dobj|cells protects|advcl|blocking blocking|dobj|upregulation upregulation|compound|END_ENTITY	Melatonin protects CD4 + T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation .
21052094	0	CD4	14,17	CD95	40,44	CD4	CD95	920	355	Gene	Gene	T-cell|compound|START_ENTITY Modulation|nmod|T-cell activation|nsubj|Modulation activation|nmod|co-stimulation co-stimulation|compound|END_ENTITY	Modulation of CD4 + T-cell activation by CD95 co-stimulation .
25411246	0	CD4	43,46	CD95	27,31	CD4	CD95	920	355	Gene	Gene	Cells|compound|START_ENTITY Protein|nmod|Cells Protein|compound|END_ENTITY	Interleukin 7 Up-regulates CD95 Protein on CD4 + T Cells by Affecting mRNA Alternative Splicing : PRIMING FOR A SYNERGISTIC EFFECT ON HIV-1 RESERVOIR MAINTENANCE .
26858545	0	CD4	52,55	CD95	12,16	CD4	CD95	920	355	Gene	Gene	lymphocytes|amod|START_ENTITY circulating|dobj|lymphocytes expression|acl|circulating expression|compound|END_ENTITY	Analysis of CD95 and CCR7 expression on circulating CD4 -LRB- + -RRB- lymphocytes revealed disparate immunoregulatory potentials in systemic_lupus_erythematosus .
7589104	0	CD4	71,74	CD95	122,126	CD4	CD95	12504(Tax:10090)	14102(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY deletion|nmod|CD8 deletion|nmod|_ _|compound|END_ENTITY	Clonal deletion of major histocompatibility complex class I-restricted CD4 + CD8 + thymocytes in vitro is independent of the CD95 -LRB- APO-1 / Fas -RRB- _ ligand .
8855300	0	CD4	66,69	CD95	5,9	CD4	CD95	920	355	Gene	Gene	cross-linking|nummod|START_ENTITY induced|nmod|cross-linking induced|nsubjpass|expression expression|compound|END_ENTITY	Fas -LRB- CD95 -RRB- expression and death-mediating function are induced by CD4 cross-linking on CD4 + T cells .
8855300	0	CD4	87,90	CD95	5,9	CD4	CD95	920	355	Gene	Gene	cells|compound|START_ENTITY cross-linking|nmod|cells induced|nmod|cross-linking induced|nsubjpass|expression expression|compound|END_ENTITY	Fas -LRB- CD95 -RRB- expression and death-mediating function are induced by CD4 cross-linking on CD4 + T cells .
9083895	0	CD4	102,105	CD95	106,110	CD4	CD95	920	355	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8 + CD95 + , CD8 + CD38 + , and CD4 + CD95 + T cells are markers for HIV-1_infection and clinical status .
9455798	0	CD4	0,3	CD95	75,79	CD4	CD95	920	355	Gene	Gene	cells|compound|START_ENTITY kill|nsubj|cells kill|nmod|mechanisms mechanisms|appos|END_ENTITY	CD4 T cells kill melanoma cells by mechanisms that are independent of Fas -LRB- CD95 -RRB- .
9596676	0	CD4	28,31	CD95	94,98	CD4	CD95	920	355	Gene	Gene	+|compound|START_ENTITY sensitivity|nmod|+ lymphocytes|nsubj|sensitivity lymphocytes|nmod|efficacy efficacy|nmod|cells cells|appos|END_ENTITY	Differential sensitivity of CD4 + and CD8 + T lymphocytes to the killing efficacy of Fas -LRB- Apo-1 / CD95 -RRB- ligand + tumor cells in B chronic_lymphocytic_leukemia .
11272277	0	CD4	53,56	CD95L	138,143	CD4	CD95L	920	356	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|nmod|up-regulation up-regulation|nmod|Fas Fas|appos|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
8497074	0	CD4	45,48	CDR-3	29,34	CD4	CDR-3	920	8163	Gene	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	A monoclonal antibody to the CDR-3 region of CD4 inhibits soluble CD4 binding to virions of human_immunodeficiency_virus_type_1 .
11916170	0	CD4	24,27	CDR3	6,10	CD4	CDR3	920	8163	Gene	Gene	+|compound|START_ENTITY diversity|nmod|+ diversity|compound|END_ENTITY	TCRBV CDR3 diversity of CD4 + and CD8 + T-lymphocytes in HIV-infected individuals .
18248531	0	CD4	38,41	CD_127	0,6	CD4	CD 127	920	3575	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	CD_127 - and FoxP3 + expression on CD25 + CD4 + T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type_1_diabetes_mellitus patients .
23252864	0	CD4	16,19	CD_25	20,25	CD4	CD 25	920	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Crucial role of CD4 + CD_25 + FOXP3 + T regulatory cell , interferon-y and interleukin-16 in malignant and tuberculous_pleural_effusions .
11564186	0	CD4	162,165	CLA	131,134	CD4	CLA	920	6404	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nmod|END_ENTITY	Development and characterization of a monoclonal antibody specific for fucosyltransferase_VII -LRB- Fuc-TVII -RRB- : discordant expression of CLA and Fuc-TVII in peripheral CD4 + and CD8 + T cells .
14705795	0	CD4	7,10	CLA	120,123	CD4	CLA	920	6404	Gene	Gene	cells|compound|START_ENTITY show|nsubj|cells show|dobj|cells cells|compound|END_ENTITY	Na ve CD4 + T cells from patients with atopic_dermatitis show an aberrant maturation towards IL-4-producing skin-homing CLA + cells .
15270870	0	CD4	30,33	CLA	35,38	CD4	CLA	920	6404	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Nickel-responding T cells are CD4 + CLA + CD45RO + and express chemokine receptors CXCR3 , CCR4 and CCR10 .
16197392	0	CD4	47,50	CLA	42,45	CD4	CLA	920	6404	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Absence of CD26 expression on skin-homing CLA + CD4 + T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with S __ zary_syndrome .
17222460	0	CD4	120,123	CLA	112,115	CD4	CLA	920	6404	Gene	Gene	START_ENTITY|amod|reactivity reactivity|nmod|constructs constructs|nmod|antigen antigen|appos|END_ENTITY	Varied levels of reactivity by different E-selectin/Fc constructs with cutaneous lymphocyte-associated antigen -LRB- CLA -RRB- -LRB- + -RRB- CD4 -LRB- + -RRB- T cells .
1839374	0	CD4	84,87	CR1	120,123	CD4	CR1	920	1378	Gene	Gene	cells|amod|START_ENTITY cells|amod|express express|dep|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression on peripheral T lymphocytes : both CD4 - and CD8-positive cells express CR1 .
1839374	0	CD4	84,87	CR1	28,31	CD4	CR1	920	1378	Gene	Gene	cells|amod|START_ENTITY expression|dep|cells expression|appos|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression on peripheral T lymphocytes : both CD4 - and CD8-positive cells express CR1 .
7682158	0	CD4	141,144	CR1	0,3	CD4	CR1	920	1378	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	CR1 -LRB- CD35 -RRB- and CR3 -LRB- CD11b/CD18 -RRB- mediate infection of human monocytes and monocytic cell lines with complement-opsonized HIV independently of CD4 .
8918576	0	CD4	40,43	CR1	12,15	CD4	CR1	920	1378	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	Ligation of CR1 -LRB- C3b receptor , CD35 -RRB- on CD4 + T lymphocytes enhances viral replication in HIV-infected cells .
17067313	0	CD4	148,151	CRTH2	107,112	CD4	CRTH2	920	11251	Gene	Gene	Th2|compound|START_ENTITY chemotaxis|nmod|Th2 cells|nmod|chemotaxis cells|appos|END_ENTITY	A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 -LRB- Th2 -RRB- cells -LRB- CRTH2 -RRB- in mediating chemotaxis of CRTH2 + CD4 + Th2 lymphocytes in response to mast cell supernatants .
17067313	0	CD4	148,151	CRTH2	141,146	CD4	CRTH2	920	11251	Gene	Gene	Th2|compound|START_ENTITY Th2|compound|END_ENTITY	A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 -LRB- Th2 -RRB- cells -LRB- CRTH2 -RRB- in mediating chemotaxis of CRTH2 + CD4 + Th2 lymphocytes in response to mast cell supernatants .
17437532	0	CD4	155,158	CRTH2	102,107	CD4	CRTH2	920	11251	Gene	Gene	T|compound|START_ENTITY activation|nmod|T mediating|dobj|activation role|acl|mediating role|appos|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
17437532	0	CD4	155,158	CRTH2	148,153	CD4	CRTH2	920	11251	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
1976737	0	CD4	29,32	CS1	60,63	CD4	CS1	920	1442	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	VLA-4 mediates CD3-dependent CD4 + T cell activation via the CS1 alternatively spliced domain of fibronectin .
10190907	0	CD4	152,155	CTLA-4	45,51	CD4	CTLA-4	920	1493	Gene	Gene	T|compound|START_ENTITY independently|nmod|T activation|advmod|independently regulate|dobj|activation regulate|nsubj|antigen antigen|appos|END_ENTITY	Cytotoxic T lymphocyte-associated antigen 4 -LRB- CTLA-4 -RRB- can regulate dendritic cell-induced activation and cytotoxicity of CD8 -LRB- + -RRB- T cells independently of CD4 -LRB- + -RRB- T cell help .
10411922	0	CD4	91,94	CTLA-4	34,40	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY regulates|ccomp|T regulates|nsubj|Cytotoxic_T_lymphocyte_antigen-4 Cytotoxic_T_lymphocyte_antigen-4|appos|END_ENTITY	Cytotoxic_T_lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- regulates primary and secondary peptide-specific CD4 -LRB- + -RRB- T cell responses .
10549630	0	CD4	61,64	CTLA-4	0,6	CD4	CTLA-4	920	1493	Gene	Gene	cell|compound|START_ENTITY reverses|nmod|cell reverses|nsubj|blockade blockade|compound|END_ENTITY	CTLA-4 blockade reverses CD8 + T cell tolerance to tumor by a CD4 + T cell - and IL-2-dependent mechanism .
10632663	0	CD4	30,33	CTLA-4	9,15	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Elevated CTLA-4 expression on CD4 T cells from periodontitis patients stimulated with Porphyromonas_gingivalis outer membrane antigen .
10725710	0	CD4	22,25	CTLA-4	60,66	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	Polarization|nmod|START_ENTITY +|nsubj|Polarization +|nmod|costimulation costimulation|compound|END_ENTITY	Polarization of naive CD4 + T cells toward the Th1 subset by CTLA-4 costimulation .
10744647	0	CD4	11,14	CTLA-4	69,75	CD4	CTLA-4	920	1493	Gene	Gene	fate|compound|START_ENTITY fate|nmod|re-stimulation re-stimulation|nmod|END_ENTITY	Control of CD4 T cell fate by antigen re-stimulation with or without CTLA-4 engagement 24 h after priming .
10882627	0	CD4	0,3	CTLA-4	76,82	CD4	CTLA-4	920	1493	Gene	Gene	lymphocytes|compound|START_ENTITY express|nsubj|lymphocytes express|dobj|levels levels|nmod|END_ENTITY	CD4 alphabeta T lymphocytes express high levels of the T lymphocyte antigen CTLA-4 -LRB- CD152 -RRB- in acute_malaria .
11050166	0	CD4	107,110	CTLA-4	34,40	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY pool|nmod|cells size|nmod|pool regulates|dobj|size regulates|nsubj|Cytotoxic_T_lymphocyte_antigen-4 Cytotoxic_T_lymphocyte_antigen-4|appos|END_ENTITY	Cytotoxic_T_lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- regulates the size , reactivity , and function of a primed pool of CD4 + T cells .
11801641	0	CD4	5,8	CTLA-4	54,60	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|immunoregulation immunoregulation|amod|END_ENTITY	CD25 + CD4 + regulatory T cells prevent graft rejection : CTLA-4 - and IL-10-dependent immunoregulation of alloresponses .
11970985	0	CD4	58,61	CTLA-4	0,6	CD4	CTLA-4	920	1493	Gene	Gene	signaling|nmod|START_ENTITY proximal|dep|signaling proximal|nsubj|suppresses suppresses|compound|END_ENTITY	CTLA-4 suppresses proximal TCR signaling in resting human CD4 -LRB- + -RRB- T cells by inhibiting ZAP-70 Tyr -LRB- 319 -RRB- phosphorylation : a potential role for tyrosine phosphatases .
12244135	0	CD4	159,162	CTLA-4	14,20	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY kinases|nmod|cells regulates|dobj|kinases regulates|nsubj|END_ENTITY	Cutting edge : CTLA-4 -LRB- CD152 -RRB- differentially regulates mitogen-activated protein kinases -LRB- extracellular_signal-regulated_kinase and c-Jun_N-terminal_kinase -RRB- in CD4 + T cells from receptor/ligand-deficient mice .
12444128	0	CD4	93,96	CTLA-4	60,66	CD4	CTLA-4	920	1493	Gene	Gene	T|compound|START_ENTITY up-regulation|nmod|T up-regulation|appos|END_ENTITY	Cyclic_adenosine_5 ' - monophosphate and calcium induce CD152 -LRB- CTLA-4 -RRB- up-regulation in resting CD4 + T lymphocytes .
15295006	0	CD4	35,38	CTLA-4	9,15	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|dobj|cells induces|nsubj|engagement engagement|compound|END_ENTITY	Targeted CTLA-4 engagement induces CD4 + CD25 + CTLA-4high T regulatory cells with target -LRB- allo -RRB- antigen specificity .
15468055	0	CD4	41,44	CTLA-4	18,24	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	function|compound|START_ENTITY roles|nmod|function roles|nmod|END_ENTITY	Distinct roles of CTLA-4 and TGF-beta in CD4 + CD25 + regulatory T cell function .
15484187	0	CD4	32,35	CTLA-4	78,84	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY properties|nmod|cells dependent|nsubj|properties dependent|nmod|expression expression|compound|END_ENTITY	Suppressive properties of human CD4 + CD25 + regulatory T cells are dependent on CTLA-4 expression .
15585846	0	CD4	37,40	CTLA-4	0,6	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	proliferation|compound|START_ENTITY acts|nmod|proliferation acts|nsubj|engagement engagement|compound|END_ENTITY	CTLA-4 engagement acts as a brake on CD4 + T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance .
16221546	0	CD4	68,71	CTLA-4	40,46	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY eicosapentaenoic_acid|nmod|T-cells eicosapentaenoic_acid|dobj|expression expression|compound|END_ENTITY	Dietary eicosapentaenoic_acid modulates CTLA-4 expression in murine CD4 + T-cells .
16882704	0	CD4	68,71	CTLA-4	0,6	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY T-cell|nsubj|dysregulation dysregulation|compound|END_ENTITY	CTLA-4 dysregulation of self/tumor-reactive CD8 + T-cell function is CD4 + T-cell dependent .
16887994	0	CD4	33,36	CTLA-4	69,75	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells facilitated|nsubjpass|suppression facilitated|nmod|signaling signaling|compound|END_ENTITY	TGF-beta-mediated suppression by CD4 + CD25 + T cells is facilitated by CTLA-4 signaling .
16982872	0	CD4	22,25	CTLA-4	12,18	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Blockade of CTLA-4 on CD4 + CD25 + regulatory T cells abrogates their function in vivo .
17015751	0	CD4	62,65	CTLA-4	97,103	CD4	CTLA-4	920	1493	Gene	Gene	patients|nmod|START_ENTITY suppressors|nmod|patients Induction|nmod|suppressors +|nsubj|Induction +|nmod|signaling signaling|compound|END_ENTITY	Induction of IL-10 suppressors in lung transplant patients by CD4 +25 + regulatory T cells through CTLA-4 signaling .
17404100	0	CD4	67,70	CTLA-4	9,15	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	compartment|compound|START_ENTITY ameliorates|nmod|compartment ameliorates|nsubj|blockade blockade|compound|END_ENTITY	Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4 + T cell compartment without affecting regulatory T-cell function .
17906628	0	CD4	39,42	CTLA-4	16,22	CD4	CTLA-4	920	1493	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Upregulation of CTLA-4 by HIV-specific CD4 + T cells correlates with disease progression and defines a reversible immune_dysfunction .
17911604	0	CD4	55,58	CTLA-4	23,29	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induces|dobj|+ induces|nsubj|engagement engagement|nmod|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18272926	0	CD4	27,30	CTLA-4	0,6	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY converts|dobj|CD25 converts|nsubj|Ig Ig|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CD4	50,53	CTLA-4	0,6	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells converts|dobj|CD25 converts|nsubj|Ig Ig|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18397268	0	CD4	73,76	CTLA-4	63,69	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4 + CD25 + T cells .
18641304	0	CD4	55,58	CTLA-4	111,117	CD4	CTLA-4	920	1493	Gene	Gene	CD25|compound|START_ENTITY function|nmod|CD25 function|parataxis|associated associated|nmod|expression expression|nmod|END_ENTITY	Acquisition of suppressive function by activated human CD4 + CD25 - T cells is associated with the expression of CTLA-4 not FoxP3 .
18818309	0	CD4	45,48	CTLA-4	0,6	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY increases|dobj|cells increases|nsubj|blockade blockade|compound|END_ENTITY	CTLA-4 blockade increases IFNgamma-producing CD4 + ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients .
19179471	0	CD4	23,26	CTLA-4	0,6	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance .
19188497	0	CD4	0,3	CTLA-4	32,38	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY require|nsubj|cells require|dobj|END_ENTITY	CD4 + regulatory T cells require CTLA-4 for the maintenance of systemic tolerance .
19462377	0	CD4	22,25	CTLA-4	0,6	CD4	CTLA-4	920	1493	Gene	Gene	Treg|compound|START_ENTITY required|nmod|Treg required|nsubjpass|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19462377	0	CD4	48,51	CTLA-4	0,6	CD4	CTLA-4	920	1493	Gene	Gene	proliferation|compound|START_ENTITY control|dobj|proliferation required|xcomp|control required|nsubjpass|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19479036	0	CD4	26,29	CTLA-4	7,13	CD4	CTLA-4	920	1493	Gene	Gene	migration|compound|START_ENTITY determines|dobj|migration determines|nsubj|CD152 CD152|appos|END_ENTITY	CD152 -LRB- CTLA-4 -RRB- determines CD4 T cell migration in vitro and in vivo .
21170302	0	CD4	0,3	CTLA-4	74,80	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ prevent|nsubj|cells prevent|dobj|cerebral_malaria cerebral_malaria|nmod|END_ENTITY	CD4 + natural regulatory T cells prevent experimental cerebral_malaria via CTLA-4 when expanded in vivo .
21478403	0	CD4	70,73	CTLA-4	12,18	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generation|nmod|cells decreases|dobj|generation decreases|nsubj|Blockade Blockade|nmod|END_ENTITY	Blockade of CTLA-4 decreases the generation of multifunctional memory CD4 + T cells in vivo .
21620894	0	CD4	25,28	CTLA-4	4,10	CD4	CTLA-4	920	1493	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Low CTLA-4 expression in CD4 + helper T-cells in patients with fulminant type 1 diabetes .
22105491	0	CD4	19,22	CTLA-4	82,88	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells ablates|nsubj|engagement ablates|dobj|expression expression|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
22403258	0	CD4	56,59	CTLA-4	9,15	CD4	CTLA-4	920	1493	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Basis of CTLA-4 function in regulatory and conventional CD4 -LRB- + -RRB- T cells .
22749982	0	CD4	61,64	CTLA-4	20,26	CD4	CTLA-4	920	1493	Gene	Gene	CD25|compound|START_ENTITY Induction|dep|CD25 Induction|nmod|CD152 CD152|appos|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22878899	0	CD4	30,33	CTLA-4	34,40	CD4	CTLA-4	920	1493	Gene	Gene	frequency|compound|START_ENTITY frequency|compound|END_ENTITY	T cell profiling reveals high CD4 + CTLA-4 + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment .
24173147	0	CD4	118,121	CTLA-4	13,19	CD4	CTLA-4	920	1493	Gene	Gene	proliferation|compound|START_ENTITY NFAT1|nmod|proliferation associated|nmod|NFAT1 associated|nsubjpass|expression expression|compound|END_ENTITY	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
24173147	0	CD4	40,43	CTLA-4	13,19	CD4	CTLA-4	920	1493	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
24312642	0	CD4	52,55	CTLA-4	67,73	CD4	CTLA-4	920	1493	Gene	Gene	Treg|compound|START_ENTITY Treg|nmod|manner manner|amod|dependent dependent|amod|END_ENTITY	ICOS regulates the generation and function of human CD4 + Treg in a CTLA-4 dependent manner .
25241783	0	CD4	78,81	CTLA-4	46,52	CD4	CTLA-4	404704(Tax:9823)	397286(Tax:9823)	Gene	Gene	cells|compound|START_ENTITY molecules|nmod|cells molecules|amod|END_ENTITY	-LSB- Expression levels of co-inhibitory molecules CTLA-4 , LAG-3 , PD-1 and CD39 on CD4 T cells correlate with progression of non-small_cell_lung_cancer -RSB- .
26601915	0	CD4	51,54	CTLA-4	58,64	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|compound|START_ENTITY regulates|iobj|+ regulates|dobj|expression expression|compound|END_ENTITY	Glutamate_receptor_interacting_protein_1 regulates CD4 -LRB- + -RRB- CTLA-4 expression and transplant rejection .
8113677	0	CD4	96,99	CTLA-4	45,51	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells show|dobj|expansion show|nsubj|Mice Mice|amod|transgenic transgenic|nmod|form form|nmod|END_ENTITY	Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4 + T cells and defective antibody production in vivo .
9493288	0	CD4	66,69	CTLA-4	40,46	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Nonresponsiveness and susceptibility to CTLA-4 of antigen-exposed CD4 T cells are not regulated by the Bcl-2 family of apoptotic mediators , but can be restored by IL-2 .
9551948	0	CD4	58,61	CTLA-4	0,6	CD4	CTLA-4	920	1493	Gene	Gene	cells|compound|START_ENTITY delivers|nmod|cells delivers|nsubj|ligation ligation|compound|END_ENTITY	CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X -LRB- L -RRB- induction .
9707604	0	CD4	35,38	CTLA-4	67,73	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	T|compound|START_ENTITY death|nmod|T lymphocytes|nsubj|death lymphocytes|dep|induced induced|nmod|crosslinking crosslinking|compound|END_ENTITY	Fas-independent death of activated CD4 -LRB- + -RRB- T lymphocytes induced by CTLA-4 crosslinking .
9749982	0	CD4	48,51	CTLA-4	14,20	CD4	CTLA-4	920	1493	Gene	Gene	thymocytes|compound|START_ENTITY Expression|nmod|thymocytes Expression|nmod|END_ENTITY	Expression of CTLA-4 -LRB- CD152 -RRB- on human medullary CD4 + thymocytes .
9815262	0	CD4	139,142	CTLA-4	59,65	CD4	CTLA-4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	T|compound|START_ENTITY production|nmod|T factor|dep|production cells|compound|factor transforming|dobj|cells induces|xcomp|transforming induces|nsubj|Engagement Engagement|nmod|cytotoxic_T_lymphocyte-associated_antigen_4 cytotoxic_T_lymphocyte-associated_antigen_4|appos|END_ENTITY	Engagement of cytotoxic_T_lymphocyte-associated_antigen_4 -LRB- CTLA-4 -RRB- induces transforming growth factor beta -LRB- TGF-beta -RRB- production by murine CD4 -LRB- + -RRB- T cells .
9834064	0	CD4	73,76	CTLA-4	21,27	CD4	CTLA-4	920	1493	Gene	Gene	activation|compound|START_ENTITY memory|nmod|activation role|nmod|memory role|nmod|END_ENTITY	Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation .
15322168	0	CD4	25,28	CTLA4	34,39	CD4	CTLA4	920	1493	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional maturation of CD4 + CD25 + CTLA4 + CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens .
16224273	0	CD4	69,72	CTLA4	78,83	CD4	CTLA4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	LF 15-0195 generates synergistic tolerance by promoting formation of CD4 + CD25 + CTLA4 + T cells .
18641318	0	CD4	63,66	CTLA4	0,5	CD4	CTLA4	920	1493	Gene	Gene	homeostasis|compound|START_ENTITY indicator|nmod|homeostasis indicator|nsubj|expression expression|compound|END_ENTITY	CTLA4 expression is an indicator and regulator of steady-state CD4 + FoxP3 + T cell homeostasis .
19173720	0	CD4	17,20	CTLA4	83,88	CD4	CTLA4	920	1493	Gene	Gene	Treg|compound|START_ENTITY frequency|nmod|Treg frequency|dep|trait trait|acl|associated associated|nmod|variants variants|compound|END_ENTITY	Low frequency of CD4 + CD25 + Treg in SLE patients : a heritable trait associated with CTLA4 and TGFbeta gene variants .
15871132	0	CD4	95,98	CX3CR1	25,31	CD4	CX3CR1	920	1524	Gene	Gene	+|nummod|START_ENTITY lymphocyte|nmod:npmod|+ count|amod|lymphocyte children|nmod|count progression|nmod|children predict|dobj|progression predict|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4 + lymphocyte count and HIV-1 RNA load .
17804530	0	CD4	55,58	CX3CR1	44,50	CD4	CX3CR1	920	1524	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nmod|fractalkine_receptor fractalkine_receptor|appos|END_ENTITY	Surface expression of fractalkine_receptor -LRB- CX3CR1 -RRB- on CD4 + / CD28 T cells in RA patients and correlation with atherosclerotic_damage .
22313962	0	CD4	36,39	CX3CR1	40,46	CD4	CX3CR1	920	1524	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A role for cytomegalovirus-specific CD4 + CX3CR1 + T cells and cytomegalovirus-induced T-cell immunopathology in HIV-associated atherosclerosis .
26195744	0	CD4	66,69	CX3CR1	48,54	CD4	CX3CR1	920	1524	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Dengue_virus_infection elicits highly polarized CX3CR1 + cytotoxic CD4 + T cells associated with protective immunity .
26195744	0	CD4	66,69	CX3CR1	48,54	CD4	CX3CR1	920	1524	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Dengue_virus_infection elicits highly polarized CX3CR1 + cytotoxic CD4 + T cells associated with protective immunity .
14688334	0	CD4	6,9	CXCR1	0,5	CD4	CXCR1	920	3577	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CXCR1 + CD4 + T cells in human allergic_disease .
21048114	0	CD4	21,24	CXCR1	133,138	CD4	CXCR1	920	3577	Gene	Gene	Enrichment|nmod|START_ENTITY cells|dep|Enrichment _|dep|cells _|nmod|induction induction|nmod|END_ENTITY	Enrichment of Foxp3 + CD4 regulatory T cells in migrated_T cells to IL-6 - _ and_IL-8-expressing tumors through predominant induction of CXCR1 by IL-6 .
12960302	0	CD4	41,44	CXCR3	0,5	CD4	CXCR3	920	2833	Gene	Gene	differentiation|compound|START_ENTITY pathway|nmod|differentiation induced|nmod|pathway induced|nsubjpass|END_ENTITY	CXCR3 is induced early on the pathway of CD4 + T cell differentiation and bridges central and peripheral functions .
15265673	0	CD4	12,15	CXCR3	0,5	CD4	CXCR3	920	2833	Gene	Gene	lymphocytes|compound|START_ENTITY marks|dobj|lymphocytes marks|nsubj|END_ENTITY	CXCR3 marks CD4 + memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer .
15708587	0	CD4	39,42	CXCR3	0,5	CD4	CXCR3	920	2833	Gene	Gene	recruitment|compound|START_ENTITY required|nmod|recruitment required|nsubjpass|END_ENTITY	CXCR3 , IP-10 , and Mig are required for CD4 + T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance .
15884054	0	CD4	125,128	CXCR3	0,5	CD4	CXCR3	24932(Tax:10116)	84475(Tax:10116)	Gene	Gene	subsets|compound|START_ENTITY dermal|nmod|subsets required|xcomp|dermal required|nsubjpass|END_ENTITY	CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells : differential requirements by CD4 and CD8 memory subsets .
16427705	0	CD4	59,62	CXCR3	50,55	CD4	CXCR3	920	2833	Gene	Gene	cells|compound|START_ENTITY chemokine|nmod|cells chemokine|dobj|END_ENTITY	Altered expression of Th1-type chemokine receptor CXCR3 on CD4 + T cells in myasthenia_gravis patients .
16455991	0	CD4	50,53	CXCR3	19,24	CD4	CXCR3	920	2833	Gene	Gene	signaling|compound|START_ENTITY dependent|nsubj|signaling END_ENTITY|parataxis|dependent	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
16479546	0	CD4	32,35	CXCR3	23,28	CD4	CXCR3	12504(Tax:10090)	12766(Tax:10090)	Gene	Gene	+|compound|START_ENTITY roles|nmod|+ roles|nmod|END_ENTITY	Differential roles for CXCR3 in CD4 + and CD8 + T cell trafficking following viral_infection of the CNS .
16670334	0	CD4	59,62	CXCR3	30,35	CD4	CXCR3	12504(Tax:10090)	12766(Tax:10090)	Gene	Gene	liver_damage|compound|START_ENTITY induction|nmod|liver_damage induction|nummod|END_ENTITY	Fas ligand is responsible for CXCR3 chemokine induction in CD4 + T cell-dependent liver_damage .
17374135	0	CD4	154,157	CXCR3	147,152	CD4	CXCR3	920	2833	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chemokine and chemokine_receptor analysis reveals elevated interferon-inducible_protein-10 _ -LRB- IP -RRB- -10 / CXCL10 levels and increased number of CCR5 + and CXCR3 + CD4 T cells in synovial fluid of patients with enthesitis-related_arthritis -LRB- ERA -RRB- .
19116922	0	CD4	6,9	CXCR3	0,5	CD4	CXCR3	920	2833	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CXCR3 + CD4 + T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute_nephritis flares in systemic_lupus_erythematosus patients .
19293635	0	CD4	39,42	CXCR3	22,27	CD4	CXCR3	920	2833	Gene	Gene	cells|amod|START_ENTITY enhances|nsubj|cells enhances|nsubj|addition addition|nmod|CCR4 CCR4|compound|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
19423402	0	CD4	31,34	CXCR3	0,5	CD4	CXCR3	920	2833	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	CXCR3 expression on peripheral CD4 + T cells as a predictive marker of response to treatment in chronic hepatitis_C .
19734208	0	CD4	40,43	CXCR3	0,5	CD4	CXCR3	12504(Tax:10090)	12766(Tax:10090)	Gene	Gene	migration|compound|START_ENTITY directs|dobj|migration directs|nsubj|END_ENTITY	CXCR3 directs antigen-specific effector CD4 + T cell migration to the lung during parainfluenza virus infection .
21357438	0	CD4	30,33	CXCR3	10,15	CD4	CXCR3	920	2833	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Decreased CXCR3 expression in CD4 + T cells exposed to asbestos or derived from asbestos-exposed patients .
21538345	0	CD4	17,20	CXCR3	82,87	CD4	CXCR3	920	2833	Gene	Gene	Subsets|nmod|START_ENTITY express|nsubj|Subsets express|dobj|END_ENTITY	Subsets of human CD4 -LRB- + -RRB- regulatory T cells express the peripheral homing receptor CXCR3 .
22670785	0	CD4	25,28	CXCR3	41,46	CD4	CXCR3	920	2833	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripherally circulating CD4 FOXP3 CXCR3 T regulatory cells correlate with renal allograft function .
23012327	0	CD4	48,51	CXCR3	41,46	CD4	CXCR3	920	2833	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chemokine-mediated tissue recruitment of CXCR3 + CD4 + T cells plays a major role in the pathogenesis of chronic GVHD .
23123063	0	CD4	72,75	CXCR3	0,5	CD4	CXCR3	12504(Tax:10090)	12766(Tax:10090)	Gene	Gene	T|compound|START_ENTITY helper|nsubj|T optimize|ccomp|helper optimize|nsubj|interactions interactions|nummod|END_ENTITY	CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4 + T helper 1 cell differentiation .
26183767	0	CD4	0,3	CXCR3	4,9	CD4	CXCR3	920	2833	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CXCR3 + T cells and plasmacytoid dendritic cells drive accelerated atherosclerosis associated with systemic_lupus_erythematosus .
26657511	0	CD4	76,79	CXCR3	30,35	CD4	CXCR3	12504(Tax:10090)	12766(Tax:10090)	Gene	Gene	subsets|compound|START_ENTITY development|nmod|subsets control|dobj|development control|nsubj|pathways pathways|nmod|END_ENTITY	Biased signaling pathways via CXCR3 control the development and function of CD4 + T cell subsets .
26807971	0	CD4	55,58	CXCR3	37,42	CD4	CXCR3	920	2833	Gene	Gene	T-cells|compound|START_ENTITY +|dobj|T-cells +|nsubj|Persistence Persistence|nmod|DNA DNA|nmod|END_ENTITY	Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4 + T-cells in HIV-infected individuals on antiretroviral therapy .
10229873	0	CD4	33,36	CXCR4	69,74	CD4	CXCR4	920	7852	Gene	Gene	chemotaxis|compound|START_ENTITY mediates|dobj|chemotaxis mediates|nmod|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10628813	0	CD4	48,51	CXCR4	28,33	CD4	CXCR4	920	7852	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ expression|nmod|cells expression|nummod|END_ENTITY	Influenza virus upregulates CXCR4 expression in CD4 + cells .
10823791	0	CD4	99,102	CXCR4	81,86	CD4	CXCR4	920	7852	Gene	Gene	cells|nummod|START_ENTITY coreceptors|nmod|cells coreceptors|dobj|END_ENTITY	Thalidomide suppresses Up-regulation of human_immunodeficiency_virus coreceptors CXCR4 and CCR5 on CD4 + T cells in humans .
10864648	0	CD4	125,128	CXCR4	130,135	CD4	CXCR4	920	7852	Gene	Gene	CCR5|compound|START_ENTITY CCR5|appos|END_ENTITY	Glycosphingolipids promote entry of a broad range of human_immunodeficiency_virus_type_1 isolates into cell lines expressing CD4 , CXCR4 , and/or CCR5 .
10864687	0	CD4	33,36	CXCR4	48,53	CD4	CXCR4	920	7852	Gene	Gene	infection|nmod|START_ENTITY END_ENTITY|nsubj|infection	CD4-independent infection of two CD4 -LRB- - -RRB- / CCR5 -LRB- - -RRB- / CXCR4 -LRB- + -RRB- pre-T-cell lines by human and simian immunodeficiency viruses .
10878344	0	CD4	78,81	CXCR4	58,63	CD4	IL-15	920	3600	Gene	Gene	memory|compound|START_ENTITY expression|nmod|memory expression|nummod|END_ENTITY	Cytokines and cell surface molecules independently induce CXCR4 expression on CD4 + CCR7 + human memory T cells .
10967018	0	CD4	58,61	CXCR4	92,97	CD4	CXCR4	920	7852	Gene	Gene	START_ENTITY|appos|CD45RO CD45RO|appos|END_ENTITY	Adenoids provide a microenvironment for the generation of CD4 -LRB- + -RRB- , CD45RO -LRB- + -RRB- , L-selectin -LRB- - -RRB- , CXCR4 -LRB- + -RRB- , CCR5 -LRB- + -RRB- T lymphocytes , a lymphocyte phenotype found in the middle_ear_effusion .
11023494	0	CD4	51,54	CXCR4	33,38	CD4	CXCR4	920	7852	Gene	Gene	T|compound|START_ENTITY Up-regulation|nmod|T Up-regulation|nmod|END_ENTITY	Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4 -LRB- + -RRB- T cells during human endotoxemia and after stimulation with -LRB- myco -RRB- bacterial antigens : the role of cytokines .
11181132	0	CD4	97,100	CXCR4	79,84	CD4	CXCR4	920	7852	Gene	Gene	increased|nmod|START_ENTITY increased|dobj|expression expression|nmod|END_ENTITY	Patients with active tuberculosis have increased expression of HIV coreceptors CXCR4 and CCR5 on CD4 -LRB- + -RRB- T cells .
11943153	0	CD4	57,60	CXCR4	66,71	CD4	CXCR4	920	7852	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of N-glycans and SDF-1alpha on the coassociation of CD4 with CXCR4 at the plasma membrane of monocytic cells and blood lymphocytes .
12193696	0	CD4	72,75	CXCR4	52,57	CD4	CXCR4	920	7852	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Follicular dendritic cell-mediated up-regulation of CXCR4 expression on CD4 T cells and HIV pathogenesis .
12803997	0	CD4	78,81	CXCR4	71,76	CD4	CXCR4	920	7852	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Early viral load and CD4 + T cell count , but not percentage of CCR5 + or CXCR4 + CD4 + T cells , are associated with R5-to-X4_HIV_type_1 virus evolution .
14622278	0	CD4	18,21	CXCR4	61,66	CD4	CXCR4	920	7852	Gene	Gene	antibodies|compound|START_ENTITY Identification|nmod|antibodies Identification|nmod|selection selection|nummod|END_ENTITY	Identification of CD4 and transferrin_receptor antibodies by CXCR4 antibody-guided Pathfinder selection .
14990729	0	CD4	34,37	CXCR4	81,86	CD4	CXCR4	920	7852	Gene	Gene	cells|nummod|START_ENTITY targets|dobj|cells targets|advcl|interacting interacting|nmod|receptors receptors|compound|END_ENTITY	Extracellular Nef protein targets CD4 + T cells for apoptosis by interacting with CXCR4 surface receptors .
15000561	0	CD4	49,52	CXCR4	40,45	CD4	CXCR4	920	7852	Gene	Gene	T-cells|compound|START_ENTITY END_ENTITY|nmod|T-cells	Increased expression of HIV co-receptor CXCR4 on CD4 + T-cells in patients with active visceral_leishmaniasis .
15178707	0	CD4	82,85	CXCR4	37,42	CD4	CXCR4	920	7852	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells END_ENTITY|dobj|expression	Lysophosphatidylcholine up-regulates CXCR4 chemokine_receptor expression in human CD4 T cells .
16249699	0	CD4	50,53	CXCR4	63,68	CD4	CXCR4	920	7852	Gene	Gene	HIV-1|nmod|START_ENTITY R5_HIV-1|nmod|HIV-1 END_ENTITY|amod|R5_HIV-1	Enhanced replication of R5_HIV-1 over X4 HIV-1 in CD4 -LRB- + -RRB- CCR5 -LRB- + -RRB- CXCR4 -LRB- + -RRB- T cells .
17853408	0	CD4	93,96	CXCR4	27,32	CD4	CXCR4	920	7852	Gene	Gene	cells|compound|START_ENTITY pathway|nmod|cells Up-regulation|dep|pathway Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation of leukocyte CXCR4 expression by sulfatide : an L-selectin-dependent pathway on CD4 + T cells .
19779716	0	CD4	0,3	CXCR4	15,20	CD4	CXCR4	920	7852	Gene	Gene	CD45RA|compound|START_ENTITY CD45RA|acl|END_ENTITY	CD4 -LRB- + -RRB- CD45RA -LRB- + -RRB- CXCR4 -LRB- + -RRB- lymphocytes are inversely associated with progression in stages I-III melanoma patients .
20038787	0	CD4	11,14	CXCR4	113,118	CD4	CXCR4	920	7852	Gene	Gene	lymphocytopenia|compound|START_ENTITY associated|nsubjpass|lymphocytopenia associated|nmod|expression expression|nmod|END_ENTITY	Idiopathic CD4 + T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4 .
20051874	0	CD4	117,120	CXCR4	165,170	CD4	CXCR4	920	7852	Gene	Gene	cells|compound|START_ENTITY phenotype|nmod|cells efficiently|nmod|phenotype expressing|advmod|efficiently expressing|dobj|levels levels|nmod|END_ENTITY	Pairwise comparison_of_isogenic_HIV-1_viruses : R5 phenotype replicates more efficiently than X4 phenotype in primary CD4 + T cells expressing physiological levels of CXCR4 .
20300007	0	CD4	89,92	CXCR4	60,65	CD4	CXCR4	920	7852	Gene	Gene	T-cells|compound|START_ENTITY END_ENTITY|nmod|T-cells	The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4 -LRB- + -RRB- T-cells and monocytes and is superior to valproic_acid for latent HIV-1 expression in vitro .
20728351	0	CD4	0,3	CXCR4	79,84	CD4	CXCR4	920	7852	Gene	Gene	mimics|nsubj|START_ENTITY mimics|xcomp|targeting targeting|nmod|antagonist antagonist|compound|END_ENTITY	CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist .
20732363	0	CD4	125,128	CXCR4	107,112	CD4	CXCR4	920	7852	Gene	Gene	T-cells|compound|START_ENTITY induces|nmod|T-cells induces|dobj|downregulation downregulation|nmod|END_ENTITY	Monoclonal antibody-assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4 + T-cells .
20861743	0	CD4	5,8	CXCR4	27,32	CD4	CXCR4	920	7852	Gene	Gene	T-cell|compound|START_ENTITY density|compound|T-cell density|compound|END_ENTITY	High CD4 -LRB- + -RRB- T-cell surface CXCR4 density as a risk factor for R5 to X4 switch in the course of HIV-1_infection .
22532671	0	CD4	54,57	CXCR4	27,32	CD4	CXCR4	12504(Tax:10090)	12767(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY identifies|dobj|cells identifies|nsubj|Single Single|nmod|END_ENTITY	Single and coexpression of CXCR4 and CXCR5 identifies CD4 T helper cells in distinct lymph node niches during influenza_virus_infection .
22568557	0	CD4	119,122	CXCR4	22,27	CD4	CXCR4	920	7852	Gene	Gene	T|compound|START_ENTITY migration|nmod|T CXCL12-dependent|dep|migration cells|amod|CXCL12-dependent contributes|nmod|cells contributes|nsubj|regulation regulation|nmod|expression expression|nummod|END_ENTITY	Altered regulation of CXCR4 expression during aging contributes to increased CXCL12-dependent chemotactic migration of CD4 -LRB- + -RRB- T cells .
9108384	0	CD4	45,48	CXCR4	134,139	CD4	CXCR4	920	7852	Gene	Gene	resistant|dep|START_ENTITY transfection|amod|resistant transfection|amod|susceptible susceptible|nmod|END_ENTITY	Human_immunodeficiency_virus -LRB- HIV -RRB- - resistant CD4 + UT-7 megakaryocytic human cell line becomes highly HIV-1_and_HIV-2 susceptible upon CXCR4 transfection : induction of cell differentiation by HIV-1_infection .
9770524	0	CD4	61,64	CXCR4	0,5	CD4	CXCR4	920	7852	Gene	Gene	T|compound|START_ENTITY death|nmod|T cells|nsubj|death mediate|xcomp|cells mediate|nsubj|END_ENTITY	CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4 -LRB- + -RRB- T cells .
9823770	0	CD4	64,67	CXCR4	38,43	CD4	CXCR4	920	7852	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4 + T lymphocytes and enhance HIV-1 replication .
9892690	0	CD4	43,46	CXCR4	0,5	CD4	CXCR4	920	7852	Gene	Gene	depletion|compound|START_ENTITY trigger|dobj|depletion sufficient|xcomp|trigger sufficient|nsubj|utilization utilization|compound|END_ENTITY	CXCR4 utilization is sufficient to trigger CD4 + T cell depletion in HIV-1-infected human lymphoid tissue .
12354388	0	CD4	0,3	CXCR5	92,97	CD4	CXCR5	12504(Tax:10090)	12145(Tax:10090)	Gene	Gene	CD3|compound|START_ENTITY CD3|dep|role role|nmod|activation activation|nmod|END_ENTITY	CD4 + CD3 - cells induce Peyer 's patch development : role of alpha4beta1 integrin activation by CXCR5 .
16982935	0	CD4	63,66	CXCR5	57,62	CD4	CXCR5	920	643	Gene	Gene	center|compound|START_ENTITY center|compound|END_ENTITY	ICOS_deficiency is associated with a severe reduction of CXCR5 + CD4 germinal center Th cells .
18941193	0	CD4	156,159	CXCR5	167,172	CD4	CXCR5	12504(Tax:10090)	12145(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
21270407	0	CD4	7,10	CXCR5	32,37	CD4	CXCR5	920	643	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|express express|ccomp|provide provide|nsubj|END_ENTITY	Memory CD4 T cells that express CXCR5 provide accelerated help to B cells .
21471443	0	CD4	38,41	CXCR5	0,5	CD4	CXCR5	920	643	Gene	Gene	T|compound|START_ENTITY expressing|dobj|T END_ENTITY|acl|expressing	CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses .
22575453	0	CD4	31,34	CXCR5	38,43	CD4	CXCR5	920	643	Gene	Gene	CCR6|nummod|START_ENTITY CCR6|compound|END_ENTITY	Role of the frequency of blood CD4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- CCR6 -LRB- + -RRB- T cells in autoimmunity in patients with Sj gren 's syndrome .
23403044	0	CD4	6,9	CXCR5	17,22	CD4	CXCR5	920	643	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Blood CD4 + CD45RO + CXCR5 + T cells are decreased but partially functional in signal_transducer_and_activator_of_transcription_3 deficiency .
23527264	0	CD4	34,37	CXCR5	70,75	CD4	CXCR5	404704(Tax:9823)	100515679	Gene	Gene	START_ENTITY|ccomp|express express|dobj|levels levels|nmod|END_ENTITY	Rhesus_macaque lymph node PD-1 -LRB- hi -RRB- CD4 + T cells express high levels of CXCR5 and IL-21 and display a CCR7 -LRB- lo -RRB- ICOS+B cl6 + T-follicular helper -LRB- Tfh -RRB- cell phenotype .
23807677	0	CD4	26,29	CXCR5	31,36	CD4	CXCR5	920	643	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Association of peripheral CD4 + CXCR5 + T cells with chronic_lymphocytic_leukemia .
24291746	0	CD4	6,9	CXCR5	0,5	CD4	CXCR5	920	643	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CXCR5 + CD4 + follicular helper T cells accumulate in resting human lymph nodes and have superior B cell helper activity .
24333338	0	CD4	22,25	CXCR5	28,33	CD4	CXCR5	920	643	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	A higher frequency of CD4 CXCR5 T follicular helper cells in patients with newly diagnosed IgA_nephropathy .
24519063	0	CD4	27,30	CXCR5	31,36	CD4	CXCR5	920	643	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Upregulation of peripheral CD4 + CXCR5 + T cells in osteosarcoma .
24966908	0	CD4	0,3	CXCR5	4,9	CD4	CXCR5	920	643	Gene	Gene	helper|compound|START_ENTITY helper|compound|END_ENTITY	CD4 + CXCR5 + follicular helper T cells in salivary gland promote B cells maturation in patients with primary_Sjogren 's _ syndrome .
25042122	0	CD4	7,10	CXCR5	0,5	CD4	CXCR5	920	643	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CXCR5 + CD4 + T follicular helper cells participate in the pathogenesis of primary_biliary_cirrhosis .
25177353	0	CD4	87,90	CXCR5	97,102	CD4	CXCR5	920	643	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The effect of aging on the frequency , phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells : comparison of aged and young subjects .
25199644	0	CD4	52,55	CXCR5	74,79	CD4	CXCR5	920	643	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs END_ENTITY|dep|Bregs	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25351463	0	CD4	29,32	CXCR5	33,38	CD4	CXCR5	920	643	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Dysregulation of circulating CD4 + CXCR5 + T cells in type_2_diabetes_mellitus .
25654980	0	CD4	18,21	CXCR5	12,17	CD4	CXCR5	920	643	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CXCR5 + CD4 + helper T cells in systemic_lupus_erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production .
26116502	0	CD4	95,98	CXCR5	77,82	CD4	CXCR5	713807(Tax:9544)	701792(Tax:9544)	Gene	Gene	Responses|nummod|START_ENTITY Codelivery|dep|Responses Codelivery|nmod|Protein Protein|nmod|Alum Alum|nmod|+ +|compound|END_ENTITY	Codelivery of Envelope Protein in Alum with MVA_Vaccine Induces CXCR3-Biased CXCR5 + and CXCR5 - CD4 T Cell Responses in Rhesus_Macaques .
26333070	0	CD4	18,21	CXCR5	12,17	CD4	CXCR5	920	643	Gene	Gene	Cell|nummod|START_ENTITY +|dobj|Cell +|nsubj|END_ENTITY	Circulating CXCR5 + CD4 + T Follicular-Like Helper Cell and Memory B Cell Responses to Human_Papillomavirus Vaccines .
26425132	0	CD4	99,102	CXCR5	109,114	CD4	CXCR5	920	643	Gene	Gene	follicular|compound|START_ENTITY follicular|compound|END_ENTITY	Erratum to : The effect of aging on the frequency , phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells : comparison of aged and young subjects .
26559315	0	CD4	20,23	CXCR5	24,29	CD4	CXCR5	404704(Tax:9823)	100515679	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Higher Frequency of CD4 + CXCR5 + ICOS+PD 1 + T Follicular Helper Cells in Patients With Infectious_Mononucleosis .
26818544	0	CD4	0,3	CXCR5	4,9	CD4	CXCR5	920	643	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
23840334	0	CD4	41,44	CXCR6	19,24	CD4	CXCR6	920	10663	Gene	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Distinct Roles for CXCR6 -LRB- + -RRB- and CXCR6 -LRB- - -RRB- CD4 -LRB- + -RRB- T Cells in the Pathogenesis of Chronic_Colitis .
19801520	0	CD4	95,98	Cbl-b	24,29	CD4	Cbl-b	920	868	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells expansion|nmod|activity regulates|dobj|expansion regulates|nsubj|END_ENTITY	The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells .
21248249	0	CD4	59,62	Cbl-b	24,29	CD4	Cbl-b	12504(Tax:10090)	208650(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY control|nmod|cells Visualizing|nmod|control Visualizing|dobj|role role|nmod|END_ENTITY	Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes .
22884358	0	CD4	83,86	Cbl-b	17,22	CD4	Cbl-b	920	868	Gene	Gene	subsets|compound|START_ENTITY inhibition|nmod|subsets associated|nmod|inhibition associated|nsubjpass|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4 + T-cell subsets .
25560411	0	CD4	51,54	Cbl-b	20,25	CD4	Cbl-b	12504(Tax:10090)	208650(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
18178847	0	CD4	46,49	Cd55	107,111	CD4	Cd55	12504(Tax:10090)	13136(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY analysis|nmod|Cells identifies|nsubj|analysis identifies|dobj|END_ENTITY	Genome-wide microarray expression analysis of CD4 + T Cells from nonobese diabetic congenic mice identifies Cd55 -LRB- Daf1 -RRB- and Acadl as candidate genes for type_1_diabetes .
11145678	0	CD4	46,49	Chemokine_receptor	0,18	CD4	Chemokine receptor	920	7852	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Chemokine_receptor expression and function in CD4 + T lymphocytes with regulatory activity .
21085612	0	CD4	33,36	DCIR	14,18	CD4	DCIR	920	50856	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	HIV-1 induces DCIR expression in CD4 + T cells .
17492476	0	CD4	77,80	DNA_methyltransferase_1	39,62	CD4	DNA methyltransferase 1	920	1786	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	Prevalence of ZAP-70 , LAT , SLP-76 , and DNA_methyltransferase_1 expression in CD4 + T cells of patients with systemic_lupus_erythematosus .
18194272	0	CD4	72,75	DNMT1	44,49	CD4	DNMT1	920	1786	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Transcript levels of DNA methyltransferases DNMT1 , DNMT3A and DNMT3B in CD4 + T cells from patients with systemic_lupus_erythematosus .
23706494	0	CD4	46,49	DNMT1	106,111	CD4	DNMT1	920	1786	Gene	Gene	cells|compound|START_ENTITY hypomethylation|nmod|cells enhances|dobj|hypomethylation enhances|nmod|systemic_lupus_erythematosus systemic_lupus_erythematosus|nmod|activity activity|compound|END_ENTITY	Ultraviolet B enhances DNA hypomethylation of CD4 + T cells in systemic_lupus_erythematosus via inhibiting DNMT1 catalytic activity .
26770634	0	CD4	69,72	DNMT1	38,43	CD4	DNMT1	920	1786	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	A correlation study on the effects of DNMT1 on methylation levels in CD4 -LRB- + -RRB- T cells of SLE patients .
22219644	0	CD4	34,37	DR3	16,19	CD4	DR3	12504(Tax:10090)	85030(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Upregulation of DR3 expression in CD4 T cells promotes secretion of IL-17 in experimental autoimmune uveitis .
23589621	0	CD4	34,37	Dopamine_receptor_D3	0,20	CD4	Dopamine receptor D3	12504(Tax:10090)	13490(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells END_ENTITY|acl|expressed	Dopamine_receptor_D3 expressed on CD4 + T cells favors neurodegeneration of dopaminergic neurons during Parkinson 's _ disease .
25227984	0	CD4	41,44	Dual-specificity_phosphatase_6	0,30	CD4	Dual-specificity phosphatase 6	12504(Tax:10090)	67603(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Dual-specificity_phosphatase_6 regulates CD4 -LRB- + -RRB- T-cell functions and restrains spontaneous_colitis in IL-10-deficient mice .
11123285	0	CD4	113,116	E-selectin	64,74	CD4	E-selectin	920	6401	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
14634085	0	CD4	65,68	E-selectin	46,56	CD4	E-selectin	920	6401	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	In vitro differentiation from naive to mature E-selectin binding CD4 T cells : acquisition of skin-homing properties occurs independently of cutaneous lymphocyte antigen expression .
25560411	0	CD4	51,54	E3_Ubiquitin_Ligase	0,19	CD4	E3 Ubiquitin Ligase	12504(Tax:10090)	68350(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
15210761	0	CD4	104,107	E3_ubiquitin_ligase	46,65	CD4	E3 ubiquitin ligase	12504(Tax:10090)	68350(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells necessary|nmod|induction necessary|nsubj|gene gene|acl|related related|xcomp|anergy anergy|nmod|lymphocytes lymphocytes|appos|END_ENTITY	The gene related to anergy in lymphocytes , an E3_ubiquitin_ligase , is necessary for anergy induction in CD4 T cells .
15061764	0	CD4	0,3	EL4	18,21	CD4	EL4	12504(Tax:10090)	111979(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection .
10347164	0	CD4	30,33	Elf-1	21,26	CD4	Elf-1	920	1997	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	A potential role for Elf-1 in CD4 promoter function .
7935370	0	CD4	46,49	Elf-1	0,5	CD4	Elf-1	12504(Tax:10090)	13709(Tax:10090)	Gene	Gene	enhancer|compound|START_ENTITY element|nmod|enhancer binds|nmod|element binds|nsubj|END_ENTITY	Elf-1 binds to a critical element in a second CD4 enhancer .
10375528	0	CD4	27,30	Env	69,72	CD4	Env	920	155971(Tax:11676)	Gene	Gene	expression|nmod|START_ENTITY reduces|nsubj|expression reduces|advcl|blocking blocking|dobj|incorporation incorporation|compound|END_ENTITY	Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef - and Vpu-inhibitable manner .
10590121	0	CD4	100,103	Env	114,117	CD4	Env	920	155971(Tax:11676)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Sequential CD4-coreceptor interactions in human_immunodeficiency_virus_type_1 Env function : soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120 .
10590121	0	CD4	100,103	Env	78,81	CD4	Env	920	155971(Tax:11676)	Gene	Gene	activates|nsubj|START_ENTITY function|parataxis|activates function|nsubj|interactions interactions|nmod|END_ENTITY	Sequential CD4-coreceptor interactions in human_immunodeficiency_virus_type_1 Env function : soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120 .
12816953	0	CD4	9,12	Env	90,93	CD4	Env	920	155971(Tax:11676)	Gene	Gene	alleles|nummod|START_ENTITY associated|nsubjpass|alleles associated|nmod|incorporation incorporation|compound|END_ENTITY	Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication .
1354446	0	CD4	61,64	Env	40,43	CD4	Env	920	30816	Gene	Gene	+|compound|START_ENTITY proteins|nmod|+ proteins|appos|END_ENTITY	Equivalent recognition of HIV proteins , Env , Gag and Pol , by CD4 + and CD8 + cytotoxic T-lymphocytes .
15310467	0	CD4	188,191	Env	97,100	CD4	Env	920	155971(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY form|nmod|cells derived|xcomp|form derived|nsubj|Enhancement Enhancement|nmod|infectivity infectivity|acl|replacing replacing|dobj|region region|nmod|END_ENTITY	Enhancement of human_immunodeficiency_virus_type_1 infectivity by replacing the region including Env derived from defective particles with an ability to form particle-mediated syncytia in CD4 + T cells .
15956548	0	CD4	20,23	Env	119,122	CD4	Env	920	30816	Gene	Gene	immunity|compound|START_ENTITY immunity|nmod|prime prime|nmod|END_ENTITY	Enhanced breadth of CD4 T-cell immunity by DNA prime and adenovirus boost immunization to human_immunodeficiency_virus Env and Gag immunogens .
16371160	0	CD4	147,150	Env	28,31	CD4	Env	920	155971(Tax:11676)	Gene	Gene	rationale|nmod|START_ENTITY reveals|dobj|rationale reveals|nsubj|infection infection|nmod|END_ENTITY	Targeted infection of HIV-1 Env expressing cells by HIV -LRB- CD4/CXCR4 -RRB- vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4 .
19553524	0	CD4	33,36	Env	99,102	CD4	Env	920	30816	Gene	Gene	results|nummod|START_ENTITY Expression|nmod|results Expression|acl|derived derived|nmod|sequence sequence|compound|END_ENTITY	Expression of a modified form of CD4 results in the release of an anti-HIV factor derived from the Env sequence .
23824793	0	CD4	0,3	Env	65,68	CD4	Env	920	30816	Gene	Gene	cells|compound|START_ENTITY support|nsubj|cells support|dobj|production production|nmod|antibodies antibodies|compound|END_ENTITY	CD4 + T cells support production of simian_immunodeficiency_virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo .
24156704	0	CD4	16,19	Env	65,68	CD4	Env	920	30816	Gene	Gene	T-cells|compound|START_ENTITY increase|nsubj|T-cells increase|xcomp|END_ENTITY	GagPol-specific CD4 T-cells increase the antibody response to Env by intrastructural help .
26764036	0	CD4	73,76	Env	6,9	CD4	Env	920	100616444	Gene	Gene	Loss|compound|START_ENTITY along|nmod|Loss Phenotype|advmod|along Phenotype|nsubj|Glycoprotein Glycoprotein|compound|END_ENTITY	HIV-1 Env Glycoprotein Phenotype along with Immune Activation Determines CD4 T Cell Loss in HIV Patients .
27026376	0	CD4	72,75	Env	28,31	CD4	Env	920	155971(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY depletion|nmod|cells contributes|nmod|depletion contributes|nsubj|interaction interaction|nmod|END_ENTITY	CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo .
9049413	0	CD4	21,24	Env	81,84	CD4	Env	920	155971(Tax:11676)	Gene	Gene	START_ENTITY|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Rapid degradation of CD4 in cells expressing human_immunodeficiency_virus_type_1 Env and Vpu is blocked by proteasome inhibitors .
15466453	0	CD4	68,71	FOXP3	16,21	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells role|nmod|development role|nmod|END_ENTITY	Crucial role of FOXP3 in the development and function of human CD25 + CD4 + regulatory T cells .
15620457	0	CD4	44,47	FOXP3	14,19	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY confined|nmod|cells confined|nsubjpass|Expression Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of FOXP3 mRNA is not confined to CD4 + CD25 + T regulatory cells in humans .
15902688	0	CD4	46,49	FOXP3	12,17	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 expression|compound|END_ENTITY	Analysis of FOXP3 protein expression in human CD4 + CD25 + regulatory T cells at the single-cell level .
15972448	0	CD4	28,31	FOXP3	21,26	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Reduced frequency of FOXP3 + CD4 + CD25 + regulatory T cells in patients with chronic_graft-versus-host_disease .
16211090	0	CD4	56,59	FOXP3	14,19	CD4	FOXP3	920	50943	Gene	Gene	Tregs|compound|START_ENTITY generation|nmod|Tregs isoforms|nmod|generation isoforms|nsubj|role role|nmod|END_ENTITY	The role of 2 FOXP3 isoforms in the generation of human CD4 + Tregs .
16339542	0	CD4	118,121	FOXP3	109,114	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|dobj|capacity capacity|nmod|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16339542	0	CD4	6,9	FOXP3	109,114	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|ccomp|enhances enhances|dobj|capacity capacity|nmod|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16585024	0	CD4	63,66	FOXP3	54,59	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Expression of the putatively regulatory T-cell marker FOXP3 by CD4 -LRB- + -RRB- CD25 + T cells after pediatric hematopoietic stem cell transplantation .
16645171	0	CD4	41,44	FOXP3	15,20	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16764698	0	CD4	39,42	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY identifies|dobj|cells identifies|nsubj|END_ENTITY	FOXP3 identifies regulatory CD25bright CD4 + T cells in rheumatic_joints .
16785520	0	CD4	6,9	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	FOXP3 + CD4 + CD25 + adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin_E2-dependent mechanism .
17005002	0	CD4	66,69	FOXP3	25,30	CD4	FOXP3	920	50943	Gene	Gene	activation|compound|START_ENTITY inhibitors|nmod|activation functional|dobj|inhibitors functional|nsubj|variants variants|nmod|END_ENTITY	Splice variants of human FOXP3 are functional inhibitors of human CD4 + T-cell activation .
17082609	0	CD4	27,30	FOXP3	59,64	CD4	FOXP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|acl|enriched enriched|nmod|regulatory regulatory|compound|END_ENTITY	CCR8 expression identifies CD4 memory T cells enriched for FOXP3 + regulatory and Th2 effector lymphocytes .
17142730	0	CD4	43,46	FOXP3	52,57	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients .
17154262	0	CD4	63,66	FOXP3	24,29	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Transient expression of FOXP3 in human activated nonregulatory CD4 + T cells .
17178393	0	CD4	56,59	FOXP3	61,66	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 blockade promotes the expansion of antigen-specific CD4 + FOXP3 + regulatory T cells in vivo .
17198560	0	CD4	27,30	FOXP3	13,18	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY mRNA|nmod|cells mRNA|compound|END_ENTITY	-LSB- Decrease of FOXP3 mRNA in CD4 + T cells in latent_autoimmune_diabetes_in_adult -RSB- .
17296785	0	CD4	55,58	FOXP3	68,73	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY activity|nmod|CD25 activity|dep|END_ENTITY	WASP regulates suppressor activity of human and murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- natural regulatory T cells .
17463169	0	CD4	10,13	FOXP3	21,26	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic_anemia .
17478450	0	CD4	76,79	FOXP3	58,63	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses .
17582431	0	CD4	61,64	FOXP3	70,75	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flow cytometry-based methods for studying signaling in human CD4 + CD25 + FOXP3 + T regulatory cells .
17644734	0	CD4	45,48	FOXP3	13,18	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Induction of FOXP3 expression in naive human CD4 + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype .
17644734	0	CD4	45,48	FOXP3	49,54	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction of FOXP3 expression in naive human CD4 + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype .
17671219	0	CD4	40,43	FOXP3	44,49	CD4	FOXP3	920	50943	Gene	Gene	pool|compound|START_ENTITY pool|compound|END_ENTITY	Interleukin-2 administration alters the CD4 + FOXP3 + T-cell pool and tumor trafficking in patients with ovarian_carcinoma .
17916446	0	CD4	42,45	FOXP3	109,114	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY changes|nmod|CD25 +|nsubj|changes +|nmod|patients patients|nmod|mutations mutations|compound|END_ENTITY	Developmental changes of FOXP3-expressing CD4 + CD25 + regulatory T cells and their impairment in patients with FOXP3 gene mutations .
17982112	0	CD4	25,28	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|nummod|expressing expressing|compound|END_ENTITY	FOXP3 expressing CD127lo CD4 + T cells inversely correlate with CD38 + CD8 + T cell activation levels in primary HIV-1_infection .
17984976	0	CD4	38,41	FOXP3	102,107	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY Generation|nmod|+ T|nsubj|Generation T|nmod|expression expression|nmod|END_ENTITY	Generation of potent and stable human CD4 + T regulatory cells by activation-independent expression of FOXP3 .
18025205	0	CD4	17,20	FOXP3	26,31	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18173798	0	CD4	20,23	FOXP3	25,30	CD4	FOXP3	920	50943	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Characterization of CD4 + FOXP3 + T-cell clones established from chronic inflammatory lesions .
18180044	0	CD4	55,58	FOXP3	18,23	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 END_ENTITY|nmod|expression	Cloning of feline FOXP3 and detection of expression in CD4 + CD25 + regulatory T cells .
18270250	0	CD4	25,28	FOXP3	52,57	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18270368	0	CD4	62,65	FOXP3	53,58	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY regulate|nmod|CD25 regulate|dobj|expression expression|nmod|END_ENTITY	STAT5-signaling cytokines regulate the expression of FOXP3 in CD4 + CD25 + regulatory T cells and CD4 + CD25 - effector T cells .
18287134	0	CD4	0,3	FOXP3	9,14	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + FOXP3 + T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple_myeloma following allogeneic stem cell transplantation .
18295349	0	CD4	75,78	FOXP3	84,89	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Matured human monocyte-derived dendritic cells -LRB- MoDCs -RRB- induce expansion of CD4 + CD25 + FOXP3 + T cells lacking regulatory properties .
18308639	0	CD4	70,73	FOXP3	79,84	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGFbeta1_deficiency does not affect the generation and maintenance of CD4 + CD25 + FOXP3 + putative Treg cells , but causes their numerical inadequacy and loss of regulatory function .
18313267	0	CD4	71,74	FOXP3	84,89	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY induction|nmod|CD25 induction|dep|T T|compound|END_ENTITY	Combination of rapamycin and IL-2 increases de novo induction of human CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cells .
18331536	0	CD4	25,28	FOXP3	76,81	CD4	FOXP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells circulating|nmod|cells cells|compound|END_ENTITY	Decreases in circulating CD4 + CD25hiFOXP3 + cells and increases in intragraft FOXP3 + cells accompany allograft rejection in pediatric liver allograft recipients .
18360256	0	CD4	37,40	FOXP3	46,51	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY drugs|nmod|+ Impact|nmod|drugs +|dep|Impact +|compound|END_ENTITY	Impact of immunosuppressive drugs on CD4 + CD25 + FOXP3 + regulatory T cells : does in vitro evidence translate to the clinical setting ?
18481388	0	CD4	34,37	FOXP3	27,32	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|reduction reduction|nmod|END_ENTITY	Partial reduction of human FOXP3 + CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration .
18489537	0	CD4	38,41	FOXP3	116,121	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY depletion|nmod|+ T|nsubj|depletion T|nmod|mutation mutation|compound|END_ENTITY	A remarkable depletion of both na ve CD4 + and CD8 + with high proportion of memory T cells in an IPEX infant with a FOXP3 mutation in the forkhead domain .
18493981	0	CD4	34,37	FOXP3	66,71	CD4	FOXP3	920	50943	Gene	Gene	cells|amod|START_ENTITY inducer|nmod|cells expressing|nsubj|inducer expressing|dobj|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
18497513	0	CD4	82,85	FOXP3	18,23	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY conversion|nmod|CD25 +|nmod|conversion +|dobj|Cells Cells|nummod|+ +|compound|END_ENTITY	Increased CD4CD25 + FOXP3 + regulatory T Cells in cancer patients from conversion of CD4 + CD25 - T cells through tumor-derived factors .
18504453	0	CD4	27,30	FOXP3	4,9	CD4	FOXP3	920	50943	Gene	Gene	thymocytes|compound|START_ENTITY subset|nmod|thymocytes subset|compound|END_ENTITY	The FOXP3 + subset of human CD4 + CD8 + thymocytes is immature and subject to intrathymic selection .
18508492	0	CD4	9,12	FOXP3	24,29	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|Tregs Tregs|compound|END_ENTITY	Roles of CD4 + CD25 -LRB- high -RRB- FOXP3 + Tregs in lymphomas and tumors are complex .
18606654	0	CD4	83,86	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY phenotype|nmod|CD25 regulates|dobj|phenotype regulates|nsubj|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
18829063	0	CD4	34,37	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY HIV-1_infection|nmod|T-cells inhibits|dobj|HIV-1_infection inhibits|nsubj|END_ENTITY	FOXP3 inhibits HIV-1_infection of CD4 T-cells via inhibition of LTR transcriptional activity .
18981158	0	CD4	74,77	FOXP3	79,84	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The effector T cells of diabetic subjects are resistant to regulation via CD4 + FOXP3 + regulatory T cells .
19089812	0	CD4	36,39	FOXP3	41,46	CD4	FOXP3	920	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	High frequency and proliferation of CD4 + FOXP3 + Treg in HIV-1-infected patients with low CD4 counts .
19089812	0	CD4	89,92	FOXP3	41,46	CD4	FOXP3	920	50943	Gene	Gene	patients|nmod|START_ENTITY Treg|nmod|patients Treg|compound|END_ENTITY	High frequency and proliferation of CD4 + FOXP3 + Treg in HIV-1-infected patients with low CD4 counts .
19203731	0	CD4	9,12	FOXP3	77,82	CD4	FOXP3	920	50943	Gene	Gene	infusion|compound|START_ENTITY expand|nsubj|infusion expand|dobj|cells cells|nummod|END_ENTITY	Combined CD4 + donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3 + regulatory T cells following allogeneic hematopoietic stem cell transplantation .
19283780	0	CD4	42,45	FOXP3	8,13	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 expression|nummod|END_ENTITY	Loss of FOXP3 expression in natural human CD4 + CD25 + regulatory T cells upon repetitive in vitro stimulation .
19303058	0	CD4	96,99	FOXP3	76,81	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nummod|END_ENTITY	Correlation between the degree of immune activation , production of IL-2 and FOXP3 expression in CD4 + CD25 + T regulatory cells in HIV-1 infected persons under HAART .
19352129	0	CD4	126,129	FOXP3	130,135	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Conversion from calcineurin_inhibitor to mycophenolate_mofetil-based immunosuppression changes the frequency and phenotype of CD4 + FOXP3 + regulatory T cells .
19394278	0	CD4	21,24	FOXP3	37,42	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY frequency|nmod|CD25 Reduced|dep|frequency cells|amod|Reduced cells|compound|END_ENTITY	Reduced frequency of CD4 -LRB- + -RRB- CD25 -LRB- HIGH -RRB- FOXP3 -LRB- + -RRB- cells and diminished FOXP3 expression in patients with Common_Variable_Immunodeficiency : a link to autoimmunity ?
19596013	0	CD4	47,50	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	FOXP3 expression in hepatitis_C virus-specific CD4 + T cells during acute_hepatitis_C .
19646767	0	CD4	77,80	FOXP3	90,95	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 function|nmod|expansion function|nsubj|END_ENTITY	Glatiramer_acetate improves regulatory T-cell function by expansion of naive CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- CD31 -LRB- + -RRB- T-cells in patients with multiple_sclerosis .
19713458	0	CD4	0,3	FOXP3	4,9	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FOXP3 + regulatory T cells confer long-term regulation of factor_VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice .
19727527	0	CD4	63,66	FOXP3	76,81	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 amplifies|dobj|expansion amplifies|nmod|cells cells|amod|END_ENTITY	A glucocorticoid amplifies IL-2-induced selective expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft-versus-host_disease after allogeneic lymphocyte transplantation .
19738030	0	CD4	41,44	FOXP3	10,15	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY active|nmod|CD25 cells|amod|active cells|nsubj|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19738030	0	CD4	41,44	FOXP3	113,118	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY active|nmod|CD25 cells|amod|active cells|nmod|carriers carriers|nmod|mutations mutations|compound|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19752528	0	CD4	12,15	FOXP3	28,33	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD25 bright FOXP3 + T cells are up-regulated by biological therapies and correlate with the clinical response in psoriasis patients .
19808957	0	CD4	30,33	FOXP3	23,28	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tumor antigen-specific FOXP3 + CD4 T cells identified in human metastatic melanoma : peptide vaccination results in selective expansion of Th1-like counterparts .
19822903	0	CD4	41,44	FOXP3	127,132	CD4	FOXP3	920	50943	Gene	Gene	T|compound|START_ENTITY FOXP3|nmod|T cells|amod|FOXP3 expression|nmod|cells associated|nsubj|expression associated|dep|induction induction|nmod|T T|compound|END_ENTITY	ATG-induced expression of FOXP3 in human CD4 -LRB- + -RRB- T cells in vitro is associated with T-cell activation and not the induction of FOXP3 -LRB- + -RRB- T regulatory cells .
19822903	0	CD4	41,44	FOXP3	26,31	CD4	FOXP3	920	50943	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	ATG-induced expression of FOXP3 in human CD4 -LRB- + -RRB- T cells in vitro is associated with T-cell activation and not the induction of FOXP3 -LRB- + -RRB- T regulatory cells .
19875613	0	CD4	87,90	FOXP3	67,72	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 expression|nummod|END_ENTITY	Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T-cells of type 1 diabetic subjects .
19877016	0	CD4	66,69	FOXP3	70,75	CD4	FOXP3	920	50943	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Phenotypic analysis of human peripheral blood regulatory T cells -LRB- CD4 + FOXP3 + CD127lo / - -RRB- ex vivo and after in vitro restimulation with malaria antigens .
19957514	0	CD4	24,27	FOXP3	15,20	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	-LSB- Expression of FOXP3 in CD4 + CD39 + T cells of patients with systemic_lupus_erythematosus and dynamic observation of treatment with glucocorticoid -RSB- .
20039297	0	CD4	21,24	FOXP3	25,30	CD4	FOXP3	920	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	In vivo depletion of CD4 + FOXP3 + Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII + phagocytes .
20137305	0	CD4	77,80	FOXP3	90,95	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 induces|dobj|expansion induces|nsubj|END_ENTITY	-LSB- Combination of dexamethasone with IL-2 selectively induces the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft versus host disease . -RSB- .
20172352	0	CD4	59,62	FOXP3	72,77	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY generation|nmod|CD25 END_ENTITY|nsubj|generation	Dendritic cells and B cells cooperate in the generation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- allogeneic T cells .
20302964	0	CD4	13,16	FOXP3	27,32	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Frequency|nmod|CD25 END_ENTITY|nsubj|Frequency	Frequency of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host-disease .
20338811	0	CD4	0,3	FOXP3	4,9	CD4	FOXP3	920	50943	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + FOXP3 + regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy .
20477619	0	CD4	22,25	FOXP3	13,18	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Influence of FOXP3 on CD4 + CD25 + regulatory T cells .
20498045	0	CD4	41,44	FOXP3	50,55	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 +|nmod|expansion +|nsubj|END_ENTITY	In vivo expansion of naive and activated CD4 + CD25 + FOXP3 + regulatory T cell populations in interleukin-2-treated HIV patients .
20631311	0	CD4	56,59	FOXP3	49,54	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD30 discriminates heat_shock protein 60-induced FOXP3 + CD4 + T cells with a regulatory phenotype .
20821728	0	CD4	34,37	FOXP3	39,44	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Influenza matrix 1-specific human CD4 + FOXP3 + and FOXP3 -LRB- - -RRB- regulatory T cells can be detected long after viral clearance .
20854875	0	CD4	20,23	FOXP3	31,36	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY occurring|dobj|+ increased|dep|occurring increased|nsubjpass|cells cells|compound|END_ENTITY	Naturally occurring CD4 + CD25 + FOXP3 + T-regulatory cells are increased in chronic_myeloid_leukemia patients not in complete cytogenetic remission and can be immunosuppressive .
20858449	0	CD4	32,35	FOXP3	41,46	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating regulatory T cells -LRB- CD4 + CD25 + FOXP3 + -RRB- decrease in breast_cancer patients after vaccination with a modified MHC class II HER2/neu -LRB- AE37 -RRB- peptide .
21074227	0	CD4	105,108	FOXP3	74,79	CD4	FOXP3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY level|nmod|T-cells END_ENTITY|dobj|level	Comparative study of the plasma globulin level , CD21 -LRB- - -RRB- B-cell counts and FOXP3 mRNA expression level in CD4 -LRB- + -RRB- T-cells for different clinical stages of feline_immunodeficiency_virus infected cats .
21107346	0	CD4	37,40	FOXP3	50,55	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY regulation|nmod|CD25 Mechanisms|nmod|regulation END_ENTITY|nsubj|Mechanisms	Mechanisms of impaired regulation by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in human autoimmune_diseases .
21381018	0	CD4	7,10	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	FOXP3 + CD4 + Tregs lose suppressive potential but remain anergic during transient inflammation in human .
21437244	0	CD4	52,55	FOXP3	63,68	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracerebral human regulatory T cells : analysis of CD4 + CD25 + FOXP3 + T cells in brain_lesions and cerebrospinal fluid of multiple_sclerosis patients .
21691076	0	CD4	113,116	FOXP3	139,144	CD4	FOXP3	920	50943	Gene	Gene	Forkhead_Boxp3|compound|START_ENTITY Forkhead_Boxp3|appos|END_ENTITY	Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute_lung_injury by expanding CD4 + CD25 + Forkhead_Boxp3 -LRB- FOXP3 -RRB- + regulatory T cells and balancing anti- and pro-inflammatory factors .
21791023	0	CD4	14,17	FOXP3	36,41	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY forkhead_box_P3|nummod|+ forkhead_box_P3|appos|END_ENTITY	Expression of CD4 + forkhead_box_P3 -LRB- FOXP3 -RRB- + regulatory T cells in inflammatory_bowel_disease .
21799858	0	CD4	23,26	FOXP3	113,118	CD4	FOXP3	920	50943	Gene	Gene	Requirement|nmod|START_ENTITY +|nsubj|Requirement +|parataxis|generated generated|nsubj|cells cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21799858	0	CD4	95,98	FOXP3	113,118	CD4	FOXP3	920	50943	Gene	Gene	CD127|compound|START_ENTITY +|nmod|CD127 +|parataxis|generated generated|nsubj|cells cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21829534	0	CD4	30,33	FOXP3	129,134	CD4	FOXP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells NY-ESO-1-specific|advcl|circulating NY-ESO-1-specific|nsubj|T T|dep|cells cells|acl|undetectable undetectable|nmod|compartment compartment|compound|END_ENTITY	NY-ESO-1-specific circulating CD4 + T cells in ovarian_cancer patients are prevalently T -LRB- H -RRB- 1 type cells undetectable in the CD25 + FOXP3 + Treg compartment .
21856944	0	CD4	0,3	FOXP3	4,9	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FOXP3 + T regulatory cells in human autoimmunity : more than a numbers game .
21865550	0	CD4	54,57	FOXP3	39,44	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY promotes|nmod|cells promotes|dobj|induction induction|nmod|END_ENTITY	Low-dose antigen promotes induction of FOXP3 in human CD4 + T cells .
21897268	0	CD4	44,47	FOXP3	48,53	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immunofluorescence-detected infiltration of CD4 + FOXP3 + regulatory T cells is relevant to the prognosis of patients with endometrial_cancer .
21934066	0	CD4	118,121	FOXP3	34,39	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY fractions|nmod|cells associated|nmod|fractions associated|nsubjpass|proportions proportions|acl|circulating circulating|dobj|+ +|compound|END_ENTITY	Higher proportions of circulating FOXP3 + and CTLA-4 + regulatory T cells are associated with lower fractions of memory CD4 + T cells in infants .
21998454	0	CD4	49,52	FOXP3	131,136	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells identifies|nsubj|expression identifies|nmod|differentiation differentiation|nmod|Th17 Th17|nmod|cells cells|amod|naive naive|nmod:npmod|+ +|nummod|END_ENTITY	Ex vivo IL-1 receptor type I expression in human CD4 + T cells identifies an early intermediate in the differentiation of Th17 from FOXP3 + naive regulatory T cells .
22087344	0	CD4	13,16	FOXP3	26,31	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Induction|nmod|CD25 END_ENTITY|nsubj|Induction	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells during human hookworm_infection modulates antigen-mediated lymphocyte proliferation .
22214248	0	CD4	64,67	FOXP3	17,22	CD4	FOXP3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY function|nmod|T-cells function|nsubj|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of FOXP3 and induction of suppressive function in CD4 + Jurkat T-cells expressing hepatitis_C virus core protein .
22267598	0	CD4	126,129	FOXP3	109,114	CD4	FOXP3	920	50943	Gene	Gene	ratios|appos|START_ENTITY ratios|appos|END_ENTITY	Necrotising_enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory -LRB- FOXP3 -RRB- / effector -LRB- CD4 , CD8 -RRB- T cell ratios .
22276195	0	CD4	28,31	FOXP3	44,49	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 +|nmod|expansion +|nsubj|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22310634	0	CD4	12,15	FOXP3	25,30	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Absolute|nmod|CD25 END_ENTITY|nsubj|Absolute	Absolute of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T-cell count rather than its ratio in peripheral blood is related to long-term survival of renal allografts .
22471961	0	CD4	52,55	FOXP3	58,63	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Differential pattern and prognostic significance of CD4 + , FOXP3 + and IL-17 + tumor infiltrating lymphocytes in ductal_and_lobular_breast_cancers .
22585562	0	CD4	45,48	FOXP3	56,61	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
22586481	0	CD4	31,34	FOXP3	25,30	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interleukin-7 influences FOXP3 + CD4 + regulatory T cells peripheral homeostasis .
22670785	0	CD4	25,28	FOXP3	32,37	CD4	FOXP3	920	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripherally circulating CD4 FOXP3 CXCR3 T regulatory cells correlate with renal allograft function .
22891772	0	CD4	44,47	FOXP3	90,95	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY conversion|nmod|CD25 modulates|dobj|conversion T|dep|modulates T|nsubj|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22891772	0	CD4	71,74	FOXP3	90,95	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY T|nmod|CD25 T|nsubj|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22956260	0	CD4	70,73	FOXP3	85,90	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Skewed immunological balance between Th17 -LRB- CD4 -LRB- + -RRB- IL17A -LRB- + -RRB- -RRB- and Treg -LRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- -RRB- cells in human oral_squamous_cell_carcinoma .
23019018	0	CD4	0,3	FOXP3	56,61	CD4	FOXP3	920	50943	Gene	Gene	CD127|compound|START_ENTITY CD127|dep|assessment assessment|nmod|phenotype phenotype|nmod|cells cells|nummod|END_ENTITY	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
23019301	0	CD4	0,3	FOXP3	15,20	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 CD25 FOXP3 regulatory T cells in peripheral blood and peritoneal fluid of patients with endometriosis .
23251077	0	CD4	78,81	FOXP3	82,87	CD4	FOXP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Conditioned medium from adipose tissue-derived mesenchymal stem cells induces CD4 + FOXP3 + cells and increases IL-10 secretion .
23252864	0	CD4	16,19	FOXP3	27,32	CD4	FOXP3	920	50943	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Crucial role of CD4 + CD_25 + FOXP3 + T regulatory cell , interferon-y and interleukin-16 in malignant and tuberculous_pleural_effusions .
23340699	0	CD4	8,11	FOXP3	21,26	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lack of CD4 CD25 FOXP3 regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki_disease .
23432692	0	CD4	50,53	FOXP3	65,70	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY markers|nmod|CD25 Frequency|nmod|markers +|nsubj|Frequency +|compound|END_ENTITY	Frequency and expression of inhibitory markers of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in patients with common variable immunodeficiency .
23509755	0	CD4	0,3	FOXP3	11,16	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + FOXP3 + Treg cells induced by rSSP4 derived from T. _ cruzi amastigotes increase parasitemia in an experimental Chagas_disease model .
23964278	0	CD4	77,80	FOXP3	28,33	CD4	FOXP3	920	50943	Gene	Gene	Effectors|compound|START_ENTITY Stimulation|nmod|Effectors Induced|nmod|Stimulation T|dobj|Induced T|nsubj|Expression Expression|nmod|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
23968847	0	CD4	45,48	FOXP3	56,61	CD4	FOXP3	920	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Influences of cerebral stent implantation on CD4 + CD25 + FOXP3 + Treg , Th1 and Th17 cells .
23993302	0	CD4	83,86	FOXP3	23,28	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY occurs|nmod|CD25 occurs|nsubj|depletion depletion|nmod|cells cells|amod|END_ENTITY	Selective depletion of FOXP3 -LRB- high -RRB- cells by Fas-Fas-L-induced apoptosis occurs in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - enriched populations during repeated expansion .
24076591	0	CD4	48,51	FOXP3	57,62	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Arteether exerts antitumor activity and reduces CD4 + CD25 + FOXP3 + T-reg cells in vivo .
24244610	0	CD4	30,33	FOXP3	40,45	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24264641	0	CD4	23,26	FOXP3	34,39	CD4	FOXP3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased frequency of CD4 + CD25 + FOXP3 + cells correlates with the progression of 4-nitroquinoline1-oxide-induced rat tongue carcinogenesis .
24316592	0	CD4	80,83	FOXP3	71,76	CD4	FOXP3	920	50943	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Up-regulation of microRNA-210 induces immune_dysfunction via targeting FOXP3 in CD4 -LRB- + -RRB- T cells of psoriasis_vulgaris .
24337481	0	CD4	0,3	FOXP3	91,96	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY convert|nsubj|cells convert|nmod|transfer transfer|compound|END_ENTITY	CD4 T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer .
24338252	0	CD4	40,43	FOXP3	53,58	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Alteration in frequency and function of CD4 CD25 FOXP3 regulatory T cells in patients with immune_thrombocytopenic_purpura .
24345703	0	CD4	11,14	FOXP3	20,25	CD4	FOXP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes of CD4 + CD25 + FOXP3 + and CD8 + CD28 - regulatory T cells in non-small_cell_lung_cancer patients undergoing surgery .
24368924	0	CD4	34,37	FOXP3	43,48	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An imbalance between frequency of CD4 + CD25 + FOXP3 + regulatory T cells and CCR4 + and CCR9 + circulating helper T cells is associated with active perennial allergic_conjunctivitis .
24369813	0	CD4	0,3	FOXP3	13,18	CD4	FOXP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 CD25 FOXP3 T cells , Foxp3 gene and protein expression contribute to antiasthmatic effects of San ` ao_decoction in mice model of asthma .
24454972	0	CD4	28,31	FOXP3	42,47	CD4	FOXP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
24661230	0	CD4	0,3	FOXP3	17,22	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FOXP3 -LRB- + -RRB- regulatory T cells correlate with FEV1 in North Indian children with cystic fibrosis .
24703254	0	CD4	0,3	FOXP3	4,9	CD4	FOXP3	403931(Tax:9615)	491876(Tax:9615)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FOXP3 + cells produce IL-10 in the spleens of dogs with visceral_leishmaniasis .
24995020	0	CD4	36,39	FOXP3	53,58	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Cells|nmod|CD25 Interplay|nmod|Cells END_ENTITY|nsubj|Interplay	Interplay of T Helper 17 Cells with CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FOXP3 -LRB- + -RRB- Tregs in Regulation of Allergic_Asthma in Pediatric Patients .
25099367	0	CD4	92,95	FOXP3	0,5	CD4	FOXP3	920	50943	Gene	Gene	accumulation|nmod|START_ENTITY sign|nmod|accumulation overexpression|nmod|sign END_ENTITY|acl|overexpression	FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4 -LRB- + -RRB- T regulatory cells .
25205084	0	CD4	28,31	FOXP3	42,47	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY therapy|nmod|CD25 influence|nmod|therapy cells|dep|influence cells|dep|+ +|compound|END_ENTITY	The influence of therapy on CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in systemic_lupus_erythematosus patients : a prospective study .
25548591	1	CD4	144,147	FOXP3	157,162	CD4	FOXP3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY Induction|nmod|CD25 Rats|nmod|Induction Synovial_Inflammation|nmod|Rats END_ENTITY|nsubj|Synovial_Inflammation	Suppresses Synovial_Inflammation in Adjuvant_Arthritis Rats through Apoptosis Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T Cells .
25657686	0	CD4	52,55	FOXP3	65,70	CD4	FOXP3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY accumulation|nmod|CD25 glioma|nmod|accumulation Immunotherapy|nmod|glioma END_ENTITY|nsubj|Immunotherapy	Immunotherapy of rat glioma without accumulation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells .
25740578	0	CD4	31,34	FOXP3	45,50	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Changes|nmod|CD25 +|nsubj|Changes +|compound|END_ENTITY	Changes of Naturally Occurring CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- Regulatory T Cells in Patients With Acute_Coronary_Syndrome and the Beneficial Effects of Atorvastatin Treatment .
25950023	0	CD4	127,130	FOXP3	136,141	CD4	FOXP3	403931(Tax:9615)	491876(Tax:9615)	Gene	Gene	CELLS|compound|START_ENTITY CELLS|compound|END_ENTITY	EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4 + CD25 + FOXP3 + REGULATORY T CELLS .
26166019	0	CD4	36,39	FOXP3	45,50	CD4	FOXP3	920	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26467610	0	CD4	84,87	FOXP3	56,61	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY subsets|nmod|CD25 subsets|nsubj|usage usage|appos|expression expression|nmod|Treg Treg|compound|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
26673957	0	CD4	27,30	FOXP3	40,45	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Mechanisms|nmod|CD25 END_ENTITY|nsubj|Mechanisms	Accumulation Mechanisms of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- Regulatory T Cells in EBV-associated Gastric_Carcinoma .
26709833	0	CD4	0,3	FOXP3	4,9	CD4	FOXP3	920	50943	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	CD4 + FOXP3 + Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner_Syndrome .
26962115	0	CD4	115,118	FOXP3	119,124	CD4	FOXP3	920	50943	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
26962115	0	CD4	115,118	FOXP3	95,100	CD4	FOXP3	920	50943	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|Cells Conversion|dep|Cells Conversion|nmod|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
26962115	0	CD4	91,94	FOXP3	119,124	CD4	FOXP3	920	50943	Gene	Gene	FOXP3|compound|START_ENTITY Conversion|nmod|FOXP3 Conversion|dep|Cells Cells|nmod|Cells Cells|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
27007547	0	CD4	56,59	FOXP3	85,90	CD4	FOXP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	Healthy preterm newborns show an increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- low -RRB- FOXP3 -LRB- + -RRB- regulatory T cells with a naive phenotype and high expression of gut-homing receptors .
27036917	0	CD4	88,91	FOXP3	81,86	CD4	FOXP3	713807(Tax:9544)	574303(Tax:9544)	Gene	Gene	Cells|compound|START_ENTITY +|dobj|Cells +|nsubj|END_ENTITY	Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3 + CD4 + T Cells in the Fetal Rhesus_Macaque .
8996241	0	CD4	34,37	FasL	98,102	CD4	FasL	920	356	Gene	Gene	lymphocytes|nummod|START_ENTITY apoptosis|nmod|lymphocytes mediated|nsubjpass|apoptosis mediated|nmod|END_ENTITY	Macrophage-dependent apoptosis of CD4 + T lymphocytes from HIV-infected individuals is mediated by FasL and tumor_necrosis_factor .
7541728	0	CD4	60,63	Fas_antigen	27,38	CD4	Fas antigen	920	355	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Differential expression of Fas_antigen and Bcl-2 protein on CD4 + T cells , CD8 + T cells , and monocytes .
10203105	0	CD4	26,29	Fas_ligand	91,101	CD4	Fas ligand	920	356	Gene	Gene	proliferation|nmod|START_ENTITY proliferation|dep|role role|nmod|expression expression|compound|END_ENTITY	Abnormal proliferation of CD4 - CD8 + gammadelta + T cells with chromosome 6 anomaly : role of Fas_ligand expression in spontaneous regression of the cells .
10447713	0	CD4	33,36	Fas_ligand	95,105	CD4	Fas ligand	12504(Tax:10090)	14103(Tax:10090)	Gene	Gene	lymphocytes|nummod|START_ENTITY apoptosis|nmod|lymphocytes mediated|nsubjpass|apoptosis mediated|nmod|END_ENTITY	Increased inducible apoptosis in CD4 + T lymphocytes during polymicrobial sepsis is mediated by Fas_ligand and not endotoxin .
10794428	0	CD4	23,26	Fas_ligand	86,96	CD4	Fas ligand	920	356	Gene	Gene	cells|compound|START_ENTITY loss|nmod|cells Correlation|nmod|loss form|nsubj|Correlation form|dobj|END_ENTITY	Correlation of loss of CD4 T cells with plasma levels of both soluble form Fas -LRB- CD95 -RRB- Fas_ligand -LRB- FasL -RRB- in HIV-infected infants .
10891451	0	CD4	0,3	Fas_ligand	40,50	CD4	Fas ligand	920	356	Gene	Gene	lymphocytes|compound|START_ENTITY primed|nsubjpass|lymphocytes primed|dep|express express|dobj|END_ENTITY	CD4 T lymphocytes are primed to express Fas_ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway .
10891451	0	CD4	54,57	Fas_ligand	40,50	CD4	Fas ligand	920	356	Gene	Gene	cross-linking|compound|START_ENTITY express|nmod|cross-linking express|dobj|END_ENTITY	CD4 T lymphocytes are primed to express Fas_ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway .
11272277	0	CD4	53,56	Fas_ligand	126,136	CD4	Fas ligand	920	356	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|nmod|up-regulation up-regulation|nmod|Fas Fas|dep|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
11414736	0	CD4	89,92	Fas_ligand	46,56	CD4	Fas ligand	920	356	Gene	Gene	T|compound|START_ENTITY response|compound|T produced|nmod|response produced|nsubj|consequences consequences|nmod|END_ENTITY	Positive and negative consequences of soluble Fas_ligand produced by an antigen-specific CD4 -LRB- + -RRB- T cell response in human carcinoma immune interactions .
11435308	0	CD4	133,136	Fas_ligand	105,115	CD4	Fas ligand	920	356	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|dobj|cells	Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas_ligand double-defective CD4 -LRB- + -RRB- donor T cells : involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host_disease pathogenesis .
15124861	0	CD4	55,58	Fas_ligand	80,90	CD4	Fas ligand	920	356	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Elimination of activated but not resting primary human CD4 + and CD8 + T cells by Fas_ligand -LRB- FasL/CD95L -RRB- - expressing Killer-dendritic cells .
15588377	0	CD4	65,68	Fas_ligand	111,121	CD4	Fas ligand	920	356	Gene	Gene	CD8|compound|START_ENTITY +|nsubj|CD8 +|ccomp|express express|dobj|END_ENTITY	Intrathyroidal CD4 + T lymphocytes express high levels of Fas and CD4 + CD8 + macrophages/dendritic cells express Fas_ligand in autoimmune_thyroid_disease .
15894587	0	CD4	35,38	Fas_ligand	10,20	CD4	Fas ligand	12504(Tax:10090)	356	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Increased Fas_ligand expression of CD4 + T cells by HCV core induces T cell-dependent hepatic_inflammation .
17595676	0	CD4	51,54	Fas_ligand	20,30	CD4	Fas ligand	920	356	Gene	Gene	lymphocytes|compound|START_ENTITY regulates|nmod|lymphocytes regulates|dobj|expression expression|compound|END_ENTITY	IFN-gamma regulates Fas_ligand expression in human CD4 + T lymphocytes and controls their anti-mycobacterial cytotoxic functions .
20637014	0	CD4	85,88	Fas_ligand	55,65	CD4	Fas ligand	12504(Tax:10090)	14103(Tax:10090)	Gene	Gene	T|compound|START_ENTITY plays|nmod|T plays|nmod|END_ENTITY	Organ microenvironment plays significant roles through Fas_ligand in vaccine-induced CD4 -LRB- + -RRB- T cell dependent suppression of tumor growth at the orthotopic site .
8675212	0	CD4	43,46	Fas_ligand	18,28	CD4	Fas ligand	920	356	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	HIV-1 upregulates Fas_ligand expression in CD4 + T cells in vitro and in vivo : association with Fas-mediated apoptosis and modulation by aurintricarboxylic_acid .
9480981	0	CD4	0,3	Fas_ligand	32,42	CD4	Fas ligand	920	356	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CD4 regulates susceptibility to Fas_ligand - and tumor necrosis factor-mediated apoptosis .
9548519	0	CD4	25,28	Fas_ligand	102,112	CD4	Fas ligand	920	356	Gene	Gene	Ligation|nmod|START_ENTITY inhibits|nsubj|Ligation inhibits|nmod|level level|nmod|expression expression|compound|END_ENTITY	Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas_ligand expression .
9846574	0	CD4	65,68	Fas_ligand	26,36	CD4	Fas ligand	920	356	Gene	Gene	cells|compound|START_ENTITY arrest|nmod|cells discovered|nmod|arrest discovered|nmod|END_ENTITY	Newly discovered role for Fas_ligand in the cell-cycle arrest of CD4 + T cells .
12874208	0	CD4	84,87	FoxP3	9,14	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	function|compound|START_ENTITY regulation|nmod|function controls|nmod|regulation controls|nsubj|Scurfin Scurfin|appos|END_ENTITY	Scurfin -LRB- FoxP3 -RRB- controls T-dependent immune responses in vivo through regulation of CD4 + T cell effector function .
14597769	0	CD4	80,83	FoxP3	13,18	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY activity|nmod|CD25 Induction|nmod|activity Induction|nmod|END_ENTITY	Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4 + CD25 - T cells .
15374887	0	CD4	11,14	FoxP3	65,70	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|T T|acl:relcl|express express|dobj|protein protein|amod|END_ENTITY	Cord blood CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function .
15837817	0	CD4	70,73	FoxP3	38,43	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY coexpressing|dobj|cells shows|xcomp|coexpressing shows|dobj|END_ENTITY	Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes .
16045746	0	CD4	8,11	FoxP3	0,5	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY T|nsubj|CD25 T|nsubj|END_ENTITY	FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn 's _ disease .
16252254	0	CD4	121,124	FoxP3	125,130	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dehydroepiandrosterone replacement in patients with Addison 's _ disease has a bimodal effect on regulatory -LRB- CD4 + CD25hi and CD4 + FoxP3 + -RRB- T cells .
16259008	0	CD4	41,44	FoxP3	50,55	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Genetic control of thymic development of CD4 + CD25 + FoxP3 + regulatory T lymphocytes .
16285010	0	CD4	68,71	FoxP3	22,27	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY balance|nmod|activation controls|dobj|balance controls|nsubj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Dynamic regulation of FoxP3 expression controls the balance between CD4 + T cell activation and cell death .
16410445	0	CD4	38,41	FoxP3	51,56	CD4	FoxP3	920	50943	Gene	Gene	naive|dep|START_ENTITY CD25high|amod|naive expansion|nmod|CD25high +|nmod|expansion +|nsubj|END_ENTITY	In vivo peripheral expansion of naive CD4 + CD25high FoxP3 + regulatory T cells in patients with multiple_myeloma .
16841298	0	CD4	72,75	FoxP3	64,69	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|amod|END_ENTITY	Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells in vivo and enhances their capacity to suppress EAE .
17011048	0	CD4	0,3	FoxP3	9,14	CD4	FoxP3	920	50943	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|amod|END_ENTITY	CD4 + CD25 + FoxP3 + T lymphocytes fail to suppress myelin_basic_protein-induced proliferation in patients with multiple_sclerosis .
17234458	0	CD4	0,3	FoxP3	13,18	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress Mycobacterium_tuberculosis immunity in patients with active disease .
17234458	4	CD4	622,625	FoxP3	635,640	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY number|nmod|CD25 END_ENTITY|nsubj|number	Our results indicate that the number of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- Treg increases in the blood or at the site of infection in active TB patients .
17315190	0	CD4	0,3	FoxP3	4,9	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FoxP3 + regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo .
17351648	0	CD4	86,89	FoxP3	97,102	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , not cyclosporine , permits thymic generation and peripheral preservation of CD4 + CD25 + FoxP3 + T cells .
17412560	0	CD4	41,44	FoxP3	125,130	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Converting|dobj|START_ENTITY Converting|advcl|producing producing|dobj|cells cells|nmod|transduction transduction|amod|END_ENTITY	Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction .
17621372	0	CD4	30,33	FoxP3	39,44	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17675459	0	CD4	94,97	FoxP3	79,84	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Cutting edge : trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4 + CD25 T cells .
17675460	0	CD4	76,79	FoxP3	69,74	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY expand|dobj|cells expand|iobj|END_ENTITY	Cutting edge : primary B lymphocytes preferentially expand allogeneic FoxP3 + CD4 T cells .
17675474	0	CD4	19,22	FoxP3	13,18	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction of FoxP3 + CD4 +25 + regulatory T cells following hemopoietic stem cell transplantation : role of bone marrow-derived facilitating cells .
17786278	0	CD4	39,42	FoxP3	91,96	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY alanyl-aminopeptidase|nmod|+ T-cells|amod|alanyl-aminopeptidase Inhibition|nmod|T-cells enhances|nsubj|Inhibition enhances|dobj|expression expression|nmod|END_ENTITY	Inhibition of alanyl-aminopeptidase on CD4 + CD25 + regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute_colitis in mice .
17898053	0	CD4	133,136	FoxP3	0,5	CD4	FoxP3	920	50943	Gene	Gene	activation|compound|START_ENTITY macaques|nmod|activation macaques|nsubj|T-cell T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
18025172	0	CD4	21,24	FoxP3	30,35	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2_and_4-1BB signaling .
18171284	0	CD4	32,35	FoxP3	26,31	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Functional suppression by FoxP3 + CD4 + CD25 -LRB- high -RRB- regulatory T cells during acute hepatitis_C_virus infection .
18453563	0	CD4	82,85	FoxP3	91,96	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
18457820	0	CD4	19,22	FoxP3	13,18	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Induction of FoxP3 + CD4 + CD25 + regulatory T cells by a bone marrow population distinct from plasmacytoid-DC .
18469093	0	CD4	89,92	FoxP3	98,103	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
18587005	0	CD4	0,3	FoxP3	9,14	CD4	FoxP3	404704(Tax:9823)	444998(Tax:9823)	Gene	Gene	PD1|compound|START_ENTITY PD1|compound|END_ENTITY	CD4 + CD25 + FoxP3 + PD1 - regulatory T cells in acute and stable relapsing-remitting multiple_sclerosis and their modulation by therapy .
18641318	0	CD4	63,66	FoxP3	68,73	CD4	FoxP3	920	50943	Gene	Gene	homeostasis|compound|START_ENTITY homeostasis|compound|END_ENTITY	CTLA4 expression is an indicator and regulator of steady-state CD4 + FoxP3 + T cell homeostasis .
19111574	0	CD4	18,21	FoxP3	12,17	CD4	FoxP3	920	50943	Gene	Gene	Tregs|compound|START_ENTITY +|dobj|Tregs +|nsubj|role role|nmod|END_ENTITY	The role of FoxP3 + CD4 + CD25hi Tregs in the pathogenesis of myasthenia_gravis .
19133978	0	CD4	0,3	FoxP3	13,18	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19133978	0	CD4	68,71	FoxP3	13,18	CD4	FoxP3	920	50943	Gene	Gene	increased|dobj|START_ENTITY increased|dep|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19193737	0	CD4	53,56	FoxP3	68,73	CD4	FoxP3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	End-stage_renal_failure and regulatory activities of CD4 + CD25bright + FoxP3 + T-cells .
19249569	0	CD4	37,40	FoxP3	51,56	CD4	FoxP3	100303658(Tax:9555)	101018460	Gene	Gene	CD25|compound|START_ENTITY enrichment|nmod|CD25 enrichment|acl:relcl|T T|nsubj|END_ENTITY	Rapamycin promotes the enrichment of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- FoxP3 -LRB- + -RRB- T regulatory cells from na ve CD4 -LRB- + -RRB- T cells of baboon that suppress antiporcine xenogenic response in vitro .
19249569	0	CD4	91,94	FoxP3	51,56	CD4	FoxP3	100303658(Tax:9555)	101018460	Gene	Gene	T|compound|START_ENTITY na|dobj|T T|advcl|na T|nsubj|END_ENTITY	Rapamycin promotes the enrichment of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- FoxP3 -LRB- + -RRB- T regulatory cells from na ve CD4 -LRB- + -RRB- T cells of baboon that suppress antiporcine xenogenic response in vitro .
19277040	0	CD4	34,37	FoxP3	43,48	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
19363449	0	CD4	0,3	FoxP3	33,38	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|acl|expressing expressing|dobj|END_ENTITY	CD4 + and CD8 + T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy .
19453998	0	CD4	44,47	FoxP3	53,58	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Monotherapy rapamycin allows an increase of CD4 CD25 FoxP3 T cells in renal recipients .
19464196	0	CD4	61,64	FoxP3	89,94	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY delineation|nmod|cells delineation|acl|expressing expressing|dobj|factor factor|amod|END_ENTITY	Functional delineation and differentiation dynamics of human CD4 + T cells expressing the FoxP3 transcription factor .
19557878	0	CD4	58,61	FoxP3	71,76	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY induction|nmod|CD25 favors|dobj|induction favors|nmod|cells cells|amod|END_ENTITY	Low-dose of tacrolimus favors the induction of functional CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells in solid-organ transplantation .
19604307	0	CD4	43,46	FoxP3	48,53	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY response|nummod|+ response|compound|END_ENTITY	Depletion of gammadelta + _ T cells increases CD4 + FoxP3 -LRB- T regulatory -RRB- cell response in coxsackievirus B3-induced myocarditis .
19684083	0	CD4	45,48	FoxP3	39,44	CD4	FoxP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|expansion expansion|nmod|END_ENTITY	Direct expansion of human allospecific FoxP3 + CD4 + regulatory T cells with allogeneic B cells for therapeutic application .
19833887	0	CD4	56,59	FoxP3	50,55	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Idd9 .1 locus controls the suppressive activity of FoxP3 + CD4 + CD25 + regulatory T-cells .
19845758	0	CD4	111,114	FoxP3	85,90	CD4	FoxP3	920	50943	Gene	Gene	CD25high|compound|START_ENTITY induced|nmod|CD25high induced|dobj|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	The NF-kappaB signalling pathway is involved in the LPS/IL -2 - induced upregulation of FoxP3 expression in human CD4 + CD25high regulatory T cells .
19855964	0	CD4	35,38	FoxP3	26,31	CD4	FoxP3	920	50943	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Homeostasis of peripheral FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells in patients with early and late stage breast_cancer .
20070404	0	CD4	13,16	FoxP3	26,31	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Expansion|nmod|CD25 END_ENTITY|nsubj|Expansion	Expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells in hepatitis_C virus-related chronic_hepatitis , cirrhosis and hepatocellular_carcinoma .
20096404	0	CD4	20,23	FoxP3	38,43	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	Regulatory T cells -LRB- CD4 -LRB- + -RRB- CD25 -LRB- bright -RRB- FoxP3 -LRB- + -RRB- -RRB- expansion in systemic_sclerosis correlates with disease activity and severity .
20139172	0	CD4	80,83	FoxP3	89,94	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
20173391	0	CD4	27,30	FoxP3	31,36	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20525892	0	CD4	106,109	FoxP3	110,115	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	CD4	106,109	FoxP3	60,65	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|resistance resistance|nmod|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	CD4	56,59	FoxP3	110,115	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY resistance|nmod|FoxP3 induces|dobj|resistance induces|nmod|cells cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20628341	0	CD4	24,27	FoxP3	28,33	CD4	FoxP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Decreased percentage of CD4 + FoxP3 + cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis_obliterans_syndrome .
21030463	0	CD4	7,10	FoxP3	0,5	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	FoxP3 + CD4 + T cells in systemic autoimmune_diseases : the delicate balance between true regulatory T cells and effector Th-17 cells .
21244371	0	CD4	100,103	FoxP3	109,114	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibitor of PI3Ky ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4 + CD25 + FoxP3 + regulatory T cells .
21251981	0	CD4	47,50	FoxP3	66,71	CD4	FoxP3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY induce|dobj|CD25 induce|nmod|cells cells|amod|END_ENTITY	Soluble donor-like MHC class I proteins induce CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD8 -LRB- - -RRB- FoxP3 -LRB- + -RRB- cells with potential to ameliorate graft chronic injury .
21437674	0	CD4	94,97	FoxP3	98,103	CD4	FoxP3	920	50943	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation , increases CD4 + FoxP3 + Treg cell population and prevents signs of experimental_autoimmune_encephalomyelitis in mice .
21463298	0	CD4	5,8	FoxP3	10,15	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Both CD4 + FoxP3 + and CD4 + FoxP3 - T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro .
21463298	0	CD4	5,8	FoxP3	26,31	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Both CD4 + FoxP3 + and CD4 + FoxP3 - T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro .
21469091	0	CD4	83,86	FoxP3	76,81	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3 + CD4 + T cells with limited suppressor activity .
21496498	0	CD4	56,59	FoxP3	61,66	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Stimulation-dependent induction of CD154 on a subset of CD4 + FoxP3 + T-regulatory cells .
21631498	0	CD4	99,102	FoxP3	106,111	CD4	FoxP3	920	50943	Gene	Gene	expression|nmod|START_ENTITY consequences|nmod|expression END_ENTITY|nsubj|consequences	The phenotypic and functional consequences of tumour_necrosis_factor_receptor_type_2 expression on CD4 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21635972	0	CD4	55,58	FoxP3	59,64	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Resolving the identity myth : key markers of functional CD4 + FoxP3 + regulatory T cells .
21700344	0	CD4	0,3	FoxP3	29,34	CD4	FoxP3	100052502(Tax:9796)	100052226(Tax:9796)	Gene	Gene	cells|compound|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	CD4 + CD25 + T cells expressing FoxP3 in Icelandic horses affected with insect_bite_hypersensitivity .
21824530	0	CD4	82,85	FoxP3	93,98	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4 + CD25 + FoxP3 + T reg cells in vivo .
22169715	0	CD4	0,3	FoxP3	15,20	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T regulatory cells in subjects responsive or unresponsive to hepatitis_B vaccination .
22373353	0	CD4	0,3	FoxP3	15,20	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress cytotoxicity of CD8 -LRB- + -RRB- effector T cells : implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level .
22457273	0	CD4	118,121	FoxP3	50,55	CD4	FoxP3	920	50943	Gene	Gene	repopulation|compound|START_ENTITY patients|nmod|repopulation cells|nmod|patients cells|compound|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22457273	0	CD4	36,39	FoxP3	50,55	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY cells|nummod|CD25 cells|compound|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22510013	0	CD4	34,37	FoxP3	48,53	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The frequency of peripheral blood CD4 + CD25high FoxP3 + and CD4 + CD25 - FoxP3 + regulatory T cells in normal pregnancy and pre-eclampsia .
22510013	0	CD4	34,37	FoxP3	70,75	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY frequency|nmod|+ frequency|dep|cells cells|amod|END_ENTITY	The frequency of peripheral blood CD4 + CD25high FoxP3 + and CD4 + CD25 - FoxP3 + regulatory T cells in normal pregnancy and pre-eclampsia .
22522779	0	CD4	50,53	FoxP3	65,70	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY levels|nmod|CD25 grafts|nmod|levels grafts|dobj|END_ENTITY	Allogeneic bone marrow grafts with high levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells can lead to engraftment failure .
22628434	0	CD4	26,29	FoxP3	30,35	CD4	FoxP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Low levels of circulating CD4 + FoxP3 + T cells are associated with an increased risk for development of myocardial_infarction but not for stroke .
22647666	0	CD4	54,57	FoxP3	48,53	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	HTLV-1 modulates the frequency and phenotype of FoxP3 + CD4 + T cells in virus-infected individuals .
22716916	0	CD4	0,3	FoxP3	11,16	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|parataxis|predominant predominant|nsubj|cells cells|amod|END_ENTITY	CD4 + CD25 - FoxP3 + regulatory cells are the predominant responding regulatory T cells after human rotavirus_infection or vaccination in gnotobiotic pigs .
22760780	0	CD4	20,23	FoxP3	29,34	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral_deficiency and thrombocytopenia in a murine model of immune_thrombocytopenia .
22793523	0	CD4	14,17	FoxP3	24,29	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nummod|+	The decreased CD4 + CD25 + FoxP3 + T cells in nonstimulated allergic_rhinitis patients sensitized to house dust mites .
22870329	0	CD4	60,63	FoxP3	83,88	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY conversion|nmod|cells inhibits|dobj|conversion inhibits|nmod|cells cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22870329	0	CD4	78,81	FoxP3	83,88	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22871805	0	CD4	20,23	FoxP3	0,5	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	FoxP3 regulatory CD4 T cells control the generation of functional CD8 memory .
22891289	0	CD4	124,127	FoxP3	106,111	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY CD25-FoxP3|nummod|+ Tregs|nmod|CD25-FoxP3 Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891289	0	CD4	97,100	FoxP3	106,111	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
23019895	0	CD4	49,52	FoxP3	62,67	CD4	FoxP3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Regulation effect of scorpio and scolopendra on CD4 + CD25 + FoxP3 + Treg cell in peripheral blood from rats with collagen-induced_arthritis -LRB- CIA -RRB- -RSB- .
23124877	0	CD4	20,23	FoxP3	25,30	CD4	FoxP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Flt3_ligand expands CD4 + FoxP3 + regulatory T cells in human subjects .
23241113	0	CD4	39,42	FoxP3	138,143	CD4	FoxP3	920	50943	Gene	Gene	CD25highCD127low|compound|START_ENTITY cells|dep|CD25highCD127low pathogenesis|dep|cells pathogenesis|dobj|relevance relevance|nmod|expressions expressions|compound|END_ENTITY	Phenotypic characterization of ex vivo CD4 + CD25highCD127low immune regulatory T cells in allergic_asthma : pathogenesis relevance of their FoxP3 , GITR , CTLA-4 and FAS expressions .
23365580	0	CD4	11,14	FoxP3	46,51	CD4	FoxP3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY Changes|nmod|CD25 Changes|dep|Cells Cells|appos|END_ENTITY	Changes of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Regulatory T Cells , FoxP3 in Adjuvant_Arthritis Rats with Damage of Pulmonary Function and Effects of Tripterygium_Glycosides Tablet .
23499512	0	CD4	56,59	FoxP3	72,77	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY agents|nmod|CD25 Influence|nmod|agents END_ENTITY|amod|Influence	Influence of pharmacological immunomodulatory agents on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T regulatory cells in humans .
23502334	0	CD4	17,20	FoxP3	28,33	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Sclareol reduces CD4 + CD25 + FoxP3 + Treg cells in a breast_cancer model in vivo .
23628056	0	CD4	19,22	FoxP3	12,17	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Changes|appos|CD25 Changes|nmod|END_ENTITY	-LSB- Changes of FoxP3 , CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , TLR2 and TLR9 in children with infectious_mononucleosis -RSB- .
23700559	0	CD4	28,31	FoxP3	43,48	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Number|nmod|CD25 Evaluation|nmod|Number END_ENTITY|nsubj|Evaluation	Evaluation of The Number of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- Treg Cells in Normal Mice Exposed to AFB1 and Treated with Aged Garlic Extract .
23769052	0	CD4	46,49	FoxP3	61,66	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY induction|nmod|CD25 Differences|nmod|induction cells|amod|Differences cells|amod|END_ENTITY	Differences in the induction of induced human CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T-regulatory cells and CD3 -LRB- + -RRB- CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- T-suppressor cells subset phenotypes in vitro : comparison of phorbol_12-myristate_13-acetate / ionomycin and phytohemagglutinin stimulation .
23911408	0	CD4	0,3	FoxP3	33,38	CD4	FoxP3	920	50943	Gene	Gene	T|compound|START_ENTITY regs|nsubj|T regs|advcl|associated associated|nsubjpass|END_ENTITY	CD4 + CD25 + T regs with acetylated FoxP3 are associated with immune suppression in human leprosy .
23968502	0	CD4	32,35	FoxP3	63,68	CD4	FoxP3	920	50943	Gene	Gene	types|nmod|START_ENTITY Imbalance|nmod|types forkhead|nsubj|Imbalance forkhead|dobj|protein protein|acl:relcl|T T|nsubj|3 3|appos|END_ENTITY	Imbalance of different types of CD4 -LRB- + -RRB- forkhead box protein 3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells in patients with new-onset systemic_lupus_erythematosus .
24127572	0	CD4	55,58	FoxP3	49,54	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Anti-CCR4 mAb selectively depletes effector-type FoxP3 + CD4 + regulatory T cells , evoking antitumor immune responses in humans .
24214631	0	CD4	38,41	FoxP3	0,5	CD4	FoxP3	920	50943	Gene	Gene	cells|nummod|START_ENTITY provides|nmod|cells provides|nsubj|END_ENTITY	FoxP3 provides competitive fitness to CD4 CD25 T cells in leprosy patients via transcriptional regulation .
24354800	0	CD4	33,36	FoxP3	52,57	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY ratio|nmod|CD25 END_ENTITY|nsubj|ratio	Critical stoichiometric ratio of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells and CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- responder T cells influence immunosuppression in patients with B-cell_acute_lymphoblastic_leukaemia .
24372806	0	CD4	39,42	FoxP3	57,62	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY B|nmod|CD25 Effect|nmod|B END_ENTITY|nsubj|Effect	Effect of narrow band-ultraviolet B on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T-lymphocytes in the peripheral blood of vitiligo patients .
24396417	0	CD4	0,3	FoxP3	13,18	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells and cytokines interact with estradiol in cases of missed_abortion .
24405386	0	CD4	59,62	FoxP3	68,73	CD4	FoxP3	920	50943	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Human adipose-derived stromal/stem cells induce functional CD4 + CD25 + FoxP3 + CD127 - regulatory T cells under low oxygen culture conditions .
24476849	0	CD4	18,21	FoxP3	27,32	CD4	FoxP3	403931(Tax:9615)	491876(Tax:9615)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Serial changes of CD4 + CD25 + FoxP3 + regulatory T cell in canine model of sepsis induced by endotoxin .
24498995	0	CD4	102,105	FoxP3	106,111	CD4	FoxP3	920	50943	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	IL-10 promoter polymorphisms influence susceptibility to aGvHD and are associated with proportions of CD4 + FoxP3 + lymphocytes in blood after hematopoietic stem cell transplantation .
24766907	0	CD4	83,86	FoxP3	88,93	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4 + FoxP3 + regulatory T cells .
24872025	0	CD4	142,145	FoxP3	146,151	CD4	FoxP3	920	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nummod|+	Episomal expression of truncated listeriolysin_O in LmddA-LLO-E7 vaccine enhances antitumor efficacy by preferentially inducing expansions of CD4 + FoxP3 - and CD8 + T cells .
24904415	0	CD4	0,3	FoxP3	9,14	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
24904717	0	CD4	20,23	FoxP3	33,38	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY status|nmod|CD25 +|nsubj|status +|dobj|END_ENTITY	Numerical status of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- and CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- regulatory T cells in multiple_sclerosis .
25293774	0	CD4	0,3	FoxP3	109,114	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY invariant|nsubj|+ GVHD|dep|invariant GVHD|nmod|expansion expansion|nmod|+ +|amod|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25293774	0	CD4	100,103	FoxP3	109,114	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25480168	0	CD4	28,31	FoxP3	34,39	CD4	FoxP3	920	50943	Gene	Gene	TIL|compound|START_ENTITY TIL|compound|END_ENTITY	CD25 identifies a subset of CD4 FoxP3 TIL that are exhausted yet prognostically favorable in human ovarian_cancer .
25499021	0	CD4	205,208	FoxP3	187,192	CD4	FoxP3	920	50943	Gene	Gene	ratio|nmod|START_ENTITY reduce|dobj|ratio reduce|iobj|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
25631159	0	CD4	50,53	FoxP3	65,70	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY levels|nmod|CD25 grafts|nmod|levels grafts|dobj|END_ENTITY	Allogeneic bone marrow grafts with high levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells can lead to engraftment failure .
25717504	1	CD4	74,77	FoxP3	78,83	CD4	FoxP3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	The peripheral pool of gut-homing CD4 + beta7 + T-cells and regulatory CD4 + FoxP3 + T-cells is maintained in Crohn 's _ disease patients with small_bowel_inflammation .
25833958	0	CD4	102,105	FoxP3	111,116	CD4	FoxP3	920	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4 + CD25 + FoxP3 + Treg .
25856405	0	CD4	29,32	FoxP3	34,39	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	The Critical Role of Induced CD4 + FoxP3 + Regulatory Cells in Suppression of Interleukin-17 Production and Attenuation of Mouse Orthotopic Lung Allograft Rejection .
25890330	0	CD4	42,45	FoxP3	57,62	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 expansion|dep|END_ENTITY	Jagged-1 is required for the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells .
26034548	0	CD4	14,17	FoxP3	25,30	CD4	FoxP3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Evaluation of CD4 + CD25 + FoxP3 + Regulatory T cells and FoxP3 and CTLA-4 gene Expression in Patients wwith Newly Diagnosed Tuberculosis in Northeast of Iran .
26124848	0	CD4	15,18	FoxP3	28,33	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Association|nmod|CD25 Association|nmod|cells cells|amod|END_ENTITY	Association of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with natural course of childhood chronic immune_thrombocytopenic_purpura .
26182204	0	CD4	29,32	FoxP3	11,16	CD4	FoxP3	920	50943	Gene	Gene	Cells|compound|START_ENTITY +|dobj|Cells +|nsubj|Decline Decline|nmod|END_ENTITY	Decline of FoxP3 + Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria .
26219909	0	CD4	12,15	FoxP3	30,35	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	Circulating CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T-regulatory cells in patients with atopic_dermatitis after narrowband-ultraviolet B phototherapy .
26219909	0	CD4	12,15	FoxP3	30,35	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	Circulating CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T-regulatory cells in patients with atopic_dermatitis after narrowband-ultraviolet B phototherapy .
26270121	0	CD4	95,98	FoxP3	104,109	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Cells|nmod|CD25 Role|nmod|Cells +|nsubj|Role +|dep|Cells Cells|compound|END_ENTITY	Interleukin-28B Plays a Therapeutic Role on Mouse U14 Cervical Cancer Cells by Down-Regulating CD4 + CD25 + FoxP3 + Regulatory T Cells In Vivo .
26333292	0	CD4	12,15	FoxP3	38,43	CD4	FoxP3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Decrease|nmod|CD25 END_ENTITY|amod|Decrease	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
26429981	0	CD4	25,28	FoxP3	18,23	CD4	FoxP3	920	50943	Gene	Gene	Depletion|compound|START_ENTITY +|dobj|Depletion +|nsubj|Study Study|nmod|END_ENTITY	Phase Ia Study of FoxP3 + CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody , KW-0761 , in Cancer Patients .
26517875	0	CD4	26,29	FoxP3	37,42	CD4	FoxP3	920	50943	Gene	Gene	Controlled|compound|START_ENTITY Controlled|compound|END_ENTITY	Orally-Induced Intestinal CD4 + CD25 + FoxP3 + Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic_Reactions .
26829554	0	CD4	33,36	FoxP3	42,47	CD4	FoxP3	920	50943	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
27021296	0	CD4	27,30	FoxP3	11,16	CD4	FoxP3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
27049955	0	CD4	78,81	FoxP3	87,92	CD4	FoxP3	920	50943	Gene	Gene	Suppression|compound|START_ENTITY Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27070362	0	CD4	65,68	FoxP3	74,79	CD4	FoxP3	920	50943	Gene	Gene	CD127low|compound|START_ENTITY CD127low|compound|END_ENTITY	-LSB- The treatment by expanded ex vivo autologous regulatory T-cells CD4 + CD25 + FoxP3 + CD127low restores the balance of immune system in patients with remitting-relapsing multiple_sclerosis -RSB- .
12612578	0	CD4	47,50	Foxp3	0,5	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells programs|dep|development programs|amod|END_ENTITY	Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells .
14676299	0	CD4	25,28	Foxp3	127,132	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Conversion|nmod|CD25 Conversion|dep|cells cells|nmod|CD25 CD25|acl|+ +|nmod|induction induction|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	CD4	52,55	Foxp3	127,132	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|acl|+ +|nmod|induction induction|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15100250	0	CD4	57,60	Foxp3	83,88	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY phenotype|nmod|CD25 phenotype|dep|cells cells|nmod|induction induction|amod|END_ENTITY	Cutting edge : TGF-beta induces a regulatory phenotype in CD4 + CD25 - T cells through Foxp3 induction and down-regulation of Smad7 .
15240741	0	CD4	17,20	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expressing|dobj|CD25 END_ENTITY|xcomp|expressing	Foxp3 expressing CD4 + CD25 -LRB- high -RRB- regulatory T cells are overrepresented in human metastatic_melanoma lymph nodes and inhibit the function of infiltrating T cells .
15367216	0	CD4	49,52	Foxp3	17,22	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY induces|nmod|CD25 induces|dobj|cells cells|amod|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
15520045	0	CD4	23,26	Foxp3	11,16	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Control of Foxp3 + CD25 + CD4 + regulatory cell activation and function by dendritic cells .
15753306	0	CD4	13,16	Foxp3	0,5	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY constitute|nsubj|cells CD25|parataxis|constitute CD25|compound|END_ENTITY	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15793242	0	CD4	54,57	Foxp3	83,88	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	diabetogenic_T-cells|nmod|START_ENTITY control|nmod|diabetogenic_T-cells +|nsubj|control +|dobj|T-cells T-cells|acl|expressing expressing|dobj|END_ENTITY	In vivo control of diabetogenic_T-cells by regulatory CD4 + CD25 + T-cells expressing Foxp3 .
15851684	0	CD4	13,16	Foxp3	100,105	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Induction|nmod|CD25 +|nsubj|Induction +|nmod|activation activation|nmod|END_ENTITY	Induction of CD4 + CD25 + regulatory T cells by copolymer-I through activation of transcription factor Foxp3 .
15912097	0	CD4	40,43	Foxp3	70,75	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|nmod|transfer transfer|amod|END_ENTITY	Regulatory T cells , derived from na ve CD4 + CD25 - T cells by in vitro Foxp3 gene transfer , can induce transplantation tolerance .
16272276	0	CD4	79,82	Foxp3	86,91	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine vascular endothelium activates and induces the generation of allogeneic CD4 +25 + Foxp3 + regulatory T cells .
16478885	0	CD4	6,9	Foxp3	0,5	CD4	Foxp3	450124(Tax:9598)	740909(Tax:9598)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Foxp3 + CD4 + CD25 + T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis_C .
16670295	0	CD4	42,45	Foxp3	5,10	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	clonal|compound|START_ENTITY induction|nsubj|clonal facilitate|xcomp|induction +|ccomp|facilitate +|nsubj|END_ENTITY	CD25 + Foxp3 + regulatory T cells facilitate CD4 + T cell clonal anergy induction during the recovery from lymphopenia .
16698419	0	CD4	17,20	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Foxp3 expressing CD4 + CD25 + and CD8 + CD28 - T regulatory cells in the peripheral blood of patients with lung_cancer and pleural_mesothelioma .
16709816	0	CD4	0,3	Foxp3	9,14	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T cells and CD4 + CD25-Foxp3 + T cells in aged mice .
16751356	0	CD4	25,28	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : allogeneic CD4 + CD25 + Foxp3 + T regulatory cells suppress autoimmunity while establishing transplantation tolerance .
16785516	0	CD4	54,57	Foxp3	98,103	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY overexpression|nmod|CD25 overexpression|parataxis|leads leads|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	G_protein-coupled_receptor_83 overexpression in naive CD4 + CD25 - T cells leads to the induction of Foxp3 + regulatory T cells in vivo .
16879995	0	CD4	46,49	Foxp3	40,45	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Origin and T cell receptor diversity of Foxp3 + CD4 + CD25 + T cells .
16906223	0	CD4	58,61	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Role|nmod|CD25 Role|nmod|IFN-gamma IFN-gamma|nmod|induction induction|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16906223	0	CD4	80,83	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY cells|nmod|Tregs Role|dep|cells Role|nmod|IFN-gamma IFN-gamma|nmod|induction induction|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16914538	0	CD4	70,73	Foxp3	79,84	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel mechanism of action for anti-thymocyte globulin : induction of CD4 + CD25 + Foxp3 + regulatory T cells .
16943258	0	CD4	56,59	Foxp3	65,70	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	An MHC-linked locus modulates thymic differentiation of CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
17015695	0	CD4	84,87	Foxp3	93,98	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17056509	0	CD4	26,29	Foxp3	20,25	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of Foxp3 + CD4 + CD25 + and IL-10-secreting CD4 + CD25 + T cells during cure of colitis .
17056509	2	CD4	355,358	Foxp3	349,354	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Using Foxp3 as a marker of regulatory T cell activity , we now provide a comprehensive analysis of the in vivo distribution of Foxp3 + CD4 + CD25 + cells in wild-type mice , and during cure of experimental colitis .
17079944	0	CD4	49,52	Foxp3	43,48	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|roles roles|nmod|populations populations|nmod|END_ENTITY	Clinical roles of increased populations of Foxp3 + CD4 + T cells in peripheral blood from advanced pancreatic_cancer patients .
17082572	0	CD4	92,95	Foxp3	101,106	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cyclophosphamide-induced type-1_diabetes in the NOD mouse is associated with a reduction of CD4 + CD25 + Foxp3 + regulatory T cells .
17114433	0	CD4	119,122	Foxp3	91,96	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Oral tolerance induction with antigen conjugated to cholera_toxin_B_subunit generates both Foxp3 + CD25 + and Foxp3-CD25 - CD4 + regulatory T cells .
17142726	0	CD4	20,23	Foxp3	24,29	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice .
17262084	0	CD4	30,33	Foxp3	24,29	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Increase in circulating Foxp3 + CD4 + CD25 -LRB- high -RRB- regulatory T cells in nasopharyngeal_carcinoma patients .
17277105	0	CD4	48,51	Foxp3	72,77	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17296786	0	CD4	69,72	Foxp3	82,87	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	The Wiskott-Aldrich_syndrome protein is required for the function of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
17307871	0	CD4	51,54	Foxp3	91,96	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY cells|nmod|CD25 cells|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Dendritic cells with TGF-beta1 differentiate naive CD4 + CD25 - T cells into islet-protective Foxp3 + regulatory T cells .
17309822	0	CD4	66,69	Foxp3	43,48	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY transcription|nmod|CD25 transcription|amod|END_ENTITY	Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4 + CD25 - T lymphocytes .
17311282	0	CD4	49,52	Foxp3	18,23	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 expression|amod|END_ENTITY	The regulation of Foxp3 expression in regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells : multiple pathways on the road .
17316678	0	CD4	32,35	Foxp3	41,46	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The clonal composition of human CD4 + CD25 + Foxp3 + cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements .
17339434	0	CD4	19,22	Foxp3	23,28	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Treatment-enhanced CD4 + Foxp3 + glucocorticoid-induced TNF receptor family related high regulatory tumor-infiltrating T cells limit the effectiveness of cytokine-based immunotherapy .
17350019	0	CD4	11,14	Foxp3	22,27	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells expand during experimental Plasmodium infection but do not prevent cerebral_malaria .
17371960	0	CD4	48,51	Foxp3	58,63	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Function of the IL-2R for thymic and peripheral CD4 + CD25 + Foxp3 + T regulatory cells .
17376831	0	CD4	45,48	Foxp3	38,43	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Impaired T cell receptor signaling in Foxp3 + CD4 T cells .
17389235	0	CD4	60,63	Foxp3	71,76	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17428252	0	CD4	83,86	Foxp3	94,99	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Diabetes_in_non-obese diabetic mice is not associated with quantitative changes in CD4 + CD25 + Foxp3 + regulatory T cells .
17453966	0	CD4	23,26	Foxp3	46,51	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY enriches|nmod|CD25 enriches|dobj|END_ENTITY	Rapamycin enriches for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD27 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple_sclerosis .
17473687	0	CD4	19,22	Foxp3	69,74	CD4	Foxp3	920	50943	Gene	Gene	T|compound|START_ENTITY role|nmod|T cells|nsubj|role cells|dobj|END_ENTITY	A possible role of CD4 + CD25 + T cells as well as transcription factor Foxp3 in the dysregulation of allergic_rhinitis .
17475646	0	CD4	18,21	Foxp3	11,16	CD4	Foxp3	100009152(Tax:9986)	100348270(Tax:9986)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Functional Foxp3 + CD4 + CD25 -LRB- Bright + -RRB- `` natural '' regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4 + and CD8 + effector T cells during ocular_herpes_infection .
17475784	0	CD4	73,76	Foxp3	20,25	CD4	Foxp3	920	50943	Gene	Gene	subsets|compound|START_ENTITY expression|nmod|subsets expression|amod|END_ENTITY	TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4 + T cell subsets .
17488604	0	CD4	20,23	Foxp3	13,18	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	-LSB- Analysis of Foxp3 + CD4 + CD25 + regulatory cells in peripheral blood of patients with SLE -RSB- .
17545218	0	CD4	149,152	Foxp3	96,101	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY promotes|nmod|cells promotes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17545218	0	CD4	87,90	Foxp3	96,101	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17615291	0	CD4	99,102	Foxp3	42,47	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
17641007	0	CD4	77,80	Foxp3	99,104	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY conversion|nmod|cells inhibits|dobj|conversion inhibits|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17675505	0	CD4	105,108	Foxp3	22,27	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY reveal|dobj|cells reveal|nmod|cells cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17675505	0	CD4	18,21	Foxp3	22,27	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17684039	0	CD4	69,72	Foxp3	78,83	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY graft-versus-host_disease|nmod|+ END_ENTITY|amod|graft-versus-host_disease	Blockade of chronic graft-versus-host_disease by alloantigen-induced CD4 + CD25 + Foxp3 + regulatory T cells in nonlymphopenic hosts .
17687106	0	CD4	104,107	Foxp3	113,118	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4 + CD25 + Foxp3 + regulatory T cells .
17688698	0	CD4	127,130	Foxp3	68,73	CD4	Foxp3	920	50943	Gene	Gene	CD25|nummod|START_ENTITY induction|nmod|CD25 induction|amod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
17699744	0	CD4	98,101	Foxp3	138,143	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells specialized|nmod|differentiation specialized|nmod|precursors precursors|amod|END_ENTITY	Dendritic cells are specialized accessory cells along with TGF - for the differentiation of Foxp3 + CD4 + regulatory T cells from peripheral Foxp3 precursors .
17699744	0	CD4	98,101	Foxp3	91,96	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Dendritic cells are specialized accessory cells along with TGF - for the differentiation of Foxp3 + CD4 + regulatory T cells from peripheral Foxp3 precursors .
17728327	0	CD4	20,23	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Foxp3 expression in CD4 + T cells of patients with systemic_lupus_erythematosus : a comparative phenotypic analysis .
17785774	0	CD4	36,39	Foxp3	49,54	CD4	Foxp3	920	50943	Gene	Gene	repertoire|compound|START_ENTITY repertoire|compound|END_ENTITY	Cutting edge : size and diversity of CD4 + CD25high Foxp3 + regulatory T cell repertoire in humans : evidence for similarities and partial overlapping with CD4 + CD25 - T cells .
17785792	0	CD4	53,56	Foxp3	77,82	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY transcription|nmod|cells suppression|nmod|transcription suppression|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17785792	0	CD4	73,76	Foxp3	77,82	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17875988	0	CD4	21,24	Foxp3	31,36	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|acl|+ +|dobj|cells cells|amod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD4	61,64	Foxp3	31,36	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells +|dobj|cells cells|amod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17911604	0	CD4	55,58	Foxp3	64,69	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
17967941	0	CD4	129,132	Foxp3	76,81	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY +|advcl|cells +|nsubj|impact impact|nmod|inhibition inhibition|nmod|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17982458	0	CD4	94,97	Foxp3	9,14	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells induce|dobj|apoptosis +|ccomp|induce +|nsubj|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
18025186	0	CD4	66,69	Foxp3	70,75	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Keratinocyte_growth_factor induces expansion of murine peripheral CD4 + Foxp3 + regulatory T cells and increases their thymic output .
18029395	0	CD4	126,129	Foxp3	120,125	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Essential roles of TGF-beta in anti-CD3 antibody therapy : reversal of diabetes in nonobese diabetic mice independent of Foxp3 + CD4 + regulatory T cells .
18054287	0	CD4	12,15	Foxp3	28,33	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Decrease|nmod|CD25 END_ENTITY|nsubj|Decrease	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and elevation of CD19 -LRB- + -RRB- BAFF-R -LRB- + -RRB- B cells and soluble ICAM-1 in myasthenia_gravis .
18159952	0	CD4	169,172	Foxp3	178,183	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Repeated 0.5-Gy gamma irradiation attenuates autoimmune_disease in MRL-lpr/lpr mice with suppression of CD3 + CD4-CD8-B220 + T-cell proliferation and with up-regulation of CD4 + CD25 + Foxp3 + regulatory T cells .
18256318	0	CD4	99,102	Foxp3	108,113	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Autologous bone marrow transplantation in autoimmune_arthritis restores immune homeostasis through CD4 + CD25 + Foxp3 + regulatory T cells .
18258482	0	CD4	6,9	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	immunosuppression|compound|START_ENTITY immunosuppression|compound|END_ENTITY	Foxp3 + CD4 + T cell-mediated immunosuppression involves extracellular nucleotide catabolism .
18279702	0	CD4	17,20	Foxp3	21,26	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GAD-IgG-inducing CD4 + Foxp3 + Treg cells suppressing diabetes are involved in the increasing ratio of CD80 + : CD86 + CELLS in NOD mice .
18283119	0	CD4	55,58	Foxp3	59,64	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The AKT-mTOR axis regulates de novo differentiation of CD4 + Foxp3 + cells .
18304352	0	CD4	15,18	Foxp3	24,29	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The control of CD4 + CD25 + Foxp3 + regulatory T cell survival .
18320914	0	CD4	94,97	Foxp3	76,81	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY numbers|nummod|+ interactions|dep|numbers interactions|nmod|C-260T C-260T|nmod|+ +|amod|END_ENTITY	Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3 + and Foxp3 - CD4 + lymphocyte numbers and total serum IgE levels in early childhood .
18395858	0	CD4	86,89	Foxp3	80,85	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Critical role of IL-2 and TGF-beta in generation , function and stabilization of Foxp3 + CD4 + Treg .
18412171	0	CD4	106,109	Foxp3	56,61	CD4	Foxp3	920	50943	Gene	Gene	cells|amod|START_ENTITY induce|nmod|cells induce|nsubj|overexpression overexpression|nmod|either either|nmod|isoforms isoforms|compound|END_ENTITY	Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- cells .
18431238	0	CD4	82,85	Foxp3	91,96	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depleting anti-CD4 monoclonal antibody -LRB- GK1 .5 -RRB- treatment : influence on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
18453622	0	CD4	79,82	Foxp3	88,93	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	dysfunction|compound|START_ENTITY dysfunction|compound|END_ENTITY	Development of inflammatory_bowel_disease in Long-Evans Cinnamon rats based on CD4 + CD25 + Foxp3 + regulatory T cell dysfunction .
18462346	0	CD4	58,61	Foxp3	69,74	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
18477692	0	CD4	66,69	Foxp3	75,80	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18477692	0	CD4	66,69	Foxp3	95,100	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion/differentiation|nmod|+ IL-1|nmod|expansion/differentiation END_ENTITY|amod|IL-1	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18480441	0	CD4	36,39	Foxp3	47,52	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-generated antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells control the severity of herpes simplex virus-induced ocular_immunoinflammatory_lesions .
18490709	0	CD4	20,23	Foxp3	14,19	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18493984	0	CD4	36,39	Foxp3	49,54	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY suppression|nmod|CD25 induces|nmod|suppression induces|dobj|END_ENTITY	IL-2 induces in vivo suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18503888	0	CD4	67,70	Foxp3	80,85	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY tolerance|nmod|CD25 Induction|nmod|tolerance END_ENTITY|nsubj|Induction	Induction of transplantation tolerance by allogeneic donor-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18510697	0	CD4	40,43	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Foxp3 expression on normal and leukemic CD4 + CD25 + T cells implicated in human T-cell_leukemia_virus_type-1 is inconsistent with Treg cells .
18566388	0	CD4	25,28	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18599457	0	CD4	79,82	Foxp3	73,78	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Programmed_death_1_ligand signaling regulates the generation of adaptive Foxp3 + CD4 + regulatory T cells .
18641303	0	CD4	45,48	Foxp3	104,109	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	differentiation|nummod|START_ENTITY regulates|dobj|differentiation regulates|advcl|repressing repressing|dobj|expression expression|amod|END_ENTITY	IFN regulatory factor-1 negatively regulates CD4 + CD25 + regulatory T cell differentiation by repressing Foxp3 expression .
18658093	0	CD4	18,21	Foxp3	27,32	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expanded CD4 + CD25 + Foxp3 + regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation .
18676178	0	CD4	37,40	Foxp3	29,34	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|amod|END_ENTITY	Natural and TGF-beta-induced Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells are not mirror images of each other .
18784738	0	CD4	197,200	Foxp3	201,206	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lenalidomide alone or in combination with dexamethasone is highly effective in patients with relapsed multiple_myeloma following allogeneic stem cell transplantation and increases the frequency of CD4 + Foxp3 + T cells .
18792402	0	CD4	25,28	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Resting B cells expand a CD4 + CD25 + Foxp3 + Treg population via TGF-beta3 .
18832523	0	CD4	0,3	Foxp3	4,9	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY expansion|compound|END_ENTITY	CD4 + Foxp3 + regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells .
18832672	0	CD4	84,87	Foxp3	95,100	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CD47 controls the in vivo proliferation and homeostasis of peripheral CD4 + CD25 + Foxp3 + regulatory T cells that express CD103 .
18924611	0	CD4	16,19	Foxp3	20,25	CD4	Foxp3	920	50943	Gene	Gene	accumulation|compound|START_ENTITY accumulation|compound|END_ENTITY	The kinetics of CD4 + Foxp3 + T cell accumulation during a human cutaneous antigen-specific memory response in vivo .
18930767	0	CD4	21,24	Foxp3	25,30	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vivo expansion of CD4 + Foxp3 + regulatory T cells mediated by GITR molecules .
18941219	0	CD4	46,49	Foxp3	51,56	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Impact of protective IL-2 allelic variants on CD4 + Foxp3 + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice .
18981109	0	CD4	6,9	Foxp3	17,22	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + Foxp3 + regulatory T cells do not constitutively express IL-35 .
18981295	0	CD4	76,79	Foxp3	85,90	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4 + CD25 + Foxp3 + T regulatory cells in mycobacterial_infection .
19003876	0	CD4	55,58	Foxp3	48,53	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Local accumulation and activation of regulatory Foxp3 + CD4 T -LRB- R -RRB- cells accompanies the appearance of activated CD8 T cells in the liver .
19006694	0	CD4	79,82	Foxp3	23,28	CD4	Foxp3	920	50943	Gene	Gene	Cells|compound|START_ENTITY relieving|nmod|Cells enhances|advcl|relieving enhances|dobj|induction induction|amod|END_ENTITY	Retinoic_acid enhances Foxp3 induction indirectly by relieving inhibition from CD4 + CD44hi Cells .
19019089	0	CD4	0,3	Foxp3	16,21	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|compound|CD25	CD4 + CD25 -LRB- high -RRB- Foxp3 + regulatory T cells downregulate human Vdelta2 + T-lymphocyte function triggered by anti-CD3 or phosphoantigen .
19034003	0	CD4	25,28	Foxp3	51,56	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	-LSB-|compound|START_ENTITY -LSB-|acl|corrected corrected|dobj|END_ENTITY	Pancreatic islets induce CD4 -LRB- + -RRB- -LSB- corrected -RSB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- -LSB- corrected -RSB- T-cell regulated tolerance to HY-mismatched skin grafts .
19077104	0	CD4	20,23	Foxp3	14,19	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Expression of Foxp3 + CD4 + CD25 + regulatory T cells and Th1/Th2 , Tc1/Tc2 profiles in the peripheral blood of patients with condyloma acuminatum .
19089814	0	CD4	29,32	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Early recruitment of natural CD4 + Foxp3 + Treg cells by infective larvae determines the outcome of filarial_infection .
19146957	0	CD4	51,54	Foxp3	60,65	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	The significantly enhanced frequency of functional CD4 + CD25 + Foxp3 + T regulatory cells in therapeutic dose aspirin-treated mice .
19153062	0	CD4	0,3	Foxp3	53,58	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD127|nsubj|CD25 CD127|dobj|cells cells|dep|express express|dobj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric_cancers progression .
19155519	0	CD4	38,41	Foxp3	49,54	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY analysis|nmod|CD25 analysis|dep|cells cells|amod|END_ENTITY	Phenotypic and functional analysis of CD4 + CD25 - Foxp3 + T cells in patients with systemic_lupus_erythematosus .
19214972	0	CD4	30,33	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Control of type_1_diabetes by CD4 + Foxp3 + regulatory T cells : lessons from mouse models and implications for human disease .
19221040	0	CD4	81,84	Foxp3	90,95	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4 + CD25 + Foxp3 + T regulatory cells that protects against graft-versus-host_disease .
19229109	0	CD4	27,30	Foxp3	36,41	CD4	Foxp3	920	50943	Gene	Gene	Tregs|nummod|START_ENTITY Tregs|compound|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
19234174	0	CD4	118,121	Foxp3	127,132	CD4	Foxp3	920	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human dendritic cells produce TGF-beta_1 under the influence of lung_carcinoma cells and prime the differentiation of CD4 + CD25 + Foxp3 + regulatory T cells .
19234199	0	CD4	59,62	Foxp3	52,57	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY priming|dep|cells priming|nmod|END_ENTITY	Selective priming and expansion of antigen-specific Foxp3 - CD4 + T cells during Listeria_monocytogenes infection .
19283777	0	CD4	125,128	Foxp3	76,81	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	anergy|compound|START_ENTITY cells|nmod|anergy tolerance|dep|cells tolerance|dep|loss loss|nmod|END_ENTITY	T-cell tolerance induced by repeated antigen stimulation : selective loss of Foxp3 - conventional CD4 T cells and induction of CD4 T-cell anergy .
19283777	0	CD4	96,99	Foxp3	76,81	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY tolerance|dep|cells tolerance|dep|loss loss|nmod|END_ENTITY	T-cell tolerance induced by repeated antigen stimulation : selective loss of Foxp3 - conventional CD4 T cells and induction of CD4 T-cell anergy .
19342638	0	CD4	54,57	Foxp3	77,82	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|nmod|+ +|compound|END_ENTITY	Activin a promotes the TGF-beta-induced conversion of CD4 + CD25 - T cells into Foxp3 + induced regulatory T cells .
19364517	0	CD4	10,13	Foxp3	19,24	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + T cells in peripheral blood of celiac_disease patients : correlation with dietary treatment .
19380824	0	CD4	57,60	Foxp3	27,32	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY regulation|nmod|cells regulation|nmod|END_ENTITY	Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1 .
19381159	0	CD4	52,55	Foxp3	45,50	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	SOCS1 negatively regulates the production of Foxp3 + CD4 + T cells in the thymus .
19448155	0	CD4	17,20	Foxp3	26,31	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
19452318	0	CD4	35,38	Foxp3	47,52	CD4	Foxp3	920	50943	Gene	Gene	formation|nmod|START_ENTITY +|nsubj|formation +|dobj|T-cells T-cells|compound|END_ENTITY	Enhanced formation and survival of CD4 + CD25hi Foxp3 + T-cells in chronic_lymphocytic_leukemia .
19494258	0	CD4	81,84	Foxp3	85,90	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	mechanism|compound|START_ENTITY mechanism|compound|END_ENTITY	Keratinocyte_growth_factor improves allogeneic bone marrow engraftment through a CD4 + Foxp3 + regulatory T cell-dependent mechanism .
19535644	0	CD4	117,120	Foxp3	127,132	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4 + CD25 + Foxp3 + T regulatory cells .
19609976	0	CD4	43,46	Foxp3	53,58	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY numbers|nmod|CD25 +|nsubj|numbers +|dobj|cells cells|amod|END_ENTITY	Increased numbers of thymic and peripheral CD4 + CD25 + Foxp3 + cells in the absence of CD5 signaling .
19616200	0	CD4	11,14	Foxp3	79,84	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19620303	0	CD4	45,48	Foxp3	20,25	CD4	Foxp3	920	50943	Gene	Gene	subset|compound|START_ENTITY thymocytes|nmod|subset thymocytes|nsubj|development development|nmod|+ +|amod|END_ENTITY	Rare development of Foxp3 + thymocytes in the CD4 + CD8 + subset .
19625166	0	CD4	189,192	Foxp3	198,203	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental_allergic_encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4 + CD25 + Foxp3 + regulatory T cells .
19665867	0	CD4	92,95	Foxp3	101,106	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4 + CD25 + Foxp3 + regulatory T cell population .
19706340	0	CD4	61,64	Foxp3	70,75	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naloxone can improve the anti-tumor immunity by reducing the CD4 + CD25 + Foxp3 + regulatory T cells in BALB/c mice .
19709757	0	CD4	23,26	Foxp3	32,37	CD4	Foxp3	920	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of inducible CD4 + CD25 + Foxp3 + regulatory T lymphocytes by porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- .
19740328	0	CD4	137,140	Foxp3	148,153	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4 + CD25 + Foxp3 + regulatory T cells .
19740339	0	CD4	66,69	Foxp3	71,76	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	IFN-gamma production in response to Tax 161-233 , and frequency of CD4 + Foxp3 + and Lin HLA-DRhigh CD123 + cells , discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population .
19770521	0	CD4	0,3	Foxp3	9,14	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Tregs resolve experimental lung_injury in mice and are present in humans with acute_lung_injury .
19841877	0	CD4	54,57	Foxp3	13,18	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY increases|dobj|cells increases|nsubj|Induction Induction|nmod|demethylation demethylation|amod|END_ENTITY	Induction of Foxp3 demethylation increases regulatory CD4 + CD25 + T cells and prevents the occurrence of diabetes in mice .
19845018	0	CD4	98,101	Foxp3	18,23	CD4	Foxp3	920	50943	Gene	Gene	Foxp3|compound|START_ENTITY identifying|dobj|Foxp3 importance|acl|identifying importance|nmod|antibody antibody|amod|END_ENTITY	The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4 + CD25 + Foxp3 + regulatory T cells .
19852824	0	CD4	88,91	Foxp3	43,48	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4 + Treg cells .
19915051	0	CD4	66,69	Foxp3	39,44	CD4	Foxp3	920	50943	Gene	Gene	START_ENTITY|nsubj|increase increase|nmod|ratio ratio|nmod|+ +|amod|END_ENTITY	Systemic increase in the ratio between Foxp3 + and IL-17-producing CD4 + T cells in healthy pregnancy but not in preeclampsia .
19949075	0	CD4	0,3	Foxp3	15,20	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T regulatory cells with limited TCR diversity in control of autoimmunity .
19953886	0	CD4	10,13	Foxp3	58,63	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Study|nmod|CD25 +|nsubj|Study +|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Study of CD4 + CD25 + regulatory T cells and expression of Foxp3 mRNA in bronchiolitis and glucocorticoid regulation -RSB- .
19961805	0	CD4	19,22	Foxp3	38,43	CD4	Foxp3	920	50943	Gene	Gene	comparison|nmod|START_ENTITY comparison|dep|END_ENTITY	-LSB- The comparison of CD4 -LRB- + -RRB- ; CD25 -LRB- high -RRB- ; Foxp3 -LRB- + -RRB- ; regulatory T cells between neonatal cord blood and adult peripheral blood . -RSB- .
19995950	0	CD4	55,58	Foxp3	48,53	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	c-Rel is required for the development of thymic Foxp3 + CD4 regulatory T cells .
20006940	0	CD4	27,30	Foxp3	40,45	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Effect|nmod|CD25 END_ENTITY|nsubj|Effect	Effect of in vitroexpanded CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cell therapy combined with lymphodepletion in murine skin allotransplantation .
20049877	0	CD4	58,61	Foxp3	38,43	CD4	Foxp3	920	50943	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	c-Rel is crucial for the induction of Foxp3 -LRB- + -RRB- regulatory CD4 -LRB- + -RRB- T cells but not T -LRB- H -RRB- 17 cells .
20059576	0	CD4	101,104	Foxp3	108,113	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|suppress suppress|nsubj|cells cells|amod|END_ENTITY	Prevention and treatment of experimental_autoimmune_encephalomyelitis with clonotypic CDR3 peptides : CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T-regulatory cells suppress interleukin-2-dependent expansion of myelin_basic_protein-specific T cells .
20080669	0	CD4	45,48	Foxp3	49,54	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Generation of regulatory dendritic cells and CD4 + Foxp3 + T cells by probiotics administration suppresses immune_disorders .
20081380	0	CD4	59,62	Foxp3	70,75	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20142839	0	CD4	56,59	Foxp3	0,5	CD4	Foxp3	12504(Tax:10090)	50943	Gene	Gene	stage|compound|START_ENTITY precedes|dobj|stage precedes|nsubj|induction induction|amod|END_ENTITY	Foxp3 induction in human and murine thymus precedes the CD4 + CD8 + stage but requires early T-cell receptor expression .
20357481	0	CD4	13,16	Foxp3	22,27	CD4	Foxp3	920	50943	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + IL-10 + T cells in HDM-allergic asthmatic children with or without SIT .
20378024	0	CD4	0,3	Foxp3	9,14	CD4	Foxp3	407098(Tax:9913)	506053(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T regulatory cells are not involved in oral desensitization .
20382706	0	CD4	46,49	Foxp3	23,28	CD4	Foxp3	920	50943	Gene	Gene	START_ENTITY|nsubj|IFN-gamma IFN-gamma|dep|END_ENTITY	Antigen-specific CD25 - Foxp3 - IFN-gamma -LRB- high -RRB- CD4 + T cells restrain the development of experimental_allergic_encephalomyelitis by suppressing Th17 .
20382886	0	CD4	54,57	Foxp3	65,70	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20394727	0	CD4	120,123	Foxp3	129,134	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4 + CD25 + Foxp3 + regulatory T cells and down-regulates cardiac allograft rejection .
20463648	0	CD4	101,104	Foxp3	105,110	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intravenous immunoglobulins promote skin allograft acceptance by triggering functional activation of CD4 + Foxp3 + T cells .
20477811	0	CD4	24,27	Foxp3	16,21	CD4	Foxp3	920	50943	Gene	Gene	cells|amod|START_ENTITY Distribution|appos|cells Distribution|nmod|END_ENTITY	Distribution of Foxp3 - , CD4 - and CD8-positive lymphocytic cells in benign and malignant prostate tissue .
20497692	0	CD4	69,72	Foxp3	4,9	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY converted|nmod|CD25 +|ccomp|converted +|nsubj|END_ENTITY	CD4 + Foxp3 + regulatory T cells converted by rapamycin from peripheral CD4 + CD25 -LRB- - -RRB- naive T cells display more potent regulatory ability in vitro .
20515837	0	CD4	0,3	Foxp3	15,20	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and hematologic_malignancies .
20522244	0	CD4	30,33	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	suppression|compound|START_ENTITY regulates|dobj|suppression regulates|nsubj|END_ENTITY	Foxp3 regulates human natural CD4 + CD25 + regulatory T-cell-mediated suppression of xenogeneic response .
20546740	0	CD4	26,29	Foxp3	30,35	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD39/ENTPD1 expression by CD4 + Foxp3 + regulatory T cells promotes hepatic metastatic_tumor growth in mice .
20591118	0	CD4	88,91	Foxp3	81,86	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Human visceral_leishmaniasis is not associated with expansion or accumulation of Foxp3 + CD4 cells in blood or spleen .
20639494	0	CD4	7,10	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Foxp3 + CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory_syncytial_virus_infection .
20688398	0	CD4	51,54	Foxp3	20,25	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY variants|nmod|+ variants|amod|END_ENTITY	Characterisation of Foxp3 splice variants in human CD4 + and CD8 + T cells -- identification of Foxp3 / \ 7 in human regulatory T cells .
20688398	0	CD4	51,54	Foxp3	92,97	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY variants|nmod|+ Characterisation|nmod|variants Characterisation|dep|identification identification|nmod|END_ENTITY	Characterisation of Foxp3 splice variants in human CD4 + and CD8 + T cells -- identification of Foxp3 / \ 7 in human regulatory T cells .
20713627	0	CD4	0,3	Foxp3	11,16	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells , dendritic cells , and circulating cytokines in uncomplicated malaria : do different parasite species elicit similar host responses ?
20729906	0	CD4	19,22	Foxp3	24,29	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + but not CD4 + Foxp3 + T cells as a regulatory subset in primary_biliary_cirrhosis .
20800824	0	CD4	43,46	Foxp3	49,54	CD4	Foxp3	920	50943	Gene	Gene	selection|nmod|START_ENTITY END_ENTITY|nsubj|selection	Thymic selection and lineage commitment of CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T lymphocytes .
20821727	0	CD4	75,78	Foxp3	96,101	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY inflammation|nmod|CD25 END_ENTITY|amod|inflammation	Control of Schistosoma_mansoni egg-induced inflammation by IL-4-responsive CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- CD103 -LRB- + -RRB- Foxp3 -LRB- - -RRB- cells is IL-10-dependent .
20832552	0	CD4	59,62	Foxp3	76,81	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY development|nmod|CD25 drugs|nmod|development Influence|nmod|drugs END_ENTITY|amod|Influence	Influence of immunosuppressive drugs on the development of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells in liver transplant recipients .
20848841	0	CD4	28,31	Foxp3	93,98	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY level|nmod|CD25 Studies|nmod|level +|nsubj|Studies +|nmod|expression expression|nmod|END_ENTITY	-LSB- Studies about the level of CD4 + CD25 + regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV_infection -RSB- .
20871628	0	CD4	96,99	Foxp3	107,112	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	2-Gy whole-body irradiation significantly alters the balance of CD4 + CD25 - T effector cells and CD4 + CD25 + Foxp3 + T regulatory cells in mice .
21057085	0	CD4	94,97	Foxp3	128,133	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY convert|dobj|CD25 agonists|dep|convert agonists|parataxis|+ +|nsubj|cells cells|nmod|END_ENTITY	Peroxisome proliferator-activated receptor a and y agonists together with TGF-b convert human CD4 + CD25 - T cells into functional Foxp3 + regulatory T cells .
21072213	0	CD4	0,3	Foxp3	9,14	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells depletion may attenuate the development of silica-induced lung_fibrosis in mice .
21124798	0	CD4	47,50	Foxp3	74,79	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|induction induction|amod|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
21255144	0	CD4	12,15	Foxp3	17,22	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Skin-homing CD4 + Foxp3 + T cells exert Th2-like function after staphylococcal superantigen stimulation in atopic_dermatitis patients .
21312192	0	CD4	79,82	Foxp3	5,10	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY share|nmod|cells share|nsubj|cells cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21312192	0	CD4	79,82	Foxp3	84,89	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21314851	0	CD4	16,19	Foxp3	31,36	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY circulating|dobj|CD25 T|dep|circulating T|nsubj|END_ENTITY	Low circulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- _ Foxp3 -LRB- + -RRB- T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure .
21376048	0	CD4	50,53	Foxp3	64,69	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human colonic myofibroblasts promote expansion of CD4 + CD25high Foxp3 + regulatory T cells .
21389253	0	CD4	50,53	Foxp3	54,59	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 contributes to maintaining a balance between CD4 + Foxp3 + regulatory T cells and effector CD4 + T cells required for immune control of blood-stage malaria_infection .
21395511	0	CD4	56,59	Foxp3	38,43	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY Role|dep|+ Role|nmod|activin_A activin_A|nmod|induction induction|nmod|+ +|amod|END_ENTITY	Role of activin_A in the induction of Foxp3 + and Foxp3 - CD4 + regulatory T cells .
21402894	0	CD4	64,67	Foxp3	46,51	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|induction induction|nmod|END_ENTITY	Cutting edge : De novo induction of functional Foxp3 + regulatory CD4 T cells in response to tissue-restricted self antigen .
21447271	0	CD4	1,4	Foxp3	10,15	CD4	Foxp3	920	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- CD4 + CD25 + Foxp3 + T lymphocytes : naturally occuring regulatory T cells -RSB- .
21469093	0	CD4	12,15	Foxp3	85,90	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY triggers|nsubj|activation triggers|nmod|cells cells|amod|END_ENTITY	Sub-optimal CD4 + T-cell activation triggers autonomous TGF-b-dependent conversion to Foxp3 + regulatory T cells .
21469094	0	CD4	111,114	Foxp3	122,127	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Steady state migratory RelB + langerin + dermal dendritic cells mediate peripheral induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells .
21472340	0	CD4	63,66	Foxp3	96,101	CD4	Foxp3	920	50943	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	CD4	87,90	Foxp3	67,72	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells END_ENTITY|dep|cells	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	CD4	87,90	Foxp3	96,101	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21511184	0	CD4	96,99	Foxp3	65,70	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Th17 cells express interleukin-10_receptor_and are controlled by Foxp3 and Foxp3 + regulatory CD4 + T cells in an interleukin-10-dependent manner .
21519344	0	CD4	13,16	Foxp3	26,31	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Induction|nmod|CD25 Induction|nmod|cells cells|amod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21519344	0	CD4	78,81	Foxp3	26,31	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY cells|dep|stimulation cells|amod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21528082	0	CD4	34,37	Foxp3	38,43	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Gastric_cancer cells induce human CD4 + Foxp3 + regulatory T cells through the production of TGF-b1 .
21558138	0	CD4	21,24	Foxp3	32,37	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
21600126	0	CD4	29,32	Foxp3	23,28	CD4	Foxp3	920	50943	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Study of fas-mediated Foxp3 + CD4 + CD25 + Treg cell apoptosis in patients with systemic_lupus_erythematosus -RSB- .
21604971	0	CD4	64,67	Foxp3	69,74	CD4	Foxp3	920	50943	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Transfer of cell membrane components via trogocytosis occurs in CD4 + Foxp3 + CD25 + regulatory T-cell contact-dependent suppression .
21604973	0	CD4	25,28	Foxp3	34,39	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Decreased frequencies of CD4 + CD25 + Foxp3 + cells and the potent CD103 + subset in peripheral lymph_nodes correlate with autoimmune_disease predisposition in some strains of mice .
21623989	0	CD4	49,52	Foxp3	42,47	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY conversion|dep|cells conversion|nmod|END_ENTITY	FTY720-induced conversion of conventional Foxp3 - CD4 + T cells to Foxp3 + regulatory T cells in NOD mice .
21623989	0	CD4	49,52	Foxp3	65,70	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	FTY720-induced conversion of conventional Foxp3 - CD4 + T cells to Foxp3 + regulatory T cells in NOD mice .
21640985	0	CD4	3,6	Foxp3	8,13	CD4	Foxp3	920	50943	Gene	Gene	correlate|compound|START_ENTITY correlate|compound|END_ENTITY	Do CD4 + Foxp3 + Treg cells correlate with transplant outcomes : a systematic review on recipients of solid organ transplantation .
21677778	0	CD4	26,29	Foxp3	123,128	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|differentiating differentiating|xcomp|helper helper|nmod|vivo vivo|nmod|expression expression|amod|END_ENTITY	Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression .
21708889	0	CD4	24,27	Foxp3	37,42	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Increase in circulating CD4 CD25 Foxp3 T cells in patients with Philadelphia-negative chronic_myeloproliferative_neoplasms during treatment with IFN-a .
21710488	0	CD4	71,74	Foxp3	41,46	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	The S. _ mansoni glycoprotein -1 induces Foxp3 expression in NOD mouse CD4 T cells .
21724410	0	CD4	71,74	Foxp3	65,70	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tissular T -LRB- regs -RRB- : a unique population of adipose-tissue-resident Foxp3 + CD4 + T cells that impacts organismal metabolism .
21726337	0	CD4	26,29	Foxp3	9,14	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY expressing|dobj|+ END_ENTITY|acl|expressing	Maternal Foxp3 expressing CD4 + CD25 + and CD4 + CD25 - regulatory T-cell populations are enriched in human early normal pregnancy decidua : a phenotypic study of paired decidual and peripheral blood samples .
21734238	0	CD4	115,118	Foxp3	124,129	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin and IL-2 reduce lethal acute_graft-versus-host_disease associated with increased expansion of donor type CD4 + CD25 + Foxp3 + regulatory T cells .
21785365	0	CD4	0,3	Foxp3	13,18	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 CD25 Foxp3 regulatory T cells suppress cardiac_fibrosis in the hypertensive heart .
21792941	0	CD4	71,74	Foxp3	47,52	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY cells|appos|+ factor|nsubj|cells ratio|parataxis|factor ratio|nmod|cells cells|appos|+ +|compound|END_ENTITY	The ratio of intra-tumoral regulatory T cells -LRB- Foxp3 + -RRB- / helper T cells -LRB- CD4 + -RRB- is a prognostic factor and associated with recurrence pattern in gastric_cardia_cancer .
21843083	0	CD4	32,35	Foxp3	41,46	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Neem leaf glycoprotein inhibits CD4 + CD25 + Foxp3 + Tregs to restrict murine tumor growth .
21873213	0	CD4	107,110	Foxp3	43,48	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY subsets|nmod|T impact|dep|subsets impact|nmod|selection selection|nmod|+ +|amod|END_ENTITY	Quantitative impact of thymic selection on Foxp3 + and Foxp3 - subsets of self-peptide/MHC class II-specific CD4 + T cells .
21873239	0	CD4	0,3	Foxp3	13,18	CD4	Foxp3	920	50943	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	CD4 CD25 Foxp3 regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion .
21875661	0	CD4	76,79	Foxp3	89,94	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY enhancement|nmod|CD25 enhancement|dep|END_ENTITY	Cortex Mori Radicis extract exerts antiasthmatic effects via enhancement of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and inhibition of Th2 cytokines in a mouse asthma model .
21916916	0	CD4	41,44	Foxp3	21,26	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Transient attenuated Foxp3 expression on CD4 T cells treated with 7D4 mAb contributes to the control of parasite burden in DBA/2 mice infected with lethal Plasmodium_chabaudi_chabaudi AS .
21983870	0	CD4	26,29	Foxp3	35,40	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations of peripheral CD4 + CD25 + Foxp3 + T regulatory cells in mice with STZ-induced diabetes .
22005288	0	CD4	13,16	Foxp3	24,29	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
22034573	0	CD4	21,24	Foxp3	30,35	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	Thioperamide induces CD4 CD25 Foxp3 regulatory T lymphocytes in the lung mucosa of allergic mice through its action on dendritic cells .
22066012	0	CD4	75,78	Foxp3	68,73	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	c-Rel controls multiple discrete steps in the thymic development of Foxp3 + CD4 regulatory T cells .
22079196	0	CD4	36,39	Foxp3	0,5	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY critical|nmod|cells critical|nsubj|END_ENTITY	Foxp3 is critical for human natural CD4 + CD25 + regulatory T cells to suppress alloimmune response .
22110383	0	CD4	92,95	Foxp3	98,103	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Regulating the adaptive immune response to blood-stage_malaria : role of dendritic cells and CD4 Foxp3 regulatory T cells .
22164498	0	CD4	63,66	Foxp3	74,79	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of excreted/secreted antigens of Toxoplasma_gondii on CD4 + CD25 + Foxp3 + T cells and NK cells of melanoma-bearing mice -RSB- .
22192331	0	CD4	13,16	Foxp3	28,33	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	Responses of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- and IL-10-secreting type I T regulatory cells to cluster-specific_immunotherapy for allergic_rhinitis in children .
22215739	0	CD4	77,80	Foxp3	82,87	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Failure to recruit anti-inflammatory CD103 + dendritic cells and a diminished CD4 + Foxp3 + regulatory T cell pool in mice that display excessive_lung_inflammation and increased susceptibility to Mycobacterium_tuberculosis .
22220406	0	CD4	36,39	Foxp3	45,50	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Augmentation of regulatory T cells -LRB- CD4 + CD25 + Foxp3 + -RRB- correlates with tumor stage in patients with colorectal_cancer .
22222264	0	CD4	39,42	Foxp3	57,62	CD4	Foxp3	920	50943	Gene	Gene	Adalimumab|dobj|START_ENTITY Adalimumab|dep|END_ENTITY	Adalimumab specifically induces CD3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- CD127 -LRB- - -RRB- T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis : a non-randomized pilot intervention study .
22270834	0	CD4	57,60	Foxp3	121,126	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	naive|dep|START_ENTITY cells|amod|naive cells|nmod|END_ENTITY	Dendritic cells with TGF-b1 and IL-2 differentiate naive CD4 + T cells into alloantigen-specific and allograft protective Foxp3 + regulatory T cells .
22322668	0	CD4	79,82	Foxp3	83,88	CD4	Foxp3	920	50943	Gene	Gene	functional|dep|START_ENTITY END_ENTITY|amod|functional	Immune suppression in premalignant respiratory_papillomas : enriched functional CD4 + Foxp3 + regulatory T cells and PD-1 / PD-L1 / L2 expression .
22406048	0	CD4	111,114	Foxp3	82,87	CD4	Foxp3	920	50943	Gene	Gene	T|compound|START_ENTITY demethylation|nmod|T cells|amod|demethylation increasing|dobj|cells increasing|iobj|END_ENTITY	Total_glucosides_of_paeony induces regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells by increasing Foxp3 demethylation in lupus CD4 -LRB- + -RRB- T cells .
22406048	0	CD4	46,49	Foxp3	82,87	CD4	Foxp3	920	50943	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|CD25 CD25|dep|cells cells|acl|increasing increasing|iobj|END_ENTITY	Total_glucosides_of_paeony induces regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells by increasing Foxp3 demethylation in lupus CD4 -LRB- + -RRB- T cells .
22426168	0	CD4	0,3	Foxp3	6,11	CD4	Foxp3	920	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 Foxp3 Treg and its ICOS subsets in patients with myocardial_infarction .
22466569	0	CD4	46,49	Foxp3	59,64	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	Lactobacillus_acidophilus_strain L-92 induces CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and suppresses allergic contact_dermatitis .
22539290	0	CD4	14,17	Foxp3	21,26	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Activation of CD4 Foxp3 regulatory T cells proceeds normally in the absence of B cells during EAE .
22564624	0	CD4	73,76	Foxp3	88,93	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY cell|nmod|CD25 cytotoxicity|nmod|cell Inhibition|nmod|cytotoxicity END_ENTITY|nsubj|Inhibition	Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4 CD25 Foxp3 regulatory T cells in vitro .
22587982	0	CD4	73,76	Foxp3	141,146	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY ratio|nmod|CD25 Decoction|nmod|ratio Effects|nmod|Decoction +|nsubj|Effects +|nmod|END_ENTITY	-LSB- Effects of Chinese herbal medicine Feiyanning Decoction on the ratio of CD4 + CD25 + regulatory T cells and expression of transcription factor Foxp3 in mice bearing Lewis_lung_carcinoma -RSB- .
22609353	0	CD4	60,63	Foxp3	73,78	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22681667	0	CD4	100,103	Foxp3	105,110	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Donor-specific CD8 + Foxp3 + T cells protect skin allografts and facilitate induction of conventional CD4 + Foxp3 + regulatory T cells .
22718263	0	CD4	150,153	Foxp3	154,159	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic_airway_disease are CD5 + , express TGF-b , and co-localize with CD4 + Foxp3 + T cells .
22749982	0	CD4	61,64	Foxp3	54,59	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Induction|dep|CD25 Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22769982	0	CD4	105,108	Foxp3	118,123	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY increasing|iobj|CD25 increasing|iobj|+ +|compound|END_ENTITY	Pretreatment of rapamycin before allogenic corneal transplant promotes graft survival through increasing CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
22773728	0	CD4	11,14	Foxp3	15,20	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|induce induce|nsubj|cells cells|amod|END_ENTITY	Polyclonal CD4 + Foxp3 + Treg cells induce TGFb-dependent tolerogenic dendritic cells that suppress the murine lupus-like_syndrome .
22776176	0	CD4	93,96	Foxp3	132,137	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4 + effector T cells and induction of Foxp3 + regulatory T cells .
22817851	0	CD4	0,3	Foxp3	18,23	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- cells increased in the peritoneal fluid of patients with endometriosis .
22873180	0	CD4	113,116	Foxp3	122,127	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic_dermatitis via generation of CD4 + CD25 + Foxp3 + T cells .
22884147	0	CD4	17,20	Foxp3	30,35	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY changes|nmod|CD25 END_ENTITY|nsubj|changes	Early changes of CD4 CD25 Foxp3 regulatory T cells and Th1/Th2 , Tc1/Tc2 profiles in the peripheral blood of rats with controlled hemorrhagic_shock and no fluid resuscitation .
22891805	0	CD4	107,110	Foxp3	116,121	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4 -LRB- + -RRB- / CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- cells .
22891805	0	CD4	99,102	Foxp3	116,121	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4 -LRB- + -RRB- / CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- cells .
22921804	0	CD4	24,27	Foxp3	37,42	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|nmod|cells cells|amod|END_ENTITY	Increased proportion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells during early-stage sepsis in ICU patients .
22928057	0	CD4	15,18	Foxp3	22,27	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY END_ENTITY|nsubj|Involvement	Involvement of CD4 Foxp3 regulatory T cells in persistence of Leishmania_donovani in the liver of alymphoplastic aly/aly mice .
23017670	0	CD4	0,3	Foxp3	11,16	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|acl:relcl|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
23041608	0	CD4	119,122	Foxp3	128,133	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activation of the aryl_hydrocarbon_receptor reduces the number of precursor and effector T cells , but preserves thymic CD4 + CD25 + Foxp3 + regulatory T cells .
23045606	0	CD4	27,30	Foxp3	31,36	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neuropilin_1 deficiency on CD4 + Foxp3 + regulatory T cells impairs mouse melanoma growth .
23046932	0	CD4	61,64	Foxp3	76,81	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|dep|CD25 CD25|dep|END_ENTITY	-LSB- Influence of anti-ICOS antibody on quantity and function of CD4 -LRB- + -RRB- ; CD25 -LRB- + -RRB- ; Foxp3 -LRB- + -RRB- ; Treg from lymph and blood of rats with bronchial_asthma -RSB- .
23127412	0	CD4	19,22	Foxp3	36,41	CD4	Foxp3	920	50943	Gene	Gene	START_ENTITY|dep|CD25 CD25|dep|END_ENTITY	-LSB- The subpopulation CD4 -LRB- + -RRB- ; CD25 -LRB- + -RRB- ; Foxp3 -LRB- + -RRB- ; / CD127 -LRB- low / - -RRB- ; regulatory T cells in peripheral blood of HIV-infected patients correlated with disease progression -RSB- .
23128958	0	CD4	39,42	Foxp3	43,48	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Macrophages overexpressing Aire induce CD4 + Foxp3 + T cells .
23185797	0	CD4	0,3	Foxp3	9,14	CD4	Foxp3	920	50943	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Treg and TGF-beta play important roles in pathogenesis of Uygur cervical_carcinoma .
23186751	0	CD4	0,3	Foxp3	9,14	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	CD4 + CD25 + Foxp3 + T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma .
23277487	0	CD4	47,50	Foxp3	51,56	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	TNFR2 is critical for the stabilization of the CD4 + Foxp3 + regulatory T. cell phenotype in the inflammatory environment .
23284056	0	CD4	26,29	Foxp3	30,35	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Varicella zoster-specific CD4 + Foxp3 + T cells accumulate after cutaneous antigen challenge in humans .
23436577	0	CD4	39,42	Foxp3	44,49	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Beta2-adrenergic_receptor signaling in CD4 + Foxp3 + regulatory T cells enhances their suppressive function in a PKA-dependent manner .
23467933	0	CD4	35,38	Foxp3	39,44	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antigen-specific memory regulatory CD4 + Foxp3 + T cells control memory responses to influenza_virus_infection .
23530124	0	CD4	74,77	Foxp3	35,40	CD4	Foxp3	920	50943	Gene	Gene	development|amod|START_ENTITY development|compound|END_ENTITY	The thymic medulla is required for Foxp3 + regulatory but not conventional CD4 + thymocyte development .
23537702	0	CD4	59,62	Foxp3	65,70	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Systematic evaluation of 640 FDA drugs for their effect on CD4 Foxp3 regulatory T cells using a novel cell-based high throughput screening assay .
23547099	0	CD4	61,64	Foxp3	65,70	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	development|compound|START_ENTITY development|compound|END_ENTITY	Epithelial and dendritic cells in the thymic medulla promote CD4 + Foxp3 + regulatory T cell development via the CD27-CD70 pathway .
23595594	0	CD4	68,71	Foxp3	83,88	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY increase|nmod|CD25 induce|dobj|increase induce|nsubj|END_ENTITY	Radiofrequency ablation does not induce the significant increase of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells compared with surgical resection in Hepal-6 tumor model .
23632310	0	CD4	131,134	Foxp3	144,149	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY effects|nmod|CD25 effects|acl|END_ENTITY	Immunoregulatory effects of glycyrrhizic_acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 + regulatory T cells in ovalbumin-sensitized mice .
23725550	0	CD4	79,82	Foxp3	89,94	CD4	Foxp3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Low-dose temozolomide before dendritic-cell vaccination reduces -LRB- specifically -RRB- CD4 + CD25 + + Foxp3 + regulatory T-cells in advanced melanoma patients .
23733880	0	CD4	149,152	Foxp3	132,137	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY novo|nmod|cells novo|compound|END_ENTITY	Cutting edge : inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103 + but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4 + T cells and promote airway tolerance .
23734780	0	CD4	34,37	Foxp3	43,48	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
23749427	0	CD4	55,58	Foxp3	66,71	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
23750800	0	CD4	98,101	Foxp3	91,96	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3 + CD4 + graft infiltrating cells .
23773923	0	CD4	35,38	Foxp3	28,33	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|role role|nmod|END_ENTITY	The role of IL-17-producing Foxp3 + CD4 + T cells in inflammatory_bowel_disease and colon_cancer .
23859136	0	CD4	105,108	Foxp3	98,103	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Loss of b-arrestin 2 exacerbates experimental_autoimmune_encephalomyelitis with reduced number of Foxp3 + CD4 + regulatory T cells .
23881298	0	CD4	0,3	Foxp3	9,14	CD4	Foxp3	920	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	CD4 + CD25 + Foxp3 regulatory T cells and vascular_dysfunction in hypertension .
23922690	0	CD4	11,14	Foxp3	15,20	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Regulatory CD4 + Foxp3 + T cells control the severity of anaphylaxis .
23949701	0	CD4	22,25	Foxp3	35,40	CD4	Foxp3	920	50943	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute_respiratory_distress_syndrome is associated with increased 30-day mortality .
23956419	0	CD4	0,3	Foxp3	13,18	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 CD25 Foxp3 regulatory T cells promote Th17 responses and genital tract inflammation upon intracellular Chlamydia muridarum infection .
24055067	0	CD4	0,3	Foxp3	86,91	CD4	Foxp3	12504(Tax:10090)	50943	Gene	Gene	blockade|compound|START_ENTITY inhibits|nsubj|blockade inhibits|ccomp|T T|xcomp|independent independent|nmod|Tregs Tregs|compound|END_ENTITY	CD4 blockade directly inhibits mouse and human CD4 -LRB- + -RRB- T cell functions independent of Foxp3 -LRB- + -RRB- Tregs .
24055067	0	CD4	47,50	Foxp3	86,91	CD4	Foxp3	920	50943	Gene	Gene	T|nsubj|START_ENTITY T|xcomp|independent independent|nmod|Tregs Tregs|compound|END_ENTITY	CD4 blockade directly inhibits mouse and human CD4 -LRB- + -RRB- T cell functions independent of Foxp3 -LRB- + -RRB- Tregs .
24076465	0	CD4	77,80	Foxp3	45,50	CD4	Foxp3	920	50943	Gene	Gene	co-cultured|dep|START_ENTITY lymphocytes|amod|co-cultured cells|nmod|lymphocytes T|dobj|cells T|nsubj|END_ENTITY	Human lung fibroblasts increase CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells in co-cultured CD4 -LRB- + -RRB- lymphocytes .
24097227	0	CD4	75,78	Foxp3	58,63	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY expressing|dobj|cells END_ENTITY|acl|expressing	Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4 + T cells and defective suppressive function of circulating Foxp3 + regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory_bowel_disease patients .
24098053	0	CD4	25,28	Foxp3	29,34	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Reduced effectiveness of CD4 + Foxp3 + regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune_thyroiditis .
24151582	0	CD4	85,88	Foxp3	100,105	CD4	Foxp3	920	50943	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Chronic_heat_stress inhibits immune responses to H5N1 vaccination through regulating CD4 CD25 Foxp3 Tregs .
24155942	0	CD4	0,3	Foxp3	58,63	CD4	Foxp3	920	50943	Gene	Gene	CD62L|compound|START_ENTITY CD62L|acl:relcl|converted converted|nmod|END_ENTITY	CD4 -LRB- + -RRB- CD62L -LRB- + -RRB- central memory_T cells can be converted to Foxp3 -LRB- + -RRB- T cells .
24339053	0	CD4	140,143	Foxp3	151,156	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
24366217	0	CD4	156,159	Foxp3	169,174	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin _ D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4 CD25 Foxp3 regulatory T cells .
24369813	0	CD4	0,3	Foxp3	31,36	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|dep|gene gene|dep|END_ENTITY	CD4 CD25 FOXP3 T cells , Foxp3 gene and protein expression contribute to antiasthmatic effects of San ` ao_decoction in mice model of asthma .
24391000	0	CD4	105,108	Foxp3	33,38	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY detection|nmod|cells END_ENTITY|nmod|detection	Application and effects of mouse Foxp3 antibody and fixation/permeabilization buffer on the detection of CD4 + regulatory T cells in various mammal species .
24452947	0	CD4	33,36	Foxp3	44,49	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24465502	0	CD4	0,3	Foxp3	60,65	CD4	Foxp3	920	50943	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|acl|expressing expressing|dobj|END_ENTITY	CD4 + primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10 , suppressing CD4 and CD8 T cells .
24465502	0	CD4	89,92	Foxp3	60,65	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY suppressing|dobj|cells +|advcl|suppressing +|dobj|cells cells|acl|expressing expressing|dobj|END_ENTITY	CD4 + primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10 , suppressing CD4 and CD8 T cells .
24557710	0	CD4	128,131	Foxp3	137,142	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Narrowband ultraviolet B phototherapy ameliorates acute_graft-versus-host_disease by a mechanism involving in vivo expansion of CD4 + CD25 + Foxp3 + regulatory T cells .
24617045	0	CD4	19,22	Foxp3	29,34	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Role|nmod|CD25 +|nsubj|Role +|dobj|cells cells|amod|END_ENTITY	Role of regulatory CD4 + CD25 + Foxp3 T cells in bronchial asthma in Egyptian children .
24668348	0	CD4	44,47	Foxp3	57,62	CD4	Foxp3	920	50943	Gene	Gene	CD69|compound|START_ENTITY suppresses|nummod|CD69 suppresses|amod|END_ENTITY	Human hepatocellular_carcinoma-infiltrating CD4 CD69 Foxp3 regulatory T cell suppresses T cell response via membrane-bound TGF-b1 .
24690994	0	CD4	69,72	Foxp3	130,135	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+25|compound|START_ENTITY Foxp3|nummod|+25 Foxp3|acl|+ +|dobj|suppression suppression|nmod|downregulation downregulation|amod|END_ENTITY	Transgene IL-6 enhances DC-stimulated CTL responses by counteracting CD4 +25 + Foxp3 + regulatory T cell suppression via IL-6-induced Foxp3 downregulation .
24690994	0	CD4	69,72	Foxp3	76,81	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+25|compound|START_ENTITY END_ENTITY|nummod|+25	Transgene IL-6 enhances DC-stimulated CTL responses by counteracting CD4 +25 + Foxp3 + regulatory T cell suppression via IL-6-induced Foxp3 downregulation .
24774748	0	CD4	0,3	Foxp3	13,18	CD4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 CD25 Foxp3 T cells : a marker for lupus_nephritis ?
24786398	0	CD4	7,10	Foxp3	0,5	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Foxp3 + CD4 + T cells improve healing after myocardial_infarction by modulating monocyte/macrophage differentiation .
24798620	0	CD4	29,32	Foxp3	42,47	CD4	Foxp3	920	50943	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	TGF-b-dependent induction of CD4 CD25 Foxp3 Tregs by liver sinusoidal endothelial cells .
24813240	0	CD4	87,90	Foxp3	104,109	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY capacity|nmod|CD25 facilitates|dobj|capacity Interleukin-17|dep|facilitates Interleukin-17|dep|END_ENTITY	Interleukin-17 facilitates the immune suppressor capacity of high-grade glioma-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells via releasing transforming_growth_factor_beta .
24832045	0	CD4	68,71	Foxp3	72,77	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	T-Cells|compound|START_ENTITY T-Cells|compound|END_ENTITY	The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4 + Foxp3 + Regulatory T-Cells .
24931519	0	CD4	39,42	Foxp3	19,24	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 expression|amod|END_ENTITY	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
25030097	0	CD4	49,52	Foxp3	62,67	CD4	Foxp3	920	50943	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Comment on Adamzik et al. : An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory_distress_syndrome is associated with increased 30-day mortality .
25054604	0	CD4	121,124	Foxp3	134,139	CD4	Foxp3	920	50943	Gene	Gene	Treg|nummod|START_ENTITY Treg|compound|END_ENTITY	Patients with systemic_lupus_erythematosus and secondary_antiphospholipid_syndrome have decreased numbers of circulating CD4 CD25 Foxp3 Treg and CD3 CD19 B cells .
25139358	0	CD4	6,9	Foxp3	11,16	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Donor CD4 + Foxp3 + regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice .
25193380	0	CD4	51,54	Foxp3	69,74	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY targets|nmod|CD25 targets|dep|END_ENTITY	Epigenetic enzymes are the therapeutic targets for CD4 -LRB- + -RRB- CD25 -LRB- + / high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
25199644	0	CD4	52,55	Foxp3	56,61	CD4	Foxp3	920	50943	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	CD4	52,55	Foxp3	80,85	CD4	Foxp3	920	50943	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs CXCR5|dep|Bregs numbers|nmod|CXCR5 +|nsubj|numbers +|dobj|cells cells|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	CD4	70,73	Foxp3	56,61	CD4	Foxp3	920	50943	Gene	Gene	CXCR5|compound|START_ENTITY CXCR5|dep|Bregs Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	CD4	70,73	Foxp3	80,85	CD4	Foxp3	920	50943	Gene	Gene	CXCR5|compound|START_ENTITY numbers|nmod|CXCR5 +|nsubj|numbers +|dobj|cells cells|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25271532	0	CD4	91,94	Foxp3	85,90	CD4	Foxp3	920	50943	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Mono-allergic and poly-allergic_rhinitis patients have comparable numbers of mucosal Foxp3 + CD4 + T lymphocytes .
25275597	0	CD4	0,3	Foxp3	4,9	CD4	Foxp3	920	50943	Gene	Gene	differentiation|compound|START_ENTITY differentiation|compound|END_ENTITY	CD4 + Foxp3 + regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic_lesions .
25393309	0	CD4	54,57	Foxp3	124,129	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY resistant|nsubj|cells resistant|nmod|cells cells|compound|END_ENTITY	BDC12-4 .1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3 + T regulatory cells .
25522145	0	CD4	27,30	Foxp3	31,36	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Ameliorate|compound|START_ENTITY Ameliorate|compound|END_ENTITY	Parasitic Nematode-Induced CD4 + Foxp3 + T Cells Can Ameliorate Allergic Airway Inflammation .
25523567	0	CD4	10,13	Foxp3	23,28	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Roles|nmod|CD25 END_ENTITY|nsubj|Roles	-LSB- Roles of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and IL-33 in the pathogenesis of asthma in children -RSB- .
25548231	0	CD4	76,79	Foxp3	39,44	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY population|nmod|cells defines|dobj|population defines|nsubj|regulation regulation|nmod|END_ENTITY	Cutting edge : epigenetic regulation of Foxp3 defines a stable population of CD4 + regulatory T cells in tumors from mice and humans .
25560411	0	CD4	51,54	Foxp3	104,109	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|nmod|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
25581421	0	CD4	60,63	Foxp3	43,48	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Studies Studies|nmod|LAG3 LAG3|compound|END_ENTITY	Characterization and Functional Studies of Foxp3 -LRB- - -RRB- LAG3 -LRB- + -RRB- CD4 -LRB- + -RRB- Regulatory T Cells Induced by Mucosal B Cells .
25595257	0	CD4	91,94	Foxp3	100,105	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4 + CD25 + Foxp3 + T cells -LRB- Tregs -RRB- in a mouse study for active DNA Ab42 immunotherapy .
25701137	0	CD4	70,73	Foxp3	74,79	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Methionine_enkephalin -LRB- MENK -RRB- inhibits tumor growth through regulating CD4 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- in mice .
25712878	0	CD4	53,56	Foxp3	44,49	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Deficiency of decorin induces expression of Foxp3 in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells in a murine model of allergic_asthma .
25771887	0	CD4	48,51	Foxp3	38,43	CD4	Foxp3	920	50943	Gene	Gene	IL-17A|compound|START_ENTITY /|iobj|IL-17A /|nsubj|role role|nmod|END_ENTITY	The possible role of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- / CD4 -LRB- + -RRB- IL-17A -LRB- + -RRB- cell imbalance in the autoimmunity of patients with Hashimoto_thyroiditis .
25772268	0	CD4	90,93	Foxp3	97,102	CD4	Foxp3	920	50943	Gene	Gene	CD25|nummod|START_ENTITY CD25|compound|END_ENTITY	The effect of extracorporeal photopheresis alone or in combination therapy on circulating CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells in patients with leukemic cutaneous_T-cell_lymphoma .
25848068	0	CD4	88,91	Foxp3	51,56	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Population|nmod|Cells Defines|dobj|Population Defines|nsubj|Comment Comment|nmod|Edge Edge|dep|Regulation Regulation|nmod|END_ENTITY	Comment on `` Cutting Edge : Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4 + Regulatory T Cells in Tumors from Mice and Humans '' .
25848069	0	CD4	100,103	Foxp3	63,68	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Population|nmod|cells Defines|dobj|Population Defines|nsubj|Response Response|nmod|Comment Comment|nmod|Edge Edge|dep|Regulation Regulation|nmod|END_ENTITY	Response to Comment on `` Cutting Edge : Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4 + Regulatory T cells in Tumors from Mice and Humans '' .
25915882	0	CD4	30,33	Foxp3	24,29	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Decreased proportion of Foxp3 + CD4 + regulatory T cells contributes to the development of hypertension in genetically hypertensive rats .
25915882	0	CD4	30,33	Foxp3	24,29	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Decreased proportion of Foxp3 + CD4 + regulatory T cells contributes to the development of hypertension in genetically hypertensive rats .
25973010	0	CD4	51,54	Foxp3	31,36	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	BTLA associates with increased Foxp3 expression in CD4 -LRB- + -RRB- T cells in dextran sulfate sodium-induced colitis .
26004193	0	CD4	59,62	Foxp3	63,68	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vitamin_A supplementation leads to increases in regulatory CD4 + Foxp3 + LAP + T cells in mice .
26063731	0	CD4	48,51	Foxp3	28,33	CD4	Foxp3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells expression|amod|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	CD4	48,51	Foxp3	57,62	CD4	Foxp3	920	50943	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26214407	0	CD4	15,18	Foxp3	26,31	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY Correlation|nmod|CD25 +|nsubj|Correlation +|dobj|Treg Treg|compound|END_ENTITY	Correlation of CD4 + CD25 + Foxp3 + Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis .
26251265	0	CD4	125,128	Foxp3	132,137	CD4	Foxp3	920	50943	Gene	Gene	CD73|nmod|START_ENTITY expression|nmod|CD73 transforming_growth_factor-b|nmod|expression END_ENTITY|amod|transforming_growth_factor-b	1a,25-dihydroxyvitamin _ D3 acts via transforming_growth_factor-b to up-regulate expression of immunosuppressive CD73 on human CD4 -LRB- + -RRB- Foxp3 -LRB- - -RRB- T cells .
26273136	0	CD4	29,32	Foxp3	42,47	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY CD25|nsubj|Effect CD25|xcomp|Cells Cells|nsubj|END_ENTITY	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
26283421	0	CD4	0,3	Foxp3	13,18	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- T cells play a role in tuberculous_hydrothorax rather than malignant hydrothorax .
26283421	0	CD4	0,3	Foxp3	13,18	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- T cells play a role in tuberculous_hydrothorax rather than malignant hydrothorax .
26309858	0	CD4	110,113	Foxp3	120,125	CD4	Foxp3	24932(Tax:10116)	317382(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY CD25|acl|+ +|dobj|cells cells|amod|END_ENTITY	Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4 + CD25 + Foxp3 regulatory T cells .
26438270	0	CD4	93,96	Foxp3	106,111	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY correlates|nmod|CD25 correlates|dobj|generation generation|amod|END_ENTITY	Up-regulated S100_calcium_binding_protein_A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
26453746	0	CD4	27,30	Foxp3	61,66	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY +|nsubj|Expression +|dobj|Induction Induction|compound|END_ENTITY	Eomesodermin Expression in CD4 + T Cells Restricts Peripheral Foxp3 Induction .
26495986	0	CD4	122,125	Foxp3	126,131	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4 + Foxp3 + Regulatory T Cells .
26553468	0	CD4	15,18	Foxp3	71,76	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	responses|nummod|START_ENTITY responses|nmod|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26590147	0	CD4	51,54	Foxp3	55,60	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effect of bacillus Calmette-Gu rin vaccination on CD4 + Foxp3 + T cells during acquired immune response to Mycobacterium_tuberculosis infection .
26604855	0	CD4	63,66	Foxp3	47,52	CD4	Foxp3	920	50943	Gene	Gene	T|nsubj|START_ENTITY T|advcl|infiltrating infiltrating|dobj|CD4 CD4|compound|END_ENTITY	The prognostic influence of tumor infiltrating Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- , CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells in resected non-small_cell_lung_cancer .
26615520	0	CD4	76,79	Foxp3	89,94	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY activation|nmod|CD25 activation|nmod|cells cells|amod|END_ENTITY	Human umbilical vein endothelial cells promote the inhibitory activation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via PD-L1 .
26631955	0	CD4	113,116	Foxp3	137,142	CD4	Foxp3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	CD19 -LRB- + -RRB- IL-10 -LRB- + -RRB- regulatory B cells affect survival of tongue_squamous_cell_carcinoma patients and induce resting CD4 -LRB- + -RRB- T cells to CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
26673565	0	CD4	0,3	Foxp3	16,21	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- Treg_deficiency in a Brazilian patient with Gaucher_disease and lupus_nephritis .
26678292	0	CD4	105,108	Foxp3	118,123	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY correlates|nmod|CD25 correlates|nsubj|generation generation|nummod|END_ENTITY	Erratum to : Up-regulated S100 calcium binding protein A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
26752376	0	CD4	22,25	Foxp3	61,66	CD4	Foxp3	920	50943	Gene	Gene	T|compound|START_ENTITY Conditioning|nmod|T Conditioning|dobj|cells cells|nmod|END_ENTITY	Conditioning of naive CD4 -LRB- + -RRB- T cells for enhanced peripheral Foxp3 induction by nonspecific bystander_inflammation .
26862849	0	CD4	13,16	Foxp3	22,27	CD4	Foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY Frequency|nmod|CD25 +|nsubj|Frequency +|dobj|cells cells|amod|END_ENTITY	Frequency of CD4 + CD25 + Foxp3 + cells in peripheral blood in relation to urinary bladder_cancer malignancy indicators before and after surgical removal .
26886923	0	CD4	50,53	Foxp3	54,59	CD4	Foxp3	920	50943	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Comparative Analysis of Protocols to Induce Human CD4 + Foxp3 + Regulatory T Cells by Combinations of IL-2 , TGF-beta , Retinoic_Acid , Rapamycin and Butyrate .
26927553	0	CD4	69,72	Foxp3	18,23	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Tubacin promotes Foxp3 expression and suppressive function of mouse CD4 -LRB- + -RRB- ; CD25 -LRB- + -RRB- ; regulatory T cells -RSB- .
27016139	0	CD4	111,114	Foxp3	91,96	CD4	Foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY inducing|nmod|cells inducing|dobj|expression expression|amod|END_ENTITY	Granulocytic myeloid-derived suppressor cells maintain feto-maternal tolerance by inducing Foxp3 expression in CD4 + CD25-T cells by activation of the TGF-b/b-catenin pathway .
19955046	0	CD4	27,30	Fyn	0,3	CD4	Fyn	920	2534	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nsubj|END_ENTITY	Fyn and CD70 expression in CD4 + T cells from patients with systemic_lupus_erythematosus .
10078545	0	CD4	72,75	GAD65	47,52	CD4	GAD65	920	2572	Gene	Gene	mice|compound|START_ENTITY using|dobj|mice mapped|xcomp|using END_ENTITY|acl|mapped	Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4 , DQA1 * 0301 , DQB1 * 0302 transgenic IA -LRB- null -RRB- NOD mice .
10439311	0	CD4	0,3	GAD65	102,107	CD4	GAD65	920	2572	Gene	Gene	+|compound|START_ENTITY recognize|nsubj|+ recognize|dobj|epitopes epitopes|compound|END_ENTITY	CD4 + and CD8 + T-cell clones from congenital_rubella_syndrome patients with IDDM recognize overlapping GAD65 protein epitopes .
11905849	0	CD4	49,52	GAD65	100,105	CD4	GAD65	920	2572	Gene	Gene	cell|compound|START_ENTITY profiles|nmod|cell Complexity|nmod|profiles epitopes|nsubj|Complexity epitopes|nmod|END_ENTITY	Complexity of human immune response profiles for CD4 + T cell epitopes from the diabetes autoantigen GAD65 .
20370569	0	CD4	159,162	GAD65	184,189	CD4	GAD65	920	2572	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	A low antigen dose selectively promotes expansion of high-avidity autoreactive T cells with distinct phenotypic characteristics : a study of human autoreactive CD4 + T cells specific for GAD65 .
20503259	0	CD4	20,23	GAD65	75,80	CD4	GAD65	920	2572	Gene	Gene	cells|compound|START_ENTITY cells|nmod|decarboxylase decarboxylase|appos|END_ENTITY	Characterization of CD4 + T cells specific for glutamic_acid decarboxylase -LRB- GAD65 -RRB- and proinsulin in a patient with stiff-person_syndrome but without type_1_diabetes .
23228173	0	CD4	0,3	GAD65	47,52	CD4	GAD65	920	2572	Gene	Gene	cells|compound|START_ENTITY recognize|nsubj|cells recognize|dobj|epitopes epitopes|nmod|END_ENTITY	CD4 + T cells recognize diverse epitopes within GAD65 : implications for repertoire development and diabetes monitoring .
25405480	0	CD4	14,17	GAD65	119,124	CD4	GAD65	920	2572	Gene	Gene	Responses|compound|START_ENTITY Assessment|nmod|Responses Reveals|nsubj|Assessment Reveals|dobj|Role Role|nmod|END_ENTITY	Assessment of CD4 + T Cell Responses to Glutamic_Acid Decarboxylase 65 Using DQ8 Tetramers Reveals a Pathogenic Role of GAD65 121-140 and GAD65 250-266 in T1D Development .
25681349	0	CD4	73,76	GAD65	40,45	CD4	GAD65	920	2572	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	High Diversity in the TCR Repertoire of GAD65 Autoantigen-Specific Human CD4 + T Cells .
26797873	0	CD4	110,113	GAD65	56,61	CD4	GAD65	12504(Tax:10090)	14417(Tax:10090)	Gene	Gene	Vaccination|nsubj|START_ENTITY Vaccination|nmod|DNA DNA|acl|plasmid plasmid|xcomp|containing containing|dobj|gene gene|amod|END_ENTITY	Vaccination with a co-expression DNA plasmid containing GAD65 fragment gene and IL-10 gene induces regulatory CD4 -LRB- + -RRB- T cells that prevent experimental autoimmune diabetes .
15947486	0	CD4	45,48	GATA-3	8,14	CD4	GATA-3	920	2625	Gene	Gene	cells|nummod|START_ENTITY transcription|nmod|cells transcription|nsubj|Role Role|nmod|END_ENTITY	Role of GATA-3 in IL-5 gene transcription by CD4 + T cells of asthmatic patients .
18776904	0	CD4	104,107	GATA-3	49,55	CD4	GATA-3	920	2625	Gene	Gene	differentiation|nmod|START_ENTITY functions|nmod|differentiation functions|nmod|END_ENTITY	Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4 -LRB- + -RRB- T cells .
21357543	0	CD4	39,42	GATA-3	14,20	CD4	GATA-3	920	2625	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of GATA-3 expression during CD4 lineage differentiation .
21625544	0	CD4	13,16	GATA-3	47,53	CD4	GATA-3	12504(Tax:10090)	14462(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Expansion|nmod|CD25 Expansion|appos|cells cells|compound|END_ENTITY	Expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- and CD25 -LRB- - -RRB- T-Bet , GATA-3 , Foxp3 and RORyt cells in allergic_inflammation , local lung distribution and chemokine gene expression .
24099613	0	CD4	52,55	GATA-3	70,76	CD4	GATA-3	920	2625	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|deficient deficient|nsubj|END_ENTITY	All-transretinoic_acid regulates Th1/Th2 balance in CD4 + T cells when GATA-3 is deficient .
9160750	0	CD4	96,99	GATA-3	25,31	CD4	GATA-3	12504(Tax:10090)	14462(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells necessary|nmod|expression necessary|nsubj|END_ENTITY	The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells .
15249593	0	CD4	59,62	GITR	0,4	CD4	GITR	920	8784	Gene	Gene	effect|nmod|START_ENTITY induces|dobj|effect induces|nsubj|activation activation|amod|END_ENTITY	GITR activation induces an opposite effect on alloreactive CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells in graft-versus-host_disease .
17391121	0	CD4	58,61	GITR	0,4	CD4	GITR	12504(Tax:10090)	21936(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY allograft|nmod|cells allograft|nsubj|blocks blocks|amod|END_ENTITY	GITR ligation blocks allograft protection by induced CD25 + CD4 + regulatory T cells without enhancing effector T-cell function .
18930767	0	CD4	21,24	GITR	63,67	CD4	GITR	12504(Tax:10090)	21936(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ mediated|nmod|expansion mediated|nmod|molecules molecules|amod|END_ENTITY	In vivo expansion of CD4 + Foxp3 + regulatory T cells mediated by GITR molecules .
19417739	0	CD4	46,49	GITR	97,101	CD4	GITR	12504(Tax:10090)	21936(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY immunity|nmod|T-cell transfer|nsubj|immunity transfer|nmod|ligation ligation|compound|END_ENTITY	Therapeutic immunity by adoptive_tumor-primed CD4 -LRB- + -RRB- T-cell transfer in combination with in vivo GITR ligation .
20139172	0	CD4	80,83	GITR	0,4	CD4	GITR	12504(Tax:10090)	21936(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhances|dobj|proliferation enhances|nsubj|engagement engagement|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
21557210	0	CD4	0,3	GITR	17,21	CD4	GITR	920	8784	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21557210	0	CD4	46,49	GITR	17,21	CD4	GITR	920	8784	Gene	Gene	population|compound|START_ENTITY cells|dep|population cells|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
22317750	0	CD4	40,43	GITR	61,65	CD4	GITR	12504(Tax:10090)	21936(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY function|nmod|CD25 T|nsubj|function T|nsubj|+ +|amod|END_ENTITY	Increased immunosuppressive function of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- GITR + T regulatory cells from NFATc2 -LRB- -LRB- - / - -RRB- -RRB- mice controls allergen-induced experimental asthma .
25256257	0	CD4	42,45	GITR	24,28	CD4	GITR	920	8784	Gene	Gene	cells|nummod|START_ENTITY Expansion|dep|cells Expansion|nmod|/ /|compound|END_ENTITY	Expansion of regulatory GITR + CD25 Low / - CD4 + T cells in systemic_lupus_erythematosus patients .
22859956	0	CD4	31,34	GLI2	0,4	CD4	GLI2	920	2736	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	GLI2 regulates TGF-b1 in human CD4 + T cells : implications in cancer and HIV pathogenesis .
10760792	0	CD4	158,161	GM-CSF	32,38	CD4	GM-CSF	12504(Tax:10090)	12981(Tax:10090)	Gene	Gene	anergy|compound|START_ENTITY induce|dobj|anergy cells|acl:relcl|induce generates|dobj|cells generates|nsubj|Culture Culture|nmod|cells cells|nmod|END_ENTITY	Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro .
1354325	0	CD4	21,24	GM-CSF	0,6	CD4	GM-CSF	920	1437	Gene	Gene	T-lymphocytes|compound|START_ENTITY production|nmod|T-lymphocytes production|amod|END_ENTITY	GM-CSF production by CD4 + T-lymphocytes is selectively impaired during the course of HIV-1_infection .
18603443	0	CD4	36,39	GM-CSF	108,114	CD4	GM-CSF	920	1437	Gene	Gene	+|compound|START_ENTITY coexpress|nsubj|+ coexpress|xcomp|END_ENTITY	Mycobacterium_tuberculosis-specific CD4 + , IFNgamma + , and TNFalpha + multifunctional memory T cells coexpress GM-CSF .
19171501	0	CD4	130,133	GM-CSF	86,92	CD4	GM-CSF	12504(Tax:10090)	12981(Tax:10090)	Gene	Gene	function|compound|START_ENTITY type|nmod|function type|nsubj|Modulation Modulation|nmod|cells cells|acl|using using|dobj|delays delays|appos|END_ENTITY	Modulation of dendritic cells using granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- delays type 1 diabetes by enhancing CD4 + CD25 + regulatory T cell function .
21931646	0	CD4	92,95	GM-CSF	0,6	CD4	GM-CSF	920	1437	Gene	Gene	cells|compound|START_ENTITY recognized|nmod|cells antigens|acl|recognized identification|nmod|antigens allows|dobj|identification allows|nsubj|production production|amod|END_ENTITY	GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4 + T cells following smallpox vaccination .
22345669	0	CD4	65,68	GM-CSF	55,61	CD4	GM-CSF	920	1437	Gene	Gene	cells|amod|START_ENTITY regulates|nmod|cells regulates|dobj|production production|nmod|END_ENTITY	Inflammasome-derived IL-1b regulates the production of GM-CSF by CD4 -LRB- + -RRB- T cells and y T cells .
25773153	0	CD4	21,24	GM-CSF	0,6	CD4	GM-CSF	920	1437	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|amod|END_ENTITY	GM-CSF production by CD4 -LRB- + -RRB- T cells in MS patients : Regulation by regulatory T cells and vitamin D. BACKGROUND/OBJECTIVE : Data from animal models of MS suggest that GM-CSF -LRB- + -RRB- CD4 -LRB- + -RRB- T cells are pathogenic cells .
26448779	0	CD4	109,112	GM-CSF	91,97	CD4	GM-CSF	24932(Tax:10116)	116630(Tax:10116)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Aging diminishes the resistance of AO rats to EAE : putative role of enhanced generation of GM-CSF Expressing CD4 + T cells in aged rats .
10708050	0	CD4	105,108	GP120	38,43	CD4	GP120	920	3700	Gene	Gene	clones|compound|START_ENTITY response|nmod|clones antagonize|dobj|response epitope|xcomp|antagonize epitope|nsubj|peptides peptides|nmod|T-helper T-helper|compound|END_ENTITY	Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones .
11906183	0	CD4	8,11	GP120	28,33	CD4	GP120	920	3700	Gene	Gene	Role|nmod|START_ENTITY hinge|nsubj|Role hinge|nmod|utilization utilization|compound|END_ENTITY	Role of CD4 hinge region in GP120 utilization by immunoglobulin domain 1 .
3264307	0	CD4	37,40	GP120	20,25	CD4	GP120	920	3700	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of GP120 binding to CD4 and an assay that measures ability of sera to inhibit this binding .
22438246	0	CD4	52,55	Galectin-9	0,10	CD4	Galectin-9	920	3965	Gene	Gene	cells|compound|START_ENTITY susceptible|nsubj|cells activated|xcomp|susceptible activated|nsubj|renders renders|amod|END_ENTITY	Galectin-9 binding to Tim-3 renders activated human CD4 + T cells less susceptible to HIV-1_infection .
23310955	0	CD4	54,57	Gata3	41,46	CD4	Gata3	920	2625	Gene	Gene	T-cell|compound|START_ENTITY END_ENTITY|nmod|T-cell	Thpok-independent repression of Runx3 by Gata3 during CD4 + T-cell differentiation in the thymus .
18034420	0	CD4	68,71	Gfi1	53,57	CD4	Gfi1	920	2672	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential impact of the transcriptional repressor Gfi1 on mature CD4 + and CD8 + T lymphocyte function .
26749286	0	CD4	104,107	Gfi1	0,4	CD4	Gfi1	12504(Tax:10090)	14581(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Gfi1 , a transcriptional repressor , inhibits the induction of the T helper type 1 programme in activated CD4 T cells .
10482842	0	CD4	41,44	Gonadotropin-releasing_hormone	0,30	CD4	Gonadotropin-releasing hormone	24932(Tax:10116)	25194(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Gonadotropin-releasing_hormone increases CD4 T-lymphocyte numbers in an animal model of immunodeficiency .
11517385	0	CD4	55,58	Gp120	0,5	CD4	Gp120	920	3700	Gene	Gene	cells|nmod|START_ENTITY activates|dobj|cells activates|nsubj|END_ENTITY	Gp120 activates children 's brain endothelial cells via CD4 .
1933287	0	CD4	79,82	Gp120	56,61	CD4	Gp120	920	3700	Gene	Gene	antigen|compound|START_ENTITY END_ENTITY|acl:relcl|antigen	Brain-derived cells contain a specific binding site for Gp120 which is not the CD4 antigen .
8663408	0	CD4	78,81	Gp120	61,66	CD4	Gp120	920	3700	Gene	Gene	binds|dobj|START_ENTITY domain|acl:relcl|binds domain|nmod|END_ENTITY	A synthetic conformational epitope from the C4 domain of HIV Gp120 that binds CD4 .
19616200	0	CD4	11,14	GrB	73,76	CD4	GrB	920	3002	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
25967708	0	CD4	21,24	HIF-1a	54,60	CD4	HIF-1a	920	3091	Gene	Gene	Treg|compound|START_ENTITY Relationship|nmod|Treg Relationship|nmod|END_ENTITY	Relationship between CD4 + CD25 + Treg and expression of HIF-1a and Ki-67 in NSCLC patients .
26150319	0	CD4	45,48	HIF-1a	24,30	CD4	HIF-1a	920	3091	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Transcription regulates HIF-1a expression in CD4 -LRB- + -RRB- T cells .
24931519	0	CD4	39,42	HIF1a	10,15	CD4	HIF1a	920	3091	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 END_ENTITY|nmod|expression	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
11207664	0	CD4	0,3	HLA-B27	105,112	CD4	HLA-B27	920	3106	Gene	Gene	+|compound|START_ENTITY indicate|nsubj|+ indicate|parataxis|+ +|nsubj|study study|nmod|END_ENTITY	CD4 + and CD8 + clonal T cell expansions indicate a role of antigens in ankylosing_spondylitis ; a study in HLA-B27 + monozygotic twins .
11509603	0	CD4	36,39	HLA-B27	19,26	CD4	HLA-B27	920	3106	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	The recognition of HLA-B27 by human CD4 -LRB- + -RRB- T lymphocytes .
12626789	0	CD4	65,68	HLA-B27	54,61	CD4	HLA-B27	920	3106	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Breaking the rules : the unconventional recognition of HLA-B27 by CD4 + T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies .
16476051	0	CD4	35,38	HLA-B27	60,67	CD4	HLA-B27	24932(Tax:10116)	3106	Gene	Gene	responses|compound|START_ENTITY responses|nmod|rats rats|amod|transgenic transgenic|amod|END_ENTITY	Luminal bacterial antigen-specific CD4 + T-cell responses in HLA-B27 transgenic rats with chronic_colitis are mediated by both major histocompatibility class II and HLA-B27 molecules .
20350610	0	CD4	89,92	HLA-DPB1	0,8	CD4	HLA-DPB1	920	3115	Gene	Gene	responses|compound|START_ENTITY repertoire|nmod|responses generation|nmod|repertoire showing|nsubj|generation mismatching|advcl|showing END_ENTITY|acl|mismatching	HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4 + T cell responses showing immunogenicity of all HLA-DPB1 alleles .
20350610	0	CD4	89,92	HLA-DPB1	141,149	CD4	HLA-DPB1	920	3115	Gene	Gene	responses|compound|START_ENTITY repertoire|nmod|responses generation|nmod|repertoire showing|nsubj|generation showing|dobj|immunogenicity immunogenicity|nmod|END_ENTITY	HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4 + T cell responses showing immunogenicity of all HLA-DPB1 alleles .
21760531	0	CD4	83,86	HLA-DPB1	21,29	CD4	HLA-DPB1	920	3115	Gene	Gene	T|compound|START_ENTITY recognized|nmod|T END_ENTITY|ccomp|recognized	Identification of an HLA-DPB1 * 0501 restricted Melan-A/MART -1 epitope recognized by CD4 + T lymphocytes : prevalence for immunotherapy in Asian populations .
23502763	0	CD4	58,61	HLA-DPB1	0,8	CD4	HLA-DPB1	920	3115	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	HLA-DPB1 * 05 : 01-restricted WT1332-specific TCR-transduced CD4 + T lymphocytes display a helper activity for WT1-specific CTL induction and a cytotoxicity against leukemia cells .
10996380	0	CD4	34,37	HLA-G	0,5	CD4	HLA-G	920	3135	Gene	Gene	T-lymphocytes|compound|START_ENTITY proliferation|nmod|T-lymphocytes suppresses|dobj|proliferation suppresses|nsubj|END_ENTITY	HLA-G suppresses proliferation of CD4 -LRB- + -RRB- T-lymphocytes .
11572934	0	CD4	107,110	HLA-G	8,13	CD4	HLA-G	920	3135	Gene	Gene	cell|compound|START_ENTITY response|dep|cell suppresses|dobj|response suppresses|nsubj|protein protein|amod|END_ENTITY	Soluble HLA-G protein secreted by allo-specific CD4 + T cells suppresses the allo-proliferative response : a CD4 + T cell regulatory mechanism .
11572934	0	CD4	48,51	HLA-G	8,13	CD4	HLA-G	920	3135	Gene	Gene	cells|compound|START_ENTITY secreted|nmod|cells protein|acl|secreted protein|amod|END_ENTITY	Soluble HLA-G protein secreted by allo-specific CD4 + T cells suppresses the allo-proliferative response : a CD4 + T cell regulatory mechanism .
14991594	0	CD4	13,16	HLA-G	62,67	CD4	HLA-G	920	3135	Gene	Gene	+|compound|START_ENTITY express|nsubj|+ express|dobj|molecule molecule|amod|END_ENTITY	Alloreactive CD4 + and CD8 + T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions : in vivo implications in transplanted patients .
15652415	0	CD4	64,67	HLA-G	17,22	CD4	HLA-G	920	3135	Gene	Gene	activation|compound|START_ENTITY inhibitor|nmod|activation acts|nmod|inhibitor acts|nsubj|END_ENTITY	Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo : rationale for the therapy of multiple_sclerosis .
23220581	0	CD4	72,75	HLA-G	8,13	CD4	HLA-G	920	3135	Gene	Gene	lymphocytes|compound|START_ENTITY modulates|nmod|lymphocytes modulates|nsubj|END_ENTITY	Soluble HLA-G modulates miRNA-210 and miRNA-451 expression in activated CD4 + T lymphocytes .
24744146	0	CD4	6,9	HLA-G	11,16	CD4	HLA-G	920	3135	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + HLA-G + regulatory T cells are potent suppressors of graft-versus-host_disease in vivo .
19295543	0	CD4	37,40	HLA_DQB1	23,31	CD4	HLA DQB1	920	3119	Gene	Gene	T-cell|compound|START_ENTITY END_ENTITY|nmod|T-cell	Genetic association of HLA_DQB1 with CD4 + CD25 + -LRB- high -RRB- T-cell apoptosis in type 1 diabetes .
17237417	0	CD4	117,120	HSP70	75,80	CD4	HSP70	920	3308	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4 -LRB- + -RRB- T cells and dendritic cells .
23300563	0	CD4	45,48	HSP70	0,5	CD4	HSP70	920	3308	Gene	Gene	CD25|compound|START_ENTITY function|nmod|CD25 enhances|dobj|function enhances|nsubj|END_ENTITY	HSP70 enhances immunosuppressive function of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T regulatory cells and cytotoxicity in CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells .
26452441	0	CD4	59,62	Heat_Shock_Protein_60	29,50	CD4	Heat Shock Protein 60	12504(Tax:10090)	15510(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intranasal Immunization with Heat_Shock_Protein_60 Induces CD4 + CD25 + GARP + and Type-1 Regulatory T Cells and Inhibits Early Atherosclerosis .
26495986	0	CD4	122,125	Helios	35,41	CD4	Helios	12504(Tax:10090)	22779(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Thymus-Derived|nmod|Cells Do|dobj|Thymus-Derived Do|nsubj|Differences Differences|nmod|Level Level|nmod|END_ENTITY	Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4 + Foxp3 + Regulatory T Cells .
19797297	0	CD4	54,57	Heme_oxygenase_1	17,33	CD4	Heme oxygenase 1	920	3162	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Pivotal Advance : Heme_oxygenase_1 expression by human CD4 + T cells is not sufficient for their development of immunoregulatory capacity .
16245362	0	CD4	78,81	Hsp70	23,28	CD4	Hsp70	920	3308	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhances|dobj|proliferation enhances|nsubj|END_ENTITY	The heat_shock protein Hsp70 enhances antigen-specific proliferation of human CD4 + memory T cells .
21170379	0	CD4	80,83	Hsp70	58,63	CD4	Hsp70	12504(Tax:10090)	15511(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY dependent|nmod|cells dependent|nsubj|survival survival|nmod|allografts allografts|acl|induced induced|nmod|END_ENTITY	Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4 + CD25 + regulatory T cells .
27014269	0	CD4	50,53	Hsp70	125,130	CD4	Hsp70	12504(Tax:10090)	15511(Tax:10090)	Gene	Gene	T|compound|START_ENTITY Mouse|nmod|T Generation|nmod|Mouse Cells|nsubj|Generation Cells|xcomp|Recognizing Recognizing|dobj|Peptide Peptide|compound|END_ENTITY	Generation of the First TCR Transgenic Mouse with CD4 -LRB- + -RRB- T Cells Recognizing an Anti-inflammatory Regulatory T Cell-Inducing Hsp70 Peptide .
24477678	0	CD4	55,58	HuR	48,51	CD4	HuR	12504(Tax:10090)	15568(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Conditional knockout of the RNA-binding protein HuR in CD4 T cells reveals a gene dosage effect on cytokine production .
10342043	0	CD4	52,55	ICAM-1	43,49	CD4	ICAM-1	920	3383	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Soluble intercellular adhesion molecule-1 -LRB- ICAM-1 -RRB- , CD4 , CD8 and interleukin-2 receptor in patients with Beh __ et 's _ disease and Vogt-Koyanagi-Harada 's _ disease .
1347547	1	CD4	88,91	ICAM-1	164,170	CD4	ICAM-1	920	3383	Gene	Gene	cells|compound|START_ENTITY require|nsubj|cells require|dobj|signal signal|acl|mediated mediated|nmod|pathway pathway|compound|END_ENTITY	Naive CD4 +45 RA + T cells require a costimulatory signal mediated through the LFA-1 / ICAM-1 pathway .
12538658	0	CD4	35,38	ICOS	14,18	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY defines|dobj|cells defines|nsubj|Expression Expression|nmod|END_ENTITY	Expression of ICOS in vivo defines CD4 + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin_10 .
15184501	0	CD4	0,3	ICOS	42,46	CD4	ICOS	920	29851	Gene	Gene	cells|compound|START_ENTITY cells|amod|dependent dependent|nmod|END_ENTITY	CD4 + CD25 + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic_lesion .
15361696	0	CD4	84,87	ICOS	19,23	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	Th1|compound|START_ENTITY END_ENTITY|nmod|Th1	Role of the B7RP-1 / ICOS pathway in renal tubular epithelial antigen presentation to CD4 + Th1 and Th2 cells .
16500623	0	CD4	30,33	ICOS	16,20	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Upregulation of ICOS on CD43 + CD4 + murine small intestinal intraepithelial lymphocytes during acute reovirus_infection .
16751384	0	CD4	66,69	ICOS	20,24	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY mediated|nmod|cells mediated|nsubj|effects effects|nmod|END_ENTITY	Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells .
17549732	0	CD4	39,42	ICOS	12,16	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	help|compound|START_ENTITY development|nmod|help END_ENTITY|nmod|development	The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells .
18292519	0	CD4	50,53	ICOS	14,18	CD4	ICOS	920	29851	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Expression of ICOS on human melanoma-infiltrating CD4 + CD25highFoxp3 + T regulatory cells : implications and impact on tumor-mediated immune suppression .
18310064	0	CD4	0,3	ICOS	4,8	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + ICOS + T lymphocytes inhibit T cell activation ` in vitro ' and attenuate autoimmune_encephalitis ` in vivo ' .
18941193	0	CD4	156,159	ICOS	161,165	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
19376499	0	CD4	78,81	ICOS	47,51	CD4	ICOS	920	29851	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T-cell dysfunction in patients with active SLE .
19448155	0	CD4	17,20	ICOS	32,36	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
20116985	0	CD4	14,17	ICOS	85,89	CD4	ICOS	920	29851	Gene	Gene	activation|compound|START_ENTITY Regulation|nmod|activation function|nsubj|Regulation function|nmod|inducible_costimulator inducible_costimulator|appos|END_ENTITY	Regulation of CD4 T cell activation and effector function by inducible_costimulator -LRB- ICOS -RRB- .
21364749	0	CD4	27,30	ICOS	49,53	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY depend|nsubj|cells depend|nmod|END_ENTITY	Protective effector memory CD4 T cells depend on ICOS for survival .
21558138	0	CD4	21,24	ICOS	26,30	CD4	ICOS	920	29851	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
22371394	0	CD4	0,3	ICOS	33,37	CD4	ICOS	920	29851	Gene	Gene	type|nsubj|START_ENTITY type|ccomp|mediate mediate|dobj|END_ENTITY	CD4 -LRB- + -RRB- type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes .
22661090	0	CD4	26,29	ICOS	121,125	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY analysis|nmod|cells reveals|nsubj|analysis reveals|dobj|role role|nmod|END_ENTITY	Comprehensive analysis of CD4 + T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS .
22815292	0	CD4	45,48	ICOS	0,4	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY generation|nmod|Foxp3 mediates|dobj|generation mediates|nsubj|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
23316652	0	CD4	36,39	ICOS	28,32	CD4	ICOS	920	29851	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	-LSB- Expression and function of ICOS on CD4 T cells and application to therapy in patients with ocular Beh __ et 's _ disease with uveitis -RSB- .
23802069	0	CD4	110,113	ICOS	0,4	CD4	ICOS	920	29851	Gene	Gene	T|compound|START_ENTITY amplification|nmod|T cells|compound|amplification promotes|dobj|cells associated|advcl|promotes associated|nsubjpass|END_ENTITY	ICOS is associated with poor prognosis in breast_cancer as it promotes the amplification of immunosuppressive CD4 -LRB- + -RRB- T cells by plasmacytoid dendritic cells .
23923047	0	CD4	61,64	ICOS	53,57	CD4	ICOS	920	29851	Gene	Gene	cells|compound|START_ENTITY differentiation|dep|cells differentiation|nmod|END_ENTITY	STAT3 signaling induces the differentiation of human ICOS -LRB- + -RRB- CD4 T cells helping B lymphocytes .
24312642	0	CD4	52,55	ICOS	0,4	CD4	ICOS	920	29851	Gene	Gene	Treg|compound|START_ENTITY generation|nmod|Treg regulates|dobj|generation regulates|nsubj|END_ENTITY	ICOS regulates the generation and function of human CD4 + Treg in a CTLA-4 dependent manner .
25754933	0	CD4	65,68	ICOS	0,4	CD4	ICOS	12504(Tax:10090)	54167(Tax:10090)	Gene	Gene	populations|amod|START_ENTITY generation|nmod|populations required|nmod|generation required|nsubjpass|END_ENTITY	ICOS is required for the generation of both central and effector CD4 -LRB- + -RRB- memory T-cell populations following acute bacterial_infection .
25918344	0	CD4	44,47	ICOS	0,4	CD4	ICOS	404704(Tax:9823)	733597(Tax:9823)	Gene	Gene	population|compound|START_ENTITY maintain|dobj|population maintain|nsubj|END_ENTITY	ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis .
25918344	0	CD4	44,47	ICOS	0,4	CD4	ICOS	404704(Tax:9823)	733597(Tax:9823)	Gene	Gene	population|compound|START_ENTITY maintain|dobj|population maintain|nsubj|END_ENTITY	ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis .
25363454	0	CD4	30,33	IFI16	16,21	CD4	IFI16	920	3428	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Polymorphism in IFI16 affects CD4 -LRB- + -RRB- T-cell counts in HIV-1_infection .
10047431	0	CD4	5,8	IFN-gamma	46,55	CD4	IFN-gamma	24932(Tax:10116)	25712(Tax:10116)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|required required|nmod|expression expression|amod|END_ENTITY	Both CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells are required for IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats .
10072538	0	CD4	98,101	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY depleted|nmod|cells mice|acl|depleted restore|nmod|mice +|ccomp|restore +|nsubj|END_ENTITY	IFN-gamma and CD8 + T cells restore host defenses against Pneumocystis_carinii in mice depleted of CD4 + T cells .
10220431	0	CD4	0,3	IFN-gamma	94,103	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|mediated mediated|nmod|END_ENTITY	CD4 -LRB- + -RRB- T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma .
10403909	0	CD4	60,63	IFN-gamma	35,44	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nsubj|IL-4 IL-4|appos|END_ENTITY	Reduced IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- expression by CD4 T cells in patients with chronic_lymphocytic_leukaemia .
10411927	0	CD4	0,3	IFN-gamma	91,100	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|eliminate eliminate|nmod|effects effects|nmod|END_ENTITY	CD4 -LRB- + -RRB- T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma .
10454344	0	CD4	107,110	IFN-gamma	146,155	CD4	IFN-gamma	407098(Tax:9913)	281237(Tax:9913)	Gene	Gene	+|compound|START_ENTITY responses|nmod|+ interleukin-12|nmod|responses effects|nmod|interleukin-12 T|nsubj|effects T|parataxis|enhances enhances|dobj|production production|amod|END_ENTITY	Comparative effects of interleukin-12 and interleukin-4 on cytokine responses by antigen-stimulated memory CD4 + T cells of cattle : IL-12 enhances IFN-gamma production , whereas IL-4 has marginal effects on cytokine expression .
10540183	0	CD4	19,22	IFN-gamma	55,64	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|cells cells|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	In vitro activated CD4 + T cells from interferon-gamma -LRB- IFN-gamma -RRB- - deficient mice induce intestinal_inflammation in immunodeficient hosts .
10590258	0	CD4	0,3	IFN-gamma	169,178	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|dobj|cells cells|acl|induced induced|xcomp|expressing expressing|ccomp|epitope epitope|nmod|production production|amod|END_ENTITY	CD4 -LRB- + -RRB- T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p_1 independently of IFN-gamma production .
10944605	0	CD4	41,44	IFN-gamma	23,32	CD4	IFN-gamma	920	3458	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Enhanced expression of IFN-gamma mRNA in CD4 -LRB- + -RRB- or CD8 -LRB- + -RRB- tumour-infiltrating lymphocytes compared to peripheral lymphocytes in patients with renal_cell_cancer .
11123297	0	CD4	55,58	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generated|nmod|cells generated|nsubj|production production|amod|END_ENTITY	IFN-gamma production by Th1 cells generated from naive CD4 + T cells exposed to norepinephrine .
11160282	0	CD4	75,78	IFN-gamma	121,130	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY angiogenesis|nmod|cells inhibition|nmod|angiogenesis requires|nsubj|inhibition requires|nmod|END_ENTITY	IFN-gamma-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4 + T cells requires tumor responsiveness to IFN-gamma .
11207279	0	CD4	111,114	IFN-gamma	55,64	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ develop|nmod|cells +|acl:relcl|develop +|nmod|rejection rejection|nmod|absence absence|nmod|END_ENTITY	Immunobiology of allograft rejection in the absence of IFN-gamma : CD8 + effector cells develop independently of CD4 + cells and CD40-CD40 ligand interactions .
11359851	0	CD4	27,30	IFN-gamma	134,143	CD4	IFN-gamma	920	3458	Gene	Gene	cells|nummod|START_ENTITY CCR4|nmod|cells defines|nsubj|CCR4 defines|dobj|subset subset|dep|ratios ratios|amod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11380148	0	CD4	112,115	IFN-gamma	81,90	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Non-M protein -LRB- s -RRB- on the cell wall and membrane of group A streptococci induce -LRB- s -RRB- IFN-gamma production by dermal CD4 + T cells in psoriasis .
11465110	0	CD4	90,93	IFN-gamma	66,75	CD4	IFN-gamma	920	3458	Gene	Gene	lymphocytes|compound|START_ENTITY induces|nmod|lymphocytes induces|dobj|production production|amod|END_ENTITY	Neonatal bacillus Calmette-Gu rin vaccination induces adult-like IFN-gamma production by CD4 + T lymphocytes .
11591752	0	CD4	114,117	IFN-gamma	149,158	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|dobj|proliferation proliferation|nmod|mechanism mechanism|amod|END_ENTITY	A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1 -LRB- + -RRB- macrophages that suppress naive CD4 -LRB- + -RRB- T cell proliferation via an IFN-gamma and nitric_oxide-dependent mechanism .
11673565	0	CD4	49,52	IFN-gamma	6,15	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|compound|START_ENTITY critical|nmod|T rejection|amod|critical rejection|nsubj|receptors receptors|compound|END_ENTITY	Donor IFN-gamma receptors are critical for acute CD4 -LRB- + -RRB- T cell-mediated cardiac allograft rejection .
11971011	0	CD4	72,75	IFN-gamma	138,147	CD4	IFN-gamma	920	15978(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY production|nmod|homolog T|nsubj|production T|dobj|cells cells|nmod|mice mice|acl|treated treated|nmod|antibodies antibodies|amod|END_ENTITY	Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4 -LRB- + -RRB- T cells in resistant mice treated once with anti-IL-12 or - IFN-gamma antibodies at the onset of infection with Leishmania_major instructs Th2 cell development , resulting in nonhealing lesions .
12060463	0	CD4	46,49	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY important|nmod|activation important|nsubj|END_ENTITY	IFN-gamma but not IL-4 is important for mouse CD4 + T cell-mediated macrophage activation following their exposure to pig cells in vitro .
12444170	0	CD4	62,65	IFN-gamma	37,46	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY Th2|acl:relcl|cell Th2|appos|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12496425	0	CD4	6,9	IFN-gamma	180,189	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY mobilized|nsubjpass|cells mobilized|xcomp|kill kill|nmod|effects effects|nmod|END_ENTITY	Human CD4 + T cells present within the microenvironment of human lung_tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-gamma .
12697666	0	CD4	95,98	IFN-gamma	135,144	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|compound|START_ENTITY subunits|nmod|T Clustering|dobj|subunits signal|dep|Clustering signal|nmod|production production|amod|END_ENTITY	Clustering of immunoreceptor tyrosine-based activation motif-containing signalling subunits in CD4 -LRB- + -RRB- T cells is an optimal signal for IFN-gamma production , but not for the production of IL-4 .
12902481	0	CD4	60,63	IFN-gamma	39,48	CD4	IFN-gamma	395362(Tax:9031)	396054(Tax:9031)	Gene	Gene	cells|nummod|START_ENTITY release|nmod|cells release|amod|END_ENTITY	IL-18 stimulates the proliferation and IFN-gamma release of CD4 + T cells in the chicken : conservation of a Th1-like system in a nonmammalian species .
12902504	0	CD4	115,118	IFN-gamma	86,95	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	DNA vaccines , combining form of antigen and method of delivery to raise a spectrum of IFN-gamma and IL-4-producing CD4 + and CD8 + T cells .
1354229	0	CD4	86,89	IFN-gamma	8,17	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY depleted|nmod|cells mice|acl|depleted lymphokine|nmod|mice lymphokine|nsubj|END_ENTITY	Altered IFN-gamma and IL-4 pattern lymphokine secretion in mice partially depleted of CD4 T cells by anti-CD4 monoclonal antibody .
14734762	0	CD4	96,99	IFN-gamma	72,81	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ down-regulation|dep|cells down-regulation|nmod|production production|amod|END_ENTITY	Overproduction of TNF-alpha by CD8 + type 1 cells and down-regulation of IFN-gamma production by CD4 + Th1 cells contribute to toxic_shock-like_syndrome in an animal model of fatal monocytotropic ehrlichiosis .
15003314	0	CD4	53,56	IFN-gamma	88,97	CD4	IFN-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY Isolation|nmod|+ T|nsubj|Isolation T|nmod|secretion secretion|amod|END_ENTITY	Isolation and expansion of human adenovirus-specific CD4 + and CD8 + T cells according to IFN-gamma secretion for adjuvant immunotherapy .
15153508	0	CD4	27,30	IFN-gamma	14,23	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia_infection .
15373901	0	CD4	0,3	IFN-gamma	22,31	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|producing producing|dobj|END_ENTITY	CD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotype .
15388256	0	CD4	124,127	IFN-gamma	15,24	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY increase|nmod|+ characterized|nmod|increase infection|acl|characterized responses|nmod|infection leads|nmod|responses leads|nsubj|absence absence|nmod|END_ENTITY	The absence of IFN-gamma leads to increased Th2 responses after influenza_A_virus infection characterized by an increase in CD4 + but not CD8 + T cells producing IL-4 or IL-5 in the lung .
15451617	0	CD4	14,17	IFN-gamma	28,37	CD4	IFN-gamma	493775(Tax:9685)	493965(Tax:9685)	Gene	Gene	+|compound|START_ENTITY Assessment|nmod|+ +|nsubj|Assessment +|dobj|cells cells|amod|END_ENTITY	Assessment of CD4 + and CD8 + IFN-gamma producing cells by ELISPOT in na ve and FIV-infected cats .
15611472	0	CD4	34,37	IFN-gamma	50,59	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|mice mice|amod|END_ENTITY	Impaired up-regulation of CD25 on CD4 + T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart_failure .
15634932	0	CD4	73,76	IFN-gamma	42,51	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4 + T cells .
15743488	0	CD4	10,13	IFN-gamma	150,159	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	functioning|compound|START_ENTITY functioning|dep|factor factor|nmod|pathogenesis pathogenesis|acl|counter-regulated counter-regulated|nmod|END_ENTITY	Defective CD4 + CD25 + regulatory T cell functioning in collagen-induced_arthritis : an important factor in pathogenesis , counter-regulated by endogenous IFN-gamma .
15814693	0	CD4	66,69	IFN-gamma	97,106	CD4	IFN-gamma	920	3458	Gene	Gene	alloproliferation|compound|START_ENTITY alloproliferation|dep|responses responses|amod|END_ENTITY	IL-12-independent LIGHT signaling enhances MHC class II disparate CD4 + T cell alloproliferation , IFN-gamma responses , and intestinal_graft-versus-host_disease .
15879087	0	CD4	71,74	IFN-gamma	47,56	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	TGF-beta_1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4 + T cells at priming and at recall : differential involvement of Stat4 and T-bet .
15935691	0	CD4	77,80	IFN-gamma	52,61	CD4	IFN-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|appos|END_ENTITY	Correlation between intracellular interferon-gamma -LRB- IFN-gamma -RRB- production by CD4 + and CD8 + lymphocytes and IFN-gamma gene polymorphism in patients with type 2 diabetes_mellitus and latent autoimmune diabetes of adults -LRB- LADA -RRB- .
15935883	0	CD4	101,104	IFN-gamma	40,49	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY effect|nmod|cells regulating|dobj|effect controls|advcl|regulating controls|dobj|production production|amod|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
16002150	0	CD4	34,37	IFN-gamma	124,133	CD4	IFN-gamma	24932(Tax:10116)	25712(Tax:10116)	Gene	Gene	T|compound|START_ENTITY Activation|nmod|T cells|amod|Activation marrow-derived|nsubj|cells marrow-derived|ccomp|induces induces|dobj|secretion secretion|nmod|END_ENTITY	Activation of purified allogeneic CD4 -LRB- + -RRB- T cells by rat bone marrow-derived dendritic cells induces concurrent secretion of IFN-gamma , IL-4 , and IL-10 .
16034093	0	CD4	138,141	IFN-gamma	107,116	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Direct stimulation of human T cells via TLR5 and TLR7/8 : flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4 + T cells .
16177085	0	CD4	48,51	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generation/activation|nmod|cells controls|dobj|generation/activation controls|nsubj|END_ENTITY	IFN-gamma controls the generation/activation of CD4 + CD25 + regulatory T cells in antitumor immune response .
16237051	0	CD4	76,79	IFN-gamma	20,29	CD4	IFN-gamma	920	3458	Gene	Gene	responses|compound|START_ENTITY enhances|dobj|responses enhances|nsubj|signaling signaling|amod|END_ENTITY	Cutting edge : early IFN-gamma signaling directly enhances primary antiviral CD4 + T cell responses .
1670604	0	CD4	20,23	IFN-gamma	51,60	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY role|nmod|+ lymphocytes|nsubj|role lymphocytes|nmod|production production|amod|END_ENTITY	Synergistic role of CD4 + and CD8 + T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma_gondii vaccine .
1674953	1	CD4	122,125	IFN-gamma	66,75	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY necrosis|nmod|cells necrosis|nsubj|Hypersecretion Hypersecretion|nmod|END_ENTITY	Hypersecretion of IFN-gamma and tumor necrosis factor-alpha by stimulated CD4 + T cells .
16804321	0	CD4	76,79	IFN-gamma	85,94	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Delayed allergic_reaction to suxamethonium driven by oligoclonal Th1-skewed CD4 + CCR4 + IFN-gamma + memory T cells .
16849446	0	CD4	81,84	IFN-gamma	14,23	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells regulates|dobj|induction regulates|nsubj|END_ENTITY	Cutting edge : IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial_infection .
16906223	0	CD4	58,61	IFN-gamma	8,17	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Role|nmod|CD25 Role|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16906223	0	CD4	80,83	IFN-gamma	8,17	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY cells|nmod|Tregs Role|dep|cells Role|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
17075267	0	CD4	16,19	IFN-gamma	80,89	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|compound|START_ENTITY cells|nsubj|T cells|dobj|downregulation downregulation|nmod|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
17334371	0	CD4	19,22	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	loss|nummod|START_ENTITY mediates|dobj|loss mediates|nsubj|END_ENTITY	IFN-gamma mediates CD4 + T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy .
17595676	0	CD4	51,54	IFN-gamma	0,9	CD4	IFN-gamma	920	3458	Gene	Gene	lymphocytes|compound|START_ENTITY regulates|nmod|lymphocytes regulates|nsubj|END_ENTITY	IFN-gamma regulates Fas_ligand expression in human CD4 + T lymphocytes and controls their anti-mycobacterial cytotoxic functions .
17617585	0	CD4	37,40	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY acts|nmod|cells acts|nsubj|END_ENTITY	IFN-gamma acts directly on activated CD4 + T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals .
17632036	0	CD4	43,46	IFN-gamma	14,23	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY response|nmod|cells response|amod|END_ENTITY	The secretory IFN-gamma response of single CD4 memory cells after activation on different antigen presenting cell types .
17662038	0	CD4	140,143	IFN-gamma	99,108	CD4	IFN-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|amod|END_ENTITY	Staphylococcus_aureus skin colonization in atopic_dermatitis children is associated with decreased IFN-gamma production by peripheral blood CD4 + and CD8 + T cells .
17851131	0	CD4	23,26	IFN-gamma	85,94	CD4	IFN-gamma	920	3458	Gene	Gene	CD25|compound|START_ENTITY frequency|nmod|CD25 inhibit|nsubj|frequency inhibit|dobj|induction induction|nmod|cells cells|amod|END_ENTITY	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
17851131	0	CD4	98,101	IFN-gamma	85,94	CD4	IFN-gamma	920	3458	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
17923502	0	CD4	27,30	IFN-gamma	101,110	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	priming|compound|START_ENTITY regulates|dobj|priming regulates|nmod|production production|amod|END_ENTITY	TAP-1 indirectly regulates CD4 + T cell priming in Toxoplasma_gondii_infection by controlling NK cell IFN-gamma production .
17947638	0	CD4	54,57	IFN-gamma	93,102	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY promoter|nmod|cells acetylation|nmod|promoter associated|nsubjpass|acetylation associated|nmod|expression expression|amod|END_ENTITY	Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigen .
17982110	0	CD4	59,62	IFN-gamma	0,9	CD4	IFN-gamma	920	3458	Gene	Gene	T|compound|START_ENTITY produced|nmod|T cells|amod|produced cells|nummod|END_ENTITY	IFN-gamma produced by human_papilloma_virus-18 E6-specific CD4 + T cells predicts the clinical outcome after surgery in patients with high-grade cervical_lesions .
18158731	0	CD4	89,92	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY stimulation|nmod|cells found|nmod|stimulation cytokine|acl|found cytokine|nsubj|END_ENTITY	IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4 + T cells from mice immunized with a chimeric VP6 protein .
18298587	0	CD4	58,61	IFN-gamma	67,76	CD4	IFN-gamma	920	3458	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Observational support for an immunoregulatory role of CD3 + CD4 + CD25 + IFN-gamma + blood lymphocytes in kidney transplant recipients with good long-term graft outcome .
18354166	0	CD4	56,59	IFN-gamma	8,17	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells enables|dobj|expansion enables|nsubj|Loss Loss|nmod|END_ENTITY	Loss of IFN-gamma enables the expansion of autoreactive CD4 + T cells to induce experimental_autoimmune_encephalomyelitis by a nonencephalitogenic myelin variant antigen .
18388182	0	CD4	0,3	IFN-gamma	73,82	CD4	IFN-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ inhibit|nsubj|cells inhibit|advcl|produce produce|dobj|END_ENTITY	CD4 + CD25 + Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6 .
18453598	0	CD4	15,18	IFN-gamma	72,81	CD4	IFN-gamma	920	3458	Gene	Gene	frequency|compound|START_ENTITY Increasing|dobj|frequency Increasing|dep|leads leads|nmod|END_ENTITY	Increasing the CD4 + T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality .
18485335	0	CD4	84,87	IFN-gamma	52,61	CD4	IFN-gamma	920	3458	Gene	Gene	response|compound|START_ENTITY sustains|dobj|response sustains|nsubj|Expression Expression|nmod|OX40_ligand OX40_ligand|nmod|microglia microglia|acl|activated activated|nmod|END_ENTITY	Expression of OX40_ligand in microglia activated by IFN-gamma sustains a protective CD4 + T-cell response in vitro .
18802073	0	CD4	57,60	IFN-gamma	83,92	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|intestinal_inflammation intestinal_inflammation|amod|END_ENTITY	Goblet cell-derived resistin-like_molecule_beta augments CD4 + T cell production of IFN-gamma and infection-induced intestinal_inflammation .
19050105	0	CD4	99,102	IFN-gamma	0,9	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	death|compound|START_ENTITY involved|nmod|death involved|nsubjpass|expression expression|amod|END_ENTITY	IFN-gamma expression in CD8 + T cells regulated by IL-6 signal is involved in superantigen-mediated CD4 + T cell death .
19200602	0	CD4	21,24	IFN-gamma	91,100	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells requires|nsubj|activation requires|dobj|production production|amod|END_ENTITY	Mutual activation of CD4 + T cells and monocytes mediated by NKG2D-MIC interaction requires IFN-gamma production in systemic_lupus_erythematosus .
19234226	0	CD4	75,78	IFN-gamma	101,110	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	End-organ damage in a mouse_model_of_fulminant_liver_inflammation requires CD4 + T cell production of IFN-gamma but is independent of Fas .
19242516	0	CD4	72,75	IFN-gamma	95,104	CD4	IFN-gamma	920	3458	Gene	Gene	T|compound|START_ENTITY differentiation|nmod|T promote|dobj|differentiation cells|acl:relcl|promote Poly|dep|cells Poly|dep|cells cells|acl|producing producing|dobj|END_ENTITY	Poly -LRB- I : C -RRB- - Treated human langerhans cells promote the differentiation of CD4 + T cells producing IFN-gamma and IL-10 .
19535638	0	CD4	49,52	IFN-gamma	0,9	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY promotes|xcomp|cells promotes|nsubj|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19552791	0	CD4	47,50	IFN-gamma	8,17	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY associated|nsubjpass|cells associated|nmod|END_ENTITY	Reduced IFN-gamma - and enhanced IL-4-producing CD4 + cord blood T cells are associated with a higher risk for atopic_dermatitis during the first 2 yr of life .
1967279	0	CD4	14,17	IFN-gamma	92,101	CD4	IFN-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY produce|nsubj|+ produce|dobj|factor factor|compound|END_ENTITY	Host-reactive CD4 + and CD8 + T cell clones isolated from a human chimera produce IL-5 , IL-2 , IFN-gamma and granulocyte/macrophage-colony-stimulating _ factor but not IL-4 .
1972722	1	CD4	79,82	IFN-gamma	114,123	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY Frequencies|nmod|+ T|nsubj|Frequencies T|dobj|cells cells|acl:relcl|secrete secrete|dobj|END_ENTITY	Frequencies of CD4 + and CD8 + T cells that secrete IFN-gamma and IL-5 .
19741155	0	CD4	0,3	IFN-gamma	87,96	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|acl:relcl|attenuate attenuate|advcl|suppressing suppressing|dobj|production production|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells attenuate Hypersensitivity_Pneumonitis by suppressing IFN-gamma production by CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
19741155	0	CD4	111,114	IFN-gamma	87,96	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	suppressing|nmod|START_ENTITY suppressing|dobj|production production|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells attenuate Hypersensitivity_Pneumonitis by suppressing IFN-gamma production by CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
19853929	0	CD4	25,28	IFN-gamma	86,95	CD4	IFN-gamma	920	3458	Gene	Gene	CD25|compound|START_ENTITY Conversion|nmod|CD25 T|nsubj|Conversion T|nmod|CD25 CD25|nmod|cells cells|dep|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19853929	0	CD4	50,53	IFN-gamma	86,95	CD4	IFN-gamma	920	3458	Gene	Gene	CD25|compound|START_ENTITY CD25|nmod|cells cells|dep|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19877012	0	CD4	46,49	IFN-gamma	23,32	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Micro-RNA-155 inhibits IFN-gamma signaling in CD4 + T cells .
19957810	0	CD4	26,29	IFN-gamma	120,129	CD4	IFN-gamma	920	3458	Gene	Gene	CD8|compound|START_ENTITY -LSB-|nmod|CD8 -RSB-|advcl|-LSB- -RSB-|nsubj|levels levels|amod|END_ENTITY	-LSB- The relationship between CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T cells in the peripheral blood of patients with pancreatic_carcinoma and IL-4 , IFN-gamma levels -RSB- .
20117266	0	CD4	48,51	IFN-gamma	123,132	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY T|nsubj|characterization T|dobj|responses responses|dep|interplay interplay|nmod|cells cells|amod|END_ENTITY	Functional characterization of in vivo effector CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cell responses in acute Toxoplasmosis : an interplay of IFN-gamma and cytolytic T cells .
20156102	0	CD4	0,3	IFN-gamma	48,57	CD4	IFN-gamma	920	3458	Gene	Gene	CD25|compound|START_ENTITY T|nsubj|CD25 T|ccomp|inhibit inhibit|dep|utilizing utilizing|nsubj|production production|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells inhibit CD8 -LRB- + -RRB- IFN-gamma production during acute and chronic FIV_infection utilizing a membrane TGF-beta-dependent mechanism .
20364089	0	CD4	100,103	IFN-gamma	63,72	CD4	IFN-gamma	920	3458	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Control_of_vaccinia_virus skin_lesions by long-term-maintained IFN-gamma + TNF-alpha + effector/memory CD4 + lymphocytes in humans .
20544034	0	CD4	134,137	IFN-gamma	66,75	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	played|nmod|START_ENTITY played|nmod|production production|amod|END_ENTITY	Role of 4-1BB receptor in the control played by CD8 -LRB- + -RRB- T cells on IFN-gamma production by Mycobacterium_tuberculosis antigen-specific CD4 -LRB- + -RRB- T Cells .
20599915	0	CD4	145,148	IFN-gamma	132,141	CD4	IFN-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY induces|nmod|+ induces|dobj|production production|nmod|END_ENTITY	Ursolic_acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4 + na ve T cells .
2492048	0	CD4	60,63	IFN-gamma	27,36	CD4	IFN-gamma	920	3458	Gene	Gene	levels|compound|START_ENTITY decreases|dobj|levels decreases|nsubj|Treatment Treatment|nmod|END_ENTITY	Treatment with recombinant IFN-gamma decreases cell surface CD4 levels on peripheral blood monocytes and on myelomonocyte cell lines .
2573635	0	CD4	0,3	IFN-gamma	62,71	CD4	IFN-gamma	24932(Tax:10116)	25712(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY affect|nsubj|cells affect|dobj|production production|nmod|END_ENTITY	CD4 + suppressor cells differentially affect the production of IFN-gamma by effector cells of experimental_autoimmune_encephalomyelitis .
7530038	0	CD4	90,93	IFN-gamma	37,46	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	response|compound|START_ENTITY profile|nmod|response profile|amod|END_ENTITY	Rapid establishment of a stable IL-4 / IFN-gamma production profile in the antigen-specific CD4 + T cell response to protein immunization .
7594459	0	CD4	37,40	IFN-gamma	93,102	CD4	IFN-gamma	920	3458	Gene	Gene	T|compound|START_ENTITY priming|nmod|T Prostaglandin_E2|nmod|priming cells|amod|Prostaglandin_E2 inhibits|nsubj|cells inhibits|xcomp|produce produce|dobj|END_ENTITY	Prostaglandin_E2 at priming of naive CD4 + T cells inhibits acquisition of ability to produce IFN-gamma and IL-2 , but not IL-4 and IL-5 .
7722313	0	CD4	72,75	IFN-gamma	44,53	CD4	IFN-gamma	24932(Tax:10116)	25712(Tax:10116)	Gene	Gene	T|compound|START_ENTITY cells|nsubj|T antitumor|xcomp|cells antitumor|nsubj|elicits elicits|compound|END_ENTITY	Rat mammary adenocarcinoma 13762 expressing IFN-gamma elicits antitumor CD4 + MHC class II-restricted T cells that are cytolytic in vitro and tumoricidal in vivo .
7947460	0	CD4	81,84	IFN-gamma	26,35	CD4	IFN-gamma	920	3458	Gene	Gene	clones|compound|START_ENTITY transcription|nmod|clones transcription|amod|END_ENTITY	IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4 + allergen-specific Th2 T cell clones .
8097225	0	CD4	29,32	IFN-gamma	64,73	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	clones|compound|START_ENTITY activity|nmod|clones correlates|nsubj|activity correlates|nmod|production production|amod|END_ENTITY	Cytolytic activity of murine CD4 + T cell clones correlates with IFN-gamma production in mouse strains having a BALB/c background .
8370421	0	CD4	37,40	IFN-gamma	0,9	CD4	IFN-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY secretion|nmod|+ secretion|amod|END_ENTITY	IFN-gamma and TNF-alpha secretion by CD4 + and CD8 + TCR alpha beta + T-cell clones derived early after allogeneic bone marrow transplantation .
8553586	0	CD4	84,87	IFN-gamma	167,176	CD4	IFN-gamma	920	3458	Gene	Gene	results|compound|START_ENTITY infected|nmod|results infected|nmod|responses responses|nmod|production production|nmod|END_ENTITY	Transmission of HIV-1 from productively infected mature Langerhans cells to primary CD4 + T lymphocytes results in altered T cell responses with enhanced production of IFN-gamma and IL-10 .
8635694	0	CD4	57,60	IFN-gamma	90,99	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY protein|nmod|cells Expression|nmod|protein associated|nsubjpass|Expression associated|nmod|production production|amod|END_ENTITY	Expression and release of LAG-3-encoded protein by human CD4 + T cells are associated with IFN-gamma production .
8786299	0	CD4	63,66	IFN-gamma	80,89	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY priming|nmod|cells enhance|dobj|priming enhance|nmod|END_ENTITY	High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4 + T cells for IFN-gamma but have differential effects on priming for IL-4 .
8921430	0	CD4	109,112	IFN-gamma	79,88	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY synthesis|nmod|lymphocytes synthesis|amod|END_ENTITY	Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes .
9127013	0	CD4	85,88	IFN-gamma	118,127	CD4	IFN-gamma	713807(Tax:9544)	574282(Tax:9544)	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|secrete secrete|dobj|END_ENTITY	HIV-1 env DNA vaccine administered to rhesus_monkeys elicits MHC class II-restricted CD4 + T helper cells that secrete IFN-gamma and TNF-alpha .
9218571	0	CD4	77,80	IFN-gamma	35,44	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Melatonin enhances IL-2 , IL-6 , and IFN-gamma production by human circulating CD4 + cells : a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes .
9344500	0	CD4	40,43	IFN-gamma	105,114	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY provide|dobj|cells provide|nmod|signals signals|nmod|priming priming|nmod|production production|amod|END_ENTITY	Prostaglandin_E2 and IL-4 provide naive CD4 + T cells with distinct inhibitory signals for the priming of IFN-gamma production .
9510174	0	CD4	0,3	IFN-gamma	96,105	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|have have|dobj|production production|nmod|END_ENTITY	CD4 + , but not CD8 + , T cells from mammary_tumor-bearing mice have a down-regulated production of IFN-gamma : role of phosphatidyl_serine .
9590250	0	CD4	0,3	IFN-gamma	37,46	CD4	IFN-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	CD4 + and CD8 + T cell interactions in IFN-gamma and IL-4 responses to viral_infections : requirements for IL-2 .
9759858	0	CD4	140,143	IFN-gamma	117,126	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY IL-12-mediated|nmod|cells IL-12-mediated|dobj|secretion secretion|amod|END_ENTITY	IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4 + T cells in the absence of TCR ligation .
9809616	0	CD4	89,92	IFN-gamma	59,68	CD4	IFN-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|production production|amod|END_ENTITY	Bacterial extract OM85-BV induces interleukin-12-dependent IFN-gamma production by human CD4 + T cells .
9822276	0	CD4	124,127	IFN-gamma	18,27	CD4	IFN-gamma	920	3458	Gene	Gene	induction|nmod|START_ENTITY stages|nmod|induction necessary|nmod|stages necessary|nsubj|Interferon-gamma Interferon-gamma|appos|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium_leprae heat_shock protein -LRB- hsp -RRB- 65 kD .
20933471	0	CD4	20,23	IFN-y	50,55	CD4	IFN-y	920	3458	Gene	Gene	cells|compound|START_ENTITY Characterization|nmod|cells Characterization|acl|producing producing|dobj|END_ENTITY	Characterization of CD4 and CD8 T cells producing IFN-y in human latent and active tuberculosis .
21182084	0	CD4	40,43	IFN-y	69,74	CD4	IFN-y	920	3458	Gene	Gene	Generation|nmod|START_ENTITY +|nsubj|Generation +|nmod|END_ENTITY	Generation of human Th1-like regulatory CD4 + T cells by an intrinsic IFN-y - and T-bet-dependent pathway .
21520494	0	CD4	62,65	IFN-y	55,60	CD4	IFN-y	920	3458	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Carica_papaya increases regulatory T cells and reduces IFN-y + CD4 + T cells in healthy human subjects .
21572994	0	CD4	53,56	IFN-y	20,25	CD4	IFN-y	920	3458	Gene	Gene	T|compound|START_ENTITY ve|dobj|T human|xcomp|ve cells|amod|human production|nmod|cells production|amod|END_ENTITY	Antigen-independent IFN-y production by human na ve CD4 T cells activated by IL-12 plus IL-18 .
22205032	0	CD4	81,84	IFN-y	117,122	CD4	IFN-y	920	3458	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas_ligand-enhanced IFN-y and nitric_oxide .
22461525	0	CD4	80,83	IFN-y	38,43	CD4	IFN-y	920	3458	Gene	Gene	cells|amod|START_ENTITY induces|nmod|cells induces|dobj|IL-2 IL-2|compound|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
22550536	0	CD4	5,8	IFN-y	54,59	CD4	IFN-y	920	3458	Gene	Gene	lymphocytes|compound|START_ENTITY participate|nsubj|lymphocytes participate|nmod|response response|amod|END_ENTITY	Both CD4 and CD8 lymphocytes participate in the IFN-y response to filamentous hemagglutinin from Bordetella_pertussis in infants , children , and adults .
22870329	0	CD4	60,63	IFN-y	126,131	CD4	IFN-y	920	3458	Gene	Gene	cells|compound|START_ENTITY conversion|nmod|cells inhibits|dobj|conversion inhibits|nmod|cells cells|nmod|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22870329	0	CD4	78,81	IFN-y	126,131	CD4	IFN-y	920	3458	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
23233724	0	CD4	11,14	IFN-y	0,5	CD4	IFN-y	12504(Tax:10090)	3458	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	IFN-y from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium_tuberculosis_infection .
23255246	0	CD4	122,125	IFN-y	100,105	CD4	IFN-y	920	3458	Gene	Gene	T|compound|START_ENTITY memory|nmod|T memory|amod|END_ENTITY	Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-y memory in human CD4 -LRB- + -RRB- T lymphocytes .
23266494	0	CD4	78,81	IFN-y	58,63	CD4	IFN-y	920	3458	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|compound|END_ENTITY	Depletion of IL-22 during culture enhanced antigen-driven IFN-y production by CD4 -LRB- + -RRB- T cells from patients with active TB .
23684621	0	CD4	97,100	IFN-y	76,81	CD4	IFN-y	920	3458	Gene	Gene	lymphocytes|compound|START_ENTITY enhances|nmod|lymphocytes enhances|dobj|secretion secretion|amod|END_ENTITY	Antigen presentation by small intestinal epithelial cells uniquely enhances IFN-y secretion from CD4 + intestinal intraepithelial lymphocytes .
23772025	0	CD4	90,93	IFN-y	68,73	CD4	IFN-y	920	3458	Gene	Gene	cells|compound|START_ENTITY suppresses|nmod|cells suppresses|dobj|colitis colitis|nmod|inhibition inhibition|nmod|production production|amod|END_ENTITY	Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-y production from CD4 T cells .
24704866	0	CD4	103,106	IFN-y	69,74	CD4	IFN-y	920	3458	Gene	Gene	lymphocytes|compound|START_ENTITY secreted|nmod|lymphocytes END_ENTITY|acl|secreted	Downregulation of microRNA-24 and -181 parallels the upregulation of IFN-y secreted by activated human CD4 lymphocytes .
24710491	0	CD4	22,25	IFN-y	57,62	CD4	IFN-y	920	3458	Gene	Gene	Cells|nsubj|START_ENTITY Cells|dobj|Interferon-y Interferon-y|appos|END_ENTITY	Neuroantigen-Specific CD4 Cells Expressing Interferon-y -LRB- IFN-y -RRB- , Interleukin _ -LRB- IL -RRB- -2 and IL-3 in a Mutually Exclusive Manner Prevail in Experimental_Allergic_Encephalomyelitis -LRB- EAE -RRB- .
24817699	0	CD4	16,19	IFN-y	36,41	CD4	IFN-y	920	3458	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|END_ENTITY	CD70-expressing CD4 T cells produce IFN-y and IL-17 in rheumatoid_arthritis .
25196330	0	CD4	100,103	IFN-y	80,85	CD4	IFN-y	920	3458	Gene	Gene	T|compound|START_ENTITY enhances|nmod|T enhances|dobj|production production|amod|END_ENTITY	Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-y production by CD4 -LRB- + -RRB- T cells .
25209422	10	CD4	1647,1650	IFN-y	1639,1644	CD8	IFN-y	925	3458	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The median frequency of antigen specific IFN-y + CD4 T cells increased at week two ; however , only the increase in the ESAT-6 / CFP-10-specific response was significant -LRB- P = 0 .
26347149	0	CD4	29,32	IFN-y	52,57	CD4	IFN-y	920	3458	Gene	Gene	CD25|compound|START_ENTITY Feasibility|nmod|CD25 Tregs|nsubj|Feasibility Tregs|nmod|END_ENTITY	Feasibility of up-regulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Tregs by IFN-y in myasthenia_gravis patients .
26347149	0	CD4	29,32	IFN-y	52,57	CD4	IFN-y	920	3458	Gene	Gene	CD25|compound|START_ENTITY Feasibility|nmod|CD25 Tregs|nsubj|Feasibility Tregs|nmod|END_ENTITY	Feasibility of up-regulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Tregs by IFN-y in myasthenia_gravis patients .
26989699	0	CD4	57,60	IFN-y	39,44	CD4	IFN-y	920	3458	Gene	Gene	Induces|nmod|START_ENTITY Induces|dobj|Response Response|compound|END_ENTITY	Group_B_Streptococcus Induces a Robust IFN-y Response by CD4 -LRB- + -RRB- T Cells in an In Vitro and In Vivo Model .
25924431	0	CD4	40,43	IFNAR	20,25	CD4	IFNAR	920	3454	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 expression|compound|END_ENTITY	-LSB- Effects of altered IFNAR expression on CD4 + CD25 + treg cell dysfunction in patients with systemic_lupus_erythematosus -RSB- .
23255246	0	CD4	122,125	IFNG	27,31	CD4	IFNG	920	3458	Gene	Gene	T|compound|START_ENTITY memory|nmod|T functional|dep|memory lymphocytes|amod|functional development|nmod|lymphocytes associated|nmod|development associated|nsubjpass|Loss Loss|nmod|methylation methylation|nmod|promoter promoter|compound|END_ENTITY	Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-y memory in human CD4 -LRB- + -RRB- T lymphocytes .
24244422	0	CD4	26,29	IFNG	18,22	CD4	IFNG	920	3458	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Downregulation of IFNG in CD4 -LRB- + -RRB- T cells in lung_cancer through hypermethylation : a possible mechanism of tumor-induced immunosuppression .
11498249	0	CD4	33,36	IFN_gamma	0,9	CD4	IFN gamma	407098(Tax:9913)	281237(Tax:9913)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	IFN_gamma and IL-4 production by CD4 , CD8 and WC1 gamma delta TCR -LRB- + -RRB- T cells from cattle lymph nodes and blood .
21856936	0	CD4	89,92	IFN_regulatory_factor_4	21,44	CD4	IFN regulatory factor 4	920	3662	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Simvastatin inhibits IFN_regulatory_factor_4 expression and Th17 cell differentiation in CD4 + T cells derived from patients with multiple_sclerosis .
11321126	0	CD4	8,11	IFNgamma	93,101	CD4	IFNgamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|production production|compound|END_ENTITY	Soluble CD4 suppresses T-dependent IgG2a antibody response of CD4 loosing mice by inhibiting IFNgamma production .
26639194	0	CD4	25,28	IFNy	6,10	CD4	IFNy	920	3458	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	IL-10 / IFNy co-expressing CD4 -LRB- + -RRB- T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses .
15048719	0	CD4	103,106	IL-1	0,4	CD4	IL-1	920	3552	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhance|dobj|proliferation acts|xcomp|enhance acts|nsubj|END_ENTITY	IL-1 acts on antigen-presenting cells to enhance the in vivo proliferation of antigen-stimulated naive CD4 T cells via a CD28-dependent mechanism that does not involve increased expression of CD28 ligands .
1533149	0	CD4	39,42	IL-1	85,89	CD4	IL-1	12504(Tax:10090)	111343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY requirements|nmod|+ requirements|dep|role role|nmod|secretion secretion|compound|END_ENTITY	Similar co-stimulation requirements of CD4 + and CD8 + primary T helper cells : role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation .
18477692	0	CD4	66,69	IL-1	25,29	CD4	IL-1	12504(Tax:10090)	111343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion/differentiation|nmod|+ END_ENTITY|nmod|expansion/differentiation	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
19359475	0	CD4	22,25	IL-1	0,4	CD4	IL-1	920	3553	Gene	Gene	cells|compound|START_ENTITY acts|nmod|cells acts|nsubj|END_ENTITY	IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation .
20540113	0	CD4	94,97	IL-1	24,28	CD4	IL-1	12504(Tax:10090)	111343(Tax:10090)	Gene	Gene	T|compound|START_ENTITY trigger|nmod|T trigger|nsubj|interactions interactions|nmod|members members|compound|END_ENTITY	TGF-b interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4 -LRB- + -RRB- T cells .
21998454	0	CD4	49,52	IL-1	8,12	CD4	IL-1	920	3553	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Ex vivo IL-1 receptor type I expression in human CD4 + T cells identifies an early intermediate in the differentiation of Th17 from FOXP3 + naive regulatory T cells .
23181791	0	CD4	80,83	IL-1	26,30	CD4	IL-1	920	3552	Gene	Gene	lymphocytes|compound|START_ENTITY IL-17A|nmod|lymphocytes END_ENTITY|nmod|IL-17A	Human eosinophils release IL-1 and increase expression of IL-17A in activated CD4 + T lymphocytes .
9698257	0	CD4	49,52	IL-1-alpha	0,10	CD4	IL-1-alpha	12504(Tax:10090)	16175(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	IL-1-alpha and TNF-alpha differentially regulate CD4 and Mac-1 expression in mouse microglia .
10490963	0	CD4	13,16	IL-10	68,73	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	alloantigen-specific|compound|START_ENTITY Induction|nmod|alloantigen-specific hyporesponsiveness|nsubj|Induction hyporesponsiveness|nmod|END_ENTITY	Induction of CD4 + T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta .
11207250	0	CD4	56,59	IL-10	94,99	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells regulate|dobj|expansion regulate|nmod|production production|nmod|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11207250	0	CD4	6,9	IL-10	94,99	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|regulate regulate|nmod|production production|nmod|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11489988	0	CD4	30,33	IL-10	61,66	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|acl|increase increase|dobj|production production|compound|END_ENTITY	Testosterone acts directly on CD4 + T lymphocytes to increase IL-10 production .
11809742	0	CD4	8,11	IL-10	114,119	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|role role|nmod|END_ENTITY	Natural CD4 CD25 -LRB- + -RRB- regulatory T cells control the burst of superantigen-induced cytokine production : the role of IL-10 .
12209095	0	CD4	0,3	IL-10	41,46	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|acl|engineered engineered|xcomp|produce produce|dobj|END_ENTITY	CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway_hyperreactivity and inflammation .
12609834	0	CD4	39,42	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY induce|dobj|CD25 induce|nsubj|END_ENTITY	IL-10 and TGF-beta induce alloreactive CD4 + CD25 - T cells to acquire regulatory cell function .
12789226	0	CD4	19,22	IL-10	13,18	CD4	IL-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Induction of IL-10 + CD4 + CD25 + T cells by grass pollen immunotherapy .
12928371	0	CD4	41,44	IL-10	27,32	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY induces|dobj|populations induces|nsubj|overexpression overexpression|nmod|END_ENTITY	Systemic overexpression of IL-10 induces CD4 + CD25 + cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion .
12938218	0	CD4	26,29	IL-10	76,81	CD4	IL-10	920	3586	Gene	Gene	cells|nummod|START_ENTITY subpopulation|nmod|cells controls|nsubj|subpopulation controls|xcomp|wasting wasting|dobj|secretion secretion|dep|END_ENTITY	A unique subpopulation of CD4 + regulatory T cells controls wasting disease , IL-10 secretion and T cell homeostasis .
1356125	0	CD4	38,41	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	clones|compound|START_ENTITY subsets|nmod|clones produced|nmod|subsets produced|nsubjpass|END_ENTITY	IL-10 is produced by subsets of human CD4 + T cell clones and peripheral blood T cells .
1382908	0	CD4	56,59	IL-10	0,5	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY arising|nmod|mouse production|acl|arising production|compound|END_ENTITY	IL-10 production in a CD5 + B cell lymphoma arising in a CD4 monoclonal antibody-treated SJL mouse .
14519757	0	CD4	92,95	IL-10	52,57	CD4	IL-10	920	3586	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ END_ENTITY|nmod|generation	The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4 + CD25 + and CD8 + regulatory T cell subsets .
14607897	0	CD4	0,3	IL-10	62,67	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|dobj|role role|nmod|END_ENTITY	CD4 + CD25 + regulatory T cells cure murine colitis : the role of IL-10 , TGF-beta , and CTLA4 .
14734610	0	CD4	90,93	IL-10	0,5	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY involved|nmod|cells involved|nsubjpass|END_ENTITY	IL-10 is involved in the suppression of experimental_autoimmune_encephalomyelitis by CD25 + CD4 + regulatory T cells .
15184347	0	CD4	83,86	IL-10	134,139	CD4	IL-10	920	3586	Gene	Gene	proliferation|compound|START_ENTITY presence|nmod|proliferation generated|nmod|presence cells|acl|generated cells|dep|type type|amod|modulation modulation|nmod|END_ENTITY	Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4 + T-cell proliferation : modulation by autocrine IL-10 , enhanced T-cell apoptosis and T regulatory type 1 cells .
15187167	0	CD4	169,172	IL-10	135,140	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY neutralization|nmod|cells neutralization|nmod|production production|compound|END_ENTITY	Defective dendritic_cell_function_in_HIV-infected patients receiving effective highly active antiretroviral therapy : neutralization of IL-10 production and depletion of CD4 + CD25 + T cells restore high levels of HIV-specific CD4 + T cell responses induced by dendritic cells generated in the presence of IFN-alpha .
15187167	0	CD4	223,226	IL-10	135,140	CD4	IL-10	920	3586	Gene	Gene	responses|compound|START_ENTITY levels|nmod|responses restore|dobj|levels cells|dep|restore neutralization|nmod|cells neutralization|nmod|production production|compound|END_ENTITY	Defective dendritic_cell_function_in_HIV-infected patients receiving effective highly active antiretroviral therapy : neutralization of IL-10 production and depletion of CD4 + CD25 + T cells restore high levels of HIV-specific CD4 + T cell responses induced by dendritic cells generated in the presence of IFN-alpha .
15535835	0	CD4	118,121	IL-10	14,19	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY suppressor_of_cytokine_signaling_1|nmod|cells production|nmod|suppressor_of_cytokine_signaling_1 gamma|dobj|production gamma|nsubj|Resistance Resistance|nmod|inhibition inhibition|compound|END_ENTITY	Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor_of_cytokine_signaling_1 in CD4 + T cells from patients with rheumatoid_arthritis .
15556685	0	CD4	174,177	IL-10	94,99	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY activating|dobj|cells suppress|advcl|activating suppress|nsubj|cells cells|appos|END_ENTITY	Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 -LRB- IL-10 -RRB- suppress Th1-type responses while selectively activating IL-10-producing CD4 + T cells .
15688350	0	CD4	25,28	IL-10	86,91	CD4	IL-10	920	3586	Gene	Gene	co-localizes|nmod|START_ENTITY required|nsubjpass|co-localizes required|nmod|production production|compound|END_ENTITY	Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production .
15761493	0	CD4	115,118	IL-10	95,100	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY associated|nmod|cells associated|nmod|production production|compound|END_ENTITY	Impaired humoral immunity in X-linked_lymphoproliferative_disease is associated with defective IL-10 production by CD4 + T cells .
15899924	0	CD4	59,62	IL-10	37,42	CD4	IL-10	920	3586	Gene	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration .
16791879	0	CD4	117,120	IL-10	110,115	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania_donovani and the expansion of IL-10 + CD4 + T cells .
1680917	0	CD4	23,26	IL-10	14,19	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Production of IL-10 by CD4 + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth_infection .
16818744	0	CD4	157,160	IL-10	37,42	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induction|nmod|+ environment|nmod|induction influence|nmod|environment Suppression|dep|influence Suppression|nmod|immunity immunity|acl|infiltrating infiltrating|nsubj|cells cells|compound|END_ENTITY	Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor : influence of tumor environment on the induction of CD4 + and CD8 + regulatory T cells .
16889540	0	CD4	0,3	IL-10	62,67	CD4	IL-10	920	3586	Gene	Gene	+25|compound|START_ENTITY cells|nummod|+25 limit|nsubj|cells limit|xcomp|Th1-autoimmunity Th1-autoimmunity|advcl|inducing inducing|dobj|END_ENTITY	CD4 +25 + regulatory T cells limit Th1-autoimmunity by inducing IL-10 producing T cells following human lung transplantation .
17015751	0	CD4	62,65	IL-10	13,18	CD4	IL-10	920	3586	Gene	Gene	patients|nmod|START_ENTITY suppressors|nmod|patients suppressors|compound|END_ENTITY	Induction of IL-10 suppressors in lung transplant patients by CD4 +25 + regulatory T cells through CTLA-4 signaling .
17196245	0	CD4	141,144	IL-10	119,124	CD4	IL-10	920	3586	Gene	Gene	lymphocytes|nummod|START_ENTITY expression|nmod|lymphocytes expression|amod|END_ENTITY	CD25_deficiency causes an immune_dysregulation , polyendocrinopathy , enteropathy , X-linked-like_syndrome , and defective IL-10 expression from CD4 lymphocytes .
17237391	0	CD4	25,28	IL-10	97,102	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY occurring|dobj|CD25 T|csubj|occurring T|ccomp|depends depends|nmod|induction induction|compound|END_ENTITY	Naturally occurring lung CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta .
17389235	0	CD4	60,63	IL-10	24,29	CD4	IL-10	920	3586	Gene	Gene	+|compound|START_ENTITY distinct|nmod|+ cells|amod|distinct accumulation|dep|cells accumulation|nmod|mRNA mRNA|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17548634	0	CD4	49,52	IL-10	0,5	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY derived|dobj|cells intestinally|acl|derived movement|nmod|intestinally regulates|dobj|movement regulates|nsubj|END_ENTITY	IL-10 regulates movement of intestinally derived CD4 + T cells to the liver .
17675500	0	CD4	63,66	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	lymphocytes|compound|START_ENTITY memory|nmod|lymphocytes excluded|nmod|memory excluded|nsubjpass|END_ENTITY	IL-10 is excluded from the functional cytokine memory of human CD4 + memory T lymphocytes .
17675505	0	CD4	105,108	IL-10	147,152	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY reveal|dobj|cells reveal|nmod|source source|nmod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17675505	0	CD4	18,21	IL-10	147,152	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reveal|nmod|cells reveal|nmod|source source|nmod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17990114	0	CD4	0,3	IL-10	82,87	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|nmod|intestinal_inflammation intestinal_inflammation|nmod|mice mice|compound|END_ENTITY	CD4 + CD25 + regulatory T cells have divergent effects on intestinal_inflammation in IL-10 gene-deficient mice .
18549444	0	CD4	29,32	IL-10	13,18	CD4	IL-10	920	3586	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells END_ENTITY|acl|producing	Induction of IL-10 producing CD4 + T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells .
18549444	0	CD4	29,32	IL-10	89,94	CD4	IL-10	920	3586	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells producing|nmod|marrow marrow|compound|END_ENTITY	Induction of IL-10 producing CD4 + T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells .
18569073	0	CD4	130,133	IL-10	183,188	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	modulating|dobj|START_ENTITY modulating|advcl|producing producing|dobj|END_ENTITY	Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10 .
18634243	0	CD4	88,91	IL-10	18,23	CD4	IL-10	920	3586	Gene	Gene	+|compound|START_ENTITY supernatants|nmod|+ cytokines|nmod|supernatants cytokines|nsubj|Concentration Concentration|nmod|END_ENTITY	-LSB- Concentration of IL-10 , IL-13 and IFN-gamma cytokines in supernatants of microcultured CD4 + and NK cells in patients with non-allergic bronchial_asthma -RSB- .
19250511	0	CD4	69,72	IL-10	39,44	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY dependent|nmod|cells dependent|nsubj|Reduction Reduction|nmod|Helicobacter_infection Helicobacter_infection|nmod|mice mice|amod|END_ENTITY	Reduction of Helicobacter_infection in IL-10 - / - mice is dependent on CD4 + T cells but not on mast cells .
19535638	0	CD4	49,52	IL-10	33,38	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|generation generation|nmod|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19682278	0	CD4	20,23	IL-10	13,18	CD4	IL-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Induction of IL-10 + CD4 + CD25 + regulatory T cells with decreased NF-kB expression during immunotherapy .
19748991	0	CD4	37,40	IL-10	16,21	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY regulates|nmod|cells regulates|xcomp|END_ENTITY	IL-27 regulates IL-10 and IL-17 from CD4 + cells in nonhealing Leishmania_major_infection .
19849943	0	CD4	12,15	IL-10	42,47	CD4	IL-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY Changes|nmod|CD25 +|nsubj|Changes +|dobj|cells cells|appos|levels levels|amod|END_ENTITY	-LSB- Changes of CD4 + CD25 + regulatory T cells , IL-10 and TGF-beta1 levels in peripheral blood in children with asthma -RSB- .
20133700	0	CD4	26,29	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|dep|END_ENTITY	IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral_infection .
20177412	0	CD4	28,31	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	required|nmod|START_ENTITY required|dep|END_ENTITY	IL-10 is required for human CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cell-mediated suppression of xenogeneic proliferation .
20544263	0	CD4	108,111	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	cells|nummod|START_ENTITY insulin|nmod|cells reduce|nmod|insulin END_ENTITY|appos|reduce	IL-10 / TGF-beta-treated dendritic cells , pulsed with insulin , specifically reduce the response to insulin of CD4 + effector/memory T cells from type 1 diabetic individuals .
20723599	0	CD4	38,41	IL-10	0,5	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY necessary|nmod|cells necessary|nsubj|END_ENTITY	IL-10 within the CNS is necessary for CD4 + T cells to mediate neuroprotection .
20809522	0	CD4	52,55	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	T-cell|compound|START_ENTITY regulates|dobj|T-cell regulates|nsubj|END_ENTITY	IL-10 produced by activated human B cells regulates CD4 -LRB- + -RRB- T-cell activation in vitro .
20812238	0	CD4	53,56	IL-10	76,81	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|compound|START_ENTITY production|nmod|T modulate|iobj|production modulate|dobj|cells cells|nmod|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20812238	0	CD4	6,9	IL-10	76,81	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|modulate modulate|dobj|cells cells|nmod|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20977501	0	CD4	53,56	IL-10	33,38	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|production production|compound|END_ENTITY	Neonatal BCG vaccination induces IL-10 production by CD4 + CD25 + T cells .
21227406	0	CD4	105,108	IL-10	83,88	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human na ve CD4 + T cells .
21297642	0	CD4	0,3	IL-10	67,72	CD4	IL-10	920	3586	Gene	Gene	help|compound|START_ENTITY induce|nsubj|help induce|dobj|production production|amod|END_ENTITY	CD4 + T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs .
21440248	0	CD4	40,43	IL-10	15,20	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	IRF4 regulates IL-10 gene expression in CD4 -LRB- + -RRB- T cells through differential nuclear translocation .
21533081	0	CD4	51,54	IL-10	28,33	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	TLR2-dependent induction of IL-10 and Foxp3 + CD25 + CD4 + regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo .
21558138	0	CD4	21,24	IL-10	79,84	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY contribute|nsubj|cells contribute|nmod|overproduction overproduction|nmod|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
21844390	0	CD4	9,12	IL-10	54,59	CD4	IL-10	920	3586	Gene	Gene	subsets|compound|START_ENTITY produce|nsubj|subsets produce|xcomp|END_ENTITY	Multiple CD4 + T cell subsets produce immunomodulatory IL-10 during respiratory_syncytial_virus_infection .
21874651	0	CD4	29,32	IL-10	9,14	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	Enhanced IL-10 production by CD4 + T cells primed in IL-15Ra-deficient mice .
22192790	0	CD4	19,22	IL-10	0,5	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	IL-10 signaling in CD4 + T cells is critical for the pathogenesis of collagen-induced arthritis .
22586040	0	CD4	60,63	IL-10	80,85	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY microRNAs|nmod|cells family|nmod|microRNAs regulation|nmod|family alters|nsubj|regulation alters|dobj|expression expression|compound|END_ENTITY	Differential regulation of the Let-7 family of microRNAs in CD4 + T cells alters IL-10 expression .
22692497	0	CD4	97,100	IL-10	9,14	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY phenotype|nmod|T cell|acl:relcl|phenotype confers|dobj|cell confers|nsubj|expression expression|compound|END_ENTITY	Enforced IL-10 expression confers type 1 regulatory T cell -LRB- Tr1 -RRB- phenotype and function to human CD4 -LRB- + -RRB- T cells .
22754764	0	CD4	112,115	IL-10	82,87	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY induced|nmod|T induced|dobj|secretion secretion|compound|END_ENTITY	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
22842304	0	CD4	114,117	IL-10	94,99	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induce|nmod|cells induce|dobj|production production|compound|END_ENTITY	Schistosoma_mansoni schistosomula tegument -LRB- Smteg -RRB- immunization in absence of adjuvant induce IL-10 production by CD4 + cells and failed to protect mice against challenge_infection .
22903229	0	CD4	99,102	IL-10	92,97	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The role of 1a,25-dihydroxyvitamin _ D3 and cytokines in the promotion of distinct Foxp3 + and IL-10 + CD4 + T cells .
23292714	0	CD4	146,149	IL-10	118,123	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|compound|START_ENTITY tolerance|dep|T tolerance|acl|induced induced|nmod|transfer transfer|nmod|cells cells|nmod|numbers numbers|nmod|IFN-y IFN-y|compound|END_ENTITY	Immune tolerance induced by intravenous transfer of immature dendritic cells via up-regulating numbers of suppressive IL-10 -LRB- + -RRB- IFN-y -LRB- + -RRB- - producing CD4 -LRB- + -RRB- T cells .
23349024	0	CD4	97,100	IL-10	60,65	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4 + T cells .
23545299	0	CD4	74,77	IL-10	67,72	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
23997221	0	CD4	109,112	IL-10	135,140	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY shut|dobj|cells shut|nmod|receptor receptor|compound|END_ENTITY	Mycobacteria-infected dendritic cells attract neutrophils that produce IL-10 and specifically shut down Th17 CD4 T cells through their IL-10 receptor .
24130479	0	CD4	92,95	IL-10	76,81	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY producing|dobj|cells elicit|xcomp|producing elicit|dobj|END_ENTITY	Human_cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4 T cells .
24452947	0	CD4	33,36	IL-10	146,151	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells contributes|nsubj|induction contributes|nmod|regulation regulation|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24568737	0	CD4	76,79	IL-10	99,104	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY T|acl:relcl|T T|nsubj|cells cells|nmod|END_ENTITY	Inhibition of TNF receptor signaling by anti-TNFa biologicals primes na ve CD4 -LRB- + -RRB- T cells towards IL-10 -LRB- + -RRB- T cells with a regulatory phenotype and function .
24598451	0	CD4	68,71	IL-10	98,103	CD4	IL-10	920	3586	Gene	Gene	responses|compound|START_ENTITY suppress|dobj|responses suppress|nmod|secretion secretion|compound|END_ENTITY	Ovarian_tumor ascites CD14 + cells suppress dendritic cell-activated CD4 + T-cell responses through IL-10 secretion and indoleamine 2,3-dioxygenase .
24613988	0	CD4	141,144	IL-10	121,126	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|expression expression|compound|END_ENTITY	Direct infection of dendritic cells during chronic viral_infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells .
24699268	0	CD4	31,34	IL-10	64,69	CD4	IL-10	920	3586	Gene	Gene	+|compound|START_ENTITY Expansion|nmod|+ Expansion|acl|expressing expressing|dobj|members members|amod|superfamily superfamily|amod|END_ENTITY	Expansion of parasite-specific CD4 + and CD8 + T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic_filariasis .
24703254	0	CD4	0,3	IL-10	25,30	CD4	IL-10	403931(Tax:9615)	403628(Tax:9615)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|xcomp|END_ENTITY	CD4 + FOXP3 + cells produce IL-10 in the spleens of dogs with visceral_leishmaniasis .
25499021	0	CD4	205,208	IL-10	179,184	CD4	IL-10	920	3586	Gene	Gene	ratio|nmod|START_ENTITY reduce|dobj|ratio reduce|iobj|FoxP3 FoxP3|compound|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
25550089	0	CD4	83,86	IL-10	26,31	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY compromised|nmod|T Tregs|acl|compromised END_ENTITY|nmod|Tregs	Insufficient secretion of IL-10 by Tregs compromised its control on over-activated CD4 -LRB- + -RRB- T effector cells in newly diagnosed adult immune_thrombocytopenia patients .
25589067	0	CD4	80,83	IL-10	71,76	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	Induced|nmod|START_ENTITY Induced|nmod|END_ENTITY	A Novel Regulatory Macrophage Induced by a Helminth Molecule Instructs IL-10 in CD4 + T Cells and Protects against Mucosal_Inflammation .
25627813	0	CD4	56,59	IL-10	126,131	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY effector|nsubj|expression effector|nmod|modification modification|nmod|promoter promoter|compound|END_ENTITY	Glycogen synthase kinase-3 controls IL-10 expression in CD4 -LRB- + -RRB- effector T-cell subsets through epigenetic modification of the IL-10 promoter .
25627813	0	CD4	56,59	IL-10	36,41	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Glycogen synthase kinase-3 controls IL-10 expression in CD4 -LRB- + -RRB- effector T-cell subsets through epigenetic modification of the IL-10 promoter .
25974019	0	CD4	88,91	IL-10	56,61	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Skin|nmod|Cells Suppressive|nmod|Skin Suppressive|nsubj|Production Production|compound|END_ENTITY	Helminth_Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4 + T Cells That Are Functionally Suppressive .
26140236	0	CD4	77,80	IL-10	0,5	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	inhibiting|dobj|START_ENTITY enhances|advcl|inhibiting enhances|nsubj|END_ENTITY	IL-10 enhances CTL-mediated tumor rejection by inhibiting highly suppressive CD4 -LRB- + -RRB- T cells and promoting CTL persistence in a murine model of plasmacytoma .
26147684	0	CD4	23,26	IL-10	14,19	CD4	IL-10	920	3586	Gene	Gene	cells|amod|START_ENTITY Production|dep|cells Production|nmod|END_ENTITY	Production of IL-10 by CD4 -LRB- + -RRB- regulatory T cells during the resolution of infection promotes the maturation of memory CD8 -LRB- + -RRB- T cells .
26459508	0	CD4	18,21	IL-10	28,33	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Parasite-specific CD4 + IFN-y + IL-10 + T cells distribute within both lymphoid and non-lymphoid compartments and are controlled systemically by IL-27 and ICOS during blood-stage malaria_infection .
26639194	0	CD4	25,28	IL-10	0,5	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY IFNy|nmod|T IFNy|compound|END_ENTITY	IL-10 / IFNy co-expressing CD4 -LRB- + -RRB- T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses .
26639194	0	CD4	25,28	IL-10	51,56	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY T|dep|cells cells|acl|induced induced|nmod|DC DC|compound|END_ENTITY	IL-10 / IFNy co-expressing CD4 -LRB- + -RRB- T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses .
26709703	0	CD4	40,43	IL-10	62,67	CD4	IL-10	920	3586	Gene	Gene	Secreting|compound|START_ENTITY Secreting|amod|END_ENTITY	Modulation of Cytokine Secretion Allows CD4 T Cells Secreting IL-10 and IL-17 to Simultaneously Participate in Maintaining Tolerance and Immunity .
26829554	0	CD4	33,36	IL-10	13,18	CD4	IL-10	920	3586	Gene	Gene	Correlates|compound|START_ENTITY Induction|nmod|Correlates Induction|nmod|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
26928119	0	CD4	104,107	IL-10	79,84	CD4	IL-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY production|acl:relcl|CD25 production|compound|END_ENTITY	NAD -LRB- + -RRB- regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells independent .
27028319	0	CD4	13,16	IL-10	72,77	CD4	IL-10	920	3586	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Pathway Pathway|nmod|Production Production|nmod|Recognition Recognition|compound|END_ENTITY	HIV-infected CD4 + T Cells Use T-bet-dependent Pathway for Production of IL-10 Upon Antigen Recognition .
27067196	0	CD4	61,64	IL-10	127,132	CD4	IL-10	920	3586	Gene	Gene	quality|compound|START_ENTITY quality|nmod|END_ENTITY	Effective antimalarial chemoprevention in childhood enhances CD4 + T cell quality and limits CD4 production of immunoregulatory IL-10 .
7684412	0	CD4	44,47	IL-10	18,23	CD4	IL-10	920	3586	Gene	Gene	subsets|nmod|START_ENTITY END_ENTITY|nmod|subsets	Direct effects of IL-10 on subsets of human CD4 + T cell clones and resting T cells .
8752931	0	CD4	130,133	IL-10	29,34	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|compound|START_ENTITY dependent|nmod|T response|amod|dependent succumb|nmod|response cells|amod|succumb infected|nmod|cells infected|nmod|absence absence|nmod|END_ENTITY	In the absence of endogenous IL-10 , mice acutely infected with Toxoplasma_gondii succumb to a lethal immune response dependent on CD4 + T cells and accompanied by overproduction of IL-12 , IFN-gamma and TNF-alpha .
8840221	0	CD4	107,110	IL-10	16,21	CD4	IL-10	920	3586	Gene	Gene	T|compound|START_ENTITY secretion|dep|T secretion|appos|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- secretion in systemic_lupus_erythematosus and rheumatoid_arthritis : IL-10-dependent CD4 + CD45RO + T cell-B cell antibody synthesis .
8918588	0	CD4	27,30	IL-10	8,13	CD4	IL-10	920	3586	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Reduced IL-10 secretion by CD4 + T lymphocytes expressing mutant cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- .
9352427	0	CD4	62,65	IL-10	74,79	CD4	IL-10	920	3586	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Increased in vitro induced CD4 + and CD8 + T cell IFN-gamma and CD4 + T cell IL-10 production in stable relapsing multiple_sclerosis .
9472657	0	CD4	126,129	IL-10	17,22	CD4	IL-10	920	3586	Gene	Gene	cells|nummod|START_ENTITY associated|nmod|cells associated|nsubjpass|dysregulation dysregulation|compound|END_ENTITY	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9472657	0	CD4	40,43	IL-10	17,22	CD4	IL-10	920	3586	Gene	Gene	cells|nummod|START_ENTITY dysregulation|nmod|cells dysregulation|compound|END_ENTITY	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9531324	0	CD4	59,62	IL-10	145,150	CD4	IL-10	920	3586	Gene	Gene	cells|compound|START_ENTITY cells|dep|exhibiting exhibiting|dobj|pattern pattern|dep|reversal reversal|nmod|END_ENTITY	Active Wegener 's _ granulomatosis is associated with HLA-DR + CD4 + T cells exhibiting an unbalanced Th1-type T cell cytokine pattern : reversal with IL-10 .
9759837	0	CD4	53,56	IL-10	23,28	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	Urocanic acid enhances IL-10 production in activated CD4 + T cells .
9780221	0	CD4	94,97	IL-10	0,5	CD4	IL-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T|compound|START_ENTITY requirement|nmod|T pathway|nmod|requirement diabetes|nmod|pathway impacts|dobj|diabetes impacts|nsubj|END_ENTITY	IL-10 impacts autoimmune diabetes via a CD8 + T cell pathway circumventing the requirement for CD4 + T and B lymphocytes .
11809914	0	CD4	48,51	IL-13	17,22	CD4	IL-13	920	3596	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|compound|END_ENTITY	Dysregulation of IL-13 production by cord blood CD4 + T cells is associated with the subsequent development of atopic_disease in infants .
8980464	0	CD4	17,20	IL-13	8,13	CD4	IL-13	920	3596	Gene	Gene	production|compound|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of IL-13 in CD4 T cell-dependent IgE production in atopy .
11550091	0	CD4	21,24	IL-15	114,119	CD4	IL-15	920	3600	Gene	Gene	memory|compound|START_ENTITY subset|nmod|memory T|nsubj|subset T|ccomp|prone prone|nmod|apoptosis apoptosis|acl:relcl|prevented prevented|nmod|interleukin-15 interleukin-15|appos|END_ENTITY	The CD7 -LRB- - -RRB- subset of CD4 -LRB- + -RRB- memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 -LRB- IL-15 -RRB- .
14662842	0	CD4	96,99	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	cells|compound|START_ENTITY expand|dobj|cells expand|nsubj|antigen antigen|amod|END_ENTITY	IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4 + T cells that require antigen-specific activation for suppression .
15308379	0	CD4	82,85	IL-15	0,5	CD4	IL-15	713807(Tax:9544)	699616(Tax:9544)	Gene	Gene	generation|nmod|START_ENTITY IL-2|nmod|generation superior|nmod|IL-2 superior|nsubj|END_ENTITY	IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus_macaques .
15972637	0	CD4	139,142	IL-15	33,38	CD4	IL-15	920	3600	Gene	Gene	help|compound|START_ENTITY independent|nmod|help cells|ccomp|independent function|nmod|cells plasmid|nmod|function plasmid|nsubj|Coimmunization Coimmunization|nmod|END_ENTITY	Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help .
16614074	0	CD4	51,54	IL-15	8,13	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	response|compound|START_ENTITY priming|nmod|response Lack|nmod|priming Lack|nmod|results results|compound|END_ENTITY	Lack of IL-15 results in the suboptimal priming of CD4 + T cell response against an intracellular parasite .
16691294	0	CD4	14,17	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-15 induces CD4 effector memory_T cell production and tissue emigration in nonhuman primates .
17420265	0	CD4	10,13	IL-15	34,39	CD4	IL-15	920	3600	Gene	Gene	cells|compound|START_ENTITY dependent|nsubj|cells dependent|advmod|END_ENTITY	Antiviral CD4 + memory T cells are IL-15 dependent .
17823984	0	CD4	62,65	IL-15	0,5	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	response|compound|START_ENTITY exacerbates|nmod|response exacerbates|nsubj|END_ENTITY	IL-15 exacerbates collagen-induced_arthritis with an enhanced CD4 + T cell response to produce IL-17 .
18362335	0	CD4	23,26	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	+|compound|START_ENTITY mediator|nmod|+ END_ENTITY|nmod|mediator	IL-15 as a mediator of CD4 + help for CD8 + T cell longevity and avoidance of TRAIL-mediated apoptosis .
18493981	0	CD4	34,37	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	cells|amod|START_ENTITY inducer|nmod|cells expressing|nsubj|inducer acts|advcl|expressing acts|nsubj|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
19155491	0	CD4	78,81	IL-15	10,15	CD4	IL-15	920	3600	Gene	Gene	cells|compound|START_ENTITY susceptibility|nmod|cells associated|nmod|susceptibility associated|nsubjpass|production production|compound|END_ENTITY	Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian_immunodeficiency_virus during acute_infection .
20007590	0	CD4	102,105	IL-15	58,63	CD4	IL-15	920	3600	Gene	Gene	+|compound|START_ENTITY equilibrium|nmod|+ expression|nmod|equilibrium expression|compound|END_ENTITY	A dual action of rheumatoid_arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4 + CD25 + regulatory T cells and CD4 + CD25 - responder T cells .
21474552	0	CD4	24,27	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	deficiency|compound|START_ENTITY overcomes|dobj|deficiency overcomes|nsubj|vivo vivo|compound|END_ENTITY	IL-15 ex vivo overcomes CD4 + T cell deficiency for the induction of human antigen-specific CD8 + T cell responses .
21635686	0	CD4	113,116	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	cells|compound|START_ENTITY enhances|advcl|cells enhances|nsubj|END_ENTITY	IL-15 preferentially enhances functional properties and antigen-specific responses of CD4 + CD28 -LRB- null -RRB- compared to CD4 + CD28 + T cells .
21673554	0	CD4	38,41	IL-15	116,121	CD4	IL-15	920	3600	Gene	Gene	cells|compound|START_ENTITY proliferate|nsubj|cells proliferate|nmod|response response|nmod|END_ENTITY	Despite an impaired response to IL-7 , CD4 + EM T cells from HIV-positive patients proliferate normally in response to IL-15 and its superagonist , RLI .
21723324	0	CD4	50,53	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	CD25|compound|START_ENTITY proliferation|nmod|CD25 induce|dobj|proliferation induce|nsubj|cells cells|amod|END_ENTITY	IL-15 and dendritic cells induce proliferation of CD4 + CD25 + regulatory T cells from peripheral blood .
21822803	0	CD4	71,74	IL-15	109,114	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	expansion|nmod|START_ENTITY T|nsubj|expansion T|nmod|expression expression|compound|END_ENTITY	Selective expansion and enhanced anti-tumor effect of antigen-specific CD4 -LRB- + -RRB- T cells by retrovirus-mediated IL-15 expression .
22993203	0	CD4	75,78	IL-15	12,17	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	T|compound|START_ENTITY activating|nmod|T END_ENTITY|acl|activating	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
22993612	0	CD4	54,57	IL-15	18,23	CD4	IL-15	920	3600	Gene	Gene	Concentrations|nmod|START_ENTITY Concentrations|nmod|END_ENTITY	Concentrations of IL-15 , IL-18 , IFN-y and activity of CD4 -LRB- + -RRB- , CD8 -LRB- + -RRB- and NK cells at admission in children with viral_bronchiolitis .
23028916	0	CD4	110,113	IL-15	0,5	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	T|compound|START_ENTITY function|nmod|T inhibiting|dobj|function vitro|advcl|inhibiting cells|amod|vitro expansion|nmod|cells augments|dobj|expansion augments|nsubj|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23028916	0	CD4	27,30	IL-15	0,5	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY augments|dobj|expansion augments|nsubj|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
24500400	0	CD4	41,44	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells binding|nsubj|expression prolongs|xcomp|binding prolongs|nsubj|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24658435	0	CD4	50,53	IL-15	0,5	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	T|compound|START_ENTITY homeostasis|nmod|T lymphocytes|nsubj|homeostasis regulates|ccomp|lymphocytes regulates|nsubj|trans-presentation trans-presentation|compound|END_ENTITY	IL-15 trans-presentation regulates homeostasis of CD4 -LRB- + -RRB- T lymphocytes .
24706798	0	CD4	81,84	IL-15	0,5	CD4	IL-15	12504(Tax:10090)	16168(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY requires|dobj|cells requires|nsubj|vaccine vaccine|amod|adjuvanted adjuvanted|amod|END_ENTITY	IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4 + T cells for heterosubtypic protection .
24790790	0	CD4	10,13	IL-15	71,76	CD4	IL-15	920	3600	Gene	Gene	T|nsubj|START_ENTITY T|nmod|response response|compound|END_ENTITY	Sustained CD4 -LRB- + -RRB- T cell-driven lymphopenia without a compensatory IL-7 / IL-15 response among high-grade glioma patients treated with radiation and temozolomide .
25617471	0	CD4	45,48	IL-15	0,5	CD4	IL-15	920	3600	Gene	Gene	CD28|compound|START_ENTITY Properties|nmod|CD28 Amplifies|dep|Properties Amplifies|compound|END_ENTITY	IL-15 Amplifies the Pathogenic Properties of CD4 + CD28 - T Cells in Multiple_Sclerosis .
26034206	0	CD4	0,3	IL-15	85,90	CD4	IL-15	920	3600	Gene	Gene	lymphocytes|compound|START_ENTITY resemble|nsubj|lymphocytes resemble|ccomp|lymphocytes lymphocytes|nmod|END_ENTITY	CD4 + CD28null T lymphocytes resemble CD8 + CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients .
9725205	0	CD4	76,79	IL-15	52,57	CD4	IL-15	920	3600	Gene	Gene	responsiveness|compound|START_ENTITY enhance|dobj|responsiveness enhance|nsubj|activities activities|nmod|END_ENTITY	Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4 + T cell responsiveness to antigen .
10779741	0	CD4	14,17	IL-16	65,70	CD4	IL-16	12504(Tax:10090)	16170(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	Cutting edge : CD4 is not required for the functional activity of IL-16 .
12191564	0	CD4	21,24	IL-16	104,109	CD4	IL-16	920	3603	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|dep|T T|dep|reference reference|nmod|END_ENTITY	Relationship between CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T cell ratio and T cell activation in multiple_myeloma : reference to IL-16 .
14607889	0	CD4	20,23	IL-16	14,19	CD4	IL-16	12504(Tax:10090)	16170(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|appos|induces	Cutting edge : IL-16 / CD4 preferentially induces Th1 cell migration : requirement of CCR5 .
16455991	0	CD4	50,53	IL-16	44,49	CD4	IL-16	920	3603	Gene	Gene	signaling|compound|START_ENTITY dependent|nsubj|signaling CXCR3|parataxis|dependent CXCR3|acl|desensitization desensitization|nmod|END_ENTITY	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
16729885	0	CD4	36,39	IL-16	14,19	CD4	IL-16	920	3603	Gene	Gene	inflammation|compound|START_ENTITY correlates|nmod|inflammation correlates|nsubj|Production Production|nmod|END_ENTITY	Production of IL-16 correlates with CD4 + Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple_sclerosis_lesions .
17624801	0	CD4	62,65	IL-16	0,5	CD4	IL-16	920	3603	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|signaling signaling|compound|END_ENTITY	IL-16 signaling specifically induces STAT6 activation through CD4 .
8757315	0	CD4	0,3	IL-16	11,16	CD4	IL-16	920	3603	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|inhibits inhibits|nsubj|END_ENTITY	CD4 ligand IL-16 inhibits the mixed lymphocyte reaction .
9176493	0	CD4	6,9	IL-16	34,39	CD4	IL-16	920	3603	Gene	Gene	cells|compound|START_ENTITY cells|acl|transfected transfected|nmod|cDNA cDNA|compound|END_ENTITY	Human CD4 + cells transfected with IL-16 cDNA are resistant to HIV-1_infection : inhibition of mRNA expression .
9300714	0	CD4	29,32	IL-16	71,76	CD4	IL-16	920	3603	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Human mast cells produce the CD4 + T lymphocyte chemoattractant factor , IL-16 .
9498748	0	CD4	26,29	IL-16	42,47	CD4	IL-16	920	3603	Gene	Gene	+|compound|START_ENTITY activation|nmod|+ T|nsubj|activation T|nmod|END_ENTITY	Synergistic activation of CD4 + T cells by IL-16 and IL-2 .
9637499	0	CD4	46,49	IL-16	0,5	CD4	IL-16	920	3603	Gene	Gene	macrophages|compound|START_ENTITY signaling|nmod|macrophages SAPK|acl|signaling activates|dobj|SAPK activates|nsubj|END_ENTITY	IL-16 activates the SAPK signaling pathway in CD4 + macrophages .
9802374	0	CD4	25,28	IL-16	65,70	CD4	IL-16	920	3603	Gene	Gene	Association|nmod|START_ENTITY +|nsubj|Association +|nmod|expression expression|compound|END_ENTITY	Association of increased CD4 + T-cell infiltration with increased IL-16 gene expression in atopic_dermatitis .
9973381	0	CD4	37,40	IL-16	26,31	CD4	IL-16	920	3603	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Processing and release of IL-16 from CD4 + but not CD8 + T cells is activation dependent .
16148138	0	CD4	7,10	IL-17	129,134	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	immunopathology|compound|START_ENTITY dependent|nsubj|immunopathology dependent|nmod|levels levels|nmod|END_ENTITY	Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17 .
17335887	0	CD4	15,18	IL-17	39,44	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY promotes|dobj|cells promotes|xcomp|produce produce|dobj|END_ENTITY	IL-23 promotes CD4 + T cells to produce IL-17 in Vogt-Koyanagi-Harada_disease .
17823984	0	CD4	62,65	IL-17	94,99	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	response|compound|START_ENTITY exacerbates|nmod|response exacerbates|advcl|produce produce|dobj|END_ENTITY	IL-15 exacerbates collagen-induced_arthritis with an enhanced CD4 + T cell response to produce IL-17 .
18209095	0	CD4	46,49	IL-17	19,24	CD4	IL-17	920	3605	Gene	Gene	+|nummod|START_ENTITY END_ENTITY|dep|+	Distinct , specific IL-17 - and IL-22-producing CD4 + T cell subsets contribute to the human anti-mycobacterial immune response .
18941193	0	CD4	156,159	IL-17	149,154	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
19017937	0	CD4	82,85	IL-17	62,67	CD4	IL-17	920	3605	Gene	Gene	cells|nummod|START_ENTITY amplifies|nmod|cells amplifies|dobj|production production|compound|END_ENTITY	Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4 + T cells in experimental_autoimmune_encephalomyelitis and in multiple_sclerosis .
19433458	0	CD4	54,57	IL-17	112,117	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY control|nsubj|cells control|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	Suppression of murine SLE by oral anti-CD3 : inducible CD4 + CD25-LAP + regulatory T cells control the expansion of IL-17 + follicular helper T cells .
19449310	0	CD4	111,114	IL-17	64,69	CD4	IL-17	920	3605	Gene	Gene	T|compound|START_ENTITY development|nmod|T END_ENTITY|nmod|development	The role of retinoic_acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4 + T cells .
19533748	0	CD4	45,48	IL-17	38,43	CD4	IL-17	920	3605	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Pretreatment frequency of circulating IL-17 + CD4 + T-cells , but not Tregs , correlates with clinical response to whole-cell vaccination in prostate_cancer patients .
19616200	0	CD4	11,14	IL-17	102,107	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|Foxp3 Foxp3|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19996179	0	CD4	55,58	IL-17	76,81	CD4	IL-17	920	3605	Gene	Gene	cells|nummod|START_ENTITY lacking|nsubj|cells lacking|dobj|production production|compound|END_ENTITY	Human Langerhans cells induce distinct IL-22-producing CD4 + T cells lacking IL-17 production .
20015694	0	CD4	65,68	IL-17	39,44	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY influences|nmod|cells influences|nmod|expression expression|compound|END_ENTITY	Suppressive influences of IFN-alpha on IL-17 expression in human CD4 + T cells .
20080304	0	CD4	63,66	IL-17	14,19	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY pathway|nmod|cells Regulation|nmod|pathway Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus .
20554330	0	CD4	7,10	IL-17	75,80	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|xcomp|END_ENTITY	Memory CD4 + CD127high T cells from patients with multiple_sclerosis produce IL-17 in response to myelin antigens .
20571894	0	CD4	95,98	IL-17	78,83	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY expressing|dobj|cells END_ENTITY|acl|expressing	IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4 + T -LRB- T -LRB- H -RRB- 17 -RRB- cells in the periphery .
20921287	0	CD4	18,21	IL-17	79,84	CD4	IL-17	920	3605	Gene	Gene	T|compound|START_ENTITY subset|nmod|T produce|nsubj|subset produce|dobj|cytokine cytokine|compound|END_ENTITY	A novel subset of CD4 -LRB- + -RRB- T -LRB- H -RRB- 2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic_asthma .
21369705	0	CD4	19,22	IL-17	43,48	CD4	IL-17	920	3605	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|produce produce|dobj|END_ENTITY	Tumor-infiltrating CD4 + Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric_cancer .
21692201	0	CD4	0,3	IL-17	59,64	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|levels levels|nmod|END_ENTITY	CD4 T cells from behcet patients produce high levels of IL-17 .
21862617	0	CD4	52,55	IL-17	106,111	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY depletion|nmod|CD25 autoimmune_thyroiditis|nmod|depletion Induction|nmod|autoimmune_thyroiditis +|nsubj|Induction +|dobj|cells cells|nmod|END_ENTITY	Induction of autoimmune_thyroiditis by depletion of CD4 + CD25 + regulatory T cells in thyroiditis-resistant IL-17 , but not interferon-gamma receptor , knockout nonobese diabetic-H2h4 mice .
22005586	0	CD4	70,73	IL-17	38,43	CD4	IL-17	407098(Tax:9913)	282863(Tax:9913)	Gene	Gene	T-cells|compound|START_ENTITY secretion|nmod|T-cells secretion|compound|END_ENTITY	Parasite limiting macrophages promote IL-17 secretion in naive bovine CD4 T-cells during Neospora caninum infection .
22170065	0	CD4	117,120	IL-17	100,105	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	+|compound|START_ENTITY producing|dobj|+ regulates|parataxis|producing regulates|nmod|differentiation differentiation|nmod|interleukin-17 interleukin-17|appos|END_ENTITY	Transforming growth factor-b protein inversely regulates in vivo differentiation of interleukin-17 -LRB- IL-17 -RRB- - producing CD4 + and CD8 + T cells .
22219644	0	CD4	34,37	IL-17	71,76	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells Upregulation|nmod|expression promotes|nsubj|Upregulation promotes|dobj|secretion secretion|nmod|END_ENTITY	Upregulation of DR3 expression in CD4 T cells promotes secretion of IL-17 in experimental autoimmune uveitis .
22461525	0	CD4	80,83	IL-17	55,60	CD4	IL-17	920	3605	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
22464815	0	CD4	85,88	IL-17	65,70	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY inducing|nmod|cells inducing|dobj|production production|compound|END_ENTITY	Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4 + CD45RO + T cells .
23226194	0	CD4	64,67	IL-17	82,87	CD4	IL-22	920	50616	Gene	Gene	cells|nummod|START_ENTITY polarize|dobj|cells polarize|nmod|cells cells|amod|END_ENTITY	Differential capacity of human skin dendritic cells to polarize CD4 + T cells into IL-17 , IL-21 and IL-22 producing cells .
23776439	0	CD4	19,22	IL-17	111,116	CD4	IL-17	920	3605	Gene	Gene	FoxP3|amod|START_ENTITY levels|nmod|FoxP3 T|nsubj|levels T|ccomp|contribute contribute|nmod|secretion secretion|nmod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
24097227	0	CD4	75,78	IL-17	42,47	CD4	IL-17	920	3605	Gene	Gene	cells|compound|START_ENTITY expressing|dobj|cells Foxp3|acl|expressing secreting|dobj|Foxp3 circulating|advcl|secreting circulating|dobj|END_ENTITY	Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4 + T cells and defective suppressive function of circulating Foxp3 + regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory_bowel_disease patients .
24379058	0	CD4	113,116	IL-17	84,89	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	population|compound|START_ENTITY producing|nmod|population END_ENTITY|acl|producing	Blockade of IL-6 signal exacerbates acute_inflammatory_bowel_disease via inhibiting IL-17 producing in activated CD4 + Th17 population .
25142300	0	CD4	123,126	IL-17	103,108	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY modulating|nmod|cells modulating|dobj|production production|compound|END_ENTITY	IL-15-dependent CD8 + CD122 + T cells ameliorate experimental_autoimmune_encephalomyelitis by modulating IL-17 production by CD4 + T cells .
25241192	0	CD4	0,3	IL-17	41,46	CD4	IL-17	920	3605	Gene	Gene	chimera|nummod|START_ENTITY inhibits|nsubj|chimera inhibits|dobj|cells cells|amod|END_ENTITY	CD4 aptamer-RORyt shRNA chimera inhibits IL-17 synthesis by human CD4 -LRB- + -RRB- T cells .
25241192	0	CD4	66,69	IL-17	41,46	CD4	IL-17	920	3605	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	CD4 aptamer-RORyt shRNA chimera inhibits IL-17 synthesis by human CD4 -LRB- + -RRB- T cells .
25385822	0	CD4	41,44	IL-17	21,26	CD4	IL-17	920	3605	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Chloroquine Promotes IL-17 Production by CD4 + T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells .
25499021	0	CD4	205,208	IL-17	162,167	CD4	IL-17	920	3605	Gene	Gene	ratio|nmod|START_ENTITY reduce|dobj|ratio reduce|iobj|FoxP3 FoxP3|amod|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
26771189	0	CD4	44,47	IL-17	35,40	CD4	IL-17	920	3605	Gene	Gene	T-Cells|compound|START_ENTITY Expression|nmod|T-Cells Expression|nmod|END_ENTITY	Upregulated Cellular Expression of IL-17 by CD4 + T-Cells in Osteoporotic Postmenopausal Women .
26832697	0	CD4	47,50	IL-17	53,58	CD4	IL-17	24932(Tax:10116)	301289(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Changes of CD4 -LRB- + -RRB- Foxp3 + regulatory T cells and CD4 -LRB- + -RRB- IL-17 + T cells in acrolein exposure rats -RSB- .
26901413	0	CD4	105,108	IL-17	0,5	CD4	IL-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY CD3|nmod|Cells Interaction|nmod|CD3 Stimulation|nmod|Interaction Stimulation|nsubj|Induction Induction|compound|END_ENTITY	IL-17 Induction by ArtinM is Due to Stimulation of IL-23_and_IL-1 Release and/or Interaction with CD3 in CD4 + T Cells .
20109749	0	CD4	61,64	IL-17A	94,100	CD4	IL-17A	920	3605	Gene	Gene	subset|nmod|START_ENTITY Identification|nmod|subset T|nsubj|Identification T|dobj|cells cells|acl:relcl|produce produce|dobj|END_ENTITY	Identification of a novel subset of human circulating memory CD4 -LRB- + -RRB- T cells that produce both IL-17A and IL-4 .
21959269	0	CD4	16,19	IL-17A	59,65	CD4	IL-17A	920	3605	Gene	Gene	T|nsubj|START_ENTITY T|dobj|cells cells|nmod|END_ENTITY	MCAM-expressing CD4 -LRB- + -RRB- T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune_diseases .
22993203	0	CD4	75,78	IL-17A	54,60	CD4	IL-17A	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	T|compound|START_ENTITY activating|nmod|T activating|dobj|production production|compound|END_ENTITY	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
23181791	0	CD4	80,83	IL-17A	60,66	CD4	IL-17A	920	3605	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	Human eosinophils release IL-1 and increase expression of IL-17A in activated CD4 + T lymphocytes .
23957337	0	CD4	27,30	IL-17A	10,16	CD4	IL-17A	920	3605	Gene	Gene	cells|nummod|START_ENTITY secreting|dobj|cells END_ENTITY|acl|secreting	Increased IL-17A secreting CD4 + T cells , serum IL-17 levels and exhaled nitric_oxide are correlated with childhood_asthma severity .
24043897	0	CD4	61,64	IL-17A	32,38	CD4	IL-17A	920	3605	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|dobj|production production|compound|END_ENTITY	Cholera toxin directly enhances IL-17A production from human CD4 + T cells .
25790134	0	CD4	46,49	IL-17A	25,31	CD4	IL-17A	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Production|nmod|Foxp3 Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
26375594	0	CD4	94,97	IL-17A	67,73	CD4	IL-17A	407098(Tax:9913)	282863(Tax:9913)	Gene	Gene	Lymphocytes|compound|START_ENTITY Depends|nmod|Lymphocytes Depends|nmod|Production Production|nmod|END_ENTITY	Antigen-Specific Mammary Inflammation Depends on the Production of IL-17A and IFN-y by Bovine CD4 + T Lymphocytes .
11035116	0	CD4	17,20	IL-18	8,13	CD4	IL-18	920	3606	Gene	Gene	activation|compound|START_ENTITY Role|nmod|activation Role|nmod|END_ENTITY	Role of IL-18 in CD4 + T lymphocyte activation in sarcoidosis .
10337025	0	CD4	24,27	IL-2	51,55	CD4	IL-2	920	3558	Gene	Gene	T_lymphocytopenia|compound|START_ENTITY Treatment|nmod|T_lymphocytopenia Treatment|nmod|END_ENTITY	Treatment of idiopathic CD4 T_lymphocytopenia with IL-2 .
10553070	0	CD4	14,17	IL-2	103,107	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY contain|nsubj|cells contain|dobj|complexes complexes|dep|role role|nmod|activation activation|nmod|promoter promoter|compound|END_ENTITY	Primary human CD4 + T cells contain heterogeneous I kappa B kinase complexes : role in activation of the IL-2 promoter .
10570308	0	CD4	44,47	IL-2	87,91	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY cells|acl|secreting secreting|dobj|amounts amounts|nmod|END_ENTITY	Prostaglandin_E2 selectively inhibits human CD4 + T cells secreting low amounts of both IL-2 and IL-4 .
10647875	0	CD4	126,129	IL-2	50,54	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY percentage|nmod|cells associated|nmod|percentage associated|nsubjpass|ability ability|acl|augment augment|dobj|synthesis synthesis|nmod|END_ENTITY	Thalidomide 's ability to augment the synthesis of IL-2 in vitro in HIV-infected patients is associated with the percentage of CD4 + cells in their blood .
10679063	0	CD4	75,78	IL-2	21,25	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	IFN-alpha 2b reduces IL-2 production and IL-2_receptor function in primary CD4 + T cells .
10692234	0	CD4	63,66	IL-2	9,13	CD4	IL-2	920	3558	Gene	Gene	naive|dep|START_ENTITY cells|amod|naive reduces|dobj|cells reduces|nsubj|END_ENTITY	Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART .
10725703	0	CD4	54,57	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells regulate|dobj|expression regulate|nsubj|END_ENTITY	IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells .
10759770	0	CD4	82,85	IL-2	74,78	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Effects of therapy with highly active anti-retroviral therapy -LRB- HAART -RRB- and IL-2 on CD4 + and CD8 + lymphocyte apoptosis in HIV + patients .
10841521	0	CD4	51,54	IL-2	35,39	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY depends|nmod|T-cell depends|nsubj|immunotherapy immunotherapy|nmod|END_ENTITY	Melanoma immunotherapy by targeted IL-2 depends on CD4 -LRB- + -RRB- T-cell help mediated by CD40/CD40L interaction .
11318602	0	CD4	11,14	IL-2	121,125	CD4	IL-2	920	3558	Gene	Gene	lymphocytopenia|compound|START_ENTITY lymphocytopenia|acl|evolving evolving|xcomp|monoclonal monoclonal|xcomp|responsive responsive|nmod|therapy therapy|compound|END_ENTITY	Idiopathic CD4 + T cell lymphocytopenia evolving to monoclonal immunoglobulins and progressive renal_damage responsive to IL-2 therapy .
11363996	0	CD4	35,38	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	increases|compound|START_ENTITY finds|dobj|increases END_ENTITY|appos|finds	IL-2 : controlled trial finds major CD4 increases .
11364361	0	CD4	22,25	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY boost|dobj|cells boost|nsubj|injections injections|compound|END_ENTITY	IL-2 injections boost CD4 cells .
11366777	0	CD4	63,66	IL-2	13,17	CD4	IL-2	920	3558	Gene	Gene	counts|compound|START_ENTITY fantastic_increases|nmod|counts years|dep|fantastic_increases years|nmod|END_ENTITY	Two years of IL-2 in early HIV_disease -- fantastic_increases in CD4 + cell counts .
11579237	0	CD4	0,3	IL-2	92,96	CD4	IL-2	920	3558	Gene	Gene	expansions|compound|START_ENTITY associated|nsubjpass|expansions associated|nmod|cycles cycles|compound|END_ENTITY	CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV_infected patients .
11685114	0	CD4	91,94	IL-2	51,55	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY region|nmod|T region|compound|END_ENTITY	Alterations in transcription factor binding at the IL-2 promoter region in anergized human CD4 + T lymphocytes .
11740186	0	CD4	53,56	IL-2	24,28	CD4	IL-2	713807(Tax:9544)	708017(Tax:9544)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus_macaques .
12149467	0	CD4	40,43	IL-2	67,71	CD4	IL-2	920	3558	Gene	Gene	expansion|nmod|START_ENTITY +|nsubj|expansion +|nmod|treatment treatment|compound|END_ENTITY	Increased peripheral expansion of naive CD4 + T cells in vivo after IL-2 treatment of patients with HIV_infection .
12444145	0	CD4	62,65	IL-2	56,60	CD4	IL-2	920	3558	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
12534941	0	CD4	16,19	IL-2	64,68	CD4	IL-2	24932(Tax:10116)	116562(Tax:10116)	Gene	Gene	responsive|dep|START_ENTITY IL-4|amod|responsive +|nsubj|IL-4 +|parataxis|confers confers|nsubj|END_ENTITY	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
12660531	0	CD4	44,47	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY therapy|nmod|cells therapy|compound|END_ENTITY	IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia .
12660531	0	CD4	93,96	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	lymphopenia|compound|START_ENTITY therapy|nmod|lymphopenia therapy|compound|END_ENTITY	IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia .
12811838	0	CD4	28,31	IL-2	68,72	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY polarization|nmod|cells polarization|dep|cells cells|amod|activation activation|nmod|renders renders|compound|END_ENTITY	`` Bystander polarization '' of CD4 + T cells : activation with high-dose IL-2 renders naive T cells responsive to IL-12 and/or IL-18 in the absence of TCR ligation .
12816995	0	CD4	176,179	IL-2	143,147	CD4	IL-2	920	3558	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|compound|END_ENTITY	CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase , Bcl-xL , and IL-2 expression in primary human CD4 T lymphocytes .
12847246	0	CD4	87,90	IL-2	20,24	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY _|nmod|cells _|nsubj|roles roles|nmod|END_ENTITY	Regulatory roles of IL-2 and IL-4 in H4/inducible _ costimulator expression on activated CD4 + T cells during Th cell development .
12884288	0	CD4	80,83	IL-2	43,47	CD4	IL-2	920	3558	Gene	Gene	clones|compound|START_ENTITY END_ENTITY|nmod|clones	Analysis of allelic expression patterns of IL-2 , IL-3 , IL-4 , and IL-13 in human CD4 + T cell clones .
1346619	0	CD4	23,26	IL-2	46,50	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY precursor|nmod|cells precursor|acl|producing producing|dobj|END_ENTITY	A common precursor for CD4 + T cells producing IL-2 or IL-4 .
1357032	0	CD4	71,74	IL-2	15,19	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY transduction|nmod|cells alter|dobj|transduction alter|nsubj|levels levels|nmod|END_ENTITY	High levels of IL-2 alter signal transduction in cloned IL-4-producing CD4 T cells .
14512540	0	CD4	66,69	IL-2	124,128	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells associated|nsubjpass|proliferation associated|nmod|interleukin-2 interleukin-2|appos|END_ENTITY	Diminished proliferation of human_immunodeficiency_virus-specific CD4 + T cells is associated with diminished interleukin-2 -LRB- IL-2 -RRB- production and is recovered by exogenous IL-2 .
14734731	0	CD4	0,3	IL-2	56,60	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY generated|nsubj|+ generated|nmod|END_ENTITY	CD4 + and CD8 + regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a_lupus-like_syndrome .
15100259	0	CD4	20,23	IL-2	105,109	CD4	IL-2	920	3558	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|educate educate|dobj|CD25 CD25|dep|cells cells|dep|role role|nmod|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15100259	0	CD4	44,47	IL-2	105,109	CD4	IL-2	920	3558	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|dep|role role|nmod|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15128800	0	CD4	18,21	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	IL-2 secretion by CD4 + T cells in vivo is rapid , transient , and influenced by TCR-specific competition .
15153463	0	CD4	73,76	IL-2	14,18	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	function|compound|START_ENTITY activation|nmod|function required|nmod|activation required|nsubjpass|END_ENTITY	Cutting edge : IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function .
15214040	0	CD4	0,3	IL-2	119,123	CD4	IL-2	920	3558	Gene	Gene	IL-2Ralpha|amod|START_ENTITY IL-2Ralpha|acl:relcl|subset subset|acl:relcl|secrete secrete|nmod|END_ENTITY	CD4 -LRB- - -RRB- c-kit -LRB- - -RRB- CD3epsilon -LRB- - -RRB- IL-2Ralpha -LRB- + -RRB- Peyer 's patch cells are a novel cell subset which secrete IL-5 in response to IL-2 : implications for their role in IgA production .
15249725	0	CD4	35,38	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	IL-2 and IL-10 production by human CD4 + T cells is differentially regulated by p38 : mode of stimulation-dependent regulation of IL-2 .
15249725	0	CD4	35,38	IL-2	127,131	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells regulated|nsubjpass|production regulated|nmod|p38 p38|dep|mode mode|nmod|regulation regulation|nmod|END_ENTITY	IL-2 and IL-10 production by human CD4 + T cells is differentially regulated by p38 : mode of stimulation-dependent regulation of IL-2 .
15308379	0	CD4	82,85	IL-2	21,25	CD4	IL-2	713807(Tax:9544)	708017(Tax:9544)	Gene	Gene	generation|nmod|START_ENTITY END_ENTITY|nmod|generation	IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus_macaques .
1531763	0	CD4	39,42	IL-2	82,86	CD4	IL-2	920	3558	Gene	Gene	CD8|nummod|START_ENTITY CD8|dep|precursors precursors|nmod|pathway pathway|compound|END_ENTITY	IL-7 induces proliferation of CD3 - / low CD4 - CD8 - human thymocyte precursors by an IL-2 independent pathway .
1533149	0	CD4	39,42	IL-2	111,115	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY requirements|nmod|+ requirements|dep|role role|nmod|secretion secretion|compound|END_ENTITY	Similar co-stimulation requirements of CD4 + and CD8 + primary T helper cells : role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation .
15359109	0	CD4	63,66	IL-2	21,25	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	T|compound|START_ENTITY homeostasis|nmod|T administration|nmod|homeostasis administration|compound|END_ENTITY	Effects of exogenous IL-2 administration on the homeostasis of CD4 + T lymphocytes .
15470042	0	CD4	7,10	IL-2	116,120	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY fail|nsubj|cells fail|xcomp|undergo undergo|nmod|region region|nmod|gene gene|compound|END_ENTITY	Murine CD4 + CD25 + regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene .
15611237	0	CD4	66,69	IL-2	14,18	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY progression|nmod|cells signaling|nmod|progression Uncoupling|acl|signaling Uncoupling|nmod|END_ENTITY	Uncoupling of IL-2 signaling from cell cycle progression in naive CD4 + T cells by regulatory CD4 + CD25 + T lymphocytes .
15611237	0	CD4	93,96	IL-2	14,18	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY signaling|nmod|T Uncoupling|acl|signaling Uncoupling|nmod|END_ENTITY	Uncoupling of IL-2 signaling from cell cycle progression in naive CD4 + T cells by regulatory CD4 + CD25 + T lymphocytes .
15678692	0	CD4	75,78	IL-2	17,21	CD4	IL-2	920	3558	Gene	Gene	subset|compound|START_ENTITY proliferation|nmod|subset alters|dobj|proliferation Dysregulation|parataxis|alters Dysregulation|nmod|END_ENTITY	Dysregulation of IL-2 / IL-2R system alters proliferation of early activated CD4 + T cell subset in patients with end-stage_renal_failure .
15682445	0	CD4	33,36	IL-2	93,97	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	homeostasis|nummod|START_ENTITY regulates|dobj|homeostasis regulates|nmod|END_ENTITY	CD40/CD40L interaction regulates CD4 + CD25 + T reg homeostasis through dendritic cell-produced IL-2 .
15684039	0	CD4	38,41	IL-2	55,59	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY compete|nmod|cells compete|nmod|END_ENTITY	CD25 + CD4 + T cells compete with naive CD4 + T cells for IL-2 and exploit it for the induction of IL-10 production .
15684039	0	CD4	6,9	IL-2	55,59	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|compete compete|nmod|END_ENTITY	CD25 + CD4 + T cells compete with naive CD4 + T cells for IL-2 and exploit it for the induction of IL-10 production .
15753206	0	CD4	52,55	IL-2	139,143	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	maintenance|nmod|START_ENTITY regulatory|nsubj|maintenance regulatory|nmod|neutralization neutralization|compound|END_ENTITY	Homeostatic maintenance of natural Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells by interleukin _ -LRB- IL -RRB- -2 and induction of autoimmune_disease by IL-2 neutralization .
15770696	0	CD4	79,82	IL-2	57,61	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY help|nmod|cells cells|dep|help cells|amod|END_ENTITY	Activated CD1d-restricted natural killer T cells secrete IL-2 : innate help for CD4 + CD25 + regulatory T cells ?
15814700	0	CD4	123,126	IL-2	89,93	CD4	IL-2	713807(Tax:9544)	3558	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Dysfunction of simian_immunodeficiency_virus / simian_human_immunodeficiency_virus-induced IL-2 expression by central memory CD4 + T lymphocytes .
15944195	0	CD4	104,107	IL-2	40,44	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY modulate|nmod|cells modulate|dobj|production production|compound|END_ENTITY	DC-SIGN , but not sDC-SIGN , can modulate IL-2 production from PMA - and anti-CD3-stimulated primary human CD4 T cells .
16025158	0	CD4	35,38	IL-2	70,74	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY survival|nmod|T Induction|nmod|survival lymphocytes|nsubj|Induction lymphocytes|nmod|therapy therapy|compound|END_ENTITY	Induction of prolonged survival of CD4 + T lymphocytes by intermittent IL-2 therapy in HIV-infected patients .
16037071	0	CD4	23,26	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	lymphocytes|compound|START_ENTITY responsiveness|nmod|lymphocytes responsiveness|compound|END_ENTITY	IL-2 responsiveness of CD4 and CD8 lymphocytes : further investigations with human IL-2Rbeta transgenic_mice .
16304057	0	CD4	30,33	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	Foxp3|compound|START_ENTITY increases|dobj|Foxp3 increases|nsubj|administration administration|compound|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
16456009	0	CD4	17,20	IL-2	100,104	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY ligation|nmod|cells enhances|nsubj|ligation enhances|nmod|inhibition inhibition|compound|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16624934	0	CD4	72,75	IL-2	142,146	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY interactions|nmod|cells depends|nsubj|interactions depends|dobj|role role|nmod|END_ENTITY	Modulation of cell cycle progression by CTLA4-CD80 / CD86 interactions on CD4 + T cells depends on strength of the CD3 signal : critical role for IL-2 .
16637008	0	CD4	14,17	IL-2	45,49	CD4	IL-2	920	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY require|nsubj|cells require|dobj|END_ENTITY	LACK-reactive CD4 + T cells require autocrine IL-2 to mediate susceptibility to Leishmania_major .
16645171	0	CD4	41,44	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
1674955	0	CD4	103,106	IL-2	14,18	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY chain|nmod|cells synthesis|nmod|chain synthesis|compound|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
1677670	0	CD4	43,46	IL-2	24,28	CD4	IL-2	920	3558	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|production production|compound|END_ENTITY	Induction of high level IL-2 production in CD4 +8 - T helper lymphocytes requires post-thymic development .
16818762	0	CD4	92,95	IL-2	29,33	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY influenced|nmod|cells influenced|nsubjpass|remodeling remodeling|nmod|END_ENTITY	Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells .
16887978	0	CD4	106,109	IL-2	69,73	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY limits|nmod|cells limits|dobj|production production|compound|END_ENTITY	Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4 + CD25 + regulatory T cells .
16917540	0	CD4	50,53	IL-2	14,18	CD4	IL-2	920	3558	Gene	Gene	Tregs|compound|START_ENTITY expansion|nmod|Tregs expansion|compound|END_ENTITY	PTEN inhibits IL-2 receptor-mediated expansion of CD4 + CD25 + Tregs .
16982857	0	CD4	95,98	IL-2	44,48	CD4	IL-2	920	3558	Gene	Gene	response|compound|START_ENTITY sustained|nmod|response sustained|nsubjpass|signaling signaling|compound|END_ENTITY	Cutting edge : Paracrine , but not autocrine , IL-2 signaling is sustained during early antiviral CD4 T cell response .
16987710	0	CD4	24,27	IL-2	40,44	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY +|dep|expression expression|compound|END_ENTITY	Normalized CD8 + but not CD4 + lymphocyte IL-2 expression is associated with early treatment with highly active antiretroviral therapy .
17015695	0	CD4	84,87	IL-2	26,30	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	T|compound|START_ENTITY production|nmod|T controlling|dobj|production determinant|acl|controlling determinant|nsubj|availability availability|nmod|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
1703048	0	CD4	17,20	IL-2	241,245	CD4	IL-2	24932(Tax:10116)	116562(Tax:10116)	Gene	Gene	cell|compound|START_ENTITY Functions|nmod|cell subsets|nsubj|Functions subsets|dep|defined defined|dep|CD45RB CD45RB|parataxis|have have|advcl|producers producers|nmod|IFN IFN|nmod|presence presence|nmod|END_ENTITY	Functions of rat CD4 + T cell subsets defined by CD45RB : CD45RB - cells have a much stronger response to recall antigens , whereas polyclonally activated cells of both subsets are equally efficient producers of IFN in the presence of exogenous IL-2 .
17277105	0	CD4	48,51	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY convert|dobj|CD25 essential|xcomp|convert essential|nsubj|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17411376	0	CD4	113,116	IL-2	88,92	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY CD8|dep|+ CD8|compound|END_ENTITY	HLA-DR-restricted peptides identified in the Nef protein can induce HIV_type_1-specific IL-2 / IFN-gamma-secreting CD4 + and CD4 + / CD8 + T cells in humans after lipopeptide vaccination .
17545278	0	CD4	25,28	IL-2	64,68	CD4	IL-2	920	3558	Gene	Gene	function|compound|START_ENTITY maintenance|nmod|function maintenance|dep|potency potency|compound|END_ENTITY	The maintenance of human CD4 + CD25 + regulatory T cell function : IL-2 , IL-4 , IL-7 and IL-15 preserve optimal suppressive potency in vitro .
17548609	0	CD4	0,3	IL-2	190,194	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY produce|nsubj|cells produce|nmod|promoter promoter|compound|END_ENTITY	CD4 + T cells from simian_immunodeficiency_virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species : involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation .
17548609	0	CD4	0,3	IL-2	207,211	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY produce|nsubj|cells produce|nmod|promoter promoter|nmod|up-regulation up-regulation|compound|END_ENTITY	CD4 + T cells from simian_immunodeficiency_virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species : involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation .
17548609	0	CD4	0,3	IL-2	95,99	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY produce|nsubj|cells produce|xcomp|END_ENTITY	CD4 + T cells from simian_immunodeficiency_virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species : involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation .
17617586	0	CD4	28,31	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	populations|compound|START_ENTITY expansion|nmod|populations regulates|dobj|expansion regulates|nsubj|END_ENTITY	IL-2 regulates expansion of CD4 + T cell populations by affecting cell death : insights from modeling CFSE data .
18273057	0	CD4	40,43	IL-2	8,12	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY secreted|nmod|cells secreted|nsubj|Role Role|nmod|END_ENTITY	Role of IL-2 secreted by PADRE-specific CD4 + T cells in enhancing E7-specific CD8 + T-cell immune responses .
18395858	0	CD4	86,89	IL-2	17,21	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY role|nmod|Treg role|nmod|END_ENTITY	Critical role of IL-2 and TGF-beta in generation , function and stabilization of Foxp3 + CD4 + Treg .
18471351	0	CD4	68,71	IL-2	40,44	CD4	IL-2	24932(Tax:10116)	116562(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY mRNA|nmod|CD25 mRNA|compound|END_ENTITY	-LSB- Implication of different expression of IL-2 mRNA and IL-10 mRNA in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cell induced immune tolerance of liver transplantation in rat -RSB- .
18490709	0	CD4	20,23	IL-2	60,64	CD4	IL-2	920	3558	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|resistant resistant|nsubj|cells cells|acl|induced induced|nmod|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18493984	0	CD4	36,39	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY suppression|nmod|CD25 induces|nmod|suppression induces|dep|END_ENTITY	IL-2 induces in vivo suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18714004	0	CD4	29,32	IL-2	53,57	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY suppression|nmod|T lymphocytes|nmod|suppression lymphocytes|nsubj|responses responses|nmod|T T|amod|END_ENTITY	In vivo suppression of naive CD4 T cell responses by IL-2 - and antigen-stimulated T lymphocytes in the absence of APC competition .
18714042	0	CD4	22,25	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T memory|acl:relcl|lymphocytes memory|compound|END_ENTITY	IL-2 producing memory CD4 + T lymphocytes are closely associated with the generation of IgG-secreting plasma cells .
18827184	0	CD4	0,3	IL-2	43,47	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ alloactivated|nsubj|cells alloactivated|nmod|END_ENTITY	CD4 + CD25 + T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes , suggesting separate pathways of activation by Th1 and Th2 responses .
18941219	0	CD4	46,49	IL-2	21,25	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY variants|nmod|cell variants|compound|END_ENTITY	Impact of protective IL-2 allelic variants on CD4 + Foxp3 + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice .
19050236	0	CD4	96,99	IL-2	72,76	CD4	IL-2	920	3558	Gene	Gene	memory|compound|START_ENTITY regulating|nmod|memory regulating|dobj|secretion secretion|compound|END_ENTITY	Cutting edge : a T-bet-independent role for IFN-alpha/beta in regulating IL-2 secretion in human CD4 + central memory T cells .
19098490	0	CD4	64,67	IL-2	15,19	CD4	IL-2	920	3558	Gene	Gene	counts|compound|START_ENTITY maintaining|dobj|counts trial|dep|maintaining versus|nmod|trial versus|nsubj|Inferiority Inferiority|nmod|END_ENTITY	Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption : a randomized controlled trial .
19098490	0	CD4	64,67	IL-2	33,37	CD4	IL-2	920	3558	Gene	Gene	counts|compound|START_ENTITY maintaining|dobj|counts trial|dep|maintaining versus|nmod|trial versus|dobj|END_ENTITY	Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption : a randomized controlled trial .
19522766	0	CD4	41,44	IL-2	101,105	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY occurring|dobj|cells shedding|advcl|occurring CD25|acl|shedding inhibit|nsubj|CD25 inhibit|dobj|action action|nmod|END_ENTITY	CD25 shedding by human natural occurring CD4 + CD25 + regulatory T cells does not inhibit the action of IL-2 .
19553521	0	CD4	35,38	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates CD103 expression on CD4 + T cells in Scurfy mice that display both CD103-dependent and independent inflammation .
19654878	0	CD4	13,16	IL-2	85,89	CD4	IL-2	920	3558	Gene	Gene	CD25|compound|START_ENTITY Apoptosis|nmod|CD25 T|nsubj|Apoptosis T|ccomp|mediated mediated|nmod|deprivation deprivation|compound|END_ENTITY	Apoptosis of CD4 + CD25 -LRB- high -RRB- T cells in type 1 diabetes may be partially mediated by IL-2 deprivation .
1968430	0	CD4	65,68	IL-2	33,37	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY IL-4|nmod|populations IL-4|compound|END_ENTITY	Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4 + populations .
1972141	0	CD4	80,83	IL-2	8,12	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	helper|compound|START_ENTITY growth|nmod|helper Role|nmod|growth Role|nmod|END_ENTITY	Role of IL-2 , IL-4 and IL-6 in the growth and differentiation of tumor-specific CD4 + T helper and CD8 + T cytotoxic cells .
19878686	0	CD4	51,54	IL-2	21,25	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY helper|nummod|+ interplay|nmod|helper Modeling|nmod|interplay Modeling|dobj|role role|nmod|END_ENTITY	Modeling the role of IL-2 in the interplay between CD4 + helper and regulatory T cells : assessing general dynamical properties .
19950184	0	CD4	66,69	IL-2	20,24	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY expansion|nmod|T END_ENTITY|nmod|expansion	IL-7 is superior to IL-2 for ex vivo expansion of tumour-specific CD4 -LRB- + -RRB- T cells .
20081380	0	CD4	59,62	IL-2	24,28	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells END_ENTITY|nmod|expansion	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20137305	0	CD4	77,80	IL-2	35,39	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 induces|dobj|expansion induces|dep|END_ENTITY	-LSB- Combination of dexamethasone with IL-2 selectively induces the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft versus host disease . -RSB- .
20561440	0	CD4	22,25	IL-2	56,60	CD4	IL-2	920	3558	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|amod|END_ENTITY	-LSB- Relationship between CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , IL-2 , TGF-beta and acute_graft-versus_host_disease after allogeneic hematopoietic stem cell transplantation -RSB- .
20571894	0	CD4	95,98	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY expressing|dobj|cells IL-17|acl|expressing numbers|nmod|IL-17 maintains|nsubj|numbers maintains|dep|END_ENTITY	IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4 + T -LRB- T -LRB- H -RRB- 17 -RRB- cells in the periphery .
20574434	0	CD4	47,50	IL-2	77,81	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY D3|nmod|cells regulation|nmod|D3 enabled|nsubjpass|regulation enabled|nmod|END_ENTITY	Gene regulation by 1,25-dihydroxyvitamin _ D3 in CD4 + CD25 + cells is enabled by IL-2 .
20623548	0	CD4	62,65	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells involved|nmod|development involved|nsubjpass|END_ENTITY	IL-2 is positively involved in the development of colitogenic CD4 + IL-7R_alpha high memory T cells in chronic_colitis .
20702463	0	CD4	38,41	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	count|compound|START_ENTITY impact|nmod|count therapy|dep|impact therapy|compound|END_ENTITY	IL-2 therapy : potential impact of the CD4 cell count at initiation on clinical efficacy -- results from the ANRS CO4 cohort .
20856822	0	CD4	14,17	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	help|compound|START_ENTITY mediates|dobj|help mediates|nsubj|END_ENTITY	IL-2 mediates CD4 + T cell help in the breakdown of memory-like CD8 + T cell tolerance under lymphopenic conditions .
21059770	0	CD4	23,26	IL-2	73,77	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	T|compound|START_ENTITY IFN-y|nmod|T cells|amod|IFN-y Production|nmod|cells dependent|nsubj|Production dependent|advmod|END_ENTITY	Production of IFN-y by CD4 -LRB- + -RRB- T cells in response to malaria antigens is IL-2 dependent .
21107839	0	CD4	63,66	IL-2	112,116	CD4	IL-2	920	3558	Gene	Gene	cells|nmod|START_ENTITY cells|dep|cells cells|acl|using using|dobj|cytokines cytokines|dep|END_ENTITY	Expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from cord blood CD4 -LRB- + -RRB- cells using the common y-chain cytokines -LRB- IL-2 and IL-15 -RRB- and rapamycin .
21112091	0	CD4	16,19	IL-2	46,50	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|dobj|expression expression|compound|END_ENTITY	Human activated CD4 -LRB- + -RRB- T lymphocytes increase IL-2 expression by downregulating microRNA-181c .
21350367	0	CD4	43,46	IL-2	27,31	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY therapy|nmod|cells therapy|compound|END_ENTITY	The effect of intermittent IL-2 therapy on CD4 T cells in the gut in HIV-1-infected patients .
21389253	0	CD4	50,53	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY balance|nmod|cells maintaining|dobj|balance contributes|advcl|maintaining contributes|nsubj|END_ENTITY	IL-2 contributes to maintaining a balance between CD4 + Foxp3 + regulatory T cells and effector CD4 + T cells required for immune control of blood-stage malaria_infection .
21469091	0	CD4	83,86	IL-2	8,12	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY increase|nmod|cells leads|nmod|increase leads|nsubj|expression expression|compound|END_ENTITY	Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3 + CD4 + T cells with limited suppressor activity .
21502514	0	CD4	0,3	IL-2	88,92	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY control|nsubj|cells control|dobj|differentiation differentiation|nmod|homeostasis homeostasis|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasis .
21876034	0	CD4	44,47	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	IL-2 regulates expression of C-MAF in human CD4 T cells .
22216206	0	CD4	66,69	IL-2	37,41	CD4	IL-2	407098(Tax:9913)	280822(Tax:9913)	Gene	Gene	cells|compound|START_ENTITY reveals|dobj|cells reveals|nsubj|Development Development|nmod|antibody antibody|nmod|END_ENTITY	Development of an antibody to bovine IL-2 reveals multifunctional CD4 T -LRB- EM -RRB- cells in cattle naturally infected with bovine_tuberculosis .
22246628	0	CD4	42,45	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	IL-2 upregulates CD86 expression on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
22276195	0	CD4	28,31	IL-2	114,118	CD4	IL-2	920	3558	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 +|nmod|expansion +|nmod|administration administration|compound|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22461525	0	CD4	80,83	IL-2	47,51	CD4	IL-2	920	3558	Gene	Gene	cells|amod|START_ENTITY induces|nmod|cells induces|dobj|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
22516956	0	CD4	163,166	IL-2	114,118	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells expansion|dep|role expansion|nmod|cells cells|nmod|partial partial|nmod|receptor receptor|compound|END_ENTITY	Preferential expansion of human virus-specific multifunctional central memory T cells by partial targeting of the IL-2 receptor signaling pathway : the key role of CD4 + T cells .
22585398	0	CD4	50,53	IL-2	15,19	CD4	IL-2	920	3558	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	miR-9 enhances IL-2 production in activated human CD4 -LRB- + -RRB- T cells by repressing Blimp-1 .
22682297	0	CD4	39,42	IL-2	9,13	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ +|nmod|expansion +|nsubj|END_ENTITY	Low-dose IL-2 for In vivo expansion of CD4 + and CD8 + regulatory T cells in nonhuman primates .
22984435	0	CD4	24,27	IL-2	104,108	CD4	IL-2	920	3558	Gene	Gene	function|compound|START_ENTITY function|dep|vitro vitro|nmod|delivery delivery|nmod|END_ENTITY	Dendritic cells control CD4 + CD25 + Treg cell suppressor function in vitro through juxtacrine delivery of IL-2 .
23126599	0	CD4	56,59	IL-2	83,87	CD4	IL-2	920	3558	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nsubj|induction	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
23418630	0	CD4	30,33	IL-2	98,102	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells defined|nsubj|expansion defined|nmod|expression expression|nmod|receptors receptors|compound|END_ENTITY	Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors .
23526940	0	CD4	49,52	IL-2	19,23	CD4	IL-2	920	3558	Gene	Gene	responses|compound|START_ENTITY Increase|nmod|responses Increase|nmod|cells cells|amod|END_ENTITY	Increase in IFNy -LRB- - -RRB- IL-2 -LRB- + -RRB- cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza .
24281729	0	CD4	35,38	IL-2	18,22	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of IL-2 and IL-4 in CD4 -LRB- + -RRB- T cells from mouse lymph nodes and spleen during HSV-1-induced facial_palsy .
24291244	0	CD4	45,48	IL-2	28,32	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Promoter|nmod|cells Promoter|compound|END_ENTITY	Active demethylation of the IL-2 Promoter in CD4 + T cells is mediated by an inducible DNA glycosylase , Myh .
24586481	0	CD4	63,66	IL-2	22,26	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells differentiation|amod|driven driven|amod|END_ENTITY	Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells .
24587342	0	CD4	55,58	IL-2	41,45	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells .
24989679	0	CD4	33,36	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	Memory|compound|START_ENTITY Generation|nmod|Memory Inhibited|dobj|Generation Inhibited|dep|END_ENTITY	IL-2 Inhibited the Generation of CD4 -LRB- + -RRB- Memory T Cells .
2523423	0	CD4	34,37	IL-2	8,12	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ END_ENTITY|nmod|generation	Role of IL-2 in the generation of CD4 + suppressors of human B cell responsiveness .
2523864	0	CD4	160,163	IL-2	145,149	CD4	IL-2	920	3558	Gene	Gene	+45|compound|START_ENTITY R|nummod|+45 activated|dobj|R END_ENTITY|acl|activated	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	CD4	160,163	IL-2	80,84	CD4	IL-2	920	3558	Gene	Gene	+45|compound|START_ENTITY R|nummod|+45 activated|dobj|R IL-2|acl|activated restricted|nmod|IL-2 promoted|advcl|restricted promoted|nmod|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	CD4	23,26	IL-2	145,149	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY Proliferation|nmod|+ T|nsubj|Proliferation T|parataxis|promoted promoted|advcl|restricted restricted|nmod|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	CD4	23,26	IL-2	80,84	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY Proliferation|nmod|+ T|nsubj|Proliferation T|parataxis|promoted promoted|nmod|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
25369785	0	CD4	9,12	IL-2	98,102	CD4	IL-2	920	3558	Gene	Gene	transition|compound|START_ENTITY requires|nsubj|transition requires|dobj|interactions interactions|acl:relcl|induce induce|dobj|END_ENTITY	Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2 .
25491339	0	CD4	52,55	IL-2	15,19	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY Suppression|nmod|T Suppression|nmod|Production Production|compound|END_ENTITY	Suppression of IL-2 Production and Proliferation of CD4 -LRB- + -RRB- T Cells by Tuberostemonine O. Tuberostemonine stereoisomers are natural alkaloids found in Stemona tuberosa , that are known to have anti-inflammatory and anti-infective properties .
25578385	0	CD4	102,105	IL-2	46,50	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	T|compound|START_ENTITY enhances|nmod|T enhances|dobj|production production|compound|END_ENTITY	Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-y production by Toxoplasma_gondii-reactive CD4 -LRB- + -RRB- T cells .
2568977	0	CD4	79,82	IL-2	0,4	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	CD8|dep|START_ENTITY co-modulate|nmod|CD8 co-modulate|nsubj|END_ENTITY	IL-2 and IL-4 can co-modulate the generation of cytotoxic T cells through CD8 - CD4 - splenic lymphocytes .
2572284	0	CD4	161,164	IL-2	99,103	CD4	IL-2	920	3558	Gene	Gene	synthesize|nmod|START_ENTITY synthesize|dobj|interleukin-2 interleukin-2|appos|END_ENTITY	T-cell ontogeny after autologous bone marrow transplantation : failure to synthesize interleukin-2 -LRB- IL-2 -RRB- and lack of CD2 - and CD3-mediated proliferation by both CD4 - and CD8 + cells even in the presence of exogeneous IL-2 .
26062998	0	CD4	107,110	IL-2	79,83	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Plays|nmod|Cells Plays|dobj|Role Role|nmod|Production Production|compound|END_ENTITY	Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4 + Conventional T Cells .
26320249	0	CD4	31,34	IL-2	42,46	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	Severity|compound|START_ENTITY Severity|compound|END_ENTITY	Intrinsic Differences in Donor CD4 T Cell IL-2 Production Influence Severity of Parent-into-F1 Murine Lupus by Skewing the Immune Response Either toward Help for B Cells and a Sustained Autoantibody Response or toward Help for CD8 T Cells and a Downregulatory Th1 Response .
26886923	0	CD4	50,53	IL-2	99,103	CD4	IL-2	920	3558	Gene	Gene	Cells|compound|START_ENTITY Analysis|nmod|Cells Analysis|nmod|END_ENTITY	Comparative Analysis of Protocols to Induce Human CD4 + Foxp3 + Regulatory T Cells by Combinations of IL-2 , TGF-beta , Retinoic_Acid , Rapamycin and Butyrate .
27049955	0	CD4	78,81	IL-2	47,51	CD4	IL-2	920	3558	Gene	Gene	Suppression|compound|START_ENTITY Production|dep|Suppression Production|nsubj|Signaling Signaling|nmod|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27053558	0	CD4	21,24	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	Regulation|compound|START_ENTITY Induces|dobj|Regulation Induces|nsubj|Therapy Therapy|compound|END_ENTITY	IL-2 Therapy Induces CD4 Down Regulation in African_Green_Monkeys which Decreases Circulating CD4 T Cell Counts .
27053558	0	CD4	94,97	IL-2	0,4	CD4	IL-2	920	3558	Gene	Gene	Cell|compound|START_ENTITY Counts|nsubj|Cell Regulation|acl:relcl|Counts Induces|dobj|Regulation Induces|nsubj|Therapy Therapy|compound|END_ENTITY	IL-2 Therapy Induces CD4 Down Regulation in African_Green_Monkeys which Decreases Circulating CD4 T Cell Counts .
2969394	0	CD4	72,75	IL-2	27,31	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY Simultaneous|nmod|+ Simultaneous|dobj|production production|nmod|END_ENTITY	Simultaneous production of IL-2 , IL-4 , and IFN-gamma by activated human CD4 + and CD8 + T cell clones .
2972776	0	CD4	13,16	IL-2	36,40	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+8|compound|START_ENTITY +8|parataxis|produce produce|xcomp|END_ENTITY	Athymic nude CD4 +8 - T cells produce IL-2 but fail to proliferate in response to mitogenic stimuli .
2976621	0	CD4	77,80	IL-2	23,27	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|expression expression|compound|END_ENTITY	Nickel antigen induces IL-2 secretion and IL-2_receptor expression mainly on CD4 + T cells , but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel .
3263434	0	CD4	27,30	IL-2	68,72	CD4	IL-2	24932(Tax:10116)	116562(Tax:10116)	Gene	Gene	-|compound|START_ENTITY thymocytes|appos|- express|nsubj|thymocytes express|dobj|receptors receptors|compound|END_ENTITY	Immature , double_negative -LRB- CD4 - , CD8 - -RRB- rat thymocytes do not express IL-2 receptors .
7522522	1	CD4	115,118	IL-2	79,83	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY Analysis|nmod|+ Analysis|nmod|production production|compound|END_ENTITY	V. Analysis of IL-2 and IFN production by isolated CD4 + and CD8 + cells .
7586680	0	CD4	56,59	IL-2	38,42	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY Alterations|nmod|cells Alterations|dep|END_ENTITY	Alterations in interleukin secretion -LRB- IL-2 and IL-4 -RRB- by CD4 and CD4 CD45RO cells from common variable immunodeficiency -LRB- CVI -RRB- patients .
7819141	0	CD4	58,61	IL-2	88,92	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY IL-4|nmod|cells cAMP|dobj|IL-4 cAMP|advcl|decreasing decreasing|dobj|release release|compound|END_ENTITY	cAMP up-regulates IL-4 and IL-5 production from activated CD4 + T cells while decreasing IL-2 release and NF-AT induction .
7868930	0	CD4	1,4	IL-2	92,96	CD4	IL-2	920	3558	Gene	Gene	TIL|compound|START_ENTITY induce|nsubj|TIL induce|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	-LSB- CD4 TIL -LRB- Tumor_Infiltrating_Lymphocytes -RRB- induce complete response in patients treated with IL-2 -LRB- Interleukin-2 -RRB- .
7901148	0	CD4	35,38	IL-2	103,107	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY immunity|nmod|+ Transfer|nmod|immunity activated|nsubj|Transfer activated|nmod|therapy therapy|compound|END_ENTITY	Transfer of tumor immunity by both CD4 + and CD8 + tumor infiltrating T lymphocytes activated in vivo by IL-2 therapy of tumor bearing mice .
7901231	0	CD4	111,114	IL-2	23,27	CD4	IL-2	920	3558	Gene	Gene	differentiation|compound|START_ENTITY abnormality|nmod|differentiation due|nmod|abnormality due|nsubj|production production|compound|interleukin-2 interleukin-2|appos|END_ENTITY	Reduced interleukin-2 -LRB- IL-2 -RRB- production in common variable immunodeficiency is due to a primary abnormality of CD4 + T cell differentiation .
7902374	0	CD4	21,24	IL-2	67,71	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|nmod|secretion secretion|nmod|END_ENTITY	Subsets of activated CD4 T lymphocytes refractory for secretion of IL-2 are distinguished by expression of Ly-6A / E in BALB/c mice .
7930607	0	CD4	25,28	IL-2	49,53	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells depends|nsubj|production depends|nmod|END_ENTITY	IL-9 production of naive CD4 + T cells depends on IL-2 , is synergistically enhanced by a combination of TGF-beta and IL-4 , and is inhibited by IFN-gamma .
8327861	0	CD4	50,53	IL-2	13,17	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY Secretion|nmod|+ Secretion|nmod|END_ENTITY	Secretion of IL-2 , IL-3 , IL-4 , IL-6 and GM-CSF by CD4 + and CD8 + TCR alpha beta + T-cell clones derived early after allogeneic bone marrow transplantation .
8409385	0	CD4	44,47	IL-2	94,98	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY activity|nmod|+ activity|nmod|END_ENTITY	Cytolytic activity of murine IL-2-producing CD4 + and CD8 + T cell clones cycles in response to IL-2 .
8589277	0	CD4	21,24	IL-2	78,82	CD4	IL-2	920	3558	Gene	Gene	+|compound|START_ENTITY Generation|nmod|+ Generation|dep|lymphocytes lymphocytes|acl|activated activated|nmod|END_ENTITY	Generation of memory CD4 + , CD8 + , CD45RO + and CD16 - lymphocytes activated with IL-2 , INF-gamma , and TNF-alpha with specific cytotoxicity against autologous_cervical_cancer cells in a mixed leukocyte-tumour cell culture .
8595373	0	CD4	58,61	IL-2	20,24	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Distinct pattern of IL-2 and IFN-gamma gene expression in CD4 and CD8 T cells : cytofluorometric analysis at a single cell level using non-radioactive probes .
8666775	0	CD4	36,39	IL-2	73,77	CD4	IL-2	920	3558	Gene	Gene	45RO|compound|START_ENTITY activation|nmod|45RO activation|dep|cells cells|nmod|END_ENTITY	TCR-independent activation of human CD4 + 45RO - T cells by anti-CD28 plus IL-2 : Induction of clonal expansion and priming for a Th2 phenotype .
8675229	0	CD4	99,102	IL-2	84,88	CD4	IL-2	920	3558	Gene	Gene	T|compound|START_ENTITY T|amod|dependent dependent|amod|END_ENTITY	Growth regulatory effects of transforming_growth_factor-beta_1 and interleukin-2 on IL-2 dependent CD4 + T lymphoblastoid cell line .
8748254	0	CD4	41,44	IL-2	84,88	CD4	IL-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY act|nsubj|cells act|nmod|production production|compound|END_ENTITY	Mycobacterium bovis BCG-induced Th1 type CD4 + suppressor T cells act by suppressing IL-2 production and IL-2_receptor expression .
8786299	0	CD4	63,66	IL-2	10,14	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY priming|nmod|cells enhance|dobj|priming enhance|nsubj|END_ENTITY	High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4 + T cells for IFN-gamma but have differential effects on priming for IL-4 .
9521080	0	CD4	46,49	IL-2	108,112	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|acl:relcl|mediates mediates|dobj|signal signal|nmod|secretion secretion|nmod|END_ENTITY	A T cell activation antigen , Ly6C , induced on CD4 + Th1 cells mediates an inhibitory signal for secretion of IL-2 and proliferation in peripheral immune responses .
9590250	0	CD4	0,3	IL-2	104,108	CD4	IL-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|requirements requirements|nmod|END_ENTITY	CD4 + and CD8 + T cell interactions in IFN-gamma and IL-4 responses to viral_infections : requirements for IL-2 .
9636688	0	CD4	24,27	IL-2	53,57	CD4	IL-2	920	3558	Gene	Gene	mAb|compound|START_ENTITY inhibits|nsubj|mAb inhibits|dobj|END_ENTITY	A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2 , IL-4 , and IL-10 secretion and expression of CD25 , CD40L , and CD69 .
9794390	0	CD4	94,97	IL-2	33,37	CD4	IL-2	920	3558	Gene	Gene	cells|compound|START_ENTITY Evidence|nmod|cells Evidence|nmod|role role|nmod|END_ENTITY	Evidence for a critical role for IL-2 in CD40-mediated activation of naive B cells by primary CD4 T cells .
17202333	0	CD4	70,73	IL-21	0,5	CD4	IL-21	920	59067	Gene	Gene	lymphocytes|compound|START_ENTITY suppression|nmod|lymphocytes counteracts|dobj|suppression counteracts|nsubj|END_ENTITY	IL-21 counteracts the regulatory T cell-mediated suppression of human CD4 + T lymphocytes .
17698559	0	CD4	105,108	IL-21	55,60	CD4	IL-21	920	59067	Gene	Gene	subsets|compound|START_ENTITY proliferation|nmod|subsets effect|nmod|proliferation END_ENTITY|dep|effect	Human CD4 + central and effector memory T cells produce IL-21 : effect on cytokine-driven proliferation of CD4 + T cell subsets .
17698559	0	CD4	6,9	IL-21	55,60	CD4	IL-21	920	59067	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|END_ENTITY	Human CD4 + central and effector memory T cells produce IL-21 : effect on cytokine-driven proliferation of CD4 + T cell subsets .
17947662	0	CD4	91,94	IL-21	18,23	CD4	IL-21	920	59067	Gene	Gene	collaboration|compound|START_ENTITY role|nmod|collaboration role|nmod|END_ENTITY	Essential role of IL-21 in B cell activation , expansion , and plasma cell generation during CD4 + T cell-B cell collaboration .
18052963	0	CD4	16,19	IL-21	0,5	CD4	IL-21	12504(Tax:10090)	60505(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY modulates|dobj|CD25 modulates|nsubj|END_ENTITY	IL-21 modulates CD4 + CD25 + regulatory T-cell homeostasis in experimental_autoimmune_encephalomyelitis .
18788946	0	CD4	86,89	IL-21	32,37	CD4	IL-21	920	59067	Gene	Gene	counts|compound|START_ENTITY correlation|nmod|counts levels|dep|correlation levels|acl|circulating circulating|dobj|END_ENTITY	Decreased levels of circulating IL-21 in HIV-infected AIDS patients : correlation with CD4 + T-cell counts .
19139170	0	CD4	89,92	IL-21	71,76	CD4	IL-21	920	59067	Gene	Gene	cells|compound|START_ENTITY produced|nmod|cells END_ENTITY|acl|produced	The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4 + T cells .
19342640	0	CD4	68,71	IL-21	28,33	CD4	IL-21	12504(Tax:10090)	60505(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY provoked|nmod|CD25 provoked|nsubj|loop loop|nmod|signaling signaling|compound|END_ENTITY	A positive feedback loop of IL-21 signaling provoked by homeostatic CD4 + CD25 - T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice .
21055341	0	CD4	28,31	IL-21	33,38	CD4	IL-21	920	59067	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Characterization of memory CD4 + IL-21 + T cells in human PBMC -RSB- .
21419052	0	CD4	29,32	IL-21	13,18	CD4	IL-21	920	59067	Gene	Gene	induced|nmod|START_ENTITY induced|dobj|levels levels|compound|END_ENTITY	-LSB- The induced IL-21 levels in CD4 -LRB- + -RRB- T cells of peripheral blood from the different clinical types of patients infected with hepatitis_B_virus -RSB- .
21441456	0	CD4	35,38	IL-21	0,5	CD4	IL-21	12504(Tax:10090)	60505(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY recruitment|nmod|cells promotes|dobj|recruitment promotes|nsubj|END_ENTITY	IL-21 promotes skin recruitment of CD4 -LRB- + -RRB- cells and drives IFN-y-dependent epidermal_hyperplasia .
22491065	0	CD4	40,43	IL-21	14,19	CD4	IL-21	920	59067	Gene	Gene	cells|compound|START_ENTITY triggers|nmod|cells triggers|dobj|production production|compound|END_ENTITY	IL-6 triggers IL-21 production by human CD4 + T cells to drive STAT3-dependent plasma cell differentiation in B cells .
22723520	0	CD4	84,87	IL-21	0,5	CD4	IL-21	12504(Tax:10090)	60505(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY chronic_graft-versus-host_disease|nmod|cell mechanisms|amod|chronic_graft-versus-host_disease lupus-like_disease|nmod|mechanisms promotes|xcomp|lupus-like_disease promotes|nsubj|END_ENTITY	IL-21 promotes lupus-like_disease in chronic_graft-versus-host_disease through both CD4 T cell - and B cell-intrinsic mechanisms .
23168836	0	CD4	46,49	IL-21	11,16	CD4	IL-21	12504(Tax:10090)	59067	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV_disease in mice .
23493630	0	CD4	72,75	IL-21	52,57	CD4	IL-21	920	59067	Gene	Gene	cells|compound|START_ENTITY reduces|nmod|cells reduces|dobj|production production|compound|END_ENTITY	Interleukin-6_receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid_arthritis .
24470500	0	CD4	15,18	IL-21	0,5	CD4	IL-21	920	59067	Gene	Gene	responses|compound|START_ENTITY promotes|dobj|responses promotes|nsubj|END_ENTITY	IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells .
25281860	0	CD4	0,3	IL-21	61,66	CD4	IL-21	920	59067	Gene	Gene	CXCR5|compound|START_ENTITY T|nsubj|CXCR5 T|ccomp|produce produce|xcomp|END_ENTITY	CD4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- T cells in chronic HCV_infection produce less IL-21 , yet are efficient at supporting B cell responses .
25343703	0	CD4	37,40	IL-21	102,107	CD4	IL-21	920	59067	Gene	Gene	Frequencies|nmod|START_ENTITY +|nsubj|Frequencies +|dobj|Associated Associated|nmod|END_ENTITY	Decreased Frequencies of Circulating CD4 + T Follicular Helper Cells Associated with Diminished Plasma IL-21 in Active Pulmonary_Tuberculosis .
25492803	0	CD4	19,22	IL-21	0,5	CD4	IL-21	12504(Tax:10090)	60505(Tax:10090)	Gene	Gene	differentiation|compound|START_ENTITY induction|nmod|differentiation induction|compound|END_ENTITY	IL-21 induction of CD4 + T cell differentiation into Th17 cells contributes to bleomycin-induced fibrosis in mice .
25652388	0	CD4	20,23	IL-21	0,5	CD4	IL-21	920	59067	Gene	Gene	effector|compound|START_ENTITY production|nmod|effector production|compound|END_ENTITY	IL-21 production by CD4 -LRB- + -RRB- effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients .
25780036	0	CD4	0,3	IL-21	20,25	CD4	IL-21	920	59067	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|END_ENTITY	CD4 + T Cell-Derived IL-21 and Deprivation of CD40 Signaling Favor the In Vivo Development of Granzyme_B-Expressing Regulatory B Cells in HIV Patients .
26170288	0	CD4	55,58	IL-21	37,42	CD4	IL-21	920	59067	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells function|nsubj|roles roles|nmod|END_ENTITY	Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 + T cells .
26239551	0	CD4	22,25	IL-21	6,11	CD4	IL-21	920	59067	Gene	Gene	START_ENTITY|nsubj|IFN-y IFN-y|compound|END_ENTITY	Human IL-21 -LRB- + -RRB- IFN-y -LRB- + -RRB- CD4 -LRB- + -RRB- T cells in nasal_polyps are regulated by IL-12 .
26436852	0	CD4	12,15	IL-21	100,105	CD4	IL-21	920	59067	Gene	Gene	CXCR5|compound|START_ENTITY T|nsubj|CXCR5 T|xcomp|Production Production|dep|Secretion Secretion|compound|END_ENTITY	Circulating CD4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- T Cells Exacerbate B Cell Antibody Production in Crohn 's _ Disease Through IL-21 Secretion .
26818544	0	CD4	0,3	IL-21	50,55	CD4	IL-21	920	59067	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ activate|nsubj|cells activate|dobj|cells cells|nmod|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
27067007	0	CD4	73,76	IL-21	64,69	CD4	IL-21	920	59067	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|nmod|END_ENTITY	Dynamic Long-Range Chromatin Interaction Controls Expression of IL-21 in CD4 + T Cells .
20574002	0	CD4	17,20	IL-21R	41,47	CD4	IL-21R	920	50615	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Altered effector CD4 + T cell function in IL-21R - / - CD4 + T cell-mediated graft-versus-host_disease .
17088898	0	CD4	58,61	IL-22	29,34	CD4	IL-22	920	50616	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression and regulation of IL-22 in the IL-17-producing CD4 + T lymphocytes .
20231432	0	CD4	42,45	IL-22	23,28	CD4	IL-22	12504(Tax:10090)	50929(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Notch signaling drives IL-22 secretion in CD4 + T cells by stimulating the aryl_hydrocarbon_receptor .
20683099	0	CD4	54,57	IL-22	28,33	CD4	IL-22	920	50616	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Evaluation of the effect of IL-22 on human cord blood CD4 + T cells .
23266494	0	CD4	78,81	IL-22	13,18	CD4	IL-22	920	50616	Gene	Gene	T|compound|START_ENTITY production|nmod|T END_ENTITY|nmod|production	Depletion of IL-22 during culture enhanced antigen-driven IFN-y production by CD4 -LRB- + -RRB- T cells from patients with active TB .
23518141	0	CD4	30,33	IL-22	66,71	CD4	IL-22	920	50616	Gene	Gene	cells|compound|START_ENTITY cells|nmod|phenotype phenotype|compound|END_ENTITY	Human mast cells drive memory CD4 + T cells toward an inflammatory IL-22 + phenotype .
23576801	0	CD4	6,9	IL-22	0,5	CD4	IL-22	920	50616	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	IL-22 + CD4 + T-cells in patients with active systemic_lupus_erythematosus .
23589614	0	CD4	30,33	IL-22	64,69	CD4	IL-22	920	50616	Gene	Gene	START_ENTITY|dep|population population|dep|produces produces|dobj|END_ENTITY	Intestinal Lin - c-Kit + NKp46 - CD4 - population strongly produces IL-22 upon IL-1b stimulation .
23692034	0	CD4	0,3	IL-22	46,51	CD4	IL-22	920	50616	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|cells cells|nsubj|cells cells|acl|producing producing|dobj|-17 -17|amod|END_ENTITY	CD4 -LRB- + -RRB- T cells producing interleukin _ -LRB- IL -RRB- -17 , IL-22 and interferon-y are major effector T cells in nickel allergy .
23726764	0	CD4	16,19	IL-22	0,5	CD4	IL-22	920	50616	Gene	Gene	cells|nummod|START_ENTITY secreting|dobj|cells END_ENTITY|acl|secreting	IL-22 secreting CD4 + T cells in the patients with neuromyelitis_optica and multiple_sclerosis .
23727477	0	CD4	50,53	IL-22	35,40	CD4	IL-22	920	50616	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	IL-27 suppresses the production of IL-22 in human CD4 -LRB- + -RRB- T cells by inducing the expression of SOCS1 .
25148371	0	CD4	113,116	IL-22	71,76	CD4	IL-22	920	50616	Gene	Gene	T-cells|compound|START_ENTITY induces|nmod|T-cells induces|dobj|production production|amod|END_ENTITY	TL1A increases expression of CD25 , LFA-1 , CD134 and CD154 , and induces IL-22 and GM-CSF production from effector CD4 T-cells .
18606706	0	CD4	67,70	IL-23	0,5	CD4	IL-23	12504(Tax:10090)	83430(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	IL-23 induces receptor activator of NF-kappaB ligand expression on CD4 + T cells and promotes osteoclastogenesis in an autoimmune_arthritis model .
12121660	0	CD4	97,100	IL-27	0,5	CD4	IL-27	920	246778	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells induces|dobj|proliferation induces|nsubj|END_ENTITY	IL-27 , a heterodimeric cytokine composed of EBI3 and p28 protein , induces proliferation of naive CD4 + T cells .
19596985	0	CD4	46,49	IL-27	0,5	CD4	IL-27	12504(Tax:10090)	246779(Tax:10090)	Gene	Gene	pool|compound|START_ENTITY homeostasis|nmod|pool regulates|dobj|homeostasis regulates|nsubj|END_ENTITY	IL-27 regulates homeostasis of the intestinal CD4 + effector T cell pool and limits intestinal_inflammation in a murine model of colitis .
19748991	0	CD4	37,40	IL-27	0,5	CD4	IL-27	12504(Tax:10090)	246779(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	IL-27 regulates IL-10 and IL-17 from CD4 + cells in nonhealing Leishmania_major_infection .
21115047	0	CD4	69,72	IL-27	0,5	CD4	IL-27	920	246778	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	IL-27 induces the differentiation of Tr1-like cells from human naive CD4 + T cells via the phosphorylation of STAT1 and STAT3 .
21453726	0	CD4	37,40	IL-27	0,5	CD4	IL-27	920	246778	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells suppresses|dobj|expression suppresses|nsubj|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
21669870	0	CD4	89,92	IL-27	45,50	CD4	IL-27	920	246778	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells events|dep|proliferation events|acl|involved involved|nmod|interleukin_27 interleukin_27|appos|END_ENTITY	Signaling events involved in interleukin_27 -LRB- IL-27 -RRB- - induced proliferation of human naive CD4 + T cells and B cells .
22116827	0	CD4	7,10	IL-27	50,55	CD4	IL-27	920	246778	Gene	Gene	cells|compound|START_ENTITY induce|nsubj|cells induce|dobj|expression expression|nmod|END_ENTITY	Memory CD4 T cells induce selective expression of IL-27 in CD8 + dendritic cells and regulate homeostatic naive T cell proliferation .
23335749	0	CD4	68,71	IL-27	17,22	CD4	IL-27	12504(Tax:10090)	246779(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes .
23536628	0	CD4	35,38	IL-27	0,5	CD4	IL-27	12504(Tax:10090)	246779(Tax:10090)	Gene	Gene	responses|nummod|START_ENTITY regulates|dobj|responses regulates|nsubj|receptor receptor|compound|END_ENTITY	IL-27 receptor signaling regulates CD4 + T cell chemotactic responses during infection .
23727477	0	CD4	50,53	IL-27	0,5	CD4	IL-27	920	246778	Gene	Gene	T|compound|START_ENTITY IL-22|nmod|T cells|amod|IL-22 production|nmod|cells suppresses|dobj|production suppresses|nsubj|END_ENTITY	IL-27 suppresses the production of IL-22 in human CD4 -LRB- + -RRB- T cells by inducing the expression of SOCS1 .
23993651	0	CD4	84,87	IL-27	15,20	CD4	IL-27	920	246778	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4 T cell responses and viral control during chronic_infection .
26222157	0	CD4	116,119	IL-27	0,5	CD4	IL-27	12504(Tax:10090)	246779(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Effects|nmod|Cells Trypanosomes|nmod|Effects Infected|nmod|Trypanosomes Survival|nmod|Infected Crucial|nmod|Survival Crucial|nsubj|Signaling Signaling|compound|END_ENTITY	IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4 + T Cells and IFN-y .
26222157	0	CD4	116,119	IL-27	0,5	CD4	IL-27	12504(Tax:10090)	246779(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Effects|nmod|Cells Trypanosomes|nmod|Effects Infected|nmod|Trypanosomes Survival|nmod|Infected Crucial|nmod|Survival Crucial|nsubj|Signaling Signaling|compound|END_ENTITY	IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4 + T Cells and IFN-y .
20148705	0	CD4	41,44	IL-28A	14,20	CD4	IL-28A	920	282616	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	The effect of IL-28A on human cord blood CD4 + T cells .
1358556	0	CD4	47,50	IL-2R	16,21	CD4	IL-2R	920	3559	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	Distribution of IL-2R and CD45Ro expression on CD4 + and CD8 + T-lymphocytes in the peripheral blood of patients with posterior uveitis .
1469522	0	CD4	63,66	IL-2R	16,21	CD4	IL-2R	920	3559	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|levels levels|compound|END_ENTITY	Increased serum IL-2R levels in coeliac_disease are related to CD4 but not CD8 antigens .
15678692	0	CD4	75,78	IL-2R	22,27	CD4	IL-2R	920	3559	Gene	Gene	subset|compound|START_ENTITY proliferation|nmod|subset alters|dobj|proliferation alters|nsubj|system system|compound|END_ENTITY	Dysregulation of IL-2 / IL-2R system alters proliferation of early activated CD4 + T cell subset in patients with end-stage_renal_failure .
19875613	0	CD4	87,90	IL-2R	11,16	CD4	IL-2R	920	3560	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 maintenance|nmod|expression contribute|nmod|maintenance contribute|nsubj|Defects Defects|nmod|signaling signaling|compound|END_ENTITY	Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T-cells of type 1 diabetic subjects .
24376757	0	CD4	76,79	IL-2R	57,62	CD4	IL-2R	920	3560	Gene	Gene	CD25|compound|START_ENTITY signaling|nmod|CD25 END_ENTITY|acl|signaling	Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4 + CD25 -LRB- hi -RRB- T cells of type 1 diabetic and multiple_sclerosis patients .
8308269	0	CD4	19,22	IL-2R	31,36	CD4	IL-2R	920	3559	Gene	Gene	Isolation|dep|START_ENTITY thymocyte|advcl|Isolation thymocyte|nsubj|+ +|compound|END_ENTITY	Isolation of CD3 - , CD4 - , CD8 - , IL-2R + thymocyte precursors by panning .
12391195	0	CD4	114,117	IL-2R_alpha	40,51	CD4	IL-2R alpha	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	numbers|nummod|START_ENTITY controls|dobj|numbers population|acl:relcl|controls shape|dobj|population shape|nsubj|Homeostasis Homeostasis|nmod|cells cells|amod|END_ENTITY	Homeostasis of peripheral CD4 + T cells : IL-2R_alpha and IL-2 shape a population of regulatory cells that controls CD4 + T cell numbers .
12391195	0	CD4	26,29	IL-2R_alpha	40,51	CD4	IL-2R alpha	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Homeostasis of peripheral CD4 + T cells : IL-2R_alpha and IL-2 shape a population of regulatory cells that controls CD4 + T cell numbers .
1674955	0	CD4	103,106	IL-2R_alpha	63,74	CD4	IL-2R alpha	920	3559	Gene	Gene	cells|nummod|START_ENTITY chain|nmod|cells chain|amod|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
9620592	0	CD4	11,14	IL-2R_alpha	38,49	CD4	IL-2R alpha	12504(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|dep|expression expression|nmod|chain chain|compound|END_ENTITY	Regulatory CD4 T cells : expression of IL-2R_alpha chain , resistance to clonal deletion and IL-2 dependency .
24648606	0	CD4	60,63	IL-2_Receptor	35,48	CD4	IL-2 Receptor	920	3560	Gene	Gene	cells|compound|START_ENTITY pattern|nmod|cells pattern|nmod|b-chain b-chain|compound|END_ENTITY	Abnormal expression pattern of the IL-2_Receptor b-chain on CD4 + T cells in ANCA-associated vasculitis .
15100267	0	CD4	44,47	IL-2_receptor	9,22	CD4	IL-2 receptor	920	3560	Gene	Gene	CD25|compound|START_ENTITY pattern|nmod|CD25 signaling|dobj|pattern END_ENTITY|acl|signaling	Distinct IL-2_receptor signaling pattern in CD4 + CD25 + regulatory T cells .
15922716	0	CD4	96,99	IL-2_receptor	72,85	CD4	IL-2 receptor	920	3560	Gene	Gene	cells|compound|START_ENTITY Effects|nmod|cells Effects|dep|induction induction|nmod|CD25 CD25|appos|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
1900055	0	CD4	79,82	IL-2_receptor	27,40	CD4	IL-2 receptor	920	3560	Gene	Gene	+|compound|START_ENTITY subunits|nmod|+ subunits|nsubj|expression expression|nmod|END_ENTITY	Preferential expression of IL-2_receptor subunits on memory populations within CD4 + and CD8 + T cells .
1969884	2	CD4	67,70	IL-2_receptor	94,107	CD4	IL-2 receptor	920	3560	Gene	Gene	T|compound|START_ENTITY Down-regulation|nmod|T cells|nsubj|Down-regulation cells|dobj|expression expression|compound|END_ENTITY	Down-regulation of CD4 + T cells high-affinity IL-2_receptor expression .
19788505	0	CD4	86,89	IL-2_receptor	16,29	CD4	IL-2 receptor	920	3560	Gene	Gene	proliferation|nmod|START_ENTITY enhances|dobj|proliferation Disengaging|dep|enhances Disengaging|dobj|END_ENTITY	Disengaging the IL-2_receptor with daclizumab enhances IL-7-mediated proliferation of CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
8596025	0	CD4	89,92	IL-2_receptor	65,78	CD4	IL-2 receptor	920	3560	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential regulation of bcl-2 and bcl-x by CD3 , CD28 , and the IL-2_receptor in cloned CD4 + helper T cells .
9138018	0	CD4	63,66	IL-2_receptor	18,31	CD4	IL-2 receptor	920	3560	Gene	Gene	T|compound|START_ENTITY subunit|nmod|T subunit|compound|END_ENTITY	Expression of the IL-2_receptor gamma subunit in resting human CD4 T lymphocytes : mRNA is constitutively transcribed and the protein stored as an intracellular component .
25595785	0	CD4	63,66	IL-31	38,43	CD4	IL-31	12504(Tax:10090)	76399(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4 + T Cells in Health and Disease .
10227987	0	CD4	52,55	IL-4	176,180	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY alpha|dep|cells NK1.1-negative|appos|alpha exist|nsubj|NK1.1-negative exist|nmod|mice mice|nmod|capacity capacity|acl|secrete secrete|dobj|amounts amounts|nmod|END_ENTITY	Splenic NK1.1-negative , TCR alpha beta intermediate CD4 + T cells exist in naive NK1 .1 allelic positive and negative mice , with the capacity to rapidly secrete large amounts of IL-4 and IFN-gamma upon primary TCR stimulation .
10323213	0	CD4	105,108	IL-4	72,76	CD4	IL-4	920	3565	Gene	Gene	+|compound|START_ENTITY Differentiation|dep|+ Differentiation|nmod|thymocytes thymocytes|acl|vitro vitro|nmod|END_ENTITY	Differentiation of human single-positive fetal thymocytes in vitro into IL-4 - and/or IFN-gamma-producing CD4 + and CD8 + T cells .
10358149	0	CD4	94,97	IL-4	18,22	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY I-like/CD1-dependent|dep|T NK1|dep|I-like/CD1-dependent cells|amod|NK1 up-regulates|nmod|cells up-regulates|dobj|production production|compound|END_ENTITY	IL-7 up-regulates IL-4 production by splenic NK1 .1 + and NK1 .1 - MHC class I-like/CD1-dependent CD4 + T cells .
10358155	0	CD4	128,131	IL-4	103,107	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY required|nmod|cells required|nmod|production production|compound|END_ENTITY	p38_alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4 + CD45RO + T cells and Th2 effector cells .
10403909	0	CD4	60,63	IL-4	8,12	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nsubj|END_ENTITY	Reduced IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- expression by CD4 T cells in patients with chronic_lymphocytic_leukaemia .
10454344	0	CD4	107,110	IL-4	176,180	CD4	IL-4	407098(Tax:9913)	280824(Tax:9913)	Gene	Gene	+|compound|START_ENTITY responses|nmod|+ interleukin-12|nmod|responses effects|nmod|interleukin-12 T|nsubj|effects T|parataxis|enhances enhances|advcl|has has|nsubj|END_ENTITY	Comparative effects of interleukin-12 and interleukin-4 on cytokine responses by antigen-stimulated memory CD4 + T cells of cattle : IL-12 enhances IFN-gamma production , whereas IL-4 has marginal effects on cytokine expression .
10465051	0	CD4	0,3	IL-4	67,71	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|END_ENTITY	CD4 + and/or gammadelta + T cells in the liver spontaneously produce IL-4 in vitro during the early phase of Leishmania_major_infection in susceptible BALB/c mice .
10549628	0	CD4	13,16	IL-4	95,99	CD4	IL-4	920	3565	Gene	Gene	T|compound|START_ENTITY T|acl:relcl|protect protect|xcomp|using using|dobj|END_ENTITY	Autoreactive CD4 + T cells protect from autoimmune diabetes via bystander suppression using the IL-4 / Stat6 pathway .
10706693	0	CD4	123,126	IL-4	34,38	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ development|nmod|lymphocytes required|nmod|development required|nsubjpass|receptor/Stat6 receptor/Stat6|compound|END_ENTITY	Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4 + lymphocytes with a Th2 cytokine profile .
10789989	0	CD4	69,72	IL-4	104,108	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Immunoregulation|nmod|cells involves|nsubj|Immunoregulation involves|dobj|END_ENTITY	Immunoregulation of encephalitogenic MBP-NAc1-11-reactive T cells by CD4 + TCR-specific T cells involves IL-4 , IL-10 and IFN-gamma .
10975998	0	CD4	61,64	IL-4	30,34	CD4	IL-4	920	3565	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Modulatory roles of RANTES in IL-4 production by human blood CD4 -LRB- + -RRB- T cells .
11034364	0	CD4	20,23	IL-4	62,66	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	naive|dep|START_ENTITY cells|amod|naive provide|nsubj|cells provide|dobj|source source|nmod|END_ENTITY	Conventional , naive CD4 + T cells provide an initial source of IL-4 during Th2 differentiation .
11067920	0	CD4	82,85	IL-4	114,118	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|secrete secrete|dobj|END_ENTITY	Priming by microbial antigens from the intestinal flora determines the ability of CD4 + T cells to rapidly secrete IL-4 in BALB/c mice infected with Leishmania_major .
11359851	0	CD4	27,30	IL-4	129,133	CD4	IL-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY CCR4|nmod|cells defines|nsubj|CCR4 defines|dobj|subset subset|nmod|cells cells|nmod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11449377	0	CD4	131,134	IL-4	50,54	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cytokines|nmod|cells regulates|nmod|cytokines polarization|parataxis|regulates polarization|nmod|absence absence|nmod|END_ENTITY	Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12 : T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells .
11751746	0	CD4	61,64	IL-4	4,8	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY strains|nmod|T capability|nmod|strains capability|compound|END_ENTITY	The IL-4 production capability of different strains of naive CD4 -LRB- + -RRB- T cells controls the direction of the T -LRB- h -RRB- cell response .
11781715	0	CD4	65,68	IL-4	25,29	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY transcription|nmod|cells transcription|compound|END_ENTITY	Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells .
11796615	0	CD4	47,50	IL-4	130,134	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	lymphocytes|dep|START_ENTITY lymphocytes|dep|induction induction|nmod|END_ENTITY	Fas_ligand-expressing B-1a lymphocytes mediate CD4 -LRB- + -RRB- - T-cell apoptosis during schistosomal_infection : induction by interleukin_4 -LRB- IL-4 -RRB- and IL-10 .
11859105	0	CD4	65,68	IL-4	115,119	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generates|dobj|cells generates|xcomp|expressing expressing|dobj|END_ENTITY	Administration of an antigen at a high dose generates regulatory CD4 + T cells expressing CD95 ligand and secreting IL-4 in the liver .
11971011	0	CD4	72,75	IL-4	6,10	CD4	IL-4	920	3565	Gene	Gene	homolog|nmod|START_ENTITY production|nmod|homolog production|compound|END_ENTITY	Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4 -LRB- + -RRB- T cells in resistant mice treated once with anti-IL-12 or - IFN-gamma antibodies at the onset of infection with Leishmania_major instructs Th2 cell development , resulting in nonhealing lesions .
11971026	0	CD4	76,79	IL-4	36,40	CD4	IL-4	920	3565	Gene	Gene	eosinophils|nmod|START_ENTITY release|nmod|eosinophils release|compound|END_ENTITY	IL-16 promotes leukotriene_C -LRB- 4 -RRB- and IL-4 release from human eosinophils via CD4 - and autocrine CCR3-chemokine-mediated signaling .
11981811	0	CD4	91,94	IL-4	121,125	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY dependent|nmod|cells dependent|nmod|source source|nmod|END_ENTITY	Th2-type granuloma development in acute murine schistosomiasis is only partly dependent on CD4 + T cells as the source of IL-4 .
11981831	0	CD4	36,39	IL-4	0,4	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	acts|compound|START_ENTITY secreted|nmod|acts secreted|nsubj|END_ENTITY	IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation .
12218142	0	CD4	167,170	IL-4	10,14	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY control|nmod|cells subject|nmod|control subject|nsubj|response response|compound|END_ENTITY	The early IL-4 response to Leishmania_major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 + CD25 + T cells .
12220104	0	CD4	25,28	IL-4	122,126	CD4	IL-4	920	3565	Gene	Gene	Characterization|nmod|START_ENTITY T|nsubj|Characterization T|dobj|cells cells|dep|production production|nmod|END_ENTITY	Characterization of CD3 + CD4 - CD8 - -LRB- double negative -RRB- T cells in patients with systemic_lupus_erythematosus : production of IL-4 .
12444170	0	CD4	62,65	IL-4	47,51	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY Th2|acl:relcl|cell Th2|appos|IFN-gamma IFN-gamma|dep|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12534941	0	CD4	16,19	IL-4	0,4	CD4	IL-4	24932(Tax:10116)	287287(Tax:10116)	Gene	Gene	responsive|dep|START_ENTITY END_ENTITY|amod|responsive	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
12568118	0	CD4	25,28	IL-4	10,14	CD4	IL-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells END_ENTITY|acl|producing	Decreased IL-4 producing CD4 + T cells in patients with active systemic_lupus_erythematosus-relation to IL-12R expression .
12594266	0	CD4	121,124	IL-4	96,100	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Role of TCR-induced extracellular_signal-regulated_kinase activation in the regulation of early IL-4 expression in naive CD4 + T cells .
12848849	0	CD4	115,118	IL-4	97,101	CD4	IL-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY synthesizing|dobj|cells required|xcomp|synthesizing required|nmod|development development|nmod|END_ENTITY	Sustained linked stimulation via CD3 and CD4 is required for the IL-4-independent development of IL-4 synthesizing CD4 + T cells .
1353098	0	CD4	46,49	IL-4	38,42	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	type|compound|START_ENTITY respond|nmod|type respond|nmod|END_ENTITY	Induction of competence to respond to IL-4 by CD4 + T helper type 1 cells requires costimulation .
1357029	0	CD4	69,72	IL-4	40,44	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4 + cells correlate with resolution of lesions in murine cutaneous_leishmaniasis .
1361075	0	CD4	23,26	IL-4	53,57	CD4	IL-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|presence presence|nmod|END_ENTITY	Primary stimulation of CD4 + cells in the presence of IL-4 or IFN-gamma alters the frequencies of cytokine-producing cells at restimulation .
15326095	0	CD4	75,78	IL-4	0,4	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|compound|START_ENTITY initiate|dobj|+ impair|advcl|initiate impair|nsubj|deficiency deficiency|compound|END_ENTITY	IL-4 deficiency does not impair the ability of dendritic cells to initiate CD4 + and CD8 + T cell responses in vivo .
15944265	0	CD4	19,22	IL-4	0,4	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY modulation|nmod|suppression modulation|compound|END_ENTITY	IL-4 modulation of CD4 + CD25 + T regulatory cell-mediated suppression .
16237062	0	CD4	195,198	IL-4	165,169	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY increase|nmod|cells increase|dobj|expression expression|compound|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- deficiency in macrophages results in increased stimulation of CD4 + T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4 + T cells independent of antigen presentation .
16237062	0	CD4	96,99	IL-4	165,169	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY stimulation|nmod|cells results|nmod|stimulation deficiency|nmod|results deficiency|advcl|increase increase|dobj|expression expression|compound|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- deficiency in macrophages results in increased stimulation of CD4 + T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4 + T cells independent of antigen presentation .
16237107	0	CD4	104,107	IL-4	4,8	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induce|dobj|cells alpha-chain-binding|ccomp|induce alpha-chain-binding|nsubj|receptor receptor|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16237107	0	CD4	104,107	IL-4	49,53	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induce|dobj|cells induce|nsubj|cytokines cytokines|appos|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16272288	0	CD4	17,20	IL-4	29,33	CD4	IL-4	920	3565	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Morphine induces CD4 + T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway .
1674955	0	CD4	103,106	IL-4	0,4	CD4	IL-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY chain|nmod|cells synthesis|nmod|chain inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
16806176	0	CD4	123,126	IL-4	91,95	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY pathway|nmod|T cells|amod|pathway signaling|dobj|cells dependent|xcomp|signaling dependent|nmod|STAT6 STAT6|compound|END_ENTITY	Immune-mediated neuroprotection of axotomized mouse facial_motoneurons is dependent on the IL-4 / STAT6 signaling pathway in CD4 -LRB- + -RRB- T cells .
17035345	0	CD4	124,127	IL-4	99,103	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY controlling|nmod|cells controlling|dobj|capacity capacity|nmod|production production|compound|END_ENTITY	Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4 + T cells .
17075267	0	CD4	16,19	IL-4	55,59	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY cells|nsubj|T cells|dobj|downregulation downregulation|nmod|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
17085308	0	CD4	61,64	IL-4	40,44	CD4	IL-4	24932(Tax:10116)	287287(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY polarized|dobj|cells polarized|nsubj|END_ENTITY	Phase I clinical trial of costimulated , IL-4 polarized donor CD4 + T cells as augmentation of allogeneic hematopoietic cell transplantation .
17237387	0	CD4	32,35	IL-4	13,17	CD4	IL-4	920	3565	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of IL-4 expression in CD4 -LRB- + -RRB- T cells by thymic stromal lymphopoietin .
17404269	0	CD4	106,109	IL-4	87,91	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Type|nmod|cells Type|dobj|mediation mediation|nmod|generation generation|compound|END_ENTITY	Type 1 sphingosine_1-phosphate G protein-coupled receptor -LRB- S1P1 -RRB- mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic_mice .
17404901	0	CD4	39,42	IL-4	0,4	CD4	IL-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY ve|dobj|cells inducibility|xcomp|ve inducibility|nsubj|END_ENTITY	IL-4 inducibility in NKT cells , na ve CD4 + T cells and TCR-gamma delta T cells .
17675505	0	CD4	105,108	IL-4	69,73	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY reveal|dobj|cells reveal|nsubj|mice mice|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17675505	0	CD4	18,21	IL-4	69,73	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reveal|nmod|cells reveal|nsubj|mice mice|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17709489	0	CD4	0,3	IL-4	33,37	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	deletion|compound|START_ENTITY deletion|nmod|alpha alpha|compound|END_ENTITY	CD4 + T cell-specific deletion of IL-4 receptor alpha prevents ovalbumin-induced anaphylaxis by an IFN-gamma-dependent mechanism .
17709492	0	CD4	81,84	IL-4	85,89	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD8 + T cell-mediated airway_hyperresponsiveness and inflammation is dependent on CD4 + IL-4 + T cells .
17883452	0	CD4	47,50	IL-4	127,131	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|dep|cells cells|acl|responding responding|xcomp|cognate cognate|advcl|develop develop|dobj|capacity capacity|acl|express express|dobj|END_ENTITY	Feeding by the tick , Ixodes_scapularis , causes CD4 -LRB- + -RRB- T cells responding to cognate antigen to develop the capacity to express IL-4 .
18453568	0	CD4	22,25	IL-4	43,47	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY CCR9|nmod|cells Imprinting|nmod|CCR9 requires|nsubj|Imprinting requires|dobj|END_ENTITY	Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells .
18591677	0	CD4	45,48	IL-4	74,78	CD4	IL-4	920	3565	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|acl|derived derived|nmod|precursors precursors|compound|END_ENTITY	Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors .
19003207	0	CD4	153,156	IL-4	103,107	CD4	IL-4	920	3565	Gene	Gene	Cells|compound|START_ENTITY Cultures|nmod|Cells Induce|nmod|Cultures Induce|dobj|Production Production|nmod|END_ENTITY	Dendritic Cells from Spleen , Mesenteric Lymph Node and Peyer 's Patch Can Induce the Production of Both IL-4 and IFN-gamma from Primary Cultures of Naive CD4 -LRB- + -RRB- T Cells in a Dose-Dependent Manner .
19036925	0	CD4	0,3	IL-4	118,122	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cell-secreted|nummod|START_ENTITY cytokine|nsubj|cell-secreted cytokine|ccomp|suppresses suppresses|advcl|inhibiting inhibiting|dobj|initiation initiation|nmod|production production|compound|END_ENTITY	CD4 cell-secreted , posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production .
1911543	0	CD4	48,51	IL-4	86,90	CD4	IL-4	920	3565	Gene	Gene	T|compound|START_ENTITY expressed|nmod|T expressed|dobj|clones clones|acl|cultured cultured|nmod|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
19493208	0	CD4	65,68	IL-4	88,92	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY host|dobj|cells host|xcomp|express express|dobj|END_ENTITY	SAAG-4 is a novel mosquito salivary protein that programmes host CD4 T cells to express IL-4 .
1968430	0	CD4	65,68	IL-4	45,49	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	populations|compound|START_ENTITY END_ENTITY|nmod|populations	Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4 + populations .
19781371	0	CD4	58,61	IL-4	124,128	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY receptors|nmod|T cells|amod|receptors Expression|nmod|cells Expression|acl|induced induced|nmod|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
20010912	0	CD4	55,58	IL-4	30,34	CD4	IL-4	920	3565	Gene	Gene	determination|compound|START_ENTITY signalling|nmod|determination requirements|parataxis|signalling requirements|nmod|END_ENTITY	Differential requirements for IL-4 / STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses .
20392496	0	CD4	18,21	IL-4	0,4	CD4	IL-4	920	3565	Gene	Gene	directs|dobj|START_ENTITY directs|nsubj|END_ENTITY	IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro , but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo .
20495070	0	CD4	74,77	IL-4	97,101	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY peptide|nmod|responses competition|nmod|peptide lack|nmod|competition unmasks|nsubj|lack unmasks|dobj|production production|compound|END_ENTITY	Cutting edge : lack of high affinity competition for peptide in polyclonal CD4 + responses unmasks IL-4 production .
20812238	0	CD4	53,56	IL-4	104,108	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY production|nmod|T modulate|iobj|production modulate|dobj|cells cells|nmod|IL-10 IL-10|nmod|production production|nmod|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20812238	0	CD4	6,9	IL-4	104,108	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|modulate modulate|dobj|cells cells|nmod|IL-10 IL-10|nmod|production production|nmod|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20869773	0	CD4	57,60	IL-4	18,22	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY nonresponsiveness|nmod|cells reverses|dobj|nonresponsiveness reverses|nsubj|Neutralization Neutralization|nmod|END_ENTITY	Neutralization of IL-4 reverses the nonresponsiveness of CD4 + T cells to regulatory T-cell induction in non-responder mouse strains .
20980261	0	CD4	68,71	IL-4	96,100	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY mediated|nsubjpass|cells mediated|nmod|END_ENTITY	Inhibition of suppressive T_cell_factor_1 -LRB- TCF-1 -RRB- isoforms in naive CD4 + T cells is mediated by IL-4 / STAT6 signaling .
2105169	0	CD4	22,25	IL-4	51,55	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY analysis|nmod|cells cloned|nsubj|analysis cloned|nmod|END_ENTITY	Frequency analysis of CD4 + CD8 + T cells cloned with IL-4 .
21282512	0	CD4	93,96	IL-4	29,33	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY regulated|nmod|cells regulated|nsubjpass|Induction Induction|nmod|expression expression|compound|END_ENTITY	Induction and maintenance of IL-4 expression are regulated differently by the 3 ' enhancer in CD4 T cells .
23545299	0	CD4	74,77	IL-4	60,64	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY induce|dobj|T induce|iobj|interleukin-4 interleukin-4|appos|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
23675066	0	CD4	68,71	IL-4	18,22	CD4	IL-4	920	3565	Gene	Gene	Foxp3|compound|START_ENTITY inducing|dobj|Foxp3 Neutralization|acl|inducing Neutralization|nmod|END_ENTITY	Neutralization of IL-4 and IFN-y Facilitates inducing TGF-b-induced CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory Cells .
23958647	0	CD4	57,60	IL-4	0,4	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells confers|nmod|suppression confers|nsubj|END_ENTITY	IL-4 confers resistance to IL-27-mediated suppression on CD4 + T cells by impairing signal_transducer_and_activator_of_transcription_1 signaling .
23997222	0	CD4	125,128	IL-4	15,19	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY receptor|nmod|cells expression|nmod|receptor induces|nmod|expression induces|dobj|secretion secretion|compound|END_ENTITY	HLA-G5 induces IL-4 secretion critical for successful pregnancy through differential expression of ILT2 receptor on decidual CD4 T cells and macrophages .
24089996	0	CD4	123,126	IL-4	155,159	CD4	IL-4	920	3565	Gene	Gene	T|compound|START_ENTITY T|dep|responses responses|nmod|production production|compound|END_ENTITY	The 30-kDa and 38-kDa antigens from Mycobacterium_tuberculosis induce partial maturation of human dendritic cells shifting CD4 -LRB- + -RRB- T cell responses towards IL-4 production .
24778440	0	CD4	0,3	IL-4	92,96	CD4	IL-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY poised|nsubjpass|cells poised|xcomp|run run|dobj|program program|compound|END_ENTITY	CD4 + T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program .
25108019	0	CD4	43,46	IL-4	59,63	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY prime|dobj|cells prime|nmod|production production|compound|END_ENTITY	Helminth-conditioned dendritic cells prime CD4 + T cells to IL-4 production in vivo .
25607842	0	CD4	18,21	IL-4	63,67	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|protect protect|dobj|neurons neurons|nmod|END_ENTITY	MHCII-independent CD4 + T cells protect injured CNS neurons via IL-4 .
2570801	0	CD4	77,80	IL-4	69,73	CD4	IL-4	920	3565	Gene	Gene	CD45R|compound|START_ENTITY END_ENTITY|nmod|CD45R	Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4 + CD29 + CD45R - memory T lymphocytes .
25938785	0	CD4	18,21	IL-4	63,67	CD4	IL-4	920	3565	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|protect protect|dobj|neurons neurons|nmod|END_ENTITY	MHCII-independent CD4 + T cells protect injured CNS neurons via IL-4 .
25999672	0	CD4	66,69	IL-4	14,18	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY characteristic|nmod|cells Intracellular|nmod|characteristic Intracellular|dobj|END_ENTITY	Intracellular IL-4 , IL-5 , and IFN-y as the main characteristic of CD4 + CD30 + T cells after allergen stimulation in patients with vernal_keratoconjunctivitis .
7530038	0	CD4	90,93	IL-4	32,36	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	response|compound|START_ENTITY profile|nmod|response establishment|dep|profile establishment|nmod|END_ENTITY	Rapid establishment of a stable IL-4 / IFN-gamma production profile in the antigen-specific CD4 + T cell response to protein immunization .
7586698	0	CD4	61,64	IL-4	51,55	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|nmod|END_ENTITY	Spontaneous production of various cytokines except IL-4 from CD4 + T cells in the affected organs of sarcoidosis patients .
7602091	0	CD4	75,78	IL-4	33,37	CD4	IL-4	920	3565	Gene	Gene	lymphocytes|compound|START_ENTITY inhibits|nmod|lymphocytes inhibits|dobj|production production|nmod|END_ENTITY	IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4 + T lymphocytes .
7808764	0	CD4	87,90	IL-4	140,144	CD4	IL-4	24932(Tax:10116)	287287(Tax:10116)	Gene	Gene	OX22|compound|START_ENTITY OX22|dep|secretion secretion|nmod|END_ENTITY	Cytokine profile of protective anti-Trichinella_spiralis CD4 + OX22 - and non-protective CD4 + OX22 + thoracic duct cells in rats : secretion of IL-4 alone does not determine protective capacity .
7819141	0	CD4	58,61	IL-4	18,22	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	cAMP up-regulates IL-4 and IL-5 production from activated CD4 + T cells while decreasing IL-2 release and NF-AT induction .
7876534	0	CD4	66,69	IL-4	15,19	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY synthesis|nmod|cells synthesis|compound|END_ENTITY	IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4 + T cells through an effect on antigen-presenting cells .
7902131	0	CD4	64,67	IL-4	19,23	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY lost|nmod|cells lost|nsubjpass|sensitivity sensitivity|nmod|production production|compound|END_ENTITY	The sensitivity of IL-4 production for cAMP inducers is lost in CD4 + T cells from aged mice .
7911751	0	CD4	94,97	IL-4	62,66	CD4	IL-4	920	3565	Gene	Gene	differentiation|compound|START_ENTITY feature|nmod|differentiation production|nmod|feature production|compound|END_ENTITY	Age-related increase in the fraction of CD27-CD4 + T cells and IL-4 production as a feature of CD4 + T cell differentiation in vivo .
7912705	0	CD4	70,73	IL-4	123,127	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	subsets|compound|START_ENTITY subsets|acl:relcl|differ differ|nmod|production production|compound|END_ENTITY	Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production .
8327860	0	CD4	36,39	IL-4	97,101	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY numbers|nmod|cells transfer|nmod|numbers transfer|acl|treated treated|nmod|receptor receptor|compound|END_ENTITY	Adoptive transfer of low numbers of CD4 + T cells into SCID mice chronically treated with soluble IL-4 receptor does not prevent engraftment of IL-4-producing T cells .
8580071	0	CD4	15,18	IL-4	0,4	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	lymphocytes|nummod|START_ENTITY producing|dobj|lymphocytes END_ENTITY|acl|producing	IL-4 producing CD4 + TCR alpha beta int liver lymphocytes : influence of thymus , beta_2-microglobulin and NK1 .1 expression .
8613355	0	CD4	123,126	IL-4	36,40	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ associated|nsubjpass|cells reveals|ccomp|associated reveals|nsubj|immunization immunization|nmod|interleukin-4 interleukin-4|appos|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8617933	0	CD4	42,45	IL-4	112,116	CD4	IL-4	920	3565	Gene	Gene	lymphocytes|compound|START_ENTITY CD40_ligand|nmod|lymphocytes Cross-linking|nmod|CD40_ligand generates|nsubj|Cross-linking generates|ccomp|signal signal|dobj|synthesis synthesis|compound|END_ENTITY	Cross-linking of the CD40_ligand on human CD4 + T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis .
8921430	0	CD4	109,112	IL-4	67,71	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY synthesis|nmod|lymphocytes END_ENTITY|nmod|synthesis	Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes .
8992977	0	CD4	131,134	IL-4	15,19	CD4	IL-4	920	3565	Gene	Gene	cells|amod|START_ENTITY phenotype|nmod|cells regulate|dobj|phenotype regulate|nsubj|END_ENTITY	T cell-derived IL-4 and dendritic cell-derived IL-12 regulate the lymphokine-producing phenotype of alloantigen-primed naive human CD4 T cells .
9120316	0	CD4	56,59	IL-4	14,18	CD4	IL-4	920	3565	Gene	Gene	+|compound|START_ENTITY Expression|nmod|+ Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of IL-4 and IL-5 mRNA and protein product by CD4 + and CD8 + T cells , eosinophils , and mast cells in bronchial biopsies obtained from atopic_and_nonatopic _ -LRB- intrinsic -RRB- _ asthmatics .
9126977	0	CD4	47,50	IL-4	71,75	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induce|dobj|cells induce|xcomp|produce produce|dobj|END_ENTITY	Antigen-specific B cells preferentially induce CD4 + T cells to produce IL-4 .
9200431	0	CD4	18,21	IL-4	0,4	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	IL-4 secretion by CD4 + NK1 + T cells induces monocyte_chemoattractant_protein-1 in early listeriosis .
9278312	0	CD4	16,19	IL-4	54,58	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|amounts amounts|nmod|END_ENTITY	Cultured NK1 .1 + CD4 + T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1 .
9341744	0	CD4	13,16	IL-4	49,53	CD4	IL-4	920	3565	Gene	Gene	T|compound|START_ENTITY Detection|nmod|T lymphocytes|nsubj|Detection lymphocytes|dobj|END_ENTITY	Detection of CD4 + CD45RO + T lymphocytes producing IL-4 in response to antigens on Plasmodium_falciparum erythrocytes : an in vitro correlate of protective immunity induced with attenuated Plasmodium_falciparum sporozoites .
9380721	0	CD4	48,51	IL-4	18,22	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY revealed|nsubjpass|production independent|ccomp|revealed mice|amod|independent interleukin_4|dep|mice interleukin_4|appos|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9380721	0	CD4	48,51	IL-4	60,64	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9380721	0	CD4	48,51	IL-4	91,95	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY revealed|nsubjpass|production revealed|nmod|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9438489	0	CD4	88,91	IL-4	29,33	CD4	IL-4	920	3565	Gene	Gene	+|compound|START_ENTITY induced|nmod|+ induced|nsubj|contribution contribution|nmod|END_ENTITY	The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4 + or CD8 + T cells .
9620597	0	CD4	45,48	IL-4	79,83	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY Development|nmod|lymphocytes requires|nsubj|Development requires|dobj|production production|compound|END_ENTITY	Development of hapten-induced IL-4-producing CD4 + T lymphocytes requires early IL-4 production by alphabeta T lymphocytes carrying invariant V -LRB- alpha -RRB- 14 TCR alpha chains .
9637480	0	CD4	79,82	IL-4	93,97	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY involved|nmod|cells involved|parataxis|have have|nsubj|END_ENTITY	Factors involved in the differentiation of TGF-beta-producing cells from naive CD4 + T cells : IL-4 and IFN-gamma have opposing effects , while TGF-beta positively regulates its own production .
9784657	0	CD4	60,63	IL-4	33,37	CD4	IL-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|dobj|production production|compound|END_ENTITY	Exogenous interleukin-3 enhances IL-4 production by splenic CD4 + cells during the early stages of a Trichinella_spiralis_infection .
9820484	0	CD4	100,103	IL-4	152,156	CD4	IL-4	24932(Tax:10116)	287287(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|dependent dependent|nmod|END_ENTITY	Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4 + suppressor T cells that are not dependent upon IL-4 .
21245915	0	CD4	25,28	IL-4Ra	36,42	CD4	IL-4Ra	12504(Tax:10090)	16190(Tax:10090)	Gene	Gene	Load|compound|START_ENTITY Load|compound|END_ENTITY	BALB/c mice deficient in CD4 T cell IL-4Ra expression control Leishmania mexicana Load although female but not male mice develop a healer phenotype .
23543769	0	CD4	10,13	IL-4Ra	0,6	CD4	IL-4Ra	12504(Tax:10090)	3566	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	IL-4Ra on CD4 + T cells plays a pathogenic role in respiratory_syncytial_virus reinfection in mice infected initially as neonates .
15816016	0	CD4	81,84	IL-4Ralpha	0,10	CD4	IL-4Ralpha	920	3566	Gene	Gene	help|compound|START_ENTITY absence|nmod|help important|nmod|absence important|nsubj|signaling signaling|compound|END_ENTITY	IL-4Ralpha signaling is important for CD8 + T cell cytotoxicity in the absence of CD4 + T cell help .
17500591	0	CD4	26,29	IL-4Ralpha	12,22	CD4	IL-4Ralpha	12504(Tax:10090)	16190(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania_major_infection .
10590258	0	CD4	0,3	IL-5	95,99	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|dobj|cells cells|acl|induced induced|xcomp|expressing expressing|ccomp|epitope epitope|dobj|production production|compound|END_ENTITY	CD4 -LRB- + -RRB- T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p_1 independently of IFN-gamma production .
10598017	0	CD4	24,27	IL-5	43,47	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY produce|nsubj|cells produce|xcomp|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
10598017	0	CD4	66,69	IL-5	43,47	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|advcl|produce produce|xcomp|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
11504693	0	CD4	54,57	IL-5	17,21	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY cells|amod|dependent cells|nsubj|AHR AHR|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Intrinsic AHR in IL-5 transgenic_mice is dependent on CD4 -LRB- + -RRB- cells and CD49d-mediated signaling .
11544451	0	CD4	84,87	IL-5	61,65	CD4	IL-5	920	3567	Gene	Gene	cells|compound|START_ENTITY promoter|nmod|cells promoter|amod|binding binding|nmod|END_ENTITY	Dexamethasone inhibits the binding of nuclear factors to the IL-5 promoter in human CD4 T cells .
11741821	0	CD4	52,55	IL-5	22,26	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY identifies|ccomp|T identifies|nsubj|expression expression|nmod|END_ENTITY	Ectopic expression of IL-5 identifies an additional CD4 -LRB- + -RRB- T cell mechanism of airway eosinophil recruitment .
11943672	0	CD4	0,3	IL-5	70,74	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|occurs occurs|nmod|expression expression|compound|END_ENTITY	CD4 -LRB- + -RRB- T cell-dependent airway mucus production occurs in response to IL-5 expression in lung .
1350983	0	CD4	60,63	IL-5	32,36	CD4	IL-5	920	3567	Gene	Gene	+|compound|START_ENTITY vitro|nmod|+ helper|amod|vitro production|nmod|helper production|compound|END_ENTITY	Aberrant interleukin -LRB- IL -RRB- -4 and IL-5 production in vitro by CD4 + helper T cells from atopic subjects .
15214040	0	CD4	0,3	IL-5	99,103	CD4	IL-5	920	3567	Gene	Gene	IL-2Ralpha|amod|START_ENTITY IL-2Ralpha|acl:relcl|subset subset|acl:relcl|secrete secrete|xcomp|END_ENTITY	CD4 -LRB- - -RRB- c-kit -LRB- - -RRB- CD3epsilon -LRB- - -RRB- IL-2Ralpha -LRB- + -RRB- Peyer 's patch cells are a novel cell subset which secrete IL-5 in response to IL-2 : implications for their role in IgA production .
15947486	0	CD4	45,48	IL-5	18,22	CD4	IL-5	920	3567	Gene	Gene	cells|nummod|START_ENTITY transcription|nmod|cells transcription|nsubj|Role Role|nmod|GATA-3 GATA-3|nmod|gene gene|compound|END_ENTITY	Role of GATA-3 in IL-5 gene transcription by CD4 + T cells of asthmatic patients .
16364153	0	CD4	0,3	IL-5	30,34	CD4	IL-5	920	3567	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ perpetuate|nsubj|cells perpetuate|dobj|production production|compound|END_ENTITY	CD4 + CD30 + T cells perpetuate IL-5 production in Dermatophagoides_pteronyssinus allergic patients .
1967279	0	CD4	14,17	IL-5	80,84	CD4	IL-5	920	3567	Gene	Gene	+|compound|START_ENTITY produce|nsubj|+ produce|dobj|factor factor|compound|IFN-gamma IFN-gamma|compound|END_ENTITY	Host-reactive CD4 + and CD8 + T cell clones isolated from a human chimera produce IL-5 , IL-2 , IFN-gamma and granulocyte/macrophage-colony-stimulating _ factor but not IL-4 .
21215348	0	CD4	16,19	IL-5	0,4	CD4	IL-5	920	3567	Gene	Gene	lymphocytes|compound|START_ENTITY release|nmod|lymphocytes release|compound|END_ENTITY	IL-5 release of CD4 + non-effector lymphocytes is increased in COPD -- modulating effects of moxifloxacin and dexamethasone .
22310911	0	CD4	44,47	IL-5	0,4	CD4	IL-5	920	3567	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells promotes|dobj|induction promotes|nsubj|END_ENTITY	IL-5 promotes induction of antigen-specific CD4 + CD25 + T regulatory cells that suppress autoimmunity .
22627364	0	CD4	117,120	IL-5	82,86	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|acl|cells production|compound|END_ENTITY	Higher sensitivity of male CD4 + T cells to suppressive effects of CD8 + T cells on IL-5 production compared to female CD4 + T cells .
22627364	0	CD4	27,30	IL-5	82,86	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	sensitivity|nmod|START_ENTITY +|nsubj|sensitivity +|xcomp|suppressive suppressive|nmod|production production|compound|END_ENTITY	Higher sensitivity of male CD4 + T cells to suppressive effects of CD8 + T cells on IL-5 production compared to female CD4 + T cells .
26700766	0	CD4	53,56	IL-5	85,89	CD4	IL-5	920	3567	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	LZTFL1 Upregulated by All-trans_Retinoic_Acid during CD4 + T Cell Activation Enhances IL-5 Production .
7540862	0	CD4	19,22	IL-5	0,4	CD4	IL-5	920	3567	Gene	Gene	cells|nummod|START_ENTITY production|nmod|cells production|compound|END_ENTITY	IL-5 production by CD4 + T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin_A .
8658534	0	CD4	65,68	IL-5	35,39	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY superinduction|nmod|cells superinduction|compound|END_ENTITY	Vomitoxin-mediated IL-2 , IL-4 , and IL-5 superinduction in murine CD4 + T cells stimulated with phorbol ester calcium ionophore : relation to kinetics of proliferation .
8661368	0	CD4	65,68	IL-5	35,39	CD4	IL-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	Stimulated|compound|START_ENTITY Superinduction|nmod|Stimulated Superinduction|compound|END_ENTITY	Vomitoxin-Mediated IL-2 , IL-4 , and IL-5 Superinduction in Murine CD4 + T Cells Stimulated with Phorbol Ester and Calcium Ionophore : Relation to Kinetics of Proliferation The effects of the trichothecene vomitoxin -LRB- VT -RRB- on the kinetics of cell proliferation and cytokine production were evaluated in murine CD4 -LRB- + -RRB- T cells .
9111503	0	CD4	38,41	IL-5	0,4	CD4	IL-5	920	3567	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	IL-5 secretion by allergen-stimulated CD4 + T cells in primary culture : relationship to expression of allergic_disease .
9218830	0	CD4	18,21	IL-5	0,4	CD4	IL-5	920	3567	Gene	Gene	lymphocytes|compound|START_ENTITY expressed|nmod|lymphocytes expressed|nsubj|END_ENTITY	IL-5 expressed by CD4 + lymphocytes from Echinococcus_multilocularis-infected patients .
15100309	0	CD4	71,74	IL-6	0,4	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	manners|compound|START_ENTITY prevents|nmod|manners prevents|nsubj|END_ENTITY	IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4 + T cell - and STAT3-dependent manners .
15728480	0	CD4	78,81	IL-6	0,4	CD4	IL-6	920	3569	Gene	Gene	activation|compound|START_ENTITY stage|nmod|activation initiating|nmod|stage plays|advcl|initiating plays|nsubj|END_ENTITY	IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation .
15935883	0	CD4	101,104	IL-6	0,4	CD4	IL-6	920	3569	Gene	Gene	cells|compound|START_ENTITY effect|nmod|cells regulating|dobj|effect controls|advcl|regulating controls|nsubj|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
17182564	0	CD4	64,67	IL-6	0,4	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY functions|nsubj|cell inhibits|xcomp|functions inhibits|nsubj|END_ENTITY	IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4 + CD25 + T cell regulatory functions .
17981790	0	CD4	44,47	IL-6	12,16	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	colitis|compound|START_ENTITY prevents|dobj|colitis prevents|nsubj|Blocking Blocking|nmod|END_ENTITY	Blocking of IL-6 signaling pathway prevents CD4 + T cell-mediated colitis in a T -LRB- h -RRB- 17-independent manner .
18490709	0	CD4	20,23	IL-6	114,118	CD4	IL-6	920	3569	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|resistant resistant|nmod|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18845487	0	CD4	23,26	IL-6	15,19	CD4	IL-6	920	3569	Gene	Gene	responses|compound|START_ENTITY effects|nmod|responses effects|nmod|END_ENTITY	The effects of IL-6 on CD4 T cell responses .
19050105	0	CD4	99,102	IL-6	50,54	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	death|compound|START_ENTITY involved|nmod|death involved|nsubjpass|expression expression|nmod|cells cells|acl|regulated regulated|nmod|signal signal|compound|END_ENTITY	IFN-gamma expression in CD8 + T cells regulated by IL-6 signal is involved in superantigen-mediated CD4 + T cell death .
19139170	0	CD4	89,92	IL-6	40,44	CD4	IL-6	920	3569	Gene	Gene	cells|compound|START_ENTITY produced|nmod|cells IL-21|acl|produced mediated|nmod|IL-21 mediated|nsubjpass|induction induction|nmod|production production|nmod|END_ENTITY	The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4 + T cells .
19181387	0	CD4	28,31	IL-6	9,13	CD4	IL-6	920	3569	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Elevated IL-6 expression in CD4 T cells via PKCtheta and NF-kappaB induces Th2 cytokine production .
20083667	0	CD4	8,11	IL-6	79,83	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Loss|nmod|expression underlines|nsubj|Loss underlines|dobj|role role|nmod|trans trans|compound|END_ENTITY	Loss of CD4 + T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells .
20519164	0	CD4	45,48	IL-6	118,122	CD4	IL-6	920	3569	Gene	Gene	lymphocytes|compound|START_ENTITY profiling|nmod|lymphocytes reveals|nsubj|profiling reveals|dobj|Th-subpopulation Th-subpopulation|acl|characterized characterized|nmod|END_ENTITY	Cytokine profiling of human peripheral blood CD4 + T lymphocytes reveals a new Th-subpopulation -LRB- Th6 -RRB- characterized by IL-6 .
21048114	0	CD4	21,24	IL-6	142,146	CD4	IL-6	920	3569	Gene	Gene	Enrichment|nmod|START_ENTITY cells|dep|Enrichment _|dep|cells _|nmod|END_ENTITY	Enrichment of Foxp3 + CD4 regulatory T cells in migrated_T cells to IL-6 - _ and_IL-8-expressing tumors through predominant induction of CXCR1 by IL-6 .
21944889	0	CD4	7,10	IL-6	52,56	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|xcomp|END_ENTITY	Na ve CD4 + T cells of Peyer 's patches produce more IL-6 than those of spleen in response to antigenic stimulation .
22025555	0	CD4	50,53	IL-6	0,4	CD4	IL-6	920	3569	Gene	Gene	cells|compound|START_ENTITY mediated|nmod|cells rejection|acl|mediated promotes|dobj|rejection promotes|nsubj|END_ENTITY	IL-6 promotes cardiac graft rejection mediated by CD4 + cells .
22084439	0	CD4	93,96	IL-6	13,17	CD4	IL-6	920	3569	Gene	Gene	cells|compound|START_ENTITY emergence|nmod|cells allowing|dobj|emergence reduces|advcl|allowing reduces|nsubj|END_ENTITY	Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161 + CD4 + regulatory T cells .
22424785	0	CD4	0,3	IL-6	99,103	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY function|nsubj|cells function|nmod|deletion deletion|nmod|END_ENTITY	CD4 + Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene .
22491065	0	CD4	40,43	IL-6	0,4	CD4	IL-6	920	3569	Gene	Gene	cells|compound|START_ENTITY triggers|nmod|cells triggers|nsubj|END_ENTITY	IL-6 triggers IL-21 production by human CD4 + T cells to drive STAT3-dependent plasma cell differentiation in B cells .
24379058	0	CD4	113,116	IL-6	12,16	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	population|compound|START_ENTITY producing|nmod|population IL-17|acl|producing acute_inflammatory_bowel_disease|nmod|IL-17 exacerbates|dobj|acute_inflammatory_bowel_disease exacerbates|nsubj|Blockade Blockade|nmod|signal signal|compound|END_ENTITY	Blockade of IL-6 signal exacerbates acute_inflammatory_bowel_disease via inhibiting IL-17 producing in activated CD4 + Th17 population .
24681564	0	CD4	61,64	IL-6	123,127	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	T|compound|START_ENTITY differentiation|nmod|T cells|compound|differentiation limits|dobj|cells limits|advcl|antagonizing antagonizing|advcl|signaling signaling|nmod|receptor receptor|nmod|END_ENTITY	The adaptor TRAF5 limits the differentiation of inflammatory CD4 -LRB- + -RRB- T cells by antagonizing signaling via the receptor for IL-6 .
24690994	0	CD4	69,72	IL-6	10,14	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	+25|compound|START_ENTITY Foxp3|nummod|+25 counteracting|dobj|Foxp3 enhances|advcl|counteracting enhances|nsubj|END_ENTITY	Transgene IL-6 enhances DC-stimulated CTL responses by counteracting CD4 +25 + Foxp3 + regulatory T cell suppression via IL-6-induced Foxp3 downregulation .
25100658	0	CD4	6,9	IL-6	126,130	CD4	IL-6	920	3569	Gene	Gene	cells|compound|START_ENTITY trigger|nsubj|cells trigger|xcomp|requiring requiring|dobj|END_ENTITY	Donor CD4 T cells trigger costimulation blockade-resistant donor bone marrow rejection through bystander activation requiring IL-6 .
25797206	0	CD4	19,22	IL-6	52,56	CD4	IL-6	920	3569	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|increased increased|dobj|production production|compound|END_ENTITY	Preterm cord blood CD4 -LRB- + -RRB- T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4 -LRB- + -RRB- T cells in bronchopulmonary_dysplasia .
26759006	0	CD4	131,134	IL-6	0,4	CD4	IL-6	920	3569	Gene	Gene	T|compound|START_ENTITY activation|nmod|T cells|compound|activation impair|dobj|cells down-regulates|xcomp|impair down-regulates|nsubj|END_ENTITY	IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4 -LRB- + -RRB- T cells .
7907103	0	CD4	61,64	IL-6	8,12	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY signaling|nmod|responses Role|acl|signaling Role|nmod|END_ENTITY	Role of IL-6 , IL-1 , and CD28 signaling in responses of mouse CD4 + T cells to immobilized anti-TCR monoclonal antibody .
8613355	0	CD4	123,126	IL-6	148,152	CD4	IL-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|acl|producing producing|xcomp|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
9472657	0	CD4	126,129	IL-6	12,16	CD4	IL-6	920	3569	Gene	Gene	cells|nummod|START_ENTITY associated|nmod|cells END_ENTITY|parataxis|associated	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9472657	0	CD4	40,43	IL-6	12,16	CD4	IL-6	920	3569	Gene	Gene	cells|nummod|START_ENTITY dysregulation|nmod|cells associated|nsubjpass|dysregulation END_ENTITY|parataxis|associated	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9485207	0	CD4	44,47	IL-6	61,65	CD4	IL-6	920	3569	Gene	Gene	responses|nummod|START_ENTITY effector|dobj|responses effector|nmod|END_ENTITY	Augmentation of naive , Th1 and Th2 effector CD4 responses by IL-6 , IL-1_and_TNF .
17496315	0	CD4	47,50	IL-6R	18,23	CD4	IL-6R	12504(Tax:10090)	16194(Tax:10090)	Gene	Gene	apoptosis|compound|START_ENTITY induces|dobj|apoptosis induces|nsubj|blockade blockade|nmod|signaling signaling|compound|END_ENTITY	Local blockade of IL-6R signaling induces lung CD4 + T cell apoptosis in a murine model of asthma via regulatory T cells .
17675459	0	CD4	94,97	IL-6R	46,51	CD4	IL-6R	12504(Tax:10090)	16194(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY FoxP3|nmod|cells induction|nmod|FoxP3 abrogates|dobj|induction abrogates|nsubj|trans-signaling trans-signaling|nmod|END_ENTITY	Cutting edge : trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4 + CD25 T cells .
18490707	0	CD4	82,85	IL-6R	22,27	CD4	IL-6R	920	3570	Gene	Gene	cells|compound|START_ENTITY shedding|nmod|cells ectodomain|acl|shedding produced|nmod|ectodomain produced|nsubjpass|END_ENTITY	Cutting edge : soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells .
18490707	0	CD4	82,85	IL-6R	43,48	CD4	IL-6R	920	3570	Gene	Gene	cells|compound|START_ENTITY shedding|nmod|cells ectodomain|acl|shedding ectodomain|compound|END_ENTITY	Cutting edge : soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells .
20019339	0	CD4	88,91	IL-6R	68,73	CD4	IL-6R	920	3570	Gene	Gene	Cells|compound|START_ENTITY expression|nmod|Cells expression|compound|END_ENTITY	Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4 + T Cells .
20083667	0	CD4	8,11	IL-6R	20,25	CD4	IL-6R	12504(Tax:10090)	16194(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Loss of CD4 + T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells .
15922716	0	CD4	96,99	IL-7	11,15	CD4	IL-7	920	3574	Gene	Gene	cells|compound|START_ENTITY Effects|nmod|cells Effects|nmod|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
19008454	0	CD4	45,48	IL-7	0,4	CD4	IL-7	920	3574	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells sustains|dobj|expression sustains|nsubj|END_ENTITY	IL-7 sustains CD31 expression in human naive CD4 + T cells and preferentially expands the CD31 + subset in a PI3K-dependent manner .
21673554	0	CD4	38,41	IL-7	32,36	CD4	IL-7	920	3574	Gene	Gene	cells|compound|START_ENTITY proliferate|nsubj|cells proliferate|nmod|response response|nmod|END_ENTITY	Despite an impaired response to IL-7 , CD4 + EM T cells from HIV-positive patients proliferate normally in response to IL-15 and its superagonist , RLI .
18566388	0	CD4	25,28	IL-7R	15,20	CD4	IL-7R	12504(Tax:10090)	16197(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
20623548	0	CD4	62,65	IL-7R_alpha	67,78	CD4	IL-7R alpha	12504(Tax:10090)	16197(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 is positively involved in the development of colitogenic CD4 + IL-7R_alpha high memory T cells in chronic_colitis .
12148887	0	CD4	31,34	IL-8	12,16	CD4	IL-8	920	3576	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Spontaneous IL-8 production by CD4 -LRB- + -RRB- , CD7 -LRB- + -RRB- leukemia cells in erythrodermic_S __ zary_syndrome .
22031506	0	CD4	54,57	IL-8	86,90	CD4	IL-8	920	3576	Gene	Gene	activity|compound|START_ENTITY activity|nmod|promoter promoter|compound|END_ENTITY	Native X-DING-CD4 protein secreted by HIV-1 resistant CD4 + T cells blocks activity of IL-8 promoter in human endothelial cells infected with enteric bacteria .
24692846	0	CD4	38,41	IL-8	14,18	CD4	IL-8	920	3576	Gene	Gene	cells|compound|START_ENTITY producing|dobj|cells Generation|acl|producing Generation|nmod|END_ENTITY	Generation of IL-8 and IL-9 producing CD4 T cells is affected by Th17 polarizing conditions and AHR ligands .
8576572	0	CD4	66,69	IL-8	14,18	CD4	IL-8	920	3576	Gene	Gene	+|compound|START_ENTITY selected|dobj|+ selected|nsubj|Production Production|nmod|END_ENTITY	Production of IL-8 and IL-4 by positively and negatively selected CD4 + and CD8 + human T cells following a four-step cell separation method including magnetic cell sorting -LRB- MACS -RRB- .
8604020	0	CD4	85,88	IL-8	0,4	CD4	IL-8	920	3576	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	IL-8 induces T cell chemotaxis , suppresses IL-4 , and up-regulates IL-8 production by CD4 + T cells .
20020328	0	CD4	43,46	IL-9	0,4	CD4	IL-9	920	3578	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	IL-9 : basic biology , signaling pathways in CD4 + T cells and implications for autoimmunity .
20090929	0	CD4	36,39	IL-9	40,44	CD4	IL-9	920	3578	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Human CD4 memory T cells can become CD4 + IL-9 + T cells .
20090929	0	CD4	6,9	IL-9	40,44	CD4	IL-9	920	3578	Gene	Gene	cells|compound|START_ENTITY become|nsubj|cells become|xcomp|cells cells|compound|END_ENTITY	Human CD4 memory T cells can become CD4 + IL-9 + T cells .
20540113	0	CD4	94,97	IL-9	69,73	CD4	IL-9	12504(Tax:10090)	16198(Tax:10090)	Gene	Gene	T|compound|START_ENTITY trigger|nmod|T trigger|dobj|production production|amod|END_ENTITY	TGF-b interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4 -LRB- + -RRB- T cells .
26322481	0	CD4	59,62	IL-9	40,44	CD4	IL-9	920	3578	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|compound|END_ENTITY	The DNA-binding inhibitor Id3 regulates IL-9 production in CD4 -LRB- + -RRB- T cells .
27094152	0	CD4	73,76	IL-9	0,4	CD4	IL-9	920	3578	Gene	Gene	CD8|compound|START_ENTITY survival|dep|CD8 promotes|dobj|survival promotes|nsubj|END_ENTITY	IL-9 promotes the survival and function of human melanoma - infiltrating CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- double-positive T cells .
7930607	0	CD4	25,28	IL-9	0,4	CD4	IL-9	12504(Tax:10090)	16198(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	IL-9 production of naive CD4 + T cells depends on IL-2 , is synergistically enhanced by a combination of TGF-beta and IL-4 , and is inhibited by IFN-gamma .
11340333	0	CD4	0,3	IL13	4,8	CD4	IL13	920	3596	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + IL13 + T lymphocytes at birth and the development of wheezing and/or asthma during the 1st year of life .
19277040	0	CD4	54,57	IL17A	58,63	CD4	IL17A	920	3605	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
16809611	0	CD4	64,67	IL2	41,44	CD4	IL2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|compound|END_ENTITY	BCL11B participates in the activation of IL2 gene expression in CD4 + T lymphocytes .
22371423	0	CD4	50,53	IL2	21,24	CD4	IL2	920	3558	Gene	Gene	+|compound|START_ENTITY helper|nummod|+ interplay|nmod|helper Modeling|nmod|interplay Modeling|dobj|role role|nmod|END_ENTITY	Modeling the role of IL2 in the interplay between CD4 + helper and regulatory T cells : studying the impact of IL2 modulation therapies .
22182694	0	CD4	139,142	IL23R	132,137	CD4	IL23R	920	149233	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Preliminary study : treatment with intramuscular interferon beta-1a results in increased levels of IL-12Rb2 + and decreased levels of IL23R + CD4 + T - Lymphocytes in multiple_sclerosis .
19380824	0	CD4	57,60	IRAK-1	79,85	CD4	IRAK-1	12504(Tax:10090)	16179(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY regulation|nmod|cells regulation|nmod|END_ENTITY	Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1 .
21919915	0	CD4	41,44	IRF4	24,28	CD4	IRF4	920	3662	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of IRF4 and ETS1 in CD4 + cells from patients with intermittent_allergic_rhinitis .
17947638	0	CD4	54,57	Ifng	27,31	CD4	Ifng	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY promoter|nmod|cells promoter|compound|END_ENTITY	Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigen .
19570000	0	CD4	61,64	IgG1	45,49	CD4	IgG1	12504(Tax:10090)	16017(Tax:10090)	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Subcutaneous bioavailability of a PRIMATIZED IgG1 anti-human CD4 monoclonal antibody is dose dependent in transgenic_mice bearing human CD4 .
19265114	0	CD4	128,131	Il-10	90,95	CD4	Il-10	920	3586	Gene	Gene	cells|compound|START_ENTITY induce|nmod|cells induce|dobj|production production|nmod|END_ENTITY	Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10 , IFN-gamma , and IL-17A by naive CD4 + T cells .
18511701	0	CD4	65,68	Interferon-gamma	0,16	CD4	Interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|regulates regulates|nsubj|END_ENTITY	Interferon-gamma regulates idiopathic_pneumonia_syndrome , a Th17 + CD4 + T-cell-mediated graft-versus-host_disease .
11529935	0	CD4	80,83	Interleukin-10	0,14	CD4	Interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	T-regulatory|compound|START_ENTITY generation|nmod|T-regulatory induces|dobj|generation expressed|dep|induces expressed|advmod|END_ENTITY	Interleukin-10 expressed at early_tumour sites induces subsequent generation of CD4 -LRB- + -RRB- T-regulatory cells and systemic collapse of antitumour immunity .
21817097	0	CD4	27,30	Interleukin-10	0,14	CD4	Interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY released|nmod|CD25 released|advmod|END_ENTITY	Interleukin-10 released by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice .
7510582	0	CD4	37,40	Interleukin-10	0,14	CD4	Interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Interleukin-10 production by splenic CD4 + cells and cell subsets from young and old mice .
8691133	0	CD4	75,78	Interleukin-10	0,14	CD4	Interleukin-10	920	3586	Gene	Gene	cells|compound|START_ENTITY state|nmod|cells induces|dobj|state induces|nsubj|END_ENTITY	Interleukin-10 induces a long-term antigen-specific anergic state in human CD4 + T cells .
8840221	0	CD4	107,110	Interleukin-10	0,14	CD4	Interleukin-10	920	3586	Gene	Gene	T|compound|START_ENTITY secretion|dep|T secretion|amod|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- secretion in systemic_lupus_erythematosus and rheumatoid_arthritis : IL-10-dependent CD4 + CD45RO + T cell-B cell antibody synthesis .
9825821	0	CD4	44,47	Interleukin-10	0,14	CD4	Interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	+|compound|START_ENTITY regulation|nmod|+ regulation|amod|END_ENTITY	Interleukin-10 dose-dependent regulation of CD4 + and CD8 + T cell-mediated graft-versus-host_disease .
10720515	0	CD4	100,103	Interleukin-2	0,13	CD4	Interleukin-2	920	3558	Gene	Gene	+|compound|START_ENTITY CCR5|nmod|+ expression|nmod|CCR5 expression|amod|END_ENTITY	Interleukin-2 up-regulates expression of the human_immunodeficiency_virus fusion coreceptor CCR5 by CD4 + lymphocytes in vivo .
12370501	0	CD4	26,29	Interleukin-2	0,13	CD4	Interleukin-2	920	3558	Gene	Gene	reconstitution|compound|START_ENTITY accelerates|dobj|reconstitution accelerates|nsubj|END_ENTITY	Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy : the ILSTIM study -- ANRS 082 .
15075538	0	CD4	60,63	Interleukin-2	0,13	CD4	Interleukin-2	920	3558	Gene	Gene	dynamics|compound|START_ENTITY effect|nmod|dynamics exerts|dobj|effect exerts|nsubj|END_ENTITY	Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamics .
15307180	0	CD4	31,34	Interleukin-2	0,13	CD4	Interleukin-2	920	3558	Gene	Gene	function|compound|START_ENTITY essential|nmod|function essential|nsubj|END_ENTITY	Interleukin-2 is essential for CD4 + CD25 + regulatory T cell function .
17312008	0	CD4	23,26	Interleukin-2	0,13	CD4	Interleukin-2	920	3558	Gene	Gene	memory|compound|START_ENTITY enhances|dobj|memory enhances|nsubj|END_ENTITY	Interleukin-2 enhances CD4 + T cell memory by promoting the generation of IL-7R_alpha-expressing cells .
17671219	0	CD4	40,43	Interleukin-2	0,13	CD4	Interleukin-2	920	3558	Gene	Gene	pool|compound|START_ENTITY alters|dobj|pool alters|nsubj|administration administration|amod|END_ENTITY	Interleukin-2 administration alters the CD4 + FOXP3 + T-cell pool and tumor trafficking in patients with ovarian_carcinoma .
18702891	0	CD4	90,93	Interleukin-2	0,13	CD4	Interleukin-2	920	3558	Gene	Gene	T_lymphocytopenia|compound|START_ENTITY child|nmod|T_lymphocytopenia treatment|nmod|child treatment|amod|END_ENTITY	Interleukin-2 treatment for persistent cryptococcal_meningitis in a child with idiopathic CD4 -LRB- + -RRB- T_lymphocytopenia .
24416451	0	CD4	42,45	Interleukin-2	91,104	CD4	Interleukin-2	920	3558	Gene	Gene	survival|compound|START_ENTITY survival|acl|priming priming|nmod|conditions conditions|compound|END_ENTITY	Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions .
25119341	0	CD4	122,125	Interleukin-2	70,83	CD4	Interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	help|compound|START_ENTITY independent|nmod|help independent|nsubj|activation activation|nmod|cells cells|nmod|END_ENTITY	Bystander activation and anti-tumor effects of CD8 + T cells following Interleukin-2 based immunotherapy is independent of CD4 + T cell help .
25485946	0	CD4	30,33	Interleukin-2	68,81	CD4	Interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Reactivity Reactivity|nmod|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
7868930	0	CD4	1,4	Interleukin-2	98,111	CD4	Interleukin-2	920	3558	Gene	Gene	TIL|compound|START_ENTITY induce|nsubj|TIL induce|nmod|patients patients|acl|treated treated|nmod|IL-2 IL-2|appos|END_ENTITY	-LSB- CD4 TIL -LRB- Tumor_Infiltrating_Lymphocytes -RRB- induce complete response in patients treated with IL-2 -LRB- Interleukin-2 -RRB- .
7909457	0	CD4	71,74	Interleukin-2	0,13	CD4	Interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ activity|nmod|cells inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits graft-versus-host_disease-promoting activity of CD4 + cells while preserving CD4 - and CD8-mediated graft-versus-leukemia effects .
7909457	0	CD4	99,102	Interleukin-2	0,13	CD4	Interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	effects|amod|START_ENTITY preserving|dobj|effects inhibits|advcl|preserving inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits graft-versus-host_disease-promoting activity of CD4 + cells while preserving CD4 - and CD8-mediated graft-versus-leukemia effects .
18190607	0	CD4	87,90	Interleukin-21	0,14	CD4	Interleukin-21	12504(Tax:10090)	60505(Tax:10090)	Gene	Gene	proliferation|compound|START_ENTITY activity|nmod|proliferation uptake|dobj|activity uptake|nsubj|antigen antigen|amod|END_ENTITY	Interleukin-21 stimulates antigen uptake , protease activity , survival and induction of CD4 + T cell proliferation by murine macrophages .
21227406	0	CD4	105,108	Interleukin-21	0,14	CD4	Interleukin-21	920	59067	Gene	Gene	T|compound|START_ENTITY IL-10|nmod|T cells|amod|IL-10 production|nmod|cells monocytes|nmod|production maintains|nmod|monocytes maintains|nsubj|END_ENTITY	Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human na ve CD4 + T cells .
24416451	0	CD4	42,45	Interleukin-21	0,14	CD4	Interleukin-21	920	59067	Gene	Gene	survival|compound|START_ENTITY regulator|nmod|survival regulator|nsubj|END_ENTITY	Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions .
19191911	0	CD4	92,95	Interleukin-4	0,13	CD4	Interleukin-4	920	3565	Gene	Gene	cells|compound|START_ENTITY adaptive|dobj|cells suppresses|dep|adaptive suppresses|nsubj|END_ENTITY	Interleukin-4 suppresses the cytotoxic potential of in vitro generated , adaptive regulatory CD4 T cells by down-regulation of granzyme_B .
24139939	1	CD4	124,127	Interleukin-4	71,84	CD4	Interleukin-4	24932(Tax:10116)	287287(Tax:10116)	Gene	Gene	CD25|compound|START_ENTITY maintain|dobj|CD25 maintain|nsubj|END_ENTITY	Interleukin-4 does not maintain alloantigen specific CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Treg .
3262830	0	CD4	46,49	Interleukin-4	0,13	CD4	Interleukin-4	920	3565	Gene	Gene	clones|compound|START_ENTITY induction|nmod|clones mediates|dobj|induction mediates|nsubj|END_ENTITY	Interleukin-4 mediates CD8 induction on human CD4 + T-cell clones .
23940537	0	CD4	119,122	Interleukin-5	0,13	CD4	Interleukin-5	920	3567	Gene	Gene	T|compound|START_ENTITY apoptosis|nmod|T cells|compound|apoptosis induce|dobj|cells expansion|acl:relcl|induce supports|dobj|expansion supports|nsubj|END_ENTITY	Interleukin-5 supports the expansion of fas_ligand-expressing killer B cells that induce antigen-specific apoptosis of CD4 -LRB- + -RRB- T cells and secrete interleukin-10 .
8648029	0	CD4	59,62	Interleukin-5	0,13	CD4	Interleukin-5	920	3567	Gene	Gene	cells|compound|START_ENTITY RNA|nmod|cells RNA|nsubj|messenger messenger|amod|END_ENTITY	Interleukin-5 messenger RNA expression in peripheral blood CD4 + cells in asthma .
18389078	0	CD4	65,68	Interleukin-6	0,13	CD4	Interleukin-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	T|compound|START_ENTITY recall|nmod|T crucial|nmod|recall cells|amod|crucial cells|nsubj|END_ENTITY	Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells .
11581400	0	CD4	40,43	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	depletion|compound|START_ENTITY correlates|nmod|depletion correlates|nsubj|END_ENTITY	Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human_immunodeficiency_virus_type_1-positive individuals .
15720434	0	CD4	86,89	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	naive|advmod|START_ENTITY cells|amod|naive sufficient|nmod|cells sufficient|nsubj|signalling signalling|amod|END_ENTITY	Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells .
16380489	0	CD4	39,42	Interleukin-7	0,13	CD4	Interleukin-7	12504(Tax:10090)	16196(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY factor|nmod|T-cells factor|nsubj|END_ENTITY	Interleukin-7 is a survival factor for CD4 + CD25 + T-cells and is expressed by diabetes-suppressive_dendritic_cells .
17855550	0	CD4	88,91	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	cells|nummod|START_ENTITY ve|dobj|cells enhances|advcl|ve enhances|nsubj|END_ENTITY	Interleukin-7 enhances proliferation responses to T-cell receptor stimulation in na ve CD4 + T cells from human_immunodeficiency_virus-infected persons .
20167604	0	CD4	75,78	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	response|compound|START_ENTITY initiate|dobj|response complex|xcomp|initiate signaling|xcomp|complex compartmentalizes|xcomp|signaling compartmentalizes|nsubj|END_ENTITY	Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response .
20465565	0	CD4	45,48	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	survival|nmod|START_ENTITY promotes|dobj|survival promotes|nsubj|END_ENTITY	Interleukin-7 promotes the survival of human CD4 + effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway .
22586481	0	CD4	31,34	Interleukin-7	0,13	CD4	Interleukin-7	12504(Tax:10090)	16196(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nsubj|+ influences|xcomp|cells influences|nsubj|END_ENTITY	Interleukin-7 influences FOXP3 + CD4 + regulatory T cells peripheral homeostasis .
23215679	0	CD4	64,67	Interleukin-7	0,13	CD4	Interleukin-7	12504(Tax:10090)	16196(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY survival|nmod|CD8 thymocytes|nsubj|survival supports|xcomp|thymocytes supports|nsubj|END_ENTITY	Interleukin-7 supports survival of T-cell_receptor-b-expressing CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- double-negative thymocytes .
26319414	0	CD4	30,33	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	T|compound|START_ENTITY required|nmod|T required|nsubjpass|END_ENTITY	Interleukin-7 is required for CD4 -LRB- + -RRB- T cell activation and autoimmune_neuroinflammation .
26965634	0	CD4	66,69	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	stage|compound|START_ENTITY development|nmod|stage promotes|dobj|development promotes|nsubj|END_ENTITY	Interleukin-7 promotes human regulatory T cell development at the CD4 + CD8 + double-positive thymocyte stage .
9079802	0	CD4	36,39	Interleukin-7	0,13	CD4	Interleukin-7	920	3574	Gene	Gene	cells|compound|START_ENTITY activates|dobj|cells activates|nsubj|END_ENTITY	Interleukin-7 activates human naive CD4 + cells and primes for interleukin-4 production .
10510091	0	CD4	107,110	Interleukin_2	0,13	CD4	Interleukin 2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generation|nmod|cells defect|nmod|generation reverse|dobj|defect reverse|nsubj|END_ENTITY	Interleukin_2 , but not other common gamma chain-binding cytokines , can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice .
12235217	0	CD4	40,43	Interleukin_2	0,13	CD4	Interleukin 2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	function|amod|START_ENTITY required|nmod|function required|nsubjpass|signaling signaling|compound|END_ENTITY	Interleukin_2 signaling is required for CD4 -LRB- + -RRB- regulatory T cell function .
25629163	0	CD4	104,107	Interleukin_2	73,86	CD4	Interleukin 2	920	3558	Gene	Gene	Cells|compound|START_ENTITY Transcription|nmod|Cells Transcription|compound|END_ENTITY	Inhibition of G-Protein by Signaling Enhances T Cell Receptor-Stimulated Interleukin_2 Transcription in CD4 + T Helper Cells .
2575597	0	CD4	51,54	Interleukin_2	0,13	CD4	Interleukin 2	920	3558	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|amod|END_ENTITY	Interleukin_2 production by alloantigen-stimulated CD4 + and CD8 + human T cell subsets : frequency of HLA class I or class II-reactive precursor cells and clonal specificity of activated T cells .
7479922	0	CD4	102,105	Interleukin_2	0,13	CD4	Interleukin 2	920	3558	Gene	Gene	cells|compound|START_ENTITY replication|nmod|cells suppression|nmod|replication induces|dobj|suppression induces|nsubj|END_ENTITY	Interleukin_2 induces CD8 + T cell-mediated suppression of human immunodeficiency virus replication in CD4 + T cells and this effect overrides its ability to stimulate virus expression .
1826374	0	CD4	62,65	Interleukin_4	0,13	CD4	Interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|compound|END_ENTITY	Interleukin_4 and interferon_gamma production in restimulated CD4 + and CD8 + cells indicates memory type responsiveness .
1970729	0	CD4	22,25	Interleukin_4	0,13	CD4	Interleukin 4	920	3565	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD4	40,43	Interleukin_4	0,13	CD4	Interleukin 4	920	3565	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
7869030	0	CD4	28,31	Interleukin_4	0,13	CD4	Interleukin 4	920	3565	Gene	Gene	cells|nummod|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Interleukin_4 production by CD4 + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type .
19136960	0	CD4	101,104	Interleukin_7	0,13	CD4	Interleukin 7	920	3574	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells regulates|dobj|proliferation regulates|nsubj|END_ENTITY	Interleukin_7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4 + T cells .
16424186	0	CD4	111,114	Itk	12,15	CD4	Itk	12504(Tax:10090)	16428(Tax:10090)	Gene	Gene	help|compound|START_ENTITY virus_infection|nmod|help required|xcomp|virus_infection required|nsubjpass|END_ENTITY	Tec kinases Itk and Rlk are required for CD8 + T cell responses to virus_infection independent of their role in CD4 + T cell help .
18453573	0	CD4	34,37	Itk	86,89	CD4	Itk	12504(Tax:10090)	16428(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|dobj|requirements requirements|nmod|END_ENTITY	Naive and innate memory phenotype CD4 + T cells have different requirements for active Itk for their development .
19443662	0	CD4	24,27	Itk	66,69	CD4	Itk	12504(Tax:10090)	16428(Tax:10090)	Gene	Gene	development|nmod|START_ENTITY +|nsubj|development +|nmod|absence absence|nmod|results results|compound|END_ENTITY	Enhanced development of CD4 + gammadelta T cells in the absence of Itk results in elevated IgE production .
25568116	0	CD4	52,55	Itk	0,3	CD4	Itk	12504(Tax:10090)	16428(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY END_ENTITY|nmod|Activation	Itk Signals Promote Neuroinflammation by Regulating CD4 + T-Cell Activation and Trafficking .
22728763	0	CD4	89,92	Janus_tyrosine_kinase_3	10,33	CD4	Janus tyrosine kinase 3	12504(Tax:10090)	16453(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	Targeting Janus_tyrosine_kinase_3 -LRB- JAK3 -RRB- with an inhibitor induces secretion of TGF-b by CD4 + T cells .
24337749	0	CD4	14,17	KLRG1	0,5	CD4	KLRG1	920	10219	Gene	Gene	responses|compound|START_ENTITY responses|nummod|END_ENTITY	KLRG1 impairs CD4 + T cell responses via p16ink4a and p27kip1 pathways : role in hepatitis_B_vaccine_failure in individuals with hepatitis_C_virus infection .
25330112	0	CD4	98,101	L-Selectin	60,70	CD4	L-Selectin	920	6402	Gene	Gene	Cells|compound|START_ENTITY Suppression|nmod|Cells Suppression|appos|END_ENTITY	Suppression of Foxo1 Activity and Down-Modulation of CD62L -LRB- L-Selectin -RRB- in HIV-1 Infected Resting CD4 T Cells .
10967018	0	CD4	58,61	L-selectin	77,87	CD4	L-selectin	920	6402	Gene	Gene	START_ENTITY|appos|CD45RO CD45RO|appos|END_ENTITY	Adenoids provide a microenvironment for the generation of CD4 -LRB- + -RRB- , CD45RO -LRB- + -RRB- , L-selectin -LRB- - -RRB- , CXCR4 -LRB- + -RRB- , CCR5 -LRB- + -RRB- T lymphocytes , a lymphocyte phenotype found in the middle_ear_effusion .
11859099	0	CD4	98,101	L-selectin	65,75	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY show|dobj|+ show|nsubj|ligands ligands|amod|END_ENTITY	Fucosyltransferase_VII-deficient mice with defective E - , P - , and L-selectin ligands show impaired CD4 + and CD8 + T cell migration into the skin , but normal extravasation into visceral organs .
11882033	0	CD4	71,74	L-selectin	57,67	CD4	L-selectin	920	6402	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential expression of beta1 and beta2 integrins and L-selectin on CD4 + and CD8 + T lymphocytes in human blood : comparative analysis between isolated cells , whole blood samples and cryopreserved preparations .
12193715	0	CD4	21,24	L-selectin	95,105	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY subpopulation|nmod|+ splenocytes|nsubj|subpopulation splenocytes|ccomp|expresses expresses|dobj|levels levels|amod|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
12355444	0	CD4	77,80	L-selectin	39,49	CD4	L-selectin	12504(Tax:10090)	6402	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Inhibition of TCR-mediated shedding of L-selectin -LRB- CD62L -RRB- on human and mouse CD4 + T cells by metalloproteinase inhibition : analysis of the regulation of Th1/Th2 function .
12496379	0	CD4	79,82	L-selectin	14,24	CD4	L-selectin	920	6402	Gene	Gene	cells|nummod|START_ENTITY Cutting|nsubj|cells Cutting|dobj|edge edge|dep|expression expression|amod|END_ENTITY	Cutting edge : L-selectin -LRB- CD62L -RRB- expression distinguishes small resting memory CD4 + T cells that preferentially respond to recall antigen .
15292057	0	CD4	42,45	L-selectin	27,37	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	L-Selectin|acl|START_ENTITY L-Selectin|nmod|END_ENTITY	L-Selectin -LRB- hi -RRB- but not the L-selectin -LRB- lo -RRB- CD4 +25 + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection .
15699171	0	CD4	72,75	L-selectin	0,10	CD4	L-selectin	920	6402	Gene	Gene	recruitment|compound|START_ENTITY participate|nmod|recruitment participate|nsubj|beta beta|amod|END_ENTITY	L-selectin , alpha 4 beta 1 , and alpha 4 beta 7 integrins participate in CD4 + T cell recruitment to chronically inflamed small intestine .
16105972	0	CD4	39,42	L-selectin	0,10	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY integrin|nmod|cells integrin|amod|END_ENTITY	L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute_colitis of graft-versus-host_disease .
17182566	0	CD4	5,8	L-selectin	47,57	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	migration|compound|START_ENTITY requires|nsubj|migration requires|dobj|expression expression|amod|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
17182566	0	CD4	5,8	L-selectin	70,80	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	migration|compound|START_ENTITY requires|nsubj|migration requires|parataxis|balances balances|nsubj|regulation regulation|amod|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
19419934	0	CD4	65,68	L-selectin	24,34	CD8	L-selectin	925	6402	Gene	Gene	+|compound|START_ENTITY blood|dep|+ +|dep|blood +|nsubj|percentage percentage|nmod|+ +|compound|END_ENTITY	Increased percentage of L-selectin + and ICAM-1 + peripheral blood CD4 + / CD8 + T cells in active Graves ' _ ophthalmopathy .
19553533	0	CD4	72,75	L-selectin	47,57	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY down-regulate|nmod|+ down-regulate|dobj|expression expression|amod|END_ENTITY	Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4 + and CD8 + T cells .
7525854	0	CD4	15,18	L-selectin	64,74	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Entry|nmod|cells requires|nsubj|Entry requires|xcomp|END_ENTITY	Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin .
8698378	0	CD4	91,94	L-selectin	14,24	CD4	L-selectin	920	6402	Gene	Gene	cells|compound|START_ENTITY discriminates|dobj|cells discriminates|nsubj|Expression Expression|nmod|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
8921958	0	CD4	0,3	L-selectin	33,43	CD4	L-selectin	24932(Tax:10116)	29259(Tax:10116)	Gene	Gene	CD8|compound|START_ENTITY CD8|dep|thymocytes thymocytes|acl:relcl|express express|ccomp|protect protect|nsubj|END_ENTITY	CD4 + CD8 - thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer .
9111498	0	CD4	65,68	L-selectin	97,107	CD4	L-selectin	920	6402	Gene	Gene	cells|compound|START_ENTITY cells|nmod|expression expression|amod|END_ENTITY	Severe allergic_reactions to foods are predicted by increases of CD4 + CD45RO + T cells and loss of L-selectin expression .
9174603	0	CD4	38,41	L-selectin	0,10	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	naive|dep|START_ENTITY trafficking|amod|naive essential|nmod|trafficking essential|nsubj|END_ENTITY	L-selectin is not essential for naive CD4 cell trafficking or development of primary responses in Peyer 's patches .
9531305	0	CD4	79,82	L-selectin	16,26	CD4	L-selectin	920	6402	Gene	Gene	lymphocytes|compound|START_ENTITY generation|nmod|lymphocytes promotes|dobj|generation promotes|nsubj|Purification Purification|nmod|cells cells|amod|END_ENTITY	Purification of L-selectin -LRB- low -RRB- cells promotes the generation of highly potent CD4 antitumor effector T lymphocytes .
9725264	0	CD4	33,36	L-selectin	60,70	CD4	L-selectin	12504(Tax:10090)	20343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY thymocytes|nsubj|+ thymocytes|xcomp|expressing expressing|dobj|tolerance tolerance|amod|END_ENTITY	Mature mainstream TCR_alpha beta + CD4 + thymocytes expressing L-selectin mediate `` active tolerance '' in the nonobese diabetic mouse .
9893333	0	CD4	47,50	L-selectin	15,25	CD4	L-selectin	920	6402	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	-LSB- Expression of L-selectin on peripheral memory CD4 + T cells in atopic_diseases -RSB- .
1866603	0	CD4	16,19	L3T4	21,25	CD4	L3T4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	A novel form of CD4 -LRB- L3T4 -RRB- mRNA in the murine fetal liver results in cell-surface expression of the L3T4 antigen .
25695838	0	CD4	18,21	LAG3	31,35	CD4	LAG3	920	3902	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nsubj|CD25	TGF-b3-expressing CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- LAG3 -LRB- + -RRB- regulatory T cells control humoral immune responses .
21131422	0	CD4	33,36	LAGE-1	58,64	CD4	LAGE-1	920	30848	Gene	Gene	+|compound|START_ENTITY hierarchy|nmod|+ T|nsubj|hierarchy T|nmod|END_ENTITY	Epitope hierarchy of spontaneous CD4 + T cell responses to LAGE-1 .
16540527	0	CD4	109,112	LAP	113,116	CD4	LAP	12504(Tax:10090)	219103(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Recovery from experimental_allergic_encephalomyelitis is TGF-beta dependent and associated with increases in CD4 + LAP + and CD4 + CD25 + T cells .
16715091	0	CD4	79,82	LAP	90,93	CD4	LAP	920	7040	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|T T|compound|END_ENTITY	Oral CD3-specific antibody suppresses autoimmune_encephalomyelitis by inducing CD4 + CD25 - LAP + T cells .
18941193	0	CD4	73,76	LAP	84,87	CD4	LAP	12504(Tax:10090)	13708(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY inducing|dobj|CD25 lupus|advcl|inducing lupus|parataxis|+ +|nsubj|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
21124798	0	CD4	47,50	LAP	22,25	CD4	LAP	12504(Tax:10090)	219103(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
22552859	0	CD4	0,3	LAP	4,7	CD4	LAP	12504(Tax:10090)	219103(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + LAP + and CD4 + CD25 + Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE - / - mice .
22939403	0	CD4	106,109	LAP	110,113	CD4	LAP	12504(Tax:10090)	13708(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Hsp65-producing Lactococcus_lactis prevents experimental_autoimmune_encephalomyelitis in mice by inducing CD4 + LAP + regulatory T cells .
26004193	0	CD4	59,62	LAP	69,72	CD4	LAP	12504(Tax:10090)	13708(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vitamin_A supplementation leads to increases in regulatory CD4 + Foxp3 + LAP + T cells in mice .
26582240	0	CD4	23,26	LAP	0,3	CD4	LAP	920	7040	Gene	Gene	CD25|compound|START_ENTITY Subset|nmod|CD25 Subset|compound|END_ENTITY	LAP TGF-Beta Subset of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- - -RRB- Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients .
11412874	0	CD4	20,23	LFA-1	0,5	CD4	LFA-1	920	3683	Gene	Gene	CD45RO|compound|START_ENTITY expression|nmod|CD45RO expression|compound|END_ENTITY	LFA-1 expression on CD4 -LRB- + -RRB- CD45RO -LRB- + -RRB- peripheral blood T-lymphocytes in RR MS : effects induced by rIFNbeta-1a .
12064793	0	CD4	56,59	LFA-1	24,29	CD4	LFA-1	920	3683	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|appos|END_ENTITY	Up-regulation of CD11a -LRB- LFA-1 -RRB- expression on peripheral CD4 + T cells in primary_biliary_cirrhosis .
1347547	1	CD4	88,91	LFA-1	158,163	CD4	LFA-1	920	3683	Gene	Gene	cells|compound|START_ENTITY require|nsubj|cells require|dobj|signal signal|acl|mediated mediated|nmod|pathway pathway|compound|END_ENTITY	Naive CD4 +45 RA + T cells require a costimulatory signal mediated through the LFA-1 / ICAM-1 pathway .
1350461	0	CD4	115,118	LFA-1	26,31	CD4	LFA-1	12504(Tax:10090)	16414(Tax:10090)	Gene	Gene	+|compound|START_ENTITY activation|nmod|+ frequency|nmod|activation enhances|dobj|frequency enhances|nsubj|Co-engagement Co-engagement|nmod|CD3 CD3|nmod|molecules molecules|amod|END_ENTITY	Co-engagement of CD3 with LFA-1 or ICAM-1 adhesion molecules enhances the frequency of activation of single murine CD4 + and CD8 + T cells and induces synthesis of IL-3 and IFN-gamma but not IL-4 or IL-6 .
15383575	0	CD4	9,12	LFA-1	0,5	CD4	LFA-1	12504(Tax:10090)	16408(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	LFA-1 on CD4 + T cells is required for optimal antigen-dependent activation in vivo .
15544853	0	CD4	78,81	LFA-1	28,33	CD4	LFA-1	920	3683	Gene	Gene	+|compound|START_ENTITY modulating|nmod|+ down-regulates|advcl|modulating down-regulates|dobj|activation activation|compound|END_ENTITY	Somatostatin down-regulates LFA-1 activation by modulating Rap1 expression in CD4 + and CD8 + T cells .
16002691	0	CD4	144,147	LFA-1	14,19	CD4	LFA-1	920	3683	Gene	Gene	lymphocytes|compound|START_ENTITY entry|nmod|lymphocytes efficiency|nmod|entry modulates|dobj|efficiency modulates|nsubj|Regulation Regulation|acl|remodeling remodeling|nsubj|activity activity|compound|END_ENTITY	Regulation of LFA-1 activity through cytoskeleton remodeling and signaling components modulates the efficiency of HIV_type-1 entry in activated CD4 + T lymphocytes .
1671082	0	CD4	48,51	LFA-1	92,97	CD4	LFA-1	920	3683	Gene	Gene	T|compound|START_ENTITY infection|nmod|T lymphocytes|nsubj|infection lymphocytes|xcomp|deficient deficient|nmod|END_ENTITY	Human_immunodeficiency_virus _ -LRB- HIV -RRB- _ infection in CD4 + T lymphocytes genetically deficient in LFA-1 : LFA-1 is required for HIV-mediated cell fusion but not for viral transmission .
1671082	0	CD4	48,51	LFA-1	99,104	CD4	LFA-1	920	3683	Gene	Gene	T|compound|START_ENTITY infection|nmod|T lymphocytes|nsubj|infection _|ccomp|lymphocytes _|parataxis|required required|nsubjpass|END_ENTITY	Human_immunodeficiency_virus _ -LRB- HIV -RRB- _ infection in CD4 + T lymphocytes genetically deficient in LFA-1 : LFA-1 is required for HIV-mediated cell fusion but not for viral transmission .
1706184	0	CD4	66,69	LFA-1	12,17	CD4	LFA-1	920	3683	Gene	Gene	T-cells|compound|START_ENTITY involved|nmod|T-cells involved|nsubj|epitopes epitopes|appos|END_ENTITY	CD11a/CD18 -LRB- LFA-1 -RRB- epitopes involved in syncytium formation among CD4 + T-cells following cell free HIV-1_infection .
19235605	0	CD4	54,57	LFA-1	45,50	CD4	LFA-1	920	3683	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	The effect of rhG-CSF on the conformation of LFA-1 on CD4 + T cells in hemopoietic stem cell transplantation .
21850260	0	CD4	38,41	LFA-1	29,34	CD4	LFA-1	920	3683	Gene	Gene	T-lymphocytes|compound|START_ENTITY activates|nmod|T-lymphocytes activates|dobj|END_ENTITY	HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin -LRB- LtxA -RRB- .
26740009	0	CD4	16,19	LFA-1	87,92	CD4	LFA-1	12504(Tax:10090)	16414(Tax:10090)	Gene	Gene	T-cell|nsubj|START_ENTITY T-cell|nmod|END_ENTITY	PI3K promotes CD4 -LRB- + -RRB- T-cell interactions with antigen-presenting_cells by increasing LFA-1 binding to ICAM-1 .
7522975	0	CD4	62,65	LFA-1	8,13	CD4	LFA-1	920	3683	Gene	Gene	adhesion|compound|START_ENTITY receptors|nmod|adhesion surface|dobj|receptors surface|nsubj|Role Role|nmod|END_ENTITY	Role of LFA-1 , CD2 , VLA-5 / CD29 , and CD43 surface receptors in CD4 + T cell adhesion to B cells .
7911073	0	CD4	0,3	LFA-1	34,39	CD4	LFA-1	12504(Tax:10090)	16408(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY require|nsubj|cells require|dobj|adhesion adhesion|nmod|ICAM-1 ICAM-1|compound|END_ENTITY	CD4 + T cells require adhesion via LFA-1 / ICAM-1 to induce target apoptosis in TNF-independent pathway .
8547030	0	CD4	99,102	LFA-1	11,16	CD4	LFA-1	920	3683	Gene	Gene	cells|compound|START_ENTITY critical|nmod|cells critical|nsubj|interaction interaction|compound|END_ENTITY	The ICAM-3 / LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4 + T cells .
9420139	0	CD4	127,130	LFA-1	49,54	CD4	LFA-1	920	3683	Gene	Gene	subset|compound|START_ENTITY role|nmod|subset role|nmod|molecules molecules|amod|interleukin-7 interleukin-7|nmod|induction induction|nmod|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
9837689	0	CD4	65,68	LFA-1	12,17	CD4	LFA-1	24932(Tax:10116)	308995(Tax:10116)	Gene	Gene	T|compound|START_ENTITY associated|nmod|T associated|nsubjpass|Decrease Decrease|nmod|END_ENTITY	Decrease of LFA-1 is associated with upregulation of TGF-beta in CD4 -LRB- + -RRB- T cell clones derived from rats nasally tolerized against experimental autoimmune_myasthenia_gravis .
18490732	0	CD4	46,49	Latency-associated_peptide	0,26	CD4	Latency-associated peptide	920	7040	Gene	Gene	subset|compound|START_ENTITY identifies|dobj|subset identifies|nsubj|END_ENTITY	Latency-associated_peptide identifies a novel CD4 + CD25 + regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis .
10843386	0	CD4	100,103	Lck	70,73	CD4	Lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	thymocytes|compound|START_ENTITY differentiation|nmod|thymocytes reveals|nmod|differentiation reveals|dobj|role role|nmod|END_ENTITY	Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes .
11828322	0	CD4	30,33	Lck	14,17	CD4	Lck	920	3932	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of Lck activity by CD4 and CD28 in the immunological synapse .
12517957	0	CD4	27,30	Lck	82,85	CD4	Lck	920	3932	Gene	Gene	distribution|nmod|START_ENTITY depends|nsubj|distribution depends|nmod|palmitoylation palmitoylation|nmod|END_ENTITY	Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck , and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling .
15247914	0	CD4	0,3	Lck	59,62	CD4	Lck	920	3932	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|coordinating coordinating|dobj|accumulation accumulation|compound|END_ENTITY	CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse .
16631599	0	CD4	26,29	Lck	78,81	CD4	Lck	920	3932	Gene	Gene	START_ENTITY|nmod|dissociation dissociation|nmod|p56 p56|appos|END_ENTITY	Lipoic_acid downmodulates CD4 from human T lymphocytes by dissociation of p56 -LRB- Lck -RRB- .
18031691	0	CD4	0,3	Lck	29,32	CD4	Lck	920	3932	Gene	Gene	START_ENTITY|parataxis|hogging hogging|dobj|END_ENTITY	CD4 and CD8 : hogging all the Lck .
19019957	0	CD4	18,21	Lck	61,64	CD4	Lck	920	3932	Gene	Gene	receptor|compound|START_ENTITY Engagement|nmod|receptor affects|nsubj|Engagement affects|dobj|redistribution redistribution|nmod|END_ENTITY	Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells : implications for T-cell activation during human_immunodeficiency_virus_type_1_infection .
20837541	0	CD4	0,3	Lck	63,66	CD4	Lck	920	3932	Gene	Gene	acts|nsubj|START_ENTITY acts|xcomp|enhance enhance|dobj|delivery delivery|compound|END_ENTITY	CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery .
22529380	0	CD4	39,42	Lck	28,31	CD4	Lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	maturation|compound|START_ENTITY END_ENTITY|nmod|maturation	Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold .
8887682	0	CD4	50,53	Lck	77,80	CD4	Lck	920	3932	Gene	Gene	Binding|nmod|START_ENTITY induces|nsubj|Binding induces|dobj|association association|nmod|END_ENTITY	Binding of human_immunodeficiency_virus_type_1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway .
2472027	0	CD4	0,3	Leu-7	5,10	CD4	Leu-7	920	27087	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	CD4 + / Leu-7 + large granular lymphocytes in long-term renal allograft recipients .
2570740	0	CD4	57,60	Leu-8	63,68	CD4	Leu-8	920	6402	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Defective immunoregulation in primary_biliary_cirrhosis : CD4 + , Leu-8 + T cells have abnormal activation and suppressor function in vitro .
7515343	0	CD4	51,54	Leu-8	72,77	CD4	Leu-8	920	6402	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells proliferation|acl|bearing bearing|dobj|receptor receptor|compound|END_ENTITY	Defective proliferation and regulatory function of CD4 + T cells bearing Leu-8 homing receptor in primary_biliary_cirrhosis .
1712684	3	CD4	554,557	Leu8	558,562	CD8	Leu8	925	6402	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	In normal subjects , CD4 + Leu8 + cells are necessary for the initiation of the AMLR response , and sequentially lead to activation and proliferation of both CD4 + Leu8 - cells and CD8 + Leu8 + cells .
1725219	0	CD4	138,141	Leu8	174,178	CD4	Leu8	920	6402	Gene	Gene	lymphocytes|appos|START_ENTITY expressing|nsubj|lymphocytes expressing|ccomp|regulated regulated|nsubjpass|END_ENTITY	Pituitary-adrenal-immune system in normal subjects and in patients with anorexia_nervosa : the number of circulating helper T lymphocytes -LRB- CD4 -RRB- expressing the homing receptor Leu8 is regulated in part by pituitary-adrenal products .
8794952	0	CD4	50,53	Leukocyte_chemotactic_factor	0,28	CD4	Leukocyte chemotactic factor	920	3603	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Leukocyte_chemotactic_factor , a natural ligand to CD4 , is expressed by lymphocytes and microglial cells of the MS plaque .
11009081	0	CD4	46,49	Ly49	27,31	CD4	Ly49	12504(Tax:10090)	17055(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	Differential regulation of Ly49 expression on CD4 + and CD4-CD8 - -LRB- double negative -RRB- NK1 .1 + T cells .
1716614	0	CD4	53,56	Lymphokine	0,10	CD4	Lymphokine	920	3558	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Lymphokine secretion and cytotoxic activity of human CD4 + T-cell clones against Bordetella_pertussis .
17570210	0	CD4	0,3	MICA	91,95	CD4	MICA	920	100507436	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|mediate mediate|nmod|interactions interactions|compound|END_ENTITY	CD4 + NKG2D + T cells in Crohn 's _ disease mediate inflammatory and cytotoxic responses through MICA interactions .
19428548	0	CD4	80,83	MIF	67,70	CD4	MIF	920	4282	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	NF-kappaB inhibition leads to increased synthesis and secretion of MIF in human CD4 + T cells .
26043155	0	CD4	29,32	MTOR	56,60	CD4	MTOR	920	2475	Gene	Gene	cells|compound|START_ENTITY survival|nmod|cells promotes|dobj|survival promotes|advcl|restricting restricting|dobj|END_ENTITY	TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy .
9241529	0	CD4	44,47	Mac-1	49,54	CD4	Mac-1	12504(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The appearance of unusual phenotypic cells -LRB- CD4 + Mac-1 + class II + -RRB- in the liver of -LRB- NZW x BXSB -RRB- F1 mice is possibly an animal model for autoimmune_hepatitis .
24355664	0	CD4	48,51	MiR-568	0,7	CD4	MiR-568	920	693153	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells inhibits|dobj|activation inhibits|nsubj|END_ENTITY	MiR-568 inhibits the activation and function of CD4 T cells and Treg cells by targeting NFAT5 .
21085192	0	CD4	26,29	MicroRNA-21	0,11	CD4	MicroRNA-21	920	406991	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	MicroRNA-21 expression in CD4 + T cells is regulated by STAT3 and is pathologically involved in S zary syndrome .
26978146	0	CD4	34,37	MicroRNA-31	19,30	CD4	MicroRNA-31	920	407035	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Down-regulation of MicroRNA-31 in CD4 + T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing .
18209086	0	CD4	62,65	MyD88	39,44	CD4	MyD88	12504(Tax:10090)	17874(Tax:10090)	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|myeloid_differentiation_factor_88 myeloid_differentiation_factor_88|appos|END_ENTITY	The myeloid_differentiation_factor_88 -LRB- MyD88 -RRB- is required for CD4 + T cell effector function in a murine model of inflammatory_bowel_disease .
19052080	0	CD4	30,33	MyD88	0,5	CD4	MyD88	920	4615	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	MyD88 intrinsically regulates CD4 T-cell responses .
21498664	0	CD4	59,62	MyD88	19,24	CD4	MyD88	12504(Tax:10090)	17874(Tax:10090)	Gene	Gene	response|compound|START_ENTITY shape|dobj|response shape|nsubj|signaling signaling|nmod|END_ENTITY	TLR4 signaling via MyD88 and TRIF differentially shape the CD4 + T cell response to Porphyromonas_gingivalis_hemagglutinin_B .
23526822	0	CD4	19,22	MyD88	0,5	CD4	MyD88	12504(Tax:10090)	17874(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	MyD88 signaling in CD4 T cells promotes IFN-y production and hematopoietic progenitor cell expansion in response to intracellular bacterial_infection .
24038087	0	CD4	0,3	MyD88	26,31	CD4	MyD88	920	4615	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	CD4 + T cell expression of MyD88 is essential for normal resolution of Chlamydia_muridarum_genital_tract_infection .
24439266	0	CD4	48,51	MyD88	39,44	CD4	MyD88	12504(Tax:10090)	17874(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Signaling through the adaptor molecule MyD88 in CD4 + T cells is required to overcome suppression by regulatory T cells .
11175263	0	CD4	69,72	NF-kappa_B	12,22	CD4	NF-kappa B	12504(Tax:10090)	18033(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY transactivation|nmod|CD8 transactivation|amod|END_ENTITY	The lack of NF-kappa_B transactivation and PKC_epsilon expression in CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes correlates with negative selection .
1604322	0	CD4	48,51	NF-kappa_B	0,10	CD4	NF-kappa B	920	4790	Gene	Gene	T|compound|START_ENTITY regulation|nmod|T regulation|amod|END_ENTITY	NF-kappa_B subunit regulation in nontransformed CD4 + T lymphocytes .
7915519	0	CD4	31,34	NF-kappa_B	70,80	CD4	NF-kappa B	920	4790	Gene	Gene	molecule|compound|START_ENTITY transduced|nmod|molecule Signals|acl|transduced activate|nsubj|Signals activate|dobj|END_ENTITY	Signals transduced through the CD4 molecule on T lymphocytes activate NF-kappa_B .
8878524	0	CD4	53,56	NF-kappa_B	25,35	CD4	NF-kappa B	920	4790	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Inorganic lead activates NF-kappa_B in primary human CD4 + T lymphocytes .
9571986	0	CD4	85,88	NF-kappa_B	57,67	CD4	NF-kappa B	920	4790	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Hydroquinone , a reactive metabolite of benzene , inhibits NF-kappa_B in primary human CD4 + T lymphocytes .
21282105	0	CD4	92,95	NFAT1	76,81	CD4	NFAT1	920	4773	Gene	Gene	cells|compound|START_ENTITY 1|nmod|cells 1|appos|END_ENTITY	Minocycline suppresses activation of nuclear factor of activated T cells 1 -LRB- NFAT1 -RRB- in human CD4 + T cells .
22865456	0	CD4	39,42	NFAT1	0,5	CD4	NFAT1	12504(Tax:10090)	18019(Tax:10090)	Gene	Gene	T|compound|START_ENTITY anergy|nmod|T cells|compound|anergy supports|dobj|cells supports|nsubj|END_ENTITY	NFAT1 supports tumor-induced anergy of CD4 -LRB- + -RRB- T cells .
24173147	0	CD4	118,121	NFAT1	94,99	CD4	NFAT1	920	4773	Gene	Gene	proliferation|compound|START_ENTITY END_ENTITY|nmod|proliferation	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
24173147	0	CD4	40,43	NFAT1	94,99	CD4	NFAT1	920	4773	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ associated|nsubjpass|expression associated|nmod|END_ENTITY	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
25595785	0	CD4	63,66	NFAT1	0,5	CD4	NFAT1	12504(Tax:10090)	18019(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4 + T Cells in Health and Disease .
11927628	0	CD4	90,93	NK1	82,85	CD4	NK1	12504(Tax:10090)	17059(Tax:10090)	Gene	Gene	CD1d-dependent|compound|START_ENTITY CD1d-dependent|nummod|.1 .1|compound|END_ENTITY	A natural killer T -LRB- NKT -RRB- cell developmental pathway iInvolving a thymus-dependent NK1 .1 -LRB- - -RRB- CD4 -LRB- + -RRB- CD1d-dependent precursor stage .
26405570	0	CD4	100,103	NK1	20,23	CD4	NK1	920	11126	Gene	Gene	T|compound|START_ENTITY melanoma|nmod|T cells|amod|melanoma rejection|nmod|cells enhances|dobj|rejection enhances|nsubj|Depletion Depletion|nmod|B220 B220|dep|cells cells|amod|.1 .1|compound|END_ENTITY	Depletion of B220 -LRB- + -RRB- NK1 .1 -LRB- + -RRB- cells enhances the rejection of established melanoma by tumor-specific CD4 -LRB- + -RRB- T cells .
8006596	0	CD4	41,44	NK1	51,54	CD4	NK1	12504(Tax:10090)	17059(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY development|nmod|CD8 dependence|nmod|development dependence|dep|.1 .1|compound|END_ENTITY	Class I dependence of the development of CD4 + CD8 - NK1 .1 + thymocytes .
8617303	0	CD4	92,95	NK1	97,100	CD4	NK1	12504(Tax:10090)	17059(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Selectively impaired development of intestinal T cell receptor gamma delta + cells and liver CD4 + NK1 + T cell receptor alpha beta + cells in T_cell_factor-1-deficient mice .
9138017	0	CD4	34,37	NK1	38,41	CD4	NK1	12504(Tax:10090)	21333(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	TCR-mediated target cell lysis by CD4 + NK1 + liver T lymphocytes .
23396942	0	CD4	17,20	NKG2C	10,15	CD4	NKG2C	920	3822	Gene	Gene	target|compound|START_ENTITY target|compound|END_ENTITY	Cytotoxic NKG2C + CD4 T cells target oligodendrocytes in multiple_sclerosis .
17109473	0	CD4	36,39	NKG2D	27,32	CD4	NKG2D	920	22914	Gene	Gene	cells|compound|START_ENTITY Expression|nmod|cells Expression|nmod|END_ENTITY	Expression and function of NKG2D in CD4 + T cells specific for human_cytomegalovirus .
17570210	0	CD4	0,3	NKG2D	4,9	CD4	NKG2D	920	22914	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + NKG2D + T cells in Crohn 's _ disease mediate inflammatory and cytotoxic responses through MICA interactions .
17962357	0	CD4	63,66	NKG2D	12,17	CD4	NKG2D	12504(Tax:10090)	27007(Tax:10090)	Gene	Gene	colitis|compound|START_ENTITY development|nmod|colitis prevents|dobj|development prevents|nsubj|Blockade Blockade|nmod|signaling signaling|compound|END_ENTITY	Blockade of NKG2D signaling prevents the development of murine CD4 + T cell-mediated colitis .
21210234	0	CD4	20,23	NKG2D	0,5	CD4	NKG2D	920	22914	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	NKG2D expression in CD4 + T lymphocytes as a marker of senescence in the aged immune system .
21210234	3	CD4	466,469	NKG2D	457,462	CD4	NKG2D	920	22914	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Typical features of cell immunosenescence are characteristics of pathologies in which the aberrant expression of NKG2D in CD4 + T cells has been described .
22384114	0	CD4	67,70	NKG2D	100,105	CD4	NKG2D	920	22914	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells mediated|nsubjpass|cells mediated|nmod|END_ENTITY	Cytotoxicity of CD56 -LRB- bright -RRB- NK cells towards autologous activated CD4 + T cells is mediated through NKG2D , LFA-1 and TRAIL and dampened via CD94/NKG2A .
22870231	0	CD4	88,91	NKG2D	44,49	CD4	NKG2D	920	22914	Gene	Gene	T-cells|compound|START_ENTITY T-cells|nummod|END_ENTITY	Regulation and gene expression profiling of NKG2D positive human_cytomegalovirus-primed CD4 + T-cells .
24282598	0	CD4	0,3	NKG2D	4,9	CD4	NKG2D	920	22914	Gene	Gene	exhibit|compound|START_ENTITY exhibit|compound|END_ENTITY	CD4 + NKG2D + T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation .
24708417	0	CD4	0,3	NKG2D	31,36	CD4	NKG2D	12504(Tax:10090)	27007(Tax:10090)	Gene	Gene	NKG2D|compound|START_ENTITY T|nsubj|NKG2D T|ccomp|induce induce|dobj|down-regulation down-regulation|compound|END_ENTITY	CD4 -LRB- + -RRB- NKG2D -LRB- + -RRB- T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1 transgenic_mice .
24761885	0	CD4	5,8	NKG2D	73,78	CD4	NKG2D	920	22914	Gene	Gene	+|compound|START_ENTITY lymphocyte|nsubj|+ lymphocyte|ccomp|receptors receptors|dobj|END_ENTITY	CD3 + CD4 + and CD3 + CD8 + lymphocyte subgroups and their surface receptors NKG2D and NKG2A in patients with non-small cell lung_cancer .
9232437	0	CD4	61,64	NKRP1A	0,6	CD4	NKRP1A	920	3820	Gene	Gene	lymphocytes|nummod|START_ENTITY migration|nmod|lymphocytes involved|nmod|migration involved|nsubjpass|molecule molecule|compound|END_ENTITY	NKRP1A molecule is involved in transendothelial migration of CD4 + human T lymphocytes .
9341779	0	CD4	38,41	NKRP1A	43,49	CD4	NKRP1A	920	3820	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Phenotypic and functional analysis of CD4 + NKRP1A + human T lymphocytes .
17303697	0	CD4	26,29	NKa	31,34	CD4	NKa	920	6863	Gene	Gene	START_ENTITY|dep|CD8 CD8|dep|+ +|compound|END_ENTITY	Monoclonal TCR-Vbeta13 .1 + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis : evidence for an antigen-driven chronic T-cell stimulation origin .
18768393	0	CD4	44,47	NKa	49,52	CD4	NKa	920	6863	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Expanded cells in monoclonal TCR-alphabeta + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis recognize hCMV antigens .
20739776	0	CD4	0,3	NKa	7,10	CD4	NKa	920	6863	Gene	Gene	+|compound|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|nummod|+ T-cell_large_granular_lymphocytic_leukemia|dep|+ +|compound|END_ENTITY	CD4 + / NKa _ + / CD8 -LRB- dim + -RRB- T-cell_large_granular_lymphocytic_leukemia : a rare entity .
18097220	0	CD4	54,57	NKp44L	74,80	CD4	NKp44L	920	55904	Gene	Gene	relationship|nmod|START_ENTITY influences|dobj|relationship influences|nsubj|depletion depletion|appos|expression expression|amod|END_ENTITY	CCR5 or CXCR4 use influences the relationship between CD4 cell depletion , NKp44L expression and NK cytotoxicity in SHIV-infected macaques .
19424050	0	CD4	79,82	NKp44L	58,64	CD4	NKp44L	920	55904	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|expression expression|amod|END_ENTITY	HIV escape from natural killer cytotoxicity : nef inhibits NKp44L expression on CD4 + T cells .
24179999	0	CD4	21,24	NKp44L	0,6	CD4	NKp44L	920	55904	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	NKp44L expression on CD4 + T cells is associated with impaired_immunological_recovery_in_HIV-infected patients under highly active antiretroviral therapy .
10878395	0	CD4	18,21	NY-ESO-1	44,52	CD4	NY-ESO-1	920	246100	Gene	Gene	cell|compound|START_ENTITY Identification|nmod|cell epitopes|nsubj|Identification epitopes|nmod|END_ENTITY	Identification of CD4 + T cell epitopes from NY-ESO-1 presented by HLA-DR molecules .
10987311	0	CD4	79,82	NY-ESO-1	0,8	CD4	NY-ESO-1	920	246100	Gene	Gene	cells|compound|START_ENTITY recognized|nmod|cells epitopes|acl|recognized DRB1|dep|epitopes DRB1|nsubj|encodes encodes|compound|END_ENTITY	NY-ESO-1 encodes DRB1 * 0401-restricted epitopes recognized by melanoma-reactive CD4 + T cells .
11259659	0	CD4	0,3	NY-ESO-1	134,142	CD4	NY-ESO-1	920	246100	Gene	Gene	T|nsubj|START_ENTITY T|nmod|NY-ESO-1 NY-ESO-1|acl|presented presented|nmod|allele allele|dep|association association|nmod|production production|compound|END_ENTITY	CD4 -LRB- + -RRB- T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele : association with NY-ESO-1 antibody production .
11259659	0	CD4	0,3	NY-ESO-1	67,75	CD4	NY-ESO-1	920	246100	Gene	Gene	T|nsubj|START_ENTITY T|nmod|END_ENTITY	CD4 -LRB- + -RRB- T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele : association with NY-ESO-1 antibody production .
12853579	0	CD4	30,33	NY-ESO-1	60,68	CD4	NY-ESO-1	920	246100	Gene	Gene	T|compound|START_ENTITY Survey|nmod|T Survey|dep|responses responses|nmod|END_ENTITY	Survey of naturally occurring CD4 + T cell responses against NY-ESO-1 in cancer patients : correlation with antibody responses .
15197261	0	CD4	15,18	NY-ESO-1	82,90	CD4	NY-ESO-1	920	246100	Gene	Gene	responses|compound|START_ENTITY identified|nsubj|responses identified|nmod|patient patient|acl|vaccinated vaccinated|nmod|END_ENTITY	Immunodominant CD4 + responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant .
15600300	0	CD4	91,94	NY-ESO-1	35,43	CD4	NY-ESO-1	920	246100	Gene	Gene	CD25|compound|START_ENTITY correlation|nmod|CD25 expression|dep|correlation expression|nmod|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
16152624	0	CD4	54,57	NY-ESO-1	22,30	CD4	NY-ESO-1	920	246100	Gene	Gene	cells|compound|START_ENTITY recognized|nmod|cells recognized|nsubj|Identification Identification|nmod|epitopes epitopes|compound|END_ENTITY	Identification of new NY-ESO-1 epitopes recognized by CD4 + T cells and presented by HLA-DQ_B1 03011 .
18565862	0	CD4	49,52	NY-ESO-1	70,78	CD4	NY-ESO-1	920	246100	Gene	Gene	cells|compound|START_ENTITY Treatment|nmod|cells Treatment|nmod|END_ENTITY	Treatment of metastatic_melanoma with autologous CD4 + T cells against NY-ESO-1 .
19531622	0	CD4	90,93	NY-ESO-1	29,37	CD4	NY-ESO-1	920	246100	Gene	Gene	responses|compound|START_ENTITY elicits|dobj|responses elicits|nsubj|Vaccination Vaccination|nmod|protein protein|compound|END_ENTITY	Vaccination with recombinant NY-ESO-1 protein elicits immunodominant HLA-DR52b-restricted CD4 + T cell responses with a conserved T cell receptor repertoire .
20368442	0	CD4	32,35	NY-ESO-1	14,22	CD4	NY-ESO-1	920	246100	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Monitoring of NY-ESO-1 specific CD4 + T cells using molecularly defined MHC class II/His-tag-peptide tetramers .
20665979	0	CD4	88,91	NY-ESO-1	12,20	CD4	NY-ESO-1	920	246100	Gene	Gene	cells|compound|START_ENTITY recognized|nmod|cells epitopes|parataxis|recognized epitopes|nsubj|END_ENTITY	Three novel NY-ESO-1 epitopes bound to DRB1 * 0803 , DQB1 * 0401 and DRB1 * 0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients .
20670945	0	CD4	30,33	NY-ESO-1	118,126	CD4	NY-ESO-1	920	246100	Gene	Gene	Assessment|nmod|START_ENTITY T|nsubj|Assessment T|nmod|region region|nmod|END_ENTITY	Assessment of vaccine-induced CD4 T cell responses to the 119-143 immunodominant region of the tumor-specific antigen NY-ESO-1 using DRB1 * 0101 tetramers .
24777968	0	CD4	0,3	NY-ESO-1	48,56	CD4	NY-ESO-1	920	246100	Gene	Gene	effectors|compound|START_ENTITY effectors|nmod|END_ENTITY	CD4 + T effectors specific for the tumor antigen NY-ESO-1 are highly enriched at ovarian_cancer sites and coexist with , but are distinct from , tumor-associated Treg .
25662405	0	CD4	52,55	NY-ESO-1	79,87	CD4	NY-ESO-1	920	246100	Gene	Gene	responses|amod|START_ENTITY responses|nmod|vaccine vaccine|compound|END_ENTITY	Low-dose cyclophosphamide enhances antigen-specific CD4 -LRB- + -RRB- T cell responses to NY-ESO-1 / ISCOMATRIX vaccine in patients with advanced melanoma .
26587312	0	CD4	0,3	NY-ESO-1	34,42	CD4	NY-ESO-1	920	246100	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|resist resist|nsubj|responses responses|nmod|antigen antigen|compound|END_ENTITY	CD4 -LRB- + -RRB- T helper cell responses to NY-ESO-1 tumor antigen in ovarian_cancer resist perversion into immunosuppressive Tregs .
26608910	0	CD4	76,79	NY-ESO-1	18,26	CD4	NY-ESO-1	920	246100	Gene	Gene	Cells|compound|START_ENTITY Mediates|nmod|Cells Mediates|nsubj|END_ENTITY	The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4 + T Cells after Intercellular Antigen Transfer .
10199403	0	CD4	12,15	Nef	55,58	CD4	Nef	920	6285	Gene	Gene	degradation|compound|START_ENTITY degradation|dep|motif motif|nmod|functions functions|compound|END_ENTITY	Nef-induced CD4 degradation : a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes .
10208934	0	CD4	66,69	Nef	6,9	CD4	Nef	920	6285	Gene	Gene	down-regulation|compound|START_ENTITY processes|nmod|down-regulation plays|nmod|processes plays|nsubj|END_ENTITY	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation : dissociation of the CD4-p56 -LRB- lck -RRB- complex and targeting of CD4 to lysosomes .
10375525	0	CD4	59,62	Nef	102,105	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	release|nmod|START_ENTITY Inhibition|nmod|release relieved|nsubjpass|Inhibition relieved|nmod|expression expression|nmod|protein protein|compound|END_ENTITY	Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein .
10375528	0	CD4	27,30	Nef	92,95	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	expression|nmod|START_ENTITY reduces|nsubj|expression reduces|advcl|blocking blocking|dobj|incorporation incorporation|nmod|manner manner|amod|END_ENTITY	Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef - and Vpu-inhibitable manner .
10477559	0	CD4	120,123	Nef	18,21	CD4	Nef	920	1490008(Tax:11723)	Gene	Gene	down-regulation|nmod|START_ENTITY sorting|nmod|down-regulation protein|acl|sorting utilizes|dobj|protein utilizes|nsubj|protein protein|compound|END_ENTITY	Cutting edge : SIV Nef protein utilizes both leucine - and tyrosine-based protein sorting pathways for down-regulation of CD4 .
10807905	0	CD4	76,79	Nef	59,62	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	down-regulation|compound|START_ENTITY critical|nmod|down-regulation END_ENTITY|amod|critical	The human thioesterase_II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation .
11086083	0	CD4	40,43	Nef	96,99	CD4	Nef	920	6285	Gene	Gene	lymphocytes|compound|START_ENTITY apoptosis|nmod|lymphocytes Resistance|nmod|apoptosis mediated|nsubjpass|Resistance mediated|nmod|macrophages macrophages|dep|role role|nmod|END_ENTITY	Resistance to apoptosis in HIV-infected CD4 + T lymphocytes is mediated by macrophages : role for Nef and immune activation in viral persistence .
11264384	0	CD4	90,93	Nef	75,78	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY protein|nmod|domain protein|compound|END_ENTITY	Direct in vitro binding of full-length human_immunodeficiency_virus_type_1 Nef protein to CD4 cytoplasmic domain .
11264386	0	CD4	12,15	Nef	91,94	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	downregulation|compound|START_ENTITY downregulation|parataxis|function function|nsubj|sequence sequence|nmod|END_ENTITY	Nef-induced CD4 downregulation : a diacidic sequence in human_immunodeficiency_virus_type_1 Nef does not function as a protein sorting motif through direct binding to beta-COP .
11581379	0	CD4	0,3	Nef	59,62	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	depletion|nummod|START_ENTITY depletion|amod|down-modulation down-modulation|nmod|correlates correlates|compound|END_ENTITY	CD4 down-modulation by human_immunodeficiency_virus_type_1 Nef correlates with the efficiency of viral replication and with CD4 -LRB- + -RRB- T-cell depletion in human lymphoid tissue ex vivo .
11907198	0	CD4	68,71	Nef	30,33	CD4	Nef	920	6285	Gene	Gene	cells|compound|START_ENTITY progression|nmod|cells delays|dobj|progression delays|nsubj|END_ENTITY	Simian_immunodeficiency_virus Nef protein delays the progression of CD4 + T cells through G1/S phase of the cell cycle .
11922627	0	CD4	29,32	Nef	78,81	CD4	Nef	920	6285	Gene	Gene	domain|compound|START_ENTITY helix|nmod|domain Presence|nmod|helix promotes|nsubj|Presence promotes|xcomp|binding binding|nmod|protein protein|compound|END_ENTITY	Presence of a helix in human CD4 cytoplasmic domain promotes binding to HIV-1 Nef protein .
11969293	0	CD4	85,88	Nef	6,9	CD4	Nef	920	6285	Gene	Gene	T|compound|START_ENTITY mechanism|nmod|T differentiation|dep|mechanism induces|dobj|differentiation induces|nsubj|END_ENTITY	HIV-1 Nef induces dendritic cell differentiation : a possible mechanism of uninfected CD4 -LRB- + -RRB- T cell activation .
12525647	0	CD4	67,70	Nef	87,90	CD4	Nef	920	6285	Gene	Gene	downregulation|nmod|START_ENTITY correlates|nsubj|downregulation correlates|nmod|enhancement enhancement|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis .
13679604	0	CD4	48,51	Nef	119,122	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	tail|nmod|START_ENTITY motif|nmod|tail required|nsubjpass|motif required|nmod|END_ENTITY	The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human_immunodeficiency_virus_type_1 Nef , but is critical for CD4 down-modulation .
14747534	0	CD4	97,100	Nef	36,39	CD4	Nef	920	6285	Gene	Gene	downmodulate|dobj|START_ENTITY rafts|ccomp|downmodulate rafts|nsubj|associates associates|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity .
14990729	0	CD4	34,37	Nef	14,17	CD4	Nef	920	6285	Gene	Gene	cells|nummod|START_ENTITY targets|dobj|cells targets|nsubj|protein protein|compound|END_ENTITY	Extracellular Nef protein targets CD4 + T cells for apoptosis by interacting with CXCR4 surface receptors .
15133044	0	CD4	28,31	Nef	21,24	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts .
15166428	0	CD4	134,137	Nef	0,3	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	ability|nmod|START_ENTITY shows|dobj|ability shows|nsubj|END_ENTITY	Nef from a primary isolate of human_immunodeficiency_virus_type_1 lacking the EE -LRB- 155 -RRB- region shows decreased ability to down-regulate CD4 .
15258149	0	CD4	77,80	Nef	99,102	CD4	Nef	920	6285	Gene	Gene	cells|compound|START_ENTITY stimulation|nmod|cells Hyper-responsiveness|nmod|stimulation requires|nsubj|Hyper-responsiveness requires|dobj|products products|compound|END_ENTITY	Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4 + T cells requires Nef and Tat virus gene products and results from higher NFAT , NF-kappaB , and AP-1 induction .
15494497	0	CD4	0,3	Nef	39,42	CD4	Nef	920	6285	Gene	Gene	phosphorylation|compound|START_ENTITY reverses|nsubj|phosphorylation reverses|dobj|down-regulation down-regulation|compound|END_ENTITY	CD4 phosphorylation partially reverses Nef down-regulation of CD4 .
15494497	0	CD4	62,65	Nef	39,42	CD4	Nef	920	6285	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|compound|END_ENTITY	CD4 phosphorylation partially reverses Nef down-regulation of CD4 .
15611114	0	CD4	0,3	Nef	69,72	CD4	Nef	920	1490008(Tax:11723)	Gene	Gene	proteins|nummod|START_ENTITY proteins|compound|END_ENTITY	CD4 down-regulation by HIV-1 and simian_immunodeficiency_virus _ -LRB- SIV -RRB- Nef proteins involves both internalization and intracellular retention mechanisms .
16310238	0	CD4	49,52	Nef	6,9	CD4	Nef	12504(Tax:10090)	57783(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY abrogating|dobj|downregulation mutations|acl|abrogating mutations|compound|END_ENTITY	HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic_mice .
16310238	0	CD4	49,52	Nef	66,69	CD4	Nef	12504(Tax:10090)	57783(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY abrogating|dobj|downregulation mutations|acl|abrogating affect|nsubj|mutations affect|ccomp|reduced reduced|nsubj|functions functions|compound|END_ENTITY	HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic_mice .
16979207	0	CD4	0,3	Nef	60,63	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	downregulation|compound|START_ENTITY conserved|nsubjpass|downregulation conserved|nmod|alleles alleles|compound|END_ENTITY	CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues , but Pak2 activation is highly variable .
17346169	0	CD4	14,17	Nef	40,43	CD4	Nef	920	6285	Gene	Gene	Mechanisms|nmod|START_ENTITY downregulation|nsubj|Mechanisms downregulation|nmod|proteins proteins|compound|END_ENTITY	Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses .
17411376	0	CD4	113,116	Nef	45,48	CD4	Nef	920	6285	Gene	Gene	+|compound|START_ENTITY CD8|dep|+ induce|dobj|CD8 induce|nsubj|peptides peptides|acl|identified identified|nmod|protein protein|compound|END_ENTITY	HLA-DR-restricted peptides identified in the Nef protein can induce HIV_type_1-specific IL-2 / IFN-gamma-secreting CD4 + and CD4 + / CD8 + T cells in humans after lipopeptide vaccination .
17600593	0	CD4	31,34	Nef	18,21	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Presence of HIV-1 Nef specific CD4 T cell response is associated with non-progression in HIV-1_infection .
17947540	0	CD4	47,50	Nef	121,124	CD4	Nef	920	6285	Gene	Gene	retention|nmod|START_ENTITY functions|nsubj|retention functions|nmod|protein protein|compound|END_ENTITY	Internalization and intracellular retention of CD4 are two separate functions of the human_immunodeficiency_virus_type_1 Nef protein .
18523251	0	CD4	83,86	Nef	49,52	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	down-regulation|compound|START_ENTITY required|nmod|down-regulation required|nsubjpass|Lysine Lysine|appos|site site|nmod|END_ENTITY	Lysine 144 , a ubiquitin attachment site in HIV-1 Nef , is required for Nef-mediated CD4 down-regulation .
19146681	0	CD4	80,83	Nef	22,25	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	T|compound|START_ENTITY enhancement|nmod|T END_ENTITY|nmod|enhancement	Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4 + T lymphocytes in human lymphoid tissue ex vivo .
19403684	0	CD4	56,59	Nef	36,39	CD4	Nef	920	6285	Gene	Gene	START_ENTITY|nsubj|targets targets|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef protein targets CD4 to the multivesicular body pathway .
19643141	0	CD4	27,30	Nef	59,62	CD4	Nef	920	6285	Gene	Gene	assessment|nmod|START_ENTITY assessment|acl|downregulation downregulation|nmod|primary primary|compound|END_ENTITY	Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection .
19740990	0	CD4	109,112	Nef	135,138	CD4	Nef	12504(Tax:10090)	57783(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY model|dep|T-cell Adult_AIDS-like_disease|nmod|model activation|amod|Adult_AIDS-like_disease END_ENTITY|nsubjpass|activation	Adult_AIDS-like_disease in a novel inducible human_immunodeficiency_virus_type_1 Nef transgenic mouse model : CD4 + T-cell activation is Nef dependent and can occur in the absence_of_lymphophenia .
19740990	0	CD4	109,112	Nef	81,84	CD4	Nef	12504(Tax:10090)	156110(Tax:11676)	Gene	Gene	T-cell|compound|START_ENTITY model|dep|T-cell model|compound|END_ENTITY	Adult_AIDS-like_disease in a novel inducible human_immunodeficiency_virus_type_1 Nef transgenic mouse model : CD4 + T-cell activation is Nef dependent and can occur in the absence_of_lymphophenia .
20881088	0	CD4	0,3	Nef	62,65	CD4	Nef	920	6285	Gene	Gene	downregulation|nummod|START_ENTITY downregulation|nmod|protein protein|compound|END_ENTITY	CD4 downregulation by the human_immunodeficiency_virus_type_1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells .
21543478	0	CD4	90,93	Nef	6,9	CD4	Nef	920	6285	Gene	Gene	CD8|appos|START_ENTITY trafficking|nmod|CD8 disrupts|dobj|trafficking disrupts|nsubj|END_ENTITY	HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I , CD4 , CD8 , and CD28 by distinct pathways that share common elements .
22103832	0	CD4	12,15	Nef	44,47	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	activity|compound|START_ENTITY Role|nmod|activity Role|nmod|END_ENTITY	Role of the CD4 down-modulation activity of Nef in HIV-1 infectivity .
22479639	0	CD4	65,68	Nef	6,9	CD4	Nef	920	6285	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|nsubj|END_ENTITY	HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4 + T cells and promotes T-cell activation .
23151229	0	CD4	121,124	Nef	58,61	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	downregulation|compound|START_ENTITY required|nmod|downregulation Identification|acl|required Identification|nmod|loop loop|compound|END_ENTITY	Identification of a novel binding site between HIV_type_1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation .
24465014	0	CD4	55,58	Nef	4,7	CD4	Nef	920	6285	Gene	Gene	cells|compound|START_ENTITY preservation|nmod|cells favors|dobj|preservation favors|nsubj|expression expression|compound|END_ENTITY	HIV Nef expression favors the relative preservation of CD4 + T regulatory cells that retain some important suppressive functions .
24473078	0	CD4	64,67	Nef	10,13	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	downregulate|dobj|START_ENTITY adaptor|xcomp|downregulate adaptor|csubj|hijacks hijacks|nsubj|END_ENTITY	How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4 .
25118280	0	CD4	92,95	Nef	21,24	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	receptor|compound|START_ENTITY lysosomal|nmod|receptor promotes|dobj|lysosomal promotes|nsubj|Interaction Interaction|nmod|protein protein|compound|END_ENTITY	Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor .
25423108	0	CD4	45,48	Nef	0,3	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	Cells|compound|START_ENTITY Neutralizes|nmod|Cells Neutralizes|nsubj|END_ENTITY	Nef Neutralizes the Ability of Exosomes from CD4 + T Cells to Act as Decoys during HIV-1_Infection .
7769669	0	CD4	20,23	Nef	122,125	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	downregulation|compound|START_ENTITY Dissociation|nmod|downregulation Dissociation|nmod|END_ENTITY	Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human_immunodeficiency_virus_type_1 Nef .
7831289	0	CD4	109,112	Nef	36,39	CD4	Nef	920	6285	Gene	Gene	tail|compound|START_ENTITY element|nmod|tail interact|nmod|element interact|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail .
7871751	0	CD4	36,39	Nef	6,9	CD4	Nef	920	6285	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression downregulation|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
7871751	0	CD4	99,102	Nef	6,9	CD4	Nef	920	6285	Gene	Gene	domain|nmod|START_ENTITY relevance|nmod|domain downregulation|dep|relevance downregulation|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
7902127	0	CD4	19,22	Nef	54,57	CD4	Nef	920	6285	Gene	Gene	molecules|nummod|START_ENTITY molecules|nmod|expression expression|nmod|END_ENTITY	Down-regulation of CD4 molecules by the expression of Nef : a quantitative analysis of CD4 antigens on the cell surfaces .
7902127	0	CD4	86,89	Nef	54,57	CD4	Nef	920	6285	Gene	Gene	antigens|nummod|START_ENTITY analysis|nmod|antigens Down-regulation|dep|analysis Down-regulation|nmod|molecules molecules|nmod|expression expression|nmod|END_ENTITY	Down-regulation of CD4 molecules by the expression of Nef : a quantitative analysis of CD4 antigens on the cell surfaces .
7903128	0	CD4	104,107	Nef	20,23	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	Nef 27 , but not the Nef 25 isoform of human_immunodeficiency_virus-type_1 pNL4 .3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells .
7905875	0	CD4	70,73	Nef	34,37	CD4	Nef	920	1490008(Tax:11723)	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|protein protein|compound|END_ENTITY	The simian_immunodeficiency_virus Nef protein promotes degradation of CD4 in human T cells .
7917514	0	CD4	55,58	Nef	14,17	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY pathways|nmod|cells pathways|nsubj|Role Role|nmod|expression expression|compound|END_ENTITY	Role of HIV-1 Nef expression in activation pathways in CD4 + T cells .
7983750	0	CD4	64,67	Nef	36,39	CD4	Nef	920	6285	Gene	Gene	accumulation|nmod|START_ENTITY induces|dobj|accumulation induces|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef induces accumulation of CD4 in early endosomes .
8098729	0	CD4	31,34	Nef	79,82	CD4	Nef	920	1490008(Tax:11723)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Downregulation of cell-surface CD4 expression by simian_immunodeficiency_virus Nef prevents viral_super_infection .
8102828	0	CD4	98,101	Nef	61,64	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	lymphocytes|compound|START_ENTITY inhibitor|nmod|lymphocytes protein|nmod|inhibitor protein|compound|END_ENTITY	Evidence for the role of human_immunodeficiency_virus_type_1 Nef protein as a growth inhibitor to CD4 + T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies .
8124721	0	CD4	12,15	Nef	0,3	CD4	Nef	920	6285	Gene	Gene	endocytosis|nummod|START_ENTITY induces|dobj|endocytosis induces|nsubj|END_ENTITY	Nef induces CD4 endocytosis : requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain .
8124721	0	CD4	97,100	Nef	0,3	CD4	Nef	920	6285	Gene	Gene	domain|compound|START_ENTITY motif|nmod|domain requirement|nmod|motif endocytosis|dep|requirement induces|dobj|endocytosis induces|nsubj|END_ENTITY	Nef induces CD4 endocytosis : requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain .
8151774	0	CD4	26,29	Nef	129,132	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	domain|nmod|START_ENTITY sufficient|nsubj|domain sufficient|nmod|END_ENTITY	The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human_immunodeficiency_virus_type_1 Nef .
8184546	0	CD4	30,33	Nef	56,59	CD4	Nef	920	6285	Gene	Gene	suppression|nmod|START_ENTITY surface|nsubj|suppression surface|nmod|END_ENTITY	Specific suppression of human CD4 surface expression by Nef from the pathogenic simian_immunodeficiency_virus SIVmac239open .
8262036	0	CD4	0,3	Nef	41,44	CD4	Nef	12504(Tax:10090)	156110(Tax:11676)	Gene	Gene	downregulation|compound|START_ENTITY downregulation|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	CD4 cell surface downregulation in HIV-1 Nef transgenic_mice is a consequence of intracellular sequestration .
8265644	0	CD4	102,105	Nef	63,66	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	line|compound|START_ENTITY cells|nmod|line nucleus|nmod|cells END_ENTITY|nmod|nucleus	Highly localized tracks of human_immunodeficiency_virus_type_1 Nef in the nucleus of cells of a human CD4 + T-cell line .
8331733	0	CD4	84,87	Nef	0,3	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Nef from primary isolates of human immunodeficiency_virus type 1 suppresses surface CD4 expression in human and mouse T cells .
8437228	0	CD4	79,82	Nef	59,62	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	The negative effect of human_immunodeficiency_virus_type_1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4 .
8599214	0	CD4	99,102	Nef	29,32	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	downregulation|compound|START_ENTITY temperature-sensitive|nmod|downregulation mutants|acl:relcl|temperature-sensitive identification|nmod|mutants analysis|dep|identification analysis|nmod|END_ENTITY	Mutational analysis of HIV-1 Nef : identification of two mutants that are temperature-sensitive for CD4 downregulation .
8756680	0	CD4	4,7	Nef	48,51	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	determinant|compound|START_ENTITY determinant|nmod|downregulation downregulation|nmod|END_ENTITY	The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef .
8756680	0	CD4	4,7	Nef	70,73	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	determinant|compound|START_ENTITY binds|nsubj|determinant binds|nmod|END_ENTITY	The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef .
8804432	0	CD4	52,55	Nef	8,11	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY cytotoxic|nmod|cells cytotoxic|nsubj|antigen antigen|compound|END_ENTITY	Soluble Nef antigen of HIV-1 is cytotoxic for human CD4 + T cells .
8804435	0	CD4	91,94	Nef	36,39	CD4	Nef	920	6285	Gene	Gene	cells|compound|START_ENTITY cytocidal|nmod|cells cytocidal|nsubj|protein protein|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef protein on the cell surface is cytocidal for human CD4 + T cells .
8871625	0	CD4	48,51	Nef	139,142	CD4	Nef	920	6285	Gene	Gene	domain|nmod|START_ENTITY analysis|nmod|domain analysis|dep|overlapping overlapping|nmod|END_ENTITY	Molecular analysis of the cytoplasmic domain of CD4 : overlapping but noncompetitive requirement for lck association and down-regulation by Nef .
9032396	0	CD4	91,94	Nef	68,71	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of phosphorylation of human_immunodeficiency_virus_type_1 Nef and enhancement of CD4 downregulation by phorbol_myristate_acetate .
9049297	0	CD4	77,80	Nef	23,26	CD4	Nef	920	6285	Gene	Gene	expression|compound|START_ENTITY machinery|dep|expression aspects|nmod|machinery disrupt|dobj|aspects disrupt|nsubj|functions functions|nmod|END_ENTITY	Separable functions of Nef disrupt two aspects of T cell receptor machinery : CD4 expression and CD3 signaling .
9153233	0	CD4	81,84	Nef	17,20	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	down-regulation|compound|START_ENTITY thioesterase|nmod|down-regulation thioesterase|nsubj|Binding Binding|nmod|END_ENTITY	Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation .
9168885	0	CD4	93,96	Nef	35,38	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	downregulation|nmod|START_ENTITY required|nmod|downregulation required|nsubj|Identification Identification|nmod|regions regions|nmod|END_ENTITY	Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4 .
9384576	0	CD4	95,98	Nef	25,28	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	down-regulation|compound|START_ENTITY correlates|nmod|down-regulation correlates|nsubj|Co-localization Co-localization|nmod|END_ENTITY	Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation .
9473011	0	CD4	79,82	Nef	64,67	CD4	Nef	920	6285	Gene	Gene	downmodulation|compound|START_ENTITY promote|dobj|downmodulation contain|advcl|promote contain|dobj|END_ENTITY	T cells chronically infected with HIV do not contain sufficient Nef to promote CD4 downmodulation in the absence of envelope-mediated effects .
9564030	0	CD4	25,28	Nef	42,45	CD4	Nef	920	6285	Gene	Gene	endocytosis|compound|START_ENTITY Mechanism|nmod|endocytosis Mechanism|dep|CD4 CD4|compound|END_ENTITY	Mechanism of Nef-induced CD4 endocytosis : Nef connects CD4 with the mu chain of adaptor complexes .
9620685	0	CD4	84,87	Nef	26,29	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	internalization|nmod|START_ENTITY facilitate|dobj|internalization facilitate|nsubj|Interactions Interactions|nmod|END_ENTITY	Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4 .
9736718	0	CD4	91,94	Nef	21,24	CD4	Nef	920	156110(Tax:11676)	Gene	Gene	down-regulation|nummod|START_ENTITY required|nmod|down-regulation required|nsubjpass|Interaction Interaction|nmod|END_ENTITY	Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity .
9920849	0	CD4	59,62	Nef	36,39	CD4	Nef	920	6285	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef protein sensitizes CD4 -LRB- + -RRB- T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 _ ligand pathway .
9971776	0	CD4	12,15	Nef	169,172	CD4	Nef	920	6285	Gene	Gene	governed|nsubjpass|START_ENTITY governed|parataxis|alpha alpha|ccomp|regulate regulate|nsubj|repeat repeat|nmod|END_ENTITY	Nef-induced CD4 and major histocompatibility complex class I -LRB- MHC-I -RRB- down-regulation are governed by distinct determinants : N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking .
22250088	0	CD4	37,40	Nrf2	29,33	CD4	Nrf2	920	4780	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Th2 skewing by activation of Nrf2 in CD4 -LRB- + -RRB- T cells .
25484350	0	CD4	68,71	Nrf2	4,8	CD4	Nrf2	920	4780	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells inhibits|dobj|activation inhibits|nsubj|tBHQ tBHQ|amod|END_ENTITY	The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells .
23577203	0	CD4	0,3	Nrp1	13,17	CD4	Nrp1	12504(Tax:10090)	18186(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- Nrp1 -LRB- + -RRB- T cells synergize with rapamycin to prevent murine cardiac allorejection in immunocompetent recipients .
10359115	0	CD4	0,3	OX40	62,66	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	traffic|nummod|START_ENTITY control|nsubj|traffic control|ccomp|leads leads|nsubj|ligation ligation|nmod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	CD4	155,158	OX40	62,66	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY accumulation|nmod|cells leads|nmod|accumulation leads|nsubj|ligation ligation|nmod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	CD4	70,73	OX40	62,66	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10975814	0	CD4	62,65	OX40	4,8	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	memory|compound|START_ENTITY development|nmod|memory determines|dobj|development determines|nsubj|receptor receptor|compound|END_ENTITY	The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion .
11414737	0	CD4	59,62	OX40	0,4	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY turnover|nmod|cells enhances|dobj|turnover enhances|nsubj|ligation ligation|compound|END_ENTITY	OX40 ligation enhances cell cycle turnover of Ag-activated CD4 T cells in vivo .
11739496	0	CD4	45,48	OX40	14,18	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	T|compound|START_ENTITY enhances|dobj|T enhances|nsubj|Engagement Engagement|nmod|END_ENTITY	Engagement of OX40 enhances antigen-specific CD4 -LRB- + -RRB- T cell mobilization/memory development and humoral immunity : comparison of alphaOX-40 with alphaCTLA-4 .
12460238	0	CD4	134,137	OX40	128,132	CD4	OX40	920	7293	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Myasthenia_gravis after allogeneic bone marrow transplantation treated with mycophenolate_mofetil monitored by peripheral blood OX40 + CD4 + T cells .
12753741	0	CD4	0,3	OX40	68,72	CD4	OX40	920	7293	Gene	Gene	CD3|compound|START_ENTITY primed|nsubj|CD3 primed|nmod|END_ENTITY	CD4 -LRB- + -RRB- CD3 -LRB- - -RRB- accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells .
12753741	0	CD4	48,51	OX40	68,72	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY primed|dobj|cells primed|nmod|END_ENTITY	CD4 -LRB- + -RRB- CD3 -LRB- - -RRB- accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells .
15591118	0	CD4	30,33	OX40	112,116	CD4	OX40	920	7293	Gene	Gene	CD25|compound|START_ENTITY OX40|nmod|CD25 Triggering|nmod|OX40 blocks|dep|Triggering blocks|dobj|activity activity|dep|role role|nmod|END_ENTITY	Triggering of OX40 -LRB- CD134 -RRB- on CD4 -LRB- + -RRB- CD25 + T cells blocks their inhibitory activity : a novel regulatory role for OX40 and its comparison with GITR .
15591118	0	CD4	30,33	OX40	14,18	CD4	OX40	920	7293	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Triggering of OX40 -LRB- CD134 -RRB- on CD4 -LRB- + -RRB- CD25 + T cells blocks their inhibitory activity : a novel regulatory role for OX40 and its comparison with GITR .
15778343	0	CD4	92,95	OX40	18,22	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	memory|compound|START_ENTITY responses|nmod|memory signals|dobj|responses signals|nsubj|deficient deficient|nmod|END_ENTITY	Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory .
16176850	0	CD4	14,17	OX40	35,39	CD4	OX40	920	7293	Gene	Gene	Regulation|nmod|START_ENTITY T|nsubj|Regulation T|nmod|END_ENTITY	Regulation of CD4 T cell memory by OX40 -LRB- CD134 -RRB- .
16367941	0	CD4	30,33	OX40	14,18	CD4	OX40	920	7293	Gene	Gene	T-cells|compound|START_ENTITY Expression|nmod|T-cells Expression|nmod|END_ENTITY	Expression of OX40 -LRB- CD134 -RRB- on CD4 + T-cells from patients with myasthenia_gravis .
16456009	0	CD4	17,20	OX40	0,4	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY ligation|nmod|cells ligation|nummod|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16541471	0	CD4	50,53	OX40	0,4	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells engagement|dobj|differentiation engagement|nsubj|END_ENTITY	OX40 -LRB- CD134 -RRB- engagement drives differentiation of CD4 + T cells to effector cells .
17429847	0	CD4	20,23	OX40	79,83	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY Cooperation|nmod|cells enhanced|nsubjpass|Cooperation enhanced|nmod|signals signals|nummod|END_ENTITY	Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals .
17584577	0	CD4	77,80	OX40	46,50	CD4	OX40	920	7293	Gene	Gene	+|compound|START_ENTITY ligand|nmod|+ ligand|nsubj|Requirements Requirements|nmod|expression expression|nmod|END_ENTITY	Requirements for the functional expression of OX40 ligand on human activated CD4 + and CD8 + T cells .
17641007	0	CD4	77,80	OX40	14,18	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY conversion|nmod|cells inhibits|dobj|conversion inhibits|nsubj|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17911586	0	CD4	88,91	OX40	30,34	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generation|nmod|cells signals|nmod|generation signals|nsubj|requirements requirements|nmod|END_ENTITY	Differential requirements for OX40 signals on generation of effector and central memory CD4 + T cells .
18275893	0	CD4	41,44	OX40	46,50	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Growth and differentiation advantages of CD4 + OX40 + T cells from allogeneic hematopoietic stem cell transplantation recipients .
19635903	0	CD4	38,41	OX40	126,130	CD4	OX40	920	7293	Gene	Gene	cells|compound|START_ENTITY levels|nmod|cells revealed|nsubj|levels revealed|nmod|coexpression coexpression|nmod|CD25 CD25|appos|END_ENTITY	High levels of human antigen-specific CD4 + T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 -LRB- OX40 -RRB- .
19786532	0	CD4	23,26	OX40	75,79	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY survival|nmod|cells requires|nsubj|survival requires|dobj|signals signals|compound|END_ENTITY	The survival of memory CD4 + T cells within the gut lamina propria requires OX40 and CD30 signals .
20019337	0	CD4	26,29	OX40	7,11	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY engagement|nmod|cells cells|amod|engagement cells|nummod|END_ENTITY	Serial OX40 engagement on CD4 + T cells and natural killer T cells causes allergic_airway_inflammation .
22017436	0	CD4	134,137	OX40	0,4	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	memory|compound|START_ENTITY maintaining|dobj|memory cells|acl|maintaining role|nmod|cells signals|dep|role signals|compound|END_ENTITY	OX40 and CD30 signals in CD4 -LRB- + -RRB- T-cell effector and memory function : a distinct role for lymphoid tissue inducer cells in maintaining CD4 -LRB- + -RRB- T-cell memory but not effector function .
22017436	0	CD4	25,28	OX40	0,4	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	effector|amod|START_ENTITY signals|nmod|effector signals|compound|END_ENTITY	OX40 and CD30 signals in CD4 -LRB- + -RRB- T-cell effector and memory function : a distinct role for lymphoid tissue inducer cells in maintaining CD4 -LRB- + -RRB- T-cell memory but not effector function .
22754764	0	CD4	112,115	OX40	0,4	CD4	OX40	920	7293	Gene	Gene	T|compound|START_ENTITY induced|nmod|T CD28|acl|induced abrogates|dobj|CD28 abrogates|nsubj|costimulation costimulation|nummod|END_ENTITY	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
24468748	0	CD4	13,16	OX40	101,105	CD4	OX40	920	7293	Gene	Gene	sensitizes|compound|START_ENTITY melanomas|nsubj|sensitizes melanomas|xcomp|immunotherapy immunotherapy|nmod|agonist agonist|compound|END_ENTITY	Intratumoral CD4 + T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist .
24771127	0	CD4	23,26	OX40	0,4	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY effector|dobj|expansion controls|ccomp|effector controls|nsubj|END_ENTITY	OX40 controls effector CD4 + T-cell expansion , not follicular T helper cell generation in acute Listeria_infection .
24797972	0	CD4	63,66	OX40	19,23	CD4	OX40	920	7293	Gene	Gene	cells|amod|START_ENTITY molecules|nmod|cells molecules|nsubj|expression expression|nmod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
25103720	0	CD4	89,92	OX40	0,4	CD4	OX40	12504(Tax:10090)	22163(Tax:10090)	Gene	Gene	proliferation|nmod|START_ENTITY roles|nmod|proliferation T|nsubj|roles play|ccomp|T play|nsubj|END_ENTITY	OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4 -LRB- + -RRB- T cells .
10359115	0	CD4	0,3	OX40-ligand	85,96	CD4	OX40-ligand	12504(Tax:10090)	22164(Tax:10090)	Gene	Gene	traffic|nummod|START_ENTITY control|nsubj|traffic control|ccomp|leads leads|nsubj|ligation ligation|nmod|OX40 OX40|nmod|cells cells|nmod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	CD4	155,158	OX40-ligand	85,96	CD4	OX40-ligand	12504(Tax:10090)	22164(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY accumulation|nmod|cells leads|nmod|accumulation leads|nsubj|ligation ligation|nmod|OX40 OX40|nmod|cells cells|nmod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	CD4	70,73	OX40-ligand	85,96	CD4	OX40-ligand	12504(Tax:10090)	22164(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
26481684	0	CD4	44,47	Oct1	0,4	CD4	Oct1	920	5451	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|END_ENTITY	Oct1 and OCA-B are selectively required for CD4 memory T cell function .
12714803	0	CD4	121,124	P-glycoprotein	52,66	CD4	P-glycoprotein	920	5243	Gene	Gene	line|compound|START_ENTITY variants|nmod|line protease|nmod|variants protease|nmod|function function|amod|END_ENTITY	Differential effect of HIV-1 protease inhibitors on P-glycoprotein function in multidrug-resistant variants of the human CD4 + T_lymphoblastoid_CEM cell line .
14525546	0	CD4	105,108	P-glycoprotein	81,95	CD4	P-glycoprotein	920	5243	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells .
15201669	0	CD4	40,43	P-glycoprotein	0,14	CD4	P-glycoprotein	920	5243	Gene	Gene	+|compound|START_ENTITY decreased|nmod|+ decreased|nsubjpass|activity activity|amod|END_ENTITY	P-glycoprotein activity is decreased in CD4 + but not CD8 + lung allograft-infiltrating T cells during acute cellular rejection .
17890284	0	CD4	141,144	P-glycoprotein	14,28	CD4	P-glycoprotein	920	5243	Gene	Gene	cells|compound|START_ENTITY lopinavir|nmod|cells concentration|nmod|lopinavir modulates|dobj|concentration modulates|nsubj|Inhibition Inhibition|nmod|proteins proteins|amod|END_ENTITY	Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes .
18451510	0	CD4	45,48	P-glycoprotein	0,14	CD4	P-glycoprotein	920	5243	Gene	Gene	cells|compound|START_ENTITY functions|nmod|cells functions|amod|END_ENTITY	P-glycoprotein functions in peripheral-blood CD4 + cells of patients with systemic_lupus_erythematosus .
19748977	0	CD4	109,112	P-glycoprotein	73,87	CD4	P-glycoprotein	920	5243	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes .
15570170	0	CD4	70,73	PACAP	31,36	CD4	PACAP	12504(Tax:10090)	11516(Tax:10090)	Gene	Gene	T-lymphocytes|compound|START_ENTITY END_ENTITY|nmod|T-lymphocytes	Restoration of axotomy-induced PACAP gene induction in SCID mice with CD4 + T-lymphocytes .
17075267	0	CD4	16,19	PAR-2	0,5	CD4	PAR-2	12504(Tax:10090)	109447(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
23324275	0	CD4	38,41	PD-1	52,56	CD4	PD-1	920	5133	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Frequency of T-cell FoxP3 Treg and CD4 / CD8 PD-1 expression is related to HBeAg seroconversion in hepatitis_B patients on pegylated interferon .
25968455	0	CD4	23,26	PD-1	46,50	CD4	PD-1	920	5133	Gene	Gene	cells|compound|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	Pre-existing levels of CD4 T cells expressing PD-1 are related to overall survival in prostate_cancer patients treated with ipilimumab .
17924994	0	CD4	74,77	PD-L1	22,27	CD4	PD-L1	920	29126	Gene	Gene	cells|nsubj|START_ENTITY regulating|xcomp|cells dichotomy|acl|regulating dichotomy|nmod|pathways pathways|compound|END_ENTITY	Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells in vivo .
19229109	0	CD4	27,30	PD-L1	0,5	CD4	PD-L1	920	29126	Gene	Gene	Tregs|nummod|START_ENTITY regulates|dobj|Tregs regulates|nsubj|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
22322668	0	CD4	79,82	PD-L1	118,123	CD4	PD-L1	920	29126	Gene	Gene	functional|dep|START_ENTITY Foxp3|amod|functional Foxp3|dep|END_ENTITY	Immune suppression in premalignant respiratory_papillomas : enriched functional CD4 + Foxp3 + regulatory T cells and PD-1 / PD-L1 / L2 expression .
23734334	0	CD4	83,86	PD-L1	32,37	CD4	PD-L1	920	29126	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4 -LRB- + -RRB- T cells .
25630305	0	CD4	24,27	PD-L1	58,63	CD4	PD-L1	12504(Tax:10090)	60533(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY control|nmod|T-cell subsets|nsubj|control subsets|dep|axis axis|compound|END_ENTITY	Differential control of CD4 -LRB- + -RRB- T-cell subsets by the PD-1 / PD-L1 axis in a mouse model of allergic_asthma .
26116499	0	CD4	0,3	PD-L1	68,73	CD4	PD-L1	920	29126	Gene	Gene	Substantially|compound|START_ENTITY Augments|nsubj|Substantially Augments|dobj|Potential Potential|nmod|Blockade Blockade|compound|END_ENTITY	CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells .
26166019	0	CD4	36,39	PD-L1	27,32	CD4	PD-L1	920	29126	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26266813	0	CD4	23,26	PD-L1	14,19	CD4	PD-L1	920	29126	Gene	Gene	Foxp3|compound|START_ENTITY END_ENTITY|nmod|Foxp3	Expression of PD-L1 on CD4 + CD25 + Foxp3 + Regulatory T Cells of Patients with Chronic_HBV_Infection and Its Correlation with Clinical Parameters .
26615520	0	CD4	76,79	PD-L1	121,126	CD4	PD-L1	920	29126	Gene	Gene	CD25|compound|START_ENTITY activation|nmod|CD25 activation|nmod|cells cells|dep|END_ENTITY	Human umbilical vein endothelial cells promote the inhibitory activation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via PD-L1 .
24434439	0	CD4	79,82	PDCD4	59,64	CD4	PDCD4	920	27250	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Effect of intensive atorvastatin therapy on periprocedural PDCD4 expression in CD4 + T lymphocytes of patients with unstable_angina undergoing percutaneous coronary intervention .
22905034	0	CD4	42,45	PI3K	16,20	CD4	PI3K	920	5293	Gene	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	The Role of the PI3K Signaling Pathway in CD4 -LRB- + -RRB- T Cell Differentiation and Function .
7528357	0	CD4	20,23	PLP	75,78	CD4	PLP	12504(Tax:10090)	18823(Tax:10090)	Gene	Gene	+|compound|START_ENTITY specificity|nmod|+ T|nsubj|specificity T|nmod|peptide peptide|compound|END_ENTITY	Fine specificity of CD4 + T cell responses to the dominant encephalitogenic PLP 139-151 peptide in SJL/J mice .
7543908	0	CD4	91,94	PLP	70,73	CD4	PLP	920	5354	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Differential recognition of peptide analogs by naive verses activated PLP 139-151-specific CD4 + T cells .
20038602	0	CD4	20,23	PLZF	14,18	CD4	PLZF	920	7704	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Generation of PLZF + CD4 + T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans .
23776174	0	CD4	67,70	PLZF	54,58	CD4	PLZF	12504(Tax:10090)	235320(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	A transgenic TCR directs the development of IL-4 + and PLZF + innate CD4 T cells .
26052961	0	CD4	47,50	PROGRAMMED_DEATH_1	14,32	CD4	PROGRAMMED DEATH 1	404704(Tax:9823)	5133	Gene	Gene	CELLS|compound|START_ENTITY EXPRESSION|nmod|CELLS EXPRESSION|compound|END_ENTITY	PERIOPERATIVE PROGRAMMED_DEATH_1 EXPRESSION ON CD4 + T CELLS PREDICTS THE INCIDENCE OF POSTOPERATIVE INFECTIOUS COMPLICATIONS .
20049450	0	CD4	18,21	Perforin	0,8	CD4	Perforin	920	5551	Gene	Gene	level|nmod|START_ENTITY level|compound|END_ENTITY	Perforin level in CD4 + T cells from patients with systemic_lupus_erythematosus .
15728475	0	CD4	43,46	Platelet_factor_4	0,17	CD4	Platelet factor 4	920	5196	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	CD4	73,76	Platelet_factor_4	0,17	CD4	Platelet factor 4	920	5196	Gene	Gene	CD25|compound|START_ENTITY +|nmod|CD25 END_ENTITY|nsubj|+	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
25803808	0	CD4	46,49	Programmed_Death_1	0,18	CD4	Programmed Death 1	404704(Tax:9823)	18566(Tax:10090)	Gene	Gene	Accumulation|compound|START_ENTITY Memory|dobj|Accumulation Memory|nsubj|Regulates Regulates|compound|END_ENTITY	Programmed_Death_1 Regulates Memory Phenotype CD4 T Cell Accumulation , Inhibits Expansion of the Effector Memory Phenotype Subset and Modulates Production of Effector Cytokines .
22159143	0	CD4	25,28	Prolactin	0,9	CD4	Prolactin	920	5617	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Prolactin down-regulates CD4 + CD25hiCD127low / - regulatory T cell function in humans .
21453726	0	CD4	37,40	RANKL	17,22	CD4	RANKL	920	8600	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
10975998	0	CD4	61,64	RANTES	20,26	CD4	RANTES	920	6352	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Modulatory roles of RANTES in IL-4 production by human blood CD4 -LRB- + -RRB- T cells .
11314865	0	CD4	61,64	RANTES	28,34	CD4	RANTES	920	6352	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression and secretion of RANTES by human peripheral blood CD4 + cells are dependent on the presence of monocytes .
11343219	0	CD4	23,26	RANTES	0,6	CD4	RANTES	920	6352	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|compound|END_ENTITY	RANTES production from CD4 + lymphocytes correlates with host genotype and rates of human_immunodeficiency_virus_type_1 disease progression .
7525718	0	CD4	26,29	RANTES	139,145	CD4	RANTES	920	6352	Gene	Gene	T|compound|START_ENTITY adhesion|nmod|T Regulation|nmod|adhesion lymphocytes|nsubj|Regulation lymphocytes|nmod|END_ENTITY	Regulation of adhesion of CD4 + T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1_beta .
26285214	0	CD4	36,39	RELM-b	20,26	CD4	RELM-b	12504(Tax:10090)	57263(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Goblet Cell Derived RELM-b Recruits CD4 + T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation .
26285214	0	CD4	36,39	RELM-b	20,26	CD4	RELM-b	12504(Tax:10090)	57263(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Goblet Cell Derived RELM-b Recruits CD4 + T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation .
22972397	0	CD4	44,47	SAMHD1	0,6	CD4	SAMHD1	920	25939	Gene	Gene	T|compound|START_ENTITY HIV-1_infection|nmod|T cells|amod|HIV-1_infection restricts|dobj|cells restricts|nsubj|END_ENTITY	SAMHD1 restricts HIV-1_infection in resting CD4 -LRB- + -RRB- T cells .
22972397	0	CD4	44,47	SAMHD1	0,6	CD4	SAMHD1	920	25939	Gene	Gene	T|compound|START_ENTITY HIV-1_infection|nmod|T cells|amod|HIV-1_infection restricts|dobj|cells restricts|nsubj|END_ENTITY	SAMHD1 restricts HIV-1_infection in resting CD4 -LRB- + -RRB- T cells .
23092122	0	CD4	58,61	SAMHD1	0,6	CD4	SAMHD1	920	25939	Gene	Gene	T-cells|compound|START_ENTITY reverse|nmod|T-cells restricts|ccomp|reverse restricts|nsubj|END_ENTITY	SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4 -LRB- + -RRB- T-cells .
23092122	0	CD4	58,61	SAMHD1	0,6	CD4	SAMHD1	920	25939	Gene	Gene	T-cells|compound|START_ENTITY reverse|nmod|T-cells restricts|ccomp|reverse restricts|nsubj|END_ENTITY	SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4 -LRB- + -RRB- T-cells .
23426363	0	CD4	63,66	SAMHD1	31,37	CD4	SAMHD1	920	25939	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Promoter methylation regulates SAMHD1 gene expression in human CD4 + T cells .
23426363	0	CD4	63,66	SAMHD1	31,37	CD4	SAMHD1	920	25939	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Promoter methylation regulates SAMHD1 gene expression in human CD4 + T cells .
25715102	0	CD4	76,79	SAMHD1	4,10	CD4	SAMHD1	920	25939	Gene	Gene	cells|compound|START_ENTITY susceptible|nsubj|cells renders|xcomp|susceptible renders|nsubj|expression expression|compound|END_ENTITY	Low SAMHD1 expression following T-cell activation and proliferation renders CD4 + T cells susceptible to HIV-1 .
25996507	0	CD4	109,112	SAMHD1	99,105	CD4	SAMHD1	713807(Tax:9544)	709060(Tax:9544)	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus_Macaques Suppresses SAMHD1 in CD4 + Memory T Cells .
11544290	0	CD4	143,146	SDF-1	134,139	CD4	SDF-1	920	6387	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Diverse transcriptional response of CD4 + T cells to stromal cell-derived factor SDF-1 : cell survival promotion and priming effects of SDF-1 on CD4 + T cells .
11544290	0	CD4	36,39	SDF-1	80,85	CD4	SDF-1	920	6387	Gene	Gene	cells|compound|START_ENTITY cells|acl|stromal stromal|dobj|END_ENTITY	Diverse transcriptional response of CD4 + T cells to stromal cell-derived factor SDF-1 : cell survival promotion and priming effects of SDF-1 on CD4 + T cells .
24088816	0	CD4	26,29	SHP-2	8,13	CD4	SHP-2	12504(Tax:10090)	19247(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|compound|END_ENTITY	Loss of SHP-2 activity in CD4 + T cells promotes melanoma progression and metastasis .
17621372	0	CD4	30,33	SOCS3	10,15	CD4	SOCS3	920	9021	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17186289	0	CD4	14,17	SSX-1	58,63	CD4	SSX-1	920	6756	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Assessment of CD4 + T cells specific for the tumor antigen SSX-1 in cancer-free individuals .
14699080	0	CD4	24,27	STAT1	72,77	CD4	STAT1	12504(Tax:10090)	20846(Tax:10090)	Gene	Gene	+|compound|START_ENTITY development|nmod|+ cells|dep|development cells|nmod|absence absence|nmod|END_ENTITY	Impaired development of CD4 + CD25 + regulatory T cells in the absence of STAT1 : increased susceptibility to autoimmune_disease .
21115047	0	CD4	69,72	STAT1	109,114	CD4	STAT1	920	6772	Gene	Gene	cells|compound|START_ENTITY cells|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	IL-27 induces the differentiation of Tr1-like cells from human naive CD4 + T cells via the phosphorylation of STAT1 and STAT3 .
22496215	0	CD4	63,66	STAT1	18,23	CD4	STAT1	920	6772	Gene	Gene	disease|compound|START_ENTITY develop|dobj|disease develop|nsubj|deficient deficient|nmod|END_ENTITY	Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4 + T-cell-mediated disease following infection with lymphocytic_choriomeningitis_virus .
25261409	0	CD4	55,58	STAT1	111,116	CD4	STAT1	920	6772	Gene	Gene	cells|compound|START_ENTITY sensitizes|dobj|cells sensitizes|nmod|apoptosis apoptosis|nmod|activation activation|nmod|END_ENTITY	Epigallocatechin-3-gallate sensitizes IFN-y-stimulated CD4 + T cells to apoptosis via alternative activation of STAT1 .
26170288	0	CD4	55,58	STAT1	18,23	CD4	STAT1	920	6772	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells function|nsubj|roles roles|nmod|END_ENTITY	Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 + T cells .
17697673	0	CD4	53,56	STAT3	12,17	CD4	STAT3	12504(Tax:10090)	20848(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY END_ENTITY|nmod|Foxp3	The role of STAT3 in antigen-IgG inducing regulatory CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells .
18025205	0	CD4	17,20	STAT3	8,13	CD4	STAT3	12504(Tax:10090)	20848(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18424728	0	CD4	17,20	STAT3	8,13	CD4	STAT3	12504(Tax:10090)	20848(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Loss of STAT3 in CD4 + T cells prevents development of experimental autoimmune_diseases .
19648026	0	CD4	9,12	STAT3	0,5	CD4	STAT3	920	6774	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	STAT3 in CD4 + T helper cell differentiation and inflammatory diseases .
19995899	0	CD4	19,22	STAT3	0,5	CD4	STAT3	12504(Tax:10090)	20848(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	STAT3 signaling in CD4 + T cells is critical for the pathogenesis of chronic_sclerodermatous_graft-versus-host_disease in a murine model .
21085192	0	CD4	26,29	STAT3	55,60	CD4	STAT3	920	6774	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells regulated|nsubjpass|expression regulated|nmod|END_ENTITY	MicroRNA-21 expression in CD4 + T cells is regulated by STAT3 and is pathologically involved in S zary syndrome .
21453726	0	CD4	37,40	STAT3	66,71	CD4	STAT3	920	6774	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells suppresses|dobj|expression suppresses|nmod|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
22532634	0	CD4	2,5	STAT3	93,98	CD4	STAT3	920	6774	Gene	Gene	signature|compound|START_ENTITY implicates|nsubj|signature implicates|dobj|signalling signalling|compound|END_ENTITY	A CD4 T cell gene signature for early rheumatoid_arthritis implicates interleukin_6-mediated STAT3 signalling , particularly in anti-citrullinated peptide antibody-negative disease .
23923047	0	CD4	61,64	STAT3	0,5	CD4	STAT3	920	6774	Gene	Gene	cells|compound|START_ENTITY differentiation|dep|cells induces|dobj|differentiation induces|nsubj|signaling signaling|compound|END_ENTITY	STAT3 signaling induces the differentiation of human ICOS -LRB- + -RRB- CD4 T cells helping B lymphocytes .
24816405	0	CD4	8,11	STAT3	62,67	CD4	STAT3	920	6774	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|promote promote|dobj|stemness stemness|nmod|activation activation|compound|END_ENTITY	IL-22 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells promote colorectal_cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L .
25663681	0	CD4	0,3	STAT3	12,17	CD4	STAT3	920	6774	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	CD4 + T cell STAT3 phosphorylation precedes acute GVHD , and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response .
25880754	0	CD4	0,3	STAT3	65,70	CD4	STAT3	920	6774	Gene	Gene	T-cell|compound|START_ENTITY transcriptome|nsubj|T-cell transcriptome|ccomp|reveals reveals|dobj|regulation regulation|nmod|END_ENTITY	CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid_arthritis : evidence from a case-control study .
25880754	0	CD4	0,3	STAT3	65,70	CD4	STAT3	920	6774	Gene	Gene	T-cell|compound|START_ENTITY transcriptome|nsubj|T-cell transcriptome|ccomp|reveals reveals|dobj|regulation regulation|nmod|END_ENTITY	CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid_arthritis : evidence from a case-control study .
26353115	0	CD4	50,53	STAT3	13,18	CD4	STAT3	920	6774	Gene	Gene	Associates|compound|START_ENTITY Phosphorylation|nmod|Associates Phosphorylation|compound|END_ENTITY	Constitutive STAT3 Phosphorylation in Circulating CD4 + T Lymphocytes Associates with Disease Activity and Treatment Response in Recent-Onset Rheumatoid_Arthritis .
22993203	0	CD4	75,78	STAT5	32,37	CD4	STAT5	12504(Tax:10090)	20850(Tax:10090)	Gene	Gene	T|compound|START_ENTITY activating|nmod|T activating|dobj|production production|compound|END_ENTITY	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
24500400	0	CD4	41,44	STAT5	57,62	CD4	STAT5	920	6776	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
12612581	0	CD4	33,36	Scurfin	22,29	CD4	Scurfin	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	An essential role for Scurfin in CD4 + CD25 + T regulatory cells .
12874208	0	CD4	84,87	Scurfin	0,7	CD4	Scurfin	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	function|compound|START_ENTITY regulation|nmod|function controls|nmod|regulation controls|nsubj|END_ENTITY	Scurfin -LRB- FoxP3 -RRB- controls T-dependent immune responses in vivo through regulation of CD4 + T cell effector function .
20416181	0	CD4	71,74	Sphingosine_1-phosphate_receptor_1	22,56	CD4	Sphingosine 1-phosphate receptor 1	920	1901	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	-LSB- Impact of rhG-CSF on Sphingosine_1-phosphate_receptor_1 expression in CD4 + T cells of donor peripheral blood -RSB- .
21670504	0	CD4	26,29	Stat1	11,16	CD4	Stat1	12504(Tax:10090)	20846(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Absence of Stat1 in donor CD4 T cells promotes the expansion of Tregs and reduces graft-versus-host_disease in mice .
27022145	0	CD4	23,26	Stat3	75,80	CD4	Stat3	920	6774	Gene	Gene	naive|dep|START_ENTITY fate|amod|naive regulates|dobj|fate regulates|nmod|stabilization stabilization|nmod|mRNA mRNA|amod|END_ENTITY	Arid5a regulates naive CD4 + T cell fate through selective stabilization of Stat3 mRNA .
10549628	0	CD4	13,16	Stat6	100,105	CD4	Stat6	920	6778	Gene	Gene	T|compound|START_ENTITY T|dep|END_ENTITY	Autoreactive CD4 + T cells protect from autoimmune diabetes via bystander suppression using the IL-4 / Stat6 pathway .
19698128	0	CD4	71,74	T-Bet	51,56	CD4	T-Bet	920	30009	Gene	Gene	cells|nummod|START_ENTITY Modulation|nmod|cells Modulation|appos|END_ENTITY	Modulation of cytokines and transcription factors -LRB- T-Bet and GATA3 -RRB- in CD4 enriched cervical cells of Chlamydia_trachomatis infected fertile and infertile women upon stimulation with chlamydial inclusion membrane proteins B and C. BACKGROUND : Chlamydial Inclusion membrane proteins -LRB- Incs -RRB- , are involved in biochemical interactions with host cells and infecting Chlamydiae .
24778280	0	CD4	0,3	T-Bet	61,66	CD4	T-Bet	920	30009	Gene	Gene	cells|compound|START_ENTITY require|nsubj|cells require|dobj|PI3K PI3K|acl|signaling signaling|xcomp|increase increase|dobj|expression expression|amod|END_ENTITY	CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy .
11786644	0	CD4	80,83	T-bet	20,25	CD4	T-bet	920	30009	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells lineage|dobj|production lineage|nsubj|effects effects|nmod|END_ENTITY	Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells .
16014561	0	CD4	46,49	T-bet	0,5	CD4	T-bet	920	30009	Gene	Gene	trafficking|compound|START_ENTITY required|nmod|trafficking required|nsubjpass|END_ENTITY	T-bet is required for optimal proinflammatory CD4 + T-cell trafficking .
16177105	0	CD4	23,26	T-bet	14,19	CD4	T-bet	12504(Tax:10090)	57765(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of T-bet by CD4 T cells is essential for resistance to Salmonella_infection .
16861655	0	CD4	49,52	T-bet	29,34	CD4	T-bet	12504(Tax:10090)	57765(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Role of transcription factor T-bet expression by CD4 + cells in gastritis due to Helicobacter_pylori in mice .
18414429	0	CD4	23,26	T-bet	103,108	CD4	T-bet	920	30009	Gene	Gene	response|compound|START_ENTITY modulate|dobj|response modulate|nmod|alterations alterations|nmod|expression expression|nmod|END_ENTITY	Prolactin can modulate CD4 + T-cell response through receptor-mediated alterations in the expression of T-bet .
19414771	0	CD4	64,67	T-bet	0,5	CD4	T-bet	12504(Tax:10090)	57765(Tax:10090)	Gene	Gene	Th17|compound|START_ENTITY differentiation|nmod|Th17 in|dep|differentiation cells|amod|in inhibits|dobj|cells inhibits|nsubj|END_ENTITY	T-bet inhibits the in vivo differentiation of parasite-specific CD4 + Th17 cells in a T cell-intrinsic manner .
19923468	0	CD4	121,124	T-bet	95,100	CD4	T-bet	920	30009	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4 + T cells .
21177324	0	CD4	0,3	T-bet	4,9	CD4	T-bet	920	30009	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + T-bet + , CD4 + pSTAT3 + and CD8 + T-bet + T cells accumulate in peripheral blood during NZB treatment .
21690296	0	CD4	82,85	T-bet	47,52	CD4	T-bet	12504(Tax:10090)	57765(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY regulates|dobj|T-cell regulates|nsubj|phosphorylation phosphorylation|nmod|domain domain|compound|END_ENTITY	c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4 + T-cell differentiation and allergic_lung_inflammation .
23509355	0	CD4	43,46	T-bet	8,13	CD4	T-bet	920	30009	Gene	Gene	dominance|nmod|START_ENTITY dominance|amod|END_ENTITY	Altered T-bet dominance in IFN-y-decoupled CD4 + T cells with attenuated cytokine storm and preserved memory in influenza .
25378399	0	CD4	29,32	T-bet	74,79	CD4	T-bet	920	30009	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Human Memory , but Not Naive , CD4 + T Cells Expressing Transcription Factor T-bet Might Drive Rapid Cytokine Production .
25495780	0	CD4	88,91	T-bet	13,18	CD4	T-bet	920	30009	Gene	Gene	CD25|compound|START_ENTITY Mart-127-35|dep|CD25 cells|amod|Mart-127-35 expression|nmod|cells expression|amod|END_ENTITY	Knockdown of T-bet expression in Mart-127-35 - specific T-cell-receptor-engineered human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- and CD8 -LRB- + -RRB- T cells attenuates effector function .
27021296	0	CD4	27,30	T-bet	5,10	CD4	T-bet	12504(Tax:10090)	57765(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
8367485	0	CD4	68,71	T-cell_receptor	37,52	CD4	T-cell receptor	920	6962	Gene	Gene	T-cell|compound|START_ENTITY usage|nmod|T-cell usage|amod|END_ENTITY	In vivo clonal dominance and limited T-cell_receptor usage in human CD4 + T-cell recognition of house dust mite allergens .
8687197	0	CD4	83,86	T-lymphotropic_virus_type_I-associated_myelopathy_and_tax	6,63	CD4	T-lymphotropic virus type I-associated myelopathy and tax	920	6900	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|amod|END_ENTITY	Human T-lymphotropic_virus_type_I-associated_myelopathy_and_tax gene expression in CD4 + T lymphocytes .
10569764	0	CD4	20,23	TCR	63,66	CD4	TCR	920	6962	Gene	Gene	Regulation|nmod|START_ENTITY alphabeta|nsubj|Regulation alphabeta|dobj|T-cell-receptor-positive T-cell-receptor-positive|dep|END_ENTITY	Regulation of human CD4 -LRB- + -RRB- alphabeta T-cell-receptor-positive -LRB- TCR -LRB- + -RRB- -RRB- and gammadelta TCR -LRB- + -RRB- T-cell responses to Mycobacterium_tuberculosis by interleukin-10 and transforming growth factor beta .
11017105	0	CD4	0,3	TCR	64,67	CD4	TCR	920	6962	Gene	Gene	survival|compound|START_ENTITY linked|nsubjpass|survival linked|nmod|signaling signaling|compound|END_ENTITY	CD4 + T cell survival is not directly linked to self-MHC-induced TCR signaling .
12538680	0	CD4	34,37	TCR	0,3	CD4	TCR	920	6962	Gene	Gene	activation|compound|START_ENTITY principle|nmod|activation reserve|dep|principle reserve|compound|END_ENTITY	TCR reserve : a novel principle of CD4 T cell activation by weak ligands .
12694059	0	CD4	42,45	TCR	47,50	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY mouse|compound|END_ENTITY	Allograft rejection in a new allospecific CD4 + TCR transgenic mouse .
15322166	0	CD4	143,146	TCR	19,22	CD4	TCR	920	6962	Gene	Gene	cells|compound|START_ENTITY required|nmod|cells required|nsubjpass|END_ENTITY	Strong and durable TCR clustering at the T/dendritic cell immune synapse is not required for NFAT activation and IFN-gamma production in human CD4 + T cells .
15379980	0	CD4	25,28	TCR	79,82	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	clones|compound|START_ENTITY clones|nmod|T-cell_receptor T-cell_receptor|appos|END_ENTITY	Differential analysis of CD4 + Th memory clones with identical T-cell_receptor -LRB- TCR -RRB- - alphabeta rearrangement -LRB- non-transgenic -RRB- , but distinct lymphokine phenotype , reveals diverse and novel gene expression .
15496961	0	CD4	18,21	TCR	95,98	CD4	TCR	920	6962	Gene	Gene	lymphocytes|compound|START_ENTITY Redirecting|dobj|lymphocytes requires|dep|Redirecting requires|nmod|transfer transfer|compound|END_ENTITY	Redirecting human CD4 + T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha .
16236130	0	CD4	103,106	TCR	68,71	CD4	TCR	920	6962	Gene	Gene	homeostasis|compound|START_ENTITY regulates|dobj|homeostasis regulates|nsubj|frequency frequency|nmod|thymocytes thymocytes|acl|expressing expressing|dobj|clonotype clonotype|compound|END_ENTITY	The frequency of double-positive thymocytes expressing an alphabeta TCR clonotype regulates peripheral CD4 T cell compartment homeostasis .
16493062	0	CD4	107,110	TCR	92,95	CD4	TCR	920	6962	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Clonal competition inhibits the proliferation and differentiation of adoptively transferred TCR transgenic CD4 T cells in response to infection .
16887981	0	CD4	95,98	TCR	77,80	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells engagement|compound|END_ENTITY	Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4 + T cells in steady-state homeostasis .
1690353	0	CD4	57,60	TCR	39,42	CD4	TCR	920	6962	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
1690353	0	CD4	91,94	TCR	39,42	CD4	TCR	920	6962	Gene	Gene	influenced|nmod|START_ENTITY thymocytes|dep|influenced thymocytes|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
22370222	0	CD4	211,214	TCR	38,41	CD4	TCR	920	6962	Gene	Gene	T|compound|START_ENTITY numbers|nmod|T activation|nmod|numbers reflects|dobj|activation cultured|ccomp|reflects cultured|nsubj|cells cells|compound|END_ENTITY	The activation , by antigen , of na ve TCR transgenic CD4 T cells cultured at physiological , rather than artificially high , frequencies more accurately reflects the in vivo activation of normal numbers of na ve CD4 -LRB- + -RRB- T cells .
22370222	0	CD4	53,56	TCR	38,41	CD4	TCR	920	6962	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	The activation , by antigen , of na ve TCR transgenic CD4 T cells cultured at physiological , rather than artificially high , frequencies more accurately reflects the in vivo activation of normal numbers of na ve CD4 -LRB- + -RRB- T cells .
25462565	0	CD4	27,30	TCR	153,156	CD4	TCR	920	6962	Gene	Gene	Visualization|nmod|START_ENTITY T-cell|nsubj|Visualization T-cell|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Visualization of the human CD4 -LRB- + -RRB- T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/yc -LRB- null -RRB- -LRB- NOG -RRB- mice by retrogenic expression of the human TCR gene .
26010129	0	CD4	83,86	TCR	13,16	CD4	TCR	920	6962	Gene	Gene	cells|compound|START_ENTITY maintenance|nmod|cells IL-2-dependent|dobj|maintenance IL-2-dependent|nsubj|drives drives|compound|END_ENTITY	Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4 + T cells in aged humans .
7514632	0	CD4	71,74	TCR	95,98	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	T|compound|START_ENTITY secretion|nmod|T dependence|nmod|secretion lymphocytes|nsubj|dependence lymphocytes|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Costimulator dependence of lymphokine secretion by naive and activated CD4 + T lymphocytes from TCR transgenic_mice .
7522245	0	CD4	18,21	TCR	87,90	CD4	TCR	920	6962	Gene	Gene	ligation|nmod|START_ENTITY induces|nsubj|ligation induces|dobj|activation activation|nmod|phosphorylation phosphorylation|compound|END_ENTITY	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation .
7867081	0	CD4	58,61	TCR	100,103	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	+|compound|START_ENTITY interactions|nmod|+ Disruption|nmod|interactions thymocytes|nsubj|Disruption thymocytes|dobj|results results|nmod|expression expression|compound|END_ENTITY	Disruption of intrathymic CD4-Ia interactions on immature CD4 + CD8 + thymocytes results in diminished TCR expression on mature CD8 + T cell progeny .
7901153	0	CD4	0,3	TCR	65,68	CD4	TCR	920	6962	Gene	Gene	comodulated|nsubjpass|START_ENTITY comodulated|nmod|T-cell_antigen_receptor T-cell_antigen_receptor|appos|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7901153	0	CD4	92,95	TCR	65,68	CD4	TCR	920	6962	Gene	Gene	line|compound|START_ENTITY activation|nmod|line comodulated|nmod|activation comodulated|nmod|T-cell_antigen_receptor T-cell_antigen_receptor|appos|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7915400	0	CD4	22,25	TCR	38,41	CD4	TCR	920	6962	Gene	Gene	selection|nmod|START_ENTITY +|nsubj|selection +|nmod|ligation ligation|compound|END_ENTITY	Positive selection of CD4 + T cells by TCR ligation without aggregation even in the absence of MHC .
8671590	0	CD4	62,65	TCR	93,96	CD4	TCR	920	6962	Gene	Gene	cells|compound|START_ENTITY aberrancies|nmod|cells signaling|dobj|aberrancies signaling|nmod|absence absence|nmod|co-stimulation co-stimulation|compound|END_ENTITY	HIV envelope-directed signaling aberrancies and cell death of CD4 + T cells in the absence of TCR co-stimulation .
8671613	0	CD4	46,49	TCR	70,73	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of CD40_ligand expression on naive CD4 T cells : a role for TCR but not co-stimulatory signals .
8752910	0	CD4	26,29	TCR	0,3	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY triggering|nmod|cells triggering|compound|END_ENTITY	TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation .
8921432	0	CD4	56,59	TCR	49,52	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|dobj|END_ENTITY	Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4 + CD8 + thymocytes .
8921432	0	CD4	85,88	TCR	49,52	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	thymocytes|compound|START_ENTITY expressed|nmod|thymocytes expressed|dobj|END_ENTITY	Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4 + CD8 + thymocytes .
9016871	0	CD4	18,21	TCR	52,55	CD4	TCR	920	6962	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands .
9596673	0	CD4	64,67	TCR	49,52	CD4	TCR	920	6962	Gene	Gene	thymocytes|nummod|START_ENTITY thymocytes|compound|END_ENTITY	Viral superantigen-induced negative selection of TCR transgenic CD4 + CD8 + thymocytes depends on activation , but not proliferation .
9649213	0	CD4	68,71	TCR	73,76	CD4	TCR	920	6962	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A pancolitis resembling human ulcerative_colitis -LRB- UC -RRB- is induced by CD4 + TCR alphabeta T cells of athymic origin in histocompatible severe_combined_immunodeficient -LRB- SCID -RRB- mice .
9796907	0	CD4	80,83	TCR	26,29	CD4	TCR	920	6962	Gene	Gene	age|nmod|START_ENTITY shifts|nmod|age shifts|nsubj|distribution distribution|nmod|lengths lengths|compound|END_ENTITY	The distribution of human TCR junctional region lengths shifts with age in both CD4 and CD8 T cells .
9831181	0	CD4	35,38	TCR	20,23	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|skewing skewing|nmod|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
9862685	0	CD4	148,151	TCR	116,119	CD4	TCR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Induction or protection from experimental_autoimmune_encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells .
7528767	0	CD4	78,81	TCR-alpha	123,132	CD4	TCR-alpha	920	28755	Gene	Gene	thymocytes|compound|START_ENTITY signaling|nmod|thymocytes receptor|acl|signaling induced|nmod|receptor induced|parataxis|response response|nsubj|synthesis synthesis|nmod|protein protein|amod|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
7528767	0	CD4	78,81	TCR-alpha	200,209	CD4	TCR-alpha	920	28755	Gene	Gene	thymocytes|compound|START_ENTITY signaling|nmod|thymocytes receptor|acl|signaling induced|nmod|receptor induced|parataxis|response response|nmod|signaling signaling|acl:relcl|compensates compensates|nmod|instability instability|amod|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
8617956	0	CD4	92,95	TCR-alpha	97,106	CD4	TCR-alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Salmonella_typhimurium aroA - infection in gene-targeted immunodeficient mice : major role of CD4 + TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location .
8871636	0	CD4	118,121	TCR-alpha	130,139	CD4	TCR-alpha	24932(Tax:10116)	290071(Tax:10116)	Gene	Gene	CD8|dep|START_ENTITY cytotoxicity|nmod|CD8 Involvement|nmod|cytotoxicity Involvement|dep|beta beta|amod|END_ENTITY	Involvement of peptide antigens in the cytotoxicity between 70-kDa_heat_shock_cognate_protein-like_molecule and CD3 + , CD4 - , CD8 - , TCR-alpha beta - killer T cells .
9413259	0	CD4	113,116	TCR-alpha	11,20	CD4	TCR-alpha	920	28755	Gene	Gene	T-cells|compound|START_ENTITY autoreactive|dobj|T-cells modulate|ccomp|autoreactive modulate|nsubj|beta beta|compound|END_ENTITY	Human CD8 + TCR-alpha beta -LRB- + -RRB- and TCR-gamma delta -LRB- + -RRB- cells modulate autologous autoreactive neuroantigen-specific CD4 + T-cells by different mechanisms .
10464179	0	CD4	7,10	TCR_alpha	25,34	CD4	TCR alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|dobj|cells cells|nmod|class class|compound|END_ENTITY	Unique CD4 -LRB- + -RRB- T cells in TCR_alpha chain-deficient class I MHC-restricted TCR transgenic_mice : role in a superantigen-mediated disease process .
24886643	0	CD4	49,52	TCR_alpha	10,19	CD4	TCR alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	profile|compound|START_ENTITY favors|dobj|profile favors|nsubj|CDR3 CDR3|compound|END_ENTITY	Elongated TCR_alpha chain CDR3 favors an altered CD4 cytokine profile .
9137250	0	CD4	0,3	TCR_alpha	10,19	CD4	TCR alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	CD8|nummod|START_ENTITY CD8|dep|END_ENTITY	CD4 - CD8 - TCR_alpha / beta + suppressor T cells demonstrated in mice 1 day after thermal_injury .
9541577	0	CD4	50,53	TCR_alpha	2,11	CD4	TCR alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	maturation|nmod|START_ENTITY induces|dobj|maturation induces|nsubj|transgene transgene|compound|END_ENTITY	A TCR_alpha chain transgene induces maturation of CD4 - CD8 - alpha beta + T cells from gamma delta T cell precursors .
9725264	0	CD4	33,36	TCR_alpha	18,27	CD4	TCR alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mature mainstream TCR_alpha beta + CD4 + thymocytes expressing L-selectin mediate `` active tolerance '' in the nonobese diabetic mouse .
26582240	0	CD4	23,26	TGF-Beta	4,12	CD4	TGF-Beta	920	7040	Gene	Gene	CD25|compound|START_ENTITY Subset|nmod|CD25 Subset|compound|END_ENTITY	LAP TGF-Beta Subset of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- - -RRB- Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients .
20540113	0	CD4	94,97	TGF-b	0,5	CD4	TGF-b	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	T|compound|START_ENTITY trigger|nmod|T trigger|nsubj|interactions interactions|amod|END_ENTITY	TGF-b interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4 -LRB- + -RRB- T cells .
21057085	0	CD4	94,97	TGF-b	74,79	CD4	TGF-b	920	7040	Gene	Gene	CD25|compound|START_ENTITY convert|dobj|CD25 agonists|dep|convert agonists|nmod|END_ENTITY	Peroxisome proliferator-activated receptor a and y agonists together with TGF-b convert human CD4 + CD25 - T cells into functional Foxp3 + regulatory T cells .
21124798	0	CD4	47,50	TGF-b	0,5	CD4	TGF-b	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
21494571	0	CD4	7,10	TGF-b	41,46	CD4	TGF-b	920	7040	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|form form|nmod|END_ENTITY	Murine CD4 T cells produce a new form of TGF-b as measured by a newly developed TGF-b bioassay .
21494571	0	CD4	7,10	TGF-b	80,85	CD4	TGF-b	920	7040	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|advcl|measured measured|nmod|bioassay bioassay|amod|END_ENTITY	Murine CD4 T cells produce a new form of TGF-b as measured by a newly developed TGF-b bioassay .
21655250	0	CD4	31,34	TGF-b	76,81	CD4	TGF-b	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ facilitated|nmod|proliferation facilitated|nmod|END_ENTITY	In situ prior proliferation of CD4 + CCR6 + regulatory T cells facilitated by TGF-b secreting DCs is crucial for their enrichment and suppression in tumor immunity .
21839859	0	CD4	0,3	TGF-b	42,47	CD4	TGF-b	24932(Tax:10116)	59086(Tax:10116)	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|dobj|cells cells|acl|induced induced|nmod|bronchiolitis bronchiolitis|amod|END_ENTITY	CD4 + Foxp3 + regulatory T cells induced by TGF-b , IL-2 and all-trans_retinoic_acid attenuate obliterative bronchiolitis in rat trachea transplantation .
22728763	0	CD4	89,92	TGF-b	80,85	CD4	TGF-b	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|secretion secretion|nmod|END_ENTITY	Targeting Janus_tyrosine_kinase_3 -LRB- JAK3 -RRB- with an inhibitor induces secretion of TGF-b by CD4 + T cells .
23741351	0	CD4	70,73	TGF-b	0,5	CD4	TGF-b	920	7040	Gene	Gene	+|compound|START_ENTITY differentiation|nmod|+ differentiation|amod|END_ENTITY	TGF-b enhanced IL-21-induced differentiation of human IL-21-producing CD4 + T cells via Smad3 .
23844100	0	CD4	33,36	TGF-b	54,59	CD4	TGF-b	920	7040	Gene	Gene	CD8a|compound|START_ENTITY induction|nmod|CD8a T|nmod|induction T|nmod|END_ENTITY	In vitro induction of regulatory CD4 + CD8a + T cells by TGF-b , IL-7_and_IFN-y .
24115907	0	CD4	33,36	TGF-b	0,5	CD4	TGF-b	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	homeostasis|compound|START_ENTITY required|nmod|homeostasis required|nsubjpass|signalling signalling|amod|END_ENTITY	TGF-b signalling is required for CD4 T cell homeostasis but dispensable for regulatory T cell function .
24454972	0	CD4	28,31	TGF-b	12,17	CD4	TGF-b	920	7040	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
25132806	0	CD4	24,27	TGF-b	38,43	CD4	TGF-b	920	7040	Gene	Gene	Foxp3|compound|START_ENTITY percentage|nmod|Foxp3 END_ENTITY|nsubj|percentage	Decreased percentage of CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- TGF-b -LRB- + -RRB- and increased percentage of CD4 -LRB- + -RRB- IL-17 -LRB- + -RRB- cells in bronchoalveolar lavage of asthmatics .
26067079	0	CD4	0,3	TGF-b	132,137	CD4	TGF-b	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	Natural|compound|START_ENTITY Killer|nsubj|Natural Killer|dobj|Hepatocytotoxicity Hepatocytotoxicity|nmod|Transgenic_Mice Transgenic_Mice|nmod|END_ENTITY	CD4 + CD25 + Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis_B_Virus Transgenic_Mice via Membrane-Bound TGF-b and OX40 .
26541894	0	CD4	60,63	TGF-b	0,5	CD4	TGF-b	920	7040	Gene	Gene	T|compound|START_ENTITY differentiation|nmod|T cells|compound|differentiation induces|dobj|cells induces|nsubj|END_ENTITY	TGF-b induces the differentiation of human CXCL13-producing CD4 -LRB- + -RRB- T cells .
26708888	0	CD4	32,35	TGF-b	78,83	CD4	TGF-b	920	7040	Gene	Gene	CD25|compound|START_ENTITY Expression|nmod|CD25 -LSB-|dobj|Expression -LSB-|dep|Cells Cells|appos|mRNA mRNA|compound|END_ENTITY	-LSB- Expression and Significance of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CDl27 -LRB- low -RRB- Regulatory T Cells , TGF-b and Notch1 mRNA in Patients with Idiopathic_Thrombocytopenic_Purpura -RSB- .
27075967	0	CD4	25,28	TGF-b	89,94	CD4	TGF-b	920	7040	Gene	Gene	Foxp3|compound|START_ENTITY cells|nsubj|Foxp3 cells|nmod|binding binding|nmod|END_ENTITY	Human macrophages induce CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via binding and re-release of TGF-b .
22749982	0	CD4	61,64	TGF-b1	37,43	CD4	TGF-b1	920	7040	Gene	Gene	CD25|compound|START_ENTITY Induction|dep|CD25 Induction|nmod|CD152 CD152|appos|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
24904415	0	CD4	0,3	TGF-b1	119,125	CD4	TGF-b1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY inhibit|nsubj|Tregs inhibit|dobj|recruitment recruitment|nmod|suppression suppression|nmod|production production|nmod|lung lung|amod|exposed exposed|amod|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
12651220	0	CD4	30,33	TGF-beta	0,8	CD4	TGF-beta	920	7040	Gene	Gene	immunosuppression|compound|START_ENTITY link|nmod|immunosuppression END_ENTITY|dep|link	TGF-beta : the missing link in CD4 + CD25 + regulatory T cell-mediated immunosuppression .
10619862	0	CD4	0,3	TGF-beta1	51,60	CD4	TGF-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|dobj|cells cells|acl|engineered engineered|xcomp|produce produce|ccomp|reverse reverse|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway_hyperreactivity and inflammation .
15016653	0	CD4	86,89	TGF-beta1	140,149	CD4	TGF-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells inflammation|nmod|suppression inflammation|nmod|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15557315	0	CD4	99,102	TGF-beta1	86,95	CD4	TGF-beta1	920	7040	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Anti-CD28-induced co-stimulation and TCR avidity regulates the differential effect of TGF-beta1 on CD4 + and CD8 + na ve human T-cells .
15809351	0	CD4	64,67	TGF-beta1	0,9	CD4	TGF-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells maintains|dobj|function maintains|nsubj|END_ENTITY	TGF-beta1 maintains suppressor function and Foxp3 expression in CD4 + CD25 + regulatory T cells .
16180248	0	CD4	24,27	TGF-beta1	0,9	CD4	TGF-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	TGF-beta1 production by CD4 + CD25 + regulatory T cells is not essential for suppression of intestinal_inflammation .
16648238	0	CD4	88,91	TGF-beta1	0,9	CD4	TGF-beta1	920	7040	Gene	Gene	lymphocytes|compound|START_ENTITY influence|nmod|lymphocytes influence|nsubj|END_ENTITY	TGF-beta1 in SP-A preparations influence immune suppressive properties of SP-A on human CD4 + T lymphocytes .
16751781	0	CD4	19,22	TGF-beta1	80,89	CD4	TGF-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	repertoire|compound|START_ENTITY Restriction|nmod|repertoire prevents|nsubj|Restriction prevents|dobj|pathology pathology|nmod|mice mice|compound|END_ENTITY	Restriction of the CD4 + T-cell receptor repertoire prevents immune pathology in TGF-beta1 knockout mice .
17307871	0	CD4	51,54	TGF-beta1	21,30	CD4	TGF-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|amod|naive naive|nmod:npmod|differentiate differentiate|nummod|END_ENTITY	Dendritic cells with TGF-beta1 differentiate naive CD4 + CD25 - T cells into islet-protective Foxp3 + regulatory T cells .
17475784	0	CD4	73,76	TGF-beta1	0,9	CD4	TGF-beta1	920	7040	Gene	Gene	subsets|compound|START_ENTITY expression|nmod|subsets modulates|dobj|expression modulates|nsubj|END_ENTITY	TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4 + T cell subsets .
20081874	0	CD4	114,117	TGF-beta1	0,9	CD4	TGF-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY inflammatory_bowel_disease|nmod|Foxp3 cells|amod|inflammatory_bowel_disease development|nmod|cells delay|dobj|development delay|ccomp|gene-modified gene-modified|advmod|END_ENTITY	TGF-beta1 gene-modified , immature dendritic cells delay the development of inflammatory_bowel_disease by inducing CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
24950027	0	CD4	11,14	TGF-beta1	138,147	CD4	TGF-beta1	920	7040	Gene	Gene	CD25|compound|START_ENTITY Cord|dobj|CD25 fail|dep|Cord fail|xcomp|inhibit inhibit|xcomp|due due|nmod|production production|nmod|END_ENTITY	Cord blood CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells fail to inhibit cord blood NK cell functions due to insufficient production and expression of TGF-beta1 .
9207402	0	CD4	18,21	TGF-beta1	123,132	CD4	TGF-beta1	920	7040	Gene	Gene	antigen|compound|START_ENTITY engagement|nmod|antigen up-regulates|nsubj|engagement up-regulates|dobj|activity activity|dep|END_ENTITY	The engagement of CD4 surface antigen in the HEL haemopoietic cell line up-regulates the transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- promoter activity .
14707053	0	CD4	55,58	TGF-beta_1	0,10	CD4	TGF-beta 1	920	7040	Gene	Gene	activity|compound|START_ENTITY mechanism|nmod|activity role|nmod|mechanism plays|dobj|role plays|nsubj|END_ENTITY	TGF-beta_1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice .
15048715	0	CD4	0,3	TGF-beta_1	43,53	CD4	TGF-beta 1	24932(Tax:10116)	59086(Tax:10116)	Gene	Gene	T|compound|START_ENTITY T|parataxis|END_ENTITY	CD4 + effector T cell distribution in vivo : TGF-beta_1 / TGF-beta receptor II interaction during activation mediates accumulation in the target tissue by preferential proliferation .
15699137	0	CD4	34,37	TGF-beta_1	20,30	CD4	TGF-beta 1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Distinct effects of TGF-beta_1 on CD4 + and CD8 + T cell survival , division , and IL-2 production : a role for T cell intrinsic Smad3 .
15879087	0	CD4	71,74	TGF-beta_1	0,10	CD4	TGF-beta 1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells inhibit|dobj|expression uses|xcomp|inhibit uses|nsubj|END_ENTITY	TGF-beta_1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4 + T cells at priming and at recall : differential involvement of Stat4 and T-bet .
17579023	0	CD4	38,41	TGF-beta_1	0,10	CD4	TGF-beta 1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	TGF-beta_1 regulates antigen-specific CD4 + T cell responses in the periphery .
17911604	0	CD4	55,58	TGF-beta_1	85,95	CD4	TGF-beta 1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induces|dobj|+ induces|parataxis|adaptive adaptive|nsubj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
19109141	0	CD4	6,9	TGF-beta_1	115,125	CD4	TGF-beta 1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|appos|proliferation proliferation|nmod|END_ENTITY	CD69 + CD4 + CD25 - T cells , a new subset of regulatory T cells , suppress T cell proliferation through membrane-bound TGF-beta_1 .
22049790	0	CD4	16,19	TGF-beta_1	52,62	CD4	TGF-beta 1	920	7040	Gene	Gene	CD25|compound|START_ENTITY CD25|amod|END_ENTITY	-LSB- Expressions of CD4 + CD25 -LRB- high -RRB- regulatory T cells , TGF-beta_1 and COX-2 in the peripheral blood of prostate_cancer patients -RSB- .
8642767	0	CD4	181,184	TGF-beta_1	62,72	CD4	TGF-beta 1	920	7040	Gene	Gene	CD3|dep|START_ENTITY level|appos|CD3 level|appos|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
7561083	0	CD4	68,71	TGF-beta_2	20,30	CD4	TGF-beta 2	12504(Tax:10090)	21808(Tax:10090)	Gene	Gene	T|compound|START_ENTITY development|nmod|T END_ENTITY|nmod|development	Opposing effects of TGF-beta_2 on the Th1 cell development of naive CD4 + T cells isolated from different mouse strains .
9138446	0	CD4	50,53	TGF_beta_2	0,10	CD4	TGF beta 2	100009152(Tax:9986)	7042	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGF_beta_2 in rabbit blastocoelic fluid regulates CD4 membrane expression : possible role in the success of gestation .
10231330	0	CD4	43,46	TH1	111,114	CD4	TH1	920	51497	Gene	Gene	cells|compound|START_ENTITY defect|nmod|cells involved|nsubjpass|defect involved|nmod|abnormality abnormality|nmod|immunity immunity|nummod|END_ENTITY	The quantitative and qualitative defect of CD4 + CD45RO + memory-type T cells are involved in the abnormality of TH1 immunity in atopic_dermatitis patients .
11786644	0	CD4	80,83	TH1	29,32	CD4	TH1	920	51497	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells lineage|dobj|production lineage|nsubj|effects effects|nmod|T-bet T-bet|nmod|END_ENTITY	Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells .
12704370	0	CD4	6,9	TH1	88,91	CD4	TH1	920	51497	Gene	Gene	cells|compound|START_ENTITY able|nsubj|cells able|xcomp|suppress suppress|dobj|production production|compound|END_ENTITY	Human CD4 + CD25 + T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production .
17325053	0	CD4	0,3	TH1	119,122	CD4	TH1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|suppress suppress|ccomp|function function|dobj|development development|nmod|responses responses|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress CD4 + T-cell function and inhibit the development of Plasmodium_berghei-specific TH1 responses involved in cerebral_malaria pathogenesis .
17325053	0	CD4	39,42	TH1	119,122	CD4	TH1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY function|nsubj|T-cell function|dobj|development development|nmod|responses responses|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress CD4 + T-cell function and inhibit the development of Plasmodium_berghei-specific TH1 responses involved in cerebral_malaria pathogenesis .
18774396	0	CD4	90,93	TH1	71,74	CD4	TH1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4 + T cells .
19344461	0	CD4	9,12	TH1	14,17	CD4	TH1	920	51497	Gene	Gene	+|nsubj|START_ENTITY +|dobj|antibodies antibodies|compound|END_ENTITY	Indirect CD4 + TH1 response , antidonor antibodies and diffuse C4d graft deposits in long-term recipients conditioned by donor antigens priming .
20463596	0	CD4	0,3	TH1	5,8	CD4	TH1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	CD4 + TH1 cells generated by Ii-PADRE DNA at prime phase are important to induce effectors and memory CD8 + T cells .
2905998	1	CD4	202,205	TH1	207,210	CD4	TH1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Evidence for the physiological role of the CD4 + TH1 + subset in mice .
7691279	0	CD4	39,42	TH1	44,47	CD4	TH1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	The 3G11 + antigen , a marker for murine CD4 + TH1 lymphocytes , is a ganglioside .
8625361	0	CD4	40,43	TH1	17,20	CD4	TH1	920	51497	Gene	Gene	cells|compound|START_ENTITY subsets|nmod|cells subsets|nsubj|Disregulation Disregulation|nmod|END_ENTITY	Disregulation in TH1 and TH2 subsets of CD4 + T cells in peripheral blood of colorectal_cancer patients and involvement in cancer establishment and progression .
9394724	0	CD4	7,10	TH1	54,57	CD4	TH1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	T-cell|nsubj|START_ENTITY T-cell|parataxis|enhance enhance|nsubj|cells cells|compound|END_ENTITY	Murine CD4 T-cell response to Helicobacter_infection : TH1 cells enhance gastritis and TH2 cells reduce bacterial load .
15990796	0	CD4	86,89	TH2	63,66	CD4	TH2	920	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cytokines|nmod|cells cytokines|nsubj|effects effects|nmod|IFN-alpha IFN-alpha|nmod|expression expression|nmod|END_ENTITY	Differential effects of IFN-alpha on the expression of various TH2 cytokines in human CD4 + T cells .
1972676	0	CD4	2,5	TH2	7,10	CD4	TH2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	line|compound|START_ENTITY line|compound|END_ENTITY	A CD4 + TH2 cell line isolated from mice chronically infected with Trypanosoma_cruzi induces IgG2 polyclonal response in vivo .
1976523	0	CD4	93,96	TH2	123,126	CD4	TH2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY different|nsubj|cells different|nmod|cells cells|nummod|END_ENTITY	Resistance to murine cutaneous_leishmaniasis is mediated by TH1 cells , but disease-promoting CD4 + cells are different from TH2 cells .
23137033	0	CD4	19,22	TIM-1	10,15	CD4	TIM-1	12504(Tax:10090)	117216(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation .
19676072	0	CD4	38,41	TIM-3	0,5	CD4	TIM-3	920	84868	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	TIM-3 is expressed on activated human CD4 + T cells and regulates Th1 and Th17 cytokines .
22445722	0	CD4	47,50	TIM-3	73,78	CD4	TIM-3	920	84868	Gene	Gene	production|nmod|START_ENTITY Down-regulation|nmod|production T|nsubj|Down-regulation T|dep|expressing expressing|dobj|END_ENTITY	Down-regulation of interleukin-2 production by CD4 -LRB- + -RRB- T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription .
24689929	0	CD4	23,26	TIM-3	14,19	CD4	TIM-3	920	84868	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Expression of TIM-3 on CD4 + and CD8 + T cells in the peripheral blood and synovial fluid of rheumatoid_arthritis .
25676534	0	CD4	9,12	TIM-3	19,24	CD4	TIM-3	12504(Tax:10090)	171285(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Negative CD4 + TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation .
25937557	0	CD4	105,108	TIM-3	0,5	CD4	TIM-3	920	84868	Gene	Gene	Cells|compound|START_ENTITY Gamma|nmod|Cells Interfering|nmod|Gamma Variations|advcl|Interfering Variations|nsubj|Genetic Genetic|compound|END_ENTITY	TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4 + T Cells .
26062425	0	CD4	27,30	TIM-3	18,23	CD4	TIM-3	920	84868	Gene	Gene	tumor|compound|START_ENTITY END_ENTITY|nmod|tumor	-LSB- Up-regulation of TIM-3 on CD4 -LRB- + -RRB- tumor infiltrating lymphocytes predicts poor prognosis in human non-small-cell lung_cancer -RSB- .
25790134	0	CD4	46,49	TLR-2	0,5	CD4	TLR-2	12504(Tax:10090)	24088(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Production|nmod|Foxp3 Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
22749982	0	CD4	61,64	TLR-4	90,95	CD4	TLR-4	920	7099	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
16337148	0	CD4	81,84	TLR2	0,4	CD4	TLR2	12504(Tax:10090)	24088(Tax:10090)	Gene	Gene	apoptosis|nummod|START_ENTITY inducing|dobj|apoptosis murine|dep|inducing murine|nsubj|ameliorates ameliorates|compound|END_ENTITY	TLR2 agonist ameliorates murine experimental allergic_conjunctivitis by inducing CD4 positive T-cell apoptosis rather than by affecting the Th1/Th2 balance .
16767222	0	CD4	31,34	TLR2	80,84	CD4	TLR2	920	7097	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Heat_shock protein 60 enhances CD4 + CD25 + regulatory T cell function via innate TLR2 signaling .
19882655	0	CD4	0,3	TLR2	90,94	CD4	TLR2	12504(Tax:10090)	24088(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY dependent|nsubj|Treg dependent|advmod|END_ENTITY	CD4 + CD25 + Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma_japonicum is TLR2 dependent .
20157599	0	CD4	35,38	TLR2	27,31	CD4	TLR2	920	7097	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|nmod|END_ENTITY	Expression and Function of TLR2 on CD4 Versus CD8 T Cells .
21273544	0	CD4	67,70	TLR2	14,18	CD4	TLR2	100009152(Tax:9986)	100009578(Tax:9986)	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells reverses|dobj|function reverses|nsubj|Engagement Engagement|nmod|END_ENTITY	Engagement of TLR2 reverses the suppressor function of conjunctiva CD4 + CD25 + regulatory T cells and promotes herpes_simplex_virus epitope-specific CD4 + CD25 - effector T cell responses .
22467654	0	CD4	107,110	TLR2	61,65	CD4	TLR2	920	7097	Gene	Gene	lymphocytes|compound|START_ENTITY facilitating|nmod|lymphocytes activate|advcl|facilitating activate|dobj|cells cells|nmod|END_ENTITY	Herpes simplex virus antigens directly activate NK cells via TLR2 , thus facilitating their presentation to CD4 T lymphocytes .
23628056	0	CD4	19,22	TLR2	53,57	CD4	TLR2	920	7097	Gene	Gene	CD25|compound|START_ENTITY Changes|appos|CD25 Changes|appos|END_ENTITY	-LSB- Changes of FoxP3 , CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , TLR2 and TLR9 in children with infectious_mononucleosis -RSB- .
24497180	0	CD4	19,22	TLR2	0,4	CD4	TLR2	920	24088(Tax:10090)	Gene	Gene	T|compound|START_ENTITY engagement|nmod|T cells|amod|engagement cells|amod|END_ENTITY	TLR2 engagement on CD4 -LRB- + -RRB- T cells enhances effector functions and protective responses to Mycobacterium_tuberculosis .
26079624	0	CD4	32,35	TLR2	24,28	CD4	TLR2	920	7097	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Increased expression of TLR2 in CD4 -LRB- + -RRB- T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications .
16339542	0	CD4	118,121	TLR5	27,31	CD4	TLR5	920	7100	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|nsubj|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
11009092	0	CD4	37,40	TNF-alpha	73,82	CD4	TNF-alpha	920	7124	Gene	Gene	START_ENTITY|acl|+ +|dobj|thymocytes thymocytes|nmod|END_ENTITY	Sex steroids induce apoptosis of CD8 + CD4 + double-positive thymocytes via TNF-alpha .
11123285	0	CD4	113,116	TNF-alpha	46,55	CD4	TNF-alpha	920	7124	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|signal signal|nmod|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
12296856	0	CD4	118,121	TNF-alpha	68,77	CD4	TNF-alpha	920	7124	Gene	Gene	co-stimulation|nmod|START_ENTITY cells|amod|co-stimulation have|nmod|cells have|dobj|effects effects|nmod|END_ENTITY	Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
15733870	0	CD4	71,74	TNF-alpha	11,20	CD4	TNF-alpha	920	7124	Gene	Gene	lymphocytes|compound|START_ENTITY operated|nmod|lymphocytes operated|nsubj|store store|compound|END_ENTITY	Persistent TNF-alpha exposure impairs store operated calcium influx in CD4 + T lymphocytes .
16301684	0	CD4	34,37	TNF-alpha	76,85	CD4	TNF-alpha	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	clones|compound|START_ENTITY function|nmod|clones function|dep|role role|nmod|END_ENTITY	Effector function of diabetogenic CD4 Th1 T cell clones : a central role for TNF-alpha .
18053016	0	CD4	38,41	TNF-alpha	106,115	CD4	TNF-alpha	920	7124	Gene	Gene	cells|compound|START_ENTITY insufficiency|nmod|cells subjected|nsubjpass|insufficiency subjected|nmod|modulation modulation|amod|END_ENTITY	The functional insufficiency of human CD4 + CD25 high T-regulatory cells in allergic_asthma is subjected to TNF-alpha modulation .
18178849	0	CD4	64,67	TNF-alpha	0,9	CD4	TNF-alpha	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY population|nmod|cells generates|dobj|population generates|nsubj|antagonism antagonism|amod|END_ENTITY	TNF-alpha antagonism generates a population of antigen-specific CD4 + CD25 + T cells that inhibit protective immunity in murine histoplasmosis .
19667063	0	CD4	94,97	TNF-alpha	10,19	CD4	TNF-alpha	920	7124	Gene	Gene	cells|nummod|START_ENTITY Decreased|nsubj|cells Decreased|dobj|synthesis synthesis|amod|END_ENTITY	Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4 + T cells during aging .
19931858	0	CD4	83,86	TNF-alpha	23,32	CD4	TNF-alpha	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells responsible|nmod|development responsible|nsubj|END_ENTITY	Dendritic cell-derived TNF-alpha is responsible for development of IL-10-producing CD4 + T cells .
20173391	0	CD4	27,30	TNF-alpha	0,9	CD4	TNF-alpha	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activator|nmod|cells END_ENTITY|dep|activator	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20364089	0	CD4	100,103	TNF-alpha	73,82	CD4	TNF-alpha	920	7124	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Control_of_vaccinia_virus skin_lesions by long-term-maintained IFN-gamma + TNF-alpha + effector/memory CD4 + lymphocytes in humans .
2228021	0	CD4	49,52	TNF-alpha	23,32	CD4	TNF-alpha	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cytolysis|nmod|+ Evidence|nmod|cytolysis Evidence|nmod|role role|nmod|END_ENTITY	Evidence of a role for TNF-alpha in cytolysis by CD4 + , class II MHC-restricted cytotoxic T cells .
7517419	0	CD4	125,128	TNF-alpha	0,9	CD4	TNF-alpha	24932(Tax:10116)	24835(Tax:10116)	Gene	Gene	T|compound|START_ENTITY adhesion|nmod|T enhances|dobj|adhesion associated|dep|enhances associated|advmod|END_ENTITY	TNF-alpha associated with fibronectin enhances phorbol_myristate_acetate - or antigen-mediated integrin-dependent adhesion of CD4 + T cells via protein tyrosine phosphorylation .
9218822	0	CD4	90,93	TNF-alpha	38,47	CD4	TNF-alpha	920	7124	Gene	Gene	anergy|compound|START_ENTITY induction|nmod|anergy factor-alpha|nmod|induction factor-alpha|appos|END_ENTITY	Role of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- in the induction of HIV-1 gp120-mediated CD4 + T cell anergy .
9374446	0	CD4	32,35	TNF-alpha	0,9	CD4	TNF-alpha	920	7124	Gene	Gene	T-lymphocytes|nummod|START_ENTITY apoptosis|nmod|T-lymphocytes mediated|dobj|apoptosis mediated|nsubj|END_ENTITY	TNF-alpha mediated apoptosis of CD4 positive T-lymphocytes .
9826442	0	CD4	67,70	TNF-alpha	0,9	CD4	TNF-alpha	920	7124	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|plays plays|nsubj|END_ENTITY	TNF-alpha , not CD154 -LRB- CD40L -RRB- , plays a major role in SEB-dependent , CD4 -LRB- + -RRB- T cell-induced endothelial cell activation in vitro .
18453563	0	CD4	82,85	TNFR2	28,33	CD4	TNFR2	12504(Tax:10090)	21938(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells defines|dobj|subset defines|nsubj|expression expression|nmod|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
19551899	0	CD4	28,31	TNFR2	8,13	CD4	TNFR2	12504(Tax:10090)	21938(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Lack of TNFR2 expression by CD4 -LRB- + -RRB- T cells exacerbates experimental colitis .
20127680	0	CD4	66,69	TNFR2	17,22	CD4	TNFR2	920	7133	Gene	Gene	FOXP3|compound|START_ENTITY more|nmod|FOXP3 +|nsubj|more identifies|dep|+ identifies|nsubj|Co-expression Co-expression|nmod|END_ENTITY	Co-expression of TNFR2 and CD25 identifies more of the functional CD4 + FOXP3 + regulatory T cells in human peripheral blood .
20173391	0	CD4	27,30	TNFR2	37,42	CD4	TNFR2	12504(Tax:10090)	21938(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20525892	0	CD4	106,109	TNFR2	28,33	CD4	TNFR2	12504(Tax:10090)	21938(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|Expression Expression|nmod|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	CD4	56,59	TNFR2	28,33	CD4	TNFR2	12504(Tax:10090)	21938(Tax:10090)	Gene	Gene	FoxP3|compound|START_ENTITY resistance|nmod|FoxP3 induces|dobj|resistance induces|nsubj|Expression Expression|nmod|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
23277487	0	CD4	47,50	TNFR2	0,5	CD4	TNFR2	12504(Tax:10090)	21938(Tax:10090)	Gene	Gene	phenotype|compound|START_ENTITY stabilization|nmod|phenotype critical|nmod|stabilization critical|nsubj|END_ENTITY	TNFR2 is critical for the stabilization of the CD4 + Foxp3 + regulatory T. cell phenotype in the inflammatory environment .
23964278	0	CD4	77,80	TNFR2	0,5	CD4	TNFR2	920	7133	Gene	Gene	Effectors|compound|START_ENTITY Stimulation|nmod|Effectors Induced|nmod|Stimulation T|dobj|Induced T|nsubj|Expression Expression|compound|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
11571353	0	CD4	23,26	TNFalpha	0,8	CD4	TNFalpha	920	7124	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|compound|END_ENTITY	TNFalpha production by CD4 -LRB- + -RRB- T cells predicts long-term increase in lesion load on MRI in MS. Reliable laboratory prognostic factors for MS are still lacking .
16888034	0	CD4	12,15	TRAG-3	42,48	CD4	TRAG-3	920	102723547	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	Spontaneous CD4 + T cell responses against TRAG-3 in patients with melanoma and breast_cancers .
10706675	0	CD4	52,55	TRAIL	0,5	CD4	TRAIL	920	8743	Gene	Gene	killing|compound|START_ENTITY mediate|dobj|killing mediate|nsubj|END_ENTITY	TRAIL -LRB- Apo2 ligand -RRB- and TWEAK -LRB- Apo3_ligand -RRB- mediate CD4 + T cell killing of antigen-presenting macrophages .
11264173	0	CD4	36,39	TRAIL	0,5	CD4	TRAIL	920	8743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	TRAIL expression by activated human CD4 -LRB- + -RRB- V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid_leukemia cells .
11588045	0	CD4	163,166	TRAIL	117,122	CD4	TRAIL	920	8743	Gene	Gene	T|compound|START_ENTITY down-modulation|nmod|T cells|amod|down-modulation induces|nmod|cells induces|nsubj|ligand ligand|appos|END_ENTITY	Human_herpesvirus_7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- coupled to TRAIL-R1 down-modulation in CD4 -LRB- + -RRB- T cells .
12960299	0	CD4	31,34	TRAIL	8,13	CD4	TRAIL	12504(Tax:10090)	22035(Tax:10090)	Gene	Gene	rejection|compound|START_ENTITY Role|nmod|rejection Role|nmod|END_ENTITY	Role of TRAIL and IFN-gamma in CD4 + T cell-dependent tumor rejection in the anterior chamber of the eye .
17339497	0	CD4	58,61	TRAIL	7,12	CD4	TRAIL	12504(Tax:10090)	22035(Tax:10090)	Gene	Gene	numbers|compound|START_ENTITY sustaining|dobj|numbers promotes|dep|sustaining promotes|nsubj|END_ENTITY	T cell TRAIL promotes murine lupus by sustaining effector CD4 Th cell numbers and by inhibiting CD8 CTL activity .
18354179	0	CD4	89,92	TRAIL	0,5	CD4	TRAIL	12504(Tax:10090)	22035(Tax:10090)	Gene	Gene	help|compound|START_ENTITY absence|nmod|help generated|nmod|absence memory|acl|generated rescue|dobj|memory rescue|nsubj|deficiency deficiency|compound|END_ENTITY	TRAIL deficiency does not rescue impaired CD8 + T cell memory generated in the absence of CD4 + T cell help .
19690337	0	CD4	54,57	TRAIL	37,42	CD4	TRAIL	920	8743	Gene	Gene	+|compound|START_ENTITY apoptosis|nummod|+ END_ENTITY|dobj|apoptosis	Plasmacytoid dendritic cells express TRAIL and induce CD4 + T-cell apoptosis in HIV-1_viremic patients .
20430391	0	CD4	90,93	TRAIL	60,65	CD4	TRAIL	920	8743	Gene	Gene	cells|compound|START_ENTITY reduce|nmod|cells reduce|dobj|apoptosis apoptosis|nmod|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Statins reduce endothelial cell apoptosis via inhibition of TRAIL expression on activated CD4 T cells in acute_coronary_syndrome .
25367576	0	CD4	26,29	TRAIL	0,5	CD4	TRAIL	920	8743	Gene	Gene	T|nsubj|START_ENTITY T|nsubj|END_ENTITY	TRAIL -LRB- + -RRB- NK Cells Control CD4 -LRB- + -RRB- T Cell Responses during Chronic Viral_Infection to Limit Autoimmunity .
26700618	0	CD4	25,28	TRPV1	12,17	CD4	TRPV1	12504(Tax:10090)	193034(Tax:10090)	Gene	Gene	response|compound|START_ENTITY Role|nmod|response Role|nmod|END_ENTITY	The Role of TRPV1 in the CD4 + T cell-mediated inflammatory response of allergic_rhinitis .
16585583	0	CD4	30,33	T_cell_factor-1	53,68	CD4	T cell factor-1	12504(Tax:10090)	21414(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|nmod|END_ENTITY	Transcriptional regulation of CD4 gene expression by T_cell_factor-1 / beta-catenin pathway .
11157053	0	CD4	0,3	T_cell_receptor	60,75	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|hyperresponsive hyperresponsive|xcomp|END_ENTITY	CD4 -LRB- + -RRB- T cells from lupus-prone mice are hyperresponsive to T_cell_receptor engagement with low and high affinity peptide antigens : a model to explain spontaneous T cell activation in lupus .
11560989	0	CD4	28,31	T_cell_receptor	80,95	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	Anergy|nmod|START_ENTITY cells|amod|Anergy induced|nsubj|cells induced|nmod|engagement engagement|nmod|END_ENTITY	Anergy in peripheral memory CD4 -LRB- + -RRB- T cells induced by low avidity engagement of T_cell_receptor .
1623924	0	CD4	70,73	T_cell_receptor	13,28	CD4	T cell receptor	920	6962	Gene	Gene	+|compound|START_ENTITY diversity|nmod|+ diversity|compound|END_ENTITY	Specificity , T_cell_receptor diversity and activation requirements of CD4 + and CD8 + clones derived from human melanoma-infiltrating lymphocytes .
1696186	0	CD4	18,21	T_cell_receptor	75,90	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY Subpopulations|nmod|cells Subpopulations|dep|differences differences|nmod|expression expression|nmod|END_ENTITY	Subpopulations of CD4 + cells in lpr/lpr mice : differences in expression of T_cell_receptor / CD3 complex and proliferative responses .
17113120	0	CD4	107,110	T_cell_receptor	111,126	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY ligation|compound|END_ENTITY	Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease : Is CD4 T_cell_receptor ligation needed ?
17113120	0	CD4	51,54	T_cell_receptor	111,126	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|mediate mediate|dobj|disease disease|dep|needed needed|nsubjpass|ligation ligation|compound|END_ENTITY	Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease : Is CD4 T_cell_receptor ligation needed ?
2120773	0	CD4	66,69	T_cell_receptor	14,29	CD4	T cell receptor	920	6962	Gene	Gene	CD8|compound|START_ENTITY expression|nmod|CD8 expression|compound|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
2120773	0	CD4	84,87	T_cell_receptor	14,29	CD4	T cell receptor	920	6962	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Inhibition Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
7679649	0	CD4	56,59	T_cell_receptor	95,110	CD4	T cell receptor	920	6962	Gene	Gene	cells|nummod|START_ENTITY cells|acl|recognizing recognizing|dobj|epitopes epitopes|nmod|chain chain|compound|END_ENTITY	Human T cell autoimmunity against myelin_basic_protein : CD4 + cells recognizing epitopes of the T_cell_receptor beta chain from a myelin_basic_protein-specific T cell clone .
7688792	0	CD4	63,66	T_cell_receptor	19,34	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY peptide-specific|dobj|cells peptide-specific|nsubj|involvement involvement|nmod|END_ENTITY	The involvement of T_cell_receptor peptide-specific regulatory CD4 + T cells in recovery from antigen-induced autoimmune_disease .
7737291	0	CD4	60,63	T_cell_receptor	12,27	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY mice|acl|lacking targeting|nmod|mice END_ENTITY|acl|targeting	Intrathymic T_cell_receptor -LRB- TcR -RRB- targeting in mice lacking CD4 or major histocompatibility complex -LRB- MHC -RRB- class II : rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II .
8000034	0	CD4	93,96	T_cell_receptor	30,45	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	thymocytes|compound|START_ENTITY precommitment|nmod|thymocytes evidence|nmod|precommitment commitment|dep|evidence commitment|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	CD4/CD8 lineage commitment in T_cell_receptor transgenic_mice : evidence for precommitment of CD4 + CD8 + thymocytes .
8920851	0	CD4	49,52	T_cell_receptor	16,31	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inactivation of T_cell_receptor peptide-specific CD4 regulatory T cells induces chronic experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
9341751	0	CD4	73,76	T_cell_receptor	14,29	CD4	T cell receptor	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY selection|nmod|cells signals|dobj|selection signals|nsubj|END_ENTITY	Two separable T_cell_receptor signals reconstitute positive selection of CD4 lineage T cells in vivo .
2143170	0	CD4	89,92	TcR	40,43	CD4	TcR	920	6962	Gene	Gene	CD8|compound|START_ENTITY expression|nmod|CD8 expression|compound|END_ENTITY	Patterns of membrane TcR alpha beta and TcR gamma delta chain expression by normal blood CD4 + CD8 - , CD4-CD8 + , CD4-CD8dim + and CD4-CD8 - lymphocytes .
7737291	0	CD4	60,63	TcR	29,32	CD4	TcR	12504(Tax:10090)	328483(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY mice|acl|lacking targeting|nmod|mice T_cell_receptor|acl|targeting T_cell_receptor|appos|END_ENTITY	Intrathymic T_cell_receptor -LRB- TcR -RRB- targeting in mice lacking CD4 or major histocompatibility complex -LRB- MHC -RRB- class II : rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II .
1533311	0	CD4	38,41	TcR-alpha	48,57	CD4	TcR-alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|CD8 CD8|dep|cells cells|amod|END_ENTITY	Characterization and function of CD3 + CD4 - CD8 - TcR-alpha beta bearing cells infiltrating the lung during the immune response .
8567401	0	CD4	70,73	TcR_alpha	53,62	CD4	TcR alpha	12504(Tax:10090)	21473(Tax:10090)	Gene	Gene	+|appos|START_ENTITY END_ENTITY|dep|+	Frequent development of murine T-cell_lymphomas with TcR_alpha / beta + , CD4 - / 8 - phenotype after implantation of human inflammatory_breast_cancer cells in BALB/c nude_mice .
15016653	0	CD4	86,89	Tgf-beta1	44,53	CD4	Tgf-beta1	12504(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells inflammation|nmod|suppression inflammation|nmod|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
10603388	0	CD4	15,18	Th1	22,25	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY END_ENTITY|nsubj|Involvement	Involvement of CD4 -LRB- + -RRB- Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma_cruzi .
10725710	0	CD4	22,25	Th1	46,49	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	Polarization|nmod|START_ENTITY +|nsubj|Polarization +|nmod|subset subset|amod|END_ENTITY	Polarization of naive CD4 + T cells toward the Th1 subset by CTLA-4 costimulation .
10813277	0	CD4	45,48	Th1	12,15	CD4	Th1	920	51497	Gene	Gene	+|compound|START_ENTITY expressing|dobj|+ cytokines|xcomp|expressing cytokines|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of Th1 and Th2 cytokines expressing CD4 + and CD8 + T cells in rheumatoid_arthritis by flow cytometry .
10886511	0	CD4	35,38	Th1	80,83	CD4	Th1	920	51497	Gene	Gene	clones|compound|START_ENTITY display|nsubj|clones display|dobj|profile profile|amod|END_ENTITY	Cutaneous_T_cell_lymphoma reactive CD4 + cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis .
11037819	0	CD4	48,51	Th1	24,27	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|compound|START_ENTITY efficacy|dep|+ efficacy|nmod|END_ENTITY	Therapeutic efficacy of Th1 and Th2 L-selectin -- CD4 + tumor-reactive T cells .
11091281	0	CD4	68,71	Th1	0,3	CD4	Th1	920	51497	Gene	Gene	+|compound|START_ENTITY expressed|nmod|+ expressed|nsubjpass|pattern pattern|amod|END_ENTITY	Th1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4 + and CD8 + T cells .
11123297	0	CD4	55,58	Th1	24,27	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generated|nmod|cells generated|nsubj|production production|nmod|cells cells|amod|END_ENTITY	IFN-gamma production by Th1 cells generated from naive CD4 + T cells exposed to norepinephrine .
11134187	0	CD4	15,18	Th1	84,87	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nsubj|cells	EBNA1-specific CD4 + T cells in healthy carriers of Epstein-Barr_virus are primarily Th1 in function .
11385621	0	CD4	23,26	Th1	121,124	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|required required|nmod|cells cells|amod|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11385621	0	CD4	39,42	Th1	121,124	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY T|nsubj|CD4 T|ccomp|required required|nmod|cells cells|amod|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11564779	0	CD4	19,22	Th1	126,129	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY obtained|nsubj|cells obtained|nmod|mice mice|acl|tolerized tolerized|nmod|responses responses|amod|END_ENTITY	TGF-beta-producing CD4 + mediastinal lymph node cells obtained from mice tracheally tolerized to ovalbumin -LRB- OVA -RRB- suppress both Th1 - and Th2-induced cutaneous inflammatory responses to OVA by different mechanisms .
12055209	0	CD4	146,149	Th1	151,154	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	T and B cell recovery in arthritis adoptively transferred to SCID mice : antigen-specific activation is required for restoration of autopathogenic CD4 + Th1 cells in a syngeneic system .
12365717	0	CD4	0,3	Th1	58,61	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|xcomp|cause cause|advcl|releasing releasing|dobj|cytokines cytokines|amod|END_ENTITY	CD4 T lymphocytes cause hepatocyte apoptosis by releasing Th1 cytokines in cellular immunological liver_injury .
12391214	0	CD4	16,19	Th1	98,101	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY deficient|nsubj|cells deficient|nmod|development development|nmod|function function|amod|END_ENTITY	Murine neonatal CD4 + lymph node cells are highly deficient in the development of antigen-specific Th1 function in adoptive adult hosts .
12444170	0	CD4	62,65	Th1	28,31	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY Th2|acl:relcl|cell END_ENTITY|dep|Th2	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12496424	0	CD4	0,3	Th1	71,74	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|suppress suppress|dobj|differentiation differentiation|nmod|END_ENTITY	CD4 + CD25 + regulatory T cells suppress differentiation and functions of Th1 and Th2 cells , Leishmania_major_infection , and colitis in mice .
12763522	0	CD4	0,3	Th1	32,35	CD4	Th1	920	51497	Gene	Gene	memory|compound|START_ENTITY memory|dep|enigma enigma|nmod|cells cells|amod|END_ENTITY	CD4 + cell memory : the enigma of Th1 cells .
12807487	0	CD4	119,122	Th1	148,151	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY deviates|dobj|cells deviates|nmod|Th2 Th2|nmod|response response|amod|END_ENTITY	Induction of interleukin-12 production in mouse macrophages by berberine , a benzodioxoloquinolizine_alkaloid , deviates CD4 + T cells from a Th2 to a Th1 response .
1345789	0	CD4	60,63	Th1	82,85	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells ligation|nmod|differentiation ligation|nmod|END_ENTITY	Central role for TCR/CD3 ligation in the differentiation of CD4 + T cells toward A Th1 or Th2 functional phenotype .
1345823	0	CD4	54,57	Th1	0,3	CD4	Th1	920	51497	Gene	Gene	profiles|nmod|START_ENTITY profiles|amod|END_ENTITY	Th1 lymphokine production profiles of nickel-specific CD4 + T-lymphocyte clones from nickel contact allergic and non-allergic individuals .
1355013	0	CD4	33,36	Th1	19,22	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells subset|amod|END_ENTITY	Involvement of the Th1 subset of CD4 + T cells in acquired immunity to mouse_infection with Trypanosoma equiperdum .
1355502	0	CD4	25,28	Th1	29,32	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	clones|nummod|START_ENTITY clones|amod|END_ENTITY	The cytotoxic process of CD4 Th1 clones .
14607905	0	CD4	73,76	Th1	69,72	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY immunity|compound|END_ENTITY	CD8alpha + and CD11b + dendritic cell-restricted MHC class II controls Th1 CD4 + T cell immunity .
14634090	0	CD4	81,84	Th1	85,88	CD4	Th1	920	51497	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	MHC class II-peptide complexes in dendritic cell lipid microdomains initiate the CD4 Th1 phenotype .
15128911	0	CD4	35,38	Th1	40,43	CD4	Th1	920	51497	Gene	Gene	inflammation|compound|START_ENTITY inflammation|compound|END_ENTITY	Biliary_atresia is associated with CD4 + Th1 cell-mediated portal tract inflammation .
15150429	0	CD4	19,22	Th1	41,44	CD4	Th1	920	51497	Gene	Gene	entry|nmod|START_ENTITY +|nsubj|entry +|nmod|pathway pathway|amod|END_ENTITY	Increased entry of CD4 + T cells into the Th1 cytokine effector pathway during T-cell division following stimulation in Behcet 's _ disease .
15240714	0	CD4	5,8	Th1	88,91	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY contribute|nsubj|cells contribute|xcomp|Th2 Th2|advcl|suppressing suppressing|dobj|development development|amod|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15271903	0	CD4	0,3	Th1	5,8	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	CD4 + Th1 cells induced by dendritic cell-based immunotherapy in mice chronically infected with Leishmania amazonensis do not promote healing .
15556683	0	CD4	138,141	Th1	75,78	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells END_ENTITY|nmod|differentiation	Endogenous IL-4 and IFN-gamma are essential for expression of Th2 , but not Th1 cytokine message during the early differentiation of human CD4 + T helper cells .
15778385	0	CD4	14,17	Th1	19,22	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	Early role of CD4 + Th1 cells and antibodies in HER-2 adenovirus vaccine protection against autochthonous mammary carcinomas .
15789061	0	CD4	9,12	Th1	14,17	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	effect|compound|START_ENTITY effect|amod|END_ENTITY	Combined CD4 + Th1 effect and lymphotactin transgene expression enhance CD8 + Tc1 tumor localization and therapy .
15789359	0	CD4	33,36	Th1	29,32	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	HSV induces an early primary Th1 CD4 T cell response in neonatal mice , but reduced CTL activity at the time of the peak adult response .
15814278	0	CD4	16,19	Th1	122,125	CD4	Th1	920	51497	Gene	Gene	+|compound|START_ENTITY Contribution|nmod|+ T|nsubj|Contribution T|parataxis|mediates mediates|nsubj|response response|amod|END_ENTITY	Contribution of CD4 + and CD8 + T cells and interferon-gamma to the progress of chronic rejection of kidney allografts : the Th1 response mediates both acute and chronic rejection .
15885644	0	CD4	6,9	Th1	11,14	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|participate participate|nsubj|cells cells|amod|END_ENTITY	Armed CD4 + Th1 effector cells and activated macrophages participate in bile_duct_injury in murine biliary_atresia .
16272312	0	CD4	48,51	Th1	53,56	CD4	Th1	920	51497	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Sphingosine_kinase_1 is a negative regulator of CD4 + Th1 cells .
16424184	0	CD4	24,27	Th1	83,86	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Responsiveness|nmod|cells determines|nsubj|Responsiveness determines|dobj|ratio ratio|nmod|END_ENTITY	Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation .
16725235	0	CD4	89,92	Th1	8,11	CD4	Th1	920	51497	Gene	Gene	responses|nsubj|START_ENTITY enhances|xcomp|responses CLIP|ccomp|enhances CLIP|nsubj|vaccine vaccine|compound|END_ENTITY	HCV-NS3 Th1 minigene vaccine based on invariant chain CLIP genetic substitution enhances CD4 -LRB- + -RRB- Th1 cell responses in vivo .
16725235	0	CD4	89,92	Th1	96,99	CD4	Th1	920	51497	Gene	Gene	responses|nsubj|START_ENTITY responses|amod|END_ENTITY	HCV-NS3 Th1 minigene vaccine based on invariant chain CLIP genetic substitution enhances CD4 -LRB- + -RRB- Th1 cell responses in vivo .
16729885	0	CD4	36,39	Th1	41,44	CD4	Th1	920	51497	Gene	Gene	inflammation|compound|START_ENTITY inflammation|compound|END_ENTITY	Production of IL-16 correlates with CD4 + Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple_sclerosis_lesions .
16730774	0	CD4	46,49	Th1	51,54	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	CD1d expression on hemopoietic cells promotes CD4 + Th1 response in coxsackievirus B3 induced myocarditis .
1680917	0	CD4	23,26	Th1	77,80	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	T|compound|START_ENTITY IL-10|nmod|T lymphocytes|amod|IL-10 Production|nmod|lymphocytes correlates|nsubj|Production correlates|nmod|down-regulation down-regulation|nmod|synthesis synthesis|amod|END_ENTITY	Production of IL-10 by CD4 + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth_infection .
1682389	0	CD4	24,27	Th1	29,32	CD4	Th1	920	51497	Gene	Gene	cytotoxicity|nmod|START_ENTITY +|nsubj|cytotoxicity +|dobj|clones clones|amod|END_ENTITY	A novel cytotoxicity of CD4 + Th1 clones on heat-shocked_tumor targets .
16998360	0	CD4	10,13	Th1	88,91	CD4	Th1	920	51497	Gene	Gene	activity|compound|START_ENTITY depresses|nsubj|activity depresses|dobj|immunity immunity|amod|END_ENTITY	Increased CD4 + CD25 + T regulatory cell activity in trauma patients depresses protective Th1 immunity .
17081623	0	CD4	0,3	Th1	73,76	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY enriched|nsubjpass|cells enriched|nmod|markers markers|amod|END_ENTITY	CD4 -LRB- + -RRB- memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple_sclerosis .
17135575	0	CD4	77,80	Th1	33,36	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY effector|nmod|cells effector|nsubj|END_ENTITY	Prostaglandin_I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells .
17274112	0	CD4	0,3	Th1	5,8	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + Th1 cells promote CD8 + Tc1 cell survival , memory response , tumor localization and therapy by targeted delivery of interleukin_2 via acquired pMHC I complexes .
17563757	0	CD4	18,21	Th1	69,72	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Downregulation|nmod|cells underlie|nsubj|Downregulation underlie|dobj|immunity immunity|amod|END_ENTITY	Downregulation of CD4 + CD25 + regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells .
17805015	0	CD4	20,23	Th1	0,3	CD4	Th1	920	51497	Gene	Gene	+|compound|START_ENTITY polarization|nmod|+ polarization|amod|END_ENTITY	Th1 polarization of CD4 + T cells by Toll-like receptor 3-activated human microglia .
17881511	0	CD4	80,83	Th1	57,60	CD4	Th1	920	51497	Gene	Gene	cells|nummod|START_ENTITY differentiation|nmod|cells differentiation|amod|END_ENTITY	HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4 + T cells via suppression of dendritic cell IL-12 production .
18606658	0	CD4	0,3	Th1	95,98	CD4	Th1	920	51497	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|acl|transduced transduced|xcomp|express express|ccomp|synthesize synthesize|dobj|cytokines cytokines|amod|END_ENTITY	CD4 + CD25 - T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model .
19029829	0	CD4	13,16	Th1	107,110	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Depletion|nmod|CD25 induces|nsubj|Depletion induces|dobj|response response|amod|END_ENTITY	Depletion of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- regulatory T cells from tumor infiltrating lymphocytes predominantly induces Th1 type immune response in vivo which inhibits tumor growth in adoptive immunotherapy .
19293635	0	CD4	39,42	Th1	46,49	CD4	Th1	920	51497	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
19564349	0	CD4	83,86	Th1	88,91	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY immunity|compound|END_ENTITY	Dendritic_cells require a systemic type I interferon response to mature and induce CD4 + Th1 immunity with poly IC as adjuvant .
19596772	0	CD4	43,46	Th1	48,51	CD4	Th1	920	51497	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	CT043 , a protective antigen that induces a CD4 + Th1 response during Chlamydia_trachomatis_infection in mice and humans .
19670379	0	CD4	73,76	Th1	254,257	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY osteopontin|nmod|Cells production|nmod|osteopontin IFN-beta|nmod|production effects|nmod|IFN-beta serves|nsubj|effects serves|ccomp|reported reported|advcl|involving involving|nmod|END_ENTITY	Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4 + T Cells in MS. IFN-beta currently serves as one of the major treatments for MS. Its anti-inflammatory mechanism has been reported as involving a shift in cytokine balance from Th1 to Th2 in the T-cell response against elements of the myelin sheath .
1972170	0	CD4	39,42	Th1	55,58	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY +|nsubj|Characterization +|nmod|cells cells|amod|END_ENTITY	Characterization of tumor-infiltrating CD4 + T cells as Th1 cells based on lymphokine secretion and functional properties .
19726768	0	CD4	108,111	Th1	112,115	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tuberculosis-associated_immune_restoration_syndrome in HIV-1-infected patients involves tuberculin-specific CD4 Th1 cells and KIR-negative gammadelta T cells .
19781678	0	CD4	105,108	Th1	101,104	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4 + cells and strong antibody responses in mice .
20128236	0	CD4	0,3	Th1	62,65	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|ccomp|prevent prevent|dobj|development development|nmod|response response|amod|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium_yoelii infection in susceptible BALB/c mice .
20888363	0	CD4	102,105	Th1	45,48	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY state|nmod|activation stem|nmod|state stem|dobj|cells cells|nmod|END_ENTITY	Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4 + T cell activation .
21172925	0	CD4	152,155	Th1	148,151	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Analysis of immune reconstitution after autologous CD34 + stem/progenitor cell transplantation for systemic sclerosis : predominant reconstitution of Th1 CD4 + T cells .
21270829	0	CD4	114,117	Th1	137,140	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY ve|dobj|cells ve|nmod|END_ENTITY	Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of na ve CD4 T cells toward the Th1 , Th2 and Th17 lineages .
21600260	0	CD4	94,97	Th1	90,93	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|dep|cells	Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4 + cells and strong mucosal and systemic antibody responses in mice .
21646911	0	CD4	37,40	Th1	83,86	CD4	Th1	920	51497	Gene	Gene	response|nsubj|START_ENTITY response|advcl|reducing reducing|dobj|cytokines cytokines|amod|END_ENTITY	HIV-1_infection impairs HSV-specific CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T-cell response by reducing Th1 cytokines and CCR5 ligand secretion .
21655295	0	CD4	36,39	Th1	86,89	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells modulates|nsubj|expression modulates|dobj|granulomatous_lung_inflammation granulomatous_lung_inflammation|amod|END_ENTITY	Dysregulated cytokine expression by CD4 + T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous_lung_inflammation .
21984703	0	CD4	27,30	Th1	70,73	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY develop|nsubj|cells develop|ccomp|cytokine cytokine|nsubj|independent independent|nmod|END_ENTITY	Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis .
22302060	0	CD4	96,99	Th1	12,15	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY increase|nmod|cells lacking|nsubj|increase drives|advcl|lacking drives|dobj|production production|amod|END_ENTITY	IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Ra .
23064187	0	CD4	0,3	Th1	5,8	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + Th1 cells are effectors in lupus_nephritis -- but what are their targets ?
23630349	0	CD4	12,15	Th1	65,68	CD4	Th1	920	51497	Gene	Gene	priming|compound|START_ENTITY Location|nmod|priming regulates|nsubj|Location regulates|dobj|differentiation differentiation|nmod|cells cells|amod|END_ENTITY	Location of CD4 + T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis .
23715742	0	CD4	0,3	Th1	59,62	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY affects|nsubj|IL-2 affects|dobj|END_ENTITY	CD4 T cell-intrinsic IL-2 signaling differentially affects Th1 and Th17 development .
23734780	0	CD4	34,37	Th1	117,120	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	population|compound|START_ENTITY generate|dobj|population generate|nmod|process process|nmod|cells cells|amod|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
24197135	0	CD4	14,17	Th1	29,32	CD4	Th1	920	51497	Gene	Gene	NKG2D|compound|START_ENTITY Regulation|nmod|NKG2D cells|compound|Regulation cells|amod|END_ENTITY	Regulation of CD4 -LRB- + -RRB- NKG2D -LRB- + -RRB- Th1 cells in patients with metastatic_melanoma treated with sorafenib : role of IL-15Ra and NKG2D triggering .
24489707	0	CD4	40,43	Th1	56,59	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY polarization|nmod|cells modulate|dobj|polarization modulate|nmod|cells cells|amod|END_ENTITY	Astrocytes modulate the polarization of CD4 + T cells to Th1 cells .
24799699	0	CD4	52,55	Th1	56,59	CD4	Th1	920	51497	Gene	Gene	immunity|compound|START_ENTITY immunity|compound|END_ENTITY	Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral_infection .
25740946	0	CD4	46,49	Th1	99,102	CD4	Th1	920	51497	Gene	Gene	Origin|compound|START_ENTITY Origin|nmod|Cells Cells|compound|END_ENTITY	Demethylation of the RORC2 and IL17A in Human CD4 + T Lymphocytes Defines Th17 Origin of Nonclassic Th1 Cells .
26056253	0	CD4	77,80	Th1	56,59	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Memory|dobj|Cells Memory|nsubj|Development Development|nmod|Cavity Cavity|nmod|END_ENTITY	Early Development in the Peritoneal Cavity of CD49dhigh Th1 Memory Phenotype CD4 + T Cells with Enhanced B Cell Helper Activity .
7495735	0	CD4	4,7	Th1	9,12	CD4	Th1	920	51497	Gene	Gene	+|compound|START_ENTITY +|dep|cells cells|amod|END_ENTITY	Are CD4 + Th1 cells pro-inflammatory or anti-inflammatory ?
7538051	0	CD4	40,43	Th1	15,18	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	fraction|compound|START_ENTITY +|dobj|fraction +|nsubj|Enrichment Enrichment|nmod|cells cells|amod|END_ENTITY	Enrichment for Th1 cells in the Mel-14 + CD4 + T cell fraction in aged mice .
7541726	0	CD4	57,60	Th1	62,65	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cytotoxicity|nmod|START_ENTITY mechanism|nmod|cytotoxicity +|nsubj|mechanism +|dobj|clones clones|amod|END_ENTITY	The molecular mechanism of FasL-mediated cytotoxicity by CD4 + Th1 clones .
7561083	0	CD4	68,71	Th1	38,41	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	T|compound|START_ENTITY development|nmod|T development|amod|END_ENTITY	Opposing effects of TGF-beta_2 on the Th1 cell development of naive CD4 + T cells isolated from different mouse strains .
7600284	0	CD4	105,108	Th1	14,17	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reconstituted|nmod|cells mice|acl|reconstituted inflammatory_bowel_disease|nmod|mice prevents|xcomp|inflammatory_bowel_disease prevents|nsubj|Inhibition Inhibition|nmod|responses responses|amod|END_ENTITY	Inhibition of Th1 responses prevents inflammatory_bowel_disease in scid mice reconstituted with CD45RBhi CD4 + T cells .
7699320	0	CD4	20,23	Th1	25,28	CD4	Th1	12504(Tax:10090)	51497	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|mediate mediate|nsubj|clones clones|amod|END_ENTITY	Poliovirus-specific CD4 + Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic_mice expressing the human poliovirus receptor .
7730613	0	CD4	81,84	Th1	60,63	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nmod|cells produce|dobj|development development|nmod|cells cells|amod|END_ENTITY	Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4 + T cells .
7930573	0	CD4	32,35	Th1	67,70	CD4	Th1	920	51497	Gene	Gene	cell|compound|START_ENTITY develop|nsubj|cell develop|nmod|END_ENTITY	Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype .
8020550	0	CD4	12,15	Th1	0,3	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	specific|compound|START_ENTITY specific|compound|END_ENTITY	Th1 and Th2 CD4 + T cell clones specific for Plasmodium_chabaudi but not for an unrelated antigen protect against blood stage P. _ chabaudi infection .
8098671	0	CD4	14,17	Th1	59,62	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|nummod|START_ENTITY functional|nmod:npmod|+ responses|amod|functional responses|nmod|dose dose|nmod|END_ENTITY	Separation of CD4 + functional responses by peptide dose in Th1 and Th2 subsets expressing the same transgenic antigen receptor .
8100844	0	CD4	39,42	Th1	27,30	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Differential activation of Th1 and Th2 CD4 + cells by murine brain microvessel endothelial cells and smooth muscle/pericytes .
8260458	0	CD4	109,112	Th1	68,71	CD4	Th1	920	51497	Gene	Gene	CD8|compound|START_ENTITY production|nmod|CD8 production|amod|END_ENTITY	Function of alpha beta TCR + intestinal intraepithelial lymphocytes : Th1 - and Th2-type cytokine production by CD4 + CD8 - and CD4 + CD8 + T cells for helper activity .
8606068	0	CD4	14,17	Th1	19,22	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|amod|END_ENTITY	Transfer of a CD4 + Th1 cell line to nude_mice effects clearance of Rhodococcus_equi from the lung .
8608641	0	CD4	49,52	Th1	9,12	CD4	Th1	920	51497	Gene	Gene	expression|nmod|START_ENTITY cytokine|dobj|expression cytokine|nsubj|END_ENTITY	Selected Th1 and Th2 cytokine mRNA expression by CD4 -LRB- + -RRB- T cells isolated from inflamed human gingival tissues .
8658054	0	CD4	27,30	Th1	32,35	CD4	Th1	920	51497	Gene	Gene	Activation|nmod|START_ENTITY +|nsubj|Activation +|dobj|cells cells|amod|END_ENTITY	Activation of cloned human CD4 + Th1 and Th2 cells by blood dendritic cells .
8698378	0	CD4	91,94	Th1	47,50	CD4	Th1	920	51497	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
8707335	0	CD4	62,65	Th1	89,92	CD4	Th1	920	51497	Gene	Gene	maturation|compound|START_ENTITY lost|nmod|maturation lost|nmod|END_ENTITY	CD31 -LRB- PECAM-1 -RRB- is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells .
8748254	0	CD4	41,44	Th1	32,35	CD4	Th1	920	51497	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Mycobacterium bovis BCG-induced Th1 type CD4 + suppressor T cells act by suppressing IL-2 production and IL-2_receptor expression .
8752903	0	CD4	25,28	Th1	0,3	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells development|amod|END_ENTITY	Th1 development of naive CD4 + T cells is inhibited by co-activation with anti-CD4 monoclonal antibodies .
8977227	0	CD4	56,59	Th1	89,92	CD4	Th1	920	51497	Gene	Gene	counts|compound|START_ENTITY multidrug-resistant_tuberculosis|nmod|counts Patients|nmod|multidrug-resistant_tuberculosis impaired|nsubj|Patients impaired|dobj|responses responses|amod|END_ENTITY	Patients with multidrug-resistant_tuberculosis with low CD4 + T cell counts have impaired Th1 responses .
9095259	0	CD4	21,24	Th1	36,39	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	direction|nmod|START_ENTITY T|nmod|direction T|nmod|END_ENTITY	In vivo direction of CD4 T cells to Th1 and Th2-like patterns of cytokine synthesis .
9178644	0	CD4	4,7	Th1	0,3	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Th1 CD4 + cells adoptively transfer experimental hypersensitivity_pneumonitis .
9521080	0	CD4	46,49	Th1	51,54	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|acl:relcl|mediates mediates|nsubj|cells cells|amod|END_ENTITY	A T cell activation antigen , Ly6C , induced on CD4 + Th1 cells mediates an inhibitory signal for secretion of IL-2 and proliferation in peripheral immune responses .
9579368	0	CD4	121,124	Th1	103,106	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY commitment|nmod|cells commitment|amod|END_ENTITY	Cyclophosphamide given after active specific immunization augments antitumor immunity by modulation of Th1 commitment of CD4 + T cells .
9627004	0	CD4	31,34	Th1	0,3	CD4	Th1	920	51497	Gene	Gene	+|compound|START_ENTITY cytokines|nmod|+ cytokines|amod|END_ENTITY	Th1 - and Th2-like cytokines in CD4 + and CD8 + T cells in autism .
9680328	0	CD4	119,122	Th1	146,149	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY differentiation|nmod|T-cells activation|nmod|differentiation activation|nmod|END_ENTITY	Reprogramming the signalling requirement for AP-1 _ -LRB- activator_protein-1 -RRB- activation during differentiation of precursor CD4 + T-cells into effector Th1 and Th2 cells .
9780149	0	CD4	61,64	Th1	85,88	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	effectors|nummod|START_ENTITY effectors|acl|secreting secreting|dobj|END_ENTITY	High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines .
9806643	0	CD4	19,22	Th1	35,38	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	Differentiation of CD4 + T cells to Th1 cells requires MAP kinase JNK2 .
9818646	0	CD4	169,172	Th1	13,16	CD4	Th1	920	51497	Gene	Gene	humanized|nmod|START_ENTITY humanized|nsubj|Reduction Reduction|nmod|activity activity|amod|END_ENTITY	Reduction of Th1 cell activity in the peripheral circulation of patients with rheumatoid_arthritis after treatment with a non-depleting humanized monoclonal antibody to CD4 .
9831181	0	CD4	35,38	Th1	90,93	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|mice mice|nmod|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
9848681	0	CD4	129,132	Th1	134,137	CD4	Th1	920	51497	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Isolation of recombinant phage clones expressing mycobacterial T cell antigens by screening a recombinant DNA library with human CD4 + Th1 clones .
9889959	0	CD4	38,41	Th1	43,46	CD4	Th1	12504(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Anti-leishmania effector functions of CD4 + Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania_major in BALB/c mice .
10598017	0	CD4	24,27	Th2	85,88	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY produce|nsubj|cells produce|advcl|produce produce|ccomp|cytokines cytokines|nsubj|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
10598017	0	CD4	66,69	Th2	85,88	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|ccomp|cytokines cytokines|nsubj|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
10706693	0	CD4	123,126	Th2	147,150	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ development|nmod|lymphocytes required|nmod|development required|nmod|profile profile|amod|END_ENTITY	Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4 + lymphocytes with a Th2 cytokine profile .
10859331	0	CD4	151,154	Th2	221,224	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells changes|dobj|differentiation Alteration|dep|changes Alteration|nsubj|Th1 Th1|nmod|END_ENTITY	Alteration at a single amino_acid residue in the T_cell_receptor_alpha_chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 -LRB- Th1 -RRB- to Th2 .
10940889	0	CD4	144,147	Th2	66,69	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells induce|dep|expression induce|nmod|induction induction|compound|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
10946291	0	CD4	71,74	Th2	76,79	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	An immunomodulatory function for neutrophils during the induction of a CD4 + Th2 response in BALB/c mice infected with Leishmania_major .
11034364	0	CD4	20,23	Th2	74,77	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	naive|dep|START_ENTITY cells|amod|naive provide|nsubj|cells provide|nmod|differentiation differentiation|amod|END_ENTITY	Conventional , naive CD4 + T cells provide an initial source of IL-4 during Th2 differentiation .
11093173	0	CD4	63,66	Th2	81,84	CD4	Th2	920	15111(Tax:10090)	Gene	Gene	cutaneous_lymphocyte-associated_antigen|nmod|START_ENTITY cells|amod|cutaneous_lymphocyte-associated_antigen cells|amod|END_ENTITY	Expression of cutaneous_lymphocyte-associated_antigen on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- Th2 cells .
11385621	0	CD4	23,26	Th2	109,112	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|required required|nmod|generation generation|nmod|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11385621	0	CD4	39,42	Th2	109,112	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY T|nsubj|CD4 T|ccomp|required required|nmod|generation generation|nmod|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11588111	0	CD4	96,99	Th2	131,134	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	T|nsubj|START_ENTITY T|nmod|Th1 Th1|nmod|pathway pathway|amod|END_ENTITY	Inhibition of interleukin-12 production by auranofin , an anti-rheumatic gold compound , deviates CD4 -LRB- + -RRB- T cells from the Th1 to the Th2 pathway .
11673504	0	CD4	59,62	Th2	104,107	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	T|compound|START_ENTITY effect|nmod|T effect|acl|enhance enhance|dobj|development development|nmod|cells cells|amod|END_ENTITY	1alpha,25-Dihydroxyvitamin _ d3 has a direct effect on naive CD4 -LRB- + -RRB- T cells to enhance the development of Th2 cells .
11801634	0	CD4	0,3	Th2	38,41	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|selected selected|nmod|conditions conditions|amod|END_ENTITY	CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3 .
11981831	0	CD4	36,39	Th2	87,90	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	acts|compound|START_ENTITY secreted|nmod|acts secreted|xcomp|induce induce|dobj|differentiation differentiation|amod|END_ENTITY	IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation .
12165514	0	CD4	111,114	Th2	33,36	CD4	Th2	920	15111(Tax:10090)	Gene	Gene	T|compound|START_ENTITY hypersensitive|nmod|T hypersensitive|dep|cytokine cytokine|nsubj|changes changes|nmod|END_ENTITY	DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4 -LRB- + -RRB- T cell differentiation .
12207329	0	CD4	31,34	Th2	44,47	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	T1/ST2|compound|START_ENTITY distribution|nmod|T1/ST2 +|nsubj|distribution +|dobj|cells cells|amod|END_ENTITY	Organ-specific distribution of CD4 + T1/ST2 + Th2 cells in Leishmania_major_infection .
12444170	0	CD4	62,65	Th2	32,35	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|acl:relcl|cell	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12538670	0	CD4	81,84	Th2	69,72	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY bias|nmod|lymphocytes bias|amod|END_ENTITY	Deregulated MHC_class_II transactivator expression leads to a strong Th2 bias in CD4 + T lymphocytes .
12807487	0	CD4	119,122	Th2	139,142	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY deviates|dobj|cells deviates|nmod|END_ENTITY	Induction of interleukin-12 production in mouse macrophages by berberine , a benzodioxoloquinolizine_alkaloid , deviates CD4 + T cells from a Th2 to a Th1 response .
12835475	0	CD4	69,72	Th2	91,94	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells inhibits|dobj|differentiation inhibits|nmod|lineage lineage|amod|END_ENTITY	The Runx1 transcription factor inhibits the differentiation of naive CD4 + T cells into the Th2 lineage by repressing GATA3 expression .
1347553	0	CD4	0,3	Th2	5,8	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	CD4 + Th2 response induced by Schistosoma_mansoni eggs develops rapidly , through an early , transient , Th0-like stage .
14991598	0	CD4	92,95	Th2	76,79	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Pinpointing|nmod|cells Pinpointing|dobj|acquisition acquisition|nmod|activity activity|amod|END_ENTITY	Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells .
15004191	0	CD4	0,3	Th2	78,81	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|regulate regulate|advcl|modulating modulating|dobj|phenotype phenotype|amod|END_ENTITY	CD4 + CD25 + T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype .
15240714	0	CD4	5,8	Th2	30,33	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY contribute|nsubj|cells contribute|xcomp|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15388256	0	CD4	124,127	Th2	44,47	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	+|compound|START_ENTITY increase|nmod|+ characterized|nmod|increase infection|acl|characterized responses|nmod|infection responses|amod|END_ENTITY	The absence of IFN-gamma leads to increased Th2 responses after influenza_A_virus infection characterized by an increase in CD4 + but not CD8 + T cells producing IL-4 or IL-5 in the lung .
15714582	0	CD4	28,31	Th2	111,114	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY mediated|nmod|cells rejection|acl|mediated associated|nsubjpass|rejection associated|nmod|response response|amod|END_ENTITY	Graft rejection mediated by CD4 + T cells via indirect recognition of alloantigen is associated with a dominant Th2 response .
15876426	0	CD4	41,44	Th2	64,67	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY directs|dobj|cells directs|xcomp|produce produce|dobj|cytokines cytokines|amod|END_ENTITY	Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus .
17312108	0	CD4	16,19	Th2	48,51	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY poised|nsubjpass|cells poised|nmod|function function|amod|END_ENTITY	Murine neonatal CD4 + cells are poised for rapid Th2 effector-like function .
17785819	0	CD4	42,45	Th2	82,85	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	development|nmod|START_ENTITY cells|nmod|development role|nmod|cells effector|nsubj|role effector|nmod|response response|amod|END_ENTITY	The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response .
18836070	0	CD4	117,120	Th2	74,77	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|nmod|cytokines cytokines|amod|END_ENTITY	Interferon_regulatory_factor_4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4 + T cells .
19264621	0	CD4	39,42	Th2	44,47	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Japanese_encephalitis_virus produces a CD4 + Th2 response and associated immunoprotection in an adoptive-transfer murine model .
21469117	0	CD4	42,45	Th2	60,63	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Selective effects of NF-kB1 deficiency in CD4 T cells on Th2 and TFh induction by alum-precipitated protein vaccines .
22424785	0	CD4	0,3	Th2	5,8	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene .
23047087	0	CD4	71,74	Th2	94,97	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiating|dobj|cells differentiating|nmod|END_ENTITY	Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4 T cells into the Th2 or Th1 phenotype .
23052013	0	CD4	0,3	Th2	31,34	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	Lymphocytes|compound|START_ENTITY Lymphocytes|appos|cells cells|amod|END_ENTITY	CD4 + T Lymphocytes , especially Th2 cells , contribute to the progress of renal_fibrosis .
24769377	0	CD4	108,111	Th2	74,77	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	Foxp3|amod|START_ENTITY Effects|nmod|Foxp3 Effects|nmod|Lactobacillus_rhamnosus Lactobacillus_rhamnosus|nmod|model model|nmod|Th17 Th17|compound|END_ENTITY	Effects of Lactobacillus_rhamnosus on allergic march model by suppressing Th2 , Th17 , and TSLP responses via CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Tregs .
7743677	0	CD4	75,78	Th2	44,47	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY generation|nmod|cells MHC-specific|nmod|generation MHC-specific|dobj|cells cells|amod|END_ENTITY	The influence of allo-class II MHC-specific Th2 cells on the generation of CD4 and CD8 cytotoxic T cells to associated class I and class II MHC alloantigen .
7908325	0	CD4	0,3	Th2	35,38	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|pathway pathway|amod|END_ENTITY	CD4 + effector cells default to the Th2 pathway in interferon_gamma-deficient mice infected with Leishmania_major .
8525520	0	CD4	0,3	Th2	4,7	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 Th2 cells do not functionally suppress CTL generation in neonatal tolerant mice .
8613355	0	CD4	123,126	Th2	128,131	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
9043951	0	CD4	35,38	Th2	15,18	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|compound|START_ENTITY polarization|nmod|response polarization|amod|END_ENTITY	Lack of Th1 or Th2 polarization of CD4 + T cell response induced by particulate antigen targeted to phagocytic cells .
9160750	0	CD4	96,99	Th2	64,67	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells .
9175834	0	CD4	50,53	Th2	9,12	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY Impaired|nmod|absence Impaired|dobj|development development|amod|END_ENTITY	Impaired Th2 subset development in the absence of CD4 .
9378492	0	CD4	45,48	Th2	22,25	CD4	Th2	920	15111(Tax:10090)	Gene	Gene	effector|compound|START_ENTITY cytokines|nmod|effector cytokines|amod|END_ENTITY	Massive production of Th2 cytokines by human CD4 + effector T cells transiently expressing the natural killer cell marker CD57/HNK1 .
9378954	0	CD4	0,3	Th2	5,8	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	CD4 + Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced_arthritis .
9379016	0	CD4	97,100	Th2	102,105	CD4	Th2	12504(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Distinct roles for B7-1_and_B7-2 determinants during priming of effector CD8 + Tc1 and regulatory CD4 + Th2 cells for contact hypersensitivity .
10064055	0	CD4	44,47	Thy-1	26,31	CD4	Thy-1	920	7070	Gene	Gene	+|compound|START_ENTITY antigens|nmod|+ antigens|compound|END_ENTITY	Spontaneous clustering of Thy-1 antigens on CD4 + CD8 + thymocytes lacking TCR engagement by MHC/peptide complexes .
1673982	0	CD4	75,78	Thy-1	45,50	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|dep|- cells|appos|- triple|dobj|cells triple|nsubj|+ +|compound|END_ENTITY	Distinct subsets of accessory cells activate Thy-1 + triple negative -LRB- CD3 - , CD4 - , CD8 - -RRB- cells and Th-1 delayed-type_hypersensitivity effector T cells .
1682394	0	CD4	135,138	Thy-1	128,133	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Resolution of primary murine listeriosis and acquired resistance to lethal secondary infection can be mediated predominantly by Thy-1 + CD4 - CD8 - cells .
1972943	0	CD4	55,58	Thy-1	61,66	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The pineal neurohormone melatonin_stimulates activated CD4 + , Thy-1 + cells to release opioid agonist -LRB- s -RRB- with immunoenhancing and anti-stress properties .
1980114	0	CD4	33,36	Thy-1	54,59	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|lacking lacking|dobj|END_ENTITY	A unique subset of normal murine CD4 + T cells lacking Thy-1 is expanded in a murine retrovirus-induced immunodeficiency_syndrome , MAIDS .
21519344	0	CD4	13,16	Thy-1	57,62	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY Induction|nmod|CD25 Induction|nmod|cells cells|dep|stimulation stimulation|compound|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21519344	0	CD4	78,81	Thy-1	57,62	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
2478617	0	CD4	51,54	Thy-1	19,24	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	-|compound|START_ENTITY double-negative|appos|- double-negative|nsubj|cell cell|compound|END_ENTITY	The DTH-initiating Thy-1 + cell is double-negative -LRB- CD4 - , CD8 - -RRB- and CD3 - , and expresses IL-3 receptors , but no IL-2 receptors .
7507599	0	CD4	23,26	Thy-1	44,49	CD4	Thy-1	12504(Tax:10090)	21838(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY dynamics|nmod|cells dynamics|acl|lacking lacking|dobj|END_ENTITY	Population dynamics of CD4 + T cells lacking Thy-1 in murine retrovirus-induced immunodeficiency_syndrome -LRB- MAIDS -RRB- .
7547688	0	CD4	109,112	Thy-1	26,31	CD4	Thy-1	920	7070	Gene	Gene	cells|nummod|START_ENTITY subset|nmod|cells associated|nmod|subset associated|nsubjpass|activation activation|nmod|END_ENTITY	T cell activation through Thy-1 is associated with the expression of a surface protein -LRB- p100 -RRB- on a subset of CD4 cells .
22438246	0	CD4	52,55	Tim-3	22,27	CD4	Tim-3	920	84868	Gene	Gene	cells|compound|START_ENTITY susceptible|nsubj|cells activated|xcomp|susceptible activated|nsubj|renders renders|amod|END_ENTITY	Galectin-9 binding to Tim-3 renders activated human CD4 + T cells less susceptible to HIV-1_infection .
23161469	0	CD4	31,34	Tim-3	91,96	CD4	Tim-3	920	84868	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 +|nmod|pathway pathway|amod|/ /|amod|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
26064278	0	CD4	25,28	Tim-3	16,21	CD4	Tim-3	920	84868	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Upregulation of Tim-3 on CD4 -LRB- + -RRB- T cells is associated with Th1/Th2 imbalance in patients with allergic_asthma .
26930930	0	CD4	41,44	Tim-3	15,20	CD4	Tim-3	920	84868	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	-LSB- Expression of Tim-3 on peripheral blood CD4 + T cells and its correlation with liver function damage parameters in advanced schistosomiasis patients -RSB- .
12816980	0	CD4	119,122	Toll-like_receptor_2	57,77	CD4	Toll-like receptor 2	920	7097	Gene	Gene	cells|compound|START_ENTITY internalizes|nmod|cells internalizes|csubj|Cutting Cutting|xcomp|END_ENTITY	Cutting edge : link between innate and adaptive immunity : Toll-like_receptor_2 internalizes antigen for presentation to CD4 + T cells and could be an efficient vaccine target .
16632602	0	CD4	58,61	Toll-like_receptor_2	0,20	CD4	Toll-like receptor 2	12504(Tax:10090)	24088(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY functions|nmod|cells modulates|dobj|functions modulates|nsubj|signaling signaling|compound|END_ENTITY	Toll-like_receptor_2 signaling modulates the functions of CD4 + CD25 + regulatory T cells .
19552525	0	CD4	38,41	Toll-like_receptor_2	14,34	CD4	Toll-like receptor 2	920	7097	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Engagement of Toll-like_receptor_2 on CD4 -LRB- + -RRB- T cells facilitates local immune responses in patients with tuberculous_pleurisy .
20434372	0	CD4	34,37	Toll-like_receptor_2	0,20	CD4	Toll-like receptor 2	920	7097	Gene	Gene	T|compound|START_ENTITY signaling|nmod|T END_ENTITY|acl|signaling	Toll-like_receptor_2 signaling in CD4 -LRB- + -RRB- T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune_disease .
26714796	0	CD4	147,150	Toll-like_receptor_2	86,106	CD4	Toll-like receptor 2	12504(Tax:10090)	24088(Tax:10090)	Gene	Gene	influences|dobj|START_ENTITY influences|nsubj|signalling signalling|compound|END_ENTITY	Patency of Litomosoides_sigmodontis_infection depends on Toll-like_receptor_4 whereas Toll-like_receptor_2 signalling influences filarial-specific CD4 -LRB- + -RRB- T-cell responses .
21078852	0	CD4	71,74	Toll-like_receptors_1_and_2	100,127	CD4	Toll-like receptors 1 and 2	920	7096;7097	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Mycobacterium_tuberculosis lipoproteins directly regulate human memory CD4 -LRB- + -RRB- T cell activation via Toll-like_receptors_1_and_2 .
23494522	0	CD4	52,55	Tumor_necrosis_factor	0,21	CD4	Tumor necrosis factor	920	7124	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Tumor_necrosis_factor receptor type I expression of CD4 + T cells in rheumatoid_arthritis enables them to follow tumor_necrosis_factor gradients into the rheumatoid synovium .
23722874	0	CD4	35,38	Tyrosine_hydroxylase	0,20	CD4	Tyrosine hydroxylase	12504(Tax:10090)	21823(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Tyrosine_hydroxylase expression in CD4 -LRB- + -RRB- T cells is associated with joint inflammatory alleviation in collagen_type_II-induced_arthritis .
20705519	0	CD4	44,47	VEGF	36,40	CD4	VEGF	920	7422	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Increased spontaneous production of VEGF by CD4 + T cells in type 1 diabetes .
11108936	0	CD4	61,64	VIP	0,3	CD4	VIP	920	7432	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	VIP and PACAP inhibit Fas_ligand-mediated bystander lysis by CD4 -LRB- + -RRB- T cells .
18534815	0	CD4	115,118	VPAC-1	79,85	CD4	VPAC-1	12504(Tax:10090)	22354(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|appos|END_ENTITY	TCR signaling and environment affect vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- expression in primary mouse CD4 T cells .
18555660	0	CD4	125,128	VPAC-1	100,106	CD4	VPAC-1	12504(Tax:10090)	22354(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Stimulatory and suppressive signal transduction regulates vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- in primary mouse CD4 T cells .
10384104	0	CD4	29,32	Valpha14	20,28	Th2	Valpha14	15111(Tax:10090)	111622(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	A novel function of Valpha14 + CD4 + NKT cells : stimulation of IL-12 production by antigen-presenting cells in the innate immune system .
9716255	0	CD4	27,30	W3/25	12,17	CD4	W3/25	24932(Tax:10116)	24932(Tax:10116)	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Kinetics of W3/25 anti-rat CD4 monoclonal antibody .
22109656	0	CD4	26,29	XAGE-1b	63,70	CD4	XAGE-1b	920	653220	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Spontaneous antibody , and CD4 and CD8 T-cell responses against XAGE-1b -LRB- GAGED2a -RRB- in non-small cell lung_cancer patients .
17878336	0	CD4	41,44	Zbtb7b	25,31	CD4	Zbtb7b	920	51043	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer .
7642615	0	CD4	73,76	activated_protein-1	50,69	CD4	activated protein-1	920	2353	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	HIV-1 envelope glycoproteins induce activation of activated_protein-1 in CD4 + T cells .
17786278	0	CD4	39,42	alanyl-aminopeptidase	14,35	CD4	alanyl-aminopeptidase	12504(Tax:10090)	16790(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Inhibition of alanyl-aminopeptidase on CD4 + CD25 + regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute_colitis in mice .
11488983	0	CD4	28,31	alpha-melanocyte_stimulating_hormone	72,108	CD4	alpha-melanocyte stimulating hormone	12504(Tax:10090)	18976(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	In vitro induction of CD25 + CD4 + regulatory T cells by the neuropeptide alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- .
19432400	0	CD4	70,73	alpha-synuclein	30,45	CD4	alpha-synuclein	920	6622	Gene	Gene	+|compound|START_ENTITY regulation|nmod|+ regulation|amod|END_ENTITY	Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4 + CD25 + T cells .
18390587	0	CD4	79,82	annexin-1	34,43	CD4	annexin-1	920	301	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid_arthritis CD4 + T cells .
23267026	0	CD4	28,31	annexin_A1	14,24	CD4	annexin A1	12504(Tax:10090)	16952(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Deficiency of annexin_A1 in CD4 + T cells exacerbates T cell-dependent inflammation .
21255222	0	CD4	29,32	aquaporin-4	14,25	CD4	aquaporin-4	12504(Tax:10090)	11829(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Novel role of aquaporin-4 in CD4 + CD25 + T regulatory cell development and severity of Parkinson 's _ disease .
10886394	0	CD4	41,44	aryl_hydrocarbon_receptor	139,164	CD4	aryl hydrocarbon receptor	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	Generation|nmod|START_ENTITY Generation|dep|cells cells|nmod|activation activation|nmod|END_ENTITY	Generation of alphabeta T-cell receptor + CD4 - CD8 + cells in major histocompatibility complex class I-deficient mice upon activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
12490139	0	CD4	146,149	aryl_hydrocarbon_receptor	26,51	CD4	aryl hydrocarbon receptor	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ END_ENTITY|dep|expression	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
16177056	0	CD4	123,126	aryl_hydrocarbon_receptor	32,57	CD4	aryl hydrocarbon receptor	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY population|nmod|cells generates|dobj|population generates|nsubj|activation activation|nmod|END_ENTITY	Cutting edge : activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4 + CD25 + cells with characteristics of regulatory T cells .
18382861	0	CD4	194,197	aryl_hydrocarbon_receptor	165,190	CD4	aryl hydrocarbon receptor	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation of alloreactive CD8 + T cells toward a regulatory T cell phenotype by a mechanism that is dependent on aryl_hydrocarbon_receptor in CD4 + T cells .
20231432	0	CD4	42,45	aryl_hydrocarbon_receptor	74,99	CD4	aryl hydrocarbon receptor	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells drives|dobj|secretion drives|advcl|stimulating stimulating|dobj|END_ENTITY	Notch signaling drives IL-22 secretion in CD4 + T cells by stimulating the aryl_hydrocarbon_receptor .
21525997	0	CD4	57,60	aryl_hydrocarbon_receptor	76,101	CD4	aryl hydrocarbon receptor	920	196	Gene	Gene	T|compound|START_ENTITY favors|nmod|T favors|nsubj|cells cells|nmod|END_ENTITY	In vivo dioxin favors interleukin-22 production by human CD4 + T cells in an aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent manner .
22609446	0	CD4	91,94	aryl_hydrocarbon_receptor	4,29	CD4	aryl hydrocarbon receptor	920	196	Gene	Gene	cells|amod|START_ENTITY ve|dobj|cells monocytes|acl|ve acts|nmod|monocytes ligand|ccomp|acts ligand|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AhR -RRB- ligand VAF347 selectively acts on monocytes and na ve CD4 -LRB- + -RRB- Th cells to promote the development of IL-22-secreting Th cells .
26071552	0	CD4	86,89	aryl_hydrocarbon_receptor	18,43	CD4	aryl hydrocarbon receptor	12504(Tax:10090)	11622(Tax:10090)	Gene	Gene	response|compound|START_ENTITY enhances|dobj|response enhances|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the aryl_hydrocarbon_receptor during development enhances the pulmonary CD4 + T cell response to viral_infection .
21914629	0	CD4	86,89	b2GPI	112,117	CD4	b2GPI	920	350	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Tolerogenic dendritic cells inhibit antiphospholipid_syndrome derived effector/memory CD4 T cell response to b2GPI .
23894198	0	CD4	65,68	beclin-1	27,35	CD4	beclin-1	920	8678	Gene	Gene	responses|nummod|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory_syncytial_virus_infection .
9780421	0	CD4	149,152	beta_2-microglobulin	104,124	CD4	beta 2-microglobulin	920	567	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Discriminative value for AIDS case of erythrocyte sedimentation rate , immunoglobulins IgA and IgM , and beta_2-microglobulin in combination with the CD4 + lymphocyte count -RSB- .
19995950	0	CD4	55,58	c-Rel	0,5	CD4	c-Rel	12504(Tax:10090)	19696(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells required|nmod|development required|nsubjpass|END_ENTITY	c-Rel is required for the development of thymic Foxp3 + CD4 regulatory T cells .
20049877	0	CD4	58,61	c-Rel	0,5	CD4	c-Rel	920	5966	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells crucial|nmod|induction crucial|nsubj|END_ENTITY	c-Rel is crucial for the induction of Foxp3 -LRB- + -RRB- regulatory CD4 -LRB- + -RRB- T cells but not T -LRB- H -RRB- 17 cells .
18602973	0	CD4	152,155	cKrox	64,69	CD4	cKrox	920	51043	Gene	Gene	+|compound|START_ENTITY commitment|nmod|+ controlling|dobj|commitment factors|acl|controlling expression|appos|factors expression|nmod|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
24730590	0	CD4	71,74	cartilage_glycoprotein_39	42,67	CD4	cartilage glycoprotein 39	920	1116	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Antigen-specific over-expression of human cartilage_glycoprotein_39 on CD4 + CD25 + forkhead_box_protein_3 + regulatory T cells in the generation of glucose-6-phosphate_isomerase-induced arthritis .
24162716	0	CD4	89,92	ccr5	65,69	CD4	ccr5	920	1234	Gene	Gene	cells|nummod|START_ENTITY protects|dobj|cells protects|nsubj|END_ENTITY	Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4 + T cells from HIV-1_infection .
11056676	0	CD4	77,80	chemokine_receptor	33,51	CD4	chemokine receptor	920	7852	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cytokine , activation marker , and chemokine_receptor expression by individual CD4 -LRB- + -RRB- memory T cells in rheumatoid_arthritis synovium .
11086103	0	CD4	91,94	chemokine_receptor	34,52	CD4	chemokine receptor	920	7852	Gene	Gene	accumulation|compound|START_ENTITY role|nmod|accumulation play|dobj|role play|nsubj|END_ENTITY	Stromal cell-derived factor-1-CXC chemokine_receptor 4 interactions play a central role in CD4 + T cell accumulation in rheumatoid_arthritis synovium .
12699425	0	CD4	70,73	chemokine_receptor	24,42	CD4	chemokine receptor	920	7852	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	CCR4 is an up-regulated chemokine_receptor of peripheral blood memory CD4 + T cells in Crohn 's _ disease .
15178707	0	CD4	82,85	chemokine_receptor	43,61	CD4	chemokine receptor	920	7852	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Lysophosphatidylcholine up-regulates CXCR4 chemokine_receptor expression in human CD4 T cells .
22471287	0	CD4	73,76	chemokine_receptor	40,58	CD4	chemokine receptor	920	7852	Gene	Gene	subsets|compound|START_ENTITY circulating|nsubj|subsets inhibits|advcl|circulating inhibits|dobj|expression expression|compound|END_ENTITY	Cyclosporin but not everolimus inhibits chemokine_receptor expression on CD4 + T cell subsets circulating in the peripheral blood of renal transplant recipients .
9670042	0	CD4	0,3	chemokine_receptor	163,181	CD4	chemokine receptor	920	7852	Gene	Gene	cell|compound|START_ENTITY cytokine|nsubj|cell cytokine|parataxis|instructs instructs|xcomp|express express|dobj|expression expression|nmod|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
9670042	0	CD4	92,95	chemokine_receptor	163,181	CD4	chemokine receptor	920	7852	Gene	Gene	cells|compound|START_ENTITY instructs|dobj|cells instructs|xcomp|express express|dobj|expression expression|nmod|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
11057864	0	CD4	17,20	coagulation_factor_VIII	33,56	CD4	coagulation factor VIII	920	2157	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	Sensitization of CD4 + T cells to coagulation_factor_VIII : response in congenital and acquired_hemophilia patients and in healthy subjects .
12911593	0	CD4	6,9	coagulation_factor_VIII	57,80	CD4	coagulation factor VIII	920	2157	Gene	Gene	T-cell|compound|START_ENTITY epitope|nsubj|T-cell epitope|nmod|domain domain|nmod|END_ENTITY	Human CD4 + T-cell epitope repertoire on the C2 domain of coagulation_factor_VIII .
15304045	0	CD4	28,31	coagulation_factor_VIII	63,86	CD4	coagulation factor VIII	920	2157	Gene	Gene	repertoire|nmod|START_ENTITY T|nsubj|repertoire T|nmod|domain domain|nmod|END_ENTITY	Epitope repertoire of human CD4 -LRB- + -RRB- T cells on the A3 domain of coagulation_factor_VIII .
17479189	0	CD4	23,26	coagulation_factor_VIII	49,72	CD4	coagulation factor VIII	920	2157	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Cytokine production by CD4 + T cells specific for coagulation_factor_VIII in healthy subjects and haemophilia_A patients .
23933558	0	CD4	42,45	coronin_1	19,28	CD4	coronin 1	920	11151	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Diverging role for coronin_1 in antiviral CD4 + and CD8 + T cell responses .
22273578	0	CD4	59,62	cxcr4	38,43	CD4	cxcr4	12504(Tax:10090)	7852	Gene	Gene	T|compound|START_ENTITY promotes|dobj|T promotes|nsubj|editing editing|nmod|END_ENTITY	Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4 -LRB- + -RRB- T cell resistance and enrichment .
16740732	0	CD4	0,3	cytochrome_B	38,50	CD4	cytochrome B	920	4519	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	CD4 + T-cell response to mitochondrial cytochrome_B in human melanoma .
24269199	0	CD4	57,60	cytotoxic_T-lymphocyte-associated_protein_4	10,53	CD4	cytotoxic T-lymphocyte-associated protein 4	12504(Tax:10090)	12477(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Effect of cytotoxic_T-lymphocyte-associated_protein_4 on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine schistosomiasis japonica .
24028204	0	CD4	50,53	cytotoxic_T-lymphocyte_antigen_4	14,46	CD4	cytotoxic T-lymphocyte antigen 4	920	1493	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Expression of cytotoxic_T-lymphocyte_antigen_4 on CD4 + and CD8 + T cells is increased in acute_lung_injury .
23039885	0	CD4	88,91	cytotoxic_T_lymphocyte_antigen_4	41,73	CD4	cytotoxic T lymphocyte antigen 4	920	1493	Gene	Gene	CD25|compound|START_ENTITY expression|nmod|CD25 expression|amod|END_ENTITY	FOXP3 , CBLB and ITCH gene expression and cytotoxic_T_lymphocyte_antigen_4 expression on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- T cells in multiple_sclerosis .
17530719	0	CD4	53,56	decay-accelerating_factor_1	22,49	CD4	decay-accelerating factor 1	12504(Tax:10090)	13136(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Reduced expression of decay-accelerating_factor_1 on CD4 + T cells in murine systemic_autoimmune_disease .
24086683	0	CD4	49,52	defensin_5	27,37	CD4	defensin 5	920	1670	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Anti-HIV activity of human defensin_5 in primary CD4 + T cells under serum-deprived conditions is a consequence of defensin-mediated cytotoxicity .
8086417	0	CD4	52,55	env	71,74	CD4	env	920	155971(Tax:11676)	Gene	Gene	gp120|nummod|START_ENTITY gp120|amod|binding binding|nmod|glycoprotein glycoprotein|compound|END_ENTITY	Inhibitors of the conformational switch involved in CD4 binding by the env glycoprotein gp120 from human_immunodeficiency_virus_type_1 _ -LRB- HIV1 -RRB- .
9127013	0	CD4	85,88	env	6,9	CD4	env	713807(Tax:9544)	100428948	Gene	Gene	cells|compound|START_ENTITY administered|nmod|cells vaccine|acl|administered END_ENTITY|dobj|vaccine	HIV-1 env DNA vaccine administered to rhesus_monkeys elicits MHC class II-restricted CD4 + T helper cells that secrete IFN-gamma and TNF-alpha .
20702780	0	CD4	34,37	erythropoietin	75,89	CD4	erythropoietin	920	2056	Gene	Gene	specific|compound|START_ENTITY specific|nmod|END_ENTITY	Quantification of the preexisting CD4 T-cell repertoire specific for human erythropoietin reveals its immunogenicity potential .
21619451	0	CD4	73,76	erythropoietin	123,137	CD4	erythropoietin	920	2056	Gene	Gene	lymphocytes|compound|START_ENTITY phosphorylation|nmod|lymphocytes analysis|nmod|phosphorylation treated|nsubj|analysis treated|nmod|END_ENTITY	Flow cytometric analysis of STAT5 phosphorylation and CD95 expression in CD4 + T lymphocytes treated with recombinant human erythropoietin .
23180360	0	CD4	90,93	erythropoietin	35,49	CD4	erythropoietin	920	2056	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	The influence of recombinant human erythropoietin on apoptosis and cytokine production of CD4 + lymphocytes from hemodialyzed patients .
10655504	0	CD4	102,105	focal_adhesion_kinase	63,84	CD4	focal adhesion kinase	920	5747	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	HIV-1 envelope induces activation of caspase-3 and cleavage of focal_adhesion_kinase in primary human CD4 -LRB- + -RRB- T cells .
18505426	0	CD4	39,42	forkhead_box_P3	13,28	CD4	forkhead box P3	920	50943	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Reduction of forkhead_box_P3 levels in CD4 + CD25high T cells in patients with new-onset systemic_lupus_erythematosus .
21791023	0	CD4	14,17	forkhead_box_P3	19,34	CD4	forkhead box P3	920	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nummod|+	Expression of CD4 + forkhead_box_P3 -LRB- FOXP3 -RRB- + regulatory T cells in inflammatory_bowel_disease .
21985361	0	CD4	140,143	forkhead_box_P3	145,160	CD4	forkhead box P3	920	50943	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Chronic_lymphocytic_leukaemia cells drive the global CD4 + T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4 + forkhead_box_P3 + T cells .
23375290	0	CD4	25,28	forkhead_box_p3	42,57	CD4	forkhead box p3	920	50943	Gene	Gene	CD25|compound|START_ENTITY affect|dobj|CD25 affect|dep|T T|nsubj|END_ENTITY	Sirolimus did not affect CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- forkhead_box_p3 -LRB- + -RRB- T cells of peripheral blood in renal transplant recipients .
18282273	0	CD4	5,8	foxp3	14,19	CD4	foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|determine determine|nsubj|cell cell|amod|END_ENTITY	Does CD4 + CD25 + foxp3 + cell -LRB- Treg -RRB- and IL-10 profile determine susceptibility to immune reconstitution inflammatory_syndrome -LRB- IRIS -RRB- in HIV_disease ?
19902068	0	CD4	36,39	foxp3	45,50	CD4	foxp3	920	50943	Gene	Gene	CD25|compound|START_ENTITY markers|nmod|CD25 Expression|nmod|markers +|nsubj|Expression +|dobj|cells cells|amod|END_ENTITY	Expression of markers of regulatory CD4 + CD25 + foxp3 + cells in atherosclerotic_plaques of human coronary arteries .
22194713	0	CD4	112,115	foxp3	14,19	CD4	foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY proportions|nmod|cells altering|dobj|proportions exacerbates|advcl|altering exacerbates|nsubj|Deficiency Deficiency|nmod|cells cells|amod|END_ENTITY	Deficiency of foxp3 regulatory T cells exacerbates autoimmune_arthritis by altering the synovial proportions of CD4 T cells and dendritic cells .
23874581	0	CD4	142,145	foxp3	147,152	CD4	foxp3	12504(Tax:10090)	20371(Tax:10090)	Gene	Gene	ICOS|compound|START_ENTITY ICOS|compound|END_ENTITY	Mesothelin virus-like particle immunization controls pancreatic_cancer growth through CD8 + T cell induction and reduction in the frequency of CD4 + foxp3 + ICOS - regulatory T cells .
17804530	0	CD4	55,58	fractalkine_receptor	22,42	CD4	fractalkine receptor	920	1524	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nmod|END_ENTITY	Surface expression of fractalkine_receptor -LRB- CX3CR1 -RRB- on CD4 + / CD28 T cells in RA patients and correlation with atherosclerotic_damage .
15163734	0	CD4	53,56	gC1qR	44,49	CD4	gC1qR	920	708	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Direct binding of hepatitis_C_virus core to gC1qR on CD4 + and CD8 + T cells leads to impaired activation of Lck and Akt .
19473882	0	CD4	19,22	gC1qR	13,18	CD4	gC1qR	920	708	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	Frequency of gC1qR + CD4 + T cells increases during acute hepatitis_C_virus infection and remains elevated in patients with chronic_infection .
20617170	0	CD4	26,29	gC1qR	17,22	CD4	gC1qR	920	708	Gene	Gene	cells|compound|START_ENTITY engages|nmod|cells engages|dobj|END_ENTITY	HIV gp41 engages gC1qR on CD4 + T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway .
10064617	0	CD4	104,107	gp120	34,39	CD4	gp120	920	3700	Gene	Gene	binds|nmod|START_ENTITY peptide|acl:relcl|binds chemokine|nsubj|peptide chemokine|nsubj|domain-derived domain-derived|compound|END_ENTITY	A functional , discontinuous HIV-1 gp120 C3/C4 domain-derived , branched , synthetic peptide that binds to CD4 and inhibits MIP-1alpha chemokine binding .
10229873	0	CD4	33,36	gp120	18,23	CD4	gp120	920	3700	Gene	Gene	chemotaxis|compound|START_ENTITY mediates|dobj|chemotaxis mediates|nsubj|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10229873	0	CD4	90,93	gp120	18,23	CD4	gp120	920	3700	Gene	Gene	CXCR4|nmod|START_ENTITY mediates|nmod|CXCR4 mediates|nsubj|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10356363	0	CD4	41,44	gp120	66,71	CD4	gp120	920	3700	Gene	Gene	express|dobj|START_ENTITY express|nmod|protein protein|amod|END_ENTITY	Human glomerular epithelial cell express CD4 and interaction with gp120 protein promotes PYK2 tyrosine phosphorylation .
10358157	0	CD4	114,117	gp120	105,110	CD4	gp120	12504(Tax:10090)	155971(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY chemokine|nmod|cells chemokine|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4 + T cells .
10413516	0	CD4	86,89	gp120	26,31	CD4	gp120	920	3700	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|changes changes|nmod|END_ENTITY	Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic .
10438529	0	CD4	9,12	gp120	73,78	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|glycoproteins glycoproteins|amod|END_ENTITY	Roles of CD4 and coreceptors in binding , endocytosis , and proteolysis of gp120 envelope glycoproteins derived from human_immunodeficiency_virus_type_1 .
10555208	0	CD4	135,138	gp120	59,64	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	presence|nmod|START_ENTITY CXC-R4|nmod|presence binds|advcl|CXC-R4 binds|nsubj|END_ENTITY	In a human lymphomyeloid progenitor cell line -LRB- KG-1 -RRB- HIV-1 gp120 binds to chemokine-receptors CXC-R4 and CCR5 , only in the presence of CD4 .
10775592	0	CD4	118,121	gp120	95,100	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	blocking|nmod|START_ENTITY blocking|nmod|interaction interaction|amod|END_ENTITY	Multiple antiviral activities of cyanovirin-N : blocking of human_immunodeficiency_virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses .
10779509	0	CD4	36,39	gp120	70,75	CD4	gp120	920	3700	Gene	Gene	molecules|compound|START_ENTITY function|nmod|molecules function|nmod|END_ENTITY	Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human_immunodeficiency_virus .
10899322	0	CD4	96,99	gp120	10,15	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	modulated|nmod|START_ENTITY mechanism|acl|modulated CD26|nmod|mechanism adenosine_deaminase|nmod|CD26 expression|amod|adenosine_deaminase the|nmod|expression inhibits|dobj|the inhibits|nsubj|END_ENTITY	The HIV-1 gp120 inhibits the binding of adenosine_deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression .
10941932	0	CD4	44,47	gp120	74,79	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	co-down-modulation|nmod|START_ENTITY level|nmod|co-down-modulation primed|nsubj|level primed|nmod|END_ENTITY	Differential level in co-down-modulation of CD4 and CXCR4 primed by HIV-1 gp120 in response to phorbol_ester , PMA , among HIV-1 isolates .
11192301	0	CD4	95,98	gp120	70,75	CD4	gp120	920	3700	Gene	Gene	binding|nmod|START_ENTITY receptors|amod|binding END_ENTITY|nmod|receptors	Short synthetic peptides derived from viral proteins compete with HIV gp120 for the binding to CD4 receptors .
11290759	0	CD4	94,97	gp120	48,53	CD4	gp120	920	3700	Gene	Gene	loss|nmod|START_ENTITY induced|dobj|loss induced|nsubj|mechanism mechanism|nmod|END_ENTITY	A CCR5-dependent novel mechanism for type 1 HIV gp120 induced loss of macrophage cell surface CD4 .
11305358	0	CD4	13,16	gp120	87,92	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Use|nmod|START_ENTITY transgenic_mice|nsubj|Use transgenic_mice|advcl|studying studying|dobj|immunogenicity immunogenicity|nmod|END_ENTITY	Use of human CD4 transgenic_mice for studying immunogenicity of HIV-1 envelope protein gp120 .
11327825	0	CD4	120,123	gp120	109,114	CD4	gp120	920	3700	Gene	Gene	weakens|nmod|START_ENTITY weakens|dobj|kinetics kinetics|nmod|interaction interaction|nmod|END_ENTITY	Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with CD4 .
11356967	0	CD4	31,34	gp120	87,92	CD4	gp120	920	3700	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Antigenic variation within the CD4 binding site of human_immunodeficiency_virus_type_1 gp120 : effects on chemokine receptor utilization .
11409875	0	CD4	27,30	gp120	78,83	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	cell|compound|START_ENTITY Dys-regulation|nmod|cell function|nsubj|Dys-regulation function|nmod|domain domain|nmod|END_ENTITY	Dys-regulation of effector CD4 + T cell function by the V3 domain of the HIV-1 gp120 during antigen presentation .
11602735	0	CD4	115,118	gp120	137,142	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11602735	0	CD4	115,118	gp120	50,55	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY specific|nmod|domain antibodies|amod|specific T|nmod|antibodies T|nsubj|Inhibition Inhibition|nmod|presentation presentation|amod|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11602735	0	CD4	72,75	gp120	137,142	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	presentation|nmod|START_ENTITY Inhibition|nmod|presentation T|nsubj|Inhibition T|nmod|antibodies antibodies|amod|specific specific|nmod|domain domain|nmod|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11602735	0	CD4	72,75	gp120	50,55	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	presentation|nmod|START_ENTITY presentation|amod|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11777947	0	CD4	7,10	gp120	84,89	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	responses|compound|START_ENTITY elicited|nsubj|responses elicited|xcomp|expressing expressing|dobj|END_ENTITY	Potent CD4 + T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF .
12097605	0	CD4	129,132	gp120	84,89	CD4	gp120	920	3700	Gene	Gene	ability|nmod|START_ENTITY accompanied|nmod|ability accompanied|nmod|selection selection|nmod|variants variants|amod|END_ENTITY	Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4 .
12477867	0	CD4	99,102	gp120	155,160	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human_immunodeficiency_virus_type_1 gp120 .
12477875	0	CD4	0,3	gp120	65,70	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	antibodies|nummod|START_ENTITY inhibit|nsubj|antibodies inhibit|dobj|interaction interaction|nummod|END_ENTITY	CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5 .
12584309	0	CD4	146,149	gp120	135,140	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	based|nmod|START_ENTITY based|nmod|interaction interaction|nmod|END_ENTITY	Neutralization of human_immunodeficiency_virus_type_1 by sCD4-17b , a single-chain chimeric protein , based on sequential interaction of gp120 with CD4 and coreceptor .
1279195	0	CD4	104,107	gp120	56,61	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	site|compound|START_ENTITY component|nmod|site loop|nmod|component loop|amod|END_ENTITY	Relationship of the human_immunodeficiency_virus_type_1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region .
1352879	0	CD4	26,29	gp120	113,118	CD4	gp120	920	3700	Gene	Gene	mimetic|compound|START_ENTITY Design|nmod|mimetic Design|acl:relcl|inhibits inhibits|dobj|END_ENTITY	Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes .
1353060	0	CD4	58,61	gp120	109,114	CD4	gp120	920	3700	Gene	Gene	cells|nummod|START_ENTITY Analysis|nmod|cells Analysis|dep|END_ENTITY	Analysis of the basis of resistance and susceptibility of CD4 + T cells to human immunodeficiency virus -LRB- HIV -RRB- - gp120 induced anergy .
1356673	0	CD4	103,106	gp120	83,88	CD4	gp120	920	3700	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Human_immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro : a possible mechanism of T lymphocyte depletion in vivo .
14498981	0	CD4	28,31	gp120	89,94	CD4	gp120	920	3700	Gene	Gene	variations|nmod|START_ENTITY induced|nsubj|variations induced|dobj|sites sites|nmod|CCR5-tropic CCR5-tropic|appos|variants variants|amod|END_ENTITY	Antigenic variations in the CD4 induced sites of the CCR5-tropic , pathogenic SHIVsf162p3 gp120 variants .
14585210	0	CD4	15,18	gp120	61,66	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Propagation of CD4 + T cells specific for HIV_type_1 envelope gp120 from chronically HIV_type_1-infected subjects .
1465431	0	CD4	57,60	gp120	29,34	CD4	gp120	920	3700	Gene	Gene	domain|compound|START_ENTITY ridge|nmod|domain ridge|compound|END_ENTITY	Human_immunodeficiency virus gp120 binding C ` C '' ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules .
14691297	0	CD4	104,107	gp120	89,94	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	coreceptors|compound|START_ENTITY role|nmod|coreceptors Induction|dep|role Induction|nmod|cells cells|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Induction of intercellular_adhesion_molecule-1 on human brain endothelial cells by HIV-1 gp120 : role of CD4 and chemokine coreceptors .
1493053	0	CD4	138,141	gp120	147,152	CD4	gp120	920	3700	Gene	Gene	interaction|nmod|START_ENTITY induced|nmod|interaction induced|nmod|END_ENTITY	Changes in the reactivity and neutralizing activity of a type-specific neutralizing monoclonal antibody induced by interaction of soluble CD4 with gp120 .
1500858	0	CD4	55,58	gp120	33,38	CD4	gp120	920	3700	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	The human immunodeficiency virus gp120 binding site on CD4 : delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure .
15103622	0	CD4	24,27	gp120	76,81	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	insight|nmod|START_ENTITY binding-induced|nsubj|insight binding-induced|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Atomic insight into the CD4 binding-induced conformational changes in HIV-1 gp120 .
15327894	0	CD4	49,52	gp120	20,25	CD4	gp120	920	3700	Gene	Gene	independence|nummod|START_ENTITY contribute|nmod|independence contribute|nsubj|Determinants Determinants|nmod|END_ENTITY	Determinants within gp120 and gp41 contribute to CD4 independence of SIV Envs .
1533631	0	CD4	113,116	gp120	96,101	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	screen|nmod|START_ENTITY screen|nmod|analysis analysis|nmod|interaction interaction|nmod|HIV-1 HIV-1|nummod|END_ENTITY	An efficient phage plaque screen for the random mutational analysis of the interaction of HIV-1 gp120 with human CD4 .
1535086	0	CD4	89,92	gp120	36,41	CD4	gp120	920	3700	Gene	Gene	membrane|nummod|START_ENTITY down-modulation|nmod|membrane associated|nmod|down-modulation associated|nsubjpass|Internalization Internalization|nmod|END_ENTITY	Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment_of_T cell activation .
1537336	0	CD4	45,48	gp120	116,121	CD4	gp120	920	3700	Gene	Gene	protein|compound|START_ENTITY kills|nsubj|protein kills|dobj|cells cells|acl:relcl|express express|dobj|END_ENTITY	A recombinant diphtheria toxin related human CD4 fusion protein specifically kills HIV_infected cells which express gp120 but selects fusion toxin resistant cells which carry HIV .
15890908	0	CD4	17,20	gp120	76,81	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|amod|Interaction	Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human_immunodeficiency_virus_type_1 isolate .
15893666	0	CD4	25,28	gp120	74,79	CD4	gp120	920	3700	Gene	Gene	mimics|nmod|START_ENTITY mimics|nmod|structures structures|amod|END_ENTITY	Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures , molecular mimicry , and neutralization breadth .
15946678	0	CD4	0,3	gp120	50,55	CD4	gp120	920	3700	Gene	Gene	binding|compound|START_ENTITY locks|nsubj|binding locks|nmod|END_ENTITY	CD4 binding partially locks the bridging sheet in gp120 but leaves the beta2/3 strands flexible .
1614536	0	CD4	40,43	gp120	19,24	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors .
16189008	0	CD4	127,130	gp120	158,163	CD4	gp120	920	3700	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Structure of the Fab fragment of F105 , a broadly reactive anti-human immunodeficiency virus -LRB- HIV -RRB- antibody that recognizes the CD4 binding site of HIV_type_1 gp120 .
16260021	0	CD4	58,61	gp120	6,11	CD4	gp120	920	3700	Gene	Gene	T-cells|compound|START_ENTITY translocation|nmod|T-cells induces|dobj|translocation induces|nsubj|END_ENTITY	HIV-1 gp120 induces NFAT nuclear translocation in resting CD4 + T-cells .
16331979	0	CD4	58,61	gp120	28,33	CD4	gp120	920	3700	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Protein minimization of the gp120 binding region of human CD4 .
1656094	0	CD4	110,113	gp120	59,64	CD4	gp120	920	3700	Gene	Gene	clones|compound|START_ENTITY induce|nmod|clones induce|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4 + T-cell clones .
1696717	0	CD4	11,14	gp120	100,105	CD4	gp120	920	3700	Gene	Gene	cells|compound|START_ENTITY cells|nmod|regions regions|nmod|END_ENTITY	Priming of CD4 + T cells specific for conserved regions of human_immunodeficiency_virus glycoprotein gp120 in humans immunized with a recombinant envelope_protein .
1698804	0	CD4	79,82	gp120	23,28	CD4	gp120	920	3700	Gene	Gene	assessment|nmod|START_ENTITY binding|nsubj|assessment protein|parataxis|binding protein|dobj|expression expression|amod|END_ENTITY	HIV-1 envelope protein gp120 expression by secretion in E. _ coli : assessment of CD4 binding and use in epitope mapping .
1698964	0	CD4	24,27	gp120	36,41	CD4	gp120	920	3700	Gene	Gene	bind|compound|START_ENTITY bearing|dobj|bind bearing|nmod|END_ENTITY	Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120 .
1698964	0	CD4	24,27	gp120	93,98	CD4	gp120	920	3700	Gene	Gene	bind|compound|START_ENTITY bearing|dobj|bind cells|acl|bearing covered|nsubj|cells covered|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120 .
1706342	0	CD4	24,27	gp120	54,59	CD4	gp120	920	3700	Gene	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV_infection and virus-mediated fusion .
1711118	0	CD4	78,81	gp120	69,74	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Phosphorothioate oligodeoxycytidine interferes with binding of HIV-1 gp120 to CD4 .
17131136	0	CD4	99,102	gp120	52,57	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	binding|compound|START_ENTITY induced|nmod|binding changes|acl|induced geometrical|nmod|changes geometrical|dobj|properties properties|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Dynamic domains and geometrical properties of HIV-1 gp120 during conformational changes induced by CD4 binding .
1713692	0	CD4	39,42	gp120	137,142	CD4	gp120	920	3700	Gene	Gene	domain|compound|START_ENTITY strand|nmod|domain Mutations|nmod|strand affect|nsubj|Mutations affect|ccomp|antigens antigens|nsubj|interactions interactions|nmod|END_ENTITY	Mutations in the D strand of the human CD4 V1 domain affect CD4 interactions with the human_immunodeficiency_virus envelope glycoprotein gp120 and HLA class II antigens similarly .
1713692	0	CD4	60,63	gp120	137,142	CD4	gp120	920	3700	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	Mutations in the D strand of the human CD4 V1 domain affect CD4 interactions with the human_immunodeficiency_virus envelope glycoprotein gp120 and HLA class II antigens similarly .
17180012	0	CD4	4,7	gp120	38,43	CD4	gp120	920	3700	Gene	Gene	identities|compound|START_ENTITY identities|nmod|END_ENTITY	Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis ?
1720631	0	CD4	63,66	gp120	37,42	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	binding|compound|START_ENTITY involved|nmod|binding involved|nsubjpass|105-117 105-117|nmod|HIV-1 HIV-1|nummod|END_ENTITY	N-terminal residues 105-117 of HIV-1 gp120 are not involved in CD4 binding .
1727487	0	CD4	85,88	gp120	151,156	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	resistant|nmod|START_ENTITY neutralization|amod|resistant differ|nsubj|neutralization differ|nmod|retention retention|amod|END_ENTITY	Virions of primary human_immunodeficiency_virus_type_1 isolates resistant to soluble CD4 -LRB- sCD4 -RRB- neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates .
1730924	0	CD4	84,87	gp120	71,76	CD4	gp120	24932(Tax:10116)	155971(Tax:11676)	Gene	Gene	Construction|nmod|START_ENTITY Construction|nmod|site site|nmod|END_ENTITY	Construction of a binding site for human_immunodeficiency_virus_type_1 gp120 in rat CD4 .
1732513	0	CD4	58,61	gp120	71,76	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	region|nmod|START_ENTITY charged|nmod|region charged|nmod|binding binding|compound|END_ENTITY	Contribution of charged amino_acids in the CDR2 region of CD4 to HIV-1 gp120 binding .
1736526	0	CD4	72,75	gp120	100,105	CD4	gp120	920	3700	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Human_immunodeficiency_virus_type_2 envelope glycoprotein : differential CD4 interactions of soluble gp120 versus the assembled envelope complex .
1738091	0	CD4	122,125	gp120	100,105	CD4	gp120	920	3700	Gene	Gene	binding|compound|START_ENTITY type|nmod|binding type|dobj|glycoprotein glycoprotein|amod|END_ENTITY	Contribution of disulfide bonds in the carboxyl terminus of the human immunodeficiency virus type I gp120 glycoprotein to CD4 binding .
1741386	0	CD4	99,102	gp120	169,174	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	neutralization|nmod|START_ENTITY human_immunodeficiency_virus_type_1|nmod|neutralization isolates|nmod|human_immunodeficiency_virus_type_1 Resistance|nmod|isolates due|nsubj|Resistance due|xcomp|lower lower|nmod|END_ENTITY	Resistance of primary isolates of human_immunodeficiency_virus_type_1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120 .
18322210	0	CD4	133,136	gp120	79,84	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	cell|compound|START_ENTITY recognition|nmod|cell critical|nmod|recognition glycosylation|acl:relcl|critical glycosylation|nmod|region region|nmod|END_ENTITY	Identification of an N-linked glycosylation in the C4 region of HIV-1 envelope gp120 that is critical for recognition of neighboring CD4 T cell epitopes .
18638381	0	CD4	74,77	gp120	44,49	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	response|compound|START_ENTITY suppress|dobj|response suppress|nsubj|Antibodies Antibodies|nmod|site site|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response .
1870202	0	CD4	102,105	gp120	83,88	CD4	gp120	24932(Tax:10116)	155971(Tax:11676)	Gene	Gene	affinity|nmod|START_ENTITY affinity|amod|END_ENTITY	Recombinant CD4-selected human_immunodeficiency_virus_type_1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity .
1888898	0	CD4	19,22	gp120	34,39	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|HIV-1 HIV-1|nummod|END_ENTITY	The interaction of CD4 with HIV-1 gp120 .
1896455	0	CD4	136,139	gp120	28,33	CD4	gp120	450124(Tax:9598)	155971(Tax:11676)	Gene	Gene	human_immunodeficiency_virus_type_1|nmod|START_ENTITY complex|nmod|human_immunodeficiency_virus_type_1 dissociation|nmod|complex dissociation|amod|END_ENTITY	Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human_immunodeficiency_virus_type_1 by soluble CD4 and CD4 peptide derivatives : implications for the role of the complementarity-determining region 3-like region in membrane fusion .
19000821	0	CD4	15,18	gp120	75,80	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	mimics|nsubj|START_ENTITY mimics|nmod|pocket pocket|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120 .
19297493	0	CD4	59,62	gp120	36,41	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	migration|compound|START_ENTITY reprogramming|nmod|migration reprogramming|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 gp120 reprogramming of CD4 + T-cell migration provides a mechanism for lymphadenopathy .
19572053	0	CD4	0,3	gp120	25,30	CD4	gp120	920	3700	Gene	Gene	Treated|compound|START_ENTITY Treated|nmod|END_ENTITY	CD4 T Cells Treated with gp120 Acquire a CD45R0 + / CD45RA + Phenotype .
1978941	0	CD4	71,74	gp120	155,160	CD4	gp120	920	3700	Gene	Gene	region|nmod|START_ENTITY residues|nmod|region analysis|nmod|residues involved|nsubj|analysis involved|nmod|END_ENTITY	Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules .
19965434	0	CD4	50,53	gp120	74,79	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	attachment|compound|START_ENTITY attachment|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120 .
2006155	0	CD4	19,22	gp120	131,136	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	proteins|compound|START_ENTITY Binding|nmod|proteins induces|nsubj|Binding induces|dobj|release release|nmod|END_ENTITY	Binding of soluble CD4 proteins to human_immunodeficiency_virus_type_1 and infected cells induces release of envelope glycoprotein gp120 .
20089638	0	CD4	47,50	gp120	20,25	CD4	gp120	920	3700	Gene	Gene	binding|compound|START_ENTITY disrupted|nmod|binding element|acl|disrupted element|amod|END_ENTITY	A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer .
2018763	0	CD4	23,26	gp120	116,121	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Deamidation|nmod|START_ENTITY Deamidation|nmod|capacity capacity|nmod|END_ENTITY	Deamidation of soluble CD4 at asparagine-52 results in reduced binding capacity for the HIV-1 envelope glycoprotein gp120 .
20357769	0	CD4	44,47	gp120	29,34	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	antibody|compound|START_ENTITY bound|nmod|antibody END_ENTITY|acl|bound	Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity .
2040625	0	CD4	120,123	gp120	39,44	CD4	gp120	920	3700	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|nsubj|Effect Effect|nmod|glycoprotein glycoprotein|amod|END_ENTITY	Effect of human_immunodeficiency_virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes .
2040664	0	CD4	21,24	gp120	141,146	CD4	gp120	920	3700	Gene	Gene	diffusion|nmod|START_ENTITY probed|nsubj|diffusion probed|nmod|derivative derivative|nmod|glycoprotein glycoprotein|appos|END_ENTITY	Lateral diffusion of CD4 on the surface of a human neoplastic T-cell line probed with a fluorescent derivative of the envelope glycoprotein -LRB- gp120 -RRB- of human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- .
20558728	0	CD4	86,89	gp120	56,61	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	binds|nmod|START_ENTITY immunogen|acl:relcl|binds immunogen|amod|END_ENTITY	Design of a non-glycosylated outer_domain-derived HIV-1 gp120 immunogen that binds to CD4 and induces neutralizing antibodies .
20610714	0	CD4	41,44	gp120	6,11	CD4	gp120	920	3700	Gene	Gene	shift|compound|START_ENTITY proximal|nmod|shift glycans|amod|proximal determinants|dobj|glycans determinants|nsubj|END_ENTITY	HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12 .
20619663	0	CD4	138,141	gp120	142,147	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	START_ENTITY|dep|paradigm paradigm|amod|END_ENTITY	Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule : the HIV-1 CD4 : gp120 paradigm .
2062847	0	CD4	0,3	gp120	83,88	CD4	gp120	920	3700	Gene	Gene	conjugates|nummod|START_ENTITY bind|nsubj|conjugates bind|nmod|END_ENTITY	CD4 peptide-protein conjugates , but not recombinant human CD4 , bind to recombinant gp120 from the human_immunodeficiency_virus in the presence of serum from AIDS patients .
2115689	0	CD4	50,53	gp120	89,94	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	HIV-1_infection|nmod|START_ENTITY Prevention|nmod|HIV-1_infection function|nsubj|Prevention function|nmod|END_ENTITY	Prevention of HIV-1_infection and preservation of CD4 function by the binding of CPFs to gp120 .
21635737	0	CD4	34,37	gp120	62,67	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	cavity|compound|START_ENTITY cavity|nmod|END_ENTITY	Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues .
21850260	0	CD4	38,41	gp120	13,18	CD4	gp120	920	3700	Gene	Gene	T-lymphocytes|compound|START_ENTITY activates|nmod|T-lymphocytes activates|nsubj|END_ENTITY	HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin -LRB- LtxA -RRB- .
22117536	0	CD4	74,77	gp120	17,22	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	glycoprotein|compound|START_ENTITY modified|nmod|glycoprotein modified|csubj|Binding Binding|nmod|glycoprotein glycoprotein|amod|END_ENTITY	Binding of HIV-1 gp120 glycoprotein to silica nanoparticles modified with CD4 glycoprotein and CD4 peptide fragments .
22312332	0	CD4	115,118	gp120	99,104	CD4	gp120	12504(Tax:10090)	155971(Tax:11676)	Gene	Gene	Peptides|compound|START_ENTITY END_ENTITY|nmod|Peptides	Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction : Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides .
22345481	0	CD4	22,25	gp120	16,21	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	PGV04 , an HIV-1 gp120 CD4 binding site antibody , is broad and potent in neutralization but does not induce conformational changes characteristic of CD4 .
2251501	0	CD4	60,63	gp120	16,21	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Dissociation Dissociation|nmod|END_ENTITY	Dissociation of gp120 from HIV-1_virions induced by soluble CD4 .
22551420	0	CD4	71,74	gp120	65,70	CD4	gp120	920	3700	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency .
22906742	0	CD4	108,111	gp120	47,52	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	antibodies|compound|START_ENTITY enhanced|nmod|antibodies showed|dobj|enhanced showed|nsubj|proteins proteins|nmod|END_ENTITY	Fusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies .
22954308	0	CD4	59,62	gp120	4,9	CD4	gp120	920	3700	Gene	Gene	cells|compound|START_ENTITY resting|dobj|cells blood|acl|resting chemoattractant|nmod|blood chemoattractant|nsubj|END_ENTITY	HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cells .
2304000	0	CD4	11,14	gp120	95,100	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	binding|compound|START_ENTITY Effects|nmod|binding Effects|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Effects on CD4 binding of anti-peptide sera to the fourth and fifth conserved domains of HIV-1 gp120 .
23077246	0	CD4	98,101	gp120	79,84	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	engages|dobj|START_ENTITY engages|nsubj|alterations alterations|nmod|END_ENTITY	Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5 .
23135713	0	CD4	45,48	gp120	100,105	CD4	gp120	920	3700	Gene	Gene	mutation|compound|START_ENTITY conferred|nmod|mutation conferred|nmod|END_ENTITY	HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120 .
2315327	0	CD4	91,94	gp120	58,63	CD4	gp120	920	3700	Gene	Gene	lymphocytes|compound|START_ENTITY defects|nmod|lymphocytes produces|dobj|defects produces|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 produces immune defects in CD4 + T lymphocytes by inhibiting interleukin_2 mRNA .
23297802	0	CD4	57,60	gp120	29,34	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	binding|nsubj|START_ENTITY reduce|xcomp|binding reduce|advmod|that that|nmod:npmod|mutations mutations|nummod|END_ENTITY	Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity .
2339113	0	CD4	123,126	gp120	80,85	CD4	gp120	920	3700	Gene	Gene	sites|nmod|START_ENTITY contains|dobj|sites contains|nsubj|region region|nmod|END_ENTITY	The N-terminal region of the human immunodeficiency virus envelope glycoprotein gp120 contains potential binding sites for CD4 .
23658524	0	CD4	62,65	gp120	103,108	CD4	gp120	920	3700	Gene	Gene	binding|compound|START_ENTITY binding|nmod|recognition recognition|nmod|base base|amod|END_ENTITY	Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans .
23991039	0	CD4	24,27	gp120	44,49	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1 .
24516533	0	CD4	46,49	gp120	97,102	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY receptors|nmod|cells turnover|nmod|receptors causes|nsubj|turnover causes|dobj|retention retention|nmod|complexes complexes|amod|END_ENTITY	Slow turnover of HIV-1 receptors on quiescent CD4 + T cells causes prolonged surface retention of gp120 immune complexes in vivo .
24550395	0	CD4	138,141	gp120	97,102	CD4	gp120	920	3700	Gene	Gene	dimerization|compound|START_ENTITY impairs|dobj|dimerization glycoprotein|acl:relcl|impairs glycoprotein|appos|END_ENTITY	Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 -LRB- gp120 -RRB- , which impairs thioredoxin-driven CD4 dimerization .
24550395	0	CD4	23,26	gp120	97,102	CD4	gp120	920	3700	Gene	Gene	1|nummod|START_ENTITY reduction|nmod|1 essential|nsubj|reduction essential|nmod|glycoprotein glycoprotein|appos|END_ENTITY	Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 -LRB- gp120 -RRB- , which impairs thioredoxin-driven CD4 dimerization .
24758333	0	CD4	227,230	gp120	130,135	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	site|compound|START_ENTITY Impact|nmod|site Impact|nmod|END_ENTITY	Impact of amino_acid substitutions in the V2 and C2 regions of human_immunodeficiency_virus_type_1 CRF01_AE envelope_glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site .
2537355	1	CD4	67,70	gp120	94,99	CD4	gp120	920	3700	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|presentation presentation|nmod|END_ENTITY	Role of monocyte CD4 in the presentation of gp120 .
2543930	0	CD4	24,27	gp120	73,78	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	residues|compound|START_ENTITY Identification|nmod|residues Identification|acl|affecting affecting|xcomp|binding binding|nsubj|MHC MHC|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding .
2545782	0	CD4	42,45	gp120	96,101	CD4	gp120	920	3700	Gene	Gene	molecules|nummod|START_ENTITY interact|nmod|molecules sulfate|dobj|interact sulfate|advcl|inhibit inhibit|dobj|protein protein|appos|END_ENTITY	Dextran sulfate and heparin interact with CD4 molecules to inhibit the binding of coat protein -LRB- gp120 -RRB- of HIV .
25472996	0	CD4	46,49	gp120	25,30	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	CD4|compound|START_ENTITY Binding|nmod|CD4 Binding|compound|END_ENTITY	The Orientation of HIV-1 gp120 Binding to the CD4 Receptor Differentially Modulates CD4 + T Cell Activation .
25472996	0	CD4	84,87	gp120	25,30	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	The Orientation of HIV-1 gp120 Binding to the CD4 Receptor Differentially Modulates CD4 + T Cell Activation .
2561054	0	CD4	106,109	gp120	67,72	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	recognition|compound|START_ENTITY interactions|nmod|recognition interactions|nmod|END_ENTITY	Oligosaccharide-mediated interactions of the envelope glycoprotein gp120 of HIV-1 that are independent of CD4 recognition .
25639621	0	CD4	91,94	gp120	111,116	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Site|compound|START_ENTITY Enhancement|nmod|Site Enhancement|nmod|END_ENTITY	Enhancement and Induction of HIV-1 Infection through an Assembled Peptide Derived from the CD4 Binding Site of gp120 .
25915507	0	CD4	91,94	gp120	74,79	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Receptor|compound|START_ENTITY Binding|nmod|Receptor Binding|compound|END_ENTITY	HbAHP-25 , an In-Silico Designed Peptide , Inhibits HIV-1 Entry by Blocking gp120 Binding to CD4 Receptor .
25915507	0	CD4	91,94	gp120	74,79	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Receptor|compound|START_ENTITY Binding|nmod|Receptor Binding|compound|END_ENTITY	HbAHP-25 , an In-Silico Designed Peptide , Inhibits HIV-1 Entry by Blocking gp120 Binding to CD4 Receptor .
26671829	0	CD4	37,40	gp120	57,62	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Study of antibody repertoires to the CD4 binding site of gp120 of a Chinese_HIV-1-infected_elite_neutralizer , using 454 sequencing and single-cell sorting .
2845130	0	CD4	95,98	gp120	78,83	CD4	gp120	920	3700	Gene	Gene	prevent|nmod|START_ENTITY prevent|dobj|END_ENTITY	Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4 .
3037522	0	CD4	67,70	gp120	51,56	CD4	gp120	920	3700	Gene	Gene	determinants|nummod|START_ENTITY bound|nmod|determinants glycoprotein|dep|bound glycoprotein|appos|END_ENTITY	Human T-cell lymphotropic virus IIIB glycoprotein -LRB- gp120 -RRB- bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack .
3261864	0	CD4	110,113	gp120	59,64	CD4	gp120	920	3700	Gene	Gene	T4|appos|START_ENTITY region|nmod|T4 located|nmod|region located|nsubjpass|site site|nmod|END_ENTITY	Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 -LRB- CD4 -RRB- and requires the intact variable-region-like domain .
7506554	0	CD4	38,41	gp120	172,177	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	molecule|compound|START_ENTITY properties|nmod|molecule properties|dep|enhancement enhancement|nmod|activation activation|nmod|human_immunodeficiency_virus_type_1 human_immunodeficiency_virus_type_1|nmod|END_ENTITY	Costimulatory properties of the human CD4 molecule : enhancement of CD3-induced T cell activation by human_immunodeficiency_virus_type_1 through viral envelope glycoprotein gp120 .
7518527	0	CD4	76,79	gp120	96,101	CD4	gp120	920	3700	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human_immunodeficiency_virus_type_1 .
7522245	0	CD4	18,21	gp120	0,5	CD4	gp120	920	3700	Gene	Gene	ligation|nmod|START_ENTITY ligation|amod|END_ENTITY	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation .
7523525	0	CD4	76,79	gp120	113,118	CD4	gp120	920	3700	Gene	Gene	site|compound|START_ENTITY site|nmod|molecule molecule|amod|END_ENTITY	Enzyme immunoassay -LRB- ELISA -RRB- for the evaluation of antibodies directed to the CD4 receptor-binding site of the HIV gp120 molecule .
7539755	0	CD4	14,17	gp120	89,94	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	interaction|nummod|START_ENTITY Modulation|nmod|interaction induced|nsubj|Modulation induced|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120 .
7540488	0	CD4	6,9	gp120	94,99	CD4	gp120	920	3700	Gene	Gene	cells|compound|START_ENTITY discriminate|nsubj|cells discriminate|dobj|context context|nmod|epitopes epitopes|nmod|END_ENTITY	Human CD4 + T cells can discriminate the molecular and structural context of T epitopes of HIV gp120 and HIV p66 .
7545243	0	CD4	50,53	gp120	90,95	CD4	gp120	920	3700	Gene	Gene	receptors|compound|START_ENTITY modulation|nmod|receptors requires|nsubj|modulation requires|dobj|prior prior|nmod|END_ENTITY	Phorbol_ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules .
7604010	0	CD4	19,22	gp120	166,171	CD4	gp120	920	3700	Gene	Gene	Oligomerization|nmod|START_ENTITY required|nsubjpass|Oligomerization required|nmod|END_ENTITY	Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120 .
7642208	0	CD4	103,106	gp120	75,80	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	recognition|compound|START_ENTITY effect|nmod|recognition effect|nmod|HIV-1 HIV-1|nummod|END_ENTITY	The effect of a single amino_acid substitution within the V3 loop of HIV-1 gp120 on HLA-DR1-restricted CD4 T-cell recognition .
7680610	0	CD4	105,108	gp120	29,34	CD4	gp120	920	3700	Gene	Gene	lymphocytes|compound|START_ENTITY p56lck|nmod|lymphocytes activate|dobj|p56lck activate|nsubj|END_ENTITY	Human_immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes .
7686944	0	CD4	92,95	gp120	99,104	CD4	gp120	920	3700	Gene	Gene	attachment|nmod|START_ENTITY affected|nmod|attachment affected|nmod|END_ENTITY	Identification of a new neutralizing epitope conformationally affected by the attachment of CD4 to gp120 .
7688820	0	CD4	108,111	gp120	193,198	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	antibodies|nummod|START_ENTITY mutant|nmod|antibodies escape|acl|mutant Resistance|nmod|escape conferred|nsubjpass|Resistance conferred|nmod|change change|nmod|END_ENTITY	Resistance of a human serum-selected human_immunodeficiency_virus_type_1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino_acid change in gp120 .
7811011	0	CD4	180,183	gp120	166,171	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	receptor|compound|START_ENTITY inhibit|nmod|receptor inhibit|xcomp|binding binding|nmod|glycoprotein glycoprotein|appos|END_ENTITY	Assays to detect and characterize human_immunodeficiency_virus_type_1 -LRB- HIV-1 -RRB- receptor antagonists , compounds that inhibit binding of the HIV-1 surface glycoprotein , gp120 , to the CD4 receptor on human T lymphocytes .
7831801	0	CD4	168,171	gp120	83,88	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	interaction|nmod|START_ENTITY inhibit|nmod|interaction inhibit|nsubj|constructs constructs|acl|derived derived|nmod|loop loop|nmod|END_ENTITY	Multibranched peptide constructs derived from the V3 loop of envelope glycoprotein gp120 inhibit human_immunodeficiency_virus_type_1_infection through interaction with CD4 .
7876916	0	CD4	86,89	gp120	55,60	CD4	gp120	920	3700	Gene	Gene	receptor|compound|START_ENTITY binding|nmod|receptor binding|nsubj|END_ENTITY	Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor .
7902128	0	CD4	41,44	gp120	30,35	CD4	gp120	12504(Tax:10090)	3700	Gene	Gene	and/or|compound|START_ENTITY END_ENTITY|nmod|and/or	Non-covalent complexes of HIV gp120 with CD4 and/or mAbs enhance activation of gp120-specific T clones and provide intermolecular help for anti-CD4 antibody production .
7903379	0	CD4	92,95	gp120	127,132	CD4	gp120	920	3700	Gene	Gene	lines|compound|START_ENTITY lines|nmod|HIV HIV|nummod|END_ENTITY	Dendritic cells are potent antigen-presenting cells for in vitro induction of primary human CD4 + T-cell lines specific for HIV gp120 .
7904351	0	CD4	45,48	gp120	58,63	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	chimeras|nmod|START_ENTITY recognition|nmod|chimeras recognition|nmod|HIV-1 HIV-1|nummod|END_ENTITY	The recognition of chimeras of rat and human CD4 by HIV-1 gp120 and by monoclonal antibodies .
7907597	0	CD4	43,46	gp120	91,96	CD4	gp120	920	3700	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing Targeting|nmod|cells Targeting|dep|using using|dobj|END_ENTITY	Targeting of liposomes to cells expressing CD4 using glycosylphosphatidylinositol-anchored gp120 .
7907660	0	CD4	76,79	gp120	6,11	CD4	gp120	920	3700	Gene	Gene	lymphocytes|compound|START_ENTITY induce|nmod|lymphocytes induce|nsubj|HIV-1 HIV-1|amod|END_ENTITY	HIV-1 gp120 and anti-gp120 induce reversible unresponsiveness in peripheral CD4 T lymphocytes .
7914230	0	CD4	0,3	gp120	81,86	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	modulation|nummod|START_ENTITY modulation|nmod|lymphocytes lymphocytes|nmod|END_ENTITY	CD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120 : contribution to the immunosuppression seen in HIV-1_infection by induction of CD4 and CD3 unresponsiveness .
7914230	0	CD4	166,169	gp120	81,86	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	induction|nmod|START_ENTITY HIV-1_infection|nmod|induction unresponsiveness|amod|HIV-1_infection seen|nmod|unresponsiveness immunosuppression|acl|seen contribution|nmod|immunosuppression modulation|dep|contribution modulation|nmod|lymphocytes lymphocytes|nmod|END_ENTITY	CD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120 : contribution to the immunosuppression seen in HIV-1_infection by induction of CD4 and CD3 unresponsiveness .
8002012	0	CD4	98,101	gp120	67,72	CD4	gp120	920	3700	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	Construction and characterization of M13 bacteriophages displaying gp120 binding domains of human CD4 .
8035496	0	CD4	71,74	gp120	106,111	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	neutralization|compound|START_ENTITY neutralization|nmod|END_ENTITY	Differential regulation of cellular tropism and sensitivity to soluble CD4 neutralization by the envelope gp120 of human_immunodeficiency_virus_type_1 .
8043225	0	CD4	101,104	gp120	69,74	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	binding|compound|START_ENTITY potentiated|nmod|binding potentiated|ccomp|inhibits inhibits|dobj|binding binding|nmod|antibodies antibodies|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Heparin specifically inhibits binding of V3 loop antibodies to HIV-1 gp120 , an effect potentiated by CD4 binding .
8178557	0	CD4	20,23	gp120	94,99	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	CDR3-related|nummod|START_ENTITY effects|nmod|CDR3-related peptide|nsubj|effects peptide|dep|showing showing|nmod|functions functions|amod|END_ENTITY	Multiple effects of CD4 CDR3-related peptide derivatives showing anti-HIV-1 activity on HIV-1 gp120 functions .
8349820	0	CD4	186,189	gp120	206,211	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120 .
8416385	0	CD4	92,95	gp120	83,88	CD4	gp120	920	3700	Gene	Gene	binding|compound|START_ENTITY END_ENTITY|nmod|binding	Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 binding .
8474162	0	CD4	104,107	gp120	45,50	CD4	gp120	920	3700	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope gp120 is cleaved after incubation with recombinant soluble CD4 .
8483933	0	CD4	127,130	gp120	83,88	CD4	gp120	920	3700	Gene	Gene	recognition|compound|START_ENTITY structure|dep|recognition structure|nmod|END_ENTITY	Proposed atomic structure of a truncated human immunodeficiency virus glycoprotein gp120 derived by molecular modeling : target CD4 recognition and docking mechanism .
8503188	0	CD4	113,116	gp120	57,62	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	glycoprotein|nmod|START_ENTITY glycoprotein|dobj|END_ENTITY	Conformational perturbation of the envelope glycoprotein gp120 of human_immunodeficiency_virus_type_1 by soluble CD4 and the lectin succinyl Con A .
8649438	0	CD4	98,101	gp120	77,82	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	+|compound|START_ENTITY binds|nmod|+ Design|acl:relcl|binds Design|nmod|epitope epitope|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Design and synthesis of a highly immunogenic , discontinuous epitope of HIV-1 gp120 which binds to CD4 + ve transfected cells .
8707350	0	CD4	49,52	gp120	28,33	CD4	gp120	920	3700	Gene	Gene	expression|nummod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	HIV-1 envelope glycoprotein gp120 down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor-alpha .
8986758	0	CD4	42,45	gp120	82,87	CD4	gp120	920	3700	Gene	Gene	receptors|compound|START_ENTITY receptors|acl:relcl|defective defective|nmod|HIV HIV|nummod|END_ENTITY	Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding .
9010617	0	CD4	91,94	gp120	131,136	CD4	gp120	920	3700	Gene	Gene	cells|compound|START_ENTITY binding|nmod|cells virus|amod|binding inhibitors|nmod|virus inhibitors|dep|model model|nmod|END_ENTITY	Functional design of potential inhibitors of human immunodeficiency virus -LRB- HIV -RRB- binding to CD4 + target cells : a molecular model of gp120 predicts ligand binding .
9110072	0	CD4	53,56	gp120	0,5	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY membrane|nmod|cells present|nmod|membrane present|nsubj|END_ENTITY	gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals : an immunoelectron microscopic study .
9138296	0	CD4	128,131	gp120	58,63	CD4	gp120	920	3700	Gene	Gene	cells|compound|START_ENTITY CD98|nmod|cells expression|dep|CD98 induces|dobj|expression induces|nsubj|END_ENTITY	Human_immunodeficiency_virus_type-1 envelope glycoprotein gp120 induces expression of fusion regulatory protein -LRB- FRP -RRB- -1 / CD98 on CD4 + T cells : a possible regulatory mechanism of HIV-induced syncytium formation .
9209479	0	CD4	13,16	gp120	69,74	CD4	gp120	12504(Tax:10090)	3700	Gene	Gene	depletion|compound|START_ENTITY Induction|nmod|depletion Induction|nmod|END_ENTITY	Induction of CD4 + T cell depletion in mice doubly transgenic for HIV gp120 and human CD4 .
9268150	0	CD4	7,10	gp120	67,72	CD4	gp120	920	3700	Gene	Gene	molecules|compound|START_ENTITY molecules|nmod|improved improved|nmod|END_ENTITY	Mutant CD4 molecules with improved binding to HIV envelope protein gp120 selected by phage display .
9295204	0	CD4	122,125	gp120	57,62	CD4	gp120	920	3700	Gene	Gene	molecule|acl:relcl|START_ENTITY molecule|nummod|END_ENTITY	HIV_infection of human fetal neural cells is mediated by gp120 binding to a cell membrane-associated molecule that is not CD4 nor galactocerebroside .
9300725	0	CD4	43,46	gp120	6,11	CD4	gp120	920	3700	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4 .
9341758	0	CD4	83,86	gp120	139,144	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	cell|compound|START_ENTITY inhibition|nmod|cell beta|nmod|inhibition activation|nsubj|beta activation|nmod|END_ENTITY	Interleukin-2_receptor beta and gamma chain dysregulation during the inhibition of CD4 T cell activation by human_immunodeficiency_virus-1 gp120 .
9621091	0	CD4	185,188	gp120	161,166	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	triggering|nmod|START_ENTITY triggering|nmod|interaction interaction|nmod|END_ENTITY	The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 with cell surface CD4 .
9641677	0	CD4	68,71	gp120	20,25	CD4	gp120	920	3700	Gene	Gene	receptor|compound|START_ENTITY glycoprotein|nmod|receptor glycoprotein|nsubj|Structure Structure|nmod|envelope envelope|amod|END_ENTITY	Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody .
9692951	0	CD4	39,42	gp120	72,77	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	peptide|compound|START_ENTITY conformation|nmod|peptide studies|nmod|conformation bound|nsubj|studies bound|nmod|HIV-1 HIV-1|nummod|END_ENTITY	NMR studies on the conformation of the CD4 36-59 peptide bound to HIV-1 gp120 .
9696823	0	CD4	20,23	gp120	92,97	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of the CD4 and CXCR4 binding properties of human_immunodeficiency_virus_type_1 gp120 by deletion of the first putative alpha-helical conserved structure .
9719434	0	CD4	38,41	gp120	97,102	CD4	gp120	920	155971(Tax:11676)	Gene	Gene	T|compound|START_ENTITY binding|nmod|T cells|amod|binding Inhibition|nmod|cells directed|nsubj|Inhibition directed|nmod|C1 C1|amod|END_ENTITY	Inhibition of HIV-1 rgp120 binding to CD4 + T cells by monoclonal antibodies directed against the gp120 C1 or C4 region .
9721247	0	CD4	30,33	gp120	23,28	CD4	gp120	920	3700	Gene	Gene	HIV|nummod|START_ENTITY HIV|nummod|END_ENTITY	Interactions among HIV gp120 , CD4 , and CXCR4 : dependence on CD4 expression level , gp120 viral origin , conservation of the gp120 COOH - and NH2-termini and V1/V2 and V3 loops , and sensitivity to neutralizing antibodies .
9780207	0	CD4	74,77	gp120	15,20	CD4	gp120	920	3700	Gene	Gene	down-regulation|compound|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation .
26085685	0	CD4	34,37	gp130	15,20	CD4	gp130	920	3572	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Cell-Intrinsic gp130 Signaling on CD4 + T Cells Shapes Long-Lasting Antiviral Immunity .
1360665	0	CD4	59,62	gp160	163,168	CD4	gp160	920	2028	Gene	Gene	+|compound|START_ENTITY +|nmod|patients patients|acl|given given|dobj|vaccine vaccine|amod|END_ENTITY	Enhancement of human immunodeficiency virus -LRB- HIV -RRB- - specific CD4 + and CD8 + cytotoxic T-lymphocyte activities in HIV-infected asymptomatic patients given recombinant gp160 vaccine .
1677023	0	CD4	14,17	gp160	79,84	CD4	gp160	920	2028	Gene	Gene	activation|compound|START_ENTITY Inhibition|nmod|activation derived|nsubj|Inhibition derived|nmod|END_ENTITY	Inhibition of CD4 + T cell activation and adhesion by peptides derived from the gp160 .
1895408	0	CD4	48,51	gp160	70,75	CD4	gp160	920	2028	Gene	Gene	proteins|nmod|START_ENTITY transport|nmod|proteins Disturbance|nmod|transport +|nsubj|Disturbance +|dobj|cells cells|acl|expressing expressing|dobj|END_ENTITY	Disturbance of nuclear transport of proteins in CD4 + cells expressing gp160 of human immunodeficiency virus .
1968506	0	CD4	114,117	gp160	104,109	CD4	gp160	920	155971(Tax:11676)	Gene	Gene	recognition|compound|START_ENTITY END_ENTITY|nmod|recognition	Anchor sequence-dependent endogenous processing of human_immunodeficiency_virus_1 envelope glycoprotein gp160 for CD4 + T cell recognition .
2190315	0	CD4	13,16	gp160	79,84	CD4	gp160	920	2028	Gene	Gene	Induction|nmod|START_ENTITY +|nsubj|Induction +|nmod|vaccine vaccine|amod|END_ENTITY	Induction of CD4 + human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine .
2243395	0	CD4	106,109	gp160	95,100	CD4	gp160	920	155971(Tax:11676)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Intracellular interaction of human_immunodeficiency_virus_type_1 -LRB- ARV-2 -RRB- envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane .
2243395	0	CD4	148,151	gp160	95,100	CD4	gp160	920	155971(Tax:11676)	Gene	Gene	movement|nmod|START_ENTITY blocks|dobj|movement blocks|nsubj|interaction interaction|nmod|END_ENTITY	Intracellular interaction of human_immunodeficiency_virus_type_1 -LRB- ARV-2 -RRB- envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane .
7504739	0	CD4	21,24	gp160	43,48	CD4	gp160	920	155971(Tax:11676)	Gene	Gene	cells|nummod|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	Apoptosis induced in CD4 + cells expressing gp160 of human_immunodeficiency_virus_type_1 .
7543487	0	CD4	145,148	gp160	75,80	CD4	gp160	920	2028	Gene	Gene	binding|nsubj|START_ENTITY preserving|xcomp|binding facilitates|advcl|preserving facilitates|nsubj|Attachment Attachment|nmod|epitope epitope|nmod|C-terminus C-terminus|nmod|END_ENTITY	Attachment of an oligopeptide epitope to the C-terminus of recombinant SIV gp160 facilitates the construction of SMAA complexes while preserving CD4 binding .
8099941	0	CD4	6,9	gp160	85,90	CD4	gp160	920	2028	Gene	Gene	+|nsubj|START_ENTITY +|dobj|responses responses|nmod|vaccine vaccine|amod|END_ENTITY	Human CD4 + cytolytic T lymphocyte responses to a human_immunodeficiency_virus_type_1 gp160 subunit vaccine .
8178478	0	CD4	68,71	gp160	18,23	CD4	gp160	920	155971(Tax:11676)	Gene	Gene	induction|nmod|START_ENTITY HIV_type_1|nmod|induction END_ENTITY|nmod|HIV_type_1	The difference in gp160 and gp120 of HIV_type_1 in the induction of CD4 downregulation preceding single-cell killing .
8661397	0	CD4	67,70	gp160	22,27	CD4	gp160	920	2028	Gene	Gene	transport|compound|START_ENTITY prevent|dobj|transport necessary|xcomp|prevent necessary|nsubj|anchorage anchorage|nmod|END_ENTITY	Membrane anchorage of gp160 is necessary and sufficient to prevent CD4 transport to the cell surface .
8755538	0	CD4	98,101	gp160	78,83	CD4	gp160	920	155971(Tax:11676)	Gene	Gene	T|compound|START_ENTITY encoding|nmod|T encoding|dobj|protease protease|nmod|processing processing|amod|END_ENTITY	Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4 + T lymphocytes .
8862395	0	CD4	79,82	gp_160	101,107	CD4	gp 160	920	2028	Gene	Gene	cells|nummod|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	Induction of apoptosis by calmodulin-dependent intracellular Ca2 + elevation in CD4 + cells expressing gp_160 of HIV .
18490721	0	CD4	46,49	granulysin	19,29	CD4	granulysin	920	10578	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Late expression of granulysin by microbicidal CD4 + T cells requires PI3K - and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients .
19616200	0	CD4	11,14	granzyme_B	61,71	CD4	granzyme B	920	3002	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
24999042	0	CD4	74,77	granzyme_B	36,46	CD4	granzyme B	920	3002	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|amod|END_ENTITY	HIV replication in conjunction with granzyme_B production by CCR5 + memory CD4 T cells : Implications for bystander cell and tissue pathologies .
12586632	0	CD4	56,59	hTERT	8,13	CD4	hTERT	920	7015	Gene	Gene	helper|compound|START_ENTITY span|nmod|helper extends|dobj|span extends|nsubj|expression expression|compound|END_ENTITY	Ectopic hTERT expression extends the life span of human CD4 + helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis .
22934259	0	CD4	11,14	hTERT	113,118	CD4	hTERT	920	7015	Gene	Gene	reactivity|compound|START_ENTITY epitopes|nsubj|reactivity epitopes|nmod|vaccination vaccination|nmod|patients patients|nmod|GV1001 GV1001|compound|END_ENTITY	Widespread CD4 + T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001 .
22934259	0	CD4	11,14	hTERT	43,48	CD4	hTERT	920	7015	Gene	Gene	reactivity|compound|START_ENTITY reactivity|nmod|END_ENTITY	Widespread CD4 + T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001 .
26662465	0	CD4	46,49	hTERT	9,14	CD4	hTERT	920	7015	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Declined hTERT expression of peripheral blood CD4 -LRB- + -RRB- T cells in oral lichen planus correlated with clinical parameter .
25641586	0	CD4	104,107	heme_oxygenase_1	34,50	CD4	heme oxygenase 1	12504(Tax:10090)	15368(Tax:10090)	Gene	Gene	function|compound|START_ENTITY restoring|dobj|function required|advcl|restoring required|nsubjpass|control control|nmod|END_ENTITY	Micro-RNA-155-mediated control of heme_oxygenase_1 -LRB- HO-1 -RRB- is required for restoring adaptively tolerant CD4 -LRB- + -RRB- T-cell function in rodents .
18341654	0	CD4	5,8	hsc70	75,80	CD4	hsc70	12504(Tax:10090)	15481(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Both CD4 + and CD8 + T cell epitopes fused to heat_shock cognate protein 70 -LRB- hsc70 -RRB- can function to eradicate tumors .
3267012	0	CD4	54,57	hybridoma_suppressor_factor	6,33	CD4	hybridoma suppressor factor	920	3569	Gene	Gene	cells|compound|START_ENTITY acts|nmod|cells acts|nsubj|END_ENTITY	Human hybridoma_suppressor_factor acts selectively on CD4 + cells .
17879278	0	CD4	128,131	iNOS	72,76	CD4	iNOS	12504(Tax:10090)	18126(Tax:10090)	Gene	Gene	transfer|nmod|START_ENTITY cells|nmod|transfer synthase|nmod|cells synthase|appos|END_ENTITY	Early bacterial dependent induction of inducible nitric_oxide synthase -LRB- iNOS -RRB- in epithelial cells upon transfer of CD45RB -LRB- high -RRB- CD4 -LRB- + -RRB- T cells in a model for experimental colitis .
20888597	0	CD4	32,35	iNOS	106,110	CD4	iNOS	12504(Tax:10090)	18126(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY saline|nmod|Foxp3 Effects|nmod|saline +|nsubj|Effects +|nmod|END_ENTITY	Effects of hypertonic saline on CD4 + CD25 + Foxp3 + regulatory T cells after hemorrhagic_shock in relation to iNOS and cytokines .
25278453	0	CD4	19,22	iNOS	0,4	CD4	iNOS	12504(Tax:10090)	18126(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	iNOS expression in CD4 + T cells limits T-reg induction by repressing TGFb-1 : combined iNOS inhibition and T-reg depletion unmask endogenous anti-tumor immunity .
25278453	0	CD4	19,22	iNOS	86,90	CD4	iNOS	12504(Tax:10090)	18126(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells limits|nsubj|expression limits|parataxis|endogenous endogenous|nsubj|inhibition inhibition|amod|END_ENTITY	iNOS expression in CD4 + T cells limits T-reg induction by repressing TGFb-1 : combined iNOS inhibition and T-reg depletion unmask endogenous anti-tumor immunity .
20116985	0	CD4	14,17	inducible_costimulator	61,83	CD4	inducible costimulator	920	29851	Gene	Gene	activation|compound|START_ENTITY Regulation|nmod|activation function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of CD4 T cell activation and effector function by inducible_costimulator -LRB- ICOS -RRB- .
20445113	0	CD4	70,73	inducible_costimulator	27,49	CD4	inducible costimulator	920	29851	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression and function of inducible_costimulator on peripheral blood CD4 + T cells in Beh et 's patients with uveitis : a new activity marker ?
21871023	0	CD4	50,53	inducible_costimulator	24,46	CD4	inducible costimulator	920	29851	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Ribavirin downmodulates inducible_costimulator on CD4 + T cells and their interleukin-10 secretion to assist in hepatitis_C virus clearance .
25035167	0	CD4	64,67	inducible_nitric_oxide_synthase	87,118	CD4	inducible nitric oxide synthase	12504(Tax:10090)	18126(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	SSC -LRB- high -RRB- CD11b -LRB- high -RRB- Ly-6C -LRB- high -RRB- Ly-6G -LRB- low -RRB- myeloid cells curtail CD4 T cell response by inducible_nitric_oxide_synthase in murine hepatitis .
14691297	0	CD4	104,107	intercellular_adhesion_molecule-1	13,46	CD4	intercellular adhesion molecule-1	920	3383	Gene	Gene	coreceptors|compound|START_ENTITY role|nmod|coreceptors Induction|dep|role Induction|nmod|cells cells|amod|END_ENTITY	Induction of intercellular_adhesion_molecule-1 on human brain endothelial cells by HIV-1 gp120 : role of CD4 and chemokine coreceptors .
16895560	0	CD4	29,32	intercellular_adhesion_molecule-1	49,82	CD4	intercellular adhesion molecule-1	920	3383	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Costimulation of naive human CD4 T cells through intercellular_adhesion_molecule-1 promotes differentiation to a memory phenotype that is not strictly the result of multiple rounds of cell division .
22804504	0	CD4	73,76	intercellular_adhesion_molecule-1	120,153	CD4	intercellular adhesion molecule-1	920	3383	Gene	Gene	T-cell|compound|START_ENTITY motility|nsubj|T-cell motility|advcl|regulating regulating|nmod|END_ENTITY	Wiskott-Aldrich_syndrome protein controls antigen-presenting cell-driven CD4 + T-cell motility by regulating adhesion to intercellular_adhesion_molecule-1 .
7689606	0	CD4	161,164	intercellular_adhesion_molecule-1	36,69	CD4	intercellular adhesion molecule-1	920	3383	Gene	Gene	lymphocytes|compound|START_ENTITY death|nmod|lymphocytes augments|dobj|death augments|nsubj|Costimulation Costimulation|nmod|ligands ligands|amod|END_ENTITY	Costimulation with integrin ligands intercellular_adhesion_molecule-1 or vascular_cell_adhesion_molecule-1 augments activation-induced death of antigen-specific CD4 + T lymphocytes .
7915884	0	CD4	30,33	intercellular_adhesion_molecule_1	51,84	CD4	intercellular adhesion molecule 1	12504(Tax:10090)	15894(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of monoclonal antibody CD4 on expression of intercellular_adhesion_molecule_1 in renal tissues of ddY mice : a spontaneous animal model of IgA_nephropathy .
1360995	0	CD4	74,77	intercellular_cell_adhesion_molecule-1	137,175	CD4	intercellular cell adhesion molecule-1	920	3383	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Costimulation of T cell receptor/CD3-mediated activation of resting human CD4 + T cells by leukocyte function-associated antigen-1 ligand intercellular_cell_adhesion_molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increase of intracellular Ca2 + levels .
10233697	0	CD4	112,115	interferon-gamma	57,73	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY human|appos|+ enhances|nmod|human enhances|dobj|expression expression|nmod|END_ENTITY	Interleukin-15 differentially enhances the expression of interferon-gamma and interleukin-4 in activated human -LRB- CD4 + -RRB- T lymphocytes .
10479527	0	CD4	0,3	interferon-gamma	36,52	CD4	interferon-gamma	920	3458	Gene	Gene	T|nsubj|START_ENTITY T|dep|producing producing|dobj|predominate predominate|amod|END_ENTITY	CD4 -LRB- + -RRB- T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary_tuberculosis patients .
10540183	0	CD4	19,22	interferon-gamma	37,53	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|cells cells|nmod|END_ENTITY	In vitro activated CD4 + T cells from interferon-gamma -LRB- IFN-gamma -RRB- - deficient mice induce intestinal_inflammation in immunodeficient hosts .
10692120	0	CD4	5,8	interferon-gamma	26,42	CD4	interferon-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|END_ENTITY	Skin CD4 + T cells produce interferon-gamma in vitro in response to streptococcal antigens in chronic_plaque_psoriasis .
10755571	0	CD4	0,3	interferon-gamma	104,120	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ mediate|nsubj|cells mediate|dobj|rejection rejection|nmod|absence absence|nmod|END_ENTITY	CD4 + T cells responsive through the indirect pathway can mediate skin graft rejection in the absence of interferon-gamma .
10809917	0	CD4	131,134	interferon-gamma	69,85	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY +|nsubj|numbers numbers|acl|expressing expressing|dobj|mRNA mRNA|amod|END_ENTITY	Increased numbers of mononuclear cells from blood and CSF expressing interferon-gamma mRNA in multiple_sclerosis are from both the CD4 + and the CD8 + subsets .
10895055	0	CD4	89,92	interferon-gamma	26,42	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY purified|dobj|+ secretion|advcl|purified secretion|nsubj|changes changes|nmod|END_ENTITY	Age-associated changes in interferon-gamma and interleukin-4 secretion by purified human CD4 + and CD8 + T cells .
11412302	0	CD4	47,50	interferon-gamma	27,43	CD4	interferon-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Preferential production of interferon-gamma by CD4 + T cells expressing the homing receptor integrin_alpha4 / beta7 .
11852193	0	CD4	89,92	interferon-gamma	138,154	CD4	interferon-gamma	407098(Tax:9913)	281237(Tax:9913)	Gene	Gene	+|compound|START_ENTITY enriched|dep|+ enriched|xcomp|proliferate proliferate|dobj|END_ENTITY	Low molecular weight proteins of Cowdria_ruminantium -LRB- Welgevonden isolate -RRB- induce bovine CD4 + - enriched T-cells to proliferate and produce interferon-gamma .
12525871	0	CD4	139,142	interferon-gamma	97,113	CD4	interferon-gamma	920	3458	Gene	Gene	clone|compound|START_ENTITY inhibits|nmod|clone inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Transforming_growth_factor-beta released by PPD-presenting malignant_mesothelioma cells inhibits interferon-gamma synthesis by an anti-PPD CD4 + T-cell clone .
1370259	0	CD4	21,24	interferon-gamma	100,116	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|compound|START_ENTITY depletion|nmod|T increases|nmod|depletion increases|parataxis|role role|nmod|END_ENTITY	In vivo depletion of CD4 T cells increases B cell sensitivity to polyclonal activation : the role of interferon-gamma .
1432999	0	CD4	88,91	interferon-gamma	57,73	CD4	interferon-gamma	920	3458	Gene	Gene	positive|compound|START_ENTITY inhibit|nmod|positive inhibit|dobj|production production|amod|END_ENTITY	Cyclosporine and chloroquine synergistically inhibit the interferon-gamma production by CD4 positive and CD8 positive synovial T cell clones derived from a patient with rheumatoid_arthritis .
15493262	0	CD4	76,79	interferon-gamma	8,24	CD4	interferon-gamma	920	3458	Gene	Gene	CDw29|compound|START_ENTITY Maximal|nmod|CDw29 Maximal|dobj|production production|amod|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
15502111	0	CD4	71,74	interferon-gamma	44,60	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Increased interleukin-4 , interleukin-5 , and interferon-gamma in airway CD4 + and CD8 + T cells in atopic_asthma .
15649266	0	CD4	62,65	interferon-gamma	79,95	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY recruitment|nmod|+ induces|dobj|recruitment induces|parataxis|+ +|nsubj|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15829292	0	CD4	146,149	interferon-gamma	29,45	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY paralleled|nmod|cells paralleled|nsubj|suppression suppression|nmod|production production|amod|END_ENTITY	Tumor-induced suppression of interferon-gamma production and enhancement of interleukin-10 production by natural killer -LRB- NK -RRB- cells : paralleled to CD4 + T cells .
15935691	0	CD4	77,80	interferon-gamma	34,50	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|amod|END_ENTITY	Correlation between intracellular interferon-gamma -LRB- IFN-gamma -RRB- production by CD4 + and CD8 + lymphocytes and IFN-gamma gene polymorphism in patients with type 2 diabetes_mellitus and latent autoimmune diabetes of adults -LRB- LADA -RRB- .
16162267	0	CD4	80,83	interferon-gamma	40,56	CD4	interferon-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY retention|nmod|cells retention|amod|END_ENTITY	A novel mechanism of immune regulation : interferon-gamma regulates retention of CD4 T cells during delayed_type_hypersensitivity .
1672641	0	CD4	65,68	interferon-gamma	133,149	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	lines|compound|START_ENTITY lines|acl:relcl|secrete secrete|dobj|END_ENTITY	Exacerbation of experimental murine cutaneous_leishmaniasis with CD4 + Leishmania_major-specific T cell lines or clones which secrete interferon-gamma and mediate parasite-specific delayed-type_hypersensitivity .
17533522	0	CD4	63,66	interferon-gamma	14,30	CD4	interferon-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY Expression|nmod|cells Expression|nmod|production production|compound|END_ENTITY	Expression of interferon-gamma and interleukin-4 production in CD4 + T cells in patients with chronic_heart_failure .
17617612	0	CD4	56,59	interferon-gamma	7,23	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY enhances|dobj|+ enhances|nsubj|END_ENTITY	Direct interferon-gamma signaling dramatically enhances CD4 + and CD8 + T cell memory .
18179752	0	CD4	99,102	interferon-gamma	53,69	CD4	interferon-gamma	920	3458	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Effect of coronary percutaneous revascularization on interferon-gamma and interleukin-10 producing CD4 + T cells during acute myocardial_infarction .
19003102	0	CD4	50,53	interferon-gamma	76,92	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY ve|dobj|+ prime|xcomp|ve prime|xcomp|produce produce|dobj|END_ENTITY	Murine Peyer 's patch dendritic cells prime na ve CD4 -LRB- + -RRB- T cells to produce interferon-gamma .
19909079	0	CD4	41,44	interferon-gamma	69,85	CD4	interferon-gamma	920	3458	Gene	Gene	frequency|nmod|START_ENTITY increase|nmod|frequency T|nsubj|increase T|dobj|cells cells|acl:relcl|produce produce|dobj|END_ENTITY	Age-related increase in the frequency of CD4 -LRB- + -RRB- T cells that produce interferon-gamma in response to staphylococcal enterotoxin B during childhood .
19939720	0	CD4	129,132	interferon-gamma	58,74	CD4	interferon-gamma	920	3458	Gene	Gene	syndrome|compound|START_ENTITY patient|nmod|syndrome relapsing|nmod|patient relapsing|nmod|END_ENTITY	Treatment of relapsing Mycobacterium_avium infection with interferon-gamma and interleukin-2 in an HIV-negative patient with low CD4 syndrome .
20178622	0	CD4	10,13	interferon-gamma	75,91	CD4	interferon-gamma	920	3458	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|enhance enhance|nmod|cooperation cooperation|nmod|END_ENTITY	Activated CD4 + T cells enhance radiation effect through the cooperation of interferon-gamma and TNF-alpha .
20634047	0	CD4	46,49	interferon-gamma	10,26	CD4	interferon-gamma	920	3458	Gene	Gene	T-cells|compound|START_ENTITY Detecting|nmod|T-cells Detecting|dobj|release release|amod|END_ENTITY	Detecting interferon-gamma release from human CD4 T-cells using surface plasmon resonance .
2122929	0	CD4	57,60	interferon-gamma	96,112	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	clone|compound|START_ENTITY tumours|nmod|clone Cytostasis|nmod|tumours mediated|nsubj|Cytostasis mediated|nmod|END_ENTITY	Cytostasis of different tumours by a murine PPD-reactive CD4 + T lymphocyte clone is mediated by interferon-gamma and tumour_necrosis_factor alone or synergistically .
2523864	0	CD4	160,163	interferon-gamma	100,116	CD4	interferon-gamma	920	3458	Gene	Gene	+45|compound|START_ENTITY R|nummod|+45 activated|dobj|R IL-2|acl|activated restricted|nmod|IL-2 restricted|nsubjpass|production production|amod|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	CD4	23,26	interferon-gamma	100,116	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY Proliferation|nmod|+ T|nsubj|Proliferation T|parataxis|promoted promoted|advcl|restricted restricted|nsubjpass|production production|amod|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
7522637	0	CD4	17,20	interferon-gamma	93,109	CD4	interferon-gamma	920	3458	Gene	Gene	molecules|nummod|START_ENTITY Cross-linking|nmod|molecules upregulates|nsubj|Cross-linking upregulates|advcl|inducing inducing|dobj|secretion secretion|amod|END_ENTITY	Cross-linking of CD4 molecules upregulates Fas_antigen expression in lymphocytes by inducing interferon-gamma and tumor_necrosis_factor-alpha secretion .
7583443	0	CD4	0,3	interferon-gamma	80,96	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY increased|nsubj|+ increased|dobj|amounts amounts|nmod|END_ENTITY	CD4 + and CD8 + lymphocytes of patients with AIDS synthesize increased amounts of interferon-gamma .
7605995	0	CD4	80,83	interferon-gamma	25,41	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ chemotactic|nmod|lymphocytes END_ENTITY|appos|chemotactic	Cytokine loops involving interferon-gamma and IP-10 , a cytokine chemotactic for CD4 + lymphocytes : an explanation for the epidermotropism of cutaneous_T-cell_lymphoma ?
7657839	0	CD4	79,82	interferon-gamma	17,33	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY interleukin-12|nmod|+ clones|amod|interleukin-12 induced|nmod|clones induced|csubj|Priming Priming|nmod|production production|amod|END_ENTITY	Priming for high interferon-gamma production induced by interleukin-12 in both CD4 + and CD8 + T cell clones from HIV-infected patients .
8101473	0	CD4	31,34	interferon-gamma	137,153	CD4	interferon-gamma	920	3458	Gene	Gene	cytotoxic|compound|START_ENTITY Detection|nmod|cytotoxic T|nsubj|Detection T|nmod|assay assay|nmod|targets targets|nmod|END_ENTITY	Detection of melanoma-reactive CD4 + HLA-class I-restricted cytotoxic T cell clones with long-term assay and pretreatment of targets with interferon-gamma .
8537685	0	CD4	41,44	interferon-gamma	126,142	CD4	interferon-gamma	920	3458	Gene	Gene	targets|nmod|START_ENTITY lymphocyte|nsubj|targets lymphocyte|nmod|keratinocytes keratinocytes|acl|treated treated|nmod|END_ENTITY	Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-gamma .
8552982	0	CD4	36,39	interferon-gamma	9,25	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY producing|dobj|+ END_ENTITY|acl|producing	Specific interferon-gamma producing CD4 + and CD8 + T cells after autologous EBV-B stimulation : the necessity of restimulation .
8676077	0	CD4	28,31	interferon-gamma	82,98	CD4	interferon-gamma	920	3458	Gene	Gene	primes|dobj|START_ENTITY primes|nmod|production production|nmod|END_ENTITY	Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10 .
8826970	0	CD4	5,8	interferon-gamma	73,89	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY produce|nsubj|+ produce|dobj|END_ENTITY	Both CD4 + and CD8 + T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction .
9466535	0	CD4	0,3	interferon-gamma	77,93	CD4	interferon-gamma	920	3458	Gene	Gene	lymphocytes|compound|START_ENTITY have|nsubj|lymphocytes have|dobj|production production|amod|END_ENTITY	CD4 T lymphocytes from patients with chronic_fatigue_syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone .
9616216	0	CD4	122,125	interferon-gamma	138,154	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|dep|cells cells|appos|END_ENTITY	Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4 -LRB- + -RRB- T cells , interferon-gamma , and CTLA4 .
9824051	0	CD4	10,13	interferon-gamma	140,156	CD4	interferon-gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|associated associated|xcomp|secreting secreting|dobj|END_ENTITY	Cytotoxic CD4 + T cells associated with the expression of major histocompatibility complex class II antigen of mouse myeloma cells secreting interferon-gamma are cytolytic in vitro and tumoricidal in vivo .
9856819	0	CD4	113,116	interferon-gamma	35,51	CD4	interferon-gamma	920	3458	Gene	Gene	+|compound|START_ENTITY localization|nmod|+ Identification|dep|localization Identification|nmod|cells cells|amod|END_ENTITY	Identification and quantitation of interferon-gamma producing T cells in psoriatic lesions : localization to both CD4 + and CD8 + subsets .
9889405	0	CD4	76,79	interferon-gamma	42,58	CD4	interferon-gamma	24932(Tax:10116)	25712(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY analysis|nmod|cells analysis|nmod|synthesis synthesis|amod|END_ENTITY	Flow cytometric analysis of intracellular interferon-gamma synthesis in rat CD4 T cells .
2109036	0	CD4	9,12	interferon_gamma	85,101	CD4	interferon gamma	12504(Tax:10090)	15978(Tax:10090)	Gene	Gene	+|compound|START_ENTITY Roles|nmod|+ Roles|nmod|END_ENTITY	Roles of CD4 + and CD8 + cells , and the effect of administration of recombinant murine interferon_gamma in listerial infection .
11979045	0	CD4	48,51	interleukin-10	12,26	CD4	interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	+|compound|START_ENTITY generation|nmod|+ END_ENTITY|nmod|generation	The role of interleukin-10 in the generation of CD4 + and CD8 + memory_T cells -LRB- expressing a CD44 + , CD62L - phenotype -RRB- and their contribution to the regulation of immunoglobulin E antibody formation .
12438963	0	CD4	79,82	interleukin-10	37,51	CD4	interleukin-10	920	3586	Gene	Gene	cells|compound|START_ENTITY activities|nmod|cells activities|nmod|END_ENTITY	Synergistic inhibitory activities of interleukin-10 and dexamethasone on human CD4 + T cells .
15298560	0	CD4	96,99	interleukin-10	107,121	CD4	interleukin-10	920	3586	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Induction of T ` regulatory ' cells by standardized house dust mite immunotherapy : an increase in CD4 + CD25 + interleukin-10 + T cells expressing peripheral tissue trafficking markers .
15556685	0	CD4	174,177	interleukin-10	78,92	CD4	interleukin-10	920	3586	Gene	Gene	cells|compound|START_ENTITY activating|dobj|cells suppress|advcl|activating suppress|nsubj|cells cells|acl|engineered engineered|xcomp|secrete secrete|xcomp|END_ENTITY	Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 -LRB- IL-10 -RRB- suppress Th1-type responses while selectively activating IL-10-producing CD4 + T cells .
15829292	0	CD4	146,149	interleukin-10	76,90	CD4	interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY paralleled|nmod|cells paralleled|nsubj|suppression suppression|nmod|production production|amod|END_ENTITY	Tumor-induced suppression of interferon-gamma production and enhancement of interleukin-10 production by natural killer -LRB- NK -RRB- cells : paralleled to CD4 + T cells .
17671115	0	CD4	19,22	interleukin-10	56,70	CD4	interleukin-10	920	3586	Gene	Gene	CD25highFoxp3|compound|START_ENTITY subset|nmod|CD25highFoxp3 +|nsubj|subset +|dep|secreting secreting|dobj|suppression suppression|amod|END_ENTITY	A unique subset of CD4 + CD25highFoxp3 + T cells secreting interleukin-10 and transforming_growth_factor-beta1 mediates suppression in the tumor microenvironment .
17996686	0	CD4	81,84	interleukin-10	52,66	CD4	interleukin-10	920	3586	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	1,25-dihydroxyvitamin _ D3 and dexamethasone increase interleukin-10 production in CD4 + T cells from patients with Crohn 's _ disease .
18824533	0	CD4	103,106	interleukin-10	144,158	CD4	interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY role|nmod|Foxp3 +|nsubj|role +|xcomp|independent independent|advcl|END_ENTITY	Schistosoma_mansoni antigens modulate experimental allergic_asthma in a murine model : a major role for CD4 + CD25 + Foxp3 + T cells independent of interleukin-10 .
19667950	0	CD4	57,60	interleukin-10	10,24	CD4	interleukin-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY expansion|nmod|CD25 production|nmod|expansion production|amod|END_ENTITY	Increased interleukin-10 production without expansion of CD4 + CD25 + T-regulatory cells in early stable renal transplant patients on calcineurin inhibitors .
20528588	0	CD4	12,15	interleukin-10	53,67	CD4	interleukin-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY defect|nmod|CD25 +|nsubj|defect +|advcl|inducing inducing|dobj|production production|amod|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
20528588	0	CD4	84,87	interleukin-10	53,67	CD4	interleukin-10	920	3586	Gene	Gene	cells|compound|START_ENTITY inducing|nmod|cells inducing|dobj|production production|amod|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
20722024	0	CD4	24,27	interleukin-10	111,125	CD4	interleukin-10	920	3586	Gene	Gene	CD25|compound|START_ENTITY Expansion|nmod|CD25 cells|dep|Expansion role|dep|cells role|nmod|response response|amod|END_ENTITY	Expansion of intestinal CD4 + CD25 -LRB- high -RRB- Treg cells in patients with ankylosing_spondylitis : a putative role for interleukin-10 in preventing intestinal Th17 response .
21718313	0	CD4	53,56	interleukin-10	10,24	CD4	interleukin-10	920	3586	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Increased interleukin-10 production by ASC-deficient CD4 + T cells impairs bystander T-cell proliferation .
21982068	0	CD4	94,97	interleukin-10	18,32	CD4	interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY percentages|nmod|Foxp3 +|nsubj|percentages decreases|ccomp|+ decreases|nsubj|Neutralization Neutralization|nmod|factor-b factor-b|amod|END_ENTITY	Neutralization of interleukin-10 or transforming growth factor-b decreases the percentages of CD4 + CD25 + Foxp3 + regulatory T cells in septic mice , thereby leading to an improved survival .
22209878	0	CD4	63,66	interleukin-10	35,49	CD4	interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	produced|nmod|START_ENTITY role|acl|produced role|nmod|END_ENTITY	Regulatory role of antigen-induced interleukin-10 , produced by CD4 -LRB- + -RRB- T cells , in airway neutrophilia in a murine model for asthma .
24352453	0	CD4	77,80	interleukin-10	35,49	CD4	interleukin-10	920	3586	Gene	Gene	cell|compound|START_ENTITY and/or|nmod|cell and/or|dobj|blockade blockade|amod|END_ENTITY	Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions .
25024370	0	CD4	58,61	interleukin-10	19,33	CD4	interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY antigen-specific|dobj|expansion antigen-specific|nsubj|induction induction|nmod|limits limits|amod|END_ENTITY	Early induction of interleukin-10 limits antigen-specific CD4 T cell expansion , function , and secondary recall responses during persistent phagosomal infection .
25861842	0	CD4	21,24	interleukin-10	129,143	CD4	interleukin-10	12504(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|dep|induced induced|advcl|require require|xcomp|END_ENTITY	Alloantigen-specific CD4 -LRB- + -RRB- regulatory T cells induced in vivo by ultraviolet irradiation after alloantigen immunization require interleukin-10 for their induction and activation , and flexibly mediate bystander immunosuppression of allograft rejection .
8639843	0	CD4	70,73	interleukin-10	42,56	CD4	interleukin-10	920	3586	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Interferon-alpha stimulates production of interleukin-10 in activated CD4 + T cells and monocytes .
9436700	0	CD4	63,66	interleukin-10	11,25	CD4	interleukin-10	920	3586	Gene	Gene	T|compound|START_ENTITY decrease|nmod|T increases|nmod|decrease increases|amod|END_ENTITY	Peritoneal interleukin-10 increases with decrease in activated CD4 + T lymphocytes in women with endometriosis .
24034921	0	CD4	112,115	interleukin-13	64,78	CD4	interleukin-13	920	3596	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- 1,25 - -LRB- OH -RRB- 2D3 inhibits lipopolysaccharide-induced expression of interleukin-13 and interleukin-17 in cord blood CD4 + T cells -RSB- .
10233698	0	CD4	67,70	interleukin-16	21,35	CD4	interleukin-16	920	3603	Gene	Gene	T|compound|START_ENTITY production|nmod|T END_ENTITY|nmod|production	Inhibitory effect of interleukin-16 on interleukin-2 production by CD4 + T cells .
22170065	0	CD4	117,120	interleukin-17	84,98	CD4	interleukin-17	12504(Tax:10090)	16171(Tax:10090)	Gene	Gene	+|compound|START_ENTITY producing|dobj|+ regulates|parataxis|producing regulates|nmod|differentiation differentiation|nmod|END_ENTITY	Transforming growth factor-b protein inversely regulates in vivo differentiation of interleukin-17 -LRB- IL-17 -RRB- - producing CD4 + and CD8 + T cells .
22321808	0	CD4	0,3	interleukin-17	46,60	CD4	interleukin-17	404704(Tax:9823)	449530(Tax:9823)	Gene	Gene	+|compound|START_ENTITY sources|nsubj|+ sources|nmod|END_ENTITY	CD4 + and y TCR + T lymphocytes are sources of interleukin-17 in swine .
24102576	0	CD4	69,72	interleukin-17	12,26	CD4	interleukin-17	920	3605	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Recovery of interleukin-17 production from interleukin-15-stimulated CD4 + mononuclear cells in HIV-1-infected patients with sustained viral suppression .
24338253	0	CD4	107,110	interleukin-17	78,92	CD4	interleukin-17	920	3605	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	The effects of vitamin_D on allergen-induced expression of interleukin-13 and interleukin-17 in cord blood CD4 T cells .
10197373	0	CD4	42,45	interleukin-2	99,112	CD4	interleukin-2	920	3558	Gene	Gene	T|compound|START_ENTITY expression|nmod|T upregulation|nmod|expression lymphocytes|nsubj|upregulation lymphocytes|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	Acute upregulation of CCR-5 expression by CD4 + T lymphocytes in HIV-infected patients treated with interleukin-2 .
10233698	0	CD4	67,70	interleukin-2	39,52	CD4	interleukin-2	920	3558	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|compound|END_ENTITY	Inhibitory effect of interleukin-16 on interleukin-2 production by CD4 + T cells .
10353861	0	CD4	132,135	interleukin-2	34,47	CD4	interleukin-2	920	3558	Gene	Gene	cells|compound|START_ENTITY <|ccomp|cells treat|advcl|< END_ENTITY|xcomp|treat	Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human_immunodeficiency_virus_type_1 in persons with < / = 250/microL CD4 T cells and undetectable plasma virus load .
10479131	0	CD4	50,53	interleukin-2	22,35	CD4	interleukin-2	920	3558	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|compound|END_ENTITY	Restoration of normal interleukin-2 production by CD4 + T cells of human_immunodeficiency_virus-infected patients after 9 months of highly active antiretroviral therapy .
10823761	0	CD4	203,206	interleukin-2	84,97	CD4	interleukin-2	920	3558	Gene	Gene	counts|compound|START_ENTITY patients|nmod|counts >|nmod|patients comparing|dep|> comparing|nmod|END_ENTITY	A randomized , controlled , phase II trial comparing escalating doses of subcutaneous interleukin-2 plus antiretrovirals versus antiretrovirals alone in human_immunodeficiency_virus-infected patients with CD4 + cell counts > / = 350/mm3 .
11181149	0	CD4	94,97	interleukin-2	16,29	CD4	interleukin-2	920	3558	Gene	Gene	cell|compound|START_ENTITY counts|nsubj|cell therapy|acl:relcl|counts therapy|compound|END_ENTITY	Rapid effect of interleukin-2 therapy in human_immunodeficiency_virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment .
11182148	0	CD4	39,42	interleukin-2	155,168	CD4	interleukin-2	404704(Tax:9823)	396868(Tax:9823)	Gene	Gene	characterization|nmod|START_ENTITY characterization|parataxis|lymphoblastoid lymphoblastoid|nmod|phenotype phenotype|acl|generated generated|advcl|vitro vitro|nmod|END_ENTITY	Functional characterization of a swine CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- double positive lymphoblastoid T-cell line with a CD25 -LRB- + -RRB- / CD45RA -LRB- - -RRB- phenotype generated in vitro with interleukin-2 .
12383198	0	CD4	51,54	interleukin-2	13,26	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	Insufficient interleukin-2 production from splenic CD4 + T cells causes impaired cell proliferation and early apoptosis in SAMP1 , a strain of senescence-accelerated mouse .
12706405	0	CD4	255,258	interleukin-2	139,152	CD4	interleukin-2	920	3558	Gene	Gene	cells|compound|START_ENTITY patients|nmod|cells combined|nmod|patients combined|nsubj|cycles cycles|nmod|END_ENTITY	A randomized controlled trial evaluating the efficacy and safety of intermittent 3 - , 4 - , and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy -LRB- ART -RRB- versus ART alone in HIV-seropositive patients with 100-300 CD4 + T cells .
1370094	0	CD4	2,5	interleukin-2	139,152	CD4	interleukin-2	920	3558	Gene	Gene	clone|compound|START_ENTITY clone|dep|activity activity|nmod|END_ENTITY	A CD4 + cytotoxic T-lymphocyte clone to a conserved epitope on human_immunodeficiency_virus_type_1 p24 : cytotoxic activity and secretion of interleukin-2 and interleukin-6 .
14512540	0	CD4	66,69	interleukin-2	109,122	CD4	interleukin-2	920	3558	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells associated|nsubjpass|proliferation associated|nmod|END_ENTITY	Diminished proliferation of human_immunodeficiency_virus-specific CD4 + T cells is associated with diminished interleukin-2 -LRB- IL-2 -RRB- production and is recovered by exogenous IL-2 .
14523786	0	CD4	6,9	interleukin-2	70,83	CD4	interleukin-2	920	3558	Gene	Gene	count|compound|START_ENTITY predicts|nsubj|count predicts|nmod|END_ENTITY	Nadir CD4 + T cell count predicts response to subcutaneous recombinant interleukin-2 .
14600575	0	CD4	13,16	interleukin-2	106,119	CD4	interleukin-2	920	3558	Gene	Gene	lymphocytes|compound|START_ENTITY Increases|nmod|lymphocytes occur|nsubj|Increases occur|advcl|receiving receiving|dobj|therapy therapy|compound|END_ENTITY	Increases in CD4 + T lymphocytes occur without increases in thymic size in HIV-infected subjects receiving interleukin-2 therapy .
14612896	0	CD4	174,177	interleukin-2	120,133	CD4	interleukin-2	920	3558	Gene	Gene	lymphocytes|compound|START_ENTITY induction|nmod|lymphocytes immunotherapy|dep|induction immunotherapy|nmod|effusion effusion|nmod|colorectal_cancer colorectal_cancer|acl|using using|dobj|OK-432 OK-432|nmod|END_ENTITY	Locoregional immunotherapy of malignant effusion from colorectal_cancer using the streptococcal preparation OK-432 plus interleukin-2 : induction of autologous tumor-reactive CD4 + Th1 killer lymphocytes .
15493262	0	CD4	76,79	interleukin-2	59,72	CD4	interleukin-2	920	3558	Gene	Gene	CDw29|compound|START_ENTITY Maximal|nmod|CDw29 Maximal|dobj|production production|nmod|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
15753210	0	CD4	37,40	interleukin-2	19,32	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Essential role for interleukin-2 for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cell development during the neonatal period .
16320325	0	CD4	6,9	interleukin-2	86,99	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	T|compound|START_ENTITY requires|nsubj|T requires|dobj|END_ENTITY	Acute CD4 + T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4 , joint macrophages , granulocyte-macrophage_colony-stimulating_factor , interleukin-6 , and leukemia_inhibitory_factor .
16505437	0	CD4	20,23	interleukin-2	84,97	CD4	interleukin-2	920	3558	Gene	Gene	CD25|compound|START_ENTITY Characterization|nmod|CD25 +|nsubj|Characterization +|nmod|patients patients|acl|treated treated|nmod|END_ENTITY	Characterization of CD4 + CD25 + regulatory T cells in patients treated with high-dose interleukin-2 for metastatic_melanoma or renal_cell_carcinoma .
16522809	0	CD4	14,17	interleukin-2	76,89	CD4	interleukin-2	920	3558	Gene	Gene	T-cell|compound|START_ENTITY Inhibition|nmod|T-cell function|nsubj|Inhibition function|nmod|production production|compound|END_ENTITY	Inhibition of CD4 + CD25 + regulatory T-cell function by calcineurin-dependent interleukin-2 production .
17484770	0	CD4	105,108	interleukin-2	36,49	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|nmod|production production|compound|END_ENTITY	Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like_receptor_4-dependent mechanism .
18281483	0	CD4	82,85	interleukin-2	24,37	CD4	interleukin-2	920	3558	Gene	Gene	+|compound|START_ENTITY interleukin-21|nmod|+ cells|amod|interleukin-21 effects|nmod|cells effects|nmod|END_ENTITY	Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4 + cutaneous_T-cell_lymphoma cells .
22002241	0	CD4	56,59	interleukin-2	13,26	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY drives|dep|+ END_ENTITY|dep|drives	Intratumoral interleukin-2 / agonist CD40 antibody drives CD4 + - independent resolution of treated-tumors and CD4 + - dependent systemic and memory responses .
22301410	0	CD4	48,51	interleukin-2	23,36	CD4	interleukin-2	920	3558	Gene	Gene	T-cell|compound|START_ENTITY therapy|nmod|T-cell therapy|compound|END_ENTITY	Effect of intermittent interleukin-2 therapy on CD4 + T-cell counts following antiretroviral cessation in patients with HIV .
22445722	0	CD4	47,50	interleukin-2	19,32	CD4	interleukin-2	920	3558	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Down-regulation of interleukin-2 production by CD4 -LRB- + -RRB- T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription .
22851544	0	CD4	93,96	interleukin-2	22,35	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY +|nsubj|Foxp3 expands|ccomp|+ therapy|parataxis|expands therapy|nmod|END_ENTITY	Cytokine therapy with interleukin-2 / anti-interleukin-2 monoclonal antibody complexes expands CD4 + CD25 + Foxp3 + regulatory T cells and attenuates development and progression of atherosclerosis .
24853588	0	CD4	79,82	interleukin-2	51,64	CD4	interleukin-2	24932(Tax:10116)	116562(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4 -LRB- + -RRB- T cells of aged rats .
2572284	0	CD4	161,164	interleukin-2	84,97	CD4	interleukin-2	920	3558	Gene	Gene	synthesize|nmod|START_ENTITY synthesize|dobj|END_ENTITY	T-cell ontogeny after autologous bone marrow transplantation : failure to synthesize interleukin-2 -LRB- IL-2 -RRB- and lack of CD2 - and CD3-mediated proliferation by both CD4 - and CD8 + cells even in the presence of exogeneous IL-2 .
2574630	0	CD4	42,45	interleukin-2	146,159	CD4	interleukin-2	920	3558	Gene	Gene	cells|compound|START_ENTITY contain|dobj|cells contain|nmod|presence presence|nmod|END_ENTITY	Cancer patients ' lymphocytes contain CD3 + CD4 + cells that proliferate in response to autologous tumor cells in the presence of exogenous low-dose interleukin-2 and autologous accessory cells .
2904172	0	CD4	41,44	interleukin-2	13,26	CD4	interleukin-2	920	3558	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|compound|END_ENTITY	Induction of interleukin-2 production in CD4 + and CD8 + T-cell subsets after activation via CD3 and CD2 .
3100439	0	CD4	73,76	interleukin-2	10,23	CD4	interleukin-2	920	3558	Gene	Gene	lymphocytes|amod|START_ENTITY expression|nmod|lymphocytes expression|compound|END_ENTITY	Increased interleukin-2 receptor expression after mitogen stimulation on CD4 - and CD8-positive lymphocytes and decreased interleukin-2 production in HTLV-III antibody-positive symptomatic individuals .
7646637	0	CD4	13,16	interleukin-2	60,73	CD4	interleukin-2	920	3558	Gene	Gene	T|compound|START_ENTITY Increases|nmod|T lymphocytes|nsubj|Increases lymphocytes|nmod|courses courses|nmod|END_ENTITY	Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human_immunodeficiency_virus_infection .
7676498	0	CD4	153,156	interleukin-2	43,56	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	graft-versus-host-reactive|dep|START_ENTITY cells|amod|graft-versus-host-reactive associated|nmod|cells associated|nsubjpass|Inhibition Inhibition|nmod|treatment treatment|amod|graft-versus-host_disease graft-versus-host_disease|nmod|END_ENTITY	Inhibition of graft-versus-host_disease by interleukin-2 treatment is associated with altered cytokine production by expanded graft-versus-host-reactive CD4 + helper cells .
7901231	0	CD4	111,114	interleukin-2	8,21	CD4	interleukin-2	920	3558	Gene	Gene	differentiation|compound|START_ENTITY abnormality|nmod|differentiation due|nmod|abnormality due|nsubj|production production|compound|END_ENTITY	Reduced interleukin-2 -LRB- IL-2 -RRB- production in common variable immunodeficiency is due to a primary abnormality of CD4 + T cell differentiation .
7905789	0	CD4	15,18	interleukin-2	97,110	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY Elimination|nmod|cells augments|nsubj|Elimination augments|dobj|action action|nmod|END_ENTITY	Elimination of CD4 + T cells in mice bearing an advanced sarcoma augments the antitumor action of interleukin-2 .
8088331	0	CD4	139,142	interleukin-2	53,66	CD4	interleukin-2	920	3558	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	A 150-kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin-specific CD4 + T cells .
8103719	0	CD4	130,133	interleukin-2	14,27	CD4	interleukin-2	920	3558	Gene	Gene	+|compound|START_ENTITY clone|nummod|+ derived|nmod|clone Inhibition|acl|derived Inhibition|nmod|synthesis synthesis|compound|END_ENTITY	Inhibition of interleukin-2 synthesis and interleukin-2_receptor_alpha expression on T cells by a cell-free factor derived from a CD4 + regulatory T cell clone .
8104885	0	CD4	116,119	interleukin-2	16,29	CD4	interleukin-2	24932(Tax:10116)	116562(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY Dissociation|nmod|cells Dissociation|nmod|production production|compound|END_ENTITY	Dissociation of interleukin-2 production from the cell activation in response to the mitogenic lectin in peripheral CD4 + T cells of LEC mutant rats .
8110726	0	CD4	127,130	interleukin-2	95,108	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY inhibits|dobj|functions inhibits|nsubj|END_ENTITY	Strain dependence of interleukin-2-induced graft-versus-host_disease protection : evidence that interleukin-2 inhibits selected CD4 functions .
8500265	0	CD4	121,124	interleukin-2	36,49	CD4	interleukin-2	920	3558	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells number|acl|circulating correlated|nmod|number correlated|nsubjpass|production production|nmod|END_ENTITY	The impaired in vitro production of interleukin-2 in HIV_infection is negatively correlated to the number of circulating CD4 + DR + T cells and is reversed by allowing T cells to rest in culture : arguments for in vivo CD4 + T cell activation .
8814276	0	CD4	151,154	interleukin-2	87,100	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY responses|nmod|cells regulation|nmod|responses END_ENTITY|nmod|regulation	Induction of sensitivity to activation-induced_death in primary CD4 + cells : a role for interleukin-2 in the negative regulation of responses by mature CD4 + T cells .
8814276	0	CD4	64,67	interleukin-2	87,100	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activation-induced_death|nmod|cells sensitivity|nmod|activation-induced_death Induction|nmod|sensitivity Induction|dep|role role|nmod|END_ENTITY	Induction of sensitivity to activation-induced_death in primary CD4 + cells : a role for interleukin-2 in the negative regulation of responses by mature CD4 + T cells .
8844341	0	CD4	97,100	interleukin-2	46,59	CD4	interleukin-2	920	3558	Gene	Gene	number|compound|START_ENTITY patients|nmod|number melatonin|nmod|patients END_ENTITY|nmod|melatonin	Neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin in AIDS patients with CD4 cell number below 200/mm3 : a biological phase-II study .
9054522	0	CD4	86,89	interleukin-2	65,78	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Irradiated NC adenocarcinoma cells transduced with both B7 .1 and interleukin-2 induce CD4 + - mediated rejection of established tumors .
9278942	0	CD4	89,92	interleukin-2	23,36	CD4	interleukin-2	713807(Tax:9544)	708017(Tax:9544)	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|compound|END_ENTITY	Blastogenic responses , interleukin-2 production and interleukin-2 receptor expression on CD4 + and CD8 + lymphocytes in rhesus_monkeys experimentally inoculated with Loa_loa .
9301525	0	CD4	15,18	interleukin-2	37,50	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Enhancement of CD4 + T-cell-dependent interleukin-2 production in vitro by murine alveolar macrophages : the role of leukotriene B4 .
9389737	0	CD4	49,52	interleukin-2	24,37	CD4	interleukin-2	920	3558	Gene	Gene	subsets|nummod|START_ENTITY therapy|nmod|subsets therapy|compound|END_ENTITY	Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV + subjects .
9551948	0	CD4	58,61	interleukin-2	84,97	CD4	interleukin-2	920	3558	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|inhibits inhibits|dobj|secretion secretion|compound|END_ENTITY	CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X -LRB- L -RRB- induction .
9831181	0	CD4	35,38	interleukin-2	130,143	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|absence absence|nmod|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
9831181	0	CD4	35,38	interleukin-2	53,66	CD4	interleukin-2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|mice mice|compound|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
18281483	0	CD4	82,85	interleukin-21	64,78	CD4	interleukin-21	920	59067	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4 + cutaneous_T-cell_lymphoma cells .
21047960	0	CD4	31,34	interleukin-21	15,29	CD4	interleukin-21	12504(Tax:10090)	60505(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY responses|amod|END_ENTITY	HIV-1-specific interleukin-21 + CD4 + T cell responses contribute to durable viral control through the modulation of HIV-specific CD8 + T cell function .
24495300	0	CD4	52,55	interleukin-21	23,37	CD4	interleukin-21	920	59067	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|amod|END_ENTITY	Oestrogen up-regulates interleukin-21 production by CD4 -LRB- + -RRB- T lymphocytes in patients with systemic_lupus_erythematosus .
8835120	0	CD4	101,104	interleukin-3	19,32	CD4	interleukin-3	920	3562	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells END_ENTITY|acl|circulating	Gene expression of interleukin-3 and granulocyte_macrophage_colony-stimulating_factor in circulating CD4 + T cells in acute severe asthma .
10712670	0	CD4	97,100	interleukin-4	133,146	CD4	interleukin-4	920	3565	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes regulated|nsubjpass|expression regulated|nmod|END_ENTITY	CXC_chemokine_receptor_4 expression and stromal cell-derived factor-1alpha-induced chemotaxis in CD4 + T lymphocytes are regulated by interleukin-4 and interleukin-10 .
11141321	0	CD4	50,53	interleukin-4	13,26	CD4	interleukin-4	920	3565	Gene	Gene	CD8|compound|START_ENTITY secretion|nmod|CD8 secretion|compound|END_ENTITY	Decreases in interleukin-4 secretion by invariant CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple_sclerosis .
12067309	0	CD4	64,67	interleukin-4	47,60	CD4	interleukin-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Increased expression of interleukin-13 but not interleukin-4 in CD4 + cells from patients with the hyper-IgE_syndrome .
1349531	0	CD4	23,26	interleukin-4	156,169	CD4	interleukin-4	920	3565	Gene	Gene	cells|compound|START_ENTITY Membranes|nmod|cells alpha|nsubj|Membranes alpha|dep|induce induce|nmod|cells cells|nmod|presence presence|nmod|END_ENTITY	Membranes of activated CD4 + T cells expressing T cell receptor -LRB- TcR -RRB- alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4 .
1378016	0	CD4	0,3	interleukin-4	126,139	CD4	interleukin-4	920	3565	Gene	Gene	cells|nummod|START_ENTITY respond|nsubj|cells respond|nmod|secretion secretion|compound|END_ENTITY	CD4 + suppressor cells of autoimmune encephalomyelitis respond to T_cell_receptor-associated determinants on effector cells by interleukin-4 secretion .
14678204	0	CD4	114,117	interleukin-4	28,41	CD4	interleukin-4	920	3565	Gene	Gene	CD57|compound|START_ENTITY END_ENTITY|nmod|CD57	Intracellular expression of interleukin-4 and interferon-gamma by a Mycobacterium tuberculosis antigen-stimulated CD4 + CD57 + T-cell subpopulation with memory phenotype in tuberculosis patients .
15466391	0	CD4	0,3	interleukin-4	13,26	CD4	interleukin-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	CD45RBHi|compound|START_ENTITY END_ENTITY|nsubj|CD45RBHi	CD4 + CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis .
17164429	0	CD4	36,39	interleukin-4	60,73	CD4	interleukin-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY T|nsubj|regulation T|nmod|END_ENTITY	Distinct regulation of autoreactive CD4 T cell expansion by interleukin-4 under conditions of lymphopenia .
17907151	0	CD4	12,15	interleukin-4	60,73	CD4	interleukin-4	920	3565	Gene	Gene	CD8|compound|START_ENTITY Presence|nmod|CD8 +|nsubj|Presence +|nmod|potential potential|amod|END_ENTITY	Presence of CD4 + CD8 + double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic_sclerosis .
19814808	0	CD4	144,147	interleukin-4	89,102	CD4	interleukin-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY responding|dobj|cells antigen|acl|responding induces|nmod|antigen induces|dobj|expression expression|compound|END_ENTITY	Blood feeding by the Rocky Mountain spotted fever vector , Dermacentor andersoni , induces interleukin-4 expression by cognate antigen responding CD4 + T cells .
22130674	0	CD4	0,3	interleukin-4	47,60	CD4	interleukin-4	920	3565	Gene	Gene	Thp5|compound|START_ENTITY induces|nsubj|Thp5 induces|dobj|production production|compound|END_ENTITY	CD4 + T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4 + T cells to direct T helper 2 cell differentiation .
22130674	0	CD4	75,78	interleukin-4	47,60	CD4	interleukin-4	920	3565	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	CD4 + T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4 + T cells to direct T helper 2 cell differentiation .
23545299	0	CD4	74,77	interleukin-4	45,58	CD4	interleukin-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY induce|dobj|T induce|iobj|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
26798325	0	CD4	34,37	interleukin-4	110,123	CD4	interleukin-4	920	3565	Gene	Gene	cells|compound|START_ENTITY deleterious|nsubj|cells deleterious|advcl|produce produce|dobj|END_ENTITY	Interleukin-17-producing decidual CD4 + T cells are not deleterious for human pregnancy when they also produce interleukin-4 .
7589153	0	CD4	12,15	interleukin-4	32,45	CD4	interleukin-4	920	3565	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|produce produce|dobj|END_ENTITY	Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions .
8566015	0	CD4	84,87	interleukin-4	56,69	CD4	interleukin-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY induce|nmod|T induce|dobj|production production|compound|END_ENTITY	In susceptible mice , Leishmania_major induce very rapid interleukin-4 production by CD4 + T cells which are NK1 .1 - .
8566047	0	CD4	42,45	interleukin-4	59,72	CD4	interleukin-4	920	3565	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells development|nmod|cells cells|amod|END_ENTITY	Default development of cloned human naive CD4 T cells into interleukin-4 - and interleukin-5 - producing effector cells .
8613355	0	CD4	123,126	interleukin-4	21,34	CD4	interleukin-4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ associated|nsubjpass|cells reveals|ccomp|associated reveals|nsubj|immunization immunization|nmod|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8766544	0	CD4	168,171	interleukin-4	124,137	CD4	interleukin-4	920	3565	Gene	Gene	cells|compound|START_ENTITY enhances|nmod|cells enhances|dobj|synthesis synthesis|compound|END_ENTITY	Ligation of TAPA-1 -LRB- CD81 -RRB- or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4 + T cells .
9079802	0	CD4	36,39	interleukin-4	62,75	CD4	interleukin-4	920	3565	Gene	Gene	cells|compound|START_ENTITY cells|nmod|production production|compound|END_ENTITY	Interleukin-7 activates human naive CD4 + cells and primes for interleukin-4 production .
9392311	0	CD4	13,16	interleukin-4	65,78	CD4	interleukin-4	920	3565	Gene	Gene	CD7|compound|START_ENTITY Expansion|nmod|CD7 Expansion|dep|cells cells|appos|subset subset|nmod|production production|compound|END_ENTITY	Expansion of CD4 + CD7 - T cells , a memory subset with preferential interleukin-4 production , after bone marrow transplantation .
11038777	0	CD4	15,18	interleukin-5	47,60	CD4	interleukin-5	920	3567	Gene	Gene	T|compound|START_ENTITY Activation|nmod|T lymphocyte|nsubj|Activation lymphocyte|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Activation of CD4 T lymphocyte and release of interleukin-5 in airway from patients with atopic_asthmatics -RSB- .
16266865	0	CD4	60,63	interleukin-5	43,56	CD4	interleukin-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Interleukin-9 stimulates the production of interleukin-5 in CD4 + T cells .
16780678	0	CD4	131,134	interleukin-5	52,65	CD4	interleukin-5	24932(Tax:10116)	24497(Tax:10116)	Gene	Gene	lymphocytes|compound|START_ENTITY Effects|nmod|lymphocytes Effects|nmod|vector vector|acl|carrying carrying|dobj|antisense antisense|amod|END_ENTITY	-LSB- Effects of recombinant adeno-virus vector carrying interleukin-5 antisense on the expression of interleukin-5 mRNA and protein in CD4 + T lymphocytes of asthmatic rats -RSB- .
16780678	0	CD4	131,134	interleukin-5	97,110	CD4	interleukin-5	24932(Tax:10116)	24497(Tax:10116)	Gene	Gene	lymphocytes|compound|START_ENTITY Effects|nmod|lymphocytes Effects|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effects of recombinant adeno-virus vector carrying interleukin-5 antisense on the expression of interleukin-5 mRNA and protein in CD4 + T lymphocytes of asthmatic rats -RSB- .
18686101	0	CD4	47,50	interleukin-5	8,21	CD4	interleukin-5	920	3567	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Reduced interleukin-5 production by peripheral CD4 + T cells in common variable immunodeficiency patients .
7642218	0	CD4	42,45	interleukin-5	14,27	CD4	interleukin-5	12504(Tax:10090)	16191(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Occurrence of interleukin-5 production by CD4 - CD8 - -LRB- double-negative -RRB- T cells in lungs of both normal and congenitally athymic nude_mice infected with Toxocara_canis .
8095124	0	CD4	0,3	interleukin-5	90,103	CD4	interleukin-5	920	3567	Gene	Gene	activation|nummod|START_ENTITY accompanied|nsubjpass|activation accompanied|nmod|concentrations concentrations|nmod|END_ENTITY	CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5 .
8567949	0	CD4	91,94	interleukin-5	68,81	CD4	interleukin-5	920	3567	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4 + T cells .
9217826	0	CD4	51,54	interleukin-5	79,92	CD4	interleukin-5	920	3567	Gene	Gene	CD7|compound|START_ENTITY CD7|parataxis|expressing expressing|dobj|mRNA mRNA|amod|END_ENTITY	Wells ' _ syndrome : a pathogenic role for circulating CD4 + CD7 - T cells expressing interleukin-5 mRNA .
9563728	0	CD4	111,114	interleukin-5	83,96	CD4	interleukin-5	920	3567	Gene	Gene	cells|compound|START_ENTITY enhance|nmod|cells enhance|dobj|production production|amod|END_ENTITY	Alveolar macrophages from atopic asthmatics , but not atopic nonasthmatics , enhance interleukin-5 production by CD4 + T cells .
12571422	0	CD4	83,86	interleukin-6	134,147	CD4	interleukin-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY transfer|nmod|cells induced|nmod|transfer mice|acl|induced chronic_colitis|nmod|mice model|nmod|chronic_colitis model|dep|insights insights|nmod|role role|nmod|END_ENTITY	A new model of chronic_colitis in SCID mice induced by adoptive transfer of CD62L + CD4 + T cells : insights into the regulatory role of interleukin-6 on apoptosis .
16340466	0	CD4	12,15	interleukin-6	136,149	CD4	interleukin-6	920	3569	Gene	Gene	Cells|compound|START_ENTITY Recovery|nmod|Cells associated|nsubjpass|Recovery associated|nmod|polymorphisms polymorphisms|nmod|genes genes|amod|END_ENTITY	Recovery of CD4 + T Cells in HIV patients with a stable virologic response to antiretroviral therapy is associated with polymorphisms of interleukin-6 and central major histocompatibility complex genes .
1656094	0	CD4	110,113	interleukin-6	82,95	CD4	interleukin-6	920	3569	Gene	Gene	clones|compound|START_ENTITY induce|nmod|clones induce|dobj|production production|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4 + T-cell clones .
24944284	0	CD4	122,125	interleukin-6	82,95	CD4	interleukin-6	12504(Tax:10090)	16193(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4 T cells .
8301219	0	CD4	15,18	interleukin-6	22,35	CD4	interleukin-6	920	3569	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|secretion secretion|amod|END_ENTITY	Involvement of CD4 in interleukin-6 secretion by U937 monocytic cells stimulated with the lectin jacalin .
9090764	0	CD4	37,40	interleukin-6	76,89	CD4	interleukin-6	920	3569	Gene	Gene	CD29|compound|START_ENTITY number|nmod|CD29 Relations|nmod|number +|nsubj|Relations +|dobj|cells cells|nmod|factors factors|amod|END_ENTITY	Relations between absolute number of CD4 + CD29 + memory cells and levels of interleukin-6 , rheumatoid factors , and acute phase proteins in rheumatoid synovial fluid .
10583600	0	CD4	78,81	interleukin-7	18,31	CD4	interleukin-7	920	3574	Gene	Gene	T-cell|compound|START_ENTITY maintenance|nmod|T-cell END_ENTITY|nmod|maintenance	Putative role for interleukin-7 in the maintenance of the recirculating naive CD4 + T-cell pool .
12719571	0	CD4	74,77	interleukin-7	57,70	CD4	interleukin-7	920	3574	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Positive regulation of CXCR4 expression and signaling by interleukin-7 in CD4 + mature thymocytes correlates with their capacity to favor human_immunodeficiency_X4_virus replication .
15331707	0	CD4	65,68	interleukin-7	12,25	CD4	interleukin-7	12504(Tax:10090)	16196(Tax:10090)	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ induces|dobj|proliferation induces|nsubj|END_ENTITY	Recombinant interleukin-7 induces proliferation of naive macaque CD4 + and CD8 + T cells in vivo .
15934068	0	CD4	120,123	interleukin-7	25,38	CD4	interleukin-7	920	3574	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Increased intraarticular interleukin-7 in rheumatoid_arthritis patients stimulates cell contact-dependent activation of CD4 -LRB- + -RRB- T cells and macrophages .
16406844	0	CD4	63,66	interleukin-7	96,109	CD4	interleukin-7	920	3574	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Ex vivo expansion of dendritic-cell-activated antigen-specific CD4 + T cells with anti-CD3 / CD28 , interleukin-7 , and interleukin-15 : potential for adoptive T cell immunotherapy .
21214539	0	CD4	83,86	interleukin-7	138,151	CD4	interleukin-7	920	3574	Gene	Gene	cells|compound|START_ENTITY cells|dep|involvement involvement|nmod|END_ENTITY	Cytomegalovirus_infection induces the accumulation of short-lived , multifunctional CD4 + CD45RA + CD27 + T cells : the potential involvement of interleukin-7 in this process .
25784743	0	CD4	22,25	interleukin-7	46,59	CD4	interleukin-7	920	3574	Gene	Gene	responses|compound|START_ENTITY inhibits|dobj|responses inhibits|nmod|END_ENTITY	Interferon-a inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling .
25784743	0	CD4	22,25	interleukin-7	46,59	CD4	interleukin-7	920	3574	Gene	Gene	responses|compound|START_ENTITY inhibits|dobj|responses inhibits|nmod|END_ENTITY	Interferon-a inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling .
26675348	0	CD4	42,45	interleukin-7	18,31	CD4	interleukin-7	920	3574	Gene	Gene	START_ENTITY|nsubj|Administration Administration|nmod|increases increases|amod|END_ENTITY	Administration of interleukin-7 increases CD4 T cells in idiopathic CD4_lymphocytopenia .
7507711	0	CD4	71,74	interleukin-7	7,20	CD4	interleukin-7	920	3574	Gene	Gene	cells|nummod|START_ENTITY propagate|dobj|cells END_ENTITY|acl|propagate	Use of interleukin-7 , interleukin-2 , and interferon-gamma to propagate CD4 + T cells in culture with maintained antigen specificity .
7871393	0	CD4	76,79	interleukin-7	42,55	CD4	interleukin-7	920	3574	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Differential effects of interleukin-2 and interleukin-7 on the induction of CD4 and CD8 expression by double-negative human thymocytes .
9420139	0	CD4	127,130	interleukin-7	15,28	CD4	interleukin-7	920	3574	Gene	Gene	subset|compound|START_ENTITY role|nmod|subset role|nmod|molecules molecules|amod|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
19616200	0	CD4	11,14	interleukin_17	86,100	CD4	interleukin 17	920	3605	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|Foxp3 Foxp3|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
12200381	0	CD4	126,129	interleukin_2	34,47	CD4	interleukin 2	920	3558	Gene	Gene	subset|nmod|START_ENTITY characterization|nmod|subset effects|dep|characterization effects|nmod|therapy therapy|amod|END_ENTITY	Long-term effects of intermittent interleukin_2 therapy in patients with HIV_infection : characterization of a novel subset of CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- T cells .
15206062	0	CD4	0,3	interleukin_2	45,58	CD4	interleukin 2	920	3558	Gene	Gene	response|compound|START_ENTITY response|nmod|doses doses|nmod|END_ENTITY	CD4 cell response to 3 doses of subcutaneous interleukin_2 : meta-analysis of 3 Vanguard studies .
1531787	0	CD4	0,3	interleukin_2	47,60	CD4	interleukin 2	920	3558	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ modulate|nsubj|cells modulate|dobj|responsiveness responsiveness|amod|END_ENTITY	CD4 + CD45RA + T cells modulate allergen-induced interleukin_2 responsiveness in human lymphocytes .
1534818	0	CD4	8,11	interleukin_2	41,54	CD4	interleukin 2	920	3558	Gene	Gene	molecule|nummod|START_ENTITY molecule|nmod|induction induction|nmod|receptor receptor|amod|END_ENTITY	Role of CD4 molecule in the induction of interleukin_2 and interleukin_2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones .
1608966	0	CD4	0,3	interleukin_2	21,34	CD4	interleukin 2	920	3558	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|responses responses|amod|END_ENTITY	CD4 and CD8 regulate interleukin_2 responses of T cells .
16760795	0	CD4	33,36	interleukin_2	133,146	CD4	interleukin 2	920	3558	Gene	Gene	T-cell|compound|START_ENTITY evaluating|nmod|T-cell study|acl|evaluating count|nsubj|study count|nmod|interruption interruption|nmod|/ /|dep|END_ENTITY	A pilot study evaluating time to CD4 T-cell count < 350 cells/mm -LRB- 3 -RRB- after treatment interruption following antiretroviral therapy + / - interleukin_2 : results of ACTG A5102 .
17274112	0	CD4	0,3	interleukin_2	119,132	CD4	interleukin 2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY promote|nsubj|cells promote|nmod|delivery delivery|nmod|END_ENTITY	CD4 + Th1 cells promote CD8 + Tc1 cell survival , memory response , tumor localization and therapy by targeted delivery of interleukin_2 via acquired pMHC I complexes .
1836455	0	CD4	57,60	interleukin_2	129,142	CD4	interleukin 2	920	3558	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells induced|nsubj|activity induced|nmod|antibody antibody|nmod|END_ENTITY	Bispecific antibody-directed antitumor activity of human CD4 + helper/killer T cells induced by anti-CD3 monoclonal antibody plus interleukin_2 .
1902447	0	CD4	131,134	interleukin_2	68,81	CD4	interleukin 2	920	3558	Gene	Gene	cells|compound|START_ENTITY receptor|nmod|cells receptor|amod|END_ENTITY	Macrophage-T cell interaction is essential for the induction of p75 interleukin_2 -LRB- IL-2 -RRB- _ receptor and IL-2 responsiveness in human CD4 + T cells .
1908085	0	CD4	84,87	interleukin_2	32,45	CD4	interleukin 2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Production of interferon_gamma , interleukin_2 , interleukin_4 , and interleukin_10 by CD4 + lymphocytes in vivo during healing and progressive murine leishmaniasis .
2149068	0	CD4	15,18	interleukin_2	61,74	CD4	interleukin 2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY mature|nsubj|+ mature|ccomp|show show|dobj|responsiveness responsiveness|nmod|END_ENTITY	Neonatal mouse CD4 + mature thymocytes show responsiveness to interleukin_2 and interleukin_7 : growth in vitro of negatively selected V beta 6 - and V beta 11-expressing CD4 + cells from -LRB- C57BL/6 x DBA/2 -RRB- F1 mice .
2315327	0	CD4	91,94	interleukin_2	124,137	CD4	interleukin 2	920	3558	Gene	Gene	lymphocytes|compound|START_ENTITY defects|nmod|lymphocytes produces|dobj|defects produces|advcl|inhibiting inhibiting|dobj|mRNA mRNA|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 produces immune defects in CD4 + T lymphocytes by inhibiting interleukin_2 mRNA .
2511620	0	CD4	65,68	interleukin_2	16,29	CD4	interleukin 2	920	3558	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Mitogen-induced interleukin_2 and gamma interferon production by CD4 + and CD8 + cells of patients with inflammatory arthritides .
2901965	0	CD4	75,78	interleukin_2	13,26	CD4	interleukin 2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	lysis|nmod|START_ENTITY lysis|amod|END_ENTITY	Low doses of interleukin_2 induce bystander cell lysis by antigen-specific CD4 + inflammatory T cell clones in short-term assay .
2961571	0	CD4	114,117	interleukin_2	22,35	CD4	interleukin 2	920	3558	Gene	Gene	cells|compound|START_ENTITY synthesis|nmod|cells synthesis|nsubj|production production|nmod|END_ENTITY	Reduced production of interleukin_2 and interferon-gamma and enhanced helper activity for IgG synthesis by cloned CD4 + T cells from patients with AIDS .
2970968	0	CD4	21,24	interleukin_2	89,102	CD4	interleukin 2	920	3558	Gene	Gene	cells|compound|START_ENTITY subsets|nmod|cells subsets|acl|differing differing|xcomp|produce produce|dobj|END_ENTITY	Two subsets of human CD4 + T helper cells differing in kinetics and capacities to produce interleukin_2 and interferon-gamma can be defined by the Leu-18 and UCHL1 monoclonal antibodies .
3106067	0	CD4	148,151	interleukin_2	105,118	CD4	interleukin 2	920	3558	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin_2 receptor expression in human CD4 and CD8 T cells .
8434390	1	CD4	128,131	interleukin_2	206,219	CD4	interleukin 2	24932(Tax:10116)	116562(Tax:10116)	Gene	Gene	Dependence|nmod|START_ENTITY +|nsubj|Dependence +|nmod|END_ENTITY	V. Dependence of CD4 + suppressor cells on the presence of alloantigen and cytokines , including interleukin_2 .
9670041	0	CD4	0,3	interleukin_2	96,109	CD4	interleukin 2	12504(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|suppress suppress|advcl|inhibiting inhibiting|dobj|production production|amod|END_ENTITY	CD4 + CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin_2 production .
2968871	2	CD4	148,151	interleukin_2_receptor	117,139	CD4	interleukin 2 receptor	920	3559	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased mitogen-induced expression of interleukin_2_receptor by both CD4 and CD8 cell subsets .
10377185	0	CD4	92,95	interleukin_4	42,55	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY abolished|nmod|T abolished|nsubjpass|dominance dominance|amod|END_ENTITY	Cure of progressive murine leishmaniasis : interleukin_4 dominance is abolished by transient CD4 -LRB- + -RRB- T cell depletion and T helper cell type 1-selective cytokine therapy .
10720554	0	CD4	41,44	interleukin_4	24,37	CD4	interleukin 4	920	3565	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Increased production of interleukin_4 by CD4 + and CD8 + T cells from patients with tuberculosis is related to the presence of pulmonary cavities .
10973285	0	CD4	61,64	interleukin_4	20,33	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY alloreactive|dobj|cells alloreactive|nsubj|role role|nmod|END_ENTITY	A critical role for interleukin_4 in activating alloreactive CD4 T cells .
11409116	0	CD4	47,50	interleukin_4	23,36	CD4	interleukin 4	920	3565	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Increased frequency of interleukin_4 producing CD4 + and CD8 + cells in peripheral blood from patients with systemic_sclerosis .
11796615	0	CD4	47,50	interleukin_4	115,128	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	lymphocytes|dep|START_ENTITY lymphocytes|dep|induction induction|nmod|IL-4 IL-4|amod|END_ENTITY	Fas_ligand-expressing B-1a lymphocytes mediate CD4 -LRB- + -RRB- - T-cell apoptosis during schistosomal_infection : induction by interleukin_4 -LRB- IL-4 -RRB- and IL-10 .
1348406	0	CD4	16,19	interleukin_4	125,138	CD4	interleukin 4	920	3565	Gene	Gene	Coexpression|nmod|START_ENTITY Coexpression|dep|involvement involvement|nmod|END_ENTITY	Coexpression of CD4 and CD8 on mitogen-activated peripheral blood T cells from children with asthma : possible involvement of interleukin_4 .
1460418	0	CD4	90,93	interleukin_4	146,159	CD4	interleukin 4	24932(Tax:10116)	287287(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY chains|nmod|cells expression|nmod|chains induce|dobj|expression induce|parataxis|inhibited inhibited|nmod|END_ENTITY	Glucocorticoids induce the expression of CD8_alpha chains on concanavalin A-activated rat CD4 + T cells : induction is inhibited by rat recombinant interleukin_4 .
15579591	0	CD4	158,161	interleukin_4	131,144	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells END_ENTITY|acl|expressed	Contraception in mice immunized with recombinant zona pellucida subunit 3 proteins correlates with Th2 responses and the levels of interleukin_4 expressed by CD4 + cells .
16051465	0	CD4	33,36	interleukin_4	11,24	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Effects of interleukin_4 on CD25 + CD4 + regulatory T cell function .
1908085	0	CD4	84,87	interleukin_4	47,60	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|compound|START_ENTITY interleukin_2|nmod|+ interleukin_2|nummod|END_ENTITY	Production of interferon_gamma , interleukin_2 , interleukin_4 , and interleukin_10 by CD4 + lymphocytes in vivo during healing and progressive murine leishmaniasis .
7902409	0	CD4	61,64	interleukin_4	33,46	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Allergen immunotherapy decreases interleukin_4 production in CD4 + T cells from allergic individuals .
8524877	0	CD4	65,68	interleukin_4	108,121	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY absence|nmod|cells absence|acl:relcl|produce produce|dobj|END_ENTITY	Defective IgE production by SJL mice is linked to the absence of CD4 + , _ NK1 .1 + T cells that promptly produce interleukin_4 .
9096368	0	CD4	18,21	interleukin_4	32,45	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cytokine-autonomous|nmod|cells cytokine-autonomous|nsubj|production production|amod|END_ENTITY	In differentiated CD4 + T cells , interleukin_4 production is cytokine-autonomous , whereas interferon_gamma production is cytokine-dependent .
9380721	0	CD4	48,51	interleukin_4	3,16	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY revealed|nsubjpass|production independent|ccomp|revealed mice|amod|independent END_ENTITY|dep|mice	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9670042	0	CD4	0,3	interleukin_4	115,128	CD4	interleukin 4	920	3565	Gene	Gene	cell|compound|START_ENTITY cytokine|nsubj|cell cytokine|parataxis|instructs instructs|xcomp|express express|dobj|expression expression|amod|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
9670042	0	CD4	92,95	interleukin_4	115,128	CD4	interleukin 4	920	3565	Gene	Gene	cells|compound|START_ENTITY instructs|dobj|cells instructs|xcomp|express express|dobj|expression expression|amod|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
9858515	0	CD4	66,69	interleukin_4	36,49	CD4	interleukin 4	12504(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Genetic regulation of commitment to interleukin_4 production by a CD4 -LRB- + -RRB- T cell-intrinsic mechanism .
9892610	0	CD4	189,192	interleukin_4	109,122	CD4	interleukin 4	24932(Tax:10116)	287287(Tax:10116)	Gene	Gene	CD45RC|compound|START_ENTITY rats|nmod|CD45RC autoimmune_thyroiditis|nmod|rats prevention|nmod|autoimmune_thyroiditis END_ENTITY|nmod|prevention	Regulatory T cells in the control of autoimmunity : the essential role of transforming growth factor beta and interleukin_4 in the prevention of autoimmune_thyroiditis in rats by peripheral CD4 -LRB- + -RRB- CD45RC - cells and CD4 -LRB- + -RRB- CD8 -LRB- - -RRB- thymocytes .
1340208	0	CD4	35,38	interleukin_5	14,27	CD4	interleukin 5	920	3567	Gene	Gene	subset|compound|START_ENTITY END_ENTITY|nmod|subset	Expression of interleukin_5 by the CD4 + CD45R0 + subset of human T cells .
1683650	0	CD4	65,68	lactotransferrin	30,46	CD4	lactotransferrin	12504(Tax:10090)	17002(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Immunostimulatory activity of lactotransferrin and maturation of CD4 - CD8 - murine thymocytes .
12594277	0	CD4	0,3	latency-associated_peptide	31,57	CD4	latency-associated peptide	12504(Tax:10090)	219103(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|dep|cells cells|acl:relcl|express express|ccomp|suppress suppress|nsubj|END_ENTITY	CD4 + CD25 - T cells that express latency-associated_peptide on the surface suppress CD4 + CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism .
12594277	0	CD4	82,85	latency-associated_peptide	31,57	CD4	latency-associated peptide	12504(Tax:10090)	219103(Tax:10090)	Gene	Gene	colitis|nummod|START_ENTITY suppress|dobj|colitis suppress|nsubj|END_ENTITY	CD4 + CD25 - T cells that express latency-associated_peptide on the surface suppress CD4 + CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism .
21426338	0	CD4	88,91	latency-associated_peptide	13,39	CD4	latency-associated peptide	920	7040	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Induction of latency-associated_peptide -LRB- transforming_growth_factor-b -LRB- 1 -RRB- -RRB- expression on CD4 + T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-a production in a transforming growth factor-b-dependent manner .
10190908	0	CD4	105,108	lck	145,148	CD4	lck	920	3932	Gene	Gene	motifs|nmod|START_ENTITY motifs|acl:relcl|thymocytes thymocytes|advcl|limiting limiting|dobj|p56 p56|appos|END_ENTITY	ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs -LRB- ITAMs -RRB- in immature CD4 -LRB- + -RRB- 8 -LRB- + -RRB- thymocytes with limiting p56 -LRB- lck -RRB- .
16424048	0	CD4	25,28	lck	65,68	CD4	lck	920	3932	Gene	Gene	activation|compound|START_ENTITY impairs|dobj|activation impairs|nmod|inhibition inhibition|nmod|END_ENTITY	Prostaglandin_E2 impairs CD4 + T cell activation by inhibition of lck : implications in Hodgkin 's _ lymphoma .
2107088	0	CD4	75,78	lck	125,128	CD4	lck	920	3932	Gene	Gene	interaction|nmod|START_ENTITY nature|nmod|interaction tyrosine|nsubj|nature tyrosine|dobj|END_ENTITY	Structural nature of the interaction between T lymphocyte surface molecule CD4 and the intracellular protein tyrosine kinase lck .
2118992	0	CD4	42,45	lck	88,91	CD4	lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	Cross-linking|nmod|START_ENTITY stimulates|nsubj|Cross-linking stimulates|dobj|phosphorylation phosphorylation|nmod|kinase kinase|amod|END_ENTITY	Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site .
2582490	0	CD4	75,78	lck	4,7	CD4	lck	920	3932	Gene	Gene	glycoprotein|compound|START_ENTITY tail|nmod|glycoprotein tyrosine|nmod|tail tyrosine|nsubj|END_ENTITY	The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain .
7871751	0	CD4	36,39	lck	77,80	CD4	lck	920	3932	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression downregulation|dep|relevance relevance|nmod|domain domain|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
7871751	0	CD4	99,102	lck	77,80	CD4	lck	920	3932	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
8871625	0	CD4	48,51	lck	100,103	CD4	lck	920	3932	Gene	Gene	domain|nmod|START_ENTITY analysis|nmod|domain analysis|dep|overlapping overlapping|nmod|association association|compound|END_ENTITY	Molecular analysis of the cytoplasmic domain of CD4 : overlapping but noncompetitive requirement for lck association and down-regulation by Nef .
9166404	0	CD4	95,98	lck	50,53	CD4	lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	membrane|nmod|START_ENTITY membrane|nsubj|signals signals|nmod|END_ENTITY	Intrinsic signals in the unique domain target p56 -LRB- lck -RRB- to the plasma membrane independently of CD4 .
18270248	0	CD4	38,41	mTOR	150,154	CD4	mTOR	920	21977(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY induction|nmod|Foxp3 +|nsubj|induction +|nmod|administration administration|acl|accompanied accompanied|nmod|blockade blockade|nmod|END_ENTITY	De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR .
20335217	0	CD4	25,28	mTOR	0,4	CD4	mTOR	920	21977(Tax:10090)	Gene	Gene	stimulatory|compound|START_ENTITY shape|dobj|stimulatory shape|nsubj|END_ENTITY	mTOR and GSK-3 shape the CD4 + T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS .
22075384	0	CD4	58,61	mTOR	13,17	CD4	mTOR	12504(Tax:10090)	21977(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis .
22545118	0	CD4	37,40	mTOR	121,125	CD4	mTOR	920	21977(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY reprogramming|nmod|Foxp3 abrogated|nsubjpass|reprogramming abrogated|nmod|inhibition inhibition|compound|END_ENTITY	Inflammation-driven reprogramming of CD4 + Foxp3 + regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo .
22904304	0	CD4	102,105	mTOR	15,19	CD4	mTOR	920	21977(Tax:10090)	Gene	Gene	+|compound|START_ENTITY responses|nummod|+ controlling|dobj|responses signature|acl|controlling defines|dobj|signature defines|nsubj|activation activation|compound|END_ENTITY	Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4 + effector T cell responses .
25500904	0	CD4	24,27	mTOR	73,77	CD4	mTOR	920	21977(Tax:10090)	Gene	Gene	T-cell|compound|START_ENTITY T-cell|acl|activation activation|nmod|modulation modulation|nmod|activity activity|compound|END_ENTITY	Azithromycin suppresses CD4 -LRB- + -RRB- T-cell activation by direct modulation of mTOR activity .
24847056	0	CD4	106,109	mTORC1	60,66	CD4	mTORC1	12504(Tax:10090)	382056(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells signaling|compound|END_ENTITY	Cytosolic branched chain aminotransferase -LRB- BCATc -RRB- regulates mTORC1 signaling and glycolytic metabolism in CD4 + T cells .
24078700	0	CD4	92,95	mammalian_target_of_rapamycin	10,39	CD4	mammalian target of rapamycin	920	2475	Gene	Gene	signaling|compound|START_ENTITY promotes|nmod|signaling promotes|nsubj|END_ENTITY	Increased mammalian_target_of_rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function .
25661834	0	CD4	66,69	miR-146a	48,56	CD4	miR-146a	920	406938	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Mycophenolic_acid upregulates miR-142-3P / 5P and miR-146a in lupus CD4 + T cells .
19777054	0	CD4	30,33	miR-155	0,7	CD4	miR-155	12504(Tax:10090)	387173(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY sensitizes|dobj|cells sensitizes|nsubj|inhibition inhibition|amod|END_ENTITY	miR-155 inhibition sensitizes CD4 + Th cells for TREG mediated suppression .
25760478	0	CD4	27,30	miR-155	16,23	CD4	miR-155	920	406947	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Upregulation of miR-155 in CD4 -LRB- + -RRB- T Cells Promoted Th1 Bias in Patients with Unstable_Angina .
20148420	0	CD4	35,38	miR-17-5p	22,31	CD4	miR-17-5p	920	406952	Gene	Gene	lymphocytes|nummod|START_ENTITY END_ENTITY|nmod|lymphocytes	Altered expression of miR-17-5p in CD4 + lymphocytes of relapsing-remitting multiple_sclerosis patients .
24098447	0	CD4	23,26	miR-21	13,19	CD4	miR-21	920	406991	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Dual role of miR-21 in CD4 + T-cells : activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells .
24098447	0	CD4	23,26	miR-21	56,62	CD4	miR-21	920	406991	Gene	Gene	+|compound|START_ENTITY miR-21|nmod|+ T-cells|amod|miR-21 T-cells|amod|END_ENTITY	Dual role of miR-21 in CD4 + T-cells : activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells .
12534941	0	CD4	16,19	myelin_basic_protein	42,62	CD4	myelin basic protein	24932(Tax:10116)	24547(Tax:10116)	Gene	Gene	responsive|dep|START_ENTITY IL-4|amod|responsive +|nsubj|IL-4 +|xcomp|specific specific|nmod|END_ENTITY	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
1284651	0	CD4	45,48	myelin_basic_protein	50,70	CD4	myelin basic protein	920	4155	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Human CD8 + T cell clone regulates autologous CD4 + myelin_basic_protein specific T cells .
1371525	0	CD4	69,72	myelin_basic_protein	132,152	CD4	myelin basic protein	920	4155	Gene	Gene	specific|compound|START_ENTITY usage|nmod|specific usage|nmod|END_ENTITY	Diversity in fine specificity and T cell receptor usage of the human CD4 + cytotoxic T cell response specific for the immunodominant myelin_basic_protein peptide 87-106 .
17442539	0	CD4	85,88	myelin_basic_protein	36,56	CD4	myelin basic protein	12504(Tax:10090)	17196(Tax:10090)	Gene	Gene	+|compound|START_ENTITY double|nsubj|+ induces|ccomp|double induces|nsubj|Epicutaneous Epicutaneous|acl|immunization immunization|nmod|END_ENTITY	Epicutaneous -LRB- EC -RRB- immunization with myelin_basic_protein -LRB- MBP -RRB- induces TCRalphabeta + CD4 + CD8 + double positive suppressor cells that protect from experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
26526848	0	CD4	20,23	myelin_basic_protein	51,71	CD4	myelin basic protein	920	4155	Gene	Gene	+|compound|START_ENTITY activation|nmod|+ lymphocytes|nsubj|activation lymphocytes|nmod|END_ENTITY	Early activation of CD4 + and CD8 + T lymphocytes by myelin_basic_protein in subjects with MS. BACKGROUND : Multiple_sclerosis is the most common autoimmune_disorder affecting the central nervous system .
7532684	0	CD4	132,135	myelin_basic_protein	55,75	CD4	myelin basic protein	920	4155	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	The T cell response of HLA-DR transgenic_mice to human myelin_basic_protein and other antigens in the presence and absence of human CD4 .
7533179	0	CD4	115,118	myelin_basic_protein	15,35	CD4	myelin basic protein	24932(Tax:10116)	24547(Tax:10116)	Gene	Gene	blockade|nmod|START_ENTITY converted|nmod|blockade agonist|acl:relcl|converted agonist|nsubj|END_ENTITY	Autologous rat myelin_basic_protein is a partial agonist that is converted into a full antagonist upon blockade of CD4 .
7541826	0	CD4	79,82	myelin_basic_protein	31,51	CD4	myelin basic protein	12504(Tax:10090)	17196(Tax:10090)	Gene	Gene	+|nummod|START_ENTITY mediate|nsubj|+ END_ENTITY|parataxis|mediate	Induction of oral tolerance to myelin_basic_protein in CD8-depleted mice : both CD4 + and CD8 + cells mediate active suppression .
7679649	0	CD4	56,59	myelin_basic_protein	34,54	CD4	myelin basic protein	920	4155	Gene	Gene	cells|nummod|START_ENTITY autoimmunity|dep|cells autoimmunity|nmod|END_ENTITY	Human T cell autoimmunity against myelin_basic_protein : CD4 + cells recognizing epitopes of the T_cell_receptor beta chain from a myelin_basic_protein-specific T cell clone .
12616478	0	CD4	0,3	myelin_oligodendrocyte_glycoprotein	25,60	CD4	myelin oligodendrocyte glycoprotein	920	4340	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	CD4 T cell activation by myelin_oligodendrocyte_glycoprotein is suppressed by adult but not cord blood CD25 + T cells .
18209086	0	CD4	62,65	myeloid_differentiation_factor_88	4,37	CD4	myeloid differentiation factor 88	12504(Tax:10090)	17874(Tax:10090)	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|END_ENTITY	The myeloid_differentiation_factor_88 -LRB- MyD88 -RRB- is required for CD4 + T cell effector function in a murine model of inflammatory_bowel_disease .
11396948	0	CD4	103,106	nef	68,71	CD4	nef	920	156110(Tax:11676)	Gene	Gene	downregulation|nmod|START_ENTITY sequences|nmod|downregulation sequences|compound|END_ENTITY	Differential effects of primary human_immunodeficiency_virus_type_1 nef sequences on downregulation of CD4 and MHC class I .
12816953	0	CD4	9,12	nef	49,52	CD4	nef	920	156110(Tax:11676)	Gene	Gene	alleles|nummod|START_ENTITY alleles|compound|END_ENTITY	Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication .
1355346	0	CD4	91,94	nef	119,122	CD4	nef	920	156110(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY altered|nmod|cells altered|xcomp|expressing expressing|dobj|protein protein|compound|END_ENTITY	Activation pathways and human_immunodeficiency_virus_type_1 replication are not altered in CD4 + T cells expressing the nef protein .
19424050	0	CD4	79,82	nef	45,48	CD4	nef	920	6285	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|nsubj|END_ENTITY	HIV escape from natural killer cytotoxicity : nef inhibits NKp44L expression on CD4 + T cells .
2014052	0	CD4	66,69	nef	73,76	CD4	nef	920	6285	Gene	Gene	downregulation|nmod|START_ENTITY Serine|dobj|downregulation Serine|nmod|END_ENTITY	Serine phosphorylation-independent downregulation of cell-surface CD4 by nef .
21165790	0	CD4	0,3	nef	50,53	CD4	nef	920	156110(Tax:11676)	Gene	Gene	class|nsubj|START_ENTITY class|dobj|activities activities|nmod|alleles alleles|compound|END_ENTITY	CD4 and MHC class 1 down-modulation activities of nef alleles from brain - and lymphoid tissue-derived primary HIV-1 isolates .
7903679	0	CD4	113,116	nef	18,21	CD4	nef	920	156110(Tax:11676)	Gene	Gene	lymphocytes|compound|START_ENTITY importance|nmod|lymphocytes importance|nmod|END_ENTITY	The importance of nef in the induction of human_immunodeficiency_virus_type_1 replication from primary quiescent CD4 lymphocytes .
8516299	0	CD4	0,3	nef	23,26	CD4	nef	920	156110(Tax:11676)	Gene	Gene	down-regulation|nummod|START_ENTITY down-regulation|nmod|alleles alleles|compound|END_ENTITY	CD4 down-regulation by nef alleles isolated from human_immunodeficiency_virus_type_1-infected individuals .
9343202	0	CD4	157,160	nef	113,116	CD4	nef	920	156110(Tax:11676)	Gene	Gene	cells|compound|START_ENTITY replication|nmod|cells gene|nmod|replication gene|compound|END_ENTITY	Mutational analysis of human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- accessory genes : requirement of a site in the nef gene for HIV-1 replication in activated CD4 + T cells in vitro and in vivo .
9314355	0	CD4	6,9	nerve_growth_factor	45,64	CD4	nerve growth factor	920	4803	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|produce produce|dobj|END_ENTITY	Human CD4 + T cell clones produce and release nerve_growth_factor and express high-affinity nerve_growth_factor receptors .
14555839	0	CD4	93,96	osteopontin	21,32	CD4	osteopontin	12504(Tax:10090)	20750(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY proliferation|nmod|lymphocytes roles|dep|proliferation roles|nmod|END_ENTITY	The roles of soluble osteopontin using osteopontin-transgenic_mice in vivo : proliferation of CD4 + T lymphocytes and the enhancement of cell-mediated immune responses .
19017937	0	CD4	82,85	osteopontin	10,21	CD4	osteopontin	920	6696	Gene	Gene	cells|nummod|START_ENTITY amplifies|nmod|cells amplifies|nsubj|expression expression|compound|END_ENTITY	Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4 + T cells in experimental_autoimmune_encephalomyelitis and in multiple_sclerosis .
19670379	0	CD4	73,76	osteopontin	48,59	CD4	osteopontin	12504(Tax:10090)	20750(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4 + T Cells in MS. IFN-beta currently serves as one of the major treatments for MS. Its anti-inflammatory mechanism has been reported as involving a shift in cytokine balance from Th1 to Th2 in the T-cell response against elements of the myelin sheath .
9743338	0	CD4	34,37	p120GAP	23,30	CD4	p120GAP	12504(Tax:10090)	5921	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Sam68 association with p120GAP in CD4 + T cells is dependent on CD4 molecule expression .
9743338	0	CD4	63,66	p120GAP	23,30	CD4	p120GAP	12504(Tax:10090)	5921	Gene	Gene	expression|compound|START_ENTITY dependent|nmod|expression dependent|nsubj|association association|nmod|END_ENTITY	Sam68 association with p120GAP in CD4 + T cells is dependent on CD4 molecule expression .
26645604	0	CD4	42,45	p21	74,77	CD4	p21	920	1026	Gene	Gene	Cells|compound|START_ENTITY Replication|nmod|Cells Replication|nmod|END_ENTITY	Atorvastatin Restricts HIV Replication in CD4 + T Cells by Upregulation of p21 .
26755399	0	CD4	66,69	p21	59,62	CD4	p21	920	1026	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	HIV-1 Infection Dysregulates Cell Cycle Regulatory Protein p21 in CD4 + T Cells through miR-20a and miR-106b Regulation .
7589131	0	CD4	41,44	p21	114,117	CD4	p21	12504(Tax:10090)	12575(Tax:10090)	Gene	Gene	T|compound|START_ENTITY activation|nmod|T lymphocytes|nsubj|activation lymphocytes|nmod|cells cells|acl|bearing bearing|dobj|epitopes epitopes|nmod|K-ras K-ras|nummod|END_ENTITY	Peptide-specific activation of cytolytic CD4 + T lymphocytes against tumor cells bearing mutated epitopes of K-ras p21 .
16875837	0	CD4	42,45	p24	34,37	CD4	p24	920	10959	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	The antigenic determinants on HIV p24 for CD4 + T cell inhibiting antibodies as determined by limited proteolysis , chemical modification , and mass spectrometry .
11958687	0	CD4	64,67	p53	18,21	CD4	p53	920	7157	Gene	Gene	T|compound|START_ENTITY apoptosis|nmod|T apoptosis|compound|END_ENTITY	Ability to induce p53 and caspase-mediated apoptosis in primary CD4 + T cells is variable among primary isolates of human_immunodeficiency_virus_type_1 .
17875988	0	CD4	21,24	p53	82,85	CD4	p53	12504(Tax:10090)	22060(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|acl|+ +|nmod|cells cells|nmod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	CD4	61,64	p53	82,85	CD4	p53	12504(Tax:10090)	22060(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
18245492	0	CD4	37,40	p53	72,75	CD4	p53	12504(Tax:10090)	22060(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nmod|antigen antigen|compound|END_ENTITY	Self-tolerance does not restrict the CD4 + T-helper response against the p53 tumor antigen .
19184003	0	CD4	0,3	p53	63,66	CD4	p53	920	7157	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|xcomp|HLA-DP5-restricted HLA-DP5-restricted|dobj|peptides peptides|compound|END_ENTITY	CD4 + T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head_and_neck_cancer .
21858191	0	CD4	65,68	p53	108,111	CD4	p53	920	7157	Gene	Gene	+|compound|START_ENTITY responses|dep|+ responses|nmod|END_ENTITY	Split T cell tolerance against a self/tumor antigen : spontaneous CD4 + but not CD8 + T cell responses against p53 in cancer patients and healthy donors .
24792911	0	CD4	101,104	p53	35,38	CD4	p53	920	7157	Gene	Gene	T|compound|START_ENTITY critical|nmod|T responses|amod|critical responses|nsubj|Downmodulation Downmodulation|nmod|END_ENTITY	Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4 -LRB- + -RRB- T cell responses .
7909159	0	CD4	41,44	p53	15,18	CD4	p53	12504(Tax:10090)	22060(Tax:10090)	Gene	Gene	+|compound|START_ENTITY recognized|nmod|+ recognized|nsubj|product product|compound|END_ENTITY	A mouse mutant p53 product recognized by CD4 + and CD8 + T cells .
8666950	0	CD4	31,34	p53	0,3	CD4	p53	12504(Tax:10090)	22060(Tax:10090)	Gene	Gene	stage|compound|START_ENTITY prevents|nmod|stage prevents|nsubj|END_ENTITY	p53 prevents maturation to the CD4 + CD8 + stage of thymocyte differentiation in the absence of T cell receptor rearrangement .
9485210	0	CD4	44,47	p53	69,72	CD4	p53	920	7157	Gene	Gene	specific|compound|START_ENTITY specific|nmod|peptides peptides|compound|END_ENTITY	Evidence that HLA class II-restricted human CD4 + T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms .
9485210	0	CD4	44,47	p53	98,101	CD4	p53	920	7157	Gene	Gene	specific|compound|START_ENTITY HLA|dobj|specific Evidence|acl:relcl|HLA respond|nsubj|Evidence respond|nmod|proteins proteins|compound|END_ENTITY	Evidence that HLA class II-restricted human CD4 + T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms .
9830036	0	CD4	45,48	p56	33,36	CD4	p56	920	8999	Gene	Gene	lck|nmod|START_ENTITY lck|amod|END_ENTITY	Zinc is essential for binding of p56 -LRB- lck -RRB- to CD4 and CD8alpha .
10744646	0	CD4	75,78	p56Lck	10,16	CD4	p56Lck	920	3932	Gene	Gene	lymphocytopenia|compound|START_ENTITY patient|nmod|lymphocytopenia Defective|nmod|patient Defective|dobj|activity activity|amod|END_ENTITY	Defective p56Lck activity in T cells from an adult patient with idiopathic CD4 + lymphocytopenia .
10843386	0	CD4	100,103	p56Lck	26,32	CD4	p56Lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	thymocytes|compound|START_ENTITY differentiation|nmod|thymocytes reveals|nmod|differentiation reveals|nsubj|expression expression|nmod|transgene transgene|amod|END_ENTITY	Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes .
11854499	0	CD4	15,18	p56Lck	0,6	CD4	p56Lck	920	3932	Gene	Gene	START_ENTITY|nsubj|anchors anchors|amod|END_ENTITY	p56Lck anchors CD4 to distinct microdomains on microvilli .
10383941	0	CD4	64,67	p56lck	23,29	CD4	p56lck	920	3932	Gene	Gene	involves|nmod|START_ENTITY involves|nsubj|CD44 CD44|acl|signaling signaling|nmod|END_ENTITY	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
10383941	0	CD4	77,80	p56lck	23,29	CD4	p56lck	920	3932	Gene	Gene	cells|compound|START_ENTITY CD4|nmod|cells involves|nmod|CD4 involves|nsubj|CD44 CD44|acl|signaling signaling|nmod|END_ENTITY	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
11086073	0	CD4	63,66	p56lck	86,92	CD4	p56lck	920	3932	Gene	Gene	mediated|nmod|START_ENTITY Desensitization|acl|mediated independent|nsubj|Desensitization independent|nmod|activity activity|amod|END_ENTITY	Desensitization of CXC_chemokine_receptor_4 , mediated by IL-16 / CD4 , is independent of p56lck enzymatic activity .
11160274	0	CD4	44,47	p56lck	10,16	CD4	p56lck	920	3932	Gene	Gene	maturation|nmod|START_ENTITY directs|dobj|maturation directs|nsubj|END_ENTITY	Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes .
11694532	0	CD4	47,50	p56lck	102,108	CD4	p56lck	920	3932	Gene	Gene	isoforms|nmod|START_ENTITY association|nmod|isoforms regulates|nsubj|association regulates|dobj|actions actions|nmod|pools pools|nmod|kinase kinase|amod|END_ENTITY	Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T_cell_antigen_receptor signal transduction .
1280163	0	CD4	100,103	p56lck	47,53	CD4	p56lck	920	3932	Gene	Gene	internalization|nmod|START_ENTITY regulates|dobj|internalization regulates|nsubj|lymphocyte-specific_protein_tyrosine_kinase lymphocyte-specific_protein_tyrosine_kinase|appos|END_ENTITY	A lymphocyte-specific_protein_tyrosine_kinase , p56lck , regulates the PMA-induced internalization of CD4 .
1373141	0	CD4	44,47	p56lck	28,34	CD4	p56lck	920	3932	Gene	Gene	endocytosis|nummod|START_ENTITY inhibits|dobj|endocytosis inhibits|nsubj|END_ENTITY	The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits .
1373141	0	CD4	83,86	p56lck	28,34	CD4	p56lck	920	3932	Gene	Gene	entry|nmod|START_ENTITY preventing|dobj|entry inhibits|advcl|preventing inhibits|nsubj|END_ENTITY	The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits .
1532002	0	CD4	24,27	p56lck	0,6	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation .
1532002	0	CD4	68,71	p56lck	0,6	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY required|nmod|interaction required|nsubjpass|association association|amod|END_ENTITY	p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation .
1535787	0	CD4	66,69	p56lck	96,102	CD4	p56lck	920	3932	Gene	Gene	glycoprotein|nmod|START_ENTITY human_immunodeficiency_virus|acl|glycoprotein Interaction|nmod|human_immunodeficiency_virus increases|nsubj|Interaction increases|dobj|autophosphorylation autophosphorylation|amod|END_ENTITY	Interaction of human_immunodeficiency_virus glycoprotein 160 with CD4 in Jurkat cells increases p56lck autophosphorylation and kinase activity .
1900242	0	CD4	6,9	p56lck	91,97	CD4	p56lck	920	3932	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|kinase kinase|nmod|END_ENTITY	Avian CD4 and CD8 interact with a cellular tyrosine protein kinase homologous to mammalian p56lck .
2040625	0	CD4	120,123	p56lck	108,114	CD4	p56lck	920	3932	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|dobj|END_ENTITY	Effect of human_immunodeficiency_virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes .
2107025	0	CD4	98,101	p56lck	63,69	CD4	p56lck	920	3932	Gene	Gene	domains|nmod|START_ENTITY END_ENTITY|nmod|domains	Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs .
2109184	0	CD4	54,57	p56lck	118,124	CD4	p56lck	920	3932	Gene	Gene	domains|nmod|START_ENTITY sequences|nmod|domains mediate|nsubj|sequences mediate|xcomp|binding binding|nmod|domain domain|nmod|kinase kinase|amod|END_ENTITY	Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase .
2141630	0	CD4	23,26	p56lck	84,90	CD4	p56lck	920	3932	Gene	Gene	CD45|nmod|START_ENTITY alters|nsubj|CD45 alters|dobj|activity activity|nmod|END_ENTITY	Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck .
2250907	0	CD4	4,7	p56lck	43,49	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	START_ENTITY|acl|associated associated|dobj|END_ENTITY	The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation .
2369920	0	CD4	26,29	p56lck	118,124	CD4	p56lck	920	3932	Gene	Gene	domain|nmod|START_ENTITY required|nsubjpass|domain required|nmod|END_ENTITY	The cytoplasmic domain of CD4 is required for stable association with the lymphocyte-specific tyrosine protein kinase p56lck .
2470098	0	CD4	4,7	p56lck	67,73	CD4	p56lck	920	3932	Gene	Gene	antigens|compound|START_ENTITY coupled|nsubjpass|antigens coupled|nmod|kinase kinase|appos|END_ENTITY	The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase -LRB- p56lck -RRB- that phosphorylates the CD3 complex .
2787934	0	CD4	54,57	p56lck	77,83	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	dissociation|nmod|START_ENTITY induce|dobj|dissociation induce|nmod|END_ENTITY	Activators of protein kinase C induce dissociation of CD4 , but not CD8 , from p56lck .
3262426	0	CD4	4,7	p56lck	106,112	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck .
7522245	0	CD4	18,21	p56lck	30,36	CD4	p56lck	920	3932	Gene	Gene	ligation|nmod|START_ENTITY induces|nsubj|ligation induces|dobj|activation activation|amod|END_ENTITY	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation .
7680610	0	CD4	105,108	p56lck	89,95	CD4	p56lck	920	3932	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	Human_immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes .
7737294	0	CD4	71,74	p56lck	42,48	CD4	p56lck	920	3932	Gene	Gene	kinases|nmod|START_ENTITY kinases|dobj|END_ENTITY	Interactions between the tyrosine kinases p56lck , p59fyn and p50csk in CD4 signaling in T cells .
7902564	0	CD4	89,92	p56lck	125,131	CD4	p56lck	920	3932	Gene	Gene	overexpression|nmod|START_ENTITY reduces|nsubj|overexpression reduces|dobj|ability ability|dep|activate activate|dobj|kinase kinase|amod|END_ENTITY	Decreased signaling competence as a result of receptor overexpression : overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4 + CD8 + thymocytes .
7964457	0	CD4	71,74	p56lck	28,34	CD4	p56lck	920	3932	Gene	Gene	proteins|compound|START_ENTITY mediated|nmod|proteins adhesion|acl|mediated regulates|dobj|adhesion regulates|nsubj|END_ENTITY	The protein tyrosine kinase p56lck regulates cell adhesion mediated by CD4 and major histocompatibility complex class II proteins .
8095557	0	CD4	0,3	p56lck	4,10	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	START_ENTITY|dep|association association|amod|END_ENTITY	CD4 : p56lck association studied in vivo using antibody-induced capping and double indirect immunofluorescence microscopy .
8195720	0	CD4	81,84	p56lck	85,91	CD4	p56lck	920	3932	Gene	Gene	association|compound|START_ENTITY association|amod|END_ENTITY	CD4-mediated enhancement or inhibition of T cell activation does not require the CD4 : p56lck association .
8228817	0	CD4	136,139	p56lck	76,82	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY thymocytes|parataxis|signaling thymocytes|nmod|kinase kinase|amod|END_ENTITY	Regulation of T cell receptor expression in immature CD4 + CD8 + thymocytes by p56lck tyrosine kinase : basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules .
8228817	0	CD4	53,56	p56lck	76,82	CD4	p56lck	12504(Tax:10090)	16818(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ Regulation|nmod|expression thymocytes|nsubj|Regulation thymocytes|nmod|kinase kinase|amod|END_ENTITY	Regulation of T cell receptor expression in immature CD4 + CD8 + thymocytes by p56lck tyrosine kinase : basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules .
8376930	0	CD4	40,43	p56lck	95,101	CD4	p56lck	920	3932	Gene	Gene	downregulation|nmod|START_ENTITY process|nsubj|downregulation process|acl|involving involving|dobj|dissociation dissociation|nmod|END_ENTITY	Phorbol_ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck , increased association with clathrin-coated pits , and altered endosomal sorting .
8391060	0	CD4	105,108	p56lck	28,34	CD4	p56lck	920	3932	Gene	Gene	coreceptors|compound|START_ENTITY interaction|nmod|coreceptors -RSB-|amod|interaction development|nmod|-RSB- regulates|dobj|development regulates|nsubj|END_ENTITY	The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors -LSB- corrected -RSB- .
8551242	0	CD4	102,105	p56lck	111,117	CD4	p56lck	920	3932	Gene	Gene	interaction|nmod|START_ENTITY accelerated|nmod|interaction accelerated|nmod|END_ENTITY	HIV-induced apoptosis requires the CD4_receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck .
8630734	0	CD4	39,42	p56lck	128,134	CD4	p56lck	920	3932	Gene	Gene	thymocytes|compound|START_ENTITY impaired|nmod|thymocytes impaired|nmod|consequence consequence|acl:relcl|diminish diminish|dobj|END_ENTITY	TCR activation of ZAP70 is impaired in CD4 + CD8 + thymocytes as a consequence of intrathymic interactions that diminish available p56lck .
9317140	0	CD4	51,54	p56lck	101,107	CD4	p56lck	920	3932	Gene	Gene	antigen|nummod|START_ENTITY down-regulation|nmod|antigen induces|dobj|down-regulation induces|advcl|affecting affecting|dobj|levels levels|amod|END_ENTITY	Human_herpesvirus_7 induces the down-regulation of CD4 antigen in lymphoid T cells without affecting p56lck levels .
9842906	0	CD4	42,45	p56lck	8,14	CD4	p56lck	920	3932	Gene	Gene	endocytosis|nummod|START_ENTITY correlates|nmod|endocytosis correlates|nsubj|Lack Lack|nmod|expression expression|amod|END_ENTITY	Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells .
15493262	0	CD4	76,79	p80	95,98	CD4	p80	920	8161	Gene	Gene	CDw29|compound|START_ENTITY CDw29|dep|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
25215080	0	CD4	65,68	pituitary_adenylate_cyclase_activating_polypeptide	11,61	CD4	pituitary adenylate cyclase activating polypeptide	24932(Tax:10116)	24166(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pituitary_adenylate_cyclase_activating_polypeptide on CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T cell levels after traumatic_brain_injury in a rat model .
18462346	0	CD4	58,61	prion_protein	13,26	CD4	prion protein	12504(Tax:10090)	19122(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
20382886	0	CD4	54,57	programmed_death-1	107,125	CD4	programmed death-1	12504(Tax:10090)	18566(Tax:10090)	Gene	Gene	+|compound|START_ENTITY function|nmod|+ augment|iobj|function augment|parataxis|involvement involvement|nmod|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20713771	0	CD4	43,46	programmed_death-1	10,28	CD4	programmed death-1	920	5133	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Increased programmed_death-1 expression on CD4 + T cells in cutaneous_T-cell_lymphoma : implications for immune suppression .
9402849	0	CD4	121,124	prolactin	61,70	CD4	prolactin	920	5617	Gene	Gene	blood|compound|START_ENTITY isoforms|nmod|blood expression|nmod|isoforms correlate|nmod|expression correlate|compound|END_ENTITY	Serum levels of interleukin-1_beta , luteinizing hormone , and prolactin correlate with the expression of CD45 isoforms on CD4 + peripheral blood T lymphocytes in healthy women .
14770085	0	CD4	0,3	prostate_specific_antigen	40,65	CD4	prostate specific antigen	920	354	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	CD4 and CD8 T-lymphocyte recognition of prostate_specific_antigen in granulomatous_prostatitis .
2295841	0	CD4	31,34	rCD4	36,40	CD4	rCD4	24932(Tax:10116)	24932(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of recombinant soluble CD4 -LRB- rCD4 -RRB- on HIV-1_infection of monocyte/macrophages .
16315640	0	CD4	0,3	rHSP60	35,41	CD4	rHSP60	920	63868(Tax:10116)	Gene	Gene	T|nsubj|START_ENTITY T|nmod|END_ENTITY	CD4 and CD8 T cell response to the rHSP60 from Klebsiella_pneumoniae in peripheral blood mononuclear cells from patients with ankylosing_spondylitis .
8573611	0	CD4	31,34	rIL-2	16,21	CD4	rIL-2	920	116562(Tax:10116)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Transduction of rIL-2 expanded CD4 + and CD8 + ovarian TIL-derived T cell lines with the G1Na -LRB- neor -RRB- replication-deficient retroviral vector .
15535835	0	CD4	118,121	suppressor_of_cytokine_signaling_1	80,114	CD4	suppressor of cytokine signaling 1	920	8651	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor_of_cytokine_signaling_1 in CD4 + T cells from patients with rheumatoid_arthritis .
10666215	0	CD4	35,38	tax	9,12	CD4	tax	920	1491938(Tax:11908)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Abundant tax protein expression in CD4 + T cells infected with human_T-cell_lymphotropic_virus_type_I _ -LRB- HTLV-I -RRB- is prevented by cytotoxic T lymphocytes .
16416233	0	CD4	135,138	transforming_growth_factor-beta	42,73	CD4	transforming growth factor-beta	920	7040	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Flow cytometric analysis of expression of transforming_growth_factor-beta and glucocorticoid-induced_tumor_necrosis_factor_receptor on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells of patients with inflammatory_bowel_disease .
18473105	0	CD4	64,67	transforming_growth_factor-beta1	28,60	CD4	transforming growth factor-beta1	920	7040	Gene	Gene	CD25|compound|START_ENTITY END_ENTITY|nmod|CD25	Expression of intracellular transforming_growth_factor-beta1 in CD4 + CD25 + cells in patients with systemic_lupus_erythematosus .
7912547	0	CD4	101,104	transforming_growth_factor-beta_1	23,56	CD4	transforming growth factor-beta 1	920	7040	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	Differential effect of transforming_growth_factor-beta_1 on the activation of human naive and memory CD4 + T lymphocytes .
8642767	0	CD4	181,184	transforming_growth_factor-beta_1	27,60	CD4	transforming growth factor-beta 1	920	7040	Gene	Gene	CD3|dep|START_ENTITY level|appos|CD3 level|amod|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
8675229	0	CD4	99,102	transforming_growth_factor-beta_1	29,62	CD4	transforming growth factor-beta 1	920	7040	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Growth regulatory effects of transforming_growth_factor-beta_1 and interleukin-2 on IL-2 dependent CD4 + T lymphoblastoid cell line .
10438843	0	CD4	131,134	tumor_necrosis_factor	184,205	CD4	tumor necrosis factor	920	7124	Gene	Gene	CD8|compound|START_ENTITY human_immunodeficiency_virus|nmod|CD8 thymocytes|amod|human_immunodeficiency_virus thymocytes|dep|role role|nmod|END_ENTITY	Thymocyte-thymic epithelial cell interaction leads to high-level replication of human_immunodeficiency_virus exclusively in mature CD4 -LRB- + -RRB- CD8 -LRB- - -RRB- CD3 -LRB- + -RRB- thymocytes : a critical role for tumor_necrosis_factor and interleukin-7 .
10562322	0	CD4	148,151	tumor_necrosis_factor	22,43	CD4	tumor necrosis factor	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	CD45RB|compound|START_ENTITY transfer|nmod|CD45RB mice|nmod|transfer T|nsubj|mice gene|acl:relcl|T required|nmod|gene required|nsubjpass|END_ENTITY	Nonlymphocyte-derived tumor_necrosis_factor is required for induction of colitis in recombination activating gene -LRB- RAG -RRB- 2 -LRB- - / - -RRB- mice upon transfer of CD4 -LRB- + -RRB- CD45RB -LRB- hi -RRB- T cells .
11037976	0	CD4	142,145	tumor_necrosis_factor	8,29	CD4	tumor necrosis factor	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY infection|nmod|mice bacillus|dobj|infection prevents|ccomp|bacillus prevents|nsubj|END_ENTITY	A novel tumor_necrosis_factor -LRB- TNF -RRB- mimetic peptide prevents recrudescence of Mycobacterium_bovis bacillus Calmette-Guerin -LRB- BCG -RRB- infection in CD4 + T cell-depleted mice .
23494522	0	CD4	52,55	tumor_necrosis_factor	112,133	CD4	tumor necrosis factor	920	7124	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells enables|nsubj|expression enables|xcomp|follow follow|dobj|gradients gradients|compound|END_ENTITY	Tumor_necrosis_factor receptor type I expression of CD4 + T cells in rheumatoid_arthritis enables them to follow tumor_necrosis_factor gradients into the rheumatoid synovium .
24339053	0	CD4	140,143	tumor_necrosis_factor	18,39	CD4	tumor necrosis factor	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	+|compound|START_ENTITY pulmonary_fibrosis|nmod|+ inhibition|nmod|pulmonary_fibrosis contributes|xcomp|inhibition END_ENTITY|ccomp|contributes	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
11399015	0	CD4	181,184	tumor_necrosis_factor_alpha	86,113	CD4	tumor necrosis factor alpha	920	7124	Gene	Gene	T-cell|compound|START_ENTITY patients|nmod|T-cell predictors|nmod|patients END_ENTITY|nmod|predictors	Usefulness of route of transmission , absolute CD8 + T-cell counts , and levels of serum tumor_necrosis_factor_alpha as predictors of survival_of_HIV-1-infected patients with very low CD4 + T-cell counts .
17198884	0	CD4	6,9	tumor_necrosis_factor_alpha	32,59	CD4	tumor necrosis factor alpha	12504(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Donor CD4 + T-cell production of tumor_necrosis_factor_alpha significantly contributes to the early proinflammatory events of graft-versus-host_disease .
18512781	0	CD4	26,29	tumor_necrosis_factor_alpha	81,108	CD4	tumor necrosis factor alpha	920	7124	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells discriminated|nsubjpass|activity discriminated|nmod|END_ENTITY	Suppressor activity among CD4 + , CD25 + + T cells is discriminated by membrane-bound tumor_necrosis_factor_alpha .
21482826	0	CD4	148,151	tumor_necrosis_factor_alpha	171,198	CD4	tumor necrosis factor alpha	920	7124	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|xcomp|affecting affecting|dobj|END_ENTITY	HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3 , syndecan-2 , and syndecan-4 proteoglycans expressed on human activated CD4 + T cells affecting tumor_necrosis_factor_alpha and interleukin_2 production .
9616162	0	CD4	233,236	tumor_necrosis_factor_alpha	12,39	CD4	tumor necrosis factor alpha	920	7124	Gene	Gene	cells|compound|START_ENTITY presenting|nmod|cells function|advcl|presenting function|nsubj|role role|nmod|END_ENTITY	The role of tumor_necrosis_factor_alpha in modulating the quantity of peripheral blood-derived , cytokine-driven human dendritic cells and its role in enhancing the quality of dendritic cell function in presenting soluble antigens to CD4 + T cells in vitro .
21631498	0	CD4	99,102	tumour_necrosis_factor_receptor_type_2	46,84	CD4	tumour necrosis factor receptor type 2	920	7133	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The phenotypic and functional consequences of tumour_necrosis_factor_receptor_type_2 expression on CD4 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
23160220	0	CD4	49,52	tyrosine_hydroxylase	10,30	CD4	tyrosine hydroxylase	12504(Tax:10090)	21823(Tax:10090)	Gene	Gene	T|compound|START_ENTITY silencing|nmod|T silencing|amod|END_ENTITY	Effect of tyrosine_hydroxylase gene silencing in CD4 + T lymphocytes on differentiation and function of helper T cells .
23940951	0	CD4	50,53	tyrosine_hydroxylase	26,46	CD4	tyrosine hydroxylase	12504(Tax:10090)	21823(Tax:10090)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	-LSB- Changes in expression of tyrosine_hydroxylase by CD4 + T lymphocytes in lymphoid tissues of DBA/1 mice with collagen-induced_arthritis -RSB- .
18534815	0	CD4	115,118	vasoactive_intestinal_peptide_receptor-1	37,77	CD4	vasoactive intestinal peptide receptor-1	12504(Tax:10090)	22354(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	TCR signaling and environment affect vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- expression in primary mouse CD4 T cells .
18555660	0	CD4	125,128	vasoactive_intestinal_peptide_receptor-1	58,98	CD4	vasoactive intestinal peptide receptor-1	12504(Tax:10090)	22354(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY VPAC-1|nmod|cells VPAC-1|amod|END_ENTITY	Stimulatory and suppressive signal transduction regulates vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- in primary mouse CD4 T cells .
19729043	0	CD4	159,162	vasoactive_intestinal_peptide_receptor-1	59,99	CD4	vasoactive intestinal peptide receptor-1	12504(Tax:10090)	22354(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY position|nmod|cells suggests|dobj|position suggests|nsubj|landscape landscape|nmod|promoter promoter|amod|END_ENTITY	A transcriptionally permissive epigenetic landscape at the vasoactive_intestinal_peptide_receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T cells .
7759875	0	CD4-CD8	48,55	IL-2	27,31	CD4-CD8	IL-2	920;925	3558	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Abnormal regulation of the IL-2 promoter in lpr CD4-CD8 - T lymphocytes results in constitutive expression of a novel nuclear factor of activated T cells-binding factor .
24189063	0	CD40	124,128	ADAM17	112,118	CD40	ADAM17	958	6868	Gene	Gene	manner|compound|START_ENTITY END_ENTITY|nmod|manner	CD154 is released from T-cells by a disintegrin and metalloproteinase domain-containing protein 10 -LRB- ADAM10 -RRB- and ADAM17 in a CD40 protein-dependent manner .
23429328	0	CD40	8,12	AKT	20,23	CD40	AKT	958	207	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
22241832	0	CD40	12,16	APCs	30,34	CD40	APCs	21939(Tax:10090)	20219(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Synergistic CD40 signaling on APCs and CD8 T cells drives efficient CD8 response and memory differentiation .
22786446	0	CD40	28,32	Apolipoprotein_A-I	0,18	CD40	Apolipoprotein A-I	958	335	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Apolipoprotein_A-I inhibits CD40 proinflammatory signaling via ATP-binding_cassette_transporter_A1-mediated modulation of lipid raft in macrophages .
11745400	0	CD40	17,21	B_cell_antigen_receptor	48,71	CD40	B cell antigen receptor	958	613	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	The influence of CD40 on the association of the B_cell_antigen_receptor with lipid rafts in mature and immature cells .
10452982	0	CD40	20,24	CD154	14,19	CD40	CD154	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY Disruption|dep|generation Disruption|nmod|END_ENTITY	Disruption of CD154 : CD40 blocks generation of allograft immunity without affecting APC activation .
10491009	0	CD40	19,23	CD154	32,37	CD40	CD154	958	959	Gene	Gene	Hyperexpression|nmod|START_ENTITY ligand|nsubj|Hyperexpression ligand|dobj|END_ENTITY	Hyperexpression of CD40 ligand -LRB- CD154 -RRB- in inflammatory_bowel_disease and its contribution to pathogenic cytokine production .
10510356	0	CD40	57,61	CD154	70,75	CD40	CD154	958	959	Gene	Gene	associated|nmod|START_ENTITY proteins|acl|associated Characterization|nmod|proteins ligand|nsubj|Characterization ligand|dobj|turnover turnover|appos|END_ENTITY	Characterization of RNA binding proteins associated with CD40 ligand -LRB- CD154 -RRB- mRNA turnover in human T lymphocytes .
10513352	0	CD40	16,20	CD154	9,14	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY synthesis|parataxis|ligand synthesis|nsubj|END_ENTITY	Elevated CD154 -LRB- CD40 ligand -RRB- synthesis in T-cells from allergic patients after nonspecific stimulation in vitro .
10651941	0	CD40	121,125	CD154	148,153	CD40	CD154	958	959	Gene	Gene	ability|nmod|START_ENTITY interferes|nmod|ability interferes|xcomp|block block|dobj|END_ENTITY	A polymorphic CD40 ligand -LRB- CD154 -RRB- molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154 : CD40 interactions .
10651941	0	CD40	14,18	CD154	27,32	CD40	CD154	958	959	Gene	Gene	polymorphic|dep|START_ENTITY molecule|amod|polymorphic molecule|appos|END_ENTITY	A polymorphic CD40 ligand -LRB- CD154 -RRB- molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154 : CD40 interactions .
10651941	0	CD40	154,158	CD154	148,153	CD40	CD154	958	959	Gene	Gene	interactions|nummod|START_ENTITY END_ENTITY|dep|interactions	A polymorphic CD40 ligand -LRB- CD154 -RRB- molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154 : CD40 interactions .
10684857	0	CD40	0,4	CD154	13,18	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|triggers triggers|nsubj|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- triggers a short-term CD4 -LRB- + -RRB- T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis .
10700427	0	CD40	24,28	CD154	37,42	CD40	CD154	958	959	Gene	Gene	expression|nmod|START_ENTITY ligand|nsubj|expression ligand|dobj|END_ENTITY	Increased expression of CD40 ligand -LRB- CD154 -RRB- on CD4 + T cells as a marker of disease activity in rheumatoid_arthritis .
10755553	0	CD40	45,49	CD154	82,87	CD40	CD154	397395(Tax:9823)	959	Gene	Gene	START_ENTITY|nmod|conserved conserved|nmod|END_ENTITY	High sequence homology between human and pig CD40 with conserved binding to human CD154 .
10856699	0	CD40	7,11	CD154	0,5	CD40	CD154	958	959	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|appos|ligand	CD154 -LRB- CD40 ligand -RRB- .
10940889	0	CD40	110,114	CD154	123,128	CD40	CD154	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induce|nmod|induction induce|dep|expression expression|appos|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
11044648	0	CD40	23,27	CD154	45,50	CD40	CD154	958	959	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abundant expression of CD40 and CD40-ligand -LRB- CD154 -RRB- in paediatric Langerhans_cell_histiocytosis_lesions .
11168635	0	CD40	23,27	CD154	89,94	CD40	CD154	958	959	Gene	Gene	antibodies|nummod|START_ENTITY activity|nmod|antibodies correlates|nsubj|activity correlates|nmod|position position|nmod|relative relative|nmod|END_ENTITY	Functional activity of CD40 antibodies correlates to the position of binding relative to CD154 .
11187868	0	CD40	14,18	CD154	27,32	CD40	CD154	958	959	Gene	Gene	Inhibition|nmod|START_ENTITY ligand|nsubj|Inhibition ligand|dep|END_ENTITY	Inhibition of CD40 ligand -LRB- CD154 -RRB- in the treatment of factor VIII inhibitors .
11297266	0	CD40	29,33	CD154	42,47	CD40	CD154	958	959	Gene	Gene	effects|nmod|START_ENTITY ligand|nsubj|effects ligand|dobj|END_ENTITY	Growth-inhibitory effects of CD40 ligand -LRB- CD154 -RRB- and its endogenous expression in human breast_cancer .
11488594	0	CD40	42,46	CD154	55,60	CD40	CD154	958	959	Gene	Gene	soluble|dep|START_ENTITY trimer|amod|soluble trimer|appos|END_ENTITY	Biophysical characterization of a soluble CD40 ligand -LRB- CD154 -RRB- coiled-coil trimer : evidence of a reversible acid-denatured molten globule .
11493450	0	CD40	123,127	CD154	40,45	CD40	CD154	958	959	Gene	Gene	limited|nmod|START_ENTITY limited|nsubj|action action|nmod|ligand ligand|appos|END_ENTITY	The inflammatory action of CD40 ligand -LRB- CD154 -RRB- expressed on activated human platelets is temporally limited by coexpressed CD40 .
11493450	0	CD40	27,31	CD154	40,45	CD40	CD154	958	959	Gene	Gene	ligand|nummod|START_ENTITY ligand|appos|END_ENTITY	The inflammatory action of CD40 ligand -LRB- CD154 -RRB- expressed on activated human platelets is temporally limited by coexpressed CD40 .
11592086	0	CD40	56,60	CD154	107,112	CD40	CD154	958	959	Gene	Gene	START_ENTITY|acl|using using|dobj|forms forms|nmod|ligand ligand|appos|END_ENTITY	Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand , CD154 .
11676606	0	CD40	111,115	CD154	121,126	CD40	CD154	100770242	959	Gene	Gene	interactions|nmod|START_ENTITY CD154|nmod|interactions N-linked|nmod|CD154 structures|amod|N-linked structures|nmod|END_ENTITY	Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia_pastoris and Chinese_hamster ovary cells .
11676606	0	CD40	111,115	CD154	61,66	CD40	CD154	100770242	959	Gene	Gene	interactions|nmod|START_ENTITY END_ENTITY|nmod|interactions	Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia_pastoris and Chinese_hamster ovary cells .
11687447	0	CD40	9,13	CD154	22,27	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY ligand|dobj|expression expression|appos|END_ENTITY	Abnormal CD40 ligand -LRB- CD154 -RRB- expression in human_immunodeficiency_virus-infected children .
11705814	0	CD40	16,20	CD154	38,43	CD40	CD154	958	959	Gene	Gene	Upregulation|nmod|START_ENTITY ligand|nsubj|Upregulation ligand|dep|END_ENTITY	Upregulation of CD40 and CD40 ligand -LRB- CD154 -RRB- in patients with moderate hypercholesterolemia .
11815953	0	CD40	14,18	CD154	27,32	CD40	CD154	958	959	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dep|END_ENTITY	Expression of CD40 ligand -LRB- CD154 -RRB- in B and T lymphocytes of Hodgkin_disease : potential therapeutic significance .
11891278	0	CD40	51,55	CD154	89,94	CD40	CD154	958	959	Gene	Gene	ligation|compound|START_ENTITY apoptosis|nmod|ligation sensitivity|nmod|apoptosis explain|nsubj|sensitivity explain|dobj|activity activity|nmod|therapy therapy|compound|END_ENTITY	Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic_lymphocytic_leukemia .
11895332	0	CD40	40,44	CD154	53,58	CD40	CD154	101085363	493850(Tax:9685)	Gene	Gene	activity|nmod|START_ENTITY Demonstration|nmod|activity ligand|nsubj|Demonstration ligand|dep|END_ENTITY	Demonstration of biological activity of CD40 ligand -LRB- CD154 -RRB- in the domestic_cat .
11929824	0	CD40	58,62	CD154	71,76	CD40	CD154	958	959	Gene	Gene	ligand|nummod|START_ENTITY ligand|appos|END_ENTITY	CD40-expressing carcinoma cells induce down-regulation of CD40 ligand -LRB- CD154 -RRB- and impair T-cell functions .
11986259	0	CD40	18,22	CD154	31,36	CD40	CD154	958	959	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	Levels of soluble CD40 ligand -LRB- CD154 -RRB- in serum are increased in human_immunodeficiency_virus_type_1-infected patients and correlate with CD4 -LRB- + -RRB- T-cell counts .
12517964	0	CD40	101,105	CD154	114,119	CD40	CD154	958	959	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	A complex containing polypyrimidine tract-binding protein is involved in regulating the stability of CD40 ligand -LRB- CD154 -RRB- mRNA .
12950679	0	CD40	22,26	CD154	35,40	CD40	CD154	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY IFN-gamma|nmod|expression IFN-gamma|nsubj|CD40L CD40L|appos|END_ENTITY	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
15780086	0	CD40	0,4	CD154	13,18	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|takes takes|nsubj|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- takes part in regulation of the transition to mononuclear cell dominance during peritonitis .
15859239	0	CD40	45,49	CD154	58,63	CD40	CD154	958	959	Gene	Gene	properties|nmod|START_ENTITY Conservation|nmod|properties ligand|nsubj|Conservation ligand|dobj|END_ENTITY	Conservation of biological properties of the CD40 ligand , CD154 in a non-mammalian vertebrate .
16777229	0	CD40	58,62	CD154	51,56	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY END_ENTITY|dep|ligand	Cloning , sequence analysis and expression of ovine CD154 -LRB- CD40 ligand -RRB- .
16893998	0	CD40	28,32	CD154	21,26	CD40	CD154	101793419	101789598	Gene	Gene	ligand|nsubj|START_ENTITY Immunotargeting|parataxis|ligand Immunotargeting|nmod|END_ENTITY	Immunotargeting with CD154 -LRB- CD40 ligand -RRB- enhances DNA vaccine responses in ducks .
17002639	0	CD40	26,30	CD154	39,44	CD40	CD154	958	959	Gene	Gene	association|nmod|START_ENTITY ligand|nsubj|association ligand|dep|END_ENTITY	An association of soluble CD40 ligand -LRB- CD154 -RRB- with adverse reactions to platelet transfusions .
17075342	0	CD40	18,22	CD154	108,113	CD40	CD154	958	959	Gene	Gene	macrophages|compound|START_ENTITY proportion|nmod|macrophages increased|nsubjpass|proportion increased|advcl|ligand ligand|ccomp|decreased decreased|dep|END_ENTITY	The proportion of CD40 + mucosal macrophages is increased in inflammatory_bowel_disease whereas CD40 ligand -LRB- CD154 -RRB- + T cells are relatively decreased , suggesting differential modulation of these costimulatory molecules in human gut lamina propria .
17075342	0	CD40	95,99	CD154	108,113	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|decreased decreased|dep|END_ENTITY	The proportion of CD40 + mucosal macrophages is increased in inflammatory_bowel_disease whereas CD40 ligand -LRB- CD154 -RRB- + T cells are relatively decreased , suggesting differential modulation of these costimulatory molecules in human gut lamina propria .
17225862	0	CD40	46,50	CD154	29,34	CD40	CD154	958	959	Gene	Gene	apoptosis|nummod|START_ENTITY preventing|dobj|apoptosis END_ENTITY|acl|preventing	C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis : a novel link between complement and epithelial cell survival .
18728056	0	CD40	40,44	CD154	53,58	CD40	CD154	958	959	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	The cardiovascular_risk factor , soluble CD40 ligand -LRB- CD154 -RRB- , but not soluble CD40 is lowered by ultra-endurance exercise in athletes .
18770718	0	CD40	15,19	CD154	28,33	CD40	CD154	958	959	Gene	Gene	Measurement|nmod|START_ENTITY ligand|nsubj|Measurement ligand|dobj|expression expression|appos|END_ENTITY	Measurement of CD40 ligand -LRB- CD154 -RRB- expression on resting and in vitro-activated T cells .
18941252	0	CD40	47,51	CD154	41,46	CD40	CD154	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	blockade|nummod|START_ENTITY promotes|nsubj|blockade conditioning|parataxis|promotes conditioning|dep|END_ENTITY	Strategic nonmyeloablative conditioning : CD154 : CD40 costimulatory blockade at primary bone marrow transplantation promotes engraftment for secondary bone marrow transplantation after engraftment failure .
19117935	0	CD40	85,89	CD154	91,96	CD40	CD154	958	959	Gene	Gene	patients|nmod|START_ENTITY fibroblasts|nmod|patients fibroblasts|dep|hyperinduces hyperinduces|nummod|END_ENTITY	Orbital fibroblasts from patients with thyroid-associated_ophthalmopathy overexpress CD40 : CD154 hyperinduces IL-6 , IL-8 , and MCP-1 .
19332074	0	CD40	85,89	CD154	28,33	CD40	CD154	958	959	Gene	Gene	stimulation|nummod|START_ENTITY source|nmod|stimulation used|nmod|source used|nsubj|Estimation Estimation|nmod|number number|nmod|molecules molecules|nummod|END_ENTITY	Estimation of the number of CD154 molecules in membrane extracts used as a source of CD40 stimulation of human B lymphocytes .
19656553	0	CD40	22,26	CD154	35,40	CD40	CD154	958	959	Gene	Gene	role|nmod|START_ENTITY ligand|nsubj|role ligand|dep|END_ENTITY	The role of platelets CD40 ligand -LRB- CD154 -RRB- in acute_coronary_syndromes .
22139839	0	CD40	84,88	CD154	97,102	CD40	CD154	958	959	Gene	Gene	BCL2|nmod|START_ENTITY contribute|xcomp|BCL2 contribute|dep|ligand ligand|dep|END_ENTITY	miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand -LRB- CD154 -RRB- in human leukemic B-cells .
22295117	0	CD40	14,18	CD154	41,46	CD40	CD154	958	959	Gene	Gene	Activation|nmod|START_ENTITY derived|nsubj|Activation derived|ccomp|promotes promotes|nsubj|END_ENTITY	Activation of CD40 with platelet derived CD154 promotes reactive_oxygen_species dependent death of human hepatocytes during hypoxia and reoxygenation .
22703674	0	CD40	0,4	CD154	13,18	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY ligand|dobj|involvement involvement|appos|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- involvement in platelet transfusion reactions .
9422418	0	CD40	0,4	CD154	22,27	CD40	CD154	958	959	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|coexpressed coexpressed|nsubjpass|END_ENTITY	CD40 and CD40 ligand -LRB- CD154 -RRB- are coexpressed on microvessels in vivo in human cardiac allograft rejection .
9550372	0	CD40	50,54	CD154	63,68	CD40	CD154	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY ligand|nsubj|effects ligand|dep|END_ENTITY	Immunostimulatory effects of a plasmid expressing CD40 ligand -LRB- CD154 -RRB- on gene immunization .
9570530	0	CD40	19,23	CD154	32,37	CD40	CD154	958	959	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	IL-12 up-regulates CD40 ligand -LRB- CD154 -RRB- expression on human T cells .
14556986	0	CD40	21,25	CD27	0,4	CD40	CD27	958	939	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	CD27 synergizes with CD40 to induce IgM , IgG , and IgA antibody responses of peripheral blood B cells in the presence of IL-2 and IL-10 .
9550398	0	CD40	0,4	CD27L	30,35	CD40	CD27L	21939(Tax:10090)	21948(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	CD40 and IL-4 regulate murine CD27L expression .
10458748	0	CD40	9,13	CD28	38,42	CD40	CD28	958	940	Gene	Gene	START_ENTITY|dep|interactions interactions|nummod|END_ENTITY	Blocking CD40 - CD154 and CD80/CD86 - CD28 interactions during primary allogeneic stimulation results in T cell anergy and high IL-10 production .
21899113	0	CD40	50,54	CD32	45,49	CD40	CD32	958	2212	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The determination of content of circulating CD32 + CD40 + micro particles : the modification of method of assessment of destruction of endothelial cells -RSB- .
19180486	0	CD40	24,28	CD34	44,48	CD40	CD34	958	947	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Increased expression of CD40 on bone marrow CD34 + hematopoietic progenitor cells in patients with systemic_lupus_erythematosus : contribution to Fas-mediated apoptosis .
10395323	0	CD40	97,101	CD4	29,32	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|nmod|START_ENTITY +|nmod|ligation +|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion of tumor-specific CD4 + T-cell tolerance to T-cell priming through in vivo ligation of CD40 .
10444266	0	CD40	10,14	CD4	35,38	CD40	CD4	958	920	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|cells cells|compound|END_ENTITY	Decreased CD40 ligand induction in CD4 T cells and dysregulated IL-12 production during HIV_infection .
10516078	0	CD40	16,20	CD4	29,32	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY ligand|nsubj|Requirement ligand|dobj|T T|compound|END_ENTITY	Requirement for CD40 ligand , CD4 -LRB- + -RRB- T cells , and B cells in an infectious_mononucleosis-like_syndrome .
10528180	0	CD40	0,4	CD4	29,32	CD40	CD4	958	920	Gene	Gene	blockade|nummod|START_ENTITY induces|nsubj|blockade induces|dobj|tolerance tolerance|compound|END_ENTITY	CD40 ligand blockade induces CD4 + T cell tolerance and linked suppression .
10590269	0	CD40	122,126	CD4	0,3	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY requires|dobj|expression T|ccomp|requires T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cell-mediated protection against a lethal outcome of systemic_infection with vesicular_stomatitis virus requires CD40 ligand expression , but not IFN-gamma or IL-4 .
10684857	0	CD40	0,4	CD4	42,45	CD40	CD4	958	920	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|triggers triggers|dobj|response response|compound|T T|compound|END_ENTITY	CD40 ligand -LRB- CD154 -RRB- triggers a short-term CD4 -LRB- + -RRB- T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis .
10700427	0	CD40	24,28	CD4	47,50	CD40	CD4	958	920	Gene	Gene	expression|nmod|START_ENTITY ligand|nsubj|expression ligand|dobj|CD154 CD154|nmod|cells cells|compound|END_ENTITY	Increased expression of CD40 ligand -LRB- CD154 -RRB- on CD4 + T cells as a marker of disease activity in rheumatoid_arthritis .
10936029	0	CD40	24,28	CD4	49,52	CD40	CD4	958	920	Gene	Gene	expression|nmod|START_ENTITY ligand|nsubj|expression ligand|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Increased expression of CD40 ligand in activated CD4 + T lymphocytes of systemic_sclerosis patients .
10940889	0	CD40	110,114	CD4	144,147	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induce|nmod|induction induce|dep|expression expression|nmod|cells cells|compound|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
11017148	0	CD40	48,52	CD4	146,149	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY modified|xcomp|express genetically|acl|modified initiate|nsubj|genetically initiate|dobj|independent independent|nmod|cells cells|compound|END_ENTITY	Dendritic_cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4 + T cells .
11034421	0	CD40	37,41	CD4	0,3	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + T lymphocytes with constitutive CD40 ligand in preautoimmune -LRB- NZB x NZW -RRB- F1 lupus-prone mice : phenotype and possible role in autoreactivity .
11120867	0	CD40	0,4	CD4	24,27	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY replaces|nsubj|signaling replaces|ccomp|prevents prevents|nsubj|lymphocytes lymphocytes|nummod|END_ENTITY	CD40 signaling replaces CD4 + lymphocytes and its blocking prevents chronic rejection of heart transplants .
11353832	0	CD40	16,20	CD4	40,43	CD40	CD4	958	920	Gene	Gene	Stimulation|nmod|START_ENTITY substitute|nsubj|Stimulation substitute|nmod|function function|compound|END_ENTITY	Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus .
11602857	0	CD40	16,20	CD4	66,69	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	Analysis|nmod|START_ENTITY pathways|nsubj|Analysis pathways|nmod|cells cells|nummod|END_ENTITY	Analysis of the CD40 and CD28 pathways on alloimmune responses by CD4 + T cells in vivo .
11698440	0	CD40	0,4	CD4	55,58	CD40	CD4	958	920	Gene	Gene	ligand|compound|START_ENTITY promotes|nsubj|ligand promotes|xcomp|priming priming|nmod|END_ENTITY	CD40 ligand promotes priming of fully potent antitumor CD4 -LRB- + -RRB- T cells in draining lymph nodes in the presence of apoptotic tumor cells .
11751400	0	CD40	0,4	CD4	57,60	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	cross-linking|compound|START_ENTITY bypasses|nsubj|cross-linking bypasses|dobj|requirement requirement|nmod|cells cells|compound|END_ENTITY	CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunization with melanoma antigen gene-modified dendritic cells .
12270549	0	CD40	0,4	CD4	42,45	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	stimulation|nummod|START_ENTITY inhibit|nsubj|stimulation inhibit|dobj|tolerance tolerance|compound|END_ENTITY	CD40 stimulation in vivo does not inhibit CD4 + T cell tolerance to soluble antigens .
12507785	0	CD40	0,4	CD4	58,61	CD40	CD4	958	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|adhesion adhesion|compound|END_ENTITY	CD40 expressed by human brain endothelial cells regulates CD4 + T cell adhesion to endothelium .
15294958	0	CD40	0,4	CD4	91,94	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY enhances|nsubj|engagement enhances|dobj|priming priming|nmod|+ +|compound|END_ENTITY	CD40 engagement enhances antigen-presenting langerhans cell priming of IFN-gamma-producing CD4 + and CD8 + T cells independently of IL-12 .
15634890	0	CD40	45,49	CD4	143,146	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY cells|nmod|stimulation CD70|nmod|cells Induction|nmod|CD70 contributes|nsubj|Induction contributes|nmod|absence absence|nmod|cells cells|compound|END_ENTITY	Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8 + T cell responses in the absence of CD4 + T cells .
15958635	0	CD40	71,75	CD4	48,51	CD40	CD4	958	920	Gene	Gene	gene|nummod|START_ENTITY vitro|nsubj|gene vitro|dobj|induction induction|nmod|END_ENTITY	In vitro induction of myeloid_leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins .
16365447	0	CD40	30,34	CD4	0,3	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY expressing|ccomp|ligand lymphocytes|xcomp|expressing lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell type .
18354158	0	CD40	0,4	CD4	117,120	CD40	CD4	958	920	Gene	Gene	needed|nsubjpass|START_ENTITY needed|nmod|absence absence|nmod|help help|compound|END_ENTITY	CD40 on APCs is needed for optimal programming , maintenance , and recall of CD8 + T cell memory even in the absence of CD4 + T cell help .
18469093	0	CD40	66,70	CD4	62,65	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
19670423	0	CD40	44,48	CD4	0,3	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY inflammation|nmod|signaling promote|dobj|inflammation promote|nsubj|cells cells|compound|END_ENTITY	CD4 T cells promote tissue inflammation via CD40 signaling without de novo activation in a murine model of liver_ischemia / reperfusion_injury .
19778641	0	CD40	78,82	CD4	21,24	CD40	CD4	958	920	Gene	Gene	ligand|nummod|START_ENTITY expression|nmod|ligand inducing|dobj|expression T-cell|advcl|inducing T-cell|nsubj|END_ENTITY	Doxorubicin enhances CD4 -LRB- + -RRB- T-cell immune responses by inducing expression of CD40 ligand and 4-1BB .
22002241	0	CD40	35,39	CD4	56,59	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	drives|compound|START_ENTITY drives|dep|+ +|compound|END_ENTITY	Intratumoral interleukin-2 / agonist CD40 antibody drives CD4 + - independent resolution of treated-tumors and CD4 + - dependent systemic and memory responses .
22105491	0	CD40	0,4	CD4	19,22	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|nummod|START_ENTITY engagement|nmod|cells cells|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
22105491	0	CD40	24,28	CD4	19,22	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
22851303	0	CD40	70,74	CD4	128,131	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|xcomp|expression expression|nmod|cells cells|compound|END_ENTITY	Differential modulation by delta9-tetrahydrocannabinol -LRB- 9 -RRB- - THC -RRB- of CD40 ligand -LRB- CD40L -RRB- expression in activated mouse splenic CD4 + T cells .
23615121	0	CD40	45,49	CD4	96,99	CD40	CD4	958	920	Gene	Gene	Targeting|nmod|START_ENTITY expands|csubj|Targeting expands|dobj|repertoire repertoire|nmod|+ +|compound|END_ENTITY	Targeting concatenated HIV antigens to human CD40 expands a broad repertoire of multifunctional CD4 + and CD8 + T cells .
7509825	0	CD40	0,4	CD4	47,50	CD40	CD4	958	920	Gene	Gene	costimulates|nsubj|START_ENTITY costimulates|dobj|activation activation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD40 preferentially costimulates activation of CD4 + T lymphocytes .
7699321	0	CD40	51,55	CD4	12,15	CD40	CD4	958	920	Gene	Gene	ligand|compound|START_ENTITY contains|dobj|ligand contains|nsubj|subset subset|nmod|cells cells|compound|END_ENTITY	A subset of CD4 + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex .
8103067	0	CD40	46,50	CD4	80,83	CD40	CD4	958	920	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|cells cells|nummod|END_ENTITY	The regulation of the expression of gp39 , the CD40 ligand , on normal and cloned CD4 + T cells .
8605928	0	CD40	44,48	CD4	81,84	CD40	CD4	958	920	Gene	Gene	START_ENTITY|acl|ligand ligand|nmod|cells cells|compound|END_ENTITY	Endothelial cells augment the expression of CD40 ligand on newly activated human CD4 + T cells through a CD2/LFA -3 signaling pathway .
8892618	0	CD40	94,98	CD4	38,41	CD40	CD4	958	920	Gene	Gene	ligand|compound|START_ENTITY help|nmod|ligand provide|dobj|help provide|nsubj|cells cells|compound|END_ENTITY	Herpesvirus_saimiri-transformed human CD4 + T cells can provide polyclonal B cell help via the CD40 ligand as well as the TNF-alpha pathway and through release of lymphokines .
8977172	0	CD40	12,16	CD4	49,52	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY Blockade|nmod|interaction impairs|nsubj|Blockade impairs|dobj|T T|compound|END_ENTITY	Blockade of CD40 ligand-CD40 interaction impairs CD4 + T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation .
8977315	0	CD40	53,57	CD4	96,99	CD40	CD4	958	920	Gene	Gene	ligand|nsubj|START_ENTITY TRAP|parataxis|ligand TRAP|nmod|interaction interaction|nmod|cells cells|compound|END_ENTITY	Induction , regulation , and function of soluble TRAP -LRB- CD40 ligand -RRB- during interaction of primary CD4 + CD45RA + T cells with dendritic cells .
9012830	0	CD40	111,115	CD4	94,97	CD40	CD4	958	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Increased interleukin 12 production in progressive multiple_sclerosis : induction by activated CD4 + T cells via CD40 ligand .
9151338	0	CD40	89,93	CD4	0,3	CD40	CD4	958	920	Gene	Gene	ability|nmod|START_ENTITY have|dobj|ability have|nsubj|cells cells|nummod|END_ENTITY	CD4 + cells from patients with Common_Variable_Immunodeficiency have a reduced ability of CD40 ligand membrane expression after in vitro stimulation .
9257841	0	CD40	98,102	CD4	66,69	CD40	CD4	21939(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligand|nummod|START_ENTITY role|nmod|ligand Induction|dep|role Induction|nmod|markers markers|nmod|lymphocytes lymphocytes|amod|vitro vitro|nmod|T T|compound|END_ENTITY	Induction of germinal center B cell markers in vitro by activated CD4 + T lymphocytes : the role of CD40 ligand , soluble factors , and B cell antigen receptor cross-linking .
9682002	0	CD40	24,28	CD4	61,64	CD40	CD4	958	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Glucocorticoids inhibit CD40 ligand expression of peripheral CD4 + lymphocytes .
11818376	0	CD40	0,4	CD40	57,61	CD40	CD40	958	958	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	CD40 expression in normal human cornea and regulation of CD40 in cultured human corneal epithelial and stromal cells .
11818376	0	CD40	57,61	CD40	0,4	CD40	CD40	958	958	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	CD40 expression in normal human cornea and regulation of CD40 in cultured human corneal epithelial and stromal cells .
20400702	0	CD40	0,4	CD40	22,26	CD40	CD40	21939(Tax:10090)	21939(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	CD40 signaling in CD8 + CD40 + T cells turns on contra-T regulatory cell functions .
20400702	0	CD40	22,26	CD40	0,4	CD40	CD40	21939(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	CD40 signaling in CD8 + CD40 + T cells turns on contra-T regulatory cell functions .
22105491	0	CD40	0,4	CD40	24,28	CD40	CD40	21939(Tax:10090)	21939(Tax:10090)	Gene	Gene	engagement|nummod|START_ENTITY engagement|nmod|cells cells|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
22105491	0	CD40	24,28	CD40	0,4	CD40	CD40	21939(Tax:10090)	21939(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells engagement|nummod|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
23073798	0	CD40	14,18	CD40	48,52	CD40	CD40	958	958	Gene	Gene	START_ENTITY|nmod|ligand ligand|compound|END_ENTITY	Activation of CD40 by soluble recombinant human CD40 ligand inhibits human glioma cells proliferation via nuclear factor-kB signaling pathway .
23073798	0	CD40	48,52	CD40	14,18	CD40	CD40	958	958	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|nmod|ligand	Activation of CD40 by soluble recombinant human CD40 ligand inhibits human glioma cells proliferation via nuclear factor-kB signaling pathway .
10201021	0	CD40	0,4	CD40L	60,65	CD40	CD40L	958	959	Gene	Gene	expression|nummod|START_ENTITY expression|appos|END_ENTITY	CD40 expression on graft infiltrates and parenchymal CD154 -LRB- CD40L -RRB- induction in human chronic renal allograft rejection .
10566730	0	CD40	14,18	CD40L	35,40	CD40	CD40L	958	959	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD40 and its ligand , CD40L , in intestinal lesions of Crohn 's _ disease .
11297035	0	CD40	9,13	CD40L	22,27	CD40	CD40L	958	959	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	Platelet CD40 ligand -LRB- CD40L -RRB- -- subcellular localization , regulation of expression , and inhibition by clopidogrel .
11817328	0	CD40	0,4	CD40L	5,10	CD40	CD40L	958	959	Gene	Gene	START_ENTITY|dep|interactions interactions|nummod|END_ENTITY	CD40 : CD40L interactions in X-linked_and_non-X-linked_hyper-IgM_syndromes .
12036894	0	CD40	72,76	CD40L	77,82	CD40	CD40L	958	959	Gene	Gene	blockade|nmod|START_ENTITY cells|nmod|blockade induction|nmod|cells induction|dep|results results|nummod|END_ENTITY	Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40 : CD40L costimulatory pathway results in the generation of a potent immune regulatory cell .
12771917	1	CD40	76,80	CD40L	147,152	CD40	CD40L	958	959	Gene	Gene	cells|compound|START_ENTITY undergo|nsubj|cells Evidence|dep|undergo apoptosis|nsubj|Evidence apoptosis|nmod|interaction interaction|nmod|END_ENTITY	Evidence that CD40 + neuroblastoma cells undergo apoptosis following interaction with CD40L .
12950679	0	CD40	22,26	CD40L	28,33	CD40	CD40L	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY IFN-gamma|nmod|expression IFN-gamma|nsubj|END_ENTITY	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
15623492	0	CD40	28,32	CD40L	41,46	CD40	CD40L	958	959	Gene	Gene	ligand|advmod|START_ENTITY gene|amod|ligand gene|appos|END_ENTITY	Mutational screening of the CD40 ligand -LRB- CD40L -RRB- gene in patients with X_linked_hyper-IgM_syndrome -LRB- XHIM -RRB- and determination of carrier status in female relatives .
15698512	0	CD40	35,39	CD40L	81,86	CD40	CD40L	958	959	Gene	Gene	ligation|nummod|START_ENTITY ligation|acl|mediated mediated|nmod|END_ENTITY	Differential downstream effects of CD40 ligation mediated by membrane or soluble CD40L and agonistic Ab : a study on purified human B cells .
15968400	0	CD40	12,16	CD40L	20,25	CD40	CD40L	958	959	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	The role of CD40 in CD40L - and antibody-mediated platelet activation .
16213477	0	CD40	38,42	CD40L	117,122	CD40	CD40L	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|induction induction|acl|killing killing|nmod|END_ENTITY	Constitutive expression of functional CD40 on mouse renal_cancer cells : induction of Fas and Fas-mediated killing by CD40L .
17319699	0	CD40	66,70	CD40L	46,51	CD40	CD40L	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	mimetics|nmod|START_ENTITY mimetics|nsubj|Cooperativity Cooperativity|nmod|interaction interaction|nmod|END_ENTITY	Cooperativity in the interaction of synthetic CD40L mimetics with CD40 and its implication in cell signaling .
19734779	0	CD40	25,29	CD40L	44,49	CD40	CD40L	958	959	Gene	Gene	platelet|nummod|START_ENTITY Upregulation|nmod|platelet ligand|nsubj|Upregulation ligand|dobj|END_ENTITY	Upregulation of platelet CD40 , CD40 ligand -LRB- CD40L -RRB- and P-Selectin expression in cigarette smokers : a flow cytometry study .
19734779	0	CD40	31,35	CD40L	44,49	CD40	CD40L	958	959	Gene	Gene	platelet|nummod|START_ENTITY Upregulation|nmod|platelet ligand|nsubj|Upregulation ligand|dobj|END_ENTITY	Upregulation of platelet CD40 , CD40 ligand -LRB- CD40L -RRB- and P-Selectin expression in cigarette smokers : a flow cytometry study .
22561578	0	CD40	30,34	CD40L	36,41	CD40	CD40L	958	959	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Developments in the study of CD40 / CD40L gene and its polymorphism in atherosclerosis -RSB- .
22851303	0	CD40	70,74	CD40L	83,88	CD40	CD40L	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|xcomp|expression expression|dep|END_ENTITY	Differential modulation by delta9-tetrahydrocannabinol -LRB- 9 -RRB- - THC -RRB- of CD40 ligand -LRB- CD40L -RRB- expression in activated mouse splenic CD4 + T cells .
25908768	0	CD40	90,94	CD40L	9,14	CD40	CD40L	21939(Tax:10090)	21947(Tax:10090)	Gene	Gene	Phosphatidylinositol|dep|START_ENTITY Phosphatidylinositol|compound|END_ENTITY	Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase b , and Not Via CD40 and IkB kinase a. OBJECTIVE : To investigate the roles and signaling pathways of CD40L and CD40 in platelet-platelet interactions and thrombus formation under conditions relevant for atherothrombosis .
25992978	0	CD40	22,26	CD40L	47,52	CD40	CD40L	958	959	Gene	Gene	START_ENTITY|nmod|Cells Cells|nmod|END_ENTITY	Direct Interaction of CD40 on Tumor Cells with CD40L on T Cells Increases the Proliferation of Tumor Cells by Enhancing TGF-b Production and Th17 Differentiation .
26483316	0	CD40	61,65	CD40L	67,72	CD40	CD40L	707749(Tax:9544)	574160(Tax:9544)	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Gene expression and TB pathogenesis in rhesus_macaques : TR4 , CD40 , CD40L , FAS -LRB- CD95 -RRB- , and TNF are host genetic markers in peripheral blood mononuclear cells that are associated with severity of TB_lesions .
7532462	0	CD40	25,29	CD40L	12,17	CD40	CD40L	958	959	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of CD40L -LRB- gp39 -RRB- / CD40 in T/B cell interaction and primary immunodeficiency .
9605317	0	CD40	87,91	CD40L	63,68	CD40	CD40L	958	959	Gene	Gene	role|nmod|START_ENTITY role|nmod|recognition recognition|nmod|END_ENTITY	The role of polar interactions in the molecular recognition of CD40L with its receptor CD40 .
16904975	0	CD40	49,53	CD40_ligand	0,11	CD40	CD40 ligand	958	959	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	CD40_ligand increases expression of its receptor CD40 in human coronary artery endothelial cells .
25062112	0	CD40	125,129	CD70	24,28	CD40	CD70	958	970	Gene	Gene	Stimulation|compound|START_ENTITY END_ENTITY|nmod|Stimulation	Significantly Increased CD70 Up Regulation on TEL-AML Positive B Cell Precursor Acute Lymphoblastic_Leukemia Cells Following CD40 Stimulation .
9622100	0	CD40	80,84	CD70	51,55	CD40	CD70	21939(Tax:10090)	21948(Tax:10090)	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|appos|ligand	Enhancement of antitumor immunity by expression of CD70 -LRB- CD27_ligand -RRB- or CD154 -LRB- CD40 ligand -RRB- costimulatory molecules in tumor cells .
10329842	0	CD40	37,41	CD8	58,61	CD40	CD8	958	925	Gene	Gene	IL-4|nmod|START_ENTITY Production|nmod|IL-4 ligand|nsubj|Production ligand|nmod|cells cells|compound|END_ENTITY	Production of IL-4 and expression of CD40 ligand by human CD8 T cells .
11714787	0	CD40	161,165	CD8	130,133	CD40	CD8	958	925	Gene	Gene	ligation|compound|START_ENTITY essential|nsubj|ligation generate|advcl|essential generate|dobj|cells cells|amod|CTLs CTLs|nmod|T T|compound|END_ENTITY	Lipopolysaccharide modulation of dendritic cells is insufficient to mature dendritic cells to generate CTLs from naive polyclonal CD8 + T cells in vitro , whereas CD40 ligation is essential .
11901196	0	CD40	46,50	CD8	20,23	CD40	CD8	958	925	Gene	Gene	cells|nummod|START_ENTITY T|nmod|cells T|nsubj|Generation Generation|nmod|END_ENTITY	Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells .
12242444	0	CD40	11,15	CD8	30,33	CD40	CD8	958	925	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|cells cells|compound|END_ENTITY	A role for CD40 expression on CD8 + T cells in the generation of CD8 + T cell memory .
12242444	0	CD40	11,15	CD8	64,67	CD40	CD8	958	925	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|generation generation|nmod|memory memory|compound|END_ENTITY	A role for CD40 expression on CD8 + T cells in the generation of CD8 + T cell memory .
12581766	0	CD40	52,56	CD8	0,3	CD40	CD8	958	925	Gene	Gene	combination|compound|START_ENTITY induce|nmod|combination T|ccomp|induce T|nsubj|END_ENTITY	CD8 -LRB- + -RRB- T cells induce graft vascular_occlusion in a CD40 knockout donor/recipient combination .
14647233	0	CD40	94,98	CD8	175,178	CD40	CD8	958	925	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells antigens|nmod|cells delivery|nmod|antigens resulted|nsubj|delivery resulted|nmod|activation activation|nmod|cells cells|compound|END_ENTITY	Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8 + T cells .
15004136	0	CD40	78,82	CD8	25,28	CD40	CD8	958	925	Gene	Gene	expression|nummod|START_ENTITY absence|nmod|expression memory|nmod|absence memory|compound|END_ENTITY	Cutting edge : long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells .
15004136	0	CD40	78,82	CD8	97,100	CD40	CD8	958	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Cutting edge : long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells .
15827964	0	CD40	28,32	CD8	73,76	CD40	CD8	958	925	Gene	Gene	tolerance|compound|START_ENTITY tolerance|acl|induction induction|nmod|cells cells|compound|END_ENTITY	Split peripheral tolerance : CD40 ligation blocks tolerance induction for CD8 T cells but not for CD4 T cells in response to intestinal antigens .
19002156	0	CD40	0,4	CD8	90,93	CD40	CD8	958	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|acl:relcl|contributes contributes|nmod|END_ENTITY	CD40 regulates human dendritic cell-derived IL-7 production that , in turn , contributes to CD8 -LRB- + -RRB- T-cell antigen-specific expansion .
23853599	0	CD40	0,4	CD8	34,37	CD40	CD8	958	925	Gene	Gene	activation|compound|START_ENTITY rescues|nsubj|activation rescues|dobj|cells cells|compound|END_ENTITY	CD40 activation rescues antiviral CD8 T cells from PD-1-mediated exhaustion .
23858029	0	CD40	34,38	CD8	14,17	CD40	CD8	958	925	Gene	Gene	signals|compound|START_ENTITY signals|compound|END_ENTITY	Inhibition of CD8 + T cell-derived CD40 signals is necessary but not sufficient for Foxp3 + induced regulatory T cell generation in vivo .
23971530	0	CD40	0,4	CD8	32,35	CD40	CD8	958	925	Gene	Gene	START_ENTITY|dep|perspective perspective|compound|END_ENTITY	CD40 signaling to the rescue : A CD8 exhaustion perspective in chronic infectious_diseases .
24108445	0	CD40	95,99	CD8	33,36	CD40	CD8	958	925	Gene	Gene	signaling|compound|START_ENTITY relies|nmod|signaling relies|nsubj|dependence dependence|nmod|expansion expansion|nummod|END_ENTITY	T-cell help dependence of memory CD8 + T-cell expansion upon vaccinia_virus challenge relies on CD40 signaling .
24801648	0	CD40	0,4	CD8	76,79	CD40	CD8	958	925	Gene	Gene	expression|nummod|START_ENTITY associated|nsubjpass|expression associated|nmod|apoptosis apoptosis|appos|T T|compound|END_ENTITY	CD40 expression in renal_cell_carcinoma is associated with tumor apoptosis , CD8 -LRB- + -RRB- T cell frequency and patient survival .
9717983	0	CD40	67,71	CD8	51,54	CD40	CD8	958	925	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|nmod|forms forms|nmod|END_ENTITY	Surface expression and release of soluble forms of CD8 and CD23 in CD40 - and IL-4-activated mononuclear cells from patients with Graves ' _ disease -LRB- GD -RRB- .
12608645	0	CD40	0,4	COX-2	23,28	CD40	COX-2	958	4513	Gene	Gene	ligation|compound|START_ENTITY triggers|nsubj|ligation triggers|dobj|expression expression|compound|END_ENTITY	CD40 ligation triggers COX-2 expression in endothelial cells : evidence that CD40-mediated IL-6 synthesis is COX-2-dependent .
18093816	0	CD40	26,30	COX-2	0,5	CD40	COX-2	958	4513	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells .
22105491	0	CD40	24,28	CTLA-4	82,88	CD40	CTLA-4	21939(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells ablates|nsubj|engagement ablates|dobj|expression expression|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
16311507	0	CD40	80,84	Daxx	40,44	CD40	Daxx	958	1616	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The PML-nuclear body associated protein Daxx regulates the cellular response to CD40 .
16356505	0	CD40	32,36	ERK	56,59	CD40	ERK	958	5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Chylomicron remnants upregulate CD40 expression via the ERK pathway and a redox-sensitive mechanism in THP-1 cells .
15946919	0	CD40	21,25	Endothelin-1	0,12	CD40	Endothelin-1	958	1906	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Endothelin-1 induces CD40 but not IL-6 in human monocytes via the proinflammatory transcription factor NF-kappaB .
17507309	0	CD40	41,45	Endothelin-1	0,12	CD40	Endothelin-1	958	1906	Gene	Gene	protein|compound|START_ENTITY induces|dobj|protein induces|nsubj|END_ENTITY	Endothelin-1 induces functionally active CD40 protein via nuclear factor-kappaB in human vascular smooth muscle cells .
23858029	0	CD40	34,38	Foxp3	83,88	CD40	Foxp3	958	50943	Gene	Gene	signals|compound|START_ENTITY Inhibition|nmod|signals sufficient|nsubj|Inhibition sufficient|nmod|+ +|compound|END_ENTITY	Inhibition of CD8 + T cell-derived CD40 signals is necessary but not sufficient for Foxp3 + induced regulatory T cell generation in vivo .
22685601	0	CD40	20,24	Galectin-9	0,10	CD40	Galectin-9	21939(Tax:10090)	16859(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity .
10201939	0	CD40	0,4	IFN-gamma	94,103	CD40	IFN-gamma	958	3458	Gene	Gene	interaction|nummod|START_ENTITY induces|nsubj|interaction induces|nmod|END_ENTITY	CD40 ligand-CD40 interaction induces chemokines in cervical_carcinoma cells in synergism with IFN-gamma .
10510353	0	CD40	89,93	IFN-gamma	25,34	CD40	IFN-gamma	958	3458	Gene	Gene	proliferation|nummod|START_ENTITY effects|nmod|proliferation switching|nsubj|effects Integrating|parataxis|switching Integrating|nmod|END_ENTITY	Integrating signals from IFN-gamma and IL-4 by B cells : positive and negative effects on CD40 ligand-induced proliferation , survival , and division-linked isotype switching to IgG1 , IgE , and IgG2a .
12950679	0	CD40	22,26	IFN-gamma	61,70	CD40	IFN-gamma	21939(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
16864989	0	CD40	40,44	IFN-gamma	67,76	CD40	IFN-gamma	958	3458	Gene	Gene	expression|nmod|START_ENTITY 15d-PGJ2|nmod|expression Effect|nmod|15d-PGJ2 induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells -LRB- HK-2 -RRB- .
17015727	0	CD40	40,44	IFN-gamma	71,80	CD40	IFN-gamma	21939(Tax:10090)	15978(Tax:10090)	Gene	Gene	gamma2a|nmod|START_ENTITY expression|nmod|gamma2a ligation|nsubj|expression ligation|nmod|END_ENTITY	Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma .
19171874	0	CD40	70,74	IFN-gamma	13,22	CD40	IFN-gamma	958	3458	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway enhances|nmod|cells enhances|dobj|production production|amod|END_ENTITY	C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells .
9469427	0	CD40	12,16	IFN-gamma	57,66	CD40	IFN-gamma	958	3458	Gene	Gene	stimulation|compound|START_ENTITY regulates|nsubj|stimulation regulates|dobj|production production|nmod|END_ENTITY	CD40_ligand / CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12 - and/or CD28-dependent manner .
10843746	0	CD40	33,37	IL-10	14,19	CD40	IL-10	958	3586	Gene	Gene	cells|compound|START_ENTITY Production|nmod|cells Production|nmod|END_ENTITY	Production of IL-10 and IL-12 in CD40 and interleukin_4-activated mononuclear cells from patients with Graves ' _ disease .
10942246	0	CD40	52,56	IL-10	39,44	CD40	IL-10	958	3586	Gene	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Mantle_cell_lymphoma proliferates upon IL-10 in the CD40 system .
11792123	0	CD40	0,4	IL-10	33,38	CD40	IL-10	958	3586	Gene	Gene	ligation|compound|START_ENTITY induces|nsubj|ligation induces|dobj|END_ENTITY	CD40 ligation induces macrophage IL-10 and TNF-alpha production : differential use of the PI3K and p42/44 MAPK-pathways .
12209589	0	CD40	14,18	IL-10	89,94	CD40	IL-10	21939(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY Inhibition|nmod|expression function|nsubj|Inhibition function|nmod|END_ENTITY	Inhibition of CD40 expression and CD40-mediated dendritic cell function by tumor-derived IL-10 .
17114447	0	CD40	42,46	IL-10	0,5	CD40	IL-10	958	3586	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor_of_cytokine_signaling-3 .
25341924	0	CD40	80,84	IL-10	25,30	CD40	IL-10	21939(Tax:10090)	16153(Tax:10090)	Gene	Gene	CD5|compound|START_ENTITY enrichment|nmod|CD5 critical|nmod|enrichment cells|amod|critical cells|nsubj|stimulation stimulation|nmod|END_ENTITY	Autocrine stimulation of IL-10 is critical to the enrichment of IL-10-producing CD40 -LRB- hi -RRB- CD5 -LRB- + -RRB- regulatory B cells in vitro and in vivo .
22593619	0	CD40	32,36	IL-15Ra	10,17	CD40	IL-15Ra	21939(Tax:10090)	16169(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Augmented IL-15Ra expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice .
9278293	0	CD40	98,102	IL-4	135,139	CD40	IL-4	958	3565	Gene	Gene	ligation|compound|START_ENTITY ligation|nmod|END_ENTITY	Memory , but not naive , peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2 , IL-10 , and IL-3 .
19002156	0	CD40	0,4	IL-7	44,48	CD40	IL-7	958	3574	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	CD40 regulates human dendritic cell-derived IL-7 production that , in turn , contributes to CD8 -LRB- + -RRB- T-cell antigen-specific expansion .
9133417	0	CD40	24,28	Jak3	0,4	CD40	Jak3	958	3718	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells .
17660512	0	CD40	15,19	Leptin	0,6	CD40	Leptin	21939(Tax:10090)	16846(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin induces CD40 expression through the activation of Akt in murine dendritic cells .
15598810	0	CD40	44,48	MALT1	0,5	CD40	MALT1	958	10892	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa_B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells .
15670770	0	CD40	69,73	MAP3K8	56,62	CD40	MAP3K8	958	1326	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	TRAF-dependent association of protein kinase Tpl2/COT1 -LRB- MAP3K8 -RRB- with CD40 .
23429328	0	CD40	8,12	PI3K	25,29	CD40	PI3K	958	5293	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
23419881	0	CD40	8,12	PrP	69,72	CD40	PrP	21939(Tax:10090)	19122(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CD40 in prion disease and the immune response to recombinant PrP .
24037181	0	CD40	0,4	RAG1	29,33	CD40	RAG1	958	5896	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression .
8683159	0	CD40	70,74	Rel	38,41	CD40	Rel	21939(Tax:10090)	19696(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Maintenance of nuclear_factor-kappa_B / Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins .
23075766	0	CD40	16,20	SIRT1	0,5	CD40	SIRT1	958	23411	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SIRT1 regulates CD40 expression induced by TNF-a via NF - B pathway in endothelial cells .
16571771	0	CD40	45,49	SOCS-1	17,23	CD40	SOCS-1	958	8651	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia .
11086058	0	CD40	49,53	STAT-6	15,21	CD40	STAT-6	958	6778	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia .
10995749	0	CD40	20,24	Smad7	0,5	CD40	Smad7	21939(Tax:10090)	17131(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta - induced growth inhibition and apoptosis .
22547990	0	CD40	29,33	TNF-a	0,5	CD40	TNF-a	958	7124	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	TNF-a promotes IFN-y-induced CD40 expression and antigen process in Myb-transformed hematological cells .
21074606	0	CD40	23,27	TNFR1	0,5	CD40	TNFR1	21939(Tax:10090)	21937(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	TNFR1 is essential for CD40 , but not for lipopolysaccharide-induced sickness_behavior and clock gene dysregulation .
9379019	0	CD40	85,89	TNF_receptor-associated_factor_2	45,77	CD40	TNF receptor-associated factor 2	958	7186	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	CD40-mediated signals inhibit the binding of TNF_receptor-associated_factor_2 to the CD40 cytoplasmic domain .
22699883	0	CD40	35,39	TNFa	0,4	CD40	TNFa	958	7124	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	TNFa regulates the localization of CD40 in lipid rafts of glioma cells .
12958312	0	CD40	115,119	TRAF2	106,111	CD40	TRAF2	21939(Tax:10090)	22030(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- - deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling .
8790348	0	CD40	89,93	TRAF5	0,5	CD40	TRAF5	958	7188	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	TRAF5 , a novel tumor necrosis factor receptor-associated factor family protein , mediates CD40 signaling .
23918987	0	CD40	30,34	TWEAK	0,5	CD40	TWEAK	958	8742	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes .
23918987	0	CD40	67,71	TWEAK	0,5	CD40	TWEAK	958	8742	Gene	Gene	destabilization|nmod|START_ENTITY signaling|nmod|destabilization CD40|acl|signaling inhibits|dobj|CD40 inhibits|nsubj|END_ENTITY	TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes .
15708600	0	CD40	49,53	Tax	35,38	CD40	Tax	958	6900	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Human_T_cell_leukemia_virus_type_I Tax activates CD40 gene expression via the NF-kappa_B pathway .
10940889	0	CD40	110,114	Th2	66,69	CD40	Th2	21939(Tax:10090)	15111(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
11777943	0	CD40	68,72	Th2	14,17	CD40	Th2	21939(Tax:10090)	15111(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY edge|dep|role edge|dep|induction induction|amod|END_ENTITY	Cutting edge : Th2 response induction by dendritic cells : a role for CD40 .
9808207	0	CD40	0,4	Th2	72,75	CD40	Th2	21939(Tax:10090)	15111(Tax:10090)	Gene	Gene	signals|nummod|START_ENTITY signals|dep|role role|nmod|development development|amod|END_ENTITY	CD40 ligand signals optimize T helper cell cytokine production : role in Th2 development and induction of germinal centers .
18418252	0	CD40	19,23	Thrombin	0,8	CD40	Thrombin	958	2147	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Thrombin regulates CD40 expression in microglial cells .
12881420	0	CD40	16,20	Tpl2	0,4	CD40	Tpl2	21939(Tax:10090)	26410(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY transduces|dobj|signals transduces|nsubj|END_ENTITY	Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40 .
20006573	0	CD40	49,53	Tumor_Necrosis_Factor_alpha	0,27	CD40	Tumor Necrosis Factor alpha	958	7124	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_Necrosis_Factor_alpha -LRB- TNFalpha -RRB- regulates CD40 expression through SMAR1 phosphorylation .
12958312	0	CD40	115,119	Tumor_necrosis_factor_receptor-associated_factor_2	0,50	CD40	Tumor necrosis factor receptor-associated factor 2	21939(Tax:10090)	22030(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY TRAF2|nmod|signaling reveal|nmod|TRAF2 deficient|acl:relcl|reveal END_ENTITY|dep|deficient	Tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- - deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling .
9432981	0	CD40	126,130	Tumor_necrosis_factor_receptor-associated_factor_6	0,50	CD40	Tumor necrosis factor receptor-associated factor 6	958	7189	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
23429328	0	CD40	8,12	VEGF	14,18	CD40	VEGF	958	7422	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
11922943	0	CD40	47,51	c-Rel	0,5	CD40	c-Rel	958	5966	Gene	Gene	responsive|dep|START_ENTITY element|dep|responsive activator|nmod|element activator|nsubj|END_ENTITY	c-Rel is a selective activator of a novel IL-4 / CD40 responsive element in the human Ig gamma4 germline promoter .
17567982	0	CD40	8,12	c-Rel	28,33	CD40	c-Rel	958	5966	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell_lymphoma .
9305612	0	CD40	28,32	c-kit	10,15	CD40	c-kit	958	3815	Gene	Gene	CD30|dep|START_ENTITY JURL-MK1|dep|CD30 JURL-MK1|dep|high high|amod|END_ENTITY	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
9305612	0	CD40	66,70	c-kit	49,54	CD40	c-kit	958	3815	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
15447673	0	CD40	61,65	cyclooxygenase-2	13,29	CD40	cyclooxygenase-2	21939(Tax:10090)	19225(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway END_ENTITY|nmod|cells	Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway : relevance to amyotrophic_lateral_sclerosis .
15838273	0	CD40	90,94	endothelin-1	13,25	CD40	endothelin-1	958	1906	Gene	Gene	action|nmod|START_ENTITY cells|nmod|action production|nmod|cells production|amod|END_ENTITY	Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor -LRB- LOX-1 -RRB- .
9432981	0	CD40	126,130	extracellular_signal-regulated_kinase	70,107	CD40	extracellular signal-regulated kinase	958	5594	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
1385114	0	CD40	84,88	gp39	131,135	CD40	gp39	958	959	Gene	Gene	receptor|compound|START_ENTITY ligand|nmod|receptor ligand|dep|expression expression|nmod|form form|nmod|END_ENTITY	The human T_cell_antigen_gp39 , a member of the TNF gene family , is a ligand for the CD40 receptor : expression of a soluble form of gp39 with B cell co-stimulatory activity .
16509032	0	CD40	41,45	gp39	54,58	CD40	gp39	958	959	Gene	Gene	mutations|nmod|START_ENTITY Classification|nmod|mutations ligand|nsubj|Classification ligand|dobj|END_ENTITY	Classification of mutations in the human CD40 ligand , gp39 , that are associated with X-linked_hyper_IgM_syndrome .
7521888	0	CD40	26,30	gp39	32,36	CD40	gp39	958	959	Gene	Gene	ligand|nmod|START_ENTITY Antibody|nmod|ligand Antibody|appos|END_ENTITY	Antibody to the ligand of CD40 , gp39 , blocks the occurrence of the acute and chronic forms of graft-vs-host_disease .
7532456	0	CD40	22,26	gp39	43,47	CD40	gp39	958	959	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The expansive role of CD40 and its ligand , gp39 , in immunity .
7532462	0	CD40	25,29	gp39	19,23	CD40	gp39	958	959	Gene	Gene	role|dep|START_ENTITY role|nmod|CD40L CD40L|appos|END_ENTITY	The role of CD40L -LRB- gp39 -RRB- / CD40 in T/B cell interaction and primary immunodeficiency .
7678782	0	CD40	4,8	gp39	17,21	CD40	gp39	958	959	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	The CD40 ligand , gp39 , is defective in activated T cells from patients with X-linked_hyper-IgM_syndrome .
7689748	0	CD40	82,86	gp39	61,65	CD40	gp39	21939(Tax:10090)	21939(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Prevention of collagen-induced arthritis with an antibody to gp39 , the ligand for CD40 .
8103067	0	CD40	46,50	gp39	36,40	CD40	gp39	958	959	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|expression expression|nmod|END_ENTITY	The regulation of the expression of gp39 , the CD40 ligand , on normal and cloned CD4 + T cells .
16671908	0	CD40	124,128	intercellular_adhesion_molecule-1	89,122	CD40	intercellular adhesion molecule-1	958	3383	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibitory effects of Triptolide on interferon-gamma-induced human leucocyte antigen-DR , intercellular_adhesion_molecule-1 , CD40 expression on retro-ocular fibroblasts derived from patients with Graves ' _ ophthalmopathy .
11830590	0	CD40	89,93	interferon-gamma	63,79	CD40	interferon-gamma	958	3458	Gene	Gene	expression|compound|START_ENTITY role|dep|expression role|nmod|END_ENTITY	Critical role of tumor_necrosis_factor-alpha and NF-kappa_B in interferon-gamma - induced CD40 expression in microglia/macrophages .
11886848	0	CD40	0,4	interleukin-6	13,26	CD40	interleukin-6	958	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	CD40 induces interleukin-6 gene transcription in dendritic cells : regulation by TRAF2 , AP-1 , NF-kappa B , AND CBF1 .
18339606	0	CD40	106,110	myeloperoxidase	78,93	CD40	myeloperoxidase	958	4353	Gene	Gene	ligand|compound|START_ENTITY ligand|amod|END_ENTITY	Concurrent evaluation of novel cardiac biomarkers in acute_coronary_syndrome : myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic_events in TACTICS-TIMI 18 .
23617736	0	CD40	48,52	osteopontin	12,23	CD40	osteopontin	958	6696	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	The role of osteopontin in the induction of the CD40 ligand in Graves ' _ disease .
15107845	0	CD40	11,15	p38MAPK	32,39	CD40	p38MAPK	21939(Tax:10090)	26416(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Reciprocal CD40 signals through p38MAPK and ERK-1 / 2 induce counteracting immune responses .
12374738	0	CD40	0,4	p52	52,55	CD40	p52	21939(Tax:10090)	18034(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CD40 regulates the processing of NF-kappaB2_p100 to p52 .
19405121	0	CD40	21,25	p53	50,53	CD40	p53	21939(Tax:10090)	22060(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells .
8598210	0	CD40	14,18	stress-activated_protein_kinases	53,85	CD40	stress-activated protein kinases	958	5601	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cross-linking CD40 on B cells preferentially induces stress-activated_protein_kinases rather than mitogen-activated protein kinases .
11796758	0	CD40	56,60	tumor_necrosis_factor-alpha	14,41	CD40	tumor necrosis factor-alpha	958	7124	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of tumor_necrosis_factor-alpha expression by CD40 ligation in BV-2 microglial cells .
11830590	0	CD40	89,93	tumor_necrosis_factor-alpha	17,44	CD40	tumor necrosis factor-alpha	958	7124	Gene	Gene	expression|compound|START_ENTITY role|dep|expression role|nmod|END_ENTITY	Critical role of tumor_necrosis_factor-alpha and NF-kappa_B in interferon-gamma - induced CD40 expression in microglia/macrophages .
12604404	0	CD40	0,4	tumor_necrosis_factor-alpha	124,151	CD40	tumor necrosis factor-alpha	958	7124	Gene	Gene	triggering|compound|START_ENTITY enhances|nsubj|triggering enhances|nmod|release release|nmod|END_ENTITY	CD40 triggering enhances fludarabine-induced apoptosis of chronic_lymphocytic_leukemia B-cells through autocrine release of tumor_necrosis_factor-alpha and interferon-gama and tumor necrosis factor receptor-I-II upregulation .
12697681	0	CD40	0,4	tumor_necrosis_factor_alpha	40,67	CD40	tumor necrosis factor alpha	21939(Tax:10090)	21926(Tax:10090)	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|acl|induced induced|nmod|END_ENTITY	CD40 ligand blocks apoptosis induced by tumor_necrosis_factor_alpha , glucocorticoids , and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4 .
12960157	0	CD40	0,4	tumor_necrosis_factor_receptor-associated_factor_2	42,92	CD40	tumor necrosis factor receptor-associated factor 2	958	7186	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	CD40 signaling through a newly identified tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- binding site .
10799861	0	CD40	0,4	vascular_endothelial_growth_factor	66,100	CD40	vascular endothelial growth factor	958	7422	Gene	Gene	engagement|nsubj|START_ENTITY engagement|nmod|production production|nmod|END_ENTITY	CD40 engagement on synovial fibroblast up-regulates production of vascular_endothelial_growth_factor .
11090063	0	CD40	12,16	vascular_endothelial_growth_factor	43,77	CD40	vascular endothelial growth factor	958	7422	Gene	Gene	Ligation|nmod|START_ENTITY induces|nsubj|Ligation induces|dobj|expression expression|nmod|END_ENTITY	Ligation of CD40 induces the expression of vascular_endothelial_growth_factor by endothelial cells and monocytes and promotes angiogenesis in vivo .
11830495	0	CD40	0,4	vascular_endothelial_growth_factor	38,72	CD40	vascular endothelial growth factor	958	7422	Gene	Gene	activation|compound|START_ENTITY induces|nsubj|activation induces|dobj|secretion secretion|compound|END_ENTITY	CD40 activation induces p53-dependent vascular_endothelial_growth_factor secretion in human multiple_myeloma cells .
18079224	0	CD40	24,28	vascular_endothelial_growth_factor	39,73	CD40	vascular endothelial growth factor	958	7422	Gene	Gene	Relationship|nmod|START_ENTITY ligand|nsubj|Relationship ligand|nmod|END_ENTITY	Relationship of soluble CD40 ligand to vascular_endothelial_growth_factor , angiopoietins , and tissue factor in atrial_fibrillation : a link among platelet activation , angiogenesis , and thrombosis ?
20303602	0	CD40	0,4	vascular_endothelial_growth_factor	24,58	CD40	vascular endothelial growth factor	958	7422	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	CD40 is a regulator for vascular_endothelial_growth_factor in the tumor microenvironment of glioma .
11422428	0	CD40-ligand	38,49	CD154	31,36	CD40-ligand	CD154	959	959	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased T cell expression of CD154 -LRB- CD40-ligand -RRB- in multiple_sclerosis .
11127303	0	CD40L	23,28	CD154	16,21	CD40L	CD154	959	959	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The kinetics of CD154 -LRB- CD40L -RRB- expression in peripheral blood mononuclear cells of healthy subjects in liver allograft recipients and X-linked_hyper-IgM_syndrome .
17553339	0	CD40L	28,33	CD154	21,26	CD40L	CD154	959	959	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- Correlation between CD154 -LRB- CD40L -RRB- expression and naive/memory CD4 -LRB- + -RRB- T cells -RSB- .
19546834	0	CD40L	44,49	CD154	51,56	CD40L	CD154	21947(Tax:10090)	21947(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Increase of in vivo antitumoral activity by CD40L -LRB- CD154 -RRB- gene transfer into pancreatic_tumor cell-dendritic cell hybrids .
11260318	0	CD40L	132,137	CD4	84,87	CD40L	CD4	959	920	Gene	Gene	expressing|dobj|START_ENTITY undergo|xcomp|expressing undergo|dobj|cells cells|amod|apoptosis apoptosis|nmod|culture culture|nmod|killer killer|compound|END_ENTITY	Dendritic_cells rapidly undergo apoptosis in vitro following culture with activated CD4 + Valpha24 natural killer T cells expressing CD40L .
11399230	0	CD40L	44,49	CD4	119,122	CD40L	CD4	959	920	Gene	Gene	responses|nmod|START_ENTITY Modulation|nmod|responses Modulation|dep|CD40L CD40L|acl|plasmid plasmid|ccomp|enhance enhance|dobj|immunity immunity|compound|END_ENTITY	Modulation of cellular responses by plasmid CD40L : CD40L plasmid vectors enhance antigen-specific helper T cell type 1 CD4 + T cell-mediated protective immunity against herpes_simplex_virus type 2 in vivo .
11399230	0	CD40L	51,56	CD4	119,122	CD40L	CD4	959	920	Gene	Gene	START_ENTITY|acl|plasmid plasmid|ccomp|enhance enhance|dobj|immunity immunity|compound|END_ENTITY	Modulation of cellular responses by plasmid CD40L : CD40L plasmid vectors enhance antigen-specific helper T cell type 1 CD4 + T cell-mediated protective immunity against herpes_simplex_virus type 2 in vivo .
11981828	0	CD40L	84,89	CD4	78,81	CD40L	CD4	959	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ +|appos|cells +|compound|END_ENTITY	Chronic_lymphocytic_leukemia B cells are endowed with the capacity to attract CD4 + , CD40L + T cells by producing CCL22 .
12234621	0	CD40L	36,41	CD4	80,83	CD40L	CD4	959	920	Gene	Gene	expression|nummod|START_ENTITY modulates|dobj|expression modulates|parataxis|T T|nsubj|END_ENTITY	Cyclic_AMP differentially modulates CD40L expression on human nai ; ve and memory CD4 -LRB- + -RRB- T cells .
12390318	0	CD40L	63,68	CD4	72,75	CD40L	CD4	959	920	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nmod|cells cells|nummod|END_ENTITY	Ribavirin increases mitogen - and antigen-induced expression of CD40L on CD4 + T cells in vivo .
14976397	0	CD40L	8,13	CD4	46,49	CD40L	CD4	959	920	Gene	Gene	expression|compound|START_ENTITY activated|nsubj|expression activated|dobj|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Reduced CD40L expression on ex vivo activated CD4 + T-lymphocytes from patients with excellent renal allograft function measured with a rapid whole blood flow cytometry procedure .
15993419	0	CD40L	52,57	CD4	37,40	CD40L	CD4	959	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Isolation of viable antigen-specific CD4 T cells by CD40L surface trapping .
16617733	0	CD40L	1,6	CD4	23,26	CD40L	CD4	959	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	-LSB- CD40L expression on T CD4 + lymphocytes from peripheral blood in patients with relapsing-remitting and secondary progressive multiple_sclerosis -RSB- .
16815973	0	CD40L	41,46	CD4	6,9	CD40L	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival .
18838544	0	CD40L	0,5	CD4	7,10	CD40L	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	CD40L + CD4 + memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming .
21151195	0	CD40L	0,5	CD4	34,37	CD40L	CD4	959	920	Gene	Gene	cells|nummod|START_ENTITY cells|amod|co-stimulation co-stimulation|nmod|+ +|nmod|memory memory|compound|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21151195	0	CD40L	0,5	CD4	72,75	CD40L	CD4	959	920	Gene	Gene	cells|nummod|START_ENTITY supports|nsubj|cells supports|dobj|expansion expansion|nummod|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21460206	0	CD40L	97,102	CD4	104,107	CD40L	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L + CD4 + memory T cells .
22851303	0	CD40L	83,88	CD4	128,131	CD40L	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Differential modulation by delta9-tetrahydrocannabinol -LRB- 9 -RRB- - THC -RRB- of CD40 ligand -LRB- CD40L -RRB- expression in activated mouse splenic CD4 + T cells .
24117612	0	CD40L	31,36	CD4	40,43	CD40L	CD4	959	920	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|cells cells|compound|END_ENTITY	Upregulation of membrane-bound CD40L on CD4 + T cells in women with primary Sj gren 's syndrome .
9691083	0	CD40L	74,79	CD4	0,3	CD40L	CD4	959	920	Gene	Gene	ligand|dep|START_ENTITY antibody|amod|ligand tolerized|nmod|antibody T|acl:relcl|tolerized T|compound|END_ENTITY	CD4 -LRB- + -RRB- T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand -LRB- CD40L : CD154 -RRB- antibody lose their graft-versus-host_disease lethality capacity but retain nominal antigen responses .
9826442	0	CD40L	22,27	CD4	67,70	CD40L	CD4	959	920	Gene	Gene	CD154|appos|START_ENTITY TNF-alpha|appos|CD154 plays|nsubj|TNF-alpha T|ccomp|plays T|nsubj|END_ENTITY	TNF-alpha , not CD154 -LRB- CD40L -RRB- , plays a major role in SEB-dependent , CD4 -LRB- + -RRB- T cell-induced endothelial cell activation in vitro .
10201021	0	CD40L	60,65	CD40	0,4	CD40L	CD40	959	958	Gene	Gene	expression|appos|START_ENTITY expression|nummod|END_ENTITY	CD40 expression on graft infiltrates and parenchymal CD154 -LRB- CD40L -RRB- induction in human chronic renal allograft rejection .
10566730	0	CD40L	35,40	CD40	14,18	CD40L	CD40	959	958	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD40 and its ligand , CD40L , in intestinal lesions of Crohn 's _ disease .
11297035	0	CD40L	22,27	CD40	9,13	CD40L	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	Platelet CD40 ligand -LRB- CD40L -RRB- -- subcellular localization , regulation of expression , and inhibition by clopidogrel .
11817328	0	CD40L	5,10	CD40	0,4	CD40L	CD40	959	958	Gene	Gene	interactions|nummod|START_ENTITY END_ENTITY|dep|interactions	CD40 : CD40L interactions in X-linked_and_non-X-linked_hyper-IgM_syndromes .
12036894	0	CD40L	77,82	CD40	72,76	CD40L	CD40	959	958	Gene	Gene	results|nummod|START_ENTITY induction|dep|results induction|nmod|cells cells|nmod|blockade blockade|nmod|END_ENTITY	Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40 : CD40L costimulatory pathway results in the generation of a potent immune regulatory cell .
12771917	1	CD40L	147,152	CD40	76,80	CD40L	CD40	959	958	Gene	Gene	interaction|nmod|START_ENTITY apoptosis|nmod|interaction apoptosis|nsubj|Evidence Evidence|dep|undergo undergo|nsubj|cells cells|compound|END_ENTITY	Evidence that CD40 + neuroblastoma cells undergo apoptosis following interaction with CD40L .
12950679	0	CD40L	28,33	CD40	22,26	CD40L	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	IFN-gamma|nsubj|START_ENTITY IFN-gamma|nmod|expression expression|nmod|END_ENTITY	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
15623492	0	CD40L	41,46	CD40	28,32	CD40L	CD40	959	958	Gene	Gene	gene|appos|START_ENTITY gene|amod|ligand ligand|advmod|END_ENTITY	Mutational screening of the CD40 ligand -LRB- CD40L -RRB- gene in patients with X_linked_hyper-IgM_syndrome -LRB- XHIM -RRB- and determination of carrier status in female relatives .
15698512	0	CD40L	81,86	CD40	35,39	CD40L	CD40	959	958	Gene	Gene	mediated|nmod|START_ENTITY ligation|acl|mediated ligation|nummod|END_ENTITY	Differential downstream effects of CD40 ligation mediated by membrane or soluble CD40L and agonistic Ab : a study on purified human B cells .
15968400	0	CD40L	20,25	CD40	12,16	CD40L	CD40	959	958	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	The role of CD40 in CD40L - and antibody-mediated platelet activation .
16213477	0	CD40L	117,122	CD40	38,42	CD40L	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	killing|nmod|START_ENTITY induction|acl|killing expression|dep|induction expression|nmod|END_ENTITY	Constitutive expression of functional CD40 on mouse renal_cancer cells : induction of Fas and Fas-mediated killing by CD40L .
17319699	0	CD40L	46,51	CD40	66,70	CD40L	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY Cooperativity|nmod|interaction mimetics|nsubj|Cooperativity mimetics|nmod|END_ENTITY	Cooperativity in the interaction of synthetic CD40L mimetics with CD40 and its implication in cell signaling .
19734779	0	CD40L	44,49	CD40	25,29	CD40L	CD40	959	958	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Upregulation Upregulation|nmod|platelet platelet|nummod|END_ENTITY	Upregulation of platelet CD40 , CD40 ligand -LRB- CD40L -RRB- and P-Selectin expression in cigarette smokers : a flow cytometry study .
19734779	0	CD40L	44,49	CD40	31,35	CD40L	CD40	959	958	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Upregulation Upregulation|nmod|platelet platelet|nummod|END_ENTITY	Upregulation of platelet CD40 , CD40 ligand -LRB- CD40L -RRB- and P-Selectin expression in cigarette smokers : a flow cytometry study .
22561578	0	CD40L	36,41	CD40	30,34	CD40L	CD40	959	958	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Developments in the study of CD40 / CD40L gene and its polymorphism in atherosclerosis -RSB- .
22851303	0	CD40L	83,88	CD40	70,74	CD40L	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY ligand|xcomp|expression ligand|nmod|END_ENTITY	Differential modulation by delta9-tetrahydrocannabinol -LRB- 9 -RRB- - THC -RRB- of CD40 ligand -LRB- CD40L -RRB- expression in activated mouse splenic CD4 + T cells .
25908768	0	CD40L	9,14	CD40	90,94	CD40L	CD40	21947(Tax:10090)	21939(Tax:10090)	Gene	Gene	Phosphatidylinositol|compound|START_ENTITY Phosphatidylinositol|dep|END_ENTITY	Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase b , and Not Via CD40 and IkB kinase a. OBJECTIVE : To investigate the roles and signaling pathways of CD40L and CD40 in platelet-platelet interactions and thrombus formation under conditions relevant for atherothrombosis .
25992978	0	CD40L	47,52	CD40	22,26	CD40L	CD40	959	958	Gene	Gene	Cells|nmod|START_ENTITY END_ENTITY|nmod|Cells	Direct Interaction of CD40 on Tumor Cells with CD40L on T Cells Increases the Proliferation of Tumor Cells by Enhancing TGF-b Production and Th17 Differentiation .
26483316	0	CD40L	67,72	CD40	61,65	CD40L	CD40	574160(Tax:9544)	707749(Tax:9544)	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Gene expression and TB pathogenesis in rhesus_macaques : TR4 , CD40 , CD40L , FAS -LRB- CD95 -RRB- , and TNF are host genetic markers in peripheral blood mononuclear cells that are associated with severity of TB_lesions .
7532462	0	CD40L	12,17	CD40	25,29	CD40L	CD40	959	958	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of CD40L -LRB- gp39 -RRB- / CD40 in T/B cell interaction and primary immunodeficiency .
9605317	0	CD40L	63,68	CD40	87,91	CD40L	CD40	959	958	Gene	Gene	recognition|nmod|START_ENTITY role|nmod|recognition role|nmod|END_ENTITY	The role of polar interactions in the molecular recognition of CD40L with its receptor CD40 .
7916370	0	CD40L	13,18	CD40_ligand	0,11	CD40L	CD40 ligand	959	959	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CD40_ligand -LRB- CD40L -RRB- expression and B cell function in agammaglobulinemia with normal or elevated levels of IgM -LRB- HIM -RRB- .
19159577	0	CD40L	15,20	E-selectin	29,39	CD40L	E-selectin	959	6401	Gene	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|dobj|expression expression|amod|END_ENTITY	-LSB- Inhibition of CD40L induced E-selectin expression in endothelial cells through extracellular signal-regulated kinase signaling pathway -RSB- .
25787755	0	CD40L	103,108	IL-6	84,88	CD40L	IL-6	959	3569	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells .
19821826	0	CD40L	21,26	IRF4	0,4	CD40L	IRF4	959	3662	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin_lymphoma .
26986513	0	CD40L	35,40	NORE1A	0,6	CD40L	NORE1A	959	83593	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	NORE1A induction by membrane-bound CD40L -LRB- mCD40L -RRB- contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism .
26706786	0	CD40L	39,44	VEGF	22,26	CD40L	VEGF	959	7422	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Diagnostic utility of VEGF and soluble CD40L levels in serum of Alzheimer 's patients .
7554469	0	CD40L	18,23	gp39	12,16	CD40L	gp39	959	959	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of gp39 -LRB- CD40L -RRB- in immunity .
26934129	0	CD40L	8,13	insulin	33,40	CD40L	insulin	959	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Soluble CD40L is associated with insulin resistance , but not with glucose tolerance in obese nondiabetic patients .
26986513	0	CD40L	35,40	mCD40L	42,48	CD40L	mCD40L	959	21947(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	NORE1A induction by membrane-bound CD40L -LRB- mCD40L -RRB- contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism .
18269829	0	CD40L	27,32	vascular_cell_adhesion_molecule-1	41,74	CD40L	vascular cell adhesion molecule-1	959	7412	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	-LSB- Simvastatin downregulates CD40L induced vascular_cell_adhesion_molecule-1 expression and adhesive function in human umbilical vein endothelial cells -RSB- .
10201926	0	CD40_ligand	21,32	CD154	14,19	CD40 ligand	CD154	959	959	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of CD154 -LRB- CD40_ligand -RRB- mRNA stability during T cell activation .
10929069	0	CD40_ligand	31,42	CD154	24,29	CD40 ligand	CD154	959	959	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of functional CD154 -LRB- CD40_ligand -RRB- in neonatal T cells by cAMP-elevating agents .
11529914	0	CD40_ligand	50,61	CD154	43,48	CD40 ligand	CD154	959	959	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	NF-kappaB is involved in the regulation of CD154 -LRB- CD40_ligand -RRB- expression in primary human T cells .
14607202	0	CD40_ligand	26,37	CD154	19,24	CD40 ligand	CD154	959	959	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Enhanced levels of CD154 -LRB- CD40_ligand -RRB- on platelets in patients with chronic_heart_failure .
18640985	0	CD40_ligand	74,85	CD154	67,72	CD40 ligand	CD154	21947(Tax:10090)	21947(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Separate cis-trans pathways post-transcriptionally regulate murine CD154 -LRB- CD40_ligand -RRB- expression : a novel function for CA repeats in the 3 ' - untranslated region .
11160303	0	CD40_ligand	49,60	CD28	20,24	CD40 ligand	CD28	959	940	Gene	Gene	promoter|amod|START_ENTITY Identification|nmod|promoter Identification|nmod|element element|compound|END_ENTITY	Identification of a CD28 response element in the CD40_ligand promoter .
15067037	0	CD40_ligand	18,29	CD28	57,61	CD40 ligand	CD28	959	940	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	The modulation of CD40_ligand signaling by transmembrane CD28 splice variant in human T cells .
10949194	0	CD40_ligand	11,22	CD4	53,56	CD40 ligand	CD4	959	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Heightened CD40_ligand gene expression in peripheral CD4 + T cells from patients with kidney allograft rejection .
11401990	0	CD40_ligand	113,124	CD4	128,131	CD40 ligand	CD4	959	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Distinct cytokine regulation by cholera toxin and type II heat-labile toxins involves differential regulation of CD40_ligand on CD4 -LRB- + -RRB- T cells .
12563087	0	CD40_ligand	14,25	CD4	29,32	CD40 ligand	CD4	959	920	Gene	Gene	START_ENTITY|nmod|T-cells T-cells|compound|END_ENTITY	Expression of CD40_ligand on CD4 + T-cells and platelets correlated to the coronary_artery_lesion and disease progress in Kawasaki_disease .
14517846	0	CD40_ligand	0,11	CD4	40,43	CD40 ligand	CD4	959	920	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	CD40_ligand is selectively expressed on CD4 + T cells and platelets : implications for CD40-CD40L signalling in atherosclerosis .
17595332	0	CD40_ligand	10,21	CD4	75,78	CD40 ligand	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	exists|nsubj|START_ENTITY exists|dobj|cells cells|nummod|+ +|compound|END_ENTITY	Preformed CD40_ligand exists in secretory lysosomes in effector and memory CD4 + T cells and is quickly expressed on the cell surface in an antigen-specific manner .
23999542	0	CD40_ligand	65,76	CD4	127,130	CD40 ligand	CD4	959	920	Gene	Gene	expression|amod|START_ENTITY suppression|nmod|expression involved|nmod|suppression involved|dobj|cells cells|amod|tetrahydrocannabinol tetrahydrocannabinol|nmod|T T|compound|END_ENTITY	Impaired NFAT and NFkB activation are involved in suppression of CD40_ligand expression by / \ -LRB- 9 -RRB- - tetrahydrocannabinol in human CD4 -LRB- + -RRB- T cells .
8617933	0	CD40_ligand	21,32	CD4	42,45	CD40 ligand	CD4	959	920	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Cross-linking of the CD40_ligand on human CD4 + T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis .
8671613	0	CD40_ligand	14,25	CD4	46,49	CD40 ligand	CD4	21947(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Regulation of CD40_ligand expression on naive CD4 T cells : a role for TCR but not co-stimulatory signals .
16904975	0	CD40_ligand	0,11	CD40	49,53	CD40 ligand	CD40	959	958	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	CD40_ligand increases expression of its receptor CD40 in human coronary artery endothelial cells .
7916370	0	CD40_ligand	0,11	CD40L	13,18	CD40 ligand	CD40L	959	959	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD40_ligand -LRB- CD40L -RRB- expression and B cell function in agammaglobulinemia with normal or elevated levels of IgM -LRB- HIM -RRB- .
16971806	0	CD40_ligand	53,64	CD8	71,74	CD40 ligand	CD8	959	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Blood dendritic cells generated with Flt3_ligand and CD40_ligand prime CD8 + T cells efficiently in cancer patients .
10369418	0	CD40_ligand	62,73	Cgamma1	42,49	CD40 ligand	Cgamma1	21947(Tax:10090)	107573(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the germline immunoglobulin Cgamma1 promoter by CD40_ligand and IL-4 : dual role for tandem NF-kappaB binding sites .
9192766	0	CD40_ligand	35,46	Interleukin-13	0,14	CD40 ligand	Interleukin-13	959	3596	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interleukin-13 in combination with CD40_ligand potently inhibits apoptosis in human B lymphocytes : upregulation of Bcl-xL and Mcl-1 .
18641098	0	CD40_ligand	8,19	P-selectin	130,140	CD40 ligand	P-selectin	959	6403	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Soluble CD40_ligand , platelet surface CD40_ligand , and total platelet CD40_ligand in atrial_fibrillation : relationship to soluble P-selectin , stroke risk factors , and risk factor intervention .
8671613	0	CD40_ligand	14,25	TCR	70,73	CD40 ligand	TCR	21947(Tax:10090)	328483(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of CD40_ligand expression on naive CD4 T cells : a role for TCR but not co-stimulatory signals .
7615003	0	CD40_ligand	24,35	TRAP	18,22	CD40 ligand	TRAP	959	100187907	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	A soluble form of TRAP -LRB- CD40_ligand -RRB- is rapidly released after T cell activation .
10820273	0	CD40_ligand	0,11	Th1	33,36	CD40 ligand	Th1	959	51497	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	CD40_ligand -LRB- CD154 -RRB- enhances the Th1 and antibody responses to respiratory_syncytial_virus in the BALB/c mouse .
19282610	0	CD40_ligand	58,69	adiponectin	34,45	CD40 ligand	adiponectin	959	9370	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Effect of cilostazol treatment on adiponectin and soluble CD40_ligand levels in diabetic patients with peripheral arterial_occlusion_disease .
17953526	0	CD40_ligand	33,44	calreticulin	15,27	CD40 ligand	calreticulin	959	811	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of calreticulin with CD40_ligand , TRAIL and Fas_ligand .
10195569	0	CD41	67,71	CD34	62,66	CD41	CD34	3674	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cytokine-induced expansion of human CD34 + stem/progenitor and CD34 + CD41 + early megakaryocytic marrow cells cultured on normal osteoblasts .
10663616	0	CD41	27,31	CD34	21,25	CD41	CD34	3674	947	Gene	Gene	+|compound|START_ENTITY progenitors|nsubj|+ expansion|parataxis|progenitors expansion|nmod|+ +|compound|END_ENTITY	Ex vivo expansion of CD34 + / CD41 + late progenitors from enriched peripheral blood CD34 + cells .
10663616	0	CD41	27,31	CD34	81,85	CD41	CD34	3674	947	Gene	Gene	+|compound|START_ENTITY progenitors|nsubj|+ progenitors|nmod|cells cells|compound|END_ENTITY	Ex vivo expansion of CD34 + / CD41 + late progenitors from enriched peripheral blood CD34 + cells .
11983103	0	CD41	77,81	CD34	72,76	CD41	CD34	3674	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Correlation of time to platelet engraftment with amount of transplanted CD34 + CD41 + cells after allogeneic bone marrow transplantation .
8641347	0	CD41	23,27	CD34	18,22	CD41	CD34	3674	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Fetal bone marrow CD34 + CD41 + cells are enriched for multipotent hematopoietic progenitors , but not for pluripotent stem cells .
9808053	0	CD41	28,32	CD34	22,26	CD41	CD34	3674	947	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ CD41|dep|cells CD41|compound|END_ENTITY	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
9808053	0	CD41	28,32	CD34	68,72	CD41	CD34	3674	947	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|nmod|+ +|compound|END_ENTITY	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
9808053	0	CD41	74,78	CD34	68,72	CD41	CD34	3674	947	Gene	Gene	START_ENTITY|dep|cells cells|nmod|+ +|compound|END_ENTITY	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
9808053	0	CD41	28,32	CD41	74,78	CD41	CD41	3674	3674	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|dep|cells	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
9808053	0	CD41	74,78	CD41	28,32	CD41	CD41	3674	3674	Gene	Gene	START_ENTITY|dep|cells cells|nummod|+ +|compound|END_ENTITY	In vitro expansion of CD34 + / CD41 + cells from human peripheral blood CD34 + / CD41 - cells : role of cytokines for in vitro proliferation and differentiation of megakaryocytic progenitors .
18252864	0	CD41	49,53	c-kit	54,59	CD41	c-kit	16399(Tax:10090)	16590(Tax:10090)	Gene	Gene	progenitors|compound|START_ENTITY progenitors|amod|END_ENTITY	Modulation of murine embryonic stem cell-derived CD41 + c-kit + hematopoietic progenitors by ectopic expression of Cdx genes .
2968928	2	CD43	102,106	CALLA	114,119	CD43	CALLA	6693	4311	Gene	Gene	CD10|compound|START_ENTITY CD10|appos|END_ENTITY	Antibodies against CD45 -LRB- T200 -RRB- , CD3 -LRB- T3 -RRB- , CD43 , CD10 -LRB- CALLA -RRB- , transferrin receptor -LRB- T9 -RRB- , a novel broadly expressed 18-kDa antigen -LRB- MEM-43 -RRB- and a novel antigen of restricted expression -LRB- MEM-74 -RRB- .
23911852	0	CD43	157,161	CD19	117,121	CD43	CD19	6693	930	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
21220451	0	CD43	100,104	CD20	88,92	CD43	CD20	6693	54474	Gene	Gene	CD70|compound|START_ENTITY CD70|compound|END_ENTITY	Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 + CD27 + CD43 + CD70 - .
23911852	0	CD43	157,161	CD20	124,128	CD43	CD20	6693	54474	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
21220451	0	CD43	100,104	CD27	94,98	CD43	CD27	6693	939	Gene	Gene	CD70|compound|START_ENTITY CD70|compound|END_ENTITY	Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20 + CD27 + CD43 + CD70 - .
23911852	0	CD43	157,161	CD27	144,148	CD43	CD27	6693	939	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
7790813	0	CD43	0,4	CD28	79,83	CD43	CD28	20737(Tax:10090)	12487(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	CD43 is a murine T cell costimulatory receptor that functions independently of CD28 .
10069424	0	CD43	31,35	CD4	95,98	CD43	CD4	6693	920	Gene	Gene	O-glycans|nmod|START_ENTITY expressed|nsubjpass|O-glycans expressed|nmod|subset subset|nmod|cells cells|compound|END_ENTITY	Core 2-containing O-glycans on CD43 are preferentially expressed in the memory subset of human CD4 T cells .
11110701	0	CD43	45,49	CD4	63,66	CD43	CD4	20737(Tax:10090)	12504(Tax:10090)	Gene	Gene	glycoform|nmod|START_ENTITY function|nmod|glycoform expressed|nsubj|function expressed|nmod|clones clones|nummod|END_ENTITY	Antiadhesive function of 130-kd glycoform of CD43 expressed in CD4 T-lymphocyte clones and transfectant cell lines .
15187099	0	CD43	131,135	CD4	70,73	CD43	CD4	6693	920	Gene	Gene	using|nmod|START_ENTITY analysis|acl|using characteristics|dep|analysis characteristics|nmod|CD43 CD43|nmod|cells cells|compound|END_ENTITY	Expression characteristics and stimulatory functions of CD43 in human CD4 + memory T cells : analysis using a monoclonal antibody to CD43 that has a novel lineage specificity .
15187099	0	CD43	56,60	CD4	70,73	CD43	CD4	6693	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression characteristics and stimulatory functions of CD43 in human CD4 + memory T cells : analysis using a monoclonal antibody to CD43 that has a novel lineage specificity .
15668924	0	CD43	43,47	CD4	66,69	CD43	CD4	20737(Tax:10090)	12504(Tax:10090)	Gene	Gene	changes|nmod|START_ENTITY changes|nmod|cells cells|compound|END_ENTITY	Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells .
16500623	0	CD43	24,28	CD4	30,33	CD43	CD4	20737(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Upregulation of ICOS on CD43 + CD4 + murine small intestinal intraepithelial lymphocytes during acute reovirus_infection .
17638845	0	CD43	18,22	CD4	33,36	CD43	CD4	20737(Tax:10090)	12504(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nsubj|trafficking trafficking|nummod|END_ENTITY	Signaling through CD43 regulates CD4 T-cell trafficking .
18036228	0	CD43	0,4	CD4	57,60	CD43	CD4	6693	920	Gene	Gene	signals|nsubj|START_ENTITY signals|xcomp|induce induce|dobj|commitment commitment|nmod|cells cells|compound|END_ENTITY	CD43 signals induce Type One lineage commitment of human CD4 + T cells .
20070216	0	CD43	43,47	CD4	7,10	CD43	CD4	6693	920	Gene	Gene	level|compound|START_ENTITY discriminated|nmod|level discriminated|nsubj|subsets subsets|compound|END_ENTITY	Memory CD4 T-cell subsets discriminated by CD43 expression level in A-bomb survivors .
7537557	0	CD43	27,31	CD4	46,49	CD43	CD4	20737(Tax:10090)	12504(Tax:10090)	Gene	Gene	glycoforms|nummod|START_ENTITY glycoforms|nmod|+ +|compound|END_ENTITY	Differential regulation of CD43 glycoforms on CD4 + and CD8 + T lymphocytes in graft-versus-host_disease .
8554898	0	CD43	113,117	CD4	69,72	CD43	CD4	6693	920	Gene	Gene	deficient|nmod|START_ENTITY lymphocytes|xcomp|deficient lymphocytes|nsubj|T T|amod|Enhanced Enhanced|xcomp|human_immunodeficiency_virus_infection human_immunodeficiency_virus_infection|nmod|END_ENTITY	Enhanced susceptibility to human_immunodeficiency_virus_infection in CD4 + T lymphocytes genetically deficient in CD43 .
8778031	0	CD43	34,38	CD4	113,116	CD43	CD4	6693	920	Gene	Gene	expression|nmod|START_ENTITY pattern|nmod|expression subsets|nsubj|pattern subsets|nmod|+ +|compound|END_ENTITY	Parallel pattern of expression of CD43 and of LFA-1 on the CD45RA + -LRB- naive -RRB- and CD45RO + -LRB- memory -RRB- subsets of human CD4 + and CD8 + cells .
19726877	0	CD43	128,132	CD45	133,137	CD43	CD45	6693	5788	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34 + CD43 + CD45 + progenitors .
23911852	0	CD43	157,161	CD70	137,141	CD43	CD70	6693	970	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
16339541	0	CD43	0,4	E-Selectin	31,41	CD43	E-Selectin	20737(Tax:10090)	20339(Tax:10090)	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	CD43 functions as a ligand for E-Selectin on activated T cells .
17392823	0	CD43	25,29	E-selectin	46,56	CD43	E-selectin	20737(Tax:10090)	20339(Tax:10090)	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type_hypersensitivity reactions in vivo .
17015718	0	CD43	27,31	Galectin-1	0,10	CD43	Galectin-1	20737(Tax:10090)	16852(Tax:10090)	Gene	Gene	glycoforms|compound|START_ENTITY binds|dobj|glycoforms binds|nsubj|END_ENTITY	Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death .
17015718	0	CD43	54,58	Galectin-1	0,10	CD43	Galectin-1	20737(Tax:10090)	16852(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death .
1683685	0	CD43	0,4	ICAM-1	62,68	CD43	ICAM-1	6693	3383	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	CD43 , a molecule defective in Wiskott-Aldrich_syndrome , binds ICAM-1 .
19662219	0	CD43	72,76	ICAM-1	65,71	CD43	ICAM-1	6693	3383	Gene	Gene	Interaction|compound|START_ENTITY Interaction|compound|END_ENTITY	Induction of Proteases_in_Peritoneal_Carcinomatosis , the Role of ICAM-1 / CD43 Interaction .
16500623	0	CD43	24,28	ICOS	16,20	CD43	ICOS	20737(Tax:10090)	54167(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Upregulation of ICOS on CD43 + CD4 + murine small intestinal intraepithelial lymphocytes during acute reovirus_infection .
17277158	0	CD43	0,4	P-selectin_glycoprotein_ligand-1	23,55	CD43	P-selectin glycoprotein ligand-1	20737(Tax:10090)	20345(Tax:10090)	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	CD43 collaborates with P-selectin_glycoprotein_ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin .
22576689	0	CD43	17,21	b-catenin	64,73	CD43	b-catenin	6693	1499	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Leukocyte marker CD43 promotes cell growth in co-operation with b-catenin in non-hematopoietic_cancer cells .
7768930	0	CD43	65,69	leukosialin	52,63	CD43	leukosialin	6693	105369261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Tissue-specific transcriptional regulation of human leukosialin -LRB- CD43 -RRB- gene is achieved by DNA methylation .
8055899	0	CD43	49,53	leukosialin	36,47	CD43	leukosialin	6693	105369261	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of human leukosialin -LRB- CD43 -RRB- gene by Sp1 through binding to a GGGTGG motif .
11728332	0	CD43	13,17	moesin	129,135	CD43	moesin	6693	4478	Gene	Gene	Exclusion|nmod|START_ENTITY mediated|nsubjpass|Exclusion mediated|nmod|relocation relocation|nmod|END_ENTITY	Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin .
9616160	0	CD43	0,4	moesin	20,26	CD43	moesin	6693	4478	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts .
21947346	0	CD43	73,77	p53	17,20	CD43	p53	6693	7157	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic_tumor cells .
2241892	0	CD43	36,40	sialophorin	23,34	CD43	sialophorin	6693	6693	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the human sialophorin -LRB- CD43 -RRB- gene .
8157205	0	CD43	33,37	sialophorin	20,31	CD43	sialophorin	6693	6693	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human sialophorin -LRB- CD43 -RRB- in a human x mouse somatic cell hybrid .
21062915	0	CD44	131,135	ALDH1	138,143	CD44	ALDH1	960	216	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Cucurbitacin_I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous_carcinoma -- derived CD44 -LRB- + -RRB- ALDH1 -LRB- + -RRB- cells .
24519209	0	CD44	91,95	ALDH1	0,5	CD44	ALDH1	960	216	Gene	Gene	+|compound|START_ENTITY phenotype|nsubj|+ indicator|advcl|phenotype indicator|nsubj|END_ENTITY	ALDH1 is a better clinical indicator for relapse of invasive_ductal_breast_cancer than the CD44 + / CD24 - phenotype .
24716927	0	CD44	26,30	ALDH1	0,5	CD44	ALDH1	960	216	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	ALDH1 in combination with CD44 as putative_cancer stem cell markers are correlated with poor prognosis in urothelial_carcinoma of the urinary_bladder .
26298632	0	CD44	61,65	ALDH1	74,79	CD44	ALDH1	960	216	Gene	Gene	expressions|appos|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
26399460	0	CD44	0,4	ALDH1	12,17	CD44	ALDH1	960	216	Gene	Gene	START_ENTITY|dep|characteristics characteristics|nummod|END_ENTITY	CD44 -LRB- high -RRB- / ALDH1 -LRB- high -RRB- head_and_neck_squamous_cell_carcinoma cells exhibit mesenchymal characteristics and GSK3b-dependent cancer stem cell properties .
15452148	0	CD44	0,4	BMP-7	39,44	CD44	BMP-7	960	655	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	CD44 modulates Smad1 activation in the BMP-7 signaling pathway .
19385591	0	CD44	0,4	Bcl-2	71,76	CD44	Bcl-2	960	596	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|levels levels|nmod|END_ENTITY	CD44 + cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast_tumours .
8652389	0	CD44	58,62	CD11c	86,91	CD44	CD11c	960	3687	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	An aggressive subtype of B-CLL is characterized by strong CD44 expression and lack of CD11c .
19024325	0	CD44	89,93	CD133	76,81	CD44	CD133	960	8842	Gene	Gene	immunophenotype|nummod|START_ENTITY immunophenotype|nummod|END_ENTITY	-LSB- Multiparametric flow cytometry analyzes the expressions of immunophenotype CD133 , CD34 , CD44 in lung_cancer naive cells -RSB- .
19711346	0	CD44	58,62	CD133	52,57	CD44	CD133	960	8842	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Cancer stem/progenitor cells are highly enriched in CD133 + CD44 + population in hepatocellular_carcinoma .
20526812	0	CD44	7,11	CD133	0,5	CD44	CD133	960	8842	Gene	Gene	subgroups|compound|START_ENTITY subgroups|compound|END_ENTITY	CD133 + CD44 + subgroups may be human small intestinal stem cells .
20937222	0	CD44	53,57	CD133	47,52	CD44	CD133	960	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The study of the tumor stem cell properties of CD133 + CD44 + cells in the human lung_adenocarcinoma cell line A549 .
20948317	0	CD44	0,4	CD133	6,11	CD44	CD133	960	8842	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CD44 + CD133 + population exhibits cancer stem cell-like characteristics in human gallbladder_carcinoma .
21750907	0	CD44	24,28	CD133	53,58	CD44	CD133	960	8842	Gene	Gene	START_ENTITY|nmod|CD44 CD44|compound|END_ENTITY	Highly enriched CD133 -LRB- + -RRB- CD44 -LRB- + -RRB- stem-like cells with CD133 -LRB- + -RRB- CD44 -LRB- high -RRB- metastatic subset in HCT116 colon_cancer cells .
21750907	0	CD44	61,65	CD133	16,21	CD44	CD133	960	8842	Gene	Gene	CD44|nmod|START_ENTITY CD44|nsubj|END_ENTITY	Highly enriched CD133 -LRB- + -RRB- CD44 -LRB- + -RRB- stem-like cells with CD133 -LRB- + -RRB- CD44 -LRB- high -RRB- metastatic subset in HCT116 colon_cancer cells .
22740326	0	CD44	26,30	CD133	17,22	CD44	CD133	960	8842	Gene	Gene	+|compound|START_ENTITY Co-expression|dep|+ Co-expression|nmod|END_ENTITY	Co-expression of CD133 -LRB- + -RRB- / CD44 -LRB- + -RRB- in human colon_cancer and liver metastasis .
23036582	0	CD44	9,13	CD133	0,5	CD44	CD133	960	8842	Gene	Gene	isolated|parataxis|START_ENTITY isolated|nsubj|END_ENTITY	CD133 -LRB- + -RRB- / CD44 -LRB- + -RRB- / Oct4 -LRB- + -RRB- / Nestin -LRB- + -RRB- stem-like cells isolated from Panc-1 cell line may contribute to multi-resistance and metastasis of pancreatic_cancer .
23197865	0	CD44	14,18	CD133	0,5	CD44	CD133	960	8842	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
23252868	0	CD44	61,65	CD133	54,59	CD44	CD133	960	8842	Gene	Gene	ALDH1|dep|START_ENTITY ALDH1|nummod|END_ENTITY	Expression of the potential cancer stem cell markers , CD133 , CD44 , ALDH1 , and b-catenin , in primary lung_adenocarcinoma -- their prognostic significance .
23811539	0	CD44	51,55	CD133	42,47	CD44	CD133	960	8842	Gene	Gene	subpopulation|amod|START_ENTITY END_ENTITY|dep|subpopulation	Fibronectin extra_domain_A -LRB- EDA -RRB- sustains CD133 -LRB- + -RRB- / CD44 -LRB- + -RRB- subpopulation of colorectal_cancer cells .
24178866	0	CD44	0,4	CD133	6,11	CD44	CD133	960	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD44 + / CD133 + immunophenotype and matrix_metalloproteinase-9 : Influence on prognosis in early-stage oral_squamous_cell_carcinoma .
24760019	0	CD44	46,50	CD133	39,44	CD44	CD133	960	8842	Gene	Gene	CD24|appos|START_ENTITY CD24|compound|END_ENTITY	Evaluation of cancer stem cell markers CD133 , CD44 , CD24 : association with AKT isoforms and radiation resistance in colon_cancer cells .
24932297	0	CD44	90,94	CD133	78,83	CD44	CD133	960	8842	Gene	Gene	prostate_cancer|nsubj|START_ENTITY profiling|parataxis|prostate_cancer profiling|nmod|cell cell|acl|signaling signaling|nmod|formation formation|nmod|END_ENTITY	Expression profiling of stem cell signaling alters with spheroid formation in CD133 -LRB- high -RRB- / CD44 -LRB- high -RRB- prostate_cancer stem cells .
26298632	0	CD44	61,65	CD133	67,72	CD44	CD133	960	8842	Gene	Gene	expressions|appos|START_ENTITY expressions|appos|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
26318819	0	CD44	119,123	CD133	112,117	CD44	CD133	12505(Tax:10090)	19126(Tax:10090)	Gene	Gene	EpCAM|dep|START_ENTITY EpCAM|dep|END_ENTITY	LNA aptamer based multi-modal , Fe3O4-saturated_lactoferrin -LRB- Fe3O4-bLf -RRB- nanocarriers for triple positive -LRB- EpCAM , CD133 , CD44 -RRB- colon_tumor targeting and NIR , MRI and CT imaging .
23197865	0	CD44	14,18	CD166	8,13	CD44	CD166	960	214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
15709183	0	CD44	14,18	CD24	20,24	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Prevalence of CD44 + / CD24 - / low cells in breast_cancer may not be associated with clinical outcome but may favor distant metastasis .
17062128	0	CD44	0,4	CD24	6,10	CD44	CD24	12505(Tax:10090)	12484(Tax:10090)	Gene	Gene	+|compound|START_ENTITY properties|nummod|+ properties|dep|END_ENTITY	CD44 + / CD24 - breast_cancer cells exhibit enhanced invasive properties : an early step necessary for metastasis .
17179479	0	CD44	28,32	CD24	16,20	CD44	CD24	960	100133941	Gene	Gene	cells|nummod|START_ENTITY response|dep|cells response|nmod|END_ENTITY	The response of CD24 -LRB- - / low -RRB- / CD44 + breast_cancer-initiating cells to radiation .
18495204	0	CD44	53,57	CD24	81,85	CD44	CD24	960	100133941	Gene	Gene	CD24|compound|START_ENTITY significance|nmod|CD24 significance|dep|cells cells|nummod|END_ENTITY	The clinicopathologic and prognostic significance of CD44 + / CD24 -LRB- - / low -RRB- and CD44 - / CD24 + tumor cells in invasive breast_carcinomas .
18559090	0	CD44	4,8	CD24	10,14	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	The CD44 + / CD24 - phenotype is enriched in basal-like breast_tumors .
18931706	0	CD44	58,62	CD24	64,68	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	-LSB- Pilot study on the correlation between high incidence of CD44 + / CD24 - / low/ABCG2 - cells and poor prognosis in breast_cancer -RSB- .
18931707	0	CD44	14,18	CD24	20,24	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	-LSB- Isolation of CD44 + / CD24 - / low and side population cells from MDA-MB-453 cells and the analysis of their activation of Wnt and Notch pathway -RSB- .
19048252	0	CD44	49,53	CD24	55,59	CD44	CD24	960	100133941	Gene	Gene	lo|compound|START_ENTITY lo|compound|END_ENTITY	Breast_cancer cells expressing stem cell markers CD44 + CD24 lo are eliminated by Numb-1 peptide-activated T cells .
19288016	0	CD44	58,62	CD24	64,68	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY Role|nmod|+ Role|dep|END_ENTITY	Role of CCL5 in invasion , proliferation and proportion of CD44 + / CD24 - phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast_cancer progression .
19794958	0	CD44	40,44	CD24	48,52	CD44	CD24	960	100133941	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Tumor-endothelial interaction links the CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- phenotype with poor prognosis in early-stage_breast_cancer .
20004947	0	CD44	13,17	CD24	21,25	CD44	CD24	960	100133941	Gene	Gene	Reduction|nmod|START_ENTITY Reduction|parataxis|breast_cancer breast_cancer|nsubj|END_ENTITY	Reduction of CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- breast_cancer cells by conventional cytotoxic chemotherapy .
20043317	0	CD44	8,12	CD24	16,20	CD44	CD24	960	100133941	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	ALDH -LRB- + -RRB- / CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- expression in cells from body cavity fluids .
20199686	0	CD44	40,44	CD24	46,50	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY regain|nmod|+ regain|parataxis|END_ENTITY	Selective regain of egfr gene copies in CD44 + / CD24 - / low breast_cancer cellular model MDA-MB-468 .
20377923	0	CD44	43,47	CD24	49,53	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Radiation resistance in breast_cancer : are CD44 + / CD24 - / proteosome low/PKH26 + cells to blame ?
20405247	0	CD44	4,8	CD24	10,14	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	The CD44 + / CD24 - phenotype relates to ` triple-negative ' state and unfavorable prognosis in breast_cancer patients .
20569497	0	CD44	60,64	CD24	65,69	CD44	CD24	960	100133941	Gene	Gene	CXCR4|compound|START_ENTITY CXCR4|compound|END_ENTITY	Breast_cancer stromal fibroblasts promote the generation of CD44 + CD24 - cells through SDF-1 / CXCR4 interaction .
20691079	0	CD44	64,68	CD24	70,74	CD44	CD24	960	100133941	Gene	Gene	phenotype|compound|START_ENTITY phenotype|dep|END_ENTITY	SLUG/SNAI2 and tumor_necrosis_factor generate breast cells with CD44 + / CD24 - phenotype .
20977976	0	CD44	40,44	CD24	46,50	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	The clinicopathological significance of CD44 + / CD24 - / low and CD24 + tumor cells in invasive micropapillary_carcinoma_of_the_breast .
21044318	0	CD44	11,15	CD24	17,21	CD44	CD24	960	100133941	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|nummod|END_ENTITY	Increasing CD44 + / CD24 -LRB- - -RRB- tumor stem cells , and upregulation of COX-2 and HDAC6 , as major functions of HER2 in breast tumorigenesis .
21299347	0	CD44	0,4	CD24	8,12	CD44	CD24	960	100133941	Gene	Gene	progenitors|nsubj|START_ENTITY progenitors|nsubj|cells cells|compound|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- cells are transit progenitors and do not determine the molecular subtypes and clinical parameters in breast_carcinomas .
21444368	0	CD44	34,38	CD24	42,46	CD44	CD24	960	100133941	Gene	Gene	/|compound|START_ENTITY radioresistance|nmod|/ cells|amod|radioresistance cells|compound|END_ENTITY	STAT1 promotes radioresistance of CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- cells in breast_cancer .
21503107	0	CD44	121,125	CD24	128,132	CD44	CD24	960	100133941	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Dendritic cells infected by recombinant adeno-associated virus with CEA gene to induce antigen-specific CTL response to CD44 -LRB- + -RRB- CD24 -LRB- - / low -RRB- cells from MCF-7 breast_cancer cell line -RSB- .
21835433	0	CD44	0,4	CD24	8,12	CD44	CD24	960	100133941	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- cancer stem/progenitor cells are more abundant in triple-negative invasive breast_carcinoma phenotype and are associated with poor outcome .
21838786	0	CD44	32,36	CD24	41,45	CD44	CD24	960	100133941	Gene	Gene	/|compound|START_ENTITY evaluation|nmod|/ END_ENTITY|nsubj|evaluation	Semi-quantitative evaluation of CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- tumor cell distribution in breast_cancer tissue using a newly developed fluorescence immunohistochemical staining method .
21882047	0	CD44	18,22	CD24	23,27	CD44	CD24	12505(Tax:10090)	12484(Tax:10090)	Gene	Gene	gastric_cancer|compound|START_ENTITY gastric_cancer|compound|END_ENTITY	Identification of CD44 + CD24 + gastric_cancer stem cells .
21935375	0	CD44	39,43	CD24	45,49	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY resistance|nmod|+ resistance|parataxis|mediated mediated|nsubjpass|cells cells|amod|END_ENTITY	The phenotypic radiation resistance of CD44 + / CD24 -LRB- - or low -RRB- breast_cancer cells is mediated through the enhanced activation of ATM signaling .
22031797	0	CD44	4,8	CD24	10,14	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Can CD44 + / CD24 - Tumor Cells Be Used to Determine the Extent of Breast_Cancer_Invasion Following Neoadjuvant Chemotherapy ?
22119938	0	CD44	2,6	CD24	10,14	CD44	CD24	960	100133941	Gene	Gene	START_ENTITY|parataxis|marker marker|nsubj|phenotype phenotype|compound|END_ENTITY	A CD44 / CD24 phenotype is a poor prognostic marker in early invasive breast_cancer .
22322379	0	CD44	55,59	CD24	50,54	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Epithelial mesenchymal transition correlates with CD24 + CD44 + and CD133 + cells in pancreatic_cancer .
22702496	0	CD44	25,29	CD24	31,35	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY implications|nmod|+ implications|dep|END_ENTITY	Clinical implications of CD44 + / CD24 - tumor cell ratio in breast_cancer .
22762532	0	CD44	0,4	CD24	6,10	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	CD44 + / CD24 - phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive_ductal_carcinoma .
22771536	0	CD44	30,34	CD24	36,40	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|dep|END_ENTITY	Highly sensitive profiling of CD44 + / CD24 - breast_cancer stem cells by combining global mRNA amplification and next generation sequencing : evidence for a hyperactive PI3K pathway .
22855175	0	CD44	0,4	CD24	6,10	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	CD44 + / CD24 - breast_cancer cells isolated from MCF-7 cultures exhibit enhanced angiogenic properties .
23028444	0	CD44	26,30	CD24	32,36	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY identification|nmod|+ END_ENTITY|nmod|identification	In situ identification of CD44 + / CD24 - cancer cells in primary human breast_carcinomas .
23197865	0	CD44	30,34	CD24	25,29	CD44	CD24	960	100133941	Gene	Gene	phenotypes|compound|START_ENTITY phenotypes|nummod|+ +|compound|END_ENTITY	CD133 + , CD166 + CD44 + , and CD24 + CD44 + phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal_cancer cell lines .
23346166	0	CD44	44,48	CD24	52,56	CD44	CD24	960	100133941	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of bFGF on the MCF-7 Cell Cycle with CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- : Promoting the G0/G1 > G2/S Transition .
23589132	0	CD44	12,16	CD24	18,22	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Response of CD44 + / CD24 - / low breast_cancer stem/progenitor cells to tamoxifen - and doxorubicin - induced autophagy .
24167614	0	CD44	88,92	CD24	102,106	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|advmod|low low|nmod|+ +|compound|END_ENTITY	Triple_negative_breast_tumors in African-American and Hispanic/Latina women are high in CD44 + , low in CD24 + , and have loss of PTEN .
24366074	0	CD44	12,16	CD24	18,22	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	The role of CD44 + / CD24 - / low biomarker for screening , diagnosis and monitoring of breast_cancer .
24376586	0	CD44	49,53	CD24	55,59	CD44	CD24	12505(Tax:10090)	12484(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Evaluation of STAT3 signaling in ALDH + and ALDH + / CD44 + / CD24 - subpopulations of breast_cancer cells .
24519209	0	CD44	91,95	CD24	97,101	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	ALDH1 is a better clinical indicator for relapse of invasive_ductal_breast_cancer than the CD44 + / CD24 - phenotype .
25130168	0	CD44	9,13	CD24	17,21	CD44	CD24	960	100133941	Gene	Gene	drives|nsubj|START_ENTITY drives|nmod|population population|compound|END_ENTITY	Enriched CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- population drives the aggressive phenotypes presented in triple-negative breast_cancer -LRB- TNBC -RRB- .
25541438	0	CD44	93,97	CD24	101,105	CD44	CD24	960	100133941	Gene	Gene	vitamin_D|nmod|START_ENTITY HES1-mediated|dep|vitamin_D HES1-mediated|nsubj|tumor-initiating_subpopulation_in_basal-like_breast_cancer tumor-initiating_subpopulation_in_basal-like_breast_cancer|compound|END_ENTITY	HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin_D analog leads to decreased CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- tumor-initiating_subpopulation_in_basal-like_breast_cancer .
25695620	0	CD44	136,140	CD24	144,148	CD44	CD24	960	100133941	Gene	Gene	Induction|nmod|START_ENTITY Interleukin-8|dep|Induction Cells|amod|Interleukin-8 Cells|compound|END_ENTITY	Human Umbilical Cord Mesenchymal Stem Cells Promote Breast_Cancer_Metastasis by Interleukin-8 - _ and_Interleukin-6-Dependent Induction of CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- Cells .
25945050	0	CD44	0,4	CD24	8,12	CD44	CD24	960	100133941	Gene	Gene	breast_cancer|nsubj|START_ENTITY breast_cancer|nsubj|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- breast_cancer cells exhibit phenotypic reversion in three-dimensional self-assembling peptide RADA16 nanofiber scaffold .
25945050	0	CD44	0,4	CD24	8,12	CD44	CD24	960	100133941	Gene	Gene	breast_cancer|nsubj|START_ENTITY breast_cancer|nsubj|END_ENTITY	CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- breast_cancer cells exhibit phenotypic reversion in three-dimensional self-assembling peptide RADA16 nanofiber scaffold .
26173453	0	CD44	0,4	CD24	6,10	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	CD44 + / CD24 - Cancer Stem Cells Are Associated With Higher Grade of Canine Mammary Carcinomas .
26298632	0	CD44	61,65	CD24	55,59	CD44	CD24	960	100133941	Gene	Gene	expressions|appos|START_ENTITY expressions|compound|END_ENTITY	The clinicopathological and prognostic significance of CD24 , CD44 , CD133 , ALDH1 expressions in invasive_ductal_carcinoma of the breast : CD44/CD24 expression in breast_cancer .
26366219	0	CD44	69,73	CD24	77,81	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY /|nsubj|+ /|dobj|END_ENTITY	Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells -LRB- CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- -RRB- in MCF-7 by Upregulating Mucin1 and EpCAM .
26617852	6	CD44	787,791	CD24	795,799	CD44	CD24	960	100133941	Gene	Gene	-|compound|START_ENTITY CD24|appos|- CD44|dep|CD24 CD44|dep|END_ENTITY	We applied double-staining immunohistochemistry for the detection of CD44 -LRB- + -RRB- / CD24 -LRB- - / low -RRB- , CD44 -LRB- + -RRB- / CD24 -LRB- + -RRB- , CD44 -LRB- - -RRB- / CD24 -LRB- - -RRB- and CD44 -LRB- - -RRB- / CD24 -LRB- + -RRB- cells .
26772398	0	CD44	60,64	CD24	66,70	CD44	CD24	960	100133941	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Decreased expression of autophagy protein LC3 and stemness -LRB- CD44 + / CD24 - / low -RRB- indicate poor prognosis in triple-negative_breast_cancer .
12060392	0	CD44	10,14	CD25	66,70	CD44	CD25	12505(Tax:10090)	16184(Tax:10090)	Gene	Gene	variant|nsubj|START_ENTITY variant|nmod|CD4 CD4|nmod|cells cells|amod|END_ENTITY	Transient CD44 variant isoform expression and reduction in CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- regulatory T cells in C3H/HeJ mice with alopecia areata .
17273993	0	CD44	50,54	CD25	56,60	CD44	CD25	12505(Tax:10090)	16184(Tax:10090)	Gene	Gene	gammadelta|dep|START_ENTITY gammadelta|dep|END_ENTITY	Beta-selection : abundance of TCRbeta - / gammadelta - CD44 - CD25 - -LRB- DN4 -RRB- cells in the foetal thymus .
9174611	0	CD44	75,79	CD25	69,73	CD44	CD25	960	3559	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	Fibroblast dependency during early thymocyte development maps to the CD25 + CD44 + stage and involves interactions with fibroblast matrix molecules .
9176107	0	CD44	142,146	CD25	148,152	CD44	CD25	12505(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
9176107	0	CD44	76,80	CD25	82,86	CD44	CD25	12505(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
9176107	0	CD44	142,146	CD3	137,140	CD44	CD3	12505(Tax:10090)	12503(Tax:10090)	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
12207739	0	CD44	14,18	CD30	51,55	CD44	CD30	960	943	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of CD44 and CD44v6 in primary cutaneous CD30 positive T-cell_lymphoproliferative_disorders .
24425872	0	CD44	0,4	CD31	82,86	CD44	CD31	12505(Tax:10090)	18613(Tax:10090)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	CD44 regulation of endothelial cell proliferation and apoptosis via modulation of CD31 and VE-cadherin expression .
10520039	0	CD44	65,69	CD34	183,187	CD44	CD34	960	947	Gene	Gene	patterns|nmod|START_ENTITY patterns|acl|induced induced|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	Distinct patterns of apoptosis in association with modulation of CD44 induced by thrombopoietin and granulocyte-colony_stimulating_factor during ex vivo expansion of human cord blood CD34 + cells .
10924094	0	CD44	73,77	CD34	25,29	CD44	CD34	960	947	Gene	Gene	expression|compound|START_ENTITY kinetics|nmod|expression kinetics|nmod|cells cells|amod|END_ENTITY	Mobilization kinetics of CD34 -LRB- + -RRB- cells in association with modulation of CD44 and CD31 expression during continuous intravenous administration of G-CSF in normal donors .
15070674	0	CD44	0,4	CD34	74,78	CD44	CD34	960	947	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|SDF-1 SDF-1|nmod|trafficking trafficking|nmod|cells cells|compound|END_ENTITY	CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34 + stem/progenitor cells to bone marrow .
19024325	0	CD44	89,93	CD34	83,87	CD44	CD34	960	947	Gene	Gene	immunophenotype|nummod|START_ENTITY immunophenotype|nummod|END_ENTITY	-LSB- Multiparametric flow cytometry analyzes the expressions of immunophenotype CD133 , CD34 , CD44 in lung_cancer naive cells -RSB- .
19703720	0	CD44	96,100	CD34	34,38	CD44	CD34	960	947	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubjpass|Adhesion Adhesion|nmod|cells cells|appos|+ +|compound|END_ENTITY	Adhesion of human haematopoietic -LRB- CD34 + -RRB- stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4 .
21117906	0	CD44	43,47	CD34	36,40	CD44	CD34	960	947	Gene	Gene	CD90|compound|START_ENTITY CD90|amod|END_ENTITY	Isolation and expansion of synovial CD34 -LRB- - -RRB- CD44 -LRB- + -RRB- CD90 -LRB- + -RRB- mesenchymal stem cells : comparison of an enzymatic method and a direct explant technique .
22155731	0	CD44	23,27	CD34	15,19	CD44	CD34	960	947	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Synovial fluid CD34 CD44 CD90 mesenchymal stem cell levels are associated with the severity of primary_knee_osteoarthritis .
24680978	0	CD44	16,20	CD34	48,52	CD44	CD34	960	947	Gene	Gene	Polymorphism|nmod|START_ENTITY influences|nsubj|Polymorphism influences|dobj|efficacy efficacy|nmod|END_ENTITY	Polymorphism of CD44 influences the efficacy of CD34 -LRB- + -RRB- cells mobilization in patients with hematological_malignancies .
25262448	0	CD44	45,49	CD34	62,66	CD44	CD34	960	947	Gene	Gene	receptor|compound|START_ENTITY silencing|nmod|receptor silencing|nmod|cells cells|compound|END_ENTITY	Polymeric nanoparticle-mediated silencing of CD44 receptor in CD34 + acute_myeloid_leukemia cells .
9326174	0	CD44	14,18	CD34	46,50	CD44	CD34	960	947	Gene	Gene	Antibodies|nmod|START_ENTITY enhance|nsubj|Antibodies enhance|dobj|adhesion adhesion|nmod|cells cells|compound|END_ENTITY	Antibodies to CD44 enhance adhesion of normal CD34 + cells and acute myeloblastic but not lymphoblastic leukaemia cells to bone marrow_stroma .
16497973	0	CD44	7,11	CD4	15,18	CD44	CD4	960	920	Gene	Gene	START_ENTITY|nmod|Th1 Th1|compound|END_ENTITY	Use of CD44 by CD4 + Th1 and Th2 lymphocytes to roll and adhere .
9176107	0	CD44	76,80	CD4	61,64	CD44	CD4	12505(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY thymocytes|nsubj|+ inhibit|parataxis|thymocytes inhibit|dobj|proliferation proliferation|nmod|CD3 CD3|compound|END_ENTITY	Interferons alpha/beta inhibit IL-7-induced proliferation of CD4 - CD8 - CD3 - CD44 + CD25 + thymocytes , but do not inhibit that of CD4 - CD8 - CD3 - CD44 - CD25 - thymocytes .
8721447	0	CD44	0,4	CD44	58,62	CD44	CD44	960	960	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	CD44 and melanocytic_tumors : a possible role for standard CD44 in the epidermotropic spread of melanoma .
8721447	0	CD44	58,62	CD44	0,4	CD44	CD44	960	960	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	CD44 and melanocytic_tumors : a possible role for standard CD44 in the epidermotropic spread of melanoma .
25048464	0	CD44	31,35	CD73	25,29	CD44	CD73	12505(Tax:10090)	23959(Tax:10090)	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	BMP-non-responsive Sca1 + CD73 + CD44 + mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation .
25268239	0	CD44	41,45	CD73	36,40	CD44	CD73	12505(Tax:10090)	23959(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Correction : BMP-Non-Responsive Sca1 + CD73 + CD44 + Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation .
10807126	0	CD44	100,104	CD86	94,98	CD44	CD86	960	942	Gene	Gene	HLA-DR|dep|START_ENTITY HLA-DR|dep|END_ENTITY	Expression of molecules involved in antigen presentation and T cell activation -LRB- HLA-DR , CD80 , CD86 , CD44 and CD54 -RRB- by cultured human osteoblasts .
16962069	0	CD44	24,28	CD90	30,34	CD44	CD90	12505(Tax:10090)	21838(Tax:10090)	Gene	Gene	CNS|compound|START_ENTITY CNS|compound|END_ENTITY	Angiogenic potential of CD44 + CD90 + multipotent CNS stem cells in vitro .
21836053	0	CD44	47,51	CD90	53,57	CD44	CD90	960	7070	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Reconstruction of human elastic cartilage by a CD44 + CD90 + stem cell in the ear perichondrium .
22155731	0	CD44	23,27	CD90	31,35	CD44	CD90	960	7070	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Synovial fluid CD34 CD44 CD90 mesenchymal stem cell levels are associated with the severity of primary_knee_osteoarthritis .
25342622	0	CD44	45,49	COX-2	24,29	CD44	COX-2	960	4513	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Hyaluronic acid induces COX-2 expression via CD44 in orbital fibroblasts from patients with thyroid-associated_ophthalmopathy .
21457936	0	CD44	30,34	E-Selectin	51,61	CD44	E-Selectin	960	6401	Gene	Gene	contribution|nmod|START_ENTITY contribution|nmod|ligand ligand|nmod|END_ENTITY	Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment .
15994957	0	CD44	0,4	E-selectin	47,57	CD44	E-selectin	960	6401	Gene	Gene	possesses|nsubj|START_ENTITY possesses|dobj|activity activity|amod|END_ENTITY	CD44 on LS174T colon_carcinoma cells possesses E-selectin ligand activity .
25339657	0	CD44	0,4	E-selectin	70,80	CD44	E-selectin	960	6401	Gene	Gene	isoforms|nummod|START_ENTITY functional|nsubj|isoforms functional|dobj|ligands ligands|amod|END_ENTITY	CD44 variant isoforms expressed by breast_cancer cells are functional E-selectin ligands under flow conditions .
25359776	0	CD44	27,31	E-selectin	76,86	CD44	E-selectin	960	6401	Gene	Gene	Organization|compound|START_ENTITY Regulation|nmod|Organization Regulation|nmod|END_ENTITY	Cytoskeletal Regulation of CD44 Membrane Organization and Interactions with E-selectin .
26124272	0	CD44	68,72	E-selectin	33,43	CD44	E-selectin	960	6401	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|compound|END_ENTITY	Quantitative Characterization of E-selectin Interaction with Native CD44 and P-selectin_Glycoprotein_Ligand-1 -LRB- PSGL-1 -RRB- Using a Real Time Immunoprecipitation-based Binding Assay .
11893033	0	CD44	0,4	EGFR	21,25	CD44	EGFR	960	1956	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	CD44 associates with EGFR and erbB2 in metastasizing mammary_carcinoma cells .
18276068	0	CD44	111,115	EGFR	0,4	CD44	EGFR	960	1956	Gene	Gene	effect|nmod|START_ENTITY CD44|dobj|effect coupled|xcomp|CD44 coupled|nsubjpass|END_ENTITY	EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding , internalization and motogenic effect of CD44 .
18276068	0	CD44	43,47	EGFR	0,4	CD44	EGFR	960	1956	Gene	Gene	coupled|xcomp|START_ENTITY coupled|nsubjpass|END_ENTITY	EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding , internalization and motogenic effect of CD44 .
22110198	0	CD44	41,45	EGFR	21,25	CD44	EGFR	960	1956	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast_cancer cells .
22110198	0	CD44	41,45	EGFR	79,83	CD44	EGFR	960	1956	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast_cancer cells .
23265944	0	CD44	0,4	EGFR	20,24	CD44	EGFR	960	1956	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD44 interacts with EGFR and promotes head_and_neck_squamous_cell_carcinoma initiation and progression .
26757432	0	CD44	30,34	EGFR	42,46	CD44	EGFR	960	1956	Gene	Gene	relationship|nmod|START_ENTITY /|nsubj|relationship /|dobj|phenotype phenotype|amod|END_ENTITY	The relationship between EMT , CD44 -LRB- high -RRB- / EGFR -LRB- low -RRB- phenotype , and treatment response in head_and_neck_cancer cell lines .
22086849	0	CD44	21,25	ERK1/2	0,6	CD44	ERK1/2	12505(Tax:10090)	26417;26413	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	ERK1/2 regulation of CD44 modulates oral cancer_aggressiveness .
22673910	0	CD44	24,28	ESRP1	37,42	CD44	ESRP1	12505(Tax:10090)	207920(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell .
8674281	0	CD44	102,106	Epidermal_growth_factor	0,23	CD44	Epidermal growth factor	12505(Tax:10090)	13645(Tax:10090)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Epidermal_growth_factor modulates cell attachment to hyaluronic acid by the cell surface glycoprotein CD44 .
9162042	0	CD44	32,36	Epidermal_growth_factor	0,23	CD44	Epidermal growth factor	12505(Tax:10090)	13645(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts .
20456444	0	CD44	27,31	Erythropoietin	0,14	CD44	Erythropoietin	960	2056	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Erythropoietin and soluble CD44 levels in patients with primary_open-angle_glaucoma .
15728736	0	CD44	196,200	GlcNAc6ST-1	98,109	CD44	GlcNAc6ST-1	960	9435	Gene	Gene	implicated|nmod|START_ENTITY implicated|nsubjpass|END_ENTITY	Expression of N-acetylglucosamine 6-O-sulfotransferases -LRB- GlcNAc6STs -RRB- -1 _ and _ -4 in human monocytes : GlcNAc6ST-1 is implicated in the generation of the 6-sulfo_N-acetyllactosamine / Lewis x epitope on CD44 and is induced by TNF-alpha .
21044318	0	CD44	11,15	HER2	102,106	CD44	HER2	960	2064	Gene	Gene	+|nsubj|START_ENTITY +|nmod|functions functions|nmod|END_ENTITY	Increasing CD44 + / CD24 -LRB- - -RRB- tumor stem cells , and upregulation of COX-2 and HDAC6 , as major functions of HER2 in breast tumorigenesis .
21925125	0	CD44	20,24	HER2	0,4	CD44	HER2	960	2064	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric_cancer cells .
22565037	0	CD44	67,71	HER2	151,155	CD44	HER2	960	2064	Gene	Gene	CD24|compound|START_ENTITY initiating|dobj|CD24 initiating|parataxis|sufficient sufficient|xcomp|overcome overcome|nmod|xenografts xenografts|amod|trastuzumab trastuzumab|nmod|+ +|compound|END_ENTITY	Metformin-induced preferential killing of breast_cancer initiating CD44 + CD24 - / low cells is sufficient to overcome primary resistance to trastuzumab in HER2 + human breast_cancer xenografts .
22937154	0	CD44	18,22	HIF-1a	56,62	CD44	HIF-1a	960	3091	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Hypoxia regulates CD44 and its variant isoforms through HIF-1a in triple negative breast_cancer .
12193230	0	CD44	101,105	IFN-gamma	44,53	CD44	IFN-gamma	12505(Tax:10090)	15978(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY cytokines|appos|VCAM-1 cytokines|appos|IL-2 IL-2|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
10202038	0	CD44	20,24	IL-1	38,42	CD44	IL-1	960	3552	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	Characterization of CD44 induction by IL-1 : a critical role for Egr-1 .
12193230	0	CD44	101,105	IL-10	55,60	CD44	IL-10	12505(Tax:10090)	16153(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY cytokines|appos|VCAM-1 cytokines|appos|IL-2 IL-2|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
15728517	0	CD44	105,109	IL-1_receptor_associated_kinase-M	56,89	CD44	IL-1 receptor associated kinase-M	960	11213	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Tumor cells deactivate human monocytes by up-regulating IL-1_receptor_associated_kinase-M expression via CD44 and TLR4 .
10415067	0	CD44	32,36	IL-2	107,111	CD44	IL-2	12505(Tax:10090)	16183(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY Evidence|nmod|involvement Evidence|nmod|vascular_leak_syndrome vascular_leak_syndrome|nmod|END_ENTITY	Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular_leak_syndrome by IL-2 .
11123292	0	CD44	64,68	IL-2	87,91	CD44	IL-2	960	3558	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma .
12193230	0	CD44	101,105	IL-2	38,42	CD44	IL-2	12505(Tax:10090)	16183(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY cytokines|appos|VCAM-1 cytokines|appos|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
19635906	0	CD44	0,4	IL-2	96,100	CD44	IL-2	12505(Tax:10090)	16183(Tax:10090)	Gene	Gene	costimulation|compound|START_ENTITY promotes|nsubj|costimulation promotes|dobj|persistence persistence|nmod|production production|nmod|END_ENTITY	CD44 costimulation promotes FoxP3 + regulatory T cell persistence and function via production of IL-2 , IL-10 , and TGF-beta .
8580076	0	CD44	74,78	IL-2	105,109	CD44	IL-2	12505(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	CD44 plays a co-stimulatory role in murine T cell activation : ligation of CD44 selectively co-stimulates IL-2 production , but not proliferation in TCR-stimulated murine Th1 cells .
15014527	0	CD44	15,19	IL-6	0,4	CD44	IL-6	960	3569	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-6 regulates CD44 cell surface expression on human myeloma cells .
18451609	0	CD44	0,4	IL-6	27,31	CD44	IL-6	12505(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|nsubj|START_ENTITY expression|nmod|mice mice|compound|END_ENTITY	CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation .
25126764	0	CD44	41,45	IL-6	69,73	CD44	IL-6	960	3569	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	Low molecular weight hyaluronan mediated CD44 dependent induction of IL-6 and chemokines in human dermal fibroblasts potentiates innate immune response .
11095749	0	CD44	24,28	L-selectin	35,45	CD44	L-selectin	960	6402	Gene	Gene	glycoform|nmod|START_ENTITY ligand|nsubj|glycoform ligand|amod|END_ENTITY	A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells .
8757865	0	CD44	141,145	L-selectin	129,139	CD44	L-selectin	12505(Tax:10090)	20343(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased susceptibility to primary_infection with Listeria_monocytogenes in germfree mice may be due to lack of accumulation of L-selectin + CD44 + T cells in sites of inflammation .
26772398	0	CD44	60,64	LC3	42,45	CD44	LC3	960	84557	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	Decreased expression of autophagy protein LC3 and stemness -LRB- CD44 + / CD24 - / low -RRB- indicate poor prognosis in triple-negative_breast_cancer .
12193230	0	CD44	101,105	LFA-1	94,99	CD44	LFA-1	12505(Tax:10090)	16414(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
7537255	0	CD44	13,17	LMP1	79,83	CD44	LMP1	960	17494204	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Induction of CD44 expression by the Epstein-Barr_virus latent membrane protein LMP1 is associated with lymphoma_dissemination .
20127679	0	CD44	55,59	LSECtin	26,33	CD44	LSECtin	960	339390	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	The DC-SIGN family member LSECtin is a novel ligand of CD44 on activated T cells .
19170073	0	CD44	45,49	LYVE-1	38,44	CD44	LYVE-1	12505(Tax:10090)	114332(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Lack of lymphatic vessel phenotype in LYVE-1 / CD44 double knockout mice .
20417561	0	CD44	0,4	Lck	29,32	CD44	Lck	960	3932	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD44 interacts directly with Lck in a zinc-dependent manner .
9573028	0	CD44	0,4	Lck	76,79	CD44	Lck	960	3932	Gene	Gene	associates|nummod|START_ENTITY kinases|nsubj|associates kinases|dobj|END_ENTITY	CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes .
25566991	0	CD44	0,4	MT1-MMP	50,57	CD44	MT1-MMP	960	4323	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CD44 regulates pancreatic_cancer_invasion through MT1-MMP .
11381077	0	CD44	49,53	Membrane-type_1_matrix_metalloproteinase	0,40	CD44	Membrane-type 1 matrix metalloproteinase	960	4323	Gene	Gene	START_ENTITY|nsubj|cleaves cleaves|amod|END_ENTITY	Membrane-type_1_matrix_metalloproteinase cleaves CD44 and promotes cell migration .
26198939	0	CD44	48,52	MicroRNA-34a	1,13	CD44	MicroRNA-34a	960	407040	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	-LSB- MicroRNA-34a regulates cell cycle by targeting CD44 in human bladder_carcinoma cells -RSB- .
26198939	0	CD44	48,52	MicroRNA-34a	1,13	CD44	MicroRNA-34a	960	407040	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	-LSB- MicroRNA-34a regulates cell cycle by targeting CD44 in human bladder_carcinoma cells -RSB- .
26091086	0	CD44	33,37	Nestin	25,31	CD44	Nestin	25406(Tax:10116)	25491(Tax:10116)	Gene	Gene	Vascular_Endothelial_Growth_Factor|appos|START_ENTITY Vascular_Endothelial_Growth_Factor|compound|END_ENTITY	Changes in Expression of Nestin , CD44 , Vascular_Endothelial_Growth_Factor , and Glutamine Synthetase by Mature M ller Cells After Dedifferentiation .
21215700	0	CD44	60,64	OPN	0,3	CD44	OPN	960	6696	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	OPN promotes survival of activated T cells by up-regulating CD44 in patients with oral_lichen_planus .
25009318	0	CD44	58,62	OPN	36,39	CD44	OPN	960	6696	Gene	Gene	START_ENTITY|nsubj|association association|nmod|osteopontin osteopontin|appos|END_ENTITY	Genetic association of osteopontin -LRB- OPN -RRB- and its receptor CD44 genes with susceptibility to Chinese gastric_cancer patients .
12529435	0	CD44	70,74	Osteopontin	0,11	CD44	Osteopontin	12505(Tax:10090)	20750(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY due|nmod|expression produces|xcomp|due produces|nsubj|deficiency deficiency|compound|END_ENTITY	Osteopontin deficiency produces osteoclast_dysfunction due to reduced CD44 surface expression .
15325806	0	CD44	22,26	Osteopontin	0,11	CD44	Osteopontin	12505(Tax:10090)	20750(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells .
18997126	0	CD44	26,30	Osteopontin	0,11	CD44	Osteopontin	960	6696	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|END_ENTITY	Osteopontin combined with CD44 , a novel prognostic biomarker for patients with hepatocellular_carcinoma undergoing curative resection .
22807608	0	CD44	64,68	Osteopontin	0,11	CD44	Osteopontin	12505(Tax:10090)	20750(Tax:10090)	Gene	Gene	manner|compound|START_ENTITY growth|nmod|manner growth|compound|END_ENTITY	Osteopontin increases_hepatocellular_carcinoma cell growth in a CD44 dependant manner .
24531809	0	CD44	82,86	Osteopontin	0,11	CD44	Osteopontin	12505(Tax:10090)	20750(Tax:10090)	Gene	Gene	receptors|nummod|START_ENTITY involvement|nmod|receptors myocytes|nmod|involvement apoptosis|nmod|myocytes apoptosis|nsubj|stimulates stimulates|compound|END_ENTITY	Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors , mitochondrial death pathway , and endoplasmic_reticulum_stress .
1912477	0	CD44	16,20	P80	22,25	CD44	P80	960	8161	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of CD44 -LRB- P80 -RRB- on the external surface of a human astrocytoma cell .
22977525	0	CD44	87,91	PTPRD	21,26	CD44	PTPRD	960	5789	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Tyrosine phosphatase PTPRD suppresses colon_cancer cell migration in coordination with CD44 .
20559002	0	CD44	42,46	Pen	0,3	CD44	Pen	960	340348	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Pen ch_13 major fungal allergen decreases CD44 expression in human bronchial epithelial cells .
1689752	0	CD44	92,96	Pgp-1	97,102	CD44	Pgp-1	960	960	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Homotypic cell aggregation induced by anti-CD44 -LRB- Pgp-1 -RRB- monoclonal antibodies and related to CD44 -LRB- Pgp-1 -RRB- expression .
1902176	0	CD44	124,128	Pgp-1	117,122	CD44	Pgp-1	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Elevated production of interferon-gamma and interleukin_4 by mature T cells from autoimmune lpr mice correlates with Pgp-1 -LRB- CD44 -RRB- expression .
20962267	0	CD44	27,31	Podoplanin	0,10	CD44	Podoplanin	960	10630	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Podoplanin associates with CD44 to promote directional cell migration .
12714503	0	CD44	36,40	RANTES	0,6	CD44	RANTES	960	6352	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	RANTES -LRB- CCL5 -RRB- uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1_enhancement .
25101858	0	CD44	0,4	RhoA	18,22	CD44	RhoA	960	387	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	CD44 acts through RhoA to regulate YAP signaling .
15070674	0	CD44	0,4	SDF-1	40,45	CD44	SDF-1	960	6387	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34 + stem/progenitor cells to bone marrow .
25048464	0	CD44	31,35	Sca1	19,23	CD44	Sca1	12505(Tax:10090)	110454(Tax:10090)	Gene	Gene	marrow|compound|START_ENTITY derived|nsubj|marrow +|ccomp|derived +|nsubj|END_ENTITY	BMP-non-responsive Sca1 + CD73 + CD44 + mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation .
25268239	0	CD44	41,45	Sca1	31,35	CD44	Sca1	12505(Tax:10090)	110454(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Correction : BMP-Non-Responsive Sca1 + CD73 + CD44 + Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation .
19010442	0	CD44	27,31	TIMP-1	0,6	CD44	TIMP-1	960	7076	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	TIMP-1 binding to proMMP-9 / CD44 complex localized at the cell surface promotes erythroid cell survival .
18502033	0	CD44	14,18	TIMP1	0,5	CD44	TIMP1	960	7076	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation .
15060082	0	CD44	68,72	TSG-6	0,5	CD44	TSG-6	960	7130	Gene	Gene	interaction|nmod|START_ENTITY modulates|dobj|interaction modulates|nsubj|END_ENTITY	TSG-6 modulates the interaction between hyaluronan and cell surface CD44 .
12867430	0	CD44	76,80	Tumor_necrosis_factor-alpha	0,27	CD44	Tumor necrosis factor-alpha	960	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38_mitogen-activated_protein_kinase in lipopolysaccharide-stimulated human monocytic cells .
16908592	0	CD44	53,57	Tumor_necrosis_factor-alpha	0,27	CD44	Tumor necrosis factor-alpha	960	7124	Gene	Gene	expression|nummod|START_ENTITY modulates|dobj|expression modulates|nsubj|differentially differentially|amod|END_ENTITY	Tumor_necrosis_factor-alpha differentially modulates CD44 expression in ovarian_cancer cells .
24212937	0	CD44	166,170	Vimentin	15,23	CD44	Vimentin	960	7431	Gene	Gene	Surface|dep|START_ENTITY Expressed|nmod|Surface Expressed|nsubjpass|Domains Domains|nmod|END_ENTITY	Two Domains of Vimentin Are Expressed on the Surface of Lymph Node , Bone and Brain Metastatic Prostate Cancer Lines along with the Putative Stem Cell Marker Proteins CD44 and CD133 .
20332234	0	CD44	50,54	Y-box_binding_protein-1	0,23	CD44	Y-box binding protein-1	960	4904	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Y-box_binding_protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal , mammosphere growth , and drug resistance .
20802512	0	CD44	132,136	Y-box_binding_protein-1	28,51	CD44	Y-box binding protein-1	960	4904	Gene	Gene	cells|nummod|START_ENTITY increasing|dobj|cells serine|advcl|increasing serine|nsubj|expression expression|nmod|END_ENTITY	The expression of activated Y-box_binding_protein-1 serine 102 mediates trastuzumab resistance in breast_cancer cells by increasing CD44 + cells .
23346166	0	CD44	44,48	bFGF	10,14	CD44	bFGF	960	2247	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bFGF on the MCF-7 Cell Cycle with CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- : Promoting the G0/G1 > G2/S Transition .
12421945	0	CD44	174,178	c-Jun_N-terminal_kinase	135,158	CD44	c-Jun N-terminal kinase	960	5599	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Differential regulation of CD44 expression by lipopolysaccharide -LRB- LPS -RRB- and TNF-alpha in human monocytic cells : distinct involvement of c-Jun_N-terminal_kinase in LPS-induced CD44 expression .
10037743	0	CD44	25,29	c-Met	144,149	CD44	c-Met	960	4233	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met .
11073815	0	CD44	62,66	c-Met	14,19	CD44	c-Met	960	4233	Gene	Gene	forms|nmod|START_ENTITY forms|amod|END_ENTITY	Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal_cancer .
12183053	0	CD44	0,4	c-Met	100,105	CD44	c-Met	960	4233	Gene	Gene	stimulation|nummod|START_ENTITY induces|nsubj|stimulation induces|dobj|phosphorylation phosphorylation|nmod|protein protein|amod|END_ENTITY	CD44 stimulation by fragmented hyaluronic_acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells .
17923692	0	CD44	74,78	c-Met	22,27	CD44	c-Met	12505(Tax:10090)	17295(Tax:10090)	Gene	Gene	collaboration|nmod|START_ENTITY identifies|dobj|collaboration identifies|nsubj|Haploinsufficiency Haploinsufficiency|nmod|END_ENTITY	Haploinsufficiency of c-Met in cd44 - / - mice identifies a collaboration of CD44 and c-Met in vivo .
21680714	0	CD44	68,72	c-Met	0,5	CD44	c-Met	12505(Tax:10090)	17295(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY compensate|nmod|loss coreceptor|acl|compensate recruits|nmod|coreceptor recruits|nsubj|END_ENTITY	c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice .
24823486	0	CD44	40,44	c-Met	14,19	CD44	c-Met	960	4233	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal_cancer liver metastasis model .
11084024	0	CD44	0,4	c-Src_kinase	22,34	CD44	c-Src kinase	960	1445	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	CD44 interaction with c-Src_kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian_tumor cell migration .
20199686	0	CD44	40,44	egfr	20,24	CD44	egfr	960	1956	Gene	Gene	+|compound|START_ENTITY regain|nmod|+ regain|nmod|copies copies|compound|END_ENTITY	Selective regain of egfr gene copies in CD44 + / CD24 - / low breast_cancer cellular model MDA-MB-468 .
12032545	0	CD44	41,45	ezrin	46,51	CD44	ezrin	960	7430	Gene	Gene	association|compound|START_ENTITY association|compound|END_ENTITY	A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility .
12297287	0	CD44	0,4	focal_adhesion_kinase	23,44	CD44	focal adhesion kinase	12505(Tax:10090)	14083(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	CD44 signaling through focal_adhesion_kinase and its anti-apoptotic effect .
10803777	0	CD44	51,55	hyaluronate_receptor	29,49	CD44	hyaluronate receptor	960	960	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of hyaluronate_receptor -LRB- CD44 -RRB- in alcoholic liver_disease .
21895545	0	CD44	26,30	intercellular_adhesion_molecule-1	32,65	CD44	intercellular adhesion molecule-1	960	3383	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Prognostic value of serum CD44 , intercellular_adhesion_molecule-1 and vascular_cell_adhesion_molecule-1 levels in patients with indolent non-Hodgkin_lymphomas .
10383394	0	CD44	0,4	interferon-gamma	75,91	CD44	interferon-gamma	960	3458	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|binding binding|nmod|END_ENTITY	CD44 , a cell surface chondroitin sulfate proteoglycan , mediates binding of interferon-gamma and some of its biological effects on human vascular smooth muscle cells .
12077104	0	CD44	141,145	interleukin_6	164,177	CD44	interleukin 6	960	3569	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	High frequency of autoantibodies in patients with primary_sclerosing_cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin_6 .
21055388	0	CD44	20,24	miR-199a-3p	0,11	CD44	miR-199a-3p	960	406977	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular_carcinoma cell lines .
21240262	0	CD44	95,99	miR-34a	13,20	CD44	miR-34a	12505(Tax:10090)	723848(Tax:10090)	Gene	Gene	repressing|dobj|START_ENTITY stem|advcl|repressing stem|nsubj|prostate_cancer prostate_cancer|amod|END_ENTITY	The microRNA miR-34a inhibits prostate_cancer stem cells and metastasis by directly repressing CD44 .
23314380	0	CD44	86,90	miR-34a	0,7	CD44	miR-34a	960	407040	Gene	Gene	expression|nmod|START_ENTITY repressing|dobj|expression inhibits|advcl|repressing inhibits|nsubj|END_ENTITY	miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44 .
24019906	0	CD44	4,8	miR-34a	84,91	CD44	miR-34a	12505(Tax:10090)	723848(Tax:10090)	Gene	Gene	subsets|compound|START_ENTITY enriched|nsubjpass|subsets enriched|nmod|expression expression|amod|END_ENTITY	The CD44 -LRB- high -RRB- tumorigenic subsets in lung_cancer biospecimens are enriched for low miR-34a expression .
24116237	0	CD44	16,20	miR-34a	96,103	CD44	miR-34a	960	407040	Gene	Gene	START_ENTITY|acl:relcl|Enriched Enriched|nmod|Expression Expression|amod|END_ENTITY	Correction : The CD44 -LRB- high -RRB- Tumorigenic Subsets in Lung Cancer Biospecimens Are Enriched for Low miR-34a Expression .
26035691	0	CD44	115,119	miR-34a	107,114	CD44	miR-34a	960	407040	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Depletion of histone_deacetylase_1 inhibits metastatic abilities of gastric_cancer cells by regulating the miR-34a / CD44 pathway .
26231042	0	CD44	114,118	miR-34a	32,39	CD44	miR-34a	960	407040	Gene	Gene	repressing|dobj|START_ENTITY stem|advcl|repressing stem|nsubj|prostate_cancer prostate_cancer|amod|END_ENTITY	Registered report : the microRNA miR-34a inhibits prostate_cancer stem cells and metastasis by directly repressing CD44 .
24866595	0	CD44	68,72	miRNA-34a	0,9	CD44	miRNA-34a	960	407040	Gene	Gene	Suppresses|nmod|START_ENTITY Suppresses|nsubj|END_ENTITY	miRNA-34a Suppresses Cell Proliferation and Metastasis by Targeting CD44 in Human Renal_Carcinoma Cells .
23695867	0	CD44	62,66	mucin	27,32	CD44	mucin	281057(Tax:9913)	404104(Tax:9913)	Gene	Gene	associated|nmod|START_ENTITY accumulation|acl|associated accumulation|compound|END_ENTITY	Cytoplasmic non-epithelial mucin accumulation associated with CD44 in an astrocytic_tumor with signet ring features .
10088720	0	CD44	0,4	osteopontin	37,48	CD44	osteopontin	960	6696	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	CD44 is not an adhesive receptor for osteopontin .
10733576	0	CD44	54,58	osteopontin	12,23	CD44	osteopontin	12505(Tax:10090)	20750(Tax:10090)	Gene	Gene	surface|dobj|START_ENTITY surface|nsubj|Coupling Coupling|nmod|END_ENTITY	Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage_colony-stimulating_factor .
16402410	0	CD44	18,22	osteopontin	4,15	CD44	osteopontin	12505(Tax:10090)	20750(Tax:10090)	Gene	Gene	superfluous|nsubj|START_ENTITY END_ENTITY|parataxis|superfluous	The osteopontin - CD44 pathway is superfluous for the development of autoimmune_myocarditis .
16631740	0	CD44	73,77	osteopontin	137,148	CD44	osteopontin	960	6696	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression required|nmod|regulation required|nmod|END_ENTITY	Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression , MMP-2 secretion , and cell migration by osteopontin in human melanoma cells .
16691370	0	CD44	22,26	osteopontin	58,69	CD44	osteopontin	960	6696	Gene	Gene	variant|compound|START_ENTITY variant|acl:relcl|facilitates facilitates|nsubj|expression expression|nmod|END_ENTITY	Enhanced cell surface CD44 variant -LRB- v6 , v9 -RRB- expression by osteopontin in breast_cancer epithelial cells facilitates tumor cell migration : novel post-transcriptional , post-translational regulation .
25009318	0	CD44	58,62	osteopontin	23,34	CD44	osteopontin	960	6696	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Genetic association of osteopontin -LRB- OPN -RRB- and its receptor CD44 genes with susceptibility to Chinese gastric_cancer patients .
9892210	0	CD44	0,4	osteopontin	97,108	CD44	osteopontin	960	6696	Gene	Gene	variants|compound|START_ENTITY cooperate|nsubj|variants cooperate|xcomp|permit permit|advcl|END_ENTITY	CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic_acid , thereby stimulating cell motility and chemotaxis .
19047049	0	CD44	20,24	p300	42,46	CD44	p300	960	2033	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast_tumor cells .
10383941	0	CD44	0,4	p56lck	23,29	CD44	p56lck	960	3932	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
22386367	0	CD44	14,18	tumor_necrosis_factor-a	33,56	CD44	tumor necrosis factor-a	960	7124	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of CD44 expression by tumor_necrosis_factor-a and its potential role in breast_cancer cell migration .
15923644	0	CD44	207,211	tumor_necrosis_factor-alpha	148,175	CD44	tumor necrosis factor-alpha	960	7124	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Differential involvement of calmodulin-dependent protein kinase II-activated AP-1 and c-Jun_N-terminal_kinase-activated EGR-1 signaling pathways in tumor_necrosis_factor-alpha and lipopolysaccharide-induced CD44 expression in human monocytic cells .
7542295	0	CD44	17,21	tumor_necrosis_factor-alpha	36,63	CD44	tumor necrosis factor-alpha	960	7124	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of CD44 expression by tumor_necrosis_factor-alpha is neutralized by interleukin-10 in Langerhans cells .
22216242	0	CD44	8,12	vimentin	58,66	CD44	vimentin	960	7431	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Soluble CD44 interacts with intermediate filament protein vimentin on endothelial cell surface .
8955171	0	CD45	25,29	CD100	0,5	CD45	CD100	5788	10507	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	CD100 is associated with CD45 at the surface of human T lymphocytes .
14602575	0	CD45	88,92	CD11b	98,103	CD45	CD11b	19264(Tax:10090)	16409(Tax:10090)	Gene	Gene	monocytes|amod|START_ENTITY monocytes|amod|END_ENTITY	CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45 -LRB- high -RRB- CD11b -LRB- + -RRB- monocytes and enhanced Theiler 's murine encephalomyelitis virus-induced demyelinating_disease .
21715308	0	CD45	37,41	CD133	44,49	CD45	CD133	5788	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adult human circulating CD34 Lin CD45 CD133 cells can differentiate into hematopoietic and endothelial cells .
25739938	0	CD45	12,16	CD19	18,22	CD45	CD19	5788	930	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	A subset of CD45 + / CD19 - cells in bone marrow may be associated with clinical outcomes of patients with mantle_cell_lymphoma .
1980615	0	CD45	29,33	CD2	15,18	CD45	CD2	19264(Tax:10090)	12481(Tax:10090)	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of CD2 and T200 -LRB- CD45 -RRB- in mouse T lymphocytes .
26561584	0	CD45	30,34	CD22	61,65	CD45	CD22	5788	933	Gene	Gene	function|nmod|START_ENTITY mediated|nsubjpass|function mediated|nmod|END_ENTITY	An extracatalytic function of CD45 in B cells is mediated by CD22 .
1693592	0	CD45	41,45	CD30	58,62	CD45	CD30	5788	943	Gene	Gene	antigen|appos|START_ENTITY antigen|nmod|END_ENTITY	Variable expression of leucocyte-common -LRB- CD45 -RRB- antigen in CD30 -LRB- Ki1 -RRB- - positive anaplastic_large-cell_lymphoma : implications for the differential diagnosis between lymphoid and nonlymphoid malignancies .
23922300	0	CD45	20,24	CD31	26,30	CD45	CD31	5788	5175	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|+ +|dep|+ +|compound|END_ENTITY	Characterization of CD45 - / CD31 + / CD105 + circulating cells in the peripheral blood of patients with gynecologic malignancies .
23922300	6	CD45	1528,1532	CD31	1536,1540	CD45	CD31	5788	5175	Gene	Gene	expressed|nsubj|START_ENTITY expressed|advmod|uniformly uniformly|nmod:npmod|END_ENTITY	Furthermore , CD45 -LRB- - -RRB- / CD31 -LRB- + -RRB- / CD105 -LRB- + -RRB- cells uniformly expressed the monocyte-specific markers CD14 and CD68 .
23974360	0	CD45	20,24	CD31	26,30	CD45	CD31	19264(Tax:10090)	18613(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ cells|amod|+ cells|compound|END_ENTITY	Injection of Sca-1 + / CD45 + / CD31 + mouse bone mesenchymal stromal-like cells improves cardiac function in a mouse myocardial_infarct model .
24590887	0	CD45	6,10	CD31	12,16	CD45	CD31	5788	5175	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	About CD45 - / CD31 + / CD105 + circulating cells in patients with gynecologic malignancies -- response .
25232467	7	CD45	1104,1108	CD31	1122,1126	CD45	CD31	5788	5175	Gene	Gene	START_ENTITY|dobj|CD146 CD146|amod|END_ENTITY	In five out of seven donors , telomeres in candidate native UC MSCs -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- + -RRB- -RRB- were longer compared to donor-matched CD146 -LRB- - -RRB- population -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- - -RRB- -RRB- .
25243061	7	CD45	1104,1108	CD31	1122,1126	CD45	CD31	5788	5175	Gene	Gene	START_ENTITY|dobj|CD146 CD146|amod|END_ENTITY	In three out of four donors , telomeres in candidate native UC MSCs -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- + -RRB- -RRB- were longer compared to donor-matched CD146 -LRB- - -RRB- population -LRB- CD45 -LRB- - -RRB- CD235a -LRB- - -RRB- CD31 -LRB- - -RRB- CD146 -LRB- - -RRB- -RRB- .
12393728	0	CD45	0,4	CD34	85,89	CD45	CD34	19264(Tax:10090)	12490(Tax:10090)	Gene	Gene	phosphatase|nummod|START_ENTITY inhibits|nsubj|phosphatase inhibits|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34 + cells associated with selective inactivation of Lyn .
1694223	0	CD45	24,28	CD34	70,74	CD45	CD34	5788	947	Gene	Gene	isoforms|nummod|START_ENTITY isoforms|nmod|subpopulations subpopulations|nmod|END_ENTITY	Selective expression of CD45 isoforms on functional subpopulations of CD34 + hemopoietic cells from human bone marrow .
20493838	0	CD45	41,45	CD34	33,37	CD45	CD34	5788	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Impaired function of circulating CD34 -LRB- + -RRB- CD45 -LRB- - -RRB- cells in patients with proliferative_diabetic_retinopathy .
20568956	0	CD45	21,25	CD34	28,32	CD45	CD34	5788	947	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Umbilical cord blood CD45 -LRB- + -RRB- CD34 -LRB- + -RRB- cells coexpression in preterm and full-term neonates : a pilot study .
21715308	0	CD45	37,41	CD34	24,28	CD45	CD34	5788	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adult human circulating CD34 Lin CD45 CD133 cells can differentiate into hematopoietic and endothelial cells .
21789899	0	CD45	34,38	CD34	40,44	CD45	CD34	24699(Tax:10116)	305081(Tax:10116)	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Protection of bone marrow-derived CD45 + / CD34 - / lin - stromal cells with immunosuppressant activity against ischemia/reperfusion injury in rats .
23383116	0	CD45	12,16	CD34	19,23	CD45	CD34	24699(Tax:10116)	305081(Tax:10116)	Gene	Gene	KDR|compound|START_ENTITY KDR|dep|+ +|compound|END_ENTITY	Analysis of CD45 - -LSB- CD34 + / KDR + -RSB- endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic_stroke .
24763009	0	CD45	31,35	CD34	12,16	CD45	CD34	5788	947	Gene	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	-LSB- Changes of CD34 -LRB- + -RRB- and CD71 -LRB- + -RRB- CD45 -LRB- - -RRB- cell levels in bone marrow of MDS and AA patients -RSB- .
25332796	0	CD45	87,91	CD34	80,84	CD45	CD34	5788	947	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Percutaneous coronary intervention causes a rapid but transient mobilisation of CD34 -LRB- + -RRB- CD45 -LRB- - -RRB- cells .
26655331	0	CD45	108,112	CD34	100,104	CD45	CD34	5788	947	Gene	Gene	muscle|compound|START_ENTITY muscle|dep|Aging Aging|nmod|gain gain|nmod|properties properties|nmod|population population|nmod|END_ENTITY	Aging induced loss_of_stemness with concomitant gain of myogenic properties of a pure population of CD34 -LRB- + -RRB- / CD45 -LRB- - -RRB- muscle derived stem cells .
10050677	0	CD45	0,4	CD4	75,78	CD45	CD4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	act|nsubj|START_ENTITY act|nmod|thymocytes thymocytes|amod|early early|nmod|+ +|compound|END_ENTITY	CD45 can act as a negative regulator for the transition from early to late CD4 + CD8 + thymocytes .
10602008	0	CD45	0,4	CD4	42,45	CD45	CD4	5788	920	Gene	Gene	phenotypes|nummod|START_ENTITY phenotypes|dep|END_ENTITY	CD45 isoform phenotypes of human T cells : CD4 -LRB- + -RRB- CD45RA -LRB- - -RRB- RO -LRB- + -RRB- memory T cells re-acquire CD45RA without losing CD45RO .
10809380	0	CD45	25,29	CD4	52,55	CD45	CD4	5788	920	Gene	Gene	isoforms|nummod|START_ENTITY distribution|nmod|isoforms expressed|nsubj|distribution expressed|nmod|+ +|compound|END_ENTITY	Abnormal distribution of CD45 isoforms expressed by CD4 + and CD8 + T cells in rheumatoid_arthritis .
11166373	0	CD45	50,54	CD4	83,86	CD45	CD4	5788	920	Gene	Gene	antigen|nummod|START_ENTITY antigen|nmod|T T|compound|END_ENTITY	Deficiency of the expression of CD45RA isoform of CD45 common leukocyte antigen in CD4 + T lymphocytes in children with infantile cholestasis .
11694532	0	CD45	28,32	CD4	47,50	CD45	CD4	5788	920	Gene	Gene	isoforms|nummod|START_ENTITY isoforms|nmod|END_ENTITY	Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T_cell_antigen_receptor signal transduction .
12204964	0	CD45	53,57	CD4	11,14	CD45	CD4	5788	920	Gene	Gene	gating|nummod|START_ENTITY T-cell|dep|gating END_ENTITY|dep|T-cell	Affordable CD4 -LRB- + -RRB- - T-cell counting by flow cytometry : CD45 gating for volumetric analysis .
12583540	0	CD45	83,87	CD4	51,54	CD45	CD4	5788	920	Gene	Gene	determinations|nmod|START_ENTITY determinations|nsubj|Guidelines Guidelines|acl|performing performing|dobj|T-cell T-cell|compound|END_ENTITY	Guidelines for performing single-platform absolute CD4 + T-cell determinations with CD45 gating for persons infected with human immunodeficiency virus .
1351092	0	CD45	0,4	CD4	53,56	CD45	CD4	19264(Tax:10090)	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	CD45 alternative exon expression in murine and human CD4 + T cell subsets .
1384687	0	CD45	33,37	CD4	149,152	CD45	CD4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	structures|nummod|START_ENTITY expression|nmod|structures expression|dep|epitope epitope|nmod|marker marker|nmod|heterogeneity heterogeneity|nmod|cells cells|compound|END_ENTITY	Differential expression of three CD45 alternative structures on murine T cells : exon 6-dependent epitope as a marker for functional heterogeneity of CD4 + T cells .
14577504	0	CD45	19,23	CD4	38,41	CD45	CD4	5788	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Down regulation of CD45 expression on CD4 T cells during acute renal allograft rejection : evidence of a decline in T suppressor/inducer activity .
1532148	0	CD45	109,113	CD4	15,18	CD45	CD4	5788	920	Gene	Gene	phosphatase|compound|START_ENTITY absence|nmod|phosphatase induces|nmod|absence induces|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of CD4 : lck with the T cell receptor/CD3 complex induces early signaling events in the absence of CD45 tyrosine phosphatase .
1682382	0	CD45	15,19	CD4	52,55	CD45	CD4	5788	920	Gene	Gene	levels|nmod|START_ENTITY expressed|nsubjpass|levels expressed|nmod|END_ENTITY	High levels of CD45 are coordinately expressed with CD4 and CD8 on avian thymocytes .
1716520	0	CD45	0,4	CD4	52,55	CD45	CD4	5788	920	Gene	Gene	isoforms|compound|START_ENTITY associated|nsubj|isoforms associated|nmod|functions functions|nmod|cells cells|nummod|END_ENTITY	CD45 isoforms associated with distinct functions of CD4 cells derived from unusual healthy donors lacking CD45RA - T lymphocytes .
18448457	0	CD45	36,40	CD4	0,3	CD45	CD4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY hyper-responsiveness|nmod|transgenic_mice hyper-responsiveness|compound|END_ENTITY	CD4 + T cell hyper-responsiveness in CD45 transgenic_mice is independent of isoform .
1968425	0	CD45	23,27	CD4	78,81	CD45	CD4	5788	920	Gene	Gene	antibodies|appos|START_ENTITY inhibit|nsubj|antibodies inhibit|dobj|stimulation stimulation|nmod|proliferation proliferation|compound|END_ENTITY	Anti-leucocyte common -LRB- CD45 -RRB- antibodies inhibit dendritic cell stimulation of CD4 and CD8 T-lymphocyte proliferation .
1969461	0	CD45	16,20	CD4	12,15	CD45	CD4	5788	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Decrease of CD4 + CD45 + T-cells in chronic-progressive multiple_sclerosis .
20093141	0	CD45	14,18	CD4	95,98	CD45	CD4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	isoforms|nummod|START_ENTITY Expression|nmod|isoforms correlates|nsubj|Expression correlates|nmod|responses responses|nmod|+ +|compound|END_ENTITY	Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4 + and CD8 + T cells .
2144259	0	CD45	134,138	CD4	7,10	CD45	CD4	5788	920	Gene	Gene	leucocyte_common_antigen|appos|START_ENTITY isoforms|nmod|leucocyte_common_antigen cells|nmod|isoforms cells|nummod|END_ENTITY	Memory CD4 + T cells in man form two distinct subpopulations , defined by their expression of isoforms of the leucocyte_common_antigen , _ CD45 .
26345973	0	CD45	45,49	CD4	40,43	CD45	CD4	5788	920	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Expression and clinical significance of CD4 + CD45 + peripheral blood T cells in patients with ulcerative_colitis .
26345973	0	CD45	45,49	CD4	40,43	CD45	CD4	5788	920	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Expression and clinical significance of CD4 + CD45 + peripheral blood T cells in patients with ulcerative_colitis .
7851017	0	CD45	43,47	CD4	0,3	CD45	CD4	5788	920	Gene	Gene	isoforms|nmod|START_ENTITY defined|nmod|isoforms defined|nsubj|subsets subsets|compound|END_ENTITY	CD4 + T cell subsets defined by isoforms of CD45 in primary_biliary_cirrhosis .
7908636	0	CD45	24,28	CD4	63,66	CD45	CD4	5788	920	Gene	Gene	involvement|nmod|START_ENTITY involvement|acl|signalling signalling|nmod|+ +|compound|END_ENTITY	Distinct involvement of CD45 in antigen receptor signalling in CD4 + and CD8 + primary T cells .
8041724	0	CD45	38,42	CD4	109,112	CD45	CD4	5788	920	Gene	Gene	phosphatase|compound|START_ENTITY domains|nmod|phosphatase Engagement|nmod|domains regulate|nsubj|Engagement regulate|dobj|differentiation differentiation|nmod|thymocytes thymocytes|compound|END_ENTITY	Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4 + CD8 + thymocytes into mature T cells .
8292053	0	CD45	24,28	CD4	54,57	CD45	CD4	5788	920	Gene	Gene	association|nmod|START_ENTITY require|nsubj|association require|dobj|END_ENTITY	The association between CD45 and lck does not require CD4 or CD8 and is independent of T cell receptor stimulation .
8733112	0	CD45	0,4	CD4	28,31	CD45	CD4	5788	920	Gene	Gene	isoforms|nsubj|START_ENTITY isoforms|dobj|expression expression|nmod|+ +|compound|END_ENTITY	CD45 isoforms expression on CD4 + and CD8 + T cells throughout life , from newborns to centenarians : implications for T cell memory .
8757221	0	CD45	0,4	CD4	23,26	CD45	CD4	5788	920	Gene	Gene	isoforms|nsubj|START_ENTITY isoforms|nmod|subsets subsets|compound|END_ENTITY	CD45 isoforms on human CD4 + T-cell subsets .
8946597	0	CD45	0,4	CD4	28,31	CD45	CD4	5788	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	CD45 isoforms expression on CD4 + and CD8 + peripheral blood T-lymphocytes is related to auto-immune processes and hematological manifestations in systemic_lupus_erythematosus .
9366400	0	CD45	65,69	CD4	0,3	CD45	CD4	5788	920	Gene	Gene	cross-linking|compound|START_ENTITY die|dobj|cross-linking induced|xcomp|die induced|nsubjpass|thymocytes thymocytes|compound|END_ENTITY	CD4 + CD8 + thymocytes are preferentially induced to die following CD45 cross-linking , through a novel apoptotic pathway .
9402849	0	CD45	104,108	CD4	121,124	CD45	CD4	5788	920	Gene	Gene	isoforms|nummod|START_ENTITY isoforms|nmod|blood blood|compound|END_ENTITY	Serum levels of interleukin-1_beta , luteinizing hormone , and prolactin correlate with the expression of CD45 isoforms on CD4 + peripheral blood T lymphocytes in healthy women .
9501032	0	CD45	136,140	CD4	129,132	CD45	CD4	5788	920	Gene	Gene	expressing|compound|START_ENTITY determining|nmod|expressing determining|dobj|domain domain|nmod|END_ENTITY	Inhibition of HIV-1 replication by a monoclonal antibody directed toward the complementarity determining region 3-like domain of CD4 in CD45 expressing and CD45-deficient cells .
9874504	0	CD45	43,47	CD4	72,75	CD45	CD4	5788	920	Gene	Gene	isoforms|nummod|START_ENTITY isoforms|acl|circulating circulating|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Distribution of alloreactivity amongst the CD45 isoforms of circulating CD4 and CD8 T lymphocytes .
19726877	0	CD45	133,137	CD43	128,132	CD45	CD43	5788	6693	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	Generation of mature human myelomonocytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34 + CD43 + CD45 + progenitors .
12101203	0	CD45	23,27	CD56	17,21	CD45	CD56	5788	4684	Gene	Gene	Detection|dep|START_ENTITY Detection|nmod|+ +|compound|END_ENTITY	Detection of the CD56 + / CD45 - immunophenotype by flow cytometry in neuroendocrine malignancies .
23126274	0	CD45	28,32	CD56	22,26	CD45	CD56	5788	4684	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Detection of the GD2 + / CD56 + / CD45 - immunophenotype by flow cytometry in cerebrospinal fluids from a patient with retinoblastoma .
11531951	0	CD45	59,63	CD8	111,114	CD45	CD8	5788	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8 + T lymphocytes .
1294962	0	CD45	10,14	CD8	29,32	CD45	CD8	5788	925	Gene	Gene	isoforms|nummod|START_ENTITY isoforms|nmod|END_ENTITY	-LSB- Study of CD45 isoforms on T CD8 lymphocytes , in the peripheral blood and the graft in patients after kidney transplantation -RSB- .
8041724	0	CD45	38,42	CD8	113,116	CD45	CD8	5788	925	Gene	Gene	phosphatase|compound|START_ENTITY domains|nmod|phosphatase Engagement|nmod|domains regulate|nsubj|Engagement regulate|dobj|differentiation differentiation|nmod|thymocytes thymocytes|compound|END_ENTITY	Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4 + CD8 + thymocytes into mature T cells .
9366400	0	CD45	65,69	CD8	5,8	CD45	CD8	5788	925	Gene	Gene	cross-linking|compound|START_ENTITY die|dobj|cross-linking induced|xcomp|die induced|nsubjpass|thymocytes thymocytes|compound|END_ENTITY	CD4 + CD8 + thymocytes are preferentially induced to die following CD45 cross-linking , through a novel apoptotic pathway .
11135579	0	CD45	59,63	CTLA-4	0,6	CD45	CTLA-4	5788	1493	Gene	Gene	mediated|nmod|START_ENTITY tolerance|acl|mediated role|nmod|tolerance plays|dobj|role plays|nsubj|up-regulation up-regulation|compound|END_ENTITY	CTLA-4 up-regulation plays a role in tolerance mediated by CD45 .
22783574	0	CD45	6,10	CTLA-4	11,17	CD45	CTLA-4	5788	1493	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	CD40 , CD45 CTLA-4 levels are elevated in healthy older adults .
19481264	0	CD45	0,4	DOK-1	30,35	CD45	DOK-1	5788	1796	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells .
25047738	0	CD45	31,35	Flk1	18,22	CD45	Flk1	19264(Tax:10090)	16542(Tax:10090)	Gene	Gene	START_ENTITY|dep|Circulating Circulating|dobj|END_ENTITY	Circulating mouse Flk1 + / c-Kit + / CD45 - cells function as endothelial progenitors cells -LRB- EPCs -RRB- and stimulate the growth of human tumor xenografts .
23065155	0	CD45	20,24	Galectin-3	0,10	CD45	Galectin-3	5788	3958	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Galectin-3 binds to CD45 on diffuse large B-cell_lymphoma cells to regulate susceptibility to cell death .
1850360	0	CD45	51,55	Interleukin_2	0,13	CD45	Interleukin 2	19264(Tax:10090)	16183(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Interleukin_2 stimulates serine phosphorylation of CD45 in CTLL-2 .4 cells .
8562955	0	CD45	74,78	Jun_kinase	35,45	CD45	Jun kinase	5788	5601	Gene	Gene	independently|nmod|START_ENTITY independently|compound|END_ENTITY	Fas ligation induces apoptosis and Jun_kinase activation independently of CD45 and Lck in human T cells .
12393728	0	CD45	0,4	Lyn	139,142	CD45	Lyn	19264(Tax:10090)	17096(Tax:10090)	Gene	Gene	phosphatase|nummod|START_ENTITY inhibits|nsubj|phosphatase inhibits|dobj|differentiation differentiation|nmod|cells cells|acl|associated associated|nmod|inactivation inactivation|nmod|END_ENTITY	CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34 + cells associated with selective inactivation of Lyn .
7499277	0	CD45	47,51	Lyn	24,27	CD45	Lyn	5788	4067	Gene	Gene	kinase|nmod|START_ENTITY tyrosine|xcomp|kinase tyrosine|nsubj|regulation regulation|nmod|END_ENTITY	Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells .
12846575	0	CD45	60,64	NF-kappaB	0,9	CD45	NF-kappaB	5788	4790	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|induction induction|amod|END_ENTITY	NF-kappaB induction by bisperoxovanadium compounds requires CD45 , p36 -LRB- LAT -RRB- , PKC , and IKK activity and exhibits kinetics of activation comparable to those of TCR/CD28 coengagement .
7905504	0	CD45	11,15	NF-kappa_B	19,29	CD45	NF-kappa B	5788	4790	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of CD45 on NF-kappa_B .
16616894	0	CD45	51,55	Oct-1	73,78	CD45	Oct-1	19264(Tax:10090)	18986(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY transcription|nsubj|regulation transcription|nmod|END_ENTITY	Differential lineage-specific regulation of murine CD45 transcription by Oct-1 and PU .1 .
12810785	0	CD45	23,27	PTPRC	16,21	CD45	PTPRC	5788	5788	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The role of the PTPRC -LRB- CD45 -RRB- mutation in the development of multiple_sclerosis in the North West region of the United Kingdom .
18634151	0	CD45	84,88	PTPRC	77,82	CD45	PTPRC	5788	5788	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No association between systemic_sclerosis and C77G polymorphism in the human PTPRC -LRB- CD45 -RRB- gene .
21323873	0	CD45	134,138	PTPRC	127,132	CD45	PTPRC	5788	5788	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Outcome of children treated with haematopoietic-stem cell transplantations from donors expressing the rare C77G variant of the PTPRC -LRB- CD45 -RRB- gene .
10092085	0	CD45	28,32	SF2	0,3	CD45	SF2	5788	6426	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation .
8475386	0	CD45	31,35	TCR	14,17	CD45	TCR	19264(Tax:10090)	328483(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains .
1400466	0	CD45	42,46	Tyrosine_phosphatase	0,20	CD45	Tyrosine phosphatase	19264(Tax:10090)	13924(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tyrosine_phosphatase activity of lymphoma CD45 -LRB- GP180 -RRB- is regulated by a direct interaction with the cytoskeleton .
8557683	0	CD45	47,51	insulin_receptor	81,97	CD45	insulin receptor	5788	3643	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin_receptor signaling .
14979481	0	CD45	33,37	interleukin_6	54,67	CD45	interleukin 6	5788	3569	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The protein tyrosine phosphatase CD45 is required for interleukin_6 signaling in U266 myeloma cells .
10415030	0	CD45	0,4	lyn	26,29	CD45	lyn	19264(Tax:10090)	17096(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells .
12207342	0	CD45	13,17	protein_tyrosine_phosphatase	18,46	CD45	protein tyrosine phosphatase	5788	26191	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Targeting of CD45 protein_tyrosine_phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling .
7533193	0	CD45	34,38	protein_tyrosine_phosphatase	39,67	CD45	protein tyrosine phosphatase	5788	26191	Gene	Gene	activity|nummod|START_ENTITY activity|compound|END_ENTITY	Non-radioactive method to measure CD45 protein_tyrosine_phosphatase activity isolated directly from cells .
8766549	0	CD45	64,68	tumor_necrosis_factor-alpha	77,104	CD45	tumor necrosis factor-alpha	5788	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Epitope-specific engagement of the protein tyrosine phosphatase CD45 induces tumor_necrosis_factor-alpha gene expression via transcriptional mechanisms .
16771860	0	CD45	0,4	tumour_necrosis_factor	26,48	CD45	tumour necrosis factor	19264(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	CD45 negatively regulates tumour_necrosis_factor and interleukin-6 production in dendritic cells .
11385612	0	CD45R	20,25	CD4	44,47	CD45R	CD4	5788	920	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Both CD45R -LRB- low -RRB- and CD45R -LRB- high -RRB- `` revertant '' CD4 memory T cells provide help for memory B cells .
1388189	0	CD45R	54,59	CD4	28,31	CD45R	CD4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY differing|nmod|expression requirements|acl|differing requirements|nmod|cells cells|compound|END_ENTITY	Activation requirements for CD4 + T cells differing in CD45R expression .
1533900	0	CD45R	38,43	CD4	34,37	CD45R	CD4	5788	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Antilymphocyte antibodies against CD4 + CD45R + subsets in patients with IgA_nephropathy .
1534263	0	CD45R	54,59	CD4	12,15	CD45R	CD4	5788	920	Gene	Gene	isoforms|nummod|START_ENTITY expression|nmod|isoforms Function|dep|expression Function|nmod|subsets subsets|compound|END_ENTITY	Function of CD4 T cell subsets in vivo : expression of CD45R isoforms .
15493262	0	CD45R	88,93	CD4	76,79	CD45R	CD4	5788	920	Gene	Gene	CDw29|dep|START_ENTITY CDw29|compound|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
1827080	1	CD45R	94,99	CD4	90,93	CD45R	CD4	5788	920	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|compound|END_ENTITY	Association of insulin autoantibodies with CD4 + CD45R + lymphocyte subpopulation in prediabetic subjects .
1836161	0	CD45R	8,13	CD4	90,93	CD45R	CD4	5788	920	Gene	Gene	expression|compound|START_ENTITY affects|nsubj|expression affects|dobj|helper/inducer helper/inducer|appos|+ +|compound|END_ENTITY	Variant CD45R expression with autosomal dominant inheritance affects both helper/inducer -LRB- CD4 + -RRB- and suppressor/cytotoxic -LRB- CD8 + -RRB- T cell populations .
1967994	0	CD45R	22,27	CD4	17,20	CD45R	CD4	5788	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Immunoregulatory CD4 + CD45R + suppressor/inducer T lymphocyte subsets and impaired cell-mediated immunity in patients with Down 's _ syndrome .
1978760	0	CD45R	29,34	CD4	44,47	CD45R	CD4	5788	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	-LSB- HLA-DR positive T cells and CD45R positive CD4 cells in primary Sj gren 's syndrome -RSB- .
2346723	0	CD45R	20,25	CD4	70,73	CD45R	CD4	5788	920	Gene	Gene	distribution|nmod|START_ENTITY antigens|nsubj|distribution antigens|nmod|T-cell_leukaemias T-cell_leukaemias|compound|END_ENTITY	The distribution of CD45R , CD29 and CD45RO -LRB- UCHL1 -RRB- antigens in mature CD4 positive T-cell_leukaemias .
2479465	0	CD45R	34,39	CD4	30,33	CD45R	CD4	5788	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Depletion of T-cells with the CD4 + CD45R + phenotype in lymphocytes that infiltrate subcutaneous metastases of human melanoma .
2524299	0	CD45R	37,42	CD4	50,53	CD45R	CD4	5788	920	Gene	Gene	START_ENTITY|nmod|helper/inducer helper/inducer|compound|END_ENTITY	Predominance of T cells that express CD45R in the CD4 + helper/inducer lymphocyte subset of neonates .
2525435	0	CD45R	33,38	CD4	84,87	CD45R	CD4	5788	920	Gene	Gene	augmentation|nmod|START_ENTITY +|nsubj|augmentation +|dobj|subset subset|nmod|subset subset|compound|END_ENTITY	Concomitant augmentation of CD4 + CD45R + suppressor/inducer subset and diminution of CD4 + CDw29 + helper/inducer subset during rush hyposensitization in hymenoptera venom allergy .
2567241	0	CD45R	32,37	CD4	52,55	CD45R	CD4	19264(Tax:10090)	12504(Tax:10090)	Gene	Gene	antibody|nmod|START_ENTITY distinguishes|nsubj|antibody distinguishes|dobj|populations populations|compound|END_ENTITY	A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines .
2968811	0	CD45R	20,25	CD4	140,143	CD45R	CD4	5788	920	Gene	Gene	antigen|compound|START_ENTITY Distribution|nmod|antigen finding|nsubj|Distribution finding|nmod|lymphoproliferative_disorders lymphoproliferative_disorders|compound|END_ENTITY	Distribution of the CD45R antigen in the maturation of lymphoid and myeloid series : the CD45R negative phenotype is a constant finding in T CD4 positive lymphoproliferative_disorders .
2968811	0	CD45R	88,93	CD4	140,143	CD45R	CD4	5788	920	Gene	Gene	phenotype|compound|START_ENTITY series|dep|phenotype maturation|nmod|series antigen|nmod|maturation Distribution|nmod|antigen finding|nsubj|Distribution finding|nmod|lymphoproliferative_disorders lymphoproliferative_disorders|compound|END_ENTITY	Distribution of the CD45R antigen in the maturation of lymphoid and myeloid series : the CD45R negative phenotype is a constant finding in T CD4 positive lymphoproliferative_disorders .
2970472	0	CD45R	23,28	CD4	18,21	CD45R	CD4	5788	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Selective loss of CD4 + CD45R + T cells in peripheral blood of multiple_myeloma patients .
7507305	0	CD45R	71,76	CD4	33,36	CD45R	CD4	5788	920	Gene	Gene	antibodies|compound|START_ENTITY using|dobj|antibodies atopic_dermatitis|xcomp|using atopic_dermatitis|nsubj|Characterization Characterization|acl|infiltrating infiltrating|dobj|cells cells|nummod|END_ENTITY	Characterization of infiltrating CD4 + cells in atopic_dermatitis using CD45R and CD29 monoclonal antibodies .
1345895	0	CD45R	12,17	CD8	39,42	CD45R	CD8	5788	925	Gene	Gene	Reversal|nmod|START_ENTITY isoform|nsubj|Reversal isoform|xcomp|switching switching|nmod|cells cells|compound|END_ENTITY	Reversal of CD45R isoform switching in CD8 + T cells .
2482844	0	CD45R	29,34	CD8	44,47	CD45R	CD8	5788	925	Gene	Gene	loss|appos|START_ENTITY HLA-DR|nsubj|loss HLA-DR|dobj|subsets subsets|compound|END_ENTITY	Preferential loss of Leu_8 - , CD45R , HLA-DR + CD8 cell subsets during in vitro culture of mononuclear cells from human_immunodeficiency_virus_type_I -LRB- HIV -RRB- - seropositive former blood donors .
2532577	0	CD45R	28,33	CD8	24,27	CD45R	CD8	5788	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of the CD8 + CD45R + -LRB- 2H4 + -RRB- suppressor effector cell .
2567246	0	CD45R	35,40	CD8	59,62	CD45R	CD8	5788	925	Gene	Gene	molecule|compound|START_ENTITY molecule|nmod|cells cells|amod|END_ENTITY	Functional characterization of the CD45R -LRB- 2H4 -RRB- molecule on CD8 -LRB- T8 -RRB- cells in the autologous mixed lymphocyte reaction system .
2346723	0	CD45R	20,25	UCHL1	44,49	CD45R	UCHL1	5788	7345	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of CD45R , CD29 and CD45RO -LRB- UCHL1 -RRB- antigens in mature CD4 positive T-cell_leukaemias .
23747721	0	CD45RA-CD27	71,82	CCR7	64,68	CD45RA-CD27	CCR7	939	1236	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD45RA-Foxp3 -LRB- high -RRB- activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28 + central memory subset are decreased in peripheral blood from patients with rheumatoid_arthritis .
23747721	0	CD45RA-CD27	71,82	CD28	85,89	CD45RA-CD27	CD28	939	940	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	CD45RA-Foxp3 -LRB- high -RRB- activated/effector regulatory T cells in the CCR7 + CD45RA-CD27 + CD28 + central memory subset are decreased in peripheral blood from patients with rheumatoid_arthritis .
20921150	0	CD46	0,4	CD4	25,28	CD46	CD4	4179	920	Gene	Gene	engagement|nummod|START_ENTITY engagement|nmod|cells cells|compound|END_ENTITY	CD46 engagement on human CD4 + T cells produces T regulatory type 1-like regulation of antimycobacterial T cell responses .
11714708	0	CD46	33,37	DLG4	59,63	CD46	DLG4	4179	1742	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|role role|nmod|END_ENTITY	A functional interaction between CD46 and DLG4 : a role for DLG4 in epithelial polarization .
22293503	0	CD46	18,22	HBXIP	0,5	CD46	HBXIP	4179	10542	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	HBXIP upregulates CD46 , CD55 and CD59 through ERK1/2/NF-kB signaling to protect breast_cancer cells from complement attack .
18403025	0	CD46	83,87	IL-23	10,15	CD46	IL-23	4179	51561	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple_sclerosis .
10211099	0	CD46	90,94	interferon-gamma	29,45	CD46	interferon-gamma	4179	3458	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation by interferon-gamma of the membrane-bound complement regulators CD46 -LRB- MCP -RRB- , CD55 -LRB- DAF -RRB- and CD59 in gastrointestinal_tumours .
10361248	0	CD46	60,64	membrane_cofactor_protein	33,58	CD46	membrane cofactor protein	4179	4179	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated serum levels of soluble membrane_cofactor_protein -LRB- CD46 , MCP -RRB- in patients with systemic_lupus_erythematosus -LRB- SLE -RRB- .
10779410	0	CD46	16,20	membrane_cofactor_protein	22,47	CD46	membrane cofactor protein	4179	4179	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Urine levels of CD46 -LRB- membrane_cofactor_protein -RRB- are increased in patients with glomerular_diseases .
7691939	0	CD46	74,78	membrane_cofactor_protein	47,72	CD46	membrane cofactor protein	4179	4179	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the promoter region of the membrane_cofactor_protein -LRB- CD46 -RRB- gene of the human complement system and comparison to a membrane_cofactor_protein-like genetic element .
17699108	0	CD46	81,85	signal_transducers_and_activators_of_transcription_3	10,62	CD46	signal transducers and activators of transcription 3	4179	6774	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Activated signal_transducers_and_activators_of_transcription_3 signaling induces CD46 expression and protects human cancer cells from complement-dependent cytotoxicity .
16131383	0	CD47	171,175	CD47	94,98	CD47	CD47	961	961	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	The application of a new quantitative assay for the monitoring of integrin-associated protein CD47 on red blood cells during storage and comparison with the expression of CD47 and phosphatidylserine with flow cytometry .
16131383	0	CD47	94,98	CD47	171,175	CD47	CD47	961	961	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The application of a new quantitative assay for the monitoring of integrin-associated protein CD47 on red blood cells during storage and comparison with the expression of CD47 and phosphatidylserine with flow cytometry .
10891456	0	CD47	28,32	CDC42	89,94	CD47	CDC42	961	998	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Integrin-associated_protein / CD47 regulates motile activity in human B-cell lines through CDC42 .
26512116	0	CD47	16,20	HIF-1	0,5	CD47	HIF-1	961	3091	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HIF-1 regulates CD47 expression in breast_cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells .
10891456	0	CD47	28,32	Integrin-associated_protein	0,27	CD47	Integrin-associated protein	961	961	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Integrin-associated_protein / CD47 regulates motile activity in human B-cell lines through CDC42 .
26966191	0	CD47	52,56	MYC	0,3	CD47	MYC	961	4609	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MYC regulates the antitumor immune response through CD47 and PD-L1 .
23087362	0	CD47	42,46	NADPH_oxidase_1	79,94	CD47	NADPH oxidase 1	961	27035	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH_oxidase_1 .
10725722	0	CD47	72,76	SHPS-1	0,6	CD47	SHPS-1	16423(Tax:10090)	19261(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY cells|nmod|interaction aggregation|nmod|cells induces|dobj|aggregation induces|nsubj|END_ENTITY	SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47 .
15842360	0	CD47	68,72	SHPS-1	0,6	CD47	SHPS-1	16423(Tax:10090)	19261(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	SHPS-1 negatively regulates integrin alphaIIbbeta3 function through CD47 without disturbing FAK phosphorylation .
21638321	0	CD47	41,45	SHPS-1	49,55	CD47	SHPS-1	16423(Tax:10090)	19261(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY role|nmod|association role|nmod|END_ENTITY	An essential role for the association of CD47 to SHPS-1 in skeletal remodeling .
24269920	0	CD47	70,74	SIRPA	32,37	CD47	SIRPA	961	140885	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47 , inhibiting phagocytosis against human cells to promote xenogeneic engraftment .
21535911	0	CD47	127,131	SIRPa	93,98	CD47	SIRPa	961	19261(Tax:10090)	Gene	Gene	express|nmod|START_ENTITY express|xcomp|capable capable|nsubj|END_ENTITY	Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPa capable of binding to human CD47 .
21535911	0	CD47	6,10	SIRPa	93,98	CD47	SIRPa	16423(Tax:10090)	19261(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY permits|nsubj|expression permits|dobj|survival survival|acl:relcl|express express|xcomp|capable capable|nsubj|END_ENTITY	Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPa capable of binding to human CD47 .
22511785	0	CD47	145,149	SIRPa	99,104	CD47	SIRPa	961	140885	Gene	Gene	domain|nmod|START_ENTITY site|nmod|domain signal_regulatory_protein_a|appos|site signal_regulatory_protein_a|appos|END_ENTITY	Surfactant_protein_D -LRB- Sp-D -RRB- binds to membrane-proximal domain -LRB- D3 -RRB- of signal_regulatory_protein_a -LRB- SIRPa -RRB- , a site distant from binding domain of CD47 , while also binding to analogous region on signal regulatory protein b -LRB- SIRPb -RRB- .
23472187	0	CD47	24,28	SIRPa	110,115	CD47	SIRPa	29364(Tax:10116)	25528(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY prevents|nsubj|Expression prevents|nmod|END_ENTITY	Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPa inhibitory signaling in mice .
23801922	0	CD47	8,12	SIRPa	50,55	CD47	SIRPa	961	140885	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of CD47 and Signal_Regulatory_Protein_Alpha -LRB- SIRPa -RRB- in Regulating the Clearance of Viable or Aged Blood Cells .
23990469	0	CD47	8,12	SIRPa	139,144	CD47	SIRPa	16423(Tax:10090)	19261(Tax:10090)	Gene	Gene	Lack|nmod|START_ENTITY impairs|nsubj|Lack impairs|xcomp|due due|nmod|signal_regulatory_protein_a signal_regulatory_protein_a|appos|END_ENTITY	Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal_regulatory_protein_a -LRB- SIRPa -RRB- signaling .
24073274	0	CD47	6,10	SIRPa	12,17	CD47	SIRPa	961	140885	Gene	Gene	START_ENTITY|dep|mechanism mechanism|compound|END_ENTITY	Novel CD47 : SIRPa dependent mechanism for the activation of STAT3 in antigen-presenting cell .
24143245	0	CD47	167,171	SIRPa	13,18	CD47	SIRPa	961	140885	Gene	Gene	mediate|nmod|START_ENTITY required|xcomp|mediate membrane|ccomp|required membrane|nsubj|END_ENTITY	` Clustering ' SIRPa into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47 .
25305319	0	CD47	58,62	SIRPa	43,48	CD47	SIRPa	16423(Tax:10090)	19261(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|Polymorphism Polymorphism|nmod|END_ENTITY	Polymorphism in the innate immune receptor SIRPa controls CD47 binding and autoimmunity in the nonobese diabetic mouse .
25837251	0	CD47	38,42	SIRPa	86,91	CD47	SIRPa	961	140885	Gene	Gene	Ectodomain|compound|START_ENTITY Engineering|nmod|Ectodomain Engineering|appos|END_ENTITY	`` Velcro '' Engineering of High Affinity CD47 Ectodomain as Signal_Regulatory_Protein_a -LRB- SIRPa -RRB- Antagonists That Enhance Antibody-dependent Cellular Phagocytosis .
26085683	0	CD47	21,25	SIRPa	70,75	CD47	SIRPa	961	140885	Gene	Gene	Formation|compound|START_ENTITY Formation|nmod|Clearance Clearance|compound|END_ENTITY	Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPa Facilitate Apoptotic Cell Clearance by Macrophages .
11313266	0	CD47	104,108	SIRPalpha	33,42	CD47	SIRPalpha	961	140885	Gene	Gene	binds|nmod|START_ENTITY binds|ccomp|involved involved|nsubjpass|Signal-regulatory_protein_alpha Signal-regulatory_protein_alpha|appos|END_ENTITY	Signal-regulatory_protein_alpha -LRB- SIRPalpha -RRB- but not SIRPbeta is involved in T-cell activation , binds to CD47 with high affinity , and is expressed on immature CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- hematopoietic cells .
17070842	0	CD47	76,80	SIRPalpha	23,32	CD47	SIRPalpha	961	140885	Gene	Gene	binding|nmod|START_ENTITY surface|xcomp|binding surface|nsubj|elements elements|nmod|cell cell|compound|END_ENTITY	Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47 .
19223164	0	CD47	44,48	SIRPalpha	33,42	CD47	SIRPalpha	961	140885	Gene	Gene	interaction|amod|START_ENTITY /|dobj|interaction /|nsubj|Signal_regulatory_protein_alpha Signal_regulatory_protein_alpha|appos|END_ENTITY	Signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- / CD47 interaction and function .
19703989	0	CD47	11,15	SIRPalpha	71,80	CD47	SIRPalpha	16423(Tax:10090)	19261(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY mediated|nsubj|role mediated|nmod|CD103 CD103|compound|END_ENTITY	A role for CD47 in the development of experimental colitis mediated by SIRPalpha + CD103 - dendritic cells .
20826801	0	CD47	90,94	SIRPalpha	65,74	CD47	SIRPalpha	961	140885	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of cis dimerization of signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- in binding to CD47 .
19223164	0	CD47	44,48	Signal_regulatory_protein_alpha	0,31	CD47	Signal regulatory protein alpha	961	140885	Gene	Gene	interaction|amod|START_ENTITY /|dobj|interaction /|nsubj|END_ENTITY	Signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- / CD47 interaction and function .
21712621	0	CD47	0,4	TGF-b	19,24	CD47	TGF-b	16423(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	CD47 regulates the TGF-b signaling pathway in osteoblasts and is distributed in Meckel 's cartilage .
19952644	0	CD47	17,21	Thrombospondin-1	0,16	CD47	Thrombospondin-1	29364(Tax:10116)	445442(Tax:10116)	Gene	Gene	ischemia-reperfusion_injury|compound|START_ENTITY ischemia-reperfusion_injury|nummod|END_ENTITY	Thrombospondin-1 / CD47 blockade following ischemia-reperfusion_injury is tissue protective .
20923780	0	CD47	87,91	Thrombospondin-1	0,16	VEGF	Thrombospondin-1	7422	7057	Gene	Gene	disrupting|nmod|START_ENTITY signaling|advcl|disrupting VEGF_receptor-2|acl|signaling inhibits|dobj|VEGF_receptor-2 inhibits|nsubj|END_ENTITY	Thrombospondin-1 inhibits VEGF_receptor-2 signaling by disrupting its association with CD47 .
23087362	0	CD47	42,46	Thrombospondin-1	0,16	CD47	Thrombospondin-1	961	7057	Gene	Gene	activation|nummod|START_ENTITY flow|nmod|activation regulates|dobj|flow regulates|nsubj|END_ENTITY	Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH_oxidase_1 .
23591719	0	CD47	35,39	Thrombospondin-1	0,16	CD47	Thrombospondin-1	16423(Tax:10090)	21825(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors .
25697354	0	CD47	156,160	Thrombospondin-1	121,137	CD47	thrombospondin-1	961	7057	Gene	Gene	Protein|compound|START_ENTITY Blocked|nmod|Protein Blocked|nmod|Signaling Signaling|compound|END_ENTITY	Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape , Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein .
26813769	0	CD47	96,100	Thrombospondin-1	9,25	CD47	Thrombospondin-1	961	7057	Gene	Gene	Interleukin-1b|nmod|START_ENTITY Interleukin-1b|nsubj|Macrophage Macrophage|compound|END_ENTITY	Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1b Production and Activation through CD47 .
19636412	0	CD47	0,4	cyclooxygenase-2	34,50	CD47	cyclooxygenase-2	961	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration .
12509218	0	CD47	14,18	integrin-associated_protein	20,47	CD47	integrin-associated protein	961	961	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD47 -LRB- integrin-associated_protein -RRB- decreases on red blood cells during storage .
14747477	0	CD47	80,84	integrin-associated_protein	52,79	CD47	integrin-associated protein	961	961	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Alpha-Pal/NRF -1 regulates the promoter of the human integrin-associated_protein / CD47 gene .
10964914	0	CD47	0,4	macrophage_fusion_receptor	23,49	CD47	macrophage fusion receptor	961	140885	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	CD47 , a ligand for the macrophage_fusion_receptor , participates in macrophage multinucleation .
14764731	0	CD47	69,73	signal_regulatory_protein_alpha	92,123	CD47	signal regulatory protein alpha	961	140885	Gene	Gene	interactions|nummod|START_ENTITY blocking|dobj|interactions blocking|nmod|END_ENTITY	Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal_regulatory_protein_alpha .
17098740	0	CD47	27,31	signal_regulatory_protein_alpha	56,87	CD47	signal regulatory protein alpha	961	140885	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	Phylogenetic divergence of CD47 interactions with human signal_regulatory_protein_alpha reveals locus of species specificity .
20826801	0	CD47	90,94	signal_regulatory_protein_alpha	32,63	CD47	signal regulatory protein alpha	961	140885	Gene	Gene	role|nmod|START_ENTITY role|nmod|dimerization dimerization|nmod|END_ENTITY	The role of cis dimerization of signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- in binding to CD47 .
12924949	0	CD47	63,67	thrombospondin-1	37,53	CD47	thrombospondin-1	961	7057	Gene	Gene	START_ENTITY|nsubj|domain domain|nmod|displays displays|amod|END_ENTITY	An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs .
16835222	0	CD47	0,4	thrombospondin-1	87,103	CD47	thrombospondin-1	16423(Tax:10090)	21825(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|advcl|END_ENTITY	CD47 is necessary for inhibition of nitric_oxide-stimulated vascular cell responses by thrombospondin-1 .
17916772	0	CD47	26,30	thrombospondin-1	9,25	CD47	thrombospondin-1	16423(Tax:10090)	21825(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY alleviates|nsubj|signaling END_ENTITY|parataxis|alleviates	Blocking thrombospondin-1 / CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia .
18438125	0	CD47	18,22	thrombospondin-1	48,64	CD47	thrombospondin-1	961	7057	Gene	Gene	ligation|compound|START_ENTITY Gene|nmod|ligation Gene|nmod|survival survival|amod|END_ENTITY	Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model : implications for human disease .
18855617	0	CD47	68,72	thrombospondin-1	51,67	CD47	thrombospondin-1	16423(Tax:10090)	21825(Tax:10090)	Gene	Gene	START_ENTITY|dep|Enhancing Enhancing|nmod|inhibition inhibition|nmod|END_ENTITY	Enhancing cardiovascular dynamics by inhibition of thrombospondin-1 / CD47 signaling .
19081017	0	CD47	76,80	thrombospondin-1	59,75	CD47	thrombospondin-1	16423(Tax:10090)	21825(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY Treatment|parataxis|signaling Treatment|nmod|injury injury|acl|limiting limiting|xcomp|END_ENTITY	Treatment of liver_ischemia-reperfusion injury by limiting thrombospondin-1 / CD47 signaling .
21343308	0	CD47	59,63	thrombospondin-1	124,140	CD47	thrombospondin-1	961	7057	Gene	Gene	modification|nmod|START_ENTITY necessary|nsubj|modification necessary|xcomp|signaling signaling|advcl|END_ENTITY	Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1 .
22266027	0	CD47	114,118	thrombospondin-1	26,42	CD47	thrombospondin-1	16423(Tax:10090)	21825(Tax:10090)	Gene	Gene	stress|nmod|START_ENTITY regulates|nmod|stress regulates|nsubj|END_ENTITY	The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47 .
25779848	0	CD47	55,59	thrombospondin-1	29,45	CD47	thrombospondin-1	16423(Tax:10090)	21825(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targeting targeting|nmod|receptor receptor|amod|END_ENTITY	Therapeutic targeting of the thrombospondin-1 receptor CD47 to treat liver_cancer .
20364320	0	CD47	83,87	vascular_endothelial_growth_factor	13,47	CD47	vascular endothelial growth factor	961	7422	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor and matrix_metalloproteinase-9 via CD47 signaling in neurovascular cells .
15870174	0	CD48	12,16	2B4	0,3	CD48	2B4	12506(Tax:10090)	18106(Tax:10090)	Gene	Gene	interactions|nummod|START_ENTITY END_ENTITY|dep|interactions	2B4 -LRB- CD244 -RRB- - CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice .
9841922	0	CD48	95,99	2B4	0,3	CD48	2B4	962	51744	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	2B4 , the natural killer and T cell immunoglobulin superfamily surface protein , is a ligand for CD48 .
1848579	0	CD48	81,85	Blast-1	18,25	CD48	Blast-1	962	962	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|molecule molecule|compound|END_ENTITY	Expression of the Blast-1 activation/adhesion molecule and its identification as CD48 .
1999350	0	CD48	28,32	Blast-1	87,94	CD48	Blast-1	962	962	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	The human leucocyte antigen CD48 -LRB- MEM-102 -RRB- is closely related to the activation marker Blast-1 .
1383383	0	CD48	0,4	CD2	37,40	CD48	CD2	12506(Tax:10090)	12481(Tax:10090)	Gene	Gene	counter-receptor|nsubj|START_ENTITY counter-receptor|nmod|END_ENTITY	CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation .
8104993	1	CD48	92,96	CD2	113,116	CD48	CD2	12506(Tax:10090)	12481(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Demonstration that CD48 is a ligand for CD2 and that CD48 adhesion is regulated by CD2 .
8025956	0	CD49A	26,31	VLA-1	19,24	CD49A	VLA-1	3672	3672	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Functional role of VLA-1 -LRB- CD49A -RRB- in adhesion , cation-dependent spreading , and activation of cultured human T lymphocytes .
23160057	0	CD49b	30,35	CD29	61,65	CD49b	CD29	3673	3688	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of a -LRB- CD49b -RRB- , a -LRB- CD49d -RRB- and b -LRB- CD29 -RRB- integrin subunits on peripheral blood T lymphocytes in clinically stable mild-to-moderate persistent asthma .
26590312	0	CD49b	17,22	CD4	13,16	CD49b	CD4	3673	920	Gene	Gene	Cells|compound|START_ENTITY +|dobj|Cells +|nsubj|END_ENTITY	Nonclassical CD4 + CD49b + Regulatory T Cells as a Better Alternative to Conventional CD4 + CD25 + T Cells To Dampen Arthritis Severity .
19228923	0	CD49d	75,80	CXCR4	50,55	CD49d	CXCR4	3676	7852	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Mantle_cell_lymphoma cells express high levels of CXCR4 , CXCR5 , and VLA-4 -LRB- CD49d -RRB- : importance for interactions with the stromal microenvironment and specific targeting .
26559905	0	CD49d	0,5	ITGA4	7,12	CD49d	ITGA4	3676	3676	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD49d -LRB- ITGA4 -RRB- expression is a predictor of time to first treatment in patients with chronic_lymphocytic_leukaemia and mutated IGHV status .
18818395	0	CD49f	49,54	PODXL	22,27	CD49f	PODXL	16403(Tax:10090)	27205(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The CD34-like protein PODXL and alpha6-integrin -LRB- CD49f -RRB- identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice .
11861604	0	CD5	61,64	B-1	25,28	CD5	B-1	921	931	Gene	Gene	role|nmod|START_ENTITY notes|nmod|role Origins|nmod|notes Origins|nmod|cells cells|amod|END_ENTITY	Origins and functions of B-1 cells with notes on the role of CD5 .
12070149	0	CD5	11,14	B-1	16,19	CD5	B-1	921	931	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Peritoneal CD5 + B-1 cells have signaling properties similar to tolerant B cells .
1377947	0	CD5	58,61	B-1	53,56	CD5	B-1	921	931	Gene	Gene	B|compound|START_ENTITY cells|appos|B cells|amod|END_ENTITY	The ontogeny and functional characteristics of human B-1 -LRB- CD5 + B -RRB- cells .
8826882	0	CD5	13,16	BCL-2	44,49	CD5	BCL-2	921	596	Gene	Gene	cells|compound|START_ENTITY shifted|nmod|cells shifted|nsubjpass|expression expression|nmod|family family|compound|END_ENTITY	In leukaemic CD5 + B cells the expression of BCL-2 gene family is shifted toward protection from apoptosis .
9359515	0	CD5	59,62	Bcl-2	37,42	CD5	Bcl-2	921	596	Gene	Gene	cells|nummod|START_ENTITY product|nmod|cells product|compound|END_ENTITY	Fludarabine ability to down-regulate Bcl-2 gene product in CD5 + leukaemic B cells : in vitro/in vivo correlations .
10482997	0	CD5	83,86	CD10	93,97	CD5	CD10	921	4311	Gene	Gene	START_ENTITY|nmod|groups groups|nummod|+ +|compound|END_ENTITY	Molecular and immunological dissection of diffuse large B_cell_lymphoma : CD5 + , and CD5 - with CD10 + groups may constitute clinically relevant subtypes .
11925876	0	CD5	1,4	CD10	6,10	CD5	CD10	921	4311	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- CD5 + CD10 + extranodal B-cell_lymphoma with tetraploid_chromosomal_abnormality -RSB- .
15272540	0	CD5	91,94	CD10	122,126	CD5	CD10	921	4311	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression case|nmod|loss case|nmod|END_ENTITY	An unusual case of leukemic mantle_cell_lymphoma with a blastoid_component showing loss of CD5 and aberrant expression of CD10 .
17875529	0	CD5	35,38	CD10	39,43	CD5	CD10	921	4311	Gene	Gene	B-cell_lymphoma|compound|START_ENTITY B-cell_lymphoma|compound|END_ENTITY	t -LRB- 6 ; 14 -RRB- -LRB- q15 ; q32 -RRB- in a patient with CD5 + CD10 + diffuse large B-cell_lymphoma .
18684040	0	CD5	55,58	CD10	60,64	CD5	CD10	921	4311	Gene	Gene	case|nmod|START_ENTITY case|parataxis|+ +|compound|END_ENTITY	A unique case of mantle_cell_lymphoma with an aberrant CD5 - / CD10 + immunophenotype and typical morphology .
20379114	0	CD5	34,37	CD10	39,43	CD5	CD10	921	4311	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Marfan_syndrome complicated with CD5 + CD10 + diffuse_large_B-cell_lymphoma -RSB- .
23052175	0	CD5	75,78	CD10	80,84	CD5	CD10	921	4311	Gene	Gene	case|nmod|START_ENTITY case|parataxis|+ +|compound|END_ENTITY	A unique case of blastoid variant of mantle_cell_lymphoma with an aberrant CD5 - / CD10 + / Bcl-6 + / CD56 + immunophenotype : a case report .
18546943	0	CD5	38,41	CD19	33,37	CD5	CD19	921	930	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Evaluation of percentage of the CD19 + CD5 + lymphocytes in hypertrophied adenoids at children with otitis media with effusion -RSB- .
21286386	0	CD5	109,112	CD19	102,106	CD5	CD19	921	930	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|nummod|END_ENTITY	Presence of Foxp3-expressing CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- B Cells in Human Peripheral Blood Mononuclear Cells : Human CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory B Cell -LRB- Breg -RRB- .
21286386	0	CD5	109,112	CD19	29,33	CD5	CD19	921	930	Gene	Gene	Foxp3|compound|START_ENTITY Presence|dep|Foxp3 Presence|nmod|CD5 CD5|compound|END_ENTITY	Presence of Foxp3-expressing CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- B Cells in Human Peripheral Blood Mononuclear Cells : Human CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory B Cell -LRB- Breg -RRB- .
21286386	0	CD5	36,39	CD19	102,106	CD5	CD19	921	930	Gene	Gene	Presence|nmod|START_ENTITY Presence|dep|Foxp3 Foxp3|nummod|END_ENTITY	Presence of Foxp3-expressing CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- B Cells in Human Peripheral Blood Mononuclear Cells : Human CD19 -LRB- + -RRB- CD5 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory B Cell -LRB- Breg -RRB- .
21786452	0	CD5	148,151	CD19	120,124	CD5	CD19	921	930	Gene	Gene	B|compound|START_ENTITY subpopulations|nmod|B subpopulations|amod|END_ENTITY	IL-10 is predominantly produced by CD19 -LRB- low -RRB- CD5 -LRB- + -RRB- regulatory B cell subpopulation : characterisation of CD19 -LRB- high -RRB- and CD19 -LRB- low -RRB- subpopulations of CD5 -LRB- + -RRB- B cells .
21786452	0	CD5	44,47	CD19	104,108	CD5	CD19	921	930	Gene	Gene	START_ENTITY|dep|characterisation characterisation|nmod|END_ENTITY	IL-10 is predominantly produced by CD19 -LRB- low -RRB- CD5 -LRB- + -RRB- regulatory B cell subpopulation : characterisation of CD19 -LRB- high -RRB- and CD19 -LRB- low -RRB- subpopulations of CD5 -LRB- + -RRB- B cells .
23409986	0	CD5	15,18	CD19	19,23	CD5	CD19	921	930	Gene	Gene	Cell|compound|START_ENTITY Cell|compound|END_ENTITY	Involvement of CD5 + CD19 + Cell in steroid-dependent nephrotic_syndrome treated with B-cell targeting therapy .
23507469	0	CD5	5,8	CD19	0,4	CD5	CD19	921	930	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD19 + CD5 + B cells and B1-like cells following allogeneic hematopoietic stem cell transplantation .
25516754	0	CD5	30,33	CD19	25,29	CD5	CD19	12507(Tax:10090)	12478(Tax:10090)	Gene	Gene	CD1dhiIL-10|compound|START_ENTITY CD1dhiIL-10|compound|END_ENTITY	Critical role for thymic CD19 + CD5 + CD1dhiIL-10 + regulatory B cells in immune homeostasis .
9451471	0	CD5	10,13	CD19	14,18	CD5	CD19	921	930	Gene	Gene	B|compound|START_ENTITY B|compound|END_ENTITY	Increased CD5 + CD19 + B lymphocytes at the onset of type 1 diabetes in children .
11981840	0	CD5	31,34	CD2	0,3	CD5	CD2	54236(Tax:10116)	497761(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains .
16867907	0	CD5	34,37	CD20	99,103	CD5	CD20	921	54474	Gene	Gene	+|compound|START_ENTITY relapse|nmod|+ intravascular|nsubj|relapse intravascular|nmod|down-modulation down-modulation|nmod|END_ENTITY	Leukemic and meningeal relapse of CD5 + intravascular large B-cell_lymphoma with down-modulation of CD20 after rituximab therapy .
1715005	0	CD5	20,23	CD20	25,29	CD5	CD20	921	54474	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changing pattern of CD5 + CD20 + double positive lymphocytes with ageing and cytotoxic chemotherapy .
25318949	0	CD5	0,3	CD20	75,79	CD5	CD20	921	54474	Gene	Gene	Diffuse|amod|START_ENTITY Large|nsubj|Diffuse Large|dobj|B-Cell_Lymphoma B-Cell_Lymphoma|nmod|Expression Expression|compound|END_ENTITY	CD5 - and CD23-Positive Splenic Diffuse Large B-Cell_Lymphoma with Very Low CD20 Expression .
7526015	0	CD5	71,74	CD20	65,69	CD5	CD20	921	54474	Gene	Gene	cells|nummod|START_ENTITY -RSB-|dep|cells -RSB-|compound|END_ENTITY	-LSB- Chronic cold_agglutinin_disease accompanied with an increase of CD20 + / CD5 + cells ; a case report -RSB- .
10586041	0	CD5	64,67	CD4	23,26	CD5	CD4	12507(Tax:10090)	12504(Tax:10090)	Gene	Gene	lineage|nmod|START_ENTITY lineage|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of CD4 lineage development and responses by CD5 .
10640739	0	CD5	0,3	CD4	100,103	CD5	CD4	921	920	Gene	Gene	costimulation|compound|START_ENTITY up-regulates|nsubj|costimulation up-regulates|nmod|activation activation|nmod|thymocytes thymocytes|compound|END_ENTITY	CD5 costimulation up-regulates the signaling to extracellular_signal-regulated_kinase activation in CD4 + CD8 + thymocytes and supports their differentiation to the CD4 lineage .
1382908	0	CD5	22,25	CD4	56,59	CD5	CD4	12507(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphoma|compound|START_ENTITY production|nmod|lymphoma production|acl|arising arising|nmod|mouse mouse|compound|END_ENTITY	IL-10 production in a CD5 + B cell lymphoma arising in a CD4 monoclonal antibody-treated SJL mouse .
18573278	0	CD5	0,3	CD4	67,70	CD5	CD4	12507(Tax:10090)	12504(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY plays|ccomp|T T|nsubj|role role|nmod|function function|nmod|CD25 CD25|compound|END_ENTITY	CD5 plays an inhibitory role in the suppressive function of murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T -LRB- reg -RRB- cells .
19609976	0	CD5	84,87	CD4	43,46	CD5	CD4	12507(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY absence|nmod|signaling +|nmod|absence +|nsubj|numbers numbers|nmod|CD25 CD25|compound|END_ENTITY	Increased numbers of thymic and peripheral CD4 + CD25 + Foxp3 + cells in the absence of CD5 signaling .
25199644	0	CD5	21,24	CD4	52,55	CD5	CD4	921	920	Gene	Gene	Bregs|compound|START_ENTITY Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	CD5	21,24	CD4	70,73	CD5	CD4	921	920	Gene	Gene	Bregs|compound|START_ENTITY CXCR5|dep|Bregs CXCR5|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
2783659	0	CD5	97,100	CD4	110,113	CD5	CD4	921	920	Gene	Gene	+|dep|START_ENTITY phenotype|appos|+ lymphoma|nmod|phenotype lymphoma|appos|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
8658050	0	CD5	71,74	CD4	85,88	CD5	CD4	921	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4 + CD8 + thymocytes .
9568615	0	CD5	62,65	CD4	13,16	CD5	CD4	443328(Tax:9940)	443509(Tax:9940)	Gene	Gene	cells|nummod|START_ENTITY double|nmod|cells double|nsubj|Induction Induction|nmod|+ +|compound|END_ENTITY	Induction of CD4 + CD8 + double positive T cells and increase in CD5 + B cells in efferent lymph in sheep infected with Trypanosoma evansi .
11579948	0	CD5	103,106	CD5	113,116	CD5	CD5	921	921	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Clinical characteristics of B-cell_lymphoma-associated hemophagocytic_syndrome -LRB- B-LAHS -RRB- : comparison of CD5 + with CD5 - B-LAHS .
11579948	0	CD5	113,116	CD5	103,106	CD5	CD5	921	921	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Clinical characteristics of B-cell_lymphoma-associated hemophagocytic_syndrome -LRB- B-LAHS -RRB- : comparison of CD5 + with CD5 - B-LAHS .
7515814	0	CD5	14,17	CD5	36,39	CD5	CD5	921	921	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD5 and CD38 by human CD5 - B cells : requirement for special stimuli .
7515814	0	CD5	36,39	CD5	14,17	CD5	CD5	921	921	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD5 and CD38 by human CD5 - B cells : requirement for special stimuli .
1709216	0	CD5	1,4	CD7	7,10	CD5	CD7	921	924	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	-LSB- CD5 + , CD7 + , and CD19 + non-Hodgkin 's _ lymphoma in a child -RSB- .
24617050	0	CD5	40,43	CD7	44,47	CD5	CD7	921	924	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	P-glycoprotein-1 functional activity in CD5 + CD7 + and CD20 + lymphocytes in systemic_lupus_erythematosus children : relation to disease activity , complications and steroid response .
2783659	0	CD5	97,100	CD7	89,92	CD5	CD7	921	924	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
7513945	0	CD5	49,52	CD7	44,47	CD5	CD7	921	924	Gene	Gene	CD2|compound|START_ENTITY CD2|compound|END_ENTITY	Lineage determination of CD7 + CD5 - CD2 - and CD7 + CD5 + CD2 - lymphoblasts : studies on phenotype , genotype , and gene expression of myeloperoxidase , CD3_epsilon , and CD3_delta .
10640739	0	CD5	0,3	CD8	104,107	CD5	CD8	921	925	Gene	Gene	costimulation|compound|START_ENTITY up-regulates|nsubj|costimulation up-regulates|nmod|activation activation|nmod|thymocytes thymocytes|compound|END_ENTITY	CD5 costimulation up-regulates the signaling to extracellular_signal-regulated_kinase activation in CD4 + CD8 + thymocytes and supports their differentiation to the CD4 lineage .
14568926	0	CD5	43,46	CD8	0,3	CD5	CD8	921	925	Gene	Gene	expression|nummod|START_ENTITY source|nsubj|expression surface|ccomp|source alpha|ccomp|surface alpha|nsubj|+ +|compound|END_ENTITY	CD8 + alpha beta + T cells that lack surface CD5 antigen expression are a major lymphotactin -LRB- XCL1 -RRB- source in peripheral blood lymphocytes .
20065997	0	CD5	109,112	CD8	42,45	CD5	CD8	921	925	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|responsiveness responsiveness|nmod|cells cells|compound|END_ENTITY	Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression .
24051121	0	CD5	19,22	CD8	47,50	CD5	CD8	921	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of CD5 expression on activated CD8 + T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations .
25252047	0	CD5	25,28	CD8	57,60	CD5	CD8	921	925	Gene	Gene	deficiency|nmod|START_ENTITY downregulation|nsubj|deficiency downregulation|nmod|cells cells|compound|END_ENTITY	Munc13-4 deficiency with CD5 downregulation on activated CD8 + T cells .
7586735	0	CD5	37,40	CD8	6,9	CD5	CD8	921	925	Gene	Gene	expression|nummod|START_ENTITY lacking|dobj|expression population|acl|lacking population|compound|END_ENTITY	A CD3 + CD8 + T cell population lacking CD5 antigen expression is expanded in peripheral blood of human_immunodeficiency_virus-infected patients .
8658050	0	CD5	71,74	CD8	90,93	CD5	CD8	921	925	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4 + CD8 + thymocytes .
8881750	0	CD5	140,143	CD8	33,36	CD5	CD8	921	925	Gene	Gene	CD28|nummod|START_ENTITY molecules|dep|CD28 maintenance|amod|molecules loss|nmod|maintenance Factors|dep|loss Factors|acl:relcl|influence influence|dobj|apoptosis apoptosis|compound|END_ENTITY	Factors that influence activated CD8 + T-cell apoptosis in patients with acute_herpesvirus_infections : loss of costimulatory molecules CD28 , CD5 and CD6 but relative maintenance of Bax and Bcl-X expression .
9880014	0	CD5	57,60	CD8	62,65	CD5	CD8	921	925	Gene	Gene	+|compound|START_ENTITY equid_herpesvirus-1|nmod|+ reactivation|nmod|equid_herpesvirus-1 leukocytes|nmod|reactivation leukocytes|nsubj|+ +|compound|END_ENTITY	In vitro reactivation of latent equid_herpesvirus-1 from CD5 + / CD8 + leukocytes indirectly by IL-2 or chorionic gonadotrophin .
25199644	0	CD5	21,24	Foxp3	56,61	CD5	Foxp3	921	50943	Gene	Gene	Bregs|compound|START_ENTITY Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
26884645	0	CD5	60,63	Granzyme_B	35,45	CD5	Granzyme B	921	3002	Gene	Gene	B|compound|START_ENTITY END_ENTITY|nmod|B	Increased IL-21 Expression Induces Granzyme_B in Peripheral CD5 -LRB- + -RRB- B Cells as a Potential Counter-Regulatory Effect in Primary Sj gren 's Syndrome .
12393419	0	CD5	6,9	IL-10	68,73	CD5	IL-10	921	3586	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|stimulation stimulation|nmod|production production|compound|END_ENTITY	Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production .
1382908	0	CD5	22,25	IL-10	0,5	CD5	IL-10	12507(Tax:10090)	16153(Tax:10090)	Gene	Gene	lymphoma|compound|START_ENTITY production|nmod|lymphoma production|compound|END_ENTITY	IL-10 production in a CD5 + B cell lymphoma arising in a CD4 monoclonal antibody-treated SJL mouse .
19758163	0	CD5	39,42	IL-10	0,5	CD5	IL-10	921	3586	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing production|nmod|cells production|compound|END_ENTITY	IL-10 production by B cells expressing CD5 with the alternative exon 1B .
21398617	0	CD5	0,3	IL-10	13,18	CD5	IL-10	921	3586	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	CD5 promotes IL-10 production in chronic_lymphocytic_leukemia B cells through STAT3 and NFAT2 activation .
21786452	0	CD5	44,47	IL-10	0,5	CD5	IL-10	921	3586	Gene	Gene	produced|nmod|START_ENTITY produced|nsubjpass|END_ENTITY	IL-10 is predominantly produced by CD19 -LRB- low -RRB- CD5 -LRB- + -RRB- regulatory B cell subpopulation : characterisation of CD19 -LRB- high -RRB- and CD19 -LRB- low -RRB- subpopulations of CD5 -LRB- + -RRB- B cells .
26964093	0	CD5	61,64	IL-10	0,5	CD5	IL-10	12507(Tax:10090)	16153(Tax:10090)	Gene	Gene	B|compound|START_ENTITY Expansion|nmod|B Sustaining|dobj|Expansion Critical|advcl|Sustaining Critical|nsubj|Production Production|compound|END_ENTITY	IL-10 Production Is Critical for Sustaining the Expansion of CD5 + B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice .
9184920	0	CD5	49,52	IL-10	40,45	CD5	IL-12	12507(Tax:10090)	64546(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	IL-12 directly stimulates expression of IL-10 by CD5 + B cells and IL-6 by both CD5 + and CD5 - B cells : possible involvement in age-associated cytokine dysregulation .
1379131	0	CD5	46,49	IL-4	0,4	CD5	IL-4	921	3565	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	IL-4 down-regulates the surface expression of CD5 on B cells and inhibits spontaneous immunoglobulin and IgM-rheumatoid factor production in patients with rheumatoid_arthritis .
19380809	0	CD5	15,18	IL-6	0,4	CD5	IL-6	921	3569	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation .
9184920	0	CD5	79,82	IL-6	66,70	CD5	IL-6	12507(Tax:10090)	16193(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	IL-12 directly stimulates expression of IL-10 by CD5 + B cells and IL-6 by both CD5 + and CD5 - B cells : possible involvement in age-associated cytokine dysregulation .
7525081	0	CD5	42,45	Ig	25,27	CD5	Ig	12507(Tax:10090)	17329(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Signals through membrane Ig of peritoneal CD5 B cells to suppress LPS-induced Ig secretion .
7525081	0	CD5	42,45	Ig	78,80	CD5	Ig	12507(Tax:10090)	17329(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Ig|nmod|cells Signals|nmod|Ig Signals|acl|suppress suppress|dobj|secretion secretion|compound|END_ENTITY	Signals through membrane Ig of peritoneal CD5 B cells to suppress LPS-induced Ig secretion .
9720722	0	CD5	79,82	Interleukin-10	0,14	CD5	Interleukin-10	921	3586	Gene	Gene	B-cells|compound|START_ENTITY proliferation|nmod|B-cells inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5 + B-cells .
3259609	0	CD5	56,59	Leu-1	61,66	CD5	Leu-1	921	921	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Human monoclonal rheumatoid factor-like antibodies from CD5 -LRB- Leu-1 -RRB- + B cells are polyreactive .
3096877	0	CD5	58,61	Leu1	52,56	CD5	Leu1	921	921	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Phenotypic and functional characterization of human Leu1 -LRB- CD5 -RRB- B cells .
16481048	0	CD5	0,3	Mac-1	5,10	CD5	Mac-1	12507(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	CD5 + / Mac-1 - peritoneal B cells : a novel B cell subset that exhibits characteristics of B-1 cells .
2456938	0	CD5	38,41	Mac-1	17,22	CD5	Mac-1	921	3689	Gene	Gene	cells|compound|START_ENTITY Co-expression|nmod|cells Co-expression|nmod|END_ENTITY	Co-expression of Mac-1 and p150 ,95 on CD5 + B cells .
15843554	0	CD5	103,106	RAGs	14,18	CD5	RAGs	921	1946	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5 .
21701493	0	CD5	34,37	SHP-1	13,18	CD5	SHP-1	921	5777	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell_chronic_lymphocytic_leukemia cells .
22718263	0	CD5	108,111	TGF-b	122,127	CD5	TGF-b	12507(Tax:10090)	21803(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic_airway_disease are CD5 + , express TGF-b , and co-localize with CD4 + Foxp3 + T cells .
7537538	0	CD5	15,18	Th1	22,25	CD5	Th1	921	51497	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CD5 in Th1 and Th2 contact-mediated rescue of anti-mu and ionomycin induced growth inhibition in a B_cell_lymphoma .
7507474	0	CD5	114,117	bcl-2	94,99	CD5	bcl-2	12507(Tax:10090)	12043(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	H-2z homozygous New Zealand mice as a model for B-cell_chronic_lymphocytic_leukemia : elevated bcl-2 expression in CD5 B cells at premalignant and malignant stages .
8616092	0	CD5	10,13	bcl-2	95,100	CD5	bcl-2	921	596	Gene	Gene	B-cell|compound|START_ENTITY apoptosis|nsubj|B-cell apoptosis|dobj|co-incidence co-incidence|nmod|death death|nmod|expression expression|amod|END_ENTITY	Leukaemic CD5 + B-cell apoptosis : co-incidence of cell death and DNA fragmentation with reduced bcl-2 expression .
9407720	0	CD5	63,66	bcl-2	42,47	CD5	bcl-2	921	596	Gene	Gene	+|compound|START_ENTITY flow|nmod|+ flow|dobj|evaluation evaluation|nmod|oncoprotein oncoprotein|amod|END_ENTITY	Comparative flow cytometric evaluation of bcl-2 oncoprotein in CD5 + and CD5 - B-cell lymphoid_chronic_leukemias .
9834084	0	CD5	6,9	casein_kinase_II	86,102	CD5	casein kinase II	921	1457	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein_kinase_II .
10354374	0	CD5	95,98	interleukin-10	17,31	CD5	interleukin-10	921	3586	Gene	Gene	B|compound|START_ENTITY B|amod|END_ENTITY	Possible role of interleukin-10 in autoantibody production and in the fate of human cord blood CD5 + B lymphocytes .
12765298	0	CD5	108,111	interleukin-10	83,97	CD5	interleukin-10	921	3586	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells END_ENTITY|acl|producing	Assessment of Be1 and Be2 cells in systemic_lupus_erythematosus indicates elevated interleukin-10 producing CD5 + B cells .
23363797	0	CD5	38,41	interleukin-10	10,24	CD5	interleukin-10	921	3586	Gene	Gene	B|compound|START_ENTITY secretion|nmod|B cells|amod|secretion cells|amod|END_ENTITY	-LSB- Impaired interleukin-10 secretion by CD5 -LRB- + -RRB- B cells in patients with primary immune_thrombocytopenia -RSB- .
2467815	0	CD5	61,64	interleukin_4	6,19	CD5	interleukin 4	921	3565	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Human interleukin_4 down-regulates the surface expression of CD5 on normal and leukemic B cells .
16918536	0	CD52	0,4	CD4	22,25	CD52	CD4	1043	920	Gene	Gene	ligation|compound|START_ENTITY induces|nsubj|ligation induces|dobj|END_ENTITY	CD52 ligation induces CD4 and CD8 down modulation in vivo and in vitro .
8851300	1	CD52	105,109	CD4	100,103	CD52	CD4	1043	920	Gene	Gene	CD3|dep|START_ENTITY CD3|dep|END_ENTITY	Therapy with monoclonal antibodies to T-cell antigens -LRB- CD3 , CD4 , CD52 -RRB- -RSB- .
9291477	0	CD52	44,48	HE5	50,53	CD52	HE5	1043	1043	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the human epididymal protein CD52 -LRB- HE5 -RRB- with epididymal spermatozoa from men and cynomolgus_monkeys .
7541368	0	CD54	32,36	CD34	51,55	CD54	CD34	3383	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Modulation of adhesion molecule CD54 expression on CD34 + hematopoietic progenitors .
1373957	0	CD54	83,87	CD38	68,72	CD54	CD38	3383	952	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Multiparameter analyses of normal and malignant human plasma cells : CD38 + + , CD56 + , CD54 + , cIg + is the common phenotype of myeloma cells .
16113601	0	CD54	99,103	CD80	105,109	CD54	CD80	15894(Tax:10090)	12519(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54 , CD80 , CD86 , and CD137L generate antitumor immunity in mice .
7495758	0	CD54	124,128	CD80	67,71	CD54	CD80	3383	941	Gene	Gene	expression|compound|START_ENTITY dependent|nmod|expression dependent|nmod|B7 B7|appos|END_ENTITY	The primary alloresponse of human CD4 + T cells is dependent on B7 -LRB- CD80 -RRB- , augmented by CD58 , but relatively uninfluenced by CD54 expression .
16113601	0	CD54	99,103	CD86	111,115	CD54	CD86	15894(Tax:10090)	12524(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54 , CD80 , CD86 , and CD137L generate antitumor immunity in mice .
22346780	0	CD54	56,60	CD86	26,30	CD54	CD86	3383	942	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Cross-linking of CD80 and CD86 Diminishes Expression of CD54 on EBV-transformed B Cells through Inactivation of RhoA and Ras .
10617927	0	CD54	16,20	ICAM-1	8,14	CD54	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of ICAM-1 -LRB- CD54 -RRB- in the development of murine cerebral_malaria .
11243408	0	CD54	53,57	ICAM-1	45,51	CD54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human_parainfluenza_virus_type_3 upregulates ICAM-1 -LRB- CD54 -RRB- expression in a cytokine-independent manner .
11565953	0	CD54	8,12	ICAM-1	0,6	CD54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	ICAM-1 -LRB- CD54 -RRB- expression on T lymphocytes and natural killer cells from umbilical cord blood : regulation with interleukin-12 and interleukin-15 .
12660163	0	CD54	22,26	ICAM-1	14,20	CD54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p53 activates ICAM-1 -LRB- CD54 -RRB- expression in an NF-kappaB-independent manner .
14755544	0	CD54	130,134	ICAM-1	136,142	CD54	ICAM-1	3383	3383	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Recruitment and proliferation of T lymphocytes is supported by IFNgamma - and TNFalpha-activated human osteoblasts : Involvement of CD54 -LRB- ICAM-1 -RRB- and CD106 -LRB- VCAM-1 -RRB- adhesion molecules and CXCR3 chemokine receptor .
1671356	0	CD54	38,42	ICAM-1	30,36	CD54	ICAM-1	3383	3383	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the adhesion molecule ICAM-1 -LRB- CD54 -RRB- in staphylococcal enterotoxin-mediated cytotoxicity .
1973649	0	CD54	40,44	ICAM-1	32,38	CD54	ICAM-1	3383	3383	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of human thyroid cell ICAM-1 -LRB- CD54 -RRB- antigen expression and ICAM-1-mediated lymphocyte binding .
7516927	0	CD54	22,26	ICAM-1	14,20	CD54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Regulation of ICAM-1 -LRB- CD54 -RRB- expression in human breast_cancer cell lines by interleukin 6 and fibroblast-derived factors .
7531732	0	CD54	64,68	ICAM-1	53,59	CD54	ICAM-1	3383	3383	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Cetirizine reduces inflammatory cell recruitment and ICAM-1 -LRB- or CD54 -RRB- expression on conjunctival epithelium in both early - and late-phase reactions after allergen-specific challenge .
7538157	0	CD54	40,44	ICAM-1	32,38	CD54	ICAM-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of adhesion molecule ICAM-1 -LRB- CD54 -RRB- in thyroid papillary_adenocarcinoma .
7747416	0	CD54	65,69	ICAM-1	57,63	CD54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Early induction of interferon-independent virus-specific ICAM-1 -LRB- CD54 -RRB- expression by flavivirus in quiescent but not proliferating fibroblasts -- implications for virus-host interactions .
7912996	0	CD54	8,12	ICAM-1	0,6	CD54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	ICAM-1 -LRB- CD54 -RRB- expression on B lymphocytes is associated with their costimulatory function and can be increased by coactivation with IL-1 and IL-7 .
8105044	0	CD54	27,31	ICAM-1	33,39	CD54	ICAM-1	3383	3383	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated levels of soluble CD54 -LRB- ICAM-1 -RRB- in human_immunodeficiency_virus_infection .
9766633	0	CD54	88,92	ICAM-1	80,86	CD54	ICAM-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-18 / interferon-gamma-inducing_factor , a novel cytokine , up-regulates ICAM-1 -LRB- CD54 -RRB- expression in KG-1 cells .
12650676	0	CD54	106,110	THP-1	134,139	CD54	THP-1	3383	2736	Gene	Gene	molecules|appos|START_ENTITY expression|nmod|molecules using|dobj|expression using|nmod|line line|amod|END_ENTITY	Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules , CD54 and CD86 , on the naive THP-1 cell line .
17119987	0	CD54	84,88	THP-1	120,125	CD54	THP-1	3383	2736	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Prediction of preservative sensitization potential using surface marker CD86 and/or CD54 expression on human cell line , THP-1 .
21826143	0	CD54	30,34	THP-1	38,43	CD54	THP-1	3383	2736	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test .
15753842	0	CD54	11,15	intercellular_adhesion_molecule-1	17,50	CD54	intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for CD54 -LRB- intercellular_adhesion_molecule-1 -RRB- in leukocyte recruitment to the lung during the development of experimental idiopathic_pneumonia_syndrome .
1671649	0	CD54	49,53	intercellular_adhesion_molecule-1	14,47	CD54	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- CD54 -RRB- on hematopoietic progenitors .
16818763	0	CD55	18,22	CD4	32,35	CD55	CD4	1604	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Costimulation via CD55 on human CD4 + T cells mediated by CD97 .
16563273	0	CD55	49,53	CD59	55,59	CD59	CD59	966	966	Gene	Gene	expression|nmod|START_ENTITY -LSB-|nmod|expression -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The effect of atorvastatin on the expression of CD55 , CD59 in patients with hyperlipidemia -RSB- .
10834315	0	CD55	70,74	DAF	65,68	CD55	DAF	1604	1604	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Porcine MCP gene promoter directs high level expression of human DAF -LRB- CD55 -RRB- in transgenic_mice .
11840345	0	CD55	21,25	DAF	16,19	CD55	DAF	1604	1604	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of DAF -LRB- CD55 -RRB- on orbital fibroblasts by cytokines .
11328604	0	CD55	18,22	dDAF	12,16	CD55	dDAF	13136(Tax:10090)	34826(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A synthetic dDAF _ -LRB- CD55 -RRB- gene based on optimal codon usage for transgenic animals .
14530374	0	CD55	55,59	decay-accelerating_factor	28,53	CD55	decay-accelerating factor	1604	1604	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Antiadhesive role of apical decay-accelerating_factor -LRB- CD55 -RRB- in human neutrophil transmigration across mucosal_epithelia .
17167176	0	CD55	56,60	decay-accelerating_factor	29,54	CD55	decay-accelerating factor	1604	1604	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression and action of decay-accelerating_factor -LRB- CD55 -RRB- in human malignancies and cancer therapy .
7687624	0	CD55	41,45	decay-accelerating_factor	14,39	CD55	decay-accelerating factor	1604	1604	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of decay-accelerating_factor -LRB- CD55 -RRB- of the complement system on human spermatozoa .
9565358	0	CD55	54,58	decay-accelerating_factor	27,52	CD55	decay-accelerating factor	1604	1604	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Up-regulated expression of decay-accelerating_factor -LRB- CD55 -RRB- confers increased complement resistance to sprouting neural cells .
24703255	0	CD55	83,87	decay_accelerating_factor	56,81	CD55	decay accelerating factor	13136(Tax:10090)	13136(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The effects of prednisone and steroid-sparing agents on decay_accelerating_factor -LRB- CD55 -RRB- expression : implications in myasthenia_gravis .
10222066	0	CD56	92,96	CCR7	0,4	CD56	CCR7	4684	1236	Gene	Gene	CD16|compound|START_ENTITY cells|dep|CD16 chemoattractants|nmod|cells chemoattractants|nsubj|ligands ligands|nummod|END_ENTITY	CCR7 ligands , SLC/6Ckine/Exodus2 / TCA4 and CKbeta-11 / MIP-3beta / ELC , are chemoattractants for CD56 -LRB- + -RRB- CD16 -LRB- - -RRB- NK cells and late stage lymphoid progenitors .
23028633	0	CD56	27,31	CCR7	8,12	CD56	CCR7	4684	1236	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
23028633	0	CD56	70,74	CCR7	8,12	CD56	CCR7	4684	1236	Gene	Gene	phenotype|compound|START_ENTITY associated|nmod|phenotype NK|ccomp|associated NK|nsubj|Loss Loss|nmod|expression expression|nummod|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
21469096	0	CD56	16,20	CD117	0,5	CD56	CD117	4684	3815	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD117 CD3 CD56 OX40Lhigh cells express IL-22 and display an LTi phenotype in human secondary lymphoid tissues .
25595995	0	CD56	28,32	CD117	20,25	CD56	CD117	4684	3815	Gene	Gene	-|compound|START_ENTITY -|dep|END_ENTITY	Intratumoral CD68 - , CD117 - , CD56 - , and CD1a-positive immune cells and the survival of Iranian patients with non-metastatic intestinal-type gastric_carcinoma .
11252817	0	CD56	49,53	CD16	59,63	CD56	CD16	4684	2214	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Proliferative and cytotoxic capabilities of CD16 + CD56 - and CD16 + / - CD56 + natural killer cells .
11252817	0	CD56	66,70	CD16	44,48	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY capabilities|dep|+ capabilities|nmod|CD56 CD56|compound|END_ENTITY	Proliferative and cytotoxic capabilities of CD16 + CD56 - and CD16 + / - CD56 + natural killer cells .
11252817	0	CD56	66,70	CD16	59,63	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY capabilities|dep|+ capabilities|nmod|CD56 CD56|dep|+ +|compound|END_ENTITY	Proliferative and cytotoxic capabilities of CD16 + CD56 - and CD16 + / - CD56 + natural killer cells .
11883210	0	CD56	92,96	CD16	86,90	CD56	CD16	4684	2214	Gene	Gene	cells|nummod|START_ENTITY cells|dep|-LSB- -LSB-|dobj|influence influence|nmod|lymphocytes lymphocytes|acl|immunization immunization|nmod|percentage percentage|nmod|+ +|compound|END_ENTITY	-LSB- The influence of paternal lymphocytes immunization on percentage of peripheral blood CD16 + / CD56 + cells in women with primary recurrent spontaneous_abortion -RSB- .
12076260	0	CD56	61,65	CD16	44,48	CD56	CD16	4684	2214	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Uncoupling activation-induced modulation of CD16 and CD69 in CD56 + cells during AIDS .
12412742	0	CD56	66,70	CD16	52,56	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY Suppression|dep|+ Suppression|nmod|immunoglobulin immunoglobulin|acl|synthesis synthesis|nmod|END_ENTITY	Suppression of in vitro immunoglobulin synthesis by CD16 -LRB- Leu11a -RRB- + CD56 -LRB- NKH1 , Leu19 -RRB- + non-T lineage NK cells ; lack of suppression of cells from immunodeficient patients .
1375847	0	CD56	6,10	CD16	0,4	CD56	CD16	4684	2214	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dep|cells	CD16 - CD56 + natural killer cells after bone marrow transplantation .
14505740	0	CD56	50,54	CD16	56,60	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Fraction of the peripheral blood concentration of CD56 + / CD16 - / CD3 - cells in total natural killer cells as an indication of fertility and infertility .
14616964	0	CD56	33,37	CD16	39,43	CD56	CD16	4684	2214	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	TCR Vbeta repertoire analysis in CD56 + CD16 -LRB- dim / - -RRB- T-cell large granular lymphocyte leukaemia : association with CD4 single and CD4/CD8 double positive phenotypes .
16904757	0	CD56	21,25	CD16	15,19	CD56	CD16	4684	2214	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Persistence of CD16 + / CD56 - / 2B4 + natural killer cells : a highly dysfunctional NK subset expanded in ocular myasthenia_gravis .
1692496	0	CD56	19,23	CD16	34,38	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY populations|nmod|+ populations|dep|cells cells|nummod|END_ENTITY	Two populations of CD56 -LRB- Leu-19 -RRB- + / CD16 + cells in bone marrow transplant recipients .
17878347	0	CD56	166,170	CD16	160,164	CD56	CD16	4684	2214	Gene	Gene	subset|compound|START_ENTITY subset|nummod|+ +|compound|END_ENTITY	The CD16 - CD56 -LRB- bright -RRB- NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16 + CD56 -LRB- dim -RRB- subset .
18203207	0	CD56	82,86	CD16	94,98	CD56	CD16	4684	2214	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural killer cells infiltrating human nonsmall-cell_lung_cancer are enriched in CD56 bright CD16 -LRB- - -RRB- cells and display an impaired capability to kill tumor cells .
1828937	0	CD56	103,107	CD16	97,101	CD56	CD16	4684	2214	Gene	Gene	CD57|appos|START_ENTITY CD57|appos|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
20543659	0	CD56	80,84	CD16	86,90	CD56	CD16	4684	2214	Gene	Gene	expansion|nmod|START_ENTITY contribute|nmod|expansion contribute|parataxis|+ +|nsubj|END_ENTITY	Phenotypically and functionally distinct subsets contribute to the expansion of CD56 - / CD16 + natural killer cells in HIV_infection .
20553754	0	CD56	51,55	CD16	0,4	CD56	CD16	4684	2214	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|cross-linking cross-linking|compound|END_ENTITY	CD16 cross-linking induces increased expression of CD56 and production of IL-12 in peripheral NK cells .
20664990	0	CD56	32,36	CD16	27,31	CD56	CD16	4684	2214	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural killer-like T CD3 + / CD16 + CD56 + cells in chronic_lymphocytic_leukemia : intracellular cytokine expression and relationship with clinical outcome .
20734041	0	CD56	60,64	CD16	68,72	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY infiltrating|dobj|+ tumor|acl|infiltrating Identification|nmod|tumor Identification|parataxis|NK NK|nsubj|END_ENTITY	Identification and characterization of a tumor infiltrating CD56 -LRB- + -RRB- / CD16 -LRB- - -RRB- NK cell subset with specificity for pancreatic_and_prostate_cancer cell lines .
21187373	0	CD56	72,76	CD16	81,85	CD56	CD16	4684	2214	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Revisiting human natural killer cell subset function revealed cytolytic CD56 -LRB- dim -RRB- CD16 + NK cells as rapid producers of abundant IFN-gamma on activation .
21457956	0	CD56	74,78	CD16	79,83	CD56	CD16	4684	2214	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Maturation of human ovarian follicles is accompanied by a decrease in the CD56 + CD16 + natural killer cell population .
21526506	0	CD56	10,14	CD16	5,9	CD56	CD16	4684	2214	Gene	Gene	numbers|compound|START_ENTITY numbers|compound|END_ENTITY	CD3 + / CD16 + CD56 + cell numbers in peripheral blood are correlated with higher_tumor burden in patients with diffuse_large_B-cell_lymphoma .
21996223	0	CD56	38,42	CD16	33,37	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Lymphocyte subtypes CD3 + , CD19 + , CD16 + CD56 + , CD4 + , CD8 + , and CD3 + HLA-DR + in peripheral blood obtained from patients after thoracic organ transplantation .
23028633	0	CD56	27,31	CD16	79,83	CD56	CD16	4684	2214	Gene	Gene	expression|nmod|START_ENTITY Loss|nmod|expression NK|nsubj|Loss NK|ccomp|associated associated|nmod|phenotype phenotype|compound|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
23028633	0	CD56	70,74	CD16	79,83	CD56	CD16	4684	2214	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
24225017	0	CD56	17,21	CD16	30,34	CD56	CD16	4684	2214	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Mature cytotoxic CD56 -LRB- bright -RRB- / CD16 -LRB- + -RRB- natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma .
26330348	0	CD56	21,25	CD16	34,38	CD56	CD16	4684	2214	Gene	Gene	Human|dep|START_ENTITY Human|parataxis|retained retained|nsubjpass|cells cells|amod|END_ENTITY	Human liver-resident CD56 -LRB- bright -RRB- / CD16 -LRB- neg -RRB- NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways .
27027597	0	CD56	0,4	CD16	36,40	CD56	CD16	4684	2214	Gene	Gene	CD16|compound|START_ENTITY END_ENTITY|nsubj|CD16	CD56 -LRB- dim -RRB- CD16 -LRB- high -RRB- and CD56 -LRB- bright -RRB- CD16 -LRB- - -RRB- cell percentages associated with maximum knee extensor strength and incidence of death in elderly .
7517211	0	CD56	16,20	CD16	23,27	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY -|appos|+ -|appos|END_ENTITY	HLA-DR - , CD33 + , CD56 + , CD16 - myeloid/natural killer cell acute_leukemia : a previously unrecognized form of acute_leukemia potentially misdiagnosed as French-American-British acute_myeloid_leukemia-M3 .
7552495	0	CD56	104,108	CD16	99,103	CD56	CD16	4684	2214	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Natural killer cell immunodeficiency in HIV_disease is manifest by profoundly decreased numbers of CD16 + CD56 + cells and expansion of a population of CD16dimCD56 - cells with low lytic activity .
7587727	0	CD56	45,49	CD16	39,43	CD56	CD16	4684	2214	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	Evidence of a selective depletion of a CD16 + CD56 + CD8 + natural killer cell subset during HIV_infection .
7691868	0	CD56	43,47	CD16	57,61	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY +|appos|CD3 CD3|nummod|END_ENTITY	Distribution of cell adhesion molecules on CD56 + + , CD3 - , CD16 - large granular lymphocytes and endothelial cells in first-trimester human decidua .
8526995	0	CD56	34,38	CD16	40,44	CD56	CD16	4684	2214	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Up-regulated expression of CD56 + , CD56 + / CD16 + , and CD19 + cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses .
8920872	0	CD56	40,44	CD16	46,50	CD56	CD16	4684	2214	Gene	Gene	+|dep|START_ENTITY +|dep|END_ENTITY	Definition of a natural killer NKR-P1A + / CD56 - / CD16 - functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12 .
8993118	0	CD56	13,17	CD16	6,10	CD56	CD16	4684	2214	Gene	Gene	cells|nummod|START_ENTITY +|appos|cells +|appos|+ +|compound|END_ENTITY	CD3 + , CD16 + , CD56 + cells : a novel subset of T lymphocytes from patients with Balkanic_nephropathy .
9009088	0	CD56	68,72	CD16	61,65	CD57	CD56	27087	4684	Gene	Gene	+|compound|START_ENTITY growth|appos|+ growth|amod|+ +|dep|END_ENTITY	Autocrine IL-2-dependent growth of a newly established CD3 + , CD16 - , CD56 + , CD57 + , J -LRB- H -RRB- - , TCRbeta - , TCRgamma - _ leukemia cell line -LRB- NOI-90 -RRB- .
11174380	0	CD56	10,14	CD2	0,3	CD56	CD2	4684	914	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	CD2 - CD4 + CD56 + hematodermic/hematolymphoid _ malignancy .
1371947	0	CD56	113,117	CD2	34,37	CD56	CD2	4684	914	Gene	Gene	molecules|compound|START_ENTITY cells|nmod|molecules endothelial|dobj|cells functional|xcomp|endothelial functional|nsubj|thymocytes thymocytes|acl|lacking lacking|dobj|antigens antigens|compound|END_ENTITY	Cultured human thymocytes lacking CD2 and CD11a/CD18 antigens are functional and adhere to endothelial cells via CD56 or CDw49d molecules .
22481022	0	CD56	24,28	CD2	30,33	CD56	CD2	4684	914	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	Detection of CD34 , TdT , CD56 , CD2 , CD4 , and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically_normal_acute_myeloid_leukemia .
7543014	0	CD56	35,39	CD2	23,26	CD56	CD2	4684	914	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|Aggressive Aggressive|xcomp|pleomorphic pleomorphic|dep|END_ENTITY	Aggressive pleomorphic CD2 + , CD3 - , CD56 + lymphoma with t -LRB- 5 ; 9 -RRB- -LRB- q31 ; q34 -RRB- abnormality .
9790118	0	CD56	12,16	CD2	0,3	CD56	CD2	4684	914	Gene	Gene	+|compound|START_ENTITY +|appos|+ -|appos|+ -|compound|END_ENTITY	CD2 - , CD4 + , CD56 + agranular natural killer cell lymphoma of the skin .
9858215	0	CD56	119,123	CD2	93,96	CD56	CD2	4684	914	Gene	Gene	phenotype|compound|START_ENTITY lymphoma|appos|phenotype lymphoma|nmod|END_ENTITY	Establishment of an IL-2-dependent cell line derived from ` nasal-type ' NK/T-cell _ lymphoma of CD2 + , sCD3 - , CD3epsilon + , CD56 + phenotype and associated with the Epstein-Barr_virus .
11756778	0	CD56	55,59	CD30	48,52	CD56	CD30	4684	943	Gene	Gene	+|compound|START_ENTITY Epstein-Barr_virus-associated|appos|+ Epstein-Barr_virus-associated|appos|+ +|compound|END_ENTITY	Aggressive Epstein-Barr_virus-associated , CD8 + , CD30 + , CD56 + , surface CD3 - , natural killer -LRB- NK -RRB- - like cytotoxic T-cell_lymphoma .
10391105	2	CD56	385,389	CD33	376,380	CD33	CD13	945	290	Gene	Gene	+|appos|START_ENTITY +|appos|END_ENTITY	We describe the morphological , cytochemical , immunologic , and cytogenetic features of two patients with AML with maturation -LRB- FAB_M2 -RRB- and the phenotype MPO + , CD13 _ -LRB- - -RRB- , CD33 -LRB- - -RRB- , CD56 -LRB- + -RRB- .
1373957	0	CD56	76,80	CD38	68,72	CD56	CD38	4684	952	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Multiparameter analyses of normal and malignant human plasma cells : CD38 + + , CD56 + , CD54 + , cIg + is the common phenotype of myeloma cells .
7545096	0	CD56	239,243	CD38	205,209	CD56	CD38	4684	952	Gene	Gene	+|compound|START_ENTITY molecules|appos|+ molecules|appos|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
10651077	0	CD56	28,32	CD4	24,27	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased CD4 + CD16 + and CD4 + CD56 + T cell subsets in Beh et 's disease .
11167804	0	CD56	38,42	CD4	31,34	CD56	CD4	4684	920	Gene	Gene	granular|amod|START_ENTITY lymphocytes|nsubj|granular expansion|parataxis|lymphocytes expansion|nmod|CD3 CD3|dep|END_ENTITY	Polyclonal expansion of CD3 -LRB- + -RRB- / CD4 -LRB- + -RRB- / CD56 -LRB- + -RRB- large granular lymphocytes and autoimmunity associated with dysregulation of Fas/FasL apoptotic pathway .
11174380	0	CD56	10,14	CD4	5,8	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD2 - CD4 + CD56 + hematodermic/hematolymphoid _ malignancy .
11401089	0	CD56	14,18	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	natural_killer_leukemia|compound|START_ENTITY natural_killer_leukemia|compound|END_ENTITY	Agranular CD4 + CD56 + blastic natural_killer_leukemia / lymphoma .
11488062	0	CD56	0,4	CD4	6,9	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|parataxis|morphologically morphologically|nsubj|lymphomas lymphomas|compound|END_ENTITY	CD56 + / CD4 + lymphomas and leukemias are morphologically , immunophenotypically , cytogenetically , and clinically diverse .
11757730	0	CD56	20,24	CD4	15,18	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY CD8|nsubj|+ Association|parataxis|CD8 Association|nmod|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12131152	0	CD56	104,108	CD4	11,14	CD56	CD4	4684	920	Gene	Gene	cells|nummod|START_ENTITY population|nmod|cells originates|nmod|population originates|nsubj|neoplasm neoplasm|compound|END_ENTITY	` Agranular CD4 + CD56 + hematodermic neoplasm ' -LRB- blastic_NK-cell_lymphoma -RRB- originates from a population of CD56 + precursor cells related to plasmacytoid monocytes .
12131152	0	CD56	16,20	CD4	11,14	CD56	CD4	4684	920	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	` Agranular CD4 + CD56 + hematodermic neoplasm ' -LRB- blastic_NK-cell_lymphoma -RRB- originates from a population of CD56 + precursor cells related to plasmacytoid monocytes .
12389632	0	CD56	15,19	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY cutaneous|nsubj|+ +|parataxis|cutaneous +|compound|END_ENTITY	Agranular CD4 + / CD56 + cutaneous neoplasm .
12483012	0	CD56	4,8	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	CD68|compound|START_ENTITY CD68|compound|END_ENTITY	CD4 + CD56 + CD68 + hematopoietic_tumor of probable plasmacytoid monocyte derivation with weak expression of cytoplasmic CD3 .
12591970	0	CD56	13,17	CD4	7,10	CD56	CD4	4684	920	Gene	Gene	infiltrate|compound|START_ENTITY +|appos|infiltrate +|compound|END_ENTITY	Florid CD4 + , CD56 + T-cell infiltrate associated with Herpes_simplex_infection simulating nasal NK - / T-cell_lymphoma .
12688346	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	neoplasia|compound|START_ENTITY neoplasia|compound|END_ENTITY	CD4 + CD56 + neoplasia : clinical and biological features with emphasis on cytotoxic drug-induced apoptosis and expression of sialyl Lewis X. CD4 + CD56 + neoplasia is a rare malignancy of unclarified origin .
12695132	0	CD56	29,33	CD4	23,26	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Skin manifestations in CD4 + , CD56 + malignancies .
12876674	0	CD56	89,93	CD4	85,88	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Plasmacytoid dendritic cells : from the plasmacytoid T-cell to type 2 dendritic cells CD4 + CD56 + malignancies .
12935983	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	malignancies|compound|START_ENTITY malignancies|compound|END_ENTITY	CD4 + CD56 + lineage negative malignancies : a new entity developed from malignant early plasmacytoid dendritic cells .
13130309	0	CD56	12,16	CD4	8,11	CD56	CD4	4684	920	Gene	Gene	malignancy|compound|START_ENTITY malignancy|compound|END_ENTITY	What is CD4 + CD56 + malignancy and how should it be treated ?
14616964	0	CD56	33,37	CD4	112,115	CD56	CD4	4684	920	Gene	Gene	T-cell|compound|START_ENTITY analysis|nmod|T-cell analysis|dep|association association|nmod|phenotypes phenotypes|nummod|END_ENTITY	TCR Vbeta repertoire analysis in CD56 + CD16 -LRB- dim / - -RRB- T-cell large granular lymphocyte leukaemia : association with CD4 single and CD4/CD8 double positive phenotypes .
15048964	0	CD56	78,82	CD4	73,76	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Fine-needle aspiration cytology of blastic natural killer-cell lymphoma -LRB- CD4 + CD56 + hematodermic neoplasm -RRB- .
15107748	0	CD56	36,40	CD4	31,34	CD56	CD4	4684	920	Gene	Gene	leukemia|compound|START_ENTITY leukemia|compound|END_ENTITY	-LSB- Primary cutaneous non T non B CD4 + CD56 + leukemia -LRB- 2 cases -RRB- : an original anatomoclinical syndrome -RSB- .
15358570	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	blastic_tumor_of_the_skin|compound|START_ENTITY blastic_tumor_of_the_skin|compound|END_ENTITY	CD4 + CD56 + blastic_tumor_of_the_skin : cytogenetic observations and further evidence of an origin from plasmocytoid dendritic cells .
15602384	0	CD56	16,20	CD4	11,14	CD56	CD4	4684	920	Gene	Gene	CD123|compound|START_ENTITY CD123|compound|END_ENTITY	-LSB- Agranular CD4 + CD56 + CD123 + hematodermic neoplasm -LRB- blastic_NK-cell_lymphoma -RRB- revealed by cutaneous localization : 2 cases -RSB- .
15660891	0	CD56	78,82	CD4	73,76	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutaneous_tumors as the initial presentation of non-T , non-B , nonmyeloid CD4 + CD56 + hematolymphoid malignancy in an adolescent boy .
15692441	0	CD56	16,20	CD4	11,14	CD56	CD4	4684	920	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	-LSB- Agranular CD4 + CD56 + hematodermic neoplasm : a new case report -RSB- .
15832009	0	CD56	4,8	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD56 + lineage negative hematopoietic_neoplasm : so called blastic NK cell lymphoma .
16153467	0	CD56	4,8	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD56 + hematodermic_neoplasms bear a plasmacytoid dendritic cell phenotype .
16160468	0	CD56	7,11	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	malignancies|amod|START_ENTITY tumors|nsubj|malignancies tumors|nsubj|END_ENTITY	CD4 -LRB- + -RRB- CD56 -LRB- + -RRB- lineage-negative malignancies are rare tumors of plasmacytoid dendritic cells .
16161251	0	CD56	16,20	CD4	11,14	CD56	CD4	4684	920	Gene	Gene	neoplasm|compound|START_ENTITY -RSB-|nsubj|neoplasm +|parataxis|-RSB- +|compound|END_ENTITY	-LSB- Agranular CD4 + / CD56 + haematodermic neoplasm -LRB- Precursor haematologic neoplasm -RRB- -RSB- .
16434387	0	CD56	23,27	CD4	18,21	CD56	CD4	4684	920	Gene	Gene	hematodermic_neoplasm|compound|START_ENTITY hematodermic_neoplasm|compound|END_ENTITY	Primary cutaneous CD4 + / CD56 + hematodermic_neoplasm -LRB- blastic_NK-cell_lymphoma -RRB- : a report of five cases .
16682521	0	CD56	57,61	CD4	53,56	CD56	CD4	4684	920	Gene	Gene	leukemia|compound|START_ENTITY leukemia|compound|END_ENTITY	Blastic natural killer -LRB- NK -RRB- cell leukemia -LRB- agranular CD4 + CD56 + leukemia -RRB- .
16987271	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY haematodermic|dep|+ neoplasm|dep|haematodermic neoplasm|compound|END_ENTITY	CD4 + / CD56 + haematodermic neoplasm : a preculsor haematological neoplasm that frequently first presents in the skin .
16998465	0	CD56	105,109	CD4	100,103	CD56	CD4	4684	920	Gene	Gene	hematodermic_neoplasms|compound|START_ENTITY hematodermic_neoplasms|compound|END_ENTITY	Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4 + CD56 + hematodermic_neoplasms .
17194654	0	CD56	15,19	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Childhood CD4 + / CD56 + hematodermic neoplasm : case report and review of the literature .
17227117	0	CD56	15,19	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY hematodermic_neoplasm|nsubj|+ +|parataxis|hematodermic_neoplasm +|compound|END_ENTITY	Agranular CD4 + / CD56 + hematodermic_neoplasm : a distinct entity described in the recent World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous_lymphomas .
17284963	1	CD56	93,97	CD4	89,92	CD56	CD4	4684	920	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	We report a case of a 75-year-old man with a cutaneous CD4 + CD56 + hematodermic neoplasm .
17709319	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	CD4 + / CD56 + hematodermic neoplasm -LRB- `` blastic natural killer cell lymphoma '' -RRB- : neoplastic cells express the immature dendritic cell marker BDCA-2 and produce interferon .
17984695	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	CD4 + / CD56 + hematodermic neoplasm : blastic NK cell lymphoma in a 6-year-old child : report of a case and review of literature .
18005171	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	CD4 + / CD56 + hematodermic_neoplasm : report of a rare variant with a T-cell receptor gene rearrangement .
18091395	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY originated|nsubj|+ +|parataxis|originated +|compound|END_ENTITY	CD4 + / CD56 + hematodermic neoplasm : presentation of 2 cases and review of the concept of an uncommon tumor originated in plasmacytoid dendritic cells expressing CD123 -LRB- IL-3 receptor alpha -RRB- .
18280345	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD56 + hematodermic/plasmacytoid dendritic_cell_tumor with response to pralatrexate .
1828937	0	CD56	103,107	CD4	40,43	CD56	CD4	4684	920	Gene	Gene	CD57|appos|START_ENTITY lack|dobj|CD57 cells|acl:relcl|lack cells|nmod|skin_lesions skin_lesions|nmod|mycosis_fungoides mycosis_fungoides|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18490770	0	CD56	25,29	CD4	21,24	CD56	CD4	4684	920	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Preferential in situ CD4 + CD56 + T cell activation and expansion within human glioblastoma .
18494823	0	CD56	29,33	CD4	24,27	CD56	CD4	4684	920	Gene	Gene	hematodermic_neoplasm|compound|START_ENTITY variant|dep|hematodermic_neoplasm variant|nmod|+ +|compound|END_ENTITY	CD4-negative variant of CD4 + / CD56 + hematodermic_neoplasm : description of three cases .
18499965	0	CD56	19,23	CD4	14,17	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Hematodermic CD4 + CD56 + neoplasm in childhood -RSB- .
19094843	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	Hematodermic_neoplasm|compound|START_ENTITY Hematodermic_neoplasm|compound|END_ENTITY	CD4 + / CD56 + Hematodermic_neoplasm -LRB- plasmacytoid dendritic cell tumor -RRB- .
19155730	0	CD56	6,10	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	mycosis_fungoides|nummod|START_ENTITY +|appos|mycosis_fungoides +|compound|END_ENTITY	CD4 + , CD56 + mycosis_fungoides : case report and review of the literature .
19328310	0	CD56	72,76	CD4	62,65	CD56	CD4	4684	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	-LSB- Two cases of subcutaneous panniculitis-like T-cell_lymphoma -LRB- CD4 - CD8 + CD56 - -RRB- -RSB- .
19508475	0	CD56	18,22	CD4	14,17	CD56	CD4	4684	920	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	Haematodermic CD4 + CD56 + neoplasm : complete remission after methotrexate-asparaginase treatment .
20409415	0	CD56	15,19	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY case|dep|+ case|nmod|+ +|compound|END_ENTITY	A case of CD4 + / CD56 + hematodermic_neoplasm -LRB- plasmacytoid dendritic_cell_neoplasm -RRB- .
20541283	0	CD56	15,19	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutaneous CD4 + CD56 + hematologic_malignancies .
20548910	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY END_ENTITY|parataxis|+	CD4 - / CD56 + / CD123 + Hematodermic Neoplasm Showing Early Liver Metastasis .
21079332	0	CD56	15,19	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	neoplasm|compound|START_ENTITY +|dep|neoplasm +|compound|END_ENTITY	Cutaneous CD4 + / CD56 + hematodermic neoplasm .
21741423	0	CD56	13,17	CD4	100,103	CD56	CD4	4684	920	Gene	Gene	cells|nummod|START_ENTITY Induction|nmod|cells Induction|nmod|depletion depletion|amod|vitro vitro|dep|mechanism mechanism|nmod|T-cell T-cell|compound|END_ENTITY	Induction of CD56 + T cells after prolonged activation of T cells in vitro : a possible mechanism for CD4 + T-cell depletion in acquired immune_deficiency_syndrome patients .
22384114	0	CD56	16,20	CD4	67,70	CD56	CD4	4684	920	Gene	Gene	NK|compound|START_ENTITY Cytotoxicity|nmod|NK cells|amod|Cytotoxicity cells|nmod|cells cells|compound|END_ENTITY	Cytotoxicity of CD56 -LRB- bright -RRB- NK cells towards autologous activated CD4 + T cells is mediated through NKG2D , LFA-1 and TRAIL and dampened via CD94/NKG2A .
22838092	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	neoplasm|compound|START_ENTITY neoplasm|compound|END_ENTITY	CD4 + CD56 + hematodermic neoplasm and plasmacytoid dendritic cell tumor : case report and review of the literature .
25332519	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	Hematodermic_Neoplasm|compound|START_ENTITY Hematodermic_Neoplasm|compound|END_ENTITY	CD4 + CD56 + Hematodermic_Neoplasm Without Cutaneous Involvement .
7511637	0	CD56	58,62	CD4	54,57	CD56	CD4	4684	920	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	Selective expansion of cytotoxic T lymphocytes with a CD4 + CD56 + surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis_B_virus .
8645884	0	CD56	14,18	CD4	10,13	CD56	CD4	4684	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Homing of CD4 + CD56 + T lymphocytes into kidney allografts during tubular_necrosis or rejection .
8752917	0	CD56	26,30	CD4	22,25	CD56	CD4	4684	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel population of CD4 + CD56 + myelin-reactive T cells lyses target cells expressing CD56/neural cell adhesion molecule .
9790118	0	CD56	12,16	CD4	6,9	CD56	CD4	4684	920	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	CD2 - , CD4 + , CD56 + agranular natural killer cell lymphoma of the skin .
9989839	0	CD56	5,9	CD4	0,3	CD56	CD4	4684	920	Gene	Gene	neoplasms|compound|START_ENTITY neoplasms|compound|END_ENTITY	CD4 + CD56 + cutaneous neoplasms : a distinct hematological entity ?
12101203	0	CD56	17,21	CD45	23,27	CD56	CD45	4684	5788	Gene	Gene	+|compound|START_ENTITY Detection|nmod|+ Detection|dep|END_ENTITY	Detection of the CD56 + / CD45 - immunophenotype by flow cytometry in neuroendocrine malignancies .
23126274	0	CD56	22,26	CD45	28,32	CD56	CD45	4684	5788	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Detection of the GD2 + / CD56 + / CD45 - immunophenotype by flow cytometry in cerebrospinal fluids from a patient with retinoblastoma .
12131152	0	CD56	104,108	CD56	16,20	CD56	CD56	4684	4684	Gene	Gene	cells|nummod|START_ENTITY population|nmod|cells originates|nmod|population originates|nsubj|neoplasm neoplasm|compound|END_ENTITY	` Agranular CD4 + CD56 + hematodermic neoplasm ' -LRB- blastic_NK-cell_lymphoma -RRB- originates from a population of CD56 + precursor cells related to plasmacytoid monocytes .
12131152	0	CD56	16,20	CD56	104,108	CD56	CD56	4684	4684	Gene	Gene	neoplasm|compound|START_ENTITY originates|nsubj|neoplasm originates|nmod|population population|nmod|cells cells|nummod|END_ENTITY	` Agranular CD4 + CD56 + hematodermic neoplasm ' -LRB- blastic_NK-cell_lymphoma -RRB- originates from a population of CD56 + precursor cells related to plasmacytoid monocytes .
23028633	0	CD56	27,31	CD56	70,74	CD56	CD56	4684	4684	Gene	Gene	expression|nmod|START_ENTITY Loss|nmod|expression NK|nsubj|Loss NK|ccomp|associated associated|nmod|phenotype phenotype|compound|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
23028633	0	CD56	70,74	CD56	27,31	CD56	CD56	4684	4684	Gene	Gene	phenotype|compound|START_ENTITY associated|nmod|phenotype NK|ccomp|associated NK|nsubj|Loss Loss|nmod|expression expression|nmod|END_ENTITY	Loss of CCR7 expression on CD56 -LRB- bright -RRB- NK cells is associated with a CD56 -LRB- dim -RRB- CD16 NK cell-like phenotype and correlates with HIV viral load .
11757730	0	CD56	20,24	CD57	26,30	CD56	CD57	4684	27087	Gene	Gene	+|compound|START_ENTITY CD8|nsubj|+ CD8|dep|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12562330	0	CD56	112,116	CD57	163,167	CD56	CD57	4684	27087	Gene	Gene	CD57|compound|START_ENTITY markers|appos|CD57 characterization|nmod|markers characterization|dep|T T|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
12562330	0	CD56	133,137	CD57	139,143	CD56	CD57	4684	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
24959961	0	CD56	103,107	CD57	96,100	CD56	CD57	4684	27087	Gene	Gene	subset|compound|START_ENTITY subset|dep|loss loss|nmod|END_ENTITY	Impaired natural killer cell responses are associated with loss of the highly activated NKG2A -LRB- + -RRB- CD57 -LRB- + -RRB- CD56 -LRB- dim -RRB- subset in HIV-1_subtype_D_infection in Uganda .
25472612	0	CD56	14,18	CD57	29,33	CD56	CD57	4684	27087	Gene	Gene	KIR|compound|START_ENTITY Enrichment|nmod|KIR +|nsubj|Enrichment +|xcomp|NK NK|nsubj|+ +|compound|END_ENTITY	Enrichment of CD56 -LRB- dim -RRB- KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients .
26416461	0	CD56	0,4	CD57	9,13	CD56	CD57	4684	27087	Gene	Gene	NK|nsubj|START_ENTITY NK|nsubj|NKG2C NKG2C|compound|END_ENTITY	CD56 -LRB- dim -RRB- CD57 -LRB- + -RRB- NKG2C -LRB- + -RRB- NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT .
25595995	0	CD56	28,32	CD68	13,17	CD56	CD68	4684	968	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Intratumoral CD68 - , CD117 - , CD56 - , and CD1a-positive immune cells and the survival of Iranian patients with non-metastatic intestinal-type gastric_carcinoma .
17973783	0	CD56	8,12	CD69	0,4	CD56	CD69	4684	969	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	CD69 on CD56 + NK cells and response to chemoimmunotherapy in metastatic melanoma .
10435360	0	CD56	0,4	CD7	5,8	CD56	CD7	4684	924	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD56 + CD7 + stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement .
20111912	0	CD56	37,41	CD7	32,35	CD56	CD7	4684	924	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The clinical characteristics of CD7 + CD56 + acute_myeloid_leukemias other than M0 .
10640724	0	CD56	100,104	CD8	63,66	CD56	CD8	4684	925	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|cells cells|compound|END_ENTITY	Cutting edge : cytolytic effector function in human circulating CD8 + T cells closely correlates with CD56 surface expression .
11300476	0	CD56	14,18	CD8	55,58	CD56	CD8	4684	925	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Expression of CD56 by human_papillomavirus E7-specific CD8 + cytotoxic T lymphocytes correlates with increased intracellular perforin expression and enhanced cytotoxicity against HLA-A2-matched cervical tumor cells .
11756778	0	CD56	55,59	CD8	42,45	CD56	CD8	4684	925	Gene	Gene	+|compound|START_ENTITY Epstein-Barr_virus-associated|appos|+ Epstein-Barr_virus-associated|appos|+ +|compound|END_ENTITY	Aggressive Epstein-Barr_virus-associated , CD8 + , CD30 + , CD56 + , surface CD3 - , natural killer -LRB- NK -RRB- - like cytotoxic T-cell_lymphoma .
11757730	0	CD56	20,24	CD8	32,35	CD56	CD8	4684	925	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12562330	0	CD56	112,116	CD8	58,61	CD56	CD8	4684	925	Gene	Gene	CD57|compound|START_ENTITY markers|appos|CD57 characterization|nmod|markers characterization|nmod|subsets subsets|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
14871854	0	CD56	25,29	CD8	21,24	CD56	CD8	4684	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD8 + CD56 + and CD8 + CD56 - natural killer T cells specific for MUC1 mucin .
1828937	0	CD56	103,107	CD8	5,8	CD56	CD8	4684	925	Gene	Gene	CD57|appos|START_ENTITY lack|dobj|CD57 cells|acl:relcl|lack cells|nsubj|cells cells|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18801082	0	CD56	6,10	CD8	0,3	CD56	CD8	4684	925	Gene	Gene	T-cell_lymphoma|compound|START_ENTITY +|appos|T-cell_lymphoma +|compound|END_ENTITY	CD8 + , CD56 + -LRB- natural killer-like -RRB- T-cell_lymphoma involving the small intestine with no evidence of enteropathy : clinicopathology and molecular study of five Japanese patients .
19328310	0	CD56	72,76	CD8	67,70	CD56	CD8	4684	925	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	-LSB- Two cases of subcutaneous panniculitis-like T-cell_lymphoma -LRB- CD4 - CD8 + CD56 - -RRB- -RSB- .
22882906	0	CD56	54,58	CD8	50,53	CD56	CD8	4684	925	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|accumulation accumulation|nmod|END_ENTITY	Persistent accumulation of interferon-y-producing CD8 + CD56 + T cells in blood from patients with coronary_artery_disease .
23241021	0	CD56	47,51	CD8	42,45	CD56	CD8	4684	925	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Poikilodermatous_mycosis_fungoides with a CD8 + CD56 + immunophenotype : a case report and literature review .
23527216	0	CD56	35,39	CD8	52,55	CD56	CD8	4684	925	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Identification of cytolytic CD161 - CD56 + regulatory CD8 T cells in human peripheral blood .
24372339	0	CD56	113,117	CD8	104,107	CD56	CD8	4684	925	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	The relationship between matrix_metalloproteinases -LRB- MMP-3 , _ -8 , _ -9 -RRB- in serum and peripheral lymphocytes -LRB- CD8 -LRB- + -RRB- , CD56 -LRB- + -RRB- -RRB- in Down_syndrome children with gingivitis .
24520422	0	CD56	10,14	CD8	31,34	CD56	CD8	4684	925	Gene	Gene	TIM-3|compound|START_ENTITY Levels|nmod|TIM-3 Levels|dep|effector effector|acl:relcl|distinguish distinguish|nsubj|cells cells|compound|END_ENTITY	Levels of CD56 + TIM-3 - effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy .
25366078	0	CD56	49,53	CD8	44,47	CD56	CD8	4684	925	Gene	Gene	Phenotype|compound|START_ENTITY Phenotype|compound|END_ENTITY	Cytotoxic Variant of Mycosis Fungoides with CD8 + CD56 + Phenotype : A Case Report and Review of Literature .
25442255	0	CD56	40,44	CD8	35,38	CD56	CD8	4684	925	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Childhood_mycosis_fungoides with a CD8 + CD56 + cytotoxic immunophenotype .
26751040	0	CD56	49,53	CD8	42,45	CD56	CD8	4684	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Effect of age and latent CMV_infection on CD8 + CD56 + T cells -LRB- NKT-like -RRB- frequency and functionality .
7545096	0	CD56	239,243	CD8	126,129	CD56	CD8	4684	925	Gene	Gene	+|compound|START_ENTITY molecules|appos|+ increased|nmod|molecules increased|dobj|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7545096	0	CD56	239,243	CD8	245,248	CD56	CD8	4684	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
9811340	0	CD56	5,9	CD8	36,39	CD56	CD8	4684	925	Gene	Gene	lymphomas|amod|START_ENTITY CD5-T-cell_lymphomas|nsubj|lymphomas CD5-T-cell_lymphomas|nummod|END_ENTITY	Most CD56 + intestinal lymphomas are CD8 + CD5-T-cell_lymphomas of monomorphic small to medium size histology .
18630512	7	CD56	1307,1311	CD90	1313,1317	CD45	CD56	5788	4684	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	All the NB BM samples -LRB- 15/15 -RRB- showed the CD45 - CD56 + CD90 + phenotype and 10/15 also showed CD57 positivity .
11587224	0	CD56	50,54	DERL-2	42,48	CD56	DERL-2	4684	51009	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	Characterization of two novel cell lines , DERL-2 -LRB- CD56 + / CD3 + / Tcry5 + -RRB- and DERL-7 -LRB- CD56 + / CD3 - / TCRgammadelta - -RRB- , derived from a single patient with CD56 + non-Hodgkin 's _ lymphoma .
19621455	0	CD56	69,73	E-Cadherin	75,85	CD56	E-Cadherin	4684	999	Gene	Gene	phenotype|compound|START_ENTITY phenotype|dep|END_ENTITY	Congenital_aggressive variant of Langerhans cells histiocytosis with CD56 + / E-Cadherin - phenotype .
1382861	0	CD56	58,62	IL-6	0,4	CD56	IL-6	4684	3569	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells enhances|dobj|activity enhances|nsubj|END_ENTITY	IL-6 enhances the cytotoxic activity of thymocyte-derived CD56 + cells .
1717551	0	CD56	44,48	IL-7	11,15	CD56	IL-7	4684	3574	Gene	Gene	cells|compound|START_ENTITY Effects|nmod|cells Effects|nmod|END_ENTITY	Effects of IL-7 and IL-2 on highly enriched CD56 + natural killer cells .
7526680	0	CD56	19,23	N-CAM	25,30	CD56	N-CAM	4684	4684	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High expression of CD56 -LRB- N-CAM -RRB- in a patient with cutaneous CD4-positive lymphoma .
7684798	0	CD56	7,11	N-CAM	0,5	CD56	N-CAM	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	N-CAM -LRB- CD56 -RRB- expression by CD34 + malignant myeloblasts has implications for minimal residual disease detection in acute_myeloid_leukemia .
7692192	0	CD56	30,34	N-CAM	23,28	CD56	N-CAM	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of N-CAM -LRB- CD56 -RRB- adhesion molecule on myeloid and progenitor cells from chronic myeloid_leukemia .
10091945	0	CD56	0,4	NCAM	5,9	CD56	NCAM	4684	4684	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	CD56 -LRB- NCAM -RRB- antigen in glandular epithelium of human thyroid : light microscopic and ultrastructural study .
23292839	0	CD56	20,24	NCAM	14,18	CD56	NCAM	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of NCAM -LRB- CD56 -RRB- , chromogranin_A , synaptophysin , c-KIT -LRB- CD117 -RRB- and PDGFRA in normal non-neoplastic skin and basal_cell_carcinoma : an immunohistochemical study of 66 consecutive cases .
25889612	0	CD56	6,10	NCAM	0,4	CD56	NCAM	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	NCAM -LRB- CD56 -RRB- Expression in keratin-producing odontogenic cysts : aberrant expression in KCOT .
25889612	0	CD56	6,10	NCAM	0,4	CD56	NCAM	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	NCAM -LRB- CD56 -RRB- Expression in keratin-producing odontogenic cysts : aberrant expression in KCOT .
7532919	0	CD56	27,31	NCAM	33,37	CD56	NCAM	4684	4684	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Clinicopathologic study of CD56 -LRB- NCAM -RRB- - positive angiocentric_lymphoma occurring in sites other than the upper and lower respiratory tract .
8920872	0	CD56	40,44	NKR-P1A	31,38	CD56	NKR-P1A	4684	3820	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Definition of a natural killer NKR-P1A + / CD56 - / CD16 - functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12 .
23874793	0	CD56	152,156	NKp44	144,149	CD56	NKp44	4684	9436	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Natural killer cell cytokine response to M. _ bovis BCG Is associated with inhibited proliferation , increased apoptosis and ultimate depletion of NKp44 -LRB- + -RRB- CD56 -LRB- bright -RRB- cells .
11106230	0	CD56	91,95	P-glycoprotein	73,87	CD56	P-glycoprotein	4684	5243	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ END_ENTITY|nmod|lymphocytes	Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56 + lymphocytes after oral and intravenous administration .
11434506	0	CD56	128,132	P-glycoprotein	84,98	CD56	P-glycoprotein	4684	5243	Gene	Gene	cells|nummod|START_ENTITY associated|nmod|cells associated|nmod|efflux efflux|nmod|rhodamine_123 rhodamine_123|amod|END_ENTITY	The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine_123 from CD56 + natural killer cells .
15068897	0	CD56	48,52	P-glycoprotein	76,90	CD56	P-glycoprotein	4684	5243	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|overexpression overexpression|amod|END_ENTITY	Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid_leukemia .
22782455	0	CD56	72,76	P-glycoprotein	37,51	CD56	P-glycoprotein	4684	5243	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Increased expression and function of P-glycoprotein in peripheral blood CD56 + cells is associated with the chemoresistance of non-small-cell_lung_cancer .
9606993	0	CD56	65,69	RAG-2	47,52	CD56	RAG-2	4684	5897	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of CD3_epsilon , CD3_zeta , and RAG-1 / RAG-2 in decidual CD56 + NK cells .
22481022	0	CD56	24,28	TdT	19,22	CD56	TdT	4684	1791	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	Detection of CD34 , TdT , CD56 , CD2 , CD4 , and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically_normal_acute_myeloid_leukemia .
20231901	0	CD56	86,90	interferon-gamma	57,73	CD56	interferon-gamma	4684	3458	Gene	Gene	cells|compound|START_ENTITY IL-12-mediated|nmod|cells IL-12-mediated|dobj|response response|amod|END_ENTITY	Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users .
9194640	0	CD56	84,88	interferon-gamma	56,72	CD56	interferon-gamma	4684	3458	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Interleukin-12 - and interleukin-2-stimulated release of interferon-gamma by uterine CD56 + + large granular lymphocytes is amplified by decidual macrophages .
8639878	0	CD56	51,55	interleukin-15	8,22	CD56	interleukin-15	4684	3600	Gene	Gene	development|nmod|START_ENTITY END_ENTITY|nmod|development	Role of interleukin-15 in the development of human CD56 + natural killer cells from CD34 + hematopoietic progenitor cells .
15319390	0	CD56dimCD16	37,48	CD69	49,53	CD56dimCD16	CD69	4684;2214	969	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	An increase in the absolute count of CD56dimCD16 + CD69 + NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome .
11100948	0	CD57	111,115	CD16	116,120	CD57	CD16	27087	2214	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effects of occupational metallic mercury vapour exposure on suppressor-inducer -LRB- CD4 + CD45RA + -RRB- T lymphocytes and CD57 + CD16 + natural killer cells .
9009088	0	CD57	75,79	CD16	61,65	CD57	CD56	27087	4684	Gene	Gene	+|compound|START_ENTITY growth|appos|+ growth|amod|+ +|dep|END_ENTITY	Autocrine IL-2-dependent growth of a newly established CD3 + , CD16 - , CD56 + , CD57 + , J -LRB- H -RRB- - , TCRbeta - , TCRgamma - _ leukemia cell line -LRB- NOI-90 -RRB- .
9075840	0	CD57	76,80	CD28	83,87	CD57	CD28	27087	940	Gene	Gene	+|compound|START_ENTITY +|appos|cells cells|nummod|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9766502	0	CD57	0,4	CD28	6,10	CD57	CD28	27087	940	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|dep|END_ENTITY	CD57 + / CD28 - T cells in untreated hemato-oncological patients are expanded and display a Th1-type cytokine secretion profile , ex vivo cytolytic activity and enhanced tendency to apoptosis .
11757730	0	CD57	26,30	CD4	15,18	CD57	CD4	27087	920	Gene	Gene	+|compound|START_ENTITY CD8|dep|+ Association|parataxis|CD8 Association|nmod|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
16353293	0	CD57	52,56	CD4	47,50	CD57	CD4	27087	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cytokine gene expression profile distinguishes CD4 + / CD57 + T cells of the nodular lymphocyte predominance type of Hodgkin 's _ lymphoma from their tonsillar counterparts .
1828937	0	CD57	109,113	CD4	40,43	CD57	CD4	27087	920	Gene	Gene	lack|dobj|START_ENTITY cells|acl:relcl|lack cells|nmod|skin_lesions skin_lesions|nmod|mycosis_fungoides mycosis_fungoides|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
21491089	0	CD57	42,46	CD4	38,41	CD57	CD4	27087	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Altered cytokine levels and increased CD4 + CD57 + T cells in the peripheral blood of hepatitis_C_virus-related hepatocellular_carcinoma patients .
21491089	8	CD57	1303,1307	CD4	1299,1302	CD57	CD4	27087	920	Gene	Gene	abTCR|compound|START_ENTITY abTCR|compound|END_ENTITY	The percentage of CD4 + CD57 + abTCR + cells -LRB- CD4 + CD57 + T cells -RRB- in peripheral blood lymphocytes -LRB- PBLs -RRB- increased with tumor progression .
24291117	0	CD57	9,13	CD4	72,75	CD57	CD4	27087	920	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|numbers numbers|nmod|responders responders|nummod|END_ENTITY	Elevated CD57 and CD95 expressions are associated with lower numbers of CD4 ____ recent_thymic_emigrants_in_HIV-1_infected immune responders following antiretroviral treatment .
7541727	0	CD57	4,8	CD4	0,3	CD57	CD4	27087	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD57 + T cells derived from peripheral blood do not support immunoglobulin production by B cells .
9013995	0	CD57	32,36	CD4	28,31	CD57	CD4	27087	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Clonal expansion within the CD4 + CD57 + and CD8 + CD57 + T cell subsets in chronic_lymphocytic_leukemia .
9108401	0	CD57	17,21	CD4	12,15	CD57	CD4	27087	920	Gene	Gene	expansions|compound|START_ENTITY expansions|compound|END_ENTITY	Oligoclonal CD4 + CD57 + T-cell expansions contribute to the imbalanced T-cell receptor repertoire of rheumatoid_arthritis patients .
11757730	0	CD57	26,30	CD56	20,24	CD57	CD56	27087	4684	Gene	Gene	+|compound|START_ENTITY CD8|dep|+ CD8|nsubj|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12562330	0	CD57	139,143	CD56	133,137	CD57	CD56	27087	4684	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
12562330	0	CD57	163,167	CD56	112,116	CD57	CD56	27087	4684	Gene	Gene	T|compound|START_ENTITY characterization|dep|T characterization|nmod|markers markers|appos|CD57 CD57|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
24959961	0	CD57	96,100	CD56	103,107	CD57	CD56	27087	4684	Gene	Gene	loss|nmod|START_ENTITY subset|dep|loss subset|compound|END_ENTITY	Impaired natural killer cell responses are associated with loss of the highly activated NKG2A -LRB- + -RRB- CD57 -LRB- + -RRB- CD56 -LRB- dim -RRB- subset in HIV-1_subtype_D_infection in Uganda .
25472612	0	CD57	29,33	CD56	14,18	CD57	CD56	27087	4684	Gene	Gene	+|compound|START_ENTITY NK|nsubj|+ +|xcomp|NK +|nsubj|Enrichment Enrichment|nmod|KIR KIR|compound|END_ENTITY	Enrichment of CD56 -LRB- dim -RRB- KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients .
26416461	0	CD57	9,13	CD56	0,4	CD57	CD56	27087	4684	Gene	Gene	NKG2C|compound|START_ENTITY NK|nsubj|NKG2C NK|nsubj|END_ENTITY	CD56 -LRB- dim -RRB- CD57 -LRB- + -RRB- NKG2C -LRB- + -RRB- NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT .
10025897	0	CD57	62,66	CD8	57,60	CD57	CD8	27087	925	Gene	Gene	counterpart|compound|START_ENTITY counterpart|compound|END_ENTITY	Leukemic CD3 + LGL share functional properties with their CD8 + CD57 + cell counterpart expanded after BMT .
10583606	0	CD57	90,94	CD8	102,105	CD57	CD8	27087	925	Gene	Gene	CD28|compound|START_ENTITY lymphocytes|nmod|CD28 population|dep|lymphocytes population|compound|END_ENTITY	Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57 + CD28 - CD8 + T-cell population .
10765928	0	CD57	6,10	CD8	0,3	CD57	CD8	27087	925	Gene	Gene	cells|appos|START_ENTITY cells|compound|END_ENTITY	CD8 + , CD57 + T cells from healthy elderly subjects suppress neutrophil development in vitro : implications for the neutropenia of Felty 's and large granular lymphocyte syndromes .
11757730	0	CD57	26,30	CD8	32,35	CD57	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12433688	0	CD57	14,18	CD8	89,92	CD57	CD8	27087	925	Gene	Gene	Expression|nmod|START_ENTITY defines|nsubj|Expression defines|dobj|senescence senescence|nmod|cells cells|compound|END_ENTITY	Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8 + T cells .
12562330	0	CD57	118,122	CD8	58,61	CD57	CD8	27087	925	Gene	Gene	markers|appos|START_ENTITY characterization|nmod|markers characterization|nmod|subsets subsets|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
12562330	0	CD57	163,167	CD8	58,61	CD57	CD8	27087	925	Gene	Gene	T|compound|START_ENTITY characterization|dep|T characterization|nmod|subsets subsets|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
15879103	0	CD57	163,167	CD8	76,79	CD57	CD8	27087	925	Gene	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|Expression Expression|nmod|T T|compound|END_ENTITY	Expression of killer_cell_lectin-like_receptor_G1 on antigen-specific human CD8 + T lymphocytes during active , latent , and resolved_infection and its relation with CD57 .
16290071	6	CD57	765,769	CD8	761,764	CD57	CD8	27087	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD8 + CD57 + lymphocytes in normal and HIV-infected subjects underwent more apoptosis than CD8 + CD57 - cells .
16649379	0	CD57	40,44	CD8	71,74	CD57	CD8	27087	925	Gene	Gene	subset|compound|START_ENTITY subset|nmod|T T|compound|END_ENTITY	Increased activation and expansion of a CD57 + subset within peripheral CD8 + T lymphocytes in Mycobacterium_tuberculosis-infected patients .
16805321	0	CD57	28,32	CD8	24,27	CD57	CD8	27087	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|nummod|END_ENTITY	Increase of circulating CD8 + CD57 + lymphocytes after measles_infection but not after measles vaccination .
1707006	0	CD57	48,52	CD8	44,47	CD57	CD8	27087	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	A lectin-binding soluble factor released by CD8 + CD57 + lymphocytes from AIDS patients inhibits T cell cytotoxicity .
1709378	0	CD57	33,37	CD8	29,32	CD57	CD8	27087	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	A soluble factor released by CD8 + CD57 + lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis .
17626255	0	CD57	39,43	CD8	34,37	CD57	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY T-cell|nsubj|+ expansion|parataxis|T-cell expansion|nmod|+ +|compound|END_ENTITY	Transient monoclonal expansion of CD8 + / CD57 + T-cell large granular lymphocytes after primary cytomegalovirus_infection .
1828385	0	CD57	25,29	CD8	21,24	CD57	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Inhibitor effect of CD8 + CD57 + lymphocytes on cell-mediated cytotoxicity : characterization of suppressor factor -RSB- .
1828937	0	CD57	109,113	CD8	5,8	CD57	CD8	27087	925	Gene	Gene	lack|dobj|START_ENTITY cells|acl:relcl|lack cells|nsubj|cells cells|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
19646341	0	CD57	14,18	CD8	151,154	CD57	CD8	27087	925	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|evidence evidence|nmod|activation activation|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Expression of CD57 on CD8 + T lymphocytes of patients with Wegener 's _ granulomatosis and microscopic_polyangiitis : evidence for continuous activation of CD8 + cells .
19646341	0	CD57	14,18	CD8	22,25	CD57	CD8	27087	925	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Expression of CD57 on CD8 + T lymphocytes of patients with Wegener 's _ granulomatosis and microscopic_polyangiitis : evidence for continuous activation of CD8 + cells .
20385876	0	CD57	59,63	CD8	54,57	CD57	CD8	27087	925	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The small heat_shock protein 27 is a key regulator of CD8 + CD57 + lymphocyte survival .
21711350	0	CD57	20,24	CD8	15,18	CD57	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD8 + CD28 - and CD8 + CD57 + T cells and their role in health and disease .
22307139	0	CD57	58,62	CD8	52,55	CD57	CD8	27087	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Detection and characterization of a novel subset of CD8 CD57 T cells in metastatic melanoma with an incompletely differentiated phenotype .
22789311	0	CD57	17,21	CD8	12,15	CD57	CD8	27087	925	Gene	Gene	T|compound|START_ENTITY +|dep|T +|compound|END_ENTITY	-LSB- Polyclonal CD8 + / CD57 + T cell expansions : clinical significance -RSB- .
23355208	0	CD57	26,30	CD8	22,25	CD57	CD8	27087	925	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Expansion of a clonal CD8 + CD57 + large granular lymphocyte population after autologous stem cell transplant in multiple myeloma .
24533103	0	CD57	88,92	CD8	30,33	CD57	CD8	27087	925	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells due|nmod|expansion SEB|xcomp|due improves|xcomp|SEB improves|dobj|response response|compound|END_ENTITY	CMV latent_infection improves CD8 + T response to SEB due to expansion of polyfunctional CD57 + cells in young individuals .
24585893	0	CD57	49,53	CD8	25,28	CD57	CD8	27087	925	Gene	Gene	reversed|nsubjpass|START_ENTITY expressing|ccomp|reversed cells|acl|expressing cells|nummod|END_ENTITY	Low proportions of CD28 - CD8 + T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV_infection .
24586783	0	CD57	29,33	CD8	17,20	CD57	CD8	27087	925	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Impact of HIV on CD8 + T cell CD57 expression is distinct from that of CMV and aging .
24868535	0	CD57	52,56	CD8	48,51	CD57	CD8	27087	925	Gene	Gene	expansion|compound|START_ENTITY expansion|compound|END_ENTITY	Low perceived social support is associated with CD8 + CD57 + lymphocyte expansion and increased TNF-a levels .
25100841	0	CD57	35,39	CD8	41,44	CD57	CD8	27087	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
25100841	0	CD57	35,39	CD8	67,70	CD57	CD8	27087	925	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells identifies|nsubj|expression identifies|dobj|subset subset|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
26761268	0	CD57	86,90	CD8	13,16	CD57	CD8	27087	925	Gene	Gene	Expression|nmod|START_ENTITY Correlates|nmod|Expression +|dobj|Correlates +|nsubj|END_ENTITY	HIV-Specific CD8 + T Cell-Mediated Viral Suppression Correlates With the Expression of CD57 .
7511079	0	CD57	169,173	CD8	164,167	CD57	CD8	27087	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8_lymphocytosis in primary cytomegalovirus _ -LRB- CMV -RRB- _ infection of allograft recipients : expansion of an uncommon CD8 + CD57 - subset and its progressive replacement by CD8 + CD57 + T cells .
7511468	0	CD57	13,17	CD8	9,12	CD57	CD8	27087	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Alveolar CD8 + CD57 + lymphocytes in human_immunodeficiency_virus_infection produce an inhibitor of cytotoxic functions .
7522602	0	CD57	45,49	CD8	41,44	CD57	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes in the level of blood suppressor CD8 + CD57 + lymphocytes , when HIV-1 p24 antigen reappears in the blood .
7525310	0	CD57	52,56	CD8	48,51	CD57	CD8	27087	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	An inhibitor of cytotoxic functions produced by CD8 + CD57 + T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients .
7538544	0	CD57	60,64	CD8	12,15	CD57	CD8	27087	925	Gene	Gene	subset|compound|START_ENTITY expanded|nmod|subset expanded|nsubjpass|cells cells|compound|END_ENTITY	Oligoclonal CD8 + T cells are preferentially expanded in the CD57 + subset .
7540855	0	CD57	17,21	CD8	13,16	CD57	CD8	27087	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion of CD8 + CD57 + T cells after allogeneic BMT is related with a low incidence of relapse and with cytomegalovirus_infection .
7561518	0	CD57	29,33	CD8	34,37	CD57	CD8	27087	925	Gene	Gene	expression|nmod|START_ENTITY +|nsubj|expression +|dobj|cells cells|nummod|END_ENTITY	Enhanced expression of novel CD57 + CD8 + LAK cells from cats infected with feline_immunodeficiency_virus .
7682534	0	CD57	83,87	CD8	78,81	CD57	CD8	27087	925	Gene	Gene	hybridoma|compound|START_ENTITY hybridoma|compound|END_ENTITY	Purification and partial amino_acid sequence of suppressive lymphokine from a CD8 + CD57 + human T hybridoma .
7693383	0	CD57	17,21	CD8	11,14	CD57	CD8	27087	925	Gene	Gene	cells|nummod|START_ENTITY +|appos|cells +|compound|END_ENTITY	Subsets of CD8 + , CD57 + cells in normal , healthy individuals : correlations with human_cytomegalovirus _ -LRB- HCMV -RRB- carrier status , phenotypic and functional analyses .
9013995	0	CD57	46,50	CD8	42,45	CD57	CD8	27087	925	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Clonal expansion within the CD4 + CD57 + and CD8 + CD57 + T cell subsets in chronic_lymphocytic_leukemia .
9075840	0	CD57	115,119	CD8	145,148	CD57	CD8	27087	925	Gene	Gene	expansion|nmod|START_ENTITY cells|nmod|expansion +|appos|cells mobilization|nmod|+ response|dep|mobilization response|dep|cells cells|nmod|compartment compartment|compound|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9075840	0	CD57	76,80	CD8	145,148	CD57	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY mobilization|nmod|+ response|dep|mobilization response|dep|cells cells|nmod|compartment compartment|compound|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9504628	0	CD57	5,9	CD8	0,3	CD57	CD8	27087	925	Gene	Gene	cells|compound|START_ENTITY suppress|nsubj|cells +|parataxis|suppress +|compound|END_ENTITY	CD8 + / CD57 cells and apoptosis suppress T-cell functions in multiple_myeloma .
9543594	0	CD57	99,103	CD8	95,98	CD57	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Membranoproliferative_glomerulonephritis in the aged and its possible causal relationship with CD8 + CD57 + lymphocytes .
12687271	0	CD57	48,52	chromogranin_A	22,36	CD57	chromogranin A	27087	1113	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Different patterns of chromogranin_A and Leu-7 -LRB- CD57 -RRB- expression in gastrointestinal_carcinoids : immunohistochemical and confocal laser scanning microscopy study .
25100841	0	CD57	35,39	eomesodermin	5,17	CD57	eomesodermin	27087	8320	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
7528777	0	CD58	86,90	CD2	116,119	CD58	CD2	965	914	Gene	Gene	required|dep|START_ENTITY required|nmod|END_ENTITY	Amino_acid residues required for binding of lymphocyte function-associated antigen 3 -LRB- CD58 -RRB- to its counter-receptor CD2 .
1372880	0	CD58	68,72	ICAM1	23,28	CD58	ICAM1	965	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of ICAM1 -LRB- CD54 -RRB- and minimal expression of LFA3 -LRB- CD58 -RRB- in Epstein-Barr-virus-positive nasopharyngeal_carcinoma cells .
10959555	0	CD58	21,25	LFA-3	14,19	CD58	LFA-3	965	965	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of LFA-3 -LRB- CD58 -RRB- by dexamethasone and retinoic_acids in vitro .
11812190	0	CD58	43,47	P53	0,3	CD58	P53	965	7157	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	P53 possibly upregulates the expression of CD58 -LRB- LFA-3 -RRB- and CD59 -LRB- MIRL -RRB- .
12482338	0	CD59	30,34	CD34	22,26	CD59	CD34	966	947	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Ex vivo expansion of CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from bone marrow of paroxysmal_nocturnal_hemoglobinuria patients -RSB- .
12744742	0	CD59	93,97	CD34	86,90	CD59	CD34	966	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	-LSB- Application of double immunomagnetic positive sorting to ex vivo expansion of marrow CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
18261338	0	CD59	47,51	CD34	40,44	CD59	CD34	966	947	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Long-term ability for hematopoiesis of CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from patients with paroxysmal_nocturnal_hemoglobinuria : experiment with mice -RSB- .
23965874	0	CD59	50,54	CD34	43,47	CD59	CD34	966	947	Gene	Gene	START_ENTITY|nsubj|expansion expansion|nmod|END_ENTITY	-LSB- Ex vivo expansion and clonal variation of CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- cells from bone marrow in children with paroxysmal_nocturnal_hemoglobinuria -RSB- .
8690053	0	CD59	44,48	CD34	72,76	CD59	CD34	966	947	Gene	Gene	epitope|nmod|START_ENTITY expression|nmod|epitope identifies|nsubj|expression identifies|dobj|subset subset|nmod|cells cells|nummod|END_ENTITY	High-level expression of a novel epitope of CD59 identifies a subset of CD34 + bone marrow cells highly enriched for pluripotent stem cells .
16563273	0	CD59	55,59	CD55	49,53	CD59	CD59	966	966	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|nmod|expression expression|nmod|END_ENTITY	-LSB- The effect of atorvastatin on the expression of CD55 , CD59 in patients with hyperlipidemia -RSB- .
1382994	0	CD59	88,92	HRF20	81,86	CD59	HRF20	966	966	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Paroxysmal_nocturnal_hemoglobinuria due to hereditary nucleotide deletion in the HRF20 -LRB- CD59 -RRB- gene .
9159406	0	CD59	28,32	HRF20	21,26	CD59	HRF20	966	966	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Unique expression of HRF20 -LRB- CD59 -RRB- in human nervous tissue .
22093990	0	CD59	87,91	STAT5	1,6	CD59	STAT5	966	6776	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	-LSB- STAT5 phosphorylation levels of erythropoietin and thrombopoietin_receptors in CD34 -LRB- + -RRB- CD59 -LRB- - -RRB- and CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- bone marrow cells of patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
10850450	0	CD59	0,4	decay-accelerating_factor	49,74	CD59	decay-accelerating factor	25407(Tax:10116)	1604	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	CD59 expressed on a tumor cell surface modulates decay-accelerating_factor expression and enhances tumor growth in a rat model of human neuroblastoma .
22093990	0	CD59	87,91	erythropoietin	33,47	CD59	erythropoietin	966	2056	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	-LSB- STAT5 phosphorylation levels of erythropoietin and thrombopoietin_receptors in CD34 -LRB- + -RRB- CD59 -LRB- - -RRB- and CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- bone marrow cells of patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
21083881	0	CD59	74,78	kininogen-1	80,91	CD59	kininogen-1	966	3827	Gene	Gene	urine|nummod|START_ENTITY urine|nummod|END_ENTITY	Patients with ovarian_carcinoma excrete different altered levels of urine CD59 , kininogen-1 and fragments of inter-alpha-trypsin inhibitor heavy chain H4 and albumin .
8759753	0	CD59	107,111	membrane_inhibitor_of_reactive_lysis	69,105	CD59	membrane inhibitor of reactive lysis	966	966	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Analysis of the gene that encodes the complement regulatory protein , membrane_inhibitor_of_reactive_lysis -LRB- CD59 -RRB- .
10667419	0	CD59	35,39	protectin	24,33	CD59	protectin	966	966	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of protectin -LRB- CD59 -RRB- in gut epithelium in ulcerative_colitis and Crohn 's _ disease .
10958054	0	CD59	28,32	protectin	17,26	CD59	protectin	966	966	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Emerging role of protectin -LRB- CD59 -RRB- in humoral immunotherapy of solid malignancies .
11056001	0	CD59	29,33	protectin	18,27	CD59	protectin	966	966	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of protectin -LRB- CD59 -RRB- down-modulates the susceptibility of human melanoma cells to homologous complement .
7538980	0	CD59	25,29	protectin	14,23	CD59	protectin	966	966	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of protectin -LRB- CD59 -RRB- in human melanoma and its functional role in cell - and complement-mediated cytotoxicity .
16301611	0	CD59a	21,26	CD4	47,50	CD59a	CD4	12509(Tax:10090)	12504(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	Cutting edge : murine CD59a modulates antiviral CD4 + T cell activity in a complement-independent manner .
15493268	0	CD6	14,17	p180	46,50	CD6	p180	923	5422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD6 and the UCHL1-defined CD45 -LRB- p180 -RRB- antigen by human colonic T lymphocytes .
16034076	0	CD6	24,27	syntenin-1	43,53	CD6	syntenin-1	923	6386	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The lymphocyte receptor CD6 interacts with syntenin-1 , a scaffolding protein containing PDZ domains .
19099641	0	CD61	26,30	CD34	21,25	CD61	CD34	3690	947	Gene	Gene	precursors|compound|START_ENTITY precursors|compound|END_ENTITY	-LSB- Correlation between CD34 + CD61 + megakaryocyte precursors and platelet engraftment in allogeneic hematopoietic stem cell transplantation -RSB- .
22378601	0	CD61	84,88	CD34	44,48	CD61	CD34	16416(Tax:10090)	12490(Tax:10090)	Gene	Gene	cells|dep|START_ENTITY identifies|dobj|cells identifies|nsubj|characterization characterization|nmod|cells cells|compound|END_ENTITY	Functional characterization of TPO-expanded CD34 + cord blood cells identifies CD34 - CD61 - cells as platelet-producing cells early after transplantation in NOD/SCID mice and rCD34 + cells as CAFC colony-forming cells .
22378601	0	CD61	84,88	CD34	78,82	CD61	CD34	16416(Tax:10090)	12490(Tax:10090)	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Functional characterization of TPO-expanded CD34 + cord blood cells identifies CD34 - CD61 - cells as platelet-producing cells early after transplantation in NOD/SCID mice and rCD34 + cells as CAFC colony-forming cells .
1721534	0	CD62	27,31	GMP-140	18,25	CD62	GMP-140	6403	6403	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Downregulation of GMP-140 -LRB- CD62 or PADGEM -RRB- expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine .
7511947	0	CD62	65,69	Granulocyte_colony-stimulating_factor	0,37	CD62	Granulocyte colony-stimulating factor	6403	1440	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor enhances the expression of CD62 on platelets in vivo .
10694482	0	CD62	91,95	P-selectin	79,89	CD62	P-selectin	6403	6403	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Flow cytometric parameters for characterizing platelet activation by measuring P-selectin -LRB- CD62 -RRB- expression : theoretical consideration and evaluation in thrombin-treated platelet populations .
11123285	0	CD62E	76,81	CD4	113,116	CD62E	CD4	6401	920	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
11123285	0	CD62E	76,81	E-selectin	64,74	CD62E	E-selectin	6401	6401	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
18472945	0	CD62E	60,65	E-selectin	48,58	CD62E	E-selectin	6401	6401	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Serum Concentration and Chemotactic Activity of E-selectin -LRB- CD62E -RRB- in Inflammatory_Bowel_Disease .
9218615	0	CD62E	78,83	E-selectin	66,76	CD62E	E-selectin	6401	6401	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin -LRB- CD62E -RRB- does not promote their activation .
19837408	0	CD62L	23,28	Angiotensin_II	0,14	CD62L	Angiotensin II	6402	183	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces CD62L shedding in human neutrophils .
15546950	0	CD62L	9,14	CD25	37,41	CD62L	CD25	20343(Tax:10090)	16184(Tax:10090)	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|nmod|cells cells|compound|END_ENTITY	Only the CD62L + subpopulation of CD4 + CD25 + regulatory T cells protects from lethal acute GVHD .
17627234	0	CD62L	104,109	CD25	88,92	CD62L	CD25	6402	3559	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4 + CD25 + GITR+F oxp3 + CD62L + functional regulatory T-cells in patients with graft-versus-host_disease .
18724229	0	CD62L	53,58	CD25	48,52	CD62L	CD25	6402	3669	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Interferon-gamma conditioning ex vivo generates CD25 + CD62L + Foxp3 + regulatory T cells that prevent allograft rejection : potential avenues for cellular therapy .
26693907	0	CD62L	73,78	CD25	23,27	CD62L	CD25	20343(Tax:10090)	16184(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Loss|nmod|Expression +|nmod|Loss +|nsubj|Freeze Freeze|nmod|Foxp3 Foxp3|compound|END_ENTITY	Freeze and Thaw of CD4 + CD25 + Foxp3 + Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host_Disease .
14990114	0	CD62L	27,32	CD34	22,26	CD62L	CD34	6402	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effect of numbers of CD34 + CD62L + cells infused on unrelated umbilical cord blood transplantation in children with acute_leukemia -RSB- .
11979045	0	CD62L	98,103	CD4	48,51	CD62L	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|dep|START_ENTITY phenotype|amod|+ expressing|dobj|phenotype +|parataxis|expressing +|nsubj|role role|nmod|interleukin-10 interleukin-10|nmod|generation generation|nmod|+ +|compound|END_ENTITY	The role of interleukin-10 in the generation of CD4 + and CD8 + memory_T cells -LRB- expressing a CD44 + , CD62L - phenotype -RRB- and their contribution to the regulation of immunoglobulin E antibody formation .
12355444	0	CD62L	51,56	CD4	77,80	CD62L	CD4	6402	12504(Tax:10090)	Gene	Gene	L-selectin|appos|START_ENTITY L-selectin|nmod|cells cells|compound|END_ENTITY	Inhibition of TCR-mediated shedding of L-selectin -LRB- CD62L -RRB- on human and mouse CD4 + T cells by metalloproteinase inhibition : analysis of the regulation of Th1/Th2 function .
12496379	0	CD62L	26,31	CD4	79,82	CD62L	CD4	6402	920	Gene	Gene	expression|appos|START_ENTITY edge|dep|expression Cutting|dobj|edge Cutting|nsubj|cells cells|nummod|END_ENTITY	Cutting edge : L-selectin -LRB- CD62L -RRB- expression distinguishes small resting memory CD4 + T cells that preferentially respond to recall antigen .
12571422	0	CD62L	76,81	CD4	83,86	CD62L	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A new model of chronic_colitis in SCID mice induced by adoptive transfer of CD62L + CD4 + T cells : insights into the regulatory role of interleukin-6 on apoptosis .
15546950	0	CD62L	9,14	CD4	33,36	CD62L	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	subpopulation|compound|START_ENTITY subpopulation|nmod|cells cells|compound|END_ENTITY	Only the CD62L + subpopulation of CD4 + CD25 + regulatory T cells protects from lethal acute GVHD .
16378987	0	CD62L	73,78	CD4	80,83	CD62L	CD4	6402	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	R5 variants of human_immunodeficiency_virus_type_1 preferentially infect CD62L - CD4 + T cells and are potentially resistant to nucleoside reverse transcriptase inhibitors .
17627234	0	CD62L	104,109	CD4	84,87	CD62L	CD4	6402	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4 + CD25 + GITR+F oxp3 + CD62L + functional regulatory T-cells in patients with graft-versus-host_disease .
18977182	0	CD62L	77,82	CD4	62,65	CD62L	CD4	6402	920	Gene	Gene	T|nsubj|START_ENTITY T|nmod|childhood childhood|dep|alterations alterations|nmod|CD45RA CD45RA|compound|END_ENTITY	Thymectomy in early childhood : significant alterations of the CD4 -LRB- + -RRB- CD45RA -LRB- + -RRB- CD62L -LRB- + -RRB- T cell compartment in later life .
19462221	0	CD62L	14,19	CD4	29,32	CD62L	CD4	6402	920	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Expression of CD62L on donor CD4 -LRB- + -RRB- T cells in allografts : correlation with graft-versus-host_disease after unmanipulated allogeneic blood and marrow transplantation .
19766669	0	CD62L	0,5	CD4	51,54	CD62L	CD4	6402	407098(Tax:9913)	Gene	Gene	defines|nsubj|START_ENTITY defines|dobj|subset subset|nmod|END_ENTITY	CD62L defines a subset of pathogen-specific bovine CD4 with central memory cell characteristics .
19919293	0	CD62L	27,32	CD4	8,11	CD62L	CD4	6402	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Role of CD4 + CD25 + highFoxp3 + CD62L + regulatory T cells and invariant NKT cells in human allogeneic hematopoietic stem cell transplantation .
23319734	0	CD62L	81,86	CD4	102,105	CD62L	CD4	6402	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Mitochondrial superoxide generation enhances P2X7R-mediated loss of cell surface CD62L on naive human CD4 + T lymphocytes .
23747992	0	CD62L	18,23	CD4	25,28	CD62L	CD4	6402	920	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Increased CD45RO + CD62L + CD4 + T-cell subpopulation responsible for Th2 response in Kimura 's _ disease .
25330112	0	CD62L	53,58	CD4	98,101	CD62L	CD4	6402	920	Gene	Gene	Activity|nmod|START_ENTITY Suppression|nmod|Activity Suppression|nmod|Cells Cells|compound|END_ENTITY	Suppression of Foxo1 Activity and Down-Modulation of CD62L -LRB- L-Selectin -RRB- in HIV-1 Infected Resting CD4 T Cells .
26518933	0	CD62L	65,70	CD4	40,43	CD62L	CD4	6402	920	Gene	Gene	CD25|dobj|START_ENTITY CD25|nsubj|END_ENTITY	Activated Regulatory T Cells Expressing CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD45RO -LRB- + -RRB- CD62L -LRB- + -RRB- Biomarkers Could Be a Risk Factor in Liver Allograft Rejection .
26693907	0	CD62L	73,78	CD4	19,22	CD62L	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Loss|nmod|Expression +|nmod|Loss +|nsubj|Freeze Freeze|nmod|Foxp3 Foxp3|compound|END_ENTITY	Freeze and Thaw of CD4 + CD25 + Foxp3 + Regulatory T Cells Results in Loss of CD62L Expression and a Reduced Capacity to Protect against Graft-versus-Host_Disease .
7529973	0	CD62L	44,49	CD4	40,43	CD62L	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	homing|compound|START_ENTITY homing|compound|END_ENTITY	Steroid receptor-mediated modulation of CD4 + CD62L + cell homing .
8698378	0	CD62L	26,31	CD4	91,94	CD62L	CD4	6402	920	Gene	Gene	Expression|appos|START_ENTITY discriminates|nsubj|Expression discriminates|dobj|cells cells|compound|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
12718752	0	CD62L	34,39	CD62L	91,96	CD62L	CD62L	6402	6402	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD62L	91,96	CD62L	34,39	CD62L	CD62L	6402	6402	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
11090146	0	CD62L	88,93	CD8	61,64	CD62L	CD8	20343(Tax:10090)	925	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Enrichment of immediate-early 1 -LRB- m123/pp89 -RRB- peptide-specific CD8 T cells in a pulmonary CD62L -LRB- lo -RRB- memory-effector cell pool during latent murine_cytomegalovirus infection of the lungs .
12496450	0	CD62L	35,40	CD8	15,18	CD62L	CD8	6402	925	Gene	Gene	+|compound|START_ENTITY phenotype|nummod|+ cells|nmod|phenotype cells|compound|END_ENTITY	IL-4-producing CD8 + T cells with a CD62L + + -LRB- bright -RRB- phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age .
12718752	0	CD62L	34,39	CD8	41,44	CD62L	CD8	6402	925	Gene	Gene	START_ENTITY|dep|cells cells|nummod|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD62L	34,39	CD8	98,101	CD62L	CD8	6402	925	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD62L	91,96	CD8	41,44	CD62L	CD8	6402	925	Gene	Gene	cells|compound|START_ENTITY CD62L|dep|cells CD62L|dep|cells cells|nummod|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD62L	91,96	CD8	98,101	CD62L	CD8	6402	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
14978076	8	CD62L	1081,1086	CD8	1090,1093	CD62L	CD8	6402	925	Gene	Gene	periphery|appos|START_ENTITY seeded|nmod|periphery patrol|advcl|seeded patrol|nsubj|cells cells|compound|END_ENTITY	Once seeded in the periphery , naive CCR7 -LRB- + -RRB- CD62L -LRB- + -RRB- CD8 T cells patrol secondary lymphoid organs , whereas naive CCR7 -LRB- - -RRB- CD62L -LRB- - -RRB- CD8 T cells selectively migrate to peripheral tissues such as skin .
20972785	0	CD62L	38,43	CD8	51,54	CD62L	CD8	6402	925	Gene	Gene	START_ENTITY|dobj|cells cells|compound|END_ENTITY	Primed tumor-reactive multifunctional CD62L + human CD8 + T cells for immunotherapy .
25330112	0	CD62L	53,58	Foxo1	15,20	CD62L	Foxo1	6402	2308	Gene	Gene	Activity|nmod|START_ENTITY Activity|amod|END_ENTITY	Suppression of Foxo1 Activity and Down-Modulation of CD62L -LRB- L-Selectin -RRB- in HIV-1 Infected Resting CD4 T Cells .
12406901	0	CD62L	91,96	Granulocyte-colony_stimulating_factor	0,37	CD62L	Granulocyte-colony stimulating factor	6402	1440	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Granulocyte-colony_stimulating_factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression .
10529600	0	CD62L	27,32	Interferon-gamma	0,16	CD62L	Interferon-gamma	6402	3458	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Interferon-gamma increases CD62L expression on human eosinophils .
10622231	0	CD62L	80,85	L-selectin	68,78	CD62L	L-selectin	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inverse association between endogenous glucocorticoid secretion and L-selectin -LRB- CD62L -RRB- expression in trauma patients .
10733478	0	CD62L	50,55	L-selectin	38,48	CD62L	L-selectin	6402	6402	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Circulating concentrations of soluble L-selectin -LRB- CD62L -RRB- in patients with primary Sj __ gren 's _ syndrome .
12496379	0	CD62L	26,31	L-selectin	14,24	CD62L	L-selectin	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cutting edge : L-selectin -LRB- CD62L -RRB- expression distinguishes small resting memory CD4 + T cells that preferentially respond to recall antigen .
12580810	0	CD62L	67,72	L-selectin	55,65	CD62L	L-selectin	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Decreased intercellular_adhesion_molecule-1 -LRB- CD54 -RRB- and L-selectin -LRB- CD62L -RRB- expression on peripheral blood natural killer cells in asthmatic children with acute exacerbation .
14667200	0	CD62L	16,21	L-selectin	4,14	CD62L	L-selectin	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Low L-selectin -LRB- CD62L -RRB- expression in acute_myeloid_leukemia correlates with a bad cytogenetic risk .
15776384	0	CD62L	22,27	L-selectin	10,20	CD62L	L-selectin	6402	6402	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of L-selectin -LRB- CD62L -RRB- on human leukocytes in disseminated_cryptococcosis_with_and_without_associated_HIV-1_infection .
16788684	0	CD62L	153,158	L-selectin	141,151	CD62L	L-selectin	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Apoptotic lymphocytes and CD34 + cells in cryopreserved cord blood detected by the fluorescent vital dye SYTO 16 and correlation with loss of L-selectin -LRB- CD62L -RRB- expression .
19240088	0	CD62L	35,40	L-selectin	23,33	CD62L	L-selectin	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cyclical expression of L-selectin -LRB- CD62L -RRB- by recirculating T cells .
7543141	0	CD62L	76,81	L-selectin	64,74	CD62L	L-selectin	6402	6402	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Structural requirements regulate endoproteolytic release of the L-selectin -LRB- CD62L -RRB- adhesion receptor from the cell surface of leukocytes .
7591847	0	CD62L	36,41	L-selectin	24,34	CD62L	L-selectin	6402	6402	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Spatial distribution of L-selectin -LRB- CD62L -RRB- on human lymphocytes and transfected murine L1-2 cells .
8698378	0	CD62L	26,31	L-selectin	14,24	CD62L	L-selectin	6402	6402	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
9038755	0	CD62L	49,54	L-selectin	37,47	CD62L	L-selectin	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differential regulation of leucocyte L-selectin -LRB- CD62L -RRB- expression in normal lymphoid and inflamed extralymphoid tissues .
9422729	0	CD62L	45,50	L-selectin	33,43	CD62L	L-selectin	6402	6402	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Affinity and kinetic analysis of L-selectin -LRB- CD62L -RRB- binding to glycosylation-dependent cell-adhesion molecule-1 .
12571422	0	CD62L	76,81	interleukin-6	134,147	CD62L	interleukin-6	20343(Tax:10090)	16193(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY transfer|nmod|cells induced|nmod|transfer mice|acl|induced chronic_colitis|nmod|mice model|nmod|chronic_colitis model|dep|insights insights|nmod|role role|nmod|END_ENTITY	A new model of chronic_colitis in SCID mice induced by adoptive transfer of CD62L + CD4 + T cells : insights into the regulatory role of interleukin-6 on apoptosis .
26102172	0	CD62P	12,17	P-Selectin	0,10	CD62P	P-Selectin	6403	6403	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	P-Selectin -LRB- CD62P -RRB- Expression in Liver Tissue of Biliary_Atresia : A New Perspective in Etiopathogenesis .
10397916	0	CD62P	35,40	P-selectin	23,33	CD62P	P-selectin	6403	6403	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of P-selectin -LRB- CD62P -RRB- by endothelial cells seeded onto synthetic arterial prostheses -LRB- PET , Dacron -RRB- is correlated with leukocyte interactions .
12543548	0	CD62P	16,21	P-selectin	23,33	CD62P	P-selectin	100009695(Tax:9796)	6403	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Equine platelet CD62P -LRB- P-selectin -RRB- expression : a phenotypic and morphologic study .
15166936	0	CD62P	79,84	P-selectin	67,77	CD62P	P-selectin	6403	6403	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The effect of hormone replacement therapy on Ca2 + mobilization and P-selectin -LRB- CD62P -RRB- expression in platelets examined under flow cytometry .
18482194	0	CD62P	31,36	P-selectin	38,48	CD62P	P-selectin	6403	6403	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Flow cytometric measurement of CD62P -LRB- P-selectin -RRB- expression on platelets : a multicenter optimization and standardization effort .
21245745	0	CD62P	64,69	P-selectin	52,62	CD62P	P-selectin	6403	6403	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Platelet function alterations and their relation to P-selectin -LRB- CD62P -RRB- expression in children with iron_deficiency anemia .
23484959	0	CD62P	26,31	P-selectin	14,24	CD62P	P-selectin	6403	6403	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of P-selectin -LRB- CD62P -RRB- on platelets after thrombin and ADP in hypotrophic and healthy , full-term newborns .
7531810	0	CD62P	46,51	P-selectin	26,36	CD62P	P-selectin	6403	6403	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated plasma levels of P-selectin -LRB- GMP-140 / CD62P -RRB- in patients with Plasmodium_falciparum malaria .
8683139	0	CD62e	30,35	Heat_shock_protein_65	0,21	CD62e	Heat shock protein 65	6401	3329	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Heat_shock_protein_65 induces CD62e , CD106 , and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes .
21527913	0	CD63	22,26	LMP1	0,4	CD63	LMP1	967	9260	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-kB activation .
24635319	0	CD63	63,67	TIMP-1	0,6	CD63	TIMP-1	967	7076	Gene	Gene	signalling|compound|START_ENTITY stem|nmod|signalling stem|nsubj|chemotaxis chemotaxis|compound|END_ENTITY	TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling .
26001794	0	CD63	21,25	TIMP-1	0,6	CD63	TIMP-1	12512(Tax:10090)	21857(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice .
1634775	0	CD63	50,54	mast_cell_antigen_AD1	8,29	CD63	mast cell antigen AD1	967	29186(Tax:10116)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|dep|homologue	The rat mast_cell_antigen_AD1 -LRB- homologue to human CD63 or melanoma antigen ME491 -RRB- is expressed in other cells in culture .
21838603	0	CD64	73,77	CD14	106,110	CD64	CD14	2209	929	Gene	Gene	START_ENTITY|nmod|CD16 CD16|compound|END_ENTITY	Mesenchymal stromal cells impair the differentiation of CD14 -LRB- + + -RRB- CD16 -LRB- - -RRB- CD64 -LRB- + -RRB- classical monocytes into CD14 -LRB- + + -RRB- CD16 -LRB- + -RRB- CD64 -LRB- + + -RRB- activate monocytes .
8993006	0	CD64	65,69	Fc_gammaRI	53,63	CD64	Fc gammaRI	2209	2209	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Cytolytic and cytostatic properties of an anti-human Fc_gammaRI -LRB- CD64 -RRB- x epidermal growth factor bispecific fusion protein .
10405359	0	CD64	61,65	FcgammaRI	50,59	CD64	FcgammaRI	2209	2209	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of the human high-affinity IgG receptor FcgammaRI -LRB- CD64 -RRB- on residual infectivity of neutralized dengue virus .
10519993	0	CD64	19,23	FcgammaRI	8,17	CD64	FcgammaRI	2209	2209	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of FcgammaRI -LRB- CD64 -RRB- in erythrocyte elimination and its up-regulation in thalassaemia .
16308225	0	CD64	38,42	FcgammaRI	27,36	CD64	FcgammaRI	2209	2209	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cell surface expression of FcgammaRI -LRB- CD64 -RRB- on neutrophils and monocytes in patients with influenza_A , with and without complications .
17905303	0	CD64	49,53	FcgammaRI	38,47	CD64	FcgammaRI	2209	2209	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Simultaneous quantitative analysis of FcgammaRI -LRB- CD64 -RRB- expression on neutrophils and monocytes : a new , improved way to detect infections .
18320015	0	CD64	31,35	FcgammaRI	20,29	CD64	FcgammaRI	2209	2209	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Early expression of FcgammaRI -LRB- CD64 -RRB- on monocytes of cardiac surgical patients and higher density of monocyte anti-inflammatory scavenger CD163 receptor in `` on-pump '' patients .
9613847	0	CD64	40,44	FcgammaRI	29,38	CD64	FcgammaRI	2209	2209	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	High affinity IgG binding by FcgammaRI -LRB- CD64 -RRB- is modulated by two distinct IgSF domains and the transmembrane domain of the receptor .
8258719	0	CD64	46,50	homodimer	87,96	CD64	homodimer	2209	6647	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association of all three types of Fc gamma R -LRB- CD64 , CD32 , and CD16 -RRB- with a gamma-chain homodimer in cultured human monocytes .
1835413	0	CD67	69,73	CD16	86,90	CD67	CD16	1088	2214	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Intracellular localization of glycosyl-phosphatidylinositol-anchored CD67 and FcRIII -LRB- CD16 -RRB- in affected neutrophil granulocytes of patients with paroxysmal_nocturnal_hemoglobinuria .
15361701	0	CD68	0,4	CCR2	15,19	CD68	CCR2	968	729230	Gene	Gene	START_ENTITY|parataxis|reflect reflect|nsubj|expression expression|nummod|END_ENTITY	CD68 and MCP-1 / CCR2 expression of initial biopsies reflect the outcomes of membranous_nephropathy .
23110041	0	CD68	21,25	CCR2	27,31	CD68	CCR2	12514(Tax:10090)	12772(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enrichment of murine CD68 + CCR2 + and CD68 + CD206 + lung macrophages in acute pancreatitis-associated acute_lung_injury .
19730083	0	CD68	14,18	CD123	19,24	CD68	CD123	968	3563	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Plasmacytoid -LRB- CD68 + CD123 + -RRB- monocytes may play a crucial role in the pathogenesis of hydroa vacciniforme : a case report .
21282962	0	CD68	33,37	CD123	39,44	CD68	CD123	968	3563	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|dep|cells cells|compound|+ +|compound|END_ENTITY	Allergen-induced accumulation of CD68 - , CD123 + dendritic cells in the nasal mucosa .
16640542	0	CD68	123,127	CD163	14,19	CD68	CD163	968	9332	Gene	Gene	comparison|nmod|START_ENTITY Expression|dep|comparison Expression|nmod|END_ENTITY	Expression of CD163 in dermatofibroma , cellular fibrous_histiocytoma , and dermatofibrosarcoma_protuberans : comparison with CD68 , CD34 , and Factor_XIIIa .
24515766	0	CD68	42,46	CD163	0,5	CD68	CD163	968	9332	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	CD163 immunohistochemistry is superior to CD68 in predicting outcome in classical_Hodgkin_lymphoma .
25595995	0	CD68	13,17	CD56	28,32	CD68	CD56	968	4684	Gene	Gene	START_ENTITY|dep|- -|compound|END_ENTITY	Intratumoral CD68 - , CD117 - , CD56 - , and CD1a-positive immune cells and the survival of Iranian patients with non-metastatic intestinal-type gastric_carcinoma .
10782809	0	CD68	124,128	tumor_necrosis_factor-alpha	68,95	CD68	tumor necrosis factor-alpha	968	7124	Gene	Gene	cells|compound|START_ENTITY produced|nmod|cells END_ENTITY|acl|produced	Synovial_hyperplasia in HTLV-I associated arthropathy is induced by tumor_necrosis_factor-alpha produced by HTLV-I infected CD68 + cells .
11200053	0	CD69	123,127	5-lipoxygenase	155,169	CD69	5-lipoxygenase	969	240	Gene	Gene	START_ENTITY|nmod|eosinophils eosinophils|nmod|pathway pathway|amod|END_ENTITY	Pivotal role of 5-lipoxygenase in the activation of human eosinophils : platelet-activating_factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway .
11200053	0	CD69	123,127	5-lipoxygenase	16,30	CD69	5-lipoxygenase	969	240	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Pivotal role of 5-lipoxygenase in the activation of human eosinophils : platelet-activating_factor and interleukin-5 induce CD69 on eosinophils through the 5-lipoxygenase pathway .
9580241	0	CD69	53,57	AP-1	99,103	CD69	AP-1	969	3725	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of the leukocyte early activation antigen CD69 is regulated by the transcription factor AP-1 .
12511714	0	CD69	115,119	CD103	121,126	CD69	CD103	969	3682	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Sputum T lymphocytes in asthma , COPD and healthy subjects have the phenotype of activated intraepithelial T cells -LRB- CD69 + CD103 + -RRB- .
10397327	0	CD69	13,17	CD4	36,39	CD69	CD4	969	920	Gene	Gene	antigen|nummod|START_ENTITY antigen|nmod|+ +|compound|END_ENTITY	Induction of CD69 antigen on normal CD4 + and CD8 + lymphocyte subsets and its relationship with the phenotype of responding T-cells .
11328741	0	CD69	0,4	CD4	30,33	CD69	CD4	969	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD69 expression on peripheral CD4 + T cells parallels disease activity and is reduced by mycophenolate_mofetil therapy in uveitis .
12507400	0	CD69	63,67	CD4	31,34	CD69	CD4	969	920	Gene	Gene	expression|compound|START_ENTITY Evaluation|appos|expression Evaluation|nmod|END_ENTITY	Evaluation of peripheral blood CD4 and CD8 lymphocyte subsets , CD69 expression and histologic rejection grade as diagnostic markers for the presence of cardiac allograft rejection .
15642992	0	CD69	0,4	CD4	19,22	CD69	CD4	969	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	CD69 expression on CD4 + T lymphocytes after in vitro stimulation with tuberculin is an indicator of immune sensitization against Mycobacterium_tuberculosis antigens .
16396693	0	CD69	20,24	CD4	49,52	CD69	CD4	969	920	Gene	Gene	effect|nmod|START_ENTITY expression|nsubj|effect expression|nmod|cells cells|compound|END_ENTITY	Prolactin effect on CD69 and CD154 expression by CD4 + cells from systemic_lupus_erythematosus patients .
19109141	0	CD69	0,4	CD4	6,9	CD69	CD4	12515(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	CD69 + CD4 + CD25 - T cells , a new subset of regulatory T cells , suppress T cell proliferation through membrane-bound TGF-beta_1 .
19670272	0	CD69	68,72	CD4	92,95	CD69	CD4	969	920	Gene	Gene	molecules|amod|START_ENTITY molecules|nmod|cell cell|compound|END_ENTITY	AFM - and NSOM-based force spectroscopy and distribution analysis of CD69 molecules on human CD4 + T cell membrane .
20400202	0	CD69	72,76	CD4	36,39	CD69	CD4	12515(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY restores|dobj|expression restores|nsubj|treatment treatment|nmod|cells cells|compound|END_ENTITY	Ex vivo enzymatic treatment of aged CD4 T cells restores antigen-driven CD69 expression and proliferation in mice .
20696642	0	CD69	15,19	CD4	37,40	CD69	CD4	969	920	Gene	Gene	up-regulation|nummod|START_ENTITY up-regulation|nmod|Cla Cla|compound|END_ENTITY	Association of CD69 up-regulation on CD4 + Cla + T cells versus patch test , strip patch test and clinical history in nickel sensitization .
22250092	0	CD69	0,4	CD4	65,68	CD69	CD4	12515(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signals signals|nmod|cells cells|compound|END_ENTITY	CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential .
22252752	0	CD69	99,103	CD4	171,174	CD69	CD4	969	920	Gene	Gene	+|nummod|START_ENTITY expression|nmod|+ expression|appos|markers markers|nmod|+ +|compound|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
22507356	0	CD69	29,33	CD4	18,21	CD69	CD4	969	920	Gene	Gene	T|compound|START_ENTITY frequency|dep|T frequency|nmod|CD25 CD25|compound|END_ENTITY	High frequency of CD4 + CD25 - CD69 + T cells is correlated with a low risk of acute_graft-versus-host_disease in allotransplants .
26869766	0	CD69	127,131	CD4	114,117	CD69	CD4	12515(Tax:10090)	12504(Tax:10090)	Gene	Gene	proliferation|compound|START_ENTITY proliferation|amod|magnesium_isoglycyrrhizinate magnesium_isoglycyrrhizinate|nmod|inhibition inhibition|nmod|CD25 CD25|compound|END_ENTITY	Amelioration of concanavalin A-induced autoimmune_hepatitis by magnesium_isoglycyrrhizinate through inhibition of CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- CD69 -LRB- + -RRB- subset proliferation .
8972737	0	CD69	168,172	CD4	20,23	CD69	CD4	12515(Tax:10090)	12504(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY immunosuppression|dep|analysis CD8|dep|immunosuppression due|nmod|CD8 due|nsubj|Unresponsiveness Unresponsiveness|nmod|cells cells|nummod|END_ENTITY	Unresponsiveness of CD4 + T cells from a non-responder strain to HgCl2 is not due to CD8 -LRB- + -RRB- - mediated immunosuppression : an analysis of the very early activation antigen CD69 .
9605996	0	CD69	73,77	CD4	100,103	CD69	CD4	969	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	A whole-blood assay for qualitative and semiquantitative measurements of CD69 surface expression on CD4 and CD8 T lymphocytes using flow cytometry .
9686587	0	CD69	61,65	CD4	12,15	CD69	CD4	12515(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY cells|dep|expressing cells|compound|END_ENTITY	A subset of CD4 + T cells expressing early activation antigen CD69 in murine lupus : possible abnormal regulatory role for cytokine imbalance .
17973783	0	CD69	0,4	CD56	8,12	CD69	CD56	969	4684	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	CD69 on CD56 + NK cells and response to chemoimmunotherapy in metastatic melanoma .
15319390	0	CD69	49,53	CD56dimCD16	37,48	CD69	CD56dimCD16	969	4684;2214	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	An increase in the absolute count of CD56dimCD16 + CD69 + NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome .
1500624	0	CD69	22,26	CD69	74,78	CD69	CD69	969	969	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	In vivo expression of CD69 on lung eosinophils in eosinophilic_pneumonia : CD69 as a possible activation marker for eosinophils .
1500624	0	CD69	74,78	CD69	22,26	CD69	CD69	969	969	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In vivo expression of CD69 on lung eosinophils in eosinophilic_pneumonia : CD69 as a possible activation marker for eosinophils .
12865808	0	CD69	0,4	CD8	30,33	CD69	CD8	969	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients .
1548145	0	CD69	23,27	CD8	56,59	CD69	CD8	969	925	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|endomyocardium endomyocardium|compound|END_ENTITY	The activation antigen CD69 is selectively expressed on CD8 + endomyocardium infiltrating T lymphocytes in human rejecting heart allografts .
18856207	0	CD69	56,60	CD8	64,67	CD69	CD8	969	925	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Evaluation of the expression of early activation marker CD69 by CD8 + lymphocytes in HIV-infected patients .
24566284	0	CD69	82,86	CD8	61,64	CD69	CD8	969	925	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	Mycobacterium_tuberculosis-specific polyfunctional cytotoxic CD8 + T cells express CD69 .
7697728	0	CD69	70,74	CD8	33,36	CD69	CD8	969	925	Gene	Gene	lack|dobj|START_ENTITY cells|acl:relcl|lack Accumulation|dep|cells Accumulation|nmod|END_ENTITY	Accumulation of immature CD3-CD4 + CD8 - single-positive cells that lack CD69 in epithelial cell tumors of the human thymus .
19109141	0	CD69	0,4	TGF-beta_1	115,125	CD69	TGF-beta 1	12515(Tax:10090)	21803(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|appos|proliferation proliferation|nmod|END_ENTITY	CD69 + CD4 + CD25 - T cells , a new subset of regulatory T cells , suppress T cell proliferation through membrane-bound TGF-beta_1 .
1617156	0	CD69	0,4	interferon-alpha	48,64	CD69	interferon-alpha	969	111654(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CD69 is expressed on Daudi cells in response to interferon-alpha .
1533569	0	CD69	86,90	interleukin_2	42,55	CD69	interleukin 2	969	3558	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Different sensitivity to interleukin_4 of interleukin_2 - and interferon alpha-induced CD69 antigen expression in human resting NK cells and CD3 + , CD4 - , CD8 - lymphocytes .
24727323	0	CD7	48,51	CADM1	0,5	CD7	CADM1	924	23705	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	CADM1 expression and stepwise downregulation of CD7 are closely associated with clonal expansion of HTLV-I-infected cells in adult_t-cell_leukemia / lymphoma .
1375001	0	CD7	94,97	CD1	112,115	CD7	CD1	924	911	Gene	Gene	+|compound|START_ENTITY +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
24441947	0	CD7	49,52	CD15	54,58	CD7	CD15	924	2526	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Normal karyotype acute_myeloid_leukemia with the CD7 + CD15 + CD34 + HLA-DR + immunophenotype is a clinically distinct entity with a favorable outcome .
7686950	0	CD7	20,23	CD19	24,28	CD7	CD19	924	930	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of CD7 + CD19 + lymphoid cells after Epstein-Barr_virus_transformation .
2783659	0	CD7	89,92	CD2	83,86	CD7	CD2	924	914	Gene	Gene	+|compound|START_ENTITY phenotype|appos|+ phenotype|nmod|+ +|compound|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
9379681	0	CD7	84,87	CD2	79,82	CD7	CD2	924	914	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Granulocyte-colony_stimulating_factor induces differentiation and apoptosis of CD2 , CD7 positive hybrid leukemia cells in vivo and ex vivo .
14707048	0	CD7	0,3	CD25	41,45	CD7	CD25	12516(Tax:10090)	16184(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|+ +|compound|END_ENTITY	CD7 and CD28 are required for murine CD4 + CD25 + regulatory T cell homeostasis and prevention of thyroiditis .
10398310	0	CD7	0,3	CD34	18,22	CD7	CD34	924	947	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	CD7 expression on CD34 + cells from chronic_myeloid_leukaemia in chronic phase .
11090056	0	CD7	83,86	CD34	76,80	CD7	CD34	924	947	Gene	Gene	CD45RA|compound|START_ENTITY END_ENTITY|dep|CD45RA	Characterization of dendritic cell differentiation pathways from cord blood CD34 -LRB- + -RRB- CD7 -LRB- + -RRB- CD45RA -LRB- + -RRB- hematopoietic progenitor cells .
12950236	0	CD7	0,3	CD34	18,22	CD7	CD34	924	947	Gene	Gene	START_ENTITY|dep|expression expression|nmod|+ +|compound|END_ENTITY	CD7 expression by CD34 + cells in CML patients , of prognostic significance ?
15701834	0	CD7	5,8	CD34	0,4	CD7	CD34	924	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD34 + CD7 + leukemic progenitor cells may be involved in maintenance and clonal evolution of chronic_myeloid_leukemia .
16144796	0	CD7	64,67	CD34	23,27	CD7	CD34	924	947	Gene	Gene	expression|nmod|START_ENTITY identifies|dobj|expression identifies|nsubj|profiling profiling|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Molecular profiling of CD34 + cells identifies low expression of CD7 , along with high expression of proteinase_3 or elastase , as predictors of longer survival in patients with CML .
17852828	0	CD7	19,22	CD34	26,30	CD7	CD34	924	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|+ +|compound|END_ENTITY	High expression of CD7 on CD34 + cells is not linked to deletion of derivative chromosome 9 or lack of dendritic cells in chronic_myeloid_leukaemia .
24441947	0	CD7	49,52	CD34	60,64	CD7	CD34	924	947	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Normal karyotype acute_myeloid_leukemia with the CD7 + CD15 + CD34 + HLA-DR + immunophenotype is a clinically distinct entity with a favorable outcome .
9220659	0	CD7	86,89	CD34	27,31	CD7	CD34	924	947	Gene	Gene	established|nmod|START_ENTITY line|acl|established myeloid|dobj|line myeloid|nsubj|expressing expressing|compound|END_ENTITY	GM-CSF - and IL-3-dependent CD34 expressing myeloid cell line -LRB- SAS-1 -RRB- established from CD7 and CD34 expressing acute myeloblastic leukemic cells .
9364871	0	CD7	1,4	CD34	7,11	CD7	CD34	924	947	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	-LSB- CD7 + , CD34 + , electronmicroscopically peroxidase-negative acute_leukemia transformed from polycythemia vera after 12 years follow-up -RSB- .
10421055	0	CD7	53,56	CD4	49,52	CD7	CD4	924	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Genotypic , phenotypic and functional analysis of CD4 + CD7 + and CD4 + CD7 - T lymphocyte subsets in S __ zary_syndrome .
10620124	0	CD7	7,10	CD4	0,3	CD7	CD4	924	920	Gene	Gene	T|dep|START_ENTITY T|compound|END_ENTITY	CD4 + / CD7 - T cell frequency and polymerase chain reaction-based clonality assay correlate with stage in cutaneous_T_cell_lymphomas .
11550091	0	CD7	4,7	CD4	21,24	CD7	CD4	924	920	Gene	Gene	subset|compound|START_ENTITY subset|nmod|memory memory|compound|END_ENTITY	The CD7 -LRB- - -RRB- subset of CD4 -LRB- + -RRB- memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 -LRB- IL-15 -RRB- .
12148887	0	CD7	39,42	CD4	31,34	CD7	CD4	924	920	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Spontaneous IL-8 production by CD4 -LRB- + -RRB- , CD7 -LRB- + -RRB- leukemia cells in erythrodermic_S __ zary_syndrome .
12950240	0	CD7	24,27	CD4	19,22	DC2	CD4	116255	920	Gene	Gene	CD56|compound|START_ENTITY CD56|compound|END_ENTITY	An unusual case of CD4 + CD7 + CD56 + acute_leukemia with overlapping features of type 2 dendritic cell -LRB- DC2 -RRB- and myeloid/NK cell precursor acute_leukemia .
1375001	0	CD7	94,97	CD4	100,103	CD7	CD4	924	920	Gene	Gene	+|compound|START_ENTITY +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
14707048	0	CD7	0,3	CD4	37,40	CD7	CD4	12516(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|+ +|compound|END_ENTITY	CD7 and CD28 are required for murine CD4 + CD25 + regulatory T cell homeostasis and prevention of thyroiditis .
17287851	0	CD7	125,128	CD4	28,31	CD7	CD4	924	920	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression results|nmod|loss influx|acl:relcl|results alteration|nmod|influx leads|nmod|alteration leads|nsubj|HTLV-I_infection HTLV-I_infection|nmod|line line|compound|END_ENTITY	HTLV-I_infection of WE17/10 CD4 + cell line leads to progressive alteration of Ca2 + influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation .
21205081	0	CD7	64,67	CD4	90,93	CD7	CD4	924	920	Gene	Gene	enriched|nmod|START_ENTITY enriched|dobj|cells cells|amod|subpopulation subpopulation|nmod|T T|compound|END_ENTITY	Leukemic_T cells are specifically enriched in a unique CD3 -LRB- dim -RRB- CD7 -LRB- low -RRB- subpopulation of CD4 -LRB- + -RRB- T cells in acute-type adult_T-cell_leukemia .
2783659	0	CD7	89,92	CD4	110,113	CD7	CD4	924	920	Gene	Gene	+|compound|START_ENTITY phenotype|appos|+ lymphoma|nmod|phenotype lymphoma|appos|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
2783859	0	CD7	0,3	CD4	6,9	CD7	CD4	924	920	Gene	Gene	+|compound|START_ENTITY +|appos|- -|compound|END_ENTITY	CD7 + , CD4 - , CD8 - acute leukemia : a syndrome of malignant pluripotent lymphohematopoietic cells .
8973627	0	CD7	4,7	CD4	78,81	CD7	CD4	924	920	Gene	Gene	START_ENTITY|dep|represents represents|nmod|CD45RA CD45RA|compound|END_ENTITY	The CD7 - T cell subset represents the majority of IL-5-secreting cells within CD4 + CD45RA - T cells .
1709216	0	CD7	7,10	CD5	1,4	CD7	CD5	924	921	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	-LSB- CD5 + , CD7 + , and CD19 + non-Hodgkin 's _ lymphoma in a child -RSB- .
24617050	0	CD7	44,47	CD5	40,43	CD7	CD5	924	921	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	P-glycoprotein-1 functional activity in CD5 + CD7 + and CD20 + lymphocytes in systemic_lupus_erythematosus children : relation to disease activity , complications and steroid response .
2783659	0	CD7	89,92	CD5	97,100	CD7	CD5	924	921	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Poor prognosis of mediastinal non-Hodgkin 's _ lymphoma with an immature phenotype of CD2 + , CD7 -LRB- or CD5 -RRB- + , CD3 - , CD4 - , and CD8 - .
7513945	0	CD7	44,47	CD5	49,52	CD7	CD5	924	921	Gene	Gene	CD2|compound|START_ENTITY CD2|compound|END_ENTITY	Lineage determination of CD7 + CD5 - CD2 - and CD7 + CD5 + CD2 - lymphoblasts : studies on phenotype , genotype , and gene expression of myeloperoxidase , CD3_epsilon , and CD3_delta .
10435360	0	CD7	5,8	CD56	0,4	CD7	CD56	924	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD56 + CD7 + stem cell leukemia/lymphoma with D2-Jdelta1 rearrangement .
20111912	0	CD7	32,35	CD56	37,41	CD7	CD56	924	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The clinical characteristics of CD7 + CD56 + acute_myeloid_leukemias other than M0 .
12594257	0	CD7	0,3	CD8	57,60	CD7	CD8	924	925	Gene	Gene	marker|nsubj|START_ENTITY marker|acl:relcl|identifies identifies|dobj|subsets subsets|compound|END_ENTITY	CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets .
1375001	0	CD7	94,97	CD8	106,109	CD7	CD8	924	925	Gene	Gene	+|compound|START_ENTITY +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
15308569	0	CD7	13,16	CD8	40,43	CD7	CD8	924	925	Gene	Gene	Expansion|nmod|START_ENTITY END_ENTITY|nsubj|Expansion	Expansion of CD7 -LRB- low -RRB- and CD7 -LRB- negative -RRB- CD8 T-cell effector subsets in HIV-1_infection : correlation with antigenic load and reversion by antiretroviral treatment .
1696925	0	CD7	132,135	CD8	57,60	CD7	CD8	924	925	Gene	Gene	F1|nummod|START_ENTITY expression|nmod|F1 gastric_T-cell_lymphoma|dep|expression gastric_T-cell_lymphoma|nmod|phenotype phenotype|appos|+ +|compound|END_ENTITY	Primary gastric_T-cell_lymphoma of suppressor-cytotoxic -LRB- CD8 + -RRB- phenotype : discordant expression of T-cell receptor subunit beta F1 , CD7 , and CD3 antigens .
2783859	0	CD7	0,3	CD8	12,15	CD7	CD8	924	925	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	CD7 + , CD4 - , CD8 - acute leukemia : a syndrome of malignant pluripotent lymphohematopoietic cells .
26308138	0	CD7	31,34	MLL	11,14	CD7	MLL	924	4297	Gene	Gene	CD56|compound|START_ENTITY CD56|compound|END_ENTITY	Aggressive MLL gene rearranged CD7 + CD56 + myeloid/natural killer cell precursor acute leukaemia with extramedullary relapse in the uterus and breast .
1712681	0	CD7	79,82	RFT2	65,69	CD7	RFT2	924	113278	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of lymphocyte proliferation by a monoclonal antibody -LRB- RFT2 -RRB- against CD7 .
19937140	0	CD7	17,20	Twist2	0,6	CD7	Twist2	924	117581	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells .
1709867	0	CD7	22,25	gp40	27,31	CD7	gp40	924	924	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Direct involvement of CD7 -LRB- gp40 -RRB- in activation of TcR gamma/delta + T cells .
23911852	0	CD70	137,141	CD19	117,121	CD70	CD19	970	930	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
23911852	0	CD70	137,141	CD20	124,128	CD70	CD20	970	54474	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
17615291	0	CD70	0,4	CD25	103,107	CD70	CD25	21948(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|induce induce|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
12100033	0	CD70	26,30	CD27	50,54	CD70	CD27	970	939	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|cells cells|amod|naive naive|dep|END_ENTITY	Impaired up-regulation of CD70 and CD86 in naive -LRB- CD27 - -RRB- B cells from patients with common_variable_immunodeficiency -LRB- CVID -RRB- .
12496380	0	CD70	37,41	CD27	25,29	CD70	CD27	21948(Tax:10090)	21940(Tax:10090)	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the murine CD27 ligand CD70 in vitro and in vivo .
23206232	0	CD70	14,18	CD27	143,147	CD70	CD27	970	939	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|proliferation proliferation|nmod|END_ENTITY	Expression of CD70 in nasal natural killer/T _ cell_lymphoma cell lines and patients ; its role for cell proliferation through binding to soluble CD27 .
23911852	0	CD70	137,141	CD27	144,148	CD70	CD27	970	939	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
23913967	0	CD70	0,4	CD27	42,46	CD70	CD27	21948(Tax:10090)	21940(Tax:10090)	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|END_ENTITY	CD70 is downregulated by interaction with CD27 .
24211844	0	CD70	29,33	CD27	0,4	CD70	CD27	970	939	Gene	Gene	protein|compound|START_ENTITY engagement|nmod|protein engagement|nummod|END_ENTITY	CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56bright natural killer cells by IFN-y secretion .
25691774	0	CD70	19,23	CD27	126,130	CD70	CD27	970	939	Gene	Gene	Expression|compound|START_ENTITY Associated|nsubj|Expression Associated|nmod|Infiltration Infiltration|nmod|Lymphocytes Lymphocytes|nmod|END_ENTITY	pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27 + Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear_Cell_Renal_Cell_Carcinoma .
25691774	0	CD70	19,23	CD27	70,74	CD70	CD27	970	939	Gene	Gene	Expression|compound|START_ENTITY Associated|nsubj|Expression Associated|nmod|Infiltration Infiltration|nmod|Lymphocytes Lymphocytes|compound|END_ENTITY	pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27 + Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear_Cell_Renal_Cell_Carcinoma .
7540066	0	CD70	35,39	CD27	14,18	CD70	CD27	970	939	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD27 and its ligand , CD70 , on chronic_lymphocytic_leukemia B cells .
8186199	0	CD70	0,4	CD27	37,41	CD70	CD27	970	939	Gene	Gene	represents|nsubj|START_ENTITY represents|dobj|ligand ligand|nmod|END_ENTITY	CD70 represents the human ligand for CD27 .
8977292	0	CD70	51,55	CD27	57,61	CD70	CD27	970	939	Gene	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Phenotype and function of human B cells expressing CD70 -LRB- CD27 ligand -RRB- .
9366422	0	CD70	27,31	CD27	78,82	CD70	CD27	21948(Tax:10090)	21940(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|ligand ligand|nmod|END_ENTITY	Characterization of murine CD70 , the ligand of the TNF receptor family member CD27 .
16920932	0	CD70	16,20	CD4	24,27	CD70	CD4	21948(Tax:10090)	12504(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|nmod|cell-dependent cell-dependent|compound|END_ENTITY	Requirement for CD70 in CD4 + Th cell-dependent and innate receptor-mediated CD8 + T cell priming .
17615291	0	CD70	0,4	CD4	99,102	CD70	CD4	21948(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|induce induce|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
19952354	0	CD70	0,4	CD4	100,103	CD70	CD4	21948(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY plays|nsubj|expression plays|dobj|role role|nmod|immunogenicity immunogenicity|nmod|CD40-independent CD40-independent|appos|T T|compound|END_ENTITY	CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent , CD4 + T cell-dependent , licensed CD8 + T cell responses .
20201989	0	CD70	103,107	CD4	117,120	CD70	CD4	970	920	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|T-cell T-cell|compound|END_ENTITY	Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4 -LRB- + -RRB- T-cell differentiation .
20201989	0	CD70	24,28	CD4	117,120	CD70	CD4	970	920	Gene	Gene	induction|compound|START_ENTITY stimulation|nmod|induction stimulation|nmod|T-cell T-cell|compound|END_ENTITY	Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4 -LRB- + -RRB- T-cell differentiation .
20223637	0	CD70	58,62	CD4	124,127	CD70	CD4	970	920	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Epigenetics and SLE : RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4 + T cells .
20724115	0	CD70	38,42	CD4	55,58	CD70	CD4	970	920	Gene	Gene	Hypomethylation|nmod|START_ENTITY Hypomethylation|nmod|cells cells|nummod|END_ENTITY	Hypomethylation and overexpression of CD70 -LRB- TNFSF7 -RRB- in CD4 + T cells of patients with primary Sj gren 's syndrome .
26462636	0	CD70	39,43	CD4	47,50	CD70	CD4	970	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	-LSB- Hypomethylation and overexpression of CD70 in CD4 + T cells of the patients with immuno-related pancytopenia -RSB- .
25062112	0	CD70	24,28	CD40	125,129	CD70	CD40	970	958	Gene	Gene	START_ENTITY|nmod|Stimulation Stimulation|compound|END_ENTITY	Significantly Increased CD70 Up Regulation on TEL-AML Positive B Cell Precursor Acute Lymphoblastic_Leukemia Cells Following CD40 Stimulation .
9622100	0	CD70	51,55	CD40	80,84	CD70	CD40	21948(Tax:10090)	21939(Tax:10090)	Gene	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Enhancement of antitumor immunity by expression of CD70 -LRB- CD27_ligand -RRB- or CD154 -LRB- CD40 ligand -RRB- costimulatory molecules in tumor cells .
23911852	0	CD70	137,141	CD43	157,161	CD70	CD43	970	6693	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19 CD20 CD3 CD70 CD27 IgM CD43 CD5 / .
19029446	0	CD70	96,100	OX40L	89,94	CD70	OX40L	970	7292	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Prostaglandin_E -LRB- 2 -RRB- enhances T-cell proliferation by inducing the costimulatory molecules OX40L , CD70 , and 4-1BBL on dendritic cells .
21192791	0	CD70	15,19	RFX1	0,4	CD70	RFX1	970	5989	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RFX1 regulates CD70 and CD11a expression in lupus_T cells by recruiting the histone methyltransferase SUV39H1 .
24569779	0	CD70	18,22	TGF-b	0,5	CD70	TGF-b	970	7040	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TGF-b upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell_non-Hodgkin 's _ lymphoma .
21490618	0	CD70	0,4	Th1	33,36	CD70	Th1	970	51497	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses .
22252752	0	CD71	106,110	CD26	132,136	CD71	CD26	7037	1803	Gene	Gene	+|compound|START_ENTITY expression|appos|+ expression|appos|+ +|compound|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
9632270	0	CD71	31,35	CD34	25,29	CD71	CD34	7037	947	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Bone marrow steady-state CD34 + / CD71 - cell content is a predictive value of rG-CSF-mobilized CD34 + cells .
9632270	0	CD71	31,35	CD34	92,96	CD71	CD34	7037	947	Gene	Gene	+|dep|START_ENTITY value|nsubj|+ value|nmod|cells cells|compound|END_ENTITY	Bone marrow steady-state CD34 + / CD71 - cell content is a predictive value of rG-CSF-mobilized CD34 + cells .
22252752	0	CD71	106,110	CD4	171,174	CD71	CD4	7037	920	Gene	Gene	+|compound|START_ENTITY expression|appos|+ expression|appos|markers markers|nmod|+ +|compound|END_ENTITY	The role of tumor cells in the modification of T lymphocytes activity -- the expression of the early CD69 + , CD71 + and the late CD25 + , CD26 + , HLA/DR + activation markers on T CD4 + and CD8 + cells in squamous_cell_laryngeal_carcinoma .
12538733	0	CD71	127,131	CD71	27,31	CD71	CD71	7037	7037	Gene	Gene	expression|compound|START_ENTITY association|nmod|expression expression|dep|association expression|nmod|receptor receptor|compound|END_ENTITY	Enhanced expression of the CD71 mesangial IgA1 receptor in Berger_disease and Henoch-Sch nlein nephritis : association between CD71 expression and IgA deposits .
12538733	0	CD71	27,31	CD71	127,131	CD71	CD71	7037	7037	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|dep|association association|nmod|expression expression|compound|END_ENTITY	Enhanced expression of the CD71 mesangial IgA1 receptor in Berger_disease and Henoch-Sch nlein nephritis : association between CD71 expression and IgA deposits .
8255102	0	CD71	50,54	CD8	39,42	CD71	CD8	7037	925	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Soluble CD23 and other receptors -LRB- CD4 , CD8 , CD25 , CD71 -RRB- in serum of patients with chronic_lymphocytic_leukemia .
12538733	0	CD71	127,131	IgA1	42,46	CD71	IgA1	7037	3493	Gene	Gene	expression|compound|START_ENTITY association|nmod|expression expression|dep|association expression|nmod|receptor receptor|compound|END_ENTITY	Enhanced expression of the CD71 mesangial IgA1 receptor in Berger_disease and Henoch-Sch nlein nephritis : association between CD71 expression and IgA deposits .
12538733	0	CD71	27,31	IgA1	42,46	CD71	IgA1	7037	3493	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Enhanced expression of the CD71 mesangial IgA1 receptor in Berger_disease and Henoch-Sch nlein nephritis : association between CD71 expression and IgA deposits .
7770514	0	CD71	34,38	transferrin_receptor	12,32	CD71	transferrin receptor	7037	7037	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of transferrin_receptor -LRB- CD71 -RRB- in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic_acid -LRB- ALA -RRB- .
1384316	0	CD72	20,24	Lyb-2	6,11	CD72	Lyb-2	971	971	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	Human Lyb-2 homolog CD72 is a marker for progenitor B-cell_leukemias .
7876545	0	CD72	23,27	Lyb-2	29,34	CD72	Lyb-2	12517(Tax:10090)	12517(Tax:10090)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Structure of the mouse CD72 -LRB- Lyb-2 -RRB- gene and its alternatively spliced transcripts .
9590210	0	CD72	27,31	SHP-1	66,71	CD72	SHP-1	971	5777	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation .
23749427	0	CD73	0,4	CD25	60,64	CD73	CD25	4907	3559	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|vesicles vesicles|acl|derived derived|nmod|cells cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
24749746	0	CD73	105,109	CD39	11,15	CD73	CD39	4907	953	Gene	Gene	+|compound|START_ENTITY exosomes|nummod|+ produce|nmod|exosomes produce|nsubj|cells cells|compound|END_ENTITY	Human CD4 + CD39 + regulatory T cells produce adenosine upon co-expression of surface CD73_or contact with CD73 + exosomes or CD73 + cells .
25127858	0	CD73	46,50	CD39	41,45	CD73	CD39	4907	953	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Role of TGF-b signaling in generation of CD39 + CD73 + myeloid cells in tumors .
17082591	0	CD73	56,60	CD4	36,39	CD73	CD4	23959(Tax:10090)	12504(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	T regulatory and primed uncommitted CD4 T cells express CD73 , which suppresses effector CD4 T cells by converting 5 ' - adenosine_monophosphate to adenosine .
17082591	0	CD73	56,60	CD4	88,91	CD73	CD4	23959(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|suppresses suppresses|dobj|cells cells|compound|END_ENTITY	T regulatory and primed uncommitted CD4 T cells express CD73 , which suppresses effector CD4 T cells by converting 5 ' - adenosine_monophosphate to adenosine .
21092450	0	CD73	19,23	CD4	27,30	CD73	CD4	4907	920	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression -LSB-|nmod|cells cells|nummod|END_ENTITY	-LSB- The expression of CD73 in CD4 + regulatory T cells in patients with new-onset systemic_lupus_erythematosus -RSB- .
23749427	0	CD73	0,4	CD4	55,58	CD73	CD4	4907	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|vesicles vesicles|acl|derived derived|nmod|cells cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
24005375	0	CD73	6,10	CD4	0,3	CD73	CD4	4907	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 CD73 T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1_infection regardless of viral suppression .
24749746	0	CD73	105,109	CD4	6,9	CD73	CD4	4907	920	Gene	Gene	+|compound|START_ENTITY exosomes|nummod|+ produce|nmod|exosomes produce|nsubj|cells cells|compound|END_ENTITY	Human CD4 + CD39 + regulatory T cells produce adenosine upon co-expression of surface CD73_or contact with CD73 + exosomes or CD73 + cells .
25048464	0	CD73	25,29	CD44	31,35	CD73	CD44	23959(Tax:10090)	12505(Tax:10090)	Gene	Gene	marrow|compound|START_ENTITY marrow|compound|END_ENTITY	BMP-non-responsive Sca1 + CD73 + CD44 + mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation .
25268239	0	CD73	36,40	CD44	41,45	CD73	CD44	23959(Tax:10090)	12505(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Correction : BMP-Non-Responsive Sca1 + CD73 + CD44 + Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation .
23709688	0	CD73	23,27	CD8	28,31	CD73	CD8	4907	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased frequency of CD73 + CD8 + T cells of HIV-infected patients correlates with immune activation and T cell exhaustion .
24357632	0	CD73	77,81	CD8	124,127	CD73	CD8	4907	925	Gene	Gene	cells|compound|START_ENTITY cells|acl|involved involved|nmod|response response|compound|END_ENTITY	HIV `` elite controllers '' are characterized by a high frequency of memory CD8 + CD73 + T cells involved in the antigen-specific CD8 + T-cell response .
24357632	0	CD73	77,81	CD8	72,75	CD73	CD8	4907	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	HIV `` elite controllers '' are characterized by a high frequency of memory CD8 + CD73 + T cells involved in the antigen-specific CD8 + T-cell response .
25490556	0	CD73	0,4	CD8	55,58	CD73	CD8	4907	925	Gene	Gene	Dispensable|nsubj|START_ENTITY Dispensable|nmod|Regulation Regulation|nmod|T-Cells T-Cells|compound|END_ENTITY	CD73 Is Dispensable for the Regulation of Inflationary CD8 + T-Cells after Murine_Cytomegalovirus_Infection and Adenovirus Immunisation .
7691935	0	CD73	35,39	CD8	83,86	CD73	CD8	4907	925	Gene	Gene	molecule|compound|START_ENTITY delivered|nmod|molecule signal|acl|delivered lymphocytes|nsubj|signal lymphocytes|nsubj|T T|compound|END_ENTITY	Co-stimulatory signal delivered by CD73 molecule to human CD45RAhiCD45ROlo -LRB- naive -RRB- CD8 + T lymphocytes .
9280142	0	CD73	24,28	CD8	59,62	CD73	CD8	4907	925	Gene	Gene	START_ENTITY|nmod|subset subset|compound|END_ENTITY	Decreased expression of CD73 -LRB- ecto-5 ' - nucleotidase -RRB- in the CD8 + subset is associated with zinc_deficiency in human patients .
23749427	0	CD73	0,4	Foxp3	66,71	CD73	Foxp3	4907	50943	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|vesicles vesicles|acl|derived derived|nmod|cells cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
17911479	0	CD73	95,99	IFN-beta	23,31	CD73	IFN-beta	4907	3456	Gene	Gene	reference|nmod|START_ENTITY Mechanism|dep|reference Mechanism|nmod|action action|nmod|END_ENTITY	Mechanism of action of IFN-beta in the treatment of multiple_sclerosis : a special reference to CD73 and adenosine .
18034430	0	CD73	61,65	IFN-beta	0,8	CD73	IFN-beta	23959(Tax:10090)	15977(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY leakage|nmod|up-regulation protects|nmod|leakage protects|nsubj|END_ENTITY	IFN-beta protects from vascular leakage via up-regulation of CD73 .
18825744	0	CD73	19,23	IFN-beta	0,8	CD73	IFN-beta	4907	3456	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier .
20476579	0	CD73	30,34	PKC	9,12	CD73	PKC	4907	112476	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	-LSB- Role of PKC in regulation of CD73 by lysophosphatidylcholine in human endothelial cells -RSB- .
25048464	0	CD73	25,29	Sca1	19,23	CD73	Sca1	23959(Tax:10090)	110454(Tax:10090)	Gene	Gene	marrow|compound|START_ENTITY derived|nsubj|marrow +|ccomp|derived +|nsubj|END_ENTITY	BMP-non-responsive Sca1 + CD73 + CD44 + mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation .
25268239	0	CD73	36,40	Sca1	31,35	CD73	Sca1	23959(Tax:10090)	110454(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Correction : BMP-Non-Responsive Sca1 + CD73 + CD44 + Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation .
23086814	0	CD73	31,35	epidermal_growth_factor_receptor	46,78	CD73	epidermal growth factor receptor	4907	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Potential prognostic biomarker CD73 regulates epidermal_growth_factor_receptor expression in human breast_cancer .
26251265	0	CD73	111,115	transforming_growth_factor-b	35,63	CD73	transforming growth factor-b	4907	7040	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	1a,25-dihydroxyvitamin _ D3 acts via transforming_growth_factor-b to up-regulate expression of immunosuppressive CD73 on human CD4 -LRB- + -RRB- Foxp3 -LRB- - -RRB- T cells .
19849849	0	CD74	0,4	APP	20,23	CD74	APP	972	351	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD74 interacts with APP and suppresses the production of Abeta .
25172501	0	CD74	62,66	CXCR2	67,72	CD74	CXCR2	972	3579	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Macrophage_migration_inhibitory_factor triggers chemotaxis of CD74 + CXCR2 + NKT cells in chemically induced IFN-y-mediated skin_inflammation .
18842989	0	CD74	17,21	MIF	4,7	CD74	MIF	972	4282	Gene	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	The MIF receptor CD74 in diabetic_podocyte_injury .
23044992	0	CD74	12,16	MIF	29,32	CD74	MIF	16149(Tax:10090)	17319(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Deletion of CD74 , a putative MIF receptor , in mice enhances osteoclastogenesis and decreases bone mass .
18003616	0	CD74	39,43	Nitric-oxide_synthase_2	0,23	CD74	Nitric-oxide synthase 2	972	4843	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nitric-oxide_synthase_2 interacts with CD74 and inhibits its cleavage by caspase during dendritic cell development .
7997248	0	CD74	45,49	Retinoblastoma	0,14	CD74	Retinoblastoma	972	5925	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Retinoblastoma protein regulation of surface CD74 -LRB- invariant chain -RRB- expression in breast_carcinoma cells .
17959659	0	CD74	63,67	Vpu	36,39	CD74	Vpu	972	155945(Tax:11676)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation .
17142775	0	CD74	70,74	macrophage_migration_inhibitory_factor	14,52	CD74	macrophage migration inhibitory factor	972	4282	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of macrophage_migration_inhibitory_factor or its receptor -LRB- CD74 -RRB- attenuates growth and invasion of DU-145_prostate_cancer cells .
19131591	0	CD74	14,18	macrophage_migration_inhibitory_factor	37,75	CD74	macrophage migration inhibitory factor	972	4282	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|receptor receptor|nmod|END_ENTITY	Expression of CD74 , the receptor for macrophage_migration_inhibitory_factor , in non-small cell lung_cancer .
19325914	0	CD74	49,53	macrophage_migration_inhibitory_factor	68,106	CD74	macrophage migration inhibitory factor	25599(Tax:10116)	103694877	Gene	Gene	START_ENTITY|dep|receptor receptor|nmod|END_ENTITY	Substance P increases cell-surface expression of CD74 -LRB- receptor for macrophage_migration_inhibitory_factor -RRB- : in vivo biotinylation of urothelial cell-surface proteins .
24939415	0	CD74	72,76	macrophage_migration_inhibitory_factor	15,53	CD74	macrophage migration inhibitory factor	972	4282	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of macrophage_migration_inhibitory_factor and its receptor -LRB- CD74 -RRB- in human breast_cancer .
7520411	0	CD79a	42,47	mb-1	36,40	CD79a	mb-1	973	973	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of the B-cell marker mb-1 -LRB- CD79a -RRB- in Hodgkin 's _ disease .
10552962	0	CD79b	37,42	B29	32,35	CD79b	B29	974	974	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of the B-cell receptor B29 -LRB- CD79b -RRB- gene in familial chronic_lymphocytic_leukemia .
7913081	0	CD79b	35,40	B29	50,53	CD79b	B29	974	974	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The complete sequence of the human CD79b -LRB- Ig_beta / B29 -RRB- gene : identification of a conserved exon/intron organization , immunoglobulin-like regulatory regions , and allelic polymorphism .
9269755	0	CD79b	40,45	B29	35,38	CD79b	B29	974	974	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Aberrations of the B-cell receptor B29 -LRB- CD79b -RRB- gene in chronic_lymphocytic_leukemia .
10753858	0	CD79b	23,28	Ig-beta	14,21	CD79b	Ig-beta	974	974	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Ig-beta -LRB- CD79b -RRB- by chronic_lymphocytic_leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion .
11522228	0	CD8	67,70	4-1BB	25,30	CD8	4-1BB	925	3604	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Therapeutic potential of 4-1BB -LRB- CD137 -RRB- as a regulator for effector CD8 -LRB- + -RRB- T cells .
12356681	0	CD8	115,118	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	T|compound|START_ENTITY proliferation|nmod|T augmenting|dobj|proliferation priming|advcl|augmenting cell|acl|priming CD8|dep|cell enhances|nsubj|CD8 enhances|dep|co-stimulation co-stimulation|nmod:npmod|END_ENTITY	4-1BB co-stimulation enhances human CD8 -LRB- + -RRB- T cell priming by augmenting the proliferation and survival of effector CD8 -LRB- + -RRB- T cells .
12356681	0	CD8	36,39	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dep|co-stimulation co-stimulation|nmod:npmod|END_ENTITY	4-1BB co-stimulation enhances human CD8 -LRB- + -RRB- T cell priming by augmenting the proliferation and survival of effector CD8 -LRB- + -RRB- T cells .
12391199	0	CD8	31,34	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	lymphocytes|compound|START_ENTITY survival|nmod|lymphocytes promotes|dobj|survival promotes|nsubj|END_ENTITY	4-1BB promotes the survival of CD8 + T lymphocytes by increasing expression of Bcl-xL and Bfl-1 .
12695569	0	CD8	9,12	4-1BB	55,60	CD8	4-1BB	925	3604	Gene	Gene	cells|compound|START_ENTITY possess|nsubj|cells possess|nmod|END_ENTITY	Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering .
12884287	0	CD8	15,18	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	expansion|compound|START_ENTITY enhances|dobj|expansion enhances|nsubj|END_ENTITY	4-1BB enhances CD8 + T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1 .
15270726	0	CD8	35,38	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	responses|compound|START_ENTITY enhance|dobj|responses enhance|nsubj|END_ENTITY	4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime , poxvirus boost vaccine .
16488622	0	CD8	56,59	4-1BB	17,22	CD8	4-1BB	925	3604	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	Cross-linking of 4-1BB up-regulates IL-13 expression in CD8 -LRB- + -RRB- T lymphocytes .
16524567	0	CD8	44,47	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	responses|compound|START_ENTITY enhances|dobj|responses enhances|nsubj|costimulation costimulation|nummod|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
16524567	0	CD8	92,95	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells enhances|nmod|induction enhances|nsubj|costimulation costimulation|nummod|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
17878391	0	CD8	55,58	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ generating|dobj|lymphocytes CD28|advcl|generating superior|xcomp|CD28 superior|nsubj|END_ENTITY	4-1BB is superior to CD28 costimulation for generating CD8 + cytotoxic lymphocytes for adoptive immunotherapy .
18024793	0	CD8	56,59	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells regulates|dobj|costimulation regulates|nsubj|END_ENTITY	4-1BB regulates NKG2D costimulation in human cord blood CD8 + T cells .
20722077	0	CD8	75,78	4-1BB	17,22	CD8	4-1BB	925	3604	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8 -LRB- + -RRB- T cells .
21742975	0	CD8	78,81	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	responses|compound|START_ENTITY augment|dobj|responses ligand|advcl|augment ligand|nsubj|synergizes synergizes|nummod|END_ENTITY	4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral_infection .
22037570	0	CD8	80,83	4-1BB	21,26	CD8	4-1BB	925	3604	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells role|nmod|END_ENTITY	Dispensable role for 4-1BB and 4-1BBL in development of vaccinia_virus-specific CD8 T cells .
23162550	0	CD8	35,38	4-1BB	10,15	CD8	4-1BB	925	3604	Gene	Gene	responses|compound|START_ENTITY enhance|dobj|responses Targeting|advcl|enhance Targeting|dobj|END_ENTITY	Targeting 4-1BB -LRB- CD137 -RRB- to enhance CD8 T cell responses with poxviruses and viral antigens .
23560068	0	CD8	74,77	4-1BB	23,28	CD8	4-1BB	925	3604	Gene	Gene	expansion|nmod|START_ENTITY improves|dobj|expansion Co-stimulation|parataxis|improves Co-stimulation|nmod|END_ENTITY	Co-stimulation through 4-1BB / CD137 improves the expansion and function of CD8 -LRB- + -RRB- melanoma_tumor-infiltrating lymphocytes for adoptive T-cell therapy .
25962156	0	CD8	71,74	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	T|compound|START_ENTITY Primary|nmod|T Primary|nummod|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
26972770	0	CD8	71,74	4-1BB	0,5	CD8	4-1BB	925	3604	Gene	Gene	+|compound|START_ENTITY enhance|dobj|+ signaling|advcl|enhance END_ENTITY|acl|signaling	4-1BB signaling activates glucose and fatty_acid metabolism to enhance CD8 -LRB- + -RRB- T cell proliferation .
17245353	0	CD8	33,36	AAV	13,16	CD8	AAV	925	17	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Pre-existing AAV capsid-specific CD8 + T cells are unable to eliminate AAV-transduced hepatocytes .
19995901	0	CD8	53,56	APCs	29,33	CD8	APCs	925	325	Gene	Gene	cells|compound|START_ENTITY inactivates|dobj|cells inactivates|nsubj|antigen antigen|nmod|END_ENTITY	Targeting antigen to diverse APCs inactivates memory CD8 + T cells without eliciting tissue-destructive effector function .
22174448	0	CD8	87,90	APCs	77,81	CD8	APCs	925	325	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Antigen-specific transfer of functional programmed_death_ligand_1 from human APCs onto CD8 + T cells via trogocytosis .
17343788	0	CD8	37,40	Akt	30,33	CD8	Akt	925	207	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	-LSB- Promotion of the activity of Akt in CD8 + T cells by the crosslink of 3H3 , an agonist antibody of 4-1BB -RSB- .
17548608	0	CD8	57,60	Akt	109,112	CD8	Akt	925	207	Gene	Gene	CD28-CD27|compound|START_ENTITY loss|nmod|CD28-CD27 loss|parataxis|associated associated|nmod|phosphorylation phosphorylation|compound|END_ENTITY	The loss of telomerase activity in highly differentiated CD8 + CD28-CD27 - T cells is associated with decreased Akt -LRB- Ser473 -RRB- phosphorylation .
19406987	0	CD8	118,121	Akt	34,37	CD8	Akt	925	207	Gene	Gene	cells|compound|START_ENTITY phosphorylation|nmod|cells phosphorylation|amod|END_ENTITY	KLRG1 signaling induces defective Akt -LRB- ser473 -RRB- phosphorylation and proliferative dysfunction of highly differentiated CD8 + T cells .
22467649	0	CD8	36,39	Akt	22,25	CD8	Akt	925	207	Gene	Gene	effector|compound|START_ENTITY effector|compound|END_ENTITY	Signal integration by Akt regulates CD8 T cell effector and memory differentiation .
21033101	0	CD8	34,37	BCL-2	21,26	CD8	BCL-2	925	596	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
16932347	0	CD8	65,68	BCR-ABL	0,7	CD8	BCR-ABL	925	25	Gene	Gene	T-cell|compound|START_ENTITY source|nmod|T-cell regions|nmod|source regions|amod|END_ENTITY	BCR-ABL fusion regions as a source of multiple_leukemia-specific CD8 + T-cell epitopes .
12515721	0	CD8	20,23	BV8	25,28	CD8	BV8	925	60675	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Clonal expansion of CD8 + BV8 T lymphocytes in bone marrow characterizes thymoma-associated B_lymphopenia .
10754284	0	CD8	71,74	Bcl-2	38,43	CD8	Bcl-2	925	596	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Cutting edge : increased expression of Bcl-2 in antigen-specific memory CD8 + T cells .
11568004	0	CD8	109,112	Bcl-2	164,169	CD8	Bcl-2	925	596	Gene	Gene	persistence|nmod|START_ENTITY Interleukin-7|nmod|persistence thymocytes|dep|Interleukin-7 thymocytes|nmod|induction induction|nmod|END_ENTITY	Interleukin-7 and infection itself by human_immunodeficiency_virus_1 favor virus persistence in mature CD4 -LRB- + -RRB- CD8 -LRB- - -RRB- CD3 -LRB- + -RRB- thymocytes through sustained induction of Bcl-2 .
15034060	0	CD8	13,16	Bcl-2	61,66	CD8	Bcl-2	925	596	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|exhibit exhibit|dobj|levels levels|nmod|END_ENTITY	HIV-specific CD8 + T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL .
17090688	0	CD8	106,109	Bcl-2	14,19	CD8	Bcl-2	925	596	Gene	Gene	line|compound|START_ENTITY differentiation|nmod|line critical|nmod|differentiation critical|nsubj|induction induction|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
21451108	0	CD8	33,36	Bcl-2	0,5	CD8	Bcl-2	925	596	Gene	Gene	cells|nummod|START_ENTITY allows|dobj|cells allows|nsubj|END_ENTITY	Bcl-2 allows effector and memory CD8 + T cells to tolerate higher expression of Bim .
24364474	0	CD8	64,67	Bcl-2	44,49	CD8	Bcl-2	925	596	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Impact of treatment with methimazole on the Bcl-2 expression in CD8 + peripheral blood lymphocytes in children with Graves ' _ disease .
7541577	0	CD8	84,87	Bcl-2	48,53	CD8	Bcl-2	925	596	Gene	Gene	lymphocytosis|nummod|START_ENTITY Implication|nmod|lymphocytosis Implication|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Implication of cyclosporine in up-regulation of Bcl-2 expression and maintenance of CD8 lymphocytosis in cytomegalovirus-infected allograft recipients .
8690919	0	CD8	107,110	Bcl-2	53,58	CD8	Bcl-2	925	596	Gene	Gene	T|compound|START_ENTITY associated|nmod|T associated|nmod|down-regulation down-regulation|nmod|END_ENTITY	Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8 + T lymphocytes during HIV_infection .
22745171	0	CD8	85,88	Blimp-1	70,77	CD8	Blimp-1	925	639	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8 + T cell .
24590765	0	CD8	18,21	Blimp-1	0,7	CD8	Blimp-1	925	639	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral_infection .
19144272	0	CD8	19,22	CCL16	0,5	CD8	CCL16	925	6360	Gene	Gene	+|compound|START_ENTITY enhances|dobj|+ enhances|nsubj|END_ENTITY	CCL16 enhances the CD8 + and CD4 + T cell reactivity to human HER-2 elicited by dendritic cells loaded with rat ortholog HER-2 .
10940868	0	CD8	16,19	CCR5	10,14	CD8	CCR5	925	1234	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CCR2 + and CCR5 + CD8 + T cells increase during viral_infection_and_migrate_to_sites_of_infection .
12819030	0	CD8	13,16	CCR5	70,74	CD8	CCR5	925	1234	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|express express|dobj|END_ENTITY	Infiltrating CD8 + T cells in oral_lichen_planus predominantly express CCR5 and CXCR3 and carry respective chemokine ligands RANTES/CCL5 and IP-10 / CXCL10 in their cytolytic granules : a potential self-recruiting mechanism .
20560795	0	CD8	103,106	CCR5	98,102	CD8	CCR5	925	1234	Gene	Gene	numbers|compound|START_ENTITY numbers|compound|END_ENTITY	A novel chemokine-receptor-5 -LRB- CCR5 -RRB- blocker , SCH532706 , has differential effects on CCR5 + CD4 + and CCR5 + CD8 + T cell numbers in chronic_HIV_infection .
22918850	0	CD8	58,61	CCR5	18,22	CD8	CCR5	925	1234	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Downregulation of CCR5 expression on the peripheral blood CD8 + T cells of southeastern Iranian patients with chronic hepatitis_B_infection .
25589222	0	CD8	81,84	CCR5	19,23	CD8	CCR5	925	1234	Gene	Gene	T|compound|START_ENTITY CCR5|nmod|T cells|amod|CCR5 expression|nmod|cells supported|nmod|expression supported|nsubjpass|use use|nmod|antagonists antagonists|nummod|END_ENTITY	Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8 -LRB- + -RRB- T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory_syndrome .
25589222	0	CD8	81,84	CCR5	73,77	CD8	CCR5	925	1234	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Therapeutic use of CCR5 antagonists is supported by strong expression of CCR5 on CD8 -LRB- + -RRB- T cells in progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory_syndrome .
26994221	0	CD8	43,46	CCR5	18,22	CD8	CCR5	925	1234	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	Transient Surface CCR5 Expression by Naive CD8 + T Cells within Inflamed Lymph Nodes Is Dependent on High Endothelial Venule Interaction and Augments Th Cell-Dependent Memory Response .
27068801	0	CD8	78,81	CCR5	11,15	CD8	CCR5	925	1234	Gene	Gene	cells|compound|START_ENTITY T|nmod|cells T|nsubj|role role|nmod|CD4 CD4|compound|END_ENTITY	A role for CCR5 -LRB- + -RRB- CD4 T cells in cutaneous psoriasis and for CD103 -LRB- + -RRB- CCR4 -LRB- + -RRB- CD8 Teff cells in the associated systemic_inflammation .
12594271	0	CD8	53,56	CCR7	57,61	CD8	CCR7	925	1236	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immediate early effector functions of virus-specific CD8 + CCR7 + memory cells in humans defined by HLA and CC_chemokine_ligand_19 tetramers .
14978076	8	CD8	1090,1093	CCR7	1074,1078	CD8	CCR7	925	1236	Gene	Gene	cells|compound|START_ENTITY patrol|nsubj|cells patrol|advcl|seeded seeded|nmod|periphery periphery|appos|CD62L CD62L|compound|END_ENTITY	Once seeded in the periphery , naive CCR7 -LRB- + -RRB- CD62L -LRB- + -RRB- CD8 T cells patrol secondary lymphoid organs , whereas naive CCR7 -LRB- - -RRB- CD62L -LRB- - -RRB- CD8 T cells selectively migrate to peripheral tissues such as skin .
15147571	0	CD8	19,22	CCR7	14,18	CD8	CCR7	925	1236	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Aberration of CCR7 CD8 memory T cells from patients with systemic_lupus_erythematosus : an inducer of T helper type 2 bias of CD4 T cells .
17073944	0	CD8	29,32	CCR7	54,58	CD8	CCR7	925	1236	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Interleukin-4 promotes human CD8 T cell expression of CCR7 .
17148588	0	CD8	34,37	CCR7	58,62	CD8	CCR7	925	1236	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells Cartography|nmod|expression Cartography|dep|END_ENTITY	Cartography of gene expression in CD8 single cells : novel CCR7 - subsets suggest differentiation independent of CD45RA expression .
17529983	0	CD8	46,49	CCR7	20,24	CD8	CCR7	925	1236	Gene	Gene	cells|nummod|START_ENTITY enter|nsubj|cells END_ENTITY|parataxis|enter	L-selectin-negative CCR7 - effector and memory CD8 + T cells enter reactive lymph nodes and kill dendritic cells .
17589293	0	CD8	63,66	CCR7	44,48	CD8	CCR7	925	1236	Gene	Gene	cells|nummod|START_ENTITY fail|nsubj|cells +|ccomp|fail +|nsubj|END_ENTITY	Human_papillomavirus_16 E6-specific CD45RA + CCR7 + high avidity CD8 + T cells fail to control tumor growth despite interferon-gamma production in patients with cervical_cancer .
17634955	0	CD8	34,37	CCR7	38,42	CD8	CCR7	925	1236	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Ephrin-A1 stimulates migration of CD8 + CCR7 + T lymphocytes .
18000950	0	CD8	13,16	CCR7	7,11	CD8	CCR7	925	1236	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells END_ENTITY|parataxis|cells	CXCR5 + CCR7 - CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles .
22821963	0	CD8	0,3	CCR7	11,15	CD8	CCR7	925	1236	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD45RA + CCR7 + FOXP3 + T cells with immunosuppressive properties : a novel subset of inducible human regulatory T cells .
1375001	0	CD8	106,109	CD1	112,115	CD8	CD1	925	911	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
10385079	0	CD8	69,72	CD103	53,58	CD8	CD103	925	3682	Gene	Gene	lymphocytes|compound|START_ENTITY Regulation|nmod|lymphocytes Regulation|nmod|integrin integrin|appos|END_ENTITY	Regulation of the epithelial cell-specific integrin , CD103 , by human CD8 + cytolytic T lymphocytes .
11564161	0	CD8	82,85	CD103	24,29	CD8	CD103	925	3682	Gene	Gene	T|compound|START_ENTITY localization|nmod|T Role|nmod|localization Role|nmod|beta7 beta7|appos|END_ENTITY	Role of integrin alphaE -LRB- CD103 -RRB- beta7 for tissue-specific epidermal localization of CD8 + T lymphocytes .
15196058	0	CD8	71,74	CD103	17,22	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY promoting|nmod|cells END_ENTITY|advcl|promoting	Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells .
15897278	0	CD8	41,44	CD103	21,26	CD8	CD103	925	3682	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	TGF - -LCB- beta -RCB- - dependent CD103 expression by CD8 -LRB- + -RRB- T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host_disease .
16920912	0	CD8	53,56	CD103	0,5	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY marker|nmod|cells marker|nsubj|END_ENTITY	CD103 is a marker for alloantigen-induced regulatory CD8 + T cells .
17452901	0	CD8	65,68	CD103	59,64	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin enhances the number of alloantigen-induced human CD103 + CD8 + regulatory T cells in vitro .
18822329	0	CD8	31,34	CD103	35,40	CD8	CD103	925	3682	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|nummod|END_ENTITY	Alloantigen-induced regulatory CD8 + CD103 + T cells .
19150377	0	CD8	9,12	CD103	35,40	CD8	CD103	925	3682	Gene	Gene	CD28|compound|START_ENTITY CD28|parataxis|express express|dobj|END_ENTITY	Decidual CD8 + CD28 - T cells express CD103 but not perforin .
20541243	0	CD8	22,25	CD103	84,89	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY cells|dep|expressing expressing|dobj|END_ENTITY	Profound elevation of CD8 + T cells expressing the intraepithelial lymphocyte marker CD103 -LRB- alphaE/beta7 Integrin -RRB- in high-grade serous ovarian_cancer .
21778119	0	CD8	50,53	CD103	14,19	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY integrin|nmod|cells integrin|nsubj|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of CD103 -LRB- aEb7 -RRB- integrin expression by CD8 T cells in blood as a surrogate marker to predict cervical T cell responses in the female genital tract during HIV_infection .
22043017	0	CD8	144,147	CD103	5,10	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY presentation|nmod|cells transport|nmod|presentation transport|nsubj|END_ENTITY	Lung CD103 + dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells .
22652413	0	CD8	35,38	CD103	27,32	CD8	CD103	925	3682	Gene	Gene	START_ENTITY|nsubj|intraepithelial intraepithelial|appos|+ +|compound|END_ENTITY	Increased intraepithelial -LRB- CD103 + -RRB- CD8 + T cells in the airways of smokers with and without chronic_obstructive_pulmonary_disease .
22802630	0	CD8	49,52	CD103	20,25	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY +|xcomp|cells +|nsubj|END_ENTITY	Cross-dressed CD8a + / CD103 + dendritic cells prime CD8 + T cells following vaccination .
23562160	0	CD8	64,67	CD103	57,62	CD8	CD103	925	3682	Gene	Gene	effector|compound|START_ENTITY effector|compound|END_ENTITY	Human CD1c + dendritic cells drive the differentiation of CD103 + CD8 + mucosal effector T cells via the cytokine TGF-b .
23861553	0	CD8	63,66	CD103	75,80	CD8	CD103	925	3682	Gene	Gene	Foxp3|compound|START_ENTITY characteristic|nmod|Foxp3 characteristic|dep|+ +|compound|END_ENTITY	Phenotypic and functional characteristic of a newly identified CD8 + Foxp3 - CD103 + regulatory T cells .
24477908	0	CD8	69,72	CD103	43,48	CD8	CD103	925	3682	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|nummod|END_ENTITY	Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes .
25101220	0	CD8	89,92	CD103	30,35	CD8	CD103	925	3682	Gene	Gene	lymphocytes|amod|START_ENTITY demarcates|dobj|lymphocytes demarcates|nsubj|END_ENTITY	Location , location , location : CD103 demarcates intraepithelial , prognostically favorable CD8 -LRB- + -RRB- tumor-infiltrating lymphocytes in ovarian_cancer .
25308332	0	CD8	65,68	CD103	37,42	CD8	CD103	925	3682	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + T cell help guides formation of CD103 + lung-resident memory CD8 + T cells during influenza viral_infection .
25725111	0	CD8	0,3	CD103	4,9	CD8	CD103	925	3682	Gene	Gene	Lymphocytes|compound|START_ENTITY Lymphocytes|compound|END_ENTITY	CD8 + CD103 + Tumor-Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients .
27038842	0	CD8	30,33	CD103	0,5	CD8	CD103	925	3682	Gene	Gene	+|compound|START_ENTITY lymphocytes|nsubj|+ defines|xcomp|lymphocytes defines|nsubj|END_ENTITY	CD103 defines intraepithelial CD8 + PD1 + tumour-infiltrating lymphocytes of prognostic significance in endometrial_adenocarcinoma .
9566785	0	CD8	91,94	CD103	95,100	CD8	CD103	925	3682	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effector T lymphocyte subsets in human pancreatic_cancer : detection of CD8 + CD18 + cells and CD8 + CD103 + cells by multi-epitope imaging .
8859180	0	CD8	34,37	CD11a	25,30	CD8	CD11a	925	3683	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ END_ENTITY|nmod|cells	Functional expression of CD11a on CD8 + cells is suppressed in regional lymph nodes with cancer involvement in patients with gastrointestinal_carcinoma .
9796409	0	CD8	24,27	CD11a	29,34	CD8	CD11a	925	3683	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Remarkable increase of CD8 + CD11a + and CD8 + CD57 - T cells in patients with post-transfusion_graft-versus-host_disease -RSB- .
11035618	0	CD8	18,21	CD11b	29,34	CD8	CD11b	925	3684	Gene	Gene	CD28|compound|START_ENTITY Expansion|nmod|CD28 Expansion|dep|END_ENTITY	Expansion of rare CD8 + CD28 - CD11b - T cells with impaired effector functions in HIV-1-infected patients .
11145666	0	CD8	28,31	CD11b	0,5	CD8	CD11b	925	3684	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T identifies|ccomp|lymphocytes identifies|nsubj|expression expression|amod|END_ENTITY	CD11b expression identifies CD8 + CD28 + T lymphocytes with phenotype and function of both naive/memory and effector cells .
12021304	0	CD8	75,78	CD11b	10,15	CD8	CD11b	925	3684	Gene	Gene	cells|compound|START_ENTITY exogenous|nmod|cells exogenous|nsubj|cells cells|amod|END_ENTITY	CD8alpha - CD11b + dendritic cells present exogenous virus-like particles to CD8 + T cells and subsequently express CD8alpha and CD205 molecules .
1387727	0	CD8	51,54	CD11b	14,19	CD8	CD11b	925	3684	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|nmod|antigen antigen|amod|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
1500720	0	CD8	28,31	CD11b	0,5	CD8	CD11b	925	3684	Gene	Gene	activation|compound|START_ENTITY marker|nmod|activation END_ENTITY|dep|marker	CD11b -LRB- Mac-1 -RRB- : a marker for CD8 + cytotoxic T cell activation and memory in virus_infection .
15067204	0	CD8	98,101	CD11b	83,88	CD8	CD11b	925	3684	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Pharmacological hyperprolactinemia attenuates hydrocortisone-induced expression of CD11b on human CD8 + cells in vivo .
15208607	0	CD8	62,65	CD11b	89,94	CD8	CD11b	925	3684	Gene	Gene	cells|compound|START_ENTITY adhesion|nmod|cells attenuates|dobj|adhesion attenuates|nmod|binding binding|nmod|END_ENTITY	Epigallocatechin_gallate attenuates adhesion and migration of CD8 + T cells by binding to CD11b .
1828937	0	CD8	5,8	CD11b	90,95	CD8	CD11b	925	3684	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells cells|acl:relcl|lack lack|dobj|CD57 CD57|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
1899870	0	CD8	0,3	CD11b	10,15	CD8	CD11b	925	3684	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nummod|+	CD8 + high CD11b + low T cells -LRB- T suppressor-effectors -RRB- in multiple_sclerosis cerebrospinal fluid are increased during high dose corticosteroid treatment .
2023064	0	CD8	108,111	CD11b	113,118	CD8	CD11b	925	3684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Quantitative changes in T helper inducer -LRB- CD4 + CD45RA - -RRB- , T suppressor inducer -LRB- CD4 + CD45RA + -RRB- , T suppressor -LRB- CD8 + CD11b + -RRB- , and T cytotoxic -LRB- CD8 + CD11b - -RRB- subsets in human_immunodeficiency_virus_infection .
2023064	0	CD8	139,142	CD11b	144,149	CD8	CD11b	925	3684	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Quantitative changes in T helper inducer -LRB- CD4 + CD45RA - -RRB- , T suppressor inducer -LRB- CD4 + CD45RA + -RRB- , T suppressor -LRB- CD8 + CD11b + -RRB- , and T cytotoxic -LRB- CD8 + CD11b - -RRB- subsets in human_immunodeficiency_virus_infection .
2502419	0	CD8	0,3	CD11b	4,9	CD8	CD11b	925	3684	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	CD8 + CD11b + peripheral blood T lymphocytes contain lymphokine-activated killer cell precursors .
25024388	0	CD8	100,103	CD11b	21,26	CD8	CD11b	925	3684	Gene	Gene	responses|compound|START_ENTITY promotes|dobj|responses promotes|nsubj|Antigen Antigen|acl|targeting targeting|nmod|cells cells|amod|END_ENTITY	Antigen targeting to CD11b + dendritic cells in association with TLR4/TRIF signaling promotes strong CD8 + T cell responses .
9276527	0	CD8	13,16	CD11b	18,23	CD8	CD11b	925	3684	Gene	Gene	Leu-8|compound|START_ENTITY Leu-8|compound|END_ENTITY	Elevation of CD8 + CD11b + Leu-8 - T cells is associated with the humoral immunodeficiency in myeloma patients .
15294984	0	CD8	82,85	CD11c	31,36	CD8	CD11c	925	3687	Gene	Gene	responses|compound|START_ENTITY cells|nmod|responses +|dobj|cells +|nsubj|activation activation|nmod|END_ENTITY	Partial activation of neonatal CD11c + dendritic cells and induction of adult-like CD8 + cytotoxic T cell responses by synthetic microspheres .
16524567	0	CD8	44,47	CD11c	86,91	CD8	CD11c	925	3687	Gene	Gene	responses|compound|START_ENTITY enhances|dobj|responses enhances|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
16524567	0	CD8	92,95	CD11c	86,91	CD8	CD11c	925	3687	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	4-1BB costimulation enhances HSV-1-specific CD8 + T cell responses by the induction of CD11c + CD8 + T cells .
20479115	0	CD8	111,114	CD11c	69,74	CD8	CD11c	925	3687	Gene	Gene	cells|compound|START_ENTITY homologues|nmod|cells define|nmod|homologues define|dobj|cells cells|amod|END_ENTITY	Superior antigen cross-presentation and XCR1 expression define human CD11c + CD141 + cells as homologues of mouse CD8 + dendritic cells .
20610651	0	CD8	0,3	CD11c	106,111	CD8	CD11c	925	16411(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY serotype|nsubj|responses serotype|ccomp|dependent dependent|nmod|cells cells|amod|END_ENTITY	CD8 + T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c + dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling .
19609979	0	CD8	58,61	CD122	62,67	CD8	CD122	925	16185(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
19609979	0	CD8	6,9	CD122	62,67	CD8	CD122	925	16185(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|dobj|function function|nmod|Treg Treg|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
19609979	6	CD8	948,951	CD122	954,959	CD8	CXCR3	925	12766(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	While CD8 -LRB- + -RRB- CD122 -LRB- + -RRB- CXCR3 -LRB- + -RRB- cells are present in mice , CD8 -LRB- + -RRB- CXCR3 -LRB- + -RRB- cells , but not CD8 -LRB- + -RRB- CD122 -LRB- + -RRB- cells , are present in humans .
16487237	0	CD8	58,61	CD127	0,5	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY altered|nmod|cells altered|nsubjpass|expression expression|compound|END_ENTITY	CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients -- reversal by highly active anti-retroviral therapy -LRB- HAART -RRB- .
16537621	0	CD8	79,82	CD127	54,59	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY interleukin-7_receptor_alpha_chain|nmod|cells interleukin-7_receptor_alpha_chain|appos|END_ENTITY	Expression of the interleukin-7_receptor_alpha_chain -LRB- CD127 -RRB- on virus-specific CD8 + T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis_B_virus infection .
17152014	0	CD8	57,60	CD127	40,45	CD8	CD127	925	3575	Gene	Gene	START_ENTITY|nsubj|memory memory|compound|END_ENTITY	Functionally competent antigen-specific CD127 -LRB- hi -RRB- memory CD8 + T cells are preserved only in HIV-infected individuals receiving early treatment .
17956896	0	CD8	97,100	CD127	82,87	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|shedding shedding|nmod|END_ENTITY	IL-7 decreases IL-7 receptor alpha -LRB- CD127 -RRB- expression and induces the shedding of CD127 by human CD8 + T cells .
18717263	0	CD8	94,97	CD127	33,38	CD8	CD127	925	3575	Gene	Gene	lymphocytes|compound|START_ENTITY Altered|dep|lymphocytes Altered|dep|expression expression|nmod|survival survival|appos|END_ENTITY	-LSB- Altered expression of survival -LRB- CD127 -RRB- and death -LRB- Fas -RRB- receptors in total , na ve and memory CD8 T lymphocytes from human immunodeficiency virus_infected patients : possible implications for progression of infection -RSB- .
19011158	0	CD8	66,69	CD127	70,75	CD8	CD127	925	3575	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
19147839	0	CD8	86,89	CD127	66,71	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells .
19350559	0	CD8	73,76	CD127	12,17	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells correlates|nmod|apoptosis correlates|nsubj|down-regulation down-regulation|compound|END_ENTITY	Progressive CD127 down-regulation correlates with increased apoptosis of CD8 T cells during chronic_HIV-1_infection .
20130059	0	CD8	118,121	CD127	164,169	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY cells|acl|defined defined|nmod|alpha alpha|appos|END_ENTITY	Proliferation capacity and cytotoxic activity are mediated by functionally and phenotypically distinct virus-specific CD8 T cells defined by interleukin-7R -LCB- alpha -RCB- -LRB- CD127 -RRB- and perforin expression .
20807412	0	CD8	47,50	CD127	20,25	CD8	CD127	925	3575	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|expression expression|nummod|END_ENTITY	Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic_hepatitis_B during telbivudine treatment .
21740271	0	CD8	68,71	CD127	48,53	CD8	CD127	925	3575	Gene	Gene	alters|nmod|START_ENTITY alters|dobj|expression expression|compound|END_ENTITY	In vitro HIV_Type_1 infection indirectly alters CD127 expression on CD8 -LRB- + -RRB- T cells .
23965471	0	CD8	66,69	CD127	132,137	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY increased|nmod|cells increased|nmod|downregulation downregulation|nmod|END_ENTITY	HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127 .
25231631	0	CD8	62,65	CD127	99,104	CD8	CD127	925	3575	Gene	Gene	subset|nmod|START_ENTITY subset|dep|cells cells|acl|characterized characterized|nmod|expression expression|compound|END_ENTITY	Human bone marrow contains a subset of quiescent early memory CD8 -LRB- + -RRB- T cells characterized by high CD127 expression and efflux capacity .
25986373	0	CD8	64,67	CD127	49,54	CD8	CD127	925	3575	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat 's Basic Region .
25986373	0	CD8	64,67	CD127	49,54	CD8	CD127	925	3575	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat 's Basic Region .
26272555	0	CD8	114,117	CD127	46,51	CD8	CD127	925	3575	Gene	Gene	cells|compound|START_ENTITY proteasome|nmod|cells induces|nmod|proteasome induces|dobj|endocytosis endocytosis|nmod|END_ENTITY	IL-7 induces clathrin-mediated endocytosis of CD127 and subsequent degradation by the proteasome in primary human CD8 T cells .
18390707	0	CD8	23,26	CD137	0,5	CD8	CD137	925	3604	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells costimulation|nummod|END_ENTITY	CD137 costimulation of CD8 + T cells confers resistance to suppression by virus-induced regulatory T cells .
1387727	0	CD8	51,54	CD16	57,61	CD8	CD16	925	2214	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
1828937	0	CD8	5,8	CD16	97,101	CD8	CD16	925	2214	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells cells|acl:relcl|lack lack|dobj|CD57 CD57|appos|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18768879	0	CD8	53,56	CD16	37,41	CD8	CD16	925	2214	Gene	Gene	cells|compound|START_ENTITY effector|dobj|cells effector|nsubj|numbers numbers|nmod|+ +|appos|+ +|compound|END_ENTITY	Elevated numbers of Fc gamma RIIIA + -LRB- CD16 + -RRB- effector CD8 T cells with NK cell-like function in chronic_hepatitis_C_virus_infection .
2150319	0	CD8	97,100	CD16	0,4	CD8	CD16	925	2214	Gene	Gene	CD3|compound|START_ENTITY depletion|nmod|CD3 decrease|nmod|depletion decrease|nsubj|cells cells|compound|END_ENTITY	CD16 + NK cells decrease in all stages of HIV_infection through a selective depletion of the CD16 + CD8 + CD3 - subset .
2150319	0	CD8	97,100	CD16	92,96	CD8	CD16	925	2214	Gene	Gene	CD3|compound|START_ENTITY CD3|compound|END_ENTITY	CD16 + NK cells decrease in all stages of HIV_infection through a selective depletion of the CD16 + CD8 + CD3 - subset .
2346908	0	CD8	114,117	CD16	120,124	CD8	CD16	925	2214	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|+ +|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
2525425	2	CD8	69,72	CD16	73,77	CD8	CD16	925	2214	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Frequency and clonal specificity of CD8 + CD16 - -LRB- Leu2 + Leu11 - -RRB- and CD16 + CD3 - -LRB- Leu11 + Leu4 - -RRB- cytotoxic lymphocyte precursors activated by alloantigen or K562 stimulator cells .
3259141	0	CD8	35,38	CD16	41,45	CD8	CD16	925	2214	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Selective depletion of low-density CD8 + , CD16 + lymphocytes during HIV_infection .
8181530	0	CD8	75,78	CD16	91,95	CD8	CD16	925	2214	Gene	Gene	proliferation|nmod|START_ENTITY Inhibition|nmod|proliferation +|nsubj|Inhibition +|nmod|cells cells|nummod|END_ENTITY	Inhibition of anti-GD3-ganglioside antibody-induced proliferation of human CD8 + T cells by CD16 + natural killer cells .
16638798	0	CD8	16,19	CD161	10,15	CD8	CD161	925	3820	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Decreased CD161 + CD8 + T cells in the peripheral blood of patients suffering from rheumatic_diseases .
18219672	0	CD8	47,50	CD161	0,5	CD8	CD161	925	3820	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD161 expression on hepatitis_C virus-specific CD8 + T cells suggests a distinct pathway of T cell differentiation .
20133607	0	CD8	38,41	CD161	12,17	CD8	CD161	925	3820	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Analysis of CD161 expression on human CD8 + T cells defines a distinct functional subset with tissue-homing properties .
22100877	0	CD8	68,71	CD161	30,35	CD8	CD161	925	3820	Gene	Gene	+|dep|START_ENTITY cells|appos|+ END_ENTITY|dep|cells	Depletion of pro-inflammatory CD161 -LRB- + -RRB- double negative -LRB- CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- -RRB- T cells in AIDS patients is ameliorated by expansion of the y T cell population .
23527216	0	CD8	52,55	CD161	28,33	CD8	CD161	925	3820	Gene	Gene	cells|compound|START_ENTITY Identification|dep|cells Identification|nmod|END_ENTITY	Identification of cytolytic CD161 - CD56 + regulatory CD8 T cells in human peripheral blood .
24391773	0	CD8	32,35	CD161	25,30	CD8	CD161	925	3820	Gene	Gene	mucosal|compound|START_ENTITY mucosal|compound|END_ENTITY	Low levels of peripheral CD161 + + CD8 + mucosal associated invariant T -LRB- MAIT -RRB- cells are found in HIV_and_HIV / TB_co-infection .
24391773	7	CD8	1196,1199	CD161	1189,1194	CD8	CD161	925	3820	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Acute and chronic HIV were associated with lower frequencies of CD161 + + CD8 + T cells , which did not correlate with CD4 count or HIV viral load .
25960619	11	CD8	1012,1015	CD161	1016,1021	CD4	CD161	920	3820	Gene	Gene	percentage|compound|START_ENTITY percentage|compound|END_ENTITY	However , CD8 + CD161 + T cell percentage was neither changed in RA_PB and SF nor correlated with disease activity indices .
26220166	0	CD8	10,13	CD161	0,5	CD8	CD161	925	3820	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dep|cells	CD161 -LRB- int -RRB- CD8 + T cells : a novel population of highly functional , memory CD8 + T cells enriched within the gut .
26220166	0	CD8	72,75	CD161	0,5	CD8	CD161	925	3820	Gene	Gene	T|compound|START_ENTITY memory|dep|T functional|dep|memory cells|amod|functional population|nmod|cells END_ENTITY|dep|population	CD161 -LRB- int -RRB- CD8 + T cells : a novel population of highly functional , memory CD8 + T cells enriched within the gut .
19088063	0	CD8	29,32	CD18	33,37	CD8	CD18	925	3689	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Could the lower frequency of CD8 + CD18 + CD45RO + lymphocytes be biomarkers of human VL ?
9566785	0	CD8	71,74	CD18	75,79	CD8	CD18	925	3689	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effector T lymphocyte subsets in human pancreatic_cancer : detection of CD8 + CD18 + cells and CD8 + CD103 + cells by multi-epitope imaging .
2346908	0	CD8	114,117	CD2	96,99	CD8	CD2	925	914	Gene	Gene	-|compound|START_ENTITY +|appos|- +|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
11587221	0	CD8	119,122	CD20	0,4	CD8	CD20	925	54474	Gene	Gene	cells|nummod|START_ENTITY antibody|nmod|cells antibody|nummod|END_ENTITY	CD20 antibody -LRB- C2B8 -RRB- - induced apoptosis of lymphoma cells promotes phagocytosis by dendritic cells and cross-priming of CD8 + cytotoxic T cells .
12580963	0	CD8	13,16	CD20	82,86	CD8	CD20	925	54474	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|express express|dobj|levels levels|nmod|END_ENTITY	Expansion of CD8 + T cells that express low levels of the B cell-specific molecule CD20 in patients with multiple_myeloma .
16753590	0	CD8	18,21	CD20	8,12	CD8	CD20	925	54474	Gene	Gene	T-cell_lymphoma|compound|START_ENTITY +|dobj|T-cell_lymphoma +|nsubj|END_ENTITY	Primary CD20 + CD10 + CD8 + T-cell_lymphoma of the skin with IgH and TCR_beta gene rearrangement .
21574977	0	CD8	155,158	CD20	167,171	CD8	CD20	925	54474	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immunophenotype of skin lymphocytic infiltrate in patients co-infected with Mycobacterium_leprae and human_immunodeficiency_virus : a scenario dependent on CD8 + and/or CD20 + cells .
22553348	0	CD8	95,98	CD20	0,4	CD8	CD20	925	54474	Gene	Gene	cells|compound|START_ENTITY together|nmod|cells have|advmod|together have|nsubj|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	CD20 + tumor-infiltrating lymphocytes have an atypical CD27 - memory phenotype and together with CD8 + T cells promote favorable prognosis in ovarian_cancer .
23683422	0	CD8	21,24	CD20	63,67	CD8	CD20	925	54474	Gene	Gene	cytotoxic_T-cell_lymphoma|compound|START_ENTITY coexpressed|nsubj|cytotoxic_T-cell_lymphoma coexpressed|dobj|END_ENTITY	-LSB- Primary bone marrow CD8 cytotoxic_T-cell_lymphoma coexpressed CD20 : a case report and literatures review -RSB- .
26109642	0	CD8	30,33	CD226	10,15	CD8	CD226	925	10666	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	Increased CD226 Expression on CD8 + T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic_Sclerosis .
11466326	0	CD8	25,28	CD25	55,59	CD8	CD25	925	3559	Gene	Gene	activation|compound|START_ENTITY control|nmod|activation control|nmod|cells cells|compound|END_ENTITY	Cutting edge : control of CD8 + T cell activation by CD4 + CD25 + immunoregulatory cells .
12421913	0	CD8	85,88	CD25	18,22	CD8	CD25	925	3559	Gene	Gene	rejection|compound|START_ENTITY prevent|dobj|rejection cells|acl:relcl|prevent cells|compound|END_ENTITY	Cutting edge : CD4 + CD25 + alloantigen-specific immunoregulatory cells that can prevent CD8 + T cell-mediated graft rejection : implications for anti-CD154 immunotherapy .
14722622	0	CD8	77,80	CD25	4,8	CD8	CD25	925	3559	Gene	Gene	cells|compound|START_ENTITY mediated|nmod|cells rejection|acl|mediated suppress|dobj|rejection +|ccomp|suppress +|nsubj|END_ENTITY	CD4 + CD25 + regulatory T cells suppress allograft rejection mediated by memory CD8 + T cells via a CD30-dependent mechanism .
15293135	0	CD8	11,14	CD25	16,20	CD8	CD25	925	3559	Gene	Gene	+|compound|START_ENTITY +|parataxis|implicated implicated|nsubjpass|lymphocytes lymphocytes|compound|END_ENTITY	Peripheral CD8 + / CD25 + lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune_hepatitis .
15447720	0	CD8	57,60	CD25	52,56	CD8	CD25	925	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Correlation of psoriasis activity with abundance of CD25 + CD8 + T cells : conditions for cloning T cells from psoriatic plaques .
15600300	0	CD8	102,105	CD25	96,100	CD8	CD25	925	3559	Gene	Gene	expression|dep|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
15731226	0	CD8	18,21	CD25	47,51	CD8	CD25	925	3559	Gene	Gene	+|compound|START_ENTITY Modulation|nmod|+ Modulation|dep|response response|nmod|END_ENTITY	Modulation of the CD8 + - T-cell response by CD4 + CD25 + regulatory T cells in patients with hepatitis_B_virus infection .
15968737	0	CD8	64,67	CD25	13,17	CD8	CD25	925	16184(Tax:10090)	Gene	Gene	response|compound|START_ENTITY enhances|dobj|response enhances|nsubj|Depletion Depletion|nmod|cells cells|compound|END_ENTITY	Depletion of CD25 + CD4 + T cells -LRB- Tregs -RRB- enhances the HBV-specific CD8 + T cell response primed by DNA immunization .
16005184	0	CD8	43,46	CD25	15,19	CD8	CD25	925	3559	Gene	Gene	function|compound|START_ENTITY +|nmod|function +|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CD4 + CD25 + regulatory T-cells on CD8 T-cell function in patients with autoimmune_hepatitis .
16167085	0	CD8	86,89	CD25	90,94	CD8	CD25	925	3559	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	TCR stimulation with modified anti-CD3 mAb expands CD8 + T cell population and induces CD8 + CD25 + Tregs .
16219576	0	CD8	44,47	CD25	19,23	CD8	CD25	925	3559	Gene	Gene	START_ENTITY|nsubj|association association|nmod|expression expression|nummod|END_ENTITY	The association of CD25 expression on donor CD8 + and CD4 + T cells with graft-versus-host disease after donor lymphocyte infusions .
16443370	0	CD8	47,50	CD25	18,22	CD8	CD25	925	3559	Gene	Gene	+|compound|START_ENTITY Treg|nmod|+ Treg|compound|END_ENTITY	The impact of CD4 + CD25 + Treg on tumor specific CD8 + T cell cytotoxicity and cancer .
16902287	8	CD8	1551,1554	CD25	1556,1560	CD4	CD25	920	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased numbers of pathogenic T cells -LRB- CD4 + CD25 + , CD4 + CD45RO + , CD8 + CD25 + and CD8 + CD45RO + -RRB- were shown in the dermis and epidermis , whereas CD4 + CD25 + Foxp3 + T -LRB- reg -RRB- were identified in psoriatic skin with a predilection for the upper dermis .
16982886	0	CD8	63,66	CD25	44,48	CD8	CD25	925	3559	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|compound|END_ENTITY	Ligation of CD80 is critical for high-level CD25 expression on CD8 + T lymphocytes .
17258077	0	CD8	45,48	CD25	51,55	CD8	CD25	925	3559	Gene	Gene	IL-2-independent|dep|START_ENTITY IL-2-independent|dep|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17898053	0	CD8	13,16	CD25	7,11	CD8	CD25	925	3559	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
18780874	0	CD8	32,35	CD25	42,46	CD8	CD25	925	3559	Gene	Gene	CD28|compound|START_ENTITY frequency|nmod|CD28 frequency|dep|lymphocytes lymphocytes|nummod|END_ENTITY	The frequency of regulatory CD3 + CD8 + CD28 - CD25 + T lymphocytes in human peripheral blood increases with age .
18953723	0	CD8	15,18	CD25	26,30	CD8	CD25	925	3669	Gene	Gene	T-lymphocytes|compound|START_ENTITY T-lymphocytes|compound|END_ENTITY	Non-regulatory CD8 + CD45RO + CD25 + T-lymphocytes may compensate for the loss of antigen-inexperienced CD8 + CD45RA + T-cells in old age .
18953723	0	CD8	99,102	CD25	26,30	CD8	CD25	925	3669	Gene	Gene	T-cells|compound|START_ENTITY loss|nmod|T-cells compensate|nmod|loss compensate|nsubj|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Non-regulatory CD8 + CD45RO + CD25 + T-lymphocytes may compensate for the loss of antigen-inexperienced CD8 + CD45RA + T-cells in old age .
19022917	0	CD8	18,21	CD25	22,26	CD8	CD25	925	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal_cancer tissue .
19966302	0	CD8	87,90	CD25	26,30	CD8	CD25	925	3559	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells controls|dobj|development controls|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses .
20437560	0	CD8	8,11	CD25	13,17	CD8	CD25	925	3559	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	Role of CD8 + CD25 + Foxp3 + regulatory T cells in multiple_sclerosis .
21092106	0	CD8	79,82	CD25	4,8	CD8	CD25	925	493953(Tax:9685)	Gene	Gene	targets|compound|START_ENTITY induce|nmod|targets T|ccomp|induce T|nsubj|+ +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells from FIV + cats induce a unique anergic profile in CD8 + lymphocyte targets .
21108468	0	CD8	45,48	CD25	5,9	CD8	CD25	925	3559	Gene	Gene	subsets|compound|START_ENTITY contribution|nmod|subsets regulate|dobj|contribution regulate|nsubj|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Treg regulate the contribution of CD8 + T-cell subsets in repopulation of the lymphopenic environment .
21518973	0	CD8	67,70	CD25	4,8	CD8	CD25	925	3559	Gene	Gene	lung_inflammation|compound|START_ENTITY dispensable|nmod|lung_inflammation +|ccomp|dispensable +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
21652515	0	CD8	91,94	CD25	4,8	CD8	CD25	925	3559	Gene	Gene	CD28-CTL|compound|START_ENTITY activity|nmod|CD28-CTL enhance|dobj|activity +|ccomp|enhance +|nsubj|FoxP3 FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
22609353	0	CD8	64,67	CD25	68,72	CD8	CD25	925	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22824748	0	CD8	17,20	CD25	21,25	CD8	CD25	925	3559	Gene	Gene	FOXP3|compound|START_ENTITY FOXP3|compound|END_ENTITY	Low frequency of CD8 + CD25 + FOXP3 -LRB- BRIGHT -RRB- T cells and FOXP3 mRNA expression in the peripheral blood of allergic_asthma patients .
24244610	0	CD8	14,17	CD25	34,38	CD8	CD25	925	3559	Gene	Gene	+|compound|START_ENTITY ratios|nmod|+ T|nsubj|ratios T|nmod|+ +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
25316133	0	CD8	37,40	CD25	41,45	CD8	CD25	925	3559	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|compound|END_ENTITY	Allergy-related changes in levels of CD8 + CD25 + FoxP3 -LRB- bright -RRB- Treg cells and FoxP3 mRNA expression in peripheral blood : the role of IL-10 or TGF-beta .
25921629	0	CD8	23,26	CD25	27,31	CD8	CD25	925	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The relative values of CD8 + CD25 + Foxp3brigh Treg cells correlate with selected lung function parameters in asthma .
26155145	0	CD8	16,19	CD25	4,8	CD8	CD25	925	3559	Gene	Gene	CD28|compound|START_ENTITY END_ENTITY|appos|CD28	CD4 + CD25 -LRB- high -RRB- , CD8 + CD28 - cells and thyroid autoantibodies in breast_cancer patients .
8255102	0	CD8	39,42	CD25	44,48	CD8	CD25	925	3559	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|CD71 CD71|compound|END_ENTITY	Soluble CD23 and other receptors -LRB- CD4 , CD8 , CD25 , CD71 -RRB- in serum of patients with chronic_lymphocytic_leukemia .
12370498	0	CD8	51,54	CD27	45,49	CD8	CD27	925	939	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Lack of Epstein-Barr_virus - and HIV-specific CD27 - CD8 + T cells is associated with progression to viral_disease in HIV-infection .
12464570	0	CD8	47,50	CD27	71,75	CD8	CD27	925	939	Gene	Gene	maturation|compound|START_ENTITY result|nmod|maturation Failing|nmod|result Failing|parataxis|provide provide|nsubj|END_ENTITY	Failing immune control as a result of impaired CD8 + T-cell maturation : CD27 might provide a clue .
15048710	0	CD8	35,38	CD27	130,134	CD8	CD27	925	939	Gene	Gene	cells|compound|START_ENTITY classification|nmod|cells classification|dep|correlation correlation|nmod|expression expression|nmod|END_ENTITY	Phenotypic classification of human CD8 + T cells reflecting their function : inverse correlation between quantitative expression of CD27 and cytotoxic effector function .
17159138	0	CD8	64,67	CD27	0,4	CD8	CD27	925	939	Gene	Gene	cell|compound|START_ENTITY expansion|nmod|cell mediates|dobj|expansion mediates|nsubj|END_ENTITY	CD27 mediates interleukin-2-independent clonal expansion of the CD8 + T cell without effector differentiation .
18506879	0	CD8	26,29	CD27	57,61	CD8	CD27	925	939	Gene	Gene	memory|compound|START_ENTITY memory|nmod|expression expression|compound|END_ENTITY	CD4 + T cell help improves CD8 + T cell memory by retained CD27 expression .
18606659	0	CD8	59,62	CD27	0,4	CD8	CD27	925	939	Gene	Gene	response|nummod|START_ENTITY provide|nmod|response instructs|xcomp|provide instructs|nsubj|END_ENTITY	CD27 instructs CD4 + T cells to provide help for the memory CD8 + T cell response after protein immunization .
21048108	0	CD8	67,70	CD27	85,89	CD8	CD27	925	939	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells signaling|nmod|costimulation costimulation|compound|END_ENTITY	The Pim kinase pathway contributes to survival signaling in primed CD8 + T cells upon CD27 costimulation .
22553348	0	CD8	95,98	CD27	54,58	CD8	CD27	925	939	Gene	Gene	cells|compound|START_ENTITY together|nmod|cells have|advmod|together have|dobj|END_ENTITY	CD20 + tumor-infiltrating lymphocytes have an atypical CD27 - memory phenotype and together with CD8 + T cells promote favorable prognosis in ovarian_cancer .
23017234	0	CD8	90,93	CD27	82,86	CD8	CD27	925	939	Gene	Gene	T-cells|compound|START_ENTITY T-cells|amod|END_ENTITY	Acute aerobic exercise in humans increases cytokine expression in CD27 -LRB- - -RRB- but not CD27 -LRB- + -RRB- CD8 -LRB- + -RRB- T-cells .
24002868	0	CD8	83,86	CD27	0,4	CD8	CD27	925	939	Gene	Gene	T|compound|START_ENTITY expansion|nmod|T substantially|nmod|expansion cells|amod|substantially contributes|dobj|cells contributes|nsubj|costimulation costimulation|compound|END_ENTITY	CD27 costimulation contributes substantially to the expansion of functional memory CD8 -LRB- + -RRB- T cells after peptide immunization .
24391889	0	CD8	12,15	CD27	7,11	CD8	CD27	925	939	Gene	Gene	percentages|compound|START_ENTITY percentages|compound|END_ENTITY	Higher CD27 + CD8 + T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4 + T cell recovery in treated HIV_infection .
24860188	0	CD8	75,78	CD27	23,27	CD8	CD27	925	939	Gene	Gene	generation|compound|START_ENTITY costimulation|dobj|generation costimulation|nsubj|impact impact|nmod|END_ENTITY	Differential impact of CD27 and 4-1BB costimulation on effector and memory CD8 T cell generation following peptide immunization .
10069421	0	CD8	25,28	CD28	83,87	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY Differentiation|nmod|cells Differentiation|dep|implications implications|nmod|persistence persistence|nmod|END_ENTITY	Differentiation of human CD8 T cells : implications for in vivo persistence of CD8 + CD28 - cytotoxic effector clones .
10193418	0	CD8	31,34	CD28	14,18	CD8	CD28	925	940	Gene	Gene	T|compound|START_ENTITY Expression|nmod|T Expression|nmod|END_ENTITY	Expression of CD28 and CD38 by CD8 + T lymphocytes in HIV-1_infection correlates with markers of disease severity and changes towards normalization under treatment .
10331493	0	CD8	131,134	CD28	14,18	CD8	CD28	925	940	Gene	Gene	CD28|compound|START_ENTITY number|nmod|CD28 accounting|nmod|number Generation|dep|accounting Generation|nmod|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD8	131,134	CD28	56,60	CD8	CD28	925	940	Gene	Gene	CD28|compound|START_ENTITY number|nmod|CD28 accounting|nmod|number Generation|dep|accounting Generation|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD8	52,55	CD28	135,139	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Generation|dep|cells Generation|dep|accounting accounting|nmod|number number|nmod|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD8	52,55	CD28	14,18	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Generation|dep|cells Generation|nmod|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD8	52,55	CD28	56,60	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10421790	0	CD8	17,20	CD28	57,61	CD8	CD28	925	940	Gene	Gene	CD28|compound|START_ENTITY T|nsubj|CD28 T|ccomp|give give|nmod|progeny progeny|compound|END_ENTITY	Peripheral human CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T lymphocytes give rise to CD28 -LRB- - -RRB- progeny , but IL-4 prevents loss of CD28 expression .
10583606	0	CD8	102,105	CD28	96,100	CD8	CD28	925	940	Gene	Gene	population|compound|START_ENTITY population|dep|lymphocytes lymphocytes|nmod|END_ENTITY	Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57 + CD28 - CD8 + T-cell population .
10882412	0	CD8	27,30	CD28	8,12	CD8	CD28	925	940	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Loss of CD28 expression on CD8 -LRB- + -RRB- T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN , and increases susceptibility to activation-induced apoptosis .
10964536	0	CD8	46,49	CD28	68,72	CD8	CD28	925	940	Gene	Gene	T-cells|compound|START_ENTITY T-cells|nmod|costimulation costimulation|compound|END_ENTITY	Response differences between human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T-cells during CD28 costimulation : implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging .
11145666	0	CD8	28,31	CD28	32,36	CD8	CD28	925	940	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD11b expression identifies CD8 + CD28 + T lymphocytes with phenotype and function of both naive/memory and effector cells .
11887352	0	CD8	66,69	CD28	33,37	CD8	CD28	925	940	Gene	Gene	T|compound|START_ENTITY antigen|nmod|T antigen|compound|END_ENTITY	-LSB- Expression of the costimulatory CD28 antigen on peripheral blood CD8 + T lymphocytes in patients with chronic hepatitis_C -RSB- .
11985525	0	CD8	45,48	CD28	40,44	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A reduction in the number of peripheral CD28 + CD8 + T cells in the acute phase of influenza .
12390853	0	CD8	13,16	CD28	30,34	CD8	CD28	925	940	Gene	Gene	Analysis|nmod|START_ENTITY END_ENTITY|nsubj|Analysis	-LSB- Analysis of CD8 -LRB- + -RRB- and CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- cell subsets in patients with hepatocellular_carcinoma -RSB- .
12391201	0	CD8	102,105	CD28	0,4	CD8	CD28	925	12487(Tax:10090)	Gene	Gene	T|compound|START_ENTITY cross-priming|nmod|T critical|nmod|cross-priming cells|amod|critical cells|nsubj|END_ENTITY	CD28 , TNF receptor , and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8 + T cells .
12392852	0	CD8	50,53	CD28	77,81	CD8	CD28	925	940	Gene	Gene	CD28|compound|START_ENTITY regulation|nmod|CD28 regulation|nmod|END_ENTITY	Proliferative_arrest and cell cycle regulation in CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- versus CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T cells .
12392852	0	CD8	71,74	CD28	56,60	CD8	CD28	925	940	Gene	Gene	CD28|compound|START_ENTITY regulation|nmod|CD28 regulation|nmod|END_ENTITY	Proliferative_arrest and cell cycle regulation in CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- versus CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T cells .
12519392	0	CD8	65,68	CD28	132,136	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY recognized|nmod|cells recognized|nmod|flow-assisted flow-assisted|nmod|END_ENTITY	Definition of the HLA-A2 restricted peptides recognized by human CD8 + effector T cells by flow-assisted sorting of the CD8 + CD45RA + CD28 - T cell subpopulation .
12626553	0	CD8	34,37	CD28	0,4	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells enhances|dobj|apoptosis enhances|nsubj|signal signal|compound|END_ENTITY	CD28 signal enhances apoptosis of CD8 T cells after strong TCR ligation .
12882659	0	CD8	14,17	CD28	58,62	CD8	CD28	925	940	Gene	Gene	nonlytic|compound|START_ENTITY Production|nmod|nonlytic suppressive|nsubj|Production suppressive|nmod|END_ENTITY	Production of CD8 + T cell nonlytic suppressive factors by CD28 , CD38 , and HLA-DR subpopulations .
12963692	0	CD8	40,43	CD28	15,19	CD8	CD28	925	940	Gene	Gene	effector|compound|START_ENTITY Restoration|dep|effector Restoration|nmod|expression expression|nummod|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
12963692	0	CD8	40,43	CD28	34,38	CD8	CD28	925	940	Gene	Gene	effector|compound|START_ENTITY Restoration|dep|effector Restoration|nmod|expression expression|nmod|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
14969769	0	CD8	20,23	CD28	69,73	CD8	CD28	925	940	Gene	Gene	suppressor|compound|START_ENTITY lymphocytes|nsubj|suppressor lymphocytes|dep|originate originate|nmod|END_ENTITY	Nonantigen specific CD8 + T suppressor lymphocytes originate from CD8 + CD28 - T cells and inhibit both T-cell proliferation and CTL function .
15096190	0	CD8	7,10	CD28	122,126	CD8	CD28	925	12487(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY superior|nsubj|expansion superior|nmod|END_ENTITY	Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L -LRB- 4-1BBL -RRB- is superior to CD28 , and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo .
15473875	0	CD8	46,49	CD28	51,55	CD8	CD28	925	940	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Growth_hormone -LRB- GH -RRB- - induced reconstitution of CD8 + CD28 + T lymphocytes in a rare case of severe lymphopenia associated with Juvenile_Haemochromatosis and Turner 's _ syndrome .
15719742	0	CD8	22,25	CD28	34,38	CD8	CD28	925	940	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Relationship between CD8 + T-cell CD28 expression and TCM differentiation type in patients with chronic_aplastic_anemia -RSB- .
16002671	0	CD8	62,65	CD28	15,19	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-21 sustains CD28 expression on IL-15-activated human naive CD8 + T cells .
1676547	0	CD8	25,28	CD28	112,116	CD8	CD28	925	940	Gene	Gene	lymphocytes|compound|START_ENTITY Activation|nmod|lymphocytes Activation|dep|evidence evidence|nmod|transcription transcription|acl|mediated mediated|nmod|activation activation|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
1676547	0	CD8	25,28	CD28	48,52	CD8	CD28	925	940	Gene	Gene	lymphocytes|compound|START_ENTITY Activation|nmod|lymphocytes Activation|nmod|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
17114476	0	CD8	42,45	CD28	7,11	CD8	CD28	925	940	Gene	Gene	resistance|compound|START_ENTITY required|nmod|resistance required|nsubjpass|costimulation costimulation|compound|END_ENTITY	Direct CD28 costimulation is required for CD8 + T cell-mediated resistance to an acute_viral_disease in a natural host .
17173839	0	CD8	46,49	CD28	50,54	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Functional and phenotypic characterization of CD8 + CD28 + and CD28 - T cells in atopic individuals sensitized to Dermatophagoides_pteronyssinus .
17878391	0	CD8	55,58	CD28	21,25	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ generating|dobj|lymphocytes END_ENTITY|advcl|generating	4-1BB is superior to CD28 costimulation for generating CD8 + cytotoxic lymphocytes for adoptive immunotherapy .
17982038	0	CD8	7,10	CD28	28,32	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY require|nsubj|cells require|dobj|costimulation costimulation|compound|END_ENTITY	Memory CD8 + T cells require CD28 costimulation .
18162511	0	CD8	33,36	CD28	14,18	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|nummod|END_ENTITY	Regulation of CD28 expression on CD8 + T cells by CTLA-4 .
18563290	0	CD8	26,29	CD28	30,34	CD8	CD28	925	940	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Decrease in CD4 + CD25 + and CD8 + CD28 + T cells in interstitial_pneumonitis associated with rheumatic_disease .
18570590	0	CD8	99,102	CD28	42,46	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY ve|dobj|+ cells|dep|ve maturation|nmod|cells prevents|nmod|maturation prevents|dobj|loss loss|nmod|expression expression|compound|END_ENTITY	HIV-1 matrix protein p17 prevents loss of CD28 expression during IL-2-induced maturation of na ve CD8 -LRB- + -RRB- T cells .
18751903	0	CD8	108,111	CD28	112,116	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Microarray analysis reveals similarity between CD8 + CD28 - T cells from young and elderly persons , but not of CD8 + CD28 + T cells .
19797296	0	CD8	86,89	CD28	80,84	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28 + CD8 memory T cells throughout the adult age span .
20030671	0	CD8	93,96	CD28	97,101	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	T-cell activation profiles in different granulomatous interstitial_lung_diseases -- a role for CD8 + CD28 -LRB- null -RRB- cells ?
20721608	0	CD8	86,89	CD28	10,14	CD8	CD28	925	940	Gene	Gene	lymphocytes|compound|START_ENTITY senescence|nmod|lymphocytes features|nmod|senescence delays|dep|features delays|compound|END_ENTITY	Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes .
21493800	0	CD8	112,115	CD28	135,139	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY generation|nmod|cells enhances|dobj|generation Priming|dep|enhances Priming|nsubj|END_ENTITY	Priming CD8 + T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8 + T cells retaining CD28 .
21493800	0	CD8	8,11	CD28	135,139	CD8	CD28	925	940	Gene	Gene	cells|nummod|START_ENTITY Priming|dobj|cells Priming|nsubj|END_ENTITY	Priming CD8 + T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8 + T cells retaining CD28 .
22503210	0	CD8	40,43	CD28	91,95	CD8	CD28	925	940	Gene	Gene	cells|nsubj|START_ENTITY co-stimulates|xcomp|cells co-stimulates|dep|receptor receptor|nummod|END_ENTITY	Tumor PD-L1 co-stimulates primary human CD8 -LRB- + -RRB- cytotoxic T cells modified to express a PD1 : CD28 chimeric receptor .
22851040	0	CD8	11,14	CD28	16,20	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	0	CD8	11,14	CD28	29,33	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY Balance|nmod|+ END_ENTITY|dep|Balance	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	0	CD8	24,27	CD28	16,20	CD8	CD28	925	940	Gene	Gene	CD28|compound|START_ENTITY CD28|dep|Balance Balance|nmod|+ +|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	11	CD8	1622,1625	CD28	1627,1631	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CONCLUSIONS : The balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes plays a vital role in UC , while the balance tilt towards CD8 + CD28 + T lymphocytes is beneficial for patients with UC .
23711708	0	CD8	104,107	CD28	109,113	CD8	CD28	925	940	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8 + CD28 + T lymphocyte responses .
23786396	0	CD8	10,13	CD28	14,18	CD8	CD28	925	940	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Defective CD8 + CD28 + regulatory T cell suppressor function in rheumatoid_arthritis is restored by tumour necrosis factor inhibitor therapy .
24152837	0	CD8	81,84	CD28	54,58	CD8	CD28	925	940	Gene	Gene	CD28|compound|START_ENTITY TGF-beta|nmod|CD28 TGF-beta|nmod|activation activation|compound|END_ENTITY	The effects of interleukin-10 or TGF-beta on anti-CD3 / CD28 induced activation of CD8 + CD28 - and CD8 + CD28 + T cells in allergic_asthma .
24152837	0	CD8	95,98	CD28	99,103	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of interleukin-10 or TGF-beta on anti-CD3 / CD28 induced activation of CD8 + CD28 - and CD8 + CD28 + T cells in allergic_asthma .
24432600	0	CD8	25,28	CD28	29,33	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- The value of changes in CD8 + CD28 + and CD4 + CD28 + cells in patients with HIV_infection concurrent with tuberculosis during treatment -RSB- .
24585893	0	CD8	25,28	CD28	19,23	CD8	CD28	925	940	Gene	Gene	cells|nummod|START_ENTITY proportions|dep|cells proportions|nmod|END_ENTITY	Low proportions of CD28 - CD8 + T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV_infection .
24842641	0	CD8	42,45	CD28	27,31	CD8	CD28	925	940	Gene	Gene	proliferation|compound|START_ENTITY proliferation|amod|END_ENTITY	IL-15 induces alloreactive CD28 -LRB- - -RRB- memory CD8 T cell proliferation and CTLA4-Ig resistant memory CD8 T cell activation .
25013781	0	CD8	54,57	CD28	34,38	CD8	CD28	925	940	Gene	Gene	cells|nummod|START_ENTITY circulating|dobj|cells END_ENTITY|acl|circulating	Changes of costimulatory molecule CD28 on circulating CD8 + T cells correlate with disease pathogenesis of chronic hepatitis_B .
25241914	0	CD8	8,11	CD28	0,4	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD28 CD8 T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes .
26277688	0	CD8	41,44	CD28	80,84	CD8	CD28	925	940	Gene	Gene	T-lymphocytes|compound|START_ENTITY subpopulations|nmod|T-lymphocytes identified|nsubj|subpopulations identified|nmod|END_ENTITY	Aging-associated subpopulations of human CD8 + T-lymphocytes identified by their CD28 and CD57 phenotypes .
7539725	0	CD8	118,121	CD28	94,98	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY down-regulation|nmod|cells down-regulation|nummod|END_ENTITY	Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8 + T cells from HIV-infected subjects .
7697540	0	CD8	31,34	CD28	25,29	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY Alterations|parataxis|+ Alterations|nmod|levels levels|nmod|END_ENTITY	Alterations in levels of CD28 - / CD8 + suppressor cell precursor and CD45RO + / CD4 + memory T lymphocytes in the peripheral blood of multiple_sclerosis patients .
7973455	0	CD8	22,25	CD28	14,18	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Expression of CD28 on CD8 + and CD4 + lymphocytes during HIV_infection .
8294878	0	CD8	26,29	CD28	135,139	CD8	CD28	925	940	Gene	Gene	thymocytes|compound|START_ENTITY selection|nmod|thymocytes requires|nsubj|selection requires|dobj|signal signal|acl:relcl|provided provided|nmod|END_ENTITY	Negative selection of CD4 + CD8 + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 .
8621891	0	CD8	120,123	CD28	115,119	CD8	CD28	925	940	Gene	Gene	counterparts|compound|START_ENTITY counterparts|compound|END_ENTITY	Shortened_telomeres in clonally expanded CD28-CD8 + T cells imply a replicative history that is distinct from their CD28 + CD8 + counterparts .
8693288	0	CD8	41,44	CD28	65,69	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells activation|dep|role role|nmod|costimulation costimulation|compound|END_ENTITY	T helper-independent activation of human CD8 + cells : the role of CD28 costimulation .
8834463	5	CD8	863,866	CD28	867,871	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY ratio|nummod|+ ratio|compound|END_ENTITY	The strong correlation between the CD4 + / CD8 + ratio and the CD8 + CD28 + / CD8 + CD28 - ratio suggests either a role for CD4 + cells in controlling the CD28 + phenotype or a role for CD8 + CD28 - cells in the decline of CD4 + lymphocytes .
8881750	0	CD8	33,36	CD28	134,138	CD8	CD28	925	940	Gene	Gene	apoptosis|compound|START_ENTITY influence|dobj|apoptosis Factors|acl:relcl|influence Factors|dep|loss loss|nmod|maintenance maintenance|amod|molecules molecules|dep|END_ENTITY	Factors that influence activated CD8 + T-cell apoptosis in patients with acute_herpesvirus_infections : loss of costimulatory molecules CD28 , CD5 and CD6 but relative maintenance of Bax and Bcl-X expression .
9029089	0	CD8	42,45	CD28	14,18	CD8	CD28	925	940	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells costimulation|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CD28 costimulation in human CD8 + T cells .
9067514	0	CD8	0,3	CD28	54,58	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ hyporesponsive|nsubj|cells hyporesponsive|nmod|activation activation|amod|END_ENTITY	CD8 + cells and not CD4 + T cells are hyporesponsive to CD28 - and CD40L-mediated activation in HIV-infected subjects .
9067531	0	CD8	17,20	CD28	87,91	CD8	CD28	925	940	Gene	Gene	pool|compound|START_ENTITY Anomalies|nmod|pool Anomalies|dep|expansions expansions|nmod|END_ENTITY	Anomalies of the CD8 + T cell pool in haemochromatosis : HLA-A3-linked expansions of CD8 + CD28 - T cells .
9075840	0	CD8	145,148	CD28	122,126	CD8	CD28	925	940	Gene	Gene	compartment|compound|START_ENTITY cells|nmod|compartment response|dep|cells response|dep|mobilization mobilization|nmod|+ +|appos|cells cells|nmod|expansion expansion|nmod|CD57 CD57|nummod|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9075840	0	CD8	145,148	CD28	83,87	CD8	CD28	925	940	Gene	Gene	compartment|compound|START_ENTITY cells|nmod|compartment response|dep|cells response|dep|mobilization mobilization|nmod|+ +|appos|cells cells|nummod|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9366442	0	CD8	29,32	CD28	0,4	CD8	CD28	925	940	Gene	Gene	suppression|compound|START_ENTITY increases|dobj|suppression increases|nsubj|costimulation costimulation|compound|END_ENTITY	CD28 costimulation increases CD8 + cell suppression of HIV replication .
9382889	0	CD8	52,55	CD28	130,134	CD8	CD28	925	940	Gene	Gene	thymocytes|compound|START_ENTITY death|nmod|thymocytes death|nmod|mechanisms mechanisms|acl|differing differing|nmod|requirement requirement|nmod|costimulation costimulation|compound|END_ENTITY	T cell receptor -LRB- TCR -RRB- - induced death of immature CD4 + CD8 + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation : implications for negative selection in the thymus .
9421475	0	CD8	22,25	CD28	26,30	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Contribution of CD4 + , CD8 + CD28 + , and CD8 + CD28 - T cells to CD3 + lymphocyte homeostasis during the natural course of HIV-1_infection .
9472663	0	CD8	18,21	CD28	183,187	CD8	CD28	925	940	Gene	Gene	lymphocytes|nummod|START_ENTITY defect|nmod|lymphocytes defect|dep|abnormalities abnormalities|nmod|production production|nmod|interferon-gamma interferon-gamma|nmod|+ +|compound|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9472663	0	CD8	228,231	CD28	183,187	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY defect|dep|+ defect|dep|abnormalities abnormalities|nmod|production production|nmod|interferon-gamma interferon-gamma|nmod|+ +|compound|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9603481	0	CD8	55,58	CD28	59,63	CD8	CD28	925	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Demonstration of identical expanded clones within both CD8 + CD28 + and CD8 + CD28 - T cell subsets in HIV_type_1-infected individuals .
1722959	0	CD8	0,3	CD29	61,65	CD8	CD29	925	3688	Gene	Gene	lymphocytes|nsubj|START_ENTITY lymphocytes|parataxis|expanded expanded|nsubjpass|population population|compound|END_ENTITY	CD8 lymphocytes during Epstein_Barr_virus _ -LRB- EBV -RRB- infection : A CD29 positive population is expanded in acute infectious_mononucleosis .
8343185	0	CD8	71,74	CD29	77,81	CD8	CD29	925	3688	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Presence of estrogen-binding sites on macrophage-like synoviocytes and CD8 + , CD29 + , CD45RO + T lymphocytes in normal and rheumatoid_synovium .
9175023	0	CD8	36,39	CD29	20,24	CD8	CD29	925	3688	Gene	Gene	+|compound|START_ENTITY density|nmod|+ density|compound|END_ENTITY	Correlation between CD29 density on CD8 + lymphocytes and serum IgG in systemic_lupus_erythematosus .
15031541	4	CD8	541,544	CD3	529,532	CD8	CD3	428800(Tax:9031)	396518(Tax:9031)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The percentage of CD3 -LRB- + -RRB- cells , CD4 -LRB- + -RRB- cells , CD8_alpha -LRB- + -RRB- cells , CD8_beta -LRB- + -RRB- , and CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells was 76 % , 41 % , 14 % , 5 % , and 15 % , respectively .
18483926	5	CD8	673,676	CD3	661,664	CD3	CD8	396518(Tax:9031)	403158(Tax:9031)	Gene	Gene	T-cells|amod|START_ENTITY CD4|dep|T-cells CD4|compound|END_ENTITY	In CD4 -LRB- + -RRB- T-cell-deficient chickens , the phenotypes were CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- Vss1-alphassTCR -LRB- + -RRB- T-cells and CD3 -LRB- - -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells .
24297179	0	CD8	115,118	CD3	105,108	CD8	CD3	925	12501(Tax:10090)	Gene	Gene	cAMP_responsive_element_modulator|dep|START_ENTITY cAMP_responsive_element_modulator|nmod|CD8 CD8|nmod|generation generation|nmod|CD4 CD4|compound|END_ENTITY	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
24297179	0	CD8	76,79	CD3	105,108	CD8	CD3	925	12501(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|CD4 CD4|compound|END_ENTITY	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
2972326	0	CD8	66,69	CD3	60,63	CD8	CD3	925	12501(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	In vitro inhibition of normal human hematopoiesis by marrow CD3 + , CD8 + , HLA-DR + , HNK1 + lymphocytes .
10192335	0	CD8	73,76	CD30	19,23	CD8	CD30	925	943	Gene	Gene	cells|compound|START_ENTITY mediated|nmod|cells autoimmune_diabetes|acl|mediated protects|nmod|autoimmune_diabetes protects|csubj|Signalling Signalling|nmod|END_ENTITY	Signalling through CD30 protects against autoimmune_diabetes mediated by CD8 T cells .
11555396	0	CD8	56,59	CD30	90,94	CD8	CD30	925	943	Gene	Gene	clone|compound|START_ENTITY mechanisms|nmod|clone Segregation|nmod|mechanisms correlates|nsubj|Segregation correlates|nmod|expression expression|compound|END_ENTITY	Segregation of effector mechanisms in a tumour-specific CD8 + T-cell clone correlates with CD30 expression .
11756778	0	CD8	42,45	CD30	48,52	CD8	CD30	925	943	Gene	Gene	+|compound|START_ENTITY Epstein-Barr_virus-associated|appos|+ Epstein-Barr_virus-associated|appos|+ +|compound|END_ENTITY	Aggressive Epstein-Barr_virus-associated , CD8 + , CD30 + , CD56 + , surface CD3 - , natural killer -LRB- NK -RRB- - like cytotoxic T-cell_lymphoma .
15280854	0	CD8	27,30	CD30	55,59	CD8	CD30	925	943	Gene	Gene	CD4|compound|START_ENTITY CD4|dep|lymphoproliferative_disorder lymphoproliferative_disorder|compound|END_ENTITY	Progressive epidermotropic CD8 + / CD4 - primary cutaneous CD30 + lymphoproliferative_disorder in a patient with sarcoidosis .
17673391	0	CD8	44,47	CD30	79,83	CD8	CD30	925	943	Gene	Gene	T-cell_lymphoma|compound|START_ENTITY T-cell_lymphoma|nmod|END_ENTITY	Primary cutaneous aggressive epidermotropic CD8 + T-cell_lymphoma with a CD15 -LRB- + -RRB- CD30 -LRB- - -RRB- phenotype .
26288406	0	CD8	18,21	CD30	25,29	CD8	CD30	925	943	Gene	Gene	START_ENTITY|dep|Anaplastic_Large_Cell_Lymphoma Anaplastic_Large_Cell_Lymphoma|compound|END_ENTITY	Primary Cutaneous CD8 -LRB- + -RRB- CD30 -LRB- + -RRB- Anaplastic_Large_Cell_Lymphoma : An Unusual Case with a High Ki-67 index-A Short Review .
26485239	0	CD8	38,41	CD30	43,47	CD8	CD30	925	943	Gene	Gene	+|compound|START_ENTITY Characterization|nmod|+ Characterization|parataxis|Disorders Disorders|nsubj|Lymphoproliferative Lymphoproliferative|compound|END_ENTITY	Characterization of Primary Cutaneous CD8 + / CD30 + Lymphoproliferative Disorders .
7964515	0	CD8	19,22	CD30	0,4	CD8	CD30	925	943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD30 expression by CD8 + T cells producing type 2 helper cytokines .
7964515	1	CD8	97,100	CD30	101,105	CD8	CD30	925	943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Evidence for large numbers of CD8 + CD30 + T cell clones in human_immunodeficiency_virus_infection .
8871616	0	CD8	25,28	CD30	0,4	CD8	CD30	925	943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD30 expression on human CD8 + T cells isolated from peripheral blood lymphocytes of normal donors .
22077960	0	CD8	18,21	CD300a	11,17	CD8	CD300a	925	11314	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripheral CD300a + CD8 + T lymphocytes with a distinct cytotoxic molecular signature increase in pregnant women with chronic chorioamnionitis .
12055215	0	CD8	36,39	CD36	0,4	CD8	CD36	925	948	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	CD36 is differentially expressed by CD8 + splenic dendritic cells but is not required for cross-presentation in vivo .
10861690	0	CD8	90,93	CD38	82,86	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Multisite comparison of methods for the quantitation of the surface expression of CD38 on CD8 -LRB- + -RRB- T lymphocytes .
12032270	0	CD8	19,22	CD38	0,4	CD8	CD38	925	952	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	CD38 expression on CD8 -LRB- + -RRB- T cells as a prognostic marker in vertically HIV-infected pediatric patients .
12882659	0	CD8	14,17	CD38	64,68	CD8	CD38	925	952	Gene	Gene	nonlytic|compound|START_ENTITY Production|nmod|nonlytic suppressive|nsubj|Production suppressive|nmod|CD28 CD28|nummod|END_ENTITY	Production of CD8 + T cell nonlytic suppressive factors by CD28 , CD38 , and HLA-DR subpopulations .
12930365	0	CD8	46,49	CD38	21,25	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY molecules|nmod|T molecules|nummod|END_ENTITY	Increased numbers of CD38 molecules on bright CD8 + T lymphocytes in infectious_mononucleosis caused by Epstein-Barr_virus infection .
12959688	0	CD8	88,91	CD38	80,84	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Distribution of naive and memory/effector CD4 + T lymphocytes and expression of CD38 on CD8 + T lymphocytes in AIDS patients with tuberculosis .
14727214	0	CD8	19,22	CD38	0,4	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD38 expression in CD8 + T cells predicts virological failure_in_HIV_type_1-infected children receiving antiretroviral therapy .
14983032	0	CD8	86,89	CD38	81,85	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Relationship between the frequency of HIV-specific CD8 + T cells and the level of CD38 + CD8 + T cells in untreated HIV-infected individuals .
14983032	7	CD8	1216,1219	CD38	1211,1215	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The distribution of HIV-specific CD8 + T cells was heavily skewed toward CD38 + CD8 + T cells in patients with a high percentage of CD38 + CD8 + T cells .
15018711	0	CD8	19,22	CD38	0,4	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	CD38 expression on CD8 T lymphocytes as a marker of residual virus replication in chronically HIV-infected patients receiving antiretroviral therapy .
15117448	0	CD8	0,3	CD38	4,8	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD38 + T cells but not HIV_type_1 RNA viral load predict CD4 + T cell loss in a predominantly minority female HIV + adolescent population .
18257774	0	CD8	19,22	CD38	0,4	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy .
18784457	0	CD8	5,8	CD38	0,4	CD8	CD38	925	952	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	CD38 + CD8 + T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals .
19072838	0	CD8	21,24	CD38	26,30	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY association|nmod|+ association|dep|END_ENTITY	Close association of CD8 + / CD38 bright with HIV-1 replication and complex relationship with CD4 + T-cell count .
20017809	0	CD8	32,35	CD38	13,17	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Relevance of CD38 expression on CD8 T cells to evaluate antiretroviral therapy response in HIV-1-infected youths .
21429312	0	CD8	34,37	CD38	15,19	CD8	CD38	925	952	Gene	Gene	cells|nummod|START_ENTITY Expression|nmod|cells Expression|nmod|END_ENTITY	-LSB- Expression of CD38 and HLA-DR on CD8 + T cells in pediatric AIDS patients receiving highly active antiretroviral therapy -LRB- HAART -RRB- -RSB- .
21980834	0	CD8	31,34	CD38	11,15	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY measurement|nmod|T measurement|compound|END_ENTITY	Discordant CD38 measurement of CD8 + T lymphocytes using fluorescein conjugates in comparison with phycoerythrin conjugates .
23028866	0	CD8	57,60	CD38	17,21	CD8	CD38	925	12494(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY demarcates|dobj|cells demarcates|nsubj|END_ENTITY	Ectonucleotidase CD38 demarcates regulatory , memory-like CD8 + T cells with IFN-y-mediated suppressor activities .
24587800	0	CD8	9,12	CD38	88,92	CD8	CD38	925	952	Gene	Gene	Activation|compound|START_ENTITY Level|nmod|Activation Level|parataxis|Markers Markers|nmod|Context Context|nmod|END_ENTITY	Level of CD8 T Lymphocytes Activation in HIV-Infected Pregnant Women : In the Context of CD38 and HLA-DR Activation Markers .
25000587	0	CD8	46,49	CD38	32,36	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY role|parataxis|T role|nmod|END_ENTITY	Potential role for HIV-specific CD38 - / HLA-DR + CD8 + T cells in viral suppression and cytotoxicity in HIV controllers .
26289091	0	CD8	28,31	CD38	87,91	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY Dysfunction|nmod|T correlates|nsubj|Dysfunction correlates|nmod|expression expression|compound|END_ENTITY	Dysfunction of PSA-specific CD8 -LRB- + -RRB- T cells in prostate_cancer patients correlates with CD38 and Tim-3 expression .
26289091	0	CD8	28,31	CD38	87,91	CD8	CD38	925	952	Gene	Gene	T|compound|START_ENTITY Dysfunction|nmod|T correlates|nsubj|Dysfunction correlates|nmod|expression expression|compound|END_ENTITY	Dysfunction of PSA-specific CD8 -LRB- + -RRB- T cells in prostate_cancer patients correlates with CD38 and Tim-3 expression .
26586704	0	CD8	104,107	CD38	80,84	CD8	CD38	925	952	Gene	Gene	Lymphocytes|compound|START_ENTITY Associated|nmod|Lymphocytes Associated|nmod|Expression Expression|nmod|Perforin Perforin|nummod|END_ENTITY	Advanced Lung_Cancer Is Associated with Decreased Expression of Perforin , CD95 , CD38 by Circulating CD3 + CD8 + T Lymphocytes .
27100997	0	CD8	5,8	CD38	0,4	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD38 + CD8 + and CD38 + CD4 + T Cells and IFN_Gamma -LRB- +874 -RRB- Polymorphism Are Associated with a Poor Virological Outcome .
7545096	0	CD8	126,129	CD38	205,209	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY increased|dobj|+ increased|nmod|molecules molecules|appos|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7545096	0	CD8	245,248	CD38	205,209	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY molecules|appos|+ molecules|appos|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7686224	0	CD8	25,28	CD38	19,23	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated levels of CD38 + CD8 + T cells in HIV_infection add to the prognostic value of low CD4 + T cell levels : results of 6 years of follow-up .
7688270	0	CD8	0,3	CD38	4,8	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD8 + CD38 + and CD8 + DR + peripheral blood_lymphoid_subsets_of_HIV-infected intravenous drug abusers correlate with CD4 + cell counts and proliferation to mitogens .
7930717	0	CD8	0,3	CD38	105,109	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY lymphocyte|nsubj|+ lymphocyte|dobj|activation activation|dep|development development|nmod|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
7930717	0	CD8	111,114	CD38	105,109	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY associated|nsubjpass|cells lymphocyte|parataxis|associated lymphocyte|dobj|activation activation|dep|development development|nmod|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
8454874	0	CD8	25,28	CD38	56,60	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|antigens antigens|compound|END_ENTITY	Circulating HIV-specific CD8 + cytotoxic T cells express CD38 and HLA-DR antigens .
8809474	0	CD8	71,74	CD38	44,48	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Elevated relative fluorescence intensity of CD38 antigen expression on CD8 + T cells is a marker of poor prognosis in HIV_infection : results of 6 years of follow-up .
8828739	0	CD8	38,41	CD38	42,46	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased numbers of primed activated CD8 + CD38 + CD45RO + T cells predict the decline of CD4 + T cells in HIV-1-infected patients .
9083895	0	CD8	87,90	CD38	91,95	CD8	CD38	925	952	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8 + CD95 + , CD8 + CD38 + , and CD4 + CD95 + T cells are markers for HIV-1_infection and clinical status .
9358102	0	CD8	36,39	CD38	9,13	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Elevated CD38 antigen expression on CD8 + T cells is a stronger marker for the risk of chronic HIV_disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4 + cell count , soluble immune activation markers , or combinations of HLA-DR and CD38 expression .
9458031	0	CD8	48,51	CD38	52,56	CD8	CD38	925	952	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Monitoring of cytomegalovirus infections by the CD8 + CD38 + T-cell subset in kidney transplant recipients .
9773872	0	CD8	54,57	CD38	16,20	CD8	CD38	925	952	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9773873	0	CD8	33,36	CD38	0,4	CD8	CD38	925	952	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD38 expression on cryopreserved CD8 + T cells predicts HIV_disease_progression .
23359087	0	CD8	84,87	CD39	0,4	CD8	CD39	925	953	Gene	Gene	lymphocytes|compound|START_ENTITY activity|nmod|lymphocytes mediating|dobj|activity involved|advcl|mediating involved|nsubjpass|END_ENTITY	CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8 + T regulatory lymphocytes .
23606272	0	CD8	85,88	CD39	0,4	CD8	CD39	925	953	Gene	Gene	CD39|compound|START_ENTITY bovis|dobj|CD39 bovis|dep|involved involved|nsubjpass|END_ENTITY	CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8 -LRB- + -RRB- CD39 -LRB- + -RRB- regulatory T cells .
26485519	0	CD8	48,51	CD39	0,4	CD8	CD39	925	953	Gene	Gene	Cells|compound|START_ENTITY Identifies|dobj|Cells Identifies|nsubj|Expression Expression|compound|END_ENTITY	CD39 Expression Identifies Terminally Exhausted CD8 + T Cells .
26549640	0	CD8	42,45	CD39	23,27	CD8	CD39	925	953	Gene	Gene	T|compound|START_ENTITY NADH|nmod|T NADH|dobj|expression expression|compound|END_ENTITY	NADH oxidase-dependent CD39 expression by CD8 -LRB- + -RRB- T cells modulates interferon_gamma responses via generation of adenosine .
26823801	0	CD8	48,51	CD39	40,44	CD8	CD39	925	953	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Overexpression of CD39 and high tumoral CD39 -LRB- + -RRB- / CD8 -LRB- + -RRB- ratio are associated with adverse prognosis in resectable gastric_cancer .
10064055	0	CD8	49,52	CD4	44,47	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Spontaneous clustering of Thy-1 antigens on CD4 + CD8 + thymocytes lacking TCR engagement by MHC/peptide complexes .
10190907	0	CD8	120,123	CD4	152,155	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY cytotoxicity|nmod|T cells|amod|cytotoxicity independently|nmod:npmod|cells independently|nmod|T T|compound|END_ENTITY	Cytotoxic T lymphocyte-associated antigen 4 -LRB- CTLA-4 -RRB- can regulate dendritic cell-induced activation and cytotoxicity of CD8 -LRB- + -RRB- T cells independently of CD4 -LRB- + -RRB- T cell help .
10203105	0	CD8	31,34	CD4	26,29	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY proliferation|dep|cells proliferation|nmod|END_ENTITY	Abnormal proliferation of CD4 - CD8 + gammadelta + T cells with chromosome 6 anomaly : role of Fas_ligand expression in spontaneous regression of the cells .
10206260	0	CD8	54,57	CD4	89,92	CD8	CD4	925	920	Gene	Gene	molecules|nummod|START_ENTITY molecules|nmod|lymphocyte lymphocyte|amod|alternative alternative|nmod|+ +|compound|END_ENTITY	Evaluation of a quantitative determination of CD4 and CD8 molecules as an alternative to CD4 + and CD8 + T lymphocyte counts in Africans .
10370378	0	CD8	52,55	CD4	48,51	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Effects of SIVmac_infection on peripheral blood CD4 + CD8 + T lymphocytes in cynomolgus macaques .
10380839	0	CD8	26,29	CD4	21,24	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY Relationship|dep|ratio Relationship|nmod|+ +|compound|END_ENTITY	Relationship between CD4 + / CD8 + T cell ratio and T cell activation in systemic_lupus_erythematosus .
10400821	6	CD8	1231,1234	CD4	1226,1229	CD8	CD4	925	920	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	Drug-induced clearance of parasitemia was characterized by a decrease of IL-2 + / IFN-gamma - and type 2 cytokine expressing CD4 - / CD8 - cells and by a gradual increase of IL-10 + / IFN-gamma - expression .
10477611	0	CD8	41,44	CD4	16,19	CD8	CD4	925	920	Gene	Gene	activation|compound|START_ENTITY cells|nmod|activation cells|nummod|END_ENTITY	Requirement for CD4 + T cells in V beta 4 + CD8 + T cell activation associated with latent murine gammaherpesvirus infection .
10510084	0	CD8	93,96	CD4	87,90	CD8	CD4	925	920	Gene	Gene	thymocytes|amod|START_ENTITY thymocytes|amod|END_ENTITY	Receptor avidity and costimulation specify the intracellular Ca2 + signaling pattern in CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes .
10549630	0	CD8	25,28	CD4	61,64	CD8	CD4	925	920	Gene	Gene	tolerance|compound|START_ENTITY reverses|dobj|tolerance reverses|nmod|cell cell|compound|END_ENTITY	CTLA-4 blockade reverses CD8 + T cell tolerance to tumor by a CD4 + T cell - and IL-2-dependent mechanism .
10599998	0	CD8	94,97	CD4	18,21	CD8	CD4	925	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing appearance|nmod|cells leads|nmod|appearance leads|nsubj|Co-cultivation Co-cultivation|nmod|+ +|compound|END_ENTITY	Co-cultivation of CD4 + and CD8 + human T-cells leads to the appearance of CD4 cells expressing CD8 through de novo synthesis of the CD8_alpha-subunit .
10599998	0	CD8	94,97	CD4	73,76	CD8	CD4	925	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|nummod|END_ENTITY	Co-cultivation of CD4 + and CD8 + human T-cells leads to the appearance of CD4 cells expressing CD8 through de novo synthesis of the CD8_alpha-subunit .
10640739	0	CD8	104,107	CD4	100,103	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	CD5 costimulation up-regulates the signaling to extracellular_signal-regulated_kinase activation in CD4 + CD8 + thymocytes and supports their differentiation to the CD4 lineage .
10640771	0	CD8	207,210	CD4	14,17	CD8	CD4	925	920	Gene	Gene	epitope|compound|START_ENTITY overlap|nmod|epitope overlap|dep|60 60|dep|response response|compound|END_ENTITY	Multispecific CD4 + T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia_enterocolitica in Yersinia-triggered reactive_arthritis : overlap with the B27-restricted CD8 epitope , functional properties , and epitope presentation by multiple DR alleles .
10713333	0	CD8	12,15	CD4	8,11	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Unusual CD4 + CD8 + phenotype in a greek patient diagnosed with adult_T-cell_leukemia positive for human_T-cell_leukemia_virus_type_I _ -LRB- HTLV-I -RRB- .
10743519	0	CD8	12,15	CD4	8,11	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY Role|dep|ratio Role|nmod|END_ENTITY	Role of CD4 : CD8 ratio in predicting HIV_co-infection in patients with newly diagnosed tuberculosis .
10761920	0	CD8	67,70	CD4	55,58	CD8	CD4	925	920	Gene	Gene	fate|compound|START_ENTITY +|nmod|fate +|compound|END_ENTITY	The duration of antigen receptor signalling determines CD4 + versus CD8 + T-cell lineage fate .
10798745	0	CD8	59,62	CD4	26,29	CD8	CD4	925	920	Gene	Gene	CD28|compound|START_ENTITY Induction|nmod|CD28 Induction|nmod|anergy anergy|compound|END_ENTITY	Induction of xenoreactive CD4 + T-cell anergy by suppressor CD8 + CD28 - T cells .
10805728	0	CD8	0,3	CD4	38,41	CD8	CD4	925	920	Gene	Gene	extinction|compound|START_ENTITY extinction|nmod|CD8 CD8|compound|END_ENTITY	CD8 coreceptor extinction in signaled CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes : coordinate roles for both transcriptional and posttranscriptional regulatory mechanisms in developing thymocytes .
10864680	0	CD8	51,54	CD4	155,158	CD8	CD4	925	920	Gene	Gene	activity|nmod|START_ENTITY analysis|nmod|activity T|nsubj|analysis T|ccomp|decrease decrease|nsubj|cells cells|nmod|patients patients|nmod|rates rates|nmod|T-cell T-cell|compound|END_ENTITY	Quantitative analysis of the antiviral activity of CD8 -LRB- + -RRB- T cells from human immunodeficiency virus-positive asymptomatic patients with different rates of CD4 -LRB- + -RRB- T-cell decrease .
10882415	0	CD8	92,95	CD4	70,73	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY extinction|nmod|T extinction|nummod|END_ENTITY	Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8 -LRB- + -RRB- T cell differentiation in the thymus .
10899249	0	CD8	19,22	CD4	15,18	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY Correlation|dep|ratio Correlation|nmod|END_ENTITY	Correlation of CD4 : CD8 ratio and tumour necrosis factor -LRB- TNF -RRB- alpha levels in induced sputum with bronchoalveolar lavage fluid in pulmonary_sarcoidosis .
10933395	0	CD8	131,134	CD4	44,47	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY differentiating|nmod|cells terminate|advcl|differentiating terminate|nsubj|thymocytes thymocytes|nummod|+8 +8|compound|END_ENTITY	Coreceptor reversal in the thymus : signaled CD4 +8 + thymocytes initially terminate CD8 transcription even when differentiating into CD8 + T cells .
10933395	0	CD8	82,85	CD4	44,47	CD8	CD4	925	920	Gene	Gene	transcription|compound|START_ENTITY terminate|dobj|transcription terminate|nsubj|thymocytes thymocytes|nummod|+8 +8|compound|END_ENTITY	Coreceptor reversal in the thymus : signaled CD4 +8 + thymocytes initially terminate CD8 transcription even when differentiating into CD8 + T cells .
10942090	0	CD8	16,19	CD4	11,14	CD8	CD4	925	920	Gene	Gene	counts|compound|START_ENTITY estimated|nsubj|counts +|parataxis|estimated +|compound|END_ENTITY	Peripheral CD4 + / CD8 + T-lymphocyte counts estimated by an immunocapture method in the normal healthy south Indian adults and HIV seropositive individuals .
11026443	0	CD8	31,34	CD4	26,29	CD8	CD4	925	920	Gene	Gene	remission|dep|START_ENTITY Normalization|dep|remission Normalization|nmod|END_ENTITY	Normalization of elevated CD4 - / CD8 - -LRB- double-negative -RRB- T cells after thymectomy parallels clinical remission in myasthenia_gravis associated with thymic_hyperplasia but not thymoma .
11067895	0	CD8	13,16	CD4	9,12	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Immature CD4 + CD8 + thymocytes do not polarize lipid rafts in response to TCR-mediated signals .
11119431	0	CD8	52,55	CD4	48,51	CD8	CD4	925	920	Gene	Gene	normalization|nummod|START_ENTITY Characteristics|dep|normalization Characteristics|nmod|patients patients|nmod|END_ENTITY	Characteristics of HIV-1-infected patients with CD4 : CD8 lymphocyte ratio normalization on antiretroviral therapy .
11206348	0	CD8	38,41	CD4	33,36	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Distribution of double-negative -LRB- CD4 - CD8 - , DN -RRB- T subsets in blood and synovial_fluid from patients with rheumatoid_arthritis .
11292262	0	CD8	16,19	CD4	12,15	CD8	CD4	925	920	Gene	Gene	stage|nummod|START_ENTITY +|dobj|stage END_ENTITY|acl|+	The `` early ' CD4 + CD8 + stage of thymocte differentiation hallmarks the end of a strong positive correlation between extracellular matrix receptor expression and protein tyrosine phosphorylation .
11292726	0	CD8	23,26	CD4	16,19	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Reversal of the CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T-cell ratio in lymph node cells upon in vitro mitogenic stimulation by highly purified , water-soluble S3-S4 dimer of pertussis toxin .
11303820	0	CD8	158,161	CD4	132,135	CD8	CD4	925	920	Gene	Gene	+|nummod|START_ENTITY low|dep|+ eradication|advmod|low eradication|nmod|increase increase|nmod|count count|compound|END_ENTITY	Visceral_leishmaniasis in an AIDS patient on successful antiretroviral therapy : failure of parasite eradication despite increase in CD4 + T-cell count but low CD8 + T-cell count .
11342604	0	CD8	62,65	CD4	58,61	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Distinct mechanisms contribute to generate and change the CD4 : CD8 cell ratio during thymus development : a role for the Notch ligand , Jagged1 .
11389959	0	CD8	34,37	CD4	30,33	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Comparative evaluation of the CD4 + CD8 + and CD4 + CD8 - lymphocytes in the immune response to porcine_rubulavirus .
11422033	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + CD8 + -LRB- thymocyte-like -RRB- T lymphocytes present in blood and skin from patients with atopic_dermatitis suggest immune_dysregulation .
11454056	0	CD8	23,26	CD4	16,19	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY Upregulation|nmod|cells Upregulation|nmod|END_ENTITY	Upregulation of CD4 on CD8 + T cells : CD4dimCD8bright T cells constitute an activated phenotype of CD8 + T cells .
11454056	0	CD8	98,101	CD4	16,19	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY phenotype|nmod|cells constitute|dobj|phenotype Upregulation|parataxis|constitute Upregulation|nmod|END_ENTITY	Upregulation of CD4 on CD8 + T cells : CD4dimCD8bright T cells constitute an activated phenotype of CD8 + T cells .
11466326	0	CD8	25,28	CD4	51,54	CD8	CD4	925	920	Gene	Gene	activation|compound|START_ENTITY control|nmod|activation control|nmod|cells cells|compound|END_ENTITY	Cutting edge : control of CD8 + T cell activation by CD4 + CD25 + immunoregulatory cells .
11466356	0	CD8	104,107	CD4	50,53	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY requires|nmod|cells requires|nsubj|function function|nmod|cells cells|compound|END_ENTITY	Antibody-independent antiviral function of memory CD4 + T cells in vivo requires regulatory signals from CD8 + effector T cells .
11477541	0	CD8	6,9	CD4	0,3	CD8	CD4	925	920	Gene	Gene	TCR|compound|START_ENTITY thymocytes|nsubj|TCR thymocytes|nsubj|END_ENTITY	CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- TCR -LRB- low -RRB- thymocytes express low levels of glucocorticoid_receptors while being sensitive to glucocorticoid-induced apoptosis .
11479623	0	CD8	71,74	CD4	90,93	CD8	CD4	925	920	Gene	Gene	stable|dep|START_ENTITY END_ENTITY|amod|stable	Differential regulation of antiviral T-cell immunity results in stable CD8 + but declining CD4 + T-cell memory .
11485408	0	CD8	167,170	CD4	133,136	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY independence|nmod|T independence|compound|T T|compound|END_ENTITY	Viral neuraminidase treatment of dendritic cells enhances antigen-specific CD8 -LRB- + -RRB- T cell proliferation , but does not account for the CD4 -LRB- + -RRB- T cell independence of the CD8 -LRB- + -RRB- T cell response during influenza_virus_infection .
11526203	0	CD8	37,40	CD4	13,16	CD8	CD4	925	920	Gene	Gene	type|nsubj|START_ENTITY T|ccomp|type T|nsubj|Induction Induction|nmod|END_ENTITY	Induction of CD4 -LRB- + -RRB- T cell-dependent CD8 -LRB- + -RRB- type 1 responses in humans by a malaria DNA vaccine .
11589307	0	CD8	69,72	CD4	65,68	CD8	CD4	925	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Downregulated expression of Ly-6-ThB on developing T cells marks CD4 + CD8 + subset undergoing selection in the thymus .
11594915	0	CD8	35,38	CD4	23,26	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|amod|bright bright|dep|END_ENTITY	Increase in peripheral CD4 bright + CD8 dull + T cells in Parkinson_disease .
11689637	0	CD8	21,24	CD4	45,48	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY express|nsubj|lymphocytes express|dobj|END_ENTITY	Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human_immunodeficiency_virus_type_1 .
11756173	0	CD8	14,17	CD4	48,51	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY Activation|nmod|cells induces|nsubj|Activation induces|dobj|expression expression|nmod|END_ENTITY	Activation of CD8 T cells induces expression of CD4 , which functions as a chemotactic receptor .
11757730	0	CD8	32,35	CD4	15,18	CD8	CD4	925	920	Gene	Gene	Association|parataxis|START_ENTITY Association|nmod|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
11821901	0	CD8	62,65	CD4	15,18	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY development|nmod|responses crucial|nmod|development crucial|nsubj|cells cells|compound|END_ENTITY	IL-4-secreting CD4 + T cells are crucial to the development of CD8 + T-cell responses against malaria liver stages .
11823493	0	CD8	113,116	CD4	76,79	CD8	CD4	925	920	Gene	Gene	required|nmod|START_ENTITY required|nmod|development development|nmod|thymocytes thymocytes|amod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11823493	0	CD8	82,85	CD4	107,110	CD8	CD4	925	920	Gene	Gene	thymocytes|amod|START_ENTITY development|nmod|thymocytes required|nmod|development required|nmod|CD8 CD8|compound|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11823493	0	CD8	82,85	CD4	76,79	CD8	CD4	925	920	Gene	Gene	thymocytes|amod|START_ENTITY thymocytes|amod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11867562	0	CD8	11,14	CD4	106,109	CD8	CD4	925	920	Gene	Gene	expression|compound|START_ENTITY expression|acl|induced induced|nmod|cytokines cytokines|nmod|END_ENTITY	Reversible CD8 expression induced by common_cytokine_receptor_gamma_chain-dependent cytokines in a cloned CD4 -LRB- + -RRB- T -LRB- h -RRB- 1 cell line .
11937530	0	CD8	89,92	CD4	31,34	CD8	CD4	925	920	Gene	Gene	activation|compound|START_ENTITY potentiates|dobj|activation activation|dep|potentiates activation|compound|END_ENTITY	In vivo CD86 blockade inhibits CD4 + T cell activation , whereas CD80 blockade potentiates CD8 + T cell activation and CTL effector function .
12023777	0	CD8	133,136	CD4	111,114	CD8	CD4	925	920	Gene	Gene	ratios|compound|START_ENTITY Relationship|dep|ratios Relationship|nmod|size size|nmod|reservoir reservoir|nmod|cells cells|compound|END_ENTITY	Relationship between the size of the human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- reservoir in peripheral blood CD4 + T cells and CD4 + : CD8 + T cell ratios in aviremic_HIV-1-infected individuals receiving long-term highly active antiretroviral therapy .
12067759	0	CD8	21,24	CD4	45,48	CD8	CD4	925	920	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|clone clone|compound|END_ENTITY	Co-expression of the CD8 receptor in a human CD4 + T-cell clone influences proliferation , cytosolic Ca2 + release and cytokine production .
12114403	0	CD8	60,63	CD4	12,15	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells induces|dobj|expansion induces|nsubj|Infusion Infusion|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Infusion of CD4 + donor lymphocytes induces the expansion of CD8 + donor T cells with cytolytic activity directed against recipient hematopoietic cells .
12139944	0	CD8	47,50	CD4	41,44	CD8	CD4	925	920	Gene	Gene	START_ENTITY|nsubj|picture picture|nmod|END_ENTITY	A composite picture of TcR alpha/beta -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T Cells -LRB- alpha/beta-DNTCs -RRB- in humans with autoimmune_lymphoproliferative_syndrome .
12194751	0	CD8	35,38	CD4	27,30	CD8	CD4	925	920	Gene	Gene	T-cells|compound|START_ENTITY +|nmod|T-cells +|nsubj|effect effect|nmod|ratio ratio|nmod|END_ENTITY	The effect of the ratio of CD4 + to CD8 + T-cells on radiation-induced apoptosis in human lymphocyte subpopulations .
12209632	0	CD8	0,3	CD4	31,34	CD8	CD4	925	920	Gene	Gene	lethargy|nummod|START_ENTITY lethargy|nmod|absence absence|nmod|END_ENTITY	CD8 lethargy in the absence of CD4 help .
12366378	0	CD8	47,50	CD4	43,46	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Soluble factor-mediated differentiation of CD4 + CD8 + thymocytes to single positives in vitro .
12421913	0	CD8	85,88	CD4	14,17	CD8	CD4	925	920	Gene	Gene	rejection|compound|START_ENTITY prevent|dobj|rejection cells|acl:relcl|prevent cells|compound|END_ENTITY	Cutting edge : CD4 + CD25 + alloantigen-specific immunoregulatory cells that can prevent CD8 + T cell-mediated graft rejection : implications for anti-CD154 immunotherapy .
12534590	0	CD8	91,94	CD4	30,33	CD8	CD4	925	920	Gene	Gene	activity|nmod|START_ENTITY clone|nmod|activity Isolation|dep|clone Isolation|nmod|END_ENTITY	Isolation of a CD8alphaalpha + CD4 - tumour T-cell clone with cytotoxic activity from a CD4 + CD8 - cutaneous_T-cell_lymphoma .
12594515	0	CD8	64,67	CD4	0,3	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY required|nmod|lymphocytes required|nsubjpass|cells cells|compound|END_ENTITY	CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes .
12626577	0	CD8	134,137	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY associated|nmod|cells associated|nsubjpass|differentiation differentiation|compound|END_ENTITY	CD4 + T cell-induced differentiation of EBV-transformed lymphoblastoid cells is associated with diminished recognition by EBV-specific CD8 + cytotoxic T cells .
12695490	0	CD8	109,112	CD4	22,25	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY lymphoid|nmod|cells lymphoid|nsubj|role role|nmod|T T|compound|END_ENTITY	Complementary role of CD4 + T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8 + T cells .
12782709	0	CD8	113,116	CD4	67,70	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY presentation|nmod|cells help|nmod|presentation help|nummod|END_ENTITY	Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8 + T cells : implications for vaccine development in immune-deficient hosts .
12787722	0	CD8	11,14	CD4	62,65	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY control|nsubj|cells control|dobj|clones clones|compound|END_ENTITY	Regulatory CD8 + T cells control thyrotropin receptor-specific CD4 + clones in healthy subjects .
12791668	0	CD8	0,3	CD4	26,29	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY cells|acl:relcl|express express|dobj|END_ENTITY	CD8 + T cells that express CD4 on their surface -LRB- CD4dimCD8bright T cells -RRB- recognize an antigen-specific target , are detected in vivo , and can be productively infected by T-tropic HIV .
12804002	0	CD8	111,114	CD4	107,110	CD8	CD4	925	920	Gene	Gene	count|compound|START_ENTITY count|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12804002	0	CD8	111,114	CD4	43,46	CD8	CD4	925	920	Gene	Gene	count|compound|START_ENTITY +|nmod|count +|nsubj|immunodeficiency_virus_infection immunodeficiency_virus_infection|nmod|CD8 CD8|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12804002	0	CD8	47,50	CD4	107,110	CD8	CD4	925	920	Gene	Gene	immunodeficiency_virus_infection|nmod|START_ENTITY +|nsubj|immunodeficiency_virus_infection +|nmod|count count|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12810689	0	CD8	173,176	CD4	117,120	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY selection|nmod|cells lo|nmod|selection lo|csubj|Unraveling Unraveling|parataxis|appear appear|nmod|END_ENTITY	Unraveling a revealing paradox : Why major histocompatibility complex I-signaled thymocytes `` paradoxically '' appear as CD4 +8 lo transitional cells during positive selection of CD8 + T cells .
12839958	0	CD8	117,120	CD4	28,31	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY generation|nmod|cells enhance|nmod|generation +|ccomp|enhance END_ENTITY|acl|+	P53 -LRB- 110-124 -RRB- - specific human CD4 + T-helper cells enhance in vitro generation and antitumor function of tumor-reactive CD8 + T cells .
1284651	0	CD8	6,9	CD4	45,48	CD8	CD4	925	920	Gene	Gene	clone|compound|START_ENTITY regulates|nsubj|clone regulates|dobj|autologous autologous|acl:relcl|myelin_basic_protein myelin_basic_protein|nsubj|+ +|compound|END_ENTITY	Human CD8 + T cell clone regulates autologous CD4 + myelin_basic_protein specific T cells .
1321339	0	CD8	46,49	CD4	42,45	CD8	CD4	925	920	Gene	Gene	precursors|compound|START_ENTITY precursors|compound|END_ENTITY	A viral long terminal repeat expressed in CD4 + CD8 + precursors is downregulated in mature peripheral CD4-CD8 + or CD4 + CD8 - T cells .
1347493	0	CD8	96,99	CD4	91,94	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreases in alpha beta T cell receptor negative T cells and CD8 cells , and an increase in CD4 + CD8 + cells in active Hashimoto 's _ disease and subacute_thyroiditis .
1354230	4	CD8	707,710	CD4	703,706	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Furthermore , this decrease in CD4 + CD8 + cells was accompanied by a relative increase in the percentages of CD4 + CD8 - , CD4-CD8 + and CD4-CD8 - cells , whereas their absolute numbers actually reduced on day 4 .
1357752	0	CD8	81,84	CD4	77,80	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Negative selection of precursor thymocytes before their differentiation into CD4 + CD8 + cells .
1363009	0	CD8	42,45	CD4	37,40	CD8	CD4	925	493775(Tax:9685)	Gene	Gene	ratio|nummod|START_ENTITY decrease|dep|ratio decrease|nmod|+ +|compound|END_ENTITY	Immunization-induced decrease of the CD4 + : CD8 + ratio in cats experimentally infected with feline_immunodeficiency_virus .
1375001	0	CD8	106,109	CD4	100,103	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
1387565	0	CD8	105,108	CD4	99,102	CD8	CD4	925	920	Gene	Gene	approach|appos|START_ENTITY approach|acl|understanding understanding|dobj|development development|dep|isolation isolation|nmod|END_ENTITY	A new approach to understanding T cell development : the isolation and characterization of immature CD4 - , CD8 - , CD3 - T cell cDNAs by subtraction cloning .
1387727	0	CD8	51,54	CD4	45,48	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	Expression of CD11b -LRB- Leu15 -RRB- antigen on CD3 + , CD4 + , CD8 + , CD16 + peripheral lymphocytes .
1421412	0	CD8	113,116	CD4	139,142	CD8	CD4	925	920	Gene	Gene	CD4|compound|START_ENTITY mediated|nmod|CD4 mediated|parataxis|thymocytes thymocytes|nsubj|+ +|compound|END_ENTITY	Enhancement of T-cell-depleted bone marrow allografts in the absence of graft-versus-host disease is mediated by CD8 + CD4 - and not by CD8 - CD4 + thymocytes .
1434032	0	CD8	18,21	CD4	14,17	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- Expansion of CD4 + CD8 + T lymphocytes in the peripheral blood of a patient with pulmonary_tuberculosis -RSB- .
14500656	0	CD8	178,181	CD4	137,140	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY thymocytes|nsubj|+ antisense|parataxis|thymocytes antisense|ccomp|reveals reveals|nmod|factor factor|nmod|END_ENTITY	Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4 - / CD8 + thymocytes .
14500656	0	CD8	178,181	CD4	173,176	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY thymocytes|nsubj|+ antisense|parataxis|thymocytes antisense|ccomp|reveals reveals|dep|silencing silencing|nmod|development development|nmod|END_ENTITY	Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4 - / CD8 + thymocytes .
14562607	0	CD8	77,80	CD4	73,76	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Possible role of genetic factor -LRB- s -RRB- on age-related increase of peripheral CD4 + CD8 + double positive T cells in cynomolgus_monkeys .
14605443	0	CD8	11,14	CD4	96,99	CD8	CD4	925	920	Gene	Gene	Ability|nmod|START_ENTITY T|nsubj|Ability T|xcomp|counts counts|nsubj|activity activity|acl|correlated correlated|nmod|T T|compound|END_ENTITY	Ability of CD8 -LRB- + -RRB- T cell anti-feline immunodeficiency virus activity correlated with peripheral CD4 -LRB- + -RRB- T cell counts and plasma_viremia .
14607920	0	CD8	159,162	CD4	118,121	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY priming|nmod|cells T|advcl|priming T|nsubj|+ +|compound|END_ENTITY	Antigenic epitopes fused to cationic peptide bound to oligonucleotides facilitate Toll-like_receptor_9-dependent , but CD4 + T cell help-independent , priming of CD8 + T cells .
14609046	0	CD8	23,26	CD4	17,20	CD8	CD4	925	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	A pilot study on CD4 _ CD8 cell counts in healthy HIV seronegative pregnant women .
14611679	0	CD8	35,38	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY cells|appos|cells cells|compound|END_ENTITY	CD4 + T cells in cancer_stroma , not CD8 + T cells in cancer cell nests , are associated with favorable prognosis in human non-small_cell_lung_cancers .
14621007	0	CD8	24,27	CD4	20,23	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|END_ENTITY	Increased thymocyte CD4 + CD8 + cells and T-cell_receptor beta gene rearrangements in thymoma .
14635030	0	CD8	41,44	CD4	12,15	CD8	CD4	925	920	Gene	Gene	generation|compound|START_ENTITY required|nmod|generation required|nsubjpass|cells cells|compound|END_ENTITY	Mini-review CD4 T cells are required for CD8 T cell memory generation .
14707745	0	CD8	0,3	CD4	50,53	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	CD8 + tumor-infiltrating lymphocytes together with CD4 + tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic_adenocarcinoma .
14722622	0	CD8	77,80	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY mediated|nmod|cells rejection|acl|mediated suppress|dobj|rejection +|ccomp|suppress +|nsubj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress allograft rejection mediated by memory CD8 + T cells via a CD30-dependent mechanism .
14971034	0	CD8	53,56	CD4	0,3	CD8	CD4	925	920	Gene	Gene	memory|compound|START_ENTITY fitness|nmod|memory guarantee|iobj|fitness guarantee|nsubj|cells cells|compound|END_ENTITY	CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells .
14975355	0	CD8	153,156	CD4	147,150	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Expression of costimulatory molecules -LRB- CD80 , CD86 , CD28 , CD152 -RRB- , accessory molecules -LRB- TCR alphabeta , TCR gammadelta -RRB- and T cell lineage molecules -LRB- CD4 + , CD8 + -RRB- in PBMC of leprosy patients using Mycobacterium_leprae antigen -LRB- MLCWA -RRB- with murabutide and T cell peptide of Trat protein .
14999599	0	CD8	22,25	CD4	83,86	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY requires|nmod|T requires|dobj|help help|compound|END_ENTITY	In vitro human memory CD8 T cell expansion in response to cytomegalovirus requires CD4 + T cell help .
15031541	4	CD8	541,544	CD4	535,538	CD8	CD4	428800(Tax:9031)	395362(Tax:9031)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The percentage of CD3 -LRB- + -RRB- cells , CD4 -LRB- + -RRB- cells , CD8_alpha -LRB- + -RRB- cells , CD8_beta -LRB- + -RRB- , and CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- cells was 76 % , 41 % , 14 % , 5 % , and 15 % , respectively .
15033791	0	CD8	110,113	CD4	0,3	CD8	CD4	925	920	Gene	Gene	apoptosis|compound|START_ENTITY inhibition|nmod|apoptosis dependent|nmod|inhibition dependent|nsubj|increases increases|nummod|+ +|compound|END_ENTITY	CD4 + lymphocyte increases in HIV patients during potent antiretroviral therapy are dependent on inhibition of CD8 + cell apoptosis .
1505636	0	CD8	13,16	CD4	9,12	CD8	CD4	925	920	Gene	Gene	ratios|nummod|START_ENTITY END_ENTITY|dep|ratios	Abnormal CD4 : CD8 ratios and delayed germinal center reconstitution in lymph nodes of human graft recipients with graft-versus-host_disease -LRB- GVHD -RRB- : an immunohistological study .
15117448	0	CD8	0,3	CD4	60,63	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY predict|nsubj|cells predict|dobj|loss loss|compound|END_ENTITY	CD8 + CD38 + T cells but not HIV_type_1 RNA viral load predict CD4 + T cell loss in a predominantly minority female HIV + adolescent population .
15134772	0	CD8	33,36	CD4	65,68	CD8	CD4	925	920	Gene	Gene	memory|compound|START_ENTITY definition|nmod|memory Towards|nsubj|definition Towards|dep|help help|nsubj|role role|nmod|T-cell T-cell|compound|END_ENTITY	Towards a cellular definition of CD8 + T-cell memory : the role of CD4 + T-cell help in CD8 + T-cell responses .
15134772	0	CD8	85,88	CD4	65,68	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY help|nmod|responses help|nsubj|role role|nmod|T-cell T-cell|compound|END_ENTITY	Towards a cellular definition of CD8 + T-cell memory : the role of CD4 + T-cell help in CD8 + T-cell responses .
15147571	0	CD8	19,22	CD4	125,128	CD8	CD4	925	920	Gene	Gene	memory|compound|START_ENTITY Aberration|nmod|memory T|nsubj|Aberration T|parataxis|helper helper|dobj|bias bias|nmod|cells cells|compound|END_ENTITY	Aberration of CCR7 CD8 memory T cells from patients with systemic_lupus_erythematosus : an inducer of T helper type 2 bias of CD4 T cells .
1516633	0	CD8	111,114	CD4	107,110	CD8	CD4	925	920	Gene	Gene	clone|compound|START_ENTITY clone|compound|END_ENTITY	CD4-class II major histocompatibility complex interaction does not enhance killing by a class I-restricted CD4 + CD8 + cytotoxic T cell clone .
15173593	0	CD8	7,10	CD4	0,3	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	CD4 on CD8 -LRB- + -RRB- T cells directly enhances effector function and is a target for HIV_infection .
15308119	0	CD8	61,64	CD4	0,3	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY activity|nmod|+ inhibit|dobj|activity inhibit|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells inhibit cytotoxic activity of T CD8 + and NK lymphocytes in the direct cell-to-cell interaction .
15331721	0	CD8	57,60	CD4	84,87	CD8	CD4	925	920	Gene	Gene	infection|nmod|START_ENTITY levels|nmod|infection lymphocytes|nsubj|levels lymphocytes|xcomp|expressing expressing|dobj|END_ENTITY	High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo .
1533569	0	CD8	152,155	CD4	146,149	CD8	CD4	925	920	Gene	Gene	+|appos|START_ENTITY +|appos|END_ENTITY	Different sensitivity to interleukin_4 of interleukin_2 - and interferon alpha-induced CD69 antigen expression in human resting NK cells and CD3 + , CD4 - , CD8 - lymphocytes .
15340654	0	CD8	26,29	CD4	42,45	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|nmod|T T|compound|END_ENTITY	Giant_cell_arteritis with CD8 + instead of CD4 + T lymphocytes as the predominant infiltrating cells in a young woman .
1535793	0	CD8	17,20	CD4	12,15	CD8	CD4	925	920	Gene	Gene	double-negative|dep|START_ENTITY double-negative|compound|END_ENTITY	Presence of CD4 , CD8 double-negative and T-cell receptor-gamma-delta-positive T cells in lymphocyte cultures propagated from coronary arteries from heart transplant patients with graft coronary disease .
15366657	6	CD8	1031,1034	CD4	1070,1073	CD8	CD4	925	920	Gene	Gene	+|dep|START_ENTITY majority|nmod|+ T|nsubj|majority T|ccomp|HIV-1 HIV-1|dobj|PBMC PBMC|compound|END_ENTITY	The majority of p24 + / CD4 - / CD8 - T lymphocytes were HIV-1 infected CD4 down-modulated PBMC .
15380534	0	CD8	0,3	CD4	88,91	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY reach|nsubj|cells reach|nmod|numbers numbers|nmod|cells cells|nummod|END_ENTITY	CD8 + T cells responding to influenza_infection reach and persist at higher numbers than CD4 + T cells independently of precursor frequency .
1544171	0	CD8	56,59	CD4	52,55	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Thymic nurse cells exclusively bind and internalize CD4 + CD8 + thymocytes .
15475958	0	CD8	54,57	CD4	8,11	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY cells|nmod|T licensing|nmod|cells T|dep|licensing T|compound|END_ENTITY	Cognate CD4 -LRB- + -RRB- T cell licensing of dendritic cells in CD8 -LRB- + -RRB- T cell immunity .
15600300	0	CD8	102,105	CD4	91,94	CD8	CD4	925	920	Gene	Gene	expression|dep|START_ENTITY expression|dep|correlation correlation|nmod|CD25 CD25|compound|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
15725752	0	CD8	111,114	CD4	120,123	CD8	CD4	925	920	Gene	Gene	conservation|nmod|START_ENTITY vaccine|appos|conservation elicited|nmod|vaccine elicited|nmod|responses responses|compound|END_ENTITY	Studies in macaques on cross-clade T cell responses elicited by a DNA/MVA AIDS vaccine , better conservation of CD8 than CD4 T cell responses .
15731226	0	CD8	18,21	CD4	42,45	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY Modulation|nmod|+ Modulation|dep|response response|nmod|CD25 CD25|compound|END_ENTITY	Modulation of the CD8 + - T-cell response by CD4 + CD25 + regulatory T cells in patients with hepatitis_B_virus infection .
15731353	0	CD8	20,23	CD4	4,7	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY molecule|nmod|lymphocytes molecule|compound|END_ENTITY	The CD4 molecule on CD8 + T lymphocytes directly enhances the immune response to viral and cellular antigens .
1574118	0	CD8	101,104	CD4	30,33	CD8	CD4	925	920	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|interaction interaction|nmod|END_ENTITY	MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8 .
15744305	0	CD8	26,29	CD4	0,3	CD8	CD4	925	920	Gene	Gene	memory|compound|START_ENTITY help|dobj|memory help|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + T-cell help controls CD8 + T-cell memory via TRAIL-mediated activation-induced cell death .
15816016	0	CD8	38,41	CD4	81,84	CD8	CD4	925	920	Gene	Gene	cytotoxicity|compound|START_ENTITY important|nmod|cytotoxicity important|nmod|absence absence|nmod|help help|compound|END_ENTITY	IL-4Ralpha signaling is important for CD8 + T cell cytotoxicity in the absence of CD4 + T cell help .
1586742	0	CD8	77,80	CD4	72,75	CD8	CD4	925	920	Gene	Gene	START_ENTITY|nmod|proliferation proliferation|nmod|population population|nmod|END_ENTITY	Evidence for in vivo clonal proliferation of unique population of blood CD4 - / CD8 - T cells bearing T-cell receptor alpha and beta chains in two normal men .
15884050	0	CD8	6,9	CD4	49,52	CD8	CD4	925	920	Gene	Gene	blasts|compound|START_ENTITY sensitive|nsubj|blasts sensitive|nmod|blasts blasts|compound|END_ENTITY	Human CD8 + T cell blasts are more sensitive than CD4 + T cell blasts to regulation by APO2L/TRAIL .
15944248	0	CD8	23,26	CD4	58,61	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY model|nmod|T effector|nsubj|model effector|dobj|responses responses|nmod|cells cells|compound|END_ENTITY	A new dynamic model of CD8 + T effector cell responses via CD4 + T helper-antigen-presenting cells .
15968737	0	CD8	64,67	CD4	18,21	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY enhances|dobj|response enhances|nsubj|Depletion Depletion|nmod|cells cells|compound|END_ENTITY	Depletion of CD25 + CD4 + T cells -LRB- Tregs -RRB- enhances the HBV-specific CD8 + T cell response primed by DNA immunization .
15972637	0	CD8	93,96	CD4	139,142	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|independent independent|nmod|help help|compound|END_ENTITY	Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help .
16005184	0	CD8	43,46	CD4	10,13	CD8	CD4	925	920	Gene	Gene	function|compound|START_ENTITY +|nmod|function +|nsubj|Effect Effect|nmod|CD25 CD25|compound|END_ENTITY	Effect of CD4 + CD25 + regulatory T-cells on CD8 T-cell function in patients with autoimmune_hepatitis .
16006219	0	CD8	21,24	CD4	14,17	CD8	CD4	925	920	Gene	Gene	status|compound|START_ENTITY status|dep|Evaluation Evaluation|nmod|END_ENTITY	Evaluation of CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- status and urinary_tract_infections associated with urinary_schistosomiasis among some rural Nigerians .
16060130	0	CD8	69,72	CD4	64,67	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Effect of hormone replacement therapy on CD4 + and CD8 + numbers , CD4 + / CD8 + ratio , and immunoglobulin levels in hemodialysis patients .
16078259	0	CD8	24,27	CD4	29,32	CD8	CD4	925	920	Gene	Gene	CD68|compound|START_ENTITY CD68|appos|END_ENTITY	The predictive value of CD8 , CD4 , CD68 , and human leukocyte antigen-D-related cells in the prognosis of cutaneous_malignant_melanoma with vertical growth phase .
16210586	0	CD8	64,67	CD4	60,63	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Inefficient cell spreading and cytoskeletal polarization by CD4 + CD8 + thymocytes : regulation by the thymic environment .
16219490	0	CD8	85,88	CD4	95,98	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Transfection of dendritic cells with in vitro-transcribed CMV RNA induces polyclonal CD8 + - and CD4 + - mediated CMV-specific T cell responses .
16288380	0	CD8	153,156	CD4	0,3	CD8	CD4	925	920	Gene	Gene	activation|compound|START_ENTITY influenced|nmod|activation influenced|nsubjpass|recovery recovery|compound|END_ENTITY	CD4 + T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8 + T cell activation .
16398656	0	CD8	85,88	CD4	81,84	CD8	CD4	925	920	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	TLX1/HOX11-mediated disruption of primary thymocyte differentiation prior to the CD4 + CD8 + double-positive stage .
16438648	0	CD8	32,35	CD4	26,29	CD8	CD4	925	920	Gene	Gene	persistence|dep|START_ENTITY persistence|nmod|END_ENTITY	HIV_type_1 persistence in CD4 - / CD8 - double_negative T cells from patients on antiretroviral therapy .
16443370	0	CD8	47,50	CD4	14,17	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY Treg|nmod|+ Treg|compound|END_ENTITY	The impact of CD4 + CD25 + Treg on tumor specific CD8 + T cell cytotoxicity and cancer .
16448546	0	CD8	47,50	CD4	43,46	CD8	CD4	925	920	Gene	Gene	Role|dep|START_ENTITY Role|nmod|Th-POK Th-POK|nmod|END_ENTITY	Role of the transcription factor Th-POK in CD4 : CD8 lineage commitment .
16455988	0	CD8	20,23	CD4	94,97	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY generated|nsubjpass|cells generated|xcomp|alloantigen alloantigen|nmod|help help|compound|END_ENTITY	Effector and memory CD8 + T cells can be generated in response to alloantigen independently of CD4 + T cell help .
16456009	0	CD8	54,57	CD4	17,20	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY enhances|dobj|responses enhances|nsubj|ligation ligation|nmod|cells cells|compound|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16506292	0	CD8	31,34	CD4	27,30	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intestinal double-positive CD4 + CD8 + T cells are highly activated memory cells with an increased capacity to produce cytokines .
16529787	0	CD8	120,123	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells dependent|nmod|activity measles_virus|parataxis|dependent measles_virus|nsubj|primary primary|compound|END_ENTITY	CD4 T cell control primary measles_virus infection of the CNS : regulation is dependent on combined activity with either CD8 T cells or with B cells : CD4 , CD8 or B cells alone are ineffective .
16529787	0	CD8	120,123	CD4	149,152	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells dependent|nmod|activity measles_virus|parataxis|dependent measles_virus|parataxis|ineffective ineffective|nsubj|cells cells|compound|END_ENTITY	CD4 T cell control primary measles_virus infection of the CNS : regulation is dependent on combined activity with either CD8 T cells or with B cells : CD4 , CD8 or B cells alone are ineffective .
16551878	0	CD8	24,27	CD4	194,197	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY stimulation|nmod|cells vitro|dobj|stimulation epitope|advcl|vitro epitope|nsubj|T-cell T-cell|compound|END_ENTITY	In vitro stimulation of CD8 and CD4 T cells by dendritic cells loaded with a complex of cholesterol-bearing hydrophobized pullulan and NY-ESO-1 protein : Identification of a new HLA-DR15-binding CD4 T-cell epitope .
16585963	0	CD8	82,85	CD4	29,32	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY protecting|dobj|cells untransformed|advcl|protecting untransformed|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death .
16604076	0	CD8	41,44	CD4	96,99	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY generation|nmod|cells requires|nsubj|generation requires|dobj|cells cells|nummod|END_ENTITY	The generation of protective memory-like CD8 + T cells during homeostatic proliferation requires CD4 + T cells .
16612374	0	CD8	45,48	CD4	70,73	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|nmod|sites sites|nmod|interaction interaction|compound|END_ENTITY	Chemokines enhance immunity by guiding naive CD8 + T cells to sites of CD4 + T cell-dendritic cell interaction .
16673447	0	CD8	40,43	CD4	0,3	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY required|nmod|responses required|nsubjpass|help help|nummod|END_ENTITY	CD4 T cell help is required for primary CD8 T cell responses to vesicular antigen delivered to dendritic cells in vivo .
16699374	0	CD8	52,55	CD4	99,102	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ expansion|nmod|decrease decrease|nmod|cells cells|compound|END_ENTITY	IL-7 administration to humans leads to expansion of CD8 + and CD4 + cells but a relative decrease of CD4 + T-regulatory cells .
1672332	0	CD8	18,21	CD4	94,97	CD8	CD4	925	920	Gene	Gene	Subpopulations|nmod|START_ENTITY +|nsubj|Subpopulations +|ccomp|collaborate collaborate|nmod|absence absence|nmod|cells cells|compound|END_ENTITY	Subpopulations of CD8 + cytotoxic T cell precursors collaborate in the absence of conventional CD4 + helper T cells .
1673445	0	CD8	0,3	CD4	94,97	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY inhibit|nsubj|cells inhibit|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD8 + suppressor cells inhibit staphylococcal_protein_A-induced gamma interferon production by CD4 + lymphocytes .
16767155	0	CD8	65,68	CD4	60,63	CD8	CD4	925	920	Gene	Gene	thymic_lymphoma|compound|START_ENTITY thymic_lymphoma|compound|END_ENTITY	CD95 ligand mediates T-cell_receptor-induced apoptosis of a CD4 + CD8 + double positive thymic_lymphoma .
16769750	0	CD8	24,27	CD4	0,3	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY inhibit|dobj|response inhibit|nsubj|cells cells|compound|END_ENTITY	CD4 T cells inhibit the CD8 T cell response during low-dose virus_infection .
16799989	0	CD8	106,109	CD4	58,61	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY function|nmod|responses function|compound|END_ENTITY	Outcome of acute hepatitis_C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses .
1682152	0	CD8	4,7	CD4	0,3	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD8 + CD3high thymocytes appear transiently during ontogeny : evidence from phenotypic and functional studies .
16824651	0	CD8	15,18	CD4	39,42	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|cells cells|compound|END_ENTITY	Maintenance of CD8 effector T cells by CD4 helper T cells eradicates growing tumors and promotes long-term tumor immunity .
16828790	0	CD8	31,34	CD4	101,104	CD8	CD4	925	920	Gene	Gene	Generation|nmod|START_ENTITY +|nsubj|Generation +|nmod|cells cells|nummod|END_ENTITY	Generation of peptide-specific CD8 + T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4 + T cells .
1683650	0	CD8	70,73	CD4	65,68	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Immunostimulatory activity of lactotransferrin and maturation of CD4 - CD8 - murine thymocytes .
16839913	0	CD8	36,39	CD4	31,34	CD8	CD4	925	920	Gene	Gene	ration|compound|START_ENTITY ration|compound|END_ENTITY	Alterations in serum cortisol , CD4 + CD8 + lymphocyte sub-population ration and T cell mediated suppression of immune responses in the malnutrition of anorexia_nervosa .
16849444	0	CD8	72,75	CD4	22,25	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY recruitment|nmod|cells promotes|dobj|recruitment promotes|nsubj|help help|compound|END_ENTITY	Cutting edge : cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells .
1690353	0	CD8	61,64	CD4	57,60	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
1690353	0	CD8	61,64	CD4	91,94	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ regulation|nmod|expression thymocytes|nsubj|regulation thymocytes|dep|influenced influenced|nmod|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
16914556	0	CD8	71,74	CD4	67,70	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Modulation of pro- and antiapoptotic molecules in double-positive -LRB- CD4 + CD8 + -RRB- thymocytes following dexamethasone treatment .
16925953	0	CD8	57,60	CD4	51,54	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY _|dobj|+ _|nmod|differences differences|nmod|lymphocyte lymphocyte|appos|+ +|compound|END_ENTITY	Within and between race differences in lymphocyte , CD4 + , _ CD8 + and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda .
16977797	0	CD8	22,25	CD4	38,41	CD8	CD4	925	920	Gene	Gene	expression|nmod|START_ENTITY antigens|nsubj|expression antigens|nmod|cells cells|compound|END_ENTITY	A false expression of CD8 antigens on CD4 + T cells in a routine flow cytometry analysis .
16980510	0	CD8	32,35	CD4	0,3	CD8	CD4	925	920	Gene	Gene	T|nsubj|START_ENTITY stimulate|ccomp|T T|ccomp|stimulate T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cells stimulate memory CD8 -LRB- + -RRB- T cell expansion via acquired pMHC I complexes and costimulatory molecules , and IL-2 secretion .
17030653	0	CD8	13,16	CD4	8,11	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	Altered CD4 + / CD8 + T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple_sclerosis .
17047079	0	CD8	15,18	CD4	41,44	CD8	CD4	925	920	Gene	Gene	T-cell|compound|START_ENTITY Attenuation|nmod|T-cell function|nsubj|Attenuation function|nmod|CD25 CD25|compound|END_ENTITY	Attenuation of CD8 -LRB- + -RRB- T-cell function by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in B-cell_non-Hodgkin 's _ lymphoma .
17050078	0	CD8	22,25	CD4	18,21	CD8	CD4	925	920	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	A double-positive CD4 + CD8 + T-cell population is commonly found in nodular lymphocyte predominant Hodgkin_lymphoma .
1706390	1	CD8	155,158	CD4	84,87	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY Requirement|nmod|cells Requirement|nmod|interaction interaction|nmod|cells cells|compound|END_ENTITY	Requirement for interaction with infected CD4 + cells and induction of infectious virus from chronically infected CD8 + cells .
1707762	0	CD8	73,76	CD4	113,116	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|dep|stimulation stimulation|nmod|subset subset|compound|END_ENTITY	Differential responses of CD4 + CD45RA + and CD4 + CD29 + subsets to activated CD8 + cells : enhanced stimulation of the CD4 + CD45RA + subset by cells from patients with multiple_sclerosis .
1707762	0	CD8	73,76	CD4	26,29	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ activated|dobj|cells subsets|xcomp|activated subsets|nsubj|responses responses|nmod|+ +|compound|END_ENTITY	Differential responses of CD4 + CD45RA + and CD4 + CD29 + subsets to activated CD8 + cells : enhanced stimulation of the CD4 + CD45RA + subset by cells from patients with multiple_sclerosis .
17082578	0	CD8	13,16	CD4	9,12	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Immature CD4 + CD8 + thymocytes and mature T cells regulate Nur77 distinctly in response to TCR stimulation .
17085920	0	CD8	13,16	CD4	28,31	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|appos|T T|appos|+ +|compound|END_ENTITY	Decreases in CD8 + T , naive -LRB- CD4 + CD45RA + -RRB- T , and B -LRB- CD19 + -RRB- lymphocytes by exposure to manganese fume .
17090688	0	CD8	106,109	CD4	102,105	CD8	CD4	925	920	Gene	Gene	line|compound|START_ENTITY line|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
17090688	0	CD8	106,109	CD4	61,64	CD8	CD4	925	920	Gene	Gene	line|compound|START_ENTITY differentiation|nmod|line differentiation|compound|END_ENTITY	Rac1-mediated Bcl-2 induction is critical in antigen-induced CD4 single-positive differentiation of a CD4 + CD8 + immature thymocyte line .
17123986	0	CD8	25,28	CD4	0,3	CD8	CD4	925	920	Gene	Gene	T-cell|compound|START_ENTITY count|nsubj|T-cell counts|dep|count counts|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + T-cell counts , CD4 + / CD8 + T-cell count ratios , and antibody levels in migrant fishermen infected with Schistosoma_japonicum in the Dongting Lake , China .
17123986	0	CD8	25,28	CD4	20,23	CD8	CD4	925	920	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	CD4 + T-cell counts , CD4 + / CD8 + T-cell count ratios , and antibody levels in migrant fishermen infected with Schistosoma_japonicum in the Dongting Lake , China .
17163450	0	CD8	0,3	CD4	45,48	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|dobj|regulation regulation|nmod|responses responses|compound|END_ENTITY	CD8 + suppressor-mediated regulation of human CD4 + T cell responses to glutamic_acid decarboxylase 65 .
1719558	0	CD8	51,54	CD4	47,50	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ligand-stimulated signaling events in immature CD4 + CD8 + thymocytes expressing competent T-cell receptor complexes .
1721862	0	CD8	11,14	CD4	6,9	CD8	CD4	925	920	Gene	Gene	CD7|dep|START_ENTITY CD7|nummod|END_ENTITY	CD7 + , CD4 - / CD8 - acute_leukemia with t -LRB- 11 ; 14 -RRB- -LRB- p15 ; q11 -RRB- in a child .
17249210	0	CD8	61,64	CD4	54,57	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Study of the significance of percentage of peripheral CD4 + _ CD8 + T cells and the hepatitis_C virus genotypes in Egyptian patients with chronic hepatitis_C .
17258077	0	CD8	45,48	CD4	39,42	CD8	CD4	925	920	Gene	Gene	IL-2-independent|dep|START_ENTITY IL-2-independent|dobj|generation generation|nmod|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17277112	0	CD8	83,86	CD4	21,24	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY priming|nmod|cells facilitate|xcomp|priming facilitate|nsubj|cells cells|compound|END_ENTITY	Type I IFN-producing CD4 Valpha14i NKT cells facilitate priming of IL-10-producing CD8 T cells by hepatocytes .
17277113	0	CD8	111,114	CD4	8,11	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY impair|nmod|cells help|ccomp|impair help|nsubj|+ +|compound|END_ENTITY	Cognate CD4 + help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8 + T cells .
17313653	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD8 + T cells in young and elderly humans .
17339421	0	CD8	47,50	CD4	78,81	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY ligand|dobj|cells ligand|nmod|absence absence|nmod|help help|compound|END_ENTITY	TLR3 ligand stimulates fully functional memory CD8 + T cells in the absence of CD4 + T-cell help .
17375073	0	CD8	35,38	CD4	15,18	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY cells|nmod|response elicited|nsubj|cells elicited|nmod|role role|nmod|T T|compound|END_ENTITY	On the role of CD4 + T cells in the CD8 + T-cell response elicited by recombinant adenovirus vaccines .
17438031	0	CD8	35,38	CD4	7,10	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY enhance|dobj|responses enhance|nsubj|cells cells|compound|END_ENTITY	Memory CD4 T cells enhance primary CD8 T-cell responses .
17442927	0	CD8	87,90	CD4	6,9	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY memory|dep|response elicit|dobj|memory displaying|ccomp|elicit +|dep|displaying +|nsubj|END_ENTITY	Human CD4 + T cells displaying viral epitopes elicit a functional virus-specific memory CD8 + T cell response .
17475864	0	CD8	57,60	CD4	16,19	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY dependent|nsubj|responses help|ccomp|dependent help|nsubj|Requirement Requirement|nmod|cell cell|compound|END_ENTITY	Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent .
1750726	0	CD8	41,44	CD4	36,39	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY induction|dep|cells induction|nmod|+ +|compound|END_ENTITY	Interleukin_4-mediated induction of CD4 + / CD8 + T cells during infancy .
17513729	0	CD8	111,114	CD4	24,27	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY targeted|nmod|responses those|acl|targeted distinct|nmod|those target|xcomp|distinct target|nsubj|responses responses|compound|END_ENTITY	Vaccinia_virus-specific CD4 + T cell responses target a set of antigens largely distinct from those targeted by CD8 + T cell responses .
17898053	0	CD8	13,16	CD4	133,136	CD8	CD4	925	920	Gene	Gene	T-cell|compound|START_ENTITY macaques|nsubj|T-cell macaques|nmod|activation activation|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
17917058	0	CD8	0,3	CD4	31,34	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|dep|T T|compound|END_ENTITY	CD8 T cell memory development : CD4 T cell help is appreciated .
17947656	0	CD8	137,140	CD4	15,18	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells influence|dobj|expansion priming|ccomp|influence cell|acl|priming generated|nmod|cell generated|nsubj|cells cells|nummod|END_ENTITY	Cognate memory CD4 + T cells generated with dendritic cell priming influence the expansion , trafficking , and differentiation of secondary CD8 + T cells and enhance tumor control .
17967458	0	CD8	83,86	CD4	53,56	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY impairs|dobj|response impairs|nsubj|response response|nmod|cells cells|compound|END_ENTITY	Defective T helper response of hepatocyte-stimulated CD4 T cells impairs antiviral CD8 response and viral clearance .
17981791	0	CD8	43,46	CD4	39,42	CD8	CD4	925	920	Gene	Gene	differentiation|compound|START_ENTITY differentiation|compound|END_ENTITY	Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex , by mimicking pre-TCR signals .
17997138	0	CD8	82,85	CD4	57,60	CD8	CD4	925	920	Gene	Gene	activation|compound|START_ENTITY counts|dobj|activation counts|nsubj|END_ENTITY	Intensification of a suppressive HAART regimen increases CD4 counts and decreases CD8 + T-cell activation .
18021092	0	CD8	45,48	CD4	41,44	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Age-dependent accumulation of monoclonal CD4 + CD8 + double positive T lymphocytes in the peripheral blood of the elderly .
18056368	0	CD8	29,32	CD4	0,3	CD8	CD4	925	920	Gene	Gene	survival|compound|START_ENTITY required|nmod|survival required|nsubjpass|cells cells|compound|END_ENTITY	CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses .
18090392	0	CD8	15,18	CD4	19,22	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|dobj|decay decay|compound|END_ENTITY	HIV-1-infected CD8 + CD4 + T cells decay in vivo at a similar rate to infected CD4 T cells during HAART .
18090392	0	CD8	15,18	CD4	76,79	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|rate rate|nmod|cells cells|compound|END_ENTITY	HIV-1-infected CD8 + CD4 + T cells decay in vivo at a similar rate to infected CD4 T cells during HAART .
18184713	0	CD8	25,28	CD4	13,16	CD8	CD4	925	920	Gene	Gene	responses|nummod|START_ENTITY +|nmod|responses +|compound|END_ENTITY	Differential CD4 + versus CD8 + T-cell responses elicited by different poxvirus-based human_immunodeficiency_virus_type_1 vaccine candidates provide comparable efficacies in primates .
18246596	0	CD8	87,90	CD4	29,32	CD8	CD4	925	920	Gene	Gene	elimination|compound|START_ENTITY growth|nmod|elimination CCL5|nmod|growth CCL5|compound|END_ENTITY	Gastric_cancer cells exploit CD4 + cell-derived CCL5 for their growth and prevention of CD8 + cell-involved tumor elimination .
1825509	0	CD8	18,21	CD4	13,16	CD8	CD4	925	920	Gene	Gene	T-cell_leukemia|compound|START_ENTITY patient|dep|T-cell_leukemia patient|nmod|END_ENTITY	A patient of CD4 - / CD8 + chronic T-cell_leukemia associated with hypercalcemia .
18257774	0	CD8	19,22	CD4	59,62	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells has|nsubj|expression has|dobj|association association|nmod|recovery recovery|compound|END_ENTITY	CD38 expression on CD8 T cells has a weak association with CD4 T-cell recovery and is a poor marker of viral replication in HIV-1-infected patients on antiretroviral therapy .
1825806	0	CD8	6,9	CD4	52,55	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY lymphocytes|nsubj|+ lymphocytes|dep|stimulated stimulated|nmod|absence absence|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Human CD8 + lymphocytes stimulated in the absence of CD4 + cells enhance IgG production by antibody-secreting B cells .
1827129	0	CD8	24,27	CD4	19,22	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY analysis|dep|cells analysis|nmod|+ +|compound|END_ENTITY	Clonal analysis of CD4 + / CD8 + T cells in a patient with aplastic_anemia .
18273057	0	CD8	78,81	CD4	40,43	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY enhancing|dobj|responses secreted|advcl|enhancing secreted|nmod|cells cells|compound|END_ENTITY	Role of IL-2 secreted by PADRE-specific CD4 + T cells in enhancing E7-specific CD8 + T-cell immune responses .
1828937	0	CD8	5,8	CD4	40,43	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells cells|nmod|skin_lesions skin_lesions|nmod|mycosis_fungoides mycosis_fungoides|compound|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18292535	0	CD8	100,103	CD4	15,18	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY render|nmod|cells render|nsubj|cells cells|compound|END_ENTITY	Tumor-specific CD4 + T cells render the tumor environment permissive for infiltration by low-avidity CD8 + T cells .
1829396	0	CD8	67,70	CD4	62,65	CD8	CD4	925	920	Gene	Gene	Regulation|dep|START_ENTITY Regulation|nmod|proliferation proliferation|nmod|END_ENTITY	Regulation of thymocyte proliferation by alpha beta TcR + CD3 + CD4 - CD8 - cloned natural suppressor -LRB- NS -RRB- cells .
18362335	0	CD8	37,40	CD4	23,26	CD8	CD4	925	920	Gene	Gene	longevity|compound|START_ENTITY help|nmod|longevity help|nsubj|IL-15 IL-15|nmod|mediator mediator|nmod|+ +|compound|END_ENTITY	IL-15 as a mediator of CD4 + help for CD8 + T cell longevity and avoidance of TRAIL-mediated apoptosis .
18367534	0	CD8	48,51	CD4	32,35	CD8	CD4	925	920	Gene	Gene	rhesus_monkeys|nummod|START_ENTITY cells|nmod|rhesus_monkeys cells|nummod|END_ENTITY	Increased loss of CCR5 + CD45RA - CD4 + T cells in CD8 + lymphocyte-depleted Simian_immunodeficiency_virus-infected rhesus_monkeys .
1846951	0	CD8	64,67	CD4	13,16	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY HIV-1_infection|nmod|T END_ENTITY|nmod|HIV-1_infection	Induction of CD4 and susceptibility to HIV-1_infection in human CD8 + T lymphocytes by human_herpesvirus_6 .
18490719	0	CD8	82,85	CD4	49,52	CD8	CD4	925	920	Gene	Gene	rejection|compound|START_ENTITY required|nmod|rejection required|nsubjpass|frequency frequency|nmod|help help|compound|END_ENTITY	A critical precursor frequency of donor-reactive CD4 + T cell help is required for CD8 + T cell-mediated CD28/CD154-independent rejection .
18504453	0	CD8	31,34	CD4	27,30	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	The FOXP3 + subset of human CD4 + CD8 + thymocytes is immature and subject to intrathymic selection .
18506879	0	CD8	26,29	CD4	0,3	CD8	CD4	925	920	Gene	Gene	memory|compound|START_ENTITY improves|dobj|memory improves|nsubj|help help|compound|END_ENTITY	CD4 + T cell help improves CD8 + T cell memory by retained CD27 expression .
18506880	0	CD8	22,25	CD4	66,69	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY response|nmod|deficiency deficiency|compound|END_ENTITY	Generating functional CD8 + T cell memory response under transient CD4 + T cell deficiency : implications for vaccination of immunocompromised individuals .
18515560	0	CD8	109,112	CD4	104,107	CD8	CD4	925	920	Gene	Gene	leukaemia|compound|START_ENTITY leukaemia|compound|END_ENTITY	Severe and recurrent episodes of bronchiolitis_obliterans_organising_pneumonia associated with indolent CD4 + CD8 + T-cell leukaemia .
18534691	0	CD8	107,110	CD4	102,105	CD8	CD4	925	920	Gene	Gene	expression|nummod|START_ENTITY END_ENTITY|appos|expression	Human umbilical cord blood-derived non-hematopoietic stem cells suppress lymphocyte proliferation and CD4 , CD8 expression .
18566395	0	CD8	59,62	CD4	0,3	CD8	CD4	925	920	Gene	Gene	memory|compound|START_ENTITY involved|nmod|memory genes|acl|involved expression|nmod|genes regulates|dobj|expression regulates|nsubj|help help|compound|END_ENTITY	CD4 help regulates expression of crucial genes involved in CD8 T cell memory and sensitivity to regulatory elements .
18602973	0	CD8	156,159	CD4	152,155	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
18602973	0	CD8	156,159	CD4	166,169	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY commitment|nmod|+ controlling|dobj|commitment controlling|nmod|thymocytes thymocytes|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
18606659	0	CD8	59,62	CD4	15,18	CD8	CD4	925	920	Gene	Gene	response|nummod|START_ENTITY provide|nmod|response instructs|xcomp|provide instructs|dobj|cells cells|compound|END_ENTITY	CD27 instructs CD4 + T cells to provide help for the memory CD8 + T cell response after protein immunization .
18649854	0	CD8	143,146	CD4	137,140	CD8	CD4	925	920	Gene	Gene	factors|appos|START_ENTITY factors|nmod|appearance appearance|nmod|END_ENTITY	Decreased maturation of T-cell populations in the healthy elderly : Influence of nutritional factors on the appearance of double negative CD4 - , CD8 - , CD2 + cells .
18676551	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY +|dep|ratio +|compound|END_ENTITY	CD4 + / CD8 + T cell ratio for diagnosis of HIV-1_infection in infants : Women and Infants Transmission Study .
18768393	0	CD8	54,57	CD4	44,47	CD8	CD4	925	920	Gene	Gene	+|dep|START_ENTITY NKa|dep|+ +|dep|NKa +|compound|END_ENTITY	Expanded cells in monoclonal TCR-alphabeta + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis recognize hCMV antigens .
18784457	0	CD8	5,8	CD4	44,47	CD8	CD4	925	920	Gene	Gene	T-cells|compound|START_ENTITY correlate|nsubj|T-cells correlate|nmod|cells cells|nummod|END_ENTITY	CD38 + CD8 + T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals .
18818318	0	CD8	63,66	CD4	118,121	CD8	CD4	925	920	Gene	Gene	murine_gammaherpesvirus_68|nmod|START_ENTITY cells|amod|murine_gammaherpesvirus_68 clearance|nmod|cells compromised|nsubjpass|clearance compromised|nmod|cells cells|compound|END_ENTITY	Primary clearance of murine_gammaherpesvirus_68 by PKCtheta - / - CD8 T cells is compromised in the absence of help from CD4 T cells .
18836718	0	CD8	62,65	CD4	57,60	CD8	CD4	925	920	Gene	Gene	Characterization|dep|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of MHC class-I restricted TCRalphabeta + CD4 - CD8 - double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination .
18941186	0	CD8	34,37	CD4	15,18	CD8	CD4	925	920	Gene	Gene	killers|compound|START_ENTITY rescue|dobj|killers help|xcomp|rescue help|nsubj|END_ENTITY	Heterospecific CD4 help to rescue CD8 T cell killers .
19047170	0	CD8	72,75	CD4	107,110	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells occur|nsubj|expansion occur|nmod|cells cells|compound|END_ENTITY	In vivo expansion , persistence , and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells .
19072838	0	CD8	21,24	CD4	91,94	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY association|nmod|+ association|dep|CD38 CD38|nmod|count count|compound|END_ENTITY	Close association of CD8 + / CD38 bright with HIV-1 replication and complex relationship with CD4 + T-cell count .
1911543	0	CD8	24,27	CD4	48,51	CD8	CD4	925	920	Gene	Gene	analysis|nmod|START_ENTITY expressed|nsubj|analysis expressed|nmod|T T|compound|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
1911543	0	CD8	53,56	CD4	48,51	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
19120311	0	CD8	21,24	CD4	47,50	CD8	CD4	925	920	Gene	Gene	role|nmod|START_ENTITY T|nsubj|role T|advcl|regulating regulating|dobj|responses responses|compound|END_ENTITY	The sentinel role of CD8 T cells in regulating CD4 T cell responses to proinsulin in beta-islet cell autoimmunity .
19133978	0	CD8	74,77	CD4	0,3	CD8	CD4	925	920	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dep|FoxP3 FoxP3|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19133978	0	CD8	74,77	CD4	68,71	CD8	CD4	925	920	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dobj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19139082	0	CD8	68,71	CD4	8,11	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY reactivation|nmod|cells essential|nmod|reactivation essential|nsubj|help help|compound|END_ENTITY	Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen , H60 .
19155494	0	CD8	72,75	CD4	18,21	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY autologous|dobj|+ autologous|nsubj|Human Human|acl|circulating circulating|dobj|+ +|compound|END_ENTITY	Human circulating CD4 + CD25highFoxp3 + regulatory T cells kill autologous CD8 + but not CD4 + responder cells by Fas-mediated apoptosis .
19176318	0	CD8	39,42	CD4	34,37	CD8	CD4	925	920	Gene	Gene	TCR_alpha|dep|START_ENTITY TCR_alpha|compound|END_ENTITY	FAS-L , IL-10 , and double-negative CD4 - CD8 - TCR_alpha / beta + T cells are reliable markers of autoimmune_lymphoproliferative_syndrome -LRB- ALPS -RRB- associated with FAS loss of function .
1920621	0	CD8	89,92	CD4	75,78	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|nmod|cells cells|compound|END_ENTITY	Inhibition of human immunodeficiency virus replication in acutely infected CD4 + cells by CD8 + cells involves a noncytotoxic mechanism .
19279095	0	CD8	45,48	CD4	0,3	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY priming|nmod|cells required|nmod|priming required|nsubjpass|cells cells|compound|END_ENTITY	CD4 + T cells are required for the priming of CD8 + T cells following infection with herpes_simplex_virus_type_1 .
19328310	0	CD8	67,70	CD4	62,65	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	-LSB- Two cases of subcutaneous panniculitis-like T-cell_lymphoma -LRB- CD4 - CD8 + CD56 - -RRB- -RSB- .
19410556	0	CD8	32,35	CD4	12,15	CD8	CD4	925	920	Gene	Gene	activation|compound|START_ENTITY help|nmod|activation help|nsubj|role role|nmod|cell cell|compound|END_ENTITY	The role of CD4 T cell help for CD8 CTL activation .
19429259	0	CD8	81,84	CD4	77,80	CD8	CD4	925	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Induction of S100A4 , S100A6 , and galectin-1 during the lineage commitment of CD4 + CD8 + thymocyte cell line is suppressed by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
19458000	0	CD8	45,48	CD4	150,153	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY determinants|nsubj|responses determinants|nmod|point point|nmod|cells cells|compound|END_ENTITY	Human_immunodeficiency_virus_type_1-specific CD8 + T-cell responses during primary_infection are major determinants of the viral set point and loss of CD4 + T cells .
19535638	0	CD8	90,93	CD4	49,52	CD8	CD4	925	920	Gene	Gene	responses|nummod|START_ENTITY generation|nmod|responses suppress|dobj|generation cells|ccomp|suppress cells|compound|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19546246	0	CD8	51,54	CD4	9,12	CD8	CD4	925	920	Gene	Gene	depletion|compound|START_ENTITY induced|nmod|depletion +|parataxis|induced +|compound|END_ENTITY	Profound CD4 + / CCR5 + T cell expansion is induced by CD8 + lymphocyte depletion but does not account for accelerated SIV pathogenesis .
19616200	0	CD8	15,18	CD4	11,14	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19620303	0	CD8	49,52	CD4	45,48	CD8	CD4	925	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Rare development of Foxp3 + thymocytes in the CD4 + CD8 + subset .
19692644	0	CD8	52,55	CD4	0,3	CD8	CD4	925	920	Gene	Gene	inflation|compound|START_ENTITY impact|nmod|inflation has|dobj|impact has|nsubj|help help|compound|END_ENTITY	CD4 + T cell help has an epitope-dependent impact on CD8 + T cell memory inflation during murine_cytomegalovirus_infection .
19700667	0	CD8	65,68	CD4	95,98	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|coexpresses coexpresses|dobj|END_ENTITY	Potent HIV-specific responses are enriched in a unique subset of CD8 + T cells that coexpresses CD4 on its surface .
1970668	0	CD8	21,24	CD4	0,3	CD8	CD4	925	920	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	CD4 + , CD8 + , and CD4 - CD8 - T cells in CSF and blood of patients with multiple_sclerosis and tension_headache .
1970729	0	CD8	27,30	CD4	22,25	CD8	CD4	925	920	Gene	Gene	CD4|dep|START_ENTITY +|dep|CD4 +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD8	35,38	CD4	22,25	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY CD8|nmod|+ CD4|dep|CD8 +|dep|CD4 +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD8	35,38	CD4	40,43	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY CD8|nmod|+ END_ENTITY|dep|CD8	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1972661	0	CD8	0,3	CD4	55,58	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY lymphocytes|nsubj|+ lymphocytes|xcomp|suppress suppress|nmod|cells cells|compound|END_ENTITY	CD8 + lymphocytes suppress HIV production by autologous CD4 + cells without eliminating the infected cells from culture .
19734235	0	CD8	56,59	CD4	22,25	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY derive|nmod|cells END_ENTITY|parataxis|derive	Human TCR-alpha beta + CD4 - CD8 - T cells can derive from CD8 + T cells and display an inflammatory effector phenotype .
1976704	0	CD8	54,57	CD4	50,53	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|differentiation differentiation|nmod|END_ENTITY	In vitro differentiation from a pluripotent human CD4 + CD8 + thymic cloned cell into four phenotypically distinct subsets .
1977770	0	CD8	34,37	CD4	29,32	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ +|parataxis|T +|compound|END_ENTITY	Elevated cerebrospinal fluid CD4 + / CD8 + T cell ratio in myasthenia_gravis .
19786539	0	CD8	0,3	CD4	59,62	CD8	CD4	925	920	Gene	Gene	depletion|compound|START_ENTITY induces|nsubj|depletion induces|dobj|proliferation proliferation|compound|END_ENTITY	CD8 + cell depletion of SHIV89.6P-infected macaques induces CD4 + T cell proliferation that contributes to increased viral loads .
1981372	0	CD8	130,133	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY suppress|nsubj|cells secrete|parataxis|suppress secrete|nsubj|cells cells|nummod|END_ENTITY	CD4 cells from patients with autoimmune_thyroid_disease secrete interferon_gamma after stimulation by thyroid_microsomal_antigen ; CD8 cells suppress this secretion .
19887050	0	CD8	18,21	CD4	45,48	CD8	CD4	925	920	Gene	Gene	NKT|nsubj|START_ENTITY NKT|dobj|cells cells|nmod|NKT NKT|compound|END_ENTITY	EBV-induced human CD8 -LRB- + -RRB- NKT cells synergise CD4 -LRB- + -RRB- NKT cells suppressing EBV-associated tumours upon induction of Th1-bias .
19898495	0	CD8	0,3	CD4	67,70	CD8	CD4	925	920	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|requires requires|dobj|T-cell T-cell|compound|END_ENTITY	CD8 -LRB- + -RRB- T lymphocyte mobilization to virus-infected tissue requires CD4 -LRB- + -RRB- T-cell help .
19901991	0	CD8	71,74	CD4	0,3	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY advances|dep|responses signals|nmod|advances signals|nsubj|IL-2 IL-2|compound|END_ENTITY	CD4 + T cell-derived IL-2 signals during early priming advances primary CD8 + T cell responses .
19917777	0	CD8	93,96	CD4	47,50	CD8	CD4	925	920	Gene	Gene	differentiation|compound|START_ENTITY important|nmod|differentiation important|nmod|repression repression|nummod|END_ENTITY	The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus .
19922421	0	CD8	114,117	CD4	63,66	CD8	CD4	925	920	Gene	Gene	memory|amod|START_ENTITY impairing|dobj|memory T|advcl|impairing T|nsubj|cells cells|acl|activated activated|ccomp|induce induce|dobj|END_ENTITY	Dendritic cells activated by an anti-inflammatory agent induce CD4 -LRB- + -RRB- T helper type 2 responses without impairing CD8 -LRB- + -RRB- memory and effector cytotoxic T-lymphocyte responses .
19949087	0	CD8	42,45	CD4	6,9	CD8	CD4	925	920	Gene	Gene	T|nsubj|START_ENTITY prevents|ccomp|T T|ccomp|prevents T|nsubj|END_ENTITY	Early CD4 -LRB- + -RRB- T cell help prevents partial CD8 -LRB- + -RRB- T cell exhaustion and promotes maintenance of Herpes_Simplex_Virus_1 latency .
19966302	0	CD8	87,90	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells controls|dobj|development controls|nsubj|regulation regulation|compound|END_ENTITY	CD4 + T cell regulation of CD25 expression controls development of short-lived effector CD8 + T cells in primary and secondary responses .
20045101	0	CD8	32,35	CD4	28,31	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY associated|nsubjpass|ratio loci|parataxis|associated loci|nmod|END_ENTITY	Quantitative trait loci for CD4 : CD8 lymphocyte ratio are associated with risk of type_1_diabetes_and_HIV-1 immune control .
20108768	0	CD8	34,37	CD4	28,31	CD8	CD4	925	920	Gene	Gene	START_ENTITY|nsubj|Frequency Frequency|appos|distribution distribution|nmod|+ +|compound|END_ENTITY	-LSB- Frequency , distribution of CD4 + , CD8 + T cells and expression of CD38 in gastric mucosa of HIV_infections -RSB- .
20142839	0	CD8	61,64	CD4	56,59	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	Foxp3 induction in human and murine thymus precedes the CD4 + CD8 + stage but requires early T-cell receptor expression .
20147961	0	CD8	34,37	CD4	17,20	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY assist|dobj|cells assist|nsubj|cells cells|compound|END_ENTITY	Antigen-specific CD4 cells assist CD8 T-effector cells in eliminating keratinocytes .
20156102	0	CD8	41,44	CD4	0,3	CD8	CD4	925	920	Gene	Gene	production|compound|START_ENTITY utilizing|nsubj|production inhibit|dep|utilizing T|ccomp|inhibit T|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells inhibit CD8 -LRB- + -RRB- IFN-gamma production during acute and chronic FIV_infection utilizing a membrane TGF-beta-dependent mechanism .
20157599	0	CD8	46,49	CD4	35,38	CD8	CD4	925	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Expression and Function of TLR2 on CD4 Versus CD8 T Cells .
20362206	0	CD8	113,116	CD4	53,56	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells help|nmod|development help|nsubj|epitopes epitopes|compound|END_ENTITY	Hepatitis_B_virus _ -LRB- HBV -RRB- - derived DRB1 * 0101-restricted CD4 T-cell epitopes help in the development of HBV-specific CD8 + T cells in vivo .
20368790	0	CD8	21,24	CD4	6,9	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY capture|nmod|cells capture|compound|END_ENTITY	Could CD4 capture by CD8 + T cells play a role in HIV spreading ?
20615979	0	CD8	85,88	CD4	80,83	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4 + CD8 + thymocytes .
20631314	0	CD8	57,60	CD4	32,35	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Beta-catenin signaling mediates CD4 expression on mature CD8 + T cells .
20639494	0	CD8	80,83	CD4	7,10	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY modulating|dobj|response limit|advcl|modulating limit|nsubj|cells cells|nummod|END_ENTITY	Foxp3 + CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory_syncytial_virus_infection .
20665390	2	CD8	384,387	CD4	380,383	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY values|dep|ratio values|nmod|END_ENTITY	Several independent groups found almost identical predictive values of the CD4 : CD8 ratio in BAL for the diagnosis of sarcoidosis .
20686045	0	CD8	86,89	CD4	28,31	CD8	CD4	925	920	Gene	Gene	function|compound|START_ENTITY preserving|dobj|function reduce|advcl|preserving reduce|nsubj|cells cells|compound|END_ENTITY	Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection .
20734711	0	CD8	14,17	CD4	9,12	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY associated|nsubj|ratio +|parataxis|associated +|compound|END_ENTITY	Inverted CD4 + / CD8 + ratio associated with AIDS event and death_in_HIV-1_infected individuals in Nasarawa State , Nigeria .
20739776	0	CD8	14,17	CD4	0,3	CD8	CD4	925	920	Gene	Gene	T-cell_large_granular_lymphocytic_leukemia|compound|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|nummod|+ +|compound|END_ENTITY	CD4 + / NKa _ + / CD8 -LRB- dim + -RRB- T-cell_large_granular_lymphocytic_leukemia : a rare entity .
20940398	0	CD8	91,94	CD4	0,3	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY function|nmod|lymphocytes required|nmod|function help|advcl|required help|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8 + T lymphocytes .
21033101	0	CD8	34,37	CD4	28,31	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY Expression|appos|+ Expression|appos|+ +|compound|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
21047960	0	CD8	128,131	CD4	31,34	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	function|compound|START_ENTITY modulation|nmod|function contribute|nmod|modulation contribute|nsubj|responses responses|compound|END_ENTITY	HIV-1-specific interleukin-21 + CD4 + T cell responses contribute to durable viral control through the modulation of HIV-specific CD8 + T cell function .
2105169	0	CD8	26,29	CD4	22,25	CD4	CD4	920	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Frequency analysis of CD4 + CD8 + T cells cloned with IL-4 .
21092106	0	CD8	79,82	CD4	0,3	CD8	CD4	925	920	Gene	Gene	targets|compound|START_ENTITY induce|nmod|targets T|ccomp|induce T|nsubj|+ +|compound|END_ENTITY	CD4 + CD25 + T regulatory cells from FIV + cats induce a unique anergic profile in CD8 + lymphocyte targets .
21098236	0	CD8	0,3	CD4	84,87	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	CD122|compound|START_ENTITY +|nsubj|CD122 +|ccomp|prevent prevent|dobj|colitis colitis|nummod|END_ENTITY	CD8 + CD122 + regulatory T cells -LRB- Tregs -RRB- and CD4 + Tregs cooperatively prevent and cure CD4 + cell-induced colitis .
21108468	0	CD8	45,48	CD4	0,3	CD8	CD4	925	920	Gene	Gene	subsets|compound|START_ENTITY contribution|nmod|subsets regulate|dobj|contribution regulate|nsubj|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Treg regulate the contribution of CD8 + T-cell subsets in repopulation of the lymphopenic environment .
21151195	0	CD8	26,29	CD4	34,37	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|nmod|memory memory|compound|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21151195	0	CD8	26,29	CD4	72,75	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY co-stimulation|nmod|+ cells|amod|co-stimulation supports|nsubj|cells supports|dobj|expansion expansion|nummod|END_ENTITY	CD40L co-stimulation from CD8 + to CD4 + effector memory T cells supports CD4 + expansion .
21165245	0	CD8	79,82	CD4	52,55	CD8	CD4	925	920	Gene	Gene	T-cells|compound|START_ENTITY 2|nmod|T-cells 2|dobj|Balance Balance|nmod|T-cells T-cells|compound|END_ENTITY	Association of Intracellular T -LRB- H -RRB- 1-T -LRB- H -RRB- 2 Balance in CD4 + T-cells and MIP-1a in CD8 + T-cells with Disease Severity in Adults with Dengue .
2120773	0	CD8	70,73	CD4	84,87	CD8	CD4	925	920	Gene	Gene	expression|nmod|START_ENTITY Inhibition|nmod|expression +|nsubj|Inhibition +|nmod|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
2125178	0	CD8	22,25	CD4	28,31	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|dep|- -|compound|END_ENTITY	Cytotoxic/suppressor -LRB- CD8 + , CD4 - -RRB- cutaneous_T-cell_lymphoma with aggressive course .
21263406	0	CD8	12,15	CD4	6,9	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|dobj|+ +|nsubj|END_ENTITY	Local CD4 + , CD8 + and CD56 + reactions to lung_cancer in regard to pathohistological type and clinical stage .
21264321	0	CD8	51,54	CD4	71,74	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY induce|dobj|cells induce|nmod|cells cells|compound|END_ENTITY	Liposome-coupled peptides induce long-lived memory CD8 T cells without CD4 T cells .
21287552	0	CD8	72,75	CD4	67,70	CD8	CD4	925	920	Gene	Gene	Characterization|dep|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the immunoregulatory function of human TCR-ab + CD4 - CD8 - double-negative T cells .
21312192	0	CD8	0,3	CD4	79,82	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ share|nsubj|cells share|nmod|cells cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
2140062	0	CD8	68,71	CD4	55,58	CD8	CD4	925	920	Gene	Gene	T4|appos|START_ENTITY T4|appos|END_ENTITY	Expansion of a lymphocyte population co-expressing T4 -LRB- CD4 -RRB- and T8 -LRB- CD8 -RRB- antigens in the peripheral blood of a normal adult male .
2141037	0	CD8	22,25	CD4	17,20	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Double-negative -LRB- CD4 - CD8 - -RRB- T cells with an alpha/beta T cell receptor .
2145216	0	CD8	94,97	CD4	23,26	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY releases|dobj|cells releases|nsubj|Elimination Elimination|acl|cycling cycling|dobj|cells cells|nummod|END_ENTITY	Elimination of cycling CD4 + suppressor T cells with an anti-mitotic drug releases non-cycling CD8 + T cells to cause regression of an advanced_lymphoma .
21474552	0	CD8	91,94	CD4	24,27	CD8	CD4	925	920	Gene	Gene	responses|nummod|START_ENTITY induction|nmod|responses deficiency|nmod|induction deficiency|compound|END_ENTITY	IL-15 ex vivo overcomes CD4 + T cell deficiency for the induction of human antigen-specific CD8 + T cell responses .
21490785	0	CD8	0,3	CD4	113,116	CD8	CD4	925	920	Gene	Gene	T-Cell|compound|START_ENTITY Responses|nsubj|T-Cell Responses|nmod|Adults Adults|acl:relcl|Initiated Initiated|dobj|ART ART|nmod|< <|compound|END_ENTITY	CD8 T-Cell Responses before and after Structured Treatment Interruption in Ugandan Adults Who Initiated ART with CD4 T Cells < 200 Cell / L : The DART Trial STI Substudy .
21502514	0	CD8	37,40	CD4	0,3	CD8	CD4	925	920	Gene	Gene	differentiation|compound|START_ENTITY control|dobj|differentiation control|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasis .
21518973	0	CD8	67,70	CD4	0,3	CD8	CD4	925	920	Gene	Gene	lung_inflammation|compound|START_ENTITY dispensable|nmod|lung_inflammation +|ccomp|dispensable +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
21611103	0	CD8	20,23	CD4	15,18	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dual-Positive -LRB- CD4 + / CD8 + -RRB- Acute Adult_T-Cell_Leukemia / Lymphoma Associated with Complex Karyotype and Refractory Hypercalcemia : Case Report and Literature Review .
21622860	0	CD8	53,56	CD4	10,13	CD8	CD4	925	920	Gene	Gene	responses|nummod|START_ENTITY +|nmod|responses +|nsubj|END_ENTITY	Cytotoxic CD4 + T cell responses to EBV contrast with CD8 responses in breadth of lytic cycle antigen choice and in lytic cycle recognition .
21652515	0	CD8	91,94	CD4	0,3	CD8	CD4	925	920	Gene	Gene	CD28-CTL|compound|START_ENTITY activity|nmod|CD28-CTL enhance|dobj|activity +|ccomp|enhance +|nsubj|FoxP3 FoxP3|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
21738737	0	CD8	54,57	CD4	91,94	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells triggered|nsubj|induction triggered|nmod|responses responses|compound|END_ENTITY	Physiological induction of regulatory Qa-1-restricted CD8 + T cells triggered by endogenous CD4 + T cell responses .
21809071	0	CD8	81,84	CD4	76,79	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Good response to HBsAg vaccine in dialysis patients is associated with high CD4 + / CD8 + ratio .
21858238	0	CD8	102,105	CD4	98,101	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chagasic thymic atrophy does not affect negative selection but results in the export of activated CD4 + CD8 + T cells in severe forms of human disease .
21881481	0	CD8	10,13	CD4	36,39	CD8	CD4	925	920	Gene	Gene	T-cell|compound|START_ENTITY Impact|nmod|T-cell activation|nsubj|Impact activation|nmod|T-cell T-cell|compound|END_ENTITY	Impact of CD8 + T-cell activation on CD4 + T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy .
21886854	0	CD8	15,18	CD4	10,13	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	Increased CD4 + / CD8 + double-positive T cells in chronic Chagasic patients .
21919996	0	CD8	80,83	CD4	41,44	CD8	CD4	925	920	Gene	Gene	T-cell|compound|START_ENTITY T-cell|dep|influencing influencing|dobj|normalization normalization|nmod|+ +|compound|END_ENTITY	Factors influencing the normalization of CD4 + T-cell count , percentage and CD4 + / CD8 + T-cell ratio in HIV-infected patients on long-term suppressive antiretroviral therapy .
22002875	0	CD8	25,28	CD4	102,105	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY model|nmod|cells model|dep|killing killing|nmod|cells cells|compound|END_ENTITY	A clonal model for human CD8 + regulatory T cells : unrestricted contact-dependent killing of activated CD4 + T cells .
22051534	0	CD8	125,128	CD4	121,124	CD8	CD4	925	920	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Notch induces human T-cell receptor y + thymocytes to differentiate along a parallel , highly proliferative and bipotent CD4 CD8 double-positive pathway .
22067371	0	CD8	57,60	CD4	53,56	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY Differences|dep|ratio Differences|nmod|status status|nmod|END_ENTITY	Differences according to gender and health status in CD4 : CD8 ratio in a sample of community-dwelling oldest old .
22116827	0	CD8	59,62	CD4	7,10	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY induce|nmod|cells induce|nsubj|cells cells|compound|END_ENTITY	Memory CD4 T cells induce selective expression of IL-27 in CD8 + dendritic cells and regulate homeostatic naive T cell proliferation .
22160724	0	CD8	51,54	CD4	17,20	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY exhausted|dobj|cells help|ccomp|exhausted help|nsubj|T-cell T-cell|compound|END_ENTITY	Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral_infection .
22190592	0	CD8	122,125	CD4	118,121	CD8	CD4	925	920	Gene	Gene	ratios|nummod|START_ENTITY END_ENTITY|dep|ratios	Expansion of a CD8 -LRB- + -RRB- PD-1 -LRB- + -RRB- replicative senescence phenotype in early stage CLL patients is associated with inverted CD4 : CD8 ratios and disease progression .
22190592	0	CD8	15,18	CD4	118,121	CD8	CD4	925	920	Gene	Gene	PD-1|compound|START_ENTITY Expansion|nmod|PD-1 replicative|nsubj|Expansion replicative|ccomp|associated associated|nmod|END_ENTITY	Expansion of a CD8 -LRB- + -RRB- PD-1 -LRB- + -RRB- replicative senescence phenotype in early stage CLL patients is associated with inverted CD4 : CD8 ratios and disease progression .
22373353	0	CD8	68,71	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|amod|START_ENTITY cytotoxicity|nmod|cells suppress|dobj|cytotoxicity cells|dep|suppress FoxP3|dobj|cells FoxP3|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress cytotoxicity of CD8 -LRB- + -RRB- effector T cells : implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level .
22393155	0	CD8	24,27	CD4	60,63	CD8	CD4	925	920	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|differ differ|nmod|dependence dependence|nmod|help help|compound|END_ENTITY	MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse_polyomavirus_infection .
22422886	0	CD8	122,125	CD4	161,164	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY loss|nmod|T IL-12-mediated|dep|loss memory|amod|IL-12-mediated prevents|dobj|memory prevents|nmod|absence absence|nmod|T T|compound|END_ENTITY	CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8 -LRB- + -RRB- T cell memory in the absence of CD4 -LRB- + -RRB- T cell help .
22461689	0	CD8	4,7	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + CD8 + T cells represent a significant portion of the anti-HIV T cell response to acute_HIV_infection .
22499005	0	CD8	13,16	CD4	9,12	CD8	CD4	925	920	Gene	Gene	T-lymphocyte|compound|START_ENTITY T-lymphocyte|compound|END_ENTITY	Study of CD4 + CD8 + double positive T-lymphocyte phenotype and function in Indian patients infected with HIV-1 .
22609353	0	CD8	64,67	CD4	60,63	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22640559	0	CD8	71,74	CD4	67,70	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4 + CD8 + thymocytes .
22688448	0	CD8	43,46	CD4	38,41	CD8	CD4	925	920	Gene	Gene	weak|dep|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|dep|weak T-cell_large_granular_lymphocytic_leukemia|compound|END_ENTITY	Monoclonal_B-cell_lymphocytosis -LRB- MBL , CD4 + / CD8 weak T-cell_large_granular_lymphocytic_leukemia -LRB- T-LGL_leukemia -RRB- and monoclonal_gammopathy_of_unknown_significance -LRB- MGUS -RRB- : molecular and flow cytometry characterization of three concomitant hematological_disorders .
22691754	0	CD8	138,141	CD4	129,132	CD8	CD4	925	920	Gene	Gene	In-Vitro|compound|START_ENTITY Ratio|dep|In-Vitro Ratio|nmod|Molecules Molecules|nmod|+ +|compound|END_ENTITY	Evaluation of Ginger -LRB- Zingiber officinale Roscoe -RRB- Bioactive Compounds in Increasing the Ratio of T-cell Surface Molecules of CD3 + CD4 + : CD3 + CD8 + In-Vitro .
22711904	0	CD8	33,36	CD4	67,70	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY capacity|nmod|cells predicts|nsubj|capacity predicts|dobj|rate rate|nmod|decline decline|compound|END_ENTITY	Antiviral inhibitory capacity of CD8 + T cells predicts the rate of CD4 + T-cell decline in HIV-1_infection .
22730529	0	CD8	24,27	CD4	73,76	CD8	CD4	925	920	Gene	Gene	genes|nummod|START_ENTITY silencing|nmod|genes silencing|nmod|differentiation differentiation|compound|END_ENTITY	Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation .
22781761	0	CD8	57,60	CD4	4,7	CD8	CD4	925	920	Gene	Gene	T-cells|compound|START_ENTITY transmitted|nmod|T-cells transmitted|nsubjpass|signal signal|compound|END_ENTITY	The CD4 T-cell help signal is transmitted from APC to CD8 T-cells via CD27-CD70 interactions .
22789871	0	CD8	11,14	CD4	7,10	CD4	CD4	403931(Tax:9615)	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Canine CD4 + CD8 + double positive T cells in peripheral blood have features of activated T cells .
22802109	0	CD8	51,54	CD4	44,47	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY use|dep|ratio use|nmod|END_ENTITY	Combined use of etanercept and MTX restores CD4 / CD8 ratio and Tregs in spleen and thymus in collagen-induced_arthritis .
22823432	0	CD8	16,19	CD4	12,15	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Extrathymic CD4 + CD8 + lymphocytes in Chagas_disease : possible relationship with an immunoendocrine imbalance .
22871805	0	CD8	69,72	CD4	20,23	CD8	CD4	925	920	Gene	Gene	functional|dep|START_ENTITY memory|amod|functional generation|nmod|memory control|dobj|generation control|nsubj|cells cells|compound|END_ENTITY	FoxP3 regulatory CD4 T cells control the generation of functional CD8 memory .
23018435	0	CD8	55,58	CD4	130,133	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY effects|nmod|cells effects|nmod|individuals individuals|nmod|recovery recovery|compound|END_ENTITY	Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery .
23029357	0	CD8	13,16	CD4	9,12	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Immature CD4 + CD8 + thymocytes are preferentially infected by measles_virus in human thymic organ cultures .
23034272	0	CD8	55,58	CD4	49,52	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY Correlation|dep|lymphocytes Correlation|nmod|load load|appos|levels levels|nmod|END_ENTITY	Correlation between viral load , plasma levels of CD4 - CD8 T lymphocytes and AIDS-related_oral_diseases : a multicentre study on 30 HIV + children in the HAART era .
23041830	0	CD8	20,23	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY cells|appos|cells helper|dobj|cells helper|nsubj|END_ENTITY	CD4 helper T cells , CD8 cytotoxic T cells , and FOXP3 -LRB- + -RRB- regulatory T cells with respect to lethal prostate_cancer .
23239806	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	reference|compound|START_ENTITY reference|compound|END_ENTITY	CD4 + CD8 + T cell reference values in the Mexico City population .
2328939	0	CD8	48,51	CD4	1,4	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY support|dobj|cells support|nsubj|cells cells|compound|END_ENTITY	-LSB- CD4 + T cells restricted by DQ not by DR support CD8 + T cells to grow -RSB- .
23321919	0	CD8	0,3	CD4	48,51	CD8	CD4	925	920	Gene	Gene	granzyme_B|compound|START_ENTITY granzyme_B|dep|injury injury|nmod|IFNy IFNy|compound|END_ENTITY	CD8 -LRB- + -RRB- granzyme_B -LRB- + -RRB- - mediated tissue injury vs. CD4 -LRB- + -RRB- IFNy -LRB- + -RRB- - mediated parasite killing in human cutaneous_leishmaniasis .
23324275	0	CD8	45,48	CD4	38,41	CD8	CD4	925	920	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Frequency of T-cell FoxP3 Treg and CD4 / CD8 PD-1 expression is related to HBeAg seroconversion in hepatitis_B patients on pegylated interferon .
23333732	0	CD8	145,148	CD4	77,80	CD8	CD4	925	920	Gene	Gene	involvement|nmod|START_ENTITY T|nmod|involvement T|dep|developed developed|nmod|CD8 CD8|compound|END_ENTITY	WITHDRAWN : The majority of T cells , including Treg cells , are developed from CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T progenitor cells without the involvement of the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage in the thymus .
23333732	0	CD8	83,86	CD4	139,142	CD8	CD4	925	920	Gene	Gene	developed|nmod|START_ENTITY T|dep|developed T|nmod|involvement involvement|nmod|CD8 CD8|compound|END_ENTITY	WITHDRAWN : The majority of T cells , including Treg cells , are developed from CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T progenitor cells without the involvement of the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage in the thymus .
23408789	0	CD8	12,15	CD4	6,9	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Local CD4 + , CD8 + and CD56 + T-lymphocite Reaction on Primary Lung_Cancer .
2346908	0	CD8	114,117	CD4	108,111	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY +|appos|- +|appos|- -|compound|END_ENTITY	Expansion of large granular lymphocytes -LRB- natural killer cells -RRB- with limited antigen expression -LRB- CD2 + , CD3 - , CD4 - , CD8 - , CD16 + , NKH-1 - -RRB- in a human immunodeficiency virus-positive homosexual man .
23562575	0	CD8	28,31	CD4	23,26	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The increased ratio of CD4 + / CD8 + was positively correlated with inflammation in hepatitis_C patients with metabolic_syndrome .
23800602	0	CD8	7,10	CD4	0,3	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY /|iobj|- /|nsubj|END_ENTITY	CD4 -LRB- - -RRB- / CD8 -LRB- - -RRB- variant of T-cell_large_granular_lymphocytic_leukemia or hepatosplenic_T-cell_lymphoma : a clinicopathologic dilemma .
23835849	0	CD8	97,100	CD4	0,3	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY suppression|nmod|responses counteract|dobj|suppression use|xcomp|counteract use|nsubj|cells cells|compound|END_ENTITY	CD4 + T helper cells use CD154-CD40 interactions to counteract T reg cell-mediated suppression of CD8 + T cell responses to influenza .
23846565	0	CD8	18,21	CD4	98,101	CD8	CD4	925	920	Gene	Gene	killing|compound|START_ENTITY Susceptibility|nmod|killing influences|nsubj|Susceptibility influences|dobj|reservoir reservoir|nmod|cells cells|compound|END_ENTITY	Susceptibility to CD8 T-cell-mediated killing influences the reservoir of latently HIV-1-infected CD4 T cells .
23858460	0	CD8	45,48	CD4	41,44	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Asymmetric thymocyte death underlies the CD4 : CD8 T-cell ratio in the adaptive immune system .
23874581	0	CD8	86,89	CD4	142,145	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY controls|nmod|induction controls|nmod|frequency frequency|nmod|ICOS ICOS|compound|END_ENTITY	Mesothelin virus-like particle immunization controls pancreatic_cancer growth through CD8 + T cell induction and reduction in the frequency of CD4 + foxp3 + ICOS - regulatory T cells .
23971203	0	CD8	59,62	CD4	54,57	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effect of T-2_toxin on percentages of CD4 + , CD8 + , CD4 + CD8 + and CD21 + lymphocytes , and mRNA expression levels of selected cytokines in porcine ileal Peyer 's patches .
24007533	0	CD8	8,11	CD4	4,7	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|dep|associated	The CD4 : CD8 ratio is associated with markers of age-associated_disease in virally suppressed HIV-infected patients with immunological recovery .
24114780	0	CD8	72,75	CD4	15,18	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY maintain|dobj|cells maintain|nsubj|cells cells|compound|END_ENTITY	Tumor-specific CD4 + T cells maintain effector and memory_tumor-specific CD8 + T cells .
24204912	0	CD8	18,21	CD4	14,17	CD8	CD4	925	920	Gene	Gene	normalization|compound|START_ENTITY Predictors|dep|normalization Predictors|nmod|END_ENTITY	Predictors of CD4 : CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy .
24222014	0	CD8	89,92	CD4	62,65	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY allocytotoxicity|nmod:poss|cells suppress|dobj|allocytotoxicity cells|acl:relcl|suppress cells|compound|END_ENTITY	Mycophenolic_acid-treated dendritic cells generate regulatory CD4 + T cells that suppress CD8 + T cells ' allocytotoxicity .
24240189	0	CD8	124,127	CD4	120,123	CD8	CD4	925	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Direct BMP2/4 signaling through BMP receptor IA regulates fetal thymocyte progenitor homeostasis and differentiation to CD4 + CD8 + double-positive cell .
24244610	0	CD8	14,17	CD4	30,33	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY ratios|nmod|+ T|nsubj|ratios T|nmod|+ +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24292234	0	CD8	97,100	CD4	125,128	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Necrotizing_lymphadenitis -LRB- NEL -RRB- is a systemic_disease characterized by blastic transformation of CD8 + cells and apoptosis of CD4 + cells .
24297179	0	CD8	115,118	CD4	110,113	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	cAMP_responsive_element_modulator|dep|START_ENTITY cAMP_responsive_element_modulator|nmod|CD8 CD8|nmod|generation generation|nmod|END_ENTITY	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
24297179	0	CD8	76,79	CD4	110,113	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|END_ENTITY	cAMP_responsive_element_modulator -LRB- CREM -RRB- a mediates chromatin remodeling of CD8 during the generation of CD3 + CD4 - CD8 - T cells .
2435832	0	CD8	79,82	CD4	73,76	CD8	CD4	925	920	Gene	Gene	expressed|advmod|START_ENTITY expressed|nmod|- -|compound|END_ENTITY	The T cell antigen receptor complex expressed on normal peripheral blood CD4 - , CD8 - T lymphocytes .
24387802	0	CD8	0,3	CD4	66,69	CD8	CD4	925	920	Gene	Gene	reactivity|compound|START_ENTITY unique|nsubj|reactivity unique|advcl|exists exists|nsubj|reactivity reactivity|compound|END_ENTITY	CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes .
24391889	0	CD8	12,15	CD4	106,109	CD8	CD4	925	920	Gene	Gene	percentages|compound|START_ENTITY predict|nsubj|percentages predict|dobj|recovery recovery|compound|END_ENTITY	Higher CD27 + CD8 + T cells percentages during suppressive antiretroviral therapy predict greater subsequent CD4 + T cell recovery in treated HIV_infection .
24504177	0	CD8	17,20	CD4	13,16	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|dep|associated	The inverted CD4 : CD8 ratio is associated with cytomegalovirus , poor cognitive and functional states in older adults .
24531173	1	CD8	39,42	CD4	34,37	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	CD4 + / CD8 + ratio and CD4 + percentage as surrogate markers for more complex immunological features .
24551107	0	CD8	43,46	CD4	9,12	CD8	CD4	925	920	Gene	Gene	response|compound|START_ENTITY suppress|dobj|response T|ccomp|suppress T|nsubj|CD8 CD8|compound|END_ENTITY	TCRy -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T cells suppress the CD8 -LRB- + -RRB- T-cell response to hepatitis_B virus peptides , and are associated with viral control in chronic hepatitis_B .
24559863	0	CD8	27,30	CD4	22,25	CD8	CD4	925	920	Gene	Gene	%|nummod|START_ENTITY utility|nmod|% utility|nmod|% %|nummod|END_ENTITY	Diagnostic utility of CD4 % : CD8 low % T-lymphocyte ratio to differentiate feline_immunodeficiency_virus _ -LRB- FIV -RRB- - infected from FIV-vaccinated cats .
24585895	0	CD8	113,116	CD4	11,14	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY clear|nsubj|cells +|advcl|clear +|nsubj|END_ENTITY	Periportal CD4 + cell infiltration increases in HIV/hepatitis _ C_virus-coinfected patients commencing ART , whereas CD8 + cells clear from the liver .
24676325	0	CD8	13,16	CD4	9,12	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY END_ENTITY|dep|ratio	Inverted CD4 : CD8 ratio is not associated with three-year mortality in a sample of community-dwelling oldest old : the OCTABAIX immune study .
24676325	11	CD8	1384,1387	CD4	1380,1383	CD8	CD4	925	920	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	This risk profile did not change when introducing the CD4 : CD8 ratio into the calculation .
2477711	0	CD8	39,42	CD4	35,38	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intrathymic signalling in immature CD4 + CD8 + thymocytes results in tyrosine phosphorylation of the T-cell_receptor_zeta_chain .
24789784	0	CD8	27,30	CD4	109,112	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nmod|infection infection|nmod|absence absence|nmod|cell cell|compound|END_ENTITY	Promotion of a subdominant CD8 T cell response during murine_gammaherpesvirus_68 infection in the absence of CD4 T cell help .
24816636	0	CD8	86,89	CD4	81,84	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Clinical , immunological and treatment-related factors associated with normalised CD4 + / CD8 + T-cell ratio : effect of na ve and memory T-cell subsets .
24920189	0	CD8	94,97	CD4	87,90	CD8	CD4	925	920	Gene	Gene	Homeostasis|compound|START_ENTITY Required|nsubjpass|Homeostasis Required|nmod|Restoration Restoration|nmod|END_ENTITY	p38_Mitogen-Activated_Protein_Kinase is Required for Electroacupuncture Restoration of CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- Homeostasis and Cytokine Expression in a Rodent Model of Surgical Trauma .
2495184	0	CD8	0,3	CD4	57,60	CD8	CD4	925	920	Gene	Gene	control|compound|START_ENTITY control|nmod|replication replication|nmod|cells cells|compound|END_ENTITY	CD8 + T lymphocyte control of HIV replication in cultured CD4 + cells varies among infected individuals .
2495346	0	CD8	36,39	CD4	0,3	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY percentage|dep|ratio percentage|nummod|END_ENTITY	CD4 percentage , CD4 number , and CD4 : CD8 ratio in HIV_infection : which to choose and how to use .
25002529	0	CD8	131,134	CD4	126,129	CD8	CD4	925	920	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The catalytic activity of the mitogen-activated protein kinase extracellular_signal-regulated_kinase_3 is required to sustain CD4 + CD8 + thymocyte survival .
2517950	0	CD8	64,67	CD4	59,62	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Generation of syngeneic anti-tumour double negative cells -LRB- CD4 - CD8 - -RRB- , with cytotoxic activity against clones of different MHC class I expression .
25216453	0	CD8	38,41	CD4	110,113	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|dep|autologous autologous|dep|cells cells|compound|END_ENTITY	PBMC of HIV-infected patients contain CD8 T cells that form conjugates with and kill HIV - _ infected autologous CD4 T cells .
2522047	0	CD8	155,158	CD4	138,141	CD8	CD4	925	920	Gene	Gene	clones|nummod|START_ENTITY +|acl|clones +|compound|END_ENTITY	Differential secretion of tumor_necrosis_factor-alpha and granulocyte/macrophage colony-stimulating factors but not interferon-gamma from CD4 + compared to CD8 + human T cell clones .
2523311	1	CD8	119,122	CD4	113,116	CD8	CD4	925	920	Gene	Gene	subset|compound|START_ENTITY Induction|appos|subset Induction|appos|- -|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD8	119,122	CD4	189,192	CD8	CD4	925	920	Gene	Gene	subset|compound|START_ENTITY Induction|appos|subset Induction|appos|+ +|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD8	195,198	CD4	113,116	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY Induction|appos|+ Induction|appos|- -|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD8	195,198	CD4	189,192	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY Induction|appos|+ Induction|appos|+ +|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2524009	0	CD8	18,21	CD4	13,16	CD8	CD4	925	920	Gene	Gene	Isolation|dep|START_ENTITY Isolation|nmod|END_ENTITY	Isolation of CD4 - CD8 - mycobacteria-reactive T lymphocyte clones from rheumatoid_arthritis synovial fluid .
25245659	0	CD8	95,98	CD4	37,40	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY regulated|advcl|cells regulated|nsubjpass|cells cells|amod|secretion secretion|nmod|T T|compound|END_ENTITY	Granzyme_B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells .
2528005	0	CD8	37,40	CD4	28,31	CD8	CD4	925	920	Gene	Gene	Adult_T_cell_leukemia|dep|START_ENTITY Adult_T_cell_leukemia|nmod|END_ENTITY	-LSB- Adult_T_cell_leukemia with CD4 - and CD8 - -RSB- .
25308332	0	CD8	65,68	CD4	0,3	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY formation|nmod|T T|dep|formation T|compound|END_ENTITY	CD4 + T cell help guides formation of CD103 + lung-resident memory CD8 + T cells during influenza viral_infection .
25350657	0	CD8	38,41	CD4	0,3	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY +|dep|ratio +|compound|END_ENTITY	CD4 + , CD8 + , CD3 + cell counts and CD4 + / CD8 + ratio among patients with mycobacterial_diseases -LRB- Leprosy , Tuberculosis -RRB- , HIV_infections and Normal Healthy Adults : A comparative analysis of studies in different regions of India .
25355885	0	CD8	47,50	CD4	0,3	CD8	CD4	925	920	Gene	Gene	Memory|compound|START_ENTITY Dispensable|nmod|Memory Dispensable|nsubj|Help Help|compound|END_ENTITY	CD4 + T Cell Help Is Dispensable for Protective CD8 + T Cell Memory against Mousepox_Virus following Vaccinia_Virus Immunization .
25357997	0	CD8	153,156	CD4	148,151	CD8	CD4	925	920	Gene	Gene	Thymocytes|dep|START_ENTITY Thymocytes|compound|END_ENTITY	A Monoclonal Antibody Against the Extracellular Domain of Mouse and Human Epithelial_V-like_Antigen_1 Reveals a Restricted Expression Pattern Among CD4 - CD8 - Thymocytes .
2535856	0	CD8	67,70	CD4	17,20	CD8	CD4	925	920	Gene	Gene	elimination|compound|START_ENTITY revealed|nmod|elimination activity|acl|revealed activity|compound|END_ENTITY	A virus-specific CD4 + cell-mediated cytolytic activity revealed by CD8 + cell elimination regularly develops in uncloned human antiviral cell lines .
25360575	0	CD8	110,113	CD4	106,109	CD8	CD4	925	920	Gene	Gene	Ratio|compound|START_ENTITY Ratio|compound|END_ENTITY	Chronic_Inflammation in a Long-Term Cohort of HIV-Infected Patients According to the Normalization of the CD4 : CD8 Ratio .
25366203	0	CD8	13,16	CD4	6,9	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD3 + , CD4 + _ CD8 + tumour infiltrating lymphocytes -LRB- TILs -RRB- are predictors of favourable survival outcome in infiltrating ductal_carcinoma of breast .
25378489	0	CD8	77,80	CD4	8,11	CD8	CD4	925	920	Gene	Gene	immunity|compound|START_ENTITY heralds|dobj|immunity heralds|nsubj|licensing licensing|compound|END_ENTITY	Cognate CD4 T-cell licensing of dendritic cells heralds anti-cytomegalovirus CD8 T-cell immunity after human allogeneic umbilical cord_blood_transplantation .
25395939	0	CD8	43,46	CD4	37,40	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY +|dep|cells +|compound|END_ENTITY	Peripheral blood lymphocyte subsets -LRB- CD4 + , CD8 + T cells -RRB- , leptin level and weight_loss after laparoscopic greater curvature plication in morbidly obese patients .
25397469	0	CD8	8,11	CD4	4,7	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|dep|associated	The CD4 : CD8 ratio is associated with IMT progression in HIV-infected patients on antiretroviral treatment .
25444817	0	CD8	66,69	CD4	0,3	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY resulting|nsubj|responses induce|dep|resulting transduced|ccomp|induce transduced|nsubj|T-cells T-cells|compound|END_ENTITY	CD4 T-cells transduced with CD80 and 4-1BBL mRNA induce long-term CD8 T-cell responses resulting in potent antitumor effects .
25454082	0	CD8	13,16	CD4	61,64	CD8	CD4	925	920	Gene	Gene	double-positive|nsubj|START_ENTITY double-positive|ccomp|develop develop|nmod|END_ENTITY	Canine CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- double-positive T cells can develop from CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
25485147	0	CD8	86,89	CD4	76,79	CD8	CD8	925	925	Gene	Gene	Ratio|compound|START_ENTITY END_ENTITY|dep|Ratio	Establishment of Normal Reference Intervals for CD3 -LRB- + -RRB- , CD4 -LRB- + -RRB- , CD8 -LRB- + -RRB- , and CD4 -LRB- + -RRB- to CD8 -LRB- + -RRB- Ratio of T Lymphocytes in HIV Negative Adults from University of Gondar Hospital , North West Ethiopia .
25488445	0	CD8	20,23	CD4	16,19	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Double positive CD4 + CD8 + T cells : key suppressive role in the production of autoantibodies in systemic_lupus_erythematosus .
2550249	0	CD8	57,60	CD4	52,55	CD8	CD4	925	920	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of T cell receptor gamma chains from adult CD4 - CD8 - thymocytes .
25536344	0	CD8	46,49	CD4	41,44	CD8	CD4	925	920	Gene	Gene	Thymocytes|compound|START_ENTITY Thymocytes|compound|END_ENTITY	T Cell Factor-1 Controls the Lifetime of CD4 + CD8 + Thymocytes In Vivo and Distal T Cell Receptor a-Chain Rearrangement Required for NKT Cell Development .
25640181	0	CD8	31,34	CD4	46,49	CD8	CD4	925	920	Gene	Gene	Lineage|compound|START_ENTITY Cross-Differentiation|nmod|Lineage Cross-Differentiation|nmod|Cells Cells|compound|END_ENTITY	Cross-Differentiation from the CD8 Lineage to CD4 T Cells in the Gut-Associated Microenvironment with a Nonessential Role of Microbiota .
2564859	0	CD8	40,43	CD4	34,37	CD8	CD4	925	920	Gene	Gene	Responsiveness|amod|START_ENTITY Responsiveness|nmod|END_ENTITY	Responsiveness of fetal and adult CD4 - , CD8 - thymocytes to T cell activation .
2570049	0	CD8	20,23	CD4	67,70	CD8	CD4	925	920	Gene	Gene	suppressor|compound|START_ENTITY Activation|nmod|suppressor T|nsubj|Activation T|nmod|line line|compound|END_ENTITY	Activation of human CD8 + suppressor T cells by an antigen-specific CD4 + T-cell line in vitro .
25715104	0	CD8	95,98	CD4	70,73	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY Influence|dep|ratio Influence|nmod|recovery recovery|nmod|count count|compound|END_ENTITY	Influence of lifelong cumulative_HIV_viremia on long-term recovery of CD4 + cell count and CD4 + / CD8 + ratio among patients on combination antiretroviral therapy .
2571681	0	CD8	16,19	CD4	12,15	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD8 + cells in myasthenia_gravis : supplementary immunological parameter for long-term prognosis .
25764310	0	CD8	133,136	CD4	76,79	CD8	CD4	925	920	Gene	Gene	T-Cell-Mediated_HIV_Suppression|compound|START_ENTITY Determined|nmod|T-Cell-Mediated_HIV_Suppression Determined|nsubj|Outcome Outcome|nmod|HIV_Viraemic_Controllers HIV_Viraemic_Controllers|nmod|Counts Counts|compound|END_ENTITY	Clinical Outcome of HIV_Viraemic_Controllers and Noncontrollers with Normal CD4 Counts Is Exclusively Determined by Antigen-Specific CD8 + T-Cell-Mediated_HIV_Suppression .
25946343	0	CD8	43,46	CD4	37,40	CD8	CD4	925	920	Gene	Gene	Cells|compound|START_ENTITY +|dep|Cells +|compound|END_ENTITY	Peripheral Blood Lymphocyte Subsets -LRB- CD4 + , CD8 + T Cells , NK Cells -RRB- in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy .
25946343	0	CD8	43,46	CD4	37,40	CD8	CD4	925	920	Gene	Gene	Cells|compound|START_ENTITY +|dep|Cells +|compound|END_ENTITY	Peripheral Blood Lymphocyte Subsets -LRB- CD4 + , CD8 + T Cells , NK Cells -RRB- in Patients with Cardiovascular and Neurological Complications after Carotid Endarterectomy .
26022412	0	CD8	0,3	CD4	31,34	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY END_ENTITY|compound|T	CD8 -LRB- + -RRB- T activation attenuates CD4 -LRB- + -RRB- T proliferation through dendritic cells modification .
26022412	0	CD8	0,3	CD4	31,34	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY END_ENTITY|compound|T	CD8 -LRB- + -RRB- T activation attenuates CD4 -LRB- + -RRB- T proliferation through dendritic cells modification .
26034206	0	CD8	36,39	CD4	0,3	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T resemble|ccomp|lymphocytes resemble|nsubj|lymphocytes lymphocytes|compound|END_ENTITY	CD4 + CD28null T lymphocytes resemble CD8 + CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients .
26051633	0	CD8	17,20	CD4	13,16	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|dep|associated	The inverted CD4 : CD8 ratio is associated with gender-related changes in oxidative stress during aging .
26116499	0	CD8	104,107	CD4	0,3	CD8	CD4	925	920	Gene	Gene	Cells|compound|START_ENTITY Blockade|nmod|Cells Potential|nmod|Blockade Augments|dobj|Potential Augments|nsubj|Substantially Substantially|compound|END_ENTITY	CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells .
26130226	0	CD8	4,7	CD4	0,3	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY END_ENTITY|dep|ratio	CD4 : CD8 ratio as a frontier marker for clinical outcome , immune_dysfunction and viral reservoir size in virologically suppressed HIV-positive patients .
26147684	0	CD8	118,121	CD4	23,26	CD8	CD4	925	920	Gene	Gene	maturation|nmod|START_ENTITY promotes|dobj|maturation promotes|nmod|Production Production|dep|cells cells|amod|END_ENTITY	Production of IL-10 by CD4 -LRB- + -RRB- regulatory T cells during the resolution of infection promotes the maturation of memory CD8 -LRB- + -RRB- T cells .
26155145	0	CD8	16,19	CD4	0,3	CD8	CD4	925	920	Gene	Gene	CD28|compound|START_ENTITY CD25|appos|CD28 CD25|compound|END_ENTITY	CD4 + CD25 -LRB- high -RRB- , CD8 + CD28 - cells and thyroid autoantibodies in breast_cancer patients .
26183926	0	CD8	113,116	CD4	85,88	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY Cells|acl:relcl|+ Expression|dep|Cells Expression|nmod|II II|nmod|T T|compound|END_ENTITY	Aberrant Expression of MHC Class II in Melanoma Attracts Inflammatory Tumor-Specific CD4 + T - Cells , Which Dampen CD8 + T-cell Antitumor Reactivity .
26191056	0	CD8	4,7	CD4	0,3	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY END_ENTITY|dep|ratio	CD4 : CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1_infection : findings from an African cohort with prospective data .
26243260	0	CD8	98,101	CD4	91,94	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Acute exacerbations of chronic_obstructive_pulmonary_disease are associated with decreased CD4 + _ CD8 + T cells and increased growth ___ differentiation_factor-15 -LRB- GDF-15 -RRB- in peripheral blood .
26243260	0	CD8	98,101	CD4	91,94	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Acute exacerbations of chronic_obstructive_pulmonary_disease are associated with decreased CD4 + _ CD8 + T cells and increased growth ___ differentiation_factor-15 -LRB- GDF-15 -RRB- in peripheral blood .
26253341	0	CD8	87,90	CD4	83,86	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Host , disease , and antiretroviral factors are associated with normalization of the CD4 : CD8 ratio after initiating antiretroviral therapy .
26260525	0	CD8	15,18	CD4	10,13	CD8	CD4	925	920	Gene	Gene	T-cell_lymphoma|dep|START_ENTITY END_ENTITY|dep|T-cell_lymphoma	Recurrent CD4 - / CD8 - peripheral T-cell_lymphoma with change in cytoarchitectural features and immunophenotype over the course of disease .
26309078	0	CD8	18,21	CD4	33,36	CD8	CD4	925	920	Gene	Gene	Conversion|nmod|START_ENTITY lineage|nsubj|Conversion lineage|nmod|cells cells|compound|END_ENTITY	Conversion of the CD8 lineage to CD4 T cells .
26315539	0	CD8	21,24	CD4	15,18	CD8	CD4	925	920	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Proportions of CD4 + , CD8 + and B cell subsets are not affected by exposure to HIV or to Cotrimoxazole prophylaxis in Malawian HIV-uninfected but exposed children .
26385221	0	CD8	46,49	CD4	42,45	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CD4 + CD28null and extra-thymic CD4 + CD8 + double positive T cells are independently associated with disease_damage in systemic_lupus_erythematosus patients .
26550040	0	CD8	41,44	CD4	95,98	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY profiling|nmod|cells shows|nsubj|profiling shows|nmod|cells cells|nummod|END_ENTITY	Genome-wide DNA methylation profiling of CD8 + T cells shows a distinct epigenetic signature to CD4 + T cells in multiple_sclerosis patients .
26632470	0	CD8	8,11	CD4	1,4	CD8	CD4	925	920	Gene	Gene	T_cell_large_granular_lymphocyte_leukemia|compound|START_ENTITY T_cell_large_granular_lymphocyte_leukemia|compound|END_ENTITY	-LSB- CD4 CD8 TCRy T_cell_large_granular_lymphocyte_leukemia associated with b - _ thalassemia minor : one case report and literature review -RSB- .
26781939	0	CD8	43,46	CD4	25,28	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY cells|nmod|T memory|nsubj|cells T|xcomp|memory T|nsubj|role role|nmod|END_ENTITY	The multifaceted role of CD4 -LRB- + -RRB- T cells in CD8 -LRB- + -RRB- T cell memory .
26896482	0	CD8	148,151	CD4	61,64	CD8	CD4	925	920	Gene	Gene	Cells|compound|START_ENTITY Differentiating|nmod|Cells Signaled|advcl|Differentiating Signaled|dobj|Transcription Transcription|compound|END_ENTITY	Pillars Article : Coreceptor Reversal in the Thymus : Signaled CD4 +8 + Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8 + T Cells .
26896482	0	CD8	99,102	CD4	61,64	CD8	CD4	925	920	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Pillars Article : Coreceptor Reversal in the Thymus : Signaled CD4 +8 + Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8 + T Cells .
26912319	0	CD8	64,67	CD4	0,3	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	Proliferation|compound|START_ENTITY Required|nmod|Proliferation Required|nsubjpass|Help Help|compound|END_ENTITY	CD4 T Cell Help via B Cells Is Required for Lymphopenia-Induced CD8 T Cell Proliferation .
26939850	0	CD8	60,63	CD4	82,85	CD8	CD4	925	920	Gene	Gene	lineage|compound|START_ENTITY lineage|nmod|cells cells|compound|END_ENTITY	Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance .
26959228	0	CD8	19,22	CD4	14,17	CD8	CD4	925	920	Gene	Gene	Counts|compound|START_ENTITY Correlate|nsubj|Counts +|parataxis|Correlate +|compound|END_ENTITY	Hierarchy Low CD4 + / CD8 + T-Cell Counts and IFN-y Responses in HIV-1 + Individuals Correlate with Active TB and/or M.tb Co-Infection .
26959354	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	CD4 + / CD8 + ratio , age , and risk of serious noncommunicable_diseases in HIV-infected adults on antiretroviral therapy .
26965634	0	CD8	70,73	CD4	66,69	CD8	CD4	925	920	Gene	Gene	stage|compound|START_ENTITY stage|compound|END_ENTITY	Interleukin-7 promotes human regulatory T cell development at the CD4 + CD8 + double-positive thymocyte stage .
27068801	0	CD8	78,81	CD4	18,21	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY T|nmod|cells T|nsubj|role role|nmod|END_ENTITY	A role for CCR5 -LRB- + -RRB- CD4 T cells in cutaneous psoriasis and for CD103 -LRB- + -RRB- CCR4 -LRB- + -RRB- CD8 Teff cells in the associated systemic_inflammation .
27088803	1	CD8	26,29	CD4	77,80	CD8	CD4	925	920	Gene	Gene	NOX2-loaded|compound|START_ENTITY vesicles|nsubj|NOX2-loaded vesicles|xcomp|inhibit inhibit|dobj|cells cells|nummod|END_ENTITY	- CD8 + Tregs release NOX2-loaded vesicles to inhibit CD4 + T cells .
2783859	0	CD8	12,15	CD4	6,9	CD8	CD4	925	920	Gene	Gene	+|appos|START_ENTITY +|appos|- -|compound|END_ENTITY	CD7 + , CD4 - , CD8 - acute leukemia : a syndrome of malignant pluripotent lymphohematopoietic cells .
2783889	6	CD8	823,826	CD4	818,821	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|dep|studied studied|ccomp|was was|nsubj|+ +|amod|reversed reversed|dep|END_ENTITY	In all the tumors studied there was a reversed CD4 + / CD8 + ratio as compared to that found in normal peripheral blood .
2787596	0	CD8	22,25	CD4	16,19	CD8	CD4	925	920	Gene	Gene	case|parataxis|START_ENTITY case|nmod|CD3 CD3|nummod|END_ENTITY	A case of CD3 + , CD4 - , CD8 - , WT31 - acute_T-cell_leukemia .
2790191	0	CD8	41,44	CD4	36,39	CD8	CD4	925	920	Gene	Gene	T-prolymphocytic|compound|START_ENTITY T-prolymphocytic|compound|END_ENTITY	Proliferative pathways in CD1 - CD3 + CD4 + CD8 + T-prolymphocytic leukemic cells : analysis with monoclonal antibodies and cytokines .
2828471	0	CD8	51,54	CD4	47,50	CD8	CD4	925	920	Gene	Gene	lymphocyte|compound|START_ENTITY lymphocyte|compound|END_ENTITY	Herpesvirus ateles immortalizes in vitro a CD3 + CD4 + CD8 + marmoset lymphocyte with NK function .
2886703	0	CD8	15,18	CD4	10,13	CD8	CD4	925	920	Gene	Gene	case|dep|START_ENTITY case|nmod|+ +|compound|END_ENTITY	A case of CD4 + / CD8 - adult T-cell_leukemia with good response to interferon-beta terminating as a CD4 + / CD8 + adult T-cell_lymphoma .
2950175	0	CD8	82,85	CD4	77,80	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Determination of co-expression of activation antigens on proliferating CD4 + , CD4 + CD8 + and CD8 + lymphocyte subsets by dual parameter flow cytometry .
2960546	0	CD8	63,66	CD4	129,132	CD8	CD4	925	920	Gene	Gene	START_ENTITY|acl:relcl|expressed expressed|nmod|+ +|compound|END_ENTITY	A novel serine proteinase -LRB- HuTSP -RRB- isolated from a cloned human CD8 + cytolytic T cell line is expressed and secreted by activated CD4 + and CD8 + lymphocytes .
2960737	0	CD8	55,58	CD4	50,53	CD8	CD4	925	920	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|mechanisms mechanisms|nmod|END_ENTITY	Analysis of signal transducing mechanisms in CD3 + CD4 - CD8 - cells expressing the putative T cell receptor gamma gene product .
2962747	0	CD8	14,17	CD4	74,77	CD8	CD4	925	920	Gene	Gene	Generation|acl|START_ENTITY has|nsubj|Generation has|dobj|requirement requirement|nmod|H4 H4|nummod|+2 +2|compound|END_ENTITY	Generation of CD8 -LRB- T8 -RRB- cytotoxic cells has a preferential requirement for CD4 +2 H4 - inducer cells .
2964483	0	CD8	112,115	CD4	107,110	CD8	CD4	925	920	Gene	Gene	thymocytes|dep|START_ENTITY thymocytes|compound|END_ENTITY	CD3-associated alpha/beta and gamma/delta heterodimeric receptors are expressed by distinct populations of CD4 - CD8 - thymocytes .
2970356	0	CD8	108,111	CD4	102,105	CD8	CD4	925	920	Gene	Gene	+|appos|START_ENTITY +|appos|END_ENTITY	Heterogeneity of lymphokine-activated killer -LRB- LAK -RRB- populations at the clonal level : both NK and CD3 + , CD4 - , CD8 - clones efficiently mediate tumor cell killing .
3108883	0	CD8	98,101	CD4	93,96	CD8	CD4	925	920	Gene	Gene	gamma|dep|START_ENTITY gamma|dep|implication implication|nmod|activity activity|nmod|END_ENTITY	The T-cell receptor gamma chain-CD3 complex : implication in the cytotoxic activity of a CD3 + CD4 - CD8 - human natural killer clone .
3110350	0	CD8	32,35	CD4	26,29	CD8	CD4	925	920	Gene	Gene	START_ENTITY|nmod|CD3 CD3|nummod|END_ENTITY	Characterization of CD3 + , CD4 - , CD8 - clones expressing the putative T cell receptor gamma gene product .
3262830	0	CD8	23,26	CD4	46,49	CD8	CD4	925	920	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|clones clones|compound|END_ENTITY	Interleukin-4 mediates CD8 induction on human CD4 + T-cell clones .
3297298	0	CD8	62,65	CD4	57,60	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	T-cell_prolymphocytic_leukemia with an unusual phenotype CD4 + CD8 + .
7479922	0	CD8	22,25	CD4	102,105	CD8	CD4	925	920	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|replication replication|nmod|cells cells|compound|END_ENTITY	Interleukin_2 induces CD8 + T cell-mediated suppression of human immunodeficiency virus replication in CD4 + T cells and this effect overrides its ability to stimulate virus expression .
7482625	0	CD8	18,21	CD4	13,16	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	A decreasing CD4 + / CD8 + ratio after one month of treatment with stanazolol in postmenopausal women .
7518369	0	CD8	33,36	CD4	62,65	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY replication|nmod|cells Inhibition|nmod|replication correlates|nsubj|Inhibition correlates|nmod|counts counts|nummod|END_ENTITY	Inhibition of HIV replication by CD8 + T cells correlates with CD4 counts and clinical stage of disease .
7518749	0	CD8	81,84	CD4	76,79	CD8	CD4	925	920	Gene	Gene	CD3|dep|START_ENTITY CD3|dep|END_ENTITY	Steel_factor -LRB- c-kit_ligand -RRB- stimulates the in vitro growth of immature CD3 - / CD4 - / CD8 - thymocytes : synergy with IL-7 .
7527813	0	CD8	75,78	CD4	70,73	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	The E2 molecule -LRB- CD99 -RRB- specifically triggers homotypic aggregation of CD4 + CD8 + thymocytes .
7528767	0	CD8	83,86	CD4	78,81	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
7529806	0	CD8	17,20	CD4	56,59	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY recognize|nsubj|cells recognize|dobj|cells cells|compound|END_ENTITY	Immunoregulatory CD8 + cells recognize antigen-activated CD4 + cells in myasthenia_gravis patients and in healthy controls .
7546905	0	CD8	113,116	CD4	30,33	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY apoptosis|nmod|+ extent|nmod|apoptosis +|nmod|extent +|nsubj|Frequency Frequency|nmod|END_ENTITY	Frequency of provirus-bearing CD4 + cells in HIV_type_1 infection correlates with extent of in vitro apoptosis of CD8 + but not of CD4 + cells .
7686224	0	CD8	25,28	CD4	90,93	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY levels|nmod|cells add|nsubj|levels add|nmod|value value|nmod|levels levels|compound|END_ENTITY	Elevated levels of CD38 + CD8 + T cells in HIV_infection add to the prognostic value of low CD4 + T cell levels : results of 6 years of follow-up .
7688021	0	CD8	22,25	CD4	18,21	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Precursors of CD3 + CD4 + CD8 + cells in the human thymus are defined by expression of CD34 .
7688270	0	CD8	0,3	CD4	112,115	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|nsubj|+ +|ccomp|correlate correlate|nmod|counts counts|nummod|END_ENTITY	CD8 + CD38 + and CD8 + DR + peripheral blood_lymphoid_subsets_of_HIV-infected intravenous drug abusers correlate with CD4 + cell counts and proliferation to mitogens .
7697540	0	CD8	31,34	CD4	74,77	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|dep|lymphocytes lymphocytes|compound|END_ENTITY	Alterations in levels of CD28 - / CD8 + suppressor cell precursor and CD45RO + / CD4 + memory T lymphocytes in the peripheral blood of multiple_sclerosis patients .
7700360	0	CD8	82,85	CD4	77,80	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Defective T-cell receptor signalling and positive selection of Vav-deficient CD4 + CD8 + thymocytes .
7706707	0	CD8	77,80	CD4	73,76	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intracellular signaling events during positive and negative selection of CD4 + CD8 + thymocytes in vitro .
7730608	0	CD8	34,37	CD4	30,33	CD8	CD4	925	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|maturation maturation|nmod|END_ENTITY	In vitro maturation of clonal CD4 + CD8 + cell lines in response to TCR engagement .
7734377	0	CD8	88,91	CD4	70,73	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY CD8|dep|+ CD8|compound|END_ENTITY	Identification of biclonal -LRB- duplex -RRB- leukaemic cells expressing either CD4 + / CD8 - or CD4 - / CD8 + from a patient with adult_T-cell_leukaemia / lymphoma .
7734377	0	CD8	88,91	CD4	83,86	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY CD8|dep|+ CD8|dep|END_ENTITY	Identification of biclonal -LRB- duplex -RRB- leukaemic cells expressing either CD4 + / CD8 - or CD4 - / CD8 + from a patient with adult_T-cell_leukaemia / lymphoma .
7790038	0	CD8	92,95	CD4	15,18	CD8	CD4	925	920	Gene	Gene	generation|nmod|START_ENTITY Requirement|nmod|generation Requirement|nmod|cells cells|compound|END_ENTITY	Requirement of CD4 + T cells and antigen-presenting_cells for primary in vitro generation of CD8 + cytotoxic T cells against Ld-binding self-peptide p2Ca .
7803265	0	CD8	49,52	CD4	44,47	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Established IL-2-dependent double-negative -LRB- CD4 - CD8 - -RRB- TCR alpha beta/CD3 + ATL cells : induction of CD4 expression .
7803265	0	CD8	49,52	CD4	99,102	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY CD4|dep|- cells|appos|CD4 cells|dep|induction induction|nmod|expression expression|compound|END_ENTITY	Established IL-2-dependent double-negative -LRB- CD4 - CD8 - -RRB- TCR alpha beta/CD3 + ATL cells : induction of CD4 expression .
7822781	0	CD8	86,89	CD4	82,85	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Specific suppression by prostaglandin_E2 of activation-induced apoptosis of human CD4 + CD8 + T lymphoblasts .
7895174	0	CD8	6,9	CD4	100,103	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY lymphocyte|nsubj|T lymphocyte|xcomp|expressed expressed|nmod|cells cells|compound|END_ENTITY	Human CD8 + T lymphocyte clones specific for T cell receptor V beta families expressed on autologous CD4 + T cells .
7901153	0	CD8	97,100	CD4	0,3	CD8	CD4	925	920	Gene	Gene	line|compound|START_ENTITY activation|nmod|line comodulated|nmod|activation comodulated|nsubjpass|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7901153	0	CD8	97,100	CD4	92,95	CD8	CD4	925	920	Gene	Gene	line|compound|START_ENTITY line|compound|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7902564	0	CD8	215,218	CD4	211,214	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Decreased signaling competence as a result of receptor overexpression : overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4 + CD8 + thymocytes .
7904456	0	CD8	78,81	CD4	74,77	CD8	CD4	403158(Tax:9031)	395362(Tax:9031)	Gene	Gene	ratio|nummod|START_ENTITY END_ENTITY|dep|ratio	Genetic analysis of four differing traits -LRB- MHC haplotype , tumor response , CD4 : CD8 ratio , ev 17 -RRB- in CB and CC congenic chickens .
7905840	0	CD8	82,85	CD4	62,65	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY double|nsubj|+ expression|parataxis|double expression|nmod|+ +|compound|END_ENTITY	Differential expression of PKC_alpha and PKC_beta isozymes in CD4 + , CD8 + and CD4 + / CD8 + double positive human T cells .
7907838	0	CD8	108,111	CD4	89,92	CD8	CD4	925	920	Gene	Gene	Accuracy|dep|START_ENTITY Accuracy|nmod|method method|acl|obtaining obtaining|dobj|counts counts|compound|END_ENTITY	Accuracy and cost-effectiveness of a one-tube , three-color method for obtaining absolute CD4 counts and CD4 : CD8 ratios .
7910843	0	CD8	77,80	CD4	73,76	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Thymic epithelial cells provide unique signals for positive selection of CD4 + CD8 + thymocytes in vitro .
7922370	0	CD8	113,116	CD4	93,96	CD8	CD4	925	920	Gene	Gene	responses|compound|START_ENTITY help|nmod|responses help|nsubj|need need|nmod|T-cell T-cell|compound|END_ENTITY	Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4 + T-cell help in CD8 + T-cell responses .
7930717	0	CD8	0,3	CD4	159,162	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY lymphocyte|nsubj|+ lymphocyte|parataxis|associated associated|nmod|levels levels|compound|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
7930717	0	CD8	111,114	CD4	159,162	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY associated|nsubjpass|cells associated|nmod|levels levels|compound|END_ENTITY	CD8 + lymphocyte activation at human_immunodeficiency_virus_type_1 seroconversion : development of HLA-DR + CD38 - CD8 + cells is associated with subsequent stable CD4 + cell levels .
7955559	0	CD8	58,61	CD4	53,56	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phenotypic heterogeneity of persistent expansions of CD4 + CD8 + T cells .
7966595	0	CD8	37,40	CD4	0,3	CD8	CD4	925	920	Gene	Gene	responses|nummod|START_ENTITY sustain|dobj|responses required|xcomp|sustain required|nsubjpass|cells cells|compound|END_ENTITY	CD4 + T cells are required to sustain CD8 + cytotoxic T-cell responses during chronic viral_infection .
7967733	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	granular_lymphocytic_leukemia|compound|START_ENTITY granular_lymphocytic_leukemia|compound|END_ENTITY	CD4 + CD8 + granular_lymphocytic_leukemia arising in a patient with acute_myeloblastic_leukemia .
8041724	0	CD8	113,116	CD4	109,112	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4 + CD8 + thymocytes into mature T cells .
8049648	0	CD8	76,79	CD4	71,74	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Adult_T-cell_leukemia derived from S100_beta positive double-negative -LRB- CD4 - CD8 - -RRB- T cells .
8059546	0	CD8	20,23	CD4	15,18	CD8	CD4	925	920	Gene	Gene	ratio|nummod|START_ENTITY study|dep|ratio study|nmod|END_ENTITY	A study of the CD4 : CD8 ratio in peripheral T lymphocytes of rural Papua New Guineans : a reduced ratio assessed with regard to infectious agents .
8074498	0	CD8	97,100	CD4	92,95	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY subpopulations|nsubj|+ requirement|parataxis|subpopulations requirement|nmod|cytotoxicity cytotoxicity|nmod|+ +|compound|END_ENTITY	Signal requirement for induction of MHC-unrestricted antitumor cytotoxicity of human T cell CD4 + / CD8 + subpopulations .
8093893	0	CD8	145,148	CD4	141,144	CD8	CD4	925	920	Gene	Gene	START_ENTITY|nmod:npmod|+ +|nummod|END_ENTITY	Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4 + CD8 - and CD4-CD8 - gamma/delta T cells .
8099013	0	CD8	25,28	CD4	20,23	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Killing of immature CD4 + CD8 + thymocytes in vivo by anti-CD3 or 5 ' - -LRB- N-ethyl -RRB- - carboxamide_adenosine is blocked by glucocorticoid_receptor antagonist RU-486 .
8100570	0	CD8	22,25	CD4	17,20	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Circulating CD3 + CD4 + CD8 + T lymphocytes in multiple_sclerosis .
8101541	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	thymocytes|dep|START_ENTITY thymocytes|compound|+ +|compound|END_ENTITY	CD4 + / CD8 - thymocytes dominate the fetal thymus treated with a combination of anti-T cell receptor-beta and anti-CD4 antibodies .
8223848	0	CD8	56,59	CD4	51,54	CD8	CD4	925	920	Gene	Gene	occurrence|dep|START_ENTITY occurrence|nmod|expansion expansion|nmod|END_ENTITY	Frequent occurrence of in vivo clonal expansion of CD4 - CD8 - T cells bearing T cell receptor alpha beta chains in adult humans .
8231237	0	CD8	100,103	CD4	128,131	CD8	CD4	925	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Cyclophosphamide treatment of an SJL murine B-cell_lymphoma increases the proportion of suppressive CD8 + over tumor-stimulatory CD4 + T-lymphocytes .
8244326	0	CD8	91,94	CD4	83,86	CD8	CD4	925	920	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	Small_lymphocytic_non-Hodgkin 's _ lymphoma of suppressor/cytotoxic T-cell phenotype -LSB- CD4 -LRB- - -RRB- , CD8 -LRB- + -RRB- -RSB- .
8260458	0	CD8	126,129	CD4	122,125	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Function of alpha beta TCR + intestinal intraepithelial lymphocytes : Th1 - and Th2-type cytokine production by CD4 + CD8 - and CD4 + CD8 + T cells for helper activity .
8289789	0	CD8	57,60	CD4	33,36	CD8	CD4	925	920	Gene	Gene	T|amod|START_ENTITY cells|dep|T +|dobj|cells +|nsubj|expression expression|nmod|gene gene|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD8	57,60	CD4	52,55	CD8	CD4	925	920	Gene	Gene	T|amod|START_ENTITY cells|dep|T +|dobj|cells +|nsubj|expression expression|nmod|gene gene|nmod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD8	57,60	CD4	75,78	CD8	CD4	925	920	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD8	80,83	CD4	33,36	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY cells|dep|T +|dobj|cells +|nsubj|expression expression|nmod|gene gene|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD8	80,83	CD4	52,55	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY cells|dep|T +|dobj|cells +|nsubj|expression expression|nmod|gene gene|nmod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD8	80,83	CD4	75,78	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8294878	0	CD8	26,29	CD4	22,25	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Negative selection of CD4 + CD8 + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 .
8364204	0	CD8	30,33	CD4	25,28	CD8	CD4	925	920	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Persistent expansions of CD4 + CD8 + peripheral blood T cells .
8370171	0	CD8	58,61	CD4	53,56	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY /|compound|cells /|amod|END_ENTITY	Intrathyroidal lymphocyte subsets , including unusual CD4 + CD8 + cells and CD3loTCR alpha beta lo / - CD4-CD8 - cells , in autoimmune_thyroid_disease .
8381310	0	CD8	22,25	CD4	17,20	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Double-negative -LRB- CD4 - CD8 - -RRB- T cells from adult_T-cell_leukemia patients also have poor expression of the T-cell_receptor alpha beta/CD3 complex .
8415641	0	CD8	21,24	CD4	17,20	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Precommitment of CD4 + CD8 + thymocytes to either CD4 or CD8 lineages .
8415641	0	CD8	21,24	CD4	47,50	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY Precommitment|nmod|+ thymocytes|nsubj|Precommitment thymocytes|nmod|lineages lineages|compound|END_ENTITY	Precommitment of CD4 + CD8 + thymocytes to either CD4 or CD8 lineages .
8461016	0	CD8	76,79	CD4	71,74	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Cytofluorimetric identification of two populations of double positive -LRB- CD4 + , CD8 + -RRB- T lymphocytes in human peripheral blood .
8556507	0	CD8	160,163	CD4	155,158	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD8	160,163	CD4	32,35	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY level|nmod|lymphocytes prompted|nmod|level prompted|nsubj|Characterization Characterization|acl|circulating circulating|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD8	37,40	CD4	155,158	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY circulating|dobj|lymphocytes Characterization|acl|circulating prompted|nsubj|Characterization prompted|nmod|level level|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD8	37,40	CD4	32,35	CD8	CD4	925	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|nummod|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8630734	0	CD8	43,46	CD4	39,42	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	TCR activation of ZAP70 is impaired in CD4 + CD8 + thymocytes as a consequence of intrathymic interactions that diminish available p56lck .
8634066	0	CD8	88,91	CD4	84,87	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4 + CD8 + thymocytes .
8642767	0	CD8	186,189	CD4	181,184	CD8	CD4	925	920	Gene	Gene	CD3|dep|START_ENTITY CD3|dep|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
8648101	0	CD8	59,62	CD4	55,58	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A role for calcium influx in setting the threshold for CD4 + CD8 + thymocyte negative selection .
8658050	0	CD8	90,93	CD4	85,88	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4 + CD8 + thymocytes .
8679305	0	CD8	23,26	CD4	100,103	CD8	CD4	925	920	Gene	Gene	activity|compound|START_ENTITY activity|nmod|individual individual|nmod|counts counts|compound|END_ENTITY	Delayed virus-specific CD8 + cytotoxic T lymphocyte activity in an HIV-infected individual with high CD4 + cell counts : correlations with various parameters of disease progression .
8697628	0	CD8	43,46	CD4	101,104	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY humans|dep|+ immunization|nmod|humans immunization|parataxis|restimulates restimulates|dobj|response response|compound|END_ENTITY	Peptide immunization in humans : a combined CD8 + / CD4 + T cell-targeted vaccine restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes -LRB- CTL -RRB- .
8697628	0	CD8	43,46	CD4	48,51	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY humans|dep|+ immunization|nmod|humans immunization|parataxis|restimulates restimulates|nsubj|vaccine vaccine|compound|END_ENTITY	Peptide immunization in humans : a combined CD8 + / CD4 + T cell-targeted vaccine restimulates the memory CD4 T cell response but fails to induce cytotoxic T lymphocytes -LRB- CTL -RRB- .
8737717	0	CD8	46,49	CD4	0,3	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY cytopenia|nmod|+ cytopenia|compound|END_ENTITY	CD4 cytopenia and occasional expansion of CD4 + CD8 + lymphocytes in Sj gren 's _ syndrome .
8737717	0	CD8	46,49	CD4	42,45	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 cytopenia and occasional expansion of CD4 + CD8 + lymphocytes in Sj gren 's _ syndrome .
8828739	0	CD8	38,41	CD4	86,89	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY numbers|nmod|cells predict|nsubj|numbers predict|dobj|decline decline|nmod|cells cells|compound|END_ENTITY	Increased numbers of primed activated CD8 + CD38 + CD45RO + T cells predict the decline of CD4 + T cells in HIV-1-infected patients .
8889397	0	CD8	33,36	CD4	28,31	CD8	CD4	925	920	Gene	Gene	CD4/CD8|appos|START_ENTITY CD4/CD8|appos|END_ENTITY	Reference intervals of CD3 , CD4 , CD8 , CD4/CD8 , and absolute CD4 values in Asian and Non-Asian populations .
8934573	0	CD8	98,101	CD4	94,97	CD8	CD4	925	920	Gene	Gene	differentiation|compound|START_ENTITY differentiation|compound|END_ENTITY	Unexpectedly complex regulation of CD4/CD8 coreceptor expression supports a revised model for CD4 + CD8 + thymocyte differentiation .
8958056	0	CD8	79,82	CD4	63,66	CD8	CD4	403158(Tax:9031)	395362(Tax:9031)	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ cells|nummod|END_ENTITY	Thymocyte emigration in the chicken : an over-representation of CD4 + cells over CD8 + in the periphery .
8976166	0	CD8	92,95	CD4	135,138	CD8	CD4	925	920	Gene	Gene	subset|nmod|START_ENTITY thymus|dep|subset thymocytes|amod|thymus commitment|nmod|thymocytes terminated|nsubj|commitment terminated|dobj|synthesis synthesis|compound|END_ENTITY	Lineage commitment in the thymus : only the most differentiated -LRB- TCRhibcl-2hi -RRB- subset of CD4 + CD8 + thymocytes has selectively terminated CD4 or CD8 synthesis .
8977176	0	CD8	22,25	CD4	18,21	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TCR engagement of CD4 + CD8 + thymocytes in vitro induces early aspects of positive selection , but not apoptosis .
9016884	0	CD8	126,129	CD4	191,194	CD8	CD4	925	920	Gene	Gene	differentiation|nummod|START_ENTITY differentiation|amod|due due|nmod|biosynthesis biosynthesis|nmod|coreceptor coreceptor|compound|END_ENTITY	Asynchronous coreceptor downregulation after positive thymic selection : prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor .
9022017	0	CD8	24,27	CD4	19,22	CD8	CD4	428800(Tax:9031)	395362(Tax:9031)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9022017	0	CD8	24,27	CD4	86,89	CD8	CD4	428800(Tax:9031)	395362(Tax:9031)	Gene	Gene	population|compound|START_ENTITY population|dep|inheritance inheritance|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9029083	0	CD8	32,35	CD4	14,17	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY kill|dobj|cells kill|nsubj|cells cells|compound|END_ENTITY	Cutting edge : CD4 + T cells kill CD8 + T cells via Fas/Fas _ ligand-mediated apoptosis .
9097357	0	CD8	26,29	CD4	22,25	CD8	CD4	925	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Invasive_thymoma with CD4 + CD8 + double-positive T cell lymphocytosis .
9100586	0	CD8	123,126	CD4	154,157	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|absence absence|nmod|restriction restriction|compound|END_ENTITY	Analysis of the T cell receptor V alpha repertoire in Hashimoto 's _ thyroiditis : evidence for the restricted accumulation of CD8 + T cells in the absence of CD4 + T cell restriction .
9116306	0	CD8	69,72	CD4	64,67	CD8	CD4	925	920	Gene	Gene	comobilization|dep|START_ENTITY comobilization|nmod|END_ENTITY	Granulocyte_colony-stimulating_factor-induced comobilization of CD4 - CD8 - T cells and hematopoietic progenitor cells -LRB- CD34 + -RRB- in the blood of normal donors .
9174605	0	CD8	16,19	CD4	56,59	CD8	CD4	925	920	Gene	Gene	Signals|nmod|START_ENTITY induce|nsubj|Signals induce|nmod|lineage lineage|compound|END_ENTITY	Signals through CD8 or CD4 can induce commitment to the CD4 lineage in the thymus .
9206998	0	CD8	15,18	CD4	86,89	CD8	CD4	925	920	Gene	Gene	+|nummod|START_ENTITY cytotoxic|nmod:npmod|+ response|amod|cytotoxic Induction|nmod|response requires|nsubj|Induction requires|xcomp|cognate cognate|dobj|help help|compound|END_ENTITY	Induction of a CD8 + cytotoxic T lymphocyte response by cross-priming requires cognate CD4 + T cell help .
9217273	0	CD8	43,46	CD4	38,41	CD8	CD4	925	920	Gene	Gene	subsets|nummod|START_ENTITY effect|dep|subsets effect|nmod|1,25 1,25|amod|2_vitamin_D3 2_vitamin_D3|nmod|+ +|compound|END_ENTITY	The effect of 1,25 -LRB- OH -RRB- 2_vitamin_D3 on CD4 + / CD8 + subsets of T lymphocytes in postmenopausal women .
9278294	0	CD8	96,99	CD4	66,69	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY regulated|nmod|cells regulated|nsubjpass|activity activity|nmod|cells cells|compound|END_ENTITY	Perforin-dependent cytotoxic activity and lymphokine secretion by CD4 + T cells are regulated by CD8 + T cells .
9328784	0	CD8	26,29	CD4	22,25	CD8	CD4	925	920	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	The appearance of the CD4 + CD8 + phenotype on activated T cells : possible role of antigen transfer .
9358102	0	CD8	36,39	CD4	178,181	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells marker|nsubj|expression marker|nmod|count count|compound|END_ENTITY	Elevated CD38 antigen expression on CD8 + T cells is a stronger marker for the risk of chronic HIV_disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4 + cell count , soluble immune activation markers , or combinations of HLA-DR and CD38 expression .
9366400	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	CD4 + CD8 + thymocytes are preferentially induced to die following CD45 cross-linking , through a novel apoptotic pathway .
9382889	0	CD8	52,55	CD4	48,51	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	T cell receptor -LRB- TCR -RRB- - induced death of immature CD4 + CD8 + thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation : implications for negative selection in the thymus .
9390138	0	CD8	33,36	CD4	28,31	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY Correlation|dep|cells Correlation|nmod|ratio ratio|nmod|+ +|compound|END_ENTITY	Correlation of the ratio of CD4 + / CD8 + cells in lymph_node fine needle aspiration biopsies with HIV clinical status .
9413259	0	CD8	6,9	CD4	113,116	CD8	CD4	925	920	Gene	Gene	beta|compound|START_ENTITY modulate|nsubj|beta modulate|ccomp|autoreactive autoreactive|dobj|T-cells T-cells|compound|END_ENTITY	Human CD8 + TCR-alpha beta -LRB- + -RRB- and TCR-gamma delta -LRB- + -RRB- cells modulate autologous autoreactive neuroantigen-specific CD4 + T-cells by different mechanisms .
9445068	0	CD8	157,160	CD4	38,41	CD8	CD4	925	920	Gene	Gene	activity|compound|START_ENTITY analysis|nmod|activity system|nmod|analysis lines|dep|system lines|compound|END_ENTITY	Herpesvirus_saimiri-transformed human CD4 + T-cell lines : an efficient target cell system for the analysis of human immunodeficiency virus-specific cytotoxic CD8 + T-lymphocyte activity .
9486410	0	CD8	16,19	CD4	12,15	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Circulating CD4 + CD8 + T lymphocytes in patients with Kawasaki_disease .
9499792	0	CD8	101,104	CD4	21,24	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY mediated|nmod|cells mediated|nsubjpass|killing killing|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Apoptotic killing of CD4 + T lymphocytes in HIV-1-infected PHA-stimulated PBL cultures is mediated by CD8 + LAK cells .
9516566	0	CD8	68,71	CD4	63,66	CD8	CD4	925	920	Gene	Gene	-|compound|START_ENTITY END_ENTITY|dep|-	Changes in peripheral blood double-negative T-lymphocyte -LRB- CD3 + CD4 - CD8 - -RRB- populations associated with acute cellular rejection after liver transplantation .
9551888	1	CD8	72,75	CD4	148,151	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY induce|nsubj|cells induce|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	I. Superantigen-activated CD8 cells induce unidirectional Fas-mediated apoptosis of antigen-activated CD4 cells .
9552002	0	CD8	0,3	CD4	54,57	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY cells|amod|myelin myelin|ccomp|chemoattract chemoattract|dobj|+ +|compound|END_ENTITY	CD8 + myelin peptide-specific T cells can chemoattract CD4 + myelin peptide-specific T cells : importance of IFN-inducible protein 10 .
9558078	0	CD8	33,36	CD4	27,30	CD8	CD4	925	920	Gene	Gene	cell|compound|START_ENTITY +|appos|cell +|compound|END_ENTITY	Differential capacities of CD4 + , CD8 + , and CD4-CD8 - T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18 .
9573253	0	CD8	62,65	CD4	58,61	CD8	CD4	925	920	Gene	Gene	memory|compound|START_ENTITY memory|compound|END_ENTITY	Vaccine-induced , pseudorabies_virus-specific , extrathymic CD4 + CD8 + memory T-helper cells in swine .
9596673	0	CD8	69,72	CD4	64,67	CD8	CD4	925	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|nummod|END_ENTITY	Viral superantigen-induced negative selection of TCR transgenic CD4 + CD8 + thymocytes depends on activation , but not proliferation .
9603183	0	CD8	13,16	CD4	76,79	CD8	CD4	925	920	Gene	Gene	generation|compound|START_ENTITY generation|dep|function function|nmod|cells cells|compound|END_ENTITY	Xenospecific CD8 + cytotoxic T lymphocyte generation : accessory function for CD4 + T cells and natural killer 1.1 + cells .
9649210	0	CD8	106,109	CD4	102,105	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Neoplastic thymic epithelial cells of human thymoma support T cell development from CD4-CD8 - cells to CD4 + CD8 + cells in vitro .
9681236	0	CD8	57,60	CD4	52,55	CD8	CD4	925	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Severe bactrim-induced neutropenia with reversal of CD4 + / CD8 + lymphocyte ratio : response to recombinant human granulocyte-colony_stimulating_factor -LRB- R-metHUG-CSF -RRB- .
9765450	0	CD8	23,26	CD4	50,53	CD8	CD4	925	920	Gene	Gene	naive|dep|START_ENTITY lymphocytes|amod|naive Costimulation|nmod|lymphocytes induces|nsubj|Costimulation induces|dobj|expression expression|compound|END_ENTITY	Costimulation of naive CD8 -LRB- + -RRB- lymphocytes induces CD4 expression and allows human_immunodeficiency_virus_type_1_infection .
9773872	0	CD8	54,57	CD4	110,113	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|acl|using using|dobj|expression expression|nmod|T T|compound|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9773872	0	CD8	54,57	CD4	92,95	CD8	CD4	925	920	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|acl|using using|dobj|expression expression|nummod|END_ENTITY	Quantitation of CD38 activation antigen expression on CD8 + T cells in HIV-1 infection using CD4 expression on CD4 + T lymphocytes as a biological calibrator .
9806050	0	CD8	98,101	CD4	94,97	CD8	CD4	925	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Persistent expansion , in a human_immunodeficiency_virus-infected person , of V beta-restricted CD4 + CD8 + T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha .
9820490	0	CD8	76,79	CD4	30,33	CD8	CD4	925	920	Gene	Gene	CD28|compound|START_ENTITY +|nmod|CD28 +|nsubj|suppression suppression|nmod|END_ENTITY	Specific suppression of human CD4 + Th cell responses to pig MHC antigens by CD8 + CD28 - regulatory T cells .
9855049	0	CD8	5,8	CD4	0,3	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD8 + and CD8alpha + beta - T lymphocytes in human small intestinal lamina propria .
9862094	0	CD8	60,63	CD4	0,3	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY amplification|nmod|cells orchestrate|dobj|amplification orchestrate|nsubj|cells cells|compound|END_ENTITY	CD4 + T cells orchestrate both amplification and deletion of CD8 + T cells .
9885901	0	CD8	97,100	CD4	93,96	CD8	CD4	925	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4 + CD8 + thymocytes .
9892683	0	CD8	114,117	CD4	108,111	CD8	CD4	925	920	Gene	Gene	thymocytes|amod|START_ENTITY thymocytes|amod|END_ENTITY	Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes .
9933085	0	CD8	63,66	CD4	83,86	CD8	CD4	925	920	Gene	Gene	cells|compound|START_ENTITY provide|nmod|cells provide|advcl|costimulated costimulated|nsubjpass|cells cells|compound|END_ENTITY	ICAM-1_and_B7-1 provide similar but distinct costimulation for CD8 + T cells , while CD4 + T cells are poorly costimulated by ICAM-1 .
10329842	0	CD8	58,61	CD40	37,41	CD8	CD40	925	958	Gene	Gene	cells|compound|START_ENTITY ligand|nmod|cells ligand|nsubj|Production Production|nmod|IL-4 IL-4|nmod|END_ENTITY	Production of IL-4 and expression of CD40 ligand by human CD8 T cells .
11714787	0	CD8	130,133	CD40	161,165	CD8	CD40	925	958	Gene	Gene	T|compound|START_ENTITY CTLs|nmod|T cells|amod|CTLs generate|dobj|cells generate|advcl|essential essential|nsubj|ligation ligation|compound|END_ENTITY	Lipopolysaccharide modulation of dendritic cells is insufficient to mature dendritic cells to generate CTLs from naive polyclonal CD8 + T cells in vitro , whereas CD40 ligation is essential .
11901196	0	CD8	20,23	CD40	46,50	CD8	CD40	925	958	Gene	Gene	Generation|nmod|START_ENTITY T|nsubj|Generation T|nmod|cells cells|nummod|END_ENTITY	Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells .
12242444	0	CD8	30,33	CD40	11,15	CD8	CD40	925	958	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells role|nmod|expression expression|compound|END_ENTITY	A role for CD40 expression on CD8 + T cells in the generation of CD8 + T cell memory .
12242444	0	CD8	64,67	CD40	11,15	CD8	CD40	925	958	Gene	Gene	memory|compound|START_ENTITY generation|nmod|memory role|nmod|generation role|nmod|expression expression|compound|END_ENTITY	A role for CD40 expression on CD8 + T cells in the generation of CD8 + T cell memory .
12581766	0	CD8	0,3	CD40	52,56	CD8	CD40	925	958	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|induce induce|nmod|combination combination|compound|END_ENTITY	CD8 -LRB- + -RRB- T cells induce graft vascular_occlusion in a CD40 knockout donor/recipient combination .
14647233	0	CD8	175,178	CD40	94,98	CD8	CD40	925	958	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells resulted|nmod|activation resulted|nsubj|delivery delivery|nmod|antigens antigens|nmod|cells cells|nmod|cells cells|compound|END_ENTITY	Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8 + T cells .
15004136	0	CD8	25,28	CD40	78,82	CD8	CD40	925	958	Gene	Gene	memory|compound|START_ENTITY memory|nmod|absence absence|nmod|expression expression|nummod|END_ENTITY	Cutting edge : long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells .
15004136	0	CD8	97,100	CD40	78,82	CD8	CD40	925	958	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Cutting edge : long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells .
15827964	0	CD8	73,76	CD40	28,32	CD8	CD40	925	958	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells tolerance|acl|induction tolerance|compound|END_ENTITY	Split peripheral tolerance : CD40 ligation blocks tolerance induction for CD8 T cells but not for CD4 T cells in response to intestinal antigens .
19002156	0	CD8	90,93	CD40	0,4	CD8	CD40	925	958	Gene	Gene	contributes|nmod|START_ENTITY production|acl:relcl|contributes regulates|dobj|production regulates|nsubj|END_ENTITY	CD40 regulates human dendritic cell-derived IL-7 production that , in turn , contributes to CD8 -LRB- + -RRB- T-cell antigen-specific expansion .
23853599	0	CD8	34,37	CD40	0,4	CD8	CD40	925	958	Gene	Gene	cells|compound|START_ENTITY rescues|dobj|cells rescues|nsubj|activation activation|compound|END_ENTITY	CD40 activation rescues antiviral CD8 T cells from PD-1-mediated exhaustion .
23858029	0	CD8	14,17	CD40	34,38	CD8	CD40	925	958	Gene	Gene	signals|compound|START_ENTITY signals|compound|END_ENTITY	Inhibition of CD8 + T cell-derived CD40 signals is necessary but not sufficient for Foxp3 + induced regulatory T cell generation in vivo .
23971530	0	CD8	32,35	CD40	0,4	CD8	CD40	925	958	Gene	Gene	perspective|compound|START_ENTITY END_ENTITY|dep|perspective	CD40 signaling to the rescue : A CD8 exhaustion perspective in chronic infectious_diseases .
24108445	0	CD8	33,36	CD40	95,99	CD8	CD40	925	958	Gene	Gene	expansion|nummod|START_ENTITY dependence|nmod|expansion relies|nsubj|dependence relies|nmod|signaling signaling|compound|END_ENTITY	T-cell help dependence of memory CD8 + T-cell expansion upon vaccinia_virus challenge relies on CD40 signaling .
24801648	0	CD8	76,79	CD40	0,4	CD8	CD40	925	958	Gene	Gene	T|compound|START_ENTITY apoptosis|appos|T associated|nmod|apoptosis associated|nsubjpass|expression expression|nummod|END_ENTITY	CD40 expression in renal_cell_carcinoma is associated with tumor apoptosis , CD8 -LRB- + -RRB- T cell frequency and patient survival .
9717983	0	CD8	51,54	CD40	67,71	CD8	CD40	925	958	Gene	Gene	forms|nmod|START_ENTITY expression|nmod|forms expression|nmod|cells cells|amod|END_ENTITY	Surface expression and release of soluble forms of CD8 and CD23 in CD40 - and IL-4-activated mononuclear cells from patients with Graves ' _ disease -LRB- GD -RRB- .
16971806	0	CD8	71,74	CD40_ligand	53,64	CD8	CD40 ligand	925	959	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Blood dendritic cells generated with Flt3_ligand and CD40_ligand prime CD8 + T cells efficiently in cancer patients .
11531951	0	CD8	111,114	CD45	59,63	CD8	CD45	925	5788	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|compound|END_ENTITY	Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8 + T lymphocytes .
1294962	0	CD8	29,32	CD45	10,14	CD8	CD45	925	5788	Gene	Gene	isoforms|nmod|START_ENTITY isoforms|nummod|END_ENTITY	-LSB- Study of CD45 isoforms on T CD8 lymphocytes , in the peripheral blood and the graft in patients after kidney transplantation -RSB- .
8041724	0	CD8	113,116	CD45	38,42	CD8	CD45	925	5788	Gene	Gene	thymocytes|compound|START_ENTITY differentiation|nmod|thymocytes regulate|dobj|differentiation regulate|nsubj|Engagement Engagement|nmod|domains domains|nmod|phosphatase phosphatase|compound|END_ENTITY	Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4 + CD8 + thymocytes into mature T cells .
9366400	0	CD8	5,8	CD45	65,69	CD8	CD45	925	5788	Gene	Gene	thymocytes|compound|START_ENTITY induced|nsubjpass|thymocytes induced|xcomp|die die|dobj|cross-linking cross-linking|compound|END_ENTITY	CD4 + CD8 + thymocytes are preferentially induced to die following CD45 cross-linking , through a novel apoptotic pathway .
1345895	0	CD8	39,42	CD45R	12,17	CD8	CD45R	925	5788	Gene	Gene	cells|compound|START_ENTITY switching|nmod|cells isoform|xcomp|switching isoform|nsubj|Reversal Reversal|nmod|END_ENTITY	Reversal of CD45R isoform switching in CD8 + T cells .
2482844	0	CD8	44,47	CD45R	29,34	CD8	CD45R	925	5788	Gene	Gene	subsets|compound|START_ENTITY HLA-DR|dobj|subsets HLA-DR|nsubj|loss loss|appos|END_ENTITY	Preferential loss of Leu_8 - , CD45R , HLA-DR + CD8 cell subsets during in vitro culture of mononuclear cells from human_immunodeficiency_virus_type_I -LRB- HIV -RRB- - seropositive former blood donors .
2532577	0	CD8	24,27	CD45R	28,33	CD8	CD45R	925	5788	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of the CD8 + CD45R + -LRB- 2H4 + -RRB- suppressor effector cell .
2567246	0	CD8	59,62	CD45R	35,40	CD8	CD45R	925	5788	Gene	Gene	cells|amod|START_ENTITY molecule|nmod|cells molecule|compound|END_ENTITY	Functional characterization of the CD45R -LRB- 2H4 -RRB- molecule on CD8 -LRB- T8 -RRB- cells in the autologous mixed lymphocyte reaction system .
10640739	0	CD8	104,107	CD5	0,3	CD8	CD5	925	921	Gene	Gene	thymocytes|compound|START_ENTITY activation|nmod|thymocytes up-regulates|nmod|activation up-regulates|nsubj|costimulation costimulation|compound|END_ENTITY	CD5 costimulation up-regulates the signaling to extracellular_signal-regulated_kinase activation in CD4 + CD8 + thymocytes and supports their differentiation to the CD4 lineage .
14568926	0	CD8	0,3	CD5	43,46	CD8	CD5	925	921	Gene	Gene	+|compound|START_ENTITY alpha|nsubj|+ alpha|ccomp|surface surface|ccomp|source source|nsubj|expression expression|nummod|END_ENTITY	CD8 + alpha beta + T cells that lack surface CD5 antigen expression are a major lymphotactin -LRB- XCL1 -RRB- source in peripheral blood lymphocytes .
20065997	0	CD8	42,45	CD5	109,112	CD8	CD5	925	921	Gene	Gene	cells|compound|START_ENTITY responsiveness|nmod|cells associated|nsubjpass|responsiveness associated|nmod|expression expression|compound|END_ENTITY	Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression .
24051121	0	CD8	47,50	CD5	19,22	CD8	CD5	925	921	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Down-regulation of CD5 expression on activated CD8 + T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations .
25252047	0	CD8	57,60	CD5	25,28	CD8	CD5	925	921	Gene	Gene	cells|compound|START_ENTITY downregulation|nmod|cells downregulation|nsubj|deficiency deficiency|nmod|END_ENTITY	Munc13-4 deficiency with CD5 downregulation on activated CD8 + T cells .
7586735	0	CD8	6,9	CD5	37,40	CD8	CD5	925	921	Gene	Gene	population|compound|START_ENTITY population|acl|lacking lacking|dobj|expression expression|nummod|END_ENTITY	A CD3 + CD8 + T cell population lacking CD5 antigen expression is expanded in peripheral blood of human_immunodeficiency_virus-infected patients .
8658050	0	CD8	90,93	CD5	71,74	CD8	CD5	925	921	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Heterogeneous expression of recombination activating genes and surface CD5 in CD3low CD4 + CD8 + thymocytes .
8881750	0	CD8	33,36	CD5	140,143	CD8	CD5	925	921	Gene	Gene	apoptosis|compound|START_ENTITY influence|dobj|apoptosis Factors|acl:relcl|influence Factors|dep|loss loss|nmod|maintenance maintenance|amod|molecules molecules|dep|CD28 CD28|nummod|END_ENTITY	Factors that influence activated CD8 + T-cell apoptosis in patients with acute_herpesvirus_infections : loss of costimulatory molecules CD28 , CD5 and CD6 but relative maintenance of Bax and Bcl-X expression .
9880014	0	CD8	62,65	CD5	57,60	CD8	CD5	925	921	Gene	Gene	+|compound|START_ENTITY leukocytes|nsubj|+ leukocytes|nmod|reactivation reactivation|nmod|equid_herpesvirus-1 equid_herpesvirus-1|nmod|+ +|compound|END_ENTITY	In vitro reactivation of latent equid_herpesvirus-1 from CD5 + / CD8 + leukocytes indirectly by IL-2 or chorionic gonadotrophin .
10640724	0	CD8	63,66	CD56	100,104	CD8	CD56	925	4684	Gene	Gene	cells|compound|START_ENTITY correlates|nsubj|cells correlates|nmod|expression expression|compound|END_ENTITY	Cutting edge : cytolytic effector function in human circulating CD8 + T cells closely correlates with CD56 surface expression .
11300476	0	CD8	55,58	CD56	14,18	CD8	CD56	925	4684	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	Expression of CD56 by human_papillomavirus E7-specific CD8 + cytotoxic T lymphocytes correlates with increased intracellular perforin expression and enhanced cytotoxicity against HLA-A2-matched cervical tumor cells .
11756778	0	CD8	42,45	CD56	55,59	CD8	CD56	925	4684	Gene	Gene	+|compound|START_ENTITY Epstein-Barr_virus-associated|appos|+ Epstein-Barr_virus-associated|appos|+ +|compound|END_ENTITY	Aggressive Epstein-Barr_virus-associated , CD8 + , CD30 + , CD56 + , surface CD3 - , natural killer -LRB- NK -RRB- - like cytotoxic T-cell_lymphoma .
11757730	0	CD8	32,35	CD56	20,24	CD8	CD56	925	4684	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12562330	0	CD8	58,61	CD56	112,116	CD8	CD56	925	4684	Gene	Gene	subsets|compound|START_ENTITY characterization|nmod|subsets characterization|nmod|markers markers|appos|CD57 CD57|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
14871854	0	CD8	21,24	CD56	25,29	CD8	CD56	925	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD8 + CD56 + and CD8 + CD56 - natural killer T cells specific for MUC1 mucin .
1828937	0	CD8	5,8	CD56	103,107	CD8	CD56	925	4684	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells cells|acl:relcl|lack lack|dobj|CD57 CD57|appos|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
18801082	0	CD8	0,3	CD56	6,10	CD8	CD56	925	4684	Gene	Gene	+|compound|START_ENTITY +|appos|T-cell_lymphoma T-cell_lymphoma|compound|END_ENTITY	CD8 + , CD56 + -LRB- natural killer-like -RRB- T-cell_lymphoma involving the small intestine with no evidence of enteropathy : clinicopathology and molecular study of five Japanese patients .
19328310	0	CD8	67,70	CD56	72,76	CD8	CD56	925	4684	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	-LSB- Two cases of subcutaneous panniculitis-like T-cell_lymphoma -LRB- CD4 - CD8 + CD56 - -RRB- -RSB- .
22882906	0	CD8	50,53	CD56	54,58	CD8	CD56	925	4684	Gene	Gene	accumulation|nmod|START_ENTITY +|nsubj|accumulation +|dobj|cells cells|nummod|END_ENTITY	Persistent accumulation of interferon-y-producing CD8 + CD56 + T cells in blood from patients with coronary_artery_disease .
23241021	0	CD8	42,45	CD56	47,51	CD8	CD56	925	4684	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Poikilodermatous_mycosis_fungoides with a CD8 + CD56 + immunophenotype : a case report and literature review .
23527216	0	CD8	52,55	CD56	35,39	CD8	CD56	925	4684	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Identification of cytolytic CD161 - CD56 + regulatory CD8 T cells in human peripheral blood .
24372339	0	CD8	104,107	CD56	113,117	CD8	CD56	925	4684	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	The relationship between matrix_metalloproteinases -LRB- MMP-3 , _ -8 , _ -9 -RRB- in serum and peripheral lymphocytes -LRB- CD8 -LRB- + -RRB- , CD56 -LRB- + -RRB- -RRB- in Down_syndrome children with gingivitis .
24520422	0	CD8	31,34	CD56	10,14	CD8	CD56	925	4684	Gene	Gene	cells|compound|START_ENTITY distinguish|nsubj|cells effector|acl:relcl|distinguish Levels|dep|effector Levels|nmod|TIM-3 TIM-3|compound|END_ENTITY	Levels of CD56 + TIM-3 - effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy .
25366078	0	CD8	44,47	CD56	49,53	CD8	CD56	925	4684	Gene	Gene	Phenotype|compound|START_ENTITY Phenotype|compound|END_ENTITY	Cytotoxic Variant of Mycosis Fungoides with CD8 + CD56 + Phenotype : A Case Report and Review of Literature .
25442255	0	CD8	35,38	CD56	40,44	CD8	CD56	925	4684	Gene	Gene	immunophenotype|compound|START_ENTITY immunophenotype|compound|END_ENTITY	Childhood_mycosis_fungoides with a CD8 + CD56 + cytotoxic immunophenotype .
26751040	0	CD8	42,45	CD56	49,53	CD8	CD56	925	4684	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Effect of age and latent CMV_infection on CD8 + CD56 + T cells -LRB- NKT-like -RRB- frequency and functionality .
7545096	0	CD8	126,129	CD56	239,243	CD8	CD56	925	4684	Gene	Gene	+|compound|START_ENTITY increased|dobj|+ increased|nmod|molecules molecules|appos|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7545096	0	CD8	245,248	CD56	239,243	CD8	CD56	925	4684	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
9811340	0	CD8	36,39	CD56	5,9	CD8	CD56	925	4684	Gene	Gene	CD5-T-cell_lymphomas|nummod|START_ENTITY CD5-T-cell_lymphomas|nsubj|lymphomas lymphomas|amod|END_ENTITY	Most CD56 + intestinal lymphomas are CD8 + CD5-T-cell_lymphomas of monomorphic small to medium size histology .
10025897	0	CD8	57,60	CD57	62,66	CD8	CD57	925	27087	Gene	Gene	counterpart|compound|START_ENTITY counterpart|compound|END_ENTITY	Leukemic CD3 + LGL share functional properties with their CD8 + CD57 + cell counterpart expanded after BMT .
10583606	0	CD8	102,105	CD57	90,94	CD8	CD57	925	27087	Gene	Gene	population|compound|START_ENTITY population|dep|lymphocytes lymphocytes|nmod|CD28 CD28|compound|END_ENTITY	Large clonal expansions of human virus-specific memory cytotoxic T lymphocytes within the CD57 + CD28 - CD8 + T-cell population .
10765928	0	CD8	0,3	CD57	6,10	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY cells|appos|END_ENTITY	CD8 + , CD57 + T cells from healthy elderly subjects suppress neutrophil development in vitro : implications for the neutropenia of Felty 's and large granular lymphocyte syndromes .
11757730	0	CD8	32,35	CD57	26,30	CD8	CD57	925	27087	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Association of CD4 + / CD56 + / CD57 + / CD8 + -LRB- dim -RRB- large granular_lymphocytic_leukemia , splenic_B-cell_lymphoma with circulating villous_lymphocytes , and idiopathic_erythrocytosis .
12433688	0	CD8	89,92	CD57	14,18	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY senescence|nmod|cells defines|dobj|senescence defines|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8 + T cells .
12562330	0	CD8	58,61	CD57	118,122	CD8	CD57	925	27087	Gene	Gene	subsets|compound|START_ENTITY characterization|nmod|subsets characterization|nmod|markers markers|appos|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
12562330	0	CD8	58,61	CD57	163,167	CD8	CD57	925	27087	Gene	Gene	subsets|compound|START_ENTITY characterization|nmod|subsets characterization|dep|T T|compound|END_ENTITY	Functional and Vbeta repertoire characterization of human CD8 + T-cell subsets with natural killer cell markers , CD56 + CD57 - T cells , CD56 + CD57 + T cells and CD56 - CD57 + T cells .
15879103	0	CD8	76,79	CD57	163,167	CD8	CD57	925	27087	Gene	Gene	T|compound|START_ENTITY Expression|nmod|T lymphocytes|nsubj|Expression lymphocytes|nmod|END_ENTITY	Expression of killer_cell_lectin-like_receptor_G1 on antigen-specific human CD8 + T lymphocytes during active , latent , and resolved_infection and its relation with CD57 .
16290071	6	CD8	761,764	CD57	765,769	CD8	CD57	925	27087	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CD8 + CD57 + lymphocytes in normal and HIV-infected subjects underwent more apoptosis than CD8 + CD57 - cells .
16649379	0	CD8	71,74	CD57	40,44	CD8	CD57	925	27087	Gene	Gene	T|compound|START_ENTITY subset|nmod|T subset|compound|END_ENTITY	Increased activation and expansion of a CD57 + subset within peripheral CD8 + T lymphocytes in Mycobacterium_tuberculosis-infected patients .
16805321	0	CD8	24,27	CD57	28,32	CD8	CD57	925	27087	Gene	Gene	lymphocytes|nummod|START_ENTITY lymphocytes|compound|END_ENTITY	Increase of circulating CD8 + CD57 + lymphocytes after measles_infection but not after measles vaccination .
1707006	0	CD8	44,47	CD57	48,52	CD8	CD57	925	27087	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	A lectin-binding soluble factor released by CD8 + CD57 + lymphocytes from AIDS patients inhibits T cell cytotoxicity .
1709378	0	CD8	29,32	CD57	33,37	CD8	CD57	925	27087	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	A soluble factor released by CD8 + CD57 + lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis .
17626255	0	CD8	34,37	CD57	39,43	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ expansion|parataxis|T-cell T-cell|nsubj|+ +|compound|END_ENTITY	Transient monoclonal expansion of CD8 + / CD57 + T-cell large granular lymphocytes after primary cytomegalovirus_infection .
1828385	0	CD8	21,24	CD57	25,29	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Inhibitor effect of CD8 + CD57 + lymphocytes on cell-mediated cytotoxicity : characterization of suppressor factor -RSB- .
1828937	0	CD8	5,8	CD57	109,113	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells cells|acl:relcl|lack lack|dobj|END_ENTITY	Most CD8 + cells in skin_lesions of CD3 + CD4 + mycosis_fungoides are CD3 + T cells that lack CD11b , CD16 , CD56 , CD57 , and human Hanukah factor mRNA .
19646341	0	CD8	151,154	CD57	14,18	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ activation|nmod|cells evidence|nmod|activation Expression|dep|evidence Expression|nmod|END_ENTITY	Expression of CD57 on CD8 + T lymphocytes of patients with Wegener 's _ granulomatosis and microscopic_polyangiitis : evidence for continuous activation of CD8 + cells .
19646341	0	CD8	22,25	CD57	14,18	CD8	CD57	925	27087	Gene	Gene	lymphocytes|nummod|START_ENTITY END_ENTITY|nmod|lymphocytes	Expression of CD57 on CD8 + T lymphocytes of patients with Wegener 's _ granulomatosis and microscopic_polyangiitis : evidence for continuous activation of CD8 + cells .
20385876	0	CD8	54,57	CD57	59,63	CD8	CD57	925	27087	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The small heat_shock protein 27 is a key regulator of CD8 + CD57 + lymphocyte survival .
21711350	0	CD8	15,18	CD57	20,24	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD8 + CD28 - and CD8 + CD57 + T cells and their role in health and disease .
22307139	0	CD8	52,55	CD57	58,62	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Detection and characterization of a novel subset of CD8 CD57 T cells in metastatic melanoma with an incompletely differentiated phenotype .
22789311	0	CD8	12,15	CD57	17,21	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY +|dep|T T|compound|END_ENTITY	-LSB- Polyclonal CD8 + / CD57 + T cell expansions : clinical significance -RSB- .
23355208	0	CD8	22,25	CD57	26,30	CD8	CD57	925	27087	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Expansion of a clonal CD8 + CD57 + large granular lymphocyte population after autologous stem cell transplant in multiple myeloma .
24533103	0	CD8	30,33	CD57	88,92	CD8	CD57	925	27087	Gene	Gene	response|compound|START_ENTITY improves|dobj|response improves|xcomp|SEB SEB|xcomp|due due|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	CMV latent_infection improves CD8 + T response to SEB due to expansion of polyfunctional CD57 + cells in young individuals .
24585893	0	CD8	25,28	CD57	49,53	CD8	CD57	925	27087	Gene	Gene	cells|nummod|START_ENTITY cells|acl|expressing expressing|ccomp|reversed reversed|nsubjpass|END_ENTITY	Low proportions of CD28 - CD8 + T cells expressing CD57 can be reversed by early ART initiation and predict mortality in treated HIV_infection .
24586783	0	CD8	17,20	CD57	29,33	CD8	CD57	925	27087	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Impact of HIV on CD8 + T cell CD57 expression is distinct from that of CMV and aging .
24868535	0	CD8	48,51	CD57	52,56	CD8	CD57	925	27087	Gene	Gene	expansion|compound|START_ENTITY expansion|compound|END_ENTITY	Low perceived social support is associated with CD8 + CD57 + lymphocyte expansion and increased TNF-a levels .
25100841	0	CD8	41,44	CD57	35,39	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
25100841	0	CD8	67,70	CD57	35,39	CD8	CD57	925	27087	Gene	Gene	subset|compound|START_ENTITY identifies|dobj|subset identifies|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
26761268	0	CD8	13,16	CD57	86,90	CD8	CD57	925	27087	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Correlates Correlates|nmod|Expression Expression|nmod|END_ENTITY	HIV-Specific CD8 + T Cell-Mediated Viral Suppression Correlates With the Expression of CD57 .
7511079	0	CD8	164,167	CD57	169,173	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8_lymphocytosis in primary cytomegalovirus _ -LRB- CMV -RRB- _ infection of allograft recipients : expansion of an uncommon CD8 + CD57 - subset and its progressive replacement by CD8 + CD57 + T cells .
7511468	0	CD8	9,12	CD57	13,17	CD8	CD57	925	27087	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Alveolar CD8 + CD57 + lymphocytes in human_immunodeficiency_virus_infection produce an inhibitor of cytotoxic functions .
7522602	0	CD8	41,44	CD57	45,49	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes in the level of blood suppressor CD8 + CD57 + lymphocytes , when HIV-1 p24 antigen reappears in the blood .
7525310	0	CD8	48,51	CD57	52,56	CD8	CD57	925	27087	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	An inhibitor of cytotoxic functions produced by CD8 + CD57 + T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients .
7538544	0	CD8	12,15	CD57	60,64	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY expanded|nsubjpass|cells expanded|nmod|subset subset|compound|END_ENTITY	Oligoclonal CD8 + T cells are preferentially expanded in the CD57 + subset .
7540855	0	CD8	13,16	CD57	17,21	CD8	CD57	925	27087	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion of CD8 + CD57 + T cells after allogeneic BMT is related with a low incidence of relapse and with cytomegalovirus_infection .
7561518	0	CD8	34,37	CD57	29,33	CD8	CD57	925	27087	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|expression expression|nmod|END_ENTITY	Enhanced expression of novel CD57 + CD8 + LAK cells from cats infected with feline_immunodeficiency_virus .
7682534	0	CD8	78,81	CD57	83,87	CD8	CD57	925	27087	Gene	Gene	hybridoma|compound|START_ENTITY hybridoma|compound|END_ENTITY	Purification and partial amino_acid sequence of suppressive lymphokine from a CD8 + CD57 + human T hybridoma .
7693383	0	CD8	11,14	CD57	17,21	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY +|appos|cells cells|nummod|END_ENTITY	Subsets of CD8 + , CD57 + cells in normal , healthy individuals : correlations with human_cytomegalovirus _ -LRB- HCMV -RRB- carrier status , phenotypic and functional analyses .
9013995	0	CD8	42,45	CD57	46,50	CD8	CD57	925	27087	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Clonal expansion within the CD4 + CD57 + and CD8 + CD57 + T cell subsets in chronic_lymphocytic_leukemia .
9075840	0	CD8	145,148	CD57	115,119	CD8	CD57	925	27087	Gene	Gene	compartment|compound|START_ENTITY cells|nmod|compartment response|dep|cells response|dep|mobilization mobilization|nmod|+ +|appos|cells cells|nmod|expansion expansion|nmod|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9075840	0	CD8	145,148	CD57	76,80	CD8	CD57	925	27087	Gene	Gene	compartment|compound|START_ENTITY cells|nmod|compartment response|dep|cells response|dep|mobilization mobilization|nmod|+ +|compound|END_ENTITY	Recall response to cytomegalovirus in allograft recipients : mobilization of CD57 + , CD28 + cells before expansion of CD57 + , CD28 - cells within the CD8 + T lymphocyte compartment .
9504628	0	CD8	0,3	CD57	5,9	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY +|parataxis|suppress suppress|nsubj|cells cells|compound|END_ENTITY	CD8 + / CD57 cells and apoptosis suppress T-cell functions in multiple_myeloma .
9543594	0	CD8	95,98	CD57	99,103	CD8	CD57	925	27087	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Membranoproliferative_glomerulonephritis in the aged and its possible causal relationship with CD8 + CD57 + lymphocytes .
11090146	0	CD8	61,64	CD62L	88,93	CD8	CD62L	925	20343(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Enrichment of immediate-early 1 -LRB- m123/pp89 -RRB- peptide-specific CD8 T cells in a pulmonary CD62L -LRB- lo -RRB- memory-effector cell pool during latent murine_cytomegalovirus infection of the lungs .
12496450	0	CD8	15,18	CD62L	35,40	CD8	CD62L	925	6402	Gene	Gene	cells|compound|START_ENTITY cells|nmod|phenotype phenotype|nummod|+ +|compound|END_ENTITY	IL-4-producing CD8 + T cells with a CD62L + + -LRB- bright -RRB- phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age .
12718752	0	CD8	41,44	CD62L	34,39	CD8	CD62L	925	6402	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dep|cells	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD8	41,44	CD62L	91,96	CD8	CD62L	925	6402	Gene	Gene	cells|nummod|START_ENTITY CD62L|dep|cells CD62L|dep|cells cells|compound|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD8	98,101	CD62L	34,39	CD8	CD62L	925	6402	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD8	98,101	CD62L	91,96	CD8	CD62L	925	6402	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
14978076	8	CD8	1090,1093	CD62L	1081,1086	CD8	CD62L	925	6402	Gene	Gene	cells|compound|START_ENTITY patrol|nsubj|cells patrol|advcl|seeded seeded|nmod|periphery periphery|appos|END_ENTITY	Once seeded in the periphery , naive CCR7 -LRB- + -RRB- CD62L -LRB- + -RRB- CD8 T cells patrol secondary lymphoid organs , whereas naive CCR7 -LRB- - -RRB- CD62L -LRB- - -RRB- CD8 T cells selectively migrate to peripheral tissues such as skin .
20972785	0	CD8	51,54	CD62L	38,43	CD8	CD62L	925	6402	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dobj|cells	Primed tumor-reactive multifunctional CD62L + human CD8 + T cells for immunotherapy .
12865808	0	CD8	30,33	CD69	0,4	CD8	CD69	925	969	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients .
1548145	0	CD8	56,59	CD69	23,27	CD8	CD69	925	969	Gene	Gene	endomyocardium|compound|START_ENTITY expressed|nmod|endomyocardium expressed|nsubjpass|END_ENTITY	The activation antigen CD69 is selectively expressed on CD8 + endomyocardium infiltrating T lymphocytes in human rejecting heart allografts .
18856207	0	CD8	64,67	CD69	56,60	CD8	CD69	925	969	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Evaluation of the expression of early activation marker CD69 by CD8 + lymphocytes in HIV-infected patients .
24566284	0	CD8	61,64	CD69	82,86	CD8	CD69	925	969	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	Mycobacterium_tuberculosis-specific polyfunctional cytotoxic CD8 + T cells express CD69 .
7697728	0	CD8	33,36	CD69	70,74	CD8	CD69	925	969	Gene	Gene	Accumulation|nmod|START_ENTITY Accumulation|dep|cells cells|acl:relcl|lack lack|dobj|END_ENTITY	Accumulation of immature CD3-CD4 + CD8 - single-positive cells that lack CD69 in epithelial cell tumors of the human thymus .
12594257	0	CD8	57,60	CD7	0,3	CD8	CD7	925	924	Gene	Gene	subsets|compound|START_ENTITY identifies|dobj|subsets marker|acl:relcl|identifies marker|nsubj|END_ENTITY	CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets .
1375001	0	CD8	106,109	CD7	94,97	CD8	CD7	925	924	Gene	Gene	-|compound|START_ENTITY +|appos|- +|compound|END_ENTITY	Clinical relevance of immunological dissection in T-ALL : a report on 20 cases with stem cell -LRB- CD7 + , CD4 - , CD8 - , CD1 - -RRB- phenotype .
15308569	0	CD8	40,43	CD7	13,16	CD8	CD7	925	924	Gene	Gene	START_ENTITY|nsubj|Expansion Expansion|nmod|END_ENTITY	Expansion of CD7 -LRB- low -RRB- and CD7 -LRB- negative -RRB- CD8 T-cell effector subsets in HIV-1_infection : correlation with antigenic load and reversion by antiretroviral treatment .
1696925	0	CD8	57,60	CD7	132,135	CD8	CD7	925	924	Gene	Gene	+|compound|START_ENTITY phenotype|appos|+ gastric_T-cell_lymphoma|nmod|phenotype gastric_T-cell_lymphoma|dep|expression expression|nmod|F1 F1|nummod|END_ENTITY	Primary gastric_T-cell_lymphoma of suppressor-cytotoxic -LRB- CD8 + -RRB- phenotype : discordant expression of T-cell receptor subunit beta F1 , CD7 , and CD3 antigens .
2783859	0	CD8	12,15	CD7	0,3	CD8	CD7	925	924	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	CD7 + , CD4 - , CD8 - acute leukemia : a syndrome of malignant pluripotent lymphohematopoietic cells .
8255102	0	CD8	39,42	CD71	50,54	CD8	CD71	925	7037	Gene	Gene	CD4|dep|START_ENTITY CD4|dep|END_ENTITY	Soluble CD23 and other receptors -LRB- CD4 , CD8 , CD25 , CD71 -RRB- in serum of patients with chronic_lymphocytic_leukemia .
23709688	0	CD8	28,31	CD73	23,27	CD8	CD73	925	4907	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased frequency of CD73 + CD8 + T cells of HIV-infected patients correlates with immune activation and T cell exhaustion .
24357632	0	CD8	124,127	CD73	77,81	CD8	CD73	925	4907	Gene	Gene	response|compound|START_ENTITY involved|nmod|response cells|acl|involved cells|compound|END_ENTITY	HIV `` elite controllers '' are characterized by a high frequency of memory CD8 + CD73 + T cells involved in the antigen-specific CD8 + T-cell response .
24357632	0	CD8	72,75	CD73	77,81	CD8	CD73	925	4907	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	HIV `` elite controllers '' are characterized by a high frequency of memory CD8 + CD73 + T cells involved in the antigen-specific CD8 + T-cell response .
25490556	0	CD8	55,58	CD73	0,4	CD8	CD73	925	4907	Gene	Gene	T-Cells|compound|START_ENTITY Regulation|nmod|T-Cells Dispensable|nmod|Regulation Dispensable|nsubj|END_ENTITY	CD73 Is Dispensable for the Regulation of Inflationary CD8 + T-Cells after Murine_Cytomegalovirus_Infection and Adenovirus Immunisation .
7691935	0	CD8	83,86	CD73	35,39	CD8	CD73	925	4907	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|nsubj|signal signal|acl|delivered delivered|nmod|molecule molecule|compound|END_ENTITY	Co-stimulatory signal delivered by CD73 molecule to human CD45RAhiCD45ROlo -LRB- naive -RRB- CD8 + T lymphocytes .
9280142	0	CD8	59,62	CD73	24,28	CD8	CD73	925	4907	Gene	Gene	subset|compound|START_ENTITY END_ENTITY|nmod|subset	Decreased expression of CD73 -LRB- ecto-5 ' - nucleotidase -RRB- in the CD8 + subset is associated with zinc_deficiency in human patients .
10331493	0	CD8	131,134	CD8	52,55	CD8	CD8	925	925	Gene	Gene	CD28|compound|START_ENTITY number|nmod|CD28 accounting|nmod|number Generation|dep|accounting Generation|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
10331493	0	CD8	52,55	CD8	131,134	CD8	CD8	925	925	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Generation|dep|cells Generation|dep|accounting accounting|nmod|number number|nmod|CD28 CD28|compound|END_ENTITY	Generation of CD28 - cells from long-term-stimulated CD8 + CD28 + T cells : a possible mechanism accounting for the increased number of CD8 + CD28 - T cells in HIV-1-infected patients .
11823493	0	CD8	113,116	CD8	82,85	CD8	CD8	925	925	Gene	Gene	required|nmod|START_ENTITY required|nmod|development development|nmod|thymocytes thymocytes|amod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
11823493	0	CD8	82,85	CD8	113,116	CD8	CD8	925	925	Gene	Gene	thymocytes|amod|START_ENTITY development|nmod|thymocytes required|nmod|development required|nmod|END_ENTITY	Early growth response transcription factors are required for development of CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- thymocytes to the CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- stage .
12718752	0	CD8	41,44	CD8	98,101	CD8	CD8	925	925	Gene	Gene	cells|nummod|START_ENTITY CD62L|dep|cells CD62L|dep|cells cells|compound|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12718752	0	CD8	98,101	CD8	41,44	CD8	CD8	925	925	Gene	Gene	cells|compound|START_ENTITY CD62L|dep|cells CD62L|dep|cells cells|nummod|END_ENTITY	Decreased effector memory CD45RA + CD62L - CD8 + T cells and increased central memory CD45RA - CD62L + CD8 + T cells in peripheral blood of rheumatoid_arthritis patients .
12804002	0	CD8	111,114	CD8	47,50	CD8	CD8	925	925	Gene	Gene	count|compound|START_ENTITY +|nmod|count +|nsubj|immunodeficiency_virus_infection immunodeficiency_virus_infection|nmod|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
12804002	0	CD8	47,50	CD8	111,114	CD8	CD8	925	925	Gene	Gene	immunodeficiency_virus_infection|nmod|START_ENTITY +|nsubj|immunodeficiency_virus_infection +|nmod|count count|compound|END_ENTITY	Simian immunodeficiency_virus_infection of CD4 + CD8 + T cells in a macaque with an unusually high peripheral CD4 + CD8 + T lymphocyte count .
17570460	0	CD8	131,134	CD8	21,24	CD8	CD8	925	925	Gene	Gene	lymphocytes|compound|START_ENTITY associated|nmod|lymphocytes associated|nsubjpass|response response|compound|END_ENTITY	Lower GrB + CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes .
17570460	0	CD8	21,24	CD8	131,134	CD8	CD8	925	925	Gene	Gene	response|compound|START_ENTITY associated|nsubjpass|response associated|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Lower GrB + CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes .
18953723	0	CD8	15,18	CD8	99,102	CD8	CD8	925	925	Gene	Gene	T-lymphocytes|compound|START_ENTITY compensate|nsubj|T-lymphocytes compensate|nmod|loss loss|nmod|T-cells T-cells|compound|END_ENTITY	Non-regulatory CD8 + CD45RO + CD25 + T-lymphocytes may compensate for the loss of antigen-inexperienced CD8 + CD45RA + T-cells in old age .
18953723	0	CD8	99,102	CD8	15,18	CD8	CD8	925	925	Gene	Gene	T-cells|compound|START_ENTITY loss|nmod|T-cells compensate|nmod|loss compensate|nsubj|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Non-regulatory CD8 + CD45RO + CD25 + T-lymphocytes may compensate for the loss of antigen-inexperienced CD8 + CD45RA + T-cells in old age .
1911543	0	CD8	24,27	CD8	53,56	CD8	CD8	925	925	Gene	Gene	analysis|nmod|START_ENTITY expressed|nsubj|analysis expressed|nmod|T T|compound|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
1911543	0	CD8	53,56	CD8	24,27	CD8	CD8	925	925	Gene	Gene	T|compound|START_ENTITY expressed|nmod|T expressed|nsubj|analysis analysis|nmod|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
19609979	0	CD8	58,61	CD8	6,9	CD8	CD8	925	925	Gene	Gene	Treg|compound|START_ENTITY function|nmod|Treg have|dobj|function have|nsubj|cells cells|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
19609979	0	CD8	6,9	CD8	58,61	CD8	CD8	925	925	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|dobj|function function|nmod|Treg Treg|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
1970729	0	CD8	27,30	CD8	35,38	CD8	CD8	925	925	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD8	35,38	CD8	27,30	CD8	CD8	925	925	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
22851040	0	CD8	11,14	CD8	24,27	CD8	CD8	925	925	Gene	Gene	+|compound|START_ENTITY Balance|nmod|+ CD28|dep|Balance CD28|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
22851040	0	CD8	24,27	CD8	11,14	CD8	CD8	925	925	Gene	Gene	CD28|compound|START_ENTITY CD28|dep|Balance Balance|nmod|+ +|compound|END_ENTITY	Balance of CD8 + CD28 + / CD8 + CD28 - T lymphocytes is vital for patients with ulcerative_colitis .
24357632	0	CD8	124,127	CD8	72,75	CD8	CD8	925	925	Gene	Gene	response|compound|START_ENTITY involved|nmod|response cells|acl|involved cells|compound|END_ENTITY	HIV `` elite controllers '' are characterized by a high frequency of memory CD8 + CD73 + T cells involved in the antigen-specific CD8 + T-cell response .
24357632	0	CD8	72,75	CD8	124,127	CD8	CD8	925	925	Gene	Gene	cells|compound|START_ENTITY cells|acl|involved involved|nmod|response response|compound|END_ENTITY	HIV `` elite controllers '' are characterized by a high frequency of memory CD8 + CD73 + T cells involved in the antigen-specific CD8 + T-cell response .
25100841	0	CD8	41,44	CD8	67,70	CD8	CD8	925	925	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells identifies|nsubj|expression identifies|dobj|subset subset|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
25100841	0	CD8	67,70	CD8	41,44	CD8	CD8	925	925	Gene	Gene	subset|compound|START_ENTITY identifies|dobj|subset identifies|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
2523311	1	CD8	119,122	CD8	195,198	CD8	CD8	925	925	Gene	Gene	subset|compound|START_ENTITY Induction|appos|subset Induction|appos|+ +|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
2523311	1	CD8	195,198	CD8	119,122	CD8	CD8	925	925	Gene	Gene	+|compound|START_ENTITY Induction|appos|+ Induction|appos|subset subset|compound|END_ENTITY	Induction and characterization of a novel CD3 + , CD4 - , CD8 + T cell subset from phytohemagglutinin-stimulated patient 's CD3 + , CD4 + , CD8 + leukemic T cells .
25548225	0	CD8	112,115	CD8	40,43	CD8	CD8	925	925	Gene	Gene	Promoter|compound|START_ENTITY Foxp3|nmod|Promoter Methylation|nmod|Foxp3 Methylation|nmod|Binding Binding|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
25548225	0	CD8	40,43	CD8	112,115	CD8	CD8	925	925	Gene	Gene	Binding|compound|START_ENTITY Methylation|nmod|Binding Methylation|nmod|Foxp3 Foxp3|nmod|Promoter Promoter|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
26896482	0	CD8	148,151	CD8	99,102	CD8	CD8	925	925	Gene	Gene	Cells|compound|START_ENTITY Differentiating|nmod|Cells Signaled|advcl|Differentiating Signaled|dobj|Transcription Transcription|compound|END_ENTITY	Pillars Article : Coreceptor Reversal in the Thymus : Signaled CD4 +8 + Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8 + T Cells .
26896482	0	CD8	99,102	CD8	148,151	CD8	CD8	925	925	Gene	Gene	Transcription|compound|START_ENTITY Signaled|dobj|Transcription Signaled|advcl|Differentiating Differentiating|nmod|Cells Cells|compound|END_ENTITY	Pillars Article : Coreceptor Reversal in the Thymus : Signaled CD4 +8 + Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8 + T Cells .
7545096	0	CD8	126,129	CD8	245,248	CD8	CD8	925	925	Gene	Gene	+|compound|START_ENTITY increased|dobj|+ increased|nmod|molecules molecules|appos|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7545096	0	CD8	245,248	CD8	126,129	CD8	CD8	925	925	Gene	Gene	+|compound|START_ENTITY molecules|appos|+ increased|nmod|molecules increased|dobj|+ +|compound|END_ENTITY	Depression in caregivers of demented patients is associated with altered immunity : impaired proliferative capacity , increased CD8 + , and a decline in lymphocytes with surface signal transduction molecules -LRB- CD38 + -RRB- and a cytotoxicity marker -LRB- CD56 + CD8 + -RRB- .
7692057	0	CD8	28,31	CD8	42,45	CD8	CD8	925	925	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Type D SRV-2 virus-specific CD8 + and CD4 - CD8 - T cells that regulate virus-induced T cell proliferation in Celebes macaques .
7692057	0	CD8	42,45	CD8	28,31	CD8	CD8	925	925	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Type D SRV-2 virus-specific CD8 + and CD4 - CD8 - T cells that regulate virus-induced T cell proliferation in Celebes macaques .
7734377	0	CD8	75,78	CD8	88,91	CD8	CD8	925	925	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Identification of biclonal -LRB- duplex -RRB- leukaemic cells expressing either CD4 + / CD8 - or CD4 - / CD8 + from a patient with adult_T-cell_leukaemia / lymphoma .
7734377	0	CD8	88,91	CD8	75,78	CD8	CD8	925	925	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Identification of biclonal -LRB- duplex -RRB- leukaemic cells expressing either CD4 + / CD8 - or CD4 - / CD8 + from a patient with adult_T-cell_leukaemia / lymphoma .
8289789	0	CD8	57,60	CD8	80,83	CD8	CD8	925	925	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8289789	0	CD8	80,83	CD8	57,60	CD8	CD8	925	925	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	Specific expression of the human CD4 gene in mature CD4 + CD8 - and immature CD4 + CD8 + T cells and in macrophages of transgenic_mice .
8556507	0	CD8	160,163	CD8	37,40	CD8	CD8	925	925	Gene	Gene	lymphocytes|compound|START_ENTITY level|nmod|lymphocytes prompted|nmod|level prompted|nsubj|Characterization Characterization|acl|circulating circulating|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
8556507	0	CD8	37,40	CD8	160,163	CD8	CD8	925	925	Gene	Gene	lymphocytes|compound|START_ENTITY circulating|dobj|lymphocytes Characterization|acl|circulating prompted|nsubj|Characterization prompted|nmod|level level|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Characterization of circulating CD4 + CD8 + lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4 + CD8 + lymphocytes .
22025728	0	CD8	72,75	CD8a	43,47	CD8	CD8a	925	925	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Cd8 enhancer E8I and Runx factors regulate CD8a expression in activated CD8 + T cells .
9022017	0	CD8	24,27	CD8alpha	63,71	CD8	CD8alpha	428800(Tax:9031)	428800(Tax:9031)	Gene	Gene	population|compound|START_ENTITY population|dep|inheritance inheritance|nmod|expression expression|amod|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
10848781	0	CD8	74,77	CD94	66,70	CD8	CD94	925	3824	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Increased expression of non-functional killer inhibitory receptor CD94 in CD8 + cells of myeloma patients .
15517612	0	CD8	105,108	CD94	11,15	CD8	CD94	925	3824	Gene	Gene	lymphocytes|compound|START_ENTITY subsets|nmod|lymphocytes expressed|nmod|subsets END_ENTITY|parataxis|expressed	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
15517612	0	CD8	105,108	CD94	37,41	CD8	CD94	925	3824	Gene	Gene	lymphocytes|compound|START_ENTITY subsets|nmod|lymphocytes expressed|nmod|subsets CD94|parataxis|expressed CD94|dep|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
10653855	0	CD8	107,110	CD95	119,123	CD8	CD95	925	355	Gene	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	Soluble human MHC class I molecules induce soluble Fas_ligand secretion and trigger apoptosis in activated CD8 -LRB- + -RRB- Fas -LRB- CD95 -RRB- -LRB- + -RRB- T lymphocytes .
11165713	0	CD8	25,28	CD95	43,47	CD8	CD95	925	355	Gene	Gene	cells|nummod|START_ENTITY protects|dobj|cells protects|nmod|apoptosis apoptosis|nummod|END_ENTITY	TCR stimulation protects CD8 + T cells from CD95 mediated apoptosis .
16767155	0	CD8	65,68	CD95	0,4	CD8	CD95	925	355	Gene	Gene	thymic_lymphoma|compound|START_ENTITY apoptosis|nmod|thymic_lymphoma ligand|dobj|apoptosis ligand|nsubj|END_ENTITY	CD95 ligand mediates T-cell_receptor-induced apoptosis of a CD4 + CD8 + double positive thymic_lymphoma .
22615561	0	CD8	94,97	CD95	49,53	CD8	CD95	925	14102(Tax:10090)	Gene	Gene	response|compound|START_ENTITY accompany|dep|response accompany|amod|END_ENTITY	Pathogen-induced proapoptotic phenotype and high CD95 -LRB- Fas -RRB- expression accompany a suboptimal CD8 + T-cell response : reversal by adenoviral vaccine .
26586704	0	CD8	104,107	CD95	74,78	CD8	CD95	925	355	Gene	Gene	Lymphocytes|compound|START_ENTITY Associated|nmod|Lymphocytes Associated|nmod|Expression Expression|nmod|Perforin Perforin|nummod|END_ENTITY	Advanced Lung_Cancer Is Associated with Decreased Expression of Perforin , CD95 , CD38 by Circulating CD3 + CD8 + T Lymphocytes .
9083895	0	CD8	76,79	CD95	80,84	CD8	CD95	925	355	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8 + CD95 + , CD8 + CD38 + , and CD4 + CD95 + T cells are markers for HIV-1_infection and clinical status .
9759844	0	CD8	21,24	CD95	59,63	CD8	CD95	925	355	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|down-regulation down-regulation|dep|END_ENTITY	Superantigen-driven , CD8 + T cell-mediated down-regulation : CD95 -LRB- Fas -RRB- - dependent down-regulation of human Ig responses despite CD95-independent killing of activated B cells .
11703383	0	CD8	22,25	CLA	17,20	CD8	CLA	925	6404	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The frequency of CLA + CD8 + T cells in the blood of psoriasis patients correlates closely with the severity of their disease .
21198882	0	CD8	44,47	CLA	50,53	CD8	CLA	925	6404	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Reduction of skin-homing cytotoxic T cells -LRB- CD8 + - CLA + -RRB- in patients with vitiligo .
19247441	0	CD8	50,53	CTLA-4	89,95	CD8	CTLA-4	925	1493	Gene	Gene	cell|compound|START_ENTITY reversal|nmod|cell exhaustion|nsubj|reversal exhaustion|nmod|blockade blockade|compound|END_ENTITY	Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1 / CTLA-4 blockade .
15294933	0	CD8	71,74	CXCR1	47,52	CD8	CXCR1	925	3577	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Cutting edge : expression of chemokine receptor CXCR1 on human effector CD8 + T cells .
16081690	0	CD8	6,9	CXCR1	25,30	CD8	CXCR1	925	3577	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|store store|dobj|END_ENTITY	Human CD8 + T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation .
11918674	0	CD8	73,76	CXCR3	42,47	CD8	CXCR3	925	2833	Gene	Gene	activation|compound|START_ENTITY signalling|nmod|activation chemokine|xcomp|signalling chemokine|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of the IFN-alpha/beta-induced CXCR3 chemokine signalling for CD8 + T cell activation .
17553894	0	CD8	17,20	CXCR3	10,15	CD8	CXCR3	925	2833	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased CXCR3 + CD8 T cells in advanced human immunodeficiency_virus_infection suggest that a homing defect contributes to cytotoxic T-lymphocyte_dysfunction .
17785868	0	CD8	60,63	CXCR3	19,24	CD8	CXCR3	925	2833	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells surface|dobj|expression surface|nsubj|Down-modulation Down-modulation|nmod|END_ENTITY	Down-modulation of CXCR3 surface expression and function in CD8 + T cells from cutaneous_T_cell_lymphoma patients .
19609979	0	CD8	58,61	CXCR3	10,15	CD8	CXCR3	925	12766(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY function|nmod|Treg have|dobj|function have|nsubj|cells cells|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
19609979	0	CD8	6,9	CXCR3	10,15	CD8	CXCR3	925	12766(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
21518913	0	CD8	98,101	CXCR3	33,38	CD8	CXCR3	925	2833	Gene	Gene	generation|compound|START_ENTITY balance|nmod|generation affects|dobj|balance affects|nsubj|Expression Expression|nmod|END_ENTITY	Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation .
22111598	0	CD8	40,43	CXCR3	0,5	CD8	CXCR3	925	2833	Gene	Gene	Lymphocytes|compound|START_ENTITY Elevated|nmod|Lymphocytes Elevated|nsubj|Expression Expression|compound|END_ENTITY	CXCR3 Expression Elevated on Peripheral CD8 -LRB- + -RRB- Lymphocytes from HIV/HCV _ Coinfected Individuals .
22719212	0	CD8	106,109	CXCR3	99,104	CD8	CXCR3	925	2833	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Treatment with transcatheter arterial chemoembolization induces an increase of the L-selectin -LRB- low -RRB- CXCR3 + CD8 + T cell subset in patients with hepatocellular_carcinoma .
23065152	0	CD8	0,3	CXCR3	52,57	CD8	CXCR3	925	2833	Gene	Gene	cells|compound|START_ENTITY induce|nsubj|cells induce|dobj|migration migration|nmod|ligands ligands|nummod|END_ENTITY	CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines .
23643635	0	CD8	36,39	CXCR3	16,21	CD8	CXCR3	925	2833	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Upregulation of CXCR3 expression on CD8 + T cells due to the pervasive influence of chronic_hepatitis_B and C_virus infection .
24377099	0	CD8	147,150	CXCR3	71,76	CD8	CXCR3	925	2833	Gene	Gene	cells|compound|START_ENTITY increases|dobj|cells increases|dobj|END_ENTITY	Peptide vaccination in Montanide adjuvant induces and GM-CSF increases CXCR3 and cutaneous lymphocyte antigen expression by tumor antigen-specific CD8 T cells .
25769612	0	CD8	39,42	CXCR3	0,5	CD8	CXCR3	925	2833	Gene	Gene	T|nsubj|START_ENTITY enables|ccomp|T enables|nsubj|receptor receptor|nummod|END_ENTITY	CXCR3 chemokine receptor enables local CD8 -LRB- + -RRB- T cell migration for the destruction of virus-infected cells .
15549771	0	CD8	45,48	CXCR4	19,24	CD8	CXCR4	925	7852	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Down-regulation of CXCR4 expression on human CD8 + T cells during peripheral differentiation .
24973450	0	CD8	36,39	CXCR4	14,19	CD8	CXCR4	925	7852	Gene	Gene	self-renewal|compound|START_ENTITY critical|nmod|self-renewal self-renewal|amod|critical self-renewal|nsubj|END_ENTITY	Cutting edge : CXCR4 is critical for CD8 + memory T cell homeostatic self-renewal but not rechallenge self-renewal .
25714247	0	CD8	86,89	CXCR4	17,22	CD8	CXCR4	925	7852	Gene	Gene	Cells|compound|START_ENTITY Expansion|nmod|Cells Antagonists|xcomp|Expansion Antagonists|nsubj|END_ENTITY	HIV-1 Coreceptor CXCR4 Antagonists Promote Clonal Expansion of Viral Epitope-Specific CD8 + T Cells During Acute_SIV_Infection in Rhesus_Monkeys In Vivo .
15611250	0	CD8	43,46	CXCR6	9,14	CD8	CXCR6	925	10663	Gene	Gene	+|compound|START_ENTITY recruitment|nmod|+ END_ENTITY|nmod|recruitment	Role for CXCR6 in recruitment of activated CD8 + lymphocytes to inflamed liver .
20035869	0	CD8	23,26	CXCR6	14,19	CD8	CXCR6	925	10663	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression of CXCR6 on CD8 -LRB- + -RRB- T cells was up-regulated in allograft rejection .
24823625	0	CD8	77,80	CXCR6	23,28	CD8	CXCR6	925	10663	Gene	Gene	Specific|compound|START_ENTITY Maintenance|nmod|Specific Required|nmod|Maintenance Required|nsubjpass|END_ENTITY	The Chemokine Receptor CXCR6 Is Required for the Maintenance of Liver Memory CD8 + T Cells Specific for Infectious Pathogens .
15520172	0	CD8	49,52	CXC_chemokine_receptor_3	0,24	CD8	CXC chemokine receptor 3	925	2833	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	CXC_chemokine_receptor_3 expression by activated CD8 + T cells is associated with survival in melanoma patients with stage_III_disease .
18025165	0	CD8	89,92	Cbl-b	0,5	CD8	Cbl-b	925	868	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity .
24836425	0	CD8	115,118	Cd4	108,111	CD8	Cd4	925	920	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4 -LRB- + -RRB- T cell fate and interact with Runx3 to silence Cd4 in CD8 -LRB- + -RRB- T cells .
23536629	0	CD8	48,51	E2A	27,30	CD8	E2A	925	6929	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Id2-mediated inhibition of E2A represses memory CD8 + T cell differentiation .
14605368	0	CD8	20,23	Eomesodermin	69,81	CD8	Eomesodermin	925	8320	Gene	Gene	cell|compound|START_ENTITY Control|nmod|cell function|nsubj|Control function|nmod|END_ENTITY	Control of effector CD8 + T cell function by the transcription factor Eomesodermin .
19224637	0	CD8	47,50	Eomesodermin	80,92	CD8	Eomesodermin	925	8320	Gene	Gene	lymphocytes|compound|START_ENTITY functions|nmod|lymphocytes regulates|dobj|functions regulates|advcl|repressing repressing|dobj|END_ENTITY	CD152 -LRB- CTLA-4 -RRB- regulates effector functions of CD8 + T lymphocytes by repressing Eomesodermin .
12594270	0	CD8	26,29	FLIP	91,95	CD8	FLIP	925	8837	Gene	Gene	death|compound|START_ENTITY Inhibition|nmod|death Inhibition|dep|regulation regulation|nmod|expression expression|compound|END_ENTITY	Inhibition of TCR-induced CD8 T cell death by IL-12 : regulation of Fas_ligand and cellular FLIP expression and caspase activation by IL-12 .
15226269	0	CD8	21,24	FOXP3	31,36	CD8	FOXP3	925	50943	Gene	Gene	CD28|compound|START_ENTITY CD28|parataxis|induce induce|nsubj|cells cells|nummod|END_ENTITY	Alloantigen specific CD8 + CD28 - FOXP3 + T suppressor cells induce ILT3 + ILT4 + tolerogenic endothelial cells , inhibiting alloreactivity .
17258077	0	CD8	45,48	FOXP3	31,36	CD8	FOXP3	925	50943	Gene	Gene	IL-2-independent|dep|START_ENTITY IL-2-independent|dobj|generation generation|nmod|CD4 CD4|compound|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17414320	0	CD8	98,101	FOXP3	49,54	CD8	FOXP3	925	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells .
18089323	0	CD8	0,3	FOXP3	4,9	CD8	FOXP3	925	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD8 + FOXP3 + T cells from renal transplant recipients in quiescence induce immunoglobulin-like_transcripts-3_and _ -4 on dendritic cells from their respective donors .
18266270	0	CD8	42,45	FOXP3	55,60	CD8	FOXP3	925	50943	Gene	Gene	CD25|compound|START_ENTITY Generation|nmod|CD25 END_ENTITY|nsubj|Generation	Generation of highly suppressive adaptive CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells by continuous antigen stimulation .
18504453	0	CD8	31,34	FOXP3	4,9	CD8	FOXP3	925	50943	Gene	Gene	thymocytes|compound|START_ENTITY subset|nmod|thymocytes subset|compound|END_ENTITY	The FOXP3 + subset of human CD4 + CD8 + thymocytes is immature and subject to intrathymic selection .
19201865	0	CD8	63,66	FOXP3	57,62	CD8	FOXP3	925	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Unique phenotype of human tonsillar and in vitro-induced FOXP3 + CD8 + T cells .
20053943	0	CD8	20,23	FOXP3	13,18	CD8	FOXP3	925	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion of FOXP3 + CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian_immunodeficiency_virus infection correlates with diminished antiviral T cell response and viral control .
21996189	0	CD8	23,26	FOXP3	87,92	CD8	FOXP3	925	50943	Gene	Gene	CD28|compound|START_ENTITY CD28|parataxis|express express|dobj|protein protein|compound|END_ENTITY	Human peripheral blood CD8 + CD28 - T cells of renal allograft recipients do not express FOXP3 protein .
22267598	0	CD8	131,134	FOXP3	109,114	CD8	FOXP3	925	50943	Gene	Gene	CD4|dep|START_ENTITY ratios|appos|CD4 ratios|appos|END_ENTITY	Necrotising_enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory -LRB- FOXP3 -RRB- / effector -LRB- CD4 , CD8 -RRB- T cell ratios .
22821963	0	CD8	0,3	FOXP3	16,21	CD8	FOXP3	925	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD45RA + CCR7 + FOXP3 + T cells with immunosuppressive properties : a novel subset of inducible human regulatory T cells .
24244610	0	CD8	14,17	FOXP3	40,45	CD8	FOXP3	925	50943	Gene	Gene	+|compound|START_ENTITY ratios|nmod|+ T|nsubj|ratios T|nmod|+ +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
25202922	0	CD8	151,154	FOXP3	155,160	CD8	FOXP3	925	50943	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	HIV-1 Shedding From the Female Genital Tract is Associated With Increased Th1 Cytokines/Chemokines That Maintain Tissue Homeostasis and Proportions of CD8 + FOXP3 + T Cells .
18409287	0	CD8	44,47	Fas_Ligand	48,58	CD8	Fas Ligand	925	356	Gene	Gene	cytotoxic|compound|START_ENTITY cytotoxic|compound|END_ENTITY	-LSB- Cigarette smoking results in the number of CD8 + Fas_Ligand + T cytotoxic lymphocytes in bronchoalveolar lavage -LRB- BAL -RRB- fluid of patients with idiopathic_pulmonary_fibrosis -LRB- IPF -RRB- -RSB- .
10203105	0	CD8	31,34	Fas_ligand	91,101	CD8	Fas ligand	925	356	Gene	Gene	cells|compound|START_ENTITY proliferation|dep|cells proliferation|dep|role role|nmod|expression expression|compound|END_ENTITY	Abnormal proliferation of CD4 - CD8 + gammadelta + T cells with chromosome 6 anomaly : role of Fas_ligand expression in spontaneous regression of the cells .
10653855	0	CD8	107,110	Fas_ligand	51,61	CD8	Fas ligand	925	356	Gene	Gene	Fas|compound|START_ENTITY induce|nmod|Fas induce|dobj|secretion secretion|compound|END_ENTITY	Soluble human MHC class I molecules induce soluble Fas_ligand secretion and trigger apoptosis in activated CD8 -LRB- + -RRB- Fas -LRB- CD95 -RRB- -LRB- + -RRB- T lymphocytes .
11067907	0	CD8	53,56	Fas_ligand	0,10	CD8	Fas ligand	925	356	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells costimulates|dobj|proliferation costimulates|nsubj|END_ENTITY	Fas_ligand costimulates the in vivo proliferation of CD8 + T cells .
11555580	0	CD8	74,77	Fas_ligand	0,10	CD8	Fas ligand	925	356	Gene	Gene	lymphocytes|nummod|START_ENTITY elimination|nmod|lymphocytes mediates|dobj|elimination mediates|nsubj|expression expression|compound|END_ENTITY	Fas_ligand expression by neoplastic T lymphocytes mediates elimination of CD8 + cytotoxic T lymphocytes in mycosis fungoides : a potential mechanism of tumor immune escape ?
12594270	0	CD8	26,29	Fas_ligand	67,77	CD8	Fas ligand	925	356	Gene	Gene	death|compound|START_ENTITY Inhibition|nmod|death Inhibition|dep|regulation regulation|nmod|expression expression|compound|END_ENTITY	Inhibition of TCR-induced CD8 T cell death by IL-12 : regulation of Fas_ligand and cellular FLIP expression and caspase activation by IL-12 .
15588377	0	CD8	70,73	Fas_ligand	111,121	CD8	Fas ligand	925	356	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|express express|dobj|END_ENTITY	Intrathyroidal CD4 + T lymphocytes express high levels of Fas and CD4 + CD8 + macrophages/dendritic cells express Fas_ligand in autoimmune_thyroid_disease .
16081306	0	CD8	45,48	Fas_ligand	26,36	CD8	Fas ligand	925	356	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Tumor exosomes expressing Fas_ligand mediate CD8 + T-cell apoptosis .
16301629	0	CD8	67,70	Fas_ligand	107,117	CD8	Fas ligand	925	356	Gene	Gene	engagement|nmod|START_ENTITY lymphocytes|nmod|engagement Apoptosis|nmod|lymphocytes Fas|nsubj|Apoptosis Fas|compound|END_ENTITY	Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas_ligand / Fas mediated : evidence for the involvement of p56lck , calcium calmodulin kinase II , and Calcium-independent protein kinase C signaling pathways and for NF-kappaB and NF-AT nuclear translocation .
8566027	0	CD8	60,63	Fas_ligand	35,45	CD8	Fas ligand	925	356	Gene	Gene	clones|nummod|START_ENTITY END_ENTITY|nmod|clones	Two signaling pathways can lead to Fas_ligand expression in CD8 + cytotoxic T lymphocyte clones .
9190908	0	CD8	57,60	Fas_ligand	13,23	CD8	Fas ligand	925	356	Gene	Gene	+|compound|START_ENTITY induces|nmod|+ induces|dobj|Fas Fas|compound|END_ENTITY	IL-2 induces Fas_ligand / Fas -LRB- CD95L/CD95 -RRB- cytotoxicity in CD8 + and CD4 + T lymphocyte clones .
9817448	0	CD8	45,48	Fas_ligand	26,36	CD8	Fas ligand	925	356	Gene	Gene	T|compound|START_ENTITY mRNA|nmod|T mRNA|compound|END_ENTITY	Predominant expression of Fas_ligand mRNA in CD8 + T lymphocytes in patients with HTLV-1 associated myelopathy .
24285839	0	CD8	51,54	FcyRIIB	28,35	CD8	FcyRIIB	925	2213	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Cutting edge : Expression of FcyRIIB tempers memory CD8 T cell function in vivo .
17617596	0	CD8	106,109	FoxP3	43,48	CD8	FoxP3	925	50943	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|expansion expansion|nmod|END_ENTITY	Parallel expansion of human virus-specific FoxP3 - effector memory and de novo-generated FoxP3 + regulatory CD8 + T cells upon antigen recognition in vitro .
17898053	0	CD8	13,16	FoxP3	0,5	CD8	FoxP3	925	50943	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
19133978	0	CD8	74,77	FoxP3	13,18	CD8	FoxP3	925	50943	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dep|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19321758	0	CD8	87,90	FoxP3	69,74	CD8	FoxP3	925	50943	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|Determinants Determinants|nmod|expansion expansion|nmod|END_ENTITY	Determinants of in vitro expansion of different human virus-specific FoxP3 + regulatory CD8 + T cells in chronic_hepatitis_C_virus_infection .
21652515	0	CD8	91,94	FoxP3	9,14	CD8	FoxP3	925	50943	Gene	Gene	CD28-CTL|compound|START_ENTITY activity|nmod|CD28-CTL enhance|dobj|activity +|ccomp|enhance +|nsubj|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
22092408	0	CD8	70,73	FoxP3	78,83	CD8	FoxP3	925	50943	Gene	Gene	+|compound|START_ENTITY +|nmod|cells cells|amod|END_ENTITY	In breast_cancer , a high ratio of tumour-infiltrating intraepithelial CD8 + to FoxP3 + cells is characteristic for the medullary subtype .
22373353	0	CD8	68,71	FoxP3	15,20	CD8	FoxP3	925	50943	Gene	Gene	cells|amod|START_ENTITY cytotoxicity|nmod|cells suppress|dobj|cytotoxicity cells|dep|suppress END_ENTITY|dobj|cells	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress cytotoxicity of CD8 -LRB- + -RRB- effector T cells : implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level .
22871805	0	CD8	69,72	FoxP3	0,5	CD8	FoxP3	925	50943	Gene	Gene	functional|dep|START_ENTITY memory|amod|functional generation|nmod|memory control|dobj|generation control|nsubj|cells cells|nummod|END_ENTITY	FoxP3 regulatory CD4 T cells control the generation of functional CD8 memory .
22879926	0	CD8	62,65	FoxP3	21,26	CD8	FoxP3	925	50943	Gene	Gene	density|compound|START_ENTITY +|nmod|density +|nsubj|impact impact|nmod|END_ENTITY	Prognostic impact of FoxP3 + regulatory T cells in relation to CD8 + T lymphocyte density in human colon_carcinomas .
24980778	0	CD8	8,11	FoxP3	12,17	CD8	FoxP3	925	50943	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Induced CD8 + FoxP3 + Treg Cells in Rheumatoid_Arthritis Are Modulated by p38 Phosphorylation and Monocytes Expressing Membrane Tumor_Necrosis_Factor_a and CD86 .
17720157	0	CD8	50,53	Foxp3	42,47	CD8	Foxp3	925	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|amod|END_ENTITY	Transforming_growth_factor_beta-producing Foxp3 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells induced by iris pigment_epithelial cells display regulatory phenotype and acquire regulatory functions .
17921346	0	CD8	82,85	Foxp3	15,20	CD8	Foxp3	925	50943	Gene	Gene	lymphocytes|compound|START_ENTITY generation|nmod|lymphocytes mediated|nmod|generation mediated|dobj|leads leads|amod|END_ENTITY	IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8 + cytotoxic T lymphocytes .
19022917	0	CD8	18,21	Foxp3	27,32	CD8	Foxp3	925	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal_cancer tissue .
19616200	0	CD8	15,18	Foxp3	79,84	CD8	Foxp3	925	50943	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19620303	0	CD8	49,52	Foxp3	20,25	CD8	Foxp3	925	50943	Gene	Gene	subset|compound|START_ENTITY thymocytes|nmod|subset thymocytes|nsubj|development development|nmod|+ +|amod|END_ENTITY	Rare development of Foxp3 + thymocytes in the CD4 + CD8 + subset .
20042455	0	CD8	32,35	Foxp3	26,31	CD8	Foxp3	925	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	IL-6 positively regulates Foxp3 + CD8 + T cells in vivo .
20142839	0	CD8	61,64	Foxp3	0,5	CD8	Foxp3	925	50943	Gene	Gene	stage|compound|START_ENTITY precedes|dobj|stage precedes|nsubj|induction induction|amod|END_ENTITY	Foxp3 induction in human and murine thymus precedes the CD4 + CD8 + stage but requires early T-cell receptor expression .
20181533	0	CD8	88,91	Foxp3	19,24	CD8	Foxp3	925	50943	Gene	Gene	function|compound|START_ENTITY correlates|nmod|function correlates|nsubj|Enrichment Enrichment|nmod|cells cells|amod|END_ENTITY	Enrichment of CCR6 + Foxp3 + regulatory T cells in the tumor mass correlates with impaired CD8 + T cell function and poor prognosis of breast_cancer .
20221835	0	CD8	63,66	Foxp3	32,37	CD8	Foxp3	925	50943	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|parataxis|associated	Higher intratumoral infiltrated Foxp3 + Treg numbers and Foxp3 + / CD8 + ratio are associated with adverse prognosis in resectable gastric_cancer .
20639494	0	CD8	80,83	Foxp3	0,5	CD8	Foxp3	925	50943	Gene	Gene	response|compound|START_ENTITY modulating|dobj|response limit|advcl|modulating limit|nsubj|cells cells|compound|END_ENTITY	Foxp3 + CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory_syncytial_virus_infection .
21312192	0	CD8	0,3	Foxp3	5,10	CD8	Foxp3	925	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21312192	0	CD8	0,3	Foxp3	84,89	CD8	Foxp3	925	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ share|nsubj|cells share|nmod|cells cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21352252	0	CD8	77,80	Foxp3	26,31	CD8	Foxp3	925	50943	Gene	Gene	cells|compound|START_ENTITY suppress|dobj|cells T|ccomp|suppress T|nsubj|IL-17 IL-17|compound|END_ENTITY	Colorectal_cancer-derived Foxp3 -LRB- + -RRB- IL-17 -LRB- + -RRB- T cells suppress tumour-specific CD8 + T cells .
21469126	0	CD8	42,45	Foxp3	58,63	CD8	Foxp3	925	50943	Gene	Gene	CTLA-4|compound|START_ENTITY CTLA-4|compound|END_ENTITY	Human plasmacytoid dendritic cells induce CD8 LAG-3 Foxp3 CTLA-4 regulatory T cells that suppress allo-reactive memory T cells .
21518973	0	CD8	67,70	Foxp3	9,14	CD8	Foxp3	925	50943	Gene	Gene	lung_inflammation|compound|START_ENTITY dispensable|nmod|lung_inflammation +|ccomp|dispensable +|nsubj|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
22609353	0	CD8	64,67	Foxp3	73,78	CD8	Foxp3	925	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22681667	0	CD8	15,18	Foxp3	20,25	CD8	Foxp3	925	50943	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|protect protect|nsubj|cells cells|amod|END_ENTITY	Donor-specific CD8 + Foxp3 + T cells protect skin allografts and facilitate induction of conventional CD4 + Foxp3 + regulatory T cells .
23858029	0	CD8	14,17	Foxp3	83,88	CD8	Foxp3	925	50943	Gene	Gene	signals|compound|START_ENTITY Inhibition|nmod|signals sufficient|nsubj|Inhibition sufficient|nmod|+ +|compound|END_ENTITY	Inhibition of CD8 + T cell-derived CD40 signals is necessary but not sufficient for Foxp3 + induced regulatory T cell generation in vivo .
25548225	0	CD8	112,115	Foxp3	99,104	CD8	Foxp3	925	50943	Gene	Gene	Promoter|compound|START_ENTITY END_ENTITY|nmod|Promoter	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
25548225	0	CD8	40,43	Foxp3	99,104	CD8	Foxp3	925	50943	Gene	Gene	Binding|compound|START_ENTITY Methylation|nmod|Binding Methylation|nmod|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
17182686	0	CD8	0,3	Gag	60,63	CD8	Gag	925	155030(Tax:11676)	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|epitopes epitopes|nmod|regions regions|compound|END_ENTITY	CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low_steady-state_viremia in human_immunodeficiency_virus_type_1-seropositive patients .
17548613	0	CD8	33,36	Gag	109,112	CD8	Gag	925	155030(Tax:11676)	Gene	Gene	Availability|nmod|START_ENTITY +|nsubj|Availability +|dobj|specific specific|nmod|epitope epitope|compound|END_ENTITY	Availability of a diversely avid CD8 + T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope .
18945768	0	CD8	91,94	Gag	117,120	CD8	Gag	925	155030(Tax:11676)	Gene	Gene	T-cell|compound|START_ENTITY escape|nmod|T-cell consequences|nmod|escape epitope|nsubj|consequences epitope|nmod|protein protein|compound|END_ENTITY	Functional consequences of human immunodeficiency virus escape from an HLA-B * 13-restricted CD8 + T-cell epitope in p1 Gag protein .
21887282	0	CD8	23,26	Gag	110,113	CD8	Gag	925	155030(Tax:11676)	Gene	Gene	response|nummod|START_ENTITY targets|nsubj|response targets|dobj|region region|nmod|Thais Thais|compound|END_ENTITY	A novel immunodominant CD8 + T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais .
17570460	0	CD8	131,134	GrB	6,9	CD8	GrB	925	3002	Gene	Gene	lymphocytes|compound|START_ENTITY associated|nmod|lymphocytes associated|nsubjpass|response response|compound|END_ENTITY	Lower GrB + CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes .
17570460	0	CD8	21,24	GrB	6,9	CD8	GrB	925	3002	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Lower GrB + CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes .
19616200	0	CD8	15,18	GrB	73,76	CD8	GrB	925	3002	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
17825804	0	CD8	55,58	Granzyme_B	0,10	CD8	Granzyme B	925	3002	Gene	Gene	cells|nummod|START_ENTITY distinguishes|dobj|cells distinguishes|nsubj|production production|compound|END_ENTITY	Granzyme_B production distinguishes recently activated CD8 -LRB- + -RRB- memory cells from resting memory cells .
25245659	0	CD8	95,98	Granzyme_B	0,10	CD8	Granzyme B	925	3002	Gene	Gene	cells|compound|START_ENTITY regulated|advcl|cells regulated|nsubjpass|cells cells|amod|END_ENTITY	Granzyme_B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells .
15316240	0	CD8	66,69	Growth_hormone	0,14	CD8	Growth hormone	925	2688	Gene	Gene	trafficking|nmod|START_ENTITY stimulates|dobj|trafficking stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the selective trafficking of thymic CD4 + CD8 - emigrants to peripheral lymphoid organs .
19144272	0	CD8	19,22	HER-2	60,65	CD8	HER-2	925	2064	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	CCL16 enhances the CD8 + and CD4 + T cell reactivity to human HER-2 elicited by dendritic cells loaded with rat ortholog HER-2 .
11086086	0	CD8	114,117	HLA-A	92,97	CD8	HLA-A	925	3105	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dobj|cells	Identification of major epitopes of Mycobacterium_tuberculosis AG85B that are recognized by HLA-A * 0201-restricted CD8 + T cells in HLA-transgenic_mice and humans .
11477559	0	CD8	32,35	HLA-A	60,65	CD8	HLA-A	925	3105	Gene	Gene	Detection|nmod|START_ENTITY T|nsubj|Detection T|xcomp|peptides peptides|dep|specific specific|nmod|END_ENTITY	Detection and quantification of CD8 -LRB- + -RRB- T cells specific for HLA-A * 0201-binding melanoma and viral peptides by the IFN-gamma-ELISPOT assay .
11485622	0	CD8	205,208	HLA-A	0,5	CD8	HLA-A	925	3105	Gene	Gene	type|dep|START_ENTITY generate|dobj|type peptide|xcomp|generate alleles|parataxis|peptide alleles|advmod|END_ENTITY	HLA-A * 26 , HLA-B * 4002 , HLA-B * 4006 , and HLA-B * 4801 alleles predispose to adult_T_cell_leukemia : the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8 -LRB- + -RRB- cytotoxic T lymphocytes .
11535524	0	CD8	75,78	HLA-A	28,33	CD8	HLA-A	925	3105	Gene	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	Efficient identification of HLA-A * 2402-restricted cytomegalovirus-specific CD8 -LRB- + -RRB- T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay .
11730845	0	CD8	80,83	HLA-A	11,16	CD8	HLA-A	925	3105	Gene	Gene	T|compound|START_ENTITY use|nmod|T use|nmod|END_ENTITY	The use of HLA-A * 0201-transfected K562 as standard antigen-presenting_cells for CD8 -LRB- + -RRB- T lymphocytes in IFN-gamma ELISPOT assays .
11751984	0	CD8	26,29	HLA-A	50,55	CD8	HLA-A	925	3105	Gene	Gene	Generation|nmod|START_ENTITY T|nsubj|Generation T|dobj|responses responses|nmod|END_ENTITY	Generation of genome-wide CD8 T cell responses in HLA-A * 0201 transgenic_mice by an HIV-1 ubiquitin expression library immunization vaccine .
12668642	0	CD8	16,19	HLA-A	58,63	CD8	HLA-A	925	3105	Gene	Gene	responses|compound|START_ENTITY responses|nmod|epitopes epitopes|compound|END_ENTITY	Quantitation of CD8 + T cell responses to newly identified HLA-A * 0201-restricted T cell epitopes conserved among vaccinia and variola _ -LRB- smallpox -RRB- _ viruses .
15153496	0	CD8	111,114	HLA-A	160,165	CD8	HLA-A	925	3105	Gene	Gene	epitopes|compound|START_ENTITY identifying|dobj|epitopes sufficient|advcl|identifying recognized|dep|sufficient recognized|nmod|context context|nmod|END_ENTITY	Random screening of proteins for HLA-A * 0201-binding nine-amino_acid_peptides is not sufficient for identifying CD8 T cell epitopes recognized in the context of HLA-A * 0201 .
15153496	0	CD8	111,114	HLA-A	33,38	CD8	HLA-A	925	3105	Gene	Gene	epitopes|compound|START_ENTITY identifying|dobj|epitopes sufficient|advcl|identifying recognized|dep|sufficient recognized|nsubj|screening screening|nmod|proteins proteins|nmod|END_ENTITY	Random screening of proteins for HLA-A * 0201-binding nine-amino_acid_peptides is not sufficient for identifying CD8 T cell epitopes recognized in the context of HLA-A * 0201 .
15802306	0	CD8	0,3	HLA-A	38,43	CD8	HLA-A	925	3105	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|xcomp|present present|dep|specific specific|nmod|END_ENTITY	CD8 + T cells specific for a potential HLA-A * 0201 epitope from Chlamydophila_pneumoniae are present in the PBMCs from infected patients .
16339578	0	CD8	0,3	HLA-A	21,26	CD8	HLA-A	925	3105	Gene	Gene	T|compound|START_ENTITY cell-mediated|nsubj|T cell-mediated|dobj|* *|compound|END_ENTITY	CD8 + T cell-mediated HLA-A * 0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple_sclerosis .
17911594	0	CD8	0,3	HLA-A	90,95	CD8	HLA-A	925	3105	Gene	Gene	T|nsubj|START_ENTITY T|nmod|peptides peptides|nmod|END_ENTITY	CD8 T cell responses to myelin_oligodendrocyte_glycoprotein-derived peptides in humanized HLA-A * 0201-transgenic_mice .
18097044	0	CD8	22,25	HLA-A	0,5	CD8	HLA-A	925	3105	Gene	Gene	epitopes|compound|START_ENTITY identified|nsubj|epitopes glycoprotein_D|dep|identified glycoprotein_D|nsubj|END_ENTITY	HLA-A * 0201-restricted CD8 + cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein_D .
18753217	0	CD8	52,55	HLA-A	18,23	CD8	HLA-A	925	3105	Gene	Gene	T-cell|compound|START_ENTITY epitopes|nsubj|T-cell shared|dep|epitopes shared|nsubj|Identification Identification|nmod|END_ENTITY	Identification of HLA-A * 01 - and HLA-A * 02-restricted CD8 + T-cell epitopes shared among group B enteroviruses .
19698161	0	CD8	94,97	HLA-A	18,23	CD8	HLA-A	925	3105	Gene	Gene	T|compound|START_ENTITY targets|nmod|T lymphocytes|nsubj|targets epitopes|advcl|lymphocytes epitopes|nsubj|Identification Identification|nmod|END_ENTITY	Identification of HLA-A * 2402-restricted HCMV immediate early-1 -LRB- IE-1 -RRB- epitopes as targets for CD8 + HCMV-specific cytotoxic T lymphocytes .
20123035	0	CD8	43,46	HLA-A	21,26	CD8	HLA-A	925	3105	Gene	Gene	epitope|compound|START_ENTITY epitope|amod|END_ENTITY	Identification of an HLA-A * 0201-restricted CD8 -LRB- + -RRB- T-cell epitope encoded within Leptospiral_immunoglobulin-like_protein_A .
20166182	0	CD8	64,67	HLA-A	42,47	CD8	HLA-A	925	3105	Gene	Gene	epitope|dep|START_ENTITY END_ENTITY|dep|epitope	Identification of a dengue virus-specific HLA-A * 0201-restricted CD8 + T cell epitope .
20488208	0	CD8	130,133	HLA-A	110,115	CD8	HLA-A	925	3105	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The resistance mutation R155K in the NS3/4A protease of hepatitis_C_virus also leads the virus to escape from HLA-A * 68-restricted CD8 T cells .
20709007	0	CD8	0,3	HLA-A	24,29	CD8	HLA-A	925	3105	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	CD8 + T cell response in HLA-A * 0201 transgenic_mice is elicited by epitopes from SARS-CoV S protein .
21530544	0	CD8	59,62	HLA-A	37,42	CD8	HLA-A	925	3105	Gene	Gene	0201-restricted|dep|START_ENTITY screening|amod|0201-restricted screening|nmod|END_ENTITY	Knowledge-based virtual screening of HLA-A * 0201-restricted CD8 + T-cell epitope peptides from herpes simplex virus genome .
21745520	0	CD8	74,77	HLA-A	24,29	CD8	HLA-A	925	3105	Gene	Gene	cells|compound|START_ENTITY augmented|nsubjpass|cells S|acl:relcl|augmented restricted|dobj|S restricted|nsubj|responses responses|nmod|END_ENTITY	The immune responses of HLA-A * 0201 restricted SARS-CoV S peptide-specific CD8 T cells are augmented in varying degrees by CpG ODN , PolyI : C and R848 .
22480777	0	CD8	40,43	HLA-A	18,23	CD8	HLA-A	925	3105	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Identification of HLA-A * 0201-restricted CD8 + T-cell epitope C from hepatitis_B virus core protein .
22539795	0	CD8	139,142	HLA-A	7,12	CD8	HLA-A	925	3105	Gene	Gene	epitopes|compound|START_ENTITY source|nmod|epitopes identify|nmod|source nonobese|ccomp|identify nonobese|nmod|* *|amod|END_ENTITY	Beyond HLA-A * 0201 : new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8 + T cell epitopes .
23911395	0	CD8	81,84	HLA-A	26,31	CD8	HLA-A	925	3105	Gene	Gene	epitope|compound|START_ENTITY restricted|dobj|epitope restricted|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a novel HLA-A * 24:02 - restricted adenovirus serotype 11-specific CD8 + T-cell epitope for adoptive immunotherapy .
23997182	0	CD8	40,43	HLA-A	18,23	CD8	HLA-A	925	3105	Gene	Gene	response|compound|START_ENTITY END_ENTITY|xcomp|response	An immunodominant HLA-A * 1101-restricted CD8 + T-cell response targeting hepatitis_B surface antigen in chronic hepatitis_B patients .
24101547	0	CD8	123,126	HLA-A	13,18	CD8	HLA-A	925	3105	Gene	Gene	cells|compound|START_ENTITY recall|dobj|cells herpes|acl:relcl|recall restricted|nmod|herpes restricted|nsubj|END_ENTITY	Asymptomatic HLA-A * 02:01 - restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8 + T cells from seropositive asymptomatic individuals and protect HLA transgenic_mice against ocular_herpes .
25008925	0	CD8	127,130	HLA-A	43,48	CD8	HLA-A	925	3105	Gene	Gene	cells|compound|START_ENTITY virus|nmod|cells END_ENTITY|dobj|virus	Impact of sequence variation in a dominant HLA-A * 02-restricted epitope_in_hepatitis_C virus on priming and cross-reactivity of CD8 + T cells .
27036003	0	CD8	52,55	HLA-A	30,35	CD8	HLA-A	925	3105	Gene	Gene	immunity|compound|START_ENTITY END_ENTITY|dobj|immunity	Molecular basis for universal HLA-A * 0201-restricted CD8 + T-cell immunity against influenza viruses .
27072810	0	CD8	68,71	HLA-A	18,23	CD8	HLA-A	925	3105	Gene	Gene	T|compound|START_ENTITY restricted|dobj|T restricted|nsubj|Identification Identification|nmod|END_ENTITY	Identification of HLA-A * 11:01 - restricted Mycobacterium_tuberculosis CD8 -LRB- + -RRB- T cell epitopes .
2784196	0	CD8	73,76	HLA-A	38,43	CD8	HLA-A	925	3105	Gene	Gene	binding|nmod|START_ENTITY affects|xcomp|binding affects|nsubj|Polymorphism Polymorphism|nmod|domain domain|nmod|molecules molecules|amod|END_ENTITY	Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8 .
17892322	0	CD8	28,31	HLA-B	70,75	CD8	HLA-B	925	3106	Gene	Gene	antigens|nsubj|START_ENTITY antigens|xcomp|restricted restricted|nmod|END_ENTITY	Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B .
17911249	0	CD8	54,57	HLA-B	82,87	CD8	HLA-B	925	3106	Gene	Gene	association|nmod|START_ENTITY T|nsubj|association T|nmod|genotype genotype|amod|END_ENTITY	Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype .
18275350	0	CD8	15,18	HLA-B	51,56	CD8	HLA-B	925	3106	Gene	Gene	epitope|compound|START_ENTITY epitope|acl|presented presented|nmod|END_ENTITY	Targeting of a CD8 T cell env epitope presented by HLA-B * 5802 is associated with markers of HIV_disease_progression and lack of selection pressure .
18945768	0	CD8	91,94	HLA-B	71,76	CD8	HLA-B	925	3106	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Functional consequences of human immunodeficiency virus escape from an HLA-B * 13-restricted CD8 + T-cell epitope in p1 Gag protein .
18945771	0	CD8	12,15	HLA-B	98,103	CD8	HLA-B	925	3106	Gene	Gene	Evidence|nmod|START_ENTITY +|nsubj|Evidence +|dobj|pressure pressure|nmod|nef nef|nmod|END_ENTITY	Evidence of CD8 + T-cell-mediated selective pressure on human_immunodeficiency_virus_type_1 nef in HLA-B * 57 + elite suppressors .
20638093	0	CD8	58,61	HLA-B	30,35	CD8	HLA-B	925	3106	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Immunodominant HIV-1-specific HLA-B - and HLA-C-restricted CD8 + T cells do not differ in polyfunctionality .
22072759	0	CD8	43,46	HLA-B	23,28	CD8	HLA-B	925	3106	Gene	Gene	response|compound|START_ENTITY requires|nsubj|response Escape|dep|requires Escape|nmod|END_ENTITY	Escape from a dominant HLA-B * 15-restricted CD8 + T cell response against hepatitis_C_virus requires compensatory mutations outside the epitope .
22880104	0	CD8	40,43	HLA-B	56,61	CD8	HLA-B	925	3106	Gene	Gene	Cells|compound|START_ENTITY elicitation|nmod|Cells END_ENTITY|nsubj|elicitation	Effective elicitation of human effector CD8 + T Cells in HLA-B * 51:01 transgenic humanized mice after infection with HIV-1 .
23079801	0	CD8	125,128	HLA-B	20,25	CD8	HLA-B	925	3106	Gene	Gene	cells|compound|START_ENTITY number|nmod|cells associated|nmod|number control|parataxis|associated control|nmod|END_ENTITY	Poor HIV control in HLA-B * 27 and B * 57/58 noncontrollers is associated with limited number of polyfunctional Gag p24-specific CD8 + T cells .
23209413	0	CD8	124,127	HLA-B	77,82	CD8	HLA-B	925	3106	Gene	Gene	epitope|compound|START_ENTITY antigen|dep|epitope antigen|dobj|processing processing|nmod|END_ENTITY	Rapid antigen processing and presentation of a protective and immunodominant HLA-B * 27-restricted hepatitis_C virus-specific CD8 + T-cell epitope .
24131719	0	CD8	71,74	HLA-B	5,10	CD8	HLA-B	925	3106	Gene	Gene	response|compound|START_ENTITY contribute|nmod|response contribute|nsubj|levels levels|amod|END_ENTITY	Both HLA-B * 57 and plasma HIV RNA levels contribute to the HIV-specific CD8 + T cell response in HIV controllers .
24330837	0	CD8	0,3	HLA-B	18,23	CD8	HLA-B	925	3106	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	CD8 + T cells from HLA-B * 57 elite suppressors effectively suppress replication of HIV-1 escape mutants .
24349220	0	CD8	6,9	HLA-B	103,108	CD8	HLA-B	925	3106	Gene	Gene	cells|compound|START_ENTITY respond|nsubj|cells respond|nmod|epitopes epitopes|nmod|CFP10 CFP10|acl|restricted restricted|nmod|alleles alleles|amod|END_ENTITY	Human CD8 + T cells from TB_pleurisy respond to four immunodominant epitopes in Mtb CFP10 restricted by HLA-B alleles .
25243920	0	CD8	119,122	HLA-B	91,96	CD8	HLA-B	925	3106	Gene	Gene	restricted|xcomp|START_ENTITY END_ENTITY|ccomp|restricted	Human_herpesvirus_6B immediate-early I protein contains functional HLA-A * 02 , HLA-A * 03 , and HLA-B * 07 class I restricted CD8 -LRB- + -RRB- T-cell epitopes .
26372480	0	CD8	97,100	HLA-B	74,79	CD8	HLA-B	925	3106	Gene	Gene	activation|compound|START_ENTITY eliminates|dep|activation eliminates|dobj|END_ENTITY	Towards depersonalized abacavir therapy : chemical modification eliminates HLA-B * 57:01 - restricted CD8 + T-cell activation .
9710228	0	CD8	191,194	HLA-B	108,113	CD8	HLA-B	925	3106	Gene	Gene	peptide-specific|dep|START_ENTITY recognition|amod|peptide-specific influences|dobj|recognition influences|nsubj|His116 His116|acl|differentiating differentiating|dobj|END_ENTITY	The naturally occurring polymorphism Asp116 -- > His116 , differentiating the ankylosing_spondylitis-associated HLA-B * 2705 from the non-associated HLA-B * 2709 subtype , influences peptide-specific CD8 T cell recognition .
9710228	0	CD8	191,194	HLA-B	143,148	CD8	HLA-B	925	3106	Gene	Gene	peptide-specific|dep|START_ENTITY recognition|amod|peptide-specific influences|dobj|recognition influences|nsubj|His116 His116|acl|differentiating differentiating|dobj|HLA-B HLA-B|nmod|END_ENTITY	The naturally occurring polymorphism Asp116 -- > His116 , differentiating the ankylosing_spondylitis-associated HLA-B * 2705 from the non-associated HLA-B * 2709 subtype , influences peptide-specific CD8 T cell recognition .
10447404	0	CD8	8,11	HLA_class_I_molecule	27,47	CD8	HLA class I molecule	925	3135	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Soluble CD8 stabilizes the HLA_class_I_molecule by promoting beta2M exchange : analysis in real-time .
24922078	0	CD8	58,61	HSP90	10,15	CD8	HSP90	925	3320	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	Defect in HSP90 expression in highly differentiated human CD8 -LRB- + -RRB- T lymphocytes .
22895471	0	CD8	65,68	Her2neu	48,55	CD8	Her2neu	925	2064	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Determining optimal cytotoxic activity of human Her2neu specific CD8 T cells by comparing the Cr51 release assay to the xCELLigence system .
23354485	0	CD8	49,52	IFITM3	133,139	CD8	IFITM3	925	10410	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Enhanced survival of lung tissue-resident memory CD8 T cells during infection with influenza virus due to selective expression of IFITM3 .
10413659	0	CD8	42,45	IFN-gamma	9,18	CD8	IFN-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY vitro|nmod|T cells|amod|vitro production|nmod|cells production|amod|END_ENTITY	Enhanced IFN-gamma production in vitro by CD8 + T cells in hemophiliacs with AIDS as demonstrated on the single-cell level .
10551378	0	CD8	55,58	IFN-gamma	23,32	CD8	IFN-gamma	925	3458	Gene	Gene	lymphocytes|nummod|START_ENTITY circulating|dobj|lymphocytes intracellular|advcl|circulating intracellular|dobj|levels levels|amod|END_ENTITY	Elevated intracellular IFN-gamma levels in circulating CD8 + lymphocytes in patients with fulminant_hepatitis .
10636490	0	CD8	27,30	IFN-gamma	16,25	CD8	IFN-gamma	925	3458	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	HTLV-I specific IFN-gamma + CD8 + lymphocytes correlate with the proviral load in peripheral blood of infected individuals .
10799875	0	CD8	41,44	IFN-gamma	137,146	CD8	IFN-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY lymphocyte|nsubj|T lymphocyte|nmod|END_ENTITY	Monophosphoryl_lipid_A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes_simplex_virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production .
10861058	0	CD8	42,45	IFN-gamma	29,38	CD8	IFN-gamma	925	3458	Gene	Gene	rejection|compound|START_ENTITY contribution|nmod|rejection contribution|nmod|END_ENTITY	An essential contribution by IFN-gamma to CD8 + T cell-mediated rejection of pancreatic islet allografts .
10925295	0	CD8	56,59	IFN-gamma	28,37	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of intracellular IFN-gamma in HSV-1-specific CD8 + T cells identifies distinct responding subpopulations during the primary response to infection .
10964541	0	CD8	80,83	IFN-gamma	16,25	CD8	IFN-gamma	925	3458	Gene	Gene	correlates|nmod|START_ENTITY increase|nmod|correlates increase|nmod|production production|amod|END_ENTITY	The increase of IFN-gamma production through aging correlates with the expanded CD8 -LRB- + high -RRB- CD28 -LRB- - -RRB- CD57 -LRB- + -RRB- subpopulation .
11012976	0	CD8	22,25	IFN-gamma	118,127	CD8	IFN-gamma	925	3458	Gene	Gene	responses|compound|START_ENTITY identification|dep|responses identification|nmod|ELISPOT ELISPOT|compound|END_ENTITY	HLA-A * 0201 restricted CD8 + T-lymphocyte responses to malaria : identification of new Plasmodium_falciparum epitopes by IFN-gamma ELISPOT .
11167992	0	CD8	143,146	IFN-gamma	118,127	CD8	IFN-gamma	925	3458	Gene	Gene	lymphocytes|compound|START_ENTITY interferon-gamma|nmod|lymphocytes interferon-gamma|appos|END_ENTITY	Patients with inflammatory_bowel_disease -LRB- IBD -RRB- reveal increased induction capacity of intracellular interferon-gamma -LRB- IFN-gamma -RRB- in peripheral CD8 + lymphocytes co-cultured with intestinal epithelial cells .
11390521	0	CD8	43,46	IFN-gamma	8,17	CD8	IFN-gamma	925	3458	Gene	Gene	lymphocytes|compound|START_ENTITY circulating|dobj|lymphocytes secretion|advcl|circulating END_ENTITY|acl|secretion	Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes : implications of a novel approach for T cell monitoring in infectious and malignant_diseases .
11730845	0	CD8	80,83	IFN-gamma	104,113	CD8	IFN-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY use|nmod|T lymphocytes|nsubj|use lymphocytes|nmod|assays assays|amod|END_ENTITY	The use of HLA-A * 0201-transfected K562 as standard antigen-presenting_cells for CD8 -LRB- + -RRB- T lymphocytes in IFN-gamma ELISPOT assays .
11825525	0	CD8	59,62	IFN-gamma	20,29	CD8	IFN-gamma	925	3458	Gene	Gene	assay|nmod|START_ENTITY assay|amod|END_ENTITY	-LSB- Application of the IFN-gamma ELISPOT assay for monitoring CD8 -LRB- + -RRB- T cell response to specific antigen from hepatocellular_carcinoma patients -RSB- .
14579273	0	CD8	65,68	IFN-gamma	0,9	CD8	IFN-gamma	925	3458	Gene	Gene	engagement|nmod|START_ENTITY NK|nmod|engagement NK|nsubj|production production|amod|END_ENTITY	IFN-gamma production in human NK cells through the engagement of CD8 by soluble or surface HLA class I molecules .
14698862	0	CD8	120,123	IFN-gamma	96,105	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Cyclophosphamide modulates CD4 + T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8 + T cells in secondary progressive multiple_sclerosis .
15210805	0	CD8	39,42	IFN-gamma	61,70	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY initiate|nsubj|cells initiate|dobj|synthesis synthesis|amod|END_ENTITY	The rapidity with which virus-specific CD8 + T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance .
15384046	0	CD8	95,98	IFN-gamma	66,75	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|amod|END_ENTITY	Reduced antigen concentration and costimulatory blockade increase IFN-gamma secretion in naive CD8 + T cells .
15629089	0	CD8	40,43	IFN-gamma	14,23	CD8	IFN-gamma	925	3458	Gene	Gene	cell|compound|START_ENTITY level|nmod|cell level|amod|END_ENTITY	-LSB- Detection of IFN-gamma level in single CD8 + T cell -RSB- .
15814691	0	CD8	83,86	IFN-gamma	31,40	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8 + effector T cells .
15922715	0	CD8	56,59	IFN-gamma	79,88	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY promotes|dobj|cells promotes|xcomp|produce produce|dobj|END_ENTITY	A human Langerhans cell-like cell line , ELD-1 , promotes CD8 T cells to produce IFN-gamma through CD70-dependent alternative pathway .
16246570	0	CD8	51,54	IFN-gamma	31,40	CD8	IFN-gamma	925	3458	Gene	Gene	T-cells|compound|START_ENTITY T-cells|amod|END_ENTITY	Association between peripheral IFN-gamma producing CD8 + T-cells and disability score in relapsing-remitting multiple_sclerosis .
16352669	0	CD8	52,55	IFN-gamma	64,73	CD8	IFN-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY T|dep|expression expression|amod|END_ENTITY	Effect of medical castration on CD4 + CD25 + T cells , CD8 + T cell IFN-gamma expression , and NK cells : a physiological role for testosterone and/or its metabolites .
16441508	0	CD8	38,41	IFN-gamma	14,23	CD8	IFN-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|amod|END_ENTITY	Evaluation of IFN-gamma production by CD8 T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma_cruzi .
16818762	0	CD8	63,66	IFN-gamma	38,47	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY loci|nmod|cells loci|amod|END_ENTITY	Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells .
16920922	0	CD8	50,53	IFN-gamma	61,70	CD8	IFN-gamma	925	3458	Gene	Gene	generate|dobj|START_ENTITY Overcoming|advcl|generate Overcoming|nsubj|responses responses|amod|END_ENTITY	Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced host .
17222752	0	CD8	62,65	IFN-gamma	22,31	CD8	IFN-gamma	925	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY role|nmod|cells role|nmod|END_ENTITY	An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation .
17277117	0	CD8	40,43	IFN-gamma	5,14	CD8	IFN-gamma	925	3458	Gene	Gene	lymphocytes|compound|START_ENTITY production|nmod|lymphocytes production|amod|END_ENTITY	High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 -LRB- CTLA-4 -RRB- .
17404259	0	CD8	80,83	IFN-gamma	51,60	CD8	IFN-gamma	925	3458	Gene	Gene	memory|compound|START_ENTITY secretion|nmod|memory secretion|amod|END_ENTITY	Profound enhancement of the IL-12 / IL-18 pathway of IFN-gamma secretion in human CD8 + memory T cell subsets via IL-15 .
17675470	0	CD8	68,71	IFN-gamma	26,35	CD8	IFN-gamma	925	3458	Gene	Gene	homeostasis|compound|START_ENTITY regulation|nmod|homeostasis Role|nmod|regulation Role|nmod|effects effects|nmod|END_ENTITY	Role of direct effects of IFN-gamma on T cells in the regulation of CD8 T cell homeostasis .
19535638	0	CD8	90,93	IFN-gamma	0,9	CD8	IFN-gamma	925	3458	Gene	Gene	responses|nummod|START_ENTITY generation|nmod|responses suppress|dobj|generation cells|ccomp|suppress promotes|xcomp|cells promotes|nsubj|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19957810	0	CD8	33,36	IFN-gamma	120,129	CD8	IFN-gamma	925	3458	Gene	Gene	-LSB-|nmod|START_ENTITY -RSB-|advcl|-LSB- -RSB-|nsubj|levels levels|amod|END_ENTITY	-LSB- The relationship between CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T cells in the peripheral blood of patients with pancreatic_carcinoma and IL-4 , IFN-gamma levels -RSB- .
20156102	0	CD8	41,44	IFN-gamma	48,57	CD8	IFN-gamma	925	3458	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells inhibit CD8 -LRB- + -RRB- IFN-gamma production during acute and chronic FIV_infection utilizing a membrane TGF-beta-dependent mechanism .
20562261	0	CD8	62,65	IFN-gamma	0,9	CD8	IFN-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|nsubj|END_ENTITY	IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response .
20889558	0	CD8	95,98	IFN-gamma	68,77	CD8	IFN-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY mechanisms|dep|T mechanisms|dep|role role|nmod|END_ENTITY	Host defense mechanisms in secondary syphilitic lesions : a role for IFN-gamma - / IL-17-producing CD8 + T cells ?
7569779	0	CD8	63,66	IFN-gamma	106,115	CD8	IFN-gamma	925	3458	Gene	Gene	depletion|compound|START_ENTITY autoimmune_myasthenia_gravis|nmod|depletion Suppression|nmod|autoimmune_myasthenia_gravis associated|nsubjpass|Suppression associated|nmod|END_ENTITY	Suppression of experimental autoimmune_myasthenia_gravis after CD8 depletion is associated with decreased IFN-gamma and IL-4 .
8148319	0	CD8	145,148	IFN-gamma	125,134	CD8	IFN-gamma	925	3458	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells END_ENTITY|acl|producing	Quantitation of human influenza virus-specific cytotoxic T lymphocytes : correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8 + T cells .
8964081	0	CD8	74,77	IFN-gamma	48,57	CD8	IFN-gamma	925	3458	Gene	Gene	clone|compound|START_ENTITY production|nmod|clone production|amod|END_ENTITY	Difference in signal transduction for IL-10 and IFN-gamma production in a CD8 + T cell clone .
9207753	0	CD8	36,39	IFN-gamma	111,120	CD8	IFN-gamma	925	3458	Gene	Gene	cells|nummod|START_ENTITY cells|dep|IL-6 IL-6|nmod|END_ENTITY	Differential development of CD4 and CD8 cytotoxic T cells -LRB- CTL -RRB- in PBMC across the leprosy spectrum ; IL-6 with IFN-gamma or IL-2 generate CTL in multibacillary patients .
9472663	0	CD8	18,21	IFN-gamma	169,178	CD8	IFN-gamma	925	3458	Gene	Gene	lymphocytes|nummod|START_ENTITY defect|nmod|lymphocytes defect|dep|abnormalities abnormalities|nmod|production production|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9472663	0	CD8	228,231	IFN-gamma	169,178	CD8	IFN-gamma	925	3458	Gene	Gene	+|compound|START_ENTITY defect|dep|+ defect|dep|abnormalities abnormalities|nmod|production production|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9820134	0	CD8	73,76	IFN-gamma	14,23	CD8	IFN-gamma	925	3458	Gene	Gene	recruitment|compound|START_ENTITY precedes|dobj|recruitment precedes|nsubj|expression expression|amod|END_ENTITY	Intracellular IFN-gamma expression in natural killer cells precedes lung CD8 + T cell recruitment during respiratory_syncytial_virus_infection .
20967288	0	CD8	0,3	IFN-y	28,33	CD8	IFN-y	925	3458	Gene	Gene	+|nsubj|START_ENTITY +|nmod|source source|nmod|production production|amod|END_ENTITY	CD8 + T cells as a source of IFN-y production in human cutaneous_leishmaniasis .
22235780	0	CD8	9,12	IFN-y	21,26	CD8	IFN-y	925	3458	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Effector CD8 + T cell IFN-y production and cytotoxicity are enhanced by mild hyperthermia .
22297636	0	CD8	96,99	IFN-y	73,78	CD8	IFN-y	925	3458	Gene	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	A mouse model of vitiligo with focused epidermal_depigmentation requires IFN-y for autoreactive CD8 T-cell accumulation in the skin .
23223131	0	CD8	0,3	IFN-y	107,112	CD8	IFN-y	925	3458	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|source source|nmod|END_ENTITY	CD8 -LRB- + -RRB- T cells in the lesional skin of atopic_dermatitis and psoriasis patients are an important source of IFN-y , IL-13 , IL-17 , and IL-22 .
23251217	0	CD8	49,52	IFN-y	12,17	CD8	IFN-y	925	3458	Gene	Gene	capacity|nmod|START_ENTITY capacity|compound|END_ENTITY	The average IFN-y secreting capacity of specific CD8 -LRB- + -RRB- T cells is compromised while increasing copies of a single T cell epitope encoded by DNA vaccine .
23280240	0	CD8	28,31	IFN-y	83,88	CD8	IFN-y	925	3458	Gene	Gene	+|compound|START_ENTITY Maintenance|nmod|+ T|nsubj|Maintenance T|nmod|levels levels|amod|END_ENTITY	Maintenance of CMV-specific CD8 + T cell responses and the relationship of IL-27 to IFN-y levels with aging .
23684306	0	CD8	7,10	IFN-y	36,41	CD8	IFN-y	925	3458	Gene	Gene	cells|compound|START_ENTITY outsource|nsubj|cells outsource|dobj|production production|amod|END_ENTITY	Memory CD8 T cells can outsource IFN-y production but not cytolytic killing for antiviral protection .
25015828	0	CD8	23,26	IFN-y	62,67	CD8	IFN-y	925	3458	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|pulse pulse|nmod|END_ENTITY	Antigen-specific naive CD8 + T cells produce a single pulse of IFN-y in vivo within hours of infection , but without antiviral effect .
25275588	0	CD8	89,92	IFN-y	128,133	CD8	IFN-y	925	3458	Gene	Gene	CD44|compound|START_ENTITY activating|dobj|CD44 atrophy|advcl|activating cells|amod|atrophy induces|dobj|cells induces|advcl|upregulating upregulating|dobj|END_ENTITY	Severe influenza_A -LRB- H1N1 -RRB- pdm09_infection induces thymic atrophy through activating innate CD8 -LRB- + -RRB- CD44 -LRB- hi -RRB- T cells by upregulating IFN-y .
25476730	0	CD8	85,88	IFN-y	62,67	CD8	IFN-y	925	3458	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	mTOR signaling promotes a robust and continuous production of IFN-y by human memory CD8 -LRB- + -RRB- T cells and their proliferation .
25480562	0	CD8	16,19	IFN-y	0,5	CD8	IFN-y	925	3458	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	IFN-y Regulates CD8 + Memory T Cell Differentiation and Survival in Response to Weak , but Not Strong , TCR Signals .
26309093	0	CD8	90,93	IFN-y	20,25	CD8	IFN-y	925	3458	Gene	Gene	Cells|compound|START_ENTITY IL-10|nmod|Cells Potentiation|nmod|IL-10 Potentiation|nmod|END_ENTITY	The Potentiation of IFN-y and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells .
10940925	0	CD8	28,31	IL-10	88,93	CD8	IL-10	925	3586	Gene	Gene	T|nsubj|START_ENTITY T|nmod|phenotype phenotype|nmod|END_ENTITY	Glucocorticoids drive human CD8 -LRB- + -RRB- T cell differentiation towards a phenotype with high IL-10 and reduced IL-4 , IL-5 and IL-13 production .
11985521	0	CD8	146,149	IL-10	87,92	CD8	IL-10	925	3586	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ role|nmod|cells effects|dep|role effects|dep|cells cells|nmod|production production|nmod|END_ENTITY	The effects of CD40 - _ and_interleukin -LRB- IL-4 -RRB- - activated CD23 + cells on the production of IL-10 by mononuclear cells in Graves ' _ disease : the role of CD8 + cells .
16951047	0	CD8	82,85	IL-10	10,15	CD8	IL-10	925	3586	Gene	Gene	cells|compound|START_ENTITY reduces|nmod|cells reduces|nsubj|overexpression overexpression|compound|END_ENTITY	Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8 + cells and prolongs cardiac allograft survival .
17544800	0	CD8	16,19	IL-10	0,5	CD8	IL-10	925	3586	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells END_ENTITY|acl|producing	IL-10 producing CD8 + T cells in human infection with Leishmania_guyanensis .
19535638	0	CD8	90,93	IL-10	33,38	CD8	IL-10	925	3586	Gene	Gene	responses|nummod|START_ENTITY generation|nmod|responses suppress|dobj|generation cells|ccomp|suppress cells|nsubj|generation generation|nmod|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
20089329	0	CD8	0,3	IL-10	24,29	CD8	IL-10	925	3586	Gene	Gene	cells|nummod|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	CD8 + T cells expressing IL-10 are associated with a favourable prognosis in lung_cancer .
20127276	0	CD8	113,116	IL-10	82,87	CD8	IL-10	925	3586	Gene	Gene	T|compound|START_ENTITY explain|nmod|T explain|dobj|modulation modulation|nmod|synthesis synthesis|compound|END_ENTITY	sHLA-I Contamination , a novel mechanism to explain ex vivo/in vitro modulation of IL-10 synthesis and release in CD8 -LRB- + -RRB- T lymphocytes and in neutrophils following intravenous immunoglobulin infusion .
22581824	0	CD8	52,55	IL-10	0,5	CD8	IL-10	925	3586	Gene	Gene	cells|amod|START_ENTITY activates|dobj|cells activates|nsubj|END_ENTITY	IL-10 directly activates and expands tumor-resident CD8 -LRB- + -RRB- T cells without de novo infiltration from secondary lymphoid organs .
23091017	0	CD8	43,46	IL-10	73,78	CD8	IL-10	925	3586	Gene	Gene	cells|compound|START_ENTITY responsiveness|nmod|cells loss|nmod|responsiveness abrogates|nsubj|loss abrogates|dobj|expression expression|compound|END_ENTITY	Persistent loss of IL-27 responsiveness in CD8 + memory T cells abrogates IL-10 expression in a recall response .
23264920	0	CD8	77,80	IL-10	37,42	CD8	IL-10	925	3586	Gene	Gene	T|nsubj|START_ENTITY activates|ccomp|T activates|nsubj|END_ENTITY	Autochthonous T cells to the rescue : IL-10 directly activates tumor-resident CD8 -LRB- + -RRB- T cells .
23666891	0	CD8	108,111	IL-10	10,15	CD8	IL-10	925	3586	Gene	Gene	T|compound|START_ENTITY inducer|nmod|T IL-10|nmod|inducer cytotoxicity|amod|IL-10 role|nmod|cytotoxicity immunity|dep|role induces|dobj|immunity induces|nsubj|END_ENTITY	Pegylated IL-10 induces cancer immunity : the surprising role of IL-10 as a potent inducer of IFN-y-mediated CD8 -LRB- + -RRB- T cell cytotoxicity .
23666891	0	CD8	108,111	IL-10	64,69	CD8	IL-10	925	3586	Gene	Gene	T|compound|START_ENTITY inducer|nmod|T END_ENTITY|nmod|inducer	Pegylated IL-10 induces cancer immunity : the surprising role of IL-10 as a potent inducer of IFN-y-mediated CD8 -LRB- + -RRB- T cell cytotoxicity .
25316133	0	CD8	37,40	IL-10	130,135	CD8	IL-10	925	3586	Gene	Gene	FoxP3|compound|START_ENTITY levels|nmod|FoxP3 changes|nmod|levels changes|dep|role role|nmod|END_ENTITY	Allergy-related changes in levels of CD8 + CD25 + FoxP3 -LRB- bright -RRB- Treg cells and FoxP3 mRNA expression in peripheral blood : the role of IL-10 or TGF-beta .
25446896	0	CD8	24,27	IL-10	11,16	CD8	IL-10	925	3586	Gene	Gene	responses|compound|START_ENTITY blocks|dobj|responses blocks|nsubj|END_ENTITY	Macrophage IL-10 blocks CD8 + T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells .
25751015	0	CD8	46,49	IL-10	10,15	CD8	IL-10	925	3586	Gene	Gene	T|nsubj|START_ENTITY enhance|ccomp|T enhance|nsubj|blockade blockade|compound|END_ENTITY	Transient IL-10 receptor blockade can enhance CD8 -LRB- + -RRB- T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen .
26147684	0	CD8	118,121	IL-10	14,19	CD8	IL-10	925	3586	Gene	Gene	maturation|nmod|START_ENTITY promotes|dobj|maturation promotes|nmod|Production Production|nmod|END_ENTITY	Production of IL-10 by CD4 -LRB- + -RRB- regulatory T cells during the resolution of infection promotes the maturation of memory CD8 -LRB- + -RRB- T cells .
26309093	0	CD8	90,93	IL-10	75,80	CD8	IL-10	925	3586	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	The Potentiation of IFN-y and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells .
7917114	0	CD8	43,46	IL-10	27,32	CD8	IL-10	925	3586	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells END_ENTITY|acl|producing	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
8104996	0	CD8	37,40	IL-10	6,11	CD8	IL-10	925	3586	Gene	Gene	lymphocytes|compound|START_ENTITY chemoattractant|nmod|lymphocytes chemoattractant|nsubj|END_ENTITY	Human IL-10 is a chemoattractant for CD8 + T lymphocytes and an inhibitor of IL-8-induced CD4 + T lymphocyte migration .
9531274	0	CD8	53,56	IL-10	38,43	CD8	IL-10	925	3586	Gene	Gene	cells|compound|START_ENTITY effects|nmod|cells effects|nmod|END_ENTITY	Inhibitory and stimulatory effects of IL-10 on human CD8 + T cells .
16488622	0	CD8	56,59	IL-13	36,41	CD8	IL-13	925	3596	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|compound|END_ENTITY	Cross-linking of 4-1BB up-regulates IL-13 expression in CD8 -LRB- + -RRB- T lymphocytes .
19582753	0	CD8	80,83	IL-13	48,53	CD8	IL-13	925	3596	Gene	Gene	CTL|compound|START_ENTITY modulate|dobj|CTL modulate|nsubj|END_ENTITY	Immunisation route-dependent expression of IL-4 / IL-13 can modulate HIV-specific CD8 -LRB- + -RRB- CTL avidity .
25493691	0	CD8	34,37	IL-13	67,72	CD8	IL-13	925	3596	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Regulated|nsubjpass|Expression END_ENTITY|dep|Regulated	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
7495748	0	CD8	62,65	IL-13	27,32	CD8	IL-13	925	3596	Gene	Gene	+|compound|START_ENTITY production|nmod|+ production|compound|END_ENTITY	Differential regulation of IL-13 and IL-4 production by human CD8 + and CD4 + Th0 , Th1 and Th2 T cell clones and EBV-transformed B cells .
10820241	0	CD8	124,127	IL-15	66,71	CD8	IL-15	925	3600	Gene	Gene	CD44high|compound|START_ENTITY proliferation|nmod|CD44high allows|dobj|proliferation allows|nsubj|signals signals|compound|END_ENTITY	Constitutive expression of a chimeric receptor that delivers IL-2 / IL-15 signals allows antigen-independent proliferation of CD8 + CD44high but not other T cells .
11358712	0	CD8	25,28	IL-15	59,64	CD8	IL-15	925	3600	Gene	Gene	analysis|nmod|START_ENTITY T-cell|nsubj|analysis T-cell|dobj|expression expression|amod|END_ENTITY	Longitudinal analysis of CD8 -LRB- + -RRB- T-cell phenotype and IL-7 , IL-15 and IL-16 mRNA expression in different tissues during primary simian_immunodeficiency_virus_infection .
12472672	0	CD8	70,73	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	cultures|compound|START_ENTITY induces|nmod|cultures induces|nsubj|END_ENTITY	IL-15 induces unspecific effector functions in human peptide-specific CD8 + T-cell cultures .
12805064	0	CD8	79,82	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells induces|dobj|expansion induces|nsubj|END_ENTITY	IL-15 induces antigen-independent expansion and differentiation of human naive CD8 + T cells in vitro .
14684414	0	CD8	35,38	IL-15	90,95	CD8	IL-15	925	3600	Gene	Gene	+|compound|START_ENTITY responses|nummod|+ responses|dep|role role|nmod|END_ENTITY	Mature dendritic cells can enhance CD8 + cell noncytotoxic anti-HIV responses : the role of IL-15 .
14762166	0	CD8	64,67	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells enhances|dobj|activity enhances|nsubj|END_ENTITY	IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 + T cells .
15972637	0	CD8	93,96	IL-15	33,38	CD8	IL-15	925	3600	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells plasmid|nmod|function plasmid|nsubj|Coimmunization Coimmunization|nmod|END_ENTITY	Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help .
16040381	0	CD8	17,20	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	IL-15 : targeting CD8 + T cells for immunotherapy .
16937447	0	CD8	60,63	IL-15	20,25	CD8	IL-15	925	3600	Gene	Gene	cells|compound|START_ENTITY longevity|nmod|cells enhances|dobj|longevity enhances|nsubj|Coimmunization Coimmunization|nmod|plasmid plasmid|compound|END_ENTITY	Coimmunization with IL-15 plasmid enhances the longevity of CD8 T cells induced by DNA encoding hepatitis_B virus core antigen .
17353346	0	CD8	68,71	IL-15	129,134	CD8	IL-15	925	3600	Gene	Gene	T-cell|compound|START_ENTITY growth|nmod|T-cell clone|nsubj|growth clone|nmod|transduction transduction|nmod|gene gene|compound|END_ENTITY	Cytokine-independent growth and clonal expansion of a primary human CD8 + T-cell clone following retroviral transduction with the IL-15 gene .
17404259	0	CD8	80,83	IL-15	111,116	CD8	IL-15	925	3600	Gene	Gene	memory|compound|START_ENTITY secretion|nmod|memory pathway|nmod|secretion T|nsubj|pathway T|dobj|subsets subsets|nmod|END_ENTITY	Profound enhancement of the IL-12 / IL-18 pathway of IFN-gamma secretion in human CD8 + memory T cell subsets via IL-15 .
17635814	0	CD8	92,95	IL-15	36,41	CD8	IL-15	925	3600	Gene	Gene	cells|compound|START_ENTITY predominance|nmod|cells associated|nmod|predominance associated|nsubjpass|END_ENTITY	Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8 + T cells at heart lesions of human chronic Chagas_disease_cardiomyopathy .
17880761	0	CD8	19,22	IL-15	3,8	CD8	IL-15	925	3600	Gene	Gene	response|compound|START_ENTITY response|amod|dependent dependent|amod|END_ENTITY	An IL-15 dependent CD8 T cell response to selected HIV_epitopes is related to viral control in early-treated HIV-infected subjects .
18362335	0	CD8	37,40	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	longevity|compound|START_ENTITY help|nmod|longevity help|nsubj|END_ENTITY	IL-15 as a mediator of CD4 + help for CD8 + T cell longevity and avoidance of TRAIL-mediated apoptosis .
18812469	0	CD8	29,32	IL-15	56,61	CD8	IL-15	925	3600	Gene	Gene	homeostasis|compound|START_ENTITY homeostasis|nmod|transpresentation transpresentation|compound|END_ENTITY	Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation .
19380870	0	CD8	84,87	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	competition|nmod|START_ENTITY underlies|dobj|competition underlies|nsubj|END_ENTITY	IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and -LCB- gamma -RCB- -LCB- delta -RCB- T cells in vivo .
20212069	0	CD8	72,75	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	survival|compound|START_ENTITY promotes|dobj|survival promotes|nsubj|trans-presentation trans-presentation|compound|END_ENTITY	IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus_infection .
20926794	0	CD8	43,46	IL-15	34,39	CD8	IL-15	925	3600	Gene	Gene	functions|compound|START_ENTITY Contribution|nmod|functions Contribution|nmod|END_ENTITY	Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple_sclerosis .
20926799	0	CD8	57,60	IL-15	41,46	CD8	IL-15	925	3600	Gene	Gene	proliferation|compound|START_ENTITY requirement|nmod|proliferation requirement|nmod|END_ENTITY	No requirement of trans presentations of IL-15 for human CD8 T cell proliferation .
20956026	0	CD8	14,17	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	cells|compound|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	IL-15 induces CD8 + T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion .
21098221	0	CD8	46,49	IL-15	11,16	CD8	IL-15	925	3600	Gene	Gene	T|compound|START_ENTITY migration|nmod|T END_ENTITY|nmod|migration	A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza_infection .
21474552	0	CD8	91,94	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	responses|nummod|START_ENTITY induction|nmod|responses deficiency|nmod|induction overcomes|dobj|deficiency overcomes|nsubj|vivo vivo|compound|END_ENTITY	IL-15 ex vivo overcomes CD4 + T cell deficiency for the induction of human antigen-specific CD8 + T cell responses .
21911607	0	CD8	30,33	IL-15	15,20	CD8	IL-15	925	3600	Gene	Gene	cell|compound|START_ENTITY enhances|dobj|cell enhances|nsubj|END_ENTITY	B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple_sclerosis patients .
22539288	0	CD8	53,56	IL-15	0,5	CD8	IL-15	925	16168(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|nsubj|END_ENTITY	IL-15 inhibits IL-7Ra expression by memory-phenotype CD8 T cells in the bone marrow .
23355737	0	CD8	58,61	IL-15	43,48	CD8	IL-15	925	3600	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	CD8a + dendritic cell trans presentation of IL-15 to naive CD8 + T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function .
23711708	0	CD8	104,107	IL-15	41,46	CD8	IL-15	925	3600	Gene	Gene	responses|compound|START_ENTITY induce|dobj|responses induce|nsubj|cells cells|nmod|END_ENTITY	Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8 + CD28 + T lymphocyte responses .
24842641	0	CD8	42,45	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	proliferation|compound|START_ENTITY induces|dobj|proliferation induces|nsubj|END_ENTITY	IL-15 induces alloreactive CD28 -LRB- - -RRB- memory CD8 T cell proliferation and CTLA4-Ig resistant memory CD8 T cell activation .
26034206	0	CD8	36,39	IL-15	85,90	CD8	IL-15	925	3600	Gene	Gene	T|compound|START_ENTITY lymphocytes|nsubj|T lymphocytes|nmod|END_ENTITY	CD4 + CD28null T lymphocytes resemble CD8 + CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients .
26141233	0	CD8	56,59	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	responses|compound|START_ENTITY induces|dobj|responses induces|nsubj|END_ENTITY	IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast_cancer .
26857736	0	CD8	75,78	IL-15	0,5	CD8	IL-15	925	3600	Gene	Gene	cells|nummod|START_ENTITY differentiated|dobj|cells boosts|ccomp|differentiated boosts|nsubj|END_ENTITY	IL-15 boosts the function and migration of human terminally differentiated CD8 + T cells by inducing a unique gene signature .
9620680	0	CD8	53,56	IL-15	77,82	CD8	IL-15	925	3600	Gene	Gene	stimulation|nmod|START_ENTITY +|nsubj|stimulation +|nmod|END_ENTITY	Potent and selective stimulation of memory-phenotype CD8 + T cells in vivo by IL-15 .
12671073	0	CD8	27,30	IL-15R_alpha	0,12	CD8	IL-15R alpha	925	3601	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	IL-15R_alpha expression on CD8 + T cells is dispensable for T cell memory .
11204252	0	CD8	30,33	IL-16	71,76	CD8	IL-16	925	3603	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ role|nmod|cells role|amod|END_ENTITY	A possible pathogenic role of CD8 + T cells and their derived cytokine , IL-16 , in SLE .
11240037	0	CD8	135,138	IL-16	78,83	CD8	IL-16	925	3603	Gene	Gene	T-lymphocytes|compound|START_ENTITY granulocytes|appos|T-lymphocytes infiltrating|dobj|granulocytes confined|advcl|infiltrating expression|acl|confined expression|appos|END_ENTITY	Human focal cerebral_infarctions induce differential lesional interleukin-16 -LRB- IL-16 -RRB- expression confined to infiltrating granulocytes , CD8 + T-lymphocytes and activated microglia/macrophages .
12191564	0	CD8	28,31	IL-16	104,109	CD4	IL-16	920	3603	Gene	Gene	T|compound|START_ENTITY T|dep|reference reference|nmod|END_ENTITY	Relationship between CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T cell ratio and T cell activation in multiple_myeloma : reference to IL-16 .
21036918	0	CD8	37,40	IL-16	28,33	CD8	IL-16	925	3603	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Effects of tobacco smoke on IL-16 in CD8 + cells from human airways and blood : a key role for oxygen free radicals ?
8598478	0	CD8	81,84	IL-16	13,18	CD8	IL-16	925	3603	Gene	Gene	cells|compound|START_ENTITY Secretion|nmod|cells Secretion|nmod|END_ENTITY	Secretion of IL-16 -LRB- lymphocyte_chemoattractant_factor -RRB- from serotonin-stimulated CD8 + T cells in vitro .
19201830	0	CD8	71,74	IL-17	94,99	CD8	IL-17	925	3605	Gene	Gene	cells|compound|START_ENTITY characterization|nmod|cells characterization|acl|producing producing|dobj|END_ENTITY	Cutting edge : Phenotypic characterization and differentiation of human CD8 + T cells producing IL-17 .
19616200	0	CD8	15,18	IL-17	102,107	CD8	IL-17	925	3605	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|Foxp3 Foxp3|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19953909	0	CD8	44,47	IL-17	49,54	CD8	IL-17	925	3605	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Possible mechanisms of peripheral elevated CD8 + IL-17 + T cells in rheumatoid_arthritis -RSB- .
21352252	0	CD8	77,80	IL-17	35,40	CD8	IL-17	925	3605	Gene	Gene	cells|compound|START_ENTITY suppress|dobj|cells T|ccomp|suppress T|nsubj|END_ENTITY	Colorectal_cancer-derived Foxp3 -LRB- + -RRB- IL-17 -LRB- + -RRB- T cells suppress tumour-specific CD8 + T cells .
21477350	0	CD8	0,3	IL-17	29,34	CD8	IL-17	925	3605	Gene	Gene	cells|nummod|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	CD8 positive T cells express IL-17 in patients with chronic_obstructive_pulmonary_disease .
22230497	0	CD8	75,78	IL-17	129,134	CD8	IL-17	925	3605	Gene	Gene	stem|nmod|START_ENTITY -LSB-|dep|stem -LSB-|nsubj|activation activation|appos|cellcycle cellcycle|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effect of human placenta-derived mesenchymal stem cells on cord blood CD8 -LRB- + -RRB- ; T cells activation , cellcycle and secretion of IL-17 -RSB- .
23517930	0	CD8	30,33	IL-17	23,28	CD8	IL-17	925	3605	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fraction of IL-10 + and IL-17 + CD8 T cells is increased in MS patients in remission and during a relapse , but is not influenced by immune modulators .
24375061	0	CD8	25,28	IL-17	0,5	CD8	IL-17	925	3605	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells END_ENTITY|acl|producing	IL-17 and IL-4 producing CD8 + T cells in tumor draining lymph nodes of breast_cancer patients : positive association with tumor progression .
9878122	0	CD8	50,53	IL-17	14,19	CD8	IL-17	925	3605	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of IL-17 , IFN-gamma and IL-10 in human CD8 -LRB- + -RRB- T cells by cyclic_AMP-dependent signal transduction pathway .
21124836	0	CD8	49,52	IL-17A	22,28	CD8	IL-17A	925	3605	Gene	Gene	cells|compound|START_ENTITY producing|dobj|cells Overrepresentation|acl|producing Overrepresentation|nmod|END_ENTITY	Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis .
25381766	0	CD8	65,68	IL-17A	43,49	CD8	IL-17A	925	3605	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Psoriasis and the MAITing game : a role for IL-17A + invariant TCR CD8 + T cells in psoriasis ?
25493691	0	CD8	34,37	IL-17A	0,6	CD8	IL-17A	925	3605	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
10224467	0	CD8	20,23	IL-2	56,60	CD8	IL-2	925	3558	Gene	Gene	expression|compound|START_ENTITY expression|nmod|chain chain|compound|END_ENTITY	IL-4 inhibits human CD8 T cell expression of the common IL-2 receptor gamma chain .
10820241	0	CD8	124,127	IL-2	61,65	CD8	IL-2	925	3558	Gene	Gene	CD44high|compound|START_ENTITY proliferation|nmod|CD44high allows|dobj|proliferation expression|parataxis|allows expression|acl:relcl|delivers delivers|xcomp|END_ENTITY	Constitutive expression of a chimeric receptor that delivers IL-2 / IL-15 signals allows antigen-independent proliferation of CD8 + CD44high but not other T cells .
10882412	0	CD8	27,30	IL-2	56,60	CD8	IL-2	925	3558	Gene	Gene	expression|nmod|START_ENTITY Loss|nmod|expression IFN|nsubj|Loss IFN|parataxis|induced induced|nmod|chain chain|compound|END_ENTITY	Loss of CD28 expression on CD8 -LRB- + -RRB- T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN , and increases susceptibility to activation-induced apoptosis .
10975812	0	CD8	59,62	IL-2	17,21	CD8	IL-2	925	3558	Gene	Gene	memory|compound|START_ENTITY generation|nmod|memory END_ENTITY|nmod|generation	The dual role of IL-2 in the generation and maintenance of CD8 + memory T cells .
11477452	0	CD8	138,141	IL-2	114,118	CD8	IL-2	925	3558	Gene	Gene	immunity|compound|START_ENTITY induction|nmod|immunity Immunotherapy|dep|induction Immunotherapy|nmod|tumors tumors|nmod|mice mice|nmod|injection injection|nmod|vector vector|acl|harboring harboring|dobj|cDNA cDNA|compound|END_ENTITY	Immunotherapy of established tumors in mice by intratumoral injection of an adenovirus vector harboring the human IL-2 cDNA : induction of CD8 -LRB- + -RRB- T-cell immunity and NK activity .
11591778	0	CD8	137,140	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	promotes|dobj|START_ENTITY promotes|dep|END_ENTITY	IL-2 during in vitro priming promotes subsequent engraftment and successful adoptive tumor immunotherapy by persistent memory phenotypic CD8 -LRB- + -RRB- T cells .
12023352	0	CD8	69,72	IL-2	19,23	CD8	IL-2	925	3558	Gene	Gene	responses|compound|START_ENTITY extralymphoid|dobj|responses extralymphoid|nsubj|role role|nmod|END_ENTITY	Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses .
12165496	0	CD8	59,62	IL-2	20,24	CD8	IL-2	925	3558	Gene	Gene	growth|compound|START_ENTITY effects|dep|growth effects|nmod|END_ENTITY	Opposing effects of IL-2 in tumor immunotherapy : promoting CD8 T cell growth and inducing apoptosis .
12963692	0	CD8	40,43	IL-2	99,103	CD8	IL-2	925	3558	Gene	Gene	effector|compound|START_ENTITY effector|acl:relcl|reconstitutes reconstitutes|dobj|production production|compound|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
14634080	0	CD8	43,46	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	cycling|compound|START_ENTITY initiation|nmod|cycling required|nmod|initiation required|nsubjpass|END_ENTITY	IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion .
15024180	0	CD8	26,29	IL-2	10,14	CD8	IL-2	925	3558	Gene	Gene	+|compound|START_ENTITY therapy|nmod|+ therapy|compound|END_ENTITY	Effect of IL-2 therapy on CD8 + cell noncytotoxic anti-HIV response during primary HIV-1_infection .
15223897	0	CD8	35,38	IL-2	47,51	CD8	IL-2	925	3558	Gene	Gene	inhibition|nmod|START_ENTITY +|nsubj|inhibition +|dobj|production production|compound|END_ENTITY	Defective inhibition of peripheral CD8 + T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection .
1531763	0	CD8	44,47	IL-2	82,86	CD8	IL-2	925	3558	Gene	Gene	START_ENTITY|dep|precursors precursors|nmod|pathway pathway|compound|END_ENTITY	IL-7 induces proliferation of CD3 - / low CD4 - CD8 - human thymocyte precursors by an IL-2 independent pathway .
15384078	0	CD8	80,83	IL-2	55,59	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Frontline : An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo .
16456009	0	CD8	54,57	IL-2	100,104	CD8	IL-2	925	3558	Gene	Gene	responses|compound|START_ENTITY enhances|dobj|responses enhances|nmod|inhibition inhibition|compound|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16751372	0	CD8	46,49	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells required|nmod|activation required|nsubjpass|END_ENTITY	IL-2 is required for the activation of memory CD8 + T cells via antigen cross-presentation .
16751420	0	CD8	50,53	IL-2	14,18	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|Modulation Modulation|nmod|END_ENTITY	Modulation by IL-2 of CD70 and CD27 expression on CD8 + T cells : importance for the therapeutic effectiveness of cell transfer immunotherapy .
1676547	0	CD8	25,28	IL-2	76,80	CD8	IL-2	925	3558	Gene	Gene	lymphocytes|compound|START_ENTITY Activation|nmod|lymphocytes Activation|dep|evidence evidence|nmod|transcription transcription|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
16806475	0	CD8	39,42	IL-2	13,17	CD8	IL-2	925	3558	Gene	Gene	blasts|compound|START_ENTITY deprivation|nmod|blasts deprivation|compound|END_ENTITY	Apoptosis by IL-2 deprivation in human CD8 + T cell blasts predominates over death receptor ligation , requires Bim expression and is associated with Mcl-1 loss .
16859558	0	CD8	78,81	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells correlates|nmod|differentiation correlates|nsubj|production production|compound|END_ENTITY	IL-2 production correlates with effector cell differentiation in HIV-specific CD8 + T cells .
17414320	0	CD8	98,101	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells induction|nmod|expression END_ENTITY|dep|induction	IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells .
17664293	0	CD8	6,9	IL-2	73,77	CD8	IL-2	925	3558	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|differentiate differentiate|nmod|treatment treatment|compound|END_ENTITY	Naive CD8 + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo .
17664293	0	CD8	6,9	IL-2	83,87	CD8	IL-2	925	3558	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|differentiate differentiate|nmod|treatment treatment|compound|END_ENTITY	Naive CD8 + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo .
17664294	0	CD8	54,57	IL-2	75,79	CD8	IL-2	925	3558	Gene	Gene	naive|dep|START_ENTITY cells|amod|naive proliferation|nmod|cells form|nmod|proliferation driven|nsubj|form driven|nmod|END_ENTITY	An intense form of homeostatic proliferation of naive CD8 + cells driven by IL-2 .
18178855	0	CD8	18,21	IL-2	97,101	CD8	IL-2	925	3558	Gene	Gene	cell|nummod|START_ENTITY Control|nmod|cell differentiation|nsubj|Control differentiation|nmod|END_ENTITY	Control of memory CD8 + T cell differentiation by CD80/CD86-CD 28 costimulation and restoration by IL-2 during the recall response .
18273057	0	CD8	78,81	IL-2	8,12	CD8	IL-2	925	3558	Gene	Gene	responses|compound|START_ENTITY enhancing|dobj|responses secreted|advcl|enhancing secreted|nsubj|Role Role|nmod|END_ENTITY	Role of IL-2 secreted by PADRE-specific CD4 + T cells in enhancing E7-specific CD8 + T-cell immune responses .
18276844	0	CD8	59,62	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	cells|nummod|START_ENTITY opposing|nmod|cells confer|xcomp|opposing confer|nsubj|END_ENTITY	IL-2 and IL-21 confer opposing differentiation programs to CD8 + T cells for adoptive immunotherapy .
19011158	0	CD8	66,69	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	+|compound|START_ENTITY regulate|dobj|+ regulate|nsubj|cytokines cytokines|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
19801515	0	CD8	37,40	IL-2	86,90	CD8	IL-2	925	3558	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|acl|driven driven|nmod|complexes complexes|nmod|antibody antibody|amod|END_ENTITY	In vivo expansion of activated naive CD8 + T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy .
19841187	0	CD8	18,21	IL-2	115,119	CD8	IL-2	925	3558	Gene	Gene	cells|nummod|START_ENTITY have|nsubj|cells have|dobj|signature signature|acl|characterized characterized|nmod|production production|compound|END_ENTITY	Human late memory CD8 + T cells have a distinct cytokine signature characterized by CC chemokine production without IL-2 production .
19901991	0	CD8	71,74	IL-2	20,24	CD8	IL-2	925	3558	Gene	Gene	responses|compound|START_ENTITY advances|dep|responses signals|nmod|advances signals|nsubj|END_ENTITY	CD4 + T cell-derived IL-2 signals during early priming advances primary CD8 + T cell responses .
20483725	0	CD8	73,76	IL-2	19,23	CD8	IL-2	925	3558	Gene	Gene	effector|nummod|START_ENTITY differentiation|nmod|effector roles|nmod|differentiation roles|nmod|END_ENTITY	Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8 + effector and memory T cells .
21430221	0	CD8	93,96	IL-2	24,28	CD8	IL-2	925	3558	Gene	Gene	cells|nummod|START_ENTITY responsiveness|nmod|cells regulates|dobj|responsiveness regulates|nsubj|sensitivity sensitivity|nmod|signaling signaling|compound|END_ENTITY	Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8 -LRB- + -RRB- T cells in a melanoma model .
21482735	0	CD8	78,81	IL-2	24,28	CD8	IL-2	925	3558	Gene	Gene	therapy|nmod|START_ENTITY +|nsubj|therapy outcome|parataxis|+ outcome|nmod|END_ENTITY	Differential outcome of IL-2 / anti-IL-2 complex therapy on effector and memory CD8 + T cells following vaccination with an adenoviral vector encoding EBV epitopes .
21502514	0	CD8	37,40	IL-2	88,92	CD8	IL-2	925	3558	Gene	Gene	differentiation|compound|START_ENTITY differentiation|nmod|homeostasis homeostasis|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasis .
21718737	0	CD8	75,78	IL-2	69,73	CD8	IL-2	925	3558	Gene	Gene	background|compound|START_ENTITY background|compound|END_ENTITY	Immunogenicity assay validation for an HIV vaccine trial : high IFNy + / IL-2 + CD8 + T cells background in healthy Thais .
21804558	0	CD8	65,68	IL-2	10,14	CD8	IL-2	925	3558	Gene	Gene	cells|amod|START_ENTITY expansion|nmod|cells required|nmod|expansion required|nsubjpass|END_ENTITY	Autocrine IL-2 is required for secondary population expansion of CD8 -LRB- + -RRB- memory T cells .
21849683	0	CD8	39,42	IL-2	74,78	CD8	IL-2	925	3558	Gene	Gene	size|compound|START_ENTITY size|nmod|restriction restriction|compound|END_ENTITY	Regulatory_T cells selectively control CD8 + T cell effector pool size via IL-2 restriction .
24166977	0	CD8	25,28	IL-2	51,55	CD8	IL-2	925	3558	Gene	Gene	cell|compound|START_ENTITY features|nmod|cell activation|nsubj|features activation|nmod|END_ENTITY	Unique features of naive CD8 + T cell activation by IL-2 .
24367005	0	CD8	62,65	IL-2	103,107	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY division|nmod|cells prolong|dobj|division prolong|advcl|maintaining maintaining|dobj|END_ENTITY	IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo .
25015830	0	CD8	54,57	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	differentiation|compound|START_ENTITY signal|nmod|differentiation key|nmod|signal key|nsubj|induction induction|compound|END_ENTITY	IL-2 induction of Blimp-1 is a key in vivo signal for CD8 + short-lived effector T cell differentiation .
25548225	0	CD8	112,115	IL-2	124,128	CD8	IL-2	925	3558	Gene	Gene	Promoter|compound|START_ENTITY Promoter|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
25548225	0	CD8	40,43	IL-2	124,128	CD8	IL-2	925	3558	Gene	Gene	Binding|compound|START_ENTITY Methylation|nmod|Binding Methylation|nmod|Foxp3 Foxp3|nmod|Promoter Promoter|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
2572284	0	CD8	170,173	IL-2	216,220	CD8	IL-2	925	3558	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|presence presence|nmod|END_ENTITY	T-cell ontogeny after autologous bone marrow transplantation : failure to synthesize interleukin-2 -LRB- IL-2 -RRB- and lack of CD2 - and CD3-mediated proliferation by both CD4 - and CD8 + cells even in the presence of exogeneous IL-2 .
25946103	0	CD8	0,3	IL-2	118,122	CD8	IL-2	925	3558	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Fate Fate|nmod|END_ENTITY	CD8 + T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2 .
25946103	0	CD8	0,3	IL-2	118,122	CD8	IL-2	925	3558	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Fate Fate|nmod|END_ENTITY	CD8 + T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2 .
25962156	0	CD8	71,74	IL-2	108,112	CD8	IL-2	925	3558	Gene	Gene	T|compound|START_ENTITY Primary|nmod|T Cells|nsubj|Primary Cells|nmod|Signaling Signaling|compound|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
25962156	0	CD8	71,74	IL-2	113,117	CD8	IL-2	925	3558	Gene	Gene	T|compound|START_ENTITY Primary|nmod|T Cells|nsubj|Primary Cells|nmod|Signaling Signaling|compound|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
26947179	0	CD8	37,40	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY consumption|nmod|cells consumption|compound|END_ENTITY	IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic_lymphohistiocytosis .
7622198	0	CD8	59,62	IL-2	90,94	CD8	IL-2	925	3558	Gene	Gene	+|nummod|START_ENTITY cytotoxic|nmod:npmod|+ cell|amod|cytotoxic functions|nmod|cell Modulation|nmod|functions clone|nsubj|Modulation clone|nmod|END_ENTITY	Modulation of the functions of dengue virus-specific human CD8 + cytotoxic T cell clone by IL-2 , IL-7 and IFN_gamma .
7908892	0	CD8	0,3	IL-2	95,99	CD8	IL-2	925	3558	Gene	Gene	subsets|nummod|START_ENTITY differ|nsubj|subsets differ|nmod|capacity capacity|acl|produce produce|dobj|END_ENTITY	CD8 + T-cell subsets defined by expression of CD45 isoforms differ in their capacity to produce IL-2 , IFN-gamma and TNF-beta .
7989743	0	CD8	27,30	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	cells|compound|START_ENTITY growth|nmod|cells support|dobj|growth support|nsubj|END_ENTITY	IL-2 can support growth of CD8 + T cells but not CD4 + T cells of human IL-2_receptor_beta-chain transgenic_mice .
9190908	0	CD8	57,60	IL-2	0,4	CD8	IL-2	925	3558	Gene	Gene	+|compound|START_ENTITY induces|nmod|+ induces|nsubj|END_ENTITY	IL-2 induces Fas_ligand / Fas -LRB- CD95L/CD95 -RRB- cytotoxicity in CD8 + and CD4 + T lymphocyte clones .
9634197	0	CD8	111,114	IL-2	118,122	CD8	IL-2	925	3558	Gene	Gene	START_ENTITY|nmod|antibody antibody|amod|END_ENTITY	The regulation of phenotype and function of human liver CD3 + / CD56 + lymphocytes , and cells that also co-express CD8 by IL-2 , IL-12 and anti-CD3 monoclonal antibody .
9880014	0	CD8	62,65	IL-2	92,96	CD8	IL-2	925	3558	Gene	Gene	+|compound|START_ENTITY leukocytes|nsubj|+ leukocytes|nmod|gonadotrophin gonadotrophin|amod|END_ENTITY	In vitro reactivation of latent equid_herpesvirus-1 from CD5 + / CD8 + leukocytes indirectly by IL-2 or chorionic gonadotrophin .
15630141	0	CD8	41,44	IL-21	11,16	CD8	IL-21	925	59067	Gene	Gene	expansion|compound|START_ENTITY Synergy|nmod|expansion Synergy|nmod|END_ENTITY	Synergy of IL-21 and IL-15 in regulating CD8 + T cell expansion and function .
16002671	0	CD8	62,65	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells sustains|dobj|expression sustains|nsubj|END_ENTITY	IL-21 sustains CD28 expression on IL-15-activated human naive CD8 + T cells .
16081794	0	CD8	80,83	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	response|compound|START_ENTITY frequency|nmod|response influences|dobj|frequency influences|nsubj|END_ENTITY	IL-21 influences the frequency , phenotype , and affinity of the antigen-specific CD8 T cell response .
17548600	0	CD8	40,43	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells promotes|dobj|differentiation promotes|nsubj|END_ENTITY	IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype .
17921346	0	CD8	82,85	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	lymphocytes|compound|START_ENTITY generation|nmod|lymphocytes mediated|nmod|generation mediated|nsubj|END_ENTITY	IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8 + cytotoxic T lymphocytes .
19687290	0	CD8	27,30	IL-21	43,48	CD8	IL-21	925	59067	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	Induction of granulysin in CD8 + T cells by IL-21 and IL-15 is suppressed by human_immunodeficiency_virus-1 .
19797296	0	CD8	86,89	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhances|dobj|proliferation enhances|nsubj|END_ENTITY	IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28 + CD8 memory T cells throughout the adult age span .
20844201	0	CD8	28,31	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	quality|nummod|START_ENTITY influences|dobj|quality influences|nsubj|deficiency deficiency|compound|END_ENTITY	IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral_infection .
21064084	0	CD8	71,74	IL-21	87,92	CD8	IL-21	925	59067	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells Enhancement|nmod|expression Enhancement|nmod|END_ENTITY	Enhancement of proliferation and downregulation of TRAIL expression on CD8 + T cells by IL-21 .
21257966	0	CD8	42,45	IL-21	10,15	CD8	IL-21	925	59067	Gene	Gene	survival|compound|START_ENTITY critical|nmod|survival critical|nsubj|signaling signaling|compound|END_ENTITY	Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral_infection .
21258423	0	CD8	79,82	IL-21	8,13	CD8	IL-21	925	59067	Gene	Gene	T-cells|compound|START_ENTITY absence|nmod|T-cells attenuates|nmod|absence attenuates|nsubj|Lack Lack|nmod|signal signal|compound|END_ENTITY	Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells .
22238455	0	CD8	102,105	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	T|compound|START_ENTITY manner|nmod|T activation|nmod|manner cells|compound|activation supplement|dobj|cells supplement|nsubj|END_ENTITY	IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8 -LRB- + -RRB- T cells .
22430249	0	CD8	36,39	IL-21	19,24	CD8	IL-21	925	59067	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	IL-27 induction of IL-21 from human CD8 + T cells induces granzyme_B in an autocrine manner .
23479229	0	CD8	15,18	IL-21	0,5	CD8	IL-21	925	59067	Gene	Gene	activity|compound|START_ENTITY promotes|dobj|activity promotes|nsubj|END_ENTITY	IL-21 promotes CD8 + CTL activity via the transcription factor T-bet .
26826252	0	CD8	121,124	IL-21	29,34	CD8	IL-21	925	59067	Gene	Gene	Subsets|compound|START_ENTITY Subsets|amod|END_ENTITY	A Context-Dependent Role for IL-21 in Modulating the Differentiation , Distribution , and Abundance of Effector and Memory CD8 T Cell Subsets .
23483882	0	CD8	125,128	IL-2_receptor_alpha	84,103	CD8	IL-2 receptor alpha	925	3559	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2_receptor_alpha in mature , activated CD8 T cells .
10224467	0	CD8	20,23	IL-4	0,4	CD8	IL-4	925	3565	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits human CD8 T cell expression of the common IL-2 receptor gamma chain .
10329842	0	CD8	58,61	IL-4	14,18	CD8	IL-4	925	3565	Gene	Gene	cells|compound|START_ENTITY ligand|nmod|cells ligand|nsubj|Production Production|nmod|END_ENTITY	Production of IL-4 and expression of CD40 ligand by human CD8 T cells .
10725381	0	CD8	30,33	IL-4	63,67	CD8	IL-4	925	3565	Gene	Gene	induction|nmod|START_ENTITY +|nsubj|induction +|nmod|exposure exposure|compound|END_ENTITY	Potent induction of long-term CD8 + T cell memory by short-term IL-4 exposure during T cell receptor stimulation .
11914057	0	CD8	60,63	IL-4	35,39	CD8	IL-4	925	3565	Gene	Gene	T|compound|START_ENTITY production|nmod|T production|compound|END_ENTITY	Decreased IFN - _ gamma and increased IL-4 production by human CD8 -LRB- + -RRB- T cells in response to Mycobacterium_tuberculosis in tuberculosis patients .
11985521	0	CD8	146,149	IL-4	38,42	CD8	IL-4	925	3565	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ role|nmod|cells effects|dep|role effects|dep|and_interleukin and_interleukin|appos|END_ENTITY	The effects of CD40 - _ and_interleukin -LRB- IL-4 -RRB- - activated CD23 + cells on the production of IL-10 by mononuclear cells in Graves ' _ disease : the role of CD8 + cells .
12220104	0	CD8	30,33	IL-4	122,126	CD8	IL-4	925	3565	Gene	Gene	CD4|dep|START_ENTITY Characterization|nmod|CD4 T|nsubj|Characterization T|dobj|cells cells|dep|production production|nmod|END_ENTITY	Characterization of CD3 + CD4 - CD8 - -LRB- double negative -RRB- T cells in patients with systemic_lupus_erythematosus : production of IL-4 .
16001979	0	CD8	62,65	IL-4	0,4	CD8	IL-4	925	3565	Gene	Gene	cells|compound|START_ENTITY cytokine|nmod|cells cytokine|nsubj|increases increases|compound|END_ENTITY	IL-4 increases type 2 , but not type 1 , cytokine production in CD8 + T cells from mild atopic_asthmatics .
16914507	0	CD8	74,77	IL-4	112,116	CD8	IL-4	925	3565	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhanced|dobj|proliferation enhanced|nmod|manner manner|amod|dependent dependent|nmod|END_ENTITY	CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8 + T cells in a manner dependent on IL-4 .
17084909	0	CD8	34,37	IL-4	60,64	CD8	IL-4	925	3565	Gene	Gene	increased|nsubj|START_ENTITY increased|ccomp|reduced reduced|nsubjpass|production production|compound|END_ENTITY	Glatiramer_acetate-specific human CD8 -LRB- + -RRB- T cells : increased IL-4 production in multiple_sclerosis is reduced by glatiramer_acetate treatment .
17200144	0	CD8	64,67	IL-4	0,4	CD8	IL-4	925	3565	Gene	Gene	cells|compound|START_ENTITY cascade|nmod|cells signaling|dobj|cascade intracellular|acl|signaling induces|dobj|intracellular induces|nsubj|END_ENTITY	IL-4 induces a wide-spectrum intracellular signaling cascade in CD8 + T cells .
18054415	0	CD8	105,108	IL-4	97,101	CD8	IL-4	925	3565	Gene	Gene	cells|compound|START_ENTITY reduces|nmod|cells reduces|dobj|expression expression|nmod|END_ENTITY	Allergen immunotherapy in intermittent_allergic_rhinitis reduces the intracellular expression of IL-4 by CD8 + T cells .
18390584	0	CD8	16,19	IL-4	10,14	CD8	IL-4	925	3565	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|END_ENTITY	Increased IL-4 + CD8 + T cells in peripheral blood and autoreactive CD8 + T cell lines of patients with inflammatory_arthritis .
1911543	0	CD8	24,27	IL-4	86,90	CD8	IL-4	925	3565	Gene	Gene	analysis|nmod|START_ENTITY expressed|nsubj|analysis expressed|dobj|clones clones|acl|cultured cultured|nmod|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
1911543	0	CD8	53,56	IL-4	86,90	CD8	IL-4	925	3565	Gene	Gene	T|compound|START_ENTITY expressed|nmod|T expressed|dobj|clones clones|acl|cultured cultured|nmod|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
19582753	0	CD8	80,83	IL-4	43,47	CD8	IL-4	925	3565	Gene	Gene	CTL|compound|START_ENTITY modulate|dobj|CTL expression|parataxis|modulate expression|nmod|END_ENTITY	Immunisation route-dependent expression of IL-4 / IL-13 can modulate HIV-specific CD8 -LRB- + -RRB- CTL avidity .
2105169	0	CD8	26,29	IL-4	51,55	CD4	IL-4	920	3565	Gene	Gene	cells|compound|START_ENTITY analysis|nmod|cells cloned|nsubj|analysis cloned|nmod|END_ENTITY	Frequency analysis of CD4 + CD8 + T cells cloned with IL-4 .
25493691	0	CD8	34,37	IL-4	62,66	CD8	IL-4	925	3565	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Regulated|nsubjpass|Expression Regulated|nmod|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
7917114	0	CD8	43,46	IL-4	15,19	CD8	IL-4	925	3565	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells IL-10|acl|producing IL-10|appos|END_ENTITY	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
8906216	0	CD8	26,29	IL-4	0,4	CD8	IL-4	925	3565	Gene	Gene	cells|nummod|START_ENTITY naive|dobj|cells naive|nsubj|differentiates differentiates|compound|END_ENTITY	IL-4 differentiates naive CD8 + T cells to a `` Th2-like '' phenotype : a link between viral_infections and bronchial_asthma .
9074413	0	CD8	156,159	IL-4	126,130	CD8	IL-4	925	3565	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Analysis of blood T-cell cytokine expression in B-chronic_lymphocytic_leukaemia : evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells .
7917114	0	CD8	43,46	IL-5	21,25	CD8	IL-5	925	3567	Gene	Gene	cells|nummod|START_ENTITY producing|dobj|cells IL-10|acl|producing IL-10|appos|END_ENTITY	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
22539288	0	CD8	53,56	IL-7Ra	15,21	CD8	IL-7Ra	925	16197(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|expression expression|compound|END_ENTITY	IL-15 inhibits IL-7Ra expression by memory-phenotype CD8 T cells in the bone marrow .
23207282	0	CD8	46,49	IL-7Ra	19,25	CD8	IL-7Ra	925	3575	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	IL-7 downregulates IL-7Ra expression in human CD8 T cells by two independent mechanisms .
16860834	0	CD8	13,16	IL-7Ralpha	47,57	CD8	IL-7Ralpha	925	16197(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|levels levels|nmod|END_ENTITY	HIV-specific CD8 T cells express low levels of IL-7Ralpha : implications for HIV-specific T cell memory .
18647857	0	CD8	15,18	IL4	11,14	CD8	IL4	925	3565	Gene	Gene	cells|nummod|START_ENTITY +|dobj|cells +|nsubj|END_ENTITY	Regulatory IL4 + CD8 + T cells in patients with ankylosing_spondylitis and healthy controls .
12853576	0	CD8	77,80	ILT2	49,53	CD8	ILT2	925	10859	Gene	Gene	compete|nmod|START_ENTITY compete|nsubj|Ig-like_transcript_2 Ig-like_transcript_2|appos|END_ENTITY	Human inhibitory receptors Ig-like_transcript_2 -LRB- ILT2 -RRB- and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G .
14592815	0	CD8	18,21	ILT2	99,103	CD8	ILT2	925	10859	Gene	Gene	+|nummod|START_ENTITY express|nsubj|+ express|dobj|ligand ligand|appos|END_ENTITY	Primary cutaneous CD8 + and CD56 + T-cell_lymphomas express HLA-G and killer-cell inhibitory ligand , ILT2 .
15100307	0	CD8	70,73	ILT2	62,66	CD8	ILT2	925	10859	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Specific recognition of the viral protein UL18 by CD85j/LIR -1 / ILT2 on CD8 + T cells mediates the non-MHC-restricted lysis of human_cytomegalovirus-infected cells .
21213105	0	CD8	59,62	ILT2	22,26	CD8	ILT2	925	10859	Gene	Gene	T|compound|START_ENTITY inhibitor|nmod|T receptor|dep|inhibitor receptor|compound|END_ENTITY	High affinity soluble ILT2 receptor : a potent inhibitor of CD8 -LRB- + -RRB- T cell activation .
25973438	0	CD8	53,56	Interferon-Gamma	22,38	CD8	Interferon-Gamma	925	3458	Gene	Gene	Cells|compound|START_ENTITY Control|nmod|Cells Control|nmod|Expression Expression|compound|END_ENTITY	Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells .
10444028	0	CD8	56,59	Interferon-gamma	0,16	CD8	Interferon-gamma	925	3458	Gene	Gene	lymphocytes|compound|START_ENTITY reduces|dobj|lymphocytes reduces|nsubj|preferentially preferentially|amod|END_ENTITY	Interferon-gamma preferentially reduces memory/effector CD8 T lymphocytes in healthy subjects .
11703361	0	CD8	47,50	Interferon-gamma	0,16	CD8	Interferon-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY secretion|nmod|T secretion|amod|END_ENTITY	Interferon-gamma secretion of peripheral blood CD8 + T lymphocytes in patients with bronchial_asthma : in vitro stimulus determines cytokine production .
12536237	0	CD8	67,70	Interferon-gamma	0,16	CD8	Interferon-gamma	925	3458	Gene	Gene	lymphocytes|compound|START_ENTITY impaired|nmod|lymphocytes impaired|nsubjpass|secretion secretion|amod|END_ENTITY	Interferon-gamma secretion and perforin expression are impaired in CD8 + T lymphocytes from patients with undifferentiated_carcinoma of nasopharyngeal type .
15958073	0	CD8	32,35	Interferon-gamma	0,16	CD8	Interferon-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY produced|nmod|cells produced|nsubjpass|END_ENTITY	Interferon-gamma is produced by CD8 T cells in response to HLA-A24-restricted hepatitis_C_virus epitopes after sustained virus loss .
25721262	0	CD8	96,99	Interferon-gamma	0,16	CD8	Interferon-gamma	925	3458	Gene	Gene	Lymphocytes|compound|START_ENTITY Role|nmod|Lymphocytes Melanogenesis|dep|Role Melanogenesis|amod|END_ENTITY	Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes : A Pivotal Role of CD8 + Cytotoxic T Lymphocytes in Vitiligo .
11568001	0	CD8	53,56	Interleukin-10	0,14	CD8	Interleukin-10	925	3586	Gene	Gene	T-cell|compound|START_ENTITY maintenance|nmod|T-cell promotes|dobj|maintenance promotes|nsubj|END_ENTITY	Interleukin-10 promotes the maintenance of antitumor CD8 -LRB- + -RRB- T-cell effector function in situ .
12508773	0	CD8	64,67	Interleukin-10	0,14	CD8	Interleukin-10	925	3586	Gene	Gene	cells|compound|START_ENTITY contribution|nmod|cells expression|parataxis|contribution expression|amod|END_ENTITY	Interleukin-10 expression : is there a neglected contribution of CD8 + T cells in rheumatoid_arthritis joints ?
16287061	0	CD8	62,65	Interleukin-10	0,14	CD8	Interleukin-10	925	3586	Gene	Gene	infiltration|compound|START_ENTITY correlates|nmod|infiltration correlates|nsubj|expression expression|amod|END_ENTITY	Interleukin-10 expression significantly correlates with minor CD8 + T-cell infiltration and high microvessel density in patients with gastric_cancer .
8624379	0	CD8	116,119	Interleukin-10	0,14	CD8	Interleukin-10	925	3586	Gene	Gene	+|compound|START_ENTITY proliferation|nmod|+ influence|dobj|proliferation influence|nsubj|END_ENTITY	Interleukin-10 , interleukin-12 , and tumor_necrosis_factor-alpha differentially influence the proliferation of human CD8 + and CD4 + T-cell clones .
24331389	0	CD8	27,30	Interleukin-18	0,14	CD8	Interleukin-18	925	3606	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-18 expression , CD8 -LRB- + -RRB- T cells , and eosinophils in lungs of nonsmokers with fatal asthma .
15577620	0	CD8	31,34	Interleukin-2	0,13	CD8	Interleukin-2	925	3558	Gene	Gene	responses|nummod|START_ENTITY restores|dobj|responses restores|nsubj|therapy therapy|amod|END_ENTITY	Interleukin-2 therapy restores CD8 cell non-cytotoxic anti-HIV responses in primary_infection subjects receiving HAART .
19296053	0	CD8	17,20	Interleukin-2	0,13	CD8	Interleukin-2	925	3558	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Interleukin-2 in CD8 + T cells correlates with Banff score during organ rejection in liver transplant recipients .
21621553	0	CD8	40,43	Interleukin-2	0,13	CD8	Interleukin-2	925	3558	Gene	Gene	cells|compound|START_ENTITY rescues|dobj|cells rescues|nsubj|END_ENTITY	Interleukin-2 rescues helpless effector CD8 + T cells by diminishing the susceptibility to TRAIL mediated death .
26744522	0	CD8	96,99	Interleukin-21	68,82	CD8	Interleukin-21	925	59067	Gene	Gene	Cells|compound|START_ENTITY Signaling|nmod|Cells Signaling|compound|END_ENTITY	Improved Treatment of Breast_Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8 + T Cells .
11175852	0	CD8	103,106	Interleukin-4	0,13	CD8	Interleukin-4	925	3565	Gene	Gene	responses|compound|START_ENTITY counter-regulate|dobj|responses acts|xcomp|counter-regulate acts|nsubj|END_ENTITY	Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8 + T-cell responses .
15958076	0	CD8	97,100	Interleukin-4	0,13	CD8	Interleukin-4	925	3565	Gene	Gene	cells|compound|START_ENTITY homing|nmod|cells skin|acl|homing down-regulation|nmod|skin down-regulation|amod|END_ENTITY	Interleukin-4 induced down-regulation of skin homing receptor expression by human viral-specific CD8 T cells may contribute to atopic risk of cutaneous_infection .
17073944	0	CD8	29,32	Interleukin-4	0,13	CD8	Interleukin-4	925	3565	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Interleukin-4 promotes human CD8 T cell expression of CCR7 .
3262830	0	CD8	23,26	Interleukin-4	0,13	CD8	Interleukin-4	925	3565	Gene	Gene	induction|nummod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Interleukin-4 mediates CD8 induction on human CD4 + T-cell clones .
26965634	0	CD8	70,73	Interleukin-7	0,13	CD8	Interleukin-7	925	3574	Gene	Gene	stage|compound|START_ENTITY development|nmod|stage promotes|dobj|development promotes|nsubj|END_ENTITY	Interleukin-7 promotes human regulatory T cell development at the CD4 + CD8 + double-positive thymocyte stage .
1970729	0	CD8	27,30	Interleukin_4	0,13	CD8	Interleukin 4	925	3565	Gene	Gene	CD4|dep|START_ENTITY +|dep|CD4 +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	CD8	35,38	Interleukin_4	0,13	CD8	Interleukin 4	925	3565	Gene	Gene	+|compound|START_ENTITY CD8|nmod|+ CD4|dep|CD8 +|dep|CD4 +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
16140789	0	CD8	69,72	KLRG1	45,50	CD8	KLRG1	925	10219	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation .
19406987	0	CD8	118,121	KLRG1	0,5	CD8	KLRG1	925	10219	Gene	Gene	cells|compound|START_ENTITY phosphorylation|nmod|cells induces|dobj|phosphorylation induces|nsubj|signaling signaling|compound|END_ENTITY	KLRG1 signaling induces defective Akt -LRB- ser473 -RRB- phosphorylation and proliferative dysfunction of highly differentiated CD8 + T cells .
23089397	0	CD8	53,56	KLRG1	26,31	CD8	KLRG1	925	10219	Gene	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of pulmonary KLRG1 -LRB- high -RRB- and KLRG1 -LRB- low -RRB- CD8 T cells to effector and memory responses during influenza_virus_infection .
24022692	0	CD8	9,12	KLRG1	74,79	CD8	KLRG1	925	10219	Gene	Gene	cells|compound|START_ENTITY driven|nsubjpass|cells driven|nmod|phenotype phenotype|compound|END_ENTITY	Expanded CD8 + T cells of murine and human CLL are driven into a senescent KLRG1 + effector memory phenotype .
11472411	0	CD8	72,75	L-selectin	15,25	CD8	L-selectin	925	6402	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Elevated serum L-selectin levels and decreased L-selectin expression on CD8 -LRB- + -RRB- lymphocytes in systemic_sclerosis .
22719212	0	CD8	106,109	L-selectin	83,93	CD8	L-selectin	925	6402	Gene	Gene	subset|compound|START_ENTITY subset|amod|END_ENTITY	Treatment with transcatheter arterial chemoembolization induces an increase of the L-selectin -LRB- low -RRB- CXCR3 + CD8 + T cell subset in patients with hepatocellular_carcinoma .
19483086	0	CD8	16,19	LFA-1	0,5	CD8	LFA-1	925	3689	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	LFA-1 regulates CD8 + T cell activation via T_cell_receptor-mediated and LFA-1-mediated Erk1/2 signal pathways .
26314621	0	CD8	102,105	LIR-1	96,101	CD8	LIR-1	925	10859	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Latent Cytomegalovirus_Infection in Rheumatoid_Arthritis and Increased Frequencies of Cytolytic LIR-1 + CD8 + T Cells .
1695560	0	CD8	4,7	Leu-7	9,14	CD8	Leu-7	925	27087	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	The CD8 + Leu-7 + subset of T cells in Crohn 's _ disease : distinction between cytotoxic and covert suppressor functions .
1696205	0	CD8	20,23	Leu-7	25,30	CD8	Leu-7	925	27087	Gene	Gene	+|compound|START_ENTITY +|dep|lymphocytes lymphocytes|nsubj|+ +|compound|END_ENTITY	Abnormally expanded CD8 + / Leu-7 + lymphocytes persisting in long-term bone marrow-transplanted patients are resting pre-cytotoxic T-lymphocytes .
1698559	0	CD8	60,63	Leu-7	65,70	CD8	Leu-7	925	27087	Gene	Gene	+|compound|START_ENTITY Induction|nmod|+ Induction|dep|cells cells|nummod|END_ENTITY	Induction of cytolytic function in resting peripheral blood CD8 + / Leu-7 + T cells through IL2/p 75 IL2-receptor interaction : a study in the allogeneic human bone marrow transplantation model .
8244777	0	CD8	37,40	Lymphokine	0,10	CD8	Lymphokine	925	3558	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Lymphokine gene transcription in CD4 + CD8 - T cells of a type_III_bare_lymphocyte_syndrome patient .
16971810	0	CD8	121,124	MART-1	105,111	CD8	MART-1	925	388015	Gene	Gene	immunity|compound|START_ENTITY immunity|amod|END_ENTITY	Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8 + T-cell immunity .
22768350	0	CD8	76,79	MART-1	58,64	CD8	MART-1	925	2315	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Human macrophages and dendritic cells can equally present MART-1 antigen to CD8 -LRB- + -RRB- T cells after phagocytosis of gamma-irradiated melanoma cells .
9378560	0	CD8	15,18	MART-1	59,65	CD8	MART-1	925	2315	Gene	Gene	responses|compound|START_ENTITY Stimulation|nmod|responses Stimulation|dep|END_ENTITY	Stimulation of CD8 + T cell responses to MAGE-3 and Melan_A / MART-1 by immunization to a polyvalent melanoma vaccine .
9850054	0	CD8	14,17	MART-1	101,107	CD8	MART-1	925	2315	Gene	Gene	+|compound|START_ENTITY Generation|nmod|+ +|nsubj|Generation +|nmod|cells cells|amod|engineered engineered|xcomp|express express|dobj|gene gene|compound|END_ENTITY	Generation of CD8 + and CD4 + T-cell response to dendritic cells genetically engineered to express the MART-1 / Melan-A gene .
16491076	0	CD8	23,26	MAZR	103,107	CD8	MAZR	925	23598	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR .
9850054	0	CD8	14,17	Melan-A	108,115	CD8	Melan-A	925	2315	Gene	Gene	+|compound|START_ENTITY Generation|nmod|+ +|nsubj|Generation +|nmod|cells cells|amod|engineered engineered|xcomp|express express|dobj|gene gene|compound|END_ENTITY	Generation of CD8 + and CD4 + T-cell response to dendritic cells genetically engineered to express the MART-1 / Melan-A gene .
19414781	0	CD8	45,48	MyD88	21,26	CD8	MyD88	925	4615	Gene	Gene	responses|compound|START_ENTITY promotes|dobj|responses promotes|nsubj|END_ENTITY	The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia_virus .
18830408	0	CD8	22,25	N1L	77,80	CD8	N1L	925	3707643(Tax:10245)	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia_virus .
15517612	0	CD8	105,108	NKG2A	42,47	CD8	NKG2A	925	3821	Gene	Gene	lymphocytes|compound|START_ENTITY subsets|nmod|lymphocytes expressed|nmod|subsets expressed|nsubjpass|receptors receptors|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
18064301	0	CD8	17,20	NKG2A	35,40	CD8	NKG2A	925	3821	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Small intestinal CD8 + TCRgammadelta + NKG2A + intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac_disease .
18500933	0	CD8	93,96	NKG2A	87,92	CD8	NKG2A	925	3821	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Hepatitis_C virus-induced secretion of inflammatory chemokines preferentially recruits NKG2A + CD8 + T cells .
21538351	0	CD8	66,69	NKG2A	0,5	CD8	NKG2A	925	3821	Gene	Gene	cells|compound|START_ENTITY function|nmod|cells acquisition|nmod|function marker|nmod|acquisition marker|nsubj|END_ENTITY	NKG2A is a marker for acquisition of regulatory function by human CD8 + T cells activated with anti-CD3 antibody .
15699119	0	CD8	116,119	NKG2D	14,19	CD8	NKG2D	925	22914	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells mediate|dobj|costimulation insufficient|xcomp|mediate insufficient|nsubj|Engagement Engagement|nmod|END_ENTITY	Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8 + T cells .
16116168	0	CD8	44,47	NKG2D	100,105	CD8	NKG2D	925	27007(Tax:10090)	Gene	Gene	function|compound|START_ENTITY Costimulation|nmod|function Costimulation|dep|similarities similarities|nmod|costimulation costimulation|compound|END_ENTITY	Costimulation through NKG2D enhances murine CD8 + CTL function : similarities and differences between NKG2D and CD28 costimulation .
16116168	0	CD8	44,47	NKG2D	22,27	CD8	NKG2D	925	27007(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Costimulation through NKG2D enhances murine CD8 + CTL function : similarities and differences between NKG2D and CD28 costimulation .
17255258	0	CD8	30,33	NKG2D	10,15	CD8	NKG2D	925	22914	Gene	Gene	cell|compound|START_ENTITY expression|nmod|cell expression|compound|END_ENTITY	Decreased NKG2D expression on CD8 + T cell is involved in immune evasion in patients with gastric_cancer .
18024793	0	CD8	56,59	NKG2D	16,21	CD8	NKG2D	925	22914	Gene	Gene	cells|compound|START_ENTITY costimulation|nmod|cells costimulation|nummod|END_ENTITY	4-1BB regulates NKG2D costimulation in human cord blood CD8 + T cells .
18564160	0	CD8	48,51	NKG2D	28,33	CD8	NKG2D	925	22914	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Inverse correlation between NKG2D expression on CD8 + T cells and the frequency of CD4 + CD25 + regulatory T cells in patients with esophageal_cancer .
19089424	0	CD8	18,21	NKG2D	11,16	CD8	NKG2D	925	22914	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TNK cells -LRB- NKG2D + CD8 + or CD4 + T lymphocytes -RRB- in the control of human tumors .
19124832	0	CD8	9,12	NKG2D	74,79	CD8	NKG2D	925	22914	Gene	Gene	lymphocytes|nummod|START_ENTITY Detuning|dobj|lymphocytes Detuning|nmod|down-regulation down-regulation|nmod|END_ENTITY	Detuning CD8 + T lymphocytes by down-regulation of the activating receptor NKG2D : role of NKG2D ligands released by activated T cells .
19124832	0	CD8	9,12	NKG2D	89,94	CD8	NKG2D	925	22914	Gene	Gene	lymphocytes|nummod|START_ENTITY Detuning|dobj|lymphocytes role|dep|Detuning role|nmod|ligands ligands|nummod|END_ENTITY	Detuning CD8 + T lymphocytes by down-regulation of the activating receptor NKG2D : role of NKG2D ligands released by activated T cells .
22366950	0	CD8	19,22	NKG2D	0,5	CD8	NKG2D	925	22914	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	NKG2D signaling on CD8 T cells represses T-bet and rescues CD4-unhelped CD8 T cell memory recall but not effector responses .
22640649	0	CD8	33,36	NKG2D	14,19	CD8	NKG2D	925	22914	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of NKG2D and CD107 in CD8 -LRB- + -RRB- effector memory lymphocytes in Churg-Strauss_syndrome .
22942430	0	CD8	58,61	NKG2D	23,28	CD8	NKG2D	925	22914	Gene	Gene	IL-4|nmod|START_ENTITY expression|nmod|IL-4 expression|nummod|END_ENTITY	Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells .
22975165	0	CD8	61,64	NKG2D	51,56	CD8	NKG2D	925	22914	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adoptive cellular therapy using cells enriched for NKG2D + CD3 + CD8 + T cells after autologous transplantation for myeloma .
23018378	0	CD8	33,36	NKG2D	0,5	CD8	NKG2D	925	22914	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	NKG2D expression on HIV-specific CD8 + T cells is reduced in viremic_HIV-1-infected patients but maintained in HIV controllers .
23235109	0	CD8	109,112	NKG2D	89,94	CD8	NKG2D	925	22914	Gene	Gene	T|compound|START_ENTITY gene|nmod|T gene|compound|END_ENTITY	DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8 + T and NK cells .
23804716	0	CD8	56,59	NKG2D	0,5	CD8	NKG2D	925	22914	Gene	Gene	precursors|nummod|START_ENTITY expression|nmod|precursors induces|dobj|expression induces|nsubj|END_ENTITY	NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase .
23922903	0	CD8	40,43	NKG2D	14,19	CD8	NKG2D	925	22914	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Modulation of NKG2D expression in human CD8 -LRB- + -RRB- T cells corresponding with tuberculosis drug cure .
24168855	0	CD8	48,51	NKG2D	0,5	CD8	NKG2D	925	22914	Gene	Gene	chemotaxis|compound|START_ENTITY chemotaxis|amod|END_ENTITY	NKG2D - and CD28-mediated costimulation regulate CD8 + T cell chemotaxis through different mechanisms : the role of Cdc42/N-WASp .
24586170	0	CD8	40,43	NKG2D	14,19	CD8	NKG2D	925	22914	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania_major_infection .
25788701	0	CD8	20,23	NKG2D	0,5	CD8	NKG2D	925	27007(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	NKG2D expression by CD8 + T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT .
26290604	0	CD8	65,68	NKG2D	59,64	CD8	NKG2D	925	27007(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Lymphocytic_Choriomeningitis Virus Expands a Population of NKG2D + CD8 + T Cells That Exacerbate Disease in Mice Coinfected with Leishmania_major .
26509932	0	CD8	48,51	NKG2D	27,32	CD8	NKG2D	925	22914	Gene	Gene	Cells|compound|START_ENTITY Impaired|nmod|Cells Impaired|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression and Function of NKG2D Is Impaired in CD8 + T Cells of Chronically_HIV-1-Infected Patients Without ART .
17303697	0	CD8	36,39	NKa	31,34	CD8	NKa	925	6863	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Monoclonal TCR-Vbeta13 .1 + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis : evidence for an antigen-driven chronic T-cell stimulation origin .
18768393	0	CD8	54,57	NKa	49,52	CD8	NKa	925	6863	Gene	Gene	+|dep|START_ENTITY END_ENTITY|dep|+	Expanded cells in monoclonal TCR-alphabeta + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis recognize hCMV antigens .
20739776	0	CD8	14,17	NKa	7,10	CD8	NKa	925	6863	Gene	Gene	T-cell_large_granular_lymphocytic_leukemia|compound|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|dep|+ +|compound|END_ENTITY	CD4 + / NKa _ + / CD8 -LRB- dim + -RRB- T-cell_large_granular_lymphocytic_leukemia : a rare entity .
26630176	0	CD8	44,47	NKp46	0,5	CD8	NKp46	925	9437	Gene	Gene	Cell|compound|START_ENTITY Cell|compound|END_ENTITY	NKp46 + Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine .
18523634	0	CD8	13,16	NS1	0,3	CD8	NS1	925	10625	Gene	Gene	T-cells|compound|START_ENTITY T-cells|nummod|END_ENTITY	NS1 specific CD8 + T-cells with effector function and TRBV11 dominance in a patient with parvovirus_B19 associated inflammatory_cardiomyopathy .
10781081	0	CD8	11,14	NY-ESO-1	35,43	CD8	NY-ESO-1	925	246100	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Monitoring CD8 T cell responses to NY-ESO-1 : correlation of humoral and cellular immune responses .
10969798	0	CD8	59,62	NY-ESO-1	109,117	CD8	NY-ESO-1	925	246100	Gene	Gene	response|compound|START_ENTITY occurring|dobj|response occurring|nsubj|END_ENTITY	Naturally occurring human lymphocyte antigen-A2 restricted CD8 + T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients .
11027314	0	CD8	40,43	NY-ESO-1	117,125	CD8	NY-ESO-1	925	246100	Gene	Gene	lymphocyte|compound|START_ENTITY lymphocyte|nmod|patients patients|nmod|cancers cancers|compound|END_ENTITY	Induction of primary NY-ESO-1 immunity : CD8 + T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1 + cancers .
11027314	0	CD8	40,43	NY-ESO-1	21,29	CD8	NY-ESO-1	925	246100	Gene	Gene	lymphocyte|compound|START_ENTITY Induction|dep|lymphocyte Induction|nmod|immunity immunity|compound|END_ENTITY	Induction of primary NY-ESO-1 immunity : CD8 + T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1 + cancers .
11300471	0	CD8	0,3	NY-ESO-1	24,32	CD8	NY-ESO-1	925	246100	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	CD8 + T-cell response to NY-ESO-1 : relative antigenicity and in vitro immunogenicity of natural and analogue sequences .
12186971	0	CD8	0,3	NY-ESO-1	72,80	CD8	NY-ESO-1	925	246100	Gene	Gene	T|nsubj|START_ENTITY T|nmod|immunization immunization|compound|END_ENTITY	CD8 -LRB- + -RRB- T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients .
12488431	0	CD8	13,16	NY-ESO-1	41,49	CD8	NY-ESO-1	925	246100	Gene	Gene	T|nsubj|START_ENTITY T|nmod|results results|amod|peptide peptide|amod|END_ENTITY	Multiepitope CD8 -LRB- + -RRB- T cell response to a NY-ESO-1 peptide vaccine results in imprecise tumor targeting .
12747757	0	CD8	71,74	NY-ESO-1	40,48	CD8	NY-ESO-1	925	246100	Gene	Gene	cells|compound|START_ENTITY recognized|nmod|cells recognized|nsubj|Identification Identification|nmod|peptide peptide|compound|END_ENTITY	Identification of a naturally processed NY-ESO-1 peptide recognized by CD8 + T cells in the context of HLA-B51 .
15600300	0	CD8	102,105	NY-ESO-1	35,43	CD8	NY-ESO-1	925	246100	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
15838382	0	CD8	82,85	NY-ESO-1	134,142	CD8	NY-ESO-1	925	246100	Gene	Gene	responses|compound|START_ENTITY occurring|nmod|responses occurring|nmod|END_ENTITY	Distinct structural TCR repertoires in naturally occurring versus vaccine-induced CD8 + T-cell responses to the tumor-specific antigen NY-ESO-1 .
16378102	0	CD8	74,77	NY-ESO-1	18,26	CD8	NY-ESO-1	925	246100	Gene	Gene	cells|compound|START_ENTITY line|nmod|cells line|nsubj|Estimation Estimation|nmod|cell cell|compound|END_ENTITY	-LSB- Estimation of an NY-ESO-1 expressing HCC cell line by NY-ESO-1b specific CD8 + T cells in vitro induced by HLA-A2 restricted NY-ESO-1b peptide -RSB- .
16670298	0	CD8	58,61	NY-ESO-1	106,114	CD8	NY-ESO-1	925	246100	Gene	Gene	+|compound|START_ENTITY hierarchy|nmod|+ T|nsubj|hierarchy T|nmod|END_ENTITY	Striking immunodominance hierarchy of naturally occurring CD8 + and CD4 + T cell responses to tumor antigen NY-ESO-1 .
17294444	0	CD8	89,92	NY-ESO-1	0,8	CD8	NY-ESO-1	925	246100	Gene	Gene	T-cell|compound|START_ENTITY correlation|nmod|T-cell expression|dep|correlation expression|compound|END_ENTITY	NY-ESO-1 protein expression in primary breast_carcinoma and metastases : correlation with CD8 + T-cell and CD79a + plasmacytic/B-cell infiltration .
17640060	0	CD8	15,18	NY-ESO-1	52,60	CD8	NY-ESO-1	925	246100	Gene	Gene	+|nsubj|START_ENTITY +|nmod|vaccination vaccination|compound|END_ENTITY	Tumor-reactive CD8 + T-cell clones in patients after NY-ESO-1 peptide vaccination .
18253733	0	CD8	63,66	NY-ESO-1	137,145	CD8	NY-ESO-1	925	246100	Gene	Gene	epitopes|nummod|START_ENTITY reactive|dobj|epitopes reactive|nmod|region region|nmod|END_ENTITY	Recognition of naturally processed and ovarian_cancer reactive CD8 + T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1 .
19728336	0	CD8	15,18	NY-ESO-1	60,68	CD8	NY-ESO-1	925	246100	Gene	Gene	+|nsubj|START_ENTITY +|nmod|peptide peptide|compound|END_ENTITY	Tumor-reactive CD8 + T-cell responses after vaccination with NY-ESO-1 peptide , CpG_7909 and Montanide ISA-51 : association with survival .
21149605	0	CD8	86,89	NY-ESO-1	18,26	CD8	NY-ESO-1	925	246100	Gene	Gene	+|compound|START_ENTITY elicits|dobj|+ elicits|nsubj|END_ENTITY	Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8 + and CD4 + T cell responses with broad antigen specificity .
22729530	0	CD8	13,16	NY-ESO-1	138,146	CD8	NY-ESO-1	925	246100	Gene	Gene	responses|compound|START_ENTITY responses|acl|restricted restricted|nmod|immunization immunization|nmod|NY-ESO-1f NY-ESO-1f|appos|END_ENTITY	Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f -LRB- NY-ESO-1 91-110 -RRB- peptide .
22128144	0	CD8	25,28	Nab2	0,4	CD8	Nab2	925	4665	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	Nab2 regulates secondary CD8 + T-cell responses through control of TRAIL expression .
16904156	0	CD8	41,44	Nef	26,29	CD8	Nef	925	6285	Gene	Gene	cells|compound|START_ENTITY protein|nmod|cells protein|compound|END_ENTITY	Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children : impact of age .
15685176	0	CD8	42,45	PD-1	72,76	CD8	PD-1	925	5133	Gene	Gene	tolerance|compound|START_ENTITY tolerance|nmod|END_ENTITY	Resting dendritic cells induce peripheral CD8 + T cell tolerance through PD-1 and CTLA-4 .
16956940	0	CD8	91,94	PD-1	0,4	CD8	PD-1	925	5133	Gene	Gene	exhaustion|compound|START_ENTITY associated|nmod|exhaustion associated|nsubjpass|expression expression|compound|END_ENTITY	PD-1 expression in acute hepatitis_C_virus _ -LRB- HCV -RRB- infection is associated with HCV-specific CD8 exhaustion .
18549878	0	CD8	39,42	PD-1	54,58	CD8	PD-1	925	5133	Gene	Gene	cells|compound|START_ENTITY cells|nmod|blockade blockade|compound|END_ENTITY	Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization .
18549878	0	CD8	39,42	PD-1	82,86	CD8	PD-1	925	5133	Gene	Gene	cells|compound|START_ENTITY restoration|nmod|cells defined|nsubjpass|restoration defined|nmod|expression expression|compound|END_ENTITY	Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization .
19247441	0	CD8	50,53	PD-1	84,88	CD8	PD-1	925	5133	Gene	Gene	cell|compound|START_ENTITY reversal|nmod|cell exhaustion|nsubj|reversal exhaustion|nmod|blockade blockade|compound|END_ENTITY	Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1 / CTLA-4 blockade .
19395117	0	CD8	72,75	PD-1	20,24	CD8	PD-1	925	5133	Gene	Gene	development|compound|START_ENTITY correlates|nmod|development correlates|nsubj|decrease decrease|nmod|expression expression|compound|END_ENTITY	Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis_B patients .
19595077	0	CD8	57,60	PD-1	1,5	CD8	PD-1	925	5133	Gene	Gene	cells|compound|START_ENTITY apoptosis|nmod|cells influenced|dobj|apoptosis influenced|nsubj|up-regulation up-regulation|compound|END_ENTITY	-LSB- PD-1 up-regulation influenced apoptosis of HBV-specific CD8 T cells in patients with acute resolved hepatitis_B -RSB- .
20473887	0	CD8	37,40	PD-1	0,4	CD8	PD-1	925	5133	Gene	Gene	promotes|dobj|START_ENTITY promotes|nsubj|upregulation upregulation|amod|END_ENTITY	PD-1 and PD-L1 upregulation promotes CD8 -LRB- + -RRB- T-cell apoptosis and postoperative recurrence in hepatocellular_carcinoma patients .
21070674	0	CD8	30,33	PD-1	0,4	CD8	PD-1	925	100037293(Tax:9823)	Gene	Gene	subsets|compound|START_ENTITY expression|nmod|subsets expression|compound|END_ENTITY	PD-1 expression on peripheral CD8 + TEM/TEMRA subsets closely correlated with HCV viral load in chronic_hepatitis_C patients .
22067141	0	CD8	57,60	PD-1	73,77	CD8	PD-1	925	5133	Gene	Gene	cells|compound|START_ENTITY cells|nmod|expression expression|compound|END_ENTITY	Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple_sclerosis .
22144176	0	CD8	93,96	PD-1	39,43	CD8	PD-1	925	5133	Gene	Gene	cells|compound|START_ENTITY exhausted|dobj|cells impairment|acl|exhausted impairment|dep|Reduced Reduced|nmod|END_ENTITY	Reduced tumor-antigen density leads to PD-1 / PD-L1-mediated impairment of partially exhausted CD8 T cells .
22797302	0	CD8	48,51	PD-1	69,73	CD8	PD-1	925	5133	Gene	Gene	cells|nummod|START_ENTITY impair|dobj|cells impair|nmod|END_ENTITY	Viral acute lower respiratory_infections impair CD8 + T cells through PD-1 .
23324275	0	CD8	45,48	PD-1	52,56	CD8	PD-1	925	5133	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Frequency of T-cell FoxP3 Treg and CD4 / CD8 PD-1 expression is related to HBeAg seroconversion in hepatitis_B patients on pegylated interferon .
24021877	0	CD8	100,103	PD-1	132,136	CD8	PD-1	925	18566(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY deletion|nmod|cells deletion|nmod|END_ENTITY	DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1 .
24590765	0	CD8	18,21	PD-1	43,47	CD8	PD-1	925	5133	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral_infection .
24667641	0	CD8	37,40	PD-1	0,4	CD8	PD-1	925	5133	Gene	Gene	repertoire|compound|START_ENTITY identifies|dobj|repertoire identifies|nsubj|END_ENTITY	PD-1 identifies the patient-specific CD8 tumor-reactive repertoire infiltrating human tumors .
25707450	0	CD8	70,73	PD-1	12,16	CD8	PD-1	925	5133	Gene	Gene	T-cell|nsubj|START_ENTITY enhances|dep|T-cell enhances|nsubj|Blockade Blockade|nmod|kinase kinase|compound|END_ENTITY	Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8 -LRB- + -RRB- T-cell proliferation by distinct pathways .
25901287	0	CD8	97,100	PD-1	42,46	CD8	PD-1	925	5133	Gene	Gene	cell|compound|START_ENTITY unleashing|dobj|cell disrupting|dep|unleashing disrupting|dobj|checkpoint checkpoint|compound|END_ENTITY	The therapeutic promise of disrupting the PD-1 / PD-L1 immune checkpoint in cancer : unleashing the CD8 T cell mediated anti-tumor activity results in significant , unprecedented clinical efficacy in various solid tumors .
25957117	0	CD8	82,85	PD-1	0,4	CD8	PD-1	925	5133	Gene	Gene	Cells|compound|START_ENTITY Coexpressed|nmod|Cells Coexpressed|nsubjpass|END_ENTITY	PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian_Cancer .
26235847	0	CD8	56,59	PD-1	47,51	CD8	PD-1	925	5133	Gene	Gene	lymphocytes|amod|START_ENTITY identifies|nsubj|lymphocytes ratio|parataxis|identifies ratio|nmod|programmed_cell_death_protein_1 programmed_cell_death_protein_1|appos|END_ENTITY	High ratio of programmed_cell_death_protein_1 -LRB- PD-1 -RRB- -LRB- + -RRB- / CD8 -LRB- + -RRB- tumor-infiltrating lymphocytes identifies a poor prognostic subset of extrahepatic_bile_duct cancer undergoing surgery plus adjuvant chemoradiotherapy .
26912627	0	CD8	37,40	PD-1	89,93	CD8	PD-1	925	5133	Gene	Gene	responses|nummod|START_ENTITY associated|nsubjpass|responses associated|nmod|phenotype phenotype|compound|END_ENTITY	Immunodominant dengue virus specific CD8 + T cells responses are associated with a memory PD-1 + phenotype .
25901287	0	CD8	97,100	PD-L1	47,52	CD8	PD-L1	925	29126	Gene	Gene	cell|compound|START_ENTITY unleashing|dobj|cell disrupting|dep|unleashing disrupting|dobj|checkpoint checkpoint|compound|END_ENTITY	The therapeutic promise of disrupting the PD-1 / PD-L1 immune checkpoint in cancer : unleashing the CD8 T cell mediated anti-tumor activity results in significant , unprecedented clinical efficacy in various solid tumors .
17440051	0	CD8	13,16	PD1	49,52	CD8	PD1	925	5133	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|levels levels|nmod|END_ENTITY	SIV-specific CD8 + T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection .
22503210	0	CD8	40,43	PD1	87,90	CD8	PD1	925	5133	Gene	Gene	cells|nsubj|START_ENTITY cells|acl|modified modified|xcomp|express express|dobj|END_ENTITY	Tumor PD-L1 co-stimulates primary human CD8 -LRB- + -RRB- cytotoxic T cells modified to express a PD1 : CD28 chimeric receptor .
23587922	0	CD8	41,44	PD1	75,78	CD8	PD1	925	5133	Gene	Gene	immunity|compound|START_ENTITY Potentiating|dobj|immunity Potentiating|nmod|vaccine vaccine|compound|END_ENTITY	Potentiating functional antigen-specific CD8 T cell immunity by a novel PD1 isoform-based fusion DNA vaccine .
26154582	0	CD8	12,15	PD1	63,66	CD8	PD1	925	18566(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Role|nmod|Cells Role|nmod|END_ENTITY	The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1 - / - Mice Cotreated with Anti-CTLA-4 .
26208901	0	CD8	32,35	PD1	44,47	CD8	PD1	925	100037293(Tax:9823)	Gene	Gene	Level|nmod|START_ENTITY +|nsubj|Level +|dobj|Response Response|compound|END_ENTITY	A Threshold Level of Intratumor CD8 + T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1 .
27038842	0	CD8	30,33	PD1	35,38	CD8	PD1	925	5133	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD103 defines intraepithelial CD8 + PD1 + tumour-infiltrating lymphocytes of prognostic significance in endometrial_adenocarcinoma .
23734332	0	CD8	35,38	PRAME	11,16	CD8	PRAME	925	23532	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	Priming of PRAME - and WT1-specific CD8 -LRB- + -RRB- T cells in healthy donors but not in AML patients in complete remission : Implications for immunotherapy .
25238774	0	CD8	33,36	PRF1	27,31	CD8	PRF1	925	5551	Gene	Gene	Response|compound|START_ENTITY Response|compound|END_ENTITY	IFNy-TNFa-IL2-MIP1a-CD107a + PRF1 + CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans .
19483644	0	CD8	100,103	PSA	142,145	CD8	PSA	925	354	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Vaccination with agonist peptide PSA : 154-163 -LRB- 155L -RRB- derived from prostate_specific_antigen induced CD8 T-cell response to the native peptide PSA : 154-163 but failed to induce the reactivity against tumor targets expressing PSA : a phase 2 study in patients with recurrent prostate_cancer .
19483644	0	CD8	100,103	PSA	224,227	CD8	PSA	925	354	Gene	Gene	response|compound|START_ENTITY response|dep|154-163 154-163|acl|failed failed|xcomp|induce induce|nmod|targets targets|acl|expressing expressing|dobj|END_ENTITY	Vaccination with agonist peptide PSA : 154-163 -LRB- 155L -RRB- derived from prostate_specific_antigen induced CD8 T-cell response to the native peptide PSA : 154-163 but failed to induce the reactivity against tumor targets expressing PSA : a phase 2 study in patients with recurrent prostate_cancer .
19483644	0	CD8	100,103	PSA	33,36	CD8	PSA	925	354	Gene	Gene	response|compound|START_ENTITY induced|dobj|response prostate_specific_antigen|acl|induced derived|nmod|prostate_specific_antigen 154-163|acl|derived Vaccination|dep|154-163 Vaccination|nmod|END_ENTITY	Vaccination with agonist peptide PSA : 154-163 -LRB- 155L -RRB- derived from prostate_specific_antigen induced CD8 T-cell response to the native peptide PSA : 154-163 but failed to induce the reactivity against tumor targets expressing PSA : a phase 2 study in patients with recurrent prostate_cancer .
25597827	0	CD8	23,26	Preproinsulin	0,13	CD8	Preproinsulin	925	3630	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Preproinsulin specific CD8 + T cells in subjects with latent autoimmune diabetes show lower frequency and different pathophysiological characteristics than those with type_1_diabetes .
14975243	0	CD8	6,9	RANTES	25,31	CD8	RANTES	925	6352	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|store store|dobj|END_ENTITY	Human CD8 + T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation .
18715802	0	CD8	14,17	RARgamma	41,49	CD8	RARgamma	925	5916	Gene	Gene	Regulation|nmod|START_ENTITY T|nsubj|Regulation T|nmod|END_ENTITY	Regulation of CD8 -LRB- + -RRB- T cell functions by RARgamma .
20007535	0	CD8	69,72	RasGRP1	0,7	CD8	RasGRP1	925	10125	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells .
16210337	0	CD8	56,59	STAT1	14,19	CD8	STAT1	925	6772	Gene	Gene	responses|compound|START_ENTITY shaping|dobj|responses mechanism|acl|shaping Modulation|dep|mechanism Modulation|nmod|levels levels|compound|END_ENTITY	Modulation of STAT1 protein levels : a mechanism shaping CD8 T-cell responses in vivo .
18250422	0	CD8	19,22	STAT1	0,5	CD8	STAT1	925	6772	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	STAT1 signaling in CD8 T cells is required for their clonal expansion and memory_formation_following_viral_infection in vivo .
23830147	0	CD8	131,134	STAT3	52,57	CD8	STAT3	925	6774	Gene	Gene	mutations|dobj|START_ENTITY mutations|nsubj|Signal_transducer_and_activator_of_transcription_3 Signal_transducer_and_activator_of_transcription_3|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- mutations underlying autosomal dominant hyper-IgE_syndrome impair human CD8 -LRB- + -RRB- T-cell memory formation and function .
24204098	0	CD8	46,49	STAT3	0,5	CD8	STAT3	925	6774	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells regulates|dobj|proliferation regulates|nsubj|END_ENTITY	STAT3 regulates proliferation and survival of CD8 + T cells : enhances effector responses to HSV-1_infection , and inhibits IL-10 + regulatory CD8 + T cells in autoimmune uveitis .
26025380	0	CD8	9,12	STAT3	0,5	CD8	STAT3	925	6774	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	STAT3 in CD8 + T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis .
23922331	0	CD8	72,75	STIM1	0,5	CD8	STIM1	925	6786	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	STIM1 and STIM2-mediated Ca -LRB- 2 + -RRB- influx regulates antitumour immunity by CD8 -LRB- + -RRB- T cells .
26714260	0	CD8	53,56	T-Bet	28,33	CD8	T-Bet	925	30009	Gene	Gene	Cells|compound|START_ENTITY Eomesodermin|nmod|Cells Regulates|nmod|Eomesodermin Regulates|dobj|Ratio Ratio|nmod|END_ENTITY	IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8 + T Cells Responding to Persistent LCMV Infection .
15096540	0	CD8	30,33	T-bet	0,5	CD8	T-bet	925	30009	Gene	Gene	responses|nummod|START_ENTITY autoaggressive|dobj|responses autoaggressive|nsubj|controls controls|amod|END_ENTITY	T-bet controls autoaggressive CD8 lymphocyte responses in type_1_diabetes .
17723210	0	CD8	0,3	T-bet	55,60	CD8	T-bet	925	30009	Gene	Gene	T|nsubj|START_ENTITY T|parataxis|choosing choosing|nmod|END_ENTITY	CD8 -LRB- + -RRB- T cell differentiation : choosing a path through T-bet .
21177324	0	CD8	28,31	T-bet	32,37	CD8	T-bet	925	30009	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + T-bet + , CD4 + pSTAT3 + and CD8 + T-bet + T cells accumulate in peripheral blood during NZB treatment .
21289310	0	CD8	23,26	T-bet	99,104	CD8	T-bet	925	30009	Gene	Gene	potential|compound|START_ENTITY associated|nsubjpass|potential associated|nmod|expression expression|amod|END_ENTITY	Increased HIV-specific CD8 + T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression .
23440501	0	CD8	74,77	T-bet	10,15	CD8	T-bet	925	30009	Gene	Gene	cells|compound|START_ENTITY senescence|nmod|cells associated|nmod|senescence associated|nsubjpass|END_ENTITY	Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans .
23455505	0	CD8	48,51	T-bet	29,34	CD8	T-bet	925	30009	Gene	Gene	populations|compound|START_ENTITY localization|nmod|populations localization|nmod|END_ENTITY	Differential localization of T-bet and Eomes in CD8 T cell memory populations .
23479229	0	CD8	15,18	T-bet	62,67	CD8	T-bet	925	30009	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	IL-21 promotes CD8 + CTL activity via the transcription factor T-bet .
25225458	0	CD8	14,17	T-bet	96,101	CD8	T-bet	925	30009	Gene	Gene	cells|compound|START_ENTITY characterized|nsubjpass|cells characterized|nmod|lack lack|nmod|induction induction|amod|END_ENTITY	Dysfunctional CD8 + T cells in hepatitis_B and C are characterized by a lack of antigen-specific T-bet induction .
25516478	0	CD8	114,117	T-bet	44,49	CD8	T-bet	925	30009	Gene	Gene	cells|compound|START_ENTITY induce|nmod|cells relies|xcomp|induce relies|nmod|END_ENTITY	Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8 + T cells .
11133763	0	CD8	53,56	T-cell_receptor	25,40	CD8	T-cell receptor	925	6962	Gene	Gene	T|compound|START_ENTITY use|nmod|T use|nsubj|analysis analysis|nmod|gene gene|amod|END_ENTITY	Longitudinal analysis of T-cell_receptor gene use by CD8 -LRB- + -RRB- T cells in early human_immunodeficiency_virus_infection in patients receiving highly active antiretroviral therapy .
11157474	0	CD8	210,213	T-cell_receptor	177,192	CD8	T-cell receptor	925	6962	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Interferon-inducible_protein_10 , monokine_induced_by_interferon_gamma , and interferon-inducible_T-cell_alpha_chemoattractant are produced by thymic epithelial cells and attract T-cell_receptor -LRB- TCR -RRB- alphabeta + CD8 + single-positive T cells , TCRgammadelta + T cells , and natural killer-type cells in human thymus .
12888876	0	CD8	127,130	T-cell_receptor	81,96	CD8	T-cell receptor	925	6962	Gene	Gene	T-cell|compound|START_ENTITY usage|nmod|T-cell usage|amod|END_ENTITY	Replacement therapy with plasma-derived factor_VIII concentrates induces skew in T-cell_receptor usage and clonal expansion of CD8 + T-cell in HIV-seronegative hemophilia patients .
16367910	0	CD8	105,108	T-cell_receptor	73,88	CD8	T-cell receptor	925	6962	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Regulatory balance between the immune response of tumor antigen-specific T-cell_receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells .
16638844	0	CD8	76,79	T-cell_receptor	19,34	CD8	T-cell receptor	925	6962	Gene	Gene	T|compound|START_ENTITY profile|nmod|T profile|amod|END_ENTITY	Alterations in the T-cell_receptor variable beta gene-restricted profile of CD8 + T lymphocytes in the peripheral circulation of patients with squamous_cell_carcinoma_of_the_head_and_neck .
21606376	0	CD8	85,88	T-cell_receptor	30,45	CD8	T-cell receptor	925	6962	Gene	Gene	enabling|nmod|START_ENTITY enabling|dobj|diversity diversity|amod|END_ENTITY	Structural basis for enabling T-cell_receptor diversity within biased virus-specific CD8 + T-cell responses .
22898597	0	CD8	51,54	T-cell_receptor	0,15	CD8	T-cell receptor	925	6962	Gene	Gene	human|dep|START_ENTITY cells|amod|human exclusively|nmod|cells enhances|advmod|exclusively enhances|nsubj|transfer transfer|amod|END_ENTITY	T-cell_receptor gene transfer exclusively to human CD8 -LRB- + -RRB- cells enhances tumor cell killing .
24091848	0	CD8	54,57	T-cell_receptor	83,98	CD8	T-cell receptor	925	6962	Gene	Gene	T|nsubj|START_ENTITY T|dobj|cells cells|nmod|END_ENTITY	In vitro generation of mature , naive antigen-specific CD8 -LRB- + -RRB- T cells with a single T-cell_receptor by agonist selection .
24149287	0	CD8	53,56	T-cell_receptor	23,38	CD8	T-cell receptor	925	6962	Gene	Gene	lymphocyte_leukemia|compound|START_ENTITY repertoire|nmod|lymphocyte_leukemia repertoire|amod|END_ENTITY	Deep sequencing of the T-cell_receptor repertoire in CD8 + T-large granular lymphocyte_leukemia identifies signature landscapes .
27040081	0	CD8	0,3	T-cell_receptor	80,95	CD8	T-cell receptor	925	6962	Gene	Gene	T-cell|compound|START_ENTITY elucidated|nsubj|T-cell elucidated|nmod|sequencing sequencing|amod|END_ENTITY	CD8 -LRB- + -RRB- T-cell pathogenicity in Rasmussen_encephalitis elucidated by large-scale T-cell_receptor sequencing .
8381310	0	CD8	22,25	T-cell_receptor	105,120	CD8	T-cell receptor	925	6962	Gene	Gene	-|compound|START_ENTITY CD4|dep|- Double-negative|dep|CD4 cells|amod|Double-negative have|nsubj|cells have|dobj|expression expression|nmod|complex complex|compound|END_ENTITY	Double-negative -LRB- CD4 - CD8 - -RRB- T cells from adult_T-cell_leukemia patients also have poor expression of the T-cell_receptor alpha beta/CD3 complex .
8970681	0	CD8	13,16	T-cell_receptor	51,66	CD8	T-cell receptor	925	6962	Gene	Gene	expansions|compound|START_ENTITY expansions|nmod|usage usage|compound|END_ENTITY	Detection of CD8 T-cell expansions with restricted T-cell_receptor V gene usage in infants vertically infected by HIV-1 .
9744753	0	CD8	125,128	T-cell_receptor	28,43	CD8	T-cell receptor	925	6962	Gene	Gene	expansions|compound|START_ENTITY analysis|dep|expansions analysis|nmod|repertoires repertoires|amod|END_ENTITY	High-resolution analysis of T-cell_receptor beta-chain repertoires using DNA heteroduplex tracking : generally stable , clonal CD8 + expansions in all healthy young adults .
10352247	0	CD8	117,120	TCR	175,178	CD8	TCR	925	6962	Gene	Gene	compensating|compound|START_ENTITY compensating|nmod|differences differences|nmod|affinities affinities|compound|END_ENTITY	Selection and long-term persistence of reactive CTL clones during an EBV chronic response are determined by avidity , CD8 variable contribution compensating for differences in TCR affinities .
11157474	0	CD8	210,213	TCR	194,197	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY cells|appos|END_ENTITY	Interferon-inducible_protein_10 , monokine_induced_by_interferon_gamma , and interferon-inducible_T-cell_alpha_chemoattractant are produced by thymic epithelial cells and attract T-cell_receptor -LRB- TCR -RRB- alphabeta + CD8 + single-positive T cells , TCRgammadelta + T cells , and natural killer-type cells in human thymus .
11165713	0	CD8	25,28	TCR	0,3	CD8	TCR	925	6962	Gene	Gene	cells|nummod|START_ENTITY protects|dobj|cells protects|nsubj|stimulation stimulation|compound|END_ENTITY	TCR stimulation protects CD8 + T cells from CD95 mediated apoptosis .
11675369	0	CD8	68,71	TCR	55,58	CD8	TCR	925	6962	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|nmod|responses	Influenza A antigen exposure selects dominant Vbeta17 + TCR in human CD8 + cytotoxic T cell responses .
12496422	0	CD8	56,59	TCR	27,30	CD8	TCR	925	6962	Gene	Gene	recruits|dobj|START_ENTITY xenoreactive|parataxis|recruits xenoreactive|dobj|END_ENTITY	High affinity xenoreactive TCR : MHC interaction recruits CD8 in absence of binding to MHC .
15134773	0	CD8	4,7	TCR	67,70	CD8	TCR	925	6962	Gene	Gene	CD8alphaalpha|compound|START_ENTITY homologue|nsubj|CD8alphaalpha homologue|nmod|CD8alphabeta CD8alphabeta|compound|END_ENTITY	The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR co-receptor CD8alphabeta .
15517612	0	CD8	105,108	TCR	110,113	CD8	TCR	925	6962	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
16163672	0	CD8	14,17	TCR	130,133	CD8	TCR	925	6962	Gene	Gene	involvement|nummod|START_ENTITY Assessment|nmod|involvement clone|nsubj|Assessment clone|advcl|using using|dobj|END_ENTITY	Assessment of CD8 involvement in T cell clone avidity by direct measurement of HLA-A2 / Mage3 complex density using a high-affinity TCR like monoclonal antibody .
16188324	0	CD8	122,125	TCR	92,95	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY cognate|dobj|cells present|advcl|cognate present|dobj|END_ENTITY	Idiotypic T cells specific for Morbillivirus nucleocapsid protein process and present their TCR to cognate anti-idiotypic CD8 + T cells .
16210607	0	CD8	64,67	TCR	40,43	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells engagement|compound|END_ENTITY	Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells .
16322475	0	CD8	38,41	TCR	105,108	CD8	TCR	925	6962	Gene	Gene	T-cell|compound|START_ENTITY Fluctuations|nmod|T-cell clonotypes|nsubj|Fluctuations clonotypes|xcomp|demonstrate demonstrate|dobj|flexibility flexibility|nmod|repertoire repertoire|compound|END_ENTITY	Fluctuations of functionally distinct CD8 + T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire .
16385630	0	CD8	106,109	TCR	130,133	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells proliferation|acl|induced induced|nmod|triggering triggering|compound|END_ENTITY	Differential effects of the tryptophan metabolite 3-hydroxyanthranilic_acid on the proliferation of human CD8 + T cells induced by TCR triggering or homeostatic cytokines .
16720899	0	CD8	144,147	TCR	92,95	CD8	TCR	925	328483(Tax:10090)	Gene	Gene	coreceptor|compound|START_ENTITY governed|nmod|coreceptor governed|nsubjpass|Redirection Redirection|nmod|cells cells|acl|delivering delivering|dobj|END_ENTITY	Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression .
16769997	0	CD8	29,32	TCR	57,60	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY size|nmod|cells regulated|nsubjpass|size regulated|nmod|promiscuity promiscuity|compound|END_ENTITY	The clone size of peripheral CD8 T cells is regulated by TCR promiscuity .
1690353	0	CD8	61,64	TCR	39,42	CD8	TCR	925	6962	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
18025165	0	CD8	89,92	TCR	32,35	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|dobj|down-regulation down-regulation|compound|END_ENTITY	Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity .
20139278	0	CD8	56,59	TCR	7,10	CD8	TCR	925	6962	Gene	Gene	CTLs|compound|START_ENTITY use|nmod|CTLs use|nsubj|END_ENTITY	Public TCR use by herpes_simplex_virus-2-specific human CD8 CTLs .
21677135	0	CD8	32,35	TCR	80,83	CD8	TCR	925	6962	Gene	Gene	function|compound|START_ENTITY function|nmod|absence absence|nmod|engagement engagement|compound|END_ENTITY	Anti-CD8 antibodies can trigger CD8 + T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining .
21738624	0	CD8	42,45	TCR	76,79	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY cells|nmod|repertoire repertoire|compound|END_ENTITY	The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotype .
23267020	0	CD8	0,3	TCR	5,8	CD8	TCR	925	6962	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	CD8 + TCR repertoire formation is guided primarily by the peptide component of the antigenic complex .
23791878	0	CD8	69,72	TCR	110,113	CD8	TCR	925	6962	Gene	Gene	START_ENTITY|acl:relcl|possess possess|nsubj|cells cells|acl|modified modified|nmod|transfer transfer|compound|END_ENTITY	Human effector T cells derived from central memory cells rather than CD8 -LRB- + -RRB- T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy .
24552712	0	CD8	120,123	TCR	93,96	CD8	TCR	925	6962	Gene	Gene	T|compound|START_ENTITY downregulation|nmod|T downregulation|nmod|expression expression|compound|END_ENTITY	Myeloid-derived suppressor cells are associated with viral persistence and downregulation of TCR chain expression on CD8 -LRB- + -RRB- T cells in chronic hepatitis_C patients .
25103993	0	CD8	115,118	TCR	30,33	CD8	TCR	925	6962	Gene	Gene	T|compound|START_ENTITY enrichment|nmod|T reveals|dobj|enrichment reveals|nsubj|sequencing sequencing|nmod|repertoires repertoires|compound|END_ENTITY	High-throughput sequencing of TCR repertoires in multiple_sclerosis reveals intrathecal enrichment of EBV-reactive CD8 -LRB- + -RRB- T cells .
25419629	0	CD8	72,75	TCR	4,7	CD8	TCR	925	6962	Gene	Gene	T|compound|START_ENTITY ability|nmod|T dictates|dobj|ability dictates|nsubj|sensitivity sensitivity|nmod:poss|END_ENTITY	The TCR 's sensitivity to self peptide-MHC dictates the ability of naive CD8 -LRB- + -RRB- T cells to respond to foreign antigens .
25427562	0	CD8	59,62	TCR	15,18	CD8	TCR	925	6962	Gene	Gene	coreceptor|compound|START_ENTITY associated|nmod|coreceptor Lck|acl|associated triggered|nmod|Lck triggered|nsubjpass|END_ENTITY	Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor .
25801351	0	CD8	6,9	TCR	50,53	CD8	TCR	925	6962	Gene	Gene	T-cell|compound|START_ENTITY precursors|compound|T-cell display|nsubj|precursors display|dobj|repertoires repertoires|compound|END_ENTITY	Naive CD8 -LRB- + -RRB- T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics .
25911754	0	CD8	0,3	TCR	5,8	CD8	TCR	925	6962	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Bias Bias|compound|END_ENTITY	CD8 + TCR Bias and Immunodominance in HIV-1_Infection .
25945999	0	CD8	24,27	TCR	84,87	CD8	TCR	925	328483(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|Arise Arise|nmod|Because Because|nmod|Selection Selection|compound|END_ENTITY	Human and Murine Clonal CD8 + T Cell Expansions Arise during Tuberculosis Because of TCR Selection .
25945999	0	CD8	24,27	TCR	84,87	CD8	TCR	925	328483(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|Arise Arise|nmod|Because Because|nmod|Selection Selection|compound|END_ENTITY	Human and Murine Clonal CD8 + T Cell Expansions Arise during Tuberculosis Because of TCR Selection .
7768542	0	CD8	32,35	TCR	37,40	CD8	TCR	925	6962	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Spontaneous generation of human CD8 + TCR alpha beta + cells derived from precursors within the double negative compartment .
7901153	0	CD8	97,100	TCR	65,68	CD8	TCR	925	6962	Gene	Gene	line|compound|START_ENTITY activation|nmod|line comodulated|nmod|activation comodulated|nmod|T-cell_antigen_receptor T-cell_antigen_receptor|appos|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
9596673	0	CD8	69,72	TCR	49,52	CD8	TCR	925	6962	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Viral superantigen-induced negative selection of TCR transgenic CD4 + CD8 + thymocytes depends on activation , but not proliferation .
7528767	0	CD8	83,86	TCR-alpha	123,132	CD8	TCR-alpha	925	28755	Gene	Gene	thymocytes|compound|START_ENTITY signaling|nmod|thymocytes receptor|acl|signaling induced|nmod|receptor induced|parataxis|response response|nsubj|synthesis synthesis|nmod|protein protein|amod|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
7528767	0	CD8	83,86	TCR-alpha	200,209	CD8	TCR-alpha	925	28755	Gene	Gene	thymocytes|compound|START_ENTITY signaling|nmod|thymocytes receptor|acl|signaling induced|nmod|receptor induced|parataxis|response response|nmod|signaling signaling|acl:relcl|compensates compensates|nmod|instability instability|amod|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
20380794	0	CD8	40,43	TCR_beta	28,36	CD8	TCR beta	925	21577(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	-LSB- Characteristics of CDR3 of TCR_beta on CD8 + T cells in chronic_hepatitis_B patients -RSB- .
11459831	0	CD8	46,49	TDT	19,22	CD8	TDT	925	1791	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Down-regulation of TDT transcription in CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes by Ikaros proteins in direct competition with an Ets activator .
8642767	0	CD8	186,189	TGF-beta_1	62,72	CD8	TGF-beta 1	925	7040	Gene	Gene	CD3|dep|START_ENTITY level|appos|CD3 level|appos|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
7479952	0	CD8	36,39	TH1	11,14	CD8	TH1	925	51497	Gene	Gene	response|compound|START_ENTITY cytokines|nmod|response cytokines|nsubj|Effects Effects|nmod|END_ENTITY	Effects of TH1 and TH2 cytokines on CD8 + cell response against human_immunodeficiency_virus : implications for long-term survival .
24520422	0	CD8	31,34	TIM-3	15,20	CD8	TIM-3	925	84868	Gene	Gene	cells|compound|START_ENTITY distinguish|nsubj|cells effector|acl:relcl|distinguish Levels|dep|effector Levels|nmod|END_ENTITY	Levels of CD56 + TIM-3 - effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy .
20157599	0	CD8	46,49	TLR2	27,31	CD8	TLR2	925	7097	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|nmod|END_ENTITY	Expression and Function of TLR2 on CD4 Versus CD8 T Cells .
22147891	0	CD8	63,66	TLR3	0,4	CD8	TLR3	925	7098	Gene	Gene	responses|compound|START_ENTITY promotes|dobj|responses promotes|nsubj|END_ENTITY	TLR3 essentially promotes protective class I-restricted memory CD8 T-cell responses to Aspergillus_fumigatus in hematopoietic transplanted patients .
21142450	0	CD8	59,62	TNF-a	34,39	CD8	TNF-a	925	7124	Gene	Gene	lung_injury|compound|START_ENTITY inhibits|dobj|lung_injury inhibits|nsubj|Interference Interference|nmod|signaling signaling|amod|END_ENTITY	Interference with intraepithelial TNF-a signaling inhibits CD8 -LRB- + -RRB- T-cell-mediated lung_injury in influenza_infection .
22230585	0	CD8	81,84	TNF-a	23,28	CD8	TNF-a	925	7124	Gene	Gene	response|compound|START_ENTITY leads|nmod|response leads|nsubj|production production|nmod|END_ENTITY	Impaired production of TNF-a by dendritic cells of older adults leads to a lower CD8 + T cell response against influenza .
23571180	0	CD8	39,42	TNF-a	30,35	CD8	TNF-a	925	7124	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Anti-leukemia T cells in AML : TNF-a CD8 T cells may escape detection and possibly reflect a stage of functional impairment .
24223177	0	CD8	68,71	TNF-a	30,35	CD8	TNF-a	925	21926(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY required|nsubjpass|cells expressed|ccomp|required expressed|nsubj|processing processing|nmod|END_ENTITY	ADAM17-mediated processing of TNF-a expressed by antiviral effector CD8 + T cells is required for severe T-cell-mediated lung_injury .
10361238	0	CD8	0,3	TNF-alpha	66,75	CD8	TNF-alpha	925	7124	Gene	Gene	enhancement|compound|START_ENTITY enhancement|nmod|necrosis necrosis|dep|production production|appos|END_ENTITY	CD8 + T cell-mediated enhancement of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- production and HIV-1 LTR-driven gene expression in human monocytic cells is pertussis toxin-sensitive .
11009092	0	CD8	33,36	TNF-alpha	73,82	CD8	TNF-alpha	925	7124	Gene	Gene	CD4|compound|START_ENTITY CD4|acl|+ +|dobj|thymocytes thymocytes|nmod|END_ENTITY	Sex steroids induce apoptosis of CD8 + CD4 + double-positive thymocytes via TNF-alpha .
15922966	0	CD8	31,34	TNF-alpha	145,154	CD8	TNF-alpha	925	7124	Gene	Gene	cells|compound|START_ENTITY Induction|nmod|cells myeloid|nsubj|Induction myeloid|ccomp|maturated maturated|xcomp|encoding encoding|dobj|END_ENTITY	Induction of leukemia-specific CD8 + cytotoxic T cells with autologous myeloid leukemic cells maturated with a fiber-modified adenovirus encoding TNF-alpha .
16210607	0	CD8	64,67	TNF-alpha	20,29	CD8	TNF-alpha	925	7124	Gene	Gene	cells|compound|START_ENTITY engagement|nmod|cells END_ENTITY|nmod|engagement	Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells .
16596274	0	CD8	67,70	TNF-alpha	33,42	CD8	TNF-alpha	925	7124	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of membrane TNF-alpha on activated peripheral CD8 + T cells in systemic_lupus_erythematosus .
1932375	0	CD8	130,133	TNF-alpha	146,155	CD8	TNF-alpha	925	7124	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	Lymphocytes infiltrating ovarian_malignant_ascites : modulation of IL-2-induced proliferation by IL-4 and of selective increase in CD8 + T cells by TNF-alpha .
8476505	0	CD8	60,63	TNF-alpha	20,29	CD8	TNF-alpha	925	7124	Gene	Gene	clone|compound|START_ENTITY secreted|nmod|clone secreted|nsubj|effect effect|nmod|END_ENTITY	Antiviral effect of TNF-alpha and IFN-gamma secreted from a CD8 + influenza virus-specific CTL clone .
17312109	0	CD8	56,59	TRAIL	82,87	CD8	TRAIL	925	8743	Gene	Gene	cells|compound|START_ENTITY cells|acl:relcl|produce produce|dobj|END_ENTITY	Apoptotic cells induce tolerance by generating helpless CD8 + T cells that produce TRAIL .
21064084	0	CD8	71,74	TRAIL	51,56	CD8	TRAIL	925	8743	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Enhancement of proliferation and downregulation of TRAIL expression on CD8 + T cells by IL-21 .
21621553	0	CD8	40,43	TRAIL	90,95	CD8	TRAIL	925	8743	Gene	Gene	cells|compound|START_ENTITY rescues|dobj|cells rescues|advcl|diminishing diminishing|dobj|susceptibility susceptibility|acl|END_ENTITY	Interleukin-2 rescues helpless effector CD8 + T cells by diminishing the susceptibility to TRAIL mediated death .
22128144	0	CD8	25,28	TRAIL	66,71	CD8	TRAIL	925	8743	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nmod|control control|nmod|expression expression|amod|END_ENTITY	Nab2 regulates secondary CD8 + T-cell responses through control of TRAIL expression .
12964124	0	CD8	89,92	T_cell_receptor	36,51	CD8	T cell receptor	925	6962	Gene	Gene	cytotoxicity|compound|START_ENTITY Relevance|nmod|cytotoxicity Relevance|nmod|END_ENTITY	Relevance of peptide avidity to the T_cell_receptor for cytomegalovirus-specific ex vivo CD8 T cell cytotoxicity .
18342010	0	CD8	54,57	T_cell_receptor	33,48	CD8	T cell receptor	925	6962	Gene	Gene	Restoring|nmod|START_ENTITY Restoring|dobj|association association|nmod|END_ENTITY	Restoring the association of the T_cell_receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes .
19534995	0	CD8	30,33	T_cell_receptor	1,16	CD8	T cell receptor	925	328483(Tax:10090)	Gene	Gene	T|compound|START_ENTITY diversity|nmod|T diversity|compound|END_ENTITY	-LSB- T_cell_receptor diversity of CD8 + T lymphocytes and its association with viral load in individuals with HIV-1_infection -RSB- .
2120773	0	CD8	70,73	T_cell_receptor	14,29	CD8	T cell receptor	925	6962	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
9653085	0	CD8	59,62	T_cell_receptor	10,25	CD8	T cell receptor	925	6962	Gene	Gene	repertoire|nmod|START_ENTITY repertoire|compound|END_ENTITY	Conserved T_cell_receptor repertoire in primary and memory CD8 T cell responses to an acute viral_infection .
2143170	0	CD8	93,96	TcR	40,43	CD8	TcR	925	6962	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Patterns of membrane TcR alpha beta and TcR gamma delta chain expression by normal blood CD4 + CD8 - , CD4-CD8 + , CD4-CD8dim + and CD4-CD8 - lymphocytes .
11167679	0	CD8	49,52	Th1	71,74	CD8	Th1	925	51497	Gene	Gene	T-helper|compound|START_ENTITY T-helper|dep|END_ENTITY	A rapid flow cytometric assay to detect CD4 + and CD8 + T-helper -LRB- Th -RRB- 0 , Th1 and Th2 cells in whole blood and its application to study cytokine levels in atopic_dermatitis before and after cyclosporin therapy .
15925989	0	CD8	83,86	Th1	54,57	CD8	Th1	925	51497	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|loaded loaded|ccomp|elicits elicits|dobj|response response|amod|END_ENTITY	Tumor lysate and IL-18 loaded dendritic cells elicits Th1 response , tumor-specific CD8 + cytotoxic T cells in patients with malignant_glioma .
17576775	0	CD8	0,3	Th1	34,37	CD8	Th1	925	51497	Gene	Gene	START_ENTITY|parataxis|induce induce|dobj|END_ENTITY	CD8 - DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS .
21469104	0	CD8	6,9	Th1	27,30	CD8	Th1	925	51497	Gene	Gene	cells|compound|START_ENTITY drive|nsubj|cells drive|dobj|responses responses|amod|END_ENTITY	Human CD8 T cells drive Th1 responses through the differentiation of TNF/iNOS-producing dendritic cells .
22689880	0	CD8	16,19	Th1	39,42	CD8	Th1	925	51497	Gene	Gene	cells|compound|START_ENTITY cells|acl|producing producing|dobj|polycytokines polycytokines|amod|END_ENTITY	Human antitumor CD8 + T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition .
25202922	0	CD8	151,154	Th1	74,77	CD8	Th1	925	51497	Gene	Gene	Cells|compound|START_ENTITY Homeostasis|nmod|Cells Cytokines/Chemokines|nsubj|Homeostasis Cytokines/Chemokines|dep|Associated Associated|nmod|END_ENTITY	HIV-1 Shedding From the Female Genital Tract is Associated With Increased Th1 Cytokines/Chemokines That Maintain Tissue Homeostasis and Proportions of CD8 + FOXP3 + T Cells .
8260458	0	CD8	113,116	Th1	68,71	CD8	Th1	925	51497	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Function of alpha beta TCR + intestinal intraepithelial lymphocytes : Th1 - and Th2-type cytokine production by CD4 + CD8 - and CD4 + CD8 + T cells for helper activity .
10064055	0	CD8	49,52	Thy-1	26,31	CD8	Thy-1	925	7070	Gene	Gene	+|compound|START_ENTITY antigens|nmod|+ antigens|compound|END_ENTITY	Spontaneous clustering of Thy-1 antigens on CD4 + CD8 + thymocytes lacking TCR engagement by MHC/peptide complexes .
18353298	0	CD8	49,52	Tim-3	4,9	CD8	Tim-3	925	84868	Gene	Gene	cell|compound|START_ENTITY regulates|dobj|cell regulates|nsubj|END_ENTITY	The Tim-3 ligand galectin-9 negatively regulates CD8 + alloreactive T cell and prolongs survival of skin graft .
20679213	0	CD8	33,36	Tim-3	15,20	CD8	Tim-3	925	84868	Gene	Gene	exhaustion|compound|START_ENTITY Cooperation|nmod|exhaustion Cooperation|nmod|END_ENTITY	Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral_infection .
21382414	0	CD8	32,35	Tim-3	23,28	CD8	Tim-3	925	84868	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary_tuberculosis .
21385853	0	CD8	44,47	Tim-3	16,21	CD8	Tim-3	925	84868	Gene	Gene	phenotype|compound|START_ENTITY identifies|dobj|phenotype identifies|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression of Tim-3 and PD-1 identifies a CD8 + T-cell exhaustion phenotype in mice with disseminated acute_myelogenous_leukemia .
21541358	0	CD8	20,23	Tim-3	55,60	CD8	Tim-3	925	84868	Gene	Gene	cells|nummod|START_ENTITY express|nsubj|cells express|dobj|levels levels|nmod|END_ENTITY	HTLV-1 tax specific CD8 + T cells express low levels of Tim-3 in HTLV-1_infection : implications for progression to neurological_complications .
22539292	0	CD8	56,59	Tim-3	12,17	CD8	Tim-3	925	84868	Gene	Gene	response|compound|START_ENTITY restores|dobj|response restores|nsubj|Blockade Blockade|nmod|END_ENTITY	Blockade of Tim-3 signaling restores the virus-specific CD8 T-cell response in patients with chronic hepatitis_B .
22792231	0	CD8	53,56	Tim-3	0,5	CD8	Tim-3	925	84868	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	Tim-3 negatively regulates cytotoxicity in exhausted CD8 + T cells in HIV_infection .
26141233	0	CD8	56,59	Tim-3	103,108	CD8	Tim-3	925	84868	Gene	Gene	responses|compound|START_ENTITY responses|nmod|regulation regulation|nmod|END_ENTITY	IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast_cancer .
19349620	0	CD8	105,108	Toll-like_receptor_4	64,84	CD8	Toll-like receptor 4	925	7099	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like_receptor_4 signaling-dependent CD8 T-cell activation .
15661918	0	CD8	21,24	VCAM-1	0,6	CD8	VCAM-1	925	7412	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ expression|nmod|cells expression|compound|END_ENTITY	VCAM-1 expression on CD8 + cells correlates with enhanced anti-HIV suppressing activity .
20126537	0	CD8	109,112	alpha-melanocyte-stimulating_hormone	17,53	CD8	alpha-melanocyte-stimulating hormone	925	18976(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells involved|nmod|development involved|nsubjpass|END_ENTITY	The neuropeptide alpha-melanocyte-stimulating_hormone is critically involved in the development of cytotoxic CD8 + T cells in mice and humans .
21350948	0	CD8	0,3	androgen_receptor	30,47	CD8	androgen receptor	925	367	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	CD8 + T cells specific for the androgen_receptor are common in patients with prostate_cancer and are able to lyse_prostate_tumor cells .
8228820	0	CD8	85,88	bcl-2	142,147	CD8	bcl-2	925	596	Gene	Gene	onset|nmod|START_ENTITY become|nmod|onset thymocytes|acl|become thymocytes|dep|role role|nmod|END_ENTITY	Immature thymocytes become sensitive to calcium-mediated apoptosis with the onset of CD8 , CD4 , and the T cell receptor expression : a role for bcl-2 ?
9375033	0	CD8	39,42	bcl-2	24,29	CD8	bcl-2	925	596	Gene	Gene	p26|nmod|START_ENTITY p26|amod|END_ENTITY	Decreased expression of bcl-2 -LRB- p26 -RRB- in CD8 -LRB- + -RRB- lymphocytes of patients with T-cell lymphoproliferative_disorders of large granular lymphocytes .
9446659	0	CD8	60,63	bcr-abl	43,50	CD8	bcr-abl	925	25	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Dendritic cells stimulate the expansion of bcr-abl specific CD8 + T cells with cytotoxic activity against leukemic cells from patients with chronic_myeloid_leukemia .
17296789	0	CD8	59,62	cKrox	39,44	CD8	cKrox	925	51043	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation .
18602973	0	CD8	156,159	cKrox	64,69	CD8	cKrox	925	51043	Gene	Gene	+|compound|START_ENTITY commitment|nmod|+ controlling|dobj|commitment factors|acl|controlling expression|appos|factors expression|nmod|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
12208761	0	CD8	79,82	carcinoembryonic_antigen	48,72	CD8	carcinoembryonic antigen	925	111518(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of an interferon-gamma-inducible carcinoembryonic_antigen -LRB- CEA -RRB- CD8 -LRB- + -RRB- T-cell epitope , which mediates tumor killing in CEA transgenic_mice .
12189248	0	CD8	57,60	cutaneous_lymphocyte-associated_antigen	14,53	CD8	cutaneous lymphocyte-associated antigen	925	6404	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression of cutaneous_lymphocyte-associated_antigen by CD8 -LRB- + -RRB- T cells specific for a skin-tropic virus .
11737260	0	CD8	48,51	dipeptidyl-peptidase_IV	14,37	CD8	dipeptidyl-peptidase IV	925	1803	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of dipeptidyl-peptidase_IV -LRB- CD26 -RRB- on CD8 + T cells is significantly decreased in patients with psoriasis_vulgaris and atopic_dermatitis .
10067695	0	CD8	9,12	env	39,42	CD8	env	925	155971(Tax:11676)	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nsubj|response	Enhanced CD8 + T cell response to HIV-1 env by combined immunization with influenza and vaccinia_virus recombinants .
17566017	0	CD8	53,56	eomesodermin	31,43	CD8	eomesodermin	925	8320	Gene	Gene	activity|nummod|START_ENTITY controls|dobj|activity controls|nsubj|END_ENTITY	The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal_cancer .
18523274	0	CD8	56,59	eomesodermin	131,143	CD8	eomesodermin	925	8320	Gene	Gene	response|compound|START_ENTITY facilitates|dobj|response facilitates|nmod|expression expression|nmod|molecules molecules|dep|END_ENTITY	Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules -LRB- eomesodermin and its targets : perforin and granzyme_B -RRB- .
25100841	0	CD8	41,44	eomesodermin	5,17	CD8	eomesodermin	925	8320	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
25100841	0	CD8	67,70	eomesodermin	5,17	CD8	eomesodermin	925	8320	Gene	Gene	subset|compound|START_ENTITY identifies|dobj|subset identifies|nsubj|expression expression|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
10677522	0	CD8	65,68	fas_ligand	22,32	CD8	fas ligand	925	356	Gene	Gene	+|compound|START_ENTITY regulation|nmod|+ functions|nmod|regulation functions|nmod|END_ENTITY	The dual functions of fas_ligand in the regulation of peripheral CD8 + and CD4 + T cells .
23874581	0	CD8	86,89	foxp3	147,152	CD8	foxp3	925	20371(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY controls|nmod|induction controls|nmod|frequency frequency|nmod|ICOS ICOS|compound|END_ENTITY	Mesothelin virus-like particle immunization controls pancreatic_cancer growth through CD8 + T cell induction and reduction in the frequency of CD4 + foxp3 + ICOS - regulatory T cells .
11861840	0	CD8	19,22	gag	81,84	CD8	gag	925	155030(Tax:11676)	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	High-level primary CD8 -LRB- + -RRB- T-cell response to human_immunodeficiency_virus_type_1 gag and env generated by vaccination with recombinant_vesicular_stomatitis viruses .
16652028	0	CD8	38,41	gag	70,73	CD8	gag	925	155030(Tax:11676)	Gene	Gene	T-cells|compound|START_ENTITY cross-stimulation|nmod|T-cells cross-stimulation|nmod|protein protein|compound|END_ENTITY	Dominant ex vivo cross-stimulation of CD8 + T-cells with whole soluble gag protein in HIV-infected subjects .
24227853	0	CD8	123,126	gag	56,59	CD8	gag	925	17276(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY results|nmod|responses construct|dobj|results construct|nsubj|Vaccination Vaccination|nmod|protein protein|acl:relcl|introduces introduces|dobj|antigen antigen|compound|END_ENTITY	Vaccination with a fusion protein that introduces HIV-1 gag antigen into a multitrimer CD40L construct results in enhanced CD8 + T cell responses and protection from viral challenge by vaccinia-gag .
19011158	0	CD8	66,69	gamma_chain	14,25	CD8	gamma chain	925	3561	Gene	Gene	+|compound|START_ENTITY regulate|dobj|+ regulate|nsubj|cytokines cytokines|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
10473580	0	CD8	65,68	gp180	76,81	CD8	gp180	925	5788	Gene	Gene	molecule|nmod|START_ENTITY class|acl:relcl|molecule ligand|nsubj|class ligand|dobj|END_ENTITY	The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells .
11890713	0	CD8	78,81	gp180	62,67	CD8	gp180	925	5788	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|glycoprotein glycoprotein|appos|END_ENTITY	A non-class I MHC intestinal epithelial surface glycoprotein , gp180 , binds to CD8 .
9329971	0	CD8	39,42	gp180	24,29	CD8	gp180	925	5788	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Defective expression of gp180 , a novel CD8 ligand on intestinal epithelial cells , in inflammatory_bowel_disease .
20357255	0	CD8	76,79	granulocyte-macrophage_colony-stimulating_factor	14,62	CD8	granulocyte-macrophage colony-stimulating factor	925	1437	Gene	Gene	factor|compound|START_ENTITY factor|nsubj|END_ENTITY	Cutting edge : granulocyte-macrophage_colony-stimulating_factor is the major CD8 + T cell-derived licensing factor for dendritic cell activation .
19687290	0	CD8	27,30	granulysin	13,23	CD8	granulysin	925	10578	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Induction of granulysin in CD8 + T cells by IL-21 and IL-15 is suppressed by human_immunodeficiency_virus-1 .
10449281	0	CD8	74,77	granzyme_A	34,44	CD8	granzyme A	925	3001	Gene	Gene	present|compound|START_ENTITY granules|nmod|present co-expressed|nmod|granules co-expressed|nmod|END_ENTITY	Perforin is not co-expressed with granzyme_A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic_HIV_infection .
19646207	0	CD8	15,18	granzyme_A	41,51	CD8	granzyme A	925	3001	Gene	Gene	Recruitment|nmod|START_ENTITY T|nsubj|Recruitment T|ccomp|associated associated|nsubjpass|cells cells|acl|expressing expressing|dobj|END_ENTITY	Recruitment of CD8 -LRB- + -RRB- T cells expressing granzyme_A is associated with lesion progression in human cutaneous_leishmaniasis .
26519105	0	CD8	137,140	granzyme_A	97,107	CD8	granzyme A	925	3001	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme_A expression by virus-specific CD8 -LRB- + -RRB- T cells .
15356127	0	CD8	67,70	granzyme_B	15,25	CD8	granzyme B	925	3002	Gene	Gene	homeostasis|compound|START_ENTITY inhibitor|nmod|homeostasis protease|dobj|inhibitor protease|nsubj|role role|nmod|serine serine|amod|END_ENTITY	A role for the granzyme_B inhibitor serine protease inhibitor 6 in CD8 + memory cell homeostasis .
15875183	0	CD8	42,45	granzyme_B	20,30	CD8	granzyme B	925	3002	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Decreased number of granzyme_B + activated CD8 + cytotoxic T lymphocytes in the inflammatory background of HIV-associated_Hodgkin 's _ lymphoma .
16547231	0	CD8	65,68	granzyme_B	107,117	CD8	granzyme B	925	3002	Gene	Gene	T|compound|START_ENTITY stimulation|nmod|T concurrent|nmod|stimulation lymphocytes|amod|concurrent death|dep|lymphocytes death|dep|role role|nmod|END_ENTITY	Apoptotic death concurrent with CD3 stimulation in primary human CD8 + T lymphocytes : a role for endogenous granzyme_B .
17125145	0	CD8	48,51	granzyme_B	14,24	CD8	granzyme B	925	3002	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Bcl6 controls granzyme_B expression in effector CD8 + T cells .
19616200	0	CD8	15,18	granzyme_B	61,71	CD8	granzyme B	925	3002	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
22430249	0	CD8	36,39	granzyme_B	57,67	CD8	granzyme B	925	3002	Gene	Gene	T|compound|START_ENTITY IL-21|nmod|T cells|amod|IL-21 induction|nmod|cells induces|nsubj|induction induces|dobj|END_ENTITY	IL-27 induction of IL-21 from human CD8 + T cells induces granzyme_B in an autocrine manner .
23421932	0	CD8	20,23	granzyme_B	43,53	CD8	granzyme B	925	3002	Gene	Gene	+|compound|START_ENTITY role|nmod|+ END_ENTITY|nsubj|role	A possible role for CD8 + and non-CD8 + cell granzyme_B in early small airway wall remodelling in centrilobular_emphysema .
9640249	0	CD8	4,7	granzyme_B	9,19	CD8	granzyme B	925	3002	Gene	Gene	+|nummod|START_ENTITY END_ENTITY|nmod:npmod|+	The CD8 + granzyme_B + T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells .
8976172	0	CD8	35,38	insulin	8,15	CD8	insulin	925	3630	Gene	Gene	cells|compound|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent_diabetes .
11167992	0	CD8	143,146	interferon-gamma	100,116	CD8	interferon-gamma	925	3458	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	Patients with inflammatory_bowel_disease -LRB- IBD -RRB- reveal increased induction capacity of intracellular interferon-gamma -LRB- IFN-gamma -RRB- in peripheral CD8 + lymphocytes co-cultured with intestinal epithelial cells .
11380612	0	CD8	10,13	interferon-gamma	99,115	CD8	interferon-gamma	925	15978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells cells|acl|producing producing|dobj|levels levels|nmod|END_ENTITY	Epidermal CD8 + T cells in chronic plaque_psoriasis are Tc1 cells producing heterogeneous levels of interferon-gamma .
11972627	0	CD8	87,90	interferon-gamma	67,83	CD8	interferon-gamma	925	3458	Gene	Gene	+|compound|START_ENTITY enhance|nmod|+ enhance|dobj|production production|nmod|END_ENTITY	Products from human mast cell line cells enhance the production of interferon-gamma by CD8 + and CD4 + T cells .
12828563	0	CD8	110,113	interferon-gamma	39,55	CD8	interferon-gamma	925	3458	Gene	Gene	cells|compound|START_ENTITY necrosis|dobj|cells necrosis|nsubj|signalling signalling|nmod|END_ENTITY	Aberrant T-cell receptor signalling of interferon-gamma - and tumour necrosis factor-alpha-producing cytotoxic CD8 + Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia .
1330577	0	CD8	88,91	interferon-gamma	38,54	CD8	interferon-gamma	925	3458	Gene	Gene	cells|amod|START_ENTITY induces|nmod|cells induces|dobj|secretion secretion|amod|END_ENTITY	The viral superantigen Mls-1a induces interferon-gamma secretion by specifically primed CD8 + cells but fails to trigger cytotoxicity .
15059848	0	CD8	70,73	interferon-gamma	100,116	CD8	interferon-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY subset|nmod|T mediated|nmod|subset cells|amod|mediated cells|acl|producing producing|dobj|END_ENTITY	HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8 -LRB- + -RRB- T cells producing both interferon-gamma and tumor_necrosis_factor-alpha .
17589293	0	CD8	63,66	interferon-gamma	113,129	CD8	interferon-gamma	925	3458	Gene	Gene	cells|nummod|START_ENTITY fail|nsubj|cells fail|xcomp|control control|nmod|production production|amod|END_ENTITY	Human_papillomavirus_16 E6-specific CD45RA + CCR7 + high avidity CD8 + T cells fail to control tumor growth despite interferon-gamma production in patients with cervical_cancer .
1902247	0	CD8	144,147	interferon-gamma	65,81	CD8	interferon-gamma	925	3458	Gene	Gene	protein|compound|START_ENTITY levels|nmod|protein levels|nmod|receptors receptors|compound|END_ENTITY	Immune cell activation in melioidosis : increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein .
19100424	0	CD8	31,34	interferon-gamma	60,76	CD8	interferon-gamma	925	3458	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|display display|dobj|impairment impairment|amod|END_ENTITY	Human_cytomegalovirus specific CD8 -LRB- + -RRB- T lymphocytes display interferon-gamma secretion impairment in kidney transplant recipients with pp65 antigenemia .
7769110	0	CD8	50,53	interferon-gamma	78,94	CD8	interferon-gamma	925	3458	Gene	Gene	responses|nmod|START_ENTITY Inhibition|nmod|responses +|nsubj|Inhibition +|ccomp|mediated mediated|nmod|END_ENTITY	Inhibition of T cell responses by activated human CD8 + T cells is mediated by interferon-gamma and is defective in chronic_progressive_multiple_sclerosis .
8611751	0	CD8	25,28	interferon-gamma	65,81	CD8	interferon-gamma	925	3458	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|clone clone|acl:relcl|inhibits inhibits|dobj|production production|amod|END_ENTITY	Alpha s1-casein-specific CD8 + T cell clone that inhibits its own interferon-gamma production by producing interleukin-10 .
9255980	0	CD8	99,102	interferon-gamma	54,70	CD8	interferon-gamma	925	3458	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Enhancing effect of interleukin-4 on the secretion of interferon-gamma by alpha s1-casein-specific CD8 + T cells .
9472663	0	CD8	18,21	interferon-gamma	151,167	CD8	interferon-gamma	925	3458	Gene	Gene	lymphocytes|nummod|START_ENTITY defect|nmod|lymphocytes defect|dep|abnormalities abnormalities|nmod|production production|nmod|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9472663	0	CD8	228,231	interferon-gamma	151,167	CD8	interferon-gamma	925	3458	Gene	Gene	+|compound|START_ENTITY defect|dep|+ defect|dep|abnormalities abnormalities|nmod|production production|nmod|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
2522938	0	CD8	85,88	interferon_gamma	39,55	CD8	interferon gamma	925	3458	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|compound|END_ENTITY	Prostaglandin_E2 selectively increases interferon_gamma receptor expression on human CD8 + lymphocytes .
10334386	0	CD8	41,44	interleukin-10	14,28	CD8	interleukin-10	925	3586	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of interleukin-10 in isolated CD8 + T cells and monocytes from growth factor-mobilized peripheral blood stem cell products : a mechanism of immune_dysfunction .
10733741	0	CD8	8,11	interleukin-10	35,49	CD8	interleukin-10	925	3586	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|secretion secretion|amod|END_ENTITY	Role of CD8 + T cells in endogenous interleukin-10 secretion associated with visceral_leishmaniasis .
12581488	0	CD8	75,78	interleukin-10	22,36	CD8	interleukin-10	925	3586	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	IFN-alpha2b increases interleukin-10 expression in primary activated human CD8 + T cells .
7890312	0	CD8	81,84	interleukin-10	10,24	CD8	interleukin-10	925	3586	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts .
8611751	0	CD8	25,28	interleukin-10	106,120	CD8	interleukin-10	925	3586	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|dobj|clone clone|acl:relcl|inhibits inhibits|advcl|producing producing|xcomp|END_ENTITY	Alpha s1-casein-specific CD8 + T cell clone that inhibits its own interferon-gamma production by producing interleukin-10 .
9105428	0	CD8	142,145	interleukin-10	69,83	CD8	interleukin-10	925	3586	Gene	Gene	subpopulation|compound|START_ENTITY expressed|nmod|subpopulation promoted|advcl|expressed promoted|advcl|END_ENTITY	Autoantibody production in healthy elderly people is not promoted by interleukin-10 although this cytokine is expressed in them by a peculiar CD8 + CD3 + large granular cell subpopulation .
19333920	0	CD8	9,12	interleukin-13	87,101	CD8	interleukin-13	925	3596	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|levels levels|nmod|END_ENTITY	Effector CD8 + T cells in systemic_sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis .
19578849	0	CD8	102,105	interleukin-15	43,57	CD8	interleukin-15	925	3600	Gene	Gene	T|compound|START_ENTITY expansion|nmod|T END_ENTITY|nmod|expansion	Differential effects of interleukin-12 and interleukin-15 on expansion of NK_cell_receptor-expressing CD8 + T cells .
24681356	0	CD8	31,34	interleukin-17	13,27	CD8	interleukin-17	925	3605	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Secretion of interleukin-17 by CD8 + T cells expressing CD146 -LRB- MCAM -RRB- .
12871213	0	CD8	0,3	interleukin-18	126,140	CD8	interleukin-18	925	3606	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|activate activate|xcomp|secrete secrete|xcomp|END_ENTITY	CD8 + immunoregulatory cells in the graft-versus-host reaction : CD8 T cells activate dendritic cells to secrete interleukin-12 / interleukin-18 and induce T helper 1 autoantibody .
12871213	0	CD8	63,66	interleukin-18	126,140	CD8	interleukin-18	925	3606	Gene	Gene	cells|compound|START_ENTITY activate|nsubj|cells activate|xcomp|secrete secrete|xcomp|END_ENTITY	CD8 + immunoregulatory cells in the graft-versus-host reaction : CD8 T cells activate dendritic cells to secrete interleukin-12 / interleukin-18 and induce T helper 1 autoantibody .
9849583	0	CD8	27,30	interleukin-18	59,73	CD8	interleukin-18	925	3606	Gene	Gene	T|compound|START_ENTITY activation|nmod|T lymphocytes|nsubj|activation lymphocytes|advcl|END_ENTITY	Direct activation of human CD8 + cytotoxic T lymphocytes by interleukin-18 .
10561318	0	CD8	44,47	interleukin-2	114,127	CD8	interleukin-2	925	3558	Gene	Gene	tumor-infiltrating|compound|START_ENTITY trial|nmod|tumor-infiltrating lymphocytes|nsubj|trial lymphocytes|nmod|END_ENTITY	Multicenter , randomized , phase III trial of CD8 -LRB- + -RRB- tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal_cell_carcinoma .
11477316	0	CD8	131,134	interleukin-2	82,95	CD8	interleukin-2	925	3558	Gene	Gene	using|nmod|START_ENTITY using|dobj|analysis analysis|nmod|inhibition inhibition|compound|END_ENTITY	Quantitation of immunosuppression by tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8 -LRB- - -RRB- and CD8 -LRB- + -RRB- peripheral blood T cells .
1533853	0	CD8	45,48	interleukin-2	61,74	CD8	interleukin-2	925	3558	Gene	Gene	+|compound|START_ENTITY receptors|nmod|+ Modulation|nmod|receptors T|nsubj|Modulation T|nmod|END_ENTITY	Modulation of histamine type II receptors on CD8 + T cells by interleukin-2 and cimetidine .
1900952	0	CD8	18,21	interleukin-2	78,91	CD8	interleukin-2	925	3558	Gene	Gene	cell|compound|START_ENTITY anergy|nmod|cell anergy|dep|cytolysis cytolysis|nmod|absence absence|nmod|production production|compound|END_ENTITY	Split anergy in a CD8 + T cell : receptor-dependent cytolysis in the absence of interleukin-2 production .
1902247	0	CD8	144,147	interleukin-2	94,107	CD8	interleukin-2	925	3558	Gene	Gene	protein|compound|START_ENTITY levels|nmod|protein levels|nmod|receptors receptors|compound|END_ENTITY	Immune cell activation in melioidosis : increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein .
20795538	0	CD8	36,39	interleukin-2	12,25	CD8	interleukin-2	925	3558	Gene	Gene	differentiation|nummod|START_ENTITY role|nmod|differentiation role|nmod|END_ENTITY	The role of interleukin-2 in memory CD8 cell differentiation .
21594368	0	CD8	35,38	interleukin-2	85,98	CD8	interleukin-2	925	3558	Gene	Gene	+|compound|START_ENTITY circulating|dobj|+ expansion|acl|circulating lymphocytes|nsubj|expansion lymphocytes|nmod|immunotherapy immunotherapy|nmod|END_ENTITY	Selective expansion of circulating CD8 + lymphocytes during cancer immunotherapy with interleukin-2 plus alpha-interferon but not with interleukin-2 alone .
24887424	0	CD8	112,115	interleukin-2	95,108	CD8	interleukin-2	925	3558	Gene	Gene	T-cells|compound|START_ENTITY END_ENTITY|nmod|T-cells	Rejection quantity in kidney transplant recipients is associated with increasing intracellular interleukin-2 in CD8 + T-cells .
7890312	0	CD8	81,84	interleukin-2	57,70	CD8	interleukin-2	925	3558	Gene	Gene	T|compound|START_ENTITY T|amod|interleukin-10 interleukin-10|nmod|activities activities|nmod|END_ENTITY	Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts .
8556489	0	CD8	83,86	interleukin-2	103,116	CD8	interleukin-2	925	3558	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ responsiveness|nmod|lymphocytes deoxythymidine|nmod|responsiveness deoxythymidine|nmod|END_ENTITY	Inhibitory effect of 3 ' - azido-3 ' - deoxythymidine on proliferative responsiveness of CD8 + lymphocytes to interleukin-2 .
20454646	0	CD8	37,40	interleukin-27	19,33	CD8	interleukin-27	925	246778	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	A pivotal role for interleukin-27 in CD8 + T cell functions and generation of cytotoxic T lymphocytes .
15730392	0	CD8	125,128	interleukin-3	77,90	CD8	interleukin-3	925	3562	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Mature dendritic cells differentiated in the presence of interferon-beta and interleukin-3 prime functional antigen-specific CD8 T cells .
16133111	0	CD8	86,89	interleukin-3	44,57	CD8	interleukin-3	925	3562	Gene	Gene	responses|nummod|START_ENTITY induces|dobj|responses induces|nsubj|vaccine vaccine|acl|generated generated|nmod|END_ENTITY	A new dendritic cell vaccine generated with interleukin-3 and interferon-beta induces CD8 + T cell responses against NA17-A2 tumor peptide in melanoma patients .
11014649	0	CD8	154,157	interleukin-4	11,24	CD8	interleukin-4	925	3565	Gene	Gene	cells|compound|START_ENTITY absence|nmod|cells transplant_arteriosclerosis|nmod|absence development|nmod|transplant_arteriosclerosis trigger|dobj|development trigger|nsubj|expression expression|compound|END_ENTITY	Intragraft interleukin-4 mRNA expression after short-term CD154 blockade may trigger delayed development of transplant_arteriosclerosis in the absence of CD8 + T cells .
11141321	0	CD8	56,59	interleukin-4	13,26	CD8	interleukin-4	925	3565	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Decreases in interleukin-4 secretion by invariant CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple_sclerosis .
17907151	0	CD8	16,19	interleukin-4	60,73	CD8	interleukin-4	925	3565	Gene	Gene	Presence|nmod|START_ENTITY +|nsubj|Presence +|nmod|potential potential|amod|END_ENTITY	Presence of CD4 + CD8 + double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic_sclerosis .
9255980	0	CD8	99,102	interleukin-4	20,33	CD8	interleukin-4	925	3565	Gene	Gene	T|compound|START_ENTITY interferon-gamma|nmod|T cells|amod|interferon-gamma secretion|nmod|cells END_ENTITY|nmod|secretion	Enhancing effect of interleukin-4 on the secretion of interferon-gamma by alpha s1-casein-specific CD8 + T cells .
22529903	0	CD8	62,65	interleukin-7	40,53	CD8	interleukin-7	925	3574	Gene	Gene	growth|compound|START_ENTITY growth|amod|END_ENTITY	Exogenous amino_acids are essential for interleukin-7 induced CD8 T cell growth .
16537621	0	CD8	79,82	interleukin-7_receptor_alpha_chain	18,52	CD8	interleukin-7 receptor alpha chain	925	16197(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of the interleukin-7_receptor_alpha_chain -LRB- CD127 -RRB- on virus-specific CD8 + T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis_B_virus infection .
19616200	0	CD8	15,18	interleukin_17	86,100	CD8	interleukin 17	925	3605	Gene	Gene	cells|compound|START_ENTITY cells|nsubj|cells expressed|dep|cells expressed|nsubj|granzyme_B granzyme_B|appos|Foxp3 Foxp3|appos|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
15879103	0	CD8	76,79	killer_cell_lectin-like_receptor_G1	14,49	CD8	killer cell lectin-like receptor G1	925	10219	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	Expression of killer_cell_lectin-like_receptor_G1 on antigen-specific human CD8 + T lymphocytes during active , latent , and resolved_infection and its relation with CD57 .
23325888	0	CD8	86,89	killer_cell_lectin-like_receptor_G1	34,69	CD8	killer cell lectin-like receptor G1	925	10219	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	Id2 influences differentiation of killer_cell_lectin-like_receptor_G1 -LRB- hi -RRB- short-lived CD8 + effector T cells .
1683650	0	CD8	70,73	lactotransferrin	30,46	CD8	lactotransferrin	925	17002(Tax:10090)	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Immunostimulatory activity of lactotransferrin and maturation of CD4 - CD8 - murine thymocytes .
10545478	0	CD8	76,79	lymphocyte_activation_gene-3	24,52	CD8	lymphocyte activation gene-3	925	3902	Gene	Gene	molecules|compound|START_ENTITY co-distributed|nmod|molecules co-distributed|nsubjpass|II II|amod|END_ENTITY	The MHC class II ligand lymphocyte_activation_gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes .
27053622	0	CD8	73,76	lymphocyte_activation_gene-3	24,52	CD8	lymphocyte activation gene-3	925	3902	Gene	Gene	T|compound|START_ENTITY T|amod|END_ENTITY	-LSB- Elevated expression of lymphocyte_activation_gene-3 on peripheral blood CD8 -LRB- + -RRB- T lymphocytes in patients with chronic hepatitis_B_virus infection -RSB- .
7673707	0	CD8	70,73	lymphocyte_chemoattractant_factor	31,64	CD8	lymphocyte chemoattractant factor	925	3603	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Histamine-induced secretion of lymphocyte_chemoattractant_factor from CD8 + T cells is independent of transcription and translation .
8598478	0	CD8	81,84	lymphocyte_chemoattractant_factor	20,53	CD8	lymphocyte chemoattractant factor	925	3603	Gene	Gene	cells|compound|START_ENTITY Secretion|nmod|cells Secretion|appos|END_ENTITY	Secretion of IL-16 -LRB- lymphocyte_chemoattractant_factor -RRB- from serotonin-stimulated CD8 + T cells in vitro .
7535702	0	CD8	0,3	macrophage_inflammatory_protein_1_alpha	74,113	CD8	macrophage inflammatory protein 1 alpha	925	6348	Gene	Gene	+|compound|START_ENTITY sources|nsubj|+ sources|nmod|END_ENTITY	CD8 + and CD45RA + human peripheral blood lymphocytes are potent sources of macrophage_inflammatory_protein_1_alpha , interleukin-8 and RANTES .
15529349	0	CD8	13,16	major_histocompatibility_complex_class_I_chain-related_gene_A	45,106	CD8	major histocompatibility complex class I chain-related gene A	925	100507436	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	Autoreactive CD8 + cytotoxic T lymphocytes to major_histocompatibility_complex_class_I_chain-related_gene_A in patients with Beh et 's disease .
24372339	0	CD8	104,107	matrix_metalloproteinases	25,50	CD8	matrix metalloproteinases	925	4314	Gene	Gene	relationship|dep|START_ENTITY relationship|nmod|END_ENTITY	The relationship between matrix_metalloproteinases -LRB- MMP-3 , _ -8 , _ -9 -RRB- in serum and peripheral lymphocytes -LRB- CD8 -LRB- + -RRB- , CD56 -LRB- + -RRB- -RRB- in Down_syndrome children with gingivitis .
25347474	0	CD8	21,24	miR-23a	10,17	CD8	miR-23a	925	407010	Gene	Gene	lymphocytes|nummod|START_ENTITY END_ENTITY|nmod|lymphocytes	Targeting miR-23a in CD8 + cytotoxic T lymphocytes prevents tumor-dependent immunosuppression .
18373244	0	CD8	22,25	mucin	53,58	CD8	mucin	925	100508689	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Quantification of the CD8 + T cell response against a mucin epitope in patients with breast_cancer .
9510211	0	CD8	96,99	myelin_basic_protein	58,78	CD8	myelin basic protein	925	4155	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|amod|END_ENTITY	MHC class I-restricted lysis of human oligodendrocytes by myelin_basic_protein peptide-specific CD8 T lymphocytes .
20577877	0	CD8	0,3	p53	58,61	CD8	p53	925	7157	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	CD8 + T cell recognition of polymorphic wild-type sequence p53 -LRB- 65-73 -RRB- peptides in squamous_cell_carcinoma of the head_and_neck .
8630734	0	CD8	43,46	p56lck	128,134	CD8	p56lck	925	3932	Gene	Gene	thymocytes|compound|START_ENTITY impaired|nmod|thymocytes impaired|nmod|consequence consequence|acl:relcl|diminish diminish|dobj|END_ENTITY	TCR activation of ZAP70 is impaired in CD4 + CD8 + thymocytes as a consequence of intrathymic interactions that diminish available p56lck .
1691263	0	CD8	90,93	pore-forming_protein	27,47	CD8	pore-forming protein	925	5551	Gene	Gene	+|compound|START_ENTITY expression|nmod|+ expression|amod|END_ENTITY	Interleukin_2 induction of pore-forming_protein gene expression in human peripheral blood CD8 + T cells .
18853954	0	CD8	54,57	pp65	49,53	CD8	pp65	925	18826(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Polyfunctional cytomegalovirus-specific CD4 + and pp65 CD8 + T cells protect against high-level replication after liver transplantation .
18311511	0	CD8	6,9	preproinsulin	51,64	CD8	preproinsulin	925	3630	Gene	Gene	responses|compound|START_ENTITY responses|nmod|epitope epitope|acl|set set|nmod|END_ENTITY	Human CD8 responses to a complete epitope set from preproinsulin : implications for approaches to epitope discovery .
22522618	0	CD8	50,53	preproinsulin	12,25	CD8	preproinsulin	925	3630	Gene	Gene	cells|compound|START_ENTITY restricted|nsubj|cells signal|acl:relcl|restricted signal|compound|END_ENTITY	Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill b-cells .
22943201	0	CD8	0,3	preproinsulin	29,42	CD8	preproinsulin	925	3630	Gene	Gene	autoreactivity|compound|START_ENTITY autoreactivity|nmod|END_ENTITY	CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity .
12080079	0	CD8	133,136	procaspase-3	97,109	CD8	procaspase-3	925	836	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Selective inhibition of dipeptidyl_peptidase_I , not caspases , prevents the partial processing of procaspase-3 in CD3-activated human CD8 -LRB- + -RRB- T lymphocytes .
18455515	0	CD8	56,59	programmed_death_1	8,26	CD8	programmed death 1	925	5133	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Dynamic programmed_death_1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis_B .
16458609	0	CD8	20,23	prostate-specific_antigen	46,71	CD8	prostate-specific antigen	925	354	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Correlation between CD8 + T cells specific for prostate-specific_antigen and level of disease in patients with prostate_cancer .
15048720	0	CD8	38,41	prostein	63,71	CD8	prostein	925	85414	Gene	Gene	cell|compound|START_ENTITY Identification|nmod|cell epitopes|nsubj|Identification epitopes|nmod|END_ENTITY	Identification of naturally processed CD8 T cell epitopes from prostein , a prostate tissue-specific vaccine candidate .
8642767	0	CD8	186,189	transforming_growth_factor-beta_1	27,60	CD8	transforming growth factor-beta 1	925	7040	Gene	Gene	CD3|dep|START_ENTITY level|appos|CD3 level|amod|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
8666832	0	CD8	46,49	tumor_necrosis_factor_alpha	75,102	CD8	tumor necrosis factor alpha	925	7124	Gene	Gene	T|compound|START_ENTITY Detection|nmod|T lymphocytes|nsubj|Detection lymphocytes|dobj|END_ENTITY	Detection and quantification of blood-derived CD8 + T lymphocytes secreting tumor_necrosis_factor_alpha in response to HLA-A2 .1 - binding melanoma and viral peptide antigens .
10233753	0	CD80	21,25	B7-1	15,19	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Enhancement of B7-1 -LRB- CD80 -RRB- expression on B-lymphoma cells by irradiation .
10393529	0	CD80	50,54	B7-1	56,60	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel stimulus , oncogene , induces expression of CD80 -LRB- B7-1 -RRB- gene .
10528182	0	CD80	32,36	B7-1	26,30	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Mutual regulation between B7-1 -LRB- CD80 -RRB- expressed on T cells and IL-4 .
11342441	0	CD80	21,25	B7-1	15,19	CD80	B7-1	941	941	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Targeting of a B7-1 -LRB- CD80 -RRB- immunoglobulin G fusion protein to acute_myeloid_leukemia blasts increases their costimulatory activity for autologous remission T cells .
11459169	0	CD80	0,4	B7-1	6,10	CD80	B7-1	941	941	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD80 -LRB- B7-1 -RRB- expression on human acute myeloid leukaemic cells cultured with GM-CSF , _ IL-3 and IL-6 .
11698282	0	CD80	121,125	B7-1	127,131	CD80	B7-1	941	941	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dendritic cells from patients with myeloma are numerically normal but functionally defective as they fail to up-regulate CD80 -LRB- B7-1 -RRB- expression after huCD40LT stimulation because of inhibition by transforming_growth_factor-beta1 and interleukin-10 .
11956426	0	CD80	25,29	B7-1	19,23	CD80	B7-1	941	941	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phase I trial of a B7-1 -LRB- CD80 -RRB- gene modified autologous_tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic_renal_cell_carcinoma .
12100477	0	CD80	65,69	B7-1	71,75	CD80	B7-1	941	941	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Expansion of CD5 - B cells in multiple_sclerosis correlates with CD80 -LRB- B7-1 -RRB- expression .
12860928	0	CD80	41,45	B7-1	36,40	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	BCL6 controls the expression of the B7-1 / CD80 costimulatory receptor in germinal center B cells .
16489051	0	CD80	32,36	B7-1	26,30	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Low surface expression of B7-1 -LRB- CD80 -RRB- is an immunoescape mechanism of colon_carcinoma .
8552995	0	CD80	50,54	B7-1	44,48	CD80	B7-1	941	941	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Lipopolysaccharide effectively up-regulates B7-1 -LRB- CD80 -RRB- expression and costimulatory function of human monocytes .
8603815	0	CD80	54,58	B7-1	48,52	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Vaccination of tumor cells transfected with the B7-1 -LRB- CD80 -RRB- gene induces the anti-metastatic effect and tumor immunity in mice .
9144510	0	CD80	79,83	B7-1	85,89	CD80	B7-1	12519(Tax:10090)	941	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 -LRB- B7-1 -RRB- but not CD86 -LRB- B7-2 -RRB- on murine fibroblasts .
9233610	0	CD80	38,42	B7-1	32,36	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of donor and recipient B7-1 -LRB- CD80 -RRB- in allograft rejection .
9533442	0	CD80	67,71	B7-1	73,77	CD80	B7-1	12519(Tax:10090)	12519(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Regulation of T cell autoreactivity to MHC class II by controlling CD80 -LRB- B7-1 -RRB- expression on B cells .
9846836	0	CD80	6,10	B7-2	13,17	CD80	B7-2	941	942	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	B7-1 -LRB- CD80 -RRB- , B7-2 -LRB- CD86 -RRB- , interleukin-12 and transforming_growth_factor-beta mRNA expression in CSF and peripheral blood mononuclear cells from multiple_sclerosis patients .
16818658	0	CD80	0,4	CD11b	70,75	CD80	CD11b	12519(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	CD80 in immune suppression by mouse ovarian_carcinoma-associated Gr-1 + CD11b + myeloid cells .
12355442	0	CD80	60,64	CD25	78,82	CD80	CD25	941	3559	Gene	Gene	START_ENTITY|dobj|cells cells|nummod|+ +|compound|END_ENTITY	Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25 + regulatory T cells .
10502560	0	CD80	30,34	CD28	0,4	CD80	CD28	12519(Tax:10090)	12487(Tax:10090)	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	CD28 interactions with either CD80 or CD86 are sufficient to induce allergic_airway_inflammation in mice .
10600000	0	CD80	42,46	CD28	54,58	CD80	CD28	941	940	Gene	Gene	CD86|nummod|START_ENTITY CD86|nummod|END_ENTITY	Expression of the costimulator molecules , CD80 , CD86 , CD28 , and CD152 on lymphocytes from neonates and young children .
14975355	0	CD80	39,43	CD28	51,55	CD80	CD28	941	940	Gene	Gene	START_ENTITY|dep|CD152 CD152|compound|END_ENTITY	Expression of costimulatory molecules -LRB- CD80 , CD86 , CD28 , CD152 -RRB- , accessory molecules -LRB- TCR alphabeta , TCR gammadelta -RRB- and T cell lineage molecules -LRB- CD4 + , CD8 + -RRB- in PBMC of leprosy patients using Mycobacterium_leprae antigen -LRB- MLCWA -RRB- with murabutide and T cell peptide of Trat protein .
15467723	0	CD80	62,66	CD28	0,4	CD80	CD28	12519(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86 .
16339518	0	CD80	0,4	CD28	49,53	CD80	CD28	12519(Tax:10090)	12487(Tax:10090)	Gene	Gene	domain|nummod|START_ENTITY controls|nsubj|domain controls|dobj|localization localization|nmod|CTLA-4 CTLA-4|compound|END_ENTITY	CD80 cytoplasmic domain controls localization of CD28 , CTLA-4 , and protein kinase Ctheta in the immunological synapse .
16703581	0	CD80	47,51	CD28	41,45	CD80	CD28	941	940	Gene	Gene	CTLA-4|nummod|START_ENTITY CTLA-4|nummod|END_ENTITY	Plasma concentrations of soluble CTLA-4 , CD28 , CD80 and CD86 costimulatory molecules reflect disease severity of acute_asthma in children .
16708397	0	CD80	88,92	CD28	15,19	CD80	CD28	941	940	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Integration Integration|nmod|END_ENTITY	Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86 .
17953528	0	CD80	81,85	CD28	95,99	CD80	CD28	941	940	Gene	Gene	binds|compound|START_ENTITY binds|nmod|END_ENTITY	Human Soluble CD80 is generated by alternative splicing , and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation .
7534620	0	CD80	12,16	CD28	87,91	CD80	CD28	941	940	Gene	Gene	B7-1|appos|START_ENTITY bind|nsubj|B7-1 bind|nmod|receptors receptors|compound|END_ENTITY	Human B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors .
7544393	0	CD80	46,50	CD28	101,105	CD80	CD28	941	940	Gene	Gene	domain|nmod|START_ENTITY residues|nmod|domain Identification|nmod|residues implicated|nsubj|Identification implicated|nmod|END_ENTITY	Identification of residues in the V domain of CD80 -LRB- B7-1 -RRB- implicated in functional interactions with CD28 and CTLA4 .
7577797	0	CD80	13,17	CD28	0,4	CD80	CD28	941	940	Gene	Gene	induce|nsubj|START_ENTITY ligands|ccomp|induce ligands|nsubj|END_ENTITY	CD28 ligands CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- induce long-term autocrine growth of CD4 + T cells and induce similar patterns of cytokine secretion in vitro .
8609386	0	CD80	16,20	CD28	35,39	CD80	CD28	941	940	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of CD80 and CD86 with CD28 and CTLA4 .
8683128	0	CD80	71,75	CD28	39,43	CD80	CD28	941	940	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|site site|nmod|interaction interaction|nmod|END_ENTITY	Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function .
8921441	0	CD80	118,122	CD28	0,4	CD80	CD28	941	940	Gene	Gene	induced|nmod|START_ENTITY co-signals|acl|induced 3-kinase|dep|co-signals differ|xcomp|3-kinase differ|nsubj|regimes regimes|nummod|END_ENTITY	CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase : common co-signals induced by CD80 and CD86 .
9053440	0	CD80	0,4	CD28	23,27	CD80	CD28	941	940	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	CD80 -LRB- B7-1 -RRB- binds both CD28 and CTLA-4 with a low affinity and very fast kinetics .
9915850	0	CD80	0,4	CD28	92,96	CD80	CD28	941	940	Gene	Gene	equivalent|nsubj|START_ENTITY equivalent|nmod|ability ability|acl|induce induce|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28 .
16113601	0	CD80	105,109	CD54	99,103	CD80	CD54	12519(Tax:10090)	15894(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54 , CD80 , CD86 , and CD137L generate antitumor immunity in mice .
7495758	0	CD80	67,71	CD54	124,128	CD80	CD54	941	3383	Gene	Gene	B7|appos|START_ENTITY dependent|nmod|B7 dependent|nmod|expression expression|compound|END_ENTITY	The primary alloresponse of human CD4 + T cells is dependent on B7 -LRB- CD80 -RRB- , augmented by CD58 , but relatively uninfluenced by CD54 expression .
10438973	0	CD80	26,30	CD86	6,10	CD80	CD86	941	942	Gene	Gene	.1|appos|START_ENTITY .2|nmod|.1 .2|appos|END_ENTITY	B7 .2 -LRB- CD86 -RRB- but not B7 .1 -LRB- CD80 -RRB- costimulation is required for the induction of low dose oral tolerance .
10623812	0	CD80	71,75	CD86	87,91	CD80	CD86	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Vaccination with mouse mammary adenocarcinoma cells coexpressing B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- discloses the dominant effect of B7-1 in the induction of antitumor immunity .
11137584	0	CD80	61,65	CD86	77,81	CD80	CD86	941	942	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Expression and function of the costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- in an in vitro model of the human blood -- brain barrier .
11702979	0	CD80	111,115	CD86	90,94	CD80	CD86	941	942	Gene	Gene	molecule|appos|START_ENTITY molecule|amod|B7-2 B7-2|dep|END_ENTITY	Langerhans ' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 -LRB- CD86 -RRB- , but not B7-1 -LRB- CD80 -RRB- .
12028560	0	CD80	0,4	CD86	73,77	CD80	CD86	941	942	Gene	Gene	expression|compound|START_ENTITY induced|nsubjpass|expression induced|nmod|cells cells|nmod|stimulation stimulation|nmod|END_ENTITY	CD80 expression is induced on activated B cells following stimulation by CD86 .
12053584	0	CD80	61,65	CD86	74,78	CD80	CD86	941	942	Gene	Gene	.1|appos|START_ENTITY .1|appos|.2 .2|appos|END_ENTITY	-LSB- The effect of inactivation of co-stimulated particles B7 .1 -LRB- CD80 -RRB- , B7 .2 -LRB- CD86 -RRB- on T lymphocyte activity -RSB- .
12878358	0	CD80	25,29	CD86	34,38	CD80	CD86	941	942	Gene	Gene	number|nmod|START_ENTITY number|appos|END_ENTITY	Changes in the number of CD80 -LRB- + -RRB- , CD86 -LRB- + -RRB- , and CD28 -LRB- + -RRB- peripheral blood lymphocytes have prognostic value in melanoma patients .
16113601	0	CD80	105,109	CD86	111,115	CD80	CD86	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54 , CD80 , CD86 , and CD137L generate antitumor immunity in mice .
7535614	0	CD80	45,49	CD86	61,65	CD80	CD86	941	942	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Immunoglobulin fold characteristics of B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- .
7539761	0	CD80	82,86	CD86	39,43	CD80	CD86	941	942	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene encoding|nmod|region encoding|dobj|maps maps|amod|END_ENTITY	CD28/CTLA -4 ligands : the gene encoding CD86 -LRB- B70/B7 .2 -RRB- maps to the same region as CD80 -LRB- B7/B7 .1 -RRB- gene in human chromosome 3q13-q23 .
9141426	0	CD80	44,48	CD86	60,64	CD80	CD86	941	942	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Expression of costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- on human hepatocellular_carcinoma .
9175908	0	CD80	12,16	CD86	103,107	CD80	CD86	941	942	Gene	Gene	expression|compound|START_ENTITY Analysis|nmod|expression reveals|nsubj|Analysis reveals|dobj|expression expression|nmod|END_ENTITY	Analysis of CD80 and CD86 expression on peripheral blood B lymphocytes reveals increased expression of CD86 in lupus patients .
9176106	0	CD80	75,79	CD86	91,95	CD80	CD86	941	942	Gene	Gene	B7-1|dep|START_ENTITY costimulation|amod|B7-1 costimulation|appos|END_ENTITY	Mitogenic stimulation of T cells reveals differing contributions for B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- costimulation .
9217815	0	CD80	42,46	CD86	58,62	CD80	B7-1	12519(Tax:10090)	941	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Blockade of costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- down-regulates induction of contact sensitivity by haptenated epidermal cells .
9498744	0	CD80	120,124	CD86	136,140	CD80	CD86	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	B7-1|dep|START_ENTITY molecules|amod|B7-1 molecules|appos|END_ENTITY	IL-12 reverses established antigen-specific tolerance of contact_sensitivity by affecting costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- .
9548473	0	CD80	46,50	CD86	62,66	CD80	CD86	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Functional consequences of dysregulated B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- expression in B or T lymphocytes of transgenic_mice .
9743334	0	CD80	72,76	CD86	88,92	CD80	CD86	12519(Tax:10090)	12524(Tax:10090)	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Studies using antigen-presenting cells lacking expression of both B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production .
9846836	0	CD80	6,10	CD86	19,23	CD80	CD86	941	942	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|B7-2 B7-2|appos|END_ENTITY	B7-1 -LRB- CD80 -RRB- , B7-2 -LRB- CD86 -RRB- , interleukin-12 and transforming_growth_factor-beta mRNA expression in CSF and peripheral blood mononuclear cells from multiple_sclerosis patients .
24981893	0	CD80	62,66	CD95	28,32	CD80	CD95	941	355	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of death receptor CD95 and co-stimulatory molecules CD80 and CD86 by meningococcal capsular polysaccharide-loaded vaccine nanoparticles .
9144510	0	CD80	79,83	IFN-gamma	23,32	CD80	IFN-gamma	12519(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 -LRB- B7-1 -RRB- but not CD86 -LRB- B7-2 -RRB- on murine fibroblasts .
21469977	0	CD80	73,77	S-100	31,36	CD80	S-100	941	6285	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and distribution of S-100 , CD83 , and costimulatory molecules -LRB- CD80 and CD86 -RRB- in tissues of thyroid_papillary_carcinoma .
11842537	0	CD80	50,54	costimulatory_adhesion_molecule	17,48	CD80	costimulatory adhesion molecule	25408(Tax:10116)	25408(Tax:10116)	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	-LSB- Upregulation of costimulatory_adhesion_molecule -LRB- CD80 -RRB- in rat kidney with ischemia/reperfusion injury -RSB- .
23831410	0	CD80	77,81	hnRNP_C	20,27	CD80	hnRNP C	12519(Tax:10090)	15381(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The splicing factor hnRNP_C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells .
9003466	0	CD80	42,46	interferon_gamma	105,121	CD86	interferon gamma	942	3458	Gene	Gene	expression|nmod|START_ENTITY expression|dep|regulation regulation|nmod|END_ENTITY	The expression of costimulatory molecules CD80 and CD86 in human carcinoma cell lines : its regulation by interferon_gamma and interleukin-10 .
21274737	0	CD80	58,62	thymic_stromal_lymphopoietin	6,34	CD80	thymic stromal lymphopoietin	941	85480	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Human thymic_stromal_lymphopoietin enhances expression of CD80 in human CD14 + monocytes/macrophages .
14966136	0	CD81	0,4	14-3-3	21,27	CD81	14-3-3	975	10971	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner .
14530327	0	CD81	16,20	CD19	49,53	CD81	CD19	975	930	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment .
19828092	0	CD81	0,4	CD19	19,23	CD81	CD19	975	930	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	CD81 expression on CD19 + peripheral blood lymphocytes is associated with chronic_HCV_disease and increased risk for HCV_infection : a putative role for inflammatory cytokines .
20237408	0	CD81	0,4	CD19	36,40	CD81	CD19	975	930	Gene	Gene	defect|compound|START_ENTITY disrupts|nsubj|defect disrupts|dobj|formation formation|nummod|END_ENTITY	CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody_deficiency .
15230853	0	CD81	33,37	CD81	88,92	CD81	CD81	975	975	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Mutations in the putative HCV-E2 CD81 binding regions and correlation with cell surface CD81 expression .
15230853	0	CD81	88,92	CD81	33,37	CD81	CD81	975	975	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Mutations in the putative HCV-E2 CD81 binding regions and correlation with cell surface CD81 expression .
26195630	0	CD81	16,20	PCSK9	36,41	CD81	PCSK9	975	255738	Gene	Gene	complexes|compound|START_ENTITY complexes|nmod|END_ENTITY	Plasma membrane CD81 complexes with PCSK9 and LDLR and its levels are reduced by PCSK9 .
26195630	0	CD81	16,20	PCSK9	36,41	CD81	PCSK9	975	255738	Gene	Gene	complexes|compound|START_ENTITY complexes|nmod|END_ENTITY	Plasma membrane CD81 complexes with PCSK9 and LDLR and its levels are reduced by PCSK9 .
24549717	0	CD81	97,101	SRBI	104,108	CD81	SRBI	975	949	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Generation of infectious HCV pseudo typed particles and its utilization for studying the role of CD81 _ SRBI receptors in HCV_infection .
12597781	0	CD81	6,10	Th1	29,32	CD81	Th1	975	51497	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Human CD81 directly enhances Th1 and Th2 cell activation , but preferentially induces proliferation of Th2 cells upon long-term stimulation .
9482907	0	CD81	0,4	interleukin_4	25,38	CD81	interleukin 4	12520(Tax:10090)	16189(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|secretion secretion|amod|END_ENTITY	CD81 on B cells promotes interleukin_4 secretion and antibody production during T helper type 2 immune responses .
25635054	0	CD81	0,4	transferrin_receptor_2	38,60	CD81	transferrin receptor 2	975	7036	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	CD81 promotes both the degradation of transferrin_receptor_2 -LRB- TfR2 -RRB- and the Tfr2-mediated maintenance of hepcidin expression .
23055153	0	CD82	68,72	CD38	8,12	CD82	CD38	12521(Tax:10090)	12494(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	CD34 ___ / CD38 ___ acute_myelogenous_leukemia cells aberrantly express CD82 which regulates adhesion and survival of leukemia stem cells .
25955299	0	CD82	27,31	EZH2	57,61	CD82	EZH2	3732	2146	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Tetraspanin Family Member , CD82 , Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells .
17178712	0	CD83	87,91	APRIL	60,65	CD83	APRIL	9308	10541	Gene	Gene	expression|compound|START_ENTITY ligand|nmod|expression ligand|dobj|END_ENTITY	Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression .
19130553	0	CD83	69,73	APRIL	34,39	CD83	APRIL	9308	10541	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression .
10962529	0	CD83	6,10	CD1a	12,16	CD83	CD1a	9308	909	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	CD68 + / CD83 + / CD1a - dendritic cell subsets from patients with multiple_myeloma are not infected with human_herpesvirus_8 .
15213252	0	CD83	105,109	CD1a	94,98	CD83	CD1a	9308	909	Gene	Gene	myeloid|nsubj|START_ENTITY myeloid|ccomp|transforms transforms|nmod|END_ENTITY	IL-4 alone without the involvement of GM-CSF transforms human peripheral blood monocytes to a CD1a -LRB- dim -RRB- , CD83 -LRB- + -RRB- myeloid dendritic cell subset .
11955430	0	CD83	0,4	CD4	27,30	CD83	CD4	12522(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY influences|nsubj|expression influences|dobj|development development|compound|END_ENTITY	CD83 expression influences CD4 + T cell development in the thymus .
15322158	0	CD83	20,24	CD4	78,81	CD83	CD4	12522(Tax:10090)	12504(Tax:10090)	Gene	Gene	mutation|nmod|START_ENTITY results|nsubj|mutation results|nmod|development development|nmod|population population|nmod|cells cells|compound|END_ENTITY	A novel mutation in CD83 results in the development of a unique population of CD4 + T cells .
18424708	0	CD83	0,4	CD4	19,22	CD83	CD4	12522(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD83 expression in CD4 + T cells modulates inflammation and autoimmunity .
25997495	0	CD83	25,29	CD4	49,52	CD83	CD4	9308	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Continuous expression of CD83 on activated human CD4 + T cells is correlated with their differentiation into induced regulatory T cells .
18070479	5	CD83	919,923	CD86	913,917	CD83	CD86	12522(Tax:10090)	12524(Tax:10090)	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	RESULTS : ox-LDL-treated RAW264 .7 murine macrophage cell line differentiated into dendritic like cells after 48 h and cell surface markers CD40 , CD86 , CD83 , MHC Class II and CD1d were upregulated .
16484227	0	CD83	14,18	HuR	35,38	CD83	HuR	9308	1994	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element .
12857898	0	CD83	56,60	Latent_membrane_protein_1	0,25	CD83	Latent membrane protein 1	9308	9260	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Latent_membrane_protein_1 of Epstein-Barr_virus induces CD83 by the NF-kappaB signaling pathway .
18162459	0	CD83	46,50	S-100	31,36	CD83	S-100	9308	6285	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression and distribution of S-100 protein , CD83 and apoptosis-related proteins -LRB- Fas , FasL and Bcl-2 -RRB- in thyroid tissues of autoimmune_thyroid_diseases .
26129803	0	CD83	65,69	Tax	35,38	CD83	Tax	9308	6900	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Human T-cell_leukemia_virus_type-I Tax induces the expression of CD83 on T cells .
23025437	0	CD84	23,27	ADAM10	44,50	CD84	ADAM10	12523(Tax:10090)	11487(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets .
11300479	0	CD84	115,119	CD84-H1	98,105	CD84	CD84-H1	8832	89886;8832;3009	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1 , a novel CD84 homologue .
11300479	0	CD84-H1	98,105	CD84	115,119	CD84-H1	CD84	89886;8832;3009	8832	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1 , a novel CD84 homologue .
15939744	0	CD85j	21,26	LAIR-1	28,34	CD85j	LAIR-1	10859	3903	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Inhibitory receptors CD85j , LAIR-1 , and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes .
10521545	0	CD86	16,20	B7-2	22,26	CD86	B7-2	942	942	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- expression in multiple_sclerosis patients : clinical subtype specific variation in peripheral monocytes and B cells and lack of modulation by high dose methylprednisolone .
15989635	0	CD86	18,22	B7-2	12,16	CD86	B7-2	942	942	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of B7-2 -LRB- CD86 -RRB- in tumour immunity .
9199963	0	CD86	30,34	B7-2	24,28	CD86	B7-2	942	942	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The IgV domain of human B7-2 -LRB- CD86 -RRB- is sufficient to co-stimulate T lymphocytes and induce cytokine secretion .
15356107	0	CD86	6,10	CD4	49,52	CD86	CD4	12524(Tax:10090)	12504(Tax:10090)	Gene	Gene	B7-2|appos|START_ENTITY controls|nsubj|B7-2 controls|dobj|priming priming|nmod|response response|compound|END_ENTITY	B7-2 -LRB- CD86 -RRB- controls the priming of autoreactive CD4 T cell response against pancreatic islets .
15788440	0	CD86	11,15	CD4	46,49	CD86	CD4	12524(Tax:10090)	12504(Tax:10090)	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	CTLA4-CD80 / CD86 interactions on primary mouse CD4 + T cells integrate signal-strength information to modulate activation with Concanavalin_A .
16339520	0	CD86	39,43	CD4	119,122	CD86	CD4	942	920	Gene	Gene	CD28|nmod|START_ENTITY Ligation|nmod|CD28 induces|nsubj|Ligation induces|dobj|polarization polarization|nmod|cells cells|compound|END_ENTITY	Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells .
22246628	0	CD86	17,21	CD4	42,45	CD86	CD4	942	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	IL-2 upregulates CD86 expression on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
10807126	0	CD86	94,98	CD44	100,104	CD86	CD44	942	960	Gene	Gene	HLA-DR|dep|START_ENTITY HLA-DR|dep|END_ENTITY	Expression of molecules involved in antigen presentation and T cell activation -LRB- HLA-DR , CD80 , CD86 , CD44 and CD54 -RRB- by cultured human osteoblasts .
16113601	0	CD86	111,115	CD54	99,103	CD86	CD54	12524(Tax:10090)	15894(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54 , CD80 , CD86 , and CD137L generate antitumor immunity in mice .
22346780	0	CD86	26,30	CD54	56,60	CD86	CD54	942	3383	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Cross-linking of CD80 and CD86 Diminishes Expression of CD54 on EBV-transformed B Cells through Inactivation of RhoA and Ras .
10438973	0	CD86	6,10	CD80	26,30	CD86	CD80	942	941	Gene	Gene	.2|appos|START_ENTITY .2|nmod|.1 .1|appos|END_ENTITY	B7 .2 -LRB- CD86 -RRB- but not B7 .1 -LRB- CD80 -RRB- costimulation is required for the induction of low dose oral tolerance .
10623812	0	CD86	87,91	CD80	71,75	CD86	CD80	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Vaccination with mouse mammary adenocarcinoma cells coexpressing B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- discloses the dominant effect of B7-1 in the induction of antitumor immunity .
11137584	0	CD86	77,81	CD80	61,65	CD86	CD80	942	941	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Expression and function of the costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- in an in vitro model of the human blood -- brain barrier .
11702979	0	CD86	90,94	CD80	111,115	CD86	CD80	942	941	Gene	Gene	B7-2|dep|START_ENTITY molecule|amod|B7-2 molecule|appos|END_ENTITY	Langerhans ' cells in vernal keratoconjunctivitis express the costimulatory molecule B7-2 -LRB- CD86 -RRB- , but not B7-1 -LRB- CD80 -RRB- .
12028560	0	CD86	73,77	CD80	0,4	CD86	CD80	942	941	Gene	Gene	stimulation|nmod|START_ENTITY cells|nmod|stimulation induced|nmod|cells induced|nsubjpass|expression expression|compound|END_ENTITY	CD80 expression is induced on activated B cells following stimulation by CD86 .
12053584	0	CD86	74,78	CD80	61,65	CD86	CD80	942	941	Gene	Gene	.2|appos|START_ENTITY .1|appos|.2 .1|appos|END_ENTITY	-LSB- The effect of inactivation of co-stimulated particles B7 .1 -LRB- CD80 -RRB- , B7 .2 -LRB- CD86 -RRB- on T lymphocyte activity -RSB- .
12878358	0	CD86	34,38	CD80	25,29	CD86	CD80	942	941	Gene	Gene	number|appos|START_ENTITY number|nmod|END_ENTITY	Changes in the number of CD80 -LRB- + -RRB- , CD86 -LRB- + -RRB- , and CD28 -LRB- + -RRB- peripheral blood lymphocytes have prognostic value in melanoma patients .
16113601	0	CD86	111,115	CD80	105,109	CD86	CD80	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Neuroblastoma cells transiently transfected to simultaneously express the co-stimulatory molecules CD54 , CD80 , CD86 , and CD137L generate antitumor immunity in mice .
7535614	0	CD86	61,65	CD80	45,49	CD86	CD80	942	941	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Immunoglobulin fold characteristics of B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- .
7539761	0	CD86	39,43	CD80	82,86	CD86	CD80	942	941	Gene	Gene	maps|amod|START_ENTITY encoding|dobj|maps encoding|nmod|region region|nmod|gene gene|compound|END_ENTITY	CD28/CTLA -4 ligands : the gene encoding CD86 -LRB- B70/B7 .2 -RRB- maps to the same region as CD80 -LRB- B7/B7 .1 -RRB- gene in human chromosome 3q13-q23 .
9141426	0	CD86	60,64	CD80	44,48	CD86	CD80	942	941	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Expression of costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- on human hepatocellular_carcinoma .
9175908	0	CD86	103,107	CD80	12,16	CD86	CD80	942	941	Gene	Gene	expression|nmod|START_ENTITY reveals|dobj|expression reveals|nsubj|Analysis Analysis|nmod|expression expression|compound|END_ENTITY	Analysis of CD80 and CD86 expression on peripheral blood B lymphocytes reveals increased expression of CD86 in lupus patients .
9176106	0	CD86	91,95	CD80	75,79	CD86	CD80	942	941	Gene	Gene	costimulation|appos|START_ENTITY costimulation|amod|B7-1 B7-1|dep|END_ENTITY	Mitogenic stimulation of T cells reveals differing contributions for B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- costimulation .
9217815	0	CD86	58,62	CD80	42,46	B7-1	CD80	941	12519(Tax:10090)	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Blockade of costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- down-regulates induction of contact sensitivity by haptenated epidermal cells .
9498744	0	CD86	136,140	CD80	120,124	CD86	CD80	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	molecules|appos|START_ENTITY molecules|amod|B7-1 B7-1|dep|END_ENTITY	IL-12 reverses established antigen-specific tolerance of contact_sensitivity by affecting costimulatory molecules B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- .
9548473	0	CD86	62,66	CD80	46,50	CD86	CD80	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Functional consequences of dysregulated B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- expression in B or T lymphocytes of transgenic_mice .
9743334	0	CD86	88,92	CD80	72,76	CD86	CD80	12524(Tax:10090)	12519(Tax:10090)	Gene	Gene	B7-1|appos|START_ENTITY B7-1|appos|END_ENTITY	Studies using antigen-presenting cells lacking expression of both B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production .
9846836	0	CD86	19,23	CD80	6,10	CD86	CD80	942	941	Gene	Gene	B7-2|appos|START_ENTITY B7-1|appos|B7-2 B7-1|appos|END_ENTITY	B7-1 -LRB- CD80 -RRB- , B7-2 -LRB- CD86 -RRB- , interleukin-12 and transforming_growth_factor-beta mRNA expression in CSF and peripheral blood mononuclear cells from multiple_sclerosis patients .
18070479	5	CD86	913,917	CD83	919,923	CD86	CD83	12524(Tax:10090)	12522(Tax:10090)	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	RESULTS : ox-LDL-treated RAW264 .7 murine macrophage cell line differentiated into dendritic like cells after 48 h and cell surface markers CD40 , CD86 , CD83 , MHC Class II and CD1d were upregulated .
12734361	0	CD86	53,57	IgG1	31,35	CD86	IgG1	12524(Tax:10090)	16017(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|END_ENTITY	Selective regulation of mature IgG1 transcription by CD86 and beta 2-adrenergic receptor stimulation .
24136171	0	CD86	43,47	PKC-b	8,13	CD86	PKC-b	942	5579	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of PKC-b in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells .
12423654	0	CD86	14,18	THP-1	75,80	CD86	THP-1	942	2736	Gene	Gene	expression|nummod|START_ENTITY Evaluation|nmod|expression internalization|nsubj|Evaluation internalization|nmod|cells cells|compound|END_ENTITY	Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers .
21628959	0	CD86	25,29	THP-1	122,127	CD86	THP-1	942	2736	Gene	Gene	relationship|nmod|START_ENTITY protein|nsubj|relationship protein|dobj|stimulation stimulation|nmod|allergen allergen|nmod|cells cells|compound|END_ENTITY	The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells .
24136171	0	CD86	43,47	THP-1	79,84	CD86	THP-1	942	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Role of PKC-b in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells .
20967855	0	CD87	64,68	UPAR	58,62	CD87	UPAR	5329	5329	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A genetic variation located in the promoter region of the UPAR -LRB- CD87 -RRB- gene is associated with the vascular complications of systemic_sclerosis .
10410988	0	CD87	42,46	Urokinase_plasminogen_activator_receptor	0,40	CD87	Urokinase plasminogen activator receptor	5329	5329	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Urokinase_plasminogen_activator_receptor -LRB- CD87 -RRB- expression of tumor-associated macrophages in ductal_carcinoma in situ , breast_cancer , and resident macrophages of normal breast tissue .
21638078	0	CD87	50,54	urokinase_plasminogen_activator_receptor	8,48	CD87	urokinase plasminogen activator receptor	5329	5329	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of urokinase_plasminogen_activator_receptor -LRB- CD87 -RRB- as a prognostic marker in acute_myeloid_leukemia .
8955209	0	CD88	54,58	C3a	31,34	CD88	C3a	728	718	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of the C3a and C5a_receptors -LRB- CD88 -RRB- by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines .
23394121	0	CD88	46,50	C5a	31,34	CD88	C5a	728	728	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Complement activation fragment C5a receptors , CD88 and C5L2 , are associated with neurofibrillary pathology .
12070675	0	CD88	47,51	C5aR	41,45	CD88	C5aR	728	728	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the anaphylatoxin receptor C5aR -LRB- CD88 -RRB- by human articular chondrocytes .
10996218	0	CD88	39,43	C5a_receptor	25,37	CD88	C5a receptor	12273(Tax:10090)	12273(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Intracerebral complement C5a_receptor -LRB- CD88 -RRB- expression is regulated by TNF and lymphotoxin-alpha following closed_head_injury in mice .
12225614	0	CD88	32,36	C5a_receptor	18,30	CD88	C5a receptor	728	728	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the C5a_receptor -LRB- CD88 -RRB- on granulocytes and monocytes in patients with severe sepsis .
22249919	0	CD88	14,18	C5a_receptor	0,12	CD88	C5a receptor	728	728	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	C5a_receptor -LRB- CD88 -RRB- inhibition improves hypothermia-induced neuroprotection in an in vitro ischemic model .
8911150	0	CD88	43,47	C5a_receptor	29,41	CD88	C5a receptor	728	728	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and modulation of C5a_receptor -LRB- CD88 -RRB- on skin dendritic cells .
9286351	0	CD88	54,58	C5a_receptor	40,52	CD88	C5a receptor	728	728	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Functional expression and modulation of C5a_receptor -LRB- CD88 -RRB- on skin dendritic cells .
9485081	0	CD88	32,36	C5a_receptor	18,30	CD88	C5a receptor	728	728	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the C5a_receptor -LRB- CD88 -RRB- on synovial mast cells in patients with rheumatoid_arthritis .
8955209	0	CD88	54,58	IFN-gamma	63,72	CD88	IFN-gamma	728	3458	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of the C3a and C5a_receptors -LRB- CD88 -RRB- by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines .
12244179	0	CD89	57,61	Fc_alpha_R	45,55	CD89	Fc alpha R	2204	2204	Gene	Gene	binding|appos|START_ENTITY binding|compound|END_ENTITY	Mac-1 -LRB- CD11b/CD18 -RRB- as accessory molecule for Fc_alpha_R -LRB- CD89 -RRB- binding of IgA .
11369640	0	CD89	52,56	FcalphaR	42,50	CD89	FcalphaR	2204	2204	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Cytokine-induced inside-out activation of FcalphaR -LRB- CD89 -RRB- is mediated by a single serine residue -LRB- S263 -RRB- in the intracellular domain of the receptor .
10839814	0	CD89	18,22	IgA	70,73	CD89	IgA	2204	12518(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY mediates|nsubj|receptor mediates|dobj|development development|nmod|nephropathy nephropathy|appos|END_ENTITY	Fcalpha receptor -LRB- CD89 -RRB- mediates the development of immunoglobulin_A -LRB- IgA -RRB- nephropathy -LRB- Berger 's _ disease -RRB- .
15371488	0	CD89	55,59	IgA	40,43	CD89	IgA	2204	973	Gene	Gene	expression|appos|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	Differential expression and function of IgA receptors -LRB- CD89 and CD71 -RRB- during maturation of dendritic cells .
23201915	0	CD89	47,51	IgA	30,33	CD89	IgA	2204	973	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Anti-inflammatory role of the IgA Fc receptor -LRB- CD89 -RRB- : from autoimmunity to therapeutic perspectives .
9870466	0	CD89	117,121	IgA	100,103	CD89	IgA	2204	973	Gene	Gene	binding|appos|START_ENTITY binding|amod|nephropathy nephropathy|nmod|Fc-receptor Fc-receptor|compound|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9870466	0	CD89	117,121	IgA	37,40	CD89	IgA	2204	973	Gene	Gene	binding|appos|START_ENTITY binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9870466	0	CD89	117,121	IgA	69,72	CD89	IgA	2204	973	Gene	Gene	binding|appos|START_ENTITY binding|nmod|patients patients|nmod|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
15379978	0	CD89	47,51	immunoglobulin_A	53,69	CD89	immunoglobulin A	2204	973	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	Identification and characterization of macaque CD89 -LRB- immunoglobulin_A Fc receptor -RRB- .
9870466	0	CD89	117,121	immunoglobulin_A	19,35	CD89	immunoglobulin A	2204	973	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
8952962	0	CD8A	65,69	CD4	84,87	CD8A	CD4	925	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Post-transcriptional regulation associated with control of human CD8A expression of CD4 + T cells .
10553054	0	CD8_alpha	12,21	CD4	30,33	CD8 alpha	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of CD8_alpha ' in the CD4 versus CD8 lineage choice .
1460418	0	CD8_alpha	41,50	CD4	90,93	CD8 alpha	CD4	24930(Tax:10116)	24932(Tax:10116)	Gene	Gene	chains|amod|START_ENTITY chains|nmod|cells cells|compound|END_ENTITY	Glucocorticoids induce the expression of CD8_alpha chains on concanavalin A-activated rat CD4 + T cells : induction is inhibited by rat recombinant interleukin_4 .
15114659	0	CD8_alpha	0,9	CD4	61,64	CD8 alpha	CD4	24930(Tax:10116)	24932(Tax:10116)	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|subset subset|nmod|cells cells|compound|END_ENTITY	CD8_alpha is an activation marker for a subset of peripheral CD4 T cells .
7614985	0	CD8_alpha	17,26	CD4	30,33	CD8 alpha	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Co-expression of CD8_alpha in CD4 + T cell receptor alpha beta + T cells migrating into the murine small intestine epithelial layer .
7876540	1	CD8_alpha	181,190	CD4	142,145	CD8 alpha	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY induced|xcomp|express induced|nsubjpass|Evidence Evidence|acl:relcl|mature mature|dobj|cells cells|compound|END_ENTITY	Evidence that mature post-thymic CD4 + T cells can be induced to express CD8_alpha in vivo .
8426123	0	CD8_alpha	172,181	CD4	82,85	CD8 alpha	CD4	24930(Tax:10116)	24932(Tax:10116)	Gene	Gene	T|compound|START_ENTITY pathway|nmod|T initiating|dobj|pathway rat|acl|initiating rat|dep|thymocytes thymocytes|nummod|,8 ,8|compound|END_ENTITY	T cell receptor ligation induces interleukin -LRB- IL -RRB- 2R beta chain expression in rat CD4 ,8 double positive thymocytes , initiating an IL-2-dependent differentiation pathway of CD8_alpha + / beta - T cells .
9551905	0	CD8_alpha	154,163	CD4	38,41	CD8 alpha	CD4	24930(Tax:10116)	12504(Tax:10090)	Gene	Gene	chain|amod|START_ENTITY expression|nmod|chain correlation|nmod|expression signals|dep|correlation lineage|nmod|signals lineage|dobj|decisions decisions|nmod|mouse mouse|nummod|+8 +8|compound|END_ENTITY	Opposite CD4/CD8 lineage decisions of CD4 +8 + mouse and rat thymocytes to equivalent triggering signals : correlation with thymic expression of a truncated CD8_alpha chain in mice but not rats .
19635904	0	CD8_alpha	43,52	IPS-1	78,83	CD8 alpha	IPS-1	12525(Tax:10090)	228607(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Poly_I : C-induced activation of NK cells by CD8_alpha + dendritic cells via the IPS-1 and TRIF-dependent pathways .
1905643	0	CD8_alpha	22,31	Interleukin_4	0,13	CD8 alpha	Interleukin 4	12525(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_4 induces CD8_alpha expression on T cell receptor V gamma 5 thymocytes .
22934250	0	CD8a	113,117	CD11c	104,109	CD8a	CD11c	12525(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|dep|START_ENTITY END_ENTITY|dep|cells	Cross-priming for antitumor CTL induced by soluble Ag + polyI : C depends on the TICAM-1 pathway in mouse CD11c -LRB- + -RRB- / CD8a -LRB- + -RRB- dendritic cells .
22066016	0	CD8a	30,34	CD4	16,19	CD8a	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Spleen-resident CD4 + and CD4 - CD8a - dendritic cell subsets differ in their ability to prime invariant natural killer T lymphocytes .
23738014	0	CD8a	25,29	CD4	126,129	CD8a	CD4	925	920	Gene	Gene	domains|nmod|START_ENTITY cells|nsubj|domains cells|amod|sufficient sufficient|nmod|I I|acl|restricted restricted|dobj|functions functions|nmod|T T|compound|END_ENTITY	Extracellular domains of CD8a and CD8 subunits are sufficient for HLA class I restricted helper functions of TCR-engineered CD4 -LRB- + -RRB- T cells .
22025728	0	CD8a	43,47	CD8	72,75	CD8a	CD8	925	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Cd8 enhancer E8I and Runx factors regulate CD8a expression in activated CD8 + T cells .
23284054	0	CD8a	70,74	TLR7	0,4	CD8a	TLR7	12525(Tax:10090)	170743(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	TLR7 triggering with polyuridylic_acid promotes cross-presentation in CD8a + conventional dendritic cells by enhancing antigen preservation and MHC_class_I_antigen permanence on the dendritic cell surface .
15327893	0	CD8alpha	48,56	CC_chemokine_ligand_3	4,25	CD8alpha	CC chemokine ligand 3	12525(Tax:10090)	20302(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The CC_chemokine_ligand_3 regulates CD11c + CD11b + CD8alpha - dendritic cell maturation and activation following viral_infection_of_the_central_nervous_system : implications for a role in T cell activation .
12091350	0	CD8alpha	107,115	CD11c	27,32	CD8alpha	CD11c	12525(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY precursor|nmod|cells cells|nmod|precursor Identification|dep|cells Identification|nmod|END_ENTITY	Identification of CD8alpha + CD11c - lineage phenotype-negative cells in the spleen as committed precursor of CD8alpha + dendritic cells .
17760559	0	CD8alpha	127,135	CD11c	121,126	CD8alpha	CD11c	12525(Tax:10090)	16411(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Big tumor regression induced by GM-CSF gene-modified 3LL tumor cells via facilitating DC maturation and deviation toward CD11c + CD8alpha + subset .
10560824	0	CD8alpha	97,105	CD4	28,31	CD8alpha	CD4	100126556(Tax:9103)	100126554(Tax:9103)	Gene	Gene	molecule|compound|START_ENTITY polymorphism|nmod|molecule suggest|dobj|polymorphism suggest|nsubj|END_ENTITY	Cross-reactive anti-chicken CD4 and CD8 monoclonal antibodies suggest polymorphism of the turkey CD8alpha molecule .
11001905	0	CD8alpha	75,83	CD4	138,141	CD8alpha	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	revisited|dep|START_ENTITY cells|amod|revisited generated|nsubjpass|cells generated|advcl|END_ENTITY	Concept of lymphoid versus myeloid dendritic cell lineages revisited : both CD8alpha -LRB- - -RRB- and CD8alpha -LRB- + -RRB- dendritic cells are generated from CD4 -LRB- low -RRB- lymphoid-committed precursors .
14607905	0	CD8alpha	0,8	CD4	73,76	CD8alpha	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY controls|nsubj|+ controls|dobj|immunity immunity|compound|END_ENTITY	CD8alpha + and CD11b + dendritic cell-restricted MHC class II controls Th1 CD4 + T cell immunity .
15496961	0	CD8alpha	132,140	CD4	18,21	CD8alpha	CD4	925	920	Gene	Gene	requires|dobj|START_ENTITY requires|dep|Redirecting Redirecting|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Redirecting human CD4 + T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha .
16836648	0	CD8alpha	14,22	CD4	71,74	CD8alpha	CD4	925	920	Gene	Gene	Expression|nmod|START_ENTITY identifies|nsubj|Expression identifies|dobj|subset subset|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Expression of CD8alpha identifies a distinct subset of effector memory CD4 + T lymphocytes .
17313653	2	CD8alpha	115,123	CD4	172,175	CD8alpha	CD4	925	920	Gene	Gene	Expression|nmod|START_ENTITY identifies|nsubj|Expression identifies|dobj|subset subset|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Expression of CD8alpha identifies a distinct subset of effector memory CD4 T lymphocytes .
17610959	0	CD8alpha	0,8	CD4	55,58	CD8alpha	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|enhance enhance|dobj|response response|compound|END_ENTITY	CD8alpha + dendritic cells enhance the antigen-specific CD4 + T-cell response and accelerate development of collagen-induced_arthritis .
20394075	0	CD8alpha	0,8	CD4	64,67	CD8alpha	CD4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|dep|FOXP3 FOXP3|compound|END_ENTITY	CD8alpha + dendritic cells prime TCR-peptide-reactive regulatory CD4 + FOXP3 - T cells .
9022017	0	CD8alpha	63,71	CD4	19,22	CD8alpha	CD4	428800(Tax:9031)	395362(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY inheritance|nmod|expression population|dep|inheritance population|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9022017	0	CD8alpha	63,71	CD4	86,89	CD8alpha	CD4	428800(Tax:9031)	395362(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9139839	0	CD8alpha	35,43	CD4	30,33	CD8alpha	CD4	925	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of an enriched CD4 + CD8alpha + + CD8beta + T-cell subset among tumor-infiltrating lymphocytes in human renal_cell_carcinoma .
9022017	0	CD8alpha	63,71	CD8	24,27	CD8alpha	CD8	428800(Tax:9031)	428800(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY inheritance|nmod|expression population|dep|inheritance population|compound|END_ENTITY	A novel peripheral CD4 + CD8 + T cell population : inheritance of CD8alpha expression on CD4 + T cells .
9139839	0	CD8alpha	35,43	CD8beta	46,53	CD8alpha	CD8beta	925	926	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of an enriched CD4 + CD8alpha + + CD8beta + T-cell subset among tumor-infiltrating lymphocytes in human renal_cell_carcinoma .
20394075	0	CD8alpha	0,8	FOXP3	68,73	CD8alpha	FOXP3	12525(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|dep|END_ENTITY	CD8alpha + dendritic cells prime TCR-peptide-reactive regulatory CD4 + FOXP3 - T cells .
12393690	0	CD8alpha	62,70	ICSBP	19,24	CD8alpha	ICSBP	12525(Tax:10090)	15900(Tax:10090)	Gene	Gene	development|nmod|START_ENTITY END_ENTITY|nmod|development	Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells .
15496961	0	CD8alpha	132,140	MAGE-A1	84,91	CD8alpha	MAGE-A1	925	4100	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Redirecting human CD4 + T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha .
12393564	0	CD8alpha	79,87	TCRalpha	99,107	CD8alpha	TCRalpha	925	28755	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|compound|END_ENTITY	CD8alpha alpha memory effector T cells descend directly from clonally expanded CD8alpha + beta high TCRalpha beta T cells in vivo .
14607905	0	CD8alpha	0,8	Th1	69,72	CD8alpha	Th1	12525(Tax:10090)	57314(Tax:10090)	Gene	Gene	+|compound|START_ENTITY controls|nsubj|+ controls|dobj|immunity immunity|compound|END_ENTITY	CD8alpha + and CD11b + dendritic cell-restricted MHC class II controls Th1 CD4 + T cell immunity .
21821134	0	CD8b	30,34	CD4	25,28	CD8b	CD4	100136451(Tax:8030)	100169855(Tax:8030)	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of CD3 , CD4 , CD8b splice variants of Atlantic_salmon .
10552959	0	CD8beta	47,54	CD4	75,78	CD8beta	CD4	926	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|CD8alphaalpha CD8alphaalpha|compound|END_ENTITY	Beta-selection is associated with the onset of CD8beta chain expression on CD4 -LRB- + -RRB- CD8alphaalpha -LRB- + -RRB- pre-T cells during human intrathymic development .
9139839	0	CD8beta	46,53	CD4	30,33	CD8beta	CD4	926	920	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of an enriched CD4 + CD8alpha + + CD8beta + T-cell subset among tumor-infiltrating lymphocytes in human renal_cell_carcinoma .
9139839	0	CD8beta	46,53	CD8alpha	35,43	CD8beta	CD8alpha	926	925	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Identification of an enriched CD4 + CD8alpha + + CD8beta + T-cell subset among tumor-infiltrating lymphocytes in human renal_cell_carcinoma .
23289620	0	CD9	20,23	CD10	55,59	CD9	CD10	928	4311	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes .
9804823	0	CD9	53,56	CD19	0,4	CD9	CD19	928	930	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	CD19 is linked to the integrin-associated tetraspans CD9 , CD81 , and CD82 .
24466195	0	CD9	0,3	CD26	25,29	CD9	CD26	928	1803	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	CD9 negatively regulates CD26 expression and inhibits CD26-mediated enhancement of invasive potential of malignant_mesothelioma cells .
11091638	0	CD9	8,11	CD31	31,35	CD9	CD31	928	5175	Gene	Gene	START_ENTITY|nmod|Expression Expression|nmod|END_ENTITY	Loss of CD9 with Expression of CD31 and VEGF in Breast_Carcinoma , as Predictive Factors of Lymph Node Metastasis .
11238109	0	CD9	21,24	CD36	0,4	CD9	CD36	928	948	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	CD36 associates with CD9 and integrins on human blood platelets .
22216174	0	CD9	0,3	CD36	31,35	CD9	CD36	12527(Tax:10090)	12491(Tax:10090)	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	CD9 tetraspanin interacts with CD36 on the surface of macrophages : a possible regulatory influence on uptake of oxidized low density lipoprotein .
19692500	0	CD9	0,3	GCM1	35,39	CD9	GCM1	928	8521	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway .
21600883	0	CD9	73,76	IFITM5	37,43	CD9	IFITM5	928	387733	Gene	Gene	association|nmod|START_ENTITY regulates|dobj|association regulates|nsubj|END_ENTITY	Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes .
20307249	0	CD9	59,62	IL-16	0,5	CD9	IL-16	928	3603	Gene	Gene	dependence|nmod|START_ENTITY effects|dep|dependence effects|compound|END_ENTITY	IL-16 effects on A549 lung epithelial cells : dependence on CD9 as an IL-16 receptor ?
20307249	0	CD9	59,62	IL-16	69,74	CD9	IL-16	928	3603	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	IL-16 effects on A549 lung epithelial cells : dependence on CD9 as an IL-16 receptor ?
16000878	0	CD9	12,15	MMP-2	24,29	CD9	MMP-2	928	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK , JNK and c-Jun pathways in human melanoma cells .
9736046	0	CD9	34,37	MRP-1	28,33	CD9	MRP-1	928	928	Gene	Gene	expression|compound|START_ENTITY Correlation|dep|expression Correlation|nmod|END_ENTITY	Correlation of reduction in MRP-1 / CD9 and KAI1/CD82 expression with recurrences in breast_cancer patients .
14735195	0	CD9	34,37	Motility-related_protein-1	0,26	CD9	Motility-related protein-1	928	928	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Motility-related_protein-1 -LRB- MRP-1 / CD9 -RRB- expression can predict disease-free survival in patients with squamous_cell_carcinoma of the head_and_neck .
7664290	0	CD9	34,37	Motility_related_protein_1	0,26	CD9	Motility related protein 1	928	928	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Motility_related_protein_1 -LRB- MRP-1 / CD9 -RRB- expression : inverse correlation with metastases in breast_cancer .
22579611	0	CD9	83,86	OPG	50,53	CD9	OPG	12527(Tax:10090)	18383(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Bisphosphonate - and statin-induced enhancement of OPG expression and inhibition of CD9 , M-CSF , and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2 .
25890097	0	CD9	23,26	Sdf-1	0,5	CD9	Sdf-1	12527(Tax:10090)	20315(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- induces CD9 expression in stem cells engaged in muscle regeneration .
25890097	0	CD9	23,26	Sdf-1	0,5	CD9	Sdf-1	12527(Tax:10090)	20315(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- induces CD9 expression in stem cells engaged in muscle regeneration .
18247373	0	CD9	16,19	epidermal_growth_factor_receptor	30,62	CD9	epidermal growth factor receptor	928	1956	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The tetraspanin CD9 modulates epidermal_growth_factor_receptor signaling in cancer cells .
24246676	0	CD9	50,53	epidermal_growth_factor_receptor	70,102	CD9	epidermal growth factor receptor	928	1956	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing upregulation|nmod|cells regulated|nsubjpass|upregulation regulated|nmod|END_ENTITY	Pro-MMP-9 upregulation in HT1080 cells expressing CD9 is regulated by epidermal_growth_factor_receptor .
25760022	0	CD9	0,3	epidermal_growth_factor_receptor	60,92	CD9	epidermal growth factor receptor	928	1956	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|proliferation proliferation|nmod|cells cells|nmod|END_ENTITY	CD9 modulates proliferation of human glioblastoma cells via epidermal_growth_factor_receptor signaling .
10065872	0	CD9	0,3	integrin_alpha3	66,81	CD9	integrin alpha3	928	3675	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CD9 is expressed in extravillous trophoblasts in association with integrin_alpha3 and integrin_alpha5 .
23389628	0	CD9	12,15	junctional_adhesion_molecule-A	22,52	CD9	junctional adhesion molecule-A	928	50848	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Tetraspanin CD9 links junctional_adhesion_molecule-A to avb3 integrin to mediate basic_fibroblast_growth_factor-specific angiogenic signaling .
15476162	0	CD9	55,58	motility-related_protein-1	28,54	CD9	motility-related protein-1	928	928	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	-LSB- Differential expression of motility-related_protein-1 / CD9 gene in gastric_cancers and premalignant_lesions -RSB- .
8521390	0	CD9	42,45	motility_related_protein-1	8,34	CD9	motility related protein-1	928	928	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Reduced motility_related_protein-1 -LRB- MRP-1 / CD9 -RRB- gene expression as a factor of poor prognosis in non-small cell lung_cancer .
10557051	0	CD90	45,49	CD34	99,103	CD90	CD34	7070	947	Gene	Gene	aberrations|nmod|START_ENTITY Detection|nmod|aberrations Detection|dep|subfractions subfractions|appos|END_ENTITY	Detection of cytogenetic aberrations both in CD90 -LRB- Thy-1 -RRB- - positive and -LRB- Thy-1 -RRB- - negative stem cell -LRB- CD34 -RRB- subfractions of patients with acute and chronic_myeloid_leukemias .
11238132	0	CD90	92,96	CD34	87,91	CD90	CD34	7070	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Replicative stress after allogeneic bone marrow transplantation : changes in cycling of CD34 + CD90 + and CD34 + CD90 - hematopoietic progenitors .
11918561	0	CD90	6,10	CD34	0,4	CD90	CD34	7070	947	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ predict|nsubj|cells +|parataxis|predict +|compound|END_ENTITY	CD34 + / CD90 + cells infused best predict late haematopoietic reconstitution following autologous peripheral blood stem cell transplantation .
22155731	0	CD90	31,35	CD34	15,19	CD90	CD34	7070	947	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Synovial fluid CD34 CD44 CD90 mesenchymal stem cell levels are associated with the severity of primary_knee_osteoarthritis .
22981934	0	CD90	91,95	CD34	68,72	CD90	CD34	7070	947	Gene	Gene	preserve|dobj|START_ENTITY preserve|dobj|multipotentiality multipotentiality|nmod|CD38 CD38|compound|END_ENTITY	Notch signals contribute to preserve the multipotentiality of human CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- CD45RA -LRB- - -RRB- CD90 -LRB- + -RRB- hematopoietic progenitors by maintaining T cell lineage differentiation potential .
23129214	0	CD90	20,24	CD34	14,18	CD90	CD34	7070	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Human adipose CD34 + CD90 + stem cells and collagen scaffold constructs grafted in vivo fabricate loose connective and adipose tissues .
16962069	0	CD90	30,34	CD44	24,28	CD90	CD44	21838(Tax:10090)	12505(Tax:10090)	Gene	Gene	CNS|compound|START_ENTITY CNS|compound|END_ENTITY	Angiogenic potential of CD44 + CD90 + multipotent CNS stem cells in vitro .
21836053	0	CD90	53,57	CD44	47,51	CD90	CD44	7070	960	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Reconstruction of human elastic cartilage by a CD44 + CD90 + stem cell in the ear perichondrium .
22155731	0	CD90	31,35	CD44	23,27	CD90	CD44	7070	960	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Synovial fluid CD34 CD44 CD90 mesenchymal stem cell levels are associated with the severity of primary_knee_osteoarthritis .
18630512	7	CD90	1313,1317	CD56	1307,1311	CD56	CD45	4684	5788	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	All the NB BM samples -LRB- 15/15 -RRB- showed the CD45 - CD56 + CD90 + phenotype and 10/15 also showed CD57 positivity .
23957960	0	CD90	87,91	TCR	95,98	CD90	TCR	21838(Tax:10090)	328483(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells .
25536077	0	CD90	18,22	Thy-1	24,29	CD90	Thy-1	7070	7070	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of CD90 -LRB- Thy-1 -RRB- in Pancreatic_Adenocarcinoma Present in the Tumor Microenvironment .
17952444	0	CD90	14,18	Thy1	8,12	CD90	Thy1	7070	7070	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lack of Thy1 -LRB- CD90 -RRB- expression in neuroblastomas is correlated with impaired survival .
11248808	0	CD91	0,4	gp96	40,44	CD91	gp96	4035	7184	Gene	Gene	START_ENTITY|dep|receptor receptor|nmod|END_ENTITY	CD91 : a receptor for heat_shock protein gp96 .
11290339	0	CD91	0,4	gp96	50,54	CD91	gp96	4035	7184	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	CD91 is a common receptor for heat_shock proteins gp96 , hsp90 , hsp70 , and calreticulin .
21054788	0	CD91	0,4	mannan-binding_lectin	20,41	CD91	mannan-binding lectin	4035	4153	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CD91 interacts with mannan-binding_lectin -LRB- MBL -RRB- through the MBL-associated serine protease-binding site .
16673132	0	CD93	7,11	C1qRP	0,5	CD93	C1qRP	22918	22918	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	C1qRP -LRB- CD93 -RRB- expression on peripheral blood monocytes in patients with systemic_lupus_erythematosus .
18094537	0	CD93	12,16	C1qRp	18,23	CD93	C1qRp	22918	22918	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Decrease in CD93 -LRB- C1qRp -RRB- expression in a human monocyte-like cell line -LRB- U937 -RRB- treated with various apoptosis-inducing chemical substances .
15459234	0	CD93	0,4	GIPC	62,66	CD93	GIPC	22918	10755	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	CD93 interacts with the PDZ domain-containing adaptor protein GIPC : implications in the modulation of phagocytosis .
10848781	0	CD94	66,70	CD8	74,77	CD94	CD8	3824	925	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Increased expression of non-functional killer inhibitory receptor CD94 in CD8 + cells of myeloma patients .
15517612	0	CD94	11,15	CD8	105,108	CD94	CD8	3824	925	Gene	Gene	START_ENTITY|parataxis|expressed expressed|nmod|subsets subsets|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
15517612	0	CD94	37,41	CD8	105,108	CD94	CD8	3824	925	Gene	Gene	CD94|dep|START_ENTITY CD94|parataxis|expressed expressed|nmod|subsets subsets|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
10671222	0	CD94	72,76	NKG2-A	79,85	CD94	NKG2-A	3824	3821	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	CD69-triggered ERK activation and functions are negatively regulated by CD94 / NKG2-A inhibitory receptor .
9034158	0	CD94	21,25	NKG2A	0,5	CD94	NKG2A	3824	3821	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor .
15517612	0	CD94	11,15	TCR	110,113	CD94	TCR	3824	6962	Gene	Gene	START_ENTITY|parataxis|expressed expressed|nmod|subsets subsets|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
15517612	0	CD94	37,41	TCR	110,113	CD94	TCR	3824	6962	Gene	Gene	CD94|dep|START_ENTITY CD94|parataxis|expressed expressed|nmod|subsets subsets|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
12653481	0	CD94	137,141	heat_shock_protein_70	88,109	CD94	heat shock protein 70	16643(Tax:10090)	15511(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|dep|cells	Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat_shock_protein_70 -LRB- Hsp70 -RRB- - peptide-activated , CD94 positive natural killer cells .
8898964	0	CD94	0,4	natural_killer_cell_inhibitory_receptor	20,59	CD94	natural killer cell inhibitory receptor	3824	100132285	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	CD94 functions as a natural_killer_cell_inhibitory_receptor for different HLA class I alleles : identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies .
10910654	0	CD95	132,136	APO-1	121,126	CD95	APO-1	355	355	Gene	Gene	Fas|appos|START_ENTITY Fas|compound|END_ENTITY	-LSB- Apoptosis and hepatic cell proliferation in autoimmune_hepatitis and chronic_viral_hepatitis_C in children : analysis of APO-1 / Fas -LRB- CD95 -RRB- , bcl-2 and Ki67 expression -RSB- .
7528670	0	CD95	15,19	APO-1	4,9	CD95	APO-1	14102(Tax:10090)	14102(Tax:10090)	Gene	Gene	Fas|appos|START_ENTITY Fas|compound|END_ENTITY	The APO-1 / Fas -LRB- CD95 -RRB- receptor is expressed in homozygous MRL/lpr mice .
7539660	0	CD95	38,42	APO-1	27,32	CD95	APO-1	355	355	Gene	Gene	Fas|appos|START_ENTITY Fas|compound|END_ENTITY	Functional consequences of APO-1 / Fas -LRB- CD95 -RRB- antigen expression by normal and neoplastic hematopoietic cells .
7575348	0	CD95	34,38	APO-1	24,29	CD95	APO-1	355	355	Gene	Gene	Fas|appos|START_ENTITY Fas|compound|END_ENTITY	Molecular mechanisms of APO-1 / Fas -LRB- CD95 -RRB- - mediated apoptosis in tolerance and AIDS .
8688670	0	CD95	14,18	APO-1	20,25	CD95	APO-1	355	355	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Regulation of CD95 -LRB- APO-1 -RRB- expression and the induction of apoptosis in human T cells : changes in old age .
9288794	0	CD95	4,8	APO-1	10,15	CD95	APO-1	355	355	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	The CD95 -LRB- APO-1 / Fas -RRB- system mediates drug-induced apoptosis in neuroblastoma cells .
9163609	0	CD95	25,29	Apo-1	14,19	CD95	Apo-1	355	355	Gene	Gene	Fas|appos|START_ENTITY Fas|compound|END_ENTITY	Expression of Apo-1 / Fas -LRB- CD95 -RRB- , Bcl-2 , Bax and Bcl-x in myeloma cell lines : relationship between responsiveness to anti-Fas mab and p53 functional status .
9393960	0	CD95	100,104	Apo-1	89,94	CD95	Apo-1	355	355	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and characterization of polymorphisms in the promoter region of the human Apo-1 / Fas -LRB- CD95 -RRB- gene .
16179941	0	CD95	20,24	CAP3	12,16	CD95	CAP3	355	5272	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	The role of CAP3 in CD95 signaling : new insights into the mechanism of procaspase-8 activation .
11965496	0	CD95	30,34	CD178	46,51	CD95	CD178	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Genetic polymorphisms of Fas -LRB- CD95 -RRB- and FasL -LRB- CD178 -RRB- in human longevity : studies on centenarians .
16441482	0	CD95	14,18	CD178	30,35	CD95	CD178	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Study of Fas -LRB- CD95 -RRB- and FasL -LRB- CD178 -RRB- polymorphisms in liver transplant recipients .
21879377	0	CD95	42,46	CD178	58,63	CD95	CD178	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Evaluation of apoptosis-related gene Fas -LRB- CD95 -RRB- and FasL -LRB- CD178 -RRB- polymorphisms in Iranian rheumatoid_arthritis patients .
15972628	0	CD95	94,98	CD25	37,41	CD95	CD25	355	3559	Gene	Gene	susceptible|nmod|START_ENTITY +|ccomp|susceptible +|nsubj|FoxP3 FoxP3|compound|END_ENTITY	In contrast to effector T cells , CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand - but not to TCR-mediated cell death .
11972629	2	CD95	448,452	CD28	454,458	CD95	CD28	355	940	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	We aimed to elucidate the reconstitution of CD8 + T cells by separate analysis of putative na ve CD95 - CD28 + , memory CD95 + CD28 + and CD28 - T cell compartments after acute maximal depletion by high-dose_chemotherapy -LRB- HD-ChT -RRB- in women with high-risk breast_cancer .
9708185	0	CD95	33,37	CD28	19,23	CD95	CD28	355	940	Gene	Gene	Fas|appos|START_ENTITY END_ENTITY|nmod|Fas	Down-regulation of CD28 via Fas -LRB- CD95 -RRB- : influence of CD28 on T-cell apoptosis .
9708185	0	CD95	33,37	CD28	53,57	CD95	CD28	355	940	Gene	Gene	Fas|appos|START_ENTITY CD28|nmod|Fas Down-regulation|nmod|CD28 Down-regulation|dep|influence influence|nmod|END_ENTITY	Down-regulation of CD28 via Fas -LRB- CD95 -RRB- : influence of CD28 on T-cell apoptosis .
10505674	0	CD95	148,152	CD4	119,122	CD95	CD4	355	920	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	The cell death-inducing ability of glycoprotein 120 from different HIV strains correlates with their ability to induce CD4 lateral association with CD95 on CD4 + T cells .
10505674	0	CD95	148,152	CD4	156,159	CD95	CD4	355	920	Gene	Gene	association|nmod|START_ENTITY induce|dobj|association induce|nmod|cells cells|compound|END_ENTITY	The cell death-inducing ability of glycoprotein 120 from different HIV strains correlates with their ability to induce CD4 lateral association with CD95 on CD4 + T cells .
11122022	0	CD95	35,39	CD4	61,64	CD95	CD4	355	920	Gene	Gene	Fas|appos|START_ENTITY Fas|nmod|T T|compound|END_ENTITY	Decreased expression of Fas -LRB- APO-1 / CD95 -RRB- on peripheral blood CD4 + T lymphocytes in cutaneous_T-cell_lymphomas .
11122244	0	CD95	13,17	CD4	126,129	CD95	CD4	355	920	Gene	Gene	Induction|nmod|START_ENTITY ligand|nsubj|Induction ligand|nmod|apoptosis apoptosis|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Induction of CD95 ligand expression on T lymphocytes and B lymphocytes and its contribution to apoptosis of CD95-up-regulated CD4 + T lymphocytes in macaques by infection with a pathogenic simian/human _ immunodeficiency_virus .
11134499	0	CD95	0,4	CD4	37,40	CD95	CD4	355	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	CD95 -LRB- APO-1 / Fas -RRB- expression on naive CD4 -LRB- + -RRB- T cells increases with disease progression in HIV-infected children and adolescents : effect of highly active antiretroviral therapy -LRB- HAART -RRB- .
11272277	0	CD95	120,124	CD4	53,56	CD95	CD4	355	920	Gene	Gene	Fas|appos|START_ENTITY up-regulation|nmod|Fas apoptosis|nmod|up-regulation apoptosis|compound|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
11279310	0	CD95	36,40	CD4	45,48	CD95	CD4	355	920	Gene	Gene	APO-1|dep|START_ENTITY Fas|appos|APO-1 Fas|nmod|+ +|compound|END_ENTITY	Increased expression of Fas -LRB- APO-1 , CD95 -RRB- on CD4 + and CD8 + T lymphocytes during total_body_irradiation .
11859105	0	CD95	89,93	CD4	65,68	CD95	CD4	14102(Tax:10090)	12504(Tax:10090)	Gene	Gene	IL-4|compound|START_ENTITY expressing|dobj|IL-4 generates|xcomp|expressing generates|dobj|cells cells|compound|END_ENTITY	Administration of an antigen at a high dose generates regulatory CD4 + T cells expressing CD95 ligand and secreting IL-4 in the liver .
14739941	0	CD95	91,95	CD4	143,146	CD95	CD4	355	920	Gene	Gene	induced|nmod|START_ENTITY -2|acl|induced mediated|nsubj|-2 mediated|ccomp|lymphocytes lymphocytes|nsubj|apoptosis apoptosis|nmod|T T|compound|END_ENTITY	CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL -2 - induced susceptibility to CD95 -LRB- APO-1 / Fas -RRB- - mediated apoptosis of human resting CD4 -LRB- + -RRB- T lymphocytes .
15972628	0	CD95	94,98	CD4	33,36	CD95	CD4	355	920	Gene	Gene	susceptible|nmod|START_ENTITY +|ccomp|susceptible +|nsubj|FoxP3 FoxP3|compound|END_ENTITY	In contrast to effector T cells , CD4 + CD25 + FoxP3 + regulatory T cells are highly susceptible to CD95 ligand - but not to TCR-mediated cell death .
16767155	0	CD95	0,4	CD4	60,63	CD95	CD4	355	920	Gene	Gene	ligand|nsubj|START_ENTITY ligand|dobj|apoptosis apoptosis|nmod|thymic_lymphoma thymic_lymphoma|compound|END_ENTITY	CD95 ligand mediates T-cell_receptor-induced apoptosis of a CD4 + CD8 + double positive thymic_lymphoma .
18855225	0	CD95	32,36	CD4	48,51	CD95	CD4	355	920	Gene	Gene	levels|appos|START_ENTITY Fas|dobj|levels Fas|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Increased surface receptor Fas -LRB- CD95 -RRB- levels on CD4 + lymphocytes in patients with primary_intestinal_lymphangiectasia .
20181888	0	CD95	93,97	CD4	19,22	CD95	CD4	355	920	Gene	Gene	upregulation|compound|START_ENTITY blocking|dobj|upregulation protects|advcl|blocking protects|dobj|cells cells|nummod|END_ENTITY	Melatonin protects CD4 + T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation .
21052094	0	CD95	40,44	CD4	14,17	CD95	CD4	355	920	Gene	Gene	co-stimulation|compound|START_ENTITY activation|nmod|co-stimulation activation|nsubj|Modulation Modulation|nmod|T-cell T-cell|compound|END_ENTITY	Modulation of CD4 + T-cell activation by CD95 co-stimulation .
25411246	0	CD95	27,31	CD4	43,46	CD95	CD4	355	920	Gene	Gene	Protein|compound|START_ENTITY Protein|nmod|Cells Cells|compound|END_ENTITY	Interleukin 7 Up-regulates CD95 Protein on CD4 + T Cells by Affecting mRNA Alternative Splicing : PRIMING FOR A SYNERGISTIC EFFECT ON HIV-1 RESERVOIR MAINTENANCE .
26858545	0	CD95	12,16	CD4	52,55	CD95	CD4	355	920	Gene	Gene	expression|compound|START_ENTITY expression|acl|circulating circulating|dobj|lymphocytes lymphocytes|amod|END_ENTITY	Analysis of CD95 and CCR7 expression on circulating CD4 -LRB- + -RRB- lymphocytes revealed disparate immunoregulatory potentials in systemic_lupus_erythematosus .
7589104	0	CD95	122,126	CD4	71,74	CD95	CD4	14102(Tax:10090)	12504(Tax:10090)	Gene	Gene	_|compound|START_ENTITY deletion|nmod|_ deletion|nmod|CD8 CD8|compound|END_ENTITY	Clonal deletion of major histocompatibility complex class I-restricted CD4 + CD8 + thymocytes in vitro is independent of the CD95 -LRB- APO-1 / Fas -RRB- _ ligand .
8855300	0	CD95	5,9	CD4	66,69	CD95	CD4	355	920	Gene	Gene	expression|compound|START_ENTITY induced|nsubjpass|expression induced|nmod|cross-linking cross-linking|nummod|END_ENTITY	Fas -LRB- CD95 -RRB- expression and death-mediating function are induced by CD4 cross-linking on CD4 + T cells .
8855300	0	CD95	5,9	CD4	87,90	CD95	CD4	355	920	Gene	Gene	expression|compound|START_ENTITY induced|nsubjpass|expression induced|nmod|cross-linking cross-linking|nmod|cells cells|compound|END_ENTITY	Fas -LRB- CD95 -RRB- expression and death-mediating function are induced by CD4 cross-linking on CD4 + T cells .
9083895	0	CD95	106,110	CD4	102,105	CD95	CD4	355	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8 + CD95 + , CD8 + CD38 + , and CD4 + CD95 + T cells are markers for HIV-1_infection and clinical status .
9455798	0	CD95	75,79	CD4	0,3	CD95	CD4	355	920	Gene	Gene	mechanisms|appos|START_ENTITY kill|nmod|mechanisms kill|nsubj|cells cells|compound|END_ENTITY	CD4 T cells kill melanoma cells by mechanisms that are independent of Fas -LRB- CD95 -RRB- .
9596676	0	CD95	94,98	CD4	28,31	CD95	CD4	355	920	Gene	Gene	cells|appos|START_ENTITY efficacy|nmod|cells lymphocytes|nmod|efficacy lymphocytes|nsubj|sensitivity sensitivity|nmod|+ +|compound|END_ENTITY	Differential sensitivity of CD4 + and CD8 + T lymphocytes to the killing efficacy of Fas -LRB- Apo-1 / CD95 -RRB- ligand + tumor cells in B chronic_lymphocytic_leukemia .
10653855	0	CD95	119,123	CD8	107,110	CD95	CD8	355	925	Gene	Gene	Fas|appos|START_ENTITY Fas|compound|END_ENTITY	Soluble human MHC class I molecules induce soluble Fas_ligand secretion and trigger apoptosis in activated CD8 -LRB- + -RRB- Fas -LRB- CD95 -RRB- -LRB- + -RRB- T lymphocytes .
11165713	0	CD95	43,47	CD8	25,28	CD95	CD8	355	925	Gene	Gene	apoptosis|nummod|START_ENTITY protects|nmod|apoptosis protects|dobj|cells cells|nummod|END_ENTITY	TCR stimulation protects CD8 + T cells from CD95 mediated apoptosis .
16767155	0	CD95	0,4	CD8	65,68	CD95	CD8	355	925	Gene	Gene	ligand|nsubj|START_ENTITY ligand|dobj|apoptosis apoptosis|nmod|thymic_lymphoma thymic_lymphoma|compound|END_ENTITY	CD95 ligand mediates T-cell_receptor-induced apoptosis of a CD4 + CD8 + double positive thymic_lymphoma .
22615561	0	CD95	49,53	CD8	94,97	CD95	CD8	14102(Tax:10090)	925	Gene	Gene	accompany|amod|START_ENTITY accompany|dep|response response|compound|END_ENTITY	Pathogen-induced proapoptotic phenotype and high CD95 -LRB- Fas -RRB- expression accompany a suboptimal CD8 + T-cell response : reversal by adenoviral vaccine .
26586704	0	CD95	74,78	CD8	104,107	CD95	CD8	355	925	Gene	Gene	Perforin|nummod|START_ENTITY Expression|nmod|Perforin Associated|nmod|Expression Associated|nmod|Lymphocytes Lymphocytes|compound|END_ENTITY	Advanced Lung_Cancer Is Associated with Decreased Expression of Perforin , CD95 , CD38 by Circulating CD3 + CD8 + T Lymphocytes .
9083895	0	CD95	80,84	CD8	76,79	CD95	CD8	355	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Concentrations of soluble CD95 and CD8 antigens in the plasma and levels of CD8 + CD95 + , CD8 + CD38 + , and CD4 + CD95 + T cells are markers for HIV-1_infection and clinical status .
9759844	0	CD95	59,63	CD8	21,24	CD95	CD8	355	925	Gene	Gene	down-regulation|dep|START_ENTITY T|dobj|down-regulation T|nsubj|+ +|compound|END_ENTITY	Superantigen-driven , CD8 + T cell-mediated down-regulation : CD95 -LRB- Fas -RRB- - dependent down-regulation of human Ig responses despite CD95-independent killing of activated B cells .
24981893	0	CD95	28,32	CD80	62,66	CD95	CD80	355	941	Gene	Gene	Induction|nmod|START_ENTITY END_ENTITY|nsubj|Induction	Induction of death receptor CD95 and co-stimulatory molecules CD80 and CD86 by meningococcal capsular polysaccharide-loaded vaccine nanoparticles .
15786554	0	CD95	15,19	CD95	32,36	CD95	CD95	355	355	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Correlation of CD95 and soluble CD95 expression with acute_rejection status of liver transplantation .
15786554	0	CD95	32,36	CD95	15,19	CD95	CD95	355	355	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Correlation of CD95 and soluble CD95 expression with acute_rejection status of liver transplantation .
15870181	0	CD95	81,85	CD95	87,91	CD95	CD95	355	355	Gene	Gene	production|nmod|START_ENTITY production|dep|END_ENTITY	Haploinsufficiency , rather than the effect of an excessive production of soluble CD95 -LRB- CD95 -LCB- Delta -RCB- TM -RRB- , is the basis for ALPS_Ia in a family with duplicated 3 ' splice site AG in CD95 intron 5 on one allele .
15870181	0	CD95	87,91	CD95	81,85	CD95	CD95	355	355	Gene	Gene	production|dep|START_ENTITY production|nmod|END_ENTITY	Haploinsufficiency , rather than the effect of an excessive production of soluble CD95 -LRB- CD95 -LCB- Delta -RCB- TM -RRB- , is the basis for ALPS_Ia in a family with duplicated 3 ' splice site AG in CD95 intron 5 on one allele .
10563496	0	CD95	16,20	CD95L	32,37	CD95	CD95L	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Absence of Fas -LRB- CD95 -RRB- and FasL -LRB- CD95L -RRB- immunohistochemical expression suggests Fas/FasL-mediated apoptotic signal is not relevant in cutaneous Kaposi 's _ sarcoma lesions .
11272277	0	CD95	120,124	CD95L	138,143	CD95	CD95L	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
21042884	0	CD95	69,73	CD95L	91,96	CD95	CD95L	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Influence of levothyroxine treatment on serum levels of soluble Fas -LRB- CD95 -RRB- and Fas_Ligand -LRB- CD95L -RRB- in chronic autoimmune_hypothyroidism .
9761749	0	CD95	19,23	CD95L	35,40	CD95	CD95L	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Expression of Fas -LRB- CD95 -RRB- and FasL -LRB- CD95L -RRB- in human airway epithelium .
15109535	0	CD95	32,36	DR4/DR5	59,66	CD95	DR4/DR5	355	8797;8795	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Prognostic significance of Fas -LRB- CD95 -RRB- and TRAIL receptors -LRB- DR4/DR5 -RRB- expression in acute_myelogenous_leukemia .
22182753	0	CD95	0,4	EGFR	58,62	CD95	EGFR	355	1956	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	CD95 death receptor and epidermal_growth_factor_receptor -LRB- EGFR -RRB- in liver cell apoptosis and regeneration .
17245429	0	CD95	16,20	FLASH	0,5	CD95	FLASH	355	9994	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies .
10216102	0	CD95	83,87	FLICE	34,39	CD95	FLICE	355	841	Gene	Gene	interaction|compound|START_ENTITY absence|nmod|interaction END_ENTITY|nmod|absence	Anticancer drugs induce caspase-8 / FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction .
11464860	0	CD95	25,29	FasL	47,51	CD95	FasL	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Expression of Fas -LRB- APO-1 / CD95 -RRB- and Fas_ligand -LRB- FasL -RRB- in human neuroblastoma .
23152729	0	CD95	43,47	FasL	65,69	CD95	FasL	355	356	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Prognostic impact of apoptosis marker Fas -LRB- CD95 -RRB- and its ligand -LRB- FasL -RRB- on bladder_cancer in Egypt : study of the effect of schistosomiasis .
17301382	0	CD95	27,31	Fas_Antigen	14,25	CD95	Fas Antigen	355	355	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Fas_Antigen -LRB- CD95 -RRB- on Human Leukemic Cells and Assessment of Apoptosis on Fas + and Fas-Samples by Flowcytometry Method .
11596030	0	CD95	27,31	Fas_antigen	14,25	CD95	Fas antigen	355	355	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Fas_antigen -LRB- CD95 -RRB- in peripheral blood lymphocytes and in liver-infiltrating , cytotoxic lymphocytes in patients with hepatocellular_carcinoma .
7542501	0	CD95	38,42	Fas_antigen	25,36	CD95	Fas antigen	355	355	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Functional expression of Fas_antigen -LRB- CD95 -RRB- on hematopoietic progenitor cells .
11429161	0	CD95	75,79	Fas_ligand	63,73	CD95	Fas ligand	355	356	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|appos|ligand	Molecular cloning , characterization , and expression of porcine Fas_ligand -LRB- CD95 ligand -RRB- .
10477584	0	CD95	74,78	IFN-alpha	12,21	CD95	IFN-alpha	355	3439	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Recombinant IFN-alpha -LRB- 2b -RRB- increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells .
12368221	0	CD95	26,30	Interferon-gamma	0,16	CD95	Interferon-gamma	355	3458	Gene	Gene	augments|dobj|START_ENTITY augments|nsubj|END_ENTITY	Interferon-gamma augments CD95 -LRB- APO-1 / Fas -RRB- and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95-mediated apoptosis .
18498065	0	CD95	5,9	P53	0,3	CD95	P53	355	7157	Gene	Gene	pathways|compound|START_ENTITY END_ENTITY|appos|pathways	P53 , CD95 , cathepsin and survivin pathways in Fuchs ' _ dystrophy and pseudophakic_bullous_keratopathy corneas .
23729286	0	CD95	50,54	P53	34,37	CD95	P53	355	7157	Gene	Gene	FAS|appos|START_ENTITY FAS|compound|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
23729286	0	CD95	50,54	PTEN	39,43	CD95	PTEN	355	5728	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
12731064	0	CD95	31,35	TGF-beta1	0,9	CD95	TGF-beta1	355	7040	Gene	Gene	Fas|appos|START_ENTITY Fas|compound|END_ENTITY	TGF-beta1 modulates Fas -LRB- APO-1 / CD95 -RRB- - mediated apoptosis of human pre-B cell lines .
9521690	0	CD95	44,48	TNFR	99,103	CD95	TNFR	355	7132	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of the ligand binding site in Fas -LRB- CD95 -RRB- by site-directed mutagenesis and comparison with TNFR and CD40 .
11076296	0	CD95	78,82	bcl-2	71,76	CD95	bcl-2	355	596	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Cytomorphological differentiation diagnosis and evaluation of p53mut , bcl-2 , CD95 in peripheral B-cell small cell lymphomas -RSB- .
10089905	0	CD95	13,17	interferon-gamma	67,83	CD95	interferon-gamma	355	3458	Gene	Gene	Fas_antigen|appos|START_ENTITY induced|nsubjpass|Fas_antigen induced|nmod|END_ENTITY	Fas_antigen -LRB- CD95 -RRB- in pure erythroid cell line AS-E2 is induced by interferon-gamma and tumor_necrosis_factor-alpha and potentiates apoptotic death .
10227428	0	CD95	41,45	interferon-gamma	88,104	CD95	interferon-gamma	355	3458	Gene	Gene	enhances|dobj|START_ENTITY treatment|acl:relcl|enhances _|dep|treatment _|dep|cells cells|amod|END_ENTITY	Interferon _ -LRB- IFN -RRB- - beta treatment enhances CD95 and interleukin_10 expression but reduces interferon-gamma producing T cells in MS patients .
10516755	0	CD95	14,18	interferon-gamma	62,78	CD95	interferon-gamma	355	3458	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of CD95 expression and CD95-mediated cell death by interferon-gamma in acute_lymphoblastic_leukemia with chromosomal translocation t -LRB- 4 ; 11 -RRB- .
14872492	0	CD95	14,18	interferon-gamma	42,58	CD95	interferon-gamma	355	3458	Gene	Gene	apoptotic|nummod|START_ENTITY apoptotic|acl|signaling signaling|nmod|END_ENTITY	Inhibition of CD95 apoptotic signaling by interferon-gamma in human osteoarthritic chondrocytes is associated with increased expression of FLICE inhibitory protein .
9763578	0	CD95	11,15	interferon-gamma	52,68	CD95	interferon-gamma	355	3458	Gene	Gene	Fas/APO|appos|START_ENTITY Fas/APO|dep|apoptosis apoptosis|acl:relcl|activated activated|nmod|END_ENTITY	Fas/APO -1 -LRB- CD95 -RRB- - mediated apoptosis is activated by interferon-gamma and interferon - in interleukin-6 -LRB- IL-6 -RRB- - dependent and IL-6-independent multiple_myeloma cell lines .
9935158	0	CD95	14,18	interferon-gamma	92,108	CD95	interferon-gamma	355	3458	Gene	Gene	Regulation|nmod|START_ENTITY _|nsubj|Regulation _|nmod|END_ENTITY	Regulation of CD95 -LRB- Apo-1 / Fas -RRB- _ ligand and receptor expression in squamous-cell_carcinoma by interferon-gamma and cisplatin .
10697557	0	CD95	27,31	interleukin-2	10,23	CD95	interleukin-2	355	3558	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effect of interleukin-2 on CD95 -LRB- Fas/APO -1 -RRB- expression in fresh chronic_lymphocytic_leukaemia and mantle_cell_lymphoma cells : relationship to ex vivo chemoresponse .
11140882	0	CD95	49,53	interleukin-6	21,34	CD95	interleukin-6	355	3569	Gene	Gene	Fas|appos|START_ENTITY END_ENTITY|nmod|Fas	Effect of endogenous interleukin-6 on Fas -LRB- APO-1 / CD95 -RRB- receptor expression in advanced melanoma patients .
10027687	0	CD95	49,53	p53	30,33	CD95	p53	355	7157	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Apoptosis-associated proteins p53 and APO-1 / Fas -LRB- CD95 -RRB- in brains of adult patients with Down syndrome .
10327065	0	CD95	32,36	p53	110,113	CD95	p53	355	7157	Gene	Gene	involvement|nmod|START_ENTITY receptor/ligand|nsubj|involvement receptor/ligand|nmod|apoptosis apoptosis|acl|induced induced|nmod|transfer transfer|compound|END_ENTITY	Differential involvement of the CD95 -LRB- Fas/APO -1 -RRB- receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells .
10951571	0	CD95	61,65	p53	15,18	CD95	p53	14102(Tax:10090)	22060(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Involvement of p53 and interleukin_3 in the up-regulation of CD95 -LRB- APO-1 / Fas -RRB- by X-ray irradiation .
12118319	0	CD95	40,44	p53	59,62	CD95	p53	14102(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Tissue-specific regulation of Fas/APO -1 / CD95 expression by p53 .
12944915	0	CD95	43,47	p53	7,10	CD95	p53	355	7157	Gene	Gene	gene|compound|START_ENTITY repression|nmod|gene gain|dep|repression gain|compound|END_ENTITY	Mutant p53 gain of function : repression of CD95 -LRB- Fas/APO -1 -RRB- gene expression by tumor-associated p53 mutants .
12944915	0	CD95	43,47	p53	95,98	CD95	p53	355	7157	Gene	Gene	gene|compound|START_ENTITY repression|nmod|gene repression|acl|expression expression|nmod|mutants mutants|compound|END_ENTITY	Mutant p53 gain of function : repression of CD95 -LRB- Fas/APO -1 -RRB- gene expression by tumor-associated p53 mutants .
14612511	0	CD95	65,69	p53	8,11	CD95	p53	355	7157	Gene	Gene	expression|compound|START_ENTITY regulating|dobj|expression Role|advcl|regulating Role|nmod|END_ENTITY	Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells .
16611376	0	CD95	67,71	p53	50,53	CD95	p53	355	7157	Gene	Gene	Apo-1|dep|START_ENTITY Fas|appos|Apo-1 related|nsubj|Fas related|nmod|apoptosis apoptosis|nmod|END_ENTITY	In vitro folate_deficiency induces apoptosis by a p53 , Fas -LRB- Apo-1 , CD95 -RRB- independent , bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes .
9841917	0	CD95	18,22	p53	0,3	CD95	p53	355	7157	Gene	Gene	gene|compound|START_ENTITY activates|dobj|gene activates|nsubj|END_ENTITY	p53 activates the CD95 -LRB- APO-1 / Fas -RRB- gene in response to DNA damage by anticancer drugs .
11272277	0	CD95L	138,143	CD4	53,56	CD95L	CD4	356	920	Gene	Gene	Fas|appos|START_ENTITY up-regulation|nmod|Fas apoptosis|nmod|up-regulation apoptosis|compound|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
10563496	0	CD95L	32,37	CD95	16,20	CD95L	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Absence of Fas -LRB- CD95 -RRB- and FasL -LRB- CD95L -RRB- immunohistochemical expression suggests Fas/FasL-mediated apoptotic signal is not relevant in cutaneous Kaposi 's _ sarcoma lesions .
11272277	0	CD95L	138,143	CD95	120,124	CD95L	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
21042884	0	CD95L	91,96	CD95	69,73	CD95L	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Influence of levothyroxine treatment on serum levels of soluble Fas -LRB- CD95 -RRB- and Fas_Ligand -LRB- CD95L -RRB- in chronic autoimmune_hypothyroidism .
9761749	0	CD95L	35,40	CD95	19,23	CD95L	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Expression of Fas -LRB- CD95 -RRB- and FasL -LRB- CD95L -RRB- in human airway epithelium .
23821188	0	CD95L	31,36	FasL	25,29	CD95L	FasL	14103(Tax:10090)	14103(Tax:10090)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Age-dependent changes in FasL -LRB- CD95L -RRB- modulate macrophage function in a model of age-related macular_degeneration .
13679638	0	CD95L	73,78	Fas_ligand	61,71	CD95L	Fas ligand	14103(Tax:10090)	14103(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Modification of tumor cells with Fas -LRB- CD95 -RRB- antigen gene and Fas_ligand -LRB- CD95L -RRB- gene transfection by electroporation for immunotherapy of cancer .
23832418	0	CD95L	41,46	WT1	28,31	CD95L	WT1	356	7490	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	The Wilms ' _ tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic_T cells .
10200015	0	CD95L	35,40	fas_ligand	23,33	CD95L	fas ligand	356	356	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of fas_ligand -LRB- CD95L -RRB- on T cells after segmental allergen provocation in asthma .
9730890	0	CD95_ligand	28,39	FasL	41,45	CD95 ligand	FasL	356	356	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Antiinflammatory effects of CD95_ligand -LRB- FasL -RRB- - induced apoptosis .
9759866	0	CD95_ligand	48,59	NF-kappa_B	22,32	CD95 ligand	NF-kappa B	14103(Tax:10090)	18033(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|sites sites|amod|END_ENTITY	Identification of two NF-kappa_B sites in mouse CD95_ligand -LRB- Fas_ligand -RRB- promoter : functional analysis in T cell hybridoma .
17971293	0	CD96	29,33	CD155	62,67	CD96	CD155	84544(Tax:10090)	52118(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1 .
19056733	0	CD96	0,4	CD155	22,27	CD96	CD155	10225	5817	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains .
10903844	0	CD97	82,86	EMR2	6,10	CD97	EMR2	976	30817	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Human EMR2 , a novel EGF-TM7 molecule on chromosome 19p13 .1 , is closely related to CD97 .
10540231	0	CD97	37,41	decay-accelerating_factor	96,121	CD97	decay-accelerating factor	26364(Tax:10090)	13136(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating_factor -LRB- DAF , CD55 -RRB- .
9915839	0	CD98	5,9	4F2	0,3	CD98	4F2	17254(Tax:10090)	17254(Tax:10090)	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	4F2 -LRB- CD98 -RRB- heavy chain is associated covalently with an amino_acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer .
19068093	0	CD98	87,91	4F2_heavy_chain	70,85	CD98	4F2 heavy chain	8140	6520	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in early stage squamous cell carcinoma_of_the_lung .
19171406	0	CD98	87,91	4F2_heavy_chain	70,85	CD98	4F2 heavy chain	8140	6520	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of L-type amino_acid transporter 1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in stage I pulmonary adenocarcinoma .
22993604	0	CD98	87,91	4F2_heavy_chain	70,85	CD98	4F2 heavy chain	8140	6520	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of L-type_amino_acid_transporter_1 -LRB- LAT1 -RRB- and 4F2_heavy_chain -LRB- CD98 -RRB- expression in surgically resectable stage_III_non-small_cell_lung_cancer .
21750865	0	CD98	21,25	4F2hc	14,19	CD98	4F2hc	6520	6520	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of 4F2hc -LRB- CD98 -RRB- in pulmonary_neuroendocrine_tumors .
24503126	0	CD98	44,48	CD98	62,66	CD98	CD98	17254(Tax:10090)	17254(Tax:10090)	Gene	Gene	RNA|compound|START_ENTITY RNA|compound|END_ENTITY	Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice .
24503126	0	CD98	62,66	CD98	44,48	CD98	CD98	17254(Tax:10090)	17254(Tax:10090)	Gene	Gene	RNA|compound|START_ENTITY RNA|compound|END_ENTITY	Nanoparticles with surface antibody against CD98 and carrying CD98 small interfering RNA reduce colitis in mice .
26557810	0	CD99	14,18	AP-1	27,31	CD99	AP-1	4267	3726	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Engagement of CD99 Reduces AP-1 Activity by Inducing BATF in the Human Multiple Myeloma Cell Line RPMI8226 .
16314831	0	CD99	42,46	KCMF1	15,20	CD99	KCMF1	4267	56888	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing 's _ sarcoma cells .
9278313	0	CD99	0,4	LFA-1	26,31	CD99	LFA-1	4267	3683	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|adhesion adhesion|compound|END_ENTITY	CD99 -LRB- MIC2 -RRB- regulates the LFA-1 / ICAM-1-mediated adhesion of lymphocytes , and its gene encodes both positive and negative regulators of cellular adhesion .
11556754	0	CD99	138,142	MIC-2	144,149	CD99	MIC-2	4267	4267	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical detection of EWS and FLI-1 proteinss in Ewing_sarcoma and primitive_neuroectodermal_tumors : comparative analysis with CD99 -LRB- MIC-2 -RRB- expression .
10354133	0	CD99	0,4	MIC2	6,10	CD99	MIC2	4267	4267	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CD99 -LRB- MIC2 -RRB- expression in paediatric B-lineage leukaemia/lymphoma reflects maturation-associated patterns of normal B-lymphopoiesis .
10786814	0	CD99	26,30	MIC2	20,24	CD99	MIC2	4267	4267	Gene	Gene	Immunoreactivity|appos|START_ENTITY Immunoreactivity|nmod|END_ENTITY	Immunoreactivity of MIC2 -LRB- CD99 -RRB- in acute_myelogenous_leukemia and related_diseases .
11369656	0	CD99	0,4	Sp1	43,46	CD99	Sp1	4267	6667	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr_virus latent membrane protein 1 through nuclear factor-kappaB .
26619106	0	CD99	0,4	cyclin_D1	25,34	CD99	cyclin D1	4267	595	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	CD99 correlates with low cyclin_D1 , high topoisomerase 2 status and triple negative molecular phenotype but is prognostically irrelevant in breast_carcinoma .
71153	2	CDA	104,107	CDA	159,162	CDA	CDA	978	978	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of CDA and NPA by rheumatoid synovium and phagocytosis of CDA by synovial phagocytic cells .
71153	2	CDA	159,162	CDA	104,107	CDA	CDA	978	978	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of CDA and NPA by rheumatoid synovium and phagocytosis of CDA by synovial phagocytic cells .
20010457	0	CDA	88,91	cytidine_deaminase	63,81	CDA	cytidine deaminase	978	978	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High-resolution melting analysis of sequence variations in the cytidine_deaminase gene -LRB- CDA -RRB- in patients with cancer treated with gemcitabine .
23612254	0	CDA	64,67	cytidine_deaminase	44,62	CDA	cytidine deaminase	978	978	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Determination of common genetic variants in cytidine_deaminase -LRB- CDA -RRB- gene in Indian ethnic population .
24710090	0	CDA1	37,41	Cell_Division_Autoantigen_1	8,35	CDA1	Cell Division Autoantigen 1	64061	64061	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Cell_Division_Autoantigen_1 -LRB- CDA1 -RRB- in Cell Proliferation and Fibrosis .
19194796	0	CDC-2-like_kinase_1	70,89	CLK1	91,95	CDC-2-like kinase 1	CLK1	100141471(Tax:9823)	100141471(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , expression , and chromosomal mapping of the porcine CDC-2-like_kinase_1 -LRB- CLK1 -RRB- gene .
22615577	0	CDC-42	17,23	PAT-2	11,16	CDC-42	PAT-2	174233(Tax:6239)	176240(Tax:6239)	Gene	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling END_ENTITY|parataxis|required	Integrin a PAT-2 / CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis_elegans .
24632947	0	CDC-42	13,19	PAT-2	76,81	CDC-42	PAT-2	174233(Tax:6239)	176240(Tax:6239)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. _ elegans .
22570618	0	CDC-42	45,51	TIAM-1	28,34	CDC-42	TIAM-1	174233(Tax:6239)	259373(Tax:6239)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40 / DCC in neuronal protrusion and axon guidance .
18728180	0	CDC-48UFD-1	36,47	NPL-4	48,53	CDC-48UFD-1	NPL-4	851431(Tax:4932)	852468(Tax:4932)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Cell cycle progression requires the CDC-48UFD-1 / NPL-4 complex for efficient DNA replication .
12207228	0	CDC13	80,85	STM1	0,4	CDC13	STM1	851306(Tax:4932)	850843(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	STM1 , a gene which encodes a guanine quadruplex binding protein , interacts with CDC13 in Saccharomyces_cerevisiae .
19129509	0	CDC14B	0,6	FZR1	20,24	CDC14B	FZR1	218294(Tax:10090)	56371(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	CDC14B acts through FZR1 -LRB- CDH1 -RRB- to prevent meiotic maturation of mouse oocytes .
9405394	0	CDC16	52,57	PP5	33,36	CDC16	PP5	8881	5536	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27 , two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex .
7736578	0	CDC16Hs	25,32	CDC27Hs	0,7	CDC16Hs	CDC27Hs	8881	996	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition .
10766756	0	CDC2	36,40	Bcl-2	19,24	CDC2	Bcl-2	983	596	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Phosphorylation of Bcl-2 protein by CDC2 kinase during G2/M phases and its role in cell cycle regulation .
17108174	0	CDC2	21,25	Necdin	0,6	CDC2	Necdin	12534(Tax:10090)	17984(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Necdin downregulates CDC2 expression to attenuate neuronal apoptosis .
22094936	0	CDC2	21,25	miR-26a	5,12	CDC2	miR-26a	983	407015	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast_cancer .
23979597	0	CDC20	117,122	PHF8	39,43	CDC20	PHF8	107995(Tax:10090)	320595(Tax:10090)	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting_complex containing CDC20 .
17873905	0	CDC20	0,5	p53	73,76	CDC20	p53	991	7157	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	CDC20 , a potential cancer therapeutic target , is negatively regulated by p53 .
3301539	0	CDC24	33,38	CLS4	27,31	CDC24	CLS4	851190(Tax:4932)	851190(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Nucleotide sequence of the CLS4 -LRB- CDC24 -RRB- gene of Saccharomyces_cerevisiae .
26350460	0	CDC25	83,88	Phospholipase_C-epsilon	120,143	CDC25	Phospholipase C-epsilon	995	5334	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase_C-epsilon .
9632136	0	CDC25	91,96	Son-of-sevenless_1	122,140	CDC25	Son-of-sevenless 1	12532(Tax:10090)	20662(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless_1 -LRB- mSos1 -RRB- .
26350460	0	CDC25	83,88	Thrombin	0,8	CDC25	Thrombin	995	2147	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase_C-epsilon .
22467868	0	CDC25A	169,175	cell_division_cycle_25_homolog_A	135,167	CDC25A	cell division cycle 25 homolog A	993	993	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lin-28_homologue_A -LRB- LIN28A -RRB- promotes cell cycle progression via regulation of cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- , cyclin_D1 -LRB- CCND1 -RRB- , and cell_division_cycle_25_homolog_A -LRB- CDC25A -RRB- expression in cancer .
16082213	0	CDC25B	0,6	Aurora-A	26,34	CDC25B	Aurora-A	994	6790	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage .
17003105	0	CDC25B	20,26	CHK1	0,4	CDC25B	CHK1	994	1111	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage .
22982242	0	CDC25B	86,92	Selenoprotein_W	0,15	CDC25B	Selenoprotein W	994	6415	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Selenoprotein_W promotes cell cycle recovery from G2 arrest through the activation of CDC25B .
23840880	0	CDC25B	0,6	centrin_2	33,42	CDC25B	centrin 2	994	1069	Gene	Gene	stabilises|compound|START_ENTITY END_ENTITY|nsubj|stabilises	CDC25B overexpression stabilises centrin_2 and promotes the formation of excess centriolar foci .
7736578	0	CDC27Hs	0,7	CDC16Hs	25,32	CDC27Hs	CDC16Hs	996	8881	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition .
3018676	0	CDC28	65,70	CDC37	79,84	CDC28	CDC37	852457(Tax:4932)	851746(Tax:4932)	Gene	Gene	CDC36|nummod|START_ENTITY CDC36|nummod|END_ENTITY	Nucleotide sequence of the yeast cell division cycle start genes CDC28 , CDC36 , CDC37 , and CDC39 , and a structural analysis of the predicted products .
18606161	0	CDC2A	0,5	MSY2	41,45	CDC2A	MSY2	12534(Tax:10090)	53422(Tax:10090)	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	CDC2A -LRB- CDK1 -RRB- - mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation .
7565715	0	CDC34	29,34	UBC3	36,40	CDC34	UBC3	997	997	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Intragenic suppression among CDC34 -LRB- UBC3 -RRB- mutations defines a class of ubiquitin-conjugating catalytic domains .
7721857	0	CDC34	120,125	UBC3	127,131	CDC34	UBC3	851624(Tax:4932)	851624(Tax:4932)	Gene	Gene	enzyme|appos|START_ENTITY enzyme|appos|END_ENTITY	Increased ubiquitin expression suppresses the cell cycle defect associated with the yeast ubiquitin conjugating enzyme , CDC34 -LRB- UBC3 -RRB- .
3018676	0	CDC37	79,84	CDC28	65,70	CDC37	CDC28	851746(Tax:4932)	852457(Tax:4932)	Gene	Gene	CDC36|nummod|START_ENTITY CDC36|nummod|END_ENTITY	Nucleotide sequence of the yeast cell division cycle start genes CDC28 , CDC36 , CDC37 , and CDC39 , and a structural analysis of the predicted products .
8703009	0	CDC37	34,39	CDK4	45,49	CDC37	CDK4	11140	1019	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical interaction of mammalian CDC37 with CDK4 .
19420964	0	CDC4	25,29	FBXW7	31,36	CDC4	FBXW7	55294	55294	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Somatic mutations of the CDC4 -LRB- FBXW7 -RRB- gene in hereditary colorectal_tumors .
10891456	0	CDC42	89,94	CD47	28,32	CDC42	CD47	998	961	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Integrin-associated_protein / CD47 regulates motile activity in human B-cell lines through CDC42 .
26566162	0	CDC42	79,84	MicroRNA-137	0,12	CDC42	MicroRNA-137	998	406928	Gene	Gene	Apoptosis|dep|START_ENTITY Apoptosis|compound|END_ENTITY	MicroRNA-137 Negatively Regulates H2O2-Induced Cardiomyocyte Apoptosis Through CDC42 .
10995436	0	CDC42	34,39	N-WASP	13,19	CDC42	N-WASP	379055(Tax:8355)	431898(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of N-WASP activation by CDC42 and phosphatidylinositol_4 , _ 5-bisphosphate .
26051942	0	CDC42	15,20	NRP1	0,4	CDC42	NRP1	12540(Tax:10090)	18186(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells .
11726672	0	CDC42	145,150	Rac-1	166,171	CDC42	Rac-1	998	5879	Gene	Gene	subunits|appos|START_ENTITY proteins|appos|subunits proteins|nmod|END_ENTITY	Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins , beta gamma subunits , small GTPase CDC42 , and partly by Rac-1 .
20530489	0	CDC42	96,101	Tuberous_sclerosis_complex_2	0,28	CDC42	Tuberous sclerosis complex 2	998	7249	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Tuberous_sclerosis_complex_2 -LRB- TSC2 -RRB- regulates cell migration and polarity through activation of CDC42 and RAC1 .
18723021	0	CDC45	61,66	BRCA2	16,21	CDC45	BRCA2	8318	675	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	A kinetoplastid BRCA2 interacts with DNA replication protein CDC45 .
22549779	0	CDC48	43,48	cell_division_cycle_48	19,41	CDC48	cell division cycle 48	327197(Tax:7955)	327197(Tax:7955)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Protective role of cell_division_cycle_48 -LRB- CDC48 -RRB- protein against neurodegeneration_via_ubiquitin-proteasome_system_dysfunction during zebrafish development .
21454556	0	CDC50A	34,40	P4-ATPase_ATP8A2	139,155	CDC50A	P4-ATPase ATP8A2	55754	201780	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of the beta-subunit CDC50A in the stable expression , assembly , subcellular localization , and lipid transport activity of the P4-ATPase_ATP8A2 .
16227198	0	CDC55	20,25	YND1	0,4	CDC55	YND1	852685(Tax:4932)	856722(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity .
20048340	0	CDC6	0,4	ATR	22,25	CDC6	ATR	403388(Tax:8355)	398197(Tax:8355)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells .
9889196	0	CDC6	29,33	CDK2	46,50	CDC6	CDK2	990	1017	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphorylation of mammalian CDC6 by cyclin_A / CDK2 regulates its subcellular localization .
22871742	0	CDC6	0,4	GATA1	70,75	CDC6	GATA1	990	2623	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	CDC6 expression is regulated by lineage-specific transcription factor GATA1 .
9889196	0	CDC6	29,33	cyclin_A	37,45	CDC6	cyclin A	990	890	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of mammalian CDC6 by cyclin_A / CDK2 regulates its subcellular localization .
19054765	0	CDC7	27,31	CDT1	6,10	CDC7	CDT1	8317	81620	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase .
22021426	0	CDC73	21,26	RNF20	67,72	CDC73	RNF20	79577	56254	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination .
25275584	0	CDCP1	0,5	CD146	19,24	CDCP1	CD146	64866	4162	Gene	Gene	identifies|nsubj|START_ENTITY identifies|dobj|subset subset|compound|END_ENTITY	CDCP1 identifies a CD146 negative subset of marrow fibroblasts involved with cytokine production .
19077003	0	CDCP1	45,50	CUB_domain_containing_protein	14,43	CDCP1	CUB domain containing protein	64866	64866	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CUB_domain_containing_protein -LRB- CDCP1 -RRB- is correlated with prognosis and survival of patients with adenocarcinoma_of_lung .
17335815	0	CDCP1	51,56	CUB_domain_containing_protein_1	18,49	CDCP1	CUB domain containing protein 1	64866	64866	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the CUB_domain_containing_protein_1 -LRB- CDCP1 -RRB- gene in colorectal_tumour cells .
26307391	0	CDCP1	17,22	HIF-2a	0,6	CDCP1	HIF-2a	64866	2034	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	HIF-2a regulates CDCP1 to promote PKC - mediated migration_in_hepatocellular_carcinoma .
17224448	0	CDCrel-1	37,45	Sept5	30,35	CDCrel-1	Sept5	18951(Tax:10090)	18951(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of adult type Sept5 -LRB- CDCrel-1 -RRB- by cyclin-dependent_kinase_5 inhibits interaction with syntaxin-1 .
22535324	0	CDH1	0,4	CDH1	32,36	CDH1	CDH1	999	999	Gene	Gene	levels|nummod|START_ENTITY levels|compound|END_ENTITY	CDH1 gene polymorphisms , plasma CDH1 levels and risk of gastric_cancer in a Chinese population .
22535324	0	CDH1	32,36	CDH1	0,4	CDH1	CDH1	999	999	Gene	Gene	levels|compound|START_ENTITY levels|nummod|END_ENTITY	CDH1 gene polymorphisms , plasma CDH1 levels and risk of gastric_cancer in a Chinese population .
21596315	0	CDH1	60,64	CDK2	37,41	CDH1	CDK2	999	1017	Gene	Gene	antagonize|dobj|START_ENTITY activated|xcomp|antagonize activated|nmod|END_ENTITY	Deubiquitinase USP37 is activated by CDK2 to antagonize APC -LRB- CDH1 -RRB- and promote S phase entry .
26511190	0	CDH1	24,28	E-CADHERIN	0,10	CDH1	E-CADHERIN	999	999	Gene	Gene	GENE|appos|START_ENTITY GENE|compound|END_ENTITY	E-CADHERIN CODING GENE -LRB- CDH1 -RRB- AND NONSYNDROMIC CLEFT LIP WITH OR WITHOUT CLEFT PALATE : IS THERE ANY ASSOCIATION ?
20353702	0	CDH1	67,71	E-Cadherin	73,83	CDH1	E-Cadherin	999	999	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	-LSB- Gastric_carcinoma and chronic_gastritis : epigenetic regulation of CDH1 -LRB- E-Cadherin -RRB- , CDKN2A -LRB- p16INK4A -RRB- , PTGS2 -LRB- COX-2 -RRB- and EGFR genes through methylation -RSB- .
10072428	0	CDH1	26,30	E-cadherin	9,19	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Germline E-cadherin gene -LRB- CDH1 -RRB- mutations predispose to familial gastric_cancer and colorectal_cancer .
10896919	0	CDH1	21,25	E-cadherin	4,14	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The E-cadherin gene -LRB- CDH1 -RRB- variants T340A and L599V in gastric and colorectal_cancer patients in Korea .
11313896	0	CDH1	17,21	E-cadherin	0,10	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	E-cadherin gene -LRB- CDH1 -RRB- promoter methylation as the second hit in sporadic_diffuse_gastric_carcinoma .
11996968	0	CDH1	62,66	E-cadherin	45,55	CDH1	E-cadherin	999	999	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Characterization of DNA polymorphisms in the E-cadherin gene -LRB- CDH1 -RRB- promoter region .
12203775	0	CDH1	43,47	E-cadherin	26,36	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic control of the E-cadherin gene -LRB- CDH1 -RRB- by CpG methylation in colectomy samples of patients with ulcerative_colitis .
12579297	0	CDH1	34,38	E-cadherin	22,32	CDH1	E-cadherin	999	999	Gene	Gene	control|appos|START_ENTITY control|nmod|END_ENTITY	Epigenetic control of E-cadherin -LRB- CDH1 -RRB- by CpG methylation in metastasising laryngeal_cancer .
12604719	0	CDH1	58,62	E-cadherin	41,51	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ile-Leu substitution -LRB- I415L -RRB- in germline E-cadherin gene -LRB- CDH1 -RRB- in Japanese familial gastric_cancer .
12629411	0	CDH1	35,39	E-cadherin	23,33	CDH1	E-cadherin	999	999	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Hypermethylation of an E-cadherin -LRB- CDH1 -RRB- promoter region in high grade transitional cell carcinoma_of_the_bladder comprising carcinoma in situ .
14610318	0	CDH1	72,76	E-cadherin	55,65	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The G/A nucleotide change at cDNA position 2494 in the E-cadherin gene -LRB- CDH1 -RRB- : analysis in Italian patients .
14630673	0	CDH1	33,37	E-cadherin	16,26	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of the E-cadherin gene -LRB- CDH1 -RRB- in diffuse gastric_cancer susceptibility : from the laboratory to clinical practice .
16934975	0	CDH1	33,37	E-cadherin	21,31	CDH1	E-cadherin	999	999	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Polymorphisms in the E-cadherin -LRB- CDH1 -RRB- gene promoter and the risk of bladder_cancer .
17221870	0	CDH1	74,78	E-cadherin	62,72	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of seven novel germline mutations in the human E-cadherin -LRB- CDH1 -RRB- gene .
19398441	0	CDH1	29,33	E-cadherin	17,27	CDH1	E-cadherin	999	999	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms in E-cadherin -LRB- CDH1 -RRB- result in a mis-localised cytoplasmic protein that is associated with Crohn 's _ disease .
19781162	0	CDH1	34,38	E-cadherin	17,27	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Associations of E-cadherin gene -LRB- CDH1 -RRB- and hereditary_gastric_cancer in China -RSB- .
20632448	0	CDH1	27,31	E-cadherin	15,25	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of E-cadherin -LRB- CDH1 -RRB- gene polymorphisms and gastric_cancer risk .
21462191	0	CDH1	23,27	E-cadherin	11,21	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effects of E-cadherin -LRB- CDH1 -RRB- gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular_carcinoma .
21472888	0	CDH1	23,27	E-cadherin	11,21	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effects of E-cadherin -LRB- CDH1 -RRB- gene promoter polymorphisms on the risk and clinicopathologic development of oral_cancer .
21997289	0	CDH1	12,16	E-cadherin	0,10	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	E-cadherin -LRB- CDH1 -RRB- gene promoter polymorphism and the risk of colorectal_cancer : a meta-analysis .
22194161	0	CDH1	32,36	E-cadherin	20,30	CDH1	E-cadherin	999	999	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between E-cadherin -LRB- CDH1 -RRB- polymorphisms and papillary_thyroid_carcinoma risk in Han Chinese population .
25124632	0	CDH1	51,55	E-cadherin	57,67	CDH1	E-cadherin	999	999	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Loss of expression and aberrant methylation of the CDH1 -LRB- E-cadherin -RRB- gene in breast_cancer patients from Kashmir .
26191293	0	CDH1	32,36	E-cadherin	20,30	CDH1	E-cadherin	999	999	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between E-cadherin -LRB- CDH1 -RRB- polymorphisms and pancreatic_cancer risk in Han Chinese population .
26742007	0	CDH1	8,12	E-cadherin	14,24	CDH1	E-cadherin	999	999	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of CDH1 -LRB- E-cadherin -RRB- expression is associated with infiltrative tumour growth and lymph node metastasis .
9744472	0	CDH1	35,39	E-cadherin	23,33	CDH1	E-cadherin	999	999	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations of the human E-cadherin -LRB- CDH1 -RRB- gene .
23954296	0	CDH1	30,34	Sal-like_4	0,10	CDH1	Sal-like 4	999	57167	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Sal-like_4 -LRB- SALL4 -RRB- suppresses CDH1 expression and maintains cell dispersion in basal-like breast_cancer .
23069940	0	CDH13	39,44	BRN2	0,4	CDH13	BRN2	1012	5454	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	BRN2 is a transcriptional repressor of CDH13 -LRB- T-cadherin -RRB- in melanoma cells .
10737605	0	CDH13	26,31	T-cadherin	14,24	CDH13	T-cadherin	1012	1012	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of T-cadherin -LRB- CDH13 , H-Cadherin -RRB- in human brain and its characteristics as a negative growth regulator of epidermal_growth_factor in neuroblastoma cells .
11355171	0	CDH13	12,17	T-cadherin	0,10	CDH13	T-cadherin	1012	1012	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	T-cadherin -LRB- CDH13 , H-cadherin -RRB- expression downregulated surfactant_protein_D in bronchioloalveolar cells .
12177241	0	CDH13	20,25	T-cadherin	8,18	CDH13	T-cadherin	1012	1012	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of T-cadherin -LRB- CDH13 , H-cadherin -RRB- expression in cutaneous_squamous_cell_carcinoma .
21872196	0	CDH13	26,31	adiponectin	32,43	CDH13	adiponectin	1012	9370	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A variant upstream of the CDH13 adiponectin receptor gene and metabolic_syndrome in Swedes .
24041676	0	CDH13	0,5	adiponectin	62,73	CDH13	adiponectin	1012	9370	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	CDH13 genotype-dependent association of high-molecular weight adiponectin with all-cause mortality : the J-SHIPP study .
18348277	0	CDH23	52,57	cadherin_23	39,50	CDH23	cadherin 23	64072	64072	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms in the cadherin_23 -LRB- CDH23 -RRB- gene in Polish workers exposed to industrial noise .
20385540	0	CDH3	146,150	C/EBPbeta	133,142	CDH3	C/EBPbeta	1001	1051	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	ICI_182 ,780 induces P-cadherin overexpression in breast_cancer cells through chromatin remodelling at the promoter level : a role for C/EBPbeta in CDH3 gene activation .
20216405	0	CDK-2	27,32	Cyclin-dependent_kinase_2	0,25	CDK-2	Cyclin-dependent kinase 2	1017	1017	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclin-dependent_kinase_2 -LRB- CDK-2 -RRB- expression in nonmelanocytic human cutaneous lesions .
25694605	0	CDK-5	30,35	p35	18,21	CDK-5	p35	1020	8851	Gene	Gene	localization|compound|START_ENTITY localization|amod|END_ENTITY	HSV-1 upregulates p35 , alters CDK-5 localization , and stimulates CDK-5 kinase activity during acute_infection in neurons .
23806693	0	CDK-associated_Cullin_1	0,23	ERK1/2	71,77	CDK-associated Cullin 1	ERK1/2	143384	5595;5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	CDK-associated_Cullin_1 promotes cell proliferation with activation of ERK1/2 in human lung_cancer A549 cells .
22797303	0	CDK1	10,14	C/EBPa	86,92	CDK1	C/EBPa	983	1050	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Targeting CDK1 promotes FLT3-activated acute_myeloid_leukemia differentiation through C/EBPa .
17172867	0	CDK1	22,26	Cdc25A	46,52	CDK1	Cdc25A	983	993	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320 .
24189531	0	CDK1	0,4	HIF-1a	16,22	CDK1	HIF-1a	983	3091	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	CDK1 stabilizes HIF-1a via direct phosphorylation of Ser668 to promote tumor growth .
23921553	0	CDK1	24,28	NuMA	0,4	CDK1	NuMA	983	4926	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function .
23602554	0	CDK1	39,43	SAMHD1	19,25	CDK1	SAMHD1	983	25939	Gene	Gene	regulates|nsubj|START_ENTITY Phosphorylation|parataxis|regulates Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
23602554	0	CDK1	39,43	SAMHD1	19,25	CDK1	SAMHD1	983	25939	Gene	Gene	regulates|nsubj|START_ENTITY Phosphorylation|parataxis|regulates Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
24101154	0	CDK1	0,4	YAP	24,27	CDK1	YAP	983	10413	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	CDK1 phosphorylation of YAP promotes mitotic_defects and cell motility and is essential for neoplastic transformation .
26506418	0	CDK1	41,45	ZFAS1	20,25	CDK1	ZFAS1	983	441951	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal_cancer .
11161389	0	CDK1	41,45	cyclin-dependent_kinase_1	14,39	CDK1	cyclin-dependent kinase 1	983	983	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- by indirubin derivatives in human tumour cells .
17981370	0	CDK1	101,105	cyclin-dependent_kinase_1	74,99	CDK1	cyclin-dependent kinase 1	983	983	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Novel 9-oxo-thiazolo -LSB- 5,4-f -RSB- quinazoline-2-carbonitrile derivatives as dual cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- / glycogen synthase kinase-3 -LRB- GSK-3 -RRB- inhibitors : synthesis , biological evaluation and molecular modeling studies .
23602554	0	CDK1	39,43	cyclin_A2	29,38	CDK1	cyclin A2	983	890	Gene	Gene	regulates|nsubj|START_ENTITY Phosphorylation|parataxis|regulates Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
23602554	0	CDK1	39,43	cyclin_A2	29,38	CDK1	cyclin A2	983	890	Gene	Gene	regulates|nsubj|START_ENTITY Phosphorylation|parataxis|regulates Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
11139145	0	CDK1	66,70	cyclin_B1	25,34	CDK1	cyclin B1	54237(Tax:10116)	25203(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Developmental changes in cyclin_B1 and cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- levels in the different populations of spermatogenic cells of the post-natal rat testis .
21051949	0	CDK1	43,47	cyclin_B1	33,42	CDK1	cyclin B1	983	891	Gene	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	FGF inhibits the activity of the cyclin_B1 / CDK1 kinase to induce a transient G arrest in RCS chondrocytes .
16870444	0	CDK1	82,86	cyclin_dependent_kinase_1	55,80	CDK1	cyclin dependent kinase 1	983	983	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis of 2-amino-4 - -LRB- 7-azaindol-3-yl -RRB- pyrimidines as cyclin_dependent_kinase_1 -LRB- CDK1 -RRB- inhibitors .
17234412	0	CDK1	117,121	cyclin_dependent_kinase_1	90,115	CDK1	cyclin dependent kinase 1	983	983	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Synthesis of 3 - -LRB- 1H-benzimidazol-2-yl -RRB- -5 - isoquinolin-4-ylpyrazolo -LSB- 1,2-b -RSB- pyridine , a potent cyclin_dependent_kinase_1 -LRB- CDK1 -RRB- inhibitor .
18232654	0	CDK1	65,69	cyclin_dependent_kinase_1	38,63	CDK1	cyclin dependent kinase 1	983	983	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Pyrrolo -LSB- 2,3-a -RSB- carbazoles as potential cyclin_dependent_kinase_1 -LRB- CDK1 -RRB- Inhibitors .
19398314	0	CDK1/2	65,71	cyclin-dependent_kinase	40,63	CDK1/2	cyclin-dependent kinase	69131;12534;12566	69131(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	WITHDRAWN : A publisher 's note to `` Novel cyclin-dependent_kinase -LRB- CDK1/2 -RRB- inhibitor induced retinopathy in CD1 and B6C3F1 mice '' This article has been withdrawn at the request of the author -LRB- s -RRB- and/or editor .
22298115	0	CDK10	43,48	cyclin-dependent_kinase_10	15,41	CDK10	cyclin-dependent kinase 10	8558	8558	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of the cyclin-dependent_kinase_10 -LRB- CDK10 -RRB- on the tamoxifen sensitivity of keloid samples .
15792358	0	CDK11	30,35	p58	36,39	CDK11	p58	12537(Tax:10090)	12537(Tax:10090)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Protein expression pattern of CDK11 -LRB- p58 -RRB- during testicular development in the mouse .
23703121	0	CDK11	86,91	p58	92,95	CDK11	p58	252879(Tax:10116)	301323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11 -LRB- p58 -RRB- expression in PC12 cells through downregulating AKT pathway .
26470709	0	CDK11	17,22	p58	23,26	CDK11	p58	984	984	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of CDK11 -LRB- p58 -RRB- in human breast_cancer growth and angiogenesis .
26885618	0	CDK11p58	31,39	GADD45a	0,7	CDK11p58	GADD45a	984	1647	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	GADD45a and y interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migration .
25576733	0	CDK11p58	16,24	Hepsin	0,6	CDK11p58	Hepsin	984	3249	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Hepsin inhibits CDK11p58 I.E. activity by suppressing unr expression and eIF-2a phosphorylation in prostate_cancer .
26305884	0	CDK16	38,43	CCNYL1	0,6	CDK16	CCNYL1	18555(Tax:10090)	227210(Tax:10090)	Gene	Gene	Cooperates|nmod|START_ENTITY Cooperates|nsubj|END_ENTITY	CCNYL1 , but Not CCNY , Cooperates with CDK16 to Regulate Spermatogenesis in Mouse .
26305884	0	CDK16	38,43	CCNYL1	0,6	CDK16	CCNYL1	18555(Tax:10090)	227210(Tax:10090)	Gene	Gene	Cooperates|nmod|START_ENTITY Cooperates|nsubj|END_ENTITY	CCNYL1 , but Not CCNY , Cooperates with CDK16 to Regulate Spermatogenesis in Mouse .
9889196	0	CDK2	46,50	CDC6	29,33	CDK2	CDC6	1017	990	Gene	Gene	regulates|nsubj|START_ENTITY Phosphorylation|parataxis|regulates Phosphorylation|nmod|END_ENTITY	Phosphorylation of mammalian CDC6 by cyclin_A / CDK2 regulates its subcellular localization .
23316279	0	CDK2	33,37	CSN5	0,4	CDK2	CSN5	1017	10987	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner .
10626899	0	CDK2	9,13	Cyclin_A	0,8	CDK2	Cyclin A	1017	890	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Cyclin_A / CDK2 regulates V -LRB- D -RRB- J recombination by coordinating RAG-2 accumulation and DNA repair .
25736292	0	CDK2	9,13	Cyclin_A	0,8	CDK2	Cyclin A	1017	890	Gene	Gene	phosphorylation|nummod|START_ENTITY replisome|nsubj|phosphorylation END_ENTITY|parataxis|replisome	Cyclin_A / CDK2 phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication .
7969176	0	CDK2	9,13	Cyclin_A	0,8	CDK2	Cyclin A	1017	890	Gene	Gene	binds|nsubj|START_ENTITY END_ENTITY|parataxis|binds	Cyclin_A / CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1 / DP-1 by phosphorylation .
7969176	0	CDK2	9,13	E2F-1	32,37	CDK2	E2F-1	1017	1869	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Cyclin_A / CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1 / DP-1 by phosphorylation .
24780297	0	CDK2	47,51	Hexokinase_2	0,12	CDK2	Hexokinase 2	1017	3099	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Hexokinase_2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts .
16760655	0	CDK2	0,4	MYC	20,23	CDK2	MYC	1017	4609	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	CDK2 is required by MYC to induce apoptosis .
22231403	0	CDK2	78,82	Mre11	0,5	CDK2	Mre11	1017	4361	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2 .
23095674	0	CDK2	60,64	PARP1	79,84	CDK2	PARP1	1017	142	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	PARty promoters : hormone-dependent gene regulation requires CDK2 activation of PARP1 .
17635516	0	CDK2	0,4	PI3K	24,28	CDK2	PI3K	362817(Tax:10116)	298947(Tax:10116)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes .
23390529	0	CDK2	52,56	Pin1	21,25	CDK2	Pin1	1017	5300	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen_receptor_a in breast_cancer .
25015816	0	CDK2	73,77	SAMHD1	97,103	CDK2	SAMHD1	1017	25939	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells .
25015816	0	CDK2	73,77	SAMHD1	97,103	CDK2	SAMHD1	1017	25939	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells .
19201832	0	CDK2	0,4	Smad2	24,29	CDK2	Smad2	1017	4087	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone_marrow_myeloma cells .
21596315	0	CDK2	37,41	USP37	15,20	CDK2	USP37	1017	57695	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Deubiquitinase USP37 is activated by CDK2 to antagonize APC -LRB- CDH1 -RRB- and promote S phase entry .
22447046	0	CDK2	35,39	Zbtb7	101,106	CDK2	Zbtb7	1017	51341	Gene	Gene	expression|nmod|START_ENTITY expression|dep|implications implications|nmod|role role|nmod|END_ENTITY	Zbtb7 suppresses the expression of CDK2 and E2F4 in liver_cancer cells : implications for the role of Zbtb7 in cell cycle regulation .
19323453	0	CDK2	110,114	cyclin-dependent_kinase_2	83,108	CDK2	cyclin-dependent kinase 2	1017	1017	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Insights into the structural basis of N2 and O6 substituted guanine derivatives as cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- inhibitors : prediction of the binding modes and potency of the inhibitors by docking and ONIOM calculations .
20869873	0	CDK2	102,106	cyclin-dependent_kinase_2	75,100	CDK2	cyclin-dependent kinase 2	1017	1017	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	3D-QSAR and docking studies on pyrazolo -LSB- 4,3-h -RSB- qinazoline-3-carboxamides as cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- inhibitors .
22331465	0	CDK2	35,39	cyclin-dependent_kinase_2	8,33	CDK2	cyclin-dependent kinase 2	12566(Tax:10090)	12566(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Loss of cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication .
14572899	0	CDK2	106,110	cyclin_A	19,27	CDK2	cyclin A	1017	890	Gene	Gene	region|compound|START_ENTITY requires|dobj|region requires|nsubj|association association|nmod|p21 p21|compound|END_ENTITY	The association of cyclin_A and cyclin kinase inhibitor p21 in response to gamma-irradiation requires the CDK2 binding region , but not the Cy motif .
14699150	0	CDK2	126,130	cyclin_A	104,112	CDK2	cyclin A	12566(Tax:10090)	12428(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene : induction of cyclin_A and enhanced CDK2 activity .
9889196	0	CDK2	46,50	cyclin_A	37,45	CDK2	cyclin A	1017	890	Gene	Gene	regulates|nsubj|START_ENTITY Phosphorylation|parataxis|regulates Phosphorylation|nmod|END_ENTITY	Phosphorylation of mammalian CDC6 by cyclin_A / CDK2 regulates its subcellular localization .
22713240	0	CDK2	27,31	cyclin_E	18,26	CDK2	cyclin E	362817(Tax:10116)	25729(Tax:10116)	Gene	Gene	complexes|compound|START_ENTITY overcomes|nsubj|complexes Overexpression|parataxis|overcomes Overexpression|nmod|END_ENTITY	Overexpression of cyclin_E / CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins .
11591175	0	CDK2	29,33	p21	0,3	CDK2	p21	1017	1026	Gene	Gene	protein|compound|START_ENTITY associated|nmod|protein associated|nsubjpass|END_ENTITY	p21 -LRB- WAF1 -RRB- is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment .
12706118	0	CDK2	47,51	p21	109,112	CDK2	p21	1017	1026	Gene	Gene	activity|compound|START_ENTITY growth_arrest|nmod|activity delay|dobj|growth_arrest delay|advcl|senescing senescing|advcl|reducing reducing|dobj|expression expression|amod|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
14572899	0	CDK2	106,110	p21	56,59	CDK2	p21	1017	1026	Gene	Gene	region|compound|START_ENTITY requires|dobj|region requires|nsubj|association association|nmod|END_ENTITY	The association of cyclin_A and cyclin kinase inhibitor p21 in response to gamma-irradiation requires the CDK2 binding region , but not the Cy motif .
9548727	0	CDK2	18,22	p21	0,3	CDK2	p21	12566(Tax:10090)	12575(Tax:10090)	Gene	Gene	regulator|compound|START_ENTITY regulator|nsubj|END_ENTITY	p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells .
9811471	0	CDK2	88,92	p21	124,127	CDK2	p21	1017	644914	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Lovastatin mediated G1_arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27 , independent of p53 .
16847309	0	CDK2	62,66	p27Kip1	53,60	CDK2	p27Kip1	12566(Tax:10090)	12576(Tax:10090)	Gene	Gene	ERK1/ERK2|dep|START_ENTITY ERK1/ERK2|compound|END_ENTITY	Docosahexaenoic_acid inhibits cancer cell growth via p27Kip1 , CDK2 , ERK1/ERK2 , and retinoblastoma phosphorylation .
1714386	0	CDK2	32,36	p34	12,15	CDK2	p34	1017	79719	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	A new human p34 protein kinase , CDK2 , identified by complementation of a cdc28 mutation in Saccharomyces_cerevisiae , is a homolog of Xenopus Eg1 .
25860957	0	CDK2	26,30	p53	80,83	CDK2	p53	1017	7157	Gene	Gene	Independently|compound|START_ENTITY Independently|nmod|END_ENTITY	ING5 Is Phosphorylated by CDK2 and Controls Cell Proliferation Independently of p53 .
14985111	0	CDK2-associated_protein-1	19,44	CDK2AP1	56,63	CDK2-associated protein-1	CDK2AP1	8099	8099	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the CDK2-associated_protein-1 , p12 -LRB- DOC-1 / CDK2AP1 -RRB- , with its homolog , p14 -LRB- DOC-1R -RRB- .
14985111	0	CDK2-associated_protein-1	19,44	DOC-1R	88,94	CDK2-associated protein-1	DOC-1R	8099	10263	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the CDK2-associated_protein-1 , p12 -LRB- DOC-1 / CDK2AP1 -RRB- , with its homolog , p14 -LRB- DOC-1R -RRB- .
14985111	0	CDK2AP1	56,63	CDK2-associated_protein-1	19,44	CDK2AP1	CDK2-associated protein-1	8099	8099	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the CDK2-associated_protein-1 , p12 -LRB- DOC-1 / CDK2AP1 -RRB- , with its homolog , p14 -LRB- DOC-1R -RRB- .
14985111	0	CDK2AP1	56,63	DOC-1R	88,94	CDK2AP1	DOC-1R	8099	10263	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the CDK2-associated_protein-1 , p12 -LRB- DOC-1 / CDK2AP1 -RRB- , with its homolog , p14 -LRB- DOC-1R -RRB- .
26515287	0	CDK2AP1	96,103	miR-205	0,7	CDK2AP1	miR-205	13445(Tax:10090)	387201(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression promotes|advcl|suppressing promotes|nsubj|END_ENTITY	miR-205 promotes proliferation and invasion of laryngeal_squamous_cell_carcinoma by suppressing CDK2AP1 expression .
8703009	0	CDK4	45,49	CDC37	34,39	CDK4	CDC37	1019	11140	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical interaction of mammalian CDC37 with CDK4 .
19487459	0	CDK4	54,58	CDK7	115,119	CDK4	CDK7	1019	1022	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|evidence evidence|dep|activated activated|nmod|END_ENTITY	Differential regulation of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and CDK6 , evidence that CDK4 might not be activated by CDK7 , and design of a CDK6 activating mutation .
19487459	0	CDK4	84,88	CDK7	115,119	CDK4	CDK7	1019	1022	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Differential regulation of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and CDK6 , evidence that CDK4 might not be activated by CDK7 , and design of a CDK6 activating mutation .
16027075	0	CDK4	35,39	FHIT	16,20	CDK4	FHIT	1019	2272	Gene	Gene	Expressions|dep|START_ENTITY Expressions|nmod|END_ENTITY	-LSB- Expressions of FHIT and cyclin_D1 / CDK4 in oral_cancer and oral precancerous_lesions -RSB- .
10398121	0	CDK4	83,87	MDM2	93,97	CDK4	MDM2	1019	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
11505267	0	CDK4	6,10	MDM2	0,4	CDK4	MDM2	1019	4193	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	MDM2 + / CDK4 + / p53 + oral_liposarcoma : case report and review of the literature .
18214854	0	CDK4	94,98	MDM2	24,28	CDK4	MDM2	1019	4193	Gene	Gene	belongs|nsubj|START_ENTITY partner|advcl|belongs partner|nmod|END_ENTITY	HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated_liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon .
25803170	0	CDK4	107,111	MDM2	0,4	CDK4	MDM2	1019	4193	Gene	Gene	inhibition|compound|START_ENTITY determine|nmod|inhibition determine|nsubj|turnover turnover|compound|END_ENTITY	MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition .
8221695	0	CDK4	23,27	MDM2	38,42	CDK4	MDM2	1019	4193	Gene	Gene	gene|compound|START_ENTITY Coamplification|nmod|gene Coamplification|nmod|END_ENTITY	Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas .
25779166	0	CDK4	6,10	MEK	0,3	CDK4	MEK	1019	5609	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	MEK + CDK4 a regimen for non-BRAF V6000 melanoma .
9712735	0	CDK4	33,37	P16	69,72	CDK4	P16	1019	1029	Gene	Gene	domains|nmod|START_ENTITY involved|nsubjpass|domains involved|nmod|protein protein|amod|binding binding|nmod|suppressor suppressor|compound|END_ENTITY	Several noncontiguous domains of CDK4 are involved in binding to the P16 tumor suppressor protein .
15699216	0	CDK4	0,4	TNFR1	19,24	CDK4	TNFR1	1019	7132	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control .
10398121	0	CDK4	83,87	TP53	0,4	CDK4	TP53	1019	7157	Gene	Gene	proteins|nummod|START_ENTITY cycle-associated|xcomp|proteins cell|acl|cycle-associated alterations|nmod|cell alterations|nsubj|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
19237565	0	CDK4	27,31	cyclin	57,63	CDK4	cyclin	1019	5111	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human CDK4 in complex with a D-type cyclin .
19017637	0	CDK4	136,140	cyclin-dependent_kinase-4	109,134	CDK4	cyclin-dependent kinase-4	1019	1019	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Artemisinin blocks prostate_cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent_kinase-4 -LRB- CDK4 -RRB- promoter and inhibiting CDK4 gene expression .
19543928	0	CDK4	118,122	cyclin-dependent_kinase_4	91,116	CDK4	cyclin-dependent kinase 4	1019	1019	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Molecular-docking-guided 3D-QSAR studies of substituted isoquinoline-1 ,3 - -LRB- 2H ,4 H -RRB- - diones as cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- inhibitors .
8811128	0	CDK4	48,52	cyclin-dependent_kinase_4	21,46	CDK4	cyclin-dependent kinase 4	1019	1019	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Amplification of the cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- gene is associated with high cdk4 protein levels in glioblastoma multiforme .
10390005	0	CDK4	103,107	cyclin_D1	40,49	CDK4	cyclin D1	1019	595	Gene	Gene	cyclin-dependent_kinase_4|appos|START_ENTITY that|nmod|cyclin-dependent_kinase_4 Comparison|nmod|that Comparison|nmod|END_ENTITY	Comparison of deregulated expression of cyclin_D1 and cyclin E with that of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and CDK2 in human oesophageal_squamous_cell_carcinoma .
10398121	0	CDK4	83,87	cyclin_D1	72,81	CDK4	cyclin D1	1019	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
11016654	0	CDK4	85,89	cyclin_D1	75,84	CDK4	cyclin D1	1019	595	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Loss of p27Kip1 from cyclin E/cyclin-dependent _ kinase _ -LRB- CDK -RRB- _ 2 but not from cyclin_D1 / CDK4 complexes in cells transformed by polyamine biosynthetic enzymes .
11798599	0	CDK4	37,41	cyclin_D1	27,36	CDK4	cyclin D1	1019	595	Gene	Gene	START_ENTITY|dep|-LSB- -LSB-|nmod|END_ENTITY	-LSB- The effect of bombesin on cyclin_D1 / CDK4 of immortalized human gastric epithelial cell line -RSB- .
12657252	0	CDK4	80,84	cyclin_D1	70,79	CDK4	cyclin D1	1019	595	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis of quinolinyl/isoquinolinyl -LSB- a -RSB- pyrrolo _ -LSB- 3,4-c -RSB- _ carbazoles as cyclin_D1 / CDK4 inhibitors .
12824014	0	CDK4	38,42	cyclin_D1	28,37	CDK4	cyclin D1	1019	595	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Novel , potent and selective cyclin_D1 / CDK4 inhibitors : indolo -LSB- 6,7-a -RSB- pyrrolo -LSB- 3,4-c -RSB- carbazoles .
15104433	0	CDK4	80,84	cyclin_D1	70,79	CDK4	cyclin D1	1019	595	Gene	Gene	inhibitors|nsubj|START_ENTITY END_ENTITY|parataxis|inhibitors	Synthetic approaches to indolo -LSB- 6,7-a -RSB- pyrrolo -LSB- 3,4-c -RSB- carbazoles : potent cyclin_D1 / CDK4 inhibitors .
15221443	0	CDK4	35,39	cyclin_D1	25,34	CDK4	cyclin D1	1019	595	Gene	Gene	Pattern|dep|START_ENTITY Pattern|nmod|END_ENTITY	Pattern of expression of cyclin_D1 / CDK4 complex in human placenta during gestation .
16294008	0	CDK4	49,53	cyclin_D1	67,76	CDK4	cyclin D1	481131(Tax:9615)	449028(Tax:9615)	Gene	Gene	START_ENTITY|acl|activated activated|nmod|END_ENTITY	Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin_D1 or cyclin_D3 : differential involvement in the distinct mitogenic modes of thyroid epithelial cells .
16319987	0	CDK4	24,28	cyclin_D1	126,135	CDK4	cyclin D1	1019	595	Gene	Gene	START_ENTITY|dep|Effect Effect|nmod|overexpression overexpression|nmod|inhibition inhibition|amod|END_ENTITY	Validation of cyclin_D1 / CDK4 as an anticancer drug target in MCF-7 breast_cancer cells : Effect of regulated overexpression of cyclin_D1 and siRNA-mediated inhibition of endogenous cyclin_D1 and CDK4 expression .
16319987	0	CDK4	24,28	cyclin_D1	14,23	CDK4	cyclin D1	1019	595	Gene	Gene	Validation|dep|START_ENTITY Validation|nmod|END_ENTITY	Validation of cyclin_D1 / CDK4 as an anticancer drug target in MCF-7 breast_cancer cells : Effect of regulated overexpression of cyclin_D1 and siRNA-mediated inhibition of endogenous cyclin_D1 and CDK4 expression .
16319987	0	CDK4	24,28	cyclin_D1	180,189	CDK4	cyclin D1	1019	595	Gene	Gene	START_ENTITY|dep|Effect Effect|nmod|expression expression|amod|endogenous endogenous|dep|END_ENTITY	Validation of cyclin_D1 / CDK4 as an anticancer drug target in MCF-7 breast_cancer cells : Effect of regulated overexpression of cyclin_D1 and siRNA-mediated inhibition of endogenous cyclin_D1 and CDK4 expression .
16400524	0	CDK4	142,146	cyclin_D1	132,141	CDK4	cyclin D1	510618(Tax:9913)	524530(Tax:9913)	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Recombinant human prothrombin kringle-2 induces bovine capillary endothelial cell cycle arrest at G0-G1 phase through inhibition of cyclin_D1 / CDK4 complex : modulation of reactive oxygen species generation and up-regulation of cyclin-dependent kinase inhibitors .
18353414	0	CDK4	25,29	cyclin_D1	15,24	CDK4	cyclin D1	94201(Tax:10116)	58919(Tax:10116)	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of cyclin_D1 / CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb2 + - induced neuronal_death in cultured hippocampal neurons .
19035289	0	CDK4	116,120	cyclin_D1	106,115	CDK4	cyclin D1	1019	595	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Growth inhibition of human MDA-mB-231 breast_cancer cells by delta-tocotrienol is associated with loss of cyclin_D1 / CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma_tumor suppressor gene product .
20951943	0	CDK4	18,22	cyclin_D1	8,17	CDK4	cyclin D1	1019	595	Gene	Gene	kinase|compound|START_ENTITY regulates|nsubj|kinase END_ENTITY|parataxis|regulates	Nuclear cyclin_D1 / CDK4 kinase regulates CUL4 expression and triggers neoplastic_growth via activation of the PRMT5 methyltransferase .
21077851	0	CDK4	125,129	cyclin_D1	115,124	CDK4	cyclin D1	12567(Tax:10090)	12443(Tax:10090)	Gene	Gene	down-regulation|compound|START_ENTITY down-regulation|nummod|END_ENTITY	The -3 epoxide of eicosapentaenoic_acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin_D1 / CDK4 down-regulation .
26337082	0	CDK4	93,97	cyclin_D1	83,92	CDK4	cyclin D1	1019	595	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Functional , chemical genomic , and super-enhancer screening identify sensitivity to cyclin_D1 / CDK4 pathway inhibition in Ewing_sarcoma .
9228064	0	CDK4	18,22	cyclin_D1	45,54	CDK4	cyclin D1	1019	595	Gene	Gene	sequences|nummod|START_ENTITY Identification|nmod|sequences involved|nsubj|Identification involved|nmod|binding binding|amod|END_ENTITY	Identification of CDK4 sequences involved in cyclin_D1 and p16 binding .
9244353	0	CDK4	22,26	cyclin_D1	77,86	CDK4	cyclin D1	1019	595	Gene	Gene	requirement|nmod|START_ENTITY requirement|dep|evidence evidence|nmod|END_ENTITY	Mutual requirement of CDK4 and Myc in malignant transformation : evidence for cyclin_D1 / CDK4 and p16INK4A as upstream regulators of Myc .
9244353	0	CDK4	87,91	cyclin_D1	77,86	CDK4	cyclin D1	1019	595	Gene	Gene	requirement|dep|START_ENTITY requirement|dep|evidence evidence|nmod|END_ENTITY	Mutual requirement of CDK4 and Myc in malignant transformation : evidence for cyclin_D1 / CDK4 and p16INK4A as upstream regulators of Myc .
9372967	0	CDK4	91,95	cyclin_D1	20,29	CDK4	cyclin D1	1019	595	Gene	Gene	cyclin-dependent_kinase_4|appos|START_ENTITY import|nmod|cyclin-dependent_kinase_4 prevents|dobj|import prevents|nsubj|mutant mutant|amod|END_ENTITY	A dominant-negative cyclin_D1 mutant prevents nuclear import of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and its phosphorylation by CDK-activating kinase .
10022885	0	CDK4	47,51	p16	22,25	CDK4	p16	1019	1029	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|expression expression|nmod|END_ENTITY	Induced expression of p16 -LRB- INK4a -RRB- inhibits both CDK4 - and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes .
10488417	0	CDK4	24,28	p16	19,22	CDK4	p16	1019	1029	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression of p16 , CDK4 and pRb in hepatocellular_carcinomas -RSB- .
10681785	0	CDK4	25,29	p16	20,23	CDK4	p16	1019	1029	Gene	Gene	proteins|compound|START_ENTITY -RSB-|nsubj|proteins -RSB-|advcl|-LSB- -LSB-|dobj|expressions expressions|nmod|END_ENTITY	-LSB- The expressions of p16 , CDK4 and PCNA proteins in trophoblastic_tumors -RSB- .
12212108	0	CDK4	44,48	p16	26,29	CDK4	p16	1019	1029	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- The effects of exogenous p16 expression on CDK4 , Cyclin_D1 and pRb in nasopharyngeal_carcinoma cell lines -RSB- .
25109634	0	CDK4	59,63	p16	54,57	CDK4	p16	1019	1029	Gene	Gene	2|nummod|START_ENTITY 2|nummod|END_ENTITY	Alterations of cell cycle control proteins SHP __ -1 / 2 , p16 , CDK4 and cyclin_D1 in radioresistant nasopharyngeal_carcinoma cells .
7954404	0	CDK4	0,4	p16	50,53	CDK4	p16	1019	1029	Gene	Gene	amplification|compound|START_ENTITY mechanism|nsubj|amplification mechanism|nmod|deletion deletion|amod|END_ENTITY	CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines .
8621248	0	CDK4	40,44	p16	35,38	CDK4	p16	1019	1029	Gene	Gene	p15|nummod|START_ENTITY p15|nummod|END_ENTITY	Infrequent alterations of the p15 , p16 , CDK4 and cyclin_D1 genes in non-astrocytic human brain_tumors .
10465111	0	CDK4	49,53	p16INK4a	39,47	CDK4	p16INK4a	1019	1029	Gene	Gene	N-ras|nummod|START_ENTITY N-ras|nummod|END_ENTITY	Mutational analysis of the N-ras , p53 , p16INK4a , CDK4 , and MC1R genes in human congenital_melanocytic_naevi .
8898364	0	CDK4	59,63	p18INK4c	13,21	CDK4	p18INK4c	12567(Tax:10090)	12580(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation .
10398121	0	CDK4	83,87	p21	67,70	CDK4	p21	1019	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
23737759	0	CDK4	0,4	p21	103,106	CDK4	p21	1019	644914	Gene	Gene	phosphorylation|compound|START_ENTITY central|nsubj|phosphorylation central|nmod|CDK4/CDK2 CDK4/CDK2|acl|mediated mediated|nmod|phosphorylation phosphorylation|amod|END_ENTITY	CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point .
9349504	0	CDK4	31,35	p21	15,18	CDK4	p21	1019	1026	Gene	Gene	WAF1/Cip1|appos|START_ENTITY WAF1/Cip1|amod|END_ENTITY	Involvement of p21 -LRB- WAF1/Cip1 -RRB- , CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition .
10490638	0	CDK4	23,27	p27	66,69	CDK4	p27	12567(Tax:10090)	12576(Tax:10090)	Gene	Gene	entry|nummod|START_ENTITY disruption|nmod|entry disruption|nmod|activity activity|amod|END_ENTITY	Targeted disruption of CDK4 delays cell cycle entry with enhanced p27 -LRB- Kip1 -RRB- activity .
12781329	0	CDK4	116,120	p27	181,184	CDK4	p27	1019	3429	Gene	Gene	down-regulation|nmod|START_ENTITY pentagalloylglucose|nmod|down-regulation activities|amod|pentagalloylglucose Induction|nmod|activities Induction|nmod|END_ENTITY	Induction of G1 phase arrest in MCF human breast_cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27 -LRB- Kip -RRB- and p21 -LRB- Cip -RRB- .
10465111	0	CDK4	49,53	p53	34,37	CDK4	p53	1019	7157	Gene	Gene	N-ras|nummod|START_ENTITY N-ras|nummod|END_ENTITY	Mutational analysis of the N-ras , p53 , p16INK4a , CDK4 , and MC1R genes in human congenital_melanocytic_naevi .
7923152	0	CDK4I	90,95	cyclin-dependent_kinase_4	48,73	CDK4I	cyclin-dependent kinase 4	1019	1019	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rarity of somatic and germline mutations of the cyclin-dependent_kinase_4 inhibitor gene , CDK4I , in melanoma .
25452387	0	CDK5	0,4	DLC1	50,54	CDK5	DLC1	1020	10395	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	CDK5 is a major regulator of the tumor suppressor DLC1 .
9822744	0	CDK5	54,58	P35	69,72	CDK5	P35	1020	8851	Gene	Gene	activator|compound|START_ENTITY participation|nmod|activator Evidence|nmod|participation END_ENTITY|nsubj|Evidence	Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth .
26860827	0	CDK5	59,63	cyclin-dependent_kinase_5	32,57	CDK5	cyclin-dependent kinase 5	1020	1020	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	An immunohistochemical study of cyclin-dependent_kinase_5 -LRB- CDK5 -RRB- expression in non-small cell lung_cancer -LRB- NSCLC -RRB- and small cell lung_cancer -LRB- SCLC -RRB- : a possible prognostic biomarker .
25827073	0	CDK5	83,87	miR-21	76,82	CDK5	miR-21	1020	406991	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21 / CDK5 axis .
17121855	0	CDK5	49,53	p25	71,74	CDK5	p25	140908(Tax:10116)	170496(Tax:10116)	Gene	Gene	activator|compound|START_ENTITY cleavage|nmod|activator Suppression|nmod|cleavage p35|nsubj|Suppression p35|nmod|END_ENTITY	Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation .
17121855	0	CDK5	49,53	p35	64,67	CDK5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	activator|compound|START_ENTITY cleavage|nmod|activator Suppression|nmod|cleavage END_ENTITY|nsubj|Suppression	Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation .
18325333	0	CDK5	71,75	p35	15,18	CDK5	p35	1020	8851	Gene	Gene	precursor|nmod|START_ENTITY downregulates|dobj|precursor downregulates|nsubj|END_ENTITY	CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5 .
19544209	0	CDK5	50,54	p35	66,69	CDK5	p35	733700(Tax:9823)	396942(Tax:9823)	Gene	Gene	porcine|dep|START_ENTITY genes|amod|porcine genes|appos|END_ENTITY	Cloning and spatio-temporal expression of porcine CDK5 and CDK5R1 -LRB- p35 -RRB- genes .
20181942	0	CDK5	20,24	p35	0,3	CDK5	p35	1020	8851	Gene	Gene	activation|nummod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	p35 is required for CDK5 activation in cellular senescence .
25864429	0	CDK5	79,83	p35	0,3	CDK5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	silencing|compound|START_ENTITY induced|nmod|silencing improvement|acl|induced underlie|dobj|improvement underlie|nsubj|END_ENTITY	p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing .
26444778	0	CDK5	70,74	p35	86,89	CDK5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	Activator|compound|START_ENTITY Activator|appos|END_ENTITY	Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator , p35 , CDKR1 Protein .
9837783	0	CDK5	60,64	p35	39,42	CDK5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	activator|nmod|START_ENTITY degradation|appos|activator degradation|nmod|END_ENTITY	Okadaic_acid-stimulated degradation of p35 , an activator of CDK5 , by proteasome in cultured neurons .
22860085	0	CDK5RAP3	0,8	p14ARF	33,39	CDK5RAP3	p14ARF	80279	1029	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	CDK5RAP3 is a novel repressor of p14ARF in hepatocellular_carcinoma cells .
26692922	0	CDK6	76,80	H19	0,3	CDK6	H19	1021	283120	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	H19 derived microRNA-675 regulates cell proliferation and migration through CDK6 in glioma .
24736461	0	CDK6	32,36	MLL	0,3	CDK6	MLL	1021	4297	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL .
26396669	0	CDK6	58,62	MiRNA-29c	0,9	CDK6	MiRNA-29c	1021	407026	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiRNA-29c regulates cell growth and invasion by targeting CDK6 in bladder_cancer .
26822763	0	CDK6	92,96	NEAT1	19,24	CDK6	NEAT1	1021	283131	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Long noncoding RNA NEAT1 promotes laryngeal_squamous_cell_cancer through regulating miR-107 / CDK6 pathway .
11739795	0	CDK6	30,34	cyclin	46,52	CDK6	cyclin	1021	5111	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	CAK-independent activation of CDK6 by a viral cyclin .
11828325	0	CDK6	21,25	cyclin	56,62	CDK6	cyclin	1021	5111	Gene	Gene	basis|nmod|START_ENTITY activation|nsubj|basis activation|nmod|END_ENTITY	Structural basis for CDK6 activation by a virus-encoded cyclin .
18183592	0	CDK6	107,111	cyclin_D3	97,106	CDK6	cyclin D3	1021	896	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Pure antiestrogen-induced G1-arrest in myeloma cells results from the reduced kinase activity of cyclin_D3 / CDK6 complexes whereas apoptosis is mediated by endoplasmic reticulum-dependent caspases .
15504546	0	CDK6	75,79	tumor_necrosis_factor-alpha	24,51	CDK6	tumor necrosis factor-alpha	1021	7124	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	In human immature BFU-E tumor_necrosis_factor-alpha not only downregulates CDK6 but also directly produces apoptosis which is prevented by stem_cell_factor .
19487459	0	CDK7	115,119	CDK4	54,58	CDK7	CDK4	1022	1019	Gene	Gene	activated|nmod|START_ENTITY evidence|dep|activated regulation|appos|evidence regulation|nmod|END_ENTITY	Differential regulation of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and CDK6 , evidence that CDK4 might not be activated by CDK7 , and design of a CDK6 activating mutation .
19487459	0	CDK7	115,119	CDK4	84,88	CDK7	CDK4	1022	1019	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Differential regulation of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and CDK6 , evidence that CDK4 might not be activated by CDK7 , and design of a CDK6 activating mutation .
8700522	0	CDK8	9,13	Cyclin_C	0,8	CDK8	Cyclin C	1024	892	Gene	Gene	kinase|nsubj|START_ENTITY END_ENTITY|parataxis|kinase	Cyclin_C / CDK8 is a novel CTD kinase associated with RNA polymerase II .
25305448	0	CDK8	24,28	K-ras	8,13	CDK8	K-ras	264064(Tax:10090)	16653(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic_cancer in part via the Wnt/b-catenin signaling pathway .
25281924	0	CDK9	99,103	MicroRNA-874	0,12	CDK9	MicroRNA-874	1025	100126343	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast_cancer by targeting CDK9 .
16552184	0	CDK9	0,4	p53	20,23	CDK9	p53	1025	7157	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|iobj|END_ENTITY	CDK9 phosphorylates p53 on serine residues 33 , 315 and 392 .
26745862	0	CDK9	128,132	p53	82,85	CDK9	p53	1025	7157	Gene	Gene	Inhibition|compound|START_ENTITY Function|nmod|Inhibition Allows|xcomp|Function Allows|dobj|END_ENTITY	The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition .
27049325	0	CDKAL1	36,42	ADRA2A	28,34	CDKAL1	ADRA2A	54901	150	Gene	Gene	GRB10|appos|START_ENTITY GRB10|appos|END_ENTITY	Risk Alleles in/near ADCY5 , ADRA2A , CDKAL1 , CDKN2A/B , GRB10 , and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood : Results from the FAMILY Study .
18469204	0	CDKAL1	60,66	CDKN2A/B	68,76	CDKAL1	CDKN2A/B	54901	1029;1030	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
18633108	0	CDKAL1	19,25	CDKN2A/B	27,35	CDKAL1	CDKN2A/B	54901	1029;1030	Gene	Gene	SLC30A8|compound|START_ENTITY SLC30A8|appos|END_ENTITY	Common variants in CDKAL1 , CDKN2A/B , IGF2BP2 , SLC30A8 , and HHEX/IDE genes are associated with type 2 diabetes and impaired_fasting_glucose in a Chinese Han population .
20509872	0	CDKAL1	52,58	CDKN2A/B	60,68	CDKAL1	CDKN2A/B	54901	1029;1030	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
27049325	0	CDKAL1	36,42	CDKN2A/B	44,52	CDKAL1	CDKN2A/B	54901	1029;1030	Gene	Gene	GRB10|appos|START_ENTITY GRB10|appos|END_ENTITY	Risk Alleles in/near ADCY5 , ADRA2A , CDKAL1 , CDKN2A/B , GRB10 , and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood : Results from the FAMILY Study .
19008344	0	CDKAL1	47,53	EXT2	70,74	CDKAL1	EXT2	54901	2132	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	CDKAL1	47,53	FTO	42,45	CDKAL1	FTO	54901	79068	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|compound|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	CDKAL1	52,58	FTO	79,82	CDKAL1	FTO	54901	79068	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	CDKAL1	60,66	HHEX	54,58	CDKAL1	HHEX	54901	3087	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
19008344	0	CDKAL1	47,53	HHEX	64,68	CDKAL1	HHEX	54901	3087	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	CDKAL1	52,58	HHEX	46,50	CDKAL1	HHEX	54901	3087	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
22487833	0	CDKAL1	58,64	HHEX	75,79	CDKAL1	HHEX	54901	3087	Gene	Gene	genes|nummod|START_ENTITY genes|dep|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
18597214	0	CDKAL1	32,38	IGF2BP2	23,30	CDKAL1	IGF2BP2	54901	10644	Gene	Gene	HHEX|nummod|START_ENTITY HHEX|nummod|END_ENTITY	Variants of the PPARG , IGF2BP2 , CDKAL1 , HHEX , and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies .
18633108	0	CDKAL1	19,25	IGF2BP2	37,44	CDKAL1	IGF2BP2	54901	10644	Gene	Gene	SLC30A8|compound|START_ENTITY SLC30A8|appos|END_ENTITY	Common variants in CDKAL1 , CDKN2A/B , IGF2BP2 , SLC30A8 , and HHEX/IDE genes are associated with type 2 diabetes and impaired_fasting_glucose in a Chinese Han population .
19008344	0	CDKAL1	47,53	IGF2BP2	76,83	CDKAL1	IGF2BP2	54901	10644	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	CDKAL1	52,58	IGF2BP2	70,77	CDKAL1	IGF2BP2	54901	10644	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19862325	0	CDKAL1	15,21	KCNJ11	7,13	CDKAL1	KCNJ11	54901	3767	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	PPARG , KCNJ11 , CDKAL1 , CDKN2A-CDKN2B , IDE-KIF11-HHEX , IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population .
22443257	0	CDKAL1	78,84	KCNJ11	92,98	CDKAL1	KCNJ11	54901	3767	Gene	Gene	TCF7L2|nummod|START_ENTITY TCF7L2|nummod|END_ENTITY	Polycystic_ovary_syndrome is not associated with polymorphisms of the TCF7L2 , CDKAL1 , HHEX , KCNJ11 , FTO and SLC30A8 genes .
19862325	0	CDKAL1	15,21	PPARG	0,5	CDKAL1	PPARG	54901	5468	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	PPARG , KCNJ11 , CDKAL1 , CDKN2A-CDKN2B , IDE-KIF11-HHEX , IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population .
18162508	0	CDKAL1	15,21	SLC30A8	48,55	CDKAL1	SLC30A8	54901	169026	Gene	Gene	HHEX|nummod|START_ENTITY HHEX|nummod|END_ENTITY	Association of CDKAL1 , IGF2BP2 , CDKN2A/B , HHEX , SLC30A8 , and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population .
18469204	0	CDKAL1	60,66	SLC30A8	45,52	CDKAL1	SLC30A8	54901	169026	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
19008344	0	CDKAL1	47,53	SLC30A8	55,62	CDKAL1	SLC30A8	54901	169026	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	CDKAL1	52,58	SLC30A8	37,44	CDKAL1	SLC30A8	54901	169026	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|compound|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
22487833	0	CDKAL1	58,64	SLC30A8	66,73	CDKAL1	SLC30A8	54901	169026	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
20509872	0	CDKAL1	52,58	TCF2	84,88	CDKAL1	TCF2	54901	6928	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	CDKAL1	60,66	TCF7L2	37,43	CDKAL1	TCF7L2	54901	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
22487833	0	CDKAL1	58,64	TCF7L2	50,56	CDKAL1	TCF7L2	54901	6934	Gene	Gene	genes|nummod|START_ENTITY genes|compound|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
20847106	0	CDKAL1	91,97	cyclin-dependent_kinase_5_regulatory_subunit-associated_protein_1-like_1	17,89	CDKAL1	cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1	54901	54901	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of a cyclin-dependent_kinase_5_regulatory_subunit-associated_protein_1-like_1 -LRB- CDKAL1 -RRB- polymorphism with elevated hemoglobin A -LRB- c -RRB- levels and the prevalence of metabolic_syndrome in Japanese men : interaction with dietary energy intake .
20211261	0	CDKL5	0,5	MeCP2	17,22	CDKL5	MeCP2	100362725	29386(Tax:10116)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	CDKL5 is a brain MeCP2 target gene regulated by DNA methylation .
23242510	0	CDKL5	51,56	cyclin-dependent_kinase-like_5	19,49	CDKL5	cyclin-dependent kinase-like 5	6792	6792	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations in cyclin-dependent_kinase-like_5 -LRB- CDKL5 -RRB- gene in Indian cases of Rett_syndrome .
26701947	0	CDKL5	118,123	cyclin-dependent_kinase-like_5	86,116	CDKL5	cyclin-dependent kinase-like 5	6792	6792	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Turkish cases of early infantile epileptic_encephalopathy : two novel mutations in the cyclin-dependent_kinase-like_5 -LRB- CDKL5 -RRB- gene .
23329847	0	CDKN1A	61,67	BOZF1	86,91	CDKN1A	BOZF1	1026	653121	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Regulation of the cyclin-dependent kinase inhibitor 1A gene -LRB- CDKN1A -RRB- by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding .
23715670	0	CDKN1A	74,80	CDKN2B	82,88	CDKN1A	CDKN2B	1026	1030	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A , CDKN2B , and CDKN2C in sporadic parathyroid_adenomas .
26067234	0	CDKN1A	15,21	MAF1	0,4	CDKN1A	MAF1	1026	84232	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	MAF1 represses CDKN1A through a Pol III-dependent mechanism .
25695884	0	CDKN1A	77,83	MicroRNA-93	0,11	CDKN1A	MicroRNA-93	1026	407051	Gene	Gene	Proliferation|dep|START_ENTITY Proliferation|compound|END_ENTITY	MicroRNA-93 Promotes Ovarian Granulosa Cells Proliferation Through Targeting CDKN1A in Polycystic_Ovarian_Syndrome .
19118657	0	CDKN1A	42,48	Oct-1	15,20	CDKN1A	Oct-1	1026	6580	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Oct-1 in the regulation of CDKN1A in response to clinically relevant doses of ionizing radiation .
18263614	0	CDKN1A	19,25	PCNA	32,36	CDKN1A	PCNA	1026	5111	Gene	Gene	p21|appos|START_ENTITY p21|nmod|END_ENTITY	Interaction of p21 -LRB- CDKN1A -RRB- with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair .
26846300	0	CDKN1A	16,22	SOX2	0,4	CDKN1A	SOX2	1026	6657	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	SOX2 suppresses CDKN1A to sustain growth of lung_squamous_cell_carcinoma .
19122196	0	CDKN1A	102,108	p21	97,100	CDKN1A	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 -LRB- CDKN1A -RRB- gene in response to 1alpha,25-dihydroxyvitamin _ D3 .
20126416	0	CDKN1A	62,68	p21	57,60	CDKN1A	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the p21 -LRB- CDKN1A -RRB- gene and correlations with longevity in the Italian population .
20549306	0	CDKN1A	30,36	p21	26,29	CDKN1A	p21	1026	1026	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Beryllium_sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types .
22996374	0	CDKN1A	68,74	p21	75,78	CDKN1A	p21	1026	1026	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Detection and significance of human_papillomavirus , CDKN2A -LRB- p16 -RRB- and CDKN1A -LRB- p21 -RRB- expression in squamous_cell_carcinoma of the larynx .
23322738	0	CDKN1A	78,84	p21	73,76	CDKN1A	p21	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tenovin-D3 , a novel small-molecule inhibitor of sirtuin SirT2 , increases p21 -LRB- CDKN1A -RRB- expression in a p53-independent manner .
26231713	0	CDKN1A	67,73	p21	63,66	CDKN1A	p21	1026	1026	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Assessing Cell Cycle Independent Function of the CDK Inhibitor p21 -LRB- CDKN1A -RRB- in DNA Repair .
26231713	0	CDKN1A	67,73	p21	63,66	CDKN1A	p21	1026	1026	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Assessing Cell Cycle Independent Function of the CDK Inhibitor p21 -LRB- CDKN1A -RRB- in DNA Repair .
23342268	0	CDKN1B	108,114	Id3	79,82	CDKN1B	Id3	1027	3399	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Id1 and Id3 expression is associated with increasing grade of prostate_cancer : Id3 preferentially regulates CDKN1B .
16169901	0	CDKN1B	74,80	p27kip1	82,89	CDKN1B	p27kip1	1027	1027	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The MLL fusion gene , MLL-AF4 , regulates cyclin-dependent kinase inhibitor CDKN1B -LRB- p27kip1 -RRB- expression .
19340297	0	CDKN1C	0,6	EZH2	35,39	CDKN1C	EZH2	1028	2146	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	CDKN1C -LRB- p57 -RRB- is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast_cancer cells .
25960208	0	CDKN1C	55,61	miR-25	0,6	CDKN1C	miR-25	1028	407014	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-25 promotes glioma cell proliferation by targeting CDKN1C .
10378889	0	CDKN2	19,24	p16	14,17	CDKN2	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Alteration of p16 -LRB- CDKN2 -RRB- gene is associated with interleukin-2-induced tumor cell growth in adult_T-cell_leukemia .
17466040	0	CDKN2	4,9	p16	0,3	CDKN2	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p16 -LRB- CDKN2 -RRB- gene polymorphism : association with histologic subtypes of epithelial_ovarian_cancer in China .
7668266	0	CDKN2	125,130	p16	120,123	CDKN2	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosome 9p deletions in cutaneous_malignant_melanoma_tumors : the minimal deleted region involves markers outside the p16 -LRB- CDKN2 -RRB- gene .
7987388	0	CDKN2	26,31	p16	16,19	CDKN2	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the p16 gene -LRB- CDKN2 -RRB- as a candidate for the chromosome 9p melanoma susceptibility locus .
8570179	0	CDKN2	26,31	p16	16,19	CDKN2	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the p16 gene , CDKN2 , in 17 Australian melanoma kindreds .
8589032	0	CDKN2	15,20	p16	22,25	CDKN2	p16	1029	1029	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of CDKN2 -LRB- p16 -RRB- in non-small_cell_lung_cancer .
9309120	0	CDKN2	78,83	p16	74,77	CDKN2	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequent allelic losses of 9p21 markers and low incidence of mutations at p16 -LRB- CDKN2 -RRB- gene in non-Hodgkin_lymphomas of B-cell lineage .
9815578	0	CDKN2	23,28	p16	30,33	CDKN2	p16	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Frequent alteration of CDKN2 -LRB- p16 -LRB- INK4A -RRB- / MTS1 -RRB- expression in human primary_prostate_carcinomas .
8791272	0	CDKN2	28,33	p16INK4	19,26	CDKN2	p16INK4	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Involvement of the p16INK4 -LRB- CDKN2 -RRB- gene in familial_melanoma .
20424228	0	CDKN2A	67,73	HHEX	61,65	CDKN2A	HHEX	1029	3087	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
25511139	0	CDKN2A	75,81	IGH	83,86	CDKN2A	IGH	1029	3492	Gene	Gene	Alterations|appos|START_ENTITY Alterations|appos|END_ENTITY	Cytogenetic and Flow Cytometry Evaluation of Richter_Syndrome Reveals MYC , CDKN2A , IGH Alterations With Loss of CD52 , CD62L and Increase of CD71 Antigen Expression as the Most Frequent Recurrent Abnormalities .
20424228	0	CDKN2A	67,73	KCNJ11	36,42	CDKN2A	KCNJ11	1029	3767	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
22288845	0	CDKN2A	64,70	MGMT	58,62	CDKN2A	MGMT	1029	4255	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|compound|END_ENTITY	Identification of promoter region methylation patterns of MGMT , CDKN2A , GSTP1 , and THBS1 genes in intracranial_meningioma patients .
9439668	0	CDKN2A	156,162	P16INK4A	164,172	CDKN2A	P16INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inherited susceptibility to several cancers but absence of linkage between dysplastic_nevus_syndrome and CDKN2A in a melanoma family with a mutation in the CDKN2A -LRB- P16INK4A -RRB- gene .
20424228	0	CDKN2A	67,73	PPARG	29,34	CDKN2A	PPARG	1029	5468	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	CDKN2A	67,73	SLC30A8	52,59	CDKN2A	SLC30A8	1029	169026	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	CDKN2A	67,73	TCF7L2	44,50	CDKN2A	TCF7L2	1029	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
9546285	0	CDKN2A	25,31	TP53	53,57	CDKN2A	TP53	1029	7157	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL .
10373639	0	CDKN2A	27,33	Tumor_suppressor	0,16	CDKN2A	Tumor suppressor	1029	7248	Gene	Gene	p16|appos|START_ENTITY p16|amod|END_ENTITY	Tumor_suppressor gene p16 -LRB- CDKN2A -RRB- mutation status and promoter inactivation in head_and_neck_cancer .
9466670	0	CDKN2A	54,60	cyclin-dependent-kinase-4	17,42	CDKN2A	cyclin-dependent-kinase-4	1029	1019	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The gene for the cyclin-dependent-kinase-4 inhibitor , CDKN2A , is preferentially deleted in malignant_mesothelioma .
14991744	0	CDKN2A	58,64	cyclin-dependent_kinase_inhibitor_2A	20,56	CDKN2A	cyclin-dependent kinase inhibitor 2A	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inactivation of the cyclin-dependent_kinase_inhibitor_2A -LRB- CDKN2A -RRB- gene in squamous_cell_carcinoma of the larynx .
17970080	0	CDKN2A	66,72	p14ARF	74,80	CDKN2A	p14ARF	1029	1029	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Promoter hypermethylation and quantitative expression analysis of CDKN2A -LRB- p14ARF and p16INK4a -RRB- gene in esophageal_squamous_cell_carcinoma .
18804414	0	CDKN2A	4,10	p16	0,3	CDKN2A	p16	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p16 -LRB- CDKN2A -RRB- expression during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide .
20569442	0	CDKN2A	24,30	p16	43,46	CDKN2A	p16	1029	1029	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular_carcinoma .
22751687	0	CDKN2A	20,26	p16	16,19	CDKN2A	p16	101089220	1029	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The presence of p16 CDKN2A protein immunostaining within feline nasal_planum_squamous_cell_carcinomas is associated with an increased survival time and the presence of papillomaviral DNA .
24944814	0	CDKN2A	24,30	p16	20,23	CDKN2A	p16	1029	1029	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between p16 -LRB- CDKN2A -RRB- C540G polymorphism and tumor behavior in prolactinoma : A single-center study .
25921285	0	CDKN2A	0,6	p16	8,11	CDKN2A	p16	1029	1029	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	CDKN2A -LRB- p16 -RRB- mRNA decreased expression is a marker of poor prognosis in malignant high-grade glioma .
9041193	0	CDKN2A	38,44	p16	33,36	CDKN2A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion map of chromosome 9 and p16 -LRB- CDKN2A -RRB- gene alterations in neuroblastoma .
9872329	0	CDKN2A	9,15	p16	4,7	CDKN2A	p16	1029	1029	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The p16 -LRB- CDKN2A -RRB- gene is involved in the growth of neuroblastoma cells and its expression is associated with prognosis of neuroblastoma patients .
9462707	0	CDKN2A	17,23	p16INK4a	25,33	CDKN2A	p16INK4a	1029	1029	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the CDKN2A -LRB- p16INK4a -RRB- gene in microdissected sporadic primary melanomas .
27049325	0	CDKN2A/B	44,52	ADRA2A	28,34	CDKN2A/B	ADRA2A	1029;1030	150	Gene	Gene	GRB10|appos|START_ENTITY GRB10|appos|END_ENTITY	Risk Alleles in/near ADCY5 , ADRA2A , CDKAL1 , CDKN2A/B , GRB10 , and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood : Results from the FAMILY Study .
18469204	0	CDKN2A/B	68,76	CDKAL1	60,66	CDKN2A/B	CDKAL1	1029;1030	54901	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
18633108	0	CDKN2A/B	27,35	CDKAL1	19,25	CDKN2A/B	CDKAL1	1029;1030	54901	Gene	Gene	SLC30A8|appos|START_ENTITY SLC30A8|compound|END_ENTITY	Common variants in CDKAL1 , CDKN2A/B , IGF2BP2 , SLC30A8 , and HHEX/IDE genes are associated with type 2 diabetes and impaired_fasting_glucose in a Chinese Han population .
20509872	0	CDKN2A/B	60,68	CDKAL1	52,58	CDKN2A/B	CDKAL1	1029;1030	54901	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
27049325	0	CDKN2A/B	44,52	CDKAL1	36,42	CDKN2A/B	CDKAL1	1029;1030	54901	Gene	Gene	GRB10|appos|START_ENTITY GRB10|appos|END_ENTITY	Risk Alleles in/near ADCY5 , ADRA2A , CDKAL1 , CDKN2A/B , GRB10 , and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood : Results from the FAMILY Study .
20509872	0	CDKN2A/B	60,68	FTO	79,82	CDKN2A/B	FTO	1029;1030	79068	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	CDKN2A/B	68,76	HHEX	54,58	CDKN2A/B	HHEX	1029;1030	3087	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20509872	0	CDKN2A/B	60,68	HHEX	46,50	CDKN2A/B	HHEX	1029;1030	3087	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18633108	0	CDKN2A/B	27,35	IGF2BP2	37,44	CDKN2A/B	IGF2BP2	1029;1030	10644	Gene	Gene	SLC30A8|appos|START_ENTITY SLC30A8|appos|END_ENTITY	Common variants in CDKAL1 , CDKN2A/B , IGF2BP2 , SLC30A8 , and HHEX/IDE genes are associated with type 2 diabetes and impaired_fasting_glucose in a Chinese Han population .
20509872	0	CDKN2A/B	60,68	IGF2BP2	70,77	CDKN2A/B	IGF2BP2	1029;1030	10644	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	CDKN2A/B	68,76	SLC30A8	45,52	CDKN2A/B	SLC30A8	1029;1030	169026	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20509872	0	CDKN2A/B	60,68	SLC30A8	37,44	CDKN2A/B	SLC30A8	1029;1030	169026	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|compound|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	CDKN2A/B	60,68	TCF2	84,88	CDKN2A/B	TCF2	1029;1030	6928	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	CDKN2A/B	68,76	TCF7L2	37,43	CDKN2A/B	TCF7L2	1029;1030	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
23715670	0	CDKN2B	82,88	CDKN1A	74,80	CDKN2B	CDKN1A	1030	1026	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A , CDKN2B , and CDKN2C in sporadic parathyroid_adenomas .
25663546	0	CDKN2B	60,66	DC-SCRIPT	0,9	CDKN2B	DC-SCRIPT	1030	167465	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERa-positive breast_cancer cells .
26596284	0	CDKN2B	0,6	TGFb	17,21	CDKN2B	TGFb	1030	7040	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	CDKN2B Regulates TGFb Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels .
10541865	0	CDKN2B	65,71	p15	73,76	CDKN2B	p15	1030	1030	Gene	Gene	CDKN2A|dep|START_ENTITY CDKN2A|appos|END_ENTITY	Functional evidence for a role of combined CDKN2A -LRB- p16-p14 -LRB- ARF -RRB- -RRB- / CDKN2B -LRB- p15 -RRB- gene inactivation in malignant_gliomas .
19014416	0	CDKN2B	129,135	p15	137,140	CDKN2B	p15	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting : application to the CDKN2B -LRB- p15 -RRB- gene .
18973139	0	CDKN2C	21,27	p18INK4c	29,37	CDKN2C	p18INK4c	12580(Tax:10090)	12580(Tax:10090)	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Frequent loss of the CDKN2C -LRB- p18INK4c -RRB- gene product in pituitary_adenomas .
26019450	0	CDKN2D	85,91	MiR-451	0,7	CDKN2D	MiR-451	1032	574411	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-451 inhibits proliferation of esophageal_carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1 .
26019450	0	CDKN2D	85,91	MiR-451	0,7	CDKN2D	MiR-451	1032	574411	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-451 inhibits proliferation of esophageal_carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1 .
21912429	0	CDKN2a	64,70	p16_INK4a	23,32	CDKN2a	p16 INK4a	1029	1029	Gene	Gene	methylation|nmod|START_ENTITY methylation|amod|END_ENTITY	Inverse association of p16_INK4a and p14_ARF methylation of the CDKN2a locus in different Gleason_scores_of_prostate_cancer .
12191913	0	CDM	4,7	DOCK2	16,21	CDM	DOCK2	800	1794	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nsubj|protein	The CDM protein DOCK2 in lymphocyte migration .
12121354	0	CDMP1	59,64	cartilage-derived_morphogenetic_protein-1	16,57	CDMP1	cartilage-derived morphogenetic protein-1	8200	8200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation in the cartilage-derived_morphogenetic_protein-1 -LRB- CDMP1 -RRB- gene in a kindred affected with fibular_hypoplasia and complex brachydactyly -LRB- DuPan_syndrome -RRB- .
19038017	0	CDMP1	77,82	cartilage-derived_morphogenetic_protein-1	34,75	CDMP1	cartilage-derived morphogenetic protein-1	8200	8200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel insertion mutation in the cartilage-derived_morphogenetic_protein-1 -LRB- CDMP1 -RRB- gene underlies Grebe-type_chondrodysplasia in a consanguineous Pakistani family .
12124730	0	CDMP1	70,75	cartilage-derived_morphogenetic_protein_1	27,68	CDMP1	cartilage-derived morphogenetic protein 1	8200	8200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frameshift mutation in the cartilage-derived_morphogenetic_protein_1 -LRB- CDMP1 -RRB- gene and severe acromesomelic_chondrodysplasia resembling Grebe-type_chondrodysplasia .
19777340	0	CDNF	98,102	BDNF	49,53	CDNF	BDNF	227526(Tax:10090)	12064(Tax:10090)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and cerebral_dopamine_neurotrophic_factor -LRB- CDNF -RRB- by anti-parkinsonian drug therapy in vivo .
24633814	0	CDNF	11,15	Bax	82,85	CDNF	Bax	361276(Tax:10116)	24887(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2 / Bax and caspase-3 activation .
26785325	0	CDO1	84,88	cysteine_dioxygenase_1	60,82	CDO1	cysteine dioxygenase 1	1036	1036	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Prognostic Significance of Promoter DNA Hypermethylation of cysteine_dioxygenase_1 -LRB- CDO1 -RRB- Gene in Primary Breast_Cancer .
11584018	0	CDP	51,54	CCAAT_displacement_protein	23,49	CDP	CCAAT displacement protein	1523	1523	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Phosphorylation of the CCAAT_displacement_protein -LRB- CDP -RRB- / Cux transcription factor by cyclin_A-Cdk1 modulates its DNA binding activity in G -LRB- 2 -RRB- .
11371564	0	CDP	12,15	CXCL1	46,51	CDP	CXCL1	1523	2919	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	The role of CDP in the negative regulation of CXCL1 gene expression .
11584018	0	CDP	51,54	Cux	56,59	CDP	Cux	1523	1523	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Phosphorylation of the CCAAT_displacement_protein -LRB- CDP -RRB- / Cux transcription factor by cyclin_A-Cdk1 modulates its DNA binding activity in G -LRB- 2 -RRB- .
9806839	0	CDP-diacylglycerol_synthase	52,79	CDS	81,84	CDP-diacylglycerol synthase	CDS	132001	132001	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Isolation and chromosomal localization of two human CDP-diacylglycerol_synthase -LRB- CDS -RRB- genes .
8497074	0	CDR-3	29,34	CD4	45,48	CDR-3	CD4	8163	920	Gene	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	A monoclonal antibody to the CDR-3 region of CD4 inhibits soluble CD4 binding to virions of human_immunodeficiency_virus_type_1 .
26683098	0	CDR1	36,40	VSNL1	43,48	CDR1	VSNL1	1038	7447	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|axis axis|compound|END_ENTITY	Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma_multiforme .
8892096	0	CDR2	105,109	TCR	94,97	CDR2	TCR	1039	6962	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	MHC-restriction , cytokine profile , and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides : comparison with myelin_basic_protein-specific T cells .
11916170	0	CDR3	6,10	CD4	24,27	CDR3	CD4	8163	920	Gene	Gene	diversity|compound|START_ENTITY diversity|nmod|+ +|compound|END_ENTITY	TCRBV CDR3 diversity of CD4 + and CD8 + T-lymphocytes in HIV-infected individuals .
22070085	0	CDS	49,52	Atoh1	38,43	CDS	Atoh1	1040	500156(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The cloning and sequencing of SD rat Atoh1 gene CDS region -RSB- .
9806839	0	CDS	81,84	CDP-diacylglycerol_synthase	52,79	CDS	CDP-diacylglycerol synthase	132001	132001	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Isolation and chromosomal localization of two human CDP-diacylglycerol_synthase -LRB- CDS -RRB- genes .
12472658	0	CDSN	73,77	corneodesmosin	52,66	CDSN	corneodesmosin	1041	1041	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Psoriasis is associated with a SNP haplotype of the corneodesmosin gene -LRB- CDSN -RRB- .
15529278	0	CDSN	113,117	corneodesmosin	92,106	CDSN	corneodesmosin	1041	1041	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mapping of the major psoriasis-susceptibility locus -LRB- PSORS1 -RRB- in a 70-Kb interval around the corneodesmosin gene -LRB- CDSN -RRB- .
22574790	0	CDSN	106,110	corneodesmosin	90,104	CDSN	corneodesmosin	101109128	101109128	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Predictive mutational bioinformatic analysis of variation in the skin and wool associated corneodesmosin -LRB- CDSN -RRB- gene in sheep .
19054765	0	CDT1	6,10	CDC7	27,31	CDT1	CDC7	81620	8317	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Human CDT1 associates with CDC7 and recruits CDC45 to chromatin during S phase .
25744420	0	CDX-2	93,98	HNF-1a	99,105	CDX-2	HNF-1a	66019(Tax:10116)	24817(Tax:10116)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Thyroid and Glucocorticoid Hormones Induce Expression of Lactase-Phlorizin_Hydrolase Gene in CDX-2 / HNF-1a Co-Transfected IEC-6 Cells .
11871772	0	CDX1	50,54	CDX2	28,32	CDX1	CDX2	1044	1045	Gene	Gene	that|nmod|START_ENTITY precedes|dobj|that precedes|nsubj|Expression Expression|nmod|END_ENTITY	Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal_metaplasia .
19188603	0	CDX1	85,89	Cytokeratin_20	40,54	CDX1	Cytokeratin 20	1044	54474	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Gastrointestinal differentiation marker Cytokeratin_20 is regulated by homeobox gene CDX1 .
26307678	0	CDX2	32,36	Achaete_scute-like_2	0,20	CDX2	Achaete scute-like 2	1045	430	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Achaete_scute-like_2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation .
22076569	0	CDX2	55,59	BMP4	18,22	CDX2	BMP4	1045	652	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Activation of the BMP4 pathway and early expression of CDX2 characterize non-specialized columnar metaplasia in a human model of Barrett 's _ esophagus .
11871772	0	CDX2	28,32	CDX1	50,54	CDX2	CDX1	1045	1044	Gene	Gene	Expression|nmod|START_ENTITY precedes|nsubj|Expression precedes|dobj|that that|nmod|END_ENTITY	Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal_metaplasia .
16980943	0	CDX2	34,38	CK20	146,150	CDX2	CK20	1045	54474	Gene	Gene	expression|nmod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	Immunohistochemical expression of CDX2 in primary ovarian_mucinous_tumors and metastatic mucinous_carcinomas involving the ovary : comparison with CK20 and correlation with coordinate expression of CK7 .
15013430	0	CDX2	20,24	COX-2	35,40	CDX2	COX-2	1045	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Homeodomain protein CDX2 regulates COX-2 expression in colorectal_cancer .
23836438	0	CDX2	0,4	CT-1	66,70	CDX2	CT-1	618679(Tax:9913)	282367(Tax:9913)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|compound|END_ENTITY	CDX2 regulates multiple trophoblast genes in bovine trophectoderm CT-1 cells .
11997022	0	CDX2	97,101	Cdx1	15,19	CDX2	Cdx1	1045	1044	Gene	Gene	homeoprotein|compound|START_ENTITY effect|nmod|homeoprotein Stimulation|dep|effect Stimulation|nmod|END_ENTITY	Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon_cancer cells ; opposite effect of the CDX2 homeoprotein .
17876541	0	CDX2	17,21	Cox-2	30,35	CDX2	Cox-2	1045	5743	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|transcription transcription|compound|END_ENTITY	Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB .
23408853	0	CDX2	0,4	MEX3A	43,48	CDX2	MEX3A	12591(Tax:10090)	72640(Tax:10090)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	CDX2 regulation by the RNA-binding protein MEX3A : impact on intestinal differentiation and stemness .
12559945	0	CDX2	20,24	MUC2	51,55	CDX2	MUC2	1045	4583	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression .
17576890	0	CDX2	107,111	MUC2	86,90	CDX2	MUC2	1045	4583	Gene	Gene	concert|nmod|START_ENTITY END_ENTITY|nmod|concert	Pathogenesis of Barrett_esophagus : deoxycholic_acid up-regulates goblet-specific gene MUC2 in concert with CDX2 in human esophageal cells .
19266212	0	CDX2	90,94	MUC5AC	50,56	CDX2	MUC5AC	12591(Tax:10090)	17833(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Juvenile_polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4 .
23801117	0	CDX2	95,99	MiR-424	0,7	CDX2	MiR-424	1045	494336	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-424 regulates monocytic differentiation of human leukemia U937 cells by directly targeting CDX2 .
23133598	0	CDX2	63,67	Reg_IV	0,6	CDX2	Reg IV	1045	83998	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Reg_IV is a direct target of intestinal transcriptional factor CDX2 in gastric_cancer .
17182120	0	CDX2	53,57	TFF3	14,18	CDX2	TFF3	1045	7033	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of TFF3 expression by homeodomain protein CDX2 .
18353622	0	CDX2	111,115	cadherin-17	49,60	CDX2	cadherin-17	1045	1015	Gene	Gene	study|appos|START_ENTITY study|nmod|expression expression|nmod|END_ENTITY	A clinicopathological study on the expression of cadherin-17 and caudal-related_homeobox_transcription_factor -LRB- CDX2 -RRB- in human gastric_carcinoma .
12404231	0	CDX2	0,4	liver_intestine-cadherin	15,39	CDX2	liver intestine-cadherin	1045	1015	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	CDX2 regulates liver_intestine-cadherin expression in normal and malignant colon epithelium and intestinal_metaplasia .
20699370	0	CDX2	0,4	multidrug_resistance_1	15,37	CDX2	multidrug resistance 1	1045	5243	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	CDX2 regulates multidrug_resistance_1 gene expression in malignant intestinal epithelium .
27060927	0	CDX2	51,55	multidrug_resistance_1	14,36	CDX2	multidrug resistance 1	1045	5243	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of multidrug_resistance_1 expression by CDX2 in ovarian_mucinous_adenocarcinoma .
19449081	0	CDX2	39,43	nucleostemin	14,26	CDX2	nucleostemin	1045	26354	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of nucleostemin upregulates CDX2 expression in HT29 cells in response to bile_acid exposure : implications in the pathogenesis of Barrett 's _ esophagus .
21471217	0	CDX4	17,21	HOXA10	55,61	CDX4	HOXA10	1046	3206	Gene	Gene	transcription|compound|START_ENTITY activates|nsubj|transcription activates|dobj|transcription transcription|nummod|END_ENTITY	HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells .
21471217	0	CDX4	17,21	HoxA10	0,6	CDX4	HoxA10	1046	3206	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells .
25531430	0	CDX4	14,18	HoxA9	41,46	CDX4	HoxA9	1046	3205	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of CDX4 gene transcription by HoxA9 , HoxA10 , the Mll-Ell oncogene and Shp2 during leukemogenesis .
17573145	0	CDYL	82,86	chromodomain_Y-like	61,80	CDYL	chromodomain Y-like	9425	9425	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Functional consequences of new exon acquisition in mammalian chromodomain_Y-like -LRB- CDYL -RRB- genes .
8392520	0	CD_10	59,64	common_acute_lymphoblastic_leukemia_antigen	14,57	CD 10	common acute lymphoblastic leukemia antigen	4311	4311	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of common_acute_lymphoblastic_leukemia_antigen -LRB- CD_10 -RRB- by myelinated fibers of the peripheral nervous system .
14513377	0	CD_117	76,82	KIT	71,74	CD 117	KIT	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Sequence analysis and high-throughput immunohistochemical profiling of KIT -LRB- CD_117 -RRB- expression in uveal_melanoma using tissue_microarrays .
26416056	0	CD_117	21,27	c-kit	14,19	CD 117	c-kit	3815	3815	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Evaluation of c-kit -LRB- CD_117 -RRB- expression as a prognostic factor in testicular_germ_cell_tumors : an Izmir Oncology Group -LRB- IZOG -RRB- study .
18248531	0	CD_127	0,6	CD25	33,37	CD 127	CD25	3575	3669	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	CD_127 - and FoxP3 + expression on CD25 + CD4 + T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type_1_diabetes_mellitus patients .
18248531	0	CD_127	0,6	CD4	38,41	CD 127	CD4	3575	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	CD_127 - and FoxP3 + expression on CD25 + CD4 + T regulatory cells upon specific diabetogeneic stimulation in high-risk relatives of type_1_diabetes_mellitus patients .
8724651	0	CD_16	61,66	Fc_gamma_RIII	46,59	CD 16	Fc gamma RIII	2214	2214	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Extremely_low_birth_weight infants have lower Fc_gamma_RIII -LRB- CD_16 -RRB- plasma levels and their PMN produce less Fc_gamma_RIII compared to adults .
10891891	0	CD_20	32,37	TNF_alpha	108,117	CD 20	TNF alpha	54474	7124	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Tumor_necrosis_factor modulates CD_20 expression on cells from chronic_lymphocytic_leukemia : a new role for TNF_alpha ?
10891891	0	CD_20	32,37	Tumor_necrosis_factor	0,21	CD 20	Tumor necrosis factor	54474	7124	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Tumor_necrosis_factor modulates CD_20 expression on cells from chronic_lymphocytic_leukemia : a new role for TNF_alpha ?
2524204	0	CD_21	101,106	CR2	96,99	CD 21	CR2	1380	1380	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Enhanced binding of immune complexes processed by erythrocyte CR1 -LRB- CD_35 -RRB- receptors to purified CR2 -LRB- CD_21 -RRB- receptors from tonsillar mononuclear cells .
23252864	0	CD_25	20,25	CD4	16,19	CD 25	CD4	3559	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Crucial role of CD4 + CD_25 + FOXP3 + T regulatory cell , interferon-y and interleukin-16 in malignant and tuberculous_pleural_effusions .
23252864	0	CD_25	20,25	FOXP3	27,32	CD 25	FOXP3	3559	50943	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Crucial role of CD4 + CD_25 + FOXP3 + T regulatory cell , interferon-y and interleukin-16 in malignant and tuberculous_pleural_effusions .
3034662	0	CD_25	14,19	Tac_antigen	21,32	CD 25	Tac antigen	3559	3559	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CD_25 -LRB- Tac_antigen -RRB- in lymphoid_leukemias and non-Hodgkin_lymphomas .
2787420	0	CD_4	20,24	Leu_7	27,32	CD 4	Leu 7	920	27087	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- A novel phenotype -LRB- CD_4 + , Leu_7 + -RRB- in large_granular_lymphocyte_leukemia : a case report -RSB- .
11677954	0	CD_94	24,29	Kp43	18,22	CD 94	Kp43	3824	3824	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Expression of the Kp43 -LRB- CD_94 -RRB- receptor by natural killer -LRB- NK -RRB- cells in ulcerative_colitis .
11401336	0	CD_95	30,35	fas_antigen	17,28	CD 95	fas antigen	355	355	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Possible role of fas_antigen -LRB- CD_95 -RRB- in human_amniotic_epithelial cell death : an in vitro study .
8204885	0	CDw127	92,98	IL-7	99,103	CDw127	IL-7	3575	3574	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Growth inhibitory and agonistic signals of interleukin-7 -LRB- IL-7 -RRB- can be mediated through the CDw127 IL-7 receptor .
9175915	0	CDw127	39,45	IL-7	107,111	CDw127	IL-7	3575	3574	Gene	Gene	indicates|nsubj|START_ENTITY IL-7_receptor|acl:relcl|indicates Absence|nmod|IL-7_receptor insufficient|nsubj|Absence insufficient|nmod|END_ENTITY	Absence of the IL-7_receptor component CDw127 indicates that gamma -LRB- c -RRB- expression alone is insufficient for IL-7 to modulate human neutrophil responses .
11160657	0	CDw150	24,30	SLAM	18,22	CDw150	SLAM	6504	6504	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	V domain of human SLAM -LRB- CDw150 -RRB- is essential for its function as a measles_virus receptor .
3257976	0	CDw40	60,65	Bp50	67,71	CDw40	Bp50	958	474207	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Resting B lymphocytes can be triggered directly through the CDw40 -LRB- Bp50 -RRB- antigen .
3500063	0	CDw40	61,66	interleukin_4	32,45	CDw40	interleukin 4	958	3565	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Synergistic interaction between interleukin_4 and anti-Bp50 -LRB- CDw40 -RRB- revealed in a novel B cell restimulation assay .
9261475	0	CDw50	49,54	intercellular_adhesion_molecule_3	14,47	CDw50	intercellular adhesion molecule 3	3385	3385	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule_3 -LRB- CDw50 -RRB- on endothelial cells in cutaneous_lymphomas .
9028155	0	CDw90	1,6	CD34	29,33	CDw90	CD34	7070	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	-LSB- CDw90 -LRB- Thy-1 -RRB- expression on CD34 positive cells in peripheral blood stem cell harvest -RSB- .
7540889	0	CDw90	27,32	Thy-1	20,25	CDw90	Thy-1	7070	7070	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Characterization of Thy-1 -LRB- CDw90 -RRB- expression in CD34 + acute_leukemia .
9028155	0	CDw90	1,6	Thy-1	8,13	CDw90	Thy-1	7070	7070	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- CDw90 -LRB- Thy-1 -RRB- expression on CD34 positive cells in peripheral blood stem cell harvest -RSB- .
12242516	0	CEA	36,39	A24	83,86	CEA	A24	1084	28924	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Induction of specific CTL by MAGE-3 / CEA peptide-pulsed dendritic cells from HLA-A2 / A24 -LRB- + -RRB- gastrointestinal_cancer patients .
26976996	0	CEA	46,49	AFP	52,55	CEA	AFP	1084	174	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	Prognostic Value of Carcinoembryonic_Antigen -LRB- CEA -RRB- , AFP , CA19-9 and CA125 for Patients with Colorectal_Cancer with Peritoneal_Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy .
10770115	0	CEA	0,3	CA125	5,10	CEA	CA125	1084	94025	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	CEA , CA125 and CA19-9 levels in congenital_gastrointestinal_anomalies .
18609108	0	CEA	50,53	CA125	56,61	CEA	CA125	1084	94025	Gene	Gene	carcinoembryonic_antigen|appos|START_ENTITY intervals|nmod|carcinoembryonic_antigen intervals|appos|END_ENTITY	Reference intervals for carcinoembryonic_antigen -LRB- CEA -RRB- , CA125 , MUC1 , Alfa-foeto-protein -LRB- AFP -RRB- , neuron-specific_enolase -LRB- NSE -RRB- and CA19 .9 from the NORIP study .
19383238	0	CEA	48,51	CA125	74,79	CEA	CA125	1084	94025	Gene	Gene	carcinoembryonic_antigen|appos|START_ENTITY efficacy|nmod|carcinoembryonic_antigen efficacy|appos|antigen antigen|dep|125 125|appos|END_ENTITY	The efficacy of serum carcinoembryonic_antigen -LRB- CEA -RRB- , cancer antigen 125 -LRB- CA125 -RRB- , carbohydrate antigen 19-9 -LRB- CA19-9 -RRB- , carbohydrate_antigen_15-3 -LRB- CA15-3 -RRB- , alpha-fetoprotein -LRB- AFP -RRB- and human chorionic_gonadotropin _ -LRB- hCG -RRB- levels in determining the malignancy of solitary_pulmonary_nodules .
3165255	0	CEA	181,184	CA125	110,115	CEA	CA125	1084	94025	Gene	Gene	_|appos|START_ENTITY cultures|dobj|_ cultures|appos|END_ENTITY	Experiments with tissue cultures from a human ovarian_serous_cystadenocarcinoma producing cancer antigen 125 -LRB- CA125 -RRB- , tissue_polypeptide_antigen _ -LRB- TPA -RRB- _ and_carcinoembryonic_antigen _ -LRB- CEA -RRB- .
8690294	0	CEA	33,36	CA125	18,23	CEA	CA125	1084	94025	Gene	Gene	CA72-4|appos|START_ENTITY CA72-4|compound|END_ENTITY	Clinical value of CA125 , CA19-9 , CEA , CA72-4 , and TPA_in_borderline_ovarian_tumor .
22330621	0	CEA	89,92	CAS	24,27	CEA	CAS	5670	9564	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	Immediate conversion to CAS after neurological intolerance at cross-clamping test during CEA : a preliminary experience .
2255409	0	CEA	25,28	CA_15-3	1,8	CEA	CA 15-3	1084	4582	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	-LSB- CA_15-3 associated with CEA and TPA in the follow-up of breast_carcinoma -RSB- .
2733831	0	CEA	94,97	CA_15-3	1,8	CEA	CA 15-3	1084	4582	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- CA_15-3 in the diagnosis and monitoring of carcinoma_of_the_breast and its correlations with CEA -RSB- .
19657698	0	CEA	34,37	CEA	97,100	CEA	CEA	1084	1084	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Prognostic value of postoperative CEA clearance in rectal_cancer patients with high preoperative CEA levels .
19657698	0	CEA	97,100	CEA	34,37	CEA	CEA	1084	1084	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Prognostic value of postoperative CEA clearance in rectal_cancer patients with high preoperative CEA levels .
24783267	0	CEA	45,48	CEA	68,71	CEA	CEA	1084	1084	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Evaluating the significance of expression of CEA mRNA and levels of CEA and its related proteins in colorectal_cancer patients .
24783267	0	CEA	68,71	CEA	45,48	CEA	CEA	1084	1084	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Evaluating the significance of expression of CEA mRNA and levels of CEA and its related proteins in colorectal_cancer patients .
22195770	0	CEA	117,120	CEACAM7	22,29	CEA	CEACAM7	1048	1087	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Dynamic expression of CEACAM7 in precursor lesions of gastric_carcinoma and its prognostic value in combination with CEA .
12743424	0	CEA	14,17	CSAp	19,23	CEA	CSAp	1084	1161	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Colonic_tumor CEA , CSAp and MUC-1 expression following radioimmunotherapy or chemotherapy .
26976996	0	CEA	46,49	Carcinoembryonic_Antigen	20,44	CEA	Carcinoembryonic Antigen	1084	1084	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	Prognostic Value of Carcinoembryonic_Antigen -LRB- CEA -RRB- , AFP , CA19-9 and CA125 for Patients with Colorectal_Cancer with Peritoneal_Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy .
1000475	0	CEA	26,29	Carcinoembryonic_antigen	0,24	CEA	Carcinoembryonic antigen	1084	1084	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Carcinoembryonic_antigen -LRB- CEA -RRB- activity in pancreatic juice of patients with pancreatic_carcinoma and pancreatitis .
3545047	0	CEA	26,29	Carcinoembryonic_antigen	0,24	CEA	Carcinoembryonic antigen	1084	1084	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Carcinoembryonic_antigen -LRB- CEA -RRB- expression in early embryogenesis : a study of the first trimester of gestation .
3807878	0	CEA	27,30	Carcinoembryonic_antigen	1,25	CEA	Carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Carcinoembryonic_antigen -LRB- CEA -RRB- levels of peripheral and portal blood and tumor histopathology in colorectal_cancer -RSB- .
6365131	0	CEA	26,29	Carcinoembryonic_antigen	0,24	CEA	Carcinoembryonic antigen	1084	1084	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Carcinoembryonic_antigen -LRB- CEA -RRB- expression and heterogeneity in primary and autologous metastatic gastric_tumours demonstrated by a monoclonal antibody .
6604368	0	CEA	27,30	Carcinoembryonic_antigen	1,25	CEA	Carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Carcinoembryonic_antigen -LRB- CEA -RRB- levels and their clinical significance in Crohn 's _ disease -RSB- .
16243831	0	CEA	80,83	HLA-A	28,33	CEA	HLA-A	1084	3105	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	More efficient induction of HLA-A * 0201-restricted and carcinoembryonic_antigen -LRB- CEA -RRB- - specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells .
10745140	0	CEA	70,73	MRI	20,23	CEA	MRI	5670	78996	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Ferumoxide-enhanced MRI in patients with colorectal_cancer and rising CEA : surgical correlation in early recurrence .
18609108	0	CEA	50,53	MUC1	63,67	CEA	MUC1	1084	4582	Gene	Gene	carcinoembryonic_antigen|appos|START_ENTITY intervals|nmod|carcinoembryonic_antigen intervals|appos|END_ENTITY	Reference intervals for carcinoembryonic_antigen -LRB- CEA -RRB- , CA125 , MUC1 , Alfa-foeto-protein -LRB- AFP -RRB- , neuron-specific_enolase -LRB- NSE -RRB- and CA19 .9 from the NORIP study .
3037205	0	CEA	107,110	Neuron-specific_enolase	0,23	CEA	Neuron-specific enolase	1084	2026	Gene	Gene	carcinoembryonic_antigen|appos|START_ENTITY marker|nmod|carcinoembryonic_antigen END_ENTITY|nmod|marker	Neuron-specific_enolase -LRB- NSE -RRB- as a tumour marker and comparative evaluation with carcinoembryonic_antigen -LRB- CEA -RRB- in small-cell_lung_cancer .
3429947	0	CEA	98,101	Neuron-specific_enolase	0,23	CEA	Neuron-specific enolase	1084	2026	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Neuron-specific_enolase in the diagnosis and therapy monitoring of lung_cancer : a comparison with CEA , TPA , ferritin and calcitonin .
1351108	0	CEA	181,184	P-glycoprotein	63,77	CEA	P-glycoprotein	1084	5243	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Immunohistochemical detection of carcinoembryonic_antigen and P-glycoprotein in small_cell_lung_cancer at diagnosis and relapse , with special reference to the tissue expression of CEA and response to chemotherapy -RSB- .
2693562	0	CEA	12,15	TPA_and_CA_19-9	17,32	CEA	TPA and CA 19-9	1084	5327	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of CEA , TPA_and_CA_19-9 in the early detection of recurrent colorectal_cancer .
24697115	0	CEA	57,60	YKL-40	45,51	CEA	YKL-40	1084	1116	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of combined testing of YKL-40 with CEA in Chinese colorectal_cancer patients .
10574697	0	CEA	40,43	carcinoembryonic_antigen	14,38	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of carcinoembryonic_antigen -LRB- CEA -RRB- N-A3 domain in Pichia_pastoris by fermentation .
10690602	0	CEA	35,38	carcinoembryonic_antigen	9,33	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Elevated carcinoembryonic_antigen -LRB- CEA -RRB- levels in a patient with no malignancy .
11273768	0	CEA	63,66	carcinoembryonic_antigen	37,61	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Augmenting transgene expression from carcinoembryonic_antigen -LRB- CEA -RRB- promoter via a GAL4 gene regulatory system .
11712806	0	CEA	46,49	carcinoembryonic_antigen	20,44	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of carcinoembryonic_antigen -LRB- CEA -RRB- in tumor tissue of patients with colorectal_cancer .
11939491	0	CEA	57,60	carcinoembryonic_antigen	31,55	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Intermethod variation in serum carcinoembryonic_antigen -LRB- CEA -RRB- measurement .
11964079	0	CEA	51,54	carcinoembryonic_antigen	25,49	CEA	carcinoembryonic antigen	111518(Tax:10090)	111518(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of endogenous carcinoembryonic_antigen -LRB- CEA -RRB- increases the apoptotic rate of colon_cancer cells and inhibits metastatic_tumor growth .
1260660	1	CEA	56,59	carcinoembryonic_antigen	30,54	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Abnormal carcinoembryonic_antigen -LRB- CEA -RRB- levels in asymptomatic retinoblastoma family members .
1327687	0	CEA	52,55	carcinoembryonic_antigen	26,50	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- The relationship between carcinoembryonic_antigen -LRB- CEA -RRB- expression and histogenesis of gastric_cancer -LRB- application of immunohistochemical and mucin histochemical techniques -RRB- -RSB- .
1546571	0	CEA	110,113	carcinoembryonic_antigen	84,108	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	-LSB- A case of transitional_cell_carcinoma of renal pelvis with an extremely high serum carcinoembryonic_antigen -LRB- CEA -RRB- level -RSB- .
1567173	0	CEA	58,61	carcinoembryonic_antigen	32,56	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Serum sialic_acid -LRB- TSA/LSA -RRB- and carcinoembryonic_antigen -LRB- CEA -RRB- levels in cancer patients undergoing radiotherapy .
1625062	0	CEA	51,54	carcinoembryonic_antigen	25,49	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Membranous expression of carcinoembryonic_antigen -LRB- CEA -RRB- in the normal cervical squamous_mucosa .
18604735	0	CEA	55,58	carcinoembryonic_antigen	29,53	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Protein expression levels of carcinoembryonic_antigen -LRB- CEA -RRB- in Danish ovarian_cancer patients : from the Danish _ ` MALOVA'ovarian _ cancer study .
18630484	0	CEA	61,64	carcinoembryonic_antigen	35,59	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	Diminishing impact of preoperative carcinoembryonic_antigen -LRB- CEA -RRB- in prognosis of Dukes ' C colorectal_cancer .
19068780	0	CEA	83,86	carcinoembryonic_antigen	57,81	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Recurrence pattern and rapid intraoperative detection of carcinoembryonic_antigen -LRB- CEA -RRB- mRNA in pleural_lavage in patients with non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
2065318	0	CEA	66,69	carcinoembryonic_antigen	35,59	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regional chromosomal assignment of carcinoembryonic_antigen gene -LRB- CEA -RRB- to chromosome 19 at band q13 .2 .
2133556	0	CEA	62,65	carcinoembryonic_antigen	36,60	CEA	carcinoembryonic antigen	111518(Tax:10090)	111518(Tax:10090)	Gene	Gene	members|appos|START_ENTITY members|amod|END_ENTITY	Spatiotemporal expression of murine carcinoembryonic_antigen -LRB- CEA -RRB- gene family members during mouse embryogenesis .
25697175	0	CEA	42,45	carcinoembryonic_antigen	16,40	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of carcinoembryonic_antigen -LRB- CEA -RRB- in patients with bipolar_disorder .
2685416	0	CEA	36,39	carcinoembryonic_antigen	10,34	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Study|appos|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study of carcinoembryonic_antigen -LRB- CEA -RRB- in the epidermis of psoriasis_vulgaris -RSB- .
2845551	0	CEA	55,58	carcinoembryonic_antigen	29,53	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of carcinoembryonic_antigen -LRB- CEA -RRB- in lung_carcinoma by five monoclonal antibodies .
3026253	0	CEA	120,123	carcinoembryonic_antigen	94,118	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Serum neuron-specific_enolase -LRB- NSE -RRB- in patients with small cell lung_cancer -- comparison with carcinoembryonic_antigen -LRB- CEA -RRB- -RSB- .
3046676	0	CEA	60,63	carcinoembryonic_antigen	34,58	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	-LSB- Immunohistochemical study of the carcinoembryonic_antigen -LRB- CEA -RRB- in human tumors using the CEA-specific oncoprecipitin crustacin -RSB- .
3397719	0	CEA	42,45	carcinoembryonic_antigen	16,40	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	-LSB- Correlation of carcinoembryonic_antigen -LRB- CEA -RRB- content in resected tissue with serum CEA levels in patients with gastric_carcinoma -RSB- .
3513695	0	CEA	58,61	carcinoembryonic_antigen	32,56	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of carcinoembryonic_antigen -LRB- CEA -RRB- on ultrathin cryosections of human tumours .
3522636	0	CEA	43,46	carcinoembryonic_antigen	17,41	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Demonstration of carcinoembryonic_antigen -LRB- CEA -RRB- expression in normal , chronically inflamed , and malignant pancreatic tissue by immunohistochemistry .
3681244	0	CEA	42,45	carcinoembryonic_antigen	16,40	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	-LSB- Correlation of carcinoembryonic_antigen -LRB- CEA -RRB- content in the resected tissue with the serum CEA levels in patients with colorectal_carcinoma -RSB- .
4057566	0	CEA	66,69	carcinoembryonic_antigen	40,64	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	-LSB- Evaluation of the measurement of serum carcinoembryonic_antigen -LRB- CEA -RRB- levels using monoclonal antibody -RSB- .
498010	0	CEA	46,49	carcinoembryonic_antigen	20,44	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The value of serial carcinoembryonic_antigen -LRB- CEA -RRB- in predicting response rate and survival of patients with gastrointestinal_cancer treated with chemotherapy .
6262678	0	CEA	40,43	carcinoembryonic_antigen	14,38	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Assay|appos|START_ENTITY Assay|nmod|END_ENTITY	-LSB- Assay of the carcinoembryonic_antigen -LRB- CEA -RRB- in acute and chronic liver_diseases and hepatocellular_carcinoma -RSB- .
6296267	0	CEA	37,40	carcinoembryonic_antigen	11,35	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of carcinoembryonic_antigen -LRB- CEA -RRB- to an anti-CEA immunosorbent in the presence of detergents .
6446377	0	CEA	67,70	carcinoembryonic_antigen	41,65	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	The use and limitations of serial plasma carcinoembryonic_antigen -LRB- CEA -RRB- levels as a monitor of changing metastatic liver_tumor volume in patients receiving chemotherapy .
6506227	0	CEA	46,49	carcinoembryonic_antigen	20,44	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Diagnostic value of carcinoembryonic_antigen -LRB- CEA -RRB- assay in pleural_effusions .
6537552	0	CEA	42,45	carcinoembryonic_antigen	16,40	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	-LSB- High levels of carcinoembryonic_antigen -LRB- CEA -RRB- in the serum of uremic patients under hemodialysis treatment -RSB- .
6839982	0	CEA	48,51	carcinoembryonic_antigen	22,46	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of the carcinoembryonic_antigen -LRB- CEA -RRB- for predicting the success of therapy in metastatic breast_cancer -RSB- .
7021564	0	CEA	38,41	carcinoembryonic_antigen	12,36	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of carcinoembryonic_antigen -LRB- CEA -RRB- in the normal and inflamed human parotid gland .
7148317	0	CEA	51,54	carcinoembryonic_antigen	25,49	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of carcinoembryonic_antigen -LRB- CEA -RRB- in patients with adenocarcinoma in colon_and_rectum .
7357243	0	CEA	85,88	carcinoembryonic_antigen	59,83	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	The clinical significance of the pattern of elevated serum carcinoembryonic_antigen -LRB- CEA -RRB- levels in recurrent colorectal_cancer .
7426321	0	CEA	57,60	carcinoembryonic_antigen	31,55	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The diagnostic value of plasma carcinoembryonic_antigen -LRB- CEA -RRB- in pancreatic_disease .
7460983	0	CEA	67,70	carcinoembryonic_antigen	41,65	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The clinical value of plasma and urinary carcinoembryonic_antigen -LRB- CEA -RRB- assays in patients with haematuria and urothelial_carcinoma .
81670	0	CEA	75,78	carcinoembryonic_antigen	49,73	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Physicochemical and immunochemical properties of carcinoembryonic_antigen -LRB- CEA -RRB- from different tumour sources .
817166	0	CEA	44,47	carcinoembryonic_antigen	18,42	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of carcinoembryonic_antigen -LRB- CEA -RRB- in patients with tumors of the large intestine .
837050	0	CEA	63,66	carcinoembryonic_antigen	37,61	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The clinical diagnostic value of the carcinoembryonic_antigen -LRB- CEA -RRB- in haematuria .
8689623	0	CEA	89,92	carcinoembryonic_antigen	63,87	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A colorimetric immunoassay for the detection of E-cadherin and carcinoembryonic_antigen -LRB- CEA -RRB- expression on human colon_carcinoma cell lines in vitro .
8919110	0	CEA	62,65	carcinoembryonic_antigen	36,60	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	localisation|appos|START_ENTITY localisation|nmod|END_ENTITY	Immunohistochemical localisation of carcinoembryonic_antigen -LRB- CEA -RRB- in malignant_epithelial_ovarian_tumours using monoclonal antibodies .
947865	0	CEA	36,39	carcinoembryonic_antigen	10,34	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	-LSB- Value of carcinoembryonic_antigen -LRB- CEA -RRB- in the diagnosis of malignant_tumors of the urogenital tract -RSB- .
9673116	0	CEA	45,48	carcinoembryonic_antigen	19,43	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	-LSB- The evaluation of carcinoembryonic_antigen -LRB- CEA -RRB- levels in patients with laryngeal_cancer -RSB- .
9832303	0	CEA	72,75	carcinoembryonic_antigen	46,70	CEA	carcinoembryonic antigen	1084	1084	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Solid-phase synthesis and characterization of carcinoembryonic_antigen -LRB- CEA -RRB- domains .
15816515	0	CEA	23,26	hnRNP_M4	38,46	CEA	hnRNP M4	1084	4670	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Surface expression and CEA binding of hnRNP_M4 protein in HT29 colon_cancer cells .
3026253	0	CEA	120,123	neuron-specific_enolase	7,30	CEA	neuron-specific enolase	1084	2026	Gene	Gene	-RSB-|appos|START_ENTITY comparison|nmod|-RSB- END_ENTITY|dep|comparison	-LSB- Serum neuron-specific_enolase -LRB- NSE -RRB- in patients with small cell lung_cancer -- comparison with carcinoembryonic_antigen -LRB- CEA -RRB- -RSB- .
3039284	0	CEA	75,78	p21	40,43	CEA	p21	1048	644914	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of ras p21 and carcinoembryonic antigens -LRB- CEA -RRB- in cholangiocarcinoma .
3263130	0	CEA	101,104	pregnancy-specific_beta_1-glycoprotein	39,77	CEA	pregnancy-specific beta 1-glycoprotein	5670	5673	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Exon-intron organization of a gene for pregnancy-specific_beta_1-glycoprotein , a subfamily member of CEA family : implications for its characteristic repetitive domains and C-terminal sequences .
22496641	0	CEACAM1	0,7	IL-1b	29,34	CEACAM1	IL-1b	634	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	CEACAM1 negatively regulates IL-1b production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex .
15956076	0	CEACAM1	54,61	Osteopontin	0,11	CEACAM1	Osteopontin	634	6696	Gene	Gene	colocalized|nmod|START_ENTITY colocalized|nsubjpass|END_ENTITY	Osteopontin is colocalized with the adhesion molecule CEACAM1 in the extravillous trophoblast of the human placenta and enhances invasion of CEACAM1-expressing placental cells .
18794798	0	CEACAM1	0,7	SOX9	11,15	CEACAM1	SOX9	634	6662	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	CEACAM1 , a SOX9 direct transcriptional target identified in the colon epithelium .
26885752	0	CEACAM1	26,33	SOX9	0,4	CEACAM1	SOX9	634	6662	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SOX9 indirectly regulates CEACAM1 expression and immune resistance in melanoma cells .
24931667	0	CEACAM1	0,7	Sox-2	46,51	CEACAM1	Sox-2	634	6657	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	CEACAM1 promotes melanoma cell growth through Sox-2 .
14522961	0	CEACAM1	0,7	annexin_II	65,75	CEACAM1	annexin II	634	302	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	CEACAM1 , a cell-cell adhesion molecule , directly associates with annexin_II in a three-dimensional model of mammary morphogenesis .
23499736	0	CEACAM1	0,7	b-catenin	84,93	CEACAM1	b-catenin	634	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with b-catenin .
15339048	0	CEACAM1	28,35	beta1_integrin	95,109	CEACAM1	beta1 integrin	634	3688	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1_integrin in a 3D model of morphogenesis .
21398516	0	CEACAM1	82,89	carcinoembryonic_antigen-related_cell_adhesion_molecule-1	23,80	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule-1	634	634	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Mechanistic control of carcinoembryonic_antigen-related_cell_adhesion_molecule-1 -LRB- CEACAM1 -RRB- splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L , hnRNP_A1 , and hnRNP_M .
21669871	0	CEACAM1	85,92	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	26,83	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1	634	634	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Interaction of actin with carcinoembryonic_antigen-related_cell_adhesion_molecule_1 -LRB- CEACAM1 -RRB- receptor in liposomes is Ca2 + - and phospholipid-dependent .
16291724	0	CEACAM1	0,7	filamin_A	36,45	CEACAM1	filamin A	634	2316	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CEACAM1 functionally interacts with filamin_A and exerts a dual role in the regulation of cell migration .
11035932	0	CEACAM1	23,30	paxillin	47,55	CEACAM1	paxillin	634	5829	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells .
17339478	0	CEACAM3	84,91	Vav	118,121	CEACAM3	Vav	1084	7409	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 -LRB- CEACAM3 -RRB- directly associates with Vav to promote phagocytosis of human pathogens .
26974538	0	CEACAM6	83,90	Carcinoembryonic_Antigen-Related_Cellular_Adhesion_Molecule_6	20,81	CEACAM6	Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6	4680	4680	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Biliary Carcinoembryonic_Antigen-Related_Cellular_Adhesion_Molecule_6 -LRB- CEACAM6 -RRB- as a Biomarker in Cholangiocarcinoma .
22195770	0	CEACAM7	22,29	CEA	117,120	CEACAM7	CEA	1087	1048	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Dynamic expression of CEACAM7 in precursor lesions of gastric_carcinoma and its prognostic value in combination with CEA .
25779641	0	CEBPB	8,13	C/EBPb	0,6	CEBPB	C/EBPb	1051	1051	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	C/EBPb -LRB- CEBPB -RRB- protein binding to the C/EBP CRE DNA 8-mer TTGC GTCA is inhibited by 5hmC and enhanced by 5mC , 5fC , and 5caC in the CG dinucleotide .
21980073	0	CEBPD	0,5	prolactin	17,26	CEBPD	prolactin	25695(Tax:10116)	24683(Tax:10116)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	CEBPD suppresses prolactin expression and prolactinoma cell proliferation .
9753320	0	CED-4	7,12	Apaf1	0,5	CED-4	Apaf1	317	317	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Apaf1 -LRB- CED-4 homolog -RRB- regulates programmed cell death in mammalian development .
9027313	0	CED-4	58,63	CED-9	67,72	ced-4	CED-9	175643(Tax:6239)	3565776(Tax:6239)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction and regulation of subcellular localization of CED-4 by CED-9 .
9837929	0	CED-4	68,73	CED-9	57,62	CED-4	CED-9	175643(Tax:6239)	3565776(Tax:6239)	Gene	Gene	disrupts|nmod|START_ENTITY disrupts|dobj|interaction interaction|nmod|END_ENTITY	Caenorhabditis_elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation .
10846174	1	CED-4	24,29	EGL-1	41,46	CED-4	EGL-1	175643(Tax:6239)	179943(Tax:6239)	Gene	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis_elegans .
21490059	0	CED-5-CED-12	89,101	MTM-1	33,38	CED-5-CED-12	MTM-1	177942;172890	172148(Tax:6239)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. _ elegans .
9027313	0	CED-9	67,72	CED-4	58,63	CED-9	ced-4	3565776(Tax:6239)	175643(Tax:6239)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction and regulation of subcellular localization of CED-4 by CED-9 .
9837929	0	CED-9	57,62	CED-4	68,73	CED-9	CED-4	3565776(Tax:6239)	175643(Tax:6239)	Gene	Gene	interaction|nmod|START_ENTITY disrupts|dobj|interaction disrupts|nmod|END_ENTITY	Caenorhabditis_elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation .
9604928	0	CED-9	109,114	EGL-1	23,28	CED-9	EGL-1	3565776(Tax:6239)	179943(Tax:6239)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The C. _ elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9 .
9837929	0	CED-9	57,62	EGL-1	23,28	CED-9	EGL-1	3565776(Tax:6239)	179943(Tax:6239)	Gene	Gene	interaction|nmod|START_ENTITY disrupts|dobj|interaction disrupts|nsubj|END_ENTITY	Caenorhabditis_elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation .
11053466	0	CEF	0,3	sec24	7,12	CEF	sec24	823559(Tax:3702)	854697(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|amod|END_ENTITY	CEF , a sec24 homologue of Arabidopsis_thaliana , enhances the survival of yeast under oxidative stress conditions .
24690231	0	CEH-28	0,6	dbl-1	17,22	CEH-28	dbl-1	191619(Tax:6239)	179068(Tax:6239)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	CEH-28 activates dbl-1 expression and TGF-b signaling in the C. _ elegans M4 neuron .
19760265	0	CEL	57,60	carboxyl-ester_lipase	29,50	CEL	carboxyl-ester lipase	1056	1056	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the VNTR of the carboxyl-ester_lipase gene -LRB- CEL -RRB- are a rare cause of monogenic diabetes .
23395566	0	CEL	59,62	carboxyl-ester_lipase	36,57	CEL	carboxyl-ester lipase	1056	1056	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The number of tandem repeats in the carboxyl-ester_lipase -LRB- CEL -RRB- gene as a risk factor in alcoholic and idiopathic_chronic_pancreatitis .
1639390	0	CEL	106,109	carboxyl_ester_lipase	83,104	CEL	carboxyl ester lipase	1056	1056	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization , sequence analysis , and chromosomal localization of the human carboxyl_ester_lipase -LRB- CEL -RRB- gene and a CEL-like -LRB- CELL -RRB- gene .
15609224	0	CEM15	29,34	APOBEC3G	36,44	CEM15	APOBEC3G	60489	60489	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Exhaustive genotyping of the CEM15 -LRB- APOBEC3G -RRB- gene and absence of association with AIDS progression in a French cohort .
14667408	0	CENP-A	0,6	Aurora-A	26,34	CENP-A	Aurora-A	1058	6790	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function .
24469636	0	CENP-A	23,29	CAL1	0,4	CENP-A	CAL1	36495(Tax:7227)	42065(Tax:7227)	Gene	Gene	factor|compound|START_ENTITY factor|nsubj|END_ENTITY	CAL1 is the Drosophila CENP-A assembly factor .
26151904	0	CENP-A	46,52	CAL1	69,73	CENP-A	CAL1	36495(Tax:7227)	42065(Tax:7227)	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription .
19410545	0	CENP-A	69,75	HJURP	0,5	CENP-A	HJURP	1058	55355	Gene	Gene	maintenance|nmod|START_ENTITY maintenance|nsubj|END_ENTITY	HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres .
20080577	0	CENP-A	12,18	HJURP	0,5	CENP-A	HJURP	1058	55355	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres .
21321101	0	CENP-A	48,54	HJURP	8,13	CENP-A	HJURP	735079(Tax:8355)	100861527	Gene	Gene	assembly|amod|START_ENTITY required|nmod|assembly required|nsubjpass|END_ENTITY	Xenopus HJURP and condensin II are required for CENP-A assembly .
21768289	0	CENP-A	11,17	HJURP	0,5	CENP-A	HJURP	1058	55355	Gene	Gene	factor|amod|START_ENTITY factor|nsubj|END_ENTITY	HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore .
22406139	0	CENP-A	20,26	HJURP	0,5	CENP-A	HJURP	1058	55355	Gene	Gene	surfaces|amod|START_ENTITY uses|dobj|surfaces uses|nsubj|END_ENTITY	HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly .
23792427	0	CENP-A	46,52	HJURP	20,25	CENP-A	HJURP	1058	55355	Gene	Gene	assembly|amod|START_ENTITY drives|dobj|assembly drives|nsubj|dimerization dimerization|compound|END_ENTITY	How two become one : HJURP dimerization drives CENP-A assembly .
25001279	0	CENP-A	101,107	HJURP	35,40	CENP-A	HJURP	1058	55355	Gene	Gene	loading|appos|START_ENTITY recruitment|nmod|loading determine|dobj|recruitment determine|nsubj|binding binding|nmod|END_ENTITY	Phosphorylation and DNA binding of HJURP determine its centromeric recruitment and function in CenH3 -LRB- CENP-A -RRB- loading .
25843710	0	CENP-A	35,41	HJURP	0,5	CENP-A	HJURP	1058	55355	Gene	Gene	CenH3|appos|START_ENTITY Involvement|nmod|CenH3 Involvement|compound|END_ENTITY	HJURP Involvement in De Novo CenH3 -LRB- CENP-A -RRB- and CENP-C Recruitment .
11129795	0	CENP-A	67,73	centromere_protein_A	45,65	CENP-A	centromere protein A	1058	1058	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Centromere/kinetochore localization of human centromere_protein_A -LRB- CENP-A -RRB- exogenously expressed as a fusion to green fluorescent protein .
26586808	0	CENP-A/CID	59,69	Hat1	47,51	CENP-A/CID	Hat1	36495(Tax:7227)	43928(Tax:7227)	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila_melanogaster .
21911481	0	CENP-C	0,6	M18BP1	16,22	CENP-C	M18BP1	1060	55320	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly .
11925107	0	CENP-C	95,101	centromere_protein_C	72,92	CENP-C	centromere protein C	1060	1060	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Mutational analysis of the central centromere targeting domain of human centromere_protein_C , -LRB- CENP-C -RRB- .
26321640	0	CENP-E	34,40	CTCF	0,4	CENP-E	CTCF	1062	10664	Gene	Gene	START_ENTITY|nsubj|Protein Protein|compound|END_ENTITY	CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites .
26372373	0	CENP-E	54,60	Centromere-Associated_Protein-E	21,52	CENP-E	Centromere-Associated Protein-E	1062	1062	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Synthetic Studies on Centromere-Associated_Protein-E -LRB- CENP-E -RRB- Inhibitors : 2 .
23816042	0	CENP-E	54,60	centromere-associated_protein-E	21,52	CENP-E	centromere-associated protein-E	1062	1062	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthetic studies of centromere-associated_protein-E -LRB- CENP-E -RRB- inhibitors : 1 .
19232519	0	CENP-H	46,52	TRIM36	0,6	CENP-H	TRIM36	64946	55521	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression .
21056971	0	CENP-U	0,6	Hec1	23,27	CENP-U	Hec1	79682	10403	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	CENP-U cooperates with Hec1 to orchestrate kinetochore-microtubule attachment .
19410544	0	CENP-a	32,38	HJURP	66,71	CENP-a	HJURP	1058	55355	Gene	Gene	nucleosomes|amod|START_ENTITY assembly|nmod|nucleosomes mediated|nsubjpass|assembly mediated|nmod|END_ENTITY	Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP .
20140237	0	CENPC	37,42	centromere_protein_C	15,35	CENPC	centromere protein C	1060	1060	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	DNA binding of centromere_protein_C -LRB- CENPC -RRB- is stabilized by single-stranded RNA .
24586177	0	CEP-1	0,5	p53	34,37	CEP-1	p53	172616(Tax:6239)	7157	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	CEP-1 , the Caenorhabditis_elegans p53 homolog , mediates opposing longevity outcomes in mitochondrial electron transport chain mutants .
24586407	0	CEP-1	11,16	p53	17,20	CEP-1	p53	172616(Tax:6239)	7157	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|END_ENTITY	C. _ elegans CEP-1 / p53 and BEC-1 are involved in DNA repair .
23810536	0	CEP120	0,6	CPAP	33,37	CEP120	CPAP	153241	55835	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	CEP120 and SPICE1 cooperate with CPAP in centriole elongation .
23857771	0	CEP120	0,6	CPAP	22,26	CEP120	CPAP	153241	55835	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CEP120 interacts with CPAP and positively regulates centriole elongation .
23137637	0	CEP131	14,20	SP1	40,43	CEP131	SP1	22994	6667	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of CEP131 gene expression by SP1 .
23511974	0	CEP135	27,33	hSAS-6	43,49	CEP135	hSAS-6	9662	163786	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human microcephaly protein CEP135 binds to hSAS-6 and CPAP , and is required for centriole assembly .
16909394	0	CEP290	17,23	NPHP6	25,30	CEP290	NPHP6	80184	80184	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the CEP290 -LRB- NPHP6 -RRB- gene are a frequent cause of Leber_congenital_amaurosis .
17564974	0	CEP290	23,29	NPHP6	31,36	CEP290	NPHP6	80184	80184	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Pleiotropic effects of CEP290 -LRB- NPHP6 -RRB- mutations extend to Meckel_syndrome .
18772192	0	CEP290	0,6	PCM-1	57,62	CEP290	PCM-1	80184	5108	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium .
20176808	0	CEP55	21,26	TEX14	0,5	CEP55	TEX14	55165	56155	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TEX14 interacts with CEP55 to block cell abscission .
26300001	0	CEP72	22,27	BRCA1	61,66	CEP72	BRCA1	55722	672	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability .
20610395	0	CERK1	48,53	lysin_motif_receptor-like_kinase	4,36	CERK1	lysin motif receptor-like kinase	821717(Tax:3702)	816909(Tax:3702)	Gene	Gene	protein|advmod|START_ENTITY protein|nsubj|END_ENTITY	The lysin_motif_receptor-like_kinase -LRB- LysM-RLK -RRB- CERK1 is a major chitin-binding protein in Arabidopsis_thaliana and subject to chitin-induced phosphorylation .
26871237	0	CES1	78,82	carboxylesterase-1	58,76	CES1	carboxylesterase-1	1066	1066	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulatory effects of genomic translocations at the human carboxylesterase-1 -LRB- CES1 -RRB- gene locus .
19332024	0	CES1	34,38	carboxylesterase_1	14,32	CES1	carboxylesterase 1	1066	1066	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of carboxylesterase_1 -LRB- CES1 -RRB- in human adipose tissue .
22833659	0	CETP	74,78	CRBP2	67,72	CETP	CRBP2	1071	5948	Gene	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	Gender and single nucleotide polymorphisms in MTHFR , BHMT , SPTLC1 , CRBP2 , CETP , and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults .
26694435	0	CETP	109,113	Cholesterol_Ester_Transfer_Protein	73,107	CETP	Cholesterol Ester Transfer Protein	1071	1071	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol_Ester_Transfer_Protein -LRB- CETP -RRB- Gene and Dyslipidemia in National Minority Adults in the Far West Region of China .
18562803	0	CETP	50,54	LXRalpha	24,32	CETP	LXRalpha	1071	10062	Gene	Gene	promoter|compound|START_ENTITY signaling|nmod|promoter END_ENTITY|acl|signaling	FXRalpha down-regulates LXRalpha signaling at the CETP promoter via a common element .
20494359	0	CETP	25,29	LXRalpha	0,8	CETP	LXRalpha	1071	10062	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	LXRalpha regulates human CETP expression in vitro and in transgenic_mice .
26015437	0	CETP	4,8	PCSK9	33,38	CETP	PCSK9	1071	255738	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	New CETP Inhibitor K-312 Reduces PCSK9 Expression : A Potential Effect on LDL Cholesterol Metabolism .
11887180	0	CETP	94,98	cholesterol_ester_transfer_protein	58,92	CETP	cholesterol ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the intron 1 splice donor site of the cholesterol_ester_transfer_protein -LRB- CETP -RRB- gene as a cause of hyperalphalipoproteinemia .
17196207	0	CETP	47,51	cholesterol_ester_transfer_protein	11,45	CETP	cholesterol ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of cholesterol_ester_transfer_protein -LRB- CETP -RRB- gene on adiposity in response to long-term overfeeding .
19728844	0	CETP	58,62	cholesterol_ester_transfer_protein	22,56	CETP	cholesterol ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	TaqIB polymorphism in cholesterol_ester_transfer_protein -LRB- CETP -RRB- gene predicts future cardiovascular_death in patients experiencing an acute_coronary_syndrome .
22356288	0	CETP	200,204	cholesteryl_ester-transfer_protein	164,198	CETP	cholesteryl ester-transfer protein	1071	1071	Gene	Gene	discovery|appos|START_ENTITY discovery|nmod|END_ENTITY	On - and off-target pharmacology of torcetrapib : current understanding and implications for the structure activity relationships -LRB- SAR -RRB- , discovery and development of cholesteryl_ester-transfer_protein -LRB- CETP -RRB- inhibitors .
10831518	0	CETP	51,55	cholesteryl_ester_transfer_protein	15,49	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Linkage of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene to LDL particle size : use of a novel tetranucleotide repeat within the CETP promoter .
11029971	0	CETP	99,103	cholesteryl_ester_transfer_protein	63,97	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effect of postprandial lipaemia and Taq 1B polymorphism of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene on CETP mass , activity , associated lipoproteins and plasma lipids .
12070157	0	CETP	137,141	cholesteryl_ester_transfer_protein	92,126	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Apolipoprotein CI_deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl_ester_transfer_protein -LRB- CETP -RRB- in CETP transgenic/ApoCI-knocked out mice .
14998629	0	CETP	40,44	cholesteryl_ester_transfer_protein	4,38	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The cholesteryl_ester_transfer_protein -LRB- CETP -RRB- TaqIB polymorphism in the cholesterol and recurrent events study : no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome : a prospective analysis of the CETP TaqIB polymorphism on cardiovascular outcome and interaction with cholesterol-lowering therapy .
15228446	0	CETP	50,54	cholesteryl_ester_transfer_protein	14,48	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- in germinal centre B cells and their neoplastic counterparts .
16384616	0	CETP	62,66	cholesteryl_ester_transfer_protein	26,60	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	I405V polymorphism of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in young and very old people .
16829344	0	CETP	53,57	cholesteryl_ester_transfer_protein	17,51	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat .
19004846	0	CETP	121,125	cholesteryl_ester_transfer_protein	85,119	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Assessment of the CYP3A-mediated drug interaction potential of anacetrapib , a potent cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitor , in healthy volunteers .
19491422	0	CETP	58,62	cholesteryl_ester_transfer_protein	22,56	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Taq1B polymorphism of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in primary combined_hyperlipidaemia .
19843057	0	CETP	111,115	cholesteryl_ester_transfer_protein	75,109	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Single-dose pharmacokinetics and pharmacodynamics of anacetrapib , a potent cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitor , in healthy subjects .
20068209	0	CETP	84,88	cholesteryl_ester_transfer_protein	48,82	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a functional polymorphism in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene with memory decline and incidence of dementia .
22122993	0	CETP	55,59	cholesteryl_ester_transfer_protein	19,53	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in Japanese hyperalphalipoproteinemic subjects .
23658137	0	CETP	46,50	cholesteryl_ester_transfer_protein	10,44	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Future of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitors : a pharmacological perspective .
24176024	0	CETP	62,66	cholesteryl_ester_transfer_protein	26,60	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	TaqIB polymorphism in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men .
24659026	0	CETP	45,49	cholesteryl_ester_transfer_protein	9,43	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Elevated cholesteryl_ester_transfer_protein -LRB- CETP -RRB- activity , a major determinant of the atherogenic_dyslipidemia , and atherosclerotic_cardiovascular_disease in South Asians .
25366166	0	CETP	51,55	cholesteryl_ester_transfer_protein	15,49	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene polymorphism , high density lipoprotein cholesterol and risk of coronary_artery_disease : a meta-analysis using a Mendelian randomization approach .
2567644	0	CETP	65,69	cholesteryl_ester_transfer_protein	29,63	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	`` Variability gene '' effect of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- genes .
7910585	0	CETP	61,65	cholesteryl_ester_transfer_protein	25,59	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA polymorphisms of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in Italian and Greek migrants to Australia .
8447724	0	CETP	130,134	cholesteryl_ester_transfer_protein	94,128	LCAT	cholesteryl ester transfer protein	3931	1071	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Decrease of plasma large , light LDL -LRB- LDL1 -RRB- , HDL2 and HDL3 levels with concomitant increase of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- activity by probucol in type_II_hyperlipoproteinemia .
8830936	0	CETP	92,96	cholesteryl_ester_transfer_protein	56,90	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphic site in the 3 ' untranslated region of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene is associated with low CETP activity .
9543093	0	CETP	58,62	cholesteryl_ester_transfer_protein	22,56	CETP	cholesteryl ester transfer protein	1071	1071	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	R451Q mutation in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene is associated with high plasma CETP activity .
9714785	0	CETP	165,169	cholesteryl_ester_transfer_protein	35,69	CETP	cholesteryl ester transfer protein	1071	100758852	Gene	Gene	gene|compound|START_ENTITY transfected|nmod|gene line|acl:relcl|transfected Mechanism|nmod|line Mechanism|nmod|mRNA mRNA|amod|probucol probucol|nmod|END_ENTITY	Mechanism of action of probucol on cholesteryl_ester_transfer_protein -LRB- CETP -RRB- mRNA in a Chinese_hamster ovary cell line that had been stably transfected with a human CETP gene .
20520827	0	CF2	0,3	Actin_88F	14,23	CF2	Actin 88F	33692(Tax:7227)	41885(Tax:7227)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	CF2 represses Actin_88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila .
21163535	0	CFB	56,59	Complement_Factor_B	30,49	CFB	Complement Factor B	101115072	101115072	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the sheep Complement_Factor_B gene -LRB- CFB -RRB- .
20108004	0	CFB	50,53	complement_factor_B	24,43	CFB	complement factor B	629	629	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the complement_factor_B gene -LRB- CFB -RRB- and atypical_hemolytic_uremic_syndrome .
25277308	0	CFH	20,23	FPR1	0,4	CFH	FPR1	3075	2357	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FPR1 interacts with CFH , HTRA1 and smoking in exudative age-related_macular_degeneration and polypoidal_choroidal_vasculopathy .
18043728	0	CFH	39,42	complement_factor_H	18,37	CFH	complement factor H	3075	3075	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotypes in the complement_factor_H -LRB- CFH -RRB- gene : associations with drusen and advanced age-related macular_degeneration .
22302353	0	CFH	35,38	complement_factor_H	14,33	CFH	complement factor H	3075	3075	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of complement_factor_H -LRB- CFH -RRB- by multiple miRNAs in Alzheimer 's _ disease -LRB- AD -RRB- brain .
22509485	0	CFH	55,58	complement_factor_H	34,53	CFH	complement factor H	3075	3075	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Common micro RNAs -LRB- miRNAs -RRB- target complement_factor_H -LRB- CFH -RRB- regulation in Alzheimer 's _ disease -LRB- AD -RRB- and in age-related_macular_degeneration -LRB- AMD -RRB- .
23688582	0	CFI	40,43	STR	16,19	CFI	STR	3426	6779	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	A hypervariable STR polymorphism in the CFI gene : southern origin of East Asian-specific group H alleles .
10524238	0	CFI	129,132	complement_factor_I	108,127	CFI	complement factor I	3426	3426	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An initiator element and a proximal cis-acting sequence are essential for transcriptional activation of the complement_factor_I -LRB- CFI -RRB- gene .
18825487	0	CFI	40,43	complement_factor_I	19,38	CFI	complement factor I	3426	3426	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Molecular basis of complement_factor_I -LRB- CFI -RRB- polymorphism : one of two polymorphic suballeles responsible for CFI A is Japanese-specific .
19693526	0	CFI	61,64	complement_factor_I	40,59	CFI	complement factor I	3426	3426	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A hypervariable STR polymorphism in the complement_factor_I -LRB- CFI -RRB- gene : Asian-specific alleles .
11422377	0	CFL2	47,51	cofilin	38,45	CFL2	cofilin	1073	1072	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human muscle type cofilin -LRB- CFL2 -RRB- in normal and regenerating muscle .
8833095	0	CFR	75,78	cysteine-rich_fibroblast_growth_factor_receptor	26,73	CFR	cysteine-rich fibroblast growth factor receptor	396492(Tax:9031)	396492(Tax:9031)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the chicken cysteine-rich_fibroblast_growth_factor_receptor -LRB- CFR -RRB- during embryogenesis and retina development .
11713645	0	CFTR	31,35	Arginine_vasopressin	0,20	CFTR	Arginine vasopressin	24255(Tax:10116)	24221(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Arginine_vasopressin regulates CFTR and ClC-2 mRNA expression in rat kidney cortex and medulla .
20535216	0	CFTR	0,4	CFTR	44,48	CFTR	CFTR	1080	1080	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	CFTR expression and activity from the human CFTR locus in BAC vectors , with regulatory regions , isolated by a single-step procedure .
20535216	0	CFTR	44,48	CFTR	0,4	CFTR	CFTR	1080	1080	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	CFTR expression and activity from the human CFTR locus in BAC vectors , with regulatory regions , isolated by a single-step procedure .
24378376	0	CFTR	21,25	Cftr	49,53	CFTR	Cftr	12638(Tax:10090)	12638(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Marked repression of CFTR mRNA in the transgenic Cftr -LRB- tm1kth -RRB- mouse model .
25062999	0	CFTR	61,65	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	0,51	CFTR	Cystic Fibrosis Transmembrane Conductance Regulator	1080	1080	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Cystic_Fibrosis_Transmembrane_Conductance_Regulator Protein -LRB- CFTR -RRB- Expression in the Developing Human Brain : Comparative Immunohistochemical Study between Patients with Normal and Mutated CFTR .
26079370	0	CFTR	101,105	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	48,99	CFTR	Cystic Fibrosis Transmembrane Conductance Regulator	1080	1080	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Sphingosine-1-Phosphate Is a Novel Regulator of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Activity .
26087176	0	CFTR	121,125	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	68,119	CFTR	Cystic Fibrosis Transmembrane Conductance Regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prevalence of meconium ileus marks the severity of mutations of the Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- gene .
26208274	0	CFTR	69,73	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	16,67	CFTR	Cystic Fibrosis Transmembrane Conductance Regulator	1080	1080	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Distribution of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Mutations in a Cohort of Patients Residing in Palestine .
26208274	0	CFTR	69,73	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	16,67	CFTR	Cystic Fibrosis Transmembrane Conductance Regulator	1080	1080	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Distribution of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Mutations in a Cohort of Patients Residing in Palestine .
26694899	0	CFTR	66,70	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	13,64	CFTR	Cystic Fibrosis Transmembrane Conductance Regulator	1080	1080	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Mutations of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Gene Cause a Monocyte-selective Adhesion_Deficiency .
20530751	0	CFTR	53,57	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	CFTR	Cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- expression in human platelets : impact on mediators and mechanisms of the inflammatory response .
10898717	0	CFTR	0,4	DRA	31,34	CFTR	DRA	1080	1811	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	CFTR induces the expression of DRA along with Cl -LRB- - -RRB- / HCO -LRB- 3 -RRB- -LRB- - -RRB- exchange activity in tracheal epithelial cells .
14656222	0	CFTR	55,59	HNF1alpha	0,9	CFTR	HNF1alpha	12638(Tax:10090)	21405(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression involved|nmod|regulation involved|nsubjpass|END_ENTITY	HNF1alpha is involved in tissue-specific regulation of CFTR gene expression .
23555857	0	CFTR	72,76	Insulin-like_growth_factor_1	0,28	CFTR	Insulin-like growth factor 1	1080	3479	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- enhances the protein expression of CFTR .
7526699	0	CFTR	31,35	Interferon-gamma	0,16	CFTR	Interferon-gamma	1080	3458	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Interferon-gamma downregulates CFTR gene expression in epithelial cells .
17553491	0	CFTR	31,35	Interleukin-13	0,14	CFTR	Interleukin-13	1080	3596	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation .
10657593	0	CFTR	28,32	Interleukin-1beta	0,17	CFTR	Interleukin-1beta	1080	3553	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-1beta regulates CFTR expression in human intestinal T84 cells .
8654717	0	CFTR	62,66	Mucin	0,5	CFTR	Mucin	1080	100508689	Gene	Gene	protein|appos|START_ENTITY mediated|nmod|protein mediated|nsubj|secretion secretion|compound|END_ENTITY	Mucin secretion mediated by the cystic fibrosis gene protein , CFTR .
22510086	0	CFTR	26,30	Myosin_Ia	0,9	CFTR	Myosin Ia	12638(Tax:10090)	432516(Tax:10090)	Gene	Gene	trafficking|amod|START_ENTITY required|nmod|trafficking required|nsubjpass|END_ENTITY	Myosin_Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine .
20309604	0	CFTR	88,92	NF-E2-related_factor_2	0,22	CFTR	NF-E2-related factor 2	1080	4780	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	NF-E2-related_factor_2 , a key inducer of antioxidant defenses , negatively regulates the CFTR transcription .
19247502	0	CFTR	0,4	NFkappaB	32,40	CFTR	NFkappaB	1080	4790	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	CFTR is a negative regulator of NFkappaB mediated innate immune response .
16824484	0	CFTR	53,57	NHE3	0,4	CFTR	NHE3	1080	6550	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions .
24595473	0	CFTR	49,53	NHERF1	93,99	CFTR	NHERF1	12638(Tax:10090)	26941(Tax:10090)	Gene	Gene	START_ENTITY|nmod|modification modification|nmod|END_ENTITY	Pseudomonas_aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1 .
17409124	0	CFTR	59,63	RACK1	29,34	CFTR	RACK1	1080	10399	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the scaffold protein RACK1 in apical expression of CFTR .
10069998	0	CFTR	67,71	RANTES	75,81	CFTR	RANTES	1080	6352	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Chemokine expression in CF epithelia : implications for the role of CFTR in RANTES expression .
12509457	0	CFTR	16,20	RANTES	31,37	CFTR	RANTES	1080	6352	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif .
20658517	0	CFTR	19,23	SLC26A9	0,7	CFTR	SLC26A9	1080	115019	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	SLC26A9 stimulates CFTR expression and function in human bronchial cell lines .
17053783	0	CFTR	18,22	Slc26a6	0,7	CFTR	Slc26a6	12638(Tax:10090)	171429(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3 - secretion : relevance to cystic_fibrosis .
15361357	0	CFTR	25,29	TGF-beta_1	0,10	CFTR	TGF-beta 1	1080	7040	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	TGF-beta_1 downregulates CFTR expression and function in nasal_polyps of non-CF patients .
15265695	0	CFTR	31,35	TGFbeta	0,7	CFTR	TGFbeta	1080	7040	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|compound|END_ENTITY	TGFbeta down-regulation of the CFTR : a means to limit epithelial chloride secretion .
10036238	0	CFTR	0,4	VIP	103,106	CFTR	VIP	24255(Tax:10116)	117064(Tax:10116)	Gene	Gene	insertion|amod|START_ENTITY villus|nsubj|insertion villus|ccomp|upregulated upregulated|nmod|END_ENTITY	CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo .
24788249	0	CFTR	14,18	VIP	0,3	CFTR	VIP	1080	7432	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1 - and PKC - dependent manner .
25107366	0	CFTR	0,4	ZO-1	20,24	CFTR	ZO-1	12638(Tax:10090)	21872(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway .
10417323	0	CFTR	120,124	cystic_fibrosis_transmembrane_conductance_regulator	62,113	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of DNase-I-hypersensitive sites at the 3 ' end of the cystic_fibrosis_transmembrane_conductance_regulator gene -LRB- CFTR -RRB- .
10645285	0	CFTR	71,75	cystic_fibrosis_transmembrane_conductance_regulator	18,69	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- mRNA in normal and pathological adult human epididymis .
1283566	0	CFTR	114,118	cystic_fibrosis_transmembrane_conductance_regulator	61,112	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of CA/GT microsatellite polymorphism in IVS8 of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene : a study of Italian CF families .
1284534	0	CFTR	103,107	cystic_fibrosis_transmembrane_conductance_regulator	50,101	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations and sequence variations detected in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene : a report from the Cystic_Fibrosis Genetic Analysis Consortium .
1284540	0	CFTR	115,119	cystic_fibrosis_transmembrane_conductance_regulator	62,113	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of an intron 12 splice donor mutation in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
12939655	0	CFTR	78,82	cystic_fibrosis_transmembrane_conductance_regulator	25,76	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation analysis of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene , the cationic_trypsinogen -LRB- PRSS1 -RRB- gene , and the serine_protease_inhibitor , _ Kazal_type_1 -LRB- SPINK1 -RRB- gene in patients with alcoholic_chronic_pancreatitis .
1370810	0	CFTR	115,119	cystic_fibrosis_transmembrane_conductance_regulator	62,113	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Dinucleotide -LRB- CA/GT -RRB- repeat polymorphism in intron 17B of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
1379670	0	CFTR	238,242	cystic_fibrosis_transmembrane_conductance_regulator	177,228	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Localised mutagenesis of the fts YEX operon : conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia_coli are similar to those found in the cystic_fibrosis_transmembrane_conductance_regulator protein -LRB- CFTR -RRB- of human patients .
1382222	0	CFTR	156,160	cystic_fibrosis_transmembrane_conductance_regulator	103,154	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fluorescence-based , multiplex allele-specific PCR -LRB- MASPCR -RRB- detection of the delta F508 deletion in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
14602047	0	CFTR	64,68	cystic_fibrosis_transmembrane_conductance_regulator	70,121	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR -LRB- cystic_fibrosis_transmembrane_conductance_regulator -RRB- domain .
15286085	0	CFTR	73,77	cystic_fibrosis_transmembrane_conductance_regulator	20,71	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Novel regulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- channel gating by external chloride .
15357566	0	CFTR	93,97	cystic_fibrosis_transmembrane_conductance_regulator	40,91	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel missense mutation A1081P in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene identified in a Laotian patient with congenital_bilateral_absence_of_the_vas_deferens .
16246030	0	CFTR	144,148	cystic_fibrosis_transmembrane_conductance_regulator	91,142	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Crystallographic and single-particle analyses of native - and nucleotide-bound forms of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- protein .
16481627	0	CFTR	67,71	cystic_fibrosis_transmembrane_conductance_regulator	14,65	CFTR	cystic fibrosis transmembrane conductance regulator	12638(Tax:10090)	12638(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Assessment of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- activity in CFTR-null mice after bone marrow transplantation .
18687795	0	CFTR	133,137	cystic_fibrosis_transmembrane_conductance_regulator	80,131	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Validation of high-resolution DNA melting analysis for mutation scanning of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
19759008	0	CFTR	172,176	cystic_fibrosis_transmembrane_conductance_regulator	119,170	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of a disease-associated mutation affecting a putative splicing regulatory element in intron 6b of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
20483217	0	CFTR	85,89	cystic_fibrosis_transmembrane_conductance_regulator	32,83	CFTR	cystic fibrosis transmembrane conductance regulator	105927055	105927055	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and regulation of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene in killifish : A comparative genomics approach .
20974851	0	CFTR	67,71	cystic_fibrosis_transmembrane_conductance_regulator	14,65	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Modulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- activity and genistein binding by cytosolic pH. Potentiators are molecules that increase the activity of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- .
22131388	0	CFTR	151,155	cystic_fibrosis_transmembrane_conductance_regulator	90,141	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The decline of fertility in male uremic patients is correlated with low expression of the cystic_fibrosis_transmembrane_conductance_regulator protein -LRB- CFTR -RRB- in human sperm .
22186622	0	CFTR	105,109	cystic_fibrosis_transmembrane_conductance_regulator	52,103	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Novel action of the chalcone isoliquiritigenin as a cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- inhibitor : potential therapy for cholera and polycystic_kidney_disease .
22366595	0	CFTR	71,75	cystic_fibrosis_transmembrane_conductance_regulator	18,69	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- is associated with human cervical cancer_malignancy , progression and prognosis .
24782114	0	CFTR	129,133	cystic_fibrosis_transmembrane_conductance_regulator	76,127	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A balance between activating and repressive histone modifications regulates cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- expression in vivo .
25090262	0	CFTR	73,77	cystic_fibrosis_transmembrane_conductance_regulator	20,71	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Predictive value of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- in the diagnosis of gastric_cancer .
7540587	0	CFTR	118,122	cystic_fibrosis_transmembrane_conductance_regulator	65,116	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Three novel sequence variations in the 5 ' upstream region of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene : two polymorphisms and one putative molecular defect .
8163293	0	CFTR	100,104	cystic_fibrosis_transmembrane_conductance_regulator	47,98	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new missense mutation G126D in exon 4 of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
8428507	0	CFTR	103,107	cystic_fibrosis_transmembrane_conductance_regulator	50,101	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fluorescence in situ hybridization mapping of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene to 7q31 .3 .
8629807	0	CFTR	165,169	cystic_fibrosis_transmembrane_conductance_regulator	112,163	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Diagnostic usefulness of the polymorphism of the GT dinucleotide and the polythymidine tract in intron 8 of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
9346929	0	CFTR	95,99	cystic_fibrosis_transmembrane_conductance_regulator	101,152	CFTR	cystic fibrosis transmembrane conductance regulator	1080	1080	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	ATP depletion induces a loss of respiratory epithelium functional integrity and down-regulates CFTR -LRB- cystic_fibrosis_transmembrane_conductance_regulator -RRB- expression .
1281385	0	CFTR	66,70	cystic_fibrosis_transmembrane_regulator	25,64	CFTR	cystic fibrosis transmembrane regulator	1080	1080	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Ethnic heterogeneity and cystic_fibrosis_transmembrane_regulator -LRB- CFTR -RRB- mutation frequencies in Chicago-area CF families .
9482579	0	CFTR	82,86	cystic_fibrosis_transmembrane_regulator	41,80	CFTR	cystic fibrosis transmembrane regulator	1080	1080	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of five novel mutations of the cystic_fibrosis_transmembrane_regulator -LRB- CFTR -RRB- gene in Pakistani patients with cystic_fibrosis : Y569D , Q98X , 296 +12 -LRB- T > C -RRB- , 1161delC and 621 +2 -LRB- T > C -RRB- .
11114294	0	CFTR	37,41	interleukin-1beta	77,94	CFTR	interleukin-1beta	1080	3553	Gene	Gene	expression|amod|START_ENTITY up-regulation|nmod|expression mediates|dobj|up-regulation mediates|advcl|END_ENTITY	NF-kappa_B mediates up-regulation of CFTR gene expression in Calu-3 cells by interleukin-1beta .
11278608	0	CFTR	103,107	interleukin-1beta	112,129	CFTR	interleukin-1beta	1080	3553	Gene	Gene	cystic_fibrosis_transmembrane_conductance_regulator|appos|START_ENTITY regulation|nmod|cystic_fibrosis_transmembrane_conductance_regulator involved|nmod|regulation involved|advcl|END_ENTITY	NF-kappaB activation is involved in regulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- by interleukin-1beta .
10089213	0	CFTR	0,4	mucin	75,80	CFTR	mucin	1080	100508689	Gene	Gene	expression|amod|START_ENTITY influence|nsubj|expression influence|dobj|glycosylation glycosylation|nmod|END_ENTITY	CFTR expression does not influence glycosylation of an epitope-tagged MUC1 mucin in colon_carcinoma cell lines .
7524485	0	CFTR	39,43	mucin	13,18	CFTR	mucin	1080	100508689	Gene	Gene	expression|amod|START_ENTITY linked|nmod|expression linked|nsubj|secretion secretion|compound|END_ENTITY	Constitutive mucin secretion linked to CFTR expression .
9831904	0	CFTR	55,59	mucin	95,100	CFTR	mucin	24255(Tax:10116)	65202(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Actions of adenosine A1 and A2 receptor antagonists on CFTR antibody-inhibited beta-adrenergic mucin secretion response .
22797075	0	CFTR	0,4	urokinase_plasminogen_activator	61,92	CFTR	urokinase plasminogen activator	1080	5328	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	CFTR suppresses tumor progression through miR-193b targeting urokinase_plasminogen_activator -LRB- uPA -RRB- in prostate_cancer .
23088985	0	CG0070	34,40	GM-CSF	44,50	CG0070	GM-CSF	3344628(Tax:196627)	1437	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A first in human phase 1 study of CG0070 , a GM-CSF expressing oncolytic adenovirus , for the treatment of nonmuscle invasive bladder_cancer .
19947543	0	CG32500	96,103	CG32819	105,112	CG32500	CG32819	2768879(Tax:7227)	318227(Tax:7227)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Analysis of the structure and expression of the cluster of Drosophila_melanogaster genes DIP1 , CG32500 , CG32819 , and CG14476 in the flamenco gene region -RSB- .
19947543	0	CG32500	96,103	DIP1	90,94	CG32500	DIP1	2768879(Tax:7227)	43981(Tax:7227)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Analysis of the structure and expression of the cluster of Drosophila_melanogaster genes DIP1 , CG32500 , CG32819 , and CG14476 in the flamenco gene region -RSB- .
19947543	0	CG32819	105,112	CG32500	96,103	CG32819	CG32500	318227(Tax:7227)	2768879(Tax:7227)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Analysis of the structure and expression of the cluster of Drosophila_melanogaster genes DIP1 , CG32500 , CG32819 , and CG14476 in the flamenco gene region -RSB- .
19947543	0	CG32819	105,112	DIP1	90,94	CG32819	DIP1	318227(Tax:7227)	43981(Tax:7227)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Analysis of the structure and expression of the cluster of Drosophila_melanogaster genes DIP1 , CG32500 , CG32819 , and CG14476 in the flamenco gene region -RSB- .
23295489	0	CG5036	159,165	RGS	145,148	CG5036	RGS	37037(Tax:7227)	5308	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Crystallization and preliminary X-ray diffraction studies of Drosophila_melanogaster Gao-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036 .
23510993	0	CGB5	15,19	MTA3	0,4	CGB5	MTA3	93659	57504	Gene	Gene	genes|compound|START_ENTITY regulates|dobj|genes regulates|nsubj|END_ENTITY	MTA3 regulates CGB5 and Snail genes in trophoblast .
21832169	0	CGB6	125,129	CGB7	113,117	CGB6	CGB7	94027	94027	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Expression and production of human chorionic_gonadotropin _ -LRB- hCG -RRB- in the normal secretory endometrium : evidence of CGB7 and/or CGB6 beta hCG subunit gene expression .
21832169	0	CGB6	125,129	hCG	135,138	CGB6	hCG	94027	93659	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Expression and production of human chorionic_gonadotropin _ -LRB- hCG -RRB- in the normal secretory endometrium : evidence of CGB7 and/or CGB6 beta hCG subunit gene expression .
21832169	0	CGB7	113,117	CGB6	125,129	CGB7	CGB6	94027	94027	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Expression and production of human chorionic_gonadotropin _ -LRB- hCG -RRB- in the normal secretory endometrium : evidence of CGB7 and/or CGB6 beta hCG subunit gene expression .
21832169	0	CGB7	113,117	hCG	135,138	CGB7	hCG	94027	93659	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Expression and production of human chorionic_gonadotropin _ -LRB- hCG -RRB- in the normal secretory endometrium : evidence of CGB7 and/or CGB6 beta hCG subunit gene expression .
22032922	0	CGB7	107,111	p53	21,24	CGB7	p53	94027	7157	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene induces|dobj|expression induces|nsubj|END_ENTITY	The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin -LRB- hCG -RRB- CGB7 gene .
11498528	0	CGRP	0,4	CGRP	25,29	CGRP	CGRP	796	796	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	CGRP receptors mediating CGRP - , adrenomedullin - and amylin-induced relaxation in porcine coronary arteries .
11498528	0	CGRP	25,29	CGRP	0,4	CGRP	CGRP	796	796	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	CGRP receptors mediating CGRP - , adrenomedullin - and amylin-induced relaxation in porcine coronary arteries .
23376701	0	CGRP	22,26	CRF	62,65	CGRP	CRF	796	1392	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors .
25860809	0	CGRP	33,37	Calcitonin_Gene-Related_Peptide	0,31	CGRP	Calcitonin Gene-Related Peptide	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	Receptors|appos|START_ENTITY Receptors|amod|END_ENTITY	Calcitonin_Gene-Related_Peptide -LRB- CGRP -RRB- Receptors Are Important to Maintain Cerebrovascular Reactivity in Chronic Hypertension .
10209067	0	CGRP	33,37	Calcitonin_gene-related_peptide	0,31	CGRP	Calcitonin gene-related peptide	796	796	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- increases intracellular free Ca2 + concentrations but not cyclic_AMP formation in CGRP_receptor-positive osteosarcoma cells -LRB- OHS-4 -RRB- .
11035643	0	CGRP	33,37	Calcitonin_gene-related_peptide	0,31	CGRP	Calcitonin gene-related peptide	796	796	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- expression in the human neonatal paravertebral ganglia .
15237096	0	CGRP	33,37	Calcitonin_gene-related_peptide	0,31	CGRP	Calcitonin gene-related peptide	796	796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonists : blockers of neuronal transmission in migraine .
20433208	0	CGRP	33,37	Calcitonin_gene-related_peptide	0,31	CGRP	Calcitonin gene-related peptide	796	796	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists in the treatment of migraine .
2177866	0	CGRP	33,37	Calcitonin_gene-related_peptide	0,31	CGRP	Calcitonin gene-related peptide	796	796	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors are linked to cyclic_adenosine_monophosphate production in SK-N-MC human neuroblastoma cells .
8535845	0	CGRP	33,37	Calcitonin_gene-related_peptide	0,31	CGRP	Calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- content and CGRP receptor binding sites in discrete forebrain regions of alcohol-preferring vs. - nonpreferring rats , and high_alcohol-drinking vs. low alcohol-drinking rats .
23156733	0	CGRP	12,16	E-cadherin	24,34	CGRP	E-cadherin	796	999	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of CGRP on the E-cadherin expression in human bronchial epithelial cells -RSB- .
8404688	0	CGRP	79,83	IAPP	116,120	CGRP	IAPP	796	3375	Gene	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	Molecular identification of binding sites for calcitonin gene-related peptide -LRB- CGRP -RRB- and islet amyloid polypeptide -LRB- IAPP -RRB- in mammalian lung : species variation and binding of truncated CGRP and IAPP .
21179773	0	CGRP	12,16	MMP-9	32,37	CGRP	MMP-9	24241(Tax:10116)	81687(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Effects of CGRP on LPS-induced MMP-9 secretion by alveolar macrophages -RSB- .
24210136	0	CGRP	0,4	PACAP	25,30	CGRP	PACAP	796	116	Gene	Gene	START_ENTITY|parataxis|play play|nsubj|END_ENTITY	CGRP and migraine : could PACAP play a role too ?
25463029	0	CGRP	16,20	PACAP	37,42	CGRP	PACAP	24241(Tax:10116)	24166(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of CGRP , CGRP receptor , PACAP and glutamate in trigeminal_ganglion .
25463029	0	CGRP	22,26	PACAP	37,42	CGRP	PACAP	24241(Tax:10116)	24166(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY Localization|appos|receptor END_ENTITY|nsubj|Localization	Localization of CGRP , CGRP receptor , PACAP and glutamate in trigeminal_ganglion .
9178350	0	CGRP	120,124	PACAP	76,81	CGRP	PACAP	24241(Tax:10116)	24166(Tax:10116)	Gene	Gene	pituitary_adenylate_cyclase_activating_peptide|appos|START_ENTITY pituitary_adenylate_cyclase_activating_peptide|appos|END_ENTITY	Capsaicin-evoked release of pituitary_adenylate_cyclase_activating_peptide -LRB- PACAP -RRB- and calcitonin_gene-related_peptide -LRB- CGRP -RRB- from rat spinal cord in vivo .
11585594	0	CGRP	154,158	adrenomedullin	124,138	CGRP	adrenomedullin	24241(Tax:10116)	25026(Tax:10116)	Gene	Gene	addition|nmod|START_ENTITY END_ENTITY|nmod|addition	The calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonist CGRP -LRB- 8-37 -RRB- blocks vasodilatation in inflamed rat skin : involvement of adrenomedullin in addition to CGRP .
16873605	0	CGRP	81,85	alpha-Calcitonin_Gene-Related_Peptide	42,79	CGRP	alpha-Calcitonin Gene-Related Peptide	796	796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Pharmacological characterization of novel alpha-Calcitonin_Gene-Related_Peptide -LRB- CGRP -RRB- receptor peptide antagonists that are selective for human CGRP receptors .
12196117	0	CGRP	90,94	calcitonin-gene-related_peptide	57,88	CGRP	calcitonin-gene-related peptide	796	796	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Development and potential of non-peptide antagonists for calcitonin-gene-related_peptide -LRB- CGRP -RRB- receptors : evidence for CGRP receptor heterogeneity .
10880881	0	CGRP	62,66	calcitonin-gene_related_peptide	29,60	CGRP	calcitonin-gene related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of central calcitonin-gene_related_peptide -LRB- CGRP -RRB- on pancreatic secretion in conscious rats .
10425745	0	CGRP	45,49	calcitonin_gene-related_peptide	12,43	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of calcitonin_gene-related_peptide -LRB- CGRP -RRB- - containing nerve fibres in the rat spinal cord using light and electron microscopy .
10877837	0	CGRP	54,58	calcitonin_gene-related_peptide	21,52	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	A novel receptor for calcitonin_gene-related_peptide -LRB- CGRP -RRB- mediates secretion in the rat colon : implications for secretory function in colitis .
11324552	0	CGRP	47,51	calcitonin_gene-related_peptide	14,45	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- mRNA in rat lymphocytes .
11396788	0	CGRP	93,97	calcitonin_gene-related_peptide	60,91	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of vasoactive_intestinal_polypeptide _ -LRB- VIP -RRB- and calcitonin_gene-related_peptide -LRB- CGRP -RRB- expression in stellate ganglia of children with congenital cardiovascular_lesions .
11576394	0	CGRP	43,47	calcitonin_gene-related_peptide	10,41	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on motility and on the release of substance_P , neurokinin_A , somatostatin and gastrin in the isolated perfused porcine antrum .
11642727	0	CGRP	46,50	calcitonin_gene-related_peptide	13,44	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of calcitonin_gene-related_peptide -LRB- CGRP -RRB- by rat arterial endothelial cells .
11804624	0	CGRP	53,57	calcitonin_gene-related_peptide	20,51	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Characterization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors and their receptor-activity-modifying_proteins -LRB- RAMPs -RRB- in human brain microvascular and astroglial cells in culture .
11985877	0	CGRP	96,100	calcitonin_gene-related_peptide	63,94	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Reciprocal age-related changes in GAP-43 / B-50 , substance P and calcitonin_gene-related_peptide -LRB- CGRP -RRB- expression in rat primary sensory neurones and their terminals in the dorsal horn of the spinal cord and subintima of the knee synovium .
12220736	0	CGRP	41,45	calcitonin_gene-related_peptide	8,39	CGRP	calcitonin gene-related peptide	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in chronic hypoxia-induced pulmonary_hypertension in the mouse .
12855330	0	CGRP	45,49	calcitonin_gene-related_peptide	12,43	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin .
1310134	0	CGRP	90,94	calcitonin_gene-related_peptide	57,88	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Pharmacological evidence for the involvement of multiple calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in the antisecretory and antiulcer effect of CGRP in rat stomach .
15085045	0	CGRP	47,51	calcitonin_gene-related_peptide	14,45	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in irreversible acute pulpitis .
15228501	0	CGRP	48,52	calcitonin_gene-related_peptide	15,46	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Effects of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats .
15623815	0	CGRP	56,60	calcitonin_gene-related_peptide	23,54	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Evidence for decreased calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies .
16438955	0	CGRP	45,49	calcitonin_gene-related_peptide	12,43	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in ischemic preconditioning in isolated rat hearts .
17027165	0	CGRP	81,85	calcitonin_gene-related_peptide	48,79	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Muscle_inflammation induces a rapid increase in calcitonin_gene-related_peptide -LRB- CGRP -RRB- mRNA that temporally relates to CGRP immunoreactivity and nociceptive_behavior .
18186028	0	CGRP	125,129	calcitonin_gene-related_peptide	92,123	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Calcitonin_receptor-like_receptor -LRB- CLR -RRB- , receptor_activity-modifying_protein_1 -LRB- RAMP1 -RRB- , and calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in the rat trigeminovascular system : differences between peripheral and central CGRP receptor distribution .
1873010	0	CGRP	56,60	calcitonin_gene-related_peptide	23,54	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Normal serum levels of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in mild to moderate essential_hypertension .
18835571	0	CGRP	43,47	calcitonin_gene-related_peptide	10,41	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on avian appetite-related processes .
1889317	0	CGRP	45,49	calcitonin_gene-related_peptide	12,43	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	-LSB- Changes of calcitonin_gene-related_peptide -LRB- CGRP -RRB- concentrations in CSF in patients with cerebrovascular_disorders -RSB- .
19053766	0	CGRP	122,126	calcitonin_gene-related_peptide	89,120	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Identification of potent , selective , and metabolically stable peptide antagonists to the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor .
1980300	0	CGRP	54,58	calcitonin_gene-related_peptide	21,52	CGRP	calcitonin gene-related peptide	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Inhibitory action of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in the mouse colon .
20855369	0	CGRP	47,51	calcitonin_gene-related_peptide	14,45	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Effect of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist telcagepant in human cranial arteries .
2359517	0	CGRP	44,48	calcitonin_gene-related_peptide	11,42	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of calcitonin_gene-related_peptide -LRB- CGRP -RRB- from capsaicin-sensitive vasodilator nerves in the rat mesenteric artery .
23674158	0	CGRP	47,51	calcitonin_gene-related_peptide	14,45	CGRP	calcitonin gene-related peptide	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of calcitonin_gene-related_peptide -LRB- CGRP -RRB- has the potential to extend first-phase insulin secretion .
23868210	0	CGRP	60,64	calcitonin_gene-related_peptide	27,58	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Peptide antagonists of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor with improved pharmacokinetics and pharmacodynamics .
2390722	0	CGRP	44,48	calcitonin_gene-related_peptide	11,42	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in calcitonin_gene-related_peptide -LRB- CGRP -RRB- - containing vasodilator nerve activity in hypertension .
2394085	0	CGRP	47,51	calcitonin_gene-related_peptide	14,45	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on human forearm blood flow .
23993336	0	CGRP	69,73	calcitonin_gene-related_peptide	36,67	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Preparation of imidazoles as potent calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonists .
2536276	0	CGRP	83,87	calcitonin_gene-related_peptide	50,81	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and characterisation of immunoreactive calcitonin_gene-related_peptide -LRB- CGRP -RRB- from a CGRP receptor-positive cloned osteosarcoma cell line -LRB- UMR 106.01 -RRB- .
2557987	0	CGRP	58,62	calcitonin_gene-related_peptide	25,56	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated serum levels of calcitonin_gene-related_peptide -LRB- CGRP -RRB- but no evidence for CGRP gene expression in non-small cell lung_carcinomas .
25670002	0	CGRP	84,88	calcitonin_gene-related_peptide	51,82	CGRP	calcitonin gene-related peptide	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Microglial content-dependent inhibitory effects of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on murine retroviral_infection of glial cells .
2579983	0	CGRP	60,64	calcitonin_gene-related_peptide	27,58	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Distribution and origin of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in the sensory innervation of the mammalian eye .
2613943	0	CGRP	48,52	calcitonin_gene-related_peptide	15,46	CGRP	calcitonin gene-related peptide	396256(Tax:9031)	396256(Tax:9031)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Development of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in relationship to the formation of neuromuscular junctions in Xenopus myotomal muscle .
26231160	0	CGRP	53,57	calcitonin_gene-related_peptide	20,51	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
26231160	0	CGRP	53,57	calcitonin_gene-related_peptide	20,51	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
26832218	0	CGRP	54,58	calcitonin_gene-related_peptide	21,52	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and SAR of calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonists containing substituted aryl-piperazines and piperidines .
27021026	0	CGRP	60,64	calcitonin_gene-related_peptide	27,58	CGRP	calcitonin gene-related peptide	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Expression and function of calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in trigeminal ganglia of R192Q Cacna1a knock-in mice .
2786708	0	CGRP	61,65	calcitonin_gene-related_peptide	28,59	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	-LSB- Radioimmunoassay of plasma calcitonin_gene-related_peptide -LRB- CGRP -RRB- levels in patients with endocrine_tumor -RSB- .
2843180	0	CGRP	77,81	calcitonin_gene-related_peptide	44,75	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Positive inotropic effects and receptors of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in porcine ventricular muscles .
2854248	0	CGRP	66,70	calcitonin_gene-related_peptide	33,64	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Autoradiographic localization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- binding sites in human and guinea_pig lung .
2886386	0	CGRP	44,48	calcitonin_gene-related_peptide	11,42	CGRP	calcitonin gene-related peptide	100124407(Tax:9823)	100124407(Tax:9823)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on islet hormone secretion in the pig .
3118566	0	CGRP	60,64	calcitonin_gene-related_peptide	27,58	CGRP	calcitonin gene-related peptide	796	24241(Tax:10116)	Gene	Gene	Studies|appos|START_ENTITY Studies|nmod|localization localization|nmod|END_ENTITY	Studies on localization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in the thyroid-parathyroid complex .
3265774	0	CGRP	49,53	calcitonin_gene-related_peptide	16,47	CGRP	calcitonin gene-related peptide	796	796	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- at a neuronal nicotinic synapse .
3282604	0	CGRP	70,74	calcitonin_gene-related_peptide	37,68	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immuno-electron microscopic study of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in axis cylinders of the vagus nerve .
3498561	0	CGRP	65,69	calcitonin_gene-related_peptide	32,63	CGRP	calcitonin gene-related peptide	796	24241(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Basal and stimulated release of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in patients with medullary_thyroid_carcinoma .
7507998	0	CGRP	81,85	calcitonin_gene-related_peptide	48,79	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Pharmacological characterization of presynaptic calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors on CGRP-containing vasodilator nerves in rat mesenteric resistance vessels .
7967233	0	CGRP	69,73	calcitonin_gene-related_peptide	36,67	CGRP	calcitonin gene-related peptide	396256(Tax:9031)	396256(Tax:9031)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Structure-activity study of chicken calcitonin_gene-related_peptide -LRB- CGRP -RRB- on vasorelaxation in rat mesenteric resistance vessels .
8105830	0	CGRP	54,58	calcitonin_gene-related_peptide	21,52	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Early changes in the calcitonin_gene-related_peptide -LRB- CGRP -RRB- content of pulmonary endocrine cells concomitant with vascular remodeling in the hypoxic rat .
8182554	0	CGRP	64,68	calcitonin_gene-related_peptide	31,62	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Binding profile of a selective calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist ligand , -LSB- 125I-Tyr -RSB- hCGRP8-37 , in rat brain and peripheral tissues .
8278635	0	CGRP	55,59	calcitonin_gene-related_peptide	22,53	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	12310(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Characterization of a calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor on mouse bone marrow cells .
8698903	0	CGRP	66,70	calcitonin_gene-related_peptide	33,64	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Sexually dimorphic expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity by rat mediobasal hypothalamic neurons .
8745063	0	CGRP	63,67	calcitonin_gene-related_peptide	30,61	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in a rat medullary thyroid_carcinoma cell line .
8750870	0	CGRP	66,70	calcitonin_gene-related_peptide	33,64	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Sexually dimorphic expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- mRNA in rat medial_preoptic_nucleus .
9272685	0	CGRP	78,82	calcitonin_gene-related_peptide	45,76	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Evidence for a physiological role of central calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in the control of food intake in rats .
9469578	0	CGRP	153,157	calcitonin_gene-related_peptide	120,151	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- protects dorsal root ganglion neurons from death and induces calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in vitro .
9579744	0	CGRP	53,57	calcitonin_gene-related_peptide	20,51	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Characterization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in intramural coronary arteries from male and female Sprague_Dawley_rats .
9606032	0	CGRP	56,60	calcitonin_gene-related_peptide	23,54	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Relaxant effect of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- on the nonpregnant and pregnant rat uterus .
9660718	0	CGRP	76,80	calcitonin_gene-related_peptide	43,74	CGRP	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Morphological evidence for the location of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in rat lymphocytes .
20143189	0	CGRP	95,99	calcitonin_gene_related_peptide	62,93	CGRP	calcitonin gene related peptide	796	796	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Breast density , scintimammographic -LRB- 99m -RRB- Tc -LRB- V -RRB- DMSA uptake , and calcitonin_gene_related_peptide -LRB- CGRP -RRB- expression in mixed invasive ductal associated with extensive in __ situ_ductal_carcinoma -LRB- IDC + DCIS -RRB- and pure_invasive_ductal_carcinoma -LRB- IDC -RRB- : correlation with estrogen_receptor -LRB- ER -RRB- status , proliferation index Ki-67 , and histological grade .
8846401	0	CGRP	44,48	calcitonin_gene_related_peptide	11,42	CGRP	calcitonin gene related peptide	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for calcitonin_gene_related_peptide -LRB- CGRP -RRB- in the regulation of early B lymphocyte differentiation .
8846438	0	CGRP	97,101	calcitonin_gene_related_peptide	64,95	CGRP	calcitonin gene related peptide	796	796	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Multiple affinity and guanine_nucleotide sensitive forms of the calcitonin_gene_related_peptide -LRB- CGRP -RRB- receptor .
12086988	0	CGRP	127,131	calcitonin_receptor-like_receptor	32,65	CGRP	calcitonin receptor-like receptor	24241(Tax:10116)	25029(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Comparison of the expression of calcitonin_receptor-like_receptor -LRB- CRLR -RRB- and receptor activity modifying proteins -LRB- RAMPs -RRB- with CGRP and adrenomedullin binding in cell lines .
19457095	0	CGRP	0,4	iNOS	20,24	CGRP	iNOS	24241(Tax:10116)	24599(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways .
16611736	0	CGRP	0,4	osteoprotegerin	14,29	CGRP	osteoprotegerin	796	4982	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP/PKA-dependent pathway .
21933441	0	CGRP	65,69	p38	29,32	CGRP	p38	24241(Tax:10116)	81649(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	On the possible role of ERK , p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats .
21566843	0	CH3	74,77	CH4	61,64	CH3	CH4	40308(Tax:7227)	35759(Tax:7227)	Gene	Gene	reaction|compound|START_ENTITY reaction|compound|END_ENTITY	Quasi-classical trajectory study of the dynamics of the Cl + CH4 > HCl + CH3 reaction .
21566843	0	CH4	61,64	CH3	74,77	CH4	CH3	35759(Tax:7227)	40308(Tax:7227)	Gene	Gene	reaction|compound|START_ENTITY reaction|compound|END_ENTITY	Quasi-classical trajectory study of the dynamics of the Cl + CH4 > HCl + CH3 reaction .
15327999	0	CHASM	45,50	smoothelin	74,84	CHASM	smoothelin	219537	6525	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Modulation of smooth muscle contractility by CHASM , a novel member of the smoothelin family of proteins .
14682613	0	CHB2	0,4	SWI3	22,26	CHB2	SWI3	817927(Tax:3702)	853264(Tax:4932)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	CHB2 , a member of the SWI3 gene family , is a global regulator in Arabidopsis .
15133132	0	CHC22	17,22	sorting_nexin_5	87,102	CHC22	sorting nexin 5	8218	27131	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Clathrin isoform CHC22 , a component of neuromuscular and myotendinous junctions , binds sorting_nexin_5 and has increased expression during myogenesis and muscle regeneration .
12890497	0	CHD1	0,4	NCoR	21,25	CHD1	NCoR	1105	9611	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	CHD1 associates with NCoR and histone_deacetylase as well as with RNA splicing proteins .
10199952	0	CHD1	0,4	SSRP1	20,25	CHD1	SSRP1	1105	6749	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin .
10570159	0	CHD3	12,16	PICKLE	0,6	CHD3	PICKLE	817055(Tax:3702)	817055(Tax:3702)	Gene	Gene	factor|compound|START_ENTITY factor|nsubj|END_ENTITY	PICKLE is a CHD3 chromatin-remodeling factor that regulates the transition from embryonic to vegetative development in Arabidopsis .
23071088	0	CHD4	29,33	MBD2	0,4	CHD4	MBD2	1108	8932	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2 / NuRD complexes .
24440720	0	CHD4	42,46	ZFHX4	0,5	CHD4	ZFHX4	1108	79776	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state .
22235338	0	CHD5	114,118	MicroRNA-211	0,12	CHD5	MicroRNA-211	26038	406993	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|expression expression|amod|END_ENTITY	MicroRNA-211 expression promotes colorectal_cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5 .
25247294	0	CHD5	32,36	WEE1	71,75	CHD5	WEE1	26038	7465	Gene	Gene	Repressor|nsubj|START_ENTITY Repressor|nmod|END_ENTITY	The Chromatin Remodeling Factor CHD5 Is a Transcriptional Repressor of WEE1 .
20453063	0	CHD7	20,24	CHD8	0,4	CHD7	CHD8	55636	57680	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CHD8 interacts with CHD7 , a protein which is mutated in CHARGE_syndrome .
20453063	0	CHD8	0,4	CHD7	20,24	CHD8	CHD7	57680	55636	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CHD8 interacts with CHD7 , a protein which is mutated in CHARGE_syndrome .
19372713	0	CHEK2	82,87	BRCA1	68,73	CHEK2	BRCA1	11200	672	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Age at onset of bilateral_breast_cancer , the presence of hereditary BRCA1 , BRCA2 , CHEK2 gene mutations and positive family history of cancer .
21356067	0	CHEK2	28,33	BRCA1	14,19	CHEK2	BRCA1	11200	672	Gene	Gene	RAD50|appos|START_ENTITY RAD50|compound|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
22420423	0	CHEK2	48,53	TP53	55,59	CHEK2	TP53	11200	7157	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Low expression levels of ATM may substitute for CHEK2 / TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast_cancer .
16951149	0	CHES1	81,86	Multiple_endocrine_neoplasia_type_1	0,35	CHES1	Multiple endocrine neoplasia type 1	1112	4221	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Multiple_endocrine_neoplasia_type_1 interacts with forkhead transcription factor CHES1 in DNA damage response .
8034306	0	CHH	66,69	cartilage-hair_hypoplasia	39,64	CHH	cartilage-hair hypoplasia	6023	6023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High-resolution genetic mapping of the cartilage-hair_hypoplasia -LRB- CHH -RRB- gene in Amish and Finnish families .
26528713	0	CHI3L1	12,18	Chitinase-3-Like-1	20,38	CHI3L1	Chitinase-3-Like-1	12654(Tax:10090)	12654(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of CHI3L1 -LRB- Chitinase-3-Like-1 -RRB- in the Pathogenesis of Infections in Burns in a Mouse Model .
18281018	0	CHI3L1	20,26	Chitinase-3-like_1	0,18	CHI3L1	Chitinase-3-like 1	1116	1116	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chitinase-3-like_1 -LRB- CHI3L1 -RRB- gene and schizophrenia : genetic association and a potential functional mechanism .
18403759	0	CHI3L1	23,29	YKL-40	39,45	CHI3L1	YKL-40	1116	1116	Gene	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Effect of variation in CHI3L1 on serum YKL-40 level , risk of asthma , and lung function .
24958781	0	CHI3L1	115,121	chitinase_3-like_1	90,108	CHI3L1	chitinase 3-like 1	1116	1116	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40 , variation in the chitinase_3-like_1 gene -LRB- CHI3L1 -RRB- , and incident cardiovascular events .
23246967	0	CHIP	47,51	Androgen_receptor	0,17	CHIP	Androgen receptor	358	367	Gene	Gene	START_ENTITY|nsubj|degradation degradation|compound|END_ENTITY	Androgen_receptor degradation by the E3 ligase CHIP modulates mitotic_arrest in prostate_cancer cells .
22824801	0	CHIP	91,95	Hsp70	30,35	CHIP	Hsp70	358	3308	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances .
20924358	0	CHIP	83,87	SENP3	55,60	CHIP	SENP3	358	26168	Gene	Gene	interactions|nmod|START_ENTITY END_ENTITY|nmod|interactions	Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90 .
25773675	0	CHIP	0,4	amyloid_precursor_protein	16,41	CHIP	amyloid precursor protein	358	351	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	CHIP stabilizes amyloid_precursor_protein via proteasomal degradation and p53-mediated trans-repression of b-secretase .
15107424	0	CHIP	117,121	androgen_receptor	3,20	CHIP	androgen receptor	358	367	Gene	Gene	COOH_terminus_of_the_Hsp70-interacting_protein|appos|START_ENTITY conserved|nmod|COOH_terminus_of_the_Hsp70-interacting_protein conserved|nsubj|NH2-terminal NH2-terminal|compound|END_ENTITY	An androgen_receptor NH2-terminal conserved motif interacts with the COOH_terminus_of_the_Hsp70-interacting_protein -LRB- CHIP -RRB- .
16725394	0	CHIP	24,28	androgen_receptor	39,56	CHIP	androgen receptor	358	367	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The E3 ubiquitin ligase CHIP binds the androgen_receptor in a phosphorylation-dependent manner .
22543587	0	CHIP	21,25	c-Myc	36,41	CHIP	c-Myc	358	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity .
16037132	0	CHIP	0,4	estrogen_receptor-alpha	109,132	CHIP	estrogen receptor-alpha	358	2099	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	CHIP -LRB- carboxyl_terminus_of_Hsc70-interacting_protein -RRB- promotes basal and geldanamycin-induced degradation of estrogen_receptor-alpha .
19892702	0	CHIP	13,17	malin	45,50	CHIP	malin	358	378884	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Co-chaperone CHIP stabilizes aggregate-prone malin , a ubiquitin ligase mutated in Lafora_disease .
15329911	0	CHK	50,53	Csk_homologous_kinase	27,48	CHK	Csk homologous kinase	4145	4145	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of Csk_homologous_kinase -LRB- CHK -RRB- in normal brain and brain_tumors .
17003105	0	CHK1	0,4	CDC25B	20,26	CHK1	CDC25B	1111	994	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage .
25326330	0	CHK1	24,28	CLASPIN	54,61	CHK1	CLASPIN	1111	63967	Gene	Gene	activation|compound|START_ENTITY coordinates|dobj|activation coordinates|advcl|modulating modulating|dobj|stability stability|compound|END_ENTITY	HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability .
23109433	0	CHK1	19,23	CRL4	0,4	CHK1	CRL4	1111	55540	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	CRL4 -LRB- CDT2 -RRB- targets CHK1 for PCNA-independent destruction .
15526025	0	CHK1	21,25	Checkpoint_kinase_1	0,19	CHK1	Checkpoint kinase 1	1111	1111	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Checkpoint_kinase_1 -LRB- CHK1 -RRB- protein and mRNA expression is downregulated in aggressive variants of human lymphoid_neoplasms .
11158294	0	CHK1	19,23	p53	0,3	CHK1	p53	1111	7157	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	p53 down-regulates CHK1 through p21 and the retinoblastoma protein .
15659650	0	CHK1	34,38	p53	0,3	CHK1	p53	1111	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation .
19305158	0	CHK1	44,48	p53	71,74	CHK1	p53	1111	7157	Gene	Gene	inhibitor|compound|START_ENTITY Chir-124|appos|inhibitor Radiosensitization|nmod|Chir-124 Radiosensitization|dep|effects effects|nmod|checkpoints checkpoints|compound|END_ENTITY	Radiosensitization by Chir-124 , a selective CHK1 inhibitor : effects of p53 and cell cycle checkpoints .
19411857	0	CHK1	44,48	p53	142,145	CHK1	p53	1111	7157	Gene	Gene	START_ENTITY|nmod|carcinogens carcinogens|nmod|effect effect|nmod|END_ENTITY	Human_papilloma_virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53 .
20729914	0	CHK1	65,69	p53	10,13	CHK1	p53	1111	7157	Gene	Gene	inhibitors|nummod|START_ENTITY efficacy|nmod|inhibitors predict|dobj|efficacy predict|nsubj|Status Status|nmod|END_ENTITY	Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents .
26867682	0	CHK1	0,4	p53	50,53	CHK1	p53	1111	7157	Gene	Gene	expression|nummod|START_ENTITY modulated|nsubjpass|expression modulated|nmod|END_ENTITY	CHK1 expression in Gastric_Cancer is modulated by p53 and RB1/E2F1 : implications in chemo/radiotherapy response .
26921248	0	CHK1	0,4	p53	50,53	CHK1	p53	1111	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|NF-kB NF-kB|acl|signaling signaling|nmod|damage damage|nmod|END_ENTITY	CHK1 regulates NF-kB signaling upon DNA damage in p53 - deficient cells and associated tumor-derived microvesicles .
15668230	0	CHK2	14,18	DNA-dependent_protein_kinase	22,50	CHK2	DNA-dependent protein kinase	11200	5591	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of CHK2 by DNA-dependent_protein_kinase .
17074762	0	CHK2	46,50	EDD	0,3	CHK2	EDD	11200	51366	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	EDD mediates DNA damage-induced activation of CHK2 .
17940507	0	CHK2	59,63	EGFR	48,52	CHK2	EGFR	11200	1956	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	The predictive value of molecular markers -LRB- p53 , EGFR , ATM , CHK2 -RRB- in multimodally treated squamous_cell_carcinoma_of_the_oesophagus .
19996108	0	CHK2	49,53	TIMELESS	10,18	CHK2	TIMELESS	11200	8914	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control .
20160490	0	CHK2	23,27	phosphatase_2A	48,62	CHK2	phosphatase 2A	11200	5524	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Negative regulation of CHK2 activity by protein phosphatase_2A is modulated by DNA damage .
25740612	0	CHKB	50,54	choline_kinase_beta	29,48	CHKB	choline kinase beta	1120	1120	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	New splicing mutation in the choline_kinase_beta -LRB- CHKB -RRB- gene causing a muscular_dystrophy detected by whole-exome sequencing .
24971532	0	CHL1	16,20	miR-182	0,7	CHL1	miR-182	10752	406958	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-182 targets CHL1 and controls tumor growth and invasion in papillary_thyroid_carcinoma .
19363094	0	CHLI1	37,42	CHLI2	12,17	CHLI1	CHLI2	827580(Tax:3702)	834633(Tax:3702)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	Arabidopsis CHLI2 can substitute for CHLI1 .
26809558	0	CHLI1	121,126	CHLI2	93,98	CHLI1	CHLI2	5716878(Tax:3055)	5716573(Tax:3055)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	Mg chelatase in chlorophyll synthesis and retrograde signaling in Chlamydomonas_reinhardtii : CHLI2 can not substitute for CHLI1 .
19363094	0	CHLI2	12,17	CHLI1	37,42	CHLI2	CHLI1	834633(Tax:3702)	827580(Tax:3702)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	Arabidopsis CHLI2 can substitute for CHLI1 .
26809558	0	CHLI2	93,98	CHLI1	121,126	CHLI2	CHLI1	5716573(Tax:3055)	5716878(Tax:3055)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	Mg chelatase in chlorophyll synthesis and retrograde signaling in Chlamydomonas_reinhardtii : CHLI2 can not substitute for CHLI1 .
2265610	0	CHL_1	4,9	CTF_1	11,16	CHL 1	CTF 1	856099(Tax:4932)	856099(Tax:4932)	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	The CHL_1 -LRB- CTF_1 -RRB- gene product of Saccharomyces_cerevisiae is important for chromosome transmission and normal cell cycle progression in G2/M .
12827496	0	CHM	47,50	choroideremia	31,44	CHM	choroideremia	1121	1121	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel types of mutation in the choroideremia -LRB- CHM -RRB- gene : a full-length L1 insertion and an intronic mutation activating a cryptic exon .
9678418	0	CHM	113,116	choroideremia	98,111	CHM	choroideremia	1121	1121	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Altered rep-1 expression due to substitution at position +3 of the IVS13 splice-donor site of the choroideremia -LRB- CHM -RRB- gene .
17689859	0	CHM-1	0,5	matrix_metalloproteinase-9	121,147	CHM-1	matrix metalloproteinase-9	11061	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	CHM-1 inhibits hepatocyte_growth_factor-induced invasion of SK-Hep-1 human hepatocellular_carcinoma cells by suppressing matrix_metalloproteinase-9 expression .
8188272	0	CHML	35,39	choroideremia-like	15,33	CHML	choroideremia-like	1122	1122	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the choroideremia-like -LRB- CHML -RRB- gene at 1q42-qter and mutation analysis in patients with Usher_syndrome_type_II .
21616915	0	CHMP1B	19,25	Calpain-7	0,9	CHMP1B	Calpain-7	57132	23473	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Calpain-7 binds to CHMP1B at its second a-helical region and forms a ternary complex with IST1 .
18997780	0	CHMP1B	75,81	spastin	42,49	CHMP1B	spastin	57132	6683	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B .
22406677	0	CHMP4B	35,41	CC2D1A	0,6	CHMP4B	CC2D1A	128866	54862	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	CC2D1A is a regulator of ESCRT-III CHMP4B .
12860994	0	CHMP4b	51,57	Snf7	86,90	CHMP4b	Snf7	128866	850712(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The ALG-2-interacting protein Alix associates with CHMP4b , a human homologue of yeast Snf7 that is involved in multivesicular body sorting .
15511219	0	CHMP6	6,11	EAP20	94,99	CHMP6	EAP20	79643	84313	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human CHMP6 , a myristoylated ESCRT-III protein , interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting .
8570200	0	CHN	26,29	EWS	14,17	CHN	EWS	8013	2130	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Fusion of the EWS gene to CHN , a member of the steroid/thyroid receptor gene superfamily , in a human myxoid_chondrosarcoma .
7902402	0	CHO	91,94	CD2	86,89	CD2	CD2	914	914	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effects of low-doses of X-rays on the expression of human cell surface CD2 antigen in CD2 + CHO cells .
20654631	0	CHOP	24,28	ATF5	87,91	CHOP	ATF5	1649	22809	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the human CHOP gene promoter by the stress response transcription factor ATF5 via the AARE1 site in human hepatoma HepG2 cells .
20016232	0	CHOP	23,27	CHOP	41,45	CHOP	CHOP	1649	1649	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of biweekly CHOP and standard CHOP in different subgroups of diffuse large B-cell_lymphoma .
20016232	0	CHOP	41,45	CHOP	23,27	CHOP	CHOP	1649	1649	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of biweekly CHOP and standard CHOP in different subgroups of diffuse large B-cell_lymphoma .
11106111	0	CHOP	25,29	G-CSF	59,64	CHOP	G-CSF	1649	1440	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Dose-escalation study of CHOP with or without prophylactic G-CSF in aggressive non-Hodgkin 's _ lymphoma .
8898082	0	CHOP	22,26	GADD153	28,35	CHOP	GADD153	1649	1649	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Ectopic expression of CHOP -LRB- GADD153 -RRB- induces apoptosis in M1 myeloblastic_leukemia cells .
18396163	0	CHOP	72,76	JDP2	22,26	CHOP	JDP2	1649	122953	Gene	Gene	transcription|nmod|START_ENTITY Role|nmod|transcription Role|nmod|END_ENTITY	Role of the repressor JDP2 in the amino_acid-regulated transcription of CHOP .
26916663	0	CHOP	89,93	Neurod1	70,77	CHOP	Neurod1	1649	4760	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Epigallocatechin-3-gallate Inhibits Ethanol-induced apoptosis through Neurod1 Regulating CHOP Expression in Pancreatic b-cells .
17109853	0	CHOP	119,123	PI3K	96,100	CHOP	PI3K	1649	5293	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Inhibitory effect of 4 - -LRB- 2-aminoethyl -RRB- - benzenesulfonyl_fluoride , a serine protease inhibitor , on PI3K inhibitor-induced CHOP expression .
7958914	0	CHOP	108,112	TLS	53,56	CHOP	TLS	1649	2521	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|domain domain|nmod|END_ENTITY	A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP .
23261452	0	CHOP	73,77	death_receptor_5	118,134	CHOP	death receptor 5	1649	8795	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP - and p38 MAPK-mediated up-regulation of death_receptor_5 in malignant_glioma .
20424162	0	CHOP	65,69	interleukin-1_beta	85,103	CHOP	interleukin-1 beta	1649	3553	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulation of CCAAT/enhancer-binding _ protein_homologous_protein -LRB- CHOP -RRB- expression by interleukin-1_beta in pancreatic beta cells .
17615236	0	CHOP-10	27,34	GADD153	35,42	CHOP-10	GADD153	1649	1649	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|expression expression|compound|END_ENTITY	Differential regulation of CHOP-10 / GADD153 gene expression by MAPK signaling in pancreatic beta-cells .
10542372	0	CHOP-10	16,23	gadd153	25,32	CHOP-10	gadd153	13198(Tax:10090)	13198(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Upregulation of CHOP-10 -LRB- gadd153 -RRB- expression in the mouse blastocyst as a response to stress .
18762859	0	CHRNA4	126,132	alpha4	48,54	CHRNA4	alpha4	1137	3476	Gene	Gene	genes|appos|START_ENTITY analysis|nmod|genes analysis|nmod|subunits subunits|amod|END_ENTITY	Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes -LRB- CHRNA4 and CHRNB2 -RRB- with schizophrenia in the Japanese population .
12049804	0	CHRNA7	44,50	EJM2	93,97	CHRNA7	EJM2	1139	50715	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of the positional candidate gene CHRNA7 at the juvenile_myoclonic_epilepsy locus -LRB- EJM2 -RRB- on chromosome 15q13-14 .
9782083	0	CHRNA7	113,119	alpha7_neuronal_nicotinic_acetylcholine_receptor	58,106	CHRNA7	alpha7 neuronal nicotinic acetylcholine receptor	1139	1139	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and partial duplication of the human alpha7_neuronal_nicotinic_acetylcholine_receptor gene -LRB- CHRNA7 -RRB- .
9921897	0	CHRNB2	103,109	neuronal_nicotinic_acetylcholine_receptor_beta2	28,75	CHRNB2	neuronal nicotinic acetylcholine receptor beta2	1141	1141	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The structures of the human neuronal_nicotinic_acetylcholine_receptor_beta2 - and alpha3-subunit genes -LRB- CHRNB2 and CHRNA3 -RRB- .
15896657	0	CHS1	10,14	LYST	16,20	CHS1	LYST	1130	1130	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Two novel CHS1 -LRB- LYST -RRB- mutations : clinical correlations in an infant with Chediak-Higashi_syndrome .
20345602	0	CHS8	62,66	MYB_transcription_factor	16,40	CHS8	MYB transcription factor	100170701(Tax:3847)	100780023	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	A single-repeat MYB_transcription_factor , GmMYB176 , regulates CHS8 gene expression and affects isoflavonoid biosynthesis in soybean .
25511584	0	CHST11	46,52	chondroitin-4-sulfotransferase	14,44	CHST11	chondroitin-4-sulfotransferase	50515	50515	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
20842734	0	CHST14	210,216	dermatan-4-sulfotransferase_1	171,200	CHST14	dermatan-4-sulfotransferase 1	113189	113189	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Musculocontractural Ehlers-Danlos_Syndrome -LRB- former EDS type VIB -RRB- and adducted thumb clubfoot_syndrome -LRB- ATCS -RRB- represent a single clinical entity caused by mutations in the dermatan-4-sulfotransferase_1 encoding CHST14 gene .
14735064	0	CHST6	56,61	carbohydrate_sulfotransferase-6	23,54	CHST6	carbohydrate sulfotransferase-6	4166	4166	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations of the carbohydrate_sulfotransferase-6 -LRB- CHST6 -RRB- gene causing macular corneal_dystrophy in India .
15953452	0	CHST6	56,61	carbohydrate_sulfotransferase_6	23,54	CHST6	carbohydrate sulfotransferase 6	4166	4166	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Different mutations in carbohydrate_sulfotransferase_6 -LRB- CHST6 -RRB- gene cause macular corneal_dystrophy_types_I and II in a single sibship .
26356269	0	CHSY1	63,68	Chondroitin_Sulfate_Synthase_1	31,61	CHSY1	Chondroitin Sulfate Synthase 1	292999(Tax:10116)	292999(Tax:10116)	Gene	Gene	Up-Regulation|appos|START_ENTITY Up-Regulation|nmod|END_ENTITY	TGF-b Induces Up-Regulation of Chondroitin_Sulfate_Synthase_1 -LRB- CHSY1 -RRB- in Nucleus Pulposus Cells Through MAPK Signaling .
22361880	0	CHT1	38,42	Nedd4-2	80,87	CHT1	Nedd4-2	60482	23327	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2 .
15073177	0	CIA	72,75	TIP30	0,5	CIA	TIP30	228869(Tax:10090)	53415(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TIP30 interacts with an estrogen_receptor_alpha-interacting coactivator CIA and regulates c-myc transcription .
18293492	0	CIAPIN1	0,7	CyclinD1	96,104	CIAPIN1	CyclinD1	57019	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	CIAPIN1 inhibits gastric_cancer cell proliferation and cell cycle progression by downregulating CyclinD1 and upregulating P27 .
17178985	0	CIAS-1	117,123	NALP3	124,129	CIAS-1	NALP3	114548	114548	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Phenotype , genotype , and sustained response to anakinra in 22 patients with autoinflammatory_disease associated with CIAS-1 / NALP3 mutations .
16868559	0	CIAS1	108,113	cold-induced_autoinflammatory_syndrome_1	66,106	CIAS1	cold-induced autoinflammatory syndrome 1	114548	114548	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An intronic variable number of tandem repeat polymorphisms of the cold-induced_autoinflammatory_syndrome_1 -LRB- CIAS1 -RRB- gene modifies gene expression and is associated with essential hypertension .
21035374	0	CIAS1	107,112	cold-induced_autoinflammatory_syndrome_1	65,105	CIAS1	cold-induced autoinflammatory syndrome 1	114548	114548	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Distribution of 42-bp variable tandem repeat polymorphism of the cold-induced_autoinflammatory_syndrome_1 -LRB- CIAS1 -RRB- gene in eight human populations .
11756406	0	CIB	66,69	Rac3	17,21	CIB	Rac3	10519	5881	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha -LRB- IIb -RRB- beta -LRB- 3 -RRB- - mediated adhesion and spreading .
18988809	0	CIB1	33,37	CRY2	13,17	CIB1	CRY2	829604(Tax:3702)	839529(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis .
24101505	0	CIB1	83,87	CRY2	12,16	CIB1	CRY2	829604(Tax:3702)	839529(Tax:3702)	Gene	Gene	regulation|nmod|START_ENTITY mediate|dobj|regulation mediate|nsubj|END_ENTITY	Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms .
15592865	0	CID	110,113	Cap-G	46,51	CID	Cap-G	36495(Tax:7227)	36440(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Drosophila_melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID .
26099526	0	CIDEC	24,29	Fat-Specific_Protein_27	0,23	CIDEC	Fat-Specific Protein 27	14311(Tax:10090)	14311(Tax:10090)	Gene	Gene	Development|compound|START_ENTITY END_ENTITY|dep|Development	Fat-Specific_Protein_27 / CIDEC Promotes Development of Alcoholic_Steatohepatitis in Mice and Humans .
27062372	0	CIDEC	20,25	TNF-a	0,5	CIDEC	TNF-a	63924	7124	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	TNF-a downregulates CIDEC via MEK/ERK pathway in human adipocytes .
24229606	0	CIDEC	22,27	insulin	31,38	CIDEC	insulin	63924	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- Research advances on CIDEC in insulin resistance -RSB- .
17403899	0	CIF-1	0,5	MEL-26	104,110	CIF-1	MEL-26	177236(Tax:6239)	172737(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	CIF-1 , a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes , regulates MEL-26 levels in the Caenorhabditis_elegans embryo .
11053628	0	CIITA	180,185	IFN-gamma	142,151	CIITA	IFN-gamma	4261	3458	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter -LRB- PIV -RRB- of CIITA .
15661876	0	CIITA	61,66	IL-10	23,28	CIITA	IL-10	12265(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Enhanced production of IL-10 by dendritic_cells_deficient in CIITA .
17346795	0	CIITA	40,45	PKCdelta	8,16	CIITA	PKCdelta	4261	5580	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of PKCdelta in IFN-gamma-inducible CIITA gene expression .
24036077	0	CIITA	28,33	TAF1	59,63	CIITA	TAF1	4261	6872	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Transcriptional coactivator CIITA , a functional homolog of TAF1 , has kinase activity .
9171108	0	CIITA	29,34	TAFII32	76,83	CIITA	TAFII32	4261	6880	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32 .
22851713	0	CIITA	36,41	ZBTB32	0,6	CIITA	ZBTB32	12265(Tax:10090)	58206(Tax:10090)	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells .
12391222	0	CIITA	64,69	class_II_trans-activator	38,62	CIITA	class II trans-activator	4261	4261	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of the MHC class_II_trans-activator -LRB- CIITA -RRB- promoter III : identification of a novel regulatory region in the 5 ' - untranslated region and an important role for cAMP-responsive_element_binding_protein_1 and activating_transcription_factor-1 in CIITA-promoter III transcriptional activation in B lymphocytes .
11514596	0	CIITA	108,113	class_II_transactivator	83,106	CIITA	class II transactivator	4261	4261	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class_II_transactivator -LRB- CIITA -RRB- expression .
12102254	0	CIITA	41,46	class_II_transactivator	16,39	CIITA	class II transactivator	12265(Tax:10090)	12265(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the class_II_transactivator -LRB- CIITA -RRB- in MHC class I and II regulation and graft rejection in kidney .
12493643	0	CIITA	88,93	class_II_transactivator	63,86	CIITA	class II transactivator	4261	4261	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	The IRF-2 DNA binding domain facilitates the activation of the class_II_transactivator -LRB- CIITA -RRB- type IV promoter by IRF-1 .
14757364	0	CIITA	43,48	class_II_transactivator	18,41	CIITA	class II transactivator	12265(Tax:10090)	12265(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Downregulation of class_II_transactivator -LRB- CIITA -RRB- expression by synthetic cannabinoid CP55 ,940 .
15467734	0	CIITA	52,57	class_II_transactivator	27,50	CIITA	class II transactivator	4261	4261	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Epigenetic inactivation of class_II_transactivator -LRB- CIITA -RRB- is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal_and_gastric_cancer cells .
23524893	0	CIITA	109,114	class_II_transactivator	84,107	CIITA	class II transactivator	85483(Tax:10116)	85483(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Downregulating immunogenicity of Schwann cells via inhibiting a potential target of class_II_transactivator -LRB- CIITA -RRB- gene .
17991736	0	CIITA	0,5	interferon-gamma	15,31	CIITA	interferon-gamma	4261	3458	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|repression repression|amod|END_ENTITY	CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules .
16413503	0	CILP	72,76	cartilage_intermediate_layer_protein	34,70	CILP	cartilage intermediate layer protein	8483	8483	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the cartilage_intermediate_layer_protein -LRB- CILP -RRB- gene .
21275903	0	CIN85	23,28	ARAP1	0,5	CIN85	ARAP1	30011	116985	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	ARAP1 association with CIN85 affects epidermal_growth_factor_receptor endocytic trafficking .
17306257	0	CIN85	48,53	Abl-SH3_binding_protein_2	0,25	CIN85	Abl-SH3 binding protein 2	30011	6452	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Abl-SH3_binding_protein_2 , 3BP2 , interacts with CIN85 and HIP-55 .
14596919	0	CIN85	11,16	Dab2	0,4	CIN85	Dab2	30011	1601	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Dab2 links CIN85 with clathrin-mediated receptor internalization .
23506116	0	CIN85	54,59	Reelin	65,71	CIN85	Reelin	30011	5649	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors , ApoER2 and VLDLR , in neurons .
26169354	0	CIN85	0,5	TGFb	16,20	CIN85	TGFb	30011	7040	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	CIN85 modulates TGFb signaling by promoting the presentation of TGFb receptors on the cell surface .
26169354	0	CIN85	0,5	TGFb	64,68	CIN85	TGFb	30011	7040	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|TGFb TGFb|acl|signaling signaling|advcl|promoting promoting|dobj|presentation presentation|nmod|receptors receptors|compound|END_ENTITY	CIN85 modulates TGFb signaling by promoting the presentation of TGFb receptors on the cell surface .
9576061	0	CINC-2	103,109	cytokine-induced_neutrophil_chemoattractant-2	56,101	CINC-2	cytokine-induced neutrophil chemoattractant-2	171551(Tax:10116)	171551(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gene structure , cDNA cloning , and expression of the rat cytokine-induced_neutrophil_chemoattractant-2 -LRB- CINC-2 -RRB- gene .
11700040	0	CIP1	37,41	INK4	23,27	CIP1	INK4	1026	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Influence of human p16 -LRB- INK4 -RRB- and p21 -LRB- CIP1 -RRB- on the in vitro activity of recombinant Plasmodium_falciparum cyclin-dependent protein kinases .
10022865	6	CIP1	967,971	p21	963,966	CIP1	p21	1026	1026	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	In agreement with this hypothesis , overexpression of p21 -LRB- CIP1 -RRB- in 293 cells , where CDK4 is bound to p16 -LRB- INK4a -RRB- , stimulates the formation of ternary cyclin D-CDK4-p21 -LRB- CIP1 -RRB- complexes .
10806303	0	CIP1	41,45	p21	37,40	CIP1	p21	1026	1026	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Growth factor-dependent induction of p21 -LRB- CIP1 -RRB- by the green tea polyphenol , epigallocatechin_gallate .
22146591	0	CIP1	86,90	p21	82,85	CIP1	p21	1026	644914	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21 -LRB- CIP1 -RRB- pathway .
23759594	0	CIP1	53,57	p38	11,14	CIP1	p38	1026	1432	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for p38 in transcriptional elongation of p21 -LRB- CIP1 -RRB- in response to Aurora_B inhibition .
25458953	0	CIP2A	0,5	H-Ras	22,27	CIP2A	H-Ras	57650	3265	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	CIP2A cooperates with H-Ras to promote epithelial-mesenchymal transition in cervical-cancer progression .
17632056	0	CIP2A	0,5	PP2A	15,19	CIP2A	PP2A	57650	5524	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	CIP2A inhibits PP2A in human malignancies .
12641734	0	CIP98	0,5	calmodulin-dependent_serine_kinase	97,131	CIP98	calmodulin-dependent serine kinase	25861	8573	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CIP98 , a novel PDZ domain protein , is expressed in the central nervous system and interacts with calmodulin-dependent_serine_kinase .
15652350	0	CIR	0,3	CBF1	22,26	CIR	CBF1	9541	3516	Gene	Gene	START_ENTITY|appos|corepressor corepressor|nmod|END_ENTITY	CIR , a corepressor of CBF1 , binds to PAP-1 and effects alternative splicing .
17587236	0	CIR1	27,31	RVE2	33,37	CIR1	RVE2	833700(Tax:3702)	833700(Tax:3702)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive expression of CIR1 -LRB- RVE2 -RRB- affects several circadian-regulated processes and seed germination in Arabidopsis .
18460819	0	CIRCADIAN_CLOCK-ASSOCIATED_1	69,97	CCA1	63,67	CIRCADIAN CLOCK-ASSOCIATED 1	CCA1	819296(Tax:3702)	819296(Tax:3702)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	The function of the clock-associated transcriptional regulator CCA1 -LRB- CIRCADIAN_CLOCK-ASSOCIATED_1 -RRB- in Arabidopsis_thaliana .
9657153	0	CIRCADIAN_CLOCK_ASSOCIATED_1	31,59	CCA1	61,65	CIRCADIAN CLOCK ASSOCIATED 1	CCA1	819296(Tax:3702)	819296(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Constitutive expression of the CIRCADIAN_CLOCK_ASSOCIATED_1 -LRB- CCA1 -RRB- gene disrupts circadian rhythms and suppresses its own expression .
25934796	0	CIRP	50,54	Cold-Inducible_RNA-Binding_Protein	14,48	CIRP	Cold-Inducible RNA-Binding Protein	1153	1153	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Cold-Inducible_RNA-Binding_Protein -LRB- CIRP -RRB- in Pituitary_Adenoma and its Relationships with Tumor Recurrence .
19398494	0	CIRP	36,40	Cold-inducible_RNA_binding_protein	0,34	CIRP	Cold-inducible RNA binding protein	12696(Tax:10090)	12696(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cold-inducible_RNA_binding_protein -LRB- CIRP -RRB- expression is modulated by alternative mRNAs .
9422546	0	CIRP	60,64	cold-inducible_RNA-binding_protein	24,58	CIRP	cold-inducible RNA-binding protein	12696(Tax:10090)	12696(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of cold-inducible_RNA-binding_protein -LRB- CIRP -RRB- in male germ cells at elevated temperature .
11245630	0	CIS1	93,97	STAT5	76,81	CIS1	STAT5	1154	6776	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Granulocyte_macrophage_colony-stimulating_factor and interleukin-5 activate STAT5 and induce CIS1 mRNA in human peripheral blood eosinophils .
19293151	0	CISK	90,94	Flightless-I	18,30	CISK	Flightless-I	23678	2314	Gene	Gene	substrate|nmod|START_ENTITY Identification|nmod|substrate Identification|nmod|END_ENTITY	Identification of Flightless-I as a substrate of the cytokine-independent_survival_kinase CISK .
11514587	0	CISK	52,56	cytokine-independent_survival_kinase	14,50	CISK	cytokine-independent survival kinase	23678	23678	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cytokine-independent_survival_kinase -LRB- CISK -RRB- by the Phox homology domain and phosphoinositides .
25049079	0	CITED1	54,60	parathyroid_hormone	72,91	CITED1	parathyroid hormone	12705(Tax:10090)	19226(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Nuclear translocation of CBP/p300-interacting protein CITED1 induced by parathyroid_hormone requires serine phosphorylation at position 79 in its 63-84 domain .
25907930	0	CITED1	110,116	parathyroid_hormone	81,100	CITED1	parathyroid hormone	12705(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY enhances|dobj|expression enhances|nsubj|Activation Activation|nmod|C C|acl|signaling signaling|dobj|pathway pathway|nmod|END_ENTITY	-LSB- Activation of phospholipase C-independent protein kinase C signaling pathway of parathyroid_hormone enhances CITED1 expression in mouse osteoblasts -RSB- .
14594809	0	CITED2	89,95	CREB-binding_protein	38,58	CITED2	CREB-binding protein	10370	1387	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Interaction of the TAZ1 domain of the CREB-binding_protein with the activation domain of CITED2 : regulation by competition between intrinsically unstructured ligands for non-identical binding sites .
15051727	0	CITED2	68,74	CREB-binding_protein	22,42	CITED2	CREB-binding protein	17684(Tax:10090)	12914(Tax:10090)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of the CREB-binding_protein / p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator .
26687824	0	CITED2	133,139	MMP-1	158,163	CITED2	MMP-1	10370	4312	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Strain-induced mechanotransduction through primary cilia , extracellular ATP , purinergic calcium signaling , and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes .
23811274	0	CITED2	0,6	estrogen_receptor	17,34	CITED2	estrogen receptor	10370	2099	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	CITED2 modulates estrogen_receptor transcriptional activity in breast_cancer cells .
26450995	0	CITED2	23,29	miR-200b	49,57	CITED2	miR-200b	10370	406984	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	High glucose-repressed CITED2 expression through miR-200b triggers the unfolded protein response and endoplasmic reticulum stress .
18495890	0	CITED2	0,6	peroxisome_proliferator-activated_receptor-gamma	23,71	CITED2	peroxisome proliferator-activated receptor-gamma	10370	5468	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	CITED2 signals through peroxisome_proliferator-activated_receptor-gamma to regulate death of cortical neurons after DNA damage .
11112339	0	CIZ	55,58	Cas-interacting_zinc_finger_protein	18,53	CIZ	Cas-interacting zinc finger protein	269800(Tax:10090)	269800(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Cas-interacting_zinc_finger_protein -LRB- CIZ -RRB- suppresses proliferation and enhances expression of type I collagen gene in osteoblast-like MC3T3E1 cells .
26861296	0	CIZ1	54,58	Cdkn1A-Interacting_Zinc_Finger_Protein_1	12,52	CIZ1	Cdkn1A-Interacting Zinc Finger Protein 1	25792	25792;1026	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Cdkn1A-Interacting_Zinc_Finger_Protein_1 -LRB- CIZ1 -RRB- in DNA Replication and Pathophysiology .
26906552	0	CIZ1	0,4	YAP	20,23	CIZ1	YAP	25792	10413	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CIZ1 interacts with YAP and activates its transcriptional activity in hepatocellular_carcinoma cells .
26580434	0	CK-M	78,82	Creatine_Kinase_Muscle	54,76	CK-M	Creatine Kinase Muscle	100065641(Tax:9796)	100065641(Tax:9796)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Molecular Characterization and Expression Analysis of Creatine_Kinase_Muscle -LRB- CK-M -RRB- Gene in Horse .
21252624	0	CK1	0,3	Cdc25A	14,20	CK1	Cdc25A	1452	993	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	CK1 targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation .
26892600	0	CK1	58,61	Dvl2	64,68	CK1	Dvl2	3848	1856	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	DDX3 promotes tumor invasion in colorectal_cancer via the CK1 / Dvl2 axis .
18246126	0	CK1	38,41	PML	0,3	CK1	PML	122011	5371	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	PML enhances the regulation of p53 by CK1 in response to DNA damage .
22113361	0	CK1	39,42	casein_kinase_1	20,35	CK1	casein kinase 1	122011	122011	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association of a casein_kinase_1 -LRB- CK1 -RRB- gene polymorphism with personality traits in healthy Chinese-Han subjects .
21670201	0	CK1	59,62	p120-catenin	94,106	CK1	p120-catenin	122011	1500	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Wnt controls the transcriptional activity of Kaiso through CK1 - dependent phosphorylation of p120-catenin .
26905970	0	CK1	59,62	p120-catenin	94,106	CK1	p120-catenin	3848	1500	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Wnt controls the transcriptional activity of Kaiso through CK1 - dependent phosphorylation of p120-catenin .
20305697	0	CK1	8,11	snail	68,73	CK1	snail	3848	6615	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail .
20644217	0	CK19	27,31	RET	33,36	CK19	RET	3880	5979	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Diagnostic significance of CK19 , RET , galectin-3 and HBME-1 expression for papillary_thyroid_carcinoma .
15961172	0	CK1_delta	38,47	casein_kinase_1_delta	15,36	CK1 delta	casein kinase 1 delta	1453	1453	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of casein_kinase_1_delta -LRB- CK1_delta -RRB- with the light chain LC2 of microtubule_associated_protein_1A -LRB- MAP1A -RRB- .
15687492	0	CK1alpha	15,23	heterogeneous_nuclear_ribonucleoprotein_C	50,91	CK1alpha	heterogeneous nuclear ribonucleoprotein C	1452	3183	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Protein kinase CK1alpha regulates mRNA binding by heterogeneous_nuclear_ribonucleoprotein_C in response to physiologic levels of hydrogen_peroxide .
26206296	0	CK1d	85,89	casein_kinase_1_delta	62,83	CK1d	casein kinase 1 delta	1453	1453	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Computer-aided scaffold hopping to identify a novel series of casein_kinase_1_delta -LRB- CK1d -RRB- inhibitors for amyotrophic_lateral_sclerosis .
10826492	0	CK1delta	38,46	casein_kinase_1_delta	15,36	CK1delta	casein kinase 1 delta	1453	1453	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of casein_kinase_1_delta -LRB- CK1delta -RRB- with post-Golgi structures , microtubules and the spindle apparatus .
24395637	0	CK2	12,15	Ankyrin2	73,81	CK2	Ankyrin2	48448(Tax:7227)	38863(Tax:7227)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2 .
9058200	0	CK2	53,56	CaBP1	19,24	CK2	CaBP1	13000(Tax:10090)	9478	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of CaBP1 and CaBP2 by protein kinase CK2 .
16342413	0	CK2	11,14	Deadpan	30,37	CK2	Deadpan	48448(Tax:7227)	35800(Tax:7227)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Drosophila CK2 phosphorylates Deadpan , a member of the HES family of basic-helix-loop-helix -LRB- bHLH -RRB- repressors .
11284721	0	CK2	95,98	MDM2	49,53	CK2	MDM2	13000(Tax:10090)	17246(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Phosphorylation of murine double minute clone 2 -LRB- MDM2 -RRB- protein at serine-267 by protein kinase CK2 in vitro and in cultured cells .
23553788	0	CK2	15,18	Mcl-1	28,33	CK2	Mcl-1	81650(Tax:10116)	60430(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Protein kinase CK2 enhances Mcl-1 gene expression through the serum_response_factor-mediated pathway in the rat hippocampus .
17443683	0	CK2	95,98	Parathyroid_hormone-related_protein	0,35	CK2	Parathyroid hormone-related protein	13000(Tax:10090)	5744	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- inhibits mitochondrial-dependent apoptosis through CK2 .
15325264	0	CK2	15,18	SAP90	72,77	CK2	SAP90	81650(Tax:10116)	29495(Tax:10116)	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Protein kinase CK2 in postsynaptic densities : phosphorylation of PSD-95 / SAP90 and NMDA receptor regulation .
12571244	0	CK2	15,18	SSRP1	73,78	CK2	SSRP1	100384477(Tax:4577)	542007(Tax:4577)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Protein kinase CK2 phosphorylates the high mobility group domain protein SSRP1 , inducing the recognition of UV-damaged DNA .
14647065	0	CK2	14,17	TGF-beta1	30,39	CK2	TGF-beta1	13000(Tax:10090)	21803(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes .
10491082	1	CK2	92,95	cingulin	117,125	CK2	cingulin	399320(Tax:8355)	398149(Tax:8355)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin .
15034923	0	CK2	91,94	p27KIP1	30,37	CK2	p27KIP1	399320(Tax:8355)	1027	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2 .
16980943	0	CK20	146,150	CDX2	34,38	CK20	CDX2	54474	1045	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|nmod|END_ENTITY	Immunohistochemical expression of CDX2 in primary ovarian_mucinous_tumors and metastatic mucinous_carcinomas involving the ovary : comparison with CK20 and correlation with coordinate expression of CK7 .
14631371	0	CK20	46,50	CK7	41,44	CK20	CK7	54474	3855	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Identical cytokeratin expression pattern CK7 + / CK20 - in esophageal and cardiac_cancer : etiopathological and clinical implications .
16980943	0	CK20	146,150	CK7	197,200	CK20	CK7	54474	3855	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|expression expression|nmod|END_ENTITY	Immunohistochemical expression of CDX2 in primary ovarian_mucinous_tumors and metastatic mucinous_carcinomas involving the ovary : comparison with CK20 and correlation with coordinate expression of CK7 .
18001414	0	CK20	47,51	CK7	53,56	CK20	CK7	54474	3855	Gene	Gene	series|nmod|START_ENTITY series|dep|neuroendocrine_carcinoma neuroendocrine_carcinoma|compound|END_ENTITY	A case series and immunophenotypic analysis of CK20 - / CK7 + primary neuroendocrine_carcinoma of the skin .
22591041	0	CK20	44,48	CK7	39,42	CK20	CK7	54474	3855	Gene	Gene	Ki67|dep|START_ENTITY Ki67|compound|END_ENTITY	Evaluation of Barrett 's _ esophagus with CK7 , CK20 , p53 , Ki67 , and COX2 expressions using chromoendoscopical examination .
26711206	0	CK20	6,10	CK7	1,4	CK20	CK7	54474	3855	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CK7 , CK20 , SOX10 and CDX2 : expressions and diagnostic values in primary adenocarcinoma of the sinonasal tract -RSB- .
26711206	0	CK20	6,10	SOX10	12,17	CK20	SOX10	54474	6663	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CK7 , CK20 , SOX10 and CDX2 : expressions and diagnostic values in primary adenocarcinoma of the sinonasal tract -RSB- .
22591041	0	CK20	44,48	p53	50,53	CK20	p53	54474	7157	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	Evaluation of Barrett 's _ esophagus with CK7 , CK20 , p53 , Ki67 , and COX2 expressions using chromoendoscopical examination .
9178172	0	CK4	44,47	p53	14,17	CK4	p53	3851	7157	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of p53 , Ki-67 and cytokeratin-4 -LRB- CK4 -RRB- in oral_papillomas .
15494931	7	CK5	1251,1254	TTF-1	1256,1261	CK7	TTF-1	3855	7270	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Most nonepidermoid tumors had the `` lung-specific '' phenotype CK5 - / TTF-1 + ; all small_cell_carcinomas had the phenotype CK5 - / CK8 + / TTF-1 + , all adenocarcinomas CK5 - / CK7 + / TTF-1 + and -LRB- more than 50 % -RRB- of LCC CK5 - / CK7 + / TTF-1 + .
22582081	0	CK5	48,51	TTF-1	21,26	CK5	TTF-1	3852	7270	Gene	Gene	START_ENTITY|nsubj|A A|compound|END_ENTITY	Dual color multiplex TTF-1 + Napsin A and p63 + CK5 immunostaining for subcategorizing of poorly differentiated pulmonary_non-small_carcinomas into adenocarcinoma and squamous_cell_carcinoma in fine needle aspiration specimens .
16183870	0	CK7	14,17	CD200	7,12	CK7	CD200	110310(Tax:10090)	17470(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Murine CD200 + CK7 + trophoblasts in a poly -LRB- I : C -RRB- - induced embryo resorption model .
14631371	0	CK7	41,44	CK20	46,50	CK7	CK20	3855	54474	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Identical cytokeratin expression pattern CK7 + / CK20 - in esophageal and cardiac_cancer : etiopathological and clinical implications .
16980943	0	CK7	197,200	CK20	146,150	CK7	CK20	3855	54474	Gene	Gene	expression|nmod|START_ENTITY comparison|nmod|expression comparison|nmod|END_ENTITY	Immunohistochemical expression of CDX2 in primary ovarian_mucinous_tumors and metastatic mucinous_carcinomas involving the ovary : comparison with CK20 and correlation with coordinate expression of CK7 .
18001414	0	CK7	53,56	CK20	47,51	CK7	CK20	3855	54474	Gene	Gene	neuroendocrine_carcinoma|compound|START_ENTITY series|dep|neuroendocrine_carcinoma series|nmod|END_ENTITY	A case series and immunophenotypic analysis of CK20 - / CK7 + primary neuroendocrine_carcinoma of the skin .
22591041	0	CK7	39,42	CK20	44,48	CK7	CK20	3855	54474	Gene	Gene	Ki67|compound|START_ENTITY Ki67|dep|END_ENTITY	Evaluation of Barrett 's _ esophagus with CK7 , CK20 , p53 , Ki67 , and COX2 expressions using chromoendoscopical examination .
26711206	0	CK7	1,4	CK20	6,10	CK7	CK20	3855	54474	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CK7 , CK20 , SOX10 and CDX2 : expressions and diagnostic values in primary adenocarcinoma of the sinonasal tract -RSB- .
26711206	0	CK7	1,4	SOX10	12,17	CK7	SOX10	3855	6663	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CK7 , CK20 , SOX10 and CDX2 : expressions and diagnostic values in primary adenocarcinoma of the sinonasal tract -RSB- .
22591041	0	CK7	39,42	p53	50,53	CK7	p53	3855	7157	Gene	Gene	Ki67|compound|START_ENTITY Ki67|dep|END_ENTITY	Evaluation of Barrett 's _ esophagus with CK7 , CK20 , p53 , Ki67 , and COX2 expressions using chromoendoscopical examination .
22465120	0	CKAP2	56,61	Cyclin_A	0,8	CKAP2	Cyclin A	26586	890	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cyclin_A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1 .
12500535	0	CKAP2	51,56	LB1	58,61	CKAP2	LB1	26586	26586	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- The structure of the human oncogenesis-associated CKAP2 -LRB- LB1 -RRB- gene -RSB- .
21143984	0	CKAP4	86,91	Akt	35,38	CKAP4	Akt	10970	207	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Antiproliferative factor decreases Akt phosphorylation and alters gene expression via CKAP4 in T24 bladder_carcinoma cells .
18708633	0	CKAP4	13,18	P63	8,11	CKAP4	P63	10970	10970	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of P63 -LRB- CKAP4 -RRB- in binding of surfactant_protein-A to type II pneumocytes .
12000790	0	CKI	14,17	beta-catenin	37,49	CKI	beta-catenin	1119	1499	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45 : a molecular switch for the Wnt pathway .
12748192	0	CKII	74,78	IkappaBalpha	107,119	CKII	IkappaBalpha	1457	4792	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2 / Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1 .
12432063	0	CKII	15,19	alpha-catenin	67,80	CKII	alpha-catenin	1457	1495	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability .
11485312	0	CKII	29,33	p47	86,89	CKII	p47	1457	5341	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Regulation of protein_kinase CKII by direct interaction with the C-terminal region of p47 -LRB- phox -RRB- .
11485312	0	CKII	29,33	protein_kinase	14,28	CKII	protein kinase	1457	1022	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of protein_kinase CKII by direct interaction with the C-terminal region of p47 -LRB- phox -RRB- .
20510015	0	CKII	65,69	protein_kinase	50,64	CKII	protein kinase	1457	1022	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Capsaicin , a component of red peppers , stimulates protein_kinase CKII activity .
7735325	0	CKII	29,33	protein_kinase	14,28	CKII	protein kinase	1457	1022	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of protein_kinase CKII during the cell division cycle .
16641266	0	CKII_alpha	21,31	NS1	0,3	CKII alpha	NS1	1459	10625	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	NS1 interaction with CKII_alpha : novel protein complex mediating parvovirus-induced cytotoxicity .
16325375	0	CKIP-1	0,6	ATM	24,27	CKIP-1	ATM	51177	472	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM .
26160174	0	CKIP-1	62,68	p21-activated_Kinase_1	86,108	CKIP-1	p21-activated Kinase 1	51177	5058	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of the Pleckstrin Homology Domain-Containing Protein CKIP-1 in Activation of p21-activated_Kinase_1 -LRB- PAK1 -RRB- .
21168207	0	CKLF-like_MARVEL_transmembrane_member_5	23,62	CMTM5	64,69	CKLF-like MARVEL transmembrane member 5	CMTM5	116173	116173	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Aberrant expression of CKLF-like_MARVEL_transmembrane_member_5 -LRB- CMTM5 -RRB- by promoter methylation in myeloid_leukemia .
14980499	0	CKLiK	81,86	calcium-calmodulin-dependent_kinase_I-like_kinase	30,79	CKLiK	calcium-calmodulin-dependent kinase I-like kinase	227541(Tax:10090)	227541(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of PU.1-induced mouse calcium-calmodulin-dependent_kinase_I-like_kinase -LRB- CKLiK -RRB- on apoptosis of murine_erythroleukemia cells .
22898779	0	CKS1	33,37	CKS2	16,20	CKS1	CKS2	54124(Tax:10090)	66197(Tax:10090)	Gene	Gene	counteracts|dobj|START_ENTITY counteracts|nsubj|END_ENTITY	The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment .
22898779	0	CKS2	16,20	CKS1	33,37	CKS2	CKS1	66197(Tax:10090)	54124(Tax:10090)	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	The CDK subunit CKS2 counteracts CKS1 to control cyclin A/CDK2 activity in maintaining replicative fidelity and neurodevelopment .
19951712	0	CK_beta_8	0,9	CCL23	10,15	CK beta 8	CCL23	6368	6368	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	CK_beta_8 / CCL23 induces cell migration via the Gi/Go _ protein/PLC/PKC _ delta/NF-kappa _ B and is involved in inflammatory responses .
10737895	0	CKbeta-8	0,8	CCL23	10,15	CKbeta-8	CCL23	6368	6368	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	CKbeta-8 -LSB- CCL23 -RSB- , a novel CC chemokine , is chemotactic for human osteoclast precursors and is expressed in bone tissues .
9126480	0	CL-20	97,102	EMP1	109,113	CL-20	EMP1	2012	2012	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	cDNA cloning , genomic structure , and chromosome mapping of the human epithelial membrane protein CL-20 gene -LRB- EMP1 -RRB- , a member of the PMP22 family .
9268630	0	CL-6	81,85	INSIG1	86,92	CL-6	INSIG1	3638	3638	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Cloning , human chromosomal assignment , and adipose and hepatic expression of the CL-6 / INSIG1 gene .
17638884	0	CL100	31,36	E2F-1	75,80	CL100	E2F-1	1843	1869	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Dual_specificity_phosphatase_1 / CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress .
16197392	0	CLA	42,45	CD26	11,15	CLA	CD26	6404	1803	Gene	Gene	lymphocytes|compound|START_ENTITY expression|nmod|lymphocytes expression|nummod|END_ENTITY	Absence of CD26 expression on skin-homing CLA + CD4 + T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with S __ zary_syndrome .
11564186	0	CLA	131,134	CD4	162,165	CLA	CD4	6404	920	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Development and characterization of a monoclonal antibody specific for fucosyltransferase_VII -LRB- Fuc-TVII -RRB- : discordant expression of CLA and Fuc-TVII in peripheral CD4 + and CD8 + T cells .
14705795	0	CLA	120,123	CD4	7,10	CLA	CD4	6404	920	Gene	Gene	cells|compound|START_ENTITY show|dobj|cells show|nsubj|cells cells|compound|END_ENTITY	Na ve CD4 + T cells from patients with atopic_dermatitis show an aberrant maturation towards IL-4-producing skin-homing CLA + cells .
15270870	0	CLA	35,38	CD4	30,33	CLA	CD4	6404	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Nickel-responding T cells are CD4 + CLA + CD45RO + and express chemokine receptors CXCR3 , CCR4 and CCR10 .
16197392	0	CLA	42,45	CD4	47,50	CLA	CD4	6404	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Absence of CD26 expression on skin-homing CLA + CD4 + T lymphocytes in peripheral blood is a highly sensitive marker for early diagnosis and therapeutic monitoring of patients with S __ zary_syndrome .
17222460	0	CLA	112,115	CD4	120,123	CLA	CD4	6404	920	Gene	Gene	antigen|appos|START_ENTITY constructs|nmod|antigen reactivity|nmod|constructs END_ENTITY|amod|reactivity	Varied levels of reactivity by different E-selectin/Fc constructs with cutaneous lymphocyte-associated antigen -LRB- CLA -RRB- -LRB- + -RRB- CD4 -LRB- + -RRB- T cells .
11703383	0	CLA	17,20	CD8	22,25	CLA	CD8	6404	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The frequency of CLA + CD8 + T cells in the blood of psoriasis patients correlates closely with the severity of their disease .
21198882	0	CLA	50,53	CD8	44,47	CLA	CD8	6404	925	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Reduction of skin-homing cytotoxic T cells -LRB- CD8 + - CLA + -RRB- in patients with vitiligo .
11401669	0	CLA	41,44	Cutaneous_lymphocyte-associated_antigen	0,39	CLA	Cutaneous lymphocyte-associated antigen	6404	6404	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cutaneous_lymphocyte-associated_antigen -LRB- CLA -RRB- expression in a lymphoblastoid_mantle_cell_lymphoma presenting with skin_lesions .
19665434	0	CLA	41,44	Cutaneous_lymphocyte-associated_antigen	0,39	CLA	Cutaneous lymphocyte-associated antigen	6404	6404	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Cutaneous_lymphocyte-associated_antigen -LRB- CLA -RRB- T cells up-regulate P-selectin ligand expression upon their activation .
16269612	0	CLA	35,38	E-selectin	21,31	CLA	E-selectin	6404	6401	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	CD43 is a ligand for E-selectin on CLA + human T cells .
9428573	0	CLA	69,72	cationic_leukocyte_antigen	41,67	CLA	cationic leukocyte antigen	6404	6404	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cellular and subcellular localization of cationic_leukocyte_antigen -LRB- CLA -RRB- in human eosinophil granulocytes .
15925831	0	CLA	55,58	cutaneous_lymphocyte-associated_antigen	14,53	CLA	cutaneous lymphocyte-associated antigen	6404	6404	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cutaneous_lymphocyte-associated_antigen -LRB- CLA -RRB- in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis_palmaris et plantaris -LRB- PPP -RRB- .
9865449	0	CLA	89,92	cutaneous_lymphocyte-associated_antigen	94,133	CLA	cutaneous lymphocyte-associated antigen	6404	6404	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Increased numbers of CD68 antigen positive dendritic epidermal cells and upregulation of CLA -LRB- cutaneous_lymphocyte-associated_antigen -RRB- expression on these cells in various skin_diseases .
7509795	1	CLA-1	163,168	CD36	138,142	CLA-1	CD36	949	948	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	Conservation of exon organization and pre-mRNA splicing patterns with a CD36 gene family member , CLA-1 .
15576377	0	CLA-1	27,32	CD36_and_LIMPII_analogous-1	34,61	CLA-1	CD36 and LIMPII analogous-1	949	949;948	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Serum amyloid A binding to CLA-1 -LRB- CD36_and_LIMPII_analogous-1 -RRB- mediates serum_amyloid_A_protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases .
9575181	0	CLARP	85,90	RICK	0,4	CLARP	RICK	8837	8767	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RICK , a novel protein kinase containing a caspase recruitment domain , interacts with CLARP and regulates CD95-mediated apoptosis .
23477787	0	CLASP	0,5	sorting_nexin_1	21,36	CLASP	sorting nexin 1	816539(Tax:3702)	830501(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CLASP interacts with sorting_nexin_1 to link microtubules and auxin transport via PIN2 recycling in Arabidopsis_thaliana .
19561070	0	CLASP1	21,27	PRC1	0,4	CLASP1	PRC1	23332	9055	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis .
19924516	0	CLASP2	20,26	FEZ1	0,4	CLASP2	FEZ1	23122	9638	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC .
19638411	0	CLASP2	19,25	IQGAP1	70,76	CLASP2	IQGAP1	23122	8826	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1 , EB1 and microtubules .
25326330	0	CLASPIN	54,61	CHK1	24,28	CLASPIN	CHK1	63967	1111	Gene	Gene	stability|compound|START_ENTITY modulating|dobj|stability coordinates|advcl|modulating coordinates|dobj|activation activation|compound|END_ENTITY	HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability .
12865300	0	CLB	117,120	Clb	80,83	CLB	Clb	171425	171425	Gene	Gene	activation|compound|START_ENTITY mechanism|nmod|activation Recruitment|dep|mechanism Recruitment|nmod|Ndd1p Ndd1p|nmod|domain domain|nmod|activity activity|compound|END_ENTITY	Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity : a mechanism for CLB cluster gene activation .
12865300	0	CLB	117,120	Fkh2p	65,70	CLB	Fkh2p	171425	2290	Gene	Gene	activation|compound|START_ENTITY mechanism|nmod|activation Recruitment|dep|mechanism Recruitment|nmod|Ndd1p Ndd1p|nmod|domain domain|nmod|activity activity|compound|END_ENTITY	Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity : a mechanism for CLB cluster gene activation .
10101018	0	CLC-2	38,43	Keratinocyte_growth_factor	0,26	CLC-2	Keratinocyte growth factor	29232(Tax:10116)	29348(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Keratinocyte_growth_factor stimulates CLC-2 expression in primary fetal rat distal lung epithelial cells .
18614997	0	CLC-K1	61,67	serum_and_glucocorticoid-inducible_kinase_1	73,116	CLC-K1	serum and glucocorticoid-inducible kinase 1	12733(Tax:10090)	20393(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	High osmolality induces the kidney-specific chloride channel CLC-K1 by a serum_and_glucocorticoid-inducible_kinase_1 MAPK pathway .
20875871	0	CLCA2	0,5	RUNX1	15,20	CLCA2	RUNX1	9635	861	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	CLCA2 , a novel RUNX1 partner gene in a therapy-related_leukemia with t -LRB- 1 ; 21 -RRB- -LRB- p22 ; q22 -RRB- .
21204798	0	CLCN1	79,84	CNBP	115,119	CLCN1	CNBP	1180	7555	Gene	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Myotonia_congenita and myotonic_dystrophy in the same family : coexistence of a CLCN1 mutation and expansion in the CNBP -LRB- ZNF9 -RRB- gene .
17156979	0	CLCN2	38,43	chloride_channel_2	18,36	CLCN2	chloride channel 2	1181	1181	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Quantification of chloride_channel_2 -LRB- CLCN2 -RRB- gene isoforms in normal versus lesion - and epilepsy-associated brain tissue .
20680351	0	CLCN5	8,13	growth_hormone	71,85	CLCN5	growth hormone	1184	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	A novel CLCN5 mutation in a boy with Bartter-like_syndrome and partial growth_hormone deficiency .
17213806	0	CLCP1	0,5	semaphorin_4B	21,34	CLCP1	semaphorin 4B	266626	10509	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CLCP1 interacts with semaphorin_4B and regulates motility of lung_cancer cells .
18816383	0	CLDN16	125,131	claudin_16	113,123	CLDN16	claudin 16	10686	10686	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Familial_hypomagnesaemia with hypercalciuria and nephrocalcinosis -LRB- FHHNC -RRB- : compound heterozygous mutation in the claudin_16 -LRB- CLDN16 -RRB- gene .
21102412	0	CLDN4	25,30	claudin-4	14,23	CLDN4	claudin-4	1364	1364	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of claudin-4 -LRB- CLDN4 -RRB- mRNA in intraductal_papillary_mucinous_neoplasms of the pancreas .
22235125	0	CLDN5	111,116	claudin_5	100,109	CLDN5	claudin 5	7122	7122	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	ETS-related_gene -LRB- ERG -RRB- controls endothelial cell permeability via transcriptional regulation of the claudin_5 -LRB- CLDN5 -RRB- gene .
19785988	0	CLEC-2	22,28	RACK1	0,5	CLEC-2	RACK1	56760(Tax:10090)	14694(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation .
20154219	0	CLEC-2	0,6	Syk	17,20	CLEC-2	Syk	51266	6850	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CLEC-2 activates Syk through dimerization .
21728173	0	CLEC-2	0,6	Syk	21,24	CLEC-2	Syk	56760(Tax:10090)	20963(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses .
25447402	0	CLEC16A	57,64	C-type_lectin-like_domain_family-16A	19,55	CLEC16A	C-type lectin-like domain family-16A	23274	23274	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the C-type_lectin-like_domain_family-16A -LRB- CLEC16A -RRB- gene polymorphisms with acute_coronary_syndrome in Mexican patients .
22234694	0	CLEC9A	27,33	BDCA3	98,103	CLEC9A	BDCA3	283420	7056	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|cells cells|compound|END_ENTITY	The C-type_lectin_receptor CLEC9A mediates antigen uptake and -LRB- cross - -RRB- presentation by human blood BDCA3 + myeloid dendritic cells .
7607691	0	CLG3	25,29	collagenase-3	10,23	CLG3	collagenase-3	4322	4322	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human collagenase-3 -LRB- CLG3 -RRB- gene is located on chromosome 11q22 .3 clustered to other members of the matrix metalloproteinase gene family .
25546839	0	CLIC1	78,83	chloride_intracellular_channel_1_and_4	38,76	CLIC1	chloride intracellular channel 1 and 4	1192	1192;25932	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Chloride channels in cancer : Focus on chloride_intracellular_channel_1_and_4 -LRB- CLIC1 AND CLIC4 -RRB- proteins in tumor development and as novel therapeutic targets .
14569596	0	CLIC4	0,5	AKAP350	62,69	CLIC4	AKAP350	25932	10142	Gene	Gene	enriched|nsubjpass|START_ENTITY enriched|nmod|END_ENTITY	CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells .
24886590	0	CLIC4	90,95	chloride_intracellular_channel_4	56,88	CLIC4	chloride intracellular channel 4	29876(Tax:10090)	29876(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Detection of differential fetal and adult expression of chloride_intracellular_channel_4 -LRB- CLIC4 -RRB- protein by analysis of a green fluorescent protein knock-in mouse line .
23047949	0	CLIMP-63	62,70	Dicer	20,25	CLIMP-63	Dicer	10970	23405	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human Dicer by the resident ER membrane protein CLIMP-63 .
21116212	0	CLINT1	35,41	Epsin_4	43,50	CLINT1	Epsin 4	9685	9685	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Association study of the GRIA1 and CLINT1 -LRB- Epsin_4 -RRB- genes in a German schizophrenia sample .
9300699	0	CLIP	66,70	class_II-associated_Ii_peptide	34,64	CLIP	class II-associated Ii peptide	6249	6249	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Identification of residues in the class_II-associated_Ii_peptide -LRB- CLIP -RRB- region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner .
10837403	0	CLIP	68,72	class_II-associated_invariant_chain_peptide	23,66	CLIP	class II-associated invariant chain peptide	6249	6249	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The functional role of class_II-associated_invariant_chain_peptide -LRB- CLIP -RRB- in its ability to variably modulate immune responses .
1849784	0	CLIP	82,86	corticotropin-like_intermediate_lobe_peptide	36,80	CLIP	corticotropin-like intermediate lobe peptide	5443	5443	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Immunohistochemical distribution of corticotropin-like_intermediate_lobe_peptide -LRB- CLIP -RRB- immunoreactivity in the human brain .
24777477	0	CLIP-170	0,8	PLK1	18,22	CLIP-170	PLK1	6249	5347	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	CLIP-170 recruits PLK1 to kinetochores during early mitosis for chromosome alignment .
24451569	0	CLIP-170	20,28	Plk1	0,4	CLIP-170	Plk1	6249	5347	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Plk1 phosphorylates CLIP-170 and regulates its binding to microtubules for chromosome alignment .
16889924	0	CLK-1	42,47	mCLK1	48,53	CLK-1	mCLK1	175729(Tax:6239)	12747(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Genetic and molecular characterization of CLK-1 / mCLK1 , a conserved determinant of the rate of aging .
19194796	0	CLK1	91,95	CDC-2-like_kinase_1	70,89	CLK1	CDC-2-like kinase 1	100141471(Tax:9823)	100141471(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning , expression , and chromosomal mapping of the porcine CDC-2-like_kinase_1 -LRB- CLK1 -RRB- gene .
1832336	0	CLN1	30,34	CLN2	36,40	CLN1	CLN2	855239(Tax:4932)	855819(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Transcriptional activation of CLN1 , _ CLN2 , and a putative new G1 cyclin -LRB- HCS26 -RRB- by SWI4 , a positive regulator of G1-specific transcription .
11001812	0	CLN1	78,82	CLN3	128,132	CLN1	CLN3	5538	1201	Gene	Gene	expression|nmod|START_ENTITY expression|dep|implications implications|nmod|END_ENTITY	Neural and extraneural expression of the neuronal_ceroid_lipofuscinoses genes CLN1 , _ CLN2 , and CLN3 : functional implications for CLN3 .
1832336	0	CLN2	36,40	CLN1	30,34	CLN2	CLN1	855819(Tax:4932)	855239(Tax:4932)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of CLN1 , _ CLN2 , and a putative new G1 cyclin -LRB- HCS26 -RRB- by SWI4 , a positive regulator of G1-specific transcription .
20977549	0	CLN2	40,44	Ssd1p	25,30	CLN2	Ssd1p	855819(Tax:4932)	851887(Tax:4932)	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Saccharomyces_cerevisiae Ssd1p promotes CLN2 expression by binding to the 5 ' - untranslated region of CLN2 mRNA .
8007977	0	CLN2	41,45	Swi4	8,12	CLN2	Swi4	855819(Tax:4932)	856847(Tax:4932)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression Role|nmod|regulation Role|nmod|END_ENTITY	Role of Swi4 in cell cycle regulation of CLN2 expression .
11001812	0	CLN3	128,132	CLN1	78,82	CLN3	CLN1	1201	5538	Gene	Gene	implications|nmod|START_ENTITY expression|dep|implications expression|nmod|END_ENTITY	Neural and extraneural expression of the neuronal_ceroid_lipofuscinoses genes CLN1 , _ CLN2 , and CLN3 : functional implications for CLN3 .
20850431	0	CLN3	23,27	Cln3	86,90	CLN3	Cln3	12752(Tax:10090)	12752(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|motility motility|nmod|cells cells|amod|END_ENTITY	A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3 -LRB- - / - -RRB- cells .
20850431	0	CLN3	23,27	myosin-IIB	43,53	CLN3	myosin-IIB	12752(Tax:10090)	77579(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3 -LRB- - / - -RRB- cells .
22431521	0	CLN5	54,58	ceroid_lipofuscinosis_neuronal_protein_5	12,52	CLN5	ceroid lipofuscinosis neuronal protein 5	1203	1203	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of ceroid_lipofuscinosis_neuronal_protein_5 -LRB- CLN5 -RRB- in endosomal sorting .
15828232	0	CLOCK	107,112	BMAL1	114,119	CLOCK	BMAL1	9575	406	Gene	Gene	gene|nmod|START_ENTITY regulation|nmod|gene Hyperlipidemia|dep|regulation Hyperlipidemia|dep|END_ENTITY	-LSB- Hyperlipidemia and peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- -- regulation of the PPARalpha gene by CLOCK : BMAL1 -RSB- .
16628007	0	CLOCK	59,64	BMAL1	72,77	CLOCK	BMAL1	9575	406	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|complex complex|nummod|END_ENTITY	Post-translational regulation of circadian transcriptional CLOCK -LRB- NPAS2 -RRB- / BMAL1 complex by CRYPTOCHROMES .
23580255	0	CLOCK	95,100	BMAL1	101,106	CLOCK	BMAL1	9575	11865(Tax:10090)	Gene	Gene	DNA-binding|nmod|START_ENTITY nature|nmod|DNA-binding nature|dep|complex complex|nummod|END_ENTITY	Usf1 , a suppressor of the circadian Clock mutant , reveals the nature of the DNA-binding of the CLOCK : BMAL1 complex in mice .
24395244	0	CLOCK	0,5	BMAL1	6,11	CLOCK	BMAL1	9575	406	Gene	Gene	START_ENTITY|parataxis|factor factor|nsubj|END_ENTITY	CLOCK : BMAL1 is a pioneer-like transcription factor .
25228643	0	CLOCK	14,19	BMAL1	20,25	CLOCK	BMAL1	9575	406	Gene	Gene	modes|nmod|START_ENTITY modes|dep|inhibition inhibition|nummod|END_ENTITY	Dual modes of CLOCK : BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock .
20430893	0	CLOCK	0,5	Gys2	102,106	CLOCK	Gys2	9575	2998	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2 .
20861012	0	CLOCK	83,88	ID2	30,33	CLOCK	ID2	12753(Tax:10090)	15902(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression .
20956306	0	CLOCK	0,5	MyoD	25,29	CLOCK	MyoD	12753(Tax:10090)	17927(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function .
15828232	0	CLOCK	107,112	PPARalpha	89,98	CLOCK	PPARalpha	9575	5465	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	-LSB- Hyperlipidemia and peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- -- regulation of the PPARalpha gene by CLOCK : BMAL1 -RSB- .
27035655	0	CLOCK	0,5	SIRT1	56,61	CLOCK	SIRT1	12753(Tax:10090)	93759(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|sensitivity sensitivity|nmod|END_ENTITY	CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice .
26458764	0	CLOCK	10,15	Transforming_Growth_Factor-b	39,67	CLOCK	Transforming Growth Factor-b	12753(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|dobj|Activation Activation|nmod|Signaling Signaling|compound|END_ENTITY	Circadian CLOCK Mediates Activation of Transforming_Growth_Factor-b Signaling and Renal Fibrosis through Cyclooxygenase_2 .
23399917	0	CLOCK	41,46	cholecystokinin	22,37	CLOCK	cholecystokinin	12753(Tax:10090)	12424(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	An important role for cholecystokinin , a CLOCK target gene , in the development and treatment of manic-like behaviors .
19224106	0	CLOCK	33,38	clock	21,26	CLOCK	clock	9575	9575	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association study of clock gene -LRB- CLOCK -RRB- and schizophrenia and mood_disorders in the Japanese population .
19141540	0	CLOCK	38,43	glucocorticoid_receptor	90,113	CLOCK	glucocorticoid receptor	9575	2908	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid_receptor by acetylating its hinge region lysine cluster : potential physiological implications .
21980503	0	CLOCK	11,16	glucocorticoid_receptor	41,64	CLOCK	glucocorticoid receptor	9575	2908	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Peripheral CLOCK regulates target-tissue glucocorticoid_receptor transcriptional activity in a circadian fashion in man .
12387815	0	CLOCK	11,16	mPer2	126,131	CLOCK	mPer2	12753(Tax:10090)	18627(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|background background|amod|entrainment entrainment|nmod|clocks clocks|nmod|feeding feeding|dep|expression expression|nmod|mRNAs mRNAs|compound|END_ENTITY	Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding : entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl : ICR background .
25684245	0	CLOCK	41,46	miR-182	12,19	CLOCK	miR-182	60447(Tax:10116)	100314172(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of miR-182 in regulating pineal CLOCK expression after hypoxia-ischemia brain injury in neonatal rats .
15500444	0	CLOCK	0,5	peroxisome-proliferator-activated_receptor_alpha	54,102	CLOCK	peroxisome-proliferator-activated receptor alpha	12753(Tax:10090)	19013(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|transactivation transactivation|nmod|END_ENTITY	CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in mice .
20930143	0	CLOCK-BMAL1	20,31	CBP	43,46	CLOCK-BMAL1	CBP	9575;406	1387	Gene	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock .
19166543	0	CLP	31,34	calmodulin-like_protein	6,29	CLP	calmodulin-like protein	810	810	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human calmodulin-like_protein -LRB- CLP -RRB- expression in oral squamous mucosa and in malignant transformation .
20940258	0	CLP-1	0,5	MyoD	22,26	CLP-1	MyoD	98985(Tax:10090)	17927(Tax:10090)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration .
18624753	0	CLP-1	44,49	cardiac_lineage_protein	19,42	CLP-1	cardiac lineage protein	98985(Tax:10090)	98985(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Down-regulation of cardiac_lineage_protein -LRB- CLP-1 -RRB- expression in CLP-1 + / - mice affords .
3301539	0	CLS4	27,31	CDC24	33,38	CLS4	CDC24	851190(Tax:4932)	851190(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Nucleotide sequence of the CLS4 -LRB- CDC24 -RRB- gene of Saccharomyces_cerevisiae .
11485898	0	CLTC	57,61	clathrin_heavy_chain	30,50	CLTC	clathrin heavy chain	1213	1213	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fusion of the ALK gene to the clathrin_heavy_chain gene , CLTC , in inflammatory_myofibroblastic_tumor .
12920229	0	CLTC	121,125	clathrin_heavy_chain	94,114	CLTC	clathrin heavy chain	1213	1213	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	ALK + , CD30 - , CD20 - large B-cell_lymphoma containing anaplastic_lymphoma kinase -LRB- ALK -RRB- fused to clathrin_heavy_chain gene -LRB- CLTC -RRB- .
24491388	0	CLU	37,40	Twist1	60,66	CLU	Twist1	12759(Tax:10090)	22160(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Insulin-like growth factor-I induces CLU expression through Twist1 to promote prostate_cancer growth .
19879421	0	CLU	23,26	clusterin	12,21	CLU	clusterin	1191	1191	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of clusterin -LRB- CLU -RRB- in malignant transformation and drug resistance in breast_carcinomas .
16446531	0	CMA1	14,18	Chymase	0,7	CMA1	Chymase	1215	1215	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chymase gene -LRB- CMA1 -RRB- polymorphisms in Dutch and Japanese sarcoidosis patients .
8468056	0	CMA1	34,38	chymase	20,27	CMA1	chymase	1215	1215	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human mast cell chymase gene -LRB- CMA1 -RRB- : mapping to the cathepsin_G / granzyme gene cluster and lineage-restricted expression .
22042284	0	CMG2	40,44	ANTXR2	32,38	CMG2	ANTXR2	118429	118429	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel splice site mutation in ANTXR2 -LRB- CMG2 -RRB- gene results in systemic_hyalinosis .
22118966	0	CMKLR1	35,41	Adiponectin	0,11	CMKLR1	Adiponectin	1240	9370	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty_liver .
26363224	0	CMKLR1	0,6	Chemerin	24,32	CMKLR1	Chemerin	1240	5919	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	CMKLR1 and GPR1 Mediate Chemerin Signaling Through the RhoA/ROCK Pathway .
22186410	0	CMKLR1	45,51	chemokine-like_receptor-1	18,43	CMKLR1	chemokine-like receptor-1	14747(Tax:10090)	14747(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disruption of the chemokine-like_receptor-1 -LRB- CMKLR1 -RRB- gene is associated with reduced adiposity and glucose_intolerance .
9284939	0	CMOAT	76,81	canalicular_multispecific_organic_anion_transporter	18,69	CMOAT	canalicular multispecific organic anion transporter	1244	25303(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the canalicular_multispecific_organic_anion_transporter gene -LRB- CMOAT -RRB- to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization .
8590734	5	CMS5	733,737	B7-1	727,731	CMS5	B7-1	8292	941	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	We found that neither B7-1 + nor IL-2-secreting , _ B7-1 + CMS5 cells stimulated naive spleen cells to proliferate or to become cytotoxic .
24011642	0	CMT4F	65,70	periaxin	45,53	CMT4F	periaxin	57716	57716	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	-LSB- Charcot-Marie-Tooth_disease associated with periaxin mutations -LRB- CMT4F -RRB- : Clinical , electrophysiological and genetic analysis of 24 patients -RSB- .
21034562	0	CMTM2	14,19	AP-1	135,139	CMTM2	AP-1	146225	3725	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	Intracellular CMTM2 negatively regulates human_immunodeficiency_virus_type-1 transcription through targeting the transcription factors AP-1 and CREB .
21168207	0	CMTM5	64,69	CKLF-like_MARVEL_transmembrane_member_5	23,62	CMTM5	CKLF-like MARVEL transmembrane member 5	116173	116173	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Aberrant expression of CKLF-like_MARVEL_transmembrane_member_5 -LRB- CMTM5 -RRB- by promoter methylation in myeloid_leukemia .
23893243	0	CMTM7	20,25	EGFR	46,50	CMTM7	EGFR	112616	1956	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	A novel 3p22 .3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth .
23778016	0	CMYA5	43,48	cardiomyopathy-associated_5	50,77	CMYA5	cardiomyopathy-associated 5	202333	202333	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Genetic analysis of common variants in the CMYA5 -LRB- cardiomyopathy-associated_5 -RRB- gene with schizophrenia .
24172884	0	CMYC	28,32	Androgen_receptor	0,17	CMYC	Androgen receptor	4609	367	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Androgen_receptor decreases CMYC and KRAS expression by upregulating let-7a expression in ER - , PR - , AR + breast_cancer .
21204798	0	CNBP	115,119	CLCN1	79,84	CNBP	CLCN1	7555	1180	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|compound|END_ENTITY	Myotonia_congenita and myotonic_dystrophy in the same family : coexistence of a CLCN1 mutation and expansion in the CNBP -LRB- ZNF9 -RRB- gene .
21204798	0	CNBP	115,119	ZNF9	121,125	CNBP	ZNF9	7555	7555	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Myotonia_congenita and myotonic_dystrophy in the same family : coexistence of a CLCN1 mutation and expansion in the CNBP -LRB- ZNF9 -RRB- gene .
10519652	0	CNF	30,33	phospholipase_A2	37,53	CNF	phospholipase A2	4868	151056	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Studies on the specificity of CNF , a phospholipase_A2 inhibitor isolated from the blood plasma of the South American rattlesnake -LRB- Crotalus durissus terrificus -RRB- .
26567794	0	CNGB3	90,95	Ciliary_Neurotrophic_Factor	13,40	CNGB3	Ciliary Neurotrophic Factor	30952(Tax:10090)	12803(Tax:10090)	Gene	Gene	Function|nmod|START_ENTITY Function|compound|END_ENTITY	Intravitreal Ciliary_Neurotrophic_Factor Transiently Improves Cone-Mediated Function in a CNGB3 - / - Mouse Model of Achromatopsia .
24405750	0	CNIH4	0,5	GPCR	39,43	CNIH4	GPCR	29097	441931	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum .
14517245	0	CNK	29,32	RAF	22,25	CNK	RAF	36952(Tax:7227)	31221(Tax:7227)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bimodal regulation of RAF by CNK in Drosophila .
24825906	0	CNK1	24,28	EphrinB1	0,8	CNK1	EphrinB1	10256	1947	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation .
22962429	0	CNP	28,31	C-Type_Natriuretic_Peptide	0,26	CNP	C-Type Natriuretic Peptide	4880	4880	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	C-Type_Natriuretic_Peptide -LRB- CNP -RRB- levels are altered in boys with Klinefelter_syndrome .
8117275	0	CNP	91,94	C-type_natriuretic_peptide	13,39	CNP	C-type natriuretic peptide	4880	4880	Gene	Gene	START_ENTITY|nsubj|Detection Detection|nmod|END_ENTITY	Detection of C-type_natriuretic_peptide in human circulation and marked increase of plasma CNP level in septic_shock patients .
9089468	0	CNP	41,44	C-type_natriuretic_peptide	13,39	CNP	C-type natriuretic peptide	4880	4880	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of C-type_natriuretic_peptide -LRB- CNP -RRB- by immortalized LHRH cells .
7698765	0	CNP	130,133	NPPC	140,144	CNP	NPPC	12799(Tax:10090)	4880	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and chromosomal assignment of the mouse C-type_natriuretic_peptide _ -LRB- CNP -RRB- gene -LRB- Nppc -RRB- : comparison with the human CNP gene -LRB- NPPC -RRB- .
2383278	0	CNP-53	58,64	C-type_natriuretic_peptide	30,56	CNP-53	C-type natriuretic peptide	4880	4880	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	N-terminally extended form of C-type_natriuretic_peptide -LRB- CNP-53 -RRB- identified in porcine brain .
11841893	0	CNR1	48,52	CB1	17,20	CNR1	CB1	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of a CB1 cannabinoid receptor gene -LRB- CNR1 -RRB- polymorphism with severe alcohol_dependence .
21633404	0	CNR1	51,55	CB1	41,44	CNR1	CB1	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variants at the endocannabinoid receptor CB1 gene -LRB- CNR1 -RRB- and insulin sensitivity , type_2_diabetes , and coronary_heart_disease .
21129839	0	CNR1	50,54	cannabinoid_1_receptor	26,48	CNR1	cannabinoid 1 receptor	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common variation in the cannabinoid_1_receptor -LRB- CNR1 -RRB- gene is associated with pre-eclampsia in the Central European population .
10441206	0	CNR1	78,82	cannabinoid_receptor	56,76	CNR1	cannabinoid receptor	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A frequent polymorphism in the coding exon of the human cannabinoid_receptor -LRB- CNR1 -RRB- gene .
19420965	0	CNR1	56,60	cannabinoid_receptor-1	32,54	CNR1	cannabinoid receptor-1	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide change in the cannabinoid_receptor-1 -LRB- CNR1 -RRB- gene in colorectal_cancer outcome .
19443135	0	CNR1	53,57	cannabinoid_receptor_1	24,46	CNR1	cannabinoid receptor 1	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association between cannabinoid_receptor_1 gene -LRB- CNR1 -RRB- and cannabis_dependence symptoms in adolescents and young adults .
19725030	0	CNR1	54,58	cannabinoid_receptor_1	25,47	CNR1	cannabinoid receptor 1	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter variants of the cannabinoid_receptor_1 gene -LRB- CNR1 -RRB- in interaction with 5-HTTLPR affect the anxious phenotype .
20107430	0	CNR1	53,57	cannabinoid_receptor_1	29,51	CNR1	cannabinoid receptor 1	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common polymorphism in the cannabinoid_receptor_1 -LRB- CNR1 -RRB- gene is associated with antipsychotic-induced weight_gain in Schizophrenia .
21266946	0	CNR1	45,49	cannabinoid_receptor_1	21,43	CNR1	cannabinoid receptor 1	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of cannabinoid_receptor_1 -LRB- CNR1 -RRB- gene in tardive_dyskinesia .
12082570	0	CNR1	0,4	central_cannabinoid_receptor	6,34	CNR1	central cannabinoid receptor	1268	1268	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	CNR1 , central_cannabinoid_receptor gene , associated with susceptibility to hebephrenic_schizophrenia .
15108190	0	CNR1	82,86	central_cannabinoid_receptor	52,80	CNR1	central cannabinoid receptor	1268	1268	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Tourette_syndrome is not caused by mutations in the central_cannabinoid_receptor -LRB- CNR1 -RRB- gene .
17508995	0	CNR1	94,98	dopamine_D4_receptor	21,41	CNR1	dopamine D4 receptor	1268	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of the dopamine_D4_receptor gene -LRB- DRD4 VNTR -RRB- and cannabinoid CB1 receptor gene -LRB- CNR1 -RRB- are not strongly related to cue-reactivity after alcohol exposure .
19496827	0	CNR2	47,51	cannabinoid_receptor_2	23,45	CNR2	cannabinoid receptor 2	1269	1269	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Species differences in cannabinoid_receptor_2 -LRB- CNR2 gene -RRB- : identification of novel human and rodent CB2 isoforms , differential tissue expression and regulation by cannabinoid receptor ligands .
19565271	0	CNR2	33,37	cannabinoid_receptor_type_2	4,31	CNR2	cannabinoid receptor type 2	1269	1269	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The cannabinoid_receptor_type_2 -LRB- CNR2 -RRB- gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample .
25092804	0	CNTF	29,33	Ciliary_neurotrophic_factor	0,27	CNTF	Ciliary neurotrophic factor	1270	1270	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance .
9051264	0	CNTF	0,4	GFAP	13,17	CNTF	GFAP	25707(Tax:10116)	24387(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	CNTF induces GFAP in a S-100 alpha brain cell population : the pattern of CNTF-alpha R suggests an indirect mode of action .
11303750	0	CNTF	18,22	IL-6	0,4	CNTF	IL-6	25707(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-6 up-regulates CNTF mRNA expression and enhances neurite regeneration .
8025241	0	CNTF	0,4	NGF	20,23	CNTF	NGF	25707(Tax:10116)	310738(Tax:10116)	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|END_ENTITY	CNTF is superior to NGF as a survival enhancement factor for adrenal medulla cells in vitro .
1666130	0	CNTF	10,14	NGF_receptor	31,43	CNTF	NGF receptor	25707(Tax:10116)	24596(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of CNTF on low-affinity NGF_receptor expression by cultured neurons from different rat brain regions .
10660304	0	CNTF	62,66	STAT3	49,54	CNTF	STAT3	1270	6774	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR .
9379846	0	CNTF	0,4	TIMP-2	22,28	CNTF	TIMP-2	1270	7077	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	CNTF up-regulation of TIMP-2 in neuroblastoma cells .
10623441	0	CNTF	40,44	ciliary_neurotrophic_factor	11,38	CNTF	ciliary neurotrophic factor	25707(Tax:10116)	25707(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of ciliary_neurotrophic_factor -LRB- CNTF -RRB- on protein turnover in cultured muscle cells .
10860786	0	CNTF	63,67	ciliary_neurotrophic_factor	34,61	CNTF	ciliary neurotrophic factor	25707(Tax:10116)	25707(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Adenovirus-mediated expression of ciliary_neurotrophic_factor -LRB- CNTF -RRB- rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo .
11299332	0	CNTF	119,123	ciliary_neurotrophic_factor	90,117	CNTF	ciliary neurotrophic factor	12803(Tax:10090)	12803(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of Ras extracellular-signal-regulated_kinase -LRB- ERK -RRB- mediated signaling promotes ciliary_neurotrophic_factor -LRB- CNTF -RRB- expression in Schwann cells .
8759781	0	CNTF	60,64	ciliary_neurotrophic_factor	31,58	CNTF	ciliary neurotrophic factor	1270	1270	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and expression of ciliary_neurotrophic_factor -LRB- CNTF -RRB- in postmortem sciatic nerve from patients with motor_neuron_disease and diabetic_neuropathy .
9202298	0	CNTF	66,70	ciliary_neurotrophic_factor	37,64	CNTF	ciliary neurotrophic factor	25707(Tax:10116)	25707(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Construction and characterization of ciliary_neurotrophic_factor -LRB- CNTF -RRB- antagonists : microenvironmental difference in the CNTF receptor between rat and chicken cells for recognizing the D1 cap region .
9247976	0	CNTF	51,55	ciliary_neurotrophic_factor	22,49	CNTF	ciliary neurotrophic factor	1270	1270	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Schizophrenia and the ciliary_neurotrophic_factor -LRB- CNTF -RRB- gene : no evidence for association .
9363597	0	CNTF	101,105	ciliary_neurotrophic_factor	72,99	CNTF	ciliary neurotrophic factor	1270	12803(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation , characterization and chromosomal localization of the porcine ciliary_neurotrophic_factor -LRB- CNTF -RRB- gene .
9628240	0	CNTF	62,66	ciliary_neurotrophic_factor	33,60	CNTF	ciliary neurotrophic factor	1270	1270	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Screening for variability in the ciliary_neurotrophic_factor -LRB- CNTF -RRB- gene : no evidence for association with human obesity .
15106122	0	CNTN4	27,32	contactin_4	14,25	CNTN4	contactin 4	152330	152330	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Disruption of contactin_4 -LRB- CNTN4 -RRB- results in developmental_delay and other features of 3p deletion syndrome .
11352571	0	CNTNAP2	52,59	contactin-associated_protein-like_2	10,45	CNTNAP2	contactin-associated protein-like 2	26047	26047	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human contactin-associated_protein-like_2 gene -LRB- CNTNAP2 -RRB- spans over 2 Mb of DNA at chromosome 7q35 .
25883416	0	CNTNAP3	0,7	ATG16L1	19,26	CNTNAP3	ATG16L1	79937	55054	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	CNTNAP3 Associated ATG16L1 Expression and Crohn 's _ Disease .
2106256	0	CO2	20,23	C-1	47,50	CO2	C-1	717	3183	Gene	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Recovery of labeled CO2 during the infusion of C-1 - vs C-2-labeled_acetate : implications for tracer studies of substrate oxidation .
26636511	0	CO2	21,24	CO2	36,39	CO2	CO2	717	717	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of end tidal CO2 and venous CO2 levels on postoperative_nausea_and_vomiting in paediatric patients .
26636511	0	CO2	36,39	CO2	21,24	CO2	CO2	717	717	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of end tidal CO2 and venous CO2 levels on postoperative_nausea_and_vomiting in paediatric patients .
2972894	0	CO2	26,29	CO2	43,46	CO2	CO2	717	717	Gene	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	Changes of transcutaneous CO2 and arterial CO2 tension during laparoscopy .
2972894	0	CO2	43,46	CO2	26,29	CO2	CO2	717	717	Gene	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes of transcutaneous CO2 and arterial CO2 tension during laparoscopy .
15798904	0	CO2	50,53	Cx26	18,22	CO2	Cx26	717	2706	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Opposite Cx32 and Cx26 voltage-gating response to CO2 reflects opposite voltage-gating polarity .
19673568	0	CO2	64,67	H2_and_D2	10,19	CO2	H2 and D2	717	6019;28503	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Ultrafast H2_and_D2 rotational Raman responses in near critical CO2 : an experimental and theoretical study of anisotropic solvation dynamics .
10542985	0	CO2	15,18	carbonic_anhydrase_II	36,57	CO2	carbonic anhydrase II	717	760	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Elimination of CO2 in patients with carbonic_anhydrase_II deficiency , with studies of respiratory function at rest .
2111014	0	CO2	21,24	carbonic_anhydrase_II	53,74	CO2	carbonic anhydrase II	717	760	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of substrate CO2 to the active site of human carbonic_anhydrase_II : a molecular dynamics study .
3126084	0	CO2	38,41	carbonic_anhydrase_II	70,91	CO2	carbonic anhydrase II	717	760	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Histidine 64 is not required for high CO2 hydration activity of human carbonic_anhydrase_II .
3126803	0	CO2	84,87	carbonic_anhydrase_II	143,164	CO2	carbonic anhydrase II	717	760	Gene	Gene	hydration|compound|START_ENTITY ion|nmod|hydration interaction|nmod|ion basis|dep|interaction basis|dep|reactions reactions|acl|catalyzed catalyzed|nmod|END_ENTITY	Molecular basis of ionic strength effects : interaction of enzyme and sulfate ion in CO2 hydration and HCO3 - dehydration reactions catalyzed by carbonic_anhydrase_II .
6433979	0	CO2	20,23	carbonic_anhydrase_II	53,74	CO2	carbonic anhydrase II	717	760	Gene	Gene	hydration|compound|START_ENTITY inhibition|nmod|hydration catalyzed|nsubj|inhibition catalyzed|nmod|END_ENTITY	Anion inhibition of CO2 hydration catalyzed by human carbonic_anhydrase_II .
24220509	0	CO2	0,3	connexin_26	23,34	CO2	connexin 26	717	2706	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	CO2 directly modulates connexin_26 by formation of carbamate bridges between subunits .
20181940	0	CO2	9,12	interleukin-6	34,47	CO2	interleukin-6	717	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Elevated CO2 selectively inhibits interleukin-6 and tumor_necrosis_factor expression and decreases phagocytosis in the macrophage .
12802648	0	CO2	0,3	plasminogen_activator_inhibitor_type_1	13,51	CO2	plasminogen activator inhibitor type 1	717	5054	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	CO2 promotes plasminogen_activator_inhibitor_type_1 expression in human mesothelial cells .
15530430	0	COBRA1	0,6	AP-1	16,20	COBRA1	AP-1	25920	3725	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	COBRA1 inhibits AP-1 transcriptional activity in transfected cells .
17043641	0	COBRA1	62,68	cofactor_of_BRCA1	43,60	COBRA1	cofactor of BRCA1	25920	25920	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of clustered gene expression by cofactor_of_BRCA1 -LRB- COBRA1 -RRB- in breast_cancer cells .
10891988	0	COCH	63,67	DFNA9	78,83	COCH	DFNA9	1690	1690	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Familial progressive vestibulocochlear_dysfunction caused by a COCH mutation -LRB- DFNA9 -RRB- .
16151338	0	COCH	68,72	DFNA9	83,88	COCH	DFNA9	1690	1690	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Vestibular_deterioration precedes hearing_deterioration in the P51S COCH mutation -LRB- DFNA9 -RRB- : an analysis in 74 mutation carriers .
27023102	0	COCH	53,57	DFNA9	68,73	COCH	DFNA9	1690	1690	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	Histopathology of the Human Inner Ear in the p.L114P COCH Mutation -LRB- DFNA9 -RRB- .
19533689	0	COH1	25,29	VPS13B	17,23	COH1	VPS13B	157680	157680	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Deletions in the VPS13B -LRB- COH1 -RRB- gene as a cause of Cohen_syndrome .
21637466	0	COI	177,180	Cytochrome_c_Oxidase_subunit_I	145,175	COI	Cytochrome c Oxidase subunit I	4512	4512	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Population structure of the Monocelis lineata -LRB- Proseriata , Monocelididae -RRB- species complex assessed by phylogenetic analysis of the mitochondrial Cytochrome_c_Oxidase_subunit_I -LRB- COI -RRB- gene .
19674236	0	COI	49,52	cytochrome_C_oxidase_subunit_I	17,47	COI	cytochrome C oxidase subunit I	248139	19893533	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequences of the cytochrome_C_oxidase_subunit_I -LRB- COI -RRB- gene are suitable for species identification of Korean Calliphorinae flies of forensic importance -LRB- Diptera : Calliphoridae -RRB- .
18685863	0	COI	34,37	cytochrome_c-oxidase	12,32	COI	cytochrome c-oxidase	172832(Tax:6239)	172832(Tax:6239)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of cytochrome_c-oxidase -LRB- COI -RRB- gene of mitochondrial DNA from the Trichinella spp .
16147869	0	COI	76,79	cytochrome_c_oxidase_subunit_I	44,74	COI	cytochrome c oxidase subunit I	19893533	19893533	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evolutionary and structural analysis of the cytochrome_c_oxidase_subunit_I -LRB- COI -RRB- gene from Haematobia irritans , Stomoxys calcitrans and Musca domestica -LRB- Diptera : Muscidae -RRB- mitochondrial DNA .
20654571	0	COI	115,118	cytochrome_c_oxidase_subunit_I	83,113	COI	cytochrome c oxidase subunit I	8250942(Tax:334426)	8250942(Tax:334426)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular differentiation of Angiostrongylus taxa -LRB- Nematoda : Angiostrongylidae -RRB- by cytochrome_c_oxidase_subunit_I -LRB- COI -RRB- gene sequences .
22232919	0	COI	172,175	cytochrome_oxidase_I	145,165	COI	cytochrome oxidase I	4512	4512	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Molecular phylogeny and the time of divergence of minges -LRB- Chironomidae , Nematocera , Diptera -RRB- inferred from a partial nucleotide sequence of the cytochrome_oxidase_I gene -LRB- COI -RRB- -RSB- .
20127754	0	COII	67,71	cytochrome_oxidase_subunit_II	36,65	COII	cytochrome oxidase subunit II	10964132	10964132	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of two haplotypes of cytochrome_oxidase_subunit_II -LRB- COII -RRB- gene of the Formosan_subterranean_termite , Coptotermes_formosanus Shiraki -LRB- Isoptera : Rhinotermitidae -RRB- , in southern Mississippi .
21527992	0	COL11A1	65,72	COL18A1	74,81	COL11A1	COL18A1	1301	80781	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	A DNA pooling-based case-control study of myopia candidate genes COL11A1 , COL18A1 , FBN1 , and PLOD1 in a Chinese population .
21527992	0	COL11A1	65,72	FBN1	83,87	COL11A1	FBN1	1301	2200	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	A DNA pooling-based case-control study of myopia candidate genes COL11A1 , COL18A1 , FBN1 , and PLOD1 in a Chinese population .
21527992	0	COL18A1	74,81	COL11A1	65,72	COL18A1	COL11A1	80781	1301	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	A DNA pooling-based case-control study of myopia candidate genes COL11A1 , COL18A1 , FBN1 , and PLOD1 in a Chinese population .
21527992	0	COL18A1	74,81	FBN1	83,87	COL18A1	FBN1	80781	2200	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	A DNA pooling-based case-control study of myopia candidate genes COL11A1 , COL18A1 , FBN1 , and PLOD1 in a Chinese population .
25502582	0	COL1A1	39,45	Collagen	29,37	COL1A1	Collagen	1277	1277	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	The Polymorphism of Type 1 Collagen -LRB- COL1A1 -RRB- Gene does not Correlate with an Increased Risk of Foot Ulcers in Patients with Diabetes_Mellitus .
26727275	0	COL1A1	4,10	SP1	11,14	COL1A1	SP1	1277	6667	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic_acid .
10550452	0	COL1A1	39,45	Sp1	19,22	COL1A1	Sp1	1277	6667	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Polymorphism at an Sp1 binding site of COL1A1 and bone_mineral_density in premenopausal female twins and elderly fracture patients .
11522109	0	COL1A1	58,64	Sp1	29,32	COL1A1	Sp1	1277	6667	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|nsubj|method method|nmod|site site|amod|END_ENTITY	New PCR-based method for the Sp1 site polymorphism in the COL1A1 gene .
11547832	0	COL1A1	0,6	Sp1	7,10	COL1A1	Sp1	1277	6667	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone_loss .
14613485	0	COL1A1	35,41	Sp1	87,90	COL1A1	Sp1	1277	6667	Gene	Gene	expression|compound|START_ENTITY repressor|nmod|expression acts|nmod|repressor acts|advcl|interacting interacting|nmod|factors factors|compound|END_ENTITY	B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts .
14734826	0	COL1A1	105,111	Sp1	81,84	COL1A1	Sp1	1277	6667	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Rapid genotyping of the osteoporosis-associated polymorphic transcription factor Sp1 binding site in the COL1A1 gene by pyrosequencing .
15241219	0	COL1A1	66,72	Sp1	33,36	COL1A1	Sp1	1277	6667	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|amod|END_ENTITY	Association of otosclerosis with Sp1 binding site polymorphism in COL1A1 gene : evidence for a shared genetic etiology with osteoporosis .
15466008	0	COL1A1	58,64	Sp1	33,36	COL1A1	Sp1	1277	6667	Gene	Gene	gene|compound|START_ENTITY sites|nmod|gene sites|amod|END_ENTITY	Common variants at the PCOL2 and Sp1 binding sites of the COL1A1 gene and their interactive effect influence bone_mineral_density in Caucasians .
15952128	0	COL1A1	77,83	Sp1	56,59	COL1A1	Sp1	1277	6667	Gene	Gene	gene|nummod|START_ENTITY sites|nmod|gene sites|amod|END_ENTITY	-LSB- Association analysis on the polymorphisms of PCOL2 and Sp1 binding sites of COL1A1 gene and the congenital_dislocation_of_the_hip in Chinese population -RSB- .
17332715	0	COL1A1	17,23	Sp1	25,28	COL1A1	Sp1	1277	6667	Gene	Gene	Collagen_type_1|dep|START_ENTITY polymorphism|amod|Collagen_type_1 polymorphism|amod|END_ENTITY	Collagen_type_1 -LRB- COL1A1 -RRB- Sp1 binding site polymorphism is associated with osteoporotic_fractures but not with bone density in post-menopausal women from the Canary Islands : a preliminary study .
18694864	0	COL1A1	25,31	Sp1	136,139	COL1A1	Sp1	1277	6667	Gene	Gene	polymorphism|compound|START_ENTITY associated|nsubjpass|polymorphism associated|nmod|that that|nmod|site site|amod|END_ENTITY	A novel , non-functional , COL1A1 polymorphism is not associated with lumbar_disk_disease in young male Greek subjects unlike that of the Sp1 site .
22057139	0	COL1A1	89,95	Sp1	65,68	COL1A1	Sp1	1277	6667	Gene	Gene	gene|compound|START_ENTITY site|nmod|gene site|amod|END_ENTITY	A haplotype derived from the common variants at the -1997 G/T and Sp1 binding site of the COL1A1 gene influences risk of postmenopausal_osteoporosis in India .
24398012	0	COL1A1	40,46	Sp1	3,6	COL1A1	Sp1	1277	6667	Gene	Gene	polymorphism|nmod|START_ENTITY gene|dep|polymorphism gene|nsubj|END_ENTITY	Is Sp1 binding site polymorphism within COL1A1 gene associated with tennis_elbow ?
24566004	0	COL1A1	44,50	Sp1	52,55	COL1A1	Sp1	1277	6667	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Combined effects of collagen_type_I_alpha1 -LRB- COL1A1 -RRB- Sp1 polymorphism and osteoporosis risk factors on bone_mineral_density in Turkish postmenopausal women .
9840444	0	COL1A1	72,78	Sp1	95,98	COL1A1	Sp1	1277	6667	Gene	Gene	gene|appos|START_ENTITY expression|nmod|gene Modulation|nmod|expression Modulation|dep|elements elements|amod|END_ENTITY	Modulation of basal expression of the human alpha1 -LRB- I -RRB- procollagen gene -LRB- COL1A1 -RRB- by tandem NF-1 / Sp1 promoter elements in normal human dermal fibroblasts .
26995940	0	COL1A1	31,37	collagen_1A1	17,29	COL1A1	collagen 1A1	1277	1277	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of collagen_1A1 -LRB- COL1A1 -RRB- gene and their relation to bone mineral density in postmenopausal women .
23036951	0	COL1A1	92,98	collagen_type_I	75,90	COL1A1	collagen type I	1277	1277	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Controlling fibrous capsule formation through long-term down-regulation of collagen_type_I -LRB- COL1A1 -RRB- expression by nanofiber-mediated siRNA gene silencing .
24566004	0	COL1A1	44,50	collagen_type_I_alpha1	20,42	COL1A1	collagen type I alpha1	1277	1277	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Combined effects of collagen_type_I_alpha1 -LRB- COL1A1 -RRB- Sp1 polymorphism and osteoporosis risk factors on bone_mineral_density in Turkish postmenopausal women .
2220807	0	COL1A1	213,219	type_I_procollagen	188,206	COL1A1	type I procollagen	1277	1278	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phenotypic heterogeneity in osteogenesis_imperfecta : the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type_I_procollagen gene -LRB- COL1A1 -RRB- .
2901225	0	COL1A2	83,89	P450pcn1	23,31	COL1A2	P450pcn1	1278	1576	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	The gene CYP3 encoding P450pcn1 -LRB- nifedipine_oxidase -RRB- is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22 .1 .
12920208	0	COL1A2	92,98	alpha_2_type_I_collagen	62,85	COL1A2	alpha 2 type I collagen	1278	1278	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	5-fluorouracil blocks transforming_growth_factor-beta-induced alpha_2_type_I_collagen gene -LRB- COL1A2 -RRB- expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation .
1860834	0	COL2A1	50,56	cartilage_procollagen_gene	22,48	COL2A1	cartilage procollagen gene	1280	1280	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of a human cartilage_procollagen_gene -LRB- COL2A1 -RRB- in mouse 3T3 cells .
7700721	0	COL2A1	52,58	collagen_II	39,50	COL2A1	collagen II	1280	1280	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Kniest_dysplasia is caused by dominant collagen_II -LRB- COL2A1 -RRB- mutations : parental somatic mosaicism manifesting as Stickler phenotype and mild spondyloepiphyseal_dysplasia .
9915573	0	COL2A1	79,85	collagen_type_II	61,77	COL2A1	collagen type II	1280	1280	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Restoration of normal bone development by human homologue of collagen_type_II -LRB- COL2A1 -RRB- gene in Col2a1 null mice .
15082485	0	COL2A1	82,88	collagen_type_II_alpha1	57,80	COL2A1	collagen type II alpha1	1280	1280	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Insulin-like growth factor I gene promoter polymorphism , collagen_type_II_alpha1 -LRB- COL2A1 -RRB- gene , and the prevalence of radiographic_osteoarthritis : the Rotterdam Study .
24700772	0	COL3A1	18,24	PLAG1	75,80	COL3A1	PLAG1	1281	5324	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma .
26687111	0	COL6A3	76,82	DYT27	94,99	COL6A3	DYT27	1293	1293	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	The clinical phenotype of early-onset isolated_dystonia caused by recessive COL6A3 mutations -LRB- DYT27 -RRB- .
24398995	0	COL6A3	68,74	EDNRB	76,81	COL6A3	EDNRB	396548(Tax:9031)	408082(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	COL6A3	68,74	IGF2R	55,60	COL6A3	IGF2R	396548(Tax:9031)	395817(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	COL6A3	68,74	KLF6	83,87	COL6A3	KLF6	396548(Tax:9031)	420463(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	COL6A3	68,74	RGS2	62,66	COL6A3	RGS2	396548(Tax:9031)	378912(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	COL6A3	68,74	folr1	48,53	COL6A3	folr1	396548(Tax:9031)	395638(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
25337653	0	COL6A3	0,6	leptin	23,29	COL6A3	leptin	1293	3952	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	COL6A3 is regulated by leptin in human adipose_tissue and reduced in obesity .
21471992	0	COL7A1	15,21	HB-EGF	0,6	COL7A1	HB-EGF	1294	1839	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	HB-EGF induces COL7A1 expression in keratinocytes and fibroblasts : possible mechanism underlying allogeneic fibroblast therapy in recessive_dystrophic_epidermolysis_Bullosa .
1358979	0	COL7A1	42,48	collagen_VII	28,40	COL7A1	collagen VII	1294	1294	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic linkage between the collagen_VII -LRB- COL7A1 -RRB- gene and the autosomal dominant form of dystrophic_epidermolysis_bullosa in two Dutch kindreds .
16440132	0	COL9A2	86,92	EDM2	103,107	COL9A2	EDM2	1298	1298	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Intrafamilial phenotypic diversity in multiple epiphyseal_dysplasia associated with a COL9A2 mutation -LRB- EDM2 -RRB- .
11420783	0	COLIA1	8,14	Sp1	4,7	COLIA1	Sp1	1277	6667	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The Sp1 COLIA1 gene polymorphism , and not vitamin_D_receptor or estrogen_receptor gene polymorphisms , determines bone_mineral_density in postmenopausal Greek women .
9738510	0	COLIA1	40,46	Sp1	3,6	COLIA1	Sp1	1277	6667	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|amod|END_ENTITY	An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic_fractures in both men and women .
17551768	0	COLIA1	67,73	collagen_type_I_alpha1	43,65	COLIA1	collagen type I alpha1	1277	1277	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The -1997 _ G/T and Sp1 polymorphisms in the collagen_type_I_alpha1 -LRB- COLIA1 -RRB- gene in relation to changes in femoral neck bone_mineral_density and the risk of fracture in the elderly : the Rotterdam study .
10913946	0	COLIA1	66,72	collagen_type_I_alpha_1	41,64	COLIA1	collagen type I alpha 1	1277	1277	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Sp1 binding site polymorphism in the collagen_type_I_alpha_1 -LRB- COLIA1 -RRB- gene is not associated with bone_mineral_density in healthy children , adolescents , and young adults .
12065405	0	COMATOSE	49,57	ALDP	94,98	COMATOSE	ALDP	830144(Tax:3702)	215	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Control of germination and lipid mobilization by COMATOSE , the Arabidopsis homologue of human ALDP .
16293123	0	COMMD1	24,30	MURR1	32,37	COMMD1	MURR1	403590(Tax:9615)	403590(Tax:9615)	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Characterization of the COMMD1 -LRB- MURR1 -RRB- mutation causing copper_toxicosis in Bedlington terriers .
20237237	0	COMMD1	0,6	Nedd4-2	59,66	COMMD1	Nedd4-2	150684	23327	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|END_ENTITY	COMMD1 downregulates the epithelial sodium channel through Nedd4-2 .
26060140	0	COMMD7	0,6	NEMO	18,22	COMMD7	NEMO	149951	8517	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	COMMD7 as a novel NEMO interacting protein involved in the termination of NF-kB signaling .
10661386	0	COMP	37,41	Cartilage_oligomeric_matrix_protein	0,35	COMP	Cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- levels in digital sheath synovial fluid and serum with tendon_injury .
18193163	0	COMP	63,67	TSP-5	57,62	COMP	TSP-5	1311	1311	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Model systems for studying skeletal_dysplasias caused by TSP-5 / COMP mutations .
10343777	0	COMP	51,55	cartilage_oligomeric_matrix_protein	14,49	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- by cultured human dermal and synovial fibroblasts .
11501943	0	COMP	48,52	cartilage_oligomeric_matrix_protein	54,89	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of sequence polymorphisms of the COMP -LRB- cartilage_oligomeric_matrix_protein -RRB- gene and association study in osteoarthrosis of the knee and hip_joints .
11531396	0	COMP	57,61	cartilage_oligomeric_matrix_protein	20,55	COMP	cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in equine carpal articular cartilage and its variation with exercise_and_cartilage_deterioration .
12202123	0	COMP	53,57	cartilage_oligomeric_matrix_protein	16,51	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- correlate with radiographic progression of knee_osteoarthritis .
12405694	0	COMP	52,56	cartilage_oligomeric_matrix_protein	15,50	COMP	cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Correlation of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- levels in equine tendon with mechanical properties : a proposed role for COMP in determining function-specific mechanical characteristics of locomotor tendons .
12792737	0	COMP	60,64	cartilage_oligomeric_matrix_protein	23,58	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations of the cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- gene in two Japanese patients with pseudoachondroplasia .
15607888	0	COMP	26,30	cartilage_oligomeric_matrix_protein	32,67	COMP	cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	Enhanced concentration of COMP -LRB- cartilage_oligomeric_matrix_protein -RRB- in osteochondral_fractures from racing Thoroughbreds .
15639635	0	COMP	60,64	cartilage_oligomeric_matrix_protein	23,58	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	Serum concentration of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- is sensitive to physiological cyclic loading in healthy adults .
16005620	0	COMP	75,79	cartilage_oligomeric_matrix_protein	38,73	COMP	cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	immunolocalization|appos|START_ENTITY immunolocalization|nmod|END_ENTITY	Ultrastructural immunolocalization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in relation to collagen fibrils in the equine tendon .
17156423	0	COMP	53,57	cartilage_oligomeric_matrix_protein	16,51	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- increase temporarily after physical exercise in patients with knee_osteoarthritis .
17657676	0	COMP	43,47	cartilage_oligomeric_matrix_protein	6,41	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- levels in knee_osteoarthritis in a Brazilian population : clinical and radiological correlation .
18840965	0	COMP	49,53	cartilage_oligomeric_matrix_protein	12,47	COMP	cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in synovial fluid , serum and urine from 51 racehorses with carpal_bone_fracture .
19237461	0	COMP	89,93	cartilage_oligomeric_matrix_protein	52,87	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	reduction|appos|START_ENTITY reduction|nmod|END_ENTITY	Ribozyme-mediated reduction of wild-type and mutant cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- mRNA and protein .
19716571	0	COMP	75,79	cartilage_oligomeric_matrix_protein	38,73	COMP	cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	immunolocalization|appos|START_ENTITY immunolocalization|nmod|END_ENTITY	Ultrastructural immunolocalization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in the articular cartilage on the equine third carpal bone in trained and untrained horses .
25489544	0	COMP	78,82	cartilage_oligomeric_matrix_protein	41,76	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Thyroid hormones increase collagen I and cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- expression in vitro human tenocytes .
8311563	0	COMP	48,52	cartilage_oligomeric_matrix_protein	11,46	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- into joint fluid after knee_injury and in osteoarthritis .
9164830	0	COMP	75,79	cartilage_oligomeric_matrix_protein	38,73	COMP	cartilage oligomeric matrix protein	281088(Tax:9913)	281088(Tax:9913)	Gene	Gene	immunolocalization|appos|START_ENTITY immunolocalization|nmod|END_ENTITY	Ultrastructural immunolocalization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in porcine growth cartilage .
9501326	0	COMP	57,61	cartilage_oligomeric_matrix_protein	20,55	COMP	cartilage oligomeric matrix protein	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in tendon and its variation with tendon site , age and load .
9714346	0	COMP	49,53	cartilage_oligomeric_matrix_protein	12,47	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in synovial fibroblasts and synovial fluids .
9749943	0	COMP	57,61	cartilage_oligomeric_matrix_protein	20,55	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in human normal and pseudoachondroplasia musculoskeletal tissues .
9887340	0	COMP	78,82	cartilage_oligomeric_matrix_protein	41,76	COMP	cartilage oligomeric matrix protein	1311	1311	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Trinucleotide expansion mutations in the cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- gene .
11556837	0	COMT	30,34	Catechol-O-Methyltransferase	0,28	COMT	Catechol-O-Methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Catechol-O-Methyltransferase -LRB- COMT -RRB- gene polymorphism and breast_cancer risk in young women .
25600541	0	COMT	70,74	Catechol-O-Methyltransferase_Gene_Val158Met	25,68	COMT	Catechol-O-Methyltransferase Gene Val158Met	1312	1312	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	The Relationship Between Catechol-O-Methyltransferase_Gene_Val158Met -LRB- COMT -RRB- Polymorphism and Premorbid Cannabis Use in Turkish Male Patients with Schizophrenia .
11693181	0	COMT	30,34	Catechol-O-methyltransferase	0,28	COMT	Catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- genetic polymorphism in a Turkish population .
17510945	0	COMT	43,47	Catechol-O-methyltransferase	0,28	COMT	Catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Catechol-O-methyltransferase polymorphism -LRB- COMT -RRB- in suicide attempters : a possible gender effect on anger traits .
18270997	0	COMT	30,34	Catechol-O-methyltransferase	0,28	COMT	Catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- gene variants : possible association of the Val158Met variant with opiate_addiction in Hispanic women .
20219633	0	COMT	30,34	Catechol-O-methyltransferase	0,28	COMT	Catechol-O-methyltransferase	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- inhibition reduces spinal nociceptive activity .
21934178	0	COMT	30,34	Catechol-O-methyltransferase	0,28	COMT	Catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- gene variants and pain in chronic pancreatitis .
23446089	0	COMT	30,34	Catechol-O-methyltransferase	0,28	COMT	Catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- gene polymorphisms as risk factor in temporomandibular_disorders patients from Southern Italy .
23613844	0	COMT	30,34	Catechol-O-methyltransferase	0,28	COMT	Catechol-O-methyltransferase	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain .
25080080	0	COMT	53,57	Catechol_O-Methyltransferase	23,51	COMT	Catechol O-Methyltransferase	1312	1312	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Medicinal Chemistry of Catechol_O-Methyltransferase -LRB- COMT -RRB- Inhibitors and Their Therapeutic Utility .
12799619	0	COMT	30,34	Catechol_O-methyltransferase	0,28	COMT	Catechol O-methyltransferase	1312	1312	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Catechol_O-methyltransferase -LRB- COMT -RRB- mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia .
24039968	0	COMT	54,58	Catechol_O-methyltransferase	24,52	COMT	Catechol O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between the Catechol_O-methyltransferase -LRB- COMT -RRB- Val158met polymorphism and different dimensions of impulsivity .
16564429	0	COMT	104,108	MTHFR	62,67	COMT	MTHFR	1312	4524	Gene	Gene	methylenetetrahydrofolate_reductase|appos|START_ENTITY methylenetetrahydrofolate_reductase|appos|END_ENTITY	Genetic investigation of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and catechol-O-methyl_transferase -LRB- COMT -RRB- in multiple_sclerosis .
22890010	0	COMT	15,19	RFC-1	40,45	COMT	RFC-1	1312	5981	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of COMT , MTHFR , and SLC19A1 -LRB- RFC-1 -RRB- polymorphisms with homocysteine blood levels and cognitive_impairment in Parkinson 's _ disease .
17467918	0	COMT	47,51	catechol-O-methyl-transferase	16,45	COMT	catechol-O-methyl-transferase	1312	1312	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Manipulation of catechol-O-methyl-transferase -LRB- COMT -RRB- activity to influence the attenuation of substance seeking behavior , a subtype of Reward_Deficiency_Syndrome -LRB- RDS -RRB- , is dependent upon gene polymorphisms : a hypothesis .
20974455	0	COMT	57,61	catechol-O-methyl-transferase	26,55	COMT	catechol-O-methyl-transferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Nonsynonimous mutation of catechol-O-methyl-transferase -LRB- COMT -RRB- gene in a patient with temporomandibular_disorder .
593427	0	COMT	41,45	catechol-O-methyl-transferase	10,39	COMT	catechol-O-methyl-transferase	1312	1312	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Effect of catechol-O-methyl-transferase -LRB- COMT -RRB- inhibition on the vascular and metabolic responses to noradrenaline , isoprenaline and sympathetic nerve stimulation in canine subcutaneous adipose tissue .
16505837	0	COMT	35,39	catechol-O-methyl_transferase	4,33	COMT	catechol-O-methyl transferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The catechol-O-methyl_transferase -LRB- COMT -RRB- gene as a candidate for psychiatric phenotypes : evidence and lessons .
19603	0	COMT	66,70	catechol-O-methyl_transferase	35,64	COMT	catechol-O-methyl transferase	1312	1312	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Differential influence of block of catechol-O-methyl_transferase -LRB- COMT -RRB- activity and of neuronal uptake on alpha - and beta-adrenergic effects .
19895544	0	COMT	81,85	catechol-O-methyl_transferase	50,79	COMT	catechol-O-methyl transferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Study : the lack of significant association of the catechol-O-methyl_transferase -LRB- COMT -RRB- gene polymorphism in violent offenders with mental_retardation .
20643532	0	COMT	35,39	catechol-O-methyl_transferase	4,33	COMT	catechol-O-methyl transferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The catechol-O-methyl_transferase -LRB- COMT -RRB- gene and its potential association with schizophrenia : findings from a large German case-control and family-based sample .
21344643	0	COMT	46,50	catechol-O-methyl_transferase	15,44	COMT	catechol-O-methyl transferase	1312	1312	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of catechol-O-methyl_transferase -LRB- COMT -RRB- gene -287 A/G polymorphism with susceptibility to obsessive-compulsive_disorder in Chinese Han population .
10755376	0	COMT	105,109	catechol-O-methyltransferase	75,103	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Gas chromatographic-mass spectrometric procedures for determination of the catechol-O-methyltransferase -LRB- COMT -RRB- activity and for detection of unstable catecholic metabolites in human and rat liver preparations after COMT catalyzed in statu nascendi derivatization using S-adenosylmethionine .
11121178	0	COMT	68,72	catechol-O-methyltransferase	38,66	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Exploratory association study between catechol-O-methyltransferase -LRB- COMT -RRB- high/low enzyme activity polymorphism and hypnotizability .
11489299	0	COMT	90,94	catechol-O-methyltransferase	60,88	COMT	catechol-O-methyltransferase	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of intracerebral 6-nitronoradrenaline , an endogenous catechol-O-methyltransferase -LRB- COMT -RRB- inhibitor , on striatal dopamine metabolism in anaesthetised rats .
11706521	0	COMT	60,64	catechol-O-methyltransferase	30,58	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Limited association between a catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and breast_cancer risk in Japan .
11900601	0	COMT	50,54	catechol-O-methyltransferase	20,48	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and severe alcoholic_withdrawal_symptoms in male Japanese alcoholics .
1347500	0	COMT	40,44	catechol-O-methyltransferase	10,38	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human catechol-O-methyltransferase -LRB- COMT -RRB- gene maps to band q11 .2 of chromosome 22 and shows a frequent RFLP with BglI .
15583953	0	COMT	59,63	catechol-O-methyltransferase	29,57	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Negative association between catechol-O-methyltransferase -LRB- COMT -RRB- gene Val158Met polymorphism and persistent tardive_dyskinesia in schizophrenia .
15927391	0	COMT	70,74	catechol-O-methyltransferase	40,68	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Val158Met polymorphism of the human catechol-O-methyltransferase -LRB- COMT -RRB- gene may influence morphine requirements in cancer_pain patients .
16395295	0	COMT	57,61	catechol-O-methyltransferase	27,55	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Significant association of catechol-O-methyltransferase -LRB- COMT -RRB- haplotypes with nicotine_dependence in male and female smokers of two ethnic populations .
16583437	0	COMT	145,149	catechol-O-methyltransferase	115,143	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence for monozygotic twin -LRB- MZ -RRB- discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase -LRB- COMT -RRB- gene .
17963454	0	COMT	81,85	catechol-O-methyltransferase	51,79	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Management of L-Dopa related hyperhomocysteinemia : catechol-O-methyltransferase -LRB- COMT -RRB- inhibitors or B vitamins ?
18189241	0	COMT	51,55	catechol-O-methyltransferase	21,49	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the catechol-O-methyltransferase -LRB- COMT -RRB- gene influence plasma total homocysteine levels .
18424907	0	COMT	60,64	catechol-O-methyltransferase	30,58	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Val158Met polymorphism in the catechol-O-methyltransferase -LRB- COMT -RRB- gene is not associated with tardive_dyskinesia in schizophrenia .
18752908	0	COMT	34,38	catechol-O-methyltransferase	4,32	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The catechol-O-methyltransferase -LRB- COMT -RRB- gene polymorphism and prevalence of uterine fibroids .
19094200	0	COMT	55,59	catechol-O-methyltransferase	25,53	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the catechol-O-methyltransferase -LRB- COMT -RRB- gene and morphine requirements in cancer patients with pain .
19290789	0	COMT	53,57	catechol-O-methyltransferase	23,51	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association studies of catechol-O-methyltransferase -LRB- COMT -RRB- gene with schizophrenia and response to antipsychotic treatment .
19605895	0	COMT	43,47	catechol-O-methyltransferase	13,41	COMT	catechol-O-methyltransferase	445450(Tax:9615)	445450(Tax:9615)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of catechol-O-methyltransferase -LRB- COMT -RRB- genotypes on the prognosis of canine mammary_tumors .
19700233	0	COMT	45,49	catechol-O-methyltransferase	15,43	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and academic achievement in a Chinese cohort .
20374420	0	COMT	46,50	catechol-O-methyltransferase	16,44	COMT	catechol-O-methyltransferase	12846(Tax:10090)	12846(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Distribution of catechol-O-methyltransferase -LRB- COMT -RRB- proteins and enzymatic activities in wild-type and soluble COMT deficient mice .
20434465	0	COMT	71,75	catechol-O-methyltransferase	41,69	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The flexible mind is associated with the catechol-O-methyltransferase -LRB- COMT -RRB- Val158Met polymorphism : evidence for a role of dopamine in the control of task-switching .
20483479	0	COMT	66,70	catechol-O-methyltransferase	36,64	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of association between the catechol-O-methyltransferase -LRB- COMT -RRB- gene and negative symptoms in chronic schizophrenia .
22100850	0	COMT	63,67	catechol-O-methyltransferase	33,61	COMT	catechol-O-methyltransferase	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Complex estrogenic regulation of catechol-O-methyltransferase -LRB- COMT -RRB- in rats .
22180998	0	COMT	92,96	catechol-O-methyltransferase	62,90	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	How to consistently link extraversion and intelligence to the catechol-O-methyltransferase -LRB- COMT -RRB- gene : on defining and measuring psychological phenotypes in neurogenetic research .
22417933	0	COMT	47,51	catechol-O-methyltransferase	17,45	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in the catechol-O-methyltransferase -LRB- COMT -RRB- gene and treatment response to venlafaxine_XR in generalized_anxiety_disorder .
22483293	0	COMT	46,50	catechol-O-methyltransferase	16,44	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of the catechol-O-methyltransferase -LRB- COMT -RRB- gene in personality and related psychopathological_disorders .
23178897	0	COMT	39,43	catechol-O-methyltransferase	4,32	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The catechol-O-methyltransferase gene -LRB- COMT -RRB- and cognitive function from childhood through adolescence .
23209597	0	COMT	99,103	catechol-O-methyltransferase	69,97	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigating the genetic basis of theory of mind -LRB- ToM -RRB- : the role of catechol-O-methyltransferase -LRB- COMT -RRB- gene polymorphisms .
23613951	0	COMT	60,64	catechol-O-methyltransferase	30,58	COMT	catechol-O-methyltransferase	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Sexually dimorphic effects of catechol-O-methyltransferase -LRB- COMT -RRB- inhibition on dopamine metabolism in multiple brain regions .
23939469	0	COMT	76,80	catechol-O-methyltransferase	46,74	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The associations between the Val158Met in the catechol-O-methyltransferase -LRB- COMT -RRB- gene and the risk of uterine_leiomyoma -LRB- ULM -RRB- .
24040167	0	COMT	135,139	catechol-O-methyltransferase	105,133	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Assessment of cellular estrogenic activity based on estrogen_receptor-mediated reduction of soluble-form catechol-O-methyltransferase -LRB- COMT -RRB- expression in an ELISA-based system .
24762091	0	COMT	82,86	catechol-O-methyltransferase	52,80	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase -LRB- COMT -RRB- gene Val158Met polymorphism .
24955500	0	COMT	72,76	catechol-O-methyltransferase	42,70	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Perceived stress during pregnancy and the catechol-O-methyltransferase -LRB- COMT -RRB- rs165599 polymorphism impacts on childhood IQ .
24956262	0	COMT	54,58	catechol-O-methyltransferase	24,52	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between the catechol-O-methyltransferase -LRB- COMT -RRB- Val158Met polymorphism and manual aiming control in healthy subjects .
25963102	0	COMT	70,74	catechol-O-methyltransferase	40,68	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotype status of the dopamine-related catechol-O-methyltransferase -LRB- COMT -RRB- gene corresponds with desirability of `` unhealthy '' foods .
26450530	0	COMT	50,54	catechol-O-methyltransferase	20,48	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Fetal Val108/158Met catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and placental COMT activity are associated with the development of preeclampsia .
7172441	0	COMT	106,110	catechol-O-methyltransferase	76,104	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Radioenzymatic assay of plasma adrenaline and noradrenaline : evidence for a catechol-O-methyltransferase -LRB- COMT -RRB- inhibiting factor associated with essential hypertension .
8615170	0	COMT	41,45	catechol-O-methyltransferase	11,39	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Effects of catechol-O-methyltransferase -LRB- COMT -RRB- inhibition on the pharmacokinetics of L-DOPA .
8950414	0	COMT	71,75	catechol-O-methyltransferase	41,69	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a BglI polymorphism of catechol-O-methyltransferase -LRB- COMT -RRB- gene , and association study with schizophrenia .
9159741	0	COMT	54,58	catechol-O-methyltransferase	24,52	COMT	catechol-O-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	G/A1947 polymorphism in catechol-O-methyltransferase -LRB- COMT -RRB- gene in Parkinson 's _ disease .
9365014	0	COMT	159,163	catechol-O-methyltransferase	129,157	COMT	catechol-O-methyltransferase	712548(Tax:9544)	712548(Tax:9544)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Cerebral 6 - -LSB- 18F -RSB- fluoro-L-DOPA uptake in rhesus_monkey : pharmacological influence of aromatic_amino_acid decarboxylase -LRB- AAAD -RRB- and catechol-O-methyltransferase -LRB- COMT -RRB- inhibition .
23219927	0	COMT	102,106	catechol-o-methyl_transferase	71,100	COMT	catechol-o-methyl transferase	1312	1312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Prefrontal_white_matter_impairment in substance users depends upon the catechol-o-methyl_transferase -LRB- COMT -RRB- val158met polymorphism .
6343177	0	COMT	64,68	catechol-o-methyl_transferase	33,62	COMT	catechol-o-methyl transferase	1312	1312	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunoperoxidase localization of catechol-o-methyl_transferase -LRB- COMT -RRB- in human breast_cancer .
10898913	0	COMT	88,92	catechol-o-methyltransferase	58,86	COMT	catechol-o-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between the functional variant of the catechol-o-methyltransferase -LRB- COMT -RRB- gene and early-onset alcoholism associated with severe antisocial_behavior .
11054777	0	COMT	170,174	catechol-o-methyltransferase	140,168	COMT	catechol-o-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Long forms of the dopamine receptor -LRB- DRD4 -RRB- gene VNTR are more prevalent in substance abusers : no interaction with functional alleles of the catechol-o-methyltransferase -LRB- COMT -RRB- gene .
15124004	0	COMT	46,50	catechol-o-methyltransferase	16,44	COMT	catechol-o-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants in the catechol-o-methyltransferase -LRB- COMT -RRB- gene are associated with schizophrenia in Irish high-density families .
22972758	0	COMT	43,47	catechol-o-methyltransferase	13,41	COMT	catechol-o-methyltransferase	1312	1312	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Study of the catechol-o-methyltransferase -LRB- COMT -RRB- gene with high aggression in children .
24716406	0	COMT	44,48	catechol-o-methyltransferase	14,42	COMT	catechol-o-methyltransferase	1312	1312	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of catechol-o-methyltransferase -LRB- COMT -RRB- by myricetin , dihydromyricetin , and myricitrin .
18802928	0	COMT	50,54	catechol_O-methyltransferase	20,48	COMT	catechol O-methyltransferase	1312	1312	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between catechol_O-methyltransferase -LRB- COMT -RRB- haplotypes and severity of hyperactivity symptoms in adults .
21531374	0	COMT	107,111	catechol_O-methyltransferase	77,105	COMT	catechol O-methyltransferase	1312	1312	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Severe early-onset preeclampsia is not associated with a change in placental catechol_O-methyltransferase -LRB- COMT -RRB- expression .
11735324	0	COMT	98,102	membrane-bound	41,55	COMT	membrane-bound	1312	19	Gene	Gene	catechol-o-methyltransferase|appos|START_ENTITY catechol-o-methyltransferase|amod|END_ENTITY	Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase -LRB- COMT -RRB- estimated by enzyme kinetic values .
23351565	0	COMT	33,37	membrane-bound	18,32	COMT	membrane-bound	1312	19	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability .
24908267	0	CONSTANS-LIKE_7	0,15	phytochrome_B	38,51	CONSTANS-LIKE 7	phytochrome B	831441(Tax:3702)	816394(Tax:3702)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	CONSTANS-LIKE_7 -LRB- COL7 -RRB- is involved in phytochrome_B -LRB- phyB -RRB- - mediated light-quality regulation of auxin homeostasis .
25073793	0	CONSTANS-like_4	4,19	AtCOL4	42,48	CONSTANS-like 4	AtCOL4	832563(Tax:3702)	832563(Tax:3702)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	The CONSTANS-like_4 transcription factor , AtCOL4 , positively regulates abiotic stress tolerance through an abscisic_acid-dependent manner in Arabidopsis .
21525334	0	CONSTITUTIVE_PHOTOMORPHOGENIC1	33,63	FAR-RED_INSENSITIVE219	0,22	CONSTITUTIVE PHOTOMORPHOGENIC1	FAR-RED INSENSITIVE219	817857(Tax:3702)	819244(Tax:3702)	Gene	Gene	activity|nummod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	FAR-RED_INSENSITIVE219 modulates CONSTITUTIVE_PHOTOMORPHOGENIC1 activity via physical interaction to regulate hypocotyl elongation in Arabidopsis .
11967090	0	COP1	81,85	AtMYB21	0,7	COP1	AtMYB21	64326	822401(Tax:3702)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	AtMYB21 , a gene encoding a flower-specific transcription factor , is regulated by COP1 .
23884858	0	COP1	0,4	C/EBPa	13,19	COP1	C/EBPa	64326	1050	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	COP1 targets C/EBPa for degradation and induces acute_myeloid_leukemia via Trib1 .
21625211	0	COP1	38,42	COP9_signalosome_subunit_6	0,26	COP1	COP9 signalosome subunit 6	64326	10980	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	COP9_signalosome_subunit_6 stabilizes COP1 , which functions as an E3 ubiquitin ligase for 14-3-3 .
11226193	0	COP1	12,16	Cip4	0,4	COP1	Cip4	817857(Tax:3702)	833693(Tax:3702)	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	Cip4 , a new COP1 target , is a nucleus-localized positive regulator of Arabidopsis photomorphogenesis .
25777458	0	COP1	0,4	ETV1	32,36	COP1	ETV1	64326	2115	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	COP1 , the negative regulator of ETV1 , influences prognosis in triple-negative_breast_cancer .
25884720	0	COP1	0,4	ETV1	32,36	COP1	ETV1	64326	2115	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	COP1 , the negative regulator of ETV1 , influences prognosis in triple-negative_breast_cancer .
12061902	0	COP1	95,99	HY5	76,79	COP1	HY5	817857(Tax:3702)	830996(Tax:3702)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	HFR1 , a phytochrome_A-signalling component , acts in a separate pathway from HY5 , downstream of COP1 in Arabidopsis_thaliana .
22760208	0	COP1	50,54	PFT1	29,33	COP1	PFT1	817857(Tax:3702)	839141(Tax:3702)	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	The mediator complex subunit PFT1 interferes with COP1 and HY5 in the regulation of Arabidopsis light signaling .
11461903	0	COP1	79,83	SPA1	50,54	COP1	SPA1	817857(Tax:3702)	819242(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The phytochrome_A-specific signaling intermediate SPA1 interacts directly with COP1 , a constitutive repressor of light signaling in Arabidopsis .
21511871	0	COP1	59,63	SPA1	42,46	COP1	SPA1	817857(Tax:3702)	819242(Tax:3702)	Gene	Gene	activity|nummod|START_ENTITY suppress|dobj|activity interacts|xcomp|suppress interacts|nmod|END_ENTITY	Arabidopsis cryptochrome_1 interacts with SPA1 to suppress COP1 activity in response to blue light .
21514160	0	COP1	61,65	SPA1	46,50	COP1	SPA1	817857(Tax:3702)	819242(Tax:3702)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|interaction interaction|nmod|CRY2 CRY2|nmod|END_ENTITY	Blue light-dependent interaction of CRY2 with SPA1 regulates COP1 activity and floral initiation in Arabidopsis .
16794074	0	COP1	35,39	TRB3	0,4	COP1	TRB3	26374(Tax:10090)	228775(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism .
15103385	0	COP1	21,25	p53	62,65	COP1	p53	64326	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The ubiquitin ligase COP1 is a critical negative regulator of p53 .
15280670	0	COP1	21,25	p53	4,7	COP1	p53	64326	7157	Gene	Gene	found|nsubjpass|START_ENTITY wagon|dep|found wagon|compound|END_ENTITY	The p53 paddy wagon : COP1 , Pirh2 and MDM2 are found resisting apoptosis and growth_arrest .
15492238	0	COP1	0,4	p53	32,35	COP1	p53	64326	7157	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	COP1 , the negative regulator of p53 , is overexpressed in breast and ovarian_adenocarcinomas .
15861129	0	COP1	55,59	p53	36,39	COP1	p53	114769	7157	Gene	Gene	suppressing|dobj|START_ENTITY regulates|advcl|suppressing regulates|dobj|END_ENTITY	Myeloid_leukemia_factor_1 regulates p53 by suppressing COP1 via COP9_signalosome_subunit_3 .
11854419	0	COP9	170,174	CSN1	154,158	COP9	CSN1	827049(Tax:3702)	825286(Tax:3702)	Gene	Gene	subunit|nmod|START_ENTITY subunit|nummod|END_ENTITY	CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins : a structure-function study of CSN1 subunit of COP9 signalosome .
17251548	0	COP9	41,45	Retinoblastoma	0,14	COP9	Retinoblastoma	10920	5925	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Retinoblastoma protein regulation by the COP9 signalosome .
10588842	0	COP9	21,25	SGN3	52,56	COP9	SGN3	10920	8533	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hemizygosity for the COP9 signalosome subunit gene , SGN3 , in the Smith-Magenis_syndrome .
21625211	0	COP9_signalosome_subunit_6	0,26	COP1	38,42	COP9 signalosome subunit 6	COP1	10980	64326	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	COP9_signalosome_subunit_6 stabilizes COP1 , which functions as an E3 ubiquitin ligase for 14-3-3 .
23187808	0	COP9_signalosome_subunit_6	52,78	p57	14,17	COP9 signalosome subunit 6	p57	10980	1028	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	CDK inhibitor p57 -LRB- Kip2 -RRB- is negatively regulated by COP9_signalosome_subunit_6 .
17564249	0	COPD	52,56	Microsomal_epoxide_hydrolase	0,28	COPD	Microsomal epoxide hydrolase	260431	2052	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Microsomal_epoxide_hydrolase is not associated with COPD in a community-based sample .
21228423	0	COPD	41,45	Vitamin_D-binding_protein	0,25	COPD	Vitamin D-binding protein	260431	2638	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Vitamin_D-binding_protein contributes to COPD by activation of alveolar macrophages .
21565439	0	COPD	63,67	Yin_Yang_1	0,10	COPD	Yin Yang 1	260431	7528	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Yin_Yang_1 expression and localisation in quadriceps muscle in COPD .
10497389	0	COPD	65,69	chronic_obstructive_pulmonary_disease	26,63	COPD	chronic obstructive pulmonary disease	260431	260431	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Genetic risk factors for chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
18398787	0	COPD	138,142	chronic_obstructive_pulmonary_disease	99,136	COPD	chronic obstructive pulmonary disease	260431	260431	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Friend or foe : combination therapy with inhaled corticosteroids and long-acting beta2-agonists in chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
20662279	0	COPD	108,112	chronic_obstructive_pulmonary_disease	69,106	COPD	chronic obstructive pulmonary disease	260431	260431	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Preanesthetic evaluation , preparation and prognostic prediction for chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
22828230	0	COPD	152,156	chronic_obstructive_pulmonary_disease	113,150	COPD	chronic obstructive pulmonary disease	260431	260431	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The role of the quality of hospital discharge records on the comparative evaluation of outcomes : the example of chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
21920889	0	COPD	0,4	pentraxin-3	69,80	COPD	pentraxin-3	260431	5806	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|nmod|END_ENTITY	COPD is associated with reduced pulmonary interstitial expression of pentraxin-3 .
10995575	0	COPG2	28,33	gamma2-COP	16,26	COPG2	gamma2-COP	26958	26958	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The novel gene , gamma2-COP -LRB- COPG2 -RRB- , in the 7q32 imprinted domain escapes genomic imprinting .
15843967	0	COPINE_1	69,77	BONZAI_1	60,68	COPINE 1	BONZAI 1	836311(Tax:3702)	836311(Tax:3702)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Transgenic expression of the von_Willebrand A domain of the BONZAI_1 / COPINE_1 protein triggers a lesion-mimic phenotype in Arabidopsis .
12393187	0	COQ5	15,19	Mig1p	51,56	COQ5	Mig1p	854930(Tax:4932)	852848(Tax:4932)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The yeast gene COQ5 is differentially regulated by Mig1p , Rtg3p and Hap2p .
10894940	0	CORT	50,54	preprocortistatin	26,43	CORT	preprocortistatin	1325	1325	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fine mapping of the human preprocortistatin gene -LRB- CORT -RRB- to neuroblastoma consensus deletion region 1p36 .3 -- > p36 .2 , but absence of mutations in primary_tumors .
24265246	0	COT	0,3	Pin1	36,40	COT	Pin1	1326	5300	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast_cancer .
10619353	0	COUP-TF	150,157	estrogen_receptor	8,25	COUP-TF	estrogen receptor	7025	2099	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|Role Role|nmod|END_ENTITY	Role of estrogen_receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor -LRB- COUP-TF -RRB- .
17631058	0	COUP-TF-interacting_protein_2	14,43	CTIP2	45,50	COUP-TF-interacting protein 2	CTIP2	58208(Tax:10090)	58208(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of COUP-TF-interacting_protein_2 -LRB- CTIP2 -RRB- in mouse skin during development and in adulthood .
19366371	0	COUP-TF-interacting_protein_2	14,43	CTIP2	45,50	COUP-TF-interacting protein 2	CTIP2	64919	64919	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of COUP-TF-interacting_protein_2 -LRB- CTIP2 -RRB- in human atopic_dermatitis and allergic_contact_dermatitis skin .
8622679	0	COUP-TF1	66,74	vHNF1	27,32	COUP-TF1	vHNF1	7025	6928	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1 / Ear3 and COUP-TFII/Arp1 .
11784326	0	COUP-TFI	73,81	chicken_ovalbumin_upstream_promoter-transcription_factor_I	13,71	COUP-TFI	chicken ovalbumin upstream promoter-transcription factor I	100859519	100859519	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|END_ENTITY	Induction of chicken_ovalbumin_upstream_promoter-transcription_factor_I -LRB- COUP-TFI -RRB- gene expression is mediated by ETS factor binding sites .
18387660	0	COUP-TFI	74,82	chicken_ovalbumin_upstream_promoter-transcription_factor_I	14,72	COUP-TFI	chicken ovalbumin upstream promoter-transcription factor I	100859519	100859519	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of chicken_ovalbumin_upstream_promoter-transcription_factor_I -LRB- COUP-TFI -RRB- in bladder_transitional_cell_carcinoma .
24227652	0	COUP-TFI	0,8	tyrosine_hydroxylase	37,57	COUP-TFI	tyrosine hydroxylase	13865(Tax:10090)	21823(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	COUP-TFI controls activity-dependent tyrosine_hydroxylase expression in adult dopaminergic olfactory bulb interneurons .
23406903	0	COUP-TFII	14,23	BRG1	0,4	COUP-TFII	BRG1	11819(Tax:10090)	20586(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development .
25940145	0	COUP-TFII	0,9	Dentin_Sialophosphoprotein	21,47	COUP-TFII	Dentin Sialophosphoprotein	113984(Tax:10116)	25254(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	COUP-TFII Stimulates Dentin_Sialophosphoprotein Expression and Mineralization in Odontoblasts .
20219888	0	COUP-TFII	35,44	ERalpha	15,22	COUP-TFII	ERalpha	11819(Tax:10090)	13982(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization .
15541767	0	COUP-TFII	18,27	Ets-1	47,52	COUP-TFII	Ets-1	11819(Tax:10090)	23871(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The regulation of COUP-TFII gene expression by Ets-1 is enhanced by the steroid receptor co-activators .
19401563	0	COUP-TFII	87,96	SCF	0,3	COUP-TFII	SCF	7026	4254	Gene	Gene	regulating|dobj|START_ENTITY induces|advcl|regulating induces|nsubj|END_ENTITY	SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII .
12525252	0	COUP-TFII	106,115	chicken_ovalbumin_upstream_promoter-transcription_factor_II	45,104	COUP-TFII	chicken ovalbumin upstream promoter-transcription factor II	386585(Tax:9031)	386585(Tax:9031)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Activation of the MAP kinase pathway induces chicken_ovalbumin_upstream_promoter-transcription_factor_II -LRB- COUP-TFII -RRB- expression in human breast_cancer cell lines .
22493443	0	COUP-TFII	85,94	chicken_ovalbumin_upstream_promoter-transcription_factor_II	24,83	COUP-TFII	chicken ovalbumin upstream promoter-transcription factor II	386585(Tax:9031)	386585(Tax:9031)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Orphan nuclear receptor chicken_ovalbumin_upstream_promoter-transcription_factor_II -LRB- COUP-TFII -RRB- protein negatively regulates bone_morphogenetic_protein_2-induced osteoblast differentiation through suppressing runt-related gene 2 -LRB- Runx2 -RRB- activity .
15331176	0	COUP-TFII	39,48	hTERT	99,104	COUP-TFII	hTERT	7026	7015	Gene	Gene	START_ENTITY|xcomp|inhibiting inhibiting|nmod|transcription transcription|compound|END_ENTITY	The evidences of human orphan receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription .
15506639	0	COUP-TFII	40,49	hTERT	67,72	COUP-TFII	hTERT	7026	7015	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells .
20978203	0	COUP-TFII	17,26	vascular_endothelial_growth_factor	86,120	COUP-TFII	vascular endothelial growth factor	7026	7422	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|END_ENTITY	Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular_endothelial_growth_factor / vascular_endothelial_growth_factor receptor-2 signaling .
9826778	0	COUP-TF_II	114,124	p300	149,153	COUP-TF II	p300	11819(Tax:10090)	328572(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The orphan nuclear receptor , COUP-TF_II , inhibits myogenesis by post-transcriptional regulation of MyoD function : COUP-TF_II directly interacts with p300 and myoD .
9826778	0	COUP-TF_II	29,39	p300	149,153	COUP-TF II	p300	11819(Tax:10090)	328572(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY inhibits|nsubj|receptor inhibits|parataxis|interacts interacts|nmod|END_ENTITY	The orphan nuclear receptor , COUP-TF_II , inhibits myogenesis by post-transcriptional regulation of MyoD function : COUP-TF_II directly interacts with p300 and myoD .
26895100	0	COUPTFII	55,63	MPC1	0,4	COUPTFII	MPC1	7026	51660	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	MPC1 , a key gene in cancer metabolism , is regulated by COUPTFII in human prostate_cancer .
10411296	0	COX-1	36,41	COX-2	0,5	COX-1	COX-2	17708(Tax:10090)	17709(Tax:10090)	Gene	Gene	uterus|nmod|START_ENTITY compensation|nmod|uterus compensation|compound|END_ENTITY	COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period .
10556836	0	COX-1	40,45	COX-2	62,67	COX-1	COX-2	17708(Tax:10090)	17709(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin_E -LRB- 2 -RRB- production in response to pro-inflammatory signals .
11041909	0	COX-1	119,124	COX-2	65,70	COX-1	COX-2	4512	5743	Gene	Gene	inhibitor|advcl|START_ENTITY inhibitor|nsubj|tolerability tolerability|nmod|cyclooxygenase-2 cyclooxygenase-2|appos|END_ENTITY	Gastrointestinal tolerability of the selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis .
11409489	0	COX-1	61,66	COX-2	90,95	COX-1	COX-2	282022(Tax:9913)	282023(Tax:9913)	Gene	Gene	cyclooxygenase-1|dep|START_ENTITY inhibitors|amod|cyclooxygenase-1 inhibitors|appos|END_ENTITY	In-vitro test system for the evaluation of cyclooxygenase-1 -LRB- COX-1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells -LRB- BAECs -RRB- .
11412976	0	COX-1	33,38	COX-2	27,32	COX-1	COX-2	4512	4513	Gene	Gene	selectivity|compound|START_ENTITY Rationale|dep|selectivity Rationale|nmod|END_ENTITY	Rationale for the observed COX-2 / COX-1 selectivity of celecoxib from Monte Carlo simulations .
11577463	0	COX-1	62,67	COX-2	68,73	COX-1	COX-2	4512	4513	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
11577463	0	COX-1	62,67	COX-2	88,93	COX-1	COX-2	4512	4513	Gene	Gene	inhibitor|compound|START_ENTITY aspirin|appos|inhibitor Cyclooxygenase|dep|aspirin Cyclooxygenase|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
11858847	0	COX-1	0,5	COX-2	6,11	COX-1	COX-2	4512	4513	Gene	Gene	START_ENTITY|appos|based based|nsubj|inhibitors inhibitors|compound|END_ENTITY	COX-1 / COX-2 inhibitors based on the methanone moiety .
11966529	0	COX-1	40,45	COX-2	17,22	COX-1	COX-2	26195(Tax:10116)	26198(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Up-regulation of COX-2 by inhibition of COX-1 in the rat : a key to NSAID-induced gastric_injury .
15047734	0	COX-1	30,35	COX-2	130,135	COX-1	COX-2	4512	4513	Gene	Gene	constitutive|appos|START_ENTITY Distribution|nmod|constitutive Distribution|dep|role role|nmod|END_ENTITY	Distribution of constitutive -LRB- COX-1 -RRB- and inducible -LRB- COX-2 -RRB- cyclooxygenase in postviral human liver_cirrhosis : a possible role for COX-2 in the pathogenesis of liver_cirrhosis .
15161995	0	COX-1	10,15	COX-2	16,21	COX-1	COX-2	804478(Tax:9615)	804479(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|inhibition inhibition|compound|END_ENTITY	Effect of COX-1 / COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic_acid and acetylcholine .
15161995	0	COX-1	10,15	COX-2	50,55	COX-1	COX-2	804478(Tax:9615)	804479(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|inhibition inhibition|nmod|inhibition inhibition|compound|END_ENTITY	Effect of COX-1 / COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic_acid and acetylcholine .
15455372	0	COX-1	94,99	COX-2	70,75	COX-1	COX-2	4512	4513	Gene	Gene	expression|compound|START_ENTITY affecting|dobj|expression END_ENTITY|advcl|affecting	Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate_carcinoma cells .
18457826	0	COX-1	14,19	COX-2	20,25	COX-1	COX-2	26195(Tax:10116)	29527(Tax:10116)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|END_ENTITY	Evaluation of COX-1 / COX-2 selectivity and potency of a new class of COX-2 inhibitors .
18457826	0	COX-1	14,19	COX-2	68,73	COX-1	COX-2	26195(Tax:10116)	29527(Tax:10116)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|COX-2 COX-2|nmod|class class|nmod|inhibitors inhibitors|compound|END_ENTITY	Evaluation of COX-1 / COX-2 selectivity and potency of a new class of COX-2 inhibitors .
19097798	0	COX-1	38,43	COX-2	44,49	COX-1	COX-2	17708(Tax:10090)	17709(Tax:10090)	Gene	Gene	isothiazoles|dep|START_ENTITY _|dep|isothiazoles _|amod|END_ENTITY	Diaryl-dithiolanes_and _ - isothiazoles : COX-1 / COX-2 and 5-LOX-inhibitory , * OH scavenging and anti-adhesive activities .
20812280	0	COX-1	80,85	COX-2	87,92	COX-1	COX-2	4512	4513	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Effect of isolated fractions of Harpagophytum procumbens D.C. -LRB- devil 's claw -RRB- on COX-1 , COX-2 activity and nitric_oxide production on whole-blood assay .
21035466	0	COX-1	31,36	COX-2	10,15	COX-1	COX-2	4512	5743	Gene	Gene	dominates|dobj|START_ENTITY dominates|nsubj|END_ENTITY	Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis : mechanisms of COX-2 inhibitor risk to heart_disease .
21035466	0	COX-1	31,36	COX-2	81,86	COX-1	COX-2	4512	5743	Gene	Gene	dominates|dobj|START_ENTITY dominates|dobj|mechanisms mechanisms|nmod|risk risk|compound|END_ENTITY	Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis : mechanisms of COX-2 inhibitor risk to heart_disease .
21629780	0	COX-1	39,44	COX-2	78,83	COX-1	COX-2	17708(Tax:10090)	17709(Tax:10090)	Gene	Gene	START_ENTITY|dep|unaffected unaffected|nmod|inhibition inhibition|nmod|END_ENTITY	Thrombosis is reduced by inhibition of COX-1 , but unaffected by inhibition of COX-2 , in an acute model of platelet activation in the mouse .
22219191	0	COX-1	49,54	COX-2	13,18	COX-1	COX-2	4512	5743	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression Induction|nmod|enzyme enzyme|compound|END_ENTITY	Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide -LRB- LPS -RRB- control prostaglandin_E2 production in astrocytes .
23777557	0	COX-1	143,148	COX-2	149,154	COX-1	COX-2	854598(Tax:4932)	854622(Tax:4932)	Gene	Gene	sites|compound|START_ENTITY sites|amod|active active|amod|END_ENTITY	Dual evaluation of some novel 2-amino-substituted_coumarinylthiazoles as anti-inflammatory-antimicrobial agents and their docking studies with COX-1 / COX-2 active sites .
23874970	0	COX-1	23,28	COX-2	119,124	COX-1	COX-2	17708(Tax:10090)	17709(Tax:10090)	Gene	Gene	drives|nsubj|START_ENTITY drives|xcomp|reveals reveals|dobj|sites sites|nmod|expression expression|compound|END_ENTITY	LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression .
25484897	0	COX-1	93,98	COX-2	99,104	COX-1	COX-2	4512	4513	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Binding Energy Calculation of Patchouli Alcohol Isomer Cyclooxygenase Complexes Suggested as COX-1 / COX-2 Selective Inhibitor .
25866240	0	COX-1	120,125	COX-2	126,131	COX-1	COX-2	4512	4513	Gene	Gene	derivatives|nmod|START_ENTITY evaluation|nmod|derivatives Design|appos|evaluation Design|parataxis|inhibitors inhibitors|nsubj|END_ENTITY	Design , synthesis , biological evaluation and molecular modeling of dihydropyrazole_sulfonamide derivatives as potential COX-1 / COX-2 inhibitors .
27086708	0	COX-1	20,25	COX-2	26,31	COX-1	COX-2	4512	4513	Gene	Gene	lornoxicam|nmod|START_ENTITY lornoxicam|compound|END_ENTITY	Tolerability of the COX-1 / COX-2 inhibitor lornoxicam in the treatment of acute and rheumatic_pain .
7857975	0	COX-1	42,47	COX-2	64,69	COX-1	COX-2	5742	5743	Gene	Gene	constitutive|appos|START_ENTITY constitutive|appos|END_ENTITY	Differential measurement of constitutive -LRB- COX-1 -RRB- and inducible -LRB- COX-2 -RRB- cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays .
9083488	0	COX-1	104,109	COX-2	98,103	COX-1	COX-2	4512	4513	Gene	Gene	Effect|parataxis|START_ENTITY Effect|nmod|END_ENTITY	Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2 / COX-1 selectivity .
9893042	0	COX-1	113,118	COX-2	86,91	COX-1	COX-2	4512	4513	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells .
11122255	0	COX-1	32,37	cyclooxygenase-1	14,30	COX-1	cyclooxygenase-1	5742	5742	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclooxygenase-1 -LRB- COX-1 -RRB- in labial salivary glands of Sj gren 's _ syndrome .
17202703	0	COX-1	90,95	cyclooxygenase-1	72,88	COX-1	cyclooxygenase-1	5742	5742	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 -LRB- COX-1 -RRB- inhibitors .
21372527	0	COX-1	54,59	cyclooxygenase-1	36,52	COX-1	cyclooxygenase-1	5742	5742	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- Significance and creation of novel cyclooxygenase-1 -LRB- COX-1 -RRB- selective inhibitors -RSB- .
16204198	0	COX-1	12,17	mPGES1	21,27	COX-1	mPGES1	17708(Tax:10090)	64292(Tax:10090)	Gene	Gene	Coupling|nmod|START_ENTITY Coupling|nmod|END_ENTITY	Coupling of COX-1 to mPGES1 for prostaglandin_E2 biosynthesis in the murine mammary gland .
12967936	0	COX-1	94,99	sPLA2	87,92	COX-1	sPLA2	26195(Tax:10116)	29692(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2 , COX-1 and COX-2 selective inhibitors , and an LTC4 receptor antagonist .
23777936	0	COX-2	31,36	AIF-1	94,99	COX-2	AIF-1	5743	199	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Influence of Cyclooxygenase-2 -LRB- COX-2 -RRB- gene promoter-1195 and allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- polymorphisms on allograft outcome in Hispanic_kidney_transplant_recipients .
25770423	0	COX-2	19,24	AKT	66,69	COX-2	AKT	4513	207	Gene	Gene	inhibitors|compound|START_ENTITY PTEN|nmod|inhibitors antagonizes|nsubj|PTEN antagonizes|dobj|activation activation|compound|END_ENTITY	Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization .
15639337	2	COX-2	132,137	AP-1	164,168	COX-2	AP-1	17709(Tax:10090)	16476(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	on phorbol_ester-induced COX-2 expression in mouse skin : AP-1 and CREB as potential upstream targets .
18192694	0	COX-2	45,50	AP-1	81,85	COX-2	AP-1	5743	3727	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|activation activation|compound|END_ENTITY	15-Deoxy-Delta12 ,14 - prostaglandin_J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast_cancer cells : a potential role of ROS .
24418675	0	COX-2	61,66	ATF4	14,18	COX-2	ATF4	17709(Tax:10090)	11911(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2 / PGE2 dependent signaling pathway .
15016316	0	COX-2	14,19	Akt	42,45	COX-2	Akt	5743	207	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of COX-2 protein expression by Akt in endometrial_cancer cells is mediated through NF-kappaB/IkappaB pathway .
15067356	0	COX-2	14,19	Akt	0,3	COX-2	Akt	4513	207	Gene	Gene	mRNA|compound|START_ENTITY regulates|dobj|mRNA regulates|nsubj|END_ENTITY	Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial_cancer cells .
16000874	0	COX-2	0,5	Akt	50,53	COX-2	Akt	5743	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	COX-2 inhibits anoikis by activation of the PI-3K / Akt pathway in human bladder_cancer cells .
16044407	0	COX-2	44,49	Akt	100,103	COX-2	Akt	5743	207	Gene	Gene	Inhibition|appos|START_ENTITY expression|nsubj|Inhibition expression|nmod|downregulation downregulation|nmod|transduction transduction|compound|END_ENTITY	Inhibition of TPA-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin through downregulation of Akt signal transduction in human keratinocytes .
18823436	0	COX-2	54,59	Akt	93,96	COX-2	Akt	4513	207	Gene	Gene	inhibitor|compound|START_ENTITY celecoxib|appos|inhibitor effects|nmod|celecoxib effects|nmod|signaling signaling|compound|END_ENTITY	Anti-gastric_cancer effects of celecoxib , a selective COX-2 inhibitor , through inhibition of Akt signaling .
20446020	0	COX-2	51,56	Akt	103,106	COX-2	Akt	5743	207	Gene	Gene	expressions|compound|START_ENTITY inhibits|dobj|expressions inhibits|advcl|suppressing suppressing|advcl|signaling signaling|nsubj|END_ENTITY	17beta-estradiol inhibits prostaglandin_E2-induced COX-2 expressions and cell migration by suppressing Akt and ERK1/2 signaling pathways in human LoVo colon_cancer cells .
20854947	0	COX-2	25,30	Akt	67,70	COX-2	Akt	19225(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transduction transduction|compound|END_ENTITY	Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity .
22214188	0	COX-2	86,91	Akt	30,33	COX-2	Akt	4513	207	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|inhibition inhibition|nmod|END_ENTITY	Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia .
17559081	0	COX-2	38,43	Ang_II	0,6	COX-2	Ang II	26198(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Ang_II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells .
20200402	0	COX-2	62,67	Apoptosis_signal-regulating_kinase_1	0,36	COX-2	Apoptosis signal-regulating kinase 1	4513	4217	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Apoptosis_signal-regulating_kinase_1 in peptidoglycan-induced COX-2 expression in macrophages .
20088789	0	COX-2	28,33	Bid	0,3	COX-2	Bid	17709(Tax:10090)	12122(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Bid mediates anti-apoptotic COX-2 induction through the IKKbeta/NFkappaB pathway due to 5-MCDE exposure .
19272160	0	COX-2	65,70	CD133	85,90	COX-2	CD133	17709(Tax:10090)	19126(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	A MT1-MMP/NF-kappaB signaling axis as a checkpoint controller of COX-2 expression in CD133 + U87 glioblastoma cells .
12608645	0	COX-2	23,28	CD40	0,4	COX-2	CD40	4513	958	Gene	Gene	expression|compound|START_ENTITY triggers|dobj|expression triggers|nsubj|ligation ligation|compound|END_ENTITY	CD40 ligation triggers COX-2 expression in endothelial cells : evidence that CD40-mediated IL-6 synthesis is COX-2-dependent .
18093816	0	COX-2	0,5	CD40	26,30	COX-2	CD40	4513	958	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells .
25342622	0	COX-2	24,29	CD44	45,49	COX-2	CD44	4513	960	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Hyaluronic acid induces COX-2 expression via CD44 in orbital fibroblasts from patients with thyroid-associated_ophthalmopathy .
15013430	0	COX-2	35,40	CDX2	20,24	COX-2	CDX2	5743	1045	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Homeodomain protein CDX2 regulates COX-2 expression in colorectal_cancer .
10411296	0	COX-2	0,5	COX-1	36,41	COX-2	COX-1	17709(Tax:10090)	17708(Tax:10090)	Gene	Gene	compensation|compound|START_ENTITY compensation|nmod|uterus uterus|nmod|END_ENTITY	COX-2 compensation in the uterus of COX-1 deficient mice during the pre-implantation period .
10556836	0	COX-2	62,67	COX-1	40,45	COX-2	COX-1	17709(Tax:10090)	17708(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin_E -LRB- 2 -RRB- production in response to pro-inflammatory signals .
11041909	0	COX-2	65,70	COX-1	119,124	COX-2	COX-1	5743	4512	Gene	Gene	cyclooxygenase-2|appos|START_ENTITY tolerability|nmod|cyclooxygenase-2 inhibitor|nsubj|tolerability inhibitor|advcl|END_ENTITY	Gastrointestinal tolerability of the selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor rofecoxib compared with nonselective COX-1 and COX-2 inhibitors in osteoarthritis .
11409489	0	COX-2	90,95	COX-1	61,66	COX-2	COX-1	282023(Tax:9913)	282022(Tax:9913)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|cyclooxygenase-1 cyclooxygenase-1|dep|END_ENTITY	In-vitro test system for the evaluation of cyclooxygenase-1 -LRB- COX-1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells -LRB- BAECs -RRB- .
11412976	0	COX-2	27,32	COX-1	33,38	COX-2	COX-1	4513	4512	Gene	Gene	Rationale|nmod|START_ENTITY Rationale|dep|selectivity selectivity|compound|END_ENTITY	Rationale for the observed COX-2 / COX-1 selectivity of celecoxib from Monte Carlo simulations .
11577463	0	COX-2	68,73	COX-1	62,67	COX-2	COX-1	4513	4512	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
11577463	0	COX-2	88,93	COX-1	62,67	COX-2	COX-1	4513	4512	Gene	Gene	-RSB-|compound|START_ENTITY Cyclooxygenase|nmod|-RSB- Cyclooxygenase|dep|aspirin aspirin|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
11858847	0	COX-2	6,11	COX-1	0,5	COX-2	COX-1	4513	4512	Gene	Gene	inhibitors|compound|START_ENTITY based|nsubj|inhibitors END_ENTITY|appos|based	COX-1 / COX-2 inhibitors based on the methanone moiety .
11966529	0	COX-2	17,22	COX-1	40,45	COX-2	COX-1	26198(Tax:10116)	26195(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Up-regulation of COX-2 by inhibition of COX-1 in the rat : a key to NSAID-induced gastric_injury .
15047734	0	COX-2	130,135	COX-1	30,35	COX-2	COX-1	4513	4512	Gene	Gene	role|nmod|START_ENTITY Distribution|dep|role Distribution|nmod|constitutive constitutive|appos|END_ENTITY	Distribution of constitutive -LRB- COX-1 -RRB- and inducible -LRB- COX-2 -RRB- cyclooxygenase in postviral human liver_cirrhosis : a possible role for COX-2 in the pathogenesis of liver_cirrhosis .
15161995	0	COX-2	16,21	COX-1	10,15	COX-2	COX-1	804479(Tax:9615)	804478(Tax:9615)	Gene	Gene	inhibition|compound|START_ENTITY Effect|dep|inhibition Effect|nmod|END_ENTITY	Effect of COX-1 / COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic_acid and acetylcholine .
15161995	0	COX-2	50,55	COX-1	10,15	COX-2	COX-1	804479(Tax:9615)	804478(Tax:9615)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|inhibition Effect|dep|inhibition Effect|nmod|END_ENTITY	Effect of COX-1 / COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic_acid and acetylcholine .
15455372	0	COX-2	70,75	COX-1	94,99	COX-2	COX-1	4513	4512	Gene	Gene	START_ENTITY|advcl|affecting affecting|dobj|expression expression|compound|END_ENTITY	Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate_carcinoma cells .
18457826	0	COX-2	20,25	COX-1	14,19	COX-2	COX-1	29527(Tax:10116)	26195(Tax:10116)	Gene	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of COX-1 / COX-2 selectivity and potency of a new class of COX-2 inhibitors .
18457826	0	COX-2	68,73	COX-1	14,19	COX-2	COX-1	29527(Tax:10116)	26195(Tax:10116)	Gene	Gene	inhibitors|compound|START_ENTITY class|nmod|inhibitors COX-2|nmod|class Evaluation|dep|COX-2 Evaluation|nmod|END_ENTITY	Evaluation of COX-1 / COX-2 selectivity and potency of a new class of COX-2 inhibitors .
19097798	0	COX-2	44,49	COX-1	38,43	COX-2	COX-1	17709(Tax:10090)	17708(Tax:10090)	Gene	Gene	_|amod|START_ENTITY _|dep|isothiazoles isothiazoles|dep|END_ENTITY	Diaryl-dithiolanes_and _ - isothiazoles : COX-1 / COX-2 and 5-LOX-inhibitory , * OH scavenging and anti-adhesive activities .
20812280	0	COX-2	87,92	COX-1	80,85	COX-2	COX-1	4513	4512	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Effect of isolated fractions of Harpagophytum procumbens D.C. -LRB- devil 's claw -RRB- on COX-1 , COX-2 activity and nitric_oxide production on whole-blood assay .
21035466	0	COX-2	10,15	COX-1	31,36	COX-2	COX-1	5743	4512	Gene	Gene	dominates|nsubj|START_ENTITY dominates|dobj|END_ENTITY	Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis : mechanisms of COX-2 inhibitor risk to heart_disease .
21035466	0	COX-2	81,86	COX-1	31,36	COX-2	COX-1	5743	4512	Gene	Gene	risk|compound|START_ENTITY mechanisms|nmod|risk dominates|dobj|mechanisms dominates|dobj|END_ENTITY	Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis : mechanisms of COX-2 inhibitor risk to heart_disease .
21629780	0	COX-2	78,83	COX-1	39,44	COX-2	COX-1	17709(Tax:10090)	17708(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY unaffected|nmod|inhibition END_ENTITY|dep|unaffected	Thrombosis is reduced by inhibition of COX-1 , but unaffected by inhibition of COX-2 , in an acute model of platelet activation in the mouse .
22219191	0	COX-2	13,18	COX-1	49,54	COX-2	COX-1	5743	4512	Gene	Gene	enzyme|compound|START_ENTITY Induction|nmod|enzyme Induction|nmod|expression expression|compound|END_ENTITY	Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide -LRB- LPS -RRB- control prostaglandin_E2 production in astrocytes .
23777557	0	COX-2	149,154	COX-1	143,148	COX-2	COX-1	854622(Tax:4932)	854598(Tax:4932)	Gene	Gene	active|amod|START_ENTITY sites|amod|active sites|compound|END_ENTITY	Dual evaluation of some novel 2-amino-substituted_coumarinylthiazoles as anti-inflammatory-antimicrobial agents and their docking studies with COX-1 / COX-2 active sites .
23874970	0	COX-2	119,124	COX-1	23,28	COX-2	COX-1	17709(Tax:10090)	17708(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY sites|nmod|expression reveals|dobj|sites drives|xcomp|reveals drives|nsubj|END_ENTITY	LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression .
25484897	0	COX-2	99,104	COX-1	93,98	COX-2	COX-1	4513	4512	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Binding Energy Calculation of Patchouli Alcohol Isomer Cyclooxygenase Complexes Suggested as COX-1 / COX-2 Selective Inhibitor .
25866240	0	COX-2	126,131	COX-1	120,125	COX-2	COX-1	4513	4512	Gene	Gene	inhibitors|nsubj|START_ENTITY Design|parataxis|inhibitors Design|appos|evaluation evaluation|nmod|derivatives derivatives|nmod|END_ENTITY	Design , synthesis , biological evaluation and molecular modeling of dihydropyrazole_sulfonamide derivatives as potential COX-1 / COX-2 inhibitors .
27086708	0	COX-2	26,31	COX-1	20,25	COX-2	COX-1	4513	4512	Gene	Gene	lornoxicam|compound|START_ENTITY lornoxicam|nmod|END_ENTITY	Tolerability of the COX-1 / COX-2 inhibitor lornoxicam in the treatment of acute and rheumatic_pain .
7857975	0	COX-2	64,69	COX-1	42,47	COX-2	COX-1	5743	5742	Gene	Gene	constitutive|appos|START_ENTITY constitutive|appos|END_ENTITY	Differential measurement of constitutive -LRB- COX-1 -RRB- and inducible -LRB- COX-2 -RRB- cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays .
9083488	0	COX-2	98,103	COX-1	104,109	COX-2	COX-1	4513	4512	Gene	Gene	Effect|nmod|START_ENTITY Effect|parataxis|END_ENTITY	Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2 / COX-1 selectivity .
9893042	0	COX-2	86,91	COX-1	113,118	COX-2	COX-1	4513	4512	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Specific NF-kappaB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells .
11577463	0	COX-2	68,73	COX-2	88,93	COX-2	COX-2	4513	4513	Gene	Gene	inhibitor|compound|START_ENTITY aspirin|appos|inhibitor Cyclooxygenase|dep|aspirin Cyclooxygenase|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
11577463	0	COX-2	88,93	COX-2	68,73	COX-2	COX-2	4513	4513	Gene	Gene	-RSB-|compound|START_ENTITY Cyclooxygenase|nmod|-RSB- Cyclooxygenase|dep|aspirin aspirin|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Cyclooxygenase -LRB- COX -RRB- -2 selective inhibitors : aspirin , a dual COX-1 / COX-2 inhibitor , to COX-2 selective inhibitors -RSB- .
18186150	0	COX-2	0,5	COX-2	41,46	COX-2	COX-2	4513	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	COX-2 and p53 in human sinonasal_cancer : COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure .
18186150	0	COX-2	41,46	COX-2	0,5	COX-2	COX-2	4513	4513	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	COX-2 and p53 in human sinonasal_cancer : COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure .
22843946	0	COX-2	20,25	COX-2	58,63	COX-2	COX-2	5743	5743	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Association between COX-2 expression and effectiveness of COX-2 inhibitors in a phase II trial in patients with metastatic colorectal_adenocarcinoma .
22843946	0	COX-2	58,63	COX-2	20,25	COX-2	COX-2	5743	5743	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Association between COX-2 expression and effectiveness of COX-2 inhibitors in a phase II trial in patients with metastatic colorectal_adenocarcinoma .
12234923	0	COX-2	13,18	CREB	72,76	COX-2	CREB	17709(Tax:10090)	12912(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY regulated|nsubjpass|Induction regulated|nmod|signals signals|compound|END_ENTITY	Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals .
17559081	0	COX-2	38,43	CREB	59,63	COX-2	CREB	26198(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Ang_II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells .
18355441	0	COX-2	15,20	CREB	68,72	COX-2	CREB	4513	1385	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nmod|monocytes monocytes|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB .
21268077	0	COX-2	27,32	CREB	137,141	COX-2	CREB	5743	1385	Gene	Gene	modulates|dep|START_ENTITY modulates|parataxis|signaling signaling|compound|END_ENTITY	Enterovirus 71 modulates a COX-2 / PGE2/cAMP-dependent viral replication in human neuroblastoma cells : role of the c-Src/EGFR/p42 / p44_MAPK / CREB signaling pathway .
25423567	0	COX-2	29,34	CREB	99,103	COX-2	CREB	5743	1385	Gene	Gene	Expression|compound|START_ENTITY cGMP|dobj|Expression cGMP|nmod|Pathway Pathway|compound|END_ENTITY	Nitric_Oxide and cGMP Induce COX-2 Expression and PGE2 Production in Human Granulosa Cells Through CREB Signaling Pathway .
12089724	0	COX-2	18,23	Cyclooxygenase-2	0,16	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression by immunohistochemistry in glioblastoma multiforme .
12504032	0	COX-2	18,23	Cyclooxygenase-2	0,16	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression in locally advanced cervical_cancer patients undergoing chemoradiation plus surgery .
14633140	0	COX-2	18,23	Cyclooxygenase-2	0,16	COX-2	Cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition limits abnormal COX-2 expression and progressive injury_in_the_remnant_kidney .
16557596	0	COX-2	18,23	Cyclooxygenase-2	0,16	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression is an independent predictor of prostate_cancer recurrence .
17354612	0	COX-2	18,23	Cyclooxygenase-2	0,16	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human endometrial_carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy .
19031117	0	COX-2	57,62	Cyclooxygenase-2	0,16	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Cyclooxygenase-2 -LRB- COX-2 -RRB- in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal_cancers .
23777936	0	COX-2	31,36	Cyclooxygenase-2	13,29	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Influence of Cyclooxygenase-2 -LRB- COX-2 -RRB- gene promoter-1195 and allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- polymorphisms on allograft outcome in Hispanic_kidney_transplant_recipients .
23973990	0	COX-2	18,23	Cyclooxygenase-2	0,16	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition constrains indoleamine_2 ,3 - dioxygenase_1 -LRB- IDO1 -RRB- activity in acute_myeloid_leukaemia cells .
25683901	0	COX-2	52,57	Cyclooxygenase-2	34,50	COX-2	Cyclooxygenase-2	5743	5743	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Immunohistochemical Expression of Cyclooxygenase-2 -LRB- COX-2 -RRB- in Feline Endometrial_Adenocarcinoma and in Normal and Hyperplastic Endometria .
16277613	0	COX-2	18,23	Cyclooxygenase_2	0,16	COX-2	Cyclooxygenase 2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Cyclooxygenase_2 -LRB- COX-2 -RRB- inhibition increases the inflammatory response in the brain during systemic immune stimuli .
24669166	0	COX-2	26,31	Cyclooxygenase_2	8,24	COX-2	Cyclooxygenase 2	5743	5743	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Cyclooxygenase_2 -LRB- COX-2 -RRB- in Prognosis of Breast_Cancer .
21071513	0	COX-2	52,57	D-dopachrome_tautomerase	18,42	COX-2	D-dopachrome tautomerase	4513	1652	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	The MIF homologue D-dopachrome_tautomerase promotes COX-2 expression through b-catenin-dependent and - independent mechanisms .
21335003	0	COX-2	33,38	E-cadherin	15,25	COX-2	E-cadherin	4513	999	Gene	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|VEGF VEGF|compound|END_ENTITY	Correlation of E-cadherin , VEGF , COX-2 expression to prognostic parameters in papillary_thyroid_carcinoma .
23670240	0	COX-2	0,5	E-cadherin	16,26	COX-2	E-cadherin	5743	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	COX-2 regulates E-cadherin expression through the NF-kB/Snail signaling pathway in gastric_cancer .
22251572	0	COX-2	33,38	EC-SOD	0,6	COX-2	EC-SOD	17709(Tax:10090)	20657(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	EC-SOD induces apoptosis through COX-2 and galectin-7 in the epidermis .
12472883	0	COX-2	13,18	ERK1/2	100,106	COX-2	ERK1/2	26198(Tax:10116)	50689;116590	Gene	Gene	gliosis|amod|START_ENTITY Induction|nmod|gliosis dependent|nsubj|Induction dependent|nmod|END_ENTITY	Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling .
18958425	0	COX-2	44,49	ERK1/2	64,70	COX-2	ERK1/2	4513	5595;5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of lysophosphatidic_acid-induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells .
22210040	0	COX-2	13,18	ERK1/2	80,86	COX-2	ERK1/2	4513	5595;5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	Acid-induced COX-2 expression and prostaglandin_E2 production via activation of ERK1/2 and p38 MAPK in cultured feline esophageal smooth muscle cells .
24924779	0	COX-2	81,86	ERK1/2	51,57	COX-2	ERK1/2	5743	5595;5594	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Eckols reduce dental_pulp_inflammation through the ERK1/2 pathway independent of COX-2 inhibition .
22517768	0	COX-2	105,110	Epidermal_growth_factor_receptor	0,32	COX-2	Epidermal growth factor receptor	4513	1956	Gene	Gene	expression|compound|START_ENTITY required|nmod|expression required|nsubjpass|transactivation transactivation|compound|END_ENTITY	Epidermal_growth_factor_receptor transactivation is required for proteinase-activated_receptor-2-induced COX-2 expression in intestinal epithelial cells .
19534809	0	COX-2	21,26	Erk1/2	42,48	COX-2	Erk1/2	4513	5595;5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Deoxycholate induces COX-2 expression via Erk1/2 - , p38-MAPK and AP-1-dependent mechanisms in esophageal_cancer cells .
23886206	0	COX-2	96,101	GM-CSF	129,135	COX-2	GM-CSF	17709(Tax:10090)	12981(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|acl|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
17098744	0	COX-2	32,37	Galpha12	0,8	COX-2	Galpha12	19225(Tax:10090)	14673(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY regulates|dobj|induction regulates|nsubj|END_ENTITY	Galpha12 specifically regulates COX-2 induction by sphingosine_1-phosphate .
15068324	0	COX-2	13,18	HER-2	0,5	COX-2	HER-2	4513	2064	Gene	Gene	status|amod|START_ENTITY status|compound|END_ENTITY	HER-2 , EGFR , COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung_cancer .
15842638	0	COX-2	0,5	HER-2	49,54	COX-2	COX-2	4513	4513	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	COX-2 expression in DCIS : correlation with VEGF , HER-2 / neu , prognostic molecular markers and clinicopathological features .
18992713	0	COX-2	23,28	HO-1	57,61	COX-2	HO-1	26198(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain .
27075590	0	COX-2	59,64	HSP90	0,5	COX-2	HSP90	5743	3320	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal_Cancer_Cells .
17383427	0	COX-2	89,94	HuR	51,54	COX-2	HuR	5743	1994	Gene	Gene	translation|compound|START_ENTITY fate|nmod|translation determines|dobj|fate determines|nsubj|antagonism antagonism|nmod|END_ENTITY	Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation .
18468781	0	COX-2	69,74	HuR	36,39	COX-2	HuR	4513	1994	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of ELAV-like protein HuR is associated with increased COX-2 expression in atrophy , high-grade_prostatic_intraepithelial_neoplasia , and incidental_prostate_cancer in cystoprostatectomies .
18705402	0	COX-2	93,98	HuR	67,70	COX-2	HuR	5743	1994	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of embryonic_lethal_abnormal_vision -LRB- ELAV -RRB- - like protein HuR and cyclooxygenase-2 -LRB- COX-2 -RRB- in Ewing_sarcoma .
19917608	0	COX-2	84,89	HuR	8,11	COX-2	HuR	5743	1994	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression Role|nmod|regulation Role|nmod|END_ENTITY	Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT .
22049153	0	COX-2	64,69	HuR	26,29	COX-2	HuR	4513	1994	Gene	Gene	microRNA-16|nmod|START_ENTITY inhibits|dobj|microRNA-16 inhibits|nsubj|END_ENTITY	The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2 .
25653183	0	COX-2	77,82	HuR	0,3	COX-2	HuR	17709(Tax:10090)	15568(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY mediates|nmod|expression mediates|nsubj|END_ENTITY	HuR mediates the synergistic effects of angiotensin_II and IL-1b on vascular COX-2 expression and cell migration .
26498465	0	COX-2	73,78	HuR	46,49	COX-2	HuR	5743	1994	Gene	Gene	Receptor|appos|START_ENTITY Receptor|appos|END_ENTITY	Clinical Significance of Hu-Antigen Receptor -LRB- HuR -RRB- and Cyclooxygenase-2 -LRB- COX-2 -RRB- Expression in Human Malignant and Benign Thyroid Lesions .
24556222	0	COX-2	39,44	ICAM-1	52,58	COX-2	ICAM-1	17709(Tax:10090)	15894(Tax:10090)	Gene	Gene	cytokines|compound|START_ENTITY cytokines|dep|END_ENTITY	Tinospora cordifolia extract modulates COX-2 , iNOS , ICAM-1 , pro-inflammatory cytokines and redox status in murine model of asthma .
16457848	0	COX-2	0,5	IL-11	14,19	COX-2	IL-11	5743	3589	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	COX-2 induces IL-11 production in human breast_cancer cells .
21310944	0	COX-2	19,24	IL-1b	68,73	COX-2	IL-1b	5743	3553	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|autoamplification autoamplification|compound|END_ENTITY	Macrophages induce COX-2 expression in breast_cancer cells : role of IL-1b autoamplification .
21394197	0	COX-2	17,22	IL-1b	0,5	COX-2	IL-1b	26198(Tax:10116)	24494(Tax:10116)	Gene	Gene	dependent|amod|START_ENTITY synthesis|amod|dependent stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	IL-1b stimulates COX-2 dependent PGE synthesis and CGRP release in rat trigeminal ganglia cells .
23781123	0	COX-2	167,172	IL-1b	174,179	COX-2	IL-1b	17709(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Biphasic modulation of NOS expression , protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock : downstream regulation of COX-2 , IL-1b , TNF-a , IL-6 , and HMGB1 expression .
23886206	0	COX-2	96,101	IL-1b	103,108	COX-2	IL-1b	17709(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24133591	0	COX-2	47,52	IL-1b	65,70	COX-2	IL-1b	5743	3553	Gene	Gene	expression|nmod|START_ENTITY signal|dobj|expression signal|nmod|END_ENTITY	MAPK/ERK signal pathway involved expression of COX-2 and VEGF by IL-1b induced in human endometriosis stromal cells in vitro .
25237168	0	COX-2	103,108	IL-1b	128,133	COX-2	IL-1b	5743	3553	Gene	Gene	production|compound|START_ENTITY prostaglandin_E2|nmod|production upregulates|dobj|prostaglandin_E2 upregulates|nmod|END_ENTITY	Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin_E2 via COX-2 production without IL-1b and TNF-a .
25531650	0	COX-2	77,82	IL-1b	31,36	COX-2	IL-1b	26198(Tax:10116)	24494(Tax:10116)	Gene	Gene	RANK/RANKL|nmod:npmod|START_ENTITY RANK/RANKL|dep|END_ENTITY	Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
25806956	0	COX-2	89,94	IL-1b	43,48	COX-2	IL-1b	4513	3553	Gene	Gene	RANK/RANKL|appos|START_ENTITY RANK/RANKL|compound|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
26560040	0	COX-2	93,98	IL-1b	66,71	COX-2	IL-1b	4513	3553	Gene	Gene	pathway|compound|START_ENTITY IL-1_type_I_receptor|dep|pathway E-prostanoid|parataxis|IL-1_type_I_receptor E-prostanoid|dep|levels levels|nmod|END_ENTITY	Low E-prostanoid 2 receptor levels and deficient induction of the IL-1b / IL-1_type_I_receptor / COX-2 pathway : Vicious circle in patients with aspirin-exacerbated_respiratory_disease .
10960082	0	COX-2	13,18	IL-1beta	46,54	COX-2	IL-1beta	17709(Tax:10090)	16176(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY biosynthesis|nsubj|Induction biosynthesis|advcl|mediated mediated|nsubjpass|END_ENTITY	Induction of COX-2 and PGE -LRB- 2 -RRB- biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes .
17234889	0	COX-2	100,105	IL-1beta	0,8	COX-2	IL-1beta	26198(Tax:10116)	24494(Tax:10116)	Gene	Gene	induction|compound|START_ENTITY involvement|nmod|induction proliferation|dep|involvement inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system : involvement of COX-2 and iNOS induction in muscularis resident macrophages .
17719733	0	COX-2	44,49	IL-1beta	34,42	COX-2	IL-1beta	808233(Tax:9986)	100008990(Tax:9986)	Gene	Gene	MCP-1|amod|START_ENTITY MCP-1|amod|END_ENTITY	The time-dependent expressions of IL-1beta , COX-2 , MCP-1 mRNA in skin wounds of rabbits .
9266823	0	COX-2	72,77	IL-1beta	97,105	COX-2	IL-1beta	4513	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta .
16574063	0	COX-2	15,20	IL-4	0,4	COX-2	IL-4	4513	3565	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	IL-4 regulates COX-2 and PGE2 production in human non-small_cell_lung_cancer .
12608645	0	COX-2	23,28	IL-6	90,94	COX-2	IL-6	4513	3569	Gene	Gene	expression|compound|START_ENTITY expression|dep|evidence evidence|dep|COX-2-dependent COX-2-dependent|nsubj|synthesis synthesis|compound|END_ENTITY	CD40 ligation triggers COX-2 expression in endothelial cells : evidence that CD40-mediated IL-6 synthesis is COX-2-dependent .
19892012	0	COX-2	13,18	IL-6	26,30	COX-2	IL-6	5743	3569	Gene	Gene	PGE|compound|START_ENTITY Induction|nmod|PGE Induction|parataxis|crucial crucial|nsubj|END_ENTITY	Induction of COX-2 / PGE -LRB- 2 -RRB- / IL-6 is crucial for cigarette_smoke_extract-induced airway_inflammation : Role of TLR4-dependent NADPH oxidase activation .
23886206	0	COX-2	96,101	IL-6	110,114	COX-2	IL-6	17709(Tax:10090)	16193(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
25201048	0	COX-2	33,38	IL-6	60,64	COX-2	IL-6	5743	3569	Gene	Gene	expression|compound|START_ENTITY expression|dep|secretion secretion|compound|END_ENTITY	Sphingosine-1-phosphate mediates COX-2 expression and PGE2 / IL-6 secretion via c-Src-dependent AP-1 activation .
25872337	0	COX-2	37,42	INK4a	29,34	COX-2	INK4a	4513	1029	Gene	Gene	survivin|amod|START_ENTITY survivin|appos|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
25872337	0	COX-2	37,42	INK4a	29,34	COX-2	INK4a	4513	1029	Gene	Gene	survivin|amod|START_ENTITY survivin|appos|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
25038765	0	COX-2	88,93	Interleukin-17	0,14	COX-2	Interleukin-17	5743	3605	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2 / PGE2 Pathway in the Cancer Cells .
17065197	0	COX-2	36,41	JNK1	0,4	COX-2	JNK1	5743	5599	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	JNK1 , but not JNK2 , is required for COX-2 induction by nickel compounds .
23617728	0	COX-2	55,60	KAI-1	83,88	COX-2	KAI-1	17709(Tax:10090)	12521(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Papillary_carcinoma of the thyroid : high expression of COX-2 and low expression of KAI-1 / CD82 are associated with increased tumor invasiveness .
17945188	0	COX-2	15,20	Lef1	0,4	COX-2	Lef1	17709(Tax:10090)	16842(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Lef1 regulates COX-2 transcription in chondrocytes .
19846662	0	COX-2	71,76	MBP-1	0,5	COX-2	MBP-1	5743	4153	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	MBP-1 suppresses growth and metastasis of gastric_cancer cells through COX-2 .
25806956	0	COX-2	89,94	MMP-2	75,80	COX-2	MMP-2	4513	4313	Gene	Gene	RANK/RANKL|appos|START_ENTITY RANK/RANKL|compound|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
23790336	0	COX-2	0,5	MMP-7	7,12	COX-2	MMP-7	4513	4316	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	COX-2 , MMP-7 expression in oral_lichen_planus_and_oral_squamous_cell_carcinoma .
24704993	0	COX-2	24,29	MMP-7	0,5	COX-2	MMP-7	5743	4316	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung_adenocarcinoma cells .
20195390	0	COX-2	77,82	MT1-MMP	34,41	COX-2	MT1-MMP	17709(Tax:10090)	17387(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway .
22971618	0	COX-2	111,116	MT1-MMP	89,96	COX-2	MT1-MMP	4513	4323	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells .
11062012	0	COX-2	22,27	NF-kappaB	94,103	COX-2	NF-kappaB	4513	4790	Gene	Gene	induction|nmod|START_ENTITY involve|nsubj|induction involve|dobj|activation activation|nmod|END_ENTITY	Ceramide induction of COX-2 and PGE -LRB- 2 -RRB- in pulmonary A549 cells does not involve activation of NF-kappaB .
12807725	0	COX-2	195,200	NF-kappaB	68,77	COX-2	NF-kappaB	4513	4790	Gene	Gene	suppression|nmod|START_ENTITY correlation|nmod|suppression cigarette|dep|correlation cigarette|acl|smoke-induced smoke-induced|dobj|activation activation|amod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
15067740	0	COX-2	84,89	NF-kappaB	56,65	COX-2	NF-kappaB	5743	4790	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid_arthritis synovial fibroblasts -RSB- .
15655349	0	COX-2	45,50	NF-kappaB	95,104	COX-2	NF-kappaB	5743	4790	Gene	Gene	expression|appos|START_ENTITY expression|nmod|nuclear_factor-kappa_B nuclear_factor-kappa_B|appos|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
16380122	0	COX-2	59,64	NF-kappaB	119,128	COX-2	NF-kappaB	5743	4790	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|dep|END_ENTITY	Hirsutenone inhibits phorbol_ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells : NF-kappaB as a potential molecular target .
16474181	0	COX-2	57,62	NF-kappaB	81,90	COX-2	NF-kappaB	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Resveratrol inhibits phorbol_ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity .
18314621	0	COX-2	91,96	NF-kappaB	1,10	COX-2	NF-kappaB	5743	4790	Gene	Gene	-RSB-|compound|START_ENTITY impact|nmod|-RSB- expression|dep|impact expression|amod|END_ENTITY	-LSB- NF-kappaB subunit p65/RelA expression in ovarian_carcinoma : prognostic impact and link to COX-2 overexpression -RSB- .
18761708	0	COX-2	20,25	NF-kappaB	85,94	COX-2	NF-kappaB	5743	4790	Gene	Gene	expression|compound|START_ENTITY expression|acl|suppressing suppressing|dobj|activity activity|nmod|END_ENTITY	Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia .
19393729	0	COX-2	63,68	NF-kappaB	122,131	COX-2	NF-kappaB	17709(Tax:10090)	18033(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|mediated mediated|nmod|regulation regulation|amod|END_ENTITY	Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2 , TNF-alpha and iNOS expression , which is mediated by NF-kappaB regulation , in RAW264 .7 cells .
19494233	0	COX-2	29,34	NF-kappaB	126,135	COX-2	NF-kappaB	5743	4790	Gene	Gene	expression|compound|START_ENTITY stimulate|dobj|expression stimulate|nmod|pathway pathway|amod|END_ENTITY	Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced , calpain-dependent , NF-kappaB pathway .
19717552	0	COX-2	32,37	NF-kappaB	91,100	COX-2	NF-kappaB	5743	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR , PDGFR/PI3K/Akt / NF-kappaB pathway and p300 in tracheal smooth muscle cells .
19885014	0	COX-2	26,31	NF-kappaB	66,75	COX-2	NF-kappaB	4513	4790	Gene	Gene	Expression|compound|START_ENTITY Down-regulate|dobj|Expression Down-regulate|nmod|Suppression Suppression|nmod|Activity Activity|amod|END_ENTITY	DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells .
9266823	0	COX-2	72,77	NF-kappaB	28,37	COX-2	NF-kappaB	4513	4790	Gene	Gene	expression|compound|START_ENTITY control|nmod|expression Evidence|nmod|control Evidence|nmod|END_ENTITY	Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta .
24657343	0	COX-2	16,21	NFAT2	0,5	COX-2	NFAT2	4513	4772	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NFAT2 regulates COX-2 expression and modulates the integrin repertoire in endothelial cells at the crossroads of angiogenesis and inflammation .
12349897	0	COX-2	124,129	NFkappaB	149,157	COX-2	NFkappaB	5743	4790	Gene	Gene	transcription|appos|START_ENTITY transcription|nmod|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
25872337	0	COX-2	37,42	P16	25,28	COX-2	P16	4513	1029	Gene	Gene	survivin|amod|START_ENTITY survivin|appos|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
25872337	0	COX-2	37,42	P16	25,28	COX-2	P16	4513	1029	Gene	Gene	survivin|amod|START_ENTITY survivin|appos|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
21388279	0	COX-2	50,55	P2Y6_receptor	15,28	COX-2	P2Y6 receptor	4513	5031	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Involvement of P2Y6_receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes .
16336951	0	COX-2	15,20	P38	54,57	COX-2	P38	5743	5594	Gene	Gene	START_ENTITY|nmod|angiogenesis angiogenesis|nmod|END_ENTITY	Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells .
18657608	0	COX-2	18,23	P38	0,3	COX-2	P38	5743	1432	Gene	Gene	expression|compound|START_ENTITY mediates|dobj|expression mediates|nsubj|MAPK MAPK|compound|END_ENTITY	P38 MAPK mediates COX-2 gene expression by corticosterone in cardiomyocytes .
19861252	0	COX-2	27,32	P38MAPK	1,8	COX-2	P38MAPK	17709(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- P38MAPK pathway regulates COX-2 and caspase-3 expression in a mouse model of Parkinson_disease -RSB- .
23907425	0	COX-2	11,16	P53	163,166	COX-2	P53	5743	7157	Gene	Gene	factors|amod|START_ENTITY Changes|nmod|factors associated|nsubjpass|Changes associated|nmod|downregulation downregulation|nmod|gene gene|compound|END_ENTITY	Changes in COX-2 and oxidative damage factors during differentiation of human mesenchymal stem cells to hepatocyte-like cells is associated with downregulation of P53 gene .
16000874	0	COX-2	0,5	PI-3K	44,49	COX-2	PI-3K	5743	5293	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	COX-2 inhibits anoikis by activation of the PI-3K / Akt pathway in human bladder_cancer cells .
21292998	0	COX-2	48,53	PKD	69,72	COX-2	PKD	5743	5587	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	TNF-a potentiates lysophosphatidic_acid-induced COX-2 expression via PKD in human colonic myofibroblasts .
18615182	0	COX-2	48,53	PPAR-gamma	12,22	COX-2	PPAR-gamma	4513	5468	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of PPAR-gamma and Its Interaction with COX-2 in Pancreatic_Cancer .
19627000	0	COX-2	32,37	PPAR-gamma	20,30	COX-2	PPAR-gamma	4513	5468	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|expressions expressions|nmod|END_ENTITY	-LSB- The expressions of PPAR-gamma , COX-2 in the lesions of patients with condyloma_acuminatum and bowenoid_papulosis -RSB- .
17459764	0	COX-2	65,70	PPARgamma	75,84	COX-2	PPARgamma	5743	5468	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	n-3 and n-6 polyunsaturated_fatty_acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells .
17669705	0	COX-2	77,82	PPARgamma	0,9	COX-2	PPARgamma	26198(Tax:10116)	25664(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY down-regulation|nmod|expression osteogenesis|nmod|down-regulation inhibits|dobj|osteogenesis inhibits|nsubj|END_ENTITY	PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats .
25770423	0	COX-2	19,24	PTEN	11,15	COX-2	PTEN	4513	5728	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization .
17578436	0	COX-2	69,74	PTGS2	81,86	COX-2	PTGS2	5743	5743	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of functional gene variants in the regulatory regions of COX-2 gene -LRB- PTGS2 -RRB- with nonmelanoma_skin_cancer after organ transplantation .
18085997	0	COX-2	39,44	PTGS2	51,56	COX-2	PTGS2	4513	5743	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Pyrosequencing of polymorphisms in the COX-2 gene -LRB- PTGS2 -RRB- with reported clinical relevance .
20378913	0	COX-2	41,46	PTGS2	47,52	COX-2	PTGS2	4513	5743	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The -LRB- -765 _ G _ > _ C -RRB- promoter variant of the COX-2 / PTGS2 gene is associated with a lower risk for end-stage hip and knee_osteoarthritis .
25532119	0	COX-2	33,38	PTPRJ	24,29	COX-2	PTPRJ	808233(Tax:9986)	100347798(Tax:9986)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Regulated Expression of PTPRJ by COX-2 / PGE2 Axis in Endothelial Cells .
19794144	0	COX-2	52,57	Protein_kinase_D	0,16	COX-2	Protein kinase D	4513	5587	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Protein_kinase_D mediates synergistic expression of COX-2 induced by TNF - -LCB- alpha -RCB- and bradykinin in human colonic myofibroblasts .
16612568	0	COX-2	44,49	RANKL	34,39	COX-2	RANKL	4513	8600	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Substance_P stimulates release of RANKL via COX-2 expression in human dental pulp cells .
25943190	0	COX-2	144,149	RelB	48,52	COX-2	RelB	4513	5971	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Decreased expression of the NF-kB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression .
25943190	0	COX-2	144,149	RelB	48,52	COX-2	RelB	4513	5971	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Decreased expression of the NF-kB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression .
17023559	0	COX-2	46,51	S100B	0,5	COX-2	S100B	4513	6285	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	S100B binding to RAGE in microglia stimulates COX-2 expression .
24064301	0	COX-2	38,43	S1P_receptor_2	78,92	COX-2	S1P receptor 2	26198(Tax:10116)	29415(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induces COX-2 expression and PGE2 formation via S1P_receptor_2 in renal_mesangial_cells .
25320180	0	COX-2	15,20	SIRT6	0,5	COX-2	SIRT6	4513	51548	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin_Cancer .
25544576	0	COX-2	17,22	TGF-b	0,5	COX-2	TGF-b	5743	7040	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells .
24098479	0	COX-2	21,26	TGF-b1	0,6	COX-2	TGF-b1	5743	7040	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	TGF-b1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung_cancer A549 cells , which is involved in fibrotic response to TGF-b1 .
24098479	0	COX-2	21,26	TGF-b1	152,158	COX-2	TGF-b1	5743	7040	Gene	Gene	expression|compound|START_ENTITY expression|acl|leading leading|xcomp|decrease decrease|nmod|cells cells|acl:relcl|involved involved|nmod|END_ENTITY	TGF-b1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung_cancer A549 cells , which is involved in fibrotic response to TGF-b1 .
24712567	0	COX-2	15,20	TGF-b1	0,6	COX-2	TGF-b1	5743	7040	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b1 induces COX-2 expression and PGE2 production in human granulosa cells through Smad signaling pathways .
16820791	0	COX-2	18,23	TGF-beta1	0,9	COX-2	TGF-beta1	5743	7040	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells .
20375691	0	COX-2	33,38	TGF-beta1	0,9	COX-2	TGF-beta1	4513	7040	Gene	Gene	inhibition|nmod|START_ENTITY reverses|dobj|inhibition reverses|nsubj|END_ENTITY	TGF-beta1 reverses inhibition of COX-2 with NS398 and increases invasion in prostate_cancer cells .
23781123	0	COX-2	167,172	TNF-a	181,186	COX-2	TNF-a	17709(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Biphasic modulation of NOS expression , protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock : downstream regulation of COX-2 , IL-1b , TNF-a , IL-6 , and HMGB1 expression .
23886206	0	COX-2	96,101	TNF-a	83,88	COX-2	TNF-a	17709(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|compound|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
10810453	0	COX-2	45,50	TNF-alpha	134,143	COX-2	TNF-alpha	5743	7124	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability regulation|appos|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
12349897	0	COX-2	124,129	TNF-alpha	29,38	COX-2	TNF-alpha	5743	7124	Gene	Gene	transcription|appos|START_ENTITY activation|nmod|transcription mediated|nmod|activation induced|ccomp|mediated alpha|acl|induced alpha|appos|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
12890694	0	COX-2	66,71	TNF-alpha	117,126	COX-2	TNF-alpha	19225(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY mediates|dobj|induction mediates|nmod|END_ENTITY	The sphingosine_kinase_1 / sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha .
17117478	0	COX-2	216,221	TNF-alpha	164,173	COX-2	TNF-alpha	17709(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY macrophages|nmod|induction suppressing|nmod|macrophages suppressing|dobj|release release|amod|END_ENTITY	Corticotropin releasing factor receptor 1 -LRB- CRF1 -RRB- and CRF2 agonists exert an anti-inflammatory effect during the early phase of inflammation suppressing LPS-induced TNF-alpha release from macrophages via induction of COX-2 and PGE2 .
19393729	0	COX-2	63,68	TNF-alpha	70,79	COX-2	TNF-alpha	17709(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2 , TNF-alpha and iNOS expression , which is mediated by NF-kappaB regulation , in RAW264 .7 cells .
20122965	0	COX-2	43,48	TNF-alpha	12,21	COX-2	TNF-alpha	19225(Tax:10090)	21926(Tax:10090)	Gene	Gene	upregulation|compound|START_ENTITY signaling|nmod|upregulation END_ENTITY|acl|signaling	The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive_decline induced by beta-amyloid peptide .
14592548	0	COX-2	25,30	TNFalpha	0,8	COX-2	TNFalpha	26198(Tax:10116)	24835(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TNFalpha regulates renal COX-2 in the rat thick ascending limb -LRB- TAL -RRB- .
25218028	0	COX-2	0,5	ULBP-1	65,71	COX-2	ULBP-1	4513	80329	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	COX-2 - and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon_cancer cells .
12881220	0	COX-2	34,39	VEGF	81,85	COX-2	VEGF	4513	7422	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells : role of VEGF .
15358633	0	COX-2	76,81	VEGF	17,21	COX-2	VEGF	5743	7422	Gene	Gene	-2|compound|START_ENTITY pathway|compound|-2 modulating|dobj|pathway cells|acl|modulating reduce|nmod|cells reduce|dobj|expression expression|amod|END_ENTITY	n-3 PUFAs reduce VEGF expression in human colon_cancer cells modulating the COX-2 / PGE2 induced ERK-1_and _ -2 and HIF-1alpha induction pathway .
15842638	0	COX-2	0,5	VEGF	43,47	COX-2	VEGF	4513	7422	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|HER-2 HER-2|compound|END_ENTITY	COX-2 expression in DCIS : correlation with VEGF , HER-2 / neu , prognostic molecular markers and clinicopathological features .
15968728	2	COX-2	457,462	VEGF	464,468	COX-2	VEGF	5743	7422	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	METHODS : Sixty-four gallbladder_carcinoma specimens were evaluated for COX-2 , VEGF expression by immunohistochemical methods .
16806797	0	COX-2	44,49	VEGF	25,29	COX-2	VEGF	5743	7422	Gene	Gene	treatment|compound|START_ENTITY circulating|nmod|treatment circulating|dobj|levels levels|amod|END_ENTITY	Increases in circulating VEGF levels during COX-2 inhibitor treatment in breast_cancer patients .
17687613	0	COX-2	63,68	VEGF	27,31	COX-2	VEGF	5743	7422	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|expression expression|compound|END_ENTITY	Prognostic significance of VEGF expression in correlation with COX-2 , microvessel density , and clinicopathological characteristics in human gastric_carcinoma .
18093816	0	COX-2	0,5	VEGF	62,66	COX-2	VEGF	4513	7422	Gene	Gene	linked|nsubjpass|START_ENTITY linked|xcomp|END_ENTITY	COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells .
18533784	0	COX-2	0,5	VEGF	27,31	COX-2	VEGF	26198(Tax:10116)	83785(Tax:10116)	Gene	Gene	decreases|compound|START_ENTITY END_ENTITY|nsubj|decreases	COX-2 inhibition decreases VEGF expression and alveolar_bone_loss during the progression of experimental periodontitis in rats .
20398651	0	COX-2	20,25	VEGF	37,41	COX-2	VEGF	17709(Tax:10090)	22339(Tax:10090)	Gene	Gene	deletion|nmod|START_ENTITY diminishes|nsubj|deletion diminishes|dobj|production production|amod|END_ENTITY	Genetic deletion of COX-2 diminishes VEGF production in mouse retinal M ller cells .
20675158	0	COX-2	0,5	VEGF	38,42	COX-2	VEGF	5743	7422	Gene	Gene	over-expression|compound|START_ENTITY correlates|nsubj|over-expression correlates|nmod|angiogenesis angiogenesis|compound|END_ENTITY	COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer .
21335003	0	COX-2	33,38	VEGF	27,31	COX-2	VEGF	4513	7422	Gene	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of E-cadherin , VEGF , COX-2 expression to prognostic parameters in papillary_thyroid_carcinoma .
23114124	0	COX-2	12,17	VEGF	56,60	COX-2	VEGF	4513	7422	Gene	Gene	celecoxib|compound|START_ENTITY celecoxib|nmod|expressions expressions|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effects of COX-2 inhibitor celecoxib on expressions of VEGF , b-FGF and TGF-b mRNA in acute_leukemia cells -RSB- .
24284961	0	COX-2	109,114	VEGF	73,77	COX-2	VEGF	4513	7422	Gene	Gene	expression|compound|START_ENTITY upregulation|nmod|expression production|nmod|upregulation production|amod|END_ENTITY	Apurinic/apyrimidinic _ endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal_cancer tissues .
26675577	0	COX-2	102,107	VEGF	73,77	COX-2	VEGF	5743	7422	Gene	Gene	activity|nmod|START_ENTITY MMP-9|appos|activity MMP-9|compound|END_ENTITY	-LSB- Targeted interruption of COX-2 gene by siRNA inhibits the expression of VEGF , MMP-9 , the activity of COX-2 and stimulates the apoptosis in eutopic , ectopic endometrial stromal cells of women with endometriosis -RSB- .
26675577	0	COX-2	26,31	VEGF	73,77	COX-2	VEGF	5743	7422	Gene	Gene	gene|compound|START_ENTITY interruption|nmod|gene inhibits|nsubj|interruption inhibits|dobj|expression expression|nmod|MMP-9 MMP-9|compound|END_ENTITY	-LSB- Targeted interruption of COX-2 gene by siRNA inhibits the expression of VEGF , MMP-9 , the activity of COX-2 and stimulates the apoptosis in eutopic , ectopic endometrial stromal cells of women with endometriosis -RSB- .
19280060	0	COX-2	65,70	VEGF-C	27,33	COX-2	VEGF-C	5743	7424	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|expression expression|amod|END_ENTITY	Prognostic significance of VEGF-C expression in correlation with COX-2 , lymphatic microvessel density , and clinicopathologic characteristics in human non-small_cell_lung_cancer .
19825968	0	COX-2	84,89	VEGF-R3	116,123	COX-2	VEGF-R3	5743	2324	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3 / JNK/AP -1 pathway .
16290311	0	COX-2	47,52	angiopoietin-2	13,27	COX-2	angiopoietin-2	4513	285	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of angiopoietin-2 gene expression by COX-2 : a novel role for COX-2 inhibitors during hepatocarcinogenesis .
16290311	0	COX-2	71,76	angiopoietin-2	13,27	COX-2	angiopoietin-2	4513	285	Gene	Gene	inhibitors|compound|START_ENTITY role|nmod|inhibitors Induction|dep|role Induction|nmod|expression expression|amod|END_ENTITY	Induction of angiopoietin-2 gene expression by COX-2 : a novel role for COX-2 inhibitors during hepatocarcinogenesis .
12225948	0	COX-2	58,63	bradykinin	10,20	COX-2	bradykinin	4513	3827	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effect of bradykinin , TGF-beta1 , IL-1beta , and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells .
17715026	0	COX-2	46,51	c-Jun	26,31	COX-2	c-Jun	17709(Tax:10090)	16476(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson_disease -RSB- .
15256475	0	COX-2	250,255	cyclin_D1	239,248	COX-2	cyclin D1	4513	595	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Cyclooxygenase _ -LRB- COX -RRB- -2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor -LRB- NF -RRB- - kappaB by suppressing activation of IkappaBalpha kinase in human non-small_cell_lung_carcinoma : correlation with suppression of cyclin_D1 , COX-2 , and matrix_metalloproteinase-9 .
11409489	0	COX-2	90,95	cyclooxygenase-1	43,59	COX-2	cyclooxygenase-1	282023(Tax:9913)	282022(Tax:9913)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	In-vitro test system for the evaluation of cyclooxygenase-1 -LRB- COX-1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells -LRB- BAECs -RRB- .
10561943	0	COX-2	35,40	cyclooxygenase-2	17,33	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	The induction of cyclooxygenase-2 -LRB- COX-2 -RRB- in cultured endothelial cells treated with serum from preeclampsia is mediated by interleukin-6 .
10611376	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- in rat renal cortex by adrenal glucocorticoids and mineralocorticoids .
10639181	0	COX-2	48,53	cyclooxygenase-2	30,46	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Biochemically based design of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors .
10667110	0	COX-2	29,34	cyclooxygenase-2	11,27	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	-LSB- Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : importance and limitations -RSB- .
10942208	0	COX-2	75,80	cyclooxygenase-2	57,73	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Activation of NFkappaB is necessary for IL-1beta-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human_gingival_fibroblasts .
10974444	0	COX-2	52,57	cyclooxygenase-2	34,50	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Radiation induces upregulation of cyclooxygenase-2 -LRB- COX-2 -RRB- protein in PC-3 cells .
11275997	0	COX-2	96,101	cyclooxygenase-2	78,94	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tumor invasiveness and liver metastasis of colon_cancer cells correlated with cyclooxygenase-2 -LRB- COX-2 -RRB- expression and inhibited by a COX-2-selective inhibitor , etodolac .
11350912	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in hepatocellular_carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor , NS-398 .
11506952	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA in human colorectal_adenomas .
11520213	0	COX-2	89,94	cyclooxygenase-2	71,87	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere .
11563332	0	COX-2	33,38	cyclooxygenase-2	15,31	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Recognition of cyclooxygenase-2 -LRB- COX-2 -RRB- active site by NSAIDs : a computer modelling study .
11566484	0	COX-2	41,46	cyclooxygenase-2	23,39	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Specific inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- expression by dietary curcumin in HT-29 human colon_cancer cells .
11584358	0	COX-2	45,50	cyclooxygenase-2	27,43	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in human bile duct epithelial cells and bile_duct_neoplasm .
11911832	0	COX-2	28,33	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors and potential risk of cardiovascular events .
11917005	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Post-training cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition impairs memory consolidation .
12151354	0	COX-2	30,35	cyclooxygenase-2	12,28	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of cyclooxygenase-2 -LRB- COX-2 -RRB- in two different morphological stages of intestinal_polyps in APC -LRB- Delta474 -RRB- knockout mice .
12181243	0	COX-2	28,33	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Increased cyclooxygenase-2 -LRB- COX-2 -RRB- expression is associated with chemotherapy resistance and outcome in ovarian_cancer patients .
12361181	0	COX-2	66,71	cyclooxygenase-2	48,64	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Use of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : indications and complications .
12431470	0	COX-2	30,35	cyclooxygenase-2	12,28	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of cyclooxygenase-2 -LRB- COX-2 -RRB- in breast_cancer , and implications of COX-2 inhibition .
12434137	0	COX-2	29,34	cyclooxygenase-2	11,27	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Effects of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on plasma and renal renin in diabetes .
12537697	0	COX-2	97,102	cyclooxygenase-2	79,95	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the interferon regulatory factors , IRF-1 and IRF-2 , in LPS-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vivo and in vitro .
12565135	0	COX-2	102,107	cyclooxygenase-2	84,100	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Activation of the peripheral sympathetic nervous system increased the expression of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA in mouse calvaria .
14604691	0	COX-2	81,86	cyclooxygenase-2	63,79	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere .
14666698	0	COX-2	28,33	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors on prostate_cancer cell proliferation .
14747187	0	COX-2	30,35	cyclooxygenase-2	12,28	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in different sites of endometriosis and correlation with clinico-pathological parameters .
14766245	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in non-neoplastic and neoplastic vulvar_epithelial_lesions .
15026050	0	COX-2	128,133	cyclooxygenase-2	110,126	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15050635	0	COX-2	89,94	cyclooxygenase-2	71,87	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design of acyclic triaryl_olefins : a new class of potent and selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15202549	0	COX-2	63,68	cyclooxygenase-2	45,61	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	CoMFA and CoMSIA 3D QSAR studies on pimarane cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15221958	0	COX-2	86,91	cyclooxygenase-2	68,84	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fibronectin stimulates human lung_carcinoma cell growth by inducing cyclooxygenase-2 -LRB- COX-2 -RRB- expression .
15498669	0	COX-2	88,93	cyclooxygenase-2	70,86	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design and synthesis of acyclic_triaryl _ -LRB- Z -RRB- - olefins : a novel class of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15655349	0	COX-2	45,50	cyclooxygenase-2	27,43	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
15678189	0	COX-2	44,49	cyclooxygenase-2	26,42	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis of 18F-labelled cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors via Stille reaction with 4 - -LSB- 18F -RSB- fluoroiodobenzene as radiotracers for positron emission tomography -LRB- PET -RRB- .
15755648	0	COX-2	122,127	cyclooxygenase-2	104,120	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis , and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides : a novel class of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15816526	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	The effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on human prostate_cancer induced osteoblastic and osteolytic_lesions in bone .
15930344	0	COX-2	149,154	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial_adenomatous_polyposis and relationship to the -765 G _ - > _ C COX-2 polymorphism .
16044407	0	COX-2	44,49	cyclooxygenase-2	26,42	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of TPA-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin through downregulation of Akt signal transduction in human keratinocytes .
16123787	0	COX-2	44,49	cyclooxygenase-2	26,42	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The effect of a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor on the proliferation rate of retinoblastoma cell lines .
16318954	0	COX-2	39,44	cyclooxygenase-2	21,37	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Protective effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors but not non-selective cyclooxygenase -LRB- COX -RRB- - inhibitors on ethanol withdrawal-induced behavioural changes .
16445867	0	COX-2	76,81	cyclooxygenase-2	58,74	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Reduction in the risk of human breast_cancer by selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16581252	0	COX-2	80,85	cyclooxygenase-2	62,78	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Evaluation of glycolamide_esters of indomethacin as potential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16629370	0	COX-2	28,33	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors in various animal models -LRB- bicuculline , picrotoxin , maximal electroshock-induced convulsions -RRB- of epilepsy with possible mechanism of action .
16712734	0	COX-2	45,50	cyclooxygenase-2	27,43	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in patients with surgically resectable adenocarcinoma of the oesophagus .
16806914	0	COX-2	124,129	cyclooxygenase-2	106,122	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16847764	0	COX-2	43,48	cyclooxygenase-2	25,41	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of cyclooxygenase-2 -LRB- COX-2 -RRB- in multiple_myeloma .
16979925	0	COX-2	56,61	cyclooxygenase-2	38,54	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nuclear_factor-kappaB -LRB- NF-kappaB -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- expression in the oral mucosa following cancer chemotherapy .
17139446	0	COX-2	41,46	cyclooxygenase-2	23,39	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice .
17147116	0	COX-2	104,109	cyclooxygenase-2	86,102	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Flow cytometric quantitative analysis of multiple_tumor_suppressor_gene_1 -LRB- MTS1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- gene expressions in invasive breast_cancers and their clinical significance -RSB- .
17181139	0	COX-2	34,39	cyclooxygenase-2	16,32	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Scaffold of the cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor carprofen_provides Alzheimer gamma-secretase modulators .
17186551	0	COX-2	54,59	cyclooxygenase-2	36,52	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of UVB-induced and basal cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin in mouse keratinocytes : role of USF transcription factors .
17368333	0	COX-2	30,35	cyclooxygenase-2	12,28	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of cyclooxygenase-2 -LRB- COX-2 -RRB- in inflammatory bone resorption .
17409801	0	COX-2	138,143	cyclooxygenase-2	120,136	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Phase II study of gefitinib , an epidermal growth factor receptor tyrosine kinase inhibitor -LRB- EGFR-TKI -RRB- , and celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , in patients with platinum refractory non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
17706175	0	COX-2	77,82	cyclooxygenase-2	59,75	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere .
17729162	0	COX-2	62,67	cyclooxygenase-2	44,60	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Radiosensitization of human glioma cells by cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition : independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration .
17825788	0	COX-2	38,43	cyclooxygenase-2	20,36	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice .
17950526	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human pancreatic_carcinoma cells by the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- system .
17996688	0	COX-2	69,74	cyclooxygenase-2	51,67	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression through the modulation of multiple targets in COX-2 gene promoter .
18042295	0	COX-2	35,40	cyclooxygenase-2	17,33	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The effects of a cyclooxygenase-2 -LRB- COX-2 -RRB- expression and inhibition on human uveal_melanoma cell proliferation and macrophage nitric_oxide production .
18054463	0	COX-2	41,46	cyclooxygenase-2	23,39	COX-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor increases pentylenetetrazol seizure threshold in mice : possible involvement of adenosinergic mechanism .
18297687	0	COX-2	115,120	cyclooxygenase-2	97,113	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vitamin_C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- expression and the modulation of insulin-like_growth_factor_II _ -LRB- IGF-II -RRB- production .
18348265	0	COX-2	42,47	cyclooxygenase-2	24,40	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin _ D3 , a less calcemic vitamin_D analog .
18481165	0	COX-2	49,54	cyclooxygenase-2	31,47	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Selective increase of neuronal cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vulnerable brain regions of rats with experimental Wernicke 's _ encephalopathy : effect of nimesulide .
18758643	0	COX-2	56,61	cyclooxygenase-2	38,54	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of the cyclooxygenase-2 -LRB- COX-2 -RRB- in gastric_cancer .
19037084	0	COX-2	28,33	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition reduces proteinuria in renal patients .
19428370	0	COX-2	46,51	cyclooxygenase-2	28,44	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphisms of cyclooxygenase-2 -LRB- COX-2 -RRB- gene and risk for esophageal_squmaous_cell_carcinoma .
19519538	0	COX-2	28,33	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors used for preventing or regressing cancer .
19523822	0	COX-2	88,93	cyclooxygenase-2	70,86	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
19821125	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in an advanced metastasized hypopharyngeal_carcinoma and cultured_tumor cells .
19836060	0	COX-2	42,47	cyclooxygenase-2	24,40	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic relevance of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in Chinese patients with prostate_cancer .
20489206	0	COX-2	95,100	cyclooxygenase-2	77,93	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Leukotriene_B -LRB- 4 -RRB- BLT receptor signaling regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of Ras/Raf/ERK / p42 AUF1 pathway .
20627335	0	COX-2	46,51	cyclooxygenase-2	28,44	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphisms of cyclooxygenase-2 -LRB- COX-2 -RRB- gene and risk for urinary bladder_cancer in North India .
20724158	0	COX-2	28,33	cyclooxygenase-2	10,26	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors and breast_cancer risk .
20882760	0	COX-2	41,46	cyclooxygenase-2	23,39	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	Effect of preferential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor against 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -LRB- MPTP -RRB- - induced striatal lesions in rats : behavioral , biochemical and histological evidences .
20926918	0	COX-2	94,99	cyclooxygenase-2	76,92	COX-2	cyclooxygenase-2	100009248(Tax:9986)	100009248(Tax:9986)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Endoplasmic reticulum stress -LRB- ER-stress -RRB- by 2-deoxy-D-glucose -LRB- 2DG -RRB- reduces cyclooxygenase-2 -LRB- COX-2 -RRB- expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes .
21198273	0	COX-2	45,50	cyclooxygenase-2	27,43	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Association of the 8473T > C cyclooxygenase-2 -LRB- COX-2 -RRB- gene polymorphism with lung_cancer risk in Asians .
21316237	0	COX-2	99,104	cyclooxygenase-2	81,97	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and evaluation of 1,5-diaryl-substituted _ tetrazoles as novel selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
21612568	0	COX-2	77,82	cyclooxygenase-2	59,75	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Sweet 's _ syndrome associated with the intake of a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor .
21682897	0	COX-2	151,156	cyclooxygenase-2	133,149	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro : activation of an anti-inflammatory cyclooxygenase-2 -LRB- COX-2 -RRB- pathway .
22016040	0	COX-2	47,52	cyclooxygenase-2	29,45	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Low-level laser irradiation , cyclooxygenase-2 -LRB- COX-2 -RRB- expression and necrosis of random skin flaps in rats .
22341941	0	COX-2	55,60	cyclooxygenase-2	37,53	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Novel 5-substituted_1H-tetrazoles as cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
22460097	0	COX-2	32,37	cyclooxygenase-2	14,30	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in pituitary_tumours .
22900350	0	COX-2	122,127	cyclooxygenase-2	104,120	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Rationalization of physico-chemical properties of 5 , _ 6-diarylthiazolo _ -LSB- 3,2-b -RSB- -1 , _ 2 , _ 4-triazoles towards cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition : a QSAR approach .
23776069	0	COX-2	83,88	cyclooxygenase-2	60,76	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The -1195 G allele increases the transcriptional activity of cyclooxygenase-2 gene -LRB- COX-2 -RRB- in colon_cancer cell lines .
24878108	0	COX-2	45,50	cyclooxygenase-2	27,43	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Different detectability of cyclooxygenase-2 -LRB- COX-2 -RRB- protein in standard paraffin sections and tissue microarrays of human melanomas and naevi - comparative study .
25196686	0	COX-2	30,35	cyclooxygenase-2	12,28	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Increase in cyclooxygenase-2 -LRB- COX-2 -RRB- expression in keratinocytes and dermal fibroblasts in photoaged skin .
25219899	0	COX-2	139,144	cyclooxygenase-2	121,137	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis , biological evaluation and docking analysis of 3-methyl-1-phenylchromeno -LSB- 4,3-c -RSB- pyrazol-4 -LRB- 1H -RRB- - ones as potential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
25242400	0	COX-2	37,42	cyclooxygenase-2	19,35	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- by cannabidiolic_acid in human breast_cancer cells .
25252849	0	COX-2	48,53	cyclooxygenase-2	30,46	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hu-antigen receptor -LRB- HuR -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human non-small-cell_lung_carcinoma : associations with clinicopathological parameters , tumor proliferative capacity and patients ' survival .
25549551	0	COX-2	81,86	cyclooxygenase-2	63,79	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : Anti-inflammatory and analgesic activities .
26608958	0	COX-2	52,57	cyclooxygenase-2	34,50	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in oral nevi and melanoma .
8848551	0	COX-2	35,40	cyclooxygenase-2	17,33	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	The induction of cyclooxygenase-2 -LRB- COX-2 -RRB- in intact human amnion tissue by interleukin-4 .
8958057	0	COX-2	37,42	cyclooxygenase-2	19,35	COX-2	cyclooxygenase-2	5743	5743	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- by interleukin-1 receptor antagonist in human monocytes .
9665655	0	COX-2	51,56	cyclooxygenase-2	33,49	COX-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Differential effect of selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor NS_398 and diclofenac on formalin-induced nociception in the rat .
10987308	0	COX-2	32,37	cyclooxygenase_2	14,30	COX-2	cyclooxygenase 2	5743	5743	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclooxygenase_2 -LRB- COX-2 -RRB- in human glioma and in vitro inhibition by a specific COX-2 inhibitor , NS-398 .
11229771	0	COX-2	27,32	cyclooxygenase_2	9,25	COX-2	cyclooxygenase 2	5743	5743	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pimarane cyclooxygenase_2 -LRB- COX-2 -RRB- inhibitor and its structure-activity relationship .
11468975	0	COX-2	40,45	cyclooxygenase_2	11,27	COX-2	cyclooxygenase 2	5743	5743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- Selective cyclooxygenase_2 inhibitors -LRB- COX-2 -RRB- -RSB- .
14688483	0	COX-2	30,35	cyclooxygenase_2	12,28	COX-2	cyclooxygenase 2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of cyclooxygenase_2 -LRB- COX-2 -RRB- expression during malignant_melanoma_progression .
17350020	0	COX-2	72,77	cyclooxygenase_2	54,70	COX-2	cyclooxygenase 2	5743	5743	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Increased risk of incident stroke associated with the cyclooxygenase_2 -LRB- COX-2 -RRB- G-765C polymorphism in African-Americans : the Atherosclerosis Risk in Communities Study .
17479405	0	COX-2	50,55	cyclooxygenase_2	32,48	COX-2	cyclooxygenase 2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphisms in the cyclooxygenase_2 -LRB- COX-2 -RRB- gene and risk of breast_cancer in a Chinese population .
24988319	0	COX-2	44,49	cyclooxygenase_2	26,42	COX-2	cyclooxygenase 2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Reversible suppression of cyclooxygenase_2 -LRB- COX-2 -RRB- expression in vivo by inducible RNA interference .
8789408	0	COX-2	33,38	cyclooxygenase_2	15,31	COX-2	cyclooxygenase 2	100135607(Tax:10141)	100135607(Tax:10141)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of cyclooxygenase_2 -LRB- COX-2 -RRB- in intrinsic tone of isolated guinea_pig trachea .
22982228	0	COX-2	55,60	eIF2a	83,88	COX-2	eIF2a	5743	1965	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2a , p38-MAPK and NF-kB in advanced glycation end products stimulated human chondrocytes .
17877615	0	COX-2	14,19	epidermal_growth_factor_receptor	86,118	COX-2	epidermal growth factor receptor	5743	1956	Gene	Gene	Inhibition|nmod|START_ENTITY decreases|nsubj|Inhibition decreases|advcl|blocking blocking|dobj|transactivation transactivation|compound|END_ENTITY	Inhibition of COX-2 with NS-398 decreases colon_cancer cell motility through blocking epidermal_growth_factor_receptor transactivation : possibilities for combination therapy .
19671676	0	COX-2	18,23	epidermal_growth_factor_receptor	60,92	COX-2	epidermal growth factor receptor	5743	1956	Gene	Gene	Cyclooxygenase-2|appos|START_ENTITY regulates|nsubj|Cyclooxygenase-2 regulates|dobj|expression expression|nmod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- negatively regulates expression of epidermal_growth_factor_receptor and causes resistance to gefitinib in COX-2-overexpressing cancer cells .
20850495	0	COX-2	91,96	epidermal_growth_factor_receptor	19,51	COX-2	epidermal growth factor receptor	5743	1956	Gene	Gene	genes|compound|START_ENTITY Involvement|dep|genes Involvement|nmod|END_ENTITY	Involvement of the epidermal_growth_factor_receptor in Pb + - induced activation of cPLA / COX-2 genes and PGE production in vascular smooth muscle cells .
21874253	0	COX-2	115,120	epidermal_growth_factor_receptor	55,87	COX-2	epidermal growth factor receptor	4513	1956	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Lipopolysaccharide initiates a bypass feedback loop of epidermal_growth_factor_receptor signaling by HPS70-induced COX-2 in H22 hepatocarcinoma cells .
14719508	0	COX-2	78,83	iNOS	88,92	COX-2	iNOS	5743	4843	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Expression of beta-catenin , COX-2 and iNOS in colorectal_cancer : relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia .
16572897	0	COX-2	5,10	iNOS	12,16	COX-2	iNOS	4513	4843	Gene	Gene	P53|appos|START_ENTITY END_ENTITY|nsubj|P53	P53 , COX-2 , iNOS protein expression changes and their relationship with anti-oxidant enzymes in surgically and multi-modality treated esophageal_carcinoma patients .
18057724	0	COX-2	32,37	iNOS	26,30	COX-2	iNOS	19225(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Inhibition of LPS-induced iNOS , COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells .
18579232	0	COX-2	35,40	iNOS	41,45	COX-2	iNOS	4513	4843	Gene	Gene	induce|dobj|START_ENTITY antibodies|acl:relcl|induce antibodies|dep|END_ENTITY	Chagasic antibodies induce cardiac COX-2 / iNOS mRNA expression with PGE2/NO production .
18634870	0	COX-2	83,88	iNOS	73,77	COX-2	iNOS	19225(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	HO-1 and JAK-2 / STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline_alkaloid , CKD712 , in cells activated with lipopolysacchride .
18821215	0	COX-2	42,47	iNOS	36,40	COX-2	iNOS	5743	4843	Gene	Gene	production|amod|START_ENTITY END_ENTITY|appos|production	Retinoid_acid inhibits IL-1-induced iNOS , COX-2 and chemokine production in human chondrocytes .
19222121	0	COX-2	32,37	iNOS	26,30	COX-2	iNOS	17709(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Inhibition|appos|expression Inhibition|nmod|END_ENTITY	Inhibition of LPS-induced iNOS , COX-2 and inflammatory mediator expression by paeonol through the MAPKs inactivation in RAW 264.7 cells .
20845789	0	COX-2	60,65	iNOS	54,58	COX-2	iNOS	26198(Tax:10116)	24599(Tax:10116)	Gene	Gene	-RSB-|nmod:poss|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Effects of Valeriana amurensis on the expressions of iNOS , COX-2 and IkappaCB-alpha in Alzheimer 's _ disease model rat 's brain -RSB- .
21656334	0	COX-2	81,86	iNOS	75,79	COX-2	iNOS	19225(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Phellinus baumii ethyl_acetate extract inhibits lipopolysaccharide-induced iNOS , COX-2 , and proinflammatory cytokine expression in RAW264 .7 cells .
22197135	0	COX-2	100,105	iNOS	94,98	COX-2	iNOS	4513	4843	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|compound|END_ENTITY	A concise synthesis of viscolin , and its anti-inflammatory effects through the suppression of iNOS , COX-2 , ERK phosphorylation and proinflammatory cytokines expressions .
22331023	0	COX-2	37,42	iNOS	49,53	COX-2	iNOS	5743	4843	Gene	Gene	MPO|compound|START_ENTITY encoding|nmod|MPO genes|acl|encoding expression|nmod|genes END_ENTITY|nsubj|expression	The expression of genes encoding for COX-2 , MPO , iNOS , and sPLA2-IIA in patients with recurrent depressive_disorder .
22683859	0	COX-2	30,35	iNOS	0,4	COX-2	iNOS	4513	4843	Gene	Gene	pathway|compound|START_ENTITY signaling|nmod|pathway END_ENTITY|acl|signaling	iNOS signaling interacts with COX-2 pathway in colonic fibroblasts .
23886206	0	COX-2	96,101	iNOS	90,94	COX-2	iNOS	17709(Tax:10090)	18126(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24556222	0	COX-2	39,44	iNOS	46,50	COX-2	iNOS	17709(Tax:10090)	18126(Tax:10090)	Gene	Gene	cytokines|compound|START_ENTITY cytokines|dep|END_ENTITY	Tinospora cordifolia extract modulates COX-2 , iNOS , ICAM-1 , pro-inflammatory cytokines and redox status in murine model of asthma .
25000190	0	COX-2	66,71	iNOS	72,76	COX-2	iNOS	4513	4843	Gene	Gene	/|compound|START_ENTITY signaling|nsubj|/ signaling|dep|END_ENTITY	Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2 / iNOS and NF-kB/p300 signaling pathways .
27091651	0	COX-2	24,29	iNOS	111,115	COX-2	iNOS	19225(Tax:10090)	18126(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY improves|nsubj|inhibition improves|ccomp|wound wound|nmod|reduction reduction|nmod|expression expression|amod|END_ENTITY	Selective inhibition of COX-2 improves cutaneous wound healing of pressure ulcers in mice through reduction of iNOS expression .
22006370	0	COX-2	65,70	insulin-like_growth_factor-1	11,39	COX-2	insulin-like growth factor-1	17709(Tax:10090)	16000(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Transgenic insulin-like_growth_factor-1 stimulates activation of COX-2 signaling in mammary glands .
20883667	0	COX-2	79,84	interleukin-1b	61,75	COX-2	interleukin-1b	4513	3553	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Analysis of isoform specific ERK signaling on the effects of interleukin-1b on COX-2 expression and PGE2 production in human chondrocytes .
16809483	0	COX-2	77,82	interleukin-6	12,25	COX-2	interleukin-6	29527(Tax:10116)	24498(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain .
15014433	0	COX-2	64,69	mPGES-1	70,77	COX-2	mPGES-1	19225(Tax:10090)	64292(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|amod|END_ENTITY	Hyperplastic_gastric_tumors induced by activated macrophages in COX-2 / mPGES-1 transgenic_mice .
25767384	0	COX-2	58,63	miR-146a	46,54	COX-2	miR-146a	4513	406938	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic_obstructive_pulmonary_disease .
15655349	0	COX-2	45,50	nuclear_factor-kappa_B	71,93	COX-2	nuclear factor-kappa B	5743	4790	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
19148359	0	COX-2	12,17	p16	6,9	COX-2	p16	4513	1029	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	-LSB- p53 , p16 E COX-2 expression in esophageal_squamous_cell_carcinoma and histopathological association -RSB- .
12746433	0	COX-2	238,243	p38	134,137	COX-2	p38	5743	1432	Gene	Gene	mRNA|compound|START_ENTITY region|nmod|mRNA role|dep|region cascade|dep|role cascade|amod|mRNA mRNA|nmod|activation activation|nmod|kinase kinase|amod|END_ENTITY	T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade : role of distal sequences in the 3 ' - untranslated region of COX-2 mRNA .
12746433	0	COX-2	85,90	p38	134,137	COX-2	p38	5743	1432	Gene	Gene	cascade|appos|START_ENTITY cascade|amod|mRNA mRNA|nmod|activation activation|nmod|kinase kinase|amod|END_ENTITY	T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade : role of distal sequences in the 3 ' - untranslated region of COX-2 mRNA .
12871860	0	COX-2	31,36	p38	0,3	COX-2	p38	5743	1432	Gene	Gene	expression|compound|START_ENTITY mediate|dobj|expression mediate|nsubj|MAPK MAPK|compound|END_ENTITY	p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes .
14530261	0	COX-2	86,91	p38	43,46	COX-2	p38	5743	5594	Gene	Gene	expression|compound|START_ENTITY potentiates|dobj|expression potentiates|nsubj|Alterations Alterations|nmod|localization localization|nmod|MAPK MAPK|amod|END_ENTITY	Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells .
14665434	0	COX-2	45,50	p38	0,3	COX-2	p38	17709(Tax:10090)	26416(Tax:10090)	Gene	Gene	mediates|dep|START_ENTITY mediates|amod|END_ENTITY	p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes : implications for the actin cytoskeleton .
14742690	0	COX-2	17,22	p38	62,65	COX-2	p38	4513	1432	Gene	Gene	stabilization|compound|START_ENTITY stabilization|nmod|activation activation|amod|END_ENTITY	Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts .
15001457	0	COX-2	142,147	p38	99,102	COX-2	p38	4513	1432	Gene	Gene	coupling|compound|START_ENTITY effects|nmod|coupling expression|dep|effects expression|nmod|cells cells|nmod|pathway pathway|amod|END_ENTITY	HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway : effects on COX-2 / PGI-synthase coupling .
15056456	0	COX-2	9,14	p38	61,64	COX-2	p38	5743	1432	Gene	Gene	expression|compound|START_ENTITY precede|nsubj|expression precede|dobj|activation activation|nummod|END_ENTITY	Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex .
15735738	0	COX-2	22,27	p38	69,72	COX-2	p38	19225(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|acl|blocking blocking|dobj|activation activation|nmod|kinase kinase|amod|END_ENTITY	-LSB- 6 -RSB- - Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol_ester-stimulated mouse skin .
16000872	0	COX-2	36,41	p38	122,125	COX-2	p38	5743	1432	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|parataxis|kinase kinase|nsubj|MAP MAP|compound|END_ENTITY	Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes -LRB- HaCaT -RRB- by inhibiting activation of AP-1 : p38 MAP kinase and JNK as potential upstream targets .
16054711	0	COX-2	19,24	p38	49,52	COX-2	p38	26198(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Anisomycin induces COX-2 mRNA expression through p38 -LRB- MAPK -RRB- and CREB independent of small GTPases in intestinal epithelial cells .
17276891	0	COX-2	75,80	p38	52,55	COX-2	p38	26198(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulating|dobj|expression modulating|nsubj|END_ENTITY	Curcumin , a Curcuma longa constituent , acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis .
19145780	0	COX-2	47,52	p38	0,3	COX-2	p38	29527(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY contributes|nmod|expression contributes|nsubj|MAPK MAPK|compound|END_ENTITY	p38 MAPK contributes to angiotensin_II-induced COX-2 expression in aortic fibroblasts from normotensive and hypertensive rats .
19287971	0	COX-2	28,33	p38	59,62	COX-2	p38	5743	1432	Gene	Gene	expression|compound|START_ENTITY Sulforaphane|dobj|expression Sulforaphane|advcl|activating activating|dobj|END_ENTITY	Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells .
21388279	0	COX-2	50,55	p38	32,35	COX-2	p38	4513	1432	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Involvement of P2Y6_receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes .
24558308	0	COX-2	42,47	p38	74,77	COX-2	p38	4513	1432	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|advcl|suppressing suppressing|dobj|END_ENTITY	Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells .
24875145	0	COX-2	51,56	p38	90,93	COX-2	p38	19225(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|parataxis|kinase kinase|nsubj|MAP MAP|compound|END_ENTITY	Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin : p38 MAP kinase and JNK as potential targets .
17481611	0	COX-2	49,54	p38MAPK	74,81	COX-2	p38MAPK	17709(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|activation activation|amod|END_ENTITY	The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell .
14500353	0	COX-2	14,19	p53	105,108	COX-2	p53	4513	7157	Gene	Gene	Inhibition|nmod|START_ENTITY increases|nsubj|Inhibition increases|dobj|localization localization|nmod|END_ENTITY	Inhibition of COX-2 in colon_cancer cell lines by celecoxib increases the nuclear localization of active p53 .
15707991	0	COX-2	0,5	p53	16,19	COX-2	p53	5743	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis .
18617777	0	COX-2	14,19	p53	55,58	COX-2	p53	5743	7157	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|accumulation accumulation|nmod|END_ENTITY	Expression of COX-2 is associated with accumulation of p53 in pancreatic_cancer : analysis of COX-2 and p53 expression in premalignant and malignant_ductal_pancreatic_lesions .
18617777	0	COX-2	93,98	p53	55,58	COX-2	p53	5743	7157	Gene	Gene	expression|compound|START_ENTITY analysis|nmod|expression END_ENTITY|dep|analysis	Expression of COX-2 is associated with accumulation of p53 in pancreatic_cancer : analysis of COX-2 and p53 expression in premalignant and malignant_ductal_pancreatic_lesions .
19082758	0	COX-2	51,56	p53	0,3	COX-2	p53	4513	7157	Gene	Gene	_|amod|START_ENTITY overexpression|nmod|_ mediate|dobj|overexpression mediate|nsubj|END_ENTITY	p53 and ATF-2 partly mediate the overexpression of COX-2 in H -LRB- 2 -RRB- O _ -LRB- 2 -RRB- - induced premature senescence of human fibroblasts .
19148359	0	COX-2	12,17	p53	1,4	COX-2	p53	4513	7157	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	-LSB- p53 , p16 E COX-2 expression in esophageal_squamous_cell_carcinoma and histopathological association -RSB- .
21071999	0	COX-2	63,68	p53	29,32	COX-2	p53	5743	7157	Gene	Gene	expression|compound|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|Pifithrin-a Pifithrin-a|appos|inhibitor inhibitor|nmod|transactivation transactivation|compound|END_ENTITY	Pifithrin-a , an inhibitor of p53 transactivation , up-regulates COX-2 expression through an MAPK-dependent pathway .
22623379	0	COX-2	90,95	p53	17,20	COX-2	p53	26198(Tax:10116)	301300(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY combination|nmod|inhibitor signaling|nmod|combination signaling|nsubj|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor , Celecoxib and Dolastatin 15 , a marine mollusk linear peptide in experimental colon carcinogenesis .
23167625	0	COX-2	10,15	p53	109,112	COX-2	p53	4513	7157	Gene	Gene	inhibitor|compound|START_ENTITY decreases|nsubj|inhibitor decreases|xcomp|independent independent|nmod|END_ENTITY	Selective COX-2 inhibitor -LRB- celecoxib -RRB- decreases cellular growth in prostate_cancer cell lines independent of p53 .
23612655	0	COX-2	11,16	p53	163,166	COX-2	p53	5743	7157	Gene	Gene	factors|amod|START_ENTITY Changes|nmod|factors associated|nsubjpass|Changes associated|nmod|downregulation downregulation|nmod|gene gene|compound|END_ENTITY	Changes in COX-2 and oxidative damage factors during differentiation of human mesenchymal stem cells to hepatocyte-like cells is associated with downregulation of p53 gene .
26756900	0	COX-2	0,5	p53	54,57	COX-2	p53	5743	7157	Gene	Gene	NS-398|compound|START_ENTITY suppresses|nsubj|NS-398 suppresses|dobj|accumulation accumulation|compound|END_ENTITY	COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation .
15056456	0	COX-2	9,14	pRb	49,52	COX-2	pRb	5743	5925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex .
14555539	0	COX-2	11,16	peroxisome_proliferator-activated_receptor_gamma	41,89	COX-2	peroxisome proliferator-activated receptor gamma	4513	5468	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Control of COX-2 gene expression through peroxisome_proliferator-activated_receptor_gamma in human cervical_cancer cells .
19056168	0	COX-2	14,19	peroxisome_proliferator-activated_receptor_gamma	38,86	COX-2	peroxisome proliferator-activated receptor gamma	5743	5468	Gene	Gene	START_ENTITY|nmod|synergistically synergistically|amod|END_ENTITY	Inhibition of COX-2 and activation of peroxisome_proliferator-activated_receptor_gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic_carcinoma cells .
21995456	0	COX-2	64,69	prostaglandin_synthetase-2	29,55	COX-2	prostaglandin synthetase-2	4513	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the 3 ` UTR of the prostaglandin_synthetase-2 -LRB- PTGS-2 / COX-2 -RRB- gene in non-melanoma_skin_cancer after organ transplantation .
12434137	0	COX-2	29,34	renin	67,72	COX-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Effects of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on plasma and renal renin in diabetes .
16444599	0	COX-2	31,36	tNOX	0,4	COX-2	tNOX	4513	10495	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	tNOX , an alternative target to COX-2 to explain the anticancer activities of non-steroidal anti-inflammatory drugs -LRB- NSAIDS -RRB- .
1324471	0	COX1	43,47	aI3	32,35	COX1	aI3	854598(Tax:4932)	854595(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Splice site selection by intron aI3 of the COX1 gene from Saccharomyces_cerevisiae .
10803883	0	COX1	78,82	cytochrome_c_oxidase_subunit-1	46,76	COX1	cytochrome c oxidase subunit-1	854598(Tax:4932)	854598(Tax:4932)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Mss51p , a putative translational activator of cytochrome_c_oxidase_subunit-1 -LRB- COX1 -RRB- mRNA , is required for synthesis of Cox1p in Saccharomyces_cerevisiae .
15145942	0	COX17	22,27	COX23	0,5	COX17	COX23	850651(Tax:4932)	856516(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	COX23 , a homologue of COX17 , is required for cytochrome oxidase assembly .
15228443	0	COX2	18,22	Cyclooxygenase_2	0,16	COX2	Cyclooxygenase 2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase_2 -LRB- COX2 -RRB- expression is associated with poor outcome in ER-negative , but not ER-positive , breast_cancer .
24970799	0	COX2	33,37	FYN	50,53	COX2	FYN	4513	2534	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity regulation|nmod|END_ENTITY	Post-translational regulation of COX2 activity by FYN in prostate_cancer cells .
23973922	0	COX2	105,109	NOD2	87,91	COX2	NOD2	17709(Tax:10090)	257632(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2 .
15916616	0	COX2	22,26	Pet111p	52,59	COX2	Pet111p	854622(Tax:4932)	855299(Tax:4932)	Gene	Gene	activator|compound|START_ENTITY activator|appos|END_ENTITY	Overexpression of the COX2 translational activator , Pet111p , prevents translation of COX1 mRNA and cytochrome c oxidase assembly in mitochondria of Saccharomyces_cerevisiae .
24051096	0	COX2	9,13	RXRa	66,70	COX2	RXRa	17709(Tax:10090)	20181(Tax:10090)	Gene	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Elevated COX2 expression and PGE2 production by downregulation of RXRa in senescent macrophages .
21494638	0	COX2	51,55	cyclooxygenase-2	33,49	COX2	cyclooxygenase-2	5743	5743	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Wnt/b-catenin signaling enhances cyclooxygenase-2 -LRB- COX2 -RRB- transcriptional activity in gastric_cancer cells .
21035557	0	COX2	93,97	cyclooxygenase_2	75,91	COX2	cyclooxygenase 2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Selenomethionine inhibits IL-1b inducible nitric_oxide synthase -LRB- iNOS -RRB- and cyclooxygenase_2 -LRB- COX2 -RRB- expression in primary human chondrocytes .
21803118	0	COX2	47,51	cyclooxygenase_2	29,45	COX2	cyclooxygenase 2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prolactin -LRB- PRL -RRB- induction of cyclooxygenase_2 -LRB- COX2 -RRB- expression and prostaglandin -LRB- PG -RRB- production in hamster Leydig cells .
24202787	0	COX20	67,72	FAM36A	74,80	COX20	FAM36A	116228	116228	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Recessive dystonia-ataxia_syndrome in a Turkish family caused by a COX20 -LRB- FAM36A -RRB- mutation .
24403053	0	COX20	6,11	SCO1	28,32	COX20	SCO1	116228	6341	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase .
15145942	0	COX23	0,5	COX17	22,27	COX23	COX17	856516(Tax:4932)	850651(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	COX23 , a homologue of COX17 , is required for cytochrome oxidase assembly .
23619098	0	COX3	34,38	Cytochrome_c_oxidase_subunit_III	0,32	COX3	Cytochrome c oxidase subunit III	4514	4514	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Cytochrome_c_oxidase_subunit_III -LRB- COX3 -RRB- gene , an informative marker for phylogenetic analysis and differentiation of Babesia species in China .
2852136	0	COX5b	66,71	REO1	18,22	COX5b	REO1	854695(Tax:4932)	856178(Tax:4932)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of REO1 , a gene involved in negative regulation of COX5b and ANB1 in aerobically grown Saccharomyces_cerevisiae .
7488164	0	COX6	63,67	cytochrome_c_oxidase_subunit_VI	25,56	COX6	cytochrome c oxidase subunit VI	856448(Tax:4932)	856448(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Oxygen regulation of the cytochrome_c_oxidase_subunit_VI gene , COX6 , in Saccharomyces_cerevisiae .
7575509	0	COX6	117,121	cytochrome_c_oxidase_subunit_VI	79,110	COX6	cytochrome c oxidase subunit VI	856448(Tax:4932)	856448(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	pH and the cAMP-dependent protein kinase mediate growth phase induction of the cytochrome_c_oxidase_subunit_VI gene , COX6 , in Saccharomyces_cerevisiae .
24351431	0	COXIV	22,27	Leptin	0,6	COXIV	Leptin	1327	3952	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Leptin stimulation of COXIV is impaired_in_obese_skeletal_muscle_myotubes .
8092265	0	COX_II	21,27	IL-1_beta	0,9	COX II	IL-1 beta	26198(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY stabilizes|dobj|mRNA stabilizes|nsubj|END_ENTITY	IL-1_beta stabilizes COX_II mRNA in renal mesangial cells : role of 3 ' - untranslated region .
19336478	0	CO_II	44,49	SCO2	6,10	CO II	SCO2	4513	9997	Gene	Gene	synthesis|nmod|START_ENTITY required|nmod|synthesis required|nsubjpass|END_ENTITY	Human SCO2 is required for the synthesis of CO_II and as a thiol-disulphide oxidoreductase for SCO1 .
8592003	0	CP-10	13,18	S100	0,4	CP-10	S100	6279	6271	Gene	Gene	stimulates|compound|START_ENTITY stimulates|compound|END_ENTITY	S100 protein CP-10 stimulates myeloid cell chemotaxis without activation .
9389698	0	CP-10	43,48	S100	17,21	CP-10	S100	20201(Tax:10090)	20193(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Induction of the S100 chemotactic protein , CP-10 , in murine microvascular endothelial cells by proinflammatory stimuli .
9662479	0	CP1	72,75	cysteine_proteinase	51,70	CP1	cysteine proteinase	36546(Tax:7227)	36546(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and associated mutational effects of the cysteine_proteinase -LRB- CP1 -RRB- gene of Drosophila_melanogaster .
21620453	0	CP110	40,45	Kif24	19,24	CP110	Kif24	9738	347240	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis .
22365849	0	CP110	65,70	Klp10A	0,6	CP110	Klp10A	33136(Tax:7227)	32049(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Klp10A , a microtubule-depolymerizing kinesin-13 , cooperates with CP110 to control Drosophila centriole length .
19287002	0	CP12	0,4	glyceraldehyde-3-phosphate_dehydrogenase	86,126	CP12	glyceraldehyde-3-phosphate dehydrogenase	5719874(Tax:3055)	5715019(Tax:3055)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	CP12 from Chlamydomonas_reinhardtii , a permanent specific `` chaperone-like '' protein of glyceraldehyde-3-phosphate_dehydrogenase .
16648487	0	CP2	26,29	GATA-1	35,41	CP2	GATA-1	1356	2623	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters .
12552318	0	CPA4	47,51	carboxypeptidase_A4	20,39	CPA4	carboxypeptidase A4	51200	51200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The novel imprinted carboxypeptidase_A4 gene -LRB- CPA4 -RRB- in the 7q32 imprinting domain .
21922598	0	CPA6	26,30	Carboxypeptidase_A6	0,19	CPA6	Carboxypeptidase A6	57094	57094	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Carboxypeptidase_A6 gene -LRB- CPA6 -RRB- mutations in a recessive familial form of febrile_seizures and temporal_lobe_epilepsy and in sporadic temporal_lobe_epilepsy .
23810536	0	CPAP	33,37	CEP120	0,6	CPAP	CEP120	55835	153241	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	CEP120 and SPICE1 cooperate with CPAP in centriole elongation .
23857771	0	CPAP	22,26	CEP120	0,6	CPAP	CEP120	55835	153241	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CEP120 interacts with CPAP and positively regulates centriole elongation .
22020124	0	CPAP	51,55	STIL	31,35	CPAP	STIL	55835	6491	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation .
16678151	0	CPB-3	11,16	DAZ-1	32,37	CPB-3	DAZ-1	172244(Tax:6239)	173931(Tax:6239)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	C. _ elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development .
23178487	0	CPEB	141,145	Tob	26,29	CPEB	Tob	64506	10140	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic_polyadenylation_element-binding_protein CPEB .
23178487	0	CPEB	141,145	c-myc	49,54	CPEB	c-myc	64506	4609	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic_polyadenylation_element-binding_protein CPEB .
26627607	0	CPEB1	24,29	VEGF	74,78	CPEB1	VEGF	64506	7422	Gene	Gene	Functions|nmod|START_ENTITY Functions|nmod|END_ENTITY	Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of VEGF and Angiogenesis in Chronic_Liver_Disease .
21620800	0	CPEB1	0,5	iNOS	44,48	CPEB1	iNOS	293056(Tax:10116)	24599(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes .
26546435	0	CPEB4	0,5	Vimentin	21,29	CPEB4	Vimentin	80315	7431	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CPEB4 interacts with Vimentin and involves in progressive features and poor prognosis of patients with astrocytic_tumors .
23275439	0	CPI-17	26,32	GATA-6	0,6	CPI-17	GATA-6	68458(Tax:10090)	14465(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY activate|dobj|transcription activate|nsubj|END_ENTITY	GATA-6 and NF-kB activate CPI-17 gene transcription and regulate Ca2 + sensitization of smooth muscle contraction .
12733988	0	CPI-17	345,351	protein_kinase_C	328,344	CPI-17	protein kinase C	94274	112476	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Differential signalling by muscarinic receptors in smooth muscle : m2-mediated inactivation of myosin_light_chain_kinase via Gi3 , Cdc42/Rac1 and p21-activated_kinase_1 pathway , and m3-mediated MLC20 -LRB- 20_kDa_regulatory_light_chain_of_myosin_II -RRB- phosphorylation via Rho-associated kinase/myosin _ phosphatase_targeting_subunit 1 and protein_kinase_C / CPI-17 pathway .
10924361	0	CPI-17	19,25	protein_kinase_N	66,82	CPI-17	protein kinase N	94274	5585	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of CPI-17 , an inhibitor of myosin phosphatase , by protein_kinase_N .
16162394	0	CPLX2	55,60	complexin_2	37,48	CPLX2	complexin 2	10814	10814	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural organization of the human complexin_2 gene -LRB- CPLX2 -RRB- and aspects of its functional activity .
9747031	0	CPO	48,51	coproporphyrinogen_oxidase	20,46	CPO	coproporphyrinogen oxidase	1371	1371	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation of coproporphyrinogen_oxidase -LRB- CPO -RRB- gene in a Japanese family .
9070890	0	CPP32	23,28	CPP32	83,88	CPP32	CPP32	12367(Tax:10090)	12367(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF .
9070890	0	CPP32	83,88	CPP32	23,28	CPP32	CPP32	12367(Tax:10090)	12367(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression of CPP32 in sensory neurons of mouse embryos and activation of CPP32 in the apoptosis induced by a withdrawal of NGF .
7983002	0	CPP32	0,5	Ced-3	98,103	CPP32	Ced-3	836	178272(Tax:6239)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	CPP32 , a novel human apoptotic protein with homology to Caenorhabditis_elegans cell death protein Ced-3 and mammalian interleukin-1_beta-converting_enzyme .
9367996	0	CPP32	66,71	IkappaB-alpha	19,32	CPP32	IkappaB-alpha	836	396093(Tax:9031)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro .
10200474	0	CPP32	34,39	TNF_or_anti-Fas	63,78	CPP32	TNF or anti-Fas	836	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Wortmannin enhances activation of CPP32 -LRB- Caspase-3 -RRB- induced by TNF_or_anti-Fas .
10769693	0	CPP32	128,133	c-Jun_N-terminal_kinase_1	87,112	CPP32	c-Jun N-terminal kinase 1	836	5599	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Enhancement of chemotherapeutic agents induced-apoptosis associated with activation of c-Jun_N-terminal_kinase_1 and caspase_3 -LRB- CPP32 -RRB- in bax-transfected gastric_cancer cells .
10812002	0	CPP32	111,116	caspase-3	101,110	CPP32	caspase-3	836	836	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	TNF-alpha induces apoptosis mediated by AEBSF-sensitive serine_protease -LRB- s -RRB- that may involve upstream caspase-3 / CPP32 protease activation in a human gastric_cancer cell line .
9305886	0	CPP32	96,101	caspase-3	86,95	CPP32	caspase-3	836	836	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3 / CPP32 inhibition .
9720729	0	CPP32	45,50	caspase-3	34,43	CPP32	caspase-3	836	836	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vinorelbine induces apoptosis and caspase-3 -LRB- CPP32 -RRB- expression in leukemia and lymphoma cells : a comparison with vincristine .
10847548	0	CPP32	42,47	caspase_3	32,41	CPP32	caspase 3	836	836	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of the pro-apoptotic caspase_3 / CPP32 in cutaneous basal and squamous_cell_carcinomas .
9363747	0	CPP32	36,41	caspase_3	25,34	CPP32	caspase 3	25402(Tax:10116)	25402(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Apoptotic cell death and caspase_3 -LRB- CPP32 -RRB- activation induced by calcium ionophore at low concentrations and their prevention by nerve growth factor in PC12 cells .
9512515	0	CPP32	36,41	caspase_3	26,35	CPP32	caspase 3	12367(Tax:10090)	12367(Tax:10090)	Gene	Gene	contribution|dep|START_ENTITY contribution|nmod|END_ENTITY	Essential contribution of caspase_3 / CPP32 to apoptosis and its associated nuclear changes .
976638	0	CPR	34,37	C-peptide	6,15	CPR	C-peptide	5447	3630	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Human C-peptide immunoreactivity -LRB- CPR -RRB- in blood and urine - evaluation of a radioimmunoassay method and its clinical applications .
25038863	0	CPR	70,73	cytochrome_P450_reductase	43,68	CPR	cytochrome P450 reductase	5447	5447	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Molecular population genetics of the NADPH cytochrome_P450_reductase -LRB- CPR -RRB- gene in Anopheles minimus .
24945150	0	CPR5	15,19	UVI4	47,51	CPR5	UVI4	836617(Tax:3702)	818827(Tax:3702)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CPR5 with cell cycle regulators UVI4 and OSD1 in Arabidopsis .
15044358	0	CPT-1	34,39	Carnitine_palmitoyltransferase-1	0,32	CPT-1	Carnitine palmitoyltransferase-1	12895(Tax:10090)	12895(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Carnitine_palmitoyltransferase-1 -LRB- CPT-1 -RRB- activity stimulation by cerulenin via sympathetic nervous system activation overrides cerulenin 's peripheral effect .
21965746	0	CPT-11	28,34	ERas	0,4	CPT-11	ERas	963084(Tax:115711)	3266	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	ERas enhances resistance to CPT-11 in gastric_cancer .
16619577	0	CPT-11	30,36	S-1	51,54	CPT-11	S-1	963084(Tax:115711)	5707	Gene	Gene	plus|amod|START_ENTITY study|nmod|plus CDDP|nsubj|study CDDP|nmod|gastric_cancer gastric_cancer|amod|END_ENTITY	Feasibility study of biweekly CPT-11 plus CDDP for S-1 - and paclitaxel-refractory , metastatic gastric_cancer .
18219915	0	CPT-11	99,105	S-1	93,96	CPT-11	S-1	963084(Tax:115711)	5707	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A case of unresectable gastric_cancer successfully treated with combination chemotherapy of S-1 _ + _ CPT-11 -RSB- .
18219916	0	CPT-11	144,150	S-1	11,14	CPT-11	S-1	963084(Tax:115711)	5707	Gene	Gene	combined|nmod|START_ENTITY combined|csubj|-LSB- -LSB-|dobj|case case|nmod|metastases metastases|amod|resistant resistant|amod|END_ENTITY	-LSB- A case of S-1 resistant multiple lung metastases after curative total gastrectomy for gastric_cancer successfully treated by S-1 combined with CPT-11 as the third-line chemotherapy -RSB- .
18219916	0	CPT-11	144,150	S-1	126,129	CPT-11	S-1	963084(Tax:115711)	5707	Gene	Gene	combined|nmod|START_ENTITY combined|csubj|-LSB- -LSB-|nmod|gastrectomy gastrectomy|nmod|gastric_cancer gastric_cancer|acl|treated treated|nmod|END_ENTITY	-LSB- A case of S-1 resistant multiple lung metastases after curative total gastrectomy for gastric_cancer successfully treated by S-1 combined with CPT-11 as the third-line chemotherapy -RSB- .
18799912	0	CPT-11	175,181	S-1	156,159	CPT-11	S-1	963084(Tax:115711)	5707	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- A case of advanced gastric_cancer with pulmonary_carcinomatous_lymphangitis and paraaortic_lymph_node_metastases responding to combination chemotherapy of S-1 and irinotecan -LRB- CPT-11 -RRB- -RSB- .
19692782	0	CPT-11	27,33	S-1	18,21	CPT-11	S-1	963084(Tax:115711)	5707	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	-LSB- Effectiveness of S-1 plus CPT-11 therapy for an elderly patient with recurrent colon_cancer -RSB- .
20087049	0	CPT-11	72,78	S-1	63,66	CPT-11	S-1	963084(Tax:115711)	5707	Gene	Gene	chemotherapy|compound|START_ENTITY chemotherapy|compound|END_ENTITY	-LSB- A case of advanced gastric_cancer with a complete response to S-1 plus CPT-11 chemotherapy for eight years -RSB- .
16257398	0	CPT-11	61,67	acetylcholinesterase	14,34	CPT-11	acetylcholinesterase	963084(Tax:115711)	43	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11 .
10220571	0	CPT-11	24,30	multidrug_resistance_protein	48,76	CPT-11	multidrug resistance protein	963084(Tax:115711)	4363	Gene	Gene	efflux|nmod|START_ENTITY efflux|nmod|END_ENTITY	ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug_resistance_protein -LRB- MRP -RRB- and its inhibition by PAK-104P .
1804390	0	CPT-11	46,52	tumor_necrosis_factor	91,112	CPT-11	tumor necrosis factor	963084(Tax:115711)	7124	Gene	Gene	activity|nmod|START_ENTITY Augmentation|nmod|activity Augmentation|nmod|END_ENTITY	Augmentation of antiproliferative activity of CPT-11 , a new derivative of camptothecin , by tumor_necrosis_factor against proliferation of gynecologic_tumor cell lines .
17089095	0	CPT1	87,91	carnitine_palmitoyltransferase_I	53,85	CPT1	carnitine palmitoyltransferase I	1374	1374	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants within the muscle and liver isoforms of the carnitine_palmitoyltransferase_I -LRB- CPT1 -RRB- gene interact with fat intake to modulate indices of obesity in French-Canadians .
9566999	0	CPT_I	34,39	Carnitine_palmitoyltransferase_I	0,32	CPT I	Carnitine palmitoyltransferase I	399528(Tax:9823)	399528(Tax:9823)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Carnitine_palmitoyltransferase_I -LRB- CPT_I -RRB- activity and its regulation by malonyl-CoA are modulated by age and cold exposure in skeletal muscle mitochondria from newborn pigs .
18521119	0	CPT_I	165,170	carnitine_palmitoyltransferase_I	131,163	CPT I	carnitine palmitoyltransferase I	36109(Tax:7227)	36109(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations of the withered -LRB- whd -RRB- gene in Drosophila_melanogaster confer hypersensitivity_to_oxidative_stress and are lesions of the carnitine_palmitoyltransferase_I -LRB- CPT_I -RRB- gene .
26340515	0	CPU	37,40	carboxypeptidase_U	17,35	CPU	carboxypeptidase U	1361	1361	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of carboxypeptidase_U -LRB- CPU , CPB2 or TAFIa -RRB- are elevated in patients with acute_myocardial_infarction .
10073577	0	CPX-1	24,29	CPX-2	116,121	CPX-1	CPX-2	56264(Tax:10090)	55987(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of mouse CPX-1 , a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2 .
10073577	0	CPX-2	116,121	CPX-1	24,29	CPX-2	CPX-1	55987(Tax:10090)	56264(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of mouse CPX-1 , a novel member of the metallocarboxypeptidase gene family with highest similarity to CPX-2 .
10528211	0	CR1	35,38	C1q	0,3	CR1	C1q	1378	712	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	C1q and C4b bind simultaneously to CR1 and additively support erythrocyte adhesion .
10469246	0	CR1	27,30	C3b	81,84	CR1	C3b	1378	718	Gene	Gene	Co-operation|nmod|START_ENTITY Co-operation|nmod|internalization internalization|nmod|END_ENTITY	Co-operation between human CR1 -LRB- CD35 -RRB- and CR2 -LRB- CD21 -RRB- in internalization of their C3b and iC3b ligands by murine-transfected fibroblasts .
11955431	0	CR1	37,40	C3b	17,20	CR1	C3b	1378	718	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Structure of the C3b binding site of CR1 -LRB- CD35 -RRB- , the immune adherence receptor .
18717995	0	CR1	50,53	C3b	24,27	CR1	C3b	1378	100862689	Gene	Gene	deposition|nmod|START_ENTITY deposition|nmod|END_ENTITY	Increased deposition of C3b on red cells with low CR1 and CD55 in a malaria-endemic region of western Kenya : implications for the development of severe anemia .
2138950	0	CR1	40,43	C3b	33,36	CR1	C3b	1378	718	Gene	Gene	B|compound|START_ENTITY END_ENTITY|nmod|B	Competition for binding sites on C3b by CR1 , CR2 , MCP , factor B and factor_H .
2141838	0	CR1	83,86	C3b	183,186	CR1	C3b	1378	718	Gene	Gene	receptor|appos|START_ENTITY have|nsubj|receptor have|dobj|optima optima|nmod|cleavage cleavage|nmod|END_ENTITY	Regulation of proteolytic activity of complement factor I by pH : C3b/C4b _ receptor -LRB- CR1 -RRB- and membrane_cofactor_protein -LRB- MCP -RRB- have different pH optima for factor I-mediated cleavage of C3b .
2527811	0	CR1	62,65	C3b	47,50	CR1	C3b	1378	718	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Interaction between C3 and IL-2 ; inhibition of C3b binding to CR1 by IL-2 .
26415566	0	CR1	145,148	C3b	58,61	CR1	C3b	1378	718	Gene	Gene	studies|nmod|START_ENTITY studies|nmod|cycle cycle|amod|down-regulation down-regulation|nmod|I I|nmod|feedback feedback|amod|END_ENTITY	Further studies of the down-regulation by Factor I of the C3b feedback cycle using endotoxin as a soluble activator and red cells as a source of CR1 on sera of different complotype .
2965698	0	CR1	82,85	C3b	31,34	CR1	C3b	1378	718	Gene	Gene	1|appos|START_ENTITY type|dep|1 Interaction|dep|type Interaction|nmod|END_ENTITY	Interaction of human monomeric C3b with its receptor -LRB- complement receptor type 1 , CR1 -RRB- on neutrophils .
2972794	0	CR1	88,91	C3b	27,30	CR1	C3b	1378	718	Gene	Gene	receptor|appos|START_ENTITY _|dobj|receptor _|nsubj|Identification Identification|nmod|END_ENTITY	Identification of distinct C3b and C4b recognition sites in the human C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- by deletion mutagenesis .
4020137	0	CR1	61,64	C3b	66,69	CR1	C3b	1378	718	Gene	Gene	START_ENTITY|dep|receptors receptors|amod|END_ENTITY	Disease-associated loss of erythrocyte complement receptors -LRB- CR1 , C3b receptors -RRB- in patients with systemic_lupus_erythematosus and other diseases involving autoantibodies and/or complement activation .
7033372	0	CR1	40,43	C3b	58,61	CR1	C3b	1378	718	Gene	Gene	Assay|appos|START_ENTITY Assay|nmod|microspheres microspheres|amod|END_ENTITY	Assay of membrane complement receptors -LRB- CR1 and CR2 -RRB- with C3b - and C3d-coated fluorescent microspheres .
7175439	0	CR1	39,42	C3b	65,68	CR1	C3b	1378	718	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	Unique role of the complement receptor CR1 in the degradation of C3b associated with immune complexes .
8144890	0	CR1	54,57	C3b	11,14	CR1	C3b	12902(Tax:10090)	718	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of C3b and C4b by the CR1-like site in murine CR1 .
2141826	0	CR1	69,72	C3b_receptor	55,67	CR1	C3b receptor	1378	1378	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of chemotactic peptide f-Met-Leu-Phe -LRB- FMLP -RRB- on C3b_receptor -LRB- CR1 -RRB- expression and phagocytosis of microspheres by human neutrophils .
2429332	0	CR1	48,51	C3b_receptor	34,46	CR1	C3b receptor	1378	1378	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	15-HETE `` modulates '' expression of C3b_receptor -LRB- CR1 -RRB- antigen on peripheral blood B-lymphocytes .
2940981	0	CR1	36,39	C3b_receptor	22,34	CR1	C3b receptor	1378	1378	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Relationships between C3b_receptor -LRB- CR1 -RRB- activity of erythrocytes and positive Coombs ' tests .
2954207	0	CR1	37,40	C3b_receptor	23,35	CR1	C3b receptor	1378	1378	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Erythrocyte complement C3b_receptor -LRB- CR1 -RRB- levels and immune complex-induced manifestations in patients with primary Sj __ gren 's _ syndrome .
2955969	0	CR1	14,17	C3b_receptor	0,12	CR1	C3b receptor	1378	1378	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	C3b_receptor -LRB- CR1 -RRB- expression on the polymorphonuclear leukocytes from patients with systemic_lupus_erythematosus .
8595925	0	CR1	94,97	C3b_receptor	37,49	CR1	C3b receptor	1378	1378	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Hind III genomic polymorphism of the C3b_receptor -LRB- CR1 -RRB- in patients with SLE : low erythrocyte CR1 expression is an acquired phenomenon .
12667215	0	CR1	2,5	C4b	90,93	CR1	C4b	1378	721	Gene	Gene	polymorphism|compound|START_ENTITY affects|nsubj|polymorphism affects|xcomp|binding binding|nmod|END_ENTITY	A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b .
12667215	0	CR1	60,63	C4b	90,93	CR1	C4b	1378	721	Gene	Gene	levels|compound|START_ENTITY associated|nmod|levels polymorphism|acl|associated affects|nsubj|polymorphism affects|xcomp|binding binding|nmod|END_ENTITY	A CR1 polymorphism associated with constitutive erythrocyte CR1 levels affects binding to C4b but not C3b .
1386357	0	CR1	102,105	C4b	52,55	CR1	C4b	1378	721	Gene	Gene	receptor|appos|START_ENTITY pathway|nmod|receptor inactivation|nmod|pathway inactivation|nmod|END_ENTITY	Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- and membrane_cofactor_protein -LRB- MCP , CD46 -RRB- .
2430040	0	CR1	67,70	C4b	15,18	CR1	C4b	1378	721	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Membrane-bound C4b interacts endogenously with complement receptor CR1 of human red cells .
8757632	0	CR1	79,82	C4b	59,62	CR1	C4b	449643(Tax:9598)	462577(Tax:9598)	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Substitution of two amino_acids confers C3b binding to the C4b binding site of CR1 -LRB- CD35 -RRB- .
1671871	0	CR1	29,32	CD35	34,38	CR1	CD35	1378	1378	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Genomic determination of the CR1 -LRB- CD35 -RRB- density polymorphism on erythrocytes using polymerase chain reaction amplification and HindIII restriction enzyme digestion .
2402120	0	CR1	14,17	CD35	19,23	CR1	CD35	1378	1378	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of CR1 -LRB- CD35 -RRB- mRNA in podocytes from adult and fetal human kidneys .
1839374	0	CR1	120,123	CD4	84,87	CR1	CD4	1378	920	Gene	Gene	express|dep|START_ENTITY cells|amod|express cells|amod|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression on peripheral T lymphocytes : both CD4 - and CD8-positive cells express CR1 .
1839374	0	CR1	28,31	CD4	84,87	CR1	CD4	1378	920	Gene	Gene	expression|appos|START_ENTITY expression|dep|cells cells|amod|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression on peripheral T lymphocytes : both CD4 - and CD8-positive cells express CR1 .
7682158	0	CR1	0,3	CD4	141,144	CR1	CD4	1378	920	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	CR1 -LRB- CD35 -RRB- and CR3 -LRB- CD11b/CD18 -RRB- mediate infection of human monocytes and monocytic cell lines with complement-opsonized HIV independently of CD4 .
8918576	0	CR1	12,15	CD4	40,43	CR1	CD4	1378	920	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Ligation of CR1 -LRB- C3b receptor , CD35 -RRB- on CD4 + T lymphocytes enhances viral replication in HIV-infected cells .
2144008	0	CR1	14,17	CR2	55,58	CR1	CR2	1378	1380	Gene	Gene	exons|amod|START_ENTITY exons|nmod|transcripts transcripts|compound|END_ENTITY	Loss of human CR1 - and murine Crry-like exons in human CR2 transcripts due to CR2 gene mutations .
2144008	0	CR1	14,17	CR2	78,81	CR1	CR2	1378	1380	Gene	Gene	exons|amod|START_ENTITY Loss|nmod|exons Loss|amod|due due|nmod|mutations mutations|compound|END_ENTITY	Loss of human CR1 - and murine Crry-like exons in human CR2 transcripts due to CR2 gene mutations .
2524204	0	CR1	62,65	CR2	96,99	CR1	CR2	1378	1380	Gene	Gene	erythrocyte|dep|START_ENTITY receptors|amod|erythrocyte processed|nmod|receptors processed|nmod|receptors receptors|compound|END_ENTITY	Enhanced binding of immune complexes processed by erythrocyte CR1 -LRB- CD_35 -RRB- receptors to purified CR2 -LRB- CD_21 -RRB- receptors from tonsillar mononuclear cells .
2941021	0	CR1	46,49	CR2	73,76	CR1	CR2	1378	1380	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Decreased expression of the C3b/C4b _ receptor -LRB- CR1 -RRB- and the C3d_receptor -LRB- CR2 -RRB- on B lymphocytes and of CR1 on neutrophils of patients with systemic_lupus_erythematosus .
2989379	0	CR1	36,39	CR2	50,53	CR1	CR2	1378	1380	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Human complement receptors for C3b -LRB- CR1 -RRB- and C3d -LRB- CR2 -RRB- .
2148644	0	CR1	52,55	CR3	67,70	CR1	CR3	1378	6998	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Phagocytosis of agarose beads by receptors for C3b -LRB- CR1 -RRB- and iC3b -LRB- CR3 -RRB- on alveolar macrophages from patients with sarcoidosis .
2948272	0	CR1	52,55	CR3	67,70	CR1	CR3	1378	6998	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Phagocytosis of agarose beads by receptors for C3b -LRB- CR1 -RRB- and iC3b -LRB- CR3 -RRB- on human alveolar macrophages cultured on fibronectin in vitro .
6242391	1	CR1	95,98	CR3	110,113	CR1	CR3	1378	6998	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Independent function of receptors for C3b -LRB- CR1 -RRB- and iC3b -LRB- CR3 -RRB- .
1839374	0	CR1	28,31	Complement_receptor_type_1	0,26	CR1	Complement receptor type 1	1378	1378	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression on peripheral T lymphocytes : both CD4 - and CD8-positive cells express CR1 .
1386357	0	CR1	102,105	MCP	144,147	CR1	MCP	1378	4179	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- and membrane_cofactor_protein -LRB- MCP , CD46 -RRB- .
8706338	0	CR1	51,54	complement_receptor_1	28,49	CR1	complement receptor 1	1378	1378	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Structural polymorphisms of complement_receptor_1 -LRB- CR1 -RRB- in systemic_lupus_erythematosus -LRB- SLE -RRB- patients and normal controls of three ethnic groups .
10786621	0	CR1	79,82	complement_receptor_type_1	51,77	CR1	complement receptor type 1	1378	1378	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter activity of the 5 ' flanking region of the complement_receptor_type_1 -LRB- CR1 -RRB- gene : basal and induced transcription .
11811640	0	CR1	42,45	complement_receptor_type_1	14,40	CR1	complement receptor type 1	1378	1378	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of complement_receptor_type_1 -LRB- CR1 -RRB- on erythrocytes of paracoccidiodomycosis patients .
16305660	0	CR1	44,47	complement_receptor_type_1	16,42	CR1	complement receptor type 1	1378	1378	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Low erythrocyte complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression in preeclamptic gestations .
2573360	0	CR1	45,48	complement_receptor_type_1	17,43	CR1	complement receptor type 1	1378	1378	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The frequency of complement_receptor_type_1 -LRB- CR1 -RRB- gene polymorphisms in nine families with multiple cases of systemic_lupus_erythematosus .
9614933	0	CR1	40,43	complement_receptor_type_1	12,38	CR1	complement receptor type 1	1378	1378	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of complement_receptor_type_1 -LRB- CR1 -RRB- expression on erythrocytes and of CR1 allelic markers in Caucasian and African American populations .
9950773	0	CR1	58,61	complement_receptor_type_1	30,56	CR1	complement receptor type 1	1378	1378	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Hypoxia-induced expression of complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- in human vascular endothelial cells .
11466369	0	CR2	63,66	C3d	91,94	CR2	C3d	1380	100861467	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Kinetic analysis of the interactions of complement_receptor_2 -LRB- CR2 , CD21 -RRB- with its ligands C3d , iC3b , and the EBV glycoprotein gp350/220 .
1323059	0	CR2	61,64	C3d	47,50	CR2	C3d	1380	100861467	Gene	Gene	localization|appos|START_ENTITY localization|nmod|receptor receptor|amod|END_ENTITY	Nuclear localization of the Epstein-Barr_virus / C3d receptor -LRB- CR2 -RRB- in the human Burkitt B lymphoma cell , Raji .
25433434	0	CR2	30,33	C3d	26,29	CR2	C3d	1380	100861467	Gene	Gene	view|dep|START_ENTITY view|nmod|END_ENTITY	A theoretical view of the C3d : CR2 binding controversy .
2557614	0	CR2	53,56	C3d	39,42	CR2	C3d	1380	100861467	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Epstein-Barr_virus / complement fragment C3d receptor -LRB- CR2 -RRB- reacts with p53 , a cellular antioncogene-encoded membrane phosphoprotein : detection by polyclonal anti-idiotypic anti-CR2 antibodies .
27092816	0	CR2	39,42	C3d	35,38	CR2	C3d	1380	100861467	Gene	Gene	Association|compound|START_ENTITY END_ENTITY|dep|Association	Electrostatic Steering Accelerates C3d : CR2 Association .
3009615	0	CR2	63,66	C3d	49,52	CR2	C3d	1380	100861467	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Incorporation of the purified Epstein_Barr_virus / C3d receptor -LRB- CR2 -RRB- into liposomes and demonstration of its dual ligand binding functions .
7589142	0	CR2	33,36	C3d	19,22	CR2	C3d	1380	100861467	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Epstein-Barr_virus / C3d receptor -LRB- CR2 , CD21 -RRB- activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways .
2971638	0	CR2	14,17	C3d_receptor	19,31	CR2	C3d receptor	1380	1380	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CR2 -LRB- C3d_receptor -RRB- on the cell membranes of adult_T_cell_leukemia .
1688740	0	CR2	4,7	CD21	18,22	CR2	CD21	1380	1380	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The CR2 receptor -LRB- CD21 -RRB- shows increased expression in the more differentiated cells of an antigen-specific B cell line .
1835941	0	CR2	34,37	CD21	39,43	CR2	CD21	1380	1380	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of complement receptor CR2 -LRB- CD21 -RRB- on human subcorneal keratinocytes in normal and diseased skin .
20394560	0	CR2	92,95	CD21	97,101	CR2	CD21	1380	1380	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	The Splenic White Pulp in Chronic_Lymphocytic_Leukaemia : A Microenvironment Associated with CR2 -LRB- CD21 -RRB- Expression , Cell Transformation and Proliferation .
2524204	0	CR2	96,99	CD_21	101,106	CR2	CD 21	1380	1380	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Enhanced binding of immune complexes processed by erythrocyte CR1 -LRB- CD_35 -RRB- receptors to purified CR2 -LRB- CD_21 -RRB- receptors from tonsillar mononuclear cells .
2144008	0	CR2	55,58	CR1	14,17	CR2	CR1	1380	1378	Gene	Gene	transcripts|compound|START_ENTITY exons|nmod|transcripts exons|amod|END_ENTITY	Loss of human CR1 - and murine Crry-like exons in human CR2 transcripts due to CR2 gene mutations .
2144008	0	CR2	78,81	CR1	14,17	CR2	CR1	1380	1378	Gene	Gene	mutations|compound|START_ENTITY due|nmod|mutations Loss|amod|due Loss|nmod|exons exons|amod|END_ENTITY	Loss of human CR1 - and murine Crry-like exons in human CR2 transcripts due to CR2 gene mutations .
2524204	0	CR2	96,99	CR1	62,65	CR2	CR1	1380	1378	Gene	Gene	receptors|compound|START_ENTITY processed|nmod|receptors processed|nmod|receptors receptors|amod|erythrocyte erythrocyte|dep|END_ENTITY	Enhanced binding of immune complexes processed by erythrocyte CR1 -LRB- CD_35 -RRB- receptors to purified CR2 -LRB- CD_21 -RRB- receptors from tonsillar mononuclear cells .
2941021	0	CR2	73,76	CR1	46,49	CR2	CR1	1380	1378	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Decreased expression of the C3b/C4b _ receptor -LRB- CR1 -RRB- and the C3d_receptor -LRB- CR2 -RRB- on B lymphocytes and of CR1 on neutrophils of patients with systemic_lupus_erythematosus .
2989379	0	CR2	50,53	CR1	36,39	CR2	CR1	1380	1378	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Human complement receptors for C3b -LRB- CR1 -RRB- and C3d -LRB- CR2 -RRB- .
1321787	0	CR2	98,101	EBV_receptor	103,115	CR2	EBV receptor	1380	1380	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Epstein-Barr_virus DNA in Reed-Sternberg cells of Hodgkin 's _ disease is frequently associated with CR2 -LRB- EBV_receptor -RRB- expression .
7957570	0	CR2	14,17	complement_C3	24,37	CR2	complement C3	1380	718	Gene	Gene	START_ENTITY|dep|receptors receptors|amod|END_ENTITY	CR1 -LRB- CD35 -RRB- and CR2 -LRB- CD21 -RRB- complement_C3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus .
1706386	0	CR2	53,56	complement_receptor_2	30,51	CR2	complement receptor 2	1380	1380	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Characterization of the human complement_receptor_2 -LRB- CR2 , CD21 -RRB- promoter reveals sequences shared with regulatory regions of other developmentally restricted B cell proteins .
11091285	0	CR2	54,57	complement_receptor_type_2	26,52	CR2	complement receptor type 2	1380	1380	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of the complement_receptor_type_2 -LRB- CR2 , CD21 -RRB- by synovial fluid B and T lymphocytes .
1825940	0	CR2	52,55	complement_receptor_type_2	24,50	CR2	complement receptor type 2	1380	1380	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of complement_receptor_type_2 -LRB- CR2 -RRB- on neoplastic B cells of chronic_lymphocytic_leukaemia .
9570543	0	CR2	121,124	complement_receptor_type_2	93,119	CR2	complement receptor type 2	1380	1380	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An intronic silencer regulates B lymphocyte cell - and stage-specific expression of the human complement_receptor_type_2 -LRB- CR2 , CD21 -RRB- gene .
2148644	0	CR3	67,70	CR1	52,55	CR3	CR1	6998	1378	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Phagocytosis of agarose beads by receptors for C3b -LRB- CR1 -RRB- and iC3b -LRB- CR3 -RRB- on alveolar macrophages from patients with sarcoidosis .
2948272	0	CR3	67,70	CR1	52,55	CR3	CR1	6998	1378	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Phagocytosis of agarose beads by receptors for C3b -LRB- CR1 -RRB- and iC3b -LRB- CR3 -RRB- on human alveolar macrophages cultured on fibronectin in vitro .
6242391	1	CR3	110,113	CR1	95,98	CR3	CR1	6998	1378	Gene	Gene	C3b|appos|START_ENTITY C3b|appos|END_ENTITY	Independent function of receptors for C3b -LRB- CR1 -RRB- and iC3b -LRB- CR3 -RRB- .
1709677	0	CR3	97,100	Endothelial-leukocyte_adhesion_molecule_1	0,41	CR3	Endothelial-leukocyte adhesion molecule 1	6998	6401	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Endothelial-leukocyte_adhesion_molecule_1 stimulates the adhesive activity of leukocyte integrin CR3 -LRB- CD11b/CD18 , Mac-1 , _ alpha_m_beta_2 -RRB- on human neutrophils .
7515890	0	CR3	0,3	Fc_gamma_RIII	133,146	CR3	Fc gamma RIII	6998	2214	Gene	Gene	START_ENTITY|dep|requirement requirement|nmod|END_ENTITY	CR3 -LRB- Mac-1 , _ alpha_M_beta_2 , CD11b/CD18 -RRB- and Fc_gamma_RIII cooperate in generation of a neutrophil respiratory burst : requirement for Fc_gamma_RIII and tyrosine phosphorylation .
26210498	0	CR6-interacting_factor_1	65,89	Lymphocyte-specific_protein_tyrosine_kinase	0,43	CR6-interacting factor 1	Lymphocyte-specific protein tyrosine kinase	90480	3932	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- interacts with CR6-interacting_factor_1 -LRB- CRIF1 -RRB- in mitochondria to repress oxidative phosphorylation .
26210498	0	CR6-interacting_factor_1	65,89	Lymphocyte-specific_protein_tyrosine_kinase	0,43	CR6-interacting factor 1	Lymphocyte-specific protein tyrosine kinase	90480	3932	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- interacts with CR6-interacting_factor_1 -LRB- CRIF1 -RRB- in mitochondria to repress oxidative phosphorylation .
20427290	0	CR6-interacting_factor_1	0,24	NF-E2-related_factor_2	43,65	CR6-interacting factor 1	NF-E2-related factor 2	90480	4780	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	CR6-interacting_factor_1 -LRB- CRIF1 -RRB- regulates NF-E2-related_factor_2 -LRB- NRF2 -RRB- protein stability by proteasome-mediated degradation .
15459248	0	CR6-interacting_factor_1	0,24	Nur77	64,69	CR6-interacting factor 1	Nur77	90480	3164	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CR6-interacting_factor_1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation .
7815831	0	CRABP	96,101	cellular_retinoic_acid_binding_protein	56,94	CRABP	cellular retinoic acid binding protein	1381	1381	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	In vitro all-trans_retinoic_acid -LRB- ATRA -RRB- sensitivity and cellular_retinoic_acid_binding_protein -LRB- CRABP -RRB- levels in relapse leukemic cells after remission induction by ATRA in acute_promyelocytic_leukemia .
8207983	0	CRABP	96,101	cellular_retinoic_acid_binding_protein	56,94	CRABP	cellular retinoic acid binding protein	1381	1381	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	In vitro all-trans_retinoic_acid -LRB- ATRA -RRB- sensitivity and cellular_retinoic_acid_binding_protein -LRB- CRABP -RRB- levels in relapse leukemic cells after remission induction by ATRA in acute_promyelocytic_leukemia .
18955045	0	CRABP-II	14,22	MycN	37,41	CRABP-II	MycN	1382	4613	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of CRABP-II expression by MycN in Wilms_tumor .
12628590	0	CRABP-II	113,121	cellular_retinoic_acid_binding_protein_II	65,106	CRABP-II	cellular retinoic acid binding protein II	1382	1382	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two novel single nucleotide polymorphisms in the promoter of the cellular_retinoic_acid_binding_protein_II gene -LRB- CRABP-II -RRB- .
11682061	0	CRABPII	23,30	RARalpha	40,48	CRABPII	RARalpha	1382	5914	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The novel co-activator CRABPII binds to RARalpha and RXRalpha via two nuclear receptor interacting domains and does not require the AF-2 ` core ' .
1351399	0	CRABP_I	53,60	cellular_retinoic_acid-binding_protein_I	11,51	CRABP I	cellular retinoic acid-binding protein I	12903(Tax:10090)	12903(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Domains of cellular_retinoic_acid-binding_protein_I -LRB- CRABP_I -RRB- expression in the hindbrain and neural crest of the mouse embryo .
9704013	0	CRABP_II	54,62	cellular_retinoic_acid_binding_protein	14,52	CRABP II	cellular retinoic acid binding protein	1382	1382	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cellular_retinoic_acid_binding_protein -LRB- CRABP_II -RRB- during human monocyte differentiation in vitro .
16339536	0	CRACC	26,31	EAT-2	48,53	CRACC	EAT-2	57823	117157	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The cytotoxicity receptor CRACC -LRB- CS-1 -RRB- recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells .
17018604	0	CRAF	79,83	BRAF	71,75	CRAF	BRAF	5894	673	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	In melanoma , RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic_AMP signaling .
21229300	0	CRALBP	21,27	RPE65	14,19	CRALBP	RPE65	6017	6121	Gene	Gene	CD68|appos|START_ENTITY CD68|compound|END_ENTITY	Evaluation of RPE65 , CRALBP , VEGF , CD68 , and tyrosinase gene expression in human retinal pigment epithelial cells cultured on amniotic membrane .
18839069	0	CRAT	38,42	carnitine_acetyltransferase	4,31	CRAT	carnitine acetyltransferase	1384	1384	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The carnitine_acetyltransferase gene -LRB- CRAT -RRB- : a characterization of porcine transcripts with insights into the 5 ' - end variants of mammalian transcripts and their possible sub-cellular localization .
11389483	0	CRB1	148,152	crumbs_homologue_1	128,146	CRB1	crumbs homologue 1	23418	23418	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Leber_congenital_amaurosis and retinitis_pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs_homologue_1 -LRB- CRB1 -RRB- gene .
15851977	0	CRB2	42,46	Crumbs_homolog_2	24,40	CRB2	Crumbs homolog 2	286204	286204	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the Crumbs_homolog_2 -LRB- CRB2 -RRB- gene and analysis of its role in retinitis_pigmentosa and Leber_congenital_amaurosis .
14718572	0	CRB3	0,4	Par6	23,27	CRB3	Par6	92359	100506965	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells .
26909574	0	CRBN	70,74	CRL4	65,69	CRBN	CRL4	51185	55540	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Structural basis of lenalidomide-induced CK1a degradation by the CRL4 -LRB- CRBN -RRB- ubiquitin ligase .
26900151	0	CRBP1	91,96	Cellular_Retinol-Binding_Protein_1	55,89	CRBP1	Cellular Retinol-Binding Protein 1	5947	5947	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Ligand Binding Induces Conformational Changes in Human Cellular_Retinol-Binding_Protein_1 -LRB- CRBP1 -RRB- revealed by atomic resolution crystal structures .
22833659	0	CRBP2	67,72	CETP	74,78	CRBP2	CETP	5948	1071	Gene	Gene	polymorphisms|nmod|START_ENTITY END_ENTITY|nsubj|polymorphisms	Gender and single nucleotide polymorphisms in MTHFR , BHMT , SPTLC1 , CRBP2 , CETP , and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults .
7516425	0	CRBP_I	55,61	cellular_retinol-binding_protein_I	19,53	CRBP I	cellular retinol-binding protein I	25056(Tax:10116)	25056(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression of cellular_retinol-binding_protein_I -LRB- CRBP_I -RRB- is affected by dietary proteins in the rat liver .
12461297	0	CRD1	44,48	p300	39,43	CRD1	p300	1319	2033	Gene	Gene	motif|compound|START_ENTITY motif|amod|END_ENTITY	Induction of transcription through the p300 CRD1 motif by p21WAF1/CIP1 is core promoter specific and cyclin dependent kinase independent .
14761884	0	CRE-binding_protein	32,51	Tumor_necrosis_factor	0,21	CRE-binding protein	Tumor necrosis factor	1385	7124	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Tumor_necrosis_factor activates CRE-binding_protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells .
11976688	0	CREB	27,31	AP-1	0,4	CREB	AP-1	39682(Tax:7227)	36057(Tax:7227)	Gene	Gene	upstream|nmod|START_ENTITY upstream|nsubj|functions functions|compound|END_ENTITY	AP-1 functions upstream of CREB to control synaptic plasticity in Drosophila .
24819963	0	CREB	88,92	AP-1	82,86	CREB	AP-1	81646(Tax:10116)	24516(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
20805990	0	CREB	0,4	AP-2alpha	14,23	CREB	AP-2alpha	1385	7020	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma .
11642609	0	CREB	20,24	ATF-1	14,19	CREB	ATF-1	1385	466	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the ATF-1 / CREB transcription factors by single chain Fv fragment in human melanoma : potential modality for cancer therapy .
15531295	0	CREB	76,80	ATF-2	82,87	CREB	ATF-2	12912(Tax:10090)	11909(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Piperine is a potent inhibitor of nuclear factor-kappaB -LRB- NF-kappaB -RRB- , c-Fos , CREB , ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells .
18386196	0	CREB	31,35	ATF-2	24,29	CREB	ATF-2	81646(Tax:10116)	81647(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of activated ATF-2 , CREB and c-Myc in rat colon transversum after whole-body gamma-irradiation and its contribution to pathogenesis and biodosimetry .
8407959	0	CREB	194,198	ATF-2	138,143	CREB	ATF-2	1385	1386	Gene	Gene	response|appos|START_ENTITY response|amod|binding binding|dep|END_ENTITY	Transactivation by the human T-cell_leukemia virus Tax protein is mediated through enhanced binding of activating_transcription_factor-2 -LRB- ATF-2 -RRB- ATF-2 response and cAMP element-binding protein -LRB- CREB -RRB- .
8407959	0	CREB	194,198	ATF-2	145,150	CREB	ATF-2	1385	1386	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Transactivation by the human T-cell_leukemia virus Tax protein is mediated through enhanced binding of activating_transcription_factor-2 -LRB- ATF-2 -RRB- ATF-2 response and cAMP element-binding protein -LRB- CREB -RRB- .
8479741	0	CREB	115,119	ATF-2	125,130	CREB	ATF-2	1385	1386	Gene	Gene	START_ENTITY|nmod|blocks blocks|compound|END_ENTITY	Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2 : interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation .
8479741	0	CREB	84,88	ATF-2	125,130	CREB	ATF-2	1385	1386	Gene	Gene	interactions|nmod|START_ENTITY interactions|dep|interaction interaction|nmod|CREB CREB|nmod|blocks blocks|compound|END_ENTITY	Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2 : interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation .
17276404	0	CREB	27,31	Akt1	35,39	CREB	Akt1	1385	207	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Differential activation of CREB by Akt1 and Akt2 .
26294214	0	CREB	49,53	Akt_Kinase-Interacting_Protein_1	0,32	CREB	Akt Kinase-Interacting Protein 1	1385	54862	Gene	Gene	Signals|nmod|START_ENTITY Signals|nsubj|END_ENTITY	Akt_Kinase-Interacting_Protein_1 Signals through CREB to Drive Diffuse_Malignant_Mesothelioma .
17559081	0	CREB	59,63	Ang_II	0,6	CREB	Ang II	81646(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Ang_II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells .
11704836	0	CREB	2,6	BRCA1	19,24	CREB	BRCA1	1385	672	Gene	Gene	site|compound|START_ENTITY site|nmod|promoter promoter|compound|END_ENTITY	A CREB site in the BRCA1 proximal promoter acts as a constitutive transcriptional element .
19568323	0	CREB	10,14	BRCA1	18,23	CREB	BRCA1	1385	672	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Activity Activity|compound|END_ENTITY	A Role of CREB in BRCA1 Constitutive Promoter Activity and Aromatase Basal Expression .
24819963	0	CREB	88,92	Bax	53,56	CREB	Bax	81646(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
18086876	0	CREB	187,191	Bcl-2	95,100	CREB	Bcl-2	81646(Tax:10116)	24224(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY coordinated|dobj|protein coordinated|nsubjpass|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Glucose-dependent_insulinotropic_polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic_AMP -LRB- cAMP -RRB- response element binding protein -LRB- CREB -RRB- and cAMP-responsive CREB coactivator 2 .
18785877	0	CREB	119,123	Bcl-2	17,22	CREB	Bcl-2	81646(Tax:10116)	24224(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY mediated|nmod|activation mediated|nsubjpass|expression expression|compound|END_ENTITY	Estrogen-induced Bcl-2 expression after spinal_cord_injury is mediated through phosphoinositide-3-kinase / Akt-dependent CREB activation .
19626458	0	CREB	0,4	Bcl-2	39,44	CREB	Bcl-2	1385	596	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	CREB , a possible upstream regulator of Bcl-2 in trichosanthin-induced HeLa cell apoptosis .
20198332	0	CREB	39,43	Bcl-2	19,24	CREB	Bcl-2	1385	596	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|advcl|activating	PKCepsilon induces Bcl-2 by activating CREB .
24819963	0	CREB	88,92	Bcl-2	58,63	CREB	Bcl-2	81646(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
22035109	0	CREB	39,43	Brain-derived_neurotrophic_factor	0,33	CREB	Brain-derived neurotrophic factor	81646(Tax:10116)	24225(Tax:10116)	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons .
10686068	0	CREB	11,15	CA1	63,66	CREB	CA1	81646(Tax:10116)	310218(Tax:10116)	Gene	Gene	phosphorylation|nsubj|START_ENTITY phosphorylation|nmod|protection protection|nmod|pyramidal_neurons pyramidal_neurons|compound|END_ENTITY	Persistent CREB phosphorylation with protection of hippocampal CA1 pyramidal_neurons following temporary occlusion of the middle cerebral artery in the rat .
12887679	0	CREB	0,4	CA1	77,80	CREB	CA1	12912(Tax:10090)	12346(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|acquisition acquisition|nmod|tolerance tolerance|nmod|region region|compound|END_ENTITY	CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region .
17161830	0	CREB	117,121	CA1	145,148	CREB	CA1	81646(Tax:10116)	310218(Tax:10116)	Gene	Gene	element-binding|appos|START_ENTITY expression|nsubj|element-binding expression|nmod|END_ENTITY	Chronic exposure to estrogen and tamoxifen regulates synaptophysin and phosphorylated_cAMP response element-binding -LRB- CREB -RRB- protein expression in CA1 of ovariectomized rat hippocampus .
17303091	0	CREB	14,18	CA1	54,57	CREB	CA1	12912(Tax:10090)	12346(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|region region|compound|END_ENTITY	Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse -LRB- SAM -RRB- P8 .
20848600	0	CREB	36,40	CA1	72,75	CREB	CA1	12912(Tax:10090)	12346(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Extinction of spatial memory alters CREB phosphorylation in hippocampal CA1 .
21734652	0	CREB	11,15	CA1	32,35	CREB	CA1	12912(Tax:10090)	12346(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|nmod|region region|compound|END_ENTITY	Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory_deficits in a mouse model of Alzheimer 's _ disease .
22817531	0	CREB	99,103	CA1	21,24	CREB	CA1	81646(Tax:10116)	310218(Tax:10116)	Gene	Gene	GSK-3b|advmod|START_ENTITY pathways|amod|GSK-3b modulation|nmod|pathways prevents|nmod|modulation prevents|dobj|neurons neurons|nummod|END_ENTITY	Resveratrol prevents CA1 neurons against ischemic_injury by parallel modulation of both GSK-3b and CREB through PI3-K/Akt pathways .
12117553	0	CREB	44,48	CART	0,4	CREB	CART	81646(Tax:10116)	29131(Tax:10116)	Gene	Gene	phosphorylated|dobj|START_ENTITY phosphorylated|nsubj|binds binds|compound|END_ENTITY	CART promoter CRE site binds phosphorylated CREB .
19046951	0	CREB	41,45	CART	14,18	CREB	CART	81646(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo .
20451507	0	CREB	46,50	CART	94,98	CREB	CART	81646(Tax:10116)	29131(Tax:10116)	Gene	Gene	133|amod|START_ENTITY revealed|dobj|133 revealed|nmod|promoter promoter|compound|END_ENTITY	Chromatin immunoprecipitation assays revealed CREB and serine 133 phospho-CREB binding to the CART gene proximal promoter .
16339753	0	CREB	87,91	CBP	129,132	CREB	CBP	1385	1387	Gene	Gene	coactivation|compound|START_ENTITY facilitating|dobj|coactivation facilitating|nmod|END_ENTITY	The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP .
16761278	0	CREB	88,92	CBP	142,145	CREB	CBP	1385	1387	Gene	Gene	domain|nmod|START_ENTITY structure|nmod|domain facilitates|nsubj|structure facilitates|nmod|domain domain|nmod|END_ENTITY	Phosphorylation-induced transient intrinsic structure in the kinase-inducible domain of CREB facilitates its recognition by the KIX domain of CBP .
17476304	0	CREB	69,73	CBP	33,36	CREB	CBP	1385	1387	Gene	Gene	expression|amod|START_ENTITY confer|nmod|expression confer|nsubj|interactions interactions|nmod|END_ENTITY	Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression .
23768074	0	CREB	33,37	CBP	29,32	CREB	CBP	1385	1387	Gene	Gene	contribution|dep|START_ENTITY contribution|nmod|END_ENTITY	Differential contribution of CBP : CREB binding to corticotropin-releasing_hormone expression in the infant and adult hypothalamus .
24338025	0	CREB	27,31	CBP	76,79	CREB	CBP	1385	1387	Gene	Gene	protein|compound|START_ENTITY protein|acl|scaffolded scaffolded|nmod|proteins proteins|appos|END_ENTITY	NF-kB and enhancer-binding CREB protein scaffolded by CREB-binding_protein -LRB- CBP -RRB- / p300 proteins regulate CD59 protein expression to protect cells from complement attack .
8413673	0	CREB	15,19	CBP	62,65	CREB	CBP	1385	1387	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Phosphorylated CREB binds specifically to the nuclear protein CBP .
9413984	0	CREB	83,87	CBP	40,43	CREB	CBP	1385	1387	Gene	Gene	domain|nmod|START_ENTITY bound|nmod|domain structure|amod|bound structure|nmod|domain domain|nmod|END_ENTITY	Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB : a model for activator : coactivator interactions .
18713830	0	CREB	20,24	CCND1	38,43	CREB	CCND1	1385	595	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	VRK1 phosphorylates CREB and mediates CCND1 expression .
12234923	0	CREB	72,76	COX-2	13,18	CREB	COX-2	12912(Tax:10090)	17709(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY regulated|nmod|signals regulated|nsubjpass|Induction Induction|nmod|END_ENTITY	Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals .
17559081	0	CREB	59,63	COX-2	38,43	CREB	COX-2	81646(Tax:10116)	26198(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Ang_II and EGF synergistically induce COX-2 expression via CREB in intestinal epithelial cells .
18355441	0	CREB	68,72	COX-2	15,20	CREB	COX-2	1385	4513	Gene	Gene	phosphorylation|nmod|START_ENTITY monocytes|nmod|phosphorylation regulates|nmod|monocytes regulates|dobj|expression expression|compound|END_ENTITY	DPPC regulates COX-2 expression in monocytes via phosphorylation of CREB .
21268077	0	CREB	137,141	COX-2	27,32	CREB	COX-2	1385	5743	Gene	Gene	signaling|compound|START_ENTITY modulates|parataxis|signaling modulates|dep|END_ENTITY	Enterovirus 71 modulates a COX-2 / PGE2/cAMP-dependent viral replication in human neuroblastoma cells : role of the c-Src/EGFR/p42 / p44_MAPK / CREB signaling pathway .
25423567	0	CREB	99,103	COX-2	29,34	CREB	COX-2	1385	5743	Gene	Gene	Pathway|compound|START_ENTITY cGMP|nmod|Pathway cGMP|dobj|Expression Expression|compound|END_ENTITY	Nitric_Oxide and cGMP Induce COX-2 Expression and PGE2 Production in Human Granulosa Cells Through CREB Signaling Pathway .
12111373	0	CREB	88,92	CREB4	101,106	CREB	CREB4	1385	148327	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of a novel human cAMP response element-binding -LRB- CREB -RRB- gene -LRB- CREB4 -RRB- .
10848610	0	CREB	72,76	CREB_binding_protein	19,39	CREB	CREB binding protein	1385	1387	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	p53 recruitment of CREB_binding_protein mediated through phosphorylated CREB : a novel pathway of tumor suppressor regulation .
12810819	0	CREB	46,50	Calcium-independent_phospholipase_A2	0,36	CREB	Calcium-independent phospholipase A2	281713(Tax:9913)	282438(Tax:9913)	Gene	Gene	phosphorylation|compound|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Calcium-independent_phospholipase_A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells .
21819464	0	CREB	56,60	Corticotropin-releasing_factor	0,30	CREB	Corticotropin-releasing factor	81646(Tax:10116)	81648(Tax:10116)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Corticotropin-releasing_factor and urocortin_I activate CREB through functionally selective Gby signaling in hippocampal pyramidal neurons .
16819137	0	CREB	52,56	Cyclic_nucleotide_Response_Element_Binding_protein	0,50	CREB	Cyclic nucleotide Response Element Binding protein	1385	1385	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Cyclic_nucleotide_Response_Element_Binding_protein -LRB- CREB -RRB- activation promotes survival signal in human K562 erythroleukemia cells exposed to ionising radiation/etoposide combined treatment .
11880483	0	CREB	136,140	ERK	110,113	CREB	ERK	1385	5594	Gene	Gene	coupled|nmod|START_ENTITY activation|acl|coupled activation|compound|END_ENTITY	Brain-derived_neurotrophic_factor induces long-term potentiation in intact adult hippocampus : requirement for ERK activation coupled to CREB and upregulation of Arc synthesis .
12540838	0	CREB	91,95	ERK	11,14	CREB	ERK	1385	5594	Gene	Gene	activity|appos|START_ENTITY regulates|dobj|activity regulates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Persistent ERK phosphorylation negatively regulates cAMP_response_element-binding_protein -LRB- CREB -RRB- activity via recruitment of CREB-binding_protein to pp90RSK .
16678346	0	CREB	23,27	ERK	9,12	CREB	ERK	1385	5594	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Enhanced ERK dependent CREB activation reduces apoptosis in staurosporine-treated human neuroblastoma SK-N-BE -LRB- 2 -RRB- C cells .
26424114	0	CREB	134,138	ERK	112,115	CREB	ERK	81646(Tax:10116)	24338(Tax:10116)	Gene	Gene	induce|dobj|START_ENTITY proceed|xcomp|induce proceed|nmod|END_ENTITY	FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation .
18329727	0	CREB	80,84	ERK1/2	45,51	CREB	ERK1/2	81646(Tax:10116)	50689;116590	Gene	Gene	START_ENTITY|nsubj|level level|nmod|END_ENTITY	Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture .
22867433	0	CREB	9,13	FMRP	35,39	CREB	FMRP	12912(Tax:10090)	14265(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|regulation regulation|nmod|END_ENTITY	Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex .
25379405	0	CREB	0,4	GLP-1	63,68	CREB	GLP-1	12912(Tax:10090)	14526(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse b-cells .
27035653	0	CREB	129,133	GLP-1_Receptor	100,114	CREB	GLP-1 Receptor	1385	2740	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Long-term Exposure of Pancreatic Beta-Cells to Palmitate Results in SREBP-1C-dependent Decreases in GLP-1_Receptor Signaling via CREB and AKT and Insulin Secretory Response .
27049759	0	CREB	28,32	GSK-3a	0,6	CREB	GSK-3a	1385	2931	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	GSK-3a Is a Novel Target of CREB and CREB-GSK-3a Signaling Participates in Cell Viability in Lung_Cancer .
21549192	0	CREB	7,11	GSK-3b	0,6	CREB	GSK-3b	1385	2932	Gene	Gene	axis|compound|START_ENTITY mediates|nsubj|axis END_ENTITY|parataxis|mediates	GSK-3b / CREB axis mediates IGF-1-induced ECM/adhesion molecule expression , cell cycle progression and monolayer permeability in retinal capillary endothelial cells : Implications for diabetic_retinopathy .
23266915	0	CREB	85,89	GSK-3b	133,139	CREB	GSK-3b	81646(Tax:10116)	84027(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Pretreatment of PC12 cells with 17b-estradiol prevents Ab-induced down-regulation of CREB phosphorylation and prolongs inhibition of GSK-3b .
15155564	0	CREB	93,97	GSK3beta	112,120	CREB	GSK3beta	1385	2932	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Reoxygenation after severe hypoxia induces cardiomyocyte_hypertrophy in vitro : activation of CREB downstream of GSK3beta .
10074179	0	CREB	25,29	Gli2	15,19	CREB	Gli2	1385	2736	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human_T-cell_leukemia_virus_type_1 is responsible for transcriptional activation by tax protein .
16168389	0	CREB	79,83	IGF-1	0,5	CREB	IGF-1	1385	3479	Gene	Gene	apoptosis|nmod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB .
19718656	0	CREB	55,59	IL-4	42,46	CREB	IL-4	1385	3565	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of MUC5AC gene expression by IL-4 through CREB in human airway epithelial cells .
20160059	0	CREB	119,123	IL-6	59,63	CREB	IL-6	1385	3569	Gene	Gene	activating|nmod|START_ENTITY activating|dobj|STAT3 STAT3|compound|END_ENTITY	ZIP4 regulates pancreatic_cancer cell growth by activating IL-6 / STAT3 pathway through zinc finger transcription factor CREB .
23825534	0	CREB	58,62	IL-6	0,4	CREB	IL-6	81646(Tax:10116)	24498(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt / CREB signaling pathway in hepatocytes : implication of an anti-apoptotic role during liver_regeneration .
26473326	0	CREB	52,56	Interleukin-1b	79,93	CREB	Interleukin-1b	81646(Tax:10116)	24494(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Long-Lasting Activation of the Transcription Factor CREB in Sensory Neurons by Interleukin-1b During Antigen-Induced Arthritis in Rats : A Mechanism of Persistent Arthritis Pain ?
26964565	0	CREB	71,75	MALAT1	20,26	CREB	MALAT1	1385	378938	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|nsubj|END_ENTITY	Long non-coding RNA MALAT1 regulates retinal_neurodegeneration through CREB signaling .
17712720	0	CREB	45,49	MC2-R	20,25	CREB	MC2-R	1385	4158	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of human MC2-R gene expression by CREB , CREM , and ICER in the adrenocortical cell line Y1 .
24819963	0	CREB	88,92	NFk-B	75,80	CREB	NFk-B	81646(Tax:10116)	81736(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
18625910	0	CREB	51,55	P2RX7	24,29	CREB	P2RX7	1385	5027	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells .
26944191	0	CREB	101,105	PAI-1	144,149	CREB	PAI-1	1385	5054	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	MnTE-2-PyP_reduces_prostate_cancer growth and metastasis by suppressing p300 activity and p300/HIF -1 / CREB binding to the promoter region of the PAI-1 gene .
16449647	0	CREB	88,92	PEN-2	30,35	CREB	PEN-2	1385	55851	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of PEN-2 , a key component of the gamma-secretase complex , by CREB .
11557984	0	CREB	0,4	PGC-1	63,68	CREB	PGC-1	12912(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 .
12107181	0	CREB	196,200	PGC-1	16,21	CREB	PGC-1	1385	10891	Gene	Gene	HNF4_alpha|appos|START_ENTITY involved|nmod|HNF4_alpha involved|nsubjpass|END_ENTITY	The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4_alpha and cAMP-response_element-binding_protein -LRB- CREB -RRB- .
14614508	0	CREB	0,4	PPAR-gamma	72,82	CREB	PPAR-gamma	12912(Tax:10090)	19016(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma .
22570239	0	CREB	55,59	Polycystin-1	0,12	CREB	Polycystin-1	12912(Tax:10090)	18763(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling : implications in ADPKD cell proliferation .
16730065	0	CREB	0,4	RFX5	36,40	CREB	RFX5	1385	5993	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	CREB and phospho-CREB interact with RFX5 and CIITA to regulate MHC class II genes .
25541153	0	CREB	27,31	Replication_factor_C3	0,21	CREB	Replication factor C3	1385	5983	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Replication_factor_C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA .
21836635	0	CREB	0,4	SIRT1	36,41	CREB	SIRT1	1385	23411	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nummod|END_ENTITY	CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability .
19113914	0	CREB	20,24	SOX9	0,4	CREB	SOX9	1385	6662	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation .
23292070	0	CREB	40,44	Sirt1	0,5	CREB	Sirt1	81646(Tax:10116)	309757(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Sirt1 inhibits the transcription factor CREB to regulate pituitary growth_hormone synthesis .
1352292	0	CREB	89,93	Somatostatin	0,12	CREB	Somatostatin	1385	6750	Gene	Gene	consisting|nmod|START_ENTITY complex|acl|consisting activated|nmod|complex activated|nsubj|gene gene|compound|END_ENTITY	Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB , Isl-1-like , and alpha-CBF-like transcription factors .
11290288	0	CREB	84,88	Sonic_hedgehog	22,36	CREB	Sonic hedgehog	1385	6469	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Vitronectin regulates Sonic_hedgehog activity during cerebellum development through CREB phosphorylation .
22627767	0	CREB	21,25	Sox4	0,4	CREB	Sox4	12912(Tax:10090)	20677(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Sox4 cooperates with CREB in myeloid transformation .
20303596	0	CREB	8,12	TNFalpha	30,38	CREB	TNFalpha	1385	7124	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264 .7 macrophages .
26755589	0	CREB	41,45	TRAF3	8,13	CREB	TRAF3	1385	7187	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Nuclear TRAF3 is a negative regulator of CREB in B cells .
15964553	0	CREB	92,96	TSSK5	0,5	CREB	TSSK5	1385	283629	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	TSSK5 , a novel member of the testis-specific serine/threonine kinase family , phosphorylates CREB at Ser-133 , and stimulates the CRE/CREB responsive pathway .
23239345	0	CREB	31,35	Thioredoxin-1	0,13	CREB	Thioredoxin-1	81646(Tax:10116)	116484(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	Thioredoxin-1 was required for CREB activity by methamphetamine in rat pheochromocytoma cells .
22932066	0	CREB	110,114	basic_fibroblast_growth_factor	51,81	CREB	basic fibroblast growth factor	81646(Tax:10116)	54250(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Different signal transduction pathways elicited by basic_fibroblast_growth_factor and interleukin_1b regulate CREB phosphorylation in Sertoli cells .
8798441	0	CREB	0,4	bcl-2	66,71	CREB	bcl-2	1385	596	Gene	Gene	proteins|compound|START_ENTITY function|nsubj|proteins function|advcl|lymphomas lymphomas|nsubj|regulators regulators|nmod|allele allele|amod|END_ENTITY	CREB proteins function as positive regulators of the translocated bcl-2 allele in t -LRB- 14 ; 18 -RRB- _ lymphomas .
8816467	0	CREB	48,52	bcl-2	13,18	CREB	bcl-2	1385	596	Gene	Gene	proteins|compound|START_ENTITY phosphorylated|dobj|proteins phosphorylated|nsubj|Induction Induction|nmod|expression expression|amod|END_ENTITY	Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis .
19046370	0	CREB	79,83	brain-derived_neurotrophic_factor	99,132	CREB	brain-derived neurotrophic factor	1385	627	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain-derived_neurotrophic_factor promoter .
15531295	0	CREB	76,80	c-Fos	69,74	CREB	c-Fos	12912(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Piperine is a potent inhibitor of nuclear factor-kappaB -LRB- NF-kappaB -RRB- , c-Fos , CREB , ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells .
26493679	0	CREB	0,4	c-Fos	145,150	CREB	c-Fos	1385	2353	Gene	Gene	connect|nsubj|START_ENTITY connect|nmod|expression expression|amod|END_ENTITY	CREB , AP-1 , ternary complex factors and MAP kinases connect transient_receptor_potential_melastatin-3 -LRB- TRPM3 -RRB- channel stimulation with increased c-Fos expression .
9098578	0	CREB	0,4	c-Fos	141,146	CREB	c-Fos	1385	2353	Gene	Gene	phosphorylation|compound|START_ENTITY altered|nsubjpass|phosphorylation altered|nmod|cholecystokinin cholecystokinin|acl:relcl|induces induces|dobj|END_ENTITY	CREB phosphorylation in the nucleus of the solitary tract and parabrachial nucleus is not altered by peripheral cholecystokinin that induces c-Fos .
12196545	0	CREB	142,146	c-Myb	120,125	CREB	c-Myb	1385	4602	Gene	Gene	constitutive|appos|START_ENTITY constitutive|appos|END_ENTITY	Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding_protein by constitutive -LRB- c-Myb -RRB- and inducible -LRB- CREB -RRB- activators .
12137955	0	CREB	114,118	c-fos	37,42	CREB	c-fos	1385	2353	Gene	Gene	elements|appos|START_ENTITY mediated|nmod|elements mediated|nsubjpass|induction induction|nmod|promoter promoter|amod|END_ENTITY	Ultraviolet B -LRB- UVB -RRB- induction of the c-fos promoter is mediated by phospho-cAMP_response_element_binding_protein -LRB- CREB -RRB- binding to CRE and c-fos activator protein 1 site -LRB- FAP1 -RRB- cis elements .
12432566	0	CREB	8,12	c-fos	37,42	CREB	c-fos	1385	2353	Gene	Gene	factor|compound|START_ENTITY Role|nmod|factor Role|nmod|activation activation|amod|END_ENTITY	Role of CREB transcription factor in c-fos activation in natural killer cells .
20574536	0	CREB	55,59	c-fos	14,19	CREB	c-fos	12912(Tax:10090)	14281(Tax:10090)	Gene	Gene	responds|nmod|START_ENTITY promoter|acl:relcl|responds promoter|compound|END_ENTITY	A novel mouse c-fos intronic promoter that responds to CREB and AP-1 is developmentally regulated in vivo .
2157471	0	CREB	107,111	c-fos	43,48	CREB	c-fos	1385	2353	Gene	Gene	phosphorylation|nmod|START_ENTITY transcription|nmod|phosphorylation transcription|amod|END_ENTITY	Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB .
22079318	0	CREB	52,56	c-fos	79,84	CREB	c-fos	81646(Tax:10116)	314322(Tax:10116)	Gene	Gene	inhibitor|nmod|START_ENTITY A-CREB|appos|inhibitor A-CREB|nmod|expression expression|nmod|END_ENTITY	Effects of A-CREB , a dominant negative inhibitor of CREB , on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo .
8205620	0	CREB	120,124	c-fos	77,82	CREB	c-fos	1385	2353	Gene	Gene	phosphorylation|nmod|START_ENTITY transcription|nmod|phosphorylation transcription|amod|END_ENTITY	Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB .
8574661	0	CREB	92,96	c-fos	21,26	CREB	c-fos	81646(Tax:10116)	314322(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY expression|nmod|phosphorylation expression|amod|END_ENTITY	Nitric_oxide induces c-fos gene expression via cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- phosphorylation in rat retinal_pigment_epithelium .
9030636	0	CREB	40,44	c-fos	117,122	CREB	c-fos	81646(Tax:10116)	314322(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|dep|relationship relationship|nmod|induction induction|amod|END_ENTITY	Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia : relationship to c-fos induction .
9447994	0	CREB	33,37	c-fos	115,120	CREB	c-fos	81646(Tax:10116)	314322(Tax:10116)	Gene	Gene	inhibitor|nmod|START_ENTITY reveals|nsubj|inhibitor reveals|ccomp|mediator mediator|nmod|transcription transcription|nmod|END_ENTITY	A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos .
9770464	0	CREB	83,87	c-fos	117,122	CREB	c-fos	1385	2353	Gene	Gene	protein|compound|START_ENTITY protein|nmod|gene gene|amod|END_ENTITY	Rsk-2 activity is necessary for epidermal_growth_factor-induced phosphorylation of CREB protein and transcription of c-fos gene .
9850145	0	CREB	74,78	c-fos	11,16	CREB	c-fos	12912(Tax:10090)	14281(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY middle_cerebral_artery_occlusion|nmod|mice induction|nmod|middle_cerebral_artery_occlusion induction|amod|END_ENTITY	Attenuated c-fos mRNA induction after middle_cerebral_artery_occlusion in CREB knockout mice does not modulate focal ischemic_injury .
11988078	0	CREB	85,89	cAMP-response-element-binding_protein	46,83	CREB	cAMP-response-element-binding protein	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	A novel pathway for adrenergic stimulation of cAMP-response-element-binding_protein -LRB- CREB -RRB- phosphorylation : mediation via alpha1-adrenoceptors and protein kinase C activation .
12368293	0	CREB	133,137	cAMP-response_element-binding_protein	94,131	CREB	cAMP-response element-binding protein	1385	1385	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Nitric_oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response_element-binding_protein -LRB- CREB -RRB- activation .
12743114	0	CREB	121,125	cAMP-response_element-binding_protein	82,119	CREB	cAMP-response element-binding protein	1385	1385	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Tissue_transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response_element-binding_protein -LRB- CREB -RRB- activation .
18694792	0	CREB	97,101	cAMP-response_element-binding_protein	103,140	CREB	cAMP-response element-binding protein	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|appos|END_ENTITY	NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein_kinase_A and CREB -LRB- cAMP-response_element-binding_protein -RRB- pathway .
10406459	0	CREB	133,137	cAMP-responsive_element-binding_protein	139,178	CREB	cAMP-responsive element-binding protein	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	A dominant role for the Raf-MEK pathway in forskolin , 12-O-tetradecanoyl-phorbol_acetate , and platelet-derived growth factor-induced CREB -LRB- cAMP-responsive_element-binding_protein -RRB- activation , uncoupled from serine 133 phosphorylation in NIH 3T3 cells .
1331087	0	CREB	113,117	cAMP_regulatory_element_binding	72,103	CREB	cAMP regulatory element binding	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Beta-adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP_regulatory_element_binding protein -LRB- CREB -RRB- - dependent and tissue-specific CREB-independent mechanisms in corticotrope cells .
10804193	0	CREB	110,114	cAMP_response_element-binding_protein	71,108	CREB	cAMP response element-binding protein	1385	1385	Gene	Gene	dephosphorylation|appos|START_ENTITY dephosphorylation|nmod|END_ENTITY	Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP_response_element-binding_protein -LRB- CREB -RRB- in hippocampal neurons .
12540838	0	CREB	91,95	cAMP_response_element-binding_protein	52,89	CREB	cAMP response element-binding protein	1385	1385	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Persistent ERK phosphorylation negatively regulates cAMP_response_element-binding_protein -LRB- CREB -RRB- activity via recruitment of CREB-binding_protein to pp90RSK .
17127423	0	CREB	72,76	cAMP_response_element-binding_protein	33,70	CREB	cAMP response element-binding protein	1385	1385	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Multisite phosphorylation of the cAMP_response_element-binding_protein -LRB- CREB -RRB- by a diversity of protein kinases .
23990467	0	CREB	168,172	cAMP_response_element-binding_protein	129,166	CREB	cAMP response element-binding protein	1385	1385	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species -LRB- ROS -RRB- levels and cAMP_response_element-binding_protein -LRB- CREB -RRB- activation .
12435435	0	CREB	50,54	cAMP_response_element_binding	19,48	CREB	cAMP response element binding	1385	1385	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Phosphorylation of cAMP_response_element_binding -LRB- CREB -RRB- protein during hypoxia in cerebral cortex of newborn piglets and the effect of nitric_oxide_synthase inhibition .
16598418	0	CREB	58,62	cAMP_response_element_binding_protein	19,56	CREB	cAMP response element binding protein	1385	1385	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of cAMP_response_element_binding_protein -LRB- CREB -RRB- as a marker of hypoxia in pituitary_adenoma .
9030696	0	CREB	53,57	cAMP_response_element_binding_protein	14,51	CREB	cAMP response element binding protein	1385	1385	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cAMP_response_element_binding_protein -LRB- CREB -RRB- binding in the mammalian clock pacemaker by light but not a circadian clock .
10728443	0	CREB	56,60	cAMP_responsive_element_binding_protein	15,54	CREB	cAMP responsive element binding protein	1385	1385	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of cAMP_responsive_element_binding_protein -LRB- CREB -RRB- in the synovial cell hyperfunction in patients with rheumatoid_arthritis .
1387109	0	CREB	10,14	cAMP_responsive_element_binding_protein	16,55	CREB	cAMP responsive element binding protein	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse CREB -LRB- cAMP_responsive_element_binding_protein -RRB- gene : structure , promoter analysis , and chromosomal localization .
25843777	0	CREB	0,4	carbonic_anhydrase_IX	36,57	CREB	carbonic anhydrase IX	1385	768	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	CREB is a key negative regulator of carbonic_anhydrase_IX -LRB- CA9 -RRB- in gastric_cancer .
25843777	0	CREB	0,4	carbonic_anhydrase_IX	36,57	CREB	carbonic anhydrase IX	1385	768	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	CREB is a key negative regulator of carbonic_anhydrase_IX -LRB- CA9 -RRB- in gastric_cancer .
15030385	0	CREB	107,111	cholecystokinin	46,61	CREB	cholecystokinin	1385	885	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	KCl and forskolin synergistically up-regulate cholecystokinin gene expression via coordinate activation of CREB and the co-activator CBP .
23768074	0	CREB	33,37	corticotropin-releasing_hormone	49,80	CREB	corticotropin-releasing hormone	1385	1392	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Differential contribution of CBP : CREB binding to corticotropin-releasing_hormone expression in the infant and adult hypothalamus .
22616931	0	CREB	64,68	cyclic_AMP-response_element-binding_protein	19,62	CREB	cyclic AMP-response element-binding protein	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of cyclic_AMP-response_element-binding_protein -LRB- CREB -RRB- is influenced by melatonin treatment in pancreatic rat insulinoma b-cells -LRB- INS-1 -RRB- .
7922574	0	CREB	70,74	cyclic_AMP-response_element_binding_protein	25,68	CREB	cyclic AMP-response element binding protein	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A developmental study of cyclic_AMP-response_element_binding_protein -LRB- CREB -RRB- by in situ hybridization histochemistry and immunocytochemistry in the rat neocortex .
9037515	0	CREB	63,67	cyclic_AMP-responsive_element_binding_protein	16,61	CREB	cyclic AMP-responsive element binding protein	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the cyclic_AMP-responsive_element_binding_protein -LRB- CREB -RRB- in hypoxic-ischemic_brain_damage and repair .
18036509	0	CREB	59,63	cyclic_AMP_response-element_binding-protein	14,57	CREB	cyclic AMP response-element binding-protein	1385	1385	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cyclic_AMP_response-element_binding-protein -LRB- CREB -RRB- by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells .
19050160	0	CREB	95,99	cyclic_AMP_response_element-binding	58,93	CREB	cyclic AMP response element-binding	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Spatial memory in the Morris water maze and activation of cyclic_AMP_response_element-binding -LRB- CREB -RRB- protein within the mouse hippocampus .
22269225	0	CREB	103,107	cyclic_AMP_response_element_binding_protein	58,101	CREB	cyclic AMP response element binding protein	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Dysregulated phosphorylation and nuclear translocation of cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- in rat liver after chronic ethanol binge .
8574661	0	CREB	92,96	cyclic_AMP_response_element_binding_protein	47,90	CREB	cyclic AMP response element binding protein	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Nitric_oxide induces c-fos gene expression via cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- phosphorylation in rat retinal_pigment_epithelium .
7760825	0	CREB	101,105	cyclin_A	25,33	CREB	cyclin A	1385	890	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Cell cycle regulation of cyclin_A gene expression by the cyclic_AMP-responsive transcription factors CREB and CREM .
23838680	0	CREB	14,18	cyclin_D1	61,70	CREB	cyclin D1	1385	595	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CREB in primary pterygium and correlation with cyclin_D1 , ki-67 , MMP7 , p53 , p63 , Survivin and Vimentin .
10777619	0	CREB	41,45	cytochrome_c	125,137	CREB	cytochrome c	1385	54205	Gene	Gene	activation|nmod|START_ENTITY leads|nsubj|activation leads|nmod|induction induction|nmod|END_ENTITY	Sequential serum-dependent activation of CREB and NRF-1 leads to enhanced mitochondrial respiration through the induction of cytochrome_c .
12456801	0	CREB	159,163	early_growth_response_protein_1	15,46	CREB	early growth response protein 1	1385	1958	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of early_growth_response_protein_1 -LRB- Egr-1 -RRB- , specificity_protein_1 -LRB- Sp1 -RRB- , and cyclic_adenosine_3 ' 5 ' - monophosphate response element binding protein -LRB- CREB -RRB- at a proximal response element is critical for gastrin-dependent activation of the chromogranin_A promoter .
23341039	0	CREB	0,4	glucose_transporter_3	42,63	CREB	glucose transporter 3	1385	6515	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	CREB regulates the expression of neuronal glucose_transporter_3 : a possible mechanism related to impaired brain glucose uptake in Alzheimer 's _ disease .
24045154	0	CREB	25,29	interleukin-17A	39,54	CREB	interleukin-17A	12912(Tax:10090)	16171(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis .
16854377	0	CREB	89,93	macrophage_migration_inhibitory_factor	19,57	CREB	macrophage migration inhibitory factor	1385	4282	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|regulation regulation|nmod|END_ENTITY	Dual regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in hypoxia by CREB and HIF-1 .
22210353	0	CREB	174,178	matrix_metalloproteinase-2	125,151	CREB	matrix metalloproteinase-2	1385	4313	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Dioscorea nipponica Makino inhibits migration and invasion of human oral_cancer HSC-3 cells by transcriptional inhibition of matrix_metalloproteinase-2 through modulation of CREB and AP-1 activity .
17646388	0	CREB	39,43	mucin	14,19	CREB	mucin	1385	100508689	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of mucin gene expression by CREB via a nonclassical retinoic_acid signaling pathway .
10737596	0	CREB	17,21	neurotrophin-3	92,106	CREB	neurotrophin-3	1385	4908	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of CREB in the stimulation of oligodendrocyte precursor cell proliferation by neurotrophin-3 .
12370297	0	CREB	66,70	nocturnin	24,33	CREB	nocturnin	379764(Tax:8355)	378568(Tax:8355)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|END_ENTITY	Circadian regulation of nocturnin transcription by phosphorylated CREB in Xenopus retinal photoreceptor cells .
22710715	0	CREB	68,72	p21-Activated_kinase_4	0,22	CREB	p21-Activated kinase 4	1385	10298	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	p21-Activated_kinase_4 promotes prostate_cancer progression through CREB .
24366569	0	CREB	130,134	p21-activated_kinase_4	12,34	CREB	p21-activated kinase 4	1385	10298	Gene	Gene	regulation|nmod|START_ENTITY cells|nmod|regulation migration|nmod|cells suppresses|dobj|migration suppresses|nsubj|PF-3758309 PF-3758309|appos|inhibitor inhibitor|amod|END_ENTITY	PF-3758309 , p21-activated_kinase_4 inhibitor , suppresses migration and invasion of A549 human lung_cancer cells via regulation of CREB , NF-kB , and b-catenin signalings .
23639288	0	CREB	81,85	p38b	57,61	CREB	p38b	1385	5600	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	p27 suppresses cyclooxygenase-2 expression by inhibiting p38b and p38 - mediated CREB phosphorylation upon arsenite exposure .
2573431	0	CREB	76,80	somatostatin	22,34	CREB	somatostatin	81646(Tax:10116)	24797(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Cyclic_AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 .
7799950	0	CREB	54,58	somatostatin	109,121	CREB	somatostatin	81646(Tax:10116)	24797(Tax:10116)	Gene	Gene	START_ENTITY|dobj|repressor repressor|nmod|transcription transcription|nmod|gene gene|compound|END_ENTITY	Impaired cyclic_AMP-dependent phosphorylation renders CREB a repressor of C/EBP-induced transcription of the somatostatin gene in an insulinoma cell line .
17031850	0	CREB-1	151,157	ATF-2	145,150	CREB-1	ATF-2	1385	1386	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Differential regulation of cyclooxygenase-2 and inducible nitric_oxide synthase by 4-hydroxynonenal in human osteoarthritic chondrocytes through ATF-2 / CREB-1 transactivation and concomitant inhibition of NF-kappaB signaling cascade .
27094031	0	CREB-1	83,89	ATF-2	77,82	CREB-1	ATF-2	1385	1386	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	CD99 isoforms regulate CD1a expression in human monocyte-derived DCs through ATF-2 / CREB-1 phosphorylation .
10207073	0	CREB-Binding_protein	0,20	GATA-1	67,73	CREB-Binding protein	GATA-1	1387	2623	Gene	Gene	acetylates|nsubj|START_ENTITY acetylates|dobj|END_ENTITY	CREB-Binding_protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites .
26338335	0	CREB-Regulated_Transcription_Coactivator_3	65,107	Crf	34,37	CREB-Regulated Transcription Coactivator 3	Crf	64784	1392	Gene	Gene	Transcription|nmod|START_ENTITY Transcription|compound|END_ENTITY	Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated_Transcription_Coactivator_3 .
10400751	0	CREB-binding_protein	102,122	BZLF1	23,28	CREB-binding protein	BZLF1	1387	3783744(Tax:10376)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The Epstein-Barr_virus BZLF1 protein interacts physically and functionally with the histone acetylase CREB-binding_protein .
10760264	0	CREB-binding_protein	29,49	CBP	51,54	CREB-binding protein	CBP	12914(Tax:10090)	12914(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A stimulus-specific role for CREB-binding_protein -LRB- CBP -RRB- in T cell receptor-activated tumor_necrosis_factor_alpha gene expression .
15950780	0	CREB-binding_protein	26,46	CBP	48,51	CREB-binding protein	CBP	54244(Tax:10116)	54244(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Interleukin-1beta induces CREB-binding_protein -LRB- CBP -RRB- mRNA in brain and the sequencing of rat CBP .
24338025	0	CREB-binding_protein	54,74	CBP	76,79	CREB-binding protein	CBP	1387	1387	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	NF-kB and enhancer-binding CREB protein scaffolded by CREB-binding_protein -LRB- CBP -RRB- / p300 proteins regulate CD59 protein expression to protect cells from complement attack .
14594809	0	CREB-binding_protein	38,58	CITED2	89,95	CREB-binding protein	CITED2	1387	10370	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Interaction of the TAZ1 domain of the CREB-binding_protein with the activation domain of CITED2 : regulation by competition between intrinsically unstructured ligands for non-identical binding sites .
15051727	0	CREB-binding_protein	22,42	CITED2	68,74	CREB-binding protein	CITED2	12914(Tax:10090)	17684(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of the CREB-binding_protein / p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator .
10669739	0	CREB-binding_protein	40,60	Cubitus_interruptus	0,19	CREB-binding protein	Cubitus interruptus	43856(Tax:7227)	43767(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Cubitus_interruptus requires Drosophila CREB-binding_protein to activate wingless expression in the Drosophila embryo .
10982847	0	CREB-binding_protein	84,104	ER81	44,48	CREB-binding protein	ER81	1387	2115	Gene	Gene	Phosphorylation|amod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding_protein and p300 .
9482838	0	CREB-binding_protein	0,20	GATA-1	58,64	CREB-binding protein	GATA-1	12914(Tax:10090)	14460(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	CREB-binding_protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation .
15950780	0	CREB-binding_protein	26,46	Interleukin-1beta	0,17	CREB-binding protein	Interleukin-1beta	54244(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY induces|dobj|mRNA induces|nsubj|END_ENTITY	Interleukin-1beta induces CREB-binding_protein -LRB- CBP -RRB- mRNA in brain and the sequencing of rat CBP .
23223795	0	CREB-binding_protein	0,20	Ku70	31,35	CREB-binding protein	Ku70	1387	2547	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|acetylation acetylation|amod|END_ENTITY	CREB-binding_protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma .
11154691	0	CREB-binding_protein	36,56	NF-E2	15,20	CREB-binding protein	NF-E2	1387	4778	Gene	Gene	binding|nmod|START_ENTITY DNA|amod|binding DNA|compound|END_ENTITY	Stimulation of NF-E2 DNA binding by CREB-binding_protein -LRB- CBP -RRB- - mediated acetylation .
12403783	0	CREB-binding_protein	32,52	STAT1	69,74	CREB-binding protein	STAT1	1387	6772	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The transcriptional coactivator CREB-binding_protein cooperates with STAT1 and NF-kappa_B for synergistic transcriptional activation of the CXC_ligand_9 / monokine_induced_by_interferon-gamma gene .
22807441	0	CREB-binding_protein	33,53	Sirtuin_1	54,63	CREB-binding protein	Sirtuin 1	1387	23411	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	The acetylase/deacetylase couple CREB-binding_protein / Sirtuin_1 controls hypoxia-inducible factor 2 signaling .
14594809	0	CREB-binding_protein	38,58	TAZ1	19,23	CREB-binding protein	TAZ1	1387	6901	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Interaction of the TAZ1 domain of the CREB-binding_protein with the activation domain of CITED2 : regulation by competition between intrinsically unstructured ligands for non-identical binding sites .
11973335	0	CREB-binding_protein	31,51	beta-catenin	15,27	CREB-binding protein	beta-catenin	1387	1499	Gene	Gene	Acetylation|nmod|START_ENTITY Acetylation|nmod|END_ENTITY	Acetylation of beta-catenin by CREB-binding_protein -LRB- CBP -RRB- .
15929978	0	CREB-binding_protein	11,31	fibroblast_growth_factor_receptor-1	53,88	CREB-binding protein	fibroblast growth factor receptor-1	1387	2260	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Control of CREB-binding_protein signaling by nuclear fibroblast_growth_factor_receptor-1 : a novel mechanism of gene regulation .
26247811	0	CREB-binding_protein	22,42	homeodomain-interacting_protein_kinase_2	46,86	CREB-binding protein	homeodomain-interacting protein kinase 2	1387	28996	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Complex regulation of CREB-binding_protein by homeodomain-interacting_protein_kinase_2 .
10893273	0	CREB-binding_protein	0,20	p300	27,31	CREB-binding protein	p300	1387	2033	Gene	Gene	/|nsubj|START_ENTITY /|dobj|colocalize colocalize|amod|END_ENTITY	CREB-binding_protein -LRB- CBP -RRB- / p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus .
10944526	0	CREB-binding_protein	0,20	p300	21,25	CREB-binding protein	p300	1387	2033	Gene	Gene	START_ENTITY|parataxis|activates activates|nsubj|END_ENTITY	CREB-binding_protein / p300 activates MyoD by acetylation .
11509556	0	CREB-binding_protein	41,61	p300	62,66	CREB-binding protein	p300	1387	2033	Gene	Gene	Acetylation|nmod|START_ENTITY Acetylation|parataxis|required required|nsubjpass|END_ENTITY	Acetylation by histone acetyltransferase CREB-binding_protein / p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene .
11940575	0	CREB-binding_protein	22,42	p300	43,47	CREB-binding protein	p300	1387	2033	Gene	Gene	involvement|nmod|START_ENTITY involvement|dep|END_ENTITY	Direct involvement of CREB-binding_protein / p300 in sequence-specific DNA binding of virus-activated interferon_regulatory_factor-3 holocomplex .
11943779	0	CREB-binding_protein	0,20	p300	21,25	CREB-binding protein	p300	1387	2033	Gene	Gene	START_ENTITY|dep|co-activation co-activation|amod|END_ENTITY	CREB-binding_protein / p300 co-activation of crystallin gene expression .
15623506	0	CREB-binding_protein	64,84	p300	85,89	CREB-binding protein	p300	1387	2033	Gene	Gene	recruitment|compound|START_ENTITY recruitment|amod|END_ENTITY	Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding_protein / p300 recruitment .
15722556	0	CREB-binding_protein	30,50	p300	51,55	CREB-binding protein	p300	1387	2033	Gene	Gene	START_ENTITY|parataxis|chondrocyte chondrocyte|nsubj|increase increase|amod|END_ENTITY	Transcriptional Co-activators CREB-binding_protein / p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding _ protein .
16291753	0	CREB-binding_protein	127,147	p300	148,152	CREB-binding protein	p300	1387	2033	Gene	Gene	coactivator|compound|START_ENTITY coactivator|amod|END_ENTITY	A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding_protein / p300 coactivator .
17372613	0	CREB-binding_protein	9,29	p300	36,40	CREB-binding protein	p300	1387	2033	Gene	Gene	Roles|nmod|START_ENTITY Roles|dep|END_ENTITY	Roles of CREB-binding_protein -LRB- CBP -RRB- / p300 in respiratory epithelium tumorigenesis .
19880525	0	CREB-binding_protein	142,162	p300	163,167	CREB-binding protein	p300	1387	2033	Gene	Gene	/|amod|START_ENTITY domains|nmod|/ interaction|nmod|domains hypoxia-inducible_factor-1_alpha|nmod|interaction END_ENTITY|amod|hypoxia-inducible_factor-1_alpha	Complex regulation of the transactivation function of hypoxia-inducible_factor-1_alpha by direct interaction with two distinct domains of the CREB-binding_protein / p300 .
24338025	0	CREB-binding_protein	54,74	p300	81,85	CREB-binding protein	p300	1387	2033	Gene	Gene	proteins|amod|START_ENTITY proteins|nummod|END_ENTITY	NF-kB and enhancer-binding CREB protein scaffolded by CREB-binding_protein -LRB- CBP -RRB- / p300 proteins regulate CD59 protein expression to protect cells from complement attack .
9096323	0	CREB-binding_protein	0,20	p300	21,25	CREB-binding protein	p300	1387	2033	Gene	Gene	START_ENTITY|parataxis|coactivators coactivators|nsubj|END_ENTITY	CREB-binding_protein / p300 are transcriptional coactivators of p65 .
16738488	0	CREB-binding_protein	0,20	presenilin_1	35,47	CREB-binding protein	presenilin 1	12914(Tax:10090)	19164(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	CREB-binding_protein activation by presenilin_1 but not by its M146L mutant .
9388250	0	CREB-binding_protein	4,24	serum_response_factor	51,72	CREB-binding protein	serum response factor	1387	6722	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The CREB-binding_protein -LRB- CBP -RRB- cooperates with the serum_response_factor for transactivation of the c-fos serum response element .
10760264	0	CREB-binding_protein	29,49	tumor_necrosis_factor_alpha	85,112	CREB-binding protein	tumor necrosis factor alpha	12914(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	A stimulus-specific role for CREB-binding_protein -LRB- CBP -RRB- in T cell receptor-activated tumor_necrosis_factor_alpha gene expression .
18246306	0	CREB-binding_proteins	0,21	GATA-2	64,70	CREB-binding proteins	GATA-2	1387	2624	Gene	Gene	START_ENTITY|nmod|coactivator coactivator|nmod|END_ENTITY	CREB-binding_proteins -LRB- CBP -RRB- as a transcriptional coactivator of GATA-2 .
12111373	0	CREB4	101,106	CREB	88,92	CREB4	CREB	148327	1385	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of a novel human cAMP response element-binding -LRB- CREB -RRB- gene -LRB- CREB4 -RRB- .
14974086	0	CREBBP	17,23	CBP	12,15	CREBBP	CBP	1387	1387	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of CBP -LRB- CREBBP -RRB- gene deletions in Rubinstein-Taybi_syndrome patients using real-time quantitative PCR .
21752352	0	CREBBP	44,50	CREB_binding_protein	22,42	CREBBP	CREB binding protein	1387	1387	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism of the CREB_binding_protein -LRB- CREBBP -RRB- gene is a risk factor for addiction .
7606928	0	CREBBP	22,28	CREB_binding_protein	30,50	CREBBP	CREB binding protein	1387	1387	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of human CREBBP -LRB- CREB_binding_protein -RRB- to 16p13 .3 by fluorescence in situ hybridization .
21994947	0	CREBH	191,196	SMILE	99,104	CREBH	SMILE	84699	58487	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE -LRB- small_heterodimer_partner-interacting_leucine_zipper_protein -RRB- - mediated inhibition of CREBH -LRB- cAMP_responsive_element-binding_protein_H -RRB- .
24424044	0	CREBH	36,41	peroxisome_proliferator-activated_receptor_a	57,101	CREBH	peroxisome proliferator-activated receptor a	208677(Tax:10090)	19013(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Liver-enriched transcription factor CREBH interacts with peroxisome_proliferator-activated_receptor_a to regulate metabolic hormone FGF21 .
22983008	0	CREBZF	25,31	p53	65,68	CREBZF	p53	58487	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The transcription factor CREBZF is a novel positive regulator of p53 .
24200963	0	CREBZF	65,71	p53	163,166	CREBZF	p53	58487	7157	Gene	Gene	Effects|appos|START_ENTITY exerted|nsubjpass|Effects exerted|nmod|END_ENTITY	Effects of cyclic_AMP response element binding protein-Zhangfei -LRB- CREBZF -RRB- on the unfolded protein response and cell growth are exerted through the tumor suppressor p53 .
16969114	0	CREB_binding_protein	26,46	CBP	48,51	CREB binding protein	CBP	1387	1387	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Functional interaction of CREB_binding_protein -LRB- CBP -RRB- with nuclear transport proteins and modulation by HDAC inhibitors .
22508984	0	CREB_binding_protein	0,20	CBP	22,25	CREB binding protein	CBP	12914(Tax:10090)	12914(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	CREB_binding_protein -LRB- CBP -RRB- activation is required for luteinizing_hormone_beta expression and normal fertility in mice .
10848610	0	CREB_binding_protein	19,39	CREB	72,76	CREB binding protein	CREB	1387	1385	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	p53 recruitment of CREB_binding_protein mediated through phosphorylated CREB : a novel pathway of tumor suppressor regulation .
21752352	0	CREB_binding_protein	22,42	CREBBP	44,50	CREB binding protein	CREBBP	1387	1387	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism of the CREB_binding_protein -LRB- CREBBP -RRB- gene is a risk factor for addiction .
7606928	0	CREB_binding_protein	30,50	CREBBP	22,28	CREB binding protein	CREBBP	1387	1387	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of human CREBBP -LRB- CREB_binding_protein -RRB- to 16p13 .3 by fluorescence in situ hybridization .
15488321	0	CREB_binding_protein	47,67	calcium-responsive_transactivator	4,37	CREB binding protein	calcium-responsive transactivator	54244(Tax:10116)	192352(Tax:10116)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The calcium-responsive_transactivator recruits CREB_binding_protein to nuclear bodies .
10473588	0	CREB_binding_protein	36,56	p53	11,14	CREB binding protein	p53	1387	7157	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of p53 to the KIX domain of CREB_binding_protein .
10848610	0	CREB_binding_protein	19,39	p53	0,3	CREB binding protein	p53	1387	7157	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	p53 recruitment of CREB_binding_protein mediated through phosphorylated CREB : a novel pathway of tumor suppressor regulation .
21263217	0	CREG1	0,5	INK4a	19,24	CREG1	INK4a	8804	1029	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	CREG1 enhances p16 -LRB- INK4a -RRB- - induced cellular senescence .
18775413	0	CREM	0,4	CYP51	43,48	CREM	CYP51	12916(Tax:10090)	13121(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	CREM modulates the circadian expression of CYP51 , HMGCR and cholesterogenesis in the liver .
15725648	0	CREM	86,90	cAMP-responsive_element_modulator	51,84	CREM	cAMP-responsive element modulator	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	The administration of retinoic_acid down-regulates cAMP-responsive_element_modulator -LRB- CREM -RRB- mRNA in vitamin_A-deficient testes .
17889470	0	CREM	85,89	cAMP-responsive_element_modulator	50,83	CREM	cAMP-responsive element modulator	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of Rubus coreanus on sperm parameters and cAMP-responsive_element_modulator -LRB- CREM -RRB- expression in rat testes .
18374528	0	CREM	74,78	cAMP-responsive_element_modulator	39,72	CREM	cAMP-responsive element modulator	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of Psoralea corylifolia on the cAMP-responsive_element_modulator -LRB- CREM -RRB- expression and spermatogenesis in rats .
22025620	0	CREM	35,39	cAMP-responsive_element_modulator	0,33	CREM	cAMP-responsive element modulator	1390	1390	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	cAMP-responsive_element_modulator -LRB- CREM -RRB- a protein induces interleukin_17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic_lupus_erythematosus .
15804863	0	CREM	68,72	cAMP_response_element_modulator	35,66	CREM	cAMP response element modulator	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased testicular expression of cAMP_response_element_modulator -LRB- CREM -RRB- in rat with varicocele .
22056015	0	CREM	68,72	cyclic-AMP_responsive_element_modulator	27,66	CREM	cyclic-AMP responsive element modulator	1390	1390	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Differential expression of cyclic-AMP_responsive_element_modulator -LRB- CREM -RRB- mRNA isoforms during testicular development of boars .
11589148	0	CRF	38,41	ACTH	108,112	CRF	ACTH	1392	5443	Gene	Gene	expression|nmod|START_ENTITY expression|dep|implications implications|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Hypothalamic and limbic expression of CRF and vasopressin during lactation : implications for the control of ACTH secretion and stress hyporesponsiveness .
2830315	1	CRF	125,128	ACTH	197,201	CRF	ACTH	1392	5443	Gene	Gene	corticotropin-releasing_factor|appos|START_ENTITY bioassay|nmod|corticotropin-releasing_factor provides|nmod|bioassay provides|dobj|evidence evidence|nmod|mediation mediation|nmod|rhythm rhythm|nmod|END_ENTITY	In vivo bioassay of corticotropin-releasing_factor -LRB- CRF -RRB- which provides evidence for CRF mediation of the diurnal rhythm of ACTH .
2830315	1	CRF	158,161	ACTH	197,201	CRF	ACTH	1392	5443	Gene	Gene	mediation|compound|START_ENTITY mediation|nmod|rhythm rhythm|nmod|END_ENTITY	In vivo bioassay of corticotropin-releasing_factor -LRB- CRF -RRB- which provides evidence for CRF mediation of the diurnal rhythm of ACTH .
3001563	0	CRF	75,78	ACTH	81,85	CRF	ACTH	1392	5443	Gene	Gene	corticotropin_releasing_factor|appos|START_ENTITY application|nmod|corticotropin_releasing_factor application|dep|END_ENTITY	Intravenous application of ovine and human corticotropin_releasing_factor -LRB- CRF -RRB- : ACTH , cortisol and CRF levels .
3008569	0	CRF	24,27	ACTH	45,49	CRF	ACTH	1392	5443	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	By 95 days of gestation CRF increases plasma ACTH and cortisol in ovine fetuses .
3019060	0	CRF	0,3	ACTH	23,27	CRF	ACTH	1392	5443	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	CRF : its regulation of ACTH and pro-opiomelanocortin peptide release and its extra hypothalamic occurrence .
3019743	0	CRF	38,41	ACTH	70,74	CRF	ACTH	1392	5443	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolonged administration of CRF on plasma concentrations of ACTH in patients with Addison 's _ disease .
35343	1	CRF	175,178	ACTH	106,110	CRF	ACTH	1392	5443	Gene	Gene	corticotropin_releasing_factor|appos|START_ENTITY induced|nmod|corticotropin_releasing_factor induced|nsubj|Effect Effect|nmod|peptides peptides|nmod|release release|compound|END_ENTITY	Effect of neurogenic peptides and neurotransmitter substances on ACTH release induced by hypothalamic corticotropin_releasing_factor -LRB- CRF -RRB- .
6323156	0	CRF	59,62	ACTH	74,78	CRF	ACTH	1392	5443	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of synthetic ovine corticotropin-releasing_factor -LRB- CRF -RRB- on plasma ACTH and cortisol in 31 normal human males .
23376701	0	CRF	62,65	CGRP	22,26	CRF	CGRP	1392	796	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|nmod|END_ENTITY	Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors .
10414432	0	CRF	88,91	CRF	21,24	CRF	CRF	81648(Tax:10116)	1392	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Influence of peptide CRF receptor antagonists upon the behavioural effects of human/rat CRF .
20234885	0	CRF	58,61	CRF1	41,45	CRF	CRF1	1392	1394	Gene	Gene	receptor|nmod|START_ENTITY receptor|nummod|END_ENTITY	Emerging role of alternative splicing of CRF1 receptor in CRF signaling .
23376701	0	CRF	62,65	CRFR1	81,86	CRF	CRFR1	1392	1394	Gene	Gene	START_ENTITY|acl|acting acting|nmod|receptors receptors|compound|END_ENTITY	Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors .
16001267	0	CRF	32,35	Corticotropin-releasing_factor	0,30	CRF	Corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- expression in postnatal and adult rat sacral parasympathetic nucleus -LRB- SPN -RRB- .
21964377	0	CRF	32,35	Corticotropin-releasing_factor	0,30	CRF	Corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- receptor subtypes in mediating neuronal activation of brain areas involved in responses to intracerebroventricular CRF and stress in rats .
2546128	0	CRF	32,35	Corticotropin-releasing_factor	0,30	CRF	Corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- receptors in intermediate lobe of the pituitary : biochemical characterization and autoradiographic localization .
6383518	0	CRF	32,35	Corticotropin-releasing_factor	0,30	CRF	Corticotropin-releasing factor	1392	1392	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- immunoreactivity in the dorsolateral pontine tegmentum : further studies on the micturition reflex system .
2388526	0	CRF	46,49	NPY	38,41	CRF	NPY	81648(Tax:10116)	24604(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Inhibitory effects of neuropeptide_Y -LRB- NPY -RRB- on CRF and stress-induced cecal motor response in rats .
25751534	0	CRF	41,44	NPY	0,3	CRF	NPY	12917(Tax:10090)	109648(Tax:10090)	Gene	Gene	neurons|nsubj|START_ENTITY extended|ccomp|neurons extended|nsubj|inhibits inhibits|compound|END_ENTITY	NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking .
9427342	0	CRF	14,17	NPY	59,62	CRF	NPY	81648(Tax:10116)	24604(Tax:10116)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|dobj|effect effect|nmod|BIBP3226 BIBP3226|compound|END_ENTITY	Alpha-helical CRF -LRB- 9-41 -RRB- prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats .
2829145	0	CRF	0,3	POMC	27,31	CRF	POMC	12918(Tax:10090)	18976(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	CRF and cAMP regulation of POMC gene expression in corticotrophic_tumor cells .
8930307	0	CRF	24,27	c-fos	60,65	CRF	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Intracerebroventricular CRF inhibits cold restraint-induced c-fos expression in the dorsal motor nucleus of the vagus and gastric_erosions in rats .
10869378	0	CRF	40,43	corticotropin-releasing_factor	8,38	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Role of corticotropin-releasing_factor -LRB- CRF -RRB- receptors in the anorexic_syndrome induced by CRF .
10949116	0	CRF	40,43	corticotropin-releasing_factor	8,38	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of corticotropin-releasing_factor -LRB- CRF -RRB- in anxiety .
11290855	0	CRF	47,50	corticotropin-releasing_factor	15,45	CRF	corticotropin-releasing factor	12918(Tax:10090)	12921(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Mice that lack corticotropin-releasing_factor -LRB- CRF -RRB- receptors type 1 show a blunted ACTH response to acute alcohol despite up-regulated constitutive hypothalamic CRF gene expression .
12529934	0	CRF	60,63	corticotropin-releasing_factor	28,58	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Pharmacology and biology of corticotropin-releasing_factor -LRB- CRF -RRB- receptors .
12733706	0	CRF	46,49	corticotropin-releasing_factor	14,44	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of corticotropin-releasing_factor -LRB- CRF -RRB- type-1 receptor gene expression by CRF in the hypothalamus .
12733706	0	CRF	86,89	corticotropin-releasing_factor	14,44	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of corticotropin-releasing_factor -LRB- CRF -RRB- type-1 receptor gene expression by CRF in the hypothalamus .
1335535	0	CRF	60,63	corticotropin-releasing_factor	28,58	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of endogenous corticotropin-releasing_factor -LRB- CRF -RRB- in the mediation of the behavioral action of cocaine in rats .
1448118	0	CRF	64,67	corticotropin-releasing_factor	32,62	CRF	corticotropin-releasing factor	100337609(Tax:8355)	100337609(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the genomic corticotropin-releasing_factor -LRB- CRF -RRB- gene from Xenopus_laevis : two members of the CRF family exist in amphibians .
1494497	0	CRF	46,49	corticotropin-releasing_factor	14,44	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of corticotropin-releasing_factor -LRB- CRF -RRB- on autonomic and behavioral responses during shock-prod burying test in rats .
14971886	0	CRF	45,48	corticotropin-releasing_factor	13,43	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	New class of corticotropin-releasing_factor -LRB- CRF -RRB- antagonists : small peptides having high binding affinity for CRF receptor .
1533382	0	CRF	66,69	corticotropin-releasing_factor	34,64	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Dilatory and inotropic effects of corticotropin-releasing_factor -LRB- CRF -RRB- on the isolated heart .
16423333	0	CRF	56,59	corticotropin-releasing_factor	24,54	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Long-term expression of corticotropin-releasing_factor -LRB- CRF -RRB- in the paraventricular nucleus of the hypothalamus in response to an acute_colonic_inflammation .
1647252	0	CRF	57,60	corticotropin-releasing_factor	25,55	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Age-related decreases in corticotropin-releasing_factor -LRB- CRF -RRB- receptors in rat brain and anterior pituitary gland .
16492754	0	CRF	51,54	corticotropin-releasing_factor	19,49	CRF	corticotropin-releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Vital functions of corticotropin-releasing_factor -LRB- CRF -RRB- pathways in maintenance and regulation of energy homeostasis .
169120	0	CRF	79,82	corticotropin-releasing_factor	47,77	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Corticosterone-induced changes in hypothalamic corticotropin-releasing_factor -LRB- CRF -RRB- content after stress .
184025	0	CRF	57,60	corticotropin-releasing_factor	25,55	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Analysis of dynamics of corticotropin-releasing_factor -LRB- CRF -RRB- activity in the rat hypothalamus under stress -RSB- .
21192987	0	CRF	56,59	corticotropin-releasing_factor	24,54	CRF	corticotropin-releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of transgenic corticotropin-releasing_factor -LRB- CRF -RRB- over-expression on social recognition memory in mice .
23998289	0	CRF	80,83	corticotropin-releasing_factor	48,78	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	A possible solution for hair loss by inhibiting corticotropin-releasing_factor -LRB- CRF -RRB- receptor from traditional Chinese medicine .
2547206	0	CRF	43,46	corticotropin-releasing_factor	11,41	CRF	corticotropin-releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Functional corticotropin-releasing_factor -LRB- CRF -RRB- receptors in mouse spleen : evidence from adenylate cyclase studies .
2548115	0	CRF	80,83	corticotropin-releasing_factor	48,78	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Normal pattern of labeling of cerebral cortical corticotropin-releasing_factor -LRB- CRF -RRB- receptors in Alzheimer 's _ disease : evidence from chemical cross-linking studies .
2836182	0	CRF	43,46	corticotropin-releasing_factor	11,41	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_factor -LRB- CRF -RRB- on aldosterone and 18-hydroxycorticosterone in essential_hypertension and primary_aldosteronism .
2876885	0	CRF	56,59	corticotropin-releasing_factor	24,54	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Cytochemical studies of corticotropin-releasing_factor -LRB- CRF -RRB- receptors in anterior lobe corticotropes : binding , glucocorticoid regulation , and endocytosis of -LSB- biotinyl-Ser1 -RSB- CRF .
2982594	0	CRF	46,49	corticotropin-releasing_factor	14,44	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Regulation of corticotropin-releasing_factor -LRB- CRF -RRB- receptors in the rat pituitary gland : effects of adrenalectomy on CRF receptors and corticotroph responses .
3871498	0	CRF	66,69	corticotropin-releasing_factor	34,64	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Reduction|appos|START_ENTITY Reduction|nmod|END_ENTITY	Reduction in brain immunoreactive corticotropin-releasing_factor -LRB- CRF -RRB- in spontaneously hypertensive rats .
6099779	0	CRF	43,46	corticotropin-releasing_factor	11,41	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_factor -LRB- CRF -RRB- on aldosterone and 18-hydroxycorticosterone secretion .
6280987	0	CRF	92,95	corticotropin-releasing_factor	60,90	CRF	corticotropin-releasing factor	280755(Tax:9913)	280755(Tax:9913)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Differential effects of dithiothreitol and iodoacetamide on corticotropin-releasing_factor -LRB- CRF -RRB- activity of bovine hypothalamic CRFs and vasopressin .
6323156	0	CRF	59,62	corticotropin-releasing_factor	27,57	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of synthetic ovine corticotropin-releasing_factor -LRB- CRF -RRB- on plasma ACTH and cortisol in 31 normal human males .
6760710	0	CRF	67,70	corticotropin-releasing_factor	35,65	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of corticotropin-releasing_factor -LRB- CRF -RRB- in the rat brain .
7720627	0	CRF	72,75	corticotropin-releasing_factor	40,70	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Signaling properties of mouse and human corticotropin-releasing_factor -LRB- CRF -RRB- receptors : decreased coupling efficiency of human type II CRF receptor .
7796142	0	CRF	58,61	corticotropin-releasing_factor	26,56	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Prenatal stress increases corticotropin-releasing_factor -LRB- CRF -RRB- content and release in rat amygdala minces .
8170521	0	CRF	66,69	corticotropin-releasing_factor	34,64	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Depolarization-induced release of corticotropin-releasing_factor -LRB- CRF -RRB- in primary neuronal cultures of the amygdala .
8401569	0	CRF	55,58	corticotropin-releasing_factor	23,53	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of central corticotropin-releasing_factor -LRB- CRF -RRB- in suckling-induced inhibition of luteinizing hormone secretion in lactating rats .
8497182	0	CRF	80,83	corticotropin-releasing_factor	48,78	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Early , postnatal experience alters hypothalamic corticotropin-releasing_factor -LRB- CRF -RRB- mRNA , median eminence CRF content and stress-induced release in adult rats .
8636316	0	CRF	47,50	corticotropin-releasing_factor	15,45	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	High levels of corticotropin-releasing_factor -LRB- CRF -RRB- are inversely correlated with low levels of maternal CRF-binding_protein in pregnant women with pregnancy-induced hypertension .
8697187	0	CRF	47,50	corticotropin-releasing_factor	15,45	CRF	corticotropin-releasing factor	1392	1392	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of the corticotropin-releasing_factor -LRB- CRF -RRB- on rectal afferent nerves in humans .
9396068	0	CRF	46,49	corticotropin-releasing_factor	14,44	CRF	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of corticotropin-releasing_factor -LRB- CRF -RRB- in peritoneum and pericardium in the rat embryo by in situ hybridization histochemistry .
12397512	0	CRF	43,46	corticotropin_releasing_factor	11,41	CRF	corticotropin releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for corticotropin_releasing_factor -LRB- CRF -RRB- in ethanol consumption , sensitivity , and reward as revealed by CRF-deficient mice .
12845406	0	CRF	40,43	corticotropin_releasing_factor	8,38	CRF	corticotropin releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of corticotropin_releasing_factor -LRB- CRF -RRB- receptors 1 and 2 in CRF-potentiated acoustic startle in mice .
18397172	0	CRF	66,69	corticotropin_releasing_factor	34,64	CRF	corticotropin releasing factor	1392	1392	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Small molecule antagonists of the corticotropin_releasing_factor -LRB- CRF -RRB- receptor : recent medicinal chemistry developments .
18595780	0	CRF	56,59	corticotropin_releasing_factor	24,54	CRF	corticotropin releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Postnatal expression of corticotropin_releasing_factor -LRB- CRF -RRB- in rat urinary bladder .
21651923	0	CRF	43,46	corticotropin_releasing_factor	11,41	CRF	corticotropin releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin_releasing_factor -LRB- CRF -RRB- on sleep and body temperature following controllable footshock stress in mice .
26283899	0	CRF	43,46	corticotropin_releasing_factor	11,41	CRF	corticotropin releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin_releasing_factor -LRB- CRF -RRB- on sleep and temperature following predictable controllable and uncontrollable stress in mice .
26283899	0	CRF	43,46	corticotropin_releasing_factor	11,41	CRF	corticotropin releasing factor	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin_releasing_factor -LRB- CRF -RRB- on sleep and temperature following predictable controllable and uncontrollable stress in mice .
3498936	0	CRF	49,52	corticotropin_releasing_factor	17,47	CRF	corticotropin releasing factor	1392	1392	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of human corticotropin_releasing_factor -LRB- CRF -RRB- on gastric and pancreatic secretion in vivo and in vitro .
6194860	0	CRF	67,70	corticotropin_releasing_factor	35,65	CRF	corticotropin releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of corticotropin_releasing_factor -LRB- CRF -RRB- in the rat spinal cord .
9016842	0	CRF	42,45	corticotropin_releasing_factor	10,40	CRF	corticotropin releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of corticotropin_releasing_factor -LRB- CRF -RRB- injected into the median eminence on LH secretion in male rats .
9299209	0	CRF	74,77	corticotropin_releasing_factor	42,72	CRF	corticotropin releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Stress-induced sleep_deprivation modifies corticotropin_releasing_factor -LRB- CRF -RRB- levels and CRF binding in rat brain and pituitary .
7572270	0	CRF	116,119	interleukin-1	68,81	CRF	interleukin-1	81648(Tax:10116)	3552	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat .
2388526	0	CRF	46,49	neuropeptide_Y	22,36	CRF	neuropeptide Y	81648(Tax:10116)	24604(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of neuropeptide_Y -LRB- NPY -RRB- on CRF and stress-induced cecal motor response in rats .
9439821	0	CRF	91,94	neuropeptide_Y	26,40	CRF	neuropeptide Y	81648(Tax:10116)	24604(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes of immunoreactive neuropeptide_Y , somatostatin and corticotropin-releasing_factor -LRB- CRF -RRB- in the brain of a novel epileptic mutant rat , Ihara 's _ genetically_epileptic_rat -LRB- IGER -RRB- .
14724392	0	CRF-R1	68,74	corticotropin_releasing_factor	27,57	CRF-R1	corticotropin releasing factor	12921(Tax:10090)	12918(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Localization of the type 1 corticotropin_releasing_factor receptor -LRB- CRF-R1 -RRB- in the embryonic mouse cerebellum .
25960164	0	CRF-R1	66,72	corticotropin_releasing_factor	25,55	CRF-R1	corticotropin releasing factor	1394	1392	Gene	Gene	activation|appos|START_ENTITY activation|nmod|receptor receptor|compound|END_ENTITY	The activation of type 1 corticotropin_releasing_factor receptor -LRB- CRF-R1 -RRB- inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27 -LRB- Kip1 -RRB- protein up-regulation and c-Myc mRNA down-regulation .
16545343	0	CRF-binding_protein	93,112	Corticotropin-releasing_factor	0,30	CRF-binding protein	Corticotropin-releasing factor	29625(Tax:10116)	81648(Tax:10116)	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- , but not corticosterone , increases basolateral amygdala CRF-binding_protein .
20234885	0	CRF1	41,45	CRF	58,61	CRF1	CRF	1394	1392	Gene	Gene	receptor|nummod|START_ENTITY receptor|nmod|END_ENTITY	Emerging role of alternative splicing of CRF1 receptor in CRF signaling .
26456805	0	CRF1	246,250	corticotropin-releasing_factor_type-1	207,244	CRF1	corticotropin-releasing factor type-1	1394	1394	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Synthesis , binding affinity , radiolabeling , and microPET evaluation of 4 - -LRB- 2-substituted-4-substituted -RRB- -8 - -LRB- dialkylamino -RRB- -6 - methyl-1-substituted-3 ,4 - dihydropyrido -LSB- 2,3-b -RSB- pyrazin-2 -LRB- 1H -RRB- - ones as ligands for brain corticotropin-releasing_factor_type-1 -LRB- CRF1 -RRB- receptors .
15349973	0	CRF1	76,80	corticotropin-releasing_factor_type_1	37,74	CRF1	corticotropin-releasing factor type 1	574095(Tax:9544)	574095(Tax:9544)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Immunohistochemical visualization of corticotropin-releasing_factor_type_1 -LRB- CRF1 -RRB- receptors in monkey brain .
25665407	0	CRF1	109,113	corticotropin_releasing_factor	11,41	CRF1	corticotropin releasing factor	58959(Tax:10116)	81648(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY involvement|nmod|-RSB- Effect|dep|involvement Effect|nmod|END_ENTITY	-LSB- Effect of corticotropin_releasing_factor -LRB- CRF -RRB- on somatic_pain sensitivity in conscious rats : involvement of CRF1 and CRF2 receptors -RSB- .
9372207	0	CRF1	4,8	corticotropin_releasing_factor	53,83	CRF1	corticotropin releasing factor	58959(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY mediates|nsubj|receptor mediates|dobj|actions actions|nmod|END_ENTITY	The CRF1 receptor mediates the excitatory actions of corticotropin_releasing_factor -LRB- CRF -RRB- in the developing rat brain : in vivo evidence using a novel , selective , non-peptide CRF receptor antagonist .
9863624	0	CRF1	84,88	corticotropin_releasing_factor	43,73	CRF1	corticotropin releasing factor	1394	1392	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Structure and function of the ovine type 1 corticotropin_releasing_factor receptor -LRB- CRF1 -RRB- and a carboxyl-terminal variant .
15127940	0	CRF1	63,67	corticotropin_releasing_factor_1	29,61	CRF1	corticotropin releasing factor 1	58959(Tax:10116)	58959(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Conformational states of the corticotropin_releasing_factor_1 -LRB- CRF1 -RRB- receptor : detection , and pharmacological evaluation by peptide ligands .
22948128	0	CRF1	62,66	corticotropin_releasing_factor_receptor_type_1	14,60	CRF1	corticotropin releasing factor receptor type 1	1394	1394	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of corticotropin_releasing_factor_receptor_type_1 -LRB- CRF1 -RRB- in the human gastrointestinal tract and upregulation in the colonic_mucosa in patients with ulcerative_colitis .
7472399	0	CRF2	63,67	corticotropin-releasing_factor_receptor	22,61	CRF2	corticotropin-releasing factor receptor	64680(Tax:10116)	64680(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Localization of novel corticotropin-releasing_factor_receptor -LRB- CRF2 -RRB- mRNA expression to specific subcortical nuclei in rat brain : comparison with CRF1 receptor mRNA expression .
10234028	0	CRF2	93,97	corticotropin-releasing_factor_receptor_type_2	45,91	CRF2	corticotropin-releasing factor receptor type 2	64680(Tax:10116)	64680(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|expression expression|nmod|END_ENTITY	Differential regulation of the expression of corticotropin-releasing_factor_receptor_type_2 -LRB- CRF2 -RRB- in hypothalamus and amygdala of the immature rat by sensory input and food intake .
23376701	0	CRFR1	81,86	CRF	62,65	CRFR1	CRF	1394	1392	Gene	Gene	receptors|compound|START_ENTITY acting|nmod|receptors END_ENTITY|acl|acting	Anxiogenic effects of CGRP within the BNST may be mediated by CRF acting at BNST CRFR1 receptors .
26898829	0	CRFR1	17,22	PSD-95	0,6	CRFR1	PSD-95	1394	1742	Gene	Gene	localization|nummod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	PSD-95 regulates CRFR1 localization , trafficking and b-arrestin2 recruitment .
10806401	0	CRFR1	145,150	corticotropin-releasing_factor	52,82	CRFR1	corticotropin-releasing factor	1394	1392	Gene	Gene	type_1|appos|START_ENTITY antagonists|appos|type_1 antagonists|nmod|studies studies|amod|END_ENTITY	Novel high-affinity photoactivatable antagonists of corticotropin-releasing_factor -LRB- CRF -RRB- photoaffinity labeling studies on CRF_receptor , _ type_1 -LRB- CRFR1 -RRB- .
18801728	0	CRFR1	90,95	corticotropin-releasing_factor	25,55	CRFR1	corticotropin-releasing factor	1394	1392	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Molecular recognition of corticotropin-releasing_factor by its G-protein-coupled receptor CRFR1 .
18955489	0	CRFR1	116,121	corticotropin-releasing_factor	73,103	CRFR1	corticotropin-releasing factor	1394	1392	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing_factor receptor 1 -LRB- CRFR1 -RRB- .
9822161	0	CRFR1	75,80	corticotropin-releasing_factor_receptor_type_1	27,73	CRFR1	corticotropin-releasing factor receptor type 1	58959(Tax:10116)	58959(Tax:10116)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of native corticotropin-releasing_factor_receptor_type_1 -LRB- CRFR1 -RRB- in the rat and mouse central nervous system .
18670748	0	CRFR2	58,63	corticotropin_releasing_factor_receptor_2	15,56	CRFR2	corticotropin releasing factor receptor 2	1395	1395	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of corticotropin_releasing_factor_receptor_2 -LRB- CRFR2 -RRB- in the human prostate .
12895416	0	CRF_binding_protein	40,59	Corticotropin-releasing_factor	0,30	CRF binding protein	Corticotropin-releasing factor	1393	1392	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Corticotropin-releasing_factor requires CRF_binding_protein to potentiate NMDA receptors via CRF_receptor_2 in dopamine neurons .
2852510	0	CRH	35,38	ACTH	12,16	CRH	ACTH	1392	5443	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment .
12694378	0	CRH	33,36	Corticotropin-releasing_hormone	0,31	CRH	Corticotropin-releasing hormone	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- expression and protein kinase A mediated CRH receptor signalling in an immortalized hypothalamic cell line .
22703673	0	CRH	33,36	Corticotropin_releasing_hormone	0,31	CRH	Corticotropin releasing hormone	1392	1392	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Corticotropin_releasing_hormone -LRB- CRH -RRB- response in patients with early rheumatoid_arthritis due to polymorphisms in the CRH gene .
15860230	0	CRH	34,37	IL-18	14,19	CRH	IL-18	12918(Tax:10090)	16173(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-18 expression by CRH in mouse microglial cells .
15833364	0	CRH	0,3	POMC	15,19	CRH	POMC	1392	5443	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	CRH stimulates POMC activity and corticosterone production in dermal fibroblasts .
11501060	0	CRH	40,43	angiotensin_II	11,25	CRH	angiotensin II	81648(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_II on release of CRH and AVP from hypothalamus during acute hypoxia .
8910806	0	CRH	10,13	arginine_vasopressin	81,101	CRH	arginine vasopressin	81648(Tax:10116)	24221(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of CRH on the preovulatory LH and FSH surge in the cyclic rat : a role for arginine_vasopressin ?
7820612	0	CRH	29,32	corticosterone	11,25	CRH	corticosterone	81648(Tax:10116)	25305(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY END_ENTITY|nmod|mRNA	Effects of corticosterone on CRH mRNA and content in the bed nucleus of the stria terminalis ; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus .
1664369	0	CRH	114,117	corticotropin-releasing-hormone	81,112	CRH	corticotropin-releasing-hormone	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Endothelin_3 -LRB- ET3 -RRB- stimulates the hypothalamic-pituitary-adrenal_axis mainly by corticotropin-releasing-hormone -LRB- CRH -RRB- -RSB- .
10230640	0	CRH	64,67	corticotropin-releasing_hormone	31,62	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	4-Aryl-2-anilinopyrimidines as corticotropin-releasing_hormone -LRB- CRH -RRB- antagonists .
11287050	0	CRH	43,46	corticotropin-releasing_hormone	10,41	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Decreased corticotropin-releasing_hormone -LRB- CRH -RRB- concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters .
12213307	0	CRH	57,60	corticotropin-releasing_hormone	24,55	CRH	corticotropin-releasing hormone	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Differential release of corticotropin-releasing_hormone -LRB- CRH -RRB- in the amygdala during different types of stressors .
15606911	0	CRH	47,50	corticotropin-releasing_hormone	14,45	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Covariates of corticotropin-releasing_hormone -LRB- CRH -RRB- concentrations in cerebrospinal fluid -LRB- CSF -RRB- from healthy humans .
15882914	0	CRH	199,202	corticotropin-releasing_hormone	166,197	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- mimics neuroendocrine and behavioral manifestations of stress : Evidence for PKA-mediated expression of the corticotropin-releasing_hormone -LRB- CRH -RRB- gene .
15944267	0	CRH	58,61	corticotropin-releasing_hormone	25,56	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Human mast cells express corticotropin-releasing_hormone -LRB- CRH -RRB- receptors and CRH leads to selective secretion of vascular_endothelial_growth_factor .
16416158	0	CRH	159,162	corticotropin-releasing_hormone	126,157	CRH	corticotropin-releasing hormone	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Developmental exposure to corticosterone : behavioral changes and differential effects on leukemia_inhibitory_factor -LRB- LIF -RRB- and corticotropin-releasing_hormone -LRB- CRH -RRB- gene expression in the mouse .
17127497	0	CRH	54,57	corticotropin-releasing_hormone	21,52	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Terbutaline inhibits corticotropin-releasing_hormone -LRB- CRH -RRB- expression in human trophoblast cells .
17507918	0	CRH	69,72	corticotropin-releasing_hormone	36,67	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Ovarian steroid treatment decreases corticotropin-releasing_hormone -LRB- CRH -RRB- mRNA and protein in the hypothalamic paraventricular nucleus of ovariectomized monkeys .
20006448	0	CRH	58,61	corticotropin-releasing_hormone	25,56	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of maternal serum corticotropin-releasing_hormone -LRB- CRH -RRB- at midpregnancy in relation to maternal characteristics .
2093479	0	CRH	44,47	corticotropin-releasing_hormone	11,42	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of corticotropin-releasing_hormone -LRB- CRH -RRB- in maternal and fetal plasma and in amniotic fluid .
2176309	0	CRH	84,87	corticotropin-releasing_hormone	51,82	CRH	corticotropin-releasing hormone	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Effects of cortisol treatment on brain and adrenal corticotropin-releasing_hormone -LRB- CRH -RRB- content and other parameters regulated by CRH .
21765902	0	CRH	60,63	corticotropin-releasing_hormone	27,58	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role of peripheral corticotropin-releasing_hormone -LRB- CRH -RRB- on dermal fibroblasts .
2401449	0	CRH	51,54	corticotropin-releasing_hormone	18,49	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the corticotropin-releasing_hormone -LRB- CRH -RRB- gene in human placenta and amniotic membrane .
7951540	0	CRH	44,47	corticotropin-releasing_hormone	11,42	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Low plasma corticotropin-releasing_hormone -LRB- CRH -RRB- levels in patients with non-insulin_dependent_diabetes_mellitus -LRB- NIDDM -RRB- .
9476637	0	CRH	47,50	corticotropin-releasing_hormone	14,45	CRH	corticotropin-releasing hormone	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of corticotropin-releasing_hormone -LRB- CRH -RRB- on the adrenal medulla in hypophysectomized rats .
9506767	0	CRH	53,56	corticotropin-releasing_hormone	20,51	CRH	corticotropin-releasing hormone	1392	1392	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of corticotropin-releasing_hormone -LRB- CRH -RRB- in human skin .
11939721	0	CRH	50,53	corticotropin_releasing_hormone	17,48	CRH	corticotropin releasing hormone	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of the corticotropin_releasing_hormone -LRB- CRH -RRB- on the brain-blood barrier permeability in cerebral_ischemia in rats .
16309788	0	CRH	124,127	corticotropin_releasing_hormone	91,122	CRH	corticotropin releasing hormone	1392	1392	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin_releasing_hormone -LRB- CRH -RRB- : priming the placental clock .
9026271	0	CRH	57,60	corticotropin_releasing_hormone	24,55	CRH	corticotropin releasing hormone	1392	1392	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Differential changes of corticotropin_releasing_hormone -LRB- CRH -RRB- concentrations in plasma and synovial fluids of patients with rheumatoid_arthritis -LRB- RA -RRB- .
22006535	0	CRH-BP	96,102	corticotropin-releasing_hormone-binding_protein	47,94	CRH-BP	corticotropin-releasing hormone-binding protein	409372(Tax:7460)	409372(Tax:7460)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of a novel corticotropin-releasing_hormone-binding_protein -LRB- CRH-BP -RRB- gene from Chinese honeybee -LRB- Apis_cerana cerana -RRB- .
11796746	0	CRH-BP	78,84	corticotropin-releasing_hormone_binding_protein	29,76	CRH-BP	corticotropin-releasing hormone binding protein	29625(Tax:10116)	29625(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of corticotropin-releasing_hormone_binding_protein -LRB- CRH-BP -RRB- in rat adrenals .
10367986	0	CRH-R	60,65	corticotropin-releasing_hormone_receptor	18,58	CRH-R	corticotropin-releasing hormone receptor	12921(Tax:10090)	12921(Tax:10090)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	The rationale for corticotropin-releasing_hormone_receptor -LRB- CRH-R -RRB- antagonists to treat depression and anxiety .
8600981	0	CRH-R	94,99	corticotropin_releasing_hormone_receptor	52,92	CRH-R	corticotropin releasing hormone receptor	12921(Tax:10090)	12921(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The expression of proopiomelanocortin -LRB- POMC -RRB- and of corticotropin_releasing_hormone_receptor -LRB- CRH-R -RRB- genes in mouse skin .
18805429	0	CRH-R1	40,46	Corticotropin-releasing_hormone	0,31	CRH-R1	Corticotropin-releasing hormone	1394	1392	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Corticotropin-releasing_hormone acts on CRH-R1 to inhibit the spontaneous contractility of non-labouring human myometrium at term .
16424794	0	CRH-receptor_subtype_R1_and_R2	83,113	corticotropin-releasing_hormone	11,42	CRH-receptor subtype R1 and R2	corticotropin-releasing hormone	913	1392	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Effects of corticotropin-releasing_hormone -LRB- CRH -RRB- on monocyte function , mediated by CRH-receptor_subtype_R1_and_R2 : a potential link between mood_disorders and endothelial_dysfunction ?
15992556	0	CRHR1	111,116	corticotropin_releasing_hormone_receptor_1	67,109	CRHR1	corticotropin releasing hormone receptor 1	1394	1394	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between single nucleotide polymorphisms in the corticotropin_releasing_hormone_receptor_1 -LRB- CRHR1 -RRB- gene and alcohol_dependence .
16550213	0	CRHR1	77,82	corticotropin_releasing_hormone_receptor_1	33,75	CRHR1	corticotropin releasing hormone receptor 1	1394	1394	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Genetic association of the human corticotropin_releasing_hormone_receptor_1 -LRB- CRHR1 -RRB- with binge drinking and alcohol intake patterns in two independent samples .
11857585	0	CRHR2	92,97	corticotropin-releasing_hormone_receptor-2	48,90	CRHR2	corticotropin-releasing hormone receptor-2	1395	1395	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Gene-based SNP genetic association study of the corticotropin-releasing_hormone_receptor-2 -LRB- CRHR2 -RRB- in major depression .
16884458	0	CRHR2	64,69	corticotropin-releasing_hormone_receptor_2	20,62	CRHR2	corticotropin-releasing hormone receptor 2	1395	1395	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between corticotropin-releasing_hormone_receptor_2 -LRB- CRHR2 -RRB- gene polymorphism and personality traits .
18706413	0	CRHR2	67,72	corticotropin-releasing_hormone_receptor_2	23,65	CRHR2	corticotropin-releasing hormone receptor 2	64680(Tax:10116)	64680(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen regulation of corticotropin-releasing_hormone_receptor_2 -LRB- CRHR2 -RRB- mRNA expression and receptor binding in the rat brain .
26363222	0	CRH_type_1_receptor	127,146	Corticotropin-releasing_hormone	0,31	CRH type 1 receptor	Corticotropin-releasing hormone	374218(Tax:9031)	404297(Tax:9031)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- stimulates cocaine - _ and_amphetamine-regulated_transcript gene -LRB- CART1 -RRB- expression through CRH_type_1_receptor -LRB- CRHR1 -RRB- in chicken anterior pituitary .
23570421	0	CRIP1	50,55	cysteine-rich_intestinal_protein_1	14,48	CRIP1	cysteine-rich intestinal protein 1	1396	1396	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	The impact of cysteine-rich_intestinal_protein_1 -LRB- CRIP1 -RRB- in human breast_cancer .
26934316	0	CRIP2	57,62	MiR-449a	0,8	CRIP2	MiR-449a	1397	554213	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-449a promotes breast_cancer progression by targeting CRIP2 .
9020862	0	CRISP-1	98,105	cysteine-rich_secretory_protein-1	63,96	CRISP-1	cysteine-rich secretory protein-1	11571(Tax:10090)	11571(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the androgen-dependent mouse cysteine-rich_secretory_protein-1 -LRB- CRISP-1 -RRB- gene .
15950934	0	CRISP-3	30,37	beta-Microseminoprotein	0,23	CRISP-3	beta-Microseminoprotein	10321	4477	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	beta-Microseminoprotein binds CRISP-3 in human seminal plasma .
7639699	0	CRISP-3	98,105	cysteine-rich_secretory_protein-3	63,96	CRISP-3	cysteine-rich secretory protein-3	11572(Tax:10090)	11572(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the androgen-dependent mouse cysteine-rich_secretory_protein-3 -LRB- CRISP-3 -RRB- gene .
15867000	0	CRISP-3	72,79	cysteine-rich_secretory_protein_3	37,70	CRISP-3	cysteine-rich secretory protein 3	10321	10321	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization and localization of cysteine-rich_secretory_protein_3 -LRB- CRISP-3 -RRB- in the human male reproductive tract .
18703418	0	CRISP1	56,62	protein_D	19,28	CRISP1	protein D	64827(Tax:10116)	64827(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the protein_D and protein E forms of rat CRISP1 with epididymal sperm .
21529916	0	CRISP2	15,21	CCT8	23,27	CRISP2	CCT8	512443(Tax:9913)	281047(Tax:9913)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Association of CRISP2 , CCT8 , PEBP1 mRNA abundance in sperm and sire_conception_rate in Holstein bulls .
21529916	0	CRISP2	15,21	PEBP1	29,34	CRISP2	PEBP1	512443(Tax:9913)	618233(Tax:9913)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Association of CRISP2 , CCT8 , PEBP1 mRNA abundance in sperm and sire_conception_rate in Holstein bulls .
18550510	0	CRISP2	62,68	cysteine-rich_secretory_protein_2	27,60	CRISP2	cysteine-rich secretory protein 2	7180	7180	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the human cysteine-rich_secretory_protein_2 -LRB- CRISP2 -RRB- gene in Australian men .
24955763	0	CRISPLD2	0,8	progesterone_receptor	24,45	CRISPLD2	progesterone receptor	83716	5241	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	CRISPLD2 is a target of progesterone_receptor and its expression is decreased in women with endometriosis .
17051150	0	CRIg	33,37	C3b	13,16	CRIg	C3b	11326	718	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structure of C3b in complex with CRIg gives insights into regulation of complement activation .
16076871	0	CRK	22,25	VEGFR-3	38,45	CRK	VEGFR-3	1398	2324	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation , migration , and survival of endothelial cells through the activation of ERK , AKT , and JNK pathways .
8810278	0	CRKL	59,63	BCR/ABL	106,113	CRKL	BCR/ABL	1399	25;613	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nmod|cells cells|acl|transformed transformed|nmod|oncogene oncogene|compound|END_ENTITY	p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene .
9053848	0	CRKL	16,20	BCR/ABL	28,35	CRKL	BCR/ABL	12929(Tax:10090)	110279(Tax:10090)	Gene	Gene	Tyrosine|nmod|START_ENTITY site|nsubj|Tyrosine site|amod|END_ENTITY	Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site .
9067577	0	CRKL	64,68	BCR/ABL	4,11	CRKL	BCR/ABL	1399	25	Gene	Gene	interaction|nmod|START_ENTITY alters|dobj|interaction alters|nsubj|oncogene oncogene|compound|END_ENTITY	The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins .
9092574	0	CRKL	49,53	CRKL	69,73	CRKL	CRKL	1399	1399	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
9092574	0	CRKL	69,73	CRKL	49,53	CRKL	CRKL	1399	1399	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
9092574	0	CRKL	49,53	Steel_factor	0,12	CRKL	Steel factor	1399	4254	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
9092574	0	CRKL	69,73	Steel_factor	0,12	CRKL	Steel factor	1399	4254	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
8810278	0	CRKL	59,63	p130CAS	0,7	CRKL	p130CAS	1399	9564	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene .
23109433	0	CRL4	0,4	CHK1	19,23	CRL4	CHK1	55540	1111	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	CRL4 -LRB- CDT2 -RRB- targets CHK1 for PCNA-independent destruction .
26909574	0	CRL4	65,69	CRBN	70,74	CRL4	CRBN	55540	51185	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Structural basis of lenalidomide-induced CK1a degradation by the CRL4 -LRB- CRBN -RRB- ubiquitin ligase .
19641190	0	CRLF2	50,55	cytokine_receptor	26,43	CRLF2	cytokine receptor	64109	8809	Gene	Gene	expression|appos|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	Deregulated expression of cytokine_receptor gene , CRLF2 , is involved in lymphoid transformation in B-cell precursor acute_lymphoblastic_leukemia .
14747444	0	CRLR	73,77	calcitonin_receptor-like_receptor	38,71	CRLR	calcitonin receptor-like receptor	10203	10203	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The immunohistochemical expression of calcitonin_receptor-like_receptor -LRB- CRLR -RRB- in human gliomas .
10766770	0	CRM1	46,50	An3	31,34	CRM1	An3	399087(Tax:8355)	397935(Tax:8355)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Nuclear export of the DEAD box An3 protein by CRM1 is coupled to An3 helicase activity .
15367634	0	CRM1	66,70	NS2	74,77	CRM1	NS2	103573(Tax:10090)	57762	Gene	Gene	START_ENTITY|nmod|mutations mutations|nummod|END_ENTITY	Enhanced cytoplasmic sequestration of the nuclear export receptor CRM1 by NS2 mutations developed in the host regulates parvovirus fitness .
26091065	0	CRM1	68,72	Nucleophosmin	33,46	CRM1	Nucleophosmin	7514	4869	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|compound|END_ENTITY	Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1 : Molecular Basis of Aberrant Transport .
10330396	0	CRM1	36,40	RanBP1	11,17	CRM1	RanBP1	7514	5902	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	A role for RanBP1 in the release of CRM1 from the nuclear_pore_complex in a terminal step of nuclear export .
21378169	0	CRM1	61,65	Skp1	40,44	CRM1	Skp1	7514	6500	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	A Competitive binding mechanism between Skp1 and exportin_1 -LRB- CRM1 -RRB- controls the localization of a subset of F-box proteins .
24595136	0	CRM1	62,66	chromosome_region_maintenance_1	29,60	CRM1	chromosome region maintenance 1	103573(Tax:10090)	103573(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Antitumor effects of a novel chromosome_region_maintenance_1 -LRB- CRM1 -RRB- inhibitor on non-small_cell_lung_cancer cells in vitro and in mouse tumor xenografts .
25148895	0	CRM1	48,52	chromosome_region_maintenance_1	15,46	CRM1	chromosome region maintenance 1	7514	7514	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of chromosome_region_maintenance_1 -LRB- CRM1 -RRB- in the formation and progression of esophageal_squamous_cell_carcinoma .
14612415	0	CRM1	34,38	exportin_1	40,50	CRM1	exportin 1	7514	7514	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	A multifunctional domain in human CRM1 -LRB- exportin_1 -RRB- mediates RanBP3 binding and multimerization of human_T-cell_leukemia_virus_type_1 Rex protein .
9658105	0	CRM1	21,25	exportin_1	27,37	CRM1	exportin 1	7514	7514	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of human CRM1 -LRB- exportin_1 -RRB- in the export and multimerization of the Rex protein of human_T-cell_leukemia_virus_type_1 .
19574837	0	CRM1	14,18	p27	60,63	CRM1	p27	7514	10534	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|expression expression|amod|END_ENTITY	Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis .
18524846	0	CRMP-1	56,62	cyclooxygenase-2	66,82	CRMP-1	cyclooxygenase-2	1400	5743	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha .
15207709	0	CRMP-2	13,19	GDNF	23,27	CRMP-2	GDNF	1808	2668	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region .
19755421	0	CRMP-2	60,66	collapsin_response_mediator_protein_2	21,58	CRMP-2	collapsin response mediator protein 2	1808	1808	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	An atypical role for collapsin_response_mediator_protein_2 -LRB- CRMP-2 -RRB- in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels .
18598844	0	CRMP-4	39,45	Collapsin_response_mediator_protein-4	0,37	CRMP-4	Collapsin response mediator protein-4	1809	1809	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Collapsin_response_mediator_protein-4 -LRB- CRMP-4 -RRB- expression in posthaching development of song control nuclei in Bengalese finches .
16230462	0	CRMP2	43,48	GSK-3	14,19	CRMP2	GSK-3	12934(Tax:10090)	56637(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of GSK-3 and phosphorylation of CRMP2 in transgenic_mice expressing APP intracellular domain .
15676027	0	CRMP2	88,93	GSK3beta	60,68	CRMP2	GSK3beta	12934(Tax:10090)	56637(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2 : implication of common phosphorylating mechanism underlying axon guidance and Alzheimer 's _ disease .
20926379	0	CRMP2	19,24	bone_morphogenetic_protein	39,65	CRMP2	bone morphogenetic protein	1808	649	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	The suppression of CRMP2 expression by bone_morphogenetic_protein -LRB- BMP -RRB- - SMAD gradient signaling controls multiple stages of neuronal development .
22279220	0	CRMP2	19,24	collapsin_response_mediator_protein_2	26,63	CRMP2	collapsin response mediator protein 2	12934(Tax:10090)	12934(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of CRMP2 -LRB- collapsin_response_mediator_protein_2 -RRB- is involved in proper dendritic field organization .
24904280	0	CRMP2	66,71	collapsin_response_mediator_protein_2	27,64	CRMP2	collapsin response mediator protein 2	1808	1808	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of collapsin_response_mediator_protein_2 -LRB- CRMP2 -RRB- phosphorylation by GSK3 and CDK5 following traumatic_brain_injury .
23568759	0	CRMP4	65,70	DPYSL3	57,63	CRMP4	DPYSL3	1809	1809	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A rare motor neuron deleterious missense mutation in the DPYSL3 -LRB- CRMP4 -RRB- gene is associated with ALS .
20410116	0	CRMP4	71,76	GSK3_beta	0,9	CRMP4	GSK3 beta	1809	2932	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	GSK3_beta regulates myelin-dependent axon outgrowth inhibition through CRMP4 .
25040932	0	CRMP5	39,44	Collapsin_response-mediator_protein_5	0,37	CRMP5	Collapsin response-mediator protein 5	65208(Tax:10116)	65208(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Collapsin_response-mediator_protein_5 -LRB- CRMP5 -RRB- phosphorylation at threonine 516 regulates neurite outgrowth inhibition .
12840007	0	CRN-1	0,5	FEN-1	32,37	CRN-1	FEN-1	171917(Tax:6239)	2237	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	CRN-1 , a Caenorhabditis_elegans FEN-1 homologue , cooperates with CPS-6 / EndoG to promote apoptotic DNA degradation .
10379687	0	CRP	20,23	C-reactive_protein	0,18	CRP	C-reactive protein	20468888	20468888	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- response patterns in neonatal_septicaemia .
10880233	0	CRP	126,129	C-reactive_protein	106,124	CRP	C-reactive protein	12944(Tax:10090)	12944(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Role of STAT3 and C/EBP in cytokine-dependent expression of the mouse serum_amyloid_P-component -LRB- SAP -RRB- and C-reactive_protein -LRB- CRP -RRB- genes .
11947917	0	CRP	46,49	C-reactive_protein	26,44	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the human C-reactive_protein -LRB- CRP -RRB- gene , plasma concentrations of CRP , and the risk of future arterial thrombosis .
14625403	0	CRP	43,46	C-reactive_protein	23,41	CRP	C-reactive protein	488629(Tax:9615)	488629(Tax:9615)	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of serum C-reactive_protein -LRB- CRP -RRB- in healthy beagle_dogs of various ages and pregnant beagle_dogs .
15504106	0	CRP	78,81	C-reactive_protein	58,76	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Persistent endothelial_dysfunction is related to elevated C-reactive_protein -LRB- CRP -RRB- levels in Type_II_diabetic patients after acute_myocardial_infarction .
15542929	0	CRP	26,29	C-reactive_protein	6,24	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum C-reactive_protein -LRB- CRP -RRB- levels and insulin resistance in non-obese women with polycystic_ovarian_syndrome , and effect of bicalutamide on hirsutism , CRP levels and insulin resistance .
15778807	0	CRP	59,62	C-reactive_protein	39,57	CRP	C-reactive protein	1401	1401	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Single-nucleotide polymorphisms in the C-reactive_protein -LRB- CRP -RRB- gene promoter that affect transcription factor binding , alter transcriptional activity , and associate with differences in baseline serum CRP level .
15889566	0	CRP	44,47	C-reactive_protein	24,42	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The prognostic value of C-reactive_protein -LRB- CRP -RRB- levels in patients with acute ischaemic_stroke .
15897982	0	CRP	45,48	C-reactive_protein	25,43	CRP	C-reactive protein	1401	1401	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Polymorphisms within the C-reactive_protein -LRB- CRP -RRB- promoter region are associated with plasma CRP levels .
16832152	0	CRP	40,43	C-reactive_protein	20,38	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism of the C-reactive_protein -LRB- CRP -RRB- gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese .
16984505	0	CRP	53,56	C-reactive_protein	33,51	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The +1059 G/C polymorphism in the C-reactive_protein -LRB- CRP -RRB- gene is associated with involvement of the terminal ileum and decreased serum CRP levels in patients with Crohn 's _ disease .
1735220	0	CRP	20,23	C-reactive_protein	0,18	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	C-reactive_protein -LRB- CRP -RRB- levels after elective orthopedic surgery .
17395501	0	CRP	44,47	C-reactive_protein	24,42	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Interpretation of serum C-reactive_protein -LRB- CRP -RRB- levels for cardiovascular_disease risk is complicated by race , pulmonary_disease , body mass index , gender , and osteoarthritis .
17477779	0	CRP	47,50	C-reactive_protein	27,45	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Associations between serum C-reactive_protein -LRB- CRP -RRB- levels and polymorphisms of CRP , _ interleukin_1B , and tumor necrosis factor genes among Japanese health checkup examinees .
18083122	0	CRP	46,49	C-reactive_protein	26,44	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the human C-reactive_protein -LRB- CRP -RRB- gene , serum concentrations of CRP , and the difference between intracranial and extracranial atherosclerosis .
1810225	0	CRP	31,34	C-reactive_protein	11,29	CRP	C-reactive protein	1401	1401	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of C-reactive_protein -LRB- CRP -RRB- by human peripheral blood lymphocytes in vivo .
18167554	0	CRP	20,23	C-reactive_protein	0,18	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- gene polymorphisms , CRP levels , and risk of incident coronary_heart_disease in two nested case-control studies .
18266777	0	CRP	33,36	C-reactive_protein	13,31	CRP	C-reactive protein	1401	1401	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	No effect of C-reactive_protein -LRB- CRP -RRB- haplotypes on CRP levels and post-transplant morbidity and mortality in renal transplantation .
18793001	0	CRP	41,44	C-reactive_protein	21,39	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variation in C-reactive_protein -LRB- CRP -RRB- gene may be associated with risk of systemic_lupus_erythematosus and CRP concentrations .
19373547	0	CRP	26,29	C-reactive_protein	6,24	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum C-reactive_protein -LRB- CRP -RRB- levels in cancer patients are linked with tumor burden and are reduced by anti-hypertensive medication .
19410251	0	CRP	35,38	C-reactive_protein	15,33	CRP	C-reactive protein	1401	1401	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of C-reactive_protein -LRB- CRP -RRB- gene allelic variants with serum CRP levels and hypertension in Turkish adults .
19624831	0	CRP	47,50	C-reactive_protein	27,45	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional analysis of the C-reactive_protein -LRB- CRP -RRB- gene -717 A > G polymorphism associated with coronary_heart_disease .
20552244	0	CRP	48,51	C-reactive_protein	28,46	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic polymorphism of the C-reactive_protein -LRB- CRP -RRB- gene and a deep_infection focus determine maximal serum CRP level in Staphylococcus_aureus bacteremia .
21413847	0	CRP	40,43	C-reactive_protein	20,38	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the C-reactive_protein -LRB- CRP -RRB- gene affects CRP levels in plasma and one early marker of atherosclerosis in men : The Health 2000 Survey .
21720757	0	CRP	20,23	C-reactive_protein	0,18	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- gene polymorphisms : implication in CRP plasma levels and susceptibility to acute_myocardial_infarction .
21737650	0	CRP	35,38	C-reactive_protein	15,33	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of C-reactive_protein -LRB- CRP -RRB- gene polymorphisms , serum CRP levels and cervical_cancer prognosis .
22467322	0	CRP	52,55	C-reactive_protein	32,50	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Comparative evaluation of serum C-reactive_protein -LRB- CRP -RRB- levels in the different histological subtypes of esophageal_cancer -LRB- squamous_cell_carcinoma and adenocarcinoma_of_esophagus -RRB- .
22926497	0	CRP	26,29	C-reactive_protein	6,24	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum C-reactive_protein -LRB- CRP -RRB- levels in young adults can be used to discriminate between inflammatory and non-inflammatory_diarrhea .
23529581	0	CRP	20,23	C-reactive_protein	0,18	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- levels in babies with gastroschisis managed with preformed silos .
23818401	0	CRP	44,47	C-reactive_protein	24,42	CRP	C-reactive protein	1401	1401	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association between C-reactive_protein -LRB- CRP -RRB- level and biochemical failure-free survival in patients after radiation therapy for nonmetastatic adenocarcinoma_of_the_prostate .
25495587	0	CRP	30,33	C-reactive_protein	10,28	CRP	C-reactive protein	1401	1401	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of C-reactive_protein -LRB- CRP -RRB- in patients with schizophrenia , unipolar_depression and bipolar_disorder .
2593200	0	CRP	30,33	C-reactive_protein	10,28	CRP	C-reactive protein	1401	1401	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of C-reactive_protein -LRB- CRP -RRB- on surfactant function .
27068411	0	CRP	42,45	C-reactive_protein	22,40	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Short-term changes on C-reactive_protein -LRB- CRP -RRB- levels after non-surgical periodontal treatment in systemically healthy individuals .
3485499	0	CRP	20,23	C-reactive_protein	0,18	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- levels in systemic_lupus_erythematosus -LRB- SLE -RRB- .
3759147	0	CRP	35,38	C-reactive_protein	10,28	CRP	C-reactive protein	1401	1401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human C-reactive_protein gene -LRB- CRP -RRB- and serum_amyloid_P_component gene -LRB- APCS -RRB- are located on the proximal long arm of chromosome 1 .
6524861	0	CRP	33,36	C-reactive_protein	13,31	CRP	C-reactive protein	1401	1401	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The value of C-reactive_protein -LRB- CRP -RRB- determinations in patients with suspected acute_appendicitis .
8339052	0	CRP	20,23	C-reactive_protein	0,18	CRP	C-reactive protein	1401	1401	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- levels do not reflect disease status in patients with multiple_myeloma .
23688010	0	CRP	28,31	C_reactive_protein	8,26	CRP	C reactive protein	1401	1401	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of C_reactive_protein -LRB- CRP -RRB- in leptin resistance .
16804660	0	CRP	124,127	IL-18	32,37	CRP	IL-18	1401	3606	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of interleukin-18 -LRB- IL-18 -RRB- , interleukin-1beta -LRB- IL-1beta -RRB- , its soluble receptor sIL-1RII and C-reactive_protein -LRB- CRP -RRB- in patients with Lyme_arthritis .
15668089	0	CRP	71,74	IL-6	0,4	CRP	IL-6	1401	3569	Gene	Gene	relation|acl|START_ENTITY levels|dep|relation levels|compound|END_ENTITY	IL-6 levels in acute and post myocardial_infarction : their relation to CRP levels , infarction size , left ventricular systolic function , and heart_failure .
17141340	0	CRP	0,3	IL-6	5,9	CRP	IL-6	1401	3569	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	CRP , IL-6 and endothelin-1 levels in patients undergoing coronary artery bypass grafting .
2001421	0	CRP	112,115	IL-6	63,67	CRP	IL-6	1401	3569	Gene	Gene	C-reactive_protein|appos|START_ENTITY synthesis|nmod|C-reactive_protein stimulated|dobj|synthesis interleukin|acl|stimulated interleukin|amod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- inhibits interleukin -LRB- IL -RRB- -1 and/or IL-6 stimulated synthesis of C-reactive_protein -LRB- CRP -RRB- and serum_amyloid_A -LRB- SAA -RRB- in primary cultures of human hepatocytes .
20568512	0	CRP	26,29	IL-6	20,24	CRP	IL-6	1401	3569	Gene	Gene	measurement|appos|START_ENTITY measurement|appos|END_ENTITY	-LSB- Usefulness of PCT , IL-6 , CRP measurement in the prediction of intraamniotic_infection and newborn status in pregnant women with premature_rupture of membranes -RSB- .
20626020	0	CRP	76,79	IL-6	46,50	CRP	IL-6	1401	3569	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Diagnostic usefulness of serum interleukin_6 -LRB- IL-6 -RRB- and C-reactive_protein -LRB- CRP -RRB- in the differentiation between pancreatic_cancer and chronic_pancreatitis .
21031427	0	CRP	15,18	IL-6	112,116	CRP	IL-6	1401	3569	Gene	Gene	levels|compound|START_ENTITY reflect|nsubj|levels reflect|nmod|END_ENTITY	Elevated serum CRP levels after induction chemoradiotherapy reflect poor treatment response in association with IL-6 in serum and local tumor site in patients with advanced esophageal_cancer .
22983415	0	CRP	61,64	IL-6	31,35	CRP	IL-6	1401	3569	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Significance of interleukin-6 -LRB- IL-6 -RRB- and C-reactive_protein -LRB- CRP -RRB- in children and young adults with febrile_neutropenia during chemotherapy for cancer : a prospective study .
23763486	0	CRP	66,69	IL-6	37,41	CRP	IL-6	12944(Tax:10090)	16193(Tax:10090)	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Acrolein stimulates the synthesis of IL-6 and C-reactive_protein -LRB- CRP -RRB- in thrombosis model mice and cultured cells .
25671204	0	CRP	82,85	IL-6	52,56	CRP	IL-6	1401	3569	Gene	Gene	Interleukin-6|appos|START_ENTITY Interleukin-6|appos|END_ENTITY	Effect of different training mode on Interleukin-6 -LRB- IL-6 -RRB- and C-reactive_protein -LRB- CRP -RRB- in type_2_diabetes_mellitus -LRB- T2DM -RRB- patients .
26520627	0	CRP	26,29	IL-6	20,24	CRP	IL-6	1401	3569	Gene	Gene	WBC|appos|START_ENTITY WBC|compound|END_ENTITY	Diagnostic Value of IL-6 , CRP , WBC , and Absolute Neutrophil Count to Predict Serious Bacterial_Infection in Febrile Infants .
18392379	0	CRP	85,88	Il-6	31,35	CRP	Il-6	1401	3569	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of interleukin-6 -LRB- Il-6 -RRB- , interleukin-18 -LRB- Il-18 -RRB- and C-reactive_protein -LRB- CRP -RRB- in patients with type-2 diabetes and acute_coronary_syndrome without ST-segment elevation .
22142512	0	CRP	0,3	MMP-10	13,19	CRP	MMP-10	1401	4319	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	CRP promotes MMP-10 expression via c-Raf/MEK/ERK and JAK1/ERK pathways in cardiomyocytes .
22997483	0	CRP	0,3	PAPP-A	26,32	CRP	PAPP-A	1401	5069	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	CRP and TNF-a induce PAPP-A expression in human peripheral blood mononuclear cells .
25605194	0	CRP	76,79	TNF-a	69,74	CRP	TNF-a	1401	7124	Gene	Gene	Levels|dep|START_ENTITY Levels|dep|END_ENTITY	Effect of Intraoperative Glucose Fluctuation and Postoperative IL-6 , TNF-a , CRP Levels on the Short-term Prognosis of Patients with Intracranial Supratentorial_Neoplasms .
26524038	0	CRP	49,52	TNF-a	42,47	CRP	TNF-a	1401	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|amod|END_ENTITY	-LSB- Values of Detecting the Levels of b2-MG , TNF-a , CRP , IL-6 in the Patients with Multiple_Myeloma -RSB- .
1327124	0	CRP	51,54	cAMP_receptor_protein	28,49	CRP	cAMP receptor protein	20468888	20468888	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Transcription activation by cAMP_receptor_protein -LRB- CRP -RRB- at the Escherichia_coli gal P1 promoter .
12454230	0	CRP	79,82	cardiac_troponin_T	9,27	CRP	cardiac troponin T	1401	7139	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Elevated cardiac_troponin_T in peritoneal_dialysis patients is associated with CRP and predicts all-cause mortality and cardiac_death .
9867350	0	CRP	39,42	cysteine-rich_protein	16,37	CRP	cysteine-rich protein	429786(Tax:9031)	429786(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of a cysteine-rich_protein -LRB- CRP -RRB- encoding gene during early development of the trout .
22822613	0	CRP	15,18	fibrinogen	38,48	CRP	fibrinogen	1401	2244	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of CRP and serum level of fibrinogen with severity of disease in chronic_obstructive_pulmonary_disease patients .
8818087	0	CRP	42,45	ulinastatin	20,31	CRP	ulinastatin	1401	259	Gene	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	-LSB- Changes of urinary ulinastatin and serum CRP after elective surgery for gastric_cancer -RSB- .
9314536	0	CRP1	0,4	alpha-actinin	80,93	CRP1	alpha-actinin	1396	87	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CRP1 , a LIM domain protein implicated in muscle differentiation , interacts with alpha-actinin .
18713466	0	CRP2	103,107	Csrp2	33,38	CRP2	Csrp2	13008(Tax:10090)	13008(Tax:10090)	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	Targeted disruption of the mouse Csrp2 gene encoding the cysteine - and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure .
23725563	0	CRR6	35,39	Slr1097	49,56	CRR6	Slr1097	819403(Tax:3702)	953375(Tax:1148)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of a cyanobacterial CRR6 protein , Slr1097 , required for efficient assembly of NDH-1 complexes in Synechocystis_sp .
12825353	0	CRSP2	76,81	EXLM1	83,88	CRSP2	EXLM1	9282	9282	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Refinement of the physical location and the genomic characterization of the CRSP2 -LRB- EXLM1 -RRB- gene on Xp11 .4 .
25398213	0	CRT	76,79	calreticulin	62,74	CRT	calreticulin	811	125972	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterisation and expression analysis of a novel calreticulin -LRB- CRT -RRB- gene in the dinoflagellate Prorocentrum minimum .
25910959	0	CRTAM	0,5	ZEB1	33,37	CRTAM	ZEB1	56253	6935	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	CRTAM is negatively regulated by ZEB1 in T cells .
22051697	0	CRTAM	94,99	class_I_MHC-restricted_T_cell-associated_molecule	38,87	CRTAM	class I MHC-restricted T cell-associated molecule	56253	56253	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genome-wide association study reveals class_I_MHC-restricted_T_cell-associated_molecule gene -LRB- CRTAM -RRB- variants interact with vitamin_D levels to affect asthma exacerbations .
19381067	0	CRTC2	42,47	Adiponectin	0,11	CRTC2	Adiponectin	200186	9370	Gene	Gene	START_ENTITY|nsubj|targets targets|compound|END_ENTITY	Adiponectin and thiazolidinedione targets CRTC2 to regulate hepatic gluconeogenesis .
26147081	0	CRTC2	21,26	SREBP1	75,81	CRTC2	SREBP1	74343(Tax:10090)	20787(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|END_ENTITY	The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1 .
17067313	0	CRTH2	107,112	CD4	148,151	CRTH2	CD4	11251	920	Gene	Gene	cells|appos|START_ENTITY cells|nmod|chemotaxis chemotaxis|nmod|Th2 Th2|compound|END_ENTITY	A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 -LRB- Th2 -RRB- cells -LRB- CRTH2 -RRB- in mediating chemotaxis of CRTH2 + CD4 + Th2 lymphocytes in response to mast cell supernatants .
17067313	0	CRTH2	141,146	CD4	148,151	CRTH2	CD4	11251	920	Gene	Gene	Th2|compound|START_ENTITY Th2|compound|END_ENTITY	A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 -LRB- Th2 -RRB- cells -LRB- CRTH2 -RRB- in mediating chemotaxis of CRTH2 + CD4 + Th2 lymphocytes in response to mast cell supernatants .
17437532	0	CRTH2	102,107	CD4	155,158	CRTH2	CD4	11251	920	Gene	Gene	role|appos|START_ENTITY role|acl|mediating mediating|dobj|activation activation|nmod|T T|compound|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
17437532	0	CRTH2	148,153	CD4	155,158	CRTH2	CD4	11251	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
17067313	0	CRTH2	107,112	CRTH2	141,146	CRTH2	CRTH2	11251	11251	Gene	Gene	cells|appos|START_ENTITY cells|nmod|chemotaxis chemotaxis|nmod|Th2 Th2|compound|END_ENTITY	A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 -LRB- Th2 -RRB- cells -LRB- CRTH2 -RRB- in mediating chemotaxis of CRTH2 + CD4 + Th2 lymphocytes in response to mast cell supernatants .
17067313	0	CRTH2	141,146	CRTH2	107,112	CRTH2	CRTH2	11251	11251	Gene	Gene	Th2|compound|START_ENTITY chemotaxis|nmod|Th2 cells|nmod|chemotaxis cells|appos|END_ENTITY	A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 -LRB- Th2 -RRB- cells -LRB- CRTH2 -RRB- in mediating chemotaxis of CRTH2 + CD4 + Th2 lymphocytes in response to mast cell supernatants .
17437532	0	CRTH2	102,107	CRTH2	148,153	CRTH2	CRTH2	11251	11251	Gene	Gene	role|appos|START_ENTITY role|acl|mediating mediating|dobj|activation activation|nmod|T T|compound|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
17437532	0	CRTH2	148,153	CRTH2	102,107	CRTH2	CRTH2	11251	11251	Gene	Gene	T|compound|START_ENTITY activation|nmod|T mediating|dobj|activation role|acl|mediating role|appos|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
18318469	0	CRTH2	71,76	DP2	78,81	CRTH2	DP2	11251	11251	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of a new class of potent , selective , and orally bioavailable CRTH2 -LRB- DP2 -RRB- receptor antagonists for the treatment of allergic inflammatory diseases .
21916510	0	CRTH2	82,87	DP2	89,92	CRTH2	DP2	11251	11251	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Discovery of potent , selective , and orally bioavailable alkynylphenoxyacetic_acid CRTH2 -LRB- DP2 -RRB- receptor antagonists for the treatment of allergic inflammatory diseases .
24900284	0	CRTH2	31,36	DP2	38,41	CRTH2	DP2	11251	11251	Gene	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Discovery of a Novel Series of CRTH2 -LRB- DP2 -RRB- Receptor Antagonists Devoid of Carboxylic_Acids .
24900359	0	CRTH2	65,70	DP2	72,75	CRTH2	DP2	11251	11251	Gene	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Optimization of the Central Core of Indolinone-Acetic_Acid-Based CRTH2 -LRB- DP2 -RRB- Receptor Antagonists .
18212515	0	CRTH2	0,5	PGD2	58,62	CRTH2	PGD2	11251	5730	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|effect effect|nmod|END_ENTITY	CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine .
17437532	0	CRTH2	102,107	chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells	21,100	CRTH2	chemoattractant receptor-homologous molecule expressed on T helper type 2 cells	11251	11251	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
17196174	0	CRTH2	115,120	chemoattractant_receptor-homologous_molecule_expressed_on_Th2_cells	46,113	CRTH2	chemoattractant receptor-homologous molecule expressed on Th2 cells	11251	11251	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of PI3K and calcineurin suppresses chemoattractant_receptor-homologous_molecule_expressed_on_Th2_cells -LRB- CRTH2 -RRB- - dependent responses of Th2 lymphocytes to prostaglandin_D -LRB- 2 -RRB- .
25698598	0	CRTH2	0,5	prostaglandin_D2	9,25	CRTH2	prostaglandin D2	14764(Tax:10090)	19215(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	CRTH2 , a prostaglandin_D2 receptor , mediates depression-related behavior in mice .
8661155	0	CRTR	58,62	creatine_transporter	36,56	CRTR	creatine transporter	6535	6535	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The genomic organization of a human creatine_transporter -LRB- CRTR -RRB- gene located in Xq28 .
25517972	0	CRTh2	31,36	DP2	26,29	CRTh2	DP2	11251	11251	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Correction : Expression of DP2 -LRB- CRTh2 -RRB- , a Prostaglandin D2 Receptor , in Human Mast Cells .
19823680	0	CRX	94,97	NR2E3	39,44	CRX	NR2E3	1406	10002	Gene	Gene	affect|nmod|START_ENTITY affect|nsubj|Mutations Mutations|nmod|domain domain|nmod|END_ENTITY	Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX .
20949100	0	CRX	62,65	rod-derived_cone_viability_factor	14,47	CRX	rod-derived cone viability factor	12951(Tax:10090)	234404(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of rod-derived_cone_viability_factor : dual role of CRX in regulating promoter activity and cell-type specificity .
10531061	0	CRY1	26,30	clock	67,72	CRY1	clock	1407	9575	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Light-independent role of CRY1 and CRY2 in the mammalian circadian clock .
18988809	0	CRY2	13,17	CIB1	33,37	CRY2	CIB1	839529(Tax:3702)	829604(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis .
24101505	0	CRY2	12,16	CIB1	83,87	CRY2	CIB1	839529(Tax:3702)	829604(Tax:3702)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|regulation regulation|nmod|END_ENTITY	Arabidopsis CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms .
25855785	0	CRY2	21,25	Clock	10,15	CRY2	Clock	1408	9575	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal_Cancer .
7490092	0	CRYBA2	53,59	beta_A2_crystallin	28,46	CRYBA2	beta A2 crystallin	1412	282203(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the human beta_A2_crystallin gene -LRB- CRYBA2 -RRB- : localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1 .
1424806	0	CRYBA4	45,51	beta_A4-crystallin	20,38	CRYBA4	beta A4-crystallin	1413	1413	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the beta_A4-crystallin gene -LRB- CRYBA4 -RRB- on human chromosome 22 in the region q11 .2 -- > q13 .1 .
22792142	0	CRYBA4	52,58	crystallin_beta_A4	32,50	CRYBA4	crystallin beta A4	1413	1413	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of high_myopia with crystallin_beta_A4 -LRB- CRYBA4 -RRB- gene polymorphisms in the linkage-identified MYP6 locus .
12676897	0	CRYGD	25,30	Gamma-D_crystallin	0,18	CRYGD	Gamma-D crystallin	1421	1421	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gamma-D_crystallin gene -LRB- CRYGD -RRB- mutation causes autosomal_dominant_congenital_cerulean_cataracts .
25553844	0	CS	34,36	Shq1	80,84	CS	Shq1	54205	55164	Gene	Gene	Domain|compound|START_ENTITY Structure|nmod|Domain Structure|nmod|END_ENTITY	Structure and Interactions of the CS Domain of Human H/ACA RNP Assembly Protein Shq1 .
1399705	0	CS	38,40	citrate_synthase	20,36	CS	citrate synthase	397519(Tax:9823)	397519(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the citrate_synthase -LRB- CS -RRB- gene to the p12-p13 bands of chromosome 5 in pigs by in situ hybridization .
598842	0	CS	39,41	citrate_synthase	21,37	CS	citrate synthase	1431	1431	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Direct assignment of citrate_synthase -LRB- CS -RRB- gene to human chromosome 12 in man-mouse somatic cell hybrids .
1976737	0	CS1	60,63	CD4	29,32	CS1	CD4	1442	920	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	VLA-4 mediates CD3-dependent CD4 + T cell activation via the CS1 alternatively spliced domain of fibronectin .
23731618	0	CS1	0,3	SLAM	7,11	CS1	SLAM	57823	6504	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	CS1 , a SLAM family receptor involved in immune regulation , is a therapeutic target in multiple_myeloma .
17216190	0	CSAG2	43,48	Taxol-resistance-associated_gene-3	0,34	CSAG2	Taxol-resistance-associated gene-3	102723547	102723547	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Taxol-resistance-associated_gene-3 -LRB- TRAG-3 / CSAG2 -RRB- expression is predictive for clinical outcome in ovarian_carcinoma patients .
12743424	0	CSAp	19,23	CEA	14,17	CSAp	CEA	1161	1084	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Colonic_tumor CEA , CSAp and MUC-1 expression following radioimmunotherapy or chemotherapy .
8811084	0	CSB	10,13	ERCC6	15,20	CSB	ERCC6	2074	2074	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human CSB -LRB- ERCC6 -RRB- gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61 .
9443879	0	CSB	39,42	ERCC6	44,49	CSB	ERCC6	2074	2074	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of mutations in the CSB -LRB- ERCC6 -RRB- gene in patients with Cockayne_syndrome .
25505141	0	CSB	0,3	SNM1A	19,24	CSB	SNM1A	1443	9937	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CSB interacts with SNM1A and promotes DNA interstrand crosslink processing .
23028371	0	CSB-PGBD3	63,72	AP-1	88,92	CSB-PGBD3	AP-1	101243544	3725	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans .
25973023	0	CSE1L	113,118	CSE1L	46,51	CSE1L	CSE1L	1434	1434	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	High expression of cytoplasmic phosphorylated CSE1L in malignant melanoma but not in benign nevi : phosphorylated CSE1L for the discrimination between melanoma and benign nevi .
25973023	0	CSE1L	46,51	CSE1L	113,118	CSE1L	CSE1L	1434	1434	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	High expression of cytoplasmic phosphorylated CSE1L in malignant melanoma but not in benign nevi : phosphorylated CSE1L for the discrimination between melanoma and benign nevi .
6661467	0	CSF	33,36	Acetylcholinesterase	0,20	CSF	Acetylcholinesterase	1437	43	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Acetylcholinesterase activity in CSF in schizophrenia , depression , Alzheimer 's _ disease and normals .
2956475	0	CSF	25,28	Beta_endorphin	0,14	CSF	Beta endorphin	1437	5443	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Beta_endorphin levels in CSF during methadone maintenance .
16626811	0	CSF	24,27	IL-6	0,4	CSF	IL-6	1437	3569	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	IL-6 and CCL2 levels in CSF are associated with the clinical course of MS : implications for their possible immunopathogenic roles .
22076255	0	CSF	0,3	alpha-synuclein	25,40	CSF	alpha-synuclein	1437	6622	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative_disease .
20828718	0	CSF	79,82	amyloid_precursor_protein	93,118	CSF	amyloid precursor protein	1437	351	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Biochemical studies in Normal Pressure Hydrocephalus -LRB- NPH -RRB- patients : change in CSF levels of amyloid_precursor_protein -LRB- APP -RRB- , amyloid-beta -LRB- Ab -RRB- peptide and phospho-tau .
6332035	0	CSF	98,101	colony-stimulating_factor	71,96	CSF	colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Retroviruses released from a human tumor xenograft in nude_mice induce colony-stimulating_factor -LRB- CSF -RRB- activity in human fibroblastic cells .
310773	0	CSF	16,19	colony_stimulating_factor	21,46	CSF	colony stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of CSF -LRB- colony_stimulating_factor -RRB- in kidney of the mouse .
417824	1	CSF	143,146	colony_stimulating_factor	117,142	CSF	colony stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Comparison with colony_stimulating_factor CSF -RRB- -RSB- .
7653683	0	CSF	13,16	interleukin-2	27,40	CSF	interleukin-2	1437	3558	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Increases in CSF levels of interleukin-2 in schizophrenia : effects of recurrence of psychosis and medication status .
8102512	0	CSF	9,12	interleukin-2	23,36	CSF	interleukin-2	1437	3558	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients .
10822447	0	CSF	10,13	nerve_growth_factor	24,43	CSF	nerve growth factor	1437	4803	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Increased CSF levels of nerve_growth_factor in patients with Alzheimer 's _ disease .
9595992	0	CSF	29,32	neuron-specific_enolase	43,66	CSF	neuron-specific enolase	1437	2026	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Status_epilepticus increases CSF levels of neuron-specific_enolase and alters the blood-brain barrier .
3559479	0	CSF	98,101	phosphohexose_isomerase	67,90	CSF	phosphohexose isomerase	1437	2821	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance and source of raised catalytic activities of phosphohexose_isomerase in the CSF in meningitis .
25005824	0	CSF-1	73,78	CSF-1R	66,72	CSF-1	CSF-1R	1435	1436	Gene	Gene	signaling|compound|START_ENTITY blocked|nsubjpass|signaling promotion|parataxis|blocked promotion|acl|caused caused|nmod|inhibition inhibition|nmod|END_ENTITY	The promotion of breast_cancer_metastasis caused by inhibition of CSF-1R / CSF-1 signaling is blocked by targeting the G-CSF_receptor .
25178319	0	CSF-1	49,54	CSF-1R	55,61	CSF-1	CSF-1R	1435	1436	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	The possible mechanisms of tumor progression via CSF-1 / CSF-1R pathway activation .
26051995	0	CSF-1	0,5	CSF-1R	6,12	CSF-1	CSF-1R	1435	1436	Gene	Gene	START_ENTITY|appos|targeting targeting|nsubj|END_ENTITY	CSF-1 / CSF-1R targeting agents in clinical development for cancer therapy .
10025673	0	CSF-1	0,5	CSF-1_receptor	44,58	CSF-1	CSF-1 receptor	1435	1436	Gene	Gene	START_ENTITY|acl|stimulated stimulated|dobj|multiubiquitination multiubiquitination|nmod|END_ENTITY	CSF-1 stimulated multiubiquitination of the CSF-1_receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins .
10942243	0	CSF-1	64,69	CSF-1_receptor	149,163	CSF-1	CSF-1 receptor	1435	1436	Gene	Gene	colony-stimulating_factor-1|appos|START_ENTITY Role|nmod|colony-stimulating_factor-1 Role|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Role of the membrane form of human colony-stimulating_factor-1 -LRB- CSF-1 -RRB- in proliferation of multipotent hematopoietic FDCP-mix cells expressing human CSF-1_receptor .
1532099	0	CSF-1	241,246	CSF-1_receptor	133,147	CSF-1	CSF-1 receptor	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
1532099	0	CSF-1	241,246	CSF-1_receptor	72,86	CSF-1	CSF-1 receptor	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY that|acl|induced induces|nmod|that induces|nsubj|Transduction Transduction|nmod|signal signal|nmod|metabolism metabolism|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
17967422	0	CSF-1	0,5	CSF-1_receptor	124,138	CSF-1	CSF-1 receptor	1435	1436	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|pathways pathways|acl|leading leading|nmod|degradation degradation|nmod|END_ENTITY	CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1_receptor .
1825054	0	CSF-1	109,114	CSF-1_receptor	45,59	CSF-1	CSF-1 receptor	1435	1436	Gene	Gene	response|compound|START_ENTITY Role|nmod|response Role|nmod|END_ENTITY	Role of dimerization and modification of the CSF-1_receptor in its activation and internalization during the CSF-1 response .
1837725	0	CSF-1	105,110	CSF-1_receptor	15,29	CSF-1	CSF-1 receptor	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	dependent|amod|START_ENTITY line|amod|dependent mutants|nmod|line tyrosine|nmod|mutants tyrosine|nsubj|Alterations Alterations|nmod|expression expression|compound|END_ENTITY	Alterations in CSF-1_receptor expression and protein tyrosine phosphorylation in autonomous mutants of a CSF-1 dependent macrophage cell line .
2160591	0	CSF-1	94,99	CSF-1_receptor	144,158	CSF-1	CSF-1 receptor	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	colony-stimulating_factor_1|appos|START_ENTITY insert|nmod|colony-stimulating_factor_1 Identification|nmod|insert Identification|dep|site site|nmod|END_ENTITY	Identification of tyrosine 706 in the kinase insert as the major colony-stimulating_factor_1 -LRB- CSF-1 -RRB- - stimulated autophosphorylation site in the CSF-1_receptor in a murine macrophage cell line .
2826201	0	CSF-1	20,25	CSF-1_receptor	60,74	CSF-1	CSF-1 receptor	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|c-fms c-fms|appos|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
2962881	0	CSF-1	20,25	CSF-1_receptor	60,74	CSF-1	CSF-1 receptor	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|c-fms c-fms|appos|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
9178909	0	CSF-1	0,5	CSF-1_receptor	76,90	CSF-1	CSF-1 receptor	1435	1436	Gene	Gene	stimulation|compound|START_ENTITY induces|nsubj|stimulation induces|dobj|formation formation|nmod|complex complex|nmod|END_ENTITY	CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1_receptor , c-Cbl , PI 3-kinase , Crk-II and Grb2 .
9850165	0	CSF-1	0,5	GM-CSF	82,88	CSF-1	GM-CSF	12977(Tax:10090)	12981(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	CSF-1 regulation of Il6 gene expression by murine macrophages : a pivotal role for GM-CSF .
9850165	0	CSF-1	0,5	Il6	20,23	CSF-1	Il6	12977(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	CSF-1 regulation of Il6 gene expression by murine macrophages : a pivotal role for GM-CSF .
18619508	0	CSF-1	28,33	L-selectin	0,10	CSF-1	L-selectin	1435	6402	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	L-selectin ligation-induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase-dependent manner .
3105621	0	CSF-1	25,30	M-CSF	18,23	CSF-1	M-CSF	1435	1435	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the M-CSF -LRB- CSF-1 -RRB- gene by human monocytes .
16477024	0	CSF-1	84,89	Protein_tyrosine_phosphatase_1B	0,31	CSF-1	Protein tyrosine phosphatase 1B	1435	5770	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|nsubj|END_ENTITY	Protein_tyrosine_phosphatase_1B negatively regulates macrophage development through CSF-1 signaling .
8336080	0	CSF-1	115,120	TNF-alpha	155,164	CSF-1	TNF-alpha	12977(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Analysis of the synergistic stimulation of mouse macrophage proliferation by macrophage colony-stimulating factor -LRB- CSF-1 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- .
14696961	0	CSF-1	44,49	TRAP	146,150	CSF-1	TRAP	78965(Tax:10116)	25732(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- on the development of osteoclasts and their expression of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- in toothless -LRB- tl-osteopetrotic -RRB- rats .
9521506	0	CSF-1	53,58	biglycan	14,22	CSF-1	biglycan	1435	633	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of biglycan , decorin and proteoglycan-100 / CSF-1 in normal and fibrotic human liver .
1374350	0	CSF-1	14,19	c-fms	20,25	CSF-1	c-fms	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|mRNA mRNA|amod|END_ENTITY	Expression of CSF-1 / c-fms and SF/c-kit mRNA during preimplantation mouse development .
2826201	0	CSF-1	20,25	c-fms	76,81	CSF-1	c-fms	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
2962881	0	CSF-1	20,25	c-fms	76,81	CSF-1	c-fms	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
9541255	0	CSF-1	10,15	c-fos	41,46	CSF-1	c-fos	78965(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of CSF-1 on in vivo expression of c-fos in the dental follicle during tooth eruption .
1352526	0	CSF-1	137,142	colony-stimulating_factor	110,135	CSF-1	colony-stimulating factor	1435	1435	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Contributions of the CD2 and CD28 T lymphocyte activation pathways to the regulation of the expression of the colony-stimulating_factor -LRB- CSF-1 -RRB- gene .
3485107	0	CSF-1	52,57	colony-stimulating_factor	25,50	CSF-1	colony-stimulating factor	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Persistent production of colony-stimulating_factor -LRB- CSF-1 -RRB- by cloned bone marrow stromal cell line D2XRII after X-irradiation .
6094601	0	CSF-1	76,81	colony-stimulating_factor	49,74	CSF-1	colony-stimulating factor	12977(Tax:10090)	12981(Tax:10090)	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Receptor-mediated binding and internalization of colony-stimulating_factor -LRB- CSF-1 -RRB- by mouse peritoneal exudate macrophages .
15867372	0	CSF-1	117,122	colony-stimulating_factor-1	88,115	CSF-1	colony-stimulating factor-1	1435	1435	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase binds to the AU-Rich 3 ' untranslated region of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- messenger RNA in human ovarian_cancer cells : possible role in CSF-1 posttranscriptional regulation and tumor phenotype .
1791839	0	CSF-1	43,48	colony-stimulating_factor-1	14,41	CSF-1	colony-stimulating factor-1	1435	1435	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Expression of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- messenger RNA in human endometrial glands during the menstrual cycle : molecular cloning of a novel transcript that predicts a cell surface form of CSF-1 .
2151455	0	CSF-1	43,48	colony-stimulating_factor-1	14,41	CSF-1	colony-stimulating factor-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- by mouse astroglia in vitro .
22096574	0	CSF-1	33,38	colony-stimulating_factor-1	4,31	CSF-1	colony-stimulating factor-1	1435	1435	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The colony-stimulating_factor-1 -LRB- CSF-1 -RRB- receptor sustains ERK1/2 activation and proliferation in breast_cancer cell lines .
9116300	0	CSF-1	180,185	colony-stimulating_factor-1	22,49	CSF-1	colony-stimulating factor-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Increased circulating colony-stimulating_factor-1 -LRB- CSF-1 -RRB- in SJL/J mice with radiation-induced acute_myeloid_leukemia -LRB- AML -RRB- is associated with autocrine regulation of AML cells by CSF-1 .
1691932	0	CSF-1	35,40	colony-stimulating_factor_1	6,33	CSF-1	colony-stimulating factor 1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Human colony-stimulating_factor_1 -LRB- CSF-1 -RRB- receptor confers CSF-1 responsiveness to interleukin-3-dependent 32DC13 mouse myeloid cells and abrogates differentiation in response to granulocyte CSF .
8554432	0	CSF-1	48,53	colony_stimulating_factor-1	19,46	CSF-1	colony stimulating factor-1	1435	1435	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Enhanced levels of colony_stimulating_factor-1 -LRB- CSF-1 -RRB- in sera and seminal plasma of antisperm antibody-positive infertile men .
9039846	0	CSF-1	61,66	colony_stimulating_factor-1	32,59	CSF-1	colony stimulating factor-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Myoblast-mediated expression of colony_stimulating_factor-1 -LRB- CSF-1 -RRB- in the cytokine-deficient op/op mouse .
15812575	0	CSF-1	0,5	fos	14,17	CSF-1	fos	12977(Tax:10090)	14281(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	CSF-1 induces fos gene transcription and activates the transcription factor Elk-1 in mature osteoclasts .
25005824	0	CSF-1R	66,72	CSF-1	73,78	CSF-1R	CSF-1	1436	1435	Gene	Gene	inhibition|nmod|START_ENTITY caused|nmod|inhibition promotion|acl|caused promotion|parataxis|blocked blocked|nsubjpass|signaling signaling|compound|END_ENTITY	The promotion of breast_cancer_metastasis caused by inhibition of CSF-1R / CSF-1 signaling is blocked by targeting the G-CSF_receptor .
25178319	0	CSF-1R	55,61	CSF-1	49,54	CSF-1R	CSF-1	1436	1435	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	The possible mechanisms of tumor progression via CSF-1 / CSF-1R pathway activation .
26051995	0	CSF-1R	6,12	CSF-1	0,5	CSF-1R	CSF-1	1436	1435	Gene	Gene	targeting|nsubj|START_ENTITY END_ENTITY|appos|targeting	CSF-1 / CSF-1R targeting agents in clinical development for cancer therapy .
10025673	0	CSF-1_receptor	44,58	CSF-1	0,5	CSF-1 receptor	CSF-1	1436	1435	Gene	Gene	multiubiquitination|nmod|START_ENTITY stimulated|dobj|multiubiquitination END_ENTITY|acl|stimulated	CSF-1 stimulated multiubiquitination of the CSF-1_receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins .
10942243	0	CSF-1_receptor	149,163	CSF-1	64,69	CSF-1 receptor	CSF-1	1436	1435	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing Role|nmod|cells Role|nmod|colony-stimulating_factor-1 colony-stimulating_factor-1|appos|END_ENTITY	Role of the membrane form of human colony-stimulating_factor-1 -LRB- CSF-1 -RRB- in proliferation of multipotent hematopoietic FDCP-mix cells expressing human CSF-1_receptor .
1532099	0	CSF-1_receptor	133,147	CSF-1	241,246	CSF-1 receptor	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
1532099	0	CSF-1_receptor	72,86	CSF-1	241,246	CSF-1 receptor	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	metabolism|nmod|START_ENTITY signal|nmod|metabolism Transduction|nmod|signal induces|nsubj|Transduction induces|nmod|that that|acl|induced induced|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
17967422	0	CSF-1_receptor	124,138	CSF-1	0,5	CSF-1 receptor	CSF-1	1436	1435	Gene	Gene	degradation|nmod|START_ENTITY leading|nmod|degradation pathways|acl|leading stimulate|dobj|pathways stimulate|nsubj|END_ENTITY	CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1_receptor .
1825054	0	CSF-1_receptor	45,59	CSF-1	109,114	CSF-1 receptor	CSF-1	1436	1435	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|response response|compound|END_ENTITY	Role of dimerization and modification of the CSF-1_receptor in its activation and internalization during the CSF-1 response .
1837725	0	CSF-1_receptor	15,29	CSF-1	105,110	CSF-1 receptor	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Alterations|nmod|expression tyrosine|nsubj|Alterations tyrosine|nmod|mutants mutants|nmod|line line|amod|dependent dependent|amod|END_ENTITY	Alterations in CSF-1_receptor expression and protein tyrosine phosphorylation in autonomous mutants of a CSF-1 dependent macrophage cell line .
2160591	0	CSF-1_receptor	144,158	CSF-1	94,99	CSF-1 receptor	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	site|nmod|START_ENTITY Identification|dep|site Identification|nmod|insert insert|nmod|colony-stimulating_factor_1 colony-stimulating_factor_1|appos|END_ENTITY	Identification of tyrosine 706 in the kinase insert as the major colony-stimulating_factor_1 -LRB- CSF-1 -RRB- - stimulated autophosphorylation site in the CSF-1_receptor in a murine macrophage cell line .
2826201	0	CSF-1_receptor	60,74	CSF-1	20,25	CSF-1 receptor	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	c-fms|appos|START_ENTITY responsiveness|nmod|c-fms responsiveness|compound|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
2962881	0	CSF-1_receptor	60,74	CSF-1	20,25	CSF-1 receptor	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	c-fms|appos|START_ENTITY responsiveness|nmod|c-fms responsiveness|compound|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
9178909	0	CSF-1_receptor	76,90	CSF-1	0,5	CSF-1 receptor	CSF-1	1436	1435	Gene	Gene	complex|nmod|START_ENTITY formation|nmod|complex induces|dobj|formation induces|nsubj|stimulation stimulation|compound|END_ENTITY	CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1_receptor , c-Cbl , PI 3-kinase , Crk-II and Grb2 .
1532099	0	CSF-1_receptor	133,147	CSF-1_receptor	72,86	CSF-1 receptor	CSF-1 receptor	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY that|acl|induced induces|nmod|that induces|nsubj|Transduction Transduction|nmod|signal signal|nmod|metabolism metabolism|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
1532099	0	CSF-1_receptor	72,86	CSF-1_receptor	133,147	CSF-1 receptor	CSF-1 receptor	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	metabolism|nmod|START_ENTITY signal|nmod|metabolism Transduction|nmod|signal induces|nsubj|Transduction induces|nmod|that that|acl|induced induced|nmod|END_ENTITY	Transduction of a signal for arachidonic_acid metabolism by untriggered CSF-1_receptor induces an opposite effect to that induced by CSF-1_receptor and its ligand : separate regulation of phospholipase A2 and cyclooxygenase by CSF-1_receptor / CSF-1 .
9000134	0	CSF-1_receptor	58,72	STAT1	77,82	CSF-1 receptor	STAT1	1436	6772	Gene	Gene	START_ENTITY|nmod|activation activation|nummod|END_ENTITY	Requirement for Y706 of the murine -LRB- or Y708 of the human -RRB- CSF-1_receptor for STAT1 activation in response to CSF-1 .
18453593	0	CSF-1_receptor	115,129	csf1r	131,136	CSF-1 receptor	csf1r	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Ewing_sarcoma protein -LRB- EWS -RRB- binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1_receptor -LRB- csf1r -RRB- gene .
24019961	0	CSF1	0,4	p53	16,19	CSF1	p53	1435	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest .
22729249	0	CSF1R	39,44	IL-34	0,5	CSF1R	IL-34	12978(Tax:10090)	76527(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia .
22197934	0	CSF1R	55,60	colony_stimulating_factor_1_receptor	17,53	CSF1R	colony stimulating factor 1 receptor	1436	1436	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the colony_stimulating_factor_1_receptor -LRB- CSF1R -RRB- gene cause hereditary diffuse_leukoencephalopathy with spheroids .
11289721	0	CSF2	80,84	colony-stimulating_factor_2	51,78	CSF2	colony-stimulating factor 2	1437	1437	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel single nucleotide polymorphisms of the human colony-stimulating_factor_2 -LRB- CSF2 -RRB- gene identified by sequencing the entire gene .
24403076	0	CSF3R	87,92	colony-stimulating_factor_3_receptor	49,85	CSF3R	colony-stimulating factor 3 receptor	1441	1441	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Ligand independence of the T618I mutation in the colony-stimulating_factor_3_receptor -LRB- CSF3R -RRB- protein results from loss_of_O-linked_glycosylation and increased receptor dimerization .
12746317	0	CSK	23,26	Src	85,88	CSK	Src	12988(Tax:10090)	20779(Tax:10090)	Gene	Gene	C-terminal_Src_kinase|appos|START_ENTITY modulates|nsubj|C-terminal_Src_kinase modulates|dobj|factor-I factor-I|acl|signaling signaling|nmod|END_ENTITY	C-terminal_Src_kinase -LRB- CSK -RRB- modulates insulin-like growth factor-I signaling through Src in 3T3-L1 differentiation .
24632723	0	CSK	83,86	Src	40,43	CSK	Src	1445	6714	Gene	Gene	inhibition|nmod|START_ENTITY activity|nmod|inhibition activity|compound|END_ENTITY	SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes .
7678701	0	CSK	109,112	Src	19,22	CSK	Src	315707(Tax:10116)	83805(Tax:10116)	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|Phosphorylation Phosphorylation|nmod|mutants mutants|compound|END_ENTITY	Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK .
9172452	0	CSK	0,3	TCR	100,103	CSK	TCR	1445	6962	Gene	Gene	associates|compound|START_ENTITY associates|dep|mechanism mechanism|acl|turning turning|dobj|signaling signaling|compound|END_ENTITY	CSK associates with the TCR zeta and epsilon chains via its SH2 domain ; a mechanism for turning off TCR signaling .
9172452	0	CSK	0,3	TCR	24,27	CSK	TCR	1445	6962	Gene	Gene	associates|compound|START_ENTITY associates|nmod|zeta zeta|compound|END_ENTITY	CSK associates with the TCR zeta and epsilon chains via its SH2 domain ; a mechanism for turning off TCR signaling .
1377109	0	CSK	27,30	c-src_tyrosine_kinase	4,25	CSK	c-src tyrosine kinase	1445	1445	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The c-src_tyrosine_kinase -LRB- CSK -RRB- gene , a potential antioncogene , localizes to human chromosome region 15q23 -- q25 .
26437743	0	CSL	0,3	AKT	14,17	CSL	AKT	1444	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	CSL regulates AKT to mediate androgen independence in prostate_cancer progression .
12223465	0	CSL	89,92	Notch	59,64	CSL	Notch	34881(Tax:7227)	31293(Tax:7227)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Keeping a good pathway down : transcriptional repression of Notch pathway target genes by CSL proteins .
18768911	0	CSLD1	57,62	CSLD2	64,69	CSLD1	CSLD2	817872(Tax:3702)	831554(Tax:3702)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Functional analysis of the cellulose synthase-like genes CSLD1 , CSLD2 , and CSLD4 in tip-growing Arabidopsis cells .
18768911	0	CSLD2	64,69	CSLD1	57,62	CSLD2	CSLD1	831554(Tax:3702)	817872(Tax:3702)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Functional analysis of the cellulose synthase-like genes CSLD1 , CSLD2 , and CSLD4 in tip-growing Arabidopsis cells .
23505554	0	CSMD1	93,98	Cub_and_Sushi_Multiple_Domains_1	59,91	CSMD1	Cub and Sushi Multiple Domains 1	64478	64478	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Somatic mutations , allele loss , and DNA methylation of the Cub_and_Sushi_Multiple_Domains_1 -LRB- CSMD1 -RRB- gene reveals association with early age of diagnosis in colorectal_cancer patients .
11854419	0	CSN1	154,158	COP9	170,174	CSN1	COP9	825286(Tax:3702)	827049(Tax:3702)	Gene	Gene	subunit|nummod|START_ENTITY subunit|nmod|END_ENTITY	CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins : a structure-function study of CSN1 subunit of COP9 signalosome .
11418127	0	CSN3	0,4	TNF	42,45	CSN3	TNF	1448	7124	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CSN3 interacts with IKKgamma and inhibits TNF - but not IL-1-induced NF-kappaB activation .
18752583	0	CSN3	35,39	casein	27,33	CSN3	casein	100033983(Tax:9796)	100033983(Tax:9796)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the kappa casein -LRB- CSN3 -RRB- gene in horse and comparative analysis of its promoter and coding region .
11086538	0	CSN3	111,115	k-casein	101,109	CSN3	k-casein	281728(Tax:9913)	281728(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms -LRB- SNPs -RRB- within Bov-A2 SINE in the second intron of bovine and buffalo k-casein -LRB- CSN3 -RRB- gene .
25091943	0	CSN3	31,35	k-casein	37,45	CSN3	k-casein	281728(Tax:9913)	281728(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effect of polymorphisms in the CSN3 -LRB- k-casein -RRB- gene on milk production traits in Chinese Holstein Cattle .
15190947	0	CSN3	39,43	kappa-casein	25,37	CSN3	kappa-casein	100861231	100861231	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High polymorphism in the kappa-casein -LRB- CSN3 -RRB- gene from wild and domestic caprine species revealed by DNA sequencing .
17333943	0	CSN3	44,48	kappa-casein	25,37	CSN3	kappa-casein	281728(Tax:9913)	281728(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Allelic polymorphism of kappa-casein gene -LRB- CSN3 -RRB- in Russian cattle breeds and its informative value as a genetic marker -RSB- .
23316279	0	CSN5	0,4	CDK2	33,37	CSN5	CDK2	10987	1017	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CSN5 specifically interacts with CDK2 and controls senescence in a cytoplasmic cyclin E-mediated manner .
23424245	0	CSN5B	12,17	VTC1	33,37	CSN5B	VTC1	843463(Tax:3702)	818562(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic_acid synthesis .
26237449	0	CSN6	0,4	c-Jun	26,31	CSN6	c-Jun	10980	3725	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	CSN6 positively regulates c-Jun in a MEKK1-dependent manner .
25802485	0	CSNB1	64,69	NYX	0,3	CSNB1	NYX	60506	60506	Gene	Gene	mutations|nmod|START_ENTITY mutations|nsubj|END_ENTITY	NYX mutations in four families with high_myopia with or without CSNB1 .
9418727	0	CSNB4	23,28	RP2	68,71	CSNB4	RP2	60506	6102	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of CSNBX -LRB- CSNB4 -RRB- between the retinitis_pigmentosa loci RP2 and RP3 on proximal Xp .
20671611	0	CSNK1A1	26,33	NME1	54,58	CSNK1A1	NME1	1452	4830	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nsubj|levels	Gene expression levels of CSNK1A1 and AAC-11 , but not NME1 , in tumor tissues as prognostic factors in NSCLC patients .
16954406	0	CSP-1	96,101	Dcpp	102,106	CSP-1	Dcpp	1827	13184(Tax:10090)	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Identification of a human ortholog of the mouse Dcpp gene locus , encoding a novel member of the CSP-1 / Dcpp salivary protein family .
2788607	0	CSPB	76,80	serine_protease	54,69	CSPB	serine protease	3002	2147	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and chromosomal assignment for a serine_protease gene -LRB- CSPB -RRB- expressed by human cytotoxic lymphocytes .
18484070	0	CSPG2	36,41	Chondroitin_sulfate_proteoglycan_2	0,34	CSPG2	Chondroitin sulfate proteoglycan 2	1462	1462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chondroitin_sulfate_proteoglycan_2 -LRB- CSPG2 -RRB- gene polymorphisms rs173686 and rs251124 are not associated with intracranial_aneurysms in Chinese Han nationality .
9795216	0	CSPG3	45,50	neurocan	30,38	CSPG3	neurocan	1463	1463	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the human neurocan gene , CSPG3 .
26492373	0	CSRP3	25,30	Muscle_Lim_Protein	0,18	CSRP3	Muscle Lim Protein	8048	8048	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Muscle_Lim_Protein -LRB- MLP -RRB- / CSRP3 at the crossroad between mechanotransduction and autophagy .
20231363	0	CST	49,52	Gal3st1	40,47	CST	Gal3st1	53897(Tax:10090)	53897(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of a testis-specific form of Gal3st1 -LRB- CST -RRB- , a gene essential for spermatogenesis , is regulated by the CTCF paralogous gene BORIS .
20157249	0	CST3	4,8	cystatin_C	29,39	CST3	cystatin C	1471	1471	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	The CST3 BB genotype and low cystatin_C cerebrospinal fluid levels are associated with dementia in Lewy_body_disease .
22435454	0	CST3	32,36	cystatin_C	21,31	CST3	cystatin C	1471	1471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Meta-analysis of the cystatin_C -LRB- CST3 -RRB- gene G73A polymorphism and susceptibility to Alzheimer 's _ disease .
2567273	0	CST3	27,31	cystatin_C	10,20	CST3	cystatin C	1471	1471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human cystatin_C gene -LRB- CST3 -RRB- , mutated in hereditary cystatin_C amyloid_angiopathy , is located on chromosome 20 .
2764935	0	CST3	27,31	cystatin_C	10,20	CST3	cystatin C	1471	1471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human cystatin_C gene -LRB- CST3 -RRB- is a member of the cystatin gene family which is localized on chromosome 20 .
8103758	0	CST3	72,76	cystatin_C	55,65	CST3	cystatin C	1471	1471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An Ala/Thr variation in the coding region of the human cystatin_C gene -LRB- CST3 -RRB- detected as a SstII polymorphism .
8422752	0	CST5	43,47	cystatin_D	26,36	CST5	cystatin D	1473	1473	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human cystatin_D gene -LRB- CST5 -RRB- to chromosome 20p11 .21 by in situ hybridization .
26158294	0	CST5	34,38	p53	0,3	CST5	p53	1473	7157	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	p53 directly activates cystatin_D / CST5 to mediate mesenchymal-epithelial_transition : a possible link to tumor suppression by vitamin_D .
9612365	0	CSX	50,53	Nkx2-5	42,48	CSX	Nkx2-5	18091(Tax:10090)	18091(Tax:10090)	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of the cardiac homeobox gene Nkx2-5 -LRB- CSX -RRB- in feline right ventricular pressure overload .
21577144	0	CT-011	17,23	PD-1	0,4	CT-011	PD-1	884048(Tax:272561)	100037293(Tax:9823)	Gene	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	PD-1 blockade by CT-011 , anti-PD-1 antibody , enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine .
23836438	0	CT-1	66,70	CDX2	0,4	CT-1	CDX2	282367(Tax:9913)	618679(Tax:9913)	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	CDX2 regulates multiple trophoblast genes in bovine trophectoderm CT-1 cells .
9038192	0	CT-1	17,21	Cardiotrophin_1	0,15	CT-1	Cardiotrophin 1	1489	1489	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Cardiotrophin_1 -LRB- CT-1 -RRB- inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway .
11360260	0	CT-1	28,32	cardiotrophin-1	11,26	CT-1	cardiotrophin-1	13019(Tax:10090)	13019(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of cardiotrophin-1 -LRB- CT-1 -RRB- in a mouse motor_neuron_disease .
14597603	0	CT-1	43,47	cardiotrophin-1	26,41	CT-1	cardiotrophin-1	1489	1489	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and effects of cardiotrophin-1 -LRB- CT-1 -RRB- in human airway smooth muscle cells .
14555790	0	CT-1	59,63	urocortin	27,36	CT-1	urocortin	1489	7349	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The cardioprotective agent urocortin induces expression of CT-1 .
12807879	0	CT10_regulator_of_kinase	44,68	Crk	70,73	CT10 regulator of kinase	Crk	1398	1398	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Pseudomonas_aeruginosa ExoT ADP-ribosylates CT10_regulator_of_kinase -LRB- Crk -RRB- proteins .
17130562	0	CT60	25,29	CTLA-4	13,19	CT60	CTLA-4	348120	1493	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin_D_receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related_type_1_diabetes in the Japanese .
24697361	0	CT60	7,11	CTLA-4	0,6	CT60	CTLA-4	348120	1493	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	CTLA-4 CT60 -LRB- rs3087243 -RRB- polymorphism and autoimmune thyroid_diseases susceptibility : a comprehensive meta-analysis .
18780601	0	CT60	15,19	CTLA4	40,45	CT60	CTLA4	348120	1493	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Association of CT60 polymorphism of the CTLA4 gene with Graves ' _ disease in Taiwanese children .
17532760	0	CT847	26,31	GCIP	6,10	CT847	GCIP	884648(Tax:272561)	23582	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human GCIP interacts with CT847 , a novel Chlamydia_trachomatis type III secretion substrate , and is degraded in a tissue-culture infection model .
25944661	0	CT850	49,54	DYNLT1	93,99	CT850	DYNLT1	884650(Tax:272561)	6993	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Chlamydia_trachomatis inclusion membrane protein CT850 interacts with the dynein light chain DYNLT1 -LRB- Tctex1 -RRB- .
10704737	0	CT9	125,128	bromodomain_testis-specific_gene	67,99	CT9	bromodomain testis-specific gene	676	676	Gene	Gene	gene|appos|START_ENTITY END_ENTITY|nmod|gene	Expression of cancer-testis antigens in lung_cancer : definition of bromodomain_testis-specific_gene -LRB- BRDT -RRB- as a new CT gene , CT9 .
15115514	0	CTACK	55,60	cutaneous_T-cell_attracting_chemokine	16,53	CTACK	cutaneous T-cell attracting chemokine	10850	10850	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of cutaneous_T-cell_attracting_chemokine -LRB- CTACK -RRB- as a laboratory marker of the severity of atopic_dermatitis in children .
20663531	0	CTB	113,116	gp120	94,99	CTB	gp120	9468	3700	Gene	Gene	loop|nmod|START_ENTITY loop|amod|END_ENTITY	Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold .
9479502	0	CTBP1	65,70	C-terminal_binding_protein	8,34	CTBP1	C-terminal binding protein	1487	1488	Gene	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	A novel C-terminal_binding_protein -LRB- CTBP2 -RRB- is closely related to CTBP1 , an adenovirus E1A-binding protein , and maps to human chromosome 21q21 .3 .
22357613	0	CTC1	20,24	ATR	0,3	CTC1	ATR	826554(Tax:3702)	834082(Tax:3702)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis .
24362533	0	CTCF	6,10	BCL6	42,46	CTCF	BCL6	10664	604	Gene	Gene	binding|compound|START_ENTITY binding|nmod|site site|nmod|exon1A exon1A|nmod|END_ENTITY	Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus .
26682243	0	CTCF	25,29	BCL6	40,44	CTCF	BCL6	10664	604	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The epigenetic regulator CTCF modulates BCL6 in lymphoma .
12191639	0	CTCF	18,22	BORIS	10,15	CTCF	BORIS	10664	140690	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer .
25368383	0	CTCF	20,24	Bithorax_Complex	82,98	CTCF	Bithorax Complex	38817(Tax:7227)	42034(Tax:7227)	Gene	Gene	Site|compound|START_ENTITY Site|nmod|END_ENTITY	A Variably Occupied CTCF Binding Site in the Ultrabithorax Gene in the Drosophila Bithorax_Complex .
25297545	0	CTCF	34,38	CCCTC-Binding_Factor	12,32	CTCF	CCCTC-Binding Factor	10664	10664	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of CCCTC-Binding_Factor -LRB- CTCF -RRB- in Genomic Imprinting , Development , and Reproduction .
17583694	0	CTCF	41,45	CCCTC_binding_factor	19,39	CTCF	CCCTC binding factor	10664	10664	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Functional role of CCCTC_binding_factor -LRB- CTCF -RRB- in stress-induced apoptosis .
23843455	0	CTCF	137,141	CCCTC_binding_factor	115,135	CTCF	CCCTC binding factor	10664	10664	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- - induced corneal_epithelial wound healing through nuclear factor kB subtype-regulated CCCTC_binding_factor -LRB- CTCF -RRB- activation .
26321640	0	CTCF	0,4	CENP-E	34,40	CTCF	CENP-E	10664	1062	Gene	Gene	Protein|compound|START_ENTITY END_ENTITY|nsubj|Protein	CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites .
22709888	0	CTCF	71,75	CTCFL	34,39	CTCF	CTCFL	13018(Tax:10090)	664799(Tax:10090)	Gene	Gene	different|nmod|START_ENTITY different|nsubj|END_ENTITY	The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner .
23874213	0	CTCF	8,12	FMR1	35,39	CTCF	FMR1	10664	2332	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Role of CTCF protein in regulating FMR1 locus transcription .
26478432	0	CTCF	0,4	HOXA10	26,32	CTCF	HOXA10	10664	3206	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	CTCF negatively regulates HOXA10 expression in breast_cancer cells .
22754359	0	CTCF	52,56	HUWE1	28,33	CTCF	HUWE1	10664	10075	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|compound|END_ENTITY	Characterization of ARF-BP1 / HUWE1 Interactions with CTCF , MYC , ARF and p53 in MYC-Driven B Cell Neoplasms .
12960026	0	CTCF	0,4	IGF2	51,55	CTCF	IGF2	10664	3481	Gene	Gene	binding|compound|START_ENTITY binding|nmod|insulin-like_growth_factor-II insulin-like_growth_factor-II|appos|END_ENTITY	CTCF binding at the insulin-like_growth_factor-II -LRB- IGF2 -RRB- / H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues .
15060168	0	CTCF	21,25	Igf2	96,100	CTCF	Igf2	10664	3481	Gene	Gene	site|compound|START_ENTITY Mutation|nmod|site leads|nsubj|Mutation leads|nmod|loss loss|nmod|patterns patterns|amod|END_ENTITY	Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance .
16815976	0	CTCF	0,4	Igf2	147,151	CTCF	Igf2	10664	3481	Gene	Gene	mediates|nummod|START_ENTITY inherited|nsubj|mediates inherited|advcl|restrict restrict|nmod|END_ENTITY	CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2 .
18662993	0	CTCF	0,4	Igf2	37,41	CTCF	Igf2	13018(Tax:10090)	16002(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb_repressive_complex_2_intrachromosomal_loop .
21689595	0	CTCF	0,4	ataxin-7	15,23	CTCF	ataxin-7	13018(Tax:10090)	246103(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	CTCF regulates ataxin-7 expression through promotion of a convergently transcribed , antisense noncoding RNA .
12960026	0	CTCF	0,4	insulin-like_growth_factor-II	20,49	CTCF	insulin-like growth factor-II	10664	3481	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	CTCF binding at the insulin-like_growth_factor-II -LRB- IGF2 -RRB- / H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues .
22168535	0	CTCFL	43,48	BORIS	36,41	CTCFL	BORIS	140690	140690	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the epigenetic factor BORIS -LRB- CTCFL -RRB- in the human genome .
22709888	0	CTCFL	34,39	CTCF	71,75	CTCFL	CTCF	664799(Tax:10090)	13018(Tax:10090)	Gene	Gene	different|nsubj|START_ENTITY different|nmod|END_ENTITY	The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner .
10327073	0	CTF1	21,25	HOX11	0,5	CTF1	HOX11	1489	3204	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization .
2265610	0	CTF_1	11,16	CHL_1	4,9	CTF 1	CHL 1	856099(Tax:4932)	856099(Tax:4932)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	The CHL_1 -LRB- CTF_1 -RRB- gene product of Saccharomyces_cerevisiae is important for chromosome transmission and normal cell cycle progression in G2/M .
22749815	0	CTGF	25,29	Angiotensin_II	0,14	CTGF	Angiotensin II	1490	183	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases CTGF expression via MAPKs/TGF-b 1/TRAF6 pathway in atrial fibroblasts .
18632843	0	CTGF	0,4	BMP-7	14,19	CTGF	BMP-7	14219(Tax:10090)	12162(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	CTGF inhibits BMP-7 signaling in diabetic_nephropathy .
22099397	0	CTGF	119,123	BMP-7	0,5	CTGF	BMP-7	1490	655	Gene	Gene	expression|amod|START_ENTITY blockage|nmod|expression involved|nmod|blockage components|acl|involved myoblasts|dep|components signalling|nmod|myoblasts END_ENTITY|appos|signalling	BMP-7 / TGF-b1 signalling in myoblasts : components involved in signalling and BMP-7-dependent blockage of TGF-b-mediated CTGF expression .
23207149	0	CTGF	39,43	CTGF	77,81	CTGF	CTGF	64032(Tax:10116)	64032(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of shRNA-mediated silencing of CTGF and TIMP-1 on mRNA expression of CTGF , TIMP-1 , and PC I and secretion of extracellular matrix in rat hepatic stellate cells -RSB- .
23207149	0	CTGF	77,81	CTGF	39,43	CTGF	CTGF	64032(Tax:10116)	64032(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of shRNA-mediated silencing of CTGF and TIMP-1 on mRNA expression of CTGF , TIMP-1 , and PC I and secretion of extracellular matrix in rat hepatic stellate cells -RSB- .
22169285	0	CTGF	22,26	CYR61	15,20	CTGF	CYR61	1490	3491	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
26425899	0	CTGF	57,61	Connective_Tissue_Growth_Factor	24,55	CTGF	Connective Tissue Growth Factor	1490	1490	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Increased Expression of Connective_Tissue_Growth_Factor -LRB- CTGF -RRB- in Multiple Organs After Exposure of Non-Human Primates -LRB- NHP -RRB- to Lethal Doses of Radiation .
26599235	0	CTGF	47,51	Connective_Tissue_Growth_Factor	14,45	CTGF	Connective Tissue Growth Factor	1490	1490	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Alteration of Connective_Tissue_Growth_Factor -LRB- CTGF -RRB- Expression in Orbital Fibroblasts from Patients with Graves ' _ Ophthalmopathy .
15319369	0	CTGF	33,37	Connective_tissue_growth_factor	0,31	CTGF	Connective tissue growth factor	1490	1490	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Connective_tissue_growth_factor -LSB- CTGF -RSB- / CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization .
16186174	0	CTGF	33,37	Connective_tissue_growth_factor	0,31	CTGF	Connective tissue growth factor	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Connective_tissue_growth_factor -LRB- CTGF -RRB- expression in the brain is a downstream effector of insulin resistance - associated promotion of Alzheimer 's _ disease beta-amyloid_neuropathology .
19955828	0	CTGF	33,37	Connective_tissue_growth_factor	0,31	CTGF	Connective tissue growth factor	1490	1490	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Connective_tissue_growth_factor - -LRB- CTGF , CCN2 -RRB- -- a marker , mediator and therapeutic target for renal_fibrosis .
23950936	0	CTGF	33,37	Connective_tissue_growth_factor	0,31	CTGF	Connective tissue growth factor	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Connective_tissue_growth_factor -LRB- CTGF -RRB- expression modulates response to high glucose .
19500499	0	CTGF	40,44	ERK1/2	60,66	CTGF	ERK1/2	14219(Tax:10090)	26417;26413	Gene	Gene	expression|compound|START_ENTITY expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Losartan inhibits high glucose-induced CTGF expression via ERK1/2 MAPK pathways in mouse mesangial cells -RSB- .
19153601	0	CTGF	95,99	GPR30	11,16	CTGF	GPR30	1490	2852	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Estrogenic GPR30 signalling induces proliferation and migration of breast_cancer cells through CTGF .
25924590	0	CTGF	45,49	HMGB1	0,5	CTGF	HMGB1	1490	3146	Gene	Gene	Expression|nmod|START_ENTITY Enhances|dobj|Expression Enhances|nsubj|END_ENTITY	HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-b via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells .
23227240	0	CTGF	0,4	IL-6	15,19	CTGF	IL-6	1490	3569	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway .
19423687	0	CTGF	0,4	NF-kappaB	85,94	CTGF	NF-kappaB	14219(Tax:10090)	18033(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB .
22814105	0	CTGF	37,41	Oncostatin_M	0,12	CTGF	Oncostatin M	1490	5008	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Oncostatin_M inhibits TGF-b1-induced CTGF expression via STAT3 in human proximal tubular cells .
17074304	0	CTGF	46,50	PPAR-gamma	104,114	CTGF	PPAR-gamma	64032(Tax:10116)	25664(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Rosiglitazone inhibits angiotensin_II-induced CTGF expression in vascular smooth muscle cells - role of PPAR-gamma in vascular fibrosis .
21098624	0	CTGF	0,4	PROK1	35,40	CTGF	PROK1	1490	84432	Gene	Gene	expression|compound|START_ENTITY up-regulated|nsubj|expression up-regulated|nmod|END_ENTITY	CTGF expression is up-regulated by PROK1 in early pregnancy and influences HTR-8 / Svneo cell adhesion and network formation .
22814105	0	CTGF	37,41	STAT3	57,62	CTGF	STAT3	1490	6774	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Oncostatin_M inhibits TGF-b1-induced CTGF expression via STAT3 in human proximal tubular cells .
24005672	0	CTGF	79,83	Stat3	131,136	CTGF	Stat3	1490	6774	Gene	Gene	connective_tissue_growth_factor|appos|START_ENTITY connective_tissue_growth_factor|acl:relcl|requires requires|dobj|END_ENTITY	Transforming_growth_factor-b -LRB- TGF-b -RRB- - mediated connective_tissue_growth_factor -LRB- CTGF -RRB- expression in hepatic stellate cells requires Stat3 signaling activation .
20432467	0	CTGF	39,43	TGF-beta1	57,66	CCN2	TGF-beta1	14219(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|acl|induction induction|nmod|END_ENTITY	Src is a major signaling component for CTGF induction by TGF-beta1 in osteoblasts .
22732080	0	CTGF	27,31	TGFb1	108,113	CTGF	TGFb1	1490	7040	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Differential expression of CTGF in pre - and post-ovulatory granulosa cells in the hen ovary is regulated by TGFb1 and gonadotrophins .
17915216	0	CTGF	56,60	TGFbeta	0,7	CTGF	TGFbeta	1490	7040	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling .
22169285	0	CTGF	22,26	VEGF-C	28,34	CTGF	VEGF-C	1490	7424	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
22169285	0	CTGF	22,26	VEGFR-2	36,43	CTGF	VEGFR-2	1490	3791	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
21928342	0	CTGF	40,44	Wif-1	19,24	CTGF	Wif-1	14219(Tax:10090)	24117(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity .
10595311	0	CTGF	69,73	connective_tissue_growth_factor	36,67	CTGF	connective tissue growth factor	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of connective_tissue_growth_factor -LRB- CTGF -RRB- in the mouse embryo between days 7.5 and 14.5 of gestation .
11148599	0	CTGF	47,51	connective_tissue_growth_factor	14,45	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of connective_tissue_growth_factor -LRB- CTGF -RRB- mRNA in plaques of human anterior_subcapsular_cataracts and membranes of posterior capsule opacification .
15262182	0	CTGF	46,50	connective_tissue_growth_factor	13,44	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of connective_tissue_growth_factor -LRB- CTGF -RRB- in human endothelial cells by lysophosphatidic_acid , sphingosine-1-phosphate , and platelets .
16828074	0	CTGF	41,45	connective_tissue_growth_factor	8,39	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of connective_tissue_growth_factor -LRB- CTGF -RRB- module 4 in regulating epithelial mesenchymal transition -LRB- EMT -RRB- in HK-2 cells .
16937320	0	CTGF	50,54	connective_tissue_growth_factor	17,48	CTGF	connective tissue growth factor	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Taurine promotes connective_tissue_growth_factor -LRB- CTGF -RRB- expression in osteoblasts through the ERK signal pathway .
18586263	0	CTGF	72,76	connective_tissue_growth_factor	39,70	CTGF	connective tissue growth factor	64032(Tax:10116)	64032(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The Kruppel-like factor KLF15 inhibits connective_tissue_growth_factor -LRB- CTGF -RRB- expression in cardiac fibroblasts .
18586434	0	CTGF	48,52	connective_tissue_growth_factor	15,46	CTGF	connective tissue growth factor	281103(Tax:9913)	281103(Tax:9913)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of connective_tissue_growth_factor -LRB- CTGF -RRB- in insulin-like_growth_factor-I -LRB- IGF1 -RRB- stimulation of proliferation of a bovine mammary epithelial cell line .
18829614	0	CTGF	47,51	connective_tissue_growth_factor	14,45	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of connective_tissue_growth_factor -LRB- CTGF -RRB- by hepatocyte_growth_factor in human tubular epithelial cells .
21466783	0	CTGF	116,120	connective_tissue_growth_factor	83,114	CTGF	connective tissue growth factor	64032(Tax:10116)	64032(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Oral glucosamine increases expression of transforming_growth_factor_b1 -LRB- TGFb1 -RRB- and connective_tissue_growth_factor -LRB- CTGF -RRB- mRNA in rat cartilage and kidney : implications for human efficacy and toxicity .
22045431	0	CTGF	59,63	connective_tissue_growth_factor	26,57	CTGF	connective tissue growth factor	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A polymorphism within the connective_tissue_growth_factor -LRB- CTGF -RRB- gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes .
24275091	0	CTGF	77,81	connective_tissue_growth_factor	83,114	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Dual inhibition of Src family kinases and Aurora kinases by SU6656 modulates CTGF -LRB- connective_tissue_growth_factor -RRB- expression in an ERK-dependent manner .
25356109	0	CTGF	44,48	connective_tissue_growth_factor	11,42	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of connective_tissue_growth_factor -LRB- CTGF -RRB- gene silencing on the radiosensitivity of glioblastoma .
25727552	0	CTGF	76,80	connective_tissue_growth_factor	43,74	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The effect of 595 nm pulsed dye laser on connective_tissue_growth_factor -LRB- CTGF -RRB- expression in cultured keloid fibroblasts .
25847009	0	CTGF	56,60	connective_tissue_growth_factor	23,54	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Tumoural expression of connective_tissue_growth_factor -LRB- CTGF -RRB- impacts on survival in patients diagnosed with hepatocellular_carcinoma -LRB- HCC -RRB- .
9168990	0	CTGF	179,183	connective_tissue_growth_factor	146,177	CTGF	connective tissue growth factor	1490	1490	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective_tissue_growth_factor -LRB- CTGF -RRB- mRNA .
17602195	0	CTGF	20,24	glucocorticoid_receptor	65,88	CTGF	glucocorticoid receptor	1490	2908	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid_receptor .
18829614	0	CTGF	47,51	hepatocyte_growth_factor	56,80	CTGF	hepatocyte growth factor	1490	3082	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of connective_tissue_growth_factor -LRB- CTGF -RRB- by hepatocyte_growth_factor in human tubular epithelial cells .
26873752	0	CTGF	32,36	miR-19a	0,7	CTGF	miR-19a	1490	406979	Gene	Gene	Expression|compound|START_ENTITY Expression|dep|END_ENTITY	miR-19a , -19 b , and -26 b Mediate CTGF Expression and Pulmonary Fibroblast Differentiation .
23274856	0	CTGF	0,4	monocyte_chemoattractant_protein-1	13,47	CTGF	monocyte chemoattractant protein-1	1490	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	CTGF induces monocyte_chemoattractant_protein-1 expression to enhance monocyte migration in human synovial fibroblasts .
25601519	0	CTGF	80,84	sphingosine_1-phosphate_receptor_5	106,140	CTGF	sphingosine 1-phosphate receptor 5	1490	53637	Gene	Gene	connective_tissue_growth_factor|appos|START_ENTITY connective_tissue_growth_factor|acl:relcl|requires requires|dobj|END_ENTITY	Transforming_growth_factor_b2 -LRB- TGF-b2 -RRB- - induced connective_tissue_growth_factor -LRB- CTGF -RRB- expression requires sphingosine_1-phosphate_receptor_5 -LRB- S1P5 -RRB- in human mesangial cells .
23816882	0	CTGF	0,4	transforming_growth_factor_b	29,57	CTGF	transforming growth factor b	14219(Tax:10090)	21803(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	CTGF mediates Smad-dependent transforming_growth_factor_b signaling to regulate mesenchymal cell proliferation during palate development .
26664254	0	CTHRC1	43,49	Collagen_Triple_Helix_Repeat_Containing-1	0,41	CTHRC1	Collagen Triple Helix Repeat Containing-1	115908	115908	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Collagen_Triple_Helix_Repeat_Containing-1 -LRB- CTHRC1 -RRB- Expression in Oral_Squamous_Cell_Carcinoma -LRB- OSCC -RRB- : Prognostic Value and Clinico-Pathological Implications .
23658133	0	CTHRC1	43,49	Collagen_triple_helix_repeat_containing-1	0,41	CTHRC1	Collagen triple helix repeat containing-1	115908	115908	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Collagen_triple_helix_repeat_containing-1 -LRB- CTHRC1 -RRB- expression in invasive_ductal_carcinoma of the breast : the impact on prognosis and correlation to clinicopathologic features .
17631058	0	CTIP2	45,50	COUP-TF-interacting_protein_2	14,43	CTIP2	COUP-TF-interacting protein 2	58208(Tax:10090)	58208(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of COUP-TF-interacting_protein_2 -LRB- CTIP2 -RRB- in mouse skin during development and in adulthood .
19366371	0	CTIP2	45,50	COUP-TF-interacting_protein_2	14,43	CTIP2	COUP-TF-interacting protein 2	64919	64919	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of COUP-TF-interacting_protein_2 -LRB- CTIP2 -RRB- in human atopic_dermatitis and allergic_contact_dermatitis skin .
9256472	0	CTLA-4	15,21	AP50	27,31	CTLA-4	AP50	12477(Tax:10090)	1173	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CTLA-4 with AP50 , a clathrin-coated pit adaptor protein .
11279502	0	CTLA-4	30,36	B7-1	25,29	CTLA-4	B7-1	1493	941	Gene	Gene	complex|compound|START_ENTITY complex|dep|Crystal Crystal|dobj|structure structure|nmod|END_ENTITY	Crystal structure of the B7-1 / CTLA-4 complex that inhibits human immune responses .
11877291	0	CTLA-4	19,25	B7-1	69,73	CTLA-4	B7-1	12477(Tax:10090)	12519(Tax:10090)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|immunity immunity|nmod|vivo vivo|nmod|+ +|compound|END_ENTITY	Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1 + , but not B7-2 + , murine myelogenous_leukemia .
8557978	0	CTLA-4	24,30	B7-1	75,79	CTLA-4	B7-1	1493	941	Gene	Gene	effects|nmod|START_ENTITY substitutions|nsubj|effects substitutions|nmod|the the|nmod|CD80 CD80|appos|END_ENTITY	Differential effects of CTLA-4 substitutions on the binding of human CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- .
9815249	0	CTLA-4	151,157	B7-1	146,150	CTLA-4	B7-1	12477(Tax:10090)	12519(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Unresponsive CD4 + T lymphocytes from Leishmania chagasi-infected mice increase cytokine production and mediate parasite killing after blockade of B7-1 / CTLA-4 molecular pathway .
8557978	0	CTLA-4	24,30	B7-2	91,95	CTLA-4	B7-2	1493	942	Gene	Gene	effects|nmod|START_ENTITY substitutions|nsubj|effects substitutions|nmod|the the|nmod|CD80 CD80|appos|END_ENTITY	Differential effects of CTLA-4 substitutions on the binding of human CD80 -LRB- B7-1 -RRB- and CD86 -LRB- B7-2 -RRB- .
22319577	0	CTLA-4	23,29	CCR4	16,20	CTLA-4	CCR4	1493	1233	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Accumulation of CCR4 CTLA-4 FOXP3 CD25 -LRB- hi -RRB- regulatory T cells in colon_adenocarcinomas correlate to reduced activation of conventional T cells .
10193417	0	CTLA-4	23,29	CD152	31,36	CTLA-4	CD152	1493	1493	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of CTLA-4 -LRB- CD152 -RRB- on CD4 + T cells in HIV_infection .
17020649	0	CTLA-4	20,26	CD152	13,18	CTLA-4	CD152	1493	1493	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- The surface CD152 -LRB- CTLA-4 -RRB- expression on peripheral blood lymphocytes in children with Hashimoto 's _ thyroiditis -RSB- .
20134044	0	CTLA-4	21,27	CD152	14,19	CTLA-4	CD152	1493	1493	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD152 -LRB- CTLA-4 -RRB- in children with autoimmune_thyroiditis and +49 _ A/G polymorphism of exon 1 of the CTLA-4 gene .
9749982	0	CTLA-4	14,20	CD152	22,27	CTLA-4	CD152	1493	1493	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CTLA-4 -LRB- CD152 -RRB- on human medullary CD4 + thymocytes .
11801641	0	CTLA-4	54,60	CD25	0,4	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	immunoregulation|amod|START_ENTITY +|dobj|immunoregulation +|nsubj|CD4 CD4|compound|END_ENTITY	CD25 + CD4 + regulatory T cells prevent graft rejection : CTLA-4 - and IL-10-dependent immunoregulation of alloresponses .
12355442	0	CTLA-4	44,50	CD25	78,82	CTLA-4	CD25	1493	3559	Gene	Gene	utilizes|compound|START_ENTITY Inhibition|nmod|utilizes CD80|nsubj|Inhibition CD80|dobj|cells cells|nummod|+ +|compound|END_ENTITY	Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25 + regulatory T cells .
15295006	0	CTLA-4	9,15	CD25	39,43	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY induces|nsubj|engagement induces|dobj|cells cells|compound|END_ENTITY	Targeted CTLA-4 engagement induces CD4 + CD25 + CTLA-4high T regulatory cells with target -LRB- allo -RRB- antigen specificity .
15724061	0	CTLA-4	84,90	CD25	0,4	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY exert|nmod|independent cells|acl|exert CD4|dep|cells CD4|compound|END_ENTITY	CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells exert in vitro suppressive activity independent of CTLA-4 .
16982872	0	CTLA-4	12,18	CD25	26,30	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Blockade of CTLA-4 on CD4 + CD25 + regulatory T cells abrogates their function in vivo .
17878360	0	CTLA-4	0,6	CD25	16,20	CTLA-4	CD25	1493	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CTLA-4 and CD4 + CD25 + regulatory T cells inhibit protective immunity to filarial parasites in vivo .
17911604	0	CTLA-4	23,29	CD25	59,63	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	engagement|nmod|START_ENTITY induces|nsubj|engagement induces|dobj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18272926	0	CTLA-4	0,6	CD25	31,35	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	Ig|compound|START_ENTITY converts|nsubj|Ig converts|dobj|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CTLA-4	0,6	CD25	54,58	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	Ig|compound|START_ENTITY converts|nsubj|Ig converts|dobj|CD25 CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18397268	0	CTLA-4	63,69	CD25	77,81	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4 + CD25 + T cells .
18641304	0	CTLA-4	111,117	CD25	60,64	CTLA-4	CD25	1493	3559	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression function|parataxis|associated function|nmod|END_ENTITY	Acquisition of suppressive function by activated human CD4 + CD25 - T cells is associated with the expression of CTLA-4 not FoxP3 .
19462377	0	CTLA-4	0,6	CD25	26,30	CTLA-4	CD25	1493	3559	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|Treg Treg|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
22749982	0	CTLA-4	20,26	CD25	66,70	CTLA-4	CD25	1493	3559	Gene	Gene	CD152|appos|START_ENTITY Induction|nmod|CD152 Induction|dep|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
25111463	0	CTLA-4	110,116	CD25	39,43	CTLA-4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY effect|nmod|blockade essential|nmod|effect essential|dep|Breaking Breaking|advcl|targeting targeting|dobj|+ +|compound|END_ENTITY	Breaking immune tolerance by targeting CD25 + regulatory T cells is essential for the anti-tumor effect of the CTLA-4 blockade in an HLA-DR transgenic mouse model of prostate_cancer .
10713366	0	CTLA-4	37,43	CD28	90,94	CTLA-4	CD28	1493	940	Gene	Gene	gene|compound|START_ENTITY expansion|nmod|gene leads|nsubj|expansion leads|xcomp|T T|dobj|hyper-reactivity hyper-reactivity|nmod|pathway pathway|compound|END_ENTITY	Dinucleotide repeat expansion in the CTLA-4 gene leads to T cell hyper-reactivity via the CD28 pathway in myasthenia_gravis .
12525576	0	CTLA-4	66,72	CD28	36,40	CTLA-4	CD28	1493	940	Gene	Gene	convert|dobj|START_ENTITY sufficient|xcomp|convert sufficient|nsubj|segment segment|nmod|END_ENTITY	Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor .
12956876	0	CTLA-4	84,90	CD28	30,34	CTLA-4	CD28	1493	940	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of CD28 and cytotoxic_T-lymphocyte-associated_antigen_4 -LRB- CTLA-4 -RRB- of woodchuck -LRB- Marmota monax -RRB- .
16903911	0	CTLA-4	55,61	CD28	12,16	CTLA-4	CD28	1493	940	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of CD28 and cytotoxic_T-lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- in regulatory T-cell biology .
17702861	0	CTLA-4	35,41	CD28	72,76	CTLA-4	CD28	12477(Tax:10090)	12487(Tax:10090)	Gene	Gene	autoimmune_disease|nmod|START_ENTITY mice|amod|autoimmune_disease Induction|nmod|mice depends|nsubj|Induction depends|nmod|motif motif|compound|END_ENTITY	Induction of autoimmune_disease in CTLA-4 - / - mice depends on a specific CD28 motif that is required for in vivo costimulation .
18162511	0	CTLA-4	49,55	CD28	14,18	CTLA-4	CD28	1493	940	Gene	Gene	T|nmod|START_ENTITY T|nsubj|Regulation Regulation|nmod|expression expression|nummod|END_ENTITY	Regulation of CD28 expression on CD8 + T cells by CTLA-4 .
23045162	0	CTLA-4	14,20	CD28	21,25	CTLA-4	CD28	1493	940	Gene	Gene	Impact|nmod|START_ENTITY Impact|dep|axis axis|nummod|END_ENTITY	Impact of the CTLA-4 / CD28 axis on the processes of joint inflammation in rheumatoid_arthritis .
25548162	0	CTLA-4	0,6	CD28	87,91	CTLA-4	CD28	12477(Tax:10090)	12487(Tax:10090)	Gene	Gene	controls|dep|START_ENTITY controls|dep|regulating regulating|dobj|strength strength|nmod|engagement engagement|compound|END_ENTITY	CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement .
9228944	0	CTLA-4	28,34	CD28	92,96	CTLA-4	CD28	1493	940	Gene	Gene	structure|nmod|START_ENTITY conserved|nsubj|structure conserved|nmod|END_ENTITY	Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28 .
9780158	0	CTLA-4	76,82	CD28	83,87	CTLA-4	CD28	100765782	100769830	Gene	Gene	CD80|compound|START_ENTITY CD80|compound|END_ENTITY	Positive and negative regulation of human T cell activation mediated by the CTLA-4 / CD28 ligand CD80 .
10190907	0	CTLA-4	45,51	CD4	152,155	CTLA-4	CD4	1493	920	Gene	Gene	antigen|appos|START_ENTITY regulate|nsubj|antigen regulate|dobj|activation activation|advmod|independently independently|nmod|T T|compound|END_ENTITY	Cytotoxic T lymphocyte-associated antigen 4 -LRB- CTLA-4 -RRB- can regulate dendritic cell-induced activation and cytotoxicity of CD8 -LRB- + -RRB- T cells independently of CD4 -LRB- + -RRB- T cell help .
10411922	0	CTLA-4	34,40	CD4	91,94	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cytotoxic_T_lymphocyte_antigen-4|appos|START_ENTITY regulates|nsubj|Cytotoxic_T_lymphocyte_antigen-4 regulates|ccomp|T T|nsubj|END_ENTITY	Cytotoxic_T_lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- regulates primary and secondary peptide-specific CD4 -LRB- + -RRB- T cell responses .
10549630	0	CTLA-4	0,6	CD4	61,64	CTLA-4	CD4	1493	920	Gene	Gene	blockade|compound|START_ENTITY reverses|nsubj|blockade reverses|nmod|cell cell|compound|END_ENTITY	CTLA-4 blockade reverses CD8 + T cell tolerance to tumor by a CD4 + T cell - and IL-2-dependent mechanism .
10632663	0	CTLA-4	9,15	CD4	30,33	CTLA-4	CD4	1493	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Elevated CTLA-4 expression on CD4 T cells from periodontitis patients stimulated with Porphyromonas_gingivalis outer membrane antigen .
10725710	0	CTLA-4	60,66	CD4	22,25	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	costimulation|compound|START_ENTITY +|nmod|costimulation +|nsubj|Polarization Polarization|nmod|END_ENTITY	Polarization of naive CD4 + T cells toward the Th1 subset by CTLA-4 costimulation .
10744647	0	CTLA-4	69,75	CD4	11,14	CTLA-4	CD4	1493	920	Gene	Gene	re-stimulation|nmod|START_ENTITY fate|nmod|re-stimulation fate|compound|END_ENTITY	Control of CD4 T cell fate by antigen re-stimulation with or without CTLA-4 engagement 24 h after priming .
10882627	0	CTLA-4	76,82	CD4	0,3	CTLA-4	CD4	1493	920	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|lymphocytes lymphocytes|compound|END_ENTITY	CD4 alphabeta T lymphocytes express high levels of the T lymphocyte antigen CTLA-4 -LRB- CD152 -RRB- in acute_malaria .
11050166	0	CTLA-4	34,40	CD4	107,110	CTLA-4	CD4	1493	920	Gene	Gene	Cytotoxic_T_lymphocyte_antigen-4|appos|START_ENTITY regulates|nsubj|Cytotoxic_T_lymphocyte_antigen-4 regulates|dobj|size size|nmod|pool pool|nmod|cells cells|compound|END_ENTITY	Cytotoxic_T_lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- regulates the size , reactivity , and function of a primed pool of CD4 + T cells .
11801641	0	CTLA-4	54,60	CD4	5,8	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	immunoregulation|amod|START_ENTITY +|dobj|immunoregulation +|nsubj|END_ENTITY	CD25 + CD4 + regulatory T cells prevent graft rejection : CTLA-4 - and IL-10-dependent immunoregulation of alloresponses .
11970985	0	CTLA-4	0,6	CD4	58,61	CTLA-4	CD4	1493	920	Gene	Gene	suppresses|compound|START_ENTITY proximal|nsubj|suppresses proximal|dep|signaling signaling|nmod|END_ENTITY	CTLA-4 suppresses proximal TCR signaling in resting human CD4 -LRB- + -RRB- T cells by inhibiting ZAP-70 Tyr -LRB- 319 -RRB- phosphorylation : a potential role for tyrosine phosphatases .
12244135	0	CTLA-4	14,20	CD4	159,162	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|kinases kinases|nmod|cells cells|compound|END_ENTITY	Cutting edge : CTLA-4 -LRB- CD152 -RRB- differentially regulates mitogen-activated protein kinases -LRB- extracellular_signal-regulated_kinase and c-Jun_N-terminal_kinase -RRB- in CD4 + T cells from receptor/ligand-deficient mice .
12444128	0	CTLA-4	60,66	CD4	93,96	CTLA-4	CD4	1493	920	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|T T|compound|END_ENTITY	Cyclic_adenosine_5 ' - monophosphate and calcium induce CD152 -LRB- CTLA-4 -RRB- up-regulation in resting CD4 + T lymphocytes .
15295006	0	CTLA-4	9,15	CD4	35,38	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY induces|nsubj|engagement induces|dobj|cells cells|compound|END_ENTITY	Targeted CTLA-4 engagement induces CD4 + CD25 + CTLA-4high T regulatory cells with target -LRB- allo -RRB- antigen specificity .
15468055	0	CTLA-4	18,24	CD4	41,44	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|function function|compound|END_ENTITY	Distinct roles of CTLA-4 and TGF-beta in CD4 + CD25 + regulatory T cell function .
15484187	0	CTLA-4	78,84	CD4	32,35	CTLA-4	CD4	1493	920	Gene	Gene	expression|compound|START_ENTITY dependent|nmod|expression dependent|nsubj|properties properties|nmod|cells cells|compound|END_ENTITY	Suppressive properties of human CD4 + CD25 + regulatory T cells are dependent on CTLA-4 expression .
15585846	0	CTLA-4	0,6	CD4	37,40	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY acts|nsubj|engagement acts|nmod|proliferation proliferation|compound|END_ENTITY	CTLA-4 engagement acts as a brake on CD4 + T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance .
16221546	0	CTLA-4	40,46	CD4	68,71	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY eicosapentaenoic_acid|dobj|expression eicosapentaenoic_acid|nmod|T-cells T-cells|compound|END_ENTITY	Dietary eicosapentaenoic_acid modulates CTLA-4 expression in murine CD4 + T-cells .
16882704	0	CTLA-4	0,6	CD4	68,71	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	dysregulation|compound|START_ENTITY T-cell|nsubj|dysregulation T-cell|compound|END_ENTITY	CTLA-4 dysregulation of self/tumor-reactive CD8 + T-cell function is CD4 + T-cell dependent .
16887994	0	CTLA-4	69,75	CD4	33,36	CTLA-4	CD4	1493	920	Gene	Gene	signaling|compound|START_ENTITY facilitated|nmod|signaling facilitated|nsubjpass|suppression suppression|nmod|cells cells|compound|END_ENTITY	TGF-beta-mediated suppression by CD4 + CD25 + T cells is facilitated by CTLA-4 signaling .
16982872	0	CTLA-4	12,18	CD4	22,25	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Blockade of CTLA-4 on CD4 + CD25 + regulatory T cells abrogates their function in vivo .
17015751	0	CTLA-4	97,103	CD4	62,65	CTLA-4	CD4	1493	920	Gene	Gene	signaling|compound|START_ENTITY +|nmod|signaling +|nsubj|Induction Induction|nmod|suppressors suppressors|nmod|patients patients|nmod|END_ENTITY	Induction of IL-10 suppressors in lung transplant patients by CD4 +25 + regulatory T cells through CTLA-4 signaling .
17404100	0	CTLA-4	9,15	CD4	67,70	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY ameliorates|nsubj|blockade ameliorates|nmod|compartment compartment|compound|END_ENTITY	Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4 + T cell compartment without affecting regulatory T-cell function .
17906628	0	CTLA-4	16,22	CD4	39,42	CTLA-4	CD4	1493	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Upregulation of CTLA-4 by HIV-specific CD4 + T cells correlates with disease progression and defines a reversible immune_dysfunction .
17911604	0	CTLA-4	23,29	CD4	55,58	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|nmod|START_ENTITY induces|nsubj|engagement induces|dobj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18272926	0	CTLA-4	0,6	CD4	27,30	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	Ig|compound|START_ENTITY converts|nsubj|Ig converts|dobj|CD25 CD25|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18272926	0	CTLA-4	0,6	CD4	50,53	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	Ig|compound|START_ENTITY converts|nsubj|Ig converts|dobj|CD25 CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	CTLA-4 x Ig converts naive CD4 + CD25 - T cells into CD4 + CD25 + regulatory T cells .
18397268	0	CTLA-4	63,69	CD4	73,76	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4 + CD25 + T cells .
18641304	0	CTLA-4	111,117	CD4	55,58	CTLA-4	CD4	1493	920	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression function|parataxis|associated function|nmod|CD25 CD25|compound|END_ENTITY	Acquisition of suppressive function by activated human CD4 + CD25 - T cells is associated with the expression of CTLA-4 not FoxP3 .
18818309	0	CTLA-4	0,6	CD4	45,48	CTLA-4	CD4	1493	920	Gene	Gene	blockade|compound|START_ENTITY increases|nsubj|blockade increases|dobj|cells cells|compound|END_ENTITY	CTLA-4 blockade increases IFNgamma-producing CD4 + ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients .
19179471	0	CTLA-4	0,6	CD4	23,26	CTLA-4	CD4	1493	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance .
19188497	0	CTLA-4	32,38	CD4	0,3	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	require|dobj|START_ENTITY require|nsubj|cells cells|nummod|END_ENTITY	CD4 + regulatory T cells require CTLA-4 for the maintenance of systemic tolerance .
19462377	0	CTLA-4	0,6	CD4	22,25	CTLA-4	CD4	1493	920	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|Treg Treg|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19462377	0	CTLA-4	0,6	CD4	48,51	CTLA-4	CD4	1493	920	Gene	Gene	required|nsubjpass|START_ENTITY required|xcomp|control control|dobj|proliferation proliferation|compound|END_ENTITY	CTLA-4 is required by CD4 + CD25 + Treg to control CD4 + T-cell lymphopenia-induced proliferation .
19479036	0	CTLA-4	7,13	CD4	26,29	CTLA-4	CD4	1493	920	Gene	Gene	CD152|appos|START_ENTITY determines|nsubj|CD152 determines|dobj|migration migration|compound|END_ENTITY	CD152 -LRB- CTLA-4 -RRB- determines CD4 T cell migration in vitro and in vivo .
21170302	0	CTLA-4	74,80	CD4	0,3	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	cerebral_malaria|nmod|START_ENTITY prevent|dobj|cerebral_malaria prevent|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + natural regulatory T cells prevent experimental cerebral_malaria via CTLA-4 when expanded in vivo .
21478403	0	CTLA-4	12,18	CD4	70,73	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	Blockade|nmod|START_ENTITY decreases|nsubj|Blockade decreases|dobj|generation generation|nmod|cells cells|compound|END_ENTITY	Blockade of CTLA-4 decreases the generation of multifunctional memory CD4 + T cells in vivo .
21620894	0	CTLA-4	4,10	CD4	25,28	CTLA-4	CD4	1493	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Low CTLA-4 expression in CD4 + helper T-cells in patients with fulminant type 1 diabetes .
22105491	0	CTLA-4	82,88	CD4	19,22	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY ablates|dobj|expression ablates|nsubj|engagement engagement|nmod|cells cells|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
22403258	0	CTLA-4	9,15	CD4	56,59	CTLA-4	CD4	1493	920	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Basis of CTLA-4 function in regulatory and conventional CD4 -LRB- + -RRB- T cells .
22749982	0	CTLA-4	20,26	CD4	61,64	CTLA-4	CD4	1493	920	Gene	Gene	CD152|appos|START_ENTITY Induction|nmod|CD152 Induction|dep|CD25 CD25|compound|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22878899	0	CTLA-4	34,40	CD4	30,33	CTLA-4	CD4	1493	920	Gene	Gene	frequency|compound|START_ENTITY frequency|compound|END_ENTITY	T cell profiling reveals high CD4 + CTLA-4 + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment .
24173147	0	CTLA-4	13,19	CD4	118,121	CTLA-4	CD4	1493	920	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|NFAT1 NFAT1|nmod|proliferation proliferation|compound|END_ENTITY	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
24173147	0	CTLA-4	13,19	CD4	40,43	CTLA-4	CD4	1493	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
24312642	0	CTLA-4	67,73	CD4	52,55	CTLA-4	CD4	1493	920	Gene	Gene	dependent|amod|START_ENTITY manner|amod|dependent Treg|nmod|manner Treg|compound|END_ENTITY	ICOS regulates the generation and function of human CD4 + Treg in a CTLA-4 dependent manner .
25241783	0	CTLA-4	46,52	CD4	78,81	CTLA-4	CD4	397286(Tax:9823)	404704(Tax:9823)	Gene	Gene	molecules|amod|START_ENTITY molecules|nmod|cells cells|compound|END_ENTITY	-LSB- Expression levels of co-inhibitory molecules CTLA-4 , LAG-3 , PD-1 and CD39 on CD4 T cells correlate with progression of non-small_cell_lung_cancer -RSB- .
26601915	0	CTLA-4	58,64	CD4	51,54	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|iobj|+ +|compound|END_ENTITY	Glutamate_receptor_interacting_protein_1 regulates CD4 -LRB- + -RRB- CTLA-4 expression and transplant rejection .
8113677	0	CTLA-4	45,51	CD4	96,99	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	form|nmod|START_ENTITY transgenic|nmod|form Mice|amod|transgenic show|nsubj|Mice show|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4 + T cells and defective antibody production in vivo .
9493288	0	CTLA-4	40,46	CD4	66,69	CTLA-4	CD4	1493	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Nonresponsiveness and susceptibility to CTLA-4 of antigen-exposed CD4 T cells are not regulated by the Bcl-2 family of apoptotic mediators , but can be restored by IL-2 .
9551948	0	CTLA-4	0,6	CD4	58,61	CTLA-4	CD4	1493	920	Gene	Gene	ligation|compound|START_ENTITY delivers|nsubj|ligation delivers|nmod|cells cells|compound|END_ENTITY	CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X -LRB- L -RRB- induction .
9707604	0	CTLA-4	67,73	CD4	35,38	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	crosslinking|compound|START_ENTITY induced|nmod|crosslinking lymphocytes|dep|induced lymphocytes|nsubj|death death|nmod|T T|compound|END_ENTITY	Fas-independent death of activated CD4 -LRB- + -RRB- T lymphocytes induced by CTLA-4 crosslinking .
9749982	0	CTLA-4	14,20	CD4	48,51	CTLA-4	CD4	1493	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|thymocytes thymocytes|compound|END_ENTITY	Expression of CTLA-4 -LRB- CD152 -RRB- on human medullary CD4 + thymocytes .
9815262	0	CTLA-4	59,65	CD4	139,142	CTLA-4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytotoxic_T_lymphocyte-associated_antigen_4|appos|START_ENTITY Engagement|nmod|cytotoxic_T_lymphocyte-associated_antigen_4 induces|nsubj|Engagement induces|xcomp|transforming transforming|dobj|cells cells|compound|factor factor|dep|production production|nmod|T T|compound|END_ENTITY	Engagement of cytotoxic_T_lymphocyte-associated_antigen_4 -LRB- CTLA-4 -RRB- induces transforming growth factor beta -LRB- TGF-beta -RRB- production by murine CD4 -LRB- + -RRB- T cells .
9834064	0	CTLA-4	21,27	CD4	73,76	CTLA-4	CD4	1493	920	Gene	Gene	role|nmod|START_ENTITY role|nmod|memory memory|nmod|activation activation|compound|END_ENTITY	Differential role of CTLA-4 in regulation of resting memory versus naive CD4 T cell activation .
22105491	0	CTLA-4	82,88	CD40	24,28	CTLA-4	CD40	12477(Tax:10090)	21939(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY ablates|dobj|expression ablates|nsubj|engagement engagement|nmod|cells cells|compound|END_ENTITY	CD40 engagement of CD4 + CD40 + T cells in a neo-self antigen disease model ablates CTLA-4 expression and indirectly impacts tolerance .
11135579	0	CTLA-4	0,6	CD45	59,63	CTLA-4	CD45	1493	5788	Gene	Gene	up-regulation|compound|START_ENTITY plays|nsubj|up-regulation plays|dobj|role role|nmod|tolerance tolerance|acl|mediated mediated|nmod|END_ENTITY	CTLA-4 up-regulation plays a role in tolerance mediated by CD45 .
22783574	0	CTLA-4	11,17	CD45	6,10	CTLA-4	CD45	1493	5788	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	CD40 , CD45 CTLA-4 levels are elevated in healthy older adults .
19247441	0	CTLA-4	89,95	CD8	50,53	CTLA-4	CD8	1493	925	Gene	Gene	blockade|compound|START_ENTITY exhaustion|nmod|blockade exhaustion|nsubj|reversal reversal|nmod|cell cell|compound|END_ENTITY	Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1 / CTLA-4 blockade .
17130562	0	CTLA-4	13,19	CT60	25,29	CTLA-4	CT60	1493	348120	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin_D_receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related_type_1_diabetes in the Japanese .
24697361	0	CTLA-4	0,6	CT60	7,11	CTLA-4	CT60	1493	348120	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	CTLA-4 CT60 -LRB- rs3087243 -RRB- polymorphism and autoimmune thyroid_diseases susceptibility : a comprehensive meta-analysis .
22319577	0	CTLA-4	23,29	FOXP3	30,35	CTLA-4	FOXP3	1493	50943	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Accumulation of CCR4 CTLA-4 FOXP3 CD25 -LRB- hi -RRB- regulatory T cells in colon_adenocarcinomas correlate to reduced activation of conventional T cells .
21088216	0	CTLA-4	15,21	FasL	23,27	CTLA-4	FasL	1493	356	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	CD40 FasL and CTLA-4 FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling .
16517699	0	CTLA-4	18,24	FoxP3	65,70	CTLA-4	FoxP3	12477(Tax:10090)	20371(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|xcomp|induce induce|dobj|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
17911604	0	CTLA-4	23,29	Foxp3	64,69	CTLA-4	Foxp3	12477(Tax:10090)	20371(Tax:10090)	Gene	Gene	engagement|nmod|START_ENTITY induces|nsubj|engagement induces|dobj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18845758	0	CTLA-4	0,6	Foxp3	20,25	CTLA-4	Foxp3	1493	50943	Gene	Gene	control|compound|START_ENTITY control|nmod|cell cell|amod|END_ENTITY	CTLA-4 control over Foxp3 + regulatory T cell function .
22749982	0	CTLA-4	20,26	Foxp3	54,59	CTLA-4	Foxp3	1493	50943	Gene	Gene	CD152|appos|START_ENTITY Induction|nmod|CD152 Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22910217	0	CTLA-4	0,6	Foxp3	16,21	CTLA-4	Foxp3	1493	50943	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|induction induction|amod|END_ENTITY	CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria .
24007441	0	CTLA-4	112,118	Foxp3	66,71	CTLA-4	Foxp3	1493	50943	Gene	Gene	Ig|compound|START_ENTITY absence|nmod|Ig iTreg|nmod|absence END_ENTITY|acl|iTreg	An anti-CD154 domain antibody prolongs graft survival and induces Foxp3 -LRB- + -RRB- iTreg in the absence and presence of CTLA-4 Ig .
23423978	0	CTLA-4	29,35	GARP	22,26	CTLA-4	GARP	1493	1258	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|amod|END_ENTITY	Higher frequencies of GARP -LRB- + -RRB- CTLA-4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T regulatory cells and myeloid-derived suppressor cells in hepatocellular_carcinoma patients are associated with impaired T-cell functionality .
26601915	0	CTLA-4	58,64	Glutamate_receptor_interacting_protein_1	0,40	CTLA-4	Glutamate Receptor Interacting Protein 1	12477(Tax:10090)	74053(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glutamate_receptor_interacting_protein_1 regulates CD4 -LRB- + -RRB- CTLA-4 expression and transplant rejection .
15634884	0	CTLA-4	17,23	IL-10	0,5	CTLA-4	IL-10	12477(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY diminishes|dobj|expression diminishes|nsubj|END_ENTITY	IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance .
17015751	0	CTLA-4	97,103	IL-10	13,18	CTLA-4	IL-10	1493	3586	Gene	Gene	signaling|compound|START_ENTITY +|nmod|signaling +|nsubj|Induction Induction|nmod|suppressors suppressors|compound|END_ENTITY	Induction of IL-10 suppressors in lung transplant patients by CD4 +25 + regulatory T cells through CTLA-4 signaling .
22547705	0	CTLA-4	7,13	IL-10	0,5	CTLA-4	IL-10	1493	3586	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-10 + CTLA-4 + Th2 inhibitory cells form in a Foxp3-independent , IL-2-dependent manner from Th2 effectors during chronic_inflammation .
23960017	0	CTLA-4	12,18	IL-10	118,123	CTLA-4	IL-10	1493	3586	Gene	Gene	START_ENTITY|acl|+ +|ccomp|suppress suppress|nmod|END_ENTITY	Human CD14 + CTLA-4 + regulatory dendritic cells suppress T-cell response by cytotoxic_T-lymphocyte_antigen-4-dependent IL-10 and indoleamine-2 ,3 - dioxygenase production in hepatocellular_carcinoma .
19247441	0	CTLA-4	89,95	PD-1	84,88	CTLA-4	PD-1	1493	5133	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1 / CTLA-4 blockade .
15870282	0	CTLA-4	109,115	Rap1	31,35	CTLA-4	Rap1	12477(Tax:10090)	109905(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the small GTPase Rap1 and extracellular_signal-regulated_kinases by the costimulatory molecule CTLA-4 .
16476059	0	CTLA-4	0,6	STAT5	22,27	CTLA-4	STAT5	1493	6776	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription .
16517699	0	CTLA-4	18,24	TGF-beta	0,8	CTLA-4	TGF-beta	12477(Tax:10090)	21803(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
20016783	0	CTLA-4	75,81	TGF-beta	0,8	CTLA-4	TGF-beta	1493	7040	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	TGF-beta and IL-10 production by HIV-specific CD8 + T cells is regulated by CTLA-4 signaling on CD4 + T cells .
18479065	0	CTLA-4	61,67	VP2	75,78	CTLA-4	VP2	12477(Tax:10090)	1489588(Tax:10788)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	-LSB- Immunoadjuvant effect of the extracellular domain of canine CTLA-4 on the VP2 protein of canine_parvovirus -RSB- .
12534352	0	CTLA-4	60,66	cytotoxic_T-lymphocyte-associated_antigen-4	15,58	CTLA-4	cytotoxic T-lymphocyte-associated antigen-4	1493	1493	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of cytotoxic_T-lymphocyte-associated_antigen-4 -LRB- CTLA-4 -RRB- gene polymorphism and non-genetic factors with Graves ' _ ophthalmopathy in European and Japanese populations .
10197076	0	CTLA-4	36,42	cytotoxic_T_lymphocyte_antigen-4	2,34	CTLA-4	cytotoxic T lymphocyte antigen-4	1493	1493	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	A cytotoxic_T_lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- gene polymorphism is associated with autoimmune_Addison 's _ disease in English patients .
19147248	0	CTLA-4	85,91	cytotoxic_T_lymphocyte_antigen_4	51,83	CTLA-4	cytotoxic T lymphocyte antigen 4	1493	1493	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interactions between programmed_death_1 -LRB- PD-1 -RRB- and cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA-4 -RRB- gene polymorphisms in type 1 diabetes .
15322168	0	CTLA4	34,39	CD25	29,33	CTLA4	CD25	1493	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional maturation of CD4 + CD25 + CTLA4 + CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens .
16224273	0	CTLA4	78,83	CD25	73,77	CTLA4	CD25	12477(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	LF 15-0195 generates synergistic tolerance by promoting formation of CD4 + CD25 + CTLA4 + T cells .
19173720	0	CTLA4	83,88	CD25	21,25	CTLA4	CD25	1493	3559	Gene	Gene	variants|compound|START_ENTITY associated|nmod|variants trait|acl|associated frequency|dep|trait frequency|nmod|Treg Treg|compound|END_ENTITY	Low frequency of CD4 + CD25 + Treg in SLE patients : a heritable trait associated with CTLA4 and TGFbeta gene variants .
9653096	0	CTLA4	128,133	CD28	164,168	CTLA4	CD28	12477(Tax:10090)	12487(Tax:10090)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	Cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA4 -RRB- blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice : CTLA4 can function independently of CD28 .
15322168	0	CTLA4	34,39	CD4	25,28	CTLA4	CD4	1493	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Functional maturation of CD4 + CD25 + CTLA4 + CD45RA + T regulatory cells in human neonatal T cell responses to environmental antigens/allergens .
16224273	0	CTLA4	78,83	CD4	69,72	CTLA4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	LF 15-0195 generates synergistic tolerance by promoting formation of CD4 + CD25 + CTLA4 + T cells .
18641318	0	CTLA4	0,5	CD4	63,66	CTLA4	CD4	1493	920	Gene	Gene	expression|compound|START_ENTITY indicator|nsubj|expression indicator|nmod|homeostasis homeostasis|compound|END_ENTITY	CTLA4 expression is an indicator and regulator of steady-state CD4 + FoxP3 + T cell homeostasis .
19173720	0	CTLA4	83,88	CD4	17,20	CTLA4	CD4	1493	920	Gene	Gene	variants|compound|START_ENTITY associated|nmod|variants trait|acl|associated frequency|dep|trait frequency|nmod|Treg Treg|compound|END_ENTITY	Low frequency of CD4 + CD25 + Treg in SLE patients : a heritable trait associated with CTLA4 and TGFbeta gene variants .
18780601	0	CTLA4	40,45	CT60	15,19	CTLA4	CT60	1493	348120	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	Association of CT60 polymorphism of the CTLA4 gene with Graves ' _ disease in Taiwanese children .
18523152	0	CTLA4	0,5	FoxP3	23,28	CTLA4	FoxP3	1493	50943	Gene	Gene	blockade|compound|START_ENTITY expands|nsubj|blockade expands|dobj|regulatory regulatory|amod|END_ENTITY	CTLA4 blockade expands FoxP3 + regulatory and activated effector CD4 + T cells in a dose-dependent fashion .
18641318	0	CTLA4	0,5	FoxP3	68,73	CTLA4	FoxP3	1493	50943	Gene	Gene	expression|compound|START_ENTITY indicator|nsubj|expression indicator|nmod|homeostasis homeostasis|compound|END_ENTITY	CTLA4 expression is an indicator and regulator of steady-state CD4 + FoxP3 + T cell homeostasis .
21937704	0	CTLA4	48,53	FoxP3	35,40	CTLA4	FoxP3	1493	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD147 -LRB- Basigin/Emmprin -RRB- identifies FoxP3 + CD45RO + CTLA4 + - activated human regulatory T cells .
20488788	0	CTLA4	141,146	Foxp3	105,110	CTLA4	Foxp3	12477(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23 / Th17 axis and induction of Foxp3 + regulatory T cells involving CTLA4 signaling in a psoriasis-like skin_disorder .
11976786	0	CTLA4	63,68	cytotoxic_T-lymphocyte_antigen_4	28,60	CTLA4	cytotoxic T-lymphocyte antigen 4	1493	1493	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism in the human cytotoxic_T-lymphocyte_antigen_4 -LRB- CTLA4 -RRB- gene -LRB- exon 1 +49 -RRB- alters T-cell activation .
10023666	0	CTNNA1	25,31	alphaE-catenin	4,18	CTNNA1	alphaE-catenin	1495	1495	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The alphaE-catenin gene -LRB- CTNNA1 -RRB- acts as an invasion-suppressor gene in human colon_cancer cells .
19187332	0	CTNNA3	17,23	Alpha-T-catenin	0,15	CTNNA3	Alpha-T-catenin	29119	29119	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alpha-T-catenin -LRB- CTNNA3 -RRB- gene was identified as a risk variant for toluene_diisocyanate-induced asthma by genome-wide association analysis .
26121339	0	CTNNB1	35,41	KRAS	44,48	CTNNB1	KRAS	1499	3845	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Correction : Selective Targeting of CTNNB1 - , KRAS - or MYC-Driven Cell Growth by Combinations of Existing Drugs .
23442321	0	CTNNB1	114,120	b-catenin	103,112	CTNNB1	b-catenin	1499	1499	Gene	Gene	status|appos|START_ENTITY status|compound|END_ENTITY	Prospective analysis of body mass index , physical activity , and colorectal_cancer risk associated with b-catenin -LRB- CTNNB1 -RRB- status .
10671680	0	CTNNB1	27,33	beta-catenin	35,47	CTNNB1	beta-catenin	1499	1499	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the CTNNB1 -LRB- beta-catenin -RRB- gene in human endometrial_cancer : frequent mutations at codon 34 that cause nuclear accumulation .
15609344	0	CTNNB1	14,20	beta-catenin	0,12	CTNNB1	beta-catenin	1499	1499	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	beta-catenin -LRB- CTNNB1 -RRB- gene amplification : a new mechanism of protein overexpression in cancer .
18832571	0	CTNNB1	45,51	beta-catenin	26,38	CTNNB1	beta-catenin	1499	1499	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Specific mutations in the beta-catenin gene -LRB- CTNNB1 -RRB- correlate with local recurrence in sporadic_desmoid_tumors .
7736793	0	CTNNB1	43,49	beta-catenin	24,36	CTNNB1	beta-catenin	1499	1499	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human beta-catenin gene -LRB- CTNNB1 -RRB- to 3p22 -- > p21 .3 by fluorescence in situ hybridization .
7829088	0	CTNNB1	45,51	beta-catenin	26,38	CTNNB1	beta-catenin	1499	1499	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human beta-catenin gene -LRB- CTNNB1 -RRB- to 3p21 : a region implicated in tumor development .
8838805	0	CTNNB1	53,59	beta-catenin	34,46	CTNNB1	beta-catenin	1499	1499	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the human beta-catenin gene -LRB- CTNNB1 -RRB- .
26130721	0	CTNNBL1	0,7	CWC15	39,44	CTNNBL1	CWC15	56259	51503	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|association association|nmod|END_ENTITY	CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex .
9653641	0	CTNND1	53,59	p120ctn	31,38	CTNND1	p120ctn	1500	1500	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of the human p120ctn catenin gene -LRB- CTNND1 -RRB- : expression of multiple alternatively spliced isoforms .
21106062	0	CTNND2	98,104	catenin	89,96	CTNND2	catenin	1501	31151(Tax:7227)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human homolog of Drosophila Hairy_and_enhancer_of_split_1 , Hes1 , negatively regulates - catenin -LRB- CTNND2 -RRB- expression in cooperation with E2F1 in prostate_cancer .
1783378	0	CTPS	84,88	CTP_synthetase	63,77	CTPS	CTP synthetase	1503	1503	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and chromosomal localization of the human CTP_synthetase gene -LRB- CTPS -RRB- .
1783378	0	CTP_synthetase	63,77	CTPS	84,88	CTP synthetase	CTPS	1503	1503	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and chromosomal localization of the human CTP_synthetase gene -LRB- CTPS -RRB- .
23132950	0	CTR1	0,4	EIN2	42,46	CTR1	EIN2	831748(Tax:3702)	831889(Tax:3702)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis .
24967972	0	CTR1	71,75	IRS-4	101,106	CTR1	IRS-4	1317	8471	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4 .
22445756	0	CTR2	32,36	Mac1p	89,94	CTR2	Mac1p	856580(Tax:4932)	855035(Tax:4932)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Low-affinity copper transporter CTR2 is regulated by copper-sensing transcription factor Mac1p in Saccharomyces_cerevisiae .
22683637	0	CTR2	102,106	Mac1p	36,41	CTR2	Mac1p	856580(Tax:4932)	855035(Tax:4932)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|factors factors|dep|END_ENTITY	Metal-sensing transcription factors Mac1p and Aft1p coordinately regulate vacuolar copper transporter CTR2 in Saccharomyces_cerevisiae .
22580415	0	CTRC	43,47	chymotrypsin_C	27,41	CTRC	chymotrypsin C	11330	11330	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comprehensive screening of chymotrypsin_C -LRB- CTRC -RRB- gene in tropical_calcific_pancreatitis identifies novel variants .
16806199	0	CTRP1	60,65	Tumor_necrosis_factor-alpha	0,27	CTRP1	Tumor necrosis factor-alpha	303701(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Tumor_necrosis_factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue .
17122143	0	CTRP5	65,70	MFRP	35,39	CTRP5	MFRP	235312(Tax:10090)	259172(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Spatial and temporal expression of MFRP and its interaction with CTRP5 .
9745020	0	CTS1	22,26	chitinase	28,37	CTS1	chitinase	850992(Tax:4932)	850992(Tax:4932)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Ace2p , a regulator of CTS1 -LRB- chitinase -RRB- expression , affects pseudohyphal production in Saccharomyces_cerevisiae .
1577456	0	CTSB	44,48	cathepsin_B	26,37	CTSB	cathepsin B	1508	1508	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Confirmation of the human cathepsin_B gene -LRB- CTSB -RRB- assignment to chromosome 8 .
12112662	0	CTSC	61,65	cathepsin_c	43,54	CTSC	cathepsin c	1075	1075	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Biochemical and mutational analyses of the cathepsin_c gene -LRB- CTSC -RRB- in three North American families with Papillon_Lef __ vre_syndrome .
24440757	0	CTSC	69,73	miR-23a	39,46	CTSC	miR-23a	1075	407010	Gene	Gene	expression|compound|START_ENTITY expression|appos|expression expression|amod|END_ENTITY	All-trans_retinoic_acid -LRB- ATRA -RRB- induces miR-23a expression , decreases CTSC expression and granzyme_B activity leading to impaired NK cell cytotoxicity .
16386934	0	CTSD	36,40	cathepsin_D	18,29	CTSD	cathepsin D	483662(Tax:9615)	483662(Tax:9615)	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	A mutation in the cathepsin_D gene -LRB- CTSD -RRB- in American Bulldogs with neuronal_ceroid_lipofuscinosis .
18607787	0	CTSD	90,94	cathepsin_D	77,88	CTSD	cathepsin D	494568(Tax:9823)	494568(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence identification , tissue distribution and polymorphism of the porcine cathepsin_D -LRB- CTSD -RRB- gene .
19662513	0	CTSK	61,65	cathepsin_K	48,59	CTSK	cathepsin K	397569(Tax:9823)	397569(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A single nucleotide polymorphism in the porcine cathepsin_K -LRB- CTSK -RRB- gene is associated with back fat thickness and production traits in Italian Duroc pigs .
20305575	0	CTSK	42,46	cathepsin_K	29,40	CTSK	cathepsin K	1513	1513	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel missense mutation in cathepsin_K -LRB- CTSK -RRB- gene in a consanguineous Pakistani family with pycnodysostosis .
21099701	0	CTSK	68,72	cathepsin_K	79,90	CTSK	cathepsin K	1513	1513	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Familial_pycnodysostosis : identification of a novel mutation in the CTSK gene -LRB- cathepsin_K -RRB- .
9143491	0	CTSK	80,84	cathepsin_K	62,73	CTSK	cathepsin K	1513	1513	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and chromosome localization of the human cathepsin_K gene -LRB- CTSK -RRB- .
22871890	0	CTSL1	80,85	cathepsin_L	67,78	CTSL1	cathepsin L	1514	1514	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Genes and environment : novel , functional polymorphism in the human cathepsin_L -LRB- CTSL1 -RRB- promoter disrupts a xenobiotic response element -LRB- XRE -RRB- to alter transcription and blood pressure .
23542171	0	CTSL2	0,5	E2F1	35,39	CTSL2	E2F1	1515	1869	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis .
17869649	0	CTSL2	35,40	cathepsin_L2	21,33	CTSL2	cathepsin L2	1515	1515	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the cathepsin_L2 -LRB- CTSL2 -RRB- gene show association with type 1 diabetes and early-onset myasthenia_gravis .
9790772	0	CTSO	78,82	cathepsin_O	60,71	CTSO	cathepsin O	1519	1519	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure and chromosomal localization of the human cathepsin_O gene -LRB- CTSO -RRB- .
10721671	0	CTSS	24,28	cathepsin_S	6,17	CTSS	cathepsin S	1520	1520	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human cathepsin_S gene -LRB- CTSS -RRB- promoter -25 G/A polymorphism .
1848176	0	CTT1	81,85	catalase_T	69,79	CTT1	catalase T	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Negative regulation of transcription of the Saccharomyces_cerevisiae catalase_T -LRB- CTT1 -RRB- gene by cAMP is mediated by a positive control element .
2061315	0	CTT1	67,71	catalase_T	100,110	CTT1	catalase T	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	Heat_shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase_T of Saccharomyces_cerevisiae .
2844525	0	CTT1	177,181	catalase_T	160,170	CTT1	catalase T	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins : a binding site for the HAP1 -LRB- CYP1 -RRB- protein in the UAS region of the yeast catalase_T gene -LRB- CTT1 -RRB- .
8987534	0	CTT1	136,140	catalase_T	124,134	CTT1	catalase T	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Recombinant Hansenula_polymorpha as a biocatalyst : coexpression of the spinach glycolate oxidase -LRB- GO -RRB- and the S. _ cerevisiae catalase_T -LRB- CTT1 -RRB- gene .
21418910	0	CTTN	32,36	cortactin	19,28	CTTN	cortactin	2017	2017	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	-LSB- A pivotal role of cortactin , a CTTN encoding protein , in endocytosis of human colon_cancer -RSB- .
22170571	0	CTX-M-1	42,49	bla	36,39	CTX-M-1	bla	13909205	3244915(Tax:562)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Complex class 1 integron containing bla -LRB- CTX-M-1 -RRB- genes isolated from Escherichia_coli : a potentially novel resistant gene-capturing tool kit .
21220330	0	CUB-domain-containing_protein_1	0,31	Src	50,53	CUB-domain-containing protein 1	Src	64866	6714	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CUB-domain-containing_protein_1 -LRB- CDCP1 -RRB- activates Src to promote melanoma metastasis .
23390341	0	CUBN	34,38	cubilin	25,32	CUBN	cubilin	8029	8029	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phylogenetic analysis of cubilin -LRB- CUBN -RRB- gene .
25876044	0	CUB_Domain-Containing_Protein-1	46,77	SHP2	25,29	CUB Domain-Containing Protein-1	SHP2	64866	5781	Gene	Gene	Associates|nmod|START_ENTITY Associates|compound|END_ENTITY	The Tyrosine Phosphatase SHP2 Associates with CUB_Domain-Containing_Protein-1 -LRB- CDCP1 -RRB- , Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner .
25876044	0	CUB_Domain-Containing_Protein-1	46,77	SHP2	25,29	CUB Domain-Containing Protein-1	SHP2	64866	5781	Gene	Gene	Associates|nmod|START_ENTITY Associates|compound|END_ENTITY	The Tyrosine Phosphatase SHP2 Associates with CUB_Domain-Containing_Protein-1 -LRB- CDCP1 -RRB- , Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner .
19077003	0	CUB_domain_containing_protein	14,43	CDCP1	45,50	CUB domain containing protein	CDCP1	64866	64866	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CUB_domain_containing_protein -LRB- CDCP1 -RRB- is correlated with prognosis and survival of patients with adenocarcinoma_of_lung .
17335815	0	CUB_domain_containing_protein_1	18,49	CDCP1	51,56	CUB domain containing protein 1	CDCP1	64866	64866	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the CUB_domain_containing_protein_1 -LRB- CDCP1 -RRB- gene in colorectal_tumour cells .
26347501	0	CUDR	19,23	HULC	34,38	CUDR	HULC	652995	728655	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Long noncoding RNA CUDR regulates HULC and b-Catenin to govern human liver stem cell malignant differentiation .
26347501	0	CUDR	19,23	HULC	34,38	CUDR	HULC	652995	728655	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Long noncoding RNA CUDR regulates HULC and b-Catenin to govern human liver stem cell malignant differentiation .
26581161	0	CUDR	22,26	SET1A	0,5	CUDR	SET1A	652995	9739	Gene	Gene	Cooperates|nmod|START_ENTITY Cooperates|compound|END_ENTITY	SET1A Cooperates With CUDR to Promote Liver_Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation Epigenetically .
26816536	0	CUG-binding_protein_1	0,21	CUGBP1	23,29	CUG-binding protein 1	CUGBP1	10658	10658	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CUG-binding_protein_1 -LRB- CUGBP1 -RRB- expression and prognosis of brain metastases from non-small_cell_lung_cancer .
22072795	0	CUG-binding_protein_1	18,39	miR-503	0,7	CUG-binding protein 1	miR-503	10658	574506	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	miR-503 represses CUG-binding_protein_1 translation by recruiting CUGBP1 mRNA to processing bodies .
26816536	0	CUGBP1	23,29	CUG-binding_protein_1	0,21	CUGBP1	CUG-binding protein 1	10658	10658	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CUG-binding_protein_1 -LRB- CUGBP1 -RRB- expression and prognosis of brain metastases from non-small_cell_lung_cancer .
21637851	0	CUGBP1	74,80	p21	0,3	CUGBP1	p21	10658	1026	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis .
18292181	0	CUGBP2	111,117	Mcl-1	63,68	CUGBP2	Mcl-1	10659	4170	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Translation inhibition during cell cycle arrest and apoptosis : Mcl-1 is a novel target for RNA binding protein CUGBP2 .
15099703	0	CUG_binding_protein_1	22,43	myotonic_dystrophy_1	52,72	CUG binding protein 1	myotonic dystrophy 1	10658	1760	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Altered expression of CUG_binding_protein_1 mRNA in myotonic_dystrophy_1 : possible RNA-RNA interaction .
9663463	0	CUL-1	6,11	SKP1	77,81	CUL-1	SKP1	8454	6500	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human CUL-1 , but not other cullin family members , selectively interacts with SKP1 to form a complex with SKP2 and cyclin_A .
17145765	0	CUL-4	97,102	DDB-1	103,108	CUL-4	DDB-1	174198(Tax:6239)	178156(Tax:6239)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The Caenorhabditis_elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4 / DDB-1 complex .
12504025	0	CUL1	22,26	CAND1	44,49	CUL1	CAND1	8454	55832	Gene	Gene	modification|nmod|START_ENTITY dissociates|nsubj|modification dissociates|dobj|p120 p120|appos|END_ENTITY	NEDD8 modification of CUL1 dissociates p120 -LRB- CAND1 -RRB- , an inhibitor of CUL1-SKP1 binding and SCF ligases .
12504026	0	CUL1	28,32	CAND1	0,5	CUL1	CAND1	8454	55832	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex .
16036220	0	CUL1	32,36	CAND1	0,5	CUL1	CAND1	8454	55832	Gene	Gene	deneddylation|nmod|START_ENTITY enhances|dobj|deneddylation enhances|nsubj|END_ENTITY	CAND1 enhances deneddylation of CUL1 by COP9 signalosome .
10441001	0	CUL2	141,145	von_Hippel-Lindau	89,106	CUL2	von Hippel-Lindau	8453	7428	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Genomic organization and chromosomal localization of the human CUL2 gene and the role of von_Hippel-Lindau tumor suppressor-binding protein -LRB- CUL2 and VBP1 -RRB- mutation and loss in renal-cell_carcinoma development .
12481031	0	CUL7	0,4	cullin	30,36	CUL7	cullin	9820	143384	Gene	Gene	START_ENTITY|parataxis|binds binds|nsubj|END_ENTITY	CUL7 : A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex .
22609398	0	CUP1	98,102	Ace1p	83,88	CUP1	Ace1p	856450(Tax:4932)	852710(Tax:4932)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Chromatin repositioning activity and transcription machinery are both recruited by Ace1p in yeast CUP1 activation .
9710584	0	CUS2	0,4	Tat-SF1	31,38	CUS2	Tat-SF1	855430(Tax:4932)	27336	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	CUS2 , a yeast homolog of human Tat-SF1 , rescues function of misfolded U2 through an unusual RNA recognition motif .
12788532	0	CUSP	4,8	p63	41,44	CUSP	p63	8626	8626	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation .
17227781	0	CUTL1	17,22	WNT5A	0,5	CUTL1	WNT5A	1523	7474	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	WNT5A -- target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic_cancer .
20945532	0	CUX1	120,124	CCAAT-Displacement-protein	92,118	CUX1	CCAAT-Displacement-protein	1523	1523	Gene	Gene	repressor|appos|START_ENTITY repressor|amod|END_ENTITY	The Promyelocytic_Leukemia Zinc Finger -LRB- PLZF -RRB- gene is a novel transcriptional target of the CCAAT-Displacement-protein -LRB- CUX1 -RRB- repressor .
20689760	0	CUX1	36,40	GRIA3	19,24	CUX1	GRIA3	1523	2892	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Glutamate receptor GRIA3 -- target of CUX1 and mediator of tumor progression in pancreatic_cancer .
19635798	0	CUX1	5,9	p110	0,4	CUX1	p110	1523	1523	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin .
19738070	0	CUX1	39,43	p110	34,38	CUX1	CUX1	13047(Tax:10090)	13047(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|amod|END_ENTITY	Mouse_mammary_tumor_virus p75 and p110 CUX1 transgenic_mice develop mammary_tumors of various histologic types .
23590133	0	CUX1	50,54	p110	45,49	CUX1	p110	1523	1523	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array .
3025487	0	CV-3317	47,54	angiotensin_converting_enzyme	14,43	CV-3317	angiotensin converting enzyme	2549020(Tax:243365)	24310(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_converting_enzyme by CV-3317 , a non-sulfhydryl compound .
26130721	0	CWC15	39,44	CTNNBL1	0,7	CWC15	CTNNBL1	51503	56259	Gene	Gene	association|nmod|START_ENTITY facilitates|dobj|association facilitates|nsubj|END_ENTITY	CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex .
19389360	0	CWN-1	0,5	DSH-2	21,26	CWN-1	DSH-2	173399(Tax:6239)	266854(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	CWN-1 functions with DSH-2 to regulate C. _ elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway .
23073770	0	CX26	20,24	GJB2	14,18	CX26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prevalence of GJB2 -LRB- CX26 -RRB- gene mutations in south Iranian patients with autosomal_recessive_nonsyndromic_sensorineural_hearing_loss .
12363395	0	CX36	45,49	connexin_36	27,38	CX36	connexin 36	57369	57369	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of the connexin_36 gene -LRB- CX36 -RRB- and exclusion of the coding sequence as a candidate region for catatonic_schizophrenia in a large pedigree .
11870871	0	CX3CL1	27,33	CX3CR1	53,59	CX3CL1	CX3CR1	6376	1524	Gene	Gene	fractalkine|appos|START_ENTITY Expression|nmod|fractalkine END_ENTITY|nsubj|Expression	Expression of fractalkine -LRB- CX3CL1 -RRB- and its receptor , CX3CR1 , during acute_and_chronic_inflammation in the rodent CNS .
15361546	0	CX3CL1	58,64	CX3CR1	149,155	CX3CL1	CX3CR1	6376	1524	Gene	Gene	protein-II|appos|START_ENTITY chimeras|nsubj|protein-II chimeras|xcomp|identify identify|dobj|determinants determinants|nmod|affinity affinity|nmod|END_ENTITY	Viral macrophage inflammatory protein-II and fractalkine -LRB- CX3CL1 -RRB- chimeras identify molecular determinants of affinity , efficacy , and selectivity at CX3CR1 .
15974917	0	CX3CL1	21,27	CX3CR1	101,107	CX3CL1	CX3CR1	6376	1524	Gene	Gene	fractalkine|appos|START_ENTITY Role|nmod|fractalkine Role|dep|development development|nmod|antagonists antagonists|compound|END_ENTITY	Role of fractalkine -LRB- CX3CL1 -RRB- in regulating neuron-microglia interactions : development of viral-based CX3CR1 antagonists .
17611763	0	CX3CL1	77,83	CX3CR1	38,44	CX3CL1	CX3CR1	6376	1524	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms of Fractalkine_receptor CX3CR1 and plasma levels of its ligand CX3CL1 in colorectal_cancer patients .
18508133	0	CX3CL1	0,6	CX3CR1	55,61	CX3CL1	CX3CR1	20312(Tax:10090)	13051(Tax:10090)	Gene	Gene	murine|nsubj|START_ENTITY murine|parataxis|impact impact|nsubj|deficiency deficiency|compound|END_ENTITY	CX3CL1 and CX3CR1 in the GL261 murine model of glioma : CX3CR1 deficiency does not impact tumor growth or infiltration of microglia and lymphocytes .
18772344	0	CX3CL1	0,6	CX3CR1	55,61	CX3CL1	CX3CR1	6376	1524	Gene	Gene	up-regulation|compound|START_ENTITY associated|nsubjpass|up-regulation associated|nmod|recruitment recruitment|nmod|phagocytes phagocytes|compound|END_ENTITY	CX3CL1 up-regulation is associated with recruitment of CX3CR1 + mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema .
20041188	0	CX3CL1	68,74	CX3CR1	0,6	CX3CL1	CX3CR1	6376	1524	Gene	Gene	corrected|dobj|START_ENTITY lymphocytes|acl|corrected expressed|nmod|lymphocytes expressed|nsubjpass|END_ENTITY	CX3CR1 is expressed by human B lymphocytes and mediates -LSB- corrected -RSB- CX3CL1 driven chemotaxis of tonsil centrocytes .
23414540	0	CX3CL1	26,32	CX3CR1	75,81	CX3CL1	CX3CR1	6376	1524	Gene	Gene	cooperation|nmod|START_ENTITY cooperation|nmod|END_ENTITY	Novel cooperation between CX3CL1 and CCL26 inducing NK cell chemotaxis via CX3CR1 : a possible mechanism for NK cell infiltration of the allergic nasal tissue .
23829599	0	CX3CL1	14,20	CX3CR1	39,45	CX3CL1	CX3CL1	6376	89808(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CX3CL1 and its receptor , CX3CR1 , in the development of periapical_lesions .
24060055	0	CX3CL1	124,130	CX3CR1	132,138	CX3CL1	CX3CR1	6376	1524	Gene	Gene	fractalkine|appos|START_ENTITY expression|nmod|fractalkine associated|nmod|expression Hypertrophy|acl|associated Hypertrophy|parataxis|chemokine chemokine|nsubj|END_ENTITY	Hypertrophy of the ligament flavum in degenerative_lumbar_stenosis associated with the increased expression of fractalkine -LRB- CX3CL1 -RRB- / CX3CR1 chemokine .
24175290	0	CX3CL1	36,42	CX3CR1	70,76	CX3CL1	CX3CR1	6376	1524	Gene	Gene	fractalkine|appos|START_ENTITY fractalkine|appos|END_ENTITY	Elevated expression of fractalkine -LRB- CX3CL1 -RRB- and fractalkine_receptor -LRB- CX3CR1 -RRB- in the dorsal root ganglia and spinal cord in experimental_autoimmune_encephalomyelitis : implications in multiple_sclerosis-induced neuropathic_pain .
24270813	0	CX3CL1	0,6	CX3CR1	143,149	CX3CL1	CX3CR1	6376	1524	Gene	Gene	START_ENTITY|dep|importance importance|nmod|signaling signaling|compound|END_ENTITY	CX3CL1 -LRB- fractalkine -RRB- and TNFa production by perfused human placental lobules under normoxic and hypoxic conditions in vitro : the importance of CX3CR1 signaling .
25420917	0	CX3CL1	19,25	CX3CR1	40,46	CX3CL1	CX3CR1	6376	1524	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|pathway pathway|nummod|END_ENTITY	Involvement of the CX3CL1 -LRB- fractalkine -RRB- / CX3CR1 pathway in the pathogenesis of acute_graft-versus-host_disease .
25926643	0	CX3CL1	27,33	CX3CR1	107,113	CX3CL1	CX3CR1	6376	1524	Gene	Gene	expression|nmod|START_ENTITY affect|nsubj|expression affect|dobj|migration-activity migration-activity|nmod|cells cells|nummod|END_ENTITY	Differential expression of CX3CL1 in HBV-replicating hepatoma cells could affect the migration-activity of CX3CR1 + immune cells .
25962684	0	CX3CL1	18,24	CX3CR1	64,70	CX3CL1	CX3CR1	6376	1524	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|multiple_myeloma multiple_myeloma|nmod|END_ENTITY	Role of chemokine CX3CL1 in progression of multiple_myeloma via CX3CR1 in bone microenvironments .
22177089	0	CX3CL1	13,19	Fractalkine	0,11	CX3CL1	Fractalkine	6376	6376	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Fractalkine -LRB- CX3CL1 -RRB- levels in patients with Beh et 's disease and neuro-Beh et 's disease .
26586708	0	CX3CL1	25,31	Fractalkine	32,43	CX3CL1	Fractalkine	6376	6376	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Elevated Local and Serum CX3CL1 -LRB- Fractalkine -RRB- Expression and Its Association with Disease Severity in Patients with Psoriasis .
25375377	0	CX3CL1	71,77	IFN-y	0,5	CX3CL1	IFN-y	20312(Tax:10090)	3458	Gene	Gene	regulating|dobj|START_ENTITY induces|advcl|regulating induces|nsubj|END_ENTITY	IFN-y induces aberrant CD49b NK cell recruitment through regulating CX3CL1 : a novel mechanism by which IFN-y provokes pregnancy failure .
16148119	0	CX3CL1	54,60	Syk	0,3	CX3CL1	Syk	6376	6850	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Syk is required for monocyte/macrophage chemotaxis to CX3CL1 -LRB- Fractalkine -RRB- .
20231691	0	CX3CL1	192,198	TNF-alpha	144,153	CX3CL1	TNF-alpha	6376	7124	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Characterization of synergistic induction of CX3CL1/fractalkine by TNF-alpha and IFN-gamma in vascular endothelial cells : an essential role for TNF-alpha in post-transcriptional regulation of CX3CL1 .
12667665	0	CX3CL1	45,51	fractalkine	32,43	CX3CL1	fractalkine	6376	6376	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	CSF and serum levels of soluble fractalkine -LRB- CX3CL1 -RRB- in inflammatory_diseases_of_the_nervous_system .
12966591	0	CX3CL1	37,43	fractalkine	24,35	CX3CL1	fractalkine	6376	6376	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Proinflammatory role of fractalkine -LRB- CX3CL1 -RRB- in rheumatoid_arthritis .
15013759	0	CX3CL1	55,61	fractalkine	42,53	CX3CL1	fractalkine	6376	6376	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	TNF-alpha and IL-4 regulate expression of fractalkine -LRB- CX3CL1 -RRB- as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts .
23143793	0	CX3CL1	30,36	fractalkine	17,28	CX3CL1	fractalkine	6376	6376	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of fractalkine -LRB- CX3CL1 -RRB- in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium .
23261412	0	CX3CL1	127,133	fractalkine	114,125	CX3CL1	fractalkine	6376	6376	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine -LRB- CX3CL1 -RRB- levels in a large UK twins ' sample .
19915801	0	CX3CR1	28,34	Angiotensin_II	0,14	CX3CR1	Angiotensin II	1524	183	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Angiotensin_II up-regulates CX3CR1 expression in THP-1 monocytes : impact on vascular_inflammation and atherogenesis .
22403256	0	CX3CR1	99,105	CD11b	106,111	CX3CR1	CD11b	13051(Tax:10090)	16409(Tax:10090)	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1 + CD11b + F4/80 + regulatory macrophages in mice .
24711412	0	CX3CR1	26,32	CD11c	19,24	CX3CR1	CD11c	1524	3687	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Differentiation of CD11c + CX3CR1 + cells in the small intestine requires Notch signaling .
25830914	0	CX3CR1	110,116	CD16	105,109	CX3CR1	CD16	1524	2214	Gene	Gene	Monocytes|compound|START_ENTITY Monocytes|compound|END_ENTITY	Transcriptome Analysis in Patients with Chronic_Kidney_Disease on Hemodialysis Disclosing a Key Role for CD16 + CX3CR1 + Monocytes .
15871132	0	CX3CR1	25,31	CD4	95,98	CX3CR1	CD4	1524	920	Gene	Gene	polymorphisms|nmod|START_ENTITY predict|nsubj|polymorphisms predict|dobj|progression progression|nmod|children children|nmod|count count|amod|lymphocyte lymphocyte|nmod:npmod|+ +|nummod|END_ENTITY	Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4 + lymphocyte count and HIV-1 RNA load .
17804530	0	CX3CR1	44,50	CD4	55,58	CX3CR1	CD4	1524	920	Gene	Gene	fractalkine_receptor|appos|START_ENTITY expression|nmod|fractalkine_receptor expression|nmod|+ +|compound|END_ENTITY	Surface expression of fractalkine_receptor -LRB- CX3CR1 -RRB- on CD4 + / CD28 T cells in RA patients and correlation with atherosclerotic_damage .
22313962	0	CX3CR1	40,46	CD4	36,39	CX3CR1	CD4	1524	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A role for cytomegalovirus-specific CD4 + CX3CR1 + T cells and cytomegalovirus-induced T-cell immunopathology in HIV-associated atherosclerosis .
26195744	0	CX3CR1	48,54	CD4	66,69	CX3CR1	CD4	1524	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	Dengue_virus_infection elicits highly polarized CX3CR1 + cytotoxic CD4 + T cells associated with protective immunity .
26195744	0	CX3CR1	48,54	CD4	66,69	CX3CR1	CD4	1524	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	Dengue_virus_infection elicits highly polarized CX3CR1 + cytotoxic CD4 + T cells associated with protective immunity .
11870871	0	CX3CR1	53,59	CX3CL1	27,33	CX3CR1	CX3CL1	1524	6376	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|fractalkine fractalkine|appos|END_ENTITY	Expression of fractalkine -LRB- CX3CL1 -RRB- and its receptor , CX3CR1 , during acute_and_chronic_inflammation in the rodent CNS .
15361546	0	CX3CR1	149,155	CX3CL1	58,64	CX3CR1	CX3CL1	1524	6376	Gene	Gene	affinity|nmod|START_ENTITY determinants|nmod|affinity identify|dobj|determinants chimeras|xcomp|identify chimeras|nsubj|protein-II protein-II|appos|END_ENTITY	Viral macrophage inflammatory protein-II and fractalkine -LRB- CX3CL1 -RRB- chimeras identify molecular determinants of affinity , efficacy , and selectivity at CX3CR1 .
15974917	0	CX3CR1	101,107	CX3CL1	21,27	CX3CR1	CX3CL1	1524	6376	Gene	Gene	antagonists|compound|START_ENTITY development|nmod|antagonists Role|dep|development Role|nmod|fractalkine fractalkine|appos|END_ENTITY	Role of fractalkine -LRB- CX3CL1 -RRB- in regulating neuron-microglia interactions : development of viral-based CX3CR1 antagonists .
17611763	0	CX3CR1	38,44	CX3CL1	77,83	CX3CR1	CX3CL1	1524	6376	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms of Fractalkine_receptor CX3CR1 and plasma levels of its ligand CX3CL1 in colorectal_cancer patients .
18508133	0	CX3CR1	55,61	CX3CL1	0,6	CX3CR1	CX3CL1	13051(Tax:10090)	20312(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY impact|nsubj|deficiency murine|parataxis|impact murine|nsubj|END_ENTITY	CX3CL1 and CX3CR1 in the GL261 murine model of glioma : CX3CR1 deficiency does not impact tumor growth or infiltration of microglia and lymphocytes .
18772344	0	CX3CR1	55,61	CX3CL1	0,6	CX3CR1	CX3CL1	1524	6376	Gene	Gene	phagocytes|compound|START_ENTITY recruitment|nmod|phagocytes associated|nmod|recruitment associated|nsubjpass|up-regulation up-regulation|compound|END_ENTITY	CX3CL1 up-regulation is associated with recruitment of CX3CR1 + mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema .
20041188	0	CX3CR1	0,6	CX3CL1	68,74	CX3CR1	CX3CL1	1524	6376	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|lymphocytes lymphocytes|acl|corrected corrected|dobj|END_ENTITY	CX3CR1 is expressed by human B lymphocytes and mediates -LSB- corrected -RSB- CX3CL1 driven chemotaxis of tonsil centrocytes .
23414540	0	CX3CR1	75,81	CX3CL1	26,32	CX3CR1	CX3CL1	1524	6376	Gene	Gene	cooperation|nmod|START_ENTITY cooperation|nmod|END_ENTITY	Novel cooperation between CX3CL1 and CCL26 inducing NK cell chemotaxis via CX3CR1 : a possible mechanism for NK cell infiltration of the allergic nasal tissue .
23829599	0	CX3CR1	39,45	CX3CL1	14,20	CX3CL1	CX3CL1	89808(Tax:10116)	6376	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CX3CL1 and its receptor , CX3CR1 , in the development of periapical_lesions .
24060055	0	CX3CR1	132,138	CX3CL1	124,130	CX3CR1	CX3CL1	1524	6376	Gene	Gene	chemokine|nsubj|START_ENTITY Hypertrophy|parataxis|chemokine Hypertrophy|acl|associated associated|nmod|expression expression|nmod|fractalkine fractalkine|appos|END_ENTITY	Hypertrophy of the ligament flavum in degenerative_lumbar_stenosis associated with the increased expression of fractalkine -LRB- CX3CL1 -RRB- / CX3CR1 chemokine .
24175290	0	CX3CR1	70,76	CX3CL1	36,42	CX3CR1	CX3CL1	1524	6376	Gene	Gene	fractalkine|appos|START_ENTITY fractalkine|appos|END_ENTITY	Elevated expression of fractalkine -LRB- CX3CL1 -RRB- and fractalkine_receptor -LRB- CX3CR1 -RRB- in the dorsal root ganglia and spinal cord in experimental_autoimmune_encephalomyelitis : implications in multiple_sclerosis-induced neuropathic_pain .
24270813	0	CX3CR1	143,149	CX3CL1	0,6	CX3CR1	CX3CL1	1524	6376	Gene	Gene	signaling|compound|START_ENTITY importance|nmod|signaling END_ENTITY|dep|importance	CX3CL1 -LRB- fractalkine -RRB- and TNFa production by perfused human placental lobules under normoxic and hypoxic conditions in vitro : the importance of CX3CR1 signaling .
25420917	0	CX3CR1	40,46	CX3CL1	19,25	CX3CR1	CX3CL1	1524	6376	Gene	Gene	pathway|nummod|START_ENTITY Involvement|dep|pathway Involvement|nmod|END_ENTITY	Involvement of the CX3CL1 -LRB- fractalkine -RRB- / CX3CR1 pathway in the pathogenesis of acute_graft-versus-host_disease .
25926643	0	CX3CR1	107,113	CX3CL1	27,33	CX3CR1	CX3CL1	1524	6376	Gene	Gene	cells|nummod|START_ENTITY migration-activity|nmod|cells affect|dobj|migration-activity affect|nsubj|expression expression|nmod|END_ENTITY	Differential expression of CX3CL1 in HBV-replicating hepatoma cells could affect the migration-activity of CX3CR1 + immune cells .
25962684	0	CX3CR1	64,70	CX3CL1	18,24	CX3CR1	CX3CL1	1524	6376	Gene	Gene	multiple_myeloma|nmod|START_ENTITY Role|nmod|multiple_myeloma Role|nmod|END_ENTITY	Role of chemokine CX3CL1 in progression of multiple_myeloma via CX3CR1 in bone microenvironments .
22403256	0	CX3CR1	99,105	F4/80	112,117	CX3CR1	F4/80	13051(Tax:10090)	13733(Tax:10090)	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1 + CD11b + F4/80 + regulatory macrophages in mice .
17885215	0	CX3CR1	87,93	Fractalkine	0,11	CX3CR1	Fractalkine	1524	6376	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|nsubj|END_ENTITY	Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway .
18003857	0	CX3CR1	22,28	Fractalkine_receptor	0,20	CX3CR1	Fractalkine receptor	13051(Tax:10090)	13051(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Fractalkine_receptor -LRB- CX3CR1 -RRB- inhibition is protective against ischemic acute_renal_failure in mice .
25221380	0	CX3CR1	46,52	Fractalkine_receptor	25,45	CX3CR1	Fractalkine receptor	1524	1524	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Two polymorphisms in the Fractalkine_receptor CX3CR1 gene influence the development of atherosclerosis : a meta-analysis .
22941344	0	CX3CR1	18,24	HIF-1	40,45	CX3CR1	HIF-1	1524	3091	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Hypoxia increases CX3CR1 expression via HIF-1 and NF - kB in androgen-independent prostate_cancer cells .
19959384	0	CX3CR1	33,39	Interleukin-6	0,13	CX3CR1	Interleukin-6	171056(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve_injury through the activation of p38 MAPK .
12446007	0	CX3CR1	22,28	TGF-beta1	0,9	CX3CR1	TGF-beta1	171056(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia .
19915801	0	CX3CR1	28,34	THP-1	49,54	CX3CR1	THP-1	1524	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|monocytes monocytes|compound|END_ENTITY	Angiotensin_II up-regulates CX3CR1 expression in THP-1 monocytes : impact on vascular_inflammation and atherogenesis .
23086480	0	CX3CR1	110,116	TLR4	131,135	CX3CR1	TLR4	1524	7099	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Inflammatory effects of resistin on human smooth_muscle_cells : up-regulation of fractalkine and its receptor , CX3CR1 expression by TLR4 and Gi-protein pathways .
18941208	0	CX3CR1	0,6	c-kit	8,13	CX3CR1	c-kit	1524	3815	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	CX3CR1 + c-kit + bone marrow cells give rise to CD103 + and CD103 - dendritic cells with distinct functional properties .
22731642	0	CX3CR1	71,77	chemokine_receptor	52,70	CX3CR1	chemokine receptor	1524	7852	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Association of V249I and T280M polymorphisms in the chemokine_receptor CX3CR1 gene with early onset of coronary_artery_disease among North Indians .
11870871	0	CX3CR1	53,59	fractalkine	14,25	CX3CR1	fractalkine	1524	6376	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of fractalkine -LRB- CX3CL1 -RRB- and its receptor , CX3CR1 , during acute_and_chronic_inflammation in the rodent CNS .
12076860	0	CX3CR1	56,62	fractalkine	27,38	CX3CR1	fractalkine	1524	6376	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Up-regulated expression of fractalkine and its receptor CX3CR1 during liver_injury in humans .
15974917	0	CX3CR1	101,107	fractalkine	8,19	CX3CR1	fractalkine	1524	6376	Gene	Gene	antagonists|compound|START_ENTITY development|nmod|antagonists Role|dep|development Role|nmod|END_ENTITY	Role of fractalkine -LRB- CX3CL1 -RRB- in regulating neuron-microglia interactions : development of viral-based CX3CR1 antagonists .
17241867	0	CX3CR1	24,30	fractalkine	76,87	CX3CR1	fractalkine	1524	6376	Gene	Gene	recruitment|nmod|START_ENTITY +|nsubj|recruitment +|nmod|END_ENTITY	Enhanced recruitment of CX3CR1 + T cells by mucosal endothelial cell-derived fractalkine in inflammatory_bowel_disease .
18424766	0	CX3CR1	49,55	fractalkine	28,39	CX3CR1	fractalkine	1524	6376	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|receptor receptor|amod|END_ENTITY	Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression .
20019415	0	CX3CR1	46,52	fractalkine	16,27	CX3CR1	fractalkine	1524	6376	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of fractalkine and its receptor , CX3CR1 , is associated with coronary plaque_rupture in patients with unstable angina_pectoris .
21527754	0	CX3CR1	80,86	fractalkine	102,113	CX3CR1	fractalkine	1524	6376	Gene	Gene	upregulating|dobj|START_ENTITY upregulating|nmod|END_ENTITY	Amyloid beta enhances migration of endothelial progenitor cells by upregulating CX3CR1 in response to fractalkine , which may be associated with development of choroidal_neovascularization .
22648046	0	CX3CR1	53,59	fractalkine	24,35	CX3CR1	fractalkine	485599(Tax:9615)	6376	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Increased expression of fractalkine and its receptor CX3CR1 in canine inflammatory_bowel_disease and their possible role in recruitment of intraepithelial lymphocytes .
23125415	0	CX3CR1	137,143	fractalkine	105,116	CX3CR1	fractalkine	1524	6376	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|mutant mutant|nmod|END_ENTITY	Integrins avb3 and a4b1 act as coreceptors for fractalkine , and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1 .
24060055	0	CX3CR1	132,138	fractalkine	111,122	CX3CR1	fractalkine	1524	6376	Gene	Gene	chemokine|nsubj|START_ENTITY Hypertrophy|parataxis|chemokine Hypertrophy|acl|associated associated|nmod|expression expression|nmod|END_ENTITY	Hypertrophy of the ligament flavum in degenerative_lumbar_stenosis associated with the increased expression of fractalkine -LRB- CX3CL1 -RRB- / CX3CR1 chemokine .
25420917	0	CX3CR1	40,46	fractalkine	27,38	CX3CR1	fractalkine	1524	6376	Gene	Gene	pathway|nummod|START_ENTITY Involvement|dep|pathway Involvement|nmod|CX3CL1 CX3CL1|appos|END_ENTITY	Involvement of the CX3CL1 -LRB- fractalkine -RRB- / CX3CR1 pathway in the pathogenesis of acute_graft-versus-host_disease .
26567742	0	CX3CR1	11,17	fractalkine	140,151	CX3CR1	fractalkine	13051(Tax:10090)	6376	Gene	Gene	chemokines|compound|START_ENTITY Effects|nmod|chemokines Is|dobj|Effects Is|nsubj|END_ENTITY	Effects of CX3CR1 and fractalkine chemokines in amyloid beta clearance and p-Tau accumulation in Alzheimer , s_disease -LRB- AD -RRB- rodent models : Is fractalkine a systemic biomarker for AD ?
12110009	0	CX3CR1	40,46	fractalkine_receptor	18,38	CX3CR1	fractalkine receptor	1524	1524	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the fractalkine_receptor -LRB- CX3CR1 -RRB- in human kidney_diseases .
15128827	0	CXC-chemokine_ligand_16	18,41	IFN-gamma	56,65	CXC-chemokine ligand 16	IFN-gamma	66102(Tax:10090)	15978(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The transmembrane CXC-chemokine_ligand_16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10 .
26497045	0	CXC-chemokine_receptor_2	24,48	CXCR2	50,55	CXC-chemokine receptor 2	CXCR2	3579	3579	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The prognostic value of CXC-chemokine_receptor_2 -LRB- CXCR2 -RRB- in gastric_cancer patients .
24593195	0	CXC-chemokine_receptor_CXCR2_and_suppressor_of_cytokine_signaling-3	12,79	SOCS-3	81,87	CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3	SOCS-3	9021	9021	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of CXC-chemokine_receptor_CXCR2_and_suppressor_of_cytokine_signaling-3 -LRB- SOCS-3 -RRB- in renal_cell_carcinoma .
19233959	0	CXCL-1	31,37	IL-1	97,101	CXCL-1	IL-1	2919	3552	Gene	Gene	produce|xcomp|START_ENTITY produce|nmod|response response|nmod|END_ENTITY	Prostate stromal cells produce CXCL-1 , CXCL-2 , CXCL-3 and IL-8 in response to epithelia-secreted IL-1 .
17652371	0	CXCL-10	75,82	Heme_oxygenase-1	0,16	CXCL-10	Heme oxygenase-1	3627	3162	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Heme_oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells .
15963988	0	CXCL-10	124,131	IP-10	118,123	CXCL-10	IP-10	3627	3627	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	TNF-alpha enhances phenotypic and functional maturation of human epidermal Langerhans cells and induces IL-12 p40 and IP-10 / CXCL-10 production .
17331556	0	CXCL-12	60,67	CXCR4	41,46	CXCL-12	CXCR4	6387	7852	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The role of N-glycosylation sites on the CXCR4 receptor for CXCL-12 binding and signaling and X4_HIV-1_viral_infectivity .
16387844	0	CXCL-8	48,54	interleukin-8	33,46	CXCL-8	interleukin-8	3576	3576	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of human neutrophil interleukin-8 -LRB- CXCL-8 -RRB- to organelle -LRB- s -RRB- distinct from the classical granules and secretory vesicles .
21134476	0	CXCL1	42,47	AP-2	25,29	CXCL1	AP-2	2919	7020	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The transcription factor AP-2 regulates CXCL1 during cartilage development and in osteoarthritis .
11371564	0	CXCL1	46,51	CDP	12,15	CXCL1	CDP	2919	1523	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression role|nmod|regulation role|nmod|END_ENTITY	The role of CDP in the negative regulation of CXCL1 gene expression .
25741424	0	CXCL1	36,41	CXCL12	75,81	CXCL1	CXCL12	2919	6387	Gene	Gene	Pro-inflammatory|appos|START_ENTITY Pro-inflammatory|appos|END_ENTITY	Seminal Levels of Pro-inflammatory -LRB- CXCL1 , CXCL9 , CXCL10 -RRB- and Homeostatic -LRB- CXCL12 -RRB- Chemokines in Men With Asymptomatic Chlamydia_trachomatis Infection .
26401931	0	CXCL1	0,5	Caspase-3	15,24	CXCL1	Caspase-3	14825(Tax:10090)	12367(Tax:10090)	Gene	Gene	Cleavage|compound|START_ENTITY Cleavage|compound|END_ENTITY	CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice : Implications in Alzheimer 's _ Disease .
23772036	0	CXCL1	48,53	HuR	0,3	CXCL1	HuR	2919	1994	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization .
24186876	0	CXCL1	65,70	IL-17	46,51	CXCL1	IL-17	14825(Tax:10090)	16171(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	NADPH oxidase mediates synergistic effects of IL-17 and TNF-a on CXCL1 expression by epithelial cells after lung_ischemia-reperfusion .
24273934	0	CXCL1	21,26	IL-1_alpha	0,10	CXCL1	IL-1 alpha	2919	3552	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IL-1_alpha regulates CXCL1 , CXCL10 and ICAM1 in network form in oral keratinocytes .
22269426	0	CXCL1	0,5	IL-6	26,30	CXCL1	IL-6	14825(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis .
22791336	0	CXCL1	42,47	IL-6	12,16	CXCL1	IL-6	14825(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|compound|START_ENTITY lung_injury|nmod|production mediates|dobj|lung_injury mediates|nsubj|END_ENTITY	Circulating IL-6 mediates lung_injury via CXCL1 production after acute_kidney_injury in mice .
20596077	0	CXCL1	33,38	MITF	57,61	CXCL1	MITF	2919	4286	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth .
26252654	0	CXCL1	27,32	Smad2/3	100,107	CXCL1	Smad2/3	2919	4087;4088	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26252654	0	CXCL1	27,32	Smad2/3	100,107	CXCL1	Smad2/3	2919	4087;4088	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26252654	0	CXCL1	27,32	TGF-b	0,5	CXCL1	TGF-b	2919	7040	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26252654	0	CXCL1	27,32	TGF-b	0,5	CXCL1	TGF-b	2919	7040	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
18250465	0	CXCL1	26,31	Tristetraprolin	0,15	CXCL1	Tristetraprolin	14825(Tax:10090)	22695(Tax:10090)	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Tristetraprolin regulates CXCL1 -LRB- KC -RRB- mRNA stability .
18855195	0	CXCL10	22,28	CCL2	40,44	CXCL10	CCL2	3627	6347	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	High values of alpha -LRB- CXCL10 -RRB- and beta -LRB- CCL2 -RRB- circulating chemokines in patients with psoriatic_arthritis , in presence or absence of autoimmune_thyroiditis .
11523046	0	CXCL10	54,60	CXCR3	27,32	CXCL10	CXCR3	3627	2833	Gene	Gene	chemokines|dobj|START_ENTITY chemokines|nsubj|expression expression|nmod|targeting targeting|compound|END_ENTITY	Differential expression of CXCR3 targeting chemokines CXCL10 , CXCL9 , and CXCL11 in different types of skin_inflammation .
12571234	0	CXCL10	56,62	CXCR3	0,5	CXCL10	CXCR3	15945(Tax:10090)	12766(Tax:10090)	Gene	Gene	IP-10|appos|START_ENTITY sites|nmod|IP-10 END_ENTITY|dep|sites	CXCR3 and heparin binding sites of the chemokine IP-10 -LRB- CXCL10 -RRB- .
12884299	0	CXCL10	77,83	CXCR3	48,53	CXCL10	CXCR3	3627	2833	Gene	Gene	CXCL9|nummod|START_ENTITY regulated|dobj|CXCL9 regulated|nmod|END_ENTITY	CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9 , CXCL10 and CXCL11 .
15081542	0	CXCL10	63,69	CXCR3	41,46	CXCL10	CXCR3	3627	2833	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of the chemokine_receptor CXCR3 and its ligand , CXCL10 , in human breast_adenocarcinoma cell lines .
15194051	0	CXCL10	60,66	CXCR3	107,112	CXCL10	CXCR3	3627	2833	Gene	Gene	activity|nmod|START_ENTITY depends|nsubj|activity depends|nmod|END_ENTITY	The angiostatic activity of interferon-inducible protein-10 / CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan .
15885315	0	CXCL10	148,154	CXCR3	24,29	CXCL10	CXCR3	3627	2833	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Increased expression of CXCR3 and CCR5 on memory CD4 + T-cells migrating into the cerebrospinal fluid of patients with neuroborreliosis : the role of CXCL10 and CXCL11 .
16547260	0	CXCL10	0,6	CXCR3	29,34	CXCL10	CXCR3	15945(Tax:10090)	12766(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	CXCL10 is the key ligand for CXCR3 on CD8 + effector T cells involved in immune surveillance of the lymphocytic_choriomeningitis_virus-infected central nervous system .
16934957	0	CXCL10	18,24	CXCR3	79,84	CXCL10	CXCR3	3627	2833	Gene	Gene	Overexpression|nmod|START_ENTITY activates|nsubj|Overexpression activates|ccomp|expression expression|nsubj|receptor receptor|appos|END_ENTITY	Overexpression of CXCL10 in human prostate LNCaP cells activates its receptor -LRB- CXCR3 -RRB- expression and inhibits cell proliferation .
18533024	0	CXCL10	0,6	CXCR3	73,78	CXCL10	CXCR3	15945(Tax:10090)	12766(Tax:10090)	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|assist assist|nmod|recruitment recruitment|nmod|+ +|compound|END_ENTITY	CXCL10 + T cells and NK cells assist in the recruitment and activation of CXCR3 + and CXCL11 + leukocytes during Mycobacteria-enhanced colitis .
20856926	0	CXCL10	0,6	CXCR3	67,72	CXCL10	CXCR3	15945(Tax:10090)	12766(Tax:10090)	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|proliferation proliferation|nmod|END_ENTITY	CXCL10 can inhibit endothelial cell proliferation independently of CXCR3 .
21895630	0	CXCL10	85,91	CXCR3	129,134	CXCL10	CXCR3	3627	2833	Gene	Gene	ligands|nsubj|START_ENTITY ligands|nmod|END_ENTITY	Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3 .
22287719	0	CXCL10	103,109	CXCR3	129,134	CXCL10	CXCR3	3627	2833	Gene	Gene	attract|nsubj|START_ENTITY attract|dobj|+ +|compound|END_ENTITY	Adjuvant immunotherapy of experimental_autoimmune_encephalomyelitis : immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3 + CXCR6 + and myelin-specific T cells to the draining lymph nodes rather than the central nervous system .
26604174	0	CXCL10	47,53	CXCR3	54,59	CXCL10	CXCR3	3627	2833	Gene	Gene	Back|parataxis|START_ENTITY Back|parataxis|Diabetes Diabetes|dep|Axis Axis|compound|END_ENTITY	Back From the Brink : The Uses of Targeting the CXCL10 : CXCR3 Axis in Type 1 Diabetes .
18046562	0	CXCL10	46,52	IL-1beta	72,80	CXCL10	IL-1beta	3627	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines .
12107104	0	CXCL10	20,26	IP-10	14,19	CXCL10	IP-10	3627	3627	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of IP-10 / CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10 / CXCL10 in the serum of patients with recent-onset Graves ' _ disease .
12107104	0	CXCL10	86,92	IP-10	14,19	CXCL10	IP-10	3627	3627	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of IP-10 / CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10 / CXCL10 in the serum of patients with recent-onset Graves ' _ disease .
16382019	0	CXCL10	68,74	IP-10	62,67	CXCL10	IP-10	245920(Tax:10116)	245920(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Compartment-specific expression and function of the chemokine IP-10 / CXCL10 in a model of renal_endothelial_microvascular_injury .
16825661	0	CXCL10	14,20	IP-10	8,13	CXCL10	IP-10	15945(Tax:10090)	15945(Tax:10090)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of IP-10 / CXCL10 in the progression of pancreatitis-like_injury in mice after murine retroviral_infection .
21303517	0	CXCL10	44,50	IP-10	38,43	CXCL10	IP-10	3627	3627	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Dysregulated expression of MIG/CXCL9 , IP-10 / CXCL10 and CXCL16 and their receptors in systemic_sclerosis .
23684765	0	CXCL10	23,29	MDA5	0,4	CXCL10	MDA5	3627	64135	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MDA5 and ISG56 mediate CXCL10 expression induced by toll-like_receptor_4 activation in U373MG human astrocytoma cells .
22892369	0	CXCL10	83,89	Melanoma_differentiation-associated_gene_5	0,42	CXCL10	Melanoma differentiation-associated gene 5	3627	64135	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Melanoma_differentiation-associated_gene_5 regulates the expression of a chemokine CXCL10 in human mesangial cells : implications for chronic inflammatory_renal_diseases .
20680966	0	CXCL10	37,43	Oncostatin_M	0,12	CXCL10	Oncostatin M	3627	5008	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Oncostatin_M synergistically induces CXCL10 and ICAM-1 expression in IL-1beta-stimulated-human gingival fibroblasts .
24701034	0	CXCL10	32,38	RIG-I	64,69	CXCL10	RIG-I	3627	23586	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Hantaan_virus_infection induces CXCL10 expression through TLR3 , RIG-I , and MDA-5 pathways correlated with the disease severity .
16337473	0	CXCL10	35,41	TH1	55,58	CXCL10	TH1	3627	51497	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production .
14597565	0	CXCL10	47,53	TNF-alpha	14,23	CXCL10	TNF-alpha	3627	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of TNF-alpha - and IFN-gamma-induced CXCL10 expression : participation of the airway smooth muscle in the pulmonary inflammatory response in chronic_obstructive_pulmonary_disease .
22633083	0	CXCL10	87,93	Th1	73,76	CXCL10	Th1	3627	51497	Gene	Gene	chemokine|dobj|START_ENTITY chemokine|nsubj|modulation modulation|nmod|cytokines cytokines|nmod|END_ENTITY	Variable modulation by cytokines and thiazolidinediones of the prototype Th1 chemokine CXCL10 in anaplastic_thyroid_cancer .
23312578	0	CXCL10	0,6	Th1	44,47	CXCL10	Th1	15945(Tax:10090)	57314(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|infiltration infiltration|amod|END_ENTITY	CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase .
26046061	0	CXCL10	30,36	Th1	16,19	CXCL10	Th1	3627	51497	Gene	Gene	chemokine|dobj|START_ENTITY chemokine|nsubj|role role|nmod|END_ENTITY	The role of the Th1 chemokine CXCL10 in vitiligo .
24574215	0	CXCL10	52,58	Thymidine_phosphorylase	0,23	CXCL10	Thymidine phosphorylase	3627	1890	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Thymidine_phosphorylase regulates the expression of CXCL10 in rheumatoid_arthritis fibroblast-like synoviocytes .
24753255	0	CXCL10	43,49	Tumor_necrosis_factor	0,21	CXCL10	Tumor necrosis factor	3627	7124	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	Tumor_necrosis_factor -LRB- TNF -RRB- - a induction of CXCL10 in endothelial cells requires protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- - mediated nuclear factor -LRB- NF -RRB- - kB p65 methylation .
17244787	0	CXCL10	107,113	alpha-chemokine	91,106	CXCL10	alpha-chemokine	3627	3576	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves ' _ disease or toxic_nodular_goiter .
26873848	0	CXCL10	119,125	miR-21	23,29	CXCL10	miR-21	3627	406991	Gene	Gene	Role|nmod|START_ENTITY Expression|dep|Role Expression|amod|END_ENTITY	Estrogen Downregulates miR-21 Expression and Induces Inflammatory Infiltration of Macrophages in Polymyositis : Role of CXCL10 .
22989616	0	CXCL11	62,68	trio	19,23	CXCL11	trio	6373	7204	Gene	Gene	crosstalk|nmod|START_ENTITY END_ENTITY|dep|crosstalk	Chemokine_receptor trio : CXCR3 , CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12 .
16114056	0	CXCL12	131,137	Akt-1	33,38	CXCL12	Akt-1	6387	207	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate_cancer cells : the role of bone microenvironment-associated CXCL12 .
25741424	0	CXCL12	75,81	CXCL1	36,41	CXCL12	CXCL1	6387	2919	Gene	Gene	Pro-inflammatory|appos|START_ENTITY Pro-inflammatory|appos|END_ENTITY	Seminal Levels of Pro-inflammatory -LRB- CXCL1 , CXCL9 , CXCL10 -RRB- and Homeostatic -LRB- CXCL12 -RRB- Chemokines in Men With Asymptomatic Chlamydia_trachomatis Infection .
21357602	0	CXCL12	14,20	CXCL12	64,70	CXCL12	CXCL12	6387	6387	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|effects effects|nmod|END_ENTITY	Expression of CXCL12 and CXCR4 in human endometrium ; effects of CXCL12 on MMP production by human endometrial cells .
21357602	0	CXCL12	64,70	CXCL12	14,20	CXCL12	CXCL12	6387	6387	Gene	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of CXCL12 and CXCR4 in human endometrium ; effects of CXCL12 on MMP production by human endometrial cells .
12444109	0	CXCL12	64,70	CXCR3	31,36	CXCL12	CXCR3	6387	2833	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation .
12239139	0	CXCL12	33,39	CXCR4	153,158	CXCL12	CXCR4	6387	7852	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	CCR5-binding chemokines modulate CXCL12 -LRB- SDF-1 -RRB- - induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor .
12714578	0	CXCL12	30,36	CXCR4	114,119	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Stromal cell-derived factor-1 / CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G -LRB- alpha -RRB- i proteins and enhances engraftment of competitive , repopulating stem cells .
14684377	0	CXCL12	6,12	CXCR4	92,97	CXCL12	CXCR4	6387	7852	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|nmod|cells cells|nmod|END_ENTITY	SDF-1 / CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 .
15358596	0	CXCL12	0,6	CXCR4	21,26	CXCL12	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity .
15479278	0	CXCL12	114,120	CXCR4	70,75	CXCL12	CXCR4	6387	7852	Gene	Gene	factor-1alpha|appos|START_ENTITY ligand|dobj|factor-1alpha ligand|nsubj|activation activation|nmod|END_ENTITY	T-helper 2 cytokines attenuate senescent eosinophil activation by the CXCR4 ligand stromal-derived factor-1alpha -LRB- CXCL12 -RRB- .
15536153	0	CXCL12	103,109	CXCR4	78,83	CXCL12	CXCR4	6387	7852	Gene	Gene	desensitization|nmod|START_ENTITY desensitization|compound|END_ENTITY	WHIM_syndromes with different_genetic_anomalies are accounted for by impaired CXCR4 desensitization to CXCL12 .
15618475	0	CXCL12	101,107	CXCR4	109,114	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	SDF-1alpha|appos|START_ENTITY SDF-1alpha|dep|axis axis|nummod|END_ENTITY	Flt3_ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1alpha -LRB- CXCL12 -RRB- / CXCR4 axis .
15647826	0	CXCL12	54,60	CXCR4	62,67	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	SDF-1|appos|START_ENTITY localization|nmod|SDF-1 localization|parataxis|blocks blocks|nsubj|axis axis|compound|END_ENTITY	Skeletal localization and neutralization of the SDF-1 -LRB- CXCL12 -RRB- / CXCR4 axis blocks prostate_cancer metastasis and growth in osseous sites in vivo .
16267013	0	CXCL12	82,88	CXCR4	17,22	CXCL12	CXCR4	6387	7852	Gene	Gene	increases|appos|START_ENTITY cells|nmod|increases expression|nmod|cells expression|nummod|END_ENTITY	Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha -LRB- CXCL12 -RRB- increases endothelial adhesion and transendothelial migration : role of MEK/ERK signaling pathway-dependent NF-kappaB activation .
16397027	0	CXCL12	0,6	CXCR4	24,29	CXCL12	CXCR4	6387	7852	Gene	Gene	attract|nsubj|START_ENTITY attract|dobj|cells cells|nummod|+ +|compound|END_ENTITY	CXCL12 does not attract CXCR4 + human metastatic_neuroblastoma cells : clinical implications .
16702540	0	CXCL12	20,26	CXCR4	131,136	CXCL12	CXCR4	6387	7852	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|pattern pattern|nmod|neurons neurons|acl|induced induced|nmod|END_ENTITY	The chemokine SDF-1 / CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4 .
16725153	0	CXCL12	101,107	CXCR4	17,22	CXCL12	CXCR4	6387	7852	Gene	Gene	chemokine_stromal_cell-derived_factor-1alpha|appos|START_ENTITY sulfotyrosine|nmod|chemokine_stromal_cell-derived_factor-1alpha sulfotyrosine|nsubj|Recognition Recognition|nmod|END_ENTITY	Recognition of a CXCR4 sulfotyrosine by the chemokine_stromal_cell-derived_factor-1alpha -LRB- SDF-1alpha / CXCL12 -RRB- .
16787495	0	CXCL12	136,142	CXCR4	154,159	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro .
16875673	0	CXCL12	31,37	CXCR4	112,117	CXCL12	CXCR4	6387	7852	Gene	Gene	factor|appos|START_ENTITY binds|nsubj|factor binds|xcomp|endothelial endothelial|nmod|receptor receptor|amod|different different|nmod|END_ENTITY	Stromal cell-derived factor 1 -LRB- CXCL12 -RRB- binds to endothelial cells and signals through a receptor different from CXCR4 .
17056593	0	CXCL12	10,16	CXCR4	83,88	CXCL12	CXCR4	6387	7852	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Chemokine CXCL12 induces binding of ferritin_heavy_chain to the chemokine_receptor CXCR4 , alters CXCR4 signaling , and induces phosphorylation and nuclear translocation of ferritin_heavy_chain .
17165132	0	CXCL12	20,26	CXCR4	35,40	CXCL12	CXCR4	6387	7852	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|nummod|END_ENTITY	The pivotal role of CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis in bone metastasis .
17468394	0	CXCL12	100,106	CXCR4	140,145	CXCL12	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	reduces|dobj|START_ENTITY reduces|nmod|decrease decrease|nmod|receptors receptors|nummod|END_ENTITY	Progesterone reduces the migration of mast cells toward the chemokine stromal cell-derived factor-1 / CXCL12 with an accompanying decrease in CXCR4 receptors .
18436740	0	CXCL12	95,101	CXCR4	0,5	CXCL12	CXCR4	6387	7852	Gene	Gene	account|nmod|START_ENTITY account|nsubj|dimerization dimerization|nummod|END_ENTITY	CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM_syndrome .
18753332	0	CXCL12	48,54	CXCR4	25,30	CXCL12	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY expression|dep|gene expression|nmod|END_ENTITY	Functional expression of CXCR4 in somatotrophs : CXCL12 activates GH gene , GH production and secretion , and cellular proliferation .
18799424	0	CXCL12	75,81	CXCR4	20,25	CXCL12	CXCR4	6387	7852	Gene	Gene	sulfotyrosine|nmod|START_ENTITY sulfotyrosine|nsubj|basis basis|nmod|END_ENTITY	Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1 / CXCL12 .
18954561	0	CXCL12	63,69	CXCR4	31,36	CXCL12	CXCR4	6387	7852	Gene	Gene	12|appos|START_ENTITY ligand|dobj|12 ligand|nsubj|Roles Roles|nmod|receptor receptor|appos|END_ENTITY	Roles of chemokine receptor 4 -LRB- CXCR4 -RRB- and chemokine ligand 12 -LRB- CXCL12 -RRB- in metastasis of hepatocellular_carcinoma cells .
19109200	0	CXCL12	18,24	CXCR4	48,53	CXCL12	CXCR4	6387	7852	Gene	Gene	Citrullination|nmod|START_ENTITY reduces|nsubj|Citrullination reduces|xcomp|binding binding|nsubj|END_ENTITY	Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory_and_anti-HIV-1_activity_via_CXCR4 .
19443644	0	CXCL12	4,10	CXCR4	19,24	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	START_ENTITY|dep|axis axis|nummod|END_ENTITY	The CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis is essential for the development of renal vasculature .
19594447	0	CXCL12	15,21	CXCR4	61,66	CXCL12	CXCR4	6387	7852	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7 .
20459090	0	CXCL12	16,22	CXCR4	65,70	CXCL12	CXCR4	6387	7852	Gene	Gene	START_ENTITY|acl:relcl|prevents prevents|dobj|activation activation|nmod|END_ENTITY	Targeting SDF-1 / CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design .
20484021	0	CXCL12	0,6	CXCR4	15,20	CXCL12	CXCR4	6387	7852	Gene	Gene	/|nsubj|START_ENTITY /|dobj|pathway pathway|nummod|END_ENTITY	CXCL12 -LRB- SDF-1 -RRB- / CXCR4 pathway in cancer .
20534452	0	CXCL12	56,62	CXCR4	81,86	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple_sclerosis .
21215244	0	CXCL12	21,27	CXCR4	36,41	CXCL12	CXCR4	6387	7852	Gene	Gene	Dysfunctions|nmod|START_ENTITY Dysfunctions|parataxis|signaling signaling|nsubj|END_ENTITY	-LSB- Dysfunctions of the CXCL12 -LRB- SDF-1 -RRB- / CXCR4 signaling axis in the WHIM_syndrome and the idiopathic CD4 -LRB- + -RRB- T-cell lymphocytopenia -RSB- .
21332278	0	CXCL12	42,48	CXCR4	35,40	CXCL12	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Spatiotemporal Spatiotemporal|appos|END_ENTITY	Spatiotemporal CCR1 , CCL3 -LRB- MIP-1a -RRB- , CXCR4 , CXCL12 -LRB- SDF-1a -RRB- expression patterns in a rat spinal_cord_injury model of posttraumatic neuropathic_pain .
21695171	0	CXCL12	36,42	CXCR4	64,69	CXCL12	CXCR4	6387	7852	Gene	Gene	receptors|nummod|START_ENTITY receptors|appos|END_ENTITY	Differential estrogen-regulation of CXCL12 chemokine receptors , CXCR4 and CXCR7 , contributes to the growth effect of estrogens in breast_cancer cells .
21878648	0	CXCL12	10,16	CXCR4	22,27	CXCL12	CXCR4	6387	7852	Gene	Gene	uses|nsubj|START_ENTITY uses|ccomp|formed formed|nsubj|END_ENTITY	Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt , extracellular_signal-regulated_kinase _ -LRB- ERK -RRB- 1/2 , and mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- proteins to control chemotaxis and survival simultaneously in mature dendritic cells .
22114110	0	CXCL12	30,36	CXCR4	46,51	CXCL12	CXCR4	6387	7852	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Trophoblast-derived chemokine CXCL12 promotes CXCR4 expression and invasion of human first-trimester decidual stromal cells .
22472349	0	CXCL12	10,16	CXCR4	32,37	CXCL12	CXCR4	6387	7852	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic_cancer cells .
23133664	0	CXCL12	104,110	CXCR4	19,24	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	migration|nmod|START_ENTITY migration|nsubj|END_ENTITY	Dasatinib inhibits CXCR4 signaling in chronic_lymphocytic_leukaemia cells and impairs migration towards CXCL12 .
23289420	0	CXCL12	58,64	CXCR4	0,5	CXCL12	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	unit|nmod|START_ENTITY form|dobj|unit form|nsubj|END_ENTITY	CXCR4 and CXCR7 form a functional receptor unit for SDF-1 / CXCL12 in primary rodent microglia .
23333329	0	CXCL12	39,45	CXCR4	68,73	CXCL12	CXCR4	6387	7852	Gene	Gene	function|nmod|START_ENTITY inhibit|dobj|function inhibit|nmod|down-regulation down-regulation|nmod|END_ENTITY	CXCR7 agonists inhibit the function of CXCL12 by down-regulation of CXCR4 .
24292718	0	CXCL12	31,37	CXCR4	61,66	CXCL12	CXCR4	6387	7852	Gene	Gene	system|compound|START_ENTITY peculiarities|nmod|system peculiarities|parataxis|sing sing|nsubj|END_ENTITY	The peculiarities of the SDF-1 / CXCL12 system : in some cells , CXCR4 and CXCR7 sing solos , in others , they sing duets .
24480462	0	CXCL12	83,89	CXCR4	49,54	CXCL12	CXCR4	6387	7852	Gene	Gene	derived|nmod|START_ENTITY derived|nmod|loops loops|compound|END_ENTITY	Neutralising properties of peptides derived from CXCR4 extracellular loops towards CXCL12 binding and HIV-1_infection .
24497931	0	CXCL12	92,98	CXCR4	74,79	CXCL12	CXCR4	6387	7852	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	CXCR7 is highly expressed in acute_lymphoblastic_leukemia and potentiates CXCR4 response to CXCL12 .
24660779	0	CXCL12	50,56	CXCR4	77,82	CXCL12	CXCR4	6387	7852	Gene	Gene	START_ENTITY|acl|binding binding|nmod|END_ENTITY	Elucidating a key component of cancer metastasis : CXCL12 -LRB- SDF-1a -RRB- binding to CXCR4 .
24722947	0	CXCL12	25,31	CXCR4	50,55	CXCL12	CXCR4	6387	7852	Gene	Gene	CXC_chemokine_ligand_12|appos|START_ENTITY END_ENTITY|nsubj|CXC_chemokine_ligand_12	CXC_chemokine_ligand_12 -LRB- CXCL12 -RRB- and its receptor CXCR4 .
24870556	0	CXCL12	98,104	CXCR4	61,66	CXCL12	CXCR4	6387	7852	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Breast_cancer metastasis : demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12 .
24904289	0	CXCL12	0,6	CXCR4	21,26	CXCL12	CXCR4	6387	7852	Gene	Gene	modulation|nummod|START_ENTITY modulation|nmod|activity activity|compound|END_ENTITY	CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment .
25305322	0	CXCL12	115,121	CXCR4	51,56	CXCL12	CXCR4	6387	7852	Gene	Gene	Triggers|nmod|START_ENTITY Triggers|dobj|Migration Migration|compound|END_ENTITY	Synaptic Release of CCL5 Storage Vesicles Triggers CXCR4 Surface Expression Promoting CTL Migration in Response to CXCL12 .
25833331	0	CXCL12	52,58	CXCR4	74,79	CXCL12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	Independent|compound|START_ENTITY Migration|nmod|Independent Migration|nmod|END_ENTITY	CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4 .
26813575	0	CXCL12	98,104	CXCR4	34,39	CXCL12	CXCR4	6387	7852	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of chemokine receptor CXCR4 in monomeric and dimeric state with its endogenous ligand CXCL12 : Coarse-grained simulations identify differences .
26818832	0	CXCL12	37,43	CXCR4	18,23	CXCL12	CXCR4	6387	7852	Gene	Gene	important|nsubj|START_ENTITY Expression|parataxis|important Expression|nmod|SDF-1 SDF-1|compound|END_ENTITY	Expression of the CXCR4 ligand SDF-1 / CXCL12 is prognostically important for adenocarcinoma and large_cell_carcinoma_of_the_lung .
20161793	0	CXCL12	35,41	CXCR7	0,5	CXCL12	CXCR7	6387	57007	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	CXCR7 functions as a scavenger for CXCL12 and CXCL11 .
20839032	0	CXCL12	0,6	CXCR7	17,22	CXCL12	CXCR7	6387	57007	Gene	Gene	CXCR4|compound|START_ENTITY CXCR4|parataxis|chemokine chemokine|nsubj|END_ENTITY	CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression .
21084856	0	CXCL12	22,28	CXCR7	39,44	CXCL12	CXCR7	6387	57007	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Expression of the new CXCL12 receptor , CXCR7 , in gliomas .
21300915	0	CXCL12	82,88	CXCR7	0,5	CXCL12	CXCR7	6387	57007	Gene	Gene	abundance|compound|START_ENTITY controlling|dobj|abundance influences|advcl|controlling influences|nsubj|END_ENTITY	CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity .
21470690	0	CXCL12	49,55	CXCR7	0,5	CXCL12	CXCR7	6387	57007	Gene	Gene	receptors|nmod|START_ENTITY receptors|nsubj|END_ENTITY	CXCR7 and syndecan-4 are potential receptors for CXCL12 in human cytotrophoblasts .
22088972	0	CXCL12	15,21	CXCR7	32,37	CXCL12	CXCR7	6387	57007	Gene	Gene	receptor|compound|START_ENTITY role|nmod|receptor role|appos|END_ENTITY	A role for the CXCL12 receptor , CXCR7 , in the pathogenesis of human pulmonary_vascular_disease .
22736769	0	CXCL12	32,38	CXCR7	49,54	CXCL12	CXCR7	6387	57007	Gene	Gene	uptake|nmod|START_ENTITY depend|nsubj|uptake depend|nmod|residues residues|nummod|END_ENTITY	Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues .
22987307	0	CXCL12	0,6	CXCR7	64,69	CXCL12	CXCR7	6387	57007	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|endocytotic endocytotic|amod|END_ENTITY	CXCL12 enhances human neural progenitor cell survival through a CXCR7 - and CXCR4-mediated endocytotic signaling pathway .
23153575	0	CXCL12	16,22	CXCR7	0,5	CXCL12	CXCR7	6387	57007	Gene	Gene	biology|compound|START_ENTITY impact|nmod|biology impact|nummod|END_ENTITY	CXCR7 impact on CXCL12 biology and disease .
23333329	0	CXCL12	39,45	CXCR7	0,5	CXCL12	CXCR7	6387	57007	Gene	Gene	function|nmod|START_ENTITY inhibit|dobj|function inhibit|nsubj|agonists agonists|compound|END_ENTITY	CXCR7 agonists inhibit the function of CXCL12 by down-regulation of CXCR4 .
24116850	0	CXCL12	63,69	CXCR7	26,31	CXCL12	CXCR7	20315(Tax:10090)	12778(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY expression|nmod|levels expression|nmod|END_ENTITY	Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels .
24174685	0	CXCL12	85,91	CXCR7	26,31	CXCL12	CXCR7	20315(Tax:10090)	12778(Tax:10090)	Gene	Gene	availability|compound|START_ENTITY regulating|dobj|availability affects|advcl|regulating affects|nsubj|CXC_chemokine_receptor_7 CXC_chemokine_receptor_7|appos|END_ENTITY	CXC_chemokine_receptor_7 -LRB- CXCR7 -RRB- affects the migration of GnRH neurons by regulating CXCL12 availability .
24497931	0	CXCL12	92,98	CXCR7	0,5	CXCL12	CXCR7	6387	57007	Gene	Gene	response|nmod|START_ENTITY expressed|nmod|response expressed|nsubjpass|END_ENTITY	CXCR7 is highly expressed in acute_lymphoblastic_leukemia and potentiates CXCR4 response to CXCL12 .
25084358	0	CXCL12	54,60	CXCR7	19,24	CXCL12	CXCR7	6387	57007	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells .
25833331	0	CXCL12	52,58	CXCR7	0,5	CXCL12	CXCR7	20315(Tax:10090)	12778(Tax:10090)	Gene	Gene	Independent|compound|START_ENTITY Migration|nmod|Independent Migration|compound|END_ENTITY	CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4 .
26721509	0	CXCL12	21,27	Connexin_43	0,11	CXCL12	Connexin 43	24772(Tax:10116)	24392(Tax:10116)	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Connexin_43 Mediates CXCL12 Production from Spinal Dorsal Horn to Maintain Bone_Cancer_Pain in Rats .
22978573	0	CXCL12	7,13	Cxcr4	77,82	CXCL12	Cxcr4	6387	7852	Gene	Gene	Sdf-1|appos|START_ENTITY improves|nsubj|Sdf-1 improves|dep|expressing expressing|nsubj|regeneration regeneration|nmod|mobilisation mobilisation|nmod|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- improves skeletal muscle regeneration via the mobilisation of Cxcr4 and CD34 expressing cells .
19302476	0	CXCL12	0,6	FOXO3a	74,80	CXCL12	FOXO3a	6387	2309	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	CXCL12 increases human neural progenitor cell proliferation through Akt-1 / FOXO3a signaling pathway .
24870556	0	CXCL12	98,104	FOXP3	45,50	CXCL12	FOXP3	6387	50943	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Breast_cancer metastasis : demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12 .
22529914	0	CXCL12	0,6	HER1	59,63	CXCL12	HER1	6387	1956	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|compound|END_ENTITY	CXCL12 and -LSB- N33A -RSB- CXCL12 in 5637 and HeLa cells : regulating HER1 phosphorylation via calmodulin/calcineurin .
19535637	0	CXCL12	60,66	IL-1R	0,5	CXCL12	IL-1R	6387	3554	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis .
21332278	0	CXCL12	42,48	MIP-1a	26,32	CXCL12	MIP-1a	24772(Tax:10116)	25542(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Spatiotemporal Spatiotemporal|appos|END_ENTITY	Spatiotemporal CCR1 , CCL3 -LRB- MIP-1a -RRB- , CXCR4 , CXCL12 -LRB- SDF-1a -RRB- expression patterns in a rat spinal_cord_injury model of posttraumatic neuropathic_pain .
19660434	0	CXCL12	24,30	PI3Kgamma	0,9	CXCL12	PI3Kgamma	6387	5294	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	PI3Kgamma activation by CXCL12 regulates tumor cell adhesion and invasion .
11870628	0	CXCL12	40,46	SDF-1	48,53	CXCL12	SDF-1	6387	6387	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Activation of pertussis toxin-sensitive CXCL12 -LRB- SDF-1 -RRB- receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells .
14684377	0	CXCL12	6,12	SDF-1	0,5	CXCL12	SDF-1	6387	6387	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	SDF-1 / CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 .
15882617	0	CXCL12	125,131	SDF-1	119,124	CXCL12	SDF-1	6387	6387	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Stromal fibroblasts present in invasive human breast_carcinomas promote tumor growth and angiogenesis through elevated SDF-1 / CXCL12 secretion .
16212649	0	CXCL12	20,26	SDF-1	14,19	CXCL12	SDF-1	6387	6387	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|parataxis|contributes	The chemokine SDF-1 / CXCL12 contributes to T lymphocyte recruitment in human pre-ovulatory follicles and coordinates with lymphocytes to increase granulosa cell survival and embryo quality .
16259636	0	CXCL12	55,61	SDF-1	48,53	CXCL12	SDF-1	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The neuroblast and angioblast chemotaxic factor SDF-1 -LRB- CXCL12 -RRB- expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic_injury .
16702540	0	CXCL12	20,26	SDF-1	14,19	CXCL12	SDF-1	6387	6387	Gene	Gene	modulates|nsubj|START_ENTITY END_ENTITY|parataxis|modulates	The chemokine SDF-1 / CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4 .
19281787	0	CXCL12	20,26	SDF-1	14,19	CXCL12	SDF-1	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	The chemokine SDF-1 / CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles .
19937807	0	CXCL12	20,26	SDF-1	14,19	CXCL12	SDF-1	24772(Tax:10116)	24772(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|parataxis|contributes	The chemokine SDF-1 / CXCL12 contributes to the ` homing ' of umbilical cord blood cells to a hypoxic-ischemic_lesion in the rat brain .
20459090	0	CXCL12	16,22	SDF-1	10,15	CXCL12	SDF-1	6387	6387	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting SDF-1 / CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design .
20869048	0	CXCL12	54,60	SDF-1	48,53	CXCL12	SDF-1	6387	6387	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Estrogen induces stromal cell-derived factor 1 -LRB- SDF-1 / CXCL12 -RRB- production in human endometrial stromal cells : a possible role of endometrial epithelial cell growth .
22951280	0	CXCL12	30,36	SDF-1	24,29	CXCL12	SDF-1	6387	6387	Gene	Gene	involvement|dep|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of SDF-1 / CXCL12 in the pathogenesis of Degos_disease .
24292718	0	CXCL12	31,37	SDF-1	25,30	CXCL12	SDF-1	6387	6387	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	The peculiarities of the SDF-1 / CXCL12 system : in some cells , CXCR4 and CXCR7 sing solos , in others , they sing duets .
25466898	0	CXCL12	6,12	SDF-1	0,5	CXCL12	SDF-1	6387	6387	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|appos|induces	SDF-1 / CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gai/mTORC1 axis .
26093947	0	CXCL12	15,21	SDF-1	8,13	CXCL12	SDF-1	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of SDF-1 -LRB- CXCL12 -RRB- in regulating hematopoietic stem and progenitor cells traffic into the liver during extramedullary hematopoiesis induced by G-CSF , AMD3100 and PHZ .
16284526	0	CXCL12	50,56	SDF1	58,62	CXCL12	SDF1	6387	6387	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Risk for HIV-1_infection associated with a common CXCL12 -LRB- SDF1 -RRB- polymorphism and CXCR4 variation in an African population .
21179442	0	CXCL12	26,32	SDF1	34,38	CXCL12	SDF1	6387	6387	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MiR-886-3p down regulates CXCL12 -LRB- SDF1 -RRB- expression in human marrow stromal cells .
22462026	0	CXCL12	38,44	Stromal-Cell-Derived_Factor-1	0,29	CXCL12	Stromal-Cell-Derived Factor-1	6387	6387	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Stromal-Cell-Derived_Factor-1 -LRB- SDF-1 -RRB- / CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg_Ischaemia .
25121739	0	CXCL12	0,6	connective_tissue_growth_factor	15,46	CXCL12	connective tissue growth factor	6387	1490	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	CXCL12 induces connective_tissue_growth_factor expression in human lung fibroblasts through the Rac1/ERK , JNK , and AP-1 pathways .
23262036	0	CXCL12	10,16	connexin_43	61,72	CXCL12	connexin 43	6387	2697	Gene	Gene	activates|nsubj|START_ENTITY activates|xcomp|phosphorylate phosphorylate|dobj|END_ENTITY	Exogenous CXCL12 activates protein kinase C to phosphorylate connexin_43 for gap junctional intercellular communication among confluent breast_cancer cells .
16905744	0	CXCL12	0,6	cortactin	43,52	CXCL12	cortactin	6387	2017	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	CXCL12 induces tyrosine phosphorylation of cortactin , which plays a role in CXC_chemokine_receptor_4-mediated extracellular signal-regulated kinase activation and chemotaxis .
26103953	0	CXCL12	84,90	miR-448	0,7	CXCL12	miR-448	6387	554212	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-448 negatively regulates ovarian_cancer cell growth and metastasis by targeting CXCL12 .
26103953	0	CXCL12	84,90	miR-448	0,7	CXCL12	miR-448	6387	554212	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-448 negatively regulates ovarian_cancer cell growth and metastasis by targeting CXCL12 .
23042661	0	CXCL12	7,13	stroke	46,52	CXCL12	CXCL12	6387	6387	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Plasma CXCL12 levels as a predictor of future stroke .
21576203	0	CXCL13	66,72	B-cell-attracting_chemokine-1	29,58	CXCL13	B-cell-attracting chemokine-1	10563	10563	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Elevated production of serum B-cell-attracting_chemokine-1 -LRB- BCA-1 / CXCL13 -RRB- is correlated with childhood-onset lupus_disease activity , severity , and renal involvement .
12393412	0	CXCL13	45,51	B-cell-attracting_chemokine_1	14,43	CXCL13	B-cell-attracting chemokine 1	10563	10563	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of B-cell-attracting_chemokine_1 -LRB- CXCL13 -RRB- by malignant lymphocytes and vascular endothelium in primary central_nervous_system_lymphoma .
19031272	0	CXCL13	11,17	BCA-1	19,24	CXCL13	BCA-1	10563	10563	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for CXCL13 -LRB- BCA-1 -RRB- in pregnancy and intra-amniotic_infection / inflammation .
21084753	0	CXCL13	77,83	biglycan	17,25	CXCL13	biglycan	55985(Tax:10090)	12111(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus_nephritis .
15651028	0	CXCL14	14,20	BRAK	22,26	CXCL14	BRAK	9547	9547	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Modulation of CXCL14 -LRB- BRAK -RRB- expression in prostate_cancer .
19673887	0	CXCL14	22,28	BRAK	15,19	CXCL14	BRAK	9547	9547	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Restoration of BRAK / CXCL14 gene expression by gefitinib is associated with antitumor efficacy of the drug in head_and_neck_squamous_cell_carcinoma .
21978833	0	CXCL14	28,34	BRAK	36,40	CXCL14	BRAK	57266(Tax:10090)	57266(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Neutralization of chemokine CXCL14 -LRB- BRAK -RRB- expression reduces CCl4 induced liver_injury and steatosis in mice .
25451233	0	CXCL14	0,6	CXCR4	33,38	CXCL14	CXCR4	9547	7852	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|END_ENTITY	CXCL14 is no direct modulator of CXCR4 .
26428435	0	CXCL14	0,6	CXCR7	8,13	CXCL14	CXCR7	9547	57007	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	CXCL14 , CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing_sarcoma patients .
21955359	0	CXCL14	19,25	chemokine_BRAK	4,18	CXCL14	chemokine BRAK	57266(Tax:10090)	57266(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	The chemokine_BRAK / CXCL14 regulates synaptic transmission in the adult mouse dentate gyrus stem cell niche .
17242461	0	CXCL15	14,20	Lungkine	22,30	CXCL15	Lungkine	20309(Tax:10090)	20309(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CXCL15 -LRB- Lungkine -RRB- in murine gastrointestinal , urogenital , and endocrine organs .
26272362	0	CXCL16	31,37	C-X-C_Chemokine_Receptor	55,79	CXCL16	C-X-C Chemokine Receptor	58191	10663	Gene	Gene	Significance|nmod|START_ENTITY END_ENTITY|nsubj|Significance	The Prognostic Significance of CXCL16 and Its Receptor C-X-C_Chemokine_Receptor 6 in Prostate_Cancer .
25391425	0	CXCL16	55,61	MiR-451	0,7	CXCL16	MiR-451	58191	574411	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-451 inhibits cell growth and invasion by targeting CXCL16 and is associated with prognosis of osteosarcoma patients .
25683115	0	CXCL16	149,155	PI3K	112,116	CXCL16	PI3K	66102(Tax:10090)	18708(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Loss of Somatostatin-Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic_Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16 .
26621504	0	CXCL16	0,6	RANKL	19,24	CXCL16	RANKL	58191	8600	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	CXCL16 upregulates RANKL expression in rheumatoid_arthritis synovial fibroblasts through the JAK2/STAT3 and p38/MAPK signaling pathway .
22278019	0	CXCL16	71,77	TWEAK	0,5	CXCL16	TWEAK	58191	8742	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	TWEAK -LRB- tumor_necrosis_factor-like_weak_inducer_of_apoptosis -RRB- activates CXCL16 expression during renal tubulointerstitial_inflammation .
23891907	0	CXCL16	42,48	Transforming_growth_factor_beta_1	0,33	CXCL16	Transforming growth factor beta 1	58191	7040	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 induces CXCL16 and leukemia_inhibitory_factor expression in osteoclasts to modulate migration of osteoblast progenitors .
17130903	0	CXCL2	23,28	MIP-2	16,21	CXCL2	MIP-2	20310(Tax:10090)	20310(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Upregulation of MIP-2 -LRB- CXCL2 -RRB- expression by 15-deoxy-Delta -LRB- 12,14 -RRB- - prostaglandin_J -LRB- 2 -RRB- in mouse peritoneal macrophages .
19910578	0	CXCL4	0,5	CD163	61,66	CXCL4	CD163	5196	9332	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages .
15265941	0	CXCL4	18,23	Platelet_factor_4	0,17	CXCL4	Platelet factor 4	5196	5196	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Platelet_factor_4 / CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients .
12680872	0	CXCL5	61,66	ENA-78	54,60	CXCL5	ENA-78	6374	6374	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of the neutrophil-activating CXC chemokine ENA-78 / CXCL5 by human eosinophils .
25692402	0	CXCL5	29,34	Oncostatin-M	76,88	CXCL5	Oncostatin-M	20311(Tax:10090)	18413(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia .
18809212	0	CXCL6	65,70	GCP-2	59,64	CXCL6	GCP-2	6372	6372	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Constitutive expression of the antibacterial CXC chemokine GCP-2 / CXCL6 by epithelial cells of the male reproductive tract .
16721367	0	CXCL6	65,70	granulocyte_chemotactic_protein-2	31,64	CXCL6	granulocyte chemotactic protein-2	6372	6372	Gene	Gene	Production|dep|START_ENTITY Production|nmod|END_ENTITY	Production and upregulation of granulocyte_chemotactic_protein-2 / CXCL6 by IL-1beta and hypoxia in small_cell_lung_cancer .
26297794	0	CXCL8	41,46	A1a	14,17	CXCL8	A1a	3576	5265	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Serum amyloid A1a induces paracrine IL-8 / CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils .
26908203	0	CXCL8	18,23	CCL2	35,39	CXCL8	CCL2	3576	6347	Gene	Gene	IL-8|appos|START_ENTITY IL-8|appos|END_ENTITY	Induction of IL-8 -LRB- CXCL8 -RRB- and MCP-1 -LRB- CCL2 -RRB- with oxidative stress and its inhibition with N-acetyl_cysteine -LRB- NAC -RRB- in cell culture model using HK-2 cell .
12051749	0	CXCL8	0,5	CXCR1	68,73	CXCL8	CXCR1	3576	3577	Gene	Gene	K11R/G31P|nsubj|START_ENTITY K11R/G31P|ccomp|ligand ligand|xcomp|binding binding|nmod|END_ENTITY	CXCL8 -LRB- -LRB- 3-73 -RRB- -RRB- K11R/G31P antagonizes ligand binding to the neutrophil CXCR1 and CXCR2 receptors and cellular responses to CXCL8/IL -8 .
15579377	0	CXCL8	0,5	CXCR1	60,65	CXCL8	CXCR1	3576	3577	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|pathway pathway|compound|END_ENTITY	CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway .
15974585	0	CXCL8	81,86	CXCR1	42,47	CXCL8	CXCR1	3576	3577	Gene	Gene	inhibitors|compound|START_ENTITY ligands|nmod|inhibitors ligands|nsubj|CXC_chemokine_receptor_1 CXC_chemokine_receptor_1|appos|END_ENTITY	2-Arylpropionic CXC_chemokine_receptor_1 -LRB- CXCR1 -RRB- ligands as novel noncompetitive CXCL8 inhibitors .
17197447	0	CXCL8	72,77	CXCR1	7,12	CXCR2	CXCR1	3579	227288(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Murine CXCR1 is a functional receptor for GCP-2 / CXCL6 and interleukin-8 / CXCL8 .
17876799	0	CXCL8	53,58	CXCR1	25,30	CXCL8	CXCR1	3576	3577	Gene	Gene	receptor|nmod|START_ENTITY studies|appos|receptor studies|nmod|END_ENTITY	Computational studies of CXCR1 , the receptor of IL-8 / CXCL8 , using molecular dynamics and electrostatics .
19667085	0	CXCL8	61,66	CXCR1	42,47	CXCL8	CXCR1	3576	3577	Gene	Gene	monomer|compound|START_ENTITY Differential|nmod|monomer Differential|dobj|activation activation|nmod|END_ENTITY	Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer .
26689258	0	CXCL8	22,27	CXCR1	101,106	CXCL8	CXCR1	3576	3577	Gene	Gene	derived|nmod|START_ENTITY Peptides|acl|derived inhibit|nsubj|Peptides inhibit|dobj|interactions interactions|nmod|END_ENTITY	Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1 .
26689258	0	CXCL8	64,69	CXCR1	101,106	CXCL8	CXCR1	3576	3577	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1 .
12533683	0	CXCL8	170,175	GCP-2	18,23	CXCL8	GCP-2	3576	6372	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	The CXC chemokine GCP-2 / CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma : comparison with interleukin-8 / CXCL8 .
17392576	0	CXCL8	188,193	IL-10	202,207	CXCL8	IL-10	3576	3586	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|IL-13 IL-13|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17392576	0	CXCL8	188,193	IL-13	209,214	CXCL8	IL-13	3576	3596	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17392576	0	CXCL8	188,193	IL-2	164,168	CXCL8	IL-2	3576	3558	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17392576	0	CXCL8	188,193	IL-4	170,174	CXCL8	IL-4	3576	3565	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17392576	0	CXCL8	188,193	IL-5	176,180	CXCL8	IL-5	3576	3567	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17392576	0	CXCL8	188,193	IL-6	182,186	CXCL8	IL-6	3576	3569	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17586662	0	CXCL8	61,66	IL-8	56,60	CXCL8	IL-8	3576	3576	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Molecular mechanisms of thrombin-induced interleukin-8 -LRB- IL-8 / CXCL8 -RRB- expression in THP-1-derived and primary human macrophages .
22394598	0	CXCL8	50,55	IL-8	45,49	CXCL8	IL-8	3576	3576	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	ALK+ALCL s induce cutaneous , HMGB-1-dependent IL-8 / CXCL8 production by keratinocytes through NF-kB activation .
15545974	0	CXCL8	14,19	Interleukin-8	0,13	CXCL8	Interleukin-8	3576	3576	Gene	Gene	factor|nsubj|START_ENTITY END_ENTITY|parataxis|factor	Interleukin-8 / CXCL8 is a growth factor for human lung_cancer cells .
24277696	0	CXCL8	70,75	MEKK1	91,96	CXCL8	MEKK1	3576	4214	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Thrombin-induced CCAAT/enhancer-binding protein b activation and IL-8 / CXCL8 expression via MEKK1 , ERK , and p90 ribosomal S6 kinase 1 in lung epithelial cells .
15516694	0	CXCL8	126,131	Membrane_type_1-matrix_metalloproteinase	0,40	CXCL8	Membrane type 1-matrix metalloproteinase	3576	4323	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Membrane_type_1-matrix_metalloproteinase is regulated by chemokines monocyte-chemoattractant_protein-1 / ccl2 and interleukin-8 / CXCL8 in endothelial cells during angiogenesis .
23407636	0	CXCL8	52,57	THP-1	118,123	CXCL8	THP-1	3576	2736	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Opposite effect of angiotensin receptor blockade on CXCL8 production and CXCR1/2 expression of angiotensin_II-treated THP-1 monocytes .
24501198	0	CXCL8	78,83	TSG-6	0,5	CXCL8	TSG-6	3576	7130	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8 .
12618418	0	CXCL8	42,47	interleukin-8	28,41	CXCL8	interleukin-8	3576	3576	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Pathophysiological roles of interleukin-8 / CXCL8 in pulmonary_diseases .
15801837	0	CXCL8	58,63	interleukin-8	43,56	CXCL8	interleukin-8	3576	3576	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Predicting human serum albumin affinity of interleukin-8 -LRB- CXCL8 -RRB- inhibitors by 3D-QSPR approach .
16556047	0	CXCL8	35,40	interleukin-8	21,34	CXCL8	interleukin-8	3576	3576	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Mitogenic effects of interleukin-8 / CXCL8 on cancer cells .
21349590	0	CXCL9	54,59	CCL2	36,40	CXCL9	CCL2	4283	6347	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
21349590	0	CXCL9	54,59	CCL3	42,46	CXCL9	CCL3	4283	6348	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
21349590	0	CXCL9	54,59	CCL5	48,52	CXCL9	CCL5	4283	6352	Gene	Gene	modulates|nummod|START_ENTITY modulates|nummod|END_ENTITY	Equine_herpesvirus_type-1 modulates CCL2 , CCL3 , CCL5 , CXCL9 , and CXCL10 chemokine expression .
12932287	0	CXCL9	61,66	CXCR3	5,10	CXCL9	CXCR3	4283	2833	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubj|expression expression|compound|END_ENTITY	High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid_arthritis .
17274000	0	CXCL9	47,52	IL-18	0,5	CXCL9	IL-18	4283	3606	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IL-18 enhances IFN-gamma-induced production of CXCL9 , CXCL10 , and CXCL11 in human keratinocytes .
18980207	0	CXCL9	23,28	MIG	30,33	CXCL9	MIG	4283	4283	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abundant expression of CXCL9 -LRB- MIG -RRB- by stromal cells that include dendritic_cells and accumulation of CXCR3 + T cells in lymphocyte-rich gastric_carcinoma .
12792744	0	CXCL9	23,28	Mig	18,21	CXCL9	Mig	17329(Tax:10090)	17329(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the Mig -LRB- CXCL9 -RRB- gene in murine lung_carcinoma cells generated angiogenesis-independent antitumor effects .
26892362	0	CXCL9	58,63	Progranulin	0,11	CXCL9	Progranulin	17329(Tax:10090)	14824(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner .
9373270	0	CXCR-1	160,166	interleukin-8	136,149	CXCR-1	interleukin-8	3577	3576	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The CXC-chemokine neutrophil-activating_peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2 .
11563633	0	CXCR-4	20,26	CCR-5	14,19	CXCR-4	CCR-5	7852	1234	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of CCR-5 / CXCR-4 in spinal cord of patients with AIDS .
18827024	0	CXCR-4	181,187	SDF-1	188,193	CXCR-4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	homing|nmod|START_ENTITY associated|nmod|homing administration|acl|associated administration|parataxis|axis axis|nsubj|END_ENTITY	Erythropoietin administration after myocardial_infarction in mice attenuates ischemic_cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4 / SDF-1 axis .
25338599	0	CXCR-4	82,88	SDF-1	76,81	CXCR-4	HMGB1	7852	3146	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Extracellular HMGB1 Promotes the Migration of Cord Blood CD34 -LRB- + -RRB- Cells via SDF-1 / CXCR-4 Axis -RSB- .
12532104	0	CXCR1	75,80	Bradykinin	0,10	CXCR1	Bradykinin	3577	3827	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic_rhinitis .
21850025	0	CXCR1	96,101	CCR1	83,87	CXCR1	CCR1	3577	1230	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
21850025	0	CXCR1	96,101	CCR10	89,94	CXCR1	CCR10	3577	2826	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
14688334	0	CXCR1	0,5	CD4	6,9	CXCR1	CD4	3577	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CXCR1 + CD4 + T cells in human allergic_disease .
21048114	0	CXCR1	133,138	CD4	21,24	CXCR1	CD4	3577	920	Gene	Gene	induction|nmod|START_ENTITY _|nmod|induction _|dep|cells cells|dep|Enrichment Enrichment|nmod|END_ENTITY	Enrichment of Foxp3 + CD4 regulatory T cells in migrated_T cells to IL-6 - _ and_IL-8-expressing tumors through predominant induction of CXCR1 by IL-6 .
15294933	0	CXCR1	47,52	CD8	71,74	CXCR1	CD8	3577	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Cutting edge : expression of chemokine receptor CXCR1 on human effector CD8 + T cells .
16081690	0	CXCR1	25,30	CD8	6,9	CXCR1	CD8	3577	925	Gene	Gene	store|dobj|START_ENTITY +|ccomp|store +|nsubj|END_ENTITY	Human CD8 + T cells store CXCR1 in a distinct intracellular compartment and up-regulate it rapidly to the cell surface upon activation .
12051749	0	CXCR1	68,73	CXCL8	0,5	CXCR1	CXCL8	3577	3576	Gene	Gene	binding|nmod|START_ENTITY ligand|xcomp|binding K11R/G31P|ccomp|ligand K11R/G31P|nsubj|END_ENTITY	CXCL8 -LRB- -LRB- 3-73 -RRB- -RRB- K11R/G31P antagonizes ligand binding to the neutrophil CXCR1 and CXCR2 receptors and cellular responses to CXCL8/IL -8 .
15579377	0	CXCR1	60,65	CXCL8	0,5	CXCR1	CXCL8	3577	3576	Gene	Gene	pathway|compound|START_ENTITY modulates|nmod|pathway modulates|nsubj|END_ENTITY	CXCL8 modulates human intestinal epithelial cells through a CXCR1 dependent pathway .
15974585	0	CXCR1	42,47	CXCL8	81,86	CXCR1	CXCL8	3577	3576	Gene	Gene	CXC_chemokine_receptor_1|appos|START_ENTITY ligands|nsubj|CXC_chemokine_receptor_1 ligands|nmod|inhibitors inhibitors|compound|END_ENTITY	2-Arylpropionic CXC_chemokine_receptor_1 -LRB- CXCR1 -RRB- ligands as novel noncompetitive CXCL8 inhibitors .
17197447	0	CXCR1	7,12	CXCL8	72,77	CXCR1	CXCR2	227288(Tax:10090)	3579	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Murine CXCR1 is a functional receptor for GCP-2 / CXCL6 and interleukin-8 / CXCL8 .
17876799	0	CXCR1	25,30	CXCL8	53,58	CXCR1	CXCL8	3577	3576	Gene	Gene	studies|nmod|START_ENTITY studies|appos|receptor receptor|nmod|END_ENTITY	Computational studies of CXCR1 , the receptor of IL-8 / CXCL8 , using molecular dynamics and electrostatics .
19667085	0	CXCR1	42,47	CXCL8	61,66	CXCR1	CXCL8	3577	3576	Gene	Gene	activation|nmod|START_ENTITY Differential|dobj|activation Differential|nmod|monomer monomer|compound|END_ENTITY	Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer .
26689258	0	CXCR1	101,106	CXCL8	22,27	CXCR1	CXCL8	3577	3576	Gene	Gene	interactions|nmod|START_ENTITY inhibit|dobj|interactions inhibit|nsubj|Peptides Peptides|acl|derived derived|nmod|END_ENTITY	Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1 .
26689258	0	CXCR1	101,106	CXCL8	64,69	CXCR1	CXCL8	3577	3576	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	Peptides derived from CXCL8 based on in silico analysis inhibit CXCL8 interactions with its receptor CXCR1 .
21850025	0	CXCR1	96,101	CXCR2	103,108	CXCR1	CXCR2	3577	3579	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
16406804	0	CXCR1	38,43	FAK	115,118	CXCR1	FAK	227288(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|dep|mechanisms mechanisms|acl|converge converge|nmod|pathways pathways|compound|END_ENTITY	CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2 : cytoskeleton - and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner .
16406804	0	CXCR1	38,43	FAK	14,17	CXCR1	FAK	227288(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2 : cytoskeleton - and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner .
26065367	0	CXCR1	73,78	FOXC1	36,41	CXCR1	FOXC1	227288(Tax:10090)	17300(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Interleukin-8 Induces Expression of FOXC1 to Promote Trans-activation of CXCR1 and CCL2 in Hepatocellular_Carcinoma Cell Lines and Formation of Metastases in Mice .
10588510	0	CXCR1	25,30	IL-8	52,56	CXCR1	IL-8	3577	3576	Gene	Gene	Ca2|compound|START_ENTITY +|nsubj|Ca2 +|nmod|END_ENTITY	CXCR2 stimulation primes CXCR1 -LSB- Ca2 + -RSB- i responses to IL-8 in human neutrophils .
11350788	0	CXCR1	32,37	IL-8	0,4	CXCR1	IL-8	3577	3576	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways .
15252057	0	CXCR1	68,73	IL-8	51,55	CXCR1	IL-8	3577	3576	Gene	Gene	binding|nmod|START_ENTITY receptor|amod|binding receptor|amod|interleukin-8 interleukin-8|dep|END_ENTITY	Dimer_dissociation is essential for interleukin-8 -LRB- IL-8 -RRB- binding to CXCR1 receptor .
16517565	0	CXCR1	109,114	IL-8	73,77	CXCR1	IL-8	3577	3576	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of combined 17beta-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture .
17876799	0	CXCR1	25,30	IL-8	48,52	CXCR1	IL-8	3577	3576	Gene	Gene	studies|nmod|START_ENTITY studies|appos|receptor receptor|nmod|CXCL8 CXCL8|compound|END_ENTITY	Computational studies of CXCR1 , the receptor of IL-8 / CXCL8 , using molecular dynamics and electrostatics .
25081383	0	CXCR1	9,14	IL-8	4,8	CXCR1	IL-8	3577	3576	Gene	Gene	axis|compound|START_ENTITY associated|nsubjpass|axis END_ENTITY|parataxis|associated	The IL-8 / CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic_cancer cases .
9070443	0	CXCR1	85,90	IL-8	0,4	CXCR1	IL-8	3577	3576	Gene	Gene	interactions|nmod|START_ENTITY homodimers|dep|interactions homodimers|compound|END_ENTITY	IL-8 single-chain homodimers and heterodimers : interactions with chemokine receptors CXCR1 , CXCR2 , and DARC .
9725262	0	CXCR1	61,66	IL-8	42,46	CXCR1	IL-8	3577	3576	Gene	Gene	activity|dep|START_ENTITY activity|nmod|type type|compound|END_ENTITY	Expression and functional activity of the IL-8 receptor type CXCR1 and CXCR2 on human mast cells .
10088599	0	CXCR1	22,27	IL-8RA	14,20	CXCR1	IL-8RA	3577	3577	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Regulation of IL-8RA -LRB- CXCR1 -RRB- expression in polymorphonuclear leukocytes by hypoxia/reoxygenation .
11511101	0	CXCR1	62,67	Il-8	0,4	CXCR1	Il-8	3577	3576	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	Il-8 -LRB- -LRB- 3-73 -RRB- -RRB- K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2 .
12738812	0	CXCR1	112,117	Interleukin-8	0,13	CXCR1	Interleukin-8	3577	3576	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1 .
25944115	0	CXCR1	78,83	Interleukin-8	111,124	CXCR1	Interleukin-8	281863(Tax:9913)	280828(Tax:9913)	Gene	Gene	neutrophils|nmod|START_ENTITY generation|nmod|neutrophils genotype|nsubj|generation genotype|dobj|incubation incubation|compound|END_ENTITY	Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 -LRB- IL8RA -RRB- genotype following Interleukin-8 incubation .
25944115	0	CXCR1	78,83	Interleukin-8	111,124	CXCR1	Interleukin-8	281863(Tax:9913)	280828(Tax:9913)	Gene	Gene	neutrophils|nmod|START_ENTITY generation|nmod|neutrophils genotype|nsubj|generation genotype|dobj|incubation incubation|compound|END_ENTITY	Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 -LRB- IL8RA -RRB- genotype following Interleukin-8 incubation .
26065367	0	CXCR1	73,78	Interleukin-8	0,13	CXCR1	Interleukin-8	227288(Tax:10090)	20309(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Interleukin-8 Induces Expression of FOXC1 to Promote Trans-activation of CXCR1 and CCL2 in Hepatocellular_Carcinoma Cell Lines and Formation of Metastases in Mice .
11080597	0	CXCR1	86,91	chemokine_receptor	40,58	CXCR1	chemokine receptor	430652(Tax:9031)	419784(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation and characterization of a new chemokine_receptor gene , the putative chicken CXCR1 .
11113872	0	CXCR1	45,50	interleukin-8	20,33	CXCR1	interleukin-8	3577	3576	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Distribution of the interleukin-8 receptors , CXCR1 and CXCR2 , in inflamed gut tissue .
15252057	0	CXCR1	68,73	interleukin-8	36,49	CXCR1	interleukin-8	3577	3576	Gene	Gene	binding|nmod|START_ENTITY receptor|amod|binding receptor|amod|END_ENTITY	Dimer_dissociation is essential for interleukin-8 -LRB- IL-8 -RRB- binding to CXCR1 receptor .
15652230	0	CXCR1	109,114	interleukin-8	14,27	CXCR1	interleukin-8	3577	3576	Gene	Gene	inhibitor|nmod|START_ENTITY repertaxin|appos|inhibitor Inhibition|nmod|repertaxin Inhibition|nmod|responses responses|amod|END_ENTITY	Inhibition of interleukin-8 -LRB- CXCL8/IL -8 -RRB- responses by repertaxin , a new inhibitor of the chemokine receptors CXCR1 and CXCR2 .
17222184	0	CXCR1	67,72	interleukin-8	34,47	CXCR1	interleukin-8	3577	3576	Gene	Gene	domain|compound|START_ENTITY binding|nmod|domain characterization|amod|binding characterization|nmod|monomer monomer|amod|END_ENTITY	Thermodynamic characterization of interleukin-8 monomer binding to CXCR1 receptor N-terminal domain .
19681642	0	CXCR1	88,93	interleukin-8	49,62	CXCR1	interleukin-8	3577	3576	Gene	Gene	N-domain|compound|START_ENTITY monomer|nmod|N-domain monomer|amod|END_ENTITY	Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain : role of coupled interactions and dynamics .
22019593	0	CXCR1	64,69	interleukin-8	16,29	CXCR1	interleukin-8	3577	3576	Gene	Gene	START_ENTITY|nsubj|Interactions Interactions|nmod|receptor receptor|amod|END_ENTITY	Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy .
24164922	0	CXCR1	119,124	interleukin-8	23,36	CXCR1	interleukin-8	3577	3576	Gene	Gene	cells|nmod|START_ENTITY signalling|nmod|cells autocrine|xcomp|signalling autocrine|nsubj|secretion secretion|nmod|mediates mediates|amod|END_ENTITY	Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1 .
9885232	0	CXCR1	74,79	interleukin-8	21,34	CXCR1	interleukin-8	3577	3576	Gene	Gene	analysis|nmod|START_ENTITY role|dep|analysis role|nmod|END_ENTITY	The biologic role of interleukin-8 : functional analysis and expression of CXCR1 and CXCR2 on human eosinophils .
22262769	0	CXCR1	52,57	p17	21,24	CXCR1	p17	3577	653820	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation .
22904195	0	CXCR1	71,76	p17	21,24	CXCR1	p17	3577	653820	Gene	Gene	angiogenesis|nmod|START_ENTITY promotes|dobj|angiogenesis promotes|nsubj|END_ENTITY	HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2 .
25121556	0	CXCR1	2,7	p17	47,50	CXCR1	p17	3577	653820	Gene	Gene	haplotype|compound|START_ENTITY hampers|nsubj|haplotype hampers|xcomp|activity activity|amod|END_ENTITY	A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity .
21850025	0	CXCR2	103,108	CCR1	83,87	CXCR2	CCR1	3579	1230	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
21850025	0	CXCR2	103,108	CCR10	89,94	CXCR2	CCR10	3579	2826	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
25172501	0	CXCR2	67,72	CD74	62,66	CXCR2	CD74	3579	972	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Macrophage_migration_inhibitory_factor triggers chemotaxis of CD74 + CXCR2 + NKT cells in chemically induced IFN-y-mediated skin_inflammation .
26497045	0	CXCR2	50,55	CXC-chemokine_receptor_2	24,48	CXCR2	CXC-chemokine receptor 2	3579	3579	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The prognostic value of CXC-chemokine_receptor_2 -LRB- CXCR2 -RRB- in gastric_cancer patients .
21850025	0	CXCR2	103,108	CXCR1	96,101	CXCR2	CXCR1	3579	3577	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Autocrine regulation of re-epithelialization after wounding by chemokine receptors CCR1 , CCR10 , CXCR1 , CXCR2 , and CXCR3 .
10588510	0	CXCR2	0,5	IL-8	52,56	CXCR2	IL-8	3579	3576	Gene	Gene	Ca2|compound|START_ENTITY +|nsubj|Ca2 +|nmod|END_ENTITY	CXCR2 stimulation primes CXCR1 -LSB- Ca2 + -RSB- i responses to IL-8 in human neutrophils .
24883303	0	CXCR2	43,48	IL-8	38,42	CXCR2	IL-8	3579	3576	Gene	Gene	axis|nummod|START_ENTITY END_ENTITY|dep|axis	Immunohistochemical analysis of IL-6 , IL-8 / CXCR2 axis , Tyr p-STAT-3 , and SOCS-3 in lymph nodes from patients with chronic_lymphocytic_leukemia : correlation between microvascular characteristics and prognostic significance .
26603204	0	CXCR2	89,94	Interleukin_10	126,140	CXCR2	Interleukin 10	12765(Tax:10090)	16153(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|dep|END_ENTITY	Toll-like_Receptor_4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin_10 During Intra-abdominal_Sepsis .
24098448	0	CXCR2	108,113	NHERF1	154,160	CXCR2	NHERF1	3579	9368	Gene	Gene	structure|nmod|START_ENTITY revealed|nmod|structure revealed|nmod|domain domain|nmod|END_ENTITY	Structural insights into neutrophilic migration revealed by the crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1 .
24768637	0	CXCR2	83,88	NHERF1	25,31	CXCR2	NHERF1	3579	9368	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization .
19446732	0	CXCR2	108,113	chemokine_receptor	20,38	CXCR2	chemokine receptor	3579	7852	Gene	Gene	chemosynapse|dep|START_ENTITY define|xcomp|chemosynapse approach|xcomp|define approach|nsubj|Characterization Characterization|nmod|proteins proteins|amod|END_ENTITY	Characterization of chemokine_receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 `` chemosynapse '' .
19446732	0	CXCR2	39,44	chemokine_receptor	20,38	CXCR2	chemokine receptor	3579	7852	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Characterization of chemokine_receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 `` chemosynapse '' .
11180010	0	CXCR2	151,156	interleukin-8	137,150	CXCR2	interleukin-8	3579	3576	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation , downregulation of the epidermal interleukin-8 / CXCR2 pathway and normalization of keratinocyte maturation .
12628493	0	CXCR2	166,171	interleukin-8	50,63	CXCR2	interleukin-8	3579	3576	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|interactions interactions|nmod|END_ENTITY	Characterization of the molecular interactions of interleukin-8 -LRB- CXCL8 -RRB- , growth related oncogen alpha -LRB- CXCL1 -RRB- and a non-peptide antagonist -LRB- SB_225002 -RRB- with the human CXCR2 .
17030560	0	CXCR2	41,46	interleukin-8	17,30	CXCR2	interleukin-8	3579	3576	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Exercise induces interleukin-8 receptor -LRB- CXCR2 -RRB- expression in human skeletal muscle .
23029099	0	CXCR2	89,94	interleukin-8	27,40	CXCR2	interleukin-8	3579	3576	Gene	Gene	permeability|nmod|START_ENTITY induces|dobj|permeability induces|nsubj|Glioblastoma Glioblastoma|amod|END_ENTITY	Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2 .
12496258	0	CXCR2	112,117	interleukin_8	22,35	CXCR2	interleukin 8	3579	3576	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|nmod|END_ENTITY	Angiogenic effects of interleukin_8 -LRB- CXCL8 -RRB- in human intestinal microvascular endothelial cells are mediated by CXCR2 .
18505935	0	CXCR2	119,124	keratin-14	69,79	CXCR2	keratin-14	12765(Tax:10090)	16664(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Short tail with skin_lesion phenotype occurs in transgenic_mice with keratin-14 promoter-directed expression of mutant CXCR2 .
10201891	0	CXCR3	106,111	6Ckine	119,125	CXCR3	6Ckine	2833	6366	Gene	Gene	signaling|nmod|START_ENTITY Cutting|parataxis|signaling Cutting|parataxis|ligand ligand|nsubj|END_ENTITY	Cutting edge : species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3 : human 6Ckine is not a ligand for the human or mouse CXCR3_receptors .
10201891	0	CXCR3	106,111	6Ckine	54,60	CXCR3	6Ckine	2833	6366	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|specificity specificity|nmod|END_ENTITY	Cutting edge : species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3 : human 6Ckine is not a ligand for the human or mouse CXCR3_receptors .
9653165	0	CXCR3	57,62	6Ckine	17,23	CXCR3	6Ckine	12766(Tax:10090)	18829(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3 .
18811584	0	CXCR3	137,142	CCL27	111,116	CXCR3	CCL27	2833	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CXCR3	137,142	CCR4	125,129	CXCR3	CCR4	2833	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
16455991	0	CXCR3	19,24	CCR5	80,84	CXCR3	CCR5	2833	1234	Gene	Gene	START_ENTITY|parataxis|dependent dependent|nmod|cholesterol cholesterol|amod|END_ENTITY	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
18811584	0	CXCR3	137,142	CCR5	131,135	CXCR3	CCR5	2833	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
22079021	0	CXCR3	90,95	CCR5	104,108	CXCR3	CCR5	2833	1234	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	T lymphocyte recruitment into renal_cell_carcinoma tissue : a role for chemokine receptors CXCR3 , CXCR6 , CCR5 , and CCR6 .
25180533	0	CXCR3	0,5	CCR5	8,12	CXCR3	CCR5	2833	1234	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CXCR3 CCR5 T cells and autoimmune_diseases : guilty as charged ?
20042588	0	CXCR3	32,37	CCR6	38,42	CXCR3	CCR6	2833	1235	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Peripheral blood CCR4 + CCR6 + and CXCR3 + CCR6 + CD4 + T cells are highly permissive to HIV-1_infection .
23358848	0	CXCR3	134,139	CCR6	140,144	CXCR3	CCR6	2833	1235	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Memory_T cells in latent Mycobacterium_tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3 + CCR6 + Th1 subset .
24890729	0	CXCR3	64,69	CCR6	59,63	CXCR3	CCR6	2833	1235	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-1b promotes the differentiation of polyfunctional human CCR6 + CXCR3 + Th1/17 cells that are specific for pathogenic and commensal microbes .
26807971	0	CXCR3	37,42	CCR6	43,47	CXCR3	CCR6	2833	1235	Gene	Gene	DNA|nmod|START_ENTITY Persistence|nmod|DNA +|nsubj|Persistence +|dobj|T-cells T-cells|compound|END_ENTITY	Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4 + T-cells in HIV-infected individuals on antiretroviral therapy .
19609979	0	CXCR3	10,15	CD122	62,67	CXCR3	CD122	12766(Tax:10090)	16185(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|dobj|function function|nmod|Treg Treg|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
12960302	0	CXCR3	0,5	CD4	41,44	CXCR3	CD4	2833	920	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|pathway pathway|nmod|differentiation differentiation|compound|END_ENTITY	CXCR3 is induced early on the pathway of CD4 + T cell differentiation and bridges central and peripheral functions .
15265673	0	CXCR3	0,5	CD4	12,15	CXCR3	CD4	2833	920	Gene	Gene	marks|nsubj|START_ENTITY marks|dobj|lymphocytes lymphocytes|compound|END_ENTITY	CXCR3 marks CD4 + memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer .
15708587	0	CXCR3	0,5	CD4	39,42	CXCR3	CD4	2833	920	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|recruitment recruitment|compound|END_ENTITY	CXCR3 , IP-10 , and Mig are required for CD4 + T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance .
15884054	0	CXCR3	0,5	CD4	125,128	CXCR3	CD4	84475(Tax:10116)	24932(Tax:10116)	Gene	Gene	required|nsubjpass|START_ENTITY required|xcomp|dermal dermal|nmod|subsets subsets|compound|END_ENTITY	CXCR3 is required for migration to dermal inflammation by normal and in vivo activated T cells : differential requirements by CD4 and CD8 memory subsets .
16427705	0	CXCR3	50,55	CD4	59,62	CXCR3	CD4	2833	920	Gene	Gene	chemokine|dobj|START_ENTITY chemokine|nmod|cells cells|compound|END_ENTITY	Altered expression of Th1-type chemokine receptor CXCR3 on CD4 + T cells in myasthenia_gravis patients .
16455991	0	CXCR3	19,24	CD4	50,53	CXCR3	CD4	2833	920	Gene	Gene	START_ENTITY|parataxis|dependent dependent|nsubj|signaling signaling|compound|END_ENTITY	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
16479546	0	CXCR3	23,28	CD4	32,35	CXCR3	CD4	12766(Tax:10090)	12504(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|+ +|compound|END_ENTITY	Differential roles for CXCR3 in CD4 + and CD8 + T cell trafficking following viral_infection of the CNS .
16670334	0	CXCR3	30,35	CD4	59,62	CXCR3	CD4	12766(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|liver_damage liver_damage|compound|END_ENTITY	Fas ligand is responsible for CXCR3 chemokine induction in CD4 + T cell-dependent liver_damage .
17374135	0	CXCR3	147,152	CD4	154,157	CXCR3	CD4	2833	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chemokine and chemokine_receptor analysis reveals elevated interferon-inducible_protein-10 _ -LRB- IP -RRB- -10 / CXCL10 levels and increased number of CCR5 + and CXCR3 + CD4 T cells in synovial fluid of patients with enthesitis-related_arthritis -LRB- ERA -RRB- .
19116922	0	CXCR3	0,5	CD4	6,9	CXCR3	CD4	2833	920	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	CXCR3 + CD4 + T cells are enriched in inflamed kidneys and urine and provide a new biomarker for acute_nephritis flares in systemic_lupus_erythematosus patients .
19293635	0	CXCR3	22,27	CD4	39,42	CXCR3	CD4	2833	920	Gene	Gene	CCR4|compound|START_ENTITY addition|nmod|CCR4 enhances|nsubj|addition enhances|nsubj|cells cells|amod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
19423402	0	CXCR3	0,5	CD4	31,34	CXCR3	CD4	2833	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	CXCR3 expression on peripheral CD4 + T cells as a predictive marker of response to treatment in chronic hepatitis_C .
19734208	0	CXCR3	0,5	CD4	40,43	CXCR3	CD4	12766(Tax:10090)	12504(Tax:10090)	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|migration migration|compound|END_ENTITY	CXCR3 directs antigen-specific effector CD4 + T cell migration to the lung during parainfluenza virus infection .
21357438	0	CXCR3	10,15	CD4	30,33	CXCR3	CD4	2833	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Decreased CXCR3 expression in CD4 + T cells exposed to asbestos or derived from asbestos-exposed patients .
21538345	0	CXCR3	82,87	CD4	17,20	CXCR3	CD4	2833	920	Gene	Gene	express|dobj|START_ENTITY express|nsubj|Subsets Subsets|nmod|END_ENTITY	Subsets of human CD4 -LRB- + -RRB- regulatory T cells express the peripheral homing receptor CXCR3 .
22670785	0	CXCR3	41,46	CD4	25,28	CXCR3	CD4	2833	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripherally circulating CD4 FOXP3 CXCR3 T regulatory cells correlate with renal allograft function .
23012327	0	CXCR3	41,46	CD4	48,51	CXCR3	CD4	2833	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chemokine-mediated tissue recruitment of CXCR3 + CD4 + T cells plays a major role in the pathogenesis of chronic GVHD .
23123063	0	CXCR3	0,5	CD4	72,75	CXCR3	CD4	12766(Tax:10090)	12504(Tax:10090)	Gene	Gene	interactions|nummod|START_ENTITY optimize|nsubj|interactions optimize|ccomp|helper helper|nsubj|T T|compound|END_ENTITY	CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4 + T helper 1 cell differentiation .
26183767	0	CXCR3	4,9	CD4	0,3	CXCR3	CD4	2833	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CXCR3 + T cells and plasmacytoid dendritic cells drive accelerated atherosclerosis associated with systemic_lupus_erythematosus .
26657511	0	CXCR3	30,35	CD4	76,79	CXCR3	CD4	12766(Tax:10090)	12504(Tax:10090)	Gene	Gene	pathways|nmod|START_ENTITY control|nsubj|pathways control|dobj|development development|nmod|subsets subsets|compound|END_ENTITY	Biased signaling pathways via CXCR3 control the development and function of CD4 + T cell subsets .
26807971	0	CXCR3	37,42	CD4	55,58	CXCR3	CD4	2833	920	Gene	Gene	DNA|nmod|START_ENTITY Persistence|nmod|DNA +|nsubj|Persistence +|dobj|T-cells T-cells|compound|END_ENTITY	Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4 + T-cells in HIV-infected individuals on antiretroviral therapy .
11918674	0	CXCR3	42,47	CD8	73,76	CXCR3	CD8	2833	925	Gene	Gene	Requirement|nmod|START_ENTITY chemokine|nsubj|Requirement chemokine|xcomp|signalling signalling|nmod|activation activation|compound|END_ENTITY	Requirement of the IFN-alpha/beta-induced CXCR3 chemokine signalling for CD8 + T cell activation .
17553894	0	CXCR3	10,15	CD8	17,20	CXCR3	CD8	2833	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Decreased CXCR3 + CD8 T cells in advanced human immunodeficiency_virus_infection suggest that a homing defect contributes to cytotoxic T-lymphocyte_dysfunction .
17785868	0	CXCR3	19,24	CD8	60,63	CXCR3	CD8	2833	925	Gene	Gene	Down-modulation|nmod|START_ENTITY surface|nsubj|Down-modulation surface|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	Down-modulation of CXCR3 surface expression and function in CD8 + T cells from cutaneous_T_cell_lymphoma patients .
19609979	0	CXCR3	10,15	CD8	58,61	CXCR3	CD8	12766(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|dobj|function function|nmod|Treg Treg|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
19609979	0	CXCR3	10,15	CD8	6,9	CXCR3	CD8	12766(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD8 + CXCR3 + T cells have the same function as murine CD8 + CD122 + Treg .
21518913	0	CXCR3	33,38	CD8	98,101	CXCR3	CD8	2833	925	Gene	Gene	Expression|nmod|START_ENTITY affects|nsubj|Expression affects|dobj|balance balance|nmod|generation generation|compound|END_ENTITY	Expression of chemokine receptor CXCR3 on T cells affects the balance between effector and memory CD8 T-cell generation .
22111598	0	CXCR3	0,5	CD8	40,43	CXCR3	CD8	2833	925	Gene	Gene	Expression|compound|START_ENTITY Elevated|nsubj|Expression Elevated|nmod|Lymphocytes Lymphocytes|compound|END_ENTITY	CXCR3 Expression Elevated on Peripheral CD8 -LRB- + -RRB- Lymphocytes from HIV/HCV _ Coinfected Individuals .
22719212	0	CXCR3	99,104	CD8	106,109	CXCR3	CD8	2833	925	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Treatment with transcatheter arterial chemoembolization induces an increase of the L-selectin -LRB- low -RRB- CXCR3 + CD8 + T cell subset in patients with hepatocellular_carcinoma .
23065152	0	CXCR3	52,57	CD8	0,3	CXCR3	CD8	2833	925	Gene	Gene	ligands|nummod|START_ENTITY migration|nmod|ligands induce|dobj|migration induce|nsubj|cells cells|compound|END_ENTITY	CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines .
23643635	0	CXCR3	16,21	CD8	36,39	CXCR3	CD8	2833	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of CXCR3 expression on CD8 + T cells due to the pervasive influence of chronic_hepatitis_B and C_virus infection .
24377099	0	CXCR3	71,76	CD8	147,150	CXCR3	CD8	2833	925	Gene	Gene	increases|dobj|START_ENTITY increases|dobj|cells cells|compound|END_ENTITY	Peptide vaccination in Montanide adjuvant induces and GM-CSF increases CXCR3 and cutaneous lymphocyte antigen expression by tumor antigen-specific CD8 T cells .
25769612	0	CXCR3	0,5	CD8	39,42	CXCR3	CD8	2833	925	Gene	Gene	receptor|nummod|START_ENTITY enables|nsubj|receptor enables|ccomp|T T|nsubj|END_ENTITY	CXCR3 chemokine receptor enables local CD8 -LRB- + -RRB- T cell migration for the destruction of virus-infected cells .
11523046	0	CXCR3	27,32	CXCL10	54,60	CXCR3	CXCL10	2833	3627	Gene	Gene	targeting|compound|START_ENTITY expression|nmod|targeting chemokines|nsubj|expression chemokines|dobj|END_ENTITY	Differential expression of CXCR3 targeting chemokines CXCL10 , CXCL9 , and CXCL11 in different types of skin_inflammation .
12571234	0	CXCR3	0,5	CXCL10	56,62	CXCR3	CXCL10	12766(Tax:10090)	15945(Tax:10090)	Gene	Gene	START_ENTITY|dep|sites sites|nmod|IP-10 IP-10|appos|END_ENTITY	CXCR3 and heparin binding sites of the chemokine IP-10 -LRB- CXCL10 -RRB- .
12884299	0	CXCR3	48,53	CXCL10	77,83	CXCR3	CXCL10	2833	3627	Gene	Gene	regulated|nmod|START_ENTITY regulated|dobj|CXCL9 CXCL9|nummod|END_ENTITY	CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9 , CXCL10 and CXCL11 .
15081542	0	CXCR3	41,46	CXCL10	63,69	CXCR3	CXCL10	2833	3627	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of the chemokine_receptor CXCR3 and its ligand , CXCL10 , in human breast_adenocarcinoma cell lines .
15194051	0	CXCR3	107,112	CXCL10	60,66	CXCR3	CXCL10	2833	3627	Gene	Gene	depends|nmod|START_ENTITY depends|nsubj|activity activity|nmod|END_ENTITY	The angiostatic activity of interferon-inducible protein-10 / CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan .
15885315	0	CXCR3	24,29	CXCL10	148,154	CXCR3	CXCL10	2833	3627	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Increased expression of CXCR3 and CCR5 on memory CD4 + T-cells migrating into the cerebrospinal fluid of patients with neuroborreliosis : the role of CXCL10 and CXCL11 .
16547260	0	CXCR3	29,34	CXCL10	0,6	CXCR3	CXCL10	12766(Tax:10090)	15945(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	CXCL10 is the key ligand for CXCR3 on CD8 + effector T cells involved in immune surveillance of the lymphocytic_choriomeningitis_virus-infected central nervous system .
16934957	0	CXCR3	79,84	CXCL10	18,24	CXCR3	CXCL10	2833	3627	Gene	Gene	receptor|appos|START_ENTITY expression|nsubj|receptor activates|ccomp|expression activates|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of CXCL10 in human prostate LNCaP cells activates its receptor -LRB- CXCR3 -RRB- expression and inhibits cell proliferation .
18533024	0	CXCR3	73,78	CXCL10	0,6	CXCR3	CXCL10	12766(Tax:10090)	15945(Tax:10090)	Gene	Gene	+|compound|START_ENTITY recruitment|nmod|+ assist|nmod|recruitment T|ccomp|assist T|nsubj|+ +|compound|END_ENTITY	CXCL10 + T cells and NK cells assist in the recruitment and activation of CXCR3 + and CXCL11 + leukocytes during Mycobacteria-enhanced colitis .
20856926	0	CXCR3	67,72	CXCL10	0,6	CXCR3	CXCL10	12766(Tax:10090)	15945(Tax:10090)	Gene	Gene	proliferation|nmod|START_ENTITY inhibit|dobj|proliferation inhibit|nsubj|END_ENTITY	CXCL10 can inhibit endothelial cell proliferation independently of CXCR3 .
21895630	0	CXCR3	129,134	CXCL10	85,91	CXCR3	CXCL10	2833	3627	Gene	Gene	ligands|nmod|START_ENTITY ligands|nsubj|END_ENTITY	Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3 .
22287719	0	CXCR3	129,134	CXCL10	103,109	CXCR3	CXCL10	2833	3627	Gene	Gene	+|compound|START_ENTITY attract|dobj|+ attract|nsubj|END_ENTITY	Adjuvant immunotherapy of experimental_autoimmune_encephalomyelitis : immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3 + CXCR6 + and myelin-specific T cells to the draining lymph nodes rather than the central nervous system .
26604174	0	CXCR3	54,59	CXCL10	47,53	CXCR3	CXCL10	2833	3627	Gene	Gene	Axis|compound|START_ENTITY Diabetes|dep|Axis Back|parataxis|Diabetes Back|parataxis|END_ENTITY	Back From the Brink : The Uses of Targeting the CXCL10 : CXCR3 Axis in Type 1 Diabetes .
12444109	0	CXCR3	31,36	CXCL12	64,70	CXCR3	CXCL12	2833	6387	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation .
12932287	0	CXCR3	5,10	CXCL9	61,66	CXCR3	CXCL9	2833	4283	Gene	Gene	expression|compound|START_ENTITY associated|nsubj|expression associated|nmod|expression expression|compound|END_ENTITY	High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid_arthritis .
22079021	0	CXCR3	90,95	CXCR6	97,102	CXCR3	CXCR6	2833	10663	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	T lymphocyte recruitment into renal_cell_carcinoma tissue : a role for chemokine receptors CXCR3 , CXCR6 , CCR5 , and CCR6 .
22287719	0	CXCR3	129,134	CXCR6	135,140	CXCR3	CXCR6	2833	10663	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Adjuvant immunotherapy of experimental_autoimmune_encephalomyelitis : immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3 + CXCR6 + and myelin-specific T cells to the draining lymph nodes rather than the central nervous system .
26538397	0	CXCR3	19,24	FLI1	0,4	CXCR3	FLI1	12766(Tax:10090)	14247(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain .
22670785	0	CXCR3	41,46	FOXP3	32,37	CXCR3	FOXP3	2833	50943	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripherally circulating CD4 FOXP3 CXCR3 T regulatory cells correlate with renal allograft function .
26273136	0	CXCR3	21,26	Foxp3	42,47	CXCR3	Foxp3	12766(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY Effect|nmod|CD4 CD25|nsubj|Effect CD25|xcomp|Cells Cells|nsubj|END_ENTITY	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
15122750	0	CXCR3	18,23	I-TAC	31,36	CXCR3	I-TAC	2833	6373	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis_C and its correlation with hepatic_inflammation .
18811584	0	CXCR3	137,142	IFN-beta	161,169	CXCR3	IFN-beta	2833	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
12115663	0	CXCR3	36,41	IFN-gamma	146,155	CXCR3	IFN-gamma	2833	3458	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|dependence dependence|nmod|stimulation stimulation|amod|END_ENTITY	Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells : dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation .
14498985	0	CXCR3	32,37	IFN-gamma	14,23	CXCR3	IFN-gamma	699438(Tax:9544)	574282(Tax:9544)	Gene	Gene	chemokines|nummod|START_ENTITY induced|dobj|chemokines induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of IFN-gamma induced CXCR3 agonist chemokines and compartmentalization of CXCR3 + cells in the periphery and lymph nodes of rhesus_macaques during simian immunodeficiency_virus_infection and acquired_immunodeficiency_syndrome .
14498985	0	CXCR3	85,90	IFN-gamma	14,23	CXCR3	IFN-gamma	699438(Tax:9544)	574282(Tax:9544)	Gene	Gene	cells|nummod|START_ENTITY induced|nmod|cells induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of IFN-gamma induced CXCR3 agonist chemokines and compartmentalization of CXCR3 + cells in the periphery and lymph nodes of rhesus_macaques during simian immunodeficiency_virus_infection and acquired_immunodeficiency_syndrome .
16547278	0	CXCR3	83,88	IFN-gamma	59,68	CXCR3	IFN-gamma	12766(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Severe_disease , unaltered leukocyte migration , and reduced IFN-gamma production in CXCR3 - / - mice with experimental autoimmune encephalomyelitis .
10903763	0	CXCR3	0,5	IFN-gamma-inducible_protein-10	56,86	CXCR3	IFN-gamma-inducible protein-10	2833	3627	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	CXCR3 expression and activation of eosinophils : role of IFN-gamma-inducible_protein-10 and monokine_induced_by_IFN-gamma .
26732675	0	CXCR3	20,25	IL-10	0,5	CXCR3	IL-10	12766(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites .
24890729	0	CXCR3	64,69	IL-1b	0,5	CXCR3	IL-1b	2833	3553	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells promotes|dobj|differentiation promotes|nsubj|END_ENTITY	IL-1b promotes the differentiation of polyfunctional human CCR6 + CXCR3 + Th1/17 cells that are specific for pathogenic and commensal microbes .
11029363	0	CXCR3	79,84	IP-10	15,20	CXCR3	IP-10	2833	3627	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|dep|cells	CXC chemokines IP-10 and mig expression and direct migration of pulmonary CD8 + / CXCR3 + T cells in the lungs of patients with HIV_infection_and_T-cell_alveolitis .
18811584	0	CXCR3	137,142	IP-10	118,123	CXCR3	IP-10	2833	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
14578618	0	CXCR3	0,5	IP10	32,36	CXCR3	IP10	2833	3627	Gene	Gene	chemokine|nsubj|START_ENTITY chemokine|dobj|interaction interaction|compound|END_ENTITY	CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary_artery_disease .
9541591	0	CXCR3	23,28	IP10	127,131	CXCR3	IP10	2833	3627	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig .
22719212	0	CXCR3	99,104	L-selectin	83,93	CXCR3	L-selectin	2833	6402	Gene	Gene	subset|compound|START_ENTITY subset|amod|END_ENTITY	Treatment with transcatheter arterial chemoembolization induces an increase of the L-selectin -LRB- low -RRB- CXCR3 + CD8 + T cell subset in patients with hepatocellular_carcinoma .
18980207	0	CXCR3	101,106	MIG	30,33	CXCR3	MIG	2833	4283	Gene	Gene	+|compound|START_ENTITY dendritic_cells|nmod|+ include|dobj|dendritic_cells cells|acl:relcl|include expression|nmod|cells expression|appos|END_ENTITY	Abundant expression of CXCL9 -LRB- MIG -RRB- by stromal cells that include dendritic_cells and accumulation of CXCR3 + T cells in lymphocyte-rich gastric_carcinoma .
18811584	0	CXCR3	137,142	MIP-1alpha	99,109	CXCR3	MIP-1alpha	2833	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
11600578	0	CXCR3	94,99	Mig	78,81	CXCR3	Mig	2833	4283	Gene	Gene	+|compound|START_ENTITY lymphocytes|nummod|+ END_ENTITY|dobj|lymphocytes	Thyrocytes from autoimmune_thyroid_disorders produce the chemokines IP-10 and Mig and attract CXCR3 + lymphocytes .
18811584	0	CXCR3	137,142	PD1	144,147	CXCR3	PD1	2833	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	CXCR3	137,142	PDL2	149,153	CXCR3	PDL2	2833	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
14657006	0	CXCR3	40,45	Th1	62,65	CXCR3	Th1	2833	51497	Gene	Gene	loop|compound|START_ENTITY loop|amod|END_ENTITY	Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop .
15668916	0	CXCR3	0,5	Th1	33,36	CXCR3	Th1	12766(Tax:10090)	57314(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mount|nsubj|mice mount|dobj|response response|amod|END_ENTITY	CXCR3 - / - mice mount an efficient Th1 response but fail to control Leishmania_major_infection .
19293635	0	CXCR3	22,27	Th1	46,49	CXCR3	Th1	2833	51497	Gene	Gene	CCR4|compound|START_ENTITY addition|nmod|CCR4 enhances|nsubj|addition enhances|nsubj|cells cells|amod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
19734217	0	CXCR3	0,5	Th1	21,24	CXCR3	Th1	12766(Tax:10090)	57314(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	CXCR3 mediates renal Th1 and Th17 immune response in murine lupus_nephritis .
21789162	0	CXCR3	49,54	Th1	56,59	CXCR3	Th1	12766(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Peritoneal cavity is dominated by IFNy-secreting CXCR3 + Th1 cells .
23358848	0	CXCR3	134,139	Th1	146,149	CXCR3	Th1	2833	51497	Gene	Gene	subset|compound|START_ENTITY subset|amod|END_ENTITY	Memory_T cells in latent Mycobacterium_tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3 + CCR6 + Th1 subset .
12688353	0	CXCR3	33,38	mig	55,58	CXCR3	mig	2833	4283	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of chemokine receptor CXCR3 and its ligand , mig , in gastric and thyroid marginal zone_lymphomas .
11554781	0	CXCR3_receptor	80,94	B_cell-attracting_chemokine_1	6,35	CXCR3 receptor	B cell-attracting chemokine 1	2833	10563	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	Human B_cell-attracting_chemokine_1 -LRB- BCA-1 ; CXCL13 -RRB- is an agonist for the human CXCR3_receptor .
23290300	0	CXCR4	108,113	ABCG2	102,107	CXCR4	ABCG2	60628(Tax:10116)	312382(Tax:10116)	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133 + ABCG2 + CXCR4 + mesenchymal stem cells : development of autologous cell-based therapeutics for traumatic_brain_injury .
19379577	0	CXCR4	18,23	AC133	56,61	CXCR4	AC133	7852	8842	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effects of SDF-1 / CXCR4 on the chemotaxis of cord blood AC133 -LRB- + -RRB- cells -RSB- .
20568229	0	CXCR4	15,20	CCL18	34,39	CXCR4	CCL18	7852	6362	Gene	Gene	responses|nummod|START_ENTITY responses|nmod|END_ENTITY	Attenuation of CXCR4 responses by CCL18 in acute_lymphocytic_leukemia B cells .
16179731	0	CXCR4	43,48	CCR5	62,66	CXCR4	CCR5	7852	1234	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells .
10878344	0	CXCR4	58,63	CCR7	83,87	IL-15	CCR7	3600	1236	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|memory memory|compound|END_ENTITY	Cytokines and cell surface molecules independently induce CXCR4 expression on CD4 + CCR7 + human memory T cells .
22350183	0	CXCR4	42,47	CCR7	49,53	CXCR4	CCR7	7852	1236	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Overexpression of the chemokine receptors CXCR4 , CCR7 , CCR9 , and CCR10 in human primary cutaneous_melanoma : a potential prognostic value for CCR7 and CCR10 ?
17765649	0	CXCR4	158,163	CD133	28,33	CXCR4	CD133	7852	8842	Gene	Gene	modulation|nmod|START_ENTITY related|nmod|modulation expression|dep|related consumption|nmod|expression stem|nmod|consumption stem|nsubj|Mobilization Mobilization|nmod|+ +|compound|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
23290300	0	CXCR4	108,113	CD133	95,100	CXCR4	CD133	60628(Tax:10116)	60357(Tax:10116)	Gene	Gene	mesenchymal|compound|START_ENTITY mesenchymal|compound|END_ENTITY	Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133 + ABCG2 + CXCR4 + mesenchymal stem cells : development of autologous cell-based therapeutics for traumatic_brain_injury .
26141860	0	CXCR4	45,50	CD133	38,43	CXCR4	CD133	7852	8842	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Microenvironment-Modulated Metastatic CD133 + / CXCR4 + / EpCAM - Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis .
26466742	0	CXCR4	14,19	CD133	42,47	CXCR4	CD133	7852	8842	Gene	Gene	Expression|nmod|START_ENTITY blood-derived|nsubj|Expression blood-derived|dobj|cells cells|nummod|END_ENTITY	Expression of CXCR4 in cord blood-derived CD133 + cells treated with platelet micro-particles .
12899713	0	CXCR4	0,5	CD184	27,32	CXCR4	CD184	7852	7852	Gene	Gene	receptors|nummod|START_ENTITY receptors|appos|END_ENTITY	CXCR4 chemokine receptors -LRB- CD184 -RRB- and alpha4beta1 integrins mediate spontaneous migration of human CD34 + progenitors and acute_myeloid_leukaemia cells beneath marrow stromal cells -LRB- pseudoemperipolesis -RRB- .
11756152	0	CXCR4	50,55	CD30	0,4	CXCR4	CD30	7852	943	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 .
10381499	0	CXCR4	28,33	CD34	6,10	CXCR4	CD34	7852	947	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	Human CD34 -LRB- + -RRB- cells express CXCR4 and its ligand stromal_cell-derived_factor-1 .
12004084	0	CXCR4	23,28	CD34	18,22	CXCR4	CD34	7852	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immature leukemic CD34 + CXCR4 + cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1 .
12899713	0	CXCR4	0,5	CD34	99,103	CXCR4	CD34	7852	947	Gene	Gene	receptors|nummod|START_ENTITY mediate|nsubj|receptors mediate|dobj|migration migration|nmod|progenitors progenitors|compound|END_ENTITY	CXCR4 chemokine receptors -LRB- CD184 -RRB- and alpha4beta1 integrins mediate spontaneous migration of human CD34 + progenitors and acute_myeloid_leukaemia cells beneath marrow stromal cells -LRB- pseudoemperipolesis -RRB- .
15020611	0	CXCR4	66,71	CD34	22,26	CXCR4	CD34	7852	947	Gene	Gene	AMD3100|compound|START_ENTITY administration|nmod|AMD3100 cells|nmod|administration cells|nummod|END_ENTITY	Rapid mobilization of CD34 + cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple_myeloma and non-Hodgkin 's _ lymphoma .
15070669	0	CXCR4	18,23	CD34	33,37	CXCR4	CD34	7852	947	Gene	Gene	START_ENTITY|nmod|progenitors progenitors|compound|END_ENTITY	Overexpression of CXCR4 on human CD34 + progenitors increases their proliferation , migration , and NOD/SCID repopulation .
15377464	0	CXCR4	25,30	CD34	63,67	CXCR4	CD34	7852	947	Gene	Gene	molecules|compound|START_ENTITY molecules|nmod|cells cells|compound|END_ENTITY	Pattern of expression of CXCR4 and adhesion molecules by human CD34 + cells from different sources : role in homing efficiency in NOD/SCID mice .
15536192	0	CXCR4	59,64	CD34	74,78	CXCR4	CD34	7852	947	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|cells cells|compound|END_ENTITY	Intracellular localization and constitutive endocytosis of CXCR4 in human CD34 + hematopoietic progenitor cells .
15752146	0	CXCR4	194,199	CD34	41,45	CXCR4	CD34	7852	947	Gene	Gene	antagonist|compound|START_ENTITY stimulated|dobj|antagonist stimulated|nsubj|mobilization mobilization|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Augmented mobilization and collection of CD34 + hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating_factor by single-dose administration of AMD3100 , a CXCR4 antagonist .
16204315	0	CXCR4	53,58	CD34	79,83	CXCR4	CD34	7852	947	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|progenitors progenitors|compound|END_ENTITY	cAMP-induced PKCzeta activation increases functional CXCR4 expression on human CD34 + hematopoietic progenitors .
16247418	0	CXCR4	4,9	CD34	33,37	CXCR4	CD34	7852	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Low CXCR4 membrane expression on CD34 -LRB- + -RRB- cells characterizes cells mobilized to blood .
16267071	0	CXCR4	35,40	CD34	16,20	CXCR4	CD34	7852	947	Gene	Gene	Mobilization|appos|START_ENTITY Mobilization|nmod|END_ENTITY	Mobilization of CD34 -LRB- + -RRB- , CD117 -LRB- + -RRB- , CXCR4 -LRB- + -RRB- , c-met -LRB- + -RRB- stem cells is correlated with left_ventricular_ejection_fraction and plasma NT-proBNP levels in patients with acute_myocardial_infarction .
16467205	0	CXCR4	58,63	CD34	100,104	CXCR4	CD34	7852	947	Gene	Gene	receptors|nummod|START_ENTITY receptors|nmod|cells cells|compound|END_ENTITY	Integrin inhibition through Lyn-dependent cross talk from CXCR4 chemokine receptors in normal human CD34 + marrow cells .
17023512	0	CXCR4	18,23	CD34	70,74	CXCR4	CD34	7852	947	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|gene gene|nmod|cells cells|compound|END_ENTITY	Identification of CXCR4 as a new nitric_oxide-regulated gene in human CD34 + cells .
17350297	0	CXCR4	18,23	CD34	49,53	CXCR4	CD34	7852	947	Gene	Gene	expression|nmod|START_ENTITY down-regulated|nsubjpass|expression down-regulated|nmod|cells cells|nummod|END_ENTITY	The expression of CXCR4 is down-regulated on the CD34 + cells of patients with myelofibrosis_with_myeloid_metaplasia .
17533053	0	CXCR4	47,52	CD34	62,66	CXCR4	CD34	7852	947	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nmod|cells cells|compound|END_ENTITY	Fucoidan ingestion increases the expression of CXCR4 on human CD34 + cells .
17765649	0	CXCR4	158,163	CD34	22,26	CXCR4	CD34	7852	947	Gene	Gene	modulation|nmod|START_ENTITY related|nmod|modulation expression|dep|related consumption|nmod|expression stem|nmod|consumption stem|nsubj|Mobilization Mobilization|nmod|+ +|compound|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
18511598	0	CXCR4	20,25	CD34	38,42	CXCR4	CD34	7852	947	Gene	Gene	promoter|nummod|START_ENTITY promoter|nmod|END_ENTITY	Hypermethylation of CXCR4 promoter in CD34 + cells from patients with primary myelofibrosis .
18628138	0	CXCR4	84,89	CD34	33,37	CXCR4	CD34	7852	947	Gene	Gene	Antagonist|compound|START_ENTITY AMD3100|appos|Antagonist Cells|nmod|AMD3100 Cells|nsubj|Leukocytosis Leukocytosis|nmod|Progenitor Progenitor|compound|END_ENTITY	Leukocytosis and Mobilization of CD34 + Hematopoietic Progenitor Cells by AMD3100 , a CXCR4 Antagonist .
19113880	0	CXCR4	120,125	CD34	51,55	CXCR4	CD34	12767(Tax:10090)	12490(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|nmod|expression enhances|nsubj|culture culture|nmod|cells cells|compound|END_ENTITY	Short-term culture of umbilical cord blood-derived CD34 cells enhances engraftment into NOD/SCID mice through increased CXCR4 expression .
19208649	0	CXCR4	60,65	CD34	55,59	CXCR4	CD34	7852	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Intracoronary infusion of bone marrow-derived selected CD34 + CXCR4 + cells and non-selected mononuclear cells in patients with acute STEMI and reduced left_ventricular_ejection_fraction : results of randomized , multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial_Infarction -LRB- REGENT -RRB- Trial .
19463855	0	CXCR4	19,24	CD34	51,55	CXCR4	CD34	7852	947	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|SDF-KDEL SDF-KDEL|nmod|hematopoietic hematopoietic|compound|END_ENTITY	Down-regulation of CXCR4 expression by SDF-KDEL in CD34 -LRB- + -RRB- hematopoietic stem cells : An anti-human immunodeficiency virus strategy .
20957366	0	CXCR4	0,5	CD34	50,54	CXCR4	CD34	7852	947	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CXCR4 expression on transplanted peripheral blood CD34 + cells : relationship to engraftment after autologous transplantation in a cohort of multiple myeloma patients .
23060089	0	CXCR4	0,5	CD34	20,24	CXCR4	CD34	7852	947	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	CXCR4 expression in CD34 + cells and unit predominance after double umbilical cord blood transplantation .
24673458	0	CXCR4	4,9	CD34	46,50	CXCR4	CD34	7852	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	The CXCR4 and adhesion molecule expression of CD34 + hematopoietic cells mobilized by `` on-demand '' addition of plerixafor to granulocyte-colony-stimulating_factor .
26209038	0	CXCR4	92,97	CD34	85,89	CXCR4	CD34	7852	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , increases the number of circulating CD34 -LRB- + -RRB- CXCR4 -LRB- + -RRB- cells in patients with type 2 diabetes .
26209038	0	CXCR4	92,97	CD34	85,89	CXCR4	CD34	7852	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Sitagliptin , a dipeptidyl_peptidase-4 inhibitor , increases the number of circulating CD34 -LRB- + -RRB- CXCR4 -LRB- + -RRB- cells in patients with type 2 diabetes .
26436997	0	CXCR4	62,67	CD34	41,45	CXCR4	CD34	7852	947	Gene	Gene	+|compound|START_ENTITY exit|dep|+ exit|nmod|DNAM-1 DNAM-1|compound|END_ENTITY	'Em ergency exit ' of bone-marrow-resident CD34 -LRB- + -RRB- DNAM-1 -LRB- bright -RRB- CXCR4 -LRB- + -RRB- - committed lymphoid precursors during chronic infection and inflammation .
10229873	0	CXCR4	69,74	CD4	33,36	CXCR4	CD4	7852	920	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|chemotaxis chemotaxis|compound|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10628813	0	CXCR4	28,33	CD4	48,51	CXCR4	CD4	7852	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Influenza virus upregulates CXCR4 expression in CD4 + cells .
10823791	0	CXCR4	81,86	CD4	99,102	CXCR4	CD4	7852	920	Gene	Gene	coreceptors|dobj|START_ENTITY coreceptors|nmod|cells cells|nummod|END_ENTITY	Thalidomide suppresses Up-regulation of human_immunodeficiency_virus coreceptors CXCR4 and CCR5 on CD4 + T cells in humans .
10864648	0	CXCR4	130,135	CD4	125,128	CXCR4	CD4	7852	920	Gene	Gene	CCR5|appos|START_ENTITY CCR5|compound|END_ENTITY	Glycosphingolipids promote entry of a broad range of human_immunodeficiency_virus_type_1 isolates into cell lines expressing CD4 , CXCR4 , and/or CCR5 .
10864687	0	CXCR4	48,53	CD4	33,36	CXCR4	CD4	7852	920	Gene	Gene	START_ENTITY|nsubj|infection infection|nmod|END_ENTITY	CD4-independent infection of two CD4 -LRB- - -RRB- / CCR5 -LRB- - -RRB- / CXCR4 -LRB- + -RRB- pre-T-cell lines by human and simian immunodeficiency viruses .
10878344	0	CXCR4	58,63	CD4	78,81	IL-15	CD4	3600	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|memory memory|compound|END_ENTITY	Cytokines and cell surface molecules independently induce CXCR4 expression on CD4 + CCR7 + human memory T cells .
10967018	0	CXCR4	92,97	CD4	58,61	CXCR4	CD4	7852	920	Gene	Gene	CD45RO|appos|START_ENTITY END_ENTITY|appos|CD45RO	Adenoids provide a microenvironment for the generation of CD4 -LRB- + -RRB- , CD45RO -LRB- + -RRB- , L-selectin -LRB- - -RRB- , CXCR4 -LRB- + -RRB- , CCR5 -LRB- + -RRB- T lymphocytes , a lymphocyte phenotype found in the middle_ear_effusion .
11023494	0	CXCR4	33,38	CD4	51,54	CXCR4	CD4	7852	920	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|T T|compound|END_ENTITY	Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4 -LRB- + -RRB- T cells during human endotoxemia and after stimulation with -LRB- myco -RRB- bacterial antigens : the role of cytokines .
11181132	0	CXCR4	79,84	CD4	97,100	CXCR4	CD4	7852	920	Gene	Gene	expression|nmod|START_ENTITY increased|dobj|expression increased|nmod|END_ENTITY	Patients with active tuberculosis have increased expression of HIV coreceptors CXCR4 and CCR5 on CD4 -LRB- + -RRB- T cells .
11943153	0	CXCR4	66,71	CD4	57,60	CXCR4	CD4	7852	920	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of N-glycans and SDF-1alpha on the coassociation of CD4 with CXCR4 at the plasma membrane of monocytic cells and blood lymphocytes .
12193696	0	CXCR4	52,57	CD4	72,75	CXCR4	CD4	7852	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Follicular dendritic cell-mediated up-regulation of CXCR4 expression on CD4 T cells and HIV pathogenesis .
12803997	0	CXCR4	71,76	CD4	78,81	CXCR4	CD4	7852	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Early viral load and CD4 + T cell count , but not percentage of CCR5 + or CXCR4 + CD4 + T cells , are associated with R5-to-X4_HIV_type_1 virus evolution .
14622278	0	CXCR4	61,66	CD4	18,21	CXCR4	CD4	7852	920	Gene	Gene	selection|nummod|START_ENTITY Identification|nmod|selection Identification|nmod|antibodies antibodies|compound|END_ENTITY	Identification of CD4 and transferrin_receptor antibodies by CXCR4 antibody-guided Pathfinder selection .
14990729	0	CXCR4	81,86	CD4	34,37	CXCR4	CD4	7852	920	Gene	Gene	receptors|compound|START_ENTITY interacting|nmod|receptors targets|advcl|interacting targets|dobj|cells cells|nummod|END_ENTITY	Extracellular Nef protein targets CD4 + T cells for apoptosis by interacting with CXCR4 surface receptors .
15000561	0	CXCR4	40,45	CD4	49,52	CXCR4	CD4	7852	920	Gene	Gene	START_ENTITY|nmod|T-cells T-cells|compound|END_ENTITY	Increased expression of HIV co-receptor CXCR4 on CD4 + T-cells in patients with active visceral_leishmaniasis .
15178707	0	CXCR4	37,42	CD4	82,85	CXCR4	CD4	7852	920	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	Lysophosphatidylcholine up-regulates CXCR4 chemokine_receptor expression in human CD4 T cells .
16249699	0	CXCR4	63,68	CD4	50,53	CXCR4	CD4	7852	920	Gene	Gene	START_ENTITY|amod|R5_HIV-1 R5_HIV-1|nmod|HIV-1 HIV-1|nmod|END_ENTITY	Enhanced replication of R5_HIV-1 over X4 HIV-1 in CD4 -LRB- + -RRB- CCR5 -LRB- + -RRB- CXCR4 -LRB- + -RRB- T cells .
17853408	0	CXCR4	27,32	CD4	93,96	CXCR4	CD4	7852	920	Gene	Gene	expression|compound|START_ENTITY Up-regulation|nmod|expression Up-regulation|dep|pathway pathway|nmod|cells cells|compound|END_ENTITY	Up-regulation of leukocyte CXCR4 expression by sulfatide : an L-selectin-dependent pathway on CD4 + T cells .
19779716	0	CXCR4	15,20	CD4	0,3	CXCR4	CD4	7852	920	Gene	Gene	CD45RA|acl|START_ENTITY CD45RA|compound|END_ENTITY	CD4 -LRB- + -RRB- CD45RA -LRB- + -RRB- CXCR4 -LRB- + -RRB- lymphocytes are inversely associated with progression in stages I-III melanoma patients .
20038787	0	CXCR4	113,118	CD4	11,14	CXCR4	CD4	7852	920	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|lymphocytopenia lymphocytopenia|compound|END_ENTITY	Idiopathic CD4 + T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4 .
20051874	0	CXCR4	165,170	CD4	117,120	CXCR4	CD4	7852	920	Gene	Gene	levels|nmod|START_ENTITY expressing|dobj|levels expressing|advmod|efficiently efficiently|nmod|phenotype phenotype|nmod|cells cells|compound|END_ENTITY	Pairwise comparison_of_isogenic_HIV-1_viruses : R5 phenotype replicates more efficiently than X4 phenotype in primary CD4 + T cells expressing physiological levels of CXCR4 .
20300007	0	CXCR4	60,65	CD4	89,92	CXCR4	CD4	7852	920	Gene	Gene	START_ENTITY|nmod|T-cells T-cells|compound|END_ENTITY	The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4 -LRB- + -RRB- T-cells and monocytes and is superior to valproic_acid for latent HIV-1 expression in vitro .
20728351	0	CXCR4	79,84	CD4	0,3	CXCR4	CD4	7852	920	Gene	Gene	antagonist|compound|START_ENTITY targeting|nmod|antagonist mimics|xcomp|targeting mimics|nsubj|END_ENTITY	CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist .
20732363	0	CXCR4	107,112	CD4	125,128	CXCR4	CD4	7852	920	Gene	Gene	downregulation|nmod|START_ENTITY induces|dobj|downregulation induces|nmod|T-cells T-cells|compound|END_ENTITY	Monoclonal antibody-assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4 + T-cells .
20861743	0	CXCR4	27,32	CD4	5,8	CXCR4	CD4	7852	920	Gene	Gene	density|compound|START_ENTITY density|compound|T-cell T-cell|compound|END_ENTITY	High CD4 -LRB- + -RRB- T-cell surface CXCR4 density as a risk factor for R5 to X4 switch in the course of HIV-1_infection .
22532671	0	CXCR4	27,32	CD4	54,57	CXCR4	CD4	12767(Tax:10090)	12504(Tax:10090)	Gene	Gene	Single|nmod|START_ENTITY identifies|nsubj|Single identifies|dobj|cells cells|compound|END_ENTITY	Single and coexpression of CXCR4 and CXCR5 identifies CD4 T helper cells in distinct lymph node niches during influenza_virus_infection .
22568557	0	CXCR4	22,27	CD4	119,122	CXCR4	CD4	7852	920	Gene	Gene	expression|nummod|START_ENTITY regulation|nmod|expression contributes|nsubj|regulation contributes|nmod|cells cells|amod|CXCL12-dependent CXCL12-dependent|dep|migration migration|nmod|T T|compound|END_ENTITY	Altered regulation of CXCR4 expression during aging contributes to increased CXCL12-dependent chemotactic migration of CD4 -LRB- + -RRB- T cells .
9108384	0	CXCR4	134,139	CD4	45,48	CXCR4	CD4	7852	920	Gene	Gene	susceptible|nmod|START_ENTITY transfection|amod|susceptible transfection|amod|resistant resistant|dep|END_ENTITY	Human_immunodeficiency_virus -LRB- HIV -RRB- - resistant CD4 + UT-7 megakaryocytic human cell line becomes highly HIV-1_and_HIV-2 susceptible upon CXCR4 transfection : induction of cell differentiation by HIV-1_infection .
9770524	0	CXCR4	0,5	CD4	61,64	CXCR4	CD4	7852	920	Gene	Gene	mediate|nsubj|START_ENTITY mediate|xcomp|cells cells|nsubj|death death|nmod|T T|compound|END_ENTITY	CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4 -LRB- + -RRB- T cells .
9823770	0	CXCR4	38,43	CD4	64,67	CXCR4	CD4	7852	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4 + T lymphocytes and enhance HIV-1 replication .
9892690	0	CXCR4	0,5	CD4	43,46	CXCR4	CD4	7852	920	Gene	Gene	utilization|compound|START_ENTITY sufficient|nsubj|utilization sufficient|xcomp|trigger trigger|dobj|depletion depletion|compound|END_ENTITY	CXCR4 utilization is sufficient to trigger CD4 + T cell depletion in HIV-1-infected human lymphoid tissue .
19228923	0	CXCR4	50,55	CD49d	75,80	CXCR4	CD49d	7852	3676	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Mantle_cell_lymphoma cells express high levels of CXCR4 , CXCR5 , and VLA-4 -LRB- CD49d -RRB- : importance for interactions with the stromal microenvironment and specific targeting .
15549771	0	CXCR4	19,24	CD8	45,48	CXCR4	CD8	7852	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of CXCR4 expression on human CD8 + T cells during peripheral differentiation .
24973450	0	CXCR4	14,19	CD8	36,39	CXCR4	CD8	7852	925	Gene	Gene	self-renewal|nsubj|START_ENTITY self-renewal|amod|critical critical|nmod|self-renewal self-renewal|compound|END_ENTITY	Cutting edge : CXCR4 is critical for CD8 + memory T cell homeostatic self-renewal but not rechallenge self-renewal .
25714247	0	CXCR4	17,22	CD8	86,89	CXCR4	CD8	7852	925	Gene	Gene	Antagonists|nsubj|START_ENTITY Antagonists|xcomp|Expansion Expansion|nmod|Cells Cells|compound|END_ENTITY	HIV-1 Coreceptor CXCR4 Antagonists Promote Clonal Expansion of Viral Epitope-Specific CD8 + T Cells During Acute_SIV_Infection in Rhesus_Monkeys In Vivo .
17331556	0	CXCR4	41,46	CXCL-12	60,67	CXCR4	CXCL-12	7852	6387	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	The role of N-glycosylation sites on the CXCR4 receptor for CXCL-12 binding and signaling and X4_HIV-1_viral_infectivity .
12239139	0	CXCR4	153,158	CXCL12	33,39	CXCR4	CXCL12	7852	6387	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	CCR5-binding chemokines modulate CXCL12 -LRB- SDF-1 -RRB- - induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor .
12714578	0	CXCR4	114,119	CXCL12	30,36	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Stromal cell-derived factor-1 / CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G -LRB- alpha -RRB- i proteins and enhances engraftment of competitive , repopulating stem cells .
14684377	0	CXCR4	92,97	CXCL12	6,12	CXCR4	CXCL12	7852	6387	Gene	Gene	cells|nmod|START_ENTITY production|nmod|cells regulates|dobj|production regulates|nsubj|END_ENTITY	SDF-1 / CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 .
15358596	0	CXCR4	21,26	CXCL12	0,6	CXCR4	CXCL12	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity .
15479278	0	CXCR4	70,75	CXCL12	114,120	CXCR4	CXCL12	7852	6387	Gene	Gene	activation|nmod|START_ENTITY ligand|nsubj|activation ligand|dobj|factor-1alpha factor-1alpha|appos|END_ENTITY	T-helper 2 cytokines attenuate senescent eosinophil activation by the CXCR4 ligand stromal-derived factor-1alpha -LRB- CXCL12 -RRB- .
15536153	0	CXCR4	78,83	CXCL12	103,109	CXCR4	CXCL12	7852	6387	Gene	Gene	desensitization|compound|START_ENTITY desensitization|nmod|END_ENTITY	WHIM_syndromes with different_genetic_anomalies are accounted for by impaired CXCR4 desensitization to CXCL12 .
15618475	0	CXCR4	109,114	CXCL12	101,107	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|nummod|START_ENTITY SDF-1alpha|dep|axis SDF-1alpha|appos|END_ENTITY	Flt3_ligand and the Flt3 receptor regulate hematopoietic cell migration by modulating the SDF-1alpha -LRB- CXCL12 -RRB- / CXCR4 axis .
15647826	0	CXCR4	62,67	CXCL12	54,60	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY blocks|nsubj|axis localization|parataxis|blocks localization|nmod|SDF-1 SDF-1|appos|END_ENTITY	Skeletal localization and neutralization of the SDF-1 -LRB- CXCL12 -RRB- / CXCR4 axis blocks prostate_cancer metastasis and growth in osseous sites in vivo .
16267013	0	CXCR4	17,22	CXCL12	82,88	CXCR4	CXCL12	7852	6387	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|nmod|increases increases|appos|END_ENTITY	Up-regulation of CXCR4 expression in PC-3 cells by stromal-derived factor-1alpha -LRB- CXCL12 -RRB- increases endothelial adhesion and transendothelial migration : role of MEK/ERK signaling pathway-dependent NF-kappaB activation .
16397027	0	CXCR4	24,29	CXCL12	0,6	CXCR4	CXCL12	7852	6387	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ attract|dobj|cells attract|nsubj|END_ENTITY	CXCL12 does not attract CXCR4 + human metastatic_neuroblastoma cells : clinical implications .
16702540	0	CXCR4	131,136	CXCL12	20,26	CXCR4	CXCL12	7852	6387	Gene	Gene	induced|nmod|START_ENTITY neurons|acl|induced pattern|nmod|neurons modulates|dobj|pattern modulates|nsubj|END_ENTITY	The chemokine SDF-1 / CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4 .
16725153	0	CXCR4	17,22	CXCL12	101,107	CXCR4	CXCL12	7852	6387	Gene	Gene	Recognition|nmod|START_ENTITY sulfotyrosine|nsubj|Recognition sulfotyrosine|nmod|chemokine_stromal_cell-derived_factor-1alpha chemokine_stromal_cell-derived_factor-1alpha|appos|END_ENTITY	Recognition of a CXCR4 sulfotyrosine by the chemokine_stromal_cell-derived_factor-1alpha -LRB- SDF-1alpha / CXCL12 -RRB- .
16787495	0	CXCR4	154,159	CXCL12	136,142	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro .
16875673	0	CXCR4	112,117	CXCL12	31,37	CXCR4	CXCL12	7852	6387	Gene	Gene	different|nmod|START_ENTITY receptor|amod|different endothelial|nmod|receptor binds|xcomp|endothelial binds|nsubj|factor factor|appos|END_ENTITY	Stromal cell-derived factor 1 -LRB- CXCL12 -RRB- binds to endothelial cells and signals through a receptor different from CXCR4 .
17056593	0	CXCR4	83,88	CXCL12	10,16	CXCR4	CXCL12	7852	6387	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Chemokine CXCL12 induces binding of ferritin_heavy_chain to the chemokine_receptor CXCR4 , alters CXCR4 signaling , and induces phosphorylation and nuclear translocation of ferritin_heavy_chain .
17165132	0	CXCR4	35,40	CXCL12	20,26	CXCR4	CXCL12	7852	6387	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|END_ENTITY	The pivotal role of CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis in bone metastasis .
17468394	0	CXCR4	140,145	CXCL12	100,106	CXCR4	CXCL12	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY decrease|nmod|receptors reduces|nmod|decrease reduces|dobj|END_ENTITY	Progesterone reduces the migration of mast cells toward the chemokine stromal cell-derived factor-1 / CXCL12 with an accompanying decrease in CXCR4 receptors .
18436740	0	CXCR4	0,5	CXCL12	95,101	CXCR4	CXCL12	7852	6387	Gene	Gene	dimerization|nummod|START_ENTITY account|nsubj|dimerization account|nmod|END_ENTITY	CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM_syndrome .
18753332	0	CXCR4	25,30	CXCL12	48,54	CXCR4	CXCL12	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|gene gene|compound|END_ENTITY	Functional expression of CXCR4 in somatotrophs : CXCL12 activates GH gene , GH production and secretion , and cellular proliferation .
18799424	0	CXCR4	20,25	CXCL12	75,81	CXCR4	CXCL12	7852	6387	Gene	Gene	basis|nmod|START_ENTITY sulfotyrosine|nsubj|basis sulfotyrosine|nmod|END_ENTITY	Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1 / CXCL12 .
18954561	0	CXCR4	31,36	CXCL12	63,69	CXCR4	CXCL12	7852	6387	Gene	Gene	receptor|appos|START_ENTITY Roles|nmod|receptor ligand|nsubj|Roles ligand|dobj|12 12|appos|END_ENTITY	Roles of chemokine receptor 4 -LRB- CXCR4 -RRB- and chemokine ligand 12 -LRB- CXCL12 -RRB- in metastasis of hepatocellular_carcinoma cells .
19109200	0	CXCR4	48,53	CXCL12	18,24	CXCR4	CXCL12	7852	6387	Gene	Gene	binding|nsubj|START_ENTITY reduces|xcomp|binding reduces|nsubj|Citrullination Citrullination|nmod|END_ENTITY	Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory_and_anti-HIV-1_activity_via_CXCR4 .
19443644	0	CXCR4	19,24	CXCL12	4,10	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|nummod|START_ENTITY END_ENTITY|dep|axis	The CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis is essential for the development of renal vasculature .
19594447	0	CXCR4	61,66	CXCL12	15,21	CXCR4	CXCL12	7852	6387	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7 .
20459090	0	CXCR4	65,70	CXCL12	16,22	CXCR4	CXCL12	7852	6387	Gene	Gene	activation|nmod|START_ENTITY prevents|dobj|activation END_ENTITY|acl:relcl|prevents	Targeting SDF-1 / CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design .
20484021	0	CXCR4	15,20	CXCL12	0,6	CXCR4	CXCL12	7852	6387	Gene	Gene	pathway|nummod|START_ENTITY /|dobj|pathway /|nsubj|END_ENTITY	CXCL12 -LRB- SDF-1 -RRB- / CXCR4 pathway in cancer .
20534452	0	CXCR4	81,86	CXCL12	56,62	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple_sclerosis .
21215244	0	CXCR4	36,41	CXCL12	21,27	CXCR4	CXCL12	7852	6387	Gene	Gene	signaling|nsubj|START_ENTITY Dysfunctions|parataxis|signaling Dysfunctions|nmod|END_ENTITY	-LSB- Dysfunctions of the CXCL12 -LRB- SDF-1 -RRB- / CXCR4 signaling axis in the WHIM_syndrome and the idiopathic CD4 -LRB- + -RRB- T-cell lymphocytopenia -RSB- .
21332278	0	CXCR4	35,40	CXCL12	42,48	CXCR4	CXCL12	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	Spatiotemporal|appos|START_ENTITY END_ENTITY|nsubj|Spatiotemporal	Spatiotemporal CCR1 , CCL3 -LRB- MIP-1a -RRB- , CXCR4 , CXCL12 -LRB- SDF-1a -RRB- expression patterns in a rat spinal_cord_injury model of posttraumatic neuropathic_pain .
21695171	0	CXCR4	64,69	CXCL12	36,42	CXCR4	CXCL12	7852	6387	Gene	Gene	receptors|appos|START_ENTITY receptors|nummod|END_ENTITY	Differential estrogen-regulation of CXCL12 chemokine receptors , CXCR4 and CXCR7 , contributes to the growth effect of estrogens in breast_cancer cells .
21878648	0	CXCR4	22,27	CXCL12	10,16	CXCR4	CXCL12	7852	6387	Gene	Gene	formed|nsubj|START_ENTITY uses|ccomp|formed uses|nsubj|END_ENTITY	Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt , extracellular_signal-regulated_kinase _ -LRB- ERK -RRB- 1/2 , and mammalian target of rapamycin complex 1 -LRB- mTORC1 -RRB- proteins to control chemotaxis and survival simultaneously in mature dendritic cells .
22114110	0	CXCR4	46,51	CXCL12	30,36	CXCR4	CXCL12	7852	6387	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Trophoblast-derived chemokine CXCL12 promotes CXCR4 expression and invasion of human first-trimester decidual stromal cells .
22472349	0	CXCR4	32,37	CXCL12	10,16	CXCR4	CXCL12	7852	6387	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic_cancer cells .
23133664	0	CXCR4	19,24	CXCL12	104,110	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	migration|nsubj|START_ENTITY migration|nmod|END_ENTITY	Dasatinib inhibits CXCR4 signaling in chronic_lymphocytic_leukaemia cells and impairs migration towards CXCL12 .
23289420	0	CXCR4	0,5	CXCL12	58,64	CXCR4	CXCL12	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	form|nsubj|START_ENTITY form|dobj|unit unit|nmod|END_ENTITY	CXCR4 and CXCR7 form a functional receptor unit for SDF-1 / CXCL12 in primary rodent microglia .
23333329	0	CXCR4	68,73	CXCL12	39,45	CXCR4	CXCL12	7852	6387	Gene	Gene	down-regulation|nmod|START_ENTITY inhibit|nmod|down-regulation inhibit|dobj|function function|nmod|END_ENTITY	CXCR7 agonists inhibit the function of CXCL12 by down-regulation of CXCR4 .
24292718	0	CXCR4	61,66	CXCL12	31,37	CXCR4	CXCL12	7852	6387	Gene	Gene	sing|nsubj|START_ENTITY peculiarities|parataxis|sing peculiarities|nmod|system system|compound|END_ENTITY	The peculiarities of the SDF-1 / CXCL12 system : in some cells , CXCR4 and CXCR7 sing solos , in others , they sing duets .
24480462	0	CXCR4	49,54	CXCL12	83,89	CXCR4	CXCL12	7852	6387	Gene	Gene	loops|compound|START_ENTITY derived|nmod|loops derived|nmod|END_ENTITY	Neutralising properties of peptides derived from CXCR4 extracellular loops towards CXCL12 binding and HIV-1_infection .
24497931	0	CXCR4	74,79	CXCL12	92,98	CXCR4	CXCL12	7852	6387	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	CXCR7 is highly expressed in acute_lymphoblastic_leukemia and potentiates CXCR4 response to CXCL12 .
24660779	0	CXCR4	77,82	CXCL12	50,56	CXCR4	CXCL12	7852	6387	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|acl|binding	Elucidating a key component of cancer metastasis : CXCL12 -LRB- SDF-1a -RRB- binding to CXCR4 .
24722947	0	CXCR4	50,55	CXCL12	25,31	CXCR4	CXCL12	7852	6387	Gene	Gene	START_ENTITY|nsubj|CXC_chemokine_ligand_12 CXC_chemokine_ligand_12|appos|END_ENTITY	CXC_chemokine_ligand_12 -LRB- CXCL12 -RRB- and its receptor CXCR4 .
24870556	0	CXCR4	61,66	CXCL12	98,104	CXCR4	CXCL12	7852	6387	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Breast_cancer metastasis : demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12 .
24904289	0	CXCR4	21,26	CXCL12	0,6	CXCR4	CXCL12	7852	6387	Gene	Gene	activity|compound|START_ENTITY modulation|nmod|activity modulation|nummod|END_ENTITY	CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment .
25305322	0	CXCR4	51,56	CXCL12	115,121	CXCR4	CXCL12	7852	6387	Gene	Gene	Migration|compound|START_ENTITY Triggers|dobj|Migration Triggers|nmod|END_ENTITY	Synaptic Release of CCL5 Storage Vesicles Triggers CXCR4 Surface Expression Promoting CTL Migration in Response to CXCL12 .
25833331	0	CXCR4	74,79	CXCL12	52,58	CXCR4	CXCL12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	Migration|nmod|START_ENTITY Migration|nmod|Independent Independent|compound|END_ENTITY	CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4 .
26813575	0	CXCR4	34,39	CXCL12	98,104	CXCR4	CXCL12	7852	6387	Gene	Gene	Interaction|nmod|START_ENTITY ligand|nsubj|Interaction ligand|dobj|END_ENTITY	Interaction of chemokine receptor CXCR4 in monomeric and dimeric state with its endogenous ligand CXCL12 : Coarse-grained simulations identify differences .
26818832	0	CXCR4	18,23	CXCL12	37,43	CXCR4	CXCL12	7852	6387	Gene	Gene	SDF-1|compound|START_ENTITY Expression|nmod|SDF-1 Expression|parataxis|important important|nsubj|END_ENTITY	Expression of the CXCR4 ligand SDF-1 / CXCL12 is prognostically important for adenocarcinoma and large_cell_carcinoma_of_the_lung .
25451233	0	CXCR4	33,38	CXCL14	0,6	CXCR4	CXCL14	7852	9547	Gene	Gene	modulator|nmod|START_ENTITY modulator|nsubj|END_ENTITY	CXCL14 is no direct modulator of CXCR4 .
19380869	0	CXCR4	27,32	CXCR7	0,5	CXCR4	CXCR7	7852	57007	Gene	Gene	heterodimerizes|nmod|START_ENTITY heterodimerizes|nsubj|END_ENTITY	CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling .
26042340	0	CXCR4	87,92	CXC_Chemokine_Receptor_7	21,45	CXCR4	CXC Chemokine Receptor 7	7852	57007	Gene	Gene	Antagonists|compound|START_ENTITY Switch|nmod|Antagonists Development|dep|Switch Development|nmod|Ligands Ligands|compound|END_ENTITY	Development of Novel CXC_Chemokine_Receptor_7 -LRB- CXCR7 -RRB- Ligands : Selectivity Switch from CXCR4 Antagonists with a Cyclic_Pentapeptide Scaffold .
22880115	0	CXCR4	43,48	CXC_chemokine_receptor_7	0,24	CXCR4	CXC chemokine receptor 7	12767(Tax:10090)	12778(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CXC_chemokine_receptor_7 -LRB- CXCR7 -RRB- regulates CXCR4 protein expression and capillary tuft development in mouse kidney .
15805285	0	CXCR4	91,96	Carboxyl-terminal_Src_kinase_homologous_kinase	0,46	CXCR4	Carboxyl-terminal Src kinase homologous kinase	7852	4145	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Carboxyl-terminal_Src_kinase_homologous_kinase negatively regulates the chemokine receptor CXCR4 through YY1 and impairs CXCR4/CXCL12 -LRB- SDF-1alpha -RRB- - mediated breast_cancer cell migration .
25149650	0	CXCR4	43,48	Chemokine_Receptor_4	22,42	CXCR4	Chemokine Receptor 4	12767(Tax:10090)	12767(Tax:10090)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Anticancer Effects of Chemokine_Receptor_4 -LRB- CXCR4 -RRB- Gene Silenced by CXCR4-siRNA in Nude_Mice Model of Ovarian_Cancer .
15837989	0	CXCR4	19,24	Chemokine_receptor	0,18	CXCR4	Chemokine receptor	7852	7852	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Chemokine_receptor CXCR4 expression in colorectal_cancer patients increases the risk for recurrence and for poor survival .
20813109	0	CXCR4	18,23	Clusterin	0,9	CXCR4	Clusterin	7852	1191	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Clusterin induces CXCR4 expression and migration of cardiac progenitor cells .
20076856	0	CXCR4	14,19	ERB	52,55	CXCR4	ERB	7852	2100	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CXCR4 , VLA-1 , LFA-3 and transducer of ERB in G-CSF-mobilised progenitor cells in acute myocardial_infarction .
20563261	0	CXCR4	28,33	ERG	42,45	CXCR4	ERG	7852	2078	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate_Cancer Cells .
23308188	0	CXCR4	104,109	ERK	75,78	CXCR4	ERK	12767(Tax:10090)	26413(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	RasGRP1 , but not RasGRP3 , is required for efficient thymic b-selection and ERK activation downstream of CXCR4 .
23723373	0	CXCR4	102,107	ERK1/2	73,79	CXCR4	ERK1/2	12767(Tax:10090)	26417;26413	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Toll-like_receptor_2-blocking antibodies promote angiogenesis and induce ERK1/2 and AKT signaling via CXCR4 in endothelial cells .
24870556	0	CXCR4	61,66	FOXP3	45,50	CXCR4	FOXP3	7852	50943	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Breast_cancer metastasis : demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12 .
18279715	0	CXCR4	0,5	Fanca	55,60	CXCR4	Fanca	12767(Tax:10090)	14087(Tax:10090)	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|END_ENTITY	CXCR4 induction in hematopoietic progenitor cells from Fanca -LRB- - / - -RRB- , - c -LRB- - / - -RRB- , and - d2 -LRB- - / - -RRB- mice .
25145299	0	CXCR4	0,5	GSK3b	15,20	CXCR4	GSK3b	7852	2932	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	CXCR4 promotes GSK3b expression in pancreatic_cancer cells via the Akt pathway .
24511119	0	CXCR4	23,28	Galectin-1	0,10	CXCR4	Galectin-1	7852	3956	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Galectin-1 upregulates CXCR4 to promote tumor progression and poor outcome in kidney_cancer .
17596540	0	CXCR4	71,76	Gfi-1	21,26	CXCR4	Gfi-1	7852	2672	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells .
18807177	0	CXCR4	54,59	HER2	75,79	CXCR4	HER2	7852	2064	Gene	Gene	START_ENTITY|nmod|overexpressing overexpressing|nummod|END_ENTITY	Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER2 overexpressing , estrogen_receptor-positive breast_cancer cells .
21925125	0	CXCR4	40,45	HER2	0,4	CXCR4	HER2	7852	2064	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric_cancer cells .
16840440	0	CXCR4	12,17	HGF	0,3	CXCR4	HGF	7852	3082	Gene	Gene	invasion|compound|START_ENTITY induces|dobj|invasion induces|nsubj|END_ENTITY	HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB .
20157762	0	CXCR4	16,21	HGF	0,3	CXCR4	HGF	7852	3082	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	HGF upregulates CXCR4 expression in gliomas via NF-kappaB : implications for glioma cell migration .
20869949	0	CXCR4	33,38	HIF-1a	74,80	CXCR4	HIF-1a	7852	3091	Gene	Gene	START_ENTITY|advcl|activating activating|dobj|END_ENTITY	Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1a in MSCs .
24618817	0	CXCR4	39,44	HIF-1a	60,66	CXCR4	HIF-1a	7852	3091	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|activation activation|compound|END_ENTITY	Hypoxia promotes migration and induces CXCR4 expression via HIF-1a activation in human osteosarcoma .
15837745	0	CXCR4	14,19	IFN-gamma	47,56	CXCR4	IFN-gamma	7852	3458	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck_squamous_cell_carcinoma .
9574513	0	CXCR4	51,56	IL-4	0,4	CXCR4	IL-4	7852	3565	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-4 induces functional cell-surface expression of CXCR4 on human T cells .
18310089	0	CXCR4	47,52	IL-6	30,34	CXCR4	IL-6	7852	3569	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Bone-derived SDF-1 stimulates IL-6 release via CXCR4 , ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral_cancer cells .
21312239	0	CXCR4	30,35	IL-6	45,49	CXCR4	IL-6	7852	3569	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	Stromal cell-derived factor-1 / CXCR4 promotes IL-6 production in human synovial fibroblasts .
20603605	0	CXCR4	20,25	ITF2	0,4	CXCR4	ITF2	7852	6925	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	ITF2 is a target of CXCR4 in MDA-MB-231_breast_cancer cells and is associated with reduced survival in estrogen receptor-negative breast_cancer .
20023696	0	CXCR4	102,107	K13	87,90	CXCR4	K13	7852	3860	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus-encoded viral FLICE inhibitory protein -LRB- vFLIP -RRB- K13 suppresses CXCR4 expression by upregulating miR-146a .
11756152	0	CXCR4	50,55	L540	116,120	CXCR4	IL-4	7852	3565	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 .
24760155	0	CXCR4	53,58	MIF	0,3	CXCR4	MIF	12767(Tax:10090)	17319(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling .
24318902	0	CXCR4	16,21	MiR-139	0,7	CXCR4	MiR-139	7852	406931	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MiR-139 targets CXCR4 and inhibits the proliferation and metastasis of laryngeal_squamous_carcinoma cells .
25514788	0	CXCR4	51,56	NFAT3	15,20	CXCR4	NFAT3	7852	4776	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Novel Role for NFAT3 in ERK-Mediated Regulation of CXCR4 .
22753736	0	CXCR4	62,67	Nef	16,19	CXCR4	Nef	7852	6285	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	SIVmac - Nef down-regulates cell surface expression of CXCR4 in tumor cells and inhibits proliferation , migration and angiogenesis .
20484220	0	CXCR4	16,21	PDGFRbeta	25,34	CXCR4	PDGFRbeta	12767(Tax:10090)	18596(Tax:10090)	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|dep|END_ENTITY	Contribution of CXCR4 -LRB- + -RRB- / PDGFRbeta -LRB- + -RRB- progenitor cells in hypoxic_alveolar_arterioles muscularization : role of myocardin .
21245057	0	CXCR4	79,84	Parathyroid_hormone	0,19	CXCR4	Parathyroid hormone	12767(Tax:10090)	19226(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Parathyroid_hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4 -LRB- + -RRB- stem cells into the ischaemic heart .
18155192	0	CXCR4	73,78	Plectin	0,7	CXCR4	Plectin	7852	5339	Gene	Gene	signaling|nmod|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1_infection .
22345572	0	CXCR4	0,5	Rac1_and_matrix_metalloproteinase-2	82,117	CXCR4	Rac1 and matrix metalloproteinase-2	60628(Tax:10116)	363875;81686	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1_and_matrix_metalloproteinase-2 .
21211783	0	CXCR4	22,27	Robo4	0,5	CXCR4	Robo4	7852	54538	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches .
10556181	0	CXCR4	45,50	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	levels|nummod|START_ENTITY correlate|nmod|levels correlate|nsubj|responsiveness responsiveness|compound|END_ENTITY	SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells .
10602415	0	CXCR4	41,46	SDF-1	169,174	CXCR4	SDF-1	7852	6387	Gene	Gene	Overexpression|nmod|START_ENTITY associated|nsubjpass|Overexpression associated|nmod|response response|nmod|stromal_cell-derived_factor-1 stromal_cell-derived_factor-1|appos|END_ENTITY	Overexpression of the chemokine receptor CXCR4 in B_cell_chronic_lymphocytic_leukemia is associated with increased functional response to stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
11458529	1	CXCR4	113,118	SDF-1	107,112	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	interactions|nummod|START_ENTITY /|dobj|interactions /|nsubj|role role|nmod|END_ENTITY	The role of SDF-1 / CXCR4 interactions .
11867624	0	CXCR4	78,83	SDF-1	138,143	CXCR4	SDF-1	7852	6387	Gene	Gene	binding|compound|START_ENTITY factor-1|dep|binding regulates|dobj|factor-1 regulates|nmod|processing processing|nmod|END_ENTITY	Leukocyte_elastase negatively regulates Stromal cell-derived factor-1 -LRB- SDF-1 -RRB- / CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4 .
11867624	0	CXCR4	78,83	SDF-1	71,76	CXCR4	SDF-1	7852	6387	Gene	Gene	binding|compound|START_ENTITY factor-1|dep|binding factor-1|appos|END_ENTITY	Leukocyte_elastase negatively regulates Stromal cell-derived factor-1 -LRB- SDF-1 -RRB- / CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4 .
11985470	0	CXCR4	121,126	SDF-1	29,34	CXCR4	SDF-1	7852	6387	Gene	Gene	receptor|compound|START_ENTITY affinity|nmod|receptor increases|dobj|affinity increases|nsubj|cyclization cyclization|nmod|analogue analogue|compound|END_ENTITY	C-terminal cyclization of an SDF-1 small peptide analogue dramatically increases receptor affinity and activation of the CXCR4 receptor .
12004084	0	CXCR4	23,28	SDF-1	136,141	CXCR4	SDF-1	7852	6387	Gene	Gene	cells|compound|START_ENTITY have|nsubj|cells have|nmod|response response|nmod|END_ENTITY	Immature leukemic CD34 + CXCR4 + cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1 .
12122049	0	CXCR4	26,31	SDF-1	106,111	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	system|nummod|START_ENTITY system|dep|regulation regulation|nmod|plasticity plasticity|compound|END_ENTITY	A dual role for the SDF-1 / CXCR4 chemokine receptor system in adult brain : isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia .
12122049	0	CXCR4	26,31	SDF-1	20,25	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	system|nummod|START_ENTITY role|dep|system role|nmod|END_ENTITY	A dual role for the SDF-1 / CXCR4 chemokine receptor system in adult brain : isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia .
12239139	0	CXCR4	153,158	SDF-1	41,46	CXCR4	SDF-1	7852	6387	Gene	Gene	receptor|compound|START_ENTITY CXCL12|nmod|receptor CXCL12|appos|END_ENTITY	CCR5-binding chemokines modulate CXCL12 -LRB- SDF-1 -RRB- - induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor .
12761880	0	CXCR4	14,19	SDF-1	32,37	CXCR4	SDF-1	7852	6387	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CXCR4 and CXCL12 -LRB- SDF-1 -RRB- in human prostate_cancers -LRB- PCa -RRB- in vivo .
14555820	0	CXCR4	69,74	SDF-1	45,50	CXCR4	SDF-1	7852	6387	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- and expression of CXCR4 in human bone marrow endothelial cells .
14684377	0	CXCR4	92,97	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	cells|nmod|START_ENTITY production|nmod|cells regulates|dobj|production END_ENTITY|appos|regulates	SDF-1 / CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 .
14688392	0	CXCR4	45,50	SDF-1	39,44	CXCR4	SDF-1	7852	6387	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Mobilization of myeloma cells involves SDF-1 / CXCR4 signaling and downregulation of VLA-4 .
15033938	0	CXCR4	13,18	SDF-1	156,161	CXCR4	SDF-1	7852	6387	Gene	Gene	complex|compound|START_ENTITY binds|nsubj|complex binds|dobj|CXC CXC|appos|END_ENTITY	A syndecan-4 / CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC chemokine stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
15078139	0	CXCR4	77,82	SDF-1	71,76	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nsubj|START_ENTITY Chemokines|parataxis|axis Chemokines|dep|role role|nmod|END_ENTITY	Chemokines and their receptors as therapeutic targets : the role of the SDF-1 / CXCR4 axis .
15328152	0	CXCR4	17,22	SDF-1	126,131	CXCR4	SDF-1	7852	6387	Gene	Gene	Incorporation|nmod|START_ENTITY primes|nsubj|Incorporation primes|nmod|gradient gradient|compound|END_ENTITY	Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient .
15542441	0	CXCR4	38,43	SDF-1	31,36	CXCR4	SDF-1	7852	6387	Gene	Gene	couple|compound|START_ENTITY plays|nsubj|couple \|ccomp|plays \|nsubj|Stromal_cell-derived_factor-1 Stromal_cell-derived_factor-1|appos|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- \ CXCR4 couple plays multiple roles on haematopoietic progenitors at the border between the old cytokine and new chemokine worlds : survival , cell cycling and trafficking .
15647826	0	CXCR4	62,67	SDF-1	48,53	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY blocks|nsubj|axis localization|parataxis|blocks localization|nmod|END_ENTITY	Skeletal localization and neutralization of the SDF-1 -LRB- CXCL12 -RRB- / CXCR4 axis blocks prostate_cancer metastasis and growth in osseous sites in vivo .
15805265	0	CXCR4	66,71	SDF-1	21,26	CXCR4	SDF-1	7852	6387	Gene	Gene	signaling|compound|START_ENTITY alteration|nmod|signaling response|nmod|alteration response|compound|END_ENTITY	p210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression .
16005185	0	CXCR4	45,50	SDF-1	39,44	CXCR4	SDF-1	7852	6387	Gene	Gene	START_ENTITY|dep|signaling signaling|nmod|END_ENTITY	Diverse signaling pathways through the SDF-1 / CXCR4 chemokine axis in prostate_cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis .
16262623	0	CXCR4	10,15	SDF-1	4,9	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	pathway|nummod|START_ENTITY END_ENTITY|dep|pathway	The SDF-1 / CXCR4 pathway and the development of the cerebellar system .
16597663	0	CXCR4	39,44	SDF-1	16,21	CXCR4	SDF-1	7852	6387	Gene	Gene	START_ENTITY|nsubj|Localisation Localisation|nmod|END_ENTITY	Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age_related_macular_degeneration .
16648859	0	CXCR4	87,92	SDF-1	32,37	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	+|compound|START_ENTITY hemangiocytes|nummod|+ recruitment|nmod|hemangiocytes induces|nmod|recruitment induces|nsubj|deployment deployment|nmod|END_ENTITY	Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4 + hemangiocytes .
16702540	0	CXCR4	131,136	SDF-1	14,19	CXCR4	SDF-1	7852	6387	Gene	Gene	induced|nmod|START_ENTITY neurons|acl|induced pattern|nmod|neurons modulates|dobj|pattern END_ENTITY|parataxis|modulates	The chemokine SDF-1 / CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4 .
16863903	0	CXCR4	25,30	SDF-1	19,24	CXCR4	SDF-1	7852	6387	Gene	Gene	interactions|nummod|START_ENTITY stromal|nsubj|interactions Mutual|parataxis|stromal Mutual|amod|END_ENTITY	Mutual , reciprocal SDF-1 / CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice .
16974072	0	CXCR4	22,27	SDF-1	16,21	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	interaction|nsubj|START_ENTITY role|parataxis|interaction role|nmod|END_ENTITY	Crucial role of SDF-1 / CXCR4 interaction in the recruitment of transplanted dermal multipotent cells to sublethally irradiated bone marrow .
17046575	0	CXCR4	142,147	SDF-1	72,77	CXCR4	SDF-1	7852	6387	Gene	Gene	plays|nmod|START_ENTITY Cloning|parataxis|plays Cloning|dobj|stromal_cell-derived_factor-1 stromal_cell-derived_factor-1|appos|END_ENTITY	Cloning and characterizing mutated human stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- : C-terminal alpha-helix of SDF-1alpha plays a critical role in CXCR4 activation and signaling , but not in CXCR4 binding affinity .
17049119	0	CXCR4	115,120	SDF-1	109,114	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin_lymphoma by regulating SDF-1 / CXCR4 axis in vitro .
17096920	0	CXCR4	27,32	SDF-1	21,26	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY axis|dep|-LSB- -LSB-|nmod|END_ENTITY	-LSB- Research advance on SDF-1 / CXCR4 axis associated with hematological_malignancies : review -RSB- .
17165132	0	CXCR4	35,40	SDF-1	28,33	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|CXCL12 CXCL12|appos|END_ENTITY	The pivotal role of CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis in bone metastasis .
17379424	0	CXCR4	52,57	SDF-1	46,51	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|dep|axis	Beta-catenin is a promising key factor in the SDF-1 / CXCR4 axis on metastasis of pancreatic_cancer .
17463394	0	CXCR4	18,23	SDF-1	12,17	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|nummod|START_ENTITY Role|dep|axis Role|nmod|END_ENTITY	Role of the SDF-1 / CXCR4 axis in the pathogenesis of lung_injury and fibrosis .
17522382	0	CXCR4	10,15	SDF-1	4,9	CXCR4	SDF-1	7852	6387	Gene	Gene	pair|nummod|START_ENTITY contributor|nsubj|pair END_ENTITY|parataxis|contributor	The SDF-1 / CXCR4 ligand/receptor pair is an important contributor to several types of ocular_neovascularization .
17972109	0	CXCR4	20,25	SDF-1	14,19	CXCR4	SDF-1	7852	6387	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of SDF-1 / CXCR4 in injured human kidneys .
17976542	0	CXCR4	14,19	SDF-1	8,13	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	system|nummod|START_ENTITY marrow|nsubj|system Role|parataxis|marrow Role|nmod|END_ENTITY	Role of SDF-1 / CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral_infarct .
18206727	0	CXCR4	14,19	SDF-1	8,13	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Altered SDF-1 / CXCR4 axis in patients with primary_myelofibrosis and in the Gata1 low mouse model of the disease .
18310089	0	CXCR4	47,52	SDF-1	13,18	CXCR4	SDF-1	7852	6387	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Bone-derived SDF-1 stimulates IL-6 release via CXCR4 , ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral_cancer cells .
18426684	0	CXCR4	30,35	SDF-1	24,29	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY review|dep|axis review|compound|END_ENTITY	-LSB- Advance of research on SDF-1 / CXCR4 axis and angiogenesis in leukemia -- review -RSB- .
18448868	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	interaction|compound|START_ENTITY regulates|nsubj|interaction END_ENTITY|appos|regulates	SDF-1 / CXCR4 and VLA-4 interaction regulates homing in Waldenstrom_macroglobulinemia .
18799424	0	CXCR4	20,25	SDF-1	69,74	CXCR4	SDF-1	7852	6387	Gene	Gene	basis|nmod|START_ENTITY sulfotyrosine|nsubj|basis sulfotyrosine|nmod|CXCL12 CXCL12|compound|END_ENTITY	Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1 / CXCL12 .
18997494	0	CXCR4	27,32	SDF-1	21,26	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY stem|nsubj|axis role|parataxis|stem role|nmod|END_ENTITY	The critical role of SDF-1 / CXCR4 axis in cancer and cancer stem cells metastasis .
19002187	0	CXCR4	18,23	SDF-1	12,17	CXCR4	SDF-1	7852	6387	Gene	Gene	signalling|nsubj|START_ENTITY Blockade|parataxis|signalling Blockade|nmod|END_ENTITY	Blockade of SDF-1 / CXCR4 signalling inhibits pancreatic_cancer progression in vitro via inactivation of canonical Wnt pathway .
19379577	0	CXCR4	18,23	SDF-1	12,17	CXCR4	SDF-1	7852	6387	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of SDF-1 / CXCR4 on the chemotaxis of cord blood AC133 -LRB- + -RRB- cells -RSB- .
19379578	0	CXCR4	23,28	SDF-1	17,22	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY Contribution|dep|axis Contribution|nmod|END_ENTITY	-LSB- Contribution of SDF-1 / CXCR4 axis on proliferation of megakaryocyte co-cultured with human umbilical cord blood-derived stromal cells -RSB- .
19423843	0	CXCR4	24,29	SDF-1	18,23	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY attenuates|nsubj|axis Inhibition|parataxis|attenuates Inhibition|nmod|END_ENTITY	Inhibition of the SDF-1 / CXCR4 axis attenuates neonatal_hypoxia-induced pulmonary_hypertension .
19443644	0	CXCR4	19,24	SDF-1	12,17	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|nummod|START_ENTITY CXCL12|dep|axis CXCL12|appos|END_ENTITY	The CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis is essential for the development of renal vasculature .
19459330	0	CXCR4	39,44	SDF-1	128,133	CXCR4	SDF-1	7852	6387	Gene	Gene	expression|nummod|START_ENTITY modification|nmod|expression Effects|nmod|modification stem|nsubj|Effects stem|nmod|END_ENTITY	-LSB- Effects of Snail gene modification on CXCR4 expression of human bone mesenchymal stem cells and their capacity of migration to SDF-1 in vitro -RSB- .
19513623	0	CXCR4	18,23	SDF-1	12,17	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|END_ENTITY	The role of SDF-1 / CXCR4 axis in ovarian_cancer metastasis .
19588204	0	CXCR4	93,98	SDF-1	87,92	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Hepatic stellate cells promote liver metastasis of colon_cancer cells by the action of SDF-1 / CXCR4 axis .
19770040	0	CXCR4	18,23	SDF-1	12,17	CXCR4	SDF-1	100192360(Tax:8355)	399030(Tax:8355)	Gene	Gene	signaling|nsubj|START_ENTITY Analysis|parataxis|signaling Analysis|nmod|END_ENTITY	Analysis of SDF-1 / CXCR4 signaling in primordial germ cell migration and survival or differentiation in Xenopus_laevis .
19821487	0	CXCR4	0,5	SDF-1	80,85	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|xcomp|independent independent|nmod|END_ENTITY	CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1 .
19885584	0	CXCR4	0,5	SDF-1	57,62	CXCR4	SDF-1	7852	6387	Gene	Gene	localization|nummod|START_ENTITY follows|nsubj|localization follows|dobj|binding binding|nmod|END_ENTITY	CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal_cell_carcinoma .
20009035	0	CXCR4	84,89	SDF-1	78,83	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|nsubj|START_ENTITY promotes|parataxis|axis promotes|advcl|perturbing perturbing|dobj|END_ENTITY	Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1 : CXCR4 axis .
20118565	0	CXCR4	18,23	SDF-1	12,17	CXCR4	SDF-1	7852	6387	Gene	Gene	system|nummod|START_ENTITY Role|dep|system Role|nmod|END_ENTITY	Role of the SDF-1 / CXCR4 system in myocardial_infarction .
20151462	0	CXCR4	51,56	SDF-1	41,46	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY Induction|nmod|receptors Induction|nmod|END_ENTITY	Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors .
20153802	0	CXCR4	75,80	SDF-1	69,74	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY axis|dep|cleavage cleavage|ccomp|disrupt disrupt|dobj|END_ENTITY	Fifth complement cascade protein -LRB- C5 -RRB- cleavage fragments disrupt the SDF-1 / CXCR4 axis : further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells .
20181837	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|appos|contributes	SDF-1 / CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis .
20459090	0	CXCR4	65,70	SDF-1	10,15	CXCR4	SDF-1	7852	6387	Gene	Gene	activation|nmod|START_ENTITY prevents|dobj|activation CXCL12|acl:relcl|prevents CXCL12|dep|Targeting Targeting|dobj|END_ENTITY	Targeting SDF-1 / CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design .
20484021	0	CXCR4	15,20	SDF-1	8,13	CXCR4	SDF-1	7852	6387	Gene	Gene	pathway|nummod|START_ENTITY /|dobj|pathway /|nsubj|CXCL12 CXCL12|appos|END_ENTITY	CXCL12 -LRB- SDF-1 -RRB- / CXCR4 pathway in cancer .
20524780	0	CXCR4	58,63	SDF-1	52,57	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	The spleen recruits endothelial progenitor cell via SDF-1 / CXCR4 axis in mice .
20563655	0	CXCR4	71,76	SDF-1	40,45	CXCR4	SDF-1	7852	6387	Gene	Gene	stromal_derived_factor-1|appos|START_ENTITY stromal_derived_factor-1|appos|END_ENTITY	Expression of stromal_derived_factor-1 -LRB- SDF-1 -RRB- and chemokine_receptor -LRB- CXCR4 -RRB- in bone metastasis of renal_carcinoma .
20637871	0	CXCR4	28,33	SDF-1	22,27	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Can inhibition of the SDF-1 / CXCR4 axis eradicate acute_leukemia ?
20859707	0	CXCR4	19,24	SDF-1	13,18	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY roles|dep|axis roles|nmod|END_ENTITY	The roles of SDF-1 / CXCR4 axis and its relationship with apoptosis in the myelodysplastic_syndromes .
21215244	0	CXCR4	36,41	SDF-1	29,34	CXCR4	SDF-1	7852	6387	Gene	Gene	signaling|nsubj|START_ENTITY Dysfunctions|parataxis|signaling Dysfunctions|nmod|CXCL12 CXCL12|appos|END_ENTITY	-LSB- Dysfunctions of the CXCL12 -LRB- SDF-1 -RRB- / CXCR4 signaling axis in the WHIM_syndrome and the idiopathic CD4 -LRB- + -RRB- T-cell lymphocytopenia -RSB- .
21443090	0	CXCR4	100,105	SDF-1	94,99	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Adipose-derived stem cells promote gastric_cancer cell growth , migration and invasion through SDF-1 / CXCR4 axis .
21518481	0	CXCR4	16,21	SDF-1	10,15	CXCR4	SDF-1	7852	6387	Gene	Gene	Level|dep|START_ENTITY Level|nmod|END_ENTITY	-LSB- Level of SDF-1 / CXCR4 in children with acute_leukemia and its significance -RSB- .
21556934	0	CXCR4	33,38	SDF-1	27,32	CXCR4	SDF-1	7852	6387	Gene	Gene	behavior|dep|START_ENTITY behavior|nmod|END_ENTITY	The biological behavior of SDF-1 / CXCR4 in patients with myelodysplastic_syndrome .
21567300	0	CXCR4	74,79	SDF-1	31,36	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY induces|nsubj|activation _|ccomp|induces _|nsubj|_ _|appos|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / chemokine _ -LRB- C-X-C_motif -RRB- _ receptor_4 -LRB- CXCR4 -RRB- axis activation induces intra-islet glucagon-like_peptide-1 -LRB- GLP-1 -RRB- production and enhances beta cell survival .
21587260	0	CXCR4	16,21	SDF-1	10,15	CXCR4	SDF-1	7852	6387	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting SDF-1 / CXCR4 to inhibit tumour vasculature for treatment of glioblastomas .
21618098	0	CXCR4	54,59	SDF-1	48,53	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Pathways implicated in stem cell migration : the SDF-1 / CXCR4 axis .
21752744	0	CXCR4	102,107	SDF-1	96,101	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|nsubj|START_ENTITY therapy|parataxis|axis therapy|acl|acts acts|nmod|homing homing|nmod|END_ENTITY	Dual stem cell therapy after myocardial_infarction acts specifically by enhanced homing via the SDF-1 / CXCR4 axis .
21802140	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY END_ENTITY|dep|axis	SDF-1 / CXCR4 axis in myelodysplastic_syndromes : correlation with angiogenesis and apoptosis .
21821779	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|appos|mediates	SDF-1 / CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury .
21906874	0	CXCR4	76,81	SDF-1	70,75	CXCR4	SDF-1	7852	6387	Gene	Gene	CXCR7|dep|START_ENTITY CXCR7|compound|END_ENTITY	Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1 / CXCR4 and SDF-1 / CXCR7 signaling .
21909361	0	CXCR4	72,77	SDF-1	66,71	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY END_ENTITY|dep|axis	Osteopontin enhances the expression and activity of MMP-2 via the SDF-1 / CXCR4 axis in hepatocellular_carcinoma cell lines .
22058039	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY modulates|nsubj|axis END_ENTITY|appos|modulates	SDF-1 / CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis , migration and cytokine secretion .
22069486	0	CXCR4	97,102	SDF-1	91,96	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nsubj|START_ENTITY Identification|parataxis|axis Identification|nmod|niche niche|acl|harboring harboring|dobj|cells cells|nmod|END_ENTITY	Identification of hepatic niche harboring human acute_lymphoblastic_leukemic cells via the SDF-1 / CXCR4 axis .
22092795	0	CXCR4	55,60	SDF-1	31,36	CXCR4	SDF-1	7852	6387	Gene	Gene	START_ENTITY|nsubj|Stromal_cell-derived_factor_1 Stromal_cell-derived_factor_1|appos|END_ENTITY	Stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- and its receptor CXCR4 in the formation of postburn hypertrophic_scar -LRB- HTS -RRB- .
22146760	0	CXCR4	142,147	SDF-1	136,141	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Transmyocardial drilling revascularization combined with heparinized bFGF-incorporating stent activates resident cardiac stem cells via SDF-1 / CXCR4 axis .
22169298	0	CXCR4	30,35	SDF-1	24,29	CXCR4	SDF-1	7852	6387	Gene	Gene	behavior|dep|START_ENTITY behavior|nmod|END_ENTITY	-LSB- Biological behavior of SDF-1 / CXCR4 in patients with myelodysplastic_syndrome -RSB- .
22417013	0	CXCR4	0,5	SDF-1	93,98	CXCR4	SDF-1	493676(Tax:9685)	493806(Tax:9685)	Gene	Gene	expression|nummod|START_ENTITY expression|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	CXCR4 expression in feline mammary_carcinoma cells : evidence of a proliferative role for the SDF-1 / CXCR4 axis .
22417013	0	CXCR4	99,104	SDF-1	93,98	CXCR4	SDF-1	493676(Tax:9685)	493806(Tax:9685)	Gene	Gene	axis|nsubj|START_ENTITY expression|parataxis|axis expression|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	CXCR4 expression in feline mammary_carcinoma cells : evidence of a proliferative role for the SDF-1 / CXCR4 axis .
22450749	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling END_ENTITY|appos|induces	SDF-1 / CXCR4 signaling induces pancreatic_cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway .
22451511	0	CXCR4	10,15	SDF-1	4,9	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	The SDF-1 / CXCR4 axis in stem cell preconditioning .
22541097	0	CXCR4	105,110	SDF-1	99,104	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY -RSB-|nsubj|axis Expression|parataxis|-RSB- Expression|nmod|END_ENTITY	-LSB- Expression of p57kip2 in patients with de novo myelodysplastic_syndrome and its relationship with SDF-1 / CXCR4 axis -RSB- .
22592891	0	CXCR4	60,65	SDF-1	54,59	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Long-term administration of AMD3100 , an antagonist of SDF-1 / CXCR4 signaling , alters fracture repair .
22727731	0	CXCR4	45,50	SDF-1	38,43	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY Role|dep|axis Role|nmod|END_ENTITY	Role of the stromal-derived_factor-1 -LRB- SDF-1 -RRB- - CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma .
22766125	0	CXCR4	57,62	SDF-1	31,36	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	chemokine|dobj|START_ENTITY chemokine|nsubj|Expression Expression|nmod|END_ENTITY	Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during mouse limb muscle development and regeneration .
22767589	0	CXCR4	27,32	SDF-1	21,26	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY required|nsubjpass|axis New|parataxis|required New|acl|insight insight|nmod|END_ENTITY	New insight into the SDF-1 / CXCR4 axis in a breast_carcinoma model : hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation .
22767589	0	CXCR4	27,32	SDF-1	95,100	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY axis|nmod|model model|dep|END_ENTITY	New insight into the SDF-1 / CXCR4 axis in a breast_carcinoma model : hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation .
22889515	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	signal|compound|START_ENTITY involved|nsubjpass|signal END_ENTITY|appos|involved	SDF-1 / CXCR4 signal is involved in decreased expression of p57kip2 in de novo MDS patients .
23259294	0	CXCR4	42,47	SDF-1	36,41	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY axis|dep|-LSB- -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression and significance of SDF-1 / CXCR4 biological axis in laryngeal_squamous_cell_carcinoma and lymph node metastasize -RSB- .
23289420	0	CXCR4	0,5	SDF-1	52,57	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	form|nsubj|START_ENTITY form|dobj|unit unit|nmod|CXCL12 CXCL12|compound|END_ENTITY	CXCR4 and CXCR7 form a functional receptor unit for SDF-1 / CXCL12 in primary rodent microglia .
23381805	0	CXCR4	125,130	SDF-1	119,124	CXCR4	SDF-1	7852	6387	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting avb3-mediated SDF-1 / CXCR4 signaling .
23544621	0	CXCR4	87,92	SDF-1	81,86	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY pathways|nsubj|axis stress|parataxis|pathways stress|acl:relcl|induces induces|ccomp|stem stem|nmod|END_ENTITY	Low-level shear stress induces human mesenchymal stem cell migration through the SDF-1 / CXCR4 axis via MAPK signaling pathways .
23601898	0	CXCR4	97,102	SDF-1	91,96	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Combination of vessel-targeting agents and fractionated radiation therapy : the role of the SDF-1 / CXCR4 pathway .
23710557	0	CXCR4	20,25	SDF-1	14,19	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY stem|nsubj|axis Expression|parataxis|stem Expression|nmod|END_ENTITY	Expression of SDF-1 / CXCR4 axis in bone marrow mesenchymal stem cells derived from rheumatoid_arthritis-usual_interstitial_pneumonia .
23740770	0	CXCR4	58,63	SDF-1	64,69	CXCR4	SDF-1	7852	6387	Gene	Gene	dimerization|nmod|START_ENTITY sulfation|nmod|dimerization role|nmod|sulfation role|dep|complex complex|compound|END_ENTITY	The role of tyrosine sulfation in the dimerization of the CXCR4 : SDF-1 complex .
24014104	0	CXCR4	80,85	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	internalization|compound|START_ENTITY angiogenesis|nmod|internalization angiogenesis|nsubj|restores restores|compound|END_ENTITY	SDF-1 restores angiogenesis synergistically with VEGF upon LDL exposure despite CXCR4 internalization and degradation .
24085800	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY promotes|nsubj|axis END_ENTITY|appos|promotes	SDF-1 / CXCR4 axis promotes directional migration of colorectal_cancer cells through upregulation of integrin avb6 .
24196072	0	CXCR4	121,126	SDF-1	115,120	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1 / CXCR4 axis .
24292718	0	CXCR4	61,66	SDF-1	25,30	CXCR4	SDF-1	7852	6387	Gene	Gene	sing|nsubj|START_ENTITY peculiarities|parataxis|sing peculiarities|nmod|system system|compound|END_ENTITY	The peculiarities of the SDF-1 / CXCL12 system : in some cells , CXCR4 and CXCR7 sing solos , in others , they sing duets .
24381939	0	CXCR4	84,89	SDF-1	78,83	CXCR4	SDF-1	7852	6387	Gene	Gene	START_ENTITY|dep|Enhancing Enhancing|advcl|targeting targeting|dobj|END_ENTITY	Enhancing the migration ability of mesenchymal stromal cells by targeting the SDF-1 / CXCR4 axis .
24399074	0	CXCR4	122,127	SDF-1	116,121	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Vandetanib-induced inhibition_of_neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1 / CXCR4 axis and matrix_metalloproteinase_14 .
24416254	0	CXCR4	51,56	SDF-1	26,31	CXCR4	SDF-1	7852	6387	Gene	Gene	Stromal_derived_factor-1|dep|START_ENTITY Stromal_derived_factor-1|appos|END_ENTITY	Stromal_derived_factor-1 -LRB- SDF-1 -RRB- and its receptors CXCR4 and CXCR7 in endometrial_cancer patients .
24505417	0	CXCR4	113,118	SDF-1	107,112	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Inhibition of angiogenesis , fibrosis and thrombosis by tetramethylpyrazine : mechanisms contributing to the SDF-1 / CXCR4 axis .
24626964	0	CXCR4	10,15	SDF-1	4,9	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	axis|compound|START_ENTITY regulates|nsubj|axis END_ENTITY|parataxis|regulates	The SDF-1 / CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute_pancreatitis .
24637920	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY preserves|nsubj|signaling END_ENTITY|appos|preserves	SDF-1 / CXCR4 signaling preserves microvascular integrity and renal function in chronic_kidney_disease .
24658853	0	CXCR4	10,15	SDF-1	4,9	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY induces|nsubj|axis END_ENTITY|parataxis|induces	The SDF-1 / CXCR4 axis induces epithelial mesenchymal transition in hepatocellular_carcinoma .
24695674	0	CXCR4	31,36	SDF-1	25,30	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|END_ENTITY	An important role of the SDF-1 / CXCR4 axis in chronic skin_inflammation .
24762228	0	CXCR4	38,43	SDF-1	31,36	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY Stromal_cell-derived_factor-1|dep|axis Stromal_cell-derived_factor-1|appos|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / CXCR4 axis enhances cellular invasion in ovarian_carcinoma cells via integrin b1 and b3 expressions .
24977448	1	CXCR4	74,79	SDF-1	68,73	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY Role|dep|axis Role|nmod|END_ENTITY	Role of the SDF-1 / CXCR4 axis in acute_myeloid_leukaemia -RSB- .
25072364	0	CXCR4	41,46	SDF-1	35,40	CXCR4	SDF-1	7852	6387	Gene	Gene	Expression|compound|START_ENTITY Alteration|parataxis|Expression Alteration|nmod|END_ENTITY	Chemotherapy-induced Alteration of SDF-1 / CXCR4 Expression in Bone Marrow-derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute_Lymphoblastic_Leukemia .
25130304	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	Axis|compound|START_ENTITY Cells|nsubj|Axis END_ENTITY|appos|Cells	SDF-1 / CXCR4 Axis in Tie2-lineage Cells Including Endothelial Progenitor Cells Contributes to Bone Fracture_Healing .
25150783	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	SDF-1 / CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal_cancer by activation of the Wnt/b-catenin signaling pathway .
25421212	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	Progression|compound|START_ENTITY END_ENTITY|dep|Progression	SDF-1 / CXCR4 Axis Regulates Cell Cycle Progression and Epithelial-Mesenchymal Transition via Up-regulation of Survivin in Glioblastoma .
25428386	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|appos|signaling	SDF-1 / CXCR4 signaling up-regulates survivin to regulate human sacral_chondrosarcoma cell cycle and epithelial-mesenchymal transition via ERK and PI3K/AKT pathway .
25775124	0	CXCR4	79,84	SDF-1	73,78	CXCR4	SDF-1	7852	6387	Gene	Gene	Signaling|compound|START_ENTITY Axis|nsubj|Signaling Migration|parataxis|Axis Migration|acl|Disrupting Disrupting|dobj|END_ENTITY	IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1 / CXCR4 Signaling Axis .
25784988	0	CXCR4	162,167	SDF-1	156,161	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	axis|nummod|START_ENTITY axis|dep|independent independent|nmod|END_ENTITY	Activation of protein kinase C enhanced movement ability and paracrine function of rat bone marrow mesenchymal stem cells partly at least independent of SDF-1 / CXCR4 axis and PI3K/AKT pathway .
25825165	0	CXCR4	99,104	SDF-1	93,98	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|nsubj|START_ENTITY delivery|parataxis|axis delivery|dep|exploitation exploitation|nmod|END_ENTITY	Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells : exploitation of SDF-1 / CXCR4 axis towards enhancing the efficacy of stem cells ' homing .
26026718	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	7852	6387	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	SDF-1 / CXCR4 promotes F5M2 osteosarcoma cell migration by activating the Wnt/b-catenin signaling pathway .
26074977	0	CXCR4	154,159	SDF-1	148,153	CXCR4	SDF-1	7852	6387	Gene	Gene	Improves|parataxis|START_ENTITY Improves|dep|Migration Migration|nmod|END_ENTITY	Ultrasound-Targeted Microbubble Destruction Improves the Migration and Homing of Mesenchymal Stem Cells after Myocardial_Infarction by Upregulating SDF-1 / CXCR4 : A Pilot Study .
26074989	0	CXCR4	41,46	SDF-1	35,40	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Induced|nsubj|Expression Effects|parataxis|Induced Effects|nmod|END_ENTITY	Effects of Astragaloside_IV on the SDF-1 / CXCR4 Expression in Atherosclerosis of apoE -LRB- - / - -RRB- Mice Induced by Hyperlipaemia .
26275042	0	CXCR4	150,155	SDF-1	144,149	CXCR4	SDF-1	7852	6387	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	Tetramethylpyrazine -LRB- TMP -RRB- , an Active Ingredient of Chinese Herb Medicine Chuanxiong , Attenuates the Degeneration of Trabecular Meshwork through SDF-1 / CXCR4 Axis .
26300925	0	CXCR4	6,11	SDF-1	0,5	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	MSCs|compound|START_ENTITY END_ENTITY|dep|MSCs	SDF-1 / CXCR4 Axis Promotes MSCs to Repair Liver_Injury Partially through Trans-Differentiation and Fusion with Hepatocytes .
26345294	0	CXCR4	50,55	SDF-1	121,126	CXCR4	SDF-1	7852	6387	Gene	Gene	cells|nummod|START_ENTITY cells|appos|responsiveness responsiveness|nmod|gradient gradient|compound|END_ENTITY	Dimethylsulphoxide -LRB- DMSO -RRB- increases percentage of CXCR4 + hematopoietic stem/progenitor cells , their responsiveness to an SDF-1 gradient , homing capacities and survival .
26345294	0	CXCR4	50,55	SDF-1	121,126	CXCR4	SDF-1	7852	6387	Gene	Gene	cells|nummod|START_ENTITY cells|appos|responsiveness responsiveness|nmod|gradient gradient|compound|END_ENTITY	Dimethylsulphoxide -LRB- DMSO -RRB- increases percentage of CXCR4 + hematopoietic stem/progenitor cells , their responsiveness to an SDF-1 gradient , homing capacities and survival .
26366086	0	CXCR4	18,23	SDF-1	12,17	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of SDF-1 / CXCR4 in the vasculogenesis and remodeling of cerebral_arteriovenous_malformation .
26398409	0	CXCR4	16,21	SDF-1	10,15	CXCR4	SDF-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	axis|nummod|START_ENTITY stem|nsubj|axis Effect|parataxis|stem Effect|nmod|END_ENTITY	Effect of SDF-1 / CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal_cord_injury .
26441982	0	CXCR4	43,48	SDF-1	37,42	CXCR4	SDF-1	7852	6387	Gene	Gene	Axis|compound|START_ENTITY Regulation|dep|Axis Regulation|nmod|END_ENTITY	Dipeptidyl_Peptidase-4 Regulation of SDF-1 / CXCR4 Axis : Implications for Cardiovascular_Disease .
26490988	0	CXCR4	10,15	SDF-1	4,9	CXCR4	SDF-1	7852	6387	Gene	Gene	chemokine|compound|START_ENTITY axis|nsubj|chemokine END_ENTITY|parataxis|axis	The SDF-1 / CXCR4 chemokine axis in uveal_melanoma cell proliferation and migration .
26578388	0	CXCR4	24,29	SDF-1	18,23	CXCR4	SDF-1	7852	6387	Gene	Gene	CXCR7|dep|START_ENTITY CXCR7|compound|END_ENTITY	Crosstalk between SDF-1 / CXCR4 and SDF-1 / CXCR7 in cardiac stem cell migration .
26851944	0	CXCR4	90,95	SDF-1	84,89	CXCR4	SDF-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Cancer-associated fibroblasts promote the progression of endometrial_cancer via the SDF-1 / CXCR4 axis .
27057951	0	CXCR4	116,121	SDF-1	110,115	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Cyclophilin_A modulates bone marrow-derived CD117 -LRB- + -RRB- cells and enhances ischemia-induced angiogenesis via the SDF-1 / CXCR4 axis .
9247593	0	CXCR4	118,123	SDF-1	14,19	CXCR4	SDF-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	precursors|nmod|START_ENTITY attracts|dobj|precursors attracts|nsubj|END_ENTITY	The chemokine SDF-1 , stromal_cell-derived_factor_1 , attracts early stage B cell precursors via the chemokine receptor CXCR4 .
21821779	0	CXCR4	6,11	STAT3	77,82	CXCR4	STAT3	12767(Tax:10090)	20848(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	SDF-1 / CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury .
22977534	0	CXCR4	16,21	STAT3	38,43	CXCR4	STAT3	7852	6774	Gene	Gene	Significance|nmod|START_ENTITY phosphorylated|nsubj|Significance phosphorylated|dobj|expression expression|compound|END_ENTITY	Significance of CXCR4 , phosphorylated STAT3 and VEGF-A expression in resected non-small_cell_lung_cancer .
21186999	0	CXCR4	25,30	Stromal-derived_factor-1	0,24	CXCR4	Stromal-derived factor-1	7852	6387	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|dep|signaling	Stromal-derived_factor-1 / CXCR4 signaling : indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow .
25562157	0	CXCR4	100,105	Stromal_Cell-Derived_Factor-1	61,90	CXCR4	Stromal Cell-Derived Factor-1	7852	6387	Gene	Gene	Viability|compound|START_ENTITY Viability|compound|END_ENTITY	Human Breast Adipose-Derived Stem Cells Transfected with the Stromal_Cell-Derived_Factor-1 Receptor CXCR4 Exhibit Enhanced Viability in Human Autologous Free Fat Grafts .
15542441	0	CXCR4	38,43	Stromal_cell-derived_factor-1	0,29	CXCR4	Stromal cell-derived factor-1	7852	6387	Gene	Gene	couple|compound|START_ENTITY plays|nsubj|couple \|ccomp|plays \|nsubj|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- \ CXCR4 couple plays multiple roles on haematopoietic progenitors at the border between the old cytokine and new chemokine worlds : survival , cell cycling and trafficking .
17038674	0	CXCR4	30,35	Stromal_cell-derived_factor-1	0,29	CXCR4	Stromal cell-derived factor-1	7852	6387	Gene	Gene	signaling|compound|START_ENTITY modifies|nsubj|signaling END_ENTITY|parataxis|modifies	Stromal_cell-derived_factor-1 / CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro .
19327121	0	CXCR4	52,57	Stromal_cell-derived_factor-1	0,29	CXCR4	Stromal cell-derived factor-1	7852	6387	Gene	Gene	susceptibility|dep|START_ENTITY END_ENTITY|dobj|susceptibility	Stromal_cell-derived_factor-1 but not its receptor , CXCR4 , gene variants increase susceptibility and pathological development of hepatocellular_carcinoma .
21567300	0	CXCR4	74,79	Stromal_cell-derived_factor-1	0,29	CXCR4	Stromal cell-derived factor-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY induces|nsubj|activation _|ccomp|induces _|nsubj|_ _|amod|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / chemokine _ -LRB- C-X-C_motif -RRB- _ receptor_4 -LRB- CXCR4 -RRB- axis activation induces intra-islet glucagon-like_peptide-1 -LRB- GLP-1 -RRB- production and enhances beta cell survival .
24762228	0	CXCR4	38,43	Stromal_cell-derived_factor-1	0,29	CXCR4	Stromal cell-derived factor-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY END_ENTITY|dep|axis	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / CXCR4 axis enhances cellular invasion in ovarian_carcinoma cells via integrin b1 and b3 expressions .
25138701	0	CXCR4	113,118	TGF-b1	0,6	CXCR4	TGF-b1	7852	7040	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	TGF-b1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression .
11146046	0	CXCR4	25,30	TNF-alpha	0,9	CXCR4	TNF-alpha	12767(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNF-alpha down-regulates CXCR4 expression in primary murine astrocytes .
16919488	0	CXCR4	0,5	T_cell_receptor	37,52	CXCR4	T cell receptor	7852	6962	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	CXCR4 physically associates with the T_cell_receptor to signal in T cells .
21306303	0	CXCR4	44,49	VEGF	14,18	CXCR4	VEGF	12767(Tax:10090)	22339(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of VEGF , MMP-9 and metastasis by CXCR4 in a prostate_cancer cell line .
25676691	0	CXCR4	28,33	VEGFR	0,5	CXCR4	VEGFR	7852	3791	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFbR signaling-dependent manner .
23809370	0	CXCR4	73,78	VEGFR1	81,87	CXCR4	VEGFR1	12767(Tax:10090)	14254(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	NSAID , aspirin delays gastric_ulcer_healing with reduced accumulation of CXCR4 -LRB- + -RRB- VEGFR1 -LRB- + -RRB- cells to the ulcer granulation tissues .
23982810	0	CXCR4	180,185	VEGFR1	173,179	CXCR4	VEGFR1	12767(Tax:10090)	14254(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vascular_endothelial_growth_factor_receptor_1 signaling facilitates gastric ulcer_healing and angiogenesis through the upregulation of epidermal_growth_factor expression on VEGFR1 + CXCR4 + cells recruited from bone marrow .
10233851	0	CXCR4	91,96	Vascular_endothelial_growth_factor	0,34	CXCR4	Vascular endothelial growth factor	7852	7422	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Vascular_endothelial_growth_factor and basic_fibroblast_growth_factor induce expression of CXCR4 on human endothelial cells : In vivo neovascularization induced by stromal-derived factor-1alpha .
12499259	0	CXCR4	130,135	Vascular_endothelial_growth_factor	0,34	CXCR4	Vascular endothelial growth factor	7852	7422	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Vascular_endothelial_growth_factor promotes breast_carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4 .
15178707	0	CXCR4	37,42	chemokine_receptor	43,61	CXCR4	chemokine receptor	7852	7852	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Lysophosphatidylcholine up-regulates CXCR4 chemokine_receptor expression in human CD4 T cells .
21448932	0	CXCR4	109,114	chemokine_receptor	115,133	CXCR4	chemokine receptor	7852	7852	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Acetyl-11-keto-b-boswellic_acid suppresses invasion of pancreatic_cancer cells through the downregulation of CXCR4 chemokine_receptor expression .
25460567	0	CXCR4	31,36	cxcl12	13,19	CXCR4	cxcl12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	indicates|nsubj|START_ENTITY indicates|advcl|Profiling Profiling|nmod|receptors receptors|amod|END_ENTITY	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
25460567	0	CXCR4	31,36	cxcl12	154,160	CXCR4	cxcl12	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	indicates|nsubj|START_ENTITY indicates|dobj|role role|nmod|cxcr7 cxcr7|nmod|activity activity|amod|END_ENTITY	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
23982810	0	CXCR4	180,185	epidermal_growth_factor	135,158	CXCR4	epidermal growth factor	12767(Tax:10090)	13645(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Vascular_endothelial_growth_factor_receptor_1 signaling facilitates gastric ulcer_healing and angiogenesis through the upregulation of epidermal_growth_factor expression on VEGFR1 + CXCR4 + cells recruited from bone marrow .
10229873	0	CXCR4	69,74	gp120	18,23	CXCR4	gp120	7852	3700	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10704341	0	CXCR4	71,76	gp120	175,180	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing apoptosis|nmod|cells induced|nsubjpass|apoptosis induced|nmod|glycoprotein glycoprotein|appos|END_ENTITY	Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human_immunodeficiency_virus_type_1 envelope glycoprotein -LRB- gp120 -RRB- .
10820198	0	CXCR4	66,71	gp120	0,5	CXCR4	gp120	7852	3700	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors .
11356952	0	CXCR4	110,115	gp120	79,84	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	receptor|compound|START_ENTITY Cooperation|nmod|receptor Cooperation|nmod|END_ENTITY	Cooperation of the V1/V2 and V3 domains of human_immunodeficiency_virus_type_1 gp120 for interaction with the CXCR4 receptor .
11462036	0	CXCR4	56,61	gp120	47,52	CXCR4	gp120	7852	3700	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of human_immunodeficiency_virus_type_1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome_c-mediated apoptosis independently of Fas signaling .
11591141	0	CXCR4	86,91	gp120	77,82	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	occurs|nmod|START_ENTITY occurs|nmod|engagement engagement|nmod|END_ENTITY	HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process .
11591370	0	CXCR4	46,51	gp120	78,83	CXCR4	gp120	7852	3700	Gene	Gene	association|nmod|START_ENTITY surface|dobj|association surface|nmod|END_ENTITY	Evidence for cell surface association between CXCR4 and ganglioside_GM3 after gp120 binding in SupT1 lymphoblastoid cells .
11595336	0	CXCR4	119,124	gp120	37,42	CXCR4	gp120	60628(Tax:10116)	155971(Tax:11676)	Gene	Gene	receptor|compound|START_ENTITY Evidence|nmod|receptor Evidence|dep|causes causes|nsubj|END_ENTITY	Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor .
12368322	0	CXCR4	125,130	gp120	88,93	CXCR4	gp120	7852	3700	Gene	Gene	binding|compound|START_ENTITY importance|nmod|binding Identification|nmod|importance Identification|nmod|glycoprotein glycoprotein|amod|END_ENTITY	Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 binding .
12402167	0	CXCR4	11,16	gp120	69,74	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	development|compound|START_ENTITY parallels|nsubj|development parallels|nmod|END_ENTITY	Functional CXCR4 receptor development parallels sensitivity to HIV-1 gp120 in cultured rat astroglial cells but not in cultured rat cortical neurons .
12502809	0	CXCR4	41,46	gp120	18,23	CXCR4	gp120	7852	3700	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|sites sites|amod|END_ENTITY	Identification of gp120 binding sites on CXCR4 by using CD4-independent human_immunodeficiency_virus_type_2 Env proteins .
14689450	0	CXCR4	23,28	gp120	80,85	CXCR4	gp120	7852	3700	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|neurotoxicity neurotoxicity|amod|END_ENTITY	The chemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gp120 neurotoxicity in cerebellar granule cells .
15113923	0	CXCR4	98,103	gp120	64,69	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	coreceptor|compound|START_ENTITY interaction|nmod|coreceptor interaction|nsubj|blocks blocks|amod|binding binding|nmod|END_ENTITY	CD4-induced T-20 binding to human_immunodeficiency_virus_type_1 gp120 blocks interaction with the CXCR4 coreceptor .
16400660	0	CXCR4	97,102	gp120	36,41	CXCR4	gp120	60628(Tax:10116)	155971(Tax:11676)	Gene	Gene	potentiation|nmod|START_ENTITY inhibits|dobj|potentiation inhibits|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 gp120 inhibits long-term potentiation via chemokine receptor CXCR4 in rat hippocampal slices .
16553776	0	CXCR4	74,79	gp120	6,11	CXCR4	gp120	60628(Tax:10116)	3700	Gene	Gene	potentials|nmod|START_ENTITY enhances|dobj|potentials enhances|nsubj|END_ENTITY	HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus .
18850076	0	CXCR4	0,5	gp120	87,92	CXCR4	gp120	7852	3700	Gene	Gene	antagonist|nummod|START_ENTITY blocks|nsubj|antagonist blocks|nmod|HIV HIV|nummod|END_ENTITY	CXCR4 receptor antagonist blocks cardiac myocyte p38 MAP kinase phosphorylation by HIV gp120 .
20835359	0	CXCR4	0,5	gp120	19,24	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	CXCR4 Tropic HIV-1 gp120 Inhibition of SDF-1a-Induced Chemotaxis Requires Lck and is Associated with Cofilin Phosphorylation .
21438014	0	CXCR4	51,56	gp120	6,11	CXCR4	gp120	60628(Tax:10116)	155971(Tax:11676)	Gene	Gene	current|nmod|START_ENTITY enhances|dobj|current enhances|nsubj|END_ENTITY	HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia .
22479424	0	CXCR4	145,150	gp120	39,44	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	interactions|nmod|START_ENTITY activation|nmod|interactions promotes|dobj|activation promotes|nsubj|END_ENTITY	X4 Human_immunodeficiency_virus_type_1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4 .
24048002	0	CXCR4	25,30	gp120	54,59	CXCR4	gp120	7852	155971(Tax:11676)	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|loop loop|compound|END_ENTITY	Molecular recognition of CXCR4 by a dual tropic HIV-1 gp120 V3 loop .
24451118	0	CXCR4	84,89	gp120	62,67	CXCR4	gp120	60628(Tax:10116)	3700	Gene	Gene	activity|compound|START_ENTITY induced|nmod|activity induced|nmod|END_ENTITY	HSV-mediated p55TNFSR reduces neuropathic_pain induced by HIV gp120 in rats through CXCR4 activity .
9653130	0	CXCR4	113,118	gp120	0,5	CXCR4	gp120	7852	3700	Gene	Gene	signaling|nmod|START_ENTITY antagonize|xcomp|signaling antagonize|nsubj|glycoproteins glycoproteins|amod|END_ENTITY	gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5 .
17916907	0	CXCR4	75,80	matrix_metalloproteinase-9	15,41	CXCR4	matrix metalloproteinase-9	7852	4318	Gene	Gene	pathway|nummod|START_ENTITY Involvement|dep|pathway Involvement|nmod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in stromal_cell-derived_factor-1 / CXCR4 pathway of lung_cancer metastasis .
20023696	0	CXCR4	102,107	miR-146a	135,143	CXCR4	miR-146a	7852	406938	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|advcl|upregulating upregulating|xcomp|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus-encoded viral FLICE inhibitory protein -LRB- vFLIP -RRB- K13 suppresses CXCR4 expression by upregulating miR-146a .
25705792	0	CXCR4	18,23	miR-146a	0,8	CXCR4	miR-146a	7852	406938	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1_infection of CD4 -LRB- + -RRB- T lymphocytes .
26095299	0	CXCR4	0,5	miR-146a	114,122	CXCR4	miR-146a	7852	406938	Gene	Gene	3|compound|START_ENTITY functions|nummod|3 functions|acl|regulating regulating|dobj|activity activity|amod|END_ENTITY	CXCR4 3 ` UTR functions as a ceRNA in promoting metastasis , proliferation and survival of MCF-7 cells by regulating miR-146a activity .
10381170	0	CXCR4	34,39	nuclear_respiratory_factor_1	69,97	CXCR4	nuclear respiratory factor 1	7852	4899	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	HTLV type I Tax activation of the CXCR4 promoter by association with nuclear_respiratory_factor_1 .
22541097	0	CXCR4	105,110	p57kip2	15,22	CXCR4	p57kip2	7852	1028	Gene	Gene	axis|compound|START_ENTITY -RSB-|nsubj|axis Expression|parataxis|-RSB- Expression|nmod|END_ENTITY	-LSB- Expression of p57kip2 in patients with de novo myelodysplastic_syndrome and its relationship with SDF-1 / CXCR4 axis -RSB- .
10382744	0	CXCR4	14,19	stromal_cell-derived_factor-1	38,67	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|receptor receptor|nmod|progenitors progenitors|amod|END_ENTITY	Expression of CXCR4 , the receptor for stromal_cell-derived_factor-1 on fetal and adult human lympho-hematopoietic progenitors .
10602415	0	CXCR4	41,46	stromal_cell-derived_factor-1	138,167	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	Overexpression|nmod|START_ENTITY associated|nsubjpass|Overexpression associated|nmod|response response|nmod|END_ENTITY	Overexpression of the chemokine receptor CXCR4 in B_cell_chronic_lymphocytic_leukemia is associated with increased functional response to stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
10997965	0	CXCR4	139,144	stromal_cell-derived_factor-1	43,72	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	response|nmod|START_ENTITY response|nmod|blasts blasts|nmod|correlates correlates|amod|END_ENTITY	Functional response of leukaemic blasts to stromal_cell-derived_factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic_leukaemia .
11591806	0	CXCR4	20,25	stromal_cell-derived_factor-1	60,89	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	role|nmod|START_ENTITY role|amod|END_ENTITY	A possible role for CXCR4 and its ligand , the CXC chemokine stromal_cell-derived_factor-1 , in the development of bone marrow metastases in neuroblastoma .
14555820	0	CXCR4	69,74	stromal_cell-derived_factor-1	14,43	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|SDF-1 SDF-1|amod|END_ENTITY	Production of stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- and expression of CXCR4 in human bone marrow endothelial cells .
15033938	0	CXCR4	13,18	stromal_cell-derived_factor-1	125,154	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	complex|compound|START_ENTITY binds|nsubj|complex binds|dobj|CXC CXC|amod|END_ENTITY	A syndecan-4 / CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC chemokine stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
16513519	0	CXCR4	30,35	stromal_cell-derived_factor-1	82,111	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	stimulates|nummod|START_ENTITY mesenchymal|nmod:npmod|stimulates molecule|amod|mesenchymal stem|nsubj|molecule stem|nmod|END_ENTITY	The surface adhesion molecule CXCR4 stimulates mesenchymal stem cell migration to stromal_cell-derived_factor-1 in vitro but does not decrease apoptosis under serum deprivation .
17016644	0	CXCR4	79,84	stromal_cell-derived_factor-1	49,78	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Epithelial-mesenchymal transition induced by the stromal_cell-derived_factor-1 / CXCR4 system in oral_squamous_cell_carcinoma cells .
17046575	0	CXCR4	142,147	stromal_cell-derived_factor-1	41,70	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	plays|nmod|START_ENTITY Cloning|parataxis|plays Cloning|dobj|END_ENTITY	Cloning and characterizing mutated human stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- : C-terminal alpha-helix of SDF-1alpha plays a critical role in CXCR4 activation and signaling , but not in CXCR4 binding affinity .
17916907	0	CXCR4	75,80	stromal_cell-derived_factor-1	45,74	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	pathway|nummod|START_ENTITY Involvement|dep|pathway Involvement|nmod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in stromal_cell-derived_factor-1 / CXCR4 pathway of lung_cancer metastasis .
18464929	0	CXCR4	82,87	stromal_cell-derived_factor-1	52,81	CXCR4	stromal cell-derived factor-1	12767(Tax:10090)	20315(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	p21Cip1 modulates arterial wound repair through the stromal_cell-derived_factor-1 / CXCR4 axis in mice .
18974109	0	CXCR4	125,130	stromal_cell-derived_factor-1	20,49	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	receptors|compound|START_ENTITY chemotaxis|nmod|receptors chemotaxis|amod|END_ENTITY	Bryostatin-5 blocks stromal_cell-derived_factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors .
19497995	0	CXCR4	78,83	stromal_cell-derived_factor-1	48,77	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	ligand/receptor|compound|START_ENTITY ligand/receptor|amod|END_ENTITY	The influence of tumor-host interactions in the stromal_cell-derived_factor-1 / CXCR4 ligand/receptor axis in determining metastatic risk in breast_cancer .
20484957	0	CXCR4	123,128	stromal_cell-derived_factor-1	93,122	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Pancreatic stellate cells increase the invasion of human pancreatic_cancer cells through the stromal_cell-derived_factor-1 / CXCR4 axis .
20558135	0	CXCR4	105,110	stromal_cell-derived_factor-1	75,104	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal_cell-derived_factor-1 / CXCR4 axis via Akt , ERK , and p38 signal transduction pathways .
22664794	0	CXCR4	164,169	stromal_cell-derived_factor-1	134,163	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Angiotensin_II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal_cell-derived_factor-1 / CXCR4 axis in intrahepatic_cholangiocarcinoma .
23576796	0	CXCR4	18,23	stromal_cell-derived_factor-1	101,130	CXCR4	stromal cell-derived factor-1	60628(Tax:10116)	24772(Tax:10116)	Gene	Gene	Overexpression|nmod|START_ENTITY promotes|nsubj|Overexpression promotes|nmod|gradient gradient|amod|END_ENTITY	Overexpression of CXCR4 in tracheal epithelial cells promotes their proliferation and migration to a stromal_cell-derived_factor-1 gradient .
9886389	0	CXCR4	116,121	stromal_cell-derived_factor-1	42,71	CXCR4	stromal cell-derived factor-1	7852	6387	Gene	Gene	regulation|nmod|START_ENTITY evidence|nmod|regulation inhibits|parataxis|evidence inhibits|advcl|END_ENTITY	TCR activation inhibits chemotaxis toward stromal_cell-derived_factor-1 : evidence for reciprocal regulation between CXCR4 and the TCR .
17553309	0	CXCR4	43,48	stromal_cell_derived_factor-1	13,42	CXCR4	stromal cell derived factor-1	7852	6387	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|END_ENTITY	-LSB- The role of stromal_cell_derived_factor-1 / CXCR4 biological axis in tumor metastasis of non-Hodgkin_lymphoma -RSB- .
15033938	0	CXCR4	13,18	syndecan-4	2,12	CXCR4	syndecan-4	7852	6385	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	A syndecan-4 / CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC chemokine stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
24738314	0	CXCR4	63,68	trefoil_factor_3	36,52	CXCR4	trefoil factor 3	7852	7033	Gene	Gene	axis|nummod|START_ENTITY axis|dep|-LSB- -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression and significance of trefoil_factor_3 and SDF-1 / CXCR4 biological axis in papillary_thyroid_carcinoma -RSB- .
16084492	0	CXCR4	33,38	vascular_endothelial_growth_factor	92,126	CXCR4	vascular endothelial growth factor	7852	7422	Gene	Gene	Activation|nmod|START_ENTITY promotes|nsubj|Activation promotes|dobj|production production|nmod|END_ENTITY	Activation of chemokine receptor CXCR4 in malignant_glioma cells promotes the production of vascular_endothelial_growth_factor .
21087342	0	CXCR4	18,23	vascular_endothelial_growth_factor	77,111	CXCR4	vascular endothelial growth factor	7852	7422	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	The expression of CXCR4 and its relationship with matrix_metalloproteinase-9 / vascular_endothelial_growth_factor in esophageal squamous_cell_cancer .
12354388	0	CXCR5	92,97	CD4	0,3	CXCR5	CD4	12145(Tax:10090)	12504(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY role|nmod|activation CD3|dep|role CD3|compound|END_ENTITY	CD4 + CD3 - cells induce Peyer 's patch development : role of alpha4beta1 integrin activation by CXCR5 .
16982935	0	CXCR5	57,62	CD4	63,66	CXCR5	CD4	643	920	Gene	Gene	center|compound|START_ENTITY center|compound|END_ENTITY	ICOS_deficiency is associated with a severe reduction of CXCR5 + CD4 germinal center Th cells .
18941193	0	CXCR5	167,172	CD4	156,159	CXCR5	CD4	12145(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
21270407	0	CXCR5	32,37	CD4	7,10	CXCR5	CD4	643	920	Gene	Gene	provide|nsubj|START_ENTITY express|ccomp|provide cells|ccomp|express cells|compound|END_ENTITY	Memory CD4 T cells that express CXCR5 provide accelerated help to B cells .
21471443	0	CXCR5	0,5	CD4	38,41	CXCR5	CD4	643	920	Gene	Gene	START_ENTITY|acl|expressing expressing|dobj|T T|compound|END_ENTITY	CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses .
22575453	0	CXCR5	38,43	CD4	31,34	CXCR5	CD4	643	920	Gene	Gene	CCR6|compound|START_ENTITY CCR6|nummod|END_ENTITY	Role of the frequency of blood CD4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- CCR6 -LRB- + -RRB- T cells in autoimmunity in patients with Sj gren 's syndrome .
23403044	0	CXCR5	17,22	CD4	6,9	CXCR5	CD4	643	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Blood CD4 + CD45RO + CXCR5 + T cells are decreased but partially functional in signal_transducer_and_activator_of_transcription_3 deficiency .
23527264	0	CXCR5	70,75	CD4	34,37	CXCR5	CD4	100515679	404704(Tax:9823)	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels END_ENTITY|ccomp|express	Rhesus_macaque lymph node PD-1 -LRB- hi -RRB- CD4 + T cells express high levels of CXCR5 and IL-21 and display a CCR7 -LRB- lo -RRB- ICOS+B cl6 + T-follicular helper -LRB- Tfh -RRB- cell phenotype .
23807677	0	CXCR5	31,36	CD4	26,29	CXCR5	CD4	643	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Association of peripheral CD4 + CXCR5 + T cells with chronic_lymphocytic_leukemia .
24291746	0	CXCR5	0,5	CD4	6,9	CXCR5	CD4	643	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CXCR5 + CD4 + follicular helper T cells accumulate in resting human lymph nodes and have superior B cell helper activity .
24333338	0	CXCR5	28,33	CD4	22,25	CXCR5	CD4	643	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	A higher frequency of CD4 CXCR5 T follicular helper cells in patients with newly diagnosed IgA_nephropathy .
24519063	0	CXCR5	31,36	CD4	27,30	CXCR5	CD4	643	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Upregulation of peripheral CD4 + CXCR5 + T cells in osteosarcoma .
24966908	0	CXCR5	4,9	CD4	0,3	CXCR5	CD4	643	920	Gene	Gene	helper|compound|START_ENTITY helper|compound|END_ENTITY	CD4 + CXCR5 + follicular helper T cells in salivary gland promote B cells maturation in patients with primary_Sjogren 's _ syndrome .
25042122	0	CXCR5	0,5	CD4	7,10	CXCR5	CD4	643	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CXCR5 + CD4 + T follicular helper cells participate in the pathogenesis of primary_biliary_cirrhosis .
25177353	0	CXCR5	97,102	CD4	87,90	CXCR5	CD4	643	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The effect of aging on the frequency , phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells : comparison of aged and young subjects .
25199644	0	CXCR5	74,79	CD4	52,55	CXCR5	CD4	643	920	Gene	Gene	START_ENTITY|dep|Bregs Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25351463	0	CXCR5	33,38	CD4	29,32	CXCR5	CD4	643	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Dysregulation of circulating CD4 + CXCR5 + T cells in type_2_diabetes_mellitus .
25654980	0	CXCR5	12,17	CD4	18,21	CXCR5	CD4	643	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating CXCR5 + CD4 + helper T cells in systemic_lupus_erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production .
26116502	0	CXCR5	77,82	CD4	95,98	CXCR5	CD4	701792(Tax:9544)	713807(Tax:9544)	Gene	Gene	+|compound|START_ENTITY Alum|nmod|+ Protein|nmod|Alum Codelivery|nmod|Protein Codelivery|dep|Responses Responses|nummod|END_ENTITY	Codelivery of Envelope Protein in Alum with MVA_Vaccine Induces CXCR3-Biased CXCR5 + and CXCR5 - CD4 T Cell Responses in Rhesus_Macaques .
26333070	0	CXCR5	12,17	CD4	18,21	CXCR5	CD4	643	920	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Cell Cell|nummod|END_ENTITY	Circulating CXCR5 + CD4 + T Follicular-Like Helper Cell and Memory B Cell Responses to Human_Papillomavirus Vaccines .
26425132	0	CXCR5	109,114	CD4	99,102	CXCR5	CD4	643	920	Gene	Gene	follicular|compound|START_ENTITY follicular|compound|END_ENTITY	Erratum to : The effect of aging on the frequency , phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells : comparison of aged and young subjects .
26559315	0	CXCR5	24,29	CD4	20,23	CXCR5	CD4	100515679	404704(Tax:9823)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Higher Frequency of CD4 + CXCR5 + ICOS+PD 1 + T Follicular Helper Cells in Patients With Infectious_Mononucleosis .
26818544	0	CXCR5	4,9	CD4	0,3	CXCR5	CD4	643	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
25199644	0	CXCR5	74,79	Foxp3	56,61	CXCR5	Foxp3	643	50943	Gene	Gene	START_ENTITY|dep|Bregs Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
16081804	0	CXCR5	24,29	ICOS	12,16	CXCR5	ICOS	12145(Tax:10090)	54167(Tax:10090)	Gene	Gene	helper|compound|START_ENTITY END_ENTITY|nmod|helper	The role of ICOS in the CXCR5 + follicular B helper T cell maintenance in vivo .
18941193	0	CXCR5	167,172	ICOS	161,165	CXCR5	ICOS	12145(Tax:10090)	54167(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
18941193	0	CXCR5	167,172	IL-17	149,154	CXCR5	IL-17	12145(Tax:10090)	16171(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
18056361	0	CXCR5	124,129	IL-21	106,111	CXCR5	IL-21	643	59067	Gene	Gene	cells|compound|START_ENTITY produced|nmod|cells END_ENTITY|acl|produced	Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells : predominant role of IL-21 produced by CXCR5 + T follicular helper cells .
26329514	0	CXCR5	13,18	IL-4	6,10	CXCR5	IL-4	643	3565	Gene	Gene	CD4|compound|START_ENTITY CD4|amod|END_ENTITY	Nasal IL-4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- CD4 -LRB- + -RRB- T follicular helper cell counts correlate with local IgE production in eosinophilic_nasal_polyps .
25172499	0	CXCR5	12,17	PD-1	18,22	CXCR5	PD-1	643	5133	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Circulating CXCR5 + PD-1 + response predicts influenza vaccine antibody responses in young adults but not elderly adults .
22079021	0	CXCR6	97,102	CCR5	104,108	CXCR6	CCR5	10663	1234	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	T lymphocyte recruitment into renal_cell_carcinoma tissue : a role for chemokine receptors CXCR3 , CXCR6 , CCR5 , and CCR6 .
23840334	0	CXCR6	19,24	CD4	41,44	CXCR6	CD4	10663	920	Gene	Gene	Roles|nmod|START_ENTITY END_ENTITY|nsubj|Roles	Distinct Roles for CXCR6 -LRB- + -RRB- and CXCR6 -LRB- - -RRB- CD4 -LRB- + -RRB- T Cells in the Pathogenesis of Chronic_Colitis .
15611250	0	CXCR6	9,14	CD8	43,46	CXCR6	CD8	10663	925	Gene	Gene	START_ENTITY|nmod|recruitment recruitment|nmod|+ +|compound|END_ENTITY	Role for CXCR6 in recruitment of activated CD8 + lymphocytes to inflamed liver .
20035869	0	CXCR6	14,19	CD8	23,26	CXCR6	CD8	10663	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression of CXCR6 on CD8 -LRB- + -RRB- T cells was up-regulated in allograft rejection .
24823625	0	CXCR6	23,28	CD8	77,80	CXCR6	CD8	10663	925	Gene	Gene	Required|nsubjpass|START_ENTITY Required|nmod|Maintenance Maintenance|nmod|Specific Specific|compound|END_ENTITY	The Chemokine Receptor CXCR6 Is Required for the Maintenance of Liver Memory CD8 + T Cells Specific for Infectious Pathogens .
22079021	0	CXCR6	97,102	CXCR3	90,95	CXCR6	CXCR3	10663	2833	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	T lymphocyte recruitment into renal_cell_carcinoma tissue : a role for chemokine receptors CXCR3 , CXCR6 , CCR5 , and CCR6 .
22287719	0	CXCR6	135,140	CXCR3	129,134	CXCR6	CXCR3	10663	2833	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Adjuvant immunotherapy of experimental_autoimmune_encephalomyelitis : immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3 + CXCR6 + and myelin-specific T cells to the draining lymph nodes rather than the central nervous system .
23142594	0	CXCR6	33,38	RANKL	0,5	CXCR6	RANKL	10663	8600	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	RANKL downregulates cell surface CXCR6 expression through JAK2/STAT3 signaling pathway during osteoclastogenesis .
20161793	0	CXCR7	0,5	CXCL12	35,41	CXCR7	CXCL12	57007	6387	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	CXCR7 functions as a scavenger for CXCL12 and CXCL11 .
20839032	0	CXCR7	17,22	CXCL12	0,6	CXCR7	CXCL12	57007	6387	Gene	Gene	chemokine|nsubj|START_ENTITY CXCR4|parataxis|chemokine CXCR4|compound|END_ENTITY	CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression .
21084856	0	CXCR7	39,44	CXCL12	22,28	CXCR7	CXCL12	57007	6387	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Expression of the new CXCL12 receptor , CXCR7 , in gliomas .
21300915	0	CXCR7	0,5	CXCL12	82,88	CXCR7	CXCL12	57007	6387	Gene	Gene	influences|nsubj|START_ENTITY influences|advcl|controlling controlling|dobj|abundance abundance|compound|END_ENTITY	CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity .
21470690	0	CXCR7	0,5	CXCL12	49,55	CXCR7	CXCL12	57007	6387	Gene	Gene	receptors|nsubj|START_ENTITY receptors|nmod|END_ENTITY	CXCR7 and syndecan-4 are potential receptors for CXCL12 in human cytotrophoblasts .
22088972	0	CXCR7	32,37	CXCL12	15,21	CXCR7	CXCL12	57007	6387	Gene	Gene	role|appos|START_ENTITY role|nmod|receptor receptor|compound|END_ENTITY	A role for the CXCL12 receptor , CXCR7 , in the pathogenesis of human pulmonary_vascular_disease .
22736769	0	CXCR7	49,54	CXCL12	32,38	CXCR7	CXCL12	57007	6387	Gene	Gene	residues|nummod|START_ENTITY depend|nmod|residues depend|nsubj|uptake uptake|nmod|END_ENTITY	Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues .
22987307	0	CXCR7	64,69	CXCL12	0,6	CXCR7	CXCL12	57007	6387	Gene	Gene	endocytotic|amod|START_ENTITY enhances|nmod|endocytotic enhances|nsubj|END_ENTITY	CXCL12 enhances human neural progenitor cell survival through a CXCR7 - and CXCR4-mediated endocytotic signaling pathway .
23153575	0	CXCR7	0,5	CXCL12	16,22	CXCR7	CXCL12	57007	6387	Gene	Gene	impact|nummod|START_ENTITY impact|nmod|biology biology|compound|END_ENTITY	CXCR7 impact on CXCL12 biology and disease .
23333329	0	CXCR7	0,5	CXCL12	39,45	CXCR7	CXCL12	57007	6387	Gene	Gene	agonists|compound|START_ENTITY inhibit|nsubj|agonists inhibit|dobj|function function|nmod|END_ENTITY	CXCR7 agonists inhibit the function of CXCL12 by down-regulation of CXCR4 .
24116850	0	CXCR7	26,31	CXCL12	63,69	CXCR7	CXCL12	12778(Tax:10090)	20315(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|levels levels|compound|END_ENTITY	Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels .
24174685	0	CXCR7	26,31	CXCL12	85,91	CXCR7	CXCL12	12778(Tax:10090)	20315(Tax:10090)	Gene	Gene	CXC_chemokine_receptor_7|appos|START_ENTITY affects|nsubj|CXC_chemokine_receptor_7 affects|advcl|regulating regulating|dobj|availability availability|compound|END_ENTITY	CXC_chemokine_receptor_7 -LRB- CXCR7 -RRB- affects the migration of GnRH neurons by regulating CXCL12 availability .
24497931	0	CXCR7	0,5	CXCL12	92,98	CXCR7	CXCL12	57007	6387	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|response response|nmod|END_ENTITY	CXCR7 is highly expressed in acute_lymphoblastic_leukemia and potentiates CXCR4 response to CXCL12 .
25084358	0	CXCR7	19,24	CXCL12	54,60	CXCR7	CXCL12	57007	6387	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells .
25833331	0	CXCR7	0,5	CXCL12	52,58	CXCR7	CXCL12	12778(Tax:10090)	20315(Tax:10090)	Gene	Gene	Migration|compound|START_ENTITY Migration|nmod|Independent Independent|compound|END_ENTITY	CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4 .
26428435	0	CXCR7	8,13	CXCL14	0,6	CXCR7	CXCL14	57007	9547	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	CXCL14 , CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing_sarcoma patients .
19380869	0	CXCR7	0,5	CXCR4	27,32	CXCR7	CXCR4	57007	7852	Gene	Gene	heterodimerizes|nsubj|START_ENTITY heterodimerizes|nmod|END_ENTITY	CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling .
21398406	0	CXCR7	38,43	EGFR	55,59	CXCR7	EGFR	57007	1956	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate_cancer growth .
25168820	0	CXCR7	23,28	EGFR	44,48	CXCR7	EGFR	57007	1956	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The chemokine receptor CXCR7 interacts with EGFR to promote breast_cancer cell proliferation .
22940879	0	CXCR7	34,39	Grk2	0,4	CXCR7	Grk2	57007	156	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Grk2 is an essential regulator of CXCR7 signalling in astrocytes .
26139098	0	CXCR7	19,24	MIF	0,3	CXCR7	MIF	57007	4282	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MIF interacts with CXCR7 to promote receptor internalization , ERK1/2 and ZAP-70 signaling , and lymphocyte chemotaxis .
26139098	0	CXCR7	19,24	MIF	0,3	CXCR7	MIF	57007	4282	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MIF interacts with CXCR7 to promote receptor internalization , ERK1/2 and ZAP-70 signaling , and lymphocyte chemotaxis .
24668750	0	CXCR7	80,85	cyclophilin_A	65,78	CXCR7	cyclophilin A	12778(Tax:10090)	268373(Tax:10090)	Gene	Gene	ubiquitination|dep|START_ENTITY ubiquitination|compound|END_ENTITY	SDF-1a induces differential trafficking of CXCR4-CXCR7 involving cyclophilin_A , CXCR7 ubiquitination and promotes platelet survival .
19835865	0	CXCR7	38,43	stromal-derived_factor-1	12,36	CXCR7	stromal-derived factor-1	57007	6387	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|END_ENTITY	The role of stromal-derived_factor-1 -- CXCR7 axis in development and cancer .
16005638	0	CXCR_4	39,45	P53	23,26	CXCR 4	P53	7852	7157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of neuronal P53 activity by CXCR_4 .
26042340	0	CXC_Chemokine_Receptor_7	21,45	CXCR4	87,92	CXC Chemokine Receptor 7	CXCR4	57007	7852	Gene	Gene	Ligands|compound|START_ENTITY Development|nmod|Ligands Development|dep|Switch Switch|nmod|Antagonists Antagonists|compound|END_ENTITY	Development of Novel CXC_Chemokine_Receptor_7 -LRB- CXCR7 -RRB- Ligands : Selectivity Switch from CXCR4 Antagonists with a Cyclic_Pentapeptide Scaffold .
23098564	0	CXC_chemokine_ligand_12	0,23	stromal_cell-derived_factor-1	24,53	CXC chemokine ligand 12	stromal cell-derived factor-1	6387	6387	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	CXC_chemokine_ligand_12 / stromal_cell-derived_factor-1 regulates cell adhesion in human colon_cancer cells by induction of intercellular_adhesion_molecule-1 .
18056360	0	CXC_chemokine_ligand_16	18,41	Th1	55,58	CXC chemokine ligand 16	Th1	66102(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Critical role for CXC_chemokine_ligand_16 -LRB- SR-PSOX -RRB- in Th1 response mediated by NKT cells .
15520172	0	CXC_chemokine_receptor_3	0,24	CD8	49,52	CXC chemokine receptor 3	CD8	2833	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CXC_chemokine_receptor_3 expression by activated CD8 + T cells is associated with survival in melanoma patients with stage_III_disease .
15802268	0	CXC_chemokine_receptor_4	58,82	Epidermal_growth_factor	0,23	CXC chemokine receptor 4	Epidermal growth factor	7852	1950	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Epidermal_growth_factor and hypoxia-induced expression of CXC_chemokine_receptor_4 on non-small_cell_lung_cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT / mammalian_target_of_rapamycin signaling pathway and activation of hypoxia_inducible_factor-1alpha .
20154716	0	CXC_chemokine_receptor_4	63,87	Transforming_growth_factor-beta1	0,32	CXC chemokine receptor 4	Transforming growth factor-beta1	7852	7040	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 upregulates the expression of CXC_chemokine_receptor_4 -LRB- CXCR4 -RRB- in human breast_cancer MCF-7 cells .
10712670	0	CXC_chemokine_receptor_4	0,24	interleukin-4	133,146	CXC chemokine receptor 4	interleukin-4	7852	3565	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	CXC_chemokine_receptor_4 expression and stromal cell-derived factor-1alpha-induced chemotaxis in CD4 + T lymphocytes are regulated by interleukin-4 and interleukin-10 .
15802268	0	CXC_chemokine_receptor_4	58,82	mammalian_target_of_rapamycin	178,207	CXC chemokine receptor 4	mammalian target of rapamycin	7852	2475	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Epidermal_growth_factor and hypoxia-induced expression of CXC_chemokine_receptor_4 on non-small_cell_lung_cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT / mammalian_target_of_rapamycin signaling pathway and activation of hypoxia_inducible_factor-1alpha .
20819433	0	CXC_chemokine_receptor_4_and_matrix_metalloproteinase-9	103,158	ulinastatin	11,22	CXC chemokine receptor 4 and matrix metalloproteinase-9	ulinastatin	17395(Tax:10090)	11699(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ulinastatin and cyclophosphamide on the growth of xenograft breast_cancer and expression of CXC_chemokine_receptor_4_and_matrix_metalloproteinase-9 in cancers .
22880115	0	CXC_chemokine_receptor_7	0,24	CXCR4	43,48	CXC chemokine receptor 7	CXCR4	12778(Tax:10090)	12767(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	CXC_chemokine_receptor_7 -LRB- CXCR7 -RRB- regulates CXCR4 protein expression and capillary tuft development in mouse kidney .
21518789	0	CXC_ligand_10	18,31	CXC_receptor_3	32,46	CXC ligand 10	CXC receptor 3	15945(Tax:10090)	12766(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	Critical role for CXC_ligand_10 / CXC_receptor_3 signaling in the murine neonatal response to sepsis .
12403783	0	CXC_ligand_9	140,152	monokine_induced_by_interferon-gamma	153,189	CXC ligand 9	monokine induced by interferon-gamma	4283	4283	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The transcriptional coactivator CREB-binding_protein cooperates with STAT1 and NF-kappa_B for synergistic transcriptional activation of the CXC_ligand_9 / monokine_induced_by_interferon-gamma gene .
21518789	0	CXC_receptor_3	32,46	CXC_ligand_10	18,31	CXC receptor 3	CXC ligand 10	12766(Tax:10090)	15945(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	Critical role for CXC_ligand_10 / CXC_receptor_3 signaling in the murine neonatal response to sepsis .
21567400	0	CXC_receptor_4	30,44	Stromal_cell-derived_factor-1	0,29	CXC receptor 4	Stromal cell-derived factor-1	7852	6387	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Stromal_cell-derived_factor-1 / CXC_receptor_4 and b1 integrin interaction regulates urokinase-type_plasminogen_activator expression in human colorectal_cancer cells .
21567400	0	CXC_receptor_4	30,44	urokinase-type_plasminogen_activator	83,119	CXC receptor 4	urokinase-type plasminogen activator	7852	5328	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Stromal_cell-derived_factor-1 / CXC_receptor_4 and b1 integrin interaction regulates urokinase-type_plasminogen_activator expression in human colorectal_cancer cells .
12121995	0	CXR	149,152	ALAS1	84,89	CXR	ALAS1	395439(Tax:9031)	552895(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Drugs mediate the transcriptional activation of the 5-aminolevulinic_acid synthase -LRB- ALAS1 -RRB- gene via the chicken xenobiotic-sensing nuclear receptor -LRB- CXR -RRB- .
11005856	0	CXR	0,3	pregnane_X_receptor	88,107	CXR	pregnane X receptor	395439(Tax:9031)	8856	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	CXR , a chicken xenobiotic-sensing orphan nuclear receptor , is related to both mammalian pregnane_X_receptor -LRB- PXR -RRB- and constitutive_androstane_receptor -LRB- CAR -RRB- .
19182210	0	CXXC5	67,72	RINF	26,30	CXXC5	RINF	51523	51523	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Functional involvement of RINF , retinoid-inducible_nuclear_factor -LRB- CXXC5 -RRB- , in normal and tumoral human myelopoiesis .
19557330	0	CXXC_finger_5_protein	4,25	p53	61,64	CXXC finger 5 protein	p53	51523	7157	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	The CXXC_finger_5_protein is required for DNA damage-induced p53 activation .
16788250	0	CYBA	22,26	p22phox	33,40	CYBA	p22phox	1535	1535	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	C242T polymorphism in CYBA gene -LRB- p22phox -RRB- and risk of coronary_artery_disease in a population of Caucasian Italians .
23755540	0	CYBA	74,78	p22phox	60,67	CYBA	p22phox	1535	1535	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Association between 242C _ > _ T polymorphism of NADPH oxidase p22phox gene -LRB- CYBA -RRB- and longevity in Russian population -RSB- .
24039708	0	CYBA	29,33	p22phox	20,27	CYBA	p22phox	1535	1535	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Relationship of the p22phox -LRB- CYBA -RRB- gene polymorphism C242T with risk of coronary_artery_disease : a meta-analysis .
24345348	0	CYBA	60,64	p22phox	46,53	CYBA	p22phox	1535	1535	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The A640G polymorphism in the NAD -LRB- P -RRB- H oxidase p22phox gene -LRB- CYBA -RRB- is associated with risk reduction of coronary_heart_disease : a meta-analysis .
20380705	0	CYC-B	68,73	lycopene_beta-cyclase	45,66	CYC-B	lycopene beta-cyclase	543649(Tax:4081)	544104(Tax:4081)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Isolation and functional characterization of lycopene_beta-cyclase -LRB- CYC-B -RRB- promoter from Solanum habrochaites .
7585620	0	CYCG1	65,70	cyclin_G1	54,63	CYCG1	cyclin G1	900	900	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|END_ENTITY	Retroviral vector-mediated gene transfer of antisense cyclin_G1 -LRB- CYCG1 -RRB- inhibits proliferation of human osteogenic_sarcoma cells .
17245118	0	CYFIP2	0,6	p53	17,20	CYFIP2	p53	26999	7157	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	CYFIP2 , a direct p53 target , is leptomycin-B sensitive .
1577698	0	CYI1	42,46	CYS3	36,40	CYI1	CYS3	851221(Tax:4932)	851221(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and characterization of the CYS3 -LRB- CYI1 -RRB- gene of Saccharomyces_cerevisiae .
26252513	0	CYK-4	23,28	RhoGAP	4,10	CYK-4	RhoGAP	29127	392	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
26252513	0	CYK-4	23,28	RhoGAP	4,10	CYK-4	RhoGAP	29127	392	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
22945935	0	CYK4	0,4	PAK1	29,33	CYK4	PAK1	29127	5058	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis .
1534806	0	CYL1	37,41	cyclin	42,48	CYL1	cyclin	12443(Tax:10090)	5111	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Suppression of growth factor-induced CYL1 cyclin gene expression by antiproliferative agents .
20593489	0	CYLD	18,22	Aurora-B	69,77	CYLD	Aurora-B	1540	9212	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B .
18245814	0	CYLD	18,22	Cylindromatosis	24,39	CYLD	Cylindromatosis	1540	1540	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role of CYLD -LRB- Cylindromatosis -RRB- as a deubiquitinating enzyme in vascular cells .
25389768	0	CYLD	0,4	IL-8	69,73	CYLD	IL-8	1540	3576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	CYLD negatively regulates nontypeable Haemophilus_influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK .
15496400	0	CYLD	61,65	JNK	23,26	CYLD	JNK	1540	5599	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of JNK signaling by the tumor suppressor CYLD .
21448133	0	CYLD	76,80	JNK	24,27	CYLD	JNK	1540	5599	Gene	Gene	inactivation|nmod|START_ENTITY requires|dobj|inactivation requires|nsubj|activation activation|compound|END_ENTITY	T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1 .
22157808	0	CYLD	100,104	LEF1	113,117	CYLD	LEF1	1540	51176	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Dysregulation of TNFa-induced necroptotic signaling in chronic_lymphocytic_leukemia : suppression of CYLD gene by LEF1 .
23405219	0	CYLD	0,4	RhoA	15,19	CYLD	RhoA	1540	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	CYLD regulates RhoA activity by modulating LARG ubiquitination .
19124656	0	CYLD	19,23	Snail	38,43	CYLD	Snail	1540	6615	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of CYLD expression by Snail promotes tumor progression in malignant_melanoma .
16500080	0	CYLD	67,71	TRPA1	0,5	CYLD	TRPA1	1540	8989	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD .
25234269	0	CYLD	52,56	cylindromatosis	35,50	CYLD	cylindromatosis	1540	1540	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel frameshift mutation in the cylindromatosis -LRB- CYLD -RRB- gene in a Chinese family with multiple familial trichoepithelioma .
11868391	0	CYP	33,36	cytochrome_P-450	15,31	CYP	cytochrome P-450	4051	4051	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	-LSB- Regulation of cytochrome_P-450 -LRB- CYP -RRB- genes by nuclear receptors -RSB- .
12389869	0	CYP	70,73	cytochrome_P450	53,68	CYP	cytochrome P450	4051	4051	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of xenobiotic-metabolizing cytochrome_P450 -LRB- CYP -RRB- enzymes in human lung .
15128046	0	CYP	31,34	cytochrome_P450	14,29	CYP	cytochrome P450	13079(Tax:10090)	13079(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Comparison of cytochrome_P450 -LRB- CYP -RRB- genes from the mouse and human genomes , including nomenclature recommendations for genes , pseudogenes and alternative-splice variants .
2993801	0	CYP1	114,118	CYP3	198,202	CYP1	CYP3	850958(Tax:4932)	854897(Tax:4932)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Regulation of the expression of iso 2-cytochrome c gene in S. _ cerevisiae : cloning of the positive regulatory gene CYP1 and identification of the region of its target sequence on the structural gene CYP3 .
2844525	0	CYP1	115,119	HAP1	109,113	CYP1	HAP1	850958(Tax:4932)	850958(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins : a binding site for the HAP1 -LRB- CYP1 -RRB- protein in the UAS region of the yeast catalase_T gene -LRB- CTT1 -RRB- .
7957173	0	CYP1	61,65	HAP1	66,70	CYP1	HAP1	850958(Tax:4932)	850958(Tax:4932)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	The DNA-binding domain of the yeast Saccharomyces_cerevisiae CYP1 -LRB- HAP1 -RRB- transcription factor possesses two zinc ions which are complexed in a zinc cluster .
8458333	0	CYP1	40,44	HAP1	45,49	HAP1	HAP1	850958(Tax:4932)	850958(Tax:4932)	Gene	Gene	activator|compound|START_ENTITY activator|appos|END_ENTITY	Evidence for an interaction between the CYP1 -LRB- HAP1 -RRB- activator and a cellular factor during heme-dependent transcriptional regulation in the yeast Saccharomyces_cerevisiae .
8394339	0	CYP11A	32,38	P450scc	40,47	CYP11A	P450scc	338048(Tax:9913)	338048(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of expression of the CYP11A -LRB- P450scc -RRB- gene in bovine ovarian luteal cells by forskolin and phorbol_esters .
10383457	0	CYP11A	71,77	Sp1	8,11	CYP11A	Sp1	338048(Tax:9913)	540741(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene .
10411633	0	CYP11A1	54,61	CYP11B1	15,22	CYP11A1	CYP11B1	1583	1584	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CYP11B1 -LRB- cytochrome P-45011 beta -RRB- with CYP11A1 -LRB- cytochrome_P-450scc -RRB- in COS-1 cells .
9481871	2	CYP11A1	139,146	CYP11B1	167,174	CYP11A1	CYP11B1	1583	1584	Gene	Gene	P450scc|appos|START_ENTITY inhibitors|nmod|P450scc activities|amod|inhibitors activities|appos|END_ENTITY	Antibodies as inhibitors of cytochrome P450scc -LRB- CYP11A1 -RRB- and P450 -LRB- 11 beta -RRB- -LRB- CYP11B1 -RRB- activities .
17615053	0	CYP11A1	75,82	CYP17A1	84,91	CYP11A1	CYP17A1	1583	1586	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP11A1	75,82	CYP1B1	51,57	CYP11A1	CYP1B1	1583	1545	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP11A1	75,82	CYP3A4	59,65	CYP11A1	CYP3A4	1583	1576	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP11A1	75,82	CYP3A5	67,73	CYP11A1	CYP3A5	1583	1577	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
8119986	0	CYP11A1	80,87	P450scc	89,96	CYP11A1	P450scc	1583	1583	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Actions of two different cAMP-responsive sequences and an enhancer of the human CYP11A1 -LRB- P450scc -RRB- gene in adrenal Y1 and placental JEG-3 cells .
19067654	0	CYP11A1	31,38	PIASy	0,5	CYP11A1	PIASy	1583	51588	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	PIASy inhibits LRH-1-dependent CYP11A1 expression by competing for SRC-1 binding .
8026494	0	CYP11A1	112,119	cytochrome_P450scc	92,110	CYP11A1	cytochrome P450scc	1583	1583	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulatory mechanisms of cAMP-dependent and cell-specific expression of human steroidogenic cytochrome_P450scc -LRB- CYP11A1 -RRB- gene .
19342447	0	CYP11A1	106,113	runx2	36,41	CYP11A1	runx2	13070(Tax:10090)	12393(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism , including CYP11A1 in osteoblasts .
1336011	0	CYP11B	96,102	Ad1	45,48	CYP11B	Ad1	1584	351	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Cooperative transcription activation between Ad1 , a CRE-like element , and other elements in the CYP11B gene promoter .
8784078	0	CYP11B	35,41	P450c11	43,50	CYP11B	P450c11	1584	1584	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	The human genome contains only two CYP11B -LRB- P450c11 -RRB- genes .
9331977	0	CYP11B1	102,109	11_beta-hydroxylase_cytochrome_P450	65,100	CYP11B1	11 beta-hydroxylase cytochrome P450	500892(Tax:10116)	500892(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of aldosterone_synthase_cytochrome_P450 _ -LRB- CYP11B2 -RRB- and 11_beta-hydroxylase_cytochrome_P450 -LRB- CYP11B1 -RRB- expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists .
10411633	0	CYP11B1	15,22	CYP11A1	54,61	CYP11B1	CYP11A1	1584	1583	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CYP11B1 -LRB- cytochrome P-45011 beta -RRB- with CYP11A1 -LRB- cytochrome_P-450scc -RRB- in COS-1 cells .
9481871	2	CYP11B1	167,174	CYP11A1	139,146	CYP11B1	CYP11A1	1584	1583	Gene	Gene	activities|appos|START_ENTITY activities|amod|inhibitors inhibitors|nmod|P450scc P450scc|appos|END_ENTITY	Antibodies as inhibitors of cytochrome P450scc -LRB- CYP11A1 -RRB- and P450 -LRB- 11 beta -RRB- -LRB- CYP11B1 -RRB- activities .
15134825	0	CYP11B1	120,127	CYP11B2	87,94	CYP11B1	CYP11B2	1584	1585	Gene	Gene	aldosterone_synthase|appos|START_ENTITY aldosterone_synthase|appos|END_ENTITY	Development of test systems for the discovery of selective human aldosterone_synthase -LRB- CYP11B2 -RRB- and 11beta-hydroxylase -LRB- CYP11B1 -RRB- inhibitors .
18252953	0	CYP11B1	73,80	CYP11B2	108,115	CYP11B1	CYP11B2	500892(Tax:10116)	24294(Tax:10116)	Gene	Gene	11beta-hydroxylase|appos|START_ENTITY 11beta-hydroxylase|appos|END_ENTITY	Effects of ACTH , dexamethasone , and adrenalectomy on 11beta-hydroxylase -LRB- CYP11B1 -RRB- and aldosterone_synthase -LRB- CYP11B2 -RRB- gene expression in the rat central nervous system .
7779756	0	CYP11B1	62,69	CYP11B2	97,104	CYP11B1	CYP11B2	500892(Tax:10116)	24294(Tax:10116)	Gene	Gene	cytochrome_P450_11_beta-hydroxylase|appos|START_ENTITY cytochrome_P450_11_beta-hydroxylase|appos|END_ENTITY	Stable expression of rat cytochrome_P450_11_beta-hydroxylase -LRB- CYP11B1 -RRB- and aldosterone_synthase -LRB- CYP11B2 -RRB- in MA-10 cells .
8123004	0	CYP11B1	67,74	CYP11B2	101,108	CYP11B1	CYP11B2	500892(Tax:10116)	24294(Tax:10116)	Gene	Gene	exons|nmod|START_ENTITY containing|dobj|exons containing|nmod|enzyme enzyme|compound|END_ENTITY	The hybrid rat cytochrome_P450 containing the first 5 exons of the CYP11B1 and last 4 exons from the CYP11B2 enzyme retains 11 beta-hydroxylase activity , but the alternative hybrid is inactive .
9408886	0	CYP11B1	35,42	CYP11B2	70,77	CYP11B1	CYP11B2	1584	1585	Gene	Gene	beta-hydroxylase|appos|START_ENTITY beta-hydroxylase|appos|END_ENTITY	Expression of 11 beta-hydroxylase -LRB- CYP11B1 -RRB- and aldosterone_synthase -LRB- CYP11B2 -RRB- in the human fetal adrenal .
21468188	0	CYP11B2	27,34	Aldosterone_Synthase	0,20	CYP11B2	Aldosterone Synthase	1585	1585	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Aldosterone_Synthase Gene -LRB- CYP11B2 -RRB- Polymorphism in Korean End-Stage Renal_Disease Patients on Hemodialysis .
25957425	0	CYP11B2	21,28	Aldosterone_Synthase	0,20	CYP11B2	Aldosterone Synthase	1585	1585	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	Aldosterone_Synthase CYP11B2 Gene Promoter Polymorphism in a Turkish Population With Chronic_Kidney_Disease .
26403853	0	CYP11B2	114,121	Aldosterone_Synthase	92,112	CYP11B2	Aldosterone Synthase	24294(Tax:10116)	24294(Tax:10116)	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Discovery of 4-Aryl-5 ,6,7,8 - tetrahydroisoquinolines as Potent , Selective , and Orally Active Aldosterone_Synthase -LRB- CYP11B2 -RRB- Inhibitors : In Vivo Evaluation in Rodents and Cynomolgus_Monkeys .
10608469	0	CYP11B2	27,34	Aldosterone_synthase	0,20	CYP11B2	Aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-344T polymorphism in Caucasians from the Berlin Salt-Sensitivity Trial -LRB- BeSST -RRB- .
11693765	0	CYP11B2	22,29	Aldosterone_synthase	0,20	CYP11B2	Aldosterone synthase	1585	1585	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Aldosterone_synthase -LRB- CYP11B2 -RRB- -344 _ C/T polymorphism is associated with left ventricular structure in human arterial hypertension .
11725161	0	CYP11B2	27,34	Aldosterone_synthase	0,20	CYP11B2	Aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-334T polymorphism , ambulatory blood pressure and nocturnal decline in blood pressure in the general Japanese population : the Ohasama Study .
15361760	0	CYP11B2	27,34	Aldosterone_synthase	0,20	CYP11B2	Aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- C-344T polymorphism , plasma aldosterone , renin activity and blood pressure in a multi-ethnic population .
16759311	0	CYP11B2	22,29	Aldosterone_synthase	0,20	CYP11B2	Aldosterone synthase	1585	1585	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Aldosterone_synthase -LRB- CYP11B2 -RRB- -344 T/C polymorphism is not associated with the initiation and progression of diabetic_nephropathy in Caucasian Type 1 diabetic patients .
20176774	0	CYP11B2	27,34	Aldosterone_synthase	0,20	CYP11B2	Aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aldosterone_synthase gene -LRB- CYP11B2 -RRB- promoter polymorphism as a risk factor for ischaemic_stroke in Tunisian Arabs .
15134825	0	CYP11B2	87,94	CYP11B1	120,127	CYP11B2	CYP11B1	1585	1584	Gene	Gene	aldosterone_synthase|appos|START_ENTITY aldosterone_synthase|appos|END_ENTITY	Development of test systems for the discovery of selective human aldosterone_synthase -LRB- CYP11B2 -RRB- and 11beta-hydroxylase -LRB- CYP11B1 -RRB- inhibitors .
18252953	0	CYP11B2	108,115	CYP11B1	73,80	CYP11B2	CYP11B1	24294(Tax:10116)	500892(Tax:10116)	Gene	Gene	11beta-hydroxylase|appos|START_ENTITY 11beta-hydroxylase|appos|END_ENTITY	Effects of ACTH , dexamethasone , and adrenalectomy on 11beta-hydroxylase -LRB- CYP11B1 -RRB- and aldosterone_synthase -LRB- CYP11B2 -RRB- gene expression in the rat central nervous system .
7779756	0	CYP11B2	97,104	CYP11B1	62,69	CYP11B2	CYP11B1	24294(Tax:10116)	500892(Tax:10116)	Gene	Gene	cytochrome_P450_11_beta-hydroxylase|appos|START_ENTITY cytochrome_P450_11_beta-hydroxylase|appos|END_ENTITY	Stable expression of rat cytochrome_P450_11_beta-hydroxylase -LRB- CYP11B1 -RRB- and aldosterone_synthase -LRB- CYP11B2 -RRB- in MA-10 cells .
8123004	0	CYP11B2	101,108	CYP11B1	67,74	CYP11B2	CYP11B1	24294(Tax:10116)	500892(Tax:10116)	Gene	Gene	enzyme|compound|START_ENTITY containing|nmod|enzyme containing|dobj|exons exons|nmod|END_ENTITY	The hybrid rat cytochrome_P450 containing the first 5 exons of the CYP11B1 and last 4 exons from the CYP11B2 enzyme retains 11 beta-hydroxylase activity , but the alternative hybrid is inactive .
9408886	0	CYP11B2	70,77	CYP11B1	35,42	CYP11B2	CYP11B1	1585	1584	Gene	Gene	beta-hydroxylase|appos|START_ENTITY beta-hydroxylase|appos|END_ENTITY	Expression of 11 beta-hydroxylase -LRB- CYP11B1 -RRB- and aldosterone_synthase -LRB- CYP11B2 -RRB- in the human fetal adrenal .
11026332	0	CYP11B2	1,8	CYP17	10,15	CYP11B2	CYP17	1585	1586	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- CYP11B2 , CYP17 -RSB- .
26471128	0	CYP11B2	40,47	Klotho	15,21	CYP11B2	Klotho	13072(Tax:10090)	16591(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis .
1346492	0	CYP11B2	116,123	P-450C18	101,109	CYP11B2	P-450C18	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Congenitally defective aldosterone biosynthesis in humans : the involvement of point mutations of the P-450C18 gene -LRB- CYP11B2 -RRB- in CMO_II_deficient patients .
8439335	0	CYP11B2	94,101	P-450C18	79,87	CYP11B2	P-450C18	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Congenitally defective aldosterone biosynthesis in humans : inactivation of the P-450C18 gene -LRB- CYP11B2 -RRB- due to nucleotide deletion in CMO_I_deficient patients .
10577993	0	CYP11B2	42,49	aldosterone_synthase	20,40	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Joint effects of an aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism and classic risk factors on risk of myocardial_infarction .
10720582	0	CYP11B2	40,47	aldosterone_synthase	18,38	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of the aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism in patients with myocardial_infarction .
11422117	0	CYP11B2	60,67	aldosterone_synthase	33,53	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An influence of variation in the aldosterone_synthase gene -LRB- CYP11B2 -RRB- on corticosteroid responses to ACTH in normal human subjects .
11701710	0	CYP11B2	82,89	aldosterone_synthase	60,80	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Congenital hyperreninemic_hypoaldosteronism unlinked to the aldosterone_synthase -LRB- CYP11B2 -RRB- gene .
11728005	0	CYP11B2	36,43	aldosterone_synthase	14,34	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotypes of aldosterone_synthase -LRB- CYP11B2 -RRB- gene in the general population of Japan : the Ohasama study .
12433910	0	CYP11B2	42,49	aldosterone_synthase	20,40	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism and left ventricular volume in patients with dilated_cardiomyopathy .
12750023	0	CYP11B2	23,30	aldosterone_synthase	32,52	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of selective CYP11B2 -LRB- aldosterone_synthase -RRB- inhibitors for the therapy of congestive_heart_failure and myocardial_fibrosis .
12817181	0	CYP11B2	49,56	aldosterone_synthase	22,42	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|amod|END_ENTITY	Haplotype analysis of aldosterone_synthase gene -LRB- CYP11B2 -RRB- polymorphisms shows association with essential hypertension .
14736447	0	CYP11B2	42,49	aldosterone_synthase	20,40	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between aldosterone_synthase -LRB- CYP11B2 -RRB- polymorphism and left ventricular mass in human essential hypertension .
15223724	0	CYP11B2	59,66	aldosterone_synthase	24,44	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Association of -344 / T/C aldosterone_synthase polymorphism -LRB- CYP11B2 -RRB- with left ventricular structure and humoral parameters in young normotensive men .
15230231	0	CYP11B2	49,56	aldosterone_synthase	22,42	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Promoter variants of aldosterone_synthase gene -LRB- CYP11B2 -RRB- and salt-sensitivity of blood pressure -RSB- .
1594605	0	CYP11B2	23,30	aldosterone_synthase	32,52	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the human CYP11B2 -LRB- aldosterone_synthase -RRB- gene causing corticosterone methyloxidase II deficiency .
17261471	0	CYP11B2	66,73	aldosterone_synthase	39,59	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-344 C/T Variant in the promoter of the aldosterone_synthase gene -LRB- CYP11B2 -RRB- is associated with metabolic_syndrome in men .
18202594	0	CYP11B2	72,79	aldosterone_synthase	45,65	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The role of the -344 C/T polymorphism of the aldosterone_synthase gene -LRB- CYP11B2 -RRB- in cardiovascular_diseases -RSB- .
18710464	0	CYP11B2	58,65	aldosterone_synthase	36,56	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of genetic variation in the aldosterone_synthase -LRB- CYP11B2 -RRB- gene on enzyme function .
19407459	0	CYP11B2	41,48	aldosterone_synthase	20,40	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Association between aldosterone_synthase CYP11B2 polymorphism and essential hypertension in Chinese : a meta-analysis .
21092623	0	CYP11B2	38,45	aldosterone_synthase	16,36	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	-LSB- Association of aldosterone_synthase -LRB- CYP11B2 -RRB- gene -344 T/C polymorphism with essential hypertension in Mongolian nationality -RSB- .
23681285	0	CYP11B2	37,44	aldosterone_synthase	15,35	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of aldosterone_synthase -LRB- CYP11B2 -RRB- gene -344 T/C polymorphism with the risk of primary chronic glomerulonephritis in the Polish population .
25143332	0	CYP11B2	37,44	aldosterone_synthase	15,35	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism with IgA_nephropathy risk and progression of IgA_nephropathy .
25785110	0	CYP11B2	48,55	aldosterone_synthase	27,47	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Associations between human aldosterone_synthase CYP11B2 -LRB- -344 T/C -RRB- gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension .
9745430	0	CYP11B2	111,118	aldosterone_synthase	89,109	CYP11B2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Familial_hyperaldosteronism_type_II : description of a large kindred and exclusion of the aldosterone_synthase -LRB- CYP11B2 -RRB- gene .
11026332	0	CYP17	10,15	CYP11B2	1,8	CYP17	CYP11B2	1586	1585	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- CYP11B2 , CYP17 -RSB- .
17167982	0	CYP17	28,33	CYP19	67,72	CYP17	CYP19	1586	1588	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	The T/C polymorphism of the CYP17 gene and G/A polymorphism of the CYP19 gene in endometrial_cancer .
10463580	0	CYP17	30,35	Cytochrome_P450c17alpha	0,23	CYP17	Cytochrome P450c17alpha	1586	1586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cytochrome_P450c17alpha gene -LRB- CYP17 -RRB- polymorphism predicts use of hormone replacement therapy .
9485002	0	CYP17	30,35	Cytochrome_P450c17alpha	0,23	CYP17	Cytochrome P450c17alpha	1586	1586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cytochrome_P450c17alpha gene -LRB- CYP17 -RRB- polymorphism is associated with serum estrogen and progesterone concentrations .
17434514	0	CYP17	32,37	P450c17	23,30	CYP17	P450c17	1586	1586	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of P450c17 -LRB- CYP17 -RRB- during testicular formation in the frog .
11303586	0	CYP17	45,50	SRD5A2	73,79	CYP17	SRD5A2	1586	6716	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The association between polymorphisms in the CYP17 and 5alpha-reductase -LRB- SRD5A2 -RRB- genes and serum androgen concentrations in men .
22174412	0	CYP17	58,63	androgen_receptor	21,38	CYP17	androgen receptor	1586	367	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Direct regulation of androgen_receptor activity by potent CYP17 inhibitors in prostate_cancer cells .
22924551	0	CYP17	69,74	androgen_receptor	9,26	CYP17	androgen receptor	1586	367	Gene	Gene	inhibitors/antiandrogens|nummod|START_ENTITY hypothesis|nmod|inhibitors/antiandrogens flexibility|dep|hypothesis flexibility|compound|END_ENTITY	Modeling androgen_receptor flexibility : a binding mode hypothesis of CYP17 inhibitors/antiandrogens for prostate_cancer therapy .
15609124	0	CYP17	75,80	cytochrome_P450_c17alpha	49,73	CYP17	cytochrome P450 c17alpha	1586	1586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the T27C polymorphism in the cytochrome_P450_c17alpha -LRB- CYP17 -RRB- gene and risk factors for breast_cancer .
7629254	0	CYP17	94,99	cytochrome_P450c17	74,92	CYP17	cytochrome P450c17	1586	1586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Seventeen_alpha-hydroxylase_deficiency with one base pair deletion of the cytochrome_P450c17 -LRB- CYP17 -RRB- gene .
9250356	0	CYP17	41,46	cytochrome_P450c17	21,39	CYP17	cytochrome P450c17	1586	1586	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A new variant of the cytochrome_P450c17 -LRB- CYP17 -RRB- gene mutation in three patients with 17 alpha-hydroxylase_deficiency .
11341336	0	CYP17	58,63	cytochrome_P450c17alpha	33,56	CYP17	cytochrome P450c17alpha	1586	1586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common promotor variant in the cytochrome_P450c17alpha -LRB- CYP17 -RRB- gene is associated with bioavailability testosterone levels and bone size in men .
14995917	0	CYP17	53,58	cytochrome_P450c17alpha	23,46	CYP17	cytochrome P450c17alpha	1586	1586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A possible role of the cytochrome_P450c17alpha gene -LRB- CYP17 -RRB- polymorphism in the pathobiology of uterine leiomyomas from black_South African women : a pilot study .
17615053	0	CYP17A1	84,91	CYP11A1	75,82	CYP17A1	CYP11A1	1586	1583	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP17A1	84,91	CYP1B1	51,57	CYP17A1	CYP1B1	1586	1545	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP17A1	84,91	CYP3A4	59,65	CYP17A1	CYP3A4	1586	1576	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP17A1	84,91	CYP3A5	67,73	CYP17A1	CYP3A5	1586	1577	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
21074531	0	CYP17A1	107,114	P450c17	84,91	CYP17A1	P450c17	281739(Tax:9913)	281739(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The bovine genome contains three differentially methylated paralogous copies of the P450c17 encoding gene -LRB- CYP17A1 -RRB- .
17167982	0	CYP19	67,72	CYP17	28,33	CYP19	CYP17	1588	1586	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	The T/C polymorphism of the CYP17 gene and G/A polymorphism of the CYP19 gene in endometrial_cancer .
12130549	0	CYP19	129,134	cytochrome_P450	112,127	CYP19	cytochrome P450	1588	1588	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ligands for the peroxisomal_proliferator-activated_receptor_gamma and the retinoid_X_receptor inhibit aromatase cytochrome_P450 -LRB- CYP19 -RRB- expression mediated by promoter II in human breast adipose .
8808317	0	CYP19	94,99	cytochrome_P450	77,92	CYP19	cytochrome P450	1588	1588	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome_P450 -LRB- CYP19 -RRB- gene in aromatase-expressing human cells by competitive RT-PCR .
8923826	0	CYP19	71,76	cytochrome_P450	54,69	CYP19	cytochrome P450	1588	1588	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Use of alternative promoters to express the aromatase cytochrome_P450 -LRB- CYP19 -RRB- gene in breast adipose tissues of cancer-free_and_breast_cancer patients .
8989235	0	CYP19	68,73	cytochrome_P450	51,66	CYP19	cytochrome P450	1588	1588	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternatively spliced transcripts of the aromatase cytochrome_P450 -LRB- CYP19 -RRB- gene in adipose tissue of women .
22001251	0	CYP19	106,111	cytochrome_P450arom	85,104	CYP19	cytochrome P450arom	1588	1588	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Halowax 1051 affects steroidogenesis , 17b-hydroxysteroid dehydrogenase -LRB- 17b-HSD -RRB- and cytochrome_P450arom -LRB- CYP19 -RRB- activity , and protein expression in porcine ovarian follicles .
16394175	0	CYP19	84,89	epidermal_growth_factor	10,33	CYP19	epidermal growth factor	1588	1950	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor and prostaglandin on the expression of aromatase -LRB- CYP19 -RRB- in human adrenocortical_carcinoma cell line NCI-H295R cells .
14508827	0	CYP19	50,55	estrogen_receptor_alpha	25,48	CYP19	estrogen receptor alpha	1588	2099	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of estrogen_receptor_alpha , CYP19 , catechol-O-methyltransferase are associated with familial_prostate_carcinoma risk in a Japanese population .
26252353	0	CYP19A1	20,27	RRM1	0,4	CYP19A1	RRM1	1588	6240	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	CYP19A1	20,27	RRM1	0,4	CYP19A1	RRM1	1588	6240	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26191232	0	CYP19A1	22,29	S4646	0,5	CYP19A1	S4646	1588	1080844(Tax:198215)	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	S4646 polymorphism in CYP19A1 gene is associated with the efficacy of hormone therapy in early breast_cancer .
26252353	0	CYP19A1	20,27	TOP2A	13,18	CYP19A1	TOP2A	1588	7153	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	CYP19A1	20,27	TOP2A	13,18	CYP19A1	TOP2A	1588	7153	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	CYP19A1	20,27	TUBB3	6,11	CYP19A1	TUBB3	1588	10381	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	CYP19A1	20,27	TUBB3	6,11	CYP19A1	TUBB3	1588	10381	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
23085504	0	CYP19A1	99,106	WSTF	85,89	CYP19A1	WSTF	1588	9031	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Vitamin_D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase .
15178024	0	CYP1A	31,36	cytochrome_P450_1A	11,29	CYP1A	cytochrome P450 1A	100125806(Tax:8090)	100125806(Tax:8090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Cloning of cytochrome_P450_1A -LRB- CYP1A -RRB- genes from the hermaphrodite fish Rivulus_marmoratus and the Japanese_medaka Oryzias_latipes .
23178197	0	CYP1A	57,62	cytochrome_P450_1A	37,55	CYP1A	cytochrome P450 1A	100125806(Tax:8090)	100125806(Tax:8090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of biomarker potential of cytochrome_P450_1A -LRB- CYP1A -RRB- gene in the marine medaka , Oryzias melastigma exposed to water-accommodated_fractions -LRB- WAFs -RRB- of Iranian crude oil .
11090948	0	CYP1A1	3,9	AHR	38,41	CYP1A1	AHR	1543	196	Gene	Gene	induction|nsubj|START_ENTITY induction|acl|related related|nmod|END_ENTITY	Is CYP1A1 induction always related to AHR signaling pathway ?
11186136	0	CYP1A1	46,52	AHR	109,112	CYP1A1	AHR	1543	196	Gene	Gene	inducibility|nmod|START_ENTITY phenotype|nmod|inducibility ascribable|nsubj|phenotype ascribable|nmod|polymorphisms polymorphisms|nmod|ARNT ARNT|compound|END_ENTITY	An uncommon phenotype of poor inducibility of CYP1A1 in human lung is not ascribable to polymorphisms in the AHR , ARNT , or CYP1A1 genes .
23528250	0	CYP1A1	118,124	AHR	54,57	CYP1A1	AHR	1543	196	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Genetic association of aromatic_hydrocarbon receptor -LRB- AHR -RRB- and cytochrome_P450 , _ family_1 , subfamily_A , polypeptide_1 -LRB- CYP1A1 -RRB- polymorphisms with dioxin blood concentrations among pregnant Japanese women .
9170146	0	CYP1A1	99,105	AHR	19,22	CYP1A1	AHR	1543	196	Gene	Gene	inducibility|compound|START_ENTITY gene|nmod|inducibility gene|appos|END_ENTITY	Human Ah_receptor -LRB- AHR -RRB- gene : localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility .
10631103	0	CYP1A1	13,19	AhR	44,47	CYP1A1	AhR	1543	196	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|pathway pathway|compound|END_ENTITY	Induction of CYP1A1 by serum independent of AhR pathway .
11324719	0	CYP1A1	46,52	AhR	88,91	CYP1A1	AhR	1543	196	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|HepG2 HepG2|nmod|pathway pathway|compound|END_ENTITY	Serum induces a transcriptional activation of CYP1A1 gene in HepG2 independently of the AhR pathway .
11698344	0	CYP1A1	102,108	AhR	50,53	CYP1A1	AhR	1543	196	Gene	Gene	inducibility|compound|START_ENTITY relationship|nmod|inducibility Polymorphisms|dep|relationship Polymorphisms|nmod|gene gene|compound|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|appos|END_ENTITY	Polymorphisms of human aryl_hydrocarbon_receptor -LRB- AhR -RRB- gene in a French population : relationship with CYP1A1 inducibility and lung_cancer .
15667830	0	CYP1A1	13,19	AhR	183,186	CYP1A1	AhR	13076(Tax:10090)	11622(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|role role|nmod|END_ENTITY	Induction of CYP1A1 and CYP1B1 in liver and lung by benzo -LRB- a -RRB- pyrene and 7,12-d _ imethylbenz -LRB- a -RRB- anthracene do not affect distribution of polycyclic_hydrocarbons to target tissue : role of AhR and CYP1B1 in bone marrow_cytotoxicity .
16985033	0	CYP1A1	37,43	AhR	32,35	CYP1A1	AhR	1543	196	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association of polymorphisms in AhR , CYP1A1 , GSTM1 , and GSTT1 genes with levels of DNA damage in peripheral blood lymphocytes among coke-oven workers .
19022236	0	CYP1A1	64,70	AhR	50,53	CYP1A1	AhR	1543	196	Gene	Gene	aryl_hydrocarbon_receptor|dep|START_ENTITY aryl_hydrocarbon_receptor|appos|END_ENTITY	Dexamethasone controls aryl_hydrocarbon_receptor -LRB- AhR -RRB- - mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes .
20187624	0	CYP1A1	39,45	AhR	68,71	CYP1A1	AhR	1543	196	Gene	Gene	induce|dobj|START_ENTITY induce|nmod|END_ENTITY	3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms , respectively .
21342125	0	CYP1A1	44,50	AhR	83,86	CYP1A1	AhR	1543	196	Gene	Gene	enzyme|appos|START_ENTITY enzyme|appos|END_ENTITY	The function of cytochrome_P450_1A1 enzyme -LRB- CYP1A1 -RRB- and aryl_hydrocarbon_receptor -LRB- AhR -RRB- in the placenta .
21963808	0	CYP1A1	100,106	AhR	10,13	CYP1A1	AhR	13076(Tax:10090)	11622(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY caused|dobj|induction caused|nsubj|sites sites|amod|END_ENTITY	Different AhR binding sites of diterpenoid ligands from Andrographis paniculata caused differential CYP1A1 induction in primary culture in mouse hepatocytes .
24120730	0	CYP1A1	62,68	AhR	40,43	CYP1A1	AhR	1543	196	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Effects of artificial sweeteners on the AhR - and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells .
9022676	0	CYP1A1	173,179	AhR	41,44	CYP1A1	AhR	100328613(Tax:9986)	100008995(Tax:9986)	Gene	Gene	inducers|appos|START_ENTITY non-responsive|nmod|inducers known|xcomp|non-responsive Expression|acl|known Expression|nmod|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- Arnt -RRB- in adult rabbits known to be non-responsive to cytochrome_P-450_1A1 -LRB- CYP1A1 -RRB- inducers .
9022676	0	CYP1A1	173,179	Arnt	98,102	CYP1A1	Arnt	100328613(Tax:9986)	100008996(Tax:9986)	Gene	Gene	inducers|appos|START_ENTITY non-responsive|nmod|inducers known|xcomp|non-responsive Expression|acl|known Expression|nmod|aryl_hydrocarbon_receptor aryl_hydrocarbon_receptor|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- and aryl_hydrocarbon_receptor nuclear translocator -LRB- Arnt -RRB- in adult rabbits known to be non-responsive to cytochrome_P-450_1A1 -LRB- CYP1A1 -RRB- inducers .
15047159	0	CYP1A1	45,51	BP8	81,84	CYP1A1	BP8	24296(Tax:10116)	326404(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells .
11166912	0	CYP1A1	31,37	CYP1A2	0,6	CYP1A1	CYP1A2	1543	1544	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CYP1A2 is expressed along with CYP1A1 in the human lung .
11485833	0	CYP1A1	31,37	CYP1A2	0,6	CYP1A1	CYP1A2	1543	1544	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CYP1A2 is expressed along with CYP1A1 in the human lung .
11901090	0	CYP1A1	112,118	CYP1A2	120,126	CYP1A1	CYP1A2	1543	1544	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1 , CYP1A2 , and CYP1B1 .
19424794	4	CYP1A1	742,748	CYP1A2	750,756	UGT1A1	UGT1A6	54658	54578	Gene	Gene	CYP3A7|compound|START_ENTITY CYP3A7|appos|END_ENTITY	Twenty-eight polymorphisms in eight genes of phase I -LRB- CYP1A1 , CYP1A2 , CYP1B1 , CYP2C9 , CYP2C19 , CYP3A4 , CYP3A5 , CYP3A7 -RRB- and nine genes of phase II enzymes -LRB- COMT , GSTM1 , GSTM3 , GSTP1 , GSTT1 , SULT1A1 , UGT1A1 , UGT1A6 , UGT2B7 -RRB- were genotyped .
15566942	7	CYP1A1	1455,1461	CYP1B1	1463,1469	CYP1B1	UGT1A6	1545	54578	Gene	Gene	UGT1A6|compound|START_ENTITY UGT1A6|appos|END_ENTITY	The mixture of PAH also induced CYP1A1 , CYP1B1 , UGT1A6 , and UGT1A7 mRNA expression .
16377763	0	CYP1A1	50,56	CYP1B1	84,90	CYP1A1	CYP1B1	13076(Tax:10090)	13078(Tax:10090)	Gene	Gene	important|nsubj|START_ENTITY important|nmod|detoxication detoxication|appos|metabolism metabolism|nummod|END_ENTITY	Oral benzo -LSB- a -RSB- pyrene in Cyp1 knockout mouse lines : CYP1A1 important in detoxication , CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate .
17980933	0	CYP1A1	8,14	CYP1B1	0,6	CYP1A1	CYP1B1	1543	1545	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|advmod|END_ENTITY	CYP1B1 , CYP1A1 , MPO , and GSTP1 polymorphisms and lung_cancer risk in never-smoking Korean women .
19424794	4	CYP1A1	742,748	CYP1B1	758,764	UGT1A1	UGT2B7	54658	7364	Gene	Gene	CYP3A7|compound|START_ENTITY CYP3A7|appos|END_ENTITY	Twenty-eight polymorphisms in eight genes of phase I -LRB- CYP1A1 , CYP1A2 , CYP1B1 , CYP2C9 , CYP2C19 , CYP3A4 , CYP3A5 , CYP3A7 -RRB- and nine genes of phase II enzymes -LRB- COMT , GSTM1 , GSTM3 , GSTP1 , GSTT1 , SULT1A1 , UGT1A1 , UGT1A6 , UGT2B7 -RRB- were genotyped .
24084344	0	CYP1A1	110,116	CYP1B1	118,124	CYP1A1	CYP1B1	1543	1545	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
24528081	0	CYP1A1	26,32	CYP1B1	38,44	CYP1A1	CYP1B1	1543	1545	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Preferential induction of CYP1A1 over CYP1B1 in human breast_cancer MCF-7 cells after exposure to berberine .
26123186	0	CYP1A1	70,76	CYP1B1	85,91	CYP1A1	CYP1B1	1543	1545	Gene	Gene	START_ENTITY|appos|-RRB- -RRB-|dep|-LRB- -LRB-|compound|END_ENTITY	Differences in 4-hydroxyestradiol levels in leukocytes are related to CYP1A1 -LRB- -RRB- 2C , CYP1B1 -LRB- -RRB- 3 and COMT Val158Met allelic variants .
26123186	0	CYP1A1	70,76	CYP1B1	85,91	CYP1A1	CYP1B1	1543	1545	Gene	Gene	START_ENTITY|appos|-RRB- -RRB-|dep|-LRB- -LRB-|compound|END_ENTITY	Differences in 4-hydroxyestradiol levels in leukocytes are related to CYP1A1 -LRB- -RRB- 2C , CYP1B1 -LRB- -RRB- 3 and COMT Val158Met allelic variants .
9144388	0	CYP1A1	81,87	CYP1B1	73,79	CYP1A1	CYP1B1	24296(Tax:10116)	25426(Tax:10116)	Gene	Gene	TCDD-induced|nummod|START_ENTITY TCDD-induced|nummod|END_ENTITY	Differential time-course and dose-response relationships of TCDD-induced CYP1B1 , CYP1A1 , and CYP1A2 proteins in rats .
12879168	0	CYP1A1	68,74	CYP2C19	51,58	CYP1A1	CYP2C19	1543	1557	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP1A1	30,36	CYP2C19	46,53	CYP1A1	CYP2C19	1543	1557	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12879168	0	CYP1A1	68,74	CYP2C9	43,49	CYP1A1	CYP2C9	1543	1559	Gene	Gene	and|appos|START_ENTITY and|compound|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP1A1	30,36	CYP2C9	38,44	CYP1A1	CYP2C9	1543	1559	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21907728	0	CYP1A1	33,39	CYP2C9	49,55	CYP1A1	CYP2C9	1543	1559	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	Role of genetic polymorphisms of CYP1A1 , CYP3A5 , CYP2C9 , CYP2D6 , and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides .
10022746	0	CYP1A1	40,46	CYP2D6	32,38	CYP1A1	CYP2D6	1543	1565	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Polymorphism in cytochrome P450 CYP2D6 , CYP1A1 , CYP2E1 and glutathione_S-transferase , GSTM1 , GSTM3 , GSTT1 and susceptibility to tobacco-related cancers : studies in upper aerodigestive tract cancers .
10029576	0	CYP1A1	71,77	CYP2D6	79,85	CYP1A1	CYP2D6	1543	1565	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Susceptibility to childhood acute_lymphoblastic_leukemia : influence of CYP1A1 , CYP2D6 , GSTM1 , and GSTT1 genetic polymorphisms .
12879168	0	CYP1A1	68,74	CYP2D6	60,66	CYP1A1	CYP2D6	1543	1565	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
16493615	0	CYP1A1	16,22	CYP2D6	8,14	CYP1A1	CYP2D6	1543	1565	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Role of CYP2D6 , CYP1A1 , CYP2E1 , GSTT1 , and GSTM1 genes in the susceptibility to acute_leukemias .
17479406	0	CYP1A1	25,31	CYP2D6	33,39	CYP1A1	CYP2D6	1543	1565	Gene	Gene	UGT1A7|compound|START_ENTITY UGT1A7|appos|END_ENTITY	Genetic polymorphisms in CYP1A1 , CYP2D6 , UGT1A6 , UGT1A7 , and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population .
20373852	0	CYP1A1	30,36	CYP2D6	55,61	CYP1A1	CYP2D6	1543	1565	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
10022746	0	CYP1A1	40,46	CYP2E1	48,54	CYP1A1	CYP2E1	1543	1571	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Polymorphism in cytochrome P450 CYP2D6 , CYP1A1 , CYP2E1 and glutathione_S-transferase , GSTM1 , GSTM3 , GSTT1 and susceptibility to tobacco-related cancers : studies in upper aerodigestive tract cancers .
16493615	0	CYP1A1	16,22	CYP2E1	24,30	CYP1A1	CYP2E1	1543	1571	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Role of CYP2D6 , CYP1A1 , CYP2E1 , GSTT1 , and GSTM1 genes in the susceptibility to acute_leukemias .
21907728	0	CYP1A1	33,39	CYP3A5	41,47	CYP1A1	CYP3A5	1543	1577	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	Role of genetic polymorphisms of CYP1A1 , CYP3A5 , CYP2C9 , CYP2D6 , and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides .
19682433	0	CYP1A1	67,73	Constitutive_androstane_receptor	0,32	CYP1A1	Constitutive androstane receptor	1543	9970	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Constitutive_androstane_receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5 ' - flanking region .
22294106	0	CYP1A1	21,27	Cytochrome_P450_1A1	0,19	CYP1A1	Cytochrome P450 1A1	1543	1543	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- gene polymorphisms and cervical_cancer risk : a meta-analysis .
22733497	0	CYP1A1	21,27	Cytochrome_P450_1A1	0,19	CYP1A1	Cytochrome P450 1A1	1543	1543	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- gene polymorphisms and ovarian_cancer risk : a meta-analysis .
25048966	0	CYP1A1	21,27	Cytochrome_P450_1A1	0,19	CYP1A1	Cytochrome P450 1A1	1543	1543	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- polymorphism and susceptibility to esophageal_cancer : an updated meta-analysis of 27 studies .
24084344	0	CYP1A1	110,116	EPHX1	126,131	CYP1A1	EPHX1	1543	2052	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
16010691	0	CYP1A1	90,96	Estrogen_receptor_alpha	0,23	CYP1A1	Estrogen receptor alpha	1543	2099	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Estrogen_receptor_alpha increases basal and cigarette_smoke_extract-induced expression of CYP1A1 and CYP1B1 , but not GSTP1 , in normal human bronchial epithelial cells .
11833070	0	CYP1A1	32,38	GSTM1	39,44	CYP1A1	GSTM1	1543	2944	Gene	Gene	Relationship|nmod|START_ENTITY END_ENTITY|nsubj|Relationship	Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal_cancer in Xi'an .
15064998	0	CYP1A1	73,79	GSTM1	89,94	CYP1A1	GSTM1	1543	2944	Gene	Gene	START_ENTITY|appos|CYP2E1 CYP2E1|nummod|END_ENTITY	Relationship between genetic polymorphisms of drug-metabolizing enzymes -LRB- CYP1A1 , CYP2E1 , GSTM1 , and NAT2 -RRB- , drinking habits , histological subtypes , and p53 gene point mutations in Japanese patients with gastric_cancer .
15298956	0	CYP1A1	108,114	GSTM1	116,121	CYP1A1	GSTM1	1543	2944	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Benzo -LRB- a -RRB- pyrene_diolepoxide -LRB- BPDE -RRB- - DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1 , GSTM1 , GSTP1 , GSTT1 , and mEH .
16466991	0	CYP1A1	17,23	GSTM1	25,30	CYP1A1	GSTM1	1543	2944	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|dep|END_ENTITY	Polymorphisms of CYP1A1 , GSTM1 , GSTT1 , and prostate_cancer risk in Turkish population .
16582078	0	CYP1A1	82,88	GSTM1	40,45	CYP1A1	GSTM1	1543	2944	Gene	Gene	glutathione-S-transferase|appos|START_ENTITY glutathione-S-transferase|appos|END_ENTITY	Influence of glutathione-S-transferase -LRB- GSTM1 , GSTP1 , GSTT1 -RRB- and cytochrome p450 -LRB- CYP1A1 , CYP2D6 -RRB- polymorphisms on numbers of basal_cell_carcinomas -LRB- BCCs -RRB- in families with the naevoid_basal_cell_carcinoma_syndrome .
20373852	0	CYP1A1	30,36	GSTM1	70,75	CYP1A1	GSTM1	1543	2944	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21211368	0	CYP1A1	1,7	GSTM1	61,66	CYP1A1	GSTM1	1543	2944	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|appos|lack lack|appos|END_ENTITY	-LSB- CYP1A1 polymorphisms , lack of glutathione_S-transferase M1 -LRB- GSTM1 -RRB- , cooking oil fumes and lung_cancer risk in non-smoking women -RSB- .
24084344	0	CYP1A1	110,116	GSTM1	133,138	CYP1A1	GSTM1	1543	2944	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
15298956	0	CYP1A1	108,114	GSTP1	123,128	CYP1A1	GSTP1	1543	2950	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Benzo -LRB- a -RRB- pyrene_diolepoxide -LRB- BPDE -RRB- - DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1 , GSTM1 , GSTP1 , GSTT1 , and mEH .
16582078	0	CYP1A1	82,88	GSTP1	47,52	CYP1A1	GSTP1	1543	2950	Gene	Gene	glutathione-S-transferase|appos|START_ENTITY glutathione-S-transferase|appos|GSTM1 GSTM1|dep|END_ENTITY	Influence of glutathione-S-transferase -LRB- GSTM1 , GSTP1 , GSTT1 -RRB- and cytochrome p450 -LRB- CYP1A1 , CYP2D6 -RRB- polymorphisms on numbers of basal_cell_carcinomas -LRB- BCCs -RRB- in families with the naevoid_basal_cell_carcinoma_syndrome .
18992797	0	CYP1A1	115,121	GSTP1	169,174	CYP1A1	GSTP1	1543	2950	Gene	Gene	express|dobj|START_ENTITY modified|xcomp|express cells|acl|modified Cytotoxicity|nmod|cells Cytotoxicity|nmod|presence presence|nmod|coexpression coexpression|compound|END_ENTITY	Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1 , in the presence or absence of human GSTP1 coexpression .
22918668	0	CYP1A1	53,59	GSTP1	61,66	CYP1A1	GSTP1	1543	2950	Gene	Gene	START_ENTITY|dep|GSTT1 GSTT1|compound|END_ENTITY	Expression patterns of carcinogen detoxifying genes -LRB- CYP1A1 , GSTP1 _ GSTT1 -RRB- in HNC patients .
20373852	0	CYP1A1	30,36	GSTT1	63,68	CYP1A1	GSTT1	1543	2952	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
23041609	0	CYP1A1	56,62	Liver_X_receptor_a	0,18	CYP1A1	Liver X receptor a	1543	10062	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	Liver_X_receptor_a bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes .
20373852	0	CYP1A1	30,36	MTHFR	77,82	CYP1A1	MTHFR	1543	4524	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP1A1	30,36	MTRR	84,88	CYP1A1	MTRR	1543	4552	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12879168	0	CYP1A1	68,74	NAT2	76,80	CYP1A1	NAT2	1543	10	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP1A1	30,36	NAT2	96,100	CYP1A1	NAT2	1543	10	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP1A1	30,36	NQO1	90,94	CYP1A1	NQO1	1543	1728	Gene	Gene	HLA-DQA1|compound|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
15521013	0	CYP1A1	25,31	PPAR-alpha	61,71	CYP1A1	PPAR-alpha	1543	5465	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites .
14639127	0	CYP1A1	0,6	SCC	39,42	CYP1A1	SCC	1543	6317	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|END_ENTITY	CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx .
22442665	0	CYP1A1	52,58	TLR2	0,4	CYP1A1	TLR2	13076(Tax:10090)	24088(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	TLR2 controls intestinal carcinogen detoxication by CYP1A1 .
17479406	0	CYP1A1	25,31	UGT1A6	41,47	CYP1A1	UGT1A6	1543	54578	Gene	Gene	UGT1A7|compound|START_ENTITY UGT1A7|appos|END_ENTITY	Genetic polymorphisms in CYP1A1 , CYP2D6 , UGT1A6 , UGT1A7 , and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population .
9731718	0	CYP1A1	25,31	aryl_hydrocarbon_hydroxylase	32,60	CYP1A1	aryl hydrocarbon hydroxylase	1543	1543	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|nsubj|relationship	The relationship between CYP1A1 aryl_hydrocarbon_hydroxylase activity and lung_cancer in a Japanese population .
11959854	0	CYP1A1	29,35	aryl_hydrocarbon_receptor	73,98	CYP1A1	aryl hydrocarbon receptor	1543	196	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nsubj|induction	Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl_hydrocarbon_receptor - and calcium-dependent .
15072980	0	CYP1A1	58,64	cytochrome_P4501A1	38,56	CYP1A1	cytochrome P4501A1	24296(Tax:10116)	24296(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Respirable coal_dust particles modify cytochrome_P4501A1 -LRB- CYP1A1 -RRB- expression in rat alveolar cells .
8202380	0	CYP1A1	149,155	cytochrome_P4501A1	129,147	CYP1A1	cytochrome P4501A1	1543	1543	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aryl_hydrocarbon-induced interactions at multiple DNA elements of diverse sequence -- a multicomponent mechanism for activation of cytochrome_P4501A1 -LRB- CYP1A1 -RRB- gene transcription .
9874250	0	CYP1A1	53,59	cytochrome_P4501A1	33,51	CYP1A1	cytochrome P4501A1	1543	1543	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional analysis of the human cytochrome_P4501A1 -LRB- CYP1A1 -RRB- gene enhancer .
20035380	0	CYP1A1	43,49	cytochrome_P450_1A1	22,41	CYP1A1	cytochrome P450 1A1	1543	1543	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Four polymorphisms in cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- gene and breast_cancer risk : a meta-analysis .
2766930	0	CYP1A1	49,55	cytochrome_P450c	31,47	CYP1A1	cytochrome P450c	24296(Tax:10116)	24296(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Transient superinducibility of cytochrome_P450c -LRB- CYP1A1 -RRB- mRNA and transcription .
17466352	0	CYP1A2	86,92	AHR	58,61	CYP1A2	AHR	13077(Tax:10090)	11622(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|uroporphyria uroporphyria|nmod|mice mice|compound|END_ENTITY	Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2 .
21490707	0	CYP1A2	70,76	AHR	54,57	CYP1A2	AHR	1544	196	Gene	Gene	7p21|appos|START_ENTITY 7p21|appos|END_ENTITY	Genome-wide meta-analysis identifies regions on 7p21 -LRB- AHR -RRB- and 15q24 -LRB- CYP1A2 -RRB- as determinants of habitual caffeine consumption .
16820944	0	CYP1A2	26,32	AhR	65,68	CYP1A2	AhR	24297(Tax:10116)	25690(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway : the central role of proinflammatory cytokines .
19854261	0	CYP1A2	137,143	AhR	84,87	CYP1A2	AhR	1544	196	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Effects of dinuclear_copper -LRB- II -RRB- complexes with 6 - -LRB- benzylamino -RRB- purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes .
17618724	0	CYP1A2	15,21	CAR	54,57	CYP1A2	CAR	13077(Tax:10090)	12355(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Pyrene-induced CYP1A2 and SULT1A1 may be regulated by CAR and not by AhR .
11166912	0	CYP1A2	0,6	CYP1A1	31,37	CYP1A2	CYP1A1	1544	1543	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CYP1A2 is expressed along with CYP1A1 in the human lung .
11485833	0	CYP1A2	0,6	CYP1A1	31,37	CYP1A2	CYP1A1	1544	1543	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	CYP1A2 is expressed along with CYP1A1 in the human lung .
11901090	0	CYP1A2	120,126	CYP1A1	112,118	CYP1A2	CYP1A1	1544	1543	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1 , CYP1A2 , and CYP1B1 .
19424794	4	CYP1A2	750,756	CYP1A1	742,748	UGT1A6	UGT1A1	54578	54658	Gene	Gene	CYP3A7|appos|START_ENTITY CYP3A7|compound|END_ENTITY	Twenty-eight polymorphisms in eight genes of phase I -LRB- CYP1A1 , CYP1A2 , CYP1B1 , CYP2C9 , CYP2C19 , CYP3A4 , CYP3A5 , CYP3A7 -RRB- and nine genes of phase II enzymes -LRB- COMT , GSTM1 , GSTM3 , GSTP1 , GSTT1 , SULT1A1 , UGT1A1 , UGT1A6 , UGT2B7 -RRB- were genotyped .
12445029	0	CYP1A2	18,24	CYP1A2	41,47	CYP1A2	CYP1A2	1544	1544	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of the CYP1A2 * 1F mutation on CYP1A2 inducibility in pregnant women .
12445029	0	CYP1A2	41,47	CYP1A2	18,24	CYP1A2	CYP1A2	1544	1544	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of the CYP1A2 * 1F mutation on CYP1A2 inducibility in pregnant women .
12534642	0	CYP1A2	37,43	CYP1A2	50,56	CYP1A2	CYP1A2	1544	1544	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the cytochrome P450 CYP1A2 gene -LRB- CYP1A2 -RRB- in colorectal_cancer patients and controls : allele frequencies , linkage disequilibrium and influence on caffeine metabolism .
12534642	0	CYP1A2	50,56	CYP1A2	37,43	CYP1A2	CYP1A2	1544	1544	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the cytochrome P450 CYP1A2 gene -LRB- CYP1A2 -RRB- in colorectal_cancer patients and controls : allele frequencies , linkage disequilibrium and influence on caffeine metabolism .
10873607	0	CYP1A2	39,45	CYP2C19	77,84	CYP1A2	CYP2C19	1544	1557	Gene	Gene	1A1|nummod|START_ENTITY 1A1|nmod|END_ENTITY	Induction of cytochrome_P450 _ -LRB- CYP -RRB- 1A1 , CYP1A2 , and CYP3A4 but not of CYP2C9 , CYP2C19 , multidrug resistance -LRB- MDR-1 -RRB- and multidrug_resistance_associated_protein -LRB- MRP-1 -RRB- by prototypical inducers in human hepatocytes .
11061577	0	CYP1A2	34,40	CYP2C19	42,49	CYP1A2	CYP2C19	1544	1557	Gene	Gene	N-acetyltransferase-2|compound|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11851639	0	CYP1A2	65,71	CYP2C19	73,80	CYP1A2	CYP2C19	1544	1557	Gene	Gene	CYP2E1|compound|START_ENTITY CYP2E1|appos|END_ENTITY	Effect of chronic disulfiram administration on the activities of CYP1A2 , CYP2C19 , CYP2D6 , CYP2E1 , and N-acetyltransferase in healthy human subjects .
12230892	0	CYP1A2	74,80	CYP2C19	90,97	CYP1A2	CYP2C19	1544	1557	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2 , CYP2C9 , CYP2C19 , CYP2D6 , rCYP2D6 , and CYP3A4 in vitro using a single point IC -LRB- 50 -RRB- .
23081704	0	CYP1A2	30,36	CYP2C19	46,53	CYP1A2	CYP2C19	1544	1557	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	The impact of Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive_disorder .
10627170	0	CYP1A2	90,96	CYP2C9	0,6	CYP1A2	CYP2C9	1544	1559	Gene	Gene	inhibitor|compound|START_ENTITY O-deethylase|parataxis|inhibitor O-deethylase|nsubj|END_ENTITY	CYP2C9 is a principal low-affinity phenacetin O-deethylase : fluvoxamine is not a specific CYP1A2 inhibitor .
10873607	0	CYP1A2	39,45	CYP2C9	69,75	CYP1A2	CYP2C9	1544	1559	Gene	Gene	1A1|nummod|START_ENTITY 1A1|nmod|CYP2C19 CYP2C19|compound|END_ENTITY	Induction of cytochrome_P450 _ -LRB- CYP -RRB- 1A1 , CYP1A2 , and CYP3A4 but not of CYP2C9 , CYP2C19 , multidrug resistance -LRB- MDR-1 -RRB- and multidrug_resistance_associated_protein -LRB- MRP-1 -RRB- by prototypical inducers in human hepatocytes .
12230892	0	CYP1A2	74,80	CYP2C9	82,88	CYP1A2	CYP2C9	1544	1559	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2 , CYP2C9 , CYP2C19 , CYP2D6 , rCYP2D6 , and CYP3A4 in vitro using a single point IC -LRB- 50 -RRB- .
23081704	0	CYP1A2	30,36	CYP2C9	38,44	CYP1A2	CYP2C9	1544	1559	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	The impact of Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive_disorder .
26600202	0	CYP1A2	125,131	CYP2C9	133,139	CYP1A2	CYP2C9	1544	1559	Gene	Gene	CYP2C19|compound|START_ENTITY CYP2C19|appos|END_ENTITY	Multiplex Phenotyping for Systems Medicine : A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2 , CYP2C9 , CYP2C19 , and CYP2D6 Activities Using a Cocktail Approach .
11061577	0	CYP1A2	34,40	CYP2D6	51,57	CYP1A2	CYP2D6	1544	1565	Gene	Gene	N-acetyltransferase-2|compound|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11851639	0	CYP1A2	65,71	CYP2D6	82,88	CYP1A2	CYP2E1	1544	1571	Gene	Gene	CYP2E1|compound|START_ENTITY CYP2E1|appos|END_ENTITY	Effect of chronic disulfiram administration on the activities of CYP1A2 , CYP2C19 , CYP2D6 , CYP2E1 , and N-acetyltransferase in healthy human subjects .
18690546	0	CYP1A2	0,6	CYP2D6	8,14	CYP1A2	CYP2D6	1544	1565	Gene	Gene	GSTP1|compound|START_ENTITY GSTP1|appos|END_ENTITY	CYP1A2 , CYP2D6 , GSTM1 , GSTP1 , and GSTT1 gene polymorphisms in patients with bladder_cancer in a Turkish population .
21678521	0	CYP1A2	33,39	CYP2D6	41,47	CYP1A2	CYP2D6	1544	1565	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	The in vitro inhibition of human CYP1A2 , CYP2D6 and CYP3A4 by tetrahydropalmatine , neferine and berberine .
11061577	0	CYP1A2	34,40	CYP3A	59,64	CYP1A2	CYP3A	1544	1576	Gene	Gene	N-acetyltransferase-2|compound|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
20218903	0	CYP1A2	25,31	CYP3A4	33,39	CYP1A2	CYP3A4	1544	1576	Gene	Gene	CYP3A5|compound|START_ENTITY CYP3A5|appos|END_ENTITY	Genetic polymorphisms of CYP1A2 , CYP3A4 , CYP3A5 , pregnane/steroid _ X_receptor and constitutive_androstane_receptor in 207 healthy Spanish volunteers .
11285205	0	CYP1A2	20,26	Cytochrome_P4501A2	0,18	CYP1A2	Cytochrome P4501A2	1544	1544	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Cytochrome_P4501A2 -LRB- CYP1A2 -RRB- activity and lung_cancer risk : a preliminary study among Chinese women in Singapore .
15217501	0	CYP1A2	21,27	Cytochrome_P450_1A2	0,19	CYP1A2	Cytochrome P450 1A2	1544	1544	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity , mammographic density , and oxidative stress : a cross-sectional study .
15217502	0	CYP1A2	21,27	Cytochrome_P450_1A2	0,19	CYP1A2	Cytochrome P450 1A2	1544	1544	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity and risk factors for breast_cancer : a cross-sectional study .
18690546	0	CYP1A2	0,6	GSTM1	16,21	CYP1A2	GSTM1	1544	2944	Gene	Gene	GSTP1|compound|START_ENTITY GSTP1|appos|END_ENTITY	CYP1A2 , CYP2D6 , GSTM1 , GSTP1 , and GSTT1 gene polymorphisms in patients with bladder_cancer in a Turkish population .
14582254	0	CYP1A2	1,7	NAT2	9,13	CYP1A2	NAT2	1544	10	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CYP1A2 , NAT2 , and GSTM1 phenotype/genotype modulate human exposure and various environmental mutagens : our experience -RSB- .
23603339	0	CYP1A2	55,61	androgen_receptor	82,99	CYP1A2	androgen receptor	1544	367	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen_receptor .
9028875	0	CYP1A2	93,99	cytochrome_P4501A2	73,91	CYP1A2	cytochrome P4501A2	1544	1544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of positive and negative regulatory elements of the human cytochrome_P4501A2 -LRB- CYP1A2 -RRB- gene .
8179586	0	CYP1A2	71,77	cytochrome_P450IA2	51,69	CYP1A2	cytochrome P450IA2	24297(Tax:10116)	24297(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ionic lead , a unique metal ion as an inhibitor for cytochrome_P450IA2 -LRB- CYP1A2 -RRB- expression in the rat liver .
10889552	0	CYP1A2	54,60	cytochrome_P450_1A2	33,52	CYP1A2	cytochrome P450 1A2	1544	1544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A functional polymorphism of the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene : association with tardive_dyskinesia in schizophrenia .
11496364	0	CYP1A2	82,88	cytochrome_P450_1A2	61,80	CYP1A2	cytochrome P450 1A2	1544	1544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between a functional polymorphism of the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene and tardive_dyskinesia in schizophrenia .
15564895	0	CYP1A2	85,91	cytochrome_P450_1A2	64,83	CYP1A2	cytochrome P450 1A2	1544	1544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic association analysis of functional polymorphisms in the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene with tardive_dyskinesia in Japanese patients with schizophrenia .
16261361	0	CYP1A2	76,82	cytochrome_P450_1A2	55,74	CYP1A2	cytochrome P450 1A2	1544	1544	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Artemisinin and thiabendazole are potent inhibitors of cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity in humans .
17611010	0	CYP1A2	53,59	cytochrome_P450_1A2	32,51	CYP1A2	cytochrome P450 1A2	1544	1544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphisms of the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene and prolonged_QTc_interval in schizophrenia .
25081684	0	CYP1A2	47,53	cytochrome_P450_1A2	26,45	CYP1A2	cytochrome P450 1A2	1544	1544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Four polymorphisms in the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene and lung_cancer risk : a meta-analysis .
25442272	0	CYP1A2	86,92	cytochrome_P450_1A2	65,84	CYP1A2	cytochrome P450 1A2	1544	1544	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	In vitro effect of important herbal active constituents on human cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity .
16408225	0	CYP1A2	56,62	growth_hormone	18,32	CYP1A2	growth hormone	1544	2688	Gene	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Lack of effect of growth_hormone replacement therapy on CYP1A2 and xanthine oxidase activities in growth_hormone-deficient children .
18059014	0	CYP1B1	27,33	AhR	68,71	CYP1B1	AhR	1545	196	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Constitutive regulation of CYP1B1 by the aryl_hydrocarbon_receptor -LRB- AhR -RRB- in pre-malignant and malignant mammary tissue .
9744540	0	CYP1B1	14,20	Ah_receptor	153,164	CYP1B1	Ah receptor	1545	196	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure : role of the Ah_receptor .
17615053	0	CYP1B1	51,57	CYP11A1	75,82	CYP1B1	CYP11A1	1545	1583	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP1B1	51,57	CYP17A1	84,91	CYP1B1	CYP17A1	1545	1586	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
15566942	7	CYP1B1	1463,1469	CYP1A1	1455,1461	UGT1A6	CYP1B1	54578	1545	Gene	Gene	UGT1A6|appos|START_ENTITY UGT1A6|compound|END_ENTITY	The mixture of PAH also induced CYP1A1 , CYP1B1 , UGT1A6 , and UGT1A7 mRNA expression .
16377763	0	CYP1B1	84,90	CYP1A1	50,56	CYP1B1	CYP1A1	13078(Tax:10090)	13076(Tax:10090)	Gene	Gene	metabolism|nummod|START_ENTITY detoxication|appos|metabolism important|nmod|detoxication important|nsubj|END_ENTITY	Oral benzo -LSB- a -RSB- pyrene in Cyp1 knockout mouse lines : CYP1A1 important in detoxication , CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate .
17980933	0	CYP1B1	0,6	CYP1A1	8,14	CYP1B1	CYP1A1	1545	1543	Gene	Gene	polymorphisms|advmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	CYP1B1 , CYP1A1 , MPO , and GSTP1 polymorphisms and lung_cancer risk in never-smoking Korean women .
19424794	4	CYP1B1	758,764	CYP1A1	742,748	UGT2B7	UGT1A1	7364	54658	Gene	Gene	CYP3A7|appos|START_ENTITY CYP3A7|compound|END_ENTITY	Twenty-eight polymorphisms in eight genes of phase I -LRB- CYP1A1 , CYP1A2 , CYP1B1 , CYP2C9 , CYP2C19 , CYP3A4 , CYP3A5 , CYP3A7 -RRB- and nine genes of phase II enzymes -LRB- COMT , GSTM1 , GSTM3 , GSTP1 , GSTT1 , SULT1A1 , UGT1A1 , UGT1A6 , UGT2B7 -RRB- were genotyped .
24084344	0	CYP1B1	118,124	CYP1A1	110,116	CYP1B1	CYP1A1	1545	1543	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
24528081	0	CYP1B1	38,44	CYP1A1	26,32	CYP1B1	CYP1A1	1545	1543	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Preferential induction of CYP1A1 over CYP1B1 in human breast_cancer MCF-7 cells after exposure to berberine .
26123186	0	CYP1B1	85,91	CYP1A1	70,76	CYP1B1	CYP1A1	1545	1543	Gene	Gene	-LRB-|compound|START_ENTITY -RRB-|dep|-LRB- END_ENTITY|appos|-RRB-	Differences in 4-hydroxyestradiol levels in leukocytes are related to CYP1A1 -LRB- -RRB- 2C , CYP1B1 -LRB- -RRB- 3 and COMT Val158Met allelic variants .
26123186	0	CYP1B1	85,91	CYP1A1	70,76	CYP1B1	CYP1A1	1545	1543	Gene	Gene	-LRB-|compound|START_ENTITY -RRB-|dep|-LRB- END_ENTITY|appos|-RRB-	Differences in 4-hydroxyestradiol levels in leukocytes are related to CYP1A1 -LRB- -RRB- 2C , CYP1B1 -LRB- -RRB- 3 and COMT Val158Met allelic variants .
9144388	0	CYP1B1	73,79	CYP1A1	81,87	CYP1B1	CYP1A1	25426(Tax:10116)	24296(Tax:10116)	Gene	Gene	TCDD-induced|nummod|START_ENTITY TCDD-induced|nummod|END_ENTITY	Differential time-course and dose-response relationships of TCDD-induced CYP1B1 , CYP1A1 , and CYP1A2 proteins in rats .
17615053	0	CYP1B1	51,57	CYP3A4	59,65	CYP1B1	CYP3A4	1545	1576	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP1B1	51,57	CYP3A5	67,73	CYP1B1	CYP3A5	1545	1577	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
11389879	0	CYP1B1	16,22	Cytochrome_P450	0,15	CYP1B1	Cytochrome P450	1545	4051	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Cytochrome_P450 CYP1B1 protein expression : a novel mechanism of anticancer drug resistance .
16922636	0	CYP1B1	71,77	Cytochrome_P450	0,15	CYP1B1	Cytochrome P450	1545	4051	Gene	Gene	considering|dobj|START_ENTITY aspects|acl|considering interactions|dep|aspects interactions|amod|END_ENTITY	Cytochrome_P450 interactions in human cancers : new aspects considering CYP1B1 .
24084344	0	CYP1B1	118,124	EPHX1	126,131	CYP1B1	EPHX1	1545	2052	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
11558822	0	CYP1B1	111,117	GLC3A	104,109	CYP1B1	GLC3A	1545	1545	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Primary congenital_glaucoma : three case reports on novel mutations and combinations of mutations in the GLC3A -LRB- CYP1B1 -RRB- gene .
12567107	0	CYP1B1	144,150	GLC3A	137,142	CYP1B1	GLC3A	1545	1545	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Primary congenital_glaucoma : a novel single-nucleotide deletion and varying phenotypic expression for the 1,546-1 ,555 dup mutation in the GLC3A -LRB- CYP1B1 -RRB- gene in 2 families of different ethnic origin .
24084344	0	CYP1B1	118,124	GSTM1	133,138	CYP1B1	GSTM1	1545	2944	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
25333344	0	CYP1B1	39,45	Interleukin-6	0,13	CYP1B1	Interleukin-6	1545	3569	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal_cancer involves DNA methylation , miR27b and STAT3 .
24631339	0	CYP1B1	15,21	Leptin	0,6	CYP1B1	Leptin	1545	3952	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin induces CYP1B1 expression in MCF-7 cells through ligand-independent activation of the ERa pathway .
23028769	0	CYP1B1	35,41	MYOC	45,49	CYP1B1	MYOC	1545	4653	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|compound|END_ENTITY	Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis .
15122594	0	CYP1B1	19,25	SULT1A1	10,17	CYP1B1	SULT1A1	1545	6817	Gene	Gene	polymorphisms|nummod|START_ENTITY END_ENTITY|appos|polymorphisms	GST , NAT , SULT1A1 , CYP1B1 genetic polymorphisms , interactions with environmental exposures and bladder_cancer risk in a high-risk population .
12870655	0	CYP1B1	93,99	cytochrome_P450	24,39	CYP1B1	cytochrome P450	1545	4051	Gene	Gene	upregulation|nmod|START_ENTITY profiling|dep|upregulation profiling|nmod|genes genes|amod|END_ENTITY	Transcript profiling of cytochrome_P450 genes in HL-60 human leukemic cells : upregulation of CYP1B1 by all-trans-retinoic_acid .
10511040	0	CYP1B1	51,57	cytochrome_P4501B1	31,49	CYP1B1	cytochrome P4501B1	1545	1545	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel truncating mutation of cytochrome_P4501B1 -LRB- CYP1B1 -RRB- gene in primary infantile_glaucoma .
12372064	0	CYP1B1	64,70	cytochrome_P450_1B1	43,62	CYP1B1	cytochrome P450 1B1	1545	1545	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel frameshift founder mutation in the cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- gene is associated with primary congenital_glaucoma in Morocco .
16319821	0	CYP1B1	80,86	cytochrome_P450_1B1	59,78	CYP1B1	cytochrome P450 1B1	1545	1545	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a common coding polymorphism -LRB- N453S -RRB- of the cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- gene with optic disc cupping and visual field alteration in French patients with primary_open-angle_glaucoma .
20054638	0	CYP1B1	44,50	cytochrome_P450_1B1	23,42	CYP1B1	cytochrome P450 1B1	1545	1545	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Three polymorphisms in cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- gene and breast_cancer risk : a meta-analysis .
9525272	0	CYP1B1	51,57	cytochrome_P450_1B1	30,49	CYP1B1	cytochrome P450 1B1	1545	1545	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Induction and localization of cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- protein in the livers of TCDD-treated rats : detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria .
12365037	0	CYP1a1	17,23	GSTM1	33,38	CYP1a1	GSTM1	1543	2944	Gene	Gene	CYP2e1|compound|START_ENTITY CYP2e1|nummod|END_ENTITY	Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians .
12365037	0	CYP1a1	17,23	GSTT1	40,45	CYP1a1	GSTT1	1543	2952	Gene	Gene	CYP2e1|compound|START_ENTITY CYP2e1|nummod|END_ENTITY	Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians .
25424564	0	CYP2	96,100	pregnane_X_receptor	8,27	CYP2	pregnane X receptor	415182(Tax:7955)	565875(Tax:7955)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|receptor receptor|compound|END_ENTITY	Role of pregnane_X_receptor and aryl_hydrocarbon receptor in transcriptional regulation of pxr , CYP2 , and CYP3 genes in developing zebrafish .
2109953	0	CYP21	39,44	21-hydroxylase	18,32	CYP21	21-hydroxylase	403337(Tax:9823)	13079(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The swine steroid 21-hydroxylase gene -LRB- CYP21 -RRB- : cloning and mapping within the swine leucocyte antigen complex .
1346350	0	CYP21	103,108	cytochrome_P-450_21-hydroxylase	70,101	CYP21	cytochrome P-450 21-hydroxylase	1589	1589	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Rapid identification of deoxyribonucleic acid sequence differences in cytochrome_P-450_21-hydroxylase -LRB- CYP21 -RRB- genes with denaturing gradient gel blots .
2249999	0	CYP21	85,90	steroid_21-hydroxylase	56,78	CYP21	steroid 21-hydroxylase	1589	1589	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Determination of functional effects of mutations in the steroid_21-hydroxylase gene -LRB- CYP21 -RRB- using recombinant vaccinia_virus .
14502362	0	CYP21A1P	67,75	CYP21A2	83,90	CYP21A1P	CYP21A2	1590	1589	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Phenotype and genotype correlation of the microconversion from the CYP21A1P to the CYP21A2 gene in congenital_adrenal_hyperplasia .
21762683	0	CYP21A1P	95,103	CYP21A2	58,65	CYP21A1P	CYP21A2	1590	1589	Gene	Gene	converted|nmod|START_ENTITY mutations|acl|converted mutations|nummod|END_ENTITY	High-resolution melting curve -LRB- HRM -RRB- analysis to establish CYP21A2 mutations converted from the CYP21A1P in congenital_adrenal_hyperplasia .
14502362	0	CYP21A2	83,90	CYP21A1P	67,75	CYP21A2	CYP21A1P	1589	1590	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Phenotype and genotype correlation of the microconversion from the CYP21A1P to the CYP21A2 gene in congenital_adrenal_hyperplasia .
21762683	0	CYP21A2	58,65	CYP21A1P	95,103	CYP21A2	CYP21A1P	1589	1590	Gene	Gene	mutations|nummod|START_ENTITY mutations|acl|converted converted|nmod|END_ENTITY	High-resolution melting curve -LRB- HRM -RRB- analysis to establish CYP21A2 mutations converted from the CYP21A1P in congenital_adrenal_hyperplasia .
19272182	0	CYP21A2	64,71	steroid_21-hydroxylase	35,57	CYP21A2	steroid 21-hydroxylase	1589	1589	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel 9-bp insertion detected in steroid_21-hydroxylase gene -LRB- CYP21A2 -RRB- : prediction of its structural and functional implications by computational methods .
23342490	0	CYP21A2	36,43	steroid_21-hydroxylase	8,30	CYP21A2	steroid 21-hydroxylase	1589	1589	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	-LSB- Unique steroid_21-hydroxylase gene CYP21A2 polymorphism in patients with hyperandrogenism signs -RSB- .
25210767	0	CYP21A2	66,73	steroid_21-hydroxylase	37,59	CYP21A2	steroid 21-hydroxylase	1589	1589	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variants of the human steroid_21-hydroxylase gene -LRB- CYP21A2 -RRB- are related to differences in circulating hormone levels .
16171792	0	CYP21B	119,125	Int6	111,115	CYP21B	Int6	1589	3646	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Linkage between I172N mutation , a marker_of_21-hydroxylase_deficiency , and a single nucleotide polymorphism in Int6 of CYP21B gene : a genetic study of Sardinian family .
2162843	0	CYP21B	42,48	P-450C21	50,58	CYP21B	P-450C21	1589	281741(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	cAMP-dependent transcription of the human CYP21B -LRB- P-450C21 -RRB- gene requires a cis-regulatory element distinct from the consensus cAMP-regulatory element .
14765994	0	CYP24	81,86	25-hydroxyvitamin_D3-24-hydroxylase	44,79	CYP24	25-hydroxyvitamin D3-24-hydroxylase	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Calcitonin stimulates expression of the rat 25-hydroxyvitamin_D3-24-hydroxylase -LRB- CYP24 -RRB- promoter in HEK-293 cells expressing calcitonin receptor : identification of signaling pathways .
16691293	0	CYP24	74,79	Steroid_and_xenobiotic_receptor	0,31	CYP24	Steroid and xenobiotic receptor	1591	8856	Gene	Gene	START_ENTITY|nsubj|mediates mediates|compound|END_ENTITY	Steroid_and_xenobiotic_receptor and vitamin_D_receptor crosstalk mediates CYP24 expression and drug-induced_osteomalacia .
12048211	0	CYP24	107,112	cytochrome_P450C24	87,105	CYP24	cytochrome P450C24	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Role of MAP kinases in the 1,25-dihydroxyvitamin _ D3-induced transactivation of the rat cytochrome_P450C24 -LRB- CYP24 -RRB- promoter .
15836435	0	CYP24	112,117	cytochrome_P450C24	92,110	CYP24	cytochrome P450C24	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Molecular action of 1,25-dihydroxyvitamin _ D3 and phorbol_ester on the activation of the rat cytochrome_P450C24 -LRB- CYP24 -RRB- promoter : role of MAP kinase activities and identification of an important transcription factor binding site .
10426559	0	CYP24	171,176	vitamin_D3-24-hydroxylase	144,169	CYP24	vitamin D3-24-hydroxylase	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1 ,25 -LRB- OH -RRB- 2_vitamin_D3 -LRB- Falecalcitriol -RRB- in rat : induction of vitamin_D3-24-hydroxylase -LRB- CYP24 -RRB- responsible for 23S-hydroxylation in target tissues and the drop in serum levels .
9442090	0	CYP26	15,20	P450RAI	6,13	CYP26	P450RAI	13082(Tax:10090)	13082(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Mouse P450RAI -LRB- CYP26 -RRB- expression and retinoic_acid-inducible retinoic_acid metabolism in F9 cells are regulated by retinoic_acid receptor gamma and retinoid_X receptor alpha .
11023996	0	CYP26	14,19	cytochrome_P450RAI	21,39	CYP26	cytochrome P450RAI	13082(Tax:10090)	13082(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Regulation of CYP26 -LRB- cytochrome_P450RAI -RRB- mRNA expression and retinoic_acid metabolism by retinoids and dietary vitamin_A in liver of mice and rats .
9826557	0	CYP26	34,39	cytochrome_P450RAI	14,32	CYP26	cytochrome P450RAI	1592	1592	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cytochrome_P450RAI -LRB- CYP26 -RRB- in human fetal hepatic and cephalic tissues .
11994980	0	CYP26	90,95	retinoic_acid_4-hydroxylase	61,88	CYP26	retinoic acid 4-hydroxylase	1592	1592	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	all-trans-Retinoic_acid-induced expression and regulation of retinoic_acid_4-hydroxylase -LRB- CYP26 -RRB- in human promyelocytic_leukemia .
24819304	0	CYP26A1	126,133	Hepatocyte_nuclear_factor_4a	0,28	CYP26A1	Hepatocyte nuclear factor 4a	1592	3172	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Hepatocyte_nuclear_factor_4a -LRB- HNF4a -RRB- in coordination with retinoic_acid receptors increases all-trans-retinoic_acid-dependent CYP26A1 gene expression in HepG2 human hepatocytes .
15896339	0	CYP26A1	14,21	RAR	46,49	CYP26A1	RAR	1592	5914	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic_leukemia cells .
12101034	0	CYP26B1	39,46	P450RAI-2	48,57	CYP26B1	P450RAI-2	56603	56603	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of cytochrome CYP26B1 -LRB- P450RAI-2 -RRB- in human cephalic tissues .
10519880	0	CYP27	44,49	sterol_27-hydroxylase	16,37	CYP27	sterol 27-hydroxylase	1593	1593	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Mutation of the sterol_27-hydroxylase gene -LRB- CYP27 -RRB- results in truncation of mRNA expressed in leucocytes in a Japanese family with cerebrotendinous_xanthomatosis .
11395030	0	CYP27	68,73	sterol_27-hydroxylase	40,61	CYP27	sterol 27-hydroxylase	1593	1593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the human sterol_27-hydroxylase gene -LRB- CYP27 -RRB- and promoter mapping .
11486904	0	CYP27	116,121	sterol_27-hydroxylase	88,109	CYP27	sterol 27-hydroxylase	1593	1593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol_27-hydroxylase gene -LRB- CYP27 -RRB- .
9790667	0	CYP27	62,67	sterol_27-hydroxylase	34,55	CYP27	sterol 27-hydroxylase	1593	1593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel Arg362Ser mutation in the sterol_27-hydroxylase gene -LRB- CYP27 -RRB- : its effects on pre-mRNA splicing and enzyme activity .
10541881	0	CYP27	41,46	vitamin_D3_25-hydroxylase	14,39	CYP27	vitamin D3 25-hydroxylase	1593	1593	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of vitamin_D3_25-hydroxylase -LRB- CYP27 -RRB- mRNA after induction by vitamin_D3 or UVB radiation in keratinocytes of human skin equivalents -- a preliminary study .
17088262	0	CYP27A1	12,19	PXR	0,3	CYP27A1	PXR	1593	8856	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine .
16549062	0	CYP27A1	54,61	sterol_27-hydroxylase	31,52	CYP27A1	sterol 27-hydroxylase	1593	1593	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of sterol_27-hydroxylase -LRB- CYP27A1 -RRB- in monkey retina .
12386916	0	CYP27B1	73,80	25-hydroxyvitamin_D3_1-alpha-hydroxylase	31,71	CYP27B1	25-hydroxyvitamin D3 1-alpha-hydroxylase	1594	1594	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence variants in the human 25-hydroxyvitamin_D3_1-alpha-hydroxylase -LRB- CYP27B1 -RRB- gene are not associated with prostate_cancer risk .
24019880	0	CYP27B1	17,24	FGF-23	0,6	CYP27B1	FGF-23	13115(Tax:10090)	64654(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues .
11159799	0	CYP2A1	55,61	Epidermal_growth_factor	0,23	CYP2A1	Epidermal growth factor	24894(Tax:10116)	25313(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Epidermal_growth_factor regulation of female-dependent CYP2A1 and CYP2C12 in primary rat hepatocyte culture .
21791872	0	CYP2A13	75,82	CYP2A6	67,73	CYP2A13	CYP2A6	1553	1548	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
21791872	0	CYP2A13	75,82	CYP4B1	84,90	CYP2A13	CYP4B1	1553	1580	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
25667220	0	CYP2A13	24,31	FOXA2	58,63	CYP2A13	FOXA2	1553	3170	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2 , and their genetic interaction is associated with lung_cancer .
21791872	0	CYP2A13	75,82	SULT1A1	92,99	CYP2A13	SULT1A1	1553	6817	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
21051534	0	CYP2A5	21,27	CYP2E1	49,55	CYP2A5	CYP2E1	13087(Tax:10090)	13106(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|dep|role role|nmod|END_ENTITY	Ethanol induction of CYP2A5 : permissive role for CYP2E1 .
18602936	0	CYP2A5	86,92	PGC-1alpha	12,22	CYP2A5	PGC-1alpha	13087(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes .
21791872	0	CYP2A6	67,73	CYP2A13	75,82	CYP2A6	CYP2A13	1548	1553	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
15861044	0	CYP2A6	20,26	CYP2A6	30,36	CYP2A6	CYP2A6	1548	1548	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Ethnic variation in CYP2A6 * 7 , CYP2A6 * 8 and CYP2A6 * 10 as assessed with a novel haplotyping method .
15861044	0	CYP2A6	30,36	CYP2A6	20,26	CYP2A6	CYP2A6	1548	1548	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Ethnic variation in CYP2A6 * 7 , CYP2A6 * 8 and CYP2A6 * 10 as assessed with a novel haplotyping method .
20139165	0	CYP2A6	79,85	CYP2A6	90,96	CYP2A6	CYP2A6	1548	1548	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Functional characterization of cytochrome P450 2A6 allelic variants CYP2A6 * 15 , CYP2A6 * 16 , CYP2A6 * 21 , and CYP2A6 * 22 .
20139165	0	CYP2A6	90,96	CYP2A6	79,85	CYP2A6	CYP2A6	1548	1548	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Functional characterization of cytochrome P450 2A6 allelic variants CYP2A6 * 15 , CYP2A6 * 16 , CYP2A6 * 21 , and CYP2A6 * 22 .
25710939	0	CYP2A6	37,43	CYP2A7	0,6	CYP2A6	CYP2A7	1548	1549	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	CYP2A7 Pseudogene Transcript Affects CYP2A6 Expression in Human Liver by Acting as a Decoy for miR-126 * UNASSIGNED : Human CYP2A6 is responsible for the metabolic activation of tobacco-related nitrosamines , as well as the metabolism of nicotine and some pharmaceutical drugs .
26367500	0	CYP2A6	35,41	CYP2C19	26,33	CYP2A6	CYP2C19	1548	1557	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
26367500	0	CYP2A6	35,41	CYP2D6	10,16	CYP2A6	CYP2D6	1548	1565	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
25764964	0	CYP2A6	54,60	CYP2E1	62,68	CYP2A6	CYP2E1	1548	1571	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Inhibitory effects of cytochrome P450 enzymes CYP1A2 , CYP2A6 , CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots .
26367500	0	CYP2A6	35,41	CYP3A5	18,24	CYP2A6	CYP3A5	1548	1577	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
21791872	0	CYP2A6	67,73	CYP4B1	84,90	CYP2A6	CYP4B1	1548	1580	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
26367500	0	CYP2A6	35,41	SLCO1B1	43,50	CYP2A6	SLCO1B1	1548	10599	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
21791872	0	CYP2A6	67,73	SULT1A1	92,99	CYP2A6	SULT1A1	1548	6817	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
11159795	0	CYP2A6	50,56	cytochrome_P450_2A6	29,48	CYP2A6	cytochrome P450 2A6	1548	1548	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms in the cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- gene : implications for interindividual differences in nicotine metabolism .
20402563	0	CYP2A6	78,84	cytochrome_P450_2A6	57,76	CYP2A6	cytochrome P450 2A6	1548	1548	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	In vitro modulation of naturally occurring flavonoids on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- activity .
9682269	0	CYP2A6	55,61	cytochrome_P450_2A6	34,53	CYP2A6	cytochrome P450 2A6	1548	1548	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new deleted allele in the human cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- gene found in individuals showing poor metabolic capacity to coumarin and -LRB- + -RRB- - cis-3 ,5 - dimethyl-2 - -LRB- 3-pyridyl -RRB- thiazolidin-4-one_hydrochloride -LRB- SM-12502 -RRB- .
25710939	0	CYP2A7	0,6	CYP2A6	37,43	CYP2A7	CYP2A6	1549	1548	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	CYP2A7 Pseudogene Transcript Affects CYP2A6 Expression in Human Liver by Acting as a Decoy for miR-126 * UNASSIGNED : Human CYP2A6 is responsible for the metabolic activation of tobacco-related nitrosamines , as well as the metabolism of nicotine and some pharmaceutical drugs .
11976065	0	CYP2B	67,72	constitutively_active_receptor	30,60	CYP2B	constitutively active receptor	13088(Tax:10090)	12355(Tax:10090)	Gene	Gene	responses|dep|START_ENTITY responses|nmod|END_ENTITY	Species-specific responses of constitutively_active_receptor -LRB- CAR -RRB- - CYP2B coupling : lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost , scup -LRB- Stenotomus chrysops -RRB- .
15617513	0	CYP2B1	84,90	cytochrome_P450_2B1	63,82	CYP2B1	cytochrome P450 2B1	24300(Tax:10116)	24300(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Regulatory sequence responsible for insulin destabilization of cytochrome_P450_2B1 -LRB- CYP2B1 -RRB- mRNA .
25889207	0	CYP2B6	0,6	CYP2B6	10,16	CYP2B6	CYP2B6	1555	1555	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	CYP2B6 * 6 , CYP2B6 * 18 , Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response : population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe .
25889207	0	CYP2B6	10,16	CYP2B6	0,6	CYP2B6	CYP2B6	1555	1555	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	CYP2B6 * 6 , CYP2B6 * 18 , Body weight and sex are predictors of efavirenz pharmacokinetics and treatment response : population pharmacokinetic modeling in an HIV/AIDS and TB cohort in Zimbabwe .
26930610	0	CYP2B6	30,36	Hepatocyte_Nuclear_Factor_3b	51,79	CYP2B6	Hepatocyte Nuclear Factor 3b	1555	3170	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Transcriptional Regulation of CYP2B6 Expression by Hepatocyte_Nuclear_Factor_3b in Human Liver Cells .
16513849	0	CYP2B6	35,41	constitutive_androstane_receptor	62,94	CYP2B6	constitutive androstane receptor	1555	9970	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive_androstane_receptor but not pregnane_X_receptor .
18287571	0	CYP2B6	95,101	cytochrome_P4502B6	75,93	CYP2B6	cytochrome P4502B6	1555	1555	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome_P4502B6 -LRB- CYP2B6 -RRB- activity .
11502872	0	CYP2B6	24,30	pregnane_X_receptor	51,70	CYP2B6	pregnane X receptor	1555	8856	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the human CYP2B6 gene by the nuclear pregnane_X_receptor .
8156914	0	CYP2C	27,32	GH	77,79	CYP2C	GH	29277(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|growth_hormone growth_hormone|appos|END_ENTITY	The sensitivity of hepatic CYP2C gene expression to baseline growth_hormone -LRB- GH -RRB- bioactivity in dwarf rats : effects of GH-binding protein in vivo .
8156914	0	CYP2C	27,32	growth_hormone	61,75	CYP2C	growth hormone	29277(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The sensitivity of hepatic CYP2C gene expression to baseline growth_hormone -LRB- GH -RRB- bioactivity in dwarf rats : effects of GH-binding protein in vivo .
10601272	0	CYP2C12	26,33	STAT5	53,58	CYP2C12	STAT5	25011(Tax:10116)	24918(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Cooperative regulation of CYP2C12 gene expression by STAT5 and liver-specific factors in female rats .
17239351	0	CYP2C12	13,20	STAT5	186,191	CYP2C12	STAT5	25011(Tax:10116)	24918(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY Induction|nmod|expression correlated|nsubj|Induction correlated|advcl|due due|nmod|decrease decrease|nmod|activation activation|compound|END_ENTITY	Induction of CYP2C12 expression in senescent male rats is well correlated to an increase of HNF3beta expression , while the decline of CYP2C11 expression is unlikely due to a decrease of STAT5 activation .
8617372	0	CYP2C18	47,54	cytochrome_P-45OIIC18	24,45	CYP2C18	cytochrome P-45OIIC18	1562	1562	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic analysis of the cytochrome_P-45OIIC18 -LRB- CYP2C18 -RRB- gene and a novel member of the CYP2C subfamily .
12879168	0	CYP2C19	51,58	CYP1A1	68,74	CYP2C19	CYP1A1	1557	1543	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP2C19	46,53	CYP1A1	30,36	CYP2C19	CYP1A1	1557	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
10873607	0	CYP2C19	77,84	CYP1A2	39,45	CYP2C19	CYP1A2	1557	1544	Gene	Gene	1A1|nmod|START_ENTITY 1A1|nummod|END_ENTITY	Induction of cytochrome_P450 _ -LRB- CYP -RRB- 1A1 , CYP1A2 , and CYP3A4 but not of CYP2C9 , CYP2C19 , multidrug resistance -LRB- MDR-1 -RRB- and multidrug_resistance_associated_protein -LRB- MRP-1 -RRB- by prototypical inducers in human hepatocytes .
11061577	0	CYP2C19	42,49	CYP1A2	34,40	CYP2C19	CYP1A2	1557	1544	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|compound|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11851639	0	CYP2C19	73,80	CYP1A2	65,71	CYP2C19	CYP1A2	1557	1544	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|compound|END_ENTITY	Effect of chronic disulfiram administration on the activities of CYP1A2 , CYP2C19 , CYP2D6 , CYP2E1 , and N-acetyltransferase in healthy human subjects .
12230892	0	CYP2C19	90,97	CYP1A2	74,80	CYP2C19	CYP1A2	1557	1544	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2 , CYP2C9 , CYP2C19 , CYP2D6 , rCYP2D6 , and CYP3A4 in vitro using a single point IC -LRB- 50 -RRB- .
23081704	0	CYP2C19	46,53	CYP1A2	30,36	CYP2C19	CYP1A2	1557	1544	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	The impact of Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive_disorder .
26367500	0	CYP2C19	26,33	CYP2A6	35,41	CYP2C19	CYP2A6	1557	1548	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
11329260	0	CYP2C19	24,31	CYP2C9	96,102	CYP2C19	CYP2C9	1557	1559	Gene	Gene	residues|compound|START_ENTITY Identification|nmod|residues Identification|dep|activity activity|nmod|END_ENTITY	Identification of human CYP2C19 residues that confer S-mephenytoin 4 ' - hydroxylation activity to CYP2C9 .
12230892	0	CYP2C19	90,97	CYP2C9	82,88	CYP2C19	CYP2C9	1557	1559	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2 , CYP2C9 , CYP2C19 , CYP2D6 , rCYP2D6 , and CYP3A4 in vitro using a single point IC -LRB- 50 -RRB- .
12879168	0	CYP2C19	51,58	CYP2C9	43,49	CYP2C19	CYP2C9	1557	1559	Gene	Gene	and|appos|START_ENTITY and|compound|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
15486075	0	CYP2C19	148,155	CYP2C9	21,27	CYP2C19	CYP2C9	1557	1559	Gene	Gene	inability|nmod|START_ENTITY rationale|nmod|inability influence|dobj|rationale influence|nsubj|Interactions Interactions|nmod|END_ENTITY	Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity : possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes .
15860655	0	CYP2C19	89,96	CYP2C9	81,87	CYP2C19	CYP3A4	1557	1576	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	Automated screening with confirmation of mechanism-based inactivation of CYP3A4 , CYP2C9 , CYP2C19 , CYP2D6 , and CYP1A2 in pooled human liver microsomes .
16220110	0	CYP2C19	8,15	CYP2C9	0,6	CYP2C19	CYP2C9	1557	1559	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	CYP2C9 , CYP2C19 , ABCB1 -LRB- MDR1 -RRB- genetic polymorphisms and phenytoin metabolism in a Black Beninese population .
19593158	0	CYP2C19	32,39	CYP2C9	24,30	CYP2C19	CYP2C9	1557	1559	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients .
19855097	0	CYP2C19	50,57	CYP2C9	0,6	CYP2C19	CYP2C9	1557	1559	Gene	Gene	linkage|nmod|START_ENTITY affect|nmod|linkage affect|nsubj|polymorphisms polymorphisms|compound|END_ENTITY	CYP2C9 * 1B promoter polymorphisms , in linkage with CYP2C19 * 2 , affect phenytoin autoinduction of clearance and maintenance dose .
19934793	0	CYP2C19	8,15	CYP2C9	38,44	CYP2C19	CYP2C9	1557	1559	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|* *|compound|END_ENTITY	Besides CYP2C19 * 2 , the variant allele CYP2C9 * 3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation .
20373852	0	CYP2C19	46,53	CYP2C9	38,44	CYP2C19	CYP2C9	1557	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21108610	0	CYP2C19	22,29	CYP2C9	12,18	CYP2C19	CYP2C9	1557	1559	Gene	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of CYP2C9 * 2 , CYP2C19 * 2 , and CYP2D6 * 4 polymorphisms in patients with type_2_diabetes_mellitus .
21532277	0	CYP2C19	135,142	CYP2C9	101,107	CYP2C19	CYP2C9	1557	1559	Gene	Gene	cytochrome_P450_2C9|appos|START_ENTITY cytochrome_P450_2C9|appos|END_ENTITY	-LSB- Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome_P450_2C9 -LRB- CYP2C9 -RRB- and cytochrome_P450_2C19 -LRB- CYP2C19 -RRB- and their clinical application in pediatric patients with epilepsy -RSB- .
21985811	0	CYP2C19	26,33	CYP2C9	17,23	CYP2C19	CYP2C9	1557	1559	Gene	Gene	nucleotide|compound|START_ENTITY nucleotide|compound|END_ENTITY	Possible role of CYP2C9 _ CYP2C19 single nucleotide polymorphisms in drug refractory_epilepsy .
22888523	0	CYP2C19	75,82	CYP2C9	67,73	CYP2C19	CYP2C9	1557	1559	Gene	Gene	CYP3A4|nummod|START_ENTITY CYP3A4|nummod|END_ENTITY	Genetic polymorphisms of drug-metabolizing phase I enzymes CYP3A4 , CYP2C9 , CYP2C19 and CYP2D6 in Han , Uighur , Hui and Mongolian Chinese populations .
23081704	0	CYP2C19	46,53	CYP2C9	38,44	CYP2C19	CYP2C9	1557	1559	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	The impact of Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive_disorder .
10460802	0	CYP2C19	12,19	CYP2D6	86,92	CYP2C19	CYP2D6	1557	1565	Gene	Gene	role|nmod|START_ENTITY role|nmod|metabolism metabolism|nmod|bufuralol bufuralol|appos|substrate substrate|nmod|END_ENTITY	The role of CYP2C19 in the metabolism of -LRB- + / - -RRB- _ bufuralol , the prototypic substrate of CYP2D6 .
10774635	0	CYP2C19	97,104	CYP2D6	88,94	CYP2C19	CYP2D6	1557	1565	Gene	Gene	metabolites|amod|START_ENTITY metabolites|nmod|END_ENTITY	Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6 - , CYP2C19 - and CYP3A4/5-phenotyped patients .
11061577	0	CYP2C19	42,49	CYP2D6	51,57	CYP2C19	CYP2D6	1557	1565	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11851639	0	CYP2C19	73,80	CYP2D6	82,88	CYP2C19	CYP2E1	1557	1571	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|appos|END_ENTITY	Effect of chronic disulfiram administration on the activities of CYP1A2 , CYP2C19 , CYP2D6 , CYP2E1 , and N-acetyltransferase in healthy human subjects .
12879168	0	CYP2C19	51,58	CYP2D6	60,66	CYP2C19	CYP2D6	1557	1565	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP2C19	46,53	CYP2D6	55,61	CYP2C19	CYP2D6	1557	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
26367500	0	CYP2C19	26,33	CYP2D6	10,16	CYP2C19	CYP2D6	1557	1565	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
8730982	0	CYP2C19	77,84	CYP2D6	51,57	CYP2C19	CYP2D6	1557	1565	Gene	Gene	debrisoquine|appos|START_ENTITY debrisoquine|dep|END_ENTITY	Lack of effect of chloroquine on the debrisoquine -LRB- CYP2D6 and S-mephenytoin -LRB- CYP2C19 -RRB- hydroxylation phenotypes .
9754989	0	CYP2C19	61,68	CYP2D6	38,44	CYP2C19	CYP2D6	1557	1565	Gene	Gene	debrisoquine|appos|START_ENTITY debrisoquine|appos|END_ENTITY	Genetic polymorphism of debrisoquine -LRB- CYP2D6 -RRB- and proguanil -LRB- CYP2C19 -RRB- in South Pacific Polynesian populations .
11061577	0	CYP2C19	42,49	CYP3A	59,64	CYP2C19	CYP3A	1557	1576	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
15860655	0	CYP2C19	89,96	CYP3A4	73,79	CYP2C19	CYP3A4	1557	1576	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	Automated screening with confirmation of mechanism-based inactivation of CYP3A4 , CYP2C9 , CYP2C19 , CYP2D6 , and CYP1A2 in pooled human liver microsomes .
22771593	0	CYP2C19	28,35	CYP3A5	38,44	CYP2C19	CYP3A5	1557	1577	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Functional polymorphisms in CYP2C19 _ CYP3A5 genes associated with decreased susceptibility for paediatric tuberculosis .
26367500	0	CYP2C19	26,33	CYP3A5	18,24	CYP2C19	CYP3A5	1557	1577	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
20373852	0	CYP2C19	46,53	GSTM1	70,75	CYP2C19	GSTM1	1557	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP2C19	46,53	GSTT1	63,68	CYP2C19	GSTT1	1557	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
16220110	0	CYP2C19	8,15	MDR1	24,28	CYP2C19	MDR1	1557	5243	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	CYP2C9 , CYP2C19 , ABCB1 -LRB- MDR1 -RRB- genetic polymorphisms and phenytoin metabolism in a Black Beninese population .
20373852	0	CYP2C19	46,53	MTHFR	77,82	CYP2C19	MTHFR	1557	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP2C19	46,53	MTRR	84,88	CYP2C19	MTRR	1557	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12879168	0	CYP2C19	51,58	NAT2	76,80	CYP2C19	NAT2	1557	10	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP2C19	46,53	NAT2	96,100	CYP2C19	NAT2	1557	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20941486	0	CYP2C19	14,21	NAT2	0,4	CYP2C19	NAT2	1557	10	Gene	Gene	CYP2C9|nummod|START_ENTITY CYP2C9|nummod|END_ENTITY	NAT2 , CYP2C9 , CYP2C19 , and CYP2E1 genetic polymorphisms in anti-TB drug-induced maculopapular_eruption .
20373852	0	CYP2C19	46,53	NQO1	90,94	CYP2C19	NQO1	1557	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
26367500	0	CYP2C19	26,33	SLCO1B1	43,50	CYP2C19	SLCO1B1	1557	10599	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
9263374	0	CYP2C19	104,111	cytochrome_P4502C19	83,102	CYP2C19	cytochrome P4502C19	1557	1557	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Single-dose pharmacokinetics and pharmacodynamics of oral triazolam in relation to cytochrome_P4502C19 -LRB- CYP2C19 -RRB- activity .
16641871	0	CYP2C19	37,44	cytochrome_P450_2C19	15,35	CYP2C19	cytochrome P450 2C19	1557	1557	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differences in cytochrome_P450_2C19 -LRB- CYP2C19 -RRB- expression in adjacent normal and tumor tissues in Chinese cancer patients .
15933212	0	CYP2C8	6,12	constitutive_androstane_receptor	69,101	CYP2C8	constitutive androstane receptor	1558	9970	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive_androstane_receptor , pregnane_X_receptor , glucocorticoid_receptor , and hepatic_nuclear_factor_4alpha .
16749864	0	CYP2C9	20,26	CAR	54,57	CYP2C9	CAR	1559	9970	Gene	Gene	promoter|compound|START_ENTITY Activation|nmod|promoter Activation|nmod|END_ENTITY	Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver .
12879168	0	CYP2C9	43,49	CYP1A1	68,74	CYP2C9	CYP1A1	1559	1543	Gene	Gene	and|compound|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP2C9	38,44	CYP1A1	30,36	CYP2C9	CYP1A1	1559	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21907728	0	CYP2C9	49,55	CYP1A1	33,39	CYP2C9	CYP1A1	1559	1543	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	Role of genetic polymorphisms of CYP1A1 , CYP3A5 , CYP2C9 , CYP2D6 , and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides .
10627170	0	CYP2C9	0,6	CYP1A2	90,96	CYP2C9	CYP1A2	1559	1544	Gene	Gene	O-deethylase|nsubj|START_ENTITY O-deethylase|parataxis|inhibitor inhibitor|compound|END_ENTITY	CYP2C9 is a principal low-affinity phenacetin O-deethylase : fluvoxamine is not a specific CYP1A2 inhibitor .
10873607	0	CYP2C9	69,75	CYP1A2	39,45	CYP2C9	CYP1A2	1559	1544	Gene	Gene	CYP2C19|compound|START_ENTITY 1A1|nmod|CYP2C19 1A1|nummod|END_ENTITY	Induction of cytochrome_P450 _ -LRB- CYP -RRB- 1A1 , CYP1A2 , and CYP3A4 but not of CYP2C9 , CYP2C19 , multidrug resistance -LRB- MDR-1 -RRB- and multidrug_resistance_associated_protein -LRB- MRP-1 -RRB- by prototypical inducers in human hepatocytes .
12230892	0	CYP2C9	82,88	CYP1A2	74,80	CYP2C9	CYP1A2	1559	1544	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2 , CYP2C9 , CYP2C19 , CYP2D6 , rCYP2D6 , and CYP3A4 in vitro using a single point IC -LRB- 50 -RRB- .
23081704	0	CYP2C9	38,44	CYP1A2	30,36	CYP2C9	CYP1A2	1559	1544	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	The impact of Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive_disorder .
26600202	0	CYP2C9	133,139	CYP1A2	125,131	CYP2C9	CYP1A2	1559	1544	Gene	Gene	CYP2C19|appos|START_ENTITY CYP2C19|compound|END_ENTITY	Multiplex Phenotyping for Systems Medicine : A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2 , CYP2C9 , CYP2C19 , and CYP2D6 Activities Using a Cocktail Approach .
11329260	0	CYP2C9	96,102	CYP2C19	24,31	CYP2C9	CYP2C19	1559	1557	Gene	Gene	activity|nmod|START_ENTITY Identification|dep|activity Identification|nmod|residues residues|compound|END_ENTITY	Identification of human CYP2C19 residues that confer S-mephenytoin 4 ' - hydroxylation activity to CYP2C9 .
12230892	0	CYP2C9	82,88	CYP2C19	90,97	CYP2C9	CYP2C19	1559	1557	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2 , CYP2C9 , CYP2C19 , CYP2D6 , rCYP2D6 , and CYP3A4 in vitro using a single point IC -LRB- 50 -RRB- .
12879168	0	CYP2C9	43,49	CYP2C19	51,58	CYP2C9	CYP2C19	1559	1557	Gene	Gene	and|compound|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
15486075	0	CYP2C9	21,27	CYP2C19	148,155	CYP2C9	CYP2C19	1559	1557	Gene	Gene	Interactions|nmod|START_ENTITY influence|nsubj|Interactions influence|dobj|rationale rationale|nmod|inability inability|nmod|END_ENTITY	Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity : possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes .
15860655	0	CYP2C9	81,87	CYP2C19	89,96	CYP3A4	CYP2C19	1576	1557	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	Automated screening with confirmation of mechanism-based inactivation of CYP3A4 , CYP2C9 , CYP2C19 , CYP2D6 , and CYP1A2 in pooled human liver microsomes .
16220110	0	CYP2C9	0,6	CYP2C19	8,15	CYP2C9	CYP2C19	1559	1557	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	CYP2C9 , CYP2C19 , ABCB1 -LRB- MDR1 -RRB- genetic polymorphisms and phenytoin metabolism in a Black Beninese population .
19593158	0	CYP2C9	24,30	CYP2C19	32,39	CYP2C9	CYP2C19	1559	1557	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients .
19855097	0	CYP2C9	0,6	CYP2C19	50,57	CYP2C9	CYP2C19	1559	1557	Gene	Gene	polymorphisms|compound|START_ENTITY affect|nsubj|polymorphisms affect|nmod|linkage linkage|nmod|END_ENTITY	CYP2C9 * 1B promoter polymorphisms , in linkage with CYP2C19 * 2 , affect phenytoin autoinduction of clearance and maintenance dose .
19934793	0	CYP2C9	38,44	CYP2C19	8,15	CYP2C9	CYP2C19	1559	1557	Gene	Gene	*|compound|START_ENTITY associated|nsubjpass|* associated|nmod|END_ENTITY	Besides CYP2C19 * 2 , the variant allele CYP2C9 * 3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation .
20373852	0	CYP2C9	38,44	CYP2C19	46,53	CYP2C9	CYP2C19	1559	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21108610	0	CYP2C9	12,18	CYP2C19	22,29	CYP2C9	CYP2C19	1559	1557	Gene	Gene	Analysis|nmod|START_ENTITY END_ENTITY|nsubj|Analysis	Analysis of CYP2C9 * 2 , CYP2C19 * 2 , and CYP2D6 * 4 polymorphisms in patients with type_2_diabetes_mellitus .
21532277	0	CYP2C9	101,107	CYP2C19	135,142	CYP2C9	CYP2C19	1559	1557	Gene	Gene	cytochrome_P450_2C9|appos|START_ENTITY cytochrome_P450_2C9|appos|END_ENTITY	-LSB- Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome_P450_2C9 -LRB- CYP2C9 -RRB- and cytochrome_P450_2C19 -LRB- CYP2C19 -RRB- and their clinical application in pediatric patients with epilepsy -RSB- .
21985811	0	CYP2C9	17,23	CYP2C19	26,33	CYP2C9	CYP2C19	1559	1557	Gene	Gene	nucleotide|compound|START_ENTITY nucleotide|compound|END_ENTITY	Possible role of CYP2C9 _ CYP2C19 single nucleotide polymorphisms in drug refractory_epilepsy .
22888523	0	CYP2C9	67,73	CYP2C19	75,82	CYP2C9	CYP2C19	1559	1557	Gene	Gene	CYP3A4|nummod|START_ENTITY CYP3A4|nummod|END_ENTITY	Genetic polymorphisms of drug-metabolizing phase I enzymes CYP3A4 , CYP2C9 , CYP2C19 and CYP2D6 in Han , Uighur , Hui and Mongolian Chinese populations .
23081704	0	CYP2C9	38,44	CYP2C19	46,53	CYP2C9	CYP2C19	1559	1557	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	The impact of Cytochrome P450 CYP1A2 , CYP2C9 , CYP2C19 and CYP2D6 genes on suicide attempt and suicide risk-a European multicentre study on treatment-resistant major depressive_disorder .
15296644	0	CYP2C9	55,61	CYP2C9	65,71	CYP2C9	CYP2C9	1559	1559	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	High-throughput screening assays for the assessment of CYP2C9 * 1 , CYP2C9 * 2 , and CYP2C9 * 3 metabolism using fluorogenic Vivid substrates .
15296644	0	CYP2C9	65,71	CYP2C9	55,61	CYP2C9	CYP2C9	1559	1559	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	High-throughput screening assays for the assessment of CYP2C9 * 1 , CYP2C9 * 2 , and CYP2C9 * 3 metabolism using fluorogenic Vivid substrates .
15764711	0	CYP2C9	33,39	CYP2C9	8,14	CYP2C9	CYP2C9	1559	1559	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of CYP2C9 and its variants -LRB- CYP2C9 * 3 and CYP2C9 * 13 -RRB- in the metabolism of lornoxicam in humans .
15764711	0	CYP2C9	8,14	CYP2C9	33,39	CYP2C9	CYP2C9	1559	1559	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of CYP2C9 and its variants -LRB- CYP2C9 * 3 and CYP2C9 * 13 -RRB- in the metabolism of lornoxicam in humans .
22863573	0	CYP2C9	12,18	CYP2C9	22,28	CYP2C9	CYP2C9	1559	1559	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Analysis of CYP2C9 * 2 , CYP2C9 * 3 and VKORC1 -1639 _ G > A polymorphisms in a population from South-Eastern Europe .
22863573	0	CYP2C9	22,28	CYP2C9	12,18	CYP2C9	CYP2C9	1559	1559	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Analysis of CYP2C9 * 2 , CYP2C9 * 3 and VKORC1 -1639 _ G > A polymorphisms in a population from South-Eastern Europe .
23201087	0	CYP2C9	39,45	CYP2C9	49,55	CYP2C9	CYP2C9	1559	1559	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Effect of different genetics variants : CYP2C9 * 2 , CYP2C9 * 3 of cytochrome P-450 CYP2C9 and 1639G > A of the VKORC1 gene ; On_acenocoumarol requirement in Moroccan patients .
23201087	0	CYP2C9	49,55	CYP2C9	39,45	CYP2C9	CYP2C9	1559	1559	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Effect of different genetics variants : CYP2C9 * 2 , CYP2C9 * 3 of cytochrome P-450 CYP2C9 and 1639G > A of the VKORC1 gene ; On_acenocoumarol requirement in Moroccan patients .
12879168	0	CYP2C9	43,49	CYP2D6	60,66	CYP2C9	CYP2D6	1559	1565	Gene	Gene	and|compound|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
15844442	0	CYP2C9	129,135	CYP2D6	137,143	CYP2C9	CYP2D6	1559	1565	Gene	Gene	CYP3A4|nummod|START_ENTITY CYP3A4|nummod|END_ENTITY	Structure-based methods for the prediction of the dominant P450 enzyme in human drug biotransformation : consideration of CYP3A4 , CYP2C9 , CYP2D6 .
16783563	0	CYP2C9	113,119	CYP2D6	91,97	CYP2C9	CYP2D6	1559	1565	Gene	Gene	debrisoquine|appos|START_ENTITY debrisoquine|appos|END_ENTITY	Amodiaquine , its desethylated metabolite , or both , inhibit the metabolism of debrisoquine -LRB- CYP2D6 -RRB- and losartan -LRB- CYP2C9 -RRB- in vivo .
18551264	0	CYP2C9	10,16	CYP2D6	1,7	CYP2C9	CYP2D6	1559	1565	Gene	Gene	dose|amod|START_ENTITY -|nmod|dose -|compound|END_ENTITY	-LSB- CYP2D6 - , CYP2C9 - and CYP2C19-based dose adjustments : when do they make sense ? -RSB- .
20373852	0	CYP2C9	38,44	CYP2D6	55,61	CYP2C9	CYP2D6	1559	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
22261394	0	CYP2C9	142,148	CYP2D6	150,156	CYP2C9	CYP2D6	1559	1565	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Effects of Radix Astragali and Radix Rehmanniae , the components of an anti-diabetic foot ulcer herbal formula , on metabolism of model CYP1A2 , CYP2C9 , CYP2D6 , CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms .
24098323	0	CYP2C9	90,96	CYP2D6	82,88	CYP2C9	CYP2D6	1559	1565	Gene	Gene	CYP2C19|appos|START_ENTITY CYP2C19|appos|END_ENTITY	A systematically combined genotype and functional combination analysis of CYP2E1 , CYP2D6 , CYP2C9 , CYP2C19 in different geographic areas of mainland China -- a basis for personalized therapy .
20638257	0	CYP2C9	106,112	CYP2E1	114,120	CYP2C9	CYP2E1	1559	1571	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Major tanshinones of Danshen -LRB- Salvia miltiorrhiza -RRB- exhibit different modes of inhibition on human CYP1A2 , CYP2C9 , CYP2E1 and CYP3A4 activities in vitro .
22261394	0	CYP2C9	142,148	CYP2E1	158,164	CYP2C9	CYP2E1	1559	1571	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Effects of Radix Astragali and Radix Rehmanniae , the components of an anti-diabetic foot ulcer herbal formula , on metabolism of model CYP1A2 , CYP2C9 , CYP2D6 , CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms .
24098323	0	CYP2C9	90,96	CYP2E1	74,80	CYP2C9	CYP2E1	1559	1571	Gene	Gene	CYP2C19|appos|START_ENTITY CYP2C19|compound|END_ENTITY	A systematically combined genotype and functional combination analysis of CYP2E1 , CYP2D6 , CYP2C9 , CYP2C19 in different geographic areas of mainland China -- a basis for personalized therapy .
15860655	0	CYP2C9	81,87	CYP3A4	73,79	CYP3A4	CYP3A4	1576	1576	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	Automated screening with confirmation of mechanism-based inactivation of CYP3A4 , CYP2C9 , CYP2C19 , CYP2D6 , and CYP1A2 in pooled human liver microsomes .
14676821	0	CYP2C9	32,38	CYP3A5	40,46	CYP2C9	CYP3A5	1559	1577	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	Warfarin sensitivity related to CYP2C9 , CYP3A5 , ABCB1 -LRB- MDR1 -RRB- and other factors .
21907728	0	CYP2C9	49,55	CYP3A5	41,47	CYP2C9	CYP3A5	1559	1577	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	Role of genetic polymorphisms of CYP1A1 , CYP3A5 , CYP2C9 , CYP2D6 , and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides .
20373852	0	CYP2C9	38,44	GSTM1	70,75	CYP2C9	GSTM1	1559	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP2C9	38,44	GSTT1	63,68	CYP2C9	GSTT1	1559	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
14676821	0	CYP2C9	32,38	MDR1	55,59	CYP2C9	MDR1	1559	5243	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	Warfarin sensitivity related to CYP2C9 , CYP3A5 , ABCB1 -LRB- MDR1 -RRB- and other factors .
16220110	0	CYP2C9	0,6	MDR1	24,28	CYP2C9	MDR1	1559	5243	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	CYP2C9 , CYP2C19 , ABCB1 -LRB- MDR1 -RRB- genetic polymorphisms and phenytoin metabolism in a Black Beninese population .
20373852	0	CYP2C9	38,44	MTHFR	77,82	CYP2C9	MTHFR	1559	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP2C9	38,44	MTRR	84,88	CYP2C9	MTRR	1559	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12879168	0	CYP2C9	43,49	NAT2	76,80	CYP2C9	NAT2	1559	10	Gene	Gene	and|compound|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP2C9	38,44	NAT2	96,100	CYP2C9	NAT2	1559	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP2C9	38,44	NQO1	90,94	CYP2C9	NQO1	1559	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
24842639	0	CYP2C9	0,6	SLCO1B1	8,15	CYP2C9	SLCO1B1	1559	10599	Gene	Gene	polymorphisms|advmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	CYP2C9 , SLCO1B1 , SLCO1B3 , and ABCB11 polymorphisms in patients with bosentan-induced liver_toxicity .
25069408	0	CYP2C9	45,51	VKORC1	55,61	CYP2C9	VKORC1	1559	79001	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Multiplex pyrosequencing method to determine CYP2C9 * 3 , VKORC1 * 2 , and CYP4F2 * 3 polymorphisms simultaneously : its application to a Korean population and comparisons with other ethnic groups .
10773015	0	CYP2C9	58,64	cytochrome_P450_2C9	37,56	CYP2C9	cytochrome P450 2C9	1559	1559	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Major role of human liver microsomal cytochrome_P450_2C9 -LRB- CYP2C9 -RRB- in the oxidative metabolism of celecoxib , a novel cyclooxygenase-II inhibitor .
16882880	0	CYP2C9	30,36	hepatocyte_nuclear_factor_4alpha	60,92	CYP2C9	hepatocyte nuclear factor 4alpha	1559	3172	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of CYP2C9 , CYP1A1 , and CYP1A2 by hepatocyte_nuclear_factor_4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid_receptor_coactivator_1 .
7733969	0	CYP2D16	68,75	cytochrome_P4502D	49,66	CYP2D16	cytochrome P4502D	100169696(Tax:10141)	100169696(Tax:10141)	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and sequencing of a guinea_pig cytochrome_P4502D -LRB- CYP2D16 -RRB- : high level expression in adrenal microsomes .
10022746	0	CYP2D6	32,38	CYP1A1	40,46	CYP2D6	CYP1A1	1565	1543	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Polymorphism in cytochrome P450 CYP2D6 , CYP1A1 , CYP2E1 and glutathione_S-transferase , GSTM1 , GSTM3 , GSTT1 and susceptibility to tobacco-related cancers : studies in upper aerodigestive tract cancers .
10029576	0	CYP2D6	79,85	CYP1A1	71,77	CYP2D6	CYP1A1	1565	1543	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Susceptibility to childhood acute_lymphoblastic_leukemia : influence of CYP1A1 , CYP2D6 , GSTM1 , and GSTT1 genetic polymorphisms .
12879168	0	CYP2D6	60,66	CYP1A1	68,74	CYP2D6	CYP1A1	1565	1543	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
16493615	0	CYP2D6	8,14	CYP1A1	16,22	CYP2D6	CYP1A1	1565	1543	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Role of CYP2D6 , CYP1A1 , CYP2E1 , GSTT1 , and GSTM1 genes in the susceptibility to acute_leukemias .
17479406	0	CYP2D6	33,39	CYP1A1	25,31	CYP2D6	CYP1A1	1565	1543	Gene	Gene	UGT1A7|appos|START_ENTITY UGT1A7|compound|END_ENTITY	Genetic polymorphisms in CYP1A1 , CYP2D6 , UGT1A6 , UGT1A7 , and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population .
20373852	0	CYP2D6	55,61	CYP1A1	30,36	CYP2D6	CYP1A1	1565	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
11061577	0	CYP2D6	51,57	CYP1A2	34,40	CYP2D6	CYP1A2	1565	1544	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|compound|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11851639	0	CYP2D6	82,88	CYP1A2	65,71	CYP2E1	CYP1A2	1571	1544	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|compound|END_ENTITY	Effect of chronic disulfiram administration on the activities of CYP1A2 , CYP2C19 , CYP2D6 , CYP2E1 , and N-acetyltransferase in healthy human subjects .
18690546	0	CYP2D6	8,14	CYP1A2	0,6	CYP2D6	CYP1A2	1565	1544	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|compound|END_ENTITY	CYP1A2 , CYP2D6 , GSTM1 , GSTP1 , and GSTT1 gene polymorphisms in patients with bladder_cancer in a Turkish population .
21678521	0	CYP2D6	41,47	CYP1A2	33,39	CYP2D6	CYP1A2	1565	1544	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	The in vitro inhibition of human CYP1A2 , CYP2D6 and CYP3A4 by tetrahydropalmatine , neferine and berberine .
26367500	0	CYP2D6	10,16	CYP2A6	35,41	CYP2D6	CYP2A6	1565	1548	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
10460802	0	CYP2D6	86,92	CYP2C19	12,19	CYP2D6	CYP2C19	1565	1557	Gene	Gene	substrate|nmod|START_ENTITY bufuralol|appos|substrate metabolism|nmod|bufuralol role|nmod|metabolism role|nmod|END_ENTITY	The role of CYP2C19 in the metabolism of -LRB- + / - -RRB- _ bufuralol , the prototypic substrate of CYP2D6 .
10774635	0	CYP2D6	88,94	CYP2C19	97,104	CYP2D6	CYP2C19	1565	1557	Gene	Gene	metabolites|nmod|START_ENTITY metabolites|amod|END_ENTITY	Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6 - , CYP2C19 - and CYP3A4/5-phenotyped patients .
11061577	0	CYP2D6	51,57	CYP2C19	42,49	CYP2D6	CYP2C19	1565	1557	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11851639	0	CYP2D6	82,88	CYP2C19	73,80	CYP2E1	CYP2C19	1571	1557	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|appos|END_ENTITY	Effect of chronic disulfiram administration on the activities of CYP1A2 , CYP2C19 , CYP2D6 , CYP2E1 , and N-acetyltransferase in healthy human subjects .
12879168	0	CYP2D6	60,66	CYP2C19	51,58	CYP2D6	CYP2C19	1565	1557	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP2D6	55,61	CYP2C19	46,53	CYP2D6	CYP2C19	1565	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
26367500	0	CYP2D6	10,16	CYP2C19	26,33	CYP2D6	CYP2C19	1565	1557	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
8730982	0	CYP2D6	51,57	CYP2C19	77,84	CYP2D6	CYP2C19	1565	1557	Gene	Gene	debrisoquine|dep|START_ENTITY debrisoquine|appos|END_ENTITY	Lack of effect of chloroquine on the debrisoquine -LRB- CYP2D6 and S-mephenytoin -LRB- CYP2C19 -RRB- hydroxylation phenotypes .
9754989	0	CYP2D6	38,44	CYP2C19	61,68	CYP2D6	CYP2C19	1565	1557	Gene	Gene	debrisoquine|appos|START_ENTITY debrisoquine|appos|END_ENTITY	Genetic polymorphism of debrisoquine -LRB- CYP2D6 -RRB- and proguanil -LRB- CYP2C19 -RRB- in South Pacific Polynesian populations .
12879168	0	CYP2D6	60,66	CYP2C9	43,49	CYP2D6	CYP2C9	1565	1559	Gene	Gene	and|appos|START_ENTITY and|compound|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
15844442	0	CYP2D6	137,143	CYP2C9	129,135	CYP2D6	CYP2C9	1565	1559	Gene	Gene	CYP3A4|nummod|START_ENTITY CYP3A4|nummod|END_ENTITY	Structure-based methods for the prediction of the dominant P450 enzyme in human drug biotransformation : consideration of CYP3A4 , CYP2C9 , CYP2D6 .
16783563	0	CYP2D6	91,97	CYP2C9	113,119	CYP2D6	CYP2C9	1565	1559	Gene	Gene	debrisoquine|appos|START_ENTITY debrisoquine|appos|END_ENTITY	Amodiaquine , its desethylated metabolite , or both , inhibit the metabolism of debrisoquine -LRB- CYP2D6 -RRB- and losartan -LRB- CYP2C9 -RRB- in vivo .
18551264	0	CYP2D6	1,7	CYP2C9	10,16	CYP2D6	CYP2C9	1565	1559	Gene	Gene	-|compound|START_ENTITY -|nmod|dose dose|amod|END_ENTITY	-LSB- CYP2D6 - , CYP2C9 - and CYP2C19-based dose adjustments : when do they make sense ? -RSB- .
20373852	0	CYP2D6	55,61	CYP2C9	38,44	CYP2D6	CYP2C9	1565	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
22261394	0	CYP2D6	150,156	CYP2C9	142,148	CYP2D6	CYP2C9	1565	1559	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Effects of Radix Astragali and Radix Rehmanniae , the components of an anti-diabetic foot ulcer herbal formula , on metabolism of model CYP1A2 , CYP2C9 , CYP2D6 , CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms .
24098323	0	CYP2D6	82,88	CYP2C9	90,96	CYP2D6	CYP2C9	1565	1559	Gene	Gene	CYP2C19|appos|START_ENTITY CYP2C19|appos|END_ENTITY	A systematically combined genotype and functional combination analysis of CYP2E1 , CYP2D6 , CYP2C9 , CYP2C19 in different geographic areas of mainland China -- a basis for personalized therapy .
8971426	0	CYP2D6	30,36	CYP2D6	43,49	CYP2D6	CYP2D6	1565	1565	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel mutant variant of the CYP2D6 gene -LRB- CYP2D6 * 17 -RRB- common in a black African population : association with diminished debrisoquine hydroxylase activity .
8971426	0	CYP2D6	43,49	CYP2D6	30,36	CYP2D6	CYP2D6	1565	1565	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel mutant variant of the CYP2D6 gene -LRB- CYP2D6 * 17 -RRB- common in a black African population : association with diminished debrisoquine hydroxylase activity .
10022746	0	CYP2D6	32,38	CYP2E1	48,54	CYP2D6	CYP2E1	1565	1571	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Polymorphism in cytochrome P450 CYP2D6 , CYP1A1 , CYP2E1 and glutathione_S-transferase , GSTM1 , GSTM3 , GSTT1 and susceptibility to tobacco-related cancers : studies in upper aerodigestive tract cancers .
16493615	0	CYP2D6	8,14	CYP2E1	24,30	CYP2D6	CYP2E1	1565	1571	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Role of CYP2D6 , CYP1A1 , CYP2E1 , GSTT1 , and GSTM1 genes in the susceptibility to acute_leukemias .
22261394	0	CYP2D6	150,156	CYP2E1	158,164	CYP2D6	CYP2E1	1565	1571	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Effects of Radix Astragali and Radix Rehmanniae , the components of an anti-diabetic foot ulcer herbal formula , on metabolism of model CYP1A2 , CYP2C9 , CYP2D6 , CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms .
24098323	0	CYP2D6	82,88	CYP2E1	74,80	CYP2D6	CYP2E1	1565	1571	Gene	Gene	CYP2C19|appos|START_ENTITY CYP2C19|compound|END_ENTITY	A systematically combined genotype and functional combination analysis of CYP2E1 , CYP2D6 , CYP2C9 , CYP2C19 in different geographic areas of mainland China -- a basis for personalized therapy .
11061577	0	CYP2D6	51,57	CYP3A	59,64	CYP2D6	CYP3A	1565	1576	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
19946748	0	CYP2D6	0,6	CYP3A5	10,16	CYP2D6	CYP3A5	1565	1577	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	CYP2D6 * 4 , CYP3A5 * 3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people .
22718623	0	CYP2D6	11,17	CYP3A5	22,28	CYP2D6	CYP3A5	1565	1577	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Effects of CYP2D6 * 10 , CYP3A5 * 3 , CYP1A2 * 1F , and ABCB1 C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects .
26367500	0	CYP2D6	10,16	CYP3A5	18,24	CYP2D6	CYP3A5	1565	1577	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
26542054	0	CYP2D6	40,46	Cytochrome_P450_2D6	19,38	CYP2D6	Cytochrome P450 2D6	1565	1565	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of 22 Novel Cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- Variants Found in the Chinese Population on Hemangeol Metabolism In Vitro .
8528268	0	CYP2D6	45,51	D	52,53	CYP2D6	D	1565	1238	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of the poor metabolizer-associated CYP2D6 -LRB- D -RRB- gene deletion allele by long-PCR technology .
16160620	0	CYP2D6	45,51	GSTM1	26,31	CYP2D6	GSTM1	1565	2944	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|compound|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
16582078	0	CYP2D6	90,96	GSTM1	40,45	CYP2D6	GSTM1	1565	2944	Gene	Gene	CYP1A1|dep|START_ENTITY glutathione-S-transferase|appos|CYP1A1 glutathione-S-transferase|appos|END_ENTITY	Influence of glutathione-S-transferase -LRB- GSTM1 , GSTP1 , GSTT1 -RRB- and cytochrome p450 -LRB- CYP1A1 , CYP2D6 -RRB- polymorphisms on numbers of basal_cell_carcinomas -LRB- BCCs -RRB- in families with the naevoid_basal_cell_carcinoma_syndrome .
18690546	0	CYP2D6	8,14	GSTM1	16,21	CYP2D6	GSTM1	1565	2944	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|appos|END_ENTITY	CYP1A2 , CYP2D6 , GSTM1 , GSTP1 , and GSTT1 gene polymorphisms in patients with bladder_cancer in a Turkish population .
20373852	0	CYP2D6	55,61	GSTM1	70,75	CYP2D6	GSTM1	1565	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20851451	0	CYP2D6	24,30	GSTM1	47,52	CYP2D6	GSTM1	1565	2944	Gene	Gene	2|compound|START_ENTITY C|nummod|2 polymorphism|nmod|C _|nsubj|polymorphism _|dobj|T T|nummod|END_ENTITY	Genetic polymorphism of CYP2D6 2 C _ > _ T 2850 , GSTM1 , NQO1 genes and their correlation with biomarkers in manganese miners of Central India .
11448648	0	CYP2D6	206,212	GSTT1	134,139	CYP2D6	GSTT1	1565	2952	Gene	Gene	genotype|compound|START_ENTITY activity|nmod|genotype genotype|dep|activity genotype|compound|END_ENTITY	Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue : O -LRB- 6 -RRB- - methylguanine levels are associated with GSTT1 genotype and O -LRB- 6 -RRB- - alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype .
16160620	0	CYP2D6	45,51	GSTT1	33,38	CYP2D6	GSTT1	1565	2952	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
20373852	0	CYP2D6	55,61	GSTT1	63,68	CYP2D6	GSTT1	1565	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
7671227	0	CYP2D6	137,143	GSTT1	98,103	CYP2D6	GSTT1	1565	2952	Gene	Gene	loci|appos|START_ENTITY loci|amod|glutathione_S-transferase glutathione_S-transferase|dep|END_ENTITY	Susceptibility to astrocytoma and meningioma : influence of allelism at glutathione_S-transferase -LRB- GSTT1 and GSTM1 -RRB- and cytochrome P-450 -LRB- CYP2D6 -RRB- loci .
25681130	0	CYP2D6	68,74	Guanfu_Base_A	0,13	CYP2D6	Guanfu Base A	1565	2673	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|nsubj|END_ENTITY	Guanfu_Base_A , an Antiarrhythmic Alkaloid of Aconitum Coreanum Is A CYP2D6 Inhibitor of Human , Monkey , and Dog Isoforms .
20373852	0	CYP2D6	55,61	MTHFR	77,82	CYP2D6	MTHFR	1565	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP2D6	55,61	MTRR	84,88	CYP2D6	MTRR	1565	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12879168	0	CYP2D6	60,66	NAT2	76,80	CYP2D6	NAT2	1565	10	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	CYP2D6	55,61	NAT2	96,100	CYP2D6	NAT2	1565	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	CYP2D6	55,61	NQO1	90,94	CYP2D6	NQO1	1565	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
16160620	0	CYP2D6	45,51	PgP	40,43	CYP2D6	PgP	1565	283871	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
26367500	0	CYP2D6	10,16	SLCO1B1	43,50	CYP2D6	SLCO1B1	1565	10599	Gene	Gene	ABCB1|compound|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
1389951	0	CYP2D6	78,84	cytochrome_P4502D6	58,76	CYP2D6	cytochrome P4502D6	1565	1565	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effect of selective serotonin re-uptake inhibitors on cytochrome_P4502D6 -LRB- CYP2D6 -RRB- activity in human liver microsomes .
15768052	0	CYP2D6	92,98	cytochrome_P4502D6	72,90	CYP2D6	cytochrome P4502D6	1565	1565	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of novel sequence variations in the cytochrome_P4502D6 -LRB- CYP2D6 -RRB- gene in African Americans .
10807974	0	CYP2D6	25,31	cytochrome_P450_2D6	4,23	CYP2D6	cytochrome P450 2D6	1565	1565	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- gene polymorphism among breast and head_and_neck_cancer patients .
11037801	0	CYP2D6	29,35	cytochrome_P450_2D6	8,27	CYP2D6	cytochrome P450 2D6	1565	1565	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- in the stereospecific metabolism of E - and Z-doxepin .
16192683	0	CYP2D6	38,44	cytochrome_P450_2D6	17,36	CYP2D6	cytochrome P450 2D6	1565	1565	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Determination of cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- gene copy number by real-time quantitative PCR .
16808005	0	CYP2D6	74,80	cytochrome_P450_2D6	53,72	CYP2D6	cytochrome P450 2D6	1565	1565	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism-based inhibition of human liver microsomal cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by alkamides of Piper nigrum .
17270484	0	CYP2D6	136,142	cytochrome_P450_2D6	115,134	CYP2D6	cytochrome P450 2D6	1565	1565	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of catechol-0-methyltransferase -LRB- COMT -RRB- , monoamine_oxidase_B -LRB- MAOB -RRB- , N-acetyltransferase_2 -LRB- NAT2 -RRB- and cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- gene in patients with early onset of Parkinson 's _ disease .
8448065	0	CYP2D6	41,47	cytochrome_P450_2D6	20,39	CYP2D6	cytochrome P450 2D6	1565	1565	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by methadone .
8941025	0	CYP2D6	25,31	cytochrome_P450_2D6	4,23	CYP2D6	cytochrome P450 2D6	1565	1565	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- enzyme polymorphism : screening costs and influence on clinical outcomes in psychiatry .
7901140	0	CYP2D6	56,62	debrisoquine_4-hydroxylase	28,54	CYP2D6	debrisoquine 4-hydroxylase	1565	1565	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	DNA haplotype dependency of debrisoquine_4-hydroxylase -LRB- CYP2D6 -RRB- expression among extensive metabolisers .
20598484	0	CYP2E1	30,36	ALDH2	23,28	CYP2E1	ALDH2	1571	217	Gene	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution of ADH1B , ALDH2 , CYP2E1 * 6 , and CYP2E1 * 7B genotypes in Turkish population .
23023167	0	CYP2E1	67,73	CB1	45,48	CYP2E1	CB1	13106(Tax:10090)	12801(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Estrogen-related receptor y controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver_injury by alcohol .
10022746	0	CYP2E1	48,54	CYP1A1	40,46	CYP2E1	CYP1A1	1571	1543	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Polymorphism in cytochrome P450 CYP2D6 , CYP1A1 , CYP2E1 and glutathione_S-transferase , GSTM1 , GSTM3 , GSTT1 and susceptibility to tobacco-related cancers : studies in upper aerodigestive tract cancers .
16493615	0	CYP2E1	24,30	CYP1A1	16,22	CYP2E1	CYP1A1	1571	1543	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Role of CYP2D6 , CYP1A1 , CYP2E1 , GSTT1 , and GSTM1 genes in the susceptibility to acute_leukemias .
21051534	0	CYP2E1	49,55	CYP2A5	21,27	CYP2E1	CYP2A5	13106(Tax:10090)	13087(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY induction|dep|role induction|nmod|END_ENTITY	Ethanol induction of CYP2A5 : permissive role for CYP2E1 .
25764964	0	CYP2E1	62,68	CYP2A6	54,60	CYP2E1	CYP2A6	1571	1548	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Inhibitory effects of cytochrome P450 enzymes CYP1A2 , CYP2A6 , CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots .
20638257	0	CYP2E1	114,120	CYP2C9	106,112	CYP2E1	CYP2C9	1571	1559	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Major tanshinones of Danshen -LRB- Salvia miltiorrhiza -RRB- exhibit different modes of inhibition on human CYP1A2 , CYP2C9 , CYP2E1 and CYP3A4 activities in vitro .
22261394	0	CYP2E1	158,164	CYP2C9	142,148	CYP2E1	CYP2C9	1571	1559	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Effects of Radix Astragali and Radix Rehmanniae , the components of an anti-diabetic foot ulcer herbal formula , on metabolism of model CYP1A2 , CYP2C9 , CYP2D6 , CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms .
24098323	0	CYP2E1	74,80	CYP2C9	90,96	CYP2E1	CYP2C9	1571	1559	Gene	Gene	CYP2C19|compound|START_ENTITY CYP2C19|appos|END_ENTITY	A systematically combined genotype and functional combination analysis of CYP2E1 , CYP2D6 , CYP2C9 , CYP2C19 in different geographic areas of mainland China -- a basis for personalized therapy .
10022746	0	CYP2E1	48,54	CYP2D6	32,38	CYP2E1	CYP2D6	1571	1565	Gene	Gene	P450|nummod|START_ENTITY P450|nummod|END_ENTITY	Polymorphism in cytochrome P450 CYP2D6 , CYP1A1 , CYP2E1 and glutathione_S-transferase , GSTM1 , GSTM3 , GSTT1 and susceptibility to tobacco-related cancers : studies in upper aerodigestive tract cancers .
16493615	0	CYP2E1	24,30	CYP2D6	8,14	CYP2E1	CYP2D6	1571	1565	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Role of CYP2D6 , CYP1A1 , CYP2E1 , GSTT1 , and GSTM1 genes in the susceptibility to acute_leukemias .
22261394	0	CYP2E1	158,164	CYP2D6	150,156	CYP2E1	CYP2D6	1571	1565	Gene	Gene	CYP1A2|nummod|START_ENTITY CYP1A2|nummod|END_ENTITY	Effects of Radix Astragali and Radix Rehmanniae , the components of an anti-diabetic foot ulcer herbal formula , on metabolism of model CYP1A2 , CYP2C9 , CYP2D6 , CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms .
24098323	0	CYP2E1	74,80	CYP2D6	82,88	CYP2E1	CYP2D6	1571	1565	Gene	Gene	CYP2C19|compound|START_ENTITY CYP2C19|appos|END_ENTITY	A systematically combined genotype and functional combination analysis of CYP2E1 , CYP2D6 , CYP2C9 , CYP2C19 in different geographic areas of mainland China -- a basis for personalized therapy .
12743671	0	CYP2E1	20,26	Cytochrome_P4502E1	0,18	CYP2E1	Cytochrome P4502E1	1571	1571	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cytochrome_P4502E1 -LRB- CYP2E1 -RRB- expression in peripheral blood lymphocytes : evaluation in hepatitis_C and diabetes .
23949201	0	CYP2E1	62,68	EPHX1	70,75	CYP2E1	EPHX1	1571	2052	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Dietary aflatoxin_B1 intake , genetic polymorphisms of CYP1A2 , CYP2E1 , EPHX1 , GSTM1 , and GSTT1 , and gastric_cancer risk in Korean .
11756225	0	CYP2E1	48,54	FANCG	4,9	CYP2E1	FANCG	1571	2189	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	The FANCG Fanconi_anemia protein interacts with CYP2E1 : possible role in protection against oxidative DNA damage .
24500986	0	CYP2E1	0,6	GLUT4	15,20	CYP2E1	GLUT4	25086(Tax:10116)	25139(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	CYP2E1 impairs GLUT4 gene expression and function : NRF2 as a possible mediator .
7710685	0	CYP2E1	81,87	HNF-1_alpha	48,59	CYP2E1	HNF-1 alpha	25086(Tax:10116)	24817(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of the liver-enriched transcription factor HNF-1_alpha in expression of the CYP2E1 gene .
25238230	0	CYP2E1	13,19	HNF4a	55,60	CYP2E1	HNF4a	1571	3172	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	HBx inhibits CYP2E1 gene expression via downregulating HNF4a in human hepatoma cells .
23241420	0	CYP2E1	27,33	HSP90	52,57	CYP2E1	HSP90	13106(Tax:10090)	111058(Tax:10090)	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	The possible mechanisms of CYP2E1 interactions with HSP90 and the influence of ethanol on them .
12460800	0	CYP2E1	40,46	MPO	48,51	CYP2E1	MPO	1571	4353	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association of genetic polymorphisms in CYP2E1 , MPO , NQO1 , GSTM1 , and GSTT1 genes with benzene_poisoning .
12460800	0	CYP2E1	40,46	NQO1	53,57	CYP2E1	NQO1	1571	1728	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association of genetic polymorphisms in CYP2E1 , MPO , NQO1 , GSTM1 , and GSTT1 genes with benzene_poisoning .
24500986	0	CYP2E1	0,6	NRF2	51,55	CYP2E1	NRF2	25086(Tax:10116)	83619(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	CYP2E1 impairs GLUT4 gene expression and function : NRF2 as a possible mediator .
16374848	0	CYP2E1	21,27	Nrf2	0,4	CYP2E1	Nrf2	25086(Tax:10116)	83619(Tax:10116)	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|END_ENTITY	Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1 .
16551616	0	CYP2E1	55,61	Nrf2	21,25	CYP2E1	Nrf2	1571	4780	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic_acid-dependent toxicity .
19671018	0	CYP2E1	37,43	Nrf2	0,4	CYP2E1	Nrf2	13106(Tax:10090)	18024(Tax:10090)	Gene	Gene	defense|nmod|START_ENTITY defense|amod|END_ENTITY	Nrf2 and antioxidant defense against CYP2E1 toxicity .
23400918	0	CYP2E1	37,43	Nrf2	0,4	CYP2E1	Nrf2	25086(Tax:10116)	83619(Tax:10116)	Gene	Gene	defense|nmod|START_ENTITY defense|amod|END_ENTITY	Nrf2 and antioxidant defense against CYP2E1 toxicity .
25227845	0	CYP2E1	39,45	PstI	46,50	CYP2E1	PstI	1571	6690	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Significant genotype difference in the CYP2E1 PstI polymorphism of Indigenous groups in Sabah , Malaysia with Asian and non-Asian populations .
26125714	0	CYP2E1	0,6	PstI	7,11	CYP2E1	PstI	1571	6690	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	CYP2E1 PstI polymorphism increases cervical_neoplasia risk : a meta-analysis .
10490907	0	CYP2E1	34,40	cytochrome_P-450_2E1	12,32	CYP2E1	cytochrome P-450 2E1	1571	1571	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Duration of cytochrome_P-450_2E1 -LRB- CYP2E1 -RRB- inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans .
11939710	0	CYP2E1	53,59	cytochrome_P-450_2E1	31,51	CYP2E1	cytochrome P-450 2E1	25086(Tax:10116)	25086(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of methacrylonitrile on cytochrome_P-450_2E1 -LRB- CYP2E1 -RRB- expression in male F344 rats .
15585372	0	CYP2E1	34,40	cytochrome_P4502E1	14,32	CYP2E1	cytochrome P4502E1	1571	1571	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Comparison of cytochrome_P4502E1 -LRB- CYP2E1 -RRB- activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis_C .
20100563	0	CYP2E1	53,59	cytochrome_P4502E1	33,51	CYP2E1	cytochrome P4502E1	1571	1571	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Genetic polymorphism analysis of cytochrome_P4502E1 -LRB- CYP2E1 -RRB- in Chinese Han populations from four different geographic areas of Mainland China .
7786308	0	CYP2E1	37,43	cytochrome_P4502E1	17,35	CYP2E1	cytochrome P4502E1	25086(Tax:10116)	25086(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Rapid changes in cytochrome_P4502E1 -LRB- CYP2E1 -RRB- activity and other P450 isozymes following ethanol withdrawal in rats .
9538127	0	CYP2E1	47,53	cytochrome_P4502E1	27,45	CYP2E1	cytochrome P4502E1	25086(Tax:10116)	25086(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of cytochrome_P4502E1 -LRB- CYP2E1 -RRB- in Morris_hepatomas and livers of tumor bearing rats .
7915935	0	CYP2E1	54,60	cytochrome_P450IIE1	62,81	CYP2E1	cytochrome P450IIE1	1571	1571	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Restriction fragment length polymorphism of the human CYP2E1 -LRB- cytochrome_P450IIE1 -RRB- gene and susceptibility to lung_cancer : possible relevance to low smoking exposure .
22668639	0	CYP2E1	38,44	cytochrome_P450_2E1	17,36	CYP2E1	cytochrome P450 2E1	13106(Tax:10090)	13106(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of cytochrome_P450_2E1 -LRB- CYP2E1 -RRB- in the development of high fat-induced non-alcoholic_steatohepatitis .
10898951	0	CYP2E1	0,6	hsp90	86,91	CYP2E1	hsp90	1571	3320	Gene	Gene	degradation|compound|START_ENTITY degradation|dep|role role|nmod|END_ENTITY	CYP2E1 degradation by in vitro reconstituted systems : role of the molecular chaperone hsp90 .
11101004	0	CYP2E1	35,41	interleukin_4	50,63	CYP2E1	interleukin 4	1571	3565	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	The induction of the human hepatic CYP2E1 gene by interleukin_4 is transcriptional and regulated by protein kinase C. Cytochrome_P4502E1 -LRB- CYP2E1 -RRB- plays a key role in the metabolism of numerous drug substrates , mostly in mammalian liver .
24408518	0	CYP2E1	33,39	placental_lactogen	6,24	CYP2E1	placental lactogen	1571	1443	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Human placental_lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes .
11562429	0	CYP2H1	50,56	xenobiotic_receptor	111,130	CYP2H1	xenobiotic receptor	414746(Tax:9031)	395439(Tax:9031)	Gene	Gene	induction|nmod|START_ENTITY mediate|dobj|induction mediate|nmod|END_ENTITY	Multiple_enhancer_units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic_receptor .
19823578	0	CYP2J2	17,23	PPARalpha	55,64	CYP2J2	PPARalpha	1573	5465	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo .
2993801	0	CYP3	198,202	CYP1	114,118	CYP3	CYP1	854897(Tax:4932)	850958(Tax:4932)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Regulation of the expression of iso 2-cytochrome c gene in S. _ cerevisiae : cloning of the positive regulatory gene CYP1 and identification of the region of its target sequence on the structural gene CYP3 .
25569847	0	CYP356A1	86,94	cytochrome_P450_isoform_356A1	55,84	CYP356A1	cytochrome P450 isoform 356A1	105348415	105348415	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Expression and immunohistochemical localization of the cytochrome_P450_isoform_356A1 -LRB- CYP356A1 -RRB- in oyster Crassostrea_gigas .
11061577	0	CYP3A	59,64	CYP1A2	34,40	CYP3A	CYP1A2	1576	1544	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|compound|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11061577	0	CYP3A	59,64	CYP2C19	42,49	CYP3A	CYP2C19	1576	1557	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11061577	0	CYP3A	59,64	CYP2D6	51,57	CYP3A	CYP2D6	1576	1565	Gene	Gene	N-acetyltransferase-2|appos|START_ENTITY N-acetyltransferase-2|appos|END_ENTITY	Combined phenotypic assessment of CYP1A2 , CYP2C19 , CYP2D6 , CYP3A , N-acetyltransferase-2 , and xanthine oxidase with the `` Cooperstown cocktail '' .
11717173	0	CYP3A	143,148	Cytochrome_P450	0,15	CYP3A	Cytochrome P450	1576	4051	Gene	Gene	isoforms|compound|START_ENTITY activity|nmod|isoforms Involvement|dep|activity Involvement|compound|END_ENTITY	Cytochrome_P450 Involvement in the biotransformation of cisapride and racemic_norcisapride in vitro : differential activity of individual human CYP3A isoforms .
11336976	0	CYP3A	64,69	Pregnane_X_receptor	0,19	CYP3A	Pregnane X receptor	1576	8856	Gene	Gene	induction|nummod|START_ENTITY differences|nmod|induction basis|nmod|differences END_ENTITY|dep|basis	Pregnane_X_receptor : molecular basis for species differences in CYP3A induction by xenobiotics .
22982774	0	CYP3A	57,62	Pregnane_X_receptor	0,19	CYP3A	Pregnane X receptor	13112(Tax:10090)	18171(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Pregnane_X_receptor mediated-transcription regulation of CYP3A by glycyrrhizin : a possible mechanism for its hepatoprotective property against lithocholic_acid-induced injury .
1643634	0	CYP3A	40,45	cytochrome_P-450	8,24	CYP3A	cytochrome P-450	1576	4051	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Role of cytochrome_P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes .
1630156	0	CYP3A	28,33	cytochrome_P-4503A	8,26	CYP3A	cytochrome P-4503A	1576	1576	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Hepatic cytochrome_P-4503A -LRB- CYP3A -RRB- activity in the elderly .
11454912	0	CYP3A	126,131	cytochrome_P450	87,102	CYP3A	cytochrome P450	1576	4051	Gene	Gene	role|nmod|START_ENTITY metabolism|dep|role metabolism|nmod|interaction interaction|nmod|enzymes enzymes|amod|END_ENTITY	Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome_P450 enzymes : major role of CYP3A .
15159443	0	CYP3A	133,138	cytochrome_P450	80,95	CYP3A	cytochrome P450	1576	4051	Gene	Gene	roles|nmod|START_ENTITY evaluation|dep|roles evaluation|nmod|biotransformation biotransformation|nmod|system system|amod|END_ENTITY	Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome_P450 system in vitro : prominent roles for CYP3A and CYP2D6 .
21890735	0	CYP3A	94,99	cytochrome_P450	54,69	CYP3A	cytochrome P450	1576	4051	Gene	Gene	inhibition|compound|START_ENTITY Proluciferin_acetals|nmod|inhibition Proluciferin_acetals|nmod|activity activity|amod|END_ENTITY	Proluciferin_acetals as bioluminogenic substrates for cytochrome_P450 activity and probes for CYP3A inhibition .
23491640	0	CYP3A	66,71	cytochrome_P450	33,48	CYP3A	cytochrome P450	1576	4051	Gene	Gene	subfamily|compound|START_ENTITY expression|nmod|subfamily expression|nmod|enzymes enzymes|amod|END_ENTITY	Differential expression of human cytochrome_P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls .
9574808	0	CYP3A	69,74	cytochrome_P450	53,68	CYP3A	cytochrome P450	170509(Tax:10116)	25251(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Ethylmorphine N-demethylase activity as a marker for cytochrome_P450 CYP3A activity in rat hepatic microsomes .
19225389	0	CYP3A	65,70	cytochrome_P4503A	46,63	CYP3A	cytochrome P4503A	1576	1576	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Methadone pharmacokinetics are independent of cytochrome_P4503A -LRB- CYP3A -RRB- activity and gastrointestinal drug transport : insights from methadone interactions with ritonavir/indinavir .
19232844	0	CYP3A	102,107	cytochrome_P4503A	83,100	CYP3A	cytochrome P4503A	1576	1576	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome_P4503A -LRB- CYP3A -RRB- activity .
10230766	0	CYP3A	30,35	cytochrome_P450_3A	10,28	CYP3A	cytochrome P450 3A	13112(Tax:10090)	13112(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Unchanged cytochrome_P450_3A -LRB- CYP3A -RRB- expression and metabolism of midazolam , triazolam , and dexamethasone in mdr -LRB- - / - -RRB- mouse liver microsomes .
12951492	0	CYP3A	59,64	cytochrome_P450_3A	39,57	CYP3A	cytochrome P450 3A	1576	1576	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibitory effects of citrus fruits on cytochrome_P450_3A -LRB- CYP3A -RRB- activity in humans .
15342613	0	CYP3A	53,58	cytochrome_P450_3A	33,51	CYP3A	cytochrome P450 3A	1576	1576	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effects of modifying in vivo cytochrome_P450_3A -LRB- CYP3A -RRB- activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity .
11950789	0	CYP3A	13,18	pregnane_X_receptor	76,95	CYP3A	pregnane X receptor	13112(Tax:10090)	18171(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY Induction|nmod|expression Induction|dep|involvement involvement|nmod|END_ENTITY	Induction of CYP3A expression by dehydroepiandrosterone : involvement of the pregnane_X_receptor .
14709622	0	CYP3A	0,5	pregnane_X_receptor	109,128	CYP3A	pregnane X receptor	170509(Tax:10116)	18171(Tax:10090)	Gene	Gene	induction|nummod|START_ENTITY mediated|nsubjpass|induction mediated|nmod|END_ENTITY	CYP3A induction by liver_x_receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane_X_receptor .
15075359	0	CYP3A	63,68	pregnane_X_receptor	97,116	CYP3A	pregnane X receptor	1576	8856	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane_X_receptor .
16547076	0	CYP3A	37,42	pregnane_X_receptor	69,88	CYP3A	pregnane X receptor	1576	8856	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	The mycoestrogen zearalenone induces CYP3A through activation of the pregnane_X_receptor .
20082578	0	CYP3A	157,162	pregnane_X_receptor	75,94	CYP3A	pregnane X receptor	1576	8856	Gene	Gene	metabolism|appos|START_ENTITY variability|nmod|metabolism associated|nmod|variability region|acl|associated region|nmod|gene gene|compound|END_ENTITY	Identification of polymorphisms in the 3 ' - untranslated region of the human pregnane_X_receptor -LRB- PXR -RRB- gene associated with variability in cytochrome_P450_3A -LRB- CYP3A -RRB- metabolism .
21402137	0	CYP3A	77,82	pregnane_X_receptor	100,119	CYP3A	pregnane X receptor	170509(Tax:10116)	84385(Tax:10116)	Gene	Gene	drugs|nmod|START_ENTITY interacts|nmod|drugs interacts|nmod|inhibition inhibition|nmod|activation activation|amod|END_ENTITY	3,4-methylenedioxymethamphetamine -LRB- MDMA -RRB- interacts with therapeutic drugs on CYP3A by inhibition of pregnane_X_receptor -LRB- PXR -RRB- activation and catalytic enzyme inhibition .
24853400	0	CYP3A	14,19	pregnane_X_receptor	74,93	CYP3A	pregnane X receptor	13112(Tax:10090)	18171(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY mediated|nsubjpass|Expression mediated|nmod|ligands ligands|compound|END_ENTITY	Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane_X_receptor ligands formed by enhanced cholesterol metabolism .
12814963	0	CYP3A	0,5	tumor_necrosis_factor-alpha_converting_enzyme	38,83	CYP3A	tumor necrosis factor-alpha converting enzyme	1576	6868	Gene	Gene	START_ENTITY|acl|induction induction|nmod|END_ENTITY	CYP3A induction by N-hydroxyformamide tumor_necrosis_factor-alpha_converting_enzyme / matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans .
21570957	0	CYP3A11	106,113	tumor_necrosis_factor-a	19,42	CYP3A11	tumor necrosis factor-a	13112(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Selective role for tumor_necrosis_factor-a , but not interleukin-1 or Kupffer cells , in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen .
17615053	0	CYP3A4	59,65	CYP11A1	75,82	CYP3A4	CYP11A1	1576	1583	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP3A4	59,65	CYP17A1	84,91	CYP3A4	CYP17A1	1576	1586	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
20218903	0	CYP3A4	33,39	CYP1A2	25,31	CYP3A4	CYP1A2	1576	1544	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|compound|END_ENTITY	Genetic polymorphisms of CYP1A2 , CYP3A4 , CYP3A5 , pregnane/steroid _ X_receptor and constitutive_androstane_receptor in 207 healthy Spanish volunteers .
17615053	0	CYP3A4	59,65	CYP1B1	51,57	CYP3A4	CYP1B1	1576	1545	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
15860655	0	CYP3A4	73,79	CYP2C19	89,96	CYP3A4	CYP2C19	1576	1557	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	Automated screening with confirmation of mechanism-based inactivation of CYP3A4 , CYP2C9 , CYP2C19 , CYP2D6 , and CYP1A2 in pooled human liver microsomes .
15860655	0	CYP3A4	73,79	CYP2C9	81,87	CYP3A4	CYP3A4	1576	1576	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	Automated screening with confirmation of mechanism-based inactivation of CYP3A4 , CYP2C9 , CYP2C19 , CYP2D6 , and CYP1A2 in pooled human liver microsomes .
22388796	0	CYP3A4	42,48	CYP3A4	8,14	CYP3A4	CYP3A4	1576	1576	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	The new CYP3A4 intron 6_C > T polymorphism -LRB- CYP3A4 * 22 -RRB- is associated with an increased risk of delayed_graft_function and worse renal function in cyclosporine-treated kidney transplant patients .
22388796	0	CYP3A4	8,14	CYP3A4	42,48	CYP3A4	CYP3A4	1576	1576	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	The new CYP3A4 intron 6_C > T polymorphism -LRB- CYP3A4 * 22 -RRB- is associated with an increased risk of delayed_graft_function and worse renal function in cyclosporine-treated kidney transplant patients .
23665933	0	CYP3A4	0,6	CYP3A4	34,40	CYP3A4	CYP3A4	1576	1576	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	CYP3A4 intron 6_C > T polymorphism -LRB- CYP3A4 * 22 -RRB- is associated with reduced CYP3A4 protein level and function in human liver microsomes .
23665933	0	CYP3A4	34,40	CYP3A4	0,6	CYP3A4	CYP3A4	1576	1576	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	CYP3A4 intron 6_C > T polymorphism -LRB- CYP3A4 * 22 -RRB- is associated with reduced CYP3A4 protein level and function in human liver microsomes .
12679136	0	CYP3A4	51,57	CYP3A5	70,76	CYP3A4	CYP3A5	1576	1577	Gene	Gene	expression|nmod|START_ENTITY Differential|dobj|expression Differential|advcl|END_ENTITY	Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5 , CYP3A7 and CYP3A43 .
14695543	0	CYP3A4	14,20	CYP3A5	50,56	CYP3A4	CYP3A5	1576	1577	Gene	Gene	Haplotypes|nmod|START_ENTITY linkage|nsubj|Haplotypes linkage|nmod|haplotypes haplotypes|nummod|END_ENTITY	Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population .
15342470	0	CYP3A4	119,125	CYP3A5	96,102	CYP3A4	CYP3A5	1576	1577	Gene	Gene	substrates|compound|START_ENTITY variability|nmod|substrates variability|nummod|END_ENTITY	Utility of recombinant enzyme kinetics in prediction of human clearance : impact of variability , CYP3A5 , and CYP2C19 on CYP3A4 probe substrates .
15634941	0	CYP3A4	93,99	CYP3A5	146,152	CYP3A4	CYP3A5	1576	1577	Gene	Gene	occur|dep|START_ENTITY occur|nmod|chromosome chromosome|nmod|END_ENTITY	Recombinant CYP3A4 * 17 is defective in metabolizing the hypertensive drug nifedipine , and the CYP3A4 * 17 allele may occur on the same chromosome as CYP3A5 * 3 , representing a new putative defective CYP3A haplotype .
16842392	0	CYP3A4	22,28	CYP3A5	30,36	CYP3A4	CYP3A5	1576	1577	Gene	Gene	CYP2J2|nummod|START_ENTITY CYP2J2|nummod|END_ENTITY	The effect of CYP2J2 , CYP3A4 , CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine : a pilot study .
17615053	0	CYP3A4	59,65	CYP3A5	67,73	CYP3A4	CYP3A5	1576	1577	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
18322448	0	CYP3A4	125,131	CYP3A5	21,27	CYP3A4	CYP3A5	1576	1577	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression Influence|dep|role Influence|nmod|END_ENTITY	Influence of CYP3A4 , CYP3A5 , and ABCB1 genotype and expression on budesonide pharmacokinetics : a possible role of intestinal CYP3A4 expression .
21635144	0	CYP3A4	14,20	CYP3A5	62,68	CYP3A4	CYP3A5	1576	1577	Gene	Gene	Impact|nmod|START_ENTITY Impact|nmod|genotypes genotypes|nummod|END_ENTITY	Impact of the CYP3A4 * 1G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients .
22871995	0	CYP3A4	8,14	CYP3A5	25,31	CYP3A4	CYP3A5	1576	1577	Gene	Gene	activity|compound|START_ENTITY genotype|nmod|activity genotype|nsubj|END_ENTITY	In vivo CYP3A4 activity , CYP3A5 genotype , and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients .
22993851	0	CYP3A4	11,17	CYP3A5	23,29	CYP3A4	CYP3A5	1576	1577	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	-LSB- Effect of CYP3A4 * 18B , CYP3A5 * 3 gene polymorphism on dosage and concentration of tacrolimus in renal transplant patients -RSB- .
23617933	0	CYP3A4	50,56	CYP3A5	61,67	CYP3A4	CYP3A5	1576	1577	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Biological interactions of CYP2C19 genotypes with CYP3A4 * 18 , CYP3A5 * 3 , and MDR1-3435 in living donor liver transplantation recipients .
24522145	0	CYP3A4	10,16	CYP3A5	21,27	CYP3A4	CYP3A5	1576	1577	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Effect of CYP3A4 * 22 , CYP3A5 * 3 , and CYP3A Combined Genotypes on Cyclosporine , Everolimus , and Tacrolimus Pharmacokinetics in Renal Transplantation .
25434721	0	CYP3A4	65,71	CYP3A5	18,24	CYP3A4	CYP3A5	1576	1577	Gene	Gene	inducibility|nmod|START_ENTITY attenuates|dobj|inducibility attenuates|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of CYP3A5 attenuates inducibility and activity of CYP3A4 in HepG2 cells .
26104034	0	CYP3A4	10,16	CYP3A5	21,27	CYP3A4	CYP3A5	1576	1577	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|3 3|compound|END_ENTITY	Effect of CYP3A4 * 1G , CYP3A5 * 3 , POR * 28 , and ABCB1 C3435T on the pharmacokinetics of nifedipine in healthy Chinese volunteers .
7811260	0	CYP3A4	72,78	CYP3A5	38,44	CYP3A4	CYP3A5	1576	1577	Gene	Gene	analysis|nmod|START_ENTITY Sequence|dep|analysis Sequence|nmod|5 5|dep|region region|nmod|END_ENTITY	Sequence of the 5 ' - flanking region of CYP3A5 : comparative analysis with CYP3A4 and CYP3A7 .
8946469	0	CYP3A4	39,45	CYP3A5	24,30	CYP3A4	CYP3A5	1576	1577	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Selective expression of CYP3A5 and not CYP3A4 in human blood .
18784074	0	CYP3A4	82,88	Cyclin-dependent_kinase_2	0,25	CYP3A4	Cyclin-dependent kinase 2	1576	1017	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cyclin-dependent_kinase_2 negatively regulates human pregnane_X_receptor-mediated CYP3A4 gene expression in HepG2 liver_carcinoma cells .
23291635	0	CYP3A4	59,65	Hepatocyte_nuclear_factor_6	0,27	CYP3A4	Hepatocyte nuclear factor 6	1576	3175	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Hepatocyte_nuclear_factor_6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells .
12172213	0	CYP3A4	80,86	MDR1	27,31	CYP3A4	MDR1	1576	5243	Gene	Gene	level|nmod|START_ENTITY affects|dobj|level affects|nsubj|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation .
12625868	0	CYP3A4	19,25	MDR1	45,49	CYP3A4	MDR1	1576	5243	Gene	Gene	ABC-transporters|compound|START_ENTITY ABC-transporters|appos|END_ENTITY	Gene expression of CYP3A4 , ABC-transporters -LRB- MDR1 and MRP1-MRP5 -RRB- and hPXR in three different human colon_carcinoma cell lines .
18636247	0	CYP3A4	21,27	MDR1	15,19	CYP3A4	MDR1	1576	5243	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of MDR1 , CYP3A4 * 18B , and CYP3A5 * 3 polymorphisms with cyclosporine pharmacokinetics in Chinese_renal_transplant_recipients .
19267185	0	CYP3A4	65,71	MDR1	0,4	CYP3A4	MDR1	1576	5243	Gene	Gene	expression|nmod|START_ENTITY conferring|dobj|expression haplotypes|xcomp|conferring haplotypes|nsubj|END_ENTITY	MDR1 haplotypes conferring an increased expression of intestinal CYP3A4 rather than MDR1 in female living-donor liver transplant patients .
17925385	0	CYP3A4	129,135	NR1I2	96,101	CYP3A4	NR1I2	1576	8856	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane_X_receptor / NR1I2 and their association with CYP3A4 expression .
20959500	0	CYP3A4	13,19	NR1I2	65,70	CYP3A4	NR1I2	1576	8856	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|Role Role|nmod|END_ENTITY	Induction of CYP3A4 by vinblastine : Role of the nuclear receptor NR1I2 .
22719896	0	CYP3A4	112,118	POR	77,80	CYP3A4	POR	1576	5447	Gene	Gene	activity|nmod|START_ENTITY Influence|nmod|activity Influence|appos|END_ENTITY	Influence of various polymorphic variants of cytochrome P450 oxidoreductase -LRB- POR -RRB- on drug metabolic activity of CYP3A4 and CYP2B6 .
23974086	0	CYP3A4	10,16	POR	21,24	CYP3A4	POR	1576	5447	Gene	Gene	*|compound|START_ENTITY *|dep|END_ENTITY	Effect of CYP3A4 * 22 , POR * 28 , and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients .
26104034	0	CYP3A4	10,16	POR	31,34	CYP3A4	POR	1576	5447	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of CYP3A4 * 1G , CYP3A5 * 3 , POR * 28 , and ABCB1 C3435T on the pharmacokinetics of nifedipine in healthy Chinese volunteers .
15548381	0	CYP3A4	59,65	PXR	2,5	CYP3A4	PXR	1576	8856	Gene	Gene	assay|dep|START_ENTITY assay|compound|END_ENTITY	A PXR reporter gene assay in a stable cell culture system : CYP3A4 and CYP2B6 induction by pesticides .
18332045	0	CYP3A4	23,29	PXR	75,78	CYP3A4	PXR	1576	8856	Gene	Gene	induction|nmod|START_ENTITY dependent|nsubj|induction dependent|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression .
18981011	0	CYP3A4	61,67	PXR	0,3	CYP3A4	PXR	1576	8856	Gene	Gene	haplotypes|nmod|START_ENTITY association|nmod|haplotypes pharmacogenetics|dep|association pharmacogenetics|compound|END_ENTITY	PXR pharmacogenetics : association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast_cancer patients .
19232333	0	CYP3A4	48,54	PXR	35,38	CYP3A4	PXR	1576	8856	Gene	Gene	expressions|compound|START_ENTITY PAR-2|nmod|expressions PAR-2|compound|END_ENTITY	The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions .
21641981	0	CYP3A4	22,28	PXR	76,79	CYP3A4	PXR	1576	8856	Gene	Gene	expression|compound|START_ENTITY expression|nmod|process process|acl:relcl|involves involves|dobj|factor factor|compound|END_ENTITY	Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor .
21920351	0	CYP3A4	76,82	PXR	42,45	CYP3A4	PXR	1576	8856	Gene	Gene	gene|compound|START_ENTITY transactivation|nmod|gene pregnane_X_receptor|dep|transactivation pregnane_X_receptor|appos|END_ENTITY	Metformin suppresses pregnane_X_receptor -LRB- PXR -RRB- - regulated transactivation of CYP3A4 gene .
22333269	0	CYP3A4	69,75	PXR	109,112	CYP3A4	PXR	1576	8856	Gene	Gene	induction|compound|START_ENTITY impair|dobj|induction impair|nmod|conditions conditions|acl:relcl|overexpressed overexpressed|nsubjpass|END_ENTITY	Lower expression of HNF4a and PGC1a might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells .
22363234	0	CYP3A4	61,67	PXR	152,155	CYP3A4	PXR	1576	8856	Gene	Gene	cytochrome_P450_3A4|appos|START_ENTITY cytochrome_P450_3A4|dep|expression expression|nmod|pregnane_X_receptor pregnane_X_receptor|appos|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
23330538	0	CYP3A4	49,55	PXR	35,38	CYP3A4	PXR	1576	8856	Gene	Gene	interactions|compound|START_ENTITY Evaluation|dep|interactions Evaluation|nmod|pregnane_X_receptor pregnane_X_receptor|appos|END_ENTITY	Evaluation of pregnane_X_receptor -LRB- PXR -RRB- - mediated CYP3A4 drug-drug interactions in drug development .
23845848	0	CYP3A4	49,55	PXR	78,81	CYP3A4	PXR	1576	8856	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Polycyclic_aromatic_hydrocarbons stimulate human CYP3A4 promoter activity via PXR .
25542144	0	CYP3A4	58,64	PXR	110,113	CYP3A4	PXR	1576	8856	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|advcl|activating activating|dobj|END_ENTITY	Diindolylmethane , a naturally occurring compound , induces CYP3A4 and MDR1 gene expression by activating human PXR .
26341324	0	CYP3A4	78,84	PXR	64,67	CYP3A4	PXR	1576	8856	Gene	Gene	pregnane_X_receptor|dep|START_ENTITY pregnane_X_receptor|appos|END_ENTITY	A food contaminant ochratoxin_A suppresses pregnane_X_receptor -LRB- PXR -RRB- - mediated CYP3A4 induction in primary cultures of human hepatocytes .
9727070	0	CYP3A4	78,84	PXR	34,37	CYP3A4	PXR	1576	8856	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression compounds|acl:relcl|regulate activated|nmod|compounds activated|nsubjpass|END_ENTITY	The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions .
25381754	0	CYP3A4	124,130	Pregnane_X_Receptor	82,101	CYP3A4	Pregnane X Receptor	1576	8856	Gene	Gene	Induction|compound|START_ENTITY Prediction|nmod|Induction END_ENTITY|nmod|Prediction	Three-Dimensional Quantitative Structure-Activity Relationship Analysis for Human Pregnane_X_Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes : Structure-Based Comparative Molecular Field Analysis .
17429319	0	CYP3A4	41,47	Pregnane_X_receptor	0,19	CYP3A4	Pregnane X receptor	1576	8856	Gene	Gene	induction|nummod|START_ENTITY affects|dobj|induction affects|nsubj|polymorphism polymorphism|compound|END_ENTITY	Pregnane_X_receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid_receptor_coactivator-1 .
16109480	0	CYP3A4	8,14	aryl_hydrocarbon_receptor	40,65	CYP3A4	aryl hydrocarbon receptor	1576	196	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of CYP3A4 in the regulation of the aryl_hydrocarbon_receptor by omeprazole_sulphide .
12130689	0	CYP3A4	40,46	constitutive_androstane_receptor	59,91	CYP3A4	constitutive androstane receptor	1576	9970	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the human CYP3A4 gene by the constitutive_androstane_receptor .
1391968	0	CYP3A4	66,72	cytochrome_P-450_nifedipine_oxidase	24,59	CYP3A4	cytochrome P-450 nifedipine oxidase	1576	1576	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human cytochrome_P-450_nifedipine_oxidase gene -LRB- CYP3A4 -RRB- to chromosome 7 at band q22 .1 by fluorescence in situ hybridization .
11753266	0	CYP3A4	104,110	cytochrome_P450_3A4	83,102	CYP3A4	cytochrome P450 3A4	1576	1576	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- activity in humans .
23295386	0	CYP3A4	72,78	cytochrome_P450_3A4	51,70	CYP3A4	cytochrome P450 3A4	1576	1576	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Direct transcriptional regulation of human hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARa -RRB- .
12477485	0	CYP3A4	223,229	glucocorticoid_receptor	33,56	CYP3A4	glucocorticoid receptor	1576	2908	Gene	Gene	inducers|nummod|START_ENTITY series|nmod|inducers relationships|nmod|series Molecular|dep|relationships Molecular|nmod|END_ENTITY	Molecular modelling of the human glucocorticoid_receptor -LRB- hGR -RRB- ligand-binding_domain -LRB- LBD -RRB- by homology with the human estrogen_receptor_alpha -LRB- hERalpha -RRB- LBD : quantitative structure-activity relationships within a series of CYP3A4 inducers where induction is mediated via hGR involvement .
12673034	1	CYP3A4	86,92	glucocorticoid_receptor	111,134	CYP3A4	glucocorticoid receptor	1576	2908	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association between induction of CYP3A4 and expression of glucocorticoid_receptor .
25141173	0	CYP3A4	47,53	glucocorticoid_receptor	94,117	CYP3A4	glucocorticoid receptor	1576	2908	Gene	Gene	START_ENTITY|nmod|hepatocytes hepatocytes|nmod|END_ENTITY	Omeprazole and lansoprazole enantiomers induce CYP3A4 in human hepatocytes and cell lines via glucocorticoid_receptor and pregnane X receptor axis .
19103148	0	CYP3A4	0,6	gp78	25,29	CYP3A4	gp78	1576	267	Gene	Gene	ubiquitination|nsubj|START_ENTITY ubiquitination|nmod|END_ENTITY	CYP3A4 ubiquitination by gp78 -LRB- the tumor autocrine_motility_factor_receptor , AMFR -RRB- and CHIP E3 ligases .
16455805	0	CYP3A4	24,30	hepatocyte_nuclear_factor_4alpha	76,108	CYP3A4	hepatocyte nuclear factor 4alpha	1576	3172	Gene	Gene	induction|nmod|START_ENTITY requires|nsubj|induction requires|dobj|talk talk|nmod|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
17344340	0	CYP3A4	29,35	hepatocyte_nuclear_factor_4alpha	50,82	CYP3A4	hepatocyte nuclear factor 4alpha	1576	3172	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Molecular mechanism of basal CYP3A4 regulation by hepatocyte_nuclear_factor_4alpha : evidence for direct regulation in the intestine .
23732298	0	CYP3A4	64,70	liver_X_receptor_a	31,49	CYP3A4	liver X receptor a	1576	10062	Gene	Gene	expression|compound|START_ENTITY roles|nmod|expression roles|nmod|END_ENTITY	Dual roles of nuclear receptor liver_X_receptor_a -LRB- LXRa -RRB- in the CYP3A4 expression in human hepatocytes as a positive and negative regulator .
23295386	0	CYP3A4	72,78	peroxisome_proliferator-activated_receptor_alpha	83,131	CYP3A4	peroxisome proliferator-activated receptor alpha	1576	5465	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Direct transcriptional regulation of human hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARa -RRB- .
10570062	0	CYP3A4	80,86	pregnane_X_receptor	17,36	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	The orphan human pregnane_X_receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module .
10908304	0	CYP3A4	129,135	pregnane_X_receptor	149,168	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	induction|compound|START_ENTITY increase|nmod|induction expression|dep|increase induces|dobj|expression induces|nmod|activators activators|compound|END_ENTITY	Dexamethasone induces pregnane_X_receptor and retinoid_X_receptor-alpha expression in human hepatocytes : synergistic increase of CYP3A4 induction by pregnane_X_receptor activators .
10908304	0	CYP3A4	129,135	pregnane_X_receptor	22,41	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	induction|compound|START_ENTITY increase|nmod|induction expression|dep|increase expression|compound|END_ENTITY	Dexamethasone induces pregnane_X_receptor and retinoid_X_receptor-alpha expression in human hepatocytes : synergistic increase of CYP3A4 induction by pregnane_X_receptor activators .
11602521	0	CYP3A4	93,99	pregnane_X_receptor	28,47	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	activity|nmod|START_ENTITY variants|nmod|activity variants|nmod|END_ENTITY	Natural protein variants of pregnane_X_receptor with altered transactivation activity toward CYP3A4 .
12065438	0	CYP3A4	0,6	pregnane_X_receptor	49,68	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	induction|nummod|START_ENTITY induction|dep|correlation correlation|nmod|assay assay|compound|END_ENTITY	CYP3A4 induction by drugs : correlation between a pregnane_X_receptor reporter gene assay and CYP3A4 expression in human hepatocytes .
12167569	0	CYP3A4	37,43	pregnane_X_receptor	119,138	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	induction|nmod|START_ENTITY decreased|nsubjpass|induction decreased|parataxis|interaction interaction|nmod|element element|compound|END_ENTITY	Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein : DNA interaction distinct from the pregnane_X_receptor response element .
16455805	0	CYP3A4	24,30	pregnane_X_receptor	40,59	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	induction|nmod|START_ENTITY requires|nsubj|induction requires|dobj|talk talk|compound|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
17293382	0	CYP3A4	88,94	pregnane_X_receptor	20,39	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	gene|compound|START_ENTITY Assessment|nmod|gene Assessment|nmod|involvement involvement|compound|END_ENTITY	Assessment of human pregnane_X_receptor involvement in pesticide-mediated activation of CYP3A4 gene .
17764444	0	CYP3A4	36,42	pregnane_X_receptor	113,132	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	gene|compound|START_ENTITY enhancers|nmod|gene co-ordinate|nsubj|enhancers co-ordinate|advcl|responding responding|nmod|END_ENTITY	The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane_X_receptor but differentially to hepatocyte_nuclear_factor-4alpha .
19077665	0	CYP3A4	14,20	pregnane_X_receptor	81,100	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	expression|nummod|START_ENTITY Inhibition|nmod|expression mediated|nsubjpass|Inhibition mediated|nmod|disruption disruption|nmod|END_ENTITY	Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane_X_receptor , steroid receptor coactivator-1 , and hepatocyte_nuclear_factor_4alpha interaction .
19297428	0	CYP3A4	6,12	pregnane_X_receptor	77,96	CYP3A4	pregnane X receptor	1576	18171(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|equol equol|nmod|END_ENTITY	Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane_X_receptor in a species-specific manner .
21920351	0	CYP3A4	76,82	pregnane_X_receptor	21,40	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	gene|compound|START_ENTITY transactivation|nmod|gene END_ENTITY|dep|transactivation	Metformin suppresses pregnane_X_receptor -LRB- PXR -RRB- - regulated transactivation of CYP3A4 gene .
22076448	0	CYP3A4	42,48	pregnane_X_receptor	82,101	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	transcription|nummod|START_ENTITY activate|dobj|transcription activate|nmod|END_ENTITY	Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane_X_receptor .
22363234	0	CYP3A4	61,67	pregnane_X_receptor	131,150	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	cytochrome_P450_3A4|appos|START_ENTITY cytochrome_P450_3A4|dep|expression expression|nmod|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
22648626	0	CYP3A4	18,24	pregnane_X_receptor	40,59	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Capsaicin induces CYP3A4 expression via pregnane_X_receptor and CCAAT/enhancer-binding _ protein_b activation .
23330538	0	CYP3A4	49,55	pregnane_X_receptor	14,33	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	interactions|compound|START_ENTITY Evaluation|dep|interactions Evaluation|nmod|END_ENTITY	Evaluation of pregnane_X_receptor -LRB- PXR -RRB- - mediated CYP3A4 drug-drug interactions in drug development .
23928187	0	CYP3A4	27,33	pregnane_X_receptor	109,128	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity binding|nsubj|regulation binding|xcomp|END_ENTITY	Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane_X_receptor .
23977680	0	CYP3A4	113,119	pregnane_X_receptor	73,92	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	element|compound|START_ENTITY activity|nmod|element activity|compound|END_ENTITY	A nonradioactive electrophoretic mobility shift assay for measurement of pregnane_X_receptor binding activity to CYP3A4 response element .
26782648	0	CYP3A4	65,71	pregnane_X_receptor	15,34	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|SUMOylation SUMOylation|nmod|END_ENTITY	SUMOylation of pregnane_X_receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells .
26987505	0	CYP3A4	49,55	pregnane_X_receptor	93,112	CYP3A4	pregnane X receptor	1576	8856	Gene	Gene	transcription|nummod|START_ENTITY activates|dobj|transcription activates|nmod|END_ENTITY	Indirubin , a component of Ban-Lan-Gen , activates CYP3A4 gene transcription through the human pregnane_X_receptor .
11560479	0	CYP3A4	44,50	protein_kinase_C	54,70	CYP3A4	protein kinase C	1576	112476	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of native and heme-modified CYP3A4 by protein_kinase_C : a mass spectrometric characterization of the phosphorylated peptides .
14695544	0	CYP3A43	68,75	cytochrome_P450_3A43	46,66	CYP3A43	cytochrome P450 3A43	64816	64816	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	First report of a genetic polymorphism of the cytochrome_P450_3A43 -LRB- CYP3A43 -RRB- gene : identification of a loss-of-function variant .
12766253	0	CYP3A4_and_multiple_drug_resistance_protein_1	18,63	pregnane_X_receptor	106,125	CYP3A4 and multiple drug resistance protein 1	pregnane X receptor	1576	8856	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Avasimibe induces CYP3A4_and_multiple_drug_resistance_protein_1 gene expression through activation of the pregnane_X_receptor .
15167702	0	CYP3A5	14,20	ABCB1	31,36	CYP3A5	ABCB1	1577	5243	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients .
15502717	0	CYP3A5	13,19	ABCB1	30,35	CYP3A5	ABCB1	1577	5243	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients .
15919447	0	CYP3A5	10,16	ABCB1	26,31	CYP3A5	ABCB1	1577	5243	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- C3435T polymorphisms on the pharmacokinetics of tacrolimus in renal transplant recipients .
21094796	0	CYP3A5	13,19	ABCB1	29,34	CYP3A5	ABCB1	1577	5243	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of CYP3A5 and MDR1 -LRB- ABCB1 -RRB- polymorphisms on the pharmacokinetics of tacrolimus in Chinese_renal_transplant_recipients .
17615053	0	CYP3A5	67,73	CYP11A1	75,82	CYP3A5	CYP11A1	1577	1583	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
17615053	0	CYP3A5	67,73	CYP17A1	84,91	CYP3A5	CYP17A1	1577	1586	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
21907728	0	CYP3A5	41,47	CYP1A1	33,39	CYP3A5	CYP1A1	1577	1543	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	Role of genetic polymorphisms of CYP1A1 , CYP3A5 , CYP2C9 , CYP2D6 , and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides .
17615053	0	CYP3A5	67,73	CYP1B1	51,57	CYP3A5	CYP1B1	1577	1545	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
26367500	0	CYP3A5	18,24	CYP2A6	35,41	CYP3A5	CYP2A6	1577	1548	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
22771593	0	CYP3A5	38,44	CYP2C19	28,35	CYP3A5	CYP2C19	1577	1557	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Functional polymorphisms in CYP2C19 _ CYP3A5 genes associated with decreased susceptibility for paediatric tuberculosis .
26367500	0	CYP3A5	18,24	CYP2C19	26,33	CYP3A5	CYP2C19	1577	1557	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
14676821	0	CYP3A5	40,46	CYP2C9	32,38	CYP3A5	CYP2C9	1577	1559	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	Warfarin sensitivity related to CYP2C9 , CYP3A5 , ABCB1 -LRB- MDR1 -RRB- and other factors .
21907728	0	CYP3A5	41,47	CYP2C9	49,55	CYP3A5	CYP2C9	1577	1559	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	Role of genetic polymorphisms of CYP1A1 , CYP3A5 , CYP2C9 , CYP2D6 , and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides .
19946748	0	CYP3A5	10,16	CYP2D6	0,6	CYP3A5	CYP2D6	1577	1565	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	CYP2D6 * 4 , CYP3A5 * 3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people .
22718623	0	CYP3A5	22,28	CYP2D6	11,17	CYP3A5	CYP2D6	1577	1565	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Effects of CYP2D6 * 10 , CYP3A5 * 3 , CYP1A2 * 1F , and ABCB1 C3435T polymorphisms on the pharmacokinetics of flecainide in healthy Chinese subjects .
26367500	0	CYP3A5	18,24	CYP2D6	10,16	CYP3A5	CYP2D6	1577	1565	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
12679136	0	CYP3A5	70,76	CYP3A4	51,57	CYP3A5	CYP3A4	1577	1576	Gene	Gene	Differential|advcl|START_ENTITY Differential|dobj|expression expression|nmod|END_ENTITY	Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5 , CYP3A7 and CYP3A43 .
14695543	0	CYP3A5	50,56	CYP3A4	14,20	CYP3A5	CYP3A4	1577	1576	Gene	Gene	haplotypes|nummod|START_ENTITY linkage|nmod|haplotypes linkage|nsubj|Haplotypes Haplotypes|nmod|END_ENTITY	Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population .
15342470	0	CYP3A5	96,102	CYP3A4	119,125	CYP3A5	CYP3A4	1577	1576	Gene	Gene	variability|nummod|START_ENTITY variability|nmod|substrates substrates|compound|END_ENTITY	Utility of recombinant enzyme kinetics in prediction of human clearance : impact of variability , CYP3A5 , and CYP2C19 on CYP3A4 probe substrates .
15634941	0	CYP3A5	146,152	CYP3A4	93,99	CYP3A5	CYP3A4	1577	1576	Gene	Gene	chromosome|nmod|START_ENTITY occur|nmod|chromosome occur|dep|END_ENTITY	Recombinant CYP3A4 * 17 is defective in metabolizing the hypertensive drug nifedipine , and the CYP3A4 * 17 allele may occur on the same chromosome as CYP3A5 * 3 , representing a new putative defective CYP3A haplotype .
16842392	0	CYP3A5	30,36	CYP3A4	22,28	CYP3A5	CYP3A4	1577	1576	Gene	Gene	CYP2J2|nummod|START_ENTITY CYP2J2|nummod|END_ENTITY	The effect of CYP2J2 , CYP3A4 , CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine : a pilot study .
17615053	0	CYP3A5	67,73	CYP3A4	59,65	CYP3A5	CYP3A4	1577	1576	Gene	Gene	CYP19A1|appos|START_ENTITY CYP19A1|appos|END_ENTITY	Polymorphisms in the cytochrome P450 genes CYP1A2 , CYP1B1 , CYP3A4 , CYP3A5 , CYP11A1 , CYP17A1 , CYP19A1 and colorectal_cancer risk .
18322448	0	CYP3A5	21,27	CYP3A4	125,131	CYP3A5	CYP3A4	1577	1576	Gene	Gene	Influence|nmod|START_ENTITY Influence|dep|role role|nmod|expression expression|compound|END_ENTITY	Influence of CYP3A4 , CYP3A5 , and ABCB1 genotype and expression on budesonide pharmacokinetics : a possible role of intestinal CYP3A4 expression .
21635144	0	CYP3A5	62,68	CYP3A4	14,20	CYP3A5	CYP3A4	1577	1576	Gene	Gene	genotypes|nummod|START_ENTITY Impact|nmod|genotypes Impact|nmod|END_ENTITY	Impact of the CYP3A4 * 1G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients .
22871995	0	CYP3A5	25,31	CYP3A4	8,14	CYP3A5	CYP3A4	1577	1576	Gene	Gene	genotype|nsubj|START_ENTITY genotype|nmod|activity activity|compound|END_ENTITY	In vivo CYP3A4 activity , CYP3A5 genotype , and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients .
22993851	0	CYP3A5	23,29	CYP3A4	11,17	CYP3A5	CYP3A4	1577	1576	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	-LSB- Effect of CYP3A4 * 18B , CYP3A5 * 3 gene polymorphism on dosage and concentration of tacrolimus in renal transplant patients -RSB- .
23617933	0	CYP3A5	61,67	CYP3A4	50,56	CYP3A5	CYP3A4	1577	1576	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Biological interactions of CYP2C19 genotypes with CYP3A4 * 18 , CYP3A5 * 3 , and MDR1-3435 in living donor liver transplantation recipients .
24522145	0	CYP3A5	21,27	CYP3A4	10,16	CYP3A5	CYP3A4	1577	1576	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Effect of CYP3A4 * 22 , CYP3A5 * 3 , and CYP3A Combined Genotypes on Cyclosporine , Everolimus , and Tacrolimus Pharmacokinetics in Renal Transplantation .
25434721	0	CYP3A5	18,24	CYP3A4	65,71	CYP3A5	CYP3A4	1577	1576	Gene	Gene	Overexpression|nmod|START_ENTITY attenuates|nsubj|Overexpression attenuates|dobj|inducibility inducibility|nmod|END_ENTITY	Overexpression of CYP3A5 attenuates inducibility and activity of CYP3A4 in HepG2 cells .
26104034	0	CYP3A5	21,27	CYP3A4	10,16	CYP3A5	CYP3A4	1577	1576	Gene	Gene	3|compound|START_ENTITY Effect|appos|3 Effect|nmod|END_ENTITY	Effect of CYP3A4 * 1G , CYP3A5 * 3 , POR * 28 , and ABCB1 C3435T on the pharmacokinetics of nifedipine in healthy Chinese volunteers .
7811260	0	CYP3A5	38,44	CYP3A4	72,78	CYP3A5	CYP3A4	1577	1576	Gene	Gene	region|nmod|START_ENTITY 5|dep|region Sequence|nmod|5 Sequence|dep|analysis analysis|nmod|END_ENTITY	Sequence of the 5 ' - flanking region of CYP3A5 : comparative analysis with CYP3A4 and CYP3A7 .
8946469	0	CYP3A5	24,30	CYP3A4	39,45	CYP3A5	CYP3A4	1577	1576	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Selective expression of CYP3A5 and not CYP3A4 in human blood .
21513075	0	CYP3A5	13,19	CYP3A5	59,65	CYP3A5	CYP3A5	1577	1577	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of CYP3A5 * 3 polymorphism and interaction between CYP3A5 * 3 and CYP3A4 * 1G polymorphisms on post-operative fentanyl analgesia in Chinese patients undergoing gynaecological surgery .
21513075	0	CYP3A5	59,65	CYP3A5	13,19	CYP3A5	CYP3A5	1577	1577	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of CYP3A5 * 3 polymorphism and interaction between CYP3A5 * 3 and CYP3A4 * 1G polymorphisms on post-operative fentanyl analgesia in Chinese patients undergoing gynaecological surgery .
14676821	0	CYP3A5	40,46	MDR1	55,59	CYP3A5	MDR1	1577	5243	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Warfarin sensitivity related to CYP2C9 , CYP3A5 , ABCB1 -LRB- MDR1 -RRB- and other factors .
26367500	0	CYP3A5	18,24	SLCO1B1	43,50	CYP3A5	SLCO1B1	1577	10599	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
21528942	0	CYP3A5	34,40	cytochrome_P450_3A5	13,32	CYP3A5	cytochrome P450 3A5	1577	1577	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Influence of cytochrome_P450_3A5 -LRB- CYP3A5 -RRB- genetic polymorphism on the pharmacokinetics of the prolonged-release , once-daily formulation of tacrolimus in stable renal transplant recipients .
23624173	0	CYP3A65	24,31	AHR2	49,53	CYP3A65	AHR2	553969(Tax:7955)	30517(Tax:7955)	Gene	Gene	Regulation|nmod|START_ENTITY transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of zebrafish CYP3A65 transcription by AHR2 .
8597156	0	CYP3A7	14,20	cytochrome_P450	45,60	CYP3A7	cytochrome P450	1551	4051	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of CYP3A7 , a human fetus-specific cytochrome_P450 , in cultured cells and in the hepatocytes of p53-knockout mice .
9439609	0	CYP3A9	37,43	growth_hormone	78,92	CYP3A9	growth hormone	171352(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Sexually dimorphic expression of rat CYP3A9 and CYP3A18 genes is regulated by growth_hormone .
8914854	0	CYP4A11	18,25	lauric_acid_omega-hydroxylase	39,68	CYP4A11	lauric acid omega-hydroxylase	1579	1579	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of CYP4A11 as the major lauric_acid_omega-hydroxylase in human liver microsomes .
21791872	0	CYP4B1	84,90	CYP2A13	75,82	CYP4B1	CYP2A13	1580	1553	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
21791872	0	CYP4B1	84,90	CYP2A6	67,73	CYP4B1	CYP2A6	1580	1548	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
21791872	0	CYP4B1	84,90	SULT1A1	92,99	CYP4B1	SULT1A1	1580	6817	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
15163554	0	CYP4F12	99,106	cytochrome_P450_4F12	77,97	CYP4F12	cytochrome P450 4F12	66002	66002	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Functional characterization of genetic polymorphisms identified in the human cytochrome_P450_4F12 -LRB- CYP4F12 -RRB- promoter region .
10492403	0	CYP4F2	82,88	leukotriene_B4_omega-hydroxylase	48,80	CYP4F2	leukotriene B4 omega-hydroxylase	8529	4051	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression and molecular cloning of human liver leukotriene_B4_omega-hydroxylase -LRB- CYP4F2 -RRB- gene .
9539102	0	CYP4F3	40,46	leukotriene_B4_omega-hydroxylase	6,38	CYP4F3	leukotriene B4 omega-hydroxylase	4051	4051	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human leukotriene_B4_omega-hydroxylase -LRB- CYP4F3 -RRB- gene : molecular cloning and chromosomal localization .
12384299	0	CYP4F5	61,67	cytochrome_P450_4F5	40,59	CYP4F5	cytochrome P450 4F5	286905(Tax:10116)	286905(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of the rat cytochrome_P450_4F5 -LRB- CYP4F5 -RRB- gene .
19661213	0	CYP4V2	35,41	fatty_acid_omega-hydroxylase	47,75	CYP4V2	fatty acid omega-hydroxylase	285440	1579	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and characterization of CYP4V2 as a fatty_acid_omega-hydroxylase .
18775413	0	CYP51	43,48	CREM	0,4	CYP51	CREM	13121(Tax:10090)	12916(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	CREM modulates the circadian expression of CYP51 , HMGCR and cholesterogenesis in the liver .
12145339	0	CYP51	124,129	lanosterol_14alpha-demethylase	87,117	CYP51	lanosterol 14alpha-demethylase	1595	1595	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol_14alpha-demethylase gene -LRB- CYP51 -RRB- .
18466759	0	CYP51	57,62	lanosterol_14alpha-demethylase	25,55	CYP51	lanosterol 14alpha-demethylase	1595	1595	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of microsomal lanosterol_14alpha-demethylase -LRB- CYP51 -RRB- in an engineered soluble monomeric form .
8975714	0	CYP51	72,77	lanosterol_14alpha-demethylase	35,65	CYP51	lanosterol 14alpha-demethylase	1595	1595	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and mapping of the human lanosterol_14alpha-demethylase gene -LRB- CYP51 -RRB- encoding the cytochrome_P450 involved in cholesterol biosynthesis ; comparison of exon/intron organization with other mammalian and fungal CYP genes .
10788789	0	CYP51	49,54	sterol_14alpha-demethylase	21,47	CYP51	sterol 14alpha-demethylase	403334(Tax:9823)	403334(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure of the pig sterol_14alpha-demethylase -LRB- CYP51 -RRB- gene and its expression in the testis and other tissues .
19149177	0	CYP51	41,46	sterol_14alpha-demethylase	13,39	CYP51	sterol 14alpha-demethylase	1595	1595	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Advances in sterol_14alpha-demethylase -LRB- CYP51 -RRB- -RSB- .
8995791	0	CYP6A2	66,72	cytochrome_P450	44,59	CYP6A2	cytochrome P450	35587(Tax:7227)	35587(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inducibility of the Drosophila_melanogaster cytochrome_P450 gene , CYP6A2 , by phenobarbital in insecticide susceptible or resistant strains .
1358792	0	CYP7	59,63	cholesterol_7_alpha-hydroxylase	21,52	CYP7	cholesterol 7 alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the human cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- and localization to chromosome 8q11-q12 .
8020987	0	CYP7	86,90	cholesterol_7_alpha-hydroxylase	48,79	CYP7	cholesterol 7 alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and nucleotide sequences of the human cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- .
8105753	0	CYP7	95,99	cholesterol_7_alpha-hydroxylase	57,88	CYP7	cholesterol 7 alpha-hydroxylase	25428(Tax:10116)	25428(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic cloning , sequencing , and analysis of the hamster cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- .
8656080	0	CYP7	65,69	cholesterol_7_alpha-hydroxylase	27,58	CYP7	cholesterol 7 alpha-hydroxylase	25428(Tax:10116)	25428(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hormonal regulation of the cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- .
9521095	0	CYP7	48,52	cholesterol_7_alpha-hydroxylase	15,46	CYP7	cholesterol 7 alpha-hydroxylase	448985(Tax:9823)	448985(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alleles of the cholesterol_7_alpha-hydroxylase -LRB- CYP7 -RRB- gene in pigs selected for high or low plasma total cholesterol .
26521940	0	CYP7A1	22,28	HIF-1a	39,45	CYP7A1	HIF-1a	1581	3091	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|END_ENTITY	Hypoxic Repression of CYP7A1 through a HIF-1a - and SHP-Independent Mechanism .
15796896	0	CYP7A1	102,108	HNF-4alpha	73,83	CYP7A1	HNF-4alpha	1581	3172	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Feedback regulation of bile_acid synthesis in human liver : importance of HNF-4alpha for regulation of CYP7A1 .
16489206	0	CYP7A1	115,121	LXRalpha	79,87	CYP7A1	LXRalpha	100328551(Tax:9986)	100352900(Tax:9986)	Gene	Gene	promoter|compound|START_ENTITY site|nmod|promoter site|compound|END_ENTITY	The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a LXRalpha binding site in the rabbit CYP7A1 promoter .
20715096	0	CYP7A1	171,177	Niemann-Pick_C1_like_1	78,100	CYP7A1	Niemann-Pick C1 like 1	1581	29881	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Dietary calcium decreases plasma cholesterol by down-regulation of intestinal Niemann-Pick_C1_like_1 and microsomal triacylglycerol transport protein and up-regulation of CYP7A1 and ABCG_5 / 8 in hamsters .
14522988	0	CYP7A1	21,27	PGC-1alpha	0,10	CYP7A1	PGC-1alpha	13122(Tax:10090)	19017(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	PGC-1alpha activates CYP7A1 and bile_acid biosynthesis .
10627496	0	CYP7A1	98,104	cholesterol_7alpha-hydroxylase	61,91	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	HNF4 and COUP-TFII interact to modulate transcription of the cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- .
10744771	0	CYP7A1	118,124	cholesterol_7alpha-hydroxylase	81,111	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- and agonist inhibit cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- transcription .
11402042	0	CYP7A1	128,134	cholesterol_7alpha-hydroxylase	91,121	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The negative effects of bile_acids and tumor_necrosis_factor-alpha on the transcription of cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- converge to hepatic nuclear factor-4 : a novel mechanism of feedback regulation of bile_acid synthesis mediated by nuclear receptors .
11967256	0	CYP7A1	86,92	cholesterol_7alpha-hydroxylase	49,79	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dietary cholesterol fails to stimulate the human cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- in transgenic_mice .
12093894	0	CYP7A1	38,44	cholesterol_7alpha-hydroxylase	6,36	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Human cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- deficiency has a hypercholesterolemic phenotype .
14960721	0	CYP7A1	65,71	cholesterol_7alpha-hydroxylase	28,58	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The inhibition of the human cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome_proliferator-activated_receptor_alpha heterodimer .
15479137	0	CYP7A1	63,69	cholesterol_7alpha-hydroxylase	31,61	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The A-204C polymorphism in the cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- gene determines the cholesterolemia responsiveness to a high-fat diet .
15629111	0	CYP7A1	64,70	cholesterol_7alpha-hydroxylase	32,62	CYP7A1	cholesterol 7alpha-hydroxylase	414834(Tax:9031)	414834(Tax:9031)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Species-specific mechanisms for cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- regulation by drugs and bile_acids .
19537927	0	CYP7A1	67,73	cholesterol_7alpha-hydroxylase	35,65	CYP7A1	cholesterol 7alpha-hydroxylase	1581	1581	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regulation of diurnal variation of cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- activity in healthy subjects .
11470525	0	CYP7B1	72,78	Sp1	83,86	CYP7B1	Sp1	9420	6667	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of human oxysterol_7_alpha-hydroxylase gene -LRB- CYP7B1 -RRB- by Sp1 .
12029625	0	CYP7B1	44,50	oxysterol_7alpha-hydroxylase	14,42	CYP7B1	oxysterol 7alpha-hydroxylase	25429(Tax:10116)	25429(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of oxysterol_7alpha-hydroxylase -LRB- CYP7B1 -RRB- in primary cultures of rat hepatocytes .
12759897	0	CYP7B1	44,50	oxysterol_7alpha-hydroxylase	14,42	CYP7B1	oxysterol 7alpha-hydroxylase	25429(Tax:10116)	25429(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of oxysterol_7alpha-hydroxylase -LRB- CYP7B1 -RRB- in the rat .
10051404	0	CYP8B1	77,83	sterol_12alpha-hydroxylase	44,70	CYP8B1	sterol 12alpha-hydroxylase	1582	1582	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and chromosomal assignment of the sterol_12alpha-hydroxylase gene -LRB- CYP8B1 -RRB- in human and mouse : eukaryotic cytochrome_P-450 gene devoid of introns .
11535594	0	CYP8B1	73,79	sterol_12alpha-hydroxylase	40,66	CYP8B1	sterol 12alpha-hydroxylase	1582	1582	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the human sterol_12alpha-hydroxylase gene -LRB- CYP8B1 -RRB- : roles of heaptocyte nuclear factor 4alpha in mediating bile_acid repression .
2121542	0	CYPIA1	31,37	cytochrome_P-450	14,30	CYPIA1	cytochrome P-450	13076(Tax:10090)	13079(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of cytochrome_P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes .
9345309	0	CYP_1A1	111,118	interleukin-1_beta	24,42	CYP 1A1	interleukin-1 beta	100328613(Tax:9986)	100008990(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Differential effects of interleukin-1_beta , interleukin-2 , and interferon-gamma on the inducible expression of CYP_1A1 and CYP_1A2 in cultured rabbit hepatocytes .
9521761	0	CYP_27	66,72	sterol_27-hydroxylase	38,59	CYP 27	sterol 27-hydroxylase	1593	1593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Silent nucleotide substitution in the sterol_27-hydroxylase gene -LRB- CYP_27 -RRB- leads to alternative pre-mRNA splicing by activating a cryptic 5 ' splice site at the mutant codon in cerebrotendinous_xanthomatosis patients .
9548584	0	CYP_27	65,71	sterol_27-hydroxylase	37,58	CYP 27	sterol 27-hydroxylase	1593	1593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternative pre-mRNA splicing of the sterol_27-hydroxylase gene -LRB- CYP_27 -RRB- caused by a G to A mutation at the last nucleotide of exon 6 in a patient with cerebrotendinous_xanthomatosis -LRB- CTX -RRB- .
17699553	0	CYR61	20,25	CCN1	14,18	CYR61	CCN1	3491	3491	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CCN1 -LRB- CYR61 -RRB- in developing , normal , and diseased human kidney .
22169285	0	CYR61	15,20	CTGF	22,26	CYR61	CTGF	3491	1490	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
15389821	0	CYR61	26,31	CYR61	82,87	CYR61	CYR61	3491	3491	Gene	Gene	START_ENTITY|nmod|cells cells|dep|END_ENTITY	Induction and function of CYR61 -LRB- CCN1 -RRB- in prostatic stromal and epithelial cells : CYR61 is required for prostatic cell proliferation .
15389821	0	CYR61	82,87	CYR61	26,31	CYR61	CYR61	3491	3491	Gene	Gene	cells|dep|START_ENTITY END_ENTITY|nmod|cells	Induction and function of CYR61 -LRB- CCN1 -RRB- in prostatic stromal and epithelial cells : CYR61 is required for prostatic cell proliferation .
22401280	0	CYR61	48,53	Epidermal_growth_factor	0,23	CYR61	Epidermal growth factor	3491	1950	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Epidermal_growth_factor upregulates endometrial CYR61 expression via activation of the JAK2/STAT3 pathway .
17234971	0	CYR61	96,101	FOXO3a	30,36	CYR61	FOXO3a	83476(Tax:10116)	294515(Tax:10116)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61 , leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia .
23045290	0	CYR61	33,38	IGFBP10	40,47	CYR61	IGFBP10	3491	3491	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A functional polymorphism in the CYR61 -LRB- IGFBP10 -RRB- gene is associated with prostate_cancer risk .
20452491	0	CYR61	60,65	MicroRNA-155	0,12	CYR61	MicroRNA-155	3491	406947	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	MicroRNA-155 contributes to preeclampsia by down-regulating CYR61 .
22169285	0	CYR61	15,20	VEGF-C	28,34	CYR61	VEGF-C	3491	7424	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
22169285	0	CYR61	15,20	VEGFR-2	36,43	CYR61	VEGFR-2	3491	3791	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
12105167	0	CYR61	14,19	angiotensin_II	99,113	CYR61	angiotensin II	3491	183	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CYR61 , an angiogenic immediate early gene , in arteriosclerosis and its regulation by angiotensin_II .
20641097	0	CYR61	54,59	cysteine_rich_protein_61	28,52	CYR61	cysteine rich protein 61	3491	3491	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Embryonic expression of the cysteine_rich_protein_61 -LRB- CYR61 -RRB- gene : A candidate for the development of human epispadias .
22078465	0	CYR61	0,5	p53	15,18	CYR61	p53	3491	7157	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	CYR61 controls p53 and NF-kB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian_cancer cells .
22023263	0	CYR61	0,5	vascular_endothelial_growth_factor_C	20,56	CYR61	vascular endothelial growth factor C	3491	7424	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	CYR61 modulates the vascular_endothelial_growth_factor_C expression of decidual NK cells via PI3K/AKT pathway .
17608974	0	CYR_61	63,69	CCN1	57,61	CYR 61	CCN1	3491	3491	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effects of schizophrenomimetics on the expression of the CCN1 -LRB- CYR_61 -RRB- gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat .
1577698	0	CYS3	36,40	CYI1	42,46	CYS3	CYI1	851221(Tax:4932)	851221(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of the CYS3 -LRB- CYI1 -RRB- gene of Saccharomyces_cerevisiae .
16846449	0	CYSLTR1	66,73	cysteinyl-leukotriene_type-1_receptor	27,64	CYSLTR1	cysteinyl-leukotriene type-1 receptor	10800	10800	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	927T > C polymorphism of the cysteinyl-leukotriene_type-1_receptor -LRB- CYSLTR1 -RRB- gene in children with asthma and atopic_dermatitis .
21609829	0	CYY-1	0,5	cyclin_Y	6,14	CYY-1	cyclin Y	176188(Tax:6239)	176188(Tax:6239)	Gene	Gene	/|compound|START_ENTITY /|amod|END_ENTITY	CYY-1 / cyclin_Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits .
23688010	0	C_reactive_protein	8,26	CRP	28,31	C reactive protein	CRP	1401	1401	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of C_reactive_protein -LRB- CRP -RRB- in leptin resistance .
2059079	0	C_reactive_protein	29,47	Cytidine_deaminase	0,18	C reactive protein	Cytidine deaminase	1401	978	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Cytidine_deaminase activity , C_reactive_protein , histidine , and erythrocyte sedimentation rate as measures of disease activity in psoriatic_arthritis .
25888123	0	C_reactive_protein	17,35	fibrinogen	37,47	C reactive protein	fibrinogen	1401	2244	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	High sensitivity C_reactive_protein , fibrinogen levels and the onset of major depressive_disorder in post-acute_coronary_syndrome .
25888123	0	C_reactive_protein	17,35	fibrinogen	37,47	C reactive protein	fibrinogen	1401	2244	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	High sensitivity C_reactive_protein , fibrinogen levels and the onset of major depressive_disorder in post-acute_coronary_syndrome .
1351813	0	Ca2	15,18	ATPase	48,54	Ca2	ATPase	760	1769	Gene	Gene	ATPase|amod|START_ENTITY ATPase|dep|END_ENTITY	High affinity , Ca2 + specific ATPase and Na + K -LRB- + -RRB- - ATPase in the gills of a supralittoral crab Leptograpsus variegatus .
2144382	0	Ca2	28,31	ATPase	38,44	Ca2	ATPase	760	1769	Gene	Gene	+|compound|START_ENTITY Reconstruction|nmod|+ Reconstruction|dep|END_ENTITY	-LSB- Reconstruction of purified Ca2 + , Mg2 + - ATPase from the myometrium sarcolemma into liposomes and its catalytic properties -RSB- .
7876199	0	Ca2	38,41	ATPase	92,98	Ca2	ATPase	760	1769	Gene	Gene	+|amod|START_ENTITY efficiency|nmod|+ +|nsubj|efficiency +|nmod|END_ENTITY	Variable stoichiometric efficiency of Ca2 + and Sr2 + transport by the sarcoplasmic reticulum ATPase .
9989931	0	Ca2	82,85	ATPase	87,93	Ca2	ATPase	760	1769	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Effects of various amino_acid 256 mutations on sarcoplasmic/endoplasmic reticulum Ca2 + ATPase function and their role in the cellular adaptive response to thapsigargin .
8864483	0	Ca2	43,46	CA1	80,83	Ca2	CA1	100719293	100720116	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	Extracellular Mg2 + modulates intracellular Ca2 + in acutely isolated hippocampal CA1 pyramidal cells of the guinea-pig .
19793978	0	Ca2	0,3	Ca2	20,23	Ca2	Ca2	760	760	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nummod|+	Ca2 + current versus Ca2 + channel cooperativity of exocytosis .
19793978	0	Ca2	20,23	Ca2	0,3	Ca2	Ca2	760	760	Gene	Gene	START_ENTITY|nummod|+ +|compound|END_ENTITY	Ca2 + current versus Ca2 + channel cooperativity of exocytosis .
2296584	0	Ca2	14,17	Ca2	54,57	Ca2	Ca2	379772(Tax:8355)	379772(Tax:8355)	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Inhibition by Ca2 + of inositol_trisphosphate-mediated Ca2 + liberation : a possible mechanism for oscillatory release of Ca2 + .
2296584	0	Ca2	54,57	Ca2	14,17	Ca2	Ca2	379772(Tax:8355)	379772(Tax:8355)	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Inhibition by Ca2 + of inositol_trisphosphate-mediated Ca2 + liberation : a possible mechanism for oscillatory release of Ca2 + .
26849136	0	Ca2	28,31	Ca2	69,72	Ca2	Ca2	12349(Tax:10090)	12349(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	By Regulating Mitochondrial Ca2 + - Uptake UCP2 Modulates Intracellular Ca2 .
26849136	0	Ca2	69,72	Ca2	28,31	Ca2	Ca2	12349(Tax:10090)	12349(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	By Regulating Mitochondrial Ca2 + - Uptake UCP2 Modulates Intracellular Ca2 .
7531770	0	Ca2	0,3	Ca2	50,53	Ca2	Ca2	100719293	100719293	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Ca2 + inhibition of inositol_trisphosphate-induced Ca2 + release in single smooth muscle cells of guinea-pig small intestine .
7531770	0	Ca2	50,53	Ca2	0,3	Ca2	Ca2	100719293	100719293	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Ca2 + inhibition of inositol_trisphosphate-induced Ca2 + release in single smooth muscle cells of guinea-pig small intestine .
7929156	0	Ca2	16,19	Ca2	73,76	Ca2	Ca2	760	760	Gene	Gene	release|amod|START_ENTITY release|dep|END_ENTITY	Smoothly graded Ca2 + release from inositol_1 ,4,5 - trisphosphate-sensitive Ca2 + stores .
7929156	0	Ca2	73,76	Ca2	16,19	Ca2	Ca2	760	760	Gene	Gene	release|dep|START_ENTITY release|amod|END_ENTITY	Smoothly graded Ca2 + release from inositol_1 ,4,5 - trisphosphate-sensitive Ca2 + stores .
8385232	0	Ca2	42,45	Ca2	54,57	Ca2	Ca2	760	760	Gene	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Control of Ca2 + influx by manipulation of Ca2 + and/or Ca2 + antagonist in cardioplegic_arrest .
8385232	0	Ca2	54,57	Ca2	42,45	Ca2	Ca2	760	760	Gene	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Control of Ca2 + influx by manipulation of Ca2 + and/or Ca2 + antagonist in cardioplegic_arrest .
9277471	0	Ca2	10,13	Ca2	31,34	Ca2	Ca2	54231(Tax:10116)	54231(Tax:10116)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Transient Ca2 + overload alters Ca2 + handling in rat cardiomyocytes : effects on shortening and relaxation .
9277471	0	Ca2	31,34	Ca2	10,13	Ca2	Ca2	54231(Tax:10116)	54231(Tax:10116)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Transient Ca2 + overload alters Ca2 + handling in rat cardiomyocytes : effects on shortening and relaxation .
12468029	0	Ca2	123,126	ERK	34,37	Ca2	ERK	760	5594	Gene	Gene	+|nsubj|START_ENTITY involves|ccomp|+ END_ENTITY|parataxis|involves	Activation of the neuroprotective ERK signaling pathway by fructose-1 ,6 - bisphosphate during hypoxia involves intracellular Ca2 + and phospholipase C .
18478546	0	Ca2	82,85	ERK	101,104	Ca2	ERK	54231(Tax:10116)	24338(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2 + / CaM-dependent ERK activation in cerebral_ischemia .
17705784	0	Ca2	15,18	Fortilin	0,8	Ca2	Fortilin	760	7178	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Fortilin binds Ca2 + and blocks Ca2 + - dependent apoptosis in vivo .
8581971	0	Ca2	29,32	Hg2	11,14	Ca2	Hg2	760	283955	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Effects of Hg2 + on cytosolic Ca2 + in isolated skate hepatocytes .
16894058	0	Ca2	6,9	Nox2	0,4	Ca2	Nox2	12349(Tax:10090)	13058(Tax:10090)	Gene	Gene	play|nsubj|START_ENTITY play|advmod|END_ENTITY	Nox2 , Ca2 + , and protein_kinase_C play a role in angiotensin_II-induced free radical production in nucleus tractus solitarius .
11964231	0	Ca2	0,3	RyR1	19,23	Ca2	RyR1	760	6261	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Ca2 + activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling .
12045220	0	Ca2	54,57	RyR1	0,4	Ca2	RyR1	760	6261	Gene	Gene	provide|iobj|START_ENTITY isoforms|xcomp|provide isoforms|nsubj|END_ENTITY	RyR1 and RyR3 isoforms provide distinct intracellular Ca2 + signals in HEK 293 cells .
22565091	0	Ca2	22,25	STIM1	0,5	Ca2	STIM1	760	6786	Gene	Gene	+|compound|START_ENTITY required|nmod|+ required|nsubjpass|END_ENTITY	STIM1 is required for Ca2 + signaling during mammalian fertilization .
17535744	0	Ca2	7,10	TRPP2	0,5	Ca2	TRPP2	760	5311	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	TRPP2 : Ca2 + - permeable cation channel and more .
19153608	0	Ca2	46,49	TRPP2	0,5	Ca2	TRPP2	760	5311	Gene	Gene	concentration|amod|START_ENTITY regulate|nmod|concentration regulate|nsubj|channels channels|compound|END_ENTITY	TRPP2 channels regulate apoptosis through the Ca2 + concentration in the endoplasmic reticulum .
2166565	0	Ca2	0,3	calbindin_D9k	16,29	Ca2	calbindin D9k	760	795	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Ca2 + binding to calbindin_D9k strongly affects backbone dynamics : measurements of exchange rates of individual amide protons using 1H NMR .
1659415	0	Ca2	42,45	eEF-2	26,31	Ca2	eEF-2	760	1938	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	Increased activity of the eEF-2 specific , Ca2 + and calmodulin_dependent_protein_kinase_III during the S-phase in Ehrlich ascites cells .
8587360	0	Ca2	0,3	endothelin-1	76,88	Ca2	endothelin-1	54231(Tax:10116)	24323(Tax:10116)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	Ca2 + and contractile responses of resistance vessels of WKY rats and SHR to endothelin-1 .
7309712	0	Ca2	41,44	phospholipase_A2	53,69	Ca2	phospholipase A2	760	151056	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	pH dependence of the binding constant of Ca2 + to the phospholipase_A2 of A. halys blomhoffii .
19632983	0	Ca2	4,7	synaptotagmin_1	21,36	Ca2	synaptotagmin 1	760	6857	Gene	Gene	affinity|amod|START_ENTITY affinity|nmod|END_ENTITY	The Ca2 + affinity of synaptotagmin_1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol_4 ,5 - bisphosphate .
18041110	0	Ca2	0,3	thyrotropin-releasing_hormone	18,47	Ca2	thyrotropin-releasing hormone	760	7200	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Ca2 + responses to thyrotropin-releasing_hormone and angiotensin_II : the role of plasma membrane integrity and effect of G11alpha protein overexpression on homologous and heterologous desensitization .
3676777	0	CaBP	71,75	cholecalcin	58,69	CaBP	cholecalcin	29177(Tax:10116)	24249(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The comparative immunocytochemical distribution of 28 kDa cholecalcin -LRB- CaBP -RRB- in the hippocampus of rat , guinea_pig and hedgehog .
4027624	0	CaBP	18,22	cholecalcin	5,16	CaBP	cholecalcin	12309(Tax:10090)	24249(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	28 K cholecalcin -LRB- CaBP -RRB- levels in abnormal cerebella : studies on mutant mice and harmaline - and 3-acetylpyridine-treated rats .
9058200	0	CaBP1	19,24	CK2	53,56	CaBP1	CK2	9478	13000(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of CaBP1 and CaBP2 by protein kinase CK2 .
8477750	0	CaBP2	0,5	ERp72	26,31	CaBP2	ERp72	499298(Tax:10116)	116598(Tax:10116)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity .
18296658	0	CaBP4	34,39	MRG4	52,56	CaBP4	MRG4	73660(Tax:10090)	22248(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction and colocalization of CaBP4 and Unc119 -LRB- MRG4 -RRB- in photoreceptors .
11863852	0	CaF2	149,153	Tm3	141,144	CaF2	Tm3	9337	7170	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Reappearance of fine structure as a probe of lifetime broadening mechanisms in the 4f -LRB- N -RRB- _ -- > _ 4f -LRB- N-1 -RRB- 5d excitation spectra of Tb3 + , Er3 + , and Tm3 + in CaF2 and LiYF4 .
7733887	0	CaLB	71,75	p120_GAP	91,99	CaLB	p120 GAP	793	5921	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Mutation-deletion analysis of a Ca -LRB- 2 + -RRB- - dependent phospholipid binding -LRB- CaLB -RRB- domain within p120_GAP , a GTPase-activating protein for p21_ras .
21896713	0	CaMK	34,38	calmodulin-dependent_kinase	5,32	CaMK	calmodulin-dependent kinase	814	814	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Ca2 + / calmodulin-dependent_kinase -LRB- CaMK -RRB- signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy .
18588881	0	CaMK-II	123,130	Flightless-I	0,12	CaMK-II	Flightless-I	818	2314	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Flightless-I , a gelsolin family member and transcriptional regulator , preferentially binds directly to activated cytosolic CaMK-II .
23463649	0	CaMK-II	79,86	focal_adhesion_kinase	16,37	CaMK-II	focal adhesion kinase	12325(Tax:10090)	14083(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Cadmium affects focal_adhesion_kinase -LRB- FAK -RRB- in mesangial cells : involvement of CaMK-II and the actin cytoskeleton .
21896713	0	CaMKI	54,59	calmodulin-dependent_kinase	5,32	CaMKI	calmodulin-dependent kinase	8536	814	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Ca2 + / calmodulin-dependent_kinase -LRB- CaMK -RRB- signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy .
15629441	0	CaMKII	0,6	ASK1	17,21	CaMKII	ASK1	818	4217	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy .
23504235	0	CaMKII	0,6	ASK1	17,21	CaMKII	ASK1	818	4217	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CaMKII activates ASK1 to induce apoptosis of spinal astrocytes under oxygen-glucose deprivation .
21513986	0	CaMKII	0,6	Bcl10	15,20	CaMKII	Bcl10	818	8915	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	CaMKII targets Bcl10 in T-cell receptor induced activation of NF-kB .
21768120	0	CaMKII	103,109	GluN2B	171,177	CaMKII	GluN2B	818	2904	Gene	Gene	II|appos|START_ENTITY subunit|nsubj|II subunit|dobj|END_ENTITY	Nucleotides and phosphorylation bi-directionally modulate Ca2 + / calmodulin-dependent protein kinase II -LRB- CaMKII -RRB- binding to the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit GluN2B .
22234183	0	CaMKII	0,6	GluN2B	18,24	CaMKII	GluN2B	108058(Tax:10090)	14812(Tax:10090)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	CaMKII binding to GluN2B is critical during memory consolidation .
23478024	0	CaMKII	10,16	GluN2B	25,31	CaMKII	GluN2B	818	2904	Gene	Gene	couples|nsubj|START_ENTITY couples|ccomp|kinase kinase|nsubj|END_ENTITY	Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors .
24056996	0	CaMKII	22,28	GluN2B	101,107	CaMKII	GluN2B	818	2904	Gene	Gene	activity|nmod|START_ENTITY required|nsubjpass|activity required|nmod|END_ENTITY	Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B .
24796865	0	CaMKII	0,6	GluN2B	18,24	CaMKII	GluN2B	818	2904	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents .
25187880	0	CaMKII	0,6	GluN2B	18,24	CaMKII	GluN2B	108058(Tax:10090)	14812(Tax:10090)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	CaMKII binding to GluN2B is important for massed spatial learning in the Morris water maze .
17023142	0	CaMKII	43,49	PITK	35,39	CaMKII	PITK	818	23243	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dual kinase-mediated regulation of PITK by CaMKII and GSK3 .
22158709	0	CaMKII	14,20	RyR2	40,44	CaMKII	RyR2	12325(Tax:10090)	20191(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial_fibrillation in FKBP12 .6 knockout mice .
23246599	0	CaMKII	14,20	RyR2	40,44	CaMKII	RyR2	12325(Tax:10090)	20191(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular_arrhythmias in mice with Duchenne_muscular_dystrophy .
26080362	0	CaMKII	0,6	RyR2	42,46	CaMKII	RyR2	12325(Tax:10090)	20191(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|phosphorylation phosphorylation|amod|END_ENTITY	CaMKII mediates b-adrenergic effects on RyR2 phosphorylation and SR Ca -LRB- 2 + -RRB- leak and the pathophysiological response to chronic b-adrenergic stimulation .
20353560	0	CaMKII	119,125	VEGF	111,115	CaMKII	VEGF	818	7422	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions ; significant reduction of VEGF by CaMKII inhibitor .
24117889	0	CaMKII	0,6	b-catenin	42,51	CaMKII	b-catenin	818	1499	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	CaMKII represses transcriptionally active b-catenin to mediate acute ethanol neurodegeneration and can phosphorylate b-catenin .
22270398	0	CaMKII	34,40	cofilin	14,21	CaMKII	cofilin	818	1072	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of cofilin activity by CaMKII and calcineurin .
24336150	0	CaMKII	0,6	neuroligin-1	26,38	CaMKII	neuroligin-1	818	22871	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses .
18381242	0	CaMKIV	15,21	BDNF	0,4	CaMKIV	BDNF	814	627	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth .
26227473	0	CaMKKb	49,55	AMPK	29,33	CaMKKb	AMPK	10645	5563	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Proteasome inhibitors induce AMPK activation via CaMKKb in human breast_cancer cells .
15896474	0	CaMK_II	191,198	CaMK_II	70,77	CaMK II	CaMK II	12325(Tax:10090)	12325(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|appos|END_ENTITY	Kainic_acid -LRB- KA -RRB- - induced Ca2 + / calmodulin-dependent_protein_kinase_II -LRB- CaMK_II -RRB- expression in the neurons , astrocytes and microglia of the mouse hippocampal CA3 region , and the phosphorylated CaMK_II only in the hippocampal neurons .
15896474	0	CaMK_II	70,77	CaMK_II	191,198	CaMK II	CaMK II	12325(Tax:10090)	12325(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dep|expression	Kainic_acid -LRB- KA -RRB- - induced Ca2 + / calmodulin-dependent_protein_kinase_II -LRB- CaMK_II -RRB- expression in the neurons , astrocytes and microglia of the mouse hippocampal CA3 region , and the phosphorylated CaMK_II only in the hippocampal neurons .
21689744	0	CaMK_IV	0,7	prohibitin_2	23,35	CaMK IV	prohibitin 2	12326(Tax:10090)	12034(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	CaMK_IV phosphorylates prohibitin_2 and regulates prohibitin_2-mediated repression of MEF2 transcription .
12580936	0	CaR	134,137	calcium-sensing_receptor	108,132	CaR	calcium-sensing receptor	846	846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two Italian kindreds with familial_hypocalciuric_hypercalcaemia caused by loss-of-function mutations in the calcium-sensing_receptor -LRB- CaR -RRB- gene : functional characterization of a novel CaR missense mutation .
26052899	0	CaSR	115,119	Calcium-Sensing_Receptor	89,113	CaSR	Calcium-Sensing Receptor	12374(Tax:10090)	12374(Tax:10090)	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	The Calcilytic Agent NPS_2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing_Receptor -LRB- CaSR -RRB- Mutation : Relevance to Autosomal Dominant Hypocalcemia Type 1 -LRB- ADH1 -RRB- .
24763815	0	CaSR	103,107	Calcium_Sensing_Receptor	77,101	CaSR	Calcium Sensing Receptor	846	846	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Neonatal Severe Hyperparathyroidism due to Compound Heterozygous Mutation of Calcium_Sensing_Receptor -LRB- CaSR -RRB- Gene Presenting as Encephalopathy .
22373575	0	CaSR	61,65	Claudin-14	0,10	CaSR	Claudin-14	846	23562	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Claudin-14 regulates renal Ca ____ transport in response to CaSR signalling via a novel microRNA pathway .
18703641	0	CaSR	0,4	Wnt5a	29,34	CaSR	Wnt5a	846	7474	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia .
19003284	0	CaSR	121,125	calcium-sensing_receptor	95,119	CaSR	calcium-sensing receptor	24247(Tax:10116)	24247(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tissue specific expression and differential regulation by 1alpha,25-dihydroxyvitamin _ D3 of the calcium-sensing_receptor -LRB- CaSR -RRB- gene in rat kidney , intestine , and calvaria .
23856260	0	CaSR	95,99	calcium-sensing_receptor	69,93	CaSR	calcium-sensing receptor	846	846	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The CASR gene : alternative splicing and transcriptional control , and calcium-sensing_receptor -LRB- CaSR -RRB- protein : structure and ligand binding sites .
25500736	0	CaSR	53,57	calcium-sensing_receptor	27,51	CaSR	calcium-sensing receptor	12374(Tax:10090)	12374(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	pH-sensitive expression of calcium-sensing_receptor -LRB- CaSR -RRB- in type-B intercalated cells of the cortical_collecting_ducts -LRB- CCD -RRB- in mouse kidney .
17172641	0	Cabin1	0,6	MEF2	17,21	Cabin1	MEF2	23523	4205	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase , SUV39H1 .
12700764	0	Cabin1	62,68	myocyte_enhancer_factor-2	72,97	Cabin1	myocyte enhancer factor-2	23523	4205	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte_enhancer_factor-2 .
11585773	0	Cables	0,6	Wee1	52,56	Cables	Wee1	91768	7465	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1 , inhibits cell growth , and is lost in many human colon_and_squamous_cancers .
20559324	0	Cables1	0,7	p63	17,20	Cables1	p63	63955(Tax:10090)	22061(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress .
18596967	0	Cacna1f	36,43	nob2	44,48	Cacna1f	nob2	54652(Tax:10090)	54652(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Modified Ca -LRB- v -RRB- 1.4 expression in the Cacna1f -LRB- nob2 -RRB- mouse due to alternative splicing of an ETn inserted in exon 2 .
11756448	0	Cacna2d2	22,30	ducky	4,9	Cacna2d2	ducky	56808(Tax:10090)	56808(Tax:10090)	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2_delta-2 protein with abnormal function .
24999833	0	Cactin	7,13	CACN-1	0,6	Cactin	CACN-1	175066(Tax:6239)	175066(Tax:6239)	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|appos|plays	CACN-1 / Cactin plays a role in Wnt signaling in C. _ elegans .
16289137	0	CacyBP	65,71	calcyclin-binding_protein	38,63	CacyBP	calcyclin-binding protein	12301(Tax:10090)	12301(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Expression and hormonal regulation of calcyclin-binding_protein -LRB- CacyBP -RRB- in the mouse uterus during early pregnancy .
15708564	0	Cad99C	9,15	Hedgehog	32,40	Cad99C	Hedgehog	43528(Tax:7227)	42737(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cadherin Cad99C is regulated by Hedgehog signaling in Drosophila .
25236597	0	Cad99C	76,82	Myosin_VIIA	0,11	Cad99C	Myosin VIIA	43528(Tax:7227)	34882(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Myosin_VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis .
18809931	0	Cadherin	23,31	Dachsous	14,22	Cadherin	Dachsous	37386(Tax:7227)	33245(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation .
18302981	0	Cadherin-11	0,11	FGF_receptor	31,43	Cadherin-11	FGF receptor	1009	2263	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cadherin-11 interacts with the FGF_receptor and induces neurite outgrowth through associated downstream signalling .
25794160	0	Cadherin-11	64,75	c-JUN	37,42	Cadherin-11	c-JUN	1009	3725	Gene	Gene	Expression|compound|START_ENTITY Expression|amod|END_ENTITY	AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion .
15023537	0	Cadherin-related_neuronal_receptor_1	0,36	beta1_integrin	76,90	Cadherin-related neuronal receptor 1	beta1 integrin	56117	3688	Gene	Gene	has|nsubj|START_ENTITY has|dobj|activity activity|nmod|END_ENTITY	Cadherin-related_neuronal_receptor_1 -LRB- CNR1 -RRB- has cell adhesion activity with beta1_integrin mediated through the RGD site of CNR1 .
24940649	0	Cadherin_11	0,11	N-Cadherin	39,49	Cadherin 11	N-Cadherin	1009	1000	Gene	Gene	START_ENTITY|appos|Expression Expression|compound|END_ENTITY	Cadherin_11 , a miR-675 Target , Induces N-Cadherin Expression and Epithelial-Mesenchymal Transition in Melasma .
25331796	0	Cadherin_17	40,51	liver-intestine_cadherin	14,38	Cadherin 17	liver-intestine cadherin	1015	1015	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of liver-intestine_cadherin -LRB- Cadherin_17 -RRB- expression , ERK phosphorylation and WNT signaling in EPHB6 receptor-expressing MDA-MB-231 cells .
24069422	0	Cadherin_6	0,10	TGF-b	36,41	Cadherin 6	TGF-b	1004	7040	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cadherin_6 is a new RUNX2 target in TGF-b signalling pathway .
21570500	0	Caf-1	42,47	p150	4,8	Caf-1	p150	27221(Tax:10090)	13191(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1 .
24462875	0	CagA	0,4	IgA1	105,109	CagA	IgA1	6279	3493	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|nmod|END_ENTITY	CagA , a major virulence factor of Helicobacter_pylori , promotes the production and underglycosylation of IgA1 in DAKIKI cells .
25015565	0	CagA	56,60	RBP2	20,24	CagA	RBP2	6279	5948	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells .
15940789	0	CagA	25,29	cagA	14,18	CagA	cagA	6279	6279	Gene	Gene	protein|compound|START_ENTITY gene|appos|protein gene|compound|END_ENTITY	-LSB- Detection of cagA gene , CagA protein in Helicobacter_pylori isolates and its antibody in serum of patients with gastric_diseases by a recombinant protein CagA 1 -RSB- .
8980526	0	Cah1	53,57	carbonic_anhydrase	28,46	Cah1	carbonic anhydrase	5717875(Tax:3055)	5717875(Tax:3055)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Circadian expression of the carbonic_anhydrase gene , Cah1 , in Chlamydomonas_reinhardtii .
16362371	0	Cak1	7,11	Ssu72	73,78	Cak1	Ssu72	850515(Tax:4932)	855499(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1 .
14612412	0	Cak1p	26,31	Ime2p	65,70	Cak1p	Ime2p	850515(Tax:4932)	853338(Tax:4932)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	The Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p .
24958846	0	CalDAG-GEFI	6,17	RASGRP2	24,31	CalDAG-GEFI	RASGRP2	10235	10235	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human CalDAG-GEFI gene -LRB- RASGRP2 -RRB- mutation affects platelet function and causes severe bleeding .
21480213	0	CalDAG-GEFI	20,31	Rap1a	0,5	CalDAG-GEFI	Rap1a	19395(Tax:10090)	109905(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Rap1a activation by CalDAG-GEFI and p38_MAPK is involved in E-selectin-dependent slow leukocyte rolling .
11278453	0	CalDAG-GEF_I	57,69	Rap1	18,22	CalDAG-GEF I	Rap1	19395(Tax:10090)	109905(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Activation of the Rap1 guanine_nucleotide exchange gene , CalDAG-GEF_I , in BXH-2 murine myeloid_leukemia .
21256111	0	Calcineurin_B	0,13	hypoxia-inducible_factor-1a	83,110	Calcineurin B	hypoxia-inducible factor-1a	5534	3091	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Calcineurin_B subunit interacts with proteasome_subunit_alpha_type_7 and represses hypoxia-inducible_factor-1a activity via the proteasome pathway .
21256111	0	Calcineurin_B	0,13	proteasome_subunit_alpha_type_7	37,68	Calcineurin B	proteasome subunit alpha type 7	5534	5688	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Calcineurin_B subunit interacts with proteasome_subunit_alpha_type_7 and represses hypoxia-inducible_factor-1a activity via the proteasome pathway .
3628548	0	Calcitonin	0,10	angiotensin_II	91,105	Calcitonin	angiotensin II	24241(Tax:10116)	24179(Tax:10116)	Gene	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Calcitonin effect on the dipsogenic response to intra-cerebroventricular administration of angiotensin_II .
954281	0	Calcitonin	0,10	parathyroid_hormone	71,90	Calcitonin	parathyroid hormone	24241(Tax:10116)	24694(Tax:10116)	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Calcitonin and the bone fluid compartment : effect of calcitonin and/or parathyroid_hormone on plasma radiocalcium changes .
21153249	0	Calcitonin	0,10	prolactin	20,29	Calcitonin	prolactin	24241(Tax:10116)	24683(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Calcitonin inhibits prolactin gene transcription in rat pituitary cells .
25860809	0	Calcitonin_Gene-Related_Peptide	0,31	CGRP	33,37	Calcitonin Gene-Related Peptide	CGRP	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	Receptors|amod|START_ENTITY Receptors|appos|END_ENTITY	Calcitonin_Gene-Related_Peptide -LRB- CGRP -RRB- Receptors Are Important to Maintain Cerebrovascular Reactivity in Chronic Hypertension .
20881236	0	Calcitonin_gene-related_peptide	0,31	AMP-activated_protein_kinase	58,86	Calcitonin gene-related peptide	AMP-activated protein kinase	796	5563	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|angiogenesis angiogenesis|nmod|END_ENTITY	Calcitonin_gene-related_peptide promotes angiogenesis via AMP-activated_protein_kinase .
23708553	0	Calcitonin_gene-related_peptide	0,31	BMP-2	43,48	Calcitonin gene-related peptide	BMP-2	796	650	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Calcitonin_gene-related_peptide stimulates BMP-2 expression and the differentiation of human osteoblast-like cells in vitro .
10209067	0	Calcitonin_gene-related_peptide	0,31	CGRP	33,37	Calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- increases intracellular free Ca2 + concentrations but not cyclic_AMP formation in CGRP_receptor-positive osteosarcoma cells -LRB- OHS-4 -RRB- .
11035643	0	Calcitonin_gene-related_peptide	0,31	CGRP	33,37	Calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- expression in the human neonatal paravertebral ganglia .
15237096	0	Calcitonin_gene-related_peptide	0,31	CGRP	33,37	Calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonists : blockers of neuronal transmission in migraine .
20433208	0	Calcitonin_gene-related_peptide	0,31	CGRP	33,37	Calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists in the treatment of migraine .
2177866	0	Calcitonin_gene-related_peptide	0,31	CGRP	33,37	Calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors are linked to cyclic_adenosine_monophosphate production in SK-N-MC human neuroblastoma cells .
8535845	0	Calcitonin_gene-related_peptide	0,31	CGRP	33,37	Calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Calcitonin_gene-related_peptide -LRB- CGRP -RRB- content and CGRP receptor binding sites in discrete forebrain regions of alcohol-preferring vs. - nonpreferring rats , and high_alcohol-drinking vs. low alcohol-drinking rats .
17488278	0	Calcitonin_gene-related_peptide	0,31	ColQ	99,103	Calcitonin gene-related peptide	ColQ	796	8292	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Calcitonin_gene-related_peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle : a distinction in driving two different promoters between fast - and slow-twitch muscle fibers .
14962494	0	Calcitonin_gene-related_peptide	0,31	IL-6	98,102	Calcitonin gene-related peptide	IL-6	796	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Calcitonin_gene-related_peptide indirectly inhibits IL-7 responses in pre-B cells by induction of IL-6 and TNF-alpha in bone marrow .
7671321	0	Calcitonin_gene-related_peptide	0,31	IL-6	58,62	Calcitonin gene-related peptide	IL-6	796	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Calcitonin_gene-related_peptide enhances cytokine-induced IL-6 production by fibroblasts .
10754330	0	Calcitonin_gene-related_peptide	0,31	IL-8	40,44	Calcitonin gene-related peptide	IL-8	796	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|compound|END_ENTITY	Calcitonin_gene-related_peptide induces IL-8 synthesis in human corneal epithelial cells .
17064360	0	Calcitonin_gene-related_peptide	0,31	brain-derived_neurotrophic_factor	59,92	Calcitonin gene-related peptide	brain-derived neurotrophic factor	24241(Tax:10116)	24225(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|release release|nmod|END_ENTITY	Calcitonin_gene-related_peptide enhances release of native brain-derived_neurotrophic_factor from trigeminal ganglion neurons .
25403360	0	Calcitonin_gene-related_peptide	0,31	glial_cell-line_derived_neurotrophic_factor	46,89	Calcitonin gene-related peptide	glial cell-line derived neurotrophic factor	24241(Tax:10116)	25453(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Calcitonin_gene-related_peptide regulation of glial_cell-line_derived_neurotrophic_factor in differentiated rat myotubes .
17007741	0	Calcitonin_gene-related_peptide	0,31	interleukin-8	67,80	Calcitonin gene-related peptide	interleukin-8	796	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Calcitonin_gene-related_peptide inhibits interleukin-1beta-induced interleukin-8 secretion in human type II alveolar epithelial cells .
1383217	0	Calcitonin_gene-related_peptide	0,31	interleukin_2	41,54	Calcitonin gene-related peptide	interleukin 2	12310(Tax:10090)	16183(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Calcitonin_gene-related_peptide inhibits interleukin_2 production by murine T lymphocytes .
16597919	0	Calcitonin_gene-related_peptide	0,31	monocyte_chemoattractant_protein-1	78,112	Calcitonin gene-related peptide	monocyte chemoattractant protein-1	796	6347	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Calcitonin_gene-related_peptide inhibits interleukin-1beta-induced endogenous monocyte_chemoattractant_protein-1 secretion in type II alveolar epithelial cells .
2841355	0	Calcitonin_gene-related_peptide	0,31	renin	51,56	Calcitonin gene-related peptide	renin	24241(Tax:10116)	24715(Tax:10116)	Gene	Gene	stimulator|nsubj|START_ENTITY stimulator|nmod|secretion secretion|compound|END_ENTITY	Calcitonin_gene-related_peptide is a stimulator of renin secretion .
16904202	0	Calcitonin_gene-related_peptide	0,31	vascular_endothelial_growth_factor	60,94	Calcitonin gene-related peptide	vascular endothelial growth factor	796	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Calcitonin_gene-related_peptide regulates the expression of vascular_endothelial_growth_factor in human HaCaT keratinocytes by activation of ERK1/2 MAPK .
26052899	0	Calcium-Sensing_Receptor	89,113	CaSR	115,119	Calcium-Sensing Receptor	CaSR	12374(Tax:10090)	12374(Tax:10090)	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	The Calcilytic Agent NPS_2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing_Receptor -LRB- CaSR -RRB- Mutation : Relevance to Autosomal Dominant Hypocalcemia Type 1 -LRB- ADH1 -RRB- .
1656060	0	Calcium-activated_neutral_proteinase	0,36	CANP	38,42	Calcium-activated neutral proteinase	CANP	823	823	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Calcium-activated_neutral_proteinase -LRB- CANP ; calpain -RRB- activity in Schwann cells : immunofluorescence localization and compartmentation of mu - and mCANP .
12810819	0	Calcium-independent_phospholipase_A2	0,36	CREB	46,50	Calcium-independent phospholipase A2	CREB	282438(Tax:9913)	281713(Tax:9913)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Calcium-independent_phospholipase_A2 mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells .
20164288	0	Calcium-sensing_receptor	0,24	CASR	26,30	Calcium-sensing receptor	CASR	846	846	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Calcium-sensing_receptor -LRB- CASR -RRB- mutations in hypercalcemic states : studies from a single endocrine clinic over three years .
22648622	0	Calcium-sensing_receptor	0,24	CCK	58,61	Calcium-sensing receptor	CCK	846	885	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|secretion secretion|compound|END_ENTITY	Calcium-sensing_receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells .
12700162	0	Calcium-sensing_receptor	0,24	PTHrP	36,41	Calcium-sensing receptor	PTHrP	846	5744	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Calcium-sensing_receptor stimulates PTHrP release by pathways dependent on PKC , p38 MAPK , JNK , and ERK1/2 in H-500 cells .
23913765	0	Calcium-sensing_receptor	0,24	TRPV1	120,125	Calcium-sensing receptor	TRPV1	24247(Tax:10116)	83810(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	Calcium-sensing_receptor in rat vagal bronchopulmonary sensory neurons regulates the function of the capsaicin receptor TRPV1 .
18032798	0	Calcium-sensing_receptor	0,24	aquaporin-2	48,59	Calcium-sensing receptor	aquaporin-2	12374(Tax:10090)	11827(Tax:10090)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Calcium-sensing_receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism .
9039332	0	Calcium-sensing_receptor	0,24	familial_hypocalciuric_hypercalcaemia	38,75	Calcium-sensing receptor	familial hypocalciuric hypercalcaemia	846	846	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Calcium-sensing_receptor mutations in familial_hypocalciuric_hypercalcaemia with recurrent pancreatitis .
19257819	0	Calcium-sensing_receptor	0,24	glial_cells_missing-2	52,73	Calcium-sensing receptor	glial cells missing-2	846	9247	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Calcium-sensing_receptor expression is regulated by glial_cells_missing-2 in human parathyroid cells .
26546674	0	Calcium_Release-Activated_Calcium_Modulator_1	88,133	STIM1	55,60	Calcium Release-Activated Calcium Modulator 1	STIM1	84876	6786	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
26546674	0	Calcium_Release-Activated_Calcium_Modulator_1	88,133	Stromal_Interaction_Molecule_1	23,53	Calcium Release-Activated Calcium Modulator 1	Stromal Interaction Molecule 1	84876	6786	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
24763815	0	Calcium_Sensing_Receptor	77,101	CaSR	103,107	Calcium Sensing Receptor	CaSR	846	846	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Neonatal Severe Hyperparathyroidism due to Compound Heterozygous Mutation of Calcium_Sensing_Receptor -LRB- CaSR -RRB- Gene Presenting as Encephalopathy .
12730726	0	Calcr	0,5	calcitonin_receptor	40,59	Calcr	calcitonin receptor	12311(Tax:10090)	12311(Tax:10090)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Calcr , a brain-specific imprinted mouse calcitonin_receptor gene in the imprinted cluster of the proximal region of chromosome 6 .
22650988	0	Calcyon	0,7	NEEP21	30,36	Calcyon	NEEP21	68566(Tax:10090)	27065	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Calcyon , a mammalian specific NEEP21 family member , interacts with adaptor protein complex 3 -LRB- AP-3 -RRB- and regulates targeting of AP-3 cargoes .
18784990	0	Calgranulin_B	0,13	S100A9	15,21	Calgranulin B	S100A9	6280	6280	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Calgranulin_B -LRB- S100A9 -RRB- levels in bronchoalveolar lavage fluid of patients with interstitial_lung_diseases .
26391397	0	Calmodulin	72,82	Akt	121,124	Calmodulin	Akt	808	207	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Structural and Biophysical Characterization of the Interactions Between Calmodulin and the Pleckstrin Homology Domain of Akt .
21185879	0	Calmodulin	0,10	HER2	17,21	Calmodulin	HER2	808	2064	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|HER2 HER2|compound|END_ENTITY	Calmodulin binds HER2 and modulates HER2 signaling .
21185879	0	Calmodulin	0,10	HER2	36,40	Calmodulin	HER2	808	2064	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Calmodulin binds HER2 and modulates HER2 signaling .
1790714	0	Calmodulin	0,10	MIP26	78,83	Calmodulin	MIP26	808	4284	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26 .
2487274	0	Calmodulin	0,10	MIP26	76,81	Calmodulin	MIP26	808	4284	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26 .
26421717	0	Calmodulin	0,10	NCX1	55,59	Calmodulin	NCX1	808	6546	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity .
7556088	0	Calmodulin	0,10	NinaC	33,38	Calmodulin	NinaC	36329(Tax:7227)	34012(Tax:7227)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Calmodulin binding to Drosophila NinaC required for termination of phototransduction .
21558796	0	Calmodulin	0,10	Sec61	50,55	Calmodulin	Sec61	852406(Tax:4932)	851095(Tax:4932)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates .
21506119	0	Calmodulin	0,10	androgen_receptor	20,37	Calmodulin	androgen receptor	808	367	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Calmodulin protects androgen_receptor from calpain-mediated breakdown in prostate_cancer cells .
18524472	0	Calmodulin	0,10	estrogen_receptor_alpha	40,63	Calmodulin	estrogen receptor alpha	808	2099	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Calmodulin , a regulatory partner of the estrogen_receptor_alpha in breast_cancer cells .
20523736	0	Calmodulin	0,10	hEAG1	28,33	Calmodulin	hEAG1	808	3756	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Calmodulin interaction with hEAG1 visualized by FRET microscopy .
19393622	0	Calmodulin-dependent_kinase_II	0,30	Dlx5	41,45	Calmodulin-dependent kinase II	Dlx5	818	1749	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Calmodulin-dependent_kinase_II regulates Dlx5 during osteoblast differentiation .
8187553	0	Calna2	95,101	A_beta	78,84	Calna2	A beta	24675(Tax:10116)	54226(Tax:10116)	Gene	Gene	subunits|appos|START_ENTITY subunits|compound|END_ENTITY	Chromosomal assignments of the genes for the calcineurin A alpha -LRB- Calna1 -RRB- and A_beta subunits -LRB- Calna2 -RRB- in the rat .
25170080	0	Calnexin	120,128	ATP-binding_Cassette_Transporter_A1	39,74	Calnexin	ATP-binding Cassette Transporter A1	821	19	Gene	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	HIV-1 Protein Nef Inhibits Activity of ATP-binding_Cassette_Transporter_A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin .
25170080	0	Calnexin	120,128	Nef	14,17	Calnexin	Nef	821	6285	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	HIV-1 Protein Nef Inhibits Activity of ATP-binding_Cassette_Transporter_A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin .
25586181	0	Calnexin	35,43	PTP1B	81,86	Calnexin	PTP1B	821	5770	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	UBC9-dependent Association between Calnexin and Protein_Tyrosine_Phosphatase_1B -LRB- PTP1B -RRB- at the Endoplasmic Reticulum .
10698171	0	Calnexin	0,8	thyroperoxidase	43,58	Calnexin	thyroperoxidase	821	7173	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Calnexin and calreticulin binding to human thyroperoxidase is required for its first folding step -LRB- s -RRB- but is not sufficient to promote efficient cell surface expression .
9359841	0	Calnexin	0,8	tissue-type_plasminogen_activator	53,86	Calnexin	tissue-type plasminogen activator	821	5327	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	Calnexin and calreticulin bind to enzymically active tissue-type_plasminogen_activator during biosynthesis and are not required for folding to the native conformation .
19497050	0	Calnuc	0,6	LRP9	16,20	Calnuc	LRP9	4924	6653	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Calnuc binds to LRP9 and affects its endosomal sorting .
17348862	0	Calnuc	0,6	beta-amyloid_precursor_protein	28,58	Calnuc	beta-amyloid precursor protein	4924	351	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Calnuc binds to Alzheimer 's beta-amyloid_precursor_protein and affects its biogenesis .
7823949	0	CalpA	0,5	calpain	20,27	CalpA	calpain	37232(Tax:7227)	37232(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	CalpA , a Drosophila calpain homolog specifically expressed in a small set of nerve , midgut , and blood cells .
14612448	0	Calpain-1	0,9	Bax	20,23	Calpain-1	Bax	823	581	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis .
14612448	0	Calpain-1	0,9	caspase-3	54,63	Calpain-1	caspase-3	823	836	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis .
21406564	0	Calpain-6	0,9	Rac1	56,60	Calpain-6	Rac1	12338(Tax:10090)	19353(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Calpain-6 , a microtubule-stabilizing protein , regulates Rac1 activity and cell motility through interaction with GEF-H1 .
21681744	0	Calpain-6	0,9	endothelin-1	16,28	Calpain-6	endothelin-1	827	1906	Gene	Gene	factor|nsubj|START_ENTITY factor|amod|END_ENTITY	Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma .
21616915	0	Calpain-7	0,9	CHMP1B	19,25	Calpain-7	CHMP1B	23473	57132	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Calpain-7 binds to CHMP1B at its second a-helical region and forms a ternary complex with IST1 .
22377768	0	Calpain4	0,8	HER2	39,43	Calpain4	HER2	826	2064	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Calpain4 is required for activation of HER2 in breast_cancer cells exposed to trastuzumab and its suppression decreases survival and enhances response .
26375440	0	Calpain6	68,76	miR-449a	0,8	Calpain6	miR-449a	827	554213	Gene	Gene	down-regulation|nmod|START_ENTITY promotes|nmod|down-regulation promotes|nsubj|END_ENTITY	miR-449a promotes liver_cancer cell apoptosis by down-regulation of Calpain6 and POU2F1 .
15956473	0	Calpain_3	0,9	p94	10,13	Calpain 3	p94	12335(Tax:10090)	12335(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|END_ENTITY	Calpain_3 / p94 is not involved in postmortem proteolysis .
23951044	0	Calpastatin	0,11	CAST	18,22	Calpastatin	CAST	831	831	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Calpastatin gene -LRB- CAST -RRB- is not associated with late onset sporadic_Parkinson 's _ disease in the Han Chinese population .
21338355	0	Calpastatin	0,11	p25	106,109	Calpastatin	p25	12380(Tax:10090)	12569(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Calpastatin , an endogenous calpain-inhibitor protein , regulates the cleavage of the Cdk5 activator p35 to p25 .
10618645	0	Calphostin_C	0,12	AP1	21,24	Calphostin C	AP1	10367	3725	Gene	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Calphostin_C induces AP1 synthesis and AP1-dependent c-jun transactivation in normal human chondrocytes independent of protein_kinase_C-alpha inhibition : possible role for c-jun N-terminal kinase .
12242300	0	Calreticulin	0,12	C/EBPalpha	28,38	Calreticulin	C/EBPalpha	811	1050	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Calreticulin interacts with C/EBPalpha and C/EBPbeta mRNAs and represses translation of C/EBP proteins .
8062452	0	Calreticulin	0,12	C1q	65,68	Calreticulin	C1q	811	712	Gene	Gene	released|nsubjpass|START_ENTITY released|nmod|neutrophils neutrophils|nmod|END_ENTITY	Calreticulin is released from activated neutrophils and binds to C1q and mannan-binding protein .
25323779	0	Calreticulin	43,55	CALR	62,66	Calreticulin	CALR	811	811	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Frequency and Molecular Characteristics of Calreticulin Gene -LRB- CALR -RRB- Mutations in Patients with JAK2 _ - Negative_Myeloproliferative_Neoplasms .
16943193	0	Calreticulin	0,12	E-cadherin	23,33	Calreticulin	E-cadherin	811	999	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug .
26583143	0	Calreticulin	0,12	Fas_Ligand	22,32	Calreticulin	Fas Ligand	811	356	Gene	Gene	Binds|nsubj|START_ENTITY Binds|nmod|END_ENTITY	Calreticulin Binds to Fas_Ligand and Inhibits Neuronal Cell Apoptosis Induced by Ischemia-Reperfusion_Injury .
11378243	0	Calreticulin	0,12	beta-amyloid_precursor_protein	56,86	Calreticulin	beta-amyloid precursor protein	811	351	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Calreticulin functions as a molecular chaperone for the beta-amyloid_precursor_protein .
24593306	0	Calreticulin	0,12	fucosyltransferase_1	55,75	Calreticulin	fucosyltransferase 1	811	2523	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Calreticulin activates b1 integrin via fucosylation by fucosyltransferase_1 in J82 human bladder_cancer cells .
17563366	0	Calreticulin	0,12	insulin_receptor	43,59	Calreticulin	insulin receptor	811	3643	Gene	Gene	stabilize|nsubj|START_ENTITY stabilize|dobj|END_ENTITY	Calreticulin and Hsp90 stabilize the human insulin_receptor and promote its mobility in the endoplasmic reticulum .
18840478	0	Calreticulin	0,12	insulin_receptor	23,39	Calreticulin	insulin receptor	12317(Tax:10090)	16337(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Calreticulin regulates insulin_receptor expression and its downstream PI3 Kinase/Akt signalling pathway .
7876246	0	Calreticulin	0,12	myeloperoxidase	71,86	Calreticulin	myeloperoxidase	811	4353	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase .
24103856	0	Calreticulin	0,12	thioredoxin	53,64	Calreticulin	thioredoxin	811	7295	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nmod|END_ENTITY	Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular_endothelial_growth_factor in peripheral blood mononuclear cells .
9988700	0	Calreticulin	0,12	thyroid_transcription_factor-1	54,84	Calreticulin	thyroid transcription factor-1	811	7080	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Calreticulin enhances the transcriptional activity of thyroid_transcription_factor-1 by binding to its homeodomain .
18025526	0	Calsarcin-1	0,11	angiotensin-II	29,43	Calsarcin-1	angiotensin-II	59006(Tax:10090)	11606(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Calsarcin-1 protects against angiotensin-II induced cardiac_hypertrophy .
18562801	0	Calumenin	0,9	SERCA2	25,31	Calumenin	SERCA2	64366(Tax:10116)	29693(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Calumenin interacts with SERCA2 in rat cardiac sarcoplasmic reticulum .
23680840	0	Camk4	54,59	Nurr1	111,116	Camk4	Nurr1	814	4929	Gene	Gene	expression|nmod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	Late maternal_hypothyroidism alters the expression of Camk4 in neocortical subplate neurons : a comparison with Nurr1 labeling .
12562514	0	Cannabinoid	0,11	CB1	12,15	Cannabinoid	CB1	12801(Tax:10090)	12801(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Cannabinoid CB1 receptor knockout mice exhibit markedly reduced voluntary_alcohol_consumption and lack alcohol-induced dopamine release in the nucleus accumbens .
19033531	0	Cannabinoid-1	0,13	CB1	15,18	Cannabinoid-1	CB1	12801(Tax:10090)	12801(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Cannabinoid-1 -LRB- CB1 -RRB- receptors regulate colonic propulsion by acting at motor neurons within the ascending motor pathways in mouse colon .
15592865	0	Cap-G	46,51	CID	110,113	Cap-G	CID	36440(Tax:7227)	36495(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Drosophila_melanogaster condensin subunit Cap-G interacts with the centromere-specific histone H3 variant CID .
19800102	0	Cap43	34,39	N-myc_downstream_regulated_gene-1	0,33	Cap43	N-myc downstream regulated gene-1	10397	10397	Gene	Gene	play|nsubj|START_ENTITY END_ENTITY|parataxis|play	N-myc_downstream_regulated_gene-1 / Cap43 may play an important role in malignant_progression_of_prostate_cancer , in its close association with E-cadherin .
18272787	0	CapZ	23,27	Nebulin	0,7	CapZ	Nebulin	417771(Tax:9031)	374027(Tax:9031)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc .
11281272	0	CapZ	47,51	actin	15,20	CapZ	actin	417771(Tax:9031)	396526(Tax:9031)	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Interaction of actin with the capping protein , CapZ from sea bass -LRB- Dicentrarchus labrax -RRB- white skeletal muscle .
17190598	0	Capicua	38,45	ATAXIN-1	0,8	Capicua	ATAXIN-1	53560(Tax:7227)	6310	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1_neuropathology .
21402877	0	Caprin-1	0,8	Pou4f3	42,48	Caprin-1	Pou4f3	4076	5459	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic_damage .
26865403	0	Caprin1	45,52	RNG105	37,43	Caprin1	RNG105	53872(Tax:10090)	53872(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Comprehensive behavioral analysis of RNG105 -LRB- Caprin1 -RRB- heterozygous mice : Reduced social interaction and attenuated response to novelty .
21674029	0	Car	104,107	Coxsackievirus_and_Adenovirus_Receptor	64,102	Car	Coxsackievirus and Adenovirus Receptor	13052(Tax:10090)	13052(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Multiple phenotypes in adult mice following inactivation of the Coxsackievirus_and_Adenovirus_Receptor -LRB- Car -RRB- gene .
9147070	0	Car8	59,63	carbonic_anhydrase_VIII	29,52	Car8	carbonic anhydrase VIII	12319(Tax:10090)	12319(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the acatalytic carbonic_anhydrase_VIII gene , Car8 , during mouse embryonic development .
26191606	0	Carbonic_Anhydrase-II	61,82	MicroRNA-21	102,113	Carbonic Anhydrase-II	MicroRNA-21	760	406991	Gene	Gene	START_ENTITY|nmod|Presence Presence|nmod|END_ENTITY	Bile_Acid Conjugated DNA Chimera that Conditionally Inhibits Carbonic_Anhydrase-II in the Presence of MicroRNA-21 .
17724612	0	Carbonic_anhydrase_9	0,20	CA9	22,25	Carbonic anhydrase 9	CA9	768	768	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Carbonic_anhydrase_9 -LRB- CA9 -RRB- expression in tumor cells enhances sensitivity to tirapazamine .
11382925	0	Carbonic_anhydrase_II	0,21	AP-1	28,32	Carbonic anhydrase II	AP-1	760	3727	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Carbonic_anhydrase_II is an AP-1 target gene in osteoclasts .
18444244	0	Carbonic_anhydrase_III	0,22	FAK	97,100	Carbonic anhydrase III	FAK	761	5747	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Carbonic_anhydrase_III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway .
14567991	0	Carbonic_anhydrase_IX	0,21	beta-catenin	94,106	Carbonic anhydrase IX	beta-catenin	611933(Tax:9615)	477032(Tax:9615)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Carbonic_anhydrase_IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin .
15805285	0	Carboxyl-terminal_Src_kinase_homologous_kinase	0,46	CXCR4	91,96	Carboxyl-terminal Src kinase homologous kinase	CXCR4	4145	7852	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Carboxyl-terminal_Src_kinase_homologous_kinase negatively regulates the chemokine receptor CXCR4 through YY1 and impairs CXCR4/CXCL12 -LRB- SDF-1alpha -RRB- - mediated breast_cancer cell migration .
23943800	0	Carboxyl-terminal_modulator_protein	0,35	Akt	57,60	Carboxyl-terminal modulator protein	Akt	117145	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Carboxyl-terminal_modulator_protein positively regulates Akt phosphorylation and acts as an oncogenic driver in breast_cancer .
27075303	0	Carboxylesterase_1	0,18	Hepatocyte_Nuclear_Factor_4a	35,63	Carboxylesterase 1	Hepatocyte Nuclear Factor 4a	1066	3172	Gene	Gene	Regulated|nsubjpass|START_ENTITY Regulated|nmod|END_ENTITY	Carboxylesterase_1 Is Regulated by Hepatocyte_Nuclear_Factor_4a and Protects Against Alcohol - and MCD diet-induced Liver_Injury .
21922598	0	Carboxypeptidase_A6	0,19	CPA6	26,30	Carboxypeptidase A6	CPA6	57094	57094	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Carboxypeptidase_A6 gene -LRB- CPA6 -RRB- mutations in a recessive familial form of febrile_seizures and temporal_lobe_epilepsy and in sporadic temporal_lobe_epilepsy .
17641957	0	Carboxypeptidase_D	0,18	TGF-beta	28,36	Carboxypeptidase D	TGF-beta	1362	7040	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	Carboxypeptidase_D : a novel TGF-beta target gene dysregulated in patients with lupus_erythematosus .
3041137	0	Carboxypeptidase_N	0,18	kininase_I	20,30	Carboxypeptidase N	kininase I	1369	1369	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Carboxypeptidase_N -LRB- kininase_I -RRB- activity in blood and synovial fluid from patients with arthritis .
26176088	0	Carcinoembryonic_Antigen	69,93	Alpha-fetoprotein	103,120	Carcinoembryonic Antigen	Alpha-fetoprotein	1084	174	Gene	Gene	CA72-4|compound|START_ENTITY CA72-4|appos|END_ENTITY	Prognostic Value of Preoperative Serum Levels of Five Tumor Markers -LRB- Carcinoembryonic_Antigen , CA19-9 , Alpha-fetoprotein , CA72-4 , and CA125 -RRB- in Gastric_Cancer .
26976996	0	Carcinoembryonic_Antigen	20,44	CEA	46,49	Carcinoembryonic Antigen	CEA	1084	1084	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	Prognostic Value of Carcinoembryonic_Antigen -LRB- CEA -RRB- , AFP , CA19-9 and CA125 for Patients with Colorectal_Cancer with Peritoneal_Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy .
26974538	0	Carcinoembryonic_Antigen-Related_Cellular_Adhesion_Molecule_6	20,81	CEACAM6	83,90	Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 6	CEACAM6	4680	4680	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Biliary Carcinoembryonic_Antigen-Related_Cellular_Adhesion_Molecule_6 -LRB- CEACAM6 -RRB- as a Biomarker in Cholangiocarcinoma .
1000475	0	Carcinoembryonic_antigen	0,24	CEA	26,29	Carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Carcinoembryonic_antigen -LRB- CEA -RRB- activity in pancreatic juice of patients with pancreatic_carcinoma and pancreatitis .
3545047	0	Carcinoembryonic_antigen	0,24	CEA	26,29	Carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Carcinoembryonic_antigen -LRB- CEA -RRB- expression in early embryogenesis : a study of the first trimester of gestation .
3807878	0	Carcinoembryonic_antigen	1,25	CEA	27,30	Carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Carcinoembryonic_antigen -LRB- CEA -RRB- levels of peripheral and portal blood and tumor histopathology in colorectal_cancer -RSB- .
6365131	0	Carcinoembryonic_antigen	0,24	CEA	26,29	Carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Carcinoembryonic_antigen -LRB- CEA -RRB- expression and heterogeneity in primary and autologous metastatic gastric_tumours demonstrated by a monoclonal antibody .
6604368	0	Carcinoembryonic_antigen	1,25	CEA	27,30	Carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Carcinoembryonic_antigen -LRB- CEA -RRB- levels and their clinical significance in Crohn 's _ disease -RSB- .
15221959	0	Carcinoembryonic_antigen	0,24	IL-10	38,43	Carcinoembryonic antigen	IL-10	1084	3586	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Carcinoembryonic_antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal_carcinoma cells .
9151695	0	Carcinoembryonic_antigen	0,24	Myc	64,67	Carcinoembryonic antigen	Myc	1084	4609	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Carcinoembryonic_antigen , a human tumor marker , cooperates with Myc and Bcl-2 in cellular transformation .
23319418	0	Carcinoembryonic_antigen-related_cell_adhesion_molecule_1	0,57	granulocyte_colony-stimulating_factor	79,116	Carcinoembryonic antigen-related cell adhesion molecule 1	granulocyte colony-stimulating factor	634	1440	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Carcinoembryonic_antigen-related_cell_adhesion_molecule_1 negatively regulates granulocyte_colony-stimulating_factor production by breast_tumor-associated macrophages that mediate tumor angiogenesis .
21368133	0	Carcinoembryonic_antigen-related_cell_adhesion_molecule_16	0,58	alpha-tectorin	74,88	Carcinoembryonic antigen-related cell adhesion molecule 16	alpha-tectorin	388551	7007	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Carcinoembryonic_antigen-related_cell_adhesion_molecule_16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing_loss -LRB- DFNA4 -RRB- .
10900165	0	Cardiotrophin-1	0,15	akt	31,34	Cardiotrophin-1	akt	1489	207	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cardiotrophin-1 phosphorylates akt and BAD , and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes .
12182945	0	Cardiotrophin-1	0,15	endothelin-1	27,39	Cardiotrophin-1	endothelin-1	1489	1906	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Cardiotrophin-1 stimulates endothelin-1 via gp130 in vascular endothelial cells .
12182945	0	Cardiotrophin-1	0,15	gp130	44,49	Cardiotrophin-1	gp130	1489	3572	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|endothelin-1 endothelin-1|nmod|END_ENTITY	Cardiotrophin-1 stimulates endothelin-1 via gp130 in vascular endothelial cells .
18055523	0	Cardiotrophin-1	0,15	intercellular_adhesion_molecule-1	27,60	Cardiotrophin-1	intercellular adhesion molecule-1	1489	3383	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Cardiotrophin-1 stimulates intercellular_adhesion_molecule-1 and monocyte_chemoattractant_protein-1 in human aortic endothelial cells .
19187601	0	Cardiotrophin-1	0,15	intercellular_adhesion_molecule-1	24,57	Cardiotrophin-1	intercellular adhesion molecule-1	1489	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Cardiotrophin-1 induces intercellular_adhesion_molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells .
17197193	0	Cardiotrophin-1	0,15	interleukin-6	24,37	Cardiotrophin-1	interleukin-6	1489	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells .
17637508	0	Cardiotrophin-1	0,15	interleukin-6	24,37	Cardiotrophin-1	interleukin-6	1489	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Cardiotrophin-1 induces interleukin-6 synthesis in human monocytes .
23935888	0	Cardiotrophin-1	0,15	matrix_metalloproteinase-1	24,50	Cardiotrophin-1	matrix metalloproteinase-1	1489	4312	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Cardiotrophin-1 induces matrix_metalloproteinase-1 in human aortic endothelial cells .
16427785	0	Cardiotrophin-1	0,15	monocyte_chemoattractant_protein-1	24,58	Cardiotrophin-1	monocyte chemoattractant protein-1	1489	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Cardiotrophin-1 induces monocyte_chemoattractant_protein-1 synthesis in human umbilical vein endothelial cells .
8952522	0	Cardiotrophin-1	0,15	tumor_necrosis_factor	25,46	Cardiotrophin-1	tumor necrosis factor	13019(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Cardiotrophin-1 inhibits tumor_necrosis_factor production in the heart and serum of lipopolysaccharide-treated mice and in vitro in mouse blood cells .
9038192	0	Cardiotrophin_1	0,15	CT-1	17,21	Cardiotrophin 1	CT-1	1489	1489	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Cardiotrophin_1 -LRB- CT-1 -RRB- inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway .
22863532	0	Carm1	0,5	Pax7	16,20	Carm1	Pax7	10498	5081	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions .
11356195	0	Carma1	0,6	Bcl10	45,50	Carma1	Bcl10	84433	8915	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Carma1 , a CARD-containing binding partner of Bcl10 , induces Bcl10 phosphorylation and NF-kappaB activation .
11356195	0	Carma1	0,6	Bcl10	60,65	Carma1	Bcl10	84433	8915	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Carma1 , a CARD-containing binding partner of Bcl10 , induces Bcl10 phosphorylation and NF-kappaB activation .
18192506	0	Carma1	75,81	NF-kappaB	86,95	Carma1	NF-kappaB	108723(Tax:10090)	18033(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production .
15044358	0	Carnitine_palmitoyltransferase-1	0,32	CPT-1	34,39	Carnitine palmitoyltransferase-1	CPT-1	12895(Tax:10090)	12895(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Carnitine_palmitoyltransferase-1 -LRB- CPT-1 -RRB- activity stimulation by cerulenin via sympathetic nervous system activation overrides cerulenin 's peripheral effect .
9566999	0	Carnitine_palmitoyltransferase_I	0,32	CPT_I	34,39	Carnitine palmitoyltransferase I	CPT I	399528(Tax:9823)	399528(Tax:9823)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Carnitine_palmitoyltransferase_I -LRB- CPT_I -RRB- activity and its regulation by malonyl-CoA are modulated by age and cold exposure in skeletal muscle mitochondria from newborn pigs .
10661386	0	Cartilage_oligomeric_matrix_protein	0,35	COMP	37,41	Cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- levels in digital sheath synovial fluid and serum with tendon_injury .
17307734	0	Cartilage_oligomeric_matrix_protein	0,35	granulin-epithelin_precursor	52,80	Cartilage oligomeric matrix protein	granulin-epithelin precursor	1311	2896	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Cartilage_oligomeric_matrix_protein associates with granulin-epithelin_precursor -LRB- GEP -RRB- and potentiates GEP-stimulated chondrocyte proliferation .
26045608	0	Cartilage_oligomeric_matrix_protein	0,35	thrombin	62,70	Cartilage oligomeric matrix protein	thrombin	12845(Tax:10090)	14061(Tax:10090)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Cartilage_oligomeric_matrix_protein is a natural inhibitor of thrombin .
18256281	0	Cas	8,11	HEPL	27,31	Cas	HEPL	12927(Tax:10090)	57091	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	A novel Cas family member , HEPL , regulates FAK and cell spreading .
17488714	0	Cas	13,16	SRC	0,3	Cas	SRC	9564	6714	Gene	Gene	utilizes|dobj|START_ENTITY utilizes|nsubj|END_ENTITY	SRC utilizes Cas to block gap junctional communication mediated by connexin43 .
9748234	0	Cas	23,26	p130	18,22	Cas	p130	9564	9221	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Direct binding of p130 -LRB- Cas -RRB- to the guanine_nucleotide exchange factor C3G .
8639268	0	Cas-1	168,173	catalase	153,161	Cas-1	catalase	12359(Tax:10090)	12359(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Distinct mRNA-binding proteins interacting with short repeat sequences of the 3 ' UTR may be involved in the post-transcriptional regulation of the mouse catalase gene , Cas-1 .
18465784	0	Cas-L	85,90	Crk-associated_substrate_lymphocyte_type	43,83	Cas-L	Crk-associated substrate lymphocyte type	4739	4739	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Expression and tyrosine phosphorylation of Crk-associated_substrate_lymphocyte_type -LRB- Cas-L -RRB- protein in human neutrophils .
11112339	0	Cas-interacting_zinc_finger_protein	18,53	CIZ	55,58	Cas-interacting zinc finger protein	CIZ	269800(Tax:10090)	269800(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Cas-interacting_zinc_finger_protein -LRB- CIZ -RRB- suppresses proliferation and enhances expression of type I collagen gene in osteoblast-like MC3T3E1 cells .
8002359	0	Casa	87,91	Casa	95,99	Casa	Casa	1446	1446	Gene	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	Critical pedagogy and its application to health education : a critical appraisal of the Casa en Casa model .
8002359	0	Casa	95,99	Casa	87,91	Casa	Casa	1446	1446	Gene	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	Critical pedagogy and its application to health education : a critical appraisal of the Casa en Casa model .
17101137	0	Casein_kinase_1_delta	0,21	SNARE_associated_protein_snapin	52,83	Casein kinase 1 delta	SNARE associated protein snapin	1453	23557	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Casein_kinase_1_delta -LRB- CK1delta -RRB- interacts with the SNARE_associated_protein_snapin .
20637175	0	Casein_kinase_1delta	0,20	deoxycytidine_kinase	49,69	Casein kinase 1delta	deoxycytidine kinase	1453	1633	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Casein_kinase_1delta activates human recombinant deoxycytidine_kinase by Ser-74 phosphorylation , but is not involved in the in vivo regulation of its activity .
10547286	0	Casein_kinase_2	0,15	nucleosome_assembly_protein-1	45,74	Casein kinase 2	nucleosome assembly protein-1	48448(Tax:7227)	37798(Tax:7227)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Casein_kinase_2 binds and phosphorylates the nucleosome_assembly_protein-1 -LRB- NAP1 -RRB- in Drosophila_melanogaster .
17942896	0	Casein_kinase_2-interacting_protein-1	0,37	Akt	47,50	Casein kinase 2-interacting protein-1	Akt	51177	207	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Casein_kinase_2-interacting_protein-1 , a novel Akt pleckstrin homology domain-interacting protein , down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo .
8622692	0	Casein_kinase_II	0,16	I_kappa_B_alpha	32,47	Casein kinase II	I kappa B alpha	1457	4792	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Casein_kinase_II phosphorylates I_kappa_B_alpha at S-283 , S-289 , S-293 , and T-291 and is required for its degradation .
12446764	0	Casein_kinase_II	0,16	fragile_X_mental_retardation_protein	36,72	Casein kinase II	fragile X mental retardation protein	48448(Tax:7227)	37528(Tax:7227)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Casein_kinase_II phosphorylates the fragile_X_mental_retardation_protein and modulates its biological properties .
2200737	0	Casein_kinase_II	0,16	serum_response_factor	54,75	Casein kinase II	serum response factor	1457	6722	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Casein_kinase_II enhances the DNA binding activity of serum_response_factor .
8268212	0	Casein_kinase_II_beta-subunit	0,29	catalytic_alpha-subunit	59,82	Casein kinase II beta-subunit	catalytic alpha-subunit	32132(Tax:7227)	34792(Tax:7227)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Casein_kinase_II_beta-subunit inhibits the activity of the catalytic_alpha-subunit in the absence of salt .
12556519	0	Casein_kinase_I_epsilon	0,23	Frat-1	57,63	Casein kinase I epsilon	Frat-1	102800317	10023	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Casein_kinase_I_epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin .
12183362	0	Casein_kinase_Iepsilon	45,67	Diversin	27,35	Casein kinase Iepsilon	Diversin	43673(Tax:7227)	378477(Tax:7955)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The ankyrin repeat protein Diversin recruits Casein_kinase_Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling .
12183362	0	Casein_kinase_Iepsilon	45,67	beta-catenin	75,87	Casein kinase Iepsilon	beta-catenin	43673(Tax:7227)	31151(Tax:7227)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nmod|complex complex|amod|END_ENTITY	The ankyrin repeat protein Diversin recruits Casein_kinase_Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling .
21596750	0	Casitas_B_lineage_lymphoma	4,30	platelet-derived_growth_factor_receptor_alpha	155,200	Casitas B lineage lymphoma	platelet-derived growth factor receptor alpha	867	5156	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	The Casitas_B_lineage_lymphoma -LRB- Cbl -RRB- mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived_growth_factor_receptor_alpha and fibroblast_growth_factor_receptor_2 ubiquitination .
16103071	0	Caspase-1	0,9	ETS1	37,41	Caspase-1	ETS1	12362(Tax:10090)	23871(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis .
25501827	0	Caspase-1	0,9	GATA4	43,48	Caspase-1	GATA4	834	2626	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate .
20920345	0	Caspase-1	0,9	IL-1b	100,105	Caspase-1	IL-1b	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|advcl|contributing contributing|nmod|maturation maturation|compound|END_ENTITY	Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1b maturation .
21731762	0	Caspase-1	0,9	IL-1b	20,25	Caspase-1	IL-1b	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY secretion|amod|dependent secretion|compound|END_ENTITY	Caspase-1 dependent IL-1b secretion is critical for host defense in a mouse model of Chlamydia_pneumoniae lung infection .
26344742	0	Caspase-1	0,9	IL-1b	20,25	Caspase-1	IL-1b	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
26344742	0	Caspase-1	0,9	IL-1b	20,25	Caspase-1	IL-1b	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
27096899	0	Caspase-1	133,142	IL-1b	52,57	Caspase-1	IL-1b	834	3553	Gene	Gene	Requirements|nmod|START_ENTITY Induction|nmod|Requirements Induction|nmod|END_ENTITY	Lipopolysaccharide-Mediated Induction of Concurrent IL-1b and IL-23 Expression in THP-1 Cells Exhibits Differential Requirements for Caspase-1 and Cathepsin_B Activity .
20596246	0	Caspase-1	68,77	Interleukin-1b	92,106	Caspase-1	Interleukin-1b	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1b in Intracerebral_Hemorrhage Mouse Model .
25744023	0	Caspase-1	42,51	NLRP1	9,14	Caspase-1	NLRP1	834	22861	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal_degeneration-associated Caspase-6 activation .
25552542	0	Caspase-1	93,102	NLRP3	121,126	Caspase-1	NLRP3	834	114548	Gene	Gene	START_ENTITY|nmod|Absence Absence|nmod|END_ENTITY	Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling .
26989816	0	Caspase-1	14,23	NLRP3	75,80	Caspase-1	NLRP3	12362(Tax:10090)	216799(Tax:10090)	Gene	Gene	START_ENTITY|dobj|Independently Independently|nmod|END_ENTITY	TNF-a Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells .
16123779	0	Caspase-1	0,9	caspase-6	24,33	Caspase-1	caspase-6	834	839	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Caspase-1 activation of caspase-6 in human apoptotic neurons .
23703390	0	Caspase-1	0,9	p63	31,34	Caspase-1	p63	834	8626	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Caspase-1 is a novel target of p63 in tumor suppression .
18426910	0	Caspase-2	0,9	BID	22,25	Caspase-2	BID	835	637	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress .
25378403	0	Caspase-2	83,92	Phosphatase_2A	125,139	Caspase-2	Phosphatase 2A	835	5524	Gene	Gene	Suppression|compound|START_ENTITY Suppression|nmod|END_ENTITY	Metabolic Control of Ca2 + / Calmodulin-dependent Protein Kinase II -LRB- CaMKII -RRB- - mediated Caspase-2 Suppression by the B55b/Protein Phosphatase_2A -LRB- PP2A -RRB- .
22486813	0	Caspase-2	84,93	Sorting_nexin_5	0,15	Caspase-2	Sorting nexin 5	12366(Tax:10090)	69178(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Sorting_nexin_5 of a new diagnostic marker of papillary_thyroid_carcinoma regulates Caspase-2 .
23540413	0	Caspase-2	0,9	caspase-3	32,41	Caspase-2	caspase-3	835	836	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells .
17553417	0	Caspase-3	0,9	BACE	38,42	Caspase-3	BACE	836	23621	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Caspase-3 cleavage of GGA3 stabilizes BACE : implications for Alzheimer 's _ disease .
11683923	0	Caspase-3	0,9	Bcl-2	37,42	Caspase-3	Bcl-2	836	596	Gene	Gene	activity|amod|START_ENTITY activity|nmod|family family|compound|END_ENTITY	Caspase-3 activity and expression of Bcl-2 family in human neutrophils by Helicobacter_pylori water-soluble proteins .
12578676	0	Caspase-3	39,48	Bcl-2	12,17	Caspase-3	Bcl-2	836	596	Gene	Gene	Protein|nmod|START_ENTITY Protein|compound|END_ENTITY	Cleavage of Bcl-2 Protein by Activated Caspase-3 Is Associated with Inactivation of Lyn -LRB- p53/56 -RRB- Kinase Activity in Human M-07e Leukemic Cells during Apoptosis .
9818030	0	Caspase-3	0,9	Bcl-2	64,69	Caspase-3	Bcl-2	836	596	Gene	Gene	activation|amod|START_ENTITY responsible|nsubj|activation responsible|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Caspase-3 activation is not responsible for vinblastine-induced Bcl-2 phosphorylation and G2/M arrest in human small_cell_lung_carcinoma Ms-1 cells .
26401931	0	Caspase-3	15,24	CXCL1	0,5	Caspase-3	CXCL1	12367(Tax:10090)	14825(Tax:10090)	Gene	Gene	Cleavage|compound|START_ENTITY Cleavage|compound|END_ENTITY	CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice : Implications in Alzheimer 's _ Disease .
16427076	0	Caspase-3	0,9	MEKK1	31,36	Caspase-3	MEKK1	836	4214	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity .
11306462	0	Caspase-3	0,9	P39	126,129	Caspase-3	P39	836	9114	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Caspase-3 activation by lysosomal enzymes in cytochrome_c-independent apoptosis in myelodysplastic_syndrome-derived cell line P39 .
16309216	0	Caspase-3	0,9	PARP	38,42	Caspase-3	PARP	836	142	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Caspase-3 activation and induction of PARP cleavage by cyclic_dipeptide cyclo -LRB- Phe-Pro -RRB- in HT-29 cells .
20856198	0	Caspase-3	0,9	XIAP	18,22	Caspase-3	XIAP	836	331	Gene	Gene	cleaves|amod|START_ENTITY END_ENTITY|nsubj|cleaves	Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis .
21996423	0	Caspase-3	0,9	c-Jun	30,35	Caspase-3	c-Jun	836	3725	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Caspase-3 is a target gene of c-Jun : ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons .
16121124	0	Caspase-3	0,9	caspase-activated_DNase	47,70	Caspase-3	caspase-activated DNase	836	1677	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Caspase-3 cleavage and nuclear localization of caspase-activated_DNase in human temporal_lobe_epilepsy .
23519117	0	Caspase-3	0,9	hnRNP_K	18,25	Caspase-3	hnRNP K	836	3190	Gene	Gene	cleaves|amod|START_ENTITY END_ENTITY|nsubj|cleaves	Caspase-3 cleaves hnRNP_K in erythroid differentiation .
26574931	0	Caspase-3	16,25	miR-155	0,7	Caspase-3	miR-155	12367(Tax:10090)	387173(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-155 targets Caspase-3 mRNA in activated macrophages .
11291926	0	Caspase-3	0,9	p53	135,138	Caspase-3	p53	836	7157	Gene	Gene	activation|amod|START_ENTITY downstream|nsubj|activation downstream|xcomp|carrying carrying|dobj|gene gene|compound|END_ENTITY	Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic_carcinoma cells carrying a mutant p53 gene .
16427076	0	Caspase-3	0,9	p53	46,49	Caspase-3	p53	836	7157	Gene	Gene	cleavage|amod|START_ENTITY promotes|nsubj|cleavage promotes|dobj|activity activity|nummod|END_ENTITY	Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity .
17130234	0	Caspase-3	0,9	protein_tyrosine_phosphatase_PEST	72,105	Caspase-3	protein tyrosine phosphatase PEST	836	5782	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Caspase-3 regulates catalytic activity and scaffolding functions of the protein_tyrosine_phosphatase_PEST , a novel modulator of the apoptotic response .
19133298	0	Caspase-6	19,28	Caspase-6	51,60	Caspase-6	Caspase-6	839	839	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Self-activation of Caspase-6 in vitro and in vivo : Caspase-6 activation does not induce cell death in HEK293T cells .
19133298	0	Caspase-6	51,60	Caspase-6	19,28	Caspase-6	Caspase-6	839	839	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Self-activation of Caspase-6 in vitro and in vivo : Caspase-6 activation does not induce cell death in HEK293T cells .
22649225	0	Caspase-6	0,9	huntingtin	76,86	Caspase-6	huntingtin	12368(Tax:10090)	15194(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY modulates|nsubj|activity modulates|dobj|levels levels|nmod|protein protein|compound|END_ENTITY	Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino_acid proteolytic fragment .
20159985	0	Caspase-7	0,9	ORF57	60,65	Caspase-7	ORF57	840	4961525(Tax:37296)	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Caspase-7 cleavage of Kaposi_sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression .
25451151	0	Caspase-8	16,25	IL-1b	29,34	Caspase-8	IL-1b	12370(Tax:10090)	16176(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Novel Roles for Caspase-8 in IL-1b and Inflammasome Regulation .
26100631	0	Caspase-8	0,9	NLRP3	42,47	Caspase-8	NLRP3	12370(Tax:10090)	216799(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling .
16920630	0	Caspase-8	0,9	TRAF6	48,53	Caspase-8	TRAF6	841	7189	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Caspase-8 regulation by direct interaction with TRAF6 in T_cell_receptor-induced NF-kappaB activation .
11992615	0	Caspase-8	0,9	TRAIL	114,119	Caspase-8	TRAIL	841	8743	Gene	Gene	activation|amod|START_ENTITY sufficient|nsubj|activation sufficient|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Caspase-8 activation is necessary but not sufficient for tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis in the prostatic_carcinoma cell line LNCaP .
26426685	0	Caspase-8	0,9	TRAIL	24,29	Caspase-8	TRAIL	841	8743	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast_cancer cell lines .
23418437	0	Caspase-8	0,9	bid	106,109	Caspase-8	bid	841	637	Gene	Gene	vesicles|nummod|START_ENTITY provides|nsubj|vesicles provides|dobj|platform platform|nmod|END_ENTITY	Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid .
10388534	0	Caspase-8	0,9	caspase-3	19,28	Caspase-8	caspase-3	841	836	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Caspase-8 mediates caspase-3 activation and cytochrome_c release during singlet oxygen-induced apoptosis of HL-60 cells .
26700476	0	Caspase-9	29,38	AKT1	62,66	Caspase-9	AKT1	842	207	Gene	Gene	START_ENTITY|nmod|Stimulation Stimulation|nmod|END_ENTITY	Cinnamomum cassia Suppresses Caspase-9 through Stimulation of AKT1 in MCF-7 Cells but Not in MDA-MB-231 Cells .
11393657	0	Caspase-9	49,58	CASP9	60,65	Caspase-9	CASP9	842	842	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Two novel single-nucleotide polymorphisms of the Caspase-9 -LRB- CASP9 -RRB- gene in the Japanese population .
11550085	0	Caspase-9	0,9	caspase-3	24,33	Caspase-9	caspase-3	12371(Tax:10090)	12367(Tax:10090)	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo .
11739563	0	Caspase-9	0,9	caspase-8	43,52	Caspase-9	caspase-8	12371(Tax:10090)	12370(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|nmod|activation activation|amod|END_ENTITY	Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine-induced Parkinson 's _ disease .
11425895	0	Caspase-activated_DNase	0,23	DNA_fragmentation_factor_40	24,51	Caspase-activated DNase	DNA fragmentation factor 40	84359(Tax:10116)	84359(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Caspase-activated_DNase / DNA_fragmentation_factor_40 mediates apoptotic DNA fragmentation in transient_cerebral_ischemia and in neuronal_cultures .
26869103	0	Caspase3	115,123	Hax1	136,140	Caspase3	Hax1	836	10456	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1 .
12011445	0	Caspase_2	20,29	Cyclin_D3	0,9	Caspase 2	Cyclin D3	835	896	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Cyclin_D3 activates Caspase_2 , connecting cell proliferation with cell death .
24495616	0	Caspase_3	6,15	Bcl-2	0,5	Caspase 3	Bcl-2	836	403416(Tax:9615)	Gene	Gene	imbalance|amod|START_ENTITY favors|nsubj|imbalance END_ENTITY|parataxis|favors	Bcl-2 / Caspase_3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory_bowel_disease .
26372956	0	Caspase_3	0,9	Pax7	22,26	Caspase 3	Pax7	836	5081	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Caspase_3 cleavage of Pax7 inhibits self-renewal of satellite cells .
10611247	0	Caspase_3	0,9	SLK	47,50	Caspase 3	SLK	836	9748	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Caspase_3 cleavage of the Ste20-related_kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region .
21691071	0	Caspase_3	0,9	caspase_8	31,40	Caspase 3	caspase 8	836	841	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Caspase_3 is activated through caspase_8 instead of caspase_9 during H2O2-induced apoptosis in HeLa cells .
20035719	0	Caspase_3	0,9	interleukin-33	54,68	Caspase 3	interleukin-33	12367(Tax:10090)	77125(Tax:10090)	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	Caspase_3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation .
21700414	0	Caspase_3_and_5	33,48	death_receptor_4	15,31	Caspase 3 and 5	death receptor 4	836;838	8797	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Association of death_receptor_4 , Caspase_3_and_5 gene polymorphism with increased risk to bladder_cancer in North Indians .
14679087	0	Caspase_7	0,9	IDDM_17	45,52	Caspase 7	IDDM 17	840	8691	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Caspase_7 is a positional candidate gene for IDDM_17 in a Bedouin Arab family .
10894163	0	Casper	16,22	c-FLIP	24,30	Casper	c-FLIP	12633(Tax:10090)	12633(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|appos|END_ENTITY	Requirement for Casper -LRB- c-FLIP -RRB- in regulation of death receptor-induced apoptosis and embryonic development .
14592966	0	Caspr	39,44	Nogo-A	0,6	Caspr	Nogo-A	84008(Tax:10116)	83765(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Nogo-A at CNS paranodes is a ligand of Caspr : possible regulation of K -LRB- + -RRB- channel localization .
9396755	0	Caspr	28,33	neurexin_IV	50,61	Caspr	neurexin IV	8506	8506	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The axonal membrane protein Caspr , a homologue of neurexin_IV , is a component of the septate-like paranodal junctions that assemble during myelination .
26647347	0	Caspr2	23,29	Cntnap2	14,21	Caspr2	Cntnap2	66797(Tax:10090)	66797(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Cntnap2 -LRB- Caspr2 -RRB- in multiple levels of sensory systems .
25279559	0	Caspr4	0,6	LNX2	24,28	Caspr4	LNX2	170571(Tax:10090)	140887(Tax:10090)	Gene	Gene	Interaction|compound|START_ENTITY Interaction|nmod|END_ENTITY	Caspr4 Interaction with LNX2 Modulates the Proliferation and Neuronal Differentiation of Mouse Neural Progenitor Cells .
12163476	0	Cast	0,4	RIM1	105,109	Cast	RIM1	292657(Tax:10116)	84556(Tax:10116)	Gene	Gene	START_ENTITY|dep|protein protein|acl:relcl|forms forms|nmod|END_ENTITY	Cast : a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1 .
26913565	0	Casz1	33,38	Prrxl1	99,105	Casz1	Prrxl1	69743(Tax:10090)	107751(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late born excitatory interneurons .
3526334	0	Cat2	29,33	catalase	19,27	Cat2	catalase	542230(Tax:4577)	542230(Tax:4577)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Spatial pattern of catalase -LRB- Cat2 -RRB- gene activation in scutella during postgerminative development in maize .
11169757	0	Cat8	0,4	MDH2	98,102	Cat8	MDH2	855323(Tax:4932)	853994(Tax:4932)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|END_ENTITY	Cat8 and Sip4 mediate regulated transcriptional activation of the yeast malate dehydrogenase gene MDH2 by three carbon source-responsive promoter elements .
15182856	0	Catalase	0,8	Grb2	15,19	Catalase	Grb2	847	2885	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Catalase binds Grb2 in tumor cells when stimulated with serum or ligands for integrin receptors .
15498507	0	Catalase	0,8	inducible_nitric_oxide_synthase	35,66	Catalase	inducible nitric oxide synthase	12359(Tax:10090)	18126(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Catalase induces the expression of inducible_nitric_oxide_synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells .
11556837	0	Catechol-O-Methyltransferase	0,28	COMT	30,34	Catechol-O-Methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Catechol-O-Methyltransferase -LRB- COMT -RRB- gene polymorphism and breast_cancer risk in young women .
25600541	0	Catechol-O-Methyltransferase_Gene_Val158Met	25,68	COMT	70,74	Catechol-O-Methyltransferase Gene Val158Met	COMT	1312	1312	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	The Relationship Between Catechol-O-Methyltransferase_Gene_Val158Met -LRB- COMT -RRB- Polymorphism and Premorbid Cannabis Use in Turkish Male Patients with Schizophrenia .
11693181	0	Catechol-O-methyltransferase	0,28	COMT	30,34	Catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- genetic polymorphism in a Turkish population .
17510945	0	Catechol-O-methyltransferase	0,28	COMT	43,47	Catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Catechol-O-methyltransferase polymorphism -LRB- COMT -RRB- in suicide attempters : a possible gender effect on anger traits .
18270997	0	Catechol-O-methyltransferase	0,28	COMT	30,34	Catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- gene variants : possible association of the Val158Met variant with opiate_addiction in Hispanic women .
20219633	0	Catechol-O-methyltransferase	0,28	COMT	30,34	Catechol-O-methyltransferase	COMT	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- inhibition reduces spinal nociceptive activity .
21934178	0	Catechol-O-methyltransferase	0,28	COMT	30,34	Catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- gene variants and pain in chronic pancreatitis .
23446089	0	Catechol-O-methyltransferase	0,28	COMT	30,34	Catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- gene polymorphisms as risk factor in temporomandibular_disorders patients from Southern Italy .
23613844	0	Catechol-O-methyltransferase	0,28	COMT	30,34	Catechol-O-methyltransferase	COMT	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Catechol-O-methyltransferase -LRB- COMT -RRB- protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain .
25080080	0	Catechol_O-Methyltransferase	23,51	COMT	53,57	Catechol O-Methyltransferase	COMT	1312	1312	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Medicinal Chemistry of Catechol_O-Methyltransferase -LRB- COMT -RRB- Inhibitors and Their Therapeutic Utility .
12799619	0	Catechol_O-methyltransferase	0,28	COMT	30,34	Catechol O-methyltransferase	COMT	1312	1312	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Catechol_O-methyltransferase -LRB- COMT -RRB- mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia .
24039968	0	Catechol_O-methyltransferase	24,52	COMT	54,58	Catechol O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between the Catechol_O-methyltransferase -LRB- COMT -RRB- Val158met polymorphism and different dimensions of impulsivity .
23222817	0	Cathepsin_B	0,11	Sox2	92,96	Cathepsin B	Sox2	1508	6657	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Cathepsin_B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression .
16781460	0	Cathepsin_B	0,11	THP-1	72,77	Cathepsin B	THP-1	1508	2736	Gene	Gene	target|nsubj|START_ENTITY target|nmod|nitroxyl nitroxyl|nmod|monocyte/macrophages monocyte/macrophages|compound|END_ENTITY	Cathepsin_B is a differentiation-resistant target for nitroxyl -LRB- HNO -RRB- in THP-1 monocyte/macrophages .
23986436	0	Cathepsin_B	0,11	autophagy-related_7	27,46	Cathepsin B	autophagy-related 7	64529(Tax:10116)	312647(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Cathepsin_B contributes to autophagy-related_7 -LRB- Atg7 -RRB- - induced nod-like_receptor_3 -LRB- NLRP3 -RRB- - dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line .
10690542	0	Cathepsin_B	0,11	cathepsin_D	102,113	Cathepsin B	cathepsin D	1508	1509	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Cathepsin_B , a prognostic indicator in lymph node-negative breast_carcinoma patients : comparison with cathepsin_D , cathepsin_L , and other clinical indicators .
7988031	0	Cathepsin_B	0,11	interleukin-1	95,108	Cathepsin B	interleukin-1	1508	3552	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Cathepsin_B and N-acetyl-beta-D-glucosaminidase in human synovial cells in culture : effects of interleukin-1 .
10210109	0	Cathepsin_B	0,11	p53	13,16	Cathepsin B	p53	1508	7157	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Cathepsin_B , p53 expression and AgNORs_in_transitional_cell_carcinoma .
16534247	0	Cathepsin_B	0,11	trypsinogen_1	28,41	Cathepsin B	trypsinogen 1	1508	5644	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cathepsin_B activates human trypsinogen_1 but not proelastase 2 or procarboxypeptidase_B .
1900515	0	Cathepsin_B	0,11	urokinase-type_plasminogen_activator	102,138	Cathepsin B	urokinase-type plasminogen activator	1508	5328	Gene	Gene	efficiently|compound|START_ENTITY activates|nsubj|efficiently activates|dobj|form form|nmod|END_ENTITY	Cathepsin_B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type_plasminogen_activator -LRB- Pro-uPA -RRB- .
22388353	0	Cathepsin_D	46,57	Aven	27,31	Cathepsin D	Aven	1509	57099	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	The Apaf-1-binding protein Aven is cleaved by Cathepsin_D to unleash its anti-apoptotic potential .
26682926	0	Cathepsin_D	0,11	cathepsin_B	56,67	Cathepsin D	cathepsin B	13033(Tax:10090)	13030(Tax:10090)	Gene	Gene	implicated|nsubjpass|START_ENTITY implicated|nmod|END_ENTITY	Cathepsin_D in pancreatic acinar cells is implicated in cathepsin_B and L degradation , but not in autophagic activity .
16263712	0	Cathepsin_D	0,11	thioredoxin-1	46,59	Cathepsin D	thioredoxin-1	1509	7295	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	Cathepsin_D and H2O2 stimulate degradation of thioredoxin-1 : implication for endothelial cell apoptosis .
22546226	0	Cathepsin_E	0,11	endothelin-1	68,80	Cathepsin E	endothelin-1	13034(Tax:10090)	13614(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|production production|nmod|END_ENTITY	Cathepsin_E induces itch-related response through the production of endothelin-1 in mice .
24532668	0	Cathepsin_G	0,11	PLTP	58,62	Cathepsin G	PLTP	13035(Tax:10090)	18830(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	Cathepsin_G degradation of phospholipid_transfer_protein -LRB- PLTP -RRB- augments pulmonary_inflammation .
15100291	0	Cathepsin_G	0,11	myelin_basic_protein	86,106	Cathepsin G	myelin basic protein	1511	4155	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|processing processing|nmod|END_ENTITY	Cathepsin_G , and not the asparagine-specific endoprotease , controls the processing of myelin_basic_protein in lysosomes from human B lymphocytes .
24532668	0	Cathepsin_G	0,11	phospholipid_transfer_protein	27,56	Cathepsin G	phospholipid transfer protein	13035(Tax:10090)	18830(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Cathepsin_G degradation of phospholipid_transfer_protein -LRB- PLTP -RRB- augments pulmonary_inflammation .
26219353	0	Cathepsin_K	55,66	Matrix-metalloproteinase-9	0,26	Cathepsin K	Matrix-metalloproteinase-9	1513	4318	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin_K .
26219353	0	Cathepsin_K	55,66	Matrix-metalloproteinase-9	0,26	Cathepsin K	Matrix-metalloproteinase-9	1513	4318	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin_K .
16183211	0	Cathepsin_L	0,11	cathepsin_B	51,62	Cathepsin L	cathepsin B	1514	1508	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Cathepsin_L in glioma progression : comparison with cathepsin_B .
24964046	0	Cathepsin_S	0,11	PAR2	24,28	Cathepsin S	PAR2	1520	2150	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Cathepsin_S signals via PAR2 and generates a novel tethered ligand receptor agonist .
25118282	0	Cathepsin_S	0,11	PAR2	59,63	Cathepsin S	PAR2	13040(Tax:10090)	14063(Tax:10090)	Gene	Gene	causes|nsubj|START_ENTITY causes|dobj|pain pain|nmod|agonism agonism|nmod|END_ENTITY	Cathepsin_S causes inflammatory pain via biased agonism of PAR2 and TRPV4 .
26567242	0	Cathepsin_S	0,11	Protease-Activated_Receptor-2	24,53	Cathepsin S	Protease-Activated Receptor-2	13040(Tax:10090)	14063(Tax:10090)	Gene	Gene	Cleavage|compound|START_ENTITY Cleavage|nmod|END_ENTITY	Cathepsin_S Cleavage of Protease-Activated_Receptor-2 on Endothelial Cells Promotes Microvascular_Diabetes_Complications .
11306582	0	Cathepsin_S	0,11	cathepsin_L	40,51	Cathepsin S	cathepsin L	13040(Tax:10090)	13039(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Cathepsin_S regulates the expression of cathepsin_L and the turnover of gamma-interferon-inducible_lysosomal_thiol_reductase in B lymphocytes .
25101494	0	Catsper1	49,57	Sox5	26,30	Catsper1	Sox5	225865(Tax:10090)	20678(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression .
10476966	0	Caudal	0,6	Hox	14,17	Caudal	Hox	35341(Tax:7227)	42536(Tax:7227)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Caudal is the Hox gene that specifies the most posterior Drosophile segment .
22396494	0	Cav1	102,106	Shh	110,113	Cav1	Shh	12389(Tax:10090)	20423(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Genetic ablation of Cav1 differentially affects melanoma_tumor growth and metastasis in mice : role of Cav1 in Shh heterotypic signaling and transendothelial migration .
18065769	0	Caveolin-1	0,10	ALK1	93,97	Caveolin-1	ALK1	857	94	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae .
16979166	0	Caveolin-1	0,10	BRCA1	20,25	Caveolin-1	BRCA1	857	672	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast_cancer cells .
25594072	0	Caveolin-1	27,37	BRCA1	57,62	Caveolin-1	BRCA1	857	672	Gene	Gene	Down-Regulation|compound|START_ENTITY Down-Regulation|nmod|Dysfunction Dysfunction|compound|END_ENTITY	A Novel Pathway that Links Caveolin-1 Down-Regulation to BRCA1 Dysfunction in Serous Epithelial Ovarian_Cancer Cells .
16714282	0	Caveolin-1	0,10	Cdc42	32,37	Caveolin-1	Cdc42	857	998	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Caveolin-1 functions as a novel Cdc42 guanine_nucleotide dissociation inhibitor in pancreatic beta-cells .
24089527	0	Caveolin-1	0,10	Derlin-1	26,34	Caveolin-1	Derlin-1	857	79139	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex .
26690923	0	Caveolin-1	0,10	EAAT1	61,66	Caveolin-1	EAAT1	399006(Tax:8355)	398856(Tax:8355)	Gene	Gene	Sensitivity|compound|START_ENTITY Sensitivity|nmod|END_ENTITY	Caveolin-1 Sensitivity of Excitatory Amino_Acid Transporters EAAT1 , EAAT2 , EAAT3 , and EAAT4 .
19483462	0	Caveolin-1	0,10	EGFR	21,25	Caveolin-1	EGFR	857	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	Caveolin-1 regulates EGFR signaling in MCF-7_breast_cancer cells and enhances gefitinib-induced tumor cell inhibition .
21721581	0	Caveolin-1	0,10	HO-1	59,63	Caveolin-1	HO-1	857	3162	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Caveolin-1 is a competitive inhibitor of heme_oxygenase-1 -LRB- HO-1 -RRB- with heme : identification of a minimum sequence in caveolin-1 for binding to HO-1 .
12716887	0	Caveolin-1	0,10	N-acetylglucosaminyltransferase_III	52,87	Caveolin-1	N-acetylglucosaminyltransferase III	857	4248	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase_III within the golgi apparatus .
24643062	0	Caveolin-1	0,10	NS3	54,57	Caveolin-1	NS3	857	3845	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin-1 in lipid rafts interacts with dengue virus NS3 during polyprotein processing and replication in HMEC-1 cells .
19013132	0	Caveolin-1	0,10	Rab5	21,25	Caveolin-1	Rab5	857	5868	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction .
24625804	0	Caveolin-1	0,10	Rac1	77,81	Caveolin-1	Rac1	857	5879	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|invasion invasion|nmod|regulation regulation|nmod|activation activation|compound|END_ENTITY	Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization .
21918362	0	Caveolin-1	0,10	SHP-2	58,63	Caveolin-1	SHP-2	857	5781	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|activation activation|compound|END_ENTITY	Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes .
22406084	0	Caveolin-1	0,10	STAT3	105,110	Caveolin-1	STAT3	857	6774	Gene	Gene	arrests|amod|START_ENTITY arrests|dep|proliferation proliferation|nmod|cells cells|nmod|inhibition inhibition|nmod|signaling signaling|compound|END_ENTITY	Caveolin-1 silencing arrests the proliferation of metastatic lung_cancer cells through the inhibition of STAT3 signaling .
16568240	0	Caveolin-1	0,10	TCP-1	48,53	Caveolin-1	TCP-1	857	6950	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin-1 interacts with the chaperone complex TCP-1 and modulates its protein folding activity .
21641995	0	Caveolin-1	0,10	TGF-b1	21,27	Caveolin-1	TGF-b1	12389(Tax:10090)	21803(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Caveolin-1 modulates TGF-b1 signaling in cardiac_remodeling .
26159107	0	Caveolin-1	23,33	TNF-Alpha	10,19	Caveolin-1	TNF-Alpha	857	7124	Gene	Gene	Expression|compound|START_ENTITY Effect|nmod|Expression Effect|nmod|END_ENTITY	Effect of TNF-Alpha on Caveolin-1 Expression and Insulin Signaling During Adipocyte Differentiation and in Mature Adipocytes .
11112773	0	Caveolin-1	0,10	TRAF2	27,32	Caveolin-1	TRAF2	857	7186	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors .
21826216	0	Caveolin-1	0,10	VEGF	107,111	Caveolin-1	VEGF	857	7422	Gene	Gene	plays|nsubj|START_ENTITY plays|advcl|inhibiting inhibiting|dobj|differentiation differentiation|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway .
11278309	0	Caveolin-1	0,10	androgen_receptor	26,43	Caveolin-1	androgen receptor	857	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin-1 interacts with androgen_receptor .
21172357	0	Caveolin-1	0,10	angiotensin_II	112,126	Caveolin-1	angiotensin II	857	183	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Caveolin-1 negatively regulates a metalloprotease-dependent epidermal_growth_factor_receptor transactivation by angiotensin_II .
15769846	0	Caveolin-1	0,10	cathepsin_B	55,66	Caveolin-1	cathepsin B	857	1508	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Caveolin-1 mediates the expression and localization of cathepsin_B , pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal_carcinoma cells .
21172357	0	Caveolin-1	0,10	epidermal_growth_factor_receptor	60,92	Caveolin-1	epidermal growth factor receptor	857	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transactivation transactivation|compound|END_ENTITY	Caveolin-1 negatively regulates a metalloprotease-dependent epidermal_growth_factor_receptor transactivation by angiotensin_II .
10559241	0	Caveolin-1	0,10	estrogen_receptor_alpha	23,46	Caveolin-1	estrogen receptor alpha	857	2099	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	Caveolin-1 potentiates estrogen_receptor_alpha -LRB- ERalpha -RRB- signaling .
10749726	0	Caveolin-1	0,10	extracellular_signal-regulated_kinase	58,95	Caveolin-1	extracellular signal-regulated kinase	857	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Caveolin-1 regulates shear stress-dependent activation of extracellular_signal-regulated_kinase .
11114180	0	Caveolin-1	0,10	inducible_nitric_oxide_synthase	26,57	Caveolin-1	inducible nitric oxide synthase	857	4843	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Caveolin-1 down-regulates inducible_nitric_oxide_synthase via the proteasome pathway in human colon_carcinoma cells .
10598578	0	Caveolin-1	0,10	insulin_receptor	30,46	Caveolin-1	insulin receptor	857	24954(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Caveolin-1 interacts with the insulin_receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells .
25551286	0	Caveolin-1	0,10	langerin	31,39	Caveolin-1	langerin	857	50489	Gene	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Caveolin-1 mediated uptake via langerin restricts HIV-1_infection in human Langerhans cells .
19123976	0	Caveolin-1	0,10	membrane-type_1_matrix_metalloproteinase	20,60	Caveolin-1	membrane-type 1 matrix metalloproteinase	857	4323	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Caveolin-1 inhibits membrane-type_1_matrix_metalloproteinase activity .
21622714	0	Caveolin-1	0,10	stat3	100,105	Caveolin-1	stat3	857	6774	Gene	Gene	upregulation|amod|START_ENTITY mediates|nsubj|upregulation mediates|nmod|inhibition inhibition|amod|END_ENTITY	Caveolin-1 upregulation mediates suppression of primary breast_tumor growth and brain metastases by stat3 inhibition .
18434090	0	Caveolin-1	0,10	type_I_procollagen	63,81	Caveolin-1	type I procollagen	857	1278	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Caveolin-1 increases basal and TGF-beta1-induced expression of type_I_procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts .
26492081	0	Caveolin-2	60,70	Connexin_26	74,85	Caveolin-2	Connexin 26	12390(Tax:10090)	14619(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Mice Mice|amod|END_ENTITY	Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin_26 Deficient Mice .
19427337	0	Caveolin-2	0,10	STAT3	25,30	Caveolin-2	STAT3	858	6774	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin .
19108573	0	Caveolin-3	0,10	myostatin	21,30	Caveolin-3	myostatin	859	2660	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Caveolin-3 regulates myostatin signaling .
20015453	0	Caveolin-3	23,33	vitamin_D_receptor	67,85	Caveolin-3	vitamin D receptor	29161(Tax:10116)	24873(Tax:10116)	Gene	Gene	association|dep|START_ENTITY association|nmod|END_ENTITY	Membrane localization , Caveolin-3 association and rapid actions of vitamin_D_receptor in cardiac myocytes .
24329494	0	Caveolin_1	0,10	angiotensin_II	74,88	Caveolin 1	angiotensin II	12389(Tax:10090)	11606(Tax:10090)	Gene	Gene	critical|nsubj|START_ENTITY critical|nmod|formation formation|acl|induced induced|nmod|END_ENTITY	Caveolin_1 is critical for abdominal_aortic_aneurysm formation induced by angiotensin_II and inhibition of lysyl oxidase .
20610538	0	Caveolin_1	0,10	endothelial_nitric_oxide_synthase	45,78	Caveolin 1	endothelial nitric oxide synthase	857	4846	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Caveolin_1 is required for the activation of endothelial_nitric_oxide_synthase in response to 17beta-estradiol .
25520561	0	Cavin-3	15,22	Matrix_Metalloproteinase-9	23,49	Cavin-3	Matrix Metalloproteinase-9	112464	4318	Gene	Gene	Role|nmod|START_ENTITY Role|dep|Axis Axis|compound|END_ENTITY	A Role for the Cavin-3 / Matrix_Metalloproteinase-9 Signaling Axis in the Regulation of PMA-Activated Human HT1080 Fibrosarcoma Cell Neoplastic Phenotype .
25588833	0	Cavin3	0,6	cavin1	22,28	Cavin3	cavin1	112464	284119	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae .
22889834	0	Cb1	14,17	translin-associated_factor_X	74,102	Cb1	translin-associated factor X	1268	7257	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	Phospholipase Cb1 is linked to RNA interference of specific genes through translin-associated_factor_X .
17612558	0	Cbf5p	109,114	Gar1p	72,77	Cbf5p	Gar1p	850872(Tax:4932)	856489(Tax:4932)	Gene	Gene	mediating|nmod|START_ENTITY END_ENTITY|acl|mediating	The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p .
21121067	0	Cbfa-1	171,177	BMP-2	165,170	Cbfa-1	BMP-2	860	650	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Effect of high glucose levels on the calcification of vascular smooth muscle cells by inducing osteoblastic differentiation and intracellular calcium deposition via BMP-2 / Cbfa-1 pathway .
16636074	0	Cbfa-1	0,6	MMP-13	43,49	Cbfa-1	MMP-13	12393(Tax:10090)	17386(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	Cbfa-1 mediates nitric_oxide regulation of MMP-13 in osteoblasts .
18381576	0	Cbfa-1	27,33	Runx2	34,39	Cbfa-1	Runx2	860	860	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression and function of Cbfa-1 / Runx2 in thyroid_papillary_carcinoma cells .
21412826	0	Cbfa1	48,53	FAK	36,39	Cbfa1	FAK	12393(Tax:10090)	14083(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY affects|dobj|expression affects|nsubj|END_ENTITY	Integrin-associated tyrosine kinase FAK affects Cbfa1 expression .
12434156	0	Cbfbeta	0,7	Runx2	23,28	Cbfbeta	Runx2	12400(Tax:10090)	12393(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cbfbeta interacts with Runx2 and has a critical role in bone development .
11580836	0	Cbk1	104,108	Lre1	0,4	Cbk1	Lre1	855561(Tax:4932)	850306(Tax:4932)	Gene	Gene	kinase|amod|START_ENTITY inhibition|nmod|kinase chitinase|nmod|inhibition affects|xcomp|chitinase affects|nsubj|END_ENTITY	Lre1 affects chitinase expression , trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces_cerevisiae .
23954433	0	Cbk1	43,47	Lre1	0,4	Cbk1	Lre1	855561(Tax:4932)	850306(Tax:4932)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner .
19962308	0	Cbk1	0,4	Ssd1	43,47	Cbk1	Ssd1	855561(Tax:4932)	851887(Tax:4932)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control .
21339329	0	Cbk1	10,14	Ssd1	79,83	Cbk1	Ssd1	855561(Tax:4932)	851887(Tax:4932)	Gene	Gene	kinase|compound|START_ENTITY regulates|nsubj|kinase regulates|dobj|localization localization|nmod|END_ENTITY	The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1 .
10608804	0	Cbl	31,34	Crkl	20,24	Cbl	Crkl	12402(Tax:10090)	12929(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration .
7545163	0	Cbl	47,50	Crkl	0,4	Cbl	Crkl	867	1399	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubjpass|END_ENTITY	Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive_leukemia .
23665906	0	Cbl	32,35	E3_Ubiquitin_Ligase	12,31	Cbl	E3 Ubiquitin Ligase	867	158506	Gene	Gene	Proteins|compound|START_ENTITY Proteins|compound|END_ENTITY	The Role of E3_Ubiquitin_Ligase Cbl Proteins in b-Elemene Reversing Multi-Drug Resistance of Human Gastric_Adenocarcinoma Cells .
15475003	0	Cbl	22,25	EGFR	62,66	Cbl	EGFR	867	1956	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Direct interaction of Cbl with pTyr 1045 of the EGF_receptor -LRB- EGFR -RRB- is required to sort the EGFR to lysosomes for degradation .
8612729	0	Cbl	85,88	Fc_gamma_receptor	92,109	Cbl	Fc gamma receptor	867	2209	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fc_gamma_receptor signaling .
9890970	0	Cbl	20,23	Fyn	0,3	Cbl	Fyn	500985(Tax:10116)	25150(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl , a binding site for phosphatidylinositol 3-kinase .
11399323	0	Cbl	28,31	Grb2	37,41	Cbl	Grb2	867	2885	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Differential interaction of Cbl with Grb2 and CrkL in CD2-mediated NK cell activation .
17904548	0	Cbl	97,100	Grb2	0,4	Cbl	Grb2	867	2885	Gene	Gene	recruitment|nmod|START_ENTITY signaling|nmod|recruitment receptor/c-Kit|acl|signaling regulation|nmod|receptor/c-Kit mediates|dobj|regulation mediates|nsubj|END_ENTITY	Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl .
19546888	0	Cbl	0,3	JNK	25,28	Cbl	JNK	867	5599	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Cbl negatively regulates JNK activation and cell death .
9541596	0	Cbl	121,124	PI-3K	59,64	Cbl	PI-3K	867	5295	Gene	Gene	phosphorylation|nmod|START_ENTITY involves|dobj|phosphorylation involves|nsubj|activation activation|nmod|END_ENTITY	CD16-mediated activation of phosphatidylinositol-3_kinase -LRB- PI-3K -RRB- in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2 , Shc , pp36 and p85 PI-3K subunit .
12717426	0	Cbl	6,9	PLC_gamma_1	18,29	Cbl	PLC gamma 1	867	5335	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	70Z/3 Cbl induces PLC_gamma_1 activation in T lymphocytes via an alternate Lat - and Slp-76-independent signaling mechanism .
25285640	0	Cbl	0,3	SIRT2	30,35	Cbl	SIRT2	867	22933	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Cbl regulates the activity of SIRT2 .
10204582	0	Cbl	0,3	Src	28,31	Cbl	Src	867	6714	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	Cbl functions downstream of Src kinases in Fc_gamma_RI signaling in primary human macrophages .
10540342	0	Cbl	69,72	Syk	8,11	Cbl	Syk	100725041	100716985	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Role of Syk in Fc gamma receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C. Fcgamma receptors -LRB- FcgammaR -RRB- of guinea_pig neutrophils were ligated and anti-Cbl immunoprecipitates prepared therefrom were assayed for the associated protein tyrosine kinase activity , which increased upon ligation of FcgammaR .
10617633	0	Cbl	26,29	Syk	74,77	Cbl	Syk	867	6850	Gene	Gene	domain|nmod|START_ENTITY essential|nsubj|domain essential|nmod|regulation regulation|nmod|kinase kinase|compound|END_ENTITY	The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase .
19419964	0	Cbl	114,117	Syk	0,3	Cbl	Syk	867	6850	Gene	Gene	activity|nmod|START_ENTITY function|nmod|activity regulates|dobj|function regulates|nsubj|tyrosine tyrosine|compound|END_ENTITY	Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl .
9880513	0	Cbl	118,121	Syk	79,82	Cbl	Syk	867	6850	Gene	Gene	substrates|dobj|START_ENTITY substrates|nsubj|association association|nmod|END_ENTITY	Phosphorylation - and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells .
12771181	0	Cbl-b	0,5	B_cell_antigen_receptor	27,50	Cbl-b	B cell antigen receptor	208650(Tax:10090)	110279(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cbl-b negatively regulates B_cell_antigen_receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk .
19801520	0	Cbl-b	24,29	CD4	95,98	Cbl-b	CD4	868	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expansion expansion|nmod|activity activity|nmod|cells cells|compound|END_ENTITY	The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells .
21248249	0	Cbl-b	24,29	CD4	59,62	Cbl-b	CD4	208650(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Visualizing|dobj|role Visualizing|nmod|control control|nmod|cells cells|compound|END_ENTITY	Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes .
22884358	0	Cbl-b	17,22	CD4	83,86	Cbl-b	CD4	868	920	Gene	Gene	Up-regulation|nmod|START_ENTITY associated|nsubjpass|Up-regulation associated|nmod|inhibition inhibition|nmod|subsets subsets|compound|END_ENTITY	Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4 + T-cell subsets .
25560411	0	Cbl-b	20,25	CD4	51,54	Cbl-b	CD4	208650(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
18025165	0	Cbl-b	0,5	CD8	89,92	Cbl-b	CD8	868	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|compound|END_ENTITY	Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity .
25560411	0	Cbl-b	20,25	E3_Ubiquitin_Ligase	0,19	Cbl-b	E3 Ubiquitin Ligase	208650(Tax:10090)	68350(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
15308098	0	Cbl-b	42,47	E3_ubiquitin_ligase	22,41	Cbl-b	E3 ubiquitin ligase	208650(Tax:10090)	68350(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Essential role of the E3_ubiquitin_ligase Cbl-b in T cell anergy induction .
26300253	0	Cbl-b	36,41	E3_ubiquitin_ligase	16,35	Cbl-b	E3 ubiquitin ligase	868	158506	Gene	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|END_ENTITY	-LSB- Suppression of E3_ubiquitin_ligase Cbl-b in interleukin-1 signaling -RSB- .
20439537	0	Cbl-b	60,65	Foxp3	86,91	Cbl-b	Foxp3	208650(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells .
25560411	0	Cbl-b	20,25	Foxp3	104,109	Cbl-b	Foxp3	208650(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|nmod|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
20639876	0	Cbl-b	139,144	MyD88	120,125	Cbl-b	MyD88	208650(Tax:10090)	17874(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b .
26112603	0	Cbl-b	20,25	ORMDL3	43,49	Cbl-b	ORMDL3	868	94103	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation .
22763434	0	Cbl-b	20,25	Pten	36,40	Cbl-b	Pten	208650(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	E3_ubiquitin_ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity .
19546233	0	Cbl-b	17,22	insulin-like_growth_factor_1	51,79	Cbl-b	insulin-like growth factor 1	208650(Tax:10090)	16000(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Ubiquitin_ligase Cbl-b is a negative regulator for insulin-like_growth_factor_1 signaling during muscle_atrophy caused by unloading .
26300253	0	Cbl-b	36,41	interleukin-1	45,58	Cbl-b	interleukin-1	868	3552	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Suppression of E3_ubiquitin_ligase Cbl-b in interleukin-1 signaling -RSB- .
20537373	0	Cbln1	62,67	GluRdelta2	30,40	Cbln1	GluRdelta2	869	14804(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum .
20395510	0	Cbln1	0,5	glutamate_receptor_delta2	32,57	Cbln1	glutamate receptor delta2	12404(Tax:10090)	14804(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Cbln1 is a ligand for an orphan glutamate_receptor_delta2 , a bidirectional synapse organizer .
10964938	0	Cbln3	0,5	precerebellin	29,42	Cbln3	precerebellin	56410(Tax:10090)	12404(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Cbln3 , a novel member of the precerebellin family that binds specifically to Cbln1 .
19874196	0	Cbp	0,3	Csk	19,22	Cbp	Csk	1387	1445	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	Cbp recruitment of Csk into lipid rafts is critical to c-Src_kinase activity and bone resorption in osteoclasts .
22989713	0	Cbp80	70,75	Sgf11	17,22	Cbp80	Sgf11	44409(Tax:7227)	40035(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila .
25801166	0	Cbx2	0,4	PRC1	13,17	Cbx2	PRC1	12416(Tax:10090)	233406(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner .
25398592	0	Cbx8	48,52	Insulin-Like_Growth_Factor-1	0,28	Cbx8	Insulin-Like Growth Factor-1	57332	3479	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Insulin-Like_Growth_Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon_Cancer Cell Apoptosis .
8676862	0	CcdB	115,119	LetD	109,113	CcdB	LetD	6276084(Tax:526563)	6382275(Tax:562)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Co-induction of DNA relaxation and synthesis of DnaK and GroEL proteins in Escherichia_coli by expression of LetD -LRB- CcdB -RRB- protein , an inhibitor of DNA gyrase encoded by the F factor .
23449887	0	Ccdc80	43,49	steroid-sensitive_gene-1	18,42	Ccdc80	steroid-sensitive gene-1	151887	151887	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of steroid-sensitive_gene-1 / Ccdc80 as a JAK2-binding protein .
16337661	0	Cce1p	71,76	Msh1p	29,34	Cce1p	Msh1p	853858(Tax:4932)	856520(Tax:4932)	Gene	Gene	contributions|dep|START_ENTITY contributions|nmod|END_ENTITY	Overlapping contributions of Msh1p and putative recombination proteins Cce1p , Din7p , and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces_cerevisiae .
17474992	0	Ccl12	160,165	CCL2	143,147	Ccl12	CCL2	20293(Tax:10090)	20296(Tax:10090)	Gene	Gene	monocyte_chemoattractant_protein-1|appos|START_ENTITY monocyte_chemoattractant_protein-1|appos|END_ENTITY	Hypoxia-inducible factor-1 -LRB- HIF-1 -RRB- is involved in the regulation of hypoxia-stimulated expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 / CCL2 -RRB- and MCP-5 -LRB- Ccl12 -RRB- in astrocytes .
19303953	0	Ccl20	73,78	Toll-like_receptor_5	0,20	Ccl20	Toll-like receptor 5	20297(Tax:10090)	53791(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Toll-like_receptor_5 - and lymphotoxin_beta_receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics .
18289368	0	Ccn3	135,139	Nov	130,133	Ccn3	Nov	18133(Tax:10090)	18133(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Abnormal skeletal and cardiac development , cardiomyopathy , muscle_atrophy and cataracts in mice with a targeted disruption of the Nov -LRB- Ccn3 -RRB- gene .
15215197	0	Ccna1	46,51	cyclin_A1	30,39	Ccna1	cyclin A1	12427(Tax:10090)	12427(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Distinct regions of the mouse cyclin_A1 gene , Ccna1 , confer male germ-cell specific expression and enhancer function .
16547599	0	Ccnd1	20,25	INS-1	73,78	Ccnd1	INS-1	58919(Tax:10116)	24505(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Upregulation of rat Ccnd1 gene by exendin-4 in pancreatic beta cell line INS-1 : interaction of early growth response-1 with cis-regulatory element .
12126640	0	Ccr2	0,4	CCL2	34,38	Ccr2	CCL2	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|level level|nmod|END_ENTITY	Ccr2 regulates the level of MCP-1 / CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen .
12126640	0	Ccr2	0,4	MCP-1	28,33	Ccr2	MCP-1	12772(Tax:10090)	20296(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|level level|nmod|CCL2 CCL2|compound|END_ENTITY	Ccr2 regulates the level of MCP-1 / CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen .
26684629	0	Ccr4	70,74	Il-4	76,80	Ccr4	Il-4	1233	3565	Gene	Gene	Il-13|compound|START_ENTITY Il-13|dep|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
7890169	0	Cct	11,14	Cctq	21,25	Cct	Cctq	907	10694	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The eighth Cct gene , Cctq , encoding the theta subunit of the cytosolic chaperonin containing TCP-1 .
8661059	0	Cct4	118,122	chaperonin_containing_TCP-1	89,116	Cct4	chaperonin containing TCP-1	12464(Tax:10090)	12464(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin_containing_TCP-1 -LRB- Cct4 -RRB- gene to proximal chromosome 11 .
7890169	0	Cctq	21,25	Cct	11,14	Cctq	Cct	10694	907	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The eighth Cct gene , Cctq , encoding the theta subunit of the cytosolic chaperonin containing TCP-1 .
25168844	0	Cd16	54,58	CD14	23,27	Cd16	CD14	2214	929	Gene	Gene	Monocytes|nmod|START_ENTITY Monocytes|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
25168844	0	Cd16	54,58	CD16	28,32	Cd16	CD16	2214	2214	Gene	Gene	Monocytes|nmod|START_ENTITY Monocytes|compound|END_ENTITY	A Modulatory Effect of CD14 + CD16 + + Monocytes on CD14 + + Cd16 - Monocytes : A Possible Explanation of Monocyte Alterations in Systemic_Lupus_Erythematosus .
10190043	0	Cd2	60,63	butyrylcholinesterase	35,56	Cd2	butyrylcholinesterase	101106727	101102112	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Inhibition kinetics of human serum butyrylcholinesterase by Cd2 + , Zn2 + and Al3 + : comparison of the effects of metal ions on cholinesterases .
20400699	0	Cd247	27,32	Cd3_zeta	17,25	Cd247	Cd3 zeta	12503(Tax:10090)	12503(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in the Cd3_zeta -LRB- Cd247 -RRB- gene correlates with altered T cell activation and is associated with autoimmune_diabetes .
26684629	0	Cd25	4,8	Cd4	0,3	Cd25	Cd4	3559	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
26684629	0	Cd25	4,8	Foxp3	9,14	Cd25	Foxp3	3559	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
18242221	0	Cd36	31,35	LXR	58,61	Cd36	LXR	12491(Tax:10090)	22259(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Hepatic fatty_acid transporter Cd36 is a common target of LXR , PXR , and PPARgamma in promoting steatosis .
14524479	0	Cd38	0,4	Cd8	19,22	Cd38	Cd8	952	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Cd38 expression on Cd8 + T cells in Human_immunodeficiency_virus_1-positive adults treated with HAART .
10636863	1	Cd38	72,76	Lck	133,136	Cd38	Lck	952	3932	Gene	Gene	transduces|nsubj|START_ENTITY transduces|nmod|END_ENTITY	Cd38 transduces T cell activation signals through associated Lck .
20400699	0	Cd3_zeta	17,25	Cd247	27,32	Cd3 zeta	Cd247	12503(Tax:10090)	12503(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the Cd3_zeta -LRB- Cd247 -RRB- gene correlates with altered T cell activation and is associated with autoimmune_diabetes .
24836425	0	Cd4	108,111	CD8	115,118	Cd4	CD8	920	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4 -LRB- + -RRB- T cell fate and interact with Runx3 to silence Cd4 in CD8 -LRB- + -RRB- T cells .
26684629	0	Cd4	0,3	Cd25	4,8	Cd4	Cd25	920	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
26684629	0	Cd4	0,3	Foxp3	9,14	Cd4	Foxp3	920	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
21680714	0	Cd44	76,80	c-Met	0,5	Cd44	c-Met	12505(Tax:10090)	17295(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY compensate|nmod|mice coreceptor|acl|compensate recruits|nmod|coreceptor recruits|nsubj|END_ENTITY	c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice .
18178847	0	Cd55	107,111	CD4	46,49	Cd55	CD4	13136(Tax:10090)	12504(Tax:10090)	Gene	Gene	identifies|dobj|START_ENTITY identifies|nsubj|analysis analysis|nmod|Cells Cells|compound|END_ENTITY	Genome-wide microarray expression analysis of CD4 + T Cells from nonobese diabetic congenic mice identifies Cd55 -LRB- Daf1 -RRB- and Acadl as candidate genes for type_1_diabetes .
22918646	0	Cd59a	79,84	Complement_factor_H	0,19	Cd59a	Complement factor H	12509(Tax:10090)	12628(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Complement_factor_H deficiency results in decreased neuroretinal expression of Cd59a in aged mice .
14524479	0	Cd8	19,22	Cd38	0,4	Cd8	Cd38	925	952	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Cd38 expression on Cd8 + T cells in Human_immunodeficiency_virus_1-positive adults treated with HAART .
16491076	0	Cd8	42,45	MAZR	103,107	Cd8	MAZR	925	23598	Gene	Gene	recruitment|amod|START_ENTITY regulation|nmod|recruitment regulation|nmod|END_ENTITY	Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR .
22518840	0	CdGAP	74,79	Cdc42	41,46	CdGAP	Cdc42	57514	998	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	A stretch of polybasic residues mediates Cdc42 GTPase-activating protein -LRB- CdGAP -RRB- binding to phosphatidylinositol_3 ,4,5 - trisphosphate and regulates its GAP activity .
9786927	0	CdGAP	0,5	Cdc42	58,63	CdGAP	Cdc42	57514	998	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	CdGAP , a novel proline-rich GTPase-activating protein for Cdc42 and Rac .
16860736	0	CdGAP	0,5	actopaxin	22,31	CdGAP	actopaxin	57514	55742	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility .
20808892	0	Cdc13	57,62	Sgs1	81,85	Cdc13	Sgs1	851306(Tax:4932)	855228(Tax:4932)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1 , Exo1 , and Rad9 .
9042864	0	Cdc13	108,113	Stn1	0,4	Cdc13	Stn1	851306(Tax:4932)	851655(Tax:4932)	Gene	Gene	implicated|nmod|START_ENTITY implicated|nsubjpass|END_ENTITY	Stn1 , a new Saccharomyces_cerevisiae protein , is implicated in telomere size regulation in association with Cdc13 .
24626187	0	Cdc14	0,5	Yen1	46,50	Cdc14	Yen1	850585(Tax:4932)	856764(Tax:4932)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Cdc14 targets the Holliday junction resolvase Yen1 to the nucleus in early anaphase .
17172867	0	Cdc14A	6,12	Cdc25A	46,52	Cdc14A	Cdc25A	8556	993	Gene	Gene	reverses|nsubj|START_ENTITY reverses|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320 .
20956543	0	Cdc14A	6,12	Cdc25A	63,69	Cdc14A	Cdc25A	8556	993	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B .
23051732	0	Cdc14A	6,12	Wee1	23,27	Cdc14A	Wee1	8556	7465	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation .
20368335	0	Cdc2	54,58	Cdc25A	22,28	Cdc2	Cdc25A	983	993	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Pro-apoptotic role of Cdc25A : activation of cyclin_B1 / Cdc2 by the Cdc25A C-terminal domain .
20368335	0	Cdc2	54,58	Cdc25A	66,72	Cdc2	Cdc25A	983	993	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Pro-apoptotic role of Cdc25A : activation of cyclin_B1 / Cdc2 by the Cdc25A C-terminal domain .
7787247	0	Cdc2	82,86	Cdc25_phosphatase	46,63	Cdc2	Cdc25 phosphatase	379785(Tax:8355)	494708(Tax:8355)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Phosphorylation and activation of the Xenopus Cdc25_phosphatase in the absence of Cdc2 and Cdk2 kinase activity .
10488332	0	Cdc2	0,4	Crb2	24,28	Cdc2	Crb2	983	286204	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cdc2 phosphorylation of Crb2 is required for reestablishing cell cycle progression after the damage checkpoint .
17276914	0	Cdc2	11,15	Emi2	49,53	Cdc2	Emi2	983	286151	Gene	Gene	regulation|amod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	A role for Cdc2 - and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest .
9001210	0	Cdc2	52,56	Myt1_kinase	10,21	Cdc2	Myt1 kinase	983	9088	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The human Myt1_kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex .
8666924	0	Cdc2	72,76	RHAMM	28,33	Cdc2	RHAMM	983	3161	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Soluble hyaluronan receptor RHAMM induces mitotic_arrest by suppressing Cdc2 and cyclin_B1 expression .
11461916	0	Cdc2	27,31	RINGO	44,49	Cdc2	RINGO	379785(Tax:8355)	398012(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins .
22371530	0	Cdc2	28,32	Vimentin	0,8	Cdc2	Vimentin	983	7431	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth via b1-integrin activation .
9578617	0	Cdc2	31,35	cyclin_A	22,30	Cdc2	cyclin A	983	890	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	In vivo regulation of cyclin_A / Cdc2 and cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish .
16102754	0	Cdc2	68,72	cyclin_B1	58,67	Cdc2	cyclin B1	12534(Tax:10090)	268697(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Kr __ ppel-like_factor_5 promotes mitosis by activating the cyclin_B1 / Cdc2 complex during oncogenic Ras-mediated transformation .
21918689	0	Cdc2	18,22	cyclin_B1	8,17	Cdc2	cyclin B1	983	891	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Role of cyclin_B1 / Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast_cancer cells treated with nocodazole .
11445251	0	Cdc2	0,4	nucleolin	24,33	Cdc2	nucleolin	983	4691	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer 's _ disease pathology .
12049736	0	Cdc2	38,42	p34	62,65	Cdc2	p34	983	902	Gene	Gene	tyrosine-15|nmod|START_ENTITY Phosphorylation|nmod|tyrosine-15 inhibits|nsubj|Phosphorylation inhibits|dobj|activation activation|amod|END_ENTITY	Phosphorylation on tyrosine-15 of p34 -LRB- Cdc2 -RRB- by ErbB2 inhibits p34 -LRB- Cdc2 -RRB- activation and is involved in resistance to taxol-induced apoptosis .
12049736	0	Cdc2	66,70	p34	34,37	Cdc2	p34	983	902	Gene	Gene	activation|appos|START_ENTITY inhibits|dobj|activation inhibits|nsubj|Phosphorylation Phosphorylation|nmod|tyrosine-15 tyrosine-15|nmod|Cdc2 Cdc2|amod|END_ENTITY	Phosphorylation on tyrosine-15 of p34 -LRB- Cdc2 -RRB- by ErbB2 inhibits p34 -LRB- Cdc2 -RRB- activation and is involved in resistance to taxol-induced apoptosis .
12049736	0	Cdc2	66,70	p34	62,65	Cdc2	p34	983	902	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Phosphorylation on tyrosine-15 of p34 -LRB- Cdc2 -RRB- by ErbB2 inhibits p34 -LRB- Cdc2 -RRB- activation and is involved in resistance to taxol-induced apoptosis .
9715268	0	Cdc2	14,18	p53	0,3	Cdc2	p53	983	7157	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p53 regulates Cdc2 independently of inhibitory phosphorylation to reinforce radiation-induced G2_arrest in human cells .
16600213	0	Cdc20	52,57	BubR1	97,102	Cdc20	BubR1	991	701	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|domain domain|nmod|END_ENTITY	Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1 .
19154723	0	Cdc20	78,83	BubR1	0,5	Cdc20	BubR1	991	701	Gene	Gene	APC/C|appos|START_ENTITY acts|nmod|APC/C acts|nsubj|terminus terminus|compound|END_ENTITY	BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C -LRB- Cdc20 -RRB- in interphase .
20421417	0	Cdc20	15,20	BubR1	49,54	Cdc20	BubR1	34968(Tax:7227)	35522(Tax:7227)	Gene	Gene	Recruitment|nmod|START_ENTITY requires|nsubj|Recruitment requires|dobj|END_ENTITY	Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila_melanogaster .
25482201	0	Cdc20	13,18	BubR1	35,40	Cdc20	BubR1	991	701	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing .
10647015	0	Cdc20	4,9	Pds1	75,79	Cdc20	Pds1	852762(Tax:4932)	851691(Tax:4932)	Gene	Gene	APC|appos|START_ENTITY promotes|nsubj|APC promotes|advcl|destroying destroying|dobj|END_ENTITY	APC -LRB- Cdc20 -RRB- promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5 .
11553328	0	Cdc20	66,71	Pds1	23,27	Cdc20	Pds1	852762(Tax:4932)	851691(Tax:4932)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner .
9501986	0	Cdc20	0,5	Pds1	66,70	Cdc20	Pds1	852762(Tax:4932)	851691(Tax:4932)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|proteolysis proteolysis|nmod|END_ENTITY	Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast .
17598981	0	Cdc20	52,57	RASSF1A	21,28	Cdc20	RASSF1A	991	11186	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The tumor suppressor RASSF1A does not interact with Cdc20 , an activator of the anaphase-promoting complex .
20053638	0	Cdc20	0,5	centromere_protein_F	70,90	Cdc20	centromere protein F	991	1063	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|degradation degradation|nmod|END_ENTITY	Cdc20 is required for the post-anaphase , KEN-dependent degradation of centromere_protein_F .
19273532	0	Cdc20	37,42	p53	19,22	Cdc20	p53	991	7157	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling .
8300560	1	Cdc24	97,102	Bem3	141,145	Cdc24	Bem3	851190(Tax:4932)	855988(Tax:4932)	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Catalysis of guanine_nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3 .
12582118	0	Cdc24	0,5	Cdc42	39,44	Cdc24	Cdc42	851190(Tax:4932)	850930(Tax:4932)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Cdc24 , the GDP-GTP exchange factor for Cdc42 , is required for invasive hyphal growth of Candida_albicans .
18378681	0	Cdc24	46,51	Cdc42	57,62	Cdc24	Cdc42	851190(Tax:4932)	850930(Tax:4932)	Gene	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Oligomerization regulates the localization of Cdc24 , the Cdc42 activator in Saccharomyces_cerevisiae .
16325503	0	Cdc24	130,135	Spa2	53,57	Cdc24	Spa2	851190(Tax:4932)	850639(Tax:4932)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|localization localization|nmod|END_ENTITY	Cdc42-dependent localization of polarisome component Spa2 to the incipient bud site is independent of the GDP/GTP exchange factor Cdc24 .
15657049	0	Cdc24	0,5	Ste5	57,61	Cdc24	Ste5	851190(Tax:4932)	851680(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|shuttling shuttling|nmod|END_ENTITY	Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces_cerevisiae .
16969075	0	Cdc25	99,104	H32	0,3	Cdc25	H32	995	126961	Gene	Gene	inhibiting|dobj|START_ENTITY inhibits|advcl|inhibiting inhibits|nsubj|END_ENTITY	H32 , a non-quinone_sulfone analog of vitamin_K3 , inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK .
17172867	0	Cdc25A	46,52	CDK1	22,26	Cdc25A	CDK1	993	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320 .
21252624	0	Cdc25A	14,20	CK1	0,3	Cdc25A	CK1	993	1452	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	CK1 targets Cdc25A for ubiquitin-mediated proteolysis under normal conditions and in response to checkpoint activation .
17172867	0	Cdc25A	46,52	Cdc14A	6,12	Cdc25A	Cdc14A	993	8556	Gene	Gene	phosphorylation|nmod|START_ENTITY reverses|dobj|phosphorylation reverses|nsubj|END_ENTITY	Human Cdc14A reverses CDK1 phosphorylation of Cdc25A on serines 115 and 320 .
20956543	0	Cdc25A	63,69	Cdc14A	6,12	Cdc25A	Cdc14A	993	8556	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B .
20368335	0	Cdc25A	22,28	Cdc2	54,58	Cdc25A	Cdc2	993	983	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Pro-apoptotic role of Cdc25A : activation of cyclin_B1 / Cdc2 by the Cdc25A C-terminal domain .
20368335	0	Cdc25A	66,72	Cdc2	54,58	Cdc25A	Cdc2	993	983	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Pro-apoptotic role of Cdc25A : activation of cyclin_B1 / Cdc2 by the Cdc25A C-terminal domain .
16216921	0	Cdc25A	23,29	Cdc25B	0,6	Cdc25A	Cdc25B	993	994	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin_B1-Cdk1 at the centrosome .
20228808	0	Cdc25A	74,80	Dub3	20,24	Cdc25A	Dub3	993	377630	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A .
10641570	0	Cdc25A	87,93	GM-CSF	15,21	Cdc25A	GM-CSF	993	1437	Gene	Gene	expression|nmod|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	The effects of GM-CSF , steel_factor and MIP-1alpha on the expression and activation of Cdc25A phosphatase in Mo7e cells .
18167338	0	Cdc25A	19,25	GSK-3_beta	0,10	Cdc25A	GSK-3 beta	993	2932	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	GSK-3_beta targets Cdc25A for ubiquitin-mediated proteolysis , and GSK-3_beta inactivation correlates with Cdc25A overproduction in human cancers .
22843495	0	Cdc25A	17,23	Hsp90	0,5	Cdc25A	Hsp90	993	3320	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic_carcinoma cells .
22705122	0	Cdc25A	16,22	Rock2	0,5	Cdc25A	Rock2	993	9475	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular_carcinoma cells .
16216921	0	Cdc25B	0,6	Cdc25A	23,29	Cdc25B	Cdc25A	994	993	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin_B1-Cdk1 at the centrosome .
20876571	0	Cdc25B	49,55	Cdk1	29,33	Cdc25B	Cdk1	994	983	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	WITHDRAWN : Survivin mediates Cdk1 activation via Cdc25B early in mitosis .
18237113	0	Cdc25B	80,86	Chk1	142,146	Cdc25B	Chk1	994	1111	Gene	Gene	pattern|nmod|START_ENTITY provides|nmod|pattern provides|parataxis|overlap overlap|nmod|kinases kinases|amod|END_ENTITY	NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo : full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro .
21242964	0	Cdc25B	0,6	Sp1	46,49	Cdc25B	Sp1	994	6667	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors .
23160377	0	Cdc25B	53,59	Sp1	89,92	Cdc25B	Sp1	994	6667	Gene	Gene	upregulation|nmod|START_ENTITY promotes|dobj|upregulation promotes|advcl|releasing releasing|dobj|END_ENTITY	Doxorubicin promotes transcriptional upregulation of Cdc25B in cancer cells by releasing Sp1 from the promoter .
21242964	0	Cdc25B	0,6	p53	34,37	Cdc25B	p53	994	7157	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors .
11896603	0	Cdc25C	0,6	PCNA	22,26	Cdc25C	PCNA	995	5111	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cdc25C interacts with PCNA at G2/M transition .
16356754	0	Cdc25C	112,118	Pim-1	38,43	Cdc25C	Pim-1	995	5292	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C .
11408585	0	Cdc25C	72,78	Plx1	21,25	Cdc25C	Plx1	398119(Tax:8355)	380481(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes .
21041626	0	Cdc25C	45,51	RSK2	37,41	Cdc25C	RSK2	398119(Tax:8355)	399376(Tax:8355)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation .
15574328	0	Cdc25C	37,43	p53	59,62	Cdc25C	p53	995	7157	Gene	Gene	downregulation|nmod|START_ENTITY mediated|nsubjpass|downregulation mediated|nmod|END_ENTITY	DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms : one involves direct binding to the cdc25C promoter .
7787247	0	Cdc25_phosphatase	46,63	Cdc2	82,86	Cdc25 phosphatase	Cdc2	494708(Tax:8355)	379785(Tax:8355)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Phosphorylation and activation of the Xenopus Cdc25_phosphatase in the absence of Cdc2 and Cdk2 kinase activity .
21073870	0	Cdc25p	86,92	Ras2	23,27	Cdc25p	Ras2	851019(Tax:4932)	855625(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Feedback regulation of Ras2 guanine_nucleotide exchange factor -LRB- Ras2-GEF -RRB- activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces_cerevisiae .
10698951	0	Cdc27	77,82	p21	129,132	Cdc27	p21	996	644914	Gene	Gene	interaction|nmod|START_ENTITY mediated|nsubj|interaction mediated|nmod|END_ENTITY	Essential interaction between the fission_yeast DNA polymerase delta subunit Cdc27 and Pcn1 -LRB- PCNA -RRB- mediated through a C-terminal p21 -LRB- Cip1 -RRB- - like PCNA binding motif .
12111552	0	Cdc28	24,29	Cdc37	35,40	Cdc28	Cdc37	852457(Tax:4932)	851746(Tax:4932)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical interaction of Cdc28 with Cdc37 in Saccharomyces_cerevisiae .
7753858	0	Cdc28	56,61	Cdc37	0,5	Cdc28	Cdc37	852457(Tax:4932)	851746(Tax:4932)	Gene	Gene	association|nmod|START_ENTITY required|nmod|association required|nsubjpass|END_ENTITY	Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins .
26176233	0	Cdc28	67,72	Gcn2	4,8	Cdc28	Gcn2	852457(Tax:4932)	851877(Tax:4932)	Gene	Gene	Regulator|nmod|START_ENTITY Regulator|nsubj|END_ENTITY	The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast .
8670805	0	Cdc28	92,97	Pkc1	69,73	Cdc28	Pkc1	852457(Tax:4932)	852169(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	A pathway in the yeast cell division cycle linking protein_kinase_C -LRB- Pkc1 -RRB- to activation of Cdc28 at START .
9753775	0	Cdc2a	96,101	ICK1	0,4	Cdc2a	ICK1	824036(Tax:3702)	816875(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ICK1 , a cyclin-dependent protein kinase inhibitor from Arabidopsis_thaliana interacts with both Cdc2a and CycD3 , and its expression is induced by abscisic_acid .
9716410	0	Cdc34	0,5	Swe1	92,96	Cdc34	Swe1	851624(Tax:4932)	853252(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|degradation degradation|nmod|END_ENTITY	Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1 .
12111552	0	Cdc37	35,40	Cdc28	24,29	Cdc37	Cdc28	851746(Tax:4932)	852457(Tax:4932)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical interaction of Cdc28 with Cdc37 in Saccharomyces_cerevisiae .
7753858	0	Cdc37	0,5	Cdc28	56,61	Cdc37	Cdc28	851746(Tax:4932)	852457(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|association association|nmod|END_ENTITY	Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins .
14701845	0	Cdc37	59,64	Cdk4	90,94	Cdc37	Cdk4	11140	1019	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Identification of a conserved sequence motif that promotes Cdc37 and cyclin_D1 binding to Cdk4 .
14627196	0	Cdc37	0,5	Hsp90	18,23	Cdc37	Hsp90	851746(Tax:4932)	855836(Tax:4932)	Gene	Gene	goes|nsubj|START_ENTITY goes|nmod|END_ENTITY	Cdc37 goes beyond Hsp90 and kinases .
23569206	0	Cdc37	0,5	Hsp90	41,46	Cdc37	Hsp90	11140	3320	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|END_ENTITY	Cdc37 -LRB- cell_division_cycle_37 -RRB- restricts Hsp90 -LRB- heat_shock_protein_90 -RRB- motility by interaction with N-terminal and middle domain binding sites .
19269974	0	Cdc37	0,5	Ryk	16,19	Cdc37	Ryk	11140	6259	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular_domain .
11085988	0	Cdc37	32,37	androgen_receptor	47,64	Cdc37	androgen receptor	11140	367	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of human Cdc37 with the androgen_receptor but not with the glucocorticoid_receptor .
23281476	0	Cdc37	43,48	androgen_receptor	94,111	Cdc37	androgen receptor	11140	367	Gene	Gene	interaction|nmod|START_ENTITY promotes|nsubj|interaction promotes|dobj|activity activity|compound|END_ENTITY	Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen_receptor activity and prostate_cancer growth .
19897738	0	Cdc4	159,163	Tec1	87,91	Cdc4	Tec1	850539(Tax:4932)	852377(Tax:4932)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Multisite phosphorylation of the Saccharomyces_cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo .
16443932	0	Cdc42	29,34	Apolipoprotein_A-I	0,18	Cdc42	Apolipoprotein A-I	998	335	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Apolipoprotein_A-I activates Cdc42 signaling through the ABCA1 transporter .
11157975	0	Cdc42	129,134	Arp2/3	88,94	Cdc42	Arp2/3	998	10097;10096	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	A novel neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- binding protein , WISH , induces Arp2/3 complex activation independent of Cdc42 .
17145773	0	Cdc42	21,26	Asef2	0,5	Asef1	Asef2	50649	221178	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element .
17726059	0	Cdc42	0,5	Bazooka	25,32	Cdc42	Bazooka	32981(Tax:7227)	32703(Tax:7227)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC .
25002677	0	Cdc42	15,20	Bud3	0,4	Cdc42	Bud3	850930(Tax:4932)	850345(Tax:4932)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Bud3 activates Cdc42 to establish a proper growth site in budding yeast .
25185742	0	Cdc42	0,5	CCN2	35,39	Cdc42	CCN2	998	1490	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Cdc42 and p190RhoGAP activation by CCN2 regulates cell spreading and polarity and induces actin disassembly in migrating keratinocytes .
16714282	0	Cdc42	32,37	Caveolin-1	0,10	Cdc42	Caveolin-1	998	857	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Caveolin-1 functions as a novel Cdc42 guanine_nucleotide dissociation inhibitor in pancreatic beta-cells .
22518840	0	Cdc42	41,46	CdGAP	74,79	Cdc42	CdGAP	998	57514	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A stretch of polybasic residues mediates Cdc42 GTPase-activating protein -LRB- CdGAP -RRB- binding to phosphatidylinositol_3 ,4,5 - trisphosphate and regulates its GAP activity .
9786927	0	Cdc42	58,63	CdGAP	0,5	Cdc42	CdGAP	998	57514	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	CdGAP , a novel proline-rich GTPase-activating protein for Cdc42 and Rac .
12582118	0	Cdc42	39,44	Cdc24	0,5	Cdc42	Cdc24	850930(Tax:4932)	851190(Tax:4932)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Cdc24 , the GDP-GTP exchange factor for Cdc42 , is required for invasive hyphal growth of Candida_albicans .
18378681	0	Cdc42	57,62	Cdc24	46,51	Cdc42	Cdc24	850930(Tax:4932)	851190(Tax:4932)	Gene	Gene	activator|amod|START_ENTITY END_ENTITY|appos|activator	Oligomerization regulates the localization of Cdc24 , the Cdc42 activator in Saccharomyces_cerevisiae .
22461490	0	Cdc42	11,16	DOCK8	0,5	Cdc42	DOCK8	998	81704	Gene	Gene	activator|amod|START_ENTITY activator|nsubj|END_ENTITY	DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses .
16740995	0	Cdc42	57,62	Endothelin_1	0,12	Cdc42	Endothelin 1	998	1906	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Endothelin_1 stimulates beta1Pix-dependent activation of Cdc42 through the G -LRB- salpha -RRB- pathway .
15743413	0	Cdc42	88,93	FGD1	130,134	Cdc42	FGD1	998	2245	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	The FWD1/beta-TrCP-mediated degradation pathway establishes a ` turning off switch ' of a Cdc42 guanine_nucleotide exchange factor , FGD1 .
20045932	0	Cdc42	96,101	FGD1	138,142	Cdc42	FGD1	998	2245	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine_nucleotide exchange factor , FGD1 .
16581976	0	Cdc42	110,115	GEFmeso	41,48	Cdc42	GEFmeso	32981(Tax:7227)	37134(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Novel guanine_nucleotide exchange factor GEFmeso of Drosophila_melanogaster interacts with Ral and Rho GTPase Cdc42 .
12610628	0	Cdc42	0,5	GSK-3beta	16,25	Cdc42	GSK-3beta	64465(Tax:10116)	84027(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cdc42 regulates GSK-3beta and adenomatous_polyposis_coli to control cell polarity .
18575765	0	Cdc42	0,5	ID4	73,76	Cdc42	ID4	998	3400	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Cdc42 is highly expressed in colorectal_adenocarcinoma and downregulates ID4 through an epigenetic mechanism .
20493814	0	Cdc42	101,106	INF2	11,15	Cdc42	INF2	403934(Tax:9615)	490877(Tax:9615)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2 .
9368021	0	Cdc42	70,75	IQGAP1	49,55	Cdc42	IQGAP1	532712(Tax:9913)	104968536	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Regulation of cross-linking of actin filament by IQGAP1 , a target for Cdc42 .
26306570	0	Cdc42	53,58	JAM-A	0,5	Cdc42	JAM-A	998	50848	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis .
22589722	0	Cdc42	64,69	LMP1	27,31	Cdc42	LMP1	998	9260	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Epstein-Barr_virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal_carcinoma cells .
11035933	0	Cdc42	20,25	Laminin-1	0,9	Cdc42	Laminin-1	64465(Tax:10116)	316758(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Laminin-1 activates Cdc42 in the mechanism of laminin-1-mediated neurite outgrowth .
15728253	0	Cdc42	0,5	MMP-1	20,25	Cdc42	MMP-1	998	4312	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway .
14744859	0	Cdc42	81,86	MgcRacGAP	55,64	Cdc42	MgcRacGAP	998	29127	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase .
20730103	0	Cdc42	0,5	N-WASP	23,29	Cdc42	N-WASP	998	8976	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation , vesicle formation and vesicle_motility : implications for endocytosis .
21844200	0	Cdc42	17,22	Niemann-Pick_C1-like_1	38,60	Cdc42	Niemann-Pick C1-like 1	12540(Tax:10090)	237636(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The small GTPase Cdc42 interacts with Niemann-Pick_C1-like_1 -LRB- NPC1L1 -RRB- and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner .
20631255	0	Cdc42	0,5	PAK4	86,90	Cdc42	PAK4	998	10298	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B .
25475687	0	Cdc42	41,46	PICK1	0,5	Cdc42	PICK1	998	9463	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	PICK1 links AMPA receptor stimulation to Cdc42 .
16930532	0	Cdc42	0,5	PKCepsilon	21,31	Cdc42	PKCepsilon	998	5581	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Cdc42 is involved in PKCepsilon - and delta-induced neurite outgrowth and stress fibre dismantling .
14744859	0	Cdc42	81,86	PRC1	41,45	Cdc42	PRC1	998	9055	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase .
10934474	0	Cdc42	75,80	Par6	26,30	Cdc42	Par6	174233(Tax:6239)	173137(Tax:6239)	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 .
12531901	0	Cdc42	44,49	RICS	0,4	Cdc42	RICS	998	9743	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	RICS , a novel GTPase-activating protein for Cdc42 and Rac1 , is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling .
17107954	0	Cdc42	86,91	Rac-1	80,85	Cdc42	Rac-1	998	5879	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Phosphorylation of the LFA-1 integrin beta2-chain on Thr-758 leads to adhesion , Rac-1 / Cdc42 activation , and stimulation of CD69 expression in human T cells .
22796473	0	Cdc42	67,72	Rac-1	61,66	Cdc42	Rac-1	998	5879	Gene	Gene	acting|dep|START_ENTITY acting|nmod|GTPases GTPases|appos|END_ENTITY	Desmoglein_3 acting as an upstream regulator of Rho GTPases , Rac-1 / Cdc42 in the regulation of actin organisation and dynamics .
14653992	0	Cdc42	43,48	S6K1	63,67	Cdc42	S6K1	998	6198	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1 .
24003235	0	Cdc42	39,44	SNX26	0,5	Cdc42	SNX26	998	115703	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	SNX26 , a GTPase-activating protein for Cdc42 , interacts with PSD-95 protein and is involved in activity-dependent dendritic spine formation in mature neurons .
15075243	0	Cdc42	70,75	Smad7	0,5	Cdc42	Smad7	998	4092	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42 .
15561766	0	Cdc42	42,47	TNFalpha	0,8	Cdc42	TNFalpha	12540(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	TNFalpha induces sequential activation of Cdc42 - and p38/p53-dependent pathways that antagonistically regulate filopodia formation .
17302440	0	Cdc42	46,51	WASP	27,31	Cdc42	WASP	998	7454	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of WASP and N-WASP by Cdc42 , Rac1 , Nck , and PI -LRB- 4,5 -RRB- P2 .
19741094	0	Cdc42	0,5	Wiskott-Aldrich_syndrome_protein	102,134	Cdc42	Wiskott-Aldrich syndrome protein	998	7454	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Cdc42 regulates Fc_gamma_receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich_syndrome_protein -LRB- WASP -RRB- and neural-WASP .
24220306	0	Cdc42	105,110	Wnt5b	0,5	Cdc42	Wnt5b	998	81029	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Wnt5b promotes the cell motility essential for metastasis of oral_squamous_cell_carcinoma through active Cdc42 and RhoA .
12729560	0	Cdc42	71,76	Xfz7	56,60	Cdc42	Xfz7	379055(Tax:8355)	378787(Tax:8355)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Activation of Gbetagamma signaling downstream of Wnt-11 / Xfz7 regulates Cdc42 activity during Xenopus gastrulation .
12172552	0	Cdc42	18,23	Zizimin1	0,8	Cdc42	Zizimin1	998	23348	Gene	Gene	activator|amod|START_ENTITY END_ENTITY|appos|activator	Zizimin1 , a novel Cdc42 activator , reveals a new GEF domain for Rho proteins .
10473551	0	Cdc42	0,5	beta-catenin	55,67	Cdc42	beta-catenin	12540(Tax:10090)	12387(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin .
16215999	0	Cdc42	0,5	brain_derived_neurotrophic_factor	89,122	Cdc42	brain derived neurotrophic factor	998	627	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	Cdc42 participates in the regulation of ADF/cofilin and retinal growth cone filopodia by brain_derived_neurotrophic_factor .
23696594	0	Cdc42	44,49	cell-division_cycle_42	20,42	Cdc42	cell-division cycle 42	998	998	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Decreased levels of cell-division_cycle_42 -LRB- Cdc42 -RRB- protein in peripheral lymphocytes from ischaemic_stroke patients are associated with Golgi apparatus function .
21165582	0	Cdc42	109,114	chemokine_receptor_7	14,34	Cdc42	chemokine receptor 7	998	1236	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	CCL19-induced chemokine_receptor_7 activates the phosphoinositide-3_kinase-mediated invasive pathway through Cdc42 in metastatic squamous_cell_carcinoma_of_the_head_and_neck .
18045906	0	Cdc42	0,5	cofilin	16,23	Cdc42	cofilin	998	1072	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cdc42 regulates cofilin during the establishment of neuronal polarity .
11290522	0	Cdc42	0,5	cyclin_D1	31,40	Cdc42	cyclin D1	532712(Tax:9913)	524530(Tax:9913)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Cdc42 , but not RhoA , regulates cyclin_D1 expression in bovine tracheal myocytes .
11799118	0	Cdc42	4,9	epidermal_growth_factor_receptor	74,106	Cdc42	epidermal growth factor receptor	998	1956	Gene	Gene	ACK2|amod|START_ENTITY interacts|nsubj|ACK2 interacts|nmod|sorting_nexin_9 sorting_nexin_9|acl|regulate regulate|dobj|degradation degradation|compound|END_ENTITY	The Cdc42 target ACK2 interacts with sorting_nexin_9 -LRB- SH3PX1 -RRB- to regulate epidermal_growth_factor_receptor degradation .
16472692	0	Cdc42	72,77	epidermal_growth_factor_receptor	15,47	Cdc42	epidermal growth factor receptor	998	1956	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|turnover turnover|compound|END_ENTITY	Measurement of epidermal_growth_factor_receptor turnover and effects of Cdc42 .
16585176	0	Cdc42	137,142	epidermal_growth_factor_receptor	57,89	Cdc42	epidermal growth factor receptor	998	1956	Gene	Gene	inactivation|nmod|START_ENTITY correlated|nmod|inactivation correlated|nsubjpass|inhibition inhibition|nmod|cells cells|nmod|degradation degradation|compound|END_ENTITY	Growth and motility inhibition of breast_cancer cells by epidermal_growth_factor_receptor degradation is correlated with inactivation of Cdc42 .
18057010	0	Cdc42	0,5	epidermal_growth_factor_receptor	69,101	Cdc42	epidermal growth factor receptor	998	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal_growth_factor_receptor to Src-mediated pathway .
20473940	0	Cdc42	16,21	miR-137	0,7	Cdc42	miR-137	998	406928	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-137 targets Cdc42 expression , induces cell cycle G1 arrest and inhibits invasion in colorectal_cancer cells .
23178712	0	Cdc42	69,74	miR-137	0,7	Cdc42	miR-137	998	406928	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-137 inhibits the proliferation of lung_cancer cells by targeting Cdc42 and Cdk6 .
25781190	0	Cdc42	33,38	miR-30c	0,7	Cdc42	miR-30c	64465(Tax:10116)	407031	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	miR-30c mediates upregulation of Cdc42 and Pak1 in diabetic_cardiomyopathy .
23337504	0	Cdc42	76,81	miR-330	0,7	Cdc42	miR-330	998	442902	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR-330 regulates the proliferation of colorectal_cancer cells by targeting Cdc42 .
15247287	0	Cdc42	10,15	zizimin1	52,60	Cdc42	zizimin1	998	23348	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	The novel Cdc42 guanine_nucleotide exchange factor , zizimin1 , dimerizes via the Cdc42-binding CZH2 domain .
26287173	0	Cdc42-Interacting_Protein_4	0,27	E-Cadherin	38,48	Cdc42-Interacting Protein 4	E-Cadherin	106628(Tax:10090)	12550(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Cdc42-Interacting_Protein_4 Represses E-Cadherin Expression by Promoting b-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells .
22952966	0	Cdc42-associated_kinase_1	38,63	Cortactin	0,9	Cdc42-associated kinase 1	Cortactin	10188	2017	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Cortactin is a substrate of activated Cdc42-associated_kinase_1 -LRB- ACK1 -RRB- during ligand-induced epidermal_growth_factor_receptor downregulation .
18331715	0	Cdc42GAP	12,20	Nudel	0,5	Cdc42GAP	Nudel	392	81565	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells .
16157885	0	Cdc42GAP	0,8	c-Jun_N-terminal_kinase	19,42	Cdc42GAP	c-Jun N-terminal kinase	392	5599	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cdc42GAP regulates c-Jun_N-terminal_kinase -LRB- JNK -RRB- - mediated apoptosis and cell number during mammalian perinatal growth .
25109462	0	Cdc42Hs	54,61	PAK3	107,111	Cdc42Hs	PAK3	998	5063	Gene	Gene	START_ENTITY|nmod|Domain Domain|nmod|END_ENTITY	Dynamic and Thermodynamic Response of the Ras Protein Cdc42Hs upon Association with the Effector Domain of PAK3 .
27039663	0	Cdc42_interacting_protein_4	60,87	AKAP-9	0,6	Cdc42 interacting protein 4	AKAP-9	9322	10142	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	AKAP-9 promotes colorectal_cancer development by regulating Cdc42_interacting_protein_4 .
22918946	0	Cdc42p	0,6	Bni1p	38,43	Cdc42p	Bni1p	850930(Tax:4932)	855450(Tax:4932)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p .
22918946	0	Cdc42p	0,6	Gic2p	69,74	Cdc42p	Gic2p	850930(Tax:4932)	851904(Tax:4932)	Gene	Gene	regulation|amod|START_ENTITY mediated|nsubj|regulation mediated|nmod|END_ENTITY	Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p .
17887956	0	Cdc45	138,143	cell_division_cycle_45	114,136	Cdc45	cell division cycle 45	8318	8318	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Characterization of the interaction between the human DNA_topoisomerase_IIbeta-binding_protein_1 -LRB- TopBP1 -RRB- and the cell_division_cycle_45 -LRB- Cdc45 -RRB- protein .
20122406	0	Cdc45	54,59	helicase	25,33	Cdc45	helicase	31052(Tax:7227)	33118(Tax:7227)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins .
17083136	0	Cdc48	33,38	Dfm1	13,17	Cdc48	Dfm1	851431(Tax:4932)	852020(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis .
20016281	0	Cdc48	28,33	Int6	0,4	Cdc48	Int6	851431(Tax:4932)	3646	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation .
16179952	0	Cdc48	29,34	Ubx2	15,19	Cdc48	Ubx2	851431(Tax:4932)	854995(Tax:4932)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation .
8109176	0	Cdc48p	77,83	Pas1p	70,75	Cdc48p	Pas1p	851431(Tax:4932)	853636(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	Cdc48p	77,83	Sec18p	62,68	Cdc48p	Sec18p	851431(Tax:4932)	852372(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	Cdc48p	77,83	TBP-1	85,90	Cdc48p	TBP-1	851431(Tax:4932)	856891(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8890162	0	Cdc48p	0,6	Ufd3p	22,27	Cdc48p	Ufd3p	851431(Tax:4932)	853667(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cdc48p interacts with Ufd3p , a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces_cerevisiae .
8943317	0	Cdc4p	28,33	Cdc53p	0,6	Cdc4p	Cdc53p	55294	851424(Tax:4932)	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins .
11960554	0	Cdc5	0,4	Net1	35,39	Cdc5	Net1	988	10276	Gene	Gene	influences|nsubj|START_ENTITY influences|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex .
12056824	0	Cdc5	14,18	Net1	34,38	Cdc5	Net1	855013(Tax:4932)	853369(Tax:4932)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Budding yeast Cdc5 phosphorylates Net1 and assists Cdc14 release from the nucleolus .
9154840	0	Cdc5	56,60	Plk	0,3	Cdc5	Plk	855013(Tax:4932)	5347	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Plk is a functional homolog of Saccharomyces_cerevisiae Cdc5 , and elevated Plk activity induces multiple septation structures .
8943317	0	Cdc53p	0,6	Cdc4p	28,33	Cdc53p	Cdc4p	851424(Tax:4932)	55294	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins .
11536041	0	Cdc55	107,112	PP2A	137,141	Cdc55	PP2A	852685(Tax:4932)	5524	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Toxicity of human adenovirus E4orf4 protein in Saccharomyces_cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A .
19633697	0	Cdc5L	0,5	ATR	21,24	Cdc5L	ATR	988	545	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint .
9430660	0	Cdc6	25,29	Abf1	41,45	Cdc6	Abf1	853244(Tax:4932)	853748(Tax:4932)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Saccharomyces_cerevisiae Cdc6 stimulates Abf1 DNA binding activity .
15887248	0	Cdc6	28,32	Androgen_receptor	0,17	Cdc6	Androgen receptor	990	367	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Androgen_receptor regulates Cdc6 in synchronized LNCaP cells progressing from G1 to S phase .
18356301	0	Cdc6	60,64	Cdk2	52,56	Cdc6	Cdk2	990	1017	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6 .
11257126	0	Cdc6	14,18	Cyclin_E	0,8	Cdc6	Cyclin E	403388(Tax:8355)	397841(Tax:8355)	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Cyclin_E uses Cdc6 as a chromatin-associated receptor required for DNA replication .
11460169	0	Cdc6	0,4	Sic1	21,25	Cdc6	Sic1	853244(Tax:4932)	850768(Tax:4932)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases .
18541154	0	Cdc6	19,23	androgen_receptor	67,84	Cdc6	androgen receptor	990	367	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nmod|interactions interactions|nmod|factor factor|compound|END_ENTITY	Androgen regulates Cdc6 transcription through interactions between androgen_receptor and E2F transcription factor in prostate_cancer cells .
12151338	0	Cdc6	26,30	caspase_3	57,66	Cdc6	caspase 3	990	836	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Human replication protein Cdc6 is selectively cleaved by caspase_3 during apoptosis .
12065429	0	Cdc7	43,47	Drf1	0,4	Cdc7	Drf1	8317	80174	Gene	Gene	subunit|nmod|START_ENTITY kinase|nsubj|subunit kinase|advmod|END_ENTITY	Drf1 , a novel regulatory subunit for human Cdc7 kinase .
12897072	0	Cdc7	29,33	Drf1	8,12	Cdc7	Drf1	398099(Tax:8355)	398696(Tax:8355)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Xenopus Drf1 , a regulator of Cdc7 , displays checkpoint-dependent accumulation on chromatin during an S-phase arrest .
17046832	0	Cdc7	27,31	MCM4	19,23	Cdc7	MCM4	8317	4173	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin .
19864417	0	Cdc7-activator_of_S-phase_kinase	50,82	LEDGF	29,34	Cdc7-activator of S-phase kinase	LEDGF	10926	11168	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transcriptional co-activator LEDGF interacts with Cdc7-activator_of_S-phase_kinase -LRB- ASK -RRB- and stimulates its enzymatic activity .
18239684	0	Cdh1	89,93	CDK2	37,41	Cdh1	CDK2	999	1017	Gene	Gene	APC|appos|START_ENTITY protects|nmod|APC protects|nsubj|Phosphorylation Phosphorylation|nmod|Skp2 Skp2|acl|regulated regulated|nmod|END_ENTITY	Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC -LRB- Cdh1 -RRB- in G1 phase .
25485510	0	Cdh1	24,28	Cdk2	9,13	Cdh1	Cdk2	999	1017	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cyclin_A / Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle .
18818692	0	Cdh1	20,24	Cdk5	0,4	Cdh1	Cdk5	999	1020	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cdk5 phosphorylates Cdh1 and modulates cyclin_B1 stability in excitotoxicity .
22654103	0	Cdh1	54,58	Cdk5	0,4	Cdh1	Cdk5	999	1020	Gene	Gene	ubiquitination|amod|START_ENTITY triggers|nsubj|ubiquitination oscillate|parataxis|triggers oscillate|nsubj|levels levels|amod|END_ENTITY	Cdk5 levels oscillate during the neuronal cell cycle : Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase .
26963853	0	Cdh1	28,32	Cks1	45,49	Cdh1	Cks1	999	137529	Gene	Gene	binding|advmod|START_ENTITY binding|nmod|END_ENTITY	TGF-b activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth .
20395298	0	Cdh1	52,56	Damaged_DNA-binding_protein_1	0,29	Cdh1	Damaged DNA-binding protein 1	999	1642	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Damaged_DNA-binding_protein_1 -LRB- DDB1 -RRB- interacts with Cdh1 and modulates the function of APC/CCdh1 .
22580462	0	Cdh1	28,32	E2F1	14,18	Cdh1	E2F1	999	1869	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation .
15014502	0	Cdh1	60,64	SCF	15,18	Cdh1	SCF	999	4254	Gene	Gene	ubiquitin|appos|START_ENTITY ligase|nmod|ubiquitin ligase|compound|END_ENTITY	Control of the SCF -LRB- Skp2-Cks1 -RRB- ubiquitin ligase by the APC/C -LRB- Cdh1 -RRB- ubiquitin ligase .
15093536	0	Cdh1	54,58	SCF	74,77	Cdh1	SCF	999	4254	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Crashing waves of destruction : the cell cycle and APC -LRB- Cdh1 -RRB- regulation of SCF -LRB- Skp2 -RRB- .
12194827	0	Cdh1	93,97	fzr2	51,55	Cdh1	fzr2	45922(Tax:7227)	37808(Tax:7227)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Completion of mitosis requires neither fzr/rap nor fzr2 , a male germline-specific Drosophila Cdh1 homolog .
26420260	0	Cdh2	0,4	FGFR1	16,21	Cdh2	FGFR1	12558(Tax:10090)	14182(Tax:10090)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells .
22326520	0	Cdh23	64,69	age-related_hearing_loss	36,60	Cdh23	age-related hearing loss	22295(Tax:10090)	22295(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	A mutation in the cdh23 gene causes age-related_hearing_loss in Cdh23 -LRB- nmf308/nmf308 -RRB- mice .
8786117	0	Cdh5	73,77	VE-cadherin	55,66	Cdh5	VE-cadherin	12562(Tax:10090)	12562(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and chromosomal mapping of the mouse VE-cadherin gene -LRB- Cdh5 -RRB- .
25753036	0	Cdk1	0,4	Bora	27,31	Cdk1	Bora	176374(Tax:6239)	79866	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cdk1 phosphorylates SPAT-1 / Bora to trigger PLK-1 activation and drive mitotic entry in C. _ elegans embryos .
20876571	0	Cdk1	29,33	Cdc25B	49,55	Cdk1	Cdc25B	983	994	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	WITHDRAWN : Survivin mediates Cdk1 activation via Cdc25B early in mitosis .
17942597	0	Cdk1	13,17	Cdk2	36,40	Cdk1	Cdk2	12534(Tax:10090)	12566(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint .
21406398	0	Cdk1	15,19	Cep63	0,5	Cdk1	Cep63	983	80254	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Cep63 recruits Cdk1 to the centrosome : implications for regulation of mitotic entry , centrosome amplification , and genome maintenance .
25643699	0	Cdk1	15,19	Cep63	0,5	Cdk1	Cep63	983	80254	Gene	Gene	START_ENTITY|nsubj|Recruits Recruits|compound|END_ENTITY	Cep63 Recruits Cdk1 to the Centrosome-Letter .
16033797	0	Cdk1	33,37	Cks30A	11,17	Cdk1	Cks30A	34411(Tax:7227)	34250(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Drosophila Cks30A interacts with Cdk1 to target Cyclin_A for destruction in the female germline .
17408621	0	Cdk1	10,14	Cyclin_B1	0,9	Cdk1	Cyclin B1	983	891	Gene	Gene	binds|nsubj|START_ENTITY END_ENTITY|parataxis|binds	Cyclin_B1 / Cdk1 binds and phosphorylates Filamin_A and regulates its ability to cross-link actin .
24746669	0	Cdk1	10,14	Cyclin_B1	0,9	Cdk1	Cyclin B1	983	891	Gene	Gene	coordinates|nsubj|START_ENTITY END_ENTITY|parataxis|coordinates	Cyclin_B1 / Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression .
19591820	0	Cdk1	44,48	Cyclin_J	11,19	Cdk1	Cyclin J	34411(Tax:7227)	38428(Tax:7227)	Gene	Gene	partner|amod|START_ENTITY partner|nsubj|END_ENTITY	Drosophila Cyclin_J is a mitotically stable Cdk1 partner without essential functions .
18356527	0	Cdk1	23,27	FOXO1	14,19	Cdk1	FOXO1	983	2308	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons .
17408621	0	Cdk1	10,14	Filamin_A	40,49	Cdk1	Filamin A	983	2316	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Cyclin_B1 / Cdk1 binds and phosphorylates Filamin_A and regulates its ability to cross-link actin .
24551245	0	Cdk1	74,78	Filamin_B	0,9	Cdk1	Filamin B	983	2317	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Filamin_B regulates chondrocyte proliferation and differentiation through Cdk1 signaling .
22649246	0	Cdk1	93,97	Filamin_a	0,9	Cdk1	Filamin a	983	2316	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|nmod|phosphorylation regulates|nsubj|END_ENTITY	Filamin_a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation .
27068241	0	Cdk1	37,41	Fimbrin	0,7	Cdk1	Fimbrin	852457(Tax:4932)	851707(Tax:4932)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast .
26483157	0	Cdk1	74,78	LARG	65,69	Cdk1	LARG	983	23365	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Mitotic-dependent phosphorylation of leukemia-associated_RhoGEF -LRB- LARG -RRB- by Cdk1 .
19303298	0	Cdk1	0,4	Mklp2	70,75	Cdk1	Mklp2	983	10112	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex .
18347064	0	Cdk1	50,54	Protein_phosphatase_4_catalytic_subunit	0,39	Cdk1	Protein phosphatase 4 catalytic subunit	983	5531	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Protein_phosphatase_4_catalytic_subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation .
26177583	0	Cdk1	44,48	Sororin	33,40	Cdk1	Sororin	983	113130	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	Multiple Levels of Regulation of Sororin by Cdk1 and Aurora_B .
26078008	0	Cdk1	0,4	Tiam1	38,43	Cdk1	Tiam1	983	7074	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation .
12072468	0	Cdk1	37,41	Wee1	62,66	Cdk1	Wee1	34411(Tax:7227)	33965(Tax:7227)	Gene	Gene	kinases|amod|START_ENTITY kinases|appos|END_ENTITY	Ectopic expression of the Drosophila Cdk1 inhibitory kinases , Wee1 and Myt1 , interferes with the second mitotic wave and disrupts pattern formation during eye development .
15589158	0	Cdk1	33,37	Wee1	11,15	Cdk1	Wee1	34411(Tax:7227)	33965(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis .
15215233	0	Cdk1	96,100	cyclin_B1	86,95	Cdk1	cyclin B1	983	891	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Regulation of activation-induced Fas -LRB- CD95/Apo -1 -RRB- ligand expression in T cells by the cyclin_B1 / Cdk1 complex .
25107587	0	Cdk1	111,115	cyclin_B1	101,110	Cdk1	cyclin B1	983	891	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	MJ-66 induces malignant_glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin_B1 / Cdk1 complex .
25445790	0	Cdk1	32,36	filamin_A	47,56	Cdk1	filamin A	983	2316	Gene	Gene	filamin_A|nmod|START_ENTITY Phosphorylation|nmod|filamin_A regulates|nsubj|Phosphorylation regulates|dobj|localization localization|compound|END_ENTITY	Phosphorylation of filamin_A by Cdk1 regulates filamin_A localization and daughter cell separation .
26483157	0	Cdk1	74,78	leukemia-associated_RhoGEF	37,63	Cdk1	leukemia-associated RhoGEF	983	23365	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Mitotic-dependent phosphorylation of leukemia-associated_RhoGEF -LRB- LARG -RRB- by Cdk1 .
20808790	0	Cdk1	10,14	p53	48,51	Cdk1	p53	983	7157	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cyclin_B1 / Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response .
22797065	0	Cdk1	21,25	wee1	30,34	Cdk1	wee1	983	7465	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination .
22512864	0	Cdk12	19,24	Cyclin_K	0,8	Cdk12	Cyclin K	51755	8812	Gene	Gene	goes|nmod|START_ENTITY goes|nsubj|END_ENTITY	Cyclin_K goes with Cdk12 and Cdk13 .
26730572	0	Cdk2	0,4	BRMS1	37,42	Cdk2	BRMS1	1017	25855	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cdk2 regulates metastasis suppressor BRMS1 .
18356301	0	Cdk2	52,56	Cdc6	60,64	Cdk2	Cdc6	1017	990	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6 .
25485510	0	Cdk2	9,13	Cdh1	24,28	Cdk2	Cdh1	1017	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cyclin_A / Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle .
17942597	0	Cdk2	36,40	Cdk1	13,17	Cdk2	Cdk1	12566(Tax:10090)	12534(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint .
9178893	0	Cdk2	20,24	Cdk4	42,46	Cdk2	Cdk4	1017	1019	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	Cyclin_D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells .
17373709	0	Cdk2	15,19	Cdk7	23,27	Cdk2	Cdk7	1017	1022	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of Cdk2 by Cdk7 .
14767478	0	Cdk2	9,13	Cyclin_A	0,8	Cdk2	Cyclin A	1017	890	Gene	Gene	complexes|amod|START_ENTITY regulate|nsubj|complexes END_ENTITY|parataxis|regulate	Cyclin_A / Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells .
25485510	0	Cdk2	9,13	Cyclin_A	0,8	Cdk2	Cyclin A	1017	890	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Cyclin_A / Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle .
9178893	0	Cdk2	20,24	Cyclin_D2	0,9	Cdk2	Cyclin D2	1017	894	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Cyclin_D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells .
10234573	0	Cdk2	39,43	ERK	0,3	Cdk2	ERK	1017	5594	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells .
23168795	0	Cdk2	14,18	FAK	0,3	Cdk2	FAK	1017	5747	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	FAK regulates Cdk2 in EGF-stimulated primary cultures of hepatocytes .
19197163	0	Cdk2	6,10	Ime2	52,56	Cdk2	Ime2	1017	853338(Tax:4932)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Human Cdk2 is a functional homolog of budding yeast Ime2 , the meiosis-specific Cdk-like kinase .
21099355	0	Cdk2	28,32	Ime2	56,60	Cdk2	Ime2	1017	853338(Tax:4932)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Ectopic expression of human Cdk2 and its yeast homolog , Ime2 , is deleterious to Saccharomyces_cerevisiae .
16343435	0	Cdk2	51,55	PKCdelta	0,8	Cdk2	PKCdelta	1017	5580	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis .
18838553	0	Cdk2	0,4	SMRT	66,70	Cdk2	SMRT	1017	9612	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT .
24269842	0	Cdk2	57,61	Skp2	34,38	Cdk2	Skp2	12566(Tax:10090)	27401(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	p27 is regulated independently of Skp2 in the absence of Cdk2 .
10095772	0	Cdk2	27,31	cyclin_A	18,26	Cdk2	cyclin A	1017	890	Gene	Gene	sites|amod|START_ENTITY Identification|dep|sites Identification|nmod|END_ENTITY	Identification of cyclin_A / Cdk2 phosphorylation sites in B-Myb .
11423988	0	Cdk2	23,27	cyclin_A	14,22	Cdk2	cyclin A	1017	890	Gene	Gene	impairs|amod|START_ENTITY B-Myb|nsubj|impairs Inhibition|parataxis|B-Myb Inhibition|nmod|END_ENTITY	Inhibition of cyclin_A / Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator .
15601848	0	Cdk2	105,109	cyclin_A	96,104	Cdk2	cyclin A	1017	890	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Cyclin-dependent kinase activity is required for progesterone_receptor function : novel role for cyclin_A / Cdk2 as a progesterone_receptor coactivator .
15707957	0	Cdk2	44,48	cyclin_A	59,67	Cdk2	cyclin A	1017	890	Gene	Gene	moiety|amod|START_ENTITY moiety|nmod|Cdk2 Cdk2|amod|END_ENTITY	Functional interaction of Puralpha with the Cdk2 moiety of cyclin_A / Cdk2 .
16081423	0	Cdk2	52,56	cyclin_A	43,51	Cdk2	cyclin A	1017	890	Gene	Gene	regulation|parataxis|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of CDP/Cux p110 by cyclin_A / Cdk2 and cyclin_A / Cdk1 .
19858290	0	Cdk2	74,78	cyclin_A	65,73	Cdk2	cyclin A	1017	890	Gene	Gene	element|dep|START_ENTITY element|nmod|END_ENTITY	A bifunctional regulatory element in human somatic Wee1 mediates cyclin_A / Cdk2 binding and Crm1-dependent nuclear export .
9294175	0	Cdk2	76,80	cyclin_A	67,75	Cdk2	cyclin A	1017	890	Gene	Gene	complex|nmod:npmod|START_ENTITY END_ENTITY|amod|complex	Regulation of estrogen_receptor transcriptional enhancement by the cyclin_A / Cdk2 complex .
23627734	0	Cdk2	61,65	cyclin_D1	51,60	Cdk2	cyclin D1	1017	595	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Assembly , activation , and substrate specificity of cyclin_D1 / Cdk2 complexes .
10790398	0	Cdk2	164,168	cyclin_E	26,34	Cdk2	cyclin E	42453(Tax:7227)	34924(Tax:7227)	Gene	Gene	revealing|nmod|START_ENTITY identifies|advcl|revealing identifies|nsubj|screen screen|nmod|modifiers modifiers|nmod|function function|amod|END_ENTITY	A screen for modifiers of cyclin_E function in Drosophila_melanogaster identifies Cdk2 mutations , revealing the insignificance of putative phosphorylation sites in Cdk2 .
10790398	0	Cdk2	82,86	cyclin_E	26,34	Cdk2	cyclin E	42453(Tax:7227)	34924(Tax:7227)	Gene	Gene	mutations|amod|START_ENTITY identifies|dobj|mutations identifies|nsubj|screen screen|nmod|modifiers modifiers|nmod|function function|amod|END_ENTITY	A screen for modifiers of cyclin_E function in Drosophila_melanogaster identifies Cdk2 mutations , revealing the insignificance of putative phosphorylation sites in Cdk2 .
12149264	0	Cdk2	54,58	cyclin_E	26,34	Cdk2	cyclin E	362817(Tax:10116)	25729(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY confined|nmod|activation confined|nsubjpass|activity activity|nmod|END_ENTITY	The oncogenic activity of cyclin_E is not confined to Cdk2 activation alone but relies on several other , distinct functions of the protein .
12914904	0	Cdk2	32,36	cyclin_E	23,31	Cdk2	cyclin E	399314(Tax:8355)	397841(Tax:8355)	Gene	Gene	timer|amod|START_ENTITY model|dep|timer model|nmod|END_ENTITY	A kinetic model of the cyclin_E / Cdk2 developmental timer in Xenopus_laevis embryos .
18414041	0	Cdk2	120,124	cyclin_E	111,119	Cdk2	cyclin E	399314(Tax:8355)	397841(Tax:8355)	Gene	Gene	timer|amod|START_ENTITY timer|amod|END_ENTITY	Chk1 is activated at the midblastula_transition in Xenopus_laevis embryos independently of DNA content and the cyclin_E / Cdk2 developmental timer .
9268577	0	Cdk2	20,24	cyclin_E	11,19	Cdk2	cyclin E	399314(Tax:8355)	397841(Tax:8355)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for cyclin_E / Cdk2 in the timing of the midblastula_transition in Xenopus embryos .
17371838	0	Cdk2	35,39	p21	52,55	Cdk2	p21	1017	644914	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Mdm2 is required for inhibition of Cdk2 activity by p21 , thereby contributing to p53-dependent cell cycle arrest .
17942597	0	Cdk2	36,40	p21	0,3	Cdk2	p21	12566(Tax:10090)	12575(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY Cdk1|nmod|absence Cdk1|nsubj|Inhibits Inhibits|amod|END_ENTITY	p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint .
21325496	0	Cdk2	60,64	p21	34,37	Cdk2	p21	1017	1026	Gene	Gene	role|nmod|START_ENTITY regulates|dobj|role regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity .
17434927	0	Cdk2	131,135	p27Kip1	8,15	Cdk2	p27Kip1	12566(Tax:10090)	12576(Tax:10090)	Gene	Gene	ranging|nmod|START_ENTITY tumorigenesis|acl|ranging enhances|nmod|tumorigenesis enhances|nsubj|Loss Loss|nmod|END_ENTITY	Loss of p27Kip1 enhances tumor progression in chronic hepatocyte injury-induced liver tumorigenesis with widely ranging effects on Cdk2 or Cdc2 activation .
14701845	0	Cdk4	90,94	Cdc37	59,64	Cdk4	Cdc37	1019	11140	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Identification of a conserved sequence motif that promotes Cdc37 and cyclin_D1 binding to Cdk4 .
9178893	0	Cdk4	42,46	Cdk2	20,24	Cdk4	Cdk2	1019	1017	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	Cyclin_D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells .
23333330	0	Cdk4	10,14	Cyclin_D1	0,9	Cdk4	Cyclin D1	1019	595	Gene	Gene	increases|nsubj|START_ENTITY END_ENTITY|parataxis|increases	Cyclin_D1 / Cdk4 increases the transcriptional activity of FOXM1c without phosphorylating FOXM1c .
8058330	0	Cdk4	110,114	Cyclin_D1	131,140	Cdk4	Cyclin D1	1019	595	Gene	Gene	association|nmod|START_ENTITY protein|dep|association expression|nmod|protein required|nsubjpass|expression required|nmod|function function|amod|END_ENTITY	Differential expression and regulation of Cyclin_D1 protein in normal and tumor human cells : association with Cdk4 is required for Cyclin_D1 function in G1 progression .
8058330	0	Cdk4	110,114	Cyclin_D1	42,51	Cdk4	Cyclin D1	1019	595	Gene	Gene	association|nmod|START_ENTITY protein|dep|association protein|amod|END_ENTITY	Differential expression and regulation of Cyclin_D1 protein in normal and tumor human cells : association with Cdk4 is required for Cyclin_D1 function in G1 progression .
9190208	0	Cdk4	10,14	Cyclin_D1	0,9	Cdk4	Cyclin D1	1019	595	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Cyclin_D1 / Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation .
9178893	0	Cdk4	42,46	Cyclin_D2	0,9	Cdk4	Cyclin D2	1019	894	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Cyclin_D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells .
14960278	0	Cdk4	20,24	Hif-1_prolyl_hydroxylase	34,58	Cdk4	Hif-1 prolyl hydroxylase	36854(Tax:7227)	40633(Tax:7227)	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	Drosophila cyclin_D / Cdk4 requires Hif-1_prolyl_hydroxylase to drive cell growth .
8666233	0	Cdk4	92,96	Hsp90	60,65	Cdk4	Hsp90	1019	3320	Gene	Gene	binds|dobj|START_ENTITY END_ENTITY|acl:relcl|binds	Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4 .
11466616	0	Cdk4	54,58	P21	0,3	Cdk4	P21	12567(Tax:10090)	12575(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY associated|nmod|activity associated|nsubjpass|END_ENTITY	P21 -LRB- Cip1 -RRB- induced by Raf is associated with increased Cdk4 activity in hematopoietic cells .
11880344	0	Cdk4	96,100	RBF	12,15	Cdk4	RBF	36854(Tax:7227)	43231(Tax:7227)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin_D / Cdk4 induced cellular growth .
21084836	0	Cdk4	40,44	STAT1	0,5	Cdk4	STAT1	1019	6772	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	STAT1 interacts directly with cyclin_D1 / Cdk4 and mediates cell cycle arrest .
10973815	0	Cdk4	41,45	cyclin-dependent_kinase_4	14,39	Cdk4	cyclin-dependent kinase 4	1019	1019	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- by fascaplysin , a marine natural product .
19954867	0	Cdk4	81,85	cyclin-dependent_kinase_4	54,79	Cdk4	cyclin-dependent kinase 4	1019	1019	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Radiosynthesis and radiopharmacological evaluation of cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- inhibitors .
9837900	0	Cdk4	55,59	cyclin-dependent_kinase_4	28,53	Cdk4	cyclin-dependent kinase 4	94201(Tax:10116)	94201(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Calmodulin is essential for cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- activity and nuclear accumulation of cyclin_D1-Cdk4 during G1 .
11481417	0	Cdk4	32,36	cyclin_D1	22,31	Cdk4	cyclin D1	1019	595	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Downregulation of the cyclin_D1 / Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon_cancer cell lines .
14522882	0	Cdk4	30,34	cyclin_D1	20,29	Cdk4	cyclin D1	94201(Tax:10116)	58919(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Deregulation of the cyclin_D1 / Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo -LSB- 4,5-b -RSB- pyridine .
14710852	0	Cdk4	39,43	cyclin_D1	19,28	Cdk4	cyclin D1	1019	595	Gene	Gene	synthesis|amod|START_ENTITY regulates|dobj|synthesis regulates|nsubj|Over-expression Over-expression|nmod|END_ENTITY	Over-expression of cyclin_D1 regulates Cdk4 protein synthesis .
14754892	0	Cdk4	24,28	cyclin_D1	14,23	Cdk4	cyclin D1	1019	595	Gene	Gene	complexes|amod|START_ENTITY kinase|nsubj|complexes Regulation|parataxis|kinase Regulation|nmod|END_ENTITY	Regulation of cyclin_D1 / Cdk4 complexes by calcium/calmodulin-dependent protein kinase I .
16582602	0	Cdk4	20,24	cyclin_D1	10,19	Cdk4	cyclin D1	36854(Tax:7227)	595	Gene	Gene	complexes|amod|START_ENTITY induce|nsubj|complexes END_ENTITY|parataxis|induce	Mammalian cyclin_D1 / Cdk4 complexes induce cell growth in Drosophila .
8988060	0	Cdk4	70,74	cyclin_D1	29,38	Cdk4	cyclin D1	12567(Tax:10090)	12443(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Concurrent overexpression of cyclin_D1 and cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- in intestinal adenomas from multiple_intestinal_neoplasia -LRB- Min -RRB- mice and human familial_adenomatous_polyposis patients .
9099745	0	Cdk4	31,35	cyclin_D1	103,112	Cdk4	cyclin D1	1019	595	Gene	Gene	activation|nmod|START_ENTITY accompanied|nsubjpass|activation accompanied|nmod|expression expression|amod|END_ENTITY	Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin_D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2 .
16410729	0	Cdk4	73,77	cyclin_D2	63,72	Cdk4	cyclin D2	1019	894	Gene	Gene	dependent|dep|START_ENTITY END_ENTITY|parataxis|dependent	Beta-cell growth : an unusual paradigm of organogenesis that is cyclin_D2 / Cdk4 dependent .
10585273	0	Cdk4	53,57	p16	103,106	Cdk4	p16	1019	1029	Gene	Gene	activation|nmod|START_ENTITY underlying|dobj|activation mechanisms|acl|underlying mechanisms|dep|roles roles|nmod|END_ENTITY	Complex mechanisms underlying impaired activation of Cdk4 and Cdk2 in replicative senescence : roles of p16 , p21 , and cyclin_D1 .
19352455	0	Cdk4	91,95	p16	34,37	Cdk4	p16	1019	1029	Gene	Gene	truncated|nmod|START_ENTITY truncated|dobj|forms forms|amod|END_ENTITY	Simulation of different truncated p16 -LRB- INK4a -RRB- forms and in silico study of interaction with Cdk4 .
7566978	0	Cdk4	70,74	p16	0,3	Cdk4	p16	1019	1029	Gene	Gene	deficient|nmod|START_ENTITY deficient|nsubj|proteins proteins|amod|END_ENTITY	p16 proteins from melanoma-prone families are deficient in binding to Cdk4 .
10713676	0	Cdk4	86,90	p21	32,35	Cdk4	p21	1019	644914	Gene	Gene	initiates|nmod|START_ENTITY initiates|dep|formation formation|amod|END_ENTITY	Survivin initiates procaspase_3 / p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death .
11790141	0	Cdk4	69,73	p21	22,25	Cdk4	p21	1019	1026	Gene	Gene	bound|nmod|START_ENTITY domain|acl|bound C-terminal|dobj|domain C-terminal|nsubj|structure structure|nmod|END_ENTITY	Solution structure of p21 -LRB- Waf1/Cip1/Sdi1 -RRB- C-terminal domain bound to Cdk4 .
15735718	0	Cdk4	59,63	p21	13,16	Cdk4	p21	1019	644914	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|Induction Induction|nmod|END_ENTITY	Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities .
18818692	0	Cdk5	0,4	Cdh1	20,24	Cdk5	Cdh1	1020	999	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cdk5 phosphorylates Cdh1 and modulates cyclin_B1 stability in excitotoxicity .
22654103	0	Cdk5	0,4	Cdh1	54,58	Cdk5	Cdh1	1020	999	Gene	Gene	levels|amod|START_ENTITY oscillate|nsubj|levels oscillate|parataxis|triggers triggers|nsubj|ubiquitination ubiquitination|amod|END_ENTITY	Cdk5 levels oscillate during the neuronal cell cycle : Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase .
15066157	0	Cdk5	127,131	DARPP-32	150,158	Cdk5	DARPP-32	140908(Tax:10116)	360616(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Repeated acetyl-l-carnitine administration increases phospho-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phospho-Thr75 DARPP-32 levels in rat striatum .
24917152	0	Cdk5	0,4	EFhd2	24,29	Cdk5	EFhd2	12568(Tax:10090)	27984(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity .
24142862	0	Cdk5	0,4	ErbB4	24,29	Cdk5	ErbB4	1020	2066	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons .
14712065	0	Cdk5	0,4	FAK	24,27	Cdk5	FAK	1020	5747	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration .
25785643	0	Cdk5	0,4	IL-2	14,18	Cdk5	IL-2	12568(Tax:10090)	16183(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex .
18628310	0	Cdk5	25,29	Kalirin	14,21	Cdk5	Kalirin	140908(Tax:10116)	84009(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Kalirin by Cdk5 .
11163260	0	Cdk5	17,21	LIS1	53,57	Cdk5	LIS1	1020	5048	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein .
26930193	0	Cdk5	48,52	LRRK2	18,23	Cdk5	LRRK2	1020	120892	Gene	Gene	Phosphorylation|compound|START_ENTITY Enables|dobj|Phosphorylation Enables|nsubj|R1628P R1628P|compound|END_ENTITY	Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity .
26930193	0	Cdk5	48,52	LRRK2	72,77	Cdk5	LRRK2	1020	120892	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity .
8662984	0	Cdk5	77,81	NF-H	68,72	Cdk5	NF-H	140908(Tax:10116)	24587(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of the high molecular weight neurofilament protein -LRB- NF-H -RRB- by Cdk5 and p35 .
18184784	0	Cdk5	0,4	NR2B	52,56	Cdk5	NR2B	1020	2904	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|nmod|receptors receptors|amod|tyrosine tyrosine|dep|END_ENTITY	Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors .
24607229	0	Cdk5	32,36	NR2B	51,55	Cdk5	NR2B	1020	2904	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Memory enhancement by targeting Cdk5 regulation of NR2B .
21346193	0	Cdk5	25,29	Nestin	0,6	Cdk5	Nestin	1020	10763	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Nestin as a regulator of Cdk5 in differentiating myoblasts .
18625302	0	Cdk5	0,4	PLD2	20,24	Cdk5	PLD2	140908(Tax:10116)	25097(Tax:10116)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cdk5 phosphorylates PLD2 to mediate EGF-dependent insulin secretion .
23416045	0	Cdk5	0,4	Rap1	15,19	Cdk5	Rap1	1020	27342	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Cdk5 regulates Rap1 activity .
17145757	0	Cdk5	0,4	STAT3	15,20	Cdk5	STAT3	1020	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Cdk5 regulates STAT3 activation and cell proliferation in medullary_thyroid_carcinoma cells .
15280426	0	Cdk5	0,4	Src	46,49	Cdk5	Src	12568(Tax:10090)	20779(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Cdk5 regulates activation and localization of Src during corneal epithelial wound closure .
21442427	0	Cdk5	0,4	Src	20,23	Cdk5	Src	1020	6714	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src -LRB- S75 -RRB- .
23064382	0	Cdk5	24,28	TrkB	0,4	Cdk5	TrkB	12568(Tax:10090)	18212(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory .
18701695	0	Cdk5	0,4	WAVE2	24,29	Cdk5	WAVE2	1020	10163	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn .
15816873	0	Cdk5	38,42	cyclin-dependent_kinase_5	11,36	Cdk5	cyclin-dependent kinase 5	12568(Tax:10090)	12568(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Control of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity by glutamatergic regulation of p35 stability .
16962740	0	Cdk5	69,73	cyclin-dependent_kinase_5	42,67	Cdk5	cyclin-dependent kinase 5	140908(Tax:10116)	140908(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Prenatal cocaine and morphine alter brain cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity in rat pups .
10100871	0	Cdk5	31,35	dbpA	20,24	Cdk5	dbpA	1020	8531	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	DNA_binding_protein dbpA binds Cdk5 and inhibits its activity .
15911879	0	Cdk5	0,4	huntingtin	24,34	Cdk5	huntingtin	12568(Tax:10090)	15194(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases : implications for mutant huntingtin toxicity .
15911879	0	Cdk5	0,4	huntingtin	93,103	Cdk5	huntingtin	12568(Tax:10090)	15194(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY reduces|nsubj|phosphorylation reduces|parataxis|implications implications|nmod|toxicity toxicity|compound|END_ENTITY	Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases : implications for mutant huntingtin toxicity .
10604467	0	Cdk5	37,41	p25	21,24	Cdk5	p25	1020	8851	Gene	Gene	activity|amod|START_ENTITY deregulates|dobj|activity deregulates|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration .
14642273	0	Cdk5	9,13	p25	28,31	Cdk5	p25	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary_tangles .
21338355	0	Cdk5	84,88	p25	106,109	Cdk5	p25	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	p35|amod|START_ENTITY cleavage|nmod|p35 regulates|dobj|cleavage regulates|nmod|END_ENTITY	Calpastatin , an endogenous calpain-inhibitor protein , regulates the cleavage of the Cdk5 activator p35 to p25 .
8622924	0	Cdk5	40,44	p27Kip1	69,76	Cdk5	p27Kip1	12568(Tax:10090)	12576(Tax:10090)	Gene	Gene	allows|dobj|START_ENTITY allows|xcomp|escape escape|nmod|END_ENTITY	The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons .
16341208	0	Cdk5	0,4	p27kip1	35,42	Cdk5	p27kip1	12568(Tax:10090)	12576(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration .
10604467	0	Cdk5	37,41	p35	14,17	Cdk5	p35	1020	8851	Gene	Gene	activity|amod|START_ENTITY deregulates|dobj|activity deregulates|nsubj|Conversion Conversion|nmod|p25 p25|nummod|END_ENTITY	Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration .
11331872	0	Cdk5	48,52	p35	12,15	Cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	ERK induces p35 , a neuron-specific activator of Cdk5 , through induction of Egr1 .
12123804	0	Cdk5	12,16	p35	27,30	Cdk5	p35	1020	8851	Gene	Gene	survey|nmod|START_ENTITY activator|nsubj|survey activator|dobj|levels levels|amod|END_ENTITY	A survey of Cdk5 activator p35 and p25 levels in Alzheimer 's _ disease brains .
12230554	0	Cdk5	85,89	p35	58,61	Cdk5	p35	1020	8851	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|peptide peptide|appos|END_ENTITY	A peptide derived from cyclin-dependent kinase activator -LRB- p35 -RRB- specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells .
14521924	0	Cdk5	42,46	p35	57,60	Cdk5	p35	1020	8851	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein .
15816873	0	Cdk5	38,42	p35	84,87	Cdk5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY Control|nmod|activity Control|nmod|stability stability|amod|END_ENTITY	Control of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity by glutamatergic regulation of p35 stability .
15992363	0	Cdk5	48,52	p35	54,57	Cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	cyclin-dependent_kinase_5|appos|START_ENTITY Activation|nmod|cyclin-dependent_kinase_5 Activation|dep|complexes complexes|amod|END_ENTITY	Activation of latent cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- - p35 complexes by membrane dissociation .
17295212	0	Cdk5	23,27	p35	44,47	Cdk5	p35	1020	8851	Gene	Gene	presence|nmod|START_ENTITY associated|nsubj|presence associated|nmod|END_ENTITY	The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte .
17491008	0	Cdk5	57,61	p35	40,43	Cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY association|nmod|activator activator|amod|END_ENTITY	Microtubule association of the neuronal p35 activator of Cdk5 .
17526058	0	Cdk5	87,91	p35	37,40	Cdk5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY inhibit|dobj|activity inhibit|nsubj|Peptides Peptides|acl|derived derived|nmod|END_ENTITY	Peptides derived from Cdk5 activator p35 , specifically inhibit deregulated activity of Cdk5 .
20081373	0	Cdk5	87,91	p35	56,59	Cdk5	p35	1020	8851	Gene	Gene	microcephaly|appos|START_ENTITY microcephaly|appos|END_ENTITY	The primary microcephaly 3 -LRB- MCPH3 -RRB- interacting protein , p35 and its catalytic subunit , Cdk5 , are centrosomal proteins .
20130526	0	Cdk5	33,37	p35	0,3	Cdk5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	p35 , the non-cyclin activator of Cdk5 , protects podocytes against apoptosis in vitro and in vivo .
20720012	0	Cdk5	49,53	p35	40,43	Cdk5	p35	1020	8851	Gene	Gene	activator|amod|START_ENTITY END_ENTITY|appos|activator	A 24-residue peptide -LRB- p5 -RRB- , derived from p35 , the Cdk5 neuronal activator , specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation .
20976519	0	Cdk5	30,34	p35	13,16	Cdk5	p35	1020	8851	Gene	Gene	activator|nmod|START_ENTITY activator|amod|END_ENTITY	The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein .
21736731	0	Cdk5	21,25	p35	57,60	Cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Resveratrol inhibits Cdk5 activity through regulation of p35 expression .
23038754	0	Cdk5	32,36	p35	25,28	Cdk5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activator|amod|START_ENTITY END_ENTITY|appos|activator	A truncated peptide from p35 , a Cdk5 activator , prevents Alzheimer 's _ disease phenotypes in model mice .
24085300	0	Cdk5	70,74	p35	90,93	Cdk5	p35	1020	8851	Gene	Gene	complexes|amod|START_ENTITY stability|nmod|complexes basis|nmod|stability basis|nmod|activators activators|amod|END_ENTITY	Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators .
24326517	0	Cdk5	36,40	p35	29,32	Cdk5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activator|amod|START_ENTITY END_ENTITY|appos|activator	TFP5 , a peptide derived from p35 , a Cdk5 neuronal activator , rescues cortical neurons from glucose toxicity .
24755075	0	Cdk5	28,32	p35	71,74	Cdk5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|transcription transcription|nmod|mRNA mRNA|amod|END_ENTITY	Valproic_acid downregulates Cdk5 activity via the transcription of the p35 mRNA .
26631721	0	Cdk5	36,40	p35	32,35	Cdk5	p35	1020	8851	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Two degradation pathways of the p35 Cdk5 activation subunit , dependent and independent of ubiquitination .
26961960	0	Cdk5	149,153	p35	116,119	Cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Cyclic_AMP and Polyamines Overcome Inhibition by Myelin-Associated_Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5 .
8622924	0	Cdk5	40,44	p35	29,32	Cdk5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	allows|dobj|START_ENTITY allows|nsubj|END_ENTITY	The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons .
9727024	0	Cdk5	67,71	p35	0,3	Cdk5	p35	1020	8851	Gene	Gene	cyclin-dependent_kinase_5|appos|START_ENTITY activator|nmod|cyclin-dependent_kinase_5 END_ENTITY|appos|activator	p35 , the neuronal-specific activator of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- is degraded by the ubiquitin-proteasome pathway .
23645679	0	Cdk5	58,62	p39	0,3	Cdk5	p39	12568(Tax:10090)	12570(Tax:10090)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	p39 , the primary activator for cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- in oligodendroglia , is essential for oligodendroglia differentiation and myelin repair .
12064478	0	Cdk5	0,4	p53	20,23	Cdk5	p53	140908(Tax:10116)	301300(Tax:10116)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cdk5 phosphorylates p53 and regulates its activity .
16021178	0	Cdk5	51,55	p53	0,3	Cdk5	p53	1020	7157	Gene	Gene	activation|amod|START_ENTITY dispensable|nmod|activation dispensable|nsubj|END_ENTITY	p53 , Apaf-1 , caspase-3 , _ and _ -9 are dispensable for Cdk5 activation during cell death .
17591690	0	Cdk5	47,51	p53	32,35	Cdk5	p53	1020	7157	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death .
20673369	0	Cdk5	0,4	p53	52,55	Cdk5	p53	1020	7157	Gene	Gene	phosphorylates|amod|START_ENTITY overexpressed|nsubj|phosphorylates overexpressed|dobj|inhibition inhibition|compound|END_ENTITY	Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression .
11278334	0	Cdk5	54,58	protein_phosphatase_inhibitor-1	19,50	Cdk5	protein phosphatase inhibitor-1	1020	5502	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of protein_phosphatase_inhibitor-1 by Cdk5 .
15447670	0	Cdk5	72,76	tyrosine_hydroxylase	18,38	Cdk5	tyrosine hydroxylase	140908(Tax:10116)	25085(Tax:10116)	Gene	Gene	substrate|nmod|START_ENTITY Identification|nmod|substrate Identification|nmod|END_ENTITY	Identification of tyrosine_hydroxylase as a physiological substrate for Cdk5 .
20471352	0	Cdk5rap2	0,8	pericentrin	24,35	Cdk5rap2	pericentrin	55755	5116	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex .
9332304	0	Cdk6	147,151	Granulocyte-macrophage_colony-stimulating_factor	0,48	Cdk6	Granulocyte-macrophage colony-stimulating factor	1021	1437	Gene	Gene	abrogates|nmod|START_ENTITY abrogates|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor abrogates transforming_growth_factor-beta_1-mediated cell cycle arrest by up-regulating cyclin_D2 / Cdk6 .
9751050	0	Cdk6	63,67	p16INK4a	93,101	Cdk6	p16INK4a	1021	1029	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a .
17373709	0	Cdk7	23,27	Cdk2	15,19	Cdk7	Cdk2	1022	1017	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of Cdk2 by Cdk7 .
11319144	0	Cdk7	35,39	cyclin_H	26,34	Cdk7	cyclin H	12572(Tax:10090)	66671(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Meiotic expression of the cyclin_H / Cdk7 complex in male germ cells of the mouse .
8730095	0	Cdk8	11,15	cyclin_C	37,45	Cdk8	cyclin C	856065(Tax:4932)	892	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Drosophila Cdk8 , a kinase partner of cyclin_C that interacts with the large subunit of RNA polymerase II .
12386808	0	Cdk9	0,4	gp130	60,65	Cdk9	gp130	1025	3572	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Cdk9 , a member of the cdc2-like family of kinases , binds to gp130 , the receptor of the IL-6 family of cytokines .
16741955	0	Cdk9	0,4	p53	20,23	Cdk9	p53	1025	7157	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cdk9 phosphorylates p53 on serine 392 independently of CKII .
17942552	0	Cdk9	64,68	p53	117,120	Cdk9	p53	1025	7157	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|suppressor suppressor|compound|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor .
26861296	0	Cdkn1A-Interacting_Zinc_Finger_Protein_1	12,52	CIZ1	54,58	Cdkn1A-Interacting Zinc Finger Protein 1	CIZ1	25792;1026	25792	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Cdkn1A-Interacting_Zinc_Finger_Protein_1 -LRB- CIZ1 -RRB- in DNA Replication and Pathophysiology .
24497168	0	Cdkn1a	91,97	Ring1B	0,6	Cdkn1a	Ring1B	12575(Tax:10090)	19821(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice .
25979571	0	Cdkn1c	73,79	angiotensin_II	91,105	Cdkn1c	angiotensin II	246060(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Losartan reverses the down-expression of long noncoding RNA-NR024118 and Cdkn1c induced by angiotensin_II in adult rat cardiac fibroblasts .
26988311	0	Cdkn1c	61,67	kip2	54,58	Cdkn1c	kip2	12577(Tax:10090)	12577(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	The developmental expression of the CDK inhibitor p57 -LRB- kip2 -RRB- -LRB- Cdkn1c -RRB- in the early mouse placenta .
26988311	0	Cdkn1c	61,67	p57	50,53	Cdkn1c	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The developmental expression of the CDK inhibitor p57 -LRB- kip2 -RRB- -LRB- Cdkn1c -RRB- in the early mouse placenta .
26728554	0	Cdkn2a	86,92	Hhex	32,36	Cdkn2a	Hhex	1029	3087	Gene	Gene	repression|nmod|START_ENTITY enable|dobj|repression requires|xcomp|enable requires|dobj|END_ENTITY	Acute myeloid_leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a .
20484574	0	Cdo	0,3	APPL1	19,24	Cdo	APPL1	1036	26060	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cdo interacts with APPL1 and activates Akt in myoblast differentiation .
19470755	0	Cdo	0,3	Abl	10,13	Cdo	Abl	50937	25	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Cdo binds Abl to promote p38alpha/beta mitogen-activated protein kinase activity and myogenic differentiation .
21820049	0	Cdo	21,24	Gas1	0,4	Cdo	Gas1	57810(Tax:10090)	14451(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Gas1 cooperates with Cdo and promotes myogenic differentiation via activation of p38MAPK .
25406935	0	Cdo	0,3	Lrp6	61,65	Cdo	Lrp6	1036	4040	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation .
22337877	0	Cdo	119,122	TGF-b-activated_kinase_1	0,24	Cdo	TGF-b-activated kinase 1	12583(Tax:10090)	26409(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	TGF-b-activated_kinase_1 -LRB- TAK1 -RRB- and apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway .
10531348	0	Cds1	14,18	Chk2	20,24	Cds1	Chk2	1040	11200	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of human Cds1 -LRB- Chk2 -RRB- kinase in DNA damage checkpoint and its regulation by p53 .
15509799	0	Cds1	8,12	DNA-dependent_protein_kinase	29,57	Cds1	DNA-dependent protein kinase	398179(Tax:8355)	373602(Tax:8355)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Xenopus Cds1 is regulated by DNA-dependent_protein_kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends .
24280901	0	Cdt1	14,18	ATM	0,3	Cdt1	ATM	81620	472	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication .
19656945	0	Cdt1	19,23	Geminin	0,7	Cdt1	Geminin	398024(Tax:8355)	399373(Tax:8355)	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes .
21856198	0	Cdt1	24,28	JNK1	0,4	Cdt1	JNK1	81620	5599	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress .
18657502	0	Cdt1	11,15	MCM9	0,4	Cdt1	MCM9	81620	254394	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MCM9 binds Cdt1 and is required for the assembly of prereplication complexes .
20623209	0	Cdt1	50,54	Mcm6	79,83	Cdt1	Mcm6	81620	4175	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	1H , _ 15N_and_13C chemical shift assignments of the Cdt1 binding domain of human Mcm6 .
25483089	0	Cdt1	92,96	cyclin_A	98,106	Cdt1	cyclin A	81620	890	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of the p12 subunit of human DNA polymerase -LRB- Pol -RRB- , CDK inhibitor p21 -LRB- WAF1 -RRB- , Cdt1 , cyclin_A , PCNA and Ki-67 in relation to DNA replication in individual cells .
25483089	0	Cdt1	92,96	p21	81,84	Cdt1	p21	81620	1026	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|CDK CDK|dep|END_ENTITY	Expression of the p12 subunit of human DNA polymerase -LRB- Pol -RRB- , CDK inhibitor p21 -LRB- WAF1 -RRB- , Cdt1 , cyclin_A , PCNA and Ki-67 in relation to DNA replication in individual cells .
23029527	0	Cdt2	37,41	ATR	18,21	Cdt2	ATR	51514	545	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Checkpoint kinase ATR phosphorylates Cdt2 , a substrate receptor of CRL4 ubiquitin ligase , and promotes the degradation of Cdt1 following UV irradiation .
22015720	0	Cdx	0,3	Dll1	14,18	Cdx	Dll1	12590(Tax:10090)	13388(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cdx regulates Dll1 in multiple lineages .
12360479	0	Cdx-2	57,62	TNF-alpha	9,18	Cdx-2	TNF-alpha	12591(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K , PKB/Akt , and NF-kappaB-dependent pathway .
23649760	0	Cdx-2	4,9	VDR	30,33	Cdx-2	VDR	1045	7421	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	The Cdx-2 polymorphism in the VDR gene is associated with increased risk of cancer : a meta-analysis .
11450701	0	Cdx-2	59,64	vitamin_D_receptor	94,112	Cdx-2	vitamin D receptor	1045	7421	Gene	Gene	START_ENTITY|dobj|element element|nmod|gene gene|compound|END_ENTITY	The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin_D_receptor gene .
12968672	0	Cdx-2	0,5	vitamin_D_receptor	55,73	Cdx-2	vitamin D receptor	1045	7421	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|region region|nmod|gene gene|compound|END_ENTITY	Cdx-2 polymorphism in the promoter region of the human vitamin_D_receptor gene determines susceptibility to fracture in the elderly .
16362455	0	Cdx-2	15,20	vitamin_D_receptor	41,59	Cdx-2	vitamin D receptor	1045	7421	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Effects of the Cdx-2 polymorphism of the vitamin_D_receptor gene and lifestyle factors on bone_mineral_density in a representative sample of Japanese women : the Japanese Population-based Osteoporosis -LRB- JPOS -RRB- Study .
23026509	0	Cdx-2	25,30	vitamin_D_receptor	51,69	Cdx-2	vitamin D receptor	1045	7421	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Vitamin_D status and the Cdx-2 polymorphism of the vitamin_D_receptor gene are determining factors of bone mineral density in young healthy postmenopausal women .
27067904	0	Cdx-2	19,24	vitamin_D_receptor	51,69	Cdx-2	vitamin D receptor	1045	7421	Gene	Gene	role|nmod|START_ENTITY I|nsubj|role I|dobj|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Regulatory role of Cdx-2 and Taq I polymorphism of vitamin_D_receptor gene on chemokine expression in pulmonary_tuberculosis .
9933478	0	Cdx-2	39,44	vitamin_D_receptor	55,73	Cdx-2	vitamin D receptor	1045	7421	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The caudal-related homeodomain protein Cdx-2 regulates vitamin_D_receptor gene expression in the small intestine .
11997022	0	Cdx1	15,19	CDX2	97,101	Cdx1	CDX2	1044	1045	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|dep|effect effect|nmod|homeoprotein homeoprotein|compound|END_ENTITY	Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon_cancer cells ; opposite effect of the CDX2 homeoprotein .
15361487	0	Cdx1	0,4	Cdx2	91,95	Cdx1	Cdx2	12590(Tax:10090)	12591(Tax:10090)	Gene	Gene	intestinal_metaplasia|compound|START_ENTITY intestinal_metaplasia|dep|study study|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Cdx1 induced intestinal_metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic_mice .
19725873	0	Cdx1	35,39	Cdx2	11,15	Cdx1	Cdx2	12590(Tax:10090)	12591(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Transgenic Cdx2 induces endogenous Cdx1 in intestinal_metaplasia of Cdx2-transgenic mouse stomach .
15774940	0	Cdx1	78,82	intestinal_alkaline_phosphatase	27,58	Cdx1	intestinal alkaline phosphatase	1044	248	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of intestinal_alkaline_phosphatase gene expression by Cdx1 and Cdx2 .
15361487	0	Cdx2	91,95	Cdx1	0,4	Cdx2	Cdx1	12591(Tax:10090)	12590(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY study|nmod|transgenic_mice intestinal_metaplasia|dep|study intestinal_metaplasia|compound|END_ENTITY	Cdx1 induced intestinal_metaplasia in the transgenic mouse stomach : comparative study with Cdx2 transgenic_mice .
19725873	0	Cdx2	11,15	Cdx1	35,39	Cdx2	Cdx1	12591(Tax:10090)	12590(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Transgenic Cdx2 induces endogenous Cdx1 in intestinal_metaplasia of Cdx2-transgenic mouse stomach .
18495206	0	Cdx2	9,13	Cdx2	97,101	Cdx2	Cdx2	1045	1045	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Aberrant Cdx2 expression in endometrial lesions with squamous differentiation : important role of Cdx2 in squamous morula formation .
18495206	0	Cdx2	97,101	Cdx2	9,13	Cdx2	Cdx2	1045	1045	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Aberrant Cdx2 expression in endometrial lesions with squamous differentiation : important role of Cdx2 in squamous morula formation .
20351696	0	Cdx2	35,39	HB-EGF	19,25	Cdx2	HB-EGF	1045	1839	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Fibroblast-derived HB-EGF promotes Cdx2 expression in esophageal squamous cells .
16831200	0	Cdx2	37,41	Math1	112,117	Cdx2	Math1	1045	474	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The intestine-specific_homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1 .
26268420	0	Cdx2	51,55	Schlafen_3	0,10	Cdx2	Schlafen 3	66019(Tax:10116)	501712(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Mediates|dobj|Effects Mediates|nsubj|END_ENTITY	Schlafen_3 Mediates the Differentiating Effects of Cdx2 in Rat IEC-Cdx2L1 Enterocytes .
10611160	0	Cdx2	24,28	lactase	39,46	Cdx2	lactase	1045	3938	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation .
17183676	0	Cdx4	0,4	Hoxa9	27,32	Cdx4	Hoxa9	1046	3205	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells .
16843491	0	CeBRC-2	0,7	RAD-51	39,45	CeBRC-2	RAD-51	175962(Tax:6239)	177914(Tax:6239)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing .
11483763	0	Ceacam1	27,34	MHVR	36,40	Ceacam1	MHVR	26365(Tax:10090)	26365(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Targeted disruption of the Ceacam1 -LRB- MHVR -RRB- gene leads to reduced susceptibility of mice to mouse_hepatitis_virus_infection .
16619040	0	Ceacam1	75,82	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	16,73	Ceacam1	carcinoembryonic antigen-related cell adhesion molecule 1	26365(Tax:10090)	26365(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion of the carcinoembryonic_antigen-related_cell_adhesion_molecule_1 -LRB- Ceacam1 -RRB- gene contributes to colon_tumor progression in a murine model of carcinogenesis .
11694347	0	Ceacam1	58,65	cell-cell_adhesion_molecule-1	27,56	Ceacam1	cell-cell adhesion molecule-1	634	634	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Androgen regulation of the cell-cell_adhesion_molecule-1 -LRB- Ceacam1 -RRB- gene .
7983002	0	Ced-3	98,103	CPP32	0,5	Ced-3	CPP32	178272(Tax:6239)	836	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	CPP32 , a novel human apoptotic protein with homology to Caenorhabditis_elegans cell death protein Ced-3 and mammalian interleukin-1_beta-converting_enzyme .
22899848	0	Celf1	0,5	dmrt2a	20,26	Celf1	dmrt2a	58137(Tax:7955)	30129(Tax:7955)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Celf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development .
24710090	0	Cell_Division_Autoantigen_1	8,35	CDA1	37,41	Cell Division Autoantigen 1	CDA1	64061	64061	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Cell_Division_Autoantigen_1 -LRB- CDA1 -RRB- in Cell Proliferation and Fibrosis .
19932761	0	Cellular_FLICE-inhibitory_protein	0,33	c-FLIP	35,41	Cellular FLICE-inhibitory protein	c-FLIP	8837	8837	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Cellular_FLICE-inhibitory_protein -LRB- c-FLIP -RRB- signalling : a key regulator of receptor-mediated apoptosis in physiologic context and in cancer .
26900151	0	Cellular_Retinol-Binding_Protein_1	55,89	CRBP1	91,96	Cellular Retinol-Binding Protein 1	CRBP1	5947	5947	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Ligand Binding Induces Conformational Changes in Human Cellular_Retinol-Binding_Protein_1 -LRB- CRBP1 -RRB- revealed by atomic resolution crystal structures .
11603220	0	Cellular_apoptosis_susceptibility_gene	0,38	Bcl-2	93,98	Cellular apoptosis susceptibility gene	Bcl-2	1434	596	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Cellular_apoptosis_susceptibility_gene expression in endometrial_carcinoma : correlation with Bcl-2 , Bax , and caspase-3 expression and outcome .
21996446	0	Cellular_retinaldehyde-binding_protein	0,38	Pax6	102,106	Cellular retinaldehyde-binding protein	Pax6	6017	5080	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cellular_retinaldehyde-binding_protein -LRB- CRALBP -RRB- is a direct downstream target of transcription factor Pax6 .
16912187	0	Cellular_retinoic_acid-binding_protein_II	0,41	MycN	80,84	Cellular retinoic acid-binding protein II	MycN	1382	4613	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cellular_retinoic_acid-binding_protein_II is a direct transcriptional target of MycN in neuroblastoma .
22982089	0	Cellular_retinoic_acid_binding_protein_I	0,40	ERK1/2	84,90	Cellular retinoic acid binding protein I	ERK1/2	1381	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Cellular_retinoic_acid_binding_protein_I mediates rapid non-canonical activation of ERK1/2 by all-trans_retinoic_acid .
12883492	0	Cellular_retinol-binding_protein-1	0,34	beta-catenin	79,91	Cellular retinol-binding protein-1	beta-catenin	5947	1499	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Cellular_retinol-binding_protein-1 in hepatocellular_carcinoma correlates with beta-catenin , Ki-67 index , and patient survival .
21353556	0	Cenp-C	18,24	Mis12	32,37	Cenp-C	Mis12	1060	79003	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore .
15923660	0	Centaurin-alpha1	0,16	KIF13B	63,69	Centaurin-alpha1	KIF13B	171097(Tax:10116)	305967(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B .
12565890	0	Centaurin-alpha_1	0,17	nucleolin	55,64	Centaurin-alpha 1	nucleolin	11033	4691	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Centaurin-alpha_1 associates in vitro and in vivo with nucleolin .
26354417	0	Centrin_3	0,9	Mps1	41,45	Centrin 3	Mps1	1070	7272	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Centrin_3 is an inhibitor of centrosomal Mps1 and antagonizes Centrin_2 function .
16888627	0	Centriolin	28,38	Nud1p	0,5	Centriolin	Nud1p	11064	854555(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Nud1p , the yeast homolog of Centriolin , regulates spindle pole body inheritance in meiosis .
19427213	0	Centrocortin	0,12	centrosomin	29,40	Centrocortin	centrosomin	35330(Tax:7227)	36491(Tax:7227)	Gene	Gene	cooperates|compound|START_ENTITY cooperates|nmod|END_ENTITY	Centrocortin cooperates with centrosomin to organize Drosophila embryonic cleavage furrows .
26372373	0	Centromere-Associated_Protein-E	21,52	CENP-E	54,60	Centromere-Associated Protein-E	CENP-E	1062	1062	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Synthetic Studies on Centromere-Associated_Protein-E -LRB- CENP-E -RRB- Inhibitors : 2 .
22184120	0	Centrosomal_protein_55	0,22	Cep55	24,29	Centrosomal protein 55	Cep55	55165	55165	Gene	Gene	stability|amod|START_ENTITY stability|appos|END_ENTITY	Centrosomal_protein_55 -LRB- Cep55 -RRB- stability is negatively regulated by p53 protein through Polo-like_kinase_1 -LRB- Plk1 -RRB- .
21059844	0	Cep152	0,6	Plk4	45,49	Cep152	Plk4	22995	10733	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|scaffold scaffold|nmod|recruitment recruitment|nmod|END_ENTITY	Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome .
21059850	0	Cep152	0,6	Plk4	22,26	Cep152	Plk4	22995	10733	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cep152 interacts with Plk4 and is required for centriole duplication .
15616186	0	Cep170	39,45	Polo-like_kinase_1	61,79	Cep170	Polo-like kinase 1	9859	5347	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The forkhead-associated domain protein Cep170 interacts with Polo-like_kinase_1 and serves as a marker for mature centrioles .
26012549	0	Cep192	80,86	Polo-Like_Kinase_1	33,51	Cep192	Polo-Like Kinase 1	55125	5347	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Bimodal Interaction of Mammalian Polo-Like_Kinase_1 and a Centrosomal Scaffold , Cep192 , in the Regulation of Bipolar Spindle Formation .
25998387	0	Cep290	13,19	DDA3	0,4	Cep290	DDA3	80184	84722	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	DDA3 targets Cep290 into the centrosome to regulate spindle positioning .
24356449	0	Cep290	54,60	SSX2IP	39,45	Cep290	SSX2IP	80184	117178	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone .
22184120	0	Cep55	24,29	Centrosomal_protein_55	0,22	Cep55	Centrosomal protein 55	55165	55165	Gene	Gene	stability|appos|START_ENTITY stability|amod|END_ENTITY	Centrosomal_protein_55 -LRB- Cep55 -RRB- stability is negatively regulated by p53 protein through Polo-like_kinase_1 -LRB- Plk1 -RRB- .
19638580	0	Cep55	65,70	Pin1	30,34	Cep55	Pin1	55165	5300	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55 .
21406398	0	Cep63	0,5	Cdk1	15,19	Cep63	Cdk1	80254	983	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Cep63 recruits Cdk1 to the centrosome : implications for regulation of mitotic entry , centrosome amplification , and genome maintenance .
25643699	0	Cep63	0,5	Cdk1	15,19	Cep63	Cdk1	80254	983	Gene	Gene	Recruits|compound|START_ENTITY END_ENTITY|nsubj|Recruits	Cep63 Recruits Cdk1 to the Centrosome-Letter .
25704143	0	Cep68	0,5	Nek2	26,30	Cep68	Nek2	23177	4751	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cep68 can be regulated by Nek2 and SCF complex .
19003160	0	Cephalic_hedgehog	0,17	Sox17	54,59	Cephalic hedgehog	Sox17	378539(Tax:8355)	397966(Tax:8355)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Cephalic_hedgehog expression is regulated directly by Sox17 in endoderm development of Xenopus_laevis .
18691014	0	Ceramide_kinase	0,15	cPLA2alpha	45,55	Ceramide kinase	cPLA2alpha	64781	5321	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	Ceramide_kinase and the ceramide-1-phosphate / cPLA2alpha interaction as a therapeutic target .
19892737	0	Ceramide_kinase	0,15	phospholipase_C	26,41	Ceramide kinase	phospholipase C	40640(Tax:7227)	31376(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Ceramide_kinase regulates phospholipase_C and phosphatidylinositol 4 , 5 , bisphosphate in phototransduction .
21713147	0	Cerb-B2	11,18	Her-2_neu	0,9	Cerb-B2	Her-2 neu	2064	2064	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Her-2_neu -LRB- Cerb-B2 -RRB- expression in fine needle aspiration samples of breast_carcinoma : A pilot study comparing FISH , CISH and immunocytochemistry .
23306200	0	Ceruloplasmin	0,13	myeloperoxidase	44,59	Ceruloplasmin	myeloperoxidase	12870(Tax:10090)	4353	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Ceruloplasmin is an endogenous inhibitor of myeloperoxidase .
26148512	0	Cezanne	0,7	HIF2a	33,38	Cezanne	HIF2a	56957	2034	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Cezanne regulates E2F1-dependent HIF2a expression .
23564640	0	Cezanne	0,7	TRAF6	86,91	Cezanne	TRAF6	229603(Tax:10090)	22034(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination .
24378376	0	Cftr	49,53	CFTR	21,25	Cftr	CFTR	12638(Tax:10090)	12638(Tax:10090)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Marked repression of CFTR mRNA in the transgenic Cftr -LRB- tm1kth -RRB- mouse model .
20806177	0	CgA	35,38	chromogranin_A	19,33	CgA	chromogranin A	1113	1113	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	The differences in chromogranin_A -LRB- CgA -RRB- concentrations measured in serum and in plasma by IRMA and ELISA methods .
25754282	0	CgA	30,33	chromogranin_A	14,28	CgA	chromogranin A	1113	1113	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Comparison of chromogranin_A -LRB- CgA -RRB- levels in serum and plasma -LRB- EDTA2K -RRB- and the respective reference ranges in healthy males .
3814131	0	CgA	35,38	chromogranin_A	19,33	CgA	chromogranin A	1113	1113	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for human chromogranin_A -LRB- CgA -RRB- is located on chromosome 14 .
10369418	0	Cgamma1	42,49	CD40_ligand	62,73	Cgamma1	CD40 ligand	107573(Tax:10090)	21947(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the germline immunoglobulin Cgamma1 promoter by CD40_ligand and IL-4 : dual role for tandem NF-kappaB binding sites .
18561487	0	ChAc	52,56	choline_acetyltransferase	25,50	ChAc	choline acetyltransferase	395314(Tax:9031)	395314(Tax:9031)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Developmental changes of choline_acetyltransferase -LRB- ChAc -RRB- activity in chick embryo spinal and sympathetic ganglia .
24055811	0	ChREBP	42,48	Flightless_I_homolog	0,20	ChREBP	Flightless I homolog	51085	2314	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Flightless_I_homolog negatively regulates ChREBP activity in cancer cells .
17379603	0	ChREBP	152,158	SREBP-1	93,100	ChREBP	SREBP-1	51085	6720	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response_element-binding_protein -LRB- ChREBP -RRB- activation .
20615868	0	ChREBP	122,128	carbohydrate-response_element-binding_protein	75,120	ChREBP	carbohydrate-response element-binding protein	58805(Tax:10090)	58805(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Thyroid_hormone_receptor_beta -LRB- TRbeta -RRB- and liver X receptor -LRB- LXR -RRB- regulate carbohydrate-response_element-binding_protein -LRB- ChREBP -RRB- expression in a tissue-selective manner .
23811343	0	ChSy-1	26,32	chondroitin_synthase-1	2,24	ChSy-1	chondroitin synthase-1	22856	22856	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A chondroitin_synthase-1 -LRB- ChSy-1 -RRB- missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1 .
8755482	0	Chapsyn-110	63,74	PSD-95	92,98	Chapsyn-110	PSD-95	64053(Tax:10116)	29495(Tax:10116)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110 , a member of the PSD-95 family of proteins .
2160563	0	Charcot-Leyden_crystal_protein	32,62	lysophospholipase	64,81	Charcot-Leyden crystal protein	lysophospholipase	1178	151056	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of Charcot-Leyden_crystal_protein -LRB- lysophospholipase -RRB- to intracytoplasmic crystals in tumor cells of primary solid and papillary_epithelial_neoplasm_of_the_pancreas .
2455566	0	Charcot-Leyden_crystal_protein	36,66	lysophospholipase	68,85	Charcot-Leyden crystal protein	lysophospholipase	1178	151056	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of the Charcot-Leyden_crystal_protein -LRB- lysophospholipase -RRB- to a distinct crystalloid-free granule population in mature human eosinophils .
18021315	0	Charcot-Marie-Tooth_type_4A_disease	67,102	GDAP1	19,24	Charcot-Marie-Tooth type 4A disease	GDAP1	54332	54332	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cell expression of GDAP1 in the nervous system and pathogenesis of Charcot-Marie-Tooth_type_4A_disease .
22033927	0	Chd1	70,74	chromodomain_helicase_DNA-binding_protein_1	25,68	Chd1	chromodomain helicase DNA-binding protein 1	856911(Tax:4932)	856911(Tax:4932)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Crystal structure of the chromodomain_helicase_DNA-binding_protein_1 -LRB- Chd1 -RRB- DNA-binding domain in complex with DNA .
26928066	0	Chd7	0,4	Sox10	21,26	Chd7	Sox10	320790(Tax:10090)	20665(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination .
21532573	0	Chd7	21,25	Sox2	0,4	Chd7	Sox2	55636	6657	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes .
18388733	0	Che-1	0,5	cyclin-dependent_kinase_5	15,40	Che-1	cyclin-dependent kinase 5	26574	1020	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Che-1 enhances cyclin-dependent_kinase_5 expression and interacts with the active kinase-complex .
17157788	0	Che-1	0,5	p53	60,63	Che-1	p53	26574	7157	Gene	Gene	phosphorylation|amod|START_ENTITY activates|nsubj|phosphorylation activates|dobj|transcription transcription|compound|END_ENTITY	Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint .
17189183	0	Che-1	68,73	p53	81,84	Che-1	p53	26574	7157	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter .
20708154	0	Che-1	0,5	p53	56,59	Che-1	p53	26574	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|sustaining sustaining|dobj|transcription transcription|compound|END_ENTITY	Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation .
27012205	0	Che-1	0,5	p53	78,81	Che-1	p53	26574	7157	Gene	Gene	silencing|amod|START_ENTITY induces|nsubj|silencing induces|advcl|inhibiting inhibiting|dobj|expression expression|compound|END_ENTITY	Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression .
15526025	0	Checkpoint_kinase_1	0,19	CHK1	21,25	Checkpoint kinase 1	CHK1	1111	1111	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Checkpoint_kinase_1 -LRB- CHK1 -RRB- protein and mRNA expression is downregulated in aggressive variants of human lymphoid_neoplasms .
24464213	0	Checkpoint_kinase_1	0,19	miR-497	47,54	Checkpoint kinase 1	miR-497	1111	574456	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Checkpoint_kinase_1 is negatively regulated by miR-497 in hepatocellular_carcinoma .
20363975	0	ChemR23	44,51	Chemerin	0,8	ChemR23	Chemerin	14747(Tax:10090)	71660(Tax:10090)	Gene	Gene	manner|amod|START_ENTITY phagocytosis|nmod|manner promote|dobj|phagocytosis promote|nsubj|peptides peptides|compound|END_ENTITY	Chemerin peptides promote phagocytosis in a ChemR23 - and Syk-dependent manner .
19540290	0	ChemR23	71,78	chemerin	27,35	ChemR23	chemerin	14747(Tax:10090)	71660(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|analog analog|compound|END_ENTITY	Identification of a stable chemerin analog with potent activity toward ChemR23 .
21192818	0	ChemR23	37,44	chemerin	124,132	ChemR23	chemerin	1240	5919	Gene	Gene	express|dobj|START_ENTITY express|parataxis|promotes promotes|nmod|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
21192818	0	ChemR23	37,44	chemerin	124,132	ChemR23	chemerin	1240	5919	Gene	Gene	express|dobj|START_ENTITY express|parataxis|promotes promotes|nmod|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
21192818	0	ChemR23	59,66	chemerin	124,132	ChemR23	chemerin	1240	5919	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
21192818	0	ChemR23	59,66	chemerin	124,132	ChemR23	chemerin	1240	5919	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
25637017	0	ChemR23	0,7	chemerin	26,34	ChemR23	chemerin	1240	5919	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	ChemR23 , the receptor for chemerin and resolvin_E1 , is expressed and functional on M1 but not on M2 macrophages .
25637017	0	ChemR23	0,7	chemerin	26,34	ChemR23	chemerin	1240	5919	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	ChemR23 , the receptor for chemerin and resolvin_E1 , is expressed and functional on M1 but not on M2 macrophages .
22037282	0	Chemerin	0,8	CCL2	17,21	Chemerin	CCL2	5919	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid_arthritis and osteoarthritis .
22037282	0	Chemerin	0,8	CCL2	17,21	Chemerin	CCL2	5919	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid_arthritis and osteoarthritis .
24758146	0	Chemerin	0,8	CCL2	57,61	Chemerin	CCL2	71660(Tax:10090)	20296(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|production production|compound|END_ENTITY	Chemerin suppresses murine allergic_asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells .
26363224	0	Chemerin	24,32	CMKLR1	0,6	Chemerin	CMKLR1	5919	1240	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	CMKLR1 and GPR1 Mediate Chemerin Signaling Through the RhoA/ROCK Pathway .
20363975	0	Chemerin	0,8	ChemR23	44,51	Chemerin	ChemR23	71660(Tax:10090)	14747(Tax:10090)	Gene	Gene	peptides|compound|START_ENTITY promote|nsubj|peptides promote|dobj|phagocytosis phagocytosis|nmod|manner manner|amod|END_ENTITY	Chemerin peptides promote phagocytosis in a ChemR23 - and Syk-dependent manner .
21766603	0	Chemerin	1,9	RBP4	11,15	Chemerin	RBP4	5919	5950	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- Chemerin , RBP4 and vaspin -RSB- .
21766603	0	Chemerin	1,9	RBP4	11,15	Chemerin	RBP4	5919	5950	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- Chemerin , RBP4 and vaspin -RSB- .
24779513	0	Chemerin	0,8	chemerin	100,108	Chemerin	chemerin	5919	5919	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Chemerin and CMKLR1 expression in human arteries and periadventitial fat : a possible role for local chemerin in atherosclerosis ?
24779513	0	Chemerin	0,8	chemerin	100,108	Chemerin	chemerin	5919	5919	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Chemerin and CMKLR1 expression in human arteries and periadventitial fat : a possible role for local chemerin in atherosclerosis ?
25390351	0	Chemokine_Receptor	18,36	CCR8	43,47	Chemokine Receptor	CCR8	7852	1237	Gene	Gene	Gene|compound|START_ENTITY Expression|nmod|Gene Expression|appos|END_ENTITY	Expression of the Chemokine_Receptor Gene , CCR8 , is Associated With DUSP22 Rearrangements in Anaplastic_Large_Cell_Lymphoma .
25149650	0	Chemokine_Receptor_4	22,42	CXCR4	43,48	Chemokine Receptor 4	CXCR4	12767(Tax:10090)	12767(Tax:10090)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Anticancer Effects of Chemokine_Receptor_4 -LRB- CXCR4 -RRB- Gene Silenced by CXCR4-siRNA in Nude_Mice Model of Ovarian_Cancer .
16320328	0	Chemokine_receptor	0,18	CCR2	19,23	Chemokine receptor	CCR2	7852	729230	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Chemokine_receptor CCR2 expression by systemic_sclerosis fibroblasts : evidence for autocrine regulation of myofibroblast differentiation .
11145678	0	Chemokine_receptor	0,18	CD4	46,49	Chemokine receptor	CD4	7852	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Chemokine_receptor expression and function in CD4 + T lymphocytes with regulatory activity .
15837989	0	Chemokine_receptor	0,18	CXCR4	19,24	Chemokine receptor	CXCR4	7852	7852	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Chemokine_receptor CXCR4 expression in colorectal_cancer patients increases the risk for recurrence and for poor survival .
23852305	0	Chemokine_receptor_5	0,20	CCR5	22,26	Chemokine receptor 5	CCR5	1234	1234	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Chemokine_receptor_5 -LRB- CCR5 -RRB- polymorphism in chronic hepatitis_B patients treated with three different nucleos -LRB- t -RRB- ide analogues .
24912620	0	Chemokine_receptor_7	0,20	matrix_metalloproteinase-9	137,163	Chemokine receptor 7	matrix metalloproteinase-9	1236	4318	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Chemokine_receptor_7 enhances cell chemotaxis and migration of metastatic squamous_cell_carcinoma_of_head_and_neck through activation of matrix_metalloproteinase-9 .
16556729	0	Chga	41,45	chromogranin_a	25,39	Chga	chromogranin a	12652(Tax:10090)	12652(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Targeted ablation of the chromogranin_a -LRB- Chga -RRB- gene : normal neuroendocrine dense-core secretory granules and increased expression of other granins .
20729505	0	Chga	168,172	chromogranin_a	152,166	Chga	chromogranin a	12652(Tax:10090)	12652(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of reactive oxygen species in hyperadrenergic hypertension : biochemical , physiological , and pharmacological evidence from targeted ablation of the chromogranin_a -LRB- Chga -RRB- gene .
25597954	0	Chip	0,4	Notch	31,36	Chip	Notch	37837(Tax:7227)	31293(Tax:7227)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Chip physically interacts with Notch and their stoichiometry is critical for Notch function in wing development and cell proliferation in Drosophila .
27027937	0	Chit1	65,70	Chitotriosidase	48,63	Chit1	Chitotriosidase	1118	1118	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Nasal Microbiome Composition Is Associated with Chitotriosidase -LRB- Chit1 -RRB- Activity in Adult Hutterites .
26528713	0	Chitinase-3-Like-1	20,38	CHI3L1	12,18	Chitinase-3-Like-1	CHI3L1	12654(Tax:10090)	12654(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of CHI3L1 -LRB- Chitinase-3-Like-1 -RRB- in the Pathogenesis of Infections in Burns in a Mouse Model .
18281018	0	Chitinase-3-like_1	0,18	CHI3L1	20,26	Chitinase-3-like 1	CHI3L1	1116	1116	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chitinase-3-like_1 -LRB- CHI3L1 -RRB- gene and schizophrenia : genetic association and a potential functional mechanism .
26431492	0	Chitinase_3-like_1	0,18	S100A9	157,163	Chitinase 3-like 1	S100A9	12654(Tax:10090)	20202(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Chitinase_3-like_1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated_cancer by regulating S100A9 .
27027937	0	Chitotriosidase	48,63	Chit1	65,70	Chitotriosidase	Chit1	1118	1118	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Nasal Microbiome Composition Is Associated with Chitotriosidase -LRB- Chit1 -RRB- Activity in Adult Hutterites .
15261462	0	Chk	49,52	Csk_homologous_kinase	26,47	Chk	Csk homologous kinase	4145	4145	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Complex regulation of the Csk_homologous_kinase -LRB- Chk -RRB- by IL-4 family cytokines and IFN-gamma in human peripheral blood monocytes .
15190204	0	Chk1	53,57	ATR	0,3	Chk1	ATR	1111	545	Gene	Gene	regulate|dobj|START_ENTITY regulate|advmod|END_ENTITY	ATR , Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage .
16186122	0	Chk1	19,23	ATR	108,111	Chk1	ATR	398191(Tax:8355)	398197(Tax:8355)	Gene	Gene	Phosphorylation|nmod|START_ENTITY requires|nsubj|Phosphorylation requires|dobj|binding binding|nmod|END_ENTITY	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
16186122	0	Chk1	19,23	ATR	50,53	Chk1	ATR	398191(Tax:8355)	398197(Tax:8355)	Gene	Gene	START_ENTITY|nmod|ATM ATM|appos|END_ENTITY	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
16880517	0	Chk1	70,74	ATR	48,51	Chk1	ATR	1111	545	Gene	Gene	activation|amod|START_ENTITY signaling|nmod|activation END_ENTITY|acl|signaling	Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation .
17210576	0	Chk1	83,87	ATR	60,63	Chk1	ATR	1111	545	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Phosphatase_type_2A-dependent and - independent pathways for ATR phosphorylation of Chk1 .
19828454	0	Chk1	60,64	ATR	72,75	Chk1	ATR	1111	545	Gene	Gene	START_ENTITY|nmod|checkpoint checkpoint|compound|END_ENTITY	Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR -LRB- ataxia_telangiectasia-mutated and rad3-related -RRB- checkpoint kinase .
20233725	0	Chk1	49,53	ATR	73,76	Chk1	ATR	1111	545	Gene	Gene	phosphorylation|amod|START_ENTITY mediates|dobj|phosphorylation mediates|nmod|END_ENTITY	Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress .
21502314	0	Chk1	220,224	ATR	175,178	Chk1	ATR	1111	545	Gene	Gene	checkpoint_kinase_1|appos|START_ENTITY phosphorylation|nmod|checkpoint_kinase_1 phosphorylation|appos|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
23733185	0	Chk1	157,161	ATR	131,134	Chk1	ATR	1111	545	Gene	Gene	arrest|appos|START_ENTITY arrest|nmod|checkpoint_kinase_1 checkpoint_kinase_1|appos|END_ENTITY	4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia_telangiectasia mutated and Rad3-related protein -LRB- ATR -RRB- / checkpoint_kinase_1 -LRB- Chk1 -RRB- signaling pathway .
16186122	0	Chk1	19,23	ATRIP	99,104	Chk1	ATRIP	398191(Tax:8355)	496388(Tax:8355)	Gene	Gene	Phosphorylation|nmod|START_ENTITY requires|nsubj|Phosphorylation requires|dobj|binding binding|nmod|END_ENTITY	Phosphorylation of Chk1 by ATM - _ and_Rad3-related -LRB- ATR -RRB- in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP .
10859164	0	Chk1	0,4	Atr	49,52	Chk1	Atr	1111	545	Gene	Gene	kinase|nsubj|START_ENTITY kinase|acl:relcl|regulated regulated|nmod|END_ENTITY	Chk1 is an essential kinase that is regulated by Atr and required for the G -LRB- 2 -RRB- / M DNA damage checkpoint .
11069891	0	Chk1	42,46	Atr	16,19	Chk1	Atr	398191(Tax:8355)	398197(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY Requirement|nmod|phosphorylation Requirement|nmod|END_ENTITY	Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts .
18237113	0	Chk1	142,146	Cdc25B	80,86	Chk1	Cdc25B	1111	994	Gene	Gene	kinases|amod|START_ENTITY overlap|nmod|kinases provides|parataxis|overlap provides|nmod|pattern pattern|nmod|END_ENTITY	NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo : full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro .
11090622	0	Chk1	56,60	Claspin	0,7	Chk1	Claspin	398191(Tax:8355)	398192(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation protein|acl|required END_ENTITY|appos|protein	Claspin , a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts .
12545175	0	Chk1	75,79	Claspin	34,41	Chk1	Claspin	398191(Tax:8355)	398192(Tax:8355)	Gene	Gene	regulated|nmod|START_ENTITY mediate|dobj|regulated mediate|nsubj|motifs motifs|nmod|END_ENTITY	Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 .
15190204	0	Chk1	53,57	Claspin	5,12	Chk1	Claspin	1111	63967	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	ATR , Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage .
15279790	0	Chk1	24,28	Claspin	0,7	Chk1	Claspin	1111	63967	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Claspin , a regulator of Chk1 in DNA replication stress pathway .
15371427	0	Chk1	77,81	Claspin	0,7	Chk1	Claspin	398191(Tax:8355)	398192(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY collaborate|nmod|activation collaborate|nsubj|END_ENTITY	Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1 .
16618813	0	Chk1	80,84	Claspin	66,73	Chk1	Claspin	398191(Tax:8355)	398192(Tax:8355)	Gene	Gene	bound|dobj|START_ENTITY bound|nsubj|requirement requirement|nmod|Xmus101 Xmus101|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling .
16880517	0	Chk1	70,74	Claspin	0,7	Chk1	Claspin	1111	63967	Gene	Gene	activation|amod|START_ENTITY signaling|nmod|activation ATR|acl|signaling direct|dobj|ATR operates|xcomp|direct operates|nsubj|END_ENTITY	Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation .
16885021	0	Chk1	48,52	Claspin	15,22	Chk1	Claspin	1111	63967	Gene	Gene	activation|amod|START_ENTITY restrains|dobj|activation restrains|nsubj|Destruction Destruction|nmod|END_ENTITY	Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress .
16963448	0	Chk1	70,74	Claspin	40,47	Chk1	Claspin	1111	63967	Gene	Gene	phosphorylated|nmod|START_ENTITY phosphorylated|nsubjpass|motifs motifs|nmod|END_ENTITY	Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function .
18331829	0	Chk1	79,83	Claspin	0,7	Chk1	Claspin	396486(Tax:9031)	428223(Tax:9031)	Gene	Gene	distinct|nmod|START_ENTITY kinase|amod|distinct phosphorylated|nmod|kinase phosphorylated|nsubjpass|END_ENTITY	Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1 .
21680713	0	Chk1	112,116	Claspin	51,58	Chk1	Claspin	1111	63967	Gene	Gene	activation|nmod|START_ENTITY necessary|nmod|activation residues|amod|necessary kinase|nmod|residues kinase|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1 .
26082189	0	Chk1	45,49	Claspin	23,30	Chk1	Claspin	1111	63967	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress .
19276361	0	Chk1	13,17	DDB1	0,4	Chk1	DDB1	1111	1642	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress .
23954429	0	Chk1	0,4	E2F6	14,18	Chk1	E2F6	1111	1876	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription .
19716789	0	Chk1	33,37	Fbx6	18,22	Chk1	Fbx6	1111	26270	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress .
25809478	0	Chk1	59,63	MCM3	50,54	Chk1	MCM3	1111	4172	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of mini-chromosome_maintenance 3 -LRB- MCM3 -RRB- by Chk1 negatively regulates DNA replication and checkpoint activation .
22231448	0	Chk1	0,4	Metnase	24,31	Chk1	Metnase	1111	6419	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart .
25024738	0	Chk1	43,47	Metnase	25,32	Chk1	Metnase	1111	6419	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	The DNA repair component Metnase regulates Chk1 stability .
15107832	0	Chk1	115,119	Tax	35,38	Chk1	Tax	1111	6900	Gene	Gene	mediated|nmod|START_ENTITY G2_arrest|acl|mediated interacts|dobj|G2_arrest interacts|nsubj|END_ENTITY	Human_T-cell_leukemia_virus_type_1 Tax interacts with Chk1 and attenuates DNA-damage induced G2_arrest mediated by Chk1 .
15107832	0	Chk1	54,58	Tax	35,38	Chk1	Tax	1111	6900	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human_T-cell_leukemia_virus_type_1 Tax interacts with Chk1 and attenuates DNA-damage induced G2_arrest mediated by Chk1 .
11251070	0	Chk1	31,35	Wee1	23,27	Chk1	Wee1	398191(Tax:8355)	398017(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive regulation of Wee1 by Chk1 and 14-3-3 proteins .
22529391	0	Chk1	52,56	checkpoint_kinase_1	31,50	Chk1	checkpoint kinase 1	1111	1111	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Kinase-independent function of checkpoint_kinase_1 -LRB- Chk1 -RRB- in the replication of damaged DNA .
12963733	0	Chk1	87,91	claspin	15,22	Chk1	claspin	398191(Tax:8355)	398192(Tax:8355)	Gene	Gene	domain|nmod|START_ENTITY site|nmod|domain interacts|nmod|site interacts|nsubj|END_ENTITY	Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation .
16123041	0	Chk1	63,67	claspin	12,19	Chk1	claspin	1111	63967	Gene	Gene	pathway|amod|START_ENTITY inhibits|dobj|pathway inhibits|nsubj|Cleavage Cleavage|nmod|END_ENTITY	Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway .
16501606	0	Chk1	0,4	claspin	29,36	Chk1	claspin	1111	63967	Gene	Gene	required|nsubjpass|START_ENTITY required|xcomp|maintain maintain|dobj|stability stability|compound|END_ENTITY	Chk1 is required to maintain claspin stability .
17638866	0	Chk1	23,27	estrogen_receptor	67,84	Chk1	estrogen receptor	1111	2099	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen_receptor / progesterone_receptor / HER-2 breast_carcinomas .
26471831	0	Chk1	70,74	mTORC1	0,6	Chk1	mTORC1	1111	382056(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition .
10673501	0	Chk1	41,45	p53	76,79	Chk1	p53	1111	7157	Gene	Gene	homologs|nmod|START_ENTITY phosphorylate|nsubj|homologs phosphorylate|dobj|END_ENTITY	The human homologs of checkpoint kinases Chk1 and Cds1 -LRB- Chk2 -RRB- phosphorylate p53 at multiple DNA damage-inducible sites .
11599922	0	Chk1	30,34	p53	49,52	Chk1	p53	12649(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Tissue-specific regulation of Chk1 expression by p53 .
16511572	0	Chk1	65,69	p53	84,87	Chk1	p53	1111	7157	Gene	Gene	phosphorylated|nmod|START_ENTITY phosphorylated|xcomp|resulting resulting|nmod|activation activation|compound|END_ENTITY	14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1 , resulting in p53 activation .
18281511	0	Chk1	129,133	p53	10,13	Chk1	p53	1111	7157	Gene	Gene	inhibitors|amod|START_ENTITY sensitive|nmod|inhibitors rendering|xcomp|sensitive induction|acl|rendering attenuates|dobj|induction attenuates|nsubj|END_ENTITY	Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest .
18281511	0	Chk1	129,133	p53	27,30	Chk1	p53	1111	7157	Gene	Gene	inhibitors|amod|START_ENTITY sensitive|nmod|inhibitors rendering|xcomp|sensitive induction|acl|rendering attenuates|dobj|induction attenuates|nsubj|p53 p53|acl|signaling signaling|nmod|tumors tumors|nummod|END_ENTITY	Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest .
18510930	0	Chk1	0,4	p53	75,78	Chk1	p53	1111	7157	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|damage damage|acl:relcl|bypasses bypasses|dobj|END_ENTITY	Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53 , Bcl-2 , and caspase-3 .
18642443	0	Chk1	0,4	p53	26,29	Chk1	p53	1111	7157	Gene	Gene	inhibition|amod|START_ENTITY activates|nsubj|inhibition activates|dobj|END_ENTITY	Chk1 inhibition activates p53 through p38_MAPK in tetraploid_cancer cells .
22134241	0	Chk1	93,97	p53	32,35	Chk1	p53	1111	7157	Gene	Gene	inhibition|nmod|START_ENTITY Selective|nmod|inhibition Selective|dobj|radiosensitization radiosensitization|nmod|cells cells|nummod|END_ENTITY	Selective radiosensitization of p53 mutant pancreatic_cancer cells by combined inhibition of Chk1 and PARP1 .
22430210	0	Chk1	23,27	p53	53,56	Chk1	p53	1111	7157	Gene	Gene	inhibition|amod|START_ENTITY lethality|nmod|inhibition combined|nsubj|lethality combined|nmod|END_ENTITY	Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells .
22825736	0	Chk1	4,8	p53	38,41	Chk1	p53	1111	7157	Gene	Gene	AZD7762|amod|START_ENTITY sensitises|nsubj|AZD7762 sensitises|dobj|cells cells|nummod|END_ENTITY	The Chk1 inhibitor AZD7762 sensitises p53 mutant breast_cancer cells to radiation in vitro and in vivo .
15601819	0	Chk1	66,70	p73	0,3	Chk1	p73	1111	7161	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|induction induction|amod|END_ENTITY	p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2 .
10973490	0	Chk2	45,49	Ataxia_telangiectasia-mutated	0,29	Chk2	Ataxia telangiectasia-mutated	11200	472	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Ataxia_telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro .
14701743	0	Chk2	0,4	BRCA1	24,29	Chk2	BRCA1	11200	672	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|break break|compound|END_ENTITY	Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair .
18804494	0	Chk2	22,26	BRCA1	0,5	Chk2	BRCA1	11200	672	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	BRCA1 is regulated by Chk2 in response to spindle damage .
25659039	0	Chk2	40,44	BRCA1	15,20	Chk2	BRCA1	11200	672	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection .
15485917	0	Chk2	110,114	Brca1	139,144	Chk2	Brca1	50883(Tax:10090)	12189(Tax:10090)	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Uterus_hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1 .
10531348	0	Chk2	20,24	Cds1	14,18	Chk2	Cds1	11200	1040	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of human Cds1 -LRB- Chk2 -RRB- kinase in DNA damage checkpoint and its regulation by p53 .
12717439	0	Chk2	0,4	E2F-1	15,20	Chk2	E2F-1	11200	1869	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Chk2 activates E2F-1 in response to DNA damage .
21070773	0	Chk2	40,44	Per3	0,4	Chk2	Per3	11200	8863	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Per3 , a circadian gene , is required for Chk2 activation in human cells .
16835227	0	Chk2	33,37	Promyelocytic_leukemia	0,22	Chk2	Promyelocytic leukemia	11200	5371	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Promyelocytic_leukemia activates Chk2 by mediating Chk2 autophosphorylation .
19375317	0	Chk2	36,40	TRF2	22,26	Chk2	TRF2	11200	7014	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage .
16798742	0	Chk2	138,142	Wip1	146,150	Chk2	Wip1	11200	8493	Gene	Gene	regulation|nmod|START_ENTITY required|nmod|regulation required|nmod|END_ENTITY	Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1 .
15044452	0	Chk2	23,27	p53	42,45	Chk2	p53	11200	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y .
22312557	0	Chk2	47,51	p53	22,25	Chk2	p53	11200	7157	Gene	Gene	Phosphorylation|compound|START_ENTITY END_ENTITY|nmod|Phosphorylation	The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor .
15736430	0	Chkl	0,4	BAD	30,33	Chkl	BAD	1120	572	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Chkl binds and phosphorylates BAD protein .
26877779	0	Chloride_Channel-3	104,122	P-glycoprotein	0,14	Chloride Channel-3	P-glycoprotein	1182	5243	Gene	Gene	Formation|nmod|START_ENTITY Formation|compound|END_ENTITY	P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride_Channel-3 .
8522159	0	Chloride_channel_2	0,18	Clc2	25,29	Chloride channel 2	Clc2	12724(Tax:10090)	12724(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chloride_channel_2 gene -LRB- Clc2 -RRB- maps to chromosome 16 of the mouse , extending a region of conserved synteny with human chromosome 3q .
11509018	0	Cholecystokinin	0,15	CCK	17,20	Cholecystokinin	CCK	885	885	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cholecystokinin -LRB- CCK -RRB- gene as a possible risk factor for smoking : a replication in two independent samples .
9372200	0	Cholecystokinin	0,15	Fos	24,27	Cholecystokinin	Fos	25298(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Cholecystokinin induces Fos expression in catecholaminergic neurons of the macaque monkey caudal medulla .
11478495	0	Cholecystokinin	0,15	S6_kinase	37,46	Cholecystokinin	S6 kinase	25298(Tax:10116)	83840(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Cholecystokinin activation of 70-kDa S6_kinase in exocrine pancreas .
2281080	0	Cholecystokinin	0,15	S6_kinase	48,57	Cholecystokinin	S6 kinase	25298(Tax:10116)	83840(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Cholecystokinin stimulates a specific ribosomal S6_kinase in rat pancreatic acini .
24009869	0	Cholecystokinin	22,37	STC-1	67,72	Cholecystokinin	STC-1	885	6781	Gene	Gene	Secretion|compound|START_ENTITY Secretion|nmod|Cells Cells|compound|END_ENTITY	Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells .
1371708	0	Cholecystokinin	0,15	c-fos	24,29	Cholecystokinin	c-fos	25298(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Cholecystokinin induces c-fos expression in hypothalamic oxytocinergic neurons projecting to the dorsal vagal complex .
15074389	0	Cholecystokinin	0,15	gastrin	25,32	Cholecystokinin	gastrin	397468(Tax:9823)	445524(Tax:9823)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Cholecystokinin inhibits gastrin secretion independently of paracrine somatostatin secretion in the pig .
15645696	0	Cholecystokinin	0,15	glucose_dependent_insulinotropic_peptide	17,57	Cholecystokinin	glucose dependent insulinotropic peptide	885	2695	Gene	Gene	START_ENTITY|appos|secretion secretion|amod|END_ENTITY	Cholecystokinin , glucose_dependent_insulinotropic_peptide and glucagon-like_peptide_1 secretion in children with anorexia_nervosa and simple_obesity .
14550255	0	Cholecystokinin	0,15	leptin	41,47	Cholecystokinin	leptin	885	3952	Gene	Gene	synthesizes|nsubj|START_ENTITY synthesizes|dobj|END_ENTITY	Cholecystokinin synthesizes and secretes leptin in isolated canine gastric chief cells .
16547500	0	Cholecystokinin-2_receptor	0,26	beta_1-integrin	59,74	Cholecystokinin-2 receptor	beta 1-integrin	887	3688	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Cholecystokinin-2_receptor modulates cell adhesion through beta_1-integrin in human pancreatic_cancer cells .
26043355	0	Cholecystokinin_2_Receptor	98,124	CCK2R	126,131	Cholecystokinin 2 Receptor	CCK2R	12426(Tax:10090)	12426(Tax:10090)	Gene	Gene	Ligand|compound|START_ENTITY Ligand|appos|END_ENTITY	Selective Tumor Targeting of Desacetyl_Vinblastine_Hydrazide and Tubulysin B via Conjugation to a Cholecystokinin_2_Receptor -LRB- CCK2R -RRB- Ligand .
23341962	0	Cholecystokinin_A_receptor	0,26	CCKAR	28,33	Cholecystokinin A receptor	CCKAR	886	886	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Cholecystokinin_A_receptor -LRB- CCKAR -RRB- gene variation is associated with language lateralization .
26694435	0	Cholesterol_Ester_Transfer_Protein	73,107	CETP	109,113	Cholesterol Ester Transfer Protein	CETP	1071	1071	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol_Ester_Transfer_Protein -LRB- CETP -RRB- Gene and Dyslipidemia in National Minority Adults in the Far West Region of China .
9058055	0	Choline_acetyltransferase	0,25	glutamate_decarboxylase	27,50	Choline acetyltransferase	glutamate decarboxylase	290567(Tax:10116)	24957(Tax:10116)	Gene	Gene	calcitonin|amod|START_ENTITY calcitonin|amod|END_ENTITY	Choline_acetyltransferase , glutamate_decarboxylase , tyrosine_hydroxylase , calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea-pig .
8817609	0	Choline_acetyltransferase	0,25	nerve_growth_factor	27,46	Choline acetyltransferase	nerve growth factor	290567(Tax:10116)	310738(Tax:10116)	Gene	Gene	changed|advmod|START_ENTITY changed|nsubjpass|levels levels|compound|END_ENTITY	Choline_acetyltransferase , nerve_growth_factor and cytokine levels are changed in congenitally hydrocephalic HTX rats .
9058055	0	Choline_acetyltransferase	0,25	tyrosine_hydroxylase	52,72	Choline acetyltransferase	tyrosine hydroxylase	290567(Tax:10116)	25085(Tax:10116)	Gene	Gene	calcitonin|amod|START_ENTITY calcitonin|amod|END_ENTITY	Choline_acetyltransferase , glutamate_decarboxylase , tyrosine_hydroxylase , calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea-pig .
18667431	0	Chondroitin_4-O-sulfotransferase-1	0,34	Wnt-3a	45,51	Chondroitin 4-O-sulfotransferase-1	Wnt-3a	58250(Tax:10090)	22416(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Chondroitin_4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate .
26356269	0	Chondroitin_Sulfate_Synthase_1	31,61	CHSY1	63,68	Chondroitin Sulfate Synthase 1	CHSY1	292999(Tax:10116)	292999(Tax:10116)	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|appos|END_ENTITY	TGF-b Induces Up-Regulation of Chondroitin_Sulfate_Synthase_1 -LRB- CHSY1 -RRB- in Nucleus Pulposus Cells Through MAPK Signaling .
26356269	0	Chondroitin_Sulfate_Synthase_1	31,61	TGF-b	0,5	Chondroitin Sulfate Synthase 1	TGF-b	292999(Tax:10116)	59086(Tax:10116)	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|compound|END_ENTITY	TGF-b Induces Up-Regulation of Chondroitin_Sulfate_Synthase_1 -LRB- CHSY1 -RRB- in Nucleus Pulposus Cells Through MAPK Signaling .
18484070	0	Chondroitin_sulfate_proteoglycan_2	0,34	CSPG2	36,41	Chondroitin sulfate proteoglycan 2	CSPG2	1462	1462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chondroitin_sulfate_proteoglycan_2 -LRB- CSPG2 -RRB- gene polymorphisms rs173686 and rs251124 are not associated with intracranial_aneurysms in Chinese Han nationality .
24845031	0	Chrebp	0,6	androgen_receptor	49,66	Chrebp	androgen receptor	51085	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Chrebp regulates the transcriptional activity of androgen_receptor in prostate_cancer .
8388667	0	Christmas_factor	37,53	coagulation_factor_IX	14,35	Christmas factor	coagulation factor IX	2158	2158	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of coagulation_factor_IX -LRB- Christmas_factor -RRB- in human hepatoma -LRB- HepG2 -RRB- cell cultures after retroviral vector-mediated transfer .
23637165	0	Chrna2	81,87	nicotinic_acetylcholine_receptor	34,66	Chrna2	nicotinic acetylcholine receptor	110902(Tax:10090)	11441(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Targeted deletion of the mouse a2 nicotinic_acetylcholine_receptor subunit gene -LRB- Chrna2 -RRB- potentiates nicotine-modulated behaviors .
12766617	0	Chrna4	54,60	alpha4	22,28	Chrna4	alpha4	11438(Tax:10090)	18518(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism in the alpha4 nicotinic receptor gene -LRB- Chrna4 -RRB- modulates enhancement of nicotinic receptor function by ethanol .
23109837	0	Chromatin_Assembly_Factor-1	38,65	p60	74,77	Chromatin Assembly Factor-1	p60	8208	7984	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|END_ENTITY	Tissue Microarray-Based Evaluation of Chromatin_Assembly_Factor-1 -LRB- CAF-1 -RRB- / p60 as Tumour Prognostic Marker .
10569138	0	Chromogranin-A	0,14	neuron-specific_enolase	76,99	Chromogranin-A	neuron-specific enolase	1113	2026	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Chromogranin-A as a serum marker for neuroendocrine_tumors : comparison with neuron-specific_enolase and correlation with immunohistochemical findings .
10710286	0	Chromogranin-B	0,14	IAPP	29,33	Chromogranin-B	IAPP	12653(Tax:10090)	15874(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Chromogranin-B regulation of IAPP and insulin secretion .
9253344	0	Chromogranin_A	0,14	neuron-specific_enolase	77,100	Chromogranin A	neuron-specific enolase	1113	2026	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Chromogranin_A as serum marker for neuroendocrine neoplasia : comparison with neuron-specific_enolase and the alpha-subunit of glycoprotein hormones .
22573892	0	Chs2	65,69	Dbf2	20,24	Chs2	Dbf2	852326(Tax:4932)	852984(Tax:4932)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast .
11918806	0	Chs4p	69,74	Shc1p	36,41	Chs4p	Shc1p	852218(Tax:4932)	856832(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Control of chitin synthesis through Shc1p , a functional homologue of Chs4p specifically induced during sporulation .
15576400	0	Chx10	0,5	Mitf	20,24	Chx10	Mitf	338917	4286	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity .
16446531	0	Chymase	0,7	CMA1	14,18	Chymase	CMA1	1215	1215	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chymase gene -LRB- CMA1 -RRB- polymorphisms in Dutch and Japanese sarcoidosis patients .
25667044	0	Chymase	0,7	mast_cell_protease_4	82,102	Chymase	mast cell protease 4	1215	17227(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Chymase inhibitor-sensitive synthesis of endothelin-1 _ -LRB- 1-31 -RRB- by recombinant mouse mast_cell_protease_4 and human chymase .
9256427	0	Chymase	0,7	stem_cell_factor	20,36	Chymase	stem cell factor	1215	4254	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Chymase cleavage of stem_cell_factor yields a bioactive , soluble product .
11591373	0	Ci-opsin1	0,9	opsin	29,34	Ci-opsin1	opsin	445754(Tax:7719)	445754(Tax:7719)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Ci-opsin1 , a vertebrate-type opsin gene , expressed in the larval ocellus of the ascidian Ciona_intestinalis .
16339192	0	Ci/Gli	22,28	Smo	15,18	Ci/Gli	Smo	43767(Tax:7227)	33196(Tax:7227)	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling from Smo to Ci/Gli : conservation and divergence of Hedgehog pathways from Drosophila to vertebrates .
23695883	0	Cia4	25,29	IL-6	55,59	Cia4	IL-6	140550(Tax:10116)	24498(Tax:10116)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Arthritis severity locus Cia4 is an early regulator of IL-6 , IL-1b , and NF-kB activators ' expression in pristane-induced_arthritis .
17462989	0	Cidea	30,35	peroxisome_proliferator-activated_receptor_alpha	137,185	Cidea	peroxisome proliferator-activated receptor alpha	12683(Tax:10090)	19013(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Cidea , mitochondrial cell_death-inducing_DNA_fragmentation_factor_alpha-like_effector_A , in mouse liver by peroxisome_proliferator-activated_receptor_alpha and gamma .
18845124	0	Cidec	30,35	PPARgamma2	39,49	Cidec	PPARgamma2	14311(Tax:10090)	19016(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of Cidec by PPARgamma2 in adipocyte .
16085496	0	Cik1	0,4	kar3	48,52	Cik1	kar3	855238(Tax:4932)	856263(Tax:4932)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends .
26567794	0	Ciliary_Neurotrophic_Factor	13,40	CNGB3	90,95	Ciliary Neurotrophic Factor	CNGB3	12803(Tax:10090)	30952(Tax:10090)	Gene	Gene	Function|compound|START_ENTITY Function|nmod|END_ENTITY	Intravitreal Ciliary_Neurotrophic_Factor Transiently Improves Cone-Mediated Function in a CNGB3 - / - Mouse Model of Achromatopsia .
25092804	0	Ciliary_neurotrophic_factor	0,27	CNTF	29,33	Ciliary neurotrophic factor	CNTF	1270	1270	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- activation of astrocytes decreases spreading depolarization susceptibility and increases potassium clearance .
15106827	0	Ciliary_neurotrophic_factor	0,27	Phox2a	39,45	Ciliary neurotrophic factor	Phox2a	25707(Tax:10116)	116648(Tax:10116)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Ciliary_neurotrophic_factor suppresses Phox2a in sympathetic neurons .
23038263	0	Ciliary_neurotrophic_factor	0,27	SOCS3	97,102	Ciliary neurotrophic factor	SOCS3	12803(Tax:10090)	12702(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Ciliary_neurotrophic_factor protects mice against streptozotocin-induced type 1 diabetes through SOCS3 : the role of STAT1/STAT3 ratio in b-cell death .
8783275	0	Ciliary_neurotrophic_factor	0,27	acetylcholinesterase	43,63	Ciliary neurotrophic factor	acetylcholinesterase	25707(Tax:10116)	83817(Tax:10116)	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Ciliary_neurotrophic_factor : regulation of acetylcholinesterase in skeletal muscle and distribution of messenger RNA encoding its receptor in synaptic versus extrasynaptic compartments .
12068002	0	Ciliary_neurotrophic_factor	0,27	connexin43	99,109	Ciliary neurotrophic factor	connexin43	1270	2697	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- in combination with its soluble receptor -LRB- CNTFRalpha -RRB- increases connexin43 expression and suppresses growth of C6_glioma cells .
19267906	0	Ciliary_neurotrophic_factor	0,27	cyclooxygenase-2	78,94	Ciliary neurotrophic factor	cyclooxygenase-2	12803(Tax:10090)	19225(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression , PGE2 release and interferon-gamma-induced CD40 in murine microglia .
11694760	0	Ciliary_neurotrophic_factor	0,27	gp130	31,36	Ciliary neurotrophic factor	gp130	25707(Tax:10116)	25205(Tax:10116)	Gene	Gene	START_ENTITY|appos|cytokine cytokine|amod|END_ENTITY	Ciliary_neurotrophic_factor , a gp130 cytokine , regulates preovulatory surges of luteinizing hormone and prolactin in the rat .
8227315	0	Ciliary_neurotrophic_factor	0,27	low-affinity_nerve_growth_factor_receptor	44,85	Ciliary neurotrophic factor	low-affinity nerve growth factor receptor	25707(Tax:10116)	24596(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- promotes low-affinity_nerve_growth_factor_receptor and CD4 expression by rat CNS microglia .
7780034	0	Ciliary_neurotrophic_factor	0,27	serum_amyloid_A	43,58	Ciliary neurotrophic factor	serum amyloid A	12803(Tax:10090)	111345(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- induces serum_amyloid_A , hypoglycaemia and anorexia , and potentiates IL-1 induced corticosterone and IL-6 production in mice .
8529123	0	Ciliary_neurotrophic_factor	0,27	tumor_necrosis_factor	58,79	Ciliary neurotrophic factor	tumor necrosis factor	12803(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Ciliary_neurotrophic_factor inhibits brain and peripheral tumor_necrosis_factor production and , when coadministered with its soluble receptor , protects mice from lipopolysaccharide toxicity .
26772997	0	Cindr	20,25	JNK	36,39	Cindr	JNK	43654(Tax:7227)	44801(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The adaptor protein Cindr regulates JNK activity to maintain epithelial sheet integrity .
20451383	0	Cindr	0,5	anillin	21,28	Cindr	anillin	43654(Tax:7227)	35696(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cindr interacts with anillin to control cytokinesis in Drosophila_melanogaster .
16723500	0	Cingulin	0,8	RhoA	88,92	Cingulin	RhoA	483198(Tax:9615)	403954(Tax:9615)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA .
16723500	0	Cingulin	0,8	claudin-2	19,28	Cingulin	claudin-2	483198(Tax:9615)	403649(Tax:9615)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA .
7664278	0	Cip-1	184,189	SDI-1	178,183	Cip-1	SDI-1	1026	1026	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Ultraviolet B light induces G1_arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1 / SDI-1 / Cip-1 protein .
11123420	0	Cip1	52,56	cyclin_D1	24,33	Cip1	cyclin D1	114851(Tax:10116)	58919(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of cyclin_D1 , cyclin_E and p21 -LRB- Cip1 -RRB- associated with decreased expression of p27 -LRB- Kip1 -RRB- in chemically induced rat mammary carcinogenesis .
11751903	0	Cip1	4,8	cyclin_D1	19,28	Cip1	cyclin D1	1026	595	Gene	Gene	p21|appos|START_ENTITY Promotes|nsubj|p21 Promotes|dobj|accumulation accumulation|amod|END_ENTITY	p21 -LRB- Cip1 -RRB- Promotes cyclin_D1 nuclear accumulation via direct inhibition of nuclear export .
11369699	0	Cip1	87,91	p21	83,86	Cip1	p21	114851(Tax:10116)	24525(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21 -LRB- Cip1 -RRB- gene into the joints .
11704859	0	Cip1	24,28	p21	20,23	Cip1	p21	1026	644914	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of p16 and p21 -LRB- Cip1 -RRB- expression in tumorigenic human bronchial epithelial cells induced by asbestos .
12773551	0	Cip1	82,86	p21	78,81	Cip1	p21	1026	644914	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21 -LRB- Cip1 -RRB- promoter .
19414386	0	Cip1	35,39	p21	24,27	Cip1	p21	1026	1026	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	G2-phase arrest through p21 -LRB- WAF1 / Cip1 -RRB- induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells .
22117196	0	Cip1	116,120	p21	112,115	Cip1	p21	1026	644914	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21 -LRB- Cip1 -RRB- expression and hampers tumour cell growth in vitro and in vivo .
9593712	0	Cip1	19,23	p21	15,18	Cip1	p21	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	GATA-6 induces p21 -LRB- Cip1 -RRB- expression and G1 cell cycle arrest .
12058028	0	Cip1	70,74	p38_alpha	37,46	Cip1	p38 alpha	1026	1432	Gene	Gene	stabilize|dobj|START_ENTITY stabilize|nsubj|END_ENTITY	The stress-activated protein kinases p38_alpha and JNK1 stabilize p21 -LRB- Cip1 -RRB- by phosphorylation .
11226193	0	Cip4	0,4	COP1	12,16	Cip4	COP1	833693(Tax:3702)	817857(Tax:3702)	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	Cip4 , a new COP1 target , is a nucleus-localized positive regulator of Arabidopsis photomorphogenesis .
9571190	0	Cirp	58,62	cold-inducible_RNA-binding_protein	22,56	Cirp	cold-inducible RNA-binding protein	12696(Tax:10090)	12696(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Diurnal change of the cold-inducible_RNA-binding_protein -LRB- Cirp -RRB- expression in mouse brain .
14560011	0	Cited2	28,34	Bmi1	43,47	Cited2	Bmi1	17684(Tax:10090)	12151(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF .
12149478	0	Cited2	22,28	HIF-1alpha	55,65	Cited2	HIF-1alpha	10370	3091	Gene	Gene	role|nmod|START_ENTITY role|appos|regulator regulator|nmod|END_ENTITY	The essential role of Cited2 , a negative regulator for HIF-1alpha , in heart development and neurulation .
25377420	0	Cited2	14,20	Nanog	29,34	Cited2	Nanog	17684(Tax:10090)	71950(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells .
19035510	0	Cited2	0,6	vascular_endothelial_growth_factor	66,100	Cited2	vascular endothelial growth factor	114490(Tax:10116)	83785(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Cited2 modulates hypoxia-inducible factor-dependent expression of vascular_endothelial_growth_factor in nucleus pulposus cells of the rat intervertebral disc .
23789100	0	Cited3	0,6	Mef2c	17,22	Cited3	Mef2c	100006037(Tax:7955)	17260(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cited3 activates Mef2c to control muscle cell differentiation and survival .
26963853	0	Cks1	45,49	Cdh1	28,32	Cks1	Cdh1	137529	999	Gene	Gene	binding|nmod|START_ENTITY binding|advmod|END_ENTITY	TGF-b activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth .
11231585	0	Cks1	34,38	SCF	55,58	Cks1	SCF	137529	4254	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The cell-cycle regulatory protein Cks1 is required for SCF -LRB- Skp2 -RRB- - mediated ubiquitinylation of p27 .
18056467	0	Cks1	0,4	cdk1	15,19	Cks1	cdk1	137529	983	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Cks1 regulates cdk1 expression : a novel role during mitotic entry in breast_cancer cells .
26963853	0	Cks1	45,49	p27kip1	95,102	Cks1	p27kip1	137529	1027	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	TGF-b activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth .
16033797	0	Cks30A	11,17	Cdk1	33,37	Cks30A	Cdk1	34250(Tax:7227)	34411(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Drosophila Cks30A interacts with Cdk1 to target Cyclin_A for destruction in the female germline .
19339555	0	ClC-4	22,27	transferrin_receptor	31,51	ClC-4	transferrin receptor	12727(Tax:10090)	22042(Tax:10090)	Gene	Gene	START_ENTITY|nmod|function function|compound|END_ENTITY	An essential role for ClC-4 in transferrin_receptor function revealed in studies of fibroblasts derived from Clcn4-null mice .
12904289	0	ClC-5	23,28	Cofilin	0,7	ClC-5	Cofilin	1184	1072	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines .
20810608	0	ClC-5	81,86	HNF1a	25,30	ClC-5	HNF1a	12728(Tax:10090)	21405(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The transcription factor HNF1a regulates expression of chloride-proton exchanger ClC-5 in the renal proximal tubule .
19878925	0	ClC-5	0,5	TGF-beta1	43,52	ClC-5	TGF-beta1	12728(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	ClC-5 regulates dentin development through TGF-beta1 pathway .
16525474	0	ClC-7	0,5	Ostm1	15,20	ClC-7	Ostm1	26373(Tax:10090)	14628(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function .
24159188	0	ClC-7	78,83	Ostm1	84,89	ClC-7	Ostm1	513545(Tax:9913)	518522(Tax:9913)	Gene	Gene	+|dep|START_ENTITY END_ENTITY|dep|+	A missense mutation accelerating the gating of the lysosomal Cl - / H + - exchanger ClC-7 / Ostm1 causes osteopetrosis with gingival_hamartomas in cattle .
10579545	0	Clara_Cell_Protein	61,79	CC16	81,85	Clara Cell Protein	CC16	7356	7356	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Effects of pregnancy and delivery on serum concentrations of Clara_Cell_Protein -LRB- CC16 -RRB- , an endogenous anticytokine : lower serum CC16 is related to postpartum depression There is now some evidence that lower serum concentrations of Clara_Cell_Protein -LRB- CC16 -RRB- are related to stress-induced anxiety , psychoses and major_depression .
19205286	0	Clara_cell_10	11,24	CC10	26,30	Clara cell 10	CC10	7356	7356	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Effects of Clara_cell_10 -LRB- CC10 -RRB- protein on symptoms and signs of allergic_rhinitis .
20553297	0	Clara_cell_10_kDa_protein	55,80	osteopontin	18,29	Clara cell 10 kDa protein	osteopontin	7356	6696	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of osteopontin and its association with Clara_cell_10_kDa_protein in allergic_rhinitis .
26239602	0	Clara_cell_16-kDa_protein	7,32	CC16	34,38	Clara cell 16-kDa protein	CC16	7356	7356	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Serum Clara_cell_16-kDa_protein -LRB- CC16 -RRB- levels and lung_impairment in systemic_sclerosis patients -RSB- .
16251377	0	Clara_cell_protein	79,97	CC16	99,103	Clara cell protein	CC16	7356	7356	Gene	Gene	changes|compound|START_ENTITY changes|appos|END_ENTITY	Glutaraldehyde-induced occupational_asthma : BALF components and BALF and serum Clara_cell_protein -LRB- CC16 -RRB- changes due to specific inhalatory provocation test .
9072037	0	Clara_cell_protein	28,46	CC16	48,52	Clara cell protein	CC16	7356	7356	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Transient increase of serum Clara_cell_protein -LRB- CC16 -RRB- after exposure to smoke .
17716718	0	Clara_cell_protein_10	39,60	CC10	62,66	Clara cell protein 10	CC10	7356	7356	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Infant frequent wheezing correlated to Clara_cell_protein_10 -LRB- CC10 -RRB- polymorphism and concentration , but not allergy sensitization , in a perinatal cohort study .
8071346	0	Clara_cell_secretory_protein	166,194	CCSP	196,200	Clara cell secretory protein	CCSP	7356	7356	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Two members of the HNF-3 family have opposite effects on a lung transcriptional element ; HNF-3_alpha stimulates and HNF-3_beta inhibits activity of region I from the Clara_cell_secretory_protein -LRB- CCSP -RRB- promoter .
12060562	0	Clara_cell_secretory_protein	14,42	EGFR	84,88	Clara cell secretory protein	EGFR	7356	1956	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	IL-13-induced Clara_cell_secretory_protein expression in airway epithelium : role of EGFR signaling pathway .
9612303	0	Clara_cell_secretory_protein	34,62	Interferon-gamma	0,16	Clara cell secretory protein	Interferon-gamma	7356	3458	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interferon-gamma stimulates human Clara_cell_secretory_protein production by human airway epithelial cells .
9761760	0	Clara_cell_secretory_protein	45,73	Tumor_necrosis_factor-alpha	0,27	Clara cell secretory protein	Tumor necrosis factor-alpha	7356	7124	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha stimulates human Clara_cell_secretory_protein production by human airway epithelial cells .
17697625	0	Clara_cell_secretory_protein	80,108	insulin-like_growth_factor-1	30,58	Clara cell secretory protein	insulin-like growth factor-1	7356	3479	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of recombinant human insulin-like_growth_factor-1 on the expression of Clara_cell_secretory_protein in lung of hyperoxia-exposed newborn rats -RSB- .
15190204	0	Claspin	5,12	ATR	0,3	Claspin	ATR	63967	545	Gene	Gene	regulate|nsubj|START_ENTITY regulate|advmod|END_ENTITY	ATR , Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage .
11090622	0	Claspin	0,7	Chk1	56,60	Claspin	Chk1	398192(Tax:8355)	398191(Tax:8355)	Gene	Gene	START_ENTITY|appos|protein protein|acl|required required|nmod|activation activation|nmod|END_ENTITY	Claspin , a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts .
12545175	0	Claspin	34,41	Chk1	75,79	Claspin	Chk1	398192(Tax:8355)	398191(Tax:8355)	Gene	Gene	motifs|nmod|START_ENTITY mediate|nsubj|motifs mediate|dobj|regulated regulated|nmod|END_ENTITY	Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 .
15190204	0	Claspin	5,12	Chk1	53,57	Claspin	Chk1	63967	1111	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	ATR , Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage .
15279790	0	Claspin	0,7	Chk1	24,28	Claspin	Chk1	63967	1111	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Claspin , a regulator of Chk1 in DNA replication stress pathway .
15371427	0	Claspin	0,7	Chk1	77,81	Claspin	Chk1	398192(Tax:8355)	398191(Tax:8355)	Gene	Gene	collaborate|nsubj|START_ENTITY collaborate|nmod|activation activation|nmod|END_ENTITY	Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1 .
16618813	0	Claspin	66,73	Chk1	80,84	Claspin	Chk1	398192(Tax:8355)	398191(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY Xmus101|nmod|phosphorylation requirement|nmod|Xmus101 bound|nsubj|requirement bound|dobj|END_ENTITY	Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling .
16880517	0	Claspin	0,7	Chk1	70,74	Claspin	Chk1	63967	1111	Gene	Gene	operates|nsubj|START_ENTITY operates|xcomp|direct direct|dobj|ATR ATR|acl|signaling signaling|nmod|activation activation|amod|END_ENTITY	Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation .
16885021	0	Claspin	15,22	Chk1	48,52	Claspin	Chk1	63967	1111	Gene	Gene	Destruction|nmod|START_ENTITY restrains|nsubj|Destruction restrains|dobj|activation activation|amod|END_ENTITY	Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress .
16963448	0	Claspin	40,47	Chk1	70,74	Claspin	Chk1	63967	1111	Gene	Gene	motifs|nmod|START_ENTITY phosphorylated|nsubjpass|motifs phosphorylated|nmod|END_ENTITY	Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function .
18331829	0	Claspin	0,7	Chk1	79,83	Claspin	Chk1	428223(Tax:9031)	396486(Tax:9031)	Gene	Gene	phosphorylated|nsubjpass|START_ENTITY phosphorylated|nmod|kinase kinase|amod|distinct distinct|nmod|END_ENTITY	Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1 .
21680713	0	Claspin	51,58	Chk1	112,116	Claspin	Chk1	63967	1111	Gene	Gene	phosphorylation|nmod|START_ENTITY kinase|nmod|phosphorylation kinase|nmod|residues residues|amod|necessary necessary|nmod|activation activation|nmod|END_ENTITY	Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1 .
26082189	0	Claspin	23,30	Chk1	45,49	Claspin	Chk1	63967	1111	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress .
21775519	0	Claspin	21,28	HERC2	0,5	Claspin	HERC2	63967	8924	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression .
16618813	0	Claspin	66,73	Xmus101	23,30	Claspin	Xmus101	398192(Tax:8355)	398573(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling .
15247301	0	Class_II_major_histocompatibility_complex_transactivator	0,56	matrix_metalloproteinase-9	74,100	Class II major histocompatibility complex transactivator	matrix metalloproteinase-9	4261	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Class_II_major_histocompatibility_complex_transactivator -LRB- CIITA -RRB- inhibits matrix_metalloproteinase-9 gene expression .
16343815	0	Clast4	0,6	eIF4E-Transporter	38,55	Clast4	eIF4E-Transporter	74203(Tax:10090)	56478	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Clast4 , the murine homologue of human eIF4E-Transporter , is highly expressed in developing oocytes and post-translationally modified at meiotic maturation .
20566684	0	Clathrin_heavy_chain	0,20	TACC3	30,35	Clathrin heavy chain	TACC3	1213	10460	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Clathrin_heavy_chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability .
25860340	0	Clathrin_heavy_chain	0,20	estrogen_receptor_a	36,55	Clathrin heavy chain	estrogen receptor a	1213	2099	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Clathrin_heavy_chain interacts with estrogen_receptor_a and modulates 17b-estradiol signaling .
26157141	0	Claudin-1	46,55	Heat_Shock_Factor_1	104,123	Claudin-1	Heat Shock Factor 1	9076	3297	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Activation Activation|compound|END_ENTITY	Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat_Shock_Factor_1 Activation , Leading to Hepatoma Cell Invasiveness .
25001509	0	Claudin-1	0,9	miR-375	31,38	Claudin-1	miR-375	9076	494324	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Claudin-1 is a novel target of miR-375 in non-small-cell_lung_cancer .
22373575	0	Claudin-14	0,10	CaSR	61,65	Claudin-14	CaSR	23562	846	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Claudin-14 regulates renal Ca ____ transport in response to CaSR signalling via a novel microRNA pathway .
26061016	0	Claudin-2	20,29	miR-16	79,85	Claudin-2	miR-16	9075	51573	Gene	Gene	START_ENTITY|nmod|Up-Regulation Up-Regulation|nmod|END_ENTITY	Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung_Adenocarcinoma A549 Cells .
22559840	0	Claudin-5	0,9	N-WASP	65,71	Claudin-5	N-WASP	7122	8976	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Claudin-5 is involved in breast_cancer cell motility through the N-WASP and ROCK signalling pathways .
25667483	0	Claudin-5	0,9	TATI	38,42	Claudin-5	TATI	7122	6690	Gene	Gene	Associated|nsubj|START_ENTITY Associated|nmod|END_ENTITY	Claudin-5 Is Associated with Elevated TATI and CA125 Levels in Mucinous Ovarian Borderline Tumors .
21847390	0	Claudin-6	49,58	Estrogen_Receptor-a	8,27	Claudin-6	Estrogen Receptor-a	9074	2099	Gene	Gene	Expression|compound|START_ENTITY Regulation|nmod|Expression Role|nmod|Regulation Role|nmod|END_ENTITY	Role of Estrogen_Receptor-a in the Regulation of Claudin-6 Expression in Breast_Cancer Cells .
26216285	0	Claudin-7	16,25	HNF4a	0,5	claudin-7	HNF4a	1366	3172	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	HNF4a Regulates Claudin-7 Protein Expression during Intestinal Epithelial Differentiation .
12839333	0	Claudin-8	0,9	multi-PDZ_domain_protein_1	25,51	Claudin-8	multi-PDZ domain protein 1	478401(Tax:9615)	8777	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Claudin-8 interacts with multi-PDZ_domain_protein_1 -LRB- MUPP1 -RRB- and reduces paracellular conductance in epithelial cells .
25562426	0	Claudin_1	64,73	TNF-a	50,55	Claudin 1	TNF-a	9076	7124	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	PKC - iPLA2-PGE2-PPARy signaling cascade mediates TNF-a induced Claudin_1 expression in human lung_carcinoma cells .
7906711	0	Claustrin	0,9	MAP1B	91,96	Claustrin	MAP1B	396174(Tax:9031)	396174(Tax:9031)	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	Claustrin , an antiadhesive neural keratan sulfate proteoglycan , is structurally related to MAP1B .
12865300	0	Clb	80,83	CLB	117,120	Clb	CLB	171425	171425	Gene	Gene	activity|compound|START_ENTITY domain|nmod|activity Ndd1p|nmod|domain Recruitment|nmod|Ndd1p Recruitment|dep|mechanism mechanism|nmod|activation activation|compound|END_ENTITY	Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity : a mechanism for CLB cluster gene activation .
12865300	0	Clb	80,83	Fkh2p	65,70	Clb	Fkh2p	171425	2290	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity : a mechanism for CLB cluster gene activation .
7622567	0	Clb1	15,19	NAP1	0,4	Clb1	NAP1	853002(Tax:4932)	853922(Tax:4932)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast .
8522159	0	Clc2	25,29	Chloride_channel_2	0,18	Clc2	Chloride channel 2	12724(Tax:10090)	12724(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chloride_channel_2 gene -LRB- Clc2 -RRB- maps to chromosome 16 of the mouse , extending a region of conserved synteny with human chromosome 3q .
25957769	0	Clec4g	0,6	BACE1	32,37	Clec4g	BACE1	75863(Tax:10090)	23821(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Clec4g -LRB- LSECtin -RRB- interacts with BACE1 and suppresses Ab generation .
19139280	0	ClipR-59	0,8	Akt	24,27	ClipR-59	Akt	25999	207	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization .
24001771	0	ClipR-59	21,29	ClipR-59	44,52	ClipR-59	ClipR-59	25999	25999	Gene	Gene	association|amod|START_ENTITY association|compound|END_ENTITY	DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane .
24001771	0	ClipR-59	44,52	ClipR-59	21,29	ClipR-59	ClipR-59	25999	25999	Gene	Gene	association|compound|START_ENTITY association|amod|END_ENTITY	DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane .
25572395	0	ClipR-59	0,8	Elmo2	24,29	ClipR-59	Elmo2	76686(Tax:10090)	140579(Tax:10090)	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	ClipR-59 Interacts with Elmo2 and Modulates Myoblast Fusion .
12169693	0	Clk4	76,80	clasp	30,35	Clk4	clasp	12750(Tax:10090)	53609(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk .
9819356	0	Cln2	53,57	Grr1	25,29	Cln2	Grr1	855819(Tax:4932)	853552(Tax:4932)	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	An essential function of Grr1 for the degradation of Cln2 is to act as a binding core that links Cln2 to Skp1 .
20850431	0	Cln3	86,90	CLN3	23,27	Cln3	CLN3	12752(Tax:10090)	12752(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY motility|nmod|cells interaction|nmod|motility interaction|nmod|END_ENTITY	A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3 -LRB- - / - -RRB- cells .
20850431	0	Cln3	86,90	myosin-IIB	43,53	Cln3	myosin-IIB	12752(Tax:10090)	77579(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY motility|nmod|cells interaction|nmod|motility interaction|nmod|END_ENTITY	A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3 -LRB- - / - -RRB- cells .
10191121	0	Cln3p	62,67	Btn1p	28,33	Cln3p	Btn1p	1201	853387(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Studies of pH regulation by Btn1p , the yeast homolog of human Cln3p .
10652231	0	Clock	48,53	BMAL1	23,28	Clock	BMAL1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY altered|nmod|mice altered|nsubjpass|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Rhythmic expression of BMAL1 mRNA is altered in Clock mutant mice : differential regulation in the suprachiasmatic nucleus and peripheral tissues .
23580255	0	Clock	36,41	BMAL1	101,106	Clock	BMAL1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	mutant|compound|START_ENTITY suppressor|nmod|mutant Usf1|appos|suppressor reveals|nsubj|Usf1 reveals|dobj|nature nature|dep|complex complex|nummod|END_ENTITY	Usf1 , a suppressor of the circadian Clock mutant , reveals the nature of the DNA-binding of the CLOCK : BMAL1 complex in mice .
26562092	0	Clock	88,93	BMAL1	31,36	Clock	BMAL1	9575	406	Gene	Gene	Control|dobj|START_ENTITY CK2-Mediated|xcomp|Control CK2-Mediated|dobj|Phosphorylation Phosphorylation|compound|END_ENTITY	CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock .
9735336	0	Clock	68,73	BMAL1	25,30	Clock	BMAL1	9575	406	Gene	Gene	partner|nmod|START_ENTITY oscillation|appos|partner oscillation|nmod|END_ENTITY	Circadian oscillation of BMAL1 , a partner of a mammalian clock gene Clock , in rat suprachiasmatic nucleus .
9875535	0	Clock	97,102	BMAL1	45,50	Clock	BMAL1	9575	406	Gene	Gene	partner|nmod|START_ENTITY rhythm|appos|partner rhythm|nmod|expression expression|compound|END_ENTITY	Circadian rhythm and light responsiveness of BMAL1 expression , a partner of mammalian clock gene Clock , in the suprachiasmatic nucleus of rats .
25855785	0	Clock	10,15	CRY2	21,25	Clock	CRY2	9575	1408	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal_Cancer .
15254898	0	Clock	68,73	Pax6	0,4	Clock	Pax6	9575	5080	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Pax6 is a direct , positively regulated target of the circadian gene Clock .
24916389	0	Clock	30,35	TWIN-OF-EYELESS	11,26	Clock	TWIN-OF-EYELESS	38872(Tax:7227)	43833(Tax:7227)	Gene	Gene	Expression|compound|START_ENTITY Effects|nmod|Expression Effects|nmod|END_ENTITY	Effects of TWIN-OF-EYELESS on Clock Gene Expression and Central-Pacemaker Neuron Development in Drosophila .
12387815	0	Clock	164,169	mPer2	126,131	Clock	mPer2	12753(Tax:10090)	18627(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY heart|nmod|mice mRNAs|nmod|heart mRNAs|compound|END_ENTITY	Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding : entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl : ICR background .
20472413	0	Clock	0,5	mPer2	11,16	Clock	mPer2	12753(Tax:10090)	18627(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY functions|amod|END_ENTITY	Clock gene mPer2 functions in diurnal variation of acetaminophen induced hepatotoxicity in mice .
19414365	0	Clock	0,5	period2	17,24	Clock	period2	12753(Tax:10090)	18627(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY mouse|dep|overexpression overexpression|amod|END_ENTITY	Clock gene mouse period2 overexpression inhibits growth of human pancreatic_cancer cells and has synergistic effect with cisplatin .
24843029	0	ClpB	62,66	Hsp70	97,102	ClpB	Hsp70	81570	3308	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein_disaggregation .
16765060	0	ClpB	51,55	Hsp78	26,31	ClpB	Hsp78	81570	81570	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Structure and function of Hsp78 , the mitochondrial ClpB homolog .
10634913	0	ClpP	23,27	cytochrome_b	66,78	ClpP	cytochrome b	2717015(Tax:3055)	801484(Tax:3055)	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	Evidence for a role of ClpP in the degradation of the chloroplast cytochrome_b -LRB- 6 -RRB- f complex .
17577058	0	ClpX	106,110	clpX	20,24	ClpX	clpX	10845	10845	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|gene gene|compound|END_ENTITY	Distribution of the clpX gene in Brachyspira species and reactivity of recombinant Brachyspira_pilosicoli ClpX with sera from mice and humans .
22848862	0	Clusterin	53,62	Apolipoprotein_J	36,52	Clusterin	Apolipoprotein J	1191	1191	Gene	Gene	Expression|compound|START_ENTITY Study|dep|Expression Study|nmod|END_ENTITY	Retrospective Case-Control Study of Apolipoprotein_J / Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis .
22197644	0	Clusterin	0,9	Bcl-xL	27,33	Clusterin	Bcl-xL	1191	598	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Clusterin interaction with Bcl-xL is associated with seizure-induced neuronal_death .
20813109	0	Clusterin	0,9	CXCR4	18,23	Clusterin	CXCR4	1191	7852	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Clusterin induces CXCR4 expression and migration of cardiac progenitor cells .
20729304	0	Clusterin	0,9	IL-2	26,30	Clusterin	IL-2	12759(Tax:10090)	16183(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Clusterin synergizes with IL-2 for the expansion and IFN-y production of natural killer cells .
16038898	0	Clusterin	0,9	SCLIP	25,30	Clusterin	SCLIP	24854(Tax:10116)	29246(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Clusterin interacts with SCLIP -LRB- SCG10-like_protein -RRB- and promotes neurite outgrowth of PC12 cells .
14618611	0	Clusterin	0,9	SGP-2	11,16	Clusterin	SGP-2	1191	1191	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clusterin -LRB- SGP-2 , ApoJ -RRB- expression is downregulated in low - and high-grade human prostate_cancer .
8963451	0	Clusterin	0,9	SGP-2	11,16	Clusterin	SGP-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Clusterin -LRB- SGP-2 -RRB- induction in rat astroglial cells exposed to prion protein fragment 106-126 .
9815554	0	Clusterin	31,40	SGP-2	24,29	Clusterin	SGP-2	1191	1191	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Intracellular levels of SGP-2 -LRB- Clusterin -RRB- correlate with tumor grade in prostate_cancer .
23515283	0	Clusterin	0,9	SREBP-1c	28,36	Clusterin	SREBP-1c	12759(Tax:10090)	20787(Tax:10090)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Clusterin decreases hepatic SREBP-1c expression and lipid accumulation .
23805218	0	Clusterin	43,52	Selenoprotein_R	22,37	Clusterin	Selenoprotein R	1191	51734	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Direct Interaction of Selenoprotein_R with Clusterin and Its Possible Role in Alzheimer 's _ Disease .
22575505	0	Clusterin	0,9	TNF-a	35,40	Clusterin	TNF-a	1191	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Clusterin induces the secretion of TNF-a and the chemotactic migration of macrophages .
24381170	0	Clusterin	0,9	apolipoprotein_E_receptor_2	26,53	Clusterin	apolipoprotein E receptor 2	1191	7804	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Clusterin is a ligand for apolipoprotein_E_receptor_2 -LRB- ApoER2 -RRB- and very_low_density_lipoprotein_receptor -LRB- VLDLR -RRB- and signals via the Reelin-signaling pathway .
9878186	0	Clusterin	0,9	apolipoprotein_J	11,27	Clusterin	apolipoprotein J	1191	1191	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Clusterin -LRB- apolipoprotein_J -RRB- protein levels are increased in hippocampus and in frontal cortex in Alzheimer 's _ disease .
24327270	0	Clusterin	0,9	microRNA-21	39,50	Clusterin	microRNA-21	1191	406991	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Clusterin is a gene-specific target of microRNA-21 in head_and_neck_squamous_cell_carcinoma .
16144839	0	Cnap1	44,49	Melk	69,73	Cnap1	Melk	68298(Tax:10090)	17279(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin _ D3 .
15173200	0	Cne1p	60,65	calnexin	69,77	Cne1p	calnexin	851241(Tax:4932)	851241(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Expression and characterization of Saccharomyces_cerevisiae Cne1p , a calnexin homologue .
15107851	0	Cnot7	47,52	retinoid_X_receptor_beta	69,93	Cnot7	retinoid X receptor beta	18983(Tax:10090)	20182(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Oligo-astheno-teratozoospermia in mice lacking Cnot7 , a regulator of retinoid_X_receptor_beta .
26647347	0	Cntnap2	14,21	Caspr2	23,29	Cntnap2	Caspr2	66797(Tax:10090)	66797(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Cntnap2 -LRB- Caspr2 -RRB- in multiple levels of sensory systems .
2775217	0	Co2	9,12	carboxypeptidase_H	94,112	Co2	carboxypeptidase H	717	1363	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	Enhanced Co2 + activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase_H -LRB- enkephalin_convertase -RRB- .
21736557	0	CoAA	26,30	PEA3	41,45	CoAA	PEA3	10432	2118	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The coactivator_activator CoAA regulates PEA3 group member transcriptional activity .
25447311	0	Coagulation_factor_VII	0,22	androgen_receptor	39,56	Coagulation factor VII	androgen receptor	2155	367	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Coagulation_factor_VII is regulated by androgen_receptor in breast_cancer .
26266486	0	Cocaine_and_Amphetamine_Regulated_Transcript	14,58	CART	60,64	Cocaine and Amphetamine Regulated Transcript	CART	397252(Tax:9823)	397252(Tax:9823)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Cocaine_and_Amphetamine_Regulated_Transcript -LRB- CART -RRB- in the Porcine Intramural Neurons of Stomach in the Course of Experimentally Induced Diabetes_Mellitus .
14657014	0	Cochlin	0,7	leukemia_inhibitory_factor	91,117	Cochlin	leukemia inhibitory factor	12810(Tax:10090)	16878(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cochlin , a secreted von_Willebrand factor type a domain-containing factor , is regulated by leukemia_inhibitory_factor in the uterus at the time of embryo implantation .
21364188	0	Codanin-1	0,9	congenital_dyserythropoietic_anemia_type_1	23,65	Codanin-1	congenital dyserythropoietic anemia type 1	146059	146059	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Codanin-1 mutations in congenital_dyserythropoietic_anemia_type_1 affect HP1 -LCB- alpha -RCB- localization in erythroblasts .
22450169	0	Cofilin	0,7	14-3-3	30,36	Cofilin	14-3-3	1072	10971	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 -LRB- Hsp20 -RRB- .
12904289	0	Cofilin	0,7	ClC-5	23,28	Cofilin	ClC-5	1072	1184	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines .
25549357	0	Cofilin	15,22	EZH2	0,4	Cofilin	EZH2	1072	2146	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	EZH2 Regulates Cofilin Activity and Colon_Cancer Cell Migration by Targeting ITGA2 Gene .
11418599	0	Cofilin	0,7	testicular_protein_kinase_2	63,90	Cofilin	testicular protein kinase 2	1072	10420	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cofilin phosphorylation and actin reorganization activities of testicular_protein_kinase_2 and its predominant expression in testicular Sertoli cells .
10806077	0	Coil	62,66	coilin	49,55	Coil	coilin	12812(Tax:10090)	12812(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and characterization of the murine p80 coilin gene , Coil .
10806077	0	Coil	62,66	p80	45,48	Coil	p80	12812(Tax:10090)	12812(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and characterization of the murine p80 coilin gene , Coil .
25205658	0	Coiled-Coil_Domain_Containing_80	4,36	gadd45b2	61,69	Coiled-Coil Domain Containing 80	gadd45b2	368419(Tax:7955)	406304(Tax:7955)	Gene	Gene	START_ENTITY|dep|Expression Expression|compound|END_ENTITY	The Coiled-Coil_Domain_Containing_80 -LRB- ccdc80 -RRB- Gene Regulates gadd45b2 Expression in the Developing Somites of Zebrafish as a New Player of the Hedgehog Pathway .
15598659	0	Col1a1	0,6	C/EBPbeta	104,113	Col1a1	C/EBPbeta	12842(Tax:10090)	12608(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|isoform isoform|compound|END_ENTITY	Col1a1 promoter-targeted expression of p20 CCAAT_enhancer-binding_protein beta -LRB- C/EBPbeta -RRB- , a truncated C/EBPbeta isoform , causes osteopenia in transgenic_mice .
15598659	0	Col1a1	0,6	C/EBPbeta	80,89	Col1a1	C/EBPbeta	12842(Tax:10090)	12608(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Col1a1 promoter-targeted expression of p20 CCAAT_enhancer-binding_protein beta -LRB- C/EBPbeta -RRB- , a truncated C/EBPbeta isoform , causes osteopenia in transgenic_mice .
23159876	0	Col1a1	16,22	Osterix	0,7	Col1a1	Osterix	12842(Tax:10090)	170574(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions .
23159876	0	Col1a1	16,22	Sp1	58,61	Col1a1	Sp1	12842(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|regions regions|amod|binding binding|nmod|sites sites|amod|END_ENTITY	Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions .
15456958	0	Col2a1	149,155	alphaA-crystallin-binding_protein_1	32,67	Col2a1	alphaA-crystallin-binding protein 1	12824(Tax:10090)	110521(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY transcription|nmod|promoter transcription|nsubj|stimulates stimulates|amod|Oligonucleotide Oligonucleotide|dep|mimicking mimicking|dobj|site site|amod|END_ENTITY	Oligonucleotide decoy mimicking alphaA-crystallin-binding_protein_1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell .
15456958	0	Col2a1	90,96	alphaA-crystallin-binding_protein_1	32,67	Col2a1	alphaA-crystallin-binding protein 1	12824(Tax:10090)	110521(Tax:10090)	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Oligonucleotide decoy mimicking alphaA-crystallin-binding_protein_1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell .
17525254	0	Col4a2	50,56	SRY-related_HMG_box_9	0,21	Col4a2	SRY-related HMG box 9	12827(Tax:10090)	20682(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SRY-related_HMG_box_9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells .
17488278	0	ColQ	99,103	Calcitonin_gene-related_peptide	0,31	ColQ	Calcitonin gene-related peptide	8292	796	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Calcitonin_gene-related_peptide induces the expression of acetylcholinesterase-associated collagen ColQ in muscle : a distinction in driving two different promoters between fast - and slow-twitch muscle fibers .
18718538	0	ColQ	112,116	Myocyte_enhancer_factor_2	0,25	ColQ	Myocyte enhancer factor 2	8292	4205	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Myocyte_enhancer_factor_2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes .
23159887	0	ColQ	184,188	acetylcholinesterase	193,213	ColQ	acetylcholinesterase	29755(Tax:10116)	83817(Tax:10116)	Gene	Gene	subunit|appos|START_ENTITY subunit|nmod|END_ENTITY	Expression of cAMP-responsive_element_binding_proteins -LRB- CREBs -RRB- in fast - and slow-twitch muscles : a signaling pathway to account for the synaptic expression of collagen-tailed subunit -LRB- ColQ -RRB- of acetylcholinesterase at the rat neuromuscular junction .
25934796	0	Cold-Inducible_RNA-Binding_Protein	14,48	CIRP	50,54	Cold-Inducible RNA-Binding Protein	CIRP	1153	1153	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Cold-Inducible_RNA-Binding_Protein -LRB- CIRP -RRB- in Pituitary_Adenoma and its Relationships with Tumor Recurrence .
19398494	0	Cold-inducible_RNA_binding_protein	0,34	CIRP	36,40	Cold-inducible RNA binding protein	CIRP	12696(Tax:10090)	12696(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cold-inducible_RNA_binding_protein -LRB- CIRP -RRB- expression is modulated by alternative mRNAs .
25502582	0	Collagen	29,37	COL1A1	39,45	Collagen	COL1A1	1277	1277	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	The Polymorphism of Type 1 Collagen -LRB- COL1A1 -RRB- Gene does not Correlate with an Increased Risk of Foot Ulcers in Patients with Diabetes_Mellitus .
19785951	0	Collagen_I_and_transforming_growth_factor_beta_1	44,92	IFN_alpha	12,21	Collagen I and transforming growth factor beta 1	IFN alpha	7040	3439	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of IFN_alpha on the expressions of Collagen_I_and_transforming_growth_factor_beta_1 in hepatic stellate cell activated by PDGF-BB -RSB- .
26664254	0	Collagen_Triple_Helix_Repeat_Containing-1	0,41	CTHRC1	43,49	Collagen Triple Helix Repeat Containing-1	CTHRC1	115908	115908	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Collagen_Triple_Helix_Repeat_Containing-1 -LRB- CTHRC1 -RRB- Expression in Oral_Squamous_Cell_Carcinoma -LRB- OSCC -RRB- : Prognostic Value and Clinico-Pathological Implications .
23658133	0	Collagen_triple_helix_repeat_containing-1	0,41	CTHRC1	43,49	Collagen triple helix repeat containing-1	CTHRC1	115908	115908	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Collagen_triple_helix_repeat_containing-1 -LRB- CTHRC1 -RRB- expression in invasive_ductal_carcinoma of the breast : the impact on prognosis and correlation to clinicopathologic features .
9727011	0	Collagenase_2	0,13	MMP-8	15,20	Collagenase 2	MMP-8	17394(Tax:10090)	17394(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Collagenase_2 -LRB- MMP-8 -RRB- expression in murine tissue-remodeling processes .
25040932	0	Collapsin_response-mediator_protein_5	0,37	CRMP5	39,44	Collapsin response-mediator protein 5	CRMP5	65208(Tax:10116)	65208(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Collapsin_response-mediator_protein_5 -LRB- CRMP5 -RRB- phosphorylation at threonine 516 regulates neurite outgrowth inhibition .
18598844	0	Collapsin_response_mediator_protein-4	0,37	CRMP-4	39,45	Collapsin response mediator protein-4	CRMP-4	1809	1809	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Collapsin_response_mediator_protein-4 -LRB- CRMP-4 -RRB- expression in posthaching development of song control nuclei in Bengalese finches .
17182786	0	Collapsin_response_mediator_protein_1	0,37	reelin	47,53	Collapsin response mediator protein 1	reelin	12933(Tax:10090)	19699(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Collapsin_response_mediator_protein_1 mediates reelin signaling in cortical neuronal migration .
25898924	0	Collybistin	0,11	mTORC1	31,37	Collybistin	mTORC1	23229	382056(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Collybistin binds and inhibits mTORC1 signaling : a potential novel mechanism contributing to intellectual_disability and autism .
18178156	0	Complement_3	0,12	KLF5	27,31	Complement 3	KLF5	24232(Tax:10116)	84410(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|gene gene|compound|END_ENTITY	Complement_3 activates the KLF5 gene in rat vascular smooth muscle cells .
9403532	0	Complement_C3	0,13	interleukin_1beta	78,95	Complement C3	interleukin 1beta	718	3553	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Complement_C3 production in human intestinal epithelial cells is regulated by interleukin_1beta and tumor_necrosis_factor_alpha .
26718342	0	Complement_Component_3	0,22	TWIST1	39,45	Complement Component 3	TWIST1	12266(Tax:10090)	22160(Tax:10090)	Gene	Gene	Regulated|nsubjpass|START_ENTITY Regulated|nmod|END_ENTITY	Complement_Component_3 Is Regulated by TWIST1 and Mediates Epithelial-Mesenchymal Transition .
21163535	0	Complement_Factor_B	30,49	CFB	56,59	Complement Factor B	CFB	101115072	101115072	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the sheep Complement_Factor_B gene -LRB- CFB -RRB- .
25687755	0	Complement_Receptor_Ig	46,68	Protein_Kinase	0,14	Complement Receptor Ig	Protein Kinase	11326	1022	Gene	Gene	Expression|nmod|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	Protein_Kinase Ca Regulates the Expression of Complement_Receptor_Ig in Human Monocyte-Derived Macrophages .
24760264	0	Complement_factor_3	0,19	insulin	39,46	Complement factor 3	insulin	718	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Complement_factor_3 is associated with insulin resistance and with incident type 2 diabetes over a 7-year follow-up period : the CODAM Study .
22918646	0	Complement_factor_H	0,19	Cd59a	79,84	Complement factor H	Cd59a	12628(Tax:10090)	12509(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Complement_factor_H deficiency results in decreased neuroretinal expression of Cd59a in aged mice .
9324355	0	Complement_receptor_type_1	0,26	C1q	57,60	Complement receptor type 1	C1q	1378	712	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- is a receptor for C1q .
1839374	0	Complement_receptor_type_1	0,26	CR1	28,31	Complement receptor type 1	CR1	1378	1378	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression on peripheral T lymphocytes : both CD4 - and CD8-positive cells express CR1 .
22084725	0	Component_5	30,41	C5	43,45	Component 5	C5	727	727	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	High Expression of Complement Component_5 -LRB- C5 -RRB- at Tumor Site Associates with Superior Survival in Ewing 's _ Sarcoma Family of Tumour Patients .
17680991	0	Cone_arrestin	0,13	JNK3	25,29	Cone arrestin	JNK3	407	5602	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Cone_arrestin binding to JNK3 and Mdm2 : conformational preference and localization of interaction sites .
22072793	0	Connecdenn_3	0,12	DENND1C	13,20	Connecdenn 3	DENND1C	79958	79958	Gene	Gene	START_ENTITY|parataxis|binds binds|nsubj|END_ENTITY	Connecdenn_3 / DENND1C binds actin linking Rab35 activation to the actin cytoskeleton .
26425899	0	Connective_Tissue_Growth_Factor	24,55	CTGF	57,61	Connective Tissue Growth Factor	CTGF	1490	1490	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Increased Expression of Connective_Tissue_Growth_Factor -LRB- CTGF -RRB- in Multiple Organs After Exposure of Non-Human Primates -LRB- NHP -RRB- to Lethal Doses of Radiation .
26599235	0	Connective_Tissue_Growth_Factor	14,45	CTGF	47,51	Connective Tissue Growth Factor	CTGF	1490	1490	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Alteration of Connective_Tissue_Growth_Factor -LRB- CTGF -RRB- Expression in Orbital Fibroblasts from Patients with Graves ' _ Ophthalmopathy .
25955392	0	Connective_Tissue_Growth_Factor	20,51	TGF-b1	0,6	Connective Tissue Growth Factor	TGF-b1	1490	7040	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b1 Up-Regulates Connective_Tissue_Growth_Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways .
26371948	0	Connective_Tissue_Growth_Factor	69,100	mTOR	0,4	Connective Tissue Growth Factor	mTOR	1490	21977(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dobj|Expression	mTOR Complexes Repress Hypertrophic Agonist-Stimulated Expression of Connective_Tissue_Growth_Factor in Adult Cardiac Muscle Cells .
26945106	0	Connective_Tissue_Growth_Factor	23,54	miR-133b	0,8	Connective Tissue Growth Factor	miR-133b	64032(Tax:10116)	100314078(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|amod|END_ENTITY	miR-133b Regulation of Connective_Tissue_Growth_Factor : A Novel Mechanism in Liver Pathology .
20971063	0	Connective_tissue_growth_factor	0,31	ADAM28	50,56	Connective tissue growth factor	ADAM28	1490	10863	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Connective_tissue_growth_factor is a substrate of ADAM28 .
16790529	0	Connective_tissue_growth_factor	0,31	CCN2	32,36	Connective tissue growth factor	CCN2	1490	1490	Gene	Gene	START_ENTITY|parataxis|stimulates stimulates|nsubj|END_ENTITY	Connective_tissue_growth_factor / CCN2 stimulates actin disassembly through Akt/protein _ kinase_B-mediated phosphorylation and cytoplasmic translocation of p27 -LRB- Kip-1 -RRB- .
15319369	0	Connective_tissue_growth_factor	0,31	CTGF	33,37	Connective tissue growth factor	CTGF	1490	1490	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Connective_tissue_growth_factor -LSB- CTGF -RSB- / CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization .
16186174	0	Connective_tissue_growth_factor	0,31	CTGF	33,37	Connective tissue growth factor	CTGF	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Connective_tissue_growth_factor -LRB- CTGF -RRB- expression in the brain is a downstream effector of insulin resistance - associated promotion of Alzheimer 's _ disease beta-amyloid_neuropathology .
19955828	0	Connective_tissue_growth_factor	0,31	CTGF	33,37	Connective tissue growth factor	CTGF	1490	1490	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Connective_tissue_growth_factor - -LRB- CTGF , CCN2 -RRB- -- a marker , mediator and therapeutic target for renal_fibrosis .
23950936	0	Connective_tissue_growth_factor	0,31	CTGF	33,37	Connective tissue growth factor	CTGF	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Connective_tissue_growth_factor -LRB- CTGF -RRB- expression modulates response to high glucose .
20585662	0	Connective_tissue_growth_factor	0,31	RhoA	49,53	Connective tissue growth factor	RhoA	14219(Tax:10090)	11848(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Connective_tissue_growth_factor in regulation of RhoA mediated cytoskeletal tension associated osteogenesis of mouse adipose-derived stromal cells .
19309720	0	Connective_tissue_growth_factor	0,31	Smad2	37,42	Connective tissue growth factor	Smad2	64032(Tax:10116)	29357(Tax:10116)	Gene	Gene	amplifier|nsubj|START_ENTITY amplifier|amod|END_ENTITY	Connective_tissue_growth_factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes -- but without modulating bone_morphogenetic_protein_7 signaling .
15123357	0	Connective_tissue_growth_factor	0,31	c-fos	40,45	Connective tissue growth factor	c-fos	64032(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	Connective_tissue_growth_factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells .
19369735	0	Connective_tissue_growth_factor	0,31	ctgf	33,37	Connective tissue growth factor	ctgf	1490	1490	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Connective_tissue_growth_factor -LRB- ctgf -RRB- expression in the tenosynovium of patients with carpal_tunnel_syndrome - biomed 2009 .
23929714	0	Connective_tissue_growth_factor	0,31	epidermal_growth_factor_receptor	51,83	Connective tissue growth factor	epidermal growth factor receptor	14219(Tax:10090)	13649(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Connective_tissue_growth_factor is a new ligand of epidermal_growth_factor_receptor .
15298857	0	Connective_tissue_growth_factor	0,31	transforming_growth_factor-beta	60,91	Connective tissue growth factor	transforming growth factor-beta	1490	7040	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Connective_tissue_growth_factor expression and induction by transforming_growth_factor-beta is abrogated by simvastatin via a Rho signaling mechanism .
20438517	0	Connective_tissue_growth_factor	0,31	transforming_growth_factor-beta1	140,172	Connective tissue growth factor	transforming growth factor-beta1	1490	7040	Gene	Gene	knockdown|compound|START_ENTITY attenuated|nsubj|knockdown attenuated|dobj|production production|acl|induced induced|nmod|cells cells|amod|END_ENTITY	Connective_tissue_growth_factor knockdown attenuated matrix protein production and vascular_endothelial_growth_factor expression induced by transforming_growth_factor-beta1 in cultured human peritoneal mesothelial cells .
11744618	0	Connective_tissue_growth_factor	0,31	vascular_endothelial_growth_factor	38,72	Connective tissue growth factor	vascular endothelial growth factor	14219(Tax:10090)	22339(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Connective_tissue_growth_factor binds vascular_endothelial_growth_factor -LRB- VEGF -RRB- and inhibits VEGF-induced angiogenesis .
12605268	0	Connective_tissue_growth_factor	0,31	vascular_endothelial_growth_factor	73,107	Connective tissue growth factor	vascular endothelial growth factor	1490	7422	Gene	Gene	START_ENTITY|dep|presence presence|nmod|END_ENTITY	Connective_tissue_growth_factor in pterygium : simultaneous presence with vascular_endothelial_growth_factor - possible contributing factor to conjunctival scarring .
12820703	0	Connexin-26	61,72	GJB2	55,59	Connexin-26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic laboratory practices related to testing of the GJB2 -LRB- Connexin-26 -RRB- gene in the United States in 1999 and 2000 .
14979964	0	Connexin-26	48,59	GJB2	61,65	Connexin-26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hearing_loss associated with 35delG mutation in Connexin-26 -LRB- GJB2 -RRB- gene : audiogram analysis .
20407643	0	Connexin-26	30,41	GJB2	24,28	Connexin-26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Absence of mutations in GJB2 -LRB- Connexin-26 -RRB- gene in an ethnic group of southwest Iran .
22369226	0	Connexin-26	6,17	GJB2	0,4	Connexin-26	GJB2	2706	2706	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	GJB2 -LRB- Connexin-26 -RRB- mutations are not frequent among hearing_impaired patients in east Greenland .
12064592	0	Connexin-43	0,11	ZO-1_and_alpha	30,44	Connexin-43	ZO-1 and alpha	2697	7082	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Connexin-43 interactions with ZO-1_and_alpha - and beta-tubulin .
12522692	0	Connexin26	0,10	GJB2	18,22	Connexin26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Connexin26 gene -LRB- GJB2 -RRB- : prevalence of mutations in the Chinese population .
16449318	0	Connexin31	0,10	connexin43	39,49	Connexin31	connexin43	14620(Tax:10090)	14609(Tax:10090)	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	Connexin31 can not functionally replace connexin43 during cardiac morphogenesis in mice .
25237906	0	Connexin32	76,86	ERK1/2	125,131	Connexin32	ERK1/2	2705	5595;5594	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons .
26806558	0	Connexin43	16,26	AMPK	0,4	Connexin43	AMPK	14609(Tax:10090)	78975(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis .
26275398	0	Connexin43	92,102	Peroxisome_Proliferator-Activated_Receptor_Gamma	0,48	Connexin43	Peroxisome Proliferator-Activated Receptor Gamma	24392(Tax:10116)	25664(Tax:10116)	Gene	Gene	Cells|nmod|START_ENTITY Cells|compound|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-b1 / Smads Signaling in a Rat Model of Myocardial_Infarction .
26275398	0	Connexin43	92,102	TGF-b1	125,131	Connexin43	TGF-b1	24392(Tax:10116)	59086(Tax:10116)	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-b1 / Smads Signaling in a Rat Model of Myocardial_Infarction .
23460926	0	Connexin43	0,10	connexin43	46,56	Connexin43	connexin43	100518636	100518636	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Connexin43 hemichannel-mediated regulation of connexin43 .
11557048	0	Connexin45	0,10	ZO-1	29,33	Connexin45	ZO-1	490936(Tax:9615)	403752(Tax:9615)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells .
10079513	0	Connexin45	0,10	alpha_6	12,19	Connexin45	alpha 6	14615(Tax:10090)	14399(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Connexin45 -LRB- alpha_6 -RRB- expression delineates an extended conduction system in the embryonic and mature rodent heart .
15770735	0	Connexin_26	0,11	Bcl-xL	28,34	Connexin 26	Bcl-xL	2706	598	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|expression expression|compound|END_ENTITY	Connexin_26 correlates with Bcl-xL and Bax proteins expression in colorectal_cancer .
26492081	0	Connexin_26	74,85	Caveolin-2	60,70	Connexin 26	Caveolin-2	14619(Tax:10090)	12390(Tax:10090)	Gene	Gene	Mice|amod|START_ENTITY END_ENTITY|nmod|Mice	Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin_26 Deficient Mice .
11746015	0	Connexin_26	0,11	GJB2	18,22	Connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Connexin_26 gene -LRB- GJB2 -RRB- mutation modulates the severity of hearing_loss associated with the 1555A -- > G mitochondrial mutation .
18950394	0	Connexin_26	24,35	GJB2	12,16	Connexin 26	GJB2	2706	2706	Gene	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	A report of GJB2 -LRB- N14K -RRB- Connexin_26 mutation in two patients -- a new subtype of KID_syndrome ?
25298064	0	Connexin_26	44,55	GJB2	38,42	Connexin 26	GJB2	2706	2706	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Electroporation Transiently Decreases GJB2 -LRB- Connexin_26 -RRB- Expression in B16/BL6 Melanoma Cell Line .
26088551	0	Connexin_26	114,125	GJB2	108,112	Connexin 26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Non-syndromic_hearing_loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 -LRB- Connexin_26 -RRB- gene .
12630965	0	Connexin_31	21,32	GJB3	34,38	Connexin 31	GJB3	2707	2707	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Mutation analysis of Connexin_31 -LRB- GJB3 -RRB- in sporadic non-syndromic_hearing_impairment .
11734543	0	Connexin_32	6,17	SOX10	153,158	Connexin 32	SOX10	2705	6663	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Human Connexin_32 , a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth_disease , is directly regulated by the transcription factor SOX10 .
19218461	0	Connexin_32	0,11	neuregulin-1	69,81	Connexin 32	neuregulin-1	14618(Tax:10090)	211323(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Connexin_32 increases the proliferative response of Schwann cells to neuregulin-1 -LRB- Nrg1 -RRB- .
17579252	0	Connexin_36	0,11	zonula_occludens-1_protein	45,71	Connexin 36	zonula occludens-1 protein	50564(Tax:10116)	292994(Tax:10116)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Connexin_36 is expressed and associated with zonula_occludens-1_protein in PC-12 cells .
15923624	0	Connexin_40	0,11	Tbx5	46,50	Connexin 40	Tbx5	14613(Tax:10090)	21388(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Connexin_40 , a target of transcription factor Tbx5 , patterns wrist , digits , and sternum .
22736223	0	Connexin_43	0,11	Bax	27,30	Connexin 43	Bax	2697	581	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Connexin_43 interacts with Bax to regulate apoptosis of pancreatic_cancer through a gap junction-independent pathway .
26599051	0	Connexin_43	16,27	C-Jun	44,49	Connexin 43	C-Jun	2697	3725	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Upregulation of Connexin_43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease .
26721509	0	Connexin_43	0,11	CXCL12	21,27	Connexin 43	CXCL12	24392(Tax:10116)	24772(Tax:10116)	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Connexin_43 Mediates CXCL12 Production from Spinal Dorsal Horn to Maintain Bone_Cancer_Pain in Rats .
18687515	0	Connexin_43	17,28	Cx43	30,34	Connexin 43	Cx43	2697	2697	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A pilot study of Connexin_43 -LRB- Cx43 -RRB- in human bladder tissue in patients with idiopathic_detrusor_overactivity .
26748803	0	Connexin_43	0,11	Cx43	13,17	Connexin 43	Cx43	2697	2697	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Connexin_43 -LRB- Cx43 -RRB- Expression in Laryngeal_Squamous_Cell_Carcinomas : Preliminary Data on Its Possible Prognostic Role .
26334722	0	Connexin_43	0,11	ERK1/2	99,105	Connexin 43	ERK1/2	2697	5595;5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Connexin_43 promotes ossification_of_the_posterior_longitudinal_ligament through activation of the ERK1/2 and p38 MAPK pathways .
19854131	0	Conserved_telomere_maintenance_component_1	0,42	STN1	58,62	Conserved telomere maintenance component 1	STN1	80169	79991	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Conserved_telomere_maintenance_component_1 interacts with STN1 and maintains chromosome ends in higher eukaryotes .
23340159	0	Constitutive_androstane_receptor	0,32	Abcb1	45,50	Constitutive androstane receptor	Abcb1	9970	5243	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Constitutive_androstane_receptor upregulates Abcb1 and Abcg2 at the blood-brain barrier after CITCO activation .
16799968	0	Constitutive_androstane_receptor	0,32	CAR	34,37	Constitutive androstane receptor	CAR	12355(Tax:10090)	12355(Tax:10090)	Gene	Gene	ligand|amod|START_ENTITY ligand|appos|END_ENTITY	Constitutive_androstane_receptor -LRB- CAR -RRB- ligand , TCPOBOP , attenuates Fas-induced murine liver_injury by altering Bcl-2 proteins .
19682433	0	Constitutive_androstane_receptor	0,32	CYP1A1	67,73	Constitutive androstane receptor	CYP1A1	9970	1543	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Constitutive_androstane_receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5 ' - flanking region .
9698766	0	Constitutive_nitric_oxide_synthase	0,34	cNOS	36,40	Constitutive nitric oxide synthase	cNOS	24600(Tax:10116)	24600(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Constitutive_nitric_oxide_synthase -LRB- cNOS -RRB- activity in Langerhans islets from streptozotocin diabetic rats .
23724143	0	Contactin-1	0,11	E-cadherin	20,30	Contactin-1	E-cadherin	1272	999	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Contactin-1 reduces E-cadherin expression via activating AKT in lung_cancer .
21403399	0	Cop1	0,4	c-Jun	30,35	Cop1	c-Jun	26374(Tax:10090)	16476(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice .
20010870	0	Copine-III	0,10	ErbB2	26,31	Copine-III	ErbB2	8895	2064	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Copine-III interacts with ErbB2 and promotes tumor cell migration .
16365053	0	Copper_transport_protein	0,24	Ctr1	26,30	Copper transport protein	Ctr1	20529(Tax:10090)	20529(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Copper_transport_protein -LRB- Ctr1 -RRB- levels in mice are tissue specific and dependent on copper status .
25681392	0	Copr5	70,75	Dlk-1	20,25	Copr5	Dlk-1	66423(Tax:10090)	13386(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion .
12434152	0	Core-binding_factor_beta	0,24	Runx2	40,45	Core-binding factor beta	Runx2	12400(Tax:10090)	12393(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Core-binding_factor_beta interacts with Runx2 and is required for skeletal development .
26531617	0	Coronin-1	0,9	neurotrophin	30,42	Coronin-1	neurotrophin	11151	627	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Coronin-1 mediates hierarchal neurotrophin signaling required for sympathetic neuron target innervation .
22563075	0	Coronin1B	78,87	neuregulin_1	99,111	Coronin1B	neuregulin 1	57175	3084	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Novel mechanism for negatively regulating Rho-kinase -LRB- ROCK -RRB- signaling through Coronin1B protein in neuregulin_1 -LRB- NRG-1 -RRB- - induced tumor cell motility .
23562652	0	Coronin_1B	42,52	Wt1	28,31	Coronin 1B	Wt1	23789(Tax:10090)	22431(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The Wilms ' _ tumor suppressor Wt1 regulates Coronin_1B expression in the epicardium .
18775315	0	Coronin_1B	0,10	cortactin	23,32	Coronin 1B	cortactin	57175	2017	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Coronin_1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia .
19654210	0	Coronin_2A	0,10	cofilin	76,83	Coronin 2A	cofilin	7464	1072	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	Coronin_2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway .
15327992	0	Coronin_7	0,9	POD-1	25,30	Coronin 7	POD-1	79585	79585	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Coronin_7 , the mammalian POD-1 homologue , localizes to the Golgi apparatus .
22952966	0	Cortactin	0,9	Cdc42-associated_kinase_1	38,63	Cortactin	Cdc42-associated kinase 1	2017	10188	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Cortactin is a substrate of activated Cdc42-associated_kinase_1 -LRB- ACK1 -RRB- during ligand-induced epidermal_growth_factor_receptor downregulation .
26151562	0	Cortactin	0,9	ERK	58,61	Cortactin	ERK	2017	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Cortactin promotes colon_cancer progression by regulating ERK pathway .
26151562	0	Cortactin	0,9	ERK	58,61	Cortactin	ERK	2017	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Cortactin promotes colon_cancer progression by regulating ERK pathway .
15585574	0	Cortactin	0,9	N-WASP	57,63	Cortactin	N-WASP	2017	8976	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Cortactin regulates cell migration through activation of N-WASP .
15383621	0	Cortactin	0,9	N-cadherin	26,36	Cortactin	N-cadherin	60465(Tax:10116)	83501(Tax:10116)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts .
20805359	0	Cortactin	0,9	RhoA	20,24	Cortactin	RhoA	2017	387	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activation activation|compound|END_ENTITY	Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head_and_neck_squamous_cell_carcinoma cells .
25077552	0	Cortactin	74,83	Src	0,3	Cortactin	Src	2017	6714	Gene	Gene	Phosphorylation|compound|START_ENTITY Recycling|nmod|Phosphorylation END_ENTITY|dobj|Recycling	Src Regulates Sequence-Dependent Beta-2_Adrenergic_Receptor Recycling via Cortactin Phosphorylation .
8643668	0	Cortactin	74,83	Src	31,34	Cortactin	Src	2017	6714	Gene	Gene	Crk|appos|START_ENTITY homology|nmod|Crk homology|nsubj|preferences preferences|nmod|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
8643668	0	Cortactin	74,83	Src	59,62	Cortactin	Src	2017	6714	Gene	Gene	Crk|appos|START_ENTITY Crk|compound|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
12620186	0	Cortactin	0,9	WIP	25,28	Cortactin	WIP	2017	7456	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion .
9792678	0	Cortactin	0,9	ZO-1	57,61	Cortactin	ZO-1	42491(Tax:7227)	41062(Tax:7227)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse .
19704022	0	Cortactin	0,9	cofilin	20,27	Cortactin	cofilin	2017	1072	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activities activities|compound|END_ENTITY	Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation .
19684413	0	Cortactin	0,9	podocalyxin	25,36	Cortactin	podocalyxin	60465(Tax:10116)	192181(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cortactin interacts with podocalyxin and mediates morphological change of podocytes through its phosphorylation .
25406021	0	Corticotropin-Releasing_Factor	73,103	Relaxin-3	24,33	Corticotropin-Releasing Factor	Relaxin-3	81648(Tax:10116)	266997(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Sex-Specific Effects of Relaxin-3 on Food Intake and Brain Expression of Corticotropin-Releasing_Factor in Rats .
21819464	0	Corticotropin-releasing_factor	0,30	CREB	56,60	Corticotropin-releasing factor	CREB	81648(Tax:10116)	81646(Tax:10116)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Corticotropin-releasing_factor and urocortin_I activate CREB through functionally selective Gby signaling in hippocampal pyramidal neurons .
16001267	0	Corticotropin-releasing_factor	0,30	CRF	32,35	Corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- expression in postnatal and adult rat sacral parasympathetic nucleus -LRB- SPN -RRB- .
21964377	0	Corticotropin-releasing_factor	0,30	CRF	32,35	Corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- receptor subtypes in mediating neuronal activation of brain areas involved in responses to intracerebroventricular CRF and stress in rats .
2546128	0	Corticotropin-releasing_factor	0,30	CRF	32,35	Corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- receptors in intermediate lobe of the pituitary : biochemical characterization and autoradiographic localization .
6383518	0	Corticotropin-releasing_factor	0,30	CRF	32,35	Corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- immunoreactivity in the dorsolateral pontine tegmentum : further studies on the micturition reflex system .
16545343	0	Corticotropin-releasing_factor	0,30	CRF-binding_protein	93,112	Corticotropin-releasing factor	CRF-binding protein	81648(Tax:10116)	29625(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- , but not corticosterone , increases basolateral amygdala CRF-binding_protein .
12895416	0	Corticotropin-releasing_factor	0,30	CRF_binding_protein	40,59	Corticotropin-releasing factor	CRF binding protein	1392	1393	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Corticotropin-releasing_factor requires CRF_binding_protein to potentiate NMDA receptors via CRF_receptor_2 in dopamine neurons .
18803662	0	Corticotropin-releasing_factor	0,30	IL-18	41,46	Corticotropin-releasing factor	IL-18	1392	3606	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Corticotropin-releasing_factor decreases IL-18 in the monocyte-derived dendritic cell .
16424218	0	Corticotropin-releasing_factor	0,30	TLR4	75,79	Corticotropin-releasing factor	TLR4	12918(Tax:10090)	21898(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Corticotropin-releasing_factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU .1 and AP-1 .
20732324	0	Corticotropin-releasing_factor	0,30	TLR4	41,45	Corticotropin-releasing factor	TLR4	12918(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Corticotropin-releasing_factor regulates TLR4 expression in the colon and protects mice from colitis .
3000730	0	Corticotropin-releasing_factor	0,30	adrenocorticotropin	57,76	Corticotropin-releasing factor	adrenocorticotropin	1392	5443	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Corticotropin-releasing_factor stimulates the release of adrenocorticotropin from domestic fowl pituitary cells .
18930089	0	Corticotropin-releasing_factor	0,30	alpha-melanocyte-stimulating_hormone	81,117	Corticotropin-releasing factor	alpha-melanocyte-stimulating hormone	12918(Tax:10090)	18976(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|effect effect|nmod|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- is involved in the acute anorexic effect of alpha-melanocyte-stimulating_hormone : a study using CRF-deficient mice .
10513602	0	Corticotropin-releasing_factor	0,30	brain-derived_neurotrophic_factor	40,73	Corticotropin-releasing factor	brain-derived neurotrophic factor	81648(Tax:10116)	24225(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Corticotropin-releasing_factor enhances brain-derived_neurotrophic_factor gene expression to facilitate memory retention in rats .
8264665	0	Corticotropin-releasing_factor	0,30	c-fos	41,46	Corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Corticotropin-releasing_factor activates c-fos , NGFI-B , and corticotropin-releasing_factor gene expression within the paraventricular nucleus of the rat hypothalamus .
3524753	0	Corticotropin-releasing_factor	0,30	gonadotropin-releasing_hormone	46,76	Corticotropin-releasing factor	gonadotropin-releasing hormone	81648(Tax:10116)	25194(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- inhibits gonadotropin-releasing_hormone -LRB- GnRH -RRB- release from superfused rat hypothalami in vitro .
22971074	0	Corticotropin-releasing_hormone	0,31	11beta-HSD2	65,76	Corticotropin-releasing hormone	11beta-HSD2	1392	3291	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Corticotropin-releasing_hormone stimulates expression of leptin , 11beta-HSD2 and syncytin-1 in primary human trophoblasts .
12694378	0	Corticotropin-releasing_hormone	0,31	CRH	33,36	Corticotropin-releasing hormone	CRH	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- expression and protein kinase A mediated CRH receptor signalling in an immortalized hypothalamic cell line .
18805429	0	Corticotropin-releasing_hormone	0,31	CRH-R1	40,46	Corticotropin-releasing hormone	CRH-R1	1392	1394	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Corticotropin-releasing_hormone acts on CRH-R1 to inhibit the spontaneous contractility of non-labouring human myometrium at term .
26363222	0	Corticotropin-releasing_hormone	0,31	CRH_type_1_receptor	127,146	Corticotropin-releasing hormone	CRH type 1 receptor	404297(Tax:9031)	374218(Tax:9031)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- stimulates cocaine - _ and_amphetamine-regulated_transcript gene -LRB- CART1 -RRB- expression through CRH_type_1_receptor -LRB- CRHR1 -RRB- in chicken anterior pituitary .
22000570	0	Corticotropin-releasing_hormone	0,31	IL-10	46,51	Corticotropin-releasing hormone	IL-10	1392	3586	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Corticotropin-releasing_hormone downregulates IL-10 production by adaptive forkhead box protein 3-negative regulatory T cells in patients with atopic_dermatitis .
11602623	0	Corticotropin-releasing_hormone	0,31	IL-6	42,46	Corticotropin-releasing hormone	IL-6	12918(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Corticotropin-releasing_hormone regulates IL-6 expression during inflammation .
15171702	0	Corticotropin-releasing_hormone	0,31	NF-kappaB	43,52	Corticotropin-releasing hormone	NF-kappaB	1392	4790	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Corticotropin-releasing_hormone stimulates NF-kappaB in human epidermal keratinocytes .
18713960	0	Corticotropin-releasing_hormone	0,31	SGK-1	43,48	Corticotropin-releasing hormone	SGK-1	1392	6446	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Corticotropin-releasing_hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1 .
8854136	0	Corticotropin-releasing_hormone	0,31	alpha-melanocyte-stimulating_hormone	57,93	Corticotropin-releasing hormone	alpha-melanocyte-stimulating hormone	1392	5443	Gene	Gene	administration|amod|START_ENTITY increases|nsubj|administration increases|dobj|levels levels|amod|END_ENTITY	Corticotropin-releasing_hormone administration increases alpha-melanocyte-stimulating_hormone levels in the inferior petrosal sinuses in a subset of patients with Cushing 's _ disease .
17895291	0	Corticotropin-releasing_hormone	0,31	connexin_43	42,53	Corticotropin-releasing hormone	connexin 43	1392	2697	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Corticotropin-releasing_hormone activates connexin_43 via activator_protein-1 transcription factor in human myometrial smooth muscle cells .
15816833	0	Corticotropin-releasing_hormone	0,31	interleukin-18	52,66	Corticotropin-releasing hormone	interleukin-18	1392	3606	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- downregulates interleukin-18 expression in human HaCaT keratinocytes by activation of p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- pathway .
22698524	0	Corticotropin-releasing_hormone	0,31	mitotic_kinesin-like_protein_1	43,73	Corticotropin-releasing hormone	mitotic kinesin-like protein 1	1392	9493	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Corticotropin-releasing_hormone stimulates mitotic_kinesin-like_protein_1 expression via a PLC/PKC-dependent signaling pathway in hippocampal neurons .
17470519	0	Corticotropin-releasing_hormone	0,31	proopiomelanocortin	63,82	Corticotropin-releasing hormone	proopiomelanocortin	81648(Tax:10116)	24664(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Corticotropin-releasing_hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter .
11070336	0	Corticotropin-releasing_hormone	0,31	tyrosine_hydroxylase	121,141	Corticotropin-releasing hormone	tyrosine hydroxylase	81648(Tax:10116)	25085(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY rise|nsubj|levels rise|advcl|decrease decrease|nsubj|levels levels|amod|END_ENTITY	Corticotropin-releasing_hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine_hydroxylase mRNA levels decrease in both sexes .
19852986	0	Corticotropin-releasing_hormone	0,31	vascular_endothelial_growth_factor	43,77	Corticotropin-releasing hormone	vascular endothelial growth factor	1392	7422	Gene	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Corticotropin-releasing_hormone attenuates vascular_endothelial_growth_factor release from human HaCaT keratinocytes .
26350463	0	Corticotropin_Releasing_Hormone	0,31	Vascular_Endothelial_Growth_Factor	58,92	Corticotropin Releasing Hormone	Vascular Endothelial Growth Factor	1392	7422	Gene	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Corticotropin_Releasing_Hormone and Urocortin_3 Stimulate Vascular_Endothelial_Growth_Factor Expression through the cAMP/CREB Pathway .
1943449	0	Corticotropin_releasing_factor	0,30	growth_hormone	42,56	Corticotropin releasing factor	growth hormone	81648(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Corticotropin_releasing_factor stimulates growth_hormone secretion in neonatal rats .
23686762	0	Corticotropin_releasing_hormone	0,31	CD14	42,46	Corticotropin releasing hormone	CD14	1392	929	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|amod|END_ENTITY	Corticotropin_releasing_hormone activates CD14 -LRB- + -RRB- cells to induce endothelial_barrier_dysfunction .
22703673	0	Corticotropin_releasing_hormone	0,31	CRH	33,36	Corticotropin releasing hormone	CRH	1392	1392	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Corticotropin_releasing_hormone -LRB- CRH -RRB- response in patients with early rheumatoid_arthritis due to polymorphisms in the CRH gene .
22342595	0	Cortistatin	0,11	corticotrophin_releasing_hormone	52,84	Cortistatin	corticotrophin releasing hormone	25305(Tax:10116)	81648(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Cortistatin modulates the expression and release of corticotrophin_releasing_hormone in rat brain .
21401930	0	Corto	86,91	ERK	15,18	Corto	ERK	40616(Tax:7227)	3354888(Tax:7227)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development .
18202089	0	Cosmc	54,59	IgA_nephropathy	68,83	Cosmc	IgA nephropathy	29071	60498	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	External suppression causes the low expression of the Cosmc gene in IgA_nephropathy .
23136028	0	Cosmc	77,82	IgA_nephropathy	97,112	Cosmc	IgA nephropathy	29071	60498	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Mycophenolic_acid reverses IgA1 aberrant glycosylation through up-regulating Cosmc expression in IgA_nephropathy .
24616093	0	Cosmc	98,103	T-synthase	59,69	Cosmc	T-synthase	29071	56913	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel protein binding motif within the T-synthase for the molecular chaperone Cosmc .
11932422	0	Cot	35,38	NF-kappaB	125,134	Cot	NF-kappaB	1326	4790	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	The oncogenic protein kinase Tpl-2 / Cot contributes to Epstein-Barr_virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2 .
11932422	0	Cot	35,38	Tpl-2	29,34	Cot	Tpl-2	1326	1326	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|parataxis|contributes	The oncogenic protein kinase Tpl-2 / Cot contributes to Epstein-Barr_virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2 .
23080298	0	Cot	26,29	Tumor_progression_locus_2	0,25	Cot	Tumor progression locus 2	26410(Tax:10090)	26410(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	Tumor_progression_locus_2 / Cot is required for activation of extracellular regulated kinase in liver_injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice .
20736176	0	Cot/tpl2	0,8	MAP3K8	10,16	Cot/tpl2	MAP3K8	26410(Tax:10090)	26410(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Cot/tpl2 -LRB- MAP3K8 -RRB- mediates myeloperoxidase activity and hypernociception following peripheral inflammation .
24532642	0	Cot/tpl2	0,8	adiponectin	58,69	Cot/tpl2	adiponectin	1326	9370	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	Cot/tpl2 participates in the activation of macrophages by adiponectin .
20736176	0	Cot/tpl2	0,8	myeloperoxidase	27,42	Cot/tpl2	myeloperoxidase	26410(Tax:10090)	17523(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Cot/tpl2 -LRB- MAP3K8 -RRB- mediates myeloperoxidase activity and hypernociception following peripheral inflammation .
19106112	0	Coupling_factor_6	0,17	angiotensin_II	58,72	Coupling factor 6	angiotensin II	11957(Tax:10090)	24179(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Coupling_factor_6 enhances Src-mediated responsiveness to angiotensin_II in resistance arterioles and cells .
18243211	0	Coupling_factor_6	0,17	platelet_endothelial_cell_adhesion_molecule-1	32,77	Coupling factor 6	platelet endothelial cell adhesion molecule-1	522	5175	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Coupling_factor_6 downregulates platelet_endothelial_cell_adhesion_molecule-1 via c-Src activation and acts as a proatherogenic molecule .
17876541	0	Cox-2	30,35	CDX2	17,21	Cox-2	CDX2	5743	1045	Gene	Gene	transcription|compound|START_ENTITY reduces|dobj|transcription reduces|nsubj|END_ENTITY	Homeobox protein CDX2 reduces Cox-2 transcription by inactivating the DNA-binding capacity of nuclear factor-kappaB .
24887090	0	Cox-2	50,55	E-cadherin	15,25	Cox-2	E-cadherin	5743	999	Gene	Gene	inhibition|compound|START_ENTITY Restoration|nmod|inhibition Restoration|nmod|expression expression|amod|END_ENTITY	Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head_and_neck_squamous_cell_carcinoma .
26035123	0	Cox-2	18,23	Mucin_1	0,7	Cox-2	Mucin 1	5743	4582	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	Mucin_1 Regulates Cox-2 gene in Pancreatic_Cancer .
16952555	0	Cox-2	0,5	Toll-like_receptor-4	22,42	Cox-2	Toll-like receptor-4	19225(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cox-2 is regulated by Toll-like_receptor-4 -LRB- TLR4 -RRB- signaling : Role in proliferation and apoptosis in the intestine .
17250449	0	Cox-2	103,108	caspase-3	126,135	Cox-2	caspase-3	17709(Tax:10090)	12367(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Black tea polyphenols restrict benzopyrene-induced mouse lung_cancer progression through inhibition of Cox-2 and induction of caspase-3 expression .
17540723	0	Cox-2	0,5	chromogranin_A	15,29	Cox-2	chromogranin A	5743	1113	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Cox-2 promotes chromogranin_A expression and bioactivity : evidence for a prostaglandin_E2-dependent mechanism and the involvement of a proximal cyclic_adenosine_5 ' - monophosphate-responsive element .
16099597	0	Cox-2	55,60	cyclooxygenase-2	37,53	Cox-2	cyclooxygenase-2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nuclear_factor_kappaB -LRB- NFkappaB -RRB- and cyclooxygenase-2 -LRB- Cox-2 -RRB- expression in the irradiated colorectum is associated with subsequent histopathological changes .
16274925	0	Cox-2	48,53	cyclooxygenase-2	30,46	Cox-2	cyclooxygenase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tissue-specific modulation of cyclooxygenase-2 -LRB- Cox-2 -RRB- expression in the uterus and the v. cava by estrogens and phytoestrogens .
16496341	0	Cox-2	83,88	cyclooxygenase-2	65,81	Cox-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 -LRB- Cox-2 -RRB- gene .
16557423	0	Cox-2	26,31	cyclooxygenase-2	8,24	Cox-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Imaging cyclooxygenase-2 -LRB- Cox-2 -RRB- gene expression in living animals with a luciferase knock-in reporter gene .
12411481	0	Cox-2	26,31	p53	44,47	Cox-2	p53	5743	7157	Gene	Gene	induction|nmod|START_ENTITY counteracts|nsubj|induction counteracts|dobj|apoptosis apoptosis|amod|END_ENTITY	P53-mediated induction of Cox-2 counteracts p53 - or genotoxic stress-induced apoptosis .
19710419	0	Cox1	44,48	Mss51	18,23	Cox1	Mss51	854598(Tax:4932)	850900(Tax:4932)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces_cerevisiae mitochondria .
10803883	0	Cox1p	119,124	Mss51p	0,6	Cox1p	Mss51p	854598(Tax:4932)	850900(Tax:4932)	Gene	Gene	synthesis|nmod|START_ENTITY required|nmod|synthesis required|nsubjpass|END_ENTITY	Mss51p , a putative translational activator of cytochrome_c_oxidase_subunit-1 -LRB- COX1 -RRB- mRNA , is required for synthesis of Cox1p in Saccharomyces_cerevisiae .
14592991	0	Cox1p	30,35	Mss51p	0,6	Cox1p	Mss51p	4512	118490	Gene	Gene	synthesis|amod|START_ENTITY promotes|dobj|synthesis promotes|nsubj|END_ENTITY	Mss51p promotes mitochondrial Cox1p synthesis and interacts with newly synthesized Cox1p .
14592991	0	Cox1p	83,88	Mss51p	0,6	Cox1p	Mss51p	4512	118490	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Mss51p promotes mitochondrial Cox1p synthesis and interacts with newly synthesized Cox1p .
15306853	0	Cox1p	49,54	Mss51p	0,6	Cox1p	Mss51p	854598(Tax:4932)	850900(Tax:4932)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces_cerevisiae .
16841169	0	Coxsackie-Adenovirus_receptor	14,43	CAR	45,48	Coxsackie-Adenovirus receptor	CAR	13052(Tax:10090)	13052(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Coxsackie-Adenovirus_receptor -LRB- CAR -RRB- in the developing mouse olfactory system .
15533241	0	Coxsackie_and_adenovirus_receptor	35,68	CAR	70,73	Coxsackie and adenovirus receptor	CAR	1525	1525	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Isoform-specific expression of the Coxsackie_and_adenovirus_receptor -LRB- CAR -RRB- in neuromuscular junction and cardiac intercalated discs .
25497012	0	Coxsackie_virus_and_Adenovirus_Receptor	42,81	miR-466	0,7	Coxsackie virus and Adenovirus Receptor	miR-466	1525	100423038	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	miR-466 is putative negative regulator of Coxsackie_virus_and_Adenovirus_Receptor .
21674029	0	Coxsackievirus_and_Adenovirus_Receptor	64,102	Car	104,107	Coxsackievirus and Adenovirus Receptor	Car	13052(Tax:10090)	13052(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiple phenotypes in adult mice following inactivation of the Coxsackievirus_and_Adenovirus_Receptor -LRB- Car -RRB- gene .
18082152	0	CpG_binding_protein	6,25	MLL1	41,45	CpG binding protein	MLL1	30827	4297	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human CpG_binding_protein interacts with MLL1 , MLL2 and hSet1 and regulates Hox gene expression .
16455656	0	CpNifS	42,48	CpSufE	0,6	CpNifS	CpSufE	837370(Tax:3702)	828756(Tax:3702)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	CpSufE activates the cysteine desulfurase CpNifS for chloroplastic Fe-S cluster formation .
16455656	0	CpSufE	0,6	CpNifS	42,48	CpSufE	CpNifS	828756(Tax:3702)	837370(Tax:3702)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CpSufE activates the cysteine desulfurase CpNifS for chloroplastic Fe-S cluster formation .
19767734	0	Cpe	32,35	FoxO1	42,47	Cpe	FoxO1	12876(Tax:10090)	56458(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake .
16151221	0	Cpn10	35,40	chaperonin_10	20,33	Cpn10	chaperonin 10	3336	3336	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of chaperonin_10 -LRB- Cpn10 -RRB- from the intestinal human pathogen Entamoeba_histolytica .
23905631	0	Cpt1a	43,48	HDAC3	22,27	Cpt1a	HDAC3	12894(Tax:10090)	15183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Binge ethanol-induced HDAC3 down-regulates Cpt1a expression leading to hepatic_steatosis and injury .
1534100	0	Cr2	91,94	Oct-1	68,73	Cr2	Oct-1	12902(Tax:10090)	18986(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Identification of sites for distinct DNA binding proteins including Oct-1 and Oct-2 in the Cr2 gene .
17270348	0	Crad3	18,23	rdh9	12,16	Crad3	rdh9	103142(Tax:10090)	103142(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ontogeny of rdh9 -LRB- Crad3 -RRB- expression : ablation causes changes in retinoid and steroid metabolizing enzymes , but RXR and androgen signaling seem normal .
21484995	0	Crb1	56,60	Crumbs_homologue_1	36,54	Crb1	Crumbs homologue 1	23418	23418	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Homozygosity mapping identifies the Crumbs_homologue_1 -LRB- Crb1 -RRB- gene as responsible for a recessive_syndrome of retinitis_pigmentosa and nanophthalmos .
10488332	0	Crb2	24,28	Cdc2	0,4	Crb2	Cdc2	286204	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cdc2 phosphorylation of Crb2 is required for reestablishing cell cycle progression after the damage checkpoint .
26580434	0	Creatine_Kinase_Muscle	54,76	CK-M	78,82	Creatine Kinase Muscle	CK-M	100065641(Tax:9796)	100065641(Tax:9796)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Molecular Characterization and Expression Analysis of Creatine_Kinase_Muscle -LRB- CK-M -RRB- Gene in Horse .
22078933	0	Creb	95,99	SirT1	52,57	Creb	SirT1	12912(Tax:10090)	93759(Tax:10090)	Gene	Gene	deacetylation|compound|START_ENTITY mediated|nmod|deacetylation mediated|nsubjpass|Proatherogenic_abnormalities Proatherogenic_abnormalities|nmod|metabolism metabolism|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Proatherogenic_abnormalities of lipid metabolism in SirT1 transgenic_mice are mediated through Creb deacetylation .
11673262	0	Cres	107,111	cystatin-related_epididymal_spermatogenic	64,105	Cres	cystatin-related epididymal spermatogenic	13012(Tax:10090)	13012(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	CCAAT/enhancer _ binding_protein beta regulates expression of the cystatin-related_epididymal_spermatogenic -LRB- Cres -RRB- gene .
17486270	0	Cres	75,79	cystatin-related_epididymal_spermatogenic	32,73	Cres	cystatin-related epididymal spermatogenic	13012(Tax:10090)	13012(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Age-dependent expression of the cystatin-related_epididymal_spermatogenic -LRB- Cres -RRB- gene in mouse testis and epididymis .
26338335	0	Crf	34,37	CREB-Regulated_Transcription_Coactivator_3	65,107	Crf	CREB-Regulated Transcription Coactivator 3	1392	64784	Gene	Gene	Transcription|compound|START_ENTITY Transcription|nmod|END_ENTITY	Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated_Transcription_Coactivator_3 .
25453556	0	Crimpy	0,6	BMP	73,76	Crimpy	BMP	40288(Tax:7227)	37778(Tax:7227)	Gene	Gene	Discrimination|compound|START_ENTITY Discrimination|nmod|END_ENTITY	Crimpy Enables Discrimination of Presynaptic and Postsynaptic Pools of a BMP at the Drosophila Neuromuscular Junction .
18772886	0	Cripto	0,6	Furin	16,21	Cripto	Furin	6998	5045	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation .
19421146	0	Cripto	12,18	GRP78	43,48	Cripto	GRP78	6998	3309	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways .
19421146	0	Cripto	68,74	GRP78	43,48	Cripto	GRP78	6998	3309	Gene	Gene	signaling|compound|START_ENTITY inhibits|dobj|signaling inhibits|nsubj|Blockade Blockade|nmod|binding binding|nmod|END_ENTITY	Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways .
21982233	0	Cripto	0,6	GRP78	106,111	Cripto	GRP78	21667(Tax:10090)	14828(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78 .
17030617	0	Cripto	0,6	transforming_growth_factor_beta	13,44	Cripto	transforming growth factor beta	6997	7040	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Cripto binds transforming_growth_factor_beta -LRB- TGF-beta -RRB- and inhibits TGF-beta signaling .
12807879	0	Crk	70,73	CT10_regulator_of_kinase	44,68	Crk	CT10 regulator of kinase	1398	1398	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Pseudomonas_aeruginosa ExoT ADP-ribosylates CT10_regulator_of_kinase -LRB- Crk -RRB- proteins .
10618718	0	Crk	62,65	Crk	97,100	Crk	Crk	1398	1398	Gene	Gene	mediated|nmod|START_ENTITY mediated|parataxis|signaling signaling|nsubj|END_ENTITY	Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation .
10618718	0	Crk	97,100	Crk	62,65	Crk	Crk	1398	1398	Gene	Gene	signaling|nsubj|START_ENTITY mediated|parataxis|signaling mediated|nmod|END_ENTITY	Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation .
12894221	0	Crk	56,59	CrkIII	0,6	Crk	CrkIII	12928(Tax:10090)	12928(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	CrkIII : a novel and biologically distinct member of the Crk family of adaptor proteins .
10618718	0	Crk	62,65	Gab1	90,94	Crk	Gab1	1398	2549	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation .
10618718	0	Crk	97,100	Gab1	90,94	Crk	Gab1	1398	2549	Gene	Gene	signaling|nsubj|START_ENTITY mediated|parataxis|signaling mediated|nmod|END_ENTITY	Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation .
19350053	0	Crk	0,3	Gab1	47,51	Crk	Gab1	1398	2549	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration .
10777559	0	Crk	0,3	JNK	18,21	Crk	JNK	12928(Tax:10090)	26419(Tax:10090)	Gene	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Crk activation of JNK via C3G and R-Ras .
25027343	0	Crk	74,77	MiR-126	0,7	Crk	MiR-126	1398	406913	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-126 inhibits the invasion of gastric_cancer cell in part by targeting Crk .
11175351	0	Crk	4,7	Rap1	93,97	Crk	Rap1	12928(Tax:10090)	109905(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY contributes|nsubj|signaling contributes|nmod|activation activation|nmod|END_ENTITY	The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss_3T3 cells .
8524240	0	Crk	43,46	Rap1	18,22	Crk	Rap1	1398	5906	Gene	Gene	C3G|compound|START_ENTITY Identification|nmod|C3G Identification|nmod|END_ENTITY	Identification of Rap1 as a target for the Crk SH3 domain-binding guanine_nucleotide-releasing factor C3G .
9268367	0	Crk	89,92	Rap1	63,67	Crk	Rap1	1398	27342	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk , CrkL , and Grb2 .
10419455	0	Crk	109,112	ZAP-70	93,99	Crk	ZAP-70	1398	7535	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins .
12138161	0	Crk	0,3	epidermal_growth_factor	20,43	Crk	epidermal growth factor	1398	1950	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Crk synergizes with epidermal_growth_factor for epithelial invasion and morphogenesis and is required for the met morphogenic program .
8183562	0	Crk	102,105	p130	117,121	Crk	p130	12928(Tax:10090)	70769(Tax:10090)	Gene	Gene	START_ENTITY|acl|associated associated|dobj|END_ENTITY	The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat_3Y1 cells .
18465784	0	Crk-associated_substrate_lymphocyte_type	43,83	Cas-L	85,90	Crk-associated substrate lymphocyte type	Cas-L	4739	4739	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Expression and tyrosine phosphorylation of Crk-associated_substrate_lymphocyte_type -LRB- Cas-L -RRB- protein in human neutrophils .
25307974	0	Crk-like_adapter_protein	0,24	AKT	55,58	Crk-like adapter protein	AKT	1399	207	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Crk-like_adapter_protein is required for TGF-b-induced AKT and ERK-signaling pathway in epithelial_ovarian_carcinomas .
16740993	0	CrkII	0,5	BCAR3	22,27	CrkII	BCAR3	1398	8412	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	CrkII associates with BCAR3 in response to endothelin-1 in human glomerular mesangial cells .
11870224	0	CrkII	100,105	Ephrin-A5	0,9	CrkII	Ephrin-A5	1398	1946	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Ephrin-A5 induces rounding , blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling .
15598735	0	CrkII	0,5	focal_adhesion_kinase	16,37	CrkII	focal adhesion kinase	1398	5747	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	CrkII regulates focal_adhesion_kinase activation by making a complex with Crk-associated_substrate , p130Cas .
12955073	0	CrkII	0,5	serum_response_factor	14,35	CrkII	serum response factor	12928(Tax:10090)	20807(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	CrkII induces serum_response_factor activation and cellular transformation through its function in Rho activation .
12894221	0	CrkIII	0,6	Crk	56,59	CrkIII	Crk	12928(Tax:10090)	12928(Tax:10090)	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	CrkIII : a novel and biologically distinct member of the Crk family of adaptor proteins .
12522101	0	CrkL	0,4	ASAP1	13,18	CrkL	ASAP1	1399	50807	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|END_ENTITY	CrkL directs ASAP1 to peripheral focal adhesions .
11389015	0	CrkL	20,24	CD34	41,45	CrkL	CD34	1399	947	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	The adapter protein CrkL associates with CD34 .
12393632	0	CrkL	22,26	DOCK2	0,5	CrkL	DOCK2	1399	1794	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines .
25476480	0	CrkL	0,4	Erk1/2	69,75	CrkL	Erk1/2	1399	5595;5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	CrkL regulates SDF-1-induced breast_cancer biology through balancing Erk1/2 and PI3K/Akt pathways .
9837784	0	CrkL	15,19	STAT5	25,30	CrkL	STAT5	1399	6776	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage_colony-stimulating_factor or erythropoietin .
20136656	0	CrkL	0,4	Sprouty2	26,34	CrkL	Sprouty2	12929(Tax:10090)	24064(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling .
21700719	0	CrkL	0,4	estrogen_receptor_alpha	26,49	CrkL	estrogen receptor alpha	1399	2099	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	CrkL is a co-activator of estrogen_receptor_alpha that enhances tumorigenic potential in cancer .
16158059	0	Crk_II	30,36	Abl	19,22	Crk II	Abl	1398	25	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Transactivation of Abl by the Crk_II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain .
11245441	0	Crkl	0,4	BCR/ABL	32,39	Crkl	BCR/ABL	12929(Tax:10090)	25	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|leukemogenesis leukemogenesis|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Crkl enhances leukemogenesis in BCR/ABL P190 transgenic_mice .
15982636	0	Crkl	107,111	Bcr/Abl	15,22	Crkl	Bcr/Abl	1399	25	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Bcr/Abl with C3G , an exchange factor for the small GTPase Rap1 , through the adapter protein Crkl .
10608804	0	Crkl	20,24	Cbl	31,34	Crkl	Cbl	12929(Tax:10090)	12402(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration .
7545163	0	Crkl	0,4	Cbl	47,50	Crkl	Cbl	1399	867	Gene	Gene	complexed|nsubjpass|START_ENTITY complexed|nmod|END_ENTITY	Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive_leukemia .
15982636	0	Crkl	107,111	Rap1	73,77	Crkl	Rap1	1399	5906	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|factor factor|nmod|END_ENTITY	Interaction of Bcr/Abl with C3G , an exchange factor for the small GTPase Rap1 , through the adapter protein Crkl .
9845531	0	Crkl	38,42	Thrombopoietin	0,14	Crkl	Thrombopoietin	1399	7066	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets .
11932251	0	Crm1	28,32	Ran-binding_protein_3	0,21	Crm1	Ran-binding protein 3	7514	8498	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Ran-binding_protein_3 links Crm1 to the Ran guanine_nucleotide exchange factor .
8943419	0	Cross-linking_of_intercellular_adhesion_molecule_1	0,50	AP-1	66,70	Cross-linking of intercellular adhesion molecule 1	AP-1	3383	3725	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	Cross-linking_of_intercellular_adhesion_molecule_1 -LRB- CD54 -RRB- induces AP-1 activation and IL-1beta transcription .
20384791	0	Crossveinless-c	0,15	DLC1	60,64	Crossveinless-c	DLC1	41749(Tax:7227)	10395	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Crossveinless-c , the Drosophila homolog of tumor suppressor DLC1 , regulates directional elongation of dendritic branches via down-regulating Rho1 activity .
18539121	0	Crossveinless_2	24,39	BMP	105,108	Crossveinless 2	BMP	45280(Tax:7227)	33432(Tax:7227)	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|END_ENTITY	The BMP-binding protein Crossveinless_2 is a short-range , concentration-dependent , biphasic modulator of BMP signaling in Drosophila .
22474252	0	Crossveinless_2	0,15	bone_morphogenetic_protein_9	26,54	Crossveinless 2	bone morphogenetic protein 9	168667	2658	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Crossveinless_2 regulates bone_morphogenetic_protein_9 in human and mouse vascular endothelium .
20383744	0	CrtR-b2	18,25	carotene_beta_hydroxylase_2	27,54	CrtR-b2	carotene beta hydroxylase 2	544297(Tax:4081)	544297(Tax:4081)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of CrtR-b2 -LRB- carotene_beta_hydroxylase_2 -RRB- from S. _ lycopersicum_L .
10640815	0	Crtl1	73,78	link_protein	54,66	Crtl1	link protein	12950(Tax:10090)	12950(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization and chromosome location of the mouse link_protein gene -LRB- Crtl1 -RRB- .
15851977	0	Crumbs_homolog_2	24,40	CRB2	42,46	Crumbs homolog 2	CRB2	286204	286204	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the Crumbs_homolog_2 -LRB- CRB2 -RRB- gene and analysis of its role in retinitis_pigmentosa and Leber_congenital_amaurosis .
21484995	0	Crumbs_homologue_1	36,54	Crb1	56,60	Crumbs homologue 1	Crb1	23418	23418	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Homozygosity mapping identifies the Crumbs_homologue_1 -LRB- Crb1 -RRB- gene as responsible for a recessive_syndrome of retinitis_pigmentosa and nanophthalmos .
15689355	0	Crx	65,68	Nr2e3	44,49	Crx	Nr2e3	1406	10002	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes .
19020302	0	Cry1	100,104	clock	167,172	Cry1	clock	12952(Tax:10090)	12753(Tax:10090)	Gene	Gene	genes|dep|START_ENTITY analyses|nmod|genes involved|nsubjpass|analyses involved|nmod|process process|nmod|regulation regulation|compound|END_ENTITY	Expression and functional analyses of circadian genes in mouse oocytes and preimplantation embryos : Cry1 is involved in the meiotic process independently of circadian clock regulation .
23319291	0	Cryptic	0,7	GALT	17,21	Cryptic	GALT	55997	2592	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Cryptic residual GALT activity is a potential modifier of scholastic outcome in school age children with classic_galactosemia .
17404228	0	Cryptic	0,7	dihydrolipoamide_dehydrogenase	32,62	Cryptic	dihydrolipoamide dehydrogenase	55997	1738	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Cryptic proteolytic activity of dihydrolipoamide_dehydrogenase .
11523797	0	Crz1	79,83	ENA1	97,101	Crz1	ENA1	855704(Tax:4932)	851610(Tax:4932)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene .
25927423	0	CsA	93,96	IL-6	0,4	CsA	IL-6	1161	3569	Gene	Gene	Family|nmod|START_ENTITY Family|compound|END_ENTITY	IL-6 Family of Cytokines in Crevicular Fluid of Renal Transplant Recipients With and Without CsA - Induced Gingival_Overgrowth .
1465572	0	CsA	25,28	cyclosporin-A	10,23	CsA	cyclosporin-A	1161	1161	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of cyclosporin-A -LRB- CsA -RRB- in saliva in children after oral administration of the drug in mixture or in capsule form .
21885153	0	Csf1r	171,176	colony_stimulating_factor_1_receptor	133,169	Csf1r	colony stimulating factor 1 receptor	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin_alpha_X -LRB- Itgax , CD11c -RRB- and colony_stimulating_factor_1_receptor -LRB- Csf1r , CD115 -RRB- expression fails to discriminate dendritic cells from macrophages .
21071440	0	Csf2	27,31	RelB	15,19	Csf2	RelB	1437	5971	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage_colony-stimulating_factor .
18945591	0	Csf2	71,75	STAT5	15,20	Csf2	STAT5	12981(Tax:10090)	20850(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|compound|END_ENTITY	GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic -LRB- NOD -RRB- mouse myeloid cells .
9281358	0	Csfgm	219,224	colony-stimulating_factor	192,217	Csfgm	colony-stimulating factor	12981(Tax:10090)	12977(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Priming of mouse macrophages with the macrophage colony-stimulating_factor -LRB- CSF-1 -RRB- induces a variety of pathways that regulate expression of the interleukin_6 -LRB- Il6 -RRB- and granulocyte-macrophage colony-stimulating_factor -LRB- Csfgm -RRB- genes .
15277007	0	Csk	41,44	C-terminal_Src_kinase	18,39	Csk	C-terminal Src kinase	12988(Tax:10090)	12988(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of p50 C-terminal_Src_kinase -LRB- Csk -RRB- in mouse testis .
16439366	0	Csk	113,116	C-terminal_Src_kinase	90,111	Csk	C-terminal Src kinase	1445	1445	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase , C-terminal_Src_kinase -LRB- Csk -RRB- .
18268019	0	Csk	48,51	C-terminal_Src_kinase	25,46	Csk	C-terminal Src kinase	1445	1445	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Translational control of C-terminal_Src_kinase -LRB- Csk -RRB- expression by PRL3 phosphatase .
9890993	0	Csk	61,64	C-terminal_Src_kinase	38,59	Csk	C-terminal Src kinase	12988(Tax:10090)	12988(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Adenovirus-mediated overexpression of C-terminal_Src_kinase -LRB- Csk -RRB- in type I astrocytes interferes with cell spreading and attachment to fibronectin .
19874196	0	Csk	19,22	Cbp	0,3	Csk	Cbp	1445	1387	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	Cbp recruitment of Csk into lipid rafts is critical to c-Src_kinase activity and bone resorption in osteoclasts .
16168623	0	Csk	36,39	Csk_homologous_kinase	0,21	Csk	Csk homologous kinase	315707(Tax:10116)	29194(Tax:10116)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Csk_homologous_kinase -LRB- CHK -RRB- , unlike Csk , enhances MAPK activation via Ras-mediated signaling in a Src-independent manner .
9109376	0	Csk	8,11	P19	75,78	Csk	P19	12988(Tax:10090)	83430(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Csk in neural differentiation of the embryonic_carcinoma cell line P19 .
17192274	0	Csk	68,71	PRL3	0,4	Csk	PRL3	1445	11156	Gene	Gene	down-regulation|nmod|START_ENTITY promotes|nmod|down-regulation promotes|nsubj|END_ENTITY	PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation .
18268019	0	Csk	48,51	PRL3	67,71	Csk	PRL3	1445	11156	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Translational control of C-terminal_Src_kinase -LRB- Csk -RRB- expression by PRL3 phosphatase .
17018524	0	Csk	92,95	SRC	0,3	Csk	SRC	1445	6714	Gene	Gene	changes|nmod|START_ENTITY limited|nmod|changes limited|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	SRC tail phosphorylation is limited by structural changes in the regulatory tyrosine kinase Csk .
16002086	0	Csk	49,52	Src	61,64	Csk	Src	1445	6714	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation .
16678999	0	Csk	126,129	Src	61,64	Csk	Src	1445	6714	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of protease-activated_receptor_1-induced Src kinase activity by the association of phosphocaveolin-1 with Csk .
17192274	0	Csk	68,71	Src	83,86	Csk	Src	1445	6714	Gene	Gene	down-regulation|nmod|START_ENTITY promotes|nmod|down-regulation promotes|dep|leading leading|xcomp|END_ENTITY	PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation .
7518562	0	Csk	0,3	Src	19,22	Csk	Src	12988(Tax:10090)	20779(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7518562	0	Csk	0,3	Src	60,63	Csk	Src	12988(Tax:10090)	20779(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY involves|nsubj|suppression involves|nmod|sites sites|nmod|activity activity|compound|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7518562	0	Csk	44,47	Src	19,22	Csk	Src	12988(Tax:10090)	20779(Tax:10090)	Gene	Gene	movement|nmod|START_ENTITY involves|dobj|movement involves|nsubj|suppression suppression|nmod|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7518562	0	Csk	44,47	Src	60,63	Csk	Src	12988(Tax:10090)	20779(Tax:10090)	Gene	Gene	movement|nmod|START_ENTITY involves|dobj|movement involves|nmod|sites sites|nmod|activity activity|compound|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7529760	0	Csk	103,106	Src	14,17	Csk	Src	315707(Tax:10116)	83805(Tax:10116)	Gene	Gene	kinase|appos|START_ENTITY correlation|nmod|kinase Regulation|dep|correlation Regulation|nmod|kinases kinases|compound|END_ENTITY	Regulation of Src family kinases in the developing rat brain : correlation with their regulator kinase , Csk .
8979366	0	Csk	27,30	Src	98,101	Csk	Src	1445	6714	Gene	Gene	C-terminal_Src_kinase|appos|START_ENTITY expressed|nsubjpass|C-terminal_Src_kinase expressed|xcomp|active active|nmod|cells cells|acl:relcl|contain contain|dobj|END_ENTITY	The C-terminal_Src_kinase -LRB- Csk -RRB- is widely expressed , active in HT-29 cells that contain activated Src , and its expression is downregulated in butyrate-treated SW620 cells .
9794236	0	Csk	64,67	Src	23,26	Csk	Src	1445	6714	Gene	Gene	phosphorylation|compound|START_ENTITY blocks|nmod|phosphorylation blocks|nsubj|Autophosphorylation Autophosphorylation|nmod|END_ENTITY	Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation .
16775001	0	Csk	0,3	Src64	29,34	Csk	Src64	41398(Tax:7227)	48973(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells .
24100586	0	Csk	77,80	TCR	49,52	Csk	TCR	12988(Tax:10090)	328483(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45 .
24317039	0	Csk	25,28	TCR	112,115	Csk	TCR	12988(Tax:10090)	328483(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY reveals|nsubj|Inhibition reveals|nmod|initiation initiation|nmod|signaling signaling|compound|END_ENTITY	Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling .
12665526	0	Csk	45,48	T_cell_receptor	87,102	Csk	T cell receptor	1445	6962	Gene	Gene	regulation|nmod|START_ENTITY kinase|nsubj|regulation kinase|dobj|END_ENTITY	Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T_cell_receptor signaling .
15861137	0	Csk	15,18	VE-cadherin	22,33	Csk	VE-cadherin	1445	1003	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Csk to VE-cadherin and inhibition of cell proliferation .
24835103	0	Csk-homologous_kinase	35,56	ErbB2	66,71	Csk-homologous kinase	ErbB2	4145	2064	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Trastuzumab-induced recruitment of Csk-homologous_kinase -LRB- CHK -RRB- to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition .
17999719	0	Csk-homologous_kinase	0,21	SHPS-1	37,43	Csk-homologous kinase	SHPS-1	29194(Tax:10116)	25528(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Csk-homologous_kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells .
15329911	0	Csk_homologous_kinase	27,48	CHK	50,53	Csk homologous kinase	CHK	4145	4145	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of Csk_homologous_kinase -LRB- CHK -RRB- in normal brain and brain_tumors .
15261462	0	Csk_homologous_kinase	26,47	Chk	49,52	Csk homologous kinase	Chk	4145	4145	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Complex regulation of the Csk_homologous_kinase -LRB- Chk -RRB- by IL-4 family cytokines and IFN-gamma in human peripheral blood monocytes .
16168623	0	Csk_homologous_kinase	0,21	Csk	36,39	Csk homologous kinase	Csk	29194(Tax:10116)	315707(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Csk_homologous_kinase -LRB- CHK -RRB- , unlike Csk , enhances MAPK activation via Ras-mediated signaling in a Src-independent manner .
10329710	0	Csk_homologous_kinase	4,25	TrkA	42,46	Csk homologous kinase	TrkA	29194(Tax:10116)	59109(Tax:10116)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	The Csk_homologous_kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells .
9038210	0	Csk_homologous_kinase	22,43	c-KIT	109,114	Csk homologous kinase	c-KIT	4145	3815	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of Csk_homologous_kinase -LRB- CHK -RRB- with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes .
18713466	0	Csrp2	33,38	CRP2	103,107	Csrp2	CRP2	13008(Tax:10090)	13008(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	Targeted disruption of the mouse Csrp2 gene encoding the cysteine - and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure .
10477523	0	CstF-50	77,84	BARD1	43,48	CstF-50	BARD1	1477	580	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50 .
18842000	0	CstF-50	83,90	BARD1	4,9	CstF-50	BARD1	1477	580	Gene	Gene	domain|nmod|START_ENTITY domain|nsubj|C-terminal C-terminal|compound|END_ENTITY	The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50 .
12408968	0	CstF-64	44,51	tauCstF-64	76,86	CstF-64	tauCstF-64	1478	23283	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nsubj|protein	The gene CSTF2T , encoding the human_variant CstF-64 polyadenylation protein tauCstF-64 , lacks introns and may be associated with male sterility .
23291169	0	CtBP1	44,49	AMP-activated_protein_kinase	0,28	CtBP1	AMP-activated protein kinase	1487	5563	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	AMP-activated_protein_kinase phosphorylates CtBP1 and down-regulates its activity .
20818429	0	CtBP1	67,72	Brca1	16,21	CtBP1	Brca1	1487	672	Gene	Gene	transcriptional|nmod|START_ENTITY transcriptional|nsubj|END_ENTITY	Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1 .
21681822	0	CtBP1	59,64	Brca1	35,40	CtBP1	Brca1	1487	672	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast_cancer .
17194444	0	CtBP1	37,42	SLUG	6,10	CtBP1	SLUG	1487	6591	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	Human SLUG does not directly bind to CtBP1 .
25228652	0	CtBP2	0,5	Androgen_Receptor	20,37	CtBP2	Androgen Receptor	1488	367	Gene	Gene	Modulates|nsubj|START_ENTITY Modulates|dobj|END_ENTITY	CtBP2 Modulates the Androgen_Receptor to Promote Prostate_Cancer Progression .
18490918	0	CtBP2	128,133	E1A	89,92	CtBP2	E1A	81717(Tax:10116)	25244(Tax:10116)	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Inhibition of transcriptional activation and cell proliferation activities of adenovirus E1A by the unique N-terminal domain of CtBP2 .
11504872	0	CtBP2	11,16	SOX6	0,4	CtBP2	SOX6	13017(Tax:10090)	20679(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter .
24794430	0	CtIP	13,17	FANCD2	0,6	CtIP	FANCD2	5932	2177	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair .
11751867	0	CtIP	56,60	LMO4	23,27	CtIP	LMO4	5932	8543	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity .
23696749	0	CtIP	30,34	MiR-335	14,21	CtIP	MiR-335	5932	442904	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response .
25267294	0	CtIP	29,33	Polo-like_kinase_3	0,18	CtIP	Polo-like kinase 3	5932	1263	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Polo-like_kinase_3 regulates CtIP during DNA double-strand break repair in G1 .
14654780	0	CtIP	22,26	SIAH-1	0,6	CtIP	SIAH-1	5932	6477	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway .
17112672	0	CtIP	20,24	TRB3	0,4	CtIP	TRB3	5932	57761	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRB3 interacts with CtIP and is overexpressed in certain cancers .
26387952	0	CtIP	49,53	USP4	28,32	CtIP	USP4	5932	7375	Gene	Gene	Cooperates|nmod|START_ENTITY Cooperates|compound|END_ENTITY	The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Break End Resection .
19536159	0	Ctcf	44,48	Oct4	24,28	Ctcf	Oct4	13018(Tax:10090)	18999(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting .
21698197	0	Cten	0,4	Kras	20,24	Cten	Kras	84951	3845	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas .
21339732	0	Cten	0,4	integrin-linked_kinase	21,43	Cten	integrin-linked kinase	84951	3611	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Cten signals through integrin-linked_kinase -LRB- ILK -RRB- and may promote metastasis in colorectal_cancer .
11782448	0	Ctf3p	0,5	Mcm22p	54,60	Ctf3p	Mcm22p	851097(Tax:4932)	853599(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ctf3p , the Mis6 budding yeast homolog , interacts with Mcm22p and Mcm16p at the yeast outer kinetochore .
20381454	0	Ctf4p	0,5	Mcm10p	18,24	Ctf4p	Mcm10p	856254(Tax:4932)	854656(Tax:4932)	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|END_ENTITY	Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast .
25238105	0	Ctla-4	0,6	foxp3	50,55	Ctla-4	foxp3	12477(Tax:10090)	20371(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|differentiation differentiation|nmod|cells cells|amod|END_ENTITY	Ctla-4 modulates the differentiation of inducible foxp3 + treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis .
11867232	0	Ctnnb1	41,47	beta-catenin	22,34	Ctnnb1	beta-catenin	84353(Tax:10116)	84353(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequencing of the rat beta-catenin gene -LRB- Ctnnb1 -RRB- and mutational analysis of liver_tumors induced by 2-amino-3-methylimidazo -LSB- 4,5-f -RSB- quinoline .
14706452	0	Ctnnb1	38,44	beta-catenin	19,31	Ctnnb1	beta-catenin	84353(Tax:10116)	84353(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the rat beta-catenin gene -LRB- Ctnnb1 -RRB- promoter and its functional analysis compared with the Catnb and CTNNB1 promoters .
16365053	0	Ctr1	26,30	Copper_transport_protein	0,24	Ctr1	Copper transport protein	20529(Tax:10090)	20529(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Copper_transport_protein -LRB- Ctr1 -RRB- levels in mice are tissue specific and dependent on copper status .
26048990	0	Ctr9	0,4	Paf1	45,49	Ctr9	Paf1	9646	54623	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Ctr9 , a protein in the transcription complex Paf1 , regulates dopamine_transporter activity at the plasma membrane .
26048990	0	Ctr9	0,4	dopamine_transporter	61,81	Ctr9	dopamine transporter	9646	6531	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Ctr9 , a protein in the transcription complex Paf1 , regulates dopamine_transporter activity at the plasma membrane .
26975390	0	Cts1	128,132	Ace2	25,29	Cts1	Ace2	850992(Tax:4932)	850822(Tax:4932)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	The transcription factor Ace2 and its paralog Swi5 regulate ethanol production during static fermentation through their targets Cts1 and Rps4a in Saccharomyces_cerevisiae .
10065424	0	CtsB	63,67	cathepsin_B	45,56	CtsB	cathepsin B	64529(Tax:10116)	64529(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genome scanning detects amplification of the cathepsin_B gene -LRB- CtsB -RRB- in transformed rat ovarian surface epithelial cells .
1596787	0	Cu-Zn-SOD	53,62	Cu-Zn-superoxide_dismutase	25,51	Cu-Zn-SOD	Cu-Zn-superoxide dismutase	24786(Tax:10116)	24786(Tax:10116)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	-LSB- Immunochemical study of Cu-Zn-superoxide_dismutase -LRB- Cu-Zn-SOD -RRB- in multiple_organ_failure of rats -RSB- .
1596787	0	Cu-Zn-superoxide_dismutase	25,51	Cu-Zn-SOD	53,62	Cu-Zn-superoxide dismutase	Cu-Zn-SOD	24786(Tax:10116)	24786(Tax:10116)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Immunochemical study of Cu-Zn-superoxide_dismutase -LRB- Cu-Zn-SOD -RRB- in multiple_organ_failure of rats -RSB- .
18811921	0	Cu/ZnSOD	56,64	E-SOD	14,19	Cu/ZnSOD	E-SOD	24786(Tax:10116)	25352(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of E-SOD , GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride-treated rats .
7812784	0	CuZn-superoxide_dismutase	0,25	CuZnSOD	27,34	CuZn-superoxide dismutase	CuZnSOD	20655(Tax:10090)	20655(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|appos|END_ENTITY	CuZn-superoxide_dismutase -LRB- CuZnSOD -RRB- transgenic_mice show resistance to the lethal effects of methylenedioxyamphetamine -LRB- MDA -RRB- and of methylenedioxymethamphetamine -LRB- MDMA -RRB- .
7812784	0	CuZnSOD	27,34	CuZn-superoxide_dismutase	0,25	CuZnSOD	CuZn-superoxide dismutase	20655(Tax:10090)	20655(Tax:10090)	Gene	Gene	transgenic_mice|appos|START_ENTITY transgenic_mice|amod|END_ENTITY	CuZn-superoxide_dismutase -LRB- CuZnSOD -RRB- transgenic_mice show resistance to the lethal effects of methylenedioxyamphetamine -LRB- MDA -RRB- and of methylenedioxymethamphetamine -LRB- MDMA -RRB- .
15473258	0	CuZn_superoxide_dismutase	74,99	3-hydroxy-3-methylglutaryl-CoA_reductase	14,54	CuZn superoxide dismutase	3-hydroxy-3-methylglutaryl-CoA reductase	6647	3156	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of 3-hydroxy-3-methylglutaryl-CoA_reductase gene expression by CuZn_superoxide_dismutase in human fibroblasts and HepG2 cells .
20933032	0	CuZn_superoxide_dismutase	77,102	TDP-43	0,6	CuZn superoxide dismutase	TDP-43	6647	23435	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TDP-43 physically interacts with amyotrophic_lateral_sclerosis-linked mutant CuZn_superoxide_dismutase .
26327496	0	Cu_Zn_superoxide_dismutase	23,49	SOD1	51,55	Cu Zn superoxide dismutase	SOD1	6647	6647	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The IFN-b 1b effect on Cu_Zn_superoxide_dismutase -LRB- SOD1 -RRB- in peripheral mononuclear blood cells of relapsing-remitting multiple_sclerosis patients and in neuroblastoma SK-N-BE cells .
23505554	0	Cub_and_Sushi_Multiple_Domains_1	59,91	CSMD1	93,98	Cub and Sushi Multiple Domains 1	CSMD1	64478	64478	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Somatic mutations , allele loss , and DNA methylation of the Cub_and_Sushi_Multiple_Domains_1 -LRB- CSMD1 -RRB- gene reveals association with early age of diagnosis in colorectal_cancer patients .
23592779	0	Cubilin	0,7	fibroblast_growth_factor_8	38,64	Cubilin	fibroblast growth factor 8	65969(Tax:10090)	14179(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Cubilin , a high affinity receptor for fibroblast_growth_factor_8 , is required for cell survival in the developing vertebrate head .
10669739	0	Cubitus_interruptus	0,19	CREB-binding_protein	40,60	Cubitus interruptus	CREB-binding protein	43767(Tax:7227)	43856(Tax:7227)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Cubitus_interruptus requires Drosophila CREB-binding_protein to activate wingless expression in the Drosophila embryo .
17452440	0	Cul4A	25,30	DET1	10,14	Cul4A	DET1	8451	55070	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes .
16467204	0	Cul4A	0,5	p27	14,17	Cul4A	p27	99375(Tax:10090)	22428(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Cul4A targets p27 for degradation and regulates proliferation , cell cycle exit , and differentiation during erythropoiesis .
19917606	0	Cul5	26,30	VACM-1	19,25	cul5	VACM-1	64624(Tax:10116)	64624(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY Phosphorylation|parataxis|regulates Phosphorylation|nmod|END_ENTITY	Phosphorylation of VACM-1 / Cul5 by protein_kinase_A regulates its neddylation and antiproliferative effect .
26544623	0	Cullin3	0,7	BRMS1	99,104	Cullin3	BRMS1	8452	25855	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Cullin3 promotes breast_cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation .
16325183	0	Cullin5	27,34	ASB	0,3	Cullin5	ASB	8065	212	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|proteins proteins|compound|END_ENTITY	ASB proteins interact with Cullin5 and Rbx2 to form E3_ubiquitin_ligase complexes .
22542517	0	Cullin_3	23,31	KBTBD13	0,7	Cullin 3	KBTBD13	8452	390594	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	KBTBD13 interacts with Cullin_3 to form a functional ubiquitin ligase .
26021757	0	Cullin_4A	4,13	E3_Ubiquitin_Ligase	30,49	Cullin 4A	E3 Ubiquitin Ligase	8451	158506	Gene	Gene	START_ENTITY|parataxis|Mediates Mediates|nsubj|END_ENTITY	The Cullin_4A / B-DDB1-Cereblon E3_Ubiquitin_Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels .
26021757	0	Cullin_4A	4,13	E3_Ubiquitin_Ligase	30,49	Cullin 4A	E3 Ubiquitin Ligase	8451	158506	Gene	Gene	START_ENTITY|parataxis|Mediates Mediates|nsubj|END_ENTITY	The Cullin_4A / B-DDB1-Cereblon E3_Ubiquitin_Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels .
25970626	0	Cullin_4B	66,75	DDB1	76,80	Cullin 4B	DDB1	8450	1642	Gene	Gene	Complex|compound|START_ENTITY Complex|compound|END_ENTITY	FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin_4B / DDB1 Complex .
17974915	0	Cullin_5	0,8	Dab1	19,23	Cullin 5	Dab1	8065	1600	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Cullin_5 regulates Dab1 protein levels and neuron positioning during cortical development .
26660891	0	CutC	19,23	hCutC	30,35	CutC	hCutC	51076	51076	Gene	Gene	Gene|compound|START_ENTITY Gene|dep|END_ENTITY	Silencing of Human CutC Gene -LRB- hCutC -RRB- Induces Apoptosis in HepG2 Cells .
11401669	0	Cutaneous_lymphocyte-associated_antigen	0,39	CLA	41,44	Cutaneous lymphocyte-associated antigen	CLA	6404	6404	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cutaneous_lymphocyte-associated_antigen -LRB- CLA -RRB- expression in a lymphoblastoid_mantle_cell_lymphoma presenting with skin_lesions .
19665434	0	Cutaneous_lymphocyte-associated_antigen	0,39	CLA	41,44	Cutaneous lymphocyte-associated antigen	CLA	6404	6404	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Cutaneous_lymphocyte-associated_antigen -LRB- CLA -RRB- T cells up-regulate P-selectin ligand expression upon their activation .
11584018	0	Cux	56,59	CDP	51,54	Cux	CDP	1523	1523	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Phosphorylation of the CCAAT_displacement_protein -LRB- CDP -RRB- / Cux transcription factor by cyclin_A-Cdk1 modulates its DNA binding activity in G -LRB- 2 -RRB- .
11969263	0	Cux-1	44,49	p27	98,101	Cux-1	p27	13047(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	Deregulated expression of the homeobox gene Cux-1 in transgenic_mice results in downregulation of p27 -LRB- kip1 -RRB- expression during nephrogenesis , glomerular_abnormalities , and multiorgan hyperplasia .
7910552	0	Cux/CDP	85,92	Phox2	30,35	Cux/CDP	Phox2	13047(Tax:10090)	11859(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype .
19332113	0	Cux1	24,28	Grg4	44,48	Cux1	Grg4	1523	7091	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The homeodomain protein Cux1 interacts with Grg4 to repress p27_kip1 expression during kidney development .
21465620	0	Cux1	22,26	p27	54,57	Cux1	p27	13047(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|amod|END_ENTITY	Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts .
9335271	0	CvaA	86,90	CvaB	155,159	CvaA	CvaB	5962109(Tax:562)	3853540(Tax:562)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Interactions of dedicated export membrane proteins of the colicin V secretion system : CvaA , a member of the membrane fusion protein family , interacts with CvaB and TolC .
9335271	0	CvaB	155,159	CvaA	86,90	CvaB	CvaA	3853540(Tax:562)	5962109(Tax:562)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Interactions of dedicated export membrane proteins of the colicin V secretion system : CvaA , a member of the membrane fusion protein family , interacts with CvaB and TolC .
19789211	0	Cwc21	33,38	SRm300	93,99	Cwc21	SRm300	23524	23524	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	A systematic characterization of Cwc21 , the yeast ortholog of the human spliceosomal protein SRm300 .
15798904	0	Cx26	18,22	CO2	50,53	Cx26	CO2	2706	717	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Opposite Cx32 and Cx26 voltage-gating response to CO2 reflects opposite voltage-gating polarity .
15253766	0	Cx26	51,55	GJB2	45,49	Cx26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Spectrum and frequencies of mutations in the GJB2 -LRB- Cx26 -RRB- gene among 156 Czech patients with pre-lingual_deafness .
19027181	0	Cx26	36,40	GJB2	25,29	Cx26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular studies in the GJB2 gene -LRB- Cx26 -RRB- among a deaf population from Bogot , Colombia : results of a screening program .
22172221	0	Cx26	18,22	GJB2	12,16	Cx26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Spectrum of GJB2 -LRB- Cx26 -RRB- gene mutations in Iranian Azeri patients with nonsyndromic autosomal recessive hearing_loss .
22649694	0	Cx26	113,117	GJB2	107,111	Cx26	GJB2	2706	2706	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Haplotype Diversity and Reconstruction of Ancestral Haplotype Associated with the c. 35delG Mutation in the GJB2 -LRB- Cx26 -RRB- Gene among the Volgo-Ural Populations of Russia .
15140211	0	Cx30	59,63	GJB6	70,74	Cx30	GJB6	10804	10804	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Genetic heterogeneity of KID_syndrome : identification of a Cx30 gene -LRB- GJB6 -RRB- mutation in a patient with KID_syndrome and congenital atrichia .
15350541	0	Cx32	33,37	IL-1beta	0,8	Cx32	IL-1beta	29584(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-1beta regulates expression of Cx32 , occludin , and claudin-2 of rat hepatocytes via distinct signal transduction pathways .
22389404	0	Cx43	27,31	CASK	0,4	Cx43	CASK	2697	8573	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CASK -LRB- LIN2 -RRB- interacts with Cx43 in wounded skin and their coexpression affects cell migration .
18687515	0	Cx43	30,34	Connexin_43	17,28	Cx43	Connexin 43	2697	2697	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A pilot study of Connexin_43 -LRB- Cx43 -RRB- in human bladder tissue in patients with idiopathic_detrusor_overactivity .
26748803	0	Cx43	13,17	Connexin_43	0,11	Cx43	Connexin 43	2697	2697	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Connexin_43 -LRB- Cx43 -RRB- Expression in Laryngeal_Squamous_Cell_Carcinomas : Preliminary Data on Its Possible Prognostic Role .
19835873	0	Cx43	35,39	Eps15	0,5	Cx43	Eps15	2697	2060	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Eps15 interacts with ubiquitinated Cx43 and mediates its internalization .
21538160	0	Cx43	74,78	Sox4	0,4	Cx43	Sox4	30236(Tax:7955)	336346(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43 .
18406048	0	Cx43	19,23	TGF-beta1	0,9	Cx43	TGF-beta1	2697	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits Cx43 expression and formation of functional syncytia in cultured smooth muscle cells from human detrusor .
21538160	0	Cx43	74,78	Tbx3	14,18	Cx43	Tbx3	30236(Tax:7955)	556870(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43 .
22325386	0	Cx43	48,52	connexin_43	35,46	Cx43	connexin 43	24392(Tax:10116)	24392(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prenatal retinoic_acid upregulates connexin_43 -LRB- Cx43 -RRB- gene expression in pulmonary_hypoplasia in the nitrofen-induced congenital_diaphragmatic_hernia rat model .
23685568	0	Cx43	113,117	connexin_43	100,111	Cx43	connexin 43	2697	2697	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Short-term cultivation of porcine cumulus cells influences the cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- and connexin_43 -LRB- Cx43 -RRB- protein expression -- a real-time cell proliferation approach .
26481195	0	Cx43	15,19	p27	79,82	Cx43	p27	2697	3429	Gene	Gene	Interaction|nmod|START_ENTITY regulates|nsubj|Interaction regulates|nmod|END_ENTITY	Interaction of Cx43 with Hsc70 regulates G1/S transition through CDK inhibitor p27 .
21254920	0	Cx45	32,36	GJA7	26,30	Cx45	GJA7	10052	10052	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation screening of the GJA7 -LRB- Cx45 -RRB- gene in a large international series of probands with nonsyndromic_hearing_impairment .
15183511	0	Cx47	76,80	zonula_occludens-1	98,116	Cx47	zonula occludens-1	118454(Tax:10090)	21872(Tax:10090)	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Connexin47 , connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula_occludens-1 -LRB- ZO-1 -RRB- in mouse brain .
11875045	0	Cx50	8,12	Gja8	2,6	Cx50	Gja8	14616(Tax:10090)	14616(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	A Gja8 -LRB- Cx50 -RRB- point mutation causes an alteration of alpha_3_connexin -LRB- Cx46 -RRB- in semi-dominant cataracts of Lop10 mice .
9746435	0	Cx50	31,35	connexin_50	18,29	Cx50	connexin 50	14616(Tax:10090)	14616(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A mutation in the connexin_50 -LRB- Cx50 -RRB- gene is a candidate for the No2 mouse cataract .
7796604	0	Cx50	48,52	lens_intrinsic_membrane_protein_MP70	10,46	Cx50	lens intrinsic membrane protein MP70	2703	2703	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human lens_intrinsic_membrane_protein_MP70 -LRB- Cx50 -RRB- gene : clonal analysis and chromosome mapping .
19147675	0	Cxcl1	14,19	parathyroid_hormone	46,65	Cxcl1	parathyroid hormone	81503(Tax:10116)	24694(Tax:10116)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	The chemokine Cxcl1 is a novel target gene of parathyroid_hormone -LRB- PTH -RRB- / PTH-related protein in committed osteoblasts .
24398292	0	Cxcl11	31,37	I-TAC	24,29	Cxcl11	I-TAC	56066(Tax:10090)	56066(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Epidermal expression of I-TAC -LRB- Cxcl11 -RRB- instructs adaptive Th2-type immunity .
17374609	0	Cxcl12	4,10	early_B-cell_factor	61,80	Cxcl12	early B-cell factor	20315(Tax:10090)	13591(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	The Cxcl12 , periostin , and Ccl9 genes are direct targets for early_B-cell_factor in OP-9 stroma cells .
22326959	0	Cxcr2	0,5	IL-17	29,34	Cxcr2	IL-17	12765(Tax:10090)	16171(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Cxcr2 and Cxcl5 regulate the IL-17 / G-CSF axis and neutrophil homeostasis in mice .
22978573	0	Cxcr4	77,82	CXCL12	7,13	Cxcr4	CXCL12	7852	6387	Gene	Gene	mobilisation|nmod|START_ENTITY regeneration|nmod|mobilisation expressing|nsubj|regeneration improves|dep|expressing improves|nsubj|Sdf-1 Sdf-1|appos|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- improves skeletal muscle regeneration via the mobilisation of Cxcr4 and CD34 expressing cells .
22978573	0	Cxcr4	77,82	Sdf-1	0,5	Cxcr4	Sdf-1	7852	6387	Gene	Gene	mobilisation|nmod|START_ENTITY regeneration|nmod|mobilisation expressing|nsubj|regeneration improves|dep|expressing improves|nsubj|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- improves skeletal muscle regeneration via the mobilisation of Cxcr4 and CD34 expressing cells .
8621687	0	CyP-40	100,106	FKBP52	79,85	CyP-40	FKBP52	5481	2288	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Cyclophilin_40 -LRB- CyP-40 -RRB- , mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding .
19744714	0	Cybr	8,12	cytohesin_binder_and_regulator	16,46	Cybr	cytohesin binder and regulator	227929(Tax:10090)	227929(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Cybr , a cytohesin_binder_and_regulator , in CD4 -LRB- + -RRB- T-cell function and host immunity .
8943325	0	Cyc8	4,8	Tup1	16,20	Cyc8	Tup1	852410(Tax:4932)	850445(Tax:4932)	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	The Cyc8 -LRB- Ssn6 -RRB- - Tup1 corepressor complex is composed of one Cyc8 and four Tup1 subunits .
25480791	0	Cyclic_GMP_Kinase_II	0,20	NHE3	38,42	Cyclic GMP Kinase II	NHE3	19092(Tax:10090)	105243(Tax:10090)	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|END_ENTITY	Cyclic_GMP_Kinase_II -LRB- cGKII -RRB- Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites : IDENTIFICATION OF A MULTIFUNCTIONAL PHOSPHORYLATION SITE .
16819137	0	Cyclic_nucleotide_Response_Element_Binding_protein	0,50	CREB	52,56	Cyclic nucleotide Response Element Binding protein	CREB	1385	1385	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Cyclic_nucleotide_Response_Element_Binding_protein -LRB- CREB -RRB- activation promotes survival signal in human K562 erythroleukemia cells exposed to ionising radiation/etoposide combined treatment .
9192873	0	Cyclin	0,6	p27Kip1	32,39	Cyclin	p27Kip1	18538(Tax:10090)	12576(Tax:10090)	Gene	Gene	E-CDK2|compound|START_ENTITY regulator|nsubj|E-CDK2 regulator|nmod|END_ENTITY	Cyclin E-CDK2 is a regulator of p27Kip1 .
2147872	0	Cyclin	0,6	p34cdc2	21,28	Cyclin	p34cdc2	394328(Tax:8355)	380246(Tax:8355)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Cyclin activation of p34cdc2 .
11570573	0	Cyclin	0,6	pRB	54,57	Cyclin	pRB	5111	5925	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclin D1 expression and retinoblastoma gene protein -LRB- pRB -RRB- expression in esophageal_squamous_cell_carcinoma .
21040761	0	Cyclin-D1	95,104	MEK	11,14	Cyclin-D1	MEK	595	5609	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of MEK and DNMT inhibitors on arsenic-treated human uroepithelial cells in relation to Cyclin-D1 and p16 .
26344141	0	Cyclin-Dependent_Kinase_Inhibitor_1B	29,65	p27	67,70	Cyclin-Dependent Kinase Inhibitor 1B	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	SGK1-Sensitive Regulation of Cyclin-Dependent_Kinase_Inhibitor_1B -LRB- p27 -RRB- in Cardiomyocyte Hypertrophy .
18977197	0	Cyclin-dependent_kinase-like_5	0,30	DNA_methyltransferase_1	56,79	Cyclin-dependent kinase-like 5	DNA methyltransferase 1	382253(Tax:10090)	13433(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Cyclin-dependent_kinase-like_5 binds and phosphorylates DNA_methyltransferase_1 .
21659531	0	Cyclin-dependent_kinase_1	0,25	Ezh2	82,86	Cyclin-dependent kinase 1	Ezh2	983	2146	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- - mediated phosphorylation of enhancer_of_zeste_2 -LRB- Ezh2 -RRB- regulates its stability .
15963510	0	Cyclin-dependent_kinase_11	0,26	HBO1	47,51	Cyclin-dependent kinase 11	HBO1	23097	11143	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cyclin-dependent_kinase_11 -LRB- p58 -RRB- interacts with HBO1 and enhances its histone acetyltransferase activity .
20216405	0	Cyclin-dependent_kinase_2	0,25	CDK-2	27,32	Cyclin-dependent kinase 2	CDK-2	1017	1017	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclin-dependent_kinase_2 -LRB- CDK-2 -RRB- expression in nonmelanocytic human cutaneous lesions .
18784074	0	Cyclin-dependent_kinase_2	0,25	CYP3A4	82,88	Cyclin-dependent kinase 2	CYP3A4	1017	1576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Cyclin-dependent_kinase_2 negatively regulates human pregnane_X_receptor-mediated CYP3A4 gene expression in HepG2 liver_carcinoma cells .
15063782	0	Cyclin-dependent_kinase_2	0,25	beta-catenin	65,77	Cyclin-dependent kinase 2	beta-catenin	1017	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Cyclin-dependent_kinase_2 regulates the interaction of Axin with beta-catenin .
26198700	0	Cyclin-dependent_kinase_5	0,25	Foxp3	36,41	Cyclin-dependent kinase 5	Foxp3	12568(Tax:10090)	20371(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Cyclin-dependent_kinase_5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727 .
23077056	0	Cyclin-dependent_kinase_5	0,25	KIF13B	110,116	Cyclin-dependent kinase 5	KIF13B	1020	23303	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Cyclin-dependent_kinase_5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B .
18385322	0	Cyclin-dependent_kinase_5	0,25	SEPT5	58,63	Cyclin-dependent kinase 5	SEPT5	1020	5413	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cyclin-dependent_kinase_5 phosphorylation of human septin SEPT5 -LRB- hCDCrel-1 -RRB- modulates exocytosis .
23941877	0	Cyclin-dependent_kinase_5	0,25	STAT3	117,122	Cyclin-dependent kinase 5	STAT3	1020	6774	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Cyclin-dependent_kinase_5 modulates STAT3 and androgen_receptor activation through phosphorylation of Ser on STAT3 in prostate_cancer cells .
23941877	0	Cyclin-dependent_kinase_5	0,25	STAT3	36,41	Cyclin-dependent kinase 5	STAT3	1020	6774	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activation activation|compound|END_ENTITY	Cyclin-dependent_kinase_5 modulates STAT3 and androgen_receptor activation through phosphorylation of Ser on STAT3 in prostate_cancer cells .
26198700	0	Cyclin-dependent_kinase_5	0,25	Stat3	115,120	Cyclin-dependent kinase 5	Stat3	12568(Tax:10090)	20848(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Cyclin-dependent_kinase_5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727 .
11813240	0	Cyclin-dependent_kinase_5	0,25	cdk5	27,31	Cyclin-dependent kinase 5	cdk5	1020	1020	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activation requires interaction with three domains of p35 .
11813240	0	Cyclin-dependent_kinase_5	0,25	p35	87,90	Cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activation|amod|START_ENTITY requires|nsubj|activation requires|nmod|domains domains|nmod|END_ENTITY	Cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activation requires interaction with three domains of p35 .
12019323	0	Cyclin-dependent_kinase_5	0,25	p35	26,29	Cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 / p35 contributes synergistically with Reelin/Dab1 to the positioning of facial_branchiomotor_and_inferior_olive_neurons in the developing mouse hindbrain .
15908038	0	Cyclin-dependent_kinase_5	0,25	p35	37,40	Cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activators|amod|START_ENTITY activators|amod|END_ENTITY	Cyclin-dependent_kinase_5 activators p35 and p39 facilitate formation of functional synapses .
19362124	0	Cyclin-dependent_kinase_5	0,25	p35	36,39	Cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activator|nsubj|START_ENTITY activator|dobj|over-expression over-expression|amod|END_ENTITY	Cyclin-dependent_kinase_5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells .
15096606	0	Cyclin-dependent_kinase_5	0,25	signal_transducer_and_activator_of_transcription_3	41,91	Cyclin-dependent kinase 5	signal transducer and activator of transcription 3	12568(Tax:10090)	20848(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Cyclin-dependent_kinase_5 phosphorylates signal_transducer_and_activator_of_transcription_3 and regulates its transcriptional activity .
18293492	0	CyclinD1	96,104	CIAPIN1	0,7	CyclinD1	CIAPIN1	595	57019	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	CIAPIN1 inhibits gastric_cancer cell proliferation and cell cycle progression by downregulating CyclinD1 and upregulating P27 .
18787961	0	CyclinD1	18,26	p16	50,53	CyclinD1	p16	595	1029	Gene	Gene	START_ENTITY|nmod|correlate correlate|amod|END_ENTITY	Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node metastases in laryngeal_squamous_cell_carcinoma in Chinese patients .
25647033	0	CyclinD2	123,131	MiR-204	0,7	CyclinD2	MiR-204	894	406987	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-204 , down-regulated in retinoblastoma , regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9 .
20008573	0	CyclinE	52,59	Osa	33,36	CyclinE	Osa	34924(Tax:7227)	42130(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs .
10626899	0	Cyclin_A	0,8	CDK2	9,13	Cyclin A	CDK2	890	1017	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Cyclin_A / CDK2 regulates V -LRB- D -RRB- J recombination by coordinating RAG-2 accumulation and DNA repair .
25736292	0	Cyclin_A	0,8	CDK2	9,13	Cyclin A	CDK2	890	1017	Gene	Gene	START_ENTITY|parataxis|replisome replisome|nsubj|phosphorylation phosphorylation|nummod|END_ENTITY	Cyclin_A / CDK2 phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication .
7969176	0	Cyclin_A	0,8	CDK2	9,13	Cyclin A	CDK2	890	1017	Gene	Gene	START_ENTITY|parataxis|binds binds|nsubj|END_ENTITY	Cyclin_A / CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1 / DP-1 by phosphorylation .
22465120	0	Cyclin_A	0,8	CKAP2	56,61	Cyclin A	CKAP2	890	26586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Cyclin_A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1 .
14767478	0	Cyclin_A	0,8	Cdk2	9,13	Cyclin A	Cdk2	890	1017	Gene	Gene	START_ENTITY|parataxis|regulate regulate|nsubj|complexes complexes|amod|END_ENTITY	Cyclin_A / Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells .
25485510	0	Cyclin_A	0,8	Cdk2	9,13	Cyclin A	Cdk2	890	1017	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Cyclin_A / Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle .
10792046	0	Cyclin_A	0,8	DNA_polymerase_delta	23,43	Cyclin A	DNA polymerase delta	890	5424	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cyclin_A activates the DNA_polymerase_delta - dependent elongation machinery in vitro : A parvovirus DNA replication model .
11549444	0	Cyclin_A	24,32	E2F-1	18,23	Cyclin A	E2F-1	890	1869	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Identification of E2F-1 / Cyclin_A antagonists .
25750333	0	Cyclin_A	0,8	YB1	25,28	Cyclin A	YB1	890	4904	Gene	Gene	Correlates|compound|START_ENTITY Correlates|nmod|END_ENTITY	Cyclin_A Correlates with YB1 , Progression and Resistance to Chemotherapy in Human Epithelial Ovarian Cancer .
18372919	0	Cyclin_A	0,8	cdk2	9,13	Cyclin A	cdk2	890	1017	Gene	Gene	START_ENTITY|parataxis|coordinates coordinates|nsubj|END_ENTITY	Cyclin_A / cdk2 coordinates centrosomal and nuclear mitotic events .
19703905	0	Cyclin_A	0,8	cdk2	9,13	Cyclin A	cdk2	890	1017	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Cyclin_A / cdk2 regulates adenomatous_polyposis_coli-dependent mitotic spindle anchoring .
15557231	0	Cyclin_A	0,8	p27	67,70	Cyclin A	p27	890	3429	Gene	Gene	expression|compound|START_ENTITY uncoupled|nsubjpass|expression uncoupled|nmod|deregulation deregulation|amod|END_ENTITY	Cyclin_A expression and growth in suspension can be uncoupled from p27 deregulation and extracellular signal-regulated kinase activity in cells transformed by bovine_papillomavirus_type_4 E5 .
1297652	0	Cyclin_A	0,8	p33cdk2	18,25	Cyclin A	p33cdk2	890	1017	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Cyclin_A recruits p33cdk2 to the cellular transcription factor DRTF1 .
9000053	0	Cyclin_A	63,71	rca1	48,52	Cyclin A	rca1	39340(Tax:7227)	33959(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Control of G1 in the developing Drosophila eye : rca1 regulates Cyclin_A .
24002705	0	Cyclin_A1	0,9	PITX2	41,46	Cyclin A1	PITX2	8900	5308	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cyclin_A1 is a transcriptional target of PITX2 and overexpressed in papillary_thyroid_carcinoma .
19082485	0	Cyclin_A1	0,9	WT1	20,23	Cyclin A1	WT1	8900	7490	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Cyclin_A1 regulates WT1 expression in acute_myeloid_leukemia cells .
23991063	0	Cyclin_A1	0,9	vascular_endothelial_growth_factor	38,72	Cyclin A1	vascular endothelial growth factor	8900	7422	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Cyclin_A1 modulates the expression of vascular_endothelial_growth_factor and promotes hormone-dependent growth and angiogenesis of breast_cancer .
19028417	0	Cyclin_B1	24,33	Aurora-A	0,8	Cyclin B1	Aurora-A	891	6790	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Aurora-A interacts with Cyclin_B1 and enhances its stability .
22071694	0	Cyclin_B1	0,9	Bim	46,49	Cyclin B1	Bim	891	10018	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cyclin_B1 interacts with the BH3-only protein Bim and mediates its phosphorylation by Cdk1 during mitosis .
17408621	0	Cyclin_B1	0,9	Cdk1	10,14	Cyclin B1	Cdk1	891	983	Gene	Gene	START_ENTITY|parataxis|binds binds|nsubj|END_ENTITY	Cyclin_B1 / Cdk1 binds and phosphorylates Filamin_A and regulates its ability to cross-link actin .
24746669	0	Cyclin_B1	0,9	Cdk1	10,14	Cyclin B1	Cdk1	891	983	Gene	Gene	START_ENTITY|parataxis|coordinates coordinates|nsubj|END_ENTITY	Cyclin_B1 / Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression .
15548709	0	Cyclin_B1	0,9	RhoB	34,38	Cyclin B1	RhoB	268697(Tax:10090)	11852(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cyclin_B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition .
20808790	0	Cyclin_B1	0,9	p53	48,51	Cyclin B1	p53	891	7157	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Cyclin_B1 / Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response .
8700522	0	Cyclin_C	0,8	CDK8	9,13	Cyclin C	CDK8	892	1024	Gene	Gene	START_ENTITY|parataxis|kinase kinase|nsubj|END_ENTITY	Cyclin_C / CDK8 is a novel CTD kinase associated with RNA polymerase II .
15084261	0	Cyclin_C	0,8	cdk3	9,13	Cyclin C	cdk3	892	1018	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Cyclin_C / cdk3 promotes Rb-dependent G0 exit .
16405968	0	Cyclin_D1	0,9	ATF-2	29,34	Cyclin D1	ATF-2	12443(Tax:10090)	11909(Tax:10090)	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Cyclin_D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration .
23813870	0	Cyclin_D1	152,161	Akt	14,17	Cyclin D1	Akt	12443(Tax:10090)	11651(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY keratinocytes|nmod|modulation proliferation|nmod|keratinocytes role|nmod|proliferation play|dobj|role play|nsubj|END_ENTITY	EGFR-mediated Akt and MAPKs signal pathways play a crucial role in patulin-induced cell proliferation in primary murine keratinocytes via modulation of Cyclin_D1 and COX-2 expression .
26387543	0	Cyclin_D1	0,9	BRCA2	79,84	Cyclin D1	BRCA2	595	675	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|restricting restricting|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Cyclin_D1 promotes BRCA2-Rad51 interaction by restricting cyclin_A / B-dependent BRCA2 phosphorylation .
12955092	0	Cyclin_D1	0,9	CCND1	16,21	Cyclin D1	CCND1	595	595	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cyclin_D1 gene -LRB- CCND1 -RRB- mutations in endometrial_cancer .
16258756	0	Cyclin_D1	0,9	CCND1	16,21	Cyclin D1	CCND1	595	595	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cyclin_D1 gene -LRB- CCND1 -RRB- polymorphism and the risk of squamous_cell_carcinoma of the larynx .
23060014	0	Cyclin_D1	0,9	CCND1	11,16	Cyclin D1	CCND1	595	595	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclin_D1 -LRB- CCND1 -RRB- expression is involved in estrogen receptor beta -LRB- ERb -RRB- in human prostate_cancer .
24060591	0	Cyclin_D1	0,9	CCND1	11,16	Cyclin D1	CCND1	595	595	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Cyclin_D1 -LRB- CCND1 -RRB- messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle_cell_lymphoma .
26979757	0	Cyclin_D1	51,60	CCND1	67,72	Cyclin D1	CCND1	595	595	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association Between Polymorphism rs678653 in Human Cyclin_D1 Gene -LRB- CCND1 -RRB- and Susceptibility to Cancer : A Meta-Analysis .
23333330	0	Cyclin_D1	0,9	Cdk4	10,14	Cyclin D1	Cdk4	595	1019	Gene	Gene	START_ENTITY|parataxis|increases increases|nsubj|END_ENTITY	Cyclin_D1 / Cdk4 increases the transcriptional activity of FOXM1c without phosphorylating FOXM1c .
8058330	0	Cyclin_D1	131,140	Cdk4	110,114	Cyclin D1	Cdk4	595	1019	Gene	Gene	function|amod|START_ENTITY required|nmod|function required|nsubjpass|expression expression|nmod|protein protein|dep|association association|nmod|END_ENTITY	Differential expression and regulation of Cyclin_D1 protein in normal and tumor human cells : association with Cdk4 is required for Cyclin_D1 function in G1 progression .
8058330	0	Cyclin_D1	42,51	Cdk4	110,114	Cyclin D1	Cdk4	595	1019	Gene	Gene	protein|amod|START_ENTITY protein|dep|association association|nmod|END_ENTITY	Differential expression and regulation of Cyclin_D1 protein in normal and tumor human cells : association with Cdk4 is required for Cyclin_D1 function in G1 progression .
9190208	0	Cyclin_D1	0,9	Cdk4	10,14	Cyclin D1	Cdk4	595	1019	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Cyclin_D1 / Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation .
24287487	0	Cyclin_D1	0,9	Dicer	23,28	Cyclin D1	Dicer	595	23405	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Cyclin_D1 induction of Dicer governs microRNA processing and expression in breast_cancer .
20154722	0	Cyclin_D1	0,9	GATA3	48,53	Cyclin D1	GATA3	595	2625	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cyclin_D1 is a direct transcriptional target of GATA3 in neuroblastoma_tumor cells .
16230390	0	Cyclin_D1	0,9	IkappaB_kinase_beta	28,47	Cyclin D1	IkappaB kinase beta	595	16150(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Cyclin_D1 induction through IkappaB_kinase_beta / nuclear_factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes .
19933579	0	Cyclin_D1	0,9	NFATc1	40,46	Cyclin D1	NFATc1	595	4772	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Cyclin_D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling .
10611246	0	Cyclin_D1	0,9	Neu	54,57	Cyclin D1	Neu	595	2064	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Cyclin_D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway .
8626826	0	Cyclin_D1	0,9	PRAD1	10,15	Cyclin D1	PRAD1	595	595	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Cyclin_D1 / PRAD1 expression in parathyroid_adenomas : an immunohistochemical study .
9065811	0	Cyclin_D1	0,9	PRAD1	11,16	Cyclin D1	PRAD1	595	595	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Cyclin_D1 -LRB- PRAD1 -RRB- alternative transcript b : full-length cDNA cloning and expression in breast_cancers .
22393466	0	Cyclin_D1	47,56	Pdcd4	18,23	Cyclin D1	Pdcd4	595	27250	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin_D1 Expression and Promotes Cell Proliferation .
12792768	0	Cyclin_D1	92,101	Pin1	71,75	Cyclin D1	Pin1	595	5300	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|amod|END_ENTITY	Expression status of Pin1 and cyclins in oral_squamous_cell_carcinoma : Pin1 correlates with Cyclin_D1 mRNA expression and clinical significance of cyclins .
22801439	0	Cyclin_D1	15,24	Slug	0,4	Cyclin D1	Slug	595	6591	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Slug regulates Cyclin_D1 expression by ubiquitin-proteasome pathway in prostate_cancer cells .
11126356	0	Cyclin_D1	0,9	TAFII250	67,75	Cyclin D1	TAFII250	595	6872	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Cyclin_D1 suppresses_retinoblastoma protein-mediated inhibition of TAFII250 kinase activity .
16702957	0	Cyclin_D1	26,35	Tristetraprolin	0,15	Cyclin D1	Tristetraprolin	595	7538	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Tristetraprolin regulates Cyclin_D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling .
11328859	0	Cyclin_D1	0,9	androgen_receptor	20,37	Cyclin D1	androgen receptor	595	367	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Cyclin_D1 binds the androgen_receptor and regulates hormone-dependent signaling in a p300/CBP-associated _ factor -LRB- P/CAF -RRB- - dependent manner .
11714699	0	Cyclin_D1	0,9	androgen_receptor	40,57	Cyclin D1	androgen receptor	595	367	Gene	Gene	START_ENTITY|dep|mechanism mechanism|nmod|activity activity|compound|END_ENTITY	Cyclin_D1 : mechanism and consequence of androgen_receptor co-repressor activity .
15539430	0	Cyclin_D1	0,9	androgen_receptor	25,42	Cyclin D1	androgen receptor	595	367	Gene	Gene	binding|advmod|START_ENTITY binding|nmod|END_ENTITY	Cyclin_D1 binding to the androgen_receptor -LRB- AR -RRB- NH2-terminal domain inhibits activation function 2 association and reveals dual roles for AR corepression .
23066445	0	Cyclin_D1	14,23	b-Catenin	43,52	Cyclin D1	b-Catenin	595	1499	Gene	Gene	Expression|nmod|START_ENTITY Associated|nsubj|Expression Associated|nmod|Expression Expression|amod|END_ENTITY	Expression of Cyclin_D1 Is Associated with b-Catenin Expression and Correlates with Good Prognosis in Colorectal_Adenocarcinoma .
18605443	0	Cyclin_D1	166,175	basic_fibroblast_growth_factor	12,42	Cyclin D1	basic fibroblast growth factor	595	2247	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of basic_fibroblast_growth_factor on the proliferation of human salivary adenoid_cystic_carcinoma cell line ACC-2 and extracellular_signal-regulated_kinase , Cyclin_D1 , p2waf/cip1 signaling pathway -RSB- .
12081197	0	Cyclin_D1	0,9	beta-catenin	73,85	Cyclin D1	beta-catenin	595	1499	Gene	Gene	overexpression|amod|START_ENTITY dependent|nsubj|overexpression dependent|nmod|dysregulation dysregulation|amod|END_ENTITY	Cyclin_D1 overexpression in colorectal_carcinoma in vivo is dependent on beta-catenin protein dysregulation , but not k-ras mutation .
12183406	0	Cyclin_D1	0,9	beta-catenin	40,52	Cyclin D1	beta-catenin	12443(Tax:10090)	12387(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cyclin_D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis , but it may act as a modifier of disease severity in multiple_intestinal_neoplasia -LRB- Min -RRB- mice .
12663502	0	Cyclin_D1	0,9	beta-catenin	42,54	Cyclin D1	beta-catenin	12443(Tax:10090)	12387(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Cyclin_D1 over-expression correlates with beta-catenin activation , but not with H-ras mutations , and phosphorylation of Akt , GSK3_beta and ERK1/2 in mouse hepatic_carcinogenesis .
15946945	0	Cyclin_D1	0,9	beta-catenin	40,52	Cyclin D1	beta-catenin	12443(Tax:10090)	12387(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|Apc_loss Apc_loss|amod|END_ENTITY	Cyclin_D1 is not an immediate target of beta-catenin following Apc_loss in the intestine .
12970790	0	Cyclin_D1	117,126	cannabinoid_receptor_1	14,36	Cyclin D1	cannabinoid receptor 1	595	1268	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	High level of cannabinoid_receptor_1 , absence of regulator_of_G_protein_signalling_13 and differential expression of Cyclin_D1 in mantle_cell_lymphoma .
17894419	0	Cyclin_D1	0,9	cdk4	10,14	Cyclin D1	cdk4	595	1019	Gene	Gene	START_ENTITY|parataxis|interact interact|nsubj|END_ENTITY	Cyclin_D1 / cdk4 can interact with E2F4/DP1 and disrupts its DNA-binding capacity .
7739541	0	Cyclin_D1	0,9	cdk4	96,100	Cyclin D1	cdk4	595	1019	Gene	Gene	dispensable|nsubj|START_ENTITY dispensable|nmod|activity activity|amod|END_ENTITY	Cyclin_D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity .
9271411	0	Cyclin_D1	0,9	cdk4	83,87	Cyclin D1	cdk4	595	1019	Gene	Gene	stimulation|amod|START_ENTITY transcriptional|nsubj|stimulation transcriptional|dobj|activity activity|nmod|END_ENTITY	Cyclin_D1 stimulation of estrogen_receptor transcriptional activity independent of cdk4 .
26387543	0	Cyclin_D1	0,9	cyclin_A	58,66	Cyclin D1	cyclin A	595	890	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|restricting restricting|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Cyclin_D1 promotes BRCA2-Rad51 interaction by restricting cyclin_A / B-dependent BRCA2 phosphorylation .
9271411	0	Cyclin_D1	0,9	estrogen_receptor	25,42	Cyclin D1	estrogen receptor	595	2099	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Cyclin_D1 stimulation of estrogen_receptor transcriptional activity independent of cdk4 .
21867613	0	Cyclin_D1	1,10	hTERT	12,17	Cyclin D1	hTERT	595	7015	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	-LSB- Cyclin_D1 , hTERT expression and telomerase activity in HL-60 and HL-60A cell lines and their significance -RSB- .
25985117	0	Cyclin_D1	121,130	microRNA-19a	108,120	Cyclin D1	microRNA-19a	595	406979	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	A systematic investigation based on microRNA-mediated gene regulatory network reveals that dysregulation of microRNA-19a / Cyclin_D1 axis confers an oncogenic potential and a worse prognosis in human hepatocellular_carcinoma .
16230390	0	Cyclin_D1	0,9	nuclear_factor-kappaB	48,69	Cyclin D1	nuclear factor-kappaB	595	4790	Gene	Gene	induction|amod|START_ENTITY induction|parataxis|responsible responsible|nsubj|pathway pathway|amod|END_ENTITY	Cyclin_D1 induction through IkappaB_kinase_beta / nuclear_factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes .
16864783	0	Cyclin_D1	0,9	nuclear_respiratory_factor_1	24,52	Cyclin D1	nuclear respiratory factor 1	595	4899	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	Cyclin_D1 repression of nuclear_respiratory_factor_1 integrates nuclear DNA synthesis and mitochondrial function .
10376532	0	Cyclin_D1	0,9	p16	42,45	Cyclin D1	p16	595	1029	Gene	Gene	amplification|amod|START_ENTITY independent|nsubj|amplification independent|nmod|inactivation inactivation|amod|END_ENTITY	Cyclin_D1 amplification is independent of p16 inactivation in head_and_neck_squamous_cell_carcinoma .
20948919	0	Cyclin_D1	28,37	p16	23,26	Cyclin D1	p16	595	1029	Gene	Gene	proteins|amod|START_ENTITY role|appos|proteins role|appos|END_ENTITY	Prognostic role of Rb , p16 , Cyclin_D1 proteins in soft tissue sarcomas .
23786849	0	Cyclin_D1	0,9	p21	26,29	Cyclin D1	p21	595	644914	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|invasion invasion|amod|END_ENTITY	Cyclin_D1 cooperates with p21 to regulate TGFb-mediated breast_cancer_cell_migration_and_tumor local invasion .
27039754	0	Cyclin_D1	5,14	p21	16,19	Cyclin D1	p21	595	1026	Gene	Gene	p53|appos|START_ENTITY p53|appos|END_ENTITY	p53 , Cyclin_D1 , p21 -LRB- WAF1 -RRB- and Ki-67 -LRB- MIB1 -RRB- Expression at Invasive Tumour Fronts of Oral_Squamous_Cell_Carcinomas and Development of Local Recurrence .
11590147	0	Cyclin_D1	0,9	p27	91,94	Cyclin D1	p27	595	10671	Gene	Gene	overexpression|amod|START_ENTITY induces|nsubj|overexpression induces|nmod|association association|amod|END_ENTITY	Cyclin_D1 overexpression induces progestin resistance in T-47D breast_cancer cells despite p27 -LRB- Kip1 -RRB- association with cyclin E-Cdk2 .
17047061	0	Cyclin_D1	0,9	p27	51,54	Cyclin D1	p27	595	3429	Gene	Gene	induction|amod|START_ENTITY requires|nsubj|induction requires|dobj|END_ENTITY	Cyclin_D1 induction of cellular migration requires p27 -LRB- KIP1 -RRB- .
20837141	0	Cyclin_D1	0,9	p27	20,23	Cyclin D1	p27	595	10671	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Cyclin_D1 regulates p27 -LRB- Kip1 -RRB- stability in B cells .
10376986	0	Cyclin_D1	0,9	p53	82,85	Cyclin D1	p53	595	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|association association|nmod|expression expression|compound|END_ENTITY	Cyclin_D1 expression in non-small-cell_lung_cancers : its association with altered p53 expression , cell proliferation and clinical outcome .
10766394	0	Cyclin_D1	0,9	p53	106,109	Cyclin D1	p53	595	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|relevance relevance|nmod|expression expression|compound|END_ENTITY	Cyclin_D1 expression in oral_squamous_cell_carcinomas : clinicopathological relevance and correlation with p53 expression .
11161387	0	Cyclin_D1	0,9	p53	85,88	Cyclin D1	p53	595	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Cyclin_D1 expression in transitional_cell_carcinoma of the bladder : correlation with p53 , waf1 , pRb and Ki67 .
24213463	0	Cyclin_D1	40,49	p53	35,38	Cyclin D1	p53	595	7157	Gene	Gene	Ki67|dep|START_ENTITY Ki67|compound|END_ENTITY	Automated Quantitative Analysis of p53 , Cyclin_D1 , Ki67 and pERK Expression in Breast_Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics .
8552389	0	Cyclin_D1	0,9	p53	44,47	Cyclin D1	p53	12443(Tax:10090)	22060(Tax:10090)	Gene	Gene	involved|nsubj|START_ENTITY involved|nmod|suppression suppression|compound|END_ENTITY	Cyclin_D1 and p21/waf1 are both involved in p53 growth suppression .
9374720	0	Cyclin_D1	0,9	pRb	37,40	Cyclin D1	pRb	595	5925	Gene	Gene	RNA|compound|START_ENTITY destabilizes|nsubj|RNA destabilizes|dobj|growth growth|compound|END_ENTITY	Cyclin_D1 antisense RNA destabilizes pRb and retards lung_cancer cell growth .
16510571	0	Cyclin_D1	0,9	signal_transducer_and_activator_of_transcription_3	89,139	Cyclin D1	signal transducer and activator of transcription 3	595	6774	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cyclin_D1 is transcriptionally regulated by and required for transformation by activated signal_transducer_and_activator_of_transcription_3 .
9178893	0	Cyclin_D2	0,9	Cdk2	20,24	Cyclin D2	Cdk2	894	1017	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cyclin_D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells .
9178893	0	Cyclin_D2	0,9	Cdk4	42,46	Cyclin D2	Cdk4	894	1019	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Cyclin_D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells .
12011445	0	Cyclin_D3	0,9	Caspase_2	20,29	Cyclin D3	Caspase 2	896	835	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cyclin_D3 activates Caspase_2 , connecting cell proliferation with cell death .
15358120	0	Cyclin_D3	0,9	activating_transcription_factor_5	31,64	Cyclin D3	activating transcription factor 5	896	22809	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cyclin_D3 interacts with human activating_transcription_factor_5 and potentiates its transcription activity .
20066559	0	Cyclin_D3	0,9	p58	16,19	Cyclin D3	p58	896	984	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubj|CDK11 CDK11|appos|END_ENTITY	Cyclin_D3 / CDK11 -LRB- p58 -RRB- complex involved in Schwann cells proliferation repression caused by lipopolysaccharide .
16260612	0	Cyclin_D3	0,9	peroxisome_proliferator-activated_receptor_gamma	54,102	Cyclin D3	peroxisome proliferator-activated receptor gamma	12445(Tax:10090)	19016(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Cyclin_D3 promotes adipogenesis through activation of peroxisome_proliferator-activated_receptor_gamma .
11257126	0	Cyclin_E	0,8	Cdc6	14,18	Cyclin E	Cdc6	397841(Tax:8355)	403388(Tax:8355)	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Cyclin_E uses Cdc6 as a chromatin-associated receptor required for DNA replication .
22120721	0	Cyclin_E1	0,9	BMI1	32,36	Cyclin E1	BMI1	898	648	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cyclin_E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression .
25830480	0	Cyclin_E1	40,49	HuR	22,25	Cyclin E1	HuR	898	1994	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	MicroRNA-16 Modulates HuR Regulation of Cyclin_E1 in Breast_Cancer Cells .
25557911	0	Cyclin_F	0,8	B-Myb	20,25	Cyclin F	B-Myb	899	4605	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|amod|END_ENTITY	Cyclin_F suppresses B-Myb activity to promote cell cycle checkpoint control .
10716937	0	Cyclin_F	0,8	cyclin_B1	47,56	Cyclin F	cyclin B1	899	891	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Cyclin_F regulates the nuclear localization of cyclin_B1 through a cyclin-cyclin interaction .
18667003	0	Cyclin_G	34,42	Abd-B	14,19	Cyclin G	Abd-B	43724(Tax:7227)	47763(Tax:7227)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Abd-B expression by Cyclin_G and Corto in the abdominal epithelium of Drosophila .
11983168	0	Cyclin_G	0,8	PP2A	18,22	Cyclin G	PP2A	900	5524	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Cyclin_G recruits PP2A to dephosphorylate Mdm2 .
7957050	0	Cyclin_G	0,8	p53	44,47	Cyclin G	p53	12450(Tax:10090)	22060(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|protein protein|compound|END_ENTITY	Cyclin_G is a transcriptional target of the p53 tumor suppressor protein .
22262175	0	Cyclin_G-associated_kinase	0,26	phosphatase_2A	45,59	Cyclin G-associated kinase	phosphatase 2A	2580	5524	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cyclin_G-associated_kinase regulates protein phosphatase_2A by phosphorylation of its B ' y subunit .
17616664	0	Cyclin_G1	0,9	miR-122a	25,33	Cyclin G1	miR-122a	900	406906	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cyclin_G1 is a target of miR-122a , a microRNA frequently down-regulated in human hepatocellular_carcinoma .
25822739	0	Cyclin_G_Associated_Kinase	24,50	GAK	52,55	Cyclin G Associated Kinase	GAK	2580	2580	Gene	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|appos|END_ENTITY	Selective Inhibitors of Cyclin_G_Associated_Kinase -LRB- GAK -RRB- as Anti-Hepatitis_C Agents .
17937931	0	Cyclin_G_associated_kinase	0,26	beta2	66,71	Cyclin G associated kinase	beta2	2580	10242	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cyclin_G_associated_kinase interacts with interleukin 12 receptor beta2 and suppresses interleukin 12 induced IFN-gamma production .
19591820	0	Cyclin_J	11,19	Cdk1	44,48	Cyclin J	Cdk1	38428(Tax:7227)	34411(Tax:7227)	Gene	Gene	partner|nsubj|START_ENTITY partner|amod|END_ENTITY	Drosophila Cyclin_J is a mitotically stable Cdk1 partner without essential functions .
22512864	0	Cyclin_K	0,8	Cdk12	19,24	Cyclin K	Cdk12	8812	51755	Gene	Gene	goes|nsubj|START_ENTITY goes|nmod|END_ENTITY	Cyclin_K goes with Cdk12 and Cdk13 .
21740905	0	Cyclin_T2	0,9	miR-15a	19,26	Cyclin T2	miR-15a	72949(Tax:10090)	387174(Tax:10090)	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	Cyclin_T2 : a novel miR-15a target gene involved in early spermatogenesis .
19524571	0	Cyclin_Y	0,8	PFTK1	61,66	Cyclin Y	PFTK1	219771	5218	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cyclin_Y , a novel membrane-associated cyclin , interacts with PFTK1 .
9705828	0	Cyclo-oxygenase-2	0,17	ICAM-1	38,44	Cyclo-oxygenase-2	ICAM-1	5743	3383	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Cyclo-oxygenase-2 regulates inducible ICAM-1 and VCAM-1 expression in human vascular smooth muscle cells .
10821793	0	Cyclo-oxygenase-2	0,17	vascular_endothelial_growth_factor	100,134	Cyclo-oxygenase-2	vascular endothelial growth factor	29527(Tax:10116)	83785(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|induction induction|nmod|END_ENTITY	Cyclo-oxygenase-2 enhances basic_fibroblast_growth_factor-induced angiogenesis through induction of vascular_endothelial_growth_factor in rat sponge implants .
11378164	0	Cyclooxygenase-1	0,16	cyclooxygenase-2	21,37	Cyclooxygenase-1	cyclooxygenase-2	24693(Tax:10116)	29527(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes .
15893191	0	Cyclooxygenase-1	0,16	cyclooxygenase-2	103,119	Cyclooxygenase-1	cyclooxygenase-2	19224(Tax:10090)	19225(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	Cyclooxygenase-1 mediates the final stage of morphine-induced delayed cardioprotection in concert with cyclooxygenase-2 .
23777936	0	Cyclooxygenase-2	13,29	AIF-1	94,99	Cyclooxygenase-2	AIF-1	5743	199	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Influence of Cyclooxygenase-2 -LRB- COX-2 -RRB- gene promoter-1195 and allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- polymorphisms on allograft outcome in Hispanic_kidney_transplant_recipients .
17325551	0	Cyclooxygenase-2	0,16	BMPR1A	98,104	Cyclooxygenase-2	BMPR1A	5743	657	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cyclooxygenase-2 expression in polyps from a patient with juvenile_polyposis_syndrome with mutant BMPR1A .
22718198	0	Cyclooxygenase-2	0,16	CCR7	30,34	Cyclooxygenase-2	CCR7	5743	1236	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast_cancer cells .
12089724	0	Cyclooxygenase-2	0,16	COX-2	18,23	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression by immunohistochemistry in glioblastoma multiforme .
12504032	0	Cyclooxygenase-2	0,16	COX-2	18,23	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression in locally advanced cervical_cancer patients undergoing chemoradiation plus surgery .
14633140	0	Cyclooxygenase-2	0,16	COX-2	18,23	Cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition limits abnormal COX-2 expression and progressive injury_in_the_remnant_kidney .
16557596	0	Cyclooxygenase-2	0,16	COX-2	18,23	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression is an independent predictor of prostate_cancer recurrence .
17354612	0	Cyclooxygenase-2	0,16	COX-2	18,23	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human endometrial_carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy .
19031117	0	Cyclooxygenase-2	0,16	COX-2	57,62	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- in carcinogenesis and selective COX-2 inhibitors for chemoprevention in gastrointestinal_cancers .
23777936	0	Cyclooxygenase-2	13,29	COX-2	31,36	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Influence of Cyclooxygenase-2 -LRB- COX-2 -RRB- gene promoter-1195 and allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- polymorphisms on allograft outcome in Hispanic_kidney_transplant_recipients .
23973990	0	Cyclooxygenase-2	0,16	COX-2	18,23	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition constrains indoleamine_2 ,3 - dioxygenase_1 -LRB- IDO1 -RRB- activity in acute_myeloid_leukaemia cells .
25683901	0	Cyclooxygenase-2	34,50	COX-2	52,57	Cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Immunohistochemical Expression of Cyclooxygenase-2 -LRB- COX-2 -RRB- in Feline Endometrial_Adenocarcinoma and in Normal and Hyperplastic Endometria .
17530268	0	Cyclooxygenase-2	13,29	E-cadherin	53,63	Cyclooxygenase-2	E-cadherin	5743	999	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	DNA content , Cyclooxygenase-2 expression and loss of E-cadherin expression do not predict risk of malignant_transformation_in_oral_lichen_planus .
19940363	0	Cyclooxygenase-2	0,16	E-cadherin	40,50	Cyclooxygenase-2	E-cadherin	5743	999	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric_cancer cell lines .
20145033	0	Cyclooxygenase-2	0,16	EGFR-STAT3	66,76	Cyclooxygenase-2	EGFR-STAT3	5743	1956;6774	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes .
11901151	0	Cyclooxygenase-2	0,16	HER-2	37,42	Cyclooxygenase-2	HER-2	5743	2064	Gene	Gene	overexpressed|nsubjpass|START_ENTITY overexpressed|nmod|evidence evidence|compound|END_ENTITY	Cyclooxygenase-2 is overexpressed in HER-2 / neu-positive breast_cancer : evidence for involvement of AP-1 and PEA3 .
14744769	0	Cyclooxygenase-2	0,16	HER-2	34,39	Cyclooxygenase-2	HER-2	5743	2064	Gene	Gene	EP1|compound|START_ENTITY EP1|dep|END_ENTITY	Cyclooxygenase-2 induces EP1 - and HER-2 / Neu-dependent vascular_endothelial_growth_factor-C up-regulation : a novel mechanism of lymphangiogenesis in lung_adenocarcinoma .
17166728	0	Cyclooxygenase-2	0,16	IL-1-beta	62,71	Cyclooxygenase-2	IL-1-beta	19225(Tax:10090)	16176(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain_lesions in newborn mice .
25294243	0	Cyclooxygenase-2	0,16	IL-1b	54,59	Cyclooxygenase-2	IL-1b	19225(Tax:10090)	16176(Tax:10090)	Gene	Gene	NLRP3|compound|START_ENTITY NLRP3|dep|Production Production|compound|END_ENTITY	Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1b Production .
16103460	0	Cyclooxygenase-2	0,16	MYH	63,66	Cyclooxygenase-2	MYH	5743	4595	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Cyclooxygenase-2 expression in FAP patients carrying germ line MYH mutations .
25992485	0	Cyclooxygenase-2	12,28	Matrix_Metalloproteinase-1	97,123	Cyclooxygenase-2	Matrix Metalloproteinase-1	5743	4312	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of Cyclooxygenase-2 , Interleukin-1b and Fibroblast_Growth_Factor-2 in the Activation of Matrix_Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage .
26073037	0	Cyclooxygenase-2	41,57	NF-kB	17,22	Cyclooxygenase-2	NF-kB	29527(Tax:10116)	309165(Tax:10116)	Gene	Gene	Translocation|nmod|START_ENTITY Translocation|nmod|END_ENTITY	Translocation of NF-kB and Expression of Cyclooxygenase-2 Are Enhanced by Ketamine-Induced Ulcerative_Cystitis in Rat Bladder .
12466023	0	Cyclooxygenase-2	0,16	NF-kappaB	46,55	Cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Cyclooxygenase-2 is a neuronal target gene of NF-kappaB .
18302504	0	Cyclooxygenase-2	0,16	OGR1	93,97	Cyclooxygenase-2	OGR1	5743	8111	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cyclooxygenase-2 expression and prostaglandin_E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line .
23810915	0	Cyclooxygenase-2	7,23	PTGS2	0,5	Cyclooxygenase-2	PTGS2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	PTGS2 -LRB- Cyclooxygenase-2 -RRB- expression and survival among colorectal_cancer patients : a systematic review .
25422234	0	Cyclooxygenase-2	104,120	Phospholipase_A2_Group_IIA	18,44	Cyclooxygenase-2	Phospholipase A2 Group IIA	5743	5320	Gene	Gene	Expression|compound|START_ENTITY Overexpression|nmod|Expression Overexpression|nmod|END_ENTITY	Overexpression of Phospholipase_A2_Group_IIA in Esophageal_Squamous_Cell_Carcinoma and Association with Cyclooxygenase-2 Expression .
20631885	0	Cyclooxygenase-2	24,40	Redox_Factor-1	0,14	Cyclooxygenase-2	Redox Factor-1	5743	328	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Redox_Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells .
22718198	0	Cyclooxygenase-2	0,16	Sp1	97,100	Cyclooxygenase-2	Sp1	5743	6667	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast_cancer cells .
11326316	0	Cyclooxygenase-2	0,16	VEGF	41,45	Cyclooxygenase-2	VEGF	5743	7422	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|expression expression|amod|END_ENTITY	Cyclooxygenase-2 pathway correlates with VEGF expression in head_and_neck_cancer .
23877023	0	Cyclooxygenase-2	0,16	arginine_vasopressin	73,93	Cyclooxygenase-2	arginine vasopressin	19225(Tax:10090)	11998(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine_vasopressin .
18001219	0	Cyclooxygenase-2	0,16	aromatic_hydrocarbon_receptor	44,73	Cyclooxygenase-2	aromatic hydrocarbon receptor	5743	196	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Cyclooxygenase-2 promoter activation by the aromatic_hydrocarbon_receptor in breast_cancer mcf-7 cells : repressive effects of conjugated linoleic_acid .
14517215	0	Cyclooxygenase-2	0,16	bradykinin	30,40	Cyclooxygenase-2	bradykinin	5743	3827	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic_AMP response element through a novel autocrine loop involving endogenous prostaglandin_E2 , E-prostanoid_2 -LRB- EP2 -RRB- , and EP4 receptors .
16143655	0	Cyclooxygenase-2	0,16	bradykinin	30,40	Cyclooxygenase-2	bradykinin	5743	3827	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|END_ENTITY	Cyclooxygenase-2 induction by bradykinin in aortic vascular smooth muscle cells .
10766162	0	Cyclooxygenase-2	0,16	c-MYB	98,103	Cyclooxygenase-2	c-MYB	5743	4602	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Cyclooxygenase-2 , a colorectal_cancer nonsteroidal anti-inflammatory drug target , is regulated by c-MYB .
26744410	0	Cyclooxygenase-2	25,41	c8orf4	60,66	Cyclooxygenase-2	c8orf4	5743	56892	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Epigenetic Regulation of Cyclooxygenase-2 by methylation of c8orf4 in Pulmonary Fibrosis .
12391278	0	Cyclooxygenase-2	0,16	endothelin-1	48,60	Cyclooxygenase-2	endothelin-1	5743	1906	Gene	Gene	acts|amod|START_ENTITY acts|nmod|brake brake|nmod|release release|amod|END_ENTITY	Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells : implications for pulmonary_hypertension .
15777970	0	Cyclooxygenase-2	0,16	epidermal_growth_factor_receptor	51,83	Cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	levels|amod|START_ENTITY independent|nsubj|levels independent|nmod|expression expression|compound|END_ENTITY	Cyclooxygenase-2 protein levels are independent of epidermal_growth_factor_receptor expression or activation in operable non-small_cell_lung_cancer .
15844661	0	Cyclooxygenase-2	0,16	epidermal_growth_factor_receptor	108,140	Cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	induction|amod|START_ENTITY induction|nmod|squamous_cell_carcinoma squamous_cell_carcinoma|nmod|consequence consequence|nmod|END_ENTITY	Cyclooxygenase-2 induction and prostaglandin_E2 accumulation in squamous_cell_carcinoma as a consequence of epidermal_growth_factor_receptor activation by imatinib_mesylate .
17572069	0	Cyclooxygenase-2	0,16	epidermal_growth_factor_receptor	36,68	Cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	Cyclooxygenase-2 transactivates the epidermal_growth_factor_receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme .
18645679	0	Cyclooxygenase-2	0,16	epidermal_growth_factor_receptor	46,78	Cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	expression|amod|START_ENTITY dependent|nsubj|expression dependent|nmod|expression expression|compound|END_ENTITY	Cyclooxygenase-2 expression is dependent upon epidermal_growth_factor_receptor expression or activation in androgen_independent_prostate_cancer .
19585617	0	Cyclooxygenase-2	0,16	epidermal_growth_factor_receptor	76,108	Cyclooxygenase-2	epidermal growth factor receptor	19225(Tax:10090)	13649(Tax:10090)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|nmod|up-regulation up-regulation|nmod|END_ENTITY	Cyclooxygenase-2 prevents fas-induced liver_injury through up-regulation of epidermal_growth_factor_receptor .
19671676	0	Cyclooxygenase-2	0,16	epidermal_growth_factor_receptor	60,92	Cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- negatively regulates expression of epidermal_growth_factor_receptor and causes resistance to gefitinib in COX-2-overexpressing cancer cells .
10712390	0	Cyclooxygenase-2	0,16	granulocyte-macrophage_colony-stimulating_factor	27,75	Cyclooxygenase-2	granulocyte-macrophage colony-stimulating factor	5743	1437	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Cyclooxygenase-2 regulates granulocyte-macrophage_colony-stimulating_factor , but not interleukin-8 , production by human vascular cells : role of cAMP .
18300015	0	Cyclooxygenase-2	28,44	growth_hormone	10,24	Cyclooxygenase-2	growth hormone	29527(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of growth_hormone on Cyclooxygenase-2 expression in the hippocampus of rats chronically exposed to ozone .
20103725	0	Cyclooxygenase-2	0,16	her-2	96,101	Cyclooxygenase-2	her-2	19225(Tax:10090)	13866(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|model model|amod|END_ENTITY	Cyclooxygenase-2 inhibition for the prophylaxis and treatment of preinvasive breast_cancer in a her-2 / neu mouse model .
11518681	0	Cyclooxygenase-2	0,16	inducible_nitric_oxide_synthase	31,62	Cyclooxygenase-2	inducible nitric oxide synthase	29527(Tax:10116)	24599(Tax:10116)	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Cyclooxygenase-2 downregulates inducible_nitric_oxide_synthase in rat intestinal epithelial cells .
12839952	0	Cyclooxygenase-2	0,16	interleukin-1_beta	36,54	Cyclooxygenase-2	interleukin-1 beta	5743	3553	Gene	Gene	up-regulated|nsubj|START_ENTITY up-regulated|advcl|END_ENTITY	Cyclooxygenase-2 is up-regulated by interleukin-1_beta in human colorectal_cancer cells via multiple signaling pathways .
11489266	0	Cyclooxygenase-2	0,16	interleukin-1beta	58,75	Cyclooxygenase-2	interleukin-1beta	19225(Tax:10090)	16176(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta .
12050157	0	Cyclooxygenase-2	0,16	interleukin-1beta	61,78	Cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	expression|compound|START_ENTITY expression|acl|induced induced|nmod|peptide peptide|amod|END_ENTITY	Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells .
16752205	0	Cyclooxygenase-2	0,16	membrane-type-1_matrix_metalloproteinase	44,84	Cyclooxygenase-2	membrane-type-1 matrix metalloproteinase	5743	4323	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|amod|END_ENTITY	Cyclooxygenase-2 expression correlates with membrane-type-1_matrix_metalloproteinase expression in colorectal_cancer tissue .
26556718	0	Cyclooxygenase-2	0,16	miR-101	66,73	Cyclooxygenase-2	miR-101	5743	387143(Tax:10090)	Gene	Gene	Regulated|nsubjpass|START_ENTITY Regulated|nmod|END_ENTITY	Cyclooxygenase-2 , a Potential Therapeutic Target , Is Regulated by miR-101 in Esophageal_Squamous_Cell_Carcinoma .
12749290	0	Cyclooxygenase-2	0,16	mucin	26,31	Cyclooxygenase-2	mucin	5743	100508689	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|secretion secretion|compound|END_ENTITY	Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder .
11756433	0	Cyclooxygenase-2	0,16	p53	156,159	Cyclooxygenase-2	p53	19225(Tax:10090)	22060(Tax:10090)	Gene	Gene	overexpression|amod|START_ENTITY inhibits|nsubj|overexpression inhibits|dobj|growth growth|acl:relcl|inhibitors inhibitors|nsubj|proliferation proliferation|nmod|induction induction|nmod|END_ENTITY	Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1 / cip-1 and p27kip-1 .
15550400	0	Cyclooxygenase-2	0,16	p53	109,112	Cyclooxygenase-2	p53	5743	7157	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|apoptosis apoptosis|nmod|activity activity|compound|END_ENTITY	Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate_cancer cell line .
15608668	0	Cyclooxygenase-2	0,16	p53	32,35	Cyclooxygenase-2	p53	5743	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis .
16865247	0	Cyclooxygenase-2	0,16	p53	102,105	Cyclooxygenase-2	p53	5743	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|association association|nmod|outcome outcome|compound|END_ENTITY	Cyclooxygenase-2 expression in squamous_cell_carcinoma_of_the_oral_cavity and pharynx : association to p53 and clinical outcome .
19465063	0	Cyclooxygenase-2	0,16	p53	42,45	Cyclooxygenase-2	p53	5743	7157	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53 .
19465063	0	Cyclooxygenase-2	0,16	p53	82,85	Cyclooxygenase-2	p53	5743	7157	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|nmod|interaction interaction|nmod|END_ENTITY	Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53 .
10406830	0	Cyclooxygenase-2	0,16	renin	38,43	Cyclooxygenase-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY decreases|nsubj|inhibition decreases|dobj|content content|compound|END_ENTITY	Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular_hypertension .
12560203	0	Cyclooxygenase-2	0,16	renin	41,46	Cyclooxygenase-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats .
11957147	0	Cyclooxygenase-2	0,16	vascular_endothelial_growth_factor	104,138	Cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Cyclooxygenase-2 expression in endometrial_cancer : correlation with microvessel count and expression of vascular_endothelial_growth_factor and thymidine_phosphorylase .
12811205	0	Cyclooxygenase-2	0,16	vascular_endothelial_growth_factor	48,82	Cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|expression expression|compound|END_ENTITY	Cyclooxygenase-2 overexpression correlates with vascular_endothelial_growth_factor expression and tumor angiogenesis in gastric_cancer .
14532971	0	Cyclooxygenase-2	0,16	vascular_endothelial_growth_factor	29,63	Cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Cyclooxygenase-2 upregulates vascular_endothelial_growth_factor expression and angiogenesis in human gastric_carcinoma .
15375582	0	Cyclooxygenase-2	0,16	vascular_endothelial_growth_factor	124,158	Cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	START_ENTITY|dep|correlations correlations|nmod|density density|appos|expression expression|nmod|END_ENTITY	Cyclooxygenase-2 in human malignant_fibrous_histiocytoma : correlations with intratumoral microvessel density , expression of vascular_endothelial_growth_factor and thymidine_phosphorylase .
15883203	0	Cyclooxygenase-2	0,16	vascular_endothelial_growth_factor	37,71	Cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|expression expression|compound|END_ENTITY	Cyclooxygenase-2 inhibitors decrease vascular_endothelial_growth_factor expression in colon_cancer cells by enhanced degradation of Sp1 and Sp4 proteins .
15968728	0	Cyclooxygenase-2	0,16	vascular_endothelial_growth_factor	53,87	Cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Cyclooxygenase-2 promotes angiogenesis by increasing vascular_endothelial_growth_factor and predicts prognosis in gallbladder_carcinoma .
21219643	0	Cyclooxygenase-2	0,16	vascular_endothelial_growth_factor	30,64	Cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Cyclooxygenase-2 up-regulates vascular_endothelial_growth_factor via a protein_kinase_C pathway in non-small_cell_lung_cancer .
11509229	0	Cyclooxygenase_1	0,16	interleukin-1	62,75	Cyclooxygenase 1	interleukin-1	19224(Tax:10090)	111343(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Cyclooxygenase_1 is not essential for hypophagic responses to interleukin-1 and endotoxin in mice .
16277613	0	Cyclooxygenase_2	0,16	COX-2	18,23	Cyclooxygenase 2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Cyclooxygenase_2 -LRB- COX-2 -RRB- inhibition increases the inflammatory response in the brain during systemic immune stimuli .
24669166	0	Cyclooxygenase_2	8,24	COX-2	26,31	Cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Cyclooxygenase_2 -LRB- COX-2 -RRB- in Prognosis of Breast_Cancer .
15228443	0	Cyclooxygenase_2	0,16	COX2	18,22	Cyclooxygenase 2	COX2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclooxygenase_2 -LRB- COX2 -RRB- expression is associated with poor outcome in ER-negative , but not ER-positive , breast_cancer .
26065686	0	Cyclooxygenase_2	85,101	Protein_Tyrosine_Phosphatase_1B	24,55	Cyclooxygenase 2	Protein Tyrosine Phosphatase 1B	19225(Tax:10090)	19246(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|dep|Expression	Correction : Deletion of Protein_Tyrosine_Phosphatase_1B -LRB- PTP1B -RRB- Enhances Endothelial Cyclooxygenase_2 Expression and Protects Mice from Type 1 Diabetes-Induced_Endothelial_Dysfunction .
25550208	0	Cyclophilin_A	14,27	EMMPRIN	52,59	Cyclophilin A	EMMPRIN	268373(Tax:10090)	12215(Tax:10090)	Gene	Gene	Activates|nsubj|START_ENTITY Activates|dobj|END_ENTITY	Extracellular Cyclophilin_A Activates Platelets Via EMMPRIN -LRB- CD147 -RRB- and PI3K/Akt Signaling , Which Promotes Platelet Adhesion and Thrombus Formation In Vitro and In Vivo .
7541038	0	Cyclophilin_A	0,13	YY1	39,42	Cyclophilin A	YY1	5478	7528	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Cyclophilin_A and FKBP12 interact with YY1 and alter its transcriptional activity .
19228691	0	Cyclophilin_D	0,13	Bcl2	29,33	Cyclophilin D	Bcl2	5481	596	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cyclophilin_D interacts with Bcl2 and exerts an anti-apoptotic effect .
25301066	0	Cyclophilin_D	34,47	miR-30b	15,22	Cyclophilin D	miR-30b	105675(Tax:10090)	387226(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	E2F1-regulated miR-30b suppresses Cyclophilin_D and protects heart from ischemia/reperfusion injury and necrotic cell death .
17071620	0	Cyclophilin_a	0,13	Peg3	23,27	Cyclophilin a	Peg3	268373(Tax:10090)	18616(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Cyclophilin_a protects Peg3 from hypermethylation and inactive histone modification .
25484988	0	Cyclosporin_A	52,65	AP-1	28,32	Cyclosporin A	AP-1	71991(Tax:10090)	16476(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Expression|nmod|Signaling Expression|compound|END_ENTITY	Enhancement of Flow-Induced AP-1 Gene Expression by Cyclosporin_A Requires NFAT-Independent Signaling in Bone Cells .
9879517	0	Cyclosporin_A	0,13	AP-1	55,59	Cyclosporin A	AP-1	1161	3725	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Cyclosporin_A inhibits collagenase gene expression via AP-1 and JNK suppression in human gingival fibroblasts .
1672137	0	Cyclosporin_A	0,13	ICAM-1	25,31	Cyclosporin A	ICAM-1	1161	3383	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Cyclosporin_A suppresses ICAM-1 expression by papillary endothelium in healing psoriatic plaques .
8484104	0	Cyclosporin_A	0,13	IL-6	66,70	Cyclosporin A	IL-6	71991(Tax:10090)	16193(Tax:10090)	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Cyclosporin_A does not inhibit IL-1 alpha-induced epithelial cell IL-6 secretion .
19735720	0	Cyclosporin_A	0,13	P-glycoprotein	86,100	Cyclosporin A	P-glycoprotein	1161	5243	Gene	Gene	sensitises|nsubj|START_ENTITY sensitises|advcl|imatinib_mesylate imatinib_mesylate|nmod|expression expression|amod|END_ENTITY	Cyclosporin_A sensitises Bcr-Abl positive cells to imatinib_mesylate independently of P-glycoprotein expression .
15890490	0	Cyclosporin_A	23,36	SPARC	50,55	Cyclosporin A	SPARC	1161	6678	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Differential effect of Cyclosporin_A and FK506 on SPARC mRNA expression by human gingival fibroblasts .
6332315	0	Cyclosporin_A	0,13	T-cell_growth_factor	23,43	Cyclosporin A	T-cell growth factor	1442	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Cyclosporin_A inhibits T-cell_growth_factor gene expression at the level of mRNA transcription .
15175101	0	Cyclosporin_A	0,13	VEGF	56,60	Cyclosporin A	VEGF	1161	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Cyclosporin_A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling .
10225546	0	Cyclosporin_A	0,13	interleukin-1beta	24,41	Cyclosporin A	interleukin-1beta	1161	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Cyclosporin_A regulates interleukin-1beta and interleukin-6 expression in gingiva : implications for gingival_overgrowth .
8258320	0	Cyclosporin_A	0,13	interleukin-2	47,60	Cyclosporin A	interleukin-2	1442	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|compound|END_ENTITY	Cyclosporin_A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein_kinase_C_isoenzyme , _ protein_kinase_C-beta .
10704080	0	Cyclosporin_A	0,13	interleukin-6	41,54	Cyclosporin A	interleukin-6	1161	3569	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|synthesis synthesis|amod|END_ENTITY	Cyclosporin_A decreases human macrophage interleukin-6 synthesis at post-transcriptional level .
12958044	0	Cyclosporin_A	0,13	interleukin-8	23,36	Cyclosporin A	interleukin-8	1161	3576	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Cyclosporin_A enhances interleukin-8 expression by inducing activator_protein-1 in human aortic smooth muscle cells .
11368976	0	Cyclosporin_A	0,13	p-glycoprotein	54,68	Cyclosporin A	p-glycoprotein	71991(Tax:10090)	67078(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	Cyclosporin_A inhibits the extrusion pump function of p-glycoprotein in the inner ear of mice treated with vinblastine and doxorubicin .
11128920	0	Cyclosporin_A	0,13	phospholipase_C_beta1	26,47	Cyclosporin A	phospholipase C beta1	1161	23236	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Cyclosporin_A upregulates phospholipase_C_beta1 in fibroblasts from gingival_overgrowth .
16044913	0	Cyclosporin_a	1,14	titin	23,28	Cyclosporin a	titin	1161	7273	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	-LSB- Cyclosporin_a induces titin expression in human trophoblast cells through the MEK/ERK1/2 signal pathway -RSB- .
26884717	0	Cyclosporine_A	0,14	Glucose_Oxidase	26,41	Cyclosporine A	Glucose Oxidase	71991(Tax:10090)	15112(Tax:10090)	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Cyclosporine_A Suppressed Glucose_Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition .
26884717	0	Cyclosporine_A	0,14	P53	50,53	Cyclosporine A	P53	71991(Tax:10090)	22060(Tax:10090)	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Cyclosporine_A Suppressed Glucose_Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition .
7823269	0	Cyclosporine_A	0,14	interleukin-6	27,40	Cyclosporine A	interleukin-6	1161	3569	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Cyclosporine_A upregulates interleukin-6 gene expression in human gingiva : possible mechanism for gingival_overgrowth .
9349985	0	Cyclosporine_A	0,14	interleukin-8	24,37	Cyclosporine A	interleukin-8	1161	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Cyclosporine_A inhibits interleukin-8 production in a human colon epithelial cell line -LRB- HT-29 -RRB- .
18511905	0	Cyk-4	11,16	ECT2	28,32	Cyk-4	ECT2	3851	1894	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis .
7774959	0	Cyl-1	50,55	cyclin_D1	34,43	Cyl-1	cyclin D1	12443(Tax:10090)	12443(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the mouse cyclin_D1 gene -LRB- Cyl-1 -RRB- .
18245814	0	Cylindromatosis	24,39	CYLD	18,22	Cylindromatosis	CYLD	1540	1540	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role of CYLD -LRB- Cylindromatosis -RRB- as a deubiquitinating enzyme in vascular cells .
7669222	0	Cyp11b1	107,114	Cyp11b2	155,162	Cyp11b1	Cyp11b2	500892(Tax:10116)	24294(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene -LRB- Cyp11b1 -RRB- and the rat aldosterone_synthase gene -LRB- Cyp11b2 -RRB- to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains .
7669222	0	Cyp11b2	155,162	Cyp11b1	107,114	Cyp11b2	Cyp11b1	24294(Tax:10116)	500892(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene -LRB- Cyp11b1 -RRB- and the rat aldosterone_synthase gene -LRB- Cyp11b2 -RRB- to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains .
22465514	0	Cyp11b2	100,107	aldosterone_synthase	78,98	Cyp11b2	aldosterone synthase	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A case of primary selective_hypoaldosteronism carrying three mutations in the aldosterone_synthase -LRB- Cyp11b2 -RRB- gene .
21883931	0	Cyp17a1	160,167	cAMP-responsive_element_modulator	98,131	Cyp17a1	cAMP-responsive element modulator	13074(Tax:10090)	12916(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland -- involvement of cAMP-responsive_element_modulator in epigenetic regulation of Cyp17a1 .
25057110	0	Cyp19a1	60,67	TGFb1	38,43	Cyp19a1	TGFb1	25147(Tax:10116)	59086(Tax:10116)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Calcineurin and CRTC2 mediate FSH and TGFb1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells .
9448724	0	Cyp1a1	76,82	AHR	114,117	Cyp1a1	AHR	13076(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|transgenic_mice transgenic_mice|appos|END_ENTITY	The 4S benzo -LRB- a -RRB- pyrene-binding protein is not a transcriptional activator of Cyp1a1 gene in Ah_receptor-deficient -LRB- AHR - / - -RRB- transgenic_mice .
11577022	0	Cyp1a1	41,47	Ahr	104,107	Cyp1a1	Ahr	13076(Tax:10090)	11622(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|factor factor|compound|END_ENTITY	Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells : role of the Ahr bHLH/PAS transcription factor .
8033136	0	Cyp1b1	26,32	cytochrome_P450	9,24	Cyp1b1	cytochrome P450	13078(Tax:10090)	13079(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Enhanced cytochrome_P450 -LRB- Cyp1b1 -RRB- expression , aryl_hydrocarbon hydroxylase activity , cytotoxicity , and transformation of C3H 10T1/2 cells by dimethylbenz -LRB- a -RRB- anthracene in conditioned medium .
15359218	0	Cyp1b1	34,40	cytochrome_P4501b1	14,32	Cyp1b1	cytochrome P4501b1	13078(Tax:10090)	13078(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cytochrome_P4501b1 -LRB- Cyp1b1 -RRB- during early murine development .
8385740	0	Cyp21	65,70	21-hydroxylase	49,63	Cyp21	21-hydroxylase	13079(Tax:10090)	13079(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of promoter elements in the mouse 21-hydroxylase -LRB- Cyp21 -RRB- gene that require a functional cyclic_adenosine_3 ' ,5 ' - monophosphate-dependent protein kinase .
15498883	0	Cyp24a1	151,158	25-hydroxyvitamin_D-24-hydroxylase	115,149	Cyp24a1	25-hydroxyvitamin D-24-hydroxylase	13081(Tax:10090)	13081(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin _ D3 and 25-hydroxyvitamin_D3 in the blood and tissues of the 25-hydroxyvitamin_D-24-hydroxylase -LRB- Cyp24a1 -RRB- null mouse .
25065682	0	Cyp27a1	39,46	Cyp46a1	51,58	Cyp27a1	Cyp46a1	104086(Tax:10090)	13116(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Retinal and nonocular abnormalities in Cyp27a1 -LRB- - / - -RRB- Cyp46a1 -LRB- - / - -RRB- mice with dysfunctional metabolism of cholesterol .
9408084	0	Cyp2a-4	77,84	HNF-4	30,35	Cyp2a-4	HNF-4	13086(Tax:10090)	15378(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY END_ENTITY|nmod|gene	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 -LRB- Cyp2a-4 -RRB- gene in mouse liver .
10490589	0	Cyp2a5	94,100	coumarin_7-hydroxylase	70,92	Cyp2a5	coumarin 7-hydroxylase	13087(Tax:10090)	13087(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Circadian expression of the steroid 15 alpha-hydroxylase -LRB- Cyp2a4 -RRB- and coumarin_7-hydroxylase -LRB- Cyp2a5 -RRB- genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP .
24494203	0	Cyp2b10	94,101	nuclear_factor_erythroid_2-related_factor_2	24,67	Cyp2b10	nuclear factor erythroid 2-related factor 2	13088(Tax:10090)	18024(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of nuclear_factor_erythroid_2-related_factor_2 in the gene expression of Cyp2b10 and Cyp2a5 .
15878984	0	Cyp3a11	43,50	Toll-like_receptor-4	0,20	Cyp3a11	Toll-like receptor-4	13112(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Toll-like_receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation .
21205914	0	Cyp3a11	64,71	steroid_and_xenobiotic_X_receptor	85,118	Cyp3a11	steroid and xenobiotic X receptor	13112(Tax:10090)	18171(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid_and_xenobiotic_X_receptor humanized mice .
11284050	0	Cyp3a25	99,106	cytochrome_P450_3a25	77,97	Cyp3a25	cytochrome P450 3a25	56388(Tax:10090)	56388(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Cloning , sequencing , heterologous expression , and characterization of murine cytochrome_P450_3a25 * -LRB- Cyp3a25 -RRB- , a testosterone 6beta-hydroxylase .
25065682	0	Cyp46a1	51,58	Cyp27a1	39,46	Cyp46a1	Cyp27a1	13116(Tax:10090)	104086(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Retinal and nonocular abnormalities in Cyp27a1 -LRB- - / - -RRB- Cyp46a1 -LRB- - / - -RRB- mice with dysfunctional metabolism of cholesterol .
24066149	0	Cyp4v3	30,36	F11	18,21	Cyp4v3	F11	102294(Tax:10090)	109821(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Regulation of the F11 , Klkb1 , Cyp4v3 gene cluster in livers of metabolically challenged mice .
24066149	0	Cyp4v3	30,36	Klkb1	23,28	Cyp4v3	Klkb1	102294(Tax:10090)	16621(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Regulation of the F11 , Klkb1 , Cyp4v3 gene cluster in livers of metabolically challenged mice .
16713132	0	Cyp6a2	40,46	cytochrome_P450	17,32	Cyp6a2	cytochrome P450	35587(Tax:7227)	45282(Tax:7227)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Induction of two cytochrome_P450 genes , Cyp6a2 and Cyp6a8 , of Drosophila_melanogaster by caffeine in adult flies and in cell culture .
24582860	0	Cyp7a1	68,74	cholesterol_7_alpha-hydroxylase	35,66	Cyp7a1	cholesterol 7 alpha-hydroxylase	1581	1581	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Thyroid hormone induction of human cholesterol_7_alpha-hydroxylase -LRB- Cyp7a1 -RRB- in vitro .
25062088	0	Cyr61	16,21	IGF-1	0,5	Cyr61	IGF-1	3491	3479	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IGF-1 regulates Cyr61 induced breast_cancer cell proliferation and invasion .
22547695	0	Cyr61	0,5	IL-6	14,18	Cyr61	IL-6	3491	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid_arthritis .
24317814	0	Cyr61	67,72	MicroRNA-100	0,12	Cyr61	MicroRNA-100	3491	406892	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MicroRNA-100 inhibits osteosarcoma cell proliferation by targeting Cyr61 .
23196056	0	Cyr61	15,20	Snail	0,5	Cyr61	Snail	3491	6615	Gene	Gene	secretion|amod|START_ENTITY promotes|dobj|secretion promotes|nsubj|END_ENTITY	Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous_cell_carcinoma .
25059387	0	Cyr61	18,23	Sox4	0,4	Cyr61	Sox4	3491	6659	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Sox4 up-regulates Cyr61 expression in colon_cancer cells .
25980494	0	Cyr61	0,5	Src	21,24	Cyr61	Src	3491	6714	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Cyr61 as mediator of Src signaling in triple negative breast cancer cells .
15649872	0	Cyr61	0,5	VEGF	33,37	Cyr61	VEGF	3491	7422	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Cyr61 mediates the expression of VEGF , alphav-integrin , and alpha-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells .
16510585	0	Cyr61	14,19	matrix_metalloproteinase-1	43,69	Cyr61	matrix metalloproteinase-1	3491	4312	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|amod|END_ENTITY	Tumor-derived Cyr61 -LRB- CCN1 -RRB- promotes stromal matrix_metalloproteinase-1 production and protease-activated_receptor_1-dependent migration of breast_cancer cells .
16616811	0	Cyr61	10,15	transforming_growth_factor_beta	52,83	Cyr61	transforming growth factor beta	3491	7040	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	The human Cyr61 gene is a transcriptional target of transforming_growth_factor_beta in cancer cells .
12743568	0	CysLT1	0,6	TGF-beta	32,40	CysLT1	TGF-beta	10800	7040	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4 .
24925646	0	CysLT2	43,49	IL-8	68,72	CysLT2	IL-8	57105	3576	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	ERK/Egr -1 signaling pathway is involved in CysLT2 receptor-mediated IL-8 production in HEK293 cells .
17010308	0	CysLT2	48,54	aquaporin_4	73,84	CysLT2	aquaporin 4	170926(Tax:10116)	25293(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Leukotriene_D4 induces brain_edema and enhances CysLT2 receptor-mediated aquaporin_4 expression .
15990791	0	Cystatin_A	0,10	IL-8	20,24	Cystatin A	IL-8	1475	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Cystatin_A inhibits IL-8 production by keratinocytes stimulated with Der p_1_and_Der_f_1 : biochemical skin barrier against mite cysteine proteases .
24348508	0	Cystatin_C	28,38	Growth_Hormone	10,24	Cystatin C	Growth Hormone	1471	2688	Gene	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of Growth_Hormone on Cystatin_C .
15750984	0	Cystatin_C	1,11	beta2-microglobulin	13,32	Cystatin C	beta2-microglobulin	1471	567	Gene	Gene	START_ENTITY|appos|hemodialysis hemodialysis|amod|END_ENTITY	-LSB- Cystatin_C , beta2-microglobulin and C-reactive_protein in hemodiafiltration and on-line endogenous liquid reinfusion and in low flux polysulphone_bicarbonate conventional hemodialysis -RSB- .
20446879	0	Cystatin_C	47,57	cystatin_C	91,101	Cystatin C	cystatin C	1471	1471	Gene	Gene	assay|compound|START_ENTITY assay|nmod|END_ENTITY	Performance evaluation of the Roche Tina-quant Cystatin_C assay and reference interval for cystatin_C in healthy blood donors .
15037657	0	Cystatin_C	0,10	transforming_growth_factor_beta	23,54	Cystatin C	transforming growth factor beta	1471	7040	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Cystatin_C antagonizes transforming_growth_factor_beta signaling in normal and cancer cells .
15196002	0	Cystatin_SA	0,11	interferon-gamma	54,70	Cystatin SA	interferon-gamma	1470	3458	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Cystatin_SA , a cysteine proteinase inhibitor , induces interferon-gamma expression in CD4-positive T cells .
24357805	0	Cystatin_SN	0,11	cystatin_C	49,59	Cystatin SN	cystatin C	1469	1471	Gene	Gene	neutralizes|nsubj|START_ENTITY neutralizes|dobj|effect effect|nmod|END_ENTITY	Cystatin_SN neutralizes the inhibitory effect of cystatin_C on cathepsin_B activity .
22566095	0	Cysteine-rich_protein_61	0,24	CCN1	26,30	Cysteine-rich protein 61	CCN1	3491	3491	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Cysteine-rich_protein_61 -LRB- CCN1 -RRB- mediates replicative senescence-associated aberrant collagen homeostasis in human skin fibroblasts .
17377140	0	Cysteine-rich_secretory_protein_2	0,33	mitogen-activated_protein_kinase_kinase_kinase_11	43,92	Cysteine-rich secretory protein 2	mitogen-activated protein kinase kinase kinase 11	22024(Tax:10090)	26403(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Cysteine-rich_secretory_protein_2 binds to mitogen-activated_protein_kinase_kinase_kinase_11 in mouse sperm .
15461460	0	Cysteine-rich_secretory_protein_3	0,33	alpha1B-glycoprotein	49,69	Cysteine-rich secretory protein 3	alpha1B-glycoprotein	10321	1	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Cysteine-rich_secretory_protein_3 is a ligand of alpha1B-glycoprotein in human plasma .
26960148	0	Cysteine_Protease	55,72	p41	24,27	Cysteine Protease	p41	1508	5594	Gene	Gene	Activity|compound|START_ENTITY Activity|amod|END_ENTITY	Exogenous Thyropin from p41 Invariant Chain Diminishes Cysteine_Protease Activity and Affects IL-12 Secretion during Maturation of Human Dendritic Cells .
25637537	0	Cysteine_dioxygenase_type_1	0,27	peroxisome_proliferator-activated_receptor_gamma	71,119	Cysteine dioxygenase type 1	peroxisome proliferator-activated receptor gamma	1036	19016(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Cysteine_dioxygenase_type_1 promotes adipogenesis via interaction with peroxisome_proliferator-activated_receptor_gamma .
3438085	0	Cysteine_proteinase	0,19	cathepsin_L	20,31	Cysteine proteinase	cathepsin L	12334(Tax:10090)	13039(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Cysteine_proteinase cathepsin_L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts .
19098309	0	Cysteine_string_protein	0,23	cystic_fibrosis_transmembrane_conductance_regulator	64,115	Cysteine string protein	cystic fibrosis transmembrane conductance regulator	80331	1080	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Cysteine_string_protein promotes proteasomal degradation of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation .
25062999	0	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	0,51	CFTR	61,65	Cystic Fibrosis Transmembrane Conductance Regulator	CFTR	1080	1080	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Cystic_Fibrosis_Transmembrane_Conductance_Regulator Protein -LRB- CFTR -RRB- Expression in the Developing Human Brain : Comparative Immunohistochemical Study between Patients with Normal and Mutated CFTR .
26079370	0	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	48,99	CFTR	101,105	Cystic Fibrosis Transmembrane Conductance Regulator	CFTR	1080	1080	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Sphingosine-1-Phosphate Is a Novel Regulator of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Activity .
26087176	0	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	68,119	CFTR	121,125	Cystic Fibrosis Transmembrane Conductance Regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prevalence of meconium ileus marks the severity of mutations of the Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- gene .
26208274	0	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	16,67	CFTR	69,73	Cystic Fibrosis Transmembrane Conductance Regulator	CFTR	1080	1080	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Distribution of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Mutations in a Cohort of Patients Residing in Palestine .
26208274	0	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	16,67	CFTR	69,73	Cystic Fibrosis Transmembrane Conductance Regulator	CFTR	1080	1080	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Distribution of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Mutations in a Cohort of Patients Residing in Palestine .
26694899	0	Cystic_Fibrosis_Transmembrane_Conductance_Regulator	13,64	CFTR	66,70	Cystic Fibrosis Transmembrane Conductance Regulator	CFTR	1080	1080	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Mutations of Cystic_Fibrosis_Transmembrane_Conductance_Regulator -LRB- CFTR -RRB- Gene Cause a Monocyte-selective Adhesion_Deficiency .
20530751	0	Cystic_fibrosis_transmembrane_conductance_regulator	0,51	CFTR	53,57	Cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- expression in human platelets : impact on mediators and mechanisms of the inflammatory response .
11688801	0	Cyt1Aa	66,72	P19_and_P20	29,40	Cyt1Aa	P19 and P20	5759908(Tax:1430)	5759960(Tax:1430)	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Effect of accessory proteins P19_and_P20 on cytolytic activity of Cyt1Aa from Bacillus_thuringiensis_subsp .
26181065	0	Cytidine_Deaminase	44,62	PARP-1	83,89	Cytidine Deaminase	PARP-1	978	142	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Pyrimidine Pool Disequilibrium Induced by a Cytidine_Deaminase Deficiency Inhibits PARP-1 Activity , Leading to the Under Replication of DNA .
2059079	0	Cytidine_deaminase	0,18	C_reactive_protein	29,47	Cytidine deaminase	C reactive protein	978	1401	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Cytidine_deaminase activity , C_reactive_protein , histidine , and erythrocyte sedimentation rate as measures of disease activity in psoriatic_arthritis .
2036362	0	Cytochrome_P-450scc	0,19	vesicle_aggregation	28,47	Cytochrome P-450scc	cytochrome P-450scc	338048(Tax:9913)	338048(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cytochrome_P-450scc induces vesicle_aggregation through a secondary interaction at the adrenodoxin binding sites -LRB- in competition with protein exchange .
11389879	0	Cytochrome_P450	0,15	CYP1B1	16,22	Cytochrome P450	CYP1B1	4051	1545	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Cytochrome_P450 CYP1B1 protein expression : a novel mechanism of anticancer drug resistance .
16922636	0	Cytochrome_P450	0,15	CYP1B1	71,77	Cytochrome P450	CYP1B1	4051	1545	Gene	Gene	interactions|amod|START_ENTITY interactions|dep|aspects aspects|acl|considering considering|dobj|END_ENTITY	Cytochrome_P450 interactions in human cancers : new aspects considering CYP1B1 .
11717173	0	Cytochrome_P450	0,15	CYP3A	143,148	Cytochrome P450	CYP3A	4051	1576	Gene	Gene	Involvement|compound|START_ENTITY Involvement|dep|activity activity|nmod|isoforms isoforms|compound|END_ENTITY	Cytochrome_P450 Involvement in the biotransformation of cisapride and racemic_norcisapride in vitro : differential activity of individual human CYP3A isoforms .
26182937	0	Cytochrome_P450	102,117	Sp1	8,11	Cytochrome P450	Sp1	4051	6667	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Sp1 , HNF1a , and PXR in the Basal and Rifampicin Induced Transcriptional Regulation of Porcine Cytochrome_P450 3A46 .
17481570	0	Cytochrome_P450	0,15	aryl_hydrocarbon_receptor	76,101	Cytochrome P450	aryl hydrocarbon receptor	13079(Tax:10090)	11622(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY mediated|nsubj|regulation mediated|nmod|END_ENTITY	Cytochrome_P450 gene regulation and physiological functions mediated by the aryl_hydrocarbon_receptor .
2521554	0	Cytochrome_P450	0,15	growth_hormone	58,72	Cytochrome P450	growth hormone	25251(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Cytochrome_P450 in livers of diabetic rats : regulation by growth_hormone and insulin .
11230748	0	Cytochrome_P450	0,15	hepatocyte_nuclear_factor_4	30,57	Cytochrome P450	hepatocyte nuclear factor 4	4051	3172	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Cytochrome_P450 regulation by hepatocyte_nuclear_factor_4 in human hepatocytes : a study using adenovirus-mediated antisense targeting .
11285205	0	Cytochrome_P4501A2	0,18	CYP1A2	20,26	Cytochrome P4501A2	CYP1A2	1544	1544	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Cytochrome_P4501A2 -LRB- CYP1A2 -RRB- activity and lung_cancer risk : a preliminary study among Chinese women in Singapore .
12743671	0	Cytochrome_P4502E1	0,18	CYP2E1	20,26	Cytochrome P4502E1	CYP2E1	1571	1571	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cytochrome_P4502E1 -LRB- CYP2E1 -RRB- expression in peripheral blood lymphocytes : evaluation in hepatitis_C and diabetes .
22294106	0	Cytochrome_P450_1A1	0,19	CYP1A1	21,27	Cytochrome P450 1A1	CYP1A1	1543	1543	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- gene polymorphisms and cervical_cancer risk : a meta-analysis .
22733497	0	Cytochrome_P450_1A1	0,19	CYP1A1	21,27	Cytochrome P450 1A1	CYP1A1	1543	1543	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- gene polymorphisms and ovarian_cancer risk : a meta-analysis .
25048966	0	Cytochrome_P450_1A1	0,19	CYP1A1	21,27	Cytochrome P450 1A1	CYP1A1	1543	1543	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- polymorphism and susceptibility to esophageal_cancer : an updated meta-analysis of 27 studies .
15217501	0	Cytochrome_P450_1A2	0,19	CYP1A2	21,27	Cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity , mammographic density , and oxidative stress : a cross-sectional study .
15217502	0	Cytochrome_P450_1A2	0,19	CYP1A2	21,27	Cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity and risk factors for breast_cancer : a cross-sectional study .
26542054	0	Cytochrome_P450_2D6	19,38	CYP2D6	40,46	Cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of 22 Novel Cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- Variants Found in the Chinese Population on Hemangeol Metabolism In Vitro .
10463580	0	Cytochrome_P450c17alpha	0,23	CYP17	30,35	Cytochrome P450c17alpha	CYP17	1586	1586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cytochrome_P450c17alpha gene -LRB- CYP17 -RRB- polymorphism predicts use of hormone replacement therapy .
9485002	0	Cytochrome_P450c17alpha	0,23	CYP17	30,35	Cytochrome P450c17alpha	CYP17	1586	1586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cytochrome_P450c17alpha gene -LRB- CYP17 -RRB- polymorphism is associated with serum estrogen and progesterone concentrations .
23538781	0	Cytochrome_b	0,12	cytb	19,23	Cytochrome b	cytb	4519	4519	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cytochrome_b gene -LRB- cytb -RRB- sequence diversity in a Microtus oeconomus population from Bialowieza Primeval Forest .
10364241	0	Cytochrome_c	0,12	Apaf-1	50,56	Cytochrome c	Apaf-1	54205	317	Gene	Gene	oligomerization|amod|START_ENTITY oligomerization|nmod|END_ENTITY	Cytochrome_c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation .
10940292	0	Cytochrome_c	0,12	Apaf-1	77,83	Cytochrome c	Apaf-1	54205	317	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inducing inducing|dobj|nucleotide nucleotide|amod|END_ENTITY	Cytochrome_c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 .
9390557	0	Cytochrome_c	0,12	Apaf-1	45,51	Cytochrome c	Apaf-1	54205	317	Gene	Gene	formation|amod|START_ENTITY formation|nmod|END_ENTITY	Cytochrome_c and dATP-dependent formation of Apaf-1 / caspase-9 complex initiates an apoptotic protease cascade .
11264286	0	Cytochrome_c	0,12	Bax	101,104	Cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY occurs|nsubj|release occurs|nmod|+ +|dep|mechanisms mechanisms|acl:relcl|regulated regulated|nmod|END_ENTITY	Cytochrome_c release occurs via Ca2 + - dependent and Ca2 + - independent mechanisms that are regulated by Bax .
9891071	0	Cytochrome_c	5,17	Bcl-2	67,72	Cytochrome c	Bcl-2	54205	596	Gene	Gene	factor|amod|START_ENTITY regulated|dep|factor regulated|nmod|END_ENTITY	Cif -LRB- Cytochrome_c efflux-inducing factor -RRB- activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid .
9694712	0	Cytochrome_c	0,12	bcl-2	127,132	Cytochrome c	bcl-2	54205	596	Gene	Gene	induces|nsubj|START_ENTITY induces|ccomp|apoptosis apoptosis|dobj|suppression suppression|acl|mediated mediated|nmod|END_ENTITY	Cytochrome_c induces caspase-dependent apoptosis in intact hematopoietic cells and overrides apoptosis suppression mediated by bcl-2 , growth factor signaling , MAP-kinase-kinase , and malignant change .
10940292	0	Cytochrome_c	0,12	caspase-9	22,31	Cytochrome c	caspase-9	54205	842	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activation activation|amod|END_ENTITY	Cytochrome_c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 .
11600533	0	Cytochrome_c	0,12	caspase-9	50,59	Cytochrome c	caspase-9	54205	842	Gene	Gene	release|amod|START_ENTITY induced|nsubjpass|release induced|advmod|upstream upstream|nmod|activation activation|acl|END_ENTITY	Cytochrome_c release is upstream to activation of caspase-9 , caspase-8 , and caspase-3 in the enhanced apoptosis of anaplastic_thyroid_cancer cells induced by manumycin and paclitaxel .
9390557	0	Cytochrome_c	0,12	caspase-9	52,61	Cytochrome c	caspase-9	54205	842	Gene	Gene	formation|amod|START_ENTITY formation|dep|initiates initiates|amod|END_ENTITY	Cytochrome_c and dATP-dependent formation of Apaf-1 / caspase-9 complex initiates an apoptotic protease cascade .
11737208	0	Cytochrome_c	0,12	cytochrome_c	13,25	Cytochrome c	cytochrome c	54205	54205	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	Cytochrome_c / cytochrome_c oxidase interaction .
21637466	0	Cytochrome_c_Oxidase_subunit_I	145,175	COI	177,180	Cytochrome c Oxidase subunit I	COI	4512	4512	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Population structure of the Monocelis lineata -LRB- Proseriata , Monocelididae -RRB- species complex assessed by phylogenetic analysis of the mitochondrial Cytochrome_c_Oxidase_subunit_I -LRB- COI -RRB- gene .
23619098	0	Cytochrome_c_oxidase_subunit_III	0,32	COX3	34,38	Cytochrome c oxidase subunit III	COX3	4514	4514	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Cytochrome_c_oxidase_subunit_III -LRB- COX3 -RRB- gene , an informative marker for phylogenetic analysis and differentiation of Babesia species in China .
21233413	0	Cytohesin-1	0,11	Mac-1	80,85	Cytohesin-1	Mac-1	9267	3689	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Cytohesin-1 regulates fMLF-mediated activation and functions of the b2 integrin Mac-1 in human neutrophils .
26378252	0	Cytohesin-2	8,19	ARNO	20,24	Cytohesin-2	ARNO	9266	9266	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	ARF-GEF Cytohesin-2 / ARNO regulates R-Ras and a5-integrin recycling through an EHD1-positive compartment .
20525696	0	Cytohesin-2	0,11	Arf6	154,158	Cytohesin-2	Arf6	19158(Tax:10090)	11845(Tax:10090)	Gene	Gene	ARNO|compound|START_ENTITY regulates|nsubj|ARNO regulates|dobj|migration migration|nmod|activation activation|nmod|END_ENTITY	Cytohesin-2 / ARNO , through its interaction with focal adhesion adaptor protein paxillin , regulates preadipocyte migration via the downstream activation of Arf6 .
25159843	0	Cytohesin-associated_scaffolding_protein	0,40	granzyme_B	67,77	Cytohesin-associated scaffolding protein	granzyme B	9595	3002	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Cytohesin-associated_scaffolding_protein -LRB- CASP -RRB- is a substrate for granzyme_B and ubiquitination .
25450674	0	Cytohesin_2	0,11	ARF6	12,16	Cytohesin 2	ARF6	9266	382	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Cytohesin_2 / ARF6 regulates preadipocyte migration through the activation of ERK1/2 .
25342465	0	Cytokeratin19	0,13	HER2	55,59	Cytokeratin19	HER2	3880	2064	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes .
24532216	0	Cytokeratin_15	31,45	HOXA10	0,6	Cytokeratin 15	HOXA10	3866	3206	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	HOXA10 Regulates Expression of Cytokeratin_15 in Endometrial Epithelial Cytoskeletal Remodeling .
19188603	0	Cytokeratin_20	40,54	CDX1	85,89	Cytokeratin 20	CDX1	54474	1044	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Gastrointestinal differentiation marker Cytokeratin_20 is regulated by homeobox gene CDX1 .
18822384	0	Cytokeratin_8	37,50	SMAR1	17,22	Cytokeratin 8	SMAR1	3856	54971	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Tumor suppressor SMAR1 downregulates Cytokeratin_8 expression by displacing p53 from its cognate site .
11737062	0	Cytokine_receptor	0,17	STAT-1	64,70	Cytokine receptor	STAT-1	8809	6772	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|compound|END_ENTITY	Cytokine_receptor signalling in neonatal macrophages : defective STAT-1 phosphorylation in response to stimulation with IFN-gamma .
12101222	0	Cytosolic_phospholipase_A2	0,26	cPLA2	28,33	Cytosolic phospholipase A2	cPLA2	5321	5321	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Cytosolic_phospholipase_A2 -LRB- cPLA2 -RRB- regulation of human monocyte NADPH oxidase activity .
16806120	0	Cytosolic_prostaglandin_E2_synthase	0,35	cPGES	37,42	Cytosolic prostaglandin E2 synthase	cPGES	10728	10728	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cytosolic_prostaglandin_E2_synthase -LRB- cPGES -RRB- expression is decreased in discrete cortical regions in psychiatric_disease .
18690216	0	Cytosporone_B	0,13	Nur77	56,61	Cytosporone B	Nur77	12991(Tax:10090)	15370(Tax:10090)	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	Cytosporone_B is an agonist for nuclear orphan receptor Nur77 .
16476055	0	Cytotoxic_T-lymphocyte_antigen-4	0,32	GATA-3	42,48	Cytotoxic T-lymphocyte antigen-4	GATA-3	12477(Tax:10090)	14462(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cytotoxic_T-lymphocyte_antigen-4 inhibits GATA-3 but not T-bet mRNA expression during T helper cell differentiation .
8528268	0	D	52,53	CYP2D6	45,51	D	CYP2D6	1238	1565	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of the poor metabolizer-associated CYP2D6 -LRB- D -RRB- gene deletion allele by long-PCR technology .
1294957	0	D-1_to_D-29	46,57	erythropoietin	13,27	D-1 to D-29	erythropoietin	25802;55520	2056	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	-LSB- Kinetics of erythropoietin blood levels from D-1_to_D-29 in kidney transplantation -RSB- .
19797056	0	D-AKAP2	0,7	Rab4	23,27	D-AKAP2	Rab4	11216	5867	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling .
21340027	0	D-Cbl	0,5	Drk	17,20	D-Cbl	Drk	38961(Tax:7227)	36497(Tax:7227)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis .
9178769	0	D-Cbl	0,5	EGF_receptor	91,103	D-Cbl	EGF receptor	38961(Tax:7227)	37455(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	D-Cbl , the Drosophila homologue of the c-Cbl proto-oncogene , interacts with the Drosophila EGF_receptor in vivo , despite lacking C-terminal adaptor binding sites .
19718746	0	D-Pax2	25,31	crystallin	42,52	D-Pax2	crystallin	43825(Tax:7227)	34604(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	The transcription factor D-Pax2 regulates crystallin production during eye development in Drosophila_melanogaster .
2576634	0	D-amino-acid_oxidase	30,50	pgm-1	58,63	D-amino-acid oxidase	pgm-1	13142(Tax:10090)	66681(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Linkage of the Dao-1 gene for D-amino-acid_oxidase to the pgm-1 gene for phosphoglucomutase-1 on the mouse chromosome 5 .
18378121	0	D-amino_acid_oxidase	16,36	DAAO	38,42	D-amino acid oxidase	DAAO	1610	1610	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Increased brain D-amino_acid_oxidase -LRB- DAAO -RRB- activity in schizophrenia .
22454242	0	D-amino_acid_oxidase_activator	0,30	DAOA	37,41	D-amino acid oxidase activator	DAOA	267012	267012	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	D-amino_acid_oxidase_activator gene -LRB- DAOA -RRB- variation affects cerebrospinal fluid homovanillic_acid concentrations in healthy Caucasians .
10073940	0	D-axin	45,51	axin	77,81	D-axin	axin	43565(Tax:7227)	43565(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Negative regulation of Wingless signaling by D-axin , a Drosophila homolog of axin .
21071513	0	D-dopachrome_tautomerase	18,42	COX-2	52,57	D-dopachrome tautomerase	COX-2	1652	4513	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	The MIF homologue D-dopachrome_tautomerase promotes COX-2 expression through b-catenin-dependent and - independent mechanisms .
22951300	0	D-dopachrome_tautomerase	0,24	IL-6	34,38	D-dopachrome tautomerase	IL-6	1652	3569	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	D-dopachrome_tautomerase promotes IL-6 expression and inhibits adipogenesis in preadipocytes .
10079069	0	D-dopachrome_tautomerase	27,51	macrophage_migration_inhibitory_factor	68,106	D-dopachrome tautomerase	macrophage migration inhibitory factor	1652	4282	Gene	Gene	structure|nmod|START_ENTITY structure|appos|homologue homologue|nmod|END_ENTITY	Crystal structure of human D-dopachrome_tautomerase , a homologue of macrophage_migration_inhibitory_factor , at 1.54 A resolution .
21817065	0	D-dopachrome_tautomerase	4,28	macrophage_migration_inhibitory_factor	88,126	D-dopachrome tautomerase	macrophage migration inhibitory factor	13202(Tax:10090)	17319(Tax:10090)	Gene	Gene	product|amod|START_ENTITY homolog|nsubj|product homolog|nmod|END_ENTITY	The D-dopachrome_tautomerase -LRB- DDT -RRB- gene product is a cytokine and functional homolog of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- .
24356968	0	D-dopachrome_tautomerase	13,37	macrophage_migration_inhibitory_factor	98,136	D-dopachrome tautomerase	macrophage migration inhibitory factor	1652	4282	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Dysregulated D-dopachrome_tautomerase , a hypoxia-inducible factor-dependent gene , cooperates with macrophage_migration_inhibitory_factor in renal tumorigenesis .
9034334	0	D-mef2	0,6	Tinman	23,29	D-mef2	Tinman	36032(Tax:7227)	42536(Tax:7227)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	D-mef2 is a target for Tinman activation during Drosophila heart development .
21832046	0	D-prostanoid_receptor	202,223	MUC5B	176,181	D-prostanoid receptor	MUC5B	5729	727897	Gene	Gene	signaling|compound|START_ENTITY expression|nmod|signaling expression|compound|END_ENTITY	The extracellular_signal-regulated_kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP_response_element-binding_protein to induce MUC5B gene expression via D-prostanoid_receptor signaling .
8786133	0	D-site_binding_protein	31,53	DBP	55,58	D-site binding protein	DBP	1628	1628	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure of the human D-site_binding_protein -LRB- DBP -RRB- gene .
21841820	0	D1/D3	37,42	lactadherin	7,18	D1/D3	lactadherin	13370;77337	17304(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MFG-E8 / lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells .
8449036	0	D17S811E	31,39	B2-1	20,24	D17S811E	B2-1	9267	9267	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of human B2-1 gene -LRB- D17S811E -RRB- to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization .
8876240	0	D1A	23,26	Brn-4	67,72	D1A	Brn-4	24316(Tax:10116)	29589(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of striatal D1A dopamine receptor gene transcription by Brn-4 .
24794748	0	D1_and_B1	104,113	c-Myc	86,91	D1 and B1	c-Myc	25802;7716	4609	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1_and_B1 mRNA and upregulation of p21 cell cycle inhibitor expression .
12149127	0	D1_and_D2	30,39	ERK	75,78	D1 and D2	ERK	25802	5594	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Involvement of phospholipases D1_and_D2 in sphingosine_1-phosphate-induced ERK -LRB- extracellular-signal-regulated_kinase -RRB- activation and interleukin-8 secretion in human bronchial epithelial cells .
9150381	0	D1_and_D3	32,41	p27Kip1	64,71	D1 and D3	p27Kip1	13370;226695	12576(Tax:10090)	Gene	Gene	control|nmod|START_ENTITY inhibitor|nsubj|control inhibitor|dobj|END_ENTITY	Differential control of cyclins D1_and_D3 and the cdk inhibitor p27Kip1 by diverse signalling pathways in Swiss_3T3 cells .
7637573	0	D1_receptor	88,99	c-fos	69,74	D1 receptor	c-fos	13488(Tax:10090)	14281(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY induction|nmod|activation induction|amod|END_ENTITY	Dopaminergic control of gene transcription during striatal ontogeny : c-fos induction by D1_receptor activation in the developing striosomes .
15944083	0	D2-like_dopamine_receptor	22,47	AmDOP3	49,55	D2-like dopamine receptor	AmDOP3	408995(Tax:7460)	408995(Tax:7460)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of a D2-like_dopamine_receptor -LRB- AmDOP3 -RRB- in honey_bee , Apis_mellifera .
9192856	0	D21S2056E	16,25	NNP-1	4,9	D21S2056E	NNP-1	8568	8568	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The NNP-1 gene -LRB- D21S2056E -RRB- , which encodes a novel nuclear protein , maps in close proximity to the cystatin_B gene within the EPM1 and APECED critical region on 21q22 .3 .
16766132	0	D2_dopamine_receptor	72,92	DRD2	94,98	D2 dopamine receptor	DRD2	1813	1813	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Heavy nicotine and alcohol use in alcohol dependence is associated with D2_dopamine_receptor -LRB- DRD2 -RRB- polymorphism .
17615493	0	D2_dopamine_receptor	0,20	DRD2	22,26	D2 dopamine receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	D2_dopamine_receptor -LRB- DRD2 -RRB- gene Taq1A polymorphism and the eating-related psychological_traits_in_eating_disorders -LRB- anorexia_nervosa_and_bulimia -RRB- and obesity .
9067310	0	D3	87,89	hD2	91,94	D3	hD2	1735	28503	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Interactions of -LRB- + -RRB- - _ and _ -LRB- - -RRB- -8 - _ and_7-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin at human -LRB- h -RRB- D3 , hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats .
8119149	0	D3_and_tumor_necrosis_factor-alpha	75,109	osteocalcin	121,132	D3 and tumor necrosis factor-alpha	osteocalcin	24835(Tax:10116)	81613(Tax:10116)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A single up-stream element confers responsiveness to 1,25-dihydroxyvitamin _ D3_and_tumor_necrosis_factor-alpha in the rat osteocalcin gene .
11673801	0	D3_receptor	9,20	DRD3	22,26	D3 receptor	DRD3	1814	1814	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Dopamine D3_receptor -LRB- DRD3 -RRB- gene polymorphism is associated with the intensity of eye movement_disturbances in schizophrenic patients and healthy subjects .
9399690	0	D4DR	73,77	dopamine_D4_receptor	51,71	D4DR	dopamine D4 receptor	1815	1815	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Additional evidence for an association between the dopamine_D4_receptor -LRB- D4DR -RRB- exon III repeat polymorphism and the human personality trait of Novelty_Seeking .
7944879	0	D4_dopamine_receptor	25,45	DRD4	47,51	D4 dopamine receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic variation in the D4_dopamine_receptor -LRB- DRD4 -RRB- gene does not predict response to clozapine .
16630611	0	DAAM1	30,35	RhoA	70,74	DAAM1	RhoA	208846(Tax:10090)	11848(Tax:10090)	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42 , CIP4 and Src in regulating cell morphogenesis and actin dynamics .
18378121	0	DAAO	38,42	D-amino_acid_oxidase	16,36	DAAO	D-amino acid oxidase	1610	1610	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Increased brain D-amino_acid_oxidase -LRB- DAAO -RRB- activity in schizophrenia .
18298590	0	DAB-1	95,100	ITSN-1	0,6	DAB-1	ITSN-1	174323(Tax:6239)	178491(Tax:6239)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1 .
23558076	0	DAB2IP	24,30	KRAS	67,71	DAB2IP	KRAS	153090	3845	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of DAB2IP in pancreatic_cancer with wild-type KRAS .
27036023	0	DAB2IP	21,27	Smurf1	0,6	DAB2IP	Smurf1	153090	57154	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Smurf1 regulation of DAB2IP controls cell proliferation and migration .
25841337	0	DAB2IP	78,84	miR-889	0,7	DAB2IP	miR-889	153090	100126345	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	miR-889 promotes proliferation of esophageal_squamous_cell_carcinomas through DAB2IP .
25454946	0	DAB2IP	98,104	p53	7,10	DAB2IP	p53	153090	7157	Gene	Gene	Interaction|nmod|START_ENTITY Reprograms|nmod|Interaction Reprograms|nsubj|END_ENTITY	Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP .
25583813	0	DAB2IP	56,62	p53	7,10	DAB2IP	p53	153090	7157	Gene	Gene	Modulates|nmod|START_ENTITY Modulates|nsubj|END_ENTITY	Mutant p53 Modulates TNF Signaling via Interaction with DAB2IP .
22902925	0	DACH1	58,63	C/EBPa	72,78	DACH1	C/EBPa	1602	1050	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
22902925	0	DACH1	58,63	HOXA9	14,19	DACH1	HOXA9	1602	3205	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
22902925	0	DACH1	58,63	MLL-AF9	115,122	DACH1	MLL-AF9	1602	4297	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
25322986	0	DACH1	0,5	cyclin_D1	15,24	DACH1	cyclin D1	1602	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	DACH1 inhibits cyclin_D1 expression , cellular proliferation and tumor growth of renal_cancer cells .
9144178	0	DAD1	0,4	oligosaccharyltransferase	79,104	DAD1	oligosaccharyltransferase	1603	1650	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	DAD1 , the defender against apoptotic cell death , is a subunit of the mammalian oligosaccharyltransferase .
10834315	0	DAF	65,68	CD55	70,74	DAF	CD55	1604	1604	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Porcine MCP gene promoter directs high level expression of human DAF -LRB- CD55 -RRB- in transgenic_mice .
11840345	0	DAF	16,19	CD55	21,25	DAF	CD55	1604	1604	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of DAF -LRB- CD55 -RRB- on orbital fibroblasts by cytokines .
11683962	0	DAF	72,75	decay-accelerating_factor	45,70	DAF	decay-accelerating factor	13136(Tax:10090)	13136(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Tissue distribution of products of the mouse decay-accelerating_factor -LRB- DAF -RRB- genes .
17098225	0	DAF-16	35,41	FTT-2	19,24	DAF-16	FTT-2	172981(Tax:6239)	181348(Tax:6239)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis_elegans .
21408062	0	DAF-16	21,27	HSF-1	61,66	DAF-16	HSF-1	172981(Tax:6239)	173078(Tax:6239)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Co-regulation of the DAF-16 target gene , cyp-35B1 / dod-13 , by HSF-1 in C. _ elegans dauer larvae and daf-2 insulin pathway mutants .
19874540	0	DAG1	16,20	AtGA3ox1	110,118	DAG1	AtGA3ox1	825358(Tax:3702)	838125(Tax:3702)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|regulating regulating|dobj|END_ENTITY	The Dof protein DAG1 mediates PIL5 activity on seed germination by negatively regulating GA biosynthetic gene AtGA3ox1 .
7607687	0	DAGK	63,67	diacylglycerol_kinase	40,61	DAGK	diacylglycerol kinase	110524(Tax:10090)	110524(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Chromosomal localization of three mouse diacylglycerol_kinase -LRB- DAGK -RRB- genes : genes sharing sequence homology to the Drosophila retinal_degeneration A -LRB- rdgA -RRB- gene .
8585934	0	DAGK3	59,64	diacylglycerol_kinase_3	34,57	DAGK3	diacylglycerol kinase 3	1608	1608	Gene	Gene	Localisation|appos|START_ENTITY Localisation|nmod|END_ENTITY	Localisation of the gene encoding diacylglycerol_kinase_3 -LRB- DAGK3 -RRB- to human chromosome 3q27-28 and mouse chromosome 16 .
12406557	0	DAM1	6,10	BLK	47,50	DAM1	BLK	17145(Tax:10090)	12143(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells .
11805835	0	DANCE	10,15	Fibulin-5	0,9	DANCE	Fibulin-5	23876(Tax:10090)	23876(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY END_ENTITY|parataxis|essential	Fibulin-5 / DANCE is essential for elastogenesis in vivo .
3111196	0	DAO	17,20	Diamine_oxidase	0,15	DAO	Diamine oxidase	26	26	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Diamine_oxidase -LRB- DAO -RRB- activity and intestinal mucosa integrity : influence of suture techniques .
2124560	0	DAO	38,41	diamine_oxidase	21,36	DAO	diamine oxidase	65029(Tax:10116)	65029(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of intestinal diamine_oxidase -LRB- DAO -RRB- depletion by heparin on mucosal polyamine metabolism .
2504567	0	DAO	49,52	diamine_oxidase	32,47	DAO	diamine oxidase	65029(Tax:10116)	65029(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Changes in serum and intestinal diamine_oxidase -LRB- DAO -RRB- activity after proximal enterectomy in rats .
2508450	0	DAO	29,32	diamine_oxidase	12,27	DAO	diamine oxidase	26	26	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Studies on diamine_oxidase -LRB- DAO -RRB- activity in seminal plasma -RSB- .
3134802	0	DAO	40,43	diamine_oxidase	23,38	DAO	diamine oxidase	26	26	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Large bowel tumors and diamine_oxidase -LRB- DAO -RRB- activity in patients : a new approach for risk group identification .
22454242	0	DAOA	37,41	D-amino_acid_oxidase_activator	0,30	DAOA	D-amino acid oxidase activator	267012	267012	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	D-amino_acid_oxidase_activator gene -LRB- DAOA -RRB- variation affects cerebrospinal fluid homovanillic_acid concentrations in healthy Caucasians .
9867351	0	DAP-2	0,5	AP-2	54,58	DAP-2	AP-2	40398(Tax:7227)	40398(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	DAP-2 , the Drosophila homolog of transcription factor AP-2 .
9032289	0	DAP-5	0,5	eukaryotic_translation_initiation_factor_4G	26,69	DAP-5	eukaryotic translation initiation factor 4G	1982	1981	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	DAP-5 , a novel homolog of eukaryotic_translation_initiation_factor_4G isolated as a putative modulator of gamma interferon-induced programmed cell death .
15729359	0	DAP-kinase	58,68	UNC5H2	24,30	DAP-kinase	UNC5H2	69635(Tax:10090)	107449(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase .
19625447	0	DAP-like_kinase	43,58	Par-4	0,5	DAP-like kinase	Par-4	64391(Tax:10116)	64513(Tax:10116)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Par-4 is an essential downstream target of DAP-like_kinase -LRB- Dlk -RRB- in Dlk/Par -4 - mediated apoptosis .
20818178	0	DAP1	24,28	mTOR	38,42	DAP1	mTOR	1611	21977(Tax:10090)	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Autophagy gets a brake : DAP1 , a novel mTOR substrate , is activated to suppress the autophagic process .
20484116	0	DAP10	55,60	PI3K	41,45	DAP10	PI3K	10870	5293	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|activation activation|nmod|END_ENTITY	TREM2 - and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1 .
21659545	0	DAP12	42,47	Btk	0,3	DAP12	Btk	7305	695	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Btk is a positive regulator in the TREM-1 / DAP12 signaling pathway .
18192027	0	DAP12	11,16	TREM-1	4,10	DAP12	TREM-1	7305	54210	Gene	Gene	pathway|nummod|START_ENTITY END_ENTITY|dep|pathway	The TREM-1 / DAP12 pathway .
15302871	0	DAP3	47,51	death-associated_protein_3	19,45	DAP3	death-associated protein 3	7818	7818	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Functional role of death-associated_protein_3 -LRB- DAP3 -RRB- in anoikis .
25779044	0	DAP5	0,4	eIF2b	21,26	DAP5	eIF2b	1982	8894	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	DAP5 associates with eIF2b and eIF4AI to promote Internal Ribosome Entry Site driven translation .
21345788	0	DAPIT	13,18	diabetes-associated_protein_in_insulin-sensitive_tissue	20,75	DAPIT	diabetes-associated protein in insulin-sensitive tissue	84833	84833	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Knockdown of DAPIT -LRB- diabetes-associated_protein_in_insulin-sensitive_tissue -RRB- results in loss of ATP synthase in mitochondria .
22490852	0	DAPK	43,47	Death-associated_protein_kinase	1,32	DAPK	Death-associated protein kinase	1612	1612	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	-LSB- Death-associated_protein_kinase promoter -LRB- DAPK -RRB- hypermethylation in uterine cervical_cancer and intraepithelial_neoplasia in Uyghur nationality women -RSB- .
17803936	0	DAPK	21,25	Src	71,74	DAPK	Src	1612	6714	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR .
17056602	0	DAPK	44,48	death-associated_protein_kinase	11,42	DAPK	death-associated protein kinase	1612	1612	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Control of death-associated_protein_kinase -LRB- DAPK -RRB- activity by phosphorylation and proteasomal degradation .
23806751	0	DAPK	45,49	death-associated_protein_kinase	12,43	DAPK	death-associated protein kinase	1612	1612	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of death-associated_protein_kinase -LRB- DAPK -RRB- in endothelial apoptosis under fluid shear stress .
26191186	0	DAPK1	112,117	MiR-191	0,7	DAPK1	MiR-191	1612	406966	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-191 inhibits TNF-a induced apoptosis of ovarian_endometriosis and endometrioid_carcinoma cells by targeting DAPK1 .
26473357	0	DARC	115,119	Duffy_Antigen_Receptor_for_Chemokines	76,113	DARC	Duffy Antigen Receptor for Chemokines	2532	2532	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Distinct Transcript Isoforms of the Atypical_Chemokine_Receptor_1 -LRB- ACKR1 -RRB- / Duffy_Antigen_Receptor_for_Chemokines -LRB- DARC -RRB- Gene Are Expressed in Lymphoblasts and Altered Isoform Levels Are Associated with Genetic Ancestry and the Duffy-Null Allele .
21156192	0	DARC	41,45	Duffy_antigen_receptor_for_chemokines	2,39	DARC	Duffy antigen receptor for chemokines	2532	2532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	A Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- polymorphism that determines pro-fibrotic chemokine serum concentrations is not directly associated with severity of hepatitis_C infection .
26045319	0	DARC	71,75	Duffy_antigen_receptor_for_chemokines	32,69	DARC	Duffy antigen receptor for chemokines	2532	2532	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Lack of association between the Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- expression and clinical outcome of children with sickle_cell_anemia .
26096170	0	DARC	53,57	Duffy_antigen_receptor_for_chemokines	14,51	DARC	Duffy antigen receptor for chemokines	2532	2532	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- is down-regulated in colorectal_cancer .
16862154	0	DARC	40,44	KAI1	15,19	DARC	KAI1	2532	3732	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression .
21088296	0	DARC	123,127	duffy_antigen_receptor_for_chemokines	84,121	DARC	duffy antigen receptor for chemokines	2532	2532	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Activation state of alpha4beta1 integrin on sickle red blood cells is linked to the duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- expression .
9428587	0	DARP	45,49	dopamine-releasing_protein	17,43	DARP	dopamine-releasing protein	200539	200539	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of dopamine-releasing_protein -LRB- DARP -RRB- in cerebrospinal fluid of patients with neurological_disorders .
17209049	0	DARPP-32	72,80	AKT	0,3	DARPP-32	AKT	84152	207	Gene	Gene	induction|nmod|START_ENTITY mediate|dobj|induction mediate|nsubj|END_ENTITY	AKT and CDK5/p35 mediate brain-derived_neurotrophic_factor induction of DARPP-32 in medium size spiny neurons in vitro .
25779598	0	DARPP-32	44,52	ANGPT2	23,29	DARPP-32	ANGPT2	84152	285	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Gastric_tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis .
9200733	0	DARPP-32	62,70	Brain-derived_neurotrophic_factor	0,33	DARPP-32	Brain-derived neurotrophic factor	19049(Tax:10090)	12064(Tax:10090)	Gene	Gene	phenotype|compound|START_ENTITY maturation|nmod|phenotype regulates|dobj|maturation regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons : studies in vivo and in vitro .
15066157	0	DARPP-32	150,158	Cdk5	127,131	DARPP-32	Cdk5	360616(Tax:10116)	140908(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Repeated acetyl-l-carnitine administration increases phospho-Thr34 DARPP-32 levels and antagonizes cocaine-induced increase in Cdk5 and phospho-Thr75 DARPP-32 levels in rat striatum .
22593050	0	DARPP-32	14,22	Egr-1	0,5	DARPP-32	Egr-1	360616(Tax:10116)	24330(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element .
12064480	0	DARPP-32	22,30	Neurotensin	0,11	DARPP-32	Neurotensin	19049(Tax:10090)	67405(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors .
23459765	0	DARPP-32	20,28	PPP1R1B	11,18	DARPP-32	PPP1R1B	84152	84152	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Effects of PPP1R1B -LRB- DARPP-32 -RRB- Polymorphism on Feedback-Related Brain Potentials Across the Life Span .
16026464	0	DARPP-32	39,47	RARbeta	0,7	DARPP-32	RARbeta	360616(Tax:10116)	24706(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	RARbeta isoform-specific regulation of DARPP-32 gene expression : an ectopic expression study in the developing rat telencephalon .
17209049	0	DARPP-32	72,80	brain-derived_neurotrophic_factor	25,58	DARPP-32	brain-derived neurotrophic factor	84152	627	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	AKT and CDK5/p35 mediate brain-derived_neurotrophic_factor induction of DARPP-32 in medium size spiny neurons in vitro .
9483560	0	DARPP-32	74,82	glutamate_decarboxylase	106,129	DARPP-32	glutamate decarboxylase	84152	2752	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	The dopaminergic innervation of the pigeon telencephalon : distribution of DARPP-32 and co-occurrence with glutamate_decarboxylase and tyrosine_hydroxylase .
11739615	0	DARPP-32	84,92	phosphatidylinositide_3-kinase	8,38	DARPP-32	phosphatidylinositide 3-kinase	84152	5293	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Role of phosphatidylinositide_3-kinase in brain-derived_neurotrophic_factor-induced DARPP-32 expression in medium size spiny neurons in vitro .
10898909	0	DAT	68,71	DRD4	36,40	DAT	DRD4	6531	1815	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Investigation of dopamine receptor -LRB- DRD4 -RRB- and dopamine_transporter -LRB- DAT -RRB- polymorphisms for genetic linkage or association to panic_disorder .
17171650	0	DAT	70,73	SLC6A3	80,86	DAT	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Dopaminergic polymorphisms in Tourette_syndrome : association with the DAT gene -LRB- SLC6A3 -RRB- .
21291984	0	DAT	77,80	VMAT_2	70,76	DAT	VMAT 2	24898(Tax:10116)	25549(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Protective effect of Zhen-Wu-Tang -LRB- ZWT -RRB- through keeping DA stable and VMAT_2 / DAT mRNA in balance in rats with striatal lesions induced by MPTP .
16490314	0	DAT	54,57	dopamine_transporter	33,53	DAT	dopamine transporter	6531	6531	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the neuronal dopamine_transporter DAT in human blood platelets .
16733058	0	DAT	30,33	dopamine_transporter	8,28	DAT	dopamine transporter	788410(Tax:9913)	788410(Tax:9913)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of dopamine_transporter -LRB- DAT -RRB- in dopamine transport across the nasal mucosa .
19960520	0	DAT	38,41	dopamine_transporter	16,36	DAT	dopamine transporter	6531	6531	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the dopamine_transporter -LRB- DAT -RRB- in the development of PTSD in preschool children .
23065263	0	DAT1	114,118	BDNF	82,86	DAT1	BDNF	6531	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	DNA methylation and expression profiles of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and dopamine_transporter -LRB- DAT1 -RRB- genes in patients with schizophrenia .
26729744	0	DAT1	68,72	Dopamine_Transporter	41,61	DAT1	Dopamine Transporter	6531	6531	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Gene-Environment Correlation Between the Dopamine_Transporter Gene -LRB- DAT1 -RRB- Polymorphism and Childhood Experiences of Abuse .
11942948	0	DAT1	27,31	Dopamine_transporter	0,20	DAT1	Dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_transporter gene -LRB- DAT1 -RRB- VNTR polymorphism in major psychiatric_disorders : family-based association study in the Bulgarian population .
17314918	0	DAT1	27,31	Dopamine_transporter	0,20	DAT1	Dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_transporter gene -LRB- DAT1 -RRB- associated with appetite suppression to methylphenidate in a case-control study of binge_eating_disorder .
20450954	0	DAT1	24,28	SLC6A3	16,22	DAT1	SLC6A3	6531	6531	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Variants of the SLC6A3 -LRB- DAT1 -RRB- polymorphism affect performance monitoring-related cortical evoked potentials that are associated with ADHD .
10889530	0	DAT1	109,113	dopamine_transporter	82,102	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Systematic screening for DNA sequence variation in the coding region of the human dopamine_transporter gene -LRB- DAT1 -RRB- .
11911442	0	DAT1	57,61	dopamine_transporter	35,55	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The VNTR polymorphism of the human dopamine_transporter -LRB- DAT1 -RRB- gene affects gene expression .
1478653	0	DAT1	33,37	dopamine_transporter	6,26	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human dopamine_transporter gene -LRB- DAT1 -RRB- maps to chromosome 5p15 .3 and displays a VNTR .
15683546	0	DAT1	94,98	dopamine_transporter	67,87	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transient expression analysis of allelic variants of a VNTR in the dopamine_transporter gene -LRB- DAT1 -RRB- .
15749835	0	DAT1	188,192	dopamine_transporter	166,186	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3 ' non-coding polymorphic region of the human dopamine_transporter -LRB- DAT1 -RRB- gene .
16123773	0	DAT1	42,46	dopamine_transporter	20,40	DAT1	dopamine transporter	6531	6531	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between dopamine_transporter -LRB- DAT1 -RRB- genotype , left-sided inattention , and an enhanced response to methylphenidate in attention-deficit_hyperactivity_disorder .
16702979	0	DAT1	61,65	dopamine_transporter	39,59	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A 40-basepair VNTR polymorphism in the dopamine_transporter -LRB- DAT1 -RRB- gene and the rapid response to antidepressant treatment .
17712789	0	DAT1	91,95	dopamine_transporter	64,84	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Diversity and relationship between Iranian ethnic groups : human dopamine_transporter gene -LRB- DAT1 -RRB- VNTR genotyping .
19120712	0	DAT1	66,70	dopamine_transporter	44,64	DAT1	dopamine transporter	6531	6531	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of ADHD , tics , and anxiety with dopamine_transporter -LRB- DAT1 -RRB- genotype in autism_spectrum_disorder .
19352220	0	DAT1	83,87	dopamine_transporter	61,81	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between harmful alcohol consumption behavior and dopamine_transporter -LRB- DAT1 -RRB- gene polymorphisms in a male Finnish population .
20141587	0	DAT1	31,35	dopamine_transporter	4,24	DAT1	dopamine transporter	6531	6531	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The dopamine_transporter gene -LRB- DAT1 -RRB- polymorphism is associated with premature_ejaculation .
22564179	0	DAT1	107,111	dopamine_transporter	80,100	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Double dissociation between lab measures of inattention and impulsivity and the dopamine_transporter gene -LRB- DAT1 -RRB- and dopamine_D4_receptor gene -LRB- DRD4 -RRB- .
22646917	0	DAT1	37,41	dopamine_transporter	15,35	DAT1	dopamine transporter	6531	6531	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of dopamine_transporter -LRB- DAT1 -RRB- genotype and maltreatment for ADHD : a latent class analysis .
22819977	0	DAT1	76,80	dopamine_transporter	54,74	DAT1	dopamine transporter	6531	6531	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	The androgen_receptor facilitates inhibition of human dopamine_transporter -LRB- DAT1 -RRB- reporter gene expression by HESR1 and HESR2 via the variable number of tandem repeats .
24432029	0	DAT1	77,81	dopamine_transporter	55,75	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The presence of both serotonin 1A receptor -LRB- HTR1A -RRB- and dopamine_transporter -LRB- DAT1 -RRB- gene variants increase the risk of borderline_personality_disorder .
25915480	0	DAT1	51,55	dopamine_transporter	24,44	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between the dopamine_transporter gene -LRB- DAT1 -RRB- and attention_deficit_hyperactivity_disorder-related traits in healthy adults .
25915480	0	DAT1	51,55	dopamine_transporter	24,44	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between the dopamine_transporter gene -LRB- DAT1 -RRB- and attention_deficit_hyperactivity_disorder-related traits in healthy adults .
7557351	0	DAT1	65,69	dopamine_transporter	38,58	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Population genetic study of the human dopamine_transporter gene -LRB- DAT1 -RRB- .
7590757	0	DAT1	17,21	dopamine_transporter	29,49	DAT1	dopamine transporter	6531	6531	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Amplification of DAT1 -LRB- human dopamine_transporter gene -RRB- 3 ' variable region in the Japanese population .
9433566	0	DAT1	62,66	dopamine_transporter	35,55	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Linkage disequilibrium between the dopamine_transporter gene -LRB- DAT1 -RRB- and bipolar_disorder : extending the transmission disequilibrium test -LRB- TDT -RRB- to examine genetic heterogeneity .
20218802	0	DAT1	77,81	serotonin_5-HT2A_receptor	20,45	DAT1	serotonin 5-HT2A receptor	6531	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interaction between serotonin_5-HT2A_receptor gene and dopamine_transporter -LRB- DAT1 -RRB- gene polymorphisms influences personality trait of persistence in Austrian Caucasians .
16314306	0	DAX-1	59,64	ERRgamma	108,116	DAX-1	ERRgamma	190	2104	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma .
9566914	0	DAX-1	17,22	N-CoR	61,66	DAX-1	N-CoR	11614(Tax:10090)	20185(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1 .
18716981	0	DAX-1	91,96	NR0B1	84,89	DAX-1	NR0B1	190	190	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Extreme hyponatremia in an infant with congenital_adrenal_hypoplasia due to a novel NR0B1 -LRB- DAX-1 -RRB- mutation .
21227944	0	DAX-1	112,117	NR0B1	119,124	DAX-1	NR0B1	190	190	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Birth after TESE-ICSI in a man with hypogonadotropic_hypogonadism and congenital_adrenal_hypoplasia linked to a DAX-1 -LRB- NR0B1 -RRB- mutation .
18941128	0	DAX-1	81,86	NROB1	74,79	DAX-1	NROB1	190	190	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Three cases of congenital_adrenal_hypoplasia with novel mutations in the -LRB- NROB1 -RRB- DAX-1 gene .
21378322	0	DAX-1	52,57	NROB1	59,64	DAX-1	NROB1	190	190	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The prognostic value of the orphan nuclear receptor DAX-1 -LRB- NROB1 -RRB- in node-negative breast_cancer .
15155786	0	DAX-1	37,42	Nur77	82,87	DAX-1	Nur77	11614(Tax:10090)	15370(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation .
8921887	0	DAX1	29,33	Ahch	0,4	DAX1	Ahch	11614(Tax:10090)	11614(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Ahch , the mouse homologue of DAX1 : cloning , characterization and synteny with GyK , the glycerol kinase locus .
15841486	0	DAX1	39,43	NR0B1	32,37	DAX1	NR0B1	190	190	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Thirteen novel mutations in the NR0B1 -LRB- DAX1 -RRB- gene as cause of adrenal_hypoplasia_congenita .
16355812	0	DAX1	32,36	NR0B1	38,43	DAX1	NR0B1	190	190	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel deletion mutations of the DAX1 -LRB- NR0B1 -RRB- gene in two Taiwanese families with X-linked adrenal_hypoplasia_congenita .
16709599	0	DAX1	104,108	NR0B1	111,116	DAX1	NR0B1	190	190	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Dosage-sensitive sex reversal adrenal_hypoplasia_congenita critical region on the X chromosome , gene 1 -LRB- DAX1 -RRB- -LRB- NR0B1 -RRB- and small_heterodimer_partner -LRB- SHP -RRB- -LRB- NR0B2 -RRB- form homodimers individually , as well as DAX1-SHP heterodimers .
19773398	0	DAX1	161,165	NR0B1	154,159	DAX1	NR0B1	190	190	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	X-linked congenital adrenal_hypoplasia_with_hypogonadotropic_hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 -LRB- DAX1 -RRB- gene .
25079468	0	DAX1	31,35	NR0B1	24,29	DAX1	NR0B1	190	190	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel mutation in the NR0B1 -LRB- DAX1 -RRB- gene in a large family with two boys affected by congenital_adrenal_hypoplasia .
24232823	0	DAX1	43,47	NROB1	36,41	DAX1	NROB1	190	190	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Mild adrenal_insufficiency due to a NROB1 -LRB- DAX1 -RRB- gene mutation in a boy presenting an association of hypogonadotropic_hypogonadism , reduced final height and attention_deficit_disorder .
15016915	0	DAXX	0,4	heat_shock_factor_1	20,39	DAXX	heat shock factor 1	1616	3297	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DAXX interacts with heat_shock_factor_1 during stress activation and enhances its transcriptional activity .
25659035	0	DAXX	48,52	p53	54,57	DAXX	p53	1616	7157	Gene	Gene	kinase|compound|START_ENTITY kinase|dep|END_ENTITY	DNA damage-induced regulatory interplay between DAXX , p53 , ATM kinase and Wip1 phosphatase .
10484770	0	DAZ	21,24	Deleted_in_AZoospermia	26,48	DAZ	Deleted in AZoospermia	1617	1617	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Old World monkey DAZ -LRB- Deleted_in_AZoospermia -RRB- gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome .
23055411	0	DAZ	81,84	Deleted_in_AZoospermia	86,108	DAZ	Deleted in AZoospermia	100286803(Tax:9544)	100286803(Tax:9544)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Sequencing of rhesus_macaque Y chromosome clarifies origins and evolution of the DAZ -LRB- Deleted_in_AZoospermia -RRB- genes .
9091344	0	DAZ	58,61	Deleted_in_AZoospermia	63,85	DAZ	Deleted in AZoospermia	1617	1617	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Screening for deletions of the Y chromosome involving the DAZ -LRB- Deleted_in_AZoospermia -RRB- gene in azoospermia and severe oligozoospermia .
9557839	0	DAZ	0,3	Deleted_in_AZoospermia	5,27	DAZ	Deleted in AZoospermia	1617	1617	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	DAZ -LRB- Deleted_in_AZoospermia -RRB- genes encode proteins located in human late spermatids and in sperm tails .
12511597	0	DAZ	87,90	Pumilio-2	6,15	DAZ	Pumilio-2	1617	23369	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ -LRB- Deleted in AZoospermia -RRB- and DAZ-like proteins .
16678151	0	DAZ-1	32,37	CPB-3	11,16	DAZ-1	CPB-3	173931(Tax:6239)	172244(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	C. _ elegans CPB-3 interacts with DAZ-1 and functions in multiple steps of germline development .
18669443	0	DAZAP1	0,6	hnRNP	11,16	DAZAP1	hnRNP	70248(Tax:10090)	56258(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	DAZAP1 , an hnRNP protein , is required for normal growth and spermatogenesis in mice .
16884537	0	DAZL	61,65	Deleted-in-AZoospermia-Like	32,59	DAZL	Deleted-in-AZoospermia-Like	1618	1618	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel missense mutations of the Deleted-in-AZoospermia-Like -LRB- DAZL -RRB- gene in infertile women and men .
19281782	0	DAZL	108,112	Deleted_in_Azoospermia-Like	79,106	DAZL	Deleted in Azoospermia-Like	1618	1618	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An epigenetic mechanism regulates germ cell-specific expression of the porcine Deleted_in_Azoospermia-Like -LRB- DAZL -RRB- gene .
11442633	0	DAlk	39,43	RTK	77,80	DAlk	RTK	53425(Tax:7227)	38559(Tax:7227)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification and characterization of DAlk : a novel Drosophila_melanogaster RTK which drives ERK activation in vivo .
7682582	0	DBA/2	92,97	HLA/A24	98,105	DBA/2	HLA/A24	114086	53599(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Abrogation of H-2-restricted CTL responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice .
26617872	0	DBC1	5,9	CCAR2	11,16	DBC1	CCAR2	57805	57805	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	High DBC1 -LRB- CCAR2 -RRB- expression in gallbladder_carcinoma is associated with favorable clinicopathological factors .
26060310	0	DBC1	75,79	FOXP3	34,39	DBC1	FOXP3	56710(Tax:10090)	20371(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1 .
21030595	0	DBC1	53,57	HDAC3	0,5	DBC1	HDAC3	56710(Tax:10090)	15183(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	HDAC3 is negatively regulated by the nuclear protein DBC1 .
24824780	0	DBC1	67,71	MCC	0,3	DBC1	MCC	56710(Tax:10090)	328949(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm .
18235501	0	DBC1	0,4	SIRT1	32,37	DBC1	SIRT1	57805	23411	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	DBC1 is a negative regulator of SIRT1 .
18235502	0	DBC1	48,52	SIRT1	39,44	DBC1	SIRT1	57805	23411	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of the deacetylase SIRT1 by DBC1 .
22553202	0	DBC1	36,40	SIRT1	53,58	DBC1	SIRT1	57805	23411	Gene	Gene	protein|appos|START_ENTITY protein|nmod|activation activation|compound|END_ENTITY	Role of deleted_in_breast_cancer_1 -LRB- DBC1 -RRB- protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase .
22735644	0	DBC1	0,4	SIRT1	41,46	DBC1	SIRT1	57805	23411	Gene	Gene	phosphorylation|nummod|START_ENTITY inhibits|nsubj|phosphorylation inhibits|dobj|deacetylase deacetylase|nummod|END_ENTITY	DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage .
23162614	0	DBC1	0,4	SIRT1	50,55	DBC1	SIRT1	57805	23411	Gene	Gene	function|nsubj|START_ENTITY function|nmod|regulator regulator|nmod|END_ENTITY	DBC1 does not function as a negative regulator of SIRT1 in liver_cancer .
23892437	0	DBC1	35,39	SIRT1	12,17	DBC1	SIRT1	57805	23411	Gene	Gene	binding|compound|START_ENTITY block|dobj|binding inhibitors|xcomp|block inhibitors|nsubj|END_ENTITY	Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism .
25146318	0	DBC1	62,66	SIRT1	0,5	DBC1	SIRT1	57805	23411	Gene	Gene	associated|nsubjpass|START_ENTITY associated|advcl|associated associated|nsubjpass|expression expression|compound|END_ENTITY	SIRT1 expression is associated with a poor prognosis , whereas DBC1 is associated with favorable outcomes in gastric_cancer .
22553202	0	DBC1	36,40	deleted_in_breast_cancer_1	8,34	DBC1	deleted in breast cancer 1	57805	57805	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Role of deleted_in_breast_cancer_1 -LRB- DBC1 -RRB- protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase .
12555232	0	DBH	27,30	Dopamine_beta-hydroxylase	0,25	DBH	Dopamine beta-hydroxylase	1621	1621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_beta-hydroxylase -LRB- DBH -RRB- gene and schizophrenia phenotypic variability : a genetic association study .
17853400	0	DBH	27,30	Dopamine_beta-hydroxylase	0,25	DBH	Dopamine beta-hydroxylase	1621	1621	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dopamine_beta-hydroxylase -LRB- DBH -RRB- activity and -1021 C/T polymorphism of DBH gene in combat-related post-traumatic_stress_disorder .
3498935	0	DBH	52,55	corticotropin-releasing_factor	10,40	DBH	corticotropin-releasing factor	25699(Tax:10116)	81648(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of corticotropin-releasing_factor on adrenal DBH and PNMT activity .
6764083	0	DBH	34,37	dopamine-beta-hydroxylase	7,32	DBH	dopamine-beta-hydroxylase	103347199	103347199	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Plasma dopamine-beta-hydroxylase -LRB- DBH -RRB- activity in two kinds of acute stress in rabbits .
20827341	0	DBH	108,111	dopamine_b-hydroxylase	84,106	DBH	dopamine b-hydroxylase	25699(Tax:10116)	25699(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase -LRB- TH -RRB- and dopamine_b-hydroxylase -LRB- DBH -RRB- gene expression in immobilization-stressed rats and PC12 cells .
10490716	0	DBH	128,131	dopamine_beta-hydroxylase	96,121	DBH	dopamine beta-hydroxylase	1621	1621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No evidence for allelic association between schizophrenia and a functional variant of the human dopamine_beta-hydroxylase gene -LRB- DBH -RRB- .
729170	0	DBH	33,36	dopamine_beta-hydroxylase	6,31	DBH	dopamine beta-hydroxylase	1621	1621	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Serum dopamine_beta-hydroxylase -LRB- DBH -RRB- activity in acute myocardial_infarction .
9259372	0	DBH	83,86	dopamine_beta-hydroxylase	51,76	DBH	dopamine beta-hydroxylase	1621	1621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Population genetics of a functional variant of the dopamine_beta-hydroxylase gene -LRB- DBH -RRB- .
3180847	0	DBH	53,56	dopamine_beta_hydroxylase	26,51	DBH	dopamine beta hydroxylase	1621	1621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human dopamine_beta_hydroxylase -LRB- DBH -RRB- gene to chromosome 9q34 .
22888292	0	DBH	75,78	tyrosine_hydroxylase	21,41	DBH	tyrosine hydroxylase	280758(Tax:9913)	280707(Tax:9913)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Genetic diversity of tyrosine_hydroxylase -LRB- TH -RRB- and dopamine_b-hydroxylase -LRB- DBH -RRB- genes in cattle breeds .
1652780	0	DBI	88,91	diazepam-binding_inhibitor	60,86	DBI	diazepam-binding inhibitor	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of peripheral benzodiazepine binding sites and diazepam-binding_inhibitor -LRB- DBI -RRB- mRNA in mammary glands and dimethylbenz -LRB- a -RRB- antracene -LRB- DMBA -RRB- - induced mammary_tumors in the rat .
1791923	0	DBI	44,47	diazepam-binding_inhibitor	16,42	DBI	diazepam-binding inhibitor	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of diazepam-binding_inhibitor -LRB- DBI -RRB- mRNA in the rat brain by high resolution in situ hybridization .
11288485	0	DBI	64,67	diazepam_binding_inhibitor	36,62	DBI	diazepam binding inhibitor	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	-LSB- Functional involvement of cerebral diazepam_binding_inhibitor -LRB- DBI -RRB- in the establishment of drug_dependence -RSB- .
11704264	0	DBI	38,41	diazepam_binding_inhibitor	10,36	DBI	diazepam binding inhibitor	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of diazepam_binding_inhibitor -LRB- DBI -RRB- on the fluid intake , preference and the taste reactivity in mice .
11757913	0	DBI	57,60	diazepam_binding_inhibitor	29,55	DBI	diazepam binding inhibitor	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cellular localization of the diazepam_binding_inhibitor -LRB- DBI -RRB- in the gastrointestinal tract of mice and its coexistence with the fatty_acid binding protein -LRB- FABP -RRB- .
14755437	0	DBI	63,66	diazepam_binding_inhibitor	35,61	DBI	diazepam binding inhibitor	1622	1622	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Multiple missense mutations in the diazepam_binding_inhibitor -LRB- DBI -RRB- gene identified in schizophrenia but lack of disease association .
1723508	0	DBI	69,72	diazepam_binding_inhibitor	41,67	DBI	diazepam binding inhibitor	1622	1622	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Electrophysiological characterization of diazepam_binding_inhibitor -LRB- DBI -RRB- on GABAA receptors .
2171047	0	DBI	65,68	diazepam_binding_inhibitor	37,63	DBI	diazepam binding inhibitor	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and characterization of diazepam_binding_inhibitor -LRB- DBI -RRB- in peripheral tissues of rat .
7913213	0	DBI	47,50	diazepam_binding_inhibitor	19,45	DBI	diazepam binding inhibitor	1622	1622	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Nicotine increases diazepam_binding_inhibitor -LRB- DBI -RRB- mRNA in primary cultured neurons .
8396705	0	DBI	78,81	diazepam_binding_inhibitor	50,76	DBI	diazepam binding inhibitor	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	ACTH-induced mitochondrial DBI receptor -LRB- MDR -RRB- and diazepam_binding_inhibitor -LRB- DBI -RRB- expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action .
8529966	0	DBI	56,59	diazepam_binding_inhibitor	28,54	DBI	diazepam binding inhibitor	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	-LSB- Functional significance of diazepam_binding_inhibitor -LRB- DBI -RRB- in establishment of alcohol_dependence -RSB- .
8750843	0	DBI	47,50	diazepam_binding_inhibitor	19,45	DBI	diazepam binding inhibitor	1622	1622	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Ethanol stimulates diazepam_binding_inhibitor -LRB- DBI -RRB- mRNA expression in primary cultured neurons .
9613098	0	DBI	55,58	diazepam_binding_inhibitor	27,53	DBI	diazepam binding inhibitor	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	-LSB- Functional involvement of diazepam_binding_inhibitor -LRB- DBI -RRB- in the establishment of drug_dependence -RSB- .
10864461	0	DBL-1	50,55	SMA-6	56,61	DBL-1	SMA-6	179068(Tax:6239)	174044(Tax:6239)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	SMA-3 smad has specific and critical functions in DBL-1 / SMA-6 TGFbeta-related signaling .
22303001	0	DBNL	48,52	Abp1	42,46	DBNL	Abp1	28988	28988	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Src-mediated phosphorylation of mammalian Abp1 -LRB- DBNL -RRB- regulates podosome rosette formation in transformed fibroblasts .
8786133	0	DBP	55,58	D-site_binding_protein	31,53	DBP	D-site binding protein	1628	1628	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure of the human D-site_binding_protein -LRB- DBP -RRB- gene .
17449080	0	DBP	46,49	DNA-binding_protein	51,70	DBP	DNA-binding protein	284390	284390	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of a baculovirus lacking the DBP -LRB- DNA-binding_protein -RRB- gene .
21458520	0	DBP	33,36	Kiss1	61,66	DBP	Kiss1	24309(Tax:10116)	289023(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Circadian transcriptional factor DBP regulates expression of Kiss1 in the anteroventral periventricular nucleus .
16868893	0	DBP	27,30	Vitamin_D-binding_protein	0,25	DBP	Vitamin D-binding protein	1628	2638	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Vitamin_D-binding_protein -LRB- DBP -RRB- gene polymorphism is associated with Graves ' _ disease and the vitamin_D status in a Polish population study .
12968673	0	DBP	118,121	vitamin_D-binding_protein	91,116	DBP	vitamin D-binding protein	1628	2638	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of molecular variants , haplotypes , and linkage disequilibrium within the human vitamin_D-binding_protein -LRB- DBP -RRB- gene with postmenopausal bone_mineral_density .
24481677	0	DBZ	0,3	DISC1	20,25	DBZ	DISC1	216049(Tax:10090)	244667(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	DBZ , a CNS-specific DISC1 binding protein , positively regulates oligodendrocyte differentiation .
12474232	0	DC-Lamp	36,43	CCL19	27,32	DC-Lamp	CCL19	27074	6363	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential expression of CCL19 by DC-Lamp + mature dendritic cells in human lymph node versus chronically inflamed skin .
25663546	0	DC-SCRIPT	0,9	CDKN2B	60,66	DC-SCRIPT	CDKN2B	167465	1030	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERa-positive breast_cancer cells .
23440419	0	DC-SCRIPT	0,9	GILZ	82,86	DC-SCRIPT	GILZ	167465	1831	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	DC-SCRIPT regulates glucocorticoid_receptor function and expression of its target GILZ in dendritic cells .
26170389	0	DC-SCRIPT	0,9	IL-10	20,25	DC-SCRIPT	IL-10	167465	3586	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-kBp65 Activation .
21081145	0	DC-SIGN	37,44	CD209	46,51	DC-SIGN	CD209	30835	30835	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relationship between polymorphism of DC-SIGN -LRB- CD209 -RRB- gene and the susceptibility to pulmonary_tuberculosis in an eastern Chinese population .
26837416	0	DC-SIGN	19,26	Gp120	0,5	DC-SIGN	Gp120	30835	155971(Tax:11676)	Gene	Gene	binding|nmod|START_ENTITY binding|advmod|END_ENTITY	Gp120 binding with DC-SIGN induces reactivation of HIV-1 provirus via the NF-kB signaling pathway .
12594843	0	DC-SIGN	24,31	IL-18	38,43	DC-SIGN	IL-18	30835	3606	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased expression of DC-SIGN + IL-12 + IL-18 + and CD83 + IL-12-IL-18 - dendritic cell populations in the colonic mucosa of patients with Crohn 's _ disease .
19942750	0	DC-SIGN	22,29	MCP-1	6,11	DC-SIGN	MCP-1	30835	6347	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|dep|END_ENTITY	CCR2 , MCP-1 , SDF-1a _ DC-SIGN gene polymorphisms in HIV-1 infected patients with _ without tuberculosis .
19879650	0	DC-SIGN	77,84	dendritic_cell-specific_ICAM-3-grabbing_non-integrin	23,75	DC-SIGN	dendritic cell-specific ICAM-3-grabbing non-integrin	30835	30835	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Epitope mapping on the dendritic_cell-specific_ICAM-3-grabbing_non-integrin -LRB- DC-SIGN -RRB- pathogen-attachment factor .
20667443	0	DC-SIGN	77,84	dendritic_cell-specific_ICAM-3-grabbing_nonintegrin	24,75	DC-SIGN	dendritic cell-specific ICAM-3-grabbing nonintegrin	30835	30835	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	An assay for functional dendritic_cell-specific_ICAM-3-grabbing_nonintegrin -LRB- DC-SIGN -RRB- inhibitors of human dendritic_cell_adhesion .
17522223	0	DC-SIGN	30,37	gp120	90,95	DC-SIGN	gp120	30835	155971(Tax:11676)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Identification of the optimal DC-SIGN binding site on human_immunodeficiency_virus_type_1 gp120 .
20546900	0	DC-STAMP	0,8	LUMAN	57,62	DC-STAMP	LUMAN	81501	10488	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation .
26503158	0	DC-STAMP	66,74	Luman	0,5	DC-STAMP	Luman	81501	10488	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression involved|nmod|regulation involved|nsubjpass|END_ENTITY	Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression , stability and localization .
18952287	0	DC-STAMP	19,27	OS9	0,3	DC-STAMP	OS9	81501	10956	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation .
25061874	0	DCBLD2	24,30	EGFR	0,4	DCBLD2	EGFR	131566	1956	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis .
21957262	0	DCC	61,64	Draxin	0,6	DCC	Draxin	13176(Tax:10090)	70433(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Draxin inhibits axonal outgrowth through the netrin receptor DCC .
25249451	0	DCC	15,18	GSTT1	26,31	DCC	GSTT1	1630	2952	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association of DCC , MLH1 , GSTT1 , GSTM1 , and TP53 gene polymorphisms with colorectal_cancer in Kazakhstan .
25249451	0	DCC	15,18	MLH1	20,24	DCC	MLH1	1630	4292	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association of DCC , MLH1 , GSTT1 , GSTM1 , and TP53 gene polymorphisms with colorectal_cancer in Kazakhstan .
12799072	0	DCC	45,48	Netrin-1	14,22	DCC	Netrin-1	13176(Tax:10090)	18208(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung .
15557120	0	DCC	19,22	Netrin-1	39,47	DCC	Netrin-1	378529(Tax:8355)	373694(Tax:8355)	Gene	Gene	Phosphorylation|nmod|START_ENTITY mediates|nsubj|Phosphorylation mediates|dobj|END_ENTITY	Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance .
19409494	0	DCC	48,51	Netrin-1	22,30	DCC	Netrin-1	13176(Tax:10090)	18208(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration .
25950802	0	DCC	11,14	Netrin-1	0,8	DCC	Netrin-1	1630	9423	Gene	Gene	Systems|compound|START_ENTITY END_ENTITY|dep|Systems	Netrin-1 - DCC Signaling Systems and Age-Related Macular_Degeneration .
9950216	0	DCC	57,60	Netrin-1	0,8	DCC	Netrin-1	1630	9423	Gene	Gene	deleted_in_colorectal_cancer|appos|START_ENTITY interaction|nmod|deleted_in_colorectal_cancer END_ENTITY|dep|interaction	Netrin-1 : interaction with deleted_in_colorectal_cancer -LRB- DCC -RRB- and alterations in brain_tumors and neuroblastomas .
24400119	0	DCC	69,72	deleted_in_colorectal_cancer	39,67	DCC	deleted in colorectal cancer	13176(Tax:10090)	13176(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Defining the ligand specificity of the deleted_in_colorectal_cancer -LRB- DCC -RRB- receptor .
7553661	0	DCC	34,37	deleted_in_colorectal_cancer	4,32	DCC	deleted in colorectal cancer	1630	1630	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The deleted_in_colorectal_cancer -LRB- DCC -RRB- gene : a candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules .
7813784	0	DCC	63,66	deleted_in_colorectal_cancer	33,61	DCC	deleted in colorectal cancer	378529(Tax:8355)	378529(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of a homologue of the deleted_in_colorectal_cancer -LRB- DCC -RRB- gene in the nervous system of developing Xenopus embryos .
8044801	0	DCC	73,76	deleted_in_colorectal_cancer	43,71	DCC	deleted in colorectal cancer	1630	1630	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression and alternative splicing of the deleted_in_colorectal_cancer -LRB- DCC -RRB- gene in normal and malignant tissues .
11170725	0	DCC	41,44	netrin-1	14,22	DCC	netrin-1	25311(Tax:10116)	114523(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of netrin-1 and its receptors DCC and UNC-5H2 after axotomy and during regeneration of adult rat retinal ganglion cells .
11239160	0	DCC	11,14	netrin-1	18,26	DCC	netrin-1	25311(Tax:10116)	114523(Tax:10116)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|activation activation|amod|END_ENTITY	Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation .
11927147	0	DCC	46,49	netrin-1	14,22	DCC	netrin-1	25311(Tax:10116)	114523(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Expression of netrin-1 and netrin-1 receptor , DCC , in the rat olfactory nerve pathway during development and axonal regeneration .
15730872	0	DCC	67,70	netrin-1	110,118	DCC	netrin-1	1630	9423	Gene	Gene	deleted_in_colorectal_cancer|appos|START_ENTITY immunoreactivity|nmod|deleted_in_colorectal_cancer Localization|nmod|immunoreactivity Localization|amod|END_ENTITY	Localization of immunoreactivity for deleted_in_colorectal_cancer -LRB- DCC -RRB- , the receptor for the guidance factor netrin-1 , in ventral tier dopamine projection pathways in adult rodents .
16337279	0	DCC	145,148	netrin-1	136,144	DCC	netrin-1	25311(Tax:10116)	114523(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis : possible role of the netrin-1 / DCC binding pathway in an autoimmune_PNS_disorder .
16337279	0	DCC	145,148	netrin-1	23,31	DCC	netrin-1	25311(Tax:10116)	114523(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY role|nmod|pathway expression|dep|role expression|nmod|protein protein|amod|END_ENTITY	Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis : possible role of the netrin-1 / DCC binding pathway in an autoimmune_PNS_disorder .
17334389	0	DCC	55,58	netrin-1	18,26	DCC	netrin-1	1630	9423	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion , tumor growth and metastasis .
17574219	0	DCC	41,44	netrin-1	14,22	DCC	netrin-1	25311(Tax:10116)	114523(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of netrin-1 and its receptors DCC and neogenin in rat brain after ischemia .
18585357	0	DCC	50,53	netrin-1	88,96	DCC	netrin-1	378529(Tax:8355)	373694(Tax:8355)	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|advcl|mediating mediating|advcl|turning turning|nmod|END_ENTITY	DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1 .
23641072	0	DCC	29,32	netrin-1	41,49	DCC	netrin-1	1630	9423	Gene	Gene	TUBB3|nmod|START_ENTITY binding|nmod|TUBB3 couples|nsubj|binding couples|xcomp|END_ENTITY	Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance .
25123307	0	DCC	50,53	netrin-1	25,33	DCC	netrin-1	1630	9423	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue .
25123307	0	DCC	50,53	netrin-1	85,93	DCC	netrin-1	1630	9423	Gene	Gene	complex|nmod|START_ENTITY netrin-1|nmod|complex structure|nmod|netrin-1 reveals|nsubj|structure reveals|dobj|bifunctionality bifunctionality|nmod|cue cue|amod|END_ENTITY	The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue .
25881791	0	DCC	45,48	netrin-1	27,35	DCC	netrin-1	1630	9423	Gene	Gene	START_ENTITY|nsubj|mechanism mechanism|nmod|receptor receptor|amod|END_ENTITY	Signaling mechanism of the netrin-1 receptor DCC in axon guidance .
26882243	0	DCC	19,22	netrin-1	10,18	DCC	netrin-1	1630	9423	Gene	Gene	START_ENTITY|dep|Targeting Targeting|xcomp|END_ENTITY	Targeting netrin-1 / DCC interaction in diffuse large B-cell and mantle_cell_lymphomas .
9427245	0	DCC	87,90	netrin-1	37,45	DCC	netrin-1	378529(Tax:8355)	373694(Tax:8355)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Turning Turning|nmod|cones cones|nmod|gradient gradient|amod|END_ENTITY	Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC .
23746548	0	DCDC2	46,51	ETV6	25,29	DCDC2	ETV6	51473	2120	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language_impairment .
21085612	0	DCIR	14,18	CD4	33,36	DCIR	CD4	50856	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	HIV-1 induces DCIR expression in CD4 + T cells .
26514427	0	DCIR	0,4	IL-1b	42,47	DCIR	IL-1b	50856	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	DCIR negatively regulates CpG-ODN-induced IL-1b and IL-6 production .
18632569	0	DCL1	90,94	HYL1	25,29	DCL1	HYL1	839574(Tax:3702)	837498(Tax:3702)	Gene	Gene	promote|nmod|START_ENTITY promote|nsubj|END_ENTITY	The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1 .
16810317	0	DCL2	41,45	DCL4	84,88	DCL2	DCL4	821300(Tax:3702)	832154(Tax:3702)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAs .
16810317	0	DCL4	84,88	DCL2	41,45	DCL4	DCL2	832154(Tax:3702)	821300(Tax:3702)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	An antagonistic function for Arabidopsis DCL2 in development and a new function for DCL4 in generating viral siRNAs .
26366338	0	DCLK1	69,74	LGR5	82,86	DCLK1	LGR5	9201	8549	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1 , MSI1 , LGR5 , and BMI1 .
26366338	0	DCLK1	69,74	MSI1	76,80	DCLK1	MSI1	9201	4440	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1 , MSI1 , LGR5 , and BMI1 .
15988528	0	DCN-1	22,27	Dcn1p	28,33	DCN-1	Dcn1p	175556(Tax:6239)	175556(Tax:6239)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	The conserved protein DCN-1 / Dcn1p is required for cullin neddylation in C. _ elegans and S. _ cerevisiae .
17923697	0	DCP1	46,50	EDC3	23,27	DCP1	EDC3	196513	80153	Gene	Gene	binding|compound|START_ENTITY binding|compound|END_ENTITY	A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting .
21859862	0	DCP1a	39,44	c-Jun_N-terminal_kinase	0,23	DCP1a	c-Jun N-terminal kinase	55802	5599	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Jun_N-terminal_kinase phosphorylates DCP1a to control formation of P bodies .
15326253	0	DCTN1	49,54	dynactin	39,47	DCTN1	dynactin	1639	1639	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Point mutations of the p150 subunit of dynactin -LRB- DCTN1 -RRB- gene in ALS .
17824900	0	DCTN1	30,35	dynactin	20,28	DCTN1	dynactin	1639	1639	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The p150 subunit of dynactin -LRB- DCTN1 -RRB- gene in multiple_sclerosis .
16530423	0	DCX	49,52	doublecortin	35,47	DCX	doublecortin	1641	1641	Gene	Gene	dephosphorylation|appos|START_ENTITY dephosphorylation|nmod|END_ENTITY	Site-specific dephosphorylation of doublecortin -LRB- DCX -RRB- by protein_phosphatase_1 -LRB- PP1 -RRB- .
16814268	0	DCX	48,51	doublecortin	34,46	DCX	doublecortin	752002(Tax:59729)	752002(Tax:59729)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The distribution of expression of doublecortin -LRB- DCX -RRB- mRNA and protein in the zebra_finch brain .
16530423	0	DCX	49,52	protein_phosphatase_1	57,78	DCX	protein phosphatase 1	1641	5464	Gene	Gene	dephosphorylation|appos|START_ENTITY dephosphorylation|nmod|END_ENTITY	Site-specific dephosphorylation of doublecortin -LRB- DCX -RRB- by protein_phosphatase_1 -LRB- PP1 -RRB- .
19489685	0	DD3	25,28	PCA3	29,33	DD3	PCA3	50652	50652	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	The combination of urine DD3 -LRB- PCA3 -RRB- mRNA and PSA mRNA as molecular markers of prostate_cancer .
26820536	0	DDA3	23,27	ANKRD53	0,7	DDA3	ANKRD53	84722	79998	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis .
18793611	0	DDA3	11,15	ASPP2	22,27	DDA3	ASPP2	84722	7159	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
18793611	0	DDA3	11,15	BAX	73,76	DDA3	BAX	84722	581	Gene	Gene	binds|compound|START_ENTITY ASPP2|nsubj|binds ASPP2|nmod|activation activation|compound|END_ENTITY	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
25998387	0	DDA3	0,4	Cep290	13,19	DDA3	Cep290	84722	80184	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	DDA3 targets Cep290 into the centrosome to regulate spindle positioning .
18411309	0	DDA3	0,4	Kif2a	39,44	DDA3	Kif2a	84722	3796	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement .
26797278	0	DDA3	21,25	Ska1	0,4	DDA3	Ska1	84722	220134	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Ska1 cooperates with DDA3 for spindle dynamics and spindle attachment to kinetochore .
17296339	0	DDAH	99,103	dimethylarginine_dimethylaminohydrolase	58,97	DDAH	dimethylarginine dimethylaminohydrolase	51793(Tax:10090)	51793(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	A stable-isotope based technique for the determination of dimethylarginine_dimethylaminohydrolase -LRB- DDAH -RRB- activity in mouse tissue .
23097221	0	DDAH	53,57	dimethylarginine_dimethylaminohydrolase	12,51	DDAH	dimethylarginine dimethylaminohydrolase	23576	23576	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of dimethylarginine_dimethylaminohydrolase -LRB- DDAH -RRB- in pulmonary_fibrosis .
19757398	0	DDAH1	54,59	Dimethylarginine_Dimethylaminohydrolase_1	11,52	DDAH1	Dimethylarginine Dimethylaminohydrolase 1	23576	23576	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for Dimethylarginine_Dimethylaminohydrolase_1 -LRB- DDAH1 -RRB- in mammalian development .
23892448	0	DDAH1	73,78	dimethylarginine_dimethylaminohydrolase_1	25,66	DDAH1	dimethylarginine dimethylaminohydrolase 1	23576	23576	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the dimethylarginine_dimethylaminohydrolase_1 gene -LRB- DDAH1 -RRB- is related to asymmetric dimethylarginine -LRB- ADMA -RRB- levels , but not to endothelium-dependent vasodilation .
24895913	0	DDAH1	7,12	miR-21	0,6	DDAH1	miR-21	23576	406991	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	miR-21 / DDAH1 pathway regulates pulmonary vascular responses to hypoxia .
23770786	0	DDAH2	60,65	dimethylarginine-dimethylaminohydrolase-II	16,58	DDAH2	dimethylarginine-dimethylaminohydrolase-II	23564	23564	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Distribution of dimethylarginine-dimethylaminohydrolase-II -LRB- DDAH2 -RRB- gene polymorphism in hemodialysis patients .
17977009	0	DDAH2	124,129	dimethylarginine_dimethylaminohydrolase_2	81,122	DDAH2	dimethylarginine dimethylaminohydrolase 2	23564	23564	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nebivolol reduces asymmetric_dimethylarginine in endothelial cells by increasing dimethylarginine_dimethylaminohydrolase_2 -LRB- DDAH2 -RRB- expression and activity .
17145765	0	DDB-1	103,108	CUL-4	97,102	DDB-1	CUL-4	178156(Tax:6239)	174198(Tax:6239)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The Caenorhabditis_elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4 / DDB-1 complex .
19276361	0	DDB1	0,4	Chk1	13,17	DDB1	Chk1	1642	1111	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress .
25970626	0	DDB1	76,80	Cullin_4B	66,75	DDB1	Cullin 4B	1642	8450	Gene	Gene	Complex|compound|START_ENTITY Complex|compound|END_ENTITY	FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin_4B / DDB1 Complex .
22927934	0	DDB1	51,55	UV-damaged_DNA_binding_protein_1	17,49	DDB1	UV-damaged DNA binding protein 1	778355(Tax:4081)	778355(Tax:4081)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role of tomato UV-damaged_DNA_binding_protein_1 -LRB- DDB1 -RRB- in organ size control via an epigenetic manner .
12181326	0	DDB1	124,128	damaged_DNA_binding_1	101,122	DDB1	damaged DNA binding 1	1642	1642	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a Schizosaccharomyces_pombe_strain deleted for a sequence homologue of the human damaged_DNA_binding_1 -LRB- DDB1 -RRB- gene .
24157211	0	DDB1A	56,61	UVH6	50,54	DDB1A	UVH6	825890(Tax:3702)	839557(Tax:3702)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Interactions between Arabidopsis DNA repair genes UVH6 , DDB1A , and DDB2 during abiotic stress tolerance and floral development .
24200966	0	DDB2	0,4	PCNA	22,26	DDB2	PCNA	1643	5111	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	DDB2 association with PCNA is required for its degradation after UV-induced DNA damage .
23159851	0	DDB2	50,54	USP24	29,34	DDB2	USP24	1643	23358	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability .
11564859	0	DDB2	47,51	cullin_4A	76,85	DDB2	cullin 4A	1643	8451	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin_4A in mammalian cells .
26879405	0	DDB2	0,4	damaged-DNA_binding_2	6,27	DDB2	damaged-DNA binding 2	1643	1643	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	DDB2 -LRB- damaged-DNA_binding_2 -RRB- protein : a new modulator of nanomechanical properties and cell adhesion of breast_cancer cells .
15700318	0	DDB2	42,46	p38	25,28	DDB2	p38	1643	1432	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Potential attenuation of p38 signaling by DDB2 as a factor in acquired TNF resistance .
18806262	0	DDB2	90,94	p38	4,7	DDB2	p38	1643	1432	Gene	Gene	degradation|compound|START_ENTITY augments|nmod|degradation augments|nsubj|kinase kinase|amod|END_ENTITY	The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation .
26924680	0	DDC	44,47	DOPA_Decarboxylase	24,42	DDC	DOPA Decarboxylase	1644	1644	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Common Variation in the DOPA_Decarboxylase -LRB- DDC -RRB- Gene and Human Striatal DDC Activity In Vivo .
15879433	0	DDC	76,79	DOPA_decarboxylase	56,74	DDC	DOPA decarboxylase	1644	1644	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Haplotype analysis indicates an association between the DOPA_decarboxylase -LRB- DDC -RRB- gene and nicotine_dependence .
18586020	0	DDC	66,69	L-Dopa_decarboxylase	44,64	DDC	L-Dopa decarboxylase	1644	1644	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis and clinical utility of L-Dopa_decarboxylase -LRB- DDC -RRB- in prostate_cancer .
16740595	0	DDC	45,48	dopa_decarboxylase	25,43	DDC	dopa decarboxylase	1644	1644	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Intronic variants in the dopa_decarboxylase -LRB- DDC -RRB- gene are associated with smoking behavior in European-Americans and African-Americans .
12805099	0	DDP1	101,105	deafness-dystonia_peptide	74,99	DDP1	deafness-dystonia peptide	1678	1678	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical and molecular findings in a patient with a novel mutation in the deafness-dystonia_peptide -LRB- DDP1 -RRB- gene .
11489896	0	DDP1	41,45	deafness_dystonia_peptide_1	12,39	DDP1	deafness dystonia peptide 1	1678	1678	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the deafness_dystonia_peptide_1 -LRB- DDP1 -RRB- in import of human Tim23 into the inner membrane of mitochondria .
17101694	0	DDR1	79,83	CCN3	0,4	DDR1	CCN3	780	4856	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1 .
12628922	0	DDR1	32,36	p53	0,3	DDR1	p53	780	7157	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop .
23822953	0	DDR2	102,106	SHP-2	56,61	DDR2	SHP-2	4921	5781	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Phosphoproteomics of collagen_receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung_cancer mutants .
20734453	0	DDR2	50,54	discoidin_domain_receptor_2	21,48	DDR2	discoidin domain receptor 2	4921	4921	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	An essential role of discoidin_domain_receptor_2 -LRB- DDR2 -RRB- in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation .
24885564	0	DDR2	77,81	discoidin_domain_receptor_2	48,75	DDR2	discoidin domain receptor 2	4921	4921	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of novel driver mutations of the discoidin_domain_receptor_2 -LRB- DDR2 -RRB- gene in squamous_cell_lung_cancer of Chinese patients .
25355563	0	DDR2	57,61	discoidin_domain_receptor_2	28,55	DDR2	discoidin domain receptor 2	4921	4921	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The anti-angiogenic role of discoidin_domain_receptor_2 -LRB- DDR2 -RRB- in laser-induced choroidal_neovascularization .
18729217	0	DDX-23	27,33	PRP28	70,75	DDX-23	PRP28	175818(Tax:6239)	851830(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	The Caenorhabditis_elegans DDX-23 , a homolog of yeast splicing factor PRP28 , is required for the sperm-oocyte switch and differentiation of various cell types .
21761397	0	DDX1	12,16	DEAD_box_1	0,10	DDX1	DEAD box 1	1653	1653	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	DEAD_box_1 -LRB- DDX1 -RRB- expression predicts for local control and overall survival in early stage , node-negative breast_cancer .
24023901	0	DDX1	17,21	KSRP	60,64	DDX1	KSRP	1653	8570	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	DEAD box protein DDX1 regulates cytoplasmic localization of KSRP .
19058135	0	DDX1	26,30	RelA	46,50	DDX1	RelA	1653	5970	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription .
25260534	0	DDX21	9,14	c-Jun	25,30	DDX21	c-Jun	9188	3725	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast_cancers .
11593297	0	DDX26	30,35	DEAD-box_RNA_helicase	45,66	DDX26	DEAD-box RNA helicase	54606	54606	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization of DDX26 , a human DEAD-box_RNA_helicase , located on chromosome 7p12 .
22034099	0	DDX3	26,30	DDX5	46,50	DDX3	DDX5	1654	1655	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The DEAD-box RNA helicase DDX3 interacts with DDX5 , co-localizes with it in the cytoplasm during the G2/M phase of the cycle , and affects its shuttling during mRNP export .
26149384	0	DDX3	37,41	Ezrin	0,5	DDX3	Ezrin	1654	7430	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Ezrin binds to DEAD-box RNA helicase DDX3 and regulates its function and protein level .
26454002	0	DDX3	0,4	PACT	77,81	DDX3	PACT	1654	8575	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	DDX3 functions in antiviral innate immunity through translational control of PACT .
21237216	0	DDX3	12,16	Snail	31,36	DDX3	Snail	1654	6615	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of DDX3 in regulating Snail .
23413191	0	DDX3	13,17	casein_kinase_1	45,60	DDX3	casein kinase 1	1654	122011	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	RNA helicase DDX3 is a regulatory subunit of casein_kinase_1 in Wnt-b-catenin signaling .
18628297	0	DDX3	6,10	eIF3	89,93	DDX3	eIF3	1654	8661	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Human DDX3 functions in translation and interacts with the translation initiation factor eIF3 .
22872150	0	DDX3	17,21	eIF4F	38,43	DDX3	eIF4F	1654	1981	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs .
25208899	0	DDX3X	0,5	DDX3Y	36,41	DDX3X	DDX3Y	1654	8653	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	DDX3X , the X homologue of AZFa gene DDX3Y , expresses a complex pattern of transcript variants only in the male germ line .
25208899	0	DDX3Y	36,41	DDX3X	0,5	DDX3Y	DDX3X	8653	1654	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	DDX3X , the X homologue of AZFa gene DDX3Y , expresses a complex pattern of transcript variants only in the male germ line .
22034099	0	DDX5	46,50	DDX3	26,30	DDX5	DDX3	1655	1654	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The DEAD-box RNA helicase DDX3 interacts with DDX5 , co-localizes with it in the cytoplasm during the G2/M phase of the cycle , and affects its shuttling during mRNP export .
23108395	0	DDX5	0,4	NOTCH1	42,48	DDX5	NOTCH1	1655	4851	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T_cell_acute_lymphoblastic_leukemia .
26212035	0	DDX5	0,4	b-catenin	96,105	DDX5	b-catenin	1655	1499	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	DDX5 promotes proliferation and tumorigenesis of non-small-cell_lung_cancer cells by activating b-catenin signaling pathway .
17392519	0	DDX6	52,56	Ataxin-2	0,8	DDX6	Ataxin-2	1656	6311	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules .
23932921	0	DDX6	0,4	miR-143	43,50	DDX6	miR-143	1656	406935	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	DDX6 post-transcriptionally down-regulates miR-143 / 145 expression through host gene NCR143/145 in cancer cells .
11593297	0	DEAD-box_RNA_helicase	45,66	DDX26	30,35	DEAD-box RNA helicase	DDX26	54606	54606	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of DDX26 , a human DEAD-box_RNA_helicase , located on chromosome 7p12 .
21761397	0	DEAD_box_1	0,10	DDX1	12,16	DEAD box 1	DDX1	1653	1653	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	DEAD_box_1 -LRB- DDX1 -RRB- expression predicts for local control and overall survival in early stage , node-negative breast_cancer .
22723967	0	DEAF1	16,21	LMO4	92,96	DEAF1	LMO4	10522	8543	Gene	Gene	domains|nummod|START_ENTITY Contribution|nmod|domains Contribution|nmod|END_ENTITY	Contribution of DEAF1 structural domains to the interaction with the breast_cancer oncogene LMO4 .
25310299	0	DEAF1	94,99	LMO4	145,149	DEAF1	LMO4	10522	8543	Gene	Gene	Protein|appos|START_ENTITY Structure|nmod|Protein Reveals|nsubj|Structure Reveals|nmod|END_ENTITY	The Structure of an LIM-Only Protein 4 -LRB- LMO4 -RRB- and Deformed_Epidermal_Autoregulatory_Factor-1 -LRB- DEAF1 -RRB- Complex Reveals a Common Mode of Binding to LMO4 .
25310299	0	DEAF1	94,99	LMO4	40,44	DEAF1	LMO4	10522	8543	Gene	Gene	Protein|appos|START_ENTITY Protein|appos|END_ENTITY	The Structure of an LIM-Only Protein 4 -LRB- LMO4 -RRB- and Deformed_Epidermal_Autoregulatory_Factor-1 -LRB- DEAF1 -RRB- Complex Reveals a Common Mode of Binding to LMO4 .
18650418	0	DEC-205	61,68	Pla	22,25	DEC-205	Pla	17076(Tax:10090)	13917718	Gene	Gene	utilizes|dobj|START_ENTITY utilizes|nsubj|END_ENTITY	Plasminogen activator Pla of Yersinia_pestis utilizes murine DEC-205 -LRB- CD205 -RRB- as a receptor to promote dissemination .
12624110	0	DEC1	0,4	DEC2	44,48	DEC1	DEC2	50514	79365	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter .
15066123	0	DEC1	23,27	DEC2	60,64	DEC1	DEC2	50514	79365	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|suppressor suppressor|nsubj|END_ENTITY	Rhythmic expression of DEC1 and DEC2 in peripheral tissues : DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP .
26498531	0	DEC1	0,4	LKB1	44,48	DEC1	LKB1	20893(Tax:10090)	20869(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	DEC1 negatively regulates AMPK activity via LKB1 .
11880636	0	DEC1	0,4	TGF-beta	31,39	DEC1	TGF-beta	50514	7040	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities .
21506129	0	DEC1	44,48	cyclin_D1	70,79	DEC1	cyclin D1	50514	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin_D1 .
22572381	0	DEC2	26,30	Bim	62,65	DEC2	Bim	79365	10018	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral_cancer HSC-3 cells .
12624110	0	DEC2	44,48	DEC1	0,4	DEC2	DEC1	79365	50514	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter .
15066123	0	DEC2	60,64	DEC1	23,27	DEC2	DEC1	79365	50514	Gene	Gene	suppressor|nsubj|START_ENTITY expression|parataxis|suppressor expression|nmod|END_ENTITY	Rhythmic expression of DEC1 and DEC2 in peripheral tissues : DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP .
15448136	0	DEC2	8,12	Sharp-1	0,7	DEC2	Sharp-1	79362(Tax:10090)	79362(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	Sharp-1 / DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors .
25446074	0	DEC2	55,59	Twist1	81,87	DEC2	Twist1	79362(Tax:10090)	22160(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The basic helix-loop-helix -LRB- bHLH -RRB- transcription factor DEC2 negatively regulates Twist1 through an E-box element .
18233956	0	DEC2	51,55	vascular_endothelial_growth_factor	77,111	DEC2	vascular endothelial growth factor	79362(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Basic-helix-loop-helix -LRB- bHLH -RRB- transcription factor DEC2 negatively regulates vascular_endothelial_growth_factor expression .
20553715	0	DEDD	0,4	transforming_growth_factor-beta1	26,58	DEDD	transforming growth factor-beta1	9191	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	DEDD negatively regulates transforming_growth_factor-beta1 signaling by interacting with Smad3 .
11773070	0	DEF-1	0,5	ARF1	53,57	DEF-1	ARF1	13196(Tax:10090)	11840(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	DEF-1 / ASAP1 is a GTPase-activating protein -LRB- GAP -RRB- for ARF1 that enhances cell motility through a GAP-dependent mechanism .
16984277	0	DEFB1	36,41	beta-defensin_1	14,29	DEFB1	beta-defensin 1	1672	1672	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SNPs in human beta-defensin_1 gene -LRB- DEFB1 -RRB- : frequencies in a Mexican population and new PCR-RFLPs assays .
20679419	0	DEG-3	36,41	DES-2	42,47	DEG-3	DES-2	3565200(Tax:6239)	179574(Tax:6239)	Gene	Gene	START_ENTITY|parataxis|Haemonchus_contortus Haemonchus_contortus|nsubj|channels channels|compound|END_ENTITY	Monepantel allosterically activates DEG-3 / DES-2 channels of the gastrointestinal_nematode Haemonchus_contortus .
22072793	0	DENND1C	13,20	Connecdenn_3	0,12	DENND1C	Connecdenn 3	79958	79958	Gene	Gene	binds|nsubj|START_ENTITY END_ENTITY|parataxis|binds	Connecdenn_3 / DENND1C binds actin linking Rab35 activation to the actin cytoskeleton .
25713415	0	DENND2B	0,7	Rab13	18,23	DENND2B	Rab13	6764	5872	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior .
25925668	0	DENND3	39,45	Rab12	89,94	DENND3	Rab12	22898	201475	Gene	Gene	Phosphorylation|nmod|START_ENTITY activates|nsubj|Phosphorylation activates|dobj|END_ENTITY	Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy .
11101902	0	DEP	55,58	dishevelled	43,54	DEP	dishevelled	68268(Tax:10090)	13542(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway .
19937567	0	DEPP	73,77	decidual_protein_induced_by_progesterone	31,71	DEPP	decidual protein induced by progesterone	213393(Tax:10090)	213393(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Insulin-mediated regulation of decidual_protein_induced_by_progesterone -LRB- DEPP -RRB- in adipose tissue and liver .
26558456	0	DEPTOR	71,77	Androgen_receptor	0,17	DEPTOR	Androgen receptor	64798	367	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Androgen_receptor functions as a negative transcriptional regulator of DEPTOR , mTOR inhibitor .
22017877	0	DEPTOR	101,107	bTrCP	60,65	DEPTOR	bTrCP	64798	8945	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	mTOR generates an auto-amplification loop by triggering the bTrCP - and CK1a-dependent degradation of DEPTOR .
19446321	0	DEPTOR	0,6	mTOR	13,17	DEPTOR	mTOR	64798	21977(Tax:10090)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival .
22017876	0	DEPTOR	0,6	mTOR	11,15	DEPTOR	mTOR	64798	21977(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	DEPTOR , an mTOR inhibitor , is a physiological substrate of SCF -LRB- bTrCP -RRB- E3 ubiquitin ligase and regulates survival and autophagy .
26558456	0	DEPTOR	71,77	mTOR	79,83	DEPTOR	mTOR	64798	21977(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Androgen_receptor functions as a negative transcriptional regulator of DEPTOR , mTOR inhibitor .
24969890	0	DEPTOR	0,6	mTORC1	45,51	DEPTOR	mTORC1	64798	382056(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|activity activity|amod|END_ENTITY	DEPTOR expression negatively correlates with mTORC1 activity and tumor progression in colorectal_cancer .
25936805	0	DEPTOR	52,58	mTORC1	34,40	DEPTOR	mTORC1	64798	382056(Tax:10090)	Gene	Gene	Inhibitor|appos|START_ENTITY Inhibitor|amod|END_ENTITY	Rapid Mitogenic Regulation of the mTORC1 Inhibitor , DEPTOR , by Phosphatidic_Acid .
11587224	0	DERL-2	42,48	CD56	50,54	DERL-2	CD56	51009	4684	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Characterization of two novel cell lines , DERL-2 -LRB- CD56 + / CD3 + / Tcry5 + -RRB- and DERL-7 -LRB- CD56 + / CD3 - / TCRgammadelta - -RRB- , derived from a single patient with CD56 + non-Hodgkin 's _ lymphoma .
20679419	0	DES-2	42,47	DEG-3	36,41	DES-2	DEG-3	179574(Tax:6239)	3565200(Tax:6239)	Gene	Gene	channels|compound|START_ENTITY Haemonchus_contortus|nsubj|channels END_ENTITY|parataxis|Haemonchus_contortus	Monepantel allosterically activates DEG-3 / DES-2 channels of the gastrointestinal_nematode Haemonchus_contortus .
21884973	0	DET1	27,31	CCA1	37,41	DET1	CCA1	826609(Tax:3702)	819296(Tax:3702)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock .
17452440	0	DET1	10,14	Cul4A	25,30	DET1	Cul4A	55070	8451	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes .
25505834	0	DFNA17	24,30	MYH9	9,13	DFNA17	MYH9	4627	4627	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	c.G2114A MYH9 mutation -LRB- DFNA17 -RRB- causes non-syndromic autosomal dominant hearing_loss in a Brazilian family .
24616153	0	DFNA48	69,75	MYO1A	57,62	DFNA48	MYO1A	4640	4640	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Targeted and genomewide NGS data disqualify mutations in MYO1A , the `` DFNA48 gene '' , as a cause of deafness .
24154762	0	DFNA5	33,38	DFNA5	73,78	DFNA5	DFNA5	1687	1687	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression and regulation of DFNA5 in human hepatocellular_carcinoma DFNA5 in hepatocellular_carcinoma .
24154762	0	DFNA5	73,78	DFNA5	33,38	DFNA5	DFNA5	1687	1687	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression and regulation of DFNA5 in human hepatocellular_carcinoma DFNA5 in hepatocellular_carcinoma .
12461698	0	DFNA5	3,8	age-related_hearing_impairment	35,65	DFNA5	age-related hearing impairment	1687	9077	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Is DFNA5 a susceptibility gene for age-related_hearing_impairment ?
10891988	0	DFNA9	78,83	COCH	63,67	DFNA9	COCH	1690	1690	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Familial progressive vestibulocochlear_dysfunction caused by a COCH mutation -LRB- DFNA9 -RRB- .
16151338	0	DFNA9	83,88	COCH	68,72	DFNA9	COCH	1690	1690	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Vestibular_deterioration precedes hearing_deterioration in the P51S COCH mutation -LRB- DFNA9 -RRB- : an analysis in 74 mutation carriers .
27023102	0	DFNA9	68,73	COCH	53,57	DFNA9	COCH	1690	1690	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	Histopathology of the Human Inner Ear in the p.L114P COCH Mutation -LRB- DFNA9 -RRB- .
25885414	0	DFNB49	10,16	MARVELD2	0,8	DFNB49	MARVELD2	153562	153562	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	MARVELD2 -LRB- DFNB49 -RRB- Mutations in the Hearing Impaired Central European_Roma Population - Prevalence , Clinical Impact and the Common Origin .
19646679	0	DFNB73	19,25	BSND	40,44	DFNB73	BSND	7809	7809	Gene	Gene	START_ENTITY|dep|mutations mutations|nmod|END_ENTITY	Molecular basis of DFNB73 : mutations of BSND can cause nonsyndromic_deafness or Bartter_syndrome .
25557914	0	DFNB84	71,77	PTPRQ	60,65	DFNB84	PTPRQ	374462	374462	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural_hearing_impairment .
14718498	0	DFR	74,77	dihydroflavonol-4-reductase	45,72	DFR	dihydroflavonol-4-reductase	543117(Tax:4565)	543117(Tax:4565)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Isolation and location of three homoeologous dihydroflavonol-4-reductase -LRB- DFR -RRB- genes of wheat and their tissue-dependent expression .
2827121	0	DFR1	89,93	dihydrofolate_reductase	59,82	DFR1	dihydrofolate reductase	854411(Tax:4932)	854411(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization of the Saccharomyces_cerevisiae dihydrofolate_reductase gene -LRB- DFR1 -RRB- .
2838386	0	DFR1	60,64	dihydrofolate_reductase	30,53	DFR1	dihydrofolate reductase	854411(Tax:4932)	854411(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping and sequencing of the dihydrofolate_reductase gene -LRB- DFR1 -RRB- of Saccharomyces_cerevisiae .
12086643	0	DFXR	30,34	fragile_X	11,20	DFXR	fragile X	37528(Tax:7227)	37528(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Drosophila fragile_X protein , DFXR , regulates neuronal morphology and function in the brain .
11171174	0	DGAT	59,63	diacylglycerol_acyltransferase	27,57	DGAT	diacylglycerol acyltransferase	8694	8694	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Differential expression of diacylglycerol_acyltransferase -LRB- DGAT -RRB- genes in olive tissues .
15200432	0	DGAT-1	69,75	Diacylglycerol_acyltransferase-1	35,67	DGAT-1	Diacylglycerol acyltransferase-1	84497(Tax:10116)	84497(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Up-regulation of hepatic Acyl_CoA : Diacylglycerol_acyltransferase-1 -LRB- DGAT-1 -RRB- expression in nephrotic_syndrome .
21515696	0	DGAT1	15,20	ABI4	0,4	DGAT1	ABI4	816464(Tax:3702)	818614(Tax:3702)	Gene	Gene	expression|nummod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	ABI4 activates DGAT1 expression in Arabidopsis seedlings during nitrogen deficiency .
23919406	0	DGAT1	86,91	diacylglycerol_O-acyltransferase_1	50,84	DGAT1	diacylglycerol O-acyltransferase 1	8694	8694	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Current status of the research and development of diacylglycerol_O-acyltransferase_1 -LRB- DGAT1 -RRB- inhibitors .
18631243	0	DGAT1	88,93	diacylglycerol_acyltransferase_1	54,86	DGAT1	diacylglycerol acyltransferase 1	816464(Tax:3702)	816464(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of an acyl-CoA-dependent diacylglycerol_acyltransferase_1 -LRB- DGAT1 -RRB- gene from Tropaeolum majus , and a study of the functional motifs of the DGAT protein using site-directed mutagenesis to modify enzyme activity and oil content .
23735282	0	DGAT1	86,91	diacylglycerol_acyltransferase_1	52,84	DGAT1	diacylglycerol acyltransferase 1	13350(Tax:10090)	13350(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Evaluation of thiazole containing biaryl analogs as diacylglycerol_acyltransferase_1 -LRB- DGAT1 -RRB- inhibitors .
26804232	0	DGAT1	68,73	diacylglycerol_acyltransferase_1	34,66	DGAT1	diacylglycerol acyltransferase 1	8694	8694	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of diamide compounds as diacylglycerol_acyltransferase_1 -LRB- DGAT1 -RRB- inhibitors .
26898284	0	DGAT1	51,56	diacylglycerol_o-acyltransferase_1	15,49	DGAT1	diacylglycerol o-acyltransferase 1	282609(Tax:9913)	282609(Tax:9913)	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Effects of the diacylglycerol_o-acyltransferase_1 -LRB- DGAT1 -RRB- K232A polymorphism on fatty_acid , protein , and mineral composition of dairy cattle milk .
17477860	0	DGAT2	96,101	diacylglycerol_O-acyltransferase_homolog_2	47,89	DGAT2	diacylglycerol O-acyltransferase homolog 2	84649	84649	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation screen and association studies in the diacylglycerol_O-acyltransferase_homolog_2 gene -LRB- DGAT2 -RRB- , a positional candidate gene for early onset obesity on chromosome 11q13 .
15671038	0	DGAT2	122,127	diacylglycerol_acyltransferase_2	88,120	DGAT2	diacylglycerol acyltransferase 2	158833	158833	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of two novel human acyl-CoA wax alcohol acyltransferases : members of the diacylglycerol_acyltransferase_2 -LRB- DGAT2 -RRB- gene superfamily .
15821931	0	DGCR6	88,93	DiGeorge_critical_region_6	60,86	DGCR6	DiGeorge critical region 6	8214	8214	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Biochemical characterisation of the proteins encoded by the DiGeorge_critical_region_6 -LRB- DGCR6 -RRB- genes .
19778628	0	DGCR6L	0,6	PAK4	16,20	DGCR6L	PAK4	85359	10298	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	DGCR6L , a novel PAK4 interaction protein , regulates PAK4-mediated migration of human gastric_cancer cell via LIMK1 .
26126715	0	DGCR8	57,62	ABL	11,14	DGCR8	ABL	54487	25	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage .
11719522	0	DGKbeta	80,87	diacylglycerol_kinase_beta	52,78	DGKbeta	diacylglycerol kinase beta	1607	1607	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and characterization of the human diacylglycerol_kinase_beta -LRB- DGKbeta -RRB- gene : alternative splicing generates DGKbeta isotypes with different properties .
16611689	0	DGN-1	24,29	dystroglycan	11,23	DGN-1	dystroglycan	181283(Tax:6239)	181283(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY functions|amod|END_ENTITY	C. _ elegans dystroglycan DGN-1 functions in epithelia and neurons , but not muscle , and independently of dystrophin .
18194465	0	DHCR24	10,16	Seladin-1	0,9	DHCR24	Seladin-1	1718	1718	Gene	Gene	protects|nsubj|START_ENTITY END_ENTITY|parataxis|protects	Seladin-1 / DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content .
26628388	0	DHCR24	10,16	Seladin-1	0,9	DHCR24	Seladin-1	74754(Tax:10090)	74754(Tax:10090)	Gene	Gene	Neuroprotective|nsubj|START_ENTITY END_ENTITY|parataxis|Neuroprotective	Seladin-1 / DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke .
16407971	0	DHCR24	22,28	seladin-1	12,21	DHCR24	seladin-1	74754(Tax:10090)	74754(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of seladin-1 / DHCR24 in cholesterol biosynthesis , APP processing and Abeta generation in vivo .
18762779	0	DHCR24	46,52	seladin-1	36,45	DHCR24	seladin-1	1718	1718	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Androgen_receptor regulation of the seladin-1 / DHCR24 gene : altered expression in prostate_cancer .
12270273	0	DHCR7	58,63	delta7-sterol_reductase	33,56	DHCR7	delta7-sterol reductase	1717	1717	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two novel mutations of the human delta7-sterol_reductase -LRB- DHCR7 -RRB- gene in children with Smith-Lemli-Opitz_syndrome .
19338756	0	DHDPS	72,77	dihydrodipicolinate_synthase	42,70	DHDPS	dihydrodipicolinate synthase	8319276(Tax:562)	8319276(Tax:562)	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The C-terminal domain of Escherichia_coli dihydrodipicolinate_synthase -LRB- DHDPS -RRB- is essential for maintenance of quaternary structure and efficient catalysis .
12044959	0	DHEA-S	34,40	DHEA-S	64,70	DHEA-S	DHEA-S	6822	6822	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of anti-aging DHEA-S and the replacement of DHEA-S .
12044959	0	DHEA-S	64,70	DHEA-S	34,40	DHEA-S	DHEA-S	6822	6822	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of anti-aging DHEA-S and the replacement of DHEA-S .
15195991	0	DHEA-S	89,95	IGF-I	46,51	DHEA-S	IGF-I	6822	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Serum levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- , and their relationships with serum interleukin-6 , in the geriatric syndrome of frailty .
9218249	0	DHEAS	0,5	TNF	15,18	DHEAS	TNF	6822	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	DHEAS inhibits TNF production in monocytes , astrocytes and microglial cells .
18385200	0	DHFR	99,103	C-MYC	64,69	DHFR	C-MYC	1719	4609	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Clinical impact of the methotrexate resistance-associated genes C-MYC and dihydrofolate_reductase -LRB- DHFR -RRB- in high-grade osteosarcoma .
17019704	0	DHFR	80,84	NADPH	100,105	DHFR	NADPH	13361(Tax:10090)	67460(Tax:10090)	Gene	Gene	complexes|compound|START_ENTITY complexes|nmod|END_ENTITY	New insights into DHFR interactions : analysis of Pneumocystis_carinii and mouse DHFR complexes with NADPH and two highly potent 5 - -LRB- omega-carboxy -LRB- alkyloxy -RRB- trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions .
21206056	0	DHFR	54,58	NADPH	74,79	DHFR	NADPH	1719	1666	Gene	Gene	complexes|compound|START_ENTITY complexes|nmod|END_ENTITY	Structural analysis of Pneumocystis_carinii and human DHFR complexes with NADPH and a series of five potent 6 - -LSB- 5 ' - -LRB- __ - carboxyalkoxy -RRB- benzyl -RSB- pyrido -LSB- 2,3-d -RSB- pyrimidine derivatives .
23053953	0	DHFR	86,90	UDP-glucuronosyltransferase_2B17	14,46	DHFR	UDP-glucuronosyltransferase 2B17	1719	7367	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Evaluation of UDP-glucuronosyltransferase_2B17 -LRB- UGT2B17 -RRB- and dihydrofolate_reductase -LRB- DHFR -RRB- genes deletion and the expression level of NGX6 mRNA in breast_cancer .
11877086	0	DHFR	95,99	dihydrofolate_reductase	65,88	DHFR	dihydrofolate reductase	1719	1719	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- In vitro cotransfer human multidrug resistance gene -LRB- mdr-1 -RRB- and dihydrofolate_reductase gene -LRB- DHFR -RRB- into human CD -LRB- 34 -RRB- -LRB- + -RRB- progenitor cells to broaden the spectrum of drug resistance -RSB- .
12653939	0	DHFR	65,69	dihydrofolate_reductase	40,63	DHFR	dihydrofolate reductase	42003(Tax:7227)	42003(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning and expression of the dihydrofolate_reductase -LRB- DHFR -RRB- gene from adult buffalo fly -LRB- Haematobia irritans exigua -RRB- : effects of antifolates .
17336564	0	DHFR	53,57	dihydrofolate_reductase	28,51	DHFR	dihydrofolate reductase	1719	1719	Gene	Gene	Variation|appos|START_ENTITY Variation|nmod|END_ENTITY	Variation and expression of dihydrofolate_reductase -LRB- DHFR -RRB- in relation to spina_bifida .
18247058	0	DHFR	67,71	dihydrofolate_reductase	42,65	DHFR	dihydrofolate reductase	1719	1719	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An insertion/deletion polymorphism of the dihydrofolate_reductase -LRB- DHFR -RRB- gene is associated with serum and red blood cell folate concentrations in women .
21120433	0	DHFR	67,71	dihydrofolate_reductase	42,65	DHFR	dihydrofolate reductase	1719	1719	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	19-base pair deletion polymorphism of the dihydrofolate_reductase -LRB- DHFR -RRB- gene : maternal risk of Down syndrome and folate metabolism .
22324981	0	DHFR	40,44	dihydrofolate_reductase	15,38	DHFR	dihydrofolate reductase	1719	1719	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of dihydrofolate_reductase -LRB- DHFR -RRB- -317 AA genotype with poor response to methotrexate in patients with rheumatoid_arthritis .
8841631	0	DHFR	82,86	dihydrofolate_reductase	88,111	DHFR	dihydrofolate reductase	1719	1719	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel screening system for construction and selection of active ribozymes using DHFR -LRB- dihydrofolate_reductase -RRB- gene as selection marker .
3147883	0	DHFR	0,4	t-PA	24,28	DHFR	t-PA	508809(Tax:9913)	281407(Tax:9913)	Gene	Gene	coamplification|amod|START_ENTITY coamplification|nmod|END_ENTITY	DHFR coamplification of t-PA in DHFR + bovine endothelial cells : in vitro characterization of the purified serine protease .
3147883	0	DHFR	32,36	t-PA	24,28	DHFR	t-PA	508809(Tax:9913)	281407(Tax:9913)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	DHFR coamplification of t-PA in DHFR + bovine endothelial cells : in vitro characterization of the purified serine protease .
7855068	0	DHICA_oxidase	0,13	TRP1	26,30	DHICA oxidase	TRP1	22178(Tax:10090)	22178(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	DHICA_oxidase activity of TRP1 and interactions with other melanogenic enzymes .
22242798	0	DHODH	100,105	dihydroorotate_dehydrogenase	70,98	DHODH	dihydroorotate dehydrogenase	1723	1723	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	CoMFA and CoMSIA studies on aryl_carboxylic_acid_amide derivatives as dihydroorotate_dehydrogenase -LRB- DHODH -RRB- inhibitors .
22491477	0	DHPS	76,80	WDR83	33,38	DHPS	WDR83	1725	84292	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric_cancer .
19086271	0	DHR51	0,5	photoreceptor_cell-specific_nuclear_receptor	58,102	DHR51	photoreceptor cell-specific nuclear receptor	36702(Tax:7227)	10002	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	DHR51 , the Drosophila_melanogaster homologue of the human photoreceptor_cell-specific_nuclear_receptor , is a thiolate heme-binding protein .
26311046	0	DHRS7	29,34	SDR34C1	36,43	DHRS7	SDR34C1	51635	51635	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for the dehydrogenase DHRS7 -LRB- SDR34C1 -RRB- in prostate_cancer .
22569250	0	DHX15	69,74	RBM5	17,21	DHX15	RBM5	1665	10181	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity .
24651521	0	DHX36	0,5	RIG-I	15,20	DHX36	RIG-I	170506	23586	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation .
10675329	0	DIAP1	45,50	DRONC	23,28	DIAP1	DRONC	39753(Tax:7227)	39173(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The Drosophila caspase DRONC is regulated by DIAP1 .
12397080	0	DIAP1	15,20	DRONC	131,136	DIAP1	DRONC	39753(Tax:7227)	39173(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY required|nsubjpass|protein required|xcomp|prevent prevent|dobj|accumulation accumulation|nmod|form form|nmod|END_ENTITY	The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated , processed form of the apical caspase DRONC .
12021771	0	DIAP1	4,9	Dronc	49,54	DIAP1	Dronc	39753(Tax:7227)	39173(Tax:7227)	Gene	Gene	finger|compound|START_ENTITY mediates|nsubj|finger mediates|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis .
11550090	0	DIAP1	112,117	STRICA	0,6	DIAP1	STRICA	39753(Tax:7227)	35528(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	STRICA , a novel Drosophila_melanogaster caspase with an unusual serine/threonine-rich prodomain , interacts with DIAP1 and DIAP2 .
26147304	0	DICER1	58,64	DROSHA	50,56	DICER1	DROSHA	23405	29102	Gene	Gene	Associated|nsubj|START_ENTITY Associated|nmod|END_ENTITY	3 ' - UTR Polymorphisms in the MiRNA Machinery Genes DROSHA , DICER1 , RAN , and XPO5 Are Associated with Colorectal_Cancer Risk in a Korean Population .
24955153	0	DICER1	22,28	miR-18a	0,7	DICER1	miR-18a	23405	406953	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	miR-18a downregulates DICER1 and promotes proliferation and metastasis of nasopharyngeal_carcinoma .
16491118	0	DICKKOPF-1	46,56	DKK-1	58,63	DICKKOPF-1	DKK-1	22943	22943	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 -LRB- DKK-1 -RRB- gene in human colorectal_cancer .
21572098	0	DICKKOPF-3	67,77	miRNA-92	15,23	DICKKOPF-3	miRNA-92	27122	407047	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 -LRB- DKK3 -RRB- in neuroblastoma .
18039708	0	DIF2	93,97	tumor_necrosis_factor_alpha	48,75	DIF2	tumor necrosis factor alpha	8870	7124	Gene	Gene	promoter|compound|START_ENTITY signaling|nmod|promoter END_ENTITY|acl|signaling	Retinoic_acid modulates chromatin to potentiate tumor_necrosis_factor_alpha signaling on the DIF2 promoter .
19385039	0	DILP	111,115	Drosophila_insulin-producing_cells_increases_insulin-like_peptide	44,109	DILP	Drosophila insulin-producing cells increases insulin-like peptide	2768992(Tax:7227)	2768992(Tax:7227)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Expression of human uncoupling protein-3 in Drosophila_insulin-producing_cells_increases_insulin-like_peptide -LRB- DILP -RRB- levels and shortens lifespan .
18540090	0	DIN7	47,51	Dun1	28,32	DIN7	Dun1	851856(Tax:4932)	851457(Tax:4932)	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage .
15525349	0	DINE	53,57	damage-induced_neuronal_endopeptidase	14,51	DINE	damage-induced neuronal endopeptidase	60417(Tax:10116)	60417(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of damage-induced_neuronal_endopeptidase -LRB- DINE -RRB- mRNA in peri-infarct_cortical_and_thalamic_neurons following middle_cerebral_artery_occlusion .
15286152	0	DIO2	28,32	deiodinase_type_2	34,51	DIO2	deiodinase type 2	1734	1734	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Positive association of the DIO2 -LRB- deiodinase_type_2 -RRB- gene with mental_retardation in the iodine-deficient areas of China .
7504555	0	DIP	0,3	MIP	21,24	DIP	MIP	613430(Tax:9913)	280859(Tax:9913)	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	DIP : a member of the MIP family of membrane proteins that is expressed in mature seeds and dark-grown seedlings of Antirrhinum majus .
19947543	0	DIP1	90,94	CG32500	96,103	DIP1	CG32500	43981(Tax:7227)	2768879(Tax:7227)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Analysis of the structure and expression of the cluster of Drosophila_melanogaster genes DIP1 , CG32500 , CG32819 , and CG14476 in the flamenco gene region -RSB- .
19947543	0	DIP1	90,94	CG32819	105,112	DIP1	CG32819	43981(Tax:7227)	318227(Tax:7227)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Analysis of the structure and expression of the cluster of Drosophila_melanogaster genes DIP1 , CG32500 , CG32819 , and CG14476 in the flamenco gene region -RSB- .
24481677	0	DISC1	20,25	DBZ	0,3	DISC1	DBZ	244667(Tax:10090)	216049(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	DBZ , a CNS-specific DISC1 binding protein , positively regulates oligodendrocyte differentiation .
23347445	0	DISC1	69,74	Disrupted_in_Schizophrenia-1	39,67	DISC1	Disrupted in Schizophrenia-1	27185	27185	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effects of the adverse life events and Disrupted_in_Schizophrenia-1 -LRB- DISC1 -RRB- gene polymorphisms on acute symptoms of schizophrenia .
20624590	0	DISC1	34,39	Dixdc1	0,6	DISC1	Dixdc1	27185	85458	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Dixdc1 is a critical regulator of DISC1 and embryonic cortical development .
20643344	0	DISC1	10,15	Dixdc1	42,48	DISC1	Dixdc1	27185	85458	Gene	Gene	function|nsubj|START_ENTITY function|parataxis|selects selects|nsubj|END_ENTITY	Switching DISC1 function in neurogenesis : Dixdc1 selects DISC1 binding partners .
20643344	0	DISC1	57,62	Dixdc1	42,48	DISC1	Dixdc1	27185	85458	Gene	Gene	partners|nummod|START_ENTITY selects|dobj|partners selects|nsubj|END_ENTITY	Switching DISC1 function in neurogenesis : Dixdc1 selects DISC1 binding partners .
17202467	0	DISC1	0,5	Grb2	74,78	DISC1	Grb2	307940(Tax:10116)	81504(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2 .
23233134	0	DISC1	15,20	Tensin2	44,51	DISC1	Tensin2	244667(Tax:10090)	209039(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of DISC1 with the PTB domain of Tensin2 .
26212236	0	DISC1	0,5	VGF	47,50	DISC1	VGF	244667(Tax:10090)	381677(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway .
16814263	0	DISC1	55,60	disrupted-in-schizophrenia	27,53	DISC1	disrupted-in-schizophrenia	27185	27185	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of disrupted-in-schizophrenia -LRB- DISC1 -RRB- in bipolar_disorder .
15381924	0	DISC1	44,49	disrupted_in_schizophrenia_1	14,42	DISC1	disrupted in schizophrenia 1	244667(Tax:10090)	244667(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of disrupted_in_schizophrenia_1 -LRB- DISC1 -RRB- protein in the adult and developing mouse brain indicates its role in neurodevelopment .
24301646	0	DISC1	38,43	disrupted_in_schizophrenia_1	8,36	DISC1	disrupted in schizophrenia 1	307940(Tax:10116)	307940(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of disrupted_in_schizophrenia_1 -LRB- DISC1 -RRB- in stress-induced prefrontal cognitive_dysfunction .
10786627	0	DISP	63,67	serine_protease	46,61	DISP	serine protease	30943(Tax:10090)	50908(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Characterisation Characterisation|nmod|END_ENTITY	Characterisation of a novel murine intestinal serine_protease , DISP .
19572978	0	DIXDC1	0,6	p21	15,18	DIXDC1	p21	85458	644914	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	DIXDC1 targets p21 and cyclin_D1 via PI3K pathway activation to promote colon_cancer cell proliferation .
21852238	0	DJ-1	9,13	BCL-XL	55,61	DJ-1	BCL-XL	11315	598	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL .
18042550	0	DJ-1	0,4	Bax	15,18	DJ-1	Bax	11315	581	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	DJ-1 decreases Bax expression through repressing p53 transcriptional activity .
22892098	0	DJ-1	13,17	Bcl-XL	77,83	DJ-1	Bcl-XL	11315	598	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|dissociating dissociating|nmod|END_ENTITY	L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL .
24348900	0	DJ-1	120,124	DJ-1	58,62	DJ-1	DJ-1	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	DJ-1	120,124	DJ-1	86,90	DJ-1	DJ-1	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	DJ-1	58,62	DJ-1	120,124	DJ-1	DJ-1	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	DJ-1	58,62	DJ-1	86,90	DJ-1	DJ-1	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	DJ-1	86,90	DJ-1	120,124	DJ-1	DJ-1	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	DJ-1	86,90	DJ-1	58,62	DJ-1	DJ-1	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
26048984	0	DJ-1	67,71	ERK	52,55	DJ-1	ERK	11315	5594	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Epidermal_growth_factor-dependent activation of the ERK pathway by DJ-1 through its direct binding to c-Raf .
22871147	0	DJ-1	0,4	Fis1	45,49	DJ-1	Fis1	57320(Tax:10090)	66437(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	DJ-1 promotes the proteasomal degradation of Fis1 : implications of DJ-1 in neuronal protection .
16390825	0	DJ-1	0,4	HIPK1	20,25	DJ-1	HIPK1	11315	204851	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DJ-1 interacts with HIPK1 and affects H2O2-induced cell death .
21819105	0	DJ-1	85,89	Hsp90	116,121	DJ-1	Hsp90	11315	3320	Gene	Gene	START_ENTITY|nmod|interactions interactions|nmod|END_ENTITY	Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90 .
20510502	0	DJ-1	0,4	JNK	87,90	DJ-1	JNK	11315	5599	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	DJ-1 , a cancer and Parkinson 's _ disease associated protein , regulates autophagy through JNK pathway in cancer cells .
18689799	0	DJ-1	54,58	MnSOD	36,41	DJ-1	MnSOD	11315	6648	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha : regulation by SUMOylation and oxidation .
17015834	0	DJ-1	0,4	Nrf2	120,124	DJ-1	Nrf2	11315	4780	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	DJ-1 , a cancer - _ and_Parkinson 's _ disease-associated protein , stabilizes the antioxidant transcriptional master regulator Nrf2 .
26643903	0	DJ-1	12,16	Nrf2	17,21	DJ-1	Nrf2	117287(Tax:10116)	83619(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|amod|END_ENTITY	The role of DJ-1 / Nrf2 pathway in the pathogenesis of diabetic_nephropathy in rats .
25895590	0	DJ-1	132,136	Nuclear_Factor_Erythroid_2-Related_Factor_2	8,51	DJ-1	Nuclear Factor Erythroid 2-Related Factor 2	57320(Tax:10090)	18024(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Nuclear_Factor_Erythroid_2-Related_Factor_2 in the Oxidative Stress-Dependent Hypertension Associated With the Depletion of DJ-1 .
14662519	0	DJ-1	18,22	PARK7	24,29	DJ-1	PARK7	11315	11315	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of DJ-1 -LRB- PARK7 -RRB- in normal human CNS and idiopathic_Parkinson 's _ disease .
14872018	0	DJ-1	0,4	PARK7	6,11	DJ-1	PARK7	11315	11315	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	DJ-1 -LRB- PARK7 -RRB- mutations are less frequent than Parkin -LRB- PARK2 -RRB- mutations in early-onset Parkinson_disease .
15955416	0	DJ-1	85,89	PARK7	91,96	DJ-1	PARK7	11315	11315	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Development , characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 -LRB- PARK7 -RRB- protein .
23530187	0	DJ-1	30,34	PARK7	35,40	DJ-1	PARK7	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|protects protects|nsubj|END_ENTITY	Parkinson-susceptibility gene DJ-1 / PARK7 protects the murine heart from oxidative damage in vivo .
26634899	0	DJ-1	23,27	PARK7	28,33	DJ-1	PARK7	11315	11315	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Differential effect of DJ-1 / PARK7 on development of natural and induced regulatory T cells .
26965687	0	DJ-1	65,69	PARK7	58,63	DJ-1	PARK7	11315	11315	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	The effects of variants in the PARK2 -LRB- parkin -RRB- , PINK1 , and PARK7 -LRB- DJ-1 -RRB- genes along with evidence for their pathogenicity .
25383140	0	DJ-1	20,24	PRAK	0,4	DJ-1	PRAK	57320(Tax:10090)	17165(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PRAK interacts with DJ-1 and prevents oxidative stress-induced cell death .
15766664	0	DJ-1	0,4	PTEN	48,52	DJ-1	PTEN	11315	5728	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	DJ-1 , a novel regulator of the tumor suppressor PTEN .
17949781	0	DJ-1	32,36	PTEN	62,66	DJ-1	PTEN	11315	5728	Gene	Gene	role|nmod|START_ENTITY role|appos|regulator regulator|nmod|END_ENTITY	Expression and clinical role of DJ-1 , a negative regulator of PTEN , in ovarian_carcinoma .
19885556	0	DJ-1	74,78	PTEN	82,86	DJ-1	PTEN	11315	5728	Gene	Gene	binding|nmod|START_ENTITY transformation|nmod|binding transformation|nmod|END_ENTITY	Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN .
21823007	0	DJ-1	12,16	PTEN	71,75	DJ-1	PTEN	117287(Tax:10116)	50557(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	Upregulated DJ-1 promotes renal tubular EMT by suppressing cytoplasmic PTEN expression and Akt activation .
23151319	0	DJ-1	48,52	PTEN	78,82	DJ-1	PTEN	11315	5728	Gene	Gene	role|nmod|START_ENTITY role|appos|regulator regulator|nmod|END_ENTITY	Tumorigenesis role and clinical significance of DJ-1 , a negative regulator of PTEN , in supraglottic_squamous_cell_carcinoma .
23743200	0	DJ-1	0,4	PYCR1	21,26	DJ-1	PYCR1	11315	5831	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	DJ-1 cooperates with PYCR1 in cell protection against oxidative stress .
26995087	0	DJ-1	36,40	Park7	41,46	DJ-1	Park7	11315	11315	Gene	Gene	START_ENTITY|parataxis|prevents prevents|nsubj|END_ENTITY	The Parkinsonism-associated protein DJ-1 / Park7 prevents glycation damage in human keratinocyte .
24947010	0	DJ-1	0,4	RACK1	20,25	DJ-1	RACK1	11315	10399	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis .
24348900	0	DJ-1	120,124	RREB1	96,101	DJ-1	RREB1	57320(Tax:10090)	68750(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	DJ-1	58,62	RREB1	96,101	DJ-1	RREB1	57320(Tax:10090)	68750(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	DJ-1	86,90	RREB1	96,101	DJ-1	RREB1	57320(Tax:10090)	68750(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
25035075	0	DJ-1	15,19	SG2NA	0,5	DJ-1	SG2NA	11315	6801	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to protect cells from oxidative damage .
20634198	0	DJ-1	49,53	TRAF6	0,5	DJ-1	TRAF6	11315	7189	Gene	Gene	ubiquitination|nmod|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson 's _ disease brains .
11477070	0	DJ-1	0,4	androgen_receptor	30,47	DJ-1	androgen receptor	11315	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	DJ-1 positively regulates the androgen_receptor by impairing the binding of PIASx_alpha to the receptor .
17510388	0	DJ-1	0,4	androgen_receptor	11,28	DJ-1	androgen receptor	11315	367	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	DJ-1 binds androgen_receptor directly and mediates its activity in hormonally treated prostate_cancer cells .
19384955	0	DJ-1	19,23	hTERT	43,48	DJ-1	hTERT	11315	7015	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	The PTEN regulator DJ-1 is associated with hTERT expression in clear_cell_renal_cell_carcinoma .
22666465	0	DJ-1	71,75	low-density_lipoprotein_receptor	30,62	DJ-1	low-density lipoprotein receptor	57320(Tax:10090)	16835(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of low-density_lipoprotein_receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis .
15703819	0	DJ-1	0,4	p53	14,17	DJ-1	p53	11315	7157	Gene	Gene	restores|nsubj|START_ENTITY restores|ccomp|inhibited inhibited|nsubj|activity activity|compound|END_ENTITY	DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3 .
18042550	0	DJ-1	0,4	p53	49,52	DJ-1	p53	11315	7157	Gene	Gene	decreases|nsubj|START_ENTITY decreases|advcl|repressing repressing|dobj|activity activity|nummod|END_ENTITY	DJ-1 decreases Bax expression through repressing p53 transcriptional activity .
18339323	0	DJ-1	28,32	p53	44,47	DJ-1	p53	11315	7157	Gene	Gene	critical|nmod|START_ENTITY critical|xcomp|repress repress|dobj|activity activity|nummod|END_ENTITY	Sumoylation is critical for DJ-1 to repress p53 transcriptional activity .
20497343	0	DJ-1	0,4	p53	65,68	DJ-1	p53	11315	7157	Gene	Gene	expression|compound|START_ENTITY shows|nsubj|expression shows|dobj|correlation correlation|nmod|expression expression|compound|END_ENTITY	DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal_growth_factor_receptor amplification .
21725356	0	DJ-1	16,20	p53	44,47	DJ-1	p53	11315	7157	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nmod|loss loss|compound|END_ENTITY	Consequences of DJ-1 upregulation following p53 loss and cell transformation .
23149933	0	DJ-1	9,13	p53	23,26	DJ-1	p53	11315	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner .
23149933	0	DJ-1	9,13	p53	43,46	DJ-1	p53	11315	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner .
23418303	0	DJ-1	38,42	p53	121,124	DJ-1	p53	11315	7157	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	The Parkinson_disease-related protein DJ-1 counteracts mitochondrial impairment_induced_by_the_tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering .
22492997	0	DJ-1	0,4	thioredoxin_1	13,26	DJ-1	thioredoxin 1	11315	7295	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	DJ-1 induces thioredoxin_1 expression through the Nrf2 pathway .
12612053	0	DJBP	0,4	androgen_receptor	61,78	DJBP	androgen receptor	77627(Tax:10090)	11835(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	DJBP : a novel DJ-1-binding protein , negatively regulates the androgen_receptor by recruiting histone deacetylase complex , and DJ-1 antagonizes this inhibition by abrogation of this complex .
9224720	0	DJun	127,131	Jun_kinase	11,21	DJun	Jun kinase	36057(Tax:7227)	44801(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Drosophila Jun_kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure .
23246433	0	DKC1	68,72	SMUG1	38,43	DKC1	SMUG1	1736	23583	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control .
17822678	0	DKC1	0,4	c-MYC	57,62	DKC1	c-MYC	1736	4609	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	DKC1 is a direct and conserved transcriptional target of c-MYC .
23946118	0	DKC1	92,96	dyskeratosis_congenita_1	66,90	DKC1	dyskeratosis congenita 1	1736	1736	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Telomere phenotypes in females with heterozygous mutations in the dyskeratosis_congenita_1 -LRB- DKC1 -RRB- gene .
16491118	0	DKK-1	58,63	DICKKOPF-1	46,56	DKK-1	DICKKOPF-1	22943	22943	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 -LRB- DKK-1 -RRB- gene in human colorectal_cancer .
19657367	0	DKK-1	66,71	EPHX1	25,30	DKK-1	EPHX1	22943	2052	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Genetic polymorphisms of EPHX1 , Gsk3beta , TNFSF8 and myeloma cell DKK-1 expression linked to bone_disease in myeloma .
25459913	0	DKK-1	70,75	Growth_Hormone	134,148	DKK-1	Growth Hormone	22943	2688	Gene	Gene	START_ENTITY|nmod|Treatment Treatment|compound|END_ENTITY	Increased Serum and Bone Matrix Levels of the Secreted Wnt Antagonist DKK-1 in Patients With Growth_Hormone_Deficiency in Response to Growth_Hormone Treatment .
19815336	0	DKK1	46,50	DKK2	52,56	DKK1	DKK2	22943	27123	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
19815336	0	DKK1	46,50	DKK3	58,62	DKK1	DKK3	22943	27122	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
22815877	0	DKK1	71,75	Dickkopf-related_protein_1	43,69	DKK1	Dickkopf-related protein 1	22943	22943	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genistein affects histone modifications on Dickkopf-related_protein_1 -LRB- DKK1 -RRB- gene in SW480 human colon_cancer cell line .
19815336	0	DKK2	52,56	DKK1	46,50	DKK2	DKK1	27123	22943	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
19815336	0	DKK2	52,56	DKK3	58,62	DKK2	DKK3	27123	27122	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
19815336	0	DKK3	58,62	DKK1	46,50	DKK3	DKK1	27122	22943	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
19815336	0	DKK3	58,62	DKK2	52,56	DKK3	DKK2	27122	27123	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
21698294	0	DKKL1	49,54	SLXL1	0,5	DKKL1	SLXL1	50722(Tax:10090)	75140(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SLXL1 , a novel acrosomal protein , interacts with DKKL1 and is involved in fertilization in mice .
23507146	0	DLAD	15,19	HSF4	0,4	DLAD	HSF4	56629(Tax:10090)	26386(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HSF4 regulates DLAD expression and promotes lens de-nucleation .
12034501	0	DLC-1	68,73	Arhgap7	80,87	DLC-1	Arhgap7	50768(Tax:10090)	50768(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Gene structure , tissue expression , and linkage mapping of the mouse DLC-1 gene -LRB- Arhgap7 -RRB- .
16024604	0	DLC-1	19,24	RhoGAP	4,10	DLC-1	RhoGAP	50768(Tax:10090)	75404(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast_cancer cells .
25452387	0	DLC1	50,54	CDK5	0,4	DLC1	CDK5	10395	1020	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	CDK5 is a major regulator of the tumor suppressor DLC1 .
20384791	0	DLC1	60,64	Crossveinless-c	0,15	DLC1	Crossveinless-c	10395	41749(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Crossveinless-c , the Drosophila homolog of tumor suppressor DLC1 , regulates directional elongation of dendritic branches via down-regulating Rho1 activity .
23376848	0	DLC1	0,4	E-cadherin	27,37	DLC1	E-cadherin	10395	999	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	DLC1 induces expression of E-cadherin in prostate_cancer cells through Rho pathway and suppresses invasion .
26223867	0	DLC1	91,95	MicroRNA-106b	0,13	DLC1	MicroRNA-106b	10395	406900	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-106b promotes colorectal_cancer cell migration and invasion by directly targeting DLC1 .
19151751	0	DLC1	22,26	Rho-GAP	27,34	DLC1	Rho-GAP	10395	392	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities .
21372205	0	DLC1	0,4	S100A10	22,29	DLC1	S100A10	58834(Tax:10116)	81778(Tax:10116)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung_cancer cells through a RhoGAP-independent mechanism .
20069572	0	DLC1	77,81	Tensin_2	0,8	DLC1	Tensin 2	10395	23371	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Tensin_2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1 .
18981889	0	DLC1	54,58	deleted_in_liver_cancer_1	22,47	DLC1	deleted in liver cancer 1	10395	10395	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the deleted_in_liver_cancer_1 gene , DLC1 , as a candidate meningioma_tumor suppressor .
21969587	0	DLC1	48,52	deleted_in_liver_cancer_1	21,46	DLC1	deleted in liver cancer 1	10395	10395	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Full activity of the deleted_in_liver_cancer_1 -LRB- DLC1 -RRB- tumor suppressor depends on an LD-like motif that binds talin and focal_adhesion_kinase -LRB- FAK -RRB- .
19151751	0	DLC1	22,26	p120Ras-GAP	0,11	DLC1	p120Ras-GAP	10395	5921	Gene	Gene	protein|compound|START_ENTITY binds|dobj|protein binds|nsubj|END_ENTITY	p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities .
11937021	0	DLG	89,92	GUK-holder	69,79	DLG	GUK-holder	32083(Tax:7227)	53563(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder , a novel DLG binding protein .
9309137	0	DLG	20,23	beta-catenin	6,18	DLG	beta-catenin	32083(Tax:7227)	1499	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- APC , beta-catenin , DLG -RSB- .
24739954	0	DLG3	138,142	miR-1246	109,117	DLG3	miR-1246	1741	100302142	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression .
19795139	0	DLG3	24,28	synapse-associated_protein_102	47,77	DLG3	synapse-associated protein 102	1741	1741	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	A novel mutation in the DLG3 gene encoding the synapse-associated_protein_102 -LRB- SAP102 -RRB- causes non-syndromic_mental_retardation .
11714708	0	DLG4	59,63	CD46	33,37	DLG4	CD46	1742	4179	Gene	Gene	role|nmod|START_ENTITY interaction|dep|role interaction|nmod|END_ENTITY	A functional interaction between CD46 and DLG4 : a role for DLG4 in epithelial polarization .
21674725	0	DLG5	52,56	discs_large_homolog_5	24,45	DLG5	discs large homolog 5	9231	9231	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Increased expression of discs_large_homolog_5 gene -LRB- DLG5 -RRB- in ulcerative_colitis patients compared to healthy individuals .
25802931	0	DLK	15,18	Akt	0,3	DLK	Akt	26404(Tax:10090)	11651(Tax:10090)	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells .
25341110	0	DLK	41,44	Dual_Leucine_Zipper_Kinase	13,39	DLK	Dual leucine zipper kinase	7786	7786	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of Dual_Leucine_Zipper_Kinase -LRB- DLK , MAP3K12 -RRB- Inhibitors with Activity in Neurodegeneration Models .
20709675	0	DLK	71,74	dual_leucine_zipper_kinase	44,70	DLK	dual leucine zipper kinase	7786	7786	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Regulation of the JNK signaling pathway by dual_leucine_zipper_kinase DLK . -RSB- .
25359212	0	DLK-1	33,38	RHGF-1	0,6	DLK-1	RHGF-1	173128(Tax:6239)	184419(Tax:6239)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|appos|signaling	RHGF-1 / PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly .
15707898	0	DLK-1	16,21	RPM-1	73,78	DLK-1	RPM-1	173128(Tax:6239)	179259(Tax:6239)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development .
19808064	0	DLK/MUK/ZPK	44,55	dual_leucine_zipper-bearing_kinase	8,42	DLK/MUK/ZPK	dual leucine zipper-bearing kinase	25579(Tax:10116)	25579(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of dual_leucine_zipper-bearing_kinase -LRB- DLK/MUK/ZPK -RRB- in axonal growth .
23946446	0	DLK1	35,39	delta-like_1_homolog	13,33	DLK1	delta-like 1 homolog	13386(Tax:10090)	13386(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Dual role of delta-like_1_homolog -LRB- DLK1 -RRB- in skeletal muscle development and adult muscle regeneration .
22306741	0	DLK2	0,4	KLF4	36,40	DLK2	KLF4	106565(Tax:10090)	16600(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis .
21517260	0	DLL4	36,40	Delta-like_ligand_4	15,34	DLL4	Delta-like ligand 4	54567	54567	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of Delta-like_ligand_4 -LRB- DLL4 -RRB- with VEGF and HIF-1a expression in human glioma .
19413639	0	DLL4	83,87	delta-like_ligand_4	62,81	DLL4	delta-like ligand 4	54567	54567	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Nuclear and membrane expression of the angiogenesis regulator delta-like_ligand_4 -LRB- DLL4 -RRB- in normal and malignant human tissues .
8584231	0	DLST	79,83	dihydrolipoyl_succinyltransferase	44,77	DLST	dihydrolipoyl succinyltransferase	1743	1743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the chromosome 14q24 .3 dihydrolipoyl_succinyltransferase -LRB- DLST -RRB- gene in patients with early-onset Alzheimer_disease .
14671321	0	DLX-1	13,18	Smad4	34,39	DLX-1	Smad4	1745	4089	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells .
10818135	0	DM-20	67,72	proteolipid_protein	88,107	DM-20	proteolipid protein	18823(Tax:10090)	5354	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	The evolution of lipophilin genes from invertebrates to tetrapods : DM-20 can not replace proteolipid_protein in CNS myelin .
19339816	0	DM-W	17,21	Foxl2	30,35	DM-W	Foxl2	100137717(Tax:8355)	100188926(Tax:8355)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Xenopus W-linked DM-W induces Foxl2 and Cyp19 expression during ovary formation .
10399747	0	DM-associated_homeo_domain_protein	17,51	DMAHP	53,58	DM-associated homeo domain protein	DMAHP	147912	147912	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Reduction of the DM-associated_homeo_domain_protein -LRB- DMAHP -RRB- mRNA in different brain areas of myotonic_dystrophy patients .
17101631	0	DM1	28,31	SK3	10,13	DM1	SK3	1760	3782	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility .
16624843	0	DM2	0,3	ZNF9	96,100	DM2	ZNF9	7555	10793	Gene	Gene	expansions|nummod|START_ENTITY expansions|dep|evidence evidence|acl|CCUG CCUG|nmod|sequence sequence|nmod|processing processing|amod|END_ENTITY	DM2 intronic expansions : evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression .
20102514	0	DM2	31,34	ZNF9	72,76	DM2	ZNF9	7555	10793	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The myotonic_dystrophy type 2 -LRB- DM2 -RRB- gene product zinc_finger_protein_9 -LRB- ZNF9 -RRB- is associated with sarcomeres and normally localized in DM2 patients ' muscles .
26974341	0	DMA-1	44,49	KPC-1	53,58	DMA-1	KPC-1	187968(Tax:6239)	173051(Tax:6239)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Precise regulation of the guidance receptor DMA-1 by KPC-1 / Furin instructs dendritic_branching_decisions .
10399747	0	DMAHP	53,58	DM-associated_homeo_domain_protein	17,51	DMAHP	DM-associated homeo domain protein	147912	147912	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Reduction of the DM-associated_homeo_domain_protein -LRB- DMAHP -RRB- mRNA in different brain areas of myotonic_dystrophy patients .
14734556	0	DMAP1	20,25	RGS6	0,4	DMAP1	RGS6	55929	9628	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity .
24947515	0	DMAP1	24,29	Relish	101,107	DMAP1	Relish	37339(Tax:7227)	41087(Tax:7227)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	The chromatin regulator DMAP1 modulates activity of the nuclear factor B -LRB- NF-B -RRB- transcription factor Relish in the Drosophila innate immune response .
16624504	0	DMBT1	84,89	deleted_in_malignant_brain_tumors_1	42,77	DMBT1	deleted in malignant brain tumors 1	1755	1755	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of the porcine deleted_in_malignant_brain_tumors_1 gene -LRB- DMBT1 -RRB- .
25848046	0	DMBT1	66,71	salivary_agglutinin	40,59	DMBT1	salivary agglutinin	1755	1755	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evolution of the rapidly mutating human salivary_agglutinin gene -LRB- DMBT1 -RRB- and population subsistence strategy .
21903585	0	DMC1	77,81	RAD51-associated_protein_1	0,26	DMC1	RAD51-associated protein 1	11144	10635	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RAD51-associated_protein_1 -LRB- RAD51AP1 -RRB- interacts with the meiotic recombinase DMC1 through a conserved motif .
14764457	0	DMC1	89,93	p53	0,3	DMC1	p53	11144	7157	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|Protein Protein|compound|END_ENTITY	p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis .
25244321	0	DMD	42,45	Duchenne_Muscular_Dystrophy	13,40	DMD	Duchenne Muscular Dystrophy	1756	1756	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Screening of Duchenne_Muscular_Dystrophy -LRB- DMD -RRB- Mutations and Investigating Its Mutational Mechanism in Chinese Patients .
12810595	0	DMKP3	48,53	PTP-ER	99,105	DMKP3	PTP-ER	40081(Tax:7227)	37461(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER .
12489180	0	DMP-1	25,30	TGF_beta-1	0,10	DMP-1	TGF beta-1	13406(Tax:10090)	21803(Tax:10090)	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	TGF_beta-1 downregulates DMP-1 and DSPP in odontoblasts .
19796717	0	DMP-1	51,56	dentin_matrix_protein-1	26,49	DMP-1	dentin matrix protein-1	1758	1758	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Identification of a novel dentin_matrix_protein-1 -LRB- DMP-1 -RRB- mutation and dental_anomalies in a kindred with autosomal recessive hypophosphatemia .
22339660	0	DMP1	73,77	PHEX	60,64	DMP1	PHEX	1758	5251	Gene	Gene	ASARM|appos|START_ENTITY END_ENTITY|appos|ASARM	Regulation of bone-renal mineral and energy metabolism : the PHEX , FGF23 , DMP1 , MEPE ASARM pathway .
9177774	0	DMP1	109,113	dentin_matrix_acidic_phosphoprotein_1	70,107	DMP1	dentin matrix acidic phosphoprotein 1	1758	1758	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Elucidation of the sequence and the genomic organization of the human dentin_matrix_acidic_phosphoprotein_1 -LRB- DMP1 -RRB- gene : exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II .
10744713	0	DMP1	61,65	dentin_matrix_protein_1	36,59	DMP1	dentin matrix protein 1	25312(Tax:10116)	25312(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of rat dentin_matrix_protein_1 -LRB- DMP1 -RRB- gene and its 5 ' - upstream region .
12470941	0	DMP1	40,44	dentin_matrix_protein_1	15,38	DMP1	dentin matrix protein 1	1758	1758	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Utility of the dentin_matrix_protein_1 -LRB- DMP1 -RRB- gene for resolving mammalian intraordinal phylogenetic relationships .
12489182	0	DMP1	55,59	dentin_matrix_protein_1	30,53	DMP1	dentin matrix protein 1	25312(Tax:10116)	25312(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of dentin_matrix_protein_1 -LRB- DMP1 -RRB- by AP-1 -LRB- c-fos/c-jun -RRB- factors .
12733719	0	DMP1	55,59	dentin_matrix_protein_1	30,53	DMP1	dentin matrix protein 1	13406(Tax:10090)	13406(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mechanical loading stimulates dentin_matrix_protein_1 -LRB- DMP1 -RRB- expression in osteocytes in vivo .
15268908	0	DMP1	39,43	dentin_matrix_protein_1	14,37	DMP1	dentin matrix protein 1	1758	1758	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of dentin_matrix_protein_1 -LRB- DMP1 -RRB- during fracture healing .
15316863	0	DMP1	39,43	dentin_matrix_protein_1	14,37	DMP1	dentin matrix protein 1	13406(Tax:10090)	13406(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of dentin_matrix_protein_1 -LRB- DMP1 -RRB- in nonmineralized tissues .
25158192	0	DMP1	55,59	dentin_matrix_protein_1	30,53	DMP1	dentin matrix protein 1	25312(Tax:10116)	25312(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of dentin_matrix_protein_1 -LRB- DMP1 -RRB- in odontoblasts and osteoblasts .
21062982	0	DMP1	18,22	epidermal_growth_factor_receptor_2	32,66	DMP1	epidermal growth factor receptor 2	1758	2064	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Critical roles of DMP1 in human epidermal_growth_factor_receptor_2 / neu-Arf-p53 signaling and breast_cancer development .
17987120	0	DMPK	43,47	myotonic_dystrophy_protein_kinase	8,41	DMPK	myotonic dystrophy protein kinase	13400(Tax:10090)	13400(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of myotonic_dystrophy_protein_kinase -LRB- DMPK -RRB- in glucose homeostasis and muscle insulin action .
8288237	0	DMPK	46,50	myotonic_dystrophy_protein_kinase	11,44	DMPK	myotonic dystrophy protein kinase	1760	1760	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Absence of myotonic_dystrophy_protein_kinase -LRB- DMPK -RRB- mRNA as a result of a triplet repeat expansion in myotonic_dystrophy .
21621532	0	DMRT1	0,5	Stra8	58,63	DMRT1	Stra8	1761	346673	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary .
19706893	0	DMT1	30,34	Divalent_metal_transporter_1	0,28	DMT1	Divalent metal transporter 1	4891	4891	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Divalent_metal_transporter_1 -LRB- DMT1 -RRB- regulation by Ndfip1 prevents metal toxicity in human neurons .
15880641	0	DMT1	124,128	HFE	81,84	DMT1	HFE	4891	3077	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Transferrin receptor co-localizes and interacts with the hemochromatosis factor -LRB- HFE -RRB- and the divalent_metal_transporter-1 -LRB- DMT1 -RRB- in trophoblast cells .
19706893	0	DMT1	30,34	Ndfip1	50,56	DMT1	Ndfip1	4891	80762	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Divalent_metal_transporter_1 -LRB- DMT1 -RRB- regulation by Ndfip1 prevents metal toxicity in human neurons .
27048792	0	DMT1	56,60	Ndfip2	0,6	DMT1	Ndfip2	18174(Tax:10090)	76273(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver .
16232120	0	DMT1	53,57	P19	65,68	DMT1	P19	18174(Tax:10090)	83430(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Post-translational and transcriptional regulation of DMT1 during P19 embryonic_carcinoma cell differentiation by retinoic_acid .
16091455	0	DMT1	37,41	SLC11A2	43,50	DMT1	SLC11A2	4891	4891	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Functional consequences of the human DMT1 -LRB- SLC11A2 -RRB- mutation on protein expression and iron uptake .
15355847	0	DMT1	54,58	Slc11a2	60,67	DMT1	Slc11a2	25715(Tax:10116)	25715(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of divalent metal transporter DMT1 -LRB- Slc11a2 -RRB- in the spermatogenic epithelium of the developing and adult rat testis .
10644324	0	DMT1	46,50	divalent_metal_transporter_1	16,44	DMT1	divalent metal transporter 1	24906(Tax:10116)	24906(Tax:10116)	Gene	Gene	Localisation|appos|START_ENTITY Localisation|nmod|END_ENTITY	Localisation of divalent_metal_transporter_1 -LRB- DMT1 -RRB- to the microvillus membrane of rat duodenal enterocytes in iron_deficiency , but to hepatocytes in iron_overload .
19655216	0	DMT1	70,74	divalent_metal_transporter_1	40,68	DMT1	divalent metal transporter 1	24906(Tax:10116)	24906(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Increased hippocampal expression of the divalent_metal_transporter_1 -LRB- DMT1 -RRB- mRNA variants 1B and + IRE and DMT1 protein after NMDA-receptor stimulation or spatial memory training .
8499920	0	DM_kinase	58,67	myotonic_dystrophy	38,56	DM kinase	myotonic dystrophy	13400(Tax:10090)	1760	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and genomic sequence of the myotonic_dystrophy -LRB- DM_kinase -RRB- gene .
26107252	0	DNA-PK	77,83	AIM2	33,37	DNA-PK	AIM2	19090(Tax:10090)	383619(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt .
22131882	0	DNA-PK	0,6	AKT	16,19	DNA-PK	AKT	5591	207	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance .
10072187	0	DNA-PK	66,72	DNA-dependent_protein_kinase	36,64	DNA-PK	DNA-dependent protein kinase	5591	5591	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Heat sensitivity of double-stranded DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- activity .
10098733	0	DNA-PK	58,64	DNA-dependent_protein_kinase	28,56	DNA-PK	DNA-dependent protein kinase	5591	5591	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Ku70/80 gene expression and DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- activity do not correlate with double-strand break -LRB- dsb -RRB- repair capacity and cellular radiosensitivity in normal human fibroblasts .
10214916	0	DNA-PK	48,54	DNA-dependent_protein_kinase	18,46	DNA-PK	DNA-dependent protein kinase	19090(Tax:10090)	19090(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regulation of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- activity in eukaryotic cells .
11597411	0	DNA-PK	107,113	DNA-dependent_protein_kinase	77,105	DNA-PK	DNA-dependent protein kinase	5591	5591	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Synthesis , crystal structure determination , and biological properties of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- inhibitor 3-cyano-6-hydrazonomethyl-5 - -LRB- 4-pyridyl -RRB- pyrid - -LSB- 1H -RSB- -2 - one -LRB- OK-1035 -RRB- .
15060176	0	DNA-PK	58,64	DNA-dependent_protein_kinase	28,56	DNA-PK	DNA-dependent protein kinase	5591	5591	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- by the radiosensitizing agent caffeine .
21216595	0	DNA-PK	30,36	DNA-dependent_protein_kinase	0,28	DNA-PK	DNA-dependent protein kinase	5591	5591	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- inhibitors : structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain .
22814419	0	DNA-PK	68,74	DNA-dependent_protein_kinase	38,66	DNA-PK	DNA-dependent protein kinase	5591	5591	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Potent enantioselective inhibition of DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- by atropisomeric chromenone derivatives .
8060336	0	DNA-PK	66,72	DNA-stimulated_protein_kinase	35,64	DNA-PK	DNA-stimulated protein kinase	5591	5591	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Demonstration of a double-stranded DNA-stimulated_protein_kinase -LRB- DNA-PK -RRB- inhibitory activity in human HL-60 leukemia cells .
16567133	0	DNA-PK	0,6	H2AX	30,34	DNA-PK	H2AX	5591	3014	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells .
23557743	0	DNA-PK	0,6	IGFBP-3	26,33	DNA-PK	IGFBP-3	5591	3486	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	DNA-PK phosphorylation of IGFBP-3 is required to prevent apoptosis in retinal endothelial cells cultured in high glucose .
11867762	0	DNA-PK	55,61	Interferon_regulatory_factor-3	0,30	DNA-PK	Interferon regulatory factor-3	5591	3661	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Interferon_regulatory_factor-3 is an in vivo target of DNA-PK .
17241822	0	DNA-PK	93,99	Xrcc4	57,62	DNA-PK	Xrcc4	5591	7518	Gene	Gene	complex|nmod|START_ENTITY complex|amod|END_ENTITY	Interaction of the Ku heterodimer with the DNA_ligase_IV / Xrcc4 complex and its regulation by DNA-PK .
16046194	0	DNA-PK	0,6	histone_H2AX	54,66	DNA-PK	histone H2AX	5591	3014	Gene	Gene	responsible|nsubj|START_ENTITY responsible|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	DNA-PK is responsible for enhanced phosphorylation of histone_H2AX under hypertonic conditions .
19024322	0	DNA-PK	24,30	hnRNP_B1	12,20	DNA-PK	hnRNP B1	5591	3181	Gene	Gene	activity|amod|START_ENTITY Effects|nmod|activity Effects|nmod|END_ENTITY	-LSB- Effects of hnRNP_B1 on DNA-PK activity , cell cycle and apoptosis in human lung_adenocarcinoma cell line A549 -RSB- .
22977523	0	DNA-PK_catalytic_subunit	62,86	BAAT1	47,52	DNA-PK catalytic subunit	BAAT1	5591	221927	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK_catalytic_subunit .
22239103	0	DNA-PKcs	0,8	Aire	24,28	DNA-PKcs	Aire	19090(Tax:10090)	11634(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DNA-PKcs interacts with Aire and regulates the expression of toll-like receptors in RAW264 .7 cells .
15678105	0	DNA-PKcs	0,8	Akt	54,57	DNA-PKcs	Akt	19090(Tax:10090)	11651(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	DNA-PKcs , but not TLR9 , is required for activation of Akt by CpG-DNA .
25152407	0	DNA-PKcs	0,8	Akt	26,29	DNA-PKcs	Akt	5591	207	Gene	Gene	important|nsubj|START_ENTITY important|nmod|activation activation|compound|END_ENTITY	DNA-PKcs is important for Akt activation and gemcitabine resistance in PANC-1 pancreatic_cancer cells .
17786318	0	DNA-PKcs	70,78	DNA-dependent_protein_kinase_catalytic_subunit	22,68	DNA-PKcs	DNA-dependent protein kinase catalytic subunit	5591	5591	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression of DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- during gastric_carcinogenesis and its clinical implications on gastric_cancer .
19589246	0	DNA-PKcs	158,166	DNA-dependent_protein_kinase_catalytic_subunit	110,156	DNA-PKcs	DNA-dependent protein kinase catalytic subunit	5591	5591	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Significance of phosphatase_and_tensin_homologue -LRB- PTEN -RRB- , O -LRB- 6 -RRB- - methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- , and DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- protein expression in gynaecomastia .
19956487	0	DNA-PKcs	56,64	DNA-dependent_protein_kinase_catalytic_subunit	8,54	DNA-PKcs	DNA-dependent protein kinase catalytic subunit	5591	5591	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- expression in gastric_cancers .
24390088	0	DNA-PKcs	116,124	DNA-dependent_protein_kinase_catalytic_subunit	68,114	DNA-PKcs	DNA-dependent protein kinase catalytic subunit	5591	5591	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Repair of radiation damage of U2OS osteosarcoma cells is related to DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- activity .
24844881	0	DNA-PKcs	115,123	DNA-dependent_protein_kinase_catalytic_subunit	67,113	DNA-PKcs	DNA-dependent protein kinase catalytic subunit	5591	5591	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Polo-like_kinase_1 -LRB- PLK1 -RRB- and protein_phosphatase_6 -LRB- PP6 -RRB- regulate DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- phosphorylation in mitosis .
24972688	0	DNA-PKcs	102,110	DNA-dependent_protein_kinase_catalytic_subunit	54,100	DNA-PKcs	DNA-dependent protein kinase catalytic subunit	5591	5591	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Adverse prognostic and predictive significance of low DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- expression in early-stage breast_cancers .
9205842	0	DNA-PKcs	149,157	DNA-dependent_protein_kinase_catalytic_subunit	96,142	DNA-PKcs	DNA-dependent protein kinase catalytic subunit	5591	5591	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the promoter region , first ten exons and nine intron-exon boundaries of the DNA-dependent_protein_kinase_catalytic_subunit gene , DNA-PKcs -LRB- XRCC7 -RRB- .
23533581	0	DNA-PKcs	15,23	IL-6	31,35	DNA-PKcs	IL-6	5591	3569	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells .
24166892	0	DNA-PKcs	0,8	PLK1	25,29	DNA-PKcs	PLK1	5591	5347	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis .
11839092	0	DNA-PKcs	103,111	Prkdc	96,101	DNA-PKcs	Prkdc	395376(Tax:9031)	395376(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence analysis of 193.4 and 83.9 kbp of mouse and chicken genomic DNAs containing the entire Prkdc -LRB- DNA-PKcs -RRB- gene .
24530422	0	DNA-PKcs	39,47	Sp1	15,18	DNA-PKcs	Sp1	5591	6667	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA_ligase_IV transcription of daunorubicin-resistant_leukemia cell lines .
20704701	0	DNA-PKcs	99,107	scFv	72,76	DNA-PKcs	scFv	5591	652070	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo .
17449080	0	DNA-binding_protein	51,70	DBP	46,49	DNA-binding protein	DBP	284390	284390	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of a baculovirus lacking the DBP -LRB- DNA-binding_protein -RRB- gene .
7657701	0	DNA-binding_protein	8,27	myelin_basic_protein	73,93	DNA-binding protein	myelin basic protein	26386(Tax:10090)	17196(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	A 39-kD DNA-binding_protein from mouse brain stimulates transcription of myelin_basic_protein gene in oligodendrocytic cells .
7682655	0	DNA-binding_protein	28,47	myelin_basic_protein	76,96	DNA-binding protein	myelin basic protein	26386(Tax:10090)	17196(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	A developmentally regulated DNA-binding_protein from mouse brain stimulates myelin_basic_protein gene expression .
18941233	0	DNA-dependent_activator_of_IFN_regulatory_factors	108,157	NF-kappa_B	78,88	DNA-dependent activator of IFN regulatory factors	NF-kappa B	81030	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa_B activation via the DNA-dependent_activator_of_IFN_regulatory_factors .
15668230	0	DNA-dependent_protein_kinase	22,50	CHK2	14,18	DNA-dependent protein kinase	CHK2	5591	11200	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of CHK2 by DNA-dependent_protein_kinase .
15509799	0	DNA-dependent_protein_kinase	29,57	Cds1	8,12	DNA-dependent protein kinase	Cds1	373602(Tax:8355)	398179(Tax:8355)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Xenopus Cds1 is regulated by DNA-dependent_protein_kinase and ATR during the cell cycle checkpoint response to double-stranded DNA ends .
10072187	0	DNA-dependent_protein_kinase	36,64	DNA-PK	66,72	DNA-dependent protein kinase	DNA-PK	5591	5591	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Heat sensitivity of double-stranded DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- activity .
10098733	0	DNA-dependent_protein_kinase	28,56	DNA-PK	58,64	DNA-dependent protein kinase	DNA-PK	5591	5591	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Ku70/80 gene expression and DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- activity do not correlate with double-strand break -LRB- dsb -RRB- repair capacity and cellular radiosensitivity in normal human fibroblasts .
10214916	0	DNA-dependent_protein_kinase	18,46	DNA-PK	48,54	DNA-dependent protein kinase	DNA-PK	19090(Tax:10090)	19090(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regulation of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- activity in eukaryotic cells .
11597411	0	DNA-dependent_protein_kinase	77,105	DNA-PK	107,113	DNA-dependent protein kinase	DNA-PK	5591	5591	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Synthesis , crystal structure determination , and biological properties of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- inhibitor 3-cyano-6-hydrazonomethyl-5 - -LRB- 4-pyridyl -RRB- pyrid - -LSB- 1H -RSB- -2 - one -LRB- OK-1035 -RRB- .
15060176	0	DNA-dependent_protein_kinase	28,56	DNA-PK	58,64	DNA-dependent protein kinase	DNA-PK	5591	5591	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Selective inhibition of the DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- by the radiosensitizing agent caffeine .
21216595	0	DNA-dependent_protein_kinase	0,28	DNA-PK	30,36	DNA-dependent protein kinase	DNA-PK	5591	5591	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- inhibitors : structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain .
22814419	0	DNA-dependent_protein_kinase	38,66	DNA-PK	68,74	DNA-dependent protein kinase	DNA-PK	5591	5591	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Potent enantioselective inhibition of DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- by atropisomeric chromenone derivatives .
11731412	0	DNA-dependent_protein_kinase	24,52	DNA_repair_protein	56,74	DNA-dependent protein kinase	DNA repair protein	5591	442459	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of DNA-dependent_protein_kinase , a DNA_repair_protein , during human colon_carcinogenesis .
9372844	0	DNA-dependent_protein_kinase	20,48	KIP	70,73	DNA-dependent protein kinase	KIP	19090(Tax:10090)	23991(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between DNA-dependent_protein_kinase and a novel protein , KIP .
24194952	0	DNA-dependent_protein_kinase	0,28	Lmx1a	65,70	DNA-dependent protein kinase	Lmx1a	19090(Tax:10090)	110648(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	DNA-dependent_protein_kinase is a context dependent regulator of Lmx1a and midbrain specification .
9371494	0	DNA-dependent_protein_kinase	25,53	Mdm-2	0,5	DNA-dependent protein kinase	Mdm-2	5591	4193	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Mdm-2 phosphorylation by DNA-dependent_protein_kinase prevents interaction with p53 .
14704337	0	DNA-dependent_protein_kinase	0,28	RNA_helicase_A	77,91	DNA-dependent protein kinase	RNA helicase A	5591	1660	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- phosphorylates nuclear DNA_helicase_II / RNA_helicase_A and hnRNP proteins in an RNA-dependent manner .
10064605	0	DNA-dependent_protein_kinase	82,110	RPA	75,78	DNA-dependent protein kinase	RPA	5591	6117	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent_protein_kinase and dissociates RPA : DNA-PK complexes .
20157594	0	DNA-dependent_protein_kinase	17,45	SIRT6	0,5	DNA-dependent protein kinase	SIRT6	5591	51548	Gene	Gene	stabilizes|xcomp|START_ENTITY stabilizes|nsubj|END_ENTITY	SIRT6 stabilizes DNA-dependent_protein_kinase at chromatin for DNA double-strand break repair .
19656952	0	DNA-dependent_protein_kinase	55,83	heterogeneous_nuclear_ribonucleoprotein_A1	101,143	DNA-dependent protein kinase	heterogeneous nuclear ribonucleoprotein A1	5591	3178	Gene	Gene	START_ENTITY|acl|phosphorylate phosphorylate|dobj|END_ENTITY	The human telomerase RNA component , hTR , activates the DNA-dependent_protein_kinase to phosphorylate heterogeneous_nuclear_ribonucleoprotein_A1 .
12547193	0	DNA-dependent_protein_kinase	52,80	p460	31,35	DNA-dependent protein kinase	p460	5591	5591	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	Coordinated assembly of Ku and p460 subunits of the DNA-dependent_protein_kinase on DNA ends is necessary for XRCC4-ligase IV recruitment .
20204287	0	DNA-dependent_protein_kinase	120,148	p53	102,105	DNA-dependent protein kinase	p53	5591	7157	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Radiosensitivity profiles from a panel of ovarian_cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent_protein_kinase activities .
24365180	0	DNA-dependent_protein_kinase_catalytic_subunit	0,46	Akt	112,115	DNA-dependent protein kinase catalytic subunit	Akt	5591	207	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|compound|END_ENTITY	DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- - SIN1 association mediates ultraviolet B -LRB- UVB -RRB- - induced Akt Ser-473 phosphorylation and skin cell survival .
17786318	0	DNA-dependent_protein_kinase_catalytic_subunit	22,68	DNA-PKcs	70,78	DNA-dependent protein kinase catalytic subunit	DNA-PKcs	5591	5591	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression of DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- during gastric_carcinogenesis and its clinical implications on gastric_cancer .
19589246	0	DNA-dependent_protein_kinase_catalytic_subunit	110,156	DNA-PKcs	158,166	DNA-dependent protein kinase catalytic subunit	DNA-PKcs	5591	5591	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Significance of phosphatase_and_tensin_homologue -LRB- PTEN -RRB- , O -LRB- 6 -RRB- - methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- , and DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- protein expression in gynaecomastia .
19956487	0	DNA-dependent_protein_kinase_catalytic_subunit	8,54	DNA-PKcs	56,64	DNA-dependent protein kinase catalytic subunit	DNA-PKcs	5591	5591	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- expression in gastric_cancers .
24390088	0	DNA-dependent_protein_kinase_catalytic_subunit	68,114	DNA-PKcs	116,124	DNA-dependent protein kinase catalytic subunit	DNA-PKcs	5591	5591	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Repair of radiation damage of U2OS osteosarcoma cells is related to DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- activity .
24844881	0	DNA-dependent_protein_kinase_catalytic_subunit	67,113	DNA-PKcs	115,123	DNA-dependent protein kinase catalytic subunit	DNA-PKcs	5591	5591	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Polo-like_kinase_1 -LRB- PLK1 -RRB- and protein_phosphatase_6 -LRB- PP6 -RRB- regulate DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- phosphorylation in mitosis .
24972688	0	DNA-dependent_protein_kinase_catalytic_subunit	54,100	DNA-PKcs	102,110	DNA-dependent protein kinase catalytic subunit	DNA-PKcs	5591	5591	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Adverse prognostic and predictive significance of low DNA-dependent_protein_kinase_catalytic_subunit -LRB- DNA-PKcs -RRB- expression in early-stage breast_cancers .
9205842	0	DNA-dependent_protein_kinase_catalytic_subunit	96,142	DNA-PKcs	149,157	DNA-dependent protein kinase catalytic subunit	DNA-PKcs	5591	5591	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the promoter region , first ten exons and nine intron-exon boundaries of the DNA-dependent_protein_kinase_catalytic_subunit gene , DNA-PKcs -LRB- XRCC7 -RRB- .
11280730	0	DNA-dependent_protein_kinase_catalytic_subunit	115,161	Prkdc	108,113	DNA-dependent protein kinase catalytic subunit	Prkdc	19090(Tax:10090)	19090(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Elevated breast_cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc -LRB- DNA-dependent_protein_kinase_catalytic_subunit -RRB- gene .
23325550	0	DNA-dependent_protein_kinase_catalytic_subunit	18,64	lymphocyte_enhancer_factor_1	99,127	DNA-dependent protein kinase catalytic subunit	lymphocyte enhancer factor 1	5591	51176	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of DNA-dependent_protein_kinase_catalytic_subunit as a novel interaction partner of lymphocyte_enhancer_factor_1 .
8060336	0	DNA-stimulated_protein_kinase	35,64	DNA-PK	66,72	DNA-stimulated protein kinase	DNA-PK	5591	5591	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Demonstration of a double-stranded DNA-stimulated_protein_kinase -LRB- DNA-PK -RRB- inhibitory activity in human HL-60 leukemia cells .
14643435	0	DNA2	26,30	SGS1	20,24	DNA2	SGS1	856569(Tax:4932)	855228(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Evidence that yeast SGS1 , DNA2 , SRS2 , and FOB1 interact to maintain rDNA stability .
9745018	0	DNA43	143,148	MCM10	150,155	DNA43	MCM10	854656(Tax:4932)	854656(Tax:4932)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	The essential schizosaccharomyces_pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces_cerevisiae DNA43 -LRB- MCM10 -RRB- gene .
12142464	0	DNAH11	17,23	axonemal_heavy_chain_dynein_type_11	25,60	DNAH11	axonemal heavy chain dynein type 11	8701	8701	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the DNAH11 -LRB- axonemal_heavy_chain_dynein_type_11 -RRB- gene cause one form of situs inversus totalis and most likely primary ciliary_dyskinesia .
23408083	0	DNAJA1	22,28	Hsp40	6,11	DNAJA1	Hsp40	3301	171221	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Human Hsp40 proteins , DNAJA1 and DNAJA2 , as potential targets of the immune response triggered by bacterial DnaJ in rheumatoid_arthritis .
24361594	0	DNAJB1	0,6	MDM2	18,22	DNAJB1	MDM2	3337	4193	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner .
26239118	0	DNAJB1	0,6	MIG6	28,32	DNAJB1	MIG6	3337	54206	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	DNAJB1 negatively regulates MIG6 to promote epidermal_growth_factor_receptor signaling .
25233908	0	DNAJB13	0,7	HSP40	19,24	DNAJB13	HSP40	69387(Tax:10090)	81489(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	DNAJB13 , a type II HSP40 family member , localizes to the spermatids and spermatozoa during mouse spermatogenesis .
25146923	0	DNAJB9	29,35	p53	75,78	DNAJB9	p53	4189	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53 .
24122553	0	DNAJC12	17,24	Hsc70	34,39	DNAJC12	Hsc70	56521	3312	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The co-chaperone DNAJC12 binds to Hsc70 and is upregulated by endoplasmic reticulum stress .
16049974	0	DNAJD1	32,38	MCJ	27,30	DNAJD1	MCJ	29103	29103	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Epigenetic inactivation of MCJ -LRB- DNAJD1 -RRB- in malignant paediatric_brain_tumours .
15039383	0	DNAM-1	31,37	CD226	39,44	DNAM-1	CD226	10666	225825(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of DNAM-1 -LRB- CD226 -RRB- interaction with its ligands PVR -LRB- CD155 -RRB- and nectin-2 -LRB- PRR-2 / CD112 -RRB- .
26675069	0	DNAM-1	14,20	CD226	22,27	DNAM-1	CD226	10666	10666	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of DNAM-1 -LRB- CD226 -RRB- on inflammatory monocytes .
20937876	0	DNAM-1	44,50	DNAX_accessory_molecule-1	17,42	DNAM-1	DNAX accessory molecule-1	225825(Tax:10090)	225825(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of DNAX_accessory_molecule-1 -LRB- DNAM-1 -RRB- in the development of acute_graft-versus-host_disease in mice .
23161903	0	DNAM-1	66,72	DNAX_accessory_molecule-1	39,64	DNAM-1	DNAX accessory molecule-1	225825(Tax:10090)	225825(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of the adhesion receptor DNAX_accessory_molecule-1 -LRB- DNAM-1 -RRB- in the development of inflammation-driven dermal fibrosis in a mouse model of systemic_sclerosis .
23229555	0	DNAS1L3	148,155	caspase-activated_deoxyribonuclease	66,101	DNAS1L3	caspase-activated deoxyribonuclease	1776	1677	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated_deoxyribonuclease and the poly -LRB- ADP-ribose -RRB- _ polymerase-regulated DNAS1L3 , an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis .
16771825	0	DNASE1	52,58	deoxyribonuclease_I	26,45	DNASE1	deoxyribonuclease I	1773	1773	Gene	Gene	promoters|compound|START_ENTITY promoters|amod|END_ENTITY	Characterization of human deoxyribonuclease_I gene -LRB- DNASE1 -RRB- promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation .
7789176	0	DNASE_1	62,69	deoxyribonuclease_I	36,55	DNASE 1	deoxyribonuclease I	1773	1773	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal assignment of the human deoxyribonuclease_I gene , DNASE_1 -LRB- DNL1 -RRB- , to band 16p13 .3 using the polymerase chain reaction .
20937876	0	DNAX_accessory_molecule-1	17,42	DNAM-1	44,50	DNAX accessory molecule-1	DNAM-1	225825(Tax:10090)	225825(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of DNAX_accessory_molecule-1 -LRB- DNAM-1 -RRB- in the development of acute_graft-versus-host_disease in mice .
23161903	0	DNAX_accessory_molecule-1	39,64	DNAM-1	66,72	DNAX accessory molecule-1	DNAM-1	225825(Tax:10090)	225825(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of the adhesion receptor DNAX_accessory_molecule-1 -LRB- DNAM-1 -RRB- in the development of inflammation-driven dermal fibrosis in a mouse model of systemic_sclerosis .
9888853	0	DNA_5-methylcytosine_transferase	8,40	fos	67,70	DNA 5-methylcytosine transferase	fos	1786	2353	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of DNA_5-methylcytosine_transferase in cell transformation by fos .
24984242	0	DNA_Ligase_IV	0,13	XRCC4	24,29	DNA Ligase IV	XRCC4	3981	7518	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nummod|END_ENTITY	DNA_Ligase_IV regulates XRCC4 nuclear localization .
26576226	0	DNA_Repair_Enzyme	23,40	MUTYH	14,19	DNA Repair Enzyme	MUTYH	3981	4595	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MUTYH , a DNA_Repair_Enzyme , in Renal Proximal Tubular Epithelial Cells .
20554522	0	DNA_Topoisomerase_IIbeta	14,38	heterogeneous_nuclear_ribonucleoprotein_U	78,119	DNA Topoisomerase IIbeta	heterogeneous nuclear ribonucleoprotein U	7155	3192	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of DNA_Topoisomerase_IIbeta through RNA-dependent association with heterogeneous_nuclear_ribonucleoprotein_U -LRB- hnRNP_U -RRB- .
12954226	0	DNA_binding_protein	11,30	CBP	56,59	DNA binding protein	CBP	284390	1387	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Adenovirus DNA_binding_protein inhibits SrCap-activated CBP and CREB-mediated transcription .
1429518	0	DNA_binding_protein	54,73	RBP-J_kappa	75,86	DNA binding protein	RBP-J kappa	26386(Tax:10090)	19664(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biochemical and immunological characterization of the DNA_binding_protein -LRB- RBP-J_kappa -RRB- to mouse J kappa recombination signal sequence .
11581372	0	DNA_binding_protein	11,30	SNF2-related_CBP_activator_protein	50,84	DNA binding protein	SNF2-related CBP activator protein	7335	10847	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Adenovirus DNA_binding_protein interacts with the SNF2-related_CBP_activator_protein -LRB- SrCap -RRB- and inhibits SrCap-mediated transcription .
19749785	0	DNA_binding_protein_A	22,43	dbpA	45,49	DNA binding protein A	dbpA	8531	8531	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of human DNA_binding_protein_A -LRB- dbpA -RRB- in gastric_cancer cells .
26410533	0	DNA_damage-binding_protein_2	34,62	Pyruvate_kinase_M2	0,18	DNA damage-binding protein 2	Pyruvate kinase M2	1643	5315	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pyruvate_kinase_M2 interacts with DNA_damage-binding_protein_2 and reduces cell survival upon UV irradiation .
26825372	0	DNA_damage-inducible_transcript_4	0,33	mTOR	107,111	DNA damage-inducible transcript 4	mTOR	140942(Tax:10116)	21977(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	DNA_damage-inducible_transcript_4 -LRB- DDIT4 -RRB- mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes .
11425895	0	DNA_fragmentation_factor_40	24,51	Caspase-activated_DNase	0,23	DNA fragmentation factor 40	Caspase-activated DNase	84359(Tax:10116)	84359(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Caspase-activated_DNase / DNA_fragmentation_factor_40 mediates apoptotic DNA fragmentation in transient_cerebral_ischemia and in neuronal_cultures .
20225158	0	DNA_helicase_II	38,53	RNA_helicase_A	55,69	DNA helicase II	RNA helicase A	7520	1660	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization of nuclear DNA_helicase_II -LRB- RNA_helicase_A -RRB- .
11222755	0	DNA_helicase_V	24,38	far_upstream_element-binding_protein	48,84	DNA helicase V	far upstream element-binding protein	8880	8880	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human DNA_helicase_V with the far_upstream_element-binding_protein .
1639065	0	DNA_ligase_I	24,36	casein_kinase_II	64,80	DNA ligase I	casein kinase II	100124507(Tax:9913)	1457	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mammalian DNA_ligase_I through phosphorylation by casein_kinase_II .
10047779	0	DNA_ligase_IV	11,24	XRCC4	78,83	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	protein|compound|START_ENTITY Absence|nmod|protein Absence|dep|evidence evidence|nmod|stabilization stabilization|nmod|END_ENTITY	Absence of DNA_ligase_IV protein in XR-1 cells : evidence for stabilization by XRCC4 .
11029705	0	DNA_ligase_IV	12,25	XRCC4	144,149	DNA ligase IV	XRCC4	835822(Tax:3702)	821885(Tax:3702)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|homologue homologue|nmod|END_ENTITY	Arabidopsis DNA_ligase_IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4 .
12218164	0	DNA_ligase_IV	46,59	XRCC4	60,65	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of human autoantibodies to the DNA_ligase_IV / XRCC4 complex and mapping of an autoimmune_epitope to a potential regulatory region .
17290226	0	DNA_ligase_IV	6,19	XRCC4	0,5	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	ligate|nsubj|START_ENTITY END_ENTITY|parataxis|ligate	XRCC4 : DNA_ligase_IV can ligate incompatible DNA ends and can ligate across gaps .
18782835	0	DNA_ligase_IV	8,21	XRCC4	89,94	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	Loss|nmod|START_ENTITY prevents|nsubj|Loss prevents|nmod|END_ENTITY	Loss of DNA_ligase_IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF .
18952251	0	DNA_ligase_IV	40,53	XRCC4	54,59	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	dissociation|nmod|START_ENTITY dissociation|dep|END_ENTITY	E1B 55k-independent dissociation of the DNA_ligase_IV / XRCC4 complex by E4 34k during adenovirus_infection .
9242410	0	DNA_ligase_IV	12,25	XRCC4	63,68	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	Activity|nmod|START_ENTITY stimulated|nsubj|Activity stimulated|nmod|protein protein|compound|END_ENTITY	Activity of DNA_ligase_IV stimulated by complex formation with XRCC4 protein in mammalian cells .
9259561	0	DNA_ligase_IV	70,83	XRCC4	49,54	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA_ligase_IV .
9705934	0	DNA_ligase_IV	0,13	XRCC4	23,28	DNA ligase IV	XRCC4	3981	7518	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	DNA_ligase_IV binds to XRCC4 via a motif located between rather than within its BRCT domains .
15385968	0	DNA_ligase_IV	86,99	Xrcc4	0,5	DNA ligase IV	Xrcc4	3981	7518	Gene	Gene	links|nmod|START_ENTITY links|nsubj|physically physically|compound|END_ENTITY	Xrcc4 physically links DNA end processing by polynucleotide_kinase to DNA ligation by DNA_ligase_IV .
17241822	0	DNA_ligase_IV	43,56	Xrcc4	57,62	DNA ligase IV	Xrcc4	3981	7518	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|complex complex|amod|END_ENTITY	Interaction of the Ku heterodimer with the DNA_ligase_IV / Xrcc4 complex and its regulation by DNA-PK .
9837999	0	DNA_ligase_IV	146,159	YOR005c	114,121	DNA ligase IV	YOR005c	3981	854166(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces_cerevisiae open reading frame YOR005c , a homolog of mammalian DNA_ligase_IV .
20398054	0	DNA_methyltransferase	0,21	DNMT3b	22,28	DNA methyltransferase	DNMT3b	1786	1789	Gene	Gene	START_ENTITY|dobj|overexpression overexpression|amod|END_ENTITY	DNA_methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell_lymphomas .
11482456	0	DNA_methyltransferase	44,65	Dnmt1	67,72	DNA methyltransferase	Dnmt1	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Proliferation stage-dependent expression of DNA_methyltransferase -LRB- Dnmt1 -RRB- in mouse small intestine .
11942627	0	DNA_methyltransferase	14,35	Dnmt1	37,42	DNA methyltransferase	Dnmt1	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of DNA_methyltransferase -LRB- Dnmt1 -RRB- in testicular germ cells during development of mouse embryo .
21980391	0	DNA_methyltransferase	16,37	TGF-b	0,5	DNA methyltransferase	TGF-b	1786	7040	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGF-b regulates DNA_methyltransferase expression in prostate_cancer , correlates with aggressive capabilities , and predicts disease recurrence .
24993472	0	DNA_methyltransferase	26,47	TMS1	61,65	DNA methyltransferase	TMS1	1786	10955	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Arsenic_trioxide inhibits DNA_methyltransferase and restores TMS1 gene expression in K562 cells .
25886310	0	DNA_methyltransferase_1	0,23	C/ebpa	42,48	DNA methyltransferase 1	C/ebpa	30430(Tax:7955)	140815(Tax:7955)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	DNA_methyltransferase_1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish .
17492476	0	DNA_methyltransferase_1	39,62	CD4	77,80	DNA methyltransferase 1	CD4	1786	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Prevalence of ZAP-70 , LAT , SLP-76 , and DNA_methyltransferase_1 expression in CD4 + T cells of patients with systemic_lupus_erythematosus .
18977197	0	DNA_methyltransferase_1	56,79	Cyclin-dependent_kinase-like_5	0,30	DNA methyltransferase 1	Cyclin-dependent kinase-like 5	13433(Tax:10090)	382253(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cyclin-dependent_kinase-like_5 binds and phosphorylates DNA_methyltransferase_1 .
17196739	0	DNA_methyltransferase_1	24,47	DNMT1	49,54	DNA methyltransferase 1	DNMT1	1786	1786	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Increased expression of DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein in uterine_cervix_squamous_cell_carcinoma and its precursor lesion .
21947282	0	DNA_methyltransferase_1	23,46	DNMT1	48,53	DNA methyltransferase 1	DNMT1	1786	1786	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	SIRT1 deacetylates the DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein and alters its activities .
26261487	0	DNA_methyltransferase_1	18,41	DNMT1	43,48	DNA methyltransferase 1	DNMT1	1786	1786	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Overexpression of DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein in astrocytic_tumour and its correlation with O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- expression .
12799438	0	DNA_methyltransferase_1	23,46	Dnmt1	48,53	DNA methyltransferase 1	Dnmt1	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	Transcription|nmod|START_ENTITY Transcription|appos|END_ENTITY	Transcription of mouse DNA_methyltransferase_1 -LRB- Dnmt1 -RRB- is regulated by both E2F-Rb-HDAC-dependent and - independent pathways .
22898998	0	DNA_methyltransferase_1	98,121	Dnmt1	123,128	DNA methyltransferase 1	Dnmt1	1786	1786	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MicroRNA-140 acts as a liver_tumor suppressor by controlling NF-kB activity by directly targeting DNA_methyltransferase_1 -LRB- Dnmt1 -RRB- expression .
22967183	0	DNA_methyltransferase_1	0,23	Dnmt1	25,30	DNA methyltransferase 1	Dnmt1	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	DNA_methyltransferase_1 -LRB- Dnmt1 -RRB- mutation affects Snrpn imprinting in the mouse male germ line .
24515776	0	DNA_methyltransferase_1	55,78	MEG3	19,23	DNA methyltransferase 1	MEG3	1786	55384	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	MiR-148a regulates MEG3 in gastric_cancer by targeting DNA_methyltransferase_1 .
24515776	0	DNA_methyltransferase_1	55,78	MiR-148a	0,8	DNA methyltransferase 1	MiR-148a	1786	406940	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MiR-148a regulates MEG3 in gastric_cancer by targeting DNA_methyltransferase_1 .
23125218	0	DNA_methyltransferase_1	21,44	MicroRNA-152	0,12	DNA methyltransferase 1	MicroRNA-152	1786	406943	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-152 targets DNA_methyltransferase_1 in NiS-transformed cells via a feedback mechanism .
23867713	0	DNA_methyltransferase_1	8,31	eNOS	47,51	DNA methyltransferase 1	eNOS	1786	4846	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Role of DNA_methyltransferase_1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses .
18164808	0	DNA_methyltransferase_1_and_3b	85,115	E-cadherin	45,55	DNA methyltransferase 1 and 3b	E-cadherin	1789	999	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Hepatitis_C virus core protein downregulates E-cadherin expression via activation of DNA_methyltransferase_1_and_3b .
24282625	0	DNA_methyltransferase_3A	66,90	DNMT3A	92,98	DNA methyltransferase 3A	DNMT3A	444984(Tax:10116)	444984(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Phenotypic switching induced by damaged matrix is associated with DNA_methyltransferase_3A -LRB- DNMT3A -RRB- activity and nuclear localization in smooth_muscle_cells -LRB- SMC -RRB- .
15362956	0	DNA_methyltransferase_3A	40,64	Sp3	81,84	DNA methyltransferase 3A	Sp3	1788	6670	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of the human DNA_methyltransferase_3A and 3B genes by Sp3 and Sp1 zinc finger proteins .
18029387	0	DNA_methyltransferase_3B	0,24	DNMT3B	26,32	DNA methyltransferase 3B	DNMT3B	1789	1789	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	DNA_methyltransferase_3B -LRB- DNMT3B -RRB- mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development , neurogenesis and immune function .
21909138	0	DNA_methyltransferase_3B	25,49	MTSS1	0,5	DNA methyltransferase 3B	MTSS1	1789	9788	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	MTSS1 , a novel target of DNA_methyltransferase_3B , functions as a tumor suppressor in hepatocellular_carcinoma .
19502167	0	DNA_methyltransferase_3b	13,37	FHIT	41,45	DNA methyltransferase 3b	FHIT	1789	2272	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Influence of DNA_methyltransferase_3b on FHIT expression and DNA methylation of the FHIT promoter region in hepatoma SMMC-7721 cells .
19567080	0	DNA_methyltransferase_3b	14,38	cyclin_D1	60,69	DNA methyltransferase 3b	cyclin D1	1789	595	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	-LSB- Influence of DNA_methyltransferase_3b on the expression of cyclin_D1 gene and methylation of its promoters in human hepatocellular_carcinoma cells -RSB- .
15632075	0	DNA_methyltransferase_3b	0,24	histone_deacetylase_2	107,128	DNA methyltransferase 3b	histone deacetylase 2	444985(Tax:10116)	84577(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	DNA_methyltransferase_3b regulates nerve_growth_factor-induced differentiation of PC12 cells by recruiting histone_deacetylase_2 .
17483406	0	DNA_polymerase_alpha	9,29	ATR	59,62	DNA polymerase alpha	ATR	42553(Tax:7227)	32608(Tax:7227)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Reducing DNA_polymerase_alpha in the absence of Drosophila ATR leads to P53-dependent apoptosis and developmental_defects .
1703528	0	DNA_polymerase_alpha	89,109	DNA_polymerase_delta	26,46	DNA polymerase alpha	DNA polymerase delta	5422	5424	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human DNA_polymerase_delta and its immunochemical relationships with DNA_polymerase_alpha and epsilon .
10656792	1	DNA_polymerase_alpha	81,101	Replication_factor_C	30,50	DNA polymerase alpha	Replication factor C	5422	5981	Gene	Gene	abrogates|nmod|START_ENTITY abrogates|nsubj|END_ENTITY	Replication_factor_C abrogates primer synthesis by DNA_polymerase_alpha at a critical length .
3490907	0	DNA_polymerase_alpha	20,40	alpha_1-antichymotrypsin	44,68	DNA polymerase alpha	alpha 1-antichymotrypsin	5422	12	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human DNA_polymerase_alpha by alpha_1-antichymotrypsin .
1375330	0	DNA_polymerase_alpha	89,109	single-stranded_DNA-binding_protein	10,45	DNA polymerase alpha	single-stranded DNA-binding protein	5422	6117	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	HeLa cell single-stranded_DNA-binding_protein increases the accuracy of DNA synthesis by DNA_polymerase_alpha in vitro .
7194115	0	DNA_polymerase_alpha	58,78	terminal_deoxynucleotidyl_transferase	15,52	DNA polymerase alpha	terminal deoxynucleotidyl transferase	5422	1791	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|END_ENTITY	Cooperation of terminal_deoxynucleotidyl_transferase with DNA_polymerase_alpha in the replication of ultraviolet-irradiated DNA .
25561897	0	DNA_polymerase_beta	45,64	POLB	66,70	DNA polymerase beta	POLB	5423	5423	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Clinical significance of a point mutation in DNA_polymerase_beta -LRB- POLB -RRB- gene in gastric_cancer .
15963946	0	DNA_polymerase_beta	32,51	TEIF	55,59	DNA polymerase beta	TEIF	5423	57410	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of DNA_polymerase_beta by TEIF .
15172990	0	DNA_polymerase_beta	0,19	TRF2	35,39	DNA polymerase beta	TRF2	5423	7014	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DNA_polymerase_beta interacts with TRF2 and induces telomere_dysfunction in a murine mammary cell line .
8702497	0	DNA_polymerase_beta	24,43	cAMP_response_element-binding_protein-1	114,153	DNA polymerase beta	cAMP response element-binding protein-1	5423	1385	Gene	Gene	promoter|compound|START_ENTITY Activation|nmod|promoter Activation|nmod|END_ENTITY	Activation of the human DNA_polymerase_beta promoter by a DNA-alkylating agent through induced phosphorylation of cAMP_response_element-binding_protein-1 .
22561893	0	DNA_polymerase_beta	0,19	pol_b	21,26	DNA polymerase beta	pol b	5423	5423	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	DNA_polymerase_beta -LRB- pol_b -RRB- inhibitors : a comprehensive overview .
10792046	0	DNA_polymerase_delta	23,43	Cyclin_A	0,8	DNA polymerase delta	Cyclin A	5424	890	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Cyclin_A activates the DNA_polymerase_delta - dependent elongation machinery in vitro : A parvovirus DNA replication model .
1703528	0	DNA_polymerase_delta	26,46	DNA_polymerase_alpha	89,109	DNA polymerase delta	DNA polymerase alpha	5424	5422	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human DNA_polymerase_delta and its immunochemical relationships with DNA_polymerase_alpha and epsilon .
2886367	0	DNA_polymerase_delta	35,55	PCNA	8,12	DNA polymerase delta	PCNA	5424	5111	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Cyclin -LRB- PCNA , auxiliary protein of DNA_polymerase_delta -RRB- is a central component of the pathway -LRB- s -RRB- leading to DNA replication and cell division .
9177181	0	DNA_polymerase_delta	93,113	Proliferating_cell_nuclear_antigen	0,34	DNA polymerase delta	Proliferating cell nuclear antigen	5424	5111	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Proliferating_cell_nuclear_antigen promotes DNA synthesis past template lesions by mammalian DNA_polymerase_delta .
11027336	0	DNA_polymerase_delta	24,44	Werner_protein	0,14	DNA polymerase delta	Werner protein	5424	7486	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Werner_protein recruits DNA_polymerase_delta to the nucleolus .
10196469	0	DNA_polymerase_delta	80,100	XlCdc1	20,26	DNA polymerase delta	XlCdc1	447518(Tax:8355)	379793(Tax:8355)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Characterisation of XlCdc1 , a Xenopus homologue of the small -LRB- PolD2 -RRB- subunit of DNA_polymerase_delta ; identification of ten conserved regions I-X based on protein sequence comparisons across ten eukaryotic species .
10480866	0	DNA_polymerase_delta	102,122	p125	66,70	DNA polymerase delta	p125	5424	11196	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Direct interaction of proliferating_cell_nuclear_antigen with the p125 catalytic subunit of mammalian DNA_polymerase_delta .
12522211	0	DNA_polymerase_delta	82,102	p50	67,70	DNA polymerase delta	p50	5424	4790	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Identification of a novel protein , PDIP38 , that interacts with the p50 subunit of DNA_polymerase_delta and proliferating_cell_nuclear_antigen .
16934752	0	DNA_polymerase_delta	28,48	p66	4,7	DNA polymerase delta	p66	5424	10714	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	The p66 and p12 subunits of DNA_polymerase_delta are modified by ubiquitin and ubiquitin-like proteins .
18157942	0	DNA_polymerase_delta	48,68	p66	34,37	DNA polymerase delta	p66	5424	10714	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of the C subunit -LRB- p66 -RRB- of human DNA_polymerase_delta .
10480866	0	DNA_polymerase_delta	102,122	proliferating_cell_nuclear_antigen	22,56	DNA polymerase delta	proliferating cell nuclear antigen	5424	5111	Gene	Gene	subunit|nmod|START_ENTITY interaction|nmod|subunit interaction|nmod|END_ENTITY	Direct interaction of proliferating_cell_nuclear_antigen with the p125 catalytic subunit of mammalian DNA_polymerase_delta .
11595739	0	DNA_polymerase_delta	173,193	proliferating_cell_nuclear_antigen	13,47	DNA polymerase delta	proliferating cell nuclear antigen	5424	5111	Gene	Gene	subunit|nmod|START_ENTITY present|nmod|subunit Mediation|dep|present Mediation|nmod|END_ENTITY	Mediation of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- - dependent DNA replication through a conserved p21 -LRB- Cip1 -RRB- - like PCNA-binding motif present in the third subunit of human DNA_polymerase_delta .
11986310	0	DNA_polymerase_delta	83,103	proliferating_cell_nuclear_antigen	22,56	DNA polymerase delta	proliferating cell nuclear antigen	5424	5111	Gene	Gene	subunit|nmod|START_ENTITY interaction|nmod|subunit interaction|nmod|END_ENTITY	Direct interaction of proliferating_cell_nuclear_antigen with the small subunit of DNA_polymerase_delta .
2563372	0	DNA_polymerase_delta	36,56	proliferating_cell_nuclear_antigen	96,130	DNA polymerase delta	proliferating cell nuclear antigen	5424	5111	Gene	Gene	form|nmod|START_ENTITY form|acl:relcl|insensitive insensitive|xcomp|END_ENTITY	Characterization of a large form of DNA_polymerase_delta from HeLa cells that is insensitive to proliferating_cell_nuclear_antigen .
2891114	0	DNA_polymerase_delta	109,129	proliferating_cell_nuclear_antigen	20,54	DNA polymerase delta	proliferating cell nuclear antigen	5424	5111	Gene	Gene	protein|nmod|START_ENTITY activity|nmod|protein neutralizes|dobj|activity neutralizes|nsubj|Autoantibody Autoantibody|nmod|END_ENTITY	Autoantibody to the proliferating_cell_nuclear_antigen neutralizes the activity of the auxiliary protein for DNA_polymerase_delta .
7915843	0	DNA_polymerase_delta	127,147	proliferating_cell_nuclear_antigen	46,80	DNA polymerase delta	proliferating cell nuclear antigen	5424	5111	Gene	Gene	holoenzyme|compound|START_ENTITY catalyzed|nmod|holoenzyme replication|acl|catalyzed replication|compound|END_ENTITY	Cdk-interacting_protein_1 directly binds with proliferating_cell_nuclear_antigen and inhibits DNA replication catalyzed by the DNA_polymerase_delta holoenzyme .
8679582	0	DNA_polymerase_delta	14,34	proliferating_cell_nuclear_antigen	36,70	DNA polymerase delta	proliferating cell nuclear antigen	5424	5111	Gene	Gene	complex|compound|START_ENTITY complex|dep|END_ENTITY	The mammalian DNA_polymerase_delta -- proliferating_cell_nuclear_antigen -- template-primer complex : molecular characterization by direct binding .
9092615	0	DNA_polymerase_delta	60,80	proliferating_cell_nuclear_antigen	90,124	DNA polymerase delta	proliferating cell nuclear antigen	7508	5111	Gene	Gene	interaction|nmod|START_ENTITY required|nmod|interaction required|nmod|END_ENTITY	The small subunit is required for functional interaction of DNA_polymerase_delta with the proliferating_cell_nuclear_antigen .
16611994	0	DNA_polymerase_kappa	16,36	Rad18	0,5	DNA polymerase kappa	Rad18	56626(Tax:10090)	58186(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Rad18 regulates DNA_polymerase_kappa and is required for recovery from S-phase checkpoint-mediated arrest .
15520469	0	DNA_polymerase_mu	24,41	Pol_mu	43,49	DNA polymerase mu	Pol mu	27434	27434	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of human DNA_polymerase_mu -LRB- Pol_mu -RRB- in a Burkitt 's _ lymphoma cell line affects the somatic hypermutation rate .
16462773	0	DNA_repair_protein	11,29	BRCA1	41,46	DNA repair protein	BRCA1	442459	672	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	BACH1 is a DNA_repair_protein supporting BRCA1 damage response .
11731412	0	DNA_repair_protein	56,74	DNA-dependent_protein_kinase	24,52	DNA repair protein	DNA-dependent protein kinase	442459	5591	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of DNA-dependent_protein_kinase , a DNA_repair_protein , during human colon_carcinogenesis .
18076572	0	DNA_supercoiling_factor	0,23	Abdominal-B	77,88	DNA supercoiling factor	Abdominal-B	38145(Tax:7227)	47763(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	DNA_supercoiling_factor positively regulates expression of the homeotic gene Abdominal-B in Drosophila_melanogaster .
10469141	0	DNA_topoisomerase_I	54,73	apolipoprotein_B	9,25	DNA topoisomerase I	apolipoprotein B	64550(Tax:10116)	338	Gene	Gene	START_ENTITY|nsubj|gene gene|compound|END_ENTITY	Purified apolipoprotein_B gene regulatory factor-3 is DNA_topoisomerase_I .
11557042	0	DNA_topoisomerase_III_alpha	40,67	upstream_stimulatory_factor	87,114	DNA topoisomerase III alpha	upstream stimulatory factor	7156	7391	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Cell type-dependent regulation of human DNA_topoisomerase_III_alpha gene expression by upstream_stimulatory_factor 2 .
20479117	0	DNGR-1	26,32	BDCA3	34,39	DNGR-1	BDCA3	283420	7056	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of human DNGR-1 + BDCA3 + leukocytes as putative equivalents of mouse CD8alpha + dendritic cells .
23641861	0	DNJ-27	19,25	ERdj5	26,31	DNJ-27	ERdj5	173065(Tax:6239)	54431	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Protective role of DNJ-27 / ERdj5 in Caenorhabditis_elegans models of human neurodegenerative_diseases .
18452187	0	DNMBP	49,54	dynamin-binding_protein	24,47	DNMBP	dynamin-binding protein	23268	23268	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Association analysis of dynamin-binding_protein -LRB- DNMBP -RRB- on chromosome 10q with late onset Alzheimer 's _ disease in a large caucasian UK sample .
20980350	0	DNMT	120,124	DNMT	20,24	DNMT	DNMT	1786	1786	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Effects of specific DNMT gene depletion on cancer_cell_transformation_and_breast_cancer cell invasion ; toward selective DNMT inhibitors .
20980350	0	DNMT	20,24	DNMT	120,124	DNMT	DNMT	1786	1786	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Effects of specific DNMT gene depletion on cancer_cell_transformation_and_breast_cancer cell invasion ; toward selective DNMT inhibitors .
23897429	0	DNMT1	0,5	ATP-citrate_lyase	22,39	DNMT1	ATP-citrate lyase	1786	47	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	DNMT1 is regulated by ATP-citrate_lyase and maintains methylation patterns during adipocyte differentiation .
26606905	0	DNMT1	103,108	ApoE	112,116	DNMT1	ApoE	13433(Tax:10090)	11816(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE -LRB- - / - -RRB- mice .
18194272	0	DNMT1	44,49	CD4	72,75	DNMT1	CD4	1786	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Transcript levels of DNA methyltransferases DNMT1 , DNMT3A and DNMT3B in CD4 + T cells from patients with systemic_lupus_erythematosus .
23706494	0	DNMT1	106,111	CD4	46,49	DNMT1	CD4	1786	920	Gene	Gene	activity|compound|START_ENTITY systemic_lupus_erythematosus|nmod|activity enhances|nmod|systemic_lupus_erythematosus enhances|dobj|hypomethylation hypomethylation|nmod|cells cells|compound|END_ENTITY	Ultraviolet B enhances DNA hypomethylation of CD4 + T cells in systemic_lupus_erythematosus via inhibiting DNMT1 catalytic activity .
26770634	0	DNMT1	38,43	CD4	69,72	DNMT1	CD4	1786	920	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	A correlation study on the effects of DNMT1 on methylation levels in CD4 -LRB- + -RRB- T cells of SLE patients .
17196739	0	DNMT1	49,54	DNA_methyltransferase_1	24,47	DNMT1	DNA methyltransferase 1	1786	1786	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Increased expression of DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein in uterine_cervix_squamous_cell_carcinoma and its precursor lesion .
21947282	0	DNMT1	48,53	DNA_methyltransferase_1	23,46	DNMT1	DNA methyltransferase 1	1786	1786	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	SIRT1 deacetylates the DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein and alters its activities .
26261487	0	DNMT1	43,48	DNA_methyltransferase_1	18,41	DNMT1	DNA methyltransferase 1	1786	1786	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Overexpression of DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein in astrocytic_tumour and its correlation with O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- expression .
22975348	0	DNMT1	25,30	ERa	0,3	DNMT1	ERa	1786	2099	Gene	Gene	expression|compound|START_ENTITY regulated|dobj|expression regulated|nsubj|END_ENTITY	ERa positively regulated DNMT1 expression by binding to the gene promoter region in human breast_cancer MCF-7 cells .
26606905	0	DNMT1	103,108	FABP4	66,71	DNMT1	FABP4	13433(Tax:10090)	11770(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE -LRB- - / - -RRB- mice .
22110720	0	DNMT1	14,19	GLI1	48,52	DNMT1	GLI1	1786	2735	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic_cancer .
10888872	0	DNMT1	0,5	HDAC2	12,17	DNMT1	HDAC2	1786	3066	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	DNMT1 binds HDAC2 and a new co-repressor , DMAP1 , to form a complex at replication foci .
17931718	0	DNMT1	0,5	HESX1	65,70	DNMT1	HESX1	13433(Tax:10090)	15209(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DNMT1 interacts with the developmental transcriptional repressor HESX1 .
17934516	0	DNMT1	67,72	ICBP90	37,43	DNMT1	ICBP90	1786	29128	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression .
24434851	0	DNMT1	21,26	MBD4	0,4	DNMT1	MBD4	1786	8930	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress .
26676363	0	DNMT1	62,67	MEG3	45,49	DNMT1	MEG3	1786	55384	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas .
21846773	0	DNMT1	48,53	SNAIL1	14,20	DNMT1	SNAIL1	1786	6615	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context .
16861352	0	DNMT1	65,70	STAT3	0,5	DNMT1	STAT3	1786	6774	Gene	Gene	gene|appos|START_ENTITY transcription|nmod|gene induces|dobj|transcription induces|nsubj|END_ENTITY	STAT3 induces transcription of the DNA methyltransferase 1 gene -LRB- DNMT1 -RRB- in malignant T lymphocytes .
24675762	0	DNMT1	111,116	STAT3	121,126	DNMT1	STAT3	1786	6774	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation .
26847351	0	DNMT1	73,78	STAT3	53,58	DNMT1	STAT3	1786	6774	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Transcriptional repression of SOCS3 mediated by IL-6 / STAT3 signaling via DNMT1 promotes pancreatic_cancer growth and metastasis .
24211420	0	DNMT1	32,37	Smad7	14,19	DNMT1	Smad7	84350(Tax:10116)	81516(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver_fibrosis in rats .
23463006	0	DNMT1	14,19	UHRF1	0,5	DNMT1	UHRF1	13433(Tax:10090)	18140(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9 .
16769694	0	DNMT1	34,39	XIST	0,4	DNMT1	XIST	1786	7503	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	XIST repression in the absence of DNMT1 and DNMT3B .
19275888	0	DNMT1	31,36	p21	0,3	DNMT1	p21	1786	1026	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p21 -LRB- WAF1 -RRB- negatively regulates DNMT1 expression in mammalian cells .
23431054	0	DNMT1	0,5	p53	16,19	DNMT1	p53	1786	7157	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis .
22489043	0	DNMT3A	33,39	CBL	28,31	DNMT3A	CBL	1788	867	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
24282625	0	DNMT3A	92,98	DNA_methyltransferase_3A	66,90	DNMT3A	DNA methyltransferase 3A	444984(Tax:10116)	444984(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Phenotypic switching induced by damaged matrix is associated with DNA_methyltransferase_3A -LRB- DNMT3A -RRB- activity and nuclear localization in smooth_muscle_cells -LRB- SMC -RRB- .
22489043	0	DNMT3A	33,39	IDH1	41,45	DNMT3A	IDH1	1788	3417	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
26486081	0	DNMT3A	15,21	IDH1/2	0,6	DNMT3A	IDH1/2	1788	3417;3418	Gene	Gene	mutations|nummod|START_ENTITY END_ENTITY|nmod|mutations	IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients : a study by the acute leukemia french association .
22489043	0	DNMT3A	33,39	IDH2	47,51	DNMT3A	IDH2	1788	3418	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	DNMT3A	33,39	JAK2	53,57	DNMT3A	JAK2	1788	3717	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	DNMT3A	33,39	MPL	59,62	DNMT3A	MPL	1788	4352	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	DNMT3A	33,39	NF1	64,67	DNMT3A	NF1	1788	4763	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
19139273	0	DNMT3A	21,27	SALL3	0,5	DNMT3A	SALL3	1788	27164	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular_carcinoma .
22489043	0	DNMT3A	33,39	SF3B1	69,74	DNMT3A	SF3B1	1788	23451	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
26059451	0	DNMT3A	17,23	STAT5A	0,6	DNMT3A	STAT5A	1788	6776	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	STAT5A regulates DNMT3A in CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- AML cells .
18029387	0	DNMT3B	26,32	DNA_methyltransferase_3B	0,24	DNMT3B	DNA methyltransferase 3B	1789	1789	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	DNA_methyltransferase_3B -LRB- DNMT3B -RRB- mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development , neurogenesis and immune function .
20454457	0	DNMT3B	20,26	HOXB13	0,6	DNMT3B	HOXB13	13436(Tax:10090)	15408(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	HOXB13 , a target of DNMT3B , is methylated at an upstream CpG island , and functions as a tumor suppressor in primary colorectal_tumors .
19723495	0	DNMT3B	55,61	PGC-1alpha	27,37	DNMT3B	PGC-1alpha	1789	10891	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density .
17017004	0	DNMT3B	63,69	p14ARF	20,26	DNMT3B	p14ARF	1789	1029	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|expression expression|nmod|END_ENTITY	Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal_squamous_cell_carcinomas .
15105426	0	DNMT3L	0,6	Dnmt3a	50,56	DNMT3L	Dnmt3a	29947	1788	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction .
20398054	0	DNMT3b	22,28	DNA_methyltransferase	0,21	DNMT3b	DNA methyltransferase	1789	1786	Gene	Gene	overexpression|amod|START_ENTITY END_ENTITY|dobj|overexpression	DNA_methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell_lymphomas .
26556862	0	DNMT3b	62,68	MiR-221	0,7	DNMT3b	MiR-221	1789	407006	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MiR-221 promotes stemness of breast_cancer cells by targeting DNMT3b .
7615541	0	DNase-I	23,30	porphobilinogen_deaminase	65,90	DNase-I	porphobilinogen deaminase	13419(Tax:10090)	15288(Tax:10090)	Gene	Gene	sites|amod|START_ENTITY sites|nmod|gene gene|compound|END_ENTITY	Functional analysis of DNase-I hypersensitive sites at the mouse porphobilinogen_deaminase gene locus .
26065428	0	DNaseI	85,91	IL-1b	62,67	DNaseI	IL-1b	13419(Tax:10090)	3553	Gene	Gene	Translocation|compound|START_ENTITY Promotes|dobj|Translocation Promotes|nsubj|END_ENTITY	TNFa Amplifies DNaseI Expression in Renal Tubular Cells while IL-1b Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form .
26065428	0	DNaseI	15,21	TNFa	0,4	DNaseI	TNFa	13419(Tax:10090)	7124	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TNFa Amplifies DNaseI Expression in Renal Tubular Cells while IL-1b Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form .
21335080	0	DNaseI	63,69	deoxyribonuclease_I	42,61	DNaseI	deoxyribonuclease I	1773	1773	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Enhanced properties of discrete pulmonary deoxyribonuclease_I -LRB- DNaseI -RRB- loaded PLGA nanoparticles during encapsulation and activity determination .
15002038	0	DNaseY	14,20	actinin-alpha4	33,47	DNaseY	actinin-alpha4	116687(Tax:10116)	63836(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of DNaseY activity by actinin-alpha4 during apoptosis .
3336367	0	DNase_I	0,7	apolipoprotein_B	68,84	DNase I	apolipoprotein B	13419(Tax:10090)	338	Gene	Gene	sites|amod|START_ENTITY sites|nmod|gene gene|compound|END_ENTITY	DNase_I - and micrococcal nuclease-hypersensitive sites in the human apolipoprotein_B gene are tissue specific .
16877481	0	DNase_I	66,73	deoxyribonuclease_I	45,64	DNase I	deoxyribonuclease I	1773	1773	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of Gln222Arg polymorphism in the deoxyribonuclease_I -LRB- DNase_I -RRB- gene with myocardial_infarction in Japanese patients .
7556418	0	DNase_I	44,51	deoxyribonuclease_I	23,42	DNase I	deoxyribonuclease I	13419(Tax:10090)	13419(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Tissue distribution of deoxyribonuclease_I -LRB- DNase_I -RRB- activity level in mice and its sexual dimorphism .
7762978	0	DNase_I	44,51	deoxyribonuclease_I	23,42	DNase I	deoxyribonuclease I	1773	1773	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the human deoxyribonuclease_I -LRB- DNase_I -RRB- gene : identification of the nucleotide substitution that generates its classical genetic polymorphism .
21807894	0	DNase_II-alpha	13,27	Klf1	0,4	DNase II-alpha	Klf1	13423(Tax:10090)	16596(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY affects|dobj|expression affects|nsubj|END_ENTITY	Klf1 affects DNase_II-alpha expression in the central macrophage of a fetal liver erythroblastic island : a non-cell-autonomous role in definitive erythropoiesis .
14985111	0	DOC-1R	88,94	CDK2-associated_protein-1	19,44	DOC-1R	CDK2-associated protein-1	10263	8099	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the CDK2-associated_protein-1 , p12 -LRB- DOC-1 / CDK2AP1 -RRB- , with its homolog , p14 -LRB- DOC-1R -RRB- .
14985111	0	DOC-1R	88,94	CDK2AP1	56,63	DOC-1R	CDK2AP1	10263	8099	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the CDK2-associated_protein-1 , p12 -LRB- DOC-1 / CDK2AP1 -RRB- , with its homolog , p14 -LRB- DOC-1R -RRB- .
11371563	1	DOC-2	85,90	Grb2	154,158	DOC-2	Grb2	1601	2885	Gene	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	DOC-2 / DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2 .
11906161	0	DOC-2	0,5	myosin_VI	37,46	DOC-2	myosin VI	1601	4646	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	DOC-2 / DAB2 is the binding partner of myosin_VI .
19033398	0	DOC2B	0,5	syntaxin-4	15,25	DOC2B	syntaxin-4	8447	6810	Gene	Gene	START_ENTITY|dep|protein protein|amod|END_ENTITY	DOC2B : a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes .
19118547	0	DOCK180	63,70	Ankyrin_repeat_domain_28	0,24	DOCK180	Ankyrin repeat domain 28	1793	23243	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Ankyrin_repeat_domain_28 -LRB- ANKRD28 -RRB- , a novel binding partner of DOCK180 , promotes cell migration by regulating focal adhesion formation .
9808620	0	DOCK180	49,56	Rac1	14,18	DOCK180	Rac1	1793	5879	Gene	Gene	protein|appos|START_ENTITY Activation|nmod|protein Activation|nmod|END_ENTITY	Activation of Rac1 by a Crk SH3-binding protein , DOCK180 .
18596235	0	DOCK180	19,26	SNX5	36,40	DOCK180	SNX5	1793	27131	Gene	Gene	domain|nmod|START_ENTITY binds|nsubj|domain binds|nmod|END_ENTITY	The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose_6-phosphate receptor transport .
18725541	0	DOCK180	75,82	uPAR	0,4	DOCK180	uPAR	1793	5329	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180 .
12191913	0	DOCK2	16,21	CDM	4,7	DOCK2	CDM	1794	800	Gene	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The CDM protein DOCK2 in lymphocyte migration .
12393632	0	DOCK2	0,5	CrkL	22,26	DOCK2	CrkL	1794	1399	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines .
12176041	0	DOCK2	0,5	Rac2	53,57	DOCK2	Rac2	1794	5880	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription .
25976676	0	DOCK6	38,43	dedicator_of_cytokinesis_6	10,36	DOCK6	dedicator of cytokinesis 6	508023(Tax:9913)	508023(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect in dedicator_of_cytokinesis_6 -LRB- DOCK6 -RRB- on steroid production in theca cells of follicular_cysts .
22842144	0	DOCK7	0,5	TACC3	21,26	DOCK7	TACC3	67299(Tax:10090)	21335(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis .
22461490	0	DOCK8	0,5	Cdc42	11,16	DOCK8	Cdc42	81704	998	Gene	Gene	activator|nsubj|START_ENTITY activator|amod|END_ENTITY	DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses .
19481264	0	DOK-1	30,35	CD45	0,4	DOK-1	CD45	1796	5788	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells .
15546884	0	DOK1	0,4	SHP-2	14,19	DOK1	SHP-2	1796	5781	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like_growth_factor_I signaling in cultured vascular smooth muscle cells .
22280843	0	DOP-2	53,58	GPA-14	85,91	DOP-2	GPA-14	179347(Tax:6239)	172269(Tax:6239)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Caenorhabditis_elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14 , a Gai subunit .
26924680	0	DOPA_Decarboxylase	24,42	DDC	44,47	DOPA Decarboxylase	DDC	1644	1644	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Common Variation in the DOPA_Decarboxylase -LRB- DDC -RRB- Gene and Human Striatal DDC Activity In Vivo .
15879433	0	DOPA_decarboxylase	56,74	DDC	76,79	DOPA decarboxylase	DDC	1644	1644	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Haplotype analysis indicates an association between the DOPA_decarboxylase -LRB- DDC -RRB- gene and nicotine_dependence .
12559959	0	DOPAchrome_tautomerase	29,51	OTX2	0,4	DOPAchrome tautomerase	OTX2	1638	5015	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	OTX2 regulates expression of DOPAchrome_tautomerase in human retinal_pigment_epithelium .
10886507	0	DOPAchrome_tautomerase	96,118	tyrosinase-related_protein-2	67,95	DOPAchrome tautomerase	tyrosinase-related protein-2	1638	1638	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Human melanocytes and melanomas express novel mRNA isoforms of the tyrosinase-related_protein-2 / DOPAchrome_tautomerase gene : molecular and functional characterization .
11004520	0	DOPAchrome_tautomerase	81,103	tyrosinase-related_protein_2	52,80	DOPAchrome tautomerase	tyrosinase-related protein 2	1638	1638	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Identification of a composite enhancer of the human tyrosinase-related_protein_2 / DOPAchrome_tautomerase gene .
11180971	0	DOPAchrome_tautomerase	43,65	tyrosinase-related_protein_2	14,42	DOPAchrome tautomerase	tyrosinase-related protein 2	1638	1638	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of tyrosinase-related_protein_2 / DOPAchrome_tautomerase in the retinoblastoma .
19953128	0	DOPAchrome_tautomerase	109,131	tyrosinase-related_protein_2	78,106	DOPAchrome tautomerase	tyrosinase-related protein 2	100170232(Tax:9940)	100170232(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Molecular cloning , sequence characteristics , and polymorphism analyses of the tyrosinase-related_protein_2 / DOPAchrome_tautomerase gene of black-boned sheep -LRB- Ovis_aries -RRB- .
18830673	0	DORNROSCHEN	124,135	BIM1	0,4	DORNROSCHEN	BIM1	837856(Tax:3702)	830708(Tax:3702)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	BIM1 , a bHLH protein involved in brassinosteroid signalling , controls Arabidopsis embryonic patterning via interaction with DORNROSCHEN and DORNROSCHEN-LIKE .
19369397	0	DORNROSCHEN	0,11	MONOPTEROS	60,70	DORNROSCHEN	MONOPTEROS	837856(Tax:3702)	838573(Tax:3702)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	DORNROSCHEN is a direct target of the auxin response factor MONOPTEROS in the Arabidopsis embryo .
17682829	0	DORNROSCHEN-LIKE	0,16	AP2	21,24	DORNROSCHEN-LIKE	AP2	839073;837856	829845(Tax:3702)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	DORNROSCHEN-LIKE , an AP2 gene , is necessary for stamen emergence in Arabidopsis .
21289070	0	DOT1L	0,5	dystrophin	16,26	DOT1L	dystrophin	84444	1756	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	DOT1L regulates dystrophin expression and is critical for cardiac function .
25480962	0	DOXA-1	17,23	TSP-15	10,16	DOXA-1	TSP-15	182313(Tax:6239)	192065(Tax:6239)	Gene	Gene	Complex|compound|START_ENTITY Complex|compound|END_ENTITY	The BLI-3 / TSP-15 / DOXA-1 Dual Oxidase Complex Is Required for Iodide Toxicity in Caenorhabditis_elegans .
8524253	0	DP-1	6,10	E2F-1	0,5	DP-1	E2F-1	7027	1869	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|appos|induces	E2F-1 : DP-1 induces p53 and overrides survival factors to trigger apoptosis .
18687693	0	DP-1	98,102	SOCS-3	0,6	DP-1	SOCS-3	7027	9021	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	SOCS-3 inhibits E2F/DP -1 transcriptional activity and cell cycle progression via interaction with DP-1 .
7813562	0	DP-1904	0,7	ICAM-1	80,86	DP-1904	ICAM-1	2944390(Tax:177439)	3383	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	DP-1904 , a specific inhibitor of thromboxane_A2 synthesizing enzyme , suppresses ICAM-1 expression by stimulated vascular endothelial cells .
16153597	0	DP103	44,49	FOXL2	23,28	DP103	FOXL2	11218	668	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis .
18318469	0	DP2	78,81	CRTH2	71,76	DP2	CRTH2	11251	11251	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of a new class of potent , selective , and orally bioavailable CRTH2 -LRB- DP2 -RRB- receptor antagonists for the treatment of allergic inflammatory diseases .
21916510	0	DP2	89,92	CRTH2	82,87	DP2	CRTH2	11251	11251	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Discovery of potent , selective , and orally bioavailable alkynylphenoxyacetic_acid CRTH2 -LRB- DP2 -RRB- receptor antagonists for the treatment of allergic inflammatory diseases .
24900284	0	DP2	38,41	CRTH2	31,36	DP2	CRTH2	11251	11251	Gene	Gene	Receptor|appos|START_ENTITY Receptor|compound|END_ENTITY	Discovery of a Novel Series of CRTH2 -LRB- DP2 -RRB- Receptor Antagonists Devoid of Carboxylic_Acids .
24900359	0	DP2	72,75	CRTH2	65,70	DP2	CRTH2	11251	11251	Gene	Gene	Receptor|appos|START_ENTITY Receptor|compound|END_ENTITY	Optimization of the Central Core of Indolinone-Acetic_Acid-Based CRTH2 -LRB- DP2 -RRB- Receptor Antagonists .
25517972	0	DP2	26,29	CRTh2	31,36	DP2	CRTh2	11251	11251	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Correction : Expression of DP2 -LRB- CRTh2 -RRB- , a Prostaglandin D2 Receptor , in Human Mast Cells .
18805447	0	DP4	101,104	dipeptidyl_peptidase_4	77,99	DP4	dipeptidyl peptidase 4	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The anti-inflammatory effect of neuropeptide_Y -LRB- NPY -RRB- in rats is dependent on dipeptidyl_peptidase_4 -LRB- DP4 -RRB- activity and age .
16243436	0	DP5	49,52	Bax	113,116	DP5	Bax	117271(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY dimmers|dep|expression dimmers|amod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16243436	0	DP5	49,52	Bax	98,101	DP5	Bax	117271(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
17485271	0	DP58	0,4	neuronal_nuclei	74,89	DP58	neuronal nuclei	218440(Tax:10090)	52897(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	DP58 , an inducible myeloid protein , is constitutively expressed in murine neuronal_nuclei .
17900288	0	DPB1	54,58	DQA1	42,46	DPB1	DQA1	3115	3117	Gene	Gene	DRB1|dep|START_ENTITY DRB1|dep|END_ENTITY	HLA class I -LRB- A , B , C -RRB- and class II -LRB- DRB1 , DQA1 , DQB1 , DPB1 -RRB- alleles and haplotypes in the Han from southern China .
10689123	0	DPB1	25,29	DQB1	19,23	DPB1	DQB1	3115	3119	Gene	Gene	START_ENTITY|nsubj|DRB1 DRB1|appos|END_ENTITY	HLA class II DRB1 , DQB1 , DPB1 polymorphism and cardiomyopathy due to Trypanosoma_cruzi_chronic_infection .
9285566	0	DPC4	35,39	Smad4	41,46	DPC4	Smad4	4089	4089	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Comparative mutational analysis of DPC4 -LRB- Smad4 -RRB- in prostatic and colorectal_carcinomas .
9838102	0	DPC4	47,51	Smad4	40,45	DPC4	Smad4	4089	4089	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Analysis of 5 ' - flanking region of human Smad4 -LRB- DPC4 -RRB- gene .
12775023	0	DPD	33,36	Dihydropyrimidine_dehydrogenase	0,31	DPD	Dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in gastric_cancer tissue and effect of DPD inhibitory fluoropyrimidines .
12775023	0	DPD	86,89	Dihydropyrimidine_dehydrogenase	0,31	DPD	Dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in gastric_cancer tissue and effect of DPD inhibitory fluoropyrimidines .
15737843	0	DPD	22,25	ERCC1	27,32	DPD	ERCC1	1806	2067	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Downregulation of TS , DPD , ERCC1 , GST-Pi , EGFR , and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal_cancer .
10925685	0	DPD	80,83	dihydropyrimidine_dehydrogenase	47,78	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Significance of thymidylate_synthase -LRB- TS -RRB- and dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in breast_cancer tissue -RSB- .
11290431	0	DPD	53,56	dihydropyrimidine_dehydrogenase	20,51	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The significance of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in bladder_cancer .
11555601	0	DPD	78,81	dihydropyrimidine_dehydrogenase	45,76	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prevalence of a common point mutation in the dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- gene within the 5 ' - splice donor site of intron 14 in patients with severe 5-fluorouracil -LRB- 5-FU -RRB- - related toxicity compared with controls .
12617910	0	DPD	88,91	dihydropyrimidine_dehydrogenase	55,86	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Design and synthesis of the tumor-activated prodrug of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- inhibitor , RO0094889 for combination therapy with capecitabine .
12851836	0	DPD	58,61	dihydropyrimidine_dehydrogenase	25,56	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Clinical implications of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in 5-FU-based chemotherapy : mutations in the DPD gene , and DPD inhibitory fluoropyrimidines .
12852985	0	DPD	58,61	dihydropyrimidine_dehydrogenase	25,56	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Circadian variations of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in oral mucosa of healthy volunteers -RSB- .
15271097	0	DPD	197,200	dihydropyrimidine_dehydrogenase	164,195	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	A simple and rapid high-performance liquid chromatographic -LRB- HPLC -RRB- method for 5-fluorouracil -LRB- 5-FU -RRB- assay in plasma and possible detection of patients with impaired dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity .
15566669	0	DPD	54,57	dihydropyrimidine_dehydrogenase	22,53	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Relationship between dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity and toxicity of 5-FU-based adjuvant chemotherapy in colorectal_cancer patients -RSB- .
15604991	0	DPD	109,112	dihydropyrimidine_dehydrogenase	76,107	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Evaluation of sensitivity to 5-FU on the basis of thymidylate_synthase -LRB- TS -RRB- / dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity and chromosomal analysis in micro tissue specimens of breast_cancer .
15616154	0	DPD	125,128	dihydropyrimidine_dehydrogenase	92,123	DPD	dihydropyrimidine dehydrogenase	479935(Tax:9615)	479935(Tax:9615)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Relationships among plasma -LSB- 2 - -LRB- 13 -RRB- C -RSB- uracil concentrations , breath -LRB- 13 -RRB- CO -LRB- 2 -RRB- expiration , and dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in the liver in normal and dpd-deficient dogs .
19628084	0	DPD	67,70	dihydropyrimidine_dehydrogenase	34,65	DPD	dihydropyrimidine dehydrogenase	81656(Tax:10116)	81656(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Circadian variation in intestinal dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- expression : a potential mechanism for benefits of 5FU chrono-chemotherapy .
21353513	0	DPD	111,114	dihydropyrimidine_dehydrogenase	78,109	DPD	dihydropyrimidine dehydrogenase	99586(Tax:10090)	99586(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- protein expression .
9323539	0	DPD	80,83	dihydropyrimidine_dehydrogenase	47,78	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Semi-automated radioassay for determination of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity .
9830621	0	DPD	45,48	dihydropyrimidine_dehydrogenase	12,43	DPD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- modulation in 5-FU pharmacology .
1544318	0	DPEP1	48,53	renal_dipeptidase	24,41	DPEP1	renal dipeptidase	1800	1800	Gene	Gene	Assignment|appos|START_ENTITY Assignment|nmod|gene gene|compound|END_ENTITY	Assignment of the human renal_dipeptidase gene -LRB- DPEP1 -RRB- to band q24 of chromosome 16 .
9782084	0	DPH2L2	82,88	diphthamide_biosynthesis-like_protein-2	36,75	DPH2L2	diphthamide biosynthesis-like protein-2	1802	1802	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and localization of a human diphthamide_biosynthesis-like_protein-2 gene , DPH2L2 .
11868902	0	DPOSH	61,66	plenty_of_SH3s	45,59	DPOSH	plenty of SH3s	36990(Tax:7227)	36990(Tax:7227)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Neural-specific overexpression of drosophila plenty_of_SH3s -LRB- DPOSH -RRB- extends the longevity of adult flies .
26010513	0	DPP-4	0,5	AMPK	85,89	DPP-4	AMPK	1803	5564	Gene	Gene	Cytotoxicity|compound|START_ENTITY Cytotoxicity|nmod|END_ENTITY	DPP-4 Inhibitor Linagliptin Attenuates Ab-induced Cytotoxicity through Activation of AMPK in Neuronal Cells .
22284242	0	DPP-4	24,29	Dipeptidyl_peptidase-4	0,22	DPP-4	Dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors are favourable to glucagon-like_peptide-1 -LRB- GLP-1 -RRB- agonists : no .
22284241	0	DPP-4	23,28	Dipeptidylpeptidase-4	0,21	DPP-4	Dipeptidylpeptidase-4	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Dipeptidylpeptidase-4 -LRB- DPP-4 -RRB- inhibitors are favourable to glucagon-like_peptide-1 -LRB- GLP-1 -RRB- _ receptor agonists : yes .
25473177	0	DPP-4	21,26	MK-0626	0,7	DPP-4	MK-0626	13482(Tax:10090)	1476727(Tax:190192)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	MK-0626 , a selective DPP-4 inhibitor , attenuates hepatic_steatosis in ob/ob mice .
21595280	0	DPP-4	73,78	dipeptidyl_peptidase-4	49,71	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	-LSB- Severe hypoglycemia by combination therapy with dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors and sulfonylureas -RSB- .
21613229	0	DPP-4	46,51	dipeptidyl_peptidase-4	22,44	DPP-4	dipeptidyl peptidase-4	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Protective effects of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor against increased b cell apoptosis induced by dietary sucrose and linoleic_acid in mice with diabetes .
22162539	0	DPP-4	71,76	dipeptidyl_peptidase-4	47,69	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Quantitative model of the relationship between dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibition and response : meta-analysis of alogliptin , saxagliptin , sitagliptin , and vildagliptin efficacy results .
24531198	0	DPP-4	94,99	dipeptidyl_peptidase-4	70,92	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors .
24614606	0	DPP-4	53,58	dipeptidyl_peptidase-4	29,51	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Comparative effectiveness of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors and human glucagon-like_peptide-1 -LRB- GLP-1 -RRB- analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region : a systematic review .
24622716	0	DPP-4	53,58	dipeptidyl_peptidase-4	29,51	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	SYR-472 , a novel once-weekly dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor , in type_2_diabetes_mellitus : a phase 2 , randomised , double-blind , placebo-controlled trial .
24829965	0	DPP-4	38,43	dipeptidyl_peptidase-4	14,36	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	The safety of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors or sodium-glucose_cotransporter_2 -LRB- SGLT-2 -RRB- inhibitors added to metformin background therapy in patients with type_2_diabetes_mellitus : a systematic review and meta-analysis .
24993124	0	DPP-4	54,59	dipeptidyl_peptidase-4	30,52	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Alogliptin ; a review of a new dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor for the treatment of type_2_diabetes_mellitus .
25169215	0	DPP-4	118,123	dipeptidyl_peptidase-4	94,116	DPP-4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Plants Fagonia cretica L. and Hedera_nepalensis K. Koch contain natural compounds with potent dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitory activity .
27040669	0	DPP-4	35,40	dipeptidyl_peptidase-4	11,33	DPP-4	dipeptidyl peptidase-4	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Effects of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibition on angiogenesis and hypoxic_injury_in_type_2_diabetes .
21755761	0	DPP-4	42,47	dipeptidyl_peptidase-IV	17,40	DPP-4	dipeptidyl peptidase-IV	1803	1803	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Emerging role of dipeptidyl_peptidase-IV -LRB- DPP-4 -RRB- inhibitor vildagliptin in the management of type 2 diabetes .
26048211	0	DPP-4	88,93	dipeptidyl_peptidase_4	64,86	DPP-4	dipeptidyl peptidase 4	1803	1803	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Hospitalisation for heart_failure and mortality associated with dipeptidyl_peptidase_4 -LRB- DPP-4 -RRB- inhibitor use in an unselected population of subjects with type 2 diabetes : a nested case-control study .
26611248	0	DPP-4	89,94	dipeptidyl_peptidase_4	65,87	DPP-4	dipeptidyl peptidase 4	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Lessons learned from cardiovascular outcome clinical trials with dipeptidyl_peptidase_4 -LRB- DPP-4 -RRB- inhibitors .
17827003	0	DPP-4	141,146	dipeptidyl_peptidase_IV	116,139	DPP-4	dipeptidyl peptidase IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Design , synthesis , and biological evaluation of triazolopiperazine-based beta-amino_amides as potent , orally active dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitors .
21218817	0	DPP-4	123,128	dipeptidyl_peptidase_IV	98,121	DPP-4	dipeptidyl peptidase IV	1803	1803	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Discovery of a 3-pyridylacetic_acid derivative -LRB- TAK-100 -RRB- as a potent , selective and orally active dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitor .
22938786	0	DPP-4	99,104	dipeptidyl_peptidase_IV	74,97	DPP-4	dipeptidyl peptidase IV	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of 3H-imidazo -LSB- 4,5-c -RSB- quinolin-4 -LRB- 5H -RRB- - ones as potent and selective dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitors .
25596166	0	DPP-4	99,104	dipeptidyl_peptidase_IV	74,97	DPP-4	dipeptidyl peptidase IV	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of 3H-imidazo -LSB- 4,5-c -RSB- quinolin-4 -LRB- 5H -RRB- - ones as potent and selective dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitors : Use of a carboxylate prodrug to improve bioavailability .
19538242	0	DPP-4	72,77	dipeptidylpeptidase-4	49,70	DPP-4	dipeptidylpeptidase-4	1803	1803	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Investigation of the effect of oral metformin on dipeptidylpeptidase-4 -LRB- DPP-4 -RRB- activity in Type 2 diabetes .
25406260	0	DPP-IV	82,88	CD26	89,93	DPP-IV	CD26	1803	1803	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	High Fat Meal Leads to Decreased Insulinogenesis _ Incretin levels With Increased DPP-IV , CD26 Expression _ Glucagon levels versus a High fruit and Fiber Meal .
21245057	0	DPP-IV	25,31	Parathyroid_hormone	0,19	DPP-IV	Parathyroid hormone	13482(Tax:10090)	19226(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nsubj|END_ENTITY	Parathyroid_hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4 -LRB- + -RRB- stem cells into the ischaemic heart .
16106524	0	DPP-IV	132,138	dipeptidyl_peptidase-IV	107,130	DPP-IV	dipeptidyl peptidase-IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	KR-62436 , 6 - -LCB- 2 - -LSB- 2 - -LRB- 5-cyano-4 ,5 - dihydropyrazol-1-yl -RRB- -2 - oxoethylamino -RSB- ethylamino -RCB- nicotinonitrile , is a novel dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor with anti-hyperglycemic activity .
18068977	0	DPP-IV	39,45	dipeptidyl_peptidase-IV	14,37	DPP-IV	dipeptidyl peptidase-IV	1803	1803	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- by atorvastatin .
20082866	0	DPP-IV	35,41	dipeptidyl_peptidase-IV	10,33	DPP-IV	dipeptidyl peptidase-IV	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor -LRB- Vildagliptin -RRB- on peripheral nerves in streptozotocin-induced diabetic rats .
20213998	0	DPP-IV	52,58	dipeptidyl_peptidase-IV	27,50	DPP-IV	dipeptidyl peptidase-IV	1803	1803	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- in Indian type-2 diabetic population .
26592960	0	DPP-IV	39,45	dipeptidyl_peptidase-IV	14,37	DPP-IV	dipeptidyl peptidase-IV	1803	1803	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Monitoring of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- activity in patients with mucopolysaccharidoses types I and II on enzyme replacement therapy - Results of a pilot study .
15002062	0	DPP-IV	78,84	dipeptidyl_peptidase_IV	53,76	DPP-IV	glucagon-like Peptide 1	1803	2641	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Glucagon-like_peptide_1 -LRB- GLP-1 -RRB- secretion and plasma dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- activity in morbidly obese patients undergoing biliopancreatic diversion .
19162567	0	DPP-IV	187,193	dipeptidyl_peptidase_IV	162,185	DPP-IV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Remediation of undesirable secondary interactions encountered in hydrophilic interaction chromatography during development of a quantitative LC-MS/MS assay for a dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitor in monkey serum .
24193022	0	DPP-IV	39,45	dipeptidyl_peptidase_IV	14,37	DPP-IV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- by tryptophan containing dipeptides .
24793774	0	DPP-IV	107,113	dipeptidyl_peptidase_IV	82,105	DPP-IV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	In silico approaches to predict the potential of milk protein-derived peptides as dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitors .
25838146	0	DPP-IV	194,200	dipeptidyl_peptidase_IV	169,192	DPP-IV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and potent inhibitory activities of carboxybenzyl-substituted_8 - -LRB- 3 - -LRB- R -RRB- - aminopiperidin-1-yl -RRB- -7 - -LRB- 2-chloro/cyanobenzyl -RRB- -3 - methyl-3 ,7 - dihydro-purine-2 ,6 - diones as dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitors .
21088147	0	DPP1	97,101	dipeptidyl_peptidase_1	73,95	DPP1	dipeptidyl peptidase 1	1075	1075	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Development and validation of a simple cell-based fluorescence assay for dipeptidyl_peptidase_1 -LRB- DPP1 -RRB- activity .
7974009	0	DPP4	25,29	CD26	37,41	DPP4	CD26	1803	1803	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Regional localization of DPP4 -LRB- alias CD26 and ADCP2 -RRB- to chromosome 2q24 .
26291537	0	DPP4	46,50	Dipeptidyl_Peptidase-4	22,44	DPP4	Dipeptidyl Peptidase-4	281122(Tax:9913)	281122(Tax:9913)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of Inhibiting Dipeptidyl_Peptidase-4 -LRB- DPP4 -RRB- in Cows with Subclinical Ketosis .
26291537	0	DPP4	46,50	Dipeptidyl_Peptidase-4	22,44	DPP4	Dipeptidyl Peptidase-4	281122(Tax:9913)	281122(Tax:9913)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of Inhibiting Dipeptidyl_Peptidase-4 -LRB- DPP4 -RRB- in Cows with Subclinical Ketosis .
21672052	0	DPP4	25,29	Dipeptidyl_peptidase_IV	0,23	DPP4	Dipeptidyl peptidase IV	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- DPP4 -RRB- deficiency increases Th1-driven allergic contact dermatitis .
26051627	0	DPP4	23,27	Dipeptidylpeptidase_4	0,21	DPP4	Dipeptidylpeptidase 4	1803	1803	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dipeptidylpeptidase_4 -LRB- DPP4 , CD26 -RRB- activity in the blood serum of term and preterm neonates with cerebral_ischemia .
26873580	0	DPP4	120,124	dipeptidyl_peptidase-4	96,118	DPP4	dipeptidyl peptidase-4	1803	1803	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A concise review of the bioanalytical methods for the quantitation of sitagliptin , an important dipeptidyl_peptidase-4 -LRB- DPP4 -RRB- inhibitor , utilized for the pharmacokinetic characterization of the drug .
26671446	0	DPP4	63,67	dipeptidyl_peptidase_4	39,61	DPP4	dipeptidyl peptidase 4	1803	1803	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Unravelling the immunological roles of dipeptidyl_peptidase_4 -LRB- DPP4 -RRB- activity and/or structure homolog -LRB- DASH -RRB- proteins .
26983599	0	DPP4	42,46	dipeptidyl_peptidase_4	18,40	DPP4	dipeptidyl peptidase 4	1803	1803	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Metabolic role of dipeptidyl_peptidase_4 -LRB- DPP4 -RRB- in primary human -LRB- pre -RRB- adipocytes .
17276063	0	DPP4	133,137	dipeptidyl_peptidase_IV	108,131	DPP4	dipeptidyl peptidase IV	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Pyrrolidine-constrained phenethylamines : The design of potent , selective , and pharmacologically efficacious dipeptidyl_peptidase_IV -LRB- DPP4 -RRB- inhibitors from a lead-like screening hit .
7903569	0	DPP4	42,46	dipeptidylpeptidase_IV	18,40	DPP4	dipeptidylpeptidase IV	397492(Tax:9823)	397492(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the dipeptidylpeptidase_IV -LRB- DPP4 -RRB- gene to pig chromosome 15q21 .
16110352	0	DPP8	46,50	dipeptidyl_peptidase_8	22,44	DPP8	dipeptidyl peptidase 8	54878	54878	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Expression of a novel dipeptidyl_peptidase_8 -LRB- DPP8 -RRB- transcript variant , DPP8-v3 , in human testis .
19407151	0	DPPI	0,4	KLK4	18,22	DPPI	KLK4	13032(Tax:10090)	56640(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	DPPI may activate KLK4 during enamel formation .
15168326	0	DPPIV	25,30	Dipeptidyl_peptidase_IV	0,23	DPPIV	Dipeptidyl peptidase IV	100341424(Tax:9986)	100341424(Tax:9986)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- DPPIV -RRB- activity in the tear fluid as an indicator of the severity of corneal_injury : a histochemical and biochemical study .
17204353	0	DPPIV	43,48	dipeptidyl_peptidase_IV	18,41	DPPIV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Serum activity of dipeptidyl_peptidase_IV -LRB- DPPIV ; EC 3.4.14.5 -RRB- in breast-fed infants with symptoms of allergy .
12713798	0	DPP_IV	0,6	GIP	145,148	DPP IV	GIP	1803	2695	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nsubj|resistance	DPP_IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent_insulinotropic_polypeptide , -LRB- Ser2-Asp13 -RRB- GIP .
10103156	0	DPP_IV	41,47	dipeptidyl_peptidase_IV	16,39	DPP IV	dipeptidyl peptidase IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Development of dipeptidyl_peptidase_IV -LRB- DPP_IV -RRB- activity in postnatal differentiation of the submandibular gland in mice -RSB- .
19640223	0	DPP_IV	39,45	dipeptidyl_peptidase_IV	14,37	DPP IV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DPP_IV -RRB- is one of the mechanisms explaining the hypoglycemic effect of berberine .
12657250	0	DPP_IV	119,125	dipeptidylpeptidase_IV	95,117	DPP IV	dipeptidylpeptidase IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	The expression of T-cell surface antigens CTLA-4 , CD26 , and CD28 is modulated by inhibition of dipeptidylpeptidase_IV -LRB- DPP_IV , CD26 -RRB- activity in murine stress-induced abortions .
23603345	0	DPYD	38,42	Dihydropyrimidine_dehydrogenase	0,31	DPYD	Dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase gene -LRB- DPYD -RRB- polymorphism among Caucasian and non-Caucasian patients with 5-FU - and capecitabine-related toxicity using full sequencing of DPYD .
16806531	0	DPYD	44,48	Sp1	12,15	DPYD	Sp1	1806	6667	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of Sp1 and Sp3 in the constitutive DPYD gene expression .
19288105	0	DPYD	76,80	dihydropyrimidine_dehydrogenase	43,74	DPYD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of large intragenic rearrangements in dihydropyrimidine_dehydrogenase -LRB- DPYD -RRB- gene in fluoropyrimidine-treated patients with high-grade toxicity .
25117664	0	DPYD	54,58	dihydropyrimidine_dehydrogenase	21,52	DPYD	dihydropyrimidine dehydrogenase	1806	1806	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in dihydropyrimidine_dehydrogenase -LRB- DPYD -RRB- gene in a healthy adult Indian population .
26771602	0	DPYS	102,106	Dihydropyrimidinase	81,100	DPYS	Dihydropyrimidinase	1807	1807	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c. 1443 +5 G > A in the Dihydropyrimidinase -LRB- DPYS -RRB- Gene .
16321170	0	DPYSL2	52,58	dihydropyrimidinase-like_2	24,50	DPYSL2	dihydropyrimidinase-like 2	1808	1808	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An investigation of the dihydropyrimidinase-like_2 -LRB- DPYSL2 -RRB- gene in schizophrenia : genetic association study and expression analysis .
23568759	0	DPYSL3	57,63	CRMP4	65,70	DPYSL3	CRMP4	1809	1809	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A rare motor neuron deleterious missense mutation in the DPYSL3 -LRB- CRMP4 -RRB- gene is associated with ALS .
10849736	0	DP_IV	92,97	CD26	98,102	DP IV	CD26	1803	1803	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	A new type of fluorogenic substrates for determination of cellular dipeptidyl_peptidase_IV -LRB- DP_IV / CD26 -RRB- activity .
7910536	0	DP_IV	25,30	Dipeptidyl_peptidase_IV	0,23	DP IV	Dipeptidyl peptidase IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- DP_IV -RRB- activity in serum and on lymphocytes of MRL/Mp-lpr/lpr mice correlates with disease onset .
10849736	0	DP_IV	92,97	dipeptidyl_peptidase_IV	67,90	DP IV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	A new type of fluorogenic substrates for determination of cellular dipeptidyl_peptidase_IV -LRB- DP_IV / CD26 -RRB- activity .
11309152	0	DP_IV	39,44	dipeptidyl_peptidase_IV	14,37	DP IV	dipeptidyl peptidase IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DP_IV , CD26 -RRB- activity abrogates stress-induced , cytokine-mediated murine abortions .
2871821	0	DP_IV	57,62	dipeptidyl_peptidase_IV	32,55	DP IV	dipeptidyl peptidase IV	1803	1803	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	-LSB- Diagnostic value of the enzyme dipeptidyl_peptidase_IV -LRB- DP_IV -RRB- in abdominal_cancers -RSB- .
9436466	0	DP_IV	39,44	dipeptidyl_peptidase_IV	14,37	DP IV	dipeptidyl peptidase IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|nmod|END_ENTITY	Inhibitors of dipeptidyl_peptidase_IV -LRB- DP_IV , CD26 -RRB- induces secretion of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- in stimulated mouse splenocytes and thymocytes .
17900288	0	DQA1	42,46	DPB1	54,58	DQA1	DPB1	3117	3115	Gene	Gene	DRB1|dep|START_ENTITY DRB1|dep|END_ENTITY	HLA class I -LRB- A , B , C -RRB- and class II -LRB- DRB1 , DQA1 , DQB1 , DPB1 -RRB- alleles and haplotypes in the Han from southern China .
23039102	0	DQA1	48,52	DQA1	60,64	DQA1	DQA1	3117	3117	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Identification of three novel HLA-DQA1 alleles : DQA1 * 01:08 , DQA1 * 01:09 and DQA1 * 03:03:02 .
23039102	0	DQA1	60,64	DQA1	48,52	DQA1	DQA1	3117	3117	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Identification of three novel HLA-DQA1 alleles : DQA1 * 01:08 , DQA1 * 01:09 and DQA1 * 03:03:02 .
10718431	0	DQA1	11,15	DQB1	22,26	DQA1	DQB1	3117	3119	Gene	Gene	HLA-DRB1|dep|START_ENTITY END_ENTITY|compound|HLA-DRB1	HLA-DRB1 , - DQA1 , and - DQB1 genotypes in patients with nasal_polyposis .
11920855	0	DQA1	75,79	DQB1	82,86	DQA1	DQB1	3117	3119	Gene	Gene	HLA_A|nummod|START_ENTITY disequilibrium|nmod|HLA_A disequilibrium|appos|END_ENTITY	Investigation of linkage and association/linkage disequilibrium of HLA_A - , DQA1 - , DQB1 - , and DRB1-alleles in 69 sib-pair - and 89 trio-families with schizophrenia .
12144622	0	DQA1	32,36	DQB1	38,42	DQA1	DQB1	3117	3119	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|appos|END_ENTITY	Molecular analysis of HLA-DRB1 , DQA1 , DQB1 , DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico .
15305487	0	DQA1	28,32	DQB1	34,38	DQA1	DQB1	3117	3119	Gene	Gene	alleles|dep|START_ENTITY alleles|dep|END_ENTITY	The association of HLA-DRB , DQA1 , DQB1 alleles and haplotype frequency in Iranian patients with pulmonary_tuberculosis .
15789899	0	DQA1	6,10	DQB1	12,16	DQA1	DQB1	3117	3119	Gene	Gene	DRB1|appos|START_ENTITY END_ENTITY|nsubj|DRB1	DRB1 , DQA1 , DQB1 genes in Turkish children with rheumatic_fever .
1679052	0	DQA1	63,67	DQB1	69,73	DQA1	DQB1	3117	3119	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular analysis of the role of the HLA class II genes DRB1 , DQA1 , DQB1 , and DPB1 in susceptibility to Lyme_arthritis .
17714903	0	DQA1	22,26	DQB1	28,32	DQA1	DQB1	3117	3119	Gene	Gene	HLA-DRB1|nummod|START_ENTITY HLA-DRB1|nummod|END_ENTITY	Analysis of HLA-DRB1 , DQA1 , DQB1 haplotypes in Sardinian centenarians .
17900288	0	DQA1	42,46	DQB1	48,52	DQA1	DQB1	3117	3119	Gene	Gene	DRB1|dep|START_ENTITY DRB1|dep|DPB1 DPB1|compound|END_ENTITY	HLA class I -LRB- A , B , C -RRB- and class II -LRB- DRB1 , DQA1 , DQB1 , DPB1 -RRB- alleles and haplotypes in the Han from southern China .
22362761	0	DQA1	62,66	DQB1	73,77	DQA1	DQB1	3117	3119	Gene	Gene	START_ENTITY|dep|02:01 02:01|compound|END_ENTITY	Structural and functional studies of trans-encoded HLA-DQ2 .3 -LRB- DQA1 * 03:01 / DQB1 * 02:01 -RRB- protein molecule .
26671138	0	DQA1	35,39	DQB1	41,45	DQA1	DQB1	3117	3119	Gene	Gene	DRB1|dep|START_ENTITY DRB1|dep|END_ENTITY	Association of HLA class II -LRB- DRB1 , DQA1 , DQB1 -RRB- alleles and haplotypes with myasthenia_gravis and its subgroups in the Iranian population .
26822082	0	DQA1	19,23	DQB1	30,34	DQA1	DQB1	3117	3119	Gene	Gene	HLA-DRB1|ccomp|START_ENTITY HLA-DRB1|dep|END_ENTITY	The HLA-DRB1 * 15:01 - DQA1 * 01:02 - DQB1 * 06:02 haplotype protects autoantibody-positive relatives from type_1_diabetes throughout the stages of disease progression .
8226139	0	DQA1	31,35	DQB1	37,41	DQA1	DQB1	3117	3119	Gene	Gene	associated|advmod|START_ENTITY associated|nsubjpass|haplotypes haplotypes|compound|END_ENTITY	Combinations of specific DRB1 , DQA1 , DQB1 haplotypes are associated with insulin-dependent_diabetes_mellitus in Sardinia .
8590546	0	DQA1	33,37	DQB1	27,31	DQA1	DQB1	3117	3119	Gene	Gene	alleles|nummod|START_ENTITY Distribution|dep|alleles Distribution|nmod|HLA-DPB1 HLA-DPB1|appos|END_ENTITY	Distribution of HLA-DPB1 , - DQB1 - DQA1 alleles among Sardinian celiac patients .
8851725	0	DQA1	10,14	DQB1	16,20	DQA1	DQB1	3117	3119	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|appos|END_ENTITY	HLA-DRB1 , DQA1 , DQB1 DNA polymorphism in the Bulgarian population .
15104677	0	DQA1	11,15	DRB1	18,22	DQA1	DRB1	3117	3123	Gene	Gene	HLA-DQB1|appos|START_ENTITY HLA-DQB1|dep|disequilibrium disequilibrium|compound|END_ENTITY	HLA-DQB1 , - DQA1 , - DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara , Mexico .
1679052	0	DQA1	63,67	DRB1	57,61	DQA1	DRB1	3117	3123	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular analysis of the role of the HLA class II genes DRB1 , DQA1 , DQB1 , and DPB1 in susceptibility to Lyme_arthritis .
26762682	0	DQA1	44,48	DRB1	32,36	DQA1	DRB1	3117	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Three new HLA class II alleles : DRB1 * 08:70 , DQA1 * 01:13 and DQA1 * 03:01:03 .
7974465	0	DQA1	4,8	DRB1	35,39	DQA1	DRB1	3117	3125	Gene	Gene	allele|compound|START_ENTITY carried|nsubjpass|allele carried|nmod|1001 1001|compound|END_ENTITY	The DQA1 * 0104 allele is carried by DRB1 * 1001 - and DRB1 * 1401-positive haplotypes in Caucasians , Africans and Orientals .
7974465	0	DQA1	4,8	DRB1	50,54	DQA1	DRB1	3117	3125	Gene	Gene	allele|compound|START_ENTITY carried|nsubjpass|allele carried|nmod|1001 1001|dep|END_ENTITY	The DQA1 * 0104 allele is carried by DRB1 * 1001 - and DRB1 * 1401-positive haplotypes in Caucasians , Africans and Orientals .
8071103	0	DQA1	0,4	DRB1	50,54	DQA1	DRB1	3117	3123	Gene	Gene	alleles|nsubj|START_ENTITY alleles|dep|have have|nmod|END_ENTITY	DQA1 * 03 subtypes have different associations with DRB1 and DQB1 alleles .
8226139	0	DQA1	31,35	DRB1	25,29	DQA1	DRB1	3117	3123	Gene	Gene	associated|advmod|START_ENTITY associated|nsubjpass|Combinations Combinations|nmod|END_ENTITY	Combinations of specific DRB1 , DQA1 , DQB1 haplotypes are associated with insulin-dependent_diabetes_mellitus in Sardinia .
9157087	0	DQA1	26,30	DRB1	101,105	DQA1	DRB1	3117	3123	Gene	Gene	Polymorphism|dep|START_ENTITY Polymorphism|dep|association association|nmod|END_ENTITY	Polymorphism of HLA-DRB , _ - DQA1 , and - DQB1 in rheumatoid_arthritis in Asian Indians : association with DRB1 * 0405 and DRB1 * 1001 .
12144622	0	DQA1	32,36	HLA-DRB1	22,30	DQA1	HLA-DRB1	3117	3123	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Molecular analysis of HLA-DRB1 , DQA1 , DQB1 , DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico .
8851725	0	DQA1	10,14	HLA-DRB1	0,8	DQA1	HLA-DRB1	3117	3123	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	HLA-DRB1 , DQA1 , DQB1 DNA polymorphism in the Bulgarian population .
10689123	0	DQB1	19,23	DPB1	25,29	DQB1	DPB1	3119	3115	Gene	Gene	DRB1|appos|START_ENTITY END_ENTITY|nsubj|DRB1	HLA class II DRB1 , DQB1 , DPB1 polymorphism and cardiomyopathy due to Trypanosoma_cruzi_chronic_infection .
10718431	0	DQB1	22,26	DQA1	11,15	DQB1	DQA1	3119	3117	Gene	Gene	START_ENTITY|compound|HLA-DRB1 HLA-DRB1|dep|END_ENTITY	HLA-DRB1 , - DQA1 , and - DQB1 genotypes in patients with nasal_polyposis .
11920855	0	DQB1	82,86	DQA1	75,79	DQB1	DQA1	3119	3117	Gene	Gene	disequilibrium|appos|START_ENTITY disequilibrium|nmod|HLA_A HLA_A|nummod|END_ENTITY	Investigation of linkage and association/linkage disequilibrium of HLA_A - , DQA1 - , DQB1 - , and DRB1-alleles in 69 sib-pair - and 89 trio-families with schizophrenia .
12144622	0	DQB1	38,42	DQA1	32,36	DQB1	DQA1	3119	3117	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|appos|END_ENTITY	Molecular analysis of HLA-DRB1 , DQA1 , DQB1 , DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico .
15305487	0	DQB1	34,38	DQA1	28,32	DQB1	DQA1	3119	3117	Gene	Gene	alleles|dep|START_ENTITY alleles|dep|END_ENTITY	The association of HLA-DRB , DQA1 , DQB1 alleles and haplotype frequency in Iranian patients with pulmonary_tuberculosis .
15789899	0	DQB1	12,16	DQA1	6,10	DQB1	DQA1	3119	3117	Gene	Gene	START_ENTITY|nsubj|DRB1 DRB1|appos|END_ENTITY	DRB1 , DQA1 , DQB1 genes in Turkish children with rheumatic_fever .
1679052	0	DQB1	69,73	DQA1	63,67	DQB1	DQA1	3119	3117	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular analysis of the role of the HLA class II genes DRB1 , DQA1 , DQB1 , and DPB1 in susceptibility to Lyme_arthritis .
17714903	0	DQB1	28,32	DQA1	22,26	DQB1	DQA1	3119	3117	Gene	Gene	HLA-DRB1|nummod|START_ENTITY HLA-DRB1|nummod|END_ENTITY	Analysis of HLA-DRB1 , DQA1 , DQB1 haplotypes in Sardinian centenarians .
17900288	0	DQB1	48,52	DQA1	42,46	DQB1	DQA1	3119	3117	Gene	Gene	DPB1|compound|START_ENTITY DRB1|dep|DPB1 DRB1|dep|END_ENTITY	HLA class I -LRB- A , B , C -RRB- and class II -LRB- DRB1 , DQA1 , DQB1 , DPB1 -RRB- alleles and haplotypes in the Han from southern China .
22362761	0	DQB1	73,77	DQA1	62,66	DQB1	DQA1	3119	3117	Gene	Gene	02:01|compound|START_ENTITY END_ENTITY|dep|02:01	Structural and functional studies of trans-encoded HLA-DQ2 .3 -LRB- DQA1 * 03:01 / DQB1 * 02:01 -RRB- protein molecule .
26671138	0	DQB1	41,45	DQA1	35,39	DQB1	DQA1	3119	3117	Gene	Gene	DRB1|dep|START_ENTITY DRB1|dep|END_ENTITY	Association of HLA class II -LRB- DRB1 , DQA1 , DQB1 -RRB- alleles and haplotypes with myasthenia_gravis and its subgroups in the Iranian population .
26822082	0	DQB1	30,34	DQA1	19,23	DQB1	DQA1	3119	3117	Gene	Gene	HLA-DRB1|dep|START_ENTITY HLA-DRB1|ccomp|END_ENTITY	The HLA-DRB1 * 15:01 - DQA1 * 01:02 - DQB1 * 06:02 haplotype protects autoantibody-positive relatives from type_1_diabetes throughout the stages of disease progression .
8226139	0	DQB1	37,41	DQA1	31,35	DQB1	DQA1	3119	3117	Gene	Gene	haplotypes|compound|START_ENTITY associated|nsubjpass|haplotypes associated|advmod|END_ENTITY	Combinations of specific DRB1 , DQA1 , DQB1 haplotypes are associated with insulin-dependent_diabetes_mellitus in Sardinia .
8590546	0	DQB1	27,31	DQA1	33,37	DQB1	DQA1	3119	3117	Gene	Gene	HLA-DPB1|appos|START_ENTITY Distribution|nmod|HLA-DPB1 Distribution|dep|alleles alleles|nummod|END_ENTITY	Distribution of HLA-DPB1 , - DQB1 - DQA1 alleles among Sardinian celiac patients .
8851725	0	DQB1	16,20	DQA1	10,14	DQB1	DQA1	3119	3117	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|appos|END_ENTITY	HLA-DRB1 , DQA1 , DQB1 DNA polymorphism in the Bulgarian population .
26206472	0	DQB1	29,33	DQB1	42,46	DQB1	DQB1	3119	3119	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Three new HLA-DQB1 alleles - DQB1 * 03:113 , DQB1 * 06:02:15 and DQB1 * 06:129 .
26206472	0	DQB1	29,33	DQB1	42,46	DQB1	DQB1	3119	3119	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Three new HLA-DQB1 alleles - DQB1 * 03:113 , DQB1 * 06:02:15 and DQB1 * 06:129 .
26206472	0	DQB1	42,46	DQB1	29,33	DQB1	DQB1	3119	3119	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Three new HLA-DQB1 alleles - DQB1 * 03:113 , DQB1 * 06:02:15 and DQB1 * 06:129 .
26206472	0	DQB1	42,46	DQB1	29,33	DQB1	DQB1	3119	3119	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Three new HLA-DQB1 alleles - DQB1 * 03:113 , DQB1 * 06:02:15 and DQB1 * 06:129 .
9095269	5	DQB1	653,657	DQB1	665,669	DQB1	DQB1	3119	3119	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	One atopic -LRB- DRB1 * 0701 , DRB1 * 15 : DRB4 * 0101 , DRB5 * 01 : DQB1 * 0303 , DQB1 * 601/2 -RRB- and one non-atopic -LRB- DRB1 * 0701 , DRB1 * 03011/2 : DRB4 * 01 , DRB3 * 0x : DQB1 * 0303 , DQB1 * 0201/2 -RRB- control were studied .
9095269	5	DQB1	665,669	DQB1	653,657	DQB1	DQB1	3119	3119	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	One atopic -LRB- DRB1 * 0701 , DRB1 * 15 : DRB4 * 0101 , DRB5 * 01 : DQB1 * 0303 , DQB1 * 601/2 -RRB- and one non-atopic -LRB- DRB1 * 0701 , DRB1 * 03011/2 : DRB4 * 01 , DRB3 * 0x : DQB1 * 0303 , DQB1 * 0201/2 -RRB- control were studied .
10674966	0	DQB1	53,57	DRB1	41,45	DQB1	DRB1	3119	3123	Gene	Gene	DQA1|nummod|START_ENTITY END_ENTITY|appos|DQA1	Hardy-Weinberg testing for HLA class II -LRB- DRB1 , DQA1 , DQB1 , and DPB1 -RRB- loci in 26 human ethnic groups .
10931389	0	DQB1	33,37	DRB1	17,21	DQB1	DRB1	3119	3125	Gene	Gene	DPB1|appos|START_ENTITY DPB1|compound|END_ENTITY	HLA-A , _ B , Cw and DRB1 , DRB3/4/5 , DQB1 , DPB1 frequencies in German immunoglobulin A-deficient individuals .
12622908	4	DQB1	885,889	DRB1	872,876	DRB1	DQB1	3123	3119	Gene	Gene	0306|appos|START_ENTITY 0306|appos|0405 0405|compound|END_ENTITY	And the risk to PIH of women with DRB1 * 0306 , DRB1 * 0405 , DQB1 * 0502 were higher than others -LRB- RR : 9.76 , 6.34 , 4.20 -RRB- , and its gene-frequency was higher than controls -LRB- P < 0.01 -RRB- .
1440567	0	DQB1	159,163	DRB1	141,145	DQB1	DRB1	3119	3123	Gene	Gene	homozygotes|dep|START_ENTITY homozygotes|compound|END_ENTITY	Distribution of HLA class II alleles among Scandinavian patients with systemic_lupus_erythematosus -LRB- SLE -RRB- : an increased risk of SLE among non -LSB- DRB1 * 03 , DQA1 * 0501 , DQB1 * 0201 -RSB- class II homozygotes ?
14551034	0	DQB1	19,23	DRB1	13,17	DQB1	DRB1	3119	3123	Gene	Gene	heterogeneity|compound|START_ENTITY HLA-A|appos|heterogeneity HLA-A|appos|END_ENTITY	HLA-A , _ B , _ C , DRB1 , DQB1 matching heterogeneity in ` favourably matched ' kidney recipients .
15853898	0	DQB1	63,67	DRB1	52,56	DQB1	DRB1	3119	3123	Gene	Gene	genes|nummod|START_ENTITY diversity|dep|genes diversity|dep|END_ENTITY	Allelic and haplotypic diversity of HLA-A , - B , - C , - DRB1 , and - DQB1 genes in the Korean population .
15941540	0	DQB1	57,61	DRB1	51,55	DQB1	DRB1	3119	3123	Gene	Gene	locus|nsubj|START_ENTITY locus|advcl|-LSB- -LSB-|dobj|analysis analysis|nmod|END_ENTITY	-LSB- Immunogenetic analysis of human leukocyte antigen DRB1 , DQB1 locus among Han ethnic children with Helicobacter_pylori_infection in Kunming -RSB- .
16320082	0	DQB1	27,31	DRB1	18,22	DQB1	DRB1	3119	3123	Gene	Gene	*|dep|START_ENTITY *|acl:relcl|marks marks|dobj|END_ENTITY	D6S265 * 15 marks a DRB1 * 15 , DQB1 * 0602 haplotype associated with attenuated protection from type 1 diabetes_mellitus .
16437632	0	DQB1	33,37	DRB1	44,48	DQB1	DRB1	3119	3123	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Human leukocyte antigen class II DQB1 * 0301 , DRB1 * 1101 alleles and spontaneous clearance of hepatitis_C_virus infection : a meta-analysis .
1679052	0	DQB1	69,73	DRB1	57,61	DQB1	DRB1	3119	3123	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular analysis of the role of the HLA class II genes DRB1 , DQA1 , DQB1 , and DPB1 in susceptibility to Lyme_arthritis .
17900288	0	DQB1	48,52	DRB1	36,40	DQB1	DRB1	3119	3125	Gene	Gene	DPB1|compound|START_ENTITY END_ENTITY|dep|DPB1	HLA class I -LRB- A , B , C -RRB- and class II -LRB- DRB1 , DQA1 , DQB1 , DPB1 -RRB- alleles and haplotypes in the Han from southern China .
18086267	0	DQB1	26,30	DRB1	16,20	DQB1	DRB1	3119	3123	Gene	Gene	START_ENTITY|compound|HLA-A HLA-A|dep|END_ENTITY	HLA-A , - B , - C , - DRB1 and - DQB1 alleles and haplotypes in the Kinh population in Vietnam .
18726686	0	DQB1	47,51	DRB1	25,29	DQB1	DRB1	3119	3123	Gene	Gene	0602|compound|START_ENTITY 1501|appos|0602 1501|compound|END_ENTITY	Analysis of HLA DR2_DQ6 -LRB- DRB1 * 1501 , DQA1 * 0102 , DQB1 * 0602 -RRB- haplotypes in Iranian patients with multiple_sclerosis .
20665979	0	DQB1	50,54	DRB1	39,43	DQB1	DRB1	3119	3123	Gene	Gene	recognized|advmod|START_ENTITY epitopes|parataxis|recognized epitopes|xcomp|bound bound|xcomp|END_ENTITY	Three novel NY-ESO-1 epitopes bound to DRB1 * 0803 , DQB1 * 0401 and DRB1 * 0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients .
24374041	0	DQB1	26,30	DRB1	16,20	DQB1	DRB1	3119	3123	Gene	Gene	START_ENTITY|compound|HLA-A HLA-A|dep|END_ENTITY	HLA-A , - B , - C , - DRB1 and - DQB1 allele and haplotype frequencies in the Serbian population .
26684212	0	DQB1	65,69	DRB1	52,56	DQB1	DRB1	3119	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Immunogenetics of three novel HLA-Class II alleles : DRB1 * 03:112 , DQB1 * 03:02:16 and DQB1 * 03:139 .
8226139	0	DQB1	37,41	DRB1	25,29	DQB1	DRB1	3119	3123	Gene	Gene	haplotypes|compound|START_ENTITY associated|nsubjpass|haplotypes associated|nsubjpass|Combinations Combinations|nmod|END_ENTITY	Combinations of specific DRB1 , DQA1 , DQB1 haplotypes are associated with insulin-dependent_diabetes_mellitus in Sardinia .
8741915	0	DQB1	9,13	DRB1	4,8	DQB1	DRB1	3119	3123	Gene	Gene	*|compound|START_ENTITY haplotype|nsubj|* predict|dep|haplotype predict|nsubj|END_ENTITY	HLA DRB1 * DQB1 * haplotype in HTLV-I-associated familial infective_dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic_paraparesis .
9271820	0	DQB1	31,35	DRB1	9,13	DQB1	DRB1	3119	3123	Gene	Gene	START_ENTITY|nsubj|1501 1501|compound|END_ENTITY	Maternal DRB1 * 1501 , DQA1 * 0102 , DQB1 * 0602 haplotype in fetomaternal alloimmunization against human platelet alloantigen HPA-6b -LRB- GPIIIa-Gln489 -RRB- .
9389325	0	DQB1	106,110	DRB1	95,99	DQB1	DRB1	3119	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	High-resolution DNA typing in immunoglobulin_A deficiency confirms a positive association with DRB1 * 0301 , DQB1 * 02 haplotypes .
10200357	0	DQB1	27,31	HLA-DRB1	17,25	DQB1	HLA-DRB1	3119	3123	Gene	Gene	START_ENTITY|nsubj|Polymorphism Polymorphism|nmod|END_ENTITY	-LSB- Polymorphism of HLA-DRB1 , DQB1 in the Hans of north China -RSB- OBJECTIVE : To understand polymorphism of HLA-DRB1 , DQB1 in the Hans of north China and obtain more comprehensive and accurate data on genetics at DNA level .
10331158	0	DQB1	26,30	HLA-DRB1	17,25	DQB1	HLA-DRB1	3119	3123	Gene	Gene	alleles|nummod|START_ENTITY Distributions|dep|alleles Distributions|nmod|END_ENTITY	Distributions of HLA-DRB1 / DQB1 alleles and haplotypes in the north-eastern Thai population : indicative of a distinct Thai population with Chinese admixtures in the central Thais .
12144622	0	DQB1	38,42	HLA-DRB1	22,30	DQB1	HLA-DRB1	3119	3123	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Molecular analysis of HLA-DRB1 , DQA1 , DQB1 , DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico .
12823769	0	DQB1	12,16	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	*|compound|START_ENTITY *|dep|* *|compound|END_ENTITY	HLA-DRB1 * , - DQB1 * in Piramalai Kallars and Yadhavas , two Dravidian-speaking castes of Tamil Nadu , South India .
15985473	0	DQB1	35,39	HLA-DRB1	26,34	DQB1	HLA-DRB1	3119	3123	Gene	Gene	alleles|nsubj|START_ENTITY Contribution|parataxis|alleles Contribution|nmod|END_ENTITY	Contribution of selective HLA-DRB1 / DQB1 alleles and haplotypes to the genetic susceptibility of type_1_diabetes among Lebanese and Bahraini Arabs .
16573562	0	DQB1	11,15	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	alleles|nsubj|START_ENTITY alleles|ccomp|END_ENTITY	HLA-DRB1 , - DQB1 alleles in head_and_neck_carcinoma patients .
17047287	0	DQB1	84,88	HLA-DRB1	74,82	DQB1	HLA-DRB1	3119	3123	Gene	Gene	alleles|nummod|START_ENTITY END_ENTITY|appos|alleles	Is the association between TNF-alpha-308 A allele and DMT1 independent of HLA-DRB1 , DQB1 alleles ?
17389015	0	DQB1	33,37	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	*|nmod|START_ENTITY *|nsubj|END_ENTITY	HLA-DRB1 * 0402 haplotypes without DQB1 * 0302 in Venezuelan patients with pemphigus_vulgaris .
17531857	0	DQB1	28,32	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	DQB1|ccomp|START_ENTITY END_ENTITY|acl:relcl|DQB1	HLA-DRB1 * 1501 , - DQB1 * 0301 , - DQB1 * 0302 , - DQB1 * 0602 , and - DQB1 * 0603 alleles are associated with more severe disease outcome on MRI in patients with multiple_sclerosis .
17531857	0	DQB1	40,44	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	DQB1|ccomp|START_ENTITY DQB1|ccomp|DQB1 END_ENTITY|acl:relcl|DQB1	HLA-DRB1 * 1501 , - DQB1 * 0301 , - DQB1 * 0302 , - DQB1 * 0602 , and - DQB1 * 0603 alleles are associated with more severe disease outcome on MRI in patients with multiple_sclerosis .
19005023	0	DQB1	42,46	HLA-DRB1	33,41	DQB1	HLA-DRB1	3119	3123	Gene	Gene	haplotypes|nummod|START_ENTITY Influence|dep|haplotypes Influence|nmod|END_ENTITY	Influence of common and specific HLA-DRB1 / DQB1 haplotypes on genetic susceptibilities of three distinct Arab populations to type_1_diabetes .
21091360	0	DQB1	38,42	HLA-DRB1	27,35	DQB1	HLA-DRB1	3119	3123	Gene	Gene	polymorphism|compound|START_ENTITY analysis|dep|polymorphism analysis|nmod|END_ENTITY	Association analysis about HLA-DRB1 , - DQB1 polymorphism and auto-antibodies against a -LRB- 1 -RRB- - adrenergic receptors in Chinese patients with essential hypertension .
21652028	0	DQB1	9,13	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	susceptibility|nsubj|START_ENTITY END_ENTITY|appos|susceptibility	HLA-DRB1 / DQB1 susceptibility for autoimmune_polyglandular_syndrome_type_II and III in south of Tunisia .
24055898	0	DQB1	79,83	HLA-DRB1	64,72	DQB1	HLA-DRB1	3119	3123	Gene	Gene	conferred|ccomp|START_ENTITY conferred|nmod|END_ENTITY	The HLA-B * 39 allele increases type 1 diabetes risk conferred by HLA-DRB1 * 04:04 - DQB1 * 03:02 and HLA-DRB1 * 08-DQB1 * 04 class II haplotypes .
25636575	0	DQB1	37,41	HLA-DRB1	17,25	DQB1	HLA-DRB1	3119	3123	Gene	Gene	-LRB-|compound|START_ENTITY END_ENTITY|appos|-LRB-	A rare ancestral HLA-DRB1 -LRB- -RRB- 15:01 DQB1 -LRB- -RRB- 02:01 haplotype and its reversion in the same Western European family .
27056075	0	DQB1	20,24	HLA-DRB1	11,19	DQB1	HLA-DRB1	3119	3123	Gene	Gene	Variants|compound|START_ENTITY Effects|dep|Variants Effects|nmod|END_ENTITY	Effects of HLA-DRB1 / DQB1 Genetic Variants on Neuroimaging in Healthy , Mild Cognitive_Impairment , and Alzheimer 's _ Disease Cohorts .
7495781	0	DQB1	108,112	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	locus|nummod|START_ENTITY insulin-dependent_diabetes_mellitus|nmod|locus associated|nmod|insulin-dependent_diabetes_mellitus associated|nsubjpass|0401 0401|compound|END_ENTITY	HLA-DRB1 * 0401 is associated with susceptibility to insulin-dependent_diabetes_mellitus independently of the DQB1 locus .
8026985	0	DQB1	45,49	HLA-DRB1	28,36	DQB1	HLA-DRB1	3119	3123	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Complete association of the HLA-DRB1 * 04 and - DQB1 * 04 alleles with Vogt-Koyanagi-Harada 's _ disease .
8496614	0	DQB1	102,106	HLA-DRB1	72,80	DQB1	HLA-DRB1	3119	3123	Gene	Gene	0303|compound|START_ENTITY extended|nsubj|0303 reveals|parataxis|extended reveals|nmod|END_ENTITY	Oligonucleotide typing reveals association of type_I_psoriasis with the HLA-DRB1 * 0701/2 , - DQA1 * 0201 , - DQB1 * 0303 extended haplotype .
8851725	0	DQB1	16,20	HLA-DRB1	0,8	DQB1	HLA-DRB1	3119	3123	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	HLA-DRB1 , DQA1 , DQB1 DNA polymorphism in the Bulgarian population .
20599935	0	DQb1	11,15	DRb1	0,4	DQb1	DRb1	3119	3123	Gene	Gene	1501|appos|START_ENTITY *|dobj|1501 *|nsubj|END_ENTITY	DRb1 * 1501 , DQb1 * 0602 donor allelic haplotype and humoral antibody episodes of acute renal allograft rejection .
22219644	0	DR3	16,19	CD4	34,37	DR3	CD4	85030(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Upregulation of DR3 expression in CD4 T cells promotes secretion of IL-17 in experimental autoimmune uveitis .
15241467	0	DR3	18,21	Death_receptor_3	0,16	DR3	Death receptor 3	8718	8718	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Death_receptor_3 -LRB- DR3 -RRB- gene duplication in a chromosome region 1p36 .3 : gene duplication is more prevalent in rheumatoid_arthritis .
11911831	0	DR3	30,33	TL1A	0,4	DR3	TL1A	8718	9966	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator .
26718429	0	DR4	126,129	Death_Receptor	110,124	DR4	Death Receptor	8797	8797	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Genetic variants in the tumor_Necrosis_Factor-Related_Apoptosis-Inducing_Ligand -LRB- TRAIL -RRB- do not contribute but Death_Receptor -LRB- DR4 -RRB- genes may contribute to susceptibility to head_and_neck_cancer in Pakistani population .
25207117	0	DR4	43,46	Death_Receptor_4	25,41	DR4	Death Receptor 4	8797	8797	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	A Study of the Impact of Death_Receptor_4 -LRB- DR4 -RRB- Gene Polymorphisms in Alzheimer 's _ Disease .
18421578	0	DR4	18,21	Death_receptor-4	0,16	DR4	Death receptor-4	8797	8797	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Death_receptor-4 -LRB- DR4 -RRB- expression is regulated by transcription factor NF-kappaB in response to etoposide treatment .
10762627	0	DR4	42,45	TRAIL	107,112	DR4	TRAIL	8797	8743	Gene	Gene	gene|compound|START_ENTITY deletion|nmod|gene associated|nsubjpass|deletion associated|nmod|resistance resistance|amod|END_ENTITY	Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal_cancer cell line is associated with TRAIL resistance .
12831538	0	DR4	96,99	TRAIL	70,75	DR4	TRAIL	8797	8743	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|Preparation Preparation|nmod|set set|nmod|antibodies antibodies|nmod|END_ENTITY	Preparation and characterization of a set of monoclonal antibodies to TRAIL and TRAIL receptors DR4 , DR5 , DcR1 , and DcR2 .
15354201	0	DR4	18,21	TRAIL	155,160	DR4	TRAIL	8797	8743	Gene	Gene	efficiently|appos|START_ENTITY kills|nsubj|efficiently kills|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Death_receptor_4 -LRB- DR4 -RRB- efficiently kills breast_cancer cells irrespective of their sensitivity to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- .
15356269	0	DR4	53,56	TRAIL	31,36	DR4	TRAIL	8797	8743	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|regulation regulation|nmod|death death|compound|END_ENTITY	Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle .
15972852	0	DR4	108,111	TRAIL	116,121	DR4	TRAIL	8797	8743	Gene	Gene	receptor|appos|START_ENTITY inducing|dobj|receptor inducing|nmod|resistance resistance|amod|END_ENTITY	Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 -LRB- DR4 -RRB- to TRAIL resistance and ovarian_cancer .
16502485	0	DR4	96,99	TRAIL	19,24	DR4	TRAIL	8797	8743	Gene	Gene	expression|nmod|START_ENTITY expression|compound|treatment treatment|amod|END_ENTITY	The combination of TRAIL treatment and cancer cell selective expression of TRAIL-death receptor DR4 induces cell death in TRAIL-resistant cancer cells .
16529749	0	DR4	35,38	TRAIL	143,148	DR4	TRAIL	3126	8743	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|advcl|END_ENTITY	Alpha-tocopheryl_succinate induces DR4 and DR5 expression by a p53-dependent route : implication for sensitisation of resistant cancer cells to TRAIL apoptosis .
17143496	0	DR4	113,116	TRAIL	37,42	DR4	TRAIL	3126	8743	Gene	Gene	up-regulation|nmod|START_ENTITY TRAIL|nmod|up-regulation sensitizes|xcomp|TRAIL sensitizes|nsubj|Phytosphingosine Phytosphingosine|nmod|combination combination|nmod|END_ENTITY	Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5 .
17143496	0	DR4	113,116	TRAIL	70,75	DR4	TRAIL	3126	8743	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5 .
17666396	0	DR4	86,89	TRAIL	31,36	DR4	TRAIL	8797	8743	Gene	Gene	receptor|compound|START_ENTITY signaling|nmod|receptor inhibit|dep|signaling inhibit|nsubj|mutations mutations|nmod|DR5 DR5|compound|END_ENTITY	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding .
17666396	0	DR4	86,89	TRAIL	58,63	DR4	TRAIL	8797	8743	Gene	Gene	receptor|compound|START_ENTITY signaling|nmod|receptor signaling|nsubj|END_ENTITY	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding .
17881904	0	DR4	160,163	TRAIL	89,94	DR4	TRAIL	3126	8743	Gene	Gene	expression|nmod|START_ENTITY non-SP|appos|expression END_ENTITY|nmod|non-SP	Chemotherapy-resistant side-population of colon_cancer cells has a higher sensitivity to TRAIL than the non-SP , a higher expression of c-Myc and TRAIL-receptor DR4 .
19148581	0	DR4	34,37	TRAIL	91,96	DR4	TRAIL	8797	8743	Gene	Gene	expression|appos|START_ENTITY Reactivation|nmod|expression sensitizes|nsubj|Reactivation sensitizes|nmod|END_ENTITY	Reactivation of death_receptor_4 -LRB- DR4 -RRB- expression sensitizes medulloblastoma cell lines to TRAIL .
19305384	0	DR4	44,47	TRAIL	14,19	DR4	TRAIL	8797	8743	Gene	Gene	correlates|compound|START_ENTITY receptors|dobj|correlates receptors|nsubj|Expression Expression|nmod|END_ENTITY	Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks .
20041491	0	DR4	154,157	TRAIL	85,90	DR4	TRAIL	8797	8743	Gene	Gene	death_receptor_4|appos|START_ENTITY up-regulations|nmod|death_receptor_4 induced|nmod|up-regulations tumor_necrosis_factor-related_apoptosis-inducing_ligand|acl:relcl|induced tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Ionizing radiation enhances tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis through up-regulations of death_receptor_4 -LRB- DR4 -RRB- and death_receptor_5 -LRB- DR5 -RRB- in human osteosarcoma cells .
20354842	0	DR4	31,34	TRAIL	0,5	DR4	TRAIL	8797	8743	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|signaling signaling|compound|END_ENTITY	TRAIL signaling is mediated by DR4 in pancreatic_tumor cells despite the expression of functional DR5 .
21272366	0	DR4	84,87	TRAIL	14,19	DR4	TRAIL	3126	8743	Gene	Gene	contributions|nmod|START_ENTITY Modulation|dep|contributions Modulation|nmod|resistance resistance|amod|END_ENTITY	Modulation of TRAIL resistance in colon_carcinoma cells : different contributions of DR4 and DR5 .
21279373	0	DR4	54,57	TRAIL	24,29	DR4	TRAIL	3126	8743	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|expression expression|nmod|END_ENTITY	Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque_psoriasis .
21769428	0	DR4	18,21	TRAIL	77,82	DR4	TRAIL	8797	8743	Gene	Gene	Redistribution|nmod|START_ENTITY accounts|nsubj|Redistribution accounts|nmod|sensitivity sensitivity|acl|END_ENTITY	Redistribution of DR4 and DR5 in lipid rafts accounts for the sensitivity to TRAIL in NSCLC cells .
22401174	0	DR4	18,21	TRAIL	0,5	DR4	TRAIL	3126	8743	Gene	Gene	I|appos|START_ENTITY I|amod|END_ENTITY	TRAIL receptor I -LRB- DR4 -RRB- polymorphisms C626G and A683C are associated with an increased risk for hepatocellular_carcinoma -LRB- HCC -RRB- in HCV-infected patients .
22802267	0	DR4	48,51	TRAIL	10,15	DR4	TRAIL	3126	8743	Gene	Gene	complexes|compound|START_ENTITY 4|nmod|complexes receptor|dep|4 receptor|amod|END_ENTITY	Targeting TRAIL death receptor 4 with trivalent DR4 Atrimer complexes .
23686163	0	DR4	85,88	TRAIL	97,102	DR4	TRAIL	8797	8743	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Notch inhibition restores TRAIL-mediated apoptosis via AP1-dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231_breast_cancer cells .
24661673	0	DR4	73,76	TRAIL	15,20	DR4	TRAIL	8797	8743	Gene	Gene	island|compound|START_ENTITY hypermethylation|nmod|island Development|nmod|hypermethylation Development|nmod|resistance resistance|amod|END_ENTITY	Development of TRAIL resistance by radiation-induced hypermethylation of DR4 CpG island in recurrent laryngeal_squamous_cell_carcinoma .
25310712	0	DR4	144,147	TRAIL	15,20	DR4	TRAIL	8797	8743	Gene	Gene	internalization|nmod|START_ENTITY shifted|nmod|internalization shifted|nsubj|Combination Combination|nmod|END_ENTITY	Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4 .
25310712	0	DR4	70,73	TRAIL	15,20	DR4	TRAIL	8797	8743	Gene	Gene	DR5|compound|START_ENTITY receptor|nummod|DR5 shifted|nmod|receptor shifted|nsubj|Combination Combination|nmod|END_ENTITY	Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4 .
25364476	0	DR4	34,37	TRAIL	100,105	DR4	TRAIL	8797	8743	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|sensitivity sensitivity|amod|END_ENTITY	Identification of death receptors DR4 and DR5 in HTB-12 astrocytoma cell lines and determination of TRAIL sensitivity .
25482930	0	DR4	0,3	TRAIL	13,18	DR4	TRAIL	8797	8743	Gene	Gene	variants|nummod|START_ENTITY variants|amod|END_ENTITY	DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic_cancer .
25482930	0	DR4	0,3	TRAIL	64,69	DR4	TRAIL	8797	8743	Gene	Gene	variants|nummod|START_ENTITY efficacious|nsubj|variants efficacious|nmod|END_ENTITY	DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic_cancer .
26238205	0	DR4	10,13	TRAIL	42,47	DR4	TRAIL	3126	8743	Gene	Gene	methylation|compound|START_ENTITY methylation|nmod|END_ENTITY	Effect of DR4 promoter methylation on the TRAIL - induced apoptosis in lung_squamous_carcinoma cell .
26518902	0	DR4	108,111	TRAIL	81,86	DR4	TRAIL	8797	8743	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Genetic variants in the tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- and death_receptor -LRB- DR4 -RRB- genes contribute to susceptibility to colorectal_cancer in pakistani population .
24761920	0	DR4	15,18	TRAIL-R1	20,28	DR4	TRAIL-R1	8797	8797	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of DR4 -LRB- TRAIL-R1 -RRB- polymorphisms with cancer risk in Caucasians : an updated meta-analysis .
19148581	0	DR4	34,37	death_receptor_4	16,32	DR4	death receptor 4	8797	8797	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Reactivation of death_receptor_4 -LRB- DR4 -RRB- expression sensitizes medulloblastoma cell lines to TRAIL .
19350268	0	DR4	26,29	death_receptor_4	8,24	DR4	death receptor 4	8797	8797	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lack of death_receptor_4 -LRB- DR4 -RRB- expression through gene promoter methylation in gastric_carcinoma .
15109535	0	DR4/DR5	59,66	CD95	32,36	DR4/DR5	CD95	8797;8795	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Prognostic significance of Fas -LRB- CD95 -RRB- and TRAIL receptors -LRB- DR4/DR5 -RRB- expression in acute_myelogenous_leukemia .
15208670	0	DR4/DR5	69,76	IG20	0,4	DR4/DR5	IG20	8797;8795	8567	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	IG20 -LRB- MADD splice variant-5 -RRB- , a proapoptotic protein , interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC .
18992144	0	DR5	84,87	Hepatocyte_growth_factor	0,24	DR5	Hepatocyte growth factor	8795	3082	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Hepatocyte_growth_factor enhances death receptor-induced apoptosis by up-regulating DR5 .
18544564	0	DR5	75,78	Hypoxia-inducible_factor-2alpha	0,31	DR5	Hypoxia-inducible factor-2alpha	8795	2034	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor-2alpha regulates the expression of TRAIL receptor DR5 in renal_cancer cells .
3890265	0	DR5	115,118	MB1	121,124	DR5	MB1	8795	5693	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Immunochemical analysis of class II molecules expressed by a human B cell line with the unusual class II genotype , DR5 + , MB1 + , -LRB- MB3 - -RRB- , MT2 + .
21811429	0	DR5	21,24	MG132	60,65	DR5	MG132	8795	875581(Tax:243273)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of the DR5 expression by proteasome inhibitor MG132 augments TRAIL-induced apoptosis in soft tissue sarcoma cell lines .
21822052	0	DR5	42,45	Mcl-1	0,5	DR5	Mcl-1	8795	4170	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax -LRB- GX15-070 -RRB- contribute in the sensitization of B-NHL cells to TRAIL apoptosis .
12207174	0	DR5	95,98	TRAIL	57,62	DR5	TRAIL	8795	8743	Gene	Gene	death_receptor_5|appos|START_ENTITY mediated|nsubj|death_receptor_5 mediated|dep|END_ENTITY	Tumor_necrosis_factor-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- up-regulates death_receptor_5 -LRB- DR5 -RRB- mediated by NFkappaB activation in epithelial derived cell lines .
15987718	0	DR5	177,180	TRAIL	77,82	DR5	TRAIL	8795	8743	Gene	Gene	death_receptor_5|appos|START_ENTITY upregulation|nmod|death_receptor_5 apoptosis|nmod|upregulation necrosis|dep|apoptosis necrosis|dep|ligand ligand|appos|END_ENTITY	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced apoptosis through reactive oxygen species-mediated upregulation of death_receptor_5 -LRB- DR5 -RRB- .
16357524	0	DR5	102,105	TRAIL	88,93	DR5	TRAIL	8795	8743	Gene	Gene	upregulation|nummod|START_ENTITY END_ENTITY|nmod|upregulation	Adenovirus E1A reverses the resistance of normal primary human lung fibroblast cells to TRAIL through DR5 upregulation and caspase_8-dependent pathway .
16452234	0	DR5	198,201	TRAIL	81,86	DR5	TRAIL	8795	8743	Gene	Gene	up-regulation|nmod|START_ENTITY sensitizes|nmod|up-regulation sensitizes|dobj|necrosis necrosis|dep|ligand ligand|appos|END_ENTITY	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 .
16613838	0	DR5	128,131	TRAIL	77,82	DR5	TRAIL	8795	8743	Gene	Gene	apoptosis|nmod|START_ENTITY sensitizes|dep|apoptosis sensitizes|appos|END_ENTITY	Curcumin sensitizes tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis through CHOP-independent DR5 upregulation .
17666396	0	DR5	46,49	TRAIL	58,63	DR5	TRAIL	8795	8743	Gene	Gene	mutations|nmod|START_ENTITY inhibit|nsubj|mutations inhibit|dep|signaling signaling|nsubj|END_ENTITY	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding .
18476767	0	DR5	133,136	TRAIL	0,5	DR5	TRAIL	8795	8743	Gene	Gene	apoptosis|nmod|START_ENTITY triggers|dobj|apoptosis triggers|nsubj|adenovirus adenovirus|amod|END_ENTITY	TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60 / Vinc cells preferentially through death receptor DR5 .
18483298	0	DR5	82,85	TRAIL	67,72	DR5	TRAIL	8795	8743	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Proteasome inhibitor PS-341 -LRB- VELCADE -RRB- induces stabilization of the TRAIL receptor DR5 mRNA through the 3 ' - untranslated region .
19577358	0	DR5	143,146	TRAIL	75,80	DR5	TRAIL	8795	8743	Gene	Gene	death_receptor_5|appos|START_ENTITY up-regulation|nmod|death_receptor_5 induced|nmod|up-regulation ligand|acl:relcl|induced ligand|appos|END_ENTITY	Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced apoptosis through up-regulation of death_receptor_5 -LRB- DR5 -RRB- in human sarcoma_HOS cells and human colon_cancer HCT116 cells .
20041491	0	DR5	181,184	TRAIL	85,90	DR5	TRAIL	8795	8743	Gene	Gene	death_receptor_4|appos|START_ENTITY up-regulations|nmod|death_receptor_4 induced|nmod|up-regulations tumor_necrosis_factor-related_apoptosis-inducing_ligand|acl:relcl|induced tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Ionizing radiation enhances tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis through up-regulations of death_receptor_4 -LRB- DR4 -RRB- and death_receptor_5 -LRB- DR5 -RRB- in human osteosarcoma cells .
20103630	0	DR5	12,15	TRAIL	38,43	DR5	TRAIL	8795	8743	Gene	Gene	peptides|compound|START_ENTITY activate|nsubj|peptides activate|dobj|pathway pathway|amod|END_ENTITY	Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity .
20159939	0	DR5	258,261	TRAIL	141,146	DR5	TRAIL	8795	8743	Gene	Gene	death_receptor_5|appos|START_ENTITY cells|dep|death_receptor_5 cells|dep|ligand ligand|appos|END_ENTITY	The synthetic cannabinoid WIN_55 ,212 -2 sensitizes hepatocellular_carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced apoptosis by activating p8/CCAAT/enhancer _ binding_protein_homologous_protein -LRB- CHOP -RRB- / death_receptor_5 -LRB- DR5 -RRB- axis .
20354842	0	DR5	98,101	TRAIL	0,5	DR5	TRAIL	8795	8743	Gene	Gene	expression|nmod|START_ENTITY mediated|nmod|expression mediated|nsubjpass|signaling signaling|compound|END_ENTITY	TRAIL signaling is mediated by DR4 in pancreatic_tumor cells despite the expression of functional DR5 .
20840533	0	DR5	88,91	TRAIL	57,62	DR5	TRAIL	8795	8743	Gene	Gene	START_ENTITY|nsubj|Tumor_necrosis_factor-related_apoptosis-inducing_ligand Tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- and its death_receptor -LRB- DR5 -RRB- in Peyronie 's _ disease .
21152876	0	DR5	187,190	TRAIL	110,115	DR5	TRAIL	8795	8743	Gene	Gene	upregulation|nmod|START_ENTITY sensitizes|advcl|upregulation sensitizes|dobj|cells cells|acl|END_ENTITY	Cisplatin sensitizes human hepatocellular_carcinoma cells , but not hepatocytes and mesenchymal stem cells , to TRAIL within a therapeutic window partially depending on the upregulation of DR5 .
21697087	0	DR5	81,84	TRAIL	211,216	DR5	TRAIL	8795	8743	Gene	Gene	expression|compound|START_ENTITY binding_protein_homologous_protein|dep|expression Modulation|nmod|binding_protein_homologous_protein sensitizes|nsubj|Modulation sensitizes|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Modulation of CCAAT/enhancer _ binding_protein_homologous_protein -LRB- CHOP -RRB- - dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- .
21822052	0	DR5	42,45	TRAIL	136,141	DR5	TRAIL	8795	8743	Gene	Gene	inhibition|nmod|START_ENTITY contribute|nsubj|inhibition contribute|nmod|apoptosis apoptosis|amod|END_ENTITY	Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax -LRB- GX15-070 -RRB- contribute in the sensitization of B-NHL cells to TRAIL apoptosis .
21877938	0	DR5	103,106	TRAIL	19,24	DR5	TRAIL	8795	8743	Gene	Gene	up-regulation|nmod|START_ENTITY restores|nmod|up-regulation restores|dobj|pathway pathway|amod|END_ENTITY	Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP .
22020938	0	DR5	71,74	TRAIL	150,155	DR5	TRAIL	8795	8743	Gene	Gene	death_receptor_5|appos|START_ENTITY localization|nmod|death_receptor_5 limits|nsubj|localization limits|dobj|factor factor|dep|ligand ligand|appos|END_ENTITY	Importin b1 protein-mediated nuclear localization of death_receptor_5 -LRB- DR5 -RRB- limits DR5/tumor necrosis factor -LRB- TNF -RRB- - related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced cell death of human tumor cells .
22419388	0	DR5	111,114	TRAIL	90,95	DR5	TRAIL	21933(Tax:10090)	22035(Tax:10090)	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	Induction of proapoptotic antibodies to triple-negative_breast_cancer by vaccination with TRAIL death receptor DR5 DNA .
23224239	0	DR5	113,116	TRAIL	53,58	DR5	TRAIL	8795	8743	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5 .
23247197	0	DR5	153,156	TRAIL	126,131	DR5	TRAIL	8795	8743	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP .
24866585	0	DR5	107,110	TRAIL	65,70	DR5	TRAIL	8795	8743	Gene	Gene	upregulation|compound|START_ENTITY upregulation|amod|triple-negative_breast_cancer triple-negative_breast_cancer|nmod|END_ENTITY	YM155 sensitizes triple-negative_breast_cancer to membrane-bound TRAIL through p38 MAPK - and CHOP-mediated DR5 upregulation .
24939851	0	DR5	285,288	TRAIL	216,221	DR5	TRAIL	8795	8743	Gene	Gene	death_receptor_5|appos|START_ENTITY up-regulation|nmod|death_receptor_5 mediated|nmod|up-regulation mediated|nsubj|Role Role|nmod|reticulum reticulum|acl:relcl|necrosis necrosis|dobj|factor factor|dep|ligand ligand|appos|END_ENTITY	Role of activating_transcription_factor_3 -LRB- ATF3 -RRB- in endoplasmic reticulum -LRB- ER -RRB- stress-induced sensitization of p53-deficient human colon_cancer cells to tumor necrosis factor -LRB- TNF -RRB- - related apoptosis-inducing ligand -LRB- TRAIL -RRB- - mediated apoptosis through up-regulation of death_receptor_5 -LRB- DR5 -RRB- by zerumbone and celecoxib .
25310712	0	DR5	77,80	TRAIL	15,20	DR5	TRAIL	8795	8743	Gene	Gene	receptor|nummod|START_ENTITY shifted|nmod|receptor shifted|nsubj|Combination Combination|nmod|END_ENTITY	Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4 .
25882551	0	DR5	38,41	TRAIL	15,20	DR5	TRAIL	8795	8743	Gene	Gene	clustering|compound|START_ENTITY induces|dobj|clustering induces|nsubj|END_ENTITY	Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic_lymphoma U937 cells .
26074143	0	DR5	97,100	TRAIL	29,34	DR5	TRAIL	8795	8743	Gene	Gene	cells|nmod|START_ENTITY enhances|nmod|cells enhances|dobj|cytotoxicity cytotoxicity|amod|END_ENTITY	RAD001 -LRB- everolimus -RRB- enhances TRAIL cytotoxicity in human leukemic Jurkat T cells by upregulating DR5 .
26385392	0	DR5	73,76	TRAIL	133,138	DR5	TRAIL	8795	8743	Gene	Gene	antibody|compound|START_ENTITY cytotoxicity|nmod|antibody encoding|nsubj|cytotoxicity encoding|dobj|END_ENTITY	Targeted radiotherapy potentiates the cytotoxicity of a novel anti-human DR5 monoclonal antibody and the adenovirus encoding soluble TRAIL in prostate_cancer .
26547077	0	DR5	63,66	TRAIL	54,59	DR5	TRAIL	8795	8743	Gene	Gene	Receptor|compound|START_ENTITY END_ENTITY|nmod|Receptor	Mutations Enhancing Selectivity of Antitumor Cytokine TRAIL to DR5 Receptor Increase Its Cytotoxicity against Tumor Cells .
26577955	0	DR5	45,48	TRAIL	189,194	DR5	TRAIL	8795	8743	Gene	Gene	expression|appos|START_ENTITY associated|nsubj|expression associated|nmod|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	The enhanced expression of death receptor 5 -LRB- DR5 -RRB- mediated by HBV X protein through NF-kappaB pathway is associated with cell apoptosis induced by -LRB- TNF-a related apoptosis inducing ligand -RRB- TRAIL in hepatoma cells .
26952193	0	DR5	9,12	TRAIL	48,53	DR5	TRAIL	8795	8743	Gene	Gene	capacity|compound|START_ENTITY capacity|nmod|END_ENTITY	Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studies .
18093694	0	DR5	100,103	TRAIL-R2	91,99	DR5	TRAIL-R2	8795	8795	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2 / DR5 expression in the absence of caspase-8 .
17431117	0	DR5	92,95	Yin_Yang_1	114,124	DR5	Yin Yang 1	8795	7528	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis : up-regulation of DR5 and inhibition of Yin_Yang_1 .
17804742	0	DR5	72,75	c-FLIP	113,119	DR5	c-FLIP	8795	8837	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin .
18087262	0	DR5	0,3	caspase-8	18,27	DR5	caspase-8	8795	841	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo .
18093694	0	DR5	100,103	caspase-8	133,142	DR5	caspase-8	8795	841	Gene	Gene	expression|compound|START_ENTITY dependent|nmod|expression dependent|nmod|absence absence|nmod|END_ENTITY	TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2 / DR5 expression in the absence of caspase-8 .
20515942	0	DR5	122,125	extracellular_signal-regulated_kinase	70,107	DR5	extracellular signal-regulated kinase	8795	5594	Gene	Gene	upregulation|compound|START_ENTITY upregulation|amod|END_ENTITY	Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular_signal-regulated_kinase / Sp1-dependent DR5 upregulation and NF-kappaB inactivation .
19225519	0	DR6	10,13	APP	0,3	DR6	APP	94185(Tax:10090)	11820(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	APP binds DR6 to trigger axon pruning and neuron_death via distinct caspases .
11753679	0	DR6	54,57	NF-kappaB	118,127	DR6	NF-kappaB	27242	4790	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of DR6 , a member of the TNF receptor family , through activation of NF-kappaB .
11753679	0	DR6	54,57	Tumor_necrosis_factor-alpha	0,27	DR6	Tumor necrosis factor-alpha	27242	7124	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of DR6 , a member of the TNF receptor family , through activation of NF-kappaB .
25838500	0	DR6	25,28	amyloid_precursor_protein	49,74	DR6	amyloid precursor protein	27242	351	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	The crystal structure of DR6 in complex with the amyloid_precursor_protein provides insight into death receptor activation .
10898717	0	DRA	31,34	CFTR	0,4	DRA	CFTR	1811	1080	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	CFTR induces the expression of DRA along with Cl -LRB- - -RRB- / HCO -LRB- 3 -RRB- -LRB- - -RRB- exchange activity in tracheal epithelial cells .
7935445	0	DRA	20,23	Ets-1	0,5	DRA	Ets-1	1811	2113	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Ets-1 activates the DRA promoter in B cells .
25887398	0	DRA	43,46	SLC26A3	34,41	DRA	SLC26A3	1811	1811	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	All-Trans-Retinoic_Acid Increases SLC26A3 -LRB- DRA -RRB- Expression In Intestinal Epithelial Cells Via HNF-1b .
25531329	0	DRAK1	12,17	TGF-b1	66,72	DRAK1	TGF-b1	9263	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
15104677	0	DRB1	18,22	DQA1	11,15	DRB1	DQA1	3123	3117	Gene	Gene	disequilibrium|compound|START_ENTITY HLA-DQB1|dep|disequilibrium HLA-DQB1|appos|END_ENTITY	HLA-DQB1 , - DQA1 , - DRB1 linkage disequilibrium and haplotype diversity in a Mestizo population from Guadalajara , Mexico .
1679052	0	DRB1	57,61	DQA1	63,67	DRB1	DQA1	3123	3117	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular analysis of the role of the HLA class II genes DRB1 , DQA1 , DQB1 , and DPB1 in susceptibility to Lyme_arthritis .
26762682	0	DRB1	32,36	DQA1	44,48	DRB1	DQA1	3123	3117	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Three new HLA class II alleles : DRB1 * 08:70 , DQA1 * 01:13 and DQA1 * 03:01:03 .
7974465	0	DRB1	35,39	DQA1	4,8	DRB1	DQA1	3125	3117	Gene	Gene	1001|compound|START_ENTITY carried|nmod|1001 carried|nsubjpass|allele allele|compound|END_ENTITY	The DQA1 * 0104 allele is carried by DRB1 * 1001 - and DRB1 * 1401-positive haplotypes in Caucasians , Africans and Orientals .
7974465	0	DRB1	50,54	DQA1	4,8	DRB1	DQA1	3125	3117	Gene	Gene	1001|dep|START_ENTITY carried|nmod|1001 carried|nsubjpass|allele allele|compound|END_ENTITY	The DQA1 * 0104 allele is carried by DRB1 * 1001 - and DRB1 * 1401-positive haplotypes in Caucasians , Africans and Orientals .
8071103	0	DRB1	50,54	DQA1	0,4	DRB1	DQA1	3123	3117	Gene	Gene	have|nmod|START_ENTITY alleles|dep|have alleles|nsubj|END_ENTITY	DQA1 * 03 subtypes have different associations with DRB1 and DQB1 alleles .
8226139	0	DRB1	25,29	DQA1	31,35	DRB1	DQA1	3123	3117	Gene	Gene	Combinations|nmod|START_ENTITY associated|nsubjpass|Combinations associated|advmod|END_ENTITY	Combinations of specific DRB1 , DQA1 , DQB1 haplotypes are associated with insulin-dependent_diabetes_mellitus in Sardinia .
9157087	0	DRB1	101,105	DQA1	26,30	DRB1	DQA1	3123	3117	Gene	Gene	association|nmod|START_ENTITY Polymorphism|dep|association Polymorphism|dep|END_ENTITY	Polymorphism of HLA-DRB , _ - DQA1 , and - DQB1 in rheumatoid_arthritis in Asian Indians : association with DRB1 * 0405 and DRB1 * 1001 .
10674966	0	DRB1	41,45	DQB1	53,57	DRB1	DQB1	3123	3119	Gene	Gene	START_ENTITY|appos|DQA1 DQA1|nummod|END_ENTITY	Hardy-Weinberg testing for HLA class II -LRB- DRB1 , DQA1 , DQB1 , and DPB1 -RRB- loci in 26 human ethnic groups .
10931389	0	DRB1	17,21	DQB1	33,37	DRB1	DQB1	3125	3119	Gene	Gene	DPB1|compound|START_ENTITY DPB1|appos|END_ENTITY	HLA-A , _ B , Cw and DRB1 , DRB3/4/5 , DQB1 , DPB1 frequencies in German immunoglobulin A-deficient individuals .
12622908	4	DRB1	872,876	DQB1	885,889	DQB1	DRB1	3119	3123	Gene	Gene	0405|compound|START_ENTITY 0306|appos|0405 0306|appos|END_ENTITY	And the risk to PIH of women with DRB1 * 0306 , DRB1 * 0405 , DQB1 * 0502 were higher than others -LRB- RR : 9.76 , 6.34 , 4.20 -RRB- , and its gene-frequency was higher than controls -LRB- P < 0.01 -RRB- .
1440567	0	DRB1	141,145	DQB1	159,163	DRB1	DQB1	3123	3119	Gene	Gene	homozygotes|compound|START_ENTITY homozygotes|dep|END_ENTITY	Distribution of HLA class II alleles among Scandinavian patients with systemic_lupus_erythematosus -LRB- SLE -RRB- : an increased risk of SLE among non -LSB- DRB1 * 03 , DQA1 * 0501 , DQB1 * 0201 -RSB- class II homozygotes ?
14551034	0	DRB1	13,17	DQB1	19,23	DRB1	DQB1	3123	3119	Gene	Gene	HLA-A|appos|START_ENTITY HLA-A|appos|heterogeneity heterogeneity|compound|END_ENTITY	HLA-A , _ B , _ C , DRB1 , DQB1 matching heterogeneity in ` favourably matched ' kidney recipients .
15853898	0	DRB1	52,56	DQB1	63,67	DRB1	DQB1	3123	3119	Gene	Gene	diversity|dep|START_ENTITY diversity|dep|genes genes|nummod|END_ENTITY	Allelic and haplotypic diversity of HLA-A , - B , - C , - DRB1 , and - DQB1 genes in the Korean population .
15941540	0	DRB1	51,55	DQB1	57,61	DRB1	DQB1	3123	3119	Gene	Gene	analysis|nmod|START_ENTITY -LSB-|dobj|analysis locus|advcl|-LSB- locus|nsubj|END_ENTITY	-LSB- Immunogenetic analysis of human leukocyte antigen DRB1 , DQB1 locus among Han ethnic children with Helicobacter_pylori_infection in Kunming -RSB- .
16320082	0	DRB1	18,22	DQB1	27,31	DRB1	DQB1	3123	3119	Gene	Gene	marks|dobj|START_ENTITY *|acl:relcl|marks *|dep|END_ENTITY	D6S265 * 15 marks a DRB1 * 15 , DQB1 * 0602 haplotype associated with attenuated protection from type 1 diabetes_mellitus .
16437632	0	DRB1	44,48	DQB1	33,37	DRB1	DQB1	3123	3119	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Human leukocyte antigen class II DQB1 * 0301 , DRB1 * 1101 alleles and spontaneous clearance of hepatitis_C_virus infection : a meta-analysis .
1679052	0	DRB1	57,61	DQB1	69,73	DRB1	DQB1	3123	3119	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular analysis of the role of the HLA class II genes DRB1 , DQA1 , DQB1 , and DPB1 in susceptibility to Lyme_arthritis .
17900288	0	DRB1	36,40	DQB1	48,52	DRB1	DQB1	3125	3119	Gene	Gene	START_ENTITY|dep|DPB1 DPB1|compound|END_ENTITY	HLA class I -LRB- A , B , C -RRB- and class II -LRB- DRB1 , DQA1 , DQB1 , DPB1 -RRB- alleles and haplotypes in the Han from southern China .
18086267	0	DRB1	16,20	DQB1	26,30	DRB1	DQB1	3123	3119	Gene	Gene	HLA-A|dep|START_ENTITY END_ENTITY|compound|HLA-A	HLA-A , - B , - C , - DRB1 and - DQB1 alleles and haplotypes in the Kinh population in Vietnam .
18726686	0	DRB1	25,29	DQB1	47,51	DRB1	DQB1	3123	3119	Gene	Gene	1501|compound|START_ENTITY 1501|appos|0602 0602|compound|END_ENTITY	Analysis of HLA DR2_DQ6 -LRB- DRB1 * 1501 , DQA1 * 0102 , DQB1 * 0602 -RRB- haplotypes in Iranian patients with multiple_sclerosis .
20665979	0	DRB1	39,43	DQB1	50,54	DRB1	DQB1	3123	3119	Gene	Gene	bound|xcomp|START_ENTITY epitopes|xcomp|bound epitopes|parataxis|recognized recognized|advmod|END_ENTITY	Three novel NY-ESO-1 epitopes bound to DRB1 * 0803 , DQB1 * 0401 and DRB1 * 0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients .
24374041	0	DRB1	16,20	DQB1	26,30	DRB1	DQB1	3123	3119	Gene	Gene	HLA-A|dep|START_ENTITY END_ENTITY|compound|HLA-A	HLA-A , - B , - C , - DRB1 and - DQB1 allele and haplotype frequencies in the Serbian population .
26684212	0	DRB1	52,56	DQB1	65,69	DRB1	DQB1	3123	3119	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Immunogenetics of three novel HLA-Class II alleles : DRB1 * 03:112 , DQB1 * 03:02:16 and DQB1 * 03:139 .
8226139	0	DRB1	25,29	DQB1	37,41	DRB1	DQB1	3123	3119	Gene	Gene	Combinations|nmod|START_ENTITY associated|nsubjpass|Combinations associated|nsubjpass|haplotypes haplotypes|compound|END_ENTITY	Combinations of specific DRB1 , DQA1 , DQB1 haplotypes are associated with insulin-dependent_diabetes_mellitus in Sardinia .
8741915	0	DRB1	4,8	DQB1	9,13	DRB1	DQB1	3123	3119	Gene	Gene	predict|nsubj|START_ENTITY predict|dep|haplotype haplotype|nsubj|* *|compound|END_ENTITY	HLA DRB1 * DQB1 * haplotype in HTLV-I-associated familial infective_dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic_paraparesis .
9271820	0	DRB1	9,13	DQB1	31,35	DRB1	DQB1	3123	3119	Gene	Gene	1501|compound|START_ENTITY END_ENTITY|nsubj|1501	Maternal DRB1 * 1501 , DQA1 * 0102 , DQB1 * 0602 haplotype in fetomaternal alloimmunization against human platelet alloantigen HPA-6b -LRB- GPIIIa-Gln489 -RRB- .
9389325	0	DRB1	95,99	DQB1	106,110	DRB1	DQB1	3123	3119	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	High-resolution DNA typing in immunoglobulin_A deficiency confirms a positive association with DRB1 * 0301 , DQB1 * 02 haplotypes .
10703621	0	DRB1	33,37	DRB1	44,48	DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Detection of four novel alleles : DRB1 * 1130 , DRB1 * 13072 , DRB1 * 1315 and DRB1 * 1331 .
10703621	0	DRB1	44,48	DRB1	33,37	DRB1	DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Detection of four novel alleles : DRB1 * 1130 , DRB1 * 13072 , DRB1 * 1315 and DRB1 * 1331 .
11532019	0	DRB1	46,50	DRB1	58,62	DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	PCR-RFLP typing detects new HLA-DRB1 alleles : DRB1 * 13022 , DRB1 * 1336 and DRB1 * 1435 .
11532019	0	DRB1	58,62	DRB1	46,50	DRB1	DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	PCR-RFLP typing detects new HLA-DRB1 alleles : DRB1 * 13022 , DRB1 * 1336 and DRB1 * 1435 .
12028548	0	DRB1	86,90	DRB1	98,102	DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Novel HLA-DRB1 alleles discovered during routine sequencing based typing , DRB1 * 03052 , DRB1 * 04032 , DRB1 * 1139 and DRB1 * 1346 .
12028548	0	DRB1	98,102	DRB1	86,90	DRB1	DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Novel HLA-DRB1 alleles discovered during routine sequencing based typing , DRB1 * 03052 , DRB1 * 04032 , DRB1 * 1139 and DRB1 * 1346 .
15496209	0	DRB1	69,73	DRB1	82,86	DRB1	DRB1	3125	3125	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Three new DRB alleles routinely identified by sequence-based typing : DRB1 * 010103 , DRB1 * 0326 and DRB3 * 0219 .
15496209	0	DRB1	82,86	DRB1	69,73	DRB1	DRB1	3125	3125	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Three new DRB alleles routinely identified by sequence-based typing : DRB1 * 010103 , DRB1 * 0326 and DRB3 * 0219 .
21299540	0	DRB1	105,109	DRB1	90,94	DRB1	DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
21299540	0	DRB1	129,133	DRB1	142,146	DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
21299540	0	DRB1	142,146	DRB1	129,133	DRB1	DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
21299540	0	DRB1	90,94	DRB1	105,109	DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
24103044	0	DRB1	24,28	DRB1	39,43	DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Four novel HLA alleles , DRB1 * 04:11:03 , DRB1 * 10:05 , DRB1 * 15:94 and DRB1 * 16:22 , identified in Brazilian individuals .
24103044	0	DRB1	39,43	DRB1	24,28	DRB1	DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Four novel HLA alleles , DRB1 * 04:11:03 , DRB1 * 10:05 , DRB1 * 15:94 and DRB1 * 16:22 , identified in Brazilian individuals .
7652736	0	DRB1	121,125	DRB1	132,136	DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Direct sequencing of SSP-PCR-amplified cDNA to identify new alleles in the DR52-associated DRB1 group : identification of DRB1 * 1115 , DRB1 * 1117 and DRB1 * 1319 .
7652736	0	DRB1	132,136	DRB1	121,125	DRB1	DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Direct sequencing of SSP-PCR-amplified cDNA to identify new alleles in the DR52-associated DRB1 group : identification of DRB1 * 1115 , DRB1 * 1117 and DRB1 * 1319 .
10519372	0	DRB1	91,95	HLA-B	79,84	DRB1	HLA-B	3125	3106	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	HLA-Cw * 1701 is associated with two sub-Saharan African-derived HLA haplotypes : HLA-B * 4201 , DRB1 * 03 and HLA-B * 4202 without DRB1 * 03 .
10958361	0	DRB1	49,53	HLA-DRB1	34,42	DRB1	HLA-DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Identification of two new alleles HLA-DRB1 * 0312 , DRB1 * 0432 and of a DRB3-negative DRB1 * 1313-positive haplotype .
11169267	0	DRB1	13,17	HLA-DRB1	0,8	DRB1	HLA-DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	HLA-DRB1 * 03 , DRB1 * 11 or DRB1 * 12 and their respective DRB3 specificities in clinical variants of sarcoidosis .
15719619	0	DRB1	36,40	HLA-DRB1	21,29	DRB1	HLA-DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Relationship between HLA-DRB1 * 0101 , DRB1 * 0301 alleles and interleukin-12 in haemophilic patients and hepatitis_C_virus_positive_hepatocellular_carcinoma patients .
17284220	0	DRB1	48,52	HLA-DRB1	28,36	DRB1	HLA-DRB1	3123	3123	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a novel HLA-DRB1 * 04 allele -LRB- DRB1 * 0460 -RRB- in the Italian population .
21299540	0	DRB1	63,67	HLA-DRB1	47,55	DRB1	HLA-DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
21299540	0	DRB1	75,79	HLA-DRB1	47,55	DRB1	HLA-DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
22803809	0	DRB1	46,50	HLA-DRB1	24,32	DRB1	HLA-DRB1	3123	3123	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-DRB1 * 16 variant , DRB1 * 16:19 by sequence-based typing in a Chinese Han .
26467900	0	DRB1	25,29	HLA-DRB1	8,16	DRB1	HLA-DRB1	3123	3123	Gene	Gene	*|dep|START_ENTITY *|compound|END_ENTITY	A novel HLA-DRB1 allele , DRB1 * 16:36 identified in a Chinese individual from the Xinjiang region .
26812063	0	DRB1	25,29	HLA-DRB1	8,16	DRB1	HLA-DRB1	3123	3123	Gene	Gene	*|dep|START_ENTITY *|compound|END_ENTITY	A novel HLA-DRB1 allele , DRB1 * 15:66:02 was identified in a Chinese potential donor by sequence-based typing .
25417716	0	DRB1	27,31	MPK3	96,100	DRB1	MPK3	837498(Tax:3702)	823706(Tax:3702)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MicroRNA biogenesis factor DRB1 is a phosphorylation target of mitogen activated protein kinase MPK3 in both rice and Arabidopsis .
23283466	0	DRB1	58,62	leukocyte_antigen_class_II	30,56	DRB1	leukocyte antigen class II	3123	3127	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Association analysis of human leukocyte_antigen_class_II -LRB- DRB1 -RRB- alleles with leprosy in individuals from S o Lu s , state of Maranh o , Brazil .
21987769	0	DRBP76	0,6	VP35	35,39	DRBP76	VP35	3609	911827(Tax:186538)	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function .
12488059	0	DRD1	58,62	dopamine_D1_receptor	31,51	DRD1	dopamine D1 receptor	1812	1812	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Linkage disequilibrium between dopamine_D1_receptor gene -LRB- DRD1 -RRB- and bipolar_disorder .
21181138	0	DRD1	60,64	dopamine_D1_receptor	38,58	DRD1	dopamine D1 receptor	1812	1812	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of genetic variations in the dopamine_D1_receptor -LRB- DRD1 -RRB- gene and antipsychotics-induced tardive_dyskinesia in schizophrenia .
8837716	0	DRD1	98,102	dopamine_D1_receptor	76,96	DRD1	dopamine D1 receptor	1812	1812	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Systematic screening for mutations in the 5 ' - regulatory region of the human dopamine_D1_receptor -LRB- DRD1 -RRB- gene in patients with schizophrenia and bipolar_affective_disorder .
17310237	0	DRD1	46,50	dopamine_receptor_D1	19,39	DRD1	dopamine receptor D1	1812	1812	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the dopamine_receptor_D1 gene , DRD1 , with inattention symptoms in families selected for reading problems .
15318112	0	DRD2	18,22	ADH1C	9,14	DRD2	ADH1C	1813	126	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	ADH1B * 1 , ADH1C * 2 , DRD2 -LRB- -141 C Ins -RRB- , and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles .
20150882	0	DRD2	54,58	ANKK1	47,52	DRD2	ANKK1	1813	255239	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The association between TaqI A polymorphism of ANKK1 -LRB- DRD2 -RRB- gene and ADHD in the Czech boys aged between 6 and 13 years .
16766132	0	DRD2	94,98	D2_dopamine_receptor	72,92	DRD2	D2 dopamine receptor	1813	1813	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Heavy nicotine and alcohol use in alcohol dependence is associated with D2_dopamine_receptor -LRB- DRD2 -RRB- polymorphism .
17615493	0	DRD2	22,26	D2_dopamine_receptor	0,20	DRD2	D2 dopamine receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	D2_dopamine_receptor -LRB- DRD2 -RRB- gene Taq1A polymorphism and the eating-related psychological_traits_in_eating_disorders -LRB- anorexia_nervosa_and_bulimia -RRB- and obesity .
11236830	0	DRD2	27,31	Dopamine_D2_receptor	0,20	DRD2	Dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_D2_receptor gene -LRB- DRD2 -RRB- is associated with alcoholism with conduct_disorder .
7647164	0	DRD2	27,31	Dopamine_D2_receptor	0,20	DRD2	Dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_D2_receptor gene -LRB- DRD2 -RRB- haplotypes and the defense style questionnaire in substance_abuse , Tourette_syndrome , and controls .
8874837	0	DRD2	22,26	Dopamine_D2_receptor	0,20	DRD2	Dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_D2_receptor -LRB- DRD2 -RRB- gene and susceptibility to posttraumatic_stress_disorder : a study and replication .
8972908	0	DRD2	27,31	Dopamine_D2_receptor	0,20	DRD2	Dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_D2_receptor gene -LRB- DRD2 -RRB- haplotypes in Caucasians .
24951719	0	DRD2	78,82	OPRM1	45,50	DRD2	OPRM1	1813	4988	Gene	Gene	Receptor|appos|START_ENTITY Receptor|appos|END_ENTITY	Genetic Variation of the Mu Opioid Receptor -LRB- OPRM1 -RRB- and Dopamine_D2_Receptor -LRB- DRD2 -RRB- is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar_Disorder .
11261743	0	DRD2	50,54	dopamine_D2_receptor	23,43	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between dopamine_D2_receptor gene -LRB- DRD2 -RRB- and human intelligence .
11353448	0	DRD2	50,54	dopamine_D2_receptor	28,48	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Relationship between Taq1 A dopamine_D2_receptor -LRB- DRD2 -RRB- polymorphism and prolactin response to bromperidol .
1351040	0	DRD2	57,61	dopamine_D2_receptor	30,50	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A rare FokI RFLP in the human dopamine_D2_receptor gene -LRB- DRD2 -RRB- .
18821566	0	DRD2	35,39	dopamine_D2_receptor	8,28	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SNPs in dopamine_D2_receptor gene -LRB- DRD2 -RRB- and norepinephrine_transporter gene -LRB- NET -RRB- are associated with continuous performance task -LRB- CPT -RRB- phenotypes in ADHD children and their families .
22521396	0	DRD2	46,50	dopamine_D2_receptor	24,44	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between the dopamine_D2_receptor -LRB- DRD2 -RRB- polymorphism and the personality traits of healthy Japanese participants .
22536882	0	DRD2	34,38	dopamine_D2_receptor	12,32	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of dopamine_D2_receptor -LRB- DRD2 -RRB- gene polymorphisms in cannabinoid addicts .
22798433	0	DRD2	119,123	dopamine_D2_receptor	92,112	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The moderating effect of alcohol-specific parental rule-setting on the relation between the dopamine_D2_receptor gene -LRB- DRD2 -RRB- , the - opioid receptor gene -LRB- OPRM1 -RRB- and alcohol use in young adolescents .
24157248	0	DRD2	41,45	dopamine_D2_receptor	19,39	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Methylation of the dopamine_D2_receptor -LRB- DRD2 -RRB- gene promoter in women with a bulimia-spectrum_disorder : associations with borderline_personality_disorder and exposure to childhood abuse .
24469773	0	DRD2	60,64	dopamine_D2_receptor	38,58	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Assessment of association between the dopamine_D2_receptor -LRB- DRD2 -RRB- polymorphism and neurodevelopment of children exposed to lead .
24634060	0	DRD2	118,122	dopamine_D2_receptor	91,111	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Altered regional brain volumes in elderly carriers of a risk variant for drug_abuse in the dopamine_D2_receptor gene -LRB- DRD2 -RRB- .
8679787	0	DRD2	95,99	dopamine_D2_receptor	68,88	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between alcoholism and multiple polymorphisms at the dopamine_D2_receptor gene -LRB- DRD2 -RRB- in three distinct Taiwanese populations .
8845863	0	DRD2	26,30	dopamine_D2_receptor	4,24	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The dopamine_D2_receptor -LRB- DRD2 -RRB- gene : a genetic risk factor in smoking .
9118359	0	DRD2	167,171	dopamine_D2_receptor	145,165	DRD2	dopamine D2 receptor	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variants of the human obesity -LRB- OB -RRB- gene : association with body mass index in young women , psychiatric symptoms , and interaction with the dopamine_D2_receptor -LRB- DRD2 -RRB- gene .
25761959	0	DRD2	52,56	dopamine_receptor_D2	30,50	DRD2	dopamine receptor D2	1813	1813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The C957T polymorphism in the dopamine_receptor_D2 -LRB- DRD2 -RRB- gene modulates domain-general category learning .
24926820	0	DRD2	44,48	dopamine_receptor_type-2	18,42	DRD2	dopamine receptor type-2	1813	1813	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Activation of the dopamine_receptor_type-2 -LRB- DRD2 -RRB- promoter by 9-cis retinoic_acid in a cellular model of Cushing 's _ disease mediates the inhibition of cell proliferation and ACTH secretion without a complete corticotroph-to-melanotroph transdifferentiation .
11673801	0	DRD3	22,26	D3_receptor	9,20	DRD3	D3 receptor	1814	1814	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Dopamine D3_receptor -LRB- DRD3 -RRB- gene polymorphism is associated with the intensity of eye movement_disturbances in schizophrenic patients and healthy subjects .
19503018	0	DRD3	72,76	dopamine_D3_receptor	50,70	DRD3	dopamine D3 receptor	1814	1814	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis between polymorphisms in the dopamine_D3_receptor -LRB- DRD3 -RRB- gene and cocaine_dependence .
19897343	0	DRD3	26,30	dopamine_D3_receptor	4,24	DRD3	dopamine D3 receptor	1814	1814	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The dopamine_D3_receptor -LRB- DRD3 -RRB- gene and risk of schizophrenia : case-control studies and an updated meta-analysis .
9491816	0	DRD3	26,30	dopamine_D3_receptor	4,24	DRD3	dopamine D3 receptor	1814	1814	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The dopamine_D3_receptor -LRB- DRD3 -RRB- Ser9Gly polymorphism and schizophrenia : a haplotype relative risk study and association with clozapine response .
22931814	0	DRD4	26,30	5-HTTLPR	16,24	DRD4	5-HTTLPR	1815	6532	Gene	Gene	polymorphisms|nummod|START_ENTITY END_ENTITY|appos|polymorphisms	-LSB- Association of 5-HTTLPR , DRD4 gene polymorphisms with the accident tendentiousness of drivers -RSB- .
7944879	0	DRD4	47,51	D4_dopamine_receptor	25,45	DRD4	D4 dopamine receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic variation in the D4_dopamine_receptor -LRB- DRD4 -RRB- gene does not predict response to clozapine .
10898909	0	DRD4	36,40	DAT	68,71	DRD4	DAT	1815	6531	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Investigation of dopamine receptor -LRB- DRD4 -RRB- and dopamine_transporter -LRB- DAT -RRB- polymorphisms for genetic linkage or association to panic_disorder .
24747168	0	DRD4	31,35	Dopamine_D4_Receptor	4,24	DRD4	Dopamine D4 Receptor	1815	1815	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	The Dopamine_D4_Receptor Gene -LRB- DRD4 -RRB- Moderates Cultural Difference in Independent Versus Interdependent Social Orientation .
11126393	0	DRD4	22,26	Dopamine_D4_receptor	0,20	DRD4	Dopamine D4 receptor	1815	1815	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Dopamine_D4_receptor -LRB- DRD4 -RRB- gene polymorphism is associated with attachment disorganization in infants .
11354829	0	DRD4	22,26	Dopamine_D4_receptor	0,20	DRD4	Dopamine D4 receptor	1815	1815	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Dopamine_D4_receptor -LRB- DRD4 -RRB- polymorphism and adaptability trait during infancy : a longitudinal study in 1 - to 5-month-old neonates .
15578612	0	DRD4	22,26	Dopamine_receptor_D4	0,20	DRD4	Dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_receptor_D4 -LRB- DRD4 -RRB- gene in Han Chinese children with attention-deficit/hyperactivity _ disorder -LRB- ADHD -RRB- : increased prevalence of the 2-repeat allele .
10570917	0	DRD4	78,82	dopamine_D4_receptor	56,76	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel polymorphisms in the upstream region of the human dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
10581493	0	DRD4	75,79	dopamine_D4_receptor	48,68	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tandem duplication polymorphism upstream of the dopamine_D4_receptor gene -LRB- DRD4 -RRB- .
10750051	0	DRD4	49,53	dopamine_D4_receptor	27,47	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evolution of exon 1 of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene in primates .
10898895	0	DRD4	61,65	dopamine_D4_receptor	39,59	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	A haplotype relative risk study of the dopamine_D4_receptor -LRB- DRD4 -RRB- exon III repeat polymorphism and attention deficit_hyperactivity_disorder -LRB- ADHD -RRB- .
11032387	0	DRD4	101,105	dopamine_D4_receptor	74,94	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine_D4_receptor gene -LRB- DRD4 -RRB- with attention_deficit_hyperactivity_disorder -LRB- ADHD -RRB- .
11358133	0	DRD4	95,99	dopamine_D4_receptor	73,93	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genotyping the -521 C/T functional polymorphism in the promoter region of dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
11583250	0	DRD4	50,54	dopamine_D4_receptor	23,43	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association of the dopamine_D4_receptor gene -LRB- DRD4 -RRB- and the serotonin transporter promoter gene -LRB- 5-HTTLPR -RRB- with temperament in 12-month-old infants .
11803443	0	DRD4	59,63	dopamine_D4_receptor	37,57	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Further evidence for the role of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene in attachment disorganization : interaction of the exon III 48-bp repeat and the -521 _ C/T promoter polymorphisms .
12116162	0	DRD4	111,115	dopamine_D4_receptor	89,109	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Direct haplotype detection of adjacent polymorphic sites in the regulatory region of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
14755455	0	DRD4	71,75	dopamine_D4_receptor	49,69	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	A dyslexia susceptibility locus -LRB- DYX7 -RRB- linked to dopamine_D4_receptor -LRB- DRD4 -RRB- region on chromosome 11p15 .5 .
15078164	0	DRD4	132,136	dopamine_D4_receptor	110,130	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Capillary electrophoresis study on DNA-protein complex formation in the polymorphic 5 ' upstream region of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
15206004	0	DRD4	37,41	dopamine_D4_receptor	15,35	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of dopamine_D4_receptor -LRB- DRD4 -RRB- gene with attention-deficit/hyperactivity _ disorder -LRB- ADHD -RRB- in a high-risk community sample : a longitudinal study from birth to 11 years of age .
16619053	0	DRD4	48,52	dopamine_D4_receptor	21,41	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the dopamine_D4_receptor gene -LRB- DRD4 -RRB- contribute to individual differences in human sexual_behavior : desire , arousal and sexual function .
16815339	0	DRD4	42,46	dopamine_D4_receptor	20,40	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between dopamine_D4_receptor -LRB- DRD4 -RRB- gene polymorphisms and novelty-elicited auditory event-related potentials in preschool children .
16917940	0	DRD4	46,50	dopamine_D4_receptor	24,44	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exon 3 polymorphisms of dopamine_D4_receptor -LRB- DRD4 -RRB- gene and attention_deficit_hyperactivity_disorder in Chinese children .
17028370	4	DRD4	511,515	dopamine_D4_receptor	489,509	DAT1	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	We highlight the two most prominent findings with the dopamine_D4_receptor -LRB- DRD4 -RRB- gene and the dopamine_transporter -LRB- DAT1 -RRB- gene , and their implications for the understanding of the cellular and neurobiological basis for ADHD .
17387332	0	DRD4	47,51	dopamine_D4_receptor	25,45	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the dopamine_D4_receptor -LRB- DRD4 -RRB- gene and smoking cessation : follow-up of a randomised clinical trial of transdermal nicotine patch .
17474081	0	DRD4	51,55	dopamine_D4_receptor	24,44	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novelty seeking and the dopamine_D4_receptor gene -LRB- DRD4 -RRB- revisited in Asians : haplotype characterization and relevance of the 2-repeat allele .
17574217	0	DRD4	41,45	dopamine_D4_receptor	19,39	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene and approach-related personality traits : meta-analysis and new data .
18331372	0	DRD4	70,74	dopamine_D4_receptor	48,68	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Smoking status moderates the association of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene VNTR polymorphism with selective processing of smoking-related cues .
19602428	0	DRD4	52,56	dopamine_D4_receptor	30,50	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Minor genetic variants of the dopamine_D4_receptor -LRB- DRD4 -RRB- polymorphism are associated with novelty seeking in healthy Japanese subjects .
22198971	0	DRD4	105,109	dopamine_D4_receptor	83,103	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Religion priming differentially increases prosocial behavior among variants of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
22564179	0	DRD4	144,148	dopamine_D4_receptor	117,137	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Double dissociation between lab measures of inattention and impulsivity and the dopamine_transporter gene -LRB- DAT1 -RRB- and dopamine_D4_receptor gene -LRB- DRD4 -RRB- .
24102377	0	DRD4	115,119	dopamine_D4_receptor	93,113	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mothers ' prenatal stress and their children 's antisocial outcomes -- a moderating role for the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
7831304	0	DRD4	37,41	dopamine_D4_receptor	15,35	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variability of dopamine_D4_receptor -LRB- DRD4 -RRB- gene sequence within and among nonhuman primate species .
8723054	0	DRD4	54,58	dopamine_D4_receptor	32,52	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of imprinting of the human dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
9034534	0	DRD4	31,35	dopamine_D4_receptor	4,24	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The dopamine_D4_receptor gene -LRB- DRD4 -RRB- is not associated with alcoholism in three Taiwanese populations : six polymorphisms tested separately and as haplotypes .
9711064	0	DRD4	73,77	dopamine_D4_receptor	51,71	DRD4	dopamine D4 receptor	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparison of a hypervariable segment in the human dopamine_D4_receptor -LRB- DRD4 -RRB- gene between the Japanese and Mongolian populations .
12497615	0	DRD4	46,50	dopamine_receptor_D4	24,44	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Association between the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene and obsessive-compulsive_disorder .
15077199	0	DRD4	73,77	dopamine_receptor_D4	51,71	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The genetic architecture of selection at the human dopamine_receptor_D4 -LRB- DRD4 -RRB- gene locus .
16332176	0	DRD4	91,95	dopamine_receptor_D4	69,89	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Identification and characterization of tandem repeats in exon III of dopamine_receptor_D4 -LRB- DRD4 -RRB- genes from different mammalian species .
16495430	0	DRD4	96,100	dopamine_receptor_D4	74,94	DRD4	dopamine receptor D4	101906668	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of a tandem repeat in exon III of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene in cetaceans .
16887146	0	DRD4	52,56	dopamine_receptor_D4	25,45	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic structure of the dopamine_receptor_D4 gene -LRB- DRD4 -RRB- and lack of association with schizophrenia in Japanese patients .
19713452	0	DRD4	103,107	dopamine_receptor_D4	81,101	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assortative human pair-bonding for partner ancestry and allelic variation of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene .
20359751	0	DRD4	73,77	dopamine_receptor_D4	51,71	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association of exon 3 VNTR polymorphism of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene with alcoholism in Mexican Americans .
20644990	0	DRD4	31,35	dopamine_receptor_D4	4,24	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The dopamine_receptor_D4 gene -LRB- DRD4 -RRB- moderates family environmental effects on ADHD .
23986684	0	DRD4	89,93	dopamine_receptor_D4	62,82	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association between creativity and 7R polymorphism in the dopamine_receptor_D4 gene -LRB- DRD4 -RRB- .
8353495	0	DRD4	59,63	dopamine_receptor_D4	37,57	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A hypervariable segment in the human dopamine_receptor_D4 -LRB- DRD4 -RRB- gene .
9491811	0	DRD4	41,45	dopamine_receptor_D4	19,39	DRD4	dopamine receptor D4	1815	1815	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene with a refined phenotype of attention_deficit_hyperactivity_disorder -LRB- ADHD -RRB- : a family-based approach .
11304828	0	DRD5	48,52	dopamine_D5_receptor	21,41	DRD5	dopamine D5 receptor	1816	1816	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Markers close to the dopamine_D5_receptor gene -LRB- DRD5 -RRB- show significant association with schizophrenia but not bipolar_disorder .
12700316	0	DRD5	34,38	dopamine_D5_receptor	12,32	DRD5	dopamine D5 receptor	1816	1816	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the dopamine_D5_receptor -LRB- DRD5 -RRB- as a susceptibility gene for cervical dystonia .
14755441	0	DRD5	43,47	dopamine_D5_receptor	21,41	DRD5	dopamine D5 receptor	1816	1816	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the dopamine_D5_receptor -LRB- DRD5 -RRB- gene and ADHD .
24487321	0	DREAM	25,30	A20	60,63	DREAM	A20	56461(Tax:10090)	21929(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation .
24857398	0	DREAM	14,19	Downstream_Regulatory_Element_Antagonistic_Modulator	21,73	DREAM	Downstream Regulatory Element Antagonistic Modulator	56461(Tax:10090)	56461(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of DREAM -LRB- Downstream_Regulatory_Element_Antagonistic_Modulator -RRB- , a Calcium-Binding Protein , Reduces L-DOPA-Induced Dyskinesias in Mice .
22901871	0	DREAM	35,40	IL-5	10,14	DREAM	IL-5	30818	3567	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting IL-5 in severe asthma : a DREAM come true ?
23667535	0	DREAM	23,28	LIN9	0,4	DREAM	LIN9	30818	286826	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex END_ENTITY|appos|subunit	LIN9 , a subunit of the DREAM complex , regulates mitotic gene expression and proliferation of embryonic stem cells .
20404087	0	DREAM	33,38	Lin9	0,4	DREAM	Lin9	30818	286826	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex END_ENTITY|appos|subunit	Lin9 , a subunit of the mammalian DREAM complex , is essential for embryonic development , for survival of adult mice , and for tumor suppression .
19238593	0	DREAM	19,24	PACAP	0,5	DREAM	PACAP	30818	116	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	PACAP signaling to DREAM : a cAMP-dependent pathway that regulates cortical astrogliogenesis .
17562172	0	DREAM	68,73	downstream_regulatory_element_antagonist_modulator	16,66	DREAM	downstream regulatory element antagonist modulator	65199(Tax:10116)	65199(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of downstream_regulatory_element_antagonist_modulator -LRB- DREAM -RRB- in rat spinal cord and upregulation of its expression during inflammatory pain .
20395451	0	DREB2C	0,6	ABF2	22,26	DREB2C	ABF2	818627(Tax:3702)	841095(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DREB2C interacts with ABF2 , a bZIP protein regulating abscisic_acid-responsive gene expression , and its overexpression affects abscisic_acid sensitivity .
20849812	0	DREB2C	12,18	HsfA3	63,68	DREB2C	HsfA3	818627(Tax:3702)	831749(Tax:3702)	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	Arabidopsis DREB2C functions as a transcriptional activator of HsfA3 during the heat_stress response .
19032147	0	DREF	30,34	DmTTF	125,130	DREF	DmTTF	34328(Tax:7227)	34837(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial_transcription_termination_factor DmTTF .
15461664	0	DREF	0,4	EGFR	21,25	DREF	EGFR	34328(Tax:7227)	37455(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	DREF is required for EGFR signalling during Drosophila wing vein development .
16629902	0	DREF	64,68	PCNA	42,46	DREF	PCNA	34328(Tax:7227)	37290(Tax:7227)	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Antagonistic regulation of the Drosophila PCNA gene promoter by DREF and Cut .
12459787	0	DREF	21,25	TRF2	0,4	DREF	TRF2	34328(Tax:7227)	31773(Tax:7227)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila .
23916463	0	DREF	26,30	mitochondrial_DNA_helicase	63,89	DREF	mitochondrial DNA helicase	34328(Tax:7227)	34307(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Drosophila nuclear factor DREF regulates the expression of the mitochondrial_DNA_helicase and mitochondrial_transcription_factor_B2 but not the mitochondrial_translation_factor_B1 .
20101238	0	DREF	8,12	p53	61,64	DREF	p53	34328(Tax:7227)	2768677(Tax:7227)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of DREF in transcriptional regulation of the Drosophila p53 gene .
12045184	0	DRONC	43,48	Broad-Complex	126,139	DRONC	Broad-Complex	39173(Tax:7227)	44505(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex .
10675329	0	DRONC	23,28	DIAP1	45,50	DRONC	DIAP1	39173(Tax:7227)	39753(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The Drosophila caspase DRONC is regulated by DIAP1 .
12397080	0	DRONC	131,136	DIAP1	15,20	DRONC	DIAP1	39173(Tax:7227)	39753(Tax:7227)	Gene	Gene	form|nmod|START_ENTITY accumulation|nmod|form prevent|dobj|accumulation required|xcomp|prevent required|nsubjpass|protein protein|compound|END_ENTITY	The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated , processed form of the apical caspase DRONC .
26147304	0	DROSHA	50,56	DICER1	58,64	DROSHA	DICER1	29102	23405	Gene	Gene	Associated|nmod|START_ENTITY Associated|nsubj|END_ENTITY	3 ' - UTR Polymorphisms in the MiRNA Machinery Genes DROSHA , DICER1 , RAN , and XPO5 Are Associated with Colorectal_Cancer Risk in a Korean Population .
10574455	0	DRP-2	69,74	dihydropyrimidinase-related_protein_2	30,67	DRP-2	dihydropyrimidinase-related protein 2	1821	1821	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the human dihydropyrimidinase-related_protein_2 -LRB- DRP-2 -RRB- gene .
12951196	0	DRP-2	66,71	dihydropyrimidinase-related_protein_2	27,64	DRP-2	dihydropyrimidinase-related protein 2	1821	1821	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between the dihydropyrimidinase-related_protein_2 -LRB- DRP-2 -RRB- gene and bipolar_disorder in humans .
15027329	0	DRP-2	50,55	dihydropyrimidinase-related_protein_2	11,48	DRP-2	dihydropyrimidinase-related protein 2	1821	1821	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The human dihydropyrimidinase-related_protein_2 -LRB- DRP-2 -RRB- gene on chromosome 8p21 is associated with paranoid-type_schizophrenia -RSB- .
9712324	0	DRP-3	76,81	dihydropyrimidinase-related_protein_3	37,74	DRP-3	dihydropyrimidinase-related protein 3	22240(Tax:10090)	22240(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Post-meiotic expression of the mouse dihydropyrimidinase-related_protein_3 -LRB- DRP-3 -RRB- gene during spermiogenesis .
8640231	0	DRP2	20,24	dystrophin	40,50	DRP2	dystrophin	1821	1756	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of DRP2 , a novel human dystrophin homologue .
11083927	0	DRP2	45,49	dystrophin-related_protein_2	15,43	DRP2	dystrophin-related protein 2	66027(Tax:10116)	66027(Tax:10116)	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of dystrophin-related_protein_2 -LRB- DRP2 -RRB- with postsynaptic densities in rat brain .
23046048	0	DRP3A	59,64	DRP3B	66,71	DRP3A	DRP3B	829506(Tax:3702)	815898(Tax:3702)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Differential roles of Arabidopsis dynamin-related proteins DRP3A , DRP3B , and DRP5B in organelle division .
19816122	0	DRP3A	95,100	DYNAMIN-RELATED_PROTEIN3A	68,93	DRP3A	DYNAMIN-RELATED PROTEIN3A	829506(Tax:3702)	829506(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Arabidopsis peroxisome division mutant pdd2 is defective in the DYNAMIN-RELATED_PROTEIN3A -LRB- DRP3A -RRB- gene .
23046048	0	DRP3B	66,71	DRP3A	59,64	DRP3B	DRP3A	815898(Tax:3702)	829506(Tax:3702)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Differential roles of Arabidopsis dynamin-related proteins DRP3A , DRP3B , and DRP5B in organelle division .
8965642	0	DRPLA	0,5	atrophin-1	12,22	DRPLA	atrophin-1	1822	1822	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	DRPLA gene -LRB- atrophin-1 -RRB- sequence and mRNA expression in human brain .
11042112	0	DRPLA	66,71	dentatorubral-pallidoluysian_atrophy	28,64	DRPLA	dentatorubral-pallidoluysian atrophy	1822	1822	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Aberrant phosphorylation of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein complex in brain tissue .
12235796	0	DRPLA	84,89	dentatorubral-pallidoluysian_atrophy	46,82	DRPLA	dentatorubral-pallidoluysian atrophy	13498(Tax:10090)	13498(Tax:10090)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Molecular mechanisms of neurodegeneration in dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- -RSB- .
9109905	0	DRPLA	106,111	dentatorubral-pallidoluysian_atrophy	68,104	DRPLA	dentatorubral-pallidoluysian atrophy	1822	1822	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Homozygosity for an allele carrying intermediate CAG repeats in the dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- gene results in spastic_paraplegia .
9143016	0	DRPLA	52,57	dentatorubral-pallidoluysian_atrophy	14,50	DRPLA	dentatorubral-pallidoluysian atrophy	1822	1822	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Expression of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- proteins in patients .
9705838	0	DRPLA	75,80	dentatorubral-pallidoluysian_atrophy	37,73	DRPLA	dentatorubral-pallidoluysian atrophy	1822	1822	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Intracellular aggregate formation of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein with the extended polyglutamine .
9735324	0	DRPLA	94,99	dentatorubral-pallidoluysian_atrophy	56,92	DRPLA	dentatorubral-pallidoluysian atrophy	1822	1822	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expanded glutamine repeat enhances complex formation of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein in human brains .
9878517	0	DRPLA	70,75	dentatorubral-pallidoluysian_atrophy	32,68	DRPLA	dentatorubral-pallidoluysian atrophy	1822	29515(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Different complex formations of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein in human and rat neurons .
8825056	0	DRPLA	133,138	dentatorubral_pallidoluysian_atrophy	95,131	DRPLA	dentatorubral pallidoluysian atrophy	1822	1822	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Benign adult familial myoclonus_epilepsy -LRB- BAFME -RRB- : an autosomal dominant form not linked to the dentatorubral_pallidoluysian_atrophy -LRB- DRPLA -RRB- gene .
17523919	0	DRR1	28,32	down-regulated_in_renal_cell_carcinoma_1	34,74	DRR1	down-regulated in renal cell carcinoma 1	11170	11170	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Soluble expression of human DRR1 -LRB- down-regulated_in_renal_cell_carcinoma_1 -RRB- in Escherichia_coli and preparation of its polyclonal antibodies .
12568728	0	DRRF	102,106	dopamine_receptor_regulating_factor	65,100	DRRF	dopamine receptor regulating factor	118445(Tax:10090)	118445(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and promoter characterization of the murine dopamine_receptor_regulating_factor -LRB- DRRF -RRB- gene .
18472212	0	DRRF	76,80	dopamine_receptor_regulating_factor	39,74	DRRF	dopamine receptor regulating factor	118445(Tax:10090)	118445(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional auto-regulation of the dopamine_receptor_regulating_factor -LRB- DRRF -RRB- gene .
20599935	0	DRb1	0,4	DQb1	11,15	DRb1	DQb1	3123	3119	Gene	Gene	*|nsubj|START_ENTITY *|dobj|1501 1501|appos|END_ENTITY	DRb1 * 1501 , DQb1 * 0602 donor allelic haplotype and humoral antibody episodes of acute renal allograft rejection .
19765682	0	DSC3	59,63	desmocollin-3	44,57	DSC3	desmocollin-3	1825	1825	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A homozygous nonsense mutation in the human desmocollin-3 -LRB- DSC3 -RRB- gene underlies hereditary_hypotrichosis and recurrent skin_vesicles .
21364582	0	DSC3	0,4	p53	32,35	DSC3	p53	1825	7157	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	DSC3 expression is regulated by p53 , and methylation of DSC3 DNA is a prognostic marker in human colorectal_cancer .
23479427	0	DSCAM	20,25	AMPK	0,4	DSCAM	AMPK	1826	5563	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth .
18197079	0	DSCAM	68,73	Down_syndrome_cell_adhesion_molecule	30,66	DSCAM	Down syndrome cell adhesion molecule	1826	1826	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association study between the Down_syndrome_cell_adhesion_molecule -LRB- DSCAM -RRB- gene and bipolar_disorder .
16231093	0	DSCR1	22,27	Adapt78	29,36	DSCR1	Adapt78	1827	1827	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiple roles of the DSCR1 -LRB- Adapt78 or RCAN1 -RRB- gene and its protein product calcipressin 1 -LRB- or RCAN1 -RRB- in disease .
9325060	0	DSCR1	75,80	Down_syndrome_candidate_region_1	82,114	DSCR1	Down syndrome candidate region 1	1827	1827	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization , alternative splicing , and expression patterns of the DSCR1 -LRB- Down_syndrome_candidate_region_1 -RRB- gene .
22863780	0	DSCR1	0,5	FMRP	21,25	DSCR1	FMRP	1827	2332	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis .
22909818	0	DSCR1	14,19	FMRP	77,81	DSCR1	FMRP	1827	2332	Gene	Gene	causes|compound|START_ENTITY END_ENTITY|nmod|causes	Down syndrome DSCR1 causes spine pathology via the Fragile X-related protein FMRP .
18485347	0	DSCR1	16,21	RCAN1	23,28	DSCR1	RCAN1	54720(Tax:10090)	54720(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of DSCR1 -LRB- RCAN1 or Adapt78 -RRB- in the peri-infarct cortex after experimental stroke .
14718387	0	DSCR1	0,5	SOD1	39,43	DSCR1	SOD1	1827	6647	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	DSCR1 -LRB- Adapt78 -RRB- modulates expression of SOD1 .
15016650	0	DSCR1	41,46	VEGF	57,61	DSCR1	VEGF	1827	7422	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Down_syndrome_critical_region_protein_1 -LRB- DSCR1 -RRB- , a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells .
16516408	0	DSCR1L2	71,78	Down_syndrome_critical_region_gene_1-like_2	26,69	DSCR1L2	Down syndrome critical region gene 1-like 2	11123	11123	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Proteins encoded by human Down_syndrome_critical_region_gene_1-like_2 -LRB- DSCR1L2 -RRB- mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I -LRB- TNNI3 -RRB- .
18022329	0	DSCR1L2	44,51	RCAN3	37,42	DSCR1L2	RCAN3	11123	11123	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Identification and analysis of human RCAN3 -LRB- DSCR1L2 -RRB- mRNA and protein isoforms .
8941343	0	DSEB	80,84	differentiation-specific_element_binding_protein	30,78	DSEB	differentiation-specific element binding protein	19687(Tax:10090)	19687(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Antisense oligonucleotides to differentiation-specific_element_binding_protein -LRB- DSEB -RRB- mRNA inhibit adipocyte differentiation .
21495994	0	DSG4	91,95	desmoglein_4	77,89	DSG4	desmoglein 4	147409	147409	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein_4 -LRB- DSG4 -RRB- gene .
19389360	0	DSH-2	21,26	CWN-1	0,5	DSH-2	CWN-1	266854(Tax:6239)	173399(Tax:6239)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	CWN-1 functions with DSH-2 to regulate C. _ elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway .
9541230	0	DSPP	57,61	dentin_sialophosphoprotein	29,55	DSPP	dentin sialophosphoprotein	1834	1834	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Refined mapping of the human dentin_sialophosphoprotein -LRB- DSPP -RRB- gene within the critical dentinogenesis_imperfecta_type_II and dentin_dysplasia_type_II loci .
16086746	0	DSRAD	45,50	double-RNA-specific_adenosine_deaminase	4,43	DSRAD	double-RNA-specific adenosine deaminase	103	103	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The double-RNA-specific_adenosine_deaminase -LRB- DSRAD -RRB- gene in dyschromatosis symmetrica hereditaria patients : two novel mutations and one previously described .
15670828	0	DT-diaphorase	11,24	NQO1	26,30	DT-diaphorase	NQO1	1728	1728	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	No role of DT-diaphorase -LRB- NQO1 -RRB- in the protection against oxidized quercetin .
11241838	0	DTDST	60,65	SLC26A2	73,80	DTDST	SLC26A2	1836	1836	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Mutations in the diastrophic_dysplasia sulfate transporter -LRB- DTDST -RRB- gene -LRB- SLC26A2 -RRB- : 22 novel mutations , mutation review , associated skeletal phenotypes , and diagnostic relevance .
20369363	0	DTDST	33,38	SLC26A2	24,31	DTDST	SLC26A2	117267(Tax:10116)	117267(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Protein localization of SLC26A2 -LRB- DTDST -RRB- in rat kidney .
20592910	0	DTDST	122,127	SLC26A2	129,136	DTDST	SLC26A2	1836	1836	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Autosomal recessive multiple_epiphyseal_dysplasia in a Korean girl caused by novel compound heterozygous mutations in the DTDST -LRB- SLC26A2 -RRB- gene .
22553461	0	DTIS11	83,89	eyes_absent	11,22	DTIS11	eyes absent	32222(Tax:7227)	33916(Tax:7227)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Drosophila eyes_absent is a novel mRNA target of the tristetraprolin -LRB- TTP -RRB- protein DTIS11 .
20822372	0	DTNBP1	16,22	Dysbindin	0,9	DTNBP1	Dysbindin	84062	84062	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Dysbindin gene -LRB- DTNBP1 -RRB- in major depressive_disorder -LRB- MDD -RRB- patients : lack of association with clinical phenotypes .
21295953	0	DTNBP1	37,43	Dystrobrevin-binding_protein_1	0,30	DTNBP1	Dystrobrevin-binding protein 1	84062	84062	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dystrobrevin-binding_protein_1 gene -LRB- DTNBP1 -RRB- variants associated with cerebrospinal fluid homovanillic_acid and 5-hydroxyindoleacetic_acid concentrations in healthy volunteers .
22580710	0	DTNBP1	4,10	dysbindin-1	12,23	DTNBP1	dysbindin-1	84062	84062	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	The DTNBP1 -LRB- dysbindin-1 -RRB- gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans .
19621369	0	DTNBP1	46,52	dystrobrevin-binding_protein_1	14,44	DTNBP1	dystrobrevin-binding protein 1	84062	84062	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	The impact of dystrobrevin-binding_protein_1 -LRB- DTNBP1 -RRB- on neural correlates of episodic memory encoding and retrieval .
15066891	0	DTNBP1	122,128	dystrobrevin_binding_protein	87,115	DTNBP1	dystrobrevin binding protein	84062	84062	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin_binding_protein gene -LRB- DTNBP1 -RRB- .
12808430	0	DTNBP1	80,86	dystrobrevin_binding_protein_1	48,78	DTNBP1	dystrobrevin binding protein 1	84062	84062	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a high-risk haplotype for the dystrobrevin_binding_protein_1 -LRB- DTNBP1 -RRB- gene in the Irish study of high-density schizophrenia families .
15917270	0	DTNBP1	50,56	dystrobrevin_binding_protein_1	18,48	DTNBP1	dystrobrevin binding protein 1	84062	84062	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotypes at the dystrobrevin_binding_protein_1 -LRB- DTNBP1 -RRB- gene locus mediate risk for schizophrenia through reduced DTNBP1 expression .
17604607	0	DTNBP1	67,73	dystrobrevin_binding_protein_1	30,60	DTNBP1	dystrobrevin binding protein 1	84062	84062	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study between the dystrobrevin_binding_protein_1 gene -LRB- DTNBP1 -RRB- and schizophrenia : a meta-analysis .
19800201	0	DTNBP1	36,42	dystrobrevin_binding_protein_1	4,34	DTNBP1	dystrobrevin binding protein 1	84062	84062	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The dystrobrevin_binding_protein_1 -LRB- DTNBP1 -RRB- gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia -LRB- ICCSS -RRB- sample .
12198495	0	DTRAF1	44,50	JNK	88,91	DTRAF1	JNK	33638(Tax:7227)	44801(Tax:7227)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila .
25973305	0	DTWD1	57,62	Histone_deacetylase_3	0,21	DTWD1	Histone deacetylase 3	56986	8841	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Histone_deacetylase_3 inhibits new tumor suppressor gene DTWD1 in gastric_cancer .
11153911	0	DTX1	124,128	Deltex	116,122	DTX1	Deltex	1840	1840	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal localization , genomic characterization , and mapping to the Noonan_syndrome critical region of the human Deltex -LRB- DTX1 -RRB- gene .
9516435	0	DT_diaphorase	18,31	NQO1	33,37	DT diaphorase	NQO1	18104(Tax:10090)	18104(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Disruption of the DT_diaphorase -LRB- NQO1 -RRB- gene in mice leads to increased menadione toxicity .
10524205	0	DUB-1	111,116	interleukin-3	73,86	DUB-1	interleukin-3	13531(Tax:10090)	16187(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY element|nmod|gene element|amod|END_ENTITY	Analysis of cis-acting sequences and trans-acting factors regulating the interleukin-3 response element of the DUB-1 gene .
20947510	0	DUOX1	139,144	dual_oxidase_1	123,137	DUOX1	dual oxidase 1	171608(Tax:6239)	171608(Tax:6239)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis_elegans dual_oxidase_1 -LRB- DUOX1 -RRB- peroxidase domain .
18426362	0	DUOX2	60,65	dual_oxidase_2	44,58	DUOX2	dual oxidase 2	50506	50506	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel homozygous missense mutation of the dual_oxidase_2 -LRB- DUOX2 -RRB- gene in an adult patient with large goiter .
21565790	0	DUOX2	64,69	dual_oxidase_2	48,62	DUOX2	dual oxidase 2	50506	50506	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Identification and functional analysis of novel dual_oxidase_2 -LRB- DUOX2 -RRB- mutations in children with congenital_or_subclinical_hypothyroidism .
23457309	0	DUOX2	76,81	dual_oxidase_2	60,74	DUOX2	dual oxidase 2	50506	50506	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Congenital_hypothyroidism caused by a novel mutation of the dual_oxidase_2 -LRB- DUOX2 -RRB- gene .
24410844	0	DUOXA1	34,40	Dual_oxidase_maturation_factor_1	0,32	DUOXA1	Dual oxidase maturation factor 1	213696(Tax:10090)	213696(Tax:10090)	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Dual_oxidase_maturation_factor_1 -LRB- DUOXA1 -RRB- overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation .
18042646	0	DUOXA2	64,70	dual_oxidase_maturation_factor_2	30,62	DUOXA2	dual oxidase maturation factor 2	405753	405753	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Biallelic inactivation of the dual_oxidase_maturation_factor_2 -LRB- DUOXA2 -RRB- gene as a novel cause of congenital_hypothyroidism .
21317287	0	DUSP-4	45,51	dual_specific_phosphatase-4	16,43	DUSP-4	dual specific phosphatase-4	319520(Tax:10090)	319520(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion of the dual_specific_phosphatase-4 -LRB- DUSP-4 -RRB- gene reveals an essential non-redundant role for MAP kinase phosphatase-2 -LRB- MKP-2 -RRB- in proliferation and cell survival .
16081065	0	DUSP1	29,34	ERK	110,113	HIF-1	ERK	3091	5594	Gene	Gene	protects|nsubj|START_ENTITY protects|advcl|inactivating inactivating|dobj|MAPK MAPK|compound|END_ENTITY	Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible_factor_1 through inactivating ERK MAPK .
22897852	0	DUSP1	113,118	ERK	137,140	DUSP1	ERK	19252(Tax:10090)	26413(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Therapeutic effect of y-secretase inhibition in KrasG12V-driven non-small_cell_lung_carcinoma by derepression of DUSP1 and inhibition of ERK .
18403641	0	DUSP1	0,5	p53	23,26	DUSP1	p53	1843	7157	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	DUSP1 is controlled by p53 during the cellular response to oxidative stress .
26511729	0	DUSP5	88,93	MeCP2	0,5	DUSP5	MeCP2	1847	4204	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5 .
20097731	0	DUSP6	32,37	ERK	99,102	DUSP6	ERK	1848	5594	Gene	Gene	Dual_specificity_phosphatase_6|appos|START_ENTITY mediator|nsubj|Dual_specificity_phosphatase_6 mediator|nmod|END_ENTITY	Dual_specificity_phosphatase_6 -LRB- DUSP6 -RRB- is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung_cancer cells .
21680106	0	DUSP6	27,32	ERK	52,55	DUSP6	ERK	1848	5594	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Differential expression of DUSP6 with expression of ERK and Ki-67 in non-small_cell_lung_carcinoma .
22155192	0	DUSP6	27,32	ERK	73,76	DUSP6	ERK	1848	5594	Gene	Gene	association|nmod|START_ENTITY association|nmod|activity activity|compound|END_ENTITY	The genetic association of DUSP6 with bipolar_disorder and its effect on ERK activity .
26309510	0	DUSP6	82,87	MicroRNA-145	0,12	DUSP6	MicroRNA-145	1848	406937	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-145 inhibits human papillary cancer TPC1 cell proliferation by targeting DUSP6 .
21387288	0	DUSP6	49,54	dual-specificity_phosphatase	17,45	DUSP6	dual-specificity phosphatase	1848	1848	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Tumor suppressor dual-specificity_phosphatase 6 -LRB- DUSP6 -RRB- impairs cell invasion and epithelial-mesenchymal transition -LRB- EMT -RRB- - associated phenotype .
23108049	0	DUSP6	0,5	p53	43,46	DUSP6	p53	1848	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins .
23276385	0	DUSP9	32,37	Dual_specificity_phosphatase_9	0,30	DUSP9	Dual specificity phosphatase 9	1852	1852	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dual_specificity_phosphatase_9 -LRB- DUSP9 -RRB- expression is down-regulated in the severe pre-eclamptic placenta .
27084448	0	DVC1	63,67	PCNA	27,31	DVC1	PCNA	83932	5111	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human PCNA in complex with the PIP box of DVC1 .
19815336	0	DVL3	146,150	Wnt3	117,121	DVL3	Wnt3	1857	7473	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
26808213	0	DWARF1	33,39	BRI1	75,79	DWARF1	BRI1	821519(Tax:3702)	830095(Tax:3702)	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	Immunophilin-like FKBP42/TWISTED DWARF1 Interacts with the Receptor Kinase BRI1 to Regulate Brassinosteroid Signaling in Arabidopsis .
26233893	0	DWF4	105,109	DWF4	15,19	DWF4	DWF4	824229(Tax:3702)	824229(Tax:3702)	Gene	Gene	Region|nmod|START_ENTITY Expression|nmod|Region Expression|compound|END_ENTITY	TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis_thaliana .
26233893	0	DWF4	15,19	DWF4	105,109	DWF4	DWF4	824229(Tax:3702)	824229(Tax:3702)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Region Region|nmod|END_ENTITY	TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis_thaliana .
21822059	0	DWF4	44,48	TCP1	0,4	DWF4	TCP1	824229(Tax:3702)	821544(Tax:3702)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TCP1 positively regulates the expression of DWF4 in Arabidopsis_thaliana .
26233893	0	DWF4	105,109	TCP1	0,4	DWF4	TCP1	824229(Tax:3702)	821544(Tax:3702)	Gene	Gene	Region|nmod|START_ENTITY Expression|nmod|Region Expression|compound|END_ENTITY	TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis_thaliana .
26233893	0	DWF4	15,19	TCP1	0,4	DWF4	TCP1	824229(Tax:3702)	821544(Tax:3702)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis_thaliana .
20404857	0	DXR	67,70	1-deoxy-D-xylulose-5-phosphate_reductoisomerase	18,65	DXR	1-deoxy-D-xylulose-5-phosphate reductoisomerase	836400(Tax:3702)	836400(Tax:3702)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Disruption of the 1-deoxy-D-xylulose-5-phosphate_reductoisomerase -LRB- DXR -RRB- gene results in albino , dwarf and defects in trichome initiation and stomata closure in Arabidopsis .
3610256	0	DX_alpha	46,54	HLA-DQ_alpha	28,40	DX alpha	HLA-DQ alpha	3118	3117	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Structure and expression of HLA-DQ_alpha and - DX_alpha genes : interallelic alternate splicing of the HLA-DQ_alpha gene and functional splicing of the HLA-DQ_alpha gene using a retroviral vector .
19816122	0	DYNAMIN-RELATED_PROTEIN3A	68,93	DRP3A	95,100	DYNAMIN-RELATED PROTEIN3A	DRP3A	829506(Tax:3702)	829506(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Arabidopsis peroxisome division mutant pdd2 is defective in the DYNAMIN-RELATED_PROTEIN3A -LRB- DRP3A -RRB- gene .
21971545	0	DYNLL1	24,30	LC8	0,3	DYNLL1	LC8	8655	8655	Gene	Gene	chain|appos|START_ENTITY chain|compound|END_ENTITY	LC8 dynein light chain -LRB- DYNLL1 -RRB- binds to the C-terminal domain of ATM-interacting_protein -LRB- ATMIN/ASCIZ -RRB- and regulates its subcellular localization .
25944661	0	DYNLT1	93,99	CT850	49,54	DYNLT1	CT850	6993	884650(Tax:272561)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Chlamydia_trachomatis inclusion membrane protein CT850 interacts with the dynein light chain DYNLT1 -LRB- Tctex1 -RRB- .
21700358	0	DYNLT1	20,26	Tctex-1	11,18	DYNLT1	Tctex-1	6993	6993	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for Tctex-1 -LRB- DYNLT1 -RRB- in controlling primary cilium length .
9918863	0	DYRK	62,66	DYRK1B	32,38	DYRK	DYRK1B	1859	9149	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Cloning and characterization of DYRK1B , a novel member of the DYRK family of protein kinases .
11311121	0	DYRK	11,15	eIF2Bepsilon	67,79	DYRK	eIF2Bepsilon	1859	8893	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated_protein_tau at Thr212 : potential role for DYRK as a glycogen synthase kinase 3-priming kinase .
11311121	0	DYRK	163,167	microtubule-associated_protein_tau	98,132	DYRK	microtubule-associated protein tau	1859	4137	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated_protein_tau at Thr212 : potential role for DYRK as a glycogen synthase kinase 3-priming kinase .
11311120	0	DYRK1A	11,17	FKHR	58,62	DYRK1A	FKHR	1859	2308	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro , a novel in vivo phosphorylation site .
24806449	0	DYRK1A	41,47	Kip1	67,71	DYRK1A	Kip1	13548(Tax:10090)	12576(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The Down syndrome-related protein kinase DYRK1A phosphorylates p27 -LRB- Kip1 -RRB- and Cyclin_D1 and induces cell cycle exit and neuronal differentiation .
21777625	0	DYRK1A	0,6	WDR68	64,69	DYRK1A	WDR68	1859	10238	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation .
19016842	0	DYRK1A	0,6	caspase_9	22,31	DYRK1A	caspase 9	1859	842	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	DYRK1A phosphorylates caspase_9 at an inhibitory site and is potently inhibited in human cells by harmine .
21637297	0	DYRK1A	43,49	p53	0,3	DYRK1A	p53	1859	7157	Gene	Gene	syndrome-associated|dobj|START_ENTITY syndrome-associated|nsubj|downregulates downregulates|compound|END_ENTITY	p53 downregulates Down syndrome-associated DYRK1A through miR-1246 .
9918863	0	DYRK1B	32,38	DYRK	62,66	DYRK1B	DYRK	9149	1859	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Cloning and characterization of DYRK1B , a novel member of the DYRK family of protein kinases .
26346493	0	DYRK1B	97,103	ERK1/2	43,49	DYRK1B	ERK1/2	9149	5595;5594	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic_syndrome .
26346493	0	DYRK1B	97,103	ERK1/2	43,49	DYRK1B	ERK1/2	9149	5595;5594	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic_syndrome .
24134204	0	DYRK1B	49,55	GSK3b	78,83	DYRK1B	GSK3b	9149	2932	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3b to phosphorylate cyclin_D1 at Thr -LRB- 286 -RRB- , not Thr -LRB- 288 -RRB- .
26784250	0	DYRK1B	0,6	Smoothened	73,83	DYRK1B	Smoothened	9149	6608	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance .
23791882	0	DYRK2	0,5	Snail	83,88	DYRK2	Snail	8445	6615	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	DYRK2 controls the epithelial-mesenchymal transition in breast_cancer by degrading Snail .
22307329	0	DYRK2	0,5	c-Jun	33,38	DYRK2	c-Jun	8445	3725	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells .
17349958	0	DYRK2	0,5	p53	46,49	DYRK2	p53	8445	7157	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage .
26134855	0	DYSFUNCTIONAL_TAPETUM_1	47,70	DYT1	72,76	DYSFUNCTIONAL TAPETUM 1	DYT1	827883(Tax:3702)	827883(Tax:3702)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	One novel cis-element is essential for correct DYSFUNCTIONAL_TAPETUM_1 -LRB- DYT1 -RRB- expression in Arabidopsis_thaliana .
26134855	0	DYT1	72,76	DYSFUNCTIONAL_TAPETUM_1	47,70	DYT1	DYSFUNCTIONAL TAPETUM 1	827883(Tax:3702)	827883(Tax:3702)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	One novel cis-element is essential for correct DYSFUNCTIONAL_TAPETUM_1 -LRB- DYT1 -RRB- expression in Arabidopsis_thaliana .
25284309	0	DYT1	0,4	TDF1	42,46	DYT1	TDF1	827883(Tax:3702)	822477(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	DYT1 directly regulates the expression of TDF1 for tapetum development and pollen wall formation in Arabidopsis .
25337725	0	DYT1	31,35	TOR1-A	23,29	DYT1	TOR1-A	1861	1861	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Genetic evaluation for TOR1-A -LRB- DYT1 -RRB- in Brazilian patients with dystonia .
11523564	0	DYT1	29,33	TOR1A	22,27	DYT1	TOR1A	1861	1861	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel mutation in the TOR1A -LRB- DYT1 -RRB- gene in atypical early onset dystonia and polymorphisms_in_dystonia and early onset parkinsonism .
15930383	0	DYT1	60,64	torsinA	43,50	DYT1	torsinA	30931(Tax:10090)	30931(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY expressing|nmod|mutation expressing|dobj|END_ENTITY	Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation .
26687111	0	DYT27	94,99	COL6A3	76,82	DYT27	COL6A3	1293	1293	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	The clinical phenotype of early-onset isolated_dystonia caused by recessive COL6A3 mutations -LRB- DYT27 -RRB- .
20211909	0	DYT6	17,21	THAP1	0,5	DYT6	THAP1	55145	55145	Gene	Gene	mutations|appos|START_ENTITY mutations|nummod|END_ENTITY	THAP1 mutations -LRB- DYT6 -RRB- are an additional cause of early-onset dystonia .
7418270	0	D_beta_H	33,41	dopamine_beta-hydroxylase	6,31	D beta H	dopamine beta-hydroxylase	1621	1621	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum dopamine_beta-hydroxylase -LRB- D_beta_H -RRB- levels during tilting in patients with spinal_cord_injuries .
20223827	0	Daam1	96,101	Flightless-I	0,12	Daam1	Flightless-I	23002	2314	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Flightless-I -LRB- Fli-I -RRB- regulates the actin assembly activity of diaphanous-related formins -LRB- DRFs -RRB- Daam1 and mDia1 in cooperation with active Rho GTPase .
17974915	0	Dab1	19,23	Cullin_5	0,8	Dab1	Cullin 5	1600	8065	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Cullin_5 regulates Dab1 protein levels and neuron positioning during cortical development .
19931637	0	Dab1	91,95	Disabled-1	79,89	Dab1	Disabled-1	692351(Tax:7955)	692351(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterisation and differential expression during development of a duplicate Disabled-1 -LRB- Dab1 -RRB- gene from zebrafish .
20568118	0	Dab1	0,4	Fe65	14,18	Dab1	Fe65	1600	322	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing .
18374587	0	Dab1	55,59	PrP	24,27	Dab1	PrP	13131(Tax:10090)	19131(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Fibrillar prion peptide PrP -LRB- 106-126 -RRB- treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons .
12882964	0	Dab1	65,69	Reelin	85,91	Dab1	Reelin	1600	5649	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Phosphatidylinositol_3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination .
15249135	0	Dab1	25,29	Reelin	33,39	Dab1	Reelin	1600	5649	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper_layer_cortical_plate_neurons .
18514414	0	Dab1	102,106	Reln	83,87	Dab1	Reln	13131(Tax:10090)	19699(Tax:10090)	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1 ; Reln and Pafah1b1 ; Dab1 mutant mice .
25253241	0	Dab2	13,17	Akt	0,3	Dab2	Akt	1601	207	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Akt recruits Dab2 to albumin endocytosis in the proximal tubule .
14596919	0	Dab2	0,4	CIN85	11,16	Dab2	CIN85	1601	30011	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Dab2 links CIN85 with clathrin-mediated receptor internalization .
19767570	0	Dab2	14,18	FOXP3	24,29	Dab2	FOXP3	13132(Tax:10090)	20371(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Cutting edge : Dab2 is a FOXP3 target gene required for regulatory T cell function .
24638085	0	Dab2	8,12	TGF-b	80,85	Dab2	TGF-b	1601	7040	Gene	Gene	expression|amod|START_ENTITY Loss|nmod|expression impairs|nsubj|Loss impairs|dobj|ability ability|acl|deplete deplete|dobj|END_ENTITY	Loss of Dab2 expression in breast_cancer cells impairs their ability to deplete TGF-b and induce Tregs development via TGF-b .
24648493	0	Dab2	0,4	TGF-b	61,66	Dab2	TGF-b	1601	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-b .
10769163	0	Dab2	26,30	gp600/megalin	80,93	Dab2	gp600/megalin	1601	4036	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin .
11025208	0	Dacapo	52,58	cyclin_E	75,83	Dacapo	cyclin E	36001(Tax:7227)	34924(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin_E .
23552694	0	Dacapo	77,83	dSkp2	29,34	Dacapo	dSkp2	36001(Tax:7227)	40548(Tax:7227)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation .
22308399	0	Dachshund	23,32	Pax6	57,61	Dachshund	Pax6	34982(Tax:7227)	43833(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression .
18809931	0	Dachsous	14,22	Cadherin	23,31	Dachsous	Cadherin	33245(Tax:7227)	37386(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation .
20727855	0	Dad1	4,8	Dam1	42,46	Dad1	Dam1	851579(Tax:4932)	853010(Tax:4932)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|complex complex|compound|END_ENTITY	The Dad1 subunit of the yeast kinetochore Dam1 complex is an intrinsically disordered protein .
10421372	0	Dally	0,5	Drosophila_Frizzled_2	22,43	Dally	Drosophila Frizzled 2	39013(Tax:7227)	40090(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Dally cooperates with Drosophila_Frizzled_2 to transduce Wingless signalling .
14602684	0	Dally-like	13,23	Hedgehog	40,48	Dally-like	Hedgehog	39596(Tax:7227)	42737(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The glypican Dally-like is required for Hedgehog signalling in the embryonic_epidermis of Drosophila .
20727855	0	Dam1	42,46	Dad1	4,8	Dam1	Dad1	853010(Tax:4932)	851579(Tax:4932)	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex subunit|amod|END_ENTITY	The Dad1 subunit of the yeast kinetochore Dam1 complex is an intrinsically disordered protein .
12417666	0	Damage-induced_neuronal_endopeptidase	0,37	leukemia_inhibitory_factor	77,103	Damage-induced neuronal endopeptidase	leukemia inhibitory factor	60417(Tax:10116)	60584(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Damage-induced_neuronal_endopeptidase -LRB- DINE/ECEL -RRB- expression is regulated by leukemia_inhibitory_factor and deprivation of nerve_growth_factor in rat sensory ganglia after nerve_injury .
20395298	0	Damaged_DNA-binding_protein_1	0,29	Cdh1	52,56	Damaged DNA-binding protein 1	Cdh1	1642	999	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Damaged_DNA-binding_protein_1 -LRB- DDB1 -RRB- interacts with Cdh1 and modulates the function of APC/CCdh1 .
11520677	0	Dan	29,32	Dan	8,11	Dan	Dan	373697(Tax:8355)	373697(Tax:8355)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Xenopus Dan , a member of the Dan gene family of BMP antagonists , is expressed in derivatives of the cranial_and_trunk_neural_crest .
11520677	0	Dan	8,11	Dan	29,32	Dan	Dan	373697(Tax:8355)	373697(Tax:8355)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Xenopus Dan , a member of the Dan gene family of BMP antagonists , is expressed in derivatives of the cranial_and_trunk_neural_crest .
24879894	0	Dapper-1	0,8	Wnt5a	26,31	Dapper-1	Wnt5a	51339	7474	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway .
12554773	0	Dax-1	0,5	wnt4	146,150	Dax-1	wnt4	11614(Tax:10090)	22417(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Dax-1 -LRB- dosage-sensitive_sex_reversal-adrenal_hypoplasia_congenita critical region on the X chromosome , gene 1 -RRB- gene transcription is regulated by wnt4 in the female developing gonad .
20937355	0	Dax1	25,29	LRH-1	0,5	Dax1	LRH-1	11614(Tax:10090)	26424(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells .
19528230	0	Dax1	0,4	Oct3/4	14,20	Dax1	Oct3/4	190	5460	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells .
20943815	0	Dax1	0,4	Oct4	18,22	Dax1	Oct4	11614(Tax:10090)	18999(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA .
9743501	0	Daxx	81,85	ASK1	52,56	Daxx	ASK1	1616	4217	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by the adapter protein Daxx .
16311507	0	Daxx	40,44	CD40	80,84	Daxx	CD40	1616	958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The PML-nuclear body associated protein Daxx regulates the cellular response to CD40 .
21573799	0	Daxx	14,18	FTH1	0,4	Daxx	FTH1	1616	2495	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis .
11112409	0	Daxx	15,19	Fas_binding_protein	23,42	Daxx	Fas binding protein	1616	1616	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of Daxx , a Fas_binding_protein , with sentrin and Ubc9 .
15364927	0	Daxx	40,44	MDM2	68,72	Daxx	MDM2	1616	4193	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of p53 functions by Daxx and the involvement of MDM2 .
16845383	0	Daxx	18,22	Mdm2	37,41	Daxx	Mdm2	13163(Tax:10090)	17246(Tax:10090)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Critical role for Daxx in regulating Mdm2 .
20153724	0	Daxx	0,4	Mdm2	34,38	Daxx	Mdm2	1616	4193	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Daxx is reciprocally regulated by Mdm2 and Hausp .
23536002	0	Daxx	46,50	Pdcd4	25,30	Daxx	Pdcd4	1616	27250	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tumor_suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46 .
9743501	0	Daxx	81,85	apoptosis_signal-regulating_kinase_1	14,50	Daxx	apoptosis signal-regulating kinase 1	1616	4217	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by the adapter protein Daxx .
15364927	0	Daxx	40,44	p53	23,26	Daxx	p53	1616	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|functions functions|compound|END_ENTITY	Negative regulation of p53 functions by Daxx and the involvement of MDM2 .
11112409	0	Daxx	15,19	sentrin	49,56	Daxx	sentrin	1616	7341	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Daxx , a Fas_binding_protein , with sentrin and Ubc9 .
17933869	0	Daxx-like_protein	0,17	Dmp53	47,52	Daxx-like protein	Dmp53	33906(Tax:7227)	2768677(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Daxx-like_protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level .
17157269	0	DbetaH	32,38	Dopamine_beta-hydroxylase	0,25	DbetaH	Dopamine beta-hydroxylase	1621	1621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dopamine_beta-hydroxylase gene -LRB- DbetaH -RRB- -1021 C -- > T influences self-reported paranoia during cocaine self-administration .
22573892	0	Dbf2	20,24	Chs2	65,69	Dbf2	Chs2	852984(Tax:4932)	852326(Tax:4932)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast .
25353004	0	Dbh	16,19	Foxo1	0,5	Dbh	Foxo1	13166(Tax:10090)	56458(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Foxo1 regulates Dbh expression and the activity of the sympathetic nervous system in vivo .
11502748	0	Dbl	4,7	BCR	27,30	Dbl	BCR	109904(Tax:10090)	110279(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome .
11373293	0	Dbl	62,65	Leukemia-associated_Rho_guanine_nucleotide_exchange_factor	0,58	Dbl	Leukemia-associated Rho guanine nucleotide exchange factor	4168	23365	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Leukemia-associated_Rho_guanine_nucleotide_exchange_factor , a Dbl family protein found mutated in leukemia , causes transformation by activation of RhoA .
2265564	0	Dbl	33,36	Mcf-2	26,31	Dbl	Mcf-2	109904(Tax:10090)	109904(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the mouse Mcf-2 -LRB- Dbl -RRB- protooncogene within a conserved linkage group on the mouse X chromosome .
11337492	0	Dbl	0,3	NF_kappa_B	33,43	Dbl	NF kappa B	4168	4790	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Dbl and the Rho GTPases activate NF_kappa_B by I kappa B kinase -LRB- IKK -RRB- - dependent and IKK-independent pathways .
10777665	0	Dbl	48,51	Ngef	20,24	Dbl	Ngef	4168	25791	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Characterization of Ngef , a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus .
11062019	0	Dbl	53,56	RhoA	14,18	Dbl	RhoA	109904(Tax:10090)	11848(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of RhoA by association of Galpha -LRB- 13 -RRB- with Dbl .
10748082	0	Dbl	75,78	Vav	99,102	Dbl	Vav	4168	7409	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding .
11007481	0	Dbl	53,56	Vav	91,94	Dbl	Vav	4168	7409	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation .
15064738	0	Dbl	88,91	ezrin	55,60	Dbl	ezrin	4168	7430	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo .
11565753	0	Dbp6p	119,124	Dbp9p	0,5	Dbp6p	Dbp9p	855774(Tax:4932)	850982(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dbp9p , a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis , functionally interacts with Dbp6p .
15126390	0	Dbp6p	26,31	Rpl3p	60,65	Dbp6p	Rpl3p	855774(Tax:4932)	854229(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The putative RNA helicase Dbp6p functionally interacts with Rpl3p , Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces_cerevisiae .
11565753	0	Dbp9p	0,5	Dbp6p	119,124	Dbp9p	Dbp6p	850982(Tax:4932)	855774(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dbp9p , a putative ATP-dependent RNA helicase involved in 60S-ribosomal-subunit biogenesis , functionally interacts with Dbp6p .
24751947	0	Dbx1	0,4	SOX3	27,31	Dbx1	SOX3	120237	6658	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Dbx1 is a direct target of SOX3 in the spinal cord .
21699018	0	DcR3	38,42	decoy_receptor-3	20,36	DcR3	decoy receptor-3	8771	8771	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of death decoy_receptor-3 -LRB- DcR3 -RRB- in human breast_cancer and its functional effects on breast_cancer cells in vitro .
10632670	0	DcR3	41,45	decoy_receptor_3	23,39	DcR3	decoy receptor 3	8771	8771	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Over-expression of the decoy_receptor_3 -LRB- DcR3 -RRB- gene in peripheral blood mononuclear cells -LRB- PBMC -RRB- derived from silicosis patients .
23846297	0	DcR3	31,35	decoy_receptor_3	13,29	DcR3	decoy receptor 3	8771	8771	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Silencing of decoy_receptor_3 -LRB- DcR3 -RRB- expression by siRNA in pancreatic_carcinoma cells induces Fas_ligand-mediated apoptosis in vitro and in vivo .
26062966	0	DcR3	32,36	decoy_receptor_3	14,30	DcR3	decoy receptor 3	8771	8771	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	The serologic decoy_receptor_3 -LRB- DcR3 -RRB- levels are associated with slower disease progression in HIV-1 / AIDS patients .
19748482	0	DcR3	0,4	integrin_alpha4	61,76	DcR3	integrin alpha4	8771	3676	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|nmod|END_ENTITY	DcR3 protects THP-1 macrophages from apoptosis by increasing integrin_alpha4 .
10085257	0	Dcdc42	0,6	TGF-beta	15,23	Dcdc42	TGF-beta	32981(Tax:7227)	43804(Tax:7227)	Gene	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis : distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation .
15988528	0	Dcn1p	28,33	DCN-1	22,27	Dcn1p	DCN-1	175556(Tax:6239)	175556(Tax:6239)	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	The conserved protein DCN-1 / Dcn1p is required for cullin neddylation in C. _ elegans and S. _ cerevisiae .
12032091	0	Dcp1	58,62	Dhh1	21,25	Dcp1	Dhh1	854016(Tax:4932)	851394(Tax:4932)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1 .
16954406	0	Dcpp	102,106	CSP-1	96,101	Dcpp	CSP-1	13184(Tax:10090)	1827	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Identification of a human ortholog of the mouse Dcpp gene locus , encoding a novel member of the CSP-1 / Dcpp salivary protein family .
18637555	0	Dcx	38,41	Doublecortin	24,36	Dcx	Doublecortin	13193(Tax:10090)	13193(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Postnatal expression of Doublecortin -LRB- Dcx -RRB- in the developing cerebellar cortex of mouse .
17968140	0	Ddc	48,51	dopa_decarboxylase	28,46	Ddc	dopa decarboxylase	35190(Tax:7227)	35190(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Nucleotide variation at the dopa_decarboxylase -LRB- Ddc -RRB- gene in natural populations of Drosophila_melanogaster .
24586187	0	Ddc2	0,4	Mec1	14,18	Ddc2	Mec1	852110(Tax:4932)	852433(Tax:4932)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Ddc2 mediates Mec1 activation through a Ddc1 - or Dpb11-independent mechanism .
18483174	0	Ddr2	104,108	collagen_receptor	80,97	Ddr2	collagen receptor	18214(Tax:10090)	16398(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel dwarfism with gonadal_dysfunction due to loss-of-function allele of the collagen_receptor gene , Ddr2 , in the mouse .
20225156	0	Ddx5	34,38	p68	29,32	Ddx5	p68	1655	1655	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of the RNA helicase p68 -LRB- Ddx5 -RRB- as a transcriptional regulator .
14739464	0	De-etiolated-1	6,20	c-Jun	31,36	De-etiolated-1	c-Jun	55070	3725	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase .
16342413	0	Deadpan	30,37	CK2	11,14	Deadpan	CK2	35800(Tax:7227)	48448(Tax:7227)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Drosophila CK2 phosphorylates Deadpan , a member of the HES family of basic-helix-loop-helix -LRB- bHLH -RRB- repressors .
25135476	0	Death-Associated_Protein_Kinase_1	18,51	Apoptosis_Signal-Regulating_Kinase_1	95,131	Death-Associated Protein Kinase 1	Apoptosis Signal-Regulating Kinase 1	69635(Tax:10090)	26408(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Regulation|nmod|Expression Regulation|nmod|END_ENTITY	Regulation of the Death-Associated_Protein_Kinase_1 Expression and Autophagy via ATF6 Requires Apoptosis_Signal-Regulating_Kinase_1 .
12384512	0	Death-associated_protein_4	0,26	MST1	33,37	Death-associated protein 4	MST1	5612	4485	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Death-associated_protein_4 binds MST1 and augments MST1-induced apoptosis .
22490852	0	Death-associated_protein_kinase	1,32	DAPK	43,47	Death-associated protein kinase	DAPK	1612	1612	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	-LSB- Death-associated_protein_kinase promoter -LRB- DAPK -RRB- hypermethylation in uterine cervical_cancer and intraepithelial_neoplasia in Uyghur nationality women -RSB- .
17087515	0	Death-associated_protein_kinase	0,31	ribosomal_protein_S6	57,77	Death-associated protein kinase	ribosomal protein S6	1612	6194	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Death-associated_protein_kinase phosphorylates mammalian ribosomal_protein_S6 and reduces protein synthesis .
21497122	0	Death-associated_protein_kinase_1	0,33	Pin1	49,53	Death-associated protein kinase 1	Pin1	1612	5300	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Death-associated_protein_kinase_1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function .
26718429	0	Death_Receptor	110,124	DR4	126,129	Death Receptor	DR4	8797	8797	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Genetic variants in the tumor_Necrosis_Factor-Related_Apoptosis-Inducing_Ligand -LRB- TRAIL -RRB- do not contribute but Death_Receptor -LRB- DR4 -RRB- genes may contribute to susceptibility to head_and_neck_cancer in Pakistani population .
25207117	0	Death_Receptor_4	25,41	DR4	43,46	Death Receptor 4	DR4	8797	8797	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	A Study of the Impact of Death_Receptor_4 -LRB- DR4 -RRB- Gene Polymorphisms in Alzheimer 's _ Disease .
27053682	0	Death_Receptor_4	51,67	TRAIL	19,24	Death Receptor 4	TRAIL	8797	8743	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	HuR Contributes to TRAIL Resistance by Restricting Death_Receptor_4 Expression in Pancreatic_Cancer Cells .
22469980	0	Death_inducer-obliterator_1	0,27	BMP	41,44	Death inducer-obliterator 1	BMP	11083	649	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Death_inducer-obliterator_1 -LRB- Dido1 -RRB- is a BMP target gene and promotes BMP-induced melanoma progression .
18421578	0	Death_receptor-4	0,16	DR4	18,21	Death receptor-4	DR4	8797	8797	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Death_receptor-4 -LRB- DR4 -RRB- expression is regulated by transcription factor NF-kappaB in response to etoposide treatment .
18421578	0	Death_receptor-4	0,16	NF-kappaB	71,80	Death receptor-4	NF-kappaB	8797	4790	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Death_receptor-4 -LRB- DR4 -RRB- expression is regulated by transcription factor NF-kappaB in response to etoposide treatment .
15241467	0	Death_receptor_3	0,16	DR3	18,21	Death receptor 3	DR3	8718	8718	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Death_receptor_3 -LRB- DR3 -RRB- gene duplication in a chromosome region 1p36 .3 : gene duplication is more prevalent in rheumatoid_arthritis .
10684252	0	Debcl	0,5	Bcl-2	22,27	Debcl	Bcl-2	53585(Tax:7227)	53585(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|amod|END_ENTITY	Debcl , a proapoptotic Bcl-2 homologue , is a component of the Drosophila_melanogaster cell death machinery .
25208640	0	Debcl	36,41	slimb	96,101	Debcl	slimb	53585(Tax:7227)	42504(Tax:7227)	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the b-TrCP homologue slimb .
25903025	0	Decorin	27,34	TGF-b1	44,50	Decorin	TGF-b1	1634	7040	Gene	Gene	Inhibits|compound|START_ENTITY END_ENTITY|nsubj|Inhibits	Recombinant Human Decorin Inhibits TGF-b1 Induced Contraction of Collagen Lattice by Keloid Fibroblasts .
12707320	0	Decorin	0,7	TGF-beta	61,69	Decorin	TGF-beta	13179(Tax:10090)	21803(Tax:10090)	Gene	Gene	reverses|nsubj|START_ENTITY reverses|dobj|effect effect|nmod|END_ENTITY	Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation .
21454550	0	Decorin	0,7	connective_tissue_growth_factor	23,54	Decorin	connective tissue growth factor	1634	1490	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Decorin interacts with connective_tissue_growth_factor -LRB- CTGF -RRB- / CCN2 by LRR12 inhibiting its biological activity .
15994311	0	Decorin	0,7	epidermal_growth_factor_receptor	65,97	Decorin	epidermal growth factor receptor	1634	1956	Gene	Gene	evokes|nsubj|START_ENTITY evokes|dobj|internalization internalization|nmod|END_ENTITY	Decorin evokes protracted internalization and degradation of the epidermal_growth_factor_receptor via caveolar endocytosis .
16835231	0	Decorin	0,7	epidermal_growth_factor_receptor	80,112	Decorin	epidermal growth factor receptor	1634	1956	Gene	Gene	core|compound|START_ENTITY inhibits|nsubj|core inhibits|advcl|hindering hindering|dobj|function function|compound|END_ENTITY	Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal_growth_factor_receptor function and triggering apoptosis via caspase-3 activation .
9435313	0	Decorin	0,7	epidermal_growth_factor_receptor	55,87	Decorin	epidermal growth factor receptor	1634	1956	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|activating activating|dobj|END_ENTITY	Decorin suppresses tumor cell growth by activating the epidermal_growth_factor_receptor .
9452417	0	Decorin	0,7	epidermal_growth_factor_receptor	22,54	Decorin	epidermal growth factor receptor	1634	1956	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Decorin activates the epidermal_growth_factor_receptor and elevates cytosolic Ca2 + in A431 carcinoma cells .
9988678	0	Decorin	0,7	epidermal_growth_factor_receptor	39,71	Decorin	epidermal growth factor receptor	1634	1956	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Decorin is a biological ligand for the epidermal_growth_factor_receptor .
11567999	0	Decorin	0,7	macrophage_colony-stimulating_factor	17,53	Decorin	macrophage colony-stimulating factor	1634	1435	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|amod|END_ENTITY	Decorin inhibits macrophage_colony-stimulating_factor proliferation of macrophages and enhances cell survival through induction of p27 -LRB- Kip1 -RRB- and p21 -LRB- Waf1 -RRB- .
16380093	0	Decorin	0,7	myostatin	14,23	Decorin	myostatin	1634	2660	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Decorin binds myostatin and modulates its activity to muscle cells .
16230375	0	Decoy_receptor_2	0,16	p53	29,32	Decoy receptor 2	p53	8793	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Decoy_receptor_2 -LRB- DcR2 -RRB- is a p53 target gene and regulates chemosensitivity .
23533666	0	Dectin-1	0,8	IL-10	19,24	Dectin-1	IL-10	56644(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers .
18200499	0	Dectin-1	77,85	Syk	0,3	Dectin-1	Syk	64581	6850	Gene	Gene	receptors|amod|START_ENTITY induced|nmod|receptors production|acl|induced required|nmod|production required|nsubjpass|kinase kinase|compound|END_ENTITY	Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors .
22633994	0	Dectin-1	0,8	Syk	9,12	Dectin-1	Syk	56644(Tax:10090)	20963(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|signaling signaling|compound|END_ENTITY	Dectin-1 / Syk signaling is involved in Lactobacillus casei cell wall extract-induced mouse model of Kawasaki_disease .
18549457	0	Dectin-1	0,8	TLR2	25,29	Dectin-1	TLR2	64581	7097	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages .
23787127	0	Dectin-1	95,103	TLR2	37,41	Dectin-1	TLR2	64581	7097	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1 .
23844079	0	Dectin-1	0,8	TLR2	9,13	Dectin-1	TLR2	64581	7097	Gene	Gene	START_ENTITY|parataxis|render render|nsubj|agonists agonists|compound|END_ENTITY	Dectin-1 / TLR2 and NOD2 agonists render dendritic cells susceptible to infection by X4-using HIV-1 and promote cis-infection of CD4 -LRB- + -RRB- T cells .
12606478	0	Decysin	0,7	prolactin	71,80	Decysin	prolactin	58860(Tax:10090)	19109(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Decysin , a new member of the metalloproteinase family , is regulated by prolactin and steroids during mouse pregnancy .
17403664	0	Def-6	0,5	Rac1	48,52	Def-6	Rac1	50619	5879	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Def-6 , a guanine_nucleotide exchange factor for Rac1 , interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation .
24465179	0	Def1	0,4	Pol3	33,37	Def1	Pol3	853811(Tax:4932)	851456(Tax:4932)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage -- induced mutagenesis in Saccharomyces_cerevisiae .
26374165	0	Del-1	61,66	IL-17	24,29	Del-1	IL-17	10085	3605	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3b-C / EBPb pathway .
18322824	0	Del1	42,46	epidermal_growth_factor-like_repeat	3,38	Del1	epidermal growth factor-like repeat	10085	1738	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	An epidermal_growth_factor-like_repeat of Del1 protein increases the efficiency of gene transfer in vitro .
12459492	0	DelGEF	0,6	Sec5	105,109	DelGEF	Sec5	26297	55770	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	DelGEF , a homologue of the Ran guanine_nucleotide exchange factor RanGEF , binds to the exocyst component Sec5 and modulates secretion .
16884537	0	Deleted-in-AZoospermia-Like	32,59	DAZL	61,65	Deleted-in-AZoospermia-Like	DAZL	1618	1618	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel missense mutations of the Deleted-in-AZoospermia-Like -LRB- DAZL -RRB- gene in infertile women and men .
10484770	0	Deleted_in_AZoospermia	26,48	DAZ	21,24	Deleted in AZoospermia	DAZ	1617	1617	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Old World monkey DAZ -LRB- Deleted_in_AZoospermia -RRB- gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome .
23055411	0	Deleted_in_AZoospermia	86,108	DAZ	81,84	Deleted in AZoospermia	DAZ	100286803(Tax:9544)	100286803(Tax:9544)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Sequencing of rhesus_macaque Y chromosome clarifies origins and evolution of the DAZ -LRB- Deleted_in_AZoospermia -RRB- genes .
9091344	0	Deleted_in_AZoospermia	63,85	DAZ	58,61	Deleted in AZoospermia	DAZ	1617	1617	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Screening for deletions of the Y chromosome involving the DAZ -LRB- Deleted_in_AZoospermia -RRB- gene in azoospermia and severe oligozoospermia .
9557839	0	Deleted_in_AZoospermia	5,27	DAZ	0,3	Deleted in AZoospermia	DAZ	1617	1617	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	DAZ -LRB- Deleted_in_AZoospermia -RRB- genes encode proteins located in human late spermatids and in sperm tails .
19281782	0	Deleted_in_Azoospermia-Like	79,106	DAZL	108,112	Deleted in Azoospermia-Like	DAZL	1618	1618	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An epigenetic mechanism regulates germ cell-specific expression of the porcine Deleted_in_Azoospermia-Like -LRB- DAZL -RRB- gene .
26378077	0	Deleted_in_Breast_Cancer_1	0,26	RelB	64,68	Deleted in Breast Cancer 1	RelB	56710(Tax:10090)	19698(Tax:10090)	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|nmod|END_ENTITY	Deleted_in_Breast_Cancer_1 Suppresses B Cell Activation through RelB and Is Regulated by IKKa Phosphorylation .
25525271	0	Deleted_in_Liver_Cancer_1	74,99	Epidermal_Growth_Factor	0,23	Deleted in Liver Cancer 1	Epidermal Growth Factor	10395	1950	Gene	Gene	Activates|dobj|START_ENTITY Activates|nsubj|END_ENTITY	Epidermal_Growth_Factor Activates the Rho GTPase-activating Protein -LRB- GAP -RRB- Deleted_in_Liver_Cancer_1 via Focal Adhesion Kinase and Protein Phosphatase_2A .
20071779	0	Deleted_in_breast_cancer-1	0,26	SIRT1	37,42	Deleted in breast cancer-1	SIRT1	56710(Tax:10090)	93759(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Deleted_in_breast_cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver_steatosis in mice .
15728532	0	Deleted_in_polyposis_1-like_1	0,29	Dp1l1	36,41	Deleted in polyposis 1-like 1	Dp1l1	70335(Tax:10090)	70335(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deleted_in_polyposis_1-like_1 gene -LRB- Dp1l1 -RRB- : a novel gene richly expressed in retinal_ganglion cells .
17878313	0	Delta-like-1	21,33	Notch1	0,6	Delta-like-1	Notch1	28514	4851	Gene	Gene	engagement|nmod|START_ENTITY engagement|amod|END_ENTITY	Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells .
19724883	0	Delta-like-1	38,50	Notch1	0,6	Delta-like-1	Notch1	28514	4851	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line .
21517260	0	Delta-like_ligand_4	15,34	DLL4	36,40	Delta-like ligand 4	DLL4	54567	54567	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of Delta-like_ligand_4 -LRB- DLL4 -RRB- with VEGF and HIF-1a expression in human glioma .
17296940	0	Delta-like_ligand_4	0,19	VEGF	41,45	Delta-like ligand 4	VEGF	54567	7422	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Delta-like_ligand_4 -LRB- Dll4 -RRB- is induced by VEGF as a negative regulator of angiogenic sprouting .
21517260	0	Delta-like_ligand_4	15,34	VEGF	47,51	Delta-like ligand 4	VEGF	54567	7422	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|expression expression|amod|END_ENTITY	Correlation of Delta-like_ligand_4 -LRB- DLL4 -RRB- with VEGF and HIF-1a expression in human glioma .
17485162	0	Delta-like_protein_1	43,63	growth_hormone	14,28	Delta-like protein 1	growth hormone	114587(Tax:10116)	81668(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of growth_hormone expression by Delta-like_protein_1 -LRB- Dlk1 -RRB- .
14529612	0	Delta1	95,101	Acvrinp1	39,47	Delta1	Acvrinp1	13388(Tax:10090)	50791(Tax:10090)	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of the MAGUK family member Acvrinp1 and the cytoplasmic domain of the Notch ligand Delta1 .
15485825	0	Delta1	17,23	Dlg1	33,37	Delta1	Dlg1	8788	1739	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration .
10473135	0	Delta1	14,20	Jagged1	35,42	Delta1	Jagged1	13388(Tax:10090)	16449(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Delta1 and Serrate1 -LRB- Jagged1 -RRB- in the mouse inner ear .
10958687	0	Delta1	11,17	Notch2	43,49	Delta1	Notch2	8788	4853	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Delta1 , Jagged1 , and Jagged2 to Notch2 rapidly induces cleavage , nuclear translocation , and hyperphosphorylation of Notch2 .
15674322	0	DeltaEF1	0,8	E-cadherin	43,53	DeltaEF1	E-cadherin	6935	999	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast_cancer cells .
11153911	0	Deltex	116,122	DTX1	124,128	Deltex	DTX1	1840	1840	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization , genomic characterization , and mapping to the Noonan_syndrome critical region of the human Deltex -LRB- DTX1 -RRB- gene .
11564735	0	Deltex-1	8,16	Notch	66,71	Deltex-1	Notch	1840	31293(Tax:7227)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|receptor receptor|compound|END_ENTITY	Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor .
15082708	0	Deltex1	24,31	Notch1	5,11	Deltex1	Notch1	1840	4851	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	NB-3 / Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes .
26218273	0	Demethylase	4,15	FTO	28,31	Demethylase	FTO	8932	79068	Gene	Gene	Activity|amod|START_ENTITY Activity|nmod|END_ENTITY	The Demethylase Activity of FTO -LRB- Fat_Mass_and_Obesity_Associated_Protein -RRB- Is Required for Preadipocyte Differentiation .
26218273	0	Demethylase	4,15	Fat_Mass_and_Obesity_Associated_Protein	33,72	Demethylase	Fat Mass and Obesity Associated Protein	8932	79068	Gene	Gene	Activity|amod|START_ENTITY Activity|appos|END_ENTITY	The Demethylase Activity of FTO -LRB- Fat_Mass_and_Obesity_Associated_Protein -RRB- Is Required for Preadipocyte Differentiation .
20693543	0	Dendritic_cell_nuclear_protein-1	0,32	corticotropin-releasing_hormone	82,113	Dendritic cell nuclear protein-1	corticotropin-releasing hormone	140947	1392	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Dendritic_cell_nuclear_protein-1 , a novel depression-related protein , upregulates corticotropin-releasing_hormone expression .
12390249	0	Densin-180	0,10	PSD-95	41,47	Densin-180	PSD-95	57554	1742	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	Densin-180 , a synaptic protein , links to PSD-95 through its direct interaction with MAGUIN-1 .
25940145	0	Dentin_Sialophosphoprotein	21,47	COUP-TFII	0,9	Dentin Sialophosphoprotein	COUP-TFII	25254(Tax:10116)	113984(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	COUP-TFII Stimulates Dentin_Sialophosphoprotein Expression and Mineralization in Odontoblasts .
25583546	0	Dentin_Sialophosphoprotein	16,42	Leptin	0,6	Dentin Sialophosphoprotein	Leptin	1834	3952	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Leptin Promotes Dentin_Sialophosphoprotein Expression in Human Dental Pulp .
25138274	0	Dentin_Sialophosphoprotein	36,62	Nuclear_Factor_I-C	0,18	Dentin Sialophosphoprotein	Nuclear Factor I-C	1834	4782	Gene	Gene	Regulates|xcomp|START_ENTITY Regulates|nsubj|END_ENTITY	Nuclear_Factor_I-C -LRB- NFIC -RRB- Regulates Dentin_Sialophosphoprotein -LRB- DSPP -RRB- and E-cadherin via Control of Kr ppel-like Factor 4 -LRB- KLF4 -RRB- During Dentinogenesis .
21190990	0	Dentin_matrix_protein_1	0,23	VE-cadherin	55,66	Dentin matrix protein 1	VE-cadherin	1758	1003	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Dentin_matrix_protein_1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation .
16679514	0	Dentin_matrix_protein_1	0,23	dentin_sialophosphoprotein	34,60	Dentin matrix protein 1	dentin sialophosphoprotein	1758	1834	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Dentin_matrix_protein_1 regulates dentin_sialophosphoprotein gene transcription during early odontoblast differentiation .
24089527	0	Derlin-1	26,34	Caveolin-1	0,10	Derlin-1	Caveolin-1	79139	857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex .
16954204	0	Derlin-1	0,8	cystic_fibrosis_transmembrane_conductance_regulator	51,102	Derlin-1	cystic fibrosis transmembrane conductance regulator	79139	1080	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Derlin-1 promotes the efficient degradation of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- and CFTR folding mutants .
9895299	0	Dermatopontin	0,13	transforming_growth_factor_beta	29,60	Dermatopontin	transforming growth factor beta	1805	7040	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dermatopontin interacts with transforming_growth_factor_beta and enhances its biological activity .
21397687	0	Dermcidin	18,27	Nck1	58,62	Dermcidin	Nck1	117159	4690	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration .
21151980	0	Desmoglein_3	0,12	E-cadherin	38,48	Desmoglein 3	E-cadherin	1830	999	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Desmoglein_3 , via an interaction with E-cadherin , is associated with activation of Src .
24504014	0	Developmental_endothelial_locus-1	0,33	MIF	43,46	Developmental endothelial locus-1	MIF	13612(Tax:10090)	17319(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Developmental_endothelial_locus-1 inhibits MIF production through suppression of NF-kB in macrophages .
18922798	0	Dexras1	0,7	FE65	23,27	Dexras1	FE65	51655	322	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription .
17083136	0	Dfm1	13,17	Cdc48	33,38	Dfm1	Cdc48	852020(Tax:4932)	851431(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis .
19836241	0	Dgt6	11,15	Ndc80	31,36	Dgt6	Ndc80	43441(Tax:7227)	32316(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Drosophila Dgt6 interacts with Ndc80 , Msps/XMAP215 , and gamma-tubulin to promote kinetochore-driven MT formation .
8689588	0	Dh	37,39	Dominant_hemimelia	41,59	Dh	Dominant hemimelia	109698(Tax:10090)	109698(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Skeletal_malformations caused by the Dh -LRB- Dominant_hemimelia -RRB- gene in mice .
12032091	0	Dhh1	21,25	Dcp1	58,62	Dhh1	Dcp1	851394(Tax:4932)	854016(Tax:4932)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1 .
21998293	0	Dhh1p	17,22	Rbp1p	39,44	Dhh1p	Rbp1p	851394(Tax:4932)	5947	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The RNA helicase Dhh1p cooperates with Rbp1p to promote porin mRNA decay via its non-conserved C-terminal domain .
1902572	0	Dhr6	0,4	RAD6	56,60	Dhr6	RAD6	40610(Tax:7227)	852822(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Dhr6 , a Drosophila homolog of the yeast DNA-repair gene RAD6 .
15821931	0	DiGeorge_critical_region_6	60,86	DGCR6	88,93	DiGeorge critical region 6	DGCR6	8214	8214	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Biochemical characterisation of the proteins encoded by the DiGeorge_critical_region_6 -LRB- DGCR6 -RRB- genes .
23157514	0	DiRas3	22,28	C-RAF	44,49	DiRas3	C-RAF	9077	5894	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The tumour suppressor DiRas3 interacts with C-RAF and downregulates MEK activity to restrict cell migration .
1823952	0	Dia	34,37	Diego_blood-group	47,64	Dia	Diego blood-group	1730	6521	Gene	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	-LSB- Studies of occurrence of antigen Dia from the Diego_blood-group system in the Polish population -RSB- .
17182868	0	Dia1	19,23	Mitf	0,4	Dia1	Mitf	1729	4286	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Mitf regulation of Dia1 controls melanoma proliferation and invasiveness .
18572016	0	Dia1	112,116	Neurochondrin	18,31	Dia1	Neurochondrin	1729	23154	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1 .
15200432	0	Diacylglycerol_acyltransferase-1	35,67	DGAT-1	69,75	Diacylglycerol acyltransferase-1	DGAT-1	84497(Tax:10116)	84497(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Up-regulation of hepatic Acyl_CoA : Diacylglycerol_acyltransferase-1 -LRB- DGAT-1 -RRB- expression in nephrotic_syndrome .
22918940	0	Diacylglycerol_kinase	0,21	RhoA	35,39	Diacylglycerol kinase	RhoA	1607	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Diacylglycerol_kinase regulates RhoA activation via a kinase-independent scaffolding mechanism .
23184957	0	Diacylglycerol_kinase	0,21	pleckstrin_homology_domain_leucine-rich_repeat_protein_phosphatase_2	63,131	Diacylglycerol kinase	pleckstrin homology domain leucine-rich repeat protein phosphatase 2	1607	23035	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Diacylglycerol_kinase modulates Akt phosphorylation through pleckstrin_homology_domain_leucine-rich_repeat_protein_phosphatase_2 -LRB- PHLPP2 -RRB- .
22895365	0	Diacylglycerol_kinase	0,21	tyrosinase	32,42	Diacylglycerol kinase	tyrosinase	1607	7299	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Diacylglycerol_kinase regulates tyrosinase expression and function in human melanocytes .
17700527	0	Diacylglycerol_kinase-alpha	0,27	Src	47,50	Diacylglycerol kinase-alpha	Src	1606	6714	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Diacylglycerol_kinase-alpha phosphorylation by Src on Y335 is required for activation , membrane recruitment and Hgf-induced cell motility .
22546945	0	Diacylglycerol_kinase_zeta	0,26	ICAM-1	93,99	Diacylglycerol kinase zeta	ICAM-1	8525	3383	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Diacylglycerol_kinase_zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow .
3111196	0	Diamine_oxidase	0,15	DAO	17,20	Diamine oxidase	DAO	26	26	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Diamine_oxidase -LRB- DAO -RRB- activity and intestinal mucosa integrity : influence of suture techniques .
16664015	0	Diaphorase	28,38	Ferredoxin-NADP_Reductase	66,91	Diaphorase	Ferredoxin-NADP Reductase	1738	2232	Gene	Gene	Activity|compound|START_ENTITY Effect|nmod|Activity Effect|nmod|END_ENTITY	Effect of Ferredoxin on the Diaphorase Activity of Cyanobacterial Ferredoxin-NADP_Reductase .
22922797	0	Dicer	44,49	ATR	19,22	Dicer	ATR	23405	545	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	miR-3928 activates ATR pathway by targeting Dicer .
23066106	0	Dicer	35,40	AUF1	20,24	Dicer	AUF1	23405	3184	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	RNA-binding_protein AUF1 represses Dicer expression .
23047949	0	Dicer	20,25	CLIMP-63	62,70	Dicer	CLIMP-63	23405	10970	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human Dicer by the resident ER membrane protein CLIMP-63 .
24287487	0	Dicer	23,28	Cyclin_D1	0,9	Dicer	Cyclin D1	23405	595	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cyclin_D1 induction of Dicer governs microRNA processing and expression in breast_cancer .
19155329	0	Dicer	50,55	FMRP	19,23	Dicer	FMRP	23405	2332	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of FMRP inhibits association with Dicer .
26943772	0	Dicer	0,5	HIF-2a	104,110	Dicer	HIF-2a	23405	2034	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Dicer suppresses the malignant phenotype in VHL-deficient_clear_cell_renal_cell_carcinoma by inhibiting HIF-2a .
24913918	0	Dicer	80,85	MicroRNA-581	0,12	Dicer	MicroRNA-581	23405	693166	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-581 promotes hepatitis_B virus surface antigen expression by targeting Dicer and EDEM1 .
17303335	0	Dicer	26,31	PHLDA2	16,22	Dicer	PHLDA2	23405	7262	Gene	Gene	cells|compound|START_ENTITY Upregulation|nmod|cells Upregulation|nmod|END_ENTITY	Upregulation of PHLDA2 in Dicer knockdown HEK293 cells .
26704979	0	Dicer	0,5	SIRT7	21,26	Dicer	SIRT7	23405	51547	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents .
15973356	0	Dicer	18,23	TRBP	0,4	Dicer	TRBP	23405	6896	Gene	Gene	complex|compound|START_ENTITY recruits|dobj|complex recruits|nsubj|END_ENTITY	TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing .
16142218	0	Dicer	77,82	TRBP	0,4	Dicer	TRBP	23405	6896	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRBP , a regulator of cellular PKR and HIV-1 virus expression , interacts with Dicer and functions in RNA silencing .
25702703	0	Dicer	0,5	cyclin_D1	82,91	Dicer	cyclin D1	23405	595	Gene	Gene	levels|amod|START_ENTITY requires|nsubj|levels requires|dobj|END_ENTITY	Dicer regulated let-7 expression levels in p53-induced cancer repression requires cyclin_D1 .
24220032	0	Dicer	21,26	p53	7,10	Dicer	p53	23405	7157	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Mutant p53 regulates Dicer through p63-dependent and - independent mechanisms to promote an invasive phenotype .
24979267	0	Dicer	0,5	p53	22,25	Dicer	p53	23405	22060(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Dicer cooperates with p53 to suppress DNA damage and skin_carcinogenesis in mice .
26294080	0	Dicer-1	66,73	MicroRNA-107	0,12	Dicer-1	MicroRNA-107	299284(Tax:10116)	100314022(Tax:10116)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1 .
22836445	0	Dicer1	0,6	Notch1	41,47	Dicer1	Notch1	192119(Tax:10090)	18128(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Dicer1 and MiR-9 are required for proper Notch1 signaling and the Bergmann glial phenotype in the developing mouse cerebellum .
22000856	0	Dickkopf	48,56	LRP5/6	68,74	Dickkopf	LRP5/6	22943	4041;4040	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6 .
18068158	0	Dickkopf-1	9,19	Kremen1	37,44	Dickkopf-1	Kremen1	13380(Tax:10090)	84035(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY END_ENTITY|nsubj|Roles	Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice .
17643814	0	Dickkopf-1	0,10	MYCN	32,36	Dickkopf-1	MYCN	22943	4613	Gene	Gene	down-regulated|nsubjpass|START_ENTITY down-regulated|nmod|END_ENTITY	Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation .
26407843	0	Dickkopf-1	32,42	P38	0,3	Dickkopf-1	P38	22943	1432	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	P38 regulates the Wnt inhibitor Dickkopf-1 in breast_cancer .
10777218	0	Dickkopf-1	0,10	p53	69,72	Dickkopf-1	p53	22943	7157	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Dickkopf-1 , an inhibitor of the Wnt signaling pathway , is induced by p53 .
22815877	0	Dickkopf-related_protein_1	43,69	DKK1	71,75	Dickkopf-related protein 1	DKK1	22943	22943	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genistein affects histone modifications on Dickkopf-related_protein_1 -LRB- DKK1 -RRB- gene in SW480 human colon_cancer cell line .
12421700	0	Dickkopf1	30,39	Kremen	0,6	Dickkopf1	Kremen	373592(Tax:8355)	398249(Tax:8355)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|proteins proteins|compound|END_ENTITY	Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning .
19936252	0	Dickkopf_1	27,37	Lrp4	0,4	Dickkopf 1	Lrp4	13380(Tax:10090)	228357(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Lrp4 , a novel receptor for Dickkopf_1 and sclerostin , is expressed by osteoblasts and regulates bone growth and turnover in vivo .
21546446	0	Dickkopf_1	23,33	Prokineticin_1	0,14	Dickkopf 1	Prokineticin 1	22943	84432	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Prokineticin_1 induces Dickkopf_1 expression and regulates cell proliferation and decidualization in the human endometrium .
1823952	0	Diego_blood-group	47,64	Dia	34,37	Diego blood-group	Dia	6521	1730	Gene	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	-LSB- Studies of occurrence of antigen Dia from the Diego_blood-group system in the Polish population -RSB- .
26710124	0	Differentially_Expressed_in_Chondrocytes_2	0,42	IL-1b	78,83	Differentially Expressed in Chondrocytes 2	IL-1b	79365	3553	Gene	Gene	Increases|nsubj|START_ENTITY Increases|dobj|Expression Expression|nmod|END_ENTITY	Differentially_Expressed_in_Chondrocytes_2 -LRB- DEC2 -RRB- Increases the Expression of IL-1b and Is Abundantly Present in Synovial Membrane in Rheumatoid_Arthritis .
26771602	0	Dihydropyrimidinase	81,100	DPYS	102,106	Dihydropyrimidinase	DPYS	1807	1807	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c. 1443 +5 G > A in the Dihydropyrimidinase -LRB- DPYS -RRB- Gene .
12775023	0	Dihydropyrimidine_dehydrogenase	0,31	DPD	33,36	Dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in gastric_cancer tissue and effect of DPD inhibitory fluoropyrimidines .
12775023	0	Dihydropyrimidine_dehydrogenase	0,31	DPD	86,89	Dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in gastric_cancer tissue and effect of DPD inhibitory fluoropyrimidines .
23603345	0	Dihydropyrimidine_dehydrogenase	0,31	DPYD	38,42	Dihydropyrimidine dehydrogenase	DPYD	1806	1806	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dihydropyrimidine_dehydrogenase gene -LRB- DPYD -RRB- polymorphism among Caucasian and non-Caucasian patients with 5-FU - and capecitabine-related toxicity using full sequencing of DPYD .
10024690	0	Dihydropyrimidine_dehydrogenase	0,31	multidrug_resistance-associated_protein	33,72	Dihydropyrimidine dehydrogenase	multidrug resistance-associated protein	1806	8714	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase , multidrug_resistance-associated_protein , and thymidylate_synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal_cancer cells .
26429885	0	Dilp8	73,78	Lgr3	90,94	Dilp8	Lgr3	39909(Tax:7227)	43098(Tax:7227)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3 .
26510564	0	Dilp8	0,5	Lgr3	45,49	Dilp8	Lgr3	39909(Tax:7227)	43098(Tax:7227)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing .
19757398	0	Dimethylarginine_Dimethylaminohydrolase_1	11,52	DDAH1	54,59	Dimethylarginine Dimethylaminohydrolase 1	DDAH1	23576	23576	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for Dimethylarginine_Dimethylaminohydrolase_1 -LRB- DDAH1 -RRB- in mammalian development .
16574895	0	Dimethylarginine_dimethylaminohydrolase_2	0,41	vascular_endothelial_growth_factor	52,86	Dimethylarginine dimethylaminohydrolase 2	vascular endothelial growth factor	23564	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Dimethylarginine_dimethylaminohydrolase_2 increases vascular_endothelial_growth_factor expression through Sp1 transcription factor in endothelial cells .
20403257	0	Ding	45,49	Lun	65,68	Ding	Lun	6045	10210	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Healthcare in marriage and pregnancy in Tai Ding Yang Sheng Zhu Lun -RSB- .
12972323	0	Dipeptidyl-peptidase_IV	90,113	Dpp4	84,88	Dipeptidyl-peptidase IV	Dpp4	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization , transmission , spontaneous mutations , and variation of function of the Dpp4 -LRB- Dipeptidyl-peptidase_IV ; CD26 -RRB- gene in rats .
26291537	0	Dipeptidyl_Peptidase-4	22,44	DPP4	46,50	Dipeptidyl Peptidase-4	DPP4	281122(Tax:9913)	281122(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of Inhibiting Dipeptidyl_Peptidase-4 -LRB- DPP4 -RRB- in Cows with Subclinical Ketosis .
26291537	0	Dipeptidyl_Peptidase-4	22,44	DPP4	46,50	Dipeptidyl Peptidase-4	DPP4	281122(Tax:9913)	281122(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of Inhibiting Dipeptidyl_Peptidase-4 -LRB- DPP4 -RRB- in Cows with Subclinical Ketosis .
25165473	0	Dipeptidyl_Peptidase-4	11,33	MK-0431	50,57	Dipeptidyl Peptidase-4	MK-0431	13482(Tax:10090)	1477734(Tax:190192)	Gene	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	Effects of Dipeptidyl_Peptidase-4 Inhibition with MK-0431 on Syngeneic Mouse Islet Transplantation .
26441982	0	Dipeptidyl_Peptidase-4	0,22	SDF-1	37,42	Dipeptidyl Peptidase-4	SDF-1	1803	6387	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Dipeptidyl_Peptidase-4 Regulation of SDF-1 / CXCR4 Axis : Implications for Cardiovascular_Disease .
23675206	0	Dipeptidyl_Peptidase_IV	44,67	IGF-1	35,40	Dipeptidyl Peptidase IV	IGF-1	1803	3479	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of Signaling-active IGF-1 by Dipeptidyl_Peptidase_IV -LRB- DPP-IV -RRB- .
22284242	0	Dipeptidyl_peptidase-4	0,22	DPP-4	24,29	Dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors are favourable to glucagon-like_peptide-1 -LRB- GLP-1 -RRB- agonists : no .
12715075	0	Dipeptidyl_peptidase_IV	0,23	CD26	25,29	Dipeptidyl peptidase IV	CD26	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- CD26 -RRB- activity in the hematopoietic system : differences between the membrane-anchored and the released enzyme activity .
9269038	0	Dipeptidyl_peptidase_IV	0,23	CD26	25,29	Dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- CD26 -RRB- activity in human alloreactive T cell subsets varies with the stage of differentiation and activation status .
21672052	0	Dipeptidyl_peptidase_IV	0,23	DPP4	25,29	Dipeptidyl peptidase IV	DPP4	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- DPP4 -RRB- deficiency increases Th1-driven allergic contact dermatitis .
15168326	0	Dipeptidyl_peptidase_IV	0,23	DPPIV	25,30	Dipeptidyl peptidase IV	DPPIV	100341424(Tax:9986)	100341424(Tax:9986)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- DPPIV -RRB- activity in the tear fluid as an indicator of the severity of corneal_injury : a histochemical and biochemical study .
7910536	0	Dipeptidyl_peptidase_IV	0,23	DP_IV	25,30	Dipeptidyl peptidase IV	DP IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dipeptidyl_peptidase_IV -LRB- DP_IV -RRB- activity in serum and on lymphocytes of MRL/Mp-lpr/lpr mice correlates with disease onset .
19073764	0	Dipeptidyl_peptidase_IV	0,23	MK0431	40,46	Dipeptidyl peptidase IV	MK0431	13482(Tax:10090)	1477734(Tax:190192)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Dipeptidyl_peptidase_IV inhibition with MK0431 improves islet graft survival in diabetic_NOD mice partially via T-cell modulation .
18025295	0	Dipeptidyl_peptidase_IV	0,23	angiotensin-converting_enzyme	27,56	Dipeptidyl peptidase IV	angiotensin-converting enzyme	1803	1636	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Dipeptidyl_peptidase_IV in angiotensin-converting_enzyme inhibitor associated angioedema .
16475979	0	Dipeptidyl_peptidases_8_and_9	0,29	dipeptidyl_peptidase_IV	88,111	Dipeptidyl peptidases 8 and 9	dipeptidyl peptidase IV	54878;91039	1803	Gene	Gene	START_ENTITY|dep|characterization characterization|nmod|END_ENTITY	Dipeptidyl_peptidases_8_and_9 : specificity and molecular characterization compared with dipeptidyl_peptidase_IV .
22284241	0	Dipeptidylpeptidase-4	0,21	DPP-4	23,28	Dipeptidylpeptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Dipeptidylpeptidase-4 -LRB- DPP-4 -RRB- inhibitors are favourable to glucagon-like_peptide-1 -LRB- GLP-1 -RRB- _ receptor agonists : yes .
26051627	0	Dipeptidylpeptidase_4	0,21	DPP4	23,27	Dipeptidylpeptidase 4	DPP4	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dipeptidylpeptidase_4 -LRB- DPP4 , CD26 -RRB- activity in the blood serum of term and preterm neonates with cerebral_ischemia .
2565342	0	Dipeptidylpeptidase_IV	0,22	growth_hormone-releasing_hormone	71,103	Dipeptidylpeptidase IV	growth hormone-releasing hormone	1803	2691	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	Dipeptidylpeptidase_IV and trypsin-like enzymatic degradation of human growth_hormone-releasing_hormone in plasma .
19931637	0	Disabled-1	79,89	Dab1	91,95	Disabled-1	Dab1	692351(Tax:7955)	692351(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterisation and differential expression during development of a duplicate Disabled-1 -LRB- Dab1 -RRB- gene from zebrafish .
12670700	0	Disabled-1	84,94	Reelin	20,26	Disabled-1	Reelin	13131(Tax:10090)	19699(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|Binding Binding|nmod|END_ENTITY	Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1 .
16481437	0	Disabled-1	73,83	Reelin	25,31	Disabled-1	Reelin	13131(Tax:10090)	19699(Tax:10090)	Gene	Gene	adaptor|compound|START_ENTITY dissection|nmod|adaptor dissection|nmod|END_ENTITY	Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein_E_receptor_2 : distinct roles in development and synaptic plasticity .
19796633	0	Disabled-1	61,71	Reelin	95,101	Disabled-1	Reelin	13131(Tax:10090)	19699(Tax:10090)	Gene	Gene	START_ENTITY|nmod|transmission transmission|nmod|signaling signaling|compound|END_ENTITY	Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling .
22394407	0	Disabled-1	95,105	Reelin	0,6	Disabled-1	Reelin	1600	5649	Gene	Gene	phosphorylation|compound|START_ENTITY signaling|nmod|phosphorylation regulates|advcl|signaling regulates|nsubj|END_ENTITY	Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation .
9716537	0	Disabled-1	0,10	Reelin	30,36	Disabled-1	Reelin	13131(Tax:10090)	5649	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain .
11247302	0	Disabled-2	0,10	AP-2	80,84	Disabled-2	AP-2	1601	7020	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 .
17922036	0	Disabled-2	26,36	Axin	82,86	Disabled-2	Axin	1601	8312	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	The inhibitory effects of Disabled-2 -LRB- Dab2 -RRB- on Wnt signaling are mediated through Axin .
11823414	0	Disabled-2	0,10	ICSBP	45,50	Disabled-2	ICSBP	13132(Tax:10090)	15900(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion .
11247302	0	Disabled-2	0,10	LDLR	32,36	Disabled-2	LDLR	1601	3949	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 .
19340093	0	Disabled-2	79,89	Megalin	0,7	Disabled-2	Megalin	79128(Tax:10116)	29216(Tax:10116)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Megalin and nonmuscle_myosin_heavy_chain_IIA interact with the adaptor protein Disabled-2 in proximal tubule cells .
12881709	0	Disabled-2	40,50	cdc2	54,58	Disabled-2	cdc2	1601	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell cycle-dependent phosphorylation of Disabled-2 by cdc2 .
25212232	0	Disabled-2	0,10	thrombin	75,83	Disabled-2	thrombin	13132(Tax:10090)	14061(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Disabled-2 is required for efficient hemostasis and platelet activation by thrombin in mice .
22832659	0	Disc1	41,46	Dixdc1	64,70	Disc1	Dixdc1	244667(Tax:10090)	330938(Tax:10090)	Gene	Gene	partner|amod|START_ENTITY partner|appos|END_ENTITY	Abnormal_behavior in mice mutant for the Disc1 binding partner , Dixdc1 .
19570850	0	Disc1	0,5	foxd3	16,21	Disc1	foxd3	407621(Tax:7955)	30548(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Disc1 regulates foxd3 and sox10 expression , affecting neural crest migration and differentiation .
25155634	0	Discoidin_domain_receptor_1	0,27	ZEB1	65,69	Discoidin domain receptor 1	ZEB1	780	6935	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Discoidin_domain_receptor_1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition .
11884411	0	Discoidin_domain_receptor_2	0,27	Src	43,46	Discoidin domain receptor 2	Src	4921	6714	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Discoidin_domain_receptor_2 interacts with Src and Shc following its activation by type I collagen .
19415460	0	Discoidin_domain_receptor_2	0,27	matrix_metalloproteinase-13	75,102	Discoidin domain receptor 2	matrix metalloproteinase-13	4921	4322	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|nmod|END_ENTITY	Discoidin_domain_receptor_2 is associated with the increased expression of matrix_metalloproteinase-13 in synovial fibroblasts of rheumatoid_arthritis .
11723120	0	Discoidin_domain_receptor_2	0,27	matrix_metalloproteinase-2	160,186	Discoidin domain receptor 2	matrix metalloproteinase-2	18214(Tax:10090)	17390(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Discoidin_domain_receptor_2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix_metalloproteinase-2 .
11941372	0	Dishevelled	21,32	Frodo	0,5	Dishevelled	Frodo	399301(Tax:8355)	398315(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Frodo interacts with Dishevelled to transduce Wnt signals .
17084360	0	Dishevelled	12,23	Frodo	0,5	Dishevelled	Frodo	399301(Tax:8355)	398315(Tax:8355)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Frodo links Dishevelled to the p120-catenin/Kaiso pathway : distinct catenin subfamilies promote Wnt signals .
24244865	0	Dishevelled	22,33	Nup358	0,6	Dishevelled	Nup358	8215	5903	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nup358 interacts with Dishevelled and aPKC to regulate neuronal polarity .
12842914	0	Dishevelled	27,38	PKC_delta	0,9	Dishevelled	PKC delta	399301(Tax:8355)	404226(Tax:8355)	Gene	Gene	function|compound|START_ENTITY essential|nmod|function essential|nsubj|END_ENTITY	PKC_delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements .
26399523	0	Dishevelled	29,40	PTEN	0,4	Dishevelled	PTEN	8215	5728	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PTEN regulates cilia through Dishevelled .
12907630	0	Dishevelled	52,63	beta-catenin	111,123	Dishevelled	beta-catenin	8215	1499	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|END_ENTITY	Wnt pathway activation in mesothelioma : evidence of Dishevelled overexpression and transcriptional activity of beta-catenin .
20628365	0	Dishevelled	0,11	p65	27,30	Dishevelled	p65	8215	5970	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dishevelled interacts with p65 and acts as a repressor of NF-kB-mediated transcription .
24234591	0	Dishevelled-1	0,13	Dvl-1	15,20	Dishevelled-1	Dvl-1	1855	1855	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Dishevelled-1 -LRB- Dvl-1 -RRB- protein : a potential participant of oxidative stress induced by selenium_deficiency .
23347445	0	Disrupted_in_Schizophrenia-1	39,67	DISC1	69,74	Disrupted in Schizophrenia-1	DISC1	27185	27185	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effects of the adverse life events and Disrupted_in_Schizophrenia-1 -LRB- DISC1 -RRB- gene polymorphisms on acute symptoms of schizophrenia .
9829980	0	Diva	0,4	Bcl-2	8,13	Diva	Bcl-2	10017	596	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Diva , a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death .
19706893	0	Divalent_metal_transporter_1	0,28	DMT1	30,34	Divalent metal transporter 1	DMT1	4891	4891	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Divalent_metal_transporter_1 -LRB- DMT1 -RRB- regulation by Ndfip1 prevents metal toxicity in human neurons .
19706893	0	Divalent_metal_transporter_1	0,28	Ndfip1	50,56	Divalent metal transporter 1	Ndfip1	4891	80762	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Divalent_metal_transporter_1 -LRB- DMT1 -RRB- regulation by Ndfip1 prevents metal toxicity in human neurons .
12183362	0	Diversin	27,35	Casein_kinase_Iepsilon	45,67	Diversin	Casein kinase Iepsilon	378477(Tax:7955)	43673(Tax:7227)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The ankyrin repeat protein Diversin recruits Casein_kinase_Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling .
20624590	0	Dixdc1	0,6	DISC1	34,39	Dixdc1	DISC1	85458	27185	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Dixdc1 is a critical regulator of DISC1 and embryonic cortical development .
20643344	0	Dixdc1	42,48	DISC1	10,15	Dixdc1	DISC1	85458	27185	Gene	Gene	selects|nsubj|START_ENTITY function|parataxis|selects function|nsubj|END_ENTITY	Switching DISC1 function in neurogenesis : Dixdc1 selects DISC1 binding partners .
20643344	0	Dixdc1	42,48	DISC1	57,62	Dixdc1	DISC1	85458	27185	Gene	Gene	selects|nsubj|START_ENTITY selects|dobj|partners partners|nummod|END_ENTITY	Switching DISC1 function in neurogenesis : Dixdc1 selects DISC1 binding partners .
22832659	0	Dixdc1	64,70	Disc1	41,46	Dixdc1	Disc1	330938(Tax:10090)	244667(Tax:10090)	Gene	Gene	partner|appos|START_ENTITY partner|amod|END_ENTITY	Abnormal_behavior in mice mutant for the Disc1 binding partner , Dixdc1 .
15242796	0	Dkk1	28,32	En1	0,3	Dkk1	En1	13380(Tax:10090)	13798(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	En1 and Wnt7a interact with Dkk1 during limb development in the mouse .
25231759	0	Dkk1	31,35	OTX2	16,20	Dkk1	OTX2	13380(Tax:10090)	18424(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Head formation : OTX2 regulates Dkk1 and Lhx1 activity in the anterior_mesendoderm .
25029272	0	Dkk3	33,37	Pax6	0,4	Dkk3	Pax6	50781(Tax:10090)	18508(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Pax6 regulates the expression of Dkk3 in murine and human cell lines , and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6 -LRB- 5a -RRB- isoform .
10051437	0	Dld	118,121	dihydrolipoamide_dehydrogenase	86,116	Dld	dihydrolipoamide dehydrogenase	13382(Tax:10090)	13382(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide_dehydrogenase -LRB- Dld -RRB- gene .
9169128	0	Dld	62,65	dihydrolipoamide_dehydrogenase	30,60	Dld	dihydrolipoamide dehydrogenase	13382(Tax:10090)	13382(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the mouse dihydrolipoamide_dehydrogenase -LRB- Dld -RRB- gene : genomic structure , promoter sequence , and chromosomal localization .
21791202	0	Dlg	29,32	Dlg	66,69	Dlg	Dlg	32083(Tax:7227)	32083(Tax:7227)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane .
21791202	0	Dlg	66,69	Dlg	29,32	Dlg	Dlg	32083(Tax:7227)	32083(Tax:7227)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane .
13679854	0	Dlg	105,108	MPP3	50,54	Dlg	MPP3	32083(Tax:7227)	4356	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Association of a lung_tumor suppressor TSLC1 with MPP3 , a human homologue of Drosophila_tumor suppressor Dlg .
17224403	0	Dlg	28,31	PAR-1_kinase	0,12	Dlg	PAR-1 kinase	32083(Tax:7227)	2768852(Tax:7227)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	PAR-1_kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction .
21791202	0	Dlg	29,32	adducin	11,18	Dlg	adducin	32083(Tax:7227)	37230(Tax:7227)	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane .
15485825	0	Dlg1	33,37	Delta1	17,23	Dlg1	Delta1	1739	8788	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration .
21041448	0	Dlg1	0,4	GKAP	11,15	Dlg1	GKAP	1739	9229	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Dlg1 binds GKAP to control dynein association with microtubules , centrosome positioning , and cell polarity .
25253337	0	Dlg1	10,14	phosphatidylinositol_3-kinase	29,58	Dlg1	phosphatidylinositol 3-kinase	1739	5293	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Hijacking Dlg1 for oncogenic phosphatidylinositol_3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins .
15289021	0	Dlk	30,33	delta-like	18,28	Dlk	delta-like	7786	7786	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of delta-like -LRB- Dlk -RRB- in a subset of myelodysplastic_syndrome bone marrow trephines .
25681392	0	Dlk-1	20,25	Copr5	70,75	Dlk-1	Copr5	13386(Tax:10090)	66423(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion .
24064361	0	Dlk1	0,4	Gli1	18,22	Dlk1	Gli1	114587(Tax:10116)	140589(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Dlk1 up-regulates Gli1 expression in male rat adrenal capsule cells through the activation of b1 integrin and ERK1/2 .
19515692	0	Dlk1	18,22	Nurr1	49,54	Dlk1	Nurr1	13386(Tax:10090)	18227(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Dlk1 , Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic_dopamine neurons .
22015720	0	Dll1	14,18	Cdx	0,3	Dll1	Cdx	13388(Tax:10090)	12590(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cdx regulates Dll1 in multiple lineages .
15908431	0	Dll1	15,19	MAGI1	0,5	Dll1	MAGI1	28514	9223	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface .
15986483	0	Dll1	0,4	Tbx6	31,35	Dll1	Tbx6	13388(Tax:10090)	21389(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Dll1 is a downstream target of Tbx6 in the paraxial mesoderm .
15153675	0	Dll3	79,83	delta_like_3	65,77	Dll3	delta like 3	13389(Tax:10090)	13389(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	New mutant mouse with skeletal_deformities caused by mutation in delta_like_3 -LRB- Dll3 -RRB- gene .
25130545	0	Dll4	109,113	ADAM10	38,44	Dll4	ADAM10	54567	102	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells .
17259973	0	Dll4	0,4	Notch1	24,30	Dll4	Notch1	54485(Tax:10090)	18128(Tax:10090)	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis .
11445007	0	Dlx-2	114,119	Bone_morphogenetic_protein-2	0,28	Dlx-2	Bone morphogenetic protein-2	13392(Tax:10090)	12156(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- signaling to the Col2alpha1 gene in chondroblasts requires the homeobox gene Dlx-2 .
17409112	0	Dlx1/2	52,58	MASH1	26,31	Dlx1/2	MASH1	1745;1746	429	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer .
18923043	0	Dlx2	26,30	Arx	0,3	Dlx2	Arx	1746	170302	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons .
11763998	0	Dlx2	27,31	PITX2	46,51	Dlx2	PITX2	1746	5308	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Antagonistic regulation of Dlx2 expression by PITX2 and Msx2 : implications for tooth development .
22885182	0	Dlx3	58,62	Akt1	0,4	Dlx3	Akt1	1747	207	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Akt1 regulates phosphorylation and osteogenic activity of Dlx3 .
11788714	0	Dlx3	52,56	Bone_morphogenetic_protein-2	0,28	Dlx3	Bone morphogenetic protein-2	13393(Tax:10090)	12156(Tax:10090)	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- transactivates Dlx3 through Smad1 and Smad4 : alternative mode for Dlx3 induction in mouse keratinocytes .
11788714	0	Dlx3	52,56	Smad1	65,70	Dlx3	Smad1	13393(Tax:10090)	17125(Tax:10090)	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nmod|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- transactivates Dlx3 through Smad1 and Smad4 : alternative mode for Dlx3 induction in mouse keratinocytes .
17164413	0	Dlx3	14,18	p63	35,38	Dlx3	p63	1747	8626	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Homeobox gene Dlx3 is regulated by p63 during ectoderm development : relevance in the pathogenesis of ectodermal_dysplasias .
19282665	0	Dlx3	20,24	p63	59,62	Dlx3	p63	1747	8626	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation .
19393622	0	Dlx5	41,45	Calmodulin-dependent_kinase_II	0,30	Dlx5	Calmodulin-dependent kinase II	1749	818	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Calmodulin-dependent_kinase_II regulates Dlx5 during osteoblast differentiation .
12459268	0	Dlx5	108,112	Runx2	145,150	Dlx5	Runx2	1749	860	Gene	Gene	distalless5|appos|START_ENTITY distalless5|appos|END_ENTITY	An L1 element disrupts human bone_sialoprotein promoter : lack of tissue-specific regulation by distalless5 -LRB- Dlx5 -RRB- and runt_homeodomain_protein2 -LRB- Runx2 -RRB- / core_binding_factor_a1 -LRB- Cbfa1 -RRB- elements .
12815054	0	Dlx5	46,50	Runx2	14,19	Dlx5	Runx2	13395(Tax:10090)	12393(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	BMP-2-induced Runx2 expression is mediated by Dlx5 , and TGF-beta_1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression .
16115867	0	Dlx5	0,4	Runx2	104,109	Dlx5	Runx2	1749	860	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|promoter promoter|amod|binding binding|nmod|elements elements|nmod|distal distal|amod|END_ENTITY	Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter .
16115867	0	Dlx5	0,4	Runx2	28,33	Dlx5	Runx2	1749	860	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter .
17335796	0	Dlx5	0,4	Runx2	12,17	Dlx5	Runx2	373969(Tax:9031)	373919(Tax:9031)	Gene	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|amod|END_ENTITY	Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme .
19934017	0	Dlx5	40,44	Shh	23,26	Dlx5	Shh	13395(Tax:10090)	20423(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft_palate in Msx1-null mice .
18326838	0	Dlx5	14,18	p63	47,50	Dlx5	p63	1749	8626	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital_limb_defects .
24692107	0	Dlx5	0,4	runx2	31,36	Dlx5	runx2	13395(Tax:10090)	12393(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|enhancer enhancer|amod|END_ENTITY	Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression .
21558373	0	Dlx6	27,31	Hand2	46,51	Dlx6	Hand2	13396(Tax:10090)	15111(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis .
19032147	0	DmTTF	125,130	DREF	30,34	DmTTF	DREF	34837(Tax:7227)	34328(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The Drosophila nuclear factor DREF positively regulates the expression of the mitochondrial_transcription_termination_factor DmTTF .
22761450	0	Dmc1	25,29	Tid1	78,82	Dmc1	Tid1	856926(Tax:4932)	852365(Tax:4932)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	Saccharomyces_cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins , respectively , to promote DNA strand invasion during genetic recombination .
10924480	0	Dmd	91,94	duchenne_muscular_dystrophy	57,84	Dmd	duchenne muscular dystrophy	1756	1756	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Contrasting evolutionary histories of two introns of the duchenne_muscular_dystrophy gene , Dmd , in humans .
7983353	0	Dmp1	57,61	AG1	52,55	Dmp1	AG1	1758	51060	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	In situ localization and chromosomal mapping of the AG1 -LRB- Dmp1 -RRB- gene .
17933869	0	Dmp53	47,52	Daxx-like_protein	0,17	Dmp53	Daxx-like protein	2768677(Tax:7227)	33906(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Daxx-like_protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level .
16506070	0	Dmrt-1	49,55	P450arom	17,25	Dmrt-1	P450arom	1761	1588	Gene	Gene	genes|compound|START_ENTITY Up-regulation|nmod|genes Up-regulation|nmod|END_ENTITY	Up-regulation of P450arom and down-regulation of Dmrt-1 genes in the temperature-dependent sex reversal from genetic males to phenotypic females in a salamander .
14673170	0	Dmrt1	37,42	Gata4	0,5	Dmrt1	Gata4	1761	2626	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Gata4 regulates testis expression of Dmrt1 .
9915854	0	DnaJ	111,115	Pituitary_tumor-transforming_gene	0,33	DnaJ	Pituitary tumor-transforming gene	10294	9232	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Pituitary_tumor-transforming_gene protein associates with ribosomal_protein_S10 and a novel human homologue of DnaJ in testicular cells .
11584023	0	DnaJ	2,6	apobec-1-binding_protein-2	16,42	DnaJ	apobec-1-binding protein-2	10294	51726	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	A DnaJ protein , apobec-1-binding_protein-2 , modulates apolipoprotein B mRNA editing .
11854491	0	DnaJ	10,14	hTid-1	24,30	DnaJ	hTid-1	85406	9093	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	The human DnaJ protein , hTid-1 , enhances binding of a multimer of the herpes_simplex_virus_type_1 UL9 protein to oris , an origin of viral DNA replication .
18845019	0	Dnm1	103,107	dynamin_1	87,96	Dnm1	dynamin 1	140694(Tax:10116)	140694(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Nicotine modulates expression of miR-140 * , which targets the 3 ' - untranslated region of dynamin_1 gene -LRB- Dnm1 -RRB- .
25941407	0	Dnm1p	60,65	Pex11p	32,38	Dnm1p	Pex11p	1759	854018(Tax:4932)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission .
11482456	0	Dnmt1	67,72	DNA_methyltransferase	44,65	Dnmt1	DNA methyltransferase	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Proliferation stage-dependent expression of DNA_methyltransferase -LRB- Dnmt1 -RRB- in mouse small intestine .
11942627	0	Dnmt1	37,42	DNA_methyltransferase	14,35	Dnmt1	DNA methyltransferase	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of DNA_methyltransferase -LRB- Dnmt1 -RRB- in testicular germ cells during development of mouse embryo .
12799438	0	Dnmt1	48,53	DNA_methyltransferase_1	23,46	Dnmt1	DNA methyltransferase 1	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	Transcription|appos|START_ENTITY Transcription|nmod|END_ENTITY	Transcription of mouse DNA_methyltransferase_1 -LRB- Dnmt1 -RRB- is regulated by both E2F-Rb-HDAC-dependent and - independent pathways .
22898998	0	Dnmt1	123,128	DNA_methyltransferase_1	98,121	Dnmt1	DNA methyltransferase 1	1786	1786	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MicroRNA-140 acts as a liver_tumor suppressor by controlling NF-kB activity by directly targeting DNA_methyltransferase_1 -LRB- Dnmt1 -RRB- expression .
22967183	0	Dnmt1	25,30	DNA_methyltransferase_1	0,23	Dnmt1	DNA methyltransferase 1	13433(Tax:10090)	13433(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	DNA_methyltransferase_1 -LRB- Dnmt1 -RRB- mutation affects Snrpn imprinting in the mouse male germ line .
22795133	0	Dnmt1	33,38	Oct4	0,4	Dnmt1	Oct4	1786	5460	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells .
12071960	0	Dnmt1	35,40	Sp1	49,52	Dnmt1	Sp1	13433(Tax:10090)	20683(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins .
26851214	0	Dnmt1	20,25	UHRF1	0,5	Dnmt1	UHRF1	30430(Tax:7955)	406350(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development .
17214966	0	Dnmt1-associated_protein_1	21,47	Bmi1	0,4	Dnmt1-associated protein 1	Bmi1	55929	648	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Bmi1 cooperates with Dnmt1-associated_protein_1 in gene silencing .
17713477	0	Dnmt3L	29,35	Dnmt3a	13,19	Dnmt3L	Dnmt3a	29947	1788	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation .
15105426	0	Dnmt3a	50,56	DNMT3L	0,6	Dnmt3a	DNMT3L	1788	29947	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	DNMT3L stimulates the DNA methylation activity of Dnmt3a and Dnmt3b through a direct interaction .
17713477	0	Dnmt3a	13,19	Dnmt3L	29,35	Dnmt3a	Dnmt3L	1788	29947	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation .
25801914	0	Dnmt3a	8,14	Kras	30,34	Dnmt3a	Kras	1788	3845	Gene	Gene	Loss|nmod|START_ENTITY END_ENTITY|nsubj|Loss	Loss of Dnmt3a and endogenous Kras -LRB- G12D / + -RRB- cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis .
25392496	0	Dnmt3a	0,6	Sim1	10,14	Dnmt3a	Sim1	13435(Tax:10090)	20464(Tax:10090)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis .
19509302	0	Dnmt3a	43,49	miR-29b	18,25	Dnmt3a	miR-29b	13435(Tax:10090)	407024	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos .
23409053	0	Dnmt3b	44,50	Dpp6	25,29	Dnmt3b	Dpp6	13436(Tax:10090)	13483(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells .
11735126	0	Dnmt3b	0,6	SUMO-1	54,60	Dnmt3b	SUMO-1	1789	7341	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dnmt3b , de novo DNA methyltransferase , interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1 .
22080864	0	Dock180	55,62	Rac1	14,18	Dock180	Rac1	330662(Tax:10090)	19353(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Activation of Rac1 by Src-dependent phosphorylation of Dock180 -LRB- Y1811 -RRB- mediates PDGFRa-stimulated glioma_tumorigenesis in mice and humans .
17027967	0	Dock4	0,5	RhoG	22,26	Dock4	RhoG	9732	391	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Dock4 is regulated by RhoG and promotes Rac-dependent cell migration .
23536706	0	Dock4	8,13	cortactin	29,38	Dock4	cortactin	9732	2017	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation .
23462102	0	Dock6	74,79	Akt	0,3	Dock6	Akt	319899(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Akt and PP2A reciprocally regulate the guanine_nucleotide exchange factor Dock6 to control axon growth of sensory neurons .
18426980	0	Dock7	45,50	ErbB2	0,5	Dock7	ErbB2	85440	2064	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration .
11825908	0	Dok-1	114,119	c-Kit	123,128	Dok-1	c-Kit	13448(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling .
15286081	0	Dok-6	0,5	p62	15,18	Dok-6	Ret	623279(Tax:10090)	19713(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Dok-6 , a Novel p62 Dok family member , promotes Ret-mediated neurite outgrowth .
19108574	0	Dok-7	0,5	MuSK	6,10	Dok-7	MuSK	285489	4593	Gene	Gene	/|nsubj|START_ENTITY /|dobj|signaling signaling|compound|END_ENTITY	Dok-7 / MuSK signaling and a congenital_myasthenic_syndrome .
19244212	0	Dok-7	0,5	MuSK	43,47	Dok-7	MuSK	285489	4593	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation .
24523872	0	Dok1	12,16	BRK	0,3	Dok1	BRK	1796	5753	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration .
15148308	0	Dok1	21,25	c-Abl	0,5	Dok1	c-Abl	13448(Tax:10090)	11350(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Abl phosphorylates Dok1 to promote filopodia during cell spreading .
25075100	0	Dok2	0,4	Klf1	27,31	Dok2	Klf1	13449(Tax:10090)	16596(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells .
20603078	0	Dok7	32,36	MuSK	76,80	Dok7	MuSK	285489	4593	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The cytoplasmic_adaptor protein Dok7 activates the receptor_tyrosine_kinase MuSK via dimerization .
20947765	0	Dom34	0,5	Hbs1	6,10	Dom34	Hbs1	855731(Tax:4932)	853959(Tax:4932)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Dom34 : Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay .
25274815	0	Dom3Z	36,41	EOL-1	0,5	Dom3Z	EOL-1	1797	6418775(Tax:6239)	Gene	Gene	Homolog|nmod|START_ENTITY END_ENTITY|appos|Homolog	EOL-1 , the Homolog of the Mammalian Dom3Z , Regulates Olfactory Learning in C. _ elegans .
8689588	0	Dominant_hemimelia	41,59	Dh	37,39	Dominant hemimelia	Dh	109698(Tax:10090)	109698(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Skeletal_malformations caused by the Dh -LRB- Dominant_hemimelia -RRB- gene in mice .
16301316	0	Dop1	57,61	Mon2	0,4	Dop1	Mon2	851719(Tax:4932)	855420(Tax:4932)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Mon2 , a relative of large Arf exchange factors , recruits Dop1 to the Golgi apparatus .
1145901	0	Dopamine-beta-hydroxylase	0,25	renin	37,42	Dopamine-beta-hydroxylase	renin	1621	5972	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Dopamine-beta-hydroxylase and plasma renin activity in twenty hypertensive subjects .
2965754	0	Dopamine_D-1_receptor	0,21	prolactin	45,54	Dopamine D-1 receptor	prolactin	1812	5617	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Dopamine_D-1_receptor agonist stimulation of prolactin secretion in man .
21707617	0	Dopamine_D1_receptor	0,20	ryanodine_receptor	48,66	Dopamine D1 receptor	ryanodine receptor	13488(Tax:10090)	20190(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Dopamine_D1_receptor signaling system regulates ryanodine_receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons .
11236830	0	Dopamine_D2_receptor	0,20	DRD2	27,31	Dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_D2_receptor gene -LRB- DRD2 -RRB- is associated with alcoholism with conduct_disorder .
7647164	0	Dopamine_D2_receptor	0,20	DRD2	27,31	Dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_D2_receptor gene -LRB- DRD2 -RRB- haplotypes and the defense style questionnaire in substance_abuse , Tourette_syndrome , and controls .
8874837	0	Dopamine_D2_receptor	0,20	DRD2	22,26	Dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_D2_receptor -LRB- DRD2 -RRB- gene and susceptibility to posttraumatic_stress_disorder : a study and replication .
8972908	0	Dopamine_D2_receptor	0,20	DRD2	27,31	Dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_D2_receptor gene -LRB- DRD2 -RRB- haplotypes in Caucasians .
24747168	0	Dopamine_D4_Receptor	4,24	DRD4	31,35	Dopamine D4 Receptor	DRD4	1815	1815	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	The Dopamine_D4_Receptor Gene -LRB- DRD4 -RRB- Moderates Cultural Difference in Independent Versus Interdependent Social Orientation .
11126393	0	Dopamine_D4_receptor	0,20	DRD4	22,26	Dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Dopamine_D4_receptor -LRB- DRD4 -RRB- gene polymorphism is associated with attachment disorganization in infants .
11354829	0	Dopamine_D4_receptor	0,20	DRD4	22,26	Dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Dopamine_D4_receptor -LRB- DRD4 -RRB- polymorphism and adaptability trait during infancy : a longitudinal study in 1 - to 5-month-old neonates .
26729744	0	Dopamine_Transporter	41,61	DAT1	68,72	Dopamine Transporter	DAT1	6531	6531	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Gene-Environment Correlation Between the Dopamine_Transporter Gene -LRB- DAT1 -RRB- Polymorphism and Childhood Experiences of Abuse .
12555232	0	Dopamine_beta-hydroxylase	0,25	DBH	27,30	Dopamine beta-hydroxylase	DBH	1621	1621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_beta-hydroxylase -LRB- DBH -RRB- gene and schizophrenia phenotypic variability : a genetic association study .
17853400	0	Dopamine_beta-hydroxylase	0,25	DBH	27,30	Dopamine beta-hydroxylase	DBH	1621	1621	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dopamine_beta-hydroxylase -LRB- DBH -RRB- activity and -1021 C/T polymorphism of DBH gene in combat-related post-traumatic_stress_disorder .
17157269	0	Dopamine_beta-hydroxylase	0,25	DbetaH	32,38	Dopamine beta-hydroxylase	DbetaH	1621	1621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_beta-hydroxylase gene -LRB- DbetaH -RRB- -1021 C -- > T influences self-reported paranoia during cocaine self-administration .
428086	0	Dopamine_beta-hydroxylase	0,25	renin	37,42	Dopamine beta-hydroxylase	renin	1621	5972	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Dopamine_beta-hydroxylase and plasma renin activity in patients with low - , normal - , and high-renin essential_hypertension .
23589621	0	Dopamine_receptor_D3	0,20	CD4	34,37	Dopamine receptor D3	CD4	13490(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|expressed expressed|nmod|cells cells|compound|END_ENTITY	Dopamine_receptor_D3 expressed on CD4 + T cells favors neurodegeneration of dopaminergic neurons during Parkinson 's _ disease .
15578612	0	Dopamine_receptor_D4	0,20	DRD4	22,26	Dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_receptor_D4 -LRB- DRD4 -RRB- gene in Han Chinese children with attention-deficit/hyperactivity _ disorder -LRB- ADHD -RRB- : increased prevalence of the 2-repeat allele .
11942948	0	Dopamine_transporter	0,20	DAT1	27,31	Dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_transporter gene -LRB- DAT1 -RRB- VNTR polymorphism in major psychiatric_disorders : family-based association study in the Bulgarian population .
17314918	0	Dopamine_transporter	0,20	DAT1	27,31	Dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dopamine_transporter gene -LRB- DAT1 -RRB- associated with appetite suppression to methylphenidate in a case-control study of binge_eating_disorder .
16680758	0	Doppel	23,29	Dpl	31,34	Doppel	Dpl	281426(Tax:9913)	281426(Tax:9913)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Bovine prion -LRB- PrP -RRB- and Doppel -LRB- Dpl -RRB- proteins expression after in vitro leukocyte activation or Dpl/PrP blocking .
17446686	0	Doppel	135,141	PrP	115,118	Doppel	PrP	26434(Tax:10090)	19122(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY END_ENTITY|appos|independent	Serum withdrawal-induced apoptosis in ZrchI prion_protein -LRB- PrP -RRB- gene-deficient neuronal cell line is suppressed by PrP , independent of Doppel .
15358521	0	Doppel	101,107	Prnd	80,84	Doppel	Prnd	26434(Tax:10090)	26434(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Identification of the critical cis-acting elements in the promoter of the mouse Prnd gene coding for Doppel protein .
16297464	0	Doppel	91,97	Prnd	70,74	Doppel	Prnd	26434(Tax:10090)	26434(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Involvement of upstream stimulatory factor in regulation of the mouse Prnd gene coding for Doppel protein .
15246873	0	Doppel	15,21	laminin_receptor_precursor_protein	43,77	Doppel	laminin receptor precursor protein	23627	3921	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Doppel with the full-length laminin_receptor_precursor_protein .
11306558	0	Doppel	98,104	prion_protein	74,87	Doppel	prion protein	26434(Tax:10090)	19122(Tax:10090)	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion_protein homologue Doppel .
15161660	0	Doppel	69,75	prion_protein	55,68	Doppel	prion protein	26434(Tax:10090)	19122(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Male_infertility and DNA damage in Doppel knockout and prion_protein / Doppel double-knockout mice .
18637555	0	Doublecortin	24,36	Dcx	38,41	Doublecortin	Dcx	13193(Tax:10090)	13193(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Postnatal expression of Doublecortin -LRB- Dcx -RRB- in the developing cerebellar cortex of mouse .
22649224	0	Doublecortin	0,12	neurofascin	43,54	Doublecortin	neurofascin	1641	23114	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|endocytosis endocytosis|nmod|END_ENTITY	Doublecortin -LRB- DCX -RRB- mediates endocytosis of neurofascin independently of microtubule binding .
9325060	0	Down_syndrome_candidate_region_1	82,114	DSCR1	75,80	Down syndrome candidate region 1	DSCR1	1827	1827	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization , alternative splicing , and expression patterns of the DSCR1 -LRB- Down_syndrome_candidate_region_1 -RRB- gene .
15263820	0	Down_syndrome_candidate_region_1	0,32	VEGF	56,60	Down syndrome candidate region 1	VEGF	1827	7422	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Down_syndrome_candidate_region_1 , a downstream target of VEGF , participates in endothelial cell migration and angiogenesis .
18197079	0	Down_syndrome_cell_adhesion_molecule	30,66	DSCAM	68,73	Down syndrome cell adhesion molecule	DSCAM	1826	1826	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association study between the Down_syndrome_cell_adhesion_molecule -LRB- DSCAM -RRB- gene and bipolar_disorder .
16516408	0	Down_syndrome_critical_region_gene_1-like_2	26,69	DSCR1L2	71,78	Down syndrome critical region gene 1-like 2	DSCR1L2	11123	11123	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Proteins encoded by human Down_syndrome_critical_region_gene_1-like_2 -LRB- DSCR1L2 -RRB- mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I -LRB- TNNI3 -RRB- .
24857398	0	Downstream_Regulatory_Element_Antagonistic_Modulator	21,73	DREAM	14,19	Downstream Regulatory Element Antagonistic Modulator	DREAM	56461(Tax:10090)	56461(Tax:10090)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of DREAM -LRB- Downstream_Regulatory_Element_Antagonistic_Modulator -RRB- , a Calcium-Binding Protein , Reduces L-DOPA-Induced Dyskinesias in Mice .
8668124	0	Dox-A2	145,151	diphenol_oxidase_A2	119,138	Dox-A2	diphenol oxidase A2	35176(Tax:7227)	35176(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A multicopy suppressor of nin1-1 of the yeast Saccharomyces_cerevisiae is a counterpart of the Drosophila_melanogaster diphenol_oxidase_A2 gene , Dox-A2 .
15728532	0	Dp1l1	36,41	Deleted_in_polyposis_1-like_1	0,29	Dp1l1	Deleted in polyposis 1-like 1	70335(Tax:10090)	70335(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deleted_in_polyposis_1-like_1 gene -LRB- Dp1l1 -RRB- : a novel gene richly expressed in retinal_ganglion cells .
15550398	0	Dp71	11,15	Sp1	72,75	Dp71	Sp1	13405(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY down-regulated|nsubjpass|expression down-regulated|nmod|myogenesis myogenesis|dep|role role|nmod|END_ENTITY	Dystrophin Dp71 expression is down-regulated during myogenesis : role of Sp1 and Sp3 on the Dp71 promoter activity .
15550398	0	Dp71	91,95	Sp1	72,75	Dp71	Sp1	13405(Tax:10090)	20683(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY down-regulated|nmod|activity down-regulated|nmod|myogenesis myogenesis|dep|role role|nmod|END_ENTITY	Dystrophin Dp71 expression is down-regulated during myogenesis : role of Sp1 and Sp3 on the Dp71 promoter activity .
19943855	0	Dp71	111,115	Sp1	91,94	Dp71	Sp1	13405(Tax:10090)	20683(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Induction of dystrophin Dp71 expression during neuronal differentiation : opposite roles of Sp1 and AP2alpha in Dp71 promoter activity .
19943855	0	Dp71	24,28	Sp1	91,94	Dp71	Sp1	13405(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|dep|roles roles|nmod|END_ENTITY	Induction of dystrophin Dp71 expression during neuronal differentiation : opposite roles of Sp1 and AP2alpha in Dp71 promoter activity .
17491017	0	Dpb4	4,8	ISW2	20,24	Dpb4	ISW2	851699(Tax:4932)	854480(Tax:4932)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA .
11159190	0	Dpc4	24,28	Madh4	30,35	Dpc4	Madh4	4089	4089	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Nuclear localization of Dpc4 -LRB- Madh4 , Smad4 -RRB- in colorectal_carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects .
24155890	0	Dpf3	39,43	STAT5	20,25	Dpf3	STAT5	8110	6776	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of a STAT5 target gene , Dpf3 , provides novel insights in chronic_lymphocytic_leukemia .
16680758	0	Dpl	31,34	Doppel	23,29	Dpl	Doppel	281426(Tax:9913)	281426(Tax:9913)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Bovine prion -LRB- PrP -RRB- and Doppel -LRB- Dpl -RRB- proteins expression after in vitro leukocyte activation or Dpl/PrP blocking .
18607068	0	Dpl	66,69	doppel	58,64	Dpl	doppel	23627	23627	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Altered cellular distribution and sub-cellular sorting of doppel -LRB- Dpl -RRB- protein in human astrocytoma cell lines .
7774018	0	Dpp	36,39	Schnurri	0,8	Dpp	Schnurri	33432(Tax:7227)	36171(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1 .
18555530	0	Dpp2	29,33	KLF2	68,72	Dpp2	KLF2	83768(Tax:10090)	16598(Tax:10090)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1 .
12972323	0	Dpp4	84,88	Dipeptidyl-peptidase_IV	90,113	Dpp4	Dipeptidyl-peptidase IV	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization , transmission , spontaneous mutations , and variation of function of the Dpp4 -LRB- Dipeptidyl-peptidase_IV ; CD26 -RRB- gene in rats .
23409053	0	Dpp6	25,29	Dnmt3b	44,50	Dpp6	Dnmt3b	13483(Tax:10090)	13436(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Epigenetic regulation of Dpp6 expression by Dnmt3b and its novel role in the inhibition of RA induced neuronal differentiation of P19 cells .
3890514	0	Dpp_II	41,47	dipeptidyl_peptidase_II	16,39	Dpp II	dipeptidyl peptidase II	83799(Tax:10116)	83799(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of dipeptidyl_peptidase_II -LRB- Dpp_II -RRB- in rat spinal cord .
21896782	0	Dppa2	28,33	ECAT15-2	19,27	Dppa2	ECAT15-2	73703(Tax:10090)	73703(Tax:10090)	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Essential roles of ECAT15-2 / Dppa2 in functional lung development .
19897479	0	Dpy-30	63,69	Sdc1	80,84	Dpy-30	Sdc1	84661	6382	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression .
11468292	0	Drac1	63,68	RotundRacGAP	34,46	Drac1	RotundRacGAP	38146(Tax:7227)	117503(Tax:7227)	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	The Rac GTPase-activating protein RotundRacGAP interferes with Drac1 and Dcdc42 signalling in Drosophila_melanogaster .
3045729	0	Dras3	60,65	rap1	12,16	Dras3	rap1	38244(Tax:7227)	38244(Tax:7227)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the ` effector ' region .
21957262	0	Draxin	0,6	DCC	61,64	Draxin	DCC	70433(Tax:10090)	13176(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Draxin inhibits axonal outgrowth through the netrin receptor DCC .
25444159	0	Drd3	29,33	NPAS2	67,72	Drd3	NPAS2	13490(Tax:10090)	18143(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2 .
19482058	0	Drd4	113,117	dopamine_receptor_D4	86,106	Drd4	dopamine receptor D4	25432(Tax:10116)	25432(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Thyroid_hormone and adrenergic signaling interact to control pineal expression of the dopamine_receptor_D4 gene -LRB- Drd4 -RRB- .
22761789	0	Dre-miR-2188	0,12	Nrp2a	21,26	Dre-miR-2188	Nrp2a	100628882	405901(Tax:7955)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos .
11375911	0	Dreher	34,40	Lmx1a	42,47	Dreher	Lmx1a	110648(Tax:10090)	110648(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Neuronal migration defects in the Dreher -LRB- Lmx1a -RRB- mutant mouse : role of disorders of the glial limiting membrane .
12065429	0	Drf1	0,4	Cdc7	43,47	Drf1	Cdc7	80174	8317	Gene	Gene	kinase|advmod|START_ENTITY kinase|nsubj|subunit subunit|nmod|END_ENTITY	Drf1 , a novel regulatory subunit for human Cdc7 kinase .
12897072	0	Drf1	8,12	Cdc7	29,33	Drf1	Cdc7	398696(Tax:8355)	398099(Tax:8355)	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Xenopus Drf1 , a regulator of Cdc7 , displays checkpoint-dependent accumulation on chromatin during an S-phase arrest .
17178897	0	Drg-1	37,42	activating_transcription_factor_3	76,109	Drg-1	activating transcription factor 3	13494(Tax:10090)	11910(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating_transcription_factor_3 in prostate_cancer .
23185031	0	Drg1	31,35	Rlp24	0,5	Drg1	Rlp24	4733	51187	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Rlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturation .
21340027	0	Drk	17,20	D-Cbl	0,5	Drk	D-Cbl	36497(Tax:7227)	38961(Tax:7227)	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis .
12021771	0	Dronc	49,54	DIAP1	4,9	Dronc	DIAP1	39173(Tax:7227)	39753(Tax:7227)	Gene	Gene	ubiquitination|nmod|START_ENTITY mediates|dobj|ubiquitination mediates|nsubj|finger finger|compound|END_ENTITY	The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis .
24185621	0	Drosha	58,64	EWS	26,29	Drosha	EWS	14000(Tax:10090)	14030(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	A multifunctional protein EWS regulates the expression of Drosha and microRNAs .
21674040	0	Drosha	77,83	Glycogen_synthase_kinase_3_beta	0,31	Drosha	Glycogen synthase kinase 3 beta	29102	2932	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Glycogen_synthase_kinase_3_beta -LRB- GSK3b -RRB- phosphorylates the RNAase III enzyme Drosha at S300 and S302 .
26971015	0	Drosha	76,82	p53	69,72	Drosha	p53	29102	7157	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Dysregulation of microRNA biogenesis in cancer : the impact of mutant p53 on Drosha complex activity .
10421372	0	Drosophila_Frizzled_2	22,43	Dally	0,5	Drosophila Frizzled 2	Dally	40090(Tax:7227)	39013(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Dally cooperates with Drosophila_Frizzled_2 to transduce Wingless signalling .
18779571	0	Drosophila_inhibitor_of_apoptosis_1	35,70	STAT92E	0,7	Drosophila inhibitor of apoptosis 1	STAT92E	39753(Tax:7227)	42428(Tax:7227)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	STAT92E is a positive regulator of Drosophila_inhibitor_of_apoptosis_1 -LRB- DIAP/1 -RRB- and protects against radiation-induced apoptosis .
22935001	0	Drosophila_insulin-like_peptide-6	0,33	dilp6	35,40	Drosophila insulin-like peptide-6	dilp6	31220(Tax:7227)	31220(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Drosophila_insulin-like_peptide-6 -LRB- dilp6 -RRB- expression from fat body extends lifespan and represses secretion of Drosophila_insulin-like_peptide-2 from the brain .
19385039	0	Drosophila_insulin-producing_cells_increases_insulin-like_peptide	44,109	DILP	111,115	Drosophila insulin-producing cells increases insulin-like peptide	DILP	2768992(Tax:7227)	2768992(Tax:7227)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Expression of human uncoupling protein-3 in Drosophila_insulin-producing_cells_increases_insulin-like_peptide -LRB- DILP -RRB- levels and shortens lifespan .
22885328	0	Drosulfakinin	0,13	CCKLR-17D1	24,34	Drosulfakinin	CCKLR-17D1	45845(Tax:7227)	32860(Tax:7227)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Drosulfakinin activates CCKLR-17D1 and promotes larval locomotion and escape response in Drosophila .
20147447	0	Drp1	34,38	Growth_factor_erv1-like	0,23	Drp1	Growth factor erv1-like	74006(Tax:10090)	11692(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Growth_factor_erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells .
21701560	0	Drp1	21,25	MIEF1	6,11	Drp1	MIEF1	10059	54471	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission .
23772688	0	Drp1	150,154	PINK1	40,45	Drp1	PINK1	10059	65018	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	The Parkinson 's _ disease-associated gene PINK1 protects neurons from ischemic_damage by decreasing mitochondrial translocation of the fission promoter Drp1 .
23284813	0	Drp1	60,64	TRAP1	0,5	Drp1	TRAP1	10059	10131	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression .
25767741	0	Drp1	57,61	dynamin-related_protein_1	30,55	Drp1	dynamin-related protein 1	10059	10059	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction with the effector dynamin-related_protein_1 -LRB- Drp1 -RRB- is an ancient function of Rab32 subfamily proteins .
24758576	0	Drp1	0,4	p53	16,19	Drp1	p53	114114(Tax:10116)	301300(Tax:10116)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo .
9245586	0	Drp2	48,52	dystrophin-related_protein_2	18,46	Drp2	dystrophin-related protein 2	13497(Tax:10090)	13497(Tax:10090)	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Expression of the dystrophin-related_protein_2 -LRB- Drp2 -RRB- transcript in the mouse .
24706946	0	Drs2p	36,41	Arl1p	74,79	Drs2p	Arl1p	851207(Tax:4932)	852462(Tax:4932)	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of the flippase Drs2p in modulating GTP hydrolysis of Arl1p .
25024375	0	DsbA-L	23,29	Sp1	74,77	DsbA-L	Sp1	76263(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Negative regulation of DsbA-L gene expression by the transcription factor Sp1 .
8040606	0	Dsg1	63,67	desmoglein_1	49,61	Dsg1	desmoglein 1	281131(Tax:9913)	281131(Tax:9913)	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The extracellular aminoterminal domain of bovine desmoglein_1 -LRB- Dsg1 -RRB- is recognized only by certain pemphigus foliaceus sera , whereas its intracellular domain is recognized by both pemphigus_vulgaris and pemphigus foliaceus sera .
26918609	0	Dsg2	47,51	EGFR	39,43	Dsg2	EGFR	1829	1956	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	c-Src/Cav1-dependent activation of the EGFR by Dsg2 .
26858977	0	Dsg3	13,17	Src	32,35	Dsg3	Src	1830	6714	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1 .
10949543	0	Dsg3	40,44	desmoglein_3	21,33	Dsg3	desmoglein 3	13512(Tax:10090)	13512(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the mouse desmoglein_3 gene -LRB- Dsg3 -RRB- : interspecies conservation within the cadherin superfamily .
19026775	0	Dsk2	35,39	Rpn10	0,5	Dsk2	Rpn10	29978	5710	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Rpn10 protects the proteasome from Dsk2 .
15837191	0	Dsk2p	31,36	UBA	17,20	Dsk2p	UBA	855319(Tax:4932)	855319(Tax:4932)	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|domain domain|compound|END_ENTITY	Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition .
9545272	0	Dspp	106,110	dentin_sialophosphoprotein	78,104	Dspp	dentin sialophosphoprotein	666279(Tax:10090)	666279(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization , chromosomal mapping , and promoter analysis of the mouse dentin_sialophosphoprotein -LRB- Dspp -RRB- gene , which codes for both dentin sialoprotein and dentin phosphoprotein .
9927667	0	Dss1	75,79	SEM1	0,4	Dss1	SEM1	855331(Tax:4932)	851967(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	SEM1 , a homologue of the split hand/split foot malformation candidate gene Dss1 , regulates exocytosis and pseudohyphal differentiation in yeast .
9218467	0	Dss4p	42,47	Sec4p	53,58	Dss4p	Sec4p	856128(Tax:4932)	850543(Tax:4932)	Gene	Gene	release|dobj|START_ENTITY release|nmod|END_ENTITY	Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast .
25477508	0	Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A	75,136	GSK3b	65,70	Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A	GSK3b	13548(Tax:10090)	56637(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation and Inactivation of Glycogen_Synthase_Kinase_3b -LRB- GSK3b -RRB- by Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A -LRB- Dyrk1A -RRB- .
25477508	0	Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A	75,136	Glycogen_Synthase_Kinase_3b	36,63	Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A	Glycogen Synthase Kinase 3b	13548(Tax:10090)	56637(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and Inactivation of Glycogen_Synthase_Kinase_3b -LRB- GSK3b -RRB- by Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A -LRB- Dyrk1A -RRB- .
25489104	0	Dual-specificity_phosphatase_5	0,30	ERK	49,52	Dual-specificity phosphatase 5	ERK	240672(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Dual-specificity_phosphatase_5 regulates nuclear ERK activity and suppresses skin_cancer by inhibiting mutant Harvey-Ras -LRB- HRasQ61L -RRB- - driven SerpinB2 expression .
25489104	0	Dual-specificity_phosphatase_5	0,30	Harvey-Ras	110,120	Dual-specificity phosphatase 5	Harvey-Ras	240672(Tax:10090)	15461(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|dobj|END_ENTITY	Dual-specificity_phosphatase_5 regulates nuclear ERK activity and suppresses skin_cancer by inhibiting mutant Harvey-Ras -LRB- HRasQ61L -RRB- - driven SerpinB2 expression .
25227984	0	Dual-specificity_phosphatase_6	0,30	CD4	41,44	Dual-specificity phosphatase 6	CD4	67603(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Dual-specificity_phosphatase_6 regulates CD4 -LRB- + -RRB- T-cell functions and restrains spontaneous_colitis in IL-10-deficient mice .
15694837	0	Dual-specificity_tyrosine-phosphorylated_and_regulated_kinase_1A	0,64	PAHX-AP1	147,155	Dual-specificity tyrosine-phosphorylated and regulated kinase 1A	PAHX-AP1	1859	9796	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dual-specificity_tyrosine-phosphorylated_and_regulated_kinase_1A -LRB- DYRK1A -RRB- interacts with the phytanoyl-CoA_alpha-hydroxylase associated protein 1 -LRB- PAHX-AP1 -RRB- , a brain specific protein .
25341110	0	Dual_Leucine_Zipper_Kinase	13,39	DLK	41,44	Dual leucine zipper kinase	DLK	7786	7786	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of Dual_Leucine_Zipper_Kinase -LRB- DLK , MAP3K12 -RRB- Inhibitors with Activity in Neurodegeneration Models .
24410844	0	Dual_oxidase_maturation_factor_1	0,32	DUOXA1	34,40	Dual oxidase maturation factor 1	DUOXA1	213696(Tax:10090)	213696(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Dual_oxidase_maturation_factor_1 -LRB- DUOXA1 -RRB- overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation .
21547253	0	Dual_specificity_phosphatase_1	0,30	inducible_nitric_oxide_synthase	47,78	Dual specificity phosphatase 1	inducible nitric oxide synthase	1843	4843	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Dual_specificity_phosphatase_1 regulates human inducible_nitric_oxide_synthase expression by p38 MAP kinase .
23276385	0	Dual_specificity_phosphatase_9	0,30	DUSP9	32,37	Dual specificity phosphatase 9	DUSP9	1852	1852	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dual_specificity_phosphatase_9 -LRB- DUSP9 -RRB- expression is down-regulated in the severe pre-eclamptic placenta .
20228808	0	Dub3	20,24	Cdc25A	74,80	Dub3	Cdc25A	377630	993	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A .
25244321	0	Duchenne_Muscular_Dystrophy	13,40	DMD	42,45	Duchenne Muscular Dystrophy	DMD	1756	1756	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Screening of Duchenne_Muscular_Dystrophy -LRB- DMD -RRB- Mutations and Investigating Its Mutational Mechanism in Chinese Patients .
3678494	0	Duchenne_muscular_dystrophy	32,59	Nebulin	0,7	Duchenne muscular dystrophy	Nebulin	1756	4703	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Nebulin and titin expression in Duchenne_muscular_dystrophy appears normal .
26473357	0	Duffy_Antigen_Receptor_for_Chemokines	76,113	DARC	115,119	Duffy Antigen Receptor for Chemokines	DARC	2532	2532	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Distinct Transcript Isoforms of the Atypical_Chemokine_Receptor_1 -LRB- ACKR1 -RRB- / Duffy_Antigen_Receptor_for_Chemokines -LRB- DARC -RRB- Gene Are Expressed in Lymphoblasts and Altered Isoform Levels Are Associated with Genetic Ancestry and the Duffy-Null Allele .
19822078	0	Duffy_antigen	17,30	MCP-1	121,126	Duffy antigen	MCP-1	2532	6347	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of the Duffy_antigen on pharmacokinetics and pharmacodynamics of recombinant monocyte chemoattractant protein -LRB- MCP-1 , CCL-2 -RRB- in vivo .
21156192	0	Duffy_antigen_receptor_for_chemokines	2,39	DARC	41,45	Duffy antigen receptor for chemokines	DARC	2532	2532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	A Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- polymorphism that determines pro-fibrotic chemokine serum concentrations is not directly associated with severity of hepatitis_C infection .
26045319	0	Duffy_antigen_receptor_for_chemokines	32,69	DARC	71,75	Duffy antigen receptor for chemokines	DARC	2532	2532	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Lack of association between the Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- expression and clinical outcome of children with sickle_cell_anemia .
26096170	0	Duffy_antigen_receptor_for_chemokines	14,51	DARC	53,57	Duffy antigen receptor for chemokines	DARC	2532	2532	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- is down-regulated in colorectal_cancer .
20199879	0	Duffy_antigen_receptor_for_chemokines	111,148	interleukin-8	10,23	Duffy antigen receptor for chemokines	interleukin-8	2532	3576	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of interleukin-8 and RANTES on the Gardos channel activity in sickle human red blood cells : role of the Duffy_antigen_receptor_for_chemokines .
18540090	0	Dun1	28,32	DIN7	47,51	Dun1	DIN7	851457(Tax:4932)	851856(Tax:4932)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage .
24958100	0	Dun1	6,10	Sml1	63,67	Dun1	Sml1	851457(Tax:4932)	854945(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron_deficiency .
17440044	0	Duox2	124,129	dual_oxidase_2	103,117	Duox2	dual oxidase 2	214593(Tax:10090)	214593(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Congenital_hypothyroidism , dwarfism , and hearing_impairment caused by a missense mutation in the mouse dual_oxidase_2 gene , Duox2 .
21321110	0	DuoxA2	147,153	dual_oxidase_A2	130,145	DuoxA2	dual oxidase A2	405753	405753	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Up-regulation and sustained activation of Stat1 are essential for interferon-gamma -LRB- IFN-gamma -RRB- - induced dual_oxidase_2 -LRB- Duox2 -RRB- and dual_oxidase_A2 -LRB- DuoxA2 -RRB- expression in human pancreatic_cancer cell lines .
16452319	0	Duplin	33,39	STAT3	15,20	Duplin	STAT3	67772(Tax:10090)	20848(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Suppression of STAT3 activity by Duplin , which is a negative regulator of the Wnt signal .
17164422	0	Dusp6	0,5	ERK	64,67	Dusp6	ERK	67603(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Dusp6 -LRB- Mkp3 -RRB- is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development .
23637337	0	Dusp6	15,20	Lef1	0,4	Dusp6	Lef1	353314(Tax:7955)	30701(Tax:7955)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium .
24234591	0	Dvl-1	15,20	Dishevelled-1	0,13	Dvl-1	Dishevelled-1	1855	1855	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Dishevelled-1 -LRB- Dvl-1 -RRB- protein : a potential participant of oxidative stress induced by selenium_deficiency .
26892600	0	Dvl2	64,68	CK1	58,61	Dvl2	CK1	1856	3848	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	DDX3 promotes tumor invasion in colorectal_cancer via the CK1 / Dvl2 axis .
22166206	0	Dvl2	16,20	Stau1	0,5	Dvl2	Stau1	1856	6780	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Stau1 regulates Dvl2 expression during myoblast differentiation .
17046997	0	Dynactin	0,8	Pavarotti-KLP	17,30	Dynactin	Pavarotti-KLP	39536(Tax:7227)	38515(Tax:7227)	Gene	Gene	targets|compound|START_ENTITY END_ENTITY|nsubj|targets	Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells .
25973308	0	Dynamin2	0,8	EGFR	31,35	Dynamin2	EGFR	1785	1956	Gene	Gene	delays|amod|START_ENTITY END_ENTITY|nsubj|delays	Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular_carcinoma .
17412836	0	Dynamin_2	0,9	Nef	66,69	Dynamin 2	Nef	1785	156110(Tax:11676)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Dynamin_2 is required for the enhancement of HIV-1 infectivity by Nef .
25263585	0	Dynamin_2	0,9	connexin_26	25,36	Dynamin 2	connexin 26	1785	2706	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dynamin_2 interacts with connexin_26 to regulate its degradation and function in gap junction formation .
15694365	0	Dynamin_II	0,10	syndecan-4	26,36	Dynamin II	syndecan-4	1785	6385	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dynamin_II interacts with syndecan-4 , a regulator of focal adhesion and stress-fiber formation .
11518709	0	Dyrk1	15,20	cAMP_response_element-binding_protein	31,68	Dyrk1	cAMP response element-binding protein	1859	1385	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Protein kinase Dyrk1 activates cAMP_response_element-binding_protein during neuronal differentiation in hippocampal progenitor cells .
22923366	0	Dyrk1A	0,6	ERK	50,53	Dyrk1A	ERK	13548(Tax:10090)	26413(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Dyrk1A , a serine/threonine kinase , is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice .
16959772	0	Dyrk1A	0,6	alpha-synuclein	22,37	Dyrk1A	alpha-synuclein	1859	6622	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation .
20696760	0	Dyrk1A	0,6	p53	22,25	Dyrk1A	p53	1859	7157	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells .
22178546	0	Dyrk1a	0,6	NQO1	29,33	Dyrk1a	NQO1	13548(Tax:10090)	18104(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf 2 dependent mechanism .
11756660	0	Dysadherin	0,10	E-cadherin	75,85	Dysadherin	E-cadherin	53827	999	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Dysadherin , a cancer-associated cell membrane glycoprotein , down-regulates E-cadherin and promotes metastasis .
22965940	0	Dysadherin	161,171	FXYD5	154,159	Dysadherin	FXYD5	53827	53827	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Let-7a down-regulation plays a role_in_thyroid_neoplasias of follicular histotype affecting cell adhesion and migration through its ability to target the FXYD5 -LRB- Dysadherin -RRB- gene .
20822372	0	Dysbindin	0,9	DTNBP1	16,22	Dysbindin	DTNBP1	84062	84062	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Dysbindin gene -LRB- DTNBP1 -RRB- in major depressive_disorder -LRB- MDD -RRB- patients : lack of association with clinical phenotypes .
24244862	0	Dysferlin	6,15	FER-1	0,5	Dysferlin	FER-1	26903(Tax:10090)	172659(Tax:6239)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	FER-1 / Dysferlin promotes cholinergic signaling at the neuromuscular junction in C. _ elegans and mice .
16010686	0	Dysferlin	0,9	LGMD2B	23,29	Dysferlin	LGMD2B	8291	8291	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Dysferlin mutations in LGMD2B , Miyoshi_myopathy , and atypical_dysferlinopathies .
24572254	0	Dysferlin	0,9	TRAF2	49,54	Dysferlin	TRAF2	26903(Tax:10090)	22030(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial_ischemia reperfusion injury .
15835269	0	Dysferlin	0,9	affixin	25,32	Dysferlin	affixin	8291	29780	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dysferlin interacts with affixin -LRB- beta-parvin -RRB- at the sarcolemma .
22174839	0	Dysferlin	0,9	histone_deacetylase_6	25,46	Dysferlin	histone deacetylase 6	8291	10013	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Dysferlin interacts with histone_deacetylase_6 and increases alpha-tubulin acetylation .
14749532	0	Dysferlin	0,9	p38	86,89	Dysferlin	p38	8291	26416(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Dysferlin in a hyperCKaemic patient with caveolin_3 mutation and in C2C12 cells after p38 MAP kinase inhibition .
21295953	0	Dystrobrevin-binding_protein_1	0,30	DTNBP1	37,43	Dystrobrevin-binding protein 1	DTNBP1	84062	84062	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dystrobrevin-binding_protein_1 gene -LRB- DTNBP1 -RRB- variants associated with cerebrospinal fluid homovanillic_acid and 5-hydroxyindoleacetic_acid concentrations in healthy volunteers .
24525189	0	Dystroglycan	43,55	miR-9a	11,17	Dystroglycan	miR-9a	36773(Tax:7227)	12797939	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Drosophila miR-9a targets the ECM receptor Dystroglycan to canalize myotendinous junction formation .
26974331	0	Dystrophin	40,50	Utrophin	15,23	Dystrophin	Utrophin	1756	7402	Gene	Gene	Complex|compound|START_ENTITY Levels|nmod|Complex Levels|compound|END_ENTITY	Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne_and_Becker_Muscular_Dystrophy Muscle Biopsies .
8186702	0	Dystrophin	0,10	utrophin	43,51	Dystrophin	utrophin	1756	7402	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Dystrophin and dystrophin-related protein -LRB- utrophin -RRB- distribution in normal and dystrophin-deficient_skeletal_muscles .
9447606	0	Dystrophin	0,10	utrophin	26,34	Dystrophin	utrophin	100355731(Tax:9986)	398351(Tax:8355)	Gene	Gene	replaced|nsubjpass|START_ENTITY replaced|nmod|END_ENTITY	Dystrophin is replaced by utrophin in frog heart ; implications for muscular_dystrophy .
19619587	0	Dyt1	105,109	c-fos	10,15	Dyt1	c-fos	30931(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in Dyt1 DeltaGAG knock-in mice .
10526234	0	E-APC	39,44	APC	100,103	E-APC	APC	42871(Tax:7227)	44642(Tax:7227)	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification and characterization of E-APC , a novel Drosophila homologue of the tumour suppressor APC .
26511190	0	E-CADHERIN	0,10	CDH1	24,28	E-CADHERIN	CDH1	999	999	Gene	Gene	GENE|compound|START_ENTITY GENE|appos|END_ENTITY	E-CADHERIN CODING GENE -LRB- CDH1 -RRB- AND NONSYNDROMIC CLEFT LIP WITH OR WITHOUT CLEFT PALATE : IS THERE ANY ASSOCIATION ?
7965405	0	E-CD	26,30	E-cadherin	14,24	E-CD	E-cadherin	999	999	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of E-cadherin -LRB- E-CD -RRB- as related to other prognostic factors and survival in breast_cancer .
19621455	0	E-Cadherin	75,85	CD56	69,73	E-Cadherin	CD56	999	4684	Gene	Gene	phenotype|dep|START_ENTITY phenotype|compound|END_ENTITY	Congenital_aggressive variant of Langerhans cells histiocytosis with CD56 + / E-Cadherin - phenotype .
20353702	0	E-Cadherin	73,83	CDH1	67,71	E-Cadherin	CDH1	999	999	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	-LSB- Gastric_carcinoma and chronic_gastritis : epigenetic regulation of CDH1 -LRB- E-Cadherin -RRB- , CDKN2A -LRB- p16INK4A -RRB- , PTGS2 -LRB- COX-2 -RRB- and EGFR genes through methylation -RSB- .
26287173	0	E-Cadherin	38,48	Cdc42-Interacting_Protein_4	0,27	E-Cadherin	Cdc42-Interacting Protein 4	12550(Tax:10090)	106628(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Cdc42-Interacting_Protein_4 Represses E-Cadherin Expression by Promoting b-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells .
20628524	0	E-Cadherin	12,22	Matrix_Metalloproteinase-7	26,52	E-Cadherin	Matrix Metalloproteinase-7	999	4316	Gene	Gene	Cleavage|nmod|START_ENTITY Cleavage|nmod|Proliferation Proliferation|compound|END_ENTITY	Cleavage of E-Cadherin by Matrix_Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA .
25896413	0	E-Cadherin	110,120	ZEB1	25,29	E-Cadherin	ZEB1	999	6935	Gene	Gene	Upregulation|nmod|START_ENTITY Invasiveness|nmod|Upregulation Targets|nmod|Invasiveness Targets|dobj|END_ENTITY	MiR-10b Directly Targets ZEB1 and PIK3CA to Curb Adenomyotic Epithelial Cell Invasiveness via Upregulation of E-Cadherin and Inhibition of Akt Phosphorylation .
17167724	0	E-Cadherin	62,72	beta-Catenin	48,60	E-Cadherin	beta-Catenin	999	1499	Gene	Gene	Transfection|amod|START_ENTITY Transfection|nmod|expression expression|nmod|END_ENTITY	Transfection of nm23-H1 increased expression of beta-Catenin , E-Cadherin and TIMP-1 and decreased the expression of MMP-2 , CD44v6_and_VEGF and inhibited the metastatic potential of human non-small_cell_lung_cancer cell line L9981 .
15922867	0	E-FABP	79,85	EpCAM	30,35	E-FABP	EpCAM	2171	4072	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	The tumour-associated antigen EpCAM upregulates the fatty_acid binding protein E-FABP .
9989799	0	E-MAP-115	35,44	epithelial_microtubule-associated_protein_of_115_kDa	46,98	E-MAP-115	epithelial microtubule-associated protein of 115 kDa	9053	9053	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|dep|END_ENTITY	Upregulation and redistribution of E-MAP-115 -LRB- epithelial_microtubule-associated_protein_of_115_kDa -RRB- in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts .
448070	0	E-RAF	40,45	E-rosette_augmenting_factor	11,38	E-RAF	E-rosette augmenting factor	51327	51327	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of E-rosette_augmenting_factor -LRB- E-RAF -RRB- after stimulation of human leukocytes with mitogens or antigens .
18811921	0	E-SOD	14,19	Cu/ZnSOD	56,64	E-SOD	Cu/ZnSOD	25352(Tax:10116)	24786(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of E-SOD , GPX5 mRNAs and immunoexpression of Cu/ZnSOD in epididymal epithelial cells of finasteride-treated rats .
16339541	0	E-Selectin	31,41	CD43	0,4	E-Selectin	CD43	20339(Tax:10090)	20737(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	CD43 functions as a ligand for E-Selectin on activated T cells .
21457936	0	E-Selectin	51,61	CD44	30,34	E-Selectin	CD44	6401	960	Gene	Gene	ligand|nmod|START_ENTITY contribution|nmod|ligand contribution|nmod|END_ENTITY	Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment .
23213466	0	E-Syt2	22,28	PAK1	70,74	E-Syt2	PAK1	57488	5058	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling .
9037311	0	E-cad	12,17	E-cadherin	0,10	E-cad	E-cadherin	999	999	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	E-cadherin -LRB- E-cad -RRB- expression in duct_carcinoma in situ -LRB- DCIS -RRB- of the breast .
15958533	0	E-cadherin	16,26	ADAM10	0,6	E-cadherin	ADAM10	12550(Tax:10090)	11487(Tax:10090)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion , migration , and beta-catenin translocation .
19603142	0	E-cadherin	36,46	ADAM10	103,109	E-cadherin	ADAM10	999	102	Gene	Gene	degradation|amod|START_ENTITY induce|dobj|degradation induce|advcl|activating activating|dobj|END_ENTITY	Human mesenchymal stem cells induce E-cadherin degradation in breast_carcinoma spheroids by activating ADAM10 .
24255666	0	E-cadherin	88,98	ADAM10	33,39	E-cadherin	ADAM10	999	102	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Upregulated expression levels of ADAM10 and EGFR and downregulated expression levels of E-cadherin in hepatocellular_carcinomas .
15969343	0	E-cadherin	15,25	Akt	33,36	E-cadherin	Akt	999	207	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	-LSB- Regulation of E-cadherin by the Akt protein kinase B -RSB- .
25261255	0	E-cadherin	75,85	Amphiregulin	0,12	E-cadherin	Amphiregulin	999	374	Gene	Gene	expression|amod|START_ENTITY induces|nmod|expression induces|nsubj|END_ENTITY	Amphiregulin induces human ovarian_cancer cell invasion by down-regulating E-cadherin expression .
17997862	0	E-cadherin	15,25	BMP-6	0,5	E-cadherin	BMP-6	999	654	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast_cancer cells .
14517842	0	E-cadherin	99,109	Beta-catenin	0,12	E-cadherin	Beta-catenin	999	1499	Gene	Gene	loss|nmod|START_ENTITY correlates|nmod|loss correlates|nsubj|accumulation accumulation|amod|END_ENTITY	Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53 , but not with expression of conventional WNT-1 target genes .
22718847	0	E-cadherin	93,103	CADM4	36,41	E-cadherin	CADM4	999	199731	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|expression expression|compound|END_ENTITY	Clinicopathological significance of CADM4 expression , and its correlation with expression of E-cadherin and Ki-67 in colorectal_adenocarcinomas .
15681774	0	E-cadherin	53,63	CCL25	0,5	E-cadherin	CCL25	999	6370	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	CCL25 enhances CD103-mediated lymphocyte adhesion to E-cadherin .
16930538	0	E-cadherin	14,24	CD24	53,57	E-cadherin	CD24	999	100133941	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of E-cadherin and TGF-beta3 expression by CD24 in cultured oral epithelial cells .
10072428	0	E-cadherin	9,19	CDH1	26,30	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Germline E-cadherin gene -LRB- CDH1 -RRB- mutations predispose to familial gastric_cancer and colorectal_cancer .
10896919	0	E-cadherin	4,14	CDH1	21,25	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The E-cadherin gene -LRB- CDH1 -RRB- variants T340A and L599V in gastric and colorectal_cancer patients in Korea .
11313896	0	E-cadherin	0,10	CDH1	17,21	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	E-cadherin gene -LRB- CDH1 -RRB- promoter methylation as the second hit in sporadic_diffuse_gastric_carcinoma .
11996968	0	E-cadherin	45,55	CDH1	62,66	E-cadherin	CDH1	999	999	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Characterization of DNA polymorphisms in the E-cadherin gene -LRB- CDH1 -RRB- promoter region .
12203775	0	E-cadherin	26,36	CDH1	43,47	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic control of the E-cadherin gene -LRB- CDH1 -RRB- by CpG methylation in colectomy samples of patients with ulcerative_colitis .
12579297	0	E-cadherin	22,32	CDH1	34,38	E-cadherin	CDH1	999	999	Gene	Gene	control|nmod|START_ENTITY control|appos|END_ENTITY	Epigenetic control of E-cadherin -LRB- CDH1 -RRB- by CpG methylation in metastasising laryngeal_cancer .
12604719	0	E-cadherin	41,51	CDH1	58,62	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ile-Leu substitution -LRB- I415L -RRB- in germline E-cadherin gene -LRB- CDH1 -RRB- in Japanese familial gastric_cancer .
12629411	0	E-cadherin	23,33	CDH1	35,39	E-cadherin	CDH1	999	999	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Hypermethylation of an E-cadherin -LRB- CDH1 -RRB- promoter region in high grade transitional cell carcinoma_of_the_bladder comprising carcinoma in situ .
14610318	0	E-cadherin	55,65	CDH1	72,76	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The G/A nucleotide change at cDNA position 2494 in the E-cadherin gene -LRB- CDH1 -RRB- : analysis in Italian patients .
14630673	0	E-cadherin	16,26	CDH1	33,37	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of the E-cadherin gene -LRB- CDH1 -RRB- in diffuse gastric_cancer susceptibility : from the laboratory to clinical practice .
16934975	0	E-cadherin	21,31	CDH1	33,37	E-cadherin	CDH1	999	999	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Polymorphisms in the E-cadherin -LRB- CDH1 -RRB- gene promoter and the risk of bladder_cancer .
17221870	0	E-cadherin	62,72	CDH1	74,78	E-cadherin	CDH1	999	999	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of seven novel germline mutations in the human E-cadherin -LRB- CDH1 -RRB- gene .
19398441	0	E-cadherin	17,27	CDH1	29,33	E-cadherin	CDH1	999	999	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms in E-cadherin -LRB- CDH1 -RRB- result in a mis-localised cytoplasmic protein that is associated with Crohn 's _ disease .
19781162	0	E-cadherin	17,27	CDH1	34,38	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Associations of E-cadherin gene -LRB- CDH1 -RRB- and hereditary_gastric_cancer in China -RSB- .
20632448	0	E-cadherin	15,25	CDH1	27,31	E-cadherin	CDH1	999	999	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of E-cadherin -LRB- CDH1 -RRB- gene polymorphisms and gastric_cancer risk .
21462191	0	E-cadherin	11,21	CDH1	23,27	E-cadherin	CDH1	999	999	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effects of E-cadherin -LRB- CDH1 -RRB- gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular_carcinoma .
21472888	0	E-cadherin	11,21	CDH1	23,27	E-cadherin	CDH1	999	999	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effects of E-cadherin -LRB- CDH1 -RRB- gene promoter polymorphisms on the risk and clinicopathologic development of oral_cancer .
21997289	0	E-cadherin	0,10	CDH1	12,16	E-cadherin	CDH1	999	999	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	E-cadherin -LRB- CDH1 -RRB- gene promoter polymorphism and the risk of colorectal_cancer : a meta-analysis .
22194161	0	E-cadherin	20,30	CDH1	32,36	E-cadherin	CDH1	999	999	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between E-cadherin -LRB- CDH1 -RRB- polymorphisms and papillary_thyroid_carcinoma risk in Han Chinese population .
25124632	0	E-cadherin	57,67	CDH1	51,55	E-cadherin	CDH1	999	999	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Loss of expression and aberrant methylation of the CDH1 -LRB- E-cadherin -RRB- gene in breast_cancer patients from Kashmir .
26191293	0	E-cadherin	20,30	CDH1	32,36	E-cadherin	CDH1	999	999	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between E-cadherin -LRB- CDH1 -RRB- polymorphisms and pancreatic_cancer risk in Han Chinese population .
26742007	0	E-cadherin	14,24	CDH1	8,12	E-cadherin	CDH1	999	999	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of CDH1 -LRB- E-cadherin -RRB- expression is associated with infiltrative tumour growth and lymph node metastasis .
9744472	0	E-cadherin	23,33	CDH1	35,39	E-cadherin	CDH1	999	999	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations of the human E-cadherin -LRB- CDH1 -RRB- gene .
23156733	0	E-cadherin	24,34	CGRP	12,16	E-cadherin	CGRP	999	796	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of CGRP on the E-cadherin expression in human bronchial epithelial cells -RSB- .
21335003	0	E-cadherin	15,25	COX-2	33,38	E-cadherin	COX-2	999	4513	Gene	Gene	VEGF|compound|START_ENTITY Correlation|nmod|VEGF END_ENTITY|nsubj|Correlation	Correlation of E-cadherin , VEGF , COX-2 expression to prognostic parameters in papillary_thyroid_carcinoma .
23670240	0	E-cadherin	16,26	COX-2	0,5	E-cadherin	COX-2	999	5743	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	COX-2 regulates E-cadherin expression through the NF-kB/Snail signaling pathway in gastric_cancer .
16943193	0	E-cadherin	23,33	Calreticulin	0,12	E-cadherin	Calreticulin	999	811	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug .
23724143	0	E-cadherin	20,30	Contactin-1	0,11	E-cadherin	Contactin-1	999	1272	Gene	Gene	expression|amod|START_ENTITY reduces|dobj|expression reduces|nsubj|END_ENTITY	Contactin-1 reduces E-cadherin expression via activating AKT in lung_cancer .
24887090	0	E-cadherin	15,25	Cox-2	50,55	E-cadherin	Cox-2	999	5743	Gene	Gene	expression|amod|START_ENTITY Restoration|nmod|expression Restoration|nmod|inhibition inhibition|compound|END_ENTITY	Restoration of E-cadherin expression by selective Cox-2 inhibition and the clinical relevance of the epithelial-to-mesenchymal transition in head_and_neck_squamous_cell_carcinoma .
17530268	0	E-cadherin	53,63	Cyclooxygenase-2	13,29	E-cadherin	Cyclooxygenase-2	999	5743	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	DNA content , Cyclooxygenase-2 expression and loss of E-cadherin expression do not predict risk of malignant_transformation_in_oral_lichen_planus .
19940363	0	E-cadherin	40,50	Cyclooxygenase-2	0,16	E-cadherin	Cyclooxygenase-2	999	5743	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Cyclooxygenase-2 mediated regulation of E-cadherin occurs in conventional but not early-onset gastric_cancer cell lines .
23376848	0	E-cadherin	27,37	DLC1	0,4	E-cadherin	DLC1	999	10395	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	DLC1 induces expression of E-cadherin in prostate_cancer cells through Rho pathway and suppresses invasion .
18164808	0	E-cadherin	45,55	DNA_methyltransferase_1_and_3b	85,115	E-cadherin	DNA methyltransferase 1 and 3b	999	1789	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	Hepatitis_C virus core protein downregulates E-cadherin expression via activation of DNA_methyltransferase_1_and_3b .
15674322	0	E-cadherin	43,53	DeltaEF1	0,8	E-cadherin	DeltaEF1	999	6935	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast_cancer cells .
21151980	0	E-cadherin	38,48	Desmoglein_3	0,12	E-cadherin	Desmoglein 3	999	1830	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Desmoglein_3 , via an interaction with E-cadherin , is associated with activation of Src .
11756660	0	E-cadherin	75,85	Dysadherin	0,10	E-cadherin	Dysadherin	999	53827	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	Dysadherin , a cancer-associated cell membrane glycoprotein , down-regulates E-cadherin and promotes metastasis .
7965405	0	E-cadherin	14,24	E-CD	26,30	E-cadherin	E-CD	999	999	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of E-cadherin -LRB- E-CD -RRB- as related to other prognostic factors and survival in breast_cancer .
9037311	0	E-cadherin	0,10	E-cad	12,17	E-cadherin	E-cad	999	999	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	E-cadherin -LRB- E-cad -RRB- expression in duct_carcinoma in situ -LRB- DCIS -RRB- of the breast .
15736420	0	E-cadherin	140,150	E-cadherin	34,44	E-cadherin	E-cadherin	999	999	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|nmod|END_ENTITY	Immunohistochemical expression of E-cadherin and beta-catenin in the normal and malignant human endometrium : an inverse correlation between E-cadherin and nuclear beta-catenin expression .
15736420	0	E-cadherin	34,44	E-cadherin	140,150	E-cadherin	E-cadherin	999	999	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Immunohistochemical expression of E-cadherin and beta-catenin in the normal and malignant human endometrium : an inverse correlation between E-cadherin and nuclear beta-catenin expression .
18931551	0	E-cadherin	0,10	E-cadherin	58,68	E-cadherin	E-cadherin	999	999	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	E-cadherin tissue expression and urinary soluble forms of E-cadherin in patients with bladder_transitional_cell_carcinoma .
18931551	0	E-cadherin	58,68	E-cadherin	0,10	E-cadherin	E-cadherin	999	999	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	E-cadherin tissue expression and urinary soluble forms of E-cadherin in patients with bladder_transitional_cell_carcinoma .
7957569	0	E-cadherin	14,24	E-cadherin	52,62	E-cadherin	E-cadherin	12550(Tax:10090)	12550(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of E-cadherin by murine dendritic cells : E-cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells .
7957569	0	E-cadherin	52,62	E-cadherin	14,24	E-cadherin	E-cadherin	12550(Tax:10090)	12550(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of E-cadherin by murine dendritic cells : E-cadherin as a dendritic cell differentiation antigen characteristic of epidermal Langerhans cells and related cells .
19199298	0	E-cadherin	100,110	EC1	80,83	E-cadherin	EC1	999	4819	Gene	Gene	role|nmod|START_ENTITY role|nmod|stability stability|nmod|domain domain|compound|END_ENTITY	The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin .
22531851	0	E-cadherin	45,55	EC1	31,34	E-cadherin	EC1	999	4819	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue .
26728967	0	E-cadherin	69,79	EC1	55,58	E-cadherin	EC1	999	4819	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Probing the interaction between cHAVc3 peptide and the EC1 domain of E-cadherin using NMR and molecular_dynamics simulations .
25758127	0	E-cadherin	93,103	EHD2	44,48	E-cadherin	EHD2	999	30846	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|nmod|END_ENTITY	Decreased expression and prognostic role of EHD2 in human breast_carcinoma : correlation with E-cadherin .
20101232	0	E-cadherin	41,51	ERalpha	0,7	E-cadherin	ERalpha	999	2099	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	ERalpha signaling through slug regulates E-cadherin and EMT .
18806826	0	E-cadherin	14,24	EZH2	55,59	E-cadherin	EZH2	999	2146	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|END_ENTITY	Repression of E-cadherin by the polycomb group protein EZH2 in cancer .
26897964	0	E-cadherin	42,52	EZH2	0,4	E-cadherin	EZH2	999	2146	Gene	Gene	Expression|compound|START_ENTITY Mediates|nmod|Expression Mediates|nsubj|END_ENTITY	EZH2 Mediates the Regulation of S100A4 on E-cadherin Expression and the Proliferation , Migration of Gastric_Cancer Cells .
21184735	0	E-cadherin	24,34	HDAC1	15,20	E-cadherin	HDAC1	999	3065	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Involvement of HDAC1 in E-cadherin expression in prostate_cancer cells ; its implication for cell motility and invasion .
22147512	0	E-cadherin	104,114	HDAC1	36,41	E-cadherin	HDAC1	999	3065	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|Recruitment Recruitment|nmod|END_ENTITY	Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic_cancer .
19737479	0	E-cadherin	24,34	IL-18	15,20	E-cadherin	IL-18	999	3606	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The effect of IL-18 on E-cadherin expression and its possible intracellular pathway in HK-2 cells -RSB- .
18773488	0	E-cadherin	33,43	Integrin-linked_kinase	0,22	E-cadherin	Integrin-linked kinase	999	3611	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Integrin-linked_kinase regulates E-cadherin expression through PARP-1 .
20375073	0	E-cadherin	14,24	K-Ras	39,44	E-cadherin	K-Ras	999	3845	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of E-cadherin expression by K-Ras ; involvement of DNA_methyltransferase-3b .
16702959	0	E-cadherin	0,10	KLF6	52,56	E-cadherin	KLF6	999	1316	Gene	Gene	target|nsubj|START_ENTITY target|nmod|suppressor suppressor|compound|END_ENTITY	E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor .
19604491	0	E-cadherin	57,67	KLRG1	42,47	E-cadherin	KLRG1	999	10219	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition .
17804733	0	E-cadherin	21,31	Kallikrein_6	0,12	E-cadherin	Kallikrein 6	999	19144(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Kallikrein_6 induces E-cadherin shedding and promotes cell proliferation , migration , and invasion .
22024768	0	E-cadherin	64,74	MAD1	31,35	E-cadherin	MAD1	999	8379	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The spindle checkpoint protein MAD1 regulates the expression of E-cadherin and prevents cell migration .
18062285	0	E-cadherin	26,36	MMP-2	19,24	E-cadherin	MMP-2	999	4313	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression of MMP-2 , E-cadherin in supraglottic_carcinoma and their relationship with cervical lymph node metastasis -RSB- .
21528083	0	E-cadherin	21,31	MSH2	15,19	E-cadherin	MSH2	999	4436	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
10936671	0	E-cadherin	68,78	Membrane_type_1-matrix_metalloproteinase	0,40	E-cadherin	Membrane type 1-matrix metalloproteinase	999	4323	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Membrane_type_1-matrix_metalloproteinase expression is regulated by E-cadherin through the suppression of mitogen-activated protein kinase cascade .
22752005	0	E-cadherin	79,89	MiR-23a	0,7	E-cadherin	MiR-23a	999	407010	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-23a regulates TGF-b-induced epithelial-mesenchymal transition by targeting E-cadherin in lung_cancer cells .
26990571	0	E-cadherin	19,29	MiR-301a	0,8	E-cadherin	MiR-301a	999	407027	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-301a regulates E-cadherin expression and is predictive of prostate_cancer recurrence .
10545506	0	E-cadherin	78,88	N-cadherin	0,10	E-cadherin	N-cadherin	999	1000	Gene	Gene	expression|amod|START_ENTITY regardless|nmod|expression promotes|advmod|regardless promotes|nsubj|END_ENTITY	N-cadherin promotes motility in human breast_cancer cells regardless of their E-cadherin expression .
15252840	0	E-cadherin	31,41	N-cadherin	17,27	E-cadherin	N-cadherin	999	1000	Gene	Gene	colon_cancers|amod|START_ENTITY Neoexpression|nmod|colon_cancers Neoexpression|nmod|END_ENTITY	Neoexpression of N-cadherin in E-cadherin positive colon_cancers .
16132038	0	E-cadherin	39,49	N-cadherin	64,74	E-cadherin	N-cadherin	999	1000	Gene	Gene	domain|nmod|START_ENTITY Influence|nmod|domain Influence|nmod|expression expression|amod|END_ENTITY	Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant_melanoma .
18056176	0	E-cadherin	14,24	N-cadherin	28,38	E-cadherin	N-cadherin	999	1000	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate_cancer .
20534673	0	E-cadherin	43,53	N-cadherin	0,10	E-cadherin	N-cadherin	12550(Tax:10090)	12558(Tax:10090)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation .
21822911	0	E-cadherin	111,121	N-cadherin	123,133	E-cadherin	N-cadherin	999	1000	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of TWIST decreases migration and invasion of laryngeal_carcinoma Hep-2 cells by regulating the E-cadherin , N-cadherin expression .
22696497	0	E-cadherin	0,10	N-cadherin	32,42	E-cadherin	N-cadherin	12550(Tax:10090)	12558(Tax:10090)	Gene	Gene	and|compound|START_ENTITY promotes|nsubj|and promotes|nsubj|END_ENTITY	E-cadherin and , in its absence , N-cadherin promotes Nanog expression in mouse embryonic stem cells via STAT3 phosphorylation .
24091815	0	E-cadherin	76,86	N-cadherin	0,10	E-cadherin	N-cadherin	999	1000	Gene	Gene	Expression|compound|START_ENTITY Associated|nmod|Expression Associated|nsubj|Expression Expression|compound|END_ENTITY	N-cadherin Expression in Feline Mammary_Tumors Is Associated With a Reduced E-cadherin Expression and the Presence of Regional Metastasis .
25014356	0	E-cadherin	0,10	N-cadherin	23,33	E-cadherin	N-cadherin	12550(Tax:10090)	12558(Tax:10090)	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	E-cadherin can replace N-cadherin during secretory-stage enamel development .
25438959	0	E-cadherin	46,56	N-cadherin	8,18	E-cadherin	N-cadherin	999	1000	Gene	Gene	expression|amod|START_ENTITY loss|nmod|expression associated|nmod|loss associated|nsubjpass|Loss Loss|nmod|END_ENTITY	Loss of N-cadherin is associated with loss of E-cadherin expression and poor outcomes of liver resection in hepatocellular_carcinoma .
26792846	0	E-cadherin	0,10	N-cadherin	12,22	E-cadherin	N-cadherin	999	1000	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	E-cadherin , N-cadherin Expression and Histologic Characterization of Canine Choroid_Plexus_Tumors .
23900729	0	E-cadherin	27,37	NDRG2	0,5	E-cadherin	NDRG2	999	57447	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon_cancer patients .
16862183	0	E-cadherin	20,30	NF-kappaB	0,9	E-cadherin	NF-kappaB	999	4790	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	NF-kappaB represses E-cadherin expression and enhances epithelial_to_mesenchymal_transition of mammary epithelial cells : potential involvement of ZEB-1 and ZEB-2 .
17047063	0	E-cadherin	0,10	Nanos1	27,33	E-cadherin	Nanos1	999	340719	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	E-cadherin regulates human Nanos1 , which interacts with p120ctn and induces tumor cell migration and invasion .
24738865	0	E-cadherin	34,44	Netrin-1	0,8	E-cadherin	Netrin-1	12550(Tax:10090)	18208(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY induces|dobj|degradation induces|nsubj|END_ENTITY	Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCa and FAK/Fyn in promoting mesenchymal stem cell motility .
25413347	0	E-cadherin	79,89	Nostrin	57,64	E-cadherin	Nostrin	37386(Tax:7227)	8673992(Tax:7227)	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in regulating E-cadherin in epithelial morphogenesis .
25829514	0	E-cadherin	86,96	Nostrin	57,64	E-cadherin	Nostrin	999	115677	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis .
25777441	0	E-cadherin	29,39	Nuclear_factor_I-C	0,18	E-cadherin	Nuclear factor I-C	999	4782	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Nuclear_factor_I-C regulates E-cadherin via control of KLF4 in breast_cancer .
25879941	0	E-cadherin	29,39	Nuclear_factor_I-C	0,18	E-cadherin	Nuclear factor I-C	999	4782	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Nuclear_factor_I-C regulates E-cadherin via control of KLF4 in breast_cancer .
25879941	0	E-cadherin	29,39	Nuclear_factor_I-C	0,18	E-cadherin	Nuclear factor I-C	999	4782	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Nuclear_factor_I-C regulates E-cadherin via control of KLF4 in breast_cancer .
24060241	0	E-cadherin	76,86	Oncostatin_M	0,12	E-cadherin	Oncostatin M	999	5008	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Oncostatin_M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation .
11205306	0	E-cadherin	20,30	P120ctn	46,53	E-cadherin	P120ctn	12550(Tax:10090)	12388(Tax:10090)	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of E-cadherin , beta-catenin , P120ctn in patients with transitional cell bladder_cancer .
18773488	0	E-cadherin	33,43	PARP-1	63,69	E-cadherin	PARP-1	999	142	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Integrin-linked_kinase regulates E-cadherin expression through PARP-1 .
24316392	0	E-cadherin	18,28	PLC	52,55	E-cadherin	PLC	999	3339	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	A new PKCa/b/TBX3 / E-cadherin pathway is involved in PLC - regulated invasion and migration in human bladder_cancer cells .
17015477	0	E-cadherin	59,69	Peroxisome_proliferator-activated_receptor_gamma	0,48	E-cadherin	Peroxisome proliferator-activated receptor gamma	12550(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma regulates E-cadherin expression and inhibits growth and invasion of prostate_cancer .
23045246	0	E-cadherin	99,109	Prospero_homeobox_1	0,19	E-cadherin	Prospero homeobox 1	999	5629	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	Prospero_homeobox_1 promotes epithelial-mesenchymal transition in colon_cancer cells by inhibiting E-cadherin via miR-9 .
12107059	0	E-cadherin	56,66	Protein_kinase_C	0,16	E-cadherin	Protein kinase C	999	112476	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Protein_kinase_C regulates endocytosis and recycling of E-cadherin .
11294891	0	E-cadherin	57,67	RAC1	0,4	E-cadherin	RAC1	999	5879	Gene	Gene	endocytosis|nmod|START_ENTITY regulates|nmod|endocytosis regulates|nsubj|END_ENTITY	RAC1 regulates adherens junctions through endocytosis of E-cadherin .
15689490	0	E-cadherin	80,90	Rab11	0,5	E-cadherin	Rab11	442858(Tax:9615)	403957(Tax:9615)	Gene	Gene	transport|nmod|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin .
18579802	0	E-cadherin	64,74	Rab11	7,12	E-cadherin	Rab11	442858(Tax:9615)	403957(Tax:9615)	Gene	Gene	trafficking|amod|START_ENTITY required|nmod|trafficking required|nsubjpass|END_ENTITY	Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis .
25117932	0	E-cadherin	16,26	Rab11	0,5	E-cadherin	Rab11	999	8766	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rab11 regulates E-cadherin expression and induces cell transformation in colorectal_carcinoma .
15689411	0	E-cadherin	25,35	Rac1	52,56	E-cadherin	Rac1	999	5879	Gene	Gene	trafficking|nmod|START_ENTITY regulated|nsubjpass|trafficking regulated|nmod|END_ENTITY	Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells .
16682529	0	E-cadherin	0,10	Rac1	51,55	E-cadherin	Rac1	83502(Tax:10116)	363875(Tax:10116)	Gene	Gene	engagement|amod|START_ENTITY stimulates|nsubj|engagement stimulates|dobj|proliferation proliferation|nmod|END_ENTITY	E-cadherin engagement stimulates proliferation via Rac1 .
19584084	0	E-cadherin	88,98	Rac1	0,4	E-cadherin	Rac1	999	5879	Gene	Gene	mutation|amod|START_ENTITY associated|nmod|mutation phenotype|acl|associated contribute|nmod|phenotype contribute|nsubj|END_ENTITY	Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation .
20368760	0	E-cadherin	20,30	Rac1	40,44	E-cadherin	Rac1	442858(Tax:9615)	403955(Tax:9615)	Gene	Gene	Response|compound|START_ENTITY Response|compound|END_ENTITY	Lateral Mobility of E-cadherin Enhances Rac1 Response in Epithelial Cells .
15133476	0	E-cadherin	43,53	S100A4	14,20	E-cadherin	S100A4	999	6275	Gene	Gene	expression|amod|START_ENTITY combined|nmod|expression END_ENTITY|acl|combined	Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant_melanoma .
16297707	0	E-cadherin	17,27	S100A4	0,6	E-cadherin	S100A4	999	6275	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	S100A4 regulates E-cadherin expression in oral_squamous_cell_carcinoma .
16685438	0	E-cadherin	73,83	S100A4	108,114	E-cadherin	S100A4	999	6275	Gene	Gene	decreased|dobj|START_ENTITY decreased|advcl|expression expression|compound|END_ENTITY	Poor outcome of patients with pulmonary_adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression .
16865243	0	E-cadherin	52,62	S100A4	10,16	E-cadherin	S100A4	999	6275	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic_cancer .
19043527	0	E-cadherin	116,126	S100A4	9,15	E-cadherin	S100A4	999	6275	Gene	Gene	Reduction|compound|START_ENTITY Paralleled|nmod|Reduction Expression|dep|Paralleled Expression|compound|END_ENTITY	Frequent S100A4 Expression with Unique Splicing Pattern in Gastric_Cancers : A Hypomethylation Event Paralleled with E-cadherin Reduction and Wnt Activation .
26897964	0	E-cadherin	42,52	S100A4	32,38	E-cadherin	S100A4	999	6275	Gene	Gene	Expression|compound|START_ENTITY Mediates|nmod|Expression Mediates|dobj|Regulation Regulation|nmod|END_ENTITY	EZH2 Mediates the Regulation of S100A4 on E-cadherin Expression and the Proliferation , Migration of Gastric_Cancer Cells .
11430829	0	E-cadherin	68,78	SIP1	49,53	E-cadherin	SIP1	999	9839	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion .
11912130	0	E-cadherin	39,49	SLUG	4,8	E-cadherin	SLUG	999	6591	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|protein protein|compound|END_ENTITY	The SLUG zinc-finger protein represses E-cadherin in breast_cancer .
16153441	0	E-cadherin	0,10	SLUG	57,61	E-cadherin	SLUG	999	6591	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|repressor repressor|acl|END_ENTITY	E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells .
14507651	0	E-cadherin	37,47	SNAIL	69,74	E-cadherin	SNAIL	999	6615	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian_carcinoma cells .
16203744	0	E-cadherin	0,10	SNAIL	48,53	E-cadherin	SNAIL	999	6615	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	E-cadherin and vitamin_D_receptor regulation by SNAIL and ZEB1 in colon_cancer : clinicopathological correlations .
16885349	0	E-cadherin	16,26	SPARC	0,5	E-cadherin	SPARC	999	6678	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	SPARC represses E-cadherin and induces mesenchymal transition during melanoma development .
22522110	0	E-cadherin	34,44	Salt-inducible_kinase_1	0,23	E-cadherin	Salt-inducible kinase 1	12550(Tax:10090)	17691(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Salt-inducible_kinase_1 regulates E-cadherin expression and intercellular junction stability .
21528083	0	E-cadherin	21,31	Shp2	9,13	E-cadherin	Shp2	999	5781	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
12508111	0	E-cadherin	40,50	Slug	25,29	E-cadherin	Slug	12550(Tax:10090)	20583(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions : a comparison with Snail and E47 repressors .
15709186	0	E-cadherin	23,33	Slug	0,4	E-cadherin	Slug	999	6591	Gene	Gene	tumors|amod|START_ENTITY Expression|nmod|tumors Expression|compound|END_ENTITY	Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal_squamous_cell_carcinoma .
16943193	0	E-cadherin	23,33	Slug	89,93	E-cadherin	Slug	999	6591	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug .
17018611	0	E-cadherin	49,59	Slug	106,110	E-cadherin	Slug	442858(Tax:9615)	486940(Tax:9615)	Gene	Gene	repressors|amod|START_ENTITY expressing|dobj|repressors cells|acl|expressing profiling|nmod|cells reveals|nsubj|profiling reveals|dobj|role role|nmod|END_ENTITY	Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail , Slug , and E47 factors in epithelial-mesenchymal transition .
18385519	0	E-cadherin	170,180	Slug	42,46	E-cadherin	Slug	999	6591	Gene	Gene	expression|amod|START_ENTITY affecting|dobj|expression reduces|advcl|affecting reduces|nsubj|END_ENTITY	Transforming_growth_factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression .
19536615	0	E-cadherin	29,39	Slug	59,63	E-cadherin	Slug	999	6591	Gene	Gene	repressors|amod|START_ENTITY repressors|appos|SIP1 SIP1|dep|END_ENTITY	Changes in the expression of E-cadherin repressors , Snail , Slug , SIP1 , and Twist , in the development and progression_of_ovarian_carcinoma : the important role of Snail in ovarian tumorigenesis and progression .
21656704	0	E-cadherin	15,25	Slug	0,4	E-cadherin	Slug	999	6591	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Slug regulates E-cadherin expression in metastatic adenocarcinoma cells isolated from pleural fluid .
22508482	0	E-cadherin	65,75	Slug	91,95	E-cadherin	Slug	999	6591	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Egr-1 mediates epidermal_growth_factor-induced downregulation of E-cadherin expression via Slug in human ovarian_cancer cells .
24910389	0	E-cadherin	15,25	Slug	0,4	E-cadherin	Slug	999	6591	Gene	Gene	repression|amod|START_ENTITY regulates|dobj|repression regulates|nsubj|END_ENTITY	Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis .
20890948	0	E-cadherin	0,10	Smad3	123,128	E-cadherin	Smad3	999	4088	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|advcl|inhibiting inhibiting|dobj|phosphorylation phosphorylation|amod|END_ENTITY	E-cadherin antagonizes transforming_growth_factor_b1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation .
22020340	0	E-cadherin	16,26	Smad3	0,5	E-cadherin	Smad3	999	4088	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Smad3 regulates E-cadherin via miRNA-200 pathway .
11323412	0	E-cadherin	8,18	Snail	104,109	E-cadherin	Snail	999	6615	Gene	Gene	expression|amod|START_ENTITY Loss|nmod|expression involves|nsubj|Loss involves|dobj|up-regulation up-regulation|nmod|END_ENTITY	Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail .
14673164	0	E-cadherin	15,25	Snail	0,5	E-cadherin	Snail	999	6615	Gene	Gene	repression|amod|START_ENTITY mediates|dobj|repression mediates|nsubj|END_ENTITY	Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone _ deacetylase_1 -LRB- HDAC1 -RRB- / HDAC2 complex .
16328348	0	E-cadherin	49,59	Snail	39,44	E-cadherin	Snail	999	6615	Gene	Gene	repressor|amod|START_ENTITY localization|appos|repressor localization|nmod|END_ENTITY	Expression and nuclear localization of Snail , an E-cadherin repressor , in adenocarcinomas of the upper gastrointestinal tract .
17587810	0	E-cadherin	36,46	Snail	73,78	E-cadherin	Snail	999	6615	Gene	Gene	transcriptional|amod|START_ENTITY signals|nmod|transcriptional repressor|nsubj|signals repressor|dobj|END_ENTITY	Nuclear localization signals of the E-cadherin transcriptional repressor Snail .
18550773	0	E-cadherin	60,70	Snail	19,24	E-cadherin	Snail	999	6615	Gene	Gene	down-regulation|nmod|START_ENTITY regulates|nmod|down-regulation regulates|dobj|END_ENTITY	Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian_cancer cells through estrogen_receptor_alpha .
18691339	0	E-cadherin	19,29	Snail	55,60	E-cadherin	Snail	999	6615	Gene	Gene	repress|dobj|START_ENTITY repress|nmod|induction induction|nmod|END_ENTITY	Bile_acids repress E-cadherin through the induction of Snail and increase cancer_invasiveness in human hepatobiliary_carcinoma .
19536615	0	E-cadherin	29,39	Snail	161,166	E-cadherin	Snail	999	6615	Gene	Gene	repressors|amod|START_ENTITY expression|nmod|repressors Changes|nmod|expression Changes|dep|role role|nmod|END_ENTITY	Changes in the expression of E-cadherin repressors , Snail , Slug , SIP1 , and Twist , in the development and progression_of_ovarian_carcinoma : the important role of Snail in ovarian tumorigenesis and progression .
19536615	0	E-cadherin	29,39	Snail	52,57	E-cadherin	Snail	999	6615	Gene	Gene	repressors|amod|START_ENTITY repressors|appos|SIP1 SIP1|compound|END_ENTITY	Changes in the expression of E-cadherin repressors , Snail , Slug , SIP1 , and Twist , in the development and progression_of_ovarian_carcinoma : the important role of Snail in ovarian tumorigenesis and progression .
21808237	0	E-cadherin	54,64	Snail	14,19	E-cadherin	Snail	999	6615	Gene	Gene	repressor|amod|START_ENTITY Expression|dep|repressor Expression|nmod|END_ENTITY	Expression of Snail and Slug in renal_cell_carcinoma : E-cadherin repressor Snail is associated with cancer_invasion and prognosis .
21808237	0	E-cadherin	54,64	Snail	75,80	E-cadherin	Snail	999	6615	Gene	Gene	repressor|amod|START_ENTITY repressor|acl:relcl|associated associated|nsubjpass|END_ENTITY	Expression of Snail and Slug in renal_cell_carcinoma : E-cadherin repressor Snail is associated with cancer_invasion and prognosis .
22820858	0	E-cadherin	18,28	Snail	40,45	E-cadherin	Snail	999	6615	Gene	Gene	Expression|nmod|START_ENTITY repressors|nsubj|Expression repressors|dobj|END_ENTITY	Expression of the E-cadherin repressors Snail , Slug and Zeb1 in urothelial_carcinoma of the urinary_bladder : relation to stromal fibroblast activation and invasive behaviour of carcinoma cells .
23254865	0	E-cadherin	63,73	Snail	28,33	E-cadherin	Snail	999	6615	Gene	Gene	changes|nmod|START_ENTITY role|nmod|changes role|nmod|END_ENTITY	Possible regulatory role of Snail in NF-kB-mediated changes in E-cadherin in gastric_cancer .
23261431	0	E-cadherin	59,69	Snail	25,30	E-cadherin	Snail	999	6615	Gene	Gene	degradation|nmod|START_ENTITY enhanced|dobj|degradation enhanced|nsubj|END_ENTITY	The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein_2 in oral_squamous_cell_carcinoma cells .
23807483	0	E-cadherin	94,104	Snail	78,83	E-cadherin	Snail	999	6615	Gene	Gene	repressors|amod|START_ENTITY family|nmod|repressors family|amod|END_ENTITY	Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small_cell_lung_cancer .
23856093	0	E-cadherin	15,25	Snail	68,73	E-cadherin	Snail	999	6615	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nmod|transactivation transactivation|nmod|END_ENTITY	VAV1 represses E-cadherin expression through the transactivation of Snail and Slug : a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial_ovarian_cancer .
18519590	0	E-cadherin	35,45	Snail1	64,70	E-cadherin	Snail1	999	6615	Gene	Gene	repression|amod|START_ENTITY required|nmod|repression required|nmod|factor factor|amod|END_ENTITY	Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor .
20801642	0	E-cadherin	79,89	Snail1	115,121	E-cadherin	Snail1	999	6615	Gene	Gene	transcription|nmod|START_ENTITY regulates|dobj|transcription regulates|nmod|interaction interaction|nmod|END_ENTITY	Four and a half LIM protein 2 -LRB- FHL2 -RRB- negatively regulates the transcription of E-cadherin through interaction with Snail1 .
22158034	0	E-cadherin	34,44	Snail1	20,26	E-cadherin	Snail1	999	6615	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Akt2 interacts with Snail1 in the E-cadherin promoter .
24297167	0	E-cadherin	55,65	Snail1	21,27	E-cadherin	Snail1	999	6615	Gene	Gene	repression|amod|START_ENTITY zinc|nmod|repression zinc|nsubj|role role|nmod|END_ENTITY	Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition .
17301079	0	E-cadherin	42,52	TGF-beta	64,72	E-cadherin	TGF-beta	999	7040	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic_cancer cell line PANC-1 .
17452626	0	E-cadherin	18,28	TGFbeta3	0,8	E-cadherin	TGFbeta3	12550(Tax:10090)	21809(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex .
25446087	0	E-cadherin	67,77	TLE1	0,4	E-cadherin	TLE1	999	7088	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	TLE1 promotes EMT in A549 lung_cancer cells through suppression of E-cadherin .
19809566	0	E-cadherin	24,34	TNF-alpha	0,9	E-cadherin	TNF-alpha	999	7124	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	TNF-alpha downregulates E-cadherin and sensitizes response to y-irradiation in Caco-2 cells .
17258791	0	E-cadherin	58,68	TWIST	16,21	E-cadherin	TWIST	999	7291	Gene	Gene	Significance|nmod|START_ENTITY Significance|nmod|expression expression|amod|END_ENTITY	Significance of TWIST expression and its association with E-cadherin in bladder_cancer .
18829543	0	E-cadherin	15,25	Tbx3	0,4	E-cadherin	Tbx3	999	6926	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Tbx3 represses E-cadherin expression and enhances melanoma_invasiveness .
25869072	0	E-cadherin	91,101	Transforming_growth_factor-a	0,28	E-cadherin	Transforming growth factor-a	999	7124	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-a induces human ovarian_cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner .
20025748	0	E-cadherin	58,68	Twist	16,21	E-cadherin	Twist	999	7291	Gene	Gene	Significance|nmod|START_ENTITY Significance|nmod|expression expression|compound|END_ENTITY	Significance of Twist expression and its association with E-cadherin in esophageal_squamous_cell_carcinoma .
23856093	0	E-cadherin	15,25	VAV1	0,4	E-cadherin	VAV1	999	7409	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	VAV1 represses E-cadherin expression through the transactivation of Snail and Slug : a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial_ovarian_cancer .
16585181	0	E-cadherin	14,24	VHL	39,42	E-cadherin	VHL	999	7428	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of E-cadherin expression by VHL and hypoxia-inducible factor .
17060462	0	E-cadherin	30,40	VHL	0,3	E-cadherin	VHL	999	7428	Gene	Gene	transcription|amod|START_ENTITY promotes|dobj|transcription promotes|nsubj|END_ENTITY	VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail .
17245122	0	E-cadherin	37,47	VHL	12,15	E-cadherin	VHL	999	7428	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of VHL in the regulation of E-cadherin : a new connection in an old pathway .
25373475	0	E-cadherin	17,27	Vangl2	0,6	E-cadherin	Vangl2	12550(Tax:10090)	93840(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Vangl2 regulates E-cadherin in epithelial cells .
20086044	0	E-cadherin	32,42	Vinculin	0,8	E-cadherin	Vinculin	999	7414	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin .
20584916	0	E-cadherin	21,31	Vinculin	0,8	E-cadherin	Vinculin	999	7414	Gene	Gene	mechanosensing|amod|START_ENTITY potentiates|dobj|mechanosensing potentiates|nsubj|END_ENTITY	Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner .
9405455	0	E-cadherin	32,42	Vinculin	0,8	E-cadherin	Vinculin	999	7414	Gene	Gene	complex|amod|START_ENTITY associated|nmod|complex associated|nsubjpass|END_ENTITY	Vinculin is associated with the E-cadherin adhesion complex .
12937339	0	E-cadherin	14,24	WNT7a	0,5	E-cadherin	WNT7a	999	7476	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	WNT7a induces E-cadherin in lung_cancer cells .
10753894	0	E-cadherin	0,10	WT1	16,19	E-cadherin	WT1	12550(Tax:10090)	22431(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	E-cadherin is a WT1 target gene .
16707460	0	E-cadherin	41,51	ZEB1	107,111	E-cadherin	ZEB1	999	6935	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|prostaglandin_E prostaglandin_E|acl:relcl|induces induces|dobj|END_ENTITY	Cyclooxygenase-2-dependent regulation of E-cadherin : prostaglandin_E -LRB- 2 -RRB- induces transcriptional repressors ZEB1 and snail in non-small_cell_lung_cancer .
20418909	0	E-cadherin	15,25	ZEB1	0,4	E-cadherin	ZEB1	999	6935	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1 .
20625840	0	E-cadherin	97,107	ZEB1	76,80	E-cadherin	ZEB1	999	6935	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression .
22147512	0	E-cadherin	104,114	ZEB1	85,89	E-cadherin	ZEB1	999	6935	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|Recruitment Recruitment|nmod|END_ENTITY	Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic_cancer .
22205962	0	E-cadherin	0,10	ZEB1	61,65	E-cadherin	ZEB1	999	6935	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|suppression suppression|nmod|repressor repressor|compound|END_ENTITY	E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing .
23743934	0	E-cadherin	36,46	ZEB1	0,4	E-cadherin	ZEB1	999	6935	Gene	Gene	downregulation|amod|START_ENTITY associated|nmod|downregulation overexpression|acl|associated overexpression|nummod|END_ENTITY	ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial_carcinoma .
23667256	0	E-cadherin	15,25	Zeb1	0,4	E-cadherin	Zeb1	114424(Tax:7955)	114425(Tax:7955)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Zeb1 regulates E-cadherin and Epcam -LRB- epithelial_cell_adhesion_molecule -RRB- expression to control cell behavior in early zebrafish development .
26097576	0	E-cadherin	75,85	Zinc-finger_protein_X-linked	19,47	E-cadherin	Zinc-finger protein X-linked	999	7543	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|nmod|END_ENTITY	High expression of Zinc-finger_protein_X-linked is associated with reduced E-cadherin expression and unfavorable prognosis in nasopharyngeal_carcinoma .
10673383	0	E-cadherin	26,36	alpha-catenin	72,85	E-cadherin	alpha-catenin	999	1495	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin .
18794357	0	E-cadherin	42,52	androgen_receptor	10,27	E-cadherin	androgen receptor	12550(Tax:10090)	11835(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Activated androgen_receptor downregulates E-cadherin gene expression and promotes tumor metastasis .
10664629	0	E-cadherin	28,38	autocrine_motility_factor_receptor	72,106	E-cadherin	autocrine motility factor receptor	999	267	Gene	Gene	expression|amod|START_ENTITY Correlation|nmod|expression Correlation|nmod|END_ENTITY	Correlation between loss of E-cadherin expression and overexpression of autocrine_motility_factor_receptor in association with progression of human gastric_cancers .
24268141	0	E-cadherin	64,74	b-Catenin	0,9	E-cadherin	b-Catenin	999	1499	Gene	Gene	strengths|amod|START_ENTITY clutch|nmod|strengths serves|nmod|clutch serves|nsubj|END_ENTITY	b-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths .
21884207	0	E-cadherin	61,71	b-catenin	25,34	E-cadherin	b-catenin	999	1499	Gene	Gene	loss|nmod|START_ENTITY synchronized|nmod|loss synchronized|nsubj|translocation translocation|nmod|END_ENTITY	Nuclear translocation of b-catenin synchronized with loss of E-cadherin in oral_epithelial_dysplasia with a characteristic two-phase appearance .
22098108	0	E-cadherin	58,68	b-catenin	102,111	E-cadherin	b-catenin	999	1499	Gene	Gene	expression|amod|START_ENTITY modulation|nmod|expression modulation|nmod|signaling signaling|amod|END_ENTITY	Inhibition of IGF-1 signaling by genistein : modulation of E-cadherin expression and downregulation of b-catenin signaling in hormone refractory PC-3 prostate_cancer cells .
22209340	0	E-cadherin	53,63	b-catenin	42,51	E-cadherin	b-catenin	999	1499	Gene	Gene	chain|amod|START_ENTITY chain|amod|END_ENTITY	Immunohistochemical expression profile of b-catenin , E-cadherin , P-cadherin , laminin-5y2 chain , and SMAD4 in colorectal_serrated_adenocarcinoma .
23355201	0	E-cadherin	17,27	b-catenin	41,50	E-cadherin	b-catenin	999	1499	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Combined loss of E-cadherin and aberrant b-catenin protein expression correlates with a poor prognosis for small intestinal_adenocarcinomas .
25039920	0	E-cadherin	71,81	b-catenin	91,100	E-cadherin	b-catenin	999	1499	Gene	Gene	Secretory_Leukocyte_Protease_Inhibitor|dep|START_ENTITY induces|nsubj|Secretory_Leukocyte_Protease_Inhibitor induces|dobj|re-localisation re-localisation|amod|END_ENTITY	Secretory_Leukocyte_Protease_Inhibitor -LRB- SLPI -RRB- expression downregulates E-cadherin , induces b-catenin re-localisation and triggers apoptosis-related events in breast_cancer cells .
26081960	0	E-cadherin	19,29	b-catenin	41,50	E-cadherin	b-catenin	999	1499	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The expression of E-cadherin , vimentin , b-catenin , transforming_growth_factor-b1 in oral_squamous_cell_carcinomas -RSB- .
26316041	0	E-cadherin	0,10	b-catenin	31,40	E-cadherin	b-catenin	999	1499	Gene	Gene	knockdown|amod|START_ENTITY increases|nsubj|knockdown increases|dobj|END_ENTITY	E-cadherin knockdown increases b-catenin reducing colorectal_cancer chemosensitivity only in three-dimensional cultures .
10085258	0	E-cadherin	0,10	beta-catenin	28,40	E-cadherin	beta-catenin	999	1499	Gene	Gene	binding|compound|START_ENTITY prevents|nsubj|binding prevents|dobj|localization localization|amod|END_ENTITY	E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF -1 - mediated transactivation .
10571513	0	E-cadherin	96,106	beta-catenin	35,47	E-cadherin	beta-catenin	999	1499	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of E-cadherin , alpha - _ beta-catenin , and CD44V6 and the subcellular localization of E-cadherin and CD44V6 in normal epidermis and basal_cell_carcinoma .
10583557	0	E-cadherin	32,42	beta-catenin	54,66	E-cadherin	beta-catenin	999	1499	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Ultrastructural localization of E-cadherin and alpha - / beta-catenin in adenoid_cystic_carcinoma .
10604738	0	E-cadherin	77,87	beta-catenin	38,50	E-cadherin	beta-catenin	999	1499	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric_cancer .
10652321	0	E-cadherin	49,59	beta-catenin	18,30	E-cadherin	beta-catenin	999	1499	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Truncation of the beta-catenin binding domain of E-cadherin precedes epithelial apoptosis during prostate and mammary involution .
10830618	0	E-cadherin	22,32	beta-catenin	44,56	E-cadherin	beta-catenin	999	1499	Gene	Gene	influences|nsubj|START_ENTITY influences|dobj|localization localization|amod|END_ENTITY	Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate .
10864814	0	E-cadherin	146,156	beta-catenin	14,26	E-cadherin	beta-catenin	999	1499	Gene	Gene	expression|amod|START_ENTITY correlation|nmod|expression vitro|dep|correlation undergoing|advcl|vitro cytotrophoblasts|xcomp|undergoing cytotrophoblasts|nsubj|Regulation Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation of beta-catenin mRNA and protein levels in human villous cytotrophoblasts undergoing aggregation and fusion in vitro : correlation with E-cadherin expression .
11024053	0	E-cadherin	58,68	beta-catenin	116,128	E-cadherin	beta-catenin	12550(Tax:10090)	12387(Tax:10090)	Gene	Gene	bisecting|nmod|START_ENTITY addition|acl|bisecting down-regulates|nsubj|addition down-regulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin .
11179484	0	E-cadherin	10,20	beta-catenin	30,42	E-cadherin	beta-catenin	999	1499	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|localization localization|amod|END_ENTITY	Decreased E-cadherin augments beta-catenin nuclear localization : studies in breast_cancer cell lines .
11205306	0	E-cadherin	20,30	beta-catenin	32,44	E-cadherin	beta-catenin	12550(Tax:10090)	12387(Tax:10090)	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of E-cadherin , beta-catenin , P120ctn in patients with transitional cell bladder_cancer .
11211307	0	E-cadherin	63,73	beta-catenin	24,36	E-cadherin	beta-catenin	999	1499	Gene	Gene	distribution|amod|START_ENTITY distribution|nmod|END_ENTITY	Altered distribution of beta-catenin , and its binding proteins E-cadherin and APC , in ulcerative_colitis-related colorectal_cancers .
11381089	0	E-cadherin	0,10	beta-catenin	60,72	E-cadherin	beta-catenin	999	1499	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner .
11564756	0	E-cadherin	0,10	beta-catenin	71,83	E-cadherin	beta-catenin	999	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY	E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity .
11710913	0	E-cadherin	114,124	beta-catenin	47,59	E-cadherin	beta-catenin	999	1499	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of human keratinocyte beta-catenin and plakoglobin reversibly regulates their binding to E-cadherin and alpha-catenin .
12507936	0	E-cadherin	99,109	beta-catenin	66,78	E-cadherin	beta-catenin	12550(Tax:10090)	12387(Tax:10090)	Gene	Gene	mediate|nmod|START_ENTITY mediate|dobj|dissociation dissociation|nmod|END_ENTITY	Matrix metalloproteinase -LRB- s -RRB- mediate -LRB- s -RRB- NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF -1 complex .
12786894	0	E-cadherin	0,10	beta-catenin	28,40	E-cadherin	beta-catenin	999	1499	Gene	Gene	loss|amod|START_ENTITY loss|nmod|alterations alterations|amod|END_ENTITY	E-cadherin loss rather than beta-catenin alterations is a common feature of poorly differentiated thyroid_carcinomas .
12839684	0	E-cadherin	14,24	beta-catenin	62,74	E-cadherin	beta-catenin	999	1499	Gene	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	-LSB- Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal_carcinoma cells -RSB- .
14623871	0	E-cadherin	18,28	beta-catenin	88,100	E-cadherin	beta-catenin	999	1499	Gene	Gene	expression|amod|START_ENTITY Autoregulation|nmod|expression Autoregulation|dep|roles roles|nmod|signaling signaling|amod|END_ENTITY	Autoregulation of E-cadherin expression by cadherin-cadherin interactions : the roles of beta-catenin signaling , Slug , and MAPK .
15328184	0	E-cadherin	68,78	beta-catenin	112,124	E-cadherin	beta-catenin	999	1499	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Invasion and metastasis of oral_cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin .
15943787	0	E-cadherin	79,89	beta-catenin	28,40	E-cadherin	beta-catenin	999	1499	Gene	Gene	expression|nmod|START_ENTITY correlates|nmod|expression correlates|amod|END_ENTITY	Accumulation of cytoplasmic beta-catenin correlates with reduced expression of E-cadherin , but not with phosphorylated Akt in esophageal_squamous_cell_carcinoma : immunohistochemical study .
16132582	0	E-cadherin	28,38	beta-catenin	108,120	E-cadherin	beta-catenin	999	1499	Gene	Gene	loss|nmod|START_ENTITY loss|dep|cross-talk cross-talk|nmod|Wnt Wnt|acl|determining determining|dobj|fate fate|nmod|END_ENTITY	Frequent loss of membranous E-cadherin in gastric_cancers : A cross-talk with Wnt in determining the fate of beta-catenin .
16204054	0	E-cadherin	0,10	beta-catenin	45,57	E-cadherin	beta-catenin	999	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|association association|nmod|END_ENTITY	E-cadherin regulates the association between beta-catenin and actinin-4 .
16224588	0	E-cadherin	14,24	beta-catenin	26,38	E-cadherin	beta-catenin	999	1499	Gene	Gene	molecules|amod|START_ENTITY molecules|amod|END_ENTITY	Expression of E-cadherin , beta-catenin , and CD-44v6 cell adhesion molecules in primary tumors and metastases of colorectal_adenocarcinoma .
16399195	0	E-cadherin	10,20	beta-catenin	29,41	E-cadherin	beta-catenin	999	1499	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head_and_neck_squamous_carcinomas .
16425303	0	E-cadherin	20,30	beta-catenin	32,44	E-cadherin	beta-catenin	999	1499	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of E-cadherin , beta-catenin , MMPs -LRB- 7 and 9 -RRB- , and TIMPs -LRB- 1 and 2 -RRB- in patients with colorectal_carcinoma .
16966438	0	E-cadherin	36,46	beta-catenin	22,34	E-cadherin	beta-catenin	999	1499	Gene	Gene	cycloxygenase-2|amod|START_ENTITY cycloxygenase-2|amod|END_ENTITY	Altered expression of beta-catenin , E-cadherin , cycloxygenase-2 , and p53 protein by ovine intestinal adenocarcinoma cells .
17535680	0	E-cadherin	48,58	beta-catenin	60,72	E-cadherin	beta-catenin	999	1499	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Unusual expression and molecular mechanisms of E-cadherin , beta-catenin in correlation with clinicopathologic parameters in neuroblastoma -RSB- .
17908479	0	E-cadherin	14,24	beta-catenin	26,38	E-cadherin	beta-catenin	999	1499	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|cathepsin_D cathepsin_D|amod|END_ENTITY	Expression of E-cadherin , beta-catenin , cathepsin_D , gelatinases and their inhibitors in invasive_ductal_breast_carcinomas .
17959228	0	E-cadherin	8,18	beta-catenin	57,69	E-cadherin	beta-catenin	999	1499	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas .
18083766	0	E-cadherin	12,22	beta-catenin	145,157	E-cadherin	beta-catenin	442858(Tax:9615)	477032(Tax:9615)	Gene	Gene	adhesion|compound|START_ENTITY rescued|nsubjpass|adhesion rescued|nmod|mutations mutations|nmod|END_ENTITY	Compromised E-cadherin adhesion and epithelial barrier function with activation of G protein-coupled receptors is rescued by Y-to-F mutations in beta-catenin .
18553167	0	E-cadherin	0,10	beta-catenin	47,59	E-cadherin	beta-catenin	999	1499	Gene	Gene	fucosylation|amod|START_ENTITY regulates|nsubj|fucosylation regulates|dobj|accumulation accumulation|amod|END_ENTITY	E-cadherin core fucosylation regulates nuclear beta-catenin accumulation in lung_cancer cells .
18565826	0	E-cadherin	0,10	beta-catenin	20,32	E-cadherin	beta-catenin	999	1499	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|activity activity|amod|END_ENTITY	E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression .
18593713	0	E-cadherin	41,51	beta-catenin	17,29	E-cadherin	beta-catenin	999	1499	Gene	Gene	complex|amod|START_ENTITY stabilizes|nmod|complex stabilizes|dobj|END_ENTITY	Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion .
18655368	0	E-cadherin	34,44	beta-catenin	20,32	E-cadherin	beta-catenin	999	1499	Gene	Gene	complex|amod|START_ENTITY Immunoexpression|dep|complex Immunoexpression|nmod|END_ENTITY	Immunoexpression of beta-catenin -- E-cadherin complex in primary_serous_ovarian_tumors .
18674869	0	E-cadherin	0,10	beta-catenin	12,24	E-cadherin	beta-catenin	999	1499	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	E-cadherin , beta-catenin adhesion complex and relation to matrilysin expression in pT3 rectosigmoid_cancers .
20086044	0	E-cadherin	32,42	beta-catenin	68,80	E-cadherin	beta-catenin	999	1499	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|binding binding|nmod|END_ENTITY	Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin .
21299609	0	E-cadherin	24,34	beta-catenin	43,55	E-cadherin	beta-catenin	999	1499	Gene	Gene	localization|nmod|START_ENTITY localization|amod|END_ENTITY	Nuclear localization of E-cadherin but not beta-catenin in human ovarian_granulosa_cell_tumours and normal ovarian follicles and ovarian_stroma .
7629993	0	E-cadherin	16,26	beta-catenin	46,58	E-cadherin	beta-catenin	999	1499	Gene	Gene	line|compound|START_ENTITY line|amod|due due|nmod|mutation mutation|nmod|END_ENTITY	-LSB- Dysfunction of E-cadherin due to mutation of beta-catenin in a scirrhous gastric_cancer cell line -RSB- .
7806582	0	E-cadherin	0,10	beta-catenin	52,64	E-cadherin	beta-catenin	999	1499	Gene	Gene	compete|nsubj|START_ENTITY compete|nmod|interaction interaction|nmod|END_ENTITY	E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton .
7954478	0	E-cadherin	58,68	beta-catenin	12,24	E-cadherin	beta-catenin	999	1499	Gene	Gene	interaction|nmod|START_ENTITY disrupts|dobj|interaction disrupts|nsubj|END_ENTITY	A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin : a cause of loss of intercellular adhesiveness in human cancer cell lines .
9759521	0	E-cadherin	62,72	beta-catenin	101,113	E-cadherin	beta-catenin	12550(Tax:10090)	12387(Tax:10090)	Gene	Gene	complexes|amod|START_ENTITY complexes|acl|containing containing|ccomp|contribute contribute|nsubj|END_ENTITY	Cadherin/catenin complexes in murine epidermal keratinocytes : E-cadherin complexes containing either beta-catenin or plakoglobin contribute to stable cell-cell contacts .
19661296	0	E-cadherin	14,24	beta-catenin_and_APC	26,46	E-cadherin	beta-catenin and APC	999	1499;324	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Expression of E-cadherin , beta-catenin_and_APC protein in canine colorectal_tumours .
17908479	0	E-cadherin	14,24	cathepsin_D	40,51	E-cadherin	cathepsin D	999	1509	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Expression of E-cadherin , beta-catenin , cathepsin_D , gelatinases and their inhibitors in invasive_ductal_breast_carcinomas .
18242386	0	E-cadherin	74,84	cyclooxygenase-2	22,38	E-cadherin	cyclooxygenase-2	999	5743	Gene	Gene	upregulation|nmod|START_ENTITY induces|dobj|upregulation induces|nsubj|Etodolac Etodolac|appos|inhibitor inhibitor|amod|END_ENTITY	Etodolac , a selective cyclooxygenase-2 inhibitor , induces upregulation of E-cadherin and has antitumor effect on human bladder_cancer cells in vitro and in vivo .
19622294	0	E-cadherin	92,102	cyclooxygenase-2	61,77	E-cadherin	cyclooxygenase-2	999	5743	Gene	Gene	expression|amod|START_ENTITY celecoxib|nmod|expression celecoxib|appos|inhibitor inhibitor|amod|END_ENTITY	-LSB- Short-term preoperative treatment of celecoxib , a selective cyclooxygenase-2 inhibitor , on E-cadherin expression in gastric_carcinoma tissues -RSB- .
18677652	0	E-cadherin	106,116	dysadherin	27,37	E-cadherin	dysadherin	999	53827	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|nmod|END_ENTITY	Differential expression of dysadherin in papillary_thyroid_carcinoma and microcarcinoma : correlation with E-cadherin .
7826368	0	E-cadherin	9,19	epidermal_growth_factor_receptor	34,66	E-cadherin	epidermal growth factor receptor	999	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Enhanced E-cadherin expression in epidermal_growth_factor_receptor expressing cells .
9535896	0	E-cadherin	66,76	epidermal_growth_factor_receptor	4,36	E-cadherin	epidermal growth factor receptor	999	1956	Gene	Gene	interaction|nmod|START_ENTITY modulates|dobj|interaction modulates|nsubj|END_ENTITY	The epidermal_growth_factor_receptor modulates the interaction of E-cadherin with the actin cytoskeleton .
22185284	0	E-cadherin	55,65	hDlg	34,38	E-cadherin	hDlg	999	1739	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring .
10854534	0	E-cadherin	66,76	hepatoma_cell_lines_G-1_and_G-5	90,121	E-cadherin	hepatoma cell lines G-1 and G-5	12550(Tax:10090)	81845(Tax:10090)	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation between metastatic potency and the down-regulation of E-cadherin in the mouse hepatoma_cell_lines_G-1_and_G-5 .
26819089	0	E-cadherin	25,35	histone_demethylase_UTX	54,77	E-cadherin	histone demethylase UTX	999	7403	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Epigenetic regulation of E-cadherin expression by the histone_demethylase_UTX in colon_cancer cells .
15053919	0	E-cadherin	14,24	integrin-linked_kinase	89,111	E-cadherin	integrin-linked kinase	999	3611	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression transcriptional|nsubj|Regulation transcriptional|nmod|END_ENTITY	Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked_kinase .
20091050	0	E-cadherin	87,97	integrin-linked_kinase	20,42	E-cadherin	integrin-linked kinase	999	3611	Gene	Gene	snail|amod|START_ENTITY expression|nmod|snail expression|nmod|expression expression|nmod|correlates correlates|amod|END_ENTITY	Tumor expression of integrin-linked_kinase -LRB- ILK -RRB- correlates with the expression of the E-cadherin repressor snail : an immunohistochemical study in ductal pancreatic_adenocarcinoma .
21136077	0	E-cadherin	106,116	integrin-linked_kinase	14,36	E-cadherin	integrin-linked kinase	999	3611	Gene	Gene	expression|amod|START_ENTITY correlation|nmod|expression Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of integrin-linked_kinase in lung_squamous_cell_carcinoma and adenocarcinoma : correlation with E-cadherin expression , tumor microvessel density and clinical outcome .
17409452	0	E-cadherin	35,45	leptin	15,21	E-cadherin	leptin	999	3952	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Evidences that leptin up-regulates E-cadherin expression in breast_cancer : effects on tumor growth and progression .
22340517	0	E-cadherin	19,29	matrix_metalloproteinase-2	43,69	E-cadherin	matrix metalloproteinase-2	999	4313	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Hypoxia suppresses E-cadherin and enhances matrix_metalloproteinase-2 expression favoring esophageal_carcinoma migration and invasion via hypoxia_inducible_factor-1_alpha activation .
12759241	0	E-cadherin	49,59	matrix_metalloproteinase-7	12,38	E-cadherin	matrix metalloproteinase-7	12550(Tax:10090)	17393(Tax:10090)	Gene	Gene	ectodomain|amod|START_ENTITY mediates|dobj|ectodomain mediates|nsubj|Matrilysin Matrilysin|dep|END_ENTITY	Matrilysin -LRB- matrix_metalloproteinase-7 -RRB- mediates E-cadherin ectodomain shedding in injured lung epithelium .
16969501	0	E-cadherin	21,31	matrix_metalloproteinase-7	33,59	E-cadherin	matrix metalloproteinase-7	999	4316	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Relationship between E-cadherin , matrix_metalloproteinase-7 gene expression and clinicopathological features in gastric_carcinoma .
18303430	0	E-cadherin	184,194	matrix_metalloproteinase-9	126,152	E-cadherin	matrix metalloproteinase-9	999	4318	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Tumor response to combination celecoxib and erlotinib therapy in non-small_cell_lung_cancer is associated with a low baseline matrix_metalloproteinase-9 and a decline in serum-soluble E-cadherin .
23929433	0	E-cadherin	17,27	miR-23a	0,7	E-cadherin	miR-23a	999	407010	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal_cancer .
23423910	0	E-cadherin	95,105	p120_catenin	135,147	E-cadherin	p120 catenin	12550(Tax:10090)	12388(Tax:10090)	Gene	Gene	START_ENTITY|nmod|manner manner|nmod|END_ENTITY	Delta-catenin promotes the proliferation and invasion of colorectal_cancer cells by binding to E-cadherin in a competitive manner with p120_catenin .
24910389	0	E-cadherin	15,25	p19Arf	41,47	E-cadherin	p19Arf	999	1029	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis .
10385363	0	E-cadherin	108,118	p53	103,106	E-cadherin	p53	999	7157	Gene	Gene	epidermal_growth_factor_receptor|dep|START_ENTITY epidermal_growth_factor_receptor|compound|END_ENTITY	Evaluation of malignancy and the prognosis of esophageal_cancer based on an immunohistochemical study -LRB- p53 , E-cadherin , epidermal_growth_factor_receptor -RRB- .
11665847	0	E-cadherin	8,18	p53	79,82	E-cadherin	p53	999	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Loss of E-cadherin expression in gastric_intestinal_metaplasia and later stage p53 altered expression in gastric_carcinogenesis .
21493295	0	E-cadherin	59,69	p53	71,74	E-cadherin	p53	999	7157	Gene	Gene	p16|dep|START_ENTITY p16|dep|END_ENTITY	Loss of heterozygosity of tumor suppressor genes -LRB- p16 , Rb , E-cadherin , p53 -RRB- in hypopharynx_squamous_cell_carcinoma .
21528083	0	E-cadherin	21,31	p53	33,36	E-cadherin	p53	999	7157	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
9463572	0	E-cadherin	14,24	p53	49,52	E-cadherin	p53	999	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|status status|compound|END_ENTITY	Expression of E-cadherin and its relation to the p53 protein status in human breast_carcinomas .
17525203	0	E-cadherin	43,53	slug	69,73	E-cadherin	slug	999	6591	Gene	Gene	production|amod|START_ENTITY production|nmod|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells .
19389926	0	E-cadherin	91,101	slug	144,148	E-cadherin	slug	999	6591	Gene	Gene	expression|amod|START_ENTITY modulating|dobj|expression modulating|nmod|transactivation transactivation|nmod|END_ENTITY	Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis , modulating E-cadherin expression through the transactivation of slug .
25086032	0	E-cadherin	134,144	slug	97,101	E-cadherin	slug	999	6591	Gene	Gene	degradation|amod|START_ENTITY transcription|nmod|degradation END_ENTITY|dobj|transcription	Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation : dual role of scaffold/matrix _ attachment_region-binding_protein_1 -LRB- SMAR1 -RRB- in breast_cancer cells .
25086032	0	E-cadherin	54,64	slug	97,101	E-cadherin	slug	999	6591	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|repression repression|acl|END_ENTITY	Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation : dual role of scaffold/matrix _ attachment_region-binding_protein_1 -LRB- SMAR1 -RRB- in breast_cancer cells .
10655586	0	E-cadherin	89,99	snail	25,30	E-cadherin	snail	12550(Tax:10090)	20613(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY repressing|dobj|expression controls|advcl|repressing controls|nsubj|END_ENTITY	The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression .
10655587	0	E-cadherin	49,59	snail	25,30	E-cadherin	snail	999	6615	Gene	Gene	expression|amod|START_ENTITY repressor|nmod|expression repressor|nsubj|END_ENTITY	The transcription factor snail is a repressor of E-cadherin gene expression in epithelial_tumour cells .
11244511	0	E-cadherin	121,131	snail	143,148	E-cadherin	snail	999	6615	Gene	Gene	repressor|amod|START_ENTITY transcription|nmod|repressor suppresses|dobj|transcription suppresses|parataxis|END_ENTITY	Inhibition of integrin_linked_kinase -LRB- ILK -RRB- suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor , snail , in APC - / - human colon_carcinoma cells .
16849535	0	E-cadherin	51,61	snail	65,70	E-cadherin	snail	999	6615	Gene	Gene	repression|nmod|START_ENTITY interfere|nmod|repression interfere|nmod|END_ENTITY	SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug : a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial_sarcoma .
18321996	0	E-cadherin	70,80	snail	127,132	E-cadherin	snail	999	6615	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nmod|induction induction|nmod|END_ENTITY	Inhibition of CCN6 -LRB- Wnt-1-induced_signaling_protein_3 -RRB- down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1 .
22969242	0	E-cadherin	45,55	snail	80,85	E-cadherin	snail	999	6615	Gene	Gene	expression|amod|START_ENTITY reduce|dobj|expression reduce|advcl|enhancing enhancing|dobj|expression expression|compound|END_ENTITY	Prostaglandin_E -LRB- 2 -RRB- and interleukin-1b reduce E-cadherin expression by enhancing snail expression in gastric_cancer cells .
26081960	0	E-cadherin	19,29	transforming_growth_factor-b1	52,81	E-cadherin	transforming growth factor-b1	999	7040	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The expression of E-cadherin , vimentin , b-catenin , transforming_growth_factor-b1 in oral_squamous_cell_carcinomas -RSB- .
16367920	0	E-cadherin	23,33	transforming_growth_factor-beta1	71,103	E-cadherin	transforming growth factor-beta1	999	7040	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Aberrant expression of E-cadherin and beta-catenin in association with transforming_growth_factor-beta1 in urinary_bladder_lesions in humans after the Chernobyl accident .
10457348	0	E-cadherin	64,74	urokinase_plasminogen_activator	14,45	E-cadherin	urokinase plasminogen activator	999	5328	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of urokinase_plasminogen_activator -LRB- uPA -RRB- activity by E-cadherin and hormones in mammary epithelial cells .
1918074	0	E-cadherin	55,65	uvomorulin	43,53	E-cadherin	uvomorulin	999	999	Gene	Gene	Biosynthesis|appos|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of the cell adhesion molecule uvomorulin -LRB- E-cadherin -RRB- in Madin-Darby canine kidney epithelial cells .
8144691	0	E-cadherin	32,42	uvomorulin	44,54	E-cadherin	uvomorulin	12550(Tax:10090)	12550(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of recombinant E-cadherin -LRB- uvomorulin -RRB- expressed in insect cells .
448070	0	E-rosette_augmenting_factor	11,38	E-RAF	40,45	E-rosette augmenting factor	E-RAF	51327	51327	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of E-rosette_augmenting_factor -LRB- E-RAF -RRB- after stimulation of human leukocytes with mitogens or antigens .
12945874	0	E-selectin	71,81	C-reactive_protein	11,29	E-selectin	C-reactive protein	6401	1401	Gene	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of C-reactive_protein on the release of von_Willebrand factor , E-selectin , thrombomodulin and intercellular_adhesion_molecule-1 from human umbilical vein endothelial cells .
11123285	0	E-selectin	64,74	CD4	113,116	E-selectin	CD4	6401	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
14634085	0	E-selectin	46,56	CD4	65,68	E-selectin	CD4	6401	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	In vitro differentiation from naive to mature E-selectin binding CD4 T cells : acquisition of skin-homing properties occurs independently of cutaneous lymphocyte antigen expression .
19159577	0	E-selectin	29,39	CD40L	15,20	E-selectin	CD40L	6401	959	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression induced|nsubj|Inhibition Inhibition|nmod|END_ENTITY	-LSB- Inhibition of CD40L induced E-selectin expression in endothelial cells through extracellular signal-regulated kinase signaling pathway -RSB- .
17392823	0	E-selectin	46,56	CD43	25,29	E-selectin	CD43	20339(Tax:10090)	20737(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type_hypersensitivity reactions in vivo .
15994957	0	E-selectin	47,57	CD44	0,4	E-selectin	CD44	6401	960	Gene	Gene	activity|amod|START_ENTITY possesses|dobj|activity possesses|nsubj|END_ENTITY	CD44 on LS174T colon_carcinoma cells possesses E-selectin ligand activity .
25339657	0	E-selectin	70,80	CD44	0,4	E-selectin	CD44	6401	960	Gene	Gene	ligands|amod|START_ENTITY functional|dobj|ligands functional|nsubj|isoforms isoforms|nummod|END_ENTITY	CD44 variant isoforms expressed by breast_cancer cells are functional E-selectin ligands under flow conditions .
25359776	0	E-selectin	76,86	CD44	27,31	E-selectin	CD44	6401	960	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Organization Organization|compound|END_ENTITY	Cytoskeletal Regulation of CD44 Membrane Organization and Interactions with E-selectin .
26124272	0	E-selectin	33,43	CD44	68,72	E-selectin	CD44	6401	960	Gene	Gene	Interaction|compound|START_ENTITY Interaction|nmod|END_ENTITY	Quantitative Characterization of E-selectin Interaction with Native CD44 and P-selectin_Glycoprotein_Ligand-1 -LRB- PSGL-1 -RRB- Using a Real Time Immunoprecipitation-based Binding Assay .
11123285	0	E-selectin	64,74	CD62E	76,81	E-selectin	CD62E	6401	6401	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
18472945	0	E-selectin	48,58	CD62E	60,65	E-selectin	CD62E	6401	6401	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Serum Concentration and Chemotactic Activity of E-selectin -LRB- CD62E -RRB- in Inflammatory_Bowel_Disease .
9218615	0	E-selectin	66,76	CD62E	78,83	E-selectin	CD62E	6401	6401	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin -LRB- CD62E -RRB- does not promote their activation .
16269612	0	E-selectin	21,31	CLA	35,38	E-selectin	CLA	6401	6404	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	CD43 is a ligand for E-selectin on CLA + human T cells .
7516056	0	E-selectin	24,34	ELAM-1	36,42	E-selectin	ELAM-1	6401	6401	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of soluble E-selectin -LRB- ELAM-1 -RRB- in immune-mediated neuropathies .
16980970	0	E-selectin	14,24	G-CSF	0,5	E-selectin	G-CSF	6401	1440	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	G-CSF induces E-selectin ligand expression on human myeloid cells .
10754335	0	E-selectin	24,34	ICAM-1	72,78	E-selectin	ICAM-1	6401	3383	Gene	Gene	tethering|nmod|START_ENTITY activates|nsubj|tethering activates|nmod|pathway pathway|amod|END_ENTITY	Neutrophil tethering on E-selectin activates beta_2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway .
12911509	0	E-selectin	8,18	ICAM-1	31,37	E-selectin	ICAM-1	6401	3383	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Soluble E-selectin and soluble ICAM-1 levels as markers of the activity of atopic_dermatitis in children .
14603993	0	E-selectin	28,38	ICAM-1	12,18	E-selectin	ICAM-1	6401	3383	Gene	Gene	P-selectin|appos|START_ENTITY P-selectin|compound|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFalphaRII in patients with coronary_artery_disease .
15495786	0	E-selectin	28,38	ICAM-1	12,18	E-selectin	ICAM-1	6401	3383	Gene	Gene	P-selectin|appos|START_ENTITY P-selectin|compound|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFRII in patients with coronary_artery_disease .
16459323	0	E-selectin	75,85	ICAM-1	51,57	E-selectin	ICAM-1	20339(Tax:10090)	15894(Tax:10090)	Gene	Gene	engagement|nmod|START_ENTITY rolling|nmod|engagement rolling|nmod|END_ENTITY	Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin .
19184433	0	E-selectin	76,86	ICAM-1	60,66	E-selectin	ICAM-1	6401	3383	Gene	Gene	role|nmod|START_ENTITY signaling|nsubj|role mediated|parataxis|signaling mediated|nmod|END_ENTITY	Kinetics of LFA-1 mediated adhesion of human neutrophils to ICAM-1 -- role of E-selectin signaling post-activation .
25138157	0	E-selectin	110,120	ICAM-1	21,27	E-selectin	ICAM-1	6401	3383	Gene	Gene	CD44|nmod|START_ENTITY engagement|nmod|CD44 upregulates|nmod|engagement upregulates|dobj|expression expression|compound|END_ENTITY	Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCa-p38-SP-1 pathway .
7473588	0	E-selectin	14,24	ICAM-1	27,33	E-selectin	ICAM-1	6401	3383	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Inhibition of E-selectin - , ICAM-1 - , and VCAM-1-mediated cell adhesion by benzo -LSB- b -RSB- thiophene - , benzofuran - , indole - , and naphthalene-2-carboxamides : identification of PD_144795 as an antiinflammatory agent .
7570951	0	E-selectin	20,30	ICAM-1	12,18	E-selectin	ICAM-1	6401	3383	Gene	Gene	class|nsubj|START_ENTITY class|advcl|Circulating Circulating|dobj|END_ENTITY	Circulating ICAM-1 , E-selectin , IL-2_receptor , and HLA class I in human small bowel , liver , and small bowel-plus-liver transplant recipients .
7686390	0	E-selectin	56,66	ICAM-1	47,53	E-selectin	ICAM-1	6401	3383	Gene	Gene	adhesion|amod|START_ENTITY adhesion|dep|END_ENTITY	Circulating intercellular adhesion molecule-1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in human malignancies .
9133922	0	E-selectin	78,88	ICAM-1	54,60	E-selectin	ICAM-1	6401	3383	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|compound|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
9434632	0	E-selectin	8,18	ICAM-1	63,69	E-selectin	ICAM-1	6401	3383	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|appos|END_ENTITY	Soluble E-selectin enhances intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human tumor cell lines .
9888481	0	E-selectin	56,66	ICAM-1	47,53	E-selectin	ICAM-1	6401	3383	Gene	Gene	intercellular_adhesion_molecule_1|amod|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Circulating intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in head_and_neck_cancer .
9133922	0	E-selectin	78,88	ICAM-3	62,68	E-selectin	ICAM-3	6401	3385	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
9378988	0	E-selectin	47,57	IFN-gamma	0,9	E-selectin	IFN-gamma	6401	3458	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IFN-gamma inhibits double-stranded RNA-induced E-selectin expression in human endothelial cells .
9064342	0	E-selectin	23,33	Interleukin-10	0,14	E-selectin	Interleukin-10	6401	3586	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-10 induces E-selectin on small and large blood vessel endothelial cells .
18761727	0	E-selectin	25,35	K1-3	12,16	E-selectin	K1-3	6401	3860	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiostatin K1-3 induces E-selectin via AP1 and Ets1 : a mediator for anti-angiogenic action of K1-3 .
18761727	0	E-selectin	25,35	K1-3	95,99	E-selectin	K1-3	6401	3860	Gene	Gene	START_ENTITY|dep|mediator mediator|nmod|action action|nmod|END_ENTITY	Angiostatin K1-3 induces E-selectin via AP1 and Ets1 : a mediator for anti-angiogenic action of K1-3 .
12165498	0	E-selectin	24,34	L-selectin	0,10	E-selectin	L-selectin	6401	6402	Gene	Gene	ligand|amod|START_ENTITY serves|nmod|ligand serves|nsubj|END_ENTITY	L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts .
12612222	0	E-selectin	8,18	L-selectin	28,38	E-selectin	L-selectin	6401	6402	Gene	Gene	START_ENTITY|appos|ICAM-1 ICAM-1|amod|END_ENTITY	Soluble E-selectin , soluble L-selectin and soluble ICAM-1 in bronchopulmonary_dysplasia , and changes with dexamethasone .
1374233	0	E-selectin	90,100	L-selectin	14,24	E-selectin	L-selectin	6401	6402	Gene	Gene	ligands|amod|START_ENTITY Le|nsubj|ligands bind|xcomp|Le ligand|parataxis|bind ligand|nsubj|Comparison Comparison|nmod|END_ENTITY	Comparison of L-selectin and E-selectin ligand specificities : the L-selectin can bind the E-selectin ligands sialyl Le -LRB- x -RRB- and sialyl Le -LRB- a -RRB- .
1374233	0	E-selectin	90,100	L-selectin	66,76	E-selectin	L-selectin	6401	6402	Gene	Gene	ligands|amod|START_ENTITY Le|nsubj|ligands bind|xcomp|Le bind|nsubj|END_ENTITY	Comparison of L-selectin and E-selectin ligand specificities : the L-selectin can bind the E-selectin ligands sialyl Le -LRB- x -RRB- and sialyl Le -LRB- a -RRB- .
15187162	0	E-selectin	78,88	L-selectin	27,37	E-selectin	L-selectin	6401	6402	Gene	Gene	capping|nmod|START_ENTITY capping|nmod|END_ENTITY	Shear-dependent capping of L-selectin and P-selectin_glycoprotein_ligand_1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils .
20564190	0	E-selectin	74,84	L-selectin	20,30	E-selectin	L-selectin	6401	6402	Gene	Gene	rolling|nmod|START_ENTITY neutrophil|acl|rolling neutrophil|amod|END_ENTITY	PI3K is involved in L-selectin - and PSGL-1-mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly .
23451187	0	E-selectin	65,75	L-selectin	108,118	E-selectin	L-selectin	6401	6402	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	P-selectin_glycoprotein_ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces .
8902148	0	E-selectin	77,87	L-selectin	8,18	E-selectin	L-selectin	6401	6402	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Soluble L-selectin in peripheral_arterial_disease : relationship with soluble E-selectin and soluble P-selectin .
8977216	0	E-selectin	42,52	L-selectin	23,33	E-selectin	L-selectin	6401	6402	Gene	Gene	than|nmod|START_ENTITY rolling|advmod|than kinetics|acl|rolling kinetics|nmod|END_ENTITY	The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength .
9024699	0	E-selectin	72,82	L-selectin	0,10	E-selectin	L-selectin	20339(Tax:10090)	6402	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	L-selectin from human , but not from mouse neutrophils binds directly to E-selectin .
9133922	0	E-selectin	78,88	L-selectin	90,100	E-selectin	L-selectin	6401	6402	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
7678223	0	E-selectin	27,37	Lewisx	79,85	E-selectin	Lewisx	6401	2526	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of surface E-selectin and the effect of soluble ligand -LRB- sialyl Lewisx -RRB- on the half-life of E-selectin .
11104809	0	E-selectin	72,82	P-Selectin_glycoprotein_ligand_1	0,32	E-selectin	P-Selectin glycoprotein ligand 1	20339(Tax:10090)	20345(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY physiological|acl|ligand physiological|nsubj|END_ENTITY	P-Selectin_glycoprotein_ligand_1 -LRB- PSGL-1 -RRB- is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration .
14978129	0	E-selectin	151,161	P-selectin_glycoprotein_ligand_1	116,148	E-selectin	P-selectin glycoprotein ligand 1	20339(Tax:10090)	20345(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Recruitment of IFN-gamma-producing -LRB- Th1-like -RRB- cells into the inflamed retina in vivo is preferentially regulated by P-selectin_glycoprotein_ligand_1 :P / E-selectin interactions .
24702436	0	E-selectin	68,78	TNF-a	41,46	E-selectin	TNF-a	6401	7124	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Sirtuin_1 stabilization by HuR represses TNF-a - and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro : relevance to human metabolic_syndrome .
11123285	0	E-selectin	64,74	TNF-alpha	46,55	E-selectin	TNF-alpha	6401	7124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|signal signal|nmod|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
12119193	0	E-selectin	40,50	TNF-alpha	73,82	E-selectin	TNF-alpha	6401	7124	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Lovastatin-stimulated superinduction of E-selectin , ICAM-1 and VCAM-1 in TNF-alpha activated human vascular endothelial cells .
19878508	0	E-selectin	35,45	TNF-alpha	11,20	E-selectin	TNF-alpha	6401	7124	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|antagonism antagonism|amod|END_ENTITY	Effects of TNF-alpha antagonism on E-selectin in obese subjects with metabolic_dysregulation .
7511636	0	E-selectin	130,140	TNF-alpha	104,113	E-selectin	TNF-alpha	20339(Tax:10090)	21926(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|recruitment recruitment|nmod|skin skin|acl|transplanted transplanted|nmod|mice mice|acl|induced induced|nmod|END_ENTITY	Leukocyte recruitment into human skin transplanted onto severe_combined_immunodeficient mice induced by TNF-alpha is dependent on E-selectin .
9441802	0	E-selectin	57,67	TNF-alpha	0,9	E-selectin	TNF-alpha	6401	7124	Gene	Gene	upregulate|dobj|START_ENTITY upregulate|nsubj|END_ENTITY	TNF-alpha and IL-1 upregulate membrane-bound and soluble E-selectin through a common pathway .
23457623	0	E-selectin	15,25	TWEAK	0,5	E-selectin	TWEAK	20339(Tax:10090)	21944(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	TWEAK enhances E-selectin and ICAM-1 expression , and may contribute to the development of cutaneous_vasculitis .
7683321	0	E-selectin	41,51	Transforming_growth_factor-beta	0,31	E-selectin	Transforming growth factor-beta	6401	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits E-selectin expression on human endothelial cells .
9888481	0	E-selectin	56,66	VCAM-1	106,112	E-selectin	VCAM-1	6401	7412	Gene	Gene	intercellular_adhesion_molecule_1|amod|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Circulating intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in head_and_neck_cancer .
15148373	0	E-selectin	0,10	endostatin	58,68	E-selectin	endostatin	6401	80781	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	E-selectin is required for the antiangiogenic activity of endostatin .
23039181	0	E-selectin	128,138	fucosyltransferase_VII	38,60	E-selectin	fucosyltransferase VII	20339(Tax:10090)	14347(Tax:10090)	Gene	Gene	generation|nmod|START_ENTITY END_ENTITY|nmod|generation	Differential regulation and impact of fucosyltransferase_VII and core 2 b1,6-N-acetyl-glycosaminyltransferase for generation of E-selectin and P-selectin ligands in murine CD4 + T cells .
16256043	0	E-selectin	42,52	hIL-4	15,20	E-selectin	hIL-4	6401	3565	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The effect of hIL-4 on the expression of E-selectin and ICAM-1 on bovine aortic endothelial cells -RSB- .
23403989	0	E-selectin	51,61	homeobox_A9	77,88	E-selectin	homeobox A9	6401	3205	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	shRNAs targeting high-mobility_group_box-1 inhibit E-selectin expression via homeobox_A9 in human umbilical vein endothelial cells .
26255015	0	E-selectin	66,76	homeobox_A9	92,103	E-selectin	homeobox A9	6401	3205	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- shRNAs targeting high_mobility_group_box-1 lead to inhibition of E-selectin expression via homeobox_A9 in human umbilical vein endothelial cells -RSB- .
9434632	0	E-selectin	8,18	intercellular_adhesion_molecule-1	28,61	E-selectin	intercellular adhesion molecule-1	6401	3383	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Soluble E-selectin enhances intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human tumor cell lines .
7506711	0	E-selectin	147,157	intercellular_adhesion_molecule_type_1	159,197	E-selectin	intercellular adhesion molecule type 1	6401	3383	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Estradiol enhances leukocyte binding to tumor_necrosis_factor -LRB- TNF -RRB- - stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin , intercellular_adhesion_molecule_type_1 , and vascular_cell_adhesion_molecule_type_1 .
19501916	0	E-selectin	80,90	monocyte_chemoattractant_protein-1	33,67	E-selectin	monocyte chemoattractant protein-1	6401	6347	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Interleukin-7 is associated with monocyte_chemoattractant_protein-1 and soluble E-selectin levels in peripheral blood of newly post-menopausal women .
11292614	0	E-selectin	29,39	mucin	14,19	E-selectin	mucin	6401	100508689	Gene	Gene	binds|nmod|START_ENTITY binds|compound|END_ENTITY	Human biliary mucin binds to E-selectin : a possible role in modulation of inflammation .
10974035	0	E-selectin	14,24	transforming_growth_factor_beta	44,75	E-selectin	transforming growth factor beta	6401	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of E-selectin gene expression by transforming_growth_factor_beta in endothelial cells involves coactivator integration of Smad and nuclear_factor_kappaB-mediated signals .
14669262	0	E-selectin	44,54	tumor_necrosis_factor-alpha	122,149	E-selectin	tumor necrosis factor-alpha	6401	7124	Gene	Gene	expression|amod|START_ENTITY flavonoids|nmod|expression effects|nmod|flavonoids stimulated|nsubj|effects stimulated|nmod|END_ENTITY	Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor_necrosis_factor-alpha .
17170373	0	E-selectin	73,83	tumor_necrosis_factor-alpha	87,114	E-selectin	tumor necrosis factor-alpha	6401	100009088(Tax:9986)	Gene	Gene	induction|nmod|START_ENTITY enhances|dobj|induction enhances|nmod|END_ENTITY	Vascular_endothelial_growth_factor synergistically enhances induction of E-selectin by tumor_necrosis_factor-alpha .
9848873	0	E-selectin	81,91	tumor_necrosis_factor-alpha	14,41	E-selectin	tumor necrosis factor-alpha	6401	7124	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha - and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents .
10556428	0	E-selectin_ligand_1	24,43	ESL-1	45,50	E-selectin ligand 1	ESL-1	20340(Tax:10090)	20340(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure of the murine E-selectin_ligand_1 -LRB- ESL-1 -RRB- gene and assignment to Chromosome 8 .
16905765	0	E-series_prostanoid-2	126,147	fibroblast_growth_factor_2	48,74	E-series prostanoid-2	fibroblast growth factor 2	5732	2247	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Seminal plasma and prostaglandin_E2 up-regulate fibroblast_growth_factor_2 expression in endometrial_adenocarcinoma cells via E-series_prostanoid-2 receptor-mediated transactivation of the epidermal_growth_factor_receptor and extracellular_signal-regulated_kinase pathway .
11238466	0	E10	27,30	bcl-10	107,113	E10	bcl-10	1461015(Tax:12657)	8915	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue , bcl-10 .
20503194	0	E12	102,105	RANBP16	18,25	E12	RANBP16	26767	23039	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12 .
18490918	0	E1A	89,92	CtBP2	128,133	E1A	CtBP2	25244(Tax:10116)	81717(Tax:10116)	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Inhibition of transcriptional activation and cell proliferation activities of adenovirus E1A by the unique N-terminal domain of CtBP2 .
3091845	0	E1A	114,117	c-myc	99,104	E1A	c-myc	25244(Tax:10116)	24577(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|amod|END_ENTITY	How reliable is amino_acid sequence homology in predicting similarity of structure and function of c-myc and Ad12 E1A oncogenic proteins ?
10567390	0	E1A-associated_protein_p300	40,67	cyclin_D1	18,27	E1A-associated protein p300	cyclin D1	2033	595	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Activation of the cyclin_D1 gene by the E1A-associated_protein_p300 through AP-1 inhibits cellular apoptosis .
10836994	0	E1AF	37,41	Hepatocyte_growth_factor	0,24	E1AF	Hepatocyte growth factor	2118	3082	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Hepatocyte_growth_factor upregulates E1AF that induces oral_squamous_cell_carcinoma cell invasion by activating matrix metalloproteinase genes .
7589255	0	E1B	92,95	Bcl-2	71,76	E1B	Bcl-2	6080	596	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Induction of p53-independent apoptosis by hygromycin_B : suppression by Bcl-2 and adenovirus E1B 19-kDa protein .
9467960	0	E1B	10,13	p53	62,65	E1B	p53	6080	7157	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus_infected cells .
18480432	0	E1B-AP5	11,18	ATR	22,25	E1B-AP5	ATR	11100	545	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	A role for E1B-AP5 in ATR signaling pathways during adenovirus_infection .
15907477	0	E1B-AP5	43,50	p53	56,59	E1B-AP5	p53	11100	7157	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of the hnRNP family member E1B-AP5 with p53 .
24186333	0	E1_and_E3	11,20	Atg3	70,74	E1 and E3	Atg3	6080;26765	64422	Gene	Gene	Binding|nmod|START_ENTITY Binding|nsubj|END_ENTITY	Binding to E1_and_E3 is mutually exclusive for the human autophagy E2 Atg3 .
1889817	0	E1_beta	104,111	BCKDHB	118,124	E1 beta	BCKDHB	594	594	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regional assignment of two genes of the human branched-chain alpha-keto_acid dehydrogenase complex : the E1_beta gene -LRB- BCKDHB -RRB- to chromosome 6p21-22 and the E2 gene -LRB- DBT -RRB- to chromosome 1p31 .
7326748	0	E1b	11,14	Ad12	29,33	E1b	Ad12	594	100188830	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets .
14527403	0	E2-25K	18,24	Hip-2	25,30	E2-25K	Hip-2	3093	3093	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Essential role of E2-25K / Hip-2 in mediating amyloid-beta neurotoxicity .
18710920	0	E2-25K	0,6	Hip-2	7,12	E2-25K	Hip-2	53323(Tax:10090)	53323(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	E2-25K / Hip-2 regulates caspase-12 in ER stress-mediated Abeta_neurotoxicity .
10636926	0	E2A	51,54	BETA2	21,26	E2A	BETA2	6929	4760	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter .
23536629	0	E2A	27,30	CD8	48,51	E2A	CD8	6929	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Id2-mediated inhibition of E2A represses memory CD8 + T cell differentiation .
1386162	0	E2A	45,48	HLF	34,37	E2A	HLF	6929	3131	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Fusion of the leucine zipper gene HLF to the E2A gene in human acute_B-lineage_leukemia .
1516826	0	E2A	92,95	Hlf	0,3	E2A	Hlf	6929	3131	Gene	Gene	fusion|nmod|START_ENTITY shows|advcl|fusion shows|nsubj|END_ENTITY	Hlf , a novel hepatic bZIP protein , shows altered DNA-binding properties following fusion to E2A in t -LRB- 17 ; 19 -RRB- acute_lymphoblastic_leukemia .
21857655	0	E2A	47,50	Id3	70,73	E2A	Id3	21423(Tax:10090)	15903(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells .
26029241	0	E2A	40,43	TCF3	34,38	E2A	TCF3	6929	6929	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sites of instability in the human TCF3 -LRB- E2A -RRB- gene adopt G-quadruplex DNA structures in vitro .
14627819	0	E2A	112,115	orphan_nuclear_receptor_SHP	36,63	E2A	orphan nuclear receptor SHP	6929	8431	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Synergistic activation of the human orphan_nuclear_receptor_SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1 .
24747958	0	E2A	70,73	uracil-DNA_glycosylase	30,52	E2A	uracil-DNA glycosylase	6929	7374	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression and recruitment of uracil-DNA_glycosylase are regulated by E2A during antibody diversification .
10228158	0	E2F	0,3	ORC1	56,60	E2F	ORC1	42550(Tax:7227)	35686(Tax:7227)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila .
8675008	0	E2F	44,47	cyclin_E	76,84	E2F	cyclin E	42550(Tax:7227)	34924(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	RBF , a novel RB-related gene that regulates E2F activity and interacts with cyclin_E in Drosophila .
15187102	0	E2F-1	63,68	Akt	30,33	E2F-1	Akt	1869	207	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin_A in breast_cancer cells .
16582100	0	E2F-1	25,30	BMI1	0,4	E2F-1	BMI1	1869	648	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas .
18096822	0	E2F-1	22,27	Bnip3	38,43	E2F-1	Bnip3	1869	664	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes .
19088195	0	E2F-1	14,19	Bnip3	30,35	E2F-1	Bnip3	1869	664	Gene	Gene	START_ENTITY|acl|regulated regulated|dobj|transcription transcription|amod|END_ENTITY	Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival .
7969176	0	E2F-1	32,37	CDK2	9,13	E2F-1	CDK2	1869	1017	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Cyclin_A / CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1 / DP-1 by phosphorylation .
17638884	0	E2F-1	75,80	CL100	31,36	E2F-1	CL100	1869	1843	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Dual_specificity_phosphatase_1 / CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress .
12717439	0	E2F-1	15,20	Chk2	0,4	E2F-1	Chk2	1869	11200	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Chk2 activates E2F-1 in response to DNA damage .
11549444	0	E2F-1	18,23	Cyclin_A	24,32	E2F-1	Cyclin A	1869	890	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Identification of E2F-1 / Cyclin_A antagonists .
8524253	0	E2F-1	0,5	DP-1	6,10	E2F-1	DP-1	1869	7027	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|END_ENTITY	E2F-1 : DP-1 induces p53 and overrides survival factors to trigger apoptosis .
12944911	0	E2F-1	64,69	FGF_receptor-2	14,28	E2F-1	FGF receptor-2	13555(Tax:10090)	14183(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of FGF_receptor-2 expression by transcription factor E2F-1 .
17482685	0	E2F-1	0,5	FOXO1	30,35	E2F-1	FOXO1	399489(Tax:10116)	84482(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	E2F-1 regulates expression of FOXO1 and FOXO3a .
15361834	0	E2F-1	11,16	ICBP90	0,6	E2F-1	ICBP90	1869	29128	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	ICBP90 , an E2F-1 target , recruits HDAC1 and binds to methyl-CpG through its SRA domain .
11042687	0	E2F-1	85,90	NPDC-1	0,6	E2F-1	NPDC-1	1869	56654	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	NPDC-1 , a regulator of neural cell proliferation and differentiation , interacts with E2F-1 , reduces its binding to DNA and modulates its transcriptional activity .
17471234	0	E2F-1	41,46	PAC1	0,4	E2F-1	PAC1	1869	1844	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	PAC1 is a direct transcription target of E2F-1 in apoptotic signaling .
16741925	0	E2F-1	40,45	Pur-alpha	18,27	E2F-1	Pur-alpha	1869	5813	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|amod|END_ENTITY	Regulation of the Pur-alpha promoter by E2F-1 .
7478595	0	E2F-1	14,19	Rb2	45,48	E2F-1	Rb2	1869	5934	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of E2F-1 gene expression by p130 -LRB- Rb2 -RRB- and D-type cyclin kinase activity .
10634932	0	E2F-1	30,35	alpha-pal	55,64	E2F-1	alpha-pal	1869	4899	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Transcriptional regulation of E2F-1 and eIF-2 genes by alpha-pal : a potential mechanism for coordinated regulation of protein synthesis , growth , and the cell cycle .
19303924	0	E2F-1	75,80	fibroblast_growth_factor_receptor_1	36,71	E2F-1	fibroblast growth factor receptor 1	1869	2260	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of human fibroblast_growth_factor_receptor_1 by E2F-1 .
23583198	0	E2F-1	52,57	miR-17-5p	14,23	E2F-1	miR-17-5p	1869	406952	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|END_ENTITY	Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular_carcinoma and enhancement of cell growth upon reversing this expression pattern .
22480684	0	E2F-1	19,24	p53	63,66	E2F-1	p53	1869	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response .
20616879	0	E2F-1	0,5	pRb	27,30	E2F-1	pRb	1869	5925	Gene	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity .
20976175	0	E2F-1	0,5	thrombospondin_1	25,41	E2F-1	thrombospondin 1	1869	7057	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	E2F-1 directly regulates thrombospondin_1 expression .
7958924	0	E2F-4	0,5	p107	75,79	E2F-4	p107	1874	5933	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	E2F-4 , a new member of the E2F transcription factor family , interacts with p107 .
7958925	0	E2F-4	0,5	p107	87,91	E2F-4	p107	1874	5933	Gene	Gene	has|nsubj|START_ENTITY has|dobj|activity activity|nmod|END_ENTITY	E2F-4 , a new member of the E2F gene family , has oncogenic activity and associates with p107 in vivo .
8657117	0	E2F-4	0,5	p107	28,32	E2F-4	p107	1874	5933	Gene	Gene	switches|nsubj|START_ENTITY switches|nmod|p130 p130|nmod|END_ENTITY	E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry .
10208422	0	E2F-4	98,103	p130	118,122	E2F-4	p130	1874	9221	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4 / pRB and E2F-4 / p130 complexes .
12006580	0	E2F-4	79,84	p130	41,45	E2F-4	p130	1874	5934	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Distinct phosphorylation events regulate p130 - and p107-mediated repression of E2F-4 .
8657117	0	E2F-4	0,5	p130	20,24	E2F-4	p130	1874	5934	Gene	Gene	switches|nsubj|START_ENTITY switches|nmod|END_ENTITY	E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry .
26503019	0	E2F1	37,41	ADAM12	14,20	E2F1	ADAM12	1869	8038	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of ADAM12 is regulated by E2F1 in small_cell_lung_cancer .
12082524	0	E2F1	77,81	ARF	14,17	E2F1	ARF	13555(Tax:10090)	1029	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|Activation Activation|nmod|END_ENTITY	Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2 .
26722215	0	E2F1	72,76	ATAD5	47,52	E2F1	ATAD5	1869	79915	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Hepatitis_B_Virus X Protein Upregulates hELG1 / ATAD5 Expression through E2F1 in Hepatocellular_Carcinoma .
17570542	0	E2F1	15,19	Alien	0,5	E2F1	Alien	1869	9318	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Alien inhibits E2F1 gene expression and cell proliferation .
16476732	0	E2F1	59,63	Apoptosis_signal-regulating_kinase_1	0,36	E2F1	Apoptosis signal-regulating kinase 1	1869	4217	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Apoptosis_signal-regulating_kinase_1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity .
18624722	0	E2F1	23,27	B-Myb	14,19	E2F1	B-Myb	1869	4605	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of B-Myb by E2F1 in hepatocellular_carcinoma .
19629135	0	E2F1	89,93	BIN1	52,56	E2F1	BIN1	1869	274	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage .
26891801	0	E2F1	0,4	CD147	67,72	E2F1	CD147	1869	682	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	E2F1 promotes tumor cell invasion and migration through regulating CD147 in prostate_cancer .
22880102	0	E2F1	58,62	CD2AP	40,45	E2F1	CD2AP	1869	23607	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional activation of the human CD2AP promoter by E2F1 .
23542171	0	E2F1	35,39	CTSL2	0,5	E2F1	CTSL2	1869	1515	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis .
22580462	0	E2F1	14,18	Cdh1	28,32	E2F1	Cdh1	1869	999	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation .
18562691	0	E2F1	72,76	E2F6	0,4	E2F1	E2F6	1869	1876	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	E2F6 inhibits cobalt_chloride-mimetic hypoxia-induced apoptosis through E2F1 .
26598524	0	E2F1	80,84	E2_Promoter_Binding_Factor_1	50,78	E2F1	E2 Promoter Binding Factor 1	1869	1869	Gene	Gene	Pathway|appos|START_ENTITY Pathway|compound|END_ENTITY	The Retinoblastoma Tumor Suppressor Protein -LRB- pRb -RRB- / E2_Promoter_Binding_Factor_1 -LRB- E2F1 -RRB- Pathway as a Novel Mediator of Transforming_Growth_Factor-b -LRB- TGFb -RRB- - Induced Autophagy .
16254079	0	E2F1	63,67	Ebp1	26,30	E2F1	Ebp1	1869	5036	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription .
20215421	0	E2F1	28,32	Estrogen_receptor	0,17	E2F1	Estrogen receptor	1869	2099	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Estrogen_receptor regulates E2F1 expression to mediate tamoxifen resistance .
17050006	0	E2F1	40,44	Glycogen_synthase_kinase-3beta	0,30	E2F1	Glycogen synthase kinase-3beta	1869	2932	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta binds to E2F1 and regulates its transcriptional activity .
24882622	0	E2F1	59,63	HBXIP	16,21	E2F1	HBXIP	1869	10542	Gene	Gene	modulating|dobj|START_ENTITY END_ENTITY|advcl|modulating	The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells .
17704056	0	E2F1	14,18	KAP1	55,59	E2F1	KAP1	1869	10155	Gene	Gene	Regulation|nmod|START_ENTITY function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of E2F1 function by the nuclear corepressor KAP1 .
19176033	0	E2F1	73,77	KIR3DL1	25,32	E2F1	KIR3DL1	1869	3811	Gene	Gene	-RSB-|compound|START_ENTITY expression|nmod|-RSB- expression|compound|END_ENTITY	-LSB- Molecular regulation of KIR3DL1 gene expression by transcription factor E2F1 -RSB- .
17980157	0	E2F1	37,41	LEF-1	0,5	E2F1	LEF-1	1869	51176	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	LEF-1 activates the transcription of E2F1 .
23542036	0	E2F1	35,39	MDR1	18,22	E2F1	MDR1	1869	5243	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the MDR1 promoter by E2F1 and EAPP .
25139024	0	E2F1	16,20	MiR-136	0,7	E2F1	MiR-136	1869	406927	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells .
25901521	0	E2F1	64,68	MicroRNA-320	0,12	E2F1	MicroRNA-320	1869	407037	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1 .
17178835	0	E2F1	60,64	Neuropilin-1	0,12	E2F1	Neuropilin-1	13555(Tax:10090)	18186(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral_ischemia-induced neuronal_death in vivo .
21602887	0	E2F1	64,68	PAX8	0,4	E2F1	PAX8	1869	7849	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein .
22798430	0	E2F1	44,48	RBM38	0,5	E2F1	RBM38	1869	55544	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	RBM38 is a direct transcriptional target of E2F1 that limits E2F1-induced proliferation .
24891616	0	E2F1	14,18	RORa	0,4	E2F1	RORa	1869	6095	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	RORa binds to E2F1 to inhibit cell proliferation and regulate mammary gland branching morphogenesis .
18039672	0	E2F1	28,32	RhoBTB2	0,7	E2F1	RhoBTB2	1869	23221	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	RhoBTB2 -LRB- DBC2 -RRB- is a mitotic E2F1 target gene with a novel role in apoptosis .
17483325	0	E2F1	99,103	S-phase_kinase-associated_protein_2	45,80	E2F1	S-phase kinase-associated protein 2	1869	6502	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Phosphoinositide-3-kinase signaling controls S-phase_kinase-associated_protein_2 transcription via E2F1 in pancreatic_ductal_adenocarcinoma cells .
23352642	0	E2F1	76,80	Skp2	35,39	E2F1	Skp2	1869	6502	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|acl|activating	The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast_cancer cells .
19115249	0	E2F1	27,31	Sp1	98,101	E2F1	Sp1	1869	6667	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites .
12697828	0	E2F1	14,18	TopBP1	53,59	E2F1	TopBP1	1869	11073	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of E2F1 by BRCT domain-containing protein TopBP1 .
23833190	0	E2F1	73,77	UHRF2	20,25	E2F1	UHRF2	1869	115426	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis .
18348985	0	E2F1	0,4	XRCC1	45,50	E2F1	XRCC1	100758556	100689414	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair .
18524851	0	E2F1	39,43	aryl_hydrocarbon_receptor	4,29	E2F1	aryl hydrocarbon receptor	1869	196	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor binds to E2F1 and inhibits E2F1-induced apoptosis .
15766563	0	E2F1	0,4	axin2	58,63	E2F1	axin2	1869	8313	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation .
18794899	0	E2F1	0,4	beta-catenin	15,27	E2F1	beta-catenin	1869	1499	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8 .
10329431	0	E2F1	90,94	cyclin_A	69,77	E2F1	cyclin A	1869	890	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
10329431	0	E2F1	90,94	cyclin_A	95,103	E2F1	cyclin A	1869	890	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
10446910	0	E2F1	30,34	estrogen_receptor	111,128	E2F1	estrogen receptor	1869	2099	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression regulated|nsubjpass|activation regulated|nmod|interactions interactions|compound|END_ENTITY	Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1 / estrogen_receptor interactions .
26722215	0	E2F1	72,76	hELG1	40,45	E2F1	hELG1	1869	79915	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dep|Expression	Hepatitis_B_Virus X Protein Upregulates hELG1 / ATAD5 Expression through E2F1 in Hepatocellular_Carcinoma .
27028861	0	E2F1	0,4	hHR23A	23,29	E2F1	hHR23A	1869	5886	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	E2F1 interactions with hHR23A inhibit its degradation and promote DNA repair .
19491197	0	E2F1	88,92	hypermethylated_in_cancer_1	26,53	E2F1	hypermethylated in cancer 1	1869	3090	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The tumor suppressor gene hypermethylated_in_cancer_1 is transcriptionally regulated by E2F1 .
25341426	0	E2F1	0,4	miR-224	13,20	E2F1	miR-224	1869	407009	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	E2F1 induces miR-224 / 452 expression to drive EMT through TXNIP downregulation .
11883935	0	E2F1	69,73	p14	57,60	E2F1	p14	1869	1029	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of the human tumor suppressor p14 -LRB- ARF -RRB- by E2F1 , E2F2 , E2F3 , and Sp1-like factors .
19115249	0	E2F1	27,31	p14ARF	41,47	E2F1	p14ARF	1869	1029	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activation activation|amod|END_ENTITY	8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites .
12077144	0	E2F1	96,100	p18INK4c	58,66	E2F1	p18INK4c	1869	1031	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1 .
22476863	0	E2F1	0,4	p19INK4d	13,21	E2F1	p19INK4d	13555(Tax:10090)	12581(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	E2F1 induces p19INK4d , a protein involved in the DNA damage response , following UV irradiation .
15713665	0	E2F1	36,40	p27Kip1	14,21	E2F1	p27Kip1	13555(Tax:10090)	12576(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|Expression Expression|amod|END_ENTITY	Activation of p27Kip1 Expression by E2F1 .
10766769	0	E2F1	0,4	p53	85,88	E2F1	p53	1869	7157	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|independent independent|nmod|END_ENTITY	E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase_3 .
12080472	0	E2F1	31,35	p53	19,22	E2F1	p53	13555(Tax:10090)	22060(Tax:10090)	Gene	Gene	transactivation|nummod|START_ENTITY induces|dobj|transactivation induces|nsubj|inhibition inhibition|nmod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
12101227	0	E2F1	0,4	p53	32,35	E2F1	p53	13555(Tax:10090)	22060(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis .
12101227	0	E2F1	0,4	p53	60,63	E2F1	p53	13555(Tax:10090)	22060(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|acl:relcl|coincident coincident|nmod|accumulation accumulation|compound|END_ENTITY	E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis .
12625370	0	E2F1	0,4	p53	25,28	E2F1	p53	1869	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	E2F1 activates the human p53 promoter and overcomes the repressive effect of hepatitis_B viral X protein -LRB- Hbx -RRB- on the p53 promoter .
15140942	0	E2F1	0,4	p53	46,49	E2F1	p53	1869	7157	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|ATM ATM|acl|signaling signaling|xcomp|induce induce|dobj|phosphorylation phosphorylation|compound|END_ENTITY	E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis .
16037820	0	E2F1	49,53	p53	82,85	E2F1	p53	1869	7157	Gene	Gene	p53|nmod|START_ENTITY retention|nmod|p53 requires|nsubj|retention requires|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315 .
17146434	0	E2F1	127,131	p53	109,112	E2F1	p53	1869	7157	Gene	Gene	activating|dobj|START_ENTITY enhances|advcl|activating enhances|dobj|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1 .
17690688	0	E2F1	85,89	p53	67,70	E2F1	p53	1869	7157	Gene	Gene	inhibits|dobj|START_ENTITY target|acl:relcl|inhibits target|nmod|END_ENTITY	The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1 .
19783986	0	E2F1	54,58	p53	49,52	E2F1	p53	1869	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|ccomp|axis axis|dobj|END_ENTITY	The execution of the transcriptional axis mutant p53 , E2F1 and ID4 promotes tumor neo-angiogenesis .
20805247	0	E2F1	28,32	p53	49,52	E2F1	p53	1869	7157	Gene	Gene	transactivation|nmod|START_ENTITY inhibited|nsubjpass|transactivation inhibited|nmod|END_ENTITY	MEF/ELF4 transactivation by E2F1 is inhibited by p53 .
20952509	0	E2F1	86,90	p53	74,77	E2F1	p53	1869	7157	Gene	Gene	upregulation|compound|START_ENTITY expressing|nmod|upregulation expressing|dobj|END_ENTITY	Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation .
21656380	0	E2F1	50,54	p53	70,73	E2F1	p53	1869	7157	Gene	Gene	independent|nsubj|START_ENTITY independent|nmod|status status|compound|END_ENTITY	MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status .
23954287	0	E2F1	0,4	p53	15,18	E2F1	p53	1869	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	E2F1 activates p53 transcription through its distal site and participates in apoptosis induction in HPV-positive cells .
9671769	0	E2F1	10,14	p53	85,88	E2F1	p53	13555(Tax:10090)	22060(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY induces|nsubj|activity induces|ccomp|heterozygous heterozygous|nmod|END_ENTITY	Increased E2F1 activity induces skin_tumors in mice heterozygous and nullizygous for p53 .
25312903	0	E2F1	0,4	p53R2	15,20	E2F1	p53R2	1869	50484	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	E2F1 regulates p53R2 gene expression in p53-deficient cells .
24793496	0	E2F2	94,98	miR-155	0,7	E2F2	miR-155	1870	406947	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-155 regulates the proliferation and cell cycle of colorectal_carcinoma cells by targeting E2F2 .
26967247	0	E2F2	103,107	miR-155	0,7	E2F2	miR-155	1870	406947	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-155 regulates the proliferation and invasion of clear_cell_renal_cell_carcinoma cells by targeting E2F2 .
25362258	0	E2F2	65,69	miR-31	0,6	E2F2	miR-31	1870	407035	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-31 promotes proliferation of colon_cancer cells by targeting E2F2 .
20889924	0	E2F3	38,42	C/EBPa	0,6	E2F3	C/EBPa	1871	1050	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	C/EBPa regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations .
25889255	0	E2F3	16,20	MiR-377	0,7	E2F3	MiR-377	1871	494326	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma .
25889255	0	E2F3	16,20	MiR-377	0,7	E2F3	MiR-377	1871	494326	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma .
22391204	0	E2F3	37,41	Rad18	0,5	E2F3	Rad18	1871	56852	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Rad18 is a transcriptional target of E2F3 .
26722476	0	E2F3	98,102	miR-503	0,7	E2F3	miR-503	1871	574506	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-503 inhibits cell proliferation and induces apoptosis in colorectal_cancer cells by targeting E2F3 .
25727014	0	E2F3a	40,45	Oct3/4	0,6	E2F3a	Oct3/4	13557(Tax:10090)	18999(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oct3/4 directly regulates expression of E2F3a in mouse embryonic stem cells .
19433082	0	E2F4	0,4	pRB	21,24	E2F4	pRB	104394(Tax:10090)	19645(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	E2F4 cooperates with pRB in the development of extra-embryonic tissues .
20586193	0	E2F4	63,67	pRb	10,13	E2F4	pRb	1874	5925	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|mutation mutation|compound|END_ENTITY	-LSB- A pocket pRb mutation induces the increase in its affinity to E2F4 coupled with activation of muscle differentiation -RSB- .
12909625	0	E2F6	0,4	BRCA1	26,31	E2F6	BRCA1	1876	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9 .
23082233	0	E2F6	0,4	BRG1	21,25	E2F6	BRG1	1876	6597	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	E2F6 associates with BRG1 in transcriptional regulation .
23954429	0	E2F6	14,18	Chk1	0,4	E2F6	Chk1	1876	1111	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription .
18562691	0	E2F6	0,4	E2F1	72,76	E2F6	E2F1	1876	1869	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	E2F6 inhibits cobalt_chloride-mimetic hypoxia-induced apoptosis through E2F1 .
17001316	0	E2F6	57,61	PHC3	0,4	E2F6	PHC3	1876	80012	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	PHC3 , a component of the hPRC-H complex , associates with E2F6 during G0 and is lost in osteosarcoma_tumors .
22903062	0	E2F7	0,4	VEGFA	73,78	E2F7	VEGFA	567941(Tax:7955)	30682(Tax:7955)	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|activation activation|nmod|END_ENTITY	E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1 .
22010578	0	E2FBP1	0,6	p16	23,26	E2FBP1	p16	1820	1029	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	E2FBP1 antagonizes the p16 -LRB- INK4A -RRB- - Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic_leukemia_protein stability .
26598524	0	E2_Promoter_Binding_Factor_1	50,78	E2F1	80,84	E2 Promoter Binding Factor 1	E2F1	1869	1869	Gene	Gene	Pathway|compound|START_ENTITY Pathway|appos|END_ENTITY	The Retinoblastoma Tumor Suppressor Protein -LRB- pRb -RRB- / E2_Promoter_Binding_Factor_1 -LRB- E2F1 -RRB- Pathway as a Novel Mediator of Transforming_Growth_Factor-b -LRB- TGFb -RRB- - Induced Autophagy .
21468579	0	E2_protein	37,47	IL-10	0,5	E2 protein	IL-10	7320	3586	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	IL-10 expression is regulated by HPV E2_protein in cervical cancer cells .
16182283	0	E3B1	0,4	Abi-1	50,55	E3B1	Abi-1	10006	11308(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	E3B1 , a human homologue of the mouse gene product Abi-1 , sensitizes activation of Rap1 in response to epidermal growth factor .
10893422	0	E3KARP	0,6	cystic_fibrosis_transmembrane_conductance_regulator	71,122	E3KARP	cystic fibrosis transmembrane conductance regulator	9351	1080	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	E3KARP mediates the association of ezrin and protein kinase A with the cystic_fibrosis_transmembrane_conductance_regulator in airway cells .
18502465	0	E3L	40,43	Huh7	73,77	E3L	Huh7	3707592(Tax:10245)	284424	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Antagonizing activity of vaccinia_virus E3L against human interferons in Huh7 cells .
9007060	0	E3L	50,53	RNase_III	83,92	E3L	RNase III	3707592(Tax:10245)	29102	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Complementation of deletion of the vaccinia_virus E3L gene by the Escherichia_coli RNase_III gene .
25560411	0	E3_Ubiquitin_Ligase	0,19	CD4	51,54	E3 Ubiquitin Ligase	CD4	68350(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
23665906	0	E3_Ubiquitin_Ligase	12,31	Cbl	32,35	E3 Ubiquitin Ligase	Cbl	158506	867	Gene	Gene	Proteins|compound|START_ENTITY Proteins|compound|END_ENTITY	The Role of E3_Ubiquitin_Ligase Cbl Proteins in b-Elemene Reversing Multi-Drug Resistance of Human Gastric_Adenocarcinoma Cells .
25560411	0	E3_Ubiquitin_Ligase	0,19	Cbl-b	20,25	E3 Ubiquitin Ligase	Cbl-b	68350(Tax:10090)	208650(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
26021757	0	E3_Ubiquitin_Ligase	30,49	Cullin_4A	4,13	E3 Ubiquitin Ligase	Cullin 4A	158506	8451	Gene	Gene	Mediates|nsubj|START_ENTITY END_ENTITY|parataxis|Mediates	The Cullin_4A / B-DDB1-Cereblon E3_Ubiquitin_Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels .
26021757	0	E3_Ubiquitin_Ligase	30,49	Cullin_4A	4,13	E3 Ubiquitin Ligase	Cullin 4A	158506	8451	Gene	Gene	Mediates|nsubj|START_ENTITY END_ENTITY|parataxis|Mediates	The Cullin_4A / B-DDB1-Cereblon E3_Ubiquitin_Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels .
26389696	0	E3_Ubiquitin_Ligase	28,47	ERa	9,12	E3 Ubiquitin Ligase	ERa	158506	2099	Gene	Gene	Activity|amod|START_ENTITY Stimulates|dobj|Activity Stimulates|nsubj|END_ENTITY	Liganded ERa Stimulates the E3_Ubiquitin_Ligase Activity of UBE3C to Facilitate Cell Proliferation .
26542806	0	E3_Ubiquitin_Ligase	0,19	Fbw7	20,24	E3 Ubiquitin Ligase	Fbw7	158506	55294	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|compound|END_ENTITY	E3_Ubiquitin_Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation .
25560411	0	E3_Ubiquitin_Ligase	0,19	Foxp3	104,109	E3 Ubiquitin Ligase	Foxp3	68350(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|nmod|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
26542806	0	E3_Ubiquitin_Ligase	0,19	Runx2	86,91	E3 Ubiquitin Ligase	Runx2	158506	860	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	E3_Ubiquitin_Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation .
26389696	0	E3_Ubiquitin_Ligase	28,47	UBE3C	60,65	E3 Ubiquitin Ligase	UBE3C	158506	9690	Gene	Gene	Activity|amod|START_ENTITY Activity|nmod|END_ENTITY	Liganded ERa Stimulates the E3_Ubiquitin_Ligase Activity of UBE3C to Facilitate Cell Proliferation .
16606853	0	E3_ubiquitin_ligase	59,78	BBS11	113,118	E3 ubiquitin ligase	BBS11	158506	1194518(Tax:224326)	Gene	Gene	START_ENTITY|nmod|gene gene|appos|END_ENTITY	Homozygosity mapping with SNP arrays identifies TRIM32 , an E3_ubiquitin_ligase , as a Bardet-Biedl_syndrome gene -LRB- BBS11 -RRB- .
15210761	0	E3_ubiquitin_ligase	46,65	CD4	104,107	E3 ubiquitin ligase	CD4	68350(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|appos|START_ENTITY anergy|nmod|lymphocytes related|xcomp|anergy gene|acl|related necessary|nsubj|gene necessary|nmod|induction induction|nmod|cells cells|compound|END_ENTITY	The gene related to anergy in lymphocytes , an E3_ubiquitin_ligase , is necessary for anergy induction in CD4 T cells .
15308098	0	E3_ubiquitin_ligase	22,41	Cbl-b	42,47	E3 ubiquitin ligase	Cbl-b	68350(Tax:10090)	208650(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	Essential role of the E3_ubiquitin_ligase Cbl-b in T cell anergy induction .
26300253	0	E3_ubiquitin_ligase	16,35	Cbl-b	36,41	E3 ubiquitin ligase	Cbl-b	158506	868	Gene	Gene	Suppression|nmod|START_ENTITY END_ENTITY|nsubj|Suppression	-LSB- Suppression of E3_ubiquitin_ligase Cbl-b in interleukin-1 signaling -RSB- .
20504295	0	E3_ubiquitin_ligase	58,77	Spartin	0,7	E3 ubiquitin ligase	Spartin	158506	23111	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Spartin activates atrophin-1-interacting_protein_4 -LRB- AIP4 -RRB- E3_ubiquitin_ligase and promotes ubiquitination of adipophilin on lipid droplets .
19995937	0	E3_ubiquitin_ligase	16,35	aurora_B	44,52	E3 ubiquitin ligase	aurora B	158506	9212	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	The Cul3-KLHL21 E3_ubiquitin_ligase targets aurora_B to midzone microtubules in anaphase and is required for cytokinesis .
19801649	0	E47	57,60	Mixed_lineage_kinase	0,20	E47	Mixed lineage kinase	6929	9175	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Mixed_lineage_kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal_death and survival pathways .
9671474	0	E47	52,55	Pip	21,24	E47	Pip	6929	5304	Gene	Gene	enhance|nmod|START_ENTITY enhance|nsubj|END_ENTITY	Transcription factor Pip can enhance DNA binding by E47 , leading to transcriptional synergy involving multiple protein domains .
17242194	0	E47	27,30	VE-cadherin	52,63	E47	VE-cadherin	6929	1003	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	TAL-1 / SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells .
17274955	0	E4BP4	34,39	PERIOD2	83,90	E4BP4	PERIOD2	4783	8864	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2 .
16652157	0	E4F1	53,57	FHL2	21,25	E4F1	FHL2	1877	2274	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The LIM-only protein FHL2 is a negative regulator of E4F1 .
7590737	0	E4TF1-60	49,57	GABPA	42,47	E4TF1-60	GABPA	2551	2551	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mapping of the human transcription factor GABPA -LRB- E4TF1-60 -RRB- gene to chromosome 21 .
15087429	0	E4bp4	28,33	Parathyroid_hormone	0,19	E4bp4	Parathyroid hormone	18030(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Parathyroid_hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic_adenosine_3 ' ,5 ' - monophosphate signaling in osteoblasts .
9143503	0	E6-AP	10,15	UBE3A	22,27	E6-AP	UBE3A	7337	7337	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human E6-AP gene -LRB- UBE3A -RRB- encodes three potential protein isoforms generated by differential splicing .
23751361	0	E6-AP	176,181	a-synuclein	205,216	E6-AP	a-synuclein	7337	6622	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Reynosin protects against neuronal_toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson 's _ disease : Reciprocal up-regulation of E6-AP and down-regulation of a-synuclein .
19645749	0	E6-AP	21,26	alpha-synuclein	51,66	E6-AP	alpha-synuclein	7337	6622	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein .
9293917	0	E6/E7	72,77	epidermal_growth_factor_receptor	14,46	E6/E7	epidermal growth factor receptor	25479186	1956	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor and human_papillomavirus E6/E7 proteins in cervical_carcinoma cells .
17023019	0	E6AP	15,19	UBE3A	21,26	E6AP	UBE3A	7337	7337	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of E6AP -LRB- UBE3A -RRB- with human papillomavirus type 11 E6 protein .
23581475	0	E6AP	21,25	c-Abl	0,5	E6AP	c-Abl	7337	25	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity .
12502878	0	E6TP1	75,80	Rap	94,97	E6TP1	Rap	26037	4043	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	The high-risk human papillomavirus_type_16 E6 counters the GAP function of E6TP1 toward small Rap G proteins .
15233798	0	E75	70,73	EcR	60,63	E75	EcR	692595(Tax:7091)	692756(Tax:7091)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR , HR3 , E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera .
15233798	0	E75	70,73	HR3	65,68	E75	HR3	692595(Tax:7091)	692562(Tax:7091)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR , HR3 , E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera .
6891400	3	EA3	102,105	EA5	134,137	EA3	EA5	780905	785	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure of EA3 and further purification of EA5 .
6891400	3	EA5	134,137	EA3	102,105	EA5	EA3	785	780905	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure of EA3 and further purification of EA5 .
7719709	0	EAA5	40,44	GluR7	46,51	EAA5	GluR7	2899	2899	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Molecular characterization of the human EAA5 -LRB- GluR7 -RRB- receptor : a high-affinity kainate receptor with novel potential RNA editing sites .
19998491	0	EAAT-2	60,66	GLT-1	54,59	EAAT-2	GLT-1	6506	6506	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Comparative structural and functional analysis of the GLT-1 / EAAT-2 promoter from man and rat .
26690923	0	EAAT1	61,66	Caveolin-1	0,10	EAAT1	Caveolin-1	398856(Tax:8355)	399006(Tax:8355)	Gene	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	Caveolin-1 Sensitivity of Excitatory Amino_Acid Transporters EAAT1 , EAAT2 , EAAT3 , and EAAT4 .
26233565	0	EAAT1	54,59	SPAK	85,89	EAAT1	SPAK	398856(Tax:8355)	446749(Tax:8355)	Gene	Gene	Down-Regulation|nmod|START_ENTITY Down-Regulation|nmod|END_ENTITY	Down-Regulation of Excitatory Amino_Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1 .
23032072	0	EAAT2	39,44	AQP4	60,64	EAAT2	AQP4	20511(Tax:10090)	11829(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Striatal adenosine signaling regulates EAAT2 and astrocytic AQP4 expression and alcohol drinking in mice .
20374202	0	EAAT2	33,38	ENT1	0,4	EAAT2	ENT1	20511(Tax:10090)	63959(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ENT1 regulates ethanol-sensitive EAAT2 expression and function in astrocytes .
24277080	0	EAAT2	33,38	GLT-1	27,32	EAAT2	GLT-1	20511(Tax:10090)	20511(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|dep|expression regulation|nmod|END_ENTITY	Differential regulation of GLT-1 / EAAT2 gene expression by NF-kB and N-myc in male mouse brain during postnatal development .
9771796	0	EAAT2	4,9	GLT-1	11,16	EAAT2	GLT-1	6506	6506	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The EAAT2 -LRB- GLT-1 -RRB- gene in motor_neuron_disease : absence of mutations in amyotrophic_lateral_sclerosis and a point mutation in patients with hereditary_spastic_paraplegia .
19328838	0	EAAT2	79,84	GLT1	73,77	EAAT2	GLT1	29482(Tax:10116)	29482(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The concentrations and distributions of three C-terminal variants of the GLT1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate_transporter protein in rat brain tissue suggest differential regulation .
15660126	0	EAAT2	36,41	N-myc	67,72	EAAT2	N-myc	6506	4613	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Positive and negative regulation of EAAT2 by NF-kappaB : a role for N-myc in TNFalpha-controlled repression .
24469401	0	EAAT2	51,56	Yin_Yang_1	0,10	EAAT2	Yin Yang 1	6506	7528	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Yin_Yang_1 is a repressor of glutamate_transporter EAAT2 , and it mediates manganese-induced decrease of EAAT2 expression in astrocytes .
21291865	0	EAAT2	32,37	adenosine_A1_receptor	57,78	EAAT2	adenosine A1 receptor	6506	134	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of ethanol-sensitive EAAT2 expression through adenosine_A1_receptor in astrocytes .
12742080	0	EAAT2	116,121	glutamate_transporter	88,109	EAAT2	glutamate transporter	29482(Tax:10116)	29483(Tax:10116)	Gene	Gene	pathways|nsubj|START_ENTITY Beta-amyloid|parataxis|pathways Beta-amyloid|appos|expression expression|nmod|GLT-1 GLT-1|compound|END_ENTITY	Beta-amyloid and brain-derived_neurotrophic_factor , BDNF , up-regulate the expression of glutamate_transporter GLT-1 / EAAT2 via different signaling pathways utilizing transcription factor NF-kappaB .
19328838	0	EAAT2	79,84	glutamate_transporter	94,115	EAAT2	glutamate transporter	29482(Tax:10116)	29483(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The concentrations and distributions of three C-terminal variants of the GLT1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate_transporter protein in rat brain tissue suggest differential regulation .
12446457	0	EAF1	56,60	EAF2	25,29	EAF1	EAF2	85403	55840	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	ELL-associated_factor_2 -LRB- EAF2 -RRB- , a functional homolog of EAF1 with alternative ELL binding properties .
20161747	0	EAF1	50,54	Wnt4	32,36	EAF1	Wnt4	415205(Tax:7955)	30123(Tax:7955)	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19 .
12446457	0	EAF2	25,29	EAF1	56,60	EAF2	EAF1	55840	85403	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	ELL-associated_factor_2 -LRB- EAF2 -RRB- , a functional homolog of EAF1 with alternative ELL binding properties .
14755728	0	EAOH	37,41	Aprataxin	0,9	EAOH	Aprataxin	54840	54840	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Aprataxin , the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein .
15511219	0	EAP20	94,99	CHMP6	6,11	EAP20	CHMP6	84313	79643	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human CHMP6 , a myristoylated ESCRT-III protein , interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting .
12743594	0	EAPII	0,5	ETS1	21,25	EAPII	ETS1	51567	2113	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	EAPII interacts with ETS1 and modulates its transcriptional function .
21572256	0	EAPP	0,4	p21	31,34	EAPP	p21	55837	644914	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	EAPP modulates the activity of p21 and Chk2 .
15962301	0	EAST	0,4	Megator	20,27	EAST	Megator	46006(Tax:7227)	36264(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	EAST interacts with Megator and localizes to the putative spindle matrix during mitosis in Drosophila .
16339536	0	EAT-2	48,53	CRACC	26,31	EAT-2	CRACC	117157	57823	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The cytotoxicity receptor CRACC -LRB- CS-1 -RRB- recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells .
11554924	0	EB1	119,122	BIM1	134,138	EB1	BIM1	22919	856736(Tax:4932)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	PKC1 , a protein kinase C homologue of Saccharomyces_cerevisiae , participates in microtubule function through the yeast EB1 homologue , BIM1 .
18590831	0	EB1	16,19	Bim1p	53,58	EB1	Bim1p	22919	856736(Tax:4932)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Giardia_lamblia EB1 is a functional homolog of yeast Bim1p that binds to microtubules .
21737685	0	EB1	22,25	Kif18B	0,6	EB1	Kif18B	22919	146909	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Kif18B interacts with EB1 and controls astral microtubule length during mitosis .
17968321	0	EB1	21,24	MCAK	0,4	EB1	MCAK	22919	11004	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	MCAK associates with EB1 .
20842219	0	EB1	52,55	RARRES1	17,24	EB1	RARRES1	22919	5918	Gene	Gene	Regulates|dobj|START_ENTITY Regulates|nsubj|END_ENTITY	Tumor Suppressor RARRES1 Regulates DLG2 , PP2A , VCP , EB1 , and Ankrd26 .
23687376	0	EB1	116,119	STIM1	19,24	EB1	STIM1	22919	6786	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1 .
8087622	0	EB1	68,71	TBP	107,110	EB1	TBP	22919	6908	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	The bZIP motif of the Epstein-Barr_virus _ -LRB- EBV -RRB- transcription factor EB1 mediates a direct interaction with TBP .
23572079	0	EB1/3	53,58	MAP1B	0,5	EB1/3	MAP1B	22919;22924	4131	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells .
16129689	0	EB2	57,60	SHARP	86,91	EB2	SHARP	10982	23013	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of the Epstein-Barr_virus mRNA export factor EB2 with human Spen proteins SHARP , OTT1 , and a novel member of the family , OTT3 , links Spen proteins with splicing regulation and mRNA export .
16129689	0	EB2	57,60	Spen	72,76	EB2	Spen	10982	23013	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Interaction of the Epstein-Barr_virus mRNA export factor EB2 with human Spen proteins SHARP , OTT1 , and a novel member of the family , OTT3 , links Spen proteins with splicing regulation and mRNA export .
23712260	0	EB3	29,32	Aurora_B	0,8	EB3	Aurora B	22924	9212	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Aurora_B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis .
15580294	0	EBF	56,59	Evi3	0,4	EBF	Evi3	13591(Tax:10090)	225207(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Evi3 , a zinc-finger protein related to EBFAZ , regulates EBF activity in B-cell_leukemia .
12077253	0	EBF	77,80	early_B_cell_factor	56,75	EBF	early B cell factor	1879	1879	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and characterization of a promoter flanking the early_B_cell_factor -LRB- EBF -RRB- gene indicates roles for E-proteins and autoregulation in the control of EBF expression .
23174882	0	EBF1	31,35	early_B-cell_factor_1	8,29	EBF1	early B-cell factor 1	1879	1879	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of early_B-cell_factor_1 -LRB- EBF1 -RRB- in Hodgkin_lymphoma .
10627863	0	EBI1	6,10	CCR7	0,4	EBI1	CCR7	1236	1236	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	CCR7 -LRB- EBI1 -RRB- receptor down-regulation in asthma : differential gene expression in human CD4 + T lymphocytes .
26694585	0	EBI3	0,4	Th1	16,19	EBI3	Th1	50498(Tax:10090)	57314(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	EBI3 suppresses Th1 , Th17 and Th2 immune responses after Trypanosoma_cruzi_infection and inhibits parasite replication by interfering with alternative macrophage activation .
20876453	0	EBNA-2	147,153	LMP-1	127,132	EBNA-2	LMP-1	17494192	17494204	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr_virus-encoded protein LMP-1 in absence of EBNA-2 : implications for the type II EBV latent gene expression in Hodgkin_lymphoma .
15627504	0	EBNA-2	9,15	p100	4,8	EBNA-2	p100	17494192	4940	Gene	Gene	coactivator|compound|START_ENTITY coactivator|amod|END_ENTITY	The p100 EBNA-2 coactivator : a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle .
18922874	0	EBNA1	4,9	Brd4	68,72	EBNA1	Brd4	17494214	23476	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The EBNA1 protein of Epstein-Barr_virus functionally interacts with Brd4 .
27009953	0	EBNA1	29,34	HCF1	0,4	EBNA1	HCF1	17494214	3054	Gene	Gene	Cooperate|nmod|START_ENTITY Cooperate|nsubj|END_ENTITY	HCF1 and OCT2 Cooperate with EBNA1 to Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr_Virus .
12719594	0	EBNA2	0,5	BATF	47,51	EBNA2	BATF	17494192	10538	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	EBNA2 and activated Notch induce expression of BATF .
10644367	0	EBNA2	19,24	SKIP	11,15	EBNA2	SKIP	17494192	80309	Gene	Gene	activation|compound|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	A role for SKIP in EBNA2 activation of CBF1-repressed promoters .
19032945	0	EBNA2	27,32	STAT3	43,48	EBNA2	STAT3	17494192	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Epstein-Barr_virus-derived EBNA2 regulates STAT3 activation .
7933133	0	EBNA2	115,120	TP1	48,51	EBNA2	TP1	17494192	7141	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Crucial sequences within the Epstein-Barr_virus TP1 promoter for EBNA2-mediated transactivation and interaction of EBNA2 with its responsive element .
7183436	0	EBP	42,45	Estramustine_binding_protein	12,40	EBP	Estramustine binding protein	117278(Tax:10116)	117278(Tax:10116)	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of Estramustine_binding_protein -LRB- EBP -RRB- in rat dorsal prostate by means of high pressure liquid chromatography .
23110497	0	EBP1	39,43	ERBB3_binding_protein_1	14,37	EBP1	ERBB3 binding protein 1	5036	5036	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ERBB3_binding_protein_1 -LRB- EBP1 -RRB- in salivary adenoid_cystic_carcinoma and its clinicopathological relevance .
20379846	0	EBP1	26,30	ErbB2	41,46	EBP1	ErbB2	18813(Tax:10090)	13866(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast_cancer cells .
2406459	0	EBP1	40,44	NF-kappa_B	46,56	EBP1	NF-kappa B	4790	4790	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of enhancer-binding protein EBP1 -LRB- NF-kappa_B -RRB- with the human_immunodeficiency_virus_type_1 enhancer .
10682683	0	EBP1	26,30	PA2G4	19,24	EBP1	PA2G4	5036	5036	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Interaction of the PA2G4 -LRB- EBP1 -RRB- protein with ErbB-3 and regulation of this binding by heregulin .
25492869	0	EBP50	67,72	Ezrin-Radixin-Moesin-Binding_Phosphoprotein_50	19,65	EBP50	Ezrin-Radixin-Moesin-Binding Phosphoprotein 50	9368	9368	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of Ezrin-Radixin-Moesin-Binding_Phosphoprotein_50 -LRB- EBP50 -RRB- by Akt Promotes Stability and Mitogenic Function of S-phase_Kinase_Associated_Protein-2 -LRB- Skp2 -RRB- .
20395446	0	EBP50	12,17	Podocalyxin	0,11	EBP50	Podocalyxin	9368	5420	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Podocalyxin EBP50 ezrin molecular complex enhances the metastatic potential of renal_cell_carcinoma through recruiting Rac1 guanine_nucleotide exchange factor ARHGEF7 .
26862730	0	EBP50	34,39	RSK1	14,18	EBP50	RSK1	9368	6195	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation .
1321787	0	EBV_receptor	103,115	CR2	98,101	EBV receptor	CR2	1380	1380	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Epstein-Barr_virus DNA in Reed-Sternberg cells of Hodgkin 's _ disease is frequently associated with CR2 -LRB- EBV_receptor -RRB- expression .
22251572	0	EC-SOD	0,6	COX-2	33,38	EC-SOD	COX-2	20657(Tax:10090)	17709(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	EC-SOD induces apoptosis through COX-2 and galectin-7 in the epidermis .
9290261	0	EC-SOD	52,58	extracellular_superoxide_dismutase	16,50	EC-SOD	extracellular superoxide dismutase	6649	6649	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism of extracellular_superoxide_dismutase -LRB- EC-SOD -RRB- gene : relation to the mutation responsible for high EC-SOD level in serum .
19199298	0	EC1	80,83	E-cadherin	100,110	EC1	E-cadherin	4819	999	Gene	Gene	domain|compound|START_ENTITY stability|nmod|domain role|nmod|stability role|nmod|END_ENTITY	The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin .
22531851	0	EC1	31,34	E-cadherin	45,55	EC1	E-cadherin	4819	999	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue .
26728967	0	EC1	55,58	E-cadherin	69,79	EC1	E-cadherin	4819	999	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Probing the interaction between cHAVc3 peptide and the EC1 domain of E-cadherin using NMR and molecular_dynamics simulations .
8934531	0	ECA39	0,5	Gcn4	63,67	ECA39	Gcn4	586	856709(Tax:4932)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	ECA39 is regulated by c-Myc in human and by a Jun/Fos homolog , Gcn4 , in yeast .
21896782	0	ECAT15-2	19,27	Dppa2	28,33	ECAT15-2	Dppa2	73703(Tax:10090)	73703(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Essential roles of ECAT15-2 / Dppa2 in functional lung development .
16540265	0	ECE-1	80,85	endothelin-converting_enzyme-1	48,78	ECE-1	endothelin-converting enzyme-1	230857(Tax:10090)	230857(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organisation of the mouse gene encoding endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- and mRNA expression of ECE-1 isoforms in murine tissues .
23911580	0	ECE-1	46,51	endothelin-converting_enzyme-1	14,44	ECE-1	endothelin-converting enzyme-1	94204(Tax:10116)	94204(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- by the calcimimetic R-568 .
25179465	0	ECE1	75,79	endothelin_converting_enzyme_1	43,73	ECE1	endothelin converting enzyme 1	1889	1889	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An arterial-specific enhancer of the human endothelin_converting_enzyme_1 -LRB- ECE1 -RRB- gene is synergistically activated by Sox17 , FoxC2 , and Etv2 .
10698686	0	ECEL1	55,60	XCE	62,65	ECEL1	XCE	9427	9427	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Organization and chromosomal localization of the human ECEL1 -LRB- XCE -RRB- gene encoding a zinc metallopeptidase involved in the nervous control of respiration .
1733667	0	ECGF1	84,89	endothelial_cell_growth_factor	52,82	ECGF1	endothelial cell growth factor	1890	1890	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regional localization of the human platelet-derived endothelial_cell_growth_factor -LRB- ECGF1 -RRB- gene to chromosome 22q13 .
23416296	0	ECHS1	0,5	STAT3	21,26	ECHS1	STAT3	1892	6774	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling .
9073515	0	ECHS1	46,51	enoyl-CoA_hydratase	20,39	ECHS1	enoyl-CoA hydratase	1892	1892	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human mitochondrial enoyl-CoA_hydratase gene -LRB- ECHS1 -RRB- : structural organization and assignment to chromosome 10q26.2-q26 .3 .
12603844	0	ECM1	37,41	Extracellular_matrix_protein_1	0,30	ECM1	Extracellular matrix protein 1	1893	1893	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Extracellular_matrix_protein_1 gene -LRB- ECM1 -RRB- mutations in lipoid_proteinosis and genotype-phenotype correlation .
25446258	0	ECM1	0,4	PKM2	68,72	ECM1	PKM2	1893	5315	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2 .
11929856	0	ECM1	103,107	extracellular_matrix_protein_1	66,96	ECM1	extracellular matrix protein 1	1893	1893	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lipoid_proteinosis maps to 1q21 and is caused by mutations in the extracellular_matrix_protein_1 gene -LRB- ECM1 -RRB- .
16225617	0	ECM1	61,65	extracellular_matrix_protein_1	24,54	ECM1	extracellular matrix protein 1	1893	1893	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	A novel mutation of the extracellular_matrix_protein_1 gene -LRB- ECM1 -RRB- in a patient with lipoid_proteinosis -LRB- Urbach-Wiethe_disease -RRB- from Sicily .
19275936	0	ECM1	0,4	fibulin-3	20,29	ECM1	fibulin-3	1893	2202	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain .
15821733	0	ECO1	75,79	ESCO2	43,48	ECO1	ESCO2	850584(Tax:4932)	157570	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Roberts_syndrome is caused by mutations in ESCO2 , a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion .
11699410	0	ECP	49,52	eosinophil_cationic_protein	20,47	ECP	eosinophil cationic protein	6037	6037	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	The serum levels of eosinophil_cationic_protein -LRB- ECP -RRB- are related to the infiltration of eosinophils in the tumours of patients with Hodgkin 's _ disease .
16434694	0	ECP	49,52	eosinophil_cationic_protein	54,81	ECP	eosinophil cationic protein	6037	6037	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A -LRB- G - > C -RRB- transversion in the 3 ' UTR of the human ECP -LRB- eosinophil_cationic_protein -RRB- gene correlates to the cellular content of ECP .
21679745	0	ECP	39,42	eosinophil_cationic_protein	10,37	ECP	eosinophil cationic protein	6037	6037	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of eosinophil_cationic_protein -LRB- ECP -RRB- on Hodgkin_lymphoma cell lines .
7976792	0	ECP	40,43	eosinophil_cationic_protein	11,38	ECP	eosinophil cationic protein	6037	6037	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of eosinophil_cationic_protein -LRB- ECP -RRB- in anaphylactoid anaesthetic reactions in vivo and in vitro .
8060919	0	ECP	70,73	eosinophil_cationic_protein	41,68	ECP	eosinophil cationic protein	6037	6037	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Serum soluble IL-2_receptor -LRB- sIL-2R -RRB- and eosinophil_cationic_protein -LRB- ECP -RRB- levels in atopic_dermatitis .
9250255	0	ECP	60,63	eosinophil_cationic_protein	31,58	ECP	eosinophil cationic protein	6037	6037	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Comparison of sputum and serum eosinophil_cationic_protein -LRB- ECP -RRB- levels in nonatopic asthma and chronic_obstructive_pulmonary_disease .
9578914	0	ECP	35,38	eosinophil_cationic_protein	6,33	ECP	eosinophil cationic protein	6037	6037	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum eosinophil_cationic_protein -LRB- ECP -RRB- levels in patients with seasonal_allergic_rhinitis and allergic_asthma .
15095404	0	ECRG1	61,66	Miz-1	92,97	ECRG1	Miz-1	339967	9063	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1 .
12646258	0	ECRG2	0,5	metallothionein_2A	103,121	ECRG2	metallothionein 2A	84651	4502	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ECRG2 , a novel candidate of tumor suppressor gene in the esophageal_carcinoma , interacts directly with metallothionein_2A and links to apoptosis .
21288367	0	ECRG4	30,35	TMPRSS11A	60,69	ECRG4	TMPRSS11A	84417	339967	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A -LRB- ECRG1 -RRB- to inhibit cancer cell growth in esophageal_carcinoma .
22588174	0	ECSIT	22,27	TRIM59	0,6	ECSIT	TRIM59	51295	286827	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRIM59 interacts with ECSIT and negatively regulates NF-kB and IRF-3 / 7-mediated signal pathways .
18556573	0	ECSM2	0,5	filamin_a	31,40	ECSM2	filamin a	641700	2316	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	ECSM2 , an endothelial specific filamin_a binding protein that mediates chemotaxis .
18511905	0	ECT2	28,32	Cyk-4	11,16	ECT2	Cyk-4	1894	3851	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis .
18842503	0	ECT2	20,24	ECT2	67,71	ECT2	ECT2	1894	1894	Gene	Gene	expression|compound|START_ENTITY expression|nmod|region region|compound|END_ENTITY	Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic_cancer .
18842503	0	ECT2	67,71	ECT2	20,24	ECT2	ECT2	1894	1894	Gene	Gene	region|compound|START_ENTITY expression|nmod|region expression|compound|END_ENTITY	Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic_cancer .
19996184	0	ECT2	40,44	Epithelial_cell_transforming_protein_2	0,38	ECT2	Epithelial cell transforming protein 2	13605(Tax:10090)	13605(Tax:10090)	Gene	Gene	depletion|appos|START_ENTITY depletion|amod|END_ENTITY	Epithelial_cell_transforming_protein_2 -LRB- ECT2 -RRB- depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles .
16651558	0	ECaC	60,64	epithelial_calcium_channel	32,58	ECaC	epithelial calcium channel	100136177(Tax:8022)	100136177(Tax:8022)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a branchial epithelial_calcium_channel -LRB- ECaC -RRB- in freshwater rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
24508088	0	EDA	24,27	Ectodysplasin_A	0,15	EDA	Ectodysplasin A	1896	1896	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Ectodysplasin_A -LRB- EDA -RRB- - EDA receptor signalling and its pharmacological modulation .
17765603	0	EDA	45,48	TNT	67,70	EDA	TNT	1896	162083	Gene	Gene	complexes|compound|START_ENTITY complexes|nmod|END_ENTITY	Absorption spectroscopic and FTIR studies on EDA complexes between TNT -LRB- 2,4,6-trinitrotoluene -RRB- with amines in DMSO and determination of the vertical electron affinity of TNT .
9736768	0	EDA	42,45	ectodermal_dysplasia	15,35	EDA	ectodermal dysplasia	1896	1896	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The anhidrotic ectodermal_dysplasia gene -LRB- EDA -RRB- undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats .
21091672	0	EDA	50,53	ectodysplasin-A	33,48	EDA	ectodysplasin-A	1896	1896	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel missense mutation in the ectodysplasin-A -LRB- EDA -RRB- gene underlies X-linked_recessive_nonsyndromic_hypodontia .
8587240	0	EDA	72,75	transforming_growth_factor_beta	94,125	EDA	transforming growth factor beta	1896	7040	Gene	Gene	variant|compound|START_ENTITY variant|nmod|END_ENTITY	Fibronectin synthesis in tubular epithelial cells : up-regulation of the EDA splice variant by transforming_growth_factor_beta .
20501644	0	EDA-A2	13,19	XEDAR	20,25	EDA-A2	XEDAR	1896	60401	Gene	Gene	Crosstalk|nmod|START_ENTITY END_ENTITY|dep|Crosstalk	Crosstalk of EDA-A2 / XEDAR in the p53 signaling pathway .
17125505	0	EDAR	0,4	ectodermal_dysplasia	49,69	EDAR	ectodermal dysplasia	10913	1896	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	EDAR mutation in autosomal dominant hypohidrotic ectodermal_dysplasia in two Swedish families .
20051463	0	EDC3	82,86	AKT_and_14-3-3	53,67	EDC3	AKT and 14-3-3	80153	207;10971	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Global phosphoproteomics identifies a major role for AKT_and_14-3-3 in regulating EDC3 .
17923697	0	EDC3	23,27	DCP1	46,50	EDC3	DCP1	80153	196513	Gene	Gene	binding|compound|START_ENTITY binding|compound|END_ENTITY	A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting .
24858563	0	EDC4	22,26	CCHCR1	0,6	EDC4	CCHCR1	23644	54535	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CCHCR1 interacts with EDC4 , suggesting its localization in P-bodies .
17074762	0	EDD	0,3	CHK2	46,50	EDD	CHK2	51366	11200	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	EDD mediates DNA damage-induced activation of CHK2 .
16431915	0	EDEM	17,21	EDEM3	0,5	EDEM	EDEM3	9695	80267	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	EDEM3 , a soluble EDEM homolog , enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming .
24200403	0	EDEM1	32,37	EDEM2	12,17	EDEM1	EDEM2	9695	55741	Gene	Gene	compared|nmod|START_ENTITY compared|nsubj|role role|nmod|END_ENTITY	The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol .
21062743	0	EDEM1	65,70	XTP3-B	74,80	EDEM1	XTP3-B	9695	27248	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps .
24200403	0	EDEM2	12,17	EDEM1	32,37	EDEM2	EDEM1	55741	9695	Gene	Gene	role|nmod|START_ENTITY compared|nsubj|role compared|nmod|END_ENTITY	The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol .
16431915	0	EDEM3	0,5	EDEM	17,21	EDEM3	EDEM	80267	9695	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	EDEM3 , a soluble EDEM homolog , enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming .
1752318	0	EDF	45,48	erythroid_differentiation_factor	11,43	EDF	erythroid differentiation factor	3624	3624	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of erythroid_differentiation_factor -LRB- EDF -RRB- on proliferation and differentiation of human hematopoietic progenitors .
11726541	0	EDG-1	0,5	Src	33,36	EDG-1	Src	1901	6714	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration .
8887679	0	EDG84A	18,24	FTZ-F1	33,39	EDG84A	FTZ-F1	40818(Tax:7227)	40045(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the EDG84A gene by FTZ-F1 during metamorphosis in Drosophila_melanogaster .
8125484	0	EDH17B2	126,133	17_beta-hydroxysteroid_dehydrogenase	81,117	EDH17B2	17 beta-hydroxysteroid dehydrogenase	3292	51478	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human familial and sporadic_breast_cancer : analysis of the coding regions of the 17_beta-hydroxysteroid_dehydrogenase 2 gene -LRB- EDH17B2 -RRB- using a single-strand conformation polymorphism assay .
8614400	0	EDH17B2	93,100	17_beta-hydroxysteroid_dehydrogenase_type_1	43,86	EDH17B2	17 beta-hydroxysteroid dehydrogenase type 1	3292	3292	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Coordination of transcription of the human 17_beta-hydroxysteroid_dehydrogenase_type_1 gene -LRB- EDH17B2 -RRB- by a cell-specific enhancer and a silencer : identification of a retinoic_acid response element .
16440132	0	EDM2	103,107	COL9A2	86,92	EDM2	COL9A2	1298	1298	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Intrafamilial phenotypic diversity in multiple epiphyseal_dysplasia associated with a COL9A2 mutation -LRB- EDM2 -RRB- .
10231870	0	EDN-3	56,61	endothelin-3	42,54	EDN-3	endothelin-3	1908	1908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A heterozygous frameshift mutation in the endothelin-3 -LRB- EDN-3 -RRB- gene in isolated Hirschsprung 's _ disease .
12193061	0	EDN1	156,160	endothelin-1	137,149	EDN1	endothelin-1	13614(Tax:10090)	13614(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin -2 gene -LRB- EDN2 -RRB- : comparison with the endothelin-1 gene -LRB- EDN1 -RRB- .
16521405	0	EDN1	54,58	endothelin-1	40,52	EDN1	endothelin-1	1906	1906	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	-LSB- Association of polymorphic variants in endothelin-1 -LRB- EDN1 -RRB- genes with the therapy of patients with cutaneous_T-cell_lymphomas -RSB- .
2018043	0	EDN1	85,89	endothelin-1	66,78	EDN1	endothelin-1	1906	1906	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal assignments of the human endothelin family genes : the endothelin-1 gene -LRB- EDN1 -RRB- to 6p23-p24 , the endothelin-2 gene -LRB- EDN2 -RRB- to 1p34 , and the endothelin-3 gene -LRB- EDN3 -RRB- to 20q13.2-q13 .3 .
8428511	0	EDN1	29,33	endothelin-1	10,22	EDN1	endothelin-1	1906	1906	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human endothelin-1 gene -LRB- EDN1 -RRB- encoding a peptide with potent vasoactive properties maps distal to HLA on chromosome arm 6p in close linkage to D6S89 .
10708518	0	EDN2	69,73	endothelin-2	50,62	EDN2	endothelin-2	1907	1907	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The prepro vasoactive intestinal contractor -LRB- VIC -RRB- / endothelin-2 gene -LRB- EDN2 -RRB- : structure , evolution , production , and embryonic expression .
2018043	0	EDN2	127,131	endothelin-2	108,120	EDN2	endothelin-2	1907	1907	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal assignments of the human endothelin family genes : the endothelin-1 gene -LRB- EDN1 -RRB- to 6p23-p24 , the endothelin-2 gene -LRB- EDN2 -RRB- to 1p34 , and the endothelin-3 gene -LRB- EDN3 -RRB- to 20q13.2-q13 .3 .
19527488	0	EDN3	31,35	endothelin-3	17,29	EDN3	endothelin-3	1908	1908	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Frequent loss of endothelin-3 -LRB- EDN3 -RRB- expression due to epigenetic inactivation in human breast_cancer .
2018043	0	EDN3	169,173	endothelin-3	150,162	EDN3	endothelin-3	1908	1908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal assignments of the human endothelin family genes : the endothelin-1 gene -LRB- EDN1 -RRB- to 6p23-p24 , the endothelin-2 gene -LRB- EDN2 -RRB- to 1p34 , and the endothelin-3 gene -LRB- EDN3 -RRB- to 20q13.2-q13 .3 .
22106312	0	EDNRA	52,57	endothelin_receptor_type_A	24,50	EDNRA	endothelin receptor type A	1909	1909	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common variant near the endothelin_receptor_type_A -LRB- EDNRA -RRB- gene is associated with intracranial_aneurysm risk .
24815860	0	EDNRA	70,75	endothelin_receptor_type_A	42,68	EDNRA	endothelin receptor type A	1909	1909	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The evaluation of endothelin_1 -LRB- EDN1 -RRB- and endothelin_receptor_type_A -LRB- EDNRA -RRB- gene polymorphisms in Hashimoto 's _ thyroiditis .
24398995	0	EDNRB	76,81	COL6A3	68,74	EDNRB	COL6A3	408082(Tax:9031)	396548(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
22897442	0	EDNRB	58,63	ET-3	53,57	EDNRB	ET-3	13618(Tax:10090)	13616(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Apolipoprotein_B is a new target of the GDNF/RET and ET-3 / EDNRB signalling pathways .
24398995	0	EDNRB	76,81	IGF2R	55,60	EDNRB	IGF2R	408082(Tax:9031)	395817(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	EDNRB	76,81	KLF6	83,87	EDNRB	KLF6	408082(Tax:9031)	420463(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	EDNRB	76,81	RGS2	62,66	EDNRB	RGS2	408082(Tax:9031)	378912(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
17618893	0	EDNRB	41,46	endothelin-beta_receptor	15,39	EDNRB	endothelin-beta receptor	1910	1910	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of endothelin-beta_receptor -LRB- EDNRB -RRB- gene variants in anorectal_malformations .
26166030	0	EDNRB	41,46	endothelin_receptor_B	18,39	EDNRB	endothelin receptor B	1910	1910	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Low expression of endothelin_receptor_B -LRB- EDNRB -RRB- is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid_cystic_carcinoma .
27039359	0	EDNRB	41,46	endothelin_receptor_type_B	13,39	EDNRB	endothelin receptor type B	100033875(Tax:9796)	100033875(Tax:9796)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	New test for endothelin_receptor_type_B -LRB- EDNRB -RRB- mutation genotyping in horses .
24398995	0	EDNRB	76,81	folr1	48,53	EDNRB	folr1	408082(Tax:9031)	395638(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24331460	0	EDS1	44,48	SAG101	76,82	EDS1	SAG101	823964(Tax:3702)	831345(Tax:3702)	Gene	Gene	complexes|compound|START_ENTITY complexes|nmod|END_ENTITY	Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity .
16428301	0	EDTP	15,19	egg-derived_tyrosine_phosphatase	24,56	EDTP	egg-derived tyrosine phosphatase	36959(Tax:7227)	36959(Tax:7227)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of EDTP , an egg-derived_tyrosine_phosphatase , in the early development of Drosophila_melanogaster .
11870209	0	EEA1	38,42	Rab22	17,22	EEA1	Rab22	8411	57403	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking .
10491193	0	EEA1	22,26	Rab5b	32,37	EEA1	Rab5b	8411	5869	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of EEA1 with Rab5b .
16138080	0	EEA1	19,23	p38	27,30	EEA1	p38	8411	1432	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Phosphorylation of EEA1 by p38 MAP kinase regulates mu_opioid_receptor endocytosis .
21556036	0	EEA1	31,35	p97	4,7	EEA1	p97	8411	4241	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	The p97 ATPase associates with EEA1 to regulate the size of early endosomes .
25854689	0	EEF1A1	57,63	eukaryotic_elongation_factor_1_alpha_1	17,55	EEF1A1	eukaryotic elongation factor 1 alpha 1	1915	1915	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of eukaryotic_elongation_factor_1_alpha_1 -LRB- EEF1A1 -RRB- in avian_reovirus sigma-C-induced apoptosis and inhibition of viral growth .
24285179	0	EEF1A2	0,6	p53	19,22	EEF1A2	p53	1917	7157	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular_carcinoma .
25394965	0	EEF1A2	1,7	p53	21,24	EEF1A2	p53	1917	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|compound|END_ENTITY	-LSB- EEF1A2 inhibits the p53 function in hepatocellular_carcinoma via PI3K/AKT/mTOR-dependent stabilization of MDM4 -RSB- .
9568107	0	EF-1_delta	41,51	elongation_factor-1_delta	14,39	EF-1 delta	elongation factor-1 delta	1936	1936	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of elongation_factor-1_delta -LRB- EF-1_delta -RRB- expression by oncogenes in human epithelial cells .
9988688	0	EF-1alpha	81,90	valyl-tRNA_synthetase	36,57	EF-1alpha	valyl-tRNA synthetase	1917	7407	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of mammalian valyl-tRNA_synthetase with elongation factor EF-1alpha in the complex with EF-1H .
14668475	0	EFA6	0,4	ARF6	26,30	EFA6	EFA6	5662	5662	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	EFA6 , exchange factor for ARF6 , regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement .
15540117	0	EFA6	56,60	ARF6	92,96	EFA6	ARF6	486859(Tax:9615)	490679(Tax:9615)	Gene	Gene	channel|nmod|START_ENTITY interaction|nmod|channel interaction|appos|factor factor|nmod|END_ENTITY	ARF6-dependent interaction of the TWIK1 K + channel with EFA6 , a GDP/GTP exchange factor for ARF6 .
16707115	0	EFA6	102,106	ARF6	86,90	EFA6	ARF6	73728(Tax:10090)	11845(Tax:10090)	Gene	Gene	family|compound|START_ENTITY expression|nmod|family expression|appos|factor factor|nmod|END_ENTITY	Distinct spatiotemporal expression of EFA6D , a guanine_nucleotide exchange factor for ARF6 , among the EFA6 family in mouse brain .
25114232	0	EFA6	0,4	Arf1	14,18	EFA6	Arf1	5662	375	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	EFA6 controls Arf1 and Arf6 activation through a negative feedback loop .
16413280	0	EFA6	12,16	Arf6	38,42	EFA6	Arf6	5662	382	Gene	Gene	role|nmod|START_ENTITY role|appos|factor factor|nmod|END_ENTITY	The role of EFA6 , exchange factor for Arf6 , for tight junction assembly , functions , and interaction with the actin cytoskeleton .
23603394	0	EFA6	0,4	Arf6	15,19	EFA6	Arf6	5662	382	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis .
16413273	0	EFA6A	20,25	ADP-ribosylation_factor_6	68,93	EFA6A	ADP-ribosylation factor 6	5662	382	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Functional assay of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 -LRB- ARF6 -RRB- , in dendritic formation of hippocampal neurons .
16413273	0	EFA6A	20,25	ARF6	95,99	EFA6A	ARF6	5662	382	Gene	Gene	assay|nmod|START_ENTITY assay|appos|END_ENTITY	Functional assay of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 -LRB- ARF6 -RRB- , in dendritic formation of hippocampal neurons .
18708035	0	EFA6A	28,33	ARF6	76,80	EFA6A	ARF6	73728(Tax:10090)	11845(Tax:10090)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Predominant localization of EFA6A , a guanine_nucleotide exchange factor for ARF6 , at the perisynaptic photoreceptor processes .
24261326	0	EFA6A	0,5	Arf6	48,52	EFA6A	Arf6	73728(Tax:10090)	11845(Tax:10090)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	EFA6A , a guanine_nucleotide exchange factor for Arf6 , interacts with sorting_nexin-1 and regulates neurite outgrowth .
17298598	0	EFA6A	32,37	alpha-actinin	141,154	EFA6A	alpha-actinin	5662	87	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Somatodendritic localization of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 , and its possible interaction with alpha-actinin in dendritic spines .
16707115	0	EFA6D	38,43	ARF6	86,90	EFA6D	ARF6	234353(Tax:10090)	11845(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|factor factor|nmod|END_ENTITY	Distinct spatiotemporal expression of EFA6D , a guanine_nucleotide exchange factor for ARF6 , among the EFA6 family in mouse brain .
25296758	0	EFA6R	16,21	ADP-ribosylation_Factor_6	139,164	EFA6R	ADP-ribosylation Factor 6	23362	382	Gene	Gene	START_ENTITY|nmod|Activation Activation|nmod|END_ENTITY	Exchange Factor EFA6R Requires C-terminal Targeting to the Plasma Membrane to Promote Cytoskeletal Rearrangement through the Activation of ADP-ribosylation_Factor_6 -LRB- ARF6 -RRB- .
25987128	0	EFEMP1	0,6	AEG-1	87,92	EFEMP1	AEG-1	2202	92140	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-kB signaling pathway .
14578376	0	EFEMP1	77,83	FBLN3	70,75	EFEMP1	FBLN3	2202	2202	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation and expression of the dominant drusen gene FBLN3 -LRB- EFEMP1 -RRB- in mammalian retina .
22919265	0	EFEMP2	81,87	PITX2	99,104	EFEMP2	PITX2	30008	5308	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Yeast two-hybrid analysis of a human trabecular meshwork cDNA library identified EFEMP2 as a novel PITX2 interacting protein .
23065816	0	EFNA1	40,45	miR-200c	15,23	EFNA1	miR-200c	1942	406985	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	G-A variant in miR-200c binding site of EFNA1 alters susceptibility to gastric_cancer .
24917152	0	EFhd2	24,29	Cdk5	0,4	EFhd2	Cdk5	27984(Tax:10090)	12568(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cdk5 phosphorylation of EFhd2 at S74 affects its calcium binding activity .
17683928	0	EG-VEGF	91,98	endocrine_gland-derived_vascular_endothelial_growth_factor	31,89	EG-VEGF	endocrine gland-derived vascular endothelial growth factor	84432	84432	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of endocrine_gland-derived_vascular_endothelial_growth_factor -LRB- EG-VEGF -RRB- in human pancreas and pancreatic_adenocarcinoma .
9477945	0	EGF	128,131	C1r	97,100	EGF	C1r	1950	715	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Solution structure of the epidermal_growth_factor -LRB- EGF -RRB- - like module of human complement protease C1r , an atypical member of the EGF family .
6287655	0	EGF	149,152	EGF_receptor	74,86	EGF	EGF receptor	1950	1956	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Genetics of receptors for bioactive polypeptides : expression of the human EGF_receptor gene and internalization and processing of the receptor-bound EGF in human-mouse cell hybrids .
21998680	0	EGF	52,55	EGR1	64,68	EGF	EGR1	1950	1958	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Coordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability .
22593802	0	EGF	38,41	EGR1	30,34	EGF	EGR1	1950	1958	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate_Cancer Cells .
20807437	0	EGF	0,3	ERK	51,54	EGF	ERK	13645(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	EGF regulates survivin stability through the Raf-1 / ERK pathway in insulin-secreting pancreatic b-cells .
21220563	0	EGF	0,3	ERK	93,96	EGF	ERK	100008808(Tax:9986)	26413(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation .
9176139	0	EGF	21,24	ET-1	0,4	EGF	ET-1	100714471	100726197	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	ET-1 cooperates with EGF to induce mitogenesis via a PTX-sensitive pathway in airway_smooth_muscle_cells .
15373782	0	EGF	30,33	Epidermal_growth_factor	0,23	EGF	Epidermal growth factor	1950	1950	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epidermal_growth_factor gene -LRB- EGF -RRB- polymorphism and risk of melanocytic_neoplasia .
1910383	0	EGF	26,29	Epidermal_growth_factor	1,24	EGF	Epidermal growth factor	1950	1950	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	-LSB- Epidermal_growth_factor -LRB- EGF -RRB- receptors in squamous_cell_carcinoma of the head_and_neck region -RSB- .
2559767	0	EGF	81,84	IGF-I	45,50	EGF	IGF-I	1950	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	-LSB- Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- and epidermal_growth_factor -LRB- EGF -RRB- receptors in primary non-glial human brain_tumors -RSB- .
20472833	0	EGF	20,23	MMP-9	33,38	EGF	MMP-9	1950	4318	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth .
6972865	0	EGF	112,115	NGF	78,81	EGF	NGF	13645(Tax:10090)	18049(Tax:10090)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	Effect of thyroxine , testosterone , and corticosterone on nerve_growth_factor -LRB- NGF -RRB- and epidermal_growth_factor -LRB- EGF -RRB- concentrations in adult female mouse submaxillary gland : dissociation of NGF and EGF responses .
20807437	0	EGF	0,3	Raf-1	45,50	EGF	Raf-1	13645(Tax:10090)	110157(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	EGF regulates survivin stability through the Raf-1 / ERK pathway in insulin-secreting pancreatic b-cells .
9950769	0	EGF	0,3	STAT2	37,42	EGF	STAT2	25313(Tax:10116)	288774(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells .
23532252	0	EGF	32,35	Src	14,17	EGF	Src	1950	6714	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	PTPa-mediated Src activation by EGF in human breast_cancer cells .
12520078	0	EGF	0,3	TGF-alpha	136,145	EGF	TGF-alpha	13645(Tax:10090)	21802(Tax:10090)	Gene	Gene	influence|nsubj|START_ENTITY influence|parataxis|+ +|dobj|mice mice|amod|END_ENTITY	EGF and TGF-alpha expression influence the developmental toxicity of TCDD : dose response and AhR phenotype in EGF , TGF-alpha , and EGF + TGF-alpha knockout mice .
12520078	0	EGF	110,113	TGF-alpha	136,145	EGF	TGF-alpha	13645(Tax:10090)	21802(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY +|nsubj|response +|dobj|mice mice|amod|END_ENTITY	EGF and TGF-alpha expression influence the developmental toxicity of TCDD : dose response and AhR phenotype in EGF , TGF-alpha , and EGF + TGF-alpha knockout mice .
16411340	0	EGF	41,44	TGF-alpha	30,39	EGF	TGF-alpha	25313(Tax:10116)	24827(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	-LSB- Enhanced expression of EGFR , TGF-alpha , EGF in hyperplastic_parathyroid glands in established stage of renal_failure in rats -RSB- .
8263129	0	EGF	163,166	TGF-alpha	168,177	EGF	TGF-alpha	1950	7039	Gene	Gene	epidermal_growth_factor|appos|START_ENTITY epidermal_growth_factor|dep|receptor receptor|amod|END_ENTITY	Androgens regulate proliferation of human_prostate_cancer cells in culture by increasing transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- and epidermal_growth_factor -LRB- EGF -RRB- / TGF-alpha receptor .
8617990	0	EGF	130,133	TGF-alpha	82,91	EGF	TGF-alpha	1950	7039	Gene	Gene	transforming_growth_factor-alpha|appos|START_ENTITY transforming_growth_factor-alpha|appos|END_ENTITY	Enhanced modulation of keratinocyte motility by transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- relative to epidermal_growth_factor -LRB- EGF -RRB- .
8772518	0	EGF	9,12	TGF-alpha	42,51	EGF	TGF-alpha	1950	7039	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Salivary EGF regulates eosinophil-derived TGF-alpha expression in hamster oral wounds .
1928747	0	EGF	47,50	TGF_alpha	104,113	EGF	TGF alpha	13645(Tax:10090)	21802(Tax:10090)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|receptor receptor|appos|END_ENTITY	Immunolocalization of epidermal_growth_factor -LRB- EGF -RRB- , EGF receptor and transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- during murine palatogenesis in vivo and in vitro .
1928747	0	EGF	53,56	TGF_alpha	104,113	EGF	TGF alpha	13645(Tax:10090)	21802(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Immunolocalization of epidermal_growth_factor -LRB- EGF -RRB- , EGF receptor and transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- during murine palatogenesis in vivo and in vitro .
7829602	0	EGF	70,73	TGF_alpha	110,119	EGF	TGF alpha	1950	7039	Gene	Gene	acid|appos|START_ENTITY acid|appos|transforming_growth_factor-alpha transforming_growth_factor-alpha|appos|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
7829602	0	EGF	70,73	TGF_alpha	179,188	EGF	TGF alpha	1950	7039	Gene	Gene	acid|appos|START_ENTITY Expression|nmod|acid Expression|dep|role role|nmod|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
9787404	0	EGF	58,61	TGF_alpha	63,72	EGF	TGF alpha	1950	7039	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
9787404	0	EGF	58,61	TGF_beta_1	74,84	EGF	TGF beta 1	1950	7040	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
9491776	0	EGF	112,115	TGFalpha	137,145	EGF	TGFalpha	1950	7039	Gene	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	Response to transforming_growth_factor_alpha -LRB- TGFalpha -RRB- and epidermal_growth_factor -LRB- EGF -RRB- in hepatocytes : lower EGF receptor affinity of TGFalpha is associated with more sustained activation of p42/p44 mitogen-activated_protein kinase and greater efficacy in stimulation of DNA synthesis .
21653632	0	EGF	121,124	TRPM6	47,52	EGF	TRPM6	25313(Tax:10116)	293874(Tax:10116)	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment .
19221002	0	EGF	135,138	activator_protein_1	104,123	EGF	activator protein 1	1950	2353	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator_protein_1 induced by EGF .
1714718	0	EGF	78,81	c-myc	50,55	EGF	c-myc	25313(Tax:10116)	24577(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Prostaglandins E2 and F2a mediate the increase in c-myc expression induced by EGF in primary rat hepatocyte cultures .
9264259	0	EGF	11,14	desmin	69,75	EGF	desmin	13645(Tax:10090)	13346(Tax:10090)	Gene	Gene	co-expressed|nsubjpass|START_ENTITY co-expressed|nmod|END_ENTITY	TGF-alpha , EGF , and their cognate EGF receptor are co-expressed with desmin during embryonic , fetal , and neonatal myogenesis in mouse tongue development .
7989108	0	EGF	178,181	epidermal-growth-factor	153,176	EGF	epidermal-growth-factor	1950	1950	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Presence of immunoassayable transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- in breast cyst fluid -LRB- BCF -RRB- : relationship with the intracystic electrolyte and epidermal-growth-factor -LRB- EGF -RRB- content .
10445389	0	EGF	38,41	epidermal_growth_factor	13,36	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of epidermal_growth_factor -LRB- EGF -RRB- on renal transport of PAH and amino_acids in amino_acid loaded rats .
10613783	0	EGF	36,39	epidermal_growth_factor	11,34	EGF	epidermal growth factor	100008808(Tax:9986)	100008808(Tax:9986)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor -LRB- EGF -RRB- on the development of EGF-receptor -LRB- EGF-R -RRB- binding in fetal rabbit lung organ culture .
11913544	0	EGF	36,39	epidermal_growth_factor	11,34	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor -LRB- EGF -RRB- on fetal islet B cells in vitro .
12012272	0	EGF	35,38	epidermal_growth_factor	10,33	EGF	epidermal growth factor	100008808(Tax:9986)	100008808(Tax:9986)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on steroid and cyclic nucleotide secretion , proliferation and ERK-related MAP-kinase in cultured rabbit granulosa cells .
15889422	0	EGF	45,48	epidermal_growth_factor	50,73	EGF	epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Role of thyroid hormone in the initiation of EGF -LRB- epidermal_growth_factor -RRB- expression in the sublingual gland of the postnatal mouse .
17629036	0	EGF	50,53	epidermal_growth_factor	25,48	EGF	epidermal growth factor	1950	1950	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of epidermal_growth_factor -LRB- EGF -RRB- expression in gastric_cancer .
17663016	0	EGF	125,128	epidermal_growth_factor	100,123	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Urine acidification has no effect on peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- signaling or epidermal_growth_factor -LRB- EGF -RRB- expression in rat urinary bladder urothelium .
18672282	0	EGF	45,48	epidermal_growth_factor	20,43	EGF	epidermal growth factor	1950	1950	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the epidermal_growth_factor -LRB- EGF -RRB- in the epididymis and accessory genital glands of the boar and functional effects on spermatozoa .
19166012	0	EGF	47,50	epidermal_growth_factor	22,45	EGF	epidermal growth factor	1950	1950	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of exogenous epidermal_growth_factor -LRB- EGF -RRB- on growth inhibition induced by aristolochic_acid_I -LRB- AA-I -RRB- in renal proximal tubular epithelial cells -RSB- .
1920276	0	EGF	36,39	epidermal_growth_factor	11,34	EGF	epidermal growth factor	1950	1950	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of epidermal_growth_factor -LRB- EGF -RRB- to a cultured human glioma cell line .
1928747	0	EGF	47,50	epidermal_growth_factor	22,45	EGF	epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of epidermal_growth_factor -LRB- EGF -RRB- , EGF receptor and transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- during murine palatogenesis in vivo and in vitro .
19336395	0	EGF	71,74	epidermal_growth_factor	46,69	EGF	epidermal growth factor	1950	1950	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The intracellular juxtamembrane domain of the epidermal_growth_factor _ -LRB- EGF -RRB- _ receptor is responsible for the allosteric regulation of EGF binding .
19853299	0	EGF	38,41	epidermal_growth_factor	13,36	EGF	epidermal growth factor	1950	1950	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	p53 Mediates epidermal_growth_factor -LRB- EGF -RRB- induction of MMP-2 transcription and trophoblast invasion .
1995079	0	EGF	35,38	epidermal_growth_factor	10,33	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on gluconeogenesis in isolated rat hepatocytes .
20203692	0	EGF	38,41	epidermal_growth_factor	13,36	EGF	epidermal growth factor	1950	1950	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	A functional epidermal_growth_factor -LRB- EGF -RRB- polymorphism , EGF serum levels and renal_cell_carcinoma risk in a Chinese population .
2049180	0	EGF	39,42	epidermal_growth_factor	14,37	EGF	epidermal growth factor	1950	1950	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	The action of epidermal_growth_factor -LRB- EGF -RRB- is limited to specific phases of the cell cycle in an EGF dependent colonic cell line .
2271554	0	EGF	60,63	epidermal_growth_factor	16,39	EGF	epidermal growth factor	1950	1950	Gene	Gene	receptor|compound|START_ENTITY site|nmod|receptor site|compound|END_ENTITY	Location of the epidermal_growth_factor binding site on the EGF receptor .
22931872	0	EGF	49,52	epidermal_growth_factor	24,47	EGF	epidermal growth factor	100008808(Tax:9986)	100008808(Tax:9986)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	-LSB- Therapeutic effects of epidermal_growth_factor -LRB- EGF -RRB- combined with plasma cryoprecipitate -LRB- CRYO -RRB- on the corneal_injury induced by paraquat -RSB- .
23270918	0	EGF	40,43	epidermal_growth_factor	15,38	EGF	epidermal growth factor	106502173	106502173	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of epidermal_growth_factor -LRB- EGF -RRB- on the in vitro development of isolated goat secondary follicles and the relative mRNA expression of EGF , EGF-R , FSH-R and P450 aromatase in cultured follicles .
2389590	0	EGF	43,46	epidermal_growth_factor	18,41	EGF	epidermal growth factor	1950	1950	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	-LSB- Determination of epidermal_growth_factor -LRB- EGF -RRB- receptors in basal_cell_carcinomas , squamous_cell_carcinomas and melanomas -RSB- .
2532289	0	EGF	61,64	epidermal_growth_factor	36,59	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	-LSB- Effect of experimental diabetes on epidermal_growth_factor -LRB- EGF -RRB- receptors in the rat liver -RSB- .
2602718	0	EGF	36,39	epidermal_growth_factor	11,34	EGF	epidermal growth factor	1950	1950	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of epidermal_growth_factor -LRB- EGF -RRB- on proliferation of the cells derived from the root resorbing tissue of human deciduous teeth -RSB- .
2784840	0	EGF	47,50	epidermal_growth_factor	22,45	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of uterine epidermal_growth_factor -LRB- EGF -RRB- receptors by estrogen in the mature rat and during the estrous cycle .
2957293	0	EGF	61,64	epidermal_growth_factor	36,59	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	-LSB- Effect of experimental diabetes on epidermal_growth_factor -LRB- EGF -RRB- receptors in the rat liver -RSB- .
3148118	0	EGF	35,38	epidermal_growth_factor	10,33	EGF	epidermal growth factor	1950	1950	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on a newly established head and neck squamous_carcinoma cell line .
315726	0	EGF	43,46	epidermal_growth_factor	18,41	EGF	epidermal growth factor	1950	1950	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of the epidermal_growth_factor -LRB- EGF -RRB- on the corneal epithelium in humans .
3489866	0	EGF	35,38	epidermal_growth_factor	10,33	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on experimental granulation tissue .
3490101	0	EGF	35,38	epidermal_growth_factor	10,33	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on blood flow and albumin extravasation in experimental granulation tissue .
3494514	0	EGF	45,48	epidermal_growth_factor	20,43	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	A trophic effect of epidermal_growth_factor -LRB- EGF -RRB- on rat colonic mucosa in organ culture .
3495790	0	EGF	35,38	epidermal_growth_factor	10,33	EGF	epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on -LSB- 3H -RSB- TdR incorporation into DNA in ad lib fed and fasted CD2F1 mice .
3498731	0	EGF	49,52	epidermal_growth_factor	24,47	EGF	epidermal growth factor	1950	1950	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Differential effects of epidermal_growth_factor -LRB- EGF -RRB- on cell locomotion and cell proliferation in a cloned human embryonal_carcinoma-derived cell line in vitro .
6126955	0	EGF	39,42	epidermal_growth_factor	14,37	EGF	epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of epidermal_growth_factor -LRB- EGF -RRB- on cell proliferation of the gastrointestinal_mucosa in rodents .
6131768	0	EGF	36,39	epidermal_growth_factor	11,34	EGF	epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor -LRB- EGF -RRB- on adult mouse small intestine in vivo and in organ culture .
7709468	0	EGF	50,53	epidermal_growth_factor	25,48	EGF	epidermal growth factor	1950	1950	Gene	Gene	correlation|appos|START_ENTITY correlation|nmod|END_ENTITY	-LSB- The correlation between epidermal_growth_factor -LRB- EGF -RRB- binding with receptors and the tyrosine phosphorylation of the EGF receptors in the plasma membrane and in the endosomes -RSB- .
7765094	0	EGF	100,103	epidermal_growth_factor	75,98	EGF	epidermal growth factor	1950	1950	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Proliferative response of fibroblasts expressing internalization-deficient epidermal_growth_factor -LRB- EGF -RRB- receptors is altered via differential EGF depletion effect .
7956924	0	EGF	134,137	epidermal_growth_factor	14,37	EGF	epidermal growth factor	1950	1950	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor -LRB- EGF -RRB- , its receptor , and related oncoprotein -LRB- erbB-2 -RRB- in human pituitary_tumors and response to EGF in vitro .
8031857	0	EGF	46,49	epidermal_growth_factor	21,44	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Short-term effect of epidermal_growth_factor -LRB- EGF -RRB- on sodium and glucose cotransport of isolated jejunal epithelial cells .
8258731	0	EGF	36,39	epidermal_growth_factor	11,34	EGF	epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of epidermal_growth_factor -LRB- EGF -RRB- on mouse sperm capacitation -RSB- .
8312873	0	EGF	51,54	epidermal_growth_factor	26,49	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Cytoprotective effects of epidermal_growth_factor -LRB- EGF -RRB- ointment containing nafamostat , a protease inhibitor , on tissue damage at burn sites in rats .
8369756	0	EGF	45,48	epidermal_growth_factor	20,43	EGF	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Systemic effects of epidermal_growth_factor -LRB- EGF -RRB- ointment containing protease inhibitor or gelatin in rats with burns or open_wounds .
8925996	0	EGF	43,46	epidermal_growth_factor	18,41	EGF	epidermal growth factor	1950	1950	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	-LSB- Concentration of epidermal_growth_factor -LRB- EGF -RRB- in serum of women with endometrial_cancer -RSB- .
9787980	0	EGF	33,36	epidermal_growth_factor	8,31	EGF	epidermal growth factor	1950	1950	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of epidermal_growth_factor -LRB- EGF -RRB- in oesophageal mucosal integrity .
9787404	0	EGF	58,61	glucocorticoid_receptor	19,42	EGF	glucocorticoid receptor	1950	2908	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
15976008	0	EGF	139,142	signal_transducer_and_activator_of_transcription_5	69,119	EGF	signal transducer and activator of transcription 5	1950	6776	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Estrogen negatively regulates epidermal growth factor -LRB- EGF -RRB- - mediated signal_transducer_and_activator_of_transcription_5 signaling in human EGF family receptor-overexpressing breast_cancer cells .
15976008	0	EGF	55,58	signal_transducer_and_activator_of_transcription_5	69,119	EGF	signal transducer and activator of transcription 5	1950	6776	Gene	Gene	factor|appos|START_ENTITY factor|dep|END_ENTITY	Estrogen negatively regulates epidermal growth factor -LRB- EGF -RRB- - mediated signal_transducer_and_activator_of_transcription_5 signaling in human EGF family receptor-overexpressing breast_cancer cells .
1974080	0	EGF	55,58	somatostatin	13,25	EGF	somatostatin	1950	6750	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of somatostatin and epidermal_growth_factor -LRB- EGF -RRB- on the proliferation of thyroid follicular cells in organ culture .
2894712	0	EGF	55,58	somatostatin	13,25	EGF	somatostatin	25313(Tax:10116)	24797(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of somatostatin and epidermal_growth_factor -LRB- EGF -RRB- on the proliferation of follicular cells in the organ-cultured rat thyroid .
17873319	0	EGF-R	83,88	VEGF-R	139,145	EGF-R	VEGF-R	1956	3791	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Differential effects of cetuximab and AEE_788 on epidermal_growth_factor_receptor -LRB- EGF-R -RRB- and vascular_endothelial_growth_factor_receptor -LRB- VEGF-R -RRB- in thyroid_cancer cell lines .
11999807	0	EGF-R	70,75	epidermal_growth_factor_receptor	36,68	EGF-R	epidermal growth factor receptor	1956	1956	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- in normal and diseased newborn lung tissues .
2544220	0	EGF-R	48,53	epidermal_growth_factor_receptor	14,46	EGF-R	epidermal growth factor receptor	1956	1956	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- in non-small_cell_lung_cancer .
3017396	0	EGF-R	48,53	epidermal_growth_factor_receptor	14,46	EGF-R	epidermal growth factor receptor	1956	1956	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- in human lung_tumours .
7507841	0	EGF-R	61,66	epidermal_growth_factor_receptor	27,59	EGF-R	epidermal growth factor receptor	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Differential expression of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus .
8291440	0	EGF-R	47,52	epidermal_growth_factor_receptor	13,45	EGF-R	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Heterologous epidermal_growth_factor_receptor -LRB- EGF-R -RRB- expression in larynx_cancer cell lines : evidence for the existence of structurally modified receptors .
23038672	0	EGF-factor_VIII	47,62	HC11	134,138	EGF-factor VIII	HC11	17304(Tax:10090)	15142(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Post-weaning increases in the milk-fat globule EGF-factor_VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells .
26009097	1	EGF-like_domain_7	12,29	Egfl7	31,36	EGF-like domain 7	Egfl7	51162	678640(Tax:7955)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of EGF-like_domain_7 -LRB- Egfl7 -RRB- in placental development and implantation .
16003946	0	EGF-r	70,75	TGF-alpha	115,124	EGF-r	TGF-alpha	1956	7039	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Immunohistochemical localization of epidermal_growth_factor_receptor -LRB- EGF-r -RRB- and transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- in developing human ovarian follicles .
12772780	0	EGF-receptor	14,26	ERRP	44,48	EGF-receptor	ERRP	24329(Tax:10116)	24329(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	Expression of EGF-receptor related protein -LRB- ERRP -RRB- decreases in gastric mucosa during aging and carcinogenesis .
16267402	0	EGF-receptor	148,160	heparin-binding_epidermal_growth_factor	90,129	EGF-receptor	heparin-binding epidermal growth factor	24329(Tax:10116)	25433(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Angiotensin_II promotes smooth muscle cell proliferation and migration through release of heparin-binding_epidermal_growth_factor and activation of EGF-receptor pathway .
10557079	0	EGF/TGFalpha	4,16	TGFalpha	45,53	EGF/TGFalpha	TGFalpha	1950;7039	7039	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|compound|END_ENTITY	The EGF/TGFalpha response element within the TGFalpha promoter consists of a multi-complex regulatory element .
20034472	0	EGFL7	77,82	miR-126	0,7	EGFL7	miR-126	678640(Tax:7955)	406913	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-126 inhibits non-small cell lung_cancer cells proliferation by targeting EGFL7 .
24888374	0	EGFR	0,4	ABCB1	121,126	EGFR	ABCB1	1956	5243	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|expression expression|nmod|END_ENTITY	EGFR mediates docetaxel resistance in human castration-resistant_prostate_cancer through the Akt-dependent expression of ABCB1 -LRB- MDR1 -RRB- .
23211830	0	EGFR	22,26	ADAM17	0,6	EGFR	ADAM17	13649(Tax:10090)	11491(Tax:10090)	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	ADAM17 transactivates EGFR signaling during embryonic eyelid closure .
22787409	0	EGFR	52,56	ALK	58,61	EGFR	ALK	1956	238	Gene	Gene	MET|compound|START_ENTITY MET|appos|END_ENTITY	Biomarkers that currently affect clinical practice : EGFR , ALK , MET , KRAS .
26373952	0	EGFR	29,33	ALK	47,50	EGFR	ALK	1956	238	Gene	Gene	PDGFRA|compound|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
23431153	0	EGFR	89,93	ANO1	35,39	EGFR	ANO1	1956	55107	Gene	Gene	signaling|nsubj|START_ENTITY activating|advcl|signaling promotes|advcl|activating promotes|nsubj|END_ENTITY	Calcium-activated chloride channel ANO1 promotes breast_cancer progression by activating EGFR and CAMK signaling .
25823819	0	EGFR	20,24	ANO1	0,4	EGFR	ANO1	1956	55107	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ANO1 interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head_and_neck_cancer .
19318561	0	EGFR	27,31	Androgen_receptor	0,17	EGFR	Androgen receptor	1956	367	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Androgen_receptor controls EGFR and ERBB2 gene expression at different levels in prostate_cancer cell lines .
26487496	0	EGFR	71,75	Androgen_receptor	0,17	EGFR	Androgen receptor	1956	367	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Androgen_receptor promotes tamoxifen agonist activity by activation of EGFR in ERa-positive breast_cancer .
23792445	0	EGFR	28,32	Annexin_A2	0,10	EGFR	Annexin A2	1956	302	Gene	Gene	START_ENTITY|nsubj|delays delays|amod|END_ENTITY	Annexin_A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation .
25479544	0	EGFR	4,8	BCRP	27,31	EGFR	BCRP	1956	9429	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	The EGFR Pathway Regulates BCRP Expression in NSCLC Cells : Role of Erlotinib .
25330173	0	EGFR	42,46	BMP	0,3	EGFR	BMP	1956	649	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	BMP Signaling in Astrocytes Downregulates EGFR to Modulate Survival and Maturation .
22281684	0	EGFR	90,94	BRAF	36,40	EGFR	BRAF	1956	673	Gene	Gene	activation|nmod|START_ENTITY inhibition|nmod|activation inhibition|nsubj|Unresponsiveness Unresponsiveness|nmod|colon_cancer colon_cancer|nmod|END_ENTITY	Unresponsiveness of colon_cancer to BRAF -LRB- V600E -RRB- inhibition through feedback activation of EGFR .
22773810	0	EGFR	41,45	BRAF	77,81	EGFR	BRAF	1956	673	Gene	Gene	inhibitors|amod|START_ENTITY resistance|nmod|inhibitors Lung_cancers|nmod|resistance harbor|nsubj|Lung_cancers harbor|dobj|mutations mutations|amod|END_ENTITY	Lung_cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS , NRAS , or MEK1 .
23224067	0	EGFR	26,30	BRAF	20,24	EGFR	BRAF	1956	673	Gene	Gene	associated|nsubjpass|START_ENTITY associated|advcl|affecting affecting|dobj|END_ENTITY	Mutations affecting BRAF , EGFR , PIK3CA , and KRAS are not associated with sporadic vestibular_schwannomas .
24594201	0	EGFR	20,24	BRAF	32,36	EGFR	BRAF	1956	673	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
25153497	0	EGFR	49,53	BRAF	69,73	EGFR	BRAF	1956	673	Gene	Gene	Genes|compound|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
25243790	0	EGFR	22,26	BRAF	53,57	EGFR	BRAF	1956	673	Gene	Gene	Changes|nmod|START_ENTITY Have|nsubj|Changes Have|dobj|Role Role|nmod|Cutaneous_Melanomas Cutaneous_Melanomas|compound|END_ENTITY	Epigenetic Changes of EGFR Have an Important Role in BRAF Inhibitor-Resistant Cutaneous_Melanomas .
25556681	0	EGFR	108,112	BRAF	66,70	EGFR	BRAF	1956	673	Gene	Gene	mutation|amod|START_ENTITY lung_adenocarcinoma|nmod|mutation mutation|nmod|lung_adenocarcinoma mutation|compound|END_ENTITY	Tumour-to-tumour metastasis from papillary_thyroid_carcinoma with BRAF mutation to lung_adenocarcinoma with EGFR mutation : the utility of mutation-specific antibodies .
25749811	0	EGFR	33,37	BRAF	104,108	EGFR	BRAF	1956	673	Gene	Gene	Activation|compound|START_ENTITY Cells|nmod|Activation Sensitivity|nmod|Cells Influenced|nsubj|Sensitivity Influenced|nmod|END_ENTITY	Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations .
26341080	0	EGFR	38,42	BRAF	20,24	EGFR	BRAF	1956	673	Gene	Gene	Number|appos|START_ENTITY Number|compound|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26373952	0	EGFR	29,33	BRAF	41,45	EGFR	BRAF	1956	673	Gene	Gene	PDGFRA|compound|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26842788	0	EGFR	69,73	BRAF	81,85	EGFR	BRAF	1956	673	Gene	Gene	PIK3CA|compound|START_ENTITY PIK3CA|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
20551433	0	EGFR	96,100	Bap170	0,6	EGFR	Bap170	37455(Tax:7227)	35560(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Bap170 , a subunit of the Drosophila PBAP chromatin remodeling complex , negatively regulates the EGFR signaling .
19360319	0	EGFR	126,130	Bax	37,40	EGFR	Bax	1956	581	Gene	Gene	gene|amod|START_ENTITY deletion|nmod|gene bearing|dobj|deletion non-small_cell_lung_cancer|acl|bearing sample|nmod|non-small_cell_lung_cancer Bcl-2|nmod|sample Expression|appos|Bcl-2 Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
18983466	0	EGFR	18,22	C-KIT	38,43	EGFR	C-KIT	1956	3815	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary_gland_carcinomas .
9583684	0	EGFR	96,100	C15	16,19	EGFR	C15	1956	51316	Gene	Gene	activation|nmod|START_ENTITY confers|dobj|activation confers|nsubj|protein protein|compound|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
26254615	0	EGFR	52,56	C23	31,34	EGFR	C23	1956	4691	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Involvement of nuclear protein C23 in activation of EGFR signaling in cervical_cancer .
26830684	0	EGFR	21,25	CD24	0,4	EGFR	CD24	1956	100133941	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric_cancer cells .
11893033	0	EGFR	21,25	CD44	0,4	EGFR	CD44	1956	960	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	CD44 associates with EGFR and erbB2 in metastasizing mammary_carcinoma cells .
18276068	0	EGFR	0,4	CD44	111,115	EGFR	CD44	1956	960	Gene	Gene	coupled|nsubjpass|START_ENTITY coupled|xcomp|CD44 CD44|dobj|effect effect|nmod|END_ENTITY	EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding , internalization and motogenic effect of CD44 .
18276068	0	EGFR	0,4	CD44	43,47	EGFR	CD44	1956	960	Gene	Gene	coupled|nsubjpass|START_ENTITY coupled|xcomp|END_ENTITY	EGFR and ErbB2 are functionally coupled to CD44 and regulate shedding , internalization and motogenic effect of CD44 .
22110198	0	EGFR	21,25	CD44	41,45	EGFR	CD44	1956	960	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast_cancer cells .
22110198	0	EGFR	79,83	CD44	41,45	EGFR	CD44	1956	960	Gene	Gene	activity|amod|START_ENTITY inhibition|nmod|activity suppresses|nmod|inhibition suppresses|dobj|expression expression|compound|END_ENTITY	Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast_cancer cells .
23265944	0	EGFR	20,24	CD44	0,4	EGFR	CD44	1956	960	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD44 interacts with EGFR and promotes head_and_neck_squamous_cell_carcinoma initiation and progression .
26757432	0	EGFR	42,46	CD44	30,34	EGFR	CD44	1956	960	Gene	Gene	phenotype|amod|START_ENTITY /|dobj|phenotype /|nsubj|relationship relationship|nmod|END_ENTITY	The relationship between EMT , CD44 -LRB- high -RRB- / EGFR -LRB- low -RRB- phenotype , and treatment response in head_and_neck_cancer cell lines .
22182753	0	EGFR	58,62	CD95	0,4	EGFR	CD95	1956	355	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	CD95 death receptor and epidermal_growth_factor_receptor -LRB- EGFR -RRB- in liver cell apoptosis and regeneration .
17940507	0	EGFR	48,52	CHK2	59,63	EGFR	CHK2	1956	11200	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	The predictive value of molecular markers -LRB- p53 , EGFR , ATM , CHK2 -RRB- in multimodally treated squamous_cell_carcinoma_of_the_oesophagus .
23893243	0	EGFR	46,50	CMTM7	20,25	EGFR	CMTM7	1956	112616	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	A novel 3p22 .3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth .
21398406	0	EGFR	55,59	CXCR7	38,43	EGFR	CXCR7	1956	57007	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate_cancer growth .
25168820	0	EGFR	44,48	CXCR7	23,28	EGFR	CXCR7	1956	57007	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The chemokine receptor CXCR7 interacts with EGFR to promote breast_cancer cell proliferation .
19483462	0	EGFR	21,25	Caveolin-1	0,10	EGFR	Caveolin-1	1956	857	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	Caveolin-1 regulates EGFR signaling in MCF-7_breast_cancer cells and enhances gefitinib-induced tumor cell inhibition .
15475003	0	EGFR	62,66	Cbl	22,25	EGFR	Cbl	1956	867	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Cbl with pTyr 1045 of the EGF_receptor -LRB- EGFR -RRB- is required to sort the EGFR to lysosomes for degradation .
12060562	0	EGFR	84,88	Clara_cell_secretory_protein	14,42	EGFR	Clara cell secretory protein	1956	7356	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	IL-13-induced Clara_cell_secretory_protein expression in airway epithelium : role of EGFR signaling pathway .
25061874	0	EGFR	0,4	DCBLD2	24,30	EGFR	DCBLD2	1956	131566	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis .
15461664	0	EGFR	21,25	DREF	0,4	EGFR	DREF	37455(Tax:7227)	34328(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	DREF is required for EGFR signalling during Drosophila wing vein development .
26918609	0	EGFR	39,43	Dsg2	47,51	EGFR	Dsg2	1956	1829	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	c-Src/Cav1-dependent activation of the EGFR by Dsg2 .
25973308	0	EGFR	31,35	Dynamin2	0,8	EGFR	Dynamin2	1956	1785	Gene	Gene	START_ENTITY|nsubj|delays delays|amod|END_ENTITY	Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular_carcinoma .
15492792	0	EGFR	37,41	EGFR	74,78	EGFR	EGFR	1956	1956	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Small_cell_lung_cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- .
15492792	0	EGFR	74,78	EGFR	37,41	EGFR	EGFR	1956	1956	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Small_cell_lung_cancer cells express EGFR and tyrosine phosphorylation of EGFR is inhibited by gefitinib -LRB- `` Iressa '' , ZD1839 -RRB- .
17626639	0	EGFR	16,20	EGFR	48,52	EGFR	EGFR	1956	1956	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung_cancer patients .
17626639	0	EGFR	48,52	EGFR	16,20	EGFR	EGFR	1956	1956	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung_cancer patients .
21352589	0	EGFR	24,28	EGFR	59,63	EGFR	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	The association between EGFR variant III , HPV , p16 , c-MET , EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous_cell_carcinoma of the head_and_neck .
21352589	0	EGFR	59,63	EGFR	24,28	EGFR	EGFR	1956	1956	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	The association between EGFR variant III , HPV , p16 , c-MET , EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous_cell_carcinoma of the head_and_neck .
23411345	0	EGFR	19,23	EGFR	40,44	EGFR	EGFR	1956	1956	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Cross-talk between EGFR and T-cadherin : EGFR activation promotes T-cadherin localization to intercellular contacts .
23411345	0	EGFR	40,44	EGFR	19,23	EGFR	EGFR	1956	1956	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Cross-talk between EGFR and T-cadherin : EGFR activation promotes T-cadherin localization to intercellular contacts .
25995992	0	EGFR	22,26	EGFR	87,91	EGFR	EGFR	1956	1956	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|dep|focus focus|nmod|activators activators|nmod|END_ENTITY	Plakophilin-2 induced EGFR phosphorylation : a focus on the intracellular activators of EGFR .
25995992	0	EGFR	87,91	EGFR	22,26	EGFR	EGFR	1956	1956	Gene	Gene	activators|nmod|START_ENTITY focus|nmod|activators phosphorylation|dep|focus phosphorylation|compound|END_ENTITY	Plakophilin-2 induced EGFR phosphorylation : a focus on the intracellular activators of EGFR .
19414352	0	EGFR	0,4	EGR1	27,31	EGFR	EGR1	1956	1958	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	EGFR mutation up-regulates EGR1 expression through the ERK pathway .
21822312	0	EGFR	25,29	EMT	49,52	EGFR	EMT	1956	3702	Gene	Gene	activity|amod|START_ENTITY activity|acl|induce induce|dobj|features features|compound|END_ENTITY	Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary_cancer cells .
26483386	0	EGFR	110,114	EMT	41,44	EGFR	EMT	1956	3702	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Carcinoma cells induce lumen filling and EMT in epithelial cells by soluble E-cadherin-mediated activation of EGFR .
26741322	0	EGFR	114,118	EMT	59,62	EGFR	EMT	13649(Tax:10090)	16428(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY downregulation|nmod|pathway macrophage|nmod|downregulation macrophage|dobj|END_ENTITY	Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung_cancer by downregulation of EGFR pathway .
26958807	0	EGFR	31,35	EMT	68,71	EGFR	EMT	1956	3702	Gene	Gene	pathway|amod|START_ENTITY activates|dobj|pathway activates|nmod|metastasis metastasis|nmod|END_ENTITY	Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid_cystic_carcinoma .
25963923	0	EGFR	91,95	EPHA2	29,34	EGFR	EPHA2	1956	1969	Gene	Gene	Inhibition|compound|START_ENTITY END_ENTITY|nmod|Inhibition	Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition .
26744526	0	EGFR	48,52	EPHA2	0,5	EGFR	EPHA2	1956	1969	Gene	Gene	Inhibitors|compound|START_ENTITY Acquired|nmod|Inhibitors Acquired|nsubj|Overcomes Overcomes|compound|END_ENTITY	EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung_Cancer .
26079946	0	EGFR	105,109	ER	165,167	EGFR	ER	1956	2099	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal_growth_factor_receptor -LRB- EGFR -RRB- by disrupting its interaction with estrogen_receptor -LRB- ER -RRB- .
19414352	0	EGFR	0,4	ERK	55,58	EGFR	ERK	1956	2048	Gene	Gene	up-regulates|amod|START_ENTITY EGR1|nsubj|up-regulates EGR1|nmod|pathway pathway|compound|END_ENTITY	EGFR mutation up-regulates EGR1 expression through the ERK pathway .
21989899	0	EGFR	14,18	ERK	41,44	EGFR	ERK	1956	5594	Gene	Gene	HER2|compound|START_ENTITY Expression|nmod|HER2 phosphorylated|nsubj|Expression phosphorylated|dobj|END_ENTITY	Expression of EGFR , HER2 , phosphorylated ERK and phosphorylated MEK in colonic_neoplasms of familial_adenomatous_polyposis patients .
22961667	0	EGFR	51,55	ERK	16,19	EGFR	ERK	1956	5594	Gene	Gene	inhibitors|amod|START_ENTITY causes|nmod|inhibitors causes|nsubj|Reactivation Reactivation|nmod|signaling signaling|compound|END_ENTITY	Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors .
23671927	0	EGFR	40,44	ERK	10,13	EGFR	ERK	1956	5594	Gene	Gene	therapies|amod|START_ENTITY corrected|nmod|therapies -LSB-|acl|corrected -LSB-|compound|END_ENTITY	Sustained ERK -LSB- corrected -RSB- inhibition by EGFR targeting therapies is a predictive factor for synergistic_cytotoxicity with PDT as neoadjuvant therapy .
24966948	0	EGFR	74,78	ERK	25,28	EGFR	ERK	1956	5594	Gene	Gene	Significance|nmod|START_ENTITY Significance|nmod|expression expression|compound|END_ENTITY	Significance of elevated ERK expression and its positive correlation with EGFR in Kazakh patients with esophageal_squamous_cell_carcinoma .
25246059	0	EGFR	121,125	ERK	92,95	EGFR	ERK	1956	5594	Gene	Gene	Pathway|compound|START_ENTITY Cells|nmod|Pathway Cells|nmod|Mediated Mediated|compound|END_ENTITY	Inhibitory Effects of Scutellarein on Proliferation of Human Lung Cancer A549 Cells through ERK and NFkB Mediated by the EGFR Pathway .
25953087	0	EGFR	72,76	ERK	117,120	EGFR	ERK	1956	5594	Gene	Gene	Epidermal_Growth_Factor_Receptor|appos|START_ENTITY Induce|dep|Epidermal_Growth_Factor_Receptor Induce|dep|Extracellular_Signal-regulated_Kinase Extracellular_Signal-regulated_Kinase|appos|END_ENTITY	Activating PIK3CA Mutations Induce an Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- / Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- Paracrine Signaling Axis in Basal-like Breast_Cancer .
18658095	0	EGFR	72,76	ERK1/2	0,6	EGFR	ERK1/2	1956	5595;5594	Gene	Gene	activation|compound|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	ERK1/2 mediate wounding - and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding .
24326851	0	EGFR	107,111	EWSR1	62,67	EGFR	EWSR1	1956	2130	Gene	Gene	rearrangement|nmod|START_ENTITY rearrangement|compound|END_ENTITY	A case of NUT midline carcinoma with no HPV_infection , slight EWSR1 rearrangement and strong expression of EGFR .
19464036	0	EGFR	68,72	Epidermal_Growth_Factor_Receptor	34,66	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- in canine mammary tissues .
20509969	0	EGFR	48,52	Epidermal_Growth_Factor_Receptor	14,46	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Assessment of Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- expression in human meningioma .
23608835	0	EGFR	64,68	Epidermal_Growth_Factor_Receptor	30,62	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	The Association Between Tumor Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutation and Multiple Primary Malignancies in Patients With Adenocarcinoma of the Lungs .
25495142	0	EGFR	117,121	Epidermal_Growth_Factor_Receptor	83,115	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	Sea-Urchin-Like Au Nanocluster with Surface-Enhanced Raman Scattering in Detecting Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutation Status of Malignant Pleural Effusion .
25897154	0	EGFR	53,57	Epidermal_Growth_Factor_Receptor	19,51	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Impact of Specific Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutations and Clinical Characteristics on Outcomes After Treatment With EGFR Tyrosine Kinase Inhibitors Versus Chemotherapy in EGFR-Mutant Lung Cancer : A Meta-Analysis .
26191356	0	EGFR	52,56	Epidermal_Growth_Factor_Receptor	18,50	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|nmod|END_ENTITY	Inhibitors of the Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- May Provide Effective Treatment for Lung_Adenocarcinoma .
26200642	0	EGFR	150,154	Epidermal_Growth_Factor_Receptor	116,148	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	Ultrasonography-Guided Core Biopsy of Supraclavicular Lymph Nodes for Diagnosis of Metastasis and Identification of Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutation in Advanced Lung_Cancer .
26396685	0	EGFR	103,107	Epidermal_Growth_Factor_Receptor	69,101	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Oxopyrido -LSB- 2,3-d -RSB- pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Inhibitors .
26443027	0	EGFR	111,115	Epidermal_Growth_Factor_Receptor	77,109	EGFR	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Design and Synthesis of Novel Schiff_base-benzothiazole hybrids as potential Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Inhibitors .
15540509	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene Bsr I polymorphism is associated with systemic_lupus_erythematosus .
15570078	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- status in primary colorectal_tumors does not correlate with EGFR expression in related metastatic sites : implications for treatment with EGFR-targeted monoclonal antibodies .
15980160	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- status in primary colorectal_tumors correlates with EGFR expression in related metastatic sites : biological and clinical implications .
16097449	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in childhood brain_tumors .
17516110	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression is associated with a worse prognosis in gastric_cancer patients undergoing curative surgery .
17595771	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation does not correlate with platinum resistance in ovarian_carcinoma .
18409189	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in prostatic_adenocarcinoma after hormonal therapy : a fluorescence in situ hybridization and immunohistochemical analysis .
19922469	0	EGFR	67,71	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	Epidermal_growth_factor_receptor in relation to tumor development : EGFR gene and cancer .
22668015	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression and mutations in the EGFR signaling pathway in correlation with anti-EGFR therapy in head_and_neck_squamous_cell_carcinomas .
25211582	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in lung_cancer : preclinical and clinical data .
25296354	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in lung_cancer : preclinical and clinical data .
26755002	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene amplification in high-grade gliomas : Western Indian tertiary cancer center experience .
27040854	0	EGFR	34,38	Epidermal_growth_factor_receptor	0,32	EGFR	Epidermal growth factor receptor	1956	1956	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in small_cell_lung_cancers : Two cases and a review of the literature .
17635524	0	EGFR	48,52	ErbB2	71,76	EGFR	ErbB2	1956	2064	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Assessment of epidermal_growth_factor_receptor -LRB- EGFR , ErbB1 -RRB- and HER2 -LRB- ErbB2 -RRB- protein expression levels and response to lapatinib -LRB- Tykerb , GW572016 -RRB- in an expanded panel of human normal and tumour cell lines .
17700572	0	EGFR	118,122	ErbB2	130,135	EGFR	ErbB2	1956	2064	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	NF-kappaB activation in inflammatory breast_cancer is associated with oestrogen_receptor downregulation , secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation .
17457047	0	EGFR	39,43	ErbB3	0,5	EGFR	ErbB3	1956	2065	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	ErbB3 expression and dimerization with EGFR influence pancreatic_cancer cell sensitivity to erlotinib .
18398842	0	EGFR	41,45	ErbB3	32,37	EGFR	ErbB3	1956	2065	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells .
20956544	0	EGFR	51,55	Erk	72,75	EGFR	Erk	1956	5594	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	ErbB2 stabilizes epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression via Erk and Sprouty2 in extracellular matrix-detached cells .
26936397	0	EGFR	15,19	Ezrin	0,5	EGFR	Ezrin	1956	7430	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small_Cell_Lung_Cancer Cells .
26721396	0	EGFR	0,4	FAM129B	20,27	EGFR	FAM129B	1956	64855	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	EGFR phosphorylates FAM129B to promote Ras activation .
12974390	0	EGFR	0,4	FRS2	32,36	EGFR	FRS2	1956	10818	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2 .
25151576	0	EGFR	68,72	FTS	0,3	EGFR	FTS	1956	64400	Gene	Gene	phosphorylation|nmod|START_ENTITY responsible|nmod|phosphorylation responsible|nsubj|END_ENTITY	FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells .
22634180	0	EGFR	84,88	Fn14	23,27	EGFR	Fn14	1956	51330	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|nmod|END_ENTITY	Elevated expression of Fn14 in non-small_cell_lung_cancer correlates with activated EGFR and promotes tumor cell migration and invasion .
21738726	0	EGFR	30,34	GPR54	0,5	EGFR	GPR54	1956	84634	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	GPR54 -LRB- KISS1R -RRB- transactivates EGFR to promote breast_cancer cell invasiveness .
25311788	0	EGFR	0,4	GPRC5A	55,61	EGFR	GPRC5A	13649(Tax:10090)	232431(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	EGFR phosphorylates and inhibits lung_tumor suppressor GPRC5A in lung_cancer .
25744720	0	EGFR	35,39	GPRC5A	22,28	EGFR	GPRC5A	13649(Tax:10090)	232431(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Binds Binds|compound|END_ENTITY	Lung_Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling .
25744720	0	EGFR	35,39	GPRC5A	22,28	EGFR	GPRC5A	13649(Tax:10090)	232431(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Binds Binds|compound|END_ENTITY	Lung_Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling .
23127433	0	EGFR	10,14	Gurken	88,94	EGFR	Gurken	37455(Tax:7227)	34171(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY requires|nsubj|signaling requires|dobj|trafficking trafficking|amod|END_ENTITY	Efficient EGFR signaling and dorsal-ventral_axis patterning requires syntaxin dependent Gurken trafficking .
20208558	0	EGFR	14,18	HB-EGF	53,59	EGFR	HB-EGF	1956	1839	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of EGFR by proteasome inhibition requires HB-EGF in pancreatic_cancer cells .
11495584	0	EGFR	126,130	HER-2	176,181	EGFR	HER-2	1956	2064	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	6-Substituted-4 - -LRB- 3-bromophenylamino -RRB- quinazolines as putative irreversible inhibitors of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and human epidermal_growth_factor_receptor -LRB- HER-2 -RRB- tyrosine kinases with enhanced antitumor activity .
12502359	1	EGFR	232,236	HER-2	288,293	EGFR	HER-2	1956	2064	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	The design of an orally active , irreversible inhibitor of the tyrosine kinase activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and the human epidermal_growth_factor_receptor-2 -LRB- HER-2 -RRB- .
21293538	0	EGFR	66,70	HER1	60,64	EGFR	HER1	1956	1956	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Lapatinib in breast_cancer - the predictive significance of HER1 -LRB- EGFR -RRB- , HER2 , PTEN and PIK3CA genes and lapatinib plasma level assessment .
23027125	0	EGFR	16,20	HER2	0,4	EGFR	HER2	1956	2064	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling .
25109965	0	EGFR	68,72	HER3	28,32	EGFR	HER3	1956	2065	Gene	Gene	resistance|nmod|START_ENTITY END_ENTITY|nmod|resistance	A role for the pseudokinase HER3 in the acquired resistance against EGFR - and HER2-directed targeted therapy .
26381405	0	EGFR	33,37	Hepatocyte_Growth_Factor	91,115	EGFR	Hepatocyte Growth Factor	1956	3082	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Integrin a6b4 Promotes Autocrine EGFR Signaling to Stimulate Migration and Invasion toward Hepatocyte_Growth_Factor -LRB- HGF -RRB- .
22052230	0	EGFR	39,43	Hepatocyte_growth_factor	0,24	EGFR	Hepatocyte growth factor	1956	3082	Gene	Gene	lung_cancer|amod|START_ENTITY expression|nmod|lung_cancer expression|amod|END_ENTITY	Hepatocyte_growth_factor expression in EGFR mutant lung_cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort .
24841203	0	EGFR	112,116	IGF-1R	166,172	EGFR	IGF-1R	1956	3480	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	A novel glycoengineered bispecific antibody format for targeted inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- and insulin-like_growth_factor_receptor_type_I -LRB- IGF-1R -RRB- demonstrating unique molecular properties .
12479108	0	EGFR	84,88	IL-6R	90,95	EGFR	IL-6R	1956	3570	Gene	Gene	PCNA|compound|START_ENTITY PCNA|appos|END_ENTITY	-LSB- Relationship between recurrence and metastasis of gastric_cancer and expression of EGFR , IL-6R , PCNA , and DI -RSB- .
22266872	0	EGFR	22,26	IMP3	14,18	EGFR	IMP3	1956	55272	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Regulation of IMP3 by EGFR signaling and repression by ERb : implications for triple-negative breast_cancer .
17918184	0	EGFR	0,4	IRF-1	27,32	EGFR	IRF-1	1956	3659	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells .
17448024	0	EGFR	57,61	Id-1	27,31	EGFR	Id-1	1956	3397	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of Id-1 and its association with EGFR in renal_cell_cancer .
18534028	0	EGFR	20,24	Jab1	0,4	EGFR	Jab1	1956	10987	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Jab1 is a target of EGFR signaling in ERalpha-negative breast_cancer .
17534846	0	EGFR	116,120	KRAS	35,39	EGFR	KRAS	13649(Tax:10090)	16653(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY distribution|nmod|mutation adenomatous_hyperplasia|nmod|distribution representation|nmod|adenomatous_hyperplasia representation|nmod|mutation mutation|compound|END_ENTITY	Disproportionate representation of KRAS gene mutation in atypical adenomatous_hyperplasia , but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas .
17591931	0	EGFR	52,56	KRAS	82,86	EGFR	KRAS	1956	3845	Gene	Gene	mutation|amod|START_ENTITY correlates|nmod|mutation correlates|nmod|mutation mutation|compound|END_ENTITY	Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung_adenocarcinomas with bronchioloalveolar_features .
18619559	0	EGFR	35,39	KRAS	0,4	EGFR	KRAS	1956	3845	Gene	Gene	inhibitors|amod|START_ENTITY predict|nmod|inhibitors predict|nsubj|mutations mutations|compound|END_ENTITY	KRAS mutations predict response to EGFR inhibitors .
19378369	0	EGFR	75,79	KRAS	0,4	EGFR	KRAS	1956	3845	Gene	Gene	inhibitors|amod|START_ENTITY use|nmod|inhibitors mutation|nmod|use mutation|nsubj|END_ENTITY	KRAS mutation in metastatic colorectal_cancer and its impact on the use of EGFR inhibitors .
19596959	0	EGFR	13,17	KRAS	36,40	EGFR	KRAS	1956	3845	Gene	Gene	Dominance|nmod|START_ENTITY END_ENTITY|nsubj|Dominance	Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status .
19943202	0	EGFR	44,48	KRAS	12,16	EGFR	KRAS	1956	3845	Gene	Gene	inhibition|amod|START_ENTITY mutations|nmod|inhibition mutations|nsubj|role role|nmod|END_ENTITY	The role of KRAS mutations in resistance to EGFR inhibition in the treatment of cancer .
20034873	0	EGFR	20,24	KRAS	1,5	EGFR	KRAS	1956	3845	Gene	Gene	status|amod|START_ENTITY status|nmod|status END_ENTITY|dobj|status	-LSB- KRAS status versus EGFR status in lung_cancer therapy -RSB- .
20049837	0	EGFR	20,24	KRAS	75,79	EGFR	KRAS	1956	3845	Gene	Gene	value|nmod|START_ENTITY downstream|nsubj|value downstream|xcomp|signaling signaling|nmod|status status|compound|END_ENTITY	Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal_cancer .
20108024	0	EGFR	111,115	KRAS	40,44	EGFR	KRAS	1956	3845	Gene	Gene	mutation|amod|START_ENTITY contrasts|nmod|mutation driver|acl:relcl|contrasts significance|dep|driver significance|nmod|mutations mutations|compound|END_ENTITY	Biological and clinical significance of KRAS mutations in lung_cancer : an oncogenic driver that contrasts with EGFR mutation .
20381121	0	EGFR	0,4	KRAS	94,98	EGFR	KRAS	1956	3845	Gene	Gene	fluorescence|amod|START_ENTITY fluorescence|dep|incidence incidence|acl|coexisting coexisting|dobj|mutations mutations|compound|END_ENTITY	EGFR fluorescence in situ hybridization-positive lung_adenocarcinoma : incidence of coexisting KRAS and BRAF mutations .
20616015	0	EGFR	45,49	KRAS	69,73	EGFR	KRAS	1956	3845	Gene	Gene	antibodies|nmod|START_ENTITY eliminate|nsubj|antibodies eliminate|dobj|cells cells|amod|END_ENTITY	T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS - and BRAF-mutated colorectal_cancer cells .
20884623	0	EGFR	0,4	KRAS	107,111	EGFR	KRAS	1956	3845	Gene	Gene	fluorescence|amod|START_ENTITY predicts|nsubj|fluorescence predicts|nmod|patients patients|amod|cetuximab cetuximab|nmod|END_ENTITY	EGFR fluorescence in situ hybridization pattern of chromosome 7 disomy predicts resistance to cetuximab in KRAS wild-type metastatic colorectal_cancer patients .
21118963	0	EGFR	122,126	KRAS	70,74	EGFR	KRAS	1956	3845	Gene	Gene	therapy|amod|START_ENTITY resistant|nmod|therapy colorectal_cancer|acl:relcl|resistant mutated|dobj|colorectal_cancer END_ENTITY|acl|mutated	MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal_cancer that is resistant to EGFR monoclonal antibody therapy .
22082529	0	EGFR	69,73	KRAS	116,120	EGFR	KRAS	1956	3845	Gene	Gene	regulator|nmod|START_ENTITY Down-regulation|appos|regulator enhances|nsubj|Down-regulation enhances|nmod|inhibition inhibition|nmod|cells cells|compound|END_ENTITY	Down-regulation of mitogen-inducible_gene_6 , a negative regulator of EGFR , enhances resistance to MEK inhibition in KRAS mutant cancer cells .
22329297	0	EGFR	100,104	KRAS	13,17	EGFR	KRAS	1956	3845	Gene	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|role role|nmod|testing testing|compound|END_ENTITY	-LSB- The role of KRAS gene mutation testing in colorectal_cancer -- a predictive biomarker of response to EGFR inhibitors therapy -RSB- .
22491422	0	EGFR	21,25	KRAS	148,152	EGFR	KRAS	1956	3845	Gene	Gene	amphiregulin|amod|START_ENTITY Cross-suppression|nmod|amphiregulin contribute|nsubj|Cross-suppression contribute|xcomp|cetuximab cetuximab|nmod|cells cells|compound|END_ENTITY	Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells .
22496619	0	EGFR	23,27	KRAS	10,14	EGFR	KRAS	13649(Tax:10090)	16653(Tax:10090)	Gene	Gene	antibodies|compound|START_ENTITY efficiency|nmod:poss|antibodies impairs|dobj|efficiency impairs|nsubj|END_ENTITY	Oncogenic KRAS impairs EGFR antibodies ' efficiency by C/EBPb-dependent suppression of EGFR expression .
22496619	0	EGFR	86,90	KRAS	10,14	EGFR	KRAS	13649(Tax:10090)	16653(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY suppression|nmod|expression impairs|nmod|suppression impairs|nsubj|END_ENTITY	Oncogenic KRAS impairs EGFR antibodies ' efficiency by C/EBPb-dependent suppression of EGFR expression .
22706026	0	EGFR	89,93	KRAS	66,70	EGFR	KRAS	1956	3845	Gene	Gene	repression|amod|START_ENTITY tumors|nmod|repression END_ENTITY|dobj|tumors	Triepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression .
22770374	0	EGFR	124,128	KRAS	26,30	EGFR	KRAS	1956	3845	Gene	Gene	genotype|amod|START_ENTITY advanced|nmod|genotype advanced|nsubj|Impact Impact|nmod|END_ENTITY	Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small_cell_lung_cancer patients with an EGFR wild_type genotype .
22787409	0	EGFR	52,56	KRAS	68,72	EGFR	KRAS	1956	3845	Gene	Gene	MET|compound|START_ENTITY MET|dep|END_ENTITY	Biomarkers that currently affect clinical practice : EGFR , ALK , MET , KRAS .
23874486	0	EGFR	80,84	KRAS	49,53	EGFR	KRAS	1956	3845	Gene	Gene	therapy|amod|START_ENTITY benefit|nmod|therapy benefit|nsubj|patients patients|nmod|abundance abundance|nmod|mutation mutation|compound|END_ENTITY	Colorectal_cancer patients with low abundance of KRAS mutation may benefit from EGFR antibody therapy .
23930206	0	EGFR	0,4	KRAS	6,10	EGFR	KRAS	1956	3845	Gene	Gene	BRAF|compound|START_ENTITY BRAF|appos|END_ENTITY	EGFR , KRAS , BRAF , and HER-2 molecular status in brain metastases from 77 NSCLC patients .
24025416	0	EGFR	10,14	KRAS	56,60	EGFR	KRAS	1956	3845	Gene	Gene	mutation|compound|START_ENTITY detected|nsubjpass|mutation detected|nmod|colorectal_carcinoma colorectal_carcinoma|compound|END_ENTITY	The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal_carcinoma before exposure to EGFR monoclonal antibodies .
24025416	0	EGFR	111,115	KRAS	56,60	EGFR	KRAS	1956	3845	Gene	Gene	antibodies|amod|START_ENTITY detected|nmod|antibodies detected|nmod|colorectal_carcinoma colorectal_carcinoma|compound|END_ENTITY	The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal_carcinoma before exposure to EGFR monoclonal antibodies .
24122611	0	EGFR	0,4	KRAS	6,10	EGFR	KRAS	1956	3845	Gene	Gene	BRAF|compound|START_ENTITY BRAF|appos|END_ENTITY	EGFR , KRAS , BRAF , and PIK3CA characterization in squamous_cell_anal_cancer .
24139827	0	EGFR	88,92	KRAS	154,158	EGFR	KRAS	1956	3845	Gene	Gene	non-small-cell_lung_cancer|compound|START_ENTITY patients|nmod|non-small-cell_lung_cancer chemotherapy|nmod|patients outcome|nmod|chemotherapy segregated|nsubj|outcome segregated|nmod|status status|compound|END_ENTITY	Clinical outcome with platinum-based chemotherapy in patients with advanced nonsquamous EGFR wild-type non-small-cell_lung_cancer segregated according to KRAS mutation status .
24594201	0	EGFR	20,24	KRAS	26,30	EGFR	KRAS	1956	3845	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
24595598	0	EGFR	0,4	KRAS	93,97	EGFR	KRAS	1956	3845	Gene	Gene	gain|amod|START_ENTITY factors|nsubj|gain factors|nmod|patients patients|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal_cancer treated with cetuximab .
25153497	0	EGFR	49,53	KRAS	55,59	EGFR	KRAS	1956	3845	Gene	Gene	Genes|compound|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
25808440	0	EGFR	10,14	KRAS	73,77	EGFR	KRAS	1956	3845	Gene	Gene	START_ENTITY|nmod|status status|compound|END_ENTITY	Targeting EGFR in metastatic colorectal_cancer beyond the limitations of KRAS status : alternative biomarkers and therapeutic strategies .
25992771	0	EGFR	118,122	KRAS	74,78	EGFR	KRAS	1956	3845	Gene	Gene	blockade|compound|START_ENTITY resistant|nmod|blockade resistant|nsubj|efficacy efficacy|nmod|subsets subsets|nmod|lung_cancer lung_cancer|compound|END_ENTITY	Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung_cancer resistant to single EGFR blockade .
26341080	0	EGFR	38,42	KRAS	108,112	EGFR	KRAS	1956	3845	Gene	Gene	Number|appos|START_ENTITY Value|nmod|Number Value|nmod|Patients Patients|nmod|Chemotherapy Chemotherapy|compound|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26373952	0	EGFR	29,33	KRAS	35,39	EGFR	KRAS	1956	3845	Gene	Gene	PDGFRA|compound|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26448020	0	EGFR	21,25	KRAS	59,63	EGFR	KRAS	1956	3845	Gene	Gene	Status|compound|START_ENTITY Analysis|nmod|Status Analysis|nmod|Colorectal_Cancer Colorectal_Cancer|compound|END_ENTITY	Combined Analysis of EGFR and PTEN Status in Patients With KRAS Wild-Type Metastatic Colorectal_Cancer .
26668065	0	EGFR	26,30	KRAS	155,159	EGFR	KRAS	1956	3845	Gene	Gene	Inhibitor|compound|START_ENTITY Afatinib|appos|Inhibitor Shows|nsubj|Afatinib Shows|dobj|Activity Activity|nmod|Cells Cells|nmod|Independent Independent|nmod|Status Status|compound|END_ENTITY	Afatinib , an Irreversible EGFR Family Inhibitor , Shows Activity Toward Pancreatic_Cancer Cells , Alone and in Combination with Radiotherapy , Independent of KRAS Status .
26799287	0	EGFR	101,105	KRAS	16,20	EGFR	KRAS	1956	3845	Gene	Gene	NSCLC|compound|START_ENTITY mutations|nmod|NSCLC mutations|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of KRAS mutations and c. 2369C _ > _ T -LRB- p.T790M -RRB- EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC : a study on circulating tumor DNA .
26799287	0	EGFR	57,61	KRAS	16,20	EGFR	KRAS	1956	3845	Gene	Gene	mutations|dobj|START_ENTITY mutations|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of KRAS mutations and c. 2369C _ > _ T -LRB- p.T790M -RRB- EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC : a study on circulating tumor DNA .
26842788	0	EGFR	69,73	KRAS	75,79	EGFR	KRAS	1956	3845	Gene	Gene	PIK3CA|compound|START_ENTITY PIK3CA|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
11783104	0	EGFR	13,17	LMP1	51,55	EGFR	LMP1	1956	17494204	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Increase of EGFR expression by Epstein-Barr_virus LMP1 in nasopharyngeal_carcinoma cells -RSB- .
15177893	0	EGFR	147,151	LMP1	104,108	EGFR	LMP1	1956	9260	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Nuclear factor kappa B -LRB- NFkappaB -RRB- dependent modulation of Epstein-Barr_virus latent membrane protein 1 -LRB- LMP1 -RRB- in epidermal growth factor receptor -LRB- EGFR -RRB- promoter activity .
21307189	0	EGFR	34,38	LMP1	19,23	EGFR	LMP1	1956	9260	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Epstein-Barr_virus LMP1 activates EGFR , STAT3 , and ERK through effects on PKCdelta .
24499623	0	EGFR	81,85	LMP1	27,31	EGFR	LMP1	1956	9260	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Epstein-Barr_Virus encoded LMP1 regulates cyclin_D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells .
9583684	0	EGFR	96,100	LMP1	20,24	EGFR	LMP1	1956	9260	Gene	Gene	activation|nmod|START_ENTITY confers|dobj|activation confers|nsubj|protein protein|compound|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
25801120	0	EGFR	13,17	LRIG1	0,5	EGFR	LRIG1	1956	26018	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	LRIG1 , human EGFR inhibitor , reverses multidrug resistance through modulation of ABCB1 and ABCG2 .
26251290	0	EGFR	71,75	MEK	62,65	EGFR	MEK	1956	5609	Gene	Gene	INHIBITION|compound|START_ENTITY INHIBITION|compound|END_ENTITY	A MULTICENTER , OPEN-LABEL PHASE II CLINICAL TRIAL OF COMBINED MEK PLUS EGFR INHIBITION FOR CHEMOTHERAPY-REFRACTORY ADVANCED PANCREATIC ADENOCARCINOMA .
26314331	0	EGFR	37,41	MIF	0,3	EGFR	MIF	1956	4282	Gene	Gene	Inhibitor|nmod|START_ENTITY Inhibitor|nsubj|END_ENTITY	MIF Is an Extracellular Inhibitor of EGFR .
24425048	0	EGFR	76,80	MIG6	51,55	EGFR	MIG6	1956	54206	Gene	Gene	regulate|dobj|START_ENTITY targets|xcomp|regulate targets|dobj|END_ENTITY	microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma .
21440529	0	EGFR	41,45	MMP1	62,66	EGFR	MMP1	1956	4312	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	ERK/MAPK pathways play critical roles in EGFR ligands-induced MMP1 expression .
22457794	0	EGFR	101,105	MUC1	0,4	EGFR	MUC1	1956	4582	Gene	Gene	activation|amod|START_ENTITY facilitating|dobj|activation contributes|advcl|facilitating contributes|nsubj|END_ENTITY	MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation .
23686469	0	EGFR	10,14	MUC1	26,30	EGFR	MUC1	1956	4582	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nummod|END_ENTITY	Activated EGFR stimulates MUC1 expression in human uterine and pancreatic_cancer cell lines .
26645913	0	EGFR	122,126	MUC1	92,96	EGFR	MUC1	1956	4582	Gene	Gene	activation|amod|START_ENTITY stimulates|nmod|activation stimulates|dobj|phosphorylation phosphorylation|nmod|association association|nmod|tail tail|compound|END_ENTITY	Pseudomonas_aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation .
27092881	0	EGFR	16,20	MUC1	0,4	EGFR	MUC1	1956	4582	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	MUC1 stimulates EGFR expression and function in endometrial_cancer .
9930070	0	EGFR	76,80	MUC1	0,4	EGFR	MUC1	1956	4582	Gene	Gene	expression|compound|START_ENTITY independent|nmod|expression independent|nsubj|expression expression|compound|END_ENTITY	MUC1 -LRB- episialin -RRB- expression in non-small_cell_lung_cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients .
21289483	0	EGFR	78,82	MiR-145	0,7	EGFR	MiR-145	1956	406937	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-145 inhibits cell proliferation of human lung_adenocarcinoma by targeting EGFR and NUDT1 .
9583684	0	EGFR	96,100	NF-kappa_B	64,74	EGFR	NF-kappa B	1956	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
25623042	0	EGFR	13,17	NFATc1	0,6	EGFR	NFATc1	13649(Tax:10090)	18018(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal_Transdifferentiation_in_the_Pancreas .
19489104	0	EGFR	89,93	NG2	95,98	EGFR	NG2	1956	1464	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	Analysis of stem cell lineage progression in the neonatal subventricular zone identifies EGFR + / NG2 - cells as transit-amplifying precursors .
25582778	0	EGFR	0,4	Nrf2	39,43	EGFR	Nrf2	13649(Tax:10090)	18024(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	EGFR mediates astragaloside_IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages .
19165235	0	EGFR	56,60	P53	0,3	EGFR	P53	1956	7157	Gene	Gene	downstream|compound|START_ENTITY inhibition|nmod|downstream contribute|nmod|inhibition contribute|nsubj|expression expression|compound|END_ENTITY	P53 and PTEN expression contribute to the inhibition of EGFR downstream signaling pathway by cetuximab .
23755891	0	EGFR	115,119	P53	0,3	EGFR	P53	1956	7157	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY recycling|nmod|epidermal_growth_factor_receptor upregulate|dobj|recycling upregulate|nsubj|mutations mutations|nummod|END_ENTITY	P53 mutations in triple_negative_breast_cancer upregulate endosomal recycling of epidermal_growth_factor_receptor -LRB- EGFR -RRB- increasing its oncogenic potency .
20953304	0	EGFR	71,75	PAI-1	48,53	EGFR	PAI-1	1956	5054	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	TGF-b1-Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling .
24265642	0	EGFR	116,120	PAI-1	40,45	EGFR	PAI-1	1956	5054	Gene	Gene	Adenocarcinoma|compound|START_ENTITY Patients|nmod|Adenocarcinoma Prognosis|nmod|Patients Associated|nmod|Prognosis Associated|dep|END_ENTITY	Plasminogen_Activator_Inhibitor_Type_1 -LRB- PAI-1 -RRB- A15T Gene Polymorphism Is Associated with Prognosis in Patients with EGFR Mutation Positive Pulmonary Adenocarcinoma .
16284070	0	EGFR	56,60	PCNA	78,82	EGFR	PCNA	24329(Tax:10116)	25737(Tax:10116)	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Adenylate_cyclase_5 and KCa1 .1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle .
25009014	0	EGFR	52,56	PD-L1	15,20	EGFR	PD-L1	1956	29126	Gene	Gene	mutations|amod|START_ENTITY activating|dobj|mutations overexpression|acl|activating overexpression|compound|END_ENTITY	Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell_lung_cancer .
25592115	0	EGFR	71,75	PD-L1	5,10	EGFR	PD-L1	397070(Tax:9823)	574058(Tax:9823)	Gene	Gene	mutation|amod|START_ENTITY pathway|nmod|mutation pathway|compound|END_ENTITY	PD-1 / PD-L1 pathway in non-small-cell_lung_cancer and its relation with EGFR mutation .
25658629	0	EGFR	163,167	PD-L1	16,21	EGFR	PD-L1	1956	29126	Gene	Gene	Mutation|compound|START_ENTITY Mediates|nmod|Mutation Mediates|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC : Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation .
25658629	0	EGFR	25,29	PD-L1	16,21	EGFR	PD-L1	1956	29126	Gene	Gene	Activation|compound|START_ENTITY END_ENTITY|nmod|Activation	Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC : Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation .
25998384	0	EGFR	33,37	PD-L1	24,29	EGFR	PD-L1	1956	29126	Gene	Gene	NSCLC|compound|START_ENTITY END_ENTITY|nmod|NSCLC	EGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-kB .
26175921	0	EGFR	52,56	PD-L1	0,5	EGFR	PD-L1	1956	29126	Gene	Gene	inhibitors|amod|START_ENTITY response|nmod|inhibitors associated|nmod|response associated|nsubj|expression expression|compound|END_ENTITY	PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors .
26676749	0	EGFR	74,78	PD-L1	100,105	EGFR	PD-L1	1956	29126	Gene	Gene	downstream|nmod|START_ENTITY downstream|acl:relcl|induce induce|dobj|expression expression|compound|END_ENTITY	Identification of the cell-intrinsic and extrinsic pathways downstream of EGFR and IFNy that induce PD-L1 expression in head_and_neck_cancer .
26898608	0	EGFR	119,123	PD-L1	0,5	EGFR	PD-L1	1956	29126	Gene	Gene	inhibitors|amod|START_ENTITY treated|nmod|inhibitors non-small_cell_lung_cancer|acl|treated patients|nmod|non-small_cell_lung_cancer prognostic|nmod|patients prognostic|nsubj|lymphocytes lymphocytes|amod|END_ENTITY	PD-L1 on peripheral blood T lymphocytes is prognostic in patients with non-small_cell_lung_cancer -LRB- NSCLC -RRB- treated with EGFR inhibitors .
25153497	0	EGFR	49,53	PIK3CA	61,67	EGFR	PIK3CA	1956	5290	Gene	Gene	Genes|compound|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
26373952	0	EGFR	29,33	PIK3CA	52,58	EGFR	PIK3CA	1956	5290	Gene	Gene	PDGFRA|compound|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
23867504	0	EGFR	36,40	PRL-3	22,27	EGFR	PRL-3	1956	11156	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells .
18386291	0	EGFR	82,86	PTEN	15,19	EGFR	PTEN	1956	5728	Gene	Gene	inhibitors|amod|START_ENTITY alters|nmod|inhibitors alters|nsubj|Restoration Restoration|nmod|expression expression|compound|END_ENTITY	Restoration of PTEN expression alters the sensitivity of prostate_cancer cells to EGFR inhibitors .
18704985	0	EGFR	21,25	PTEN	52,56	EGFR	PTEN	1956	5728	Gene	Gene	losses|compound|START_ENTITY losses|nmod|END_ENTITY	Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma_tumors .
19657395	0	EGFR	31,35	PTEN	74,78	EGFR	PTEN	1956	5728	Gene	Gene	analysis|nmod|START_ENTITY identified|nsubj|analysis identified|dobj|END_ENTITY	Gene expression analysis of an EGFR indirectly related pathway identified PTEN and MMP9 as reliable diagnostic markers for human glial_tumor specimens .
19763916	0	EGFR	82,86	PTEN	14,18	EGFR	PTEN	1956	5728	Gene	Gene	expressing|dobj|START_ENTITY Evaluation|acl|expressing Evaluation|nmod|expressions expressions|compound|END_ENTITY	Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR .
20018398	0	EGFR	35,39	PTEN	0,4	EGFR	PTEN	1956	5728	Gene	Gene	KRAS|compound|START_ENTITY END_ENTITY|nmod|KRAS	PTEN mutations and relationship to EGFR , ERBB2 , KRAS , and TP53 mutations in non-small_cell_lung_cancers .
21952748	0	EGFR	0,4	PTEN	36,40	EGFR	PTEN	1956	5728	Gene	Gene	reduction|amod|START_ENTITY reduction|nmod|expression expression|compound|END_ENTITY	EGFR - and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial_cancer cells .
22240798	0	EGFR	41,45	PTEN	8,12	EGFR	PTEN	1956	5728	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Loss Loss|nmod|END_ENTITY	Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary_gland_cancer .
22414288	4	EGFR	503,507	PTEN	593,597	PTEN	PI3K	5728	5293	Gene	Gene	PTEN|compound|START_ENTITY expression|nmod|PTEN expression|nmod|expression expression|nmod|END_ENTITY	METHODS AND MATERIALS : MCF-7 cell lines with low expression of EGFR and wild-type PTEN and MDA-MB-468 cell lines with high expression of EGFR and mutant PTEN were used .
23261230	0	EGFR	93,97	PTEN	43,47	EGFR	PTEN	1956	5728	Gene	Gene	syndrome|dep|START_ENTITY syndrome|amod|END_ENTITY	Primary lung_adenocarcinoma occurring in a PTEN related syndrome -LRB- Cowden 's _ disease -RRB- : routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L .
24594201	0	EGFR	20,24	PTEN	38,42	EGFR	PTEN	1956	5728	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
25870120	0	EGFR	120,124	PTEN	82,86	EGFR	PTEN	1956	5728	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Basal_cell_carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR .
26341080	0	EGFR	38,42	PTEN	32,36	EGFR	PTEN	1956	5728	Gene	Gene	Number|appos|START_ENTITY Number|appos|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26869029	0	EGFR	15,19	PTEN	0,4	EGFR	PTEN	1956	5728	Gene	Gene	trafficking|amod|START_ENTITY modulates|dobj|trafficking modulates|nsubj|END_ENTITY	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7 .
25995992	0	EGFR	22,26	Plakophilin-2	0,13	EGFR	Plakophilin-2	1956	5318	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Plakophilin-2 induced EGFR phosphorylation : a focus on the intracellular activators of EGFR .
25995992	0	EGFR	87,91	Plakophilin-2	0,13	EGFR	Plakophilin-2	1956	5318	Gene	Gene	activators|nmod|START_ENTITY focus|nmod|activators phosphorylation|dep|focus phosphorylation|compound|END_ENTITY	Plakophilin-2 induced EGFR phosphorylation : a focus on the intracellular activators of EGFR .
23319880	0	EGFR	38,42	Pten	28,32	EGFR	Pten	1956	5728	Gene	Gene	Overexpression|compound|START_ENTITY Inactivation|nmod|Overexpression Inactivation|nmod|END_ENTITY	Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST .
22558469	0	EGFR	25,29	RAB-7	0,5	EGFR	RAB-7	1956	174834(Tax:6239)	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis_elegans .
22703031	0	EGFR	0,4	S1166	5,10	EGFR	S1166	1956	1077562(Tax:198215)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung_cancer cell growth .
24377927	0	EGFR	36,40	SARA	0,4	EGFR	SARA	1956	9372	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	SARA and RNF11 at the crossroads of EGFR signaling and trafficking .
23602371	0	EGFR	0,4	SGLT1	41,46	EGFR	SGLT1	1956	6523	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	EGFR cooperates with glucose transporter SGLT1 to enable chromatin remodeling in response to ionizing radiation .
23765757	0	EGFR	120,124	SGLT1	78,83	EGFR	SGLT1	1956	6523	Gene	Gene	inhibitors|amod|START_ENTITY sensitizes|nmod|inhibitors sensitizes|nsubj|inhibition inhibition|nmod|END_ENTITY	EGFR-SGLT1 interaction does not respond to EGFR modulators , but inhibition of SGLT1 sensitizes prostate_cancer cells to EGFR tyrosine kinase inhibitors .
11713584	0	EGFR	0,4	STAT1	44,49	EGFR	STAT1	1956	6772	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	EGFR dependent expression of STAT3 -LRB- but not STAT1 -RRB- in breast_cancer .
17918184	0	EGFR	0,4	STAT1	37,42	EGFR	STAT1	1956	6772	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|IRF-1 IRF-1|nmod|activation activation|compound|END_ENTITY	EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells .
22693070	0	EGFR	45,49	STAT1	0,5	EGFR	STAT1	1956	6772	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|expression expression|nummod|END_ENTITY	STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 .
26141950	0	EGFR	67,71	STAT1	0,5	EGFR	STAT1	1956	6772	Gene	Gene	Inhibition|compound|START_ENTITY Enhanced|nmod|Inhibition Enhanced|nsubjpass|Activation Activation|compound|END_ENTITY	STAT1 Activation Is Enhanced by Cisplatin and Variably Affected by EGFR Inhibition in HNSCC Cells .
11713584	0	EGFR	0,4	STAT3	29,34	EGFR	STAT3	1956	6774	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	EGFR dependent expression of STAT3 -LRB- but not STAT1 -RRB- in breast_cancer .
21856923	0	EGFR	15,19	STAT3	45,50	EGFR	STAT3	24329(Tax:10116)	25125(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	Transactivated EGFR mediates a - AR-induced STAT3 activation and cardiac_hypertrophy .
22693070	0	EGFR	45,49	STAT3	80,85	EGFR	STAT3	1956	6774	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nmod|END_ENTITY	STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 .
24135280	0	EGFR	0,4	STAT3/5	51,58	EGFR	STAT3/5	1956	6774;6776	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma .
15901674	0	EGFR	77,81	Scc1	63,67	EGFR	Scc1	1956	5795	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The C. _ elegans homolog of the mammalian tumor suppressor Dep-1 / Scc1 inhibits EGFR signaling to regulate binary cell fate decisions .
24619958	0	EGFR	90,94	Serine_protease_inhibitor_Kazal_type_1	0,38	EGFR	Serine protease inhibitor Kazal type 1	1956	6690	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Serine_protease_inhibitor_Kazal_type_1 promotes epithelial-mesenchymal transition through EGFR signaling pathway in prostate_cancer .
9030684	0	EGFR	104,108	Sos1	96,100	EGFR	Sos1	13649(Tax:10090)	20662(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Mutation in Sos1 dominantly enhances a weak allele of the EGFR , demonstrating a requirement for Sos1 in EGFR signaling and development .
26447186	0	EGFR	25,29	Sox2	63,67	EGFR	Sox2	1956	6657	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Galectin-3 modulates the EGFR signaling-mediated regulation of Sox2 expression via c-Myc in lung_cancer .
25623042	0	EGFR	13,17	Sox9	44,48	EGFR	Sox9	13649(Tax:10090)	20682(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Transcription Transcription|compound|END_ENTITY	NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal_Transdifferentiation_in_the_Pancreas .
17320394	0	EGFR	22,26	Sprouty2	40,48	EGFR	Sprouty2	1956	10253	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Spatial regulation of EGFR signaling by Sprouty2 .
26773066	0	EGFR	12,16	Src	6,9	EGFR	Src	24329(Tax:10116)	83805(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY regulates|nsubj|Signaling END_ENTITY|parataxis|regulates	Csk / Src / EGFR Signaling regulates migration of myofibroblasts and alveolarization .
15337524	0	EGFR	38,42	Syk	24,27	EGFR	Syk	1956	6850	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells .
12606576	0	EGFR	43,47	TACE	0,4	EGFR	TACE	13645(Tax:10090)	11491(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	TACE is required for the activation of the EGFR by TGF-alpha in tumors .
15592458	0	EGFR	23,27	TCPTP	120,125	EGFR	TCPTP	1956	5771	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP .
26832794	0	EGFR	0,4	TFAP2C	21,27	EGFR	TFAP2C	1956	7022	Gene	Gene	Regulated|nsubjpass|START_ENTITY Regulated|nmod|END_ENTITY	EGFR Is Regulated by TFAP2C in Luminal Breast_Cancer and Is a Target for Vandetanib .
24594844	0	EGFR	11,15	Tyrosine_Kinase	28,43	EGFR	Tyrosine Kinase	1956	7294	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Overcoming EGFR T790M-based Tyrosine_Kinase Inhibitor Resistance with an Allele-specific DNAzyme .
12063543	0	EGFR	0,4	VEGF	66,70	EGFR	VEGF	1956	7422	Gene	Gene	treatment|amod|START_ENTITY down-regulates|nsubj|treatment down-regulates|dobj|expression expression|compound|END_ENTITY	EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration .
16540671	0	EGFR	0,4	VEGF	41,45	EGFR	VEGF	1956	7422	Gene	Gene	tyrosine|nsubj|START_ENTITY tyrosine|ccomp|decrease decrease|dobj|expression expression|amod|END_ENTITY	EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 - independent and HIF-1-dependent mechanisms .
16760272	0	EGFR	58,62	VEGF	108,112	EGFR	VEGF	1956	7422	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Interaction between the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and the vascular_endothelial_growth_factor -LRB- VEGF -RRB- pathways : a rational approach for multi-target anticancer therapy .
17896140	0	EGFR	94,98	VEGF	50,54	EGFR	VEGF	1956	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and epidermal_growth_factor_receptor -LRB- EGFR -RRB- is an independent prognostic indicator of worse outcome in gastric_cancer patients .
19234131	0	EGFR	109,113	VEGF	36,40	EGFR	VEGF	1956	7422	Gene	Gene	containing|dobj|START_ENTITY END_ENTITY|xcomp|containing	Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR .
20141840	0	EGFR	41,45	VEGF	10,14	EGFR	VEGF	13649(Tax:10090)	22339(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY signaling|dobj|synergizes END_ENTITY|acl|signaling	Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development .
23913252	0	EGFR	107,111	VEGF	113,117	EGFR	VEGF	1956	7422	Gene	Gene	START_ENTITY|dep|CD34 CD34|compound|END_ENTITY	Prognostic significance of human_papillomavirus _ -LRB- HPV -RRB- status and expression of selected markers -LRB- HER2/neu , EGFR , VEGF , CD34 , p63 , p53 and Ki67/MIB -1 -RRB- on outcome after -LRB- chemo - -RRB- radiotherapy in patients with squamous_cell_carcinoma_of_uterine_cervix .
25272226	0	EGFR	70,74	VEGF	20,24	EGFR	VEGF	1956	7422	Gene	Gene	Line|compound|START_ENTITY Dependent|nmod|Line Dependent|nsubj|Potentiation Potentiation|nmod|Production Production|compound|END_ENTITY	EGF Potentiation of VEGF Production Is Cell Density Dependent in H292 EGFR Wild Type NSCLC Cell Line .
26478789	0	EGFR	94,98	VEGF	50,54	EGFR	VEGF	1956	7422	Gene	Gene	Vascular_Endothelial_Growth_Factor|appos|START_ENTITY Vascular_Endothelial_Growth_Factor|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- and Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- in Patients With Serous_Ovarian_Carcinoma and Their Clinical Significance .
17008069	0	EGFR	67,71	alpha-actinin	11,24	EGFR	alpha-actinin	37455(Tax:7227)	31166(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling .
21352589	0	EGFR	24,28	c-MET	52,57	EGFR	c-MET	1956	4233	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	The association between EGFR variant III , HPV , p16 , c-MET , EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous_cell_carcinoma of the head_and_neck .
26260789	0	EGFR	82,86	c-Met	89,94	EGFR	c-Met	1956	4233	Gene	Gene	Antibody|compound|START_ENTITY Antibody|compound|END_ENTITY	Impact of Cell-Surface_Antigen Expression on Target Engagement and Function of an EGFR x c-Met Bispecific Antibody .
26761634	0	EGFR	35,39	c-Met	42,47	EGFR	c-Met	13649(Tax:10090)	17295(Tax:10090)	Gene	Gene	antibody|compound|START_ENTITY antibody|amod|END_ENTITY	Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody .
12354693	0	EGFR	145,149	c-erbB-2	123,131	EGFR	c-erbB-2	1956	2064	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Induction of cancer cell migration by epidermal_growth_factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR .
9673387	0	EGFR	169,173	c-erbB-2	175,183	EGFR	c-erbB-2	1956	2064	Gene	Gene	oncoprotein|amod|START_ENTITY oncoprotein|amod|END_ENTITY	Matrix metalloproteinase expression in human breast_cancer : an immunohistochemical study including correlation with cathepsin_D , type IV collagen , laminin , fibronectin , EGFR , c-erbB-2 oncoprotein , p53 , steroid receptors status and proliferative indices .
18789131	0	EGFR	40,44	caveolin-1	18,28	EGFR	caveolin-1	1956	857	Gene	Gene	internalization|compound|START_ENTITY internalization|amod|END_ENTITY	Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK .
19446582	0	EGFR	87,91	caveolin-1	52,62	EGFR	caveolin-1	1956	857	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Growth suppression by ursodeoxycholic_acid involves caveolin-1 enhanced degradation of EGFR .
18776588	0	EGFR	73,77	cortactin	15,24	EGFR	cortactin	1956	2017	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Association of cortactin , fascin-1 and epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in ovarian_carcinomas : correlation with clinicopathological parameters .
26509856	0	EGFR	54,58	eGFR	27,31	EGFR	eGFR	1956	1956	Gene	Gene	FUNCTION|compound|START_ENTITY END_ENTITY|nmod|FUNCTION	COMBINING CREATININE-BASED eGFR WITH CYSTATIN_C-BASED EGFR TO BETTER ASSESS RENAL FUNCTION IN PATIENTS WITH DIABETES AND CHRONIC KIDNEY DISEASE 3A : IMPLICATIONS FOR DRUG SELECTION AND DOSAGE IN TYPE 2 DIABETES .
10411339	0	EGFR	73,77	epidermal_growth_factor_receptor	39,71	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Acquired rearrangement of an amplified epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in a human glioblastoma xenograft .
10463620	0	EGFR	76,80	epidermal_growth_factor_receptor	42,74	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Intragenic mutation analysis of the human epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in malignant human oral keratinocytes .
12008195	0	EGFR	88,92	epidermal_growth_factor_receptor	54,86	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Phase I and pharmacokinetic study of BIBX 1382 BS , an epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitor , given in a continuous daily oral administration .
15221011	0	EGFR	128,132	epidermal_growth_factor_receptor	25,57	EGFR	epidermal growth factor receptor	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	survival|nmod|START_ENTITY promotes|dobj|survival promotes|nsubj|END_ENTITY	The tumor-specific de2-7 epidermal_growth_factor_receptor -LRB- EGFR -RRB- promotes cells survival and heterodimerizes with the wild-type EGFR .
15644326	0	EGFR	61,65	epidermal_growth_factor_receptor	27,59	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Simultaneous inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- signaling and enhanced activation of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptor-mediated apoptosis induction by an scFv : sTRAIL fusion protein with specificity for human EGFR .
15718144	0	EGFR	46,50	epidermal_growth_factor_receptor	12,44	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Blockade of epidermal_growth_factor_receptor -LRB- EGFR -RRB- activity .
15829495	0	EGFR	90,94	epidermal_growth_factor_receptor	56,88	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of the dinucleotide repeat polymorphism in the epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in head_and_neck_cancer patients .
15967033	0	EGFR	55,59	epidermal_growth_factor_receptor	21,53	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	Prognostic impact of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression on loco-regional recurrence after preoperative radiotherapy in rectal_cancer .
16203806	0	EGFR	142,146	epidermal_growth_factor_receptor	87,119	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|dep|signaling	Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A '' - DTPA-hu3S193 by inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- signaling with EGFR tyrosine kinase inhibitor AG1478 .
16279103	0	EGFR	49,53	epidermal_growth_factor_receptor	15,47	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in ovarian_carcinoma stage III-IV -RSB- .
16311351	0	EGFR	61,65	epidermal_growth_factor_receptor	27,59	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Frequent overexpression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in mammary high grade ductal_carcinomas with myoepithelial differentiation .
16428503	0	EGFR	77,81	epidermal_growth_factor_receptor	43,75	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Novel toll-like_receptor_9 agonist induces epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibition and synergistic antitumor activity with EGFR inhibitors .
16637298	0	EGFR	27,31	epidermal_growth_factor_receptor	33,65	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	-LSB- Trophoblast expression of EGFR -LRB- epidermal_growth_factor_receptor -RRB- in the preeclampsia placenta -RSB- .
16919868	0	EGFR	59,63	epidermal_growth_factor_receptor	25,57	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutational status of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in thymomas_and_thymic_carcinomas .
17011067	0	EGFR	92,96	epidermal_growth_factor_receptor	58,90	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Clinicopathologic features and prognostic implications of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene copy number and protein expression in non-small_cell_lung_cancer .
17052260	0	EGFR	113,117	epidermal_growth_factor_receptor	79,111	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Clinical usefulness of serum telomerase reverse transcriptase -LRB- hTERT -RRB- mRNA and epidermal_growth_factor_receptor -LRB- EGFR -RRB- mRNA as a novel tumor marker for lung_cancer .
17192868	0	EGFR	47,51	epidermal_growth_factor_receptor	13,45	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene mutations on the expression of EGFR , phosphoryl-Akt , and phosphoryl-MAPK , and on the prognosis of patients with non-small_cell_lung_cancer .
17354229	0	EGFR	44,48	epidermal_growth_factor_receptor	10,42	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of epidermal_growth_factor_receptor -LRB- EGFR -RRB- kinase mutations , EGFR gene amplifications , and KRAS mutations on survival of pancreatic_adenocarcinoma .
17468034	0	EGFR	49,53	epidermal_growth_factor_receptor	15,47	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene copy number amplification with neck lymph node metastasis in areca-associated oral_carcinomas .
17609586	0	EGFR	117,121	epidermal_growth_factor_receptor	83,115	EGFR	epidermal growth factor receptor	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Combination treatment with ionising radiation and gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitor , significantly inhibits bladder_cancer cell growth in vitro and in vivo .
18519677	0	EGFR	85,89	epidermal_growth_factor_receptor	51,83	EGFR	epidermal growth factor receptor	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	RET/PTC-induced cell growth is mediated in part by epidermal_growth_factor_receptor -LRB- EGFR -RRB- activation : evidence for molecular and functional interactions between RET and EGFR .
19416119	0	EGFR	42,46	epidermal_growth_factor_receptor	8,40	EGFR	epidermal growth factor receptor	24329(Tax:10116)	24329(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in corneal_remodelling in diabetes .
19434314	0	EGFR	85,89	epidermal_growth_factor_receptor	51,83	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression and significance of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in breast_cancer .
19620791	0	EGFR	80,84	epidermal_growth_factor_receptor	46,78	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Small-molecule tyrosine kinase inhibitors of epidermal_growth_factor_receptor -LRB- EGFR -RRB- -RSB- .
20399639	0	EGFR	62,66	epidermal_growth_factor_receptor	28,60	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cytotoxic drugs up-regulate epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in colon_cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent_cell-mediated-cytotoxicity -LRB- ADCC -RRB- .
20446909	0	EGFR	26,30	epidermal_growth_factor_receptor	32,64	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Cardiovascular effects of EGFR -LRB- epidermal_growth_factor_receptor -RRB- monoclonal antibodies .
20532621	0	EGFR	64,68	epidermal_growth_factor_receptor	30,62	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Hypoxia-induced activation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- kinase in the cerebral cortex of newborn piglets : the role of nitric_oxide .
20579333	0	EGFR	68,72	epidermal_growth_factor_receptor	34,66	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in oral_squamous_cell_carcinoma in relation to proliferation , apoptosis , angiogenesis and lymphangiogenesis .
20956544	0	EGFR	51,55	epidermal_growth_factor_receptor	17,49	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	ErbB2 stabilizes epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression via Erk and Sprouty2 in extracellular matrix-detached cells .
21199607	0	EGFR	91,95	epidermal_growth_factor_receptor	35,67	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	variables|amod|START_ENTITY phosphorylated|dobj|variables phosphorylated|nsubj|Correlations Correlations|nmod|expression expression|nmod|END_ENTITY	Correlations between expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , phosphorylated EGFR , cyclooxygenase-2 and clinicopathological variables and treatment outcomes in nasopharyngeal_carcinomas .
21457545	0	EGFR	51,55	epidermal_growth_factor_receptor	17,49	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in the epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in triple negative breast_cancer : possible implications for targeted therapy .
21482992	0	EGFR	102,106	epidermal_growth_factor_receptor	68,100	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	American Society of Clinical Oncology provisional_clinical_opinion : epidermal_growth_factor_receptor -LRB- EGFR -RRB- Mutation testing for patients with advanced non-small-cell_lung_cancer considering first-line EGFR tyrosine kinase inhibitor therapy .
21512415	0	EGFR	65,69	epidermal_growth_factor_receptor	31,63	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Tyrosine kinase inhibitors and epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in non-small cell lung cancer : to test or not to test ?
21626329	0	EGFR	65,69	epidermal_growth_factor_receptor	31,63	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	The influence of intracellular epidermal_growth_factor_receptor -LRB- EGFR -RRB- signal activation on the outcome of EGFR tyrosine kinase inhibitor treatment for pulmonary_adenocarcinoma .
21789142	0	EGFR	55,59	epidermal_growth_factor_receptor	21,53	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The emerging role of epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitors in first-line treatment for patients with advanced non-small_cell_lung_cancer positive for EGFR mutations .
22003817	0	EGFR	112,116	epidermal_growth_factor_receptor	78,110	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	inhibitors|appos|START_ENTITY END_ENTITY|dobj|inhibitors	Design and synthesis of novel human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- / epidermal_growth_factor_receptor -LRB- EGFR -RRB- dual inhibitors bearing a pyrrolo -LSB- 3,2-d -RSB- pyrimidine scaffold .
22026926	0	EGFR	44,48	epidermal_growth_factor_receptor	10,42	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in European patients with advanced colorectal_cancer harbors infrequent mutations in its tyrosine kinase domain .
22085274	0	EGFR	49,53	epidermal_growth_factor_receptor	15,47	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Suppression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression by small hairpin RNA inhibits the growth of human nonsmall_cell_lung_cancers bearing wild-type and mutant EGFR .
22361824	0	EGFR	77,81	epidermal_growth_factor_receptor	43,75	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Semiology of skin_toxicity associated with epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitors .
23064060	0	EGFR	152,156	epidermal_growth_factor_receptor	119,151	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The pharmacokinetics and long-term therapeutic effects of gefitinib in patients with lung_adenocarcinoma harboring the epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation .
23327060	0	EGFR	46,50	epidermal_growth_factor_receptor	12,44	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Analysis of epidermal_growth_factor_receptor -LRB- EGFR -RRB- status in endometrial_stromal_sarcoma .
23910906	0	EGFR	136,140	epidermal_growth_factor_receptor	102,134	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A prospective , phase II , open-label study -LRB- JO22903 -RRB- of first-line erlotinib in Japanese patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation-positive advanced non-small-cell_lung_cancer -LRB- NSCLC -RRB- .
24344129	0	EGFR	105,109	epidermal_growth_factor_receptor	71,103	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	UBE4B protein couples ubiquitination and sorting machineries to enable epidermal_growth_factor_receptor -LRB- EGFR -RRB- degradation .
25259789	0	EGFR	65,69	epidermal_growth_factor_receptor	31,63	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Clinical significance of serum epidermal_growth_factor_receptor -LRB- EGFR -RRB- levels in patients with breast_cancer .
25417703	0	EGFR	54,58	epidermal_growth_factor_receptor	20,52	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	BRCA1 regulation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in human breast_cancer cells involves microRNA-146a and is critical for its tumor suppressor function .
2570489	0	EGFR	51,55	epidermal_growth_factor_receptor	17,49	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Amplification of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene and oncogenes in human gastric_carcinomas .
25991665	0	EGFR	58,62	epidermal_growth_factor_receptor	24,56	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in ameloblastomas .
26199571	0	EGFR	71,75	epidermal_growth_factor_receptor	37,69	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The prognostic significance of tumor epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression change after neoadjuvant chemoradiation in patients with rectal_adenocarcinoma .
26199571	0	EGFR	71,75	epidermal_growth_factor_receptor	37,69	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The prognostic significance of tumor epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression change after neoadjuvant chemoradiation in patients with rectal_adenocarcinoma .
26464643	0	EGFR	55,59	epidermal_growth_factor_receptor	21,53	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation and serum cyclooxygenase-2 Level , and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small_cell_lung_cancer cells .
26944829	0	EGFR	73,77	epidermal_growth_factor_receptor	39,71	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Inner nuclear membrane localization of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in spontaneous canine model of invasive micropapillary_carcinoma of the mammary gland .
7475300	0	EGFR	48,52	epidermal_growth_factor_receptor	14,46	EGFR	epidermal growth factor receptor	24329(Tax:10116)	24329(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression on in vivo growth of rat C6 glioma cells .
7949212	0	EGFR	48,52	epidermal_growth_factor_receptor	14,46	EGFR	epidermal growth factor receptor	404306(Tax:9615)	404306(Tax:9615)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in non-affected and tumorous mammary tissue of female dogs .
7970118	0	EGFR	63,67	epidermal_growth_factor_receptor	29,61	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in various types of renal_injury .
8142117	0	EGFR	58,62	epidermal_growth_factor_receptor	24,56	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The prognostic value of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in breast_cancer patients .
8513016	0	EGFR	86,90	epidermal_growth_factor_receptor	52,84	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Proto-oncogene of genomic DNA , related to the human epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene , from clinically normal domestic animals .
8758275	0	EGFR	49,53	epidermal_growth_factor_receptor	15,47	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in endometrioid_carcinoma_of_the_ovary -RSB- .
9475680	0	EGFR	79,83	epidermal_growth_factor_receptor	45,77	EGFR	epidermal growth factor receptor	1956	1956	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Altered mRNA expression pattern of placental epidermal_growth_factor_receptor -LRB- EGFR -RRB- in pregnancies complicated by preeclampsia and/or intrauterine_growth_retardation .
9703936	0	EGFR	64,68	epidermal_growth_factor_receptor_family_proteins	14,62	EGFR	epidermal growth factor receptor family proteins	1956	1956	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor_receptor_family_proteins -LRB- EGFR , c-erbB-2 and c-erbB-3 -RRB- in gastric_cancer and chronic_gastritis .
9930070	0	EGFR	76,80	episialin	6,15	EGFR	episialin	1956	4582	Gene	Gene	expression|compound|START_ENTITY independent|nmod|expression independent|nsubj|expression expression|compound|END_ENTITY	MUC1 -LRB- episialin -RRB- expression in non-small_cell_lung_cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients .
14703768	0	EGFR	46,50	epithelial_growth_factor_receptor	11,44	EGFR	epithelial growth factor receptor	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of epithelial_growth_factor_receptor -LRB- EGFR -RRB- kinase inhibitors on genetically reconstituted mouse mammary glands .
23046633	0	EGFR	53,57	epithelial_growth_factor_receptor	18,51	EGFR	epithelial growth factor receptor	1956	1956	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of epithelial_growth_factor_receptor -LRB- EGFR -RRB- predicts better response to neo-adjuvant chemotherapy in patients with triple-negative breast_cancer .
7532293	0	EGFR	54,58	eps8	18,22	EGFR	eps8	1956	2059	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine - and SH2-independent .
21439954	0	EGFR	43,47	erbB3	78,83	EGFR	erbB3	1956	2065	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|interacting interacting|nmod|END_ENTITY	Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines .
19692652	0	EGFR	47,51	hepatocyte_growth_factor	74,98	EGFR	hepatocyte growth factor	1956	3082	Gene	Gene	talk|nmod|START_ENTITY mediate|dobj|talk mediate|advcl|enhancing enhancing|dobj|production production|compound|END_ENTITY	MEK , p38 , and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte_growth_factor production from human mesenchymal stem cells .
20716641	0	EGFR	167,171	hepatocyte_growth_factor	44,68	EGFR	hepatocyte growth factor	1956	3082	Gene	Gene	mutation|amod|START_ENTITY induced|nmod|mutation resistance|acl|induced reverses|dobj|resistance reverses|nsubj|TAK-701 TAK-701|appos|antibody antibody|nmod|END_ENTITY	TAK-701 , a humanized monoclonal antibody to hepatocyte_growth_factor , reverses gefitinib resistance induced by tumor-derived HGF in non-small_cell_lung_cancer with an EGFR mutation .
23402326	0	EGFR	53,57	integrin_beta1	15,29	EGFR	integrin beta1	1956	3688	Gene	Gene	resistance|compound|START_ENTITY Association|nmod|resistance Association|nmod|END_ENTITY	Association of integrin_beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small_cell_lung_cancer .
21932060	0	EGFR	83,87	interleukin-8	54,67	EGFR	interleukin-8	1956	3576	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells .
26514923	0	EGFR	72,76	matrix_metalloproteinase-9	16,42	EGFR	matrix metalloproteinase-9	13649(Tax:10090)	4318	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cadmium induces matrix_metalloproteinase-9 expression via ROS-dependent EGFR , NF - B , and AP-1 pathways in human endothelial cells .
24012640	0	EGFR	21,25	miR-21	14,20	EGFR	miR-21	1956	406991	Gene	Gene	loop|compound|START_ENTITY loop|amod|END_ENTITY	Blockage of a miR-21 / EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas .
25561284	0	EGFR	24,28	miR-491	49,56	EGFR	miR-491	1956	574444	Gene	Gene	START_ENTITY|nmod|Activity Activity|amod|END_ENTITY	Ginsenoside_Rh2 Targets EGFR by Up-Regulation of miR-491 to Enhance Anti-tumor Activity in Hepatitis_B_Virus-Related Hepatocellular_Carcinoma .
22450744	0	EGFR	72,76	p14	0,3	EGFR	p14	1956	11102	Gene	Gene	mutation|compound|START_ENTITY harbouring|dobj|mutation cells|acl|harbouring growth|nmod|cells inhibits|dobj|growth inhibits|nsubj|END_ENTITY	p14 -LRB- ARF -RRB- inhibits the growth of lung_adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway .
24169260	0	EGFR	58,62	p14	35,38	EGFR	p14	1956	11102	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Mutation of TP53 and alteration of p14 -LRB- arf -RRB- expression in EGFR - and KRAS-mutated lung_adenocarcinomas .
26545468	0	EGFR	105,109	p14	60,63	EGFR	p14	1956	11102	Gene	Gene	DNA|nmod|START_ENTITY combining|nmod|DNA combining|dobj|END_ENTITY	Improved therapeutic effectiveness by combining recombinant p14 -LRB- ARF -RRB- with antisense complementary DNA of EGFR in laryngeal_squamous_cell_carcinoma .
26585064	0	EGFR	114,118	p14ARF	71,77	EGFR	p14ARF	1956	1029	Gene	Gene	DNA|nmod|START_ENTITY combining|nmod|DNA combining|dobj|END_ENTITY	WITHDRAWN : Improved therapeutic effectiveness by combining recombinant p14ARF with antisense complementary DNA of EGFR in laryngeal_squamous_cell_carcinoma .
15473298	0	EGFR	77,81	p15	39,42	EGFR	p15	1956	1030	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	-LSB- Association of homozygous deletion of p15 and p16 gene and amplification of EGFR gene in laryngeal_squamous_cell_carcinoma -RSB- .
21352589	0	EGFR	24,28	p16	47,50	EGFR	p16	1956	1029	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	The association between EGFR variant III , HPV , p16 , c-MET , EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous_cell_carcinoma of the head_and_neck .
24021343	0	EGFR	15,19	p16INK4A	0,8	EGFR	p16INK4A	1956	1029	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	p16INK4A , p53 , EGFR expression and KRAS mutation status in squamous_cell_cancers of the anus : correlation with outcomes following chemo-radiotherapy .
10764044	0	EGFR	74,78	p53	33,36	EGFR	p53	1956	7157	Gene	Gene	distinguish|amod|START_ENTITY pathway|nmod|distinguish suppressor|dobj|pathway suppressor|nsubj|inactivation inactivation|nmod|tumor tumor|compound|END_ENTITY	Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult_astrocytomas .
10870681	0	EGFR	114,118	p53	165,168	EGFR	p53	1956	7157	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY expression|appos|epidermal_growth_factor_receptor analysis|nmod|expression oncogene|nsubj|analysis oncogene|iobj|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
16986486	0	EGFR	76,80	p53	71,74	EGFR	p53	1956	7157	Gene	Gene	ret-oncogene|dep|START_ENTITY ret-oncogene|compound|END_ENTITY	-LSB- Prognostic value of the expression of thyreoglobulin and oncomarkers -LRB- p53 , EGFR , ret-oncogene -RRB- in different types of papillary_carcinoma_of_the_thyroid : clinicomorphological and immunohistochemical studies -RSB- .
19360319	0	EGFR	126,130	p53	32,35	EGFR	p53	1956	7157	Gene	Gene	gene|amod|START_ENTITY deletion|nmod|gene bearing|dobj|deletion non-small_cell_lung_cancer|acl|bearing sample|nmod|non-small_cell_lung_cancer Bcl-2|nmod|sample Expression|appos|Bcl-2 Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
21290211	0	EGFR	72,76	p53	78,81	EGFR	p53	1956	7157	Gene	Gene	mutations|amod|START_ENTITY mutations|amod|END_ENTITY	Establishment and characterization of six human lung_cancer cell lines : EGFR , p53 gene mutations and expressions of drug sensitivity genes .
21388911	0	EGFR	34,38	p53	66,69	EGFR	p53	1956	7157	Gene	Gene	Epidermal_growth_factor_receptor|appos|START_ENTITY abundance|nsubj|Epidermal_growth_factor_receptor abundance|dobj|correlates correlates|nmod|accumulation accumulation|compound|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- abundance correlates with p53 and Bcl-2 accumulation and patient age in a small cohort of North African nasopharyngeal_carcinoma patients .
22068033	0	EGFR	37,41	p53	0,3	EGFR	p53	1956	7157	Gene	Gene	inhibitors|amod|START_ENTITY acquired|nmod|inhibitors acquired|nsubj|modulates modulates|compound|END_ENTITY	p53 modulates acquired resistance to EGFR inhibitors and radiation .
22286119	4	EGFR	886,890	p53	881,884	CK20	CK7	54474	3855	Gene	Gene	CDX2|dep|START_ENTITY CDX2|dep|END_ENTITY	METHODS AND RESULTS : We immunohistochemically examined the CK7/CK20 patterns , mucin expression profiles -LRB- MUC5AC , MUC6 , MUC2 and CD10 -RRB- , and the cancer-related molecules -LRB- CDX2 , p53 , EGFR and b-catenin -RRB- , using a tissue microarray with 870 GCs .
23872073	0	EGFR	53,57	p53	70,73	EGFR	p53	1956	7157	Gene	Gene	species|amod|START_ENTITY species|compound|END_ENTITY	Induction of renal fibrotic genes by TGF-b1 requires EGFR activation , p53 and reactive oxygen species .
24021343	0	EGFR	15,19	p53	10,13	EGFR	p53	1956	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	p16INK4A , p53 , EGFR expression and KRAS mutation status in squamous_cell_cancers of the anus : correlation with outcomes following chemo-radiotherapy .
24927258	0	EGFR	153,157	p53	120,123	EGFR	p53	1956	7157	Gene	Gene	blockade|amod|START_ENTITY functional|nmod|blockade functional|dobj|deficiency deficiency|compound|END_ENTITY	Increased growth-inhibitory and cytotoxic activity of arsenic_trioxide in head_and_neck_carcinoma cells with functional p53 deficiency and resistance to EGFR blockade .
25623760	0	EGFR	67,71	p53	29,32	EGFR	p53	1956	7157	Gene	Gene	gefitinib|amod|START_ENTITY Effect|nmod|gefitinib Effect|nmod|adenovirus adenovirus|compound|END_ENTITY	-LSB- Effect of recombinant human p53 adenovirus -LRB- Ad-p53 -RRB- combined with EGFR inhibitor gefitinib on the sensitivity of breast_cancer MDA-MB-468 cells -RSB- .
9417299	0	EGFR	44,48	p53	39,42	EGFR	p53	1956	7157	Gene	Gene	START_ENTITY|nsubj|proliferation proliferation|appos|expression expression|nmod|END_ENTITY	-LSB- Cellular proliferation , expression of p53 , EGFR and apoptosis index of healthy mucosa of the bladder with TCC ; pre - and post-intravesical BCG immunohistochemical study -RSB- .
9664135	0	EGFR	17,21	p53	69,72	EGFR	p53	1956	7157	Gene	Gene	levels|amod|START_ENTITY levels|nmod|restoration restoration|nmod|END_ENTITY	Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head_and_neck_squamous_cell_carcinoma cell line .
16015604	0	EGFR	83,87	phosphoinositol-3-kinase	20,44	EGFR	phosphoinositol-3-kinase	1956	5293	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Independent role of phosphoinositol-3-kinase -LRB- PI3K -RRB- and casein kinase II -LRB- CK-2 -RRB- in EGFR and Her-2-mediated constitutive NF-kappaB activation in prostate_cancer cells .
10435153	0	EGFR	34,38	proliferating_cell_nuclear_antigen	41,75	EGFR	proliferating cell nuclear antigen	1956	5111	Gene	Gene	Epidermal_growth_factor_receptor|appos|START_ENTITY Epidermal_growth_factor_receptor|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- , proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- and Ki-67 antigen in laryngeal epithelial lesions .
23690991	0	EGFR	66,70	receptor_tyrosine_kinase	20,44	EGFR	receptor tyrosine kinase	1956	5979	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	miR-219-5p inhibits receptor_tyrosine_kinase pathway by targeting EGFR in glioblastoma .
16636149	0	EGFR	24,28	sphingosine_kinase-1	89,109	EGFR	sphingosine kinase-1	1956	8877	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Estrogen transactivates EGFR via the sphingosine_1-phosphate receptor Edg-3 : the role of sphingosine_kinase-1 .
25489257	0	EGFR	50,54	thyroid_transcription_factor_1	16,46	EGFR	thyroid transcription factor 1	1956	7080	Gene	Gene	status|amod|START_ENTITY END_ENTITY|nmod|status	Relationship of thyroid_transcription_factor_1 to EGFR status in non-small-cell_lung_cancer .
17148773	0	EGFR	59,63	tyrosine_kinase	64,79	EGFR	tyrosine kinase	1956	7294	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	CYP3A phenotyping approach to predict systemic exposure to EGFR tyrosine_kinase inhibitors .
19716804	0	EGFR	19,23	tyrosine_kinase	24,39	EGFR	tyrosine kinase	1956	7294	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Erkitinib , a novel EGFR tyrosine_kinase inhibitor screened using a ProteoChip system from a phytochemical library .
26304749	0	EGFR-ERK	49,57	MMP-2	84,89	EGFR-ERK	MMP-2	1956;5594	4313	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal_cell_carcinoma .
26304749	0	EGFR-ERK	49,57	MMP-2	84,89	EGFR-ERK	MMP-2	1956;5594	4313	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal_cell_carcinoma .
20145033	0	EGFR-STAT3	66,76	Cyclooxygenase-2	0,16	EGFR-STAT3	Cyclooxygenase-2	1956;6774	5743	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes .
25893308	0	EGFR-STAT3	27,37	IGFBP2	0,6	EGFR-STAT3	IGFBP2	1956;6774	3485	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	IGFBP2 potentiates nuclear EGFR-STAT3 signaling .
25399974	0	EGFR-TKI	122,130	EGFR-TKI	60,68	EGFR-TKI	EGFR-TKI	1956	1956	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	-LSB- Therapeutic efficacy and safety of chemotherapy subsequent EGFR-TKI in advanced non-small_cell_lung_cancer patients with EGFR-TKI acquired resistance -RSB- .
25399974	0	EGFR-TKI	60,68	EGFR-TKI	122,130	EGFR-TKI	EGFR-TKI	1956	1956	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	-LSB- Therapeutic efficacy and safety of chemotherapy subsequent EGFR-TKI in advanced non-small_cell_lung_cancer patients with EGFR-TKI acquired resistance -RSB- .
15811345	0	EGF_and_TGFalpha	65,81	Ugrp2	44,49	EGF and TGFalpha	Ugrp2	13645(Tax:10090)	68662(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- expression by EGF_and_TGFalpha .
15811345	0	EGF_and_TGFalpha	65,81	uteroglobin-related_protein_2	13,42	EGF and TGFalpha	uteroglobin-related protein 2	13645(Tax:10090)	68662(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- expression by EGF_and_TGFalpha .
9178769	0	EGF_receptor	91,103	D-Cbl	0,5	EGF receptor	D-Cbl	37455(Tax:7227)	38961(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	D-Cbl , the Drosophila homologue of the c-Cbl proto-oncogene , interacts with the Drosophila EGF_receptor in vivo , despite lacking C-terminal adaptor binding sites .
6287655	0	EGF_receptor	74,86	EGF	149,152	EGF receptor	EGF	1956	1950	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Genetics of receptors for bioactive polypeptides : expression of the human EGF_receptor gene and internalization and processing of the receptor-bound EGF in human-mouse cell hybrids .
19277491	0	EGF_receptor	82,94	ERK1	18,22	EGF receptor	ERK1	13649(Tax:10090)	26417(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	Clozapine-induced ERK1 and ERK2 signaling in prefrontal cortex is mediated by the EGF_receptor .
11062025	0	EGF_receptor	58,70	ErbB2	47,52	EGF receptor	ErbB2	1956	2064	Gene	Gene	coexpressing|nmod|START_ENTITY coexpressing|dobj|END_ENTITY	Enhanced drug resistance in cells coexpressing ErbB2 with EGF_receptor or ErbB3 .
22190492	0	EGF_receptor	13,25	ErbB2	26,31	EGF receptor	ErbB2	1956	2064	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Mechanics of EGF_receptor / ErbB2 kinase activation revealed by luciferase fragment complementation imaging .
2462418	0	EGF_receptor	56,68	HER-1	70,75	EGF receptor	HER-1	1956	1956	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Effects of 8-methoxypsoralen and ultraviolet light A on EGF_receptor -LRB- HER-1 -RRB- expression .
11526509	0	EGF_receptor	132,144	HER-3	84,89	EGF receptor	HER-3	1956	2065	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Expression of herstatin , an autoinhibitor of HER-2 / neu , inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF_receptor .
11881154	0	EGF_receptor	79,91	JAK2	112,116	EGF receptor	JAK2	1956	3717	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- H2O2-induced activation of transcription factors STAT1 and STAT3 : the role of EGF_receptor and tyrosine kinase JAK2 -RSB- .
25869210	0	EGF_receptor	107,119	JAK2	0,4	EGF receptor	JAK2	1956	3717	Gene	Gene	cells|nmod|START_ENTITY erlotinib-resistance|nmod|cells overcomes|xcomp|erlotinib-resistance overcomes|nsubj|TG101348 TG101348|compound|END_ENTITY	JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small_cell_lung_carcinoma cells with mutated EGF_receptor .
21245839	0	EGF_receptor	72,84	LRRK1	27,32	EGF receptor	LRRK1	1956	79705	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF_receptor .
26280537	0	EGF_receptor	51,63	MIF	28,31	EGF receptor	MIF	1956	4282	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Secreted and O-GlcNAcylated MIF binds to the human EGF_receptor and inhibits its activation .
11252727	0	EGF_receptor	47,59	Rab5	63,67	EGF receptor	Rab5	1956	5868	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of intracellular trafficking of the EGF_receptor by Rab5 in the absence of phosphatidylinositol_3-kinase activity .
25071181	0	EGF_receptor	0,12	SOS1	18,22	EGF receptor	SOS1	1956	6654	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	EGF_receptor uses SOS1 to drive constitutive activation of NFkB in cancer cells .
19628787	0	EGF_receptor	17,29	Thrombin	0,8	EGF receptor	Thrombin	24329(Tax:10116)	29251(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Thrombin induces EGF_receptor expression and cell proliferation via a PKC -LRB- delta -RRB- / c-Src-dependent pathway in vascular smooth muscle cells .
2218496	0	EGF_receptor	71,83	erbB2	39,44	EGF receptor	erbB2	1956	2064	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|ligand ligand|nmod|product product|amod|END_ENTITY	Direct interaction of a ligand for the erbB2 oncogene product with the EGF_receptor and p185erbB2 .
15504454	0	EGF_receptor	47,59	matrix_metalloproteinase-9	83,109	EGF receptor	matrix metalloproteinase-9	1956	4318	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Roles of mitogen activated protein kinases and EGF_receptor in arsenite-stimulated matrix_metalloproteinase-9 production .
16785992	0	EGF_receptor	74,86	p38	41,44	EGF receptor	p38	1956	1432	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cisplatin induces PKB/Akt activation and p38 -LRB- MAPK -RRB- phosphorylation of the EGF_receptor .
19138820	0	EGF_receptor	24,36	p38	0,3	EGF receptor	p38	1956	5594	Gene	Gene	downregulation|compound|START_ENTITY controls|dobj|downregulation controls|nsubj|kinase kinase|nummod|END_ENTITY	p38 MAP kinase controls EGF_receptor downregulation via phosphorylation at Ser1046/1047 .
16603724	0	EGF_receptor	27,39	thyrotropin-releasing_hormone	79,108	EGF receptor	thyrotropin-releasing hormone	13649(Tax:10090)	22044(Tax:10090)	Gene	Gene	mechanism|nmod|START_ENTITY activation|nsubj|mechanism activation|nmod|END_ENTITY	The molecular mechanism of EGF_receptor activation in pancreatic beta-cells by thyrotropin-releasing_hormone .
7718322	0	EGFr	34,38	Epidermal_growth_factor_receptor	0,32	EGFr	Epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFr -RRB- expression in non-small_cell_lung_carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype .
10998445	0	EGFr	45,49	epidermal_growth_factor_receptor	11,43	EGFr	epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Profile of epidermal_growth_factor_receptor -LRB- EGFr -RRB- expression in human malignancies : effects of exposure to EGF and its biological influence on established human tumour cell lines .
7810909	0	EGFr	48,52	epidermal_growth_factor_receptor	14,46	EGFr	epidermal growth factor receptor	1956	1956	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGFr -RRB- immunoreactivity in human cutaneous nerves and sensory corpuscles .
24376930	0	EGFr	47,51	p53	42,45	EGFr	p53	1956	7157	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic and predictive significance of p53 , EGFr , Ki-67 in larynx preservation treatment .
10846174	1	EGL-1	41,46	CED-4	24,29	EGL-1	CED-4	179943(Tax:6239)	175643(Tax:6239)	Gene	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis_elegans .
9604928	0	EGL-1	23,28	CED-9	109,114	EGL-1	CED-9	179943(Tax:6239)	3565776(Tax:6239)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The C. _ elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9 .
9837929	0	EGL-1	23,28	CED-9	57,62	EGL-1	CED-9	179943(Tax:6239)	3565776(Tax:6239)	Gene	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|interaction interaction|nmod|END_ENTITY	Caenorhabditis_elegans EGL-1 disrupts the interaction of CED-9 with CED-4 and promotes CED-3 activation .
20865124	0	EGL-9	27,32	SWAN-1	11,17	EGL-9	SWAN-1	179461(Tax:6239)	179876(Tax:6239)	Gene	Gene	Binds|nmod|START_ENTITY Binds|compound|END_ENTITY	C. _ elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas_aeruginosa PAO1 .
15911573	0	EGO-1	0,5	GLP-1	96,101	EGO-1	GLP-1	172524(Tax:6239)	176286(Tax:6239)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|signaling signaling|compound|END_ENTITY	EGO-1 , a putative RNA-directed RNA polymerase , promotes germline proliferation in parallel with GLP-1 / notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in Caenorhabditis_elegans .
11358833	0	EGP-2	31,36	EGP-2	88,93	EGP-2	EGP-2	17075(Tax:10090)	17075(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	The epithelial glycoprotein 2 -LRB- EGP-2 -RRB- promoter-driven epithelial-specific expression of EGP-2 in transgenic_mice : a new model to study carcinoma-directed immunotherapy .
11358833	0	EGP-2	88,93	EGP-2	31,36	EGP-2	EGP-2	17075(Tax:10090)	17075(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	The epithelial glycoprotein 2 -LRB- EGP-2 -RRB- promoter-driven epithelial-specific expression of EGP-2 in transgenic_mice : a new model to study carcinoma-directed immunotherapy .
17764926	0	EGR-1	86,91	ATF3	77,81	EGR-1	ATF3	1958	467	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Green tea catechin _ -LRB- - -RRB- - epicatechin_gallate induces tumour suppressor protein ATF3 via EGR-1 activation .
22230687	0	EGR-1	58,63	ATF3	74,78	EGR-1	ATF3	1958	467	Gene	Gene	dependent|amod|START_ENTITY up-regulation|amod|dependent up-regulation|compound|END_ENTITY	Patulin induces colorectal_cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation .
25997867	0	EGR-1	0,5	Bax	6,9	EGR-1	Bax	1958	581	Gene	Gene	START_ENTITY|appos|plays plays|nsubj|END_ENTITY	EGR-1 / Bax pathway plays a role in vitamin E - tocotrienol-induced apoptosis in pancreatic_cancer cells .
19074849	0	EGR-1	6,11	ESE-1	0,5	EGR-1	ESE-1	1958	1999	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|appos|plays	ESE-1 / EGR-1 pathway plays a role in tolfenamic_acid-induced apoptosis in colorectal_cancer cells .
21983072	0	EGR-1	13,18	GGPPS	0,5	EGR-1	GGPPS	1958	9453	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	GGPPS , a new EGR-1 target gene , reactivates ERK_1 / 2 signaling through increasing Ras prenylation .
20417178	0	EGR-1	0,5	Ho-1	16,20	EGR-1	Ho-1	13653(Tax:10090)	15368(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	EGR-1 regulates Ho-1 expression induced by cigarette smoke .
22115966	0	EGR-1	34,39	IGF-1R	13,19	EGR-1	IGF-1R	1958	3480	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate_cancer cells .
12427750	0	EGR-1	23,28	NAB2	0,4	EGR-1	NAB2	13653(Tax:10090)	17937(Tax:10090)	Gene	Gene	corepressor|nmod|START_ENTITY END_ENTITY|appos|corepressor	NAB2 , a corepressor of EGR-1 , inhibits vascular_endothelial_growth_factor-mediated gene induction and angiogenic responses of endothelial cells .
20121949	0	EGR-1	22,27	Snail	0,5	EGR-1	Snail	1958	6615	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b .
2064996	0	EGR-1	59,64	granulocyte-macrophage_colony-stimulating_factor	73,121	EGR-1	granulocyte-macrophage colony-stimulating factor	1958	1437	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage_colony-stimulating_factor in human U-937 monocytic_leukemia cells : involvement of a pertussis toxin-sensitive G protein .
17099140	0	EGR-1	67,72	matrix_metalloproteinase-2	27,53	EGR-1	matrix metalloproteinase-2	1958	4313	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Cigarette smoke stimulates matrix_metalloproteinase-2 activity via EGR-1 in human lung fibroblasts .
1633113	0	EGR-1	14,19	oncostatin_M	57,69	EGR-1	oncostatin M	1958	5008	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of EGR-1 , c-jun , and c-myc gene expression by oncostatin_M .
9359835	0	EGR-1	90,95	prohormone_convertase_2	20,43	EGR-1	prohormone convertase 2	1958	5126	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of human prohormone_convertase_2 promoter activity by the transcription factor EGR-1 .
12470865	0	EGR-1	6,11	zif268	13,19	EGR-1	zif268	1958	1958	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Basal EGR-1 -LRB- zif268 , NGFI-A , Krox-24 -RRB- expression in developing striatal patches : role of dopamine and glutamate .
16849326	0	EGR1	68,72	AMP-activated_kinase	86,106	EGR1	AMP-activated kinase	1958	5563	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated_kinase .
21998680	0	EGR1	64,68	EGF	52,55	EGR1	EGF	1958	1950	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Coordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability .
22593802	0	EGR1	30,34	EGF	38,41	EGR1	EGF	1958	1950	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate_Cancer Cells .
19414352	0	EGR1	27,31	EGFR	0,4	EGR1	EGFR	1958	1956	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	EGFR mutation up-regulates EGR1 expression through the ERK pathway .
19414352	0	EGR1	27,31	ERK	55,58	EGR1	ERK	1958	2048	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	EGFR mutation up-regulates EGR1 expression through the ERK pathway .
26343742	0	EGR1	121,125	Histone_Deacetylase	0,19	EGR1	Histone Deacetylase	1958	9734	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Histone_Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early_Growth_Response_Protein_1 -LRB- EGR1 -RRB- in Colorectal_Cancer_Cells .
23029358	0	EGR1	30,34	MAML1	0,5	EGR1	MAML1	1958	9794	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters : implications for nephrogenesis and the development of renal_cancer .
17916653	0	EGR1	146,150	early_growth_response_1	116,139	EGR1	early growth response 1	407125(Tax:9913)	407125(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prostaglandin_F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early_growth_response_1 gene -LRB- EGR1 -RRB- in the bovine corpus luteum .
23857582	0	EGR1	192,196	early_growth_response_1	167,190	EGR1	early growth response 1	1958	1958	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein -LRB- HnRNP -RRB- K genome-wide binding survey reveals its role in regulating 3 ' - end RNA processing and transcription termination at the early_growth_response_1 -LRB- EGR1 -RRB- gene through XRN2 exonuclease .
25028509	0	EGR1	172,176	early_growth_response_1	147,170	EGR1	early growth response 1	1958	1958	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A mitogen-activated_protein_kinase / extracellular_signal-regulated_kinase_kinase -LRB- MEK -RRB- - dependent transcriptional program controls activation of the early_growth_response_1 -LRB- EGR1 -RRB- gene during amino_acid limitation .
20514024	0	EGR1	0,4	histone_deacetylase	21,40	EGR1	histone deacetylase	1958	9734	Gene	Gene	reactivation|nummod|START_ENTITY reactivation|nmod|inhibitors inhibitors|amod|END_ENTITY	EGR1 reactivation by histone_deacetylase inhibitors promotes synovial_sarcoma cell death through the PTEN tumor suppressor .
25108236	0	EGR1	81,85	mPGES-1	97,104	EGR1	mPGES-1	1958	64292(Tax:10090)	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	15d-PGJ decreases PGE synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter .
25548232	0	EGR2	27,31	CD26	80,84	EGR2	CD26	1959	1803	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|Pathway Pathway|compound|END_ENTITY	CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway .
20067763	0	EGR2	94,98	MiR-150	0,7	EGR2	MiR-150	1959	406942	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	MiR-150 promotes gastric_cancer proliferation by negatively regulating the pro-apoptotic gene EGR2 .
22510410	0	EGR2	42,46	SCD5	25,29	EGR2	SCD5	100297981	617419(Tax:9913)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the bovine SCD5 promoter by EGR2 and SREBP1 .
10369870	0	EGR2	74,78	early_growth_response_2	44,67	EGR2	early growth response 2	1959	1959	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional consequences of mutations in the early_growth_response_2 gene -LRB- EGR2 -RRB- correlate with severity of human myelinopathies .
26119399	0	EGR2	41,45	early_growth_response_2	16,39	EGR2	early growth response 2	1959	1959	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Resequencing of early_growth_response_2 -LRB- EGR2 -RRB- gene revealed a recurrent patient-specific mutation in schizophrenia .
9537424	0	EGR2	42,46	early_growth_response_2	17,40	EGR2	early growth response 2	1959	1959	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the early_growth_response_2 -LRB- EGR2 -RRB- gene are associated with hereditary myelinopathies .
22276163	0	EGR3	74,78	early_growth_response_3	49,72	EGR3	early growth response 3	1960	1960	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic evidence for the association between the early_growth_response_3 -LRB- EGR3 -RRB- gene and schizophrenia .
20573983	0	EHBP-1	0,6	RAB-10	22,28	EHBP-1	RAB-10	179343(Tax:6239)	266836(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis_elegans .
21177873	0	EHD1	29,33	Fer1L5	71,77	EHD1	Fer1L5	10938	90342	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 -LRB- Fer1L5 -RRB- and mediate myoblast fusion .
19864458	0	EHD1	15,19	MICAL-L1	0,8	EHD1	MICAL-L1	10938	85377	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling .
11423532	0	EHD1	58,62	insulin-like_growth_factor_1_receptor	15,52	EHD1	insulin-like growth factor 1 receptor	100761397	100768531	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of insulin-like_growth_factor_1_receptor with EHD1 and SNAP29 .
25758127	0	EHD2	44,48	E-cadherin	93,103	EHD2	E-cadherin	30846	999	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Decreased expression and prognostic role of EHD2 in human breast_carcinoma : correlation with E-cadherin .
15182197	0	EHD2	0,4	insulin-responsive_glucose_transporter	24,62	EHD2	insulin-responsive glucose transporter	361512(Tax:10116)	25139(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	EHD2 interacts with the insulin-responsive_glucose_transporter -LRB- GLUT4 -RRB- in rat adipocytes and may participate in insulin-induced GLUT4 recruitment .
18502764	0	EHD2	32,36	myoferlin	52,61	EHD2	myoferlin	30846	26509	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion .
9370297	0	EHOC-1	38,44	GT334	31,36	EHOC-1	GT334	7109	54049	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure of the human GT334 -LRB- EHOC-1 -RRB- gene mapping to 21q22 .3 .
12586827	0	EID-1	8,13	EID-2	29,34	EID-1	EID-2	23741	163126	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	A novel EID-1 family member , EID-2 , associates with histone deacetylases and inhibits muscle differentiation .
18182853	0	EID-1	0,5	SF-1	45,49	EID-1	SF-1	23741	7536	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	EID-1 interacts with orphan nuclear receptor SF-1 and represses its transactivation .
12586827	0	EID-2	29,34	EID-1	8,13	EID-2	EID-1	163126	23741	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	A novel EID-1 family member , EID-2 , associates with histone deacetylases and inhibits muscle differentiation .
14585496	0	EID-2	0,5	MyoD	93,97	EID-2	MyoD	163126	4654	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	EID-2 , a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD .
25607115	0	EIF2AK2	50,57	NLRP3	20,25	EIF2AK2	NLRP3	5610	114548	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory_bowel_disease .
15723074	0	EIF2B5	0,6	GFAP	28,32	EIF2B5	GFAP	8893	2670	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	EIF2B5 mutations compromise GFAP + astrocyte generation in vanishing_white_matter_leukodystrophy .
10644445	0	EIF4A1	49,55	eukaryotic_initiation_factor_4AI	10,42	EIF4A1	eukaryotic initiation factor 4AI	1973	1973	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human eukaryotic_initiation_factor_4AI gene -LRB- EIF4A1 -RRB- contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines .
26300542	0	EIF4G1	60,66	VPS35	22,27	EIF4G1	VPS35	1981	55737	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population .
27003362	0	EIF4G1	71,77	eukaryotic_translation_initiation_factor_4_gamma_1	19,69	EIF4G1	eukaryotic translation initiation factor 4 gamma 1	1981	1981	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Functional role of eukaryotic_translation_initiation_factor_4_gamma_1 -LRB- EIF4G1 -RRB- in NSCLC .
23132950	0	EIN2	42,46	CTR1	0,4	EIN2	CTR1	831889(Tax:3702)	831748(Tax:3702)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis .
24114213	0	EIN3	72,76	ethylene_insensitive3	49,70	EIN3	ethylene insensitive3	101206055	101206055	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning and expression analysis of the ethylene_insensitive3 -LRB- EIN3 -RRB- gene in cucumber -LRB- Cucumis_sativus -RRB- .
12049804	0	EJM2	93,97	CHRNA7	44,50	EJM2	CHRNA7	50715	1139	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the positional candidate gene CHRNA7 at the juvenile_myoclonic_epilepsy locus -LRB- EJM2 -RRB- on chromosome 15q13-14 .
25197097	0	EKLF	21,25	HIRA	70,74	EKLF	HIRA	10661	7290	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	Transcription factor EKLF -LRB- KLF1 -RRB- recruitment of the histone chaperone HIRA is essential for b-globin gene expression .
24866116	0	EKLF	35,39	KLF1	41,45	EKLF	KLF1	10661	10661	Gene	Gene	control|nmod|START_ENTITY control|appos|END_ENTITY	Extrinsic and intrinsic control by EKLF -LRB- KLF1 -RRB- within a specialized erythroid niche .
8195185	0	EKLF	49,53	erythroid_Kruppel-like_factor	18,47	EKLF	erythroid Kruppel-like factor	10661	10661	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of the erythroid_Kruppel-like_factor -LRB- EKLF -RRB- gene promoter by the erythroid transcription factor GATA-1 .
25577996	0	EL	103,105	VCAM-1	85,91	EL	VCAM-1	9388	7412	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-a-induced VCAM-1 , ICAM-1and EL expression via the NF-kB pathway .
10996389	0	EL-4	67,71	HSP70	42,47	EL-4	HSP70	111979(Tax:10090)	15511(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Splenic cytotoxic cells recognize surface HSP70 on culture-adapted EL-4 mouse_lymphoma cells .
9925799	0	EL-4	100,104	IL-2	71,75	EL-4	IL-2	111979(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Propanil affects transcriptional and posttranscriptional regulation of IL-2 expression in activated EL-4 cells .
21806999	0	EL-4	65,69	IL-4	37,41	EL-4	IL-4	111979(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction .
16046709	0	EL-4	139,143	IRAK	116,120	EL-4	IRAK	111979(Tax:10090)	16179(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Curcumin blocks interleukin-1 -LRB- IL-1 -RRB- signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells .
14585371	0	EL1	59,62	MDS1-EVI1-like-1	18,34	EL1	MDS1-EVI1-like-1	2035	63976	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Low expression of MDS1-EVI1-like-1 -LRB- MEL1 -RRB- and EVI1-like-1 -LRB- EL1 -RRB- genes in favorable-risk acute_myeloid_leukemia .
25493215	0	EL4	90,93	BV8	62,65	EL4	BV8	111979(Tax:10090)	50501(Tax:10090)	Gene	Gene	PROTEIN|nmod|START_ENTITY PROTEIN|compound|END_ENTITY	GRANULOCYTE INFILTRATION AND EXPRESSION OF THE PRO-ANGIOGENIC BV8 PROTEIN IN EXPERIMENTAL EL4 AND LEWIS LUNG CARCINOMA TUMORS .
15061764	0	EL4	18,21	CD4	0,3	EL4	CD4	111979(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection .
10640296	0	EL4	139,142	interleukin-2	89,102	EL4	interleukin-2	111979(Tax:10090)	16183(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY cannabinol|nmod|T-cells transcription|nmod|cannabinol Role|acl|transcription Role|nmod|gene gene|compound|END_ENTITY	Role of nuclear factor of activated T-cells and activator_protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells .
8136944	0	EL4	31,34	interleukin-2	14,27	EL4	interleukin-2	111979(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Production of interleukin-2 by EL4 tumor cells induces natural killer cell - and T-cell-mediated immunity .
9224627	0	EL4	110,113	interleukin_1alpha	88,106	EL4	interleukin 1alpha	111979(Tax:10090)	16175(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Staurosporine , but not Ro_31-8220 , induces interleukin_2 production and synergizes with interleukin_1alpha in EL4 thymoma cells .
17296727	0	ELA1	0,4	ELC1	38,42	ELA1	ELC1	855491(Tax:4932)	856061(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells .
17412886	0	ELA2	12,16	CD34	31,35	ELA2	CD34	24332(Tax:10116)	305081(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	High PR3 or ELA2 expression by CD34 + cells in advanced-phase chronic_myeloid_leukemia is associated with improved outcome following allogeneic stem_cell_transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects .
7516056	0	ELAM-1	36,42	E-selectin	24,34	ELAM-1	E-selectin	6401	6401	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of soluble E-selectin -LRB- ELAM-1 -RRB- in immune-mediated neuropathies .
1697876	0	ELAM-1	60,66	IFN-gamma	0,9	ELAM-1	IFN-gamma	6401	3458	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro .
1381227	0	ELAM-1	36,42	Tumour_necrosis_factor	0,22	ELAM-1	Tumour necrosis factor	6401	7124	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Tumour_necrosis_factor induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells -- analysis of tumour_necrosis_factor-receptor interactions .
1713680	0	ELAM-1	57,63	endothelial-leukocyte_adhesion_molecule_1	14,55	ELAM-1	endothelial-leukocyte adhesion molecule 1	6401	6401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Activation of endothelial-leukocyte_adhesion_molecule_1 -LRB- ELAM-1 -RRB- gene transcription .
1717513	0	ELAM-1	51,57	endothelial-leukocyte_adhesion_molecule_1	8,49	ELAM-1	endothelial-leukocyte adhesion molecule 1	25544(Tax:10116)	25544(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of endothelial-leukocyte_adhesion_molecule_1 -LRB- ELAM-1 -RRB- in neutrophil-mediated lung_injury in rats .
7514772	0	ELAM-1	57,63	endothelial_leukocyte_adhesion_molecule-1	14,55	ELAM-1	endothelial leukocyte adhesion molecule-1	6401	6401	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of endothelial_leukocyte_adhesion_molecule-1 -LRB- ELAM-1 -RRB- in chronic_inflammatory_demyelinating_polyneuropathy .
7685818	0	ELAM-1	61,67	endothelial_leukocyte_adhesion_molecule-1	18,59	ELAM-1	endothelial leukocyte adhesion molecule-1	6401	6401	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the endothelial_leukocyte_adhesion_molecule-1 -LRB- ELAM-1 -RRB- on endothelial cells in experimental gingivitis in humans .
1710341	0	ELAM-1	127,133	endothelial_leukocyte_adhesion_molecule_1	84,125	ELAM-1	endothelial leukocyte adhesion molecule 1	6401	6401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial_leukocyte_adhesion_molecule_1 -LRB- ELAM-1 -RRB- gene transcription .
1903840	0	ELAV	64,68	elav	27,31	ELAV	elav	31000(Tax:7227)	31000(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY gene|nmod|protein gene|amod|END_ENTITY	Organizational analysis of elav gene and functional analysis of ELAV protein of Drosophila_melanogaster and Drosophila_virilis .
10222066	0	ELC	62,65	CCR7	0,4	ELC	CCR7	6363	1236	Gene	Gene	ligands|appos|START_ENTITY ligands|nummod|END_ENTITY	CCR7 ligands , SLC/6Ckine/Exodus2 / TCA4 and CKbeta-11 / MIP-3beta / ELC , are chemoattractants for CD56 -LRB- + -RRB- CD16 -LRB- - -RRB- NK cells and late stage lymphoid progenitors .
17296727	0	ELC1	38,42	ELA1	0,4	ELC1	ELA1	856061(Tax:4932)	855491(Tax:4932)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells .
26349199	0	ELECTRON_TRANSFERRING_FLAVOPROTEIN_DEHYDROGENASE	22,70	ETFDH	72,77	ELECTRON TRANSFERRING FLAVOPROTEIN DEHYDROGENASE	ETFDH	2110	2110	Gene	Gene	GENE|compound|START_ENTITY GENE|appos|END_ENTITY	NOVEL MUTATION OF THE ELECTRON_TRANSFERRING_FLAVOPROTEIN_DEHYDROGENASE -LRB- ETFDH -RRB- GENE IN THE ISOLATED MYOPATHIC FORM OF COENZYME q10 DEFICIENCY .
7876076	0	ELF-1	117,122	Mek-4	132,137	ELF-1	Mek-4	13709(Tax:10090)	13837(Tax:10090)	Gene	Gene	ligand|appos|START_ENTITY ligand|nmod|END_ENTITY	cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand -LRB- ELF-1 -RRB- for the Mek-4 and Sek receptor protein-tyrosine kinases .
10049594	0	ELF3	34,38	ESX	46,49	ELF3	ESX	1999	1999	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the human ELF3 -LRB- ESE-1 / ESX -RRB- gene , a member of the Ets transcription factor family , and identification of a functional promoter .
20147293	0	ELG1	6,10	proliferating_cell_nuclear_antigen	48,82	ELG1	proliferating cell nuclear antigen	79915	5111	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|level level|nmod|END_ENTITY	Human ELG1 regulates the level of ubiquitinated proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- through Its interactions with PCNA and USP1 .
24867259	0	ELK1	49,53	BCL2A1	17,23	ELK1	BCL2A1	2002	597	Gene	Gene	activating|dobj|START_ENTITY induces|advcl|activating induces|dobj|expression expression|compound|END_ENTITY	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1 / 2 pathway .
9108030	0	ELL	25,28	ELL2	0,4	ELL	ELL2	8178	22936	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	ELL2 , a new member of an ELL family of RNA polymerase II elongation factors .
27009366	0	ELL	0,3	c-Myc	12,17	ELL	c-Myc	8178	4609	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	ELL targets c-Myc for proteasomal degradation and suppresses tumour growth .
11979508	0	ELL	64,67	dELL	0,4	ELL	dELL	40171(Tax:7227)	40171(Tax:7227)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	dELL , a drosophila homologue of transcription elongation factor ELL -LRB- Eleven-nineteen Lysine rich_Leukemia -RRB- , is required for early development .
14517999	0	ELL-associated_factor_2	21,44	Eaf2	46,50	ELL-associated factor 2	Eaf2	106389(Tax:10090)	106389(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of murine ELL-associated_factor_2 -LRB- Eaf2 -RRB- is developmentally regulated .
9108030	0	ELL2	0,4	ELL	25,28	ELL2	ELL	22936	8178	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	ELL2 , a new member of an ELL family of RNA polymerase II elongation factors .
26370086	0	ELL_Protein-associated_Factor_2	0,31	Smad3	121,126	ELL Protein-associated Factor 2	Smad3	55840	4088	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|END_ENTITY	ELL_Protein-associated_Factor_2 -LRB- EAF2 -RRB- Inhibits Transforming Growth Factor b Signaling through a Direct Interaction with Smad3 .
19439446	0	ELMO2	41,46	Integrin-linked_kinase	0,22	ELMO2	Integrin-linked kinase	63916	3611	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Integrin-linked_kinase interactions with ELMO2 modulate cell polarity .
16820942	0	ELN	43,46	elastin	29,36	ELN	elastin	2006	2006	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel mutations in the human elastin gene -LRB- ELN -RRB- causing isolated supravalvular_aortic_stenosis .
20926252	0	ELN	61,64	elastin	47,54	ELN	elastin	2006	2006	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence for heterozygous abnormalities of the elastin gene -LRB- ELN -RRB- affecting the quantity of vocal fold elastic fibers : a pilot study .
7625763	0	ELN	42,45	elastin	33,40	ELN	elastin	2006	2006	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular variation of the human elastin -LRB- ELN -RRB- gene in a normal human population .
7909531	0	ELN	49,52	elastin	35,42	ELN	elastin	2006	2006	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Two new polymorphisms in the human elastin gene -LRB- ELN -RRB- .
9873040	0	ELN	77,80	elastin	63,70	ELN	elastin	2006	2006	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cutis_laxa arising from frameshift mutations in exon 30 of the elastin gene -LRB- ELN -RRB- .
24644051	0	ELOVL4	25,31	ELOVL4	76,82	ELOVL4	ELOVL4	83603(Tax:10090)	83603(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4 .
24644051	0	ELOVL4	76,82	ELOVL4	25,31	ELOVL4	ELOVL4	83603(Tax:10090)	83603(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4 .
3010492	0	ELP	51,54	elastase-like_proteinase	25,49	ELP	elastase-like proteinase	2516	2516	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of granulocyte elastase-like_proteinase -LRB- ELP -RRB- on platelet functions .
18996918	0	ELP3	37,41	elongator_protein_3	16,35	ELP3	elongator protein 3	55140	55140	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of the elongator_protein_3 -LRB- ELP3 -RRB- gene are associated with motor neuron_degeneration .
25301525	0	ELP4	89,93	BDNF	50,54	ELP4	BDNF	26610	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Association of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and elongator_protein_complex_4 -LRB- ELP4 -RRB- polymorphisms with benign_epilepsy with centrotemporal_spikes in a Greek population .
20186130	0	EMILIN1	59,66	elastin_microfibril_interfacer_1	25,57	EMILIN1	elastin microfibril interfacer 1	11117	11117	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of the elastin_microfibril_interfacer_1 -LRB- EMILIN1 -RRB- gene in essential hypertension .
24793016	0	EMMPRIN	26,33	ADAM17	0,6	EMMPRIN	ADAM17	682	6868	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	ADAM17 is associated with EMMPRIN and predicts poor prognosis in patients with uterine cervical_carcinoma .
20451562	0	EMMPRIN	23,30	Angiotensin_II	0,14	EMMPRIN	Angiotensin II	682	183	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces EMMPRIN expression in THP-1 macrophages via the NF-kappaB pathway .
17114117	0	EMMPRIN	22,29	CD147	31,36	EMMPRIN	CD147	682	682	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of EMMPRIN -LRB- CD147 -RRB- in the human eye and detection of soluble form of EMMPRIN in ocular fluids .
19863615	0	EMMPRIN	0,7	CD147	9,14	EMMPRIN	CD147	682	682	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- expression and differentiation of papillary thyroid_carcinoma : implications for immunocytochemistry in FNA cytology .
25824988	0	EMMPRIN	14,21	CD147	23,28	EMMPRIN	CD147	682	682	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of EMMPRIN -LRB- CD147 -RRB- on monocyte subsets in patients with symptomatic coronary_artery_disease .
25550208	0	EMMPRIN	52,59	Cyclophilin_A	14,27	EMMPRIN	Cyclophilin A	12215(Tax:10090)	268373(Tax:10090)	Gene	Gene	Activates|dobj|START_ENTITY Activates|nsubj|END_ENTITY	Extracellular Cyclophilin_A Activates Platelets Via EMMPRIN -LRB- CD147 -RRB- and PI3K/Akt Signaling , Which Promotes Platelet Adhesion and Thrombus Formation In Vitro and In Vivo .
24832574	0	EMMPRIN	58,65	Extracellular_Matrix_Metalloproteinase_Inducer	10,56	EMMPRIN	Extracellular Matrix Metalloproteinase Inducer	682	682	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Increased Extracellular_Matrix_Metalloproteinase_Inducer -LRB- EMMPRIN -RRB- Expression in the Conjunctival Epithelium Exposed to Antiglaucoma Treatments .
24374756	0	EMMPRIN	48,55	Extracellular_matrix_metalloproteinase_inducer	0,46	EMMPRIN	Extracellular matrix metalloproteinase inducer	682	682	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- expression correlates positively with active angiogenesis and negatively with basic_fibroblast_growth_factor expression in epithelial_ovarian_cancer .
19350111	0	EMMPRIN	0,7	GPVI	49,53	EMMPRIN	GPVI	682	51206	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction .
20693392	0	EMMPRIN	112,119	Interleukin-18	0,14	EMMPRIN	Interleukin-18	682	3606	Gene	Gene	part|nmod|START_ENTITY induces|nmod|part induces|nsubj|END_ENTITY	Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation .
20693392	0	EMMPRIN	23,30	Interleukin-18	0,14	EMMPRIN	Interleukin-18	682	3606	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation .
25807898	0	EMMPRIN	0,7	Kindlin-3	56,65	EMMPRIN	Kindlin-3	682	83706	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	EMMPRIN regulates b1 integrin-mediated adhesion through Kindlin-3 in human melanoma cells .
16046057	0	EMMPRIN	133,140	MMP-2	148,153	EMMPRIN	MMP-2	682	4313	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of reversion-inducing_cysteine-rich_protein_with_kazal_motifs -LRB- RECK -RRB- and extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- , with MMP-2 , MMP-9 , and survival in colorectal_cancer .
18035727	0	EMMPRIN	101,108	MMP-2	41,46	EMMPRIN	MMP-2	682	4313	Gene	Gene	matrix_metalloproteinase|appos|START_ENTITY matrix_metalloproteinase|appos|END_ENTITY	-LSB- Expression of matrix_metalloproteinase -LRB- MMP-2 -RRB- and extracellular matrix_metalloproteinases inducer -LRB- EMMPRIN -RRB- in benign and advanced breast_cancer tissue samples -RSB- .
21355964	0	EMMPRIN	0,7	MMP-9	30,35	EMMPRIN	MMP-9	682	4318	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- regulation of MMP-9 in bronchial epithelial cells in COPD .
12173047	0	EMMPRIN	27,34	MMP2	57,61	EMMPRIN	MMP2	682	4313	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Breast_cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A -LRB- 2 -RRB- and 5-lipoxygenase catalyzed pathway .
19758589	0	EMMPRIN	0,7	MT1-MMP	46,53	EMMPRIN	MT1-MMP	682	4323	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	EMMPRIN and its ligand cyclophilin_A regulate MT1-MMP , MMP-9 and M-CSF during foam cell formation .
26024713	0	EMMPRIN	24,31	Monocarboxylate_Transporter_1	117,146	EMMPRIN	Monocarboxylate Transporter 1	682	6566	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|nmod|END_ENTITY	Recombinant Multivalent EMMPRIN Extracellular Domain Induces U937 Human Leukemia Cell Apoptosis by Downregulation of Monocarboxylate_Transporter_1 and Activation of Procaspase-9 .
26024713	0	EMMPRIN	24,31	Monocarboxylate_Transporter_1	117,146	EMMPRIN	Monocarboxylate Transporter 1	682	6566	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|nmod|END_ENTITY	Recombinant Multivalent EMMPRIN Extracellular Domain Induces U937 Human Leukemia Cell Apoptosis by Downregulation of Monocarboxylate_Transporter_1 and Activation of Procaspase-9 .
18647594	0	EMMPRIN	21,28	P38	44,47	EMMPRIN	P38	682	5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathways pathways|compound|END_ENTITY	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells .
16860414	0	EMMPRIN	47,54	PPAR	21,25	EMMPRIN	PPAR	682	5465	Gene	Gene	expression|nmod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells .
22782346	0	EMMPRIN	0,7	S100A4	27,33	EMMPRIN	S100A4	682	6275	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal_cancer .
23135911	0	EMMPRIN	28,35	S100A9	0,6	EMMPRIN	S100A9	12215(Tax:10090)	20202(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis .
21508366	0	EMMPRIN	0,7	SCC	27,30	EMMPRIN	SCC	682	6317	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	EMMPRIN expression in oral SCC is regulated by FYN kinase .
20563831	0	EMMPRIN	98,105	angiotensin_II	32,46	EMMPRIN	angiotensin II	682	183	Gene	Gene	extracellular_matrix_metalloproteinase_inducer|appos|START_ENTITY END_ENTITY|nmod|extracellular_matrix_metalloproteinase_inducer	The effect of the expression of angiotensin_II on extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- in macrophages is mediated via the AT1/COX -2 / PGE2 pathway .
14985463	0	EMMPRIN	106,113	extracellular_matrix_metalloproteinase_inducer	58,104	EMMPRIN	extracellular matrix metalloproteinase inducer	682	682	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tumor-stroma interaction : positive feedback regulation of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN .
19639092	0	EMMPRIN	62,69	extracellular_matrix_metalloproteinase_inducer	14,60	EMMPRIN	extracellular matrix metalloproteinase inducer	682	682	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- in healthy and inflamed human gingival .
20412416	0	EMMPRIN	92,99	extracellular_matrix_metalloproteinase_inducer	44,90	EMMPRIN	extracellular matrix metalloproteinase inducer	25246(Tax:10116)	25246(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The temporal expression and localization of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- during the development of periodontitis in an animal model .
24488920	0	EMMPRIN	62,69	extracellular_matrix_metalloproteinase_inducer	14,60	EMMPRIN	extracellular matrix metalloproteinase inducer	682	682	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- in the endometrium of patients with repeated_implantation_failure after in vitro fertilization .
16046057	0	EMMPRIN	133,140	reversion-inducing_cysteine-rich_protein_with_kazal_motifs	15,73	EMMPRIN	reversion-inducing cysteine-rich protein with kazal motifs	682	8434	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of reversion-inducing_cysteine-rich_protein_with_kazal_motifs -LRB- RECK -RRB- and extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- , with MMP-2 , MMP-9 , and survival in colorectal_cancer .
16778084	0	EMMPRIN	63,70	vascular_endothelial_growth_factor	14,48	EMMPRIN	vascular endothelial growth factor	682	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by EMMPRIN via the PI3K-Akt signaling pathway .
9126480	0	EMP1	109,113	CL-20	97,102	EMP1	CL-20	2012	2012	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	cDNA cloning , genomic structure , and chromosome mapping of the human epithelial membrane protein CL-20 gene -LRB- EMP1 -RRB- , a member of the PMP22 family .
25394671	0	EMP1	86,90	SOS1	0,4	EMP1	SOS1	2012	6654	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1 .
24338711	0	EMP1	0,4	caspase-9	15,24	EMP1	caspase-9	2012	842	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	EMP1 regulates caspase-9 and VEGFC expression and suppresses prostate_cancer cell proliferation and invasion .
17609206	0	EMP2	22,26	caveolin-1	51,61	EMP2	caveolin-1	2013	857	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The tetraspan protein EMP2 regulates expression of caveolin-1 .
10903844	0	EMR2	6,10	CD97	82,86	EMR2	CD97	30817	976	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	Human EMR2 , a novel EGF-TM7 molecule on chromosome 19p13 .1 , is closely related to CD97 .
15947784	0	EMSY	11,15	HP1beta	19,26	EMSY	HP1beta	56946	10951	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of EMSY to HP1beta : implications for recruitment of HP1beta and BS69 .
24582497	0	EMSY	27,31	miR-31	83,89	EMSY	miR-31	56946	407035	Gene	Gene	represses|nsubj|START_ENTITY represses|xcomp|END_ENTITY	The breast_cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31 .
21822312	0	EMT	49,52	EGFR	25,29	EMT	EGFR	3702	1956	Gene	Gene	features|compound|START_ENTITY induce|dobj|features activity|acl|induce activity|amod|END_ENTITY	Loss of EBP50 stimulates EGFR activity to induce EMT phenotypic features in biliary_cancer cells .
26483386	0	EMT	41,44	EGFR	110,114	EMT	EGFR	3702	1956	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Carcinoma cells induce lumen filling and EMT in epithelial cells by soluble E-cadherin-mediated activation of EGFR .
26741322	0	EMT	59,62	EGFR	114,118	EMT	EGFR	16428(Tax:10090)	13649(Tax:10090)	Gene	Gene	macrophage|dobj|START_ENTITY macrophage|nmod|downregulation downregulation|nmod|pathway pathway|amod|END_ENTITY	Cannabinoid receptor-2 agonist inhibits macrophage induced EMT in non-small cell lung_cancer by downregulation of EGFR pathway .
26958807	0	EMT	68,71	EGFR	31,35	EMT	EGFR	3702	1956	Gene	Gene	metastasis|nmod|START_ENTITY activates|nmod|metastasis activates|dobj|pathway pathway|amod|END_ENTITY	Autocrine epiregulin activates EGFR pathway for lung metastasis via EMT in salivary adenoid_cystic_carcinoma .
23945276	0	EMT	75,78	HMGA1	0,5	EMT	HMGA1	3702	3159	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	HMGA1 promotes metastatic processes in basal-like breast_cancer regulating EMT and stemness .
26250458	0	EMT	44,47	HMGA2	21,26	EMT	HMGA2	3702	8091	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	The critical role of HMGA2 in regulation of EMT in epithelial ovarian_carcinomas .
26250458	0	EMT	44,47	HMGA2	21,26	EMT	HMGA2	3702	8091	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	The critical role of HMGA2 in regulation of EMT in epithelial ovarian_carcinomas .
8609388	0	EMT	115,118	LCK	73,76	EMT	LCK	3702	3932	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	The EMT/ITK/TSK -LRB- EMT -RRB- tyrosine kinase is activated during TCR signaling : LCK is required for optimal activation of EMT .
23326605	0	EMT	35,38	SFRP4	19,24	EMT	SFRP4	3702	6424	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The Wnt gatekeeper SFRP4 modulates EMT , cell migration and downstream Wnt signalling in serous ovarian_cancer cells .
25518932	0	EMT	65,68	TGF-b	46,51	EMT	TGF-b	3702	7040	Gene	Gene	Signaling|nmod|START_ENTITY END_ENTITY|xcomp|Signaling	Itch E3 Ubiquitin Ligase Positively Regulates TGF-b Signaling to EMT via Smad7 Ubiquitination .
26305550	0	EMT	129,132	TNF-a	144,149	EMT	TNF-a	16428(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Curcumin combined with FAPac vaccine elicits effective antitumor response by targeting indolamine-2 ,3 - dioxygenase and inhibiting EMT induced by TNF-a in melanoma .
24903376	0	EMT	67,70	TRPM8	0,5	EMT	TRPM8	3702	79054	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	TRPM8 promotes aggressiveness of breast_cancer cells by regulating EMT via activating AKT/GSK -3 b pathway .
26884980	0	EMT	59,62	miR-129-5p	30,40	EMT	miR-129-5p	3702	100302178	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	MicroRNA profiling identifies miR-129-5p as a regulator of EMT in tubular epithelial cells .
21651764	0	EMX2	73,77	teneurin-1	6,16	EMX2	teneurin-1	2018	10178	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter .
23423141	0	EN-2	46,50	engrailed-2	33,44	EN-2	engrailed-2	2020	2020	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Complex epigenetic regulation of engrailed-2 -LRB- EN-2 -RRB- homeobox gene in the autism cerebellum .
20847094	0	EN-RAGE	120,127	RAGE	107,111	EN-RAGE	RAGE	6283	101669765	Gene	Gene	ligand|appos|START_ENTITY ligand|amod|END_ENTITY	Effect of circulating soluble receptor for advanced glycation end products -LRB- sRAGE -RRB- and the proinflammatory RAGE ligand -LRB- EN-RAGE , S100A12 -RRB- on mortality in hemodialysis patients .
12832680	0	EN-RAGE	23,30	S100A12	14,21	EN-RAGE	S100A12	6283	6283	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of S100A12 -LRB- EN-RAGE -RRB- in cystic_fibrosis .
12832707	0	EN-RAGE	52,59	S100A12	43,50	EN-RAGE	S100A12	6283	6283	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the pro-inflammatory protein S100A12 -LRB- EN-RAGE -RRB- in rheumatoid_and_psoriatic_arthritis .
15531492	0	EN-RAGE	26,33	S100A12	17,24	EN-RAGE	S100A12	6283	6283	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Increased plasma S100A12 -LRB- EN-RAGE -RRB- levels in patients with type 2 diabetes .
18663285	0	EN-RAGE	26,33	S100A12	17,24	EN-RAGE	S100A12	6283	6283	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Increased plasma S100A12 -LRB- EN-RAGE -RRB- levels in hemodialysis patients with atherosclerosis .
11807898	0	EN1	142,145	EN2	147,150	EN1	EN2	2019	2020	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Search for genes involved in Joubert_syndrome : evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1 , EN2 , FGF8 , and BARHL1 .
11807898	0	EN1	142,145	FGF8	152,156	EN1	FGF8	2019	2253	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Search for genes involved in Joubert_syndrome : evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1 , EN2 , FGF8 , and BARHL1 .
11807898	0	EN2	147,150	EN1	142,145	EN2	EN1	2020	2019	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Search for genes involved in Joubert_syndrome : evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1 , EN2 , FGF8 , and BARHL1 .
17948901	0	EN2	32,35	ENGRAILED_2	19,30	EN2	ENGRAILED 2	13799(Tax:10090)	13799(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the ENGRAILED_2 -LRB- EN2 -RRB- gene with autism in Chinese Han population .
23792811	0	EN2	21,24	Engrailed-2	8,19	EN2	Engrailed-2	2020	2020	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Engrailed-2 -LRB- EN2 -RRB- as a prostate_cancer detection biomarker in genetically high risk men .
24654775	0	EN2	44,47	Engrailed-2	31,42	EN2	Engrailed-2	2020	2020	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Spontaneous antibodies against Engrailed-2 -LRB- EN2 -RRB- protein in patients with prostate_cancer .
11807898	0	EN2	147,150	FGF8	152,156	EN2	FGF8	2020	2253	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Search for genes involved in Joubert_syndrome : evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1 , EN2 , FGF8 , and BARHL1 .
12680872	0	ENA-78	54,60	CXCL5	61,66	ENA-78	CXCL5	6374	6374	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of the neutrophil-activating CXC chemokine ENA-78 / CXCL5 by human eosinophils .
11523797	0	ENA1	97,101	Crz1	79,83	ENA1	Crz1	851610(Tax:4932)	855704(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene .
11691783	0	ENC1	49,53	ectodermal-neural_cortex_1	21,47	ENC1	ectodermal-neural cortex 1	8507	8507	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Up-regulation of the ectodermal-neural_cortex_1 -LRB- ENC1 -RRB- gene , a downstream target of the beta-catenin/T-cell factor complex , in colorectal_carcinomas .
16705692	0	ENG	16,19	ALK1	32,36	ENG	ALK1	2022	94	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of ENG and ACVRL1 -LRB- ALK1 -RRB- mutations in French HHT patients .
17948901	0	ENGRAILED_2	19,30	EN2	32,35	ENGRAILED 2	EN2	13799(Tax:10090)	13799(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the ENGRAILED_2 -LRB- EN2 -RRB- gene with autism in Chinese Han population .
16531493	0	ENHANCED_DISEASE_SUSCEPTIBILITY1	27,59	FMO1	143,147	ENHANCED DISEASE SUSCEPTIBILITY1	FMO1	823964(Tax:3702)	838508(Tax:3702)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Salicylic_acid-independent ENHANCED_DISEASE_SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7 .
26097998	0	ENO1	27,31	FBXW7	0,5	ENO1	FBXW7	2023	55294	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FBXW7 negatively regulates ENO1 expression and function in colorectal_cancer .
18851946	0	ENO1	39,43	Ree1	6,10	ENO1	Ree1	853169(Tax:4932)	853238(Tax:4932)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Novel Ree1 regulates the expression of ENO1 via the Snf1 complex pathway in Saccharomyces_cerevisiae .
19223001	0	ENO1	96,100	enolase	87,94	ENO1	enolase	843741(Tax:3702)	843741(Tax:3702)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular and functional characterization of the plastid-localized Phosphoenolpyruvate enolase -LRB- ENO1 -RRB- from Arabidopsis_thaliana .
21995595	0	ENO2	109,113	neuron-specific_enolase	79,102	ENO2	neuron-specific enolase	2026	2026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparative gene expression profiling analysis of lymphoblastoid cells reveals neuron-specific_enolase gene -LRB- ENO2 -RRB- as a susceptibility gene of heroin_dependence .
2249478	0	ENO2	42,46	neurone-specific_enolase	16,40	ENO2	neurone-specific enolase	2026	2026	Gene	Gene	Localisation|appos|START_ENTITY Localisation|nmod|END_ENTITY	Localisation of neurone-specific_enolase -LRB- ENO2 -RRB- to 12p13 .
1840492	0	ENO3	63,67	muscle-specific_enolase	33,56	ENO3	muscle-specific enolase	2027	2027	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular structure of the human muscle-specific_enolase gene -LRB- ENO3 -RRB- .
22846226	0	ENOX2	129,134	tNOX	123,127	ENOX2	tNOX	10495	10495	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX -LRB- ENOX2 -RRB- protein .
9268642	0	ENPEP	71,76	glutamyl_aminopeptidase	41,64	ENPEP	glutamyl aminopeptidase	2028	2028	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	High-resolution genetic map of the human glutamyl_aminopeptidase gene -LRB- ENPEP -RRB- .
19083193	0	ENPP1	21,26	HSP70	12,17	ENPP1	HSP70	5167	3308	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of HSP70 on ENPP1 expression and insulin-receptor activation .
22402064	0	ENPP1	56,61	ectonucleotide_pyrophosphatase_phosphodiesterase_1	4,54	ENPP1	ectonucleotide pyrophosphatase phosphodiesterase 1	5167	5167	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	The ectonucleotide_pyrophosphatase_phosphodiesterase_1 -LRB- ENPP1 -RRB- K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals .
22262087	0	ENPP1	62,67	somatomedin_B	37,50	ENPP1	somatomedin B	5167	7448	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	In silico analysis of the two tandem somatomedin_B domains of ENPP1 reveals hints on the homodimerization of the protein .
20374202	0	ENT1	0,4	EAAT2	33,38	ENT1	EAAT2	63959(Tax:10090)	20511(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	ENT1 regulates ethanol-sensitive EAAT2 expression and function in astrocytes .
16688763	0	ENT1	43,47	SLC29A1	54,61	ENT1	SLC29A1	2030	2030	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Nitric_oxide reduces adenosine transporter ENT1 gene -LRB- SLC29A1 -RRB- promoter activity in human fetal endothelium from gestational diabetes .
17941087	0	ENT1	78,82	equilibrative_nucleoside_transporter	38,74	ENT1	equilibrative nucleoside transporter	63997(Tax:10116)	63997(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High glucose suppresses expression of equilibrative_nucleoside_transporter 1 -LRB- ENT1 -RRB- in rat cardiac fibroblasts through a mechanism dependent on PKC-zeta and MAP kinases .
19164463	0	ENT1	56,60	equilibrative_nucleoside_transporter_1	16,54	ENT1	equilibrative nucleoside transporter 1	2030	2030	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the equilibrative_nucleoside_transporter_1 -LRB- ENT1 -RRB- in transport and metabolism of ribavirin by human and wild-type or Ent1 - / - mouse erythrocytes .
16616458	0	ENTH	30,34	Epsin_4	36,43	ENTH	Epsin 4	9685	9685	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic analysis of the human ENTH -LRB- Epsin_4 -RRB- gene and schizophrenia .
19308674	0	ENTPD1	65,71	CD39	59,63	ENTPD1	CD39	12495(Tax:10090)	12495(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Vascular smooth muscle cell expression of ectonucleotidase CD39 -LRB- ENTPD1 -RRB- is required for neointimal formation in mice .
23901069	0	ENTPD1	33,39	CD39	27,31	ENTPD1	CD39	953	953	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of ecto-apyrase CD39 -LRB- ENTPD1 -RRB- expression by phosphodiesterase III -LRB- PDE3 -RRB- .
8649418	0	ENX-1	24,29	Vav	15,18	ENX-1	Vav	2146	7409	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Vav with ENX-1 , a putative transcriptional regulator of homeobox gene expression .
12600746	0	ENX-2	27,32	ZAP-70	48,54	ENX-2	ZAP-70	2145	7535	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Polycomb-group protein ENX-2 interacts with ZAP-70 .
2534288	0	ENX2	24,28	endonexin_II	10,22	ENX2	endonexin II	308	308	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human endonexin_II -LRB- ENX2 -RRB- gene is located at 4q28 -- q32 .
15843443	0	ENaC	43,47	SGK1	8,12	ENaC	SGK1	20276(Tax:10090)	20393(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Role of SGK1 in nitric_oxide inhibition of ENaC in Na + - transporting epithelia .
26160150	0	ENaC	55,59	SPAK	0,4	ENaC	SPAK	20276(Tax:10090)	53416(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	SPAK Sensitive Regulation of the Epithelial Na Channel ENaC .
18928407	0	ENaC	45,49	epithelial_sodium_channel	18,43	ENaC	epithelial sodium channel	20276(Tax:10090)	20276(Tax:10090)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of the epithelial_sodium_channel -LRB- ENaC -RRB- by serine proteases .
14556084	0	ENaC	45,49	epithelial_sodium_channels	17,43	ENaC	epithelial sodium channels	24768(Tax:10116)	24768(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Putative role of epithelial_sodium_channels -LRB- ENaC -RRB- in the afferent limb of cardio renal reflexes in rats .
25274815	0	EOL-1	0,5	Dom3Z	36,41	EOL-1	Dom3Z	6418775(Tax:6239)	1797	Gene	Gene	START_ENTITY|appos|Homolog Homolog|nmod|END_ENTITY	EOL-1 , the Homolog of the Mammalian Dom3Z , Regulates Olfactory Learning in C. _ elegans .
12130541	0	EOR-1	11,16	PLZF	17,21	EOR-1	PLZF	177249(Tax:6239)	7704	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	C. _ elegans EOR-1 / PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component .
12921570	0	EP-CAM	15,21	beta-catenin	23,35	EP-CAM	beta-catenin	4072	1499	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of EP-CAM , beta-catenin in the carcinogenesis of squamous_cell_carcinoma_of_uterine_cervix -RSB- .
10585755	0	EP-CAM	65,71	epithelial_cell_adhesion_molecule	30,63	EP-CAM	epithelial cell adhesion molecule	17075(Tax:10090)	17075(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abnormal thymic expression of epithelial_cell_adhesion_molecule -LRB- EP-CAM -RRB- in New Zealand Black -LRB- NZB -RRB- mice .
18648368	0	EP1	58,61	Fas_ligand	28,38	EP1	Fas ligand	5731	356	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor END_ENTITY|dobj|expression	Prostaglandin_E2 stimulates Fas_ligand expression via the EP1 receptor in colon_cancer cells .
19277991	0	EP1	37,40	HIF-1alpha	0,10	EP1	HIF-1alpha	5731	3091	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HIF-1alpha regulates hypoxia-induced EP1 expression in osteoblastic cells .
15855163	0	EP1	109,112	epidermal_growth_factor_receptor	149,181	EP1	epidermal growth factor receptor	5731	1956	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin_E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
26188043	0	EP1	109,112	epidermal_growth_factor_receptor	149,181	EP1	epidermal growth factor receptor	5731	1956	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
26188043	0	EP1	109,112	epidermal_growth_factor_receptor	149,181	EP1	epidermal growth factor receptor	5731	1956	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
9352015	0	EP1	96,99	interleukin-1_beta	14,32	EP1	interleukin-1 beta	5731	3553	Gene	Gene	expression|nmod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	The effect of interleukin-1_beta and interleukin-4 on the expression of prostaglandin receptors EP1 and EP3 in amnion WISH cells .
24626807	0	EP2	28,31	Snail	41,46	EP2	Snail	19217(Tax:10090)	20613(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E receptor EP2 mediates Snail expression in hepatocellular_carcinoma cells .
19897661	0	EP2	14,17	TGF-beta	63,71	EP2	TGF-beta	19217(Tax:10090)	21803(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis .
20347274	0	EP2	127,130	Wnt3a	168,173	EP2	Wnt3a	5732	89780	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Identification of transcriptional targets of Wnt/beta-catenin signaling in dermal papilla cells of human scalp hair follicles : EP2 is a novel transcriptional target of Wnt3a .
26535079	0	EP2	0,3	p38	12,15	EP2	p38	19217(Tax:10090)	26416(Tax:10090)	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells .
18537828	0	EP2	131,134	protease-activated_receptor-1	18,47	EP2	protease-activated receptor-1	5732	2149	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of protease-activated_receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A .
23708855	0	EP2_receptor	29,41	TMPRSS4	94,101	EP2 receptor	TMPRSS4	19217(Tax:10090)	214523(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of soluble EP2_receptor on ovarian_tumor growth in nude_mice and utility of TMPRSS4 as a combinatorial molecular target .
23272250	0	EP300	4,9	KLF4	70,74	EP300	KLF4	328572(Tax:10090)	16600(Tax:10090)	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	The EP300 , KDM5A , KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1 .
15123663	0	EP4	64,67	ERK	84,87	EP4	ERK	19219(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Colon_carcinoma cell growth is associated with prostaglandin_E2 / EP4 receptor-evoked ERK activation .
25917098	0	EP4	64,67	NLRP3	26,31	EP4	NLRP3	5734	114548	Gene	Gene	Receptor|compound|START_ENTITY Activation|nmod|Receptor Activation|compound|END_ENTITY	Prostaglandin_E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic_AMP in Human Macrophages .
23998949	0	EP4	10,13	PGC-1a	140,146	EP4	PGC-1a	5734	10891	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling : the role of PGC-1a and Sp1 .
21205091	0	EP4	92,95	epidermal_growth_factor_receptor	14,46	EP4	epidermal growth factor receptor	19219(Tax:10090)	13649(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of epidermal_growth_factor_receptor signaling by the prostaglandin_E -LRB- 2 -RRB- receptor EP4 pathway during gastric tumorigenesis .
25733698	0	EP4	54,57	miR-526b	25,33	EP4	miR-526b	5734	574468	Gene	Gene	Activation|compound|START_ENTITY END_ENTITY|nmod|Activation	COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation .
14634592	0	EP4	71,74	prostaglandin_E2_receptor_type_4	37,69	EP4	prostaglandin E2 receptor type 4	84023(Tax:10116)	84023(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of the rat prostaglandin_E2_receptor_type_4 -LRB- EP4 -RRB- in pregnant cervical tissue .
22199300	0	EP4	27,30	snail	45,50	EP4	snail	19219(Tax:10090)	20613(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|signaling signaling|compound|END_ENTITY	Modulation of PGE2-induced EP4 expression on snail signaling and the impact on epithelial-mesenchymal transition : significance of EP4 antagonism .
24378569	0	EPAC	54,58	Rap-1	60,65	EPAC	Rap-1	10411	5906	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Targeting endothelial junctional adhesion molecule-A / EPAC / Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic_muscles .
26840743	0	EPAC2	86,91	XIAP	47,51	EPAC2	XIAP	252857(Tax:10116)	63879(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|dep|Role	Urocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery : Role of EPAC2 and ERK1/2 .
25192290	0	EPAS-1	0,6	FBI-1	31,36	EPAS-1	FBI-1	2034	51341	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation .
12670588	0	EPAS-1	49,55	HIF-2alpha	56,66	EPAS-1	HIF-2alpha	2034	2034	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Correlation study showing no concordance between EPAS-1 / HIF-2alpha mRNA and protein expression in transitional cellcancer of the bladder .
11992927	0	EPAS1	34,39	HIF-2alpha	23,33	EPAS1	HIF-2alpha	2034	2034	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Positive expression of HIF-2alpha / EPAS1 in invasive bladder_cancer .
14966910	0	EPAS1	25,30	HIF-2alpha	14,24	EPAS1	HIF-2alpha	2034	2034	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of HIF-2alpha / EPAS1 in hepatocellular_carcinoma .
23418310	0	EPAS1	8,13	HIF2A	15,20	EPAS1	HIF2A	2034	2034	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Tumoral EPAS1 -LRB- HIF2A -RRB- mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis .
12099714	0	EPAS1	109,114	adrenomedullin	49,63	EPAS1	adrenomedullin	2034	133	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Endothelial_PAS_domain_protein_1 -LRB- EPAS1 -RRB- induces adrenomedullin gene expression in cardiac myocytes : role of EPAS1 in an inflammatory response in cardiac myocytes .
21628394	0	EPB41L3	88,95	miRNA-223	0,9	EPB41L3	miRNA-223	23136	407008	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miRNA-223 promotes gastric_cancer invasion and metastasis by targeting tumor suppressor EPB41L3 .
15138999	0	EPB41L3	58,65	tumor-suppressor	67,83	EPB41L3	tumor-suppressor	23136	7248	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allele-specific loss of heterozygosity at the DAL-1 / 4.1 B -LRB- EPB41L3 -RRB- tumor-suppressor gene locus in the absence of mutation .
12599204	0	EPC-1	18,23	PEDF	24,28	EPC-1	PEDF	80314	5176	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Putative role for EPC-1 / PEDF in the G0 growth_arrest of human diploid fibroblasts .
15140209	0	EPC-1	8,13	PEDF	14,18	EPC-1	PEDF	80314	5176	Gene	Gene	Loss|nmod|START_ENTITY Loss|dep|expression expression|amod|END_ENTITY	Loss of EPC-1 / PEDF expression during skin aging in vivo .
25060911	0	EPCAM	66,71	epithelial_cell_adhesion_molecule	31,64	EPCAM	epithelial cell adhesion molecule	4072	4072	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Clinical significance of serum epithelial_cell_adhesion_molecule -LRB- EPCAM -RRB- levels in patients with lung_cancer .
11246560	0	EPCR	82,86	endothelial_cell_protein_C_receptor	45,80	EPCR	endothelial cell protein C receptor	10544	10544	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Expression and anticoagulant function of the endothelial_cell_protein_C_receptor -LRB- EPCR -RRB- in cancer cell lines .
11686350	0	EPCR	56,60	endothelial_protein_C_receptor	24,54	EPCR	endothelial protein C receptor	10544	10544	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A 23bp insertion in the endothelial_protein_C_receptor -LRB- EPCR -RRB- gene impairs EPCR function .
16113830	0	EPCR	90,94	endothelial_protein_C_receptor	58,88	EPCR	endothelial protein C receptor	10544	10544	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial_protein_C_receptor -LRB- EPCR -RRB- gene on the risk of venous_thromboembolism in carriers of factor_V_Leiden .
26620701	0	EPCR	50,54	endothelial_protein_C_receptor	18,48	EPCR	endothelial protein C receptor	10544	10544	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Haplotypes of the endothelial_protein_C_receptor -LRB- EPCR -RRB- gene are not associated with severe malaria in Tanzania .
11410402	0	EPF	80,83	early_pregnancy_factor	56,78	EPF	early pregnancy factor	3336	3336	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Isolation , purification and partial characterization of early_pregnancy_factor -LRB- EPF -RRB- from sera of pregnant women .
2409862	0	EPF	67,70	early_pregnancy_factor	43,65	EPF	early pregnancy factor	3336	3336	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Use of a modified test system to determine early_pregnancy_factor -LRB- EPF -RRB- levels in patients with normal first trimester pregnancy and after therapeutic abortion .
22885670	0	EPG-9	30,35	Atg13	66,71	EPG-9	Atg13	177040(Tax:6239)	176150(Tax:6239)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The C. _ elegans ATG101 homolog EPG-9 directly interacts with EPG-1 / Atg13 and is essential for autophagy .
25963923	0	EPHA2	29,34	EGFR	91,95	EPHA2	EGFR	1969	1956	Gene	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition .
26744526	0	EPHA2	0,5	EGFR	48,52	EPHA2	EGFR	1969	1956	Gene	Gene	Overcomes|compound|START_ENTITY Acquired|nsubj|Overcomes Acquired|nmod|Inhibitors Inhibitors|compound|END_ENTITY	EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung_Cancer .
21737611	0	EPHA2	93,98	EPHB6	70,75	EPHA2	EPHB6	1969	2051	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	A paradigm shift in EPH receptor interaction : biological relevance of EPHB6 interaction with EPHA2 and EPHB2 in breast_carcinoma cell lines .
26833123	0	EPHA2	14,19	Ephrin-A1	4,13	EPHA2	Ephrin-A1	1969	1942	Gene	Gene	Metabolism|compound|START_ENTITY END_ENTITY|dep|Metabolism	The Ephrin-A1 / EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast_Cancer .
19621336	0	EPHB2	40,45	c-Rel	0,5	EPHB2	c-Rel	2048	5966	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	c-Rel is a transcriptional repressor of EPHB2 in colorectal_cancer .
24837431	0	EPHB4	19,24	RASA1	0,5	EPHB4	RASA1	2050	5921	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity .
26073592	0	EPHB4	6,11	Receptor_Tyrosine_Kinase	12,36	EPHB4	Receptor Tyrosine Kinase	2050	5979	Gene	Gene	Mutations|compound|START_ENTITY Mutations|compound|END_ENTITY	Novel EPHB4 Receptor_Tyrosine_Kinase Mutations and Kinomic Pathway Analysis in Lung_Cancer .
21737611	0	EPHB6	70,75	EPHA2	93,98	EPHB6	EPHA2	2051	1969	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	A paradigm shift in EPH receptor interaction : biological relevance of EPHB6 interaction with EPHA2 and EPHB2 in breast_carcinoma cell lines .
24084344	0	EPHX1	126,131	CYP1A1	110,116	EPHX1	CYP1A1	2052	1543	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
24084344	0	EPHX1	126,131	CYP1B1	118,124	EPHX1	CYP1B1	2052	1545	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
23949201	0	EPHX1	70,75	CYP2E1	62,68	EPHX1	CYP2E1	2052	1571	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Dietary aflatoxin_B1 intake , genetic polymorphisms of CYP1A2 , CYP2E1 , EPHX1 , GSTM1 , and GSTT1 , and gastric_cancer risk in Korean .
19657367	0	EPHX1	25,30	DKK-1	66,71	EPHX1	DKK-1	2052	22943	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Genetic polymorphisms of EPHX1 , Gsk3beta , TNFSF8 and myeloma cell DKK-1 expression linked to bone_disease in myeloma .
24084344	0	EPHX1	126,131	GSTM1	133,138	EPHX1	GSTM1	2052	2944	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
21309732	0	EPHX1	15,20	GSTP1	22,27	EPHX1	GSTP1	2052	2950	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Correlation of EPHX1 , GSTP1 , GSTM1 , and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic_obstructive_pulmonary_disease .
14984931	0	EPHX1	55,60	microsomal_epoxide_hydrolase	20,48	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- expression by the transcription factor GATA-4 .
15150264	0	EPHX1	122,127	microsomal_epoxide_hydrolase	87,115	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	CCAAT/enhancer-binding _ protein_alpha -LRB- C/EBPalpha -RRB- activates transcription of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- through the interaction with DNA-bound NF-Y .
15465926	0	EPHX1	116,121	microsomal_epoxide_hydrolase	81,109	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Alternative promoters determine tissue-specific expression profiles of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- .
15716486	0	EPHX1	146,151	microsomal_epoxide_hydrolase	111,139	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variability in human sensitivity to 1,3-butadiene : influence of polymorphisms in the 5 ' - flanking region of the microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- .
23714182	0	EPHX1	62,67	microsomal_epoxide_hydrolase	27,55	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcription of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- is regulated by an HNF-4a / CAR/RXR/PSF complex .
24315822	0	EPHX1	103,108	microsomal_epoxide_hydrolase	73,101	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal_epoxide_hydrolase -LRB- EPHX1 -RRB- through interaction with the E1b far upstream promoter .
24704207	0	EPHX1	108,113	microsomal_epoxide_hydrolase	73,101	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- through a far upstream alternative promoter .
7835893	0	EPHX1	45,50	microsomal_epoxide_hydrolase	10,38	EPHX1	microsomal epoxide hydrolase	2052	2052	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- : complete nucleotide sequence and structural characterization .
10806352	0	EPLIN	30,35	Epithelial_Protein_Lost_in_Neoplasm	37,72	EPLIN	Epithelial Protein Lost in Neoplasm	51474	51474	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the human EPLIN -LRB- Epithelial_Protein_Lost_in_Neoplasm -RRB- gene reveals distinct promoters for the two EPLIN isoforms .
10441345	0	EPM1	135,139	cystatin_B	116,126	EPM1	cystatin B	1476	1476	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Altered spacing of promoter elements due to the dodecamer repeat expansion contributes to reduced expression of the cystatin_B gene in EPM1 .
9192856	0	EPM1	125,129	cystatin_B	98,108	EPM1	cystatin B	1476	1476	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The NNP-1 gene -LRB- D21S2056E -RRB- , which encodes a novel nuclear protein , maps in close proximity to the cystatin_B gene within the EPM1 and APECED critical region on 21q22 .3 .
11396976	0	EPO	47,50	EPO	7,10	EPO	EPO	100008786(Tax:9986)	100008786(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Rabbit EPO gene and cDNA : expression of rabbit EPO after intramuscular injection of pDNA .
11396976	0	EPO	7,10	EPO	47,50	EPO	EPO	100008786(Tax:9986)	100008786(Tax:9986)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Rabbit EPO gene and cDNA : expression of rabbit EPO after intramuscular injection of pDNA .
7993659	0	EPO	16,19	Erythropoietin	0,14	EPO	Erythropoietin	24335(Tax:10116)	24335(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Erythropoietin -LRB- EPO -RRB- levels in fetal rats after ritodrine and terbutaline administration .
10613592	0	EPO	93,96	G-CSF	141,146	EPO	G-CSF	2056	1440	Gene	Gene	erythropoietin|appos|START_ENTITY erythropoietin|appos|END_ENTITY	The increase of the rate of hemopoietic recovery and clinical benefit of the erythropoietin -LRB- EPO -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- with peripheral blood progenitor cells -LRB- PBPC -RRB- after intensive cyclic chemotherapy in high-risk breast_cancer patients .
15972155	0	EPO	49,52	G-CSF	29,34	EPO	G-CSF	2056	1440	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of recombinant human G-CSF combined with EPO in treatment of patients with MDS -RSB- .
18806833	0	EPO	0,3	G-CSF	24,29	EPO	G-CSF	2056	1440	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	EPO in combination with G-CSF improves mobilization effectiveness after chemotherapy with ifosfamide , epirubicin and etoposide and reduces costs during mobilization and transplantation of autologous hematopoietic progenitor cells .
7687308	0	EPO	92,95	G-CSF	65,70	EPO	G-CSF	2056	1440	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	-LSB- Combination therapy with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and erythropoietin -LRB- EPO -RRB- induced prominent granulocyte increase in an elderly case of myelodysplastic_syndrome -LRB- MDS -RRB- -RSB- .
10215450	0	EPO	57,60	ILGF-1	96,102	EPO	ILGF-1	2056	3479	Gene	Gene	erythropoietin|appos|START_ENTITY erythropoietin|appos|END_ENTITY	The relationship between serum levels of erythropoietin -LRB- EPO -RRB- and insulin-like_growth_factor-1 -LRB- ILGF-1 -RRB- and hematocrit -LRB- HCT -RRB- in breast_cancer patients receiving non-nephrotoxic chemotherapy .
8327369	0	EPO	72,75	PTH	102,105	EPO	PTH	2056	5741	Gene	Gene	erythropoietin|appos|START_ENTITY erythropoietin|appos|END_ENTITY	-LSB- Effect of immunosuppression method on levels of plasma erythropoietin -LRB- EPO -RRB- and parathyroid_hormone -LRB- PTH -RRB- during acute_graft_rejection in kidney transplantation -LRB- KTP -RRB- -RSB- .
22808010	0	EPO	111,114	Tnfr-sf13c	77,87	EPO	Tnfr-sf13c	2056	115650	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	Defining an EPOR - regulated transcriptome for primary progenitors , including Tnfr-sf13c as a novel mediator of EPO - dependent erythroblast formation .
10850854	0	EPO	110,113	eosinophil_peroxidase	87,108	EPO	eosinophil peroxidase	303414(Tax:10116)	303414(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil_peroxidase -LRB- EPO -RRB- levels following either systemic or intratracheal administration in sephadex - or ovalbumin-induced inflammatory models .
9188923	0	EPO	29,32	eosinophil_peroxidase	6,27	EPO	eosinophil peroxidase	8288	8288	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Serum eosinophil_peroxidase -LRB- EPO -RRB- levels in asthmatic patients .
11798762	0	EPO	57,60	erythropoietin	41,55	EPO	erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	-LSB- The effects of electroporation-mediated erythropoietin -LRB- EPO -RRB- gene transfer into skeleton muscle on renal_anemia -RSB- .
12068800	0	EPO	22,25	erythropoietin	6,20	EPO	erythropoietin	2056	2056	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum erythropoietin -LRB- EPO -RRB- levels correlate with survival and independently predict response to EPO treatment in patients with myelodysplastic_syndromes .
15672835	0	EPO	40,43	erythropoietin	24,38	EPO	erythropoietin	2056	2056	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of human erythropoietin -LRB- EPO -RRB- affects plant morphologies : retarded vegetative growth in tobacco and male sterility in tobacco and Arabidopsis .
20410932	0	EPO	38,41	erythropoietin	22,36	EPO	erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Therapeutic levels of erythropoietin -LRB- EPO -RRB- achieved after gene electrotransfer to skin in mice .
8139531	0	EPO	36,39	erythropoietin	20,34	EPO	erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	A dominant negative erythropoietin -LRB- EPO -RRB- receptor inhibits EPO-dependent growth and blocks F-gp55-dependent transformation .
8634300	0	EPO	64,67	erythropoietin	48,62	EPO	erythropoietin	2056	2056	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Dimerization of the extracellular domain of the erythropoietin -LRB- EPO -RRB- receptor by EPO : one high-affinity and one low-affinity interaction .
8634300	0	EPO	81,84	erythropoietin	48,62	EPO	erythropoietin	2056	2056	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Dimerization of the extracellular domain of the erythropoietin -LRB- EPO -RRB- receptor by EPO : one high-affinity and one low-affinity interaction .
18495932	0	EPO-R	53,58	erythropoietin_receptor	28,51	EPO-R	erythropoietin receptor	2057	2057	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Synergistic upregulation of erythropoietin_receptor -LRB- EPO-R -RRB- expression by sense and antisense EPO-R transcripts in the canine lung .
17161437	0	EPO-receptor	22,34	Erythropoietin	0,14	EPO-receptor	Erythropoietin	13857(Tax:10090)	13856(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|dep|signaling	Erythropoietin -LRB- EPO -RRB- : EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing .
1962754	0	EPOR	43,47	erythropoietin_receptor	18,41	EPOR	erythropoietin receptor	13857(Tax:10090)	13857(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the erythropoietin_receptor -LRB- EPOR -RRB- gene to mouse chromosome 9 and human chromosome 19 .
23821361	0	EPO_receptor	105,117	Erythropoietin	0,14	EPO receptor	Erythropoietin	24336(Tax:10116)	24335(Tax:10116)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Erythropoietin -LRB- EPO -RRB- increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO_receptor .
22075473	0	EPPIN	41,46	semenogelin	52,63	EPPIN	semenogelin	57119	6406	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Loss of calcium in human spermatozoa via EPPIN , the semenogelin receptor .
20351091	0	EPS8	0,4	FOXM1	17,22	EPS8	FOXM1	2059	2305	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	EPS8 upregulates FOXM1 expression , enhancing cell growth and motility .
23814048	0	ER	68,70	AP1	99,102	ER	AP1	2099	3725	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
26079946	0	ER	165,167	EGFR	105,109	ER	EGFR	2099	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal_growth_factor_receptor -LRB- EGFR -RRB- by disrupting its interaction with estrogen_receptor -LRB- ER -RRB- .
19569049	0	ER	65,67	KLF5	37,41	ER	KLF5	2099	688	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Estrogen-induced interaction between KLF5 and estrogen_receptor -LRB- ER -RRB- suppresses the function of ER in ER-positive breast_cancer cells .
10598586	0	ER	43,45	NCoR	81,85	ER	NCoR	2099	9611	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	A fusion protein of the estrogen_receptor -LRB- ER -RRB- and nuclear_receptor_corepressor -LRB- NCoR -RRB- strongly inhibits estrogen-dependent responses in breast_cancer cells .
26351488	0	ER	15,17	Neu	32,35	ER	Neu	2099	2064	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|END_ENTITY	Correlation of ER , PR and HER-2 / Neu with other Prognostic Factors in Infiltrating Ductal_Carcinoma of Breast .
23578537	0	ER	86,88	Trefoil_factor_family_3	0,23	ER	Trefoil factor family 3	2099	7033	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Trefoil_factor_family_3 -LRB- TFF3 -RRB- expression and its interaction with estrogen_receptor -LRB- ER -RRB- in endometrial_adenocarcinoma .
11082977	0	ER	151,153	VDR	123,126	ER	VDR	2099	7421	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	-LSB- The influence of hormone replacement therapy -LRB- HRT -RRB- on bone density in menopausal women in relation to vitamin_D receptor -LRB- VDR -RRB- and estrogen_receptor -LRB- ER -RRB- -RSB- .
15552843	0	ER	164,166	VDR	136,139	ER	VDR	2099	7421	Gene	Gene	vitamin_D_receptor|appos|START_ENTITY vitamin_D_receptor|appos|END_ENTITY	-LSB- The influence of hormonal replacement therapy on bone density in postmenopausal women depending on polymorphism of vitamin_D_receptor -LRB- VDR -RRB- and estrogen_receptor -LRB- ER -RRB- genes -RSB- .
9204213	0	ER	165,167	estradiol_receptor	145,163	ER	estradiol receptor	2099	2099	Gene	Gene	status|appos|START_ENTITY status|compound|END_ENTITY	Prognostic significance of c-erbB-2 / neu amplification and epidermal_growth_factor_receptor -LRB- EGFR -RRB- in primary breast_cancer and their relation to estradiol_receptor -LRB- ER -RRB- status .
20569503	0	ER	108,110	estrogen-receptor	89,106	ER	estrogen-receptor	2099	2099	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor -LRB- ER -RRB- levels and activity in ER + breast_cancer .
11006500	0	ER	33,35	estrogen_receptor	14,31	ER	estrogen receptor	2099	2099	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of estrogen_receptor -LRB- ER -RRB- in oral mucosa and salivary glands .
11051252	0	ER	27,29	estrogen_receptor	8,25	ER	estrogen receptor	2099	2099	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Loss of estrogen_receptor -LRB- ER -RRB- expression in endometrial_tumors is not associated with de novo methylation of the 5 ' end of the ER gene .
11212261	0	ER	33,35	estrogen_receptor	14,31	ER	estrogen receptor	2099	2099	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of estrogen_receptor -LRB- ER -RRB- subtypes and ERbeta isoforms in colon_cancer .
1371912	0	ER	33,35	estrogen_receptor	14,31	ER	estrogen receptor	2099	2099	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Detection of estrogen_receptor -LRB- ER -RRB- mRNA by use of reverse transcriptase-polymerase chain reaction -LRB- RT-PCR -RRB- assay ; comparison with dextran coated charcoal -LRB- DCC -RRB- assay and immunocytochemical assay -RSB- .
17649823	0	ER	42,44	estrogen_receptor	23,40	ER	estrogen receptor	2099	2099	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms of human estrogen_receptor -LRB- ER -RRB- gene alpha and beta in prostate_cancer PC-EW and PC-OR cell lines .
17683929	0	ER	33,35	estrogen_receptor	14,31	ER	estrogen receptor	2099	2099	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Regulation of estrogen_receptor -LRB- ER -RRB- levels in MCF-7 cells by progesterone metabolites .
20143189	0	ER	282,284	estrogen_receptor	263,280	ER	estrogen receptor	2099	2099	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Breast density , scintimammographic -LRB- 99m -RRB- Tc -LRB- V -RRB- DMSA uptake , and calcitonin_gene_related_peptide -LRB- CGRP -RRB- expression in mixed invasive ductal associated with extensive in __ situ_ductal_carcinoma -LRB- IDC + DCIS -RRB- and pure_invasive_ductal_carcinoma -LRB- IDC -RRB- : correlation with estrogen_receptor -LRB- ER -RRB- status , proliferation index Ki-67 , and histological grade .
2097642	0	ER	55,57	estrogen_receptor	36,53	ER	estrogen receptor	2099	2099	Gene	Gene	status|appos|START_ENTITY status|appos|END_ENTITY	Correlations among receptor status , estrogen_receptor -LRB- ER -RRB- form -LRB- 8S and/or 4S -RRB- and labelling index -LRB- LI -RRB- in human breast cancer .
25614118	0	ER	80,82	estrogen_receptor	61,78	ER	estrogen receptor	2099	2099	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Structure-activity relationship study of diphenylamine-based estrogen_receptor -LRB- ER -RRB- antagonists .
4092577	0	ER	86,88	estrogen_receptor	67,84	ER	estrogen receptor	2099	2099	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	-LSB- The influence and significance of obtaining , storing and assay on estrogen_receptor -LRB- ER -RRB- content in breast_cancer tissue -RSB- .
8702313	0	ER	46,48	estrogen_receptor	27,44	ER	estrogen receptor	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Molecular analysis of the estrogen_receptor -LRB- ER -RRB- gene in association with ER negativity in breast_cancer -RSB- .
8919544	0	ER	77,79	estrogen_receptor	51,68	ER	estrogen receptor	2099	2099	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Sequence analysis of the DNA binding domain of the estrogen_receptor gene in ER -LRB- + -RRB- / PR -LRB- - -RRB- breast_cancer .
8973592	0	ER	44,46	estrogen_receptor	25,42	ER	estrogen receptor	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence variants of the estrogen_receptor -LRB- ER -RRB- gene found in breast_cancer patients with ER negative and progesterone_receptor positive tumors .
9278400	0	ER-60_protease	55,69	Apolipoprotein_B	0,16	ER-60 protease	Apolipoprotein B	29468(Tax:10116)	54225(Tax:10116)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Apolipoprotein_B is intracellularly associated with an ER-60_protease homologue in HepG2 cells .
22461216	0	ER-a	57,61	estrogen_receptor	38,55	ER-a	estrogen receptor	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of osteoprotegerin -LRB- OPG -RRB- and estrogen_receptor -LRB- ER-a -RRB- gene polymorphisms in rheumatoid_arthritis .
15254667	0	ER-alpha	64,72	GLUT-1	34,40	ER-alpha	GLUT-1	2099	6513	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of glucose transporter GLUT-1 and estrogen receptors ER-alpha and ER-beta in human breast_cancer .
15460409	0	ER-alpha	1,9	IGF-1R	11,17	ER-alpha	IGF-1R	24890(Tax:10116)	25718(Tax:10116)	Gene	Gene	START_ENTITY|appos|expressions expressions|compound|END_ENTITY	-LSB- ER-alpha , IGF-1R expressions and co-expressions in newborn rats with experimental hypoxic-ischemic_brain_damage -RSB- .
16033082	0	ER-alpha	94,102	PR	165,167	ER-alpha	PR	2099	5241	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha -LRB- ER-alpha -RRB- , estrogen receptor beta -LRB- ER-beta -RRB- and progesterone_receptor -LRB- PR -RRB- .
15532726	0	ER-alpha	99,107	VEGF-A	27,33	ER-alpha	VEGF-A	2099	7422	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Differential expression of VEGF-A mRNA by 17beta-estradiol in breast_tumor cells lacking classical ER-alpha may be mediated through a variant form of ER-alpha .
11752866	0	ER-alpha	33,41	estrogen_receptor	14,31	ER-alpha	estrogen receptor	2099	2099	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of estrogen_receptor -LRB- ER-alpha and ER-beta -RRB- mRNA in human prostate_cancer .
19661335	0	ER-alpha	68,76	estrogen_receptor-alpha	43,66	ER-alpha	estrogen receptor-alpha	2099	2099	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
18839613	0	ER-alpha	42,50	estrogen_receptor_alpha	17,40	ER-alpha	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- The analysis of estrogen_receptor_alpha -LRB- ER-alpha -RRB- gene Pvull and Xbal polymorphisms in postmenopausal women with breast_cancer -RSB- .
23471663	0	ER-b	57,61	MMP-2	38,43	ER-b	MMP-2	13983(Tax:10090)	17390(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Raloxifene upregulated mesangial cell MMP-2 activity via ER-b through transcriptional regulation .
10982847	0	ER81	44,48	CREB-binding_protein	84,104	ER81	CREB-binding protein	2115	1387	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|amod|END_ENTITY	Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding_protein and p300 .
26966528	0	ERAP-1	59,65	Familial_Mediterranean_Fever	72,100	ERAP-1	Familial Mediterranean Fever	51752	4210	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association of endoplasmic_reticulum_aminopeptidase-1 -LRB- ERAP-1 -RRB- with Familial_Mediterranean_Fever -LRB- FMF -RRB- .
26966528	0	ERAP-1	59,65	endoplasmic_reticulum_aminopeptidase-1	19,57	ERAP-1	endoplasmic reticulum aminopeptidase-1	51752	51752	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association of endoplasmic_reticulum_aminopeptidase-1 -LRB- ERAP-1 -RRB- with Familial_Mediterranean_Fever -LRB- FMF -RRB- .
19877036	0	ERAP1	15,20	IL23R	30,35	ERAP1	IL23R	51752	149233	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of ERAP1 , but not IL23R , with ankylosing_spondylitis in a Han Chinese population .
26884329	0	ERAS	47,51	embryonic_stem_cell-expressed_RAS	12,45	ERAS	embryonic stem cell-expressed RAS	3266	3266	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of embryonic_stem_cell-expressed_RAS -LRB- ERAS -RRB- in the maintenance of quiescent hepatic stellate cells .
20076856	0	ERB	52,55	CXCR4	14,19	ERB	CXCR4	2100	7852	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CXCR4 , VLA-1 , LFA-3 and transducer of ERB in G-CSF-mobilised progenitor cells in acute myocardial_infarction .
11522832	0	ERB1	0,4	Bop1	37,41	ERB1	Bop1	855068(Tax:4932)	23246	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	ERB1 , the yeast homolog of mammalian Bop1 , is an essential gene required for maturation of the 25S and 5.8 S ribosomal RNAs .
25336113	0	ERBB	15,19	SOX9	0,4	ERBB	SOX9	1956	6662	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SOX9 regulates ERBB signalling in pancreatic_cancer development .
9162037	0	ERBB-2	18,24	RBPJkappa	37,46	ERBB-2	RBPJkappa	2064	3516	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH .
1675005	0	ERBB2	45,50	HER2	52,56	ERBB2	HER2	2064	2064	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	PCR detection of an MboI polymorphism in the ERBB2 -LRB- HER2 ; NEU -RRB- gene on chromosome 17q11.2-q12 .
23313108	0	ERBB2	16,21	HER2	10,14	ERBB2	HER2	2064	2064	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Change in HER2 -LRB- ERBB2 -RRB- gene status after taxane-based chemotherapy for breast_cancer : polyploidization can lead to diagnostic pitfalls with potential impact for clinical management .
23575477	0	ERBB2	106,111	HER2	100,104	ERBB2	HER2	2064	2064	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relapsed classic E-cadherin -LRB- CDH1 -RRB- - mutated invasive lobular_breast_cancer shows a high frequency of HER2 -LRB- ERBB2 -RRB- gene mutations .
23421821	0	ERBB2	36,41	MBP-1	50,55	ERBB2	MBP-1	2064	2023	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	Negative transcriptional control of ERBB2 gene by MBP-1 and HDAC1 : diagnostic implications in breast_cancer .
24309211	0	ERBB2	27,32	neuregulin_1	78,90	ERBB2	neuregulin 1	2064	3084	Gene	Gene	START_ENTITY|nmod|signalling signalling|amod|END_ENTITY	Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin_1 type III signalling .
8105469	0	ERBB2	28,33	tumor_necrosis_factor_alpha	75,102	ERBB2	tumor necrosis factor alpha	2064	7124	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Inverse regulation of human ERBB2 and epidermal_growth_factor_receptors by tumor_necrosis_factor_alpha .
24685132	0	ERBB3	113,118	KRAS	42,46	ERBB3	KRAS	2065	3845	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon_cancer through transcriptional induction of ERBB3 .
23554686	0	ERBB3	44,49	MiR-148a	0,8	ERBB3	MiR-148a	2065	406940	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-148a inhibits angiogenesis by targeting ERBB3 .
23110497	0	ERBB3_binding_protein_1	14,37	EBP1	39,43	ERBB3 binding protein 1	EBP1	5036	5036	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ERBB3_binding_protein_1 -LRB- EBP1 -RRB- in salivary adenoid_cystic_carcinoma and its clinicopathological relevance .
12954715	0	ERBB4	92,97	STAT5	125,130	ERBB4	STAT5	13869(Tax:10090)	20850(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5 .
25492965	0	ERBB4	23,28	YAP	44,47	ERBB4	YAP	2066	10413	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Neuregulin_1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration .
11278603	0	ERBIN	54,59	PSD-95	70,76	ERBIN	PSD-95	55914	1742	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95 / DLG/ZO -1 domain proteins .
26085855	0	ERCC-1	111,117	Excision_Repair_Cross-Complementation_Group_1	64,109	ERCC-1	Excision Repair Cross-Complementation Group 1	2067	2067	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Correlation Analysis and Prognostic Impact of -LRB- 18 -RRB- F-FDG PET and Excision_Repair_Cross-Complementation_Group_1 -LRB- ERCC-1 -RRB- Expression in Non-Small_Cell_Lung_Cancer .
21224630	0	ERCC-1	82,88	excision_repair_complementing-1	49,80	ERCC-1	excision repair complementing-1	2067	2067	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	-LSB- The expression of thymidylate synthase -LRB- TS -RRB- and excision_repair_complementing-1 -LRB- ERCC-1 -RRB- protein in patients with unresectable colorectal_cancer treated with mFOLFOX6 therapy -RSB- .
19683826	0	ERCC1	31,36	BRCA1	38,43	ERCC1	BRCA1	2067	672	Gene	Gene	XRCC1|compound|START_ENTITY XRCC1|appos|END_ENTITY	The prognostic significance of ERCC1 , BRCA1 , XRCC1 , and betaIII-tubulin expression in patients with non-small_cell_lung_cancer treated by platinum - and taxane-based neoadjuvant chemotherapy and surgical resection .
21529986	0	ERCC1	16,21	BRCA1	9,14	ERCC1	BRCA1	2067	672	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Tubulin , BRCA1 , ERCC1 , Abraxas , RAP80 mRNA expression , p53/p21 immunohistochemistry and clinical outcome in patients with advanced non_small-cell_lung_cancer receiving first-line platinum-gemcitabine chemotherapy .
24058603	0	ERCC1	27,32	BRCA1	20,25	ERCC1	BRCA1	2067	672	Gene	Gene	TOPOI|appos|START_ENTITY TOPOI|compound|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
15737843	0	ERCC1	27,32	DPD	22,25	ERCC1	DPD	2067	1806	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Downregulation of TS , DPD , ERCC1 , GST-Pi , EGFR , and HER2 gene expression after neoadjuvant three-modality treatment in patients with esophageal_cancer .
20003391	0	ERCC1	7,12	ERCC2	0,5	ERCC1	ERCC2	2067	2068	Gene	Gene	polymorphisms|nummod|START_ENTITY END_ENTITY|appos|polymorphisms	ERCC2 , ERCC1 polymorphisms and haplotypes , cooking oil fume and lung_adenocarcinoma risk in Chinese non-smoking females .
25674148	0	ERCC1	15,20	ERCC2	33,38	ERCC1	ERCC2	2067	2068	Gene	Gene	Association|nmod|START_ENTITY _|nsubj|Association _|dobj|polymorphisms polymorphisms|nummod|END_ENTITY	Association of ERCC1 rs3212986 _ ERCC2 rs13181 polymorphisms with the risk of glioma .
26314858	0	ERCC1	14,19	ERCC2	21,26	ERCC1	ERCC2	2067	2068	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
21091775	0	ERCC1	47,52	Excision_repair_cross-complementation_group_1	0,45	ERCC1	Excision repair cross-complementation group 1	2067	2067	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Excision_repair_cross-complementation_group_1 -LRB- ERCC1 -RRB- expression in advanced urothelial_carcinoma patients receiving cisplatin-based chemotherapy .
26314858	0	ERCC1	14,19	GSTP1	35,40	ERCC1	GSTP1	2067	2950	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
15256455	0	ERCC1	43,48	H-Ras	10,15	ERCC1	H-Ras	2067	3265	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Oncogenic H-Ras up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents .
21529986	0	ERCC1	16,21	RAP80	32,37	ERCC1	RAP80	2067	51720	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Tubulin , BRCA1 , ERCC1 , Abraxas , RAP80 mRNA expression , p53/p21 immunohistochemistry and clinical outcome in patients with advanced non_small-cell_lung_cancer receiving first-line platinum-gemcitabine chemotherapy .
26842788	0	ERCC1	118,123	RRM1	131,135	ERCC1	RRM1	2067	6240	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
26842788	0	ERCC1	118,123	TUBB3	137,142	ERCC1	TUBB3	2067	10381	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
26842788	0	ERCC1	118,123	TYMS	125,129	ERCC1	TYMS	2067	7298	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
16756962	0	ERCC1	107,112	XPA	0,3	ERCC1	XPA	2067	7507	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin_C in prostate_cancer cells : role of ERCC1 in homologous recombination repair .
23746523	0	ERCC1	51,56	XPA	143,146	ERCC1	XPA	2067	7507	Gene	Gene	Pathway|amod|START_ENTITY recruitment|nmod|Pathway determinants|nmod|recruitment determinants|dep|structure structure|nmod|motif motif|compound|END_ENTITY	Conformational determinants for the recruitment of ERCC1 by XPA in the nucleotide excision repair -LRB- NER -RRB- Pathway : structure and dynamics of the XPA binding motif .
7598728	0	ERCC1	74,79	XPA	46,49	ERCC1	XPA	2067	7507	Gene	Gene	protein|compound|START_ENTITY Enhancement|nmod|protein Enhancement|nmod|END_ENTITY	Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein .
7891694	0	ERCC1	47,52	XPA	13,16	ERCC1	XPA	2067	7507	Gene	Gene	prevent|nmod|START_ENTITY END_ENTITY|acl:relcl|prevent	Mutations in XPA that prevent association with ERCC1 are defective in nucleotide excision repair .
22197612	0	ERCC1	89,94	XPG	78,81	ERCC1	XPG	2067	2073	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Trabectedin in patients with advanced non-small-cell_lung_cancer -LRB- NSCLC -RRB- with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum .
26314858	0	ERCC1	14,19	XRCC1	28,33	ERCC1	XRCC1	2067	7515	Gene	Gene	GSTT1|compound|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
21093896	0	ERCC1	0,5	excision_repair_cross-complementation_group_1	7,52	ERCC1	excision repair cross-complementation group 1	2067	2067	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	ERCC1 -LRB- excision_repair_cross-complementation_group_1 -RRB- expression as a predictor for response of neoadjuvant chemotherapy for FIGO stage 2B uterine cervix cancer .
22329847	0	ERCC1	104,109	excision_repair_cross-complementation_group_1	57,102	ERCC1	excision repair cross-complementation group 1	2067	2067	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	F-FDG uptake on PET could be a predictive marker of excision_repair_cross-complementation_group_1 -LRB- ERCC1 -RRB- expression in patients with thoracic_neoplasms ?
26179868	0	ERCC1	86,91	excision_repair_cross-complementation_group_1	39,84	ERCC1	excision repair cross-complementation group 1	2067	2067	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The prognostic and predictive value of excision_repair_cross-complementation_group_1 -LRB- ERCC1 -RRB- protein in 1288 patients with head_and_neck_squamous_cell_carcinoma treated with platinum-based therapy : a meta-analysis .
25083297	0	ERCC1	80,85	excision_repair_cross_complement-1	44,78	ERCC1	excision repair cross complement-1	2067	2067	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Breast_cancer_resistance_protein -LRB- BCRP -RRB- and excision_repair_cross_complement-1 -LRB- ERCC1 -RRB- expression in esophageal_cancers and response to cisplatin and irinotecan based chemotherapy .
20003391	0	ERCC2	0,5	ERCC1	7,12	ERCC2	ERCC1	2068	2067	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|nummod|END_ENTITY	ERCC2 , ERCC1 polymorphisms and haplotypes , cooking oil fume and lung_adenocarcinoma risk in Chinese non-smoking females .
25674148	0	ERCC2	33,38	ERCC1	15,20	ERCC2	ERCC1	2068	2067	Gene	Gene	polymorphisms|nummod|START_ENTITY _|dobj|polymorphisms _|nsubj|Association Association|nmod|END_ENTITY	Association of ERCC1 rs3212986 _ ERCC2 rs13181 polymorphisms with the risk of glioma .
26314858	0	ERCC2	21,26	ERCC1	14,19	ERCC2	ERCC1	2068	2067	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
26314858	0	ERCC2	21,26	GSTP1	35,40	ERCC2	GSTP1	2068	2950	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
18470933	0	ERCC2	84,89	XPD	91,94	ERCC2	XPD	2068	2068	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 -LRB- XPD -RRB- mutations : cancer-prone_xeroderma_pigmentosum vs. non-cancer-prone_trichothiodystrophy .
9111200	0	ERCC2	119,124	XPD	114,117	ERCC2	XPD	100689272	100689272	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Restoration of preferential and strand specific gene repair in group 2 Chinese_hamster ovary mutants -LRB- UV5 -RRB- by the XPD _ -LRB- ERCC2 -RRB- gene .
9238033	0	ERCC2	98,103	XPD	93,96	ERCC2	XPD	2068	2068	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Xeroderma_pigmentosum and trichothiodystrophy are associated with different mutations in the XPD -LRB- ERCC2 -RRB- repair/transcription gene .
26314858	0	ERCC2	21,26	XRCC1	28,33	ERCC2	XRCC1	2068	7515	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
21672525	0	ERCC3	57,62	MiR-192	0,7	ERCC3	MiR-192	2071	406967	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2 .2.15 cells .
12590132	0	ERCC3	62,67	TFIIH	118,123	ERCC3	TFIIH	2071	2071	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH .
16947863	0	ERCC3	55,60	XPB	32,35	ERCC3	XPB	2071	2071	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phenotypic heterogeneity in the XPB DNA helicase gene -LRB- ERCC3 -RRB- : xeroderma_pigmentosum without and with Cockayne_syndrome .
23255472	0	ERCC5	11,16	XPG	6,9	ERCC5	XPG	2073	2073	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Novel XPG -LRB- ERCC5 -RRB- mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress .
8811084	0	ERCC6	15,20	CSB	10,13	ERCC6	CSB	2074	2074	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human CSB -LRB- ERCC6 -RRB- gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61 .
9443879	0	ERCC6	44,49	CSB	39,42	ERCC6	CSB	2074	2074	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular analysis of mutations in the CSB -LRB- ERCC6 -RRB- gene in patients with Cockayne_syndrome .
24645853	0	ERF	63,66	Ethylene_Response_Factor	37,61	ERF	Ethylene Response Factor	606712(Tax:4081)	606712(Tax:4081)	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	The chimeric repressor version of an Ethylene_Response_Factor -LRB- ERF -RRB- family member , Sl-ERF .
9192842	0	ERF	78,81	PE-2	72,76	ERF	PE-2	2077	2077	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Genomic structure and chromosomal localization of the novel ETS factor , PE-2 -LRB- ERF -RRB- .
10887131	0	ERF-1	118,123	TIS11b	110,116	ERF-1	TIS11b	677	677	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of genes under the downstream control of the t -LRB- 8 ; 21 -RRB- fusion protein AML1-MTG8 : overexpression of the TIS11b -LRB- ERF-1 , cMG1 -RRB- gene induces myeloid cell proliferation in response to G-CSF .
25723847	0	ERF3	45,49	Ethylene_response_factor_3	17,43	ERF3	Ethylene response factor 3	102580681	102580681	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	The induction of Ethylene_response_factor_3 -LRB- ERF3 -RRB- in potato as a result of co-inoculation with Pseudomonas sp .
23380710	0	ERG	22,25	AKT	0,3	ERG	AKT	2078	207	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL .
20563261	0	ERG	42,45	CXCR4	28,33	ERG	CXCR4	2078	7852	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate_Cancer Cells .
23086769	0	ERG	29,32	ERG	45,48	ERG	ERG	2078	2078	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Correlation of urine TMPRSS2 : ERG and PCA3 to ERG + and total_prostate_cancer burden .
23086769	0	ERG	45,48	ERG	29,32	ERG	ERG	2078	2078	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Correlation of urine TMPRSS2 : ERG and PCA3 to ERG + and total_prostate_cancer burden .
22922762	0	ERG	0,3	ETS-2	36,41	ERG	ETS-2	2078	2114	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	ERG is specifically associated with ETS-2 and ETV-4 , but not with ETS-1 , in prostate_cancer .
23686669	0	ERG	24,27	ETS-related_gene	29,45	ERG	ETS-related gene	2078	2078	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Prognostic potential of ERG -LRB- ETS-related_gene -RRB- expression in prostatic_adenocarcinoma .
20713528	0	ERG	22,25	FZD4	0,4	ERG	FZD4	2078	8322	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate_cancer cells .
16951139	0	ERG	8,11	TMPRSS2	0,7	ERG	TMPRSS2	2078	7113	Gene	Gene	deletions|compound|START_ENTITY provide|nsubj|deletions END_ENTITY|parataxis|provide	TMPRSS2 : ERG fusion-associated deletions provide insight into the heterogeneity of prostate_cancer .
17108102	0	ERG	8,11	TMPRSS2	0,7	ERG	TMPRSS2	2078	7113	Gene	Gene	fusion|compound|START_ENTITY relevant|nsubj|fusion END_ENTITY|parataxis|relevant	TMPRSS2 : ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate_cancer , but is bypassed in late-stage androgen_receptor-negative prostate_cancer .
17172822	0	ERG	22,25	TMPRSS2	14,21	ERG	TMPRSS2	2078	7113	Gene	Gene	fusion|compound|START_ENTITY END_ENTITY|dep|fusion	Expression of TMPRSS2 : ERG gene fusion in prostate_cancer cells is an important prognostic factor for cancer progression .
17237811	0	ERG	8,11	TMPRSS2	0,7	ERG	TMPRSS2	2078	7113	Gene	Gene	fusion|compound|START_ENTITY END_ENTITY|dep|fusion	TMPRSS2 : ERG gene fusion associated with lethal prostate_cancer in a watchful waiting cohort .
17259299	0	ERG	25,28	TMPRSS2	17,24	ERG	TMPRSS2	2078	7113	Gene	Gene	fusion|compound|START_ENTITY increased|nsubjpass|fusion increased|nmod|END_ENTITY	Frequency of the TMPRSS2 : ERG gene fusion is increased in moderate to poorly differentiated prostate_cancers .
17637754	0	ERG	40,43	TMPRSS2	29,36	ERG	TMPRSS2	2078	7113	Gene	Gene	sequences|compound|START_ENTITY END_ENTITY|nmod|sequences	Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate_cancer .
19494719	0	ERG	41,44	TMPRSS2	33,40	ERG	TMPRSS2	2078	7113	Gene	Gene	gene|compound|START_ENTITY Persistence|dep|gene Persistence|nmod|expression expression|nmod|END_ENTITY	Persistence of expression of the TMPRSS2 : ERG fusion gene after pre-surgery androgen ablation may be associated with early prostate_specific_antigen relapse of prostate_cancer : preliminary results .
20147525	0	ERG	124,127	TMPRSS2	116,123	ERG	TMPRSS2	2078	7113	Gene	Gene	alpha|dep|START_ENTITY alpha|dep|inhibits inhibits|advcl|inducing inducing|dobj|END_ENTITY	1 -LCB- alpha -RCB- ,25 - Dihydroxyvitamin_D3 inhibits growth of VCaP_prostate_cancer cells despite inducing the growth-promoting TMPRSS2 : ERG gene fusion .
21378318	0	ERG	37,40	TMPRSS2	29,36	ERG	TMPRSS2	2078	7113	Gene	Gene	fusion-positive|nsubj|START_ENTITY down-regulated|parataxis|fusion-positive down-regulated|nmod|END_ENTITY	miR-221 Is down-regulated in TMPRSS2 : ERG fusion-positive prostate_cancer .
22076164	0	ERG	35,38	TMPRSS2	26,33	ERG	TMPRSS2	2078	7113	Gene	Gene	marker|nsubj|START_ENTITY END_ENTITY|dep|marker	The oncogenic gene fusion TMPRSS2 : ERG is not a diagnostic or prognostic marker for ovarian_cancer .
22736790	0	ERG	12,15	TMPRSS2	4,11	ERG	TMPRSS2	2078	7113	Gene	Gene	rearrangement|compound|START_ENTITY END_ENTITY|dep|rearrangement	The TMPRSS2 : ERG rearrangement , ERG expression , and prostate_cancer outcomes : a cohort study and meta-analysis .
22860005	0	ERG	16,19	TMPRSS2	0,7	ERG	TMPRSS2	13876(Tax:10090)	50528(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY driven|dobj|expression driven|dep|END_ENTITY	TMPRSS2 - driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation .
23086769	0	ERG	29,32	TMPRSS2	21,28	ERG	TMPRSS2	2078	7113	Gene	Gene	Correlation|dep|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of urine TMPRSS2 : ERG and PCA3 to ERG + and total_prostate_cancer burden .
23086769	0	ERG	45,48	TMPRSS2	21,28	ERG	TMPRSS2	2078	7113	Gene	Gene	+|compound|START_ENTITY ERG|nmod|+ Correlation|dep|ERG Correlation|nmod|END_ENTITY	Correlation of urine TMPRSS2 : ERG and PCA3 to ERG + and total_prostate_cancer burden .
23244085	0	ERG	47,50	TMPRSS2	15,22	ERG	TMPRSS2	2078	7113	Gene	Gene	Fusion|appos|START_ENTITY Fusion|nmod|members members|compound|END_ENTITY	Fusion between TMPRSS2 and ETS family members -LRB- ERG , ETV1 , ETV4 -RRB- in prostate_cancers from northern China .
24149465	0	ERG	57,60	TMPRSS2	49,56	ERG	TMPRSS2	2078	7113	Gene	Gene	Development|dep|START_ENTITY Development|nmod|vaccine vaccine|acl|targeting targeting|dobj|END_ENTITY	Development of a peptide-based vaccine targeting TMPRSS2 : ERG fusion-positive prostate_cancer .
24297949	0	ERG	8,11	TMPRSS2	0,7	ERG	TMPRSS2	2078	7113	Gene	Gene	fusion|compound|START_ENTITY predicts|nsubj|fusion END_ENTITY|parataxis|predicts	TMPRSS2 : ERG gene fusion predicts subsequent detection of prostate_cancer in patients with high-grade prostatic_intraepithelial_neoplasia .
25007891	0	ERG	20,23	TMPRSS2	12,19	ERG	TMPRSS2	2078	7113	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of TMPRSS2 : ERG in molecular stratification of PCa and its association with tumor aggressiveness : a study in Brazilian patients .
25263440	0	ERG	8,11	TMPRSS2	0,7	ERG	TMPRSS2	13876(Tax:10090)	50528(Tax:10090)	Gene	Gene	blocks|nsubj|START_ENTITY END_ENTITY|parataxis|blocks	TMPRSS2 : ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate_cancer proliferation .
25852077	0	ERG	60,63	TMPRSS2	52,59	ERG	TMPRSS2	2078	7113	Gene	Gene	Status|compound|START_ENTITY END_ENTITY|dep|Status	Obesity and Prostate_Cancer Risk According to Tumor TMPRSS2 : ERG Gene Fusion Status .
26935606	0	ERG	35,38	TMPRSS2	27,34	ERG	TMPRSS2	2078	7113	Gene	Gene	gene|compound|START_ENTITY analysis|dep|gene analysis|nmod|END_ENTITY	Functional analysis of the TMPRSS2 : ERG fusion gene in cisplatin - induced cell death .
26941365	0	ERG	58,61	TMPRSS2	50,57	ERG	TMPRSS2	2078	7113	Gene	Gene	Association|dep|START_ENTITY Association|nmod|variants variants|nmod|END_ENTITY	Association of prostate_cancer risk variants with TMPRSS2 : ERG status : evidence for distinct molecular subtypes .
23555854	0	ERG	0,3	Tudor_domain-containing_protein_1	37,70	ERG	Tudor domain-containing protein 1	2078	56165	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	ERG induces epigenetic activation of Tudor_domain-containing_protein_1 -LRB- TDRD1 -RRB- in ERG rearrangement-positive prostate_cancer .
23797726	0	ERG	128,131	a-methylacyl-CoA_racemase	98,123	ERG	a-methylacyl-CoA racemase	2078	23600	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Foamy gland carcinoma_of_the_prostate in needle biopsy : incidence , Gleason grade , and comparative a-methylacyl-CoA_racemase vs. ERG expression .
21170267	0	ERG	0,3	androgen_receptor	20,37	ERG	androgen receptor	2078	367	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	ERG cooperates with androgen_receptor in regulating trefoil_factor_3 in prostate_cancer disease progression .
25899828	0	ERG	7,10	androgen_receptor	115,132	ERG	androgen receptor	2078	367	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|compound|END_ENTITY	Weaker ERG expression in patients with ERG-positive_prostate_cancer is associated with advanced_disease and weaker androgen_receptor expression : An Indian outlook .
16127690	0	ERG	49,52	ether-a-go-go-related	26,47	ERG	ether-a-go-go-related	13876(Tax:10090)	13876(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Expression pattern of the ether-a-go-go-related -LRB- ERG -RRB- family proteins in the adult mouse central nervous system : evidence for coassembly of different subunits .
11680687	0	ERG	12,15	ets_related_gene	17,33	ERG	ets related gene	374146(Tax:9031)	374146(Tax:9031)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of ERG -LRB- ets_related_gene -RRB- in cartilage development .
23480797	0	ERG	19,22	miR-145	47,54	ERG	miR-145	2078	406937	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The proto-oncogene ERG is a target of microRNA miR-145 in prostate_cancer .
19811652	0	ERG-associated_protein_with_SET_domain	0,38	Oct4	46,50	ERG-associated protein with SET domain	Oct4	9869	5460	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	ERG-associated_protein_with_SET_domain -LRB- ESET -RRB- - Oct4 interaction regulates pluripotency and represses the trophectoderm lineage .
15750627	0	ERG1	47,51	ETS-related_gene-1	27,45	ERG1	ETS-related gene-1	3757	3757	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Frequent overexpression of ETS-related_gene-1 -LRB- ERG1 -RRB- in prostate_cancer transcriptome .
21075079	0	ERG1	66,70	MGA2	11,15	ERG1	MGA2	853086(Tax:4932)	854851(Tax:4932)	Gene	Gene	transcription|nmod|START_ENTITY role|nmod|transcription role|nmod|END_ENTITY	A role for MGA2 , but not SPT23 , in activation of transcription of ERG1 in Saccharomyces_cerevisiae .
8038180	0	ERG6	19,23	LIS1	13,17	ERG6	LIS1	855003(Tax:4932)	855003(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in LIS1 -LRB- ERG6 -RRB- gene confer increased sodium and lithium uptake in Saccharomyces_cerevisiae .
11255007	0	ERGIC-53	30,38	ERGL	0,4	ERGIC-53	ERGL	3998	79748	Gene	Gene	related|nmod|START_ENTITY gene|acl|related END_ENTITY|appos|gene	ERGL , a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues .
17010120	0	ERGIC-53	25,33	MCFD2	34,39	ERGIC-53	MCFD2	3998	90411	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Cargo selectivity of the ERGIC-53 / MCFD2 transport receptor complex .
18283111	0	ERGIC-53	18,26	alpha1-antitrypsin	69,87	ERGIC-53	alpha1-antitrypsin	3998	5265	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin .
11255007	0	ERGL	0,4	ERGIC-53	30,38	ERGL	ERGIC-53	79748	3998	Gene	Gene	START_ENTITY|appos|gene gene|acl|related related|nmod|END_ENTITY	ERGL , a novel gene related to ERGIC-53 that is highly expressed in normal and neoplastic prostate and several other tissues .
20087163	0	ERK	53,56	ADAM-17	0,7	ERK	ADAM-17	5594	6868	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	ADAM-17 is activated by the mitogenic protein kinase ERK in a model of kidney_fibrosis .
16984917	0	ERK	112,115	AKT	106,109	ERK	AKT	5594	207	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	A splice variant of CD99 increases motility and MMP-9 expression of human breast_cancer cells through the AKT - , ERK - , and JNK-dependent AP-1 activation signaling pathways .
21263216	0	ERK	14,17	AKT	32,35	ERK	AKT	5594	207	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks .
23567182	0	ERK	37,40	AKT	20,23	ERK	AKT	26413(Tax:10090)	11651(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY Compensation|acl|signaling Compensation|nmod|END_ENTITY	Compensation of the AKT signaling by ERK signaling in transgenic_mice hearts overexpressing TRIM72 .
24117170	0	ERK	86,89	AKT	91,94	ERK	AKT	2048	207	Gene	Gene	STAT3|compound|START_ENTITY STAT3|appos|END_ENTITY	Differential expression and activation of epidermal growth factor receptor 1 -LRB- EGFR1 -RRB- , ERK , AKT , STAT3 , and TWIST1 in nonsmall_cell_lung_cancer -LRB- NSCLC -RRB- .
12485852	0	ERK	14,17	Akt	52,55	ERK	Akt	26413(Tax:10090)	11651(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|acl|controlled controlled|nmod|Rac1 Rac1|nmod|END_ENTITY	Activation of ERK , controlled by Rac1 and Cdc42 via Akt , is required for anoikis .
15056728	0	ERK	69,72	Akt	96,99	ERK	Akt	24338(Tax:10116)	24185(Tax:10116)	Gene	Gene	extracellular_signal-regulated_protein_kinase|appos|START_ENTITY extracellular_signal-regulated_protein_kinase|appos|END_ENTITY	In vivo regulation of extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- and protein kinase B -LRB- Akt -RRB- phosphorylation by acute and chronic morphine .
15115658	0	ERK	96,99	Akt	90,93	ERK	Akt	2048	207	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase / Akt - , ERK - , and Src family kinase-dependent pathway .
15857394	0	ERK	84,87	Akt	39,42	ERK	Akt	5594	207	Gene	Gene	couple|appos|START_ENTITY couple|nmod|activation activation|nmod|END_ENTITY	5-HT receptors couple to activation of Akt , but not extracellular-regulated_kinase -LRB- ERK -RRB- , in cultured hippocampal neurons .
16885155	0	ERK	0,3	Akt	96,99	ERK	Akt	5594	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	ERK promotes hydrogen_peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells .
18256541	0	ERK	16,19	Akt	0,3	ERK	Akt	5594	207	Gene	Gene	START_ENTITY|nsubj|inactivates inactivates|compound|END_ENTITY	Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells .
20816750	0	ERK	137,140	Akt	132,135	ERK	Akt	5594	207	Gene	Gene	v|appos|START_ENTITY v|dep|END_ENTITY	Fibronectin and vitronectin induce AP-1-mediated matrix metalloproteinase-9 expression through integrin a -LRB- 5 -RRB- b -LRB- 1 -RRB- / a -LRB- v -RRB- b -LRB- 3 -RRB- - dependent Akt , ERK and JNK signaling pathways in human umbilical vein endothelial cells .
22147269	0	ERK	54,57	Akt	68,71	ERK	Akt	24338(Tax:10116)	24185(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|parataxis|confer confer|nsubj|END_ENTITY	Upregulation of heme_oxygenase-1 by acteoside through ERK and PI3_K / Akt pathway confer neuroprotection against beta-amyloid-induced neurotoxicity .
24088818	0	ERK	99,102	Akt	94,97	ERK	Akt	5594	207	Gene	Gene	Src|appos|START_ENTITY Src|compound|END_ENTITY	ErbB2 upregulates the Na + , HCO3 -LRB- - -RRB- - cotransporter NBCn1/SLC4A7 in human breast_cancer cells via Akt , ERK , Src , and Kruppel-like factor 4 .
26821209	0	ERK	145,148	Akt	120,123	ERK	Akt	5594	207	Gene	Gene	pathways|compound|START_ENTITY induced|dobj|pathways induced|dep|/ /|compound|END_ENTITY	Long chain n-3 polyunsaturated_fatty_acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKC / - induced ERK pathways .
20726858	0	ERK	41,44	Amphiregulin	0,12	ERK	Amphiregulin	5594	374	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Amphiregulin regulates the activation of ERK and Akt through epidermal_growth_factor_receptor and HER3 signals involved in the progression of pancreatic_cancer .
18490924	0	ERK	22,25	B-Raf	0,5	ERK	B-Raf	26413(Tax:10090)	109880(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic_beta-cell_carcinogenesis .
21812548	0	ERK	100,103	B-type_natriuretic_peptide	69,95	ERK	B-type natriuretic peptide	24338(Tax:10116)	25105(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	M-CAT element mediates mechanical stretch-activated transcription of B-type_natriuretic_peptide via ERK activation .
15121878	0	ERK	144,147	BAD	77,80	ERK	BAD	5594	572	Gene	Gene	signaling|nmod|START_ENTITY requiring|advcl|signaling pathways|acl|requiring inactivation|dep|pathways inactivation|nmod|END_ENTITY	Estradiol abrogates apoptosis in breast_cancer cells through inactivation of BAD : Ras-dependent nongenomic pathways requiring signaling through ERK and Akt .
15184373	0	ERK	59,62	BRAF	107,111	ERK	BRAF	5594	673	Gene	Gene	pathway|compound|START_ENTITY mediated|nmod|pathway mediated|nmod|cells cells|dep|role role|nmod|mutation mutation|compound|END_ENTITY	Overexpression of collagenase 1 -LRB- MMP-1 -RRB- is mediated by the ERK pathway in invasive melanoma cells : role of BRAF mutation and fibroblast growth factor signaling .
20149136	0	ERK	65,68	BRAF	21,25	ERK	BRAF	5594	673	Gene	Gene	pathway|compound|START_ENTITY activates|dobj|pathway activates|nsubj|PLX4032 PLX4032|appos|inhibitor inhibitor|compound|END_ENTITY	PLX4032 , a selective BRAF -LRB- V600E -RRB- kinase inhibitor , activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells .
23544999	0	ERK	0,3	BRAF	74,78	ERK	BRAF	5594	673	Gene	Gene	phosphorylation|compound|START_ENTITY increased|nsubjpass|phosphorylation increased|nmod|papillary_thyroid_carcinomas papillary_thyroid_carcinomas|nmod|mutation mutation|compound|END_ENTITY	ERK phosphorylation is not increased in papillary_thyroid_carcinomas with BRAF -LRB- V600E -RRB- mutation compared to that of corresponding normal thyroid tissues .
23614898	0	ERK	21,24	BRAF	85,89	ERK	BRAF	5594	673	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nmod|activity activity|nmod|models models|nmod|resistance resistance|nmod|END_ENTITY	Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors .
23749901	0	ERK	86,89	BRAF	93,97	ERK	BRAF	5594	673	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon_cancer cells .
25142146	0	ERK	26,29	BRAF	58,62	ERK	BRAF	5594	673	Gene	Gene	SCH722984|compound|START_ENTITY activity|nmod|SCH722984 activity|nmod|mutant mutant|compound|END_ENTITY	Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant , NRAS mutant and wild-type melanoma .
25329694	0	ERK	26,29	BRAF	0,4	ERK	BRAF	2048	673	Gene	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	BRAF inhibitor-associated ERK activation drives development of chronic_lymphocytic_leukemia .
26134498	0	ERK	38,41	BRAF	70,74	ERK	BRAF	5594	673	Gene	Gene	SCH722984|compound|START_ENTITY SCH722984|nmod|mutant mutant|compound|END_ENTITY	Erratum to : Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant , NRAS mutant and wild-type melanoma .
14563325	0	ERK	35,38	Bam32	0,5	ERK	Bam32	26413(Tax:10090)	26377(Tax:10090)	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival .
15225643	0	ERK	81,84	Bcl-2	58,63	ERK	Bcl-2	5594	596	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|status status|nmod|END_ENTITY	The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein_phosphatase_2A on the mitochondria .
16914120	0	ERK	75,78	Bcl-2	0,5	ERK	Bcl-2	24338(Tax:10116)	24224(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY disrupts|nmod|activation disrupts|nsubj|overexpression overexpression|amod|END_ENTITY	Bcl-2 overexpression disrupts the morphology of PC12 cells through reduced ERK activation .
17052670	0	ERK	125,128	Bcl-2	50,55	ERK	Bcl-2	5594	596	Gene	Gene	downregulation|nmod|START_ENTITY END_ENTITY|nmod|downregulation	Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt .
18454859	0	ERK	147,150	Bcl-2	96,101	ERK	Bcl-2	5594	596	Gene	Gene	extracellular_signal-related_kinase|appos|START_ENTITY END_ENTITY|nmod|extracellular_signal-related_kinase	Expression of HER-2 in MCF-7 breast_cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular_signal-related_kinase -LRB- ERK -RRB- and phosphoinositide-3 kinase -LRB- PI3K -RRB- signalling pathways .
18677583	0	ERK	28,31	Bcl-2	63,68	ERK	Bcl-2	5594	596	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|induction induction|nmod|END_ENTITY	Evidence for involvement of ERK , PI3K , and RSK in induction of Bcl-2 by valproate .
22504301	0	ERK	114,117	Bcl-2	43,48	ERK	Bcl-2	5594	596	Gene	Gene	activation|nmod|START_ENTITY activating|nmod|activation enhances|advcl|activating enhances|dobj|expression expression|compound|END_ENTITY	Overexpression of phospholipase_D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells .
23735541	0	ERK	128,131	Bcl-2	36,41	ERK	Bcl-2	5594	596	Gene	Gene	inhibition|compound|START_ENTITY modulated|nmod|inhibition modulated|nsubjpass|Apoptosis Apoptosis|acl|induced induced|nmod|activation activation|amod|paclitaxel paclitaxel|nmod|END_ENTITY	Apoptosis induced by paclitaxel via Bcl-2 , Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition .
25996258	0	ERK	39,42	Bcl-2	16,21	ERK	Bcl-2	5594	596	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis .
16301744	0	ERK	88,91	Bim	76,79	ERK	Bim	26413(Tax:10090)	12125(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway .
17105963	0	ERK	64,67	Bim	14,17	ERK	Bim	26413(Tax:10090)	12125(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein .
26151099	0	ERK	176,179	Bmal1	137,142	ERK	Bmal1	24338(Tax:10116)	29657(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The induction of Per1 expression by the combined treatment with glutamate , 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes .
11028659	0	ERK	81,84	Bradykinin	0,10	ERK	Bradykinin	5594	3827	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK - and p38_MAPK-dependent mechanisms .
24043631	0	ERK	29,32	C/EBPb	35,41	ERK	C/EBPb	5594	1051	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	MUC1-C oncoprotein activates ERK > C/EBPb signaling and induction of aldehyde_dehydrogenase_1A1 in breast_cancer cells .
20595030	0	ERK	71,74	CART	47,51	ERK	CART	24338(Tax:10116)	29131(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- peptide activates ERK pathways via NMDA receptors in rat spinal cord dorsal horn in an age-dependent manner .
20107538	0	ERK	58,61	CD147	19,24	ERK	CD147	5594	682	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages : Implication for Atherosclerosis .
20847954	0	ERK	80,83	CD147	14,19	ERK	CD147	5594	682	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of CD147 with cyclophilin_a induces the expression of IFITM1 through ERK and PI3K in THP-1 cells .
25996258	0	ERK	39,42	CD147	25,30	ERK	CD147	5594	682	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis .
18008004	0	ERK	20,23	CD200	0,5	ERK	CD200	5594	4345	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	CD200 is induced by ERK and is a potential therapeutic target in melanoma .
16356505	0	ERK	56,59	CD40	32,36	ERK	CD40	5594	958	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	Chylomicron remnants upregulate CD40 expression via the ERK pathway and a redox-sensitive mechanism in THP-1 cells .
11880483	0	ERK	110,113	CREB	136,140	ERK	CREB	5594	1385	Gene	Gene	activation|compound|START_ENTITY activation|acl|coupled coupled|nmod|END_ENTITY	Brain-derived_neurotrophic_factor induces long-term potentiation in intact adult hippocampus : requirement for ERK activation coupled to CREB and upregulation of Arc synthesis .
12540838	0	ERK	11,14	CREB	91,95	ERK	CREB	5594	1385	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|activity activity|appos|END_ENTITY	Persistent ERK phosphorylation negatively regulates cAMP_response_element-binding_protein -LRB- CREB -RRB- activity via recruitment of CREB-binding_protein to pp90RSK .
16678346	0	ERK	9,12	CREB	23,27	ERK	CREB	5594	1385	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Enhanced ERK dependent CREB activation reduces apoptosis in staurosporine-treated human neuroblastoma SK-N-BE -LRB- 2 -RRB- C cells .
26424114	0	ERK	112,115	CREB	134,138	ERK	CREB	24338(Tax:10116)	81646(Tax:10116)	Gene	Gene	proceed|nmod|START_ENTITY proceed|xcomp|induce induce|dobj|END_ENTITY	FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation .
23308188	0	ERK	75,78	CXCR4	104,109	ERK	CXCR4	26413(Tax:10090)	12767(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	RasGRP1 , but not RasGRP3 , is required for efficient thymic b-selection and ERK activation downstream of CXCR4 .
12468029	0	ERK	34,37	Ca2	123,126	ERK	Ca2	5594	760	Gene	Gene	START_ENTITY|parataxis|involves involves|ccomp|+ +|nsubj|END_ENTITY	Activation of the neuroprotective ERK signaling pathway by fructose-1 ,6 - bisphosphate during hypoxia involves intracellular Ca2 + and phospholipase C .
18478546	0	ERK	101,104	Ca2	82,85	ERK	Ca2	24338(Tax:10116)	54231(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2 + / CaM-dependent ERK activation in cerebral_ischemia .
10234573	0	ERK	0,3	Cdk2	39,43	ERK	Cdk2	5594	1017	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells .
26151562	0	ERK	58,61	Cortactin	0,9	ERK	Cortactin	5594	2017	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Cortactin promotes colon_cancer progression by regulating ERK pathway .
26151562	0	ERK	58,61	Cortactin	0,9	ERK	Cortactin	5594	2017	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Cortactin promotes colon_cancer progression by regulating ERK pathway .
21401930	0	ERK	15,18	Corto	86,91	ERK	Corto	3354888(Tax:7227)	40616(Tax:7227)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development .
12149127	0	ERK	75,78	D1_and_D2	30,39	ERK	D1 and D2	5594	25802	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Involvement of phospholipases D1_and_D2 in sphingosine_1-phosphate-induced ERK -LRB- extracellular-signal-regulated_kinase -RRB- activation and interleukin-8 secretion in human bronchial epithelial cells .
26048984	0	ERK	52,55	DJ-1	67,71	ERK	DJ-1	5594	11315	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Epidermal_growth_factor-dependent activation of the ERK pathway by DJ-1 through its direct binding to c-Raf .
16081065	0	ERK	110,113	DUSP1	29,34	ERK	HIF-1	5594	3091	Gene	Gene	MAPK|compound|START_ENTITY inactivating|dobj|MAPK protects|advcl|inactivating protects|nsubj|END_ENTITY	Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible_factor_1 through inactivating ERK MAPK .
22897852	0	ERK	137,140	DUSP1	113,118	ERK	DUSP1	26413(Tax:10090)	19252(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Therapeutic effect of y-secretase inhibition in KrasG12V-driven non-small_cell_lung_carcinoma by derepression of DUSP1 and inhibition of ERK .
20097731	0	ERK	99,102	DUSP6	32,37	ERK	DUSP6	5594	1848	Gene	Gene	mediator|nmod|START_ENTITY mediator|nsubj|Dual_specificity_phosphatase_6 Dual_specificity_phosphatase_6|appos|END_ENTITY	Dual_specificity_phosphatase_6 -LRB- DUSP6 -RRB- is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung_cancer cells .
21680106	0	ERK	52,55	DUSP6	27,32	ERK	DUSP6	5594	1848	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Differential expression of DUSP6 with expression of ERK and Ki-67 in non-small_cell_lung_carcinoma .
22155192	0	ERK	73,76	DUSP6	27,32	ERK	DUSP6	5594	1848	Gene	Gene	activity|compound|START_ENTITY association|nmod|activity association|nmod|END_ENTITY	The genetic association of DUSP6 with bipolar_disorder and its effect on ERK activity .
25489104	0	ERK	49,52	Dual-specificity_phosphatase_5	0,30	ERK	Dual-specificity phosphatase 5	26413(Tax:10090)	240672(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Dual-specificity_phosphatase_5 regulates nuclear ERK activity and suppresses skin_cancer by inhibiting mutant Harvey-Ras -LRB- HRasQ61L -RRB- - driven SerpinB2 expression .
17164422	0	ERK	64,67	Dusp6	0,5	ERK	Dusp6	26413(Tax:10090)	67603(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Dusp6 -LRB- Mkp3 -RRB- is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development .
22923366	0	ERK	50,53	Dyrk1A	0,6	ERK	Dyrk1A	26413(Tax:10090)	13548(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Dyrk1A , a serine/threonine kinase , is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice .
20807437	0	ERK	51,54	EGF	0,3	ERK	EGF	26413(Tax:10090)	13645(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	EGF regulates survivin stability through the Raf-1 / ERK pathway in insulin-secreting pancreatic b-cells .
21220563	0	ERK	93,96	EGF	0,3	ERK	EGF	26413(Tax:10090)	100008808(Tax:9986)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation .
19414352	0	ERK	55,58	EGFR	0,4	ERK	EGFR	2048	1956	Gene	Gene	pathway|compound|START_ENTITY EGR1|nmod|pathway EGR1|nsubj|up-regulates up-regulates|amod|END_ENTITY	EGFR mutation up-regulates EGR1 expression through the ERK pathway .
21989899	0	ERK	41,44	EGFR	14,18	ERK	EGFR	5594	1956	Gene	Gene	phosphorylated|dobj|START_ENTITY phosphorylated|nsubj|Expression Expression|nmod|HER2 HER2|compound|END_ENTITY	Expression of EGFR , HER2 , phosphorylated ERK and phosphorylated MEK in colonic_neoplasms of familial_adenomatous_polyposis patients .
22961667	0	ERK	16,19	EGFR	51,55	ERK	EGFR	5594	1956	Gene	Gene	signaling|compound|START_ENTITY Reactivation|nmod|signaling causes|nsubj|Reactivation causes|nmod|inhibitors inhibitors|amod|END_ENTITY	Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors .
23671927	0	ERK	10,13	EGFR	40,44	ERK	EGFR	5594	1956	Gene	Gene	-LSB-|compound|START_ENTITY -LSB-|acl|corrected corrected|nmod|therapies therapies|amod|END_ENTITY	Sustained ERK -LSB- corrected -RSB- inhibition by EGFR targeting therapies is a predictive factor for synergistic_cytotoxicity with PDT as neoadjuvant therapy .
24966948	0	ERK	25,28	EGFR	74,78	ERK	EGFR	5594	1956	Gene	Gene	expression|compound|START_ENTITY Significance|nmod|expression Significance|nmod|END_ENTITY	Significance of elevated ERK expression and its positive correlation with EGFR in Kazakh patients with esophageal_squamous_cell_carcinoma .
25246059	0	ERK	92,95	EGFR	121,125	ERK	EGFR	5594	1956	Gene	Gene	Mediated|compound|START_ENTITY Cells|nmod|Mediated Cells|nmod|Pathway Pathway|compound|END_ENTITY	Inhibitory Effects of Scutellarein on Proliferation of Human Lung Cancer A549 Cells through ERK and NFkB Mediated by the EGFR Pathway .
25953087	0	ERK	117,120	EGFR	72,76	ERK	EGFR	5594	1956	Gene	Gene	Extracellular_Signal-regulated_Kinase|appos|START_ENTITY Induce|dep|Extracellular_Signal-regulated_Kinase Induce|dep|Epidermal_Growth_Factor_Receptor Epidermal_Growth_Factor_Receptor|appos|END_ENTITY	Activating PIK3CA Mutations Induce an Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- / Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- Paracrine Signaling Axis in Basal-like Breast_Cancer .
19414352	0	ERK	55,58	EGR1	27,31	ERK	EGR1	2048	1958	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	EGFR mutation up-regulates EGR1 expression through the ERK pathway .
15123663	0	ERK	84,87	EP4	64,67	ERK	EP4	26413(Tax:10090)	19219(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Colon_carcinoma cell growth is associated with prostaglandin_E2 / EP4 receptor-evoked ERK activation .
12055094	0	ERK	16,19	ET-1	0,4	ERK	ET-1	26413(Tax:10090)	13614(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells .
14644778	0	ERK	69,72	ET-1	87,91	ERK	ET-1	24338(Tax:10116)	24323(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Contribution of PKC-dependent and - independent processes in temporal ERK regulation by ET-1 , PDGF , and EGF in rat myometrial cells .
11331872	0	ERK	0,3	Egr1	75,79	ERK	Egr1	24338(Tax:10116)	24330(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	ERK induces p35 , a neuron-specific activator of Cdk5 , through induction of Egr1 .
25953087	0	ERK	117,120	Epidermal_Growth_Factor_Receptor	38,70	ERK	Epidermal Growth Factor Receptor	5594	1956	Gene	Gene	Extracellular_Signal-regulated_Kinase|appos|START_ENTITY Induce|dep|Extracellular_Signal-regulated_Kinase Induce|dep|END_ENTITY	Activating PIK3CA Mutations Induce an Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- / Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- Paracrine Signaling Axis in Basal-like Breast_Cancer .
24905473	0	ERK	123,126	Epidermal_growth_factor	0,23	ERK	Epidermal growth factor	2048	1950	Gene	Gene	activation|compound|START_ENTITY inhibits|nmod|activation inhibits|nsubj|END_ENTITY	Epidermal_growth_factor inhibits transforming_growth_factor-b-induced fibrogenic differentiation marker expression through ERK activation .
25975912	0	ERK	106,109	Epidermal_growth_factor-like_domain_7	1,38	ERK	Epidermal growth factor-like domain 7	5594	51162	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	-LSB- Epidermal_growth_factor-like_domain_7 promotes endothelial cell migration and angiogenesis by activating ERK signaling pathway -RSB- .
14581411	0	ERK	63,66	Epiregulin	0,10	ERK	Epiregulin	5594	2069	Gene	Gene	cells|amod|START_ENTITY released|nmod|cells released|nsubj|END_ENTITY	Epiregulin as a major autocrine/paracrine factor released from ERK - and p38MAPK-activated vascular smooth muscle cells .
18620900	0	ERK	120,123	Epiregulin	0,10	ERK	Epiregulin	5594	2069	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Epiregulin promotes migration and invasion of salivary adenoid_cystic_carcinoma cell line SACC-83 through activation of ERK and Akt .
22235371	0	ERK	39,42	Extracellular_Signal-Regulated_Kinase	0,37	ERK	Extracellular Signal-Regulated Kinase	5594	5594	Gene	Gene	Activation|appos|START_ENTITY Activation|compound|END_ENTITY	Extracellular_Signal-Regulated_Kinase -LRB- ERK -RRB- Activation and Mitogen-Activated_Protein_Kinase_Phosphatase_1 Induction by Pulsatile Gonadotropin-Releasing_Hormone in Pituitary Gonadotrophs .
26296887	0	ERK	96,99	Extracellular_Signal-regulated_Kinase	57,94	ERK	Extracellular Signal-regulated Kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	Activation|appos|START_ENTITY Activation|compound|END_ENTITY	Lipin1 Regulates Skeletal Muscle Differentiation through Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- Activation and Cyclin D Complex-regulated Cell Cycle Withdrawal .
11776327	0	ERK	39,42	Extracellular_signal-regulated_kinase	0,37	ERK	Extracellular signal-regulated kinase	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation is required for GP_Ibalpha-dependent endothelial cell migration .
17764731	0	ERK	39,42	Extracellular_signal-regulated_kinase	0,37	ERK	Extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- inhibition does not prevent the development or expression of tolerance to and dependence on morphine in the mouse .
24047601	0	ERK	39,42	Extracellular_signal-regulated_kinase	0,37	ERK	Extracellular signal-regulated kinase	5594	5594	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity during sleep consolidates cortical plasticity in vivo .
24682903	0	ERK	39,42	Extracellular_signal-regulated_kinase	0,37	ERK	Extracellular signal-regulated kinase	5594	5594	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- expression and activation in mobile tongue_squamous_cell_carcinoma : associations with clinicopathological parameters and patients survival .
24708812	0	ERK	39,42	Extracellular_signal-regulated_kinase	0,37	ERK	Extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation is required for itch sensation in the spinal cord .
26115165	0	ERK	39,42	Extracellular_signal-regulated_kinase	0,37	ERK	Extracellular signal-regulated kinase	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation is required for porcine_epidemic_diarrhea_virus replication .
20811717	0	ERK	78,81	FAK	116,119	ERK	FAK	5594	5747	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	P21-activated protein kinase 1 induces colorectal_cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910 .
22652804	0	ERK	69,72	FGF-2	63,68	ERK	FGF-2	26413(Tax:10090)	14173(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	TGF-beta_1 induced fibroblast proliferation is mediated by the FGF-2 / ERK pathway .
18204439	0	ERK	0,3	FOXO3a	41,47	ERK	FOXO3a	26413(Tax:10090)	56484(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation .
21604264	0	ERK	37,40	FOXO3a	64,70	ERK	FOXO3a	5594	2309	Gene	Gene	activities|compound|START_ENTITY decreased|dobj|activities decreased|nmod|translocation translocation|amod|END_ENTITY	A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation .
27026230	0	ERK	51,54	GAB2	0,4	ERK	GAB2	5594	9846	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	GAB2 promotes cell proliferation by activating the ERK signaling pathway in hepatocellular_carcinoma .
21635674	0	ERK	18,21	GLP-1	0,5	ERK	GLP-1	26413(Tax:10090)	14526(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	GLP-1 signals via ERK in peripheral nerve and prevents nerve_dysfunction in diabetic mice .
20398804	0	ERK	0,3	GM-CSF	18,24	ERK	GM-CSF	5594	1437	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	ERK activation by GM-CSF reduces effectiveness of p38 inhibitor on inhibiting TNFalpha release .
24396730	0	ERK	37,40	GPCR	22,26	ERK	GPCR	5594	442206	Gene	Gene	Pathways|compound|START_ENTITY Pathways|compound|END_ENTITY	Minireview : Targeting GPCR Activated ERK Pathways for Drug Discovery .
23921150	0	ERK	57,60	Ghrelin	0,7	ERK	Ghrelin	26413(Tax:10090)	58991(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway .
25572615	0	ERK	96,99	Glypican-3	0,10	ERK	Glypican-3	5594	2719	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Glypican-3 promotes epithelial-mesenchymal transition of hepatocellular_carcinoma cells through ERK signaling pathway .
22235371	0	ERK	39,42	Gonadotropin-Releasing_Hormone	129,159	ERK	Gonadotropin-Releasing Hormone	5594	2796	Gene	Gene	Activation|appos|START_ENTITY Induction|nsubj|Activation Induction|nmod|END_ENTITY	Extracellular_Signal-Regulated_Kinase -LRB- ERK -RRB- Activation and Mitogen-Activated_Protein_Kinase_Phosphatase_1 Induction by Pulsatile Gonadotropin-Releasing_Hormone in Pituitary Gonadotrophs .
26644469	0	ERK	112,115	Gonadotropin-Releasing_Hormone	24,54	ERK	Gonadotropin-Releasing Hormone	5594	2796	Gene	Gene	Kinase|appos|START_ENTITY Transfer|dep|Kinase Transfer|nmod|Signaling Signaling|compound|END_ENTITY	Information Transfer in Gonadotropin-Releasing_Hormone -LRB- GnRH -RRB- Signaling : Extracellular Signal-Regulated Kinase -LRB- ERK -RRB- - Mediated Feedback Loops Control Hormone Sensing .
19179479	0	ERK	65,68	Gonadotropin-releasing_hormone	0,30	ERK	Gonadotropin-releasing hormone	5594	2796	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Gonadotropin-releasing_hormone and protein kinase C signaling to ERK : spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases .
19179479	0	ERK	99,102	Gonadotropin-releasing_hormone	0,30	ERK	Gonadotropin-releasing hormone	5594	2796	Gene	Gene	regulation|nmod|START_ENTITY signaling|dep|regulation signaling|compound|END_ENTITY	Gonadotropin-releasing_hormone and protein kinase C signaling to ERK : spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases .
10683440	0	ERK	0,3	HIF-1	44,49	ERK	HIF-1	5594	3091	Gene	Gene	activation|compound|START_ENTITY activation|dep|involvement involvement|nmod|activation activation|compound|END_ENTITY	ERK activation upon hypoxia : involvement in HIF-1 activation .
12447987	0	ERK	8,11	HIF-1	61,66	ERK	HIF-1	5594	3091	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|nmod|END_ENTITY	Role of ERK and calcium in the hypoxia-induced activation of HIF-1 .
21059928	0	ERK	111,114	HIF-1	96,101	ERK	HIF-1	5594	3091	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- via the ERK pathway after hyperthermia treatment .
23936001	0	ERK	65,68	HIF-1a	20,26	ERK	HIF-1a	5594	3091	Gene	Gene	inhibition|nmod|START_ENTITY VEGF|nmod|inhibition END_ENTITY|parataxis|VEGF	Melittin suppresses HIF-1a / VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical_carcinoma cells .
24627260	0	ERK	41,44	HIF-1a	16,22	ERK	HIF-1a	24338(Tax:10116)	29560(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Upregulation of HIF-1a via activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial_injury in neuron-like cells .
16533045	0	ERK	0,3	HMG1-boxes_1_and_2	71,89	ERK	HMG1-boxes 1 and 2	5594	10354	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes_1_and_2 of the RNA polymerase I transcription factor UBF .
15993334	0	ERK	45,48	HO-1	14,18	ERK	HO-1	5594	3162	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway increases|nmod|activation increases|dobj|END_ENTITY	HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells .
19686811	0	ERK	79,82	HO-1	55,59	ERK	HO-1	5594	3162	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Quercetin-3-O-beta-d-glucuronopyranoside -LRB- QGC -RRB- - induced HO-1 expression through ERK and PI3K activation in cultured feline esophageal epithelial cells .
23569422	0	ERK	107,110	HO-1	94,98	ERK	HO-1	5594	3162	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Propofol-induced protection of SH-SY5Y cells against hydrogen_peroxide is associated with the HO-1 via the ERK pathway .
25007817	0	ERK	46,49	HO-1	14,18	ERK	HO-1	5594	3162	Gene	Gene	coupled|nmod|START_ENTITY induction|acl|coupled induction|compound|END_ENTITY	Nrf2-mediated HO-1 induction coupled with the ERK signaling pathway contributes to indirect antioxidant capacity of caffeic_acid_phenethyl_ester in HepG2 cells .
19012179	0	ERK	75,78	Hematopoietic_lineage_cell-specific_protein-1	0,45	ERK	Hematopoietic lineage cell-specific protein-1	26413(Tax:10090)	15163(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Hematopoietic_lineage_cell-specific_protein-1 -LRB- HS1 -RRB- regulates PAR-mediated ERK activation and thromboxane generation in platelets .
16456541	0	ERK	36,39	IEX-1_and_ERK	91,104	ERK	IEX-1 and ERK	5594	8870;5594	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1_and_ERK .
12234375	0	ERK	15,18	IFNalpha	93,101	ERK	IFNalpha	5594	3439	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Protein kinase ERK contributes to differential responsiveness of human myeloma cell lines to IFNalpha .
21507199	0	ERK	75,78	IL-10	0,5	ERK	IL-10	5594	3586	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|compound|END_ENTITY	IL-10 production in non-small_cell_lung_carcinoma patients is regulated by ERK , P38 and COX-2 .
11709700	0	ERK	109,112	IL-4	48,52	ERK	IL-4	5594	3565	Gene	Gene	pathways|compound|START_ENTITY involvement|nmod|pathways Induction|dep|involvement Induction|nmod|receptor receptor|amod|alpha2-chain alpha2-chain|nmod|END_ENTITY	Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes : involvement of STAT6 , ERK and p38 MAPK pathways .
15843535	0	ERK	84,87	IL-4	34,38	ERK	IL-4	5594	3565	Gene	Gene	activation|compound|START_ENTITY pathway|nmod|activation creates|dobj|pathway creates|nsubj|END_ENTITY	B cell receptor -LRB- BCR -RRB- cross-talk : IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent .
19065352	0	ERK	61,64	IL-4	137,141	ERK	IL-4	5594	3565	Gene	Gene	extracellular_signal-regulated_kinases|appos|START_ENTITY effect|nmod|extracellular_signal-regulated_kinases effect|acl|stimulated stimulated|nmod|END_ENTITY	Regulatory effect of extracellular_signal-regulated_kinases -LRB- ERK -RRB- on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13 .
11028659	0	ERK	81,84	IL-6	22,26	ERK	IL-6	5594	3569	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK - and p38_MAPK-dependent mechanisms .
11597988	0	ERK	0,3	IL-6	110,114	ERK	IL-6	5594	3569	Gene	Gene	involved|nsubj|START_ENTITY involved|nmod|induction induction|nmod|END_ENTITY	ERK and p38 MAPK , but not NF-kappaB , are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin_II in cardiac fibroblasts .
17761160	0	ERK	31,34	IL-6	51,55	ERK	IL-6	5594	3569	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes .
21081304	0	ERK	26,29	IL-6	21,25	ERK	IL-6	5594	3569	Gene	Gene	Relationship|dep|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between IL-6 / ERK and NF-kB : a study in normal and pathological human prostate gland .
21263382	0	ERK	98,101	IL-6	0,4	ERK	IL-6	26413(Tax:10090)	16193(Tax:10090)	Gene	Gene	-|compound|START_ENTITY stem|nmod|- stem|nsubj|END_ENTITY	IL-6 and TGF-a costimulate mesenchymal stem cell vascular_endothelial_growth_factor production by ERK - , JNK - , and PI3K-mediated mechanisms .
21469095	0	ERK	90,93	IL-6	56,60	ERK	IL-6	26413(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY cells|nmod|activation production|nmod|cells production|compound|END_ENTITY	Histamine H receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation .
20517899	0	ERK	72,75	Insulin	0,7	ERK	Insulin	5594	3630	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells .
25091703	0	ERK	136,139	Interleukin-1b	0,14	ERK	Interleukin-1b	5594	3553	Gene	Gene	activation|nmod|START_ENTITY promotes|parataxis|activation promotes|nsubj|END_ENTITY	Interleukin-1b promotes the LC3-mediated secretory function of osteoclast precursors by stimulating the Ca - dependent activation of ERK .
26858639	0	ERK	121,124	Interleukin-1b	56,70	ERK	Interleukin-1b	5594	3553	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	Thromboxane_A2 Receptor Stimulation Enhances Microglial Interleukin-1b and NO_Biosynthesis Mediated by the Activation of ERK Pathway .
19967052	0	ERK	9,12	Interleukin-8	30,43	ERK	Interleukin-8	5594	3576	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|Expression Expression|compound|END_ENTITY	Roles of ERK and NF-kappaB in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells .
12589789	0	ERK	70,73	Interleukin_15	0,14	ERK	Interleukin 15	5594	3600	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin_15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line , HaCaT .
11104676	0	ERK	74,77	JNK	108,111	ERK	JNK	26413(Tax:10090)	26419(Tax:10090)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Compartment-specific regulation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- mitogen-activated protein kinases -LRB- MAPKs -RRB- by ERK-dependent and non-ERK-dependent inductions of MAPK_phosphatase _ -LRB- MKP -RRB- -3 and MKP-1 in differentiating P19 cells .
11330828	0	ERK	131,134	JNK	165,168	ERK	JNK	5594	5599	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun-N-terminal_kinase -LRB- JNK -RRB- .
12237195	0	ERK	113,116	JNK	147,150	ERK	JNK	24338(Tax:10116)	116554(Tax:10116)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus .
14667452	0	ERK	75,78	JNK	109,112	ERK	JNK	5594	5599	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Nitric_oxide-mediated activation of extracellular signal-regulated kinase -LRB- ERK -RRB- and c-jun_N-terminal_kinase -LRB- JNK -RRB- during hypoxia in cerebral cortical nuclei of newborn piglets .
20432452	0	ERK	140,143	JNK	145,148	ERK	JNK	5594	5599	Gene	Gene	AP-1|compound|START_ENTITY AP-1|appos|END_ENTITY	Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid_arthritis synovial fibroblasts : involvement of ERK , JNK , AP-1 , and NF-kappaB .
21604264	0	ERK	37,40	JNK	15,18	ERK	JNK	5594	5599	Gene	Gene	activities|compound|START_ENTITY decreased|dobj|activities decreased|nsubj|pathway pathway|nmod|END_ENTITY	A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation .
22689214	0	ERK	45,48	JNK	40,43	ERK	JNK	5594	5599	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Effect of HSP70 and 90 in modulation of JNK , ERK expression in preeclamptic placental endothelial cell .
9362525	0	ERK	97,100	JNK	131,134	ERK	JNK	5594	5599	Gene	Gene	extracellular_signal-regulated_kinase|dep|START_ENTITY activation|amod|extracellular_signal-regulated_kinase activation|appos|END_ENTITY	Cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA-4 -RRB- interferes with extracellular_signal-regulated_kinase -LRB- ERK -RRB- and Jun_NH2-terminal_kinase -LRB- JNK -RRB- activation , but does not affect phosphorylation of T cell receptor zeta and ZAP70 .
22342683	0	ERK	47,50	K-Ras	0,5	ERK	K-Ras	5594	3845	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic_ductal_adenocarcinomas .
24215674	0	ERK	71,74	K-Ras	57,62	ERK	K-Ras	5594	3845	Gene	Gene	oleanane_triterpenoid|nmod|START_ENTITY oleanane_triterpenoid|dobj|END_ENTITY	Novel synthetic oleanane_triterpenoid AMR-MeOAc inhibits K-Ras through ERK , Akt and survivin in pancreatic_cancer cells .
11162624	0	ERK	50,53	K-ras	35,40	ERK	K-ras	5594	3845	Gene	Gene	activity|compound|START_ENTITY suppress|dobj|activity suppress|nsubj|cells cells|nmod|END_ENTITY	Pancreatic_tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP_kinase_phosphatase-2 .
26732596	0	ERK	22,25	KRAS	48,52	ERK	KRAS	24338(Tax:10116)	24525(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|nmod|END_ENTITY	MiR-126 Regulates the ERK Pathway via Targeting KRAS to Inhibit the Glioma Cell Proliferation and Invasion .
17613518	0	ERK	40,43	KSR1	76,80	ERK	KSR1	26413(Tax:10090)	16706(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1 .
20865788	0	ERK	48,51	Kinase_suppressor_of_Ras_1	0,26	ERK	Kinase suppressor of Ras 1	26413(Tax:10090)	16706(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Kinase_suppressor_of_Ras_1 is required for full ERK activation in thymocytes but not for thymocyte selection .
15487973	0	ERK	50,53	LK6	30,33	ERK	LK6	3354888(Tax:7227)	44672(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo .
25728771	0	ERK	11,14	MCRIP1	0,6	ERK	MCRIP1	5594	348262	Gene	Gene	Substrate|compound|START_ENTITY END_ENTITY|appos|Substrate	MCRIP1 , an ERK Substrate , Mediates ERK-Induced Gene Silencing during Epithelial-Mesenchymal Transition by Regulating the Co-Repressor CtBP .
21453480	0	ERK	208,211	MEK	164,167	ERK	MEK	5594	5609	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
25774218	0	ERK	220,223	MEK	176,179	ERK	MEK	5594	5609	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Erratum to : Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
26208884	0	ERK	31,34	MEK1	0,4	ERK	MEK1	26413(Tax:10090)	26395(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages .
23261059	0	ERK	159,162	MITF	94,98	ERK	MITF	26413(Tax:10090)	17342(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells .
26263195	0	ERK	83,86	MITF	107,111	ERK	MITF	5594	4286	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	Inhibitory effects of N,N,N-trimethyl _ phytosphingosine-iodide on melanogenesis via ERK activation-mediated MITF degradation .
11878930	0	ERK	72,75	MKP-1	143,148	ERK	MKP-1	5594	1843	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	Hepatitis_C_virus core protein induces cell proliferation and activates ERK , JNK , and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line .
16286470	0	ERK	15,18	MKP-1	35,40	ERK	MKP-1	5594	1843	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|destruction destruction|compound|END_ENTITY	Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling .
18824214	0	ERK	53,56	MKP-1	123,128	ERK	MKP-1	24338(Tax:10116)	114856(Tax:10116)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY Activation|nmod|extracellular_signal-regulated_kinase Activation|appos|END_ENTITY	Activation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and induction of mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP-1 -RRB- by perifused thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation in rat pituitary GH3 cells .
21059338	0	ERK	120,123	MKP-1	135,140	ERK	MKP-1	5594	1843	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor , MKP-1 .
21840882	0	ERK	80,83	MKP-1	102,107	ERK	MKP-1	5594	1843	Gene	Gene	START_ENTITY|nmod|induction induction|compound|END_ENTITY	Tauroursodeoxycholate -LRB- TUDCA -RRB- inhibits neointimal hyperplasia by suppression of ERK via PKCa-mediated MKP-1 induction .
22573375	0	ERK	77,80	MKP-1	93,98	ERK	MKP-1	5594	1843	Gene	Gene	suppression|nmod|START_ENTITY upregulates|nmod|suppression upregulates|advcl|inducing inducing|dobj|END_ENTITY	Hypotonic stress upregulates b - and y-ENaC expression through suppression of ERK by inducing MKP-1 .
21084841	0	ERK	91,94	MKP-2	81,86	ERK	MKP-2	5594	1846	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Post-translational regulation of mitogen-activated_protein_kinase_phosphatase-2 -LRB- MKP-2 -RRB- by ERK .
15033693	0	ERK	45,48	MKP-3	25,30	ERK	MKP-3	3354888(Tax:7227)	40081(Tax:7227)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Drosophila MKP-3 by Drosophila ERK .
14690430	0	ERK	36,39	MKP3	43,47	ERK	MKP3	5594	1848	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Intramolecular dephosphorylation of ERK by MKP3 .
18036345	0	ERK	83,86	MMP-3	62,67	ERK	MMP-3	26413(Tax:10090)	17392(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts .
11069776	0	ERK	10,13	MMP-9	66,71	ERK	MMP-9	5594	4318	Gene	Gene	phosphorylation|compound|START_ENTITY sufficient|nsubj|phosphorylation sufficient|nmod|regulation regulation|compound|END_ENTITY	Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells : involvement of Ras-dependent and - independent pathways .
18834856	0	ERK	35,38	MMP-9	14,19	ERK	MMP-9	5594	4318	Gene	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells .
19082492	0	ERK	93,96	MMP-9	50,55	ERK	MMP-9	5594	4318	Gene	Gene	activation|nmod|START_ENTITY apoptosis|nmod|activation leads|nmod|apoptosis leads|nsubj|downregulation downregulation|nmod|END_ENTITY	RNAi-mediated downregulation of radiation-induced MMP-9 leads to apoptosis via activation of ERK and Akt in IOMM-Lee cells .
19308943	0	ERK	83,86	MMP-9	63,68	ERK	MMP-9	5594	4318	Gene	Gene	pathway|compound|START_ENTITY ameliorates|nmod|pathway ameliorates|dobj|activation activation|compound|END_ENTITY	Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway .
19837106	0	ERK	107,110	MMP-9	26,31	ERK	MMP-9	26413(Tax:10090)	17395(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY macrophages|nmod|activation enhances|nmod|macrophages enhances|dobj|production production|compound|END_ENTITY	4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38_MAPK .
20107538	0	ERK	58,61	MMP-9	33,38	ERK	MMP-9	5594	4318	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages : Implication for Atherosclerosis .
21205837	0	ERK	123,126	MMP-9	98,103	ERK	MMP-9	5594	4318	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|nmod|END_ENTITY	CXCR4 promotes oral_squamous_cell_carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway .
22326992	0	ERK	65,68	MMP-9	22,27	ERK	MMP-9	26413(Tax:10090)	17395(Tax:10090)	Gene	Gene	macrophages|nmod|START_ENTITY signaling|nsubj|macrophages enhances|advcl|signaling enhances|dobj|production production|compound|END_ENTITY	Homocysteine enhances MMP-9 production in murine macrophages via ERK and Akt signaling pathways .
22814256	0	ERK	140,143	MMP-9	75,80	ERK	MMP-9	26413(Tax:10090)	17395(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY regulating|dobj|phosphorylation up-regulate|advcl|regulating up-regulate|dobj|expression expression|compound|END_ENTITY	Atorvastatin and simvastatin , but not pravastatin , up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB .
23271730	0	ERK	105,108	MMP-9	119,124	ERK	MMP-9	5594	4318	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|dep|expression expression|compound|END_ENTITY	Interleukin-20 promotes migration of bladder_cancer cells through extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated MMP-9 protein expression leading to nuclear factor -LRB- NF-kB -RRB- activation by inducing the up-regulation of p21 -LRB- WAF1 -RRB- protein expression .
23681803	0	ERK	154,157	MMP-9	96,101	ERK	MMP-9	5594	4318	Gene	Gene	pathways|compound|START_ENTITY activating|dobj|pathways promote|advcl|activating upregulates|xcomp|promote upregulates|dobj|matrix_metalloproteinase_9 matrix_metalloproteinase_9|appos|END_ENTITY	Ataxia-telangiectasia group D complementing gene -LRB- ATDC -RRB- upregulates matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- to promote lung_cancer cell invasion by activating ERK and JNK pathways .
24448387	0	ERK	174,177	MMP-9	101,106	ERK	MMP-9	5594	4318	Gene	Gene	pathway|compound|START_ENTITY suppression|nmod|pathway cells|nmod|suppression down-regulation|nmod|cells down-regulation|compound|END_ENTITY	9-Hydroxypheophorbide_a-mediated photodynamic therapy induces matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and MMP-9 down-regulation in Hep-2 cells via ROS-mediated suppression of the ERK pathway .
25724188	0	ERK	109,112	MMP-9	42,47	ERK	MMP-9	5594	4318	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|Activation Activation|nmod|END_ENTITY	Activation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by neurotensin promotes cell invasion and migration through ERK pathway in gastric_cancer .
25875631	0	ERK	93,96	MMP-9	40,45	ERK	MMP-9	5594	4318	Gene	Gene	Pathways|compound|START_ENTITY Expression|nmod|Pathways Expression|compound|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
25875631	0	ERK	93,96	MMP-9	40,45	ERK	MMP-9	5594	4318	Gene	Gene	Pathways|compound|START_ENTITY Expression|nmod|Pathways Expression|compound|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
25543044	1	ERK	105,108	MUC2	74,78	ERK	MUC2	5594	4583	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	inhibit PMA-induced MUC2 and MUC5AC expression via ERK inhibition in human airway epithelial cells .
17164422	0	ERK	64,67	Mkp3	7,11	ERK	Mkp3	26413(Tax:10090)	67603(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|Dusp6 Dusp6|appos|END_ENTITY	Dusp6 -LRB- Mkp3 -RRB- is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development .
16891313	0	ERK	57,60	Muc4	15,19	ERK	Muc4	5594	4585	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Membrane mucin Muc4 induces density-dependent changes in ERK activation in mammary epithelial and tumor cells : role in reversal of contact inhibition .
17255949	0	ERK	35,38	Mxi2	0,4	ERK	Mxi2	5594	1432	Gene	Gene	translocation|compound|START_ENTITY promotes|dobj|translocation promotes|nsubj|END_ENTITY	Mxi2 promotes stimulus-independent ERK nuclear translocation .
21217011	0	ERK	84,87	NF-kB1	0,6	ERK	NF-kB1	26413(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY inhibits|nmod|activation inhibits|nsubj|END_ENTITY	NF-kB1 inhibits TLR-induced IFN-b production in macrophages through TPL-2-dependent ERK activation .
14559906	0	ERK	65,68	Nck	58,61	ERK	Nck	5594	4690	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion .
22981806	0	ERK	26,29	Neuropeptide_FF	0,15	ERK	Neuropeptide FF	5594	8620	Gene	Gene	pathways|compound|START_ENTITY activates|dobj|pathways activates|nsubj|END_ENTITY	Neuropeptide_FF activates ERK and NF_kappa_B signal pathways in differentiated SH-SY5Y cells .
21233129	0	ERK	39,42	Nf1	56,59	ERK	Nf1	5594	4763	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Lens induction requires attenuation of ERK signaling by Nf1 .
21270272	0	ERK	45,48	Nrf2	27,31	ERK	Nrf2	26413(Tax:10090)	18024(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo .
15106839	0	ERK	21,24	Nurr1	41,46	ERK	Nurr1	5594	4929	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	Differential role of ERK in cAMP-induced Nurr1 expression in N2A and C6 cells .
22678786	0	ERK	59,62	P-gp	40,44	ERK	P-gp	5594	5243	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Effect of glucosylceramide_synthase on P-gp expression by ERK signal transduction pathway in leukemia multi-drug resistance cell line -RSB- .
21660463	0	ERK	49,52	P53	33,36	ERK	P53	5594	7157	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	ARF triggers cell G1 arrest by a P53 independent ERK pathway .
17950909	0	ERK	25,28	PARP-1	0,6	ERK	PARP-1	5594	142	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	PARP-1 activation in the ERK signaling pathway .
24489888	0	ERK	40,43	PDGFRA	85,91	ERK	PDGFRA	5594	5156	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA .
23836152	0	ERK	89,92	PELP1	113,118	ERK	PELP1	5594	27043	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Vitamin_C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1 .
18413231	0	ERK	0,3	PKC	35,38	ERK	PKC	5594	112476	Gene	Gene	activation|compound|START_ENTITY role|nsubj|activation role|nmod|END_ENTITY	ERK activation is only one role of PKC in TCR-independent cytotoxic T cell granule exocytosis .
21079811	0	ERK	121,124	PKC	115,118	ERK	PKC	5594	112476	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	ER-a36 , a novel variant of ER-a , mediates estrogen-stimulated proliferation of endometrial_carcinoma cells via the PKC / ERK pathway .
12942541	0	ERK	62,65	PKC-zeta	0,8	ERK	PKC-zeta	5594	5590	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	PKC-zeta is required for angiotensin_II-induced activation of ERK and synthesis of C-FOS in MCF-7 cells .
18456255	0	ERK	102,105	PKC_alpha	92,101	ERK	PKC alpha	5594	5578	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interferon-alpha enhances artemisinin-induced differentiation_of_HL-60_leukemia cells via a PKC_alpha / ERK pathway .
15130769	0	ERK	126,129	Peripheral-type_benzodiazepine_receptor	0,39	ERK	Peripheral-type benzodiazepine receptor	5594	706	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Peripheral-type_benzodiazepine_receptor -LRB- PBR -RRB- and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation : role of ERK , c-Jun and ligand-activated PBR-independent pathways .
15385613	0	ERK	40,43	Phosphatidylinositol_3-kinase	0,29	ERK	Phosphatidylinositol 3-kinase	24338(Tax:10116)	298947(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat_hyperalgesia through TRPV1 sensitization .
26265449	0	ERK	98,101	RAF-1	0,5	ERK	RAF-1	5594	5894	Gene	Gene	activation|compound|START_ENTITY harboring|nmod|activation cells|acl|harboring survival|nmod|cells promotes|dobj|survival promotes|nsubj|END_ENTITY	RAF-1 promotes survival of thyroid_cancer cells harboring RET/PTC1 rearrangement independently of ERK activation .
25666350	0	ERK	100,103	RANKL	118,123	ERK	RANKL	26413(Tax:10090)	21943(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Obatoclax Regulates the Proliferation and Fusion of Osteoclast Precursors through the Inhibition of ERK Activation by RANKL .
11948406	0	ERK	92,95	Raf-1	40,45	ERK	Raf-1	5594	5894	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway kinase|nmod|activation kinase|compound|END_ENTITY	PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway .
12954639	0	ERK	96,99	Raf-1	56,61	ERK	Raf-1	5594	5894	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation .
15850570	0	ERK	24,27	Raf-1	32,37	ERK	Raf-1	5594	5894	Gene	Gene	START_ENTITY|nmod|cardiomyocytes cardiomyocytes|amod|END_ENTITY	Peroxynitrite activates ERK via Raf-1 and MEK , independently from EGF_receptor and p21Ras in H9C2 cardiomyocytes .
16172610	0	ERK	0,3	Raf-1	115,120	ERK	Raf-1	5594	5894	Gene	Gene	MAP|compound|START_ENTITY kinase|nsubj|MAP kinase|parataxis|kinases kinases|xcomp|END_ENTITY	ERK MAP kinase signaling in post-mortem brain of suicide subjects : differential regulation of upstream Raf kinases Raf-1 and B-Raf .
20212043	0	ERK	61,64	Raf-1	190,195	ERK	Raf-1	5594	5894	Gene	Gene	activity|dep|START_ENTITY activity|nmod|levels levels|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Mammalian Ste20-like_kinase -LRB- Mst2 -RRB- indirectly supports Raf-1 / ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation .
20212043	0	ERK	61,64	Raf-1	55,60	ERK	Raf-1	5594	5894	Gene	Gene	activity|dep|START_ENTITY supports|dep|activity supports|dobj|END_ENTITY	Mammalian Ste20-like_kinase -LRB- Mst2 -RRB- indirectly supports Raf-1 / ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation .
20807437	0	ERK	51,54	Raf-1	45,50	ERK	Raf-1	26413(Tax:10090)	110157(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	EGF regulates survivin stability through the Raf-1 / ERK pathway in insulin-secreting pancreatic b-cells .
26599016	0	ERK	53,56	Rap1A	0,5	ERK	Rap1A	5594	5906	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated Signaling .
12777392	0	ERK	117,120	RhoA	47,51	ERK	RhoA	24338(Tax:10116)	117273(Tax:10116)	Gene	Gene	translocation|compound|START_ENTITY regulation|nmod|translocation Initiation|dep|regulation Initiation|nmod|END_ENTITY	Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae : cytoskeletal regulation of ERK translocation .
26816343	0	ERK	42,45	RhoA	34,38	ERK	RhoA	5594	387	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and Activation of RhoA by ERK in Response to Epidermal_Growth_Factor Stimulation .
10757524	0	ERK	38,41	S100B	14,19	ERK	S100B	5594	6285	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Extracellular S100B protein modulates ERK in astrocyte cultures .
19723624	0	ERK	22,25	SIP30	0,5	ERK	SIP30	24338(Tax:10116)	257644(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	SIP30 is regulated by ERK in peripheral_nerve_injury-induced neuropathic_pain .
18378670	0	ERK	0,3	STAT1	42,47	ERK	STAT1	5594	6772	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	ERK and the F-box protein betaTRCP target STAT1 for degradation .
21056972	0	ERK	59,62	STAT3	120,125	ERK	STAT3	26413(Tax:10090)	20848(Tax:10090)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Opposing actions of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in regulating microtubule stabilization during cardiac_hypertrophy .
12923167	0	ERK	55,58	Shp2	27,31	ERK	Shp2	5594	5781	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some , but not all , growth factors .
24614941	0	ERK	26,29	Smad1/5	44,51	ERK	Smad1/5	5594	4086;4090	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence .
12717443	0	ERK	46,49	Sprouty4	10,18	ERK	Sprouty4	5594	81848	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 .
23373709	0	ERK	61,64	TGF-b1	54,60	ERK	TGF-b1	24338(Tax:10116)	59086(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY effects|parataxis|signaling effects|nmod|END_ENTITY	The effects of qindan-capsule-containing serum on the TGF-b1 / ERK signaling pathway , matrix metalloproteinase synthesis and cell function in adventitial fibroblasts .
15504369	0	ERK	15,18	TGF-beta	55,63	ERK	TGF-beta	26413(Tax:10090)	21803(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of ERK , a MAP kinase , in the production of TGF-beta by macrophages treated with liposomes composed of phosphatidylserine .
19657566	0	ERK	103,106	TGF-beta	0,8	ERK	TGF-beta	5594	7040	Gene	Gene	pathways|compound|START_ENTITY expression|nmod|pathways promotes|nmod|expression promotes|nsubj|END_ENTITY	TGF-beta promotes invasion and metastasis of gastric_cancer cells by increasing fascin1 expression via ERK and JNK signal pathways .
23583303	0	ERK	86,89	TNF-a	118,123	ERK	TNF-a	5594	7124	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The transcription factor NFAT1 induces apoptosis through cooperation with Ras/Raf/MEK / ERK pathway and upregulation of TNF-a expression .
22556409	0	ERK	106,109	TORC1	174,179	ERK	TORC1	5594	23373	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
22435554	0	ERK	35,38	TPL-2	29,34	ERK	TPL-2	5594	1326	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	IkB kinase regulation of the TPL-2 / ERK MAPK pathway .
25747387	0	ERK	47,50	TRAIL	27,32	ERK	TRAIL	5594	8743	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|advcl|activating	Msi1 confers resistance to TRAIL by activating ERK in liver_cancer cells .
26554024	0	ERK	40,43	TRPC3	0,5	ERK	TRPC3	5594	7222	Gene	Gene	signaling|compound|START_ENTITY amplifies|dobj|signaling amplifies|nsubj|END_ENTITY	TRPC3 amplifies B cell receptor-induced ERK signaling via protein_kinase_D-dependent Rap1 activation .
18717819	0	ERK	104,107	UDP-glucose_dehydrogenase	58,83	ERK	UDP-glucose dehydrogenase	5594	7358	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Epstein-Barr_virus latent membrane protein 2A upregulates UDP-glucose_dehydrogenase gene expression via ERK and PI3K/Akt pathway .
23936001	0	ERK	65,68	VEGF	27,31	ERK	VEGF	5594	7422	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Melittin suppresses HIF-1a / VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical_carcinoma cells .
23135225	0	ERK	61,64	Vaspin	0,6	ERK	Vaspin	5594	145264	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway .
26720469	0	ERK	96,99	ZnT8	76,80	ERK	ZnT8	24338(Tax:10116)	299903(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1a Expression .
19801670	0	ERK	92,95	autocrine_motility_factor	25,50	ERK	autocrine motility factor	5594	2821	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Phosphoglucose_isomerase / autocrine_motility_factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8 .
17211450	0	ERK	38,41	bFGF	25,29	ERK	bFGF	26413(Tax:10090)	14173(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation .
22715588	0	ERK	94,97	bFGF	55,59	ERK	bFGF	5594	2247	Gene	Gene	activation|compound|START_ENTITY blocking|dobj|activation angiogenesis|acl|blocking basic_fibroblast_growth_factor|dep|angiogenesis basic_fibroblast_growth_factor|appos|END_ENTITY	Coenzyme_Q10 decreases basic_fibroblast_growth_factor -LRB- bFGF -RRB- - induced angiogenesis by blocking ERK activation .
16030021	0	ERK	223,226	beta2-adrenergic_receptor	180,205	ERK	beta2-adrenergic receptor	5594	154	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic_receptor to activation of ERK in HEK293B2 cells .
22186412	0	ERK	0,3	c-Raf	23,28	ERK	c-Raf	26413(Tax:10090)	110157(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|dep|END_ENTITY	ERK signaling , but not c-Raf , is required for gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced regulation of Nur77 in pituitary gonadotropes .
12953797	0	ERK	162,165	c-fos	82,87	ERK	c-fos	26413(Tax:10090)	14281(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Suppressive effect of taurine on platelet-derived growth factor -LRB- PDGF -RRB- BB-induced c-fos and c-jun mRNA expressions through extracellular_signal-regulated_kinase -LRB- ERK -RRB- in mesenchymal cell lines .
12540838	0	ERK	11,14	cAMP_response_element-binding_protein	52,89	ERK	cAMP response element-binding protein	5594	1385	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|activity activity|amod|END_ENTITY	Persistent ERK phosphorylation negatively regulates cAMP_response_element-binding_protein -LRB- CREB -RRB- activity via recruitment of CREB-binding_protein to pp90RSK .
16885155	0	ERK	0,3	caspase-3	57,66	ERK	caspase-3	5594	836	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|amod|END_ENTITY	ERK promotes hydrogen_peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells .
20455999	0	ERK	93,96	caveolin-2	137,147	ERK	caveolin-2	5594	858	Gene	Gene	activation|amod|START_ENTITY regulation|nmod|activation regulation|nmod|END_ENTITY	A novel domain of caveolin-2 that controls nuclear targeting : regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2 .
17624368	0	ERK	60,63	connexin43	34,44	ERK	connexin43	5594	2697	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits .
17893107	0	ERK	15,18	cyclin-dependent_kinase_2	47,72	ERK	cyclin-dependent kinase 2	24338(Tax:10116)	362817(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	The map kinase ERK regulates renal activity of cyclin-dependent_kinase_2 in experimental glomerulonephritis .
11319218	0	ERK	18,21	epidermal_growth_factor_receptor	83,115	ERK	epidermal growth factor receptor	5594	1956	Gene	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling required|nmod|downstream downstream|nmod|signaling signaling|compound|END_ENTITY	Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal_growth_factor_receptor signaling .
15572377	0	ERK	8,11	epidermal_growth_factor_receptor	76,108	ERK	epidermal growth factor receptor	2048	1956	Gene	Gene	activation|compound|START_ENTITY reveals|nsubj|activation reveals|dobj|contributions contributions|nmod|END_ENTITY	Parsing ERK activation reveals quantitatively equivalent contributions from epidermal_growth_factor_receptor and HER2 in human mammary epithelial cells .
18174162	0	ERK	62,65	epidermal_growth_factor_receptor	29,61	ERK	epidermal growth factor receptor	13844(Tax:10090)	13649(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	p66shc inhibits pro-survival epidermal_growth_factor_receptor / ERK signaling during severe oxidative stress in mouse renal proximal tubule cells .
19499796	0	ERK	36,39	epidermal_growth_factor_receptor	68,100	ERK	epidermal growth factor receptor	5594	1956	Gene	Gene	simulation|nmod|START_ENTITY signal|nsubj|simulation signal|dep|activated activated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Dynamic simulation and analysis of ERK signal pathway activated by epidermal_growth_factor_receptor -RSB- .
19559020	0	ERK	116,119	epidermal_growth_factor_receptor	15,47	ERK	epidermal growth factor receptor	5594	1956	Gene	Gene	phosphorylation|nmod|START_ENTITY inhibition|nmod|phosphorylation involved|nmod|inhibition involved|nsubjpass|reduction reduction|nmod|END_ENTITY	A reduction of epidermal_growth_factor_receptor is involved in brefelamide-induced inhibition of phosphorylation of ERK in human astrocytoma cells .
20407013	0	ERK	137,140	epidermal_growth_factor_receptor	91,123	ERK	epidermal growth factor receptor	26413(Tax:10090)	13649(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Activation by tyrosine phosphorylation as a prerequisite for protein kinase C to mediate epidermal_growth_factor_receptor signaling to ERK .
20650261	0	ERK	99,102	epidermal_growth_factor_receptor	14,46	ERK	epidermal growth factor receptor	26413(Tax:10090)	13649(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY stimulating|dobj|phosphorylation variant|advcl|stimulating variant|nsubj|effect effect|nmod|END_ENTITY	The effect of epidermal_growth_factor_receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway .
20726858	0	ERK	41,44	epidermal_growth_factor_receptor	61,93	ERK	epidermal growth factor receptor	5594	1956	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nmod|signals signals|compound|END_ENTITY	Amphiregulin regulates the activation of ERK and Akt through epidermal_growth_factor_receptor and HER3 signals involved in the progression of pancreatic_cancer .
22542783	0	ERK	33,36	epidermal_growth_factor_receptor	61,93	ERK	epidermal growth factor receptor	5594	1956	Gene	Gene	activation|nmod|START_ENTITY promotes|dobj|activation promotes|nmod|interaction interaction|nmod|END_ENTITY	Globoside promotes activation of ERK by interaction with the epidermal_growth_factor_receptor .
23549083	0	ERK	92,95	epiregulin	25,35	ERK	epiregulin	26413(Tax:10090)	13874(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Tumor fibroblast-derived epiregulin promotes growth of colitis-associated_neoplasms through ERK .
26125905	0	ERK	112,115	erythropoietin	82,96	ERK	erythropoietin	26413(Tax:10090)	13856(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|acl|activating	Inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells by erythropoietin via activating ERK and P38_MAPK .
20554783	0	ERK	118,121	extracellular-regulated_kinase	86,116	ERK	extracellular-regulated kinase	5594	5594	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Pseudorabies_virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated_kinase -LRB- ERK -RRB- to membranes through interaction with the ERK common docking domain .
9712155	0	ERK	131,134	extracellular-regulated_kinase	99,129	ERK	extracellular-regulated kinase	5594	5594	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Regulation of heregulin beta1-induced differentiation in a human breast_carcinoma cell line by the extracellular-regulated_kinase -LRB- ERK -RRB- pathway .
11299332	0	ERK	57,60	extracellular-signal-regulated_kinase	18,55	ERK	extracellular-signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Ras extracellular-signal-regulated_kinase -LRB- ERK -RRB- mediated signaling promotes ciliary_neurotrophic_factor -LRB- CNTF -RRB- expression in Schwann cells .
12149127	0	ERK	75,78	extracellular-signal-regulated_kinase	80,117	ERK	extracellular-signal-regulated kinase	5594	5594	Gene	Gene	activation|compound|START_ENTITY activation|dep|END_ENTITY	Involvement of phospholipases D1_and_D2 in sphingosine_1-phosphate-induced ERK -LRB- extracellular-signal-regulated_kinase -RRB- activation and interleukin-8 secretion in human bronchial epithelial cells .
15757658	0	ERK	59,62	extracellular-signal-regulated_kinase	20,57	ERK	extracellular-signal-regulated kinase	5594	5594	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Tangeretin inhibits extracellular-signal-regulated_kinase -LRB- ERK -RRB- phosphorylation .
10329108	0	ERK	93,96	extracellular_signal-regulated_kinase	54,91	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Hypertonic_saline induces prostacyclin production via extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
11181896	0	ERK	54,57	extracellular_signal-regulated_kinase	15,52	ERK	extracellular signal-regulated kinase	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of extracellular_signal-regulated_kinase -LRB- ERK -RRB- in pardaxin-induced dopamine release from PC12 cells .
11245462	0	ERK	53,56	extracellular_signal-regulated_kinase	14,51	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells .
12167697	0	ERK	68,71	extracellular_signal-regulated_kinase	29,66	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Rac-PAK signaling stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation by regulating formation of MEK1-ERK complexes .
12854829	0	ERK	58,61	extracellular_signal-regulated_kinase	19,56	ERK	extracellular signal-regulated kinase	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of osteoclast extracellular_signal-regulated_kinase -LRB- ERK -RRB- in cell survival and maintenance of cell polarity .
12855697	0	ERK	73,76	extracellular_signal-regulated_kinase	34,71	ERK	extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Ectopic B-Raf expression enhances extracellular_signal-regulated_kinase -LRB- ERK -RRB- signaling in T cells and prevents antigen-presenting cell-induced anergy .
14570609	0	ERK	50,53	extracellular_signal-regulated_kinase	11,48	ERK	extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of extracellular_signal-regulated_kinase -LRB- ERK -RRB- on focal cerebral_ischemia .
15328055	0	ERK	52,55	extracellular_signal-regulated_kinase	14,51	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of extracellular_signal-regulated_kinase ERK after hypo-osmotic stress in renal epithelial A6 cells .
15341521	0	ERK	53,56	extracellular_signal-regulated_kinase	14,51	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Modulation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity by acute and chronic opioid treatment in neuronal and glial cell lines .
15362698	0	ERK	57,60	extracellular_signal-regulated_kinase	18,55	ERK	extracellular signal-regulated kinase	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Inhibition of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway and the induction of radioresistance in rat_3Y1 cells .
15993506	0	ERK	106,109	extracellular_signal-regulated_kinase	67,104	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	signal|appos|START_ENTITY signal|amod|END_ENTITY	Coxsackievirus B3 replication is related to activation of the late extracellular_signal-regulated_kinase -LRB- ERK -RRB- signal .
17928641	0	ERK	129,132	extracellular_signal-regulated_kinase	90,127	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effect of concomitant stimulation with cholecystokinin and epidermal growth factor on extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in pancreatic acinar cells .
18041576	0	ERK	71,74	extracellular_signal-regulated_kinase	32,69	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Drug-induced alterations in the extracellular_signal-regulated_kinase -LRB- ERK -RRB- signalling pathway : implications for reinforcement and reinstatement .
18562239	0	ERK	57,60	extracellular_signal-regulated_kinase	18,55	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	The regulation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- in mammalian cells .
19110010	0	ERK	53,56	extracellular_signal-regulated_kinase	14,51	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- signaling participates in repression of nuclear factor -LRB- NF -RRB- - kappaB activity by glucocorticoids .
19581021	0	ERK	162,165	extracellular_signal-regulated_kinase	123,160	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Vascular smooth muscle cells promote endothelial cell adhesion via microtubule dynamics and activation of paxillin and the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway in a co-culture system .
20811813	0	ERK	161,164	extracellular_signal-regulated_kinase	122,159	ERK	extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Leukocyte_common_antigen-related _ -LRB- LAR -RRB- _ tyrosine_phosphatase positively regulates osteoblast differentiation by modulating extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
21062576	0	ERK	57,60	extracellular_signal-regulated_kinase	18,55	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The alteration of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity of COS7 cells from interphase to mitosis .
21074569	0	ERK	53,56	extracellular_signal-regulated_kinase	14,51	ERK	extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity with SL327 does not prevent acquisition , expression , and extinction of ethanol-seeking behavior in mice .
21376032	0	ERK	104,107	extracellular_signal-regulated_kinase	65,102	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	An anticancer agent icaritin induces sustained activation of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway and inhibits growth of breast_cancer cells .
21454669	0	ERK	120,123	extracellular_signal-regulated_kinase	81,118	ERK	extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Wnt5a-dopamine_D2_receptor interactions regulate dopamine neuron development via extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
22884480	0	ERK	71,74	extracellular_signal-regulated_kinase	32,69	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Potential opposite roles of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway in autism spectrum and bipolar_disorders .
23782834	0	ERK	170,173	extracellular_signal-regulated_kinase	131,168	ERK	extracellular signal-regulated kinase	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	The Role of fibroblast_growth_factor_receptor_substrate_2 -LRB- FRS2 -RRB- in the regulation of two activity levels of the components of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway in the mouse epididymis .
23935097	0	ERK	158,161	extracellular_signal-regulated_kinase	119,156	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A highly selective dual insulin_receptor -LRB- IR -RRB- / insulin-like growth factor 1 receptor -LRB- IGF-1R -RRB- inhibitor derived from an extracellular_signal-regulated_kinase -LRB- ERK -RRB- inhibitor .
24371145	0	ERK	124,127	extracellular_signal-regulated_kinase	85,122	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	complexes|appos|START_ENTITY complexes|amod|END_ENTITY	Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 -LRB- PP5 -RRB- extracellular_signal-regulated_kinase -LRB- ERK -RRB- complexes involved in the feedback regulation of Raf1 .
24653683	0	ERK	48,51	extracellular_signal-regulated_kinase	9,46	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Neuronal extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity as marker and mediator of alcohol and opioid_dependence .
24948065	0	ERK	114,117	extracellular_signal-regulated_kinase	75,112	ERK	extracellular signal-regulated kinase	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effect of active and passive intravenous cocaine administration on the extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in the rat brain .
25118288	0	ERK	138,141	extracellular_signal-regulated_kinase	99,136	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
26026341	0	ERK	170,173	extracellular_signal-regulated_kinase	131,168	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Thymic stromal lymphopoietin downregulates filaggrin expression by signal_transducer_and __ activator_of_transcription_3 -LRB- STAT3 -RRB- and extracellular_signal-regulated_kinase -LRB- ERK -RRB- phosphorylation in keratinocytes .
8170999	0	ERK	57,60	extracellular_signal-regulated_kinase	18,55	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	requirement|appos|START_ENTITY requirement|nmod|END_ENTITY	A requirement for extracellular_signal-regulated_kinase -LRB- ERK -RRB- function in the activation of AP-1 by Ha-Ras , phorbol_12-myristate_13-acetate , and serum .
9432981	0	ERK	109,112	extracellular_signal-regulated_kinase	70,107	ERK	extracellular signal-regulated kinase	5594	5594	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
11108803	0	ERK	66,69	extracellular_signal-regulated_protein_kinase	19,64	ERK	extracellular signal-regulated protein kinase	5594	5594	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Involvement of the extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- pathway in the induction of apoptosis by cadmium_chloride in CCRF-CEM cells .
12742123	0	ERK	192,195	extracellular_signal-regulated_protein_kinase	145,190	ERK	extracellular signal-regulated protein kinase	5594	5594	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Application of multiplexed capillary electrophoresis with laser-induced fluorescence -LRB- MCE-LIF -RRB- detection for the rapid measurement of endogenous extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- levels in cell extracts .
16865246	0	ERK	70,73	extracellular_signal-regulated_protein_kinase	23,68	ERK	extracellular signal-regulated protein kinase	5594	5594	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Selective reduction of extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- phosphorylation in squamous_cell_carcinoma of the larynx .
19167979	0	ERK	55,58	extracellular_signal-regulated_protein_kinase	8,53	ERK	extracellular signal-regulated protein kinase	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- in 17beta-estradiol-mediated attenuation of lung_injury after trauma-hemorrhage .
15452854	0	ERK	72,75	extracellular_signal-related_kinase	35,70	ERK	extracellular signal-related kinase	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Experience-dependent activation of extracellular_signal-related_kinase -LRB- ERK -RRB- in the olfactory bulb .
12160213	0	ERK	70,73	extracellular_signal_regulated_kinase	31,68	ERK	extracellular signal regulated kinase	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Midkine inhibits apoptosis via extracellular_signal_regulated_kinase -LRB- ERK -RRB- activation in PC12 cells .
16254105	0	ERK	57,60	extracellular_signal_regulated_kinase	18,55	ERK	extracellular signal regulated kinase	5594	5594	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Activation of the extracellular_signal_regulated_kinase -LRB- ERK -RRB- pathway in human melanoma .
22678786	0	ERK	59,62	glucosylceramide_synthase	11,36	ERK	glucosylceramide synthase	5594	7357	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of glucosylceramide_synthase on P-gp expression by ERK signal transduction pathway in leukemia multi-drug resistance cell line -RSB- .
20812005	0	ERK	85,88	gonadotrophin-releasing_hormone	39,70	ERK	gonadotrophin-releasing hormone	5594	2796	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Using high-content microscopy to study gonadotrophin-releasing_hormone regulation of ERK .
11083862	0	ERK	77,80	gonadotropin-releasing_hormone	84,114	ERK	gonadotropin-releasing hormone	5594	2796	Gene	Gene	activation|nmod|START_ENTITY kinase|dobj|activation kinase|nmod|END_ENTITY	Role of dynamin , Src , and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing_hormone .
22186412	0	ERK	0,3	gonadotropin-releasing_hormone	46,76	ERK	gonadotropin-releasing hormone	26413(Tax:10090)	14714(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling required|nmod|END_ENTITY	ERK signaling , but not c-Raf , is required for gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced regulation of Nur77 in pituitary gonadotropes .
16214041	0	ERK	103,106	heme_oxygenase-1	40,56	ERK	heme oxygenase-1	26413(Tax:10090)	15368(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY macrophages|nmod|pathways upregulate|nmod|macrophages upregulate|dobj|expression expression|amod|END_ENTITY	HMG-CoA reductase inhibitors upregulate heme_oxygenase-1 expression in murine RAW264 .7 macrophages via ERK , p38_MAPK and protein kinase G pathways .
17467702	0	ERK	59,62	heme_oxygenase-1	24,40	ERK	heme oxygenase-1	5594	3162	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Triphlorethol-A induces heme_oxygenase-1 via activation of ERK and NF-E2_related_factor_2 transcription factor .
22144097	0	ERK	50,53	heme_oxygenase-1	102,118	ERK	heme oxygenase-1	24338(Tax:10116)	24451(Tax:10116)	Gene	Gene	apoptosis|nmod|START_ENTITY apoptosis|nmod|END_ENTITY	Ampelopsin inhibits H ___ O - induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme_oxygenase-1 .
22147269	0	ERK	54,57	heme_oxygenase-1	16,32	ERK	heme oxygenase-1	24338(Tax:10116)	24451(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of heme_oxygenase-1 by acteoside through ERK and PI3_K / Akt pathway confer neuroprotection against beta-amyloid-induced neurotoxicity .
22466441	0	ERK	56,59	heme_oxygenase-1	21,37	ERK	heme oxygenase-1	5594	3162	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Ferulic_acid induces heme_oxygenase-1 via activation of ERK and Nrf2 .
23073806	0	ERK	125,128	heme_oxygenase-1	102,118	ERK	heme oxygenase-1	24338(Tax:10116)	24451(Tax:10116)	Gene	Gene	inducing|nmod|START_ENTITY inducing|xcomp|END_ENTITY	1,2,3,4,6-penta-O-galloyl-b-D-glucose protects PC12 Cells from MPP -LRB- + -RRB- - mediated cell death by inducing heme_oxygenase-1 in an ERK - and Akt-dependent manner .
11231586	0	ERK	0,3	hnRNP-K	55,62	ERK	hnRNP-K	5594	3190	Gene	Gene	phosphorylation|compound|START_ENTITY drives|nsubj|phosphorylation drives|dobj|accumulation accumulation|nmod|END_ENTITY	ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation .
19880579	0	ERK	45,48	hnRNP-K	0,7	ERK	hnRNP-K	5594	3190	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation .
22197135	0	ERK	107,110	iNOS	94,98	ERK	iNOS	5594	4843	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|compound|END_ENTITY	A concise synthesis of viscolin , and its anti-inflammatory effects through the suppression of iNOS , COX-2 , ERK phosphorylation and proinflammatory cytokines expressions .
20883667	0	ERK	29,32	interleukin-1b	61,75	ERK	interleukin-1b	5594	3553	Gene	Gene	START_ENTITY|xcomp|signaling signaling|nmod|effects effects|nmod|production production|amod|END_ENTITY	Analysis of isoform specific ERK signaling on the effects of interleukin-1b on COX-2 expression and PGE2 production in human chondrocytes .
19066310	0	ERK	13,16	leptin	79,85	ERK	leptin	24338(Tax:10116)	25608(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin .
21849669	0	ERK	92,95	mDia1	40,45	ERK	mDia1	5594	13367(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK , ERK , p38 , and MLC motogenic signals in human Caco-2 intestinal epithelial cells .
22265866	0	ERK	146,149	mTOR	186,190	ERK	mTOR	5594	21977(Tax:10090)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathways in the dorsal hippocampus .
20427710	0	ERK	60,63	mTORC1	41,47	ERK	mTORC1	5594	382056(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Phosphatidic_acid mediates activation of mTORC1 through the ERK signaling pathway .
12490006	0	ERK	88,91	matrix_metalloproteinase-9	18,44	ERK	matrix metalloproteinase-9	26413(Tax:10090)	17395(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of matrix_metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain_injury .
15854510	0	ERK	91,94	matrix_metalloproteinase-9	45,71	ERK	matrix metalloproteinase-9	26413(Tax:10090)	17395(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY stimulates|nmod|pathway stimulates|dobj|production production|amod|END_ENTITY	-LSB- Transforming_growth_factor-beta1 stimulates matrix_metalloproteinase-9 production through ERK activation pathway and upregulation of Ets-1 protein -RSB- .
17114644	0	ERK	104,107	matrix_metalloproteinase-9	37,63	ERK	matrix metalloproteinase-9	5594	4318	Gene	Gene	Ras/Raf/MEK|dep|START_ENTITY suppresses|nmod|Ras/Raf/MEK suppresses|dobj|activation activation|amod|END_ENTITY	Ascofuranone suppresses PMA-mediated matrix_metalloproteinase-9 gene activation through the Ras/Raf/MEK / ERK - and Ap1-dependent mechanisms .
19371720	0	ERK	108,111	matrix_metalloproteinase-9	41,67	ERK	matrix metalloproteinase-9	5594	4318	Gene	Gene	pathways|compound|START_ENTITY cells|nmod|pathways induces|nmod|cells induces|dobj|expression expression|amod|END_ENTITY	Transforming growth factor-beta1 induces matrix_metalloproteinase-9 expression in human meningeal cells via ERK and Smad pathways .
25724188	0	ERK	109,112	matrix_metalloproteinase-9	14,40	ERK	matrix metalloproteinase-9	5594	4318	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|Activation Activation|nmod|MMP-9 MMP-9|amod|END_ENTITY	Activation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by neurotensin promotes cell invasion and migration through ERK pathway in gastric_cancer .
22648654	0	ERK	50,53	microRNA-20a	16,28	ERK	microRNA-20a	5594	406982	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells .
21084841	0	ERK	91,94	mitogen-activated_protein_kinase_phosphatase-2	33,79	ERK	mitogen-activated protein kinase phosphatase-2	5594	1846	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Post-translational regulation of mitogen-activated_protein_kinase_phosphatase-2 -LRB- MKP-2 -RRB- by ERK .
25598203	0	ERK	62,65	mkp-1	56,61	ERK	mkp-1	24338(Tax:10116)	114856(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Exposure to 900MHz electromagnetic fields activates the mkp-1 / ERK pathway and causes blood-brain barrier damage and cognitive_impairment in rats .
19125410	0	ERK	92,95	monocyte_chemoattractant_protein-1	43,77	ERK	monocyte chemoattractant protein-1	24338(Tax:10116)	24770(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Reciprocal regulation of ATPgammaS-induced monocyte_chemoattractant_protein-1 production by ERK and p38 MAP kinases in rat corticostriatal slice cultures .
20384770	0	ERK	24,27	monocyte_chemoattractant_protein-1	92,126	ERK	monocyte chemoattractant protein-1	24338(Tax:10116)	24770(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY critical|nsubj|activation critical|nmod|production production|amod|END_ENTITY	Sustained activation of ERK signaling in astrocytes is critical for neuronal_injury-induced monocyte_chemoattractant_protein-1 production in rat corticostriatal slice cultures .
17241271	0	ERK	95,98	neurofibromatosis_type_1	40,64	ERK	neurofibromatosis type 1	26413(Tax:10090)	18015(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Restored plasticity in a mouse model of neurofibromatosis_type_1 via inhibition of hyperactive ERK and CREB .
24963635	0	ERK	56,59	osteopontin	36,47	ERK	osteopontin	5594	6696	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Cell stress induces upregulation of osteopontin via the ERK pathway in type II alveolar epithelial cells .
20526801	0	ERK	0,3	p21_activated_kinase-1	18,40	ERK	p21 activated kinase-1	5594	5058	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	ERK activation of p21_activated_kinase-1 -LRB- Pak1 -RRB- is critical for medulloblastoma cell migration .
15930308	0	ERK	40,43	p27Kip1	128,135	ERK	p27Kip1	5594	1027	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|expression expression|nmod|END_ENTITY	Pharmacologic inhibition of RAF -- > MEK -- > ERK signaling elicits pancreatic_cancer cell cycle arrest through induced expression of p27Kip1 .
11331872	0	ERK	0,3	p35	12,15	ERK	p35	24338(Tax:10116)	116671(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	ERK induces p35 , a neuron-specific activator of Cdk5 , through induction of Egr1 .
18956431	0	ERK	30,33	p38	49,52	ERK	p38	5594	1432	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nsubj|activation	Stretch-induced activation of ERK in myocytes is p38 and calcineurin-dependent .
25236495	0	ERK	108,111	p38	78,81	ERK	p38	5594	5594	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|pathway pathway|amod|END_ENTITY	MDA-7 / IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis .
11821415	0	ERK	0,3	p53	90,93	ERK	p53	5594	7157	Gene	Gene	activation|compound|START_ENTITY mediates|nsubj|activation mediates|nmod|damage damage|nmod|END_ENTITY	ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53 .
12439598	0	ERK	27,30	p53	80,83	ERK	p53	5594	7157	Gene	Gene	activation|nmod|START_ENTITY induces|nsubj|activation induces|dobj|death death|nmod|END_ENTITY	Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines .
15363324	0	ERK	95,98	p53	47,50	ERK	p53	5594	7157	Gene	Gene	pathways|compound|START_ENTITY pathways|dep|expression expression|dep|END_ENTITY	-LSB- Overexpression of HER2/neu downregulates wild p53 protein expression via PI3K and Ras/Raf/MEK / ERK pathways in human breast_cancer cells -RSB- .
15880691	0	ERK	53,56	p53	182,185	ERK	p53	5594	7157	Gene	Gene	extracellular_signal_regulated_kinase|appos|START_ENTITY Inhibition|nmod|extracellular_signal_regulated_kinase leads|nsubj|Inhibition leads|parataxis|mediated mediated|nsubj|lack lack|nmod|effect effect|nmod|ERK ERK|nmod|END_ENTITY	Inhibition of extracellular_signal_regulated_kinase -LRB- ERK -RRB- leads to apoptosis_inducing_factor -LRB- AIF -RRB- mediated apoptosis in epithelial breast_cancer cells : the lack of effect of ERK in p53 mediated copper induced apoptosis .
16410143	0	ERK	109,112	p53	114,117	ERK	p53	5594	7157	Gene	Gene	correlates|nmod|START_ENTITY correlates|appos|expression expression|compound|END_ENTITY	Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK , p53 expression , and signaling response to U0126 .
17208232	0	ERK	14,17	p53	0,3	ERK	p53	5594	7157	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	p53 regulates ERK activation in carboplatin induced apoptosis_in_cervical_carcinoma : a novel target of p53 in apoptosis .
17208232	0	ERK	14,17	p53	103,106	ERK	p53	5594	7157	Gene	Gene	activation|compound|START_ENTITY activation|nmod|carboplatin carboplatin|acl|induced induced|dobj|apoptosis_in_cervical_carcinoma apoptosis_in_cervical_carcinoma|dep|target target|nmod|END_ENTITY	p53 regulates ERK activation in carboplatin induced apoptosis_in_cervical_carcinoma : a novel target of p53 in apoptosis .
18796294	0	ERK	0,3	p53	37,40	ERK	p53	26413(Tax:10090)	22060(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|compound|END_ENTITY	ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death .
26956619	0	ERK	0,3	p53	68,71	ERK	p53	5594	7157	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|overcomes overcomes|dobj|lack lack|nmod|functionality functionality|compound|END_ENTITY	ERK mediated upregulation of death_receptor_5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon_cancer models : efficiency of DAT1 in Ras-Raf mutated cells .
10753946	0	ERK	36,39	paxillin	19,27	ERK	paxillin	26413(Tax:10090)	19303(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4_thymoma cells .
23986500	0	ERK	0,3	phosphodiesterase_4	18,37	ERK	phosphodiesterase 4	5594	5141	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	ERK regulation of phosphodiesterase_4 enhances dopamine-stimulated AMPA receptor membrane insertion .
15723799	0	ERK	30,33	receptor_tyrosine_kinase	58,82	ERK	receptor tyrosine kinase	3354888(Tax:7227)	38559(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Ras-independent activation of ERK signaling via the torso receptor_tyrosine_kinase is mediated by Rap1 .
22238460	0	ERK	111,114	stem_cell_antigen-1	91,110	ERK	stem cell antigen-1	26413(Tax:10090)	110454(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem_cell_antigen-1 / ERK pathway .
26212545	0	ERK	80,83	transketolase	49,62	ERK	transketolase	5594	7086	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate_carcinoma cells .
21988805	0	ERK	103,106	tyrosinase	62,72	ERK	tyrosinase	26413(Tax:10090)	22173(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38_MAPK signaling pathways .
10733912	0	ERK	77,80	vascular_endothelial_growth_factor	24,58	ERK	vascular endothelial growth factor	5594	7422	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Different regulation of vascular_endothelial_growth_factor expression by the ERK and p38 kinase pathways in v-ras , v-raf , and v-myc transformed cells .
21263382	0	ERK	98,101	vascular_endothelial_growth_factor	49,83	ERK	vascular endothelial growth factor	26413(Tax:10090)	22339(Tax:10090)	Gene	Gene	-|compound|START_ENTITY stem|nmod|- stem|dobj|production production|compound|END_ENTITY	IL-6 and TGF-a costimulate mesenchymal stem cell vascular_endothelial_growth_factor production by ERK - , JNK - , and PI3K-mediated mechanisms .
17251187	0	ERK	86,89	vimentin	15,23	ERK	vimentin	5594	7431	Gene	Gene	MAP|compound|START_ENTITY activation|nmod|MAP assembly|nmod|activation assembly|compound|END_ENTITY	Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis .
12937136	0	ERK-1	32,37	ERK-2	38,43	ERK-1	ERK-2	5595	5594	Gene	Gene	START_ENTITY|dep|activation activation|compound|END_ENTITY	Extra-cellular signal-regulated ERK-1 / ERK-2 pathway activation in human salivary_gland_mucoepidermoid_carcinoma : association to aggressive_tumor behavior and tumor cell proliferation .
12937136	0	ERK-2	38,43	ERK-1	32,37	ERK-2	ERK-1	5594	5595	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|dep|activation	Extra-cellular signal-regulated ERK-1 / ERK-2 pathway activation in human salivary_gland_mucoepidermoid_carcinoma : association to aggressive_tumor behavior and tumor cell proliferation .
19555684	0	ERK-2	41,46	Extracellular_signal-regulated_kinase_2	0,39	ERK-2	Extracellular signal-regulated kinase 2	5594	5594	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Extracellular_signal-regulated_kinase_2 -LRB- ERK-2 -RRB- mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein , RASSF2 .
7998998	0	ERK-2	172,177	extracellular-signal-regulated_kinase-2	131,170	ERK-2	extracellular-signal-regulated kinase-2	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Protein kinase C-dependent cyclic_AMP formation in airway smooth muscle : the role of type_II_adenylate_cyclase and the blockade of extracellular-signal-regulated_kinase-2 -LRB- ERK-2 -RRB- activation .
7969157	0	ERK-3	70,75	p97MAPK	32,39	ERK-3	p97MAPK	58840(Tax:10116)	5597	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Cloning and characterization of p97MAPK , a novel human homolog of rat ERK-3 .
19277491	0	ERK1	18,22	EGF_receptor	82,94	ERK1	EGF receptor	26417(Tax:10090)	13649(Tax:10090)	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	Clozapine-induced ERK1 and ERK2 signaling in prefrontal cortex is mediated by the EGF_receptor .
23211593	0	ERK1	67,71	Insulin-like_growth_factor-1	0,28	ERK1	Insulin-like growth factor-1	5595	3479	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells .
23211593	0	ERK1	67,71	MUC8	37,41	ERK1	MUC8	5595	100129528	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Insulin-like_growth_factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells .
25303175	0	ERK1	32,36	MiR-21	0,6	ERK1	MiR-21	5595	406991	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	MiR-21 Simultaneously Regulates ERK1 Signaling in HSC Activation and Hepatocyte EMT in Hepatic_Fibrosis .
24793005	0	ERK1	0,4	Nanog	20,25	ERK1	Nanog	5595	79923	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal .
12747800	0	ERK1	63,67	P2X7_receptor	0,13	ERK1	P2X7 receptor	5595	5027	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	P2X7_receptor activates extracellular signal-regulated kinases ERK1 and ERK2 independently of Ca2 + influx .
26041847	0	ERK1	67,71	Tripeptidyl_Peptidase_II	0,24	ERK1	Tripeptidyl Peptidase II	5594	7174	Gene	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	Tripeptidyl_Peptidase_II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2 .
8380983	0	ERK1	36,40	p44mapk	27,34	ERK1	p44mapk	5595	5595	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Differential activation of p44mapk -LRB- ERK1 -RRB- by alpha-thrombin and thrombin-receptor peptide agonist .
23966319	0	ERK1/2	4,10	11beta-hydroxysteroid_dehydrogenase_type_2	39,81	ERK1/2	11beta-hydroxysteroid dehydrogenase type 2	5595;5594	3291	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The ERK1/2 signaling pathway regulates 11beta-hydroxysteroid_dehydrogenase_type_2 expression in human trophoblast cells through a transcriptional mechanism .
17471497	0	ERK1/2	121,127	AP-1	168,172	ERK1/2	AP-1	5595;5594	3725	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2 - and p38 kinase-dependent activation of AP-1 .
17504975	0	ERK1/2	22,28	AP-1	36,40	ERK1/2	AP-1	50689;116590	24516(Tax:10116)	Gene	Gene	START_ENTITY|nmod|factor factor|compound|END_ENTITY	Sequential actions of ERK1/2 on the AP-1 transcription factor allow temporal integration of metabolic signals in pancreatic beta cells .
25450674	0	ERK1/2	76,82	ARF6	12,16	ERK1/2	ARF6	5595;5594	382	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Cytohesin_2 / ARF6 regulates preadipocyte migration through the activation of ERK1/2 .
18842004	0	ERK1/2	55,61	AdipoR1	26,33	ERK1/2	AdipoR1	5595;5594	51094	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth .
17942284	0	ERK1/2	93,99	Akt	110,113	ERK1/2	Akt	5595;5594	207	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	HGF protects cultured cortical neurons against hypoxia/reoxygenation induced cell injury via ERK1/2 and PI-3K / Akt pathways .
24650887	0	ERK1/2	194,200	Akt	214,217	ERK1/2	Akt	26417;26413	11651(Tax:10090)	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
24343777	0	ERK1/2	42,48	Angiotensin-II	0,14	ERK1/2	Angiotensin-II	5595;5594	183	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Angiotensin-II induces phosphorylation of ERK1/2 and promotes aortic adventitial fibroblasts differentiating into myofibroblasts during aortic_dissection formation .
15698454	0	ERK1/2	88,94	Angiotensin_II	0,14	ERK1/2	Angiotensin II	5595;5594	183	Gene	Gene	cells|nmod|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	Angiotensin_II induces fibronectin expression in human peritoneal mesothelial cells via ERK1/2 and p38_MAPK .
16139272	0	ERK1/2	60,66	Angiotensin_II	0,14	ERK1/2	Angiotensin II	50689;116590	24179(Tax:10116)	Gene	Gene	nitration|nmod|START_ENTITY induces|dobj|nitration induces|nsubj|END_ENTITY	Angiotensin_II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells .
16253189	0	ERK1/2	125,131	Angiotensin_II	1,15	ERK1/2	Angiotensin II	5595;5594	183	Gene	Gene	-RSB-|compound|START_ENTITY activation|nmod|-RSB- cells|nmod|activation expression|nmod|cells END_ENTITY|dep|expression	-LSB- Angiotensin_II and aldosterone_stimulate alpha1 - -LRB- I -RRB- procollagen mRNA expression in hepatic stellate cells via activation of ERK1/2 and AP-1 -RSB- .
17380010	0	ERK1/2	92,98	Angiotensin_II	0,14	ERK1/2	Angiotensin II	5595;5594	183	Gene	Gene	formation|nmod|START_ENTITY inhibits|dobj|formation inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits insulin-induced actin stress fiber formation and glucose uptake via ERK1/2 .
20538278	0	ERK1/2	61,67	Angiotensin_II	0,14	ERK1/2	Angiotensin II	5595;5594	183	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces C-reactive_protein expression through ERK1/2 and JNK signaling in human aortic endothelial cells .
21109230	0	ERK1/2	70,76	Angiotensin_II	0,14	ERK1/2	Angiotensin II	26417;26413	11606(Tax:10090)	Gene	Gene	pathway|nummod|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Angiotensin_II induces interleukin-6 synthesis in osteoblasts through ERK1/2 pathway via AT1 receptor .
26379274	0	ERK1/2	115,121	Angiotensin_II	78,92	ERK1/2	Angiotensin II	50689;116590	24179(Tax:10116)	Gene	Gene	Proliferation|nmod|START_ENTITY Proliferation|nmod|END_ENTITY	Exendin-4 Prevents Vascular Smooth Muscle Cell Proliferation and Migration by Angiotensin_II via the Inhibition of ERK1/2 and JNK Signaling Pathways .
15944398	0	ERK1/2	43,49	BPGAP1	63,69	ERK1/2	BPGAP1	5595;5594	23779	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain .
22943143	0	ERK1/2	90,96	Basic_fibroblast_growth_factor	0,30	ERK1/2	Basic fibroblast growth factor	5595;5594	2247	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Basic_fibroblast_growth_factor protects C17 .2 cells from radiation-induced injury through ERK1/2 .
26721325	0	ERK1/2	44,50	Bim	112,115	ERK1/2	Bim	5595;5594	10018	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Pseudorabies_virus glycoprotein gE triggers ERK1/2 phosphorylation and degradation of the pro-apoptotic protein Bim in epithelial cells .
15313431	0	ERK1/2	34,40	C5a	0,3	ERK1/2	C5a	5595;5594	728	Gene	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	C5a differentially stimulates the ERK1/2 and p38_MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264 .7 macrophages .
24155087	0	ERK1/2	68,74	CCN2	27,31	ERK1/2	CCN2	5595;5594	1490	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway .
22086849	0	ERK1/2	0,6	CD44	21,25	ERK1/2	CD44	26417;26413	12505(Tax:10090)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	ERK1/2 regulation of CD44 modulates oral cancer_aggressiveness .
23806693	0	ERK1/2	71,77	CDK-associated_Cullin_1	0,23	ERK1/2	CDK-associated Cullin 1	5595;5594	143384	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	CDK-associated_Cullin_1 promotes cell proliferation with activation of ERK1/2 in human lung_cancer A549 cells .
12472883	0	ERK1/2	100,106	COX-2	13,18	ERK1/2	COX-2	50689;116590	26198(Tax:10116)	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|Induction Induction|nmod|gliosis gliosis|amod|END_ENTITY	Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling .
18958425	0	ERK1/2	64,70	COX-2	44,49	ERK1/2	COX-2	5595;5594	4513	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of lysophosphatidic_acid-induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells .
22210040	0	ERK1/2	80,86	COX-2	13,18	ERK1/2	COX-2	5595;5594	4513	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Acid-induced COX-2 expression and prostaglandin_E2 production via activation of ERK1/2 and p38 MAPK in cultured feline esophageal smooth muscle cells .
24924779	0	ERK1/2	51,57	COX-2	81,86	ERK1/2	COX-2	5595;5594	5743	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Eckols reduce dental_pulp_inflammation through the ERK1/2 pathway independent of COX-2 inhibition .
18329727	0	ERK1/2	45,51	CREB	80,84	ERK1/2	CREB	50689;116590	81646(Tax:10116)	Gene	Gene	level|nmod|START_ENTITY END_ENTITY|nsubj|level	Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture .
19500499	0	ERK1/2	60,66	CTGF	40,44	ERK1/2	CTGF	26417;26413	14219(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY expression|nmod|-RSB- expression|compound|END_ENTITY	-LSB- Losartan inhibits high glucose-induced CTGF expression via ERK1/2 MAPK pathways in mouse mesangial cells -RSB- .
23723373	0	ERK1/2	73,79	CXCR4	102,107	ERK1/2	CXCR4	26417;26413	12767(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	Toll-like_receptor_2-blocking antibodies promote angiogenesis and induce ERK1/2 and AKT signaling via CXCR4 in endothelial cells .
22982089	0	ERK1/2	84,90	Cellular_retinoic_acid_binding_protein_I	0,40	ERK1/2	Cellular retinoic acid binding protein I	5595;5594	1381	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Cellular_retinoic_acid_binding_protein_I mediates rapid non-canonical activation of ERK1/2 by all-trans_retinoic_acid .
25237906	0	ERK1/2	125,131	Connexin32	76,86	ERK1/2	Connexin32	5595;5594	2705	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Tetramethylpyrazine Suppresses Transient Oxygen-Glucose Deprivation-Induced Connexin32 Expression and Cell Apoptosis via the ERK1/2 and p38 MAPK Pathway in Cultured Hippocampal Neurons .
26334722	0	ERK1/2	99,105	Connexin_43	0,11	ERK1/2	Connexin 43	5595;5594	2697	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Connexin_43 promotes ossification_of_the_posterior_longitudinal_ligament through activation of the ERK1/2 and p38 MAPK pathways .
26346493	0	ERK1/2	43,49	DYRK1B	97,103	ERK1/2	DYRK1B	5595;5594	9149	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic_syndrome .
26346493	0	ERK1/2	43,49	DYRK1B	97,103	ERK1/2	DYRK1B	5595;5594	9149	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic_syndrome .
18658095	0	ERK1/2	0,6	EGFR	72,76	ERK1/2	EGFR	5595;5594	1956	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|compound|END_ENTITY	ERK1/2 mediate wounding - and G-protein-coupled receptor ligands-induced EGFR activation via regulating ADAM17 and HB-EGF shedding .
26069273	0	ERK1/2	46,52	ESR1	18,22	ERK1/2	ESR1	5595;5594	2099	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Estrogen receptor ESR1 mediates activation of ERK1/2 , CREB , and ELK1 in the corpus_of_the_epididymis .
12388423	0	ERK1/2	38,44	Endothelin-1	0,12	ERK1/2	Endothelin-1	50689;116590	24323(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction .
17174312	0	ERK1/2	27,33	Epac	0,4	ERK1/2	Epac	5595;5594	10411	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Epac - and Rap - independent ERK1/2 phosphorylation induced by Gs-coupled receptor stimulation in HEK293 cells .
22117074	0	ERK1/2	123,129	Epidermal_growth_factor_receptor	0,32	ERK1/2	Epidermal growth factor receptor	5595;5594	1956	Gene	Gene	epsilon|nmod|START_ENTITY feedback|nmod|epsilon END_ENTITY|dep|feedback	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- - mediated positive feedback of protein-tyrosine phosphatase epsilon -LRB- PTPepsilon -RRB- on ERK1/2 and AKT protein pathways is required for survival of human breast_cancer cells .
23734838	0	ERK1/2	62,68	Epiregulin	0,10	ERK1/2	Epiregulin	5595;5594	2069	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway .
15563472	0	ERK1/2	51,57	Ets1	31,35	ERK1/2	Ets1	5595;5594	2113	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells .
15699632	0	ERK1/2	36,42	Ets1	0,4	ERK1/2	Ets1	5595;5594	2113	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells .
20228268	0	ERK1/2	22,28	Factor_XII	0,10	ERK1/2	Factor XII	26417;26413	58992(Tax:10090)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Factor_XII stimulates ERK1/2 and Akt through uPAR , integrins , and the EGFR to initiate angiogenesis .
25869623	0	ERK1/2	0,6	Fndc5	29,34	ERK1/2	Fndc5	5595;5594	252995	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	ERK1/2 is a key regulator of Fndc5 and PGC1a expression during neural differentiation of mESCs .
21822733	0	ERK1/2	14,20	GAP-43	46,52	ERK1/2	GAP-43	50689;116590	29423(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|compound|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
22761875	0	ERK1/2	71,77	GB1	23,26	ERK1/2	GB1	26417;26413	54393(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation .
21303939	0	ERK1/2	85,91	GPR30	0,5	ERK1/2	GPR30	26417;26413	76854(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY growth|nmod|inhibition opposes|dobj|growth opposes|nsubj|activation activation|compound|END_ENTITY	GPR30 activation opposes estrogen-dependent uterine growth via inhibition of stromal ERK1/2 and estrogen_receptor_alpha -LRB- ERa -RRB- phosphorylation signals .
26371374	0	ERK1/2	85,91	GPR30	107,112	ERK1/2	GPR30	5595;5594	2852	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	The sequence P295-T311 of the hinge region of the estrogen_receptor_a is involved in ERK1/2 activation via GPR30 in leiomyoma cells .
20886089	0	ERK1/2	16,22	GPR54	0,5	ERK1/2	GPR54	26417;26413	114229(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Ga -LRB- q/11 -RRB- and b-arrestin-dependent manner .
16982618	0	ERK1/2	33,39	GRK3	43,47	ERK1/2	GRK3	26417;26413	320129(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nsubj|activation	Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neurons .
19276072	0	ERK1/2	77,83	Galectin-8	0,10	ERK1/2	Galectin-8	5595;5594	3964	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic_acid-mediated ERK1/2 activation supported by protein kinase A down-regulation .
22809535	0	ERK1/2	86,92	Ghrelin	0,7	ERK1/2	Ghrelin	5595;5594	59301(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Ghrelin induces cardiac lineage differentiation of human embryonic stem cells through ERK1/2 pathway .
15277494	0	ERK1/2	94,100	Hepatocyte_growth_factor	0,24	ERK1/2	Hepatocyte growth factor	5595;5594	3082	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces proliferation of lens epithelial cells through activation of ERK1/2 and JNK/SAPK .
19328461	0	ERK1/2	20,26	ICBP90	0,6	ERK1/2	ICBP90	5595;5594	29128	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells .
26835742	0	ERK1/2	69,75	ICER	90,94	ERK1/2	ICER	50689;116590	25620(Tax:10116)	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER .
21822733	0	ERK1/2	14,20	IGF-1	37,42	ERK1/2	IGF-1	50689;116590	24482(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
19946718	0	ERK1/2	70,76	IGF-1R	28,34	ERK1/2	IGF-1R	5595;5594	3480	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2 + - induced ERK1/2 and PKB phosphorylation .
22761875	0	ERK1/2	71,77	IGF-1R	86,92	ERK1/2	IGF-1R	26417;26413	16001(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|transactivation transactivation|compound|END_ENTITY	GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation .
20042461	0	ERK1/2	58,64	IL-17A	0,6	ERK1/2	IL-17A	26417;26413	16171(Tax:10090)	Gene	Gene	pathways|dep|START_ENTITY chemokines|nmod|pathways chemokines|amod|END_ENTITY	IL-17A and IL-17F stimulate chemokines via MAPK pathways -LRB- ERK1/2 and p38 but not JNK -RRB- in mouse cultured mesangial cells : synergy with TNF-alpha and IL-1beta .
21993883	0	ERK1/2	71,77	IL-17A	0,6	ERK1/2	IL-17A	5595;5594	3605	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-17A stimulates granulocyte_colony-stimulating_factor production via ERK1/2 but not p38 or JNK in human renal proximal tubular epithelial cells .
25557204	0	ERK1/2	17,23	IL-17A	0,6	ERK1/2	IL-17A	26417;26413	16171(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	IL-17A activates ERK1/2 and enhances differentiation of oligodendrocyte progenitor cells .
16436473	0	ERK1/2	33,39	IL-1beta	65,73	ERK1/2	IL-1beta	50689;116590	24494(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nmod|END_ENTITY	PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells .
26221267	0	ERK1/2	107,113	IL-37	73,78	ERK1/2	IL-37	5595	27178	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Mannose-capped Lipoarabinomannan from Mycobacterium_tuberculosis induces IL-37 production via upregulating ERK1/2 and p38 in human type II alveolar epithelial cells .
26770645	0	ERK1/2	116,122	IL-37	82,87	ERK1/2	IL-37	5595	27178	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Erratum : Mannose-capped lipoarabinomannan from Mycobacterium_tuberculosis induces IL-37 production via upregulating ERK1/2 and p38 in human type II alveolar epithelial cells .
24650887	0	ERK1/2	194,200	IL-6	138,142	ERK1/2	IL-6	26417;26413	16193(Tax:10090)	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY secretion|amod|p-c-JUN_and_JNK secretion|compound|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
17012372	0	ERK1/2	84,90	IL-8	72,76	ERK1/2	IL-8	5595;5594	3576	Gene	Gene	JNK|appos|START_ENTITY JNK|compound|END_ENTITY	Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8 , IL-6 , ERK1/2 , JNK , and NF-kappaB activation in a cystic fibrosis epithelial cell line .
17498677	0	ERK1/2	8,14	ILK	59,62	ERK1/2	ILK	5595;5594	3611	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells .
15454338	0	ERK1/2	116,122	JNK	75,78	ERK1/2	JNK	5595;5594	26419(Tax:10090)	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase -LRB- JNK -RRB- and extracellular-regulated kinase -LRB- ERK1/2 -RRB- in an experimental model of cerulein-induced pancreatitis .
17690253	0	ERK1/2	89,95	JUNB	66,70	ERK1/2	JUNB	5595;5594	3726	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	The oncoprotein NPM-ALK of anaplastic_large-cell_lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling .
15699632	0	ERK1/2	36,42	K-ras	53,58	ERK1/2	K-ras	5595;5594	3845	Gene	Gene	activated|nmod|START_ENTITY activated|nmod|END_ENTITY	Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells .
26212440	0	ERK1/2	112,118	Kruppel-like_factor_2	0,21	ERK1/2	Kruppel-like factor 2	5595;5594	10365	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	Kruppel-like_factor_2 inhibit the angiogenesis of cultured human liver sinusoidal endothelial cells through the ERK1/2 signaling pathway .
16384560	0	ERK1/2	62,68	Lox-1	77,82	ERK1/2	Lox-1	5595;5594	4973	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1 .
22731636	0	ERK1/2	32,38	Lyn	0,3	ERK1/2	Lyn	5595;5594	4067	Gene	Gene	activation|compound|START_ENTITY involved|nmod|activation involved|nsubjpass|END_ENTITY	Lyn is involved in CD24-induced ERK1/2 activation in colorectal_cancer .
24199952	0	ERK1/2	48,54	MECP2	0,5	ERK1/2	MECP2	5595;5594	4204	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	MECP2 promotes cell proliferation by activating ERK1/2 and inhibiting p38 activity in human hepatocellular_carcinoma HEPG2 cells .
16006144	0	ERK1/2	71,77	MEKK1	0,5	ERK1/2	MEKK1	50689;116590	116667(Tax:10116)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling .
19419315	0	ERK1/2	62,68	MGP	34,37	ERK1/2	MGP	26417;26413	17313(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Phosphate-dependent regulation of MGP in osteoblasts : role of ERK1/2 and Fra-1 .
23771439	0	ERK1/2	58,64	MKP-1	8,13	ERK1/2	MKP-1	50689;116590	114856(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Role of MKP-1 -LRB- DUSP1 -RRB- in clozapine-induced effects on the ERK1/2 signaling pathway in the rat frontal cortex .
16815629	0	ERK1/2	129,135	MMP-2	45,50	ERK1/2	MMP-2	26417;26413	17390(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY line|nmod|pathway inhibits|nmod|line inhibits|dobj|expression expression|compound|END_ENTITY	siRNA targeted against HAb18G/CD147 inhibits MMP-2 secretion , actin and FAK expression in hepatocellular_carcinoma cell line via ERK1/2 pathway .
22211962	0	ERK1/2	154,160	MMP-2	83,88	ERK1/2	MMP-2	5595;5594	4313	Gene	Gene	MAPK|compound|START_ENTITY suppression|nmod|MAPK suppresses|nmod|suppression suppresses|dobj|expression expression|amod|END_ENTITY	The butanol fraction of guava -LRB- Psidium cattleianum Sabine -RRB- leaf extract suppresses MMP-2 and MMP-9 expression and activity through the suppression of the ERK1/2 MAPK signaling pathway .
22282250	0	ERK1/2	59,65	MMP-2	15,20	ERK1/2	MMP-2	5595;5594	4313	Gene	Gene	dependent|nmod|START_ENTITY resistance|amod|dependent END_ENTITY|nmod|resistance	Involvement of MMP-2 in adriamycin resistance dependent on ERK1/2 signal pathway in human osteosarcoma MG-63 cells .
23790167	0	ERK1/2	97,103	MMP-2	121,126	ERK1/2	MMP-2	5595;5594	4313	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	p21-activated_kinase_4 regulation of endometrial_cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion .
25563790	0	ERK1/2	100,106	MMP-2	141,146	ERK1/2	MMP-2	5595;5594	4313	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Nobiletin inhibits invasion and migration of human nasopharyngeal_carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2 .
23671886	0	ERK1/2	4,10	MMP-9	71,76	ERK1/2	MMP-9	50689;116590	81687(Tax:10116)	Gene	Gene	Upregulation|compound|START_ENTITY Upregulation|nmod|END_ENTITY	The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina .
19428994	0	ERK1/2	34,40	Melanocortin_5_receptor	0,23	ERK1/2	Melanocortin 5 receptor	5595;5594	4161	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Melanocortin_5_receptor activates ERK1/2 through a PI3K-regulated signaling mechanism .
23012423	0	ERK1/2	24,30	MiR-494	0,7	ERK1/2	MiR-494	5595;5594	574452	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell_lung_cancer through BIM down-regulation .
26343857	0	ERK1/2	54,60	NFATc1	89,95	ERK1/2	NFATc1	5595;5594	4772	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Insulin enhances RANKL-induced osteoclastogenesis via ERK1/2 activation and induction of NFATc1 and Atp6v0d2 .
23490205	0	ERK1/2	32,38	NRAS	76,80	ERK1/2	NRAS	5595;5594	4893	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS , vemurafenib-resistant melanoma cells .
25911324	0	ERK1/2	85,91	OCT4	0,4	ERK1/2	OCT4	5595;5594	5460	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	OCT4 mediates FSH-induced epithelial-mesenchymal transition and invasion through the ERK1/2 signaling pathway in epithelial_ovarian_cancer .
15722198	0	ERK1/2	76,82	P2Y2	53,57	ERK1/2	P2Y2	50689;116590	29597(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	Effects of extracellular nucleotides in the thyroid : P2Y2 receptor-mediated ERK1/2 activation and c-Fos induction in PC Cl3 cells .
15046862	0	ERK1/2	57,63	PACAP	0,5	ERK1/2	PACAP	50689;116590	24166(Tax:10116)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	PACAP activates Rac1 and synergizes with NGF to activate ERK1/2 , thereby inducing neurite outgrowth in PC12 cells .
15569628	0	ERK1/2	8,14	PCNA	30,34	ERK1/2	PCNA	50689;116590	25737(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of ERK1/2 in FSH induced PCNA expression and steroidogenesis in granulosa cells .
16406609	0	ERK1/2	63,69	PI3K	0,4	ERK1/2	PI3K	5595;5594	5293	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation .
21387274	0	ERK1/2	152,158	PI3K	118,122	ERK1/2	PI3K	5595;5594	5293	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Limitations in small_intestinal_neuroendocrine_tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT .
26033591	0	ERK1/2	26,32	PI3K	15,19	ERK1/2	PI3K	5595;5594	5293	Gene	Gene	MAPK|dobj|START_ENTITY MAPK|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of PI3K , MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine .
25391900	0	ERK1/2	87,93	PKC-a	0,5	ERK1/2	PKC-a	5595;5594	5578	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	PKC-a contributes to high NaCl-induced activation of NFAT5 -LRB- TonEBP/OREBP -RRB- through MAPK ERK1/2 .
14749212	0	ERK1/2	65,71	PKC-delta_and_CaMKII-delta_2	0,28	ERK1/2	PKC-delta and CaMKII-delta 2	5595;5594	5580	Gene	Gene	activation|nmod|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	PKC-delta_and_CaMKII-delta_2 mediate ATP-dependent activation of ERK1/2 in vascular smooth muscle .
9395450	0	ERK1/2	60,66	PKC-epsilon	0,11	ERK1/2	PKC-epsilon	5595;5594	5581	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells .
12581866	0	ERK1/2	22,28	PKC_epsilon	0,11	ERK1/2	PKC epsilon	26417;26413	18754(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|dep|activation	PKC_epsilon - mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells .
18534741	0	ERK1/2	67,73	PKC_epsilon	14,25	ERK1/2	PKC epsilon	5595;5594	5581	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of PKC_epsilon induces lactotroph proliferation through ERK1/2 in response to phorbol_ester .
21076047	0	ERK1/2	58,64	PTEN	8,12	ERK1/2	PTEN	5595;5594	5728	Gene	Gene	permits|nmod|START_ENTITY permits|nsubj|Loss Loss|nmod|END_ENTITY	Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate_cancer cells .
22737980	0	ERK1/2	19,25	PTEN	0,4	ERK1/2	PTEN	5595;5594	5728	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	PTEN regulation of ERK1/2 signaling in cancer .
19384851	0	ERK1/2	88,94	Parathyroid_hormone	0,19	ERK1/2	Parathyroid hormone	50689;116590	24694(Tax:10116)	Gene	Gene	kinase|acl|START_ENTITY phosphorylation|nmod|kinase inhibits|dobj|phosphorylation inhibits|nsubj|END_ENTITY	Parathyroid_hormone inhibits phosphorylation of mitogen-activated protein kinase -LRB- MAPK -RRB- ERK1/2 through inhibition of c-Raf and activation of MKP-1 in osteoblastic cells .
16849556	0	ERK1/2	100,106	Proepithelin	0,12	ERK1/2	Proepithelin	5595;5594	2896	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Proepithelin promotes migration and invasion of 5637 bladder_cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex .
20693286	0	ERK1/2	63,69	Protein_kinase_B	0,16	ERK1/2	Protein kinase B	5595;5594	2185	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Protein_kinase_B -LRB- AKT -RRB- mediates phospholipase_D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells .
15046862	0	ERK1/2	57,63	Rac1	16,20	ERK1/2	Rac1	50689;116590	363875(Tax:10116)	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	PACAP activates Rac1 and synergizes with NGF to activate ERK1/2 , thereby inducing neurite outgrowth in PC12 cells .
25381666	0	ERK1/2	205,211	Raf-1	199,204	ERK1/2	Raf-1	5595;5594	5894	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Co-culture system of human salivary gland epithelial cells and immune cells from primary Sj gren 's syndrome patients : an in vitro approach to study the effects of Rituximab on the activation of the Raf-1 / ERK1/2 pathway .
26437446	0	ERK1/2	142,148	Raf-1	165,170	ERK1/2	Raf-1	50689;116590	24703(Tax:10116)	Gene	Gene	pathways|nummod|START_ENTITY pathways|nmod|level level|amod|kinase kinase|amod|END_ENTITY	Hydroxyflutamide affects connexin_43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells .
26201295	0	ERK1/2	101,107	Rap2B	0,5	ERK1/2	Rap2B	5595;5594	5912	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Rap2B promotes proliferation , migration , and invasion of human breast_cancer through calcium-related ERK1/2 signaling pathway .
26201295	0	ERK1/2	101,107	Rap2B	0,5	ERK1/2	Rap2B	5595;5594	5912	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Rap2B promotes proliferation , migration , and invasion of human breast_cancer through calcium-related ERK1/2 signaling pathway .
25907296	0	ERK1/2	94,100	S100A9	0,6	ERK1/2	S100A9	5595;5594	6280	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	S100A9 promotes human hepatocellular_carcinoma cell growth and invasion through RAGE-mediated ERK1/2 and p38 MAPK pathways .
26795953	0	ERK1/2	41,47	STAT1	58,63	ERK1/2	STAT1	5595;5594	6772	Gene	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts .
15115615	0	ERK1/2	0,6	STAT3	42,47	ERK1/2	STAT3	5595;5594	6774	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|activity activity|nummod|END_ENTITY	ERK1/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells .
24819473	0	ERK1/2	92,98	STAT3	63,68	ERK1/2	STAT3	26417;26413	20848(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K .
19151362	0	ERK1/2	78,84	Stat3	38,43	ERK1/2	Stat3	50689;116590	25125(Tax:10116)	Gene	Gene	cardiomyocytes|nmod|START_ENTITY END_ENTITY|nmod|cardiomyocytes	Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2 : role of sphingosine-1-phosphate .
21480396	0	ERK1/2	157,163	Stat3	126,131	ERK1/2	Stat3	26417;26413	20848(Tax:10090)	Gene	Gene	involve|nmod|START_ENTITY involve|nsubj|radiation radiation|nmod|END_ENTITY	Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C with Stat3 involve integration with ERK1/2 .
16926552	0	ERK1/2	92,98	THP-1	72,77	ERK1/2	THP-1	5595;5594	2736	Gene	Gene	monocytes|nmod|START_ENTITY monocytes|compound|END_ENTITY	Urokinase induces matrix_metalloproteinase-9 / gelatinase B expression in THP-1 monocytes via ERK1/2 and cytosolic phospholipase A2 activation and eicosanoid production .
18239851	0	ERK1/2	84,90	TRAIL	0,5	ERK1/2	TRAIL	5595;5594	8743	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2 .
23222305	0	ERK1/2	13,19	TWIST1	0,6	ERK1/2	TWIST1	5595;5594	7291	Gene	Gene	effector|compound|START_ENTITY effector|nsubj|END_ENTITY	TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells .
21172820	0	ERK1/2	47,53	TbetaRII	106,114	ERK1/2	TbetaRII	5595;5594	7048	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|levels levels|nmod|expression expression|compound|END_ENTITY	TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression .
21172820	0	ERK1/2	47,53	TbetaRII	25,33	ERK1/2	TbetaRII	5595;5594	7048	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression .
24161842	0	ERK1/2	0,6	Trib1	28,33	ERK1/2	Trib1	26417;26413	211770(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	ERK1/2 regulates hepatocyte Trib1 in response to mitochondrial_dysfunction .
20564184	0	ERK1/2	59,65	Tumor_necrosis_factor_alpha	0,27	ERK1/2	Tumor necrosis factor alpha	5595;5594	7124	Gene	Gene	activation|nummod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells .
12503613	0	ERK1/2	22,28	Urotensin_II	0,12	ERK1/2	Urotensin II	5595;5594	10911	Gene	Gene	phosphorylation|compound|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Urotensin_II mediates ERK1/2 phosphorylation and proliferation in GPR14-transfected cell lines .
19839874	0	ERK1/2	55,61	VEGF	73,77	ERK1/2	VEGF	5595;5594	7422	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Impact of the transfer of sFlt-1 gene fragments on the ERK1/2 pathway of VEGF in vitro .
21455573	0	ERK1/2	77,83	VEGF-A	0,6	ERK1/2	VEGF-A	5595;5594	7422	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	VEGF-A not Ang2 mediates endothelial-like differentiation of immature DCs by ERK1/2 signaling in the microenvironment of human colon_adenocarcinoma .
21945543	0	ERK1/2	53,59	Visfatin	0,8	ERK1/2	Visfatin	50689;116590	297508(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway .
22114204	0	ERK1/2	50,56	WNK4	0,4	ERK1/2	WNK4	26417;26413	69847(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway .
22647544	0	ERK1/2	55,61	WNT-5A	35,41	ERK1/2	WNT-5A	26417;26413	22418(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation .
23727359	0	ERK1/2	47,53	WNT-5A	0,6	ERK1/2	WNT-5A	5595;5594	7474	Gene	Gene	dependent|advmod|START_ENTITY decrease|amod|dependent triggers|nmod|decrease triggers|nsubj|END_ENTITY	WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast_cancer cells .
20710016	0	ERK1/2	63,69	adipophilin	43,54	ERK1/2	adipophilin	26417;26413	11520(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY activates|nmod|pathway activates|dobj|END_ENTITY	Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264 .7 cells .
15459207	0	ERK1/2	0,6	alpha-enolase	50,63	ERK1/2	alpha-enolase	50689;116590	24333(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic_hypoxia and reoxygenation .
12837293	0	ERK1/2	83,89	amyloid_precursor_protein	14,39	ERK1/2	amyloid precursor protein	5595;5594	351	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of amyloid_precursor_protein expression and secretion via activation of ERK1/2 by hepatocyte_growth_factor in HEK293 cells transfected with APP751 .
20874728	0	ERK1/2	87,93	androgen_receptor	57,74	ERK1/2	androgen receptor	50689;116590	24208(Tax:10116)	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|compound|END_ENTITY	The anti-oestrogen fulvestrant -LRB- ICI_182 ,780 -RRB- reduces the androgen_receptor expression , ERK1/2 phosphorylation and cell proliferation in the rat ventral prostate .
14755545	0	ERK1/2	0,6	angiotensin_II	130,144	ERK1/2	angiotensin II	50689;116590	24179(Tax:10116)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	ERK1/2 and JNKs , but not p38 kinase , are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin_II and interleukin-1beta in adult rat cardiac fibroblasts .
15775784	0	ERK1/2	112,118	angiotensin_II	137,151	ERK1/2	angiotensin II	5595;5594	183	Gene	Gene	responsiveness|nummod|START_ENTITY role|nmod|responsiveness role|nmod|END_ENTITY	Angiotensin_II-induced over-activation of p47phox in fibroblasts from hypertensives : which role in the enhanced ERK1/2 responsiveness to angiotensin_II ?
15921682	0	ERK1/2	0,6	angiotensin_II	21,35	ERK1/2	angiotensin II	50689;116590	24179(Tax:10116)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	ERK1/2 activation by angiotensin_II inhibits insulin-induced glucose uptake in vascular smooth muscle cells .
17763940	0	ERK1/2	115,121	angiotensin_II	56,70	ERK1/2	angiotensin II	50689;116590	24179(Tax:10116)	Gene	Gene	kinases|compound|START_ENTITY role|nmod|kinases Regulation|dep|role Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of c-fos , c-jun and c-myc gene expression by angiotensin_II in primary cultured rat astrocytes : role of ERK1/2 MAP kinases .
17952409	0	ERK1/2	39,45	angiotensin_II	14,28	ERK1/2	angiotensin II	50689;116590	24179(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of angiotensin_II and IV on ERK1/2 and CREB signalling in cultured rat astroglial cells .
18083124	0	ERK1/2	21,27	angiotensin_II	50,64	ERK1/2	angiotensin II	5595;5594	183	Gene	Gene	activation|nummod|START_ENTITY activation|acl|induced induced|nmod|END_ENTITY	Roscovitine inhibits ERK1/2 activation induced by angiotensin_II in vascular smooth muscle cells .
19041135	0	ERK1/2	69,75	angiotensin_II	27,41	ERK1/2	angiotensin II	26417;26413	11606(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY induced|dobj|phosphorylation END_ENTITY|acl|induced	Angiotensin - -LRB- 1-7 -RRB- enhances angiotensin_II induced phosphorylation of ERK1/2 in mouse bone marrow-derived dendritic cells .
9045626	0	ERK1/2	60,66	angiotensin_II	31,45	ERK1/2	angiotensin II	50689;116590	24179(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|dobj|activation	Protein_kinase_C-zeta mediates angiotensin_II activation of ERK1/2 in vascular smooth muscle cells .
9440699	0	ERK1/2	54,60	angiotensin_II	65,79	ERK1/2	angiotensin II	26417;26413	11606(Tax:10090)	Gene	Gene	kinases|appos|START_ENTITY kinases|nmod|END_ENTITY	Activation of extracellular signal-regulated kinases -LRB- ERK1/2 -RRB- by angiotensin_II is dependent on c-Src in vascular smooth muscle cells .
26400984	0	ERK1/2	41,47	c-Abl	34,39	ERK1/2	c-Abl	5595;5594	25	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|amod|END_ENTITY	MicroRNA-203 negatively regulates c-Abl , ERK1/2 phosphorylation , and proliferation in smooth muscle cells .
19384851	0	ERK1/2	88,94	c-Raf	117,122	ERK1/2	c-Raf	50689;116590	24703(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Parathyroid_hormone inhibits phosphorylation of mitogen-activated protein kinase -LRB- MAPK -RRB- ERK1/2 through inhibition of c-Raf and activation of MKP-1 in osteoblastic cells .
16873684	0	ERK1/2	0,6	cAMP-responsive_element-binding_protein	52,91	ERK1/2	cAMP-responsive element-binding protein	50689;116590	81646(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	ERK1/2 control phosphorylation and protein level of cAMP-responsive_element-binding_protein : a key role in glucose-mediated pancreatic beta-cell survival .
19195865	0	ERK1/2	62,68	caveolin-1	36,46	ERK1/2	caveolin-1	5595;5594	857	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells .
17707346	0	ERK1/2	116,122	early_growth_response_gene_1	14,42	ERK1/2	early growth response gene 1	5595;5594	1958	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of early_growth_response_gene_1 and interleukin-8 expression by ribotoxin deoxynivalenol -LRB- vomitoxin -RRB- via ERK1/2 in human epithelial intestine_407 cells .
24071787	0	ERK1/2	53,59	epidermal_growth_factor_receptor	76,108	ERK1/2	epidermal growth factor receptor	50689;116590	24329(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY facilitates|dobj|activation facilitates|nmod|END_ENTITY	Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal_growth_factor_receptor in rat granulosa cells .
24566221	0	ERK1/2	164,170	epidermal_growth_factor_receptor	50,82	ERK1/2	epidermal growth factor receptor	50689;116590	24329(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY decreases|nmod|activation decreases|nsubj|transactivation transactivation|nmod|END_ENTITY	b-Adrenergic receptor-mediated transactivation of epidermal_growth_factor_receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt .
20298757	0	ERK1/2	97,103	extracellular_signal-regulated_kinase_1_and_2	50,95	ERK1/2	extracellular signal-regulated kinase 1 and 2	50689;116590	50689;116590	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression and extracellular_signal-regulated_kinase_1_and_2 -LRB- ERK1/2 -RRB- activation in exercise-reduced neuronal apoptosis after stroke .
9242621	0	ERK1/2	103,109	extracellular_signal-regulated_kinase_1_or_2	57,101	ERK1/2	extracellular signal-regulated kinase 1 or 2	50689;116590	50689;116590	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Pituitary_adenylyl_cyclase-activating_peptide stimulates extracellular_signal-regulated_kinase_1_or_2 -LRB- ERK1/2 -RRB- activity in a Ras-independent , mitogen-activated protein Kinase/ERK kinase 1 or 2-dependent manner in PC12 cells .
10092829	0	ERK1/2	87,93	extracellular_signal-regulated_kinases_1_and_2	39,85	ERK1/2	extracellular signal-regulated kinases 1 and 2	5595;5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Implication of TNF receptor-I-mediated extracellular_signal-regulated_kinases_1_and_2 -LRB- ERK1/2 -RRB- activation in growth of AIDS-associated Kaposi 's _ sarcoma cells : a possible role of a novel death domain protein MADD in TNF-alpha-induced ERK1/2 activation in Kaposi 's _ sarcoma cells .
21993883	0	ERK1/2	71,77	granulocyte_colony-stimulating_factor	18,55	ERK1/2	granulocyte colony-stimulating factor	5595;5594	1440	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	IL-17A stimulates granulocyte_colony-stimulating_factor production via ERK1/2 but not p38 or JNK in human renal proximal tubular epithelial cells .
12837293	0	ERK1/2	83,89	hepatocyte_growth_factor	93,117	ERK1/2	hepatocyte growth factor	5595;5594	3082	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of amyloid_precursor_protein expression and secretion via activation of ERK1/2 by hepatocyte_growth_factor in HEK293 cells transfected with APP751 .
16436473	0	ERK1/2	33,39	iNOS	57,61	ERK1/2	iNOS	50689;116590	24599(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells .
16697690	0	ERK1/2	55,61	interleukin-8	13,26	ERK1/2	interleukin-8	5595;5594	3576	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Induction of interleukin-8 secretion and activation of ERK1/2 , p38 MAPK signaling pathways by thrombin in dermal fibroblasts .
22955917	0	ERK1/2	129,135	mTORC1	79,85	ERK1/2	mTORC1	5595;5594	382056(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Targeting NAD + salvage pathway induces autophagy in multiple_myeloma cells via mTORC1 and extracellular signal-regulated kinase -LRB- ERK1/2 -RRB- inhibition .
15180997	0	ERK1/2	90,96	matrix_metalloproteinase_9	16,42	ERK1/2	matrix metalloproteinase 9	5595;5594	4318	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Calcium-induced matrix_metalloproteinase_9 gene expression is differentially regulated by ERK1/2 and p38 MAPK in oral keratinocytes and oral_squamous_cell_carcinoma .
24441545	0	ERK1/2	81,87	p27kip1	117,124	ERK1/2	p27kip1	50689;116590	83571(Tax:10116)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1 .
14667935	0	ERK1/2	84,90	p38	45,48	ERK1/2	p38	5595;5594	5594	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|regulation regulation|nmod|END_ENTITY	Adenosine_A3_receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3 ' - kinase .
16535835	0	ERK1/2	105,111	p38	94,97	ERK1/2	p38	50689;116590	81649(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effect on apoptosis of anterior pituitary induced by cadmium_chloride and its relations with p38 MAPK _ ERK1/2 passway -RSB- .
20428768	0	ERK1/2	105,111	p38	131,134	ERK1/2	p38	5595;5594	5594	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast_cancer cells .
24650887	0	ERK1/2	194,200	p38	209,212	ERK1/2	p38	26417;26413	26416(Tax:10090)	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
17533378	0	ERK1/2	75,81	p38_MAPK	95,103	ERK1/2	p38 MAPK	26417;26413	26416(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Indirubin-3 ' - monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38_MAPK .
16492667	0	ERK1/2	101,107	parathyroid_hormone	61,80	ERK1/2	parathyroid hormone	5595;5594	5741	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Distinct beta-arrestin - and G protein-dependent pathways for parathyroid_hormone receptor-stimulated ERK1/2 activation .
17038311	0	ERK1/2	146,152	parathyroid_hormone	27,46	ERK1/2	parathyroid hormone	5595;5594	5741	Gene	Gene	beta-arrestin2|nmod|START_ENTITY c-Src|nmod|beta-arrestin2 activation|amod|c-Src scaffolding|nmod|activation mediate|dobj|scaffolding terminus|xcomp|mediate motifs|parataxis|terminus motifs|nmod|END_ENTITY	Proline-rich motifs in the parathyroid_hormone -LRB- PTH -RRB- / PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation .
22414806	0	ERK1/2	108,114	parathyroid_hormone	14,33	ERK1/2	parathyroid hormone	5595;5594	5741	Gene	Gene	MAPK|compound|START_ENTITY activation|nsubj|MAPK prolongs|xcomp|activation prolongs|nsubj|Disruption Disruption|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Disruption of parathyroid_hormone and parathyroid_hormone-related peptide receptor phosphorylation prolongs ERK1/2 MAPK activation and enhances c-fos expression .
20693286	0	ERK1/2	63,69	phospholipase_D	32,47	ERK1/2	phospholipase D	5595;5594	2822	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Protein_kinase_B -LRB- AKT -RRB- mediates phospholipase_D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells .
14644771	0	ERK1/2	128,134	plasminogen_activator_inhibitor-1	79,112	ERK1/2	plasminogen activator inhibitor-1	5595;5594	5054	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|acl|activating	Increased vascular_endothelial_growth_factor may account for elevated level of plasminogen_activator_inhibitor-1 via activating ERK1/2 in keloid fibroblasts .
19699794	0	ERK1/2	14,20	protein_kinase_C-alpha	24,46	ERK1/2	protein kinase C-alpha	5595;5594	5578	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of ERK1/2 by protein_kinase_C-alpha in response to hydrogen_peroxide-induced cell death in human gingival fibroblasts .
21256191	0	ERK1/2	20,26	sphingosine_1-phosphate	49,72	ERK1/2	sphingosine 1-phosphate	26417;26413	13609(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|acl|induced induced|nmod|END_ENTITY	Redox regulation of ERK1/2 activation induced by sphingosine_1-phosphate in fibroblasts : involvement of NADPH oxidase and platelet-derived growth factor receptor .
20979115	0	ERK1/2	82,88	stat3	41,46	ERK1/2	stat3	5595;5594	6774	Gene	Gene	receptors|compound|START_ENTITY cells|nmod|receptors activate|nmod|cells activate|dobj|END_ENTITY	HDL and sphingosine-1-phosphate activate stat3 in prostate_cancer DU145 cells via ERK1/2 and S1P receptors , and promote cell migration and invasion .
17452987	0	ERK1/2	27,33	steroidogenic_acute_regulatory_protein	71,109	ERK1/2	steroidogenic acute regulatory protein	5595;5594	6770	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nmod|END_ENTITY	Human adipocytes induce an ERK1/2 MAP kinases-mediated upregulation of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- and an angiotensin_II-sensitization in human adrenocortical cells .
23844043	0	ERK1/2	26,32	thrombomodulin	52,66	ERK1/2	thrombomodulin	5595;5594	7056	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	UVB irradiation regulates ERK1/2 - and p53-dependent thrombomodulin expression in human keratinocytes .
16957308	0	ERK2	23,27	ERK2	68,72	ERK2	ERK2	5594	5594	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Periodic activation of ERK2 and partial involvement of G protein in ERK2 activation by cAMP in Dictyostelium cells .
16957308	0	ERK2	68,72	ERK2	23,27	ERK2	ERK2	5594	5594	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Periodic activation of ERK2 and partial involvement of G protein in ERK2 activation by cAMP in Dictyostelium cells .
18178562	0	ERK2	102,106	Epidermal_growth_factor_receptor	0,32	ERK2	Epidermal growth factor receptor	5594	1956	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Epidermal_growth_factor_receptor and protein_kinase_C signaling to ERK2 : spatiotemporal regulation of ERK2 by dual specificity phosphatases .
18178562	0	ERK2	67,71	Epidermal_growth_factor_receptor	0,32	ERK2	Epidermal growth factor receptor	5594	1956	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Epidermal_growth_factor_receptor and protein_kinase_C signaling to ERK2 : spatiotemporal regulation of ERK2 by dual specificity phosphatases .
17332341	0	ERK2	114,118	GATA-1	0,6	ERK2	GATA-1	5594	2623	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells .
10702794	0	ERK2	15,19	HePTP	80,85	ERK2	HePTP	5594	5786	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP .
21325828	0	ERK2	22,26	Hsp70	92,97	ERK2	Hsp70	26413(Tax:10090)	15511(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role for ERK2 in anoxia-induced activation of transcription and translation of Hsp70 in NIH 3T3 cells .
14970219	0	ERK2	13,17	IQGAP1	0,6	ERK2	IQGAP1	5594	8826	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	IQGAP1 binds ERK2 and modulates its activity .
10619403	0	ERK2	72,76	Leptin	0,6	ERK2	Leptin	26413(Tax:10090)	16846(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2 .
11239467	0	ERK2	114,118	MKP-3	62,67	ERK2	MKP-3	5594	1848	Gene	Gene	activation|nmod|START_ENTITY insights|nmod|activation structure|dep|insights structure|nmod|domain domain|nmod|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
11239467	0	ERK2	114,118	MKP-3	94,99	ERK2	MKP-3	5594	1848	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
11239467	0	ERK2	22,26	MKP-3	62,67	ERK2	MKP-3	5594	1848	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
11239467	0	ERK2	22,26	MKP-3	94,99	ERK2	MKP-3	5594	1848	Gene	Gene	domain|compound|START_ENTITY structure|nmod|domain structure|dep|insights insights|nmod|activation activation|compound|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
9596579	0	ERK2	49,53	MKP-3	40,45	ERK2	MKP-3	5594	1848	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase .
12177807	0	ERK2	34,38	MMP-9	48,53	ERK2	MMP-9	5594	4318	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|secretion secretion|compound|END_ENTITY	Integrin alpha -LRB- v -RRB- beta6-associated ERK2 mediates MMP-9 secretion in colon_cancer cells .
21618303	0	ERK2	47,51	MUC5B	26,31	ERK2	MUC5B	5594	727897	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Diallyl_disulfide induces MUC5B expression via ERK2 in human airway epithelial cells .
25975246	0	ERK2	72,76	MUC8	26,30	ERK2	MUC8	5594	100129528	Gene	Gene	expressions|nmod|START_ENTITY expressions|compound|END_ENTITY	Asian_sand_dust increases MUC8 and MUC5B expressions via TLR4-dependent ERK2 and p38 MAPK in human airway epithelial cells .
20353787	0	ERK2	40,44	MnSOD	13,18	ERK2	MnSOD	5594	6648	Gene	Gene	translocation|compound|START_ENTITY END_ENTITY|nmod|translocation	ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells .
15924567	0	ERK2	97,101	NFkappaB	108,116	ERK2	NFkappaB	5594	4790	Gene	Gene	cascade|compound|START_ENTITY cascade|compound|END_ENTITY	17beta-oestradiol up-regulates longevity-related , antioxidant enzyme expression via the ERK1 and ERK2 -LSB- MAPK -RSB- / NFkappaB cascade .
12220502	0	ERK2	6,10	Naf1	28,32	ERK2	Naf1	5594	92345	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A new ERK2 binding protein , Naf1 , attenuates the EGF/ERK2 nuclear signaling .
17244536	0	ERK2	52,56	PARP-1	16,22	ERK2	PARP-1	5594	142	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity : a link to histone acetylation .
15485655	0	ERK2	21,25	SNT-2	0,5	ERK2	SNT-2	5594	10817	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation .
9692677	0	ERK2	0,4	epidermal_growth_factor_receptor	34,66	ERK2	epidermal growth factor receptor	5594	1956	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	ERK2 signalling from internalised epidermal_growth_factor_receptor in broken A431 cells .
15883033	0	ERK2	73,77	iNOS	35,39	ERK2	iNOS	116590(Tax:10116)	24599(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	AP-1 mediates beta-amyloid-induced iNOS expression in PC12 cells via the ERK2 and p38_MAPK signaling pathways .
16188240	0	ERK2	80,84	macrophage_migration_inhibitory_factor	37,75	ERK2	macrophage migration inhibitory factor	26413(Tax:10090)	17319(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY END_ENTITY|nmod|activation	Ursolic_acid promotes the release of macrophage_migration_inhibitory_factor via ERK2 activation in resting mouse macrophages .
14551204	0	ERK2	71,75	mitogen-activated_protein_kinase_phosphatase_1	93,139	ERK2	mitogen-activated protein kinase phosphatase 1	5594	1843	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Jak2 tyrosine kinase mediates angiotensin_II-dependent inactivation of ERK2 via induction of mitogen-activated_protein_kinase_phosphatase_1 .
9705360	0	ERK2	57,61	p21	80,83	ERK2	p21	5594	1026	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21 -LRB- cip1 -RRB- .
19477952	0	ERK2/1	32,38	caveolin-1	118,128	ERK2/1	caveolin-1	5594;5595	857	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial cell caveolae : a paradoxical role of caveolin-1 in placental angiogenesis in vitro .
8954940	0	ERK3	26,30	B-Raf	36,41	ERK3	B-Raf	58840(Tax:10116)	114486(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	A specific association of ERK3 with B-Raf in rat hippocampus .
16597486	0	ERK3	0,4	MAP2	21,25	ERK3	MAP2	58840(Tax:10116)	25595(Tax:10116)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion .
25351247	0	ERK5	37,41	ALK	11,14	ERK5	ALK	5598	238	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma .
17003042	0	ERK5	44,48	Brain-derived_neurotrophic_factor	0,33	ERK5	Brain-derived neurotrophic factor	114509(Tax:10116)	24225(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade .
20200162	0	ERK5	82,86	G_protein-coupled_receptors	101,128	ERK5	G protein-coupled receptors	23939(Tax:10090)	227289(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	G_alpha -LRB- q -RRB- acts as an adaptor protein in protein kinase C zeta -LRB- PKCzeta -RRB- - mediated ERK5 activation by G_protein-coupled_receptors -LRB- GPCR -RRB- .
14978743	0	ERK5	45,49	MEKK2	0,5	ERK5	MEKK2	23939(Tax:10090)	26405(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts .
12042304	0	ERK5	58,62	PTP-SL	37,43	ERK5	PTP-SL	5598	5801	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway .
18588859	0	ERK5	19,23	TGF-beta	0,8	ERK5	TGF-beta	5598	7040	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TGF-beta activates ERK5 in human renal epithelial cells .
14681216	0	ERK5	15,19	WNK1	0,4	ERK5	WNK1	5598	65125	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	WNK1 activates ERK5 by an MEKK2/3-dependent mechanism .
26739108	0	ERK5	0,4	ankrd1	13,19	ERK5	ankrd1	114509(Tax:10116)	27064(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells .
17018293	0	ERK5	38,42	c-Fos	29,34	ERK5	c-Fos	5598	2353	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Spatiotemporal regulation of c-Fos by ERK5 and the E3_ubiquitin_ligase UBR1 , and its biological role .
20628425	0	ERK5	56,60	endothelin-1	16,28	ERK5	endothelin-1	114509(Tax:10116)	24323(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats .
19858097	0	ERK5	74,78	extracellular_signal-regulated_kinase_5	33,72	ERK5	extracellular signal-regulated kinase 5	5598	5598	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	The signaling pathway leading to extracellular_signal-regulated_kinase_5 -LRB- ERK5 -RRB- activation via G-proteins and ERK5-dependent neurotrophic effects .
17275785	0	ERK5	14,18	insulin	22,29	ERK5	insulin	5598	3630	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells .
12628002	0	ERK5	102,106	mitogen-activated_protein_kinase_kinase_5	111,152	ERK5	mitogen-activated protein kinase kinase 5	5598	5607	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	An analysis of the phosphorylation and activation of extracellular-signal-regulated_protein_kinase_5 -LRB- ERK5 -RRB- by mitogen-activated_protein_kinase_kinase_5 -LRB- MKK5 -RRB- in vitro .
15132737	0	ERK5	0,4	myocyte_enhancer_factor_2A	20,46	ERK5	myocyte enhancer factor 2A	5598	4205	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	ERK5 is targeted to myocyte_enhancer_factor_2A -LRB- MEF2A -RRB- through a MAPK docking motif .
15149851	0	ERM	8,11	moesin	29,35	ERM	moesin	326152(Tax:7227)	4478	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Nuclear ERM -LRB- ezrin , radixin , moesin -RRB- proteins : regulation by cell density and nuclear import .
19592131	0	ERM	55,58	moesin	68,74	ERM	moesin	326152(Tax:7227)	31816(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Live imaging reveals that the Drosophila actin-binding ERM protein , moesin , co-localizes with the mitotic spindle .
18822397	0	ERR	74,77	ERRalpha	94,102	ERR	ERRalpha	6541	2101	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Conserved properties of a urochordate estrogen receptor-related receptor -LRB- ERR -RRB- with mammalian ERRalpha .
23208510	0	ERR	10,13	PGC-1	4,9	ERR	PGC-1	6541	10891	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	The PGC-1 / ERR signaling axis in cancer .
17509876	0	ERR	51,54	estrogen-related_receptor	24,49	ERR	estrogen-related receptor	6541	6541	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical implication of estrogen-related_receptor -LRB- ERR -RRB- expression in ovarian_cancers .
19416752	0	ERR	51,54	estrogen-related_receptor	24,49	ERR	estrogen-related receptor	6541	6541	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical implication of estrogen-related_receptor -LRB- ERR -RRB- expression in uterine endometrial_cancers .
9256346	0	ERR-1	47,52	estrogen-related_receptor_1	18,45	ERR-1	estrogen-related receptor 1	26379(Tax:10090)	26379(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Expression of the estrogen-related_receptor_1 -LRB- ERR-1 -RRB- orphan receptor during mouse development .
12772780	0	ERRP	44,48	EGF-receptor	14,26	ERRP	EGF-receptor	24329(Tax:10116)	24329(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|protein protein|amod|END_ENTITY	Expression of EGF-receptor related protein -LRB- ERRP -RRB- decreases in gastric mucosa during aging and carcinogenesis .
15327841	0	ERRP	64,68	epidermal_growth_factor-receptor_related_protein	14,62	ERRP	epidermal growth factor-receptor related protein	64285	64285	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor-receptor_related_protein -LRB- ERRP -RRB- in human colorectal_carcinogenesis .
24425001	0	ERRa	0,4	HIF-1	14,19	ERRa	HIF-1	2101	3091	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|END_ENTITY	ERRa augments HIF-1 signalling by directly interacting with HIF-1a in normoxic and hypoxic prostate_cancer cells .
26804918	0	ERRa	11,15	PGC-1a	4,10	ERRa	PGC-1a	2101	10891	Gene	Gene	Metabolism|compound|START_ENTITY END_ENTITY|dep|Metabolism	The PGC-1a / ERRa Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast_Cancer .
25480584	0	ERRa	44,48	estrogen-related_receptor_alpha	11,42	ERRa	estrogen-related receptor alpha	2101	2101	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of estrogen-related_receptor_alpha -LRB- ERRa -RRB- on proliferation and metastasis of human lung_cancer A549 cells .
23680656	0	ERRa	45,49	osteopontin	21,32	ERRa	osteopontin	2101	6696	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Control of the human osteopontin promoter by ERRa in colorectal_cancer .
18822397	0	ERRalpha	94,102	ERR	74,77	ERRalpha	ERR	2101	6541	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Conserved properties of a urochordate estrogen receptor-related receptor -LRB- ERR -RRB- with mammalian ERRalpha .
16314495	0	ERRalpha	76,84	PDK4	23,27	ERRalpha	PDK4	2101	5166	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha : a mechanism for transcriptional control of muscle glucose metabolism .
16623704	0	ERRalpha	18,26	PDK4	85,89	ERRalpha	PDK4	2101	5166	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|partner partner|nmod|PGC-1alpha PGC-1alpha|nmod|activation activation|nmod|expression expression|compound|END_ENTITY	Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle .
15087503	0	ERRalpha	37,45	PGC-1alpha	90,100	ERRalpha	PGC-1alpha	2101	10891	Gene	Gene	functions|appos|START_ENTITY functions|appos|END_ENTITY	The estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- functions in PPARgamma coactivator 1alpha -LRB- PGC-1alpha -RRB- - induced mitochondrial biogenesis .
15184675	0	ERRalpha	105,113	PGC-1alpha	44,54	ERRalpha	PGC-1alpha	2101	10891	Gene	Gene	ligand|appos|START_ENTITY signaling|nmod|ligand END_ENTITY|acl|signaling	Regulation of PPARgamma coactivator 1alpha -LRB- PGC-1alpha -RRB- signaling by an estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- ligand .
16314495	0	ERRalpha	76,84	PGC-1alpha	0,10	ERRalpha	PGC-1alpha	2101	10891	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha : a mechanism for transcriptional control of muscle glucose metabolism .
16623704	0	ERRalpha	18,26	PGC-1alpha	52,62	ERRalpha	PGC-1alpha	2101	10891	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|partner partner|nmod|END_ENTITY	Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle .
18673300	0	ERRalpha	55,63	PGC-1alpha	0,10	ERRalpha	PGC-1alpha	2101	10891	Gene	Gene	nucleosome|compound|START_ENTITY induces|nmod|nucleosome induces|nsubj|END_ENTITY	PGC-1alpha induces dynamic protein interactions on the ERRalpha gene multi-hormone response element nucleosome in kidney cells .
20101261	0	ERRalpha	93,101	UCP1	111,115	ERRalpha	UCP1	2101	7350	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	Human fetal mesenchymal stem cells differentiate into brown and white adipocytes : a role for ERRalpha in human UCP1 expression .
15184675	0	ERRalpha	105,113	estrogen-related_receptor_alpha	72,103	ERRalpha	estrogen-related receptor alpha	2101	2101	Gene	Gene	ligand|appos|START_ENTITY ligand|amod|END_ENTITY	Regulation of PPARgamma coactivator 1alpha -LRB- PGC-1alpha -RRB- signaling by an estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- ligand .
17294452	0	ERRalpha	57,65	estrogen-related_receptor_alpha	24,55	ERRalpha	estrogen-related receptor alpha	2101	2101	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- is a negative prognostic predictor in human prostate_cancer .
20923753	0	ERRb	46,50	estrogen-related_receptor_beta	14,44	ERRb	estrogen-related receptor beta	2103	2103	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of estrogen-related_receptor_beta -LRB- ERRb -RRB- in human skin .
16314306	0	ERRgamma	108,116	DAX-1	59,64	ERRgamma	DAX-1	2104	190	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRgamma .
14651967	0	ERRgamma	99,107	PNRC2	18,23	ERRgamma	PNRC2	2104	55629	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma .
18573717	0	ERRgamma	47,55	estrogen-related_receptor_gamma	14,45	ERRgamma	estrogen-related receptor gamma	2104	2104	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of estrogen-related_receptor_gamma -LRB- ERRgamma -RRB- in human skin .
25807177	0	ERRy	106,110	Hypoxia-inducible_factor-1a	0,27	ERRy	Hypoxia-inducible factor-1a	2104	3091	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|nsubj|END_ENTITY	Hypoxia-inducible_factor-1a upregulates tyrosine hydroxylase and dopamine_transporter by nuclear receptor ERRy in SH-SY5Y cells .
10692254	0	ERV-3	64,69	env	70,73	ERV-3	env	2086	30816	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model , BeWo .
9458354	0	ERV3	42,46	HERV-R	48,54	ERV3	HERV-R	2086	2086	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of human endogenous retrovirus ERV3 -LRB- HERV-R -RRB- mRNA in normal and neoplastic tissues .
10427470	0	ERV3	115,119	env	71,74	ERV3	env	2086	30816	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3 .
11713212	0	ER_alpha	29,37	ER_beta	16,23	ER alpha	ER beta	24890(Tax:10116)	25149(Tax:10116)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Coexpression of ER_beta with ER_alpha and progestin receptor proteins in the female rat forebrain : effects of estradiol treatment .
12532908	0	ER_alpha	231,239	cyclin_D1	189,198	ER alpha	cyclin D1	2099	595	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	-LSB- Invasive_ductal_carcinoma of the breast : study of the number of copies of the CCND1 gene and chromosome 11 using fluorescence in situ hybridization -LRB- FISH -RRB- in comparison with expression of cyclin_D1 protein and estrogen_receptors -LRB- ER_alpha -RRB- with immunohistochemical detection -RSB- .
12733715	0	ER_alpha	84,92	estrogen_receptor_alpha	59,82	ER alpha	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel splicing events of untranslated first exons in human estrogen_receptor_alpha -LRB- ER_alpha -RRB- gene .
11713212	0	ER_beta	16,23	ER_alpha	29,37	ER beta	ER alpha	25149(Tax:10116)	24890(Tax:10116)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Coexpression of ER_beta with ER_alpha and progestin receptor proteins in the female rat forebrain : effects of estradiol treatment .
21292825	0	ERa	43,46	AIB1	8,12	ERa	AIB1	13982(Tax:10090)	76960(Tax:10090)	Gene	Gene	effects|compound|START_ENTITY impacts|dobj|effects END_ENTITY|parataxis|impacts	Altered AIB1 or AIB1 / \ 3 expression impacts ERa effects on mammary gland stromal and epithelial content .
22550166	0	ERa	5,8	AIB1	0,4	ERa	AIB1	2099	116833	Gene	Gene	activity|compound|START_ENTITY enhanced|nsubjpass|activity END_ENTITY|parataxis|enhanced	AIB1 : ERa transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast_cancer cells .
23762395	0	ERa	21,24	AIB1	0,4	ERa	AIB1	26284	63897	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	AIB1 cooperates with ERa to promote epithelial mesenchymal transition in breast_cancer through SNAI1 activation .
25178514	0	ERa	21,24	AR	0,2	ERa	AR	2099	367	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	AR collaborates with ERa in aromatase inhibitor-resistant breast_cancer .
23296636	0	ERa	0,3	ATGL	47,51	ERa	ATGL	13982(Tax:10090)	66853(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	ERa regulates lipid metabolism in bone through ATGL and perilipin .
26821020	0	ERa	0,3	BRMS1	89,94	ERa	BRMS1	2099	25855	Gene	Gene	START_ENTITY|dobj|Expression Expression|nmod|END_ENTITY	ERa Mediates Estrogen-Induced Expression of the Breast Cancer Metastasis Suppressor Gene BRMS1 .
23178685	0	ERa	23,26	CAC1	46,50	ERa	CAC1	26284	113452	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Negative regulation of ERa by a novel protein CAC1 through association with histone demethylase LSD1 .
22975348	0	ERa	0,3	DNMT1	25,30	ERa	DNMT1	2099	1786	Gene	Gene	regulated|nsubj|START_ENTITY regulated|dobj|expression expression|compound|END_ENTITY	ERa positively regulated DNMT1 expression by binding to the gene promoter region in human breast_cancer MCF-7 cells .
26389696	0	ERa	9,12	E3_Ubiquitin_Ligase	28,47	ERa	E3 Ubiquitin Ligase	2099	158506	Gene	Gene	Stimulates|nsubj|START_ENTITY Stimulates|dobj|Activity Activity|amod|END_ENTITY	Liganded ERa Stimulates the E3_Ubiquitin_Ligase Activity of UBE3C to Facilitate Cell Proliferation .
24816249	0	ERa	108,111	ERa	80,83	ERa	ERa	2099	2099	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERa expression in initially ERa + breast_cancer cells .
24816249	0	ERa	80,83	ERa	108,111	ERa	ERa	2099	2099	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERa expression in initially ERa + breast_cancer cells .
23860318	0	ERa	120,123	ERb	131,134	ERa	ERb	2099	2100	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERa and/or ERb transactivation .
27041579	0	ERa	21,24	FOXC1	0,5	ERa	FOXC1	2099	2296	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	FOXC1 is involved in ERa silencing by counteracting GATA3 binding and is implicated in endocrine resistance .
27018308	0	ERa	55,58	HOXB13	75,81	ERa	HOXB13	2099	10481	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	Tumor-associated macrophage-derived CXCL8 could induce ERa suppression via HOXB13 in endometrial_cancer .
25531331	0	ERa	18,21	MiR-873	0,7	ERa	MiR-873	2099	100126316	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	MiR-873 regulates ERa transcriptional activity and tamoxifen resistance via targeting CDK3 in breast_cancer cells .
26202215	0	ERa	18,21	MiR-873	0,7	ERa	MiR-873	26284	100126316	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	MiR-873 regulates ERa transcriptional activity and tamoxifen resistance via targeting CDK3 in breast_cancer cells .
26202215	0	ERa	18,21	MiR-873	0,7	ERa	MiR-873	26284	100126316	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	MiR-873 regulates ERa transcriptional activity and tamoxifen resistance via targeting CDK3 in breast_cancer cells .
22820289	0	ERa	57,60	PES1	0,4	ERa	PES1	2099	23481	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	PES1 promotes breast_cancer by differentially regulating ERa and ERb .
24376209	0	ERa	48,51	PES1	0,4	ERa	PES1	26284	23481	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PES1 differentially regulates the expression of ERa and ERb in ovarian_cancer .
25161887	0	ERa	0,3	Phd3	16,20	ERa	Phd3	2099	112399	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	ERa upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue .
26183411	0	ERa	33,36	Progesterone_Receptor	0,21	ERa	Progesterone Receptor	26284	5241	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Progesterone_Receptor Determines ERa Function .
26153859	0	ERa	32,35	Progesterone_receptor	0,21	ERa	Progesterone receptor	26284	5241	Gene	Gene	action|compound|START_ENTITY modulates|dobj|action modulates|nsubj|END_ENTITY	Progesterone_receptor modulates ERa action in breast_cancer .
26245370	0	ERa	45,48	Progesterone_receptor	13,34	ERa	Progesterone receptor	26284	5241	Gene	Gene	action|compound|START_ENTITY modulates|dobj|action modulates|nsubj|END_ENTITY	Corrigendum : Progesterone_receptor modulates ERa action in breast_cancer .
24064365	0	ERa	20,23	Prolactin	0,9	ERa	Prolactin	13982(Tax:10090)	19109(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Prolactin activates ERa in the absence of ligand in female mammary development and carcinogenesis in vivo .
21217774	0	ERa	40,43	RAC3	0,4	ERa	RAC3	2099	5881	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	RAC3 is a pro-migratory co-activator of ERa .
26224478	0	ERa	66,69	Transforming_growth_factor-b	0,28	ERa	Transforming growth factor-b	26284	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Transforming_growth_factor-b signaling pathway cross-talking with ERa signaling pathway on regulating the growth of uterine_leiomyoma activated by phenolic environmental estrogens in vitro .
26389696	0	ERa	9,12	UBE3C	60,65	ERa	UBE3C	2099	9690	Gene	Gene	Stimulates|nsubj|START_ENTITY Stimulates|dobj|Activity Activity|nmod|END_ENTITY	Liganded ERa Stimulates the E3_Ubiquitin_Ligase Activity of UBE3C to Facilitate Cell Proliferation .
22799738	0	ERa	40,43	estrogen_receptor_alpha	15,38	ERa	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of estrogen_receptor_alpha -LRB- ERa -RRB- gene polymorphisms with endometrial thickness and lipid profile in women with breast_cancer treated with aromatase inhibitors .
26522726	0	ERa	45,48	mTORC1	0,6	ERa	mTORC1	2099	382056(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	mTORC1 directly phosphorylates and activates ERa upon estrogen stimulation .
24601884	0	ERa	141,144	miR-222	115,122	ERa	miR-222	2099	407007	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Differential expression of microRNAs in omental adipose tissue from gestational_diabetes_mellitus subjects reveals miR-222 as a regulator of ERa expression in estrogen-induced insulin resistance .
19383788	0	ERalpha	0,7	CDH-1	43,48	ERalpha	CDH-1	2099	999	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	ERalpha as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast_cancer cells .
20219888	0	ERalpha	15,22	COUP-TFII	35,44	ERalpha	COUP-TFII	13982(Tax:10090)	11819(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization .
20101232	0	ERalpha	0,7	E-cadherin	41,51	ERalpha	E-cadherin	2099	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	ERalpha signaling through slug regulates E-cadherin and EMT .
17911007	0	ERalpha	53,60	ERbeta	72,78	ERalpha	ERbeta	2099	2100	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Prognostic significance of oestrogen receptor alpha -LRB- ERalpha -RRB- and beta -LRB- ERbeta -RRB- , progesterone_receptor_A -LRB- PR-A -RRB- _ and_B -LRB- PR-B -RRB- in endometrial_carcinomas .
20208560	0	ERalpha	37,44	FOXM1	0,5	ERalpha	FOXM1	2099	2305	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	FOXM1 is a transcriptional target of ERalpha and has a critical role in breast_cancer endocrine sensitivity and resistance .
10537130	0	ERalpha	111,118	GnRH	61,65	ERalpha	GnRH	24890(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
12552233	0	ERalpha	31,38	PR	78,80	ERalpha	PR	2099	5241	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	Analysis of estrogen_receptor -LRB- ERalpha and ERbeta -RRB- and progesterone_receptor -LRB- PR -RRB- polymorphisms in uterine leiomyomas .
9867849	0	ERalpha	106,113	SHP	28,31	ERalpha	SHP	24890(Tax:10116)	117274(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta .
12790809	0	ERalpha	49,56	SRC1	92,96	ERalpha	SRC1	2099	10011	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Transcriptional activation by estrogen receptor -LRB- ERalpha -RRB- and steroid_receptor_coactivator -LRB- SRC1 -RRB- involves distinct mechanisms in yeast and mammalian cells .
19936027	0	ERalpha	0,7	TERT	48,52	ERalpha	TERT	2099	7015	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells .
15351732	0	ERalpha	16,23	XBP-1	0,5	ERalpha	XBP-1	2099	7494	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	XBP-1 increases ERalpha transcriptional activity through regulation of large-scale chromatin unfolding .
16249893	0	ERalpha	50,57	estrogen_receptor-alpha	25,48	ERalpha	estrogen receptor-alpha	2099	2099	Gene	Gene	and|appos|START_ENTITY and|compound|END_ENTITY	Cellular localization of estrogen_receptor-alpha -LRB- ERalpha -RRB- and - beta -LRB- ERbeta -RRB- mRNA in the boar testis .
11507039	0	ERalpha	160,167	estrogen_receptor_alpha	102,125	ERalpha	estrogen receptor alpha	2099	2099	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Phosphatidylinositol-3-OH_Kinase -LRB- PI3K -RRB- / AKT2 , activated in breast_cancer , regulates and is induced by estrogen_receptor_alpha -LRB- ERalpha -RRB- via interaction between ERalpha and PI3K .
12627470	0	ERalpha	95,102	estrogen_receptor_alpha	70,93	ERalpha	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in the coding sequence and flanking splice junctions of the estrogen_receptor_alpha -LRB- ERalpha -RRB- gene does not play an important role in genetic susceptibility to bipolar_disorder or bipolar affective puerperal_psychosis .
17092701	0	ERalpha	43,50	estrogen_receptor_alpha	18,41	ERalpha	estrogen receptor alpha	2099	2099	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role of estrogen_receptor_alpha -LRB- ERalpha -RRB- phosphorylated at Serine118 in human breast_cancer in vivo .
17158758	0	ERalpha	82,89	estrogen_receptor_alpha	57,80	ERalpha	estrogen receptor alpha	2099	2099	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Endocrine therapy resistance can be associated with high estrogen_receptor_alpha -LRB- ERalpha -RRB- expression and reduced ERalpha phosphorylation in breast_cancer models .
17960587	0	ERalpha	52,59	estrogen_receptor_alpha	27,50	ERalpha	estrogen receptor alpha	2099	2099	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Differential expression of estrogen_receptor_alpha -LRB- ERalpha -RRB- protein in MCF-7 breast_cancer cells chronically exposed to TCDD .
18814026	0	ERalpha	38,45	estrogen_receptor_alpha	13,36	ERalpha	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Silencing of estrogen_receptor_alpha -LRB- ERalpha -RRB- gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast_cancer .
10537130	0	ERalpha	111,118	gonadotropin-releasing_hormone	29,59	ERalpha	gonadotropin-releasing hormone	24890(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
17312152	0	ERalpha	233,240	histone_deacetylase_2	206,227	ERalpha	histone deacetylase 2	2099	3066	Gene	Gene	dissociating|nmod|START_ENTITY dissociating|dobj|END_ENTITY	17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen_receptor_alpha -LRB- ERalpha -RRB- and augmentation of transcriptional activity of Sp1 by dissociating histone_deacetylase_2 from ERalpha .
19578757	0	ERalpha	50,57	p53	28,31	ERalpha	p53	2099	7157	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions .
19718048	0	ERalpha	35,42	p72	21,24	ERalpha	p72	2099	10521	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The DEAD-box protein p72 regulates ERalpha - / oestrogen-dependent transcription and cell growth , and is associated with improved survival in ERalpha-positive breast_cancer .
21965746	0	ERas	0,4	CPT-11	28,34	ERas	CPT-11	3266	963084(Tax:115711)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	ERas enhances resistance to CPT-11 in gastric_cancer .
20566745	0	ERas	31,35	ES_cell-expressed_Ras	8,29	ERas	ES cell-expressed Ras	3266	3266	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of ES_cell-expressed_Ras -LRB- ERas -RRB- in tumorigenicity of gastric_cancer .
20811723	0	ERas	124,128	embryonic_stem_cell-expressed_Ras	89,122	ERas	embryonic stem cell-expressed Ras	3266	3266	Gene	Gene	signal|appos|START_ENTITY signal|amod|END_ENTITY	Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic_stem_cell-expressed_Ras -LRB- ERas -RRB- signal in neuroblastoma cells .
23860318	0	ERb	131,134	ERa	120,123	ERb	ERa	2100	2099	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERa and/or ERb transactivation .
26899323	0	ERb	17,20	IGF-I	0,5	ERb	IGF-I	2100	3479	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	IGF-I stimulates ERb and aromatase expression via IGF1R/PI3K/AKT-mediated transcriptional activation in endometriosis .
21266854	0	ERb	0,3	IL-8	25,29	ERb	IL-8	2100	3576	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	ERb and PEA3 co-activate IL-8 expression and promote the invasion of breast_cancer cells .
22186418	0	ERb	71,74	estrogen_receptor-b	50,69	ERb	estrogen receptor-b	13983(Tax:10090)	13983(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Anxiolytic effects and neuroanatomical targets of estrogen_receptor-b -LRB- ERb -RRB- activation by a selective ERb agonist in female mice .
26208479	0	ERb	68,71	estrogen_receptor_beta	44,66	ERb	estrogen receptor beta	13983(Tax:10090)	13983(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Intracellular lactate-mediated induction of estrogen_receptor_beta -LRB- ERb -RRB- in biphasic malignant_pleural_mesothelioma cells .
22434086	0	ERb	4,7	oxytocin	75,83	ERb	oxytocin	13983(Tax:10090)	18429(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The ERb ligand 5a-androstane , 3b,17b-diol -LRB- 3b-diol -RRB- regulates hypothalamic oxytocin -LRB- Oxt -RRB- gene expression .
17911007	0	ERbeta	72,78	ERalpha	53,60	ERbeta	ERalpha	2100	2099	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Prognostic significance of oestrogen receptor alpha -LRB- ERalpha -RRB- and beta -LRB- ERbeta -RRB- , progesterone_receptor_A -LRB- PR-A -RRB- _ and_B -LRB- PR-B -RRB- in endometrial_carcinomas .
11061547	0	ERbeta	24,30	Estrogen_receptor	0,17	ERbeta	Estrogen receptor	2100	2099	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Estrogen_receptor beta -LRB- ERbeta -RRB- messenger ribonucleic acid -LRB- mRNA -RRB- expression within the human forebrain : distinct distribution pattern to ERalpha mRNA .
19878085	0	ERbeta	59,65	estrogen_receptor	30,47	ERbeta	estrogen receptor	2100	2099	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	+1730 _ G/A polymorphism of the estrogen_receptor beta gene -LRB- ERbeta -RRB- may be an important genetic factor predisposing to endometriosis .
9348186	0	ERbeta	111,117	estrogen_receptor-beta	87,109	ERbeta	estrogen receptor-beta	13983(Tax:10090)	13983(Tax:10090)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Tissue distribution and quantitative analysis of estrogen_receptor-alpha -LRB- ERalpha -RRB- and estrogen_receptor-beta -LRB- ERbeta -RRB- messenger ribonucleic_acid in the wild-type and ERalpha-knockout mouse .
17709512	0	ERdj3	18,23	BOB-1	34,39	ERdj3	BOB-1	51726	5450	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of ERdj3 and OBF-1 / BOB-1 / OCA-B as direct targets of XBP-1 during plasma cell differentiation .
17709512	0	ERdj3	18,23	OCA-B	40,45	ERdj3	OCA-B	51726	5450	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of ERdj3 and OBF-1 / BOB-1 / OCA-B as direct targets of XBP-1 during plasma cell differentiation .
18400946	0	ERdj4	0,5	surfactant_protein_C	99,119	ERdj4	surfactant protein C	4189	6440	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|degradation degradation|nmod|END_ENTITY	ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant_protein_C .
23641861	0	ERdj5	26,31	DNJ-27	19,25	ERdj5	DNJ-27	54431	173065(Tax:6239)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Protective role of DNJ-27 / ERdj5 in Caenorhabditis_elegans models of human neurodegenerative_diseases .
12761212	0	ERp18	31,36	thioredoxin	74,85	ERp18	thioredoxin	51060	7295	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Functional characterization of ERp18 , a new endoplasmic reticulum-located thioredoxin superfamily member .
16940051	0	ERp27	0,5	ERp57	121,126	ERp27	ERp57	121506	2923	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ERp27 , a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member , interacts with ERp57 .
25130463	0	ERp29	19,24	calreticulin	65,77	ERp29	calreticulin	10961	811	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	PDI family protein ERp29 forms 1:1 complex with lectin chaperone calreticulin .
16677078	0	ERp29	0,5	thioredoxin	47,58	ERp29	thioredoxin	10961	7295	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	ERp29 , an unusual redox-inactive member of the thioredoxin family .
20074551	0	ERp46	0,5	AdipoR1	15,22	ERp46	AdipoR1	81567	51094	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	ERp46 binds to AdipoR1 , but not AdipoR2 , and modulates adiponectin signalling .
22215138	0	ERp5	14,18	MICA	109,113	ERp5	MICA	10130	100507436	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|association association|nmod|END_ENTITY	Expression of ERp5 and GRP78 on the membrane of chronic_lymphocytic_leukemia cells : association with soluble MICA shedding .
16940051	0	ERp57	121,126	ERp27	0,5	ERp57	ERp27	2923	121506	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ERp27 , a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member , interacts with ERp57 .
24815697	0	ERp57	0,5	MCU	57,60	ERp57	MCU	2923	90550	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	ERp57 modulates mitochondrial calcium uptake through the MCU .
19995546	0	ERp57	8,13	STAT3	63,68	ERp57	STAT3	2923	6774	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line .
20022947	0	ERp57	0,5	STAT3	16,21	ERp57	STAT3	14827(Tax:10090)	20848(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	ERp57 modulates STAT3 signaling from the lumen of the endoplasmic reticulum .
25605256	0	ERp57	0,5	STAT3	16,21	ERp57	STAT3	2923	6774	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nummod|END_ENTITY	ERp57 modulates STAT3 activity in radioresistant laryngeal_cancer cells and serves as a prognostic marker for laryngeal_cancer .
12060494	0	ERp57	71,76	Stat3	83,88	ERp57	Stat3	2923	6774	Gene	Gene	protein|appos|START_ENTITY glucose-regulated|dobj|protein glucose-regulated|nmod|END_ENTITY	Association of the chaperone glucose-regulated protein 58 -LRB- GRP58/ER -60 / ERp57 -RRB- with Stat3 in cytosol and plasma membrane complexes .
15845382	0	ERp57	0,5	protein_disulfide_isomerase	29,56	ERp57	protein disulfide isomerase	281803(Tax:9913)	281373(Tax:9913)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	ERp57 binds competitively to protein_disulfide_isomerase and calreticulin .
16740484	0	ERp57	114,119	protein_disulfide_isomerase	25,52	ERp57	protein disulfide isomerase	2923	64714	Gene	Gene	participation|nmod|START_ENTITY evidence|nmod|participation role|dep|evidence role|nmod|activity activity|compound|END_ENTITY	A role for sperm surface protein_disulfide_isomerase activity in gamete fusion : evidence for the participation of ERp57 .
8687406	0	ERp60	0,5	protein_disulphide_isomerase	30,58	ERp60	protein disulphide isomerase	171423	5034	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	ERp60 does not substitute for protein_disulphide_isomerase as the beta-subunit of prolyl 4-hydroxylase .
8477750	0	ERp72	26,31	CaBP2	0,5	ERp72	CaBP2	116598(Tax:10116)	499298(Tax:10116)	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity .
1815957	0	ES-1	40,44	esterase-1	28,38	ES-1	esterase-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Determination of rat plasma esterase-1 -LRB- ES-1 -RRB- activity by scanning densitometry of gradient polyacrylamide gels with zymogram detection .
2093139	0	ES-1	67,71	esterase-1	55,65	ES-1	esterase-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Influence of dietary fats on butyrylcholinesterase and esterase-1 -LRB- ES-1 -RRB- activity in plasma of rats .
2396444	0	ES-1	60,64	esterase-1	48,58	ES-1	esterase-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Specific effect of the amount of dietary fat on esterase-1 -LRB- ES-1 -RRB- activity of rat plasma .
2747435	0	ES-1	19,23	esterase-1	7,17	ES-1	esterase-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Plasma esterase-1 -LRB- ES-1 -RRB- activity is increased in rats fed high-fat diets .
1883319	0	ES-28	41,46	esterase_28	28,39	ES-28	esterase 28	109612(Tax:10090)	109612(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Genetic characterization of esterase_28 -LRB- ES-28 -RRB- of the house_mouse .
15383320	0	ESAM	30,34	MAGI-1	77,83	ESAM	MAGI-1	90952	9223	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts .
26830052	0	ESBL	58,62	blaCTX-M-15	0,11	ESBL	blaCTX-M-15	13906541	9538104	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	blaCTX-M-15 carried by IncF-type plasmids is the dominant ESBL gene in Escherichia_coli and Klebsiella_pneumoniae at a hospital in Ghana .
15821733	0	ESCO2	43,48	ECO1	75,79	ESCO2	ECO1	157570	850584(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Roberts_syndrome is caused by mutations in ESCO2 , a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion .
19074849	0	ESE-1	0,5	EGR-1	6,11	ESE-1	EGR-1	1999	1958	Gene	Gene	START_ENTITY|appos|plays plays|nsubj|END_ENTITY	ESE-1 / EGR-1 pathway plays a role in tolfenamic_acid-induced apoptosis in colorectal_cancer cells .
12414801	0	ESE-1	0,5	MIP-3alpha	66,76	ESE-1	MIP-3alpha	1999	6364	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	ESE-1 , an enterocyte-specific Ets transcription factor , regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells .
24971534	0	ESE-1	67,72	OCT4	30,34	ESE-1	OCT4	1999	5460	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of OCT4 by the ETS transcription factor ESE-1 in NCCIT human embryonic_carcinoma cells .
10891534	0	ESE-1	84,89	ets_gene-1	72,82	ESE-1	ets gene-1	1999	1999	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis and mutational screening of the epithelium-specific ets_gene-1 -LRB- ESE-1 -RRB- in patients with squamous anal_cancer .
15075319	0	ESE-1	83,88	p300	114,118	ESE-1	p300	1999	2033	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300 , CREB-binding_protein , and Ku_70 / 86 .
10556428	0	ESL-1	45,50	E-selectin_ligand_1	24,43	ESL-1	E-selectin ligand 1	20340(Tax:10090)	20340(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure of the murine E-selectin_ligand_1 -LRB- ESL-1 -RRB- gene and assignment to Chromosome 8 .
26906498	0	ESM-1	48,53	endothelial_cell-specific_molecule-1	10,46	ESM-1	Endothelial cell-specific molecule-1	11082	11082	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of endothelial_cell-specific_molecule-1 -LRB- ESM-1 -RRB- in overt hypothyroidisim .
20383661	0	ESM-1	56,61	endothelial_cell_specific_molecule-1	18,54	ESM-1	endothelial cell specific molecule-1	11082	11082	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of endothelial_cell_specific_molecule-1 -LRB- ESM-1 -RRB- in gastric_cancer .
11192427	0	ESR	41,44	estrogen_receptor	23,40	ESR	estrogen receptor	100737874	100737874	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- The genetic effect of estrogen_receptor -LRB- ESR -RRB- on litter size traits in pig -RSB- .
14617832	0	ESR	71,74	estrogen_receptor	47,64	ESR	estrogen receptor	100737874	100737874	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relation between Ava I polymorphism within the estrogen_receptor gene -LRB- ESR -RRB- and meatiness in Polish Large White boars .
22792352	0	ESR1	42,46	AR	77,79	ESR1	AR	2099	367	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	Microsatellites in the estrogen_receptor -LRB- ESR1 , ESR2 -RRB- and androgen_receptor -LRB- AR -RRB- genes and breast_cancer risk in African American and Nigerian women .
26069273	0	ESR1	18,22	ERK1/2	46,52	ESR1	ERK1/2	2099	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Estrogen receptor ESR1 mediates activation of ERK1/2 , CREB , and ELK1 in the corpus_of_the_epididymis .
17446729	0	ESR1	26,30	Estrogen_Receptor_1	0,19	ESR1	Estrogen Receptor 1	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Estrogen_Receptor_1 gene -LRB- ESR1 -RRB- variants in Alzheimer 's _ disease .
25979954	0	ESR1	57,61	Estrogen_Receptor_1	36,55	ESR1	Estrogen Receptor 1	2099	2099	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Noninvasive Detection of Activating Estrogen_Receptor_1 -LRB- ESR1 -RRB- Mutations in Estrogen Receptor-Positive Metastatic Breast_Cancer .
20375995	0	ESR1	26,30	Estrogen_receptor_1	0,19	ESR1	Estrogen receptor 1	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Estrogen_receptor_1 gene -LRB- ESR1 -RRB- is associated with restrictive_anorexia_nervosa .
23116284	0	ESR1	26,30	Estrogen_receptor_a	0,19	ESR1	Estrogen receptor a	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Estrogen_receptor_a gene -LRB- ESR1 -RRB- polymorphisms associated with idiopathic premature_ovarian_failure in Chinese women .
22174013	0	ESR1	95,99	NR2E3	56,61	ESR1	NR2E3	2099	10002	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast_cancer .
26528103	0	ESR1	51,55	UGT2B17	57,64	ESR1	UGT2B17	2099	7367	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Polymorphisms of estrogen metabolism-related genes ESR1 , UGT2B17 , and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women .
19936541	0	ESR1	35,39	estrogen_receptor-alpha	10,33	ESR1	estrogen receptor-alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effect of estrogen_receptor-alpha -LRB- ESR1 -RRB- gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy .
20080637	0	ESR1	58,62	estrogen_receptor-alpha	33,56	ESR1	estrogen receptor-alpha	2099	2099	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MYCN-regulated microRNAs repress estrogen_receptor-alpha -LRB- ESR1 -RRB- expression and neuronal differentiation in human neuroblastoma .
22913342	0	ESR1	67,71	estrogen_receptor-alpha	42,65	ESR1	estrogen receptor-alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cohesin is required for expression of the estrogen_receptor-alpha -LRB- ESR1 -RRB- gene .
25981900	0	ESR1	31,35	estrogen_receptor_1	10,29	ESR1	estrogen receptor 1	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Status of estrogen_receptor_1 -LRB- ESR1 -RRB- gene in mastopathy predicts subsequent development of breast_cancer .
25981900	0	ESR1	31,35	estrogen_receptor_1	10,29	ESR1	estrogen receptor 1	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Status of estrogen_receptor_1 -LRB- ESR1 -RRB- gene in mastopathy predicts subsequent development of breast_cancer .
24282178	0	ESR1	51,55	estrogen_receptor_I	25,44	ESR1	estrogen receptor I	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of the estrogen_receptor_I gene -LRB- ESR1 -RRB- in anorexia_nervosa_and_eating_disorders : no replication found .
21837769	0	ESR1	62,66	estrogen_receptor_a	41,60	ESR1	estrogen receptor a	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A cis-acting regulatory variation of the estrogen_receptor_a -LRB- ESR1 -RRB- gene is associated with hepatitis_B_virus-related liver cirrhosis .
17599809	0	ESR1	81,85	estrogen_receptor_alpha	91,114	ESR1	estrogen receptor alpha	2099	2099	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Risk for premenstrual_dysphoric_disorder is associated with genetic variation in ESR1 , the estrogen_receptor_alpha gene .
18360040	0	ESR1	63,67	estrogen_receptor_alpha	38,61	ESR1	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotype-based case-control study of estrogen_receptor_alpha -LRB- ESR1 -RRB- gene and pregnancy-induced hypertension .
18449864	0	ESR1	55,59	estrogen_receptor_alpha	25,48	ESR1	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association study of the estrogen_receptor_alpha gene -LRB- ESR1 -RRB- and childhood-onset mood_disorders .
19586561	0	ESR1	46,50	estrogen_receptor_alpha	21,44	ESR1	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of the estrogen_receptor_alpha -LRB- ESR1 -RRB- gene and the risk of Alzheimer 's _ disease in a southern Chinese community .
20715834	0	ESR1	110,114	estrogen_receptor_alpha	80,103	ESR1	estrogen receptor alpha	407238(Tax:9913)	407238(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen_receptor_alpha gene -LRB- ESR1 -RRB- .
20884142	0	ESR1	80,84	estrogen_receptor_alpha	50,73	ESR1	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evaluation of PvuII and XbaI polymorphisms in the estrogen_receptor_alpha gene -LRB- ESR1 -RRB- in relation to menstrual cycle timing and reproductive parameters in post-menopausal women .
24756215	0	ESR1	36,40	estrogen_receptor_alpha	11,34	ESR1	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Absence of estrogen_receptor_alpha -LRB- ESR1 -RRB- gene amplification in a series of breast_cancers in Taiwan .
21080949	0	ESR2	56,60	Estrogen_Receptor_Beta	32,54	ESR2	Estrogen Receptor Beta	2100	2100	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Common genetic variation in the Estrogen_Receptor_Beta -LRB- ESR2 -RRB- gene and osteoarthritis : results of a meta-analysis .
26147849	0	ESR2	34,38	Estrogen_Receptor_ERb	11,32	ESR2	Estrogen Receptor ERb	25149(Tax:10116)	25149(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Changes in Estrogen_Receptor_ERb -LRB- ESR2 -RRB- Expression without Changes in the Estradiol Levels in the Prostate of Aging Rats .
18704709	0	ESR2	53,57	estrogen_receptor	29,46	ESR2	estrogen receptor	2100	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic polymorphisms in the estrogen_receptor beta -LRB- ESR2 -RRB- gene and the risk of epithelial_ovarian_carcinoma .
15894829	0	ESR2	87,91	estrogen_receptor_beta	63,85	ESR2	estrogen receptor beta	2100	13983(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association study using single nucleotide polymorphisms in the estrogen_receptor_beta -LRB- ESR2 -RRB- gene for preeclampsia .
22673910	0	ESRP1	37,42	CD44	24,28	ESRP1	CD44	207920(Tax:10090)	12505(Tax:10090)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell .
26380406	0	ESRRB	65,70	estrogen_related_receptor_b	31,58	ESRRB	estrogen related receptor b	100151940(Tax:9823)	100151940(Tax:9823)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	-LSB- Cloning and regulation of pig estrogen_related_receptor_b gene -LRB- ESRRB -RRB- promoter -RSB- .
25023176	0	ESRRB	40,45	estrogen_related_receptor_beta	8,38	ESRRB	estrogen related receptor beta	2103	2103	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of estrogen_related_receptor_beta -LRB- ESRRB -RRB- in DFN35B hearing_impairment and dental_decay .
23589079	0	ESRRG	68,73	miR-205	0,7	ESRRG	miR-205	2104	406988	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial_carcinoma .
11121195	0	ESR_1	128,133	estrogen_receptor_alpha	98,121	ESR 1	estrogen receptor alpha	2099	2099	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular genetic studies of bipolar_disorder and puerperal_psychosis at two polymorphisms in the estrogen_receptor_alpha gene -LRB- ESR_1 -RRB- .
15522178	0	EST	42,45	estrogen_sulfotransferase	15,40	EST	estrogen sulfotransferase	6783	6783	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Expression of estrogen_sulfotransferase -LRB- EST -RRB- gene and bridging_integrator_protein-1 -LRB- BIN1 -RRB- gene and their significance in breast tissues -RSB- .
10049594	0	ESX	46,49	ELF3	34,38	ESX	ELF3	1999	1999	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the human ELF3 -LRB- ESE-1 / ESX -RRB- gene , a member of the Ets transcription factor family , and identification of a functional promoter .
12032832	0	ESX	20,23	ErbB2	0,5	ESX	ErbB2	1999	2064	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|amod|END_ENTITY	ErbB2 activation of ESX gene expression .
15899157	0	ESX1	86,90	extra-embryonic_tissue-spermatogenesis-homeobox_gene_1	30,84	ESX1	extra-embryonic tissue-spermatogenesis-homeobox gene 1	13984(Tax:10090)	13984(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Stage-dependent expression of extra-embryonic_tissue-spermatogenesis-homeobox_gene_1 -LRB- ESX1 -RRB- protein , a candidate marker for X chromosome-bearing sperm .
20566745	0	ES_cell-expressed_Ras	8,29	ERas	31,35	ES cell-expressed Ras	ERas	3266	3266	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of ES_cell-expressed_Ras -LRB- ERas -RRB- in tumorigenicity of gastric_cancer .
9176139	0	ET-1	0,4	EGF	21,24	ET-1	EGF	100726197	100714471	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	ET-1 cooperates with EGF to induce mitogenesis via a PTX-sensitive pathway in airway_smooth_muscle_cells .
12055094	0	ET-1	0,4	ERK	16,19	ET-1	ERK	13614(Tax:10090)	26413(Tax:10090)	Gene	Gene	stimulates|compound|START_ENTITY END_ENTITY|nsubj|stimulates	ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells .
14644778	0	ET-1	87,91	ERK	69,72	ET-1	ERK	24323(Tax:10116)	24338(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Contribution of PKC-dependent and - independent processes in temporal ERK regulation by ET-1 , PDGF , and EGF in rat myometrial cells .
18823320	0	ET-1	18,22	ETA	23,26	ET-1	ETA	24323(Tax:10116)	24326(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|contributes contributes|nsubj|END_ENTITY	Activation of the ET-1 / ETA pathway contributes to erectile_dysfunction associated with mineralocorticoid hypertension .
9252556	0	ET-1	19,23	IL-1_beta	0,9	ET-1	IL-1 beta	24323(Tax:10116)	24494(Tax:10116)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-1_beta inhibits ET-1 production by ATII cells in vitro : evidence for involvement of cyclooxygenase_2 pathway .
16161448	0	ET-1	51,55	IL-6	39,43	ET-1	IL-6	24323(Tax:10116)	24498(Tax:10116)	Gene	Gene	liquid|amod|START_ENTITY liquid|nmod|END_ENTITY	-LSB- Influence of Minkeqing oral liquid on IL-6 , IL-8 , ET-1 , TX-B2 in blood and to observe bronchoalveolar lavage fluid of the rat with inhalating ovalbumin -RSB- .
8897812	0	ET-1	0,4	IL-6	13,17	ET-1	IL-6	1906	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	ET-1 induces IL-6 gene expression in human umbilical vein endothelial cells : synergistic effect of IL-1 .
11972170	0	ET-1	1,5	c-fos	44,49	ET-1	c-fos	24323(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	-LSB- ET-1 induces the expression of prooncogene c-fos in cultured neonatal rat myocardial cells -RSB- .
10190051	0	ET-1	58,62	endothelin-1	44,56	ET-1	endothelin-1	100726197	100726197	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Antigen-induced elevation of immunoreactive endothelin-1 -LRB- ET-1 -RRB- levels in ovalbumin-sensitized guinea_pig airway tissue .
11210078	0	ET-1	101,105	endothelin-1	87,99	ET-1	endothelin-1	1906	1906	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interactions of lymphotoxin alpha -LRB- TNF-beta -RRB- , angiotensin-converting_enzyme -LRB- ACE -RRB- , and endothelin-1 -LRB- ET-1 -RRB- gene polymorphisms in adult_periodontitis .
12674218	0	ET-1	46,50	endothelin-1	32,44	ET-1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Negative chronotropic effect of endothelin-1 -LRB- ET-1 -RRB- in the cardiac pacemaker tissue .
14575417	0	ET-1	43,47	endothelin-1	29,41	ET-1	endothelin-1	1906	1906	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of endothelin-1 -LRB- ET-1 -RRB- in human acute renal allograft rejection .
1964364	0	ET-1	65,69	endothelin-1	51,63	ET-1	endothelin-1	1906	1906	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Contractile effects and receptor distributions for endothelin-1 -LRB- ET-1 -RRB- in human and animal airways .
9222086	0	ET-1	25,29	endothelin-1	11,23	ET-1	endothelin-1	1906	1906	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of endothelin-1 -LRB- ET-1 -RRB- on ocular hemodynamics .
25403488	0	ET-1	16,20	miR-648	0,7	ET-1	miR-648	1906	693233	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-648 targets ET-1 mRNA and is co-transcriptionally regulated with MICAL3 by PAX5 .
1701397	0	ET-2	43,47	endothelin-2	29,41	ET-2	endothelin-2	1907	1907	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Specific expression of human endothelin-2 -LRB- ET-2 -RRB- gene in a renal_adenocarcinoma cell line .
1725387	0	ET-2	28,32	endothelin-2	14,26	ET-2	endothelin-2	1907	1907	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of endothelin-2 -LRB- ET-2 -RRB- gene in a human renal_adenocarcinoma cell line : purification and cDNA cloning of ET-2 .
8717152	0	ET-2	28,32	endothelin-2	14,26	ET-2	endothelin-2	1907	1907	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of endothelin-2 -LRB- ET-2 -RRB- on migration and changes in cytosolic free calcium of neutrophils .
22897442	0	ET-3	53,57	EDNRB	58,63	ET-3	EDNRB	13616(Tax:10090)	13618(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Apolipoprotein_B is a new target of the GDNF/RET and ET-3 / EDNRB signalling pathways .
7968263	0	ET-B	39,43	endothelin_receptor_subtype_B	8,37	ET-B	endothelin receptor subtype B	50672(Tax:10116)	50672(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of endothelin_receptor_subtype_B -LRB- ET-B -RRB- in myocardial_ischemia .
18823320	0	ETA	23,26	ET-1	18,22	ETA	ET-1	24326(Tax:10116)	24323(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY Activation|parataxis|contributes Activation|nmod|END_ENTITY	Activation of the ET-1 / ETA pathway contributes to erectile_dysfunction associated with mineralocorticoid hypertension .
15475516	0	ETA	69,72	ETB	106,109	ETA	ETB	1909	1910	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|acl|dephosphorylation dephosphorylation|nmod|END_ENTITY	Gq/G13 signaling by ET-1 in smooth muscle : MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB .
25992919	0	ETA	85,88	ETB	150,153	ETA	ETB	24326(Tax:10116)	50672(Tax:10116)	Gene	Gene	Receptors|compound|START_ENTITY Selectivity|nmod|Receptors Depends|nmod|Selectivity Effects|nmod|Depends Effects|nmod|Receptors Receptors|compound|END_ENTITY	Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors .
25992919	0	ETA	85,88	ETB	96,99	ETA	ETB	24326(Tax:10116)	50672(Tax:10116)	Gene	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors .
7730018	0	ETA	34,37	ETB	57,60	ETA	ETB	281749(Tax:9913)	281750(Tax:9913)	Gene	Gene	endothelin_A|appos|START_ENTITY endothelin_A|appos|END_ENTITY	Characterization of endothelin_A -LRB- ETA -RRB- and endothelin B -LRB- ETB -RRB- receptors in cultured bovine retinal pericytes .
9105715	0	ETA	25,28	ETB	80,83	ETA	ETB	24326(Tax:10116)	50672(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY Activation|nmod|receptors masks|nsubj|Activation masks|ccomp|isolated isolated|nsubj|role role|nmod|receptors receptors|compound|END_ENTITY	Activation of endothelin ETA receptors masks the constrictor role of endothelin ETB receptors in rat isolated small mesenteric arteries .
20371740	0	ETA	28,31	Endothelin_type_A_receptor	0,26	ETA	Endothelin type A receptor	1909	1909	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Endothelin_type_A_receptor -LRB- ETA -RRB- expression is regulated by HOXA10 in human endometrial stromal cells .
15475516	0	ETA	69,72	MYPT1	43,48	ETA	MYPT1	1909	4659	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Gq/G13 signaling by ET-1 in smooth muscle : MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB .
8019752	0	ETA	0,3	endothelin-1	56,68	ETA	endothelin-1	24326(Tax:10116)	24323(Tax:10116)	Gene	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|nmod|END_ENTITY	ETA receptor-mediated responses to endothelin-1 and big endothelin-1 in the rat kidney .
9184171	0	ETA	59,62	scFv	48,52	ETA	scFv	1909	652070	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Construction and functional characterization of scFv -LRB- 14E1 -RRB- - ETA - a novel , highly potent antibody-toxin specific for the EGF_receptor .
24265756	0	ETB	64,67	AP-1	15,19	ETB	AP-1	1910	3725	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of AP-1 and C/EBPb in upregulation of endothelin B -LRB- ETB -RRB- receptor expression in a rodent model of glaucoma .
15475516	0	ETB	106,109	ETA	69,72	ETB	ETA	1910	1909	Gene	Gene	dephosphorylation|nmod|START_ENTITY phosphorylation|acl|dephosphorylation phosphorylation|nmod|END_ENTITY	Gq/G13 signaling by ET-1 in smooth muscle : MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB .
25992919	0	ETB	150,153	ETA	85,88	ETB	ETA	50672(Tax:10116)	24326(Tax:10116)	Gene	Gene	Receptors|compound|START_ENTITY Effects|nmod|Receptors Effects|nmod|Depends Depends|nmod|Selectivity Selectivity|nmod|Receptors Receptors|compound|END_ENTITY	Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors .
25992919	0	ETB	96,99	ETA	85,88	ETB	ETA	50672(Tax:10116)	24326(Tax:10116)	Gene	Gene	Receptors|compound|START_ENTITY Receptors|compound|END_ENTITY	Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors .
7730018	0	ETB	57,60	ETA	34,37	ETB	ETA	281750(Tax:9913)	281749(Tax:9913)	Gene	Gene	endothelin_A|appos|START_ENTITY endothelin_A|appos|END_ENTITY	Characterization of endothelin_A -LRB- ETA -RRB- and endothelin B -LRB- ETB -RRB- receptors in cultured bovine retinal pericytes .
9105715	0	ETB	80,83	ETA	25,28	ETB	ETA	50672(Tax:10116)	24326(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY role|nmod|receptors isolated|nsubj|role masks|ccomp|isolated masks|nsubj|Activation Activation|nmod|receptors receptors|compound|END_ENTITY	Activation of endothelin ETA receptors masks the constrictor role of endothelin ETB receptors in rat isolated small mesenteric arteries .
25992919	0	ETB	150,153	ETB	96,99	ETB	ETB	50672(Tax:10116)	50672(Tax:10116)	Gene	Gene	Receptors|compound|START_ENTITY Effects|nmod|Receptors Effects|nmod|Depends Depends|nmod|Selectivity Selectivity|nmod|Receptors Receptors|compound|END_ENTITY	Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors .
25992919	0	ETB	96,99	ETB	150,153	ETB	ETB	50672(Tax:10116)	50672(Tax:10116)	Gene	Gene	Receptors|compound|START_ENTITY Selectivity|nmod|Receptors Depends|nmod|Selectivity Effects|nmod|Depends Effects|nmod|Receptors Receptors|compound|END_ENTITY	Vascular Effects of Endothelin Receptor Antagonists Depends on Their Selectivity for ETA Versus ETB Receptors and on the Functionality of Endothelial ETB Receptors .
26232046	0	ETB	0,3	MMP-9	22,27	ETB	MMP-9	50672(Tax:10116)	81687(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status_epilepticus .
8843705	0	ETB	36,39	NHE3	63,67	ETB	NHE3	1910	6550	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Role of tyrosine kinase pathways in ETB receptor activation of NHE3 .
24929581	0	ETEC	113,117	PR-39	52,57	ETEC	PR-39	106455643	407610(Tax:9823)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of porcine antimicrobial peptide PR-39 and its induction by enterotoxigenic Escherichia coli -LRB- ETEC -RRB- F4ac .
8812452	0	ETF	104,107	embryonic_TEA_domain-containing_factor	64,102	ETF	embryonic TEA domain-containing factor	21677(Tax:10090)	21677(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structural organization and chromosomal assignment of the mouse embryonic_TEA_domain-containing_factor -LRB- ETF -RRB- gene .
26349199	0	ETFDH	72,77	ELECTRON_TRANSFERRING_FLAVOPROTEIN_DEHYDROGENASE	22,70	ETFDH	ELECTRON TRANSFERRING FLAVOPROTEIN DEHYDROGENASE	2110	2110	Gene	Gene	GENE|appos|START_ENTITY GENE|compound|END_ENTITY	NOVEL MUTATION OF THE ELECTRON_TRANSFERRING_FLAVOPROTEIN_DEHYDROGENASE -LRB- ETFDH -RRB- GENE IN THE ISOLATED MYOPATHIC FORM OF COENZYME q10 DEFICIENCY .
17412732	0	ETFDH	126,131	electron-transferring-flavoprotein_dehydrogenase	76,124	ETFDH	electron-transferring-flavoprotein dehydrogenase	2110	2110	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The myopathic form of coenzyme_Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein_dehydrogenase -LRB- ETFDH -RRB- gene .
21117868	0	ETHYLENE_INSENSITIVE2	65,86	AtMYB44	21,28	ETHYLENE INSENSITIVE2	AtMYB44	831889(Tax:3702)	836865(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor AtMYB44 regulates induced expression of the ETHYLENE_INSENSITIVE2 gene in Arabidopsis responding to a harpin protein .
25615281	0	ETNK1	52,57	ethanolamine_kinase_1	29,50	ETNK1	ethanolamine kinase 1	55500	55500	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel recurrent mutations in ethanolamine_kinase_1 -LRB- ETNK1 -RRB- gene in systemic mastocytosis with eosinophilia and chronic_myelomonocytic_leukemia .
11090081	0	ETO	6,9	AML-1	0,5	ETO	AML-1	862	861	Gene	Gene	protein|compound|START_ENTITY inhibitor|nsubj|protein END_ENTITY|appos|inhibitor	AML-1 / ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic_leukemia zinc finger protein .
17493351	0	ETO	64,67	AML-1	58,63	ETO	AML-1	862	861	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Immunophenotypic features of acute_myeloid_leukemia with AML-1 / ETO fusion gene -RSB- .
19175988	11	ETO	1301,1304	AML1	1295,1299	ETO	AML1	862	861	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	CONCLUSIONS : The synthesized siRNAs can inhibit AML1 - ETO fusion gene expression .
15231665	0	ETO-2	19,24	MTG16	26,31	ETO-2	MTG16	863	863	Gene	Gene	interactions|amod|START_ENTITY interactions|appos|END_ENTITY	AML1-ETO decreases ETO-2 -LRB- MTG16 -RRB- interactions with nuclear_receptor_corepressor , an effect that impairs granulocyte differentiation .
24857950	0	ETS-1	15,20	FBI-1	0,5	ETS-1	FBI-1	2113	51341	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal_carcinoma cells .
26020937	0	ETS-1	27,32	FBI-1	12,17	ETS-1	FBI-1	2113	51341	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Correction : FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal_Carcinoma Cells .
21732343	0	ETS-1	0,5	RhoC	6,10	ETS-1	RhoC	2113	389	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	ETS-1 / RhoC signaling regulates the transcription factor c-Jun in melanoma .
11909962	0	ETS-1	21,26	Sp100	0,5	ETS-1	Sp100	2113	6672	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sp100 interacts with ETS-1 and stimulates its transcriptional activity .
11399944	0	ETS-1	14,19	urokinase-type_plasminogen_activator	39,75	ETS-1	urokinase-type plasminogen activator	2113	5328	Gene	Gene	Expression|nmod|START_ENTITY correlated|nsubjpass|Expression correlated|nmod|prognosis prognosis|amod|END_ENTITY	Expression of ETS-1 is correlated with urokinase-type_plasminogen_activator and poor prognosis in pulmonary_adenocarcinoma .
22922762	0	ETS-2	36,41	ERG	0,3	ETS-2	ERG	2114	2078	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	ERG is specifically associated with ETS-2 and ETV-4 , but not with ETS-1 , in prostate_cancer .
23686669	0	ETS-related_gene	29,45	ERG	24,27	ETS-related gene	ERG	2078	2078	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Prognostic potential of ERG -LRB- ETS-related_gene -RRB- expression in prostatic_adenocarcinoma .
15750627	0	ETS-related_gene-1	27,45	ERG1	47,51	ETS-related gene-1	ERG1	3757	3757	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Frequent overexpression of ETS-related_gene-1 -LRB- ERG1 -RRB- in prostate_cancer transcriptome .
19789348	0	ETS-related_protein_81	102,124	ETS_variant_1	88,101	ETS-related protein 81	ETS variant 1	2115	2115	Gene	Gene	Induction|parataxis|START_ENTITY Induction|nmod|END_ENTITY	Induction of prostatic_intraepithelial_neoplasia and modulation of androgen_receptor by ETS_variant_1 / ETS-related_protein_81 .
19789348	0	ETS-related_protein_81	102,124	androgen_receptor	67,84	ETS-related protein 81	androgen receptor	2115	367	Gene	Gene	Induction|parataxis|START_ENTITY Induction|nmod|END_ENTITY	Induction of prostatic_intraepithelial_neoplasia and modulation of androgen_receptor by ETS_variant_1 / ETS-related_protein_81 .
22914732	0	ETS1	0,4	ATXN2	33,38	ETS1	ATXN2	23871(Tax:10090)	20239(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	ETS1 regulates the expression of ATXN2 .
16103071	0	ETS1	37,41	Caspase-1	0,9	ETS1	Caspase-1	23871(Tax:10090)	12362(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis .
12743594	0	ETS1	21,25	EAPII	0,5	ETS1	EAPII	2113	51567	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	EAPII interacts with ETS1 and modulates its transcriptional function .
2187191	0	ETS1	115,119	ETS1	31,35	ETS1	ETS1	2113	2113	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation : regulatory role for the protooncogene ETS1 .
2187191	0	ETS1	31,35	ETS1	115,119	ETS1	ETS1	2113	2113	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation : regulatory role for the protooncogene ETS1 .
8510925	0	ETS1	40,44	GATA-1	19,25	ETS1	GATA-1	396235(Tax:9031)	396450(Tax:9031)	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Transactivation of GATA-1 promoter with ETS1 , ETS2 and ERGB/Hu-FLI -1 proteins : stabilization of the ETS1 protein binding on GATA-1 promoter sequences by monoclonal antibody .
7876544	0	ETS1	8,12	IL-2	16,20	ETS1	IL-2	2113	3558	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of ETS1 in IL-2 gene expression .
25912876	0	ETS1	93,97	MicroRNA-129-5p	0,15	ETS1	MicroRNA-129-5p	2113	100302178	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-129-5p inhibits hepatocellular_carcinoma cell metastasis and invasion via targeting ETS1 .
15247905	0	ETS1	27,31	SP100	0,5	ETS1	SP100	2113	6672	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion .
22516263	0	ETS1	89,93	TCRa	113,117	ETS1	TCRa	2113	28755	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRa gene expression .
8649821	0	ETS1	0,4	p53	17,20	ETS1	p53	2113	7157	Gene	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	ETS1 and ETS2 in p53 regulation : spatial separation of ETS binding sites -LRB- EBS -RRB- modulate protein : DNA interaction .
18322277	0	ETS2	169,173	interferon-tau	94,108	ETS2	interferon-tau	281148(Tax:9913)	317698(Tax:9913)	Gene	Gene	regulating|nmod|START_ENTITY regulating|dobj|activation activation|amod|END_ENTITY	The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2 .
22508727	0	ETS2	27,31	p53	7,10	ETS2	p53	2114	7157	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Mutant p53 cooperates with ETS2 to promote etoposide resistance .
26871468	0	ETS2	20,24	p53	7,10	ETS2	p53	2114	7157	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation .
20400516	0	ETS_protein_TEL	19,34	ETV6	36,40	ETS protein TEL	ETV6	2120	2120	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	DNA binding by the ETS_protein_TEL -LRB- ETV6 -RRB- is regulated by autoinhibition and self-association .
19789348	0	ETS_variant_1	88,101	ETS-related_protein_81	102,124	ETS variant 1	ETS-related protein 81	2115	2115	Gene	Gene	Induction|nmod|START_ENTITY Induction|parataxis|END_ENTITY	Induction of prostatic_intraepithelial_neoplasia and modulation of androgen_receptor by ETS_variant_1 / ETS-related_protein_81 .
19789348	0	ETS_variant_1	88,101	androgen_receptor	67,84	ETS variant 1	androgen receptor	2115	367	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of prostatic_intraepithelial_neoplasia and modulation of androgen_receptor by ETS_variant_1 / ETS-related_protein_81 .
25777458	0	ETV1	32,36	COP1	0,4	ETV1	COP1	2115	64326	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	COP1 , the negative regulator of ETV1 , influences prognosis in triple-negative_breast_cancer .
25884720	0	ETV1	32,36	COP1	0,4	ETV1	COP1	2115	64326	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	COP1 , the negative regulator of ETV1 , influences prognosis in triple-negative_breast_cancer .
26731476	0	ETV1	86,90	JMJD2A	20,26	ETV1	JMJD2A	2115	9682	Gene	Gene	drives|nmod|START_ENTITY drives|nsubj|END_ENTITY	Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1 .
23977394	0	ETV1	36,40	KCTD10	49,55	ETV1	KCTD10	2115	83892	Gene	Gene	analysis|nmod|START_ENTITY reveals|nsubj|analysis reveals|dobj|END_ENTITY	Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal_stromal_tumor .
24762086	0	ETV2	21,25	Sox7	0,4	ETV2	Sox7	2116	83595	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Sox7 is regulated by ETV2 during cardiovascular development .
26452058	0	ETV4	63,67	ACLY	0,4	ETV4	ACLY	2118	47	Gene	Gene	Regulate|nmod|START_ENTITY Regulate|nsubj|END_ENTITY	ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via a-ketoglutarate .
21373373	0	ETV4	13,17	PC3	115,118	ETV4	PC3	2118	5122	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|cells cells|compound|END_ENTITY	The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells .
18172298	0	ETV5	28,32	TMPRSS2	20,27	ETV5	TMPRSS2	2119	7113	Gene	Gene	Characterization|dep|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of TMPRSS2 : ETV5 and SLC45A3 : ETV5 gene fusions in prostate_cancer .
18032421	0	ETV5	11,15	ets_variant_gene_5	17,35	ETV5	ets variant gene 5	104156(Tax:10090)	104156(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of ETV5 -LRB- ets_variant_gene_5 -RRB- on testis and body growth , time course of spermatogonial stem cell loss , and fertility in mice .
22968857	0	ETV5	0,4	matrix_metalloproteinase_2	23,49	ETV5	matrix metalloproteinase 2	2119	4313	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	ETV5 as a regulator of matrix_metalloproteinase_2 in human chondrosarcoma .
11841426	0	ETV6	0,4	AML1	11,15	ETV6	AML1	2120	861	Gene	Gene	START_ENTITY|dep|cells cells|nummod|END_ENTITY	ETV6 -LRB- TEL -RRB- - AML1 pre-B acute_lymphoblastic_leukaemia cells are associated with a distinct antigen-presenting phenotype .
26584717	0	ETV6	26,30	ANLN	106,110	ETV6	ANLN	2120	54443	Gene	Gene	gene|compound|START_ENTITY ANLN|nmod|gene Identification|nmod|ANLN Identification|dep|role role|nmod|expression expression|compound|END_ENTITY	Identification of ANLN as ETV6 partner gene in recurrent t -LRB- 7 ; 12 -RRB- -LRB- p15 ; p13 -RRB- : a possible role of deregulated ANLN expression in leukemogenesis .
26584717	0	ETV6	26,30	ANLN	18,22	ETV6	ANLN	2120	54443	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of ANLN as ETV6 partner gene in recurrent t -LRB- 7 ; 12 -RRB- -LRB- p15 ; p13 -RRB- : a possible role of deregulated ANLN expression in leukemogenesis .
23746548	0	ETV6	25,29	DCDC2	46,51	ETV6	DCDC2	2120	51473	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Alleles of a polymorphic ETV6 binding site in DCDC2 confer risk of reading and language_impairment .
20400516	0	ETV6	36,40	ETS_protein_TEL	19,34	ETV6	ETS protein TEL	2120	2120	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	DNA binding by the ETS_protein_TEL -LRB- ETV6 -RRB- is regulated by autoinhibition and self-association .
11157492	0	ETV6	32,36	TEL	27,30	ETV6	TEL	2120	2120	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Breakage and fusion of the TEL -LRB- ETV6 -RRB- gene in immature B lymphocytes induced by apoptogenic signals .
16737910	0	ETV6	56,60	TEL	62,65	ETV6	TEL	2120	2120	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification of the nuclear localization motif in the ETV6 -LRB- TEL -RRB- protein .
8695816	0	ETV6	127,131	TEL	117,120	ETV6	TEL	2120	2120	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fluorescence in situ hybridization analysis of t -LRB- 3 ; 12 -RRB- -LRB- q26 ; p13 -RRB- : a recurring chromosomal_abnormality involving the TEL gene -LRB- ETV6 -RRB- in myelodysplastic_syndromes .
9204978	0	ETV6	8,12	TEL	14,17	ETV6	TEL	2120	2120	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of ETV6 -LRB- TEL -RRB- gene rearrangements or p16INK4A/p15INK4B homozygous gene deletions in infant acute_lymphoblastic_leukemia .
9523197	0	ETV6	71,75	TEL	77,80	ETV6	TEL	2120	2120	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of new partner chromosomes involved in fusions with the ETV6 -LRB- TEL -RRB- gene in hematologic_malignancies .
21725757	0	ETa	23,26	Endothelin_receptor-A	0,21	ETa	Endothelin receptor-A	24326(Tax:10116)	24326(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Endothelin_receptor-A -LRB- ETa -RRB- inhibition fails to improve neonatal hypoxic-ischemic_brain_injury in rats .
8073632	0	EV1	65,68	gp135	26,31	EV1	gp135	11322	1272	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Sequence variation in the gp135 gene of Maedi_visna_virus_strain EV1 .
25122090	0	EVA-1	0,5	UNC-40	22,28	EVA-1	UNC-40	173355(Tax:6239)	172233(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis_elegans .
22178155	0	EVEN-SKIPPED_HOMEOBOX_1	0,23	GOOSECOID	86,95	EVEN-SKIPPED HOMEOBOX 1	GOOSECOID	2128	145258	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|repressing repressing|dobj|expression expression|amod|END_ENTITY	EVEN-SKIPPED_HOMEOBOX_1 controls human ES cell differentiation by directly repressing GOOSECOID expression .
16487602	0	EVER1	53,58	Epidermodysplasia_verruciformis_1	18,51	EVER1	Epidermodysplasia verruciformis 1	11322	11322	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Four mutations in Epidermodysplasia_verruciformis_1 -LRB- EVER1 -RRB- gene are not contributors to susceptibility in RRP .
23429285	0	EVER2	0,5	TRADD	20,25	EVER2	TRADD	147138	8717	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	EVER2 protein binds TRADD to promote TNF-a-induced apoptosis .
24257024	0	EVI	38,41	evenness_interrupted	16,36	EVI	evenness interrupted	68151(Tax:10090)	68151(Tax:10090)	Gene	Gene	Inactivation|appos|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of evenness_interrupted -LRB- EVI -RRB- reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling .
17575132	0	EVI1	32,36	RUNX1	14,19	EVI1	RUNX1	861	861	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Repression of RUNX1 activity by EVI1 : a new role of EVI1 in leukemogenesis .
22689058	0	EVI1	64,68	RUNX1	101,106	EVI1	RUNX1	2122	861	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Functional characterization of the promoter region of the human EVI1 gene in acute_myeloid_leukemia : RUNX1 and ELK1 directly regulate its transcription .
23770046	0	EVI1	59,63	SUMO1	0,5	EVI1	SUMO1	2122	7341	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic_trioxide .
18655152	0	EVI1	0,4	SUV39H1	44,51	EVI1	SUV39H1	2122	6839	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	EVI1 recruits the histone_methyltransferase SUV39H1 for transcription repression .
17635584	0	EVI1	57,61	UXT	0,3	EVI1	UXT	2122	8409	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation .
19329439	0	EVL	87,90	RAD51	46,51	EVL	RAD51	51466	5888	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Recombination activator function of the novel RAD51 - and RAD51B-binding protein , human EVL .
14560015	0	EVL-14	23,29	PDS-5	30,35	EVL-14	PDS-5	175555(Tax:6239)	855099(Tax:4932)	Gene	Gene	START_ENTITY|parataxis|essential essential|nsubj|END_ENTITY	Caenorhabditis_elegans EVL-14 / PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis .
17785435	0	EWI-2	0,5	HSPA8	40,45	EWI-2	HSPA8	93185	3312	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	EWI-2 / CD316 is an inducible receptor of HSPA8 on human dendritic cells .
25656846	0	EWI-2	0,5	TGF-b	27,32	EWI-2	TGF-b	93185	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	EWI-2 negatively regulates TGF-b signaling leading to altered melanoma growth and metastasis .
26989766	0	EWI-2	16,21	TGF-b	40,45	EWI-2	TGF-b	93185	7040	Gene	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	Novel impact of EWI-2 , CD9 , and CD81 on TGF-b signaling in melanoma .
8570200	0	EWS	14,17	CHN	26,29	EWS	CHN	2130	8013	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Fusion of the EWS gene to CHN , a member of the steroid/thyroid receptor gene superfamily , in a human myxoid_chondrosarcoma .
24185621	0	EWS	26,29	Drosha	58,64	EWS	Drosha	14030(Tax:10090)	14000(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	A multifunctional protein EWS regulates the expression of Drosha and microRNAs .
10322114	0	EWS	109,112	Pyk2	16,20	EWS	Pyk2	2130	2185	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing_sarcoma RNA-binding protein EWS .
16227627	0	EWS	157,160	SYT	22,25	EWS	SYT	2130	6857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator -LRB- SIP/CoAA -RRB- , a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins .
23831569	0	EWS	0,3	cofilin_1	14,23	EWS	cofilin 1	2130	1072	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	EWS represses cofilin_1 expression by inducing nuclear retention of cofilin_1 mRNA .
15782144	0	EWS-FLI1	44,52	PTPL1	0,5	EWS-FLI1	PTPL1	2130;2313	5783	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing 's Sarcoma_tumorigenesis .
25779942	0	EWS-FLI1	38,46	SLFN11	0,6	EWS-FLI1	SLFN11	2130;2313	91607	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing_Sarcoma .
19074838	0	EWS-Fli1	0,8	Aurora_A	40,48	EWS-Fli1	Aurora A	2130	6790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	EWS-Fli1 up-regulates expression of the Aurora_A and Aurora_B kinases .
24326851	0	EWSR1	62,67	EGFR	107,111	EWSR1	EGFR	2130	1956	Gene	Gene	rearrangement|compound|START_ENTITY rearrangement|nmod|END_ENTITY	A case of NUT midline carcinoma with no HPV_infection , slight EWSR1 rearrangement and strong expression of EGFR .
12825353	0	EXLM1	83,88	CRSP2	76,81	EXLM1	CRSP2	9282	9282	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Refinement of the physical location and the genomic characterization of the CRSP2 -LRB- EXLM1 -RRB- gene on Xp11 .4 .
23299420	0	EXPANSIN14	21,31	LBD18	35,40	EXPANSIN14	LBD18	835731(Tax:3702)	819150(Tax:3702)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Direct activation of EXPANSIN14 by LBD18 in the gene regulatory network of lateral root formation in Arabidopsis .
19008344	0	EXT2	70,74	CDKAL1	47,53	EXT2	CDKAL1	2132	54901	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	EXT2	70,74	FTO	42,45	EXT2	FTO	2132	79068	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|compound|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	EXT2	70,74	HHEX	64,68	EXT2	HHEX	2132	3087	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	EXT2	70,74	IGF2BP2	76,83	EXT2	IGF2BP2	2132	10644	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	EXT2	70,74	SLC30A8	55,62	EXT2	SLC30A8	2132	169026	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
25829497	0	EXTL2	22,27	Exostosin	45,54	EXTL2	Exostosin	2135	2131	Gene	Gene	START_ENTITY|appos|Member Member|nmod|Family Family|compound|END_ENTITY	Reduced Expression of EXTL2 , a Member of the Exostosin -LRB- EXT -RRB- Family of Glycosyltransferases , in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains .
22158612	0	EXTL3	141,146	exostosin_Tumor-like_3	117,139	EXTL3	exostosin Tumor-like 3	2137	2137	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Regenerating islet-derived 1a -LRB- Reg-1a -RRB- protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin_Tumor-like_3 -LRB- EXTL3 -RRB- receptor .
19606496	0	EYA4	0,4	SIX3	98,102	EYA4	SIX3	2070	6496	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	EYA4 , deleted in a case with middle interhemispheric variant of holoprosencephaly , interacts with SIX3 both physically and functionally .
22144423	0	EZH2	19,23	ALDH1A1	0,7	EZH2	ALDH1A1	2146	216	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	ALDH1A1 is a novel EZH2 target gene in epithelial_ovarian_cancer identified by genome-wide approaches .
27070757	0	EZH2	18,22	BCR/ABL	0,7	EZH2	BCR/ABL	14056(Tax:10090)	110279(Tax:10090)	Gene	Gene	levels|nummod|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic_myeloid_leukemia cells .
26939702	0	EZH2	15,19	BRD4	0,4	EZH2	BRD4	2146	23476	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	BRD4 regulates EZH2 transcription through up-regulation of C-MYC and represents a novel therapeutic target in bladder_cancer .
25955299	0	EZH2	57,61	CD82	27,31	EZH2	CD82	2146	3732	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Tetraspanin Family Member , CD82 , Regulates Expression of EZH2 via Inactivation of p38 MAPK Signaling in Leukemia Cells .
19340297	0	EZH2	35,39	CDKN1C	0,6	EZH2	CDKN1C	2146	1028	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CDKN1C -LRB- p57 -RRB- is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast_cancer cells .
25549357	0	EZH2	0,4	Cofilin	15,22	EZH2	Cofilin	2146	1072	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	EZH2 Regulates Cofilin Activity and Colon_Cancer Cell Migration by Targeting ITGA2 Gene .
18806826	0	EZH2	55,59	E-cadherin	14,24	EZH2	E-cadherin	2146	999	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|END_ENTITY	Repression of E-cadherin by the polycomb group protein EZH2 in cancer .
26897964	0	EZH2	0,4	E-cadherin	42,52	EZH2	E-cadherin	2146	999	Gene	Gene	Mediates|nsubj|START_ENTITY Mediates|nmod|Expression Expression|compound|END_ENTITY	EZH2 Mediates the Regulation of S100A4 on E-cadherin Expression and the Proliferation , Migration of Gastric_Cancer Cells .
20920340	0	EZH2	29,33	Enhancer_of_zeste_homolog_2	0,27	EZH2	Enhancer of zeste homolog 2	2146	2146	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Enhancer_of_zeste_homolog_2 -LRB- EZH2 -RRB- expression is an independent prognostic factor in renal_cell_carcinoma .
23677067	0	EZH2	62,66	FEZF2	0,5	EZH2	FEZF2	2146	55079	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	FEZF2 , a novel 3p14 tumor suppressor gene , represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal_carcinoma .
21777817	0	EZH2	94,98	FGF-2	0,5	EZH2	FGF-2	2146	2247	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	FGF-2 regulates cell proliferation , migration , and angiogenesis through an NDY1/KDM2B-miR -101 - EZH2 pathway .
23354591	0	EZH2	80,84	H19	20,23	EZH2	H19	2146	283120	Gene	Gene	associating|nmod|START_ENTITY increases|advcl|associating increases|nsubj|END_ENTITY	Long non-coding RNA H19 increases bladder_cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression .
27040767	0	EZH2	33,37	H19	19,22	EZH2	H19	2146	283120	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal_carcinoma .
16998811	0	EZH2	49,53	INK4A	64,69	EZH2	INK4A	2146	1029	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
18713946	0	EZH2	15,19	MYC	0,3	EZH2	MYC	2146	4609	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	MYC stimulates EZH2 expression by repression of its negative regulator miR-26a .
25939439	0	EZH2	89,93	MiR-137	0,7	EZH2	MiR-137	2146	406928	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2 .
25471249	0	EZH2	21,25	Osteopontin	0,11	EZH2	Osteopontin	2146	6696	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Osteopontin Promotes EZH2 Expression and Tumor Progression in Nasopharyngeal_Carcinoma .
26370511	0	EZH2	83,87	PARP1	43,48	EZH2	PARP1	2146	142	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Global transcriptome analysis reveals that PARP1 regulates gene expression through EZH2 .
21719208	0	EZH2	18,22	PTEN	49,53	EZH2	PTEN	2146	5728	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Overexpression of EZH2 and loss of expression of PTEN is associated with invasion , metastasis , and poor progression of gallbladder_adenocarcinoma .
26897964	0	EZH2	0,4	S100A4	32,38	EZH2	S100A4	2146	6275	Gene	Gene	Mediates|nsubj|START_ENTITY Mediates|dobj|Regulation Regulation|nmod|END_ENTITY	EZH2 Mediates the Regulation of S100A4 on E-cadherin Expression and the Proliferation , Migration of Gastric_Cancer Cells .
21232178	0	EZH2	57,61	SATB1	25,30	EZH2	SATB1	2146	6304	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells .
25644061	0	EZH2	20,24	SOX4	0,4	EZH2	SOX4	2146	6659	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal_cancer cells .
25644061	0	EZH2	20,24	SOX4	0,4	EZH2	SOX4	2146	6659	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal_cancer cells .
24132606	0	EZH2	0,4	TIMP-3	56,62	EZH2	TIMP-3	2146	7078	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	EZH2 regulates cancer cell migration through repressing TIMP-3 in non-small cell lung_cancer .
16998811	0	EZH2	49,53	VEGF	43,47	EZH2	VEGF	2146	7422	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
24986100	0	EZH2	0,4	VEGF	46,50	EZH2	VEGF	2146	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	EZH2 promotes tumor progression by increasing VEGF expression in clear_cell_renal_cell_carcinoma .
16998811	0	EZH2	49,53	WAF1	87,91	EZH2	WAF1	2146	1026	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|p21 p21|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
25499219	0	EZH2	46,50	ZBTB4	30,35	EZH2	ZBTB4	2146	57659	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis .
24697523	0	EZH2	70,74	c-Cbl_and_ERK	104,117	EZH2	c-Cbl and ERK	2146	867;5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	YC-1 inhibits proliferation of breast_cancer cells by down-regulating EZH2 expression via activation of c-Cbl_and_ERK .
16717091	0	EZH2	27,31	clock	68,73	EZH2	clock	2146	9575	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|compound|END_ENTITY	The polycomb group protein EZH2 is required for mammalian circadian clock function .
23792601	0	EZH2	43,47	enhancer_of_zeste_homolog_2	14,41	EZH2	enhancer of zeste homolog 2	2146	2146	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Inhibition of enhancer_of_zeste_homolog_2 -LRB- EZH2 -RRB- expression is associated with decreased tumor cell proliferation , migration , and invasion in endometrial_cancer cell lines .
25294424	0	EZH2	53,57	enhancer_of_zeste_human_homolog_2	18,51	EZH2	enhancer of zeste human homolog 2	2146	2146	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Overexpression of enhancer_of_zeste_human_homolog_2 -LRB- EZH2 -RRB- gene in human_cytomegalovirus positive glioblastoma multiforme tissues .
20351197	0	EZH2	35,39	estrogen_receptor	68,85	EZH2	estrogen receptor	2146	2099	Gene	Gene	methylation|compound|START_ENTITY methylation|nmod|END_ENTITY	Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen_receptor signaling to PI3K/AKT .
25225797	0	EZH2	19,23	let-7b	11,17	EZH2	let-7b	2146	406884	Gene	Gene	axis|nummod|START_ENTITY END_ENTITY|dep|axis	The KDM2B - let-7b - EZH2 axis in myelodysplastic_syndromes as a target for combined epigenetic therapy .
23599767	0	EZH2	79,83	miR-26a	0,7	EZH2	miR-26a	14056(Tax:10090)	387218(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-26a inhibits invasion and metastasis of nasopharyngeal_cancer by targeting EZH2 .
25869101	0	EZH2	73,77	microRNA-217	0,12	EZH2	microRNA-217	2146	406999	Gene	Gene	downregulating|dobj|START_ENTITY inhibits|advcl|downregulating inhibits|nsubj|END_ENTITY	microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric_cancer .
16998811	0	EZH2	49,53	p16	60,63	EZH2	p16	2146	1029	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
23289480	0	EZH2	0,4	p16	33,36	EZH2	p16	2146	1029	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	EZH2 regulates the expression of p16 in the nasopharyngeal_cancer cells .
24612037	0	EZH2	40,44	p16	139,142	EZH2	p16	14056(Tax:10090)	13088(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY depletes|nsubj|Inhibition depletes|nmod|upregulation upregulation|nmod|END_ENTITY	Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage_leukemia fusion leukemia through upregulation of p16 .
26096306	0	EZH2	0,4	p16	67,70	EZH2	p16	2146	1029	Gene	Gene	expression|nummod|START_ENTITY expression|dep|loss loss|amod|END_ENTITY	EZH2 expression in gliomas : Correlation with CDKN2A gene deletion / p16 loss and MIB-1 proliferation index .
16998811	0	EZH2	49,53	p21	83,86	EZH2	p21	2146	1026	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
16998811	0	EZH2	49,53	p27	72,75	EZH2	p27	2146	3429	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
15208672	0	EZH2	55,59	p53	10,13	EZH2	p53	2146	7157	Gene	Gene	gene|compound|START_ENTITY suppresses|dobj|gene suppresses|nsubj|END_ENTITY	Activated p53 suppresses the histone methyltransferase EZH2 gene .
16998811	0	EZH2	49,53	p53	55,58	EZH2	p53	2146	7157	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
25255445	0	EZH2	64,68	p53	14,17	EZH2	p53	2146	7157	Gene	Gene	Expression|compound|START_ENTITY Links|nmod|Expression Links|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of p53 and Rb Links the Alternative NF-kB Pathway to EZH2 Expression and Cell Senescence .
26587974	0	EZH2	19,23	p53	7,10	EZH2	p53	2146	7157	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing .
19340297	0	EZH2	35,39	p57	8,11	EZH2	p57	2146	1028	Gene	Gene	target|nmod|START_ENTITY target|nsubj|CDKN1C CDKN1C|appos|END_ENTITY	CDKN1C -LRB- p57 -RRB- is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast_cancer cells .
21205084	0	EZH2	0,4	p57	29,32	EZH2	p57	14056(Tax:10090)	12721(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	EZH2 regulates expression of p57 and contributes to progression of ovarian_cancer in vitro and in vivo .
24344012	0	EZH2	20,24	paxillin	26,34	EZH2	paxillin	2146	5829	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Prognostic value of EZH2 , paxillin expression and DNA ploidy of breast_adenocarcinoma : correlation to pathologic predictors .
14517999	0	Eaf2	46,50	ELL-associated_factor_2	21,44	Eaf2	ELL-associated factor 2	106389(Tax:10090)	106389(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of murine ELL-associated_factor_2 -LRB- Eaf2 -RRB- is developmentally regulated .
21543492	0	Eap20	32,37	Sprouty_2	0,9	Eap20	Sprouty 2	84313	10253	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Sprouty_2 binds ESCRT-II factor Eap20 and facilitates HIV-1 gag release .
21247419	0	Ear2	21,25	Rasd1	0,5	Ear2	Rasd1	13587(Tax:10090)	19416(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rasd1 interacts with Ear2 -LRB- Nr2f6 -RRB- to regulate renin transcription .
15361869	0	Early_B_cell_factor	0,19	Runx1	36,41	Early B cell factor	Runx1	1879	861	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Early_B_cell_factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription .
25378406	0	Early_Growth_Response_1	94,117	Egr1	119,123	Early Growth Response 1	Egr1	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Nucleosome-specific , Time-dependent Changes in Histone Modifications during Activation of the Early_Growth_Response_1 -LRB- Egr1 -RRB- Gene .
11784328	0	Early_growth_response-1	0,23	Egr-1	30,35	Early growth response-1	Egr-1	1958	1958	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Early_growth_response-1 gene -LRB- Egr-1 -RRB- promoter induction by ionizing radiation in U87 malignant_glioma cells in vitro .
25553923	0	Early_growth_response_2	0,23	Egr-2	25,30	Early growth response 2	Egr-2	1959	1959	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Early_growth_response_2 -LRB- Egr-2 -RRB- expression is triggered by NF-kB activation .
21228173	0	Early_growth_response_4	0,23	BDNF	33,37	Early growth response 4	BDNF	1961	627	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|compound|END_ENTITY	Early_growth_response_4 mediates BDNF induction of potassium_chloride cotransporter 2 transcription .
12021067	0	Early_growth_response_gene-1	0,28	luteinizing_hormone_receptor	65,93	Early growth response gene-1	luteinizing hormone receptor	24330(Tax:10116)	25477(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Early_growth_response_gene-1 regulates the expression of the rat luteinizing_hormone_receptor gene .
25725290	0	Early_growth_response_gene_1	0,28	TRBP	32,36	Early growth response gene 1	TRBP	1958	6895	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Early_growth_response_gene_1 , a TRBP binding protein , is involved in miRNA activity of miR-125a-3p in human cells .
12890669	0	Early_growth_response_gene_1	0,28	androgen_receptor	39,56	Early growth response gene 1	androgen receptor	1958	367	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Early_growth_response_gene_1 modulates androgen_receptor signaling in prostate_carcinoma cells .
14630787	0	Early_hematopoietic_zinc_finger_protein	0,39	Evi3	75,79	Early hematopoietic zinc finger protein	Evi3	25925	225207(Tax:10090)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Early_hematopoietic_zinc_finger_protein -LRB- EHZF -RRB- , the human homolog to mouse Evi3 , is highly expressed in primitive human hematopoietic cells .
7927265	0	Early_pregnancy_factor	0,22	chaperonin_10	98,111	Early pregnancy factor	chaperonin 10	3336	25462(Tax:10116)	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Early_pregnancy_factor in liver_regeneration after partial hepatectomy in rats : relationship with chaperonin_10 .
25455103	0	Ebf1	20,24	Shh	0,3	Ebf1	Shh	395512(Tax:9031)	395615(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Shh regulates chick Ebf1 gene expression in somite development .
24111778	0	Ebf2	21,25	Bmp4	0,4	Ebf2	Bmp4	395176(Tax:9031)	396165(Tax:9031)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Bmp4 regulates chick Ebf2 and Ebf3 gene expression in somite development .
27073743	0	Ebi	0,3	TBL1	31,35	Ebi	TBL1	33212(Tax:7227)	33212(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Ebi , a Drosophila homologue of TBL1 , regulates the balance between cellular defense responses and neuronal survival .
16642037	0	Ebp1	47,51	Akt	8,11	Ebp1	Akt	81736(Tax:10116)	24185(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Nuclear Akt associates with PKC-phosphorylated Ebp1 , preventing DNA fragmentation by inhibition of caspase-activated_DNase .
16254079	0	Ebp1	26,30	E2F1	63,67	Ebp1	E2F1	5036	1869	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription .
17316401	0	Ebp1	38,42	Protein_kinase_C-delta	0,22	Ebp1	Protein kinase C-delta	5036	5580	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Protein_kinase_C-delta phosphorylates Ebp1 and prevents its proteolytic degradation , enhancing cell survival .
16254079	0	Ebp1	26,30	Sin3A	46,51	Ebp1	Sin3A	5036	25942	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription .
23975429	0	Ebp1	0,4	podoplanin	15,25	Ebp1	podoplanin	5036	10630	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Ebp1 activates podoplanin expression and contributes to oral tumorigenesis .
18603780	0	Ebp2p	29,34	Ris1p	140,145	Ebp2p	Ris1p	853682(Tax:4932)	854363(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	SUMO mediates interaction of Ebp2p , the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2 , with a RING finger protein Ris1p .
15233798	0	EcR	60,63	E75	70,73	EcR	E75	692756(Tax:7091)	692595(Tax:7091)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR , HR3 , E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera .
15233798	0	EcR	60,63	HR3	65,68	EcR	HR3	692756(Tax:7091)	692562(Tax:7091)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR , HR3 , E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera .
10757764	0	EcR	34,37	ecdysone_receptor	15,32	EcR	ecdysone receptor	35540(Tax:7227)	35540(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Drosophila ecdysone_receptor -LRB- EcR -RRB- gene is required maternally for normal oogenesis .
10851134	0	EcR	83,86	ecdysone_receptor	64,81	EcR	ecdysone receptor	35540(Tax:7227)	35540(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A conditional rescue system reveals essential functions for the ecdysone_receptor -LRB- EcR -RRB- gene during molting and metamorphosis in Drosophila .
25634994	0	EcSOD	14,19	SOD3	8,12	EcSOD	SOD3	6649	6649	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Loss of SOD3 -LRB- EcSOD -RRB- Expression Promotes an Aggressive Phenotype in Human Pancreatic_Ductal_Adenocarcinoma .
8798704	0	Eca39	119,124	myc	96,99	Eca39	myc	856615(Tax:4932)	4609	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Mitochondrial and cytosolic branched-chain amino_acid transaminases from yeast , homologs of the myc oncogene-regulated Eca39 protein .
17239346	0	Ecdysone	0,8	MsrA	22,26	Ecdysone	MsrA	38291(Tax:7227)	39675(Tax:7227)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Ecdysone induction of MsrA protects against oxidative stress in Drosophila .
9733765	0	Eck	34,37	EphA2	27,32	Eck	EphA2	13836(Tax:10090)	13836(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	An enhancer element in the EphA2 -LRB- Eck -RRB- gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins .
24386507	0	Ect2	12,16	RhoGEF	25,31	Ect2	RhoGEF	1894	64283	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	The Role of Ect2 Nuclear RhoGEF Activity in Ovarian_Cancer_Cell_Transformation .
22833125	0	Ectodysplasin	0,13	Fgf20	88,93	Ectodysplasin	Fgf20	13607(Tax:10090)	80857(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling .
24508088	0	Ectodysplasin_A	0,15	EDA	24,27	Ectodysplasin A	EDA	1896	1896	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	Ectodysplasin_A -LRB- EDA -RRB- - EDA receptor signalling and its pharmacological modulation .
16481354	0	EdaR	27,31	Shh	55,58	EdaR	Shh	13608(Tax:10090)	20423(Tax:10090)	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	NF-kappaB transmits Eda_A1 / EdaR signalling to activate Shh and cyclin_D1 expression , and controls post-initiation hair placode down growth .
11673450	1	Edg-1	124,129	Edg-3	99,104	Edg-1	Edg-3	1901	1903	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation through Edg-3 and Edg-5 , but not Edg-1 , in human embryonic kidney 293 cells .
14688232	0	Edg-1	117,122	S1P1	123,127	Edg-1	S1P1	1901	1901	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1 / S1P1 receptor .
11673450	1	Edg-3	99,104	Edg-1	124,129	Edg-3	Edg-1	1903	1901	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation through Edg-3 and Edg-5 , but not Edg-1 , in human embryonic kidney 293 cells .
12392575	0	Edg78E	51,57	BetaFTZ-F1	0,10	Edg78E	BetaFTZ-F1	40354(Tax:7227)	40045(Tax:7227)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|dobj|activation	BetaFTZ-F1 dependent and independent activation of Edg78E , a pupal cuticle gene , during the early metamorphic period in Drosophila_melanogaster .
21073867	0	Edn1	16,20	Alcama	0,6	Edn1	Alcama	58032(Tax:7955)	30194(Tax:7955)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis .
9804998	0	Edp1	84,88	endothelial_protein_1	61,82	Edp1	endothelial protein 1	21927(Tax:10090)	21927(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and chromosomal mapping of the TNF-alpha inducible endothelial_protein_1 -LRB- Edp1 -RRB- gene in the mouse .
11369454	0	Edpm5	54,59	MMP-9	34,39	Edpm5	MMP-9	326390(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of estrogen-dependent MMP-9 expression by Edpm5 , a genetic locus for pituitary_tumor growth in rat .
23821546	0	Eed	137,140	embryonic_ectoderm_development	105,135	Eed	embryonic ectoderm development	13626(Tax:10090)	13626(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 -LRB- PRC2 -RRB- via targeting the mRNA of embryonic_ectoderm_development -LRB- Eed -RRB- gene in mouse embryonic stem cells .
25001410	0	Efg1	0,4	ACE2	24,28	Efg1	ACE2	853188(Tax:4932)	850822(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Efg1 directly regulates ACE2 expression to mediate cross talk between the cAMP/PKA and RAM pathways during Candida_albicans morphogenesis .
15130519	0	Efp	61,64	estrogen-responsive_finger_protein	25,59	Efp	estrogen-responsive finger protein	7706	7706	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Systemic distribution of estrogen-responsive_finger_protein -LRB- Efp -RRB- in human tissues .
16140366	0	Efp	50,53	estrogen-responsive_finger_protein	14,48	Efp	estrogen-responsive finger protein	7706	7706	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of estrogen-responsive_finger_protein -LRB- Efp -RRB- is associated with advanced_disease in human epithelial ovarian_cancer .
19148513	0	Efp	102,105	vascular_endothelial_growth_factor	18,52	Efp	vascular endothelial growth factor	7706	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the vascular_endothelial_growth_factor and growth by estrogen and antiestrogens through Efp in Ishikawa endometrial_carcinoma cells .
16342954	0	Eg5	20,23	ATPase	0,6	Eg5	ATPase	3832	1769	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	ATPase mechanism of Eg5 in the absence of microtubules : insight into microtubule activation and allosteric inhibition by monastrol .
20826821	0	Eg5	32,35	Lamin_B	0,7	Eg5	Lamin B	397908(Tax:8355)	379745(Tax:8355)	Gene	Gene	counteracts|dobj|START_ENTITY counteracts|nsubj|END_ENTITY	Lamin_B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly .
21969468	0	Eg5	48,51	TPX2	0,4	Eg5	TPX2	3832	22974	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle .
26018074	0	Eg5	14,17	TPX2	0,4	Eg5	TPX2	3832	22974	Gene	Gene	START_ENTITY|nsubj|Inhibits Inhibits|compound|END_ENTITY	TPX2 Inhibits Eg5 by Interactions with both Motor and Microtubule .
26018074	0	Eg5	14,17	TPX2	0,4	Eg5	TPX2	3832	22974	Gene	Gene	START_ENTITY|nsubj|Inhibits Inhibits|compound|END_ENTITY	TPX2 Inhibits Eg5 by Interactions with both Motor and Microtubule .
26009097	1	Egfl7	31,36	EGF-like_domain_7	12,29	Egfl7	EGF-like domain 7	678640(Tax:7955)	51162	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of EGF-like_domain_7 -LRB- Egfl7 -RRB- in placental development and implantation .
26490843	0	Egfr	162,166	Epidermal_Growth_Factor_Receptor	128,160	Egfr	Epidermal Growth Factor Receptor	378478(Tax:7955)	378478(Tax:7955)	Gene	Gene	Pathway|appos|START_ENTITY Pathway|compound|END_ENTITY	Bisphenol_A and Related_Alkylphenols Exert Nongenomic Estrogenic Actions Through a G_Protein-Coupled_Estrogen_Receptor_1 -LRB- Gper -RRB- / Epidermal_Growth_Factor_Receptor -LRB- Egfr -RRB- Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes .
26532455	0	Egfr	189,193	Epidermal_Growth_Factor_Receptor	155,187	Egfr	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	The Impact Of First-Line Tyrosine Kinase Inhibitors -LRB- Tkis -RRB- On Overall Survival In Patients With Advanced_Non-Small_Cell_Lung_Cancer -LRB- Nsclc -RRB- And Activating Epidermal_Growth_Factor_Receptor -LRB- Egfr -RRB- Mutations : Meta-Analysis Of Major Randomized Trials By Mutation Type .
26534371	0	Egfr	261,265	Epidermal_Growth_Factor_Receptor	227,259	Egfr	Epidermal Growth Factor Receptor	1956	1956	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Cost Distribution Analysis Related to the Use of Tyrisine-Kinase Inhibitors -LRB- Tki -RRB- and the Combination of Pemetrexed/Cisplatin in the Treatment of Non-Small_Cell_Lung_Cancer -LRB- Nsclc -RRB- Locally Advanced or Metastatic in Presence of Epidermal_Growth_Factor_Receptor -LRB- Egfr -RRB- Mutations in a Mexican Institutional Context .
11866425	0	Egfr	122,126	Gurken	0,6	Egfr	Gurken	37455(Tax:7227)	34171(Tax:7227)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Gurken , a TGF-alpha-like protein involved in axis_determination in Drosophila , directly binds to the EGF-receptor homolog Egfr .
18719024	0	Egr-1	81,86	ATF3	44,48	Egr-1	ATF3	1958	467	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the transcriptional repressor ATF3 in gonadotrophs is regulated by Egr-1 , CREB , and ATF2 after gonadotropin-releasing_hormone_receptor stimulation .
18469860	0	Egr-1	22,27	BAG3	14,18	Egr-1	BAG3	1958	9531	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells .
16267018	0	Egr-1	82,87	Bombesin	0,8	Egr-1	Bombesin	1958	2922	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Bombesin regulates cyclin_D1 expression through the early_growth_response_protein Egr-1 in prostate_cancer cells .
22593050	0	Egr-1	0,5	DARPP-32	14,22	Egr-1	DARPP-32	24330(Tax:10116)	360616(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element .
11784328	0	Egr-1	30,35	Early_growth_response-1	0,23	Egr-1	Early growth response-1	1958	1958	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Early_growth_response-1 gene -LRB- Egr-1 -RRB- promoter induction by ionizing radiation in U87 malignant_glioma cells in vitro .
11535237	0	Egr-1	80,85	Epidermal_growth_factor	0,23	Egr-1	Epidermal growth factor	1958	1950	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Epidermal_growth_factor and platelet-derived growth factor induce expression of Egr-1 , a zinc finger transcription factor , in human malignant_glioma cells .
22198237	0	Egr-1	61,66	FGF2	67,71	Egr-1	FGF2	1958	2247	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	MG624 , an a7-nAChR antagonist , inhibits angiogenesis via the Egr-1 / FGF2 pathway .
10669633	0	Egr-1	33,38	Flt-1	49,54	Egr-1	Flt-1	1958	2321	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Zinc finger transcription factor Egr-1 activates Flt-1 gene expression in THP-1 cells on induction for macrophage differentiation .
2005129	0	Egr-1	87,92	Granulocyte-macrophage_colony-stimulating_factor	0,48	Egr-1	Granulocyte-macrophage colony-stimulating factor	13653(Tax:10090)	12981(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor induces transcriptional activation of Egr-1 in murine peritoneal macrophages .
19526316	0	Egr-1	64,69	Hepatocyte_growth_factor	0,24	Egr-1	Hepatocyte growth factor	1958	3082	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Hepatocyte_growth_factor induced up-regulations of VEGF through Egr-1 in hepatocellular_carcinoma cells .
17631285	0	Egr-1	62,67	Id2	27,30	Egr-1	Id2	1958	3398	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Interleukin-1_beta-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells .
9418958	0	Egr-1	70,75	Krox-20	49,56	Egr-1	Krox-20	13653(Tax:10090)	13654(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Differential regulation of the zinc finger genes Krox-20 and Krox-24 -LRB- Egr-1 -RRB- suggests antagonistic roles in Schwann cells .
16530935	0	Egr-1	59,64	LHbeta	33,39	Egr-1	LHbeta	13653(Tax:10090)	16866(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Insulin augments GnRH-stimulated LHbeta gene expression by Egr-1 .
23478574	0	Egr-1	0,5	MDR1	62,66	Egr-1	MDR1	1958	5243	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|modulating modulating|dobj|expression expression|compound|END_ENTITY	Egr-1 enhances drug resistance of breast_cancer by modulating MDR1 expression in a GGPPS-independent manner .
17174939	0	Egr-1	76,81	NAB2	44,48	Egr-1	NAB2	1958	4665	Gene	Gene	corepressors|nmod|START_ENTITY isoforms|acl:relcl|corepressors isoforms|nmod|END_ENTITY	FGF23 induces expression of two isoforms of NAB2 , which are corepressors of Egr-1 .
18203138	0	Egr-1	42,47	NAB2	48,52	Egr-1	NAB2	13653(Tax:10090)	17937(Tax:10090)	Gene	Gene	Egr-3|amod|START_ENTITY Egr-3|dep|END_ENTITY	Opposing regulation of T cell function by Egr-1 / NAB2 and Egr-2 / Egr-3 .
8668170	0	Egr-1	31,36	NAB2	0,4	Egr-1	NAB2	1958	4665	Gene	Gene	corepressor|nmod|START_ENTITY END_ENTITY|appos|corepressor	NAB2 , a corepressor of NGFI-A -LRB- Egr-1 -RRB- and Krox20 , is induced by proliferative and differentiative stimuli .
10640682	0	Egr-1	22,27	NGFI-A	14,20	Egr-1	NGFI-A	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of NGFI-A -LRB- Egr-1 -RRB- gene expression by the POU domain transcription factor Brn-3a .
15147836	0	Egr-1	35,40	Neuregulin-1	0,12	Egr-1	Neuregulin-1	1958	3084	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Neuregulin-1 induces expression of Egr-1 and activates acetylcholine receptor transcription through an Egr-1-binding site .
22138429	0	Egr-1	20,25	Neurotensin	0,11	Egr-1	Neurotensin	13653(Tax:10090)	67405(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nummod|END_ENTITY	Neurotensin induced Egr-1 activity is altered in the postpartum period in mice .
18723570	0	Egr-1	97,102	PDGF-B	41,47	Egr-1	PDGF-B	24330(Tax:10116)	24628(Tax:10116)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Mycophenolic_acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells .
19769948	0	Egr-1	18,23	Prolactin	0,9	Egr-1	Prolactin	24330(Tax:10116)	24683(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Prolactin induces Egr-1 gene expression in cultured hypothalamic cells and in the rat hypothalamus .
18390831	0	Egr-1	67,72	RAGE	0,4	Egr-1	RAGE	13653(Tax:10090)	11596(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	RAGE : developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells .
24451137	0	Egr-1	0,5	Siva-1	18,24	Egr-1	Siva-1	1958	10572	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Egr-1 upregulates Siva-1 expression and induces cardiac fibroblast apoptosis .
27099350	0	Egr-1	34,39	SphK1	13,18	Egr-1	SphK1	1958	8877	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	PDGF Induces SphK1 Expression via Egr-1 to Promote Pulmonary Artery Smooth Muscle Cell Proliferation .
25224321	0	Egr-1	101,106	TGF-b1	35,41	Egr-1	TGF-b1	1958	7040	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of increased levels of TGF-b1 and p14ARF in prostate_carcinoma cell lines overexpressing Egr-1 .
11997234	0	Egr-1	76,81	TNF-alpha	51,60	Egr-1	TNF-alpha	13653(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1 .
20653771	0	Egr-1	71,76	TNF-alpha	17,26	Egr-1	TNF-alpha	1958	7124	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Up-regulation Up-regulation|nmod|secretion secretion|amod|END_ENTITY	Up-regulation of TNF-alpha secretion by cigarette smoke is mediated by Egr-1 in HaCaT human keratinocytes .
9542779	0	Egr-1	43,48	TNF-alpha	0,9	Egr-1	TNF-alpha	1958	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TNF-alpha induces the transcription factor Egr-1 , pro-inflammatory cytokines and cell proliferation in human skin fibroblasts and synovial lining cells .
20621662	0	Egr-1	24,29	T_beta_R-II	40,51	Egr-1	T beta R-II	1958	7048	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Cigarette smoke-induced Egr-1 represses T_beta_R-II expression in human skin dermal fibroblasts .
18378044	0	Egr-1	0,5	TrkA	37,41	Egr-1	TrkA	1958	4914	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Egr-1 and Hipk2 are required for the TrkA to p75 -LRB- NTR -RRB- switch that occurs downstream of IGF1-R .
8702507	0	Egr-1	0,5	basic_fibroblast_growth_factor	16,46	Egr-1	basic fibroblast growth factor	1958	2247	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	Egr-1 activates basic_fibroblast_growth_factor transcription .
19940138	0	Egr-1	44,49	c-Jun	0,5	Egr-1	c-Jun	100009491(Tax:9986)	100008856(Tax:9986)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	c-Jun regulates shear - and injury-inducible Egr-1 expression , vein graft stenosis after autologous end-to-side transplantation in rabbits , and intimal hyperplasia in human saphenous veins .
16267018	0	Egr-1	82,87	cyclin_D1	19,28	Egr-1	cyclin D1	1958	595	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Bombesin regulates cyclin_D1 expression through the early_growth_response_protein Egr-1 in prostate_cancer cells .
8466649	0	Egr-1	79,84	early_growth_response-1	54,77	Egr-1	early growth response-1	1958	1958	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Characterization of the DNA-binding properties of the early_growth_response-1 -LRB- Egr-1 -RRB- transcription factor : evidence for modulation by a redox mechanism .
21725089	0	Egr-1	51,56	early_growth_response_1	26,49	Egr-1	early growth response 1	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Diurnal regulation of the early_growth_response_1 -LRB- Egr-1 -RRB- protein expression by hepatocyte nuclear factor 4alpha -LRB- HNF4alpha -RRB- and small heterodimer partner -LRB- SHP -RRB- cross-talk in liver fibrosis .
22542571	0	Egr-1	73,78	early_growth_response_1	48,71	Egr-1	early growth response 1	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Social isolation stress down-regulates cortical early_growth_response_1 -LRB- Egr-1 -RRB- expression in mice .
15078886	0	Egr-1	176,181	early_growth_response_factor-1	144,174	Egr-1	early growth response factor-1	1958	1958	Gene	Gene	accumulation|compound|START_ENTITY accumulation|amod|END_ENTITY	ERK1/2 associates with the c-Met-binding domain of growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- - associated_binder-1 -LRB- Gab1 -RRB- : role in ERK1/2 and early_growth_response_factor-1 -LRB- Egr-1 -RRB- nuclear accumulation .
8855340	0	Egr-1	15,20	extracellular_signal-regulated_kinase	106,143	Egr-1	extracellular signal-regulated kinase	13653(Tax:10090)	26413(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY mediated|nsubjpass|transcription mediated|nmod|activation activation|amod|END_ENTITY	Urea-inducible Egr-1 transcription in renal inner medullary collecting duct -LRB- mIMCD3 -RRB- cells is mediated by extracellular_signal-regulated_kinase activation .
12637574	0	Egr-1	0,5	interleukin-1beta	73,90	Egr-1	interleukin-1beta	1958	3553	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta .
19385085	0	Egr-1	0,5	leptin	46,52	Egr-1	leptin	24330(Tax:10116)	25608(Tax:10116)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|effect effect|nmod|END_ENTITY	Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro .
16260776	0	Egr-1	0,5	nab2	48,52	Egr-1	nab2	1958	4665	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop .
16260776	0	Egr-1	0,5	nab2	74,78	Egr-1	nab2	1958	4665	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|establishing establishing|nsubj|activation activation|nmod|promoter promoter|amod|END_ENTITY	Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop .
11035041	0	Egr-1	57,62	p53	34,37	Egr-1	p53	13653(Tax:10090)	22060(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Ionizing radiation down-regulates p53 protein in primary Egr-1 - / - mouse embryonic fibroblast cells causing enhanced resistance to apoptosis .
7744747	0	Egr-1	29,34	phenylethanolamine_N-methyltransferase	60,98	Egr-1	phenylethanolamine N-methyltransferase	24330(Tax:10116)	24661(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of transcription factor Egr-1 in phorbol_ester-induced phenylethanolamine_N-methyltransferase gene expression .
12379479	0	Egr-1	14,19	proteasome_component_C8	44,67	Egr-1	proteasome component C8	1958	5684	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Egr-1 by association with the proteasome_component_C8 .
1730654	0	Egr-1	18,23	tumor_necrosis_factor	32,53	Egr-1	tumor necrosis factor	1958	7124	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the Egr-1 gene by tumor_necrosis_factor and interferons in primary human fibroblasts .
20332214	0	Egr-1	21,26	tumor_necrosis_factor_alpha	96,123	Egr-1	tumor necrosis factor alpha	1958	7124	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Transcription factor Egr-1 is essential for maximal matrix_metalloproteinase-9 transcription by tumor_necrosis_factor_alpha .
1408148	0	Egr-1	32,37	v-Raf	50,55	Egr-1	v-Raf	13653(Tax:10090)	110157(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements .
15737464	0	Egr-1	71,76	vascular_endothelial_growth_factor	32,66	Egr-1	vascular endothelial growth factor	24330(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Prolactin-induced expression of vascular_endothelial_growth_factor via Egr-1 .
15805312	0	Egr-1	55,60	zif268	62,68	Egr-1	zif268	1958	1958	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the immediate-early gene-encoded protein Egr-1 -LRB- zif268 -RRB- during in vitro classical conditioning .
25553923	0	Egr-2	25,30	Early_growth_response_2	0,23	Egr-2	Early growth response 2	1959	1959	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Early_growth_response_2 -LRB- Egr-2 -RRB- expression is triggered by NF-kB activation .
9915863	0	Egr-2	8,13	Fas_ligand	34,44	Egr-2	Fas ligand	1959	356	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Role of Egr-2 in up-regulation of Fas_ligand in normal T cells and aberrant double-negative lpr and gld T cells .
9632757	0	Egr-3	45,50	Fas_ligand	61,71	Egr-3	Fas ligand	1960	356	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas_ligand expression .
22390138	0	Egr1	92,96	Atf3	112,116	Egr1	Atf3	1958	467	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes : Egr1 is a principal Atf3 target .
11331872	0	Egr1	75,79	ERK	0,3	Egr1	ERK	24330(Tax:10116)	24338(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	ERK induces p35 , a neuron-specific activator of Cdk5 , through induction of Egr1 .
25378406	0	Egr1	119,123	Early_Growth_Response_1	94,117	Egr1	Early Growth Response 1	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Nucleosome-specific , Time-dependent Changes in Histone Modifications during Activation of the Early_Growth_Response_1 -LRB- Egr1 -RRB- Gene .
19017967	0	Egr2	0,4	Bcl-2	21,26	Egr2	Bcl-2	1959	596	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	Egr2 is required for Bcl-2 induction during positive selection .
24121514	0	Elastin	0,7	cathepsin_V	23,34	Elastin	cathepsin V	2006	1515	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	Elastin degradation by cathepsin_V requires two exosites .
16922949	0	Elastin	0,7	lysozyme	77,85	Elastin	lysozyme	2006	4069	Gene	Gene	changes|compound|START_ENTITY changes|dep|role role|nmod|END_ENTITY	Elastin changes during chronological and photo-ageing : the important role of lysozyme .
10347164	0	Elf-1	21,26	CD4	30,33	Elf-1	CD4	1997	920	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	A potential role for Elf-1 in CD4 promoter function .
7935370	0	Elf-1	0,5	CD4	46,49	Elf-1	CD4	13709(Tax:10090)	12504(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|element element|nmod|enhancer enhancer|compound|END_ENTITY	Elf-1 binds to a critical element in a second CD4 enhancer .
9010230	0	Elf-1	18,23	MDK1	90,94	Elf-1	MDK1	13709(Tax:10090)	13841(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Elf-1 and B61 as high affinity ligands for the receptor_tyrosine_kinase MDK1 .
8895518	0	Elf-1	42,47	MEF	0,3	Elf-1	MEF	1997	2000	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	MEF , a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties .
23284001	0	Elf-1	108,113	hPygopus2	83,92	Elf-1	hPygopus2	1997	90780	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Human_papilloma_virus -LRB- HPV -RRB- E7-mediated attenuation of retinoblastoma -LRB- Rb -RRB- induces hPygopus2 expression via Elf-1 in cervical_cancer .
8887642	0	Elf-1	21,26	terminal_transferase	30,50	Elf-1	terminal transferase	1997	1791	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|amod|END_ENTITY	A potential role for Elf-1 in terminal_transferase gene regulation .
25047565	0	Elfn1	0,5	mGluR7	27,33	Elfn1	mGluR7	243312(Tax:10090)	14807(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures .
18247360	0	Elk-1	0,5	FAK	22,25	Elk-1	FAK	2002	5747	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Elk-1 associates with FAK , regulates the expression of FAK and MAP kinases as well as apoptosis in HK-2 cells .
20680465	0	Elk1	44,48	AC3-33	0,6	Elk1	AC3-33	2002	285315	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	AC3-33 , a novel secretory protein , inhibits Elk1 transcriptional activity via ERK pathway .
12890647	0	Elk1	55,59	KCNH8	48,53	Elk1	KCNH8	2002	131096	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Distribution and functional properties of human KCNH8 -LRB- Elk1 -RRB- potassium channels .
26540344	0	Ell3	0,4	p53	16,19	Ell3	p53	80237	7157	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and - independent proteasomal degradation pathways in breast_cancer cells .
15278943	0	Ellis-van_Creveld	18,35	Evc	37,40	Ellis-van Creveld	Evc	289712(Tax:10116)	289712(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the Ellis-van_Creveld -LRB- Evc -RRB- gene in the rat tibial growth plate .
16861226	0	Elm1	71,75	Gin4	63,67	Elm1	Gin4	853818(Tax:4932)	852119(Tax:4932)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast .
15347785	0	Elm1	4,8	ZmHy2	10,15	Elm1	ZmHy2	542164(Tax:4577)	542164(Tax:4577)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Elm1 -LRB- ZmHy2 -RRB- gene of maize encodes a phytochromobilin_synthase .
25572395	0	Elmo2	24,29	ClipR-59	0,8	Elmo2	ClipR-59	140579(Tax:10090)	76686(Tax:10090)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	ClipR-59 Interacts with Elmo2 and Modulates Myoblast Fusion .
2571575	0	Elo	69,72	eye_lens_obsolescence	46,67	Elo	eye lens obsolescence	12968(Tax:10090)	12968(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Linkage analysis of the mutation locus in the eye_lens_obsolescence -LRB- Elo -RRB- mouse .
12943681	0	EloA-BP1	18,26	Elongin_A	36,45	EloA-BP1	Elongin A	57455	6924	Gene	Gene	Identification|nmod|START_ENTITY Identification|appos|protein protein|compound|END_ENTITY	Identification of EloA-BP1 , a novel Elongin_A binding protein with an exonuclease homology domain .
12943681	0	Elongin_A	36,45	EloA-BP1	18,26	Elongin A	EloA-BP1	6924	57455	Gene	Gene	protein|compound|START_ENTITY Identification|appos|protein Identification|nmod|END_ENTITY	Identification of EloA-BP1 , a novel Elongin_A binding protein with an exonuclease homology domain .
13679363	0	ElrA	60,64	HuR	89,92	ElrA	HuR	495680(Tax:8355)	495680(Tax:8355)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Xenopus_cold-inducible_RNA-binding_protein_2 interacts with ElrA , the Xenopus homolog of HuR , and inhibits deadenylation of specific mRNAs .
13679363	0	ElrA	60,64	Xenopus_cold-inducible_RNA-binding_protein_2	0,44	ElrA	Xenopus cold-inducible RNA-binding protein 2	495680(Tax:8355)	379484(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Xenopus_cold-inducible_RNA-binding_protein_2 interacts with ElrA , the Xenopus homolog of HuR , and inhibits deadenylation of specific mRNAs .
1545809	0	Embryonal_long_terminal_repeat-binding_protein	0,46	FTZ-F1	70,76	Embryonal long terminal repeat-binding protein	FTZ-F1	26423(Tax:10090)	26423(Tax:10090)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Embryonal_long_terminal_repeat-binding_protein is a murine homolog of FTZ-F1 , a member of the steroid receptor superfamily .
21525034	0	Emerin	0,6	Pax3	36,40	Emerin	Pax3	2010	5077	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|binding binding|nmod|END_ENTITY	Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes .
17159919	0	Emi1	16,20	Pin1	0,4	Emi1	Pin1	26271	5300	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF -LRB- betatrcp -RRB- .
23645673	0	Emi1	57,61	early_mitotic_inhibitor_1	30,55	Emi1	early mitotic inhibitor 1	26271	26271	Gene	Gene	depletion|appos|START_ENTITY depletion|amod|END_ENTITY	Selective enhancing effect of early_mitotic_inhibitor_1 -LRB- Emi1 -RRB- depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells .
17276914	0	Emi2	49,53	Cdc2	11,15	Emi2	Cdc2	286151	983	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|amod|END_ENTITY	A role for Cdc2 - and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest .
26459104	0	Emi2	36,40	Polo-like_kinase_1	44,62	Emi2	Polo-like kinase 1	286151	5347	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recognition of Emi2 by Polo-like_kinase_1 and development of peptidomimetics blocking oocyte maturation and fertilization .
16530037	0	Emilin1	23,30	TGF-beta	0,8	Emilin1	TGF-beta	100952(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	TGF-beta regulation by Emilin1 : new links in the etiology of hypertension .
16530041	0	Emilin1	0,7	TGF-beta	14,22	Emilin1	TGF-beta	100952(Tax:10090)	21803(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|maturation maturation|amod|END_ENTITY	Emilin1 links TGF-beta maturation to blood pressure homeostasis .
24131633	0	Emilin3	0,7	Scube2	70,76	Emilin3	Scube2	101882042	503728(Tax:7955)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Emilin3 is required for notochord_sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals .
18501646	0	Emp	49,52	erythroblast-macrophage_protein	16,47	Emp	erythroblast-macrophage protein	59003(Tax:10090)	59003(Tax:10090)	Gene	Gene	Requirement|appos|START_ENTITY Requirement|nmod|END_ENTITY	Requirement for erythroblast-macrophage_protein -LRB- Emp -RRB- in definitive erythropoiesis .
18854508	0	Emx2	0,4	odorant_receptor	16,32	Emx2	odorant receptor	13797(Tax:10090)	259026(Tax:10090)	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Emx2 stimulates odorant_receptor gene expression .
9342190	0	En-1	35,39	Engrailed	24,33	En-1	Engrailed	771008(Tax:9031)	771008(Tax:9031)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	The homeobox-containing Engrailed -LRB- En-1 -RRB- product down-regulates the expression of Pax-6 through a DNA binding-independent mechanism .
15242796	0	En1	0,3	Dkk1	28,32	En1	Dkk1	13798(Tax:10090)	13380(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	En1 and Wnt7a interact with Dkk1 during limb development in the mouse .
10646796	0	En1	52,55	FGF10	0,5	En1	FGF10	771008(Tax:9031)	395432(Tax:9031)	Gene	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm , independent of its dorsoventral specification .
10646796	0	En1	52,55	Fgf8	17,21	En1	Fgf8	771008(Tax:9031)	396313(Tax:9031)	Gene	Gene	induce|nmod|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm , independent of its dorsoventral specification .
26116879	0	Enah	44,48	Sh3bgr	27,33	Enah	Sh3bgr	13800(Tax:10090)	50795(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	A thioredoxin fold protein Sh3bgr regulates Enah and is necessary for proper sarcomere formation .
26116879	0	Enah	44,48	Sh3bgr	27,33	Enah	Sh3bgr	13800(Tax:10090)	50795(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	A thioredoxin fold protein Sh3bgr regulates Enah and is necessary for proper sarcomere formation .
22991144	0	Encephalopsin	0,13	OPN3	15,19	Encephalopsin	OPN3	13603(Tax:10090)	13603(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Encephalopsin -LRB- OPN3 -RRB- protein abundance in the adult mouse brain .
26567111	0	Endo180	17,24	LOX	50,53	Endo180	LOX	9902	4015	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic_prostate_cancer cell migration on human ECM surfaces .
19112015	0	Endo180	0,7	MT1-MMP	46,53	Endo180	MT1-MMP	9902	4323	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate_cancer progression .
12952933	0	Endo180	27,34	uPAR	13,17	Endo180	uPAR	9902	5329	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis .
26927690	0	Endocan	56,63	Endothelial_Cell-Specific_Molecule_1	18,54	Endocan	Endothelial Cell-Specific Molecule 1	11082	11082	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	Analysis of Serum Endothelial_Cell-Specific_Molecule_1 -LRB- Endocan -RRB- Level in Type_2_Diabetes_Mellitus With Acute ST-Segment Elevation Myocardial_Infarction and its Correlation : A Pilot Study .
24871583	0	Endocan	25,32	Vascular_Endothelial_Growth_Factor	106,140	Endocan	Vascular Endothelial Growth Factor	11082	7422	Gene	Gene	Upregulated|nsubjpass|START_ENTITY Upregulated|nmod|END_ENTITY	The Angiogenic Biomarker Endocan is Upregulated in Proliferative Diabetic_Retinopathy and Correlates with Vascular_Endothelial_Growth_Factor .
19736306	0	Endoglin	0,8	ALK2	28,32	Endoglin	ALK2	2022	90	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Endoglin phosphorylation by ALK2 contributes to the regulation of prostate_cancer cell migration .
23300529	0	Endoglin	0,8	BMP9	25,29	Endoglin	BMP9	2022	2658	Gene	Gene	requirement|compound|START_ENTITY requirement|nmod|END_ENTITY	Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies .
16484587	0	Endoglin	0,8	Fli-1	55,60	Endoglin	Fli-1	13805(Tax:10090)	14247(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Endoglin expression in the endothelium is regulated by Fli-1 , Erg , and Elf-1 acting on the promoter and a -8 - kb enhancer .
20833252	0	Endoglin	0,8	Smad2/3	48,55	Endoglin	Smad2/3	2022	4087;4088	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Endoglin differentially regulates TGF-b-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes .
20878063	0	Endoglin	23,31	TGF-b1	58,64	Endoglin	TGF-b1	2022	7040	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abnormal expression of Endoglin and its receptor complex -LRB- TGF-b1 and TGF-b_receptor_II -RRB- as early angiogenic switch indicator in premalignant_lesions_of_the_colon_mucosa .
11263983	0	Endoglin	0,8	TGF-beta1	77,86	Endoglin	TGF-beta1	2022	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Endoglin expression in human and rat mesangial cells and its upregulation by TGF-beta1 .
8655583	0	Endoglin	0,8	TGF-beta_1	41,51	Endoglin	TGF-beta 1	2022	7040	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Endoglin modulates cellular responses to TGF-beta_1 .
16840721	0	Endoglin	0,8	cyclooxygenase-2	19,35	Endoglin	cyclooxygenase-2	13805(Tax:10090)	19225(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Endoglin regulates cyclooxygenase-2 expression and activity .
17376778	0	Endoglin	0,8	transforming_growth_factor-beta1	47,79	Endoglin	transforming growth factor-beta1	2022	7040	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|signaling signaling|amod|END_ENTITY	Endoglin differentially modulates antagonistic transforming_growth_factor-beta1 and BMP-7 signaling .
12889478	0	Endoglycan	0,10	CD34	28,32	Endoglycan	CD34	50512	947	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Endoglycan , a member of the CD34 family , functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x .
18606703	0	Endoglycan	0,10	CD34	28,32	Endoglycan	CD34	50512	947	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Endoglycan , a member of the CD34 family of sialomucins , is a ligand for the vascular selectins .
15985216	0	Endostatin	0,10	bFGF	25,29	Endostatin	bFGF	80781	2247	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans .
15995169	0	Endostatin	0,10	biglycan	17,25	Endostatin	biglycan	12822(Tax:10090)	12111(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial_matrix during atherosclerosis .
17505265	0	Endostatin	0,10	interferon-alpha2b	16,34	Endostatin	interferon-alpha2b	80781	3440	Gene	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Endostatin plus interferon-alpha2b therapy for metastatic_melanoma : a novel combination of antiangiogenic and immunomodulatory agents .
15876483	0	Endostatin	0,10	vascular_endothelial_growth_factor	64,98	Endostatin	vascular endothelial growth factor	12822(Tax:10090)	22339(Tax:10090)	Gene	Gene	transfer|compound|START_ENTITY induces|nsubj|transfer induces|dobj|secretion secretion|compound|END_ENTITY	Endostatin gene transfer in murine lung_carcinoma cells induces vascular_endothelial_growth_factor secretion resulting in up-regulation of in vivo tumorigenecity .
16410224	0	Endostatin	0,10	vascular_endothelial_growth_factor	115,149	Endostatin	vascular endothelial growth factor	80781	7422	Gene	Gene	down-regulates|dep|START_ENTITY down-regulates|nsubj|cyclase cyclase|nmod|cells cells|dep|influence influence|nmod|endostatin endostatin|nmod|END_ENTITY	Endostatin down-regulates soluble guanylate cyclase -LRB- sGC -RRB- in endothelial cells in vivo : influence of endostatin on vascular_endothelial_growth_factor -LRB- VEGF -RRB- signaling .
1709677	0	Endothelial-leukocyte_adhesion_molecule_1	0,41	CR3	97,100	Endothelial-leukocyte adhesion molecule 1	CR3	6401	6998	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	Endothelial-leukocyte_adhesion_molecule_1 stimulates the adhesive activity of leukocyte integrin CR3 -LRB- CD11b/CD18 , Mac-1 , _ alpha_m_beta_2 -RRB- on human neutrophils .
26927690	0	Endothelial_Cell-Specific_Molecule_1	18,54	Endocan	56,63	Endothelial Cell-Specific Molecule 1	Endocan	11082	11082	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	Analysis of Serum Endothelial_Cell-Specific_Molecule_1 -LRB- Endocan -RRB- Level in Type_2_Diabetes_Mellitus With Acute ST-Segment Elevation Myocardial_Infarction and its Correlation : A Pilot Study .
25250890	0	Endothelial_Lipase	27,45	Angiotensin_II	0,14	Endothelial Lipase	Angiotensin II	9388	183	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25742014	0	Endothelial_Lipase	39,57	Angiotensin_II	12,26	Endothelial Lipase	Angiotensin II	9388	183	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Correction : Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25250890	0	Endothelial_Lipase	27,45	NF-Kappa_B	65,75	Endothelial Lipase	NF-Kappa B	9388	4790	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Signaling Signaling|compound|END_ENTITY	Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25742014	0	Endothelial_Lipase	39,57	NF-Kappa_B	77,87	Endothelial Lipase	NF-Kappa B	9388	4790	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Correction : Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
26293469	0	Endothelial_Nitric_Oxide_Synthase	35,68	Polypyrimidine_Tract-Binding_Protein_1	83,121	Endothelial Nitric Oxide Synthase	Polypyrimidine Tract-Binding Protein 1	4846	5725	Gene	Gene	Expression|compound|START_ENTITY Regulation|nmod|Expression Regulation|nmod|END_ENTITY	Post-Transcriptional Regulation of Endothelial_Nitric_Oxide_Synthase Expression by Polypyrimidine_Tract-Binding_Protein_1 .
22802702	0	Endothelial_Nitric_Oxide_Synthase	62,95	p66shc	13,19	Endothelial Nitric Oxide Synthase	p66shc	4846	20416(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY END_ENTITY|dep|Phosphorylation	Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial_Nitric_Oxide_Synthase in Endothelial Cells .
12099714	0	Endothelial_PAS_domain_protein_1	0,32	adrenomedullin	49,63	Endothelial PAS domain protein 1	adrenomedullin	2034	133	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Endothelial_PAS_domain_protein_1 -LRB- EPAS1 -RRB- induces adrenomedullin gene expression in cardiac myocytes : role of EPAS1 in an inflammatory response in cardiac myocytes .
24452940	0	Endothelial_constitutive_nitric_oxide_synthase	0,46	angiotensin_II_type_1_receptor	79,109	Endothelial constitutive nitric oxide synthase	angiotensin II type 1 receptor	4846	185	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Endothelial_constitutive_nitric_oxide_synthase , angiotensin_converting_enzyme , angiotensin_II_type_1_receptor gene polymorphisms and endothelial functions in healthy individuals .
24452940	0	Endothelial_constitutive_nitric_oxide_synthase	0,46	angiotensin_converting_enzyme	48,77	Endothelial constitutive nitric oxide synthase	angiotensin converting enzyme	4846	1636	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Endothelial_constitutive_nitric_oxide_synthase , angiotensin_converting_enzyme , angiotensin_II_type_1_receptor gene polymorphisms and endothelial functions in healthy individuals .
19362550	0	Endothelial_monocyte_activating_polypeptide-II	0,46	hypoxia-inducible_factor-1alpha	97,128	Endothelial monocyte activating polypeptide-II	hypoxia-inducible factor-1alpha	9255	3091	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Endothelial_monocyte_activating_polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible_factor-1alpha through interaction with PSMA7 , a component of the proteasome .
11527006	0	Endothelial_monocyte_activating_polypeptide_II	0,46	TNF	80,83	Endothelial monocyte activating polypeptide II	TNF	9255	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Endothelial_monocyte_activating_polypeptide_II -LRB- EMAP_II -RRB- enhances the effect of TNF on tumor-associated_vasculature .
12506117	0	Endothelial_nitric-oxide_synthase	0,33	tumor_necrosis_factor-alpha	73,100	Endothelial nitric-oxide synthase	tumor necrosis factor-alpha	18127(Tax:10090)	21926(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Endothelial_nitric-oxide_synthase enhances lipopolysaccharide-stimulated tumor_necrosis_factor-alpha expression via cAMP-mediated p38_MAPK pathway in cardiomyocytes .
15755735	0	Endothelial_nitric-oxide_synthase_antisense	0,43	NOS3AS	45,51	Endothelial nitric-oxide synthase antisense	NOS3AS	285973	285973	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Endothelial_nitric-oxide_synthase_antisense -LRB- NOS3AS -RRB- gene encodes an autophagy-related protein -LRB- APG9-like2 -RRB- highly expressed in trophoblast .
18814847	0	Endothelin-1	0,12	ARF6	79,83	Endothelin-1	ARF6	1906	382	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity .
19748488	0	Endothelin-1	0,12	C-reactive_protein	39,57	Endothelin-1	C-reactive protein	24323(Tax:10116)	25419(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Endothelin-1 induces the expression of C-reactive_protein in rat vascular smooth muscle cells .
16985264	0	Endothelin-1	0,12	CD36	23,27	Endothelin-1	CD36	1906	948	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Endothelin-1 decreases CD36 protein expression in vascular smooth muscle cells .
15946919	0	Endothelin-1	0,12	CD40	21,25	Endothelin-1	CD40	1906	958	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Endothelin-1 induces CD40 but not IL-6 in human monocytes via the proinflammatory transcription factor NF-kappaB .
17507309	0	Endothelin-1	0,12	CD40	41,45	Endothelin-1	CD40	1906	958	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|compound|END_ENTITY	Endothelin-1 induces functionally active CD40 protein via nuclear factor-kappaB in human vascular smooth muscle cells .
12388423	0	Endothelin-1	0,12	ERK1/2	38,44	Endothelin-1	ERK1/2	24323(Tax:10116)	50689;116590	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Endothelin-1 activates mesangial cell ERK1/2 via EGF-receptor transactivation and caveolin-1 interaction .
20725141	0	Endothelin-1	0,12	ERK1/2	89,95	Endothelin-1	ERK1/2	1906	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|xcomp|kinase kinase|nsubj|MAP MAP|compound|END_ENTITY	Endothelin-1 induces pulmonary but not aortic smooth_muscle_cell migration by activating ERK1/2 MAP kinase .
26501871	0	Endothelin-1	30,42	ERK1/2	108,114	Endothelin-1	ERK1/2	58032(Tax:7955)	399480;360144	Gene	Gene	Receptor|nmod|START_ENTITY Activation|nmod|Receptor Induces|nsubj|Activation Induces|dobj|Migration Migration|nmod|END_ENTITY	Activation of ETA Receptor by Endothelin-1 Induces Hepatocellular_Carcinoma Cell Migration and Invasion via ERK1/2 and AKT Signaling Pathways .
26226834	0	Endothelin-1	0,12	High_Mobility_Group_Box_1	43,68	Endothelin-1	High Mobility Group Box 1	1906	3146	Gene	Gene	Upregulates|nsubj|START_ENTITY Upregulates|dobj|Expression Expression|nmod|END_ENTITY	Endothelin-1 Upregulates the Expression of High_Mobility_Group_Box_1 in Human Bronchial Epithelial Cells .
16786172	0	Endothelin-1	0,12	Homer_1alpha	23,35	Endothelin-1	Homer 1alpha	1906	9456	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 activates Homer_1alpha expression via mitogen-activated protein kinase in cardiac myocytes .
18472935	0	Endothelin-1	0,12	Interleukin-8	89,102	Endothelin-1	Interleukin-8	1906	3576	Gene	Gene	Stimulates|compound|START_ENTITY Monocytes|nsubj|Stimulates Monocytes|advcl|vitro vitro|nmod|Identified Identified|nmod|END_ENTITY	Endothelin-1 Stimulates Monocytes in vitro to Release Chemotactic Activity Identified as Interleukin-8 and Monocyte_Chemotactic_Protein-1 .
16290054	0	Endothelin-1	0,12	JAK2	27,31	Endothelin-1	JAK2	24323(Tax:10116)	24514(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
15610525	0	Endothelin-1	0,12	MCAM	25,29	Endothelin-1	MCAM	1906	4162	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Endothelin-1 upregulates MCAM in melanocytes .
16417466	0	Endothelin-1	0,12	MMP-2	29,34	Endothelin-1	MMP-2	1906	4313	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|induction induction|amod|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma .
10826501	0	Endothelin-1	0,12	NF-kappaB	86,95	Endothelin-1	NF-kappaB	1906	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|activation activation|nmod|END_ENTITY	Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-kappaB in human vascular smooth muscle cells .
16417466	0	Endothelin-1	0,12	NF-kappaB	90,99	Endothelin-1	NF-kappaB	1906	4790	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|induction induction|nmod|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma .
17460393	0	Endothelin-1	0,12	NF-kappaB	21,30	Endothelin-1	NF-kappaB	1906	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Endothelin-1 induces NF-kappaB via two independent pathways in human renal tubular epithelial cells .
20338996	0	Endothelin-1	0,12	Nedd4-2	72,79	Endothelin-1	Nedd4-2	1906	23327	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Endothelin-1 inhibits the epithelial Na + channel through betaPix/14 -3 -3 / Nedd4-2 .
22209746	0	Endothelin-1	0,12	RIP140	50,56	Endothelin-1	RIP140	13614(Tax:10090)	268903(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|nmod|END_ENTITY	Endothelin-1 promotes cytoplasmic accumulation of RIP140 through a ET -LRB- A -RRB- - PLCb-PKC pathway .
26460070	0	Endothelin-1	111,123	SKA2	97,101	Endothelin-1	SKA2	13614(Tax:10090)	66140(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Peroxisome Proliferator alpha mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulate Endothelin-1 and PAI-1 expression in sickle_cell_disease .
14517226	0	Endothelin-1	0,12	VCAM-1	33,39	Endothelin-1	VCAM-1	24323(Tax:10116)	25361(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Endothelin-1 stimulates arterial VCAM-1 expression via NADPH oxidase-derived superoxide in mineralocorticoid hypertension .
22627111	0	Endothelin-1	0,12	VCAM-1	37,43	Endothelin-1	VCAM-1	24323(Tax:10116)	25361(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral_sphingomyelinase .
26071554	0	Endothelin-1	0,12	VCAM-1	21,27	Endothelin-1	VCAM-1	1906	7412	Gene	Gene	Inflammation|compound|START_ENTITY Inflammation|compound|END_ENTITY	Endothelin-1 Induces VCAM-1 Expression-Mediated Inflammation via Receptor Tyrosine Kinases and Elk/p300 in Human Tracheal Smooth Muscle Cells .
16682005	0	Endothelin-1	0,12	adiponectin	22,33	Endothelin-1	adiponectin	1906	9370	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol_4 ,5 - bisphosphate/actin-dependent mechanism .
17194742	0	Endothelin-1	0,12	adiponectin	23,34	Endothelin-1	adiponectin	1906	9370	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 regulates adiponectin gene expression and secretion in 3T3-L1 adipocytes via distinct signaling pathways .
18623111	0	Endothelin-1	0,12	androgen_receptor	44,61	Endothelin-1	androgen receptor	1906	367	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Endothelin-1 enhances the expression of the androgen_receptor via activation of the c-myc pathway in prostate_cancer cells .
23751363	0	Endothelin-1	0,12	angiotensin-converting_enzyme-2	27,58	Endothelin-1	angiotensin-converting enzyme-2	1906	59272	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 downregulates angiotensin-converting_enzyme-2 expression in human bronchial epithelial cells .
1516947	0	Endothelin-1	0,12	angiotensin_II	42,56	Endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	augments|nsubj|START_ENTITY augments|nmod|infusion infusion|amod|END_ENTITY	Endothelin-1 augments pressor response to angiotensin_II infusion in rats .
19139972	0	Endothelin-1	0,12	angiotensin_II	23,37	Endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Endothelin-1 modulates angiotensin_II in the development of hypertension in fructose-fed rats .
24041954	0	Endothelin-1	0,12	angiotensin_II	77,91	Endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|autoantibody-enhanced autoantibody-enhanced|nsubj|mechanisms mechanisms|nmod|receptor receptor|amod|END_ENTITY	Endothelin-1 , oxidative stress , and endogenous angiotensin_II : mechanisms of angiotensin_II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy .
9595499	0	Endothelin-1	0,12	angiotensin_II	81,95	Endothelin-1	angiotensin II	13614(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|hearts hearts|nmod|END_ENTITY	Endothelin-1 expression in hearts of transgenic_hypertensive_mice overexpressing angiotensin_II .
20587945	0	Endothelin-1	0,12	bone_sialoprotein	27,44	Endothelin-1	bone sialoprotein	24323(Tax:10116)	24477(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Endothelin-1 regulates rat bone_sialoprotein gene transcription .
10503767	0	Endothelin-1	0,12	c-fos	24,29	Endothelin-1	c-fos	1906	2353	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 stimulates c-fos mRNA expression in C6_glioma cells via MAP kinase pathway .
1314585	0	Endothelin-1	0,12	c-fos	24,29	Endothelin-1	c-fos	24323(Tax:10116)	314322(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 stimulates c-fos mRNA expression and acts as a modulator on cell proliferation of rat FRTL5 thyroid cells .
25016214	0	Endothelin-1	0,12	c-fos	79,84	Endothelin-1	c-fos	1906	2353	Gene	Gene	driven|advmod|START_ENTITY proliferation|amod|driven dependent|nsubj|proliferation dependent|advmod|END_ENTITY	Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent .
19111553	0	Endothelin-1	0,12	connective_tissue_growth_factor	21,52	Endothelin-1	connective tissue growth factor	1906	1490	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Endothelin-1 induces connective_tissue_growth_factor expression in cardiomyocytes .
24486572	0	Endothelin-1	0,12	connective_tissue_growth_factor	21,52	Endothelin-1	connective tissue growth factor	1906	1490	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Endothelin-1 induces connective_tissue_growth_factor expression in human lung fibroblasts by ETAR-dependent JNK/AP -1 pathway .
23619396	0	Endothelin-1	0,12	cyclin_D1	24,33	Endothelin-1	cyclin D1	24323(Tax:10116)	58919(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 stimulates cyclin_D1 expression in rat cultured astrocytes via activation of Sp1 .
11423565	0	Endothelin-1	0,12	cyclooxygenase-2	21,37	Endothelin-1	cyclooxygenase-2	24323(Tax:10116)	29527(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells .
15838264	0	Endothelin-1	0,12	cyclooxygenase-2	24,40	Endothelin-1	cyclooxygenase-2	1906	5743	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian_cancer cells through multiple signaling pathways : evidence for involvement of transactivation of the epidermal_growth_factor_receptor .
15838313	0	Endothelin-1	0,12	cyclooxygenase-2	21,37	Endothelin-1	cyclooxygenase-2	24323(Tax:10116)	29527(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells .
18191873	0	Endothelin-1	0,12	cyclooxygenase-2	37,53	Endothelin-1	cyclooxygenase-2	1906	5743	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells .
20452970	0	Endothelin-1	0,12	cyclooxygenase-2	171,187	Endothelin-1	cyclooxygenase-2	1906	5743	Gene	Gene	increases|nsubj|START_ENTITY increases|parataxis|prostacyclin prostacyclin|nsubj|role role|nmod|A A|dep|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways : role of a phospholipase A -LRB- 2 -RRB- -LRB- cPLA -LRB- 2 -RRB- -RRB- / cyclooxygenase-2 -LRB- COX-2 -RRB- / prostacyclin receptor-dependent autocrine loop .
7731170	0	Endothelin-1	0,12	cyclooxygenase-2	26,42	Endothelin-1	cyclooxygenase-2	24323(Tax:10116)	29527(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells .
8135848	0	Endothelin-1	0,12	cytosolic_phospholipase_A2	24,50	Endothelin-1	cytosolic phospholipase A2	100768493	100750927	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Endothelin-1 stimulates cytosolic_phospholipase_A2 in Chinese_hamster ovary cells stably expressing the human ETA_or_ETB_receptor subtype .
10564099	0	Endothelin-1	0,12	endothelial_nitric_oxide_synthase	28,61	Endothelin-1	endothelial nitric oxide synthase	24323(Tax:10116)	24600(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Endothelin-1 stimulation of endothelial_nitric_oxide_synthase in the pathogenesis of hepatopulmonary_syndrome .
9462522	0	Endothelin-1	0,12	endothelin-converting_enzyme-1	22,52	Endothelin-1	endothelin-converting enzyme-1	24323(Tax:10116)	94204(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Endothelin-1 inhibits endothelin-converting_enzyme-1 expression in cultured rat pulmonary endothelial cells .
19111903	0	Endothelin-1	0,12	endothelin_B_receptor	66,87	Endothelin-1	endothelin B receptor	24323(Tax:10116)	50672(Tax:10116)	Gene	Gene	exposure|amod|START_ENTITY alters|nsubj|exposure alters|dobj|expression expression|nmod|END_ENTITY	Endothelin-1 exposure on postnatal day 7 alters expression of the endothelin_B_receptor and behavioral sensitivity to endothelin-1 on postnatal day 11 .
24731444	0	Endothelin-1	0,12	endothelin_B_receptor	31,52	Endothelin-1	endothelin B receptor	24323(Tax:10116)	50672(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Endothelin-1 activation of the endothelin_B_receptor modulates pulmonary endothelial CX3CL1 and contributes to pulmonary angiogenesis in experimental_hepatopulmonary_syndrome .
8606524	0	Endothelin-1	0,12	erythropoietin	24,38	Endothelin-1	erythropoietin	1906	2056	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Endothelin-1 release by erythropoietin involves calcium signaling in endothelial cells .
12684049	0	Endothelin-1	0,12	glial_cell_line-derived_neurotrophic_factor	24,67	Endothelin-1	glial cell line-derived neurotrophic factor	24323(Tax:10116)	25453(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 stimulates glial_cell_line-derived_neurotrophic_factor expression in cultured rat astrocytes .
18249093	0	Endothelin-1	0,12	glut1	21,26	Endothelin-1	glut1	1906	6513	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	Endothelin-1 induces glut1 transcription through enhanced interaction between Sp1 and NF-kappaB transcription factors .
12839867	0	Endothelin-1	0,12	iNOS	40,44	Endothelin-1	iNOS	1906	4843	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Endothelin-1 inhibits TNF_alpha-induced iNOS expression in 3T3-F442A adipocytes .
10331419	0	Endothelin-1	0,12	insulin	23,30	Endothelin-1	insulin	1906	3630	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells .
9746115	0	Endothelin-1	0,12	insulin	38,45	Endothelin-1	insulin	1906	3630	Gene	Gene	infusion|amod|START_ENTITY inhibits|nsubj|infusion inhibits|dobj|responsiveness responsiveness|compound|END_ENTITY	Endothelin-1 infusion inhibits plasma insulin responsiveness in normal men .
24581851	0	Endothelin-1	0,12	interleukin-18	21,35	Endothelin-1	interleukin-18	1906	3606	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Endothelin-1 induces interleukin-18 expression in human osteoblasts .
10452539	0	Endothelin-1	0,12	interleukin-6	59,72	Endothelin-1	interleukin-6	24323(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|family family|amod|END_ENTITY	Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes .
10826501	0	Endothelin-1	0,12	interleukin-6	21,34	Endothelin-1	interleukin-6	1906	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-kappaB in human vascular smooth muscle cells .
19162127	0	Endothelin-1	0,12	interleukin-6	24,37	Endothelin-1	interleukin-6	13614(Tax:10090)	16193(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Endothelin-1 stimulates interleukin-6 secretion from 3T3-L1 adipocytes .
8889860	0	Endothelin-1	0,12	interleukin-6	14,27	Endothelin-1	interleukin-6	1906	3569	Gene	Gene	increase|advmod|START_ENTITY increase|nsubj|levels levels|amod|END_ENTITY	Endothelin-1 , interleukin-6 , and interleukin-8 levels increase in patients with burns .
9787140	0	Endothelin-1	0,12	interleukin-8	69,82	Endothelin-1	interleukin-8	1906	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Endothelin-1 induces production of the neutrophil chemotactic factor interleukin-8 by human brain-derived endothelial cells .
25237831	0	Endothelin-1	55,67	miR-1	49,54	Endothelin-1	miR-1	1906	79187	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	EZH2 promotes angiogenesis through inhibition of miR-1 / Endothelin-1 axis in nasopharyngeal_carcinoma .
25389292	0	Endothelin-1	92,104	miR-199a2	71,80	Endothelin-1	miR-199a2	13614(Tax:10090)	723821(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|amod|END_ENTITY	Peroxisome Proliferator-activated Receptor-a-mediated Transcription of miR-199a2 Attenuates Endothelin-1 Expression via Hypoxia-inducible Factor-1a .
15347558	0	Endothelin-1	0,12	mucin	22,27	Endothelin-1	mucin	1906	100508689	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Endothelin-1 inhibits mucin secretion from ovine airway epithelial goblet cells .
22627111	0	Endothelin-1	0,12	neutral_sphingomyelinase	81,105	Endothelin-1	neutral sphingomyelinase	24323(Tax:10116)	83537(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral_sphingomyelinase .
16005303	0	Endothelin-1	0,12	norepinephrine_transporter	35,61	Endothelin-1	norepinephrine transporter	24323(Tax:10116)	83511(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Endothelin-1 inhibits the neuronal norepinephrine_transporter in hearts of male rats .
23279852	0	Endothelin-1	0,12	p53	44,47	Endothelin-1	p53	13614(Tax:10090)	22060(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis .
16878432	0	Endothelin-1	0,12	parathyroid_hormone	23,42	Endothelin-1	parathyroid hormone	1906	5741	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 regulates parathyroid_hormone expression of human parathyroid cells .
1809396	0	Endothelin-1	0,12	protein_kinase_C_beta_1	97,120	Endothelin-1	protein kinase C beta 1	24323(Tax:10116)	25023(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Endothelin-1 activates phospholipase_D and thymidine incorporation in fibroblasts overexpressing protein_kinase_C_beta_1 .
11719468	0	Endothelin-1	0,12	proteinase	27,37	Endothelin-1	proteinase	1906	100616101	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	Endothelin-1 induces tumor proteinase activation and invasiveness_of_ovarian_carcinoma cells .
24424064	0	Endothelin-1	0,12	resistin	24,32	Endothelin-1	resistin	1906	56729	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 stimulates resistin gene expression .
7503720	0	Endothelin-1	0,12	thrombin	67,75	Endothelin-1	thrombin	1906	2147	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|internalization internalization|nmod|receptor receptor|compound|END_ENTITY	Endothelin-1 induces rapid and long lasting internalization of the thrombin receptor in human glomerular epithelial cells .
10206185	0	Endothelin-1	0,12	vascular_cell_adhesion_molecule-1	22,55	Endothelin-1	vascular cell adhesion molecule-1	1906	7412	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Endothelin-1 enhances vascular_cell_adhesion_molecule-1 expression in tumor_necrosis_factor_alpha-stimulated vascular endothelial cells .
10889466	0	Endothelin-1	0,12	vascular_endothelial_growth_factor	21,55	Endothelin-1	vascular endothelial growth factor	13614(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|compound|END_ENTITY	Endothelin-1 induces vascular_endothelial_growth_factor synthesis in osteoblasts : involvement of p38 mitogen-activated protein kinase .
12023962	0	Endothelin-1	0,12	vascular_endothelial_growth_factor	21,55	Endothelin-1	vascular endothelial growth factor	1906	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Endothelin-1 induces vascular_endothelial_growth_factor by increasing hypoxia-inducible_factor-1alpha in ovarian_carcinoma cells .
21174590	0	Endothelin-1	0,12	vascular_endothelial_growth_factor	27,61	Endothelin-1	vascular endothelial growth factor	1906	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Endothelin-1 expression by vascular_endothelial_growth_factor in human umbilical vein endothelial cells and aortic smooth muscle cells .
14962807	0	Endothelin-1	0,12	vascular_endothelial_growth_factor-A	46,82	Endothelin-1	vascular endothelial growth factor-A	24323(Tax:10116)	83785(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Endothelin-1 down-regulates the expression of vascular_endothelial_growth_factor-A associated with osteoprogenitor proliferation and differentiation .
1653767	0	Endothelin-3	0,12	endothelin-1	23,35	Endothelin-3	endothelin-1	1908	1906	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Endothelin-3 regulates endothelin-1 production in cultured human endothelial cells .
1899191	0	Endothelin-3	0,12	prolactin	22,31	Endothelin-3	prolactin	366270(Tax:10116)	24683(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Endothelin-3 inhibits prolactin and stimulates LH , FSH and TSH secretion from pituitary cell culture .
8177498	0	Endothelin-3	0,12	voltage-gated_Ca_channel	25,49	Endothelin-3	voltage-gated Ca channel	366270(Tax:10116)	246215(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Endothelin-3 activates a voltage-gated_Ca_channel via a pertussis toxin sensitive mechanism leading to dopamine release from PC12 cells .
19617920	0	Endothelin-Converting_Enzyme-1	56,86	Protein_Kinase_C	0,16	Endothelin-Converting Enzyme-1	Protein Kinase C	1889	112476	Gene	Gene	Activity|nmod|START_ENTITY Regulates|dobj|Activity Regulates|nsubj|END_ENTITY	Protein_Kinase_C Regulates the Cell Surface Activity of Endothelin-Converting_Enzyme-1 .
25268585	0	Endothelin-Converting_Enzyme_1	50,80	Endothelin_1	23,35	Endothelin-Converting Enzyme 1	Endothelin 1	1889	1906	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|compound|END_ENTITY	Substance_P Stimulates Endothelin_1 Secretion via Endothelin-Converting_Enzyme_1 and Promotes Melanogenesis in Human Melanocytes .
25268585	0	Endothelin-Converting_Enzyme_1	50,80	Substance_P	0,11	Endothelin-Converting Enzyme 1	Substance P	1889	6863	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|compound|END_ENTITY	Substance_P Stimulates Endothelin_1 Secretion via Endothelin-Converting_Enzyme_1 and Promotes Melanogenesis in Human Melanocytes .
12824294	0	Endothelin-converting_enzyme-1	0,30	Nkx2-5	99,105	Endothelin-converting enzyme-1	Nkx2-5	1889	1482	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- is a downstream target of the homeobox transcription factor Nkx2-5 .
17574232	0	Endothelin1	53,64	mef2ca	0,6	Endothelin1	mef2ca	58032(Tax:7955)	30575(Tax:7955)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish .
16740995	0	Endothelin_1	0,12	Cdc42	57,62	Endothelin 1	Cdc42	1906	998	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Endothelin_1 stimulates beta1Pix-dependent activation of Cdc42 through the G -LRB- salpha -RRB- pathway .
25268585	0	Endothelin_1	23,35	Endothelin-Converting_Enzyme_1	50,80	Endothelin 1	Endothelin-Converting Enzyme 1	1906	1889	Gene	Gene	Secretion|compound|START_ENTITY Secretion|nmod|END_ENTITY	Substance_P Stimulates Endothelin_1 Secretion via Endothelin-Converting_Enzyme_1 and Promotes Melanogenesis in Human Melanocytes .
25268585	0	Endothelin_1	23,35	Substance_P	0,11	Endothelin 1	Substance P	1906	6863	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Substance_P Stimulates Endothelin_1 Secretion via Endothelin-Converting_Enzyme_1 and Promotes Melanogenesis in Human Melanocytes .
22431579	0	Endothelin_1	0,12	endothelin_A_receptor	27,48	Endothelin 1	endothelin A receptor	24323(Tax:10116)	24326(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Endothelin_1 activation of endothelin_A_receptor / NADPH oxidase pathway and diminished antioxidants critically contribute to endothelial progenitor cell reduction and dysfunction in salt-sensitive hypertension .
21725757	0	Endothelin_receptor-A	0,21	ETa	23,26	Endothelin receptor-A	ETa	24326(Tax:10116)	24326(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Endothelin_receptor-A -LRB- ETa -RRB- inhibition fails to improve neonatal hypoxic-ischemic_brain_injury in rats .
20371740	0	Endothelin_type_A_receptor	0,26	ETA	28,31	Endothelin type A receptor	ETA	1909	1909	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Endothelin_type_A_receptor -LRB- ETA -RRB- expression is regulated by HOXA10 in human endometrial stromal cells .
20371740	0	Endothelin_type_A_receptor	0,26	HOXA10	60,66	Endothelin type A receptor	HOXA10	1909	3206	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Endothelin_type_A_receptor -LRB- ETA -RRB- expression is regulated by HOXA10 in human endometrial stromal cells .
22571958	0	Eng	43,46	VEGF	52,56	Eng	VEGF	13805(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular_dysplasia in the adult mouse .
9342190	0	Engrailed	24,33	En-1	35,39	Engrailed	En-1	771008(Tax:9031)	771008(Tax:9031)	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	The homeobox-containing Engrailed -LRB- En-1 -RRB- product down-regulates the expression of Pax-6 through a DNA binding-independent mechanism .
10069333	0	Engrailed	0,9	connectin	73,82	Engrailed	connectin	36240(Tax:7227)	38590(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Engrailed negatively regulates the expression of cell adhesion molecules connectin and neuroglian_in_embryonic_Drosophila_nervous_system .
23792811	0	Engrailed-2	8,19	EN2	21,24	Engrailed-2	EN2	2020	2020	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Engrailed-2 -LRB- EN2 -RRB- as a prostate_cancer detection biomarker in genetically high risk men .
24654775	0	Engrailed-2	31,42	EN2	44,47	Engrailed-2	EN2	2020	2020	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Spontaneous antibodies against Engrailed-2 -LRB- EN2 -RRB- protein in patients with prostate_cancer .
19359245	0	Enhancer_of_polycomb1	0,21	serum_response_factor	30,51	Enhancer of polycomb1	serum response factor	13831(Tax:10090)	20807(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Enhancer_of_polycomb1 acts on serum_response_factor to regulate skeletal muscle differentiation .
12039038	0	Enhancer_of_zeste	11,28	dSAP18	52,58	Enhancer of zeste	dSAP18	39203(Tax:7227)	41965(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	Drosophila Enhancer_of_zeste protein interacts with dSAP18 .
25917318	0	Enhancer_of_zeste_homolog-2	0,27	interleukin-1b	139,153	Enhancer of zeste homolog-2	interleukin-1b	2146	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Enhancer_of_zeste_homolog-2 -LRB- EZH2 -RRB- methyltransferase regulates transgelin/smooth muscle-22a expression in endothelial cells in response to interleukin-1b and transforming_growth_factor-b2 .
20920340	0	Enhancer_of_zeste_homolog_2	0,27	EZH2	29,33	Enhancer of zeste homolog 2	EZH2	2146	2146	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Enhancer_of_zeste_homolog_2 -LRB- EZH2 -RRB- expression is an independent prognostic factor in renal_cell_carcinoma .
18430739	0	Enhancer_of_zeste_homologue_2	0,29	RUNX3	52,57	Enhancer of zeste homologue 2	RUNX3	2146	864	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Enhancer_of_zeste_homologue_2 -LRB- EZH2 -RRB- down-regulates RUNX3 by increasing histone H3 methylation .
1466765	0	Enkephalin	0,10	cholecystokinin	42,57	Enkephalin	cholecystokinin	29237(Tax:10116)	25298(Tax:10116)	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Enkephalin is a competitive antagonist of cholecystokinin in the gastrointestinal tract , as predicted from prior conformational analysis .
21099228	0	Enpp1	44,49	RAGE	36,40	Enpp1	RAGE	18605(Tax:10090)	11596(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Arterial_calcification is driven by RAGE in Enpp1 - / - mice .
15107463	0	Ent3p	23,28	Ent5p	0,5	Ent3p	Ent5p	853589(Tax:4932)	851731(Tax:4932)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body .
15107463	0	Ent5p	0,5	Ent3p	23,28	Ent5p	Ent3p	851731(Tax:4932)	853589(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Ent5p is required with Ent3p and Vps27p for ubiquitin-dependent protein sorting into the multivesicular body .
27026376	0	Env	28,31	CCR5	0,4	Env	CCR5	155971(Tax:11676)	1234	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	CCR5 interaction with HIV-1 Env contributes to Env-induced depletion of CD4 T cells in vitro and in vivo .
10590121	0	Env	114,117	CD4	100,103	Env	CD4	155971(Tax:11676)	920	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Sequential CD4-coreceptor interactions in human_immunodeficiency_virus_type_1 Env function : soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120 .
19769157	0	Env	35,38	envelope	25,33	Env	envelope	155971(Tax:11676)	155971(Tax:11676)	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	-LSB- The impact of the HIV-1 envelope -LRB- Env -RRB- mutation on its assembly of functional pseudovirus -RSB- .
10446220	0	Enx	47,50	Ncx	42,45	Enx	Ncx	21909(Tax:10090)	3196	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	An enhancer element for expression of the Ncx -LRB- Enx , Hox11L1 -RRB- gene in neural crest-derived cells .
8861097	0	Enx-1	51,56	Polycomb_group	72,86	Enx-1	Polycomb group	14056(Tax:10090)	40358(Tax:7227)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Isolation and developmental expression analysis of Enx-1 , a novel mouse Polycomb_group gene .
9473645	0	Enx-2	67,72	Polycomb_group	40,54	Enx-2	Polycomb group	14055(Tax:10090)	40358(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and expression of a human/mouse Polycomb_group gene , ENX-2 / Enx-2 .
20056084	0	Eomes	40,45	IFN-gamma	49,58	Eomes	IFN-gamma	8320	3458	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	-LSB- Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets -RSB- .
22402664	0	Eomesodermin	0,12	Activin	110,117	Eomesodermin	Activin	8320	83729	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|absence absence|nmod|END_ENTITY	Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin .
21880986	0	Eomesodermin	44,56	CD134	0,5	Eomesodermin	CD134	13813(Tax:10090)	22163(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation .
19224637	0	Eomesodermin	80,92	CD152	0,5	Eomesodermin	CD152	8320	1493	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	CD152 -LRB- CTLA-4 -RRB- regulates effector functions of CD8 + T lymphocytes by repressing Eomesodermin .
14605368	0	Eomesodermin	69,81	CD8	20,23	Eomesodermin	CD8	8320	925	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Control Control|nmod|cell cell|compound|END_ENTITY	Control of effector CD8 + T cell function by the transcription factor Eomesodermin .
19224637	0	Eomesodermin	80,92	CD8	47,50	Eomesodermin	CD8	8320	925	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|dobj|functions functions|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD152 -LRB- CTLA-4 -RRB- regulates effector functions of CD8 + T lymphocytes by repressing Eomesodermin .
22402664	0	Eomesodermin	0,12	Mesp1	21,26	Eomesodermin	Mesp1	8320	55897	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin .
10473127	0	Eomesodermin	32,44	Tbr2	26,30	Eomesodermin	Tbr2	13813(Tax:10090)	13813(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression pattern of the Tbr2 -LRB- Eomesodermin -RRB- gene during mouse and chick brain development .
17587163	0	Eosinophil_cationic_protein	0,27	TGF-beta1	39,48	Eosinophil cationic protein	TGF-beta1	6037	7040	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Eosinophil_cationic_protein stimulates TGF-beta1 release by human lung fibroblasts in vitro .
22702502	0	Eosinophil_peroxidase	0,21	acid-sensing_ion_channel-3	61,87	Eosinophil peroxidase	acid-sensing ion channel-3	8288	9311	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Eosinophil_peroxidase induces the expression and function of acid-sensing_ion_channel-3 in allergic_rhinitis : in vitro evidence in cultured epithelial cells .
8977530	0	Eosinophil_peroxidase	0,21	granulocyte-macrophage_colony-stimulating_factor	48,96	Eosinophil peroxidase	granulocyte-macrophage colony-stimulating factor	8288	1437	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Eosinophil_peroxidase stimulates the release of granulocyte-macrophage_colony-stimulating_factor from bronchial epithelial cells .
7920015	0	Eosinophil_peroxidase	0,21	myeloperoxidase	46,61	Eosinophil peroxidase	myeloperoxidase	8288	4353	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Eosinophil_peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase .
24604010	0	Eotaxin-1	0,9	MMP-3	108,113	Eotaxin-1	MMP-3	6356	4314	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|invasion invasion|nmod|activation activation|nmod|pathway pathway|nmod|expression expression|compound|END_ENTITY	Eotaxin-1 promotes prostate_cancer cell invasion via activation of the CCR3-ERK pathway and upregulation of MMP-3 expression .
15589317	0	Eotaxin-3	63,72	CCL26	73,78	Eotaxin-3	CCL26	10344	10344	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3 / CCL26 gene expression in HEK293 cells .
26418908	0	Eotaxin-3	0,9	CCL26	11,16	Eotaxin-3	CCL26	10344	10344	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Eotaxin-3 -LRB- CCL26 -RRB- Expression in Human Pancreatic Myofibroblasts .
12689946	0	Eotaxin-3	0,9	CCR2	38,42	Eotaxin-3	CCR2	10344	729230	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes .
15589317	0	Eotaxin-3	63,72	IL-4	26,30	Eotaxin-3	IL-4	10344	3565	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression induced|dobj|activation END_ENTITY|acl|induced	SOCS-1 and SOCS-3 inhibit IL-4 and IL-13 induced activation of Eotaxin-3 / CCL26 gene expression in HEK293 cells .
16678891	0	Ep-CAM	53,59	epithelial_cell_adhesion_molecule	18,51	Ep-CAM	epithelial cell adhesion molecule	4072	4072	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of epithelial_cell_adhesion_molecule -LRB- Ep-CAM -RRB- is an independent prognostic marker for reduced survival of patients with epithelial_ovarian_cancer .
8566052	0	Ep-CAM	85,91	gp40	14,18	Ep-CAM	gp40	4072	17075(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of gp40 , the murine homologue of human epithelial_cell_adhesion_molecule -LRB- Ep-CAM -RRB- , by murine dendritic cells .
15922867	0	EpCAM	30,35	E-FABP	79,85	EpCAM	E-FABP	4072	2171	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	The tumour-associated antigen EpCAM upregulates the fatty_acid binding protein E-FABP .
26401964	0	EpCAM	49,54	Epithelial_Cell_Adhesion_Molecule	14,47	EpCAM	Epithelial Cell Adhesion Molecule	4072	4072	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Epithelial_Cell_Adhesion_Molecule -LRB- EpCAM -RRB- in oral_squamous_cell_Carcinoma .
21799003	0	EpCAM	35,40	Epithelial_cell_adhesion_molecule	0,33	EpCAM	Epithelial cell adhesion molecule	17075(Tax:10090)	17075(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Epithelial_cell_adhesion_molecule -LRB- EpCAM -RRB- complex proteins promote transcription factor-mediated pluripotency reprogramming .
26540343	0	EpCAM	74,79	LINC00152	0,9	EpCAM	LINC00152	4072	112597	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	LINC00152 promotes proliferation in hepatocellular_carcinoma by targeting EpCAM via the mTOR signaling pathway .
22974215	0	EpCAM	50,55	MMP7	0,4	EpCAM	MMP7	4072	4316	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MMP7 is a target of the tumour-associated antigen EpCAM .
22547929	0	EpCAM	106,111	T-cell_antigen_receptor	53,76	EpCAM	T-cell antigen receptor	4072	846	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of a fully human chimeric T-cell_antigen_receptor for tumor-associated antigen EpCAM .
25966221	0	EpCAM	14,19	b-catenin	29,38	EpCAM	b-catenin	4072	1499	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of EpCAM and Wnt / b-catenin in human colon_cancer .
15195135	0	EpCAM	33,38	c-myc	51,56	EpCAM	c-myc	4072	4609	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation .
16054130	0	EpCAM	32,37	claudin-7	89,98	EpCAM	claudin-7	171577(Tax:10116)	65132(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7 .
23988446	0	EpCAM	0,5	endoplasmic_reticulum_aminopeptidase_2	22,60	EpCAM	endoplasmic reticulum aminopeptidase 2	481360(Tax:9615)	488897(Tax:9615)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	EpCAM associates with endoplasmic_reticulum_aminopeptidase_2 -LRB- ERAP2 -RRB- in breast_cancer cells .
24906438	0	EpCAM	57,62	epithelial_cell_adhesion_molecule	22,55	EpCAM	epithelial cell adhesion molecule	4072	4072	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	The overexpression of epithelial_cell_adhesion_molecule -LRB- EpCAM -RRB- in glioma .
22517003	0	EpCAM	72,77	epithelial_cellular_adhesion_molecule	33,70	EpCAM	epithelial cellular adhesion molecule	4072	4072	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	-LSB- Detection and clinical value of epithelial_cellular_adhesion_molecule -LRB- EpCAM -RRB- mRNA positive circulating tumor cells in metastatic breast_cancer -RSB- .
22517003	0	EpCAM	72,77	tumor	105,110	EpCAM	EpCAM	4072	4072	Gene	Gene	cells|appos|START_ENTITY cells|compound|END_ENTITY	-LSB- Detection and clinical value of epithelial_cellular_adhesion_molecule -LRB- EpCAM -RRB- mRNA positive circulating tumor cells in metastatic breast_cancer -RSB- .
15613858	0	EpCam	49,54	epithelial_cell_adhesion_molecule	14,47	EpCam	epithelial cell adhesion molecule	4072	4072	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of epithelial_cell_adhesion_molecule -LRB- EpCam -RRB- in renal_epithelial_tumors .
17174312	0	Epac	0,4	ERK1/2	27,33	Epac	ERK1/2	10411	5595;5594	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Epac - and Rap - independent ERK1/2 phosphorylation induced by Gs-coupled receptor stimulation in HEK293 cells .
11375794	0	Epac	25,29	Rap1	31,35	Epac	Rap1	10411	5906	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Mutation analysis of the Epac -- Rap1 signaling pathway in cold thyroid_follicular_adenomas .
12887090	0	Epac	133,137	Rap1	15,19	Epac	Rap1	223864(Tax:10090)	109905(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY activates|parataxis|mediated activates|dobj|END_ENTITY	CAMP activates Rap1 in differentiating mouse male germ cells : a new signaling pathway mediated by the cAMP-activated exchange factor Epac ?
17068197	0	Epac	111,115	Rap1	87,91	Epac	Rap1	10411	5906	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Cyclic_adenosine_5 ' - monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways .
19546222	0	Epac	0,4	Rap1	36,40	Epac	Rap1	10411	27342	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis .
9853756	0	Epac	0,4	Rap1	10,14	Epac	Rap1	10411	5906	Gene	Gene	factor|nsubj|START_ENTITY factor|amod|END_ENTITY	Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic_AMP .
17203972	0	Epac1	109,114	TGFbeta	88,95	Epac1	TGFbeta	10411	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Interactome of transforming_growth_factor-beta type I receptor -LRB- TbetaRI -RRB- : inhibition of TGFbeta signaling by Epac1 .
16115630	0	Epac1	0,5	VE-cadherin	64,75	Epac1	VE-cadherin	10411	1003	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Epac1 regulates integrity of endothelial cell junctions through VE-cadherin .
8786142	0	Epb72	79,84	stomatin	64,72	Epb72	stomatin	13830(Tax:10090)	13830(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and 5 ' - flanking DNA sequence of the murine stomatin gene -LRB- Epb72 -RRB- .
23667256	0	Epcam	30,35	epithelial_cell_adhesion_molecule	37,70	Epcam	epithelial cell adhesion molecule	406454(Tax:7955)	406454(Tax:7955)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Zeb1 regulates E-cadherin and Epcam -LRB- epithelial_cell_adhesion_molecule -RRB- expression to control cell behavior in early zebrafish development .
10648835	0	Eph	40,43	EphB6	54,59	Eph	EphB6	2041	2051	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Ephrin-B2 is a candidate ligand for the Eph receptor , EphB6 .
19118217	0	EphA1	0,5	integrin-linked_kinase	21,43	EphA1	integrin-linked kinase	2041	3611	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	EphA1 interacts with integrin-linked_kinase and regulates cell morphology and motility .
9733765	0	EphA2	27,32	Eck	34,37	EphA2	Eck	13836(Tax:10090)	13836(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	An enhancer element in the EphA2 -LRB- Eck -RRB- gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins .
25239188	0	EphA2	37,42	EphB6	0,5	EphA2	EphB6	1969	2051	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	EphB6 promotes anoikis by modulating EphA2 signaling .
17332925	0	EphA2	71,76	Ephrin-A1	0,9	EphA2	Ephrin-A1	1969	1942	Gene	Gene	down-regulation|nmod|START_ENTITY regulator|nmod|down-regulation regulator|nsubj|END_ENTITY	Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK .
22261062	0	EphA2	0,5	Ephrin-A1	39,48	EphA2	Ephrin-A1	1969	1942	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	EphA2 receptor activation by monomeric Ephrin-A1 on supported membranes .
20571968	0	EphA2	17,22	EphrinA1	46,54	EphA2	EphrinA1	1969	1942	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant_glioma .
24825902	0	EphA2	59,64	Ephrin_A2	48,57	EphA2	Ephrin A2	1943	1943	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Binding and function of phosphotyrosines of the Ephrin_A2 -LRB- EphA2 -RRB- receptor using synthetic sterile a motif -LRB- SAM -RRB- domains .
18079969	0	EphA2	29,34	ErbB2	130,135	EphA2	ErbB2	13836(Tax:10090)	13866(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma_tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling .
23629968	0	EphA2	0,5	MT1-MMP	18,25	EphA2	MT1-MMP	1969	4323	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion .
26191168	0	EphA2	99,104	MiR-26b	0,7	EphA2	MiR-26b	1969	407017	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MiR-26b inhibits hepatocellular_carcinoma cell proliferation , migration , and invasion by targeting EphA2 .
17135240	0	EphA2	14,19	SHIP2	44,49	EphA2	SHIP2	1969	3636	Gene	Gene	receptor|amod|START_ENTITY Regulation|nmod|receptor endocytosis|nsubj|Regulation endocytosis|nmod|phosphatase phosphatase|compound|END_ENTITY	Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation .
22244754	0	EphA2	87,92	SHIP2	134,139	EphA2	SHIP2	1969	3636	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	NMR structure of a heterodimeric SAM : SAM complex : characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2 .
24112471	0	EphA2	0,5	Tiam1	47,52	EphA2	Tiam1	1969	7074	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	EphA2 signaling following endocytosis : role of Tiam1 .
16481735	0	EphA2	22,27	VE-cadherin	0,11	EphA2	VE-cadherin	1969	1003	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway : implications for vasculogenic mimicry .
11146556	0	EphA2	39,44	ephrin-A1	4,13	EphA2	ephrin-A1	1969	1942	Gene	Gene	ligand|appos|START_ENTITY ligand|amod|END_ENTITY	The ephrin-A1 ligand and its receptor , EphA2 , are expressed during tumor neovascularization .
22173506	0	EphA2	20,25	ephrin-A1	10,19	EphA2	ephrin-A1	1969	1942	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of ephrin-A1 / EphA2 on invasion of trophoblastic cells .
23661698	0	EphA2	97,102	ephrin-A1	63,72	EphA2	ephrin-A1	1969	1942	Gene	Gene	tyrosine|amod|START_ENTITY ligand|nmod|tyrosine kinase|amod|ligand characterization|appos|kinase characterization|nmod|glycosylation glycosylation|nmod|END_ENTITY	Biological and structural characterization of glycosylation on ephrin-A1 , a preferred ligand for EphA2 receptor tyrosine kinase .
22184117	0	EphA2	29,34	hypermethylated_in_cancer_1	62,89	EphA2	hypermethylated in cancer 1	1969	3090	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated_in_cancer_1 -LRB- HIC1 -RRB- .
24647573	0	EphA2	95,100	miR-141	0,7	EphA2	miR-141	1969	406933	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	miR-141 is a key regulator of renal_cell_carcinoma proliferation and metastasis by controlling EphA2 expression .
21264258	0	EphA2	74,79	microRNA-26b	8,20	EphA2	microRNA-26b	1969	407017	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of microRNA-26b in glioma development and its mediated regulation on EphA2 .
14697337	0	EphA3	0,5	CD28	20,24	EphA3	CD28	2042	940	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion .
25231727	0	EphA3	0,5	PrLZ	23,27	EphA3	PrLZ	2042	7163	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	EphA3 , induced by PC-1 / PrLZ , contributes to the malignant progression of prostate_cancer .
25676701	0	EphA4	117,122	Osteoclastic_Transmembrane_Protein-Tyrosine_Phosphatase	3,58	EphA4	Osteoclastic Transmembrane Protein-Tyrosine Phosphatase	2043	5800	Gene	Gene	Activity|nmod|START_ENTITY Activity|amod|END_ENTITY	An Osteoclastic_Transmembrane_Protein-Tyrosine_Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts .
12617855	0	EphA4	70,75	Pax_2	0,5	EphA4	Pax 2	395559(Tax:9031)	395574(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Pax_2 expression in mesodermal segmentation and its relationship with EphA4 and Lunatic-fringe during chicken somitogenesis .
14516678	0	EphA4	70,75	Pax_2	0,5	EphA4	Pax 2	395559(Tax:9031)	395574(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Pax_2 expression in mesodermal segmentation and its relationship with EphA4 and Lunatic-fringe during chicken somitogenesis .
9789074	0	EphA4	0,5	Sek1	7,11	EphA4	Sek1	13838(Tax:10090)	13838(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	EphA4 -LRB- Sek1 -RRB- receptor tyrosine kinase is required for the development of the corticospinal tract .
24658113	0	EphA4	0,5	c-Abl	20,25	EphA4	c-Abl	2043	25	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-b oligomers .
17304517	0	EphA6	26,31	HOXA13	0,6	EphA6	HOXA13	13840(Tax:10090)	15398(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HOXA13 directly regulates EphA6 and EphA7 expression in the genital_tubercle vascular endothelia .
15663472	0	EphB1	114,119	ephrinB2	128,136	EphB1	ephrinB2	270190(Tax:10090)	13642(Tax:10090)	Gene	Gene	ligand|amod|START_ENTITY ligand|appos|END_ENTITY	Nurr1 co-localizes with EphB1 receptors in the developing ventral midbrain , and its expression is enhanced by the EphB1 ligand , ephrinB2 .
25120806	0	EphB1	52,57	receptor_tyrosine_kinase	24,48	EphB1	receptor tyrosine kinase	2047	5979	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein expression|nmod|END_ENTITY	Decreased expression of receptor_tyrosine_kinase of EphB1 protein in renal_cell_carcinomas .
11956217	0	EphB2	72,77	RYK	0,3	EphB2	RYK	2048	6259	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	RYK , a catalytically inactive receptor tyrosine kinase , associates with EphB2 and EphB3 but does not interact with AF-6 .
18092944	0	EphB2	62,67	ephrin-B1	27,36	EphB2	ephrin-B1	2048	1947	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and function of ephrin-B1 and its cognate receptor EphB2 in human atherosclerosis : from an aspect of chemotaxis .
9484836	0	EphB3	37,42	Ephrin-B3	0,9	EphB3	Ephrin-B3	13845(Tax:10090)	13643(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Ephrin-B3 , a ligand for the receptor EphB3 , expressed at the midline of the developing neural tube .
24677183	0	EphB4	10,15	Ephrin_B2	0,9	EphB4	Ephrin B2	13846(Tax:10090)	13642(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Ephrin_B2 / EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation .
24677183	0	EphB4	10,15	IGF-I	40,45	EphB4	IGF-I	13846(Tax:10090)	16000(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|actions actions|nmod|END_ENTITY	Ephrin_B2 / EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation .
23394931	0	EphB4	46,51	Vascular_endothelial_growth_factor-A	0,36	EphB4	Vascular endothelial growth factor-A	2050	7422	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Vascular_endothelial_growth_factor-A inhibits EphB4 and stimulates delta-like_ligand_4 expression in adult endothelial cells .
12734395	0	EphB4	8,13	ephrinB2	94,102	EphB4	ephrinB2	2050	1948	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|cells cells|amod|END_ENTITY	Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells .
10648835	0	EphB6	54,59	Eph	40,43	EphB6	Eph	2051	2041	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Ephrin-B2 is a candidate ligand for the Eph receptor , EphB6 .
25239188	0	EphB6	0,5	EphA2	37,42	EphB6	EphA2	2051	1969	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	EphB6 promotes anoikis by modulating EphA2 signaling .
23725356	0	Eph_receptor_B4	0,15	estrogen_receptor_alpha	34,57	Eph receptor B4	estrogen receptor alpha	2050	2099	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Eph_receptor_B4 is a regulator of estrogen_receptor_alpha in breast_cancer cells .
21621533	0	Ephexin4	0,8	RhoG	57,61	Ephexin4	RhoG	27237	391	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol_3-kinase .
26833123	0	Ephrin-A1	4,13	EPHA2	14,19	Ephrin-A1	EPHA2	1942	1969	Gene	Gene	START_ENTITY|dep|Metabolism Metabolism|compound|END_ENTITY	The Ephrin-A1 / EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast_Cancer .
17332925	0	Ephrin-A1	0,9	EphA2	71,76	Ephrin-A1	EphA2	1942	1969	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|down-regulation down-regulation|nmod|END_ENTITY	Ephrin-A1 is a negative regulator in glioma through down-regulation of EphA2 and FAK .
22261062	0	Ephrin-A1	39,48	EphA2	0,5	Ephrin-A1	EphA2	1942	1969	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	EphA2 receptor activation by monomeric Ephrin-A1 on supported membranes .
24103748	0	Ephrin-A1	0,9	S100A8	32,38	Ephrin-A1	S100A8	1942	6279	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Ephrin-A1 expression induced by S100A8 is mediated by the toll-like_receptor_4 .
12794130	0	Ephrin-A1	0,9	c-Cbl	18,23	Ephrin-A1	c-Cbl	1942	867	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells .
24103748	0	Ephrin-A1	0,9	toll-like_receptor_4	58,78	Ephrin-A1	toll-like receptor 4	1942	7099	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|nmod|END_ENTITY	Ephrin-A1 expression induced by S100A8 is mediated by the toll-like_receptor_4 .
11870224	0	Ephrin-A5	0,9	CrkII	100,105	Ephrin-A5	CrkII	1946	1398	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Ephrin-A5 induces rounding , blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling .
20445540	0	Ephrin-B2	0,9	VEGFR2	20,26	Ephrin-B2	VEGFR2	13642(Tax:10090)	16542(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nummod|END_ENTITY	Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis .
9484836	0	Ephrin-B3	0,9	EphB3	37,42	Ephrin-B3	EphB3	13643(Tax:10090)	13845(Tax:10090)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Ephrin-B3 , a ligand for the receptor EphB3 , expressed at the midline of the developing neural tube .
26505562	0	Ephrin-B3	0,9	PSD-95	19,25	Ephrin-B3	PSD-95	1949	1742	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|END_ENTITY	Ephrin-B3 recruits PSD-95 to synapses .
20571968	0	EphrinA1	46,54	EphA2	17,22	EphrinA1	EphA2	1942	1969	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant_glioma .
24825906	0	EphrinB1	0,8	CNK1	24,28	EphrinB1	CNK1	1947	10256	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation .
22622516	0	EphrinB2	13,21	BMP9	0,4	EphrinB2	BMP9	13642(Tax:10090)	12165(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID 1/ID3-dependent pathway : implications for hereditary_hemorrhagic_telangiectasia_type_II .
18694808	0	EphrinB2	0,8	NR2B	45,49	EphrinB2	NR2B	306636(Tax:10116)	24410(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia .
21147838	0	EphrinB2	0,8	NR2B	105,109	EphrinB2	NR2B	306636(Tax:10116)	24410(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|potentiation potentiation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	EphrinB2 induces pelvic-urethra reflex potentiation via Src kinase-dependent tyrosine phosphorylation of NR2B .
18627264	0	EphrinB2	0,8	PTH	23,26	EphrinB2	PTH	13642(Tax:10090)	19226(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts .
24825902	0	Ephrin_A2	48,57	EphA2	59,64	Ephrin A2	EphA2	1943	1943	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Binding and function of phosphotyrosines of the Ephrin_A2 -LRB- EphA2 -RRB- receptor using synthetic sterile a motif -LRB- SAM -RRB- domains .
24677183	0	Ephrin_B2	0,9	EphB4	10,15	Ephrin B2	EphB4	13642(Tax:10090)	13846(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Ephrin_B2 / EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation .
25799492	0	Epidermal_Growth_Factor	118,141	ARF6	0,4	Epidermal Growth Factor	ARF6	1950	382	Gene	Gene	Promotes|nmod|START_ENTITY Promotes|nsubj|END_ENTITY	ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast_Cancer Cells in Response to Epidermal_Growth_Factor .
25525271	0	Epidermal_Growth_Factor	0,23	Deleted_in_Liver_Cancer_1	74,99	Epidermal Growth Factor	Deleted in Liver Cancer 1	1950	10395	Gene	Gene	Activates|nsubj|START_ENTITY Activates|dobj|END_ENTITY	Epidermal_Growth_Factor Activates the Rho GTPase-activating Protein -LRB- GAP -RRB- Deleted_in_Liver_Cancer_1 via Focal Adhesion Kinase and Protein Phosphatase_2A .
21804373	0	Epidermal_Growth_Factor	20,43	PDX1	59,63	Epidermal Growth Factor	PDX1	25313(Tax:10116)	29535(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|compound|END_ENTITY	Effects of Combined Epidermal_Growth_Factor and Gastrin on PDX1 Expression in Experimental Type 1 Diabetic Rats .
26508828	0	Epidermal_Growth_Factor_Receptor	96,128	Akt	43,46	Epidermal Growth Factor Receptor	Akt	1956	207	Gene	Gene	Associated|nmod|START_ENTITY Individuals|nmod|Associated Protein_Kinase_B|nmod|Individuals Protein_Kinase_B|appos|END_ENTITY	Decreased Phosphorylated Protein_Kinase_B -LRB- Akt -RRB- in Individuals with Autism Associated with High Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- and Low Gamma-Aminobutyric_Acid -LRB- GABA -RRB- .
26065894	0	Epidermal_Growth_Factor_Receptor	84,116	BRAF	67,71	Epidermal Growth Factor Receptor	BRAF	1956	673	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Mitogen-Inducible_Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal_Growth_Factor_Receptor and Thereby Limits Malignant Transformation .
19464036	0	Epidermal_Growth_Factor_Receptor	34,66	EGFR	68,72	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- in canine mammary tissues .
20509969	0	Epidermal_Growth_Factor_Receptor	14,46	EGFR	48,52	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Assessment of Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- expression in human meningioma .
23608835	0	Epidermal_Growth_Factor_Receptor	30,62	EGFR	64,68	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	The Association Between Tumor Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutation and Multiple Primary Malignancies in Patients With Adenocarcinoma of the Lungs .
25495142	0	Epidermal_Growth_Factor_Receptor	83,115	EGFR	117,121	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	Sea-Urchin-Like Au Nanocluster with Surface-Enhanced Raman Scattering in Detecting Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutation Status of Malignant Pleural Effusion .
25897154	0	Epidermal_Growth_Factor_Receptor	19,51	EGFR	53,57	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Impact of Specific Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutations and Clinical Characteristics on Outcomes After Treatment With EGFR Tyrosine Kinase Inhibitors Versus Chemotherapy in EGFR-Mutant Lung Cancer : A Meta-Analysis .
26191356	0	Epidermal_Growth_Factor_Receptor	18,50	EGFR	52,56	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|appos|END_ENTITY	Inhibitors of the Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- May Provide Effective Treatment for Lung_Adenocarcinoma .
26200642	0	Epidermal_Growth_Factor_Receptor	116,148	EGFR	150,154	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	Ultrasonography-Guided Core Biopsy of Supraclavicular Lymph Nodes for Diagnosis of Metastasis and Identification of Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Mutation in Advanced Lung_Cancer .
26396685	0	Epidermal_Growth_Factor_Receptor	69,101	EGFR	103,107	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Oxopyrido -LSB- 2,3-d -RSB- pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Inhibitors .
26443027	0	Epidermal_Growth_Factor_Receptor	77,109	EGFR	111,115	Epidermal Growth Factor Receptor	EGFR	1956	1956	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Design and Synthesis of Novel Schiff_base-benzothiazole hybrids as potential Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- Inhibitors .
25953087	0	Epidermal_Growth_Factor_Receptor	38,70	ERK	117,120	Epidermal Growth Factor Receptor	ERK	1956	5594	Gene	Gene	Induce|dep|START_ENTITY Induce|dep|Extracellular_Signal-regulated_Kinase Extracellular_Signal-regulated_Kinase|appos|END_ENTITY	Activating PIK3CA Mutations Induce an Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- / Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- Paracrine Signaling Axis in Basal-like Breast_Cancer .
26490843	0	Epidermal_Growth_Factor_Receptor	128,160	Egfr	162,166	Epidermal Growth Factor Receptor	Egfr	378478(Tax:7955)	378478(Tax:7955)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|appos|END_ENTITY	Bisphenol_A and Related_Alkylphenols Exert Nongenomic Estrogenic Actions Through a G_Protein-Coupled_Estrogen_Receptor_1 -LRB- Gper -RRB- / Epidermal_Growth_Factor_Receptor -LRB- Egfr -RRB- Pathway to Inhibit Meiotic Maturation of Zebrafish Oocytes .
26532455	0	Epidermal_Growth_Factor_Receptor	155,187	Egfr	189,193	Epidermal Growth Factor Receptor	Egfr	1956	1956	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	The Impact Of First-Line Tyrosine Kinase Inhibitors -LRB- Tkis -RRB- On Overall Survival In Patients With Advanced_Non-Small_Cell_Lung_Cancer -LRB- Nsclc -RRB- And Activating Epidermal_Growth_Factor_Receptor -LRB- Egfr -RRB- Mutations : Meta-Analysis Of Major Randomized Trials By Mutation Type .
26534371	0	Epidermal_Growth_Factor_Receptor	227,259	Egfr	261,265	Epidermal Growth Factor Receptor	Egfr	1956	1956	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Cost Distribution Analysis Related to the Use of Tyrisine-Kinase Inhibitors -LRB- Tki -RRB- and the Combination of Pemetrexed/Cisplatin in the Treatment of Non-Small_Cell_Lung_Cancer -LRB- Nsclc -RRB- Locally Advanced or Metastatic in Presence of Epidermal_Growth_Factor_Receptor -LRB- Egfr -RRB- Mutations in a Mexican Institutional Context .
26065894	0	Epidermal_Growth_Factor_Receptor	84,116	Mitogen-Inducible_Gene-6	0,24	Epidermal Growth Factor Receptor	Mitogen-Inducible Gene-6	1956	54206	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Mitogen-Inducible_Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal_Growth_Factor_Receptor and Thereby Limits Malignant Transformation .
25573952	0	Epidermal_Growth_Factor_Receptor	21,53	p53	7,10	Epidermal Growth Factor Receptor	p53	1956	7157	Gene	Gene	Signaling|compound|START_ENTITY Amplifies|dobj|Signaling Amplifies|nsubj|END_ENTITY	Mutant p53 Amplifies Epidermal_Growth_Factor_Receptor Family Signaling to Promote Mammary Tumorigenesis .
22329800	0	Epidermal_growth_factor	0,23	AKR1B10	46,53	Epidermal growth factor	AKR1B10	1950	57016	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Epidermal_growth_factor induces tumour marker AKR1B10 expression through activator_protein-1 signalling in hepatocellular_carcinoma cells .
1458840	0	Epidermal_growth_factor	0,23	ATP_citrate_lyase	45,62	Epidermal growth factor	ATP citrate lyase	25313(Tax:10116)	24159(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- stimulation of ATP_citrate_lyase activity in isolated rat hepatocytes is age dependent .
12837294	0	Epidermal_growth_factor	0,23	Bcl-xL	92,98	Epidermal growth factor	Bcl-xL	1950	598	Gene	Gene	inhibition|amod|START_ENTITY involves|nsubj|inhibition involves|dobj|upregulation upregulation|amod|END_ENTITY	Epidermal_growth_factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells .
14502606	0	Epidermal_growth_factor	0,23	Bcl-xL	32,38	Epidermal growth factor	Bcl-xL	1950	598	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Epidermal_growth_factor induces Bcl-xL gene expression and reduces apoptosis in porcine parthenotes developing in vitro .
15798095	0	Epidermal_growth_factor	0,23	CCN5	39,43	Epidermal growth factor	CCN5	1950	8839	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Epidermal_growth_factor induces WISP-2 / CCN5 expression in estrogen_receptor-alpha-positive breast_tumor cells through multiple molecular cross-talks .
8674281	0	Epidermal_growth_factor	0,23	CD44	102,106	Epidermal growth factor	CD44	13645(Tax:10090)	12505(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Epidermal_growth_factor modulates cell attachment to hyaluronic acid by the cell surface glycoprotein CD44 .
9162042	0	Epidermal_growth_factor	0,23	CD44	32,36	Epidermal growth factor	CD44	13645(Tax:10090)	12505(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Epidermal_growth_factor induces CD44 gene expression through a novel regulatory element in mouse fibroblasts .
15802268	0	Epidermal_growth_factor	0,23	CXC_chemokine_receptor_4	58,82	Epidermal growth factor	CXC chemokine receptor 4	1950	7852	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Epidermal_growth_factor and hypoxia-induced expression of CXC_chemokine_receptor_4 on non-small_cell_lung_cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT / mammalian_target_of_rapamycin signaling pathway and activation of hypoxia_inducible_factor-1alpha .
11159799	0	Epidermal_growth_factor	0,23	CYP2A1	55,61	Epidermal growth factor	CYP2A1	25313(Tax:10116)	24894(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Epidermal_growth_factor regulation of female-dependent CYP2A1 and CYP2C12 in primary rat hepatocyte culture .
22401280	0	Epidermal_growth_factor	0,23	CYR61	48,53	Epidermal growth factor	CYR61	1950	3491	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Epidermal_growth_factor upregulates endometrial CYR61 expression via activation of the JAK2/STAT3 pathway .
15373782	0	Epidermal_growth_factor	0,23	EGF	30,33	Epidermal growth factor	EGF	1950	1950	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epidermal_growth_factor gene -LRB- EGF -RRB- polymorphism and risk of melanocytic_neoplasia .
1910383	0	Epidermal_growth_factor	1,24	EGF	26,29	Epidermal growth factor	EGF	1950	1950	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	-LSB- Epidermal_growth_factor -LRB- EGF -RRB- receptors in squamous_cell_carcinoma of the head_and_neck region -RSB- .
24905473	0	Epidermal_growth_factor	0,23	ERK	123,126	Epidermal growth factor	ERK	1950	2048	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|compound|END_ENTITY	Epidermal_growth_factor inhibits transforming_growth_factor-b-induced fibrogenic differentiation marker expression through ERK activation .
11535237	0	Epidermal_growth_factor	0,23	Egr-1	80,85	Epidermal growth factor	Egr-1	1950	1958	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor and platelet-derived growth factor induce expression of Egr-1 , a zinc finger transcription factor , in human malignant_glioma cells .
20578063	0	Epidermal_growth_factor	0,23	MMP-9	63,68	Epidermal growth factor	MMP-9	521832(Tax:9913)	282871(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells .
20375273	0	Epidermal_growth_factor	0,23	NHE8	44,48	Epidermal growth factor	NHE8	1950	23315	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Epidermal_growth_factor inhibits intestinal NHE8 expression via reducing its basal transcription .
24462842	0	Epidermal_growth_factor	0,23	Nestin	52,58	Epidermal growth factor	Nestin	25313(Tax:10116)	25491(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor increases the expression of Nestin in rat reactive astrocytes through the Ras-Raf-ERK pathway .
22270267	0	Epidermal_growth_factor	0,23	PDX1	39,43	Epidermal growth factor	PDX1	25313(Tax:10116)	29535(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Epidermal_growth_factor and gastrin on PDX1 expression in experimental type 1 diabetic rats .
20150581	0	Epidermal_growth_factor	0,23	Rho_A	76,81	Epidermal growth factor	Rho A	1950	387	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|compound|END_ENTITY	Epidermal_growth_factor stimulates human trophoblast cell migration through Rho_A and Rho C activation .
7681824	0	Epidermal_growth_factor	0,23	SHC	67,70	Epidermal growth factor	SHC	13645(Tax:10090)	20416(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHC in the mouse .
9344856	0	Epidermal_growth_factor	0,23	SHP-2	105,110	Epidermal growth factor	SHP-2	1950	5781	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	Epidermal_growth_factor	0,23	SHPS-1	67,73	Epidermal growth factor	SHPS-1	1950	140885	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	Epidermal_growth_factor	0,23	SHPS-1	93,99	Epidermal growth factor	SHPS-1	1950	140885	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
17991704	0	Epidermal_growth_factor	0,23	Src	58,61	Epidermal growth factor	Src	13645(Tax:10090)	20779(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Epidermal_growth_factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration .
8071311	0	Epidermal_growth_factor	0,23	Stat3	56,61	Epidermal growth factor	Stat3	13645(Tax:10090)	20848(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|factor factor|amod|END_ENTITY	Epidermal_growth_factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver .
7538664	0	Epidermal_growth_factor	0,23	Stat_5	90,96	Epidermal growth factor	Stat 5	13645(Tax:10090)	20850(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor induces the tyrosine phosphorylation and nuclear translocation of Stat_5 in mouse liver .
15798095	0	Epidermal_growth_factor	0,23	WISP-2	32,38	Epidermal growth factor	WISP-2	1950	8839	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Epidermal_growth_factor induces WISP-2 / CCN5 expression in estrogen_receptor-alpha-positive breast_tumor cells through multiple molecular cross-talks .
7542259	0	Epidermal_growth_factor	0,23	ZO-1	106,110	Epidermal growth factor	ZO-1	1950	7082	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells .
14662770	0	Epidermal_growth_factor	0,23	androgen_receptor	54,71	Epidermal growth factor	androgen receptor	1950	367	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|coactivation coactivation|nmod|END_ENTITY	Epidermal_growth_factor increases coactivation of the androgen_receptor in recurrent prostate_cancer .
22922989	0	Epidermal_growth_factor	0,23	androgen_receptor	92,109	Epidermal growth factor	androgen receptor	1950	367	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Epidermal_growth_factor induces bladder_cancer cell proliferation through activation of the androgen_receptor .
24126741	0	Epidermal_growth_factor	0,23	androgen_receptor	33,50	Epidermal growth factor	androgen receptor	13645(Tax:10090)	11835(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Epidermal_growth_factor enhances androgen_receptor - mediated bladder_cancer progression and invasion via potentiation of AR transactivation .
1902475	0	Epidermal_growth_factor	0,23	c-fos	86,91	Epidermal growth factor	c-fos	1950	2353	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|binding binding|nmod|protein protein|amod|complex complex|nmod|element element|amod|END_ENTITY	Epidermal_growth_factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells .
3125035	0	Epidermal_growth_factor	0,23	c-fos	75,80	Epidermal growth factor	c-fos	1950	2353	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|messenger messenger|amod|END_ENTITY	Epidermal_growth_factor , but not thyrotropin , stimulates the expression of c-fos and c-myc messenger ribonucleic_acid in porcine thyroid follicle cells in primary culture .
2136806	0	Epidermal_growth_factor	0,23	calpactin_II	52,64	Epidermal growth factor	calpactin II	25313(Tax:10116)	25380(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|accumulation accumulation|nmod|END_ENTITY	Epidermal_growth_factor induces the accumulation of calpactin_II on the cell surface during membrane ruffling .
11684338	0	Epidermal_growth_factor	0,23	connexin-43	39,50	Epidermal growth factor	connexin-43	25313(Tax:10116)	24392(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Epidermal_growth_factor down-regulates connexin-43 expression in cultured rat cortical astrocytes .
22611165	0	Epidermal_growth_factor	0,23	connexin_43	34,45	Epidermal growth factor	connexin 43	1950	2697	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Epidermal_growth_factor regulates connexin_43 in the human epididymis : role of gap junctions in azoospermia .
6146981	0	Epidermal_growth_factor	0,23	cyclin	70,76	Epidermal growth factor	cyclin	1950	5111	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|END_ENTITY	Epidermal_growth_factor inhibits the synthesis of the nuclear protein cyclin in A431 human carcinoma cells .
9568675	0	Epidermal_growth_factor	0,23	cyclin_D1	32,41	Epidermal growth factor	cyclin D1	1950	595	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Epidermal_growth_factor induces cyclin_D1 in a human prostate_cancer cell line .
20856226	0	Epidermal_growth_factor	0,23	cytokeratin_19	32,46	Epidermal growth factor	cytokeratin 19	1950	3880	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Epidermal_growth_factor induces cytokeratin_19 expression accompanied by increased_growth_abilities in human hepatocellular_carcinoma .
7649158	0	Epidermal_growth_factor	0,23	cytosolic_phospholipase_A2	125,151	Epidermal growth factor	cytosolic phospholipase A2	1950	5321	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic_phospholipase_A2 .
11528371	0	Epidermal_growth_factor	0,23	decay-accelerating_factor	46,71	Epidermal growth factor	decay-accelerating factor	1950	1604	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor induces expression of decay-accelerating_factor in human colonic_cancer cells via the mitogen-activated protein kinase pathway .
3872442	0	Epidermal_growth_factor	0,23	epidermal_growth_factor	83,106	Epidermal growth factor	epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Epidermal_growth_factor in mouse ocular tissue : effects of thyroxine and exogenous epidermal_growth_factor .
6290036	0	Epidermal_growth_factor	0,23	epidermal_growth_factor	48,71	Epidermal growth factor	epidermal growth factor	1950	1950	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Epidermal_growth_factor receptors and effect of epidermal_growth_factor on growth of human breast_cancer cells in long-term tissue culture .
18685792	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	63,95	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|changes changes|nmod|interaction interaction|nmod|END_ENTITY	Epidermal_growth_factor induces changes of interaction between epidermal_growth_factor_receptor and actin in intact cells .
19766894	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	33,65	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|amod|END_ENTITY	Epidermal_growth_factor promotes epidermal_growth_factor_receptor nuclear accumulation by a pathway dependent on cytoskeleton integrity in human breast_cancer cells .
20073577	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	75,107	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|death death|nmod|absence absence|nmod|END_ENTITY	Epidermal_growth_factor induces cell death in the absence of overexpressed epidermal_growth_factor_receptor and ErbB2 in various human cancer cell lines .
2162268	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	118,150	Epidermal growth factor	epidermal growth factor receptor	25313(Tax:10116)	24329(Tax:10116)	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|parataxis|role role|nmod|END_ENTITY	Epidermal_growth_factor accelerates functional recovery from ischaemic acute_tubular_necrosis in the rat : role of the epidermal_growth_factor_receptor .
3494473	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	78,110	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|aggregation aggregation|nmod|END_ENTITY	Epidermal_growth_factor induces rapid , reversible aggregation of the purified epidermal_growth_factor_receptor .
6321474	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	66,98	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	promoters|compound|START_ENTITY induce|nsubj|promoters induce|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Epidermal_growth_factor and potent phorbol tumor promoters induce epidermal_growth_factor_receptor phosphorylation in a similar but distinctively different manner in human epidermoid_carcinoma A431 cells .
7508718	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	110,142	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	induced|compound|START_ENTITY tyrosine|nsubj|induced tyrosine|dobj|phosphorylation phosphorylation|nmod|proteins proteins|acl|associated associated|nmod|translocation translocation|nmod|END_ENTITY	Epidermal_growth_factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal_growth_factor_receptor into the nucleus .
7558411	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	83,115	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	expression|amod|START_ENTITY expression|dep|down-regulates down-regulates|amod|END_ENTITY	Epidermal_growth_factor expression in human colon_and_colon_carcinomas : anti-sense epidermal_growth_factor_receptor RNA down-regulates the proliferation of human colon_cancer cells .
8262933	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	89,121	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|kinase kinase|acl:relcl|separable separable|nmod|END_ENTITY	Epidermal_growth_factor stimulates a protein tyrosine kinase which is separable from the epidermal_growth_factor_receptor .
8785711	0	Epidermal_growth_factor	0,23	epidermal_growth_factor_receptor	77,109	Epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	mediated|nsubj|START_ENTITY mediated|nmod|cells cells|nmod|END_ENTITY	Epidermal_growth_factor mediated DNA delivery into lung_cancer cells via the epidermal_growth_factor_receptor .
8246947	0	Epidermal_growth_factor	0,23	extracellular_signal-regulated_kinase_2	51,90	Epidermal growth factor	extracellular signal-regulated kinase 2	25313(Tax:10116)	116590(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor induces phosphorylation of extracellular_signal-regulated_kinase_2 via multiple pathways .
9933031	0	Epidermal_growth_factor	0,23	extracellular_signal-regulated_protein_kinase	57,102	Epidermal growth factor	extracellular signal-regulated protein kinase	25313(Tax:10116)	24338(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Epidermal_growth_factor and angiotensin_II regulation of extracellular_signal-regulated_protein_kinase in rat liver epithelial WB cells .
3107554	0	Epidermal_growth_factor	0,23	glucocorticoid_receptor	69,92	Epidermal growth factor	glucocorticoid receptor	1950	2908	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates tyrosine phosphorylation of human glucocorticoid_receptor in cultured cells .
10861232	0	Epidermal_growth_factor	0,23	glutathione_S-transferase	38,63	Epidermal growth factor	glutathione S-transferase	25313(Tax:10116)	58962(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Epidermal_growth_factor regulation of glutathione_S-transferase gene expression in the rat is mediated by class Pi glutathione_S-transferase enhancer I. Using chloramphenicol acetyltransferase assays we showed that epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- , and 3,3 ' ,4,4 ' ,5 - pentachlorobiphenyl -LRB- PenCB -RRB- induce class Pi glutathione_S-transferase -LRB- GSTP1 -RRB- in primary cultured rat liver parenchymal cells .
16107595	0	Epidermal_growth_factor	0,23	growth_hormone	31,45	Epidermal growth factor	growth hormone	1950	2688	Gene	Gene	and/or|compound|START_ENTITY END_ENTITY|nsubj|and/or	Epidermal_growth_factor and/or growth_hormone induce differential , side-specific signal transduction protein phosphorylation in enterocytes .
6611253	0	Epidermal_growth_factor	0,23	growth_hormone	35,49	Epidermal growth factor	growth hormone	25313(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Epidermal_growth_factor stimulates growth_hormone secretion from superfused rat adenohypophyseal fragments .
11262389	0	Epidermal_growth_factor	0,23	hyaluronan_synthase_2	34,55	Epidermal growth factor	hyaluronan synthase 2	25313(Tax:10116)	25694(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Epidermal_growth_factor activates hyaluronan_synthase_2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan .
2827626	0	Epidermal_growth_factor	0,23	insulin	61,68	Epidermal growth factor	insulin	1950	3630	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|effect effect|nmod|END_ENTITY	Epidermal_growth_factor counteracts the glycogenic effect of insulin in parenchymal hepatocyte cultures .
9759855	0	Epidermal_growth_factor	0,23	insulin	104,111	Epidermal growth factor	insulin	1950	3630	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- modulates fetal thymocyte growth and differentiation : partial reversal by insulin , mimicking by specific inhibitors of EGF receptor tyrosine kinase activity , and differential expression of CD45 phosphatase isotypes .
1380055	0	Epidermal_growth_factor	0,23	insulin-like_growth_factor-binding_protein-1	49,93	Epidermal growth factor	insulin-like growth factor-binding protein-1	1950	3484	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Epidermal_growth_factor stimulates production of insulin-like_growth_factor-binding_protein-1 in human granulosa-luteal cells .
8140119	0	Epidermal_growth_factor	0,23	interleukin-1	73,86	Epidermal growth factor	interleukin-1	1950	3552	Gene	Gene	enhance|nsubj|START_ENTITY enhance|dobj|production production|amod|END_ENTITY	Epidermal_growth_factor and transforming_growth_factor-alpha enhance the interleukin-1 - and tumor_necrosis_factor-stimulated prostaglandin_E2 production and the interleukin-1 specific binding on amnion cells .
11277615	0	Epidermal_growth_factor	0,23	interleukin-4_receptor	62,84	Epidermal growth factor	interleukin-4 receptor	1950	3566	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor regulates astrocyte expression of the interleukin-4_receptor via a MAPK-independent pathway .
16678783	0	Epidermal_growth_factor	0,23	interleukin-8	49,62	Epidermal growth factor	interleukin-8	1950	3576	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Epidermal_growth_factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1beta .
3261877	0	Epidermal_growth_factor	0,23	intrinsic_factor	44,60	Epidermal growth factor	intrinsic factor	1950	2694	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- inhibits both intrinsic_factor secretion and acid secretion in histamine-stimulated isolated gastric glands .
15802268	0	Epidermal_growth_factor	0,23	mammalian_target_of_rapamycin	178,207	Epidermal growth factor	mammalian target of rapamycin	1950	2475	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Epidermal_growth_factor and hypoxia-induced expression of CXC_chemokine_receptor_4 on non-small_cell_lung_cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT / mammalian_target_of_rapamycin signaling pathway and activation of hypoxia_inducible_factor-1alpha .
2475642	0	Epidermal_growth_factor	0,23	myelin_basic_protein	51,71	Epidermal growth factor	myelin basic protein	13645(Tax:10090)	17196(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor inhibits the expression of myelin_basic_protein in oligodendrocytes .
24048788	0	Epidermal_growth_factor	0,23	neutrophil_gelatinase-associated_lipocalin	57,99	Epidermal growth factor	neutrophil gelatinase-associated lipocalin	1950	3934	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor down-regulates the expression of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- through E-cadherin in pancreatic_cancer cells .
3109985	0	Epidermal_growth_factor	0,23	ornithine_decarboxylase	53,76	Epidermal growth factor	ornithine decarboxylase	1950	4953	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|induction induction|nmod|activity activity|amod|END_ENTITY	Epidermal_growth_factor potentiates the induction of ornithine_decarboxylase activity by prostaglandins in embryonic_palate mesenchymal cells : effects on cell proliferation and glycosaminoglycan synthesis .
6197492	0	Epidermal_growth_factor	0,23	ornithine_decarboxylase	35,58	Epidermal growth factor	ornithine decarboxylase	1950	4953	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Epidermal_growth_factor stimulates ornithine_decarboxylase activity in cultured mammalian keratinocytes .
6265908	0	Epidermal_growth_factor	0,23	ornithine_decarboxylase	39,62	Epidermal growth factor	ornithine decarboxylase	1950	4953	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Epidermal_growth_factor stimulation of ornithine_decarboxylase activity in a human hepatoma cell line .
8162329	0	Epidermal_growth_factor	0,23	ornithine_decarboxylase	32,55	Epidermal growth factor	ornithine decarboxylase	1950	4953	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Epidermal_growth_factor induces ornithine_decarboxylase in SV40-immortalized human keratinocytes .
8190004	0	Epidermal_growth_factor	0,23	ornithine_decarboxylase	55,78	Epidermal growth factor	ornithine decarboxylase	1950	4953	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Epidermal_growth_factor induces biphasic activation of ornithine_decarboxylase in human stomach-derived KATO-III cells .
7673364	0	Epidermal_growth_factor	0,23	phospholipase_C-gamma_1	67,90	Epidermal growth factor	phospholipase C-gamma 1	1950	5335	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	Epidermal_growth_factor induces rapid and transient association of phospholipase_C-gamma_1 with EGF-receptor and filamentous actin at membrane ruffles of A431 cells .
1454826	0	Epidermal_growth_factor	0,23	placental_lactogen_I	41,61	Epidermal growth factor	placental lactogen I	13645(Tax:10090)	18775(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Epidermal_growth_factor stimulates mouse placental_lactogen_I but inhibits mouse placental_lactogen_II secretion in vitro .
2631032	0	Epidermal_growth_factor	1,24	progesterone_receptor	37,58	Epidermal growth factor	progesterone receptor	100714471	100724945	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	-LSB- Epidermal_growth_factor induces the progesterone_receptor in fetal uterine cells in culture : antagonistic effect of antiestrogens -RSB- .
2323487	0	Epidermal_growth_factor	0,23	prolactin	51,60	Epidermal growth factor	prolactin	25313(Tax:10116)	24683(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Epidermal_growth_factor and phorbol_ester regulate prolactin gene expression via distinct pathways .
8388615	0	Epidermal_growth_factor	0,23	prolactin	39,48	Epidermal growth factor	prolactin	25313(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|amod|END_ENTITY	Epidermal_growth_factor stimulates the prolactin synthesis and secretion in rat pituitary cells in culture -LRB- GH4C1 cells -RRB- by increasing the intracellular concentration of free calcium .
8102801	0	Epidermal_growth_factor	0,23	protein-tyrosine-phosphatase	55,83	Epidermal growth factor	protein-tyrosine-phosphatase	1950	26191	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Epidermal_growth_factor stimulates substrate-selective protein-tyrosine-phosphatase activity .
21273531	0	Epidermal_growth_factor	0,23	serotonin_transporter	36,57	Epidermal growth factor	serotonin transporter	1950	6532	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Epidermal_growth_factor upregulates serotonin_transporter in human intestinal epithelial cells via transcriptional mechanisms .
25309082	0	Epidermal_growth_factor	0,23	serotonin_transporter	36,57	Epidermal growth factor	serotonin transporter	25313(Tax:10116)	25553(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Epidermal_growth_factor upregulates serotonin_transporter and its association with visceral_hypersensitivity in irritable_bowel_syndrome .
6102094	0	Epidermal_growth_factor	0,23	tyrosine_hydroxylase	32,52	Epidermal growth factor	tyrosine hydroxylase	1950	7054	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Epidermal_growth_factor induces tyrosine_hydroxylase in a clonal pheochromocytoma cell line , PC-G2 .
15491342	0	Epidermal_growth_factor	0,23	urokinase-type_plasminogen_activator	35,71	Epidermal growth factor	urokinase-type plasminogen activator	1950	5328	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Epidermal_growth_factor stimulates urokinase-type_plasminogen_activator expression in human gingival fibroblasts .
11330643	0	Epidermal_growth_factor	0,23	vascular_endothelial_growth_factor	52,86	Epidermal growth factor	vascular endothelial growth factor	1950	7422	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor modulates the expression of vascular_endothelial_growth_factor in the human prostate .
1711046	0	Epidermal_growth_factor	0,23	vinculin	38,46	Epidermal growth factor	vinculin	13645(Tax:10090)	22330(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Epidermal_growth_factor activation of vinculin and beta 1-integrin gene transcription in quiescent Swiss_3T3 cells .
20837907	0	Epidermal_growth_factor-like_domain_7	0,37	intercellular_adhesion_molecule_1	49,82	Epidermal growth factor-like domain 7	intercellular adhesion molecule 1	51162	3383	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Epidermal_growth_factor-like_domain_7 suppresses intercellular_adhesion_molecule_1 expression in response to hypoxia/reoxygenation injury in human coronary artery endothelial cells .
18813952	0	Epidermal_growth_factor_receptor	0,32	Akt	69,72	Epidermal growth factor receptor	Akt	1956	207	Gene	Gene	status|amod|START_ENTITY status|nmod|pathways pathways|compound|END_ENTITY	Epidermal_growth_factor_receptor status and persistent activation of Akt and p44/42 MAPK pathways correlate with the effect of cetuximab in head and neck and colon_cancer cell lines .
19002495	0	Epidermal_growth_factor_receptor	0,32	Akt	94,97	Epidermal growth factor receptor	Akt	1956	207	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Epidermal_growth_factor_receptor mutations in non-small_cell_lung_cancer influence downstream Akt , MAPK and Stat3 signaling .
16472596	0	Epidermal_growth_factor_receptor	0,32	Bax	53,56	Epidermal growth factor receptor	Bax	13649(Tax:10090)	12028(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling regulates|dobj|expression expression|compound|END_ENTITY	Epidermal_growth_factor_receptor signaling regulates Bax and Bcl-w expression and apoptotic responses during intestinal adaptation in mice .
22517768	0	Epidermal_growth_factor_receptor	0,32	COX-2	105,110	Epidermal growth factor receptor	COX-2	1956	4513	Gene	Gene	transactivation|compound|START_ENTITY required|nsubjpass|transactivation required|nmod|expression expression|compound|END_ENTITY	Epidermal_growth_factor_receptor transactivation is required for proteinase-activated_receptor-2-induced COX-2 expression in intestinal epithelial cells .
15540509	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene Bsr I polymorphism is associated with systemic_lupus_erythematosus .
15570078	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- status in primary colorectal_tumors does not correlate with EGFR expression in related metastatic sites : implications for treatment with EGFR-targeted monoclonal antibodies .
15980160	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- status in primary colorectal_tumors correlates with EGFR expression in related metastatic sites : biological and clinical implications .
16097449	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in childhood brain_tumors .
17516110	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression is associated with a worse prognosis in gastric_cancer patients undergoing curative surgery .
17595771	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation does not correlate with platinum resistance in ovarian_carcinoma .
18409189	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in prostatic_adenocarcinoma after hormonal therapy : a fluorescence in situ hybridization and immunohistochemical analysis .
19922469	0	Epidermal_growth_factor_receptor	0,32	EGFR	67,71	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	Epidermal_growth_factor_receptor in relation to tumor development : EGFR gene and cancer .
22668015	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression and mutations in the EGFR signaling pathway in correlation with anti-EGFR therapy in head_and_neck_squamous_cell_carcinomas .
25211582	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in lung_cancer : preclinical and clinical data .
25296354	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in lung_cancer : preclinical and clinical data .
26755002	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene amplification in high-grade gliomas : Western Indian tertiary cancer center experience .
27040854	0	Epidermal_growth_factor_receptor	0,32	EGFR	34,38	Epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in small_cell_lung_cancers : Two cases and a review of the literature .
7718322	0	Epidermal_growth_factor_receptor	0,32	EGFr	34,38	Epidermal growth factor receptor	EGFr	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFr -RRB- expression in non-small_cell_lung_carcinomas correlates with metastatic involvement of hilar and mediastinal lymph nodes in the squamous subtype .
22117074	0	Epidermal_growth_factor_receptor	0,32	ERK1/2	123,129	Epidermal growth factor receptor	ERK1/2	1956	5595;5594	Gene	Gene	START_ENTITY|dep|feedback feedback|nmod|epsilon epsilon|nmod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- - mediated positive feedback of protein-tyrosine phosphatase epsilon -LRB- PTPepsilon -RRB- on ERK1/2 and AKT protein pathways is required for survival of human breast_cancer cells .
18178562	0	Epidermal_growth_factor_receptor	0,32	ERK2	102,106	Epidermal growth factor receptor	ERK2	1956	5594	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Epidermal_growth_factor_receptor and protein_kinase_C signaling to ERK2 : spatiotemporal regulation of ERK2 by dual specificity phosphatases .
18178562	0	Epidermal_growth_factor_receptor	0,32	ERK2	67,71	Epidermal growth factor receptor	ERK2	1956	5594	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Epidermal_growth_factor_receptor and protein_kinase_C signaling to ERK2 : spatiotemporal regulation of ERK2 by dual specificity phosphatases .
16741920	0	Epidermal_growth_factor_receptor	0,32	ErbB1	34,39	Epidermal growth factor receptor	ErbB1	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- ErbB1 -RRB- expression in prostate_cancer progression : correlation with androgen independence .
18276593	0	Epidermal_growth_factor_receptor	0,32	Erk1/2	46,52	Epidermal growth factor receptor	Erk1/2	1956	5595;5594	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Epidermal_growth_factor_receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus_infection .
19820359	0	Epidermal_growth_factor_receptor	0,32	MT1-MMP	43,50	Epidermal growth factor receptor	MT1-MMP	1956	4323	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|amod|END_ENTITY	Epidermal_growth_factor_receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways .
10435153	0	Epidermal_growth_factor_receptor	0,32	PCNA	77,81	Epidermal growth factor receptor	PCNA	1956	5111	Gene	Gene	START_ENTITY|appos|proliferating_cell_nuclear_antigen proliferating_cell_nuclear_antigen|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- , proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- and Ki-67 antigen in laryngeal epithelial lesions .
16407214	0	Epidermal_growth_factor_receptor	0,32	Src	71,74	Epidermal growth factor receptor	Src	1956	6714	Gene	Gene	exposed|nsubj|START_ENTITY exposed|nmod|trafficking trafficking|amod|END_ENTITY	Epidermal_growth_factor_receptor exposed to oxidative stress undergoes Src - and caveolin-1-dependent perinuclear trafficking .
17875215	0	Epidermal_growth_factor_receptor	0,32	Y-box_binding_protein-1	76,99	Epidermal growth factor receptor	Y-box binding protein-1	1956	4904	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- is transcriptionally induced by the Y-box_binding_protein-1 -LRB- YB-1 -RRB- and can be inhibited with Iressa in basal-like breast_cancer , providing a potential target for therapy .
17942395	0	Epidermal_growth_factor_receptor	0,32	amphiregulin	61,73	Epidermal growth factor receptor	amphiregulin	1956	374	Gene	Gene	analysis|amod|START_ENTITY identifies|nsubj|analysis identifies|dobj|END_ENTITY	Epidermal_growth_factor_receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast_cancer cells .
11304462	0	Epidermal_growth_factor_receptor	0,32	angiotensin_II	52,66	Epidermal growth factor receptor	angiotensin II	1956	183	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	Epidermal_growth_factor_receptor transactivation by angiotensin_II requires reactive oxygen species in vascular smooth muscle cells .
12063263	0	Epidermal_growth_factor_receptor	0,32	c-Cbl	84,89	Epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	activation|amod|START_ENTITY fails|nsubj|activation fails|xcomp|promote promote|dobj|down-regulation down-regulation|amod|END_ENTITY	Epidermal_growth_factor_receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation .
24039221	0	Epidermal_growth_factor_receptor	0,32	cyclin_D1	39,48	Epidermal growth factor receptor	cyclin D1	1956	595	Gene	Gene	p16|compound|START_ENTITY p16|nummod|END_ENTITY	Epidermal_growth_factor_receptor , p16 , cyclin_D1 , and p53 staining patterns for inverted_papilloma .
9012840	0	Epidermal_growth_factor_receptor	0,32	cyclooxygenase-2	73,89	Epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	activation|compound|START_ENTITY induces|nsubj|activation induces|dobj|nuclear nuclear|nmod|release release|amod|END_ENTITY	Epidermal_growth_factor_receptor activation induces nuclear targeting of cyclooxygenase-2 , basolateral release of prostaglandins , and mitogenesis in polarizing colon_cancer cells .
8251654	0	Epidermal_growth_factor_receptor	0,32	epidermal_growth_factor_receptor	53,85	Epidermal growth factor receptor	epidermal growth factor receptor	1956	1956	Gene	Gene	increase|amod|START_ENTITY increase|nmod|END_ENTITY	Epidermal_growth_factor_receptor levels increase but epidermal_growth_factor_receptor ligand levels decrease in mouse mammary_tumors during progression from hormone dependence to hormone independence .
11601336	0	Epidermal_growth_factor_receptor	0,32	growth_hormone	49,63	Epidermal growth factor receptor	growth hormone	24329(Tax:10116)	81668(Tax:10116)	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	Epidermal_growth_factor_receptor participates in growth_hormone signaling pathway in cardiac myocytes of neonatal rat .
20154724	0	Epidermal_growth_factor_receptor	0,32	hypoxia-inducible_factor-1alpha	79,110	Epidermal growth factor receptor	hypoxia-inducible factor-1alpha	1956	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Epidermal_growth_factor_receptor regulates MET levels and invasiveness through hypoxia-inducible_factor-1alpha in non-small_cell_lung_cancer cells .
15520175	0	Epidermal_growth_factor_receptor	0,32	insulin-like_growth_factor-binding_protein_3	66,110	Epidermal growth factor receptor	insulin-like growth factor-binding protein 3	1956	3486	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Epidermal_growth_factor_receptor regulates aberrant expression of insulin-like_growth_factor-binding_protein_3 .
10767376	0	Epidermal_growth_factor_receptor	0,32	p53	119,122	Epidermal growth factor receptor	p53	1956	7157	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|overexpression overexpression|compound|END_ENTITY	Epidermal_growth_factor_receptor expression correlates with poor prognosis in non-small_cell_lung_cancer patients with p53 overexpression .
12154062	0	Epidermal_growth_factor_receptor	0,32	p53	97,100	Epidermal growth factor receptor	p53	13649(Tax:10090)	22060(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY associated|nsubjpass|pathways associated|dep|model model|nummod|END_ENTITY	Epidermal_growth_factor_receptor signaling pathways are associated with tumorigenesis in the Nf1 : p53 mouse tumor model .
21388911	0	Epidermal_growth_factor_receptor	0,32	p53	66,69	Epidermal growth factor receptor	p53	1956	7157	Gene	Gene	abundance|nsubj|START_ENTITY abundance|dobj|correlates correlates|nmod|accumulation accumulation|compound|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- abundance correlates with p53 and Bcl-2 accumulation and patient age in a small cohort of North African nasopharyngeal_carcinoma patients .
22692198	0	Epidermal_growth_factor_receptor	0,32	proliferating_cell_nuclear_antigen	42,76	Epidermal growth factor receptor	proliferating cell nuclear antigen	1956	5111	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Epidermal_growth_factor_receptor protects proliferating_cell_nuclear_antigen from cullin_4A protein-mediated proteolysis .
17909010	0	Epidermal_growth_factor_receptor	0,32	signal_transducer_and_activator_of_transcription_3	49,99	Epidermal growth factor receptor	signal transducer and activator of transcription 3	1956	6774	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Epidermal_growth_factor_receptor cooperates with signal_transducer_and_activator_of_transcription_3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression .
16487602	0	Epidermodysplasia_verruciformis_1	18,51	EVER1	53,58	Epidermodysplasia verruciformis 1	EVER1	11322	11322	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Four mutations in Epidermodysplasia_verruciformis_1 -LRB- EVER1 -RRB- gene are not contributors to susceptibility in RRP .
12164918	0	Epilysin	0,8	MMP-28	10,16	Epilysin	MMP-28	79148	79148	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Epilysin -LRB- MMP-28 -RRB- expression is associated with cell proliferation during epithelial repair .
14581411	0	Epiregulin	0,10	ERK	63,66	Epiregulin	ERK	2069	5594	Gene	Gene	released|nsubj|START_ENTITY released|nmod|cells cells|amod|END_ENTITY	Epiregulin as a major autocrine/paracrine factor released from ERK - and p38MAPK-activated vascular smooth muscle cells .
18620900	0	Epiregulin	0,10	ERK	120,123	Epiregulin	ERK	2069	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Epiregulin promotes migration and invasion of salivary adenoid_cystic_carcinoma cell line SACC-83 through activation of ERK and Akt .
23734838	0	Epiregulin	0,10	ERK1/2	62,68	Epiregulin	ERK1/2	2069	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway .
18948081	0	Epiregulin	0,10	Ets-1	25,30	Epiregulin	Ets-1	2069	2113	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Epiregulin expression by Ets-1 and ERK signaling pathway in Ki-ras-transformed cells .
9419975	0	Epiregulin	0,10	epidermal_growth_factor_receptor	20,52	Epiregulin	epidermal growth factor receptor	2069	1956	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Epiregulin binds to epidermal_growth_factor_receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal_growth_factor_receptor , ErbB-2 , ErbB-3 and ErbB-4 .
9424019	0	Epiregulin	0,10	epidermal_growth_factor_receptor	114,146	Epiregulin	epidermal growth factor receptor	100343410(Tax:9986)	100008806(Tax:9986)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|autophosphorylation autophosphorylation|nmod|END_ENTITY	Epiregulin stimulates proliferation of rabbit gastric cells in primary culture through autophosphorylation of the epidermal_growth_factor_receptor .
26401964	0	Epithelial_Cell_Adhesion_Molecule	14,47	EpCAM	49,54	Epithelial Cell Adhesion Molecule	EpCAM	4072	4072	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Epithelial_Cell_Adhesion_Molecule -LRB- EpCAM -RRB- in oral_squamous_cell_Carcinoma .
10806352	0	Epithelial_Protein_Lost_in_Neoplasm	37,72	EPLIN	30,35	Epithelial Protein Lost in Neoplasm	EPLIN	51474	51474	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the human EPLIN -LRB- Epithelial_Protein_Lost_in_Neoplasm -RRB- gene reveals distinct promoters for the two EPLIN isoforms .
21799003	0	Epithelial_cell_adhesion_molecule	0,33	EpCAM	35,40	Epithelial cell adhesion molecule	EpCAM	17075(Tax:10090)	17075(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Epithelial_cell_adhesion_molecule -LRB- EpCAM -RRB- complex proteins promote transcription factor-mediated pluripotency reprogramming .
19996184	0	Epithelial_cell_transforming_protein_2	0,38	ECT2	40,44	Epithelial cell transforming protein 2	ECT2	13605(Tax:10090)	13605(Tax:10090)	Gene	Gene	depletion|amod|START_ENTITY depletion|appos|END_ENTITY	Epithelial_cell_transforming_protein_2 -LRB- ECT2 -RRB- depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles .
21637765	0	Epithelial_membrane_protein-2	0,29	FAK	89,92	Epithelial membrane protein-2	FAK	2013	5747	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Epithelial_membrane_protein-2 promotes endometrial_tumor formation through activation of FAK and Src .
26876307	0	Epithelial_membrane_protein_2	0,29	keratin_8	76,85	Epithelial membrane protein 2	keratin 8	2013	3856	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Epithelial_membrane_protein_2 regulates sphingosylphosphorylcholine-induced keratin_8 phosphorylation and reorganization : Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung_cancer cells .
15987600	0	Epithelium-specific_ets_transcription_factor_2	0,46	cytokeratin_18	143,157	Epithelium-specific ets transcription factor 2	cytokeratin 18	2001	3875	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|interaction interaction|nmod|intron intron|compound|END_ENTITY	Epithelium-specific_ets_transcription_factor_2 upregulates cytokeratin_18 expression in pulmonary epithelial cells through an interaction with cytokeratin_18 intron 1 .
15987600	0	Epithelium-specific_ets_transcription_factor_2	0,46	cytokeratin_18	59,73	Epithelium-specific ets transcription factor 2	cytokeratin 18	2001	3875	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Epithelium-specific_ets_transcription_factor_2 upregulates cytokeratin_18 expression in pulmonary epithelial cells through an interaction with cytokeratin_18 intron 1 .
26897933	0	Epo	36,39	EpoR	70,74	Epo	EpoR	2056	2057	Gene	Gene	Erythropoietin|appos|START_ENTITY Erythropoietin|appos|END_ENTITY	Mystery Story about Erythropoietin -LRB- Epo -RRB- and Erythropoietin_Receptor -LRB- EpoR -RRB- are Disguised ?
18682290	0	Epo	80,83	Jak2	23,27	Epo	Jak2	2056	3717	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway .
7528577	0	Epo	63,66	erythropoietin	47,61	Epo	erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Hematopoietic_cell_phosphatase associates with erythropoietin -LRB- Epo -RRB- receptor after Epo-induced receptor tyrosine phosphorylation : identification of potential binding sites .
26897933	0	EpoR	70,74	Epo	36,39	EpoR	Epo	2057	2056	Gene	Gene	Erythropoietin|appos|START_ENTITY Erythropoietin|appos|END_ENTITY	Mystery Story about Erythropoietin -LRB- Epo -RRB- and Erythropoietin_Receptor -LRB- EpoR -RRB- are Disguised ?
8523512	0	Epoc-1	100,106	skn-1a	107,113	Epoc-1	skn-1a	25833	25833	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|parataxis|END_ENTITY	Regulation of human_papillomavirus transcription by the differentiation-dependent epithelial factor Epoc-1 / skn-1a .
19835873	0	Eps15	0,5	Cx43	35,39	Eps15	Cx43	2060	2697	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Eps15 interacts with ubiquitinated Cx43 and mediates its internalization .
9049247	0	Eps15	34,39	adaptor_protein-2	45,62	Eps15	adaptor protein-2	2060	7020	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association and colocalization of Eps15 with adaptor_protein-2 and clathrin .
16036216	0	Eps15	59,64	spartin	36,43	Eps15	spartin	2060	23111	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Troyer_syndrome -LRB- SPG20 -RRB- protein spartin interacts with Eps15 .
26039045	0	Eps8	12,16	Brain-Derived_Neurotrophic_Factor	82,115	Eps8	Brain-Derived Neurotrophic Factor	2059	627	Gene	Gene	Filopodia|compound|START_ENTITY Filopodia|nmod|Neurons Neurons|nmod|END_ENTITY	Correction : Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- .
16868024	0	Eps8	18,22	Palladin	0,8	Eps8	Palladin	2059	27143	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells .
25359883	0	Eps8	0,4	Src	14,17	Eps8	Src	13860(Tax:10090)	20779(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Eps8 controls Src - and FAK-dependent phenotypes in squamous_carcinoma cells .
19564905	0	Eps8	0,4	brain-derived_neurotrophic_factor	70,103	Eps8	brain-derived neurotrophic factor	13860(Tax:10090)	12064(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived_neurotrophic_factor -LRB- BDNF -RRB- .
8404850	0	Eps8	0,4	epidermal_growth_factor_receptor	26,58	Eps8	epidermal growth factor receptor	2059	1956	Gene	Gene	START_ENTITY|appos|substrate substrate|nmod|kinase kinase|compound|END_ENTITY	Eps8 , a substrate for the epidermal_growth_factor_receptor kinase , enhances EGF-dependent mitogenic signals .
19528316	0	Eps8	84,88	lanthionine_synthetase_C-like_protein_1	19,58	Eps8	lanthionine synthetase C-like protein 1	2059	10314	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of human lanthionine_synthetase_C-like_protein_1 and its interaction with Eps8 and glutathione .
21116212	0	Epsin_4	43,50	CLINT1	35,41	Epsin 4	CLINT1	9685	9685	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Association study of the GRIA1 and CLINT1 -LRB- Epsin_4 -RRB- genes in a German schizophrenia sample .
16616458	0	Epsin_4	36,43	ENTH	30,34	Epsin 4	ENTH	9685	9685	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic analysis of the human ENTH -LRB- Epsin_4 -RRB- gene and schizophrenia .
18307776	0	Er81	0,4	Pax6	31,35	Er81	Pax6	2115	5080	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Er81 is a downstream target of Pax6 in cortical progenitors .
11624347	1	Era	115,118	Era	130,133	Era	Era	26284	26284	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Histories of medical advertisements from Taisho Era till Showa Era -RSB- .
11624347	1	Era	130,133	Era	115,118	Era	Era	26284	26284	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Histories of medical advertisements from Taisho Era till Showa Era -RSB- .
22417306	0	ErbB	3,7	AP-1	26,30	ErbB	AP-1	1956	3726	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	An ErbB receptor-mediated AP-1 regulatory network is modulated by STAT3 and c-MYC during calcium-dependent keratinocyte differentiation .
18760695	0	ErbB	13,17	Neuregulin-1	0,12	ErbB	Neuregulin-1	13649(Tax:10090)	211323(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY serves|nsubj|signaling END_ENTITY|parataxis|serves	Neuregulin-1 / ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system .
20933198	0	ErbB	13,17	Neuregulin-1	0,12	ErbB	Neuregulin-1	1956	3084	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Neuregulin-1 / ErbB signaling and chronic_heart_failure .
21172654	0	ErbB	65,69	P-Rex1	30,36	ErbB	P-Rex1	1956	57580	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast_cancer .
17716876	0	ErbB	26,30	PI3K	0,4	ErbB	PI3K	724072(Tax:8355)	373752(Tax:8355)	Gene	Gene	MAPK|dobj|START_ENTITY MAPK|nsubj|END_ENTITY	PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation .
10582594	0	ErbB	88,92	Shc	110,113	ErbB	Shc	13649(Tax:10090)	20416(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Neuregulin-increased expression of acetylcholine receptor epsilon-subunit gene requires ErbB interaction with Shc .
19805360	0	ErbB	60,64	Shp2	25,29	ErbB	Shp2	13649(Tax:10090)	19247(Tax:10090)	Gene	Gene	directs|dobj|START_ENTITY directs|nsubj|END_ENTITY	The tyrosine phosphatase Shp2 -LRB- PTPN11 -RRB- directs Neuregulin-1 / ErbB signaling throughout Schwann cell development .
8617810	0	ErbB	4,8	epidermal_growth_factor_receptor	34,66	ErbB	epidermal growth factor receptor	1956	1956	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	All ErbB receptors other than the epidermal_growth_factor_receptor are endocytosis impaired .
12838503	0	ErbB	44,48	neuregulin-1	31,43	ErbB	neuregulin-1	1956	3084	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Constitutive activation of the neuregulin-1 / ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line .
15897877	0	ErbB	31,35	neuregulin-1	18,30	ErbB	neuregulin-1	1956	3084	Gene	Gene	signaling|compound|START_ENTITY promotes|nsubj|signaling Activation|parataxis|promotes Activation|nmod|END_ENTITY	Activation of the neuregulin-1 / ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant_peripheral_nerve_sheath_tumors .
16432850	0	ErbB	26,30	neuregulin-1	13,25	ErbB	neuregulin-1	1956	3084	Gene	Gene	signaling|compound|START_ENTITY contributes|nsubj|signaling END_ENTITY|parataxis|contributes	Constitutive neuregulin-1 / ErbB signaling contributes to human vestibular_schwannoma proliferation .
17709650	0	ErbB	21,25	neuregulin-1	8,20	ErbB	neuregulin-1	1956	3084	Gene	Gene	signaling|compound|START_ENTITY Role|dep|signaling Role|nmod|END_ENTITY	Role of neuregulin-1 / ErbB signaling in cardiovascular physiology and disease : implications for therapy of heart_failure .
20682778	0	ErbB	133,137	neuregulin-1	120,132	ErbB	neuregulin-1	1956	3084	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Direct binding of the EGF-like domain of neuregulin-1 to integrins -LRB- -LCB- alpha -RCB- v -LCB- beta -RCB- 3_and _ -LCB- alpha -RCB- 6 -LCB- beta -RCB- 4 -RRB- is involved in neuregulin-1 / ErbB signaling .
20682778	0	ErbB	133,137	neuregulin-1	41,53	ErbB	neuregulin-1	1956	3084	Gene	Gene	signaling|compound|START_ENTITY involved|nmod|signaling involved|nsubjpass|binding binding|nmod|domain domain|nmod|integrins integrins|amod|END_ENTITY	Direct binding of the EGF-like domain of neuregulin-1 to integrins -LRB- -LCB- alpha -RCB- v -LCB- beta -RCB- 3_and _ -LCB- alpha -RCB- 6 -LCB- beta -RCB- 4 -RRB- is involved in neuregulin-1 / ErbB signaling .
18523588	0	ErbB	35,39	nucleolin	18,27	ErbB	nucleolin	1956	4691	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Identification of nucleolin as new ErbB receptors - interacting protein .
11244498	0	ErbB-2	14,20	ErbB-2_and_type_I_insulin-like_growth_factor_receptor	60,113	ErbB-2	ErbB-2 and type I insulin-like growth factor receptor	2064	2064	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of ErbB-2 via a hierarchical interaction between ErbB-2_and_type_I_insulin-like_growth_factor_receptor in mammary tumor cells .
15112275	0	ErbB-2	36,42	HER-2	30,35	ErbB-2	HER-2	2064	2064	Gene	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of P-glycoprotein , HER-2 / ErbB-2 , p53 , and Bcl-2 in primary_tumor and metachronous lung metastases in patients with high-grade osteosarcoma .
8999872	0	ErbB-2	70,76	HER-2	64,69	ErbB-2	HER-2	2064	2064	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association of csk-homologous_kinase -LRB- CHK -RRB- -LRB- formerly MATK -RRB- with HER-2 / ErbB-2 in breast_cancer cells .
12967566	0	ErbB-2	20,26	HER2	27,31	ErbB-2	HER2	2064	2064	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Polar expression of ErbB-2 / HER2 in epithelia .
15568014	0	ErbB-2	16,22	HER2	23,27	ErbB-2	HER2	2064	2064	Gene	Gene	START_ENTITY|parataxis|signalling signalling|nsubj|END_ENTITY	Hsp90 restrains ErbB-2 / HER2 signalling by limiting heterodimer formation .
11314013	0	ErbB-2	120,126	Neu	127,130	ErbB-2	Neu	403883(Tax:9615)	2064	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2 / Neu receptor .
15210733	0	ErbB-2	80,86	Plexin-B1	0,9	ErbB-2	Plexin-B1	2064	5364	Gene	Gene	tyrosine|dobj|START_ENTITY involves|ccomp|tyrosine END_ENTITY|parataxis|involves	Plexin-B1 / RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 .
22378040	0	ErbB-2	0,6	Plexin-B1	23,32	ErbB-2	Plexin-B1	2064	5364	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	ErbB-2 signals through Plexin-B1 to promote breast_cancer metastasis .
14586404	0	ErbB-2	19,25	STAT3	47,52	ErbB-2	STAT3	2064	6774	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic_cancer cell lines .
11940572	0	ErbB-2	0,6	Stat3	17,22	ErbB-2	Stat3	2064	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|xcomp|alpha alpha|nsubj|END_ENTITY	ErbB-2 activates Stat3 alpha in a Src - and JAK2-dependent manner .
20876300	0	ErbB-2	127,133	Stat3	163,168	ErbB-2	Stat3	2064	6774	Gene	Gene	function|nsubj|START_ENTITY function|nmod|coactivator coactivator|nmod|END_ENTITY	Progesterone_receptor induces ErbB-2 nuclear translocation to promote breast_cancer growth via a novel transcriptional effect : ErbB-2 function as a coactivator of Stat3 .
20876300	0	ErbB-2	30,36	Stat3	163,168	ErbB-2	Stat3	2064	6774	Gene	Gene	translocation|compound|START_ENTITY induces|dobj|translocation induces|parataxis|function function|nmod|coactivator coactivator|nmod|END_ENTITY	Progesterone_receptor induces ErbB-2 nuclear translocation to promote breast_cancer growth via a novel transcriptional effect : ErbB-2 function as a coactivator of Stat3 .
26212010	0	ErbB-2	16,22	Stat3	0,5	ErbB-2	Stat3	2064	6774	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression , PDCD4 downregulation and breast_cancer metastasis .
10790369	0	ErbB-2	81,87	ZO-1	27,31	ErbB-2	ZO-1	2064	7082	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression .
8999872	0	ErbB-2	70,76	csk-homologous_kinase	15,36	ErbB-2	csk-homologous kinase	2064	4145	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association of csk-homologous_kinase -LRB- CHK -RRB- -LRB- formerly MATK -RRB- with HER-2 / ErbB-2 in breast_cancer cells .
12467226	0	ErbB-2	70,76	epidermal_growth_factor_receptor	37,69	ErbB-2	epidermal growth factor receptor	2064	1956	Gene	Gene	tyrosine|nsubj|START_ENTITY effects|parataxis|tyrosine effects|nmod|END_ENTITY	The effects of the novel , reversible epidermal_growth_factor_receptor / ErbB-2 tyrosine kinase inhibitor , GW2016 , on the growth of human normal and tumor-derived cell lines in vitro and in vivo .
15718311	0	ErbB-2	63,69	epidermal_growth_factor_receptor	16,48	ErbB-2	epidermal growth factor receptor	2064	1956	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Relationship of epidermal_growth_factor_receptor expression to ErbB-2 signaling activity and prognosis in breast_cancer patients .
20924101	0	ErbB-2	37,43	neu	44,47	ErbB-2	neu	24337(Tax:10116)	13866(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY END_ENTITY|dep|expressing	Mesenchymal stromal cells expressing ErbB-2 / neu elicit protective antibreast tumor immunity in vivo , which is paradoxically suppressed by IFN-gamma and tumor_necrosis_factor-alpha priming .
18025083	0	ErbB-2	0,6	plexin-B1	60,69	ErbB-2	plexin-B1	2064	5364	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|signaling signaling|nmod|END_ENTITY	ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1 .
19760502	0	ErbB-2	19,25	tumor_necrosis_factor_alpha	37,64	ErbB-2	tumor necrosis factor alpha	2064	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Transactivation of ErbB-2 induced by tumor_necrosis_factor_alpha promotes NF-kappaB activation and breast_cancer cell proliferation .
11244498	0	ErbB-2_and_type_I_insulin-like_growth_factor_receptor	60,113	ErbB-2	14,20	ErbB-2 and type I insulin-like growth factor receptor	ErbB-2	2064	2064	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of ErbB-2 via a hierarchical interaction between ErbB-2_and_type_I_insulin-like_growth_factor_receptor in mammary tumor cells .
21822299	0	ErbB-3	110,116	Akt	117,120	ErbB-3	Akt	2065	207	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	An ErbB-3 antibody , MP-RM-1 , inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3 / Akt signaling .
21822299	0	ErbB-3	3,9	Akt	117,120	ErbB-3	Akt	2065	207	Gene	Gene	antibody|compound|START_ENTITY inhibits|nsubj|antibody inhibits|advcl|blocking blocking|dobj|activation activation|nmod|signaling signaling|compound|END_ENTITY	An ErbB-3 antibody , MP-RM-1 , inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3 / Akt signaling .
21822299	0	ErbB-3	110,116	ErbB-3	3,9	ErbB-3	ErbB-3	2065	2065	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling blocking|dobj|activation inhibits|advcl|blocking inhibits|nsubj|antibody antibody|compound|END_ENTITY	An ErbB-3 antibody , MP-RM-1 , inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3 / Akt signaling .
21822299	0	ErbB-3	3,9	ErbB-3	110,116	ErbB-3	ErbB-3	2065	2065	Gene	Gene	antibody|compound|START_ENTITY inhibits|nsubj|antibody inhibits|advcl|blocking blocking|dobj|activation activation|nmod|signaling signaling|compound|END_ENTITY	An ErbB-3 antibody , MP-RM-1 , inhibits tumor growth by blocking ligand-dependent and independent activation of ErbB-3 / Akt signaling .
7929212	0	ErbB-3	0,6	Neu_differentiation_factor	84,110	ErbB-3	Neu differentiation factor	2065	3084	Gene	Gene	function|amod|START_ENTITY function|nmod|heregulin heregulin|compound|END_ENTITY	ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu_differentiation_factor / heregulin isoforms .
8524214	0	ErbB-3	41,47	Neu_differentiation_factor	0,26	ErbB-3	Neu differentiation factor	2065	3084	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Neu_differentiation_factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2 .
10682683	0	ErbB-3	45,51	PA2G4	19,24	ErbB-3	PA2G4	2065	5036	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Interaction of the PA2G4 -LRB- EBP1 -RRB- protein with ErbB-3 and regulation of this binding by heregulin .
16741920	0	ErbB1	34,39	Epidermal_growth_factor_receptor	0,32	ErbB1	Epidermal growth factor receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor -LRB- ErbB1 -RRB- expression in prostate_cancer progression : correlation with androgen independence .
15140260	0	ErbB1/2	51,58	Erk	71,74	ErbB1/2	Erk	1956;2064	5594	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Phospholipase_C_delta-4 overexpression upregulates ErbB1/2 expression , Erk signaling pathway , and proliferation in MCF-7 cells .
24463007	0	ErbB2	15,20	AKT3	0,4	ErbB2	AKT3	13866(Tax:10090)	23797(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	AKT3 regulates ErbB2 , ErbB3 and estrogen_receptor_a expression and contributes to endocrine therapy resistance of ErbB2 -LRB- + -RRB- breast_tumor cells from Balb-neuT mice .
9735325	0	ErbB2	20,25	C-Src	0,5	ErbB2	C-Src	2064	6714	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	C-Src activation by ErbB2 leads to attachment-independent growth of human breast epithelial cells .
20010870	0	ErbB2	26,31	Copine-III	0,10	ErbB2	Copine-III	2064	8895	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Copine-III interacts with ErbB2 and promotes tumor cell migration .
24835103	0	ErbB2	66,71	Csk-homologous_kinase	35,56	ErbB2	Csk-homologous kinase	2064	4145	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Trastuzumab-induced recruitment of Csk-homologous_kinase -LRB- CHK -RRB- to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition .
18426980	0	ErbB2	0,5	Dock7	45,50	ErbB2	Dock7	2064	85440	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	ErbB2 directly activates the exchange factor Dock7 to promote Schwann cell migration .
20379846	0	ErbB2	41,46	EBP1	26,30	ErbB2	EBP1	13866(Tax:10090)	18813(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast_cancer cells .
23242156	0	ErbB2	37,42	EBP1	22,26	ErbB2	EBP1	2064	5036	Gene	Gene	levels|amod|START_ENTITY decreases|dobj|levels decreases|nsubj|END_ENTITY	ErbB3-binding protein EBP1 decreases ErbB2 levels via a transcriptional mechanism .
17635524	0	ErbB2	71,76	EGFR	48,52	ErbB2	EGFR	2064	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Assessment of epidermal_growth_factor_receptor -LRB- EGFR , ErbB1 -RRB- and HER2 -LRB- ErbB2 -RRB- protein expression levels and response to lapatinib -LRB- Tykerb , GW572016 -RRB- in an expanded panel of human normal and tumour cell lines .
17700572	0	ErbB2	130,135	EGFR	118,122	ErbB2	EGFR	2064	1956	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	NF-kappaB activation in inflammatory breast_cancer is associated with oestrogen_receptor downregulation , secondary to EGFR and/or ErbB2 overexpression and MAPK hyperactivation .
11062025	0	ErbB2	47,52	EGF_receptor	58,70	ErbB2	EGF receptor	2064	1956	Gene	Gene	coexpressing|dobj|START_ENTITY coexpressing|nmod|END_ENTITY	Enhanced drug resistance in cells coexpressing ErbB2 with EGF_receptor or ErbB3 .
22190492	0	ErbB2	26,31	EGF_receptor	13,25	ErbB2	EGF receptor	2064	1956	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Mechanics of EGF_receptor / ErbB2 kinase activation revealed by luciferase fragment complementation imaging .
12032832	0	ErbB2	0,5	ESX	20,23	ErbB2	ESX	2064	1999	Gene	Gene	activation|amod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	ErbB2 activation of ESX gene expression .
18079969	0	ErbB2	130,135	EphA2	29,34	ErbB2	EphA2	13866(Tax:10090)	13836(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma_tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling .
15300809	0	ErbB2	71,76	ErbB2	98,103	ErbB2	ErbB2	2064	2064	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a small peptide that inhibits the phosphorylation of ErbB2 and proliferation of ErbB2 overexpressing breast_cancer cells .
15300809	0	ErbB2	98,103	ErbB2	71,76	ErbB2	ErbB2	2064	2064	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a small peptide that inhibits the phosphorylation of ErbB2 and proliferation of ErbB2 overexpressing breast_cancer cells .
12853564	0	ErbB2	60,65	ErbB3	75,80	ErbB2	ErbB3	2064	2065	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	The ErbB2/ErbB3 heterodimer functions as an oncogenic unit : ErbB2 requires ErbB3 to drive breast_tumor cell proliferation .
23698633	0	ErbB2	48,53	ErbB3	72,77	ErbB2	ErbB3	2064	2065	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3 .
17825601	0	ErbB2	0,5	FAS	31,34	ErbB2	FAS	2064	2194	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	ErbB2 and fatty_acid synthase -LRB- FAS -RRB- expression in 102 squamous_cell_carcinomas of the tongue : correlation with clinical outcomes .
12629518	0	ErbB2	80,85	Gab1	0,4	ErbB2	Gab1	13866(Tax:10090)	14388(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2 .
18594210	0	ErbB2	50,55	Granulocyte-colony_stimulating_factor	0,37	ErbB2	Granulocyte-colony stimulating factor	2064	1440	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Granulocyte-colony_stimulating_factor upregulates ErbB2 expression on breast_cancer cell lines and converts primary resistance to trastuzumab .
12072561	0	ErbB2	28,33	HER2	35,39	ErbB2	HER2	2064	2064	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Conditional mutation of the ErbB2 -LRB- HER2 -RRB- receptor in cardiomyocytes leads to dilated_cardiomyopathy .
16847283	0	ErbB2	63,68	HER2/Neu	53,61	ErbB2	HER2/Neu	2064	2064	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Can trastuzumab be effective against tumors with low HER2/Neu -LRB- ErbB2 -RRB- receptors ?
17721278	0	ErbB2	115,120	HER2/neu	122,130	ErbB2	HER2/neu	2064	2064	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	PGDS , a novel technique combining chromogenic in situ hybridization and immunohistochemistry for the assessment of ErbB2 -LRB- HER2/neu -RRB- status in breast_cancer .
19782563	0	ErbB2	14,19	Her2	20,24	ErbB2	Her2	2064	2064	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of ErbB2 -LRB- Her2 -RRB- expression with small molecule transcription factor mimics .
22847003	0	ErbB2	39,44	Her2/Neu	46,54	ErbB2	Her2/Neu	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Heat_shock factor Hsf1 cooperates with ErbB2 -LRB- Her2/Neu -RRB- protein to promote mammary tumorigenesis and metastasis .
11892991	0	ErbB2	83,88	Hsp90	0,5	ErbB2	Hsp90	2064	3320	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Hsp90 , not Grp94 , regulates the intracellular trafficking and stability of nascent ErbB2 .
18397823	0	ErbB2	20,25	MUC4	0,4	ErbB2	MUC4	2064	4585	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	MUC4 interacts with ErbB2 in human gallbladder_carcinoma : potential pathobiological implications .
15499570	0	ErbB2	42,47	Muc4	77,81	ErbB2	Muc4	24337(Tax:10116)	303887(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression , location , and interactions of ErbB2 and its intramembrane ligand Muc4 -LRB- sialomucin_complex -RRB- in rat mammary gland during pregnancy .
17292332	0	ErbB2	35,40	Muc4	0,4	ErbB2	Muc4	2064	4585	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Muc4 is required for activation of ErbB2 in signet ring carcinoma cell lines .
20443831	0	ErbB2	0,5	Notch1	14,20	ErbB2	Notch1	2064	4851	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	ErbB2 induces Notch1 activity and function in breast_cancer cells .
20335174	0	ErbB2	56,61	PTPN9	29,34	ErbB2	PTPN9	2064	5780	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal_growth_factor_receptor signaling in breast_cancer cells .
15753384	0	ErbB2	0,5	Src	15,18	ErbB2	Src	2064	6714	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|synthesis synthesis|compound|END_ENTITY	ErbB2 promotes Src synthesis and stability : novel mechanisms of Src activation that confer breast_cancer metastasis .
18724389	0	ErbB2	67,72	WW_domain_containing_E3_ubiquitin_protein_ligase_1	4,54	ErbB2	WW domain containing E3 ubiquitin protein ligase 1	2064	11059	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	The WW_domain_containing_E3_ubiquitin_protein_ligase_1 upregulates ErbB2 and EGFR through RING_finger_protein_11 .
19704002	0	ErbB2	22,27	c-Src	0,5	ErbB2	c-Src	2064	6714	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential .
15375338	0	ErbB2	0,5	erbB3	14,19	ErbB2	erbB3	2064	2065	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	ErbB2 without erbB3 expression in metaplastic columnar epithelium of Barrett 's _ esophagus .
12477051	0	ErbB2	30,35	histone_deacetylase	39,58	ErbB2	histone deacetylase	2064	9734	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Transcriptional repression of ErbB2 by histone_deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen .
20332114	0	ErbB2	0,5	integrin_alpha5	15,30	ErbB2	integrin alpha5	2064	3678	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	ErbB2 requires integrin_alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells .
9590694	0	ErbB2	15,20	interleukin-6	39,52	ErbB2	interleukin-6	2064	3569	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Requirement of ErbB2 for signalling by interleukin-6 in prostate_carcinoma cells .
27065318	0	ErbB2	22,27	miR-155	0,7	ErbB2	miR-155	2064	406947	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells .
19931543	0	ErbB2	125,130	neu	132,135	ErbB2	neu	2064	2064	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The effect of hydrophilic substitutions and anionic lipids upon the transverse positioning of the transmembrane helix of the ErbB2 -LRB- neu -RRB- protein incorporated into model membrane vesicles .
16698793	0	ErbB2	21,26	neuregulin-1	8,20	ErbB2	neuregulin-1	24337(Tax:10116)	112400(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY Role|parataxis|signaling Role|nmod|END_ENTITY	Role of neuregulin-1 / ErbB2 signaling in endothelium-cardiomyocyte cross-talk .
23466678	0	ErbB2	0,5	neuregulin-1	58,70	ErbB2	neuregulin-1	13866(Tax:10090)	211323(Tax:10090)	Gene	Gene	dephosphorylation|amod|START_ENTITY dephosphorylation|nmod|cells cells|amod|END_ENTITY	ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells ; re-evaluation of their low-affinity interaction .
9637684	0	ErbB2	4,9	neuregulin-1	48,60	ErbB2	neuregulin-1	13866(Tax:10090)	211323(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The ErbB2 and ErbB3 receptors and their ligand , neuregulin-1 , are essential for development of the sympathetic nervous system .
19951994	0	ErbB2	62,67	neutrophil_gelatinase-associated_lipocalin	16,58	ErbB2	neutrophil gelatinase-associated lipocalin	2064	3934	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of neutrophil_gelatinase-associated_lipocalin by ErbB2 through nuclear factor-kappaB activation .
17457047	0	ErbB3	0,5	EGFR	39,43	ErbB3	EGFR	2065	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	ErbB3 expression and dimerization with EGFR influence pancreatic_cancer cell sensitivity to erlotinib .
18398842	0	ErbB3	32,37	EGFR	41,45	ErbB3	EGFR	2065	1956	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells .
12853564	0	ErbB3	75,80	ErbB2	60,65	ErbB3	ErbB2	2065	2064	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	The ErbB2/ErbB3 heterodimer functions as an oncogenic unit : ErbB2 requires ErbB3 to drive breast_tumor cell proliferation .
23698633	0	ErbB3	72,77	ErbB2	48,53	ErbB3	ErbB2	2065	2064	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3 .
21368164	0	ErbB3	31,36	HER3	25,29	ErbB3	HER3	2065	2065	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Feedback upregulation of HER3 -LRB- ErbB3 -RRB- expression and activity attenuates antitumor effect of PI3K inhibitors .
21385943	0	ErbB3	61,66	HER3	55,59	ErbB3	HER3	2065	2065	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Transcriptional and posttranslational up-regulation of HER3 -LRB- ErbB3 -RRB- compensates for inhibition of the HER2 tyrosine kinase .
19797898	0	ErbB3	42,47	VEGF	18,22	ErbB3	VEGF	2065	7422	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Heregulin-induced VEGF expression via the ErbB3 signaling pathway in colon_cancer .
20587519	0	ErbB3	29,34	androgen_receptor	53,70	ErbB3	androgen receptor	2065	367	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Nrdp1-mediated regulation of ErbB3 expression by the androgen_receptor in androgen-dependent but not castrate-resistant prostate_cancer cells .
9693119	0	ErbB3	86,91	epidermal_growth_factor	23,46	ErbB3	epidermal growth factor	2065	1950	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Signal transduction by epidermal_growth_factor and heregulin via the kinase-deficient ErbB3 protein .
12411582	0	ErbB3	129,134	epidermal_growth_factor_receptor	81,113	ErbB3	epidermal growth factor receptor	2065	1956	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal_growth_factor_receptor family member , ErbB3 .
21930127	0	ErbB3	16,21	p48	39,42	ErbB3	p48	2065	10379	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Long isoform of ErbB3 binding protein , p48 , mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization .
24798454	0	ErbB3-binding_protein-1	33,56	miR-1	172,177	ErbB3-binding protein-1	miR-1	5036	79187	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Androgen_receptor -LRB- AR -RRB- inhibitor ErbB3-binding_protein-1 -LRB- Ebp1 -RRB- is not targeted by the newly identified AR controlling signaling axis_heat-shock_protein_HSP27 and microRNA miR-1 in prostate_cancer cells .
20048076	0	ErbB3_binding_protein_1	0,23	anterior_gradient_protein_2	60,87	ErbB3 binding protein 1	anterior gradient protein 2	5036	10551	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	ErbB3_binding_protein_1 represses metastasis-promoting gene anterior_gradient_protein_2 in prostate_cancer .
23769722	0	ErbB4	28,33	CADM1	7,12	ErbB4	CADM1	13869(Tax:10090)	54725(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Necl-2 / CADM1 interacts with ErbB4 and regulates its activity in GABAergic neurons .
24142862	0	ErbB4	24,29	Cdk5	0,4	ErbB4	Cdk5	2066	1020	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons .
22378872	0	ErbB4	28,33	NRG-1	22,27	ErbB4	NRG-1	13869(Tax:10090)	211323(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The importance of the NRG-1 / ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric_disorders .
23703525	0	ErbB4	13,18	Neuregulin-1	0,12	ErbB4	Neuregulin-1	59323(Tax:10116)	112400(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|parataxis|regulates	Neuregulin-1 / ErbB4 signaling regulates Kv4.2-mediated transient outward K + current through the Akt/mTOR pathway .
20080551	0	ErbB4	53,58	Neuregulin_1	0,12	ErbB4	Neuregulin 1	13869(Tax:10090)	211323(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Neuregulin_1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons .
21195117	0	ErbB4	27,32	Presenilin-1	0,12	ErbB4	Presenilin-1	13869(Tax:10090)	19164(Tax:10090)	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation .
21617117	0	ErbB4	33,38	TNF	58,61	ErbB4	TNF	2066	7124	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	TNF-a_converting_enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival .
25052836	0	ErbB4	20,25	TrkB	0,4	ErbB4	TrkB	2066	4915	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis .
24308844	0	ErbB4	60,65	WWOX	35,39	ErbB4	WWOX	2066	51741	Gene	Gene	tyrosine|amod|START_ENTITY suppressor|nmod|tyrosine suppressor|amod|binding binding|nmod|END_ENTITY	Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase .
19561640	0	ErbB4	75,80	WW_domain_containing_E3_ubiquitin_protein_ligase_1	0,50	ErbB4	WW domain containing E3 ubiquitin protein ligase 1	2066	11059	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	WW_domain_containing_E3_ubiquitin_protein_ligase_1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast_cancer .
17909041	0	ErbB4	25,30	Wwox	15,19	ErbB4	Wwox	2066	51741	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Wwox with ErbB4 in breast_cancer .
24472438	0	ErbB4	71,76	YAP	34,37	ErbB4	YAP	2066	10413	Gene	Gene	tyrosine|amod|START_ENTITY regulator|nmod|tyrosine regulator|amod|binding binding|nmod|END_ENTITY	Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase .
16819515	0	ErbB4	0,5	c-Jun	61,66	ErbB4	c-Jun	2066	3725	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	ErbB4 -LRB- JM-b/CYT -1 -RRB- - induced expression and phosphorylation of c-Jun is abrogated by human_papillomavirus_type_16 E5 protein .
20585313	0	ErbB4	0,5	cyclooxygenase-2	15,31	ErbB4	cyclooxygenase-2	13869(Tax:10090)	19225(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells .
24589589	0	ErbB4	20,25	miR-520a	1,9	ErbB4	miR-520a	2066	574467	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- miR-520a regulates ErbB4 expression and suppresses proliferation and invasion of esophageal_squamous_cell_carcinoma -RSB- .
24462774	0	ErbB4	48,53	presenilin-1	12,24	ErbB4	presenilin-1	13869(Tax:10090)	19164(Tax:10090)	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation .
19458253	0	Erbin	0,5	NRG1	16,20	Erbin	NRG1	59079(Tax:10090)	211323(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	Erbin regulates NRG1 signaling and myelination .
11279080	0	Erbin	0,5	PSD-95	78,84	Erbin	PSD-95	55914	1742	Gene	Gene	protein|nsubj|START_ENTITY protein|acl|concentrated concentrated|nmod|membranes membranes|acl:relcl|interacts interacts|nmod|END_ENTITY	Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95 .
24142719	0	Erbin	0,5	Sema4C	21,27	Erbin	Sema4C	55914	54910	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells .
23354328	0	Erbin	0,5	TARP	21,25	Erbin	TARP	59079(Tax:10090)	94242(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Erbin interacts with TARP y-2 for surface expression of AMPA receptors in cortical interneurons .
19289088	0	Erbin	0,5	TGF-beta	106,114	Erbin	TGF-beta	55914	7040	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta .
25521828	0	Erbin	0,5	c-Cbl	21,26	Erbin	c-Cbl	59079(Tax:10090)	12402(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal_cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR .
22880131	0	Erbin	51,56	c-Myb	0,5	Erbin	c-Myb	55914	4602	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	c-Myb regulates cell cycle-dependent expression of Erbin : an implication for a novel function of Erbin .
22880131	0	Erbin	97,102	c-Myb	0,5	Erbin	c-Myb	55914	4602	Gene	Gene	function|nmod|START_ENTITY implication|nmod|function expression|dep|implication regulates|dobj|expression regulates|nsubj|END_ENTITY	c-Myb regulates cell cycle-dependent expression of Erbin : an implication for a novel function of Erbin .
17591701	0	Erbin	0,5	transforming_growth_factor_beta	15,46	Erbin	transforming growth factor beta	55914	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Erbin inhibits transforming_growth_factor_beta signaling through a novel Smad-interacting_domain .
25139621	0	Erg	0,3	TGF-b	20,25	Erg	TGF-b	2078	7040	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|END_ENTITY	Erg cooperates with TGF-b to control mesenchymal differentiation .
18195090	0	Erg	21,24	VE-cadherin	82,93	Erg	VE-cadherin	2078	1003	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin .
10543768	0	Erg11p	18,24	GAL1	44,48	Erg11p	GAL1	856398(Tax:4932)	852308(Tax:4932)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Overexpression of Erg11p by the regulatable GAL1 promoter confers fluconazole resistance in Saccharomyces_cerevisiae .
22613993	0	Ergic2	0,6	Otoferlin	48,57	Ergic2	Otoferlin	67456(Tax:10090)	83762(Tax:10090)	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Ergic2 , a brain specific interacting partner of Otoferlin .
17663748	0	Erk	94,97	Bad	47,50	Erk	Bad	24338(Tax:10116)	64639(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Contrasting roles of neuronal Msk1 and Rsk2 in Bad phosphorylation and feedback regulation of Erk signalling .
18218778	0	Erk	43,46	Bit1	17,21	Erk	Bit1	26413(Tax:10090)	217057(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Anoikis effector Bit1 negatively regulates Erk activity .
20956544	0	Erk	72,75	EGFR	51,55	Erk	EGFR	5594	1956	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	ErbB2 stabilizes epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression via Erk and Sprouty2 in extracellular matrix-detached cells .
15140260	0	Erk	71,74	ErbB1/2	51,58	Erk	ErbB1/2	5594	1956;2064	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Phospholipase_C_delta-4 overexpression upregulates ErbB1/2 expression , Erk signaling pathway , and proliferation in MCF-7 cells .
26183471	0	Erk	109,112	FGFR4	9,14	Erk	FGFR4	5594	2264	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	FGF-1 / -3 / FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon_cancer through Erk and MMP-7 .
20652960	0	Erk	16,19	FRS2a	0,5	Erk	FRS2a	26413(Tax:10090)	327826(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	FRS2a regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells .
25363403	0	Erk	40,43	G-protein_coupled_receptor_34	0,29	Erk	G-protein coupled receptor 34	26413(Tax:10090)	23890(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY activates|dobj|pathways activates|nsubj|END_ENTITY	G-protein_coupled_receptor_34 activates Erk and phosphatidylinositol 3-kinase/Akt pathways and functions as alternative pathway to mediate p185Bcr-Abl-induced transformation_and_leukemogenesis .
18682601	0	Erk	48,51	IL-4	0,4	Erk	IL-4	5594	3565	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	IL-4 protein expression and basal activation of Erk in vivo in follicular_lymphoma .
10402237	0	Erk	29,32	K-ras	86,91	Erk	K-ras	5594	3845	Gene	Gene	activity|appos|START_ENTITY MAP|dobj|activity MAP|nmod|expression expression|compound|END_ENTITY	Lack of elevated MAP kinase -LRB- Erk -RRB- activity in pancreatic_carcinomas despite oncogenic K-ras expression .
16904289	0	Erk	43,46	MAGI-3	0,6	Erk	MAGI-3	5594	260425	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	MAGI-3 regulates LPA-induced activation of Erk and RhoA .
23246965	0	Erk	18,21	MKP3	36,40	Erk	MKP3	5594	1848	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	/ \ Np63a regulates Erk signaling via MKP3 to inhibit cancer metastasis .
24602610	0	Erk	47,50	MKP3	109,113	Erk	MKP3	26413(Tax:10090)	67603(Tax:10090)	Gene	Gene	MAP|compound|START_ENTITY kinase|nsubj|MAP kinase|nmod|induction induction|nmod|MAP_kinase_phosphatase_3 MAP_kinase_phosphatase_3|appos|END_ENTITY	Constitutively active Ras negatively regulates Erk MAP kinase through induction of MAP_kinase_phosphatase_3 -LRB- MKP3 -RRB- in NIH3T3 cells .
26981366	0	Erk	39,42	Mek	82,85	Erk	Mek	26413(Tax:10090)	17242(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	RNA sequencing analysis to demonstrate Erk dependent and independent functions of Mek .
9796699	0	Erk	75,78	NF1	0,3	Erk	NF1	26413(Tax:10090)	18015(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY lymphogenesis|acl|activating cooperates|nmod|lymphogenesis cooperates|nsubj|inactivation inactivation|compound|END_ENTITY	NF1 inactivation cooperates with N-ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity .
22981863	0	Erk	16,19	Pak1	83,87	Erk	Pak1	5594	5058	Gene	Gene	activation|compound|START_ENTITY activation|dep|END_ENTITY	LAT-independent Erk activation via Bam32-PLC-y1-Pak1 complexes : GTPase-independent Pak1 activation .
26808296	0	Erk	80,83	Snail	28,33	Erk	Snail	5594	6615	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Helicobacter_pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3b in human gastric_cancer cells .
24497027	0	Erk	38,41	Sos1	0,4	Erk	Sos1	5594	6654	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Sos1 regulates sustained TCR-mediated Erk activation .
26373733	0	Erk	24,27	Tubb3	0,5	Erk	Tubb3	26413(Tax:10090)	22152(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Tubb3 regulation by the Erk and Akt signaling pathways : a mechanism involved in the effect of arginine_ADP-ribosyltransferase_1 -LRB- Art1 -RRB- on apoptosis of colon_carcinoma CT26 cells .
17046786	0	Erk	35,38	Vimentin	0,8	Erk	Vimentin	5594	7431	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase .
22782886	0	Erk	15,18	ZO-1	0,4	Erk	ZO-1	26413(Tax:10090)	21872(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	ZO-1 regulates Erk , Smad1/5/8 , Smad2 , and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells .
17475774	0	Erk	80,83	epidermal_growth_factor_receptor	47,79	Erk	epidermal growth factor receptor	2048	1956	Gene	Gene	signaling|nsubj|START_ENTITY Inhibition|parataxis|signaling Inhibition|nmod|END_ENTITY	Inhibition of integrin-mediated crosstalk with epidermal_growth_factor_receptor / Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death .
20956544	0	Erk	72,75	epidermal_growth_factor_receptor	17,49	Erk	epidermal growth factor receptor	5594	1956	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	ErbB2 stabilizes epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression via Erk and Sprouty2 in extracellular matrix-detached cells .
24790701	0	Erk	97,100	myosin_Va	83,92	Erk	myosin Va	5594	4644	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin_Va via Erk signaling .
9553146	0	Erk	57,60	p38	18,21	Erk	p38	5594	1432	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway .
14597634	0	Erk	89,92	tumor_necrosis_factor-alpha	123,150	Erk	tumor necrosis factor-alpha	5594	7124	Gene	Gene	START_ENTITY|nmod|cells cells|acl|stimulated stimulated|nmod|END_ENTITY	Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor_necrosis_factor-alpha .
9078246	0	Erk-1	153,158	granulocyte-colony-stimulating_factor	73,110	Erk-1	granulocyte-colony-stimulating factor	5595	1440	Gene	Gene	activation|nmod|START_ENTITY response|dep|activation response|nmod|END_ENTITY	cAMP suppresses p21ras and Raf-1 responses but not the Erk-1 response to granulocyte-colony-stimulating_factor : possible Raf-1-independent activation of Erk-1 .
9078246	0	Erk-1	55,60	granulocyte-colony-stimulating_factor	73,110	Erk-1	granulocyte-colony-stimulating factor	5595	1440	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	cAMP suppresses p21ras and Raf-1 responses but not the Erk-1 response to granulocyte-colony-stimulating_factor : possible Raf-1-independent activation of Erk-1 .
16920798	0	Erk1	71,75	bradykinin	122,132	Erk1	bradykinin	5595	3827	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	An internally controlled peripheral biomarker for Alzheimer 's _ disease : Erk1 and Erk2 responses to the inflammatory signal bradykinin .
26716515	0	Erk1/2	110,116	Bim	91,94	Erk1/2	Bim	5595;5594	10018	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Mitotic cell death caused by follistatin-like_1 inhibition is associated with up-regulated Bim by inactivated Erk1/2 in human lung_cancer cells .
19534809	0	Erk1/2	42,48	COX-2	21,26	Erk1/2	COX-2	5595;5594	4513	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Deoxycholate induces COX-2 expression via Erk1/2 - , p38-MAPK and AP-1-dependent mechanisms in esophageal_cancer cells .
25476480	0	Erk1/2	69,75	CrkL	0,4	Erk1/2	CrkL	5595;5594	1399	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CrkL regulates SDF-1-induced breast_cancer biology through balancing Erk1/2 and PI3K/Akt pathways .
18276593	0	Erk1/2	46,52	Epidermal_growth_factor_receptor	0,32	Erk1/2	Epidermal growth factor receptor	5595;5594	1956	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Epidermal_growth_factor_receptor signaling to Erk1/2 and STATs control the intensity of the epithelial inflammatory responses to rhinovirus_infection .
20203690	0	Erk1/2	97,103	GPR30	14,19	Erk1/2	GPR30	5595;5594	2852	Gene	Gene	activation|nmod|START_ENTITY inhibits|nmod|activation inhibits|nsubj|Activation Activation|nmod|END_ENTITY	Activation of GPR30 inhibits the growth of prostate_cancer cells through sustained activation of Erk1/2 , c-jun/c-fos-dependent upregulation of p21 , and induction of G -LRB- 2 -RRB- cell-cycle arrest .
20875696	0	Erk1/2	42,48	GPR30	57,62	Erk1/2	GPR30	5595;5594	2852	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nmod|END_ENTITY	Bisphenol_A induces a rapid activation of Erk1/2 through GPR30 in human breast_cancer cells .
16951370	0	Erk1/2	110,116	IL-17A	0,6	Erk1/2	IL-17A	5595;5594	3605	Gene	Gene	role|dep|START_ENTITY pathways|nsubj|role induces|parataxis|pathways induces|nsubj|END_ENTITY	IL-17A induces eotaxin-1 / CC chemokine ligand 11 expression in human airway_smooth_muscle cells : role of MAPK -LRB- Erk1/2 , JNK , and p38 -RRB- pathways .
22162626	0	Erk1/2	63,69	IL-17A	0,6	Erk1/2	IL-17A	5595;5594	3605	Gene	Gene	mediators|nmod|START_ENTITY production|nmod|mediators stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-17A stimulates the production of inflammatory mediators via Erk1/2 , p38 MAPK , PI3K/Akt , and NF-kB pathways in ARPE-19 cells .
26262610	0	Erk1/2	61,67	MITF	77,81	Erk1/2	MITF	5595;5594	4286	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Hesperidin , A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation .
18434324	0	Erk1/2	103,109	MKP-1	133,138	Erk1/2	MKP-1	5595;5594	1843	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Phosphorylation of protein_kinase_Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1 : role in the apoptotic effect of etoposide .
22550139	0	Erk1/2	16,22	MMP-2	0,5	Erk1/2	MMP-2	26417;26413	17390(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	MMP-2 regulates Erk1/2 phosphorylation and aortic_dilatation in Marfan_syndrome .
22056560	0	Erk1/2	24,30	Osterix	0,7	Erk1/2	Osterix	5595;5594	121340	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Osterix is regulated by Erk1/2 during osteoblast differentiation .
11222647	0	Erk1/2	89,95	PI-3K	45,50	Erk1/2	PI-3K	50689;116590	298947(Tax:10116)	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Activation of phosphatidylinositol-3 kinase -LRB- PI-3K -RRB- and extracellular regulated kinases -LRB- Erk1/2 -RRB- is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells .
24269630	0	Erk1/2	15,21	PP2A	103,107	Erk1/2	PP2A	5595;5594	5524	Gene	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2 + - CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells .
15141098	0	Erk1/2	0,6	Raf-1	88,93	Erk1/2	Raf-1	50689;116590	24703(Tax:10116)	Gene	Gene	crosstalk|dep|START_ENTITY crosstalk|compound|END_ENTITY	Erk1/2 phosphorylation and reactive_oxygen_species formation via nitric_oxide and Akt-1 / Raf-1 crosstalk in cultured rat cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane .
16514107	0	Erk1/2	109,115	Reelin	0,6	Erk1/2	Reelin	50689;116590	24718(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation .
24876378	0	Erk1/2	15,21	Reelin	0,6	Erk1/2	Reelin	5595;5594	5649	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway .
19524687	0	Erk1/2	102,108	STAT3	125,130	Erk1/2	STAT3	5595;5594	6774	Gene	Gene	Akt|compound|START_ENTITY activation|nmod|Akt downregulating|dobj|activation downregulating|nmod|END_ENTITY	Restoration of SOCS3 suppresses human lung_adenocarcinoma cell growth by downregulating activation of Erk1/2 , Akt apart from STAT3 .
25174327	0	Erk1/2	0,6	STAT3	36,41	Erk1/2	STAT3	5595;5594	6774	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Erk1/2 activation and modulation of STAT3 signaling in oral_cancer .
15067346	0	Erk1/2	15,21	Smad2	0,5	Erk1/2	Smad2	5595;5594	4087	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended , but not in adherent , gastric_carcinoma cells .
23205673	0	Erk1/2	97,103	Stat3	35,40	Erk1/2	Stat3	26417;26413	20848(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY suppresses|dobj|activation suppresses|nsubj|END_ENTITY	Leukemia_inhibitory_factor-induced Stat3 signaling suppresses fibroblast_growth_factor_1-induced Erk1/2 activation to inhibit the downstream differentiation in mouse embryonic stem cells .
25120769	0	Erk1/2	49,55	aquaporin_8	14,25	Erk1/2	aquaporin 8	5595;5594	343	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin_8 and phosphorylation of Erk1/2 in cervical epithelial carcinogenesis : correlation with clinicopathological parameters .
17074804	0	Erk1/2	143,149	epidermal_growth_factor_receptor	50,82	Erk1/2	epidermal growth factor receptor	5595	1956	Gene	Gene	kinase|amod|START_ENTITY transactivation|nmod|kinase transactivation|compound|END_ENTITY	Progesterone_receptors upregulate Wnt-1 to induce epidermal_growth_factor_receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast_cancer cells .
22076135	0	Erk1/2	0,6	leptin_receptor	16,31	Erk1/2	leptin receptor	50689;116590	24536(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Erk1/2 mediates leptin_receptor signaling in the ventral tegmental area .
26876787	0	Erk1/2	39,45	mitogen-activated_protein_kinase-activated_protein_kinase_2	48,107	Erk1/2	mitogen-activated protein kinase-activated protein kinase 2	5595;5594	9261	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Extracellular-signal regulated kinase -LRB- Erk1/2 -RRB- , mitogen-activated_protein_kinase-activated_protein_kinase_2 -LRB- MK2 -RRB- and tristetraprolin -LRB- TTP -RRB- comprehensively regulate injury-induced immediate early gene -LRB- IEG -RRB- response in in vitro liver organ culture .
15240007	0	Erk1/2	34,40	oncostatin_M	98,110	Erk1/2	oncostatin M	26417;26413	18413(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin_M in murine fibroblasts .
12220517	0	Erk2	37,41	Sp1	12,15	Erk2	Sp1	26413(Tax:10090)	20683(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of Sp1 in BMP2-up-regulated Erk2 gene expression .
20185831	0	Erk5	47,51	peroxisome_proliferator-activated_receptor_gamma	66,114	Erk5	peroxisome proliferator-activated receptor gamma	23939(Tax:10090)	19016(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- .
18809725	0	Ero1L	0,5	Notch	40,45	Ero1L	Notch	38500(Tax:7227)	31293(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Ero1L , a thiol oxidase , is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila_melanogaster .
20562109	0	Ero1alpha	0,9	protein-disulfide_isomerase	62,89	Ero1alpha	protein-disulfide isomerase	30001	64714	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Ero1alpha is expressed on blood platelets in association with protein-disulfide_isomerase and contributes to redox-controlled remodeling of alphaIIbbeta3 .
16181637	0	Erv1	36,40	Mia40	57,62	Erv1	Mia40	852916(Tax:4932)	853639(Tax:4932)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins .
20367271	0	Erv1	120,124	Mia40	66,71	Erv1	Mia40	852916(Tax:4932)	853639(Tax:4932)	Gene	Gene	core|amod|START_ENTITY determines|nmod|core determines|dobj|transfer transfer|amod|affinity affinity|nmod|END_ENTITY	The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria .
20367271	0	Erv1	33,37	Mia40	66,71	Erv1	Mia40	852916(Tax:4932)	853639(Tax:4932)	Gene	Gene	domain|nmod|START_ENTITY determines|nsubj|domain determines|dobj|transfer transfer|amod|affinity affinity|nmod|END_ENTITY	The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria .
22712502	0	Erythroid_differentiation-associated_gene	0,41	NPM1	57,61	Erythroid differentiation-associated gene	NPM1	55363	4869	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Erythroid_differentiation-associated_gene interacts with NPM1 -LRB- nucleophosmin/B23 -RRB- and increases its protein stability , resisting cell apoptosis .
23920063	0	Erythropoietin	0,14	ACE	29,32	Erythropoietin	ACE	24335(Tax:10116)	24310(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Erythropoietin combined with ACE inhibitor prevents heart remodeling in 5/6 nephrectomized rats independently of blood pressure and kidney function .
26643367	0	Erythropoietin	0,14	AKT	73,76	Erythropoietin	AKT	13856(Tax:10090)	11651(Tax:10090)	Gene	Gene	alleviates|nsubj|START_ENTITY alleviates|dobj|resistance resistance|nmod|activation activation|compound|END_ENTITY	Erythropoietin alleviates hepatic insulin resistance via PPARy-dependent AKT activation .
7601253	0	Erythropoietin	0,14	AP1	29,32	Erythropoietin	AP1	2056	2353	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Erythropoietin activation of AP1 -LRB- Fos/Jun -RRB- .
17217721	0	Erythropoietin	1,15	Akt	151,154	Erythropoietin	Akt	24335(Tax:10116)	24185(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|model model|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Erythropoietin enhances the therapy potency of autologous bone marrow stromal cells in a rat heart_infarction model via phosphatidylinositol-3-kinase / Akt pathway -RSB- .
20456444	0	Erythropoietin	0,14	CD44	27,31	Erythropoietin	CD44	2056	960	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Erythropoietin and soluble CD44 levels in patients with primary_open-angle_glaucoma .
7993659	0	Erythropoietin	0,14	EPO	16,19	Erythropoietin	EPO	24335(Tax:10116)	24335(Tax:10116)	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Erythropoietin -LRB- EPO -RRB- levels in fetal rats after ritodrine and terbutaline administration .
17161437	0	Erythropoietin	0,14	EPO-receptor	22,34	Erythropoietin	EPO-receptor	13856(Tax:10090)	13857(Tax:10090)	Gene	Gene	START_ENTITY|dep|signaling signaling|compound|END_ENTITY	Erythropoietin -LRB- EPO -RRB- : EPO-receptor signaling improves early endochondral ossification and mechanical strength in fracture healing .
23821361	0	Erythropoietin	0,14	EPO_receptor	105,117	Erythropoietin	EPO receptor	24335(Tax:10116)	24336(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Erythropoietin -LRB- EPO -RRB- increases myelin gene expression in CG4 oligodendrocyte cells through the classical EPO_receptor .
10194437	0	Erythropoietin	0,14	GAB1	55,59	Erythropoietin	GAB1	2056	2549	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC , SHP2 , SHIP , and phosphatidylinositol 3-kinase .
16204311	0	Erythropoietin	0,14	GATA-1	60,66	Erythropoietin	GATA-1	2056	2623	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway .
24323731	0	Erythropoietin	0,14	HIF-1a	24,30	Erythropoietin	HIF-1a	24335(Tax:10116)	29560(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Erythropoietin inhibits HIF-1a expression via upregulation of PHD-2 transcription and translation in an in vitro model of hypoxia-ischemia .
21620963	0	Erythropoietin	0,14	JAK2	144,148	Erythropoietin	JAK2	2056	3717	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|cells cells|dep|role role|nmod|PI3K PI3K|compound|END_ENTITY	Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions : essential role of JAK2 / PI3K signaling .
24004818	0	Erythropoietin	0,14	JAK2	20,24	Erythropoietin	JAK2	2056	3717	Gene	Gene	effector|nsubj|START_ENTITY effector|compound|END_ENTITY	Erythropoietin is a JAK2 and ERK1/2 effector that can promote renal_tumor cell proliferation under hypoxic conditions .
8068943	0	Erythropoietin	0,14	JAK2	42,46	Erythropoietin	JAK2	2056	3717	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|kinase kinase|compound|END_ENTITY	Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo .
9657743	0	Erythropoietin	0,14	Jak2	51,55	Erythropoietin	Jak2	2056	3717	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin induces tyrosine phosphorylation of Jak2 , STAT5A , and STAT5B in primary cultured human erythroid precursors .
24395206	0	Erythropoietin	0,14	NDPKA	34,39	Erythropoietin	NDPKA	2056	4830	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Erythropoietin increases neuronal NDPKA expression , and NDPKA up-regulation as well as exogenous application protects cortical neurons from in vitro ischemia-related insults .
16375720	0	Erythropoietin	0,14	NF-kappaB	24,33	Erythropoietin	NF-kappaB	2056	4790	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal_injury during beta-amyloid toxicity .
20229611	0	Erythropoietin	0,14	Nrf2	48,52	Erythropoietin	Nrf2	2056	4780	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Erythropoietin induces nuclear translocation of Nrf2 and heme_oxygenase-1 expression in SH-SY5Y cells .
26563310	0	Erythropoietin	0,14	POMC	25,29	Erythropoietin	POMC	13856(Tax:10090)	18976(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response .
8978277	0	Erythropoietin	0,14	Raf1	25,29	Erythropoietin	Raf1	13856(Tax:10090)	110157(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells .
26563310	0	Erythropoietin	0,14	STAT3	45,50	Erythropoietin	STAT3	13856(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response .
16982325	0	Erythropoietin	0,14	STAT5	52,57	Erythropoietin	STAT5	13856(Tax:10090)	20850(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin induces sustained phosphorylation of STAT5 in primitive but not definitive erythrocytes generated from mouse embryonic stem cells .
8400282	0	Erythropoietin	0,14	Shc	58,61	Erythropoietin	Shc	13856(Tax:10090)	20416(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein .
10428780	0	Erythropoietin	0,14	Stat5	61,66	Erythropoietin	Stat5	2056	6776	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|END_ENTITY	Erythropoietin can induce the expression of bcl-x -LRB- L -RRB- through Stat5 in erythropoietin-dependent progenitor cell lines .
11152572	0	Erythropoietin	0,14	Stat5	45,50	Erythropoietin	Stat5	2056	6776	Gene	Gene	receptors|compound|START_ENTITY receptors|acl:relcl|signal signal|nmod|END_ENTITY	Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis : lack of specificity of stat signals during red blood cell development .
8657137	0	Erythropoietin	0,14	Stat5	37,42	Erythropoietin	Stat5	2056	6776	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response .
7744799	0	Erythropoietin	0,14	TAL1/SCL	47,55	Erythropoietin	TAL1/SCL	13856(Tax:10090)	21349(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Erythropoietin stimulates transcription of the TAL1/SCL gene and phosphorylation of its protein products .
12167663	0	Erythropoietin	0,14	TRPC2	48,53	Erythropoietin	TRPC2	13856(Tax:10090)	22064(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Erythropoietin modulates calcium influx through TRPC2 .
26376749	0	Erythropoietin	41,55	Tumor_Necrosis_Factor-Alpha	10,37	Erythropoietin	Tumor Necrosis Factor-Alpha	2056	7124	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Tumor_Necrosis_Factor-Alpha on Erythropoietin and Erythropoietin Receptor-Induced Erythroid Progenitor Cell Proliferation in b-Thalassemia/Hemoglobin E Patients .
11239021	0	Erythropoietin	0,14	angiotensin_II	25,39	Erythropoietin	angiotensin II	24335(Tax:10116)	24179(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|mobilization mobilization|amod|END_ENTITY	Erythropoietin modulates angiotensin_II - or noradrenaline-induced Ca -LRB- 2 + -RRB- mobilization in cultured rat vascular smooth-muscle cells .
19100095	0	Erythropoietin	1,15	angiotensin_II	107,121	Erythropoietin	angiotensin II	24335(Tax:10116)	24179(Tax:10116)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|fibroblasts fibroblasts|acl|induced induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Erythropoietin suppresses the expressions of TGF-beta1 and collagen in rat cardiac fibroblasts induced by angiotensin_II -RSB- .
19781221	0	Erythropoietin	1,15	angiotensin_II	25,39	Erythropoietin	angiotensin II	24335(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	-LSB- Erythropoietin inhibits angiotensin_II induced cardiomyocyte hypertrophy in vitro via activating PI3K/Akt-eNOS pathway -RSB- .
8786548	0	Erythropoietin	0,14	atrial_natriuretic_peptide	26,52	Erythropoietin	atrial natriuretic peptide	24335(Tax:10116)	24602(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Erythropoietin stimulates atrial_natriuretic_peptide secretion from adult rat cardiac atrium .
16319448	0	Erythropoietin	0,14	bax	29,32	Erythropoietin	bax	24335(Tax:10116)	24887(Tax:10116)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Erythropoietin downregulates bax and DP5 proapoptotic gene expression in neonatal hypoxic-ischemic_brain_injury .
8599971	0	Erythropoietin	0,14	eIF-4E	45,51	Erythropoietin	eIF-4E	13856(Tax:10090)	13684(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin stimulates phosphorylation of eIF-4E and identification of a 37-kD phosphoprotein that binds mRNA caps in erythroblasts .
15456912	0	Erythropoietin	0,14	erythropoietin	53,67	Erythropoietin	erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor .
18218911	0	Erythropoietin	0,14	erythropoietin	122,136	Erythropoietin	erythropoietin	2056	2056	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle .
25266611	0	Erythropoietin	0,14	erythropoietin	33,47	Erythropoietin	erythropoietin	2056	2056	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Erythropoietin : emerging role of erythropoietin in neonatal neuroprotection .
7084423	0	Erythropoietin	0,14	erythropoietin	80,94	Erythropoietin	erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	formation|compound|START_ENTITY formation|nmod|END_ENTITY	Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection .
8068943	0	Erythropoietin	0,14	erythropoietin	80,94	Erythropoietin	erythropoietin	2056	2056	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|receptor receptor|compound|END_ENTITY	Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo .
22411849	0	Erythropoietin	0,14	frataxin	50,58	Erythropoietin	frataxin	2056	2395	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Erythropoietin in Friedreich_ataxia : no effect on frataxin in a randomized controlled trial .
10561191	0	Erythropoietin	0,14	granulocyte_colony-stimulating_factor	27,64	Erythropoietin	granulocyte colony-stimulating factor	2056	1440	Gene	Gene	addition|compound|START_ENTITY addition|nmod|abrogates abrogates|amod|END_ENTITY	Erythropoietin addition to granulocyte_colony-stimulating_factor abrogates life-threatening neutropenia and increases peripheral-blood progenitor-cell mobilization after epirubicin , paclitaxel , and cisplatin combination chemotherapy : results of a randomized comparison .
25806072	0	Erythropoietin	0,14	growth_associated_protein-43	27,55	Erythropoietin	growth associated protein-43	24335(Tax:10116)	29423(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Erythropoietin upregulates growth_associated_protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush .
17560935	0	Erythropoietin	0,14	heme_oxygenase-1	23,39	Erythropoietin	heme oxygenase-1	24335(Tax:10116)	24451(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Erythropoietin induces heme_oxygenase-1 expression and attenuates oxidative stress .
9334184	0	Erythropoietin	0,14	insulin_receptor_substrate-2	55,83	Erythropoietin	insulin receptor substrate-2	2056	8660	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of insulin_receptor_substrate-2 .
21898543	0	Erythropoietin	0,14	mTOR	55,59	Erythropoietin	mTOR	13856(Tax:10090)	21977(Tax:10090)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|regulated regulated|nmod|END_ENTITY	Erythropoietin mediated bone formation is regulated by mTOR signaling .
22023617	0	Erythropoietin	0,14	mTOR	43,47	Erythropoietin	mTOR	2056	21977(Tax:10090)	Gene	Gene	govern|nsubj|START_ENTITY govern|dobj|pathways pathways|nmod|END_ENTITY	Erythropoietin and Wnt1 govern pathways of mTOR , Apaf-1 , and XIAP in inflammatory microglia .
8527301	0	Erythropoietin	0,14	p70S6k	46,52	Erythropoietin	p70S6k	13856(Tax:10090)	72508(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Erythropoietin induces biphasic activation of p70S6k : evidence for a different regulation of early and late phase of activation .
8034732	0	Erythropoietin	0,14	phospholipase_C-gamma_1	66,89	Erythropoietin	phospholipase C-gamma 1	2056	5335	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Erythropoietin induces tyrosine phosphorylation and activation of phospholipase_C-gamma_1 in a human erythropoietin-dependent cell line .
9573541	0	Erythropoietin	0,14	phospholipase_C-gamma_1	62,85	Erythropoietin	phospholipase C-gamma 1	2056	5335	Gene	Gene	channels|amod|START_ENTITY channels|dep|activation activation|nmod|END_ENTITY	Erythropoietin receptor-operated Ca2 + channels : activation by phospholipase_C-gamma_1 .
19492092	0	Erythropoietin	0,14	stem_cell_factor	30,46	Erythropoietin	stem cell factor	13856(Tax:10090)	17311(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Erythropoietin down-regulates stem_cell_factor receptor -LRB- Kit -RRB- expression in the leukemic proerythroblast : role of Lyn kinase .
20671252	0	Erythropoietin	0,14	tissue_plasminogen_activator	33,61	Erythropoietin	tissue plasminogen activator	24335(Tax:10116)	25692(Tax:10116)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Erythropoietin in combination of tissue_plasminogen_activator exacerbates brain_hemorrhage when treatment is initiated 6 hours after stroke .
14746681	0	Erythropoietin	1,15	transferrin_receptor	26,46	Erythropoietin	transferrin receptor	2056	7037	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	-LSB- Erythropoietin increases transferrin_receptor expression and the impact of erythropoietin on K562 leukemic cell cycle -RSB- .
19061883	0	Erythropoietin	0,14	tumor_necrosis_factor-alpha	81,108	Erythropoietin	tumor necrosis factor-alpha	2056	7124	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|ischemia-reperfusion ischemia-reperfusion|acl|induced induced|advcl|inhibiting inhibiting|dobj|expression expression|amod|END_ENTITY	Erythropoietin attenuates ischemia-reperfusion induced lung_injury by inhibiting tumor_necrosis_factor-alpha and matrix_metalloproteinase-9 expression .
19631208	0	Erythropoietin	0,14	tumor_necrosis_factor-alpha	88,115	Erythropoietin	tumor necrosis factor-alpha	2056	7124	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|cytotoxicity cytotoxicity|nmod|END_ENTITY	Erythropoietin protects myocardin-expressing cardiac stem cells against cytotoxicity of tumor_necrosis_factor-alpha .
2338132	0	Erythropoietin	0,14	tumor_necrosis_factor-alpha	75,102	Erythropoietin	tumor necrosis factor-alpha	13856(Tax:10090)	21926(Tax:10090)	Gene	Gene	fails|nsubj|START_ENTITY fails|xcomp|reverse reverse|nmod|mice mice|acl|exposed exposed|nmod|END_ENTITY	Erythropoietin fails to reverse the anemia in mice continuously exposed to tumor_necrosis_factor-alpha in vivo .
22707988	0	Erythropoietin	0,14	vascular_endothelial_growth_factor	147,181	Erythropoietin	vascular endothelial growth factor	24335(Tax:10116)	83785(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|expression expression|nmod|END_ENTITY	Erythropoietin mediates neurobehavioral recovery and neurovascular remodeling following traumatic_brain_injury in rats by increasing expression of vascular_endothelial_growth_factor .
8507186	0	Erythropoietin_receptor	0,23	gp55	46,50	Erythropoietin receptor	gp55	2057	27020	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Erythropoietin_receptor binds to Friend virus gp55 through other membrane components .
1765383	0	Es-10	61,66	Htr-2	34,39	Es-10	Htr-2	13885(Tax:10090)	15558(Tax:10090)	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10 on mouse chromosome 14 .
14988729	0	Esc4p	0,5	Mec1p	23,28	Esc4p	Mec1p	856559(Tax:4932)	852433(Tax:4932)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Esc4p , a new target of Mec1p -LRB- ATR -RRB- , promotes resumption of DNA synthesis after DNA damage .
26434741	0	Esco2	0,5	cx43	16,20	Esco2	cx43	445395(Tax:7955)	30236(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Esco2 regulates cx43 expression during skeletal regeneration in the zebrafish fin .
18824154	0	Esophageal_Cancer-Related_Gene_2	53,85	uPA	38,41	Esophageal Cancer-Related Gene 2	uPA	84651	5328	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Mapping the putative binding site for uPA protein in Esophageal_Cancer-Related_Gene_2 by heteronuclear NMR method .
10087294	0	Esp	38,41	osteotesticular_phosphatase	4,31	Esp	osteotesticular phosphatase	64576(Tax:10116)	64576(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Rat osteotesticular_phosphatase gene -LRB- Esp -RRB- : genomic structure and chromosome location .
23040477	0	Esrrb	0,5	Nanog	18,23	Esrrb	Nanog	2103	79923	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells .
23019124	0	Esrrb	32,37	Ncoa3	0,5	Esrrb	Ncoa3	2103	8202	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming .
18957414	0	Esrrb	0,5	Oct4	16,20	Esrrb	Oct4	26380(Tax:10090)	100846986	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells .
7183436	0	Estramustine_binding_protein	12,40	EBP	42,45	Estramustine binding protein	EBP	117278(Tax:10116)	117278(Tax:10116)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of Estramustine_binding_protein -LRB- EBP -RRB- in rat dorsal prostate by means of high pressure liquid chromatography .
16267049	0	Estrogen-related_receptor_alpha	0,31	phosphoenolpyruvate_carboxykinase	50,83	Estrogen-related receptor alpha	phosphoenolpyruvate carboxykinase	2101	5106	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|transcription transcription|amod|END_ENTITY	Estrogen-related_receptor_alpha is a repressor of phosphoenolpyruvate_carboxykinase gene transcription .
19429439	0	Estrogen-related_receptor_alpha	0,31	vascular_endothelial_growth_factor	58,92	Estrogen-related receptor alpha	vascular endothelial growth factor	2101	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Estrogen-related_receptor_alpha induces the expression of vascular_endothelial_growth_factor in breast_cancer cells .
17765677	0	Estrogen-related_receptor_beta	0,30	NR3B2	31,36	Estrogen-related receptor beta	NR3B2	2103	2103	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	Estrogen-related_receptor_beta / NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis .
18662995	0	Estrogen-related_receptor_beta	0,30	Oct4	46,50	Estrogen-related receptor beta	Oct4	2103	5460	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Estrogen-related_receptor_beta interacts with Oct4 to positively regulate Nanog gene expression .
21847390	0	Estrogen_Receptor-a	8,27	Claudin-6	49,58	Estrogen Receptor-a	Claudin-6	2099	9074	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Regulation Regulation|nmod|Expression Expression|compound|END_ENTITY	Role of Estrogen_Receptor-a in the Regulation of Claudin-6 Expression in Breast_Cancer Cells .
17446729	0	Estrogen_Receptor_1	0,19	ESR1	26,30	Estrogen Receptor 1	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Estrogen_Receptor_1 gene -LRB- ESR1 -RRB- variants in Alzheimer 's _ disease .
25979954	0	Estrogen_Receptor_1	36,55	ESR1	57,61	Estrogen Receptor 1	ESR1	2099	2099	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Noninvasive Detection of Activating Estrogen_Receptor_1 -LRB- ESR1 -RRB- Mutations in Estrogen Receptor-Positive Metastatic Breast_Cancer .
21080949	0	Estrogen_Receptor_Beta	32,54	ESR2	56,60	Estrogen Receptor Beta	ESR2	2100	2100	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Common genetic variation in the Estrogen_Receptor_Beta -LRB- ESR2 -RRB- gene and osteoarthritis : results of a meta-analysis .
26147849	0	Estrogen_Receptor_ERb	11,32	ESR2	34,38	Estrogen Receptor ERb	ESR2	25149(Tax:10116)	25149(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Changes in Estrogen_Receptor_ERb -LRB- ESR2 -RRB- Expression without Changes in the Estradiol Levels in the Prostate of Aging Rats .
24723976	0	Estrogen_Receptor_a	135,154	Transforming_Growth_Factor-b	92,120	Estrogen Receptor a	Transforming Growth Factor-b	2099	7040	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Identification of a Novel Compound That Suppresses Breast_Cancer Invasiveness by Inhibiting Transforming_Growth_Factor-b Signaling via Estrogen_Receptor_a .
26700939	0	Estrogen_Receptor_b	0,19	MMP-19	29,35	Estrogen Receptor b	MMP-19	13983(Tax:10090)	58223(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	Estrogen_Receptor_b controls MMP-19 expression in mouse ovaries during ovulation .
16971528	0	Estrogen_receptor	0,17	Akt	111,114	Estrogen receptor	Akt	2099	207	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Estrogen_receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular_signal-regulated_kinase_1 / 2 in the same population of cortical neurons : a unified mechanism of estrogen action .
20215421	0	Estrogen_receptor	0,17	E2F1	28,32	Estrogen receptor	E2F1	2099	1869	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Estrogen_receptor regulates E2F1 expression to mediate tamoxifen resistance .
11061547	0	Estrogen_receptor	0,17	ERbeta	24,30	Estrogen receptor	ERbeta	2099	2100	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Estrogen_receptor beta -LRB- ERbeta -RRB- messenger ribonucleic acid -LRB- mRNA -RRB- expression within the human forebrain : distinct distribution pattern to ERalpha mRNA .
12746293	0	Estrogen_receptor	0,17	Sp1	18,21	Estrogen receptor	Sp1	2099	6667	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|complexes complexes|amod|END_ENTITY	Estrogen_receptor / Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast_cancer cells .
1356959	0	Estrogen_receptor	0,17	c-erbB-2	19,27	Estrogen receptor	c-erbB-2	2099	2064	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Estrogen_receptor , c-erbB-2 and nm23/NDP kinase expression in the intraductal and invasive components of human breast_cancers .
16043358	0	Estrogen_receptor	0,17	interleukin-6	27,40	Estrogen receptor	interleukin-6	2099	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Estrogen_receptor inhibits interleukin-6 gene expression by disruption of nuclear factor kappaB transactivation .
23000059	0	Estrogen_receptor	0,17	mTORC2	30,36	Estrogen receptor	mTORC2	2099	74343(Tax:10090)	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	Estrogen_receptor potentiates mTORC2 signaling in breast_cancer cells by upregulating superoxide anions .
20080630	0	Estrogen_receptor	0,17	p53	105,108	Estrogen receptor	p53	2099	7157	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|sequences sequences|compound|END_ENTITY	Estrogen_receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences .
20080630	0	Estrogen_receptor	0,17	p53	55,58	Estrogen receptor	p53	2099	7157	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|transactivation transactivation|compound|END_ENTITY	Estrogen_receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences .
16055089	0	Estrogen_receptor-alpha	0,23	SOCS-3	34,40	Estrogen receptor-alpha	SOCS-3	2099	9021	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Estrogen_receptor-alpha regulates SOCS-3 expression in human breast_cancer cells .
24371584	0	Estrogen_receptor-alpha	0,23	Toll-like_receptor-2	33,53	Estrogen receptor-alpha	Toll-like receptor-2	2099	7097	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Estrogen_receptor-alpha mediates Toll-like_receptor-2 agonist-induced monocyte_chemoattractant_protein-1 production in mesangial cells .
15763593	0	Estrogen_receptor-alpha	0,23	bcl-2	25,30	Estrogen receptor-alpha	bcl-2	2099	596	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Estrogen_receptor-alpha , bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast : association with nodule size , hormonal and reproductive features .
16469747	0	Estrogen_receptor-alpha	0,23	p53	30,33	Estrogen receptor-alpha	p53	2099	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|protein protein|compound|END_ENTITY	Estrogen_receptor-alpha binds p53 tumor suppressor protein directly and represses its function .
20375995	0	Estrogen_receptor_1	0,19	ESR1	26,30	Estrogen receptor 1	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Estrogen_receptor_1 gene -LRB- ESR1 -RRB- is associated with restrictive_anorexia_nervosa .
23857602	0	Estrogen_receptor_a	0,19	ATM	30,33	Estrogen receptor a	ATM	2099	472	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|Expression Expression|compound|END_ENTITY	Estrogen_receptor_a regulates ATM Expression through miRNAs in breast_cancer .
23116284	0	Estrogen_receptor_a	0,19	ESR1	26,30	Estrogen receptor a	ESR1	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Estrogen_receptor_a gene -LRB- ESR1 -RRB- polymorphisms associated with idiopathic premature_ovarian_failure in Chinese women .
24449583	0	Estrogen_receptor_a	0,19	tripartite_motif-containing_protein_21	30,68	Estrogen receptor a	tripartite motif-containing protein 21	2099	6737	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estrogen_receptor_a regulates tripartite_motif-containing_protein_21 expression , contributing to dysregulated cytokine production in systemic_lupus_erythematosus .
16010691	0	Estrogen_receptor_alpha	0,23	CYP1A1	90,96	Estrogen receptor alpha	CYP1A1	2099	1543	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Estrogen_receptor_alpha increases basal and cigarette_smoke_extract-induced expression of CYP1A1 and CYP1B1 , but not GSTP1 , in normal human bronchial epithelial cells .
16601072	0	Estrogen_receptor_alpha	0,23	Galpha13	39,47	Estrogen receptor alpha	Galpha13	2099	10672	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Estrogen_receptor_alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway .
22375075	0	Estrogen_receptor_alpha	0,23	HADHB	61,66	Estrogen receptor alpha	HADHB	2099	3032	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Estrogen_receptor_alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity .
10749889	0	Estrogen_receptor_alpha	0,23	IGF-1_receptor	46,60	Estrogen receptor alpha	IGF-1 receptor	2099	3480	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Estrogen_receptor_alpha rapidly activates the IGF-1_receptor pathway .
12072388	0	Estrogen_receptor_alpha	0,23	IL-1beta	33,41	Estrogen receptor alpha	IL-1beta	13982(Tax:10090)	16176(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|compound|END_ENTITY	Estrogen_receptor_alpha inhibits IL-1beta induction of gene expression in the mouse liver .
12706304	0	Estrogen_receptor_alpha	0,23	progesterone_receptor	41,62	Estrogen receptor alpha	progesterone receptor	2099	5241	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Estrogen_receptor_alpha and Sp1 regulate progesterone_receptor gene expression .
16916954	0	Estrogen_related_receptor-alpha	0,31	surfactant_protein-A	41,61	Estrogen related receptor-alpha	surfactant protein-A	2101	653509	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Estrogen_related_receptor-alpha enhances surfactant_protein-A gene expression in fetal lung type II cells .
20373895	0	Et-1	28,32	VEGF	71,75	Et-1	VEGF	1906	7422	Gene	Gene	START_ENTITY|appos|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Aqueous_humor_endothelin-1 -LRB- Et-1 -RRB- , vascular_endothelial_growth_factor -LRB- VEGF -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- levels in Mexican glaucomatous patients .
2351930	0	Eta-1	82,87	early_T_lymphocyte_activation_1	49,80	Eta-1	early T lymphocyte activation 1	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Definition of a specific interaction between the early_T_lymphocyte_activation_1 -LRB- Eta-1 -RRB- protein and murine macrophages in vitro and its effect upon macrophages in vivo .
2787378	0	Eta-1	74,79	early_T_lymphocyte_activation_1	41,72	Eta-1	early T lymphocyte activation 1	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural and functional studies of the early_T_lymphocyte_activation_1 -LRB- Eta-1 -RRB- gene .
12465727	0	Eta-1	27,32	osteopontin	14,25	Eta-1	osteopontin	6696	6696	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of osteopontin -LRB- Eta-1 -RRB- in Crohn_disease of the terminal ileum .
24645853	0	Ethylene_Response_Factor	37,61	ERF	63,66	Ethylene Response Factor	ERF	606712(Tax:4081)	606712(Tax:4081)	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	The chimeric repressor version of an Ethylene_Response_Factor -LRB- ERF -RRB- family member , Sl-ERF .
25723847	0	Ethylene_response_factor_3	17,43	ERF3	45,49	Ethylene response factor 3	ERF3	102580681	102580681	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	The induction of Ethylene_response_factor_3 -LRB- ERF3 -RRB- in potato as a result of co-inoculation with Pseudomonas sp .
20722567	0	Ets-1	29,34	Ang_II	0,6	Ets-1	Ang II	23871(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Ang_II enhances tubular cell Ets-1 expression and associated down stream signaling is mediated through AT1 receptors .
15541767	0	Ets-1	47,52	COUP-TFII	18,27	Ets-1	COUP-TFII	23871(Tax:10090)	11819(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The regulation of COUP-TFII gene expression by Ets-1 is enhanced by the steroid receptor co-activators .
7935445	0	Ets-1	0,5	DRA	20,23	Ets-1	DRA	2113	1811	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Ets-1 activates the DRA promoter in B cells .
18948081	0	Ets-1	25,30	Epiregulin	0,10	Ets-1	Epiregulin	2113	2069	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Epiregulin expression by Ets-1 and ERK signaling pathway in Ki-ras-transformed cells .
9867825	0	Ets-1	79,84	FREAC-4	55,62	Ets-1	FREAC-4	2113	2297	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The kidney-expressed winged helix transcription factor FREAC-4 is regulated by Ets-1 .
11970950	0	Ets-1	0,5	Fas_ligand	27,37	Ets-1	Fas ligand	2113	356	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Ets-1 positively regulates Fas_ligand transcription via cooperative interactions with Sp1 .
20574810	0	Ets-1	32,37	Foxp3	58,63	Ets-1	Foxp3	2113	50943	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Methylation matters : binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells .
10438459	0	Ets-1	57,62	GnT-V	18,23	Ets-1	GnT-V	2113	4249	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Regulation of the GnT-V promoter by transcription factor Ets-1 in various cancer cell lines .
23924923	0	Ets-1	92,97	IL-8	68,72	Ets-1	IL-8	2113	3576	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric_cancer cells .
24185710	0	Ets-1	62,67	Ia1	21,24	Ets-1	Ia1	2113	3642	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Activation of the Ig Ia1 promoter by the transcription factor Ets-1 triggers Ig Ia1-Ca1 germline transcription in epithelial cancer cells .
18851945	0	Ets-1	0,5	MMP-1	31,36	Ets-1	MMP-1	2113	4312	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Ets-1 upregulates HER2-induced MMP-1 expression in breast_cancer cells .
22546552	0	Ets-1	77,82	ORMDL3	21,27	Ets-1	ORMDL3	2113	94103	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Mechanisms elevating ORMDL3 expression in recurrent wheeze patients : role of Ets-1 , p300 and CREB .
19616560	0	Ets-1	34,39	Pax5	73,77	Ets-1	Pax5	2113	5079	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5 .
11970950	0	Ets-1	0,5	Sp1	86,89	Ets-1	Sp1	2113	6667	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ets-1 positively regulates Fas_ligand transcription via cooperative interactions with Sp1 .
16157598	0	Ets-1	27,32	Sp1	0,3	Ets-1	Sp1	23871(Tax:10090)	20683(Tax:10090)	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	Sp1 is a co-activator with Ets-1 , and Net is an important repressor of the transcription of CTP : phosphocholine_cytidylyltransferase_alpha .
23552426	0	Ets-1	0,5	VEGFR3	40,46	Ets-1	VEGFR3	2113	2324	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Ets-1 is required for the activation of VEGFR3 during latent Kaposi 's _ sarcoma-associated_herpesvirus_infection of endothelial cells .
22829018	0	Ets-1	47,52	collagen	81,89	Ets-1	collagen	2113	1278	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Inhibitory effects of the transcription factor Ets-1 on the expression of type I collagen in TGF-b1-stimulated renal epithelial cells .
22539964	0	Ets-1	0,5	connective_tissue_growth_factor	23,54	Ets-1	connective tissue growth factor	2113	1490	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Ets-1 is essential for connective_tissue_growth_factor -LRB- CTGF/CCN2 -RRB- induction by TGF-b1 in osteoblasts .
11991951	0	Ets-1	0,5	fli-1	16,21	Ets-1	fli-1	23871(Tax:10090)	14247(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Ets-1 regulates fli-1 expression in endothelial cells .
12039986	0	Ets-1	21,26	gelatinase_a	37,49	Ets-1	gelatinase a	2113	81686(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Transcription factor Ets-1 regulates gelatinase_a gene expression in mesangial cells .
15555331	0	Ets-1	88,93	latent_membrane_protein_1	18,43	Ets-1	latent membrane protein 1	2113	9260	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- EB virus encoded latent_membrane_protein_1 mediated expression of transcription factor Ets-1 in nasopharyngeal_carcinoma cells -RSB- .
14734780	0	Ets-1	0,5	matrix_metalloproteinase-9	34,60	Ets-1	matrix metalloproteinase-9	2113	4318	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Ets-1 regulates TNF-alpha-induced matrix_metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts .
21081489	0	Ets-1	17,22	miR-200b	0,8	Ets-1	miR-200b	2113	406984	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells .
25893733	0	Ets-1	67,72	p21	73,76	Ets-1	p21	2113	644914	Gene	Gene	apoptosis|nmod|START_ENTITY END_ENTITY|dep|apoptosis	MicroRNA-221 / 222 regulate ox-LDL-induced endothelial apoptosis via Ets-1 / p21 inhibition .
12850290	0	Ets-1	0,5	parathyroid_hormone-related_protein	16,51	Ets-1	parathyroid hormone-related protein	2113	5744	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Ets-1 activates parathyroid_hormone-related_protein gene expression in tumorigenic breast epithelial cells .
10218628	0	Ets-1	0,5	urokinase-type_plasminogen_activator	41,77	Ets-1	urokinase-type plasminogen activator	2113	5328	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Ets-1 positively regulates expression of urokinase-type_plasminogen_activator -LRB- uPA -RRB- and invasiveness of astrocytic_tumors .
12894593	0	Ets-2	0,5	BS69	34,38	Ets-2	BS69	2114	10771	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ets-2 interacts with co-repressor BS69 to repress target gene expression .
19179380	0	Ets-2	14,19	Bcl-xL	48,54	Ets-2	Bcl-xL	2114	598	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|dobj|expression expression|compound|END_ENTITY	Activation of Ets-2 by oxidative stress induces Bcl-xL expression and accounts for glial survival in amyotrophic lateral_sclerosis .
22740135	0	Ets-2	0,5	C1qTNF-related_protein_5	51,75	Ets-2	C1qTNF-related protein 5	23872(Tax:10090)	235312(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	Ets-2 is involved in transcriptional regulation of C1qTNF-related_protein_5 in muscle cells .
21437904	0	Ets-2	146,151	Smad2	118,123	Ets-2	Smad2	23872(Tax:10090)	17126(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transforming growth factor-b1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2 .
26185364	0	Ets-Like_Transcription_Factor_1	20,51	ICAM-1	70,76	Ets-Like Transcription Factor 1	ICAM-1	1999	3383	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|compound|END_ENTITY	Epithelium-Specific Ets-Like_Transcription_Factor_1 , ESE-1 , Regulates ICAM-1 Expression in Cultured Lung Epithelial Cell Lines .
15563472	0	Ets1	31,35	ERK1/2	51,57	Ets1	ERK1/2	2113	5595;5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells .
15699632	0	Ets1	0,4	ERK1/2	36,42	Ets1	ERK1/2	2113	5595;5594	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells .
12475968	0	Ets1	82,86	GM-CSF	22,28	Ets1	GM-CSF	2113	1437	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1 .
16840440	0	Ets1	61,65	HGF	0,3	Ets1	HGF	2113	3082	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB .
15699632	0	Ets1	0,4	K-ras	53,58	Ets1	K-ras	2113	3845	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells .
24646888	0	Ets1	20,24	Runx1	39,44	Ets1	Runx1	2113	861	Gene	Gene	basis|nmod|START_ENTITY activation|nsubj|basis activation|nmod|END_ENTITY	Structural basis of Ets1 activation by Runx1 .
10212281	1	Ets1	77,81	Tax1	139,143	Ets1	Tax1	2113	6900	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Ets1 and Ets2 , but not Elf-1 , cooperate with GATA3 and HTLV-I Tax1 .
23874775	0	Ets1	21,25	estrogen_receptor_a	42,61	Ets1	estrogen receptor a	2113	2099	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Transcription factor Ets1 cooperates with estrogen_receptor_a to stimulate estradiol-dependent growth in breast_cancer_cells_and_tumors .
24897113	0	Ets1	21,25	thioredoxin-interacting_protein	50,81	Ets1	thioredoxin-interacting protein	23871(Tax:10090)	56338(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Transcription factor Ets1 regulates expression of thioredoxin-interacting_protein and inhibits insulin secretion in pancreatic b-cells .
11278399	0	Ets2	179,183	Bcl-XL	0,6	Ets2	Bcl-XL	2114	598	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|compound|END_ENTITY	Bcl-XL expression correlates with primary macrophage differentiation , activation of functional competence , and survival and results from synergistic transcriptional activation by Ets2 and PU .1 .
21763315	0	Ets2	23,27	RuvBl2	0,6	Ets2	RuvBl2	2114	10856	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon_cancer .
23789107	0	Ets2	93,97	Trio	12,16	Ets2	Trio	2114	7204	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2 .
16518544	0	Ets2	22,26	p300	86,90	Ets2	p300	2114	2033	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	Transcription factors Ets2 and Sp1 act synergistically with histone acetyltransferase p300 in activating human interleukin-12 p40 promoter .
25109552	0	Etv1	0,4	Fgf10	55,60	Etv1	Fgf10	14009(Tax:10090)	14165(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal .
24727028	0	Etv2	24,28	Fli1	0,4	Etv2	Fli1	14008(Tax:10090)	14247(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation .
26876757	0	Etv4	194,198	Brain-derived_neurotrophic_factor	0,33	Etv4	Brain-derived neurotrophic factor	2118	627	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor promotes vesicular_glutamate_transporter_3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5 .
23799104	0	Eukaryotic_translation_elongation_factor_1-alpha_1	0,50	p53	60,63	Eukaryotic translation elongation factor 1-alpha 1	p53	1915	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Eukaryotic_translation_elongation_factor_1-alpha_1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity .
21633900	0	Eukaryotic_translation_elongation_factor_1_delta	0,48	SIAH-1	91,97	Eukaryotic translation elongation factor 1 delta	SIAH-1	1936	6477	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Eukaryotic_translation_elongation_factor_1_delta inhibits the ubiquitin ligase activity of SIAH-1 .
7673150	0	Eukaryotic_translation_initiation_factor_4E	0,43	cyclin_D1	68,77	Eukaryotic translation initiation factor 4E	cyclin D1	13684(Tax:10090)	12443(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Eukaryotic_translation_initiation_factor_4E regulates expression of cyclin_D1 at transcriptional and post-transcriptional levels .
17684707	0	Eukaryotic_translation_initiation_factor_4E	0,43	eIF4E	45,50	Eukaryotic translation initiation factor 4E	eIF4E	13684(Tax:10090)	13684(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- expression in the brain tissue is induced by infusion of nerve_growth_factor into the mouse cisterna magnum : an in vivo study .
23974830	0	Eukaryotic_translation_initiation_factor_4E	0,43	eIF4E	45,50	Eukaryotic translation initiation factor 4E	eIF4E	1977	1977	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- expression is associated with breast_cancer_tumor phenotype and predicts survival after anthracycline chemotherapy treatment .
9883583	0	Eva	53,56	epithelial_v-like_antigen	26,51	Eva	epithelial v-like antigen	14012(Tax:10090)	14012(Tax:10090)	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Expression pattern of the epithelial_v-like_antigen -LRB- Eva -RRB- transcript suggests a possible role in placental morphogenesis .
15278943	0	Evc	37,40	Ellis-van_Creveld	18,35	Evc	Ellis-van Creveld	289712(Tax:10116)	289712(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the Ellis-van_Creveld -LRB- Evc -RRB- gene in the rat tibial growth plate .
18337762	0	Evi-1	89,94	AML1	107,111	Evi-1	AML1	14013(Tax:10090)	12394(Tax:10090)	Gene	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1 .
21362509	0	Evi-1	18,23	PKC	47,50	Evi-1	PKC	2122	5580	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Evi-1 as a novel effector of PKC in the apoptotic response to DNA damage .
10511310	0	Evi-1	91,96	cyclin-dependent_kinase_2	46,71	Evi-1	cyclin-dependent kinase 2	2122	1017	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Loss of cell cycle control by deregulation of cyclin-dependent_kinase_2 kinase activity in Evi-1 transformed fibroblasts .
21289308	0	Evi1	0,4	PTEN	15,19	Evi1	PTEN	2122	5728	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins .
16204320	0	Evi1	21,25	Sox4	0,4	Evi1	Sox4	14013(Tax:10090)	20677(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Sox4 cooperates with Evi1 in AKXD-23 myeloid_tumors via transactivation of proviral LTR .
15580294	0	Evi3	0,4	EBF	56,59	Evi3	EBF	225207(Tax:10090)	13591(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Evi3 , a zinc-finger protein related to EBFAZ , regulates EBF activity in B-cell_leukemia .
14630787	0	Evi3	75,79	Early_hematopoietic_zinc_finger_protein	0,39	Evi3	Early hematopoietic zinc finger protein	225207(Tax:10090)	25925	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Early_hematopoietic_zinc_finger_protein -LRB- EHZF -RRB- , the human homolog to mouse Evi3 , is highly expressed in primitive human hematopoietic cells .
7506139	0	Evx-1	30,35	FGF-4	0,5	Evx-1	FGF-4	14028(Tax:10090)	14175(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FGF-4 regulates expression of Evx-1 in the developing mouse limb .
1372434	0	Evx-1	70,75	cytotactin	18,28	Evx-1	cytotactin	14028(Tax:10090)	21923(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|promoter promoter|compound|END_ENTITY	Activation of the cytotactin promoter by the homeobox-containing gene Evx-1 .
26085855	0	Excision_Repair_Cross-Complementation_Group_1	64,109	ERCC-1	111,117	Excision Repair Cross-Complementation Group 1	ERCC-1	2067	2067	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Correlation Analysis and Prognostic Impact of -LRB- 18 -RRB- F-FDG PET and Excision_Repair_Cross-Complementation_Group_1 -LRB- ERCC-1 -RRB- Expression in Non-Small_Cell_Lung_Cancer .
21091775	0	Excision_repair_cross-complementation_group_1	0,45	ERCC1	47,52	Excision repair cross-complementation group 1	ERCC1	2067	2067	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Excision_repair_cross-complementation_group_1 -LRB- ERCC1 -RRB- expression in advanced urothelial_carcinoma patients receiving cisplatin-based chemotherapy .
23939618	0	Exo1	46,50	PCNA	0,4	Exo1	PCNA	9156	5111	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	PCNA promotes processive DNA end resection by Exo1 .
15705715	0	Exo70	103,108	BIG2	15,19	Exo70	BIG2	23265	10564	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of BIG2 , a brefeldin_A-inhibited guanine_nucleotide-exchange protein , with exocyst protein Exo70 .
21639856	0	Exo70	0,5	SNEV	56,60	Exo70	SNEV	23265	27339	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Exo70 , a subunit of the exocyst complex , interacts with SNEV -LRB- hPrp19/hPso4 -RRB- and is involved in pre-mRNA splicing .
25829497	0	Exostosin	45,54	EXTL2	22,27	Exostosin	EXTL2	2131	2135	Gene	Gene	Family|compound|START_ENTITY Member|nmod|Family END_ENTITY|appos|Member	Reduced Expression of EXTL2 , a Member of the Exostosin -LRB- EXT -RRB- Family of Glycosyltransferases , in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains .
21991335	0	Exportin_4	0,10	Sox9	26,30	Exportin 4	Sox9	64328	6662	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Exportin_4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9 .
24832574	0	Extracellular_Matrix_Metalloproteinase_Inducer	10,56	EMMPRIN	58,65	Extracellular Matrix Metalloproteinase Inducer	EMMPRIN	682	682	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Increased Extracellular_Matrix_Metalloproteinase_Inducer -LRB- EMMPRIN -RRB- Expression in the Conjunctival Epithelium Exposed to Antiglaucoma Treatments .
22235371	0	Extracellular_Signal-Regulated_Kinase	0,37	ERK	39,42	Extracellular Signal-Regulated Kinase	ERK	5594	5594	Gene	Gene	Activation|compound|START_ENTITY Activation|appos|END_ENTITY	Extracellular_Signal-Regulated_Kinase -LRB- ERK -RRB- Activation and Mitogen-Activated_Protein_Kinase_Phosphatase_1 Induction by Pulsatile Gonadotropin-Releasing_Hormone in Pituitary Gonadotrophs .
26296887	0	Extracellular_Signal-regulated_Kinase	57,94	ERK	96,99	Extracellular Signal-regulated Kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|appos|END_ENTITY	Lipin1 Regulates Skeletal Muscle Differentiation through Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- Activation and Cyclin D Complex-regulated Cell Cycle Withdrawal .
17965264	0	Extracellular_matrix_metalloproteinase_inducer	0,46	CD147	47,52	Extracellular matrix metalloproteinase inducer	CD147	682	682	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Extracellular_matrix_metalloproteinase_inducer / CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction : implications in tissue remodeling .
24374756	0	Extracellular_matrix_metalloproteinase_inducer	0,46	EMMPRIN	48,55	Extracellular matrix metalloproteinase inducer	EMMPRIN	682	682	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- expression correlates positively with active angiogenesis and negatively with basic_fibroblast_growth_factor expression in epithelial_ovarian_cancer .
12603844	0	Extracellular_matrix_protein_1	0,30	ECM1	37,41	Extracellular matrix protein 1	ECM1	1893	1893	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Extracellular_matrix_protein_1 gene -LRB- ECM1 -RRB- mutations in lipoid_proteinosis and genotype-phenotype correlation .
16512877	0	Extracellular_matrix_protein_1	0,30	matrix_metalloproteinase_9	56,82	Extracellular matrix protein 1	matrix metalloproteinase 9	1893	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Extracellular_matrix_protein_1 inhibits the activity of matrix_metalloproteinase_9 through high-affinity protein/protein interactions .
11776327	0	Extracellular_signal-regulated_kinase	0,37	ERK	39,42	Extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation is required for GP_Ibalpha-dependent endothelial cell migration .
17764731	0	Extracellular_signal-regulated_kinase	0,37	ERK	39,42	Extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- inhibition does not prevent the development or expression of tolerance to and dependence on morphine in the mouse .
24047601	0	Extracellular_signal-regulated_kinase	0,37	ERK	39,42	Extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity during sleep consolidates cortical plasticity in vivo .
24682903	0	Extracellular_signal-regulated_kinase	0,37	ERK	39,42	Extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- expression and activation in mobile tongue_squamous_cell_carcinoma : associations with clinicopathological parameters and patients survival .
24708812	0	Extracellular_signal-regulated_kinase	0,37	ERK	39,42	Extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation is required for itch sensation in the spinal cord .
26115165	0	Extracellular_signal-regulated_kinase	0,37	ERK	39,42	Extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation is required for porcine_epidemic_diarrhea_virus replication .
19789340	0	Extracellular_signal-regulated_kinase	0,37	MCT-1	85,90	Extracellular signal-regulated kinase	MCT-1	5594	6566	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Extracellular_signal-regulated_kinase positively regulates the oncogenic activity of MCT-1 in diffuse large B-cell_lymphoma .
24043311	0	Extracellular_signal-regulated_kinase	0,37	RhoA	48,52	Extracellular signal-regulated kinase	RhoA	5594	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Extracellular_signal-regulated_kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine_exchange_factor_H1 activity .
27080258	0	Extracellular_signal-regulated_kinase	0,37	Y-Box_binding_protein_1	73,96	Extracellular signal-regulated kinase	Y-Box binding protein 1	5594	4904	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent phosphorylation of Y-Box_binding_protein_1 -LRB- YB-1 -RRB- enhances gene expression in granulosa cells in response to follicle stimulating hormone -LRB- FSH -RRB- .
10984495	0	Extracellular_signal-regulated_kinase	0,37	endothelin-1	88,100	Extracellular signal-regulated kinase	endothelin-1	24338(Tax:10116)	24323(Tax:10116)	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|agonists agonists|appos|hypertrophy hypertrophy|amod|END_ENTITY	Extracellular_signal-regulated_kinase plays an essential role in hypertrophic agonists , endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy .
24089523	0	Extracellular_signal-regulated_kinase	0,37	histone_deacetylase_6	59,80	Extracellular signal-regulated kinase	histone deacetylase 6	26413(Tax:10090)	15185(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- phosphorylates histone_deacetylase_6 -LRB- HDAC6 -RRB- at serine 1035 to stimulate cell migration .
10587355	0	Extracellular_signal-regulated_kinase	0,37	pre-T_cell_receptor	62,81	Extracellular signal-regulated kinase	pre-T cell receptor	5594	6962	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation by the pre-T_cell_receptor in developing thymocytes in vivo .
9765917	0	Extracellular_signal-regulated_kinase_1	0,39	Fc_gamma_RI	59,70	Extracellular signal-regulated kinase 1	Fc gamma RI	5595	2209	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Extracellular_signal-regulated_kinase_1 or 2 activation by Fc_gamma_RI aggregation in U937 cells .
19555684	0	Extracellular_signal-regulated_kinase_2	0,39	ERK-2	41,46	Extracellular signal-regulated kinase 2	ERK-2	5594	5594	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Extracellular_signal-regulated_kinase_2 -LRB- ERK-2 -RRB- mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein , RASSF2 .
23674093	0	Extracellular_signal-regulated_kinase_2	0,39	granulocyte_colony-stimulating_factor	67,104	Extracellular signal-regulated kinase 2	granulocyte colony-stimulating factor	5594	1440	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Extracellular_signal-regulated_kinase_2 mediates the expression of granulocyte_colony-stimulating_factor in invasive cancer cells .
9374727	0	Extracellular_superoxide_dismutase	0,34	inducible_nitric_oxide_synthase	55,86	Extracellular superoxide dismutase	inducible nitric oxide synthase	25352(Tax:10116)	24599(Tax:10116)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Extracellular_superoxide_dismutase is upregulated with inducible_nitric_oxide_synthase after NF-kappa B activation .
21334435	0	Extracellular_superoxide_dismutase	0,34	syndecan-1	59,69	Extracellular superoxide dismutase	syndecan-1	20657(Tax:10090)	20969(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Extracellular_superoxide_dismutase protects cardiovascular syndecan-1 from oxidative shedding .
25458011	0	Eya1	0,4	Six2	20,24	Eya1	Six2	2138	10736	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	Eya1 Interacts with Six2 and Myc to Regulate Expansion of the Nephron Progenitor Pool during Nephrogenesis .
25687760	0	Ezh1	33,37	Tollip	109,115	Ezh1	Tollip	14055(Tax:10090)	54473(Tax:10090)	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|dobj|Production Production|nmod|END_ENTITY	Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip .
21659531	0	Ezh2	82,86	Cyclin-dependent_kinase_1	0,25	Ezh2	Cyclin-dependent kinase 1	2146	983	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- - mediated phosphorylation of enhancer_of_zeste_2 -LRB- Ezh2 -RRB- regulates its stability .
20478051	0	Ezh2	34,38	HIF-1beta	107,116	Ezh2	HIF-1beta	2146	405	Gene	Gene	modulated|nsubjpass|START_ENTITY modulated|nmod|END_ENTITY	MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen_receptor and HIF-1alpha / HIF-1beta .
25790853	0	Ezh2	33,37	Igf1	14,18	Ezh2	Igf1	14056(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung .
18285464	0	Ezh2	0,4	PHF1	14,18	Ezh2	PHF1	2146	5252	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Ezh2 requires PHF1 to efficiently catalyze H3_lysine 27 trimethylation in vivo .
23135913	0	Ezh2	117,121	PTEN	17,21	Ezh2	PTEN	2146	5728	Gene	Gene	methyltransferase|amod|START_ENTITY activation|nmod|methyltransferase elicit|nmod|activation acts|xcomp|elicit acts|nmod|suppressor suppressor|compound|END_ENTITY	MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase .
23764001	0	Ezh2	79,83	Sox4	0,4	Ezh2	Sox4	2146	6659	Gene	Gene	expression|amod|START_ENTITY transition|nmod|expression regulator|nmod|transition regulator|nsubj|END_ENTITY	Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming .
24760151	0	Ezh2	0,4	T-bet	67,72	Ezh2	T-bet	14056(Tax:10090)	57765(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic_anemia in mice .
20814569	0	Ezh2	49,53	TNF	0,3	Ezh2	TNF	2146	7124	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression : implications in duchenne_muscular_dystrophy .
25266721	0	Ezh2	16,20	c-Rel	0,5	Ezh2	c-Rel	2146	5966	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells .
26149384	0	Ezrin	0,5	DDX3	37,41	Ezrin	DDX3	7430	1654	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Ezrin binds to DEAD-box RNA helicase DDX3 and regulates its function and protein level .
26936397	0	Ezrin	0,5	EGFR	15,19	Ezrin	EGFR	7430	1956	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non-Small_Cell_Lung_Cancer Cells .
12560083	0	Ezrin	0,5	Lck	25,28	Ezrin	Lck	7430	3932	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Ezrin is a substrate for Lck in T cells .
18840437	0	Ezrin	23,28	MicroRNA-183	0,12	Ezrin	MicroRNA-183	7430	406959	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-183 regulates Ezrin expression in lung_cancer cells .
21281239	0	Ezrin	46,51	P-glycoprotein	16,30	Ezrin	P-glycoprotein	7430	5243	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells .
18078820	0	Ezrin	0,5	PRL-3	70,75	Ezrin	PRL-3	7430	11156	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3 .
21281239	0	Ezrin	46,51	WAVE1	0,5	Ezrin	WAVE1	7430	8936	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells .
16352594	0	Ezrin	0,5	alpha1b-adrenergic_receptor	34,61	Ezrin	alpha1b-adrenergic receptor	7430	147	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ezrin directly interacts with the alpha1b-adrenergic_receptor and plays a role in receptor recycling .
18852256	0	Ezrin	0,5	cortactin	21,30	Ezrin	cortactin	7430	2017	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ezrin interacts with cortactin to form podosomal rosettes in pancreatic_cancer cells .
11468295	0	Ezrin	0,5	focal_adhesion_kinase	21,42	Ezrin	focal adhesion kinase	100153898(Tax:9823)	100170770(Tax:9823)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ezrin interacts with focal_adhesion_kinase and induces its activation independently of cell-matrix adhesion .
25337200	0	Ezrin	57,62	miR-183	0,7	Ezrin	miR-183	7430	406959	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-183 inhibits invasion of gastric_cancer by targeting Ezrin .
8227193	0	Ezrin	0,5	moesin	93,99	Ezrin	moesin	7430	4478	Gene	Gene	concentrated|nsubj|START_ENTITY concentrated|advcl|found found|nsubjpass|END_ENTITY	Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells .
25399891	0	Ezrin	9,14	tumor_necrosis_factor-a	89,112	Ezrin	tumor necrosis factor-a	54319(Tax:10116)	24835(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	-LSB- Role of Ezrin in the injury of rat pulmonary microvascular endothelial cells induced by tumor_necrosis_factor-a and the impact of Rac_1 -RSB- .
25492869	0	Ezrin-Radixin-Moesin-Binding_Phosphoprotein_50	19,65	EBP50	67,72	Ezrin-Radixin-Moesin-Binding Phosphoprotein 50	EBP50	9368	9368	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of Ezrin-Radixin-Moesin-Binding_Phosphoprotein_50 -LRB- EBP50 -RRB- by Akt Promotes Stability and Mitogenic Function of S-phase_Kinase_Associated_Protein-2 -LRB- Skp2 -RRB- .
25728696	0	F-Actin	54,61	Zyxin	0,5	F-Actin	Zyxin	40444(Tax:7227)	317824(Tax:7227)	Gene	Gene	Antagonizes|nmod|START_ENTITY Antagonizes|nsubj|END_ENTITY	Zyxin Antagonizes the FERM Protein Expanded to Couple F-Actin and Yorkie-Dependent Organ Growth .
23955342	0	F-box_and_WD_repeat_domain-containing-7	0,39	Fbxw7	41,46	F-box and WD repeat domain-containing-7	Fbxw7	50754(Tax:10090)	50754(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	F-box_and_WD_repeat_domain-containing-7 -LRB- Fbxw7 -RRB- protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation .
24469452	0	F-box_only_protein_2	0,20	amyloid_precursor_protein	39,64	F-box only protein 2	amyloid precursor protein	230904(Tax:10090)	11820(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	F-box_only_protein_2 -LRB- Fbxo2 -RRB- regulates amyloid_precursor_protein levels and processing .
24936062	0	F-box_only_protein_31	0,21	p38_mitogen-activated_protein_kinase	52,88	F-box only protein 31	p38 mitogen-activated protein kinase	79791	1432	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	F-box_only_protein_31 -LRB- FBXO31 -RRB- negatively regulates p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated_protein_kinase_kinase_6 -LRB- MKK6 -RRB- .
16227578	0	F-spondin	0,9	ApoEr2	57,63	F-spondin	ApoEr2	10418	7804	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	F-spondin interaction with the apolipoprotein_E receptor ApoEr2 affects processing of amyloid precursor protein .
21569239	0	F-spondin	49,58	F-spondin	69,78	F-spondin	F-spondin	10418	10418	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The structure of the Ca + - binding , glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein .
21569239	0	F-spondin	69,78	F-spondin	49,58	F-spondin	F-spondin	10418	10418	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The structure of the Ca + - binding , glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein .
25299387	0	F-spondin	0,9	LRP8	61,65	F-spondin	LRP8	233744(Tax:10090)	16975(Tax:10090)	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	F-spondin Inhibits Differentiation of Clastic Precursors via LRP8 .
26609477	0	F-spondin_1	102,113	microRNA-506	0,12	F-spondin 1	microRNA-506	10418	574511	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	microRNA-506 regulates proliferation , migration and invasion in hepatocellular_carcinoma by targeting F-spondin_1 -LRB- SPON1 -RRB- .
25627689	0	F0F1-ATPase	36,47	F0F1-ATPase	57,68	F0F1-ATPase	F0F1-ATPase	514	514	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Protein Kinase C-a Interaction with F0F1-ATPase Promotes F0F1-ATPase Activity and Reduces Energy Deficits in Injured Renal Cells .
25627689	0	F0F1-ATPase	57,68	F0F1-ATPase	36,47	F0F1-ATPase	F0F1-ATPase	514	514	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Protein Kinase C-a Interaction with F0F1-ATPase Promotes F0F1-ATPase Activity and Reduces Energy Deficits in Injured Renal Cells .
24066149	0	F11	18,21	Cyp4v3	30,36	F11	Cyp4v3	109821(Tax:10090)	102294(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Regulation of the F11 , Klkb1 , Cyp4v3 gene cluster in livers of metabolically challenged mice .
24066149	0	F11	18,21	Klkb1	23,28	F11	Klkb1	109821(Tax:10090)	16621(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Regulation of the F11 , Klkb1 , Cyp4v3 gene cluster in livers of metabolically challenged mice .
8922386	0	F11	97,100	NrCAM	82,87	F11	NrCAM	2160	4897	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites .
16254338	0	F1L	19,22	Bak	71,74	F1L	Bak	3707497(Tax:10245)	578	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The vaccinia_virus F1L protein interacts with the proapoptotic protein Bak and inhibits Bak activation .
19955184	0	F1L	15,18	Bak	34,37	F1L	Bak	3707497(Tax:10245)	578	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Vaccinia_virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1 .
26446588	0	F2R	18,21	PAR1	32,36	F2R	PAR1	2149	2149	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Evaluation of the F2R IVS-14A / T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention .
22403256	0	F4/80	112,117	CD11b	106,111	F4/80	CD11b	13733(Tax:10090)	16409(Tax:10090)	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1 + CD11b + F4/80 + regulatory macrophages in mice .
22403256	0	F4/80	112,117	CX3CR1	99,105	F4/80	CX3CR1	13733(Tax:10090)	13051(Tax:10090)	Gene	Gene	macrophages|compound|START_ENTITY macrophages|compound|END_ENTITY	Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1 + CD11b + F4/80 + regulatory macrophages in mice .
19423085	0	F4/80	34,39	PPAR_gamma	0,10	F4/80	PPAR gamma	13733(Tax:10090)	19016(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	PPAR_gamma is highly expressed in F4/80 -LRB- hi -RRB- adipose tissue macrophages and dampens adipose-tissue inflammation .
11748850	0	F8C	67,70	factor_VIII	54,65	F8C	factor VIII	2157	2157	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Seven novel and four recurrent point mutations in the factor_VIII -LRB- F8C -RRB- gene .
11754115	0	F8C	67,70	factor_VIII	54,65	F8C	factor VIII	2157	2157	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Seven novel and four recurrent point mutations in the factor_VIII -LRB- F8C -RRB- gene .
9760209	0	F8C	68,71	factor_VIII	55,66	F8C	factor VIII	2157	2157	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation of site-specific methylation patterns in the factor_VIII -LRB- F8C -RRB- gene in human sperm DNA .
1875328	0	FA-1	19,23	ZP3	35,38	FA-1	ZP3	2175	7784	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human spermatozoal FA-1 binds with ZP3 of porcine zona pellucida .
16894551	0	FA-1	33,37	fertilization_antigen	10,31	FA-1	fertilization antigen	20826(Tax:10090)	20826(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of fertilization_antigen -LRB- FA-1 -RRB- DNA vaccine on fertility of female mice .
9721219	0	FAA	58,61	Fanconi_anemia_group_A	34,56	FAA	Fanconi anemia group A	2184	2184	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fine exon-intron structure of the Fanconi_anemia_group_A -LRB- FAA -RRB- gene and characterization of two genomic deletions .
25754762	0	FAAH	39,43	Fatty_Acid_Amide_Hydrolase	11,37	FAAH	Fatty Acid Amide Hydrolase	2166	2166	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Effects of Fatty_Acid_Amide_Hydrolase -LRB- FAAH -RRB- Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse .
17553686	0	FAAH	53,57	fatty_acid_amide_hydrolase	25,51	FAAH	fatty acid amide hydrolase	2166	2166	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Severe deficiency of the fatty_acid_amide_hydrolase -LRB- FAAH -RRB- activity segregates with the Huntington 's _ disease mutation in peripheral lymphocytes .
19554599	0	FAAH	91,95	fatty_acid_amide_hydrolase	63,89	FAAH	fatty acid amide hydrolase	2166	2166	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure-property relationships of a class of carbamate-based fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors : chemical and biological stability .
20570023	0	FAAH	95,99	fatty_acid_amide_hydrolase	67,93	FAAH	fatty acid amide hydrolase	2166	2166	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Chemistry around imidazopyrazine and ibuprofen : discovery of novel fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors .
21820769	0	FAAH	61,65	fatty_acid_amide_hydrolase	33,59	FAAH	fatty acid amide hydrolase	29347(Tax:10116)	29347(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Biphenyl-3-yl_alkylcarbamates as fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors : steric effects of N-alkyl chain on rat plasma and liver stability .
23218778	0	FAAH	111,115	fatty_acid_amide_hydrolase	83,109	FAAH	fatty acid amide hydrolase	14073(Tax:10090)	14073(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis , SAR study , and biological evaluation of a series of piperazine ureas as fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors .
24275607	0	FAAH	42,46	fatty_acid_amide_hydrolase	14,40	FAAH	fatty acid amide hydrolase	2166	2166	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- as a novel therapeutic strategy in the treatment of pain and inflammatory_diseases in the gastrointestinal tract .
25338703	0	FAAH	90,94	fatty_acid_amide_hydrolase	62,88	FAAH	fatty acid amide hydrolase	29347(Tax:10116)	29347(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	O - -LRB- triazolyl -RRB- methyl_carbamates as a novel and potent class of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors .
26558620	0	FAAH	39,43	fatty_acid_amide_hydrolase	11,37	FAAH	fatty acid amide hydrolase	29347(Tax:10116)	29347(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors on working memory in rats .
15611632	1	FAAP95	85,91	BRCA2	101,106	FAAP95	BRCA2	2187	675	Gene	Gene	replaces|nsubj|START_ENTITY replaces|dobj|END_ENTITY	FAAP95 replaces BRCA2 as the true FANCB protein .
19554614	0	FABP	73,77	fatty-acid_binding_protein	45,71	FABP	fatty-acid binding protein	2806	2806	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Association analyses between brain-expressed fatty-acid_binding_protein -LRB- FABP -RRB- genes and schizophrenia and bipolar_disorder .
22640736	0	FABP1	19,24	PDX1	0,4	FABP1	PDX1	2168	3651	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells .
23468166	0	FABP2	85,90	angiotensin-converting_enzyme	15,44	FABP2	angiotensin-converting enzyme	2169	1636	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Association of angiotensin-converting_enzyme -LRB- ACE -RRB- and fatty_acid binding protein 2 -LRB- FABP2 -RRB- genes polymorphism with type 2 diabetes_mellitus in Northern India .
24129192	0	FABP3	0,5	UCP1	139,143	FABP3	UCP1	14077(Tax:10090)	22227(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	FABP3 and brown adipocyte-characteristic mitochondrial fatty_acid oxidation enzymes are induced in beige cells in a different pathway from UCP1 .
26606905	0	FABP4	66,71	DNMT1	103,108	FABP4	DNMT1	11770(Tax:10090)	13433(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE -LRB- - / - -RRB- mice .
19911253	0	FABP4	96,101	PTEN	47,51	FABP4	PTEN	2167	5728	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Identification of novel PTEN-binding partners : PTEN interaction with fatty_acid binding protein FABP4 .
24244493	0	FABP4/5	55,62	fatty_acid_binding_protein_4_and_5	19,53	FABP4/5	fatty acid binding protein 4 and 5	11770;16592	11770(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A critical role of fatty_acid_binding_protein_4_and_5 -LRB- FABP4/5 -RRB- in the systemic response to fasting .
22583899	0	FABP7	18,23	PAX6	32,36	FABP7	PAX6	2173	5080	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the FABP7 gene by PAX6 in malignant_glioma cells .
9378851	0	FAC1	45,49	fetal_ALZ-50_reactive_clone_1	14,43	FAC1	fetal ALZ-50 reactive clone 1	2186	2186	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of fetal_ALZ-50_reactive_clone_1 -LRB- FAC1 -RRB- in dentate gyrus_following_entorhinal_cortex_lesion .
24169522	0	FACE1	14,19	ZMPSTE24	4,12	FACE1	ZMPSTE24	10269	10269	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	New ZMPSTE24 -LRB- FACE1 -RRB- mutations in patients affected with restrictive_dermopathy or related progeroid syndromes and mutation update .
20700539	0	FAD	0,3	amyloid_precursor_protein	17,42	FAD	amyloid precursor protein	5663	351	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	FAD mutations in amyloid_precursor_protein do not directly perturb intracellular calcium homeostasis .
18029353	0	FAD24	0,5	HBO1	53,57	FAD24	HBO1	64318	11143	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication .
23828893	0	FADD	56,60	Fas-associated_death_domain-containing_protein	8,54	FADD	Fas-associated death domain-containing protein	14082(Tax:10090)	14082(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Fas-associated_death_domain-containing_protein -LRB- FADD -RRB- phosphorylation in regulating glucose homeostasis : from proteomic discovery to physiological validation .
24058479	0	FADD	62,66	Fas-associated_death_domain-containing_protein	14,60	FADD	Fas-associated death domain-containing protein	14082(Tax:10090)	14082(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Fas-associated_death_domain-containing_protein -LRB- FADD -RRB- protects against myocardial_ischemia / reperfusion injury in a heart_failure mouse model .
9582077	0	FADD	37,41	Mort1	43,48	FADD	Mort1	8772	8772	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	NMR structure and mutagenesis of the FADD -LRB- Mort1 -RRB- death-effector domain .
15289496	0	FADD	47,51	NFkappaB	0,8	FADD	NFkappaB	8772	4790	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|activation activation|amod|END_ENTITY	NFkappaB activation by Fas is mediated through FADD , caspase-8 , and RIP and is inhibited by FLIP .
9488730	0	FADD	56,60	acid_sphingomyelinase	82,103	FADD	acid sphingomyelinase	8772	6609	Gene	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid_sphingomyelinase .
11859411	0	FADD	62,66	caspase-8	84,93	FADD	caspase-8	8772	841	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Induction of apoptosis by chemotherapeutic drugs : the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian_carcinoma cells .
12196516	0	FADD	51,55	caspase-8	57,66	FADD	caspase-8	14082(Tax:10090)	12370(Tax:10090)	Gene	Gene	mitochondria|nmod|START_ENTITY END_ENTITY|nmod|mitochondria	TRAIL receptor and CD95 signal to mitochondria via FADD , caspase-8 / 10 , Bid , and Bax but differentially regulate events downstream from truncated Bid .
18840411	0	FADD	50,54	caspase-8	57,66	FADD	caspase-8	8772	841	Gene	Gene	DR5|dep|START_ENTITY DR5|dep|END_ENTITY	c-FLIP knockdown induces ligand-independent DR5 - , FADD - , caspase-8 - , and caspase-9-dependent apoptosis in breast_cancer cells .
21706480	0	FADD	107,111	miR-155	12,19	FADD	miR-155	8772	406947	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral_disc_degeneration by targeting FADD and caspase-3 .
16670158	0	FADS1	31,36	FADS2	37,42	FADS1	FADS2	3992	9415	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty_acid composition in phospholipids .
18936223	0	FADS1	24,29	FADS2	30,35	FADS1	FADS2	3992	9415	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Genetic variants of the FADS1 FADS2 gene cluster are associated with altered -LRB- n-6 -RRB- and -LRB- n-3 -RRB- essential fatty_acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation .
19809313	0	FADS1	24,29	FADS2	30,35	FADS1	FADS2	3992	9415	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty_acid metabolism .
20691134	0	FADS1	25,30	FADS2	31,36	FADS1	FADS2	3992	9415	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study .
20948998	0	FADS1	16,21	FADS2	22,27	FADS1	FADS2	3992	9415	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Variants of the FADS1 FADS2 gene cluster , blood levels of polyunsaturated_fatty_acids and eczema in children within the first 2 years of life .
22629455	0	FADS1	0,5	FADS2	6,11	FADS1	FADS2	3992	9415	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	FADS1 FADS2 gene cluster , PUFA intake and blood lipids in children : results from the GINIplus and LISAplus studies .
16670158	0	FADS2	37,42	FADS1	31,36	FADS2	FADS1	9415	3992	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty_acid composition in phospholipids .
18936223	0	FADS2	30,35	FADS1	24,29	FADS2	FADS1	9415	3992	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Genetic variants of the FADS1 FADS2 gene cluster are associated with altered -LRB- n-6 -RRB- and -LRB- n-3 -RRB- essential fatty_acids in plasma and erythrocyte phospholipids in women during pregnancy and in breast milk during lactation .
19809313	0	FADS2	30,35	FADS1	24,29	FADS2	FADS1	9415	3992	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty_acid metabolism .
20691134	0	FADS2	31,36	FADS1	25,30	FADS2	FADS1	9415	3992	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study .
20948998	0	FADS2	22,27	FADS1	16,21	FADS2	FADS1	9415	3992	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Variants of the FADS1 FADS2 gene cluster , blood levels of polyunsaturated_fatty_acids and eczema in children within the first 2 years of life .
22629455	0	FADS2	6,11	FADS1	0,5	FADS2	FADS1	9415	3992	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	FADS1 FADS2 gene cluster , PUFA intake and blood lipids in children : results from the GINIplus and LISAplus studies .
25575590	0	FAH_Domain-containing_Protein_1	18,49	Oxaloacetate_Decarboxylase	61,87	FAH Domain-containing Protein 1	Oxaloacetate Decarboxylase	81889	81889	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of FAH_Domain-containing_Protein_1 -LRB- FAHD1 -RRB- as Oxaloacetate_Decarboxylase .
11483211	0	FAIM	73,77	Fas_apoptosis_inhibitory_molecule	38,71	FAIM	Fas apoptosis inhibitory molecule	23873(Tax:10090)	23873(Tax:10090)	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	An alternatively spliced long form of Fas_apoptosis_inhibitory_molecule -LRB- FAIM -RRB- with tissue-specific expression in the brain .
26568247	0	FAIM3	32,37	PLAC8	38,43	FAIM3	PLAC8	9214	51316	Gene	Gene	Validation|nmod|START_ENTITY Validation|dep|Ratio Ratio|compound|END_ENTITY	Comprehensive Validation of the FAIM3 : PLAC8 Ratio in Time-matched Public Gene Expression Data .
26568248	0	FAIM3	39,44	PLAC8	45,50	FAIM3	PLAC8	9214	51316	Gene	Gene	Validation|nmod|START_ENTITY Reply|dep|Validation Reply|dep|Ratio Ratio|compound|END_ENTITY	Reply : Comprehensive Validation of the FAIM3 : PLAC8 Ratio in Time-matched Public Gene Expression Data .
26720791	0	FAIM3	0,5	PLAC8	6,11	FAIM3	PLAC8	9214	51316	Gene	Gene	START_ENTITY|dep|Ratio Ratio|compound|END_ENTITY	FAIM3 : PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired_Pneumonia : Comparing Apples to Oranges ?
26720792	0	FAIM3	7,12	PLAC8	13,18	FAIM3	PLAC8	9214	51316	Gene	Gene	START_ENTITY|dep|Ratio Ratio|compound|END_ENTITY	Reply : FAIM3 : PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired_Pneumonia : Comparing Apples to Oranges ?
18662671	0	FAK	25,28	ARHGAP21	0,8	FAK	ARHGAP21	25614(Tax:10116)	307178(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload .
18414015	0	FAK	59,62	C-FLIP	0,6	FAK	C-FLIP	5747	8837	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	C-FLIP promotes the motility of cancer cells by activating FAK and ERK , and increasing MMP-9 expression .
16406804	0	FAK	115,118	CXCR1	38,43	FAK	CXCR1	14083(Tax:10090)	227288(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY converge|nmod|pathways mechanisms|acl|converge phosphorylation|dep|mechanisms phosphorylation|nmod|END_ENTITY	CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2 : cytoskeleton - and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner .
16406804	0	FAK	14,17	CXCR1	38,43	FAK	CXCR1	14083(Tax:10090)	227288(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	CXCL8-induced FAK phosphorylation via CXCR1 and CXCR2 : cytoskeleton - and integrin-related mechanisms converge with FAK regulatory pathways in a receptor-specific manner .
18444244	0	FAK	97,100	Carbonic_anhydrase_III	0,22	FAK	Carbonic anhydrase III	5747	761	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Carbonic_anhydrase_III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway .
21412826	0	FAK	36,39	Cbfa1	48,53	FAK	Cbfa1	14083(Tax:10090)	12393(Tax:10090)	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Integrin-associated tyrosine kinase FAK affects Cbfa1 expression .
23168795	0	FAK	0,3	Cdk2	14,18	FAK	Cdk2	5747	1017	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	FAK regulates Cdk2 in EGF-stimulated primary cultures of hepatocytes .
14712065	0	FAK	24,27	Cdk5	0,4	FAK	Cdk5	5747	1020	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration .
20811717	0	FAK	116,119	ERK	78,81	FAK	ERK	5747	5594	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	P21-activated protein kinase 1 induces colorectal_cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910 .
18247360	0	FAK	22,25	Elk-1	0,5	FAK	Elk-1	5747	2002	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Elk-1 associates with FAK , regulates the expression of FAK and MAP kinases as well as apoptosis in HK-2 cells .
21637765	0	FAK	89,92	Epithelial_membrane_protein-2	0,29	FAK	Epithelial membrane protein-2	5747	2013	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Epithelial_membrane_protein-2 promotes endometrial_tumor formation through activation of FAK and Src .
11315093	0	FAK	23,26	Focal_adhesion_kinase	0,21	FAK	Focal adhesion kinase	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Focal_adhesion_kinase -LRB- FAK -RRB- phosphorylation is not required for genistein-induced FAK-beta-1-integrin complex formation .
15161103	0	FAK	23,26	Focal_adhesion_kinase	0,21	FAK	Focal adhesion kinase	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Focal_adhesion_kinase -LRB- FAK -RRB- expression and phosphorylation in sea urchin embryos .
11468287	0	FAK	38,41	Fyn	13,16	FAK	Fyn	14083(Tax:10090)	14360(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Dual role of Fyn in the regulation of FAK +6,7 by cannabinoids in hippocampus .
26914403	0	FAK	46,49	GPER	40,44	FAK	GPER	5747	2852	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
25218495	0	FAK	58,61	GRP78	0,5	FAK	GRP78	5747	3309	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	GRP78 promotes the invasion of pancreatic_cancer cells by FAK and JNK .
10521801	0	FAK	12,15	HGF	0,3	FAK	HGF	14083(Tax:10090)	15234(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast_carcinoma cells .
17550607	0	FAK	130,133	Hic-5	27,32	FAK	Hic-5	25614(Tax:10116)	84574(Tax:10116)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK .
15778501	0	FAK	125,128	JNK	115,118	FAK	JNK	5747	5599	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix : JNK links FAK and p53 .
19661918	0	FAK	99,102	MBD2	120,124	FAK	MBD2	14083(Tax:10090)	17191(Tax:10090)	Gene	Gene	differentiation|nmod|START_ENTITY remodelling|nmod|differentiation Regulation|nmod|remodelling interaction|nsubj|Regulation interaction|nmod|END_ENTITY	Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2 .
19949307	0	FAK	0,3	MBD2	21,25	FAK	MBD2	5747	8932	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	FAK interaction with MBD2 : A link from cell adhesion to nuclear chromatin remodeling ?
23175848	0	FAK	23,26	Neurofibromin	0,13	FAK	Neurofibromin	37233(Tax:7227)	43149(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|compound|END_ENTITY	Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila_neuromuscular_junctions .
19595712	0	FAK	76,79	PIN1	92,96	FAK	PIN1	14083(Tax:10090)	23988(Tax:10090)	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST .
12741393	0	FAK	0,3	Prx1	26,30	FAK	Prx1	14083(Tax:10090)	18933(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration .
18391070	0	FAK	86,89	Pyk2	22,26	FAK	Pyk2	14083(Tax:10090)	19229(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK .
25118939	0	FAK	0,3	Src	17,20	FAK	Src	14083(Tax:10090)	20779(Tax:10090)	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	FAK competes for Src to promote migration against invasion in melanoma cells .
26914403	0	FAK	46,49	Src	51,54	FAK	Src	5747	6714	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
26466961	0	FAK	134,137	TLR4	87,91	FAK	TLR4	14083(Tax:10090)	21898(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88 .
23272972	0	FAK	51,54	cMET	30,34	FAK	cMET	5747	4233	Gene	Gene	Inhibiting|nmod|START_ENTITY Inhibiting|dobj|interaction interaction|nmod|END_ENTITY	Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic_cancer cells in vitro and in vivo .
11606050	0	FAK	55,58	focal_adhesion_kinase	32,53	FAK	focal adhesion kinase	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Uniaxial cyclic stretch induces focal_adhesion_kinase -LRB- FAK -RRB- tyrosine phosphorylation followed by mitogen-activated protein kinase -LRB- MAPK -RRB- activation .
12215217	0	FAK	47,50	focal_adhesion_kinase	24,45	FAK	focal adhesion kinase	5747	5747	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Antiapoptotic action of focal_adhesion_kinase -LRB- FAK -RRB- against ionizing radiation .
15174091	0	FAK	43,46	focal_adhesion_kinase	20,41	FAK	focal adhesion kinase	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	PDGF and FGF induce focal_adhesion_kinase -LRB- FAK -RRB- phosphorylation at Ser-910 : dissociation from Tyr-397 phosphorylation and requirement for ERK activation .
15564794	0	FAK	39,42	focal_adhesion_kinase	16,37	FAK	focal adhesion kinase	5747	5747	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of focal_adhesion_kinase -LRB- FAK -RRB- expression in ductal_carcinoma_in_situ -LRB- DCIS -RRB- is an early event in breast tumorigenesis .
16179862	0	FAK	58,61	focal_adhesion_kinase	10,31	FAK	focal adhesion kinase	5747	5747	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	Effect of focal_adhesion_kinase -LRB- FAK -RRB- downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines .
23275034	0	FAK	37,40	focal_adhesion_kinase	14,35	FAK	focal adhesion kinase	5747	5747	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Inhibition of focal_adhesion_kinase -LRB- FAK -RRB- activity prevents anchorage-independent ovarian_carcinoma cell growth and tumor progression .
7525620	0	FAK	46,49	focal_adhesion_kinase	23,44	FAK	focal adhesion kinase	399286(Tax:8355)	399286(Tax:8355)	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of pp125 focal_adhesion_kinase -LRB- FAK -RRB- at the myotendinous junction .
17879163	0	FAK	147,150	integrin_alpha_v	100,116	FAK	integrin alpha v	5747	3685	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	An altered fibronectin matrix induces anoikis of human squamous_cell_carcinoma cells by suppressing integrin_alpha_v levels and phosphorylation of FAK and ERK .
17113264	0	FAK	28,31	transforming_growth_factor-beta1	43,75	FAK	transforming growth factor-beta1	5747	7040	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Combinatorial activation of FAK and AKT by transforming_growth_factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts .
16998626	0	FAK-related_non-kinase	14,36	FRNK	38,42	FAK-related non-kinase	FRNK	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of FAK-related_non-kinase -LRB- FRNK -RRB- coincides with morphological change in the early stage of cell adhesion .
26721396	0	FAM129B	20,27	EGFR	0,4	FAM129B	EGFR	64855	1956	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	EGFR phosphorylates FAM129B to promote Ras activation .
24973512	0	FAM134B	19,26	JK-1	13,17	FAM134B	JK-1	54463	54463	Gene	Gene	expressions|appos|START_ENTITY expressions|amod|END_ENTITY	The roles of JK-1 -LRB- FAM134B -RRB- expressions in colorectal_cancer .
23939472	0	FAM134C	12,19	NRF-1	56,61	FAM134C	NRF-1	162427	4899	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Novel genes FAM134C , C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons .
25109685	0	FAM19A4	0,7	formyl_peptide_receptor_1	38,63	FAM19A4	formyl peptide receptor 1	151647	2357	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	FAM19A4 is a novel cytokine ligand of formyl_peptide_receptor_1 -LRB- FPR1 -RRB- and is able to promote the migration and phagocytosis of macrophages .
24202787	0	FAM36A	74,80	COX20	67,72	FAM36A	COX20	116228	116228	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Recessive dystonia-ataxia_syndrome in a Turkish family caused by a COX20 -LRB- FAM36A -RRB- mutation .
23562554	0	FAM3A	0,5	peroxisome_proliferator-activated_receptor_gamma	26,74	FAM3A	peroxisome proliferator-activated receptor gamma	60343	5468	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	FAM3A is a target gene of peroxisome_proliferator-activated_receptor_gamma .
21664946	0	FAM3B	43,48	pancreatic_derived_factor	16,41	FAM3B	pancreatic derived factor	52793(Tax:10090)	52793(Tax:10090)	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of pancreatic_derived_factor -LRB- FAM3B -RRB- expression in pancreatic b-cells by MCP-1 -LRB- CCL2 -RRB- .
22984288	0	FAM60A	51,57	family_with_sequence_similarity_60_member_A	6,49	FAM60A	family with sequence similarity 60 member A	58516	58516	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Human family_with_sequence_similarity_60_member_A -LRB- FAM60A -RRB- protein : a new subunit of the Sin3 deacetylase complex .
26758433	0	FAM83F	48,54	miR-143	0,7	FAM83F	miR-143	113828	406935	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-143 inhibits tumor progression by targeting FAM83F in esophageal_squamous_cell_carcinoma .
26503212	0	FAM98A	0,6	PRMT1	31,36	FAM98A	PRMT1	25940	3276	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	FAM98A is a novel substrate of PRMT1 required for tumor cell migration , invasion , and colony formation .
26825979	0	FAM98A	12,18	PRMT1	43,48	FAM98A	PRMT1	25940	3276	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Erratum to : FAM98A is a novel substrate of PRMT1 required for tumor cell migration , invasion and colony formation .
10522869	0	FAME	63,67	familial_adult_myoclonic_epilepsy	28,61	FAME	familial adult myoclonic epilepsy	50968	50968	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic localization of the familial_adult_myoclonic_epilepsy -LRB- FAME -RRB- gene to chromosome 8q24 .
15075251	0	FAN	49,52	Bid	67,70	FAN	Bid	353233(Tax:10116)	64625(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|dependent dependent|dep|END_ENTITY	TNF-alpha-mediated lysosomal permeabilization is FAN and caspase_8 / Bid dependent .
20534702	0	FAN	0,3	TNF-R1	92,98	FAN	TNF-R1	8439	7132	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	FAN -LRB- factor associated with neutral sphingomyelinase activation -RRB- , a moonlighting protein in TNF-R1 signaling .
12354784	0	FANCA	57,62	BRCA1	0,5	FANCA	BRCA1	2175	672	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRCA1 interacts directly with the Fanconi_anemia protein FANCA .
15611632	1	FANCB	119,124	BRCA2	101,106	FANCB	BRCA2	2187	675	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	FAAP95 replaces BRCA2 as the true FANCB protein .
11500375	0	FANCC	0,5	Hsp70	21,26	FANCC	Hsp70	2176	3308	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity .
12239151	0	FANCD2	60,66	BRCA1	73,78	FANCD2	BRCA1	2177	672	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	S-phase-specific interaction of the Fanconi_anemia protein , FANCD2 , with BRCA1 and RAD51 .
15115758	0	FANCD2	22,28	BRCA2	34,39	FANCD2	BRCA2	2177	675	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways .
15671039	0	FANCD2	41,47	BRCA2	76,81	FANCD2	BRCA2	2177	675	Gene	Gene	D2|appos|START_ENTITY functions|nsubj|D2 functions|nmod|recombination recombination|amod|END_ENTITY	Fanconi_anemia complementation group D2 -LRB- FANCD2 -RRB- functions independently of BRCA2 - and RAD51-associated homologous recombination in response to DNA damage .
24794430	0	FANCD2	0,6	CtIP	13,17	FANCD2	CtIP	2177	5932	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	FANCD2 binds CtIP and regulates DNA-end resection during DNA interstrand crosslink repair .
19633289	0	FANCD2	50,56	FANCM	27,32	FANCD2	FANCM	734196(Tax:8355)	100286772(Tax:8355)	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	The Fanconi_anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways .
25176410	0	FANCD2	0,6	caspase_3	23,32	FANCD2	caspase 3	2177	836	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	FANCD2 is a target for caspase_3 during DNA damage-induced apoptosis .
23538752	0	FANCD2	58,64	mTOR	0,4	FANCD2	mTOR	2177	21977(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	mTOR regulates DNA damage response through NF-kB-mediated FANCD2 pathway in hematopoietic cells .
23633493	0	FANCD2	14,20	mTOR	28,32	FANCD2	mTOR	2177	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks .
23852546	0	FANCD2	115,121	mTOR	0,4	FANCD2	mTOR	2177	21977(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY damage|nmod|expression T-cell_lymphoblastic_leukemia|nmod|damage sensitizes|dobj|T-cell_lymphoblastic_leukemia sensitizes|nsubj|inhibitor inhibitor|compound|END_ENTITY	mTOR kinase inhibitor sensitizes T-cell_lymphoblastic_leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression .
11756225	0	FANCG	4,9	CYP2E1	48,54	FANCG	CYP2E1	2189	1571	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	The FANCG Fanconi_anemia protein interacts with CYP2E1 : possible role in protection against oxidative DNA damage .
19150983	0	FANCJ	0,5	ATPase	21,27	FANCJ	ATPase	83990	1769	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	FANCJ uses its motor ATPase to destabilize protein-DNA complexes , unwind triplexes , and inhibit RAD51 strand exchange .
14712086	0	FANCL	0,5	BRCA1	15,20	FANCL	BRCA1	55120	672	Gene	Gene	replaces|nsubj|START_ENTITY replaces|dobj|END_ENTITY	FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination .
21229326	0	FANCL	21,26	UBE2W	0,5	FANCL	UBE2W	55120	55284	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi_anemia protein FANCD2 .
19633289	0	FANCM	27,32	FANCD2	50,56	FANCM	FANCD2	100286772(Tax:8355)	734196(Tax:8355)	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	The Fanconi_anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways .
26825464	0	FANCM	0,5	PCNA	21,25	FANCM	PCNA	57697	5111	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks .
27060496	0	FANK1	33,38	RYBP	13,17	FANK1	RYBP	92565	23429	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway .
25331442	0	FAP	59,62	Fibroblast_Activation_Protein_Alpha	22,57	FAP	Fibroblast Activation Protein Alpha	2191	2191	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Stromal Expression of Fibroblast_Activation_Protein_Alpha -LRB- FAP -RRB- Predicts Platinum Resistance and Shorter Recurrence in patients with Epithelial_Ovarian_Cancer .
2403740	0	FAP	65,68	feto-acinar_pancreatic_protein	33,63	FAP	feto-acinar pancreatic protein	1056	1056	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	An immunohistologic study of the feto-acinar_pancreatic_protein -LRB- FAP -RRB- in the normal pancreas , chronic pancreatitis , pancreatic_adenocarcinoma , and intraabdominal metastases of adenocarcinomas .
10544233	0	FAP-1	56,61	Fas-associated_phosphatase-1	26,54	FAP-1	Fas-associated phosphatase-1	5783	5783	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- with p75 -LRB- NTR -RRB- and their effect on NF-kappaB activation .
9665752	0	FAP-1	49,54	Fas-associated_phosphatase-1	19,47	FAP-1	Fas-associated phosphatase-1	5783	5783	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- in interleukin-2-activated T cells .
20620960	0	FAP-1	68,73	miR-200c	0,8	FAP-1	miR-200c	5783	406985	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1 .
10544233	0	FAP-1	56,61	p75	68,71	FAP-1	p75	5783	7133	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- with p75 -LRB- NTR -RRB- and their effect on NF-kappaB activation .
10998178	0	FAP1	0,4	NF-X1	48,53	FAP1	NF-X1	5783	4799	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	FAP1 , a homologue of human transcription factor NF-X1 , competes with rapamycin for binding to FKBP12 in yeast .
21525334	0	FAR-RED_INSENSITIVE219	0,22	CONSTITUTIVE_PHOTOMORPHOGENIC1	33,63	FAR-RED INSENSITIVE219	CONSTITUTIVE PHOTOMORPHOGENIC1	819244(Tax:3702)	817857(Tax:3702)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nummod|END_ENTITY	FAR-RED_INSENSITIVE219 modulates CONSTITUTIVE_PHOTOMORPHOGENIC1 activity via physical interaction to regulate hypocotyl elongation in Arabidopsis .
11889039	0	FAR1	114,118	phytochrome_A	31,44	FAR1	phytochrome A	827173(Tax:3702)	837483(Tax:3702)	Gene	Gene	interacting|nmod|START_ENTITY signaling|advcl|interacting END_ENTITY|acl|signaling	Arabidopsis FHY3 defines a key phytochrome_A signaling component directly interacting with its homologous partner FAR1 .
19217374	0	FARP1	0,5	Semaphorin6A	90,102	FARP1	Semaphorin6A	10160	57556	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling .
17825601	0	FAS	31,34	ErbB2	0,5	FAS	ErbB2	2194	2064	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	ErbB2 and fatty_acid synthase -LRB- FAS -RRB- expression in 102 squamous_cell_carcinomas of the tongue : correlation with clinical outcomes .
10103003	0	FAS	54,57	fatty_acid_synthase	33,52	FAS	fatty acid synthase	50671(Tax:10116)	50671(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	FIRE3 in the promoter of the rat fatty_acid_synthase -LRB- FAS -RRB- gene binds the ubiquitous transcription factors CBF_and_USF but does not mediate an insulin response in a rat hepatoma cell line .
12766036	0	FAS	56,59	fatty_acid_synthase	35,54	FAS	fatty acid synthase	2194	2194	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the lipogenic enzyme fatty_acid_synthase -LRB- FAS -RRB- in retinoblastoma and its correlation with tumor_aggressiveness .
15235125	0	FAS	35,38	fatty_acid_synthase	14,33	FAS	fatty acid synthase	2194	2194	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of fatty_acid_synthase -LRB- FAS -RRB- suppresses HER2/neu -LRB- erbB-2 -RRB- oncogene overexpression in cancer cells .
19223187	0	FAS	27,30	fatty_acid_synthase	6,25	FAS	fatty acid synthase	2194	2194	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Novel fatty_acid_synthase -LRB- FAS -RRB- inhibitors : design , synthesis , biological evaluation , and molecular docking studies .
8630954	0	FAS	35,38	fatty_acid_synthase	14,33	FAS	fatty acid synthase	2194	2194	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of fatty_acid_synthase -LRB- FAS -RRB- as a predictor of recurrence in stage I breast_carcinoma patients .
7925441	0	FAS1	118,122	Rap1p	41,46	FAS1	Rap1p	853653(Tax:4932)	855505(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Importance of general regulatory factors Rap1p , Abf1p and Reb1p for the activation of yeast fatty_acid synthase genes FAS1 and FAS2 .
15899806	0	FAS1	57,61	betaig-h3	72,81	FAS1	betaig-h3	355	7045	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Regulation of tumor angiogenesis by fastatin , the fourth FAS1 domain of betaig-h3 , via alphavbeta3 integrin .
23504349	0	FASL	96,100	MiR-21	0,6	FASL	MiR-21	356	406991	Gene	Gene	genes|nsubj|START_ENTITY targeting|xcomp|genes suppresses|advcl|targeting suppresses|nsubj|down-regulation down-regulation|amod|END_ENTITY	MiR-21 down-regulation suppresses cell growth , invasion and induces cell apoptosis by targeting FASL , TIMP3 , and RECK genes in esophageal_carcinoma .
22857792	0	FASLG	80,85	FAS_ligand	68,78	FASLG	FAS ligand	356	356	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Autoimmune_lymphoproliferative_syndrome caused by a homozygous null FAS_ligand -LRB- FASLG -RRB- mutation .
25966187	0	FASLG	73,78	MicroRNA-21	0,11	FASLG	MicroRNA-21	25385(Tax:10116)	100314000(Tax:10116)	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG .
17786362	0	FASN	35,39	Fatty_Acid_Synthase	14,33	FASN	Fatty Acid Synthase	2194	2194	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Fatty_Acid_Synthase -LRB- FASN -RRB- synergistically enhances the efficacy of 5-fluorouracil in breast_carcinoma cells .
22331133	0	FASN	17,21	Kr-pok	0,6	FASN	Kr-pok	14104(Tax:10090)	207259(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter .
18682402	0	FASN	111,115	fatty-acid_synthase	85,104	FASN	fatty-acid synthase	2194	2194	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Proto-oncogene FBI-1 -LRB- Pokemon -RRB- and SREBP-1 synergistically activate transcription of fatty-acid_synthase gene -LRB- FASN -RRB- .
17786030	0	FASN	68,72	fatty_acid_synthase	47,66	FASN	fatty acid synthase	2194	2194	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Caveolin-1 is required for the upregulation of fatty_acid_synthase -LRB- FASN -RRB- , a tumor promoter , during prostate_cancer progression .
10531318	0	FAST-2	97,103	Smad4	87,92	FAST-2	Smad4	8928	4089	Gene	Gene	binding|compound|START_ENTITY END_ENTITY|nmod|binding	Smad3 inhibits transforming_growth_factor-beta and activin signaling by competing with Smad4 for FAST-2 binding .
22857792	0	FAS_ligand	68,78	FASLG	80,85	FAS ligand	FASLG	356	356	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Autoimmune_lymphoproliferative_syndrome caused by a homozygous null FAS_ligand -LRB- FASLG -RRB- mutation .
8681947	0	FAT	77,80	fatty-acid_transporter	53,75	FAT	fatty-acid transporter	948	948	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and regulation of the putative membrane fatty-acid_transporter -LRB- FAT -RRB- in the small intestine .
16581652	0	FAT1	41,45	hFAT	47,51	FAT1	hFAT	2195	2195	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Immunohistological localisation of human FAT1 -LRB- hFAT -RRB- protein in 326 breast_cancers .
16574350	0	FATP-4	63,69	H-FABP	108,114	FATP-4	H-FABP	10999	2170	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Expression pattern of fatty_acid transport protein-1 -LRB- FATP-1 -RRB- , FATP-4 and heart-fatty_acid binding protein -LRB- H-FABP -RRB- genes in human term placenta .
19560442	0	FATP1	0,5	AMPK	48,52	FATP1	AMPK	376497	5563	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	FATP1 mediates fatty_acid-induced activation of AMPK in 3T3-L1 adipocytes .
21843524	0	FATP1	14,19	TR4	0,3	FATP1	TR4	376497	7182	Gene	Gene	expression|nummod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	TR4 activates FATP1 gene expression to promote lipid accumulation in 3T3-L1 adipocytes .
20843368	0	FATS	0,4	p53	36,39	FATS	p53	71007(Tax:10090)	22060(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	FATS is a transcriptional target of p53 and associated with antitumor activity .
24240685	0	FATS	0,4	p53	59,62	FATS	p53	118611	7157	Gene	Gene	ligase|nsubj|START_ENTITY ligase|acl:relcl|stabilizes stabilizes|dobj|END_ENTITY	FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage .
8099302	0	FAU	13,16	multiple_endocrine_neoplasia_type_1	24,59	FAU	multiple endocrine neoplasia type 1	2197	4221	Gene	Gene	START_ENTITY|nmod|_ _|amod|END_ENTITY	Exclusion of FAU as the multiple_endocrine_neoplasia_type_1 _ -LRB- MEN1 -RRB- _ gene .
11964310	0	FAZF	97,101	GATA-2	16,22	FAZF	GATA-2	27033	2624	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Interactions of GATA-2 with the promyelocytic_leukemia_zinc_finger -LRB- PLZF -RRB- protein , its homologue FAZF , and the t -LRB- 11 ; 17 -RRB- - generated PLZF-retinoic_acid receptor alpha oncoprotein .
24857950	0	FBI-1	0,5	ETS-1	15,20	FBI-1	ETS-1	51341	2113	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal_carcinoma cells .
26020937	0	FBI-1	12,17	ETS-1	27,32	FBI-1	ETS-1	51341	2113	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Correction : FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal_Carcinoma Cells .
11836357	0	FBLN1	20,25	fibulin-1	4,13	FBLN1	fibulin-1	2192	2192	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The fibulin-1 gene -LRB- FBLN1 -RRB- is disrupted in a t -LRB- 12 ; 22 -RRB- associated with a complex type of synpolydactyly .
7806231	0	FBLN1	20,25	fibulin-1	4,13	FBLN1	fibulin-1	2192	2192	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The fibulin-1 gene -LRB- FBLN1 -RRB- is located on human chromosome 22 and on mouse chromosome 15 .
14578376	0	FBLN3	70,75	EFEMP1	77,83	FBLN3	EFEMP1	2202	2202	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation and expression of the dominant drusen gene FBLN3 -LRB- EFEMP1 -RRB- in mammalian retina .
24917111	0	FBLN5	11,16	Fibulin-5	0,9	FBLN5	Fibulin-5	10516	10516	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Fibulin-5 -LRB- FBLN5 -RRB- gene polymorphism is associated with pelvic_organ_prolapse .
12189163	0	FBLN5	51,56	fibulin-5	40,49	FBLN5	fibulin-5	10516	10516	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Homozygosity for a missense mutation in fibulin-5 -LRB- FBLN5 -RRB- results in a severe form of cutis_laxa .
12618961	0	FBLN5	93,98	fibulin-5	82,91	FBLN5	fibulin-5	10516	10516	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic heterogeneity of cutis_laxa : a heterozygous tandem duplication within the fibulin-5 -LRB- FBLN5 -RRB- gene .
21527992	0	FBN1	83,87	COL11A1	65,72	FBN1	COL11A1	2200	1301	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	A DNA pooling-based case-control study of myopia candidate genes COL11A1 , COL18A1 , FBN1 , and PLOD1 in a Chinese population .
21527992	0	FBN1	83,87	COL18A1	74,81	FBN1	COL18A1	2200	80781	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	A DNA pooling-based case-control study of myopia candidate genes COL11A1 , COL18A1 , FBN1 , and PLOD1 in a Chinese population .
11453977	0	FBN1	13,17	Fibrillin-1	0,11	FBN1	Fibrillin-1	2200	2200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fibrillin-1 -LRB- FBN1 -RRB- gene frameshift mutations in Marfan patients : genotype-phenotype correlation .
12402346	0	FBN1	39,43	fibrillin-1	26,37	FBN1	fibrillin-1	2200	2200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation screening of the fibrillin-1 -LRB- FBN1 -RRB- gene in 76 unrelated patients with Marfan_syndrome or Marfanoid features leads to the identification of 11 novel and three previously reported mutations .
17984934	0	FBN1	122,126	fibrillin-1	109,120	FBN1	fibrillin-1	2200	2200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel non-synonymous mutation in the transforming_growth_factor_beta binding protein-like -LRB- TB -RRB- domain of the fibrillin-1 -LRB- FBN1 -RRB- gene in a Han Chinese family with Marfan_syndrome -LRB- MFS -RRB- .
19839986	0	FBN1	38,42	fibrillin-1	25,36	FBN1	fibrillin-1	2200	2200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation spectrum of the fibrillin-1 -LRB- FBN1 -RRB- gene in Taiwanese patients with Marfan_syndrome .
22950452	0	FBN1	126,130	fibrillin-1	108,119	FBN1	fibrillin-1	2200	2200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ophthalmic findings in a family with early-onset isolated_ectopia_lentis and the p.Arg62Cys mutation of the fibrillin-1 gene -LRB- FBN1 -RRB- .
8812496	0	FBNL	61,65	S1-5	50,54	FBNL	S1-5	2202	2202	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and chromosomal assignment of the human S1-5 gene -LRB- FBNL -RRB- that is highly homologous to fibrillin .
10510470	0	FBP-30	21,27	p53	44,47	FBP-30	p53	23360	7157	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	WW domain-containing FBP-30 is regulated by p53 .
14697212	0	FBP11	0,5	N-WASP	40,46	FBP11	N-WASP	55660	8976	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation .
9010133	0	FBP2	70,74	fat_body_protein_2	45,63	FBP2	fat body protein 2	34259(Tax:7227)	34259(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Selection and methionine accumulation in the fat_body_protein_2 gene -LRB- FBP2 -RRB- , a duplicate of the Drosophila alcohol_dehydrogenase -LRB- ADH -RRB- gene .
10882074	0	FBP_interacting_repressor	4,29	TFIIH	38,43	FBP interacting repressor	TFIIH	22827	2071	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The FBP_interacting_repressor targets TFIIH to inhibit activated transcription .
11165514	0	FBPase-2	6,14	PFK-2	0,5	FBPase-2	PFK-2	8789	5209	Gene	Gene	bisphosphate|nsubj|START_ENTITY END_ENTITY|appos|bisphosphate	PFK-2 / FBPase-2 : maker and breaker of the essential biofactor fructose-2 ,6 - bisphosphate .
18039179	0	FBPase-2	17,25	PFK-2	11,16	FBPase-2	PFK-2	8789	5209	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for PFK-2 / FBPase-2 , as distinct from fructose_2 ,6 - bisphosphate , in regulation of insulin secretion in pancreatic beta-cells .
15640526	0	FBW2	0,4	GCMa	13,17	FBW2	GCMa	26190	8521	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	FBW2 targets GCMa to the ubiquitin-proteasome degradation system .
23651062	0	FBW2	57,61	RACK1	0,5	FBW2	RACK1	26190	10399	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RACK1 -LRB- receptor_for_activated_C-kinase_1 -RRB- interacts with FBW2 -LRB- F-box and WD-repeat domain-containing 2 -RRB- to up-regulate GCM1 -LRB- glial_cell_missing_1 -RRB- stability and placental cell migration and invasion .
18381890	0	FBW5	13,17	TSC2	62,66	FBW5	TSC2	33854(Tax:7227)	40201(Tax:7227)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase .
22426484	0	FBW7	105,109	STAT2	25,30	FBW7	STAT2	55294	6773	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7 .
26682034	0	FBXL11	108,114	KDM2A	101,106	FBXL11	KDM2A	22992	22992	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A -LRB- FBXL11 -RRB- inhibitor .
23074094	0	FBXL11	56,62	epiregulin	17,27	FBXL11	epiregulin	22992	2069	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Demethylation of epiregulin gene by histone demethylase FBXL11 and BCL6_corepressor inhibits osteo/dentinogenic differentiation .
24390425	0	FBXL16	14,20	PP2A-B55a	27,36	FBXL16	PP2A-B55a	214931(Tax:10090)	51792(Tax:10090)	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	F-box protein FBXL16 binds PP2A-B55a and regulates differentiation of embryonic stem cells along the FLK1 + lineage .
22323446	0	FBXL2	14,19	cyclin_D2	28,37	FBXL2	cyclin D2	25827	894	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	F-box protein FBXL2 targets cyclin_D2 for ubiquitination and degradation to inhibit leukemic cell proliferation .
26790640	0	FBXL2	14,19	forkhead_box_M1	95,110	FBXL2	forkhead box M1	25827	2305	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|degradation degradation|nmod|END_ENTITY	F-box protein FBXL2 inhibits gastric_cancer proliferation by ubiquitin-mediated degradation of forkhead_box_M1 .
24778179	0	FBXL5	33,38	HERC2	0,5	FBXL5	HERC2	26234	8924	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism .
24867096	0	FBXL5	0,5	cortactin	14,23	FBXL5	cortactin	26234	2017	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric_cancer cell migration .
22113614	0	FBXO11	0,6	BCL6	15,19	FBXO11	BCL6	80204	604	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	FBXO11 targets BCL6 for degradation and is inactivated in diffuse_large_B-cell_lymphomas .
16714087	0	FBXO25	0,6	atrogin-1	38,47	FBXO25	atrogin-1	364637(Tax:10116)	171043(Tax:10116)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	FBXO25 , an F-box protein homologue of atrogin-1 , is not induced in atrophying muscle .
25944903	0	FBXO32	0,6	c-Myc	15,20	FBXO32	c-Myc	114907	4609	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity .
25944903	0	FBXO32	0,6	c-Myc	15,20	FBXO32	c-Myc	114907	4609	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity .
19581926	0	FBXO45	18,24	p73	74,77	FBXO45	p73	200933	7161	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73 .
21076392	0	FBXW7	39,44	C/EBP	22,27	FBXW7	C/EBP	55294	1050	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	The tumour suppressor C/EBP inhibits FBXW7 expression and promotes mammary tumour metastasis .
19420964	0	FBXW7	31,36	CDC4	25,29	FBXW7	CDC4	55294	55294	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Somatic mutations of the CDC4 -LRB- FBXW7 -RRB- gene in hereditary colorectal_tumors .
26097998	0	FBXW7	0,5	ENO1	27,31	FBXW7	ENO1	55294	2023	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	FBXW7 negatively regulates ENO1 expression and function in colorectal_cancer .
25669969	0	FBXW7	28,33	MYC	0,3	FBXW7	MYC	55294	4609	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MYC is a critical target of FBXW7 .
25888377	0	FBXW7	111,116	MiR-223	0,7	FBXW7	MiR-223	55294	407008	Gene	Gene	targeting|dobj|START_ENTITY regulating|advcl|targeting cells|acl|regulating resistance|nmod|cells promotes|dobj|resistance promotes|nsubj|END_ENTITY	MiR-223 promotes the cisplatin resistance of human gastric_cancer cells via regulating cell cycle by targeting FBXW7 .
25888377	0	FBXW7	111,116	MiR-223	0,7	FBXW7	MiR-223	55294	407008	Gene	Gene	targeting|dobj|START_ENTITY regulating|advcl|targeting cells|acl|regulating resistance|nmod|cells promotes|dobj|resistance promotes|nsubj|END_ENTITY	MiR-223 promotes the cisplatin resistance of human gastric_cancer cells via regulating cell cycle by targeting FBXW7 .
20861909	0	FBXW7	14,19	NOTCH1	0,6	FBXW7	NOTCH1	55294	4851	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell_acute_lymphoblastic_leukemia patients treated on DCOG or COALL protocols .
18787170	0	FBXW7	0,5	PTEN	55,59	FBXW7	PTEN	55294	5728	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression .
23228967	0	FBXW7	0,5	glucocorticoid_receptor	97,120	FBXW7	glucocorticoid receptor	55294	2908	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	FBXW7 regulates glucocorticoid response in T-cell_acute_lymphoblastic_leukaemia by targeting the glucocorticoid_receptor for degradation .
18787170	0	FBXW7	0,5	mTOR	14,18	FBXW7	mTOR	55294	21977(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression .
23857984	0	FBXW7	29,34	miR-223	66,73	FBXW7	miR-223	50754(Tax:10090)	723814(Tax:10090)	Gene	Gene	suppressor|compound|START_ENTITY targets|dobj|suppressor targets|advcl|activating activating|xcomp|END_ENTITY	The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T_cell_acute_lymphoblastic_leukemia .
24727676	0	FBXW7	52,57	miR-223	44,51	FBXW7	miR-223	55294	407008	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Notch and NF-kB signaling pathways regulate miR-223 / FBXW7 axis in T-cell_acute_lymphoblastic_leukemia .
25159729	0	FBXW7	77,82	miR-223	69,76	FBXW7	miR-223	55294	407008	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	The sensitivity of gastric_cancer to trastuzumab is regulated by the miR-223 / FBXW7 pathway .
20141544	0	FCER1A	23,29	FcepsilonRIalpha	0,16	FCER1A	FcepsilonRIalpha	2205	2205	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	FcepsilonRIalpha gene -LRB- FCER1A -RRB- promoter polymorphisms and total serum IgE levels in Japanese atopic_dermatitis patients .
26363448	0	FCGR2A	0,6	FCGR3A	8,14	FCGR2A	FCGR3A	2212	2214	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|nummod|END_ENTITY	FCGR2A , FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal antibody in metastatic colorectal_cancer .
26363448	0	FCGR3A	8,14	FCGR2A	0,6	FCGR3A	FCGR2A	2214	2212	Gene	Gene	polymorphisms|nummod|START_ENTITY END_ENTITY|appos|polymorphisms	FCGR2A , FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal antibody in metastatic colorectal_cancer .
21264533	0	FCMR	34,38	Fc_mu_receptor	18,32	FCMR	Fc mu receptor	9214	9214	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Overexpression of Fc_mu_receptor -LRB- FCMR , TOSO -RRB- gene in chronic_lymphocytic_leukemia patients .
18032536	0	FCN1	37,41	ficolin_1	21,30	FCN1	ficolin 1	2219	2219	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the ficolin_1 gene -LRB- FCN1 -RRB- are associated with susceptibility to the development of rheumatoid_arthritis .
15670829	0	FCP1	73,77	PRMT5	126,131	FCP1	PRMT5	2221	10419	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	Identification of proteins interacting with the RNAPII FCP1 phosphatase : FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation .
12138108	0	FCP1	0,4	casein_kinase_2	24,39	FCP1	casein kinase 2	398018(Tax:8355)	399320(Tax:8355)	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	FCP1 phosphorylation by casein_kinase_2 enhances binding to TFIIF and RNA polymerase II carboxyl-terminal domain phosphatase activity .
15491296	0	FCRL	22,26	FREB	28,32	FCRL	FREB	84824	84824	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of FCRL -LRB- FREB , FcRX -RRB- in normal and neoplastic human B cells .
18313765	0	FCRL3	53,58	Fc-receptor_like-3	33,51	FCRL3	Fc-receptor like-3	115352	115352	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The high producer variant of the Fc-receptor_like-3 -LRB- FCRL3 -RRB- gene is involved in protection against multiple_sclerosis .
17117947	0	FCRL3	79,84	Fc_receptor-like_3	59,77	FCRL3	Fc receptor-like 3	115352	115352	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation of the functional variant c.-169T _ > _ C of the Fc_receptor-like_3 -LRB- FCRL3 -RRB- gene in alopecia areata .
16606986	0	FCgamma_receptor_IIA	15,35	CD32	37,41	FCgamma receptor IIA	CD32	2212	2212	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of FCgamma_receptor_IIA -LRB- CD32 -RRB- polymorphism with malarial_anemia and high-density parasitemia in infants and young children .
24056087	0	FE65	0,4	ADP-ribosylation_factor_6	20,45	FE65	ADP-ribosylation factor 6	322	382	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FE65 interacts with ADP-ribosylation_factor_6 to promote neurite outgrowth .
12727304	0	FE65	75,79	APBB1	63,68	FE65	APBB1	322	322	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A risk for early-onset Alzheimer 's _ disease associated with the APBB1 gene -LRB- FE65 -RRB- intron 13 polymorphism .
18922798	0	FE65	23,27	Dexras1	0,7	FE65	Dexras1	322	51655	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription .
12358780	0	FE65	116,120	FE65L1	138,144	FE65	FE65L1	322	323	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein , FE65L1 .
12358780	0	FE65L1	138,144	FE65	116,120	FE65L1	FE65	323	322	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein , FE65L1 .
17660359	0	FEA1	0,4	FOX1	128,132	FEA1	FOX1	5719589(Tax:3055)	5720109(Tax:3055)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	FEA1 , FEA2 , and FRE1 , encoding two homologous secreted proteins and a candidate ferrireductase , are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas_reinhardtii .
1783383	0	FECH	45,49	ferrochelatase	24,38	FECH	ferrochelatase	2235	2235	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the human ferrochelatase gene -LRB- FECH -RRB- and a locus for protoporphyria to chromosome 18q22 .
12840007	0	FEN-1	32,37	CRN-1	0,5	FEN-1	CRN-1	2237	171917(Tax:6239)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	CRN-1 , a Caenorhabditis_elegans FEN-1 homologue , cooperates with CPS-6 / EndoG to promote apoptotic DNA degradation .
25774876	0	FEN-1	21,26	RECQ1	0,5	FEN-1	RECQ1	2237	5965	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin .
7673186	0	FEN-1	100,105	proliferating_cell_nuclear_antigen	109,143	FEN-1	proliferating cell nuclear antigen	2237	5111	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating_cell_nuclear_antigen .
24349332	0	FEN1	101,105	Fanconi_anemia_complementation_group_a_protein	6,52	FEN1	Fanconi anemia complementation group a protein	2237	2175	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Human Fanconi_anemia_complementation_group_a_protein stimulates the 5 ' flap endonuclease activity of FEN1 .
14562054	0	FEN1	63,67	Flap_endonuclease	44,61	FEN1	Flap endonuclease	2237	2237	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Increased expression and no mutation of the Flap_endonuclease -LRB- FEN1 -RRB- gene in human lung_cancer .
27020684	0	FEN1	63,67	flap_structure-specific_endonuclease_1	23,61	FEN1	flap structure-specific endonuclease 1	2237	2237	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Investigation of human flap_structure-specific_endonuclease_1 -LRB- FEN1 -RRB- activity on primer-template models and exploration of a substrate-based FEN1 inhibitor .
7623846	0	FER	32,35	pp120	82,87	FER	pp120	2241	3192	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors .
24244862	0	FER-1	0,5	Dysferlin	6,15	FER-1	Dysferlin	172659(Tax:6239)	26903(Tax:10090)	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	FER-1 / Dysferlin promotes cholinergic signaling at the neuromuscular junction in C. _ elegans and mice .
26556796	0	FER-LIKE_IRON_DEFICIENCY-INDUCED_TRANSCRIPTION_FACTOR	61,114	ZINC_FINGER_OF_ARABIDOPSIS_THALIANA12	0,37	FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR	ZINC FINGER OF ARABIDOPSIS THALIANA12	817362(Tax:3702)	836103(Tax:3702)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	ZINC_FINGER_OF_ARABIDOPSIS_THALIANA12 -LRB- ZAT12 -RRB- Interacts with FER-LIKE_IRON_DEFICIENCY-INDUCED_TRANSCRIPTION_FACTOR -LRB- FIT -RRB- Linking Iron_Deficiency and Oxidative Stress Responses .
19924516	0	FEZ1	0,4	CLASP2	20,26	FEZ1	CLASP2	9638	23122	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC .
23888906	0	FEZ1	45,49	Fasciculation_and_elongation_protein_zeta-1	0,43	FEZ1	Fasciculation and elongation protein zeta-1	81730(Tax:10116)	81730(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- expression in reactive astrocytes in a rat model of Parkinson 's _ disease .
19199094	0	FEZ1	59,63	fasciculation_and_elongation_protein_zeta-1	14,57	FEZ1	fasciculation and elongation protein zeta-1	81730(Tax:10116)	81730(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- in cultured rat neonatal astrocytes .
20730382	0	FEZ1	58,62	fasciculation_and_elongation_protein_zeta-1	13,56	FEZ1	fasciculation and elongation protein zeta-1	9638	9638	Gene	Gene	Functions|appos|START_ENTITY Functions|nmod|END_ENTITY	Functions of fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- in the brain .
23677067	0	FEZF2	0,5	EZH2	62,66	FEZF2	EZH2	55079	2146	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	FEZF2 , a novel 3p14 tumor suppressor gene , represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal_carcinoma .
26381015	0	FFAR1	41,46	GPR40	48,53	FFAR1	GPR40	266607(Tax:10116)	266607(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Vascular , but not luminal , activation of FFAR1 -LRB- GPR40 -RRB- stimulates GLP-1 secretion from isolated perfused rat small intestine .
26230883	0	FFAR4	51,56	GPR120	43,49	FFAR4	GPR120	338557	338557	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Biological characteristics and agonists of GPR120 -LRB- FFAR4 -RRB- receptor : the present status of research .
17532489	0	FG	33,35	fibrinogen	21,31	FG	fibrinogen	2244	2244	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Correlates of plasma fibrinogen -LRB- FG -RRB- levels in a random sample of community-dwelling elderly .
16362348	0	FGA	28,31	fibrinogen	48,58	FGA	fibrinogen	2243	2244	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Functional polymorphisms of FGA , encoding alpha fibrinogen , are associated with susceptibility to venous_thromboembolism in a Taiwanese population .
12893758	0	FGB	84,87	fibrinogen	98,108	FGB	fibrinogen	2244	2244	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Congenital_afibrinogenemia : identification and expression of a missense mutation in FGB impairing fibrinogen secretion .
15809997	0	FGD1	122,126	Aarskog-Scott_syndrome	84,106	FGD1	Aarskog-Scott syndrome	2245	2245	Gene	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	Attention-deficit/hyperactivity _ disorder -LRB- ADHD -RRB- and variable clinical expression of Aarskog-Scott_syndrome due to a novel FGD1 gene mutation -LRB- R408Q -RRB- .
15743413	0	FGD1	130,134	Cdc42	88,93	FGD1	Cdc42	2245	998	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	The FWD1/beta-TrCP-mediated degradation pathway establishes a ` turning off switch ' of a Cdc42 guanine_nucleotide exchange factor , FGD1 .
20045932	0	FGD1	138,142	Cdc42	96,101	FGD1	Cdc42	2245	998	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Proline-rich domain plays a crucial role in extracellular stimuli-responsive translocation of a Cdc42 guanine_nucleotide exchange factor , FGD1 .
10721717	0	FGD1	95,99	Faciogenital_Dysplasia	71,93	FGD1	Faciogenital Dysplasia	14163(Tax:10090)	14163(Tax:10090)	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Isolation , characterization , and mapping of the mouse Fgd3 gene , a new Faciogenital_Dysplasia -LRB- FGD1 ; Aarskog Syndrome -RRB- gene homologue .
10458911	0	FGD1	100,104	faciogenital_dysplasia	76,98	FGD1	faciogenital dysplasia	2245	2245	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation , characterization , and mapping of the mouse and human Fgd2 genes , faciogenital_dysplasia -LRB- FGD1 ; Aarskog_syndrome -RRB- gene homologues .
9268645	0	FGD1	52,56	faciogenital_dysplasia	28,50	FGD1	faciogenital dysplasia	2245	2245	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the faciogenital_dysplasia -LRB- FGD1 ; Aarskog_syndrome -RRB- gene .
19110080	0	FGD1	56,60	faciogenital_dysplasia_1	30,54	FGD1	faciogenital dysplasia 1	2245	2245	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	First case of deletion of the faciogenital_dysplasia_1 -LRB- FGD1 -RRB- gene in a patient with Aarskog-Scott_syndrome .
20043898	0	FGF	44,47	Sox3	26,30	FGF	Sox3	395432(Tax:9031)	374019(Tax:9031)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling influences the neurogenic and non-neurogenic domains in the chick otic placode .
11690635	0	FGF-1	82,87	FGF-1	95,100	FGF-1	FGF-1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	Cloning and characterization of a novel form of mouse fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- mRNA , FGF-1 .
11690635	0	FGF-1	95,100	FGF-1	82,87	FGF-1	FGF-1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	Cloning and characterization of a novel form of mouse fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- mRNA , FGF-1 .
19229075	0	FGF-1	0,5	LXRalpha	28,36	FGF-1	LXRalpha	25317(Tax:10116)	58852(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes .
10929227	0	FGF-1	39,44	fibroblast_growth_factor-1	11,37	FGF-1	fibroblast growth factor-1	2246	2246	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- on spiral_ganglion cells of the mammalian cochlea -RSB- .
11690635	0	FGF-1	82,87	fibroblast_growth_factor-1	54,80	FGF-1	fibroblast growth factor-1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Cloning and characterization of a novel form of mouse fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- mRNA , FGF-1 .
11690635	0	FGF-1	95,100	fibroblast_growth_factor-1	54,80	FGF-1	fibroblast growth factor-1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Cloning and characterization of a novel form of mouse fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- mRNA , FGF-1 .
1375939	0	FGF-1	50,55	fibroblast_growth_factor-1	22,48	FGF-1	fibroblast growth factor-1	2246	2246	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Inactivation of human fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- activity by interaction with copper_ions involves FGF-1 dimer formation induced by copper-catalyzed oxidation .
10207015	0	FGF-1	91,96	fibroblast_growth_factor_1	63,89	FGF-1	fibroblast growth factor 1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the entire transcription unit of the mouse fibroblast_growth_factor_1 -LRB- FGF-1 -RRB- gene .
15531758	0	FGF-10	0,6	SP-C	15,19	FGF-10	SP-C	2255	6440	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal_epithelium .
19410332	0	FGF-10	52,58	fibroblast_growth_factor_10	23,50	FGF-10	fibroblast growth factor 10	14165(Tax:10090)	14165(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of fibroblast_growth_factor_10 -LRB- FGF-10 -RRB- by polyoma_enhancer_activator_3 -LRB- PEA3 -RRB- .
19410332	0	FGF-10	52,58	polyoma_enhancer_activator_3	63,91	FGF-10	polyoma enhancer activator 3	14165(Tax:10090)	18612(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of fibroblast_growth_factor_10 -LRB- FGF-10 -RRB- by polyoma_enhancer_activator_3 -LRB- PEA3 -RRB- .
17498671	0	FGF-2	15,20	Akt	56,59	FGF-2	Akt	2247	207	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|acl|stimulating stimulating|dobj|END_ENTITY	Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt , ERK , and neuronal survival in hippocampal cultures .
22652804	0	FGF-2	63,68	ERK	69,72	FGF-2	ERK	14173(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	TGF-beta_1 induced fibroblast proliferation is mediated by the FGF-2 / ERK pathway .
21777817	0	FGF-2	0,5	EZH2	94,98	FGF-2	EZH2	2247	2146	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	FGF-2 regulates cell proliferation , migration , and angiogenesis through an NDY1/KDM2B-miR -101 - EZH2 pathway .
23071632	0	FGF-2	42,47	FGFR2-IIIC	17,27	FGF-2	FGFR2-IIIC	2247	2263	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation .
26120833	0	FGF-2	48,53	Fibroblast_Growth_Factor-2	20,46	FGF-2	Fibroblast Growth Factor-2	403857(Tax:9615)	403857(Tax:9615)	Gene	Gene	Mechanism|appos|START_ENTITY Mechanism|nmod|END_ENTITY	Action Mechanism of Fibroblast_Growth_Factor-2 -LRB- FGF-2 -RRB- in the Promotion of Periodontal Regeneration in Beagle_Dogs .
15963259	0	FGF-2	53,58	Fibroblast_growth_factor_2	25,51	FGF-2	Fibroblast growth factor 2	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Age-dependent changes in Fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- expression in mouse cerebellar neurons .
16720300	0	FGF-2	48,53	HD-PTP	25,31	FGF-2	HD-PTP	2247	25930	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation .
17498671	0	FGF-2	15,20	IGF-1	26,31	FGF-2	IGF-1	2247	3479	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt , ERK , and neuronal survival in hippocampal cultures .
11401402	0	FGF-2	22,27	IGF-I	0,5	FGF-2	IGF-I	14173(Tax:10090)	16000(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IGF-I synergizes with FGF-2 to stimulate oligodendrocyte progenitor entry into the cell cycle .
11485304	0	FGF-2	24,29	Interleukin-1	0,13	FGF-2	Interleukin-1	2247	3552	Gene	Gene	mRNA|compound|START_ENTITY regulates|dobj|mRNA regulates|nsubj|END_ENTITY	Interleukin-1 regulates FGF-2 mRNA and localization of FGF-2 protein in human osteoblasts .
14978743	0	FGF-2	73,78	MEKK2	0,5	FGF-2	MEKK2	14173(Tax:10090)	26405(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts .
22811469	0	FGF-2	17,22	PFKFB4	31,37	FGF-2	PFKFB4	14173(Tax:10090)	270198(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway .
18772510	0	FGF-2	11,16	Smac	57,61	FGF-2	Smac	2247	56616	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of FGF-2 on survivin and subcellular location of Smac in human small_cell_lung_cancer cell NCI-H446 -RSB- .
20150555	0	FGF-2	63,68	Sp1	71,74	FGF-2	Sp1	14173(Tax:10090)	20683(Tax:10090)	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|amod|END_ENTITY	TRAIL promotes VSMC proliferation and neointima formation in a FGF-2 - , Sp1 phosphorylation - , and NFkappaB-dependent manner .
9826564	0	FGF-2	29,34	TAXREB107	65,74	FGF-2	TAXREB107	2247	6128	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Intracellular association of FGF-2 with the ribosomal_protein_L6 / TAXREB107 .
25374926	0	FGF-2	19,24	TGF-b	0,5	FGF-2	TGF-b	14173(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	TGF-b induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways .
16148030	0	FGF-2	31,36	Thrombin	0,8	FGF-2	Thrombin	2247	2147	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells .
17968311	0	FGF-2	129,134	Thrombin	0,8	FGF-2	Thrombin	2247	2147	Gene	Gene	activity|compound|START_ENTITY control|nmod|activity mechanism|nmod|control forms|dep|mechanism cleaves|dobj|forms cleaves|nsubj|END_ENTITY	Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor -LRB- FGF-2 -RRB- : a novel mechanism for the control of FGF-2 and thrombin activity .
17968311	0	FGF-2	84,89	Thrombin	0,8	FGF-2	Thrombin	2247	2147	Gene	Gene	factor|appos|START_ENTITY forms|nmod|factor cleaves|dobj|forms cleaves|nsubj|END_ENTITY	Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor -LRB- FGF-2 -RRB- : a novel mechanism for the control of FGF-2 and thrombin activity .
12428103	0	FGF-2	123,128	VEGF	170,174	FGF-2	VEGF	2247	7422	Gene	Gene	fibroblast_growth_factor-2|appos|START_ENTITY fibroblast_growth_factor-2|appos|END_ENTITY	Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
15078481	0	FGF-2	93,98	VEGF	44,48	FGF-2	VEGF	14173(Tax:10090)	22339(Tax:10090)	Gene	Gene	substitute|nmod|START_ENTITY acts|nmod|substitute acts|amod|END_ENTITY	Liver_regeneration in FGF-2-deficient mice : VEGF acts as potential functional substitute for FGF-2 .
15367264	0	FGF-2	178,183	VEGF	93,97	FGF-2	VEGF	281161(Tax:9913)	281572(Tax:9913)	Gene	Gene	factor|nmod|START_ENTITY factor|dep|END_ENTITY	Expression pattern of fibroblast growth factor -LRB- FGF -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- system members in bovine corpus luteum endothelial cells during treatment with FGF-2 , VEGF or oestradiol .
18948122	0	FGF-2	15,20	VEGF	0,4	FGF-2	VEGF	281161(Tax:9913)	281572(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	VEGF regulates FGF-2 and TGF-beta1 expression in injury endothelial cells and mediates smooth muscle cells proliferation and migration .
9647657	0	FGF-2	28,33	VEGF	79,83	FGF-2	VEGF	14173(Tax:10090)	22339(Tax:10090)	Gene	Gene	Fibroblast_growth_factor-2|appos|START_ENTITY induces|nsubj|Fibroblast_growth_factor-2 induces|dobj|expression expression|appos|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the endothelial cells of forming capillaries : an autocrine mechanism contributing to angiogenesis .
8375342	0	FGF-2	25,30	bFGF	32,36	FGF-2	bFGF	396413(Tax:9031)	396413(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Retroviral expression of FGF-2 -LRB- bFGF -RRB- affects patterning in chick limb bud .
22895673	0	FGF-2	54,59	basic_Fibroblast_Growth_Factor	22,52	FGF-2	basic Fibroblast Growth Factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dynamic modulation of basic_Fibroblast_Growth_Factor -LRB- FGF-2 -RRB- expression in the rat brain following repeated exposure to cocaine during adolescence .
14630795	0	FGF-2	42,47	fibrinogen	52,62	FGF-2	fibrinogen	2247	2244	Gene	Gene	site|nmod|START_ENTITY Identification|nmod|site Identification|nmod|END_ENTITY	Identification of a binding site on human FGF-2 for fibrinogen .
15297314	0	FGF-2	49,54	fibrinogen	74,84	FGF-2	fibrinogen	2247	2244	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3 .
12058341	0	FGF-2	43,48	fibroblast_growth_factor	17,41	FGF-2	fibroblast growth factor	2247	2247	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- on proliferation of human skin fibroblasts in type_II_diabetes_mellitus .
7898570	0	FGF-2	52,57	fibroblast_growth_factor	26,50	FGF-2	fibroblast growth factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	The localization of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- in rat submandibular glands .
8072023	0	FGF-2	67,72	fibroblast_growth_factor	41,65	FGF-2	fibroblast growth factor	403857(Tax:9615)	403857(Tax:9615)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Longitudinal changes in myocardial basic fibroblast_growth_factor -LRB- FGF-2 -RRB- activity following coronary artery ligation in the dog .
8397111	0	FGF-2	51,56	fibroblast_growth_factor	25,49	FGF-2	fibroblast growth factor	2247	2247	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- in the nuclei of SK-Hep-1 cells .
9293890	0	FGF-2	46,51	fibroblast_growth_factor	20,44	FGF-2	fibroblast growth factor	2247	2247	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- - associated with tumour proliferation in human pancreatic_carcinoma .
11075807	0	FGF-2	132,137	fibroblast_growth_factor-2	5,31	FGF-2	fibroblast growth factor-2	2247	2247	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FIF -LSB- fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- - interacting-factor -RSB- , a nuclear putatively antiapoptotic factor , interacts specifically with FGF-2 .
15875782	0	FGF-2	93,98	fibroblast_growth_factor-2	65,91	FGF-2	fibroblast growth factor-2	2247	2247	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Influence of hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- on fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- levels in external auditory canal cholesteatoma -LRB- EACC -RRB- cell culture .
15957346	0	FGF-2	50,55	fibroblast_growth_factor-2	22,48	FGF-2	fibroblast growth factor-2	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- during embryonic development of the rat submandibular gland .
8714368	0	FGF-2	40,45	fibroblast_growth_factor-2	12,38	FGF-2	fibroblast growth factor-2	2247	2247	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- in hematopoiesis .
9582440	0	FGF-2	118,123	fibroblast_growth_factor-2	90,116	FGF-2	fibroblast growth factor-2	281161(Tax:9913)	281161(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Increased tyrosine phosphorylation and novel cis-acting element mediate activation of the fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- gene by nicotinic acetylcholine receptor .
10809367	0	FGF-2	53,58	fibroblast_growth_factor_2	25,51	FGF-2	fibroblast growth factor 2	2247	2247	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cellular localization of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- in benign_prostatic_hyperplasia .
16412094	0	FGF-2	50,55	fibroblast_growth_factor_2	22,48	FGF-2	fibroblast growth factor 2	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Dynamic regulation of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- gene expression in the rat brain following single and repeated cocaine administration .
20581332	0	FGF-2	56,61	fibroblast_growth_factor_2	28,54	FGF-2	fibroblast growth factor 2	2247	2247	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and functions of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- in hippocampal formation .
9558385	0	FGF-2	56,61	fibroblast_growth_factor_2	28,54	FGF-2	fibroblast growth factor 2	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Platelet_factor_4 modulates fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- activity and inhibits FGF-2 dimerization .
9681690	0	FGF-2	44,49	fibroblast_growth_factor_2	16,42	FGF-2	fibroblast growth factor 2	2247	2247	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Localization of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- protein and the receptors FGFR_1-4 in normal human seminiferous epithelium .
16405079	0	FGF-2	23,28	insulin	34,41	FGF-2	insulin	2247	3630	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes .
9215712	0	FGF-2	0,5	nerve_growth_factor	14,33	FGF-2	nerve growth factor	54250(Tax:10116)	310738(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	FGF-2 induces nerve_growth_factor expression in cultured rat hippocampal neurons .
15333041	0	FGF-2	31,36	u-PA	72,76	FGF-2	u-PA	2247	5328	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA , u-PAR , and PAI-1 in endothelial cells .
23873427	0	FGF-21	47,53	fibroblast_growth_factor-21	18,45	FGF-21	fibroblast growth factor-21	26291	26291	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes of plasma fibroblast_growth_factor-21 -LRB- FGF-21 -RRB- in oral glucose tolerance test and effects of metformin on FGF-21 levels in type_2_diabetes_mellitus .
24019880	0	FGF-23	0,6	CYP27B1	17,24	FGF-23	CYP27B1	64654(Tax:10090)	13115(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues .
22099949	0	FGF-23	0,6	cardiac_troponin_T	26,44	FGF-23	cardiac troponin T	8074	7139	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	FGF-23 is associated with cardiac_troponin_T and mortality in hemodialysis patients .
20813767	0	FGF-23	35,41	fibroblast_growth_factor-23	6,33	FGF-23	fibroblast growth factor-23	8074	8074	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum fibroblast_growth_factor-23 -LRB- FGF-23 -RRB- levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients .
16751688	2	FGF-23	149,155	fibroblast_growth_factor_23	120,147	FGF-23	fibroblast growth factor 23	8074	8074	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	The measurement of circulating fibroblast_growth_factor_23 -LRB- FGF-23 -RRB- -RSB- .
11445874	0	FGF-3	29,34	int-2	23,28	FGF-3	int-2	2248	2248	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Detection of amplified int-2 / FGF-3 gene in primary breast_carcinomas using differential polymerase chain reaction .
1425349	0	FGF-3	47,52	int-2	40,45	FGF-3	int-2	373669(Tax:8355)	373669(Tax:8355)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Developmental expression of the Xenopus int-2 -LRB- FGF-3 -RRB- gene : activation by mesodermal and neural induction .
7506139	0	FGF-4	0,5	Evx-1	30,35	FGF-4	Evx-1	14175(Tax:10090)	14028(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	FGF-4 regulates expression of Evx-1 in the developing mouse limb .
15116099	0	FGF-4	6,11	HST-1	0,5	FGF-4	HST-1	14175(Tax:10090)	109727(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|appos|plays	HST-1 / FGF-4 plays a critical role in crypt cell survival and facilitates epithelial cell restitution and proliferation .
7635948	0	FGF-4	94,99	HST-1	87,92	FGF-4	HST-1	14175(Tax:10090)	109727(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 -LRB- FGF-4 -RRB- gene .
21544372	0	FGF-4	46,51	fibroblast_growth_factor_4	18,44	FGF-4	fibroblast growth factor 4	2249	2249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the fibroblast_growth_factor_4 -LRB- FGF-4 -RRB- gene is regulated by serum in Tera-2 embryonal_carcinoma cells .
11114518	0	FGF-8	0,5	FGFR-4a	50,57	FGF-8	FGFR-4a	399183(Tax:8355)	397701(Tax:8355)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	FGF-8 stimulates neuronal differentiation through FGFR-4a and interferes with mesoderm induction in Xenopus embryos .
7980556	0	FGF-8	47,52	androgen-induced_growth_factor	15,45	FGF-8	androgen-induced growth factor	14179(Tax:10090)	14179(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Involvement of androgen-induced_growth_factor -LRB- FGF-8 -RRB- gene in mouse embryogenesis and morphogenesis .
10842056	0	FGF-8	50,55	fibroblast_growth_factor-8	22,48	FGF-8	fibroblast growth factor-8	396313(Tax:9031)	396313(Tax:9031)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Multiple functions of fibroblast_growth_factor-8 -LRB- FGF-8 -RRB- in chick eye development .
16412577	0	FGF-BP	93,99	fibroblast_growth_factor-binding_protein	51,91	FGF-BP	fibroblast growth factor-binding protein	281812(Tax:9913)	281812(Tax:9913)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Purification and biochemical characterization of a fibroblast_growth_factor-binding_protein -LRB- FGF-BP -RRB- from the lactoferrin fraction of bovine milk .
20189986	0	FGF1	14,18	RFX1	62,66	FGF1	RFX1	2246	5989	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of FGF1 gene promoter through transcription factor RFX1 .
17460766	0	FGF1	14,18	aFGF	20,24	FGF1	aFGF	25317(Tax:10116)	25317(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Comparison of FGF1 -LRB- aFGF -RRB- expression between the dorsal motor nucleus of vagus and the hypoglossal nucleus of rat .
16801131	0	FGF1	19,23	fibroblast_growth_factor_receptor_3	34,69	FGF1	fibroblast growth factor receptor 3	2246	2261	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Reduced binding of FGF1 to mutant fibroblast_growth_factor_receptor_3 .
16838370	0	FGF10	14,19	Brn3a	48,53	FGF10	Brn3a	14165(Tax:10090)	18996(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of FGF10 by POU transcription factor Brn3a in the developing trigeminal ganglion .
10646796	0	FGF10	0,5	En1	52,55	FGF10	En1	395432(Tax:9031)	771008(Tax:9031)	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|END_ENTITY	FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm , independent of its dorsoventral specification .
10646796	0	FGF10	0,5	Fgf8	17,21	FGF10	Fgf8	395432(Tax:9031)	396313(Tax:9031)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm , independent of its dorsoventral specification .
22303449	0	FGF10	24,29	ISL1	0,4	FGF10	ISL1	2255	3670	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	ISL1 directly regulates FGF10 transcription during human cardiac outflow formation .
21518765	0	FGF12	29,34	Fibroblast_growth_factor-12	0,27	FGF12	Fibroblast growth factor-12	170630(Tax:10116)	170630(Tax:10116)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Fibroblast_growth_factor-12 -LRB- FGF12 -RRB- translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain : involvement of internalization in the in vivo role of exogenous FGF12 .
26230950	0	FGF13	0,5	Spry1	88,93	FGF13	Spry1	14168(Tax:10090)	24063(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating Spry1 .
15252029	0	FGF18	0,5	noggin	16,22	FGF18	noggin	8817	9241	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	FGF18 represses noggin expression and is induced by calcineurin .
22267484	0	FGF19	0,5	APOA	35,39	FGF19	APOA	9965	335	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	FGF19 signaling cascade suppresses APOA gene expression .
22020932	0	FGF19	52,57	Klotho_beta	40,51	FGF19	Klotho beta	9965	152831	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Short hairpin RNA screen indicates that Klotho_beta / FGF19 protein overcomes stasis in human colonic epithelial cells .
24248542	0	FGF19	34,39	fibroblast_growth_factor_19	5,32	FGF19	fibroblast growth factor 19	9965	9965	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	High fibroblast_growth_factor_19 -LRB- FGF19 -RRB- expression predicts worse prognosis in invasive_ductal_carcinoma of breast .
23331079	0	FGF2	80,84	AP-1	47,51	FGF2	AP-1	2247	3726	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Interleukin-1b enhances cell migration through AP-1 and NF-kB pathway-dependent FGF2 expression in human corneal endothelial cells .
12430142	0	FGF2	37,41	Androgen_receptor	0,17	FGF2	Androgen receptor	2247	367	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|expression expression|amod|END_ENTITY	Androgen_receptor expression induces FGF2 , FGF-binding_protein production , and FGF2 release in prostate_carcinoma cells : role of FGF2 in growth , survival , and androgen_receptor down-modulation .
16222707	0	FGF2	93,97	CD133	13,18	FGF2	CD133	2247	8842	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Unique human CD133 + leukemia cell line and its modulation towards a mesenchymal phenotype by FGF2 and TGFbeta1 .
22198237	0	FGF2	67,71	Egr-1	61,66	FGF2	Egr-1	2247	1958	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	MG624 , an a7-nAChR antagonist , inhibits angiogenesis via the Egr-1 / FGF2 pathway .
20460816	0	FGF2	0,4	Grb2	41,45	FGF2	Grb2	2247	2885	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	FGF2 induces ERK phosphorylation through Grb2 and PKC during quiescent myogenic cell activation .
18728783	0	FGF2	0,4	HIF-1alpha	97,107	FGF2	HIF-1alpha	2247	3091	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha .
26549747	0	FGF2	34,38	Insulin	0,7	FGF2	Insulin	2247	3630	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Insulin induces the expression of FGF2 but does not synergize with it during angiogenesis .
25190353	0	FGF2	79,83	MiR-152	0,7	FGF2	MiR-152	2247	406943	Gene	Gene	inhibiting|dobj|START_ENTITY suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2 .
21806973	0	FGF2	70,74	PTH	37,40	FGF2	PTH	14173(Tax:10090)	19226(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression .
24249810	0	FGF2	0,4	RANKL	13,18	FGF2	RANKL	2247	8600	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	FGF2 induces RANKL gene expression as well as IL1b regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells .
19301256	0	FGF2	0,4	SDF-1	16,21	FGF2	SDF-1	14173(Tax:10090)	20315(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells .
17077327	0	FGF2	0,4	SDF1	56,60	FGF2	SDF1	2247	6387	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc .
10940627	0	FGF2	21,25	SPRY2	6,11	FGF2	SPRY2	2247	10253	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Human SPRY2 inhibits FGF2 signalling by a secreted factor .
21118521	0	FGF2	81,85	ccp1	73,77	FGF2	ccp1	2247	84317	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1 , a FGF2 downstream gene .
20371606	0	FGF2	56,60	endothelial_nitric-oxide_synthase	114,147	FGF2	endothelial nitric-oxide synthase	2247	4846	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Activation of AP-1 transcription factors differentiates FGF2 and vascular_endothelial_growth_factor regulation of endothelial_nitric-oxide_synthase expression in placental artery endothelial cells .
19586755	0	FGF2	42,46	fibroblast_growth_factor	16,40	FGF2	fibroblast growth factor	2247	2247	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effect of basic fibroblast_growth_factor -LRB- FGF2 -RRB- gene polymorphisms on SSRIs treatment response and side effects .
18487671	0	FGF2	50,54	fibroblast_growth_factor_2	22,48	FGF2	fibroblast growth factor 2	281161(Tax:9913)	281161(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of bovine fibroblast_growth_factor_2 -LRB- FGF2 -RRB- gene with milk fat and productive life : an example of the ability of the candidate pathway strategy to identify quantitative trait genes .
22342445	0	FGF20	29,34	Fibroblast_growth_factor_20	0,27	FGF20	Fibroblast growth factor 20	26281	26281	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Fibroblast_growth_factor_20 -LRB- FGF20 -RRB- polymorphism is a risk factor for Parkinson 's _ disease in Chinese population .
24942208	0	FGF20	29,34	Fibroblast_growth_factor_20	0,27	FGF20	Fibroblast growth factor 20	26281	26281	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fibroblast_growth_factor_20 -LRB- FGF20 -RRB- gene polymorphism and risk of Parkinson 's _ disease : a meta-analysis .
18252210	0	FGF20	43,48	miRNA-433	17,26	FGF20	miRNA-433	26281	574034	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson_disease by overexpression of alpha-synuclein .
24041694	0	FGF21	78,83	ATF4	99,103	FGF21	ATF4	26291	468	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|activation activation|compound|END_ENTITY	Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation .
24900988	0	FGF21	38,43	ATF4	0,4	FGF21	ATF4	26291	468	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	ATF4 - and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress .
25215270	0	FGF21	0,5	FGF21	40,45	FGF21	FGF21	26291	26291	Gene	Gene	START_ENTITY|dep|Roles Roles|nmod|END_ENTITY	FGF21 as a Stress Hormone : The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic_Diseases .
25215270	0	FGF21	40,45	FGF21	0,5	FGF21	FGF21	26291	26291	Gene	Gene	Roles|nmod|START_ENTITY END_ENTITY|dep|Roles	FGF21 as a Stress Hormone : The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic_Diseases .
26133178	0	FGF21	37,42	Fibroblast_Growth_Factor_21	8,35	FGF21	Fibroblast Growth Factor 21	56636(Tax:10090)	56636(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Fibroblast_Growth_Factor_21 -LRB- FGF21 -RRB- in the regulation of statural growth .
21926274	0	FGF21	91,96	Fibroblast_growth_factor_21	0,27	FGF21	Fibroblast growth factor 21	26291	26291	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Fibroblast_growth_factor_21 -LRB- FGF21 -RRB- in human cerebrospinal fluid : relationship with plasma FGF21 and body adiposity .
22778214	0	FGF21	106,111	JNK1	94,98	FGF21	JNK1	56636(Tax:10090)	26419(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	TNF-a represses b-Klotho expression and impairs FGF21 action in adipose cells : involvement of JNK1 in the FGF21 pathway .
21852674	0	FGF21	15,20	Nrf2	0,4	FGF21	Nrf2	56636(Tax:10090)	18024(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice .
22302939	0	FGF21	0,5	PGC-1a	16,22	FGF21	PGC-1a	56636(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	FGF21 regulates PGC-1a and browning of white_adipose_tissues in adaptive thermogenesis .
19541642	0	FGF21	0,5	PGC-1alpha	14,24	FGF21	PGC-1alpha	56636(Tax:10090)	19017(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	FGF21 induces PGC-1alpha and regulates carbohydrate and fatty_acid metabolism during the adaptive starvation response .
20018698	0	FGF21	40,45	PGC-1alpha	0,10	FGF21	PGC-1alpha	56636(Tax:10090)	19017(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb -LRB- alpha -RRB- axis .
17601491	0	FGF21	40,45	PPARalpha	0,9	FGF21	PPARalpha	26291	5465	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PPARalpha is a key regulator of hepatic FGF21 .
18840432	0	FGF21	24,29	PPARalpha	44,53	FGF21	PPARalpha	56636(Tax:10090)	19013(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induced|nsubjpass|expression induced|nmod|activation activation|compound|END_ENTITY	Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver .
20197053	0	FGF21	8,13	PPARalpha	49,58	FGF21	PPARalpha	56636(Tax:10090)	19013(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induced|nsubjpass|expression induced|nmod|birth birth|nmod|END_ENTITY	Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat .
24848261	0	FGF21	0,5	dynamin-2	55,64	FGF21	dynamin-2	26291	1785	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|amod|END_ENTITY	FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway .
19531026	0	FGF21	41,46	fibroblast_growth_factor_21	12,39	FGF21	fibroblast growth factor 21	56636(Tax:10090)	56636(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of fibroblast_growth_factor_21 -LRB- FGF21 -RRB- on energy balance , glucose and lipid metabolism .
22374976	0	FGF21	37,42	fibroblast_growth_factor_21	8,35	FGF21	fibroblast growth factor 21	56636(Tax:10090)	56636(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of fibroblast_growth_factor_21 -LRB- FGF21 -RRB- in undernutrition-related attenuation of growth in mice .
22701542	0	FGF21	54,59	fibroblast_growth_factor_21	25,52	FGF21	fibroblast growth factor 21	26291	26291	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Exercise increases serum fibroblast_growth_factor_21 -LRB- FGF21 -RRB- levels .
25082895	0	FGF21	91,96	mTORC1	8,14	FGF21	mTORC1	26291	382056(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Hepatic mTORC1 controls locomotor activity , body temperature , and lipid metabolism through FGF21 .
20332535	0	FGF21	14,19	retinoic_acid_receptor-related_orphan_receptor_alpha	48,100	FGF21	retinoic acid receptor-related orphan receptor alpha	26291	6095	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of FGF21 expression and secretion by retinoic_acid_receptor-related_orphan_receptor_alpha .
24402093	0	FGF23	20,25	FGF23	64,69	FGF23	FGF23	170583(Tax:10116)	170583(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney_disease .
24402093	0	FGF23	64,69	FGF23	20,25	FGF23	FGF23	170583(Tax:10116)	170583(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney_disease .
22933546	0	FGF23	52,57	fibroblast_growth_factor-23	23,50	FGF23	fibroblast growth factor-23	8074	8074	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Frequent expression of fibroblast_growth_factor-23 -LRB- FGF23 -RRB- mRNA in aneurysmal_bone_cysts and chondromyxoid_fibromas .
19483276	1	FGF23	128,133	fibroblast_growth_factor_23	99,126	FGF23	fibroblast growth factor 23	8074	8074	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	Clinical usefulness of measurement of fibroblast_growth_factor_23 -LRB- FGF23 -RRB- -RSB- .
23146451	0	FGF23	37,42	fibroblast_growth_factor_23	8,35	FGF23	fibroblast growth factor 23	8074	8074	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of fibroblast_growth_factor_23 -LRB- FGF23 -RRB- in the metabolism of phosphorus and calcium immediately after kidney transplantation .
25700720	0	FGF23	41,46	fibroblast_growth_factor_23	12,39	FGF23	fibroblast growth factor 23	8074	8074	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating fibroblast_growth_factor_23 -LRB- FGF23 -RRB- levels are associated with metabolic disturbances and fat distribution but not cardiovascular risk in HIV-infected patients .
22145450	0	FGF23	18,23	growth_hormone	27,41	FGF23	growth hormone	8074	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Changes in plasma FGF23 in growth_hormone deficient children during rhGH therapy .
15885032	0	FGF23	34,39	vitamin_D_receptor	12,30	FGF23	vitamin D receptor	64654(Tax:10090)	22337(Tax:10090)	Gene	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Role of the vitamin_D_receptor in FGF23 action on phosphate metabolism .
20553903	0	FGF3	113,117	Krox20	139,145	FGF3	Krox20	396267(Tax:9031)	107053633	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Analysis of expression and function of FGF-MAPK signaling components in the hindbrain reveals a central role for FGF3 in the regulation of Krox20 , mediated by Pea3 .
7809043	0	FGF4	43,47	HST-1	36,41	FGF4	HST-1	14175(Tax:10090)	109727(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Adenovirus-mediated transfer of the HST-1 -LRB- FGF4 -RRB- gene induces increased levels of platelet count in vivo .
20084082	0	FGF4	95,99	KIAA1718	37,45	FGF4	KIAA1718	2249	338523(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Dual-specificity histone demethylase KIAA1718 -LRB- KDM7A -RRB- regulates neural differentiation through FGF4 .
8199350	0	FGF6	48,52	fibroblast_growth_factor_6	20,46	FGF6	fibroblast growth factor 6	14177(Tax:10090)	14177(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	The human and mouse fibroblast_growth_factor_6 -LRB- FGF6 -RRB- genes and their products : possible implication in muscle development .
9878802	0	FGF6	48,52	fibroblast_growth_factor_6	20,46	FGF6	fibroblast growth factor 6	2251	2251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a fibroblast_growth_factor_6 -LRB- FGF6 -RRB- gene in a non-mammalian vertebrate : continuous expression of FGF6 accompanies muscle fiber hyperplasia .
26508592	0	FGF7	22,26	KGF	28,31	FGF7	KGF	2252	2252	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of FGF7 -LRB- KGF -RRB- in the regenerating tail of lizard suggests it is involved in the differentiation of the epidermis .
23399805	0	FGF8	56,60	AREG	50,54	FGF8	AREG	2253	374	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|compound|END_ENTITY	Cytomegalovirus-induced salivary gland pathology : AREG , FGF8 , TNF-a , and IL-6_signal_dysregulation and neoplasia .
11807898	0	FGF8	152,156	EN1	142,145	FGF8	EN1	2253	2019	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Search for genes involved in Joubert_syndrome : evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1 , EN2 , FGF8 , and BARHL1 .
11807898	0	FGF8	152,156	EN2	147,150	FGF8	EN2	2253	2020	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Search for genes involved in Joubert_syndrome : evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1 , EN2 , FGF8 , and BARHL1 .
8595889	0	FGF8	14,18	FGF8	63,67	FGF8	FGF8	2253	2253	Gene	Gene	START_ENTITY|dep|mutations mutations|nmod|END_ENTITY	Assignment of FGF8 to human chromosome 10q25-q26 : mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region .
8595889	0	FGF8	63,67	FGF8	14,18	FGF8	FGF8	2253	2253	Gene	Gene	mutations|nmod|START_ENTITY END_ENTITY|dep|mutations	Assignment of FGF8 to human chromosome 10q25-q26 : mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region .
10518499	0	FGF8	0,4	Gbx2	18,22	FGF8	Gbx2	14179(Tax:10090)	14472(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate .
12766772	0	FGF8	39,43	MKP3	0,4	FGF8	MKP3	14179(Tax:10090)	67603(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb .
12140757	0	FGF8	14,18	androgen_receptor	37,54	FGF8	androgen receptor	2253	367	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of FGF8 expression by the androgen_receptor in human prostate_cancer .
18699993	0	FGF8	36,40	fibroblast_growth_factor_8	8,34	FGF8	fibroblast growth factor 8	29349(Tax:10116)	29349(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of fibroblast_growth_factor_8 -LRB- FGF8 -RRB- in animal models of osteoarthritis .
22798350	0	FGF9	39,43	fibroblast_growth_factor_9	11,37	FGF9	fibroblast growth factor 9	613731(Tax:9913)	613731(Tax:9913)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of fibroblast_growth_factor_9 -LRB- FGF9 -RRB- on steroidogenesis and gene expression and control of FGF9 mRNA in bovine granulosa cells .
22917588	0	FGF9	71,75	miR-182	0,7	FGF9	miR-182	25444(Tax:10116)	100314172(Tax:10116)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM , respectively at an early stage following sciatic nerve_injury .
25429350	0	FGFBP1	69,75	Fibroblast_Growth_Factor_Binding_Protein-1	25,67	FGFBP1	Fibroblast Growth Factor Binding Protein-1	9982	9982	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of a Secreted Fibroblast_Growth_Factor_Binding_Protein-1 -LRB- FGFBP1 -RRB- in Angioproliferative Kaposi_Sarcoma .
23111653	0	FGFR	10,14	FGFR	73,77	FGFR	FGFR	39564(Tax:7227)	39564(Tax:7227)	Gene	Gene	replaces|nsubj|START_ENTITY replaces|dobj|END_ENTITY	The Hydra FGFR , Kringelchen , partially replaces the Drosophila Heartless FGFR .
23111653	0	FGFR	73,77	FGFR	10,14	FGFR	FGFR	39564(Tax:7227)	39564(Tax:7227)	Gene	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	The Hydra FGFR , Kringelchen , partially replaces the Drosophila Heartless FGFR .
9274456	0	FGFR-1	69,75	basic_fibroblast_growth_factor	20,50	FGFR-1	basic fibroblast growth factor	2260	2247	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of basic_fibroblast_growth_factor and its receptor -LRB- FGFR-1 -RRB- in patients with non-small_cell_lung_carcinomas .
9021547	0	FGFR-1	119,125	fibroblast_growth_factor-1	36,62	FGFR-1	fibroblast growth factor-1	2260	2246	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- , FGF-2 and fibroblast_growth_factor_receptor-1 -LRB- FGFR-1 -RRB- in pleomorphic_adenoma of the salivary glands .
1437152	0	FGFR-1	55,61	fibroblast_growth_factor_receptor_1	18,53	FGFR-1	fibroblast growth factor receptor 1	2260	2260	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inhibition of the fibroblast_growth_factor_receptor_1 -LRB- FGFR-1 -RRB- gene in human melanocytes and malignant_melanomas leads to inhibition of proliferation and signs indicative of differentiation .
1321062	0	FGFR-1	52,58	flg	59,62	FGFR-1	flg	14182(Tax:10090)	14246(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of the fibroblast growth factor receptor FGFR-1 / flg during gastrulation and segmentation in the mouse embryo .
17875810	0	FGFR-1	0,6	interleukin-4	48,61	FGFR-1	interleukin-4	2260	3565	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin .
10739663	0	FGFR-2	51,57	fibroblast_growth_factor_receptor-2	14,49	FGFR-2	fibroblast growth factor receptor-2	2263	2263	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The Ser252Trp fibroblast_growth_factor_receptor-2 -LRB- FGFR-2 -RRB- mutation induces PKC-independent downregulation of FGFR-2 associated with premature calvaria osteoblast differentiation .
16856175	0	FGFR-2	57,63	fibroblast_growth_factor_receptor_2	20,55	FGFR-2	fibroblast growth factor receptor 2	25022(Tax:10116)	25022(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Cytoarchitecture of fibroblast_growth_factor_receptor_2 -LRB- FGFR-2 -RRB- immunoreactivity in astrocytes of neurogenic and non-neurogenic regions of the young adult and aged rat brain .
1662791	0	FGFR-3	89,95	fibroblast_growth_factor_receptor_3	52,87	FGFR-3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Structural and biosynthetic characterization of the fibroblast_growth_factor_receptor_3 -LRB- FGFR-3 -RRB- protein .
11114518	0	FGFR-4a	50,57	FGF-8	0,5	FGFR-4a	FGF-8	397701(Tax:8355)	399183(Tax:8355)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	FGF-8 stimulates neuronal differentiation through FGFR-4a and interferes with mesoderm induction in Xenopus embryos .
14766059	0	FGFR1	23,28	Bcl-2	30,35	FGFR1	Bcl-2	2260	596	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	-LSB- The response of bFGF , FGFR1 , Bcl-2 and caspase-3 to visible light in cultured human retinal pigment epithelium cells -RSB- .
26420260	0	FGFR1	16,21	Cdh2	0,4	FGFR1	Cdh2	14182(Tax:10090)	12558(Tax:10090)	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells .
16807070	0	FGFR1	10,15	FGFR1	39,44	FGFR1	FGFR1	2260	2260	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Recurrent FGFR1 amplification and high FGFR1 protein expression in oral_squamous_cell_carcinoma -LRB- OSCC -RRB- .
16807070	0	FGFR1	39,44	FGFR1	10,15	FGFR1	FGFR1	2260	2260	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Recurrent FGFR1 amplification and high FGFR1 protein expression in oral_squamous_cell_carcinoma -LRB- OSCC -RRB- .
14695195	0	FGFR1	28,33	FGFR2	52,57	FGFR1	FGFR2	14182(Tax:10090)	14183(Tax:10090)	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|END_ENTITY	Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic_intraepithelial_neoplasia in the mouse prostate .
24026051	0	FGFR1	63,68	FGFRL1	33,39	FGFR1	FGFRL1	14182(Tax:10090)	116701(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1 .
27015635	0	FGFR1	59,64	Fibroblast_Growth_Factor_Receptor_1	22,57	FGFR1	Fibroblast Growth Factor Receptor 1	79114(Tax:10116)	79114(Tax:10116)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the Fibroblast_Growth_Factor_Receptor_1 -LRB- FGFR1 -RRB- in a Model of Spinal_Cord_Injury in Rats .
17901128	0	FGFR1	37,42	Fibroblast_growth_factor_receptor_1	0,35	FGFR1	Fibroblast growth factor receptor 1	2260	2260	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Fibroblast_growth_factor_receptor_1 -LRB- FGFR1 -RRB- tyrosine phosphorylation regulates binding of FGFR_substrate_2alpha -LRB- FRS2alpha -RRB- but not FRS2 to the receptor .
26096068	0	FGFR1	18,23	LMP1	77,81	FGFR1	LMP1	2260	9260	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Activation of the FGFR1 signalling pathway by the Epstein-Barr_virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells .
26872365	0	FGFR1	86,91	MiR-214	0,7	FGFR1	MiR-214	14182(Tax:10090)	387210(Tax:10090)	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1 .
21765395	0	FGFR1	42,47	Nedd4-1	0,7	FGFR1	Nedd4-1	2260	4734	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function .
20389169	0	FGFR1	24,29	SOS1	31,35	FGFR1	SOS1	2260	6654	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of FGFR1 , SOS1 , RAF1 genes in cryptorchidism .
22569333	0	FGFR1	21,26	Syndecan_4	0,10	FGFR1	Syndecan 4	2260	6385	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Syndecan_4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis .
26557159	0	FGFR1	65,70	fibroblast_growth_factor_receptor_1	28,63	FGFR1	fibroblast growth factor receptor 1	2260	2260	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutation detection of fibroblast_growth_factor_receptor_1 -LRB- FGFR1 -RRB- gene , FGFR2IIIa , FGFR2IIIb , FGFR2IIIc , FGFR3 , FGFR4 gene for craniosynostosis : A prospective study in Asian Indian patient .
9286594	0	FGFR1	50,55	fibroblast_growth_factor_receptors	14,48	FGFR1	fibroblast growth factor receptors	2260	2260	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of fibroblast_growth_factor_receptors -LRB- FGFR1 , FGFR2 , FGFR3 -RRB- in the developing head and face .
11704499	0	FGFR1	83,88	fibroblast_growth_factor_type_I_receptor	41,81	FGFR1	fibroblast growth factor type I receptor	79114(Tax:10116)	79114(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Spatial and temporal gene expression for fibroblast_growth_factor_type_I_receptor -LRB- FGFR1 -RRB- during fracture healing in the rat .
14695195	0	FGFR2	52,57	FGFR1	28,33	FGFR2	FGFR1	14183(Tax:10090)	14182(Tax:10090)	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|END_ENTITY	Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic_intraepithelial_neoplasia in the mouse prostate .
19735729	0	FGFR2	37,42	Grb2	18,22	FGFR2	Grb2	2263	2885	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function .
25788520	0	FGFR2	0,5	Mre11	16,21	FGFR2	Mre11	2263	4361	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis .
10196476	0	FGFR2	71,76	fibroblast_growth_factor_receptor_2	34,69	FGFR2	fibroblast growth factor receptor 2	2263	2263	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the human fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- gene and comparative analysis of the human FGFR gene family .
11711827	0	FGFR2	59,64	fibroblast_growth_factor_receptor_2	21,56	FGFR2	fibroblast growth factor receptor 2	2263	2263	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Sequence analysis of fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- in Japanese patients with craniosynostosis .
15206560	0	FGFR2	178,183	fibroblast_growth_factor_receptor_2	136,171	FGFR2	fibroblast growth factor receptor 2	2263	2263	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinically mild , atypical , and aged craniofacial_syndrome is diagnosed as Crouzon_syndrome by identification of a point mutation in the fibroblast_growth_factor_receptor_2 gene -LRB- FGFR2 -RRB- .
26600631	0	FGFR2	84,89	fibroblast_growth_factor_receptor_2	47,82	FGFR2	fibroblast growth factor receptor 2	2263	2263	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular analysis of exons 8 , 9 and 10 of the fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- gene in two families with index cases of Apert Syndrome .
9150725	0	FGFR2	76,81	fibroblast_growth_factor_receptor_2	39,74	FGFR2	fibroblast growth factor receptor 2	2263	2263	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Trp290Cys mutation in exon IIIa of the fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- gene is associated with Pfeiffer_syndrome .
23071632	0	FGFR2-IIIC	17,27	FGF-2	42,47	FGFR2-IIIC	FGF-2	2263	2247	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation .
27091807	0	FGFR3	60,65	Fibroblast_Growth_Factor_Receptor_3	23,58	FGFR3	Fibroblast Growth Factor Receptor 3	2261	2261	Gene	Gene	Mutations|appos|START_ENTITY Mutations|compound|END_ENTITY	Tumor Heterogeneity of Fibroblast_Growth_Factor_Receptor_3 -LRB- FGFR3 -RRB- Mutations in Invasive Bladder_Cancer : Implications for Peri-Operative anti-FGFR3 Treatment .
17441958	0	FGFR3	37,42	Fibroblast_growth_factor_receptor_3	0,35	FGFR3	Fibroblast growth factor receptor 3	2261	2261	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- mutation in a verrucous_epidermal_naevus associated with mild facial_dysmorphism .
16849642	0	FGFR3	44,49	MIP-1alpha	0,10	FGFR3	MIP-1alpha	2261	6348	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MIP-1alpha -LRB- CCL3 -RRB- is a downstream target of FGFR3 and RAS-MAPK signaling in multiple_myeloma .
25311528	0	FGFR3	27,32	PTPN1	36,41	FGFR3	PTPN1	2261	5770	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of FGFR3 by PTPN1 and PTPN2 .
17785202	0	FGFR3	0,5	RSK2	16,20	FGFR3	RSK2	2261	6197	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway .
17785202	0	FGFR3	0,5	RSK2	97,101	FGFR3	RSK2	2261	6197	Gene	Gene	activates|nsubj|START_ENTITY activates|xcomp|mediate mediate|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway .
21273290	0	FGFR3	0,5	SHOX	55,59	FGFR3	SHOX	2261	6473	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	FGFR3 is a target of the homeobox transcription factor SHOX in limb development .
18485666	0	FGFR3	19,24	Sprouty_2	0,9	FGFR3	Sprouty 2	2261	10253	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	Sprouty_2 disturbs FGFR3 degradation in thanatophoric_dysplasia_type_II : a severe form of human achondroplasia .
12960068	0	FGFR3	208,213	fibroblast_growth_factor_receptor-3	14,49	FGFR3	fibroblast growth factor receptor-3	84489(Tax:10116)	84489(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of fibroblast_growth_factor_receptor-3 -LRB- FGFR3 -RRB- , signal_transducer_and_activator_of_transcription-1 , and cyclin-dependent kinase inhibitor p21 during endochondral ossification : differential role of FGFR3 in skeletal development and fracture repair .
10914960	0	FGFR3	73,78	fibroblast_growth_factor_receptor_3	31,66	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A unique point mutation in the fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- causes non-syndromic_craniosynostosis .
11245416	0	FGFR3	41,46	fibroblast_growth_factor_receptor_3	4,39	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	The fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- mutation is a strong indicator of superficial bladder_cancer with low recurrence rate .
12354143	0	FGFR3	48,53	fibroblast_growth_factor_receptor_3	11,46	FGFR3	fibroblast growth factor receptor 3	281769(Tax:9913)	281769(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The bovine fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- gene is not the locus responsible for bovine chondrodysplastic_dwarfism in Japanese brown cattle .
19551630	0	FGFR3	69,74	fibroblast_growth_factor_receptor_3	32,67	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The G1138A mutation rate in the fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- gene is increased in cells carrying the t -LRB- 4 ; 14 -RRB- translocation .
20439987	0	FGFR3	67,72	fibroblast_growth_factor_receptor_3	30,65	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	NF449 is a novel inhibitor of fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- signaling active in chondrocytes and multiple myeloma cells .
21264819	0	FGFR3	55,60	fibroblast_growth_factor_receptor_3	13,48	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Incidence of fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- A248C , S249C , G372C , and T375C mutations in bladder_cancer .
25505835	0	FGFR3	100,105	fibroblast_growth_factor_receptor_3	63,98	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequency of the allelic variant c. 1150T _ > _ C in exon 10 of the fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- gene is not increased in patients with pathogenic mutations and related chondrodysplasia phenotypes .
8428519	0	FGFR3	46,51	fibroblast_growth_factor_receptor_3	4,39	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- is assigned to human chromosome 4 .
9042914	0	FGFR3	73,78	fibroblast_growth_factor_receptor_3	31,66	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A unique point mutation in the fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- defines a new craniosynostosis_syndrome .
9254852	0	FGFR3	48,53	fibroblast_growth_factor_receptor_3	6,41	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- : genomic sequence and primer set information for gene analysis .
9279764	0	FGFR3	66,71	fibroblast_growth_factor_receptor_3	29,64	FGFR3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Phenotypic expression of the fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- mutation P250R in a large craniosynostosis family .
24550147	0	FGFR4	0,5	Bim	27,30	FGFR4	Bim	2264	10018	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	FGFR4 signaling couples to Bim and not Bmf to discriminate subsets of alveolar_rhabdomyosarcoma cells .
26183471	0	FGFR4	9,14	Erk	109,112	FGFR4	Erk	2264	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	FGF-1 / -3 / FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon_cancer through Erk and MMP-7 .
22034009	0	FGFR4	42,47	Fibroblast_growth_factor_receptor_4	0,35	FGFR4	Fibroblast growth factor receptor 4	2264	2264	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fibroblast_growth_factor_receptor_4 gene -LRB- FGFR4 -RRB- 388Arg allele predicts prolonged survival and platinum sensitivity in advanced ovarian_cancer .
24026051	0	FGFRL1	33,39	FGFR1	63,68	FGFRL1	FGFR1	116701(Tax:10090)	14182(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1 .
21616146	0	FGFRL1	28,34	Spred1	63,69	FGFRL1	Spred1	53834	161742	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the receptor FGFRL1 with the negative regulator Spred1 .
8723101	0	FGFR_3	61,67	fibroblast_growth_factor_receptor_3	24,59	FGFR 3	fibroblast growth factor receptor 3	2261	2261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common mutations in the fibroblast_growth_factor_receptor_3 -LRB- FGFR_3 -RRB- gene account for achondroplasia , hypochondroplasia , and thanatophoric_dwarfism .
18302981	0	FGF_receptor	31,43	Cadherin-11	0,11	FGF receptor	Cadherin-11	2263	1009	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cadherin-11 interacts with the FGF_receptor and induces neurite outgrowth through associated downstream signalling .
8957000	0	FGF_receptor	24,36	Heartless	0,9	FGF receptor	Heartless	42160(Tax:7227)	42160(Tax:7227)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Heartless , a Drosophila FGF_receptor homolog , is essential for cell migration and establishment of several mesodermal lineages .
1656953	0	FGF_receptor	90,102	MYCN	9,13	FGF receptor	MYCN	2263	4613	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|compound|END_ENTITY	Enhanced MYCN oncogene expression in human neuroblastoma cells is associated with altered FGF_receptor expression and cellular growth response to basic FGF .
1325393	0	FGF_receptor	25,37	breathless	0,10	FGF receptor	breathless	39564(Tax:7227)	39564(Tax:7227)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	breathless , a Drosophila FGF_receptor homolog , is essential for migration of tracheal and specific midline glial cells .
8125257	0	FGF_receptor	52,64	breathless	27,37	FGF receptor	breathless	39564(Tax:7227)	39564(Tax:7227)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Elucidation of the role of breathless , a Drosophila FGF_receptor homolog , in tracheal cell migration .
12944911	0	FGF_receptor-2	14,28	E2F-1	64,69	FGF receptor-2	E2F-1	14183(Tax:10090)	13555(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of FGF_receptor-2 expression by transcription factor E2F-1 .
17682060	0	FGF_receptor_2	113,127	fibroblast_growth_factor_10	77,104	FGF receptor 2	fibroblast growth factor 10	2263	2255	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Lacrimo-auriculo-dento-digital_syndrome is caused by reduced activity of the fibroblast_growth_factor_10 -LRB- FGF10 -RRB- - FGF_receptor_2 signaling pathway .
17445871	0	FGG	22,25	fibrinogen_gamma	4,20	FGG	fibrinogen gamma	2266	2266	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	The fibrinogen_gamma -LRB- FGG -RRB- 10034C > T polymorphism is associated with venous_thrombosis .
15025951	0	FGG	61,64	fibrinogen_gamma_polypeptide	31,59	FGG	fibrinogen gamma polypeptide	2266	2266	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Cloning and identification of fibrinogen_gamma_polypeptide -LRB- FGG -RRB- gene differentially expressed in human hepatocellular_carcinoma -RSB- .
21469939	0	FGL2	31,35	prothrombinase	4,18	FGL2	prothrombinase	14190(Tax:10090)	14190(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis .
23664593	0	FGL2	8,12	tumor_necrosis_factor-a	24,47	FGL2	tumor necrosis factor-a	10875	7124	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Soluble FGL2 induced by tumor_necrosis_factor-a and interferon-y in CD4 + T cells through MAPK pathway in human renal allograft acute rejection .
14695314	0	FH	46,48	fumarate_hydratase	26,44	FH	fumarate hydratase	2271	2271	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Biallelic inactivation of fumarate_hydratase -LRB- FH -RRB- occurs in nonsyndromic uterine leiomyomas but is rare in other tumors .
26173633	0	FH	54,56	fumarate_hydratase	34,52	FH	fumarate hydratase	2271	2271	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel splice site mutation in the fumarate_hydratase -LRB- FH -RRB- gene is associated with multiple cutaneous leiomyomas in a Japanese patient .
318155	0	FH	43,45	fumarate_hydratase	23,41	FH	fumarate hydratase	2271	2271	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Gene dosage effect for fumarate_hydratase -LRB- FH ; E.C. 4.2.1.2 -RRB- in partial trisomy 1 .
15140207	0	FHF-2	75,80	fibroblast_growth_factor-13	46,73	FHF-2	fibroblast growth factor-13	14168(Tax:10090)	14168(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Bulge - and basal layer-specific expression of fibroblast_growth_factor-13 -LRB- FHF-2 -RRB- in mouse skin .
12890744	0	FHIT	41,45	BAGE	88,92	FHIT	BAGE	2272	574	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Analysis of the tumour suppressor genes , FHIT and WT-1 , _ and_the_tumour rejection genes , BAGE , GAGE-1 / 2 , HAGE , MAGE-1 , and MAGE-3 , in benign and malignant_neoplasms of the salivary glands .
16027075	0	FHIT	16,20	CDK4	35,39	FHIT	CDK4	2272	1019	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|dep|END_ENTITY	-LSB- Expressions of FHIT and cyclin_D1 / CDK4 in oral_cancer and oral precancerous_lesions -RSB- .
19502167	0	FHIT	41,45	DNA_methyltransferase_3b	13,37	FHIT	DNA methyltransferase 3b	2272	1789	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Influence of DNA_methyltransferase_3b on FHIT expression and DNA methylation of the FHIT promoter region in hepatoma SMMC-7721 cells .
9290949	0	FHIT	28,32	FRA3B	76,81	FHIT	FRA3B	2272	2272	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Precise localization of the FHIT gene to the common fragile site at 3p14 .2 -LRB- FRA3B -RRB- and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines .
20606729	0	FHIT	91,95	Fragile_Histidine_Triad	66,89	FHIT	Fragile Histidine Triad	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the promoter methylation and protein expression of Fragile_Histidine_Triad -LRB- FHIT -RRB- gene with the progression of differentiated_thyroid_carcinoma .
19452299	0	FHIT	25,29	Fragile_histidine_triad	0,23	FHIT	Fragile histidine triad	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fragile_histidine_triad -LRB- FHIT -RRB- gene and its association with p53 protein expression in the progression of gall_bladder_cancer .
12169206	0	FHIT	7,11	INK4	24,28	FHIT	INK4	2272	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	MYCL1 , FHIT , SPARC , p16 -LRB- INK4 -RRB- and TP53 genes associated to lung_cancer in idiopathic_pulmonary_fibrosis .
11932901	0	FHIT	102,106	INK4A	111,116	FHIT	INK4A	2272	1029	Gene	Gene	START_ENTITY|appos|p16 p16|appos|END_ENTITY	Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT , p16 -LRB- INK4A -RRB- , and p19 -LRB- ARF -RRB- genes in nasopharyngeal_carcinoma .
12169206	0	FHIT	7,11	SPARC	13,18	FHIT	SPARC	2272	6678	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	MYCL1 , FHIT , SPARC , p16 -LRB- INK4 -RRB- and TP53 genes associated to lung_cancer in idiopathic_pulmonary_fibrosis .
9689122	0	FHIT	60,64	TRC8	92,96	FHIT	TRC8	2272	11236	Gene	Gene	START_ENTITY|nmod|gene gene|appos|END_ENTITY	The hereditary_renal_cell_carcinoma 3 ; 8 translocation fuses FHIT to a patched-related gene , TRC8 .
22440786	0	FHIT	145,149	VHL	161,164	FHIT	VHL	2272	7428	Gene	Gene	START_ENTITY|nmod|status status|compound|END_ENTITY	Enduring response to everolimus as third-line therapy in a patient with advanced_renal_cell_carcinoma , including small-bowel metastases : loss of FHIT but normal VHL gene status .
10930803	0	FHIT	41,45	fragile_histidine_triad	16,39	FHIT	fragile histidine triad	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the fragile_histidine_triad -LRB- FHIT -RRB- gene in lobular breast_cancer .
12095833	0	FHIT	33,37	fragile_histidine_triad	8,31	FHIT	fragile histidine triad	2272	2272	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Loss of fragile_histidine_triad -LRB- FHIT -RRB- expression and microsatellite instability in periocular_sebaceous_gland_carcinoma in patients with Muir-Torre_syndrome .
16313263	0	FHIT	47,51	fragile_histidine_triad	22,45	FHIT	fragile histidine triad	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylation status of fragile_histidine_triad -LRB- FHIT -RRB- gene and its clinical impact on prognosis of patients with multiple_myeloma .
16343073	0	FHIT	78,82	fragile_histidine_triad	53,76	FHIT	fragile histidine triad	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter methylation and loss of coding exons of the fragile_histidine_triad -LRB- FHIT -RRB- gene in intrahepatic_cholangiocarcinomas .
17609851	0	FHIT	48,52	fragile_histidine_triad	23,46	FHIT	fragile histidine triad	2272	2272	Gene	Gene	Lack|appos|START_ENTITY Lack|nmod|association association|nmod|END_ENTITY	Lack of association of fragile_histidine_triad -LRB- FHIT -RRB- polymorphisms with lung_cancer in the Korean population .
18367246	0	FHIT	47,51	fragile_histidine_triad	22,45	FHIT	fragile histidine triad	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylation status of fragile_histidine_triad -LRB- FHIT -RRB- gene and its clinical impact on prognosis of patients with myelodysplastic_syndrome .
20083852	0	FHIT	47,51	fragile_histidine_triad	22,45	FHIT	fragile histidine triad	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Overexpression of the fragile_histidine_triad -LRB- FHIT -RRB- gene in inflammatory_bowel_disease .
10920977	0	FHIT	46,50	fragile_histidine_triad_gene	16,44	FHIT	fragile histidine triad gene	2272	2272	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	-LSB- Association of fragile_histidine_triad_gene -LRB- FHIT -RRB- with susceptibility to esophageal_cancer .
11085938	0	FHIT	15,19	hUBC9	121,126	FHIT	hUBC9	2272	7329	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of FHIT -LRB- fragile histidine triad -RRB- , a candidate tumour suppressor gene , with the ubiquitin-conjugating enzyme hUBC9 .
24587882	0	FHIT	57,61	p16	68,71	FHIT	p16	2272	1029	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Loss of Heterozygosities in Five Tumor Suppressor Genes -LRB- FHIT Gene , p16 , pRb , E-Cadherin and p53 -RRB- in Thyroid_Tumors .
12402151	0	FHL-1	79,84	factor_H	43,51	FHL-1	factor H	2273	3075	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Secretion of soluble complement inhibitors factor_H and factor_H-like protein -LRB- FHL-1 -RRB- by ovarian_tumour cells .
16619241	0	FHL2	0,4	ADAM-17	25,32	FHL2	ADAM-17	14200(Tax:10090)	11491(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity .
14550570	0	FHL2	21,25	BRCA1	0,5	FHL2	BRCA1	2274	672	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRCA1 interacts with FHL2 and enhances FHL2 transactivation function .
22829078	0	FHL2	0,4	CALM	20,24	FHL2	CALM	2274	8301	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FHL2 interacts with CALM and is highly expressed in acute_erythroid_leukemia .
16652157	0	FHL2	21,25	E4F1	53,57	FHL2	E4F1	2274	1877	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The LIM-only protein FHL2 is a negative regulator of E4F1 .
11135358	0	FHL2	41,45	FHL3	31,35	FHL2	FHL3	2274	2275	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins -LRB- GFP -RRB- two-fusion fluorescence resonance energy transfer -LRB- FRET -RRB- .
18224250	0	FHL2	19,23	IL-1beta	0,8	FHL2	IL-1beta	2274	3553	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IL-1beta regulates FHL2 and other cytoskeleton-related genes in human chondrocytes .
26320172	0	FHL2	113,117	KLF8	0,4	FHL2	KLF8	2274	11279	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	KLF8 promotes tumorigenesis , invasion and metastasis of colorectal_cancer cells by transcriptional activation of FHL2 .
12151099	0	FHL2	25,29	WT1	40,43	FHL2	WT1	2274	7490	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nummod|END_ENTITY	The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation .
12370240	0	FHL2	21,25	beta-catenin	41,53	FHL2	beta-catenin	14200(Tax:10090)	12387(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts .
12466281	0	FHL2	34,38	beta-catenin	59,71	FHL2	beta-catenin	2274	1499	Gene	Gene	START_ENTITY|nmod|coactivator coactivator|nmod|END_ENTITY	Identification of the LIM protein FHL2 as a coactivator of beta-catenin .
18378678	0	FHL2	21,25	cyclin_D1	36,45	FHL2	cyclin D1	14200(Tax:10090)	12443(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The LIM-only protein FHL2 regulates cyclin_D1 expression and cell proliferation .
19018287	0	FHL2	21,25	cyclin_D1	70,79	FHL2	cyclin D1	14200(Tax:10090)	12443(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|pathways pathways|compound|END_ENTITY	The LIM-only protein FHL2 mediates ras-induced transformation through cyclin_D1 and p53 pathways .
20607723	0	FHL2	41,45	four_and_half_lim_2	20,39	FHL2	four and half lim 2	2274	2274	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Sp1 upregulates the four_and_half_lim_2 -LRB- FHL2 -RRB- expression in gastrointestinal_cancers through transcription regulation .
10649446	0	FHL2	31,35	hCDC47	104,110	FHL2	hCDC47	2274	4176	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Protein-protein interaction of FHL2 , a LIM domain protein preferentially expressed in human heart , with hCDC47 .
22633286	0	FHL2	21,25	interleukin-6	36,49	FHL2	interleukin-6	2274	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-kB pathway in muscle cells .
12694872	0	FHL2	63,67	phosphatase_2A	121,135	FHL2	phosphatase 2A	2274	5524	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the coactivator four-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase_2A .
11135358	0	FHL3	31,35	FHL2	41,45	FHL3	FHL2	2275	2274	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Protein-protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins -LRB- GFP -RRB- two-fusion fluorescence resonance energy transfer -LRB- FRET -RRB- .
17389685	0	FHL3	0,4	MyoD	11,15	FHL3	MyoD	14201(Tax:10090)	17927(Tax:10090)	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	FHL3 binds MyoD and negatively regulates myotube formation .
24459464	0	FHL4	54,58	Syntaxin-11	69,80	FHL4	Syntaxin-11	8676	8676	Gene	Gene	Binding|compound|START_ENTITY Binding|compound|END_ENTITY	An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2 .
16169515	0	FHOD1	59,64	Src	0,3	FHOD1	Src	29109	6714	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Src regulates the activity of the mammalian formin protein FHOD1 .
26069075	0	FIAF	34,38	Angptl4	25,32	FIAF	Angptl4	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
26069075	0	FIAF	34,38	Interleukin-1b	0,14	FIAF	Interleukin-1b	57875(Tax:10090)	16176(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY END_ENTITY|dobj|Expression	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
24293368	0	FIBCD1	108,114	fibrinogen_C_domain_containing_1	74,106	FIBCD1	fibrinogen C domain containing 1	84929	84929	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Crystal structure of the tetrameric fibrinogen-like recognition domain of fibrinogen_C_domain_containing_1 -LRB- FIBCD1 -RRB- protein .
21732131	0	FIH-1	12,17	HIF-1a	79,85	FIH-1	HIF-1a	55662	3091	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Subcellular FIH-1 expression patterns in invasive breast_cancer in relation to HIF-1a expression .
22532441	0	FIH-1	20,25	MicroRNA-31	0,11	FIH-1	MicroRNA-31	55662	407035	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism .
23548624	0	FIH-1	0,5	c-kit	6,11	FIH-1	c-kit	319594(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|appos|signaling signaling|nsubj|END_ENTITY	FIH-1 / c-kit signaling : a novel contributor to corneal epithelial glycogen metabolism .
24465898	0	FIH-1	35,40	factor_inhibiting_HIF	12,33	FIH-1	factor inhibiting HIF	55662	55662	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of factor_inhibiting_HIF -LRB- FIH-1 -RRB- in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme .
18204739	0	FIP	80,83	Fas_ligand	48,58	FIP	Fas ligand	7392	356	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Cloning and purification of functionally active Fas_ligand interfering protein -LRB- FIP -RRB- expressed in Escherichia_coli .
11137014	0	FIP-2	0,5	Huntingtin	36,46	FIP-2	Huntingtin	10133	3064	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	FIP-2 , a coiled-coil protein , links Huntingtin to Rab8 and modulates cellular morphogenesis .
11137014	0	FIP-2	0,5	Rab8	50,54	FIP-2	Rab8	10133	4218	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	FIP-2 , a coiled-coil protein , links Huntingtin to Rab8 and modulates cellular morphogenesis .
18539901	0	FIP1L1/PDGFRalpha	0,17	SCF	34,37	FIP1L1/PDGFRalpha	SCF	66899;18595	17311(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	FIP1L1/PDGFRalpha synergizes with SCF to induce systemic_mastocytosis in a murine model of chronic_eosinophilic_leukemia / hypereosinophilic_syndrome .
11777338	0	FIP2	37,41	Ag-9C5	53,59	FIP2	Ag-9C5	374079(Tax:9031)	374079(Tax:9031)	Gene	Gene	localization|nmod|START_ENTITY localization|amod|END_ENTITY	Differential localization of chicken FIP2 homologue , Ag-9C5 , in secretory epithelial cells .
12221124	0	FIP200	65,71	focal_adhesion_kinase	14,35	FIP200	focal adhesion kinase	9821	5747	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of focal_adhesion_kinase by a novel protein inhibitor FIP200 .
18685082	0	FIP3	66,70	ASAP1	30,35	FIP3	ASAP1	8517	50807	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome .
18059478	0	FIR	16,19	FUSE	25,29	FIR	FUSE	22827	2522	Gene	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition .
26492245	0	FIT1	37,41	MyoD	0,4	FIT1	MyoD	161247	4654	Gene	Gene	Gene|compound|START_ENTITY Activator|nmod|Gene Activator|nsubj|END_ENTITY	MyoD Is a Novel Activator of Porcine FIT1 Gene by Interacting with the Canonical E-Box Element during Myogenesis .
12182072	0	FIX	26,29	hFIX	30,34	FIX	hFIX	2158	2158	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	-LSB- High expression of human FIX -LRB- hFIX -RRB- in transgenic_mice directed by goat beta-casein gene promoter -RSB- .
14602788	0	FIZZ3	16,21	resistin	6,14	FIZZ3	resistin	56729	56729	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Serum resistin -LRB- FIZZ3 -RRB- protein is increased in obese humans .
7511990	0	FK-506_binding_protein	70,92	FKBP-12	104,111	FK-506 binding protein	FKBP-12	100328942(Tax:9986)	100328942(Tax:9986)	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	The calcium release channel of sarcoplasmic reticulum is modulated by FK-506_binding_protein : effect of FKBP-12 on single channel activity of the skeletal_muscle_ryanodine_receptor .
16176796	0	FK-506_binding_protein_38	30,55	Bcl-2	120,125	FK-506 binding protein 38	Bcl-2	23770	596	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of FK-506_binding_protein_38 and its potential regulatory role on the anti-apoptotic protein Bcl-2 .
9545268	0	FK506-binding_protein_12	11,35	epidermal_growth_factor_receptor	72,104	FK506-binding protein 12	epidermal growth factor receptor	2280	1956	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of FK506-binding_protein_12 and FK506 on autophosphorylation of epidermal_growth_factor_receptor .
12606707	0	FK506-binding_protein_13	15,39	BIG1	106,110	FK506-binding protein 13	BIG1	2286	10565	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Interaction of FK506-binding_protein_13 with brefeldin_A-inhibited_guanine_nucleotide-exchange protein 1 -LRB- BIG1 -RRB- : effects of FK506 .
22825419	0	FK506-binding_protein_51	0,24	FKBP5	26,31	FK506-binding protein 51	FKBP5	2289	2289	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	FK506-binding_protein_51 -LRB- FKBP5 -RRB- gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic_thrombocytopenic_purpura .
23861224	0	FK506-binding_protein_51	28,52	FKBP5	54,59	FK506-binding protein 51	FKBP5	2289	2289	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Role of allelic variants of FK506-binding_protein_51 -LRB- FKBP5 -RRB- gene in the development of anxiety_disorders .
25053194	0	FK506-binding_protein_52	14,38	FKBP52	40,46	FK506-binding protein 52	FKBP52	2288	2288	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of FK506-binding_protein_52 -LRB- FKBP52 -RRB- in chorionic villi with early recurrent spontaneous_abortion .
23263277	0	FK506_binding_protein_5	8,31	FKBP5	33,38	FK506 binding protein 5	FKBP5	14229(Tax:10090)	14229(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of FK506_binding_protein_5 -LRB- FKBP5 -RRB- in osteoclast differentiation .
26535939	0	FK506_binding_protein_5	107,130	FKBP5	137,142	FK506 binding protein 5	FKBP5	2289	2289	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Developmental pathways from child maltreatment to adolescent marijuana_dependence : Examining moderation by FK506_binding_protein_5 gene -LRB- FKBP5 -RRB- .
26535949	0	FK506_binding_protein_5	42,65	FKBP5	72,77	FK506 binding protein 5	FKBP5	2289	2289	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Childhood maltreatment and methylation of FK506_binding_protein_5 gene -LRB- FKBP5 -RRB- .
7511990	0	FKBP-12	104,111	FK-506_binding_protein	70,92	FKBP-12	FK-506 binding protein	100328942(Tax:9986)	100328942(Tax:9986)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	The calcium release channel of sarcoplasmic reticulum is modulated by FK-506_binding_protein : effect of FKBP-12 on single channel activity of the skeletal_muscle_ryanodine_receptor .
16176935	0	FKBP12	30,36	Ryanodine_receptor	0,18	FKBP12	Ryanodine receptor	2280	6261	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Ryanodine_receptor binding to FKBP12 is modulated by channel activation state .
24499793	0	FKBP12	0,6	amyloid_precursor_protein	52,77	FKBP12	amyloid precursor protein	2282	351	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	FKBP12 regulates the localization and processing of amyloid_precursor_protein in human cell lines .
11279144	0	FKBP12	0,6	ryanodine_receptor	25,43	FKBP12	ryanodine receptor	2280	6261	Gene	Gene	binding|compound|START_ENTITY modulates|nsubj|binding modulates|dobj|channel channel|compound|END_ENTITY	FKBP12 binding modulates ryanodine_receptor channel gating .
11751303	0	FKBP12	0,6	ryanodine_receptor	49,67	FKBP12	ryanodine receptor	2280	6261	Gene	Gene	modulation|nummod|START_ENTITY END_ENTITY|nsubj|modulation	FKBP12 modulation of the binding of the skeletal ryanodine_receptor onto the II-III loop of the dihydropyridine_receptor .
7669046	0	FKBP12	141,147	ryanodine_receptor	29,47	FKBP12	ryanodine receptor	2280	6261	Gene	Gene	association|nmod|START_ENTITY skeletal|advcl|association purification|parataxis|skeletal purification|nmod|END_ENTITY	Affinity purification of the ryanodine_receptor / calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12 .
22244380	0	FKBP22	78,84	PPIase	59,65	FKBP22	PPIase	55033	2289	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Role of polar and nonpolar residues at the active site for PPIase activity of FKBP22 from Shewanella sp .
14960307	0	FKBP23	10,16	BiP	26,29	FKBP23	BiP	14231(Tax:10090)	14828(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2 + concentration .
17223077	0	FKBP23	15,21	BiP	39,42	FKBP23	BiP	14231(Tax:10090)	14828(Tax:10090)	Gene	Gene	The|nmod|START_ENTITY modulates|nsubj|The modulates|dobj|activity activity|nmod:poss|END_ENTITY	The binding of FKBP23 to BiP modulates BiP 's ATPase activity with its PPIase activity .
17425118	0	FKBP23	11,17	BiP	21,24	FKBP23	BiP	14231(Tax:10090)	14828(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of FKBP23 to BiP in ER shown by gel filtration chromatography .
21527244	0	FKBP23	6,12	BiP	54,57	FKBP23	BiP	14231(Tax:10090)	14828(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|functions functions|nmod|END_ENTITY	Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117 cis/trans isomerization .
26239116	0	FKBP25	0,6	TRPC6	66,71	FKBP25	TRPC6	2287	7225	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6 .
12510191	0	FKBP38	31,37	Bcl-2	46,51	FKBP38	Bcl-2	23770	596	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis .
14968553	0	FKBP38	14,20	Bcl-2	68,73	FKBP38	Bcl-2	23770	596	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	-LSB- Immunophilin FKBP38 , an inherent inhibitor of calcineurin , targets Bcl-2 to mitochondria and inhibits apoptosis -RSB- .
15733859	0	FKBP38	115,121	Bcl-2	21,26	FKBP38	Bcl-2	23770	596	Gene	Gene	FK-506_binding_protein_38|appos|START_ENTITY required|nmod|FK-506_binding_protein_38 required|nsubjpass|loop loop|nmod|END_ENTITY	The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506_binding_protein_38 -LRB- FKBP38 -RRB- .
15905180	0	FKBP38	32,38	Bcl-2	84,89	FKBP38	Bcl-2	14232(Tax:10090)	12043(Tax:10090)	Gene	Gene	presenilins|nmod|START_ENTITY Interaction|nmod|presenilins promotes|nsubj|Interaction promotes|advcl|reducing reducing|dobj|END_ENTITY	Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2 .
20048149	0	FKBP38	60,66	Bcl-2	72,77	FKBP38	Bcl-2	23770	596	Gene	Gene	interaction|nmod|START_ENTITY regulating|dobj|interaction regulating|nmod|END_ENTITY	Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL .
20139069	0	FKBP38	0,6	Bcl-2	16,21	FKBP38	Bcl-2	23770	596	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	FKBP38 protects Bcl-2 from caspase-dependent degradation .
20140889	0	FKBP38	31,37	Bcl-2	65,70	FKBP38	Bcl-2	23770	596	Gene	Gene	domain|compound|START_ENTITY loop|nmod|domain modulates|nsubj|loop modulates|xcomp|binding binding|nsubj|END_ENTITY	A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding .
22523079	0	FKBP38	4,10	Bcl-2	37,42	FKBP38	Bcl-2	23770	596	Gene	Gene	domain|compound|START_ENTITY binds|nsubj|domain binds|nmod|END_ENTITY	The FKBP38 catalytic domain binds to Bcl-2 via a charge-sensitive loop .
24295050	0	FKBP38	46,52	Bcl-2	58,63	FKBP38	Bcl-2	23770	596	Gene	Gene	interaction|nmod|START_ENTITY inhibit|dobj|interaction inhibit|nmod|END_ENTITY	Ca2 + / S100 proteins inhibit the interaction of FKBP38 with Bcl-2 and Hsp90 .
22279148	0	FKBP4	0,5	HOXA10	22,28	FKBP4	HOXA10	2288	3206	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	FKBP4 is regulated by HOXA10 during decidualization and in endometriosis .
22825419	0	FKBP5	26,31	FK506-binding_protein_51	0,24	FKBP5	FK506-binding protein 51	2289	2289	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	FK506-binding_protein_51 -LRB- FKBP5 -RRB- gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic_thrombocytopenic_purpura .
23861224	0	FKBP5	54,59	FK506-binding_protein_51	28,52	FKBP5	FK506-binding protein 51	2289	2289	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Role of allelic variants of FK506-binding_protein_51 -LRB- FKBP5 -RRB- gene in the development of anxiety_disorders .
23263277	0	FKBP5	33,38	FK506_binding_protein_5	8,31	FKBP5	FK506 binding protein 5	14229(Tax:10090)	14229(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of FK506_binding_protein_5 -LRB- FKBP5 -RRB- in osteoclast differentiation .
26535939	0	FKBP5	137,142	FK506_binding_protein_5	107,130	FKBP5	FK506 binding protein 5	2289	2289	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Developmental pathways from child maltreatment to adolescent marijuana_dependence : Examining moderation by FK506_binding_protein_5 gene -LRB- FKBP5 -RRB- .
26535949	0	FKBP5	72,77	FK506_binding_protein_5	42,65	FKBP5	FK506 binding protein 5	2289	2289	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Childhood maltreatment and methylation of FK506_binding_protein_5 gene -LRB- FKBP5 -RRB- .
25912394	0	FKBP5	95,100	Glucocorticoid_Receptor	23,46	FKBP5	Glucocorticoid Receptor	2289	2908	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Altered mRNA Levels of Glucocorticoid_Receptor , Mineralocorticoid Receptor , and Co-Chaperones -LRB- FKBP5 and PTGES3 -RRB- in the Middle Frontal Gyrus of Autism Spectrum Disorder Subjects .
25849320	0	FKBP51	0,6	GSK3b	16,21	FKBP51	GSK3b	14229(Tax:10090)	2932	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	FKBP51 inhibits GSK3b and augments the effects of distinct psychotropic medications .
26207810	0	FKBP52	4,10	Androgen_Receptor	68,85	FKBP52	Androgen Receptor	2288	367	Gene	Gene	Acts|compound|START_ENTITY Acts|nmod|Signaling Signaling|compound|END_ENTITY	The FKBP52 Cochaperone Acts in Synergy with b-Catenin to Potentiate Androgen_Receptor Signaling .
26207810	0	FKBP52	4,10	Androgen_Receptor	68,85	FKBP52	Androgen Receptor	2288	367	Gene	Gene	Acts|compound|START_ENTITY Acts|nmod|Signaling Signaling|compound|END_ENTITY	The FKBP52 Cochaperone Acts in Synergy with b-Catenin to Potentiate Androgen_Receptor Signaling .
8621687	0	FKBP52	79,85	CyP-40	100,106	FKBP52	CyP-40	2288	5481	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Cyclophilin_40 -LRB- CyP-40 -RRB- , mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding .
25053194	0	FKBP52	40,46	FK506-binding_protein_52	14,38	FKBP52	FK506-binding protein 52	2288	2288	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of FK506-binding_protein_52 -LRB- FKBP52 -RRB- in chorionic villi with early recurrent spontaneous_abortion .
10714679	0	FKBP52	67,73	IRF-4	32,37	FKBP52	IRF-4	2288	3662	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|compound|END_ENTITY	Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52 .
16352746	0	FKBP52	17,23	TRPV5	77,82	FKBP52	TRPV5	2288	56302	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	The immunophilin FKBP52 inhibits the activity of the epithelial Ca2 + channel TRPV5 .
21730179	0	FKBP52	97,103	androgen_receptor	28,45	FKBP52	androgen receptor	2288	367	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Targeting the regulation of androgen_receptor signaling by the heat_shock protein 90 cochaperone FKBP52 in prostate_cancer cells .
11278753	0	FKBP52	84,90	peptidylprolyl_isomerase	18,42	FKBP52	peptidylprolyl isomerase	2288	2289	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Evidence that the peptidylprolyl_isomerase domain of the hsp90-binding_immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid_receptor movement to the nucleus .
19876748	0	FKBP65	33,39	ROF2	27,31	FKBP65	ROF2	834913(Tax:3702)	834913(Tax:3702)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Arabidopsis ROF2 -LRB- FKBP65 -RRB- in thermotolerance .
23912458	0	FKBPL	48,53	RBCK1	18,23	FKBPL	RBCK1	63943	10616	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Identification of RBCK1 as a novel regulator of FKBPL : implications for tumor growth and response to tamoxifen .
9169153	0	FKHL_14	42,49	mesenchyme_fork_head-1	51,73	FKHL 14	mesenchyme fork head-1	2303	2303	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Isolation of the mouse -LRB- MFH-1 -RRB- and human -LRB- FKHL_14 -RRB- mesenchyme_fork_head-1 genes reveals conservation of their gene and protein structures .
10602488	0	FKHR	48,52	Akt	123,126	FKHR	Akt	2308	207	Gene	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|dobj|END_ENTITY	Regulation of the forkhead transcription factor FKHR , but not the PAX3-FKHR fusion protein , by the serine/threonine kinase Akt .
12456685	0	FKHR	55,59	Akt	0,3	FKHR	Akt	2308	207	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Akt modulates STAT3-mediated gene expression through a FKHR -LRB- FOXO1a -RRB- - dependent mechanism .
12691738	0	FKHR	86,90	Akt	76,79	FKHR	Akt	2308	207	Gene	Gene	GSK-3beta|appos|START_ENTITY GSK-3beta|compound|END_ENTITY	Ceramide-induced neuronal_apoptosis is associated with dephosphorylation of Akt , BAD , FKHR , GSK-3beta , and induction of the mitochondrial-dependent intrinsic caspase pathway .
11311120	0	FKHR	58,62	DYRK1A	11,17	FKHR	DYRK1A	2308	1859	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro , a novel in vivo phosphorylation site .
16020479	0	FKHR	45,49	FOXO1	38,43	FKHR	FOXO1	84482(Tax:10116)	84482(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the proapoptotic factor FOXO1 -LRB- FKHR -RRB- in cardiomyocytes by growth factors and alpha1-adrenergic agonists .
18303411	0	FKHR	20,24	FOXO1	13,18	FKHR	FOXO1	2308	2308	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of FOXO1 -LRB- FKHR -RRB- gene break-apart by fluorescence in situ hybridization in formalin-fixed , paraffin-embedded alveolar_rhabdomyosarcomas and its clinicopathologic correlation .
19772960	0	FKHR	15,19	FOXO1	21,26	FKHR	FOXO1	2308	2308	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of FKHR -LRB- FOXO1 -RRB- transcription factor in human uterus_leiomyoma growth .
12130586	0	FKHR	48,52	FOXO1a	54,60	FKHR	FOXO1a	2308	2308	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the forkhead transcription factor FKHR -LRB- FOXO1a -RRB- by glucose starvation and AICAR , an activator of AMP-activated protein kinase .
13679577	0	FKHR	35,39	Foxo1	41,46	FKHR	Foxo1	2308	2308	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Insulin-induced phosphorylation of FKHR -LRB- Foxo1 -RRB- targets to proteasomal degradation .
11786925	0	FKHR	86,90	alkaline_phosphatase	14,34	FKHR	alkaline phosphatase	2308	250	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of alkaline_phosphatase promoter activity by forkhead transcription factor FKHR .
11030146	0	FKHR	75,79	epidermal_growth_factor	86,109	FKHR	epidermal growth factor	2308	1950	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal_growth_factor treatment in human breast_cancer cells .
11467835	0	FKHR	151,155	glucose-6-phosphatase	38,59	FKHR	glucose-6-phosphatase	84482(Tax:10116)	25634(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate_carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells .
12507516	0	FKHR	27,31	glucose-6-phosphatase	51,72	FKHR	glucose-6-phosphatase	84482(Tax:10116)	25634(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	DYRK1 is a co-activator of FKHR -LRB- FOXO1a -RRB- - dependent glucose-6-phosphatase gene expression .
12586369	0	FKHR	32,36	lipoprotein_lipase	50,68	FKHR	lipoprotein lipase	56458(Tax:10090)	16956(Tax:10090)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	A forkhead transcription factor FKHR up-regulates lipoprotein_lipase expression in skeletal muscle .
15716005	0	FKLF-2	30,36	KLF13	38,43	FKLF-2	KLF13	51621	51621	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of FKLF-2 -LRB- KLF13 -RRB- gene in erythroid cells .
24294368	0	FKN	106,109	MiR-195	0,7	FKN	MiR-195	6376	406971	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-195 inhibits proliferation and growth and induces apoptosis of endometrial stromal cells by targeting FKN .
25025775	0	FLAP	35,39	5-Lipoxygenase	0,14	FLAP	5-Lipoxygenase	11690(Tax:10090)	11689(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	5-Lipoxygenase activating protein -LRB- FLAP -RRB- dependent leukotriene biosynthesis inhibition -LRB- MK591 -RRB- attenuates Lipid A endotoxin-induced inflammation .
9445303	0	FLAP	54,58	5-Lipoxygenase	0,14	FLAP	5-Lipoxygenase	241	240	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	5-Lipoxygenase and 5-lipoxygenase activating protein -LRB- FLAP -RRB- immunoreactivity in lungs from patients with primary_pulmonary_hypertension .
26327594	0	FLAP	88,92	5-lipoxygenase	45,59	FLAP	5-lipoxygenase	241	240	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|interaction interaction|nmod|END_ENTITY	Characterization of the interaction of human 5-lipoxygenase with its activating protein FLAP .
7741044	0	FLAP	45,49	5-lipoxygenase	115,129	FLAP	5-lipoxygenase	241	240	Gene	Gene	BAY_X_1005|appos|START_ENTITY action|nmod|BAY_X_1005 Mode|nmod|action Mode|dep|implications implications|nmod|regulation regulation|nmod|END_ENTITY	Mode of action of the leukotriene synthesis -LRB- FLAP -RRB- inhibitor BAY_X_1005 : implications for biological regulation of 5-lipoxygenase .
16278051	0	FLAP	27,31	ALOX5AP	33,40	FLAP	ALOX5AP	11690(Tax:10090)	11690(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	5-Lipoxygenase -LRB- ALOX5 -RRB- and FLAP -LRB- ALOX5AP -RRB- gene polymorphisms as factors in vascular pathology and Alzheimer 's _ disease .
17245429	0	FLASH	0,5	CD95	16,20	FLASH	CD95	9994	355	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies .
15592525	0	FLASH	8,13	NF-kappaB	107,116	FLASH	NF-kappaB	9994	4790	Gene	Gene	Role|nmod|START_ENTITY Role|dep|function function|nmod|mutant mutant|nmod|END_ENTITY	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
15592525	0	FLASH	8,13	NF-kappaB	50,59	FLASH	NF-kappaB	9994	4790	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
15592525	0	FLASH	91,96	NF-kappaB	107,116	FLASH	NF-kappaB	9994	4790	Gene	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
15592525	0	FLASH	91,96	NF-kappaB	50,59	FLASH	NF-kappaB	9994	4790	Gene	Gene	mutant|compound|START_ENTITY function|nmod|mutant Role|dep|function Role|nmod|FLASH FLASH|nmod|activation activation|nmod|END_ENTITY	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
16236152	0	FLC	41,44	FLOWERING_LOCUS_C	22,39	FLC	FLOWERING LOCUS C	830878(Tax:3702)	830878(Tax:3702)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The downregulation of FLOWERING_LOCUS_C -LRB- FLC -RRB- expression in plants with low levels of DNA methylation and by vernalization occurs by distinct mechanisms .
23273925	0	FLC	87,90	HAM1	42,46	FLC	HAM1	830878(Tax:3702)	836582(Tax:3702)	Gene	Gene	modification|nmod|START_ENTITY END_ENTITY|nmod|modification	Requirement of histone acetyltransferases HAM1 and HAM2 for epigenetic modification of FLC in regulating flowering in Arabidopsis .
12837955	0	FLC	43,46	PIE1	0,4	FLC	PIE1	830878(Tax:3702)	820463(Tax:3702)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	PIE1 , an ISWI family gene , is required for FLC activation and floral repression in Arabidopsis .
25126726	0	FLCN	0,4	GABARAP	50,57	FLCN	GABARAP	201163	11337	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FLCN , a novel autophagy component , interacts with GABARAP and is regulated by ULK1 phosphorylation .
18573707	0	FLCN	90,94	folliculin	78,88	FLCN	folliculin	201163	201163	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Birt-Hogg-Dub ___ -LRB- BHD -RRB- _ syndrome : report of two novel germline mutations in the folliculin -LRB- FLCN -RRB- gene .
19802896	0	FLCN	70,74	folliculin	58,68	FLCN	folliculin	201163	201163	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new locus-specific database -LRB- LSDB -RRB- for mutations in the folliculin -LRB- FLCN -RRB- gene .
16148010	0	FLI-1	0,5	PIASxalpha	34,44	FLI-1	PIASxalpha	2313	9063	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FLI-1 functionally interacts with PIASxalpha , a member of the PIAS E3 SUMO ligase family .
26538397	0	FLI1	0,4	CXCR3	19,24	FLI1	CXCR3	14247(Tax:10090)	12766(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain .
25870111	0	FLI1	57,61	SMAD1	0,5	FLI1	SMAD1	2313	4086	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	SMAD1 and SMAD5 expression is co-ordinately regulated by FLI1 and GATA2 during endothelial development .
10216102	0	FLICE	34,39	CD95	83,87	FLICE	CD95	841	355	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|interaction interaction|compound|END_ENTITY	Anticancer drugs induce caspase-8 / FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction .
19324905	0	FLICE	86,91	NF-kappaB	123,132	FLICE	NF-kappaB	841	4790	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Induction of CCL20 production by Kaposi_sarcoma-associated herpesvirus : role of viral FLICE inhibitory protein K13-induced NF-kappaB activation .
14636156	0	FLICE-inhibitory_protein	27,51	FLIP	53,57	FLICE-inhibitory protein	FLIP	8837	8837	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of cellular FLICE-inhibitory_protein -LRB- FLIP -RRB- in gastric_adenocarcinoma .
22095280	0	FLICE-inhibitory_protein	63,87	TNF	112,115	FLICE-inhibitory protein	TNF	12633(Tax:10090)	21926(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	In mouse embryonic fibroblasts , neither caspase-8 nor cellular FLICE-inhibitory_protein -LRB- FLIP -RRB- is necessary for TNF to activate NF-kB , but caspase-8 is required for TNF to cause cell death , and induction of FLIP by NF-kB is required to prevent it .
14662022	0	FLIP	16,20	Akt	27,30	FLIP	Akt	8837	207	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of FLIP -LRB- S -RRB- by Akt , a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric_cancers .
15985761	0	FLIP	139,143	Akt	100,103	FLIP	Akt	8837	207	Gene	Gene	form|nmod|START_ENTITY regulated|nmod|form regulated|nmod|END_ENTITY	TRAIL-induced apoptosis in human vascular endothelium is regulated by phosphatidylinositol_3-kinase / Akt through the short form of cellular FLIP and Bcl-2 .
12594270	0	FLIP	91,95	CD8	26,29	FLIP	CD8	8837	925	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression Inhibition|dep|regulation Inhibition|nmod|death death|compound|END_ENTITY	Inhibition of TCR-induced CD8 T cell death by IL-12 : regulation of Fas_ligand and cellular FLIP expression and caspase activation by IL-12 .
14636156	0	FLIP	53,57	FLICE-inhibitory_protein	27,51	FLIP	FLICE-inhibitory protein	8837	8837	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of cellular FLICE-inhibitory_protein -LRB- FLIP -RRB- in gastric_adenocarcinoma .
18391984	0	FLIP	53,57	FOXO3a	0,6	FLIP	FOXO3a	8837	2309	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells .
11765224	0	FLIP	111,115	Fas-associated_death_domain-like_interleukin-1beta-converting_enzyme	14,82	FLIP	Fas-associated death domain-like interleukin-1beta-converting enzyme	8837	841	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of Fas-associated_death_domain-like_interleukin-1beta-converting_enzyme -LRB- FLICE -RRB- inhibitory protein -LRB- FLIP -RRB- in human articular chondrocytes : possible contribution to the resistance to Fas-mediated death of in vitro cultured human articular chondrocytes .
12594270	0	FLIP	91,95	Fas_ligand	67,77	FLIP	Fas ligand	8837	356	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of TCR-induced CD8 T cell death by IL-12 : regulation of Fas_ligand and cellular FLIP expression and caspase activation by IL-12 .
21307400	0	FLIP	0,4	HO-1	19,23	FLIP	HO-1	8837	3162	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	FLIP regulation of HO-1 and TNF signalling in human acute_myeloid_leukemia provides a unique secondary anti-apoptotic mechanism .
12393527	0	FLIP	45,49	Stem_cell_factor	0,16	FLIP	Stem cell factor	8837	4254	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Stem_cell_factor increases the expression of FLIP that inhibits IFNgamma - induced apoptosis in human erythroid progenitor cells .
15367674	0	FLIP	21,25	c-myc	40,45	FLIP	c-myc	8837	4609	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity .
21235526	0	FLIP	0,4	caspase_8	16,25	FLIP	caspase 8	12633(Tax:10090)	12370(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	FLIP -LRB- L -RRB- induces caspase_8 activity in the absence of interdomain caspase_8 cleavage and alters substrate specificity .
24593859	0	FLK-1	65,70	c-kit	52,57	FLK-1	c-kit	3791	3815	Gene	Gene	Cells|dep|START_ENTITY Cells|dep|END_ENTITY	Embryonic Stem Cells and Released Factors Stimulate c-kit -LRB- + ve -RRB- / FLK-1 -LRB- + ve -RRB- Progenitor Cells and Promote Neovascularization in Doxorubicin-induced Cardiomyopathy .
7531516	0	FLK-2	0,5	FLT-3_ligand	6,18	FLK-2	FLT-3 ligand	2322	2323	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	FLK-2 / FLT-3_ligand regulates the growth of early myeloid progenitors isolated from human fetal liver .
9521912	0	FLK1	68,72	VE-cadherin	73,84	FLK1	VE-cadherin	16542(Tax:10090)	12562(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Progressive lineage analysis by cell sorting and culture identifies FLK1 + VE-cadherin + cells at a diverging point of endothelial and hemopoietic lineages .
25614868	0	FLNA	89,93	filamin_A	78,87	FLNA	filamin A	2316	2316	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Terminal_osseous_dysplasia_with_pigmentary_defects -LRB- TODPD -RRB- due to a recurrent filamin_A -LRB- FLNA -RRB- mutation .
26804200	0	FLNA	142,146	filamin_A	131,140	FLNA	filamin A	2316	2316	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A distinct X-linked_syndrome involving joint_contractures , keloids , large optic cup-to-disc ratio , and renal_stones results from a filamin_A -LRB- FLNA -RRB- mutation .
26929074	0	FLNC	31,35	HSPB7	0,5	FLNC	HSPB7	68794(Tax:10090)	29818(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles .
10623592	0	FLO11	42,47	GPR1	0,4	FLO11	GPR1	854836(Tax:4932)	851527(Tax:4932)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	GPR1 regulates filamentous growth through FLO11 in yeast Saccharomyces_cerevisiae .
11973282	0	FLOWER1	43,50	LEAFY	15,20	FLOWER1	LEAFY	829845(Tax:3702)	836307(Tax:3702)	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of LEAFY , AGAMOUS and TERMINAL FLOWER1 in maintaining floral meristem identity in Arabidopsis .
16236152	0	FLOWERING_LOCUS_C	22,39	FLC	41,44	FLOWERING LOCUS C	FLC	830878(Tax:3702)	830878(Tax:3702)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The downregulation of FLOWERING_LOCUS_C -LRB- FLC -RRB- expression in plants with low levels of DNA methylation and by vernalization occurs by distinct mechanisms .
21398257	0	FLOWERING_LOCUS_D	36,53	HISTONE_DEACETYLASE6	0,20	FLOWERING LOCUS D	HISTONE DEACETYLASE6	820202(Tax:3702)	836431(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HISTONE_DEACETYLASE6 interacts with FLOWERING_LOCUS_D and regulates flowering in Arabidopsis .
22195028	0	FLOWERING_LOCUS_T	29,46	GmFT2a	0,6	FLOWERING LOCUS T	GmFT2a	100814951	100814951	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	GmFT2a , a soybean homolog of FLOWERING_LOCUS_T , is involved in flowering transition and maintenance .
24718312	0	FLOWERING_LOCUS_T1	20,38	FT1	40,43	FLOWERING LOCUS T1	FT1	100838275	100838275	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of FLOWERING_LOCUS_T1 -LRB- FT1 -RRB- gene in brachypodium and wheat .
18086556	0	FLR1	59,63	Yap1	96,100	FLR1	Yap1	852293(Tax:4932)	855005(Tax:4932)	Gene	Gene	up-regulation|nmod|START_ENTITY involves|dobj|up-regulation involves|nmod|control control|nmod|END_ENTITY	Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1 , Rpn4 , Pdr3 , and Yrr1 .
12970321	0	FLRG	26,30	Follistatin-related_gene	0,24	FLRG	Follistatin-related gene	10272	10272	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Follistatin-related_gene -LRB- FLRG -RRB- expression in human endometrium : sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells .
11274757	0	FLRG	14,18	TGF-beta	62,70	FLRG	TGF-beta	10272	7040	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of FLRG , a novel activin A ligand , is regulated by TGF-beta and during hematopoiesis -LSB- corrected -RSB- .
15130517	0	FLRG	64,68	follistatin-related_gene	38,62	FLRG	follistatin-related gene	10272	10272	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Human endometrium and decidua express follistatin-related_gene -LRB- FLRG -RRB- mRNA and peptide .
19492039	0	FLRT3	21,26	Unc5B	0,5	FLRT3	Unc5B	503672(Tax:8355)	100302095(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos .
10329444	0	FLT	149,152	vascular_endothelial_growth_factor	78,112	FLT	vascular endothelial growth factor	2321	7422	Gene	Gene	upregulation|nmod|START_ENTITY vitro|nmod|upregulation vitro|nmod|END_ENTITY	Inhibition of hepatic stellate cell contraction during activation in vitro by vascular_endothelial_growth_factor in association with upregulation of FLT tyrosine kinase receptor family , FLT-1 .
10194760	0	FLT-1	70,75	VEGF	121,125	FLT-1	VEGF	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	R1|appos|START_ENTITY R1|acl:relcl|important important|nmod|regulation regulation|nmod|activity activity|compound|END_ENTITY	Alternative splicing of vascular_endothelial_growth_factor _ -LRB- VEGF -RRB- - R1 -LRB- FLT-1 -RRB- pre-mRNA is important for the regulation of VEGF activity .
10544000	0	FLT-1	67,72	VEGF	76,80	FLT-1	VEGF	2321	7422	Gene	Gene	domain|nmod|START_ENTITY loop|nmod|domain loop|appos|receptor receptor|amod|END_ENTITY	The fourth immunoglobulin-like loop in the extracellular domain of FLT-1 , a VEGF receptor , includes a major heparin-binding site .
11817706	0	FLT-1	90,95	VEGF	61,65	FLT-1	VEGF	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Monoclonal antibodies to vascular_endothelial_growth_factor -LRB- VEGF -RRB- and the VEGF receptor , FLT-1 , inhibit the growth of C6_glioma in a mouse xenograft .
12560388	0	FLT-1	99,104	VEGF	75,79	FLT-1	VEGF	2321	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression and prognostic relevance of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor -LRB- FLT-1 -RRB- in nephroblastoma .
14987558	0	FLT-1	34,39	VEGF	17,21	FLT-1	VEGF	2321	7422	Gene	Gene	Functions|appos|START_ENTITY Functions|nmod|receptor-1 receptor-1|compound|END_ENTITY	Functions of the VEGF receptor-1 -LRB- FLT-1 -RRB- in the vasculature .
16249383	0	FLT-1	9,14	VEGFR-1	0,7	FLT-1	VEGFR-1	2321	2321	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	VEGFR-1 -LRB- FLT-1 -RRB- activation modulates acute_lymphoblastic_leukemia localization and survival within the bone marrow , determining the onset of extramedullary disease .
9393770	0	FLT-1	89,94	Vascular_endothelial_growth_factor	0,34	FLT-1	Vascular endothelial growth factor	2321	7422	Gene	Gene	receptor|appos|START_ENTITY up-regulates|dobj|receptor up-regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor up-regulates its receptor fms-like_tyrosine_kinase_1 -LRB- FLT-1 -RRB- and a soluble variant of FLT-1 in human vascular endothelial cells .
9393770	0	FLT-1	89,94	fms-like_tyrosine_kinase_1	61,87	FLT-1	fms-like tyrosine kinase 1	2321	2321	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Vascular_endothelial_growth_factor up-regulates its receptor fms-like_tyrosine_kinase_1 -LRB- FLT-1 -RRB- and a soluble variant of FLT-1 in human vascular endothelial cells .
10329444	0	FLT-1	186,191	vascular_endothelial_growth_factor	78,112	FLT-1	vascular endothelial growth factor	2321	7422	Gene	Gene	stellate|xcomp|START_ENTITY stellate|nmod|activation activation|nmod|family family|amod|vitro vitro|nmod|END_ENTITY	Inhibition of hepatic stellate cell contraction during activation in vitro by vascular_endothelial_growth_factor in association with upregulation of FLT tyrosine kinase receptor family , FLT-1 .
11026652	0	FLT-1	91,96	vascular_endothelial_growth_factor	14,48	FLT-1	vascular endothelial growth factor	2321	7422	Gene	Gene	gene|compound|START_ENTITY Inhibition|nmod|gene Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of vascular_endothelial_growth_factor activity by transfection with the soluble FLT-1 gene .
12494887	0	FLT-1	94,99	vascular_endothelial_growth_factor	37,71	FLT-1	vascular endothelial growth factor	2321	7422	Gene	Gene	VEGFR-1|appos|START_ENTITY VEGFR-1|compound|END_ENTITY	Modulation of human NK cell lines by vascular_endothelial_growth_factor and receptor VEGFR-1 -LRB- FLT-1 -RRB- .
14674128	0	FLT-1	138,143	vascular_endothelial_growth_factor	49,83	FLT-1	vascular endothelial growth factor	2321	7422	Gene	Gene	Correlation|dep|START_ENTITY Correlation|nmod|activity activity|nmod|END_ENTITY	-LSB- Correlation between transcriptional activity of vascular_endothelial_growth_factor -LRB- VEFG -RRB- and transcriptional activity of its receptors -LRB- FLT-1 and FLK-1 -RRB- in low-grade squamous intraepithelial_lesions -LRB- LSIL -RRB- of uterine cervix -RSB- .
16269656	0	FLT-1	90,95	vascular_endothelial_growth_factor	8,42	FLT-1	vascular endothelial growth factor	2321	7422	Gene	Gene	downregulation|nmod|START_ENTITY mediates|dobj|downregulation mediates|nsubj|receptor-1 receptor-1|compound|END_ENTITY	Soluble vascular_endothelial_growth_factor receptor-1 -LRB- sFLT-1 -RRB- mediates downregulation of FLT-1 and prevents activated neutrophils from women with preeclampsia from additional migration by VEGF .
10541969	0	FLT-1_and_KDR	87,100	vascular_endothelial_growth_factor	34,68	FLT-1 and KDR	vascular endothelial growth factor	2321;3791	7422	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Melanoma-associated expression of vascular_endothelial_growth_factor and its receptors FLT-1_and_KDR .
25523287	0	FLT-3	95,100	MK-0888	76,83	FLT-3	MK-0888	2322	1476989(Tax:190192)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888 , a VEGFR-2 / FLT-3 kinase inhibitor .
25523287	0	FLT-3	95,100	VEGFR-2	87,94	FLT-3	VEGFR-2	2322	3791	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888 , a VEGFR-2 / FLT-3 kinase inhibitor .
7531516	0	FLT-3_ligand	6,18	FLK-2	0,5	FLT-3 ligand	FLK-2	2323	2322	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	FLK-2 / FLT-3_ligand regulates the growth of early myeloid progenitors isolated from human fetal liver .
19276374	0	FLT1	89,93	VEGFR-1	81,88	FLT1	VEGFR-1	2321	2321	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1 / FLT1 in leukemic_cancer cells .
25597754	0	FLT3	4,8	ABCB1	91,96	FLT3	ABCB1	2322	5243	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations .
23340802	0	FLT3	24,28	C/EBPa	0,6	FLT3	C/EBPa	2322	1050	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	C/EBPa and MYB regulate FLT3 expression in AML .
9529123	0	FLT3	0,4	CBL	47,50	FLT3	CBL	2322	867	Gene	Gene	involves|nsubj|START_ENTITY involves|dobj|END_ENTITY	FLT3 signaling in hematopoietic cells involves CBL , SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates .
9207445	0	FLT3	92,96	CD135	98,103	FLT3	CD135	2322	2322	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 -LRB- CD135 -RRB- receptor tyrosine kinase .
19754199	0	FLT3	231,235	FMS-like_tyrosine_kinase-3	203,229	FLT3	FMS-like tyrosine kinase-3	2322	2322	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Identification of N - -LRB- 5-tert-butyl-isoxazol-3-yl -RRB- - N ' - -LCB- 4 - -LSB- 7 - -LRB- 2-morpholin-4-yl-ethoxy -RRB- imidazo -LSB- 2,1-b -RSB- -LSB- 1,3 -RSB- benzothiazol-2-yl -RSB- phenyl -RCB- urea_dihydrochloride -LRB- AC220 -RRB- , a uniquely potent , selective , and efficacious FMS-like_tyrosine_kinase-3 -LRB- FLT3 -RRB- inhibitor .
12973844	0	FLT3	84,88	FMS-like_tyrosine_kinase_3	56,82	FLT3	FMS-like tyrosine kinase 3	2322	2322	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Internal tandem duplication and Asp835 mutations of the FMS-like_tyrosine_kinase_3 -LRB- FLT3 -RRB- gene in acute_promyelocytic_leukemia .
26896780	0	FLT3	28,32	FMS-like_tyrosine_kinase_3	0,26	FLT3	FMS-like tyrosine kinase 3	14255(Tax:10090)	14255(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	FMS-like_tyrosine_kinase_3 -LRB- FLT3 -RRB- inhibitors : Molecular docking and experimental studies .
8562934	0	FLT3	55,59	Flk2	67,71	FLT3	Flk2	2322	2322	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the hematopoietic growth factor receptor FLT3 -LRB- STK-1 / Flk2 -RRB- in human leukemias .
24855211	0	FLT3	10,14	ITD	15,18	FLT3	ITD	2322	2322	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of FLT3 -LRB- ITD -RRB- mutant allele level on relapse risk in intermediate-risk acute_myeloid_leukemia .
12620411	0	FLT3	14,18	MLL	22,25	FLT3	MLL	14255(Tax:10090)	214162(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of FLT3 in MLL .
18024407	0	FLT3	30,34	MLL	43,46	FLT3	MLL	2322	4297	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid_acute_lymphoblastic_leukemia .
15755900	0	FLT3	32,36	Meis1	0,5	FLT3	Meis1	2322	4211	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Meis1 programs transcription of FLT3 and cancer stem cell character , using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus .
17768124	0	FLT3	36,40	NPM1	0,4	FLT3	NPM1	2322	4869	Gene	Gene	mutations|nummod|START_ENTITY stable|nmod|mutations stable|nsubj|mutations mutations|compound|END_ENTITY	NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute_myeloid_leukemia .
17957027	0	FLT3	14,18	NPM1	96,100	FLT3	NPM1	2322	4869	Gene	Gene	duplication|compound|START_ENTITY impact|nmod|duplication mutant|nsubj|impact mutant|dobj|level level|nmod|mutations mutations|nummod|END_ENTITY	The impact of FLT3 internal tandem duplication mutant level , number , size , and interaction with NPM1 mutations in a large cohort of young adult patients with acute_myeloid_leukemia .
20567020	0	FLT3	188,192	NPM1	166,170	FLT3	NPM1	2322	4869	Gene	Gene	duplication|compound|START_ENTITY confer|nmod|duplication confer|nmod|acute_myeloid_leukemia acute_myeloid_leukemia|nmod|mutation mutation|compound|END_ENTITY	IDH1 and IDH2 mutations are frequent genetic alterations in acute_myeloid_leukemia and confer adverse prognosis in cytogenetically normal acute_myeloid_leukemia with NPM1 mutation without FLT3 internal tandem duplication .
21338238	0	FLT3	26,30	NPM1	53,57	FLT3	NPM1	2322	4869	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Fms like tyrosine kinase -LRB- FLT3 -RRB- and nucleophosmin_1 -LRB- NPM1 -RRB- mutations in de novo normal karyotype acute_myeloid_leukemia -LRB- AML -RRB- .
26410460	0	FLT3	36,40	NPM1	30,34	FLT3	NPM1	2322	4869	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Prognostic impact of combined NPM1 + / FLT3 - genotype in patients with acute_myeloid_leukemia with intermediate risk cytogenetics stratified by age and treatment modalities .
20137111	0	FLT3	99,103	Npm1	26,30	FLT3	Npm1	2322	4869	Gene	Gene	-RSB-|compound|START_ENTITY mutation|nmod|-RSB- mutations|nmod|mutation mutations|nsubj|Correlation Correlation|nmod|END_ENTITY	-LSB- Correlation of adult_AML Npm1 mutations with prognosis and its relationship with gene mutation of FLT3 and CEBPA -RSB- .
24040307	0	FLT3	51,55	Pim-1	0,5	FLT3	Pim-1	2322	5292	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|kinase kinase|amod|END_ENTITY	Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute_myeloid_leukemia with FLT3 internal tandem duplication .
24525236	0	FLT3	31,35	SYK	0,3	FLT3	SYK	2322	6850	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	SYK is a critical regulator of FLT3 in acute_myeloid_leukemia .
25456130	0	FLT3	49,53	Stat5	14,19	FLT3	Stat5	14255(Tax:10090)	20850(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3 - and KIT-Driven Leukemogenesis .
17851558	0	FLT3	0,4	beta-catenin	15,27	FLT3	beta-catenin	2322	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	FLT3 regulates beta-catenin tyrosine phosphorylation , nuclear localization , and transcriptional activity in acute_myeloid_leukemia cells .
7789184	0	FLT3	60,64	stem_cell_tyrosine_kinase-1	26,53	FLT3	stem cell tyrosine kinase-1	2322	2322	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human stem_cell_tyrosine_kinase-1 gene -LRB- FLT3 -RRB- to 13q12 -- > q13 .
14670916	0	FLT3-ligand	31,42	Thrombopoietin	0,14	FLT3-ligand	Thrombopoietin	2323	7066	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors .
10923402	0	FLT3_ligand	29,40	CD34	90,94	FLT3 ligand	CD34	2323	947	Gene	Gene	START_ENTITY|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	-LSB- Effect of recombinant human FLT3_ligand -LRB- rhFL -RRB- on in vitro expansion of human cord blood CD34 + cells -RSB- .
24947444	0	FLVCR1	63,69	LRP1	24,28	FLVCR1	LRP1	28982	4035	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status .
10783389	0	FM-3	94,98	neuromedin_U	18,30	FM-3	neuromedin U	10316	10874	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|Identification Identification|nmod|END_ENTITY	Identification of neuromedin_U as the cognate ligand of the orphan G protein-coupled receptor FM-3 .
10811630	0	FM3	74,77	Neuromedin_U	0,12	FM3	Neuromedin U	10316	10874	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	Neuromedin_U is a potent agonist at the orphan G protein-coupled receptor FM3 .
2141826	0	FMLP	46,50	f-Met-Leu-Phe	31,44	FMLP	f-Met-Leu-Phe	2357	2357	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of chemotactic peptide f-Met-Leu-Phe -LRB- FMLP -RRB- on C3b_receptor -LRB- CR1 -RRB- expression and phagocytosis of microspheres by human neutrophils .
11756198	0	FMLP	69,73	granulocyte-colony-stimulating_factor	138,175	FMLP	granulocyte-colony-stimulating factor	2357	1440	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Liposomal amphotericin_B -LRB- AmBisome -RRB- compared with amphotericin_B + / - FMLP induces significantly less in vitro neutrophil aggregation with granulocyte-colony-stimulating_factor / dexamethasone-mobilized allogeneic donor neutrophils .
1612600	0	FMLP_receptor	87,100	FPRH1	129,134	FMLP receptor	FPRH1	2357	2359	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Mapping of genes for the human C5a_receptor -LRB- C5AR -RRB- , human FMLP_receptor -LRB- FPR -RRB- , and two FMLP_receptor homologue orphan receptors -LRB- FPRH1 , FPRH2 -RRB- to chromosome 19 .
20599799	0	FMLP_receptor	43,56	SMG-1	24,29	FMLP receptor	SMG-1	2357	23049	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nsubj|END_ENTITY	The hederagenin_saponin SMG-1 is a natural FMLP_receptor inhibitor that suppresses human neutrophil activation .
18980384	0	FMN	44,47	methionine_synthase_reductase	65,94	FMN	methionine synthase reductase	342184	4552	Gene	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Impeded electron transfer from a pathogenic FMN domain mutant of methionine_synthase_reductase and its responsiveness to flavin supplementation .
15866570	0	FMN2	62,66	formin-2	52,60	FMN2	formin-2	56776	56776	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization and mutation analysis of the human formin-2 -LRB- FMN2 -RRB- gene in women with unexplained_infertility .
23375502	0	FMN2	50,54	p21	109,112	FMN2	p21	56776	1026	Gene	Gene	characterization|nmod|START_ENTITY inhibitor|nsubj|characterization inhibitor|dobj|END_ENTITY	Identification and functional characterization of FMN2 , a regulator of the cyclin-dependent kinase inhibitor p21 .
23839046	0	FMN2	0,4	p21	67,70	FMN2	p21	56776	644914	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21 .
26083584	0	FMNL1	14,19	GM130	30,35	FMNL1	GM130	57778(Tax:10090)	99412(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis .
26103003	0	FMNL2	21,26	MicroRNA-34a	0,12	FMNL2	MicroRNA-34a	114793	407040	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal_cancer .
16531493	0	FMO1	143,147	ENHANCED_DISEASE_SUSCEPTIBILITY1	27,59	FMO1	ENHANCED DISEASE SUSCEPTIBILITY1	838508(Tax:3702)	823964(Tax:3702)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Salicylic_acid-independent ENHANCED_DISEASE_SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7 .
9509414	0	FMO1	46,50	flavin-containing_monooxygenase	13,44	FMO1	flavin-containing monooxygenase	25256(Tax:10116)	25256(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of flavin-containing_monooxygenase -LRB- FMO1 -RRB- by a polycyclic_aromatic_hydrocarbon , 3-methylcholanthrene , in rat liver .
12829732	0	FMO1	111,115	yin_yang_1	78,88	FMO1	yin yang 1	2326	7528	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Genetic variability at the human FMO1 locus : significance of a basal promoter yin_yang_1 element polymorphism -LRB- FMO1 * 6 -RRB- .
9804831	0	FMO2	44,48	flavin-containing_monooxygenase_2	4,37	FMO2	flavin-containing monooxygenase 2	2327	2327	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The flavin-containing_monooxygenase_2 gene -LRB- FMO2 -RRB- of humans , but not of other primates , encodes a truncated , nonfunctional protein .
16324215	0	FMO3	56,60	Flavin_containing_monooxygenase_3	21,54	FMO3	Flavin containing monooxygenase 3	2328	2328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of the Flavin_containing_monooxygenase_3 -LRB- FMO3 -RRB- gene do not predispose to essential hypertension in Caucasians .
9398858	0	FMO3	62,66	flavin-containing_mono-oxygenase_3	21,55	FMO3	flavin-containing mono-oxygenase 3	2328	2328	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Missense mutation in flavin-containing_mono-oxygenase_3 gene , FMO3 , underlies fish-odour_syndrome .
17885620	0	FMO3	91,95	flavin-containing_monooxygenase_3	51,84	FMO3	flavin-containing monooxygenase 3	2328	2328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular evolution and balancing selection in the flavin-containing_monooxygenase_3 gene -LRB- FMO3 -RRB- .
18305374	0	FMO3	106,110	flavin-containing_monooxygenase_3	71,104	FMO3	flavin-containing monooxygenase 3	2328	2328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Complex mechanism underlying transcriptional control of the haplotyped flavin-containing_monooxygenase_3 -LRB- FMO3 -RRB- gene in Japanese : different regulation between mutations in 5 ' - upstream distal region and common element in proximal region .
19321370	0	FMO3	63,67	flavin-containing_monooxygenase_3	28,61	FMO3	flavin-containing monooxygenase 3	2328	2328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel variants of the human flavin-containing_monooxygenase_3 -LRB- FMO3 -RRB- gene associated with trimethylaminuria .
19577495	0	FMO3	64,68	flavin-containing_monooxygenase_3	24,57	FMO3	flavin-containing monooxygenase 3	2328	2328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the flavin-containing_monooxygenase_3 gene -LRB- FMO3 -RRB- of a Norwegian family causes trimethylaminuria .
9417913	0	FMO3	77,81	flavin-containing_monooxygenase_3	37,70	FMO3	flavin-containing monooxygenase 3	2328	2328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural organization of the human flavin-containing_monooxygenase_3 gene -LRB- FMO3 -RRB- , the favored candidate for fish-odor_syndrome , determined directly from genomic DNA .
26616280	0	FMO3	132,136	hepatic_Flavin-containing_monooxygenase-3	89,130	FMO3	hepatic Flavin-containing monooxygenase-3	2328	2328	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic_Flavin-containing_monooxygenase-3 -LRB- FMO3 -RRB- gene expression in HepG2 cells .
23874213	0	FMR1	35,39	CTCF	8,12	FMR1	CTCF	2332	10664	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Role of CTCF protein in regulating FMR1 locus transcription .
15175277	0	FMR1	44,48	Nrf-1	61,66	FMR1	Nrf-1	2332	4899	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Occupancy and synergistic activation of the FMR1 promoter by Nrf-1 and Sp1 in vivo .
22065534	0	FMR2	42,46	AFF2	36,40	FMR2	AFF2	2481	2334	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Microdeletion of Xq28 involving the AFF2 -LRB- FMR2 -RRB- gene in two unrelated males with developmental_delay .
9300465	0	FMRF_amide-related_peptides	39,66	FaRPs	68,73	FMRF amide-related peptides	FaRPs	64111	64111	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Physiological effects of platyhelminth FMRF_amide-related_peptides -LRB- FaRPs -RRB- on the motility of the monogenean Diclidophora merlangi .
7980835	0	FMRFamide-related_peptides	28,54	FaRPs	56,61	FMRFamide-related peptides	FaRPs	64111	64111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of mRNA encoding FMRFamide-related_peptides -LRB- FaRPs -RRB- in the nervous system of Helix aspersa .
22867433	0	FMRP	35,39	CREB	9,13	FMRP	CREB	14265(Tax:10090)	12912(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY Roles|nmod|regulation Roles|nmod|END_ENTITY	Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex .
22863780	0	FMRP	21,25	DSCR1	0,5	FMRP	DSCR1	2332	1827	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis .
22909818	0	FMRP	77,81	DSCR1	14,19	FMRP	DSCR1	2332	1827	Gene	Gene	START_ENTITY|nmod|causes causes|compound|END_ENTITY	Down syndrome DSCR1 causes spine pathology via the Fragile X-related protein FMRP .
19155329	0	FMRP	19,23	Dicer	50,55	FMRP	Dicer	2332	23405	Gene	Gene	Phosphorylation|nmod|START_ENTITY inhibits|nsubj|Phosphorylation inhibits|nmod|END_ENTITY	Phosphorylation of FMRP inhibits association with Dicer .
14613971	0	FMRP	27,31	FMRP	84,88	FMRP	FMRP	2332	2332	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Developmentally-programmed FMRP expression in oligodendrocytes : a potential role of FMRP in regulating translation in oligodendroglia progenitors .
14613971	0	FMRP	84,88	FMRP	27,31	FMRP	FMRP	2332	2332	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Developmentally-programmed FMRP expression in oligodendrocytes : a potential role of FMRP in regulating translation in oligodendroglia progenitors .
26051932	0	FMRP	19,23	GluA1	51,56	FMRP	GluA1	14265(Tax:10090)	14799(Tax:10090)	Gene	Gene	START_ENTITY|dep|Expression Expression|compound|END_ENTITY	Fragile_X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms .
22579290	0	FMRP	60,64	NOS1	52,56	FMRP	NOS1	57532	4842	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex .
24338128	0	FMRP	50,54	NeuroD1	28,35	FMRP	NeuroD1	24948(Tax:10116)	29458(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Translational regulation of NeuroD1 expression by FMRP : involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cells .
18474609	0	FMRP	72,76	mammalian_target_of_rapamycin	124,153	FMRP	mammalian target of rapamycin	2332	2475	Gene	Gene	fragile_X_mental_retardation_protein|appos|START_ENTITY fragile_X_mental_retardation_protein|nmod|END_ENTITY	S6K1 phosphorylates and regulates fragile_X_mental_retardation_protein -LRB- FMRP -RRB- with the neuronal protein synthesis-dependent mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling cascade .
21658607	0	FMRP	62,66	miR-125a	52,60	FMRP	miR-125a	2332	406910	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Reversible inhibition of PSD-95 mRNA translation by miR-125a , FMRP phosphorylation , and mGluR signaling .
19754199	0	FMS-like_tyrosine_kinase-3	203,229	FLT3	231,235	FMS-like tyrosine kinase-3	FLT3	2322	2322	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Identification of N - -LRB- 5-tert-butyl-isoxazol-3-yl -RRB- - N ' - -LCB- 4 - -LSB- 7 - -LRB- 2-morpholin-4-yl-ethoxy -RRB- imidazo -LSB- 2,1-b -RSB- -LSB- 1,3 -RSB- benzothiazol-2-yl -RSB- phenyl -RCB- urea_dihydrochloride -LRB- AC220 -RRB- , a uniquely potent , selective , and efficacious FMS-like_tyrosine_kinase-3 -LRB- FLT3 -RRB- inhibitor .
12973844	0	FMS-like_tyrosine_kinase_3	56,82	FLT3	84,88	FMS-like tyrosine kinase 3	FLT3	2322	2322	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Internal tandem duplication and Asp835 mutations of the FMS-like_tyrosine_kinase_3 -LRB- FLT3 -RRB- gene in acute_promyelocytic_leukemia .
26896780	0	FMS-like_tyrosine_kinase_3	0,26	FLT3	28,32	FMS-like tyrosine kinase 3	FLT3	14255(Tax:10090)	14255(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	FMS-like_tyrosine_kinase_3 -LRB- FLT3 -RRB- inhibitors : Molecular docking and experimental studies .
20508617	0	FMS-like_tyrosine_kinase_3	41,67	UBCH8	20,25	FMS-like tyrosine kinase 3	UBCH8	2322	9246	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Ubiquitin conjugase UBCH8 targets active FMS-like_tyrosine_kinase_3 for proteasomal degradation .
21262836	0	FMS-like_tyrosine_kinase_3_receptor	23,58	flt3L	67,72	FMS-like tyrosine kinase 3 receptor	flt3L	14256(Tax:10090)	14256(Tax:10090)	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	Interleukin-2 inhibits FMS-like_tyrosine_kinase_3_receptor ligand -LRB- flt3L -RRB- - dependent development and function of conventional and plasmacytoid dendritic cells .
26964871	0	FN1	30,33	HMGA2	46,51	FN1	HMGA2	2335	8091	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal_cancer .
24390218	0	FN1	37,40	MITF	46,50	FN1	MITF	2335	4286	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	A novel hypoxia-associated subset of FN1 high MITF low melanoma cells : identification , characterization , and prognostic value .
24120943	0	FNDC5	51,56	PGC-1a	44,50	FNDC5	PGC-1a	384061(Tax:10090)	19017(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Exercise induces hippocampal BDNF through a PGC-1a / FNDC5 pathway .
25427998	0	FNDC5	0,5	irisin	7,13	FNDC5	irisin	252995	252995	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	FNDC5 -LRB- irisin -RRB- gene and exceptional longevity : a functional replication study with rs16835198 and rs726344 SNPs .
25112714	0	FNDC5	0,5	leptin	28,34	FNDC5	leptin	252995	3952	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	FNDC5 could be regulated by leptin in adipose tissue .
15507435	0	FOG	33,36	Friend_of_GATA	17,31	FOG	Friend of GATA	161882	161882	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	The N termini of Friend_of_GATA -LRB- FOG -RRB- proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors .
21047798	0	FOG-1	98,103	RbAp48	90,96	FOG-1	RbAp48	161882	5928	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48 FOG-1 complex .
18063754	0	FOG-1	60,65	friend_of_GATA-1	42,58	FOG-1	friend of GATA-1	22761(Tax:10090)	22761(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Differential context-dependent effects of friend_of_GATA-1 -LRB- FOG-1 -RRB- on mast-cell development and differentiation .
19729519	0	FOG-1	45,50	friend_of_GATA-1	27,43	FOG-1	friend of GATA-1	407655(Tax:7955)	407655(Tax:7955)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role and regulation of friend_of_GATA-1 -LRB- FOG-1 -RRB- during blood development in the zebrafish .
15220332	0	FOG-2	0,5	GATA-4	20,26	FOG-2	GATA-4	23414	2626	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes .
10801815	0	FOG-2	68,73	friend_of_GATA-2	50,66	FOG-2	friend of GATA-2	23414	23414	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	A functionally conserved N-terminal domain of the friend_of_GATA-2 -LRB- FOG-2 -RRB- protein represses GATA4-dependent transcription .
17309641	0	FOG-2	37,42	friend_of_GATA_2	14,30	FOG-2	friend of GATA 2	23414	23414	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disruption of friend_of_GATA_2 gene -LRB- FOG-2 -RRB- by a de novo t -LRB- 8 ; 10 -RRB- chromosomal translocation is associated with heart_defects and gonadal_dysgenesis .
11350116	0	FOLH1	75,80	prostate-specific_membrane_antigen	34,68	FOLH1	prostate-specific membrane antigen	2346	2346	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A tissue-specific enhancer of the prostate-specific_membrane_antigen gene , FOLH1 .
23528302	0	FOLR1	19,24	Folate-receptor_1	0,17	FOLR1	Folate-receptor 1	2348	2348	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Folate-receptor_1 -LRB- FOLR1 -RRB- protein is elevated in the serum of ovarian_cancer patients .
9949182	0	FOP	97,100	fibroblast_growth_factor_receptor_1	105,140	FOP	fibroblast growth factor receptor 1	11116	2260	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The t -LRB- 6 ; 8 -RRB- -LRB- q27 ; p11 -RRB- translocation in a stem cell myeloproliferative_disorder fuses a novel gene , FOP , to fibroblast_growth_factor_receptor_1 .
8345107	0	FOS	5,8	JUN	0,3	FOS	JUN	314322(Tax:10116)	24516(Tax:10116)	Gene	Gene	transcription|nsubj|START_ENTITY transcription|advmod|END_ENTITY	JUN , FOS , KROX , and CREB transcription factor proteins in the rat cortex : basal expression and induction by spreading depression and epileptic_seizures .
19570917	0	FOS-1	23,28	plc-1	48,53	FOS-1	plc-1	178987(Tax:6239)	181274(Tax:6239)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Caenorhabditis_elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation .
8985116	0	FOSB	70,74	G0S3	81,85	FOSB	G0S3	2354	2354	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence analysis and expression in cultured lymphocytes of the human FOSB gene -LRB- G0S3 -RRB- .
22235402	0	FOSL1	53,58	AP-1	48,52	FOSL1	AP-1	8061	3725	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Effects of expression of transcriptional factor AP-1 FOSL1 gene on psoriatic process .
25375657	0	FOSL2	0,5	TGF-b1	27,33	FOSL2	TGF-b1	2355	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	FOSL2 positively regulates TGF-b1 signalling in non-small_cell_lung_cancer .
22326952	0	FOSL2	0,5	leptin	15,21	FOSL2	leptin	2355	3952	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	FOSL2 promotes leptin gene expression in human and mouse adipocytes .
17660359	0	FOX1	128,132	FEA1	0,4	FOX1	FEA1	5720109(Tax:3055)	5719589(Tax:3055)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	FEA1 , FEA2 , and FRE1 , encoding two homologous secreted proteins and a candidate ferrireductase , are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas_reinhardtii .
25008967	0	FOXA1	73,78	Androgen_receptor	0,17	FOXA1	Androgen receptor	3169	367	Gene	Gene	genes|nummod|START_ENTITY regulate|dobj|genes regulate|nsubj|END_ENTITY	Androgen_receptor and its splice variant , AR-V7 , differentially regulate FOXA1 sensitive genes in LNCaP_prostate_cancer cells .
24292680	0	FOXA1	19,24	androgen_receptor	36,53	FOXA1	androgen receptor	3169	367	Gene	Gene	levels|nmod|START_ENTITY facilitate|nsubj|levels facilitate|xcomp|resulting resulting|nsubj|chromatin chromatin|compound|END_ENTITY	Elevated levels of FOXA1 facilitate androgen_receptor chromatin binding resulting in a CRPC-like phenotype .
24875621	0	FOXA1	35,40	androgen_receptor	52,69	FOXA1	androgen receptor	3169	367	Gene	Gene	Cooperativity|nmod|START_ENTITY define|nsubj|Cooperativity define|dobj|program program|compound|END_ENTITY	Cooperativity and equilibrium with FOXA1 define the androgen_receptor transcriptional program .
24948874	0	FOXA1	35,40	androgen_receptor	14,31	FOXA1	androgen receptor	3169	367	Gene	Gene	factors|compound|START_ENTITY Modulation|nmod|factors Modulation|nmod|END_ENTITY	Modulation of androgen_receptor by FOXA1 and FOXO1 factors in prostate_cancer .
26114156	0	FOXA1	24,29	androgen_receptor	44,61	FOXA1	androgen receptor	3169	367	Gene	Gene	regulation|compound|START_ENTITY perspectives|nmod|regulation perspectives|nmod|signaling signaling|compound|END_ENTITY	Current perspectives on FOXA1 regulation of androgen_receptor signaling and prostate_cancer .
26336819	0	FOXA1	0,5	androgen_receptor	16,33	FOXA1	androgen receptor	3169	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	FOXA1 regulates androgen_receptor variant activity in models of castrate-resistant_prostate_cancer .
23443045	0	FOXA1	0,5	p16	15,18	FOXA1	p16	3169	1029	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	FOXA1 mediates p16 -LRB- INK4a -RRB- activation during cellular senescence .
25667220	0	FOXA2	58,63	CYP2A13	24,31	FOXA2	CYP2A13	3170	1553	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2 , and their genetic interaction is associated with lung_cancer .
20074681	0	FOXA2	33,38	SOX14	52,57	FOXA2	SOX14	3170	8403	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression .
26065367	0	FOXC1	36,41	CXCR1	73,78	FOXC1	CXCR1	17300(Tax:10090)	227288(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Interleukin-8 Induces Expression of FOXC1 to Promote Trans-activation of CXCR1 and CCL2 in Hepatocellular_Carcinoma Cell Lines and Formation of Metastases in Mice .
27041579	0	FOXC1	0,5	ERa	21,24	FOXC1	ERa	2296	2099	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	FOXC1 is involved in ERa silencing by counteracting GATA3 binding and is implicated in endocrine resistance .
26065367	0	FOXC1	36,41	Interleukin-8	0,13	FOXC1	Interleukin-8	17300(Tax:10090)	20309(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Interleukin-8 Induces Expression of FOXC1 to Promote Trans-activation of CXCR1 and CCL2 in Hepatocellular_Carcinoma Cell Lines and Formation of Metastases in Mice .
26198045	0	FOXC1	27,32	MicroRNA-495	0,12	FOXC1	MicroRNA-495	2296	574453	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial_cancer .
26198045	0	FOXC1	27,32	MicroRNA-495	0,12	FOXC1	MicroRNA-495	2296	574453	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial_cancer .
23145080	0	FOXC1	111,116	Msx2	103,107	FOXC1	Msx2	17300(Tax:10090)	17702(Tax:10090)	Gene	Gene	differentiation|nmod|START_ENTITY differentiation|nmod|regulation regulation|nmod|END_ENTITY	Initiation of early osteoblast differentiation events through the direct transcriptional regulation of Msx2 by FOXC1 .
15477465	0	FOXC1	66,71	forkhead_box_C1	49,64	FOXC1	forkhead box C1	2296	2296	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Axenfeld-Rieger_anomaly : a novel mutation in the forkhead_box_C1 -LRB- FOXC1 -RRB- gene in a 4-generation family .
26585487	0	FOXC1	106,111	miR-4792	0,8	FOXC1	miR-4792	2296	100616448	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-4792 inhibits epithelial-mesenchymal transition and invasion in nasopharyngeal_carcinoma by targeting FOXC1 .
25130698	0	FOXC1	134,139	miR-639	0,7	FOXC1	miR-639	2296	693224	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-639 regulates transforming_growth_factor_beta-induced epithelial-mesenchymal transition in human tongue_cancer cells by targeting FOXC1 .
22216698	0	FOXC2	42,47	mesenchyme_forkhead_1	19,40	FOXC2	mesenchyme forkhead 1	2303	2303	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression of mesenchyme_forkhead_1 -LRB- FOXC2 -RRB- significantly correlates with the degree of lymph_node_metastasis in colorectal_cancer .
20460685	0	FOXC2	51,56	p120-catenin	0,12	FOXC2	p120-catenin	14234(Tax:10090)	12388(Tax:10090)	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nsubjpass|END_ENTITY	p120-catenin is transcriptionally downregulated by FOXC2 in non-small_cell_lung_cancer cells .
19403660	0	FOXD3	0,5	MITF	108,112	FOXD3	MITF	15221(Tax:10090)	17342(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism .
26252164	0	FOXD3	0,5	PAX3	15,19	FOXD3	PAX3	27022	5077	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FOXD3 Promotes PAX3 Expression in Melanoma Cells .
26252164	0	FOXD3	0,5	PAX3	15,19	FOXD3	PAX3	27022	5077	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FOXD3 Promotes PAX3 Expression in Melanoma Cells .
16772323	0	FOXF1	21,26	growth_hormone	37,51	FOXF1	growth hormone	2294	2688	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transcription factor FOXF1 regulates growth_hormone variant gene expression .
27044840	0	FOXG1	89,94	MiR-200b	0,8	FOXG1	MiR-200b	2290	406984	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	MiR-200b promotes the cell proliferation and metastasis of cervical cancer by inhibiting FOXG1 .
24412290	0	FOXG1	35,40	forkhead_box_G1	18,33	FOXG1	forkhead box G1	2290	2290	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutation in forkhead_box_G1 -LRB- FOXG1 -RRB- gene in an Indian patient with Rett_syndrome .
11060460	0	FOXJ1	32,37	HFH-4	45,50	FOXJ1	HFH-4	2302	2302	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No deleterious mutations in the FOXJ1 -LRB- alias HFH-4 -RRB- gene in patients with primary ciliary_dyskinesia -LRB- PCD -RRB- .
16153597	0	FOXL2	23,28	DP103	44,49	FOXL2	DP103	668	11218	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis .
20650879	0	FOXL2	47,52	Mc2r	30,34	FOXL2	Mc2r	26927(Tax:10090)	17200(Tax:10090)	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Synergistic activation of the Mc2r promoter by FOXL2 and NR5A1 in mice .
24451388	0	FOXL2	0,5	Sf1	34,37	FOXL2	Sf1	26927(Tax:10090)	22668(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice .
21518729	0	FOXM1	21,26	ATM	0,3	FOXM1	ATM	2305	472	Gene	Gene	expression|nummod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	ATM and p53 regulate FOXM1 expression via E2F in breast_cancer epirubicin treatment and resistance .
20351091	0	FOXM1	17,22	EPS8	0,4	FOXM1	EPS8	2305	2059	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	EPS8 upregulates FOXM1 expression , enhancing cell growth and motility .
20208560	0	FOXM1	0,5	ERalpha	37,44	FOXM1	ERalpha	2305	2099	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	FOXM1 is a transcriptional target of ERalpha and has a critical role in breast_cancer endocrine sensitivity and resistance .
19276163	0	FOXM1	29,34	FOXO3a	50,56	FOXM1	FOXO3a	2305	2309	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Gefitinib -LRB- Iressa -RRB- represses FOXM1 expression via FOXO3a in breast_cancer .
24314213	0	FOXM1	40,45	FOXO3a	55,61	FOXM1	FOXO3a	2305	2309	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	-LSB- Effects of AG1478 on the expression of FOXM1 gene via FOXO3a in non-small cell lung_cancer cells -RSB- .
25411964	0	FOXM1	43,48	Forkhead_Box_Protein_M1	18,41	FOXM1	Forkhead Box Protein M1	2305	2305	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Forkhead_Box_Protein_M1 -LRB- FOXM1 -RRB- in Ovarian_Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance .
26619071	0	FOXM1	44,49	Forkhead_box_M1	27,42	FOXM1	Forkhead box M1	2305	2305	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of Forkhead_box_M1 -LRB- FOXM1 -RRB- expression and antitumor effect of FOXM1 inhibition in melanoma .
12183437	0	FOXM1	0,5	Gli1	32,36	FOXM1	Gli1	2305	2735	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	FOXM1 is a downstream target of Gli1 in basal_cell_carcinomas .
25961928	0	FOXM1	19,24	KIF20A	37,43	FOXM1	KIF20A	2305	10112	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|END_ENTITY	Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast_cancer paclitaxel resistance .
25961928	0	FOXM1	19,24	KIF20A	37,43	FOXM1	KIF20A	2305	10112	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|END_ENTITY	Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast_cancer paclitaxel resistance .
24141789	0	FOXM1	0,5	NBS1	14,18	FOXM1	NBS1	2305	4683	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance .
26404623	0	FOXM1	0,5	XIAP	14,18	FOXM1	XIAP	2305	331	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	FOXM1 targets XIAP and Survivin to modulate breast_cancer survival and chemoresistance .
26918606	0	FOXM1	0,5	eukaryotic_elongation_factor_2_kinase	30,67	FOXM1	eukaryotic elongation factor 2 kinase	2305	29904	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	FOXM1 regulates expression of eukaryotic_elongation_factor_2_kinase and promotes proliferation , invasion and tumorgenesis of human triple negative breast_cancer cells .
26722467	0	FOXM1	77,82	miR-204	0,7	FOXM1	miR-204	2305	406987	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-204 inhibits invasion and epithelial-mesenchymal transition by targeting FOXM1 in esophageal_cancer .
24999187	0	FOXM1	86,91	microRNA-24-1	19,32	FOXM1	microRNA-24-1	2305	407012	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Tumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder_cancer .
21518241	0	FOXO	68,72	Insulin_receptor	0,16	FOXO	Insulin receptor	41709(Tax:7227)	42549(Tax:7227)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Insulin_receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan .
17510058	0	FOXO1	0,5	4E-BP1	34,40	FOXO1	4E-BP1	2308	1978	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle .
21097394	0	FOXO1	52,57	AMPK	12,16	FOXO1	AMPK	84482(Tax:10116)	78975(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	-LSB- Effects of AMPK on the transcriptional activity of FOXO1 and ubiquitin ligase MuRF1 expression in rat cardiomyocytes -RSB- .
16670089	0	FOXO1	126,131	Akt	76,79	FOXO1	Akt	2308	207	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|compound|END_ENTITY	C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1 .
22240809	0	FOXO1	0,5	CCL20	16,21	FOXO1	CCL20	2308	6364	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	FOXO1 increases CCL20 to promote NF-kB-dependent lymphocyte chemotaxis .
18356527	0	FOXO1	14,19	Cdk1	23,27	FOXO1	Cdk1	2308	983	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons .
17482685	0	FOXO1	30,35	E2F-1	0,5	FOXO1	E2F-1	84482(Tax:10116)	399489(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	E2F-1 regulates expression of FOXO1 and FOXO3a .
16020479	0	FOXO1	38,43	FKHR	45,49	FOXO1	FKHR	84482(Tax:10116)	84482(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the proapoptotic factor FOXO1 -LRB- FKHR -RRB- in cardiomyocytes by growth factors and alpha1-adrenergic agonists .
18303411	0	FOXO1	13,18	FKHR	20,24	FOXO1	FKHR	2308	2308	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of FOXO1 -LRB- FKHR -RRB- gene break-apart by fluorescence in situ hybridization in formalin-fixed , paraffin-embedded alveolar_rhabdomyosarcomas and its clinicopathologic correlation .
19772960	0	FOXO1	21,26	FKHR	15,19	FOXO1	FKHR	2308	2308	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of FKHR -LRB- FOXO1 -RRB- transcription factor in human uterus_leiomyoma growth .
23133314	0	FOXO1	0,5	FOXO1	78,83	FOXO1	FOXO1	2308	2308	Gene	Gene	Expression|compound|START_ENTITY Expression|dep|Binding Binding|nmod|Motif Motif|compound|END_ENTITY	FOXO1 Up-Regulates Human L-selectin Expression Through Binding to a Consensus FOXO1 Motif .
23241886	0	FOXO1	42,47	Fam65b	0,6	FOXO1	Fam65b	2308	9750	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration .
23918930	0	FOXO1	17,22	Forkhead_box_O1	0,15	FOXO1	Forkhead box O1	56458(Tax:10090)	56458(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Forkhead_box_O1 -LRB- FOXO1 -RRB- protein , but not p53 , contributes to robust induction of p21 expression in fasted mice .
25786691	0	FOXO1	0,5	ICAM-1	48,54	FOXO1	ICAM-1	56458(Tax:10090)	15894(Tax:10090)	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	FOXO1 Regulates Dendritic Cell Activity through ICAM-1 and CCR7 .
18713968	0	FOXO1	0,5	L-Selectin	16,26	FOXO1	L-Selectin	2308	6402	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase .
23133314	0	FOXO1	0,5	L-selectin	25,35	FOXO1	L-selectin	2308	6402	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FOXO1 Up-Regulates Human L-selectin Expression Through Binding to a Consensus FOXO1 Motif .
22848439	0	FOXO1	14,19	MKP-3	8,13	FOXO1	MKP-3	56458(Tax:10090)	67603(Tax:10090)	Gene	Gene	interaction|nsubj|START_ENTITY END_ENTITY|parataxis|interaction	Mapping MKP-3 / FOXO1 interaction and evaluating the effect on gluconeogenesis .
22569260	0	FOXO1	23,28	MicroRNA-223	0,12	FOXO1	MicroRNA-223	2308	407008	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-223 regulates FOXO1 expression and cell proliferation .
18211894	0	FOXO1	45,50	PP2A	0,4	FOXO1	PP2A	2308	5524	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PP2A regulates the pro-apoptotic activity of FOXO1 .
21505104	0	FOXO1	0,5	Runx2	15,20	FOXO1	Runx2	2308	860	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	FOXO1 inhibits Runx2 transcriptional activity and prostate_cancer cell migration and invasion .
15668399	0	FOXO1	14,19	Skp2	0,4	FOXO1	Skp2	56458(Tax:10090)	27401(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation .
25674226	0	FOXO1	61,66	TGF-b1	86,92	FOXO1	TGF-b1	56458(Tax:10090)	21803(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Dehydroabietic_acid reverses TNF-a-induced the activation of FOXO1 and suppression of TGF-b1 / Smad signaling in human adult dermal fibroblasts .
23803610	0	FOXO1	0,5	carbohydrate_response_element-binding_protein	20,65	FOXO1	carbohydrate response element-binding protein	2308	51085	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	FOXO1 competes with carbohydrate_response_element-binding_protein -LRB- ChREBP -RRB- and inhibits thioredoxin-interacting_protein -LRB- TXNIP -RRB- transcription in pancreatic beta cells .
20088826	0	FOXO1	43,48	cathepsin_L	4,15	FOXO1	cathepsin L	56458(Tax:10090)	13039(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	The cathepsin_L gene is a direct target of FOXO1 in skeletal muscle .
20033803	0	FOXO1	27,32	forkhead_box_O1	10,25	FOXO1	forkhead box O1	2308	2308	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of forkhead_box_O1 -LRB- FOXO1 -RRB- on beta cell development in the human fetal pancreas .
22223069	0	FOXO1	0,5	insulin	21,28	FOXO1	insulin	56458(Tax:10090)	3630	Gene	Gene	involvement|nummod|START_ENTITY involvement|nmod|END_ENTITY	FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes .
25676570	0	FOXO1	0,5	insulin	22,29	FOXO1	insulin	2308	3630	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes .
19574223	0	FOXO1	25,30	miR-27a	34,41	FOXO1	miR-27a	2308	407018	Gene	Gene	regulation|nmod|START_ENTITY Coordinate|dobj|regulation Coordinate|advcl|END_ENTITY	Coordinate regulation of FOXO1 by miR-27a , miR-96 , and miR-182 in breast_cancer cells .
25399953	0	FOXO1	111,116	miR-27a	103,110	FOXO1	miR-27a	84482(Tax:10116)	100314006(Tax:10116)	Gene	Gene	Axis|compound|START_ENTITY Axis|amod|END_ENTITY	Chitosan Degradation Products Promote Nerve Regeneration by Stimulating Schwann Cell Proliferation via miR-27a / FOXO1 Axis .
25897249	0	FOXO1	67,72	miR-27a	24,31	FOXO1	miR-27a	2308	407018	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Adipose tissue-secreted miR-27a promotes liver_cancer by targeting FOXO1 in obese individuals .
24260486	0	FOXO1	73,78	miR-96	30,36	FOXO1	miR-96	2308	407053	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	The antiapoptotic function of miR-96 in prostate_cancer by inhibition of FOXO1 .
25053419	0	FOXO1/3/4	116,125	I_insulin-like_growth_factor_receptor	39,76	FOXO1/3/4	I insulin-like growth factor receptor	2308;2309;4303	3480	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	GSK3 protein positively regulates type I_insulin-like_growth_factor_receptor through forkhead transcription factors FOXO1/3/4 .
12130586	0	FOXO1a	54,60	FKHR	48,52	FOXO1a	FKHR	2308	2308	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the forkhead transcription factor FKHR -LRB- FOXO1a -RRB- by glucose starvation and AICAR , an activator of AMP-activated protein kinase .
27043660	0	FOXO3	27,32	BRCA1	0,5	FOXO3	BRCA1	2309	672	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast_cancer .
27043660	0	FOXO3	59,64	BRCA1	0,5	FOXO3	BRCA1	2309	672	Gene	Gene	gene|compound|START_ENTITY silencing|nsubj|gene restricting|xcomp|silencing regulates|advcl|restricting regulates|nsubj|END_ENTITY	BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast_cancer .
26751098	0	FOXO3	89,94	Forkhead_box_O3	72,87	FOXO3	Forkhead box O3	101799850	101799850	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning , characterisation and functional analysis of the duck Forkhead_box_O3 -LRB- FOXO3 -RRB- gene .
26629010	0	FOXO3	18,23	MiR-592	0,7	FOXO3	MiR-592	2309	693177	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	MiR-592 represses FOXO3 expression and promotes the proliferation of prostate_cancer cells .
26505221	0	FOXO3	111,116	MicroRNA-223	0,12	FOXO3	MicroRNA-223	2309	407008	Gene	Gene	Upregulated|nmod|START_ENTITY Upregulated|nsubjpass|END_ENTITY	MicroRNA-223 Is Upregulated in Active Tuberculosis Patients and Inhibits Apoptosis of Macrophages by Targeting FOXO3 .
24947616	0	FOXO3	17,22	RRM2B	66,71	FOXO3	RRM2B	2309	50484	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients .
19494111	0	FOXO3	29,34	Runx1	0,5	FOXO3	Runx1	56484(Tax:10090)	12394(Tax:10090)	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta -LRB- TGFbeta -RRB- - induced Bim transcription in hepatic cells .
21841822	0	FOXO3	64,69	SIRT1	26,31	FOXO3	SIRT1	2309	23411	Gene	Gene	Skp2-mediated|dep|START_ENTITY ubiquitination|amod|Skp2-mediated leads|nmod|ubiquitination leads|nsubj|Deacetylation Deacetylation|nmod|FOXO3 FOXO3|nmod|END_ENTITY	Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation .
25158994	0	FOXO3	21,26	SIRT1	72,77	FOXO3	SIRT1	294515(Tax:10116)	309757(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts .
26816534	0	FOXO3	23,28	nm23-H1	68,75	FOXO3	nm23-H1	2309	4830	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Transcriptional factor FOXO3 negatively regulates the expression of nm23-H1 in non-small_cell_lung_cancer .
22893124	0	FOXO3	0,5	p53	34,37	FOXO3	p53	2309	7157	Gene	Gene	links|compound|START_ENTITY ATM|nsubj|links ATM|nmod|pathway pathway|compound|END_ENTITY	FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage .
25096914	0	FOXO3	76,81	p53	108,111	FOXO3	p53	2309	7157	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Auranofin displays anticancer activity against ovarian_cancer cells through FOXO3 activation independent of p53 .
24864229	0	FOXO3A	156,162	SGK1	98,102	FOXO3A	SGK1	2309	6446	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Diverse effects of ANXA7 and p53 on LNCaP prostate_cancer cells are associated with regulation of SGK1 transcription and phosphorylation of the SGK1 target FOXO3A .
18195003	0	FOXO3A	0,6	peroxiredoxin_III	17,34	FOXO3A	peroxiredoxin III	2309	10935	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	FOXO3A regulates peroxiredoxin_III expression in human cardiac fibroblasts .
15781459	0	FOXO3a	4,10	AKT	77,80	FOXO3a	AKT	56484(Tax:10090)	11651(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY regulates|nsubj|factor regulates|dobj|downstream downstream|nmod|signaling signaling|compound|END_ENTITY	The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling .
17079231	0	FOXO3a	77,83	Akt	87,90	FOXO3a	Akt	294515(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY dismutase|nmod|phosphorylation dismutase|nmod|END_ENTITY	Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats .
18385518	0	FOXO3a	86,92	Akt	154,157	FOXO3a	Akt	2309	207	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Endothelin-1 couples betaPix to p66Shc : role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt .
18644865	0	FOXO3a	34,40	Akt	77,80	FOXO3a	Akt	2309	207	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	The forkhead transcription factor FOXO3a increases phosphoinositide-3_kinase / Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression .
24337611	0	FOXO3a	83,89	Akt	109,112	FOXO3a	Akt	2309	207	Gene	Gene	activation|nmod|START_ENTITY inhibits|nmod|activation inhibits|nmod|inactivation inactivation|nmod|END_ENTITY	Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular_carcinoma .
26375988	0	FOXO3a	61,67	Akt	90,93	FOXO3a	Akt	2309	207	Gene	Gene	START_ENTITY|acl|translocation translocation|nmod|inhibition inhibition|compound|END_ENTITY	Methylseleninic_acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition .
18465250	0	FOXO3a	59,65	Bim	94,97	FOXO3a	Bim	294515(Tax:10116)	64547(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|transcription transcription|compound|END_ENTITY	p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription .
19302476	0	FOXO3a	74,80	CXCL12	0,6	FOXO3a	CXCL12	2309	6387	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	CXCL12 increases human neural progenitor cell proliferation through Akt-1 / FOXO3a signaling pathway .
17234971	0	FOXO3a	30,36	CYR61	96,101	FOXO3a	CYR61	294515(Tax:10116)	83476(Tax:10116)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61 , leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia .
18204439	0	FOXO3a	41,47	ERK	0,3	FOXO3a	ERK	56484(Tax:10090)	26413(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation .
21604264	0	FOXO3a	64,70	ERK	37,40	FOXO3a	ERK	2309	5594	Gene	Gene	translocation|amod|START_ENTITY decreased|nmod|translocation decreased|dobj|activities activities|compound|END_ENTITY	A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation .
18391984	0	FOXO3a	0,6	FLIP	53,57	FOXO3a	FLIP	2309	8837	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	FOXO3a mediates the androgen-dependent regulation of FLIP and contributes to TRAIL-induced apoptosis of LNCaP cells .
19276163	0	FOXO3a	50,56	FOXM1	29,34	FOXO3a	FOXM1	2309	2305	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Gefitinib -LRB- Iressa -RRB- represses FOXM1 expression via FOXO3a in breast_cancer .
24314213	0	FOXO3a	55,61	FOXM1	40,45	FOXO3a	FOXM1	2309	2305	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	-LSB- Effects of AG1478 on the expression of FOXM1 gene via FOXO3a in non-small cell lung_cancer cells -RSB- .
26344694	0	FOXO3a	72,78	Forkhead_box_K2	0,15	FOXO3a	Forkhead box K2	2309	3607	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Forkhead_box_K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast_cancer .
23761826	0	FOXO3a	93,99	FoxM1	61,66	FOXO3a	FoxM1	2309	2305	Gene	Gene	activation|nmod|START_ENTITY repressing|nmod|activation repressing|dobj|END_ENTITY	Casticin induces ovarian_cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a .
26470790	0	FOXO3a	34,40	GPER	84,88	FOXO3a	GPER	2309	2852	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Estrogen-mediated inactivation of FOXO3a by the G_protein-coupled_estrogen_receptor GPER .
23691078	0	FOXO3a	40,46	IKBKE	0,5	FOXO3a	IKBKE	2309	9641	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	IKBKE phosphorylation and inhibition of FOXO3a : a mechanism of IKBKE oncogenic function .
23691078	0	FOXO3a	40,46	IKBKE	63,68	FOXO3a	IKBKE	2309	9641	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|dep|mechanism mechanism|nmod|function function|amod|END_ENTITY	IKBKE phosphorylation and inhibition of FOXO3a : a mechanism of IKBKE oncogenic function .
19608644	0	FOXO3a	21,27	Insulin	0,7	FOXO3a	Insulin	2309	3630	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1 .
21604264	0	FOXO3a	64,70	JNK	15,18	FOXO3a	JNK	2309	5599	Gene	Gene	translocation|amod|START_ENTITY decreased|nmod|translocation decreased|nsubj|pathway pathway|nmod|END_ENTITY	A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation .
22297293	0	FOXO3a	14,20	JNK	0,3	FOXO3a	JNK	294515(Tax:10116)	116554(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart_failure .
20371610	0	FOXO3a	80,86	MicroRNA-155	0,12	FOXO3a	MicroRNA-155	2309	406947	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-155 regulates cell survival , growth , and chemosensitivity by targeting FOXO3a in breast_cancer .
19427386	0	FOXO3a	57,63	P53	0,3	FOXO3a	P53	2309	7157	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	P53 negatively regulates the transcriptional activity of FOXO3a under oxidative stress .
25640014	0	FOXO3a	101,107	SIRT1	0,5	FOXO3a	SIRT1	2309	23411	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	SIRT1 protects against oxidative stress-induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation .
18781224	0	FOXO3a	40,46	SIRT3	0,5	FOXO3a	SIRT3	2309	23410	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria , as well as increases FOXO3a dependent gene expression .
21294163	0	FOXO3a	0,6	TNF-a	16,21	FOXO3a	TNF-a	56484(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|amod|END_ENTITY	FOXO3a inhibits TNF-a - and IL-1b-induced astrocyte proliferation : Implication for reactive astrogliosis .
21860419	0	FOXO3a	0,6	VEGF	17,21	FOXO3a	VEGF	2309	7422	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	FOXO3a represses VEGF expression through FOXM1-dependent and - independent mechanisms in breast_cancer .
25578861	0	FOXO3a	0,6	WNT/b-catenin	17,30	FOXO3a	WNT/b-catenin	2309	1499	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|signaling signaling|amod|END_ENTITY	FOXO3a modulates WNT/b-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate_cancer cells .
19355923	0	FOXO3a	34,40	caspase_3	123,132	FOXO3a	caspase 3	2309	836	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic_injury through caspase_3 .
15367686	0	FOXO3a	34,40	estrogen_receptor_alpha	51,74	FOXO3a	estrogen receptor alpha	2309	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Forkhead box transcription factor FOXO3a regulates estrogen_receptor_alpha expression and is repressed by the Her-2 / neu/phosphatidylinositol _ 3-kinase/Akt signaling pathway .
17575143	0	FOXO3a	14,20	estrogen_receptor_alpha	84,107	FOXO3a	estrogen receptor alpha	2309	2099	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|dobj|expression expression|compound|END_ENTITY	Activation of FOXO3a by the green tea polyphenol_epigallocatechin-3-gallate induces estrogen_receptor_alpha expression reversing invasive phenotype of breast_cancer cells .
23970205	0	FOXO3a	68,74	microRNA-155	0,12	FOXO3a	microRNA-155	2309	406947	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	microRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma .
18824006	0	FOXO3a	80,86	p53	108,111	FOXO3a	p53	2309	7157	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53 .
19473970	0	FOXO3a	0,6	tumor_necrosis_factor_receptor_2	49,81	FOXO3a	tumor necrosis factor receptor 2	2309	7133	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	FOXO3a regulates oxygen-responsive expression of tumor_necrosis_factor_receptor_2 in human dermal microvascular endothelial cells .
19285077	0	FOXO3a	95,101	tyrosine_hydroxylase	16,36	FOXO3a	tyrosine hydroxylase	2309	7054	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	SIRT1 regulates tyrosine_hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a .
15688030	0	FOXO4	22,27	Akt	37,40	FOXO4	Akt	4303	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Constitutively active FOXO4 inhibits Akt activity , regulates p27_Kip1 stability , and suppresses HER2-mediated tumorigenicity .
20136501	0	FOXO4	0,5	plasminogen_activator_inhibitor-1	20,53	FOXO4	plasminogen activator inhibitor-1	4303	5054	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	FOXO4 induces human plasminogen_activator_inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels .
24232982	0	FOXP1	62,67	miR-34a	27,34	FOXP1	miR-34a	27086	407040	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of miR-34a and its target proteins of FOXP1 , p53 , and BCL2 in gastric_MALT_lymphoma and DLBCL .
21927029	0	FOXP1	104,109	miR-504	96,103	FOXP1	miR-504	27086	574507	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Connective_tissue_growth_factor modulates oral_squamous_cell_carcinoma invasion by activating a miR-504 / FOXP1 signalling .
18079162	0	FOXP2	53,58	FoxP2	11,16	FOXP2	FoxP2	93986	100169841(Tax:8090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The medaka FoxP2 , a homologue of human language gene FOXP2 , has a diverged structure and function .
22504457	0	FOXP2	66,71	forkhead_box_P2	49,64	FOXP2	forkhead box P2	93986	93986	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An association study of sequence variants in the forkhead_box_P2 -LRB- FOXP2 -RRB- gene and adulthood attention-deficit/hyperactivity _ disorder in two European samples .
25053455	0	FOXP3	75,80	B7-H1_and_B7-H4	0,15	FOXP3	B7-H1 and B7-H4	50943	29126;79679	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|amod|END_ENTITY	B7-H1_and_B7-H4 expression in colorectal_carcinoma : correlation with tumor FOXP3 -LRB- + -RRB- regulatory T-cell infiltration .
22319577	0	FOXP3	30,35	CCR4	16,20	FOXP3	CCR4	50943	1233	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Accumulation of CCR4 CTLA-4 FOXP3 CD25 -LRB- hi -RRB- regulatory T cells in colon_adenocarcinomas correlate to reduced activation of conventional T cells .
22821963	0	FOXP3	16,21	CCR7	11,15	FOXP3	CCR7	50943	1236	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD45RA + CCR7 + FOXP3 + T cells with immunosuppressive properties : a novel subset of inducible human regulatory T cells .
20690182	0	FOXP3	40,45	CD127	10,15	FOXP3	CD127	50943	3575	Gene	Gene	CD4|compound|START_ENTITY expression|nmod|CD4 expression|compound|END_ENTITY	Increased CD127 expression on activated FOXP3 + CD4 + regulatory T cells .
21799858	0	FOXP3	113,118	CD127	100,105	FOXP3	CD127	50943	3575	Gene	Gene	cells|compound|START_ENTITY generated|nsubj|cells +|parataxis|generated +|nmod|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
23019018	0	FOXP3	56,61	CD127	9,14	FOXP3	CD127	50943	3575	Gene	Gene	cells|nummod|START_ENTITY phenotype|nmod|cells assessment|nmod|phenotype END_ENTITY|dep|assessment	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
15466453	0	FOXP3	16,21	CD25	63,67	FOXP3	CD25	50943	3559	Gene	Gene	role|nmod|START_ENTITY role|nmod|development development|nmod|cells cells|compound|END_ENTITY	Crucial role of FOXP3 in the development and function of human CD25 + CD4 + regulatory T cells .
15620457	0	FOXP3	14,19	CD25	48,52	FOXP3	CD25	50943	3669	Gene	Gene	mRNA|compound|START_ENTITY Expression|nmod|mRNA confined|nsubjpass|Expression confined|nmod|cells cells|compound|END_ENTITY	Expression of FOXP3 mRNA is not confined to CD4 + CD25 + T regulatory cells in humans .
15902688	0	FOXP3	12,17	CD25	50,54	FOXP3	CD25	50943	3559	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Analysis of FOXP3 protein expression in human CD4 + CD25 + regulatory T cells at the single-cell level .
16339542	0	FOXP3	109,114	CD25	122,126	FOXP3	CD25	50943	3559	Gene	Gene	capacity|nmod|START_ENTITY enhances|dobj|capacity enhances|nmod|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16645171	0	FOXP3	15,20	CD25	45,49	FOXP3	CD25	50943	3559	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16785520	0	FOXP3	0,5	CD25	10,14	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	FOXP3 + CD4 + CD25 + adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin_E2-dependent mechanism .
17142730	0	FOXP3	52,57	CD25	47,51	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients .
17258077	0	FOXP3	31,36	CD25	51,55	FOXP3	CD25	50943	3559	Gene	Gene	CD4|compound|START_ENTITY generation|nmod|CD4 IL-2-independent|dobj|generation IL-2-independent|dep|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17296785	0	FOXP3	68,73	CD25	61,65	FOXP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	WASP regulates suppressor activity of human and murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- natural regulatory T cells .
17463169	0	FOXP3	21,26	CD25	15,19	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic_anemia .
17478450	0	FOXP3	58,63	CD25	80,84	FOXP3	CD25	50943	3559	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses .
17582431	0	FOXP3	70,75	CD25	65,69	FOXP3	CD25	50943	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flow cytometry-based methods for studying signaling in human CD4 + CD25 + FOXP3 + T regulatory cells .
17916446	0	FOXP3	109,114	CD25	46,50	FOXP3	CD25	50943	3559	Gene	Gene	mutations|compound|START_ENTITY patients|nmod|mutations +|nmod|patients +|nsubj|changes changes|nmod|END_ENTITY	Developmental changes of FOXP3-expressing CD4 + CD25 + regulatory T cells and their impairment in patients with FOXP3 gene mutations .
18025205	0	FOXP3	26,31	CD25	21,25	FOXP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18180044	0	FOXP3	18,23	CD25	59,63	FOXP3	CD25	50943	3559	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Cloning of feline FOXP3 and detection of expression in CD4 + CD25 + regulatory T cells .
18266270	0	FOXP3	55,60	CD25	48,52	FOXP3	CD25	50943	3559	Gene	Gene	START_ENTITY|nsubj|Generation Generation|nmod|END_ENTITY	Generation of highly suppressive adaptive CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells by continuous antigen stimulation .
18270368	0	FOXP3	53,58	CD25	66,70	FOXP3	CD25	50943	3559	Gene	Gene	expression|nmod|START_ENTITY regulate|dobj|expression regulate|nmod|END_ENTITY	STAT5-signaling cytokines regulate the expression of FOXP3 in CD4 + CD25 + regulatory T cells and CD4 + CD25 - effector T cells .
18287134	0	FOXP3	9,14	CD25	4,8	FOXP3	CD25	50943	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + FOXP3 + T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple_myeloma following allogeneic stem cell transplantation .
18295349	0	FOXP3	84,89	CD25	79,83	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Matured human monocyte-derived dendritic cells -LRB- MoDCs -RRB- induce expansion of CD4 + CD25 + FOXP3 + T cells lacking regulatory properties .
18308639	0	FOXP3	79,84	CD25	74,78	FOXP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGFbeta1_deficiency does not affect the generation and maintenance of CD4 + CD25 + FOXP3 + putative Treg cells , but causes their numerical inadequacy and loss of regulatory function .
18360256	0	FOXP3	46,51	CD25	41,45	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Impact of immunosuppressive drugs on CD4 + CD25 + FOXP3 + regulatory T cells : does in vitro evidence translate to the clinical setting ?
18368594	0	FOXP3	68,73	CD25	62,66	FOXP3	CD25	50943	3559	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Regulatory T-cell depletion does not prevent emergence of new CD25 + FOXP3 + lymphocytes after antigen stimulation in culture .
18493981	0	FOXP3	66,71	CD25	40,44	FOXP3	CD25	50943	3559	Gene	Gene	expressing|dobj|START_ENTITY expressing|nsubj|inducer inducer|nmod|cells cells|amod|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
18497513	0	FOXP3	18,23	CD25	86,90	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY Cells|nummod|+ +|dobj|Cells +|nmod|conversion conversion|nmod|END_ENTITY	Increased CD4CD25 + FOXP3 + regulatory T Cells in cancer patients from conversion of CD4 + CD25 - T cells through tumor-derived factors .
18508492	0	FOXP3	24,29	CD25	13,17	FOXP3	CD25	50943	3559	Gene	Gene	Tregs|compound|START_ENTITY END_ENTITY|dep|Tregs	Roles of CD4 + CD25 -LRB- high -RRB- FOXP3 + Tregs in lymphomas and tumors are complex .
18606654	0	FOXP3	0,5	CD25	47,51	FOXP3	CD25	50943	3559	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phenotype phenotype|compound|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
18606654	0	FOXP3	0,5	CD25	87,91	FOXP3	CD25	50943	3559	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phenotype phenotype|nmod|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
19303058	0	FOXP3	76,81	CD25	100,104	FOXP3	CD25	50943	3559	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Correlation between the degree of immune activation , production of IL-2 and FOXP3 expression in CD4 + CD25 + T regulatory cells in HIV-1 infected persons under HAART .
19309551	0	FOXP3	6,11	CD25	12,16	FOXP3	CD25	50943	3559	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	CXCR4 + FOXP3 + CD25 + lymphocytes accumulate in CXCL12-expressing malignant_pleural_mesothelioma .
19646767	0	FOXP3	90,95	CD25	83,87	FOXP3	CD25	50943	3559	Gene	Gene	function|nsubj|START_ENTITY function|nmod|expansion expansion|nmod|END_ENTITY	Glatiramer_acetate improves regulatory T-cell function by expansion of naive CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- CD31 -LRB- + -RRB- T-cells in patients with multiple_sclerosis .
19738030	0	FOXP3	10,15	CD25	45,49	FOXP3	CD25	50943	3669	Gene	Gene	cells|nsubj|START_ENTITY cells|amod|active active|nmod|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19738030	0	FOXP3	113,118	CD25	45,49	FOXP3	CD25	50943	3669	Gene	Gene	mutations|compound|START_ENTITY carriers|nmod|mutations cells|nmod|carriers cells|amod|active active|nmod|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19752528	0	FOXP3	28,33	CD25	16,20	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Circulating CD4 + CD25 bright FOXP3 + T cells are up-regulated by biological therapies and correlate with the clinical response in psoriasis patients .
20498045	0	FOXP3	50,55	CD25	45,49	FOXP3	CD25	50943	3559	Gene	Gene	+|nsubj|START_ENTITY +|nmod|expansion expansion|nmod|END_ENTITY	In vivo expansion of naive and activated CD4 + CD25 + FOXP3 + regulatory T cell populations in interleukin-2-treated HIV patients .
20854875	0	FOXP3	31,36	CD25	25,29	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY increased|nsubjpass|cells increased|dep|occurring occurring|dobj|+ +|compound|END_ENTITY	Naturally occurring CD4 + CD25 + FOXP3 + T-regulatory cells are increased in chronic_myeloid_leukemia patients not in complete cytogenetic remission and can be immunosuppressive .
20858449	0	FOXP3	41,46	CD25	36,40	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating regulatory T cells -LRB- CD4 + CD25 + FOXP3 + -RRB- decrease in breast_cancer patients after vaccination with a modified MHC class II HER2/neu -LRB- AE37 -RRB- peptide .
21107346	0	FOXP3	50,55	CD25	43,47	FOXP3	CD25	50943	3559	Gene	Gene	START_ENTITY|nsubj|Mechanisms Mechanisms|nmod|regulation regulation|nmod|END_ENTITY	Mechanisms of impaired regulation by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in human autoimmune_diseases .
21437244	0	FOXP3	63,68	CD25	57,61	FOXP3	CD25	50943	3669	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracerebral human regulatory T cells : analysis of CD4 + CD25 + FOXP3 + T cells in brain_lesions and cerebrospinal fluid of multiple_sclerosis patients .
21691076	0	FOXP3	139,144	CD25	117,121	FOXP3	CD25	50943	3559	Gene	Gene	Forkhead_Boxp3|appos|START_ENTITY Forkhead_Boxp3|compound|END_ENTITY	Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute_lung_injury by expanding CD4 + CD25 + Forkhead_Boxp3 -LRB- FOXP3 -RRB- + regulatory T cells and balancing anti- and pro-inflammatory factors .
21799858	0	FOXP3	113,118	CD25	107,111	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21829534	0	FOXP3	129,134	CD25	123,127	FOXP3	CD25	50943	3559	Gene	Gene	compartment|compound|START_ENTITY compartment|compound|END_ENTITY	NY-ESO-1-specific circulating CD4 + T cells in ovarian_cancer patients are prevalently T -LRB- H -RRB- 1 type cells undetectable in the CD25 + FOXP3 + Treg compartment .
22276195	0	FOXP3	44,49	CD25	33,37	FOXP3	CD25	50943	3559	Gene	Gene	+|nsubj|START_ENTITY +|nmod|expansion expansion|nmod|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22891772	0	FOXP3	90,95	CD25	53,57	FOXP3	CD25	50943	3559	Gene	Gene	T|nsubj|START_ENTITY T|dep|modulates modulates|dobj|conversion conversion|nmod|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22891772	0	FOXP3	90,95	CD25	80,84	FOXP3	CD25	50943	3559	Gene	Gene	T|nsubj|START_ENTITY T|nmod|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
23019018	0	FOXP3	56,61	CD25	4,8	FOXP3	CD25	50943	3559	Gene	Gene	cells|nummod|START_ENTITY phenotype|nmod|cells assessment|nmod|phenotype CD127|dep|assessment CD127|compound|END_ENTITY	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
23144749	0	FOXP3	30,35	CD25	48,52	FOXP3	CD25	50943	3559	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-kB .
23340699	0	FOXP3	21,26	CD25	14,18	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lack of CD4 CD25 FOXP3 regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki_disease .
23509755	0	FOXP3	11,16	CD25	5,9	FOXP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + FOXP3 + Treg cells induced by rSSP4 derived from T. _ cruzi amastigotes increase parasitemia in an experimental Chagas_disease model .
23968847	0	FOXP3	56,61	CD25	50,54	FOXP3	CD25	50943	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Influences of cerebral stent implantation on CD4 + CD25 + FOXP3 + Treg , Th1 and Th17 cells .
23993302	0	FOXP3	23,28	CD25	89,93	FOXP3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY depletion|nmod|cells occurs|nsubj|depletion occurs|nmod|END_ENTITY	Selective depletion of FOXP3 -LRB- high -RRB- cells by Fas-Fas-L-induced apoptosis occurs in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - enriched populations during repeated expansion .
24076591	0	FOXP3	57,62	CD25	52,56	FOXP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Arteether exerts antitumor activity and reduces CD4 + CD25 + FOXP3 + T-reg cells in vivo .
24244610	0	FOXP3	40,45	CD25	34,38	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24345703	0	FOXP3	20,25	CD25	15,19	FOXP3	CD25	50943	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes of CD4 + CD25 + FOXP3 + and CD8 + CD28 - regulatory T cells in non-small_cell_lung_cancer patients undergoing surgery .
24368924	0	FOXP3	43,48	CD25	38,42	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An imbalance between frequency of CD4 + CD25 + FOXP3 + regulatory T cells and CCR4 + and CCR9 + circulating helper T cells is associated with active perennial allergic_conjunctivitis .
24454972	0	FOXP3	42,47	CD25	34,38	FOXP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
25205084	0	FOXP3	42,47	CD25	32,36	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY cells|dep|+ cells|dep|influence influence|nmod|therapy therapy|nmod|END_ENTITY	The influence of therapy on CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in systemic_lupus_erythematosus patients : a prospective study .
25485946	0	FOXP3	24,29	CD25	96,100	FOXP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY +|nsubj|CD4 +|nmod|Expression Expression|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
25655390	0	FOXP3	17,22	CD25	8,12	FOXP3	CD25	50943	3559	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	CD4 -LRB- + -RRB- , CD25 -LRB- + -RRB- , FOXP3 -LRB- + -RRB- T Regulatory Cell Levels in Obese , Asthmatic , Asthmatic_Obese , and Healthy Children .
25672298	0	FOXP3	36,41	CD25	31,35	FOXP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	T regulatory cells -LRB- TREG -RRB- -LRB- TCD4 + CD25 + FOXP3 + -RRB- distribution in the different clinical forms of leprosy and reactional states .
25950023	0	FOXP3	136,141	CD25	131,135	FOXP3	CD25	491876(Tax:9615)	403870(Tax:9615)	Gene	Gene	CELLS|compound|START_ENTITY CELLS|compound|END_ENTITY	EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4 + CD25 + FOXP3 + REGULATORY T CELLS .
26166019	0	FOXP3	45,50	CD25	40,44	FOXP3	CD25	50943	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26287664	0	FOXP3	53,58	CD25	42,46	FOXP3	CD25	50943	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Correlation of TSLP , IL-33 , and CD4 + CD25 + FOXP3 + T regulatory -LRB- Treg -RRB- in pediatric asthma .
26467610	0	FOXP3	56,61	CD25	90,94	FOXP3	CD25	50943	3669	Gene	Gene	Treg|compound|START_ENTITY expression|nmod|Treg usage|appos|expression subsets|nsubj|usage subsets|nmod|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
20631311	0	FOXP3	49,54	CD30	0,4	FOXP3	CD30	50943	943	Gene	Gene	cells|compound|START_ENTITY heat_shock|dobj|cells heat_shock|nsubj|discriminates discriminates|compound|END_ENTITY	CD30 discriminates heat_shock protein 60-induced FOXP3 + CD4 + T cells with a regulatory phenotype .
19957514	0	FOXP3	15,20	CD39	29,33	FOXP3	CD39	50943	953	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	-LSB- Expression of FOXP3 in CD4 + CD39 + T cells of patients with systemic_lupus_erythematosus and dynamic observation of treatment with glucocorticoid -RSB- .
22585562	0	FOXP3	56,61	CD39	50,54	FOXP3	CD39	50943	953	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
26467610	0	FOXP3	56,61	CD39	135,139	FOXP3	CD39	50943	953	Gene	Gene	Treg|compound|START_ENTITY expression|nmod|Treg usage|appos|expression subsets|nsubj|usage subsets|dobj|cells cells|acl|identified identified|nmod|expression expression|nmod|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
15466453	0	FOXP3	16,21	CD4	68,71	FOXP3	CD4	50943	920	Gene	Gene	role|nmod|START_ENTITY role|nmod|development development|nmod|cells cells|compound|END_ENTITY	Crucial role of FOXP3 in the development and function of human CD25 + CD4 + regulatory T cells .
15620457	0	FOXP3	14,19	CD4	44,47	FOXP3	CD4	50943	920	Gene	Gene	mRNA|compound|START_ENTITY Expression|nmod|mRNA confined|nsubjpass|Expression confined|nmod|cells cells|compound|END_ENTITY	Expression of FOXP3 mRNA is not confined to CD4 + CD25 + T regulatory cells in humans .
15902688	0	FOXP3	12,17	CD4	46,49	FOXP3	CD4	50943	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|CD25 CD25|compound|END_ENTITY	Analysis of FOXP3 protein expression in human CD4 + CD25 + regulatory T cells at the single-cell level .
15972448	0	FOXP3	21,26	CD4	28,31	FOXP3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Reduced frequency of FOXP3 + CD4 + CD25 + regulatory T cells in patients with chronic_graft-versus-host_disease .
16211090	0	FOXP3	14,19	CD4	56,59	FOXP3	CD4	50943	920	Gene	Gene	role|nmod|START_ENTITY isoforms|nsubj|role isoforms|nmod|generation generation|nmod|Tregs Tregs|compound|END_ENTITY	The role of 2 FOXP3 isoforms in the generation of human CD4 + Tregs .
16339542	0	FOXP3	109,114	CD4	118,121	FOXP3	CD4	50943	920	Gene	Gene	capacity|nmod|START_ENTITY enhances|dobj|capacity enhances|nmod|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16339542	0	FOXP3	109,114	CD4	6,9	FOXP3	CD4	50943	920	Gene	Gene	capacity|nmod|START_ENTITY enhances|dobj|capacity express|ccomp|enhances express|nsubj|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16585024	0	FOXP3	54,59	CD4	63,66	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Expression of the putatively regulatory T-cell marker FOXP3 by CD4 -LRB- + -RRB- CD25 + T cells after pediatric hematopoietic stem cell transplantation .
16645171	0	FOXP3	15,20	CD4	41,44	FOXP3	CD4	50943	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16764698	0	FOXP3	0,5	CD4	39,42	FOXP3	CD4	50943	920	Gene	Gene	identifies|nsubj|START_ENTITY identifies|dobj|cells cells|compound|END_ENTITY	FOXP3 identifies regulatory CD25bright CD4 + T cells in rheumatic_joints .
16785520	0	FOXP3	0,5	CD4	6,9	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	FOXP3 + CD4 + CD25 + adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin_E2-dependent mechanism .
17005002	0	FOXP3	25,30	CD4	66,69	FOXP3	CD4	50943	920	Gene	Gene	variants|nmod|START_ENTITY functional|nsubj|variants functional|dobj|inhibitors inhibitors|nmod|activation activation|compound|END_ENTITY	Splice variants of human FOXP3 are functional inhibitors of human CD4 + T-cell activation .
17082609	0	FOXP3	59,64	CD4	27,30	FOXP3	CD4	50943	920	Gene	Gene	regulatory|compound|START_ENTITY enriched|nmod|regulatory cells|acl|enriched cells|nummod|END_ENTITY	CCR8 expression identifies CD4 memory T cells enriched for FOXP3 + regulatory and Th2 effector lymphocytes .
17142730	0	FOXP3	52,57	CD4	43,46	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin promotes expansion of functional CD4 + CD25 + FOXP3 + regulatory T cells of both healthy subjects and type 1 diabetic patients .
17154262	0	FOXP3	24,29	CD4	63,66	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Transient expression of FOXP3 in human activated nonregulatory CD4 + T cells .
17178393	0	FOXP3	61,66	CD4	56,59	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 blockade promotes the expansion of antigen-specific CD4 + FOXP3 + regulatory T cells in vivo .
17198560	0	FOXP3	13,18	CD4	27,30	FOXP3	CD4	50943	920	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|cells cells|compound|END_ENTITY	-LSB- Decrease of FOXP3 mRNA in CD4 + T cells in latent_autoimmune_diabetes_in_adult -RSB- .
17296785	0	FOXP3	68,73	CD4	55,58	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|dep|START_ENTITY activity|nmod|CD25 CD25|compound|END_ENTITY	WASP regulates suppressor activity of human and murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- natural regulatory T cells .
17463169	0	FOXP3	21,26	CD4	10,13	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Deficient CD4 + CD25 + FOXP3 + T regulatory cells in acquired aplastic_anemia .
17478450	0	FOXP3	58,63	CD4	76,79	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses .
17582431	0	FOXP3	70,75	CD4	61,64	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flow cytometry-based methods for studying signaling in human CD4 + CD25 + FOXP3 + T regulatory cells .
17644734	0	FOXP3	13,18	CD4	45,48	FOXP3	CD4	50943	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Induction of FOXP3 expression in naive human CD4 + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype .
17644734	0	FOXP3	49,54	CD4	45,48	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction of FOXP3 expression in naive human CD4 + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype .
17671219	0	FOXP3	44,49	CD4	40,43	FOXP3	CD4	50943	920	Gene	Gene	pool|compound|START_ENTITY pool|compound|END_ENTITY	Interleukin-2 administration alters the CD4 + FOXP3 + T-cell pool and tumor trafficking in patients with ovarian_carcinoma .
17916446	0	FOXP3	109,114	CD4	42,45	FOXP3	CD4	50943	920	Gene	Gene	mutations|compound|START_ENTITY patients|nmod|mutations +|nmod|patients +|nsubj|changes changes|nmod|CD25 CD25|compound|END_ENTITY	Developmental changes of FOXP3-expressing CD4 + CD25 + regulatory T cells and their impairment in patients with FOXP3 gene mutations .
17982112	0	FOXP3	0,5	CD4	25,28	FOXP3	CD4	50943	920	Gene	Gene	expressing|compound|START_ENTITY cells|nummod|expressing cells|compound|END_ENTITY	FOXP3 expressing CD127lo CD4 + T cells inversely correlate with CD38 + CD8 + T cell activation levels in primary HIV-1_infection .
17984976	0	FOXP3	102,107	CD4	38,41	FOXP3	CD4	50943	920	Gene	Gene	expression|nmod|START_ENTITY T|nmod|expression T|nsubj|Generation Generation|nmod|+ +|compound|END_ENTITY	Generation of potent and stable human CD4 + T regulatory cells by activation-independent expression of FOXP3 .
18025205	0	FOXP3	26,31	CD4	17,20	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18173798	0	FOXP3	25,30	CD4	20,23	FOXP3	CD4	50943	920	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Characterization of CD4 + FOXP3 + T-cell clones established from chronic inflammatory lesions .
18180044	0	FOXP3	18,23	CD4	55,58	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|CD25 CD25|compound|END_ENTITY	Cloning of feline FOXP3 and detection of expression in CD4 + CD25 + regulatory T cells .
18270250	0	FOXP3	52,57	CD4	25,28	FOXP3	CD4	50943	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Differentiation of naive CD4 + T cells into CD4 + CD25 + FOXP3 + regulatory T cells by continuous antigen stimulation .
18270368	0	FOXP3	53,58	CD4	62,65	FOXP3	CD4	50943	920	Gene	Gene	expression|nmod|START_ENTITY regulate|dobj|expression regulate|nmod|CD25 CD25|compound|END_ENTITY	STAT5-signaling cytokines regulate the expression of FOXP3 in CD4 + CD25 + regulatory T cells and CD4 + CD25 - effector T cells .
18287134	0	FOXP3	9,14	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + FOXP3 + T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple_myeloma following allogeneic stem cell transplantation .
18295349	0	FOXP3	84,89	CD4	75,78	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Matured human monocyte-derived dendritic cells -LRB- MoDCs -RRB- induce expansion of CD4 + CD25 + FOXP3 + T cells lacking regulatory properties .
18308639	0	FOXP3	79,84	CD4	70,73	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TGFbeta1_deficiency does not affect the generation and maintenance of CD4 + CD25 + FOXP3 + putative Treg cells , but causes their numerical inadequacy and loss of regulatory function .
18313267	0	FOXP3	84,89	CD4	71,74	FOXP3	CD4	50943	920	Gene	Gene	T|compound|START_ENTITY induction|dep|T induction|nmod|CD25 CD25|compound|END_ENTITY	Combination of rapamycin and IL-2 increases de novo induction of human CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cells .
18331536	0	FOXP3	76,81	CD4	25,28	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY circulating|nmod|cells circulating|dobj|cells cells|nummod|END_ENTITY	Decreases in circulating CD4 + CD25hiFOXP3 + cells and increases in intragraft FOXP3 + cells accompany allograft rejection in pediatric liver allograft recipients .
18360256	0	FOXP3	46,51	CD4	37,40	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|dep|Impact Impact|nmod|drugs drugs|nmod|+ +|compound|END_ENTITY	Impact of immunosuppressive drugs on CD4 + CD25 + FOXP3 + regulatory T cells : does in vitro evidence translate to the clinical setting ?
18481388	0	FOXP3	27,32	CD4	34,37	FOXP3	CD4	50943	920	Gene	Gene	reduction|nmod|START_ENTITY +|nsubj|reduction +|dobj|cells cells|compound|END_ENTITY	Partial reduction of human FOXP3 + CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration .
18489537	0	FOXP3	116,121	CD4	38,41	FOXP3	CD4	50943	920	Gene	Gene	mutation|compound|START_ENTITY T|nmod|mutation T|nsubj|depletion depletion|nmod|+ +|compound|END_ENTITY	A remarkable depletion of both na ve CD4 + and CD8 + with high proportion of memory T cells in an IPEX infant with a FOXP3 mutation in the forkhead domain .
18493981	0	FOXP3	66,71	CD4	34,37	FOXP3	CD4	50943	920	Gene	Gene	expressing|dobj|START_ENTITY expressing|nsubj|inducer inducer|nmod|cells cells|amod|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
18497513	0	FOXP3	18,23	CD4	82,85	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY Cells|nummod|+ +|dobj|Cells +|nmod|conversion conversion|nmod|CD25 CD25|compound|END_ENTITY	Increased CD4CD25 + FOXP3 + regulatory T Cells in cancer patients from conversion of CD4 + CD25 - T cells through tumor-derived factors .
18504453	0	FOXP3	4,9	CD4	27,30	FOXP3	CD4	50943	920	Gene	Gene	subset|compound|START_ENTITY subset|nmod|thymocytes thymocytes|compound|END_ENTITY	The FOXP3 + subset of human CD4 + CD8 + thymocytes is immature and subject to intrathymic selection .
18508492	0	FOXP3	24,29	CD4	9,12	FOXP3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY CD25|dep|Tregs CD25|compound|END_ENTITY	Roles of CD4 + CD25 -LRB- high -RRB- FOXP3 + Tregs in lymphomas and tumors are complex .
18606654	0	FOXP3	0,5	CD4	83,86	FOXP3	CD4	50943	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phenotype phenotype|nmod|CD25 CD25|compound|END_ENTITY	FOXP3 induced by CD28/B7 interaction regulates CD25 and anergic phenotype in human CD4 + CD25 - T lymphocytes .
18829063	0	FOXP3	0,5	CD4	34,37	FOXP3	CD4	50943	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|HIV-1_infection HIV-1_infection|nmod|T-cells T-cells|compound|END_ENTITY	FOXP3 inhibits HIV-1_infection of CD4 T-cells via inhibition of LTR transcriptional activity .
18981158	0	FOXP3	79,84	CD4	74,77	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The effector T cells of diabetic subjects are resistant to regulation via CD4 + FOXP3 + regulatory T cells .
19089812	0	FOXP3	41,46	CD4	36,39	FOXP3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	High frequency and proliferation of CD4 + FOXP3 + Treg in HIV-1-infected patients with low CD4 counts .
19089812	0	FOXP3	41,46	CD4	89,92	FOXP3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|nmod|patients patients|nmod|END_ENTITY	High frequency and proliferation of CD4 + FOXP3 + Treg in HIV-1-infected patients with low CD4 counts .
19203731	0	FOXP3	77,82	CD4	9,12	FOXP3	CD4	50943	920	Gene	Gene	cells|nummod|START_ENTITY expand|dobj|cells expand|nsubj|infusion infusion|compound|END_ENTITY	Combined CD4 + donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3 + regulatory T cells following allogeneic hematopoietic stem cell transplantation .
19283780	0	FOXP3	8,13	CD4	42,45	FOXP3	CD4	50943	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|CD25 CD25|compound|END_ENTITY	Loss of FOXP3 expression in natural human CD4 + CD25 + regulatory T cells upon repetitive in vitro stimulation .
19303058	0	FOXP3	76,81	CD4	96,99	FOXP3	CD4	50943	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Correlation between the degree of immune activation , production of IL-2 and FOXP3 expression in CD4 + CD25 + T regulatory cells in HIV-1 infected persons under HAART .
19352129	0	FOXP3	130,135	CD4	126,129	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Conversion from calcineurin_inhibitor to mycophenolate_mofetil-based immunosuppression changes the frequency and phenotype of CD4 + FOXP3 + regulatory T cells .
19394278	0	FOXP3	37,42	CD4	21,24	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|amod|Reduced Reduced|dep|frequency frequency|nmod|CD25 CD25|compound|END_ENTITY	Reduced frequency of CD4 -LRB- + -RRB- CD25 -LRB- HIGH -RRB- FOXP3 -LRB- + -RRB- cells and diminished FOXP3 expression in patients with Common_Variable_Immunodeficiency : a link to autoimmunity ?
19596013	0	FOXP3	0,5	CD4	47,50	FOXP3	CD4	50943	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	FOXP3 expression in hepatitis_C virus-specific CD4 + T cells during acute_hepatitis_C .
19646767	0	FOXP3	90,95	CD4	77,80	FOXP3	CD4	50943	920	Gene	Gene	function|nsubj|START_ENTITY function|nmod|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	Glatiramer_acetate improves regulatory T-cell function by expansion of naive CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- CD31 -LRB- + -RRB- T-cells in patients with multiple_sclerosis .
19713458	0	FOXP3	4,9	CD4	0,3	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FOXP3 + regulatory T cells confer long-term regulation of factor_VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice .
19727527	0	FOXP3	76,81	CD4	63,66	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY amplifies|nmod|cells amplifies|dobj|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	A glucocorticoid amplifies IL-2-induced selective expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft-versus-host_disease after allogeneic lymphocyte transplantation .
19738030	0	FOXP3	10,15	CD4	41,44	FOXP3	CD4	50943	920	Gene	Gene	cells|nsubj|START_ENTITY cells|amod|active active|nmod|CD25 CD25|compound|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19738030	0	FOXP3	113,118	CD4	41,44	FOXP3	CD4	50943	920	Gene	Gene	mutations|compound|START_ENTITY carriers|nmod|mutations cells|nmod|carriers cells|amod|active active|nmod|CD25 CD25|compound|END_ENTITY	Wild-type FOXP3 is selectively active in CD4 + CD25 -LRB- hi -RRB- regulatory T cells of healthy female carriers of different FOXP3 mutations .
19752528	0	FOXP3	28,33	CD4	12,15	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD4 + CD25 bright FOXP3 + T cells are up-regulated by biological therapies and correlate with the clinical response in psoriasis patients .
19808957	0	FOXP3	23,28	CD4	30,33	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tumor antigen-specific FOXP3 + CD4 T cells identified in human metastatic melanoma : peptide vaccination results in selective expansion of Th1-like counterparts .
19822903	0	FOXP3	127,132	CD4	41,44	FOXP3	CD4	50943	920	Gene	Gene	T|compound|START_ENTITY induction|nmod|T associated|dep|induction associated|nsubj|expression expression|nmod|cells cells|amod|FOXP3 FOXP3|nmod|T T|compound|END_ENTITY	ATG-induced expression of FOXP3 in human CD4 -LRB- + -RRB- T cells in vitro is associated with T-cell activation and not the induction of FOXP3 -LRB- + -RRB- T regulatory cells .
19822903	0	FOXP3	26,31	CD4	41,44	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	ATG-induced expression of FOXP3 in human CD4 -LRB- + -RRB- T cells in vitro is associated with T-cell activation and not the induction of FOXP3 -LRB- + -RRB- T regulatory cells .
19875613	0	FOXP3	67,72	CD4	87,90	FOXP3	CD4	50943	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|CD25 CD25|compound|END_ENTITY	Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T-cells of type 1 diabetic subjects .
19877016	0	FOXP3	70,75	CD4	66,69	FOXP3	CD4	50943	920	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Phenotypic analysis of human peripheral blood regulatory T cells -LRB- CD4 + FOXP3 + CD127lo / - -RRB- ex vivo and after in vitro restimulation with malaria antigens .
19957514	0	FOXP3	15,20	CD4	24,27	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	-LSB- Expression of FOXP3 in CD4 + CD39 + T cells of patients with systemic_lupus_erythematosus and dynamic observation of treatment with glucocorticoid -RSB- .
20039297	0	FOXP3	25,30	CD4	21,24	FOXP3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	In vivo depletion of CD4 + FOXP3 + Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII + phagocytes .
20137305	0	FOXP3	90,95	CD4	77,80	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Combination of dexamethasone with IL-2 selectively induces the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft versus host disease . -RSB- .
20172352	0	FOXP3	72,77	CD4	59,62	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|generation generation|nmod|CD25 CD25|compound|END_ENTITY	Dendritic cells and B cells cooperate in the generation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- allogeneic T cells .
20302964	0	FOXP3	27,32	CD4	13,16	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Frequency Frequency|nmod|CD25 CD25|compound|END_ENTITY	Frequency of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host-disease .
20338811	0	FOXP3	4,9	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + FOXP3 + regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy .
20477619	0	FOXP3	13,18	CD4	22,25	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Influence of FOXP3 on CD4 + CD25 + regulatory T cells .
20498045	0	FOXP3	50,55	CD4	41,44	FOXP3	CD4	50943	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	In vivo expansion of naive and activated CD4 + CD25 + FOXP3 + regulatory T cell populations in interleukin-2-treated HIV patients .
20631311	0	FOXP3	49,54	CD4	56,59	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD30 discriminates heat_shock protein 60-induced FOXP3 + CD4 + T cells with a regulatory phenotype .
20821728	0	FOXP3	39,44	CD4	34,37	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Influenza matrix 1-specific human CD4 + FOXP3 + and FOXP3 -LRB- - -RRB- regulatory T cells can be detected long after viral clearance .
20854875	0	FOXP3	31,36	CD4	20,23	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY increased|nsubjpass|cells increased|dep|occurring occurring|dobj|+ +|compound|END_ENTITY	Naturally occurring CD4 + CD25 + FOXP3 + T-regulatory cells are increased in chronic_myeloid_leukemia patients not in complete cytogenetic remission and can be immunosuppressive .
20858449	0	FOXP3	41,46	CD4	32,35	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Circulating regulatory T cells -LRB- CD4 + CD25 + FOXP3 + -RRB- decrease in breast_cancer patients after vaccination with a modified MHC class II HER2/neu -LRB- AE37 -RRB- peptide .
21074227	0	FOXP3	74,79	CD4	105,108	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|dobj|level level|nmod|T-cells T-cells|compound|END_ENTITY	Comparative study of the plasma globulin level , CD21 -LRB- - -RRB- B-cell counts and FOXP3 mRNA expression level in CD4 -LRB- + -RRB- T-cells for different clinical stages of feline_immunodeficiency_virus infected cats .
21107346	0	FOXP3	50,55	CD4	37,40	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Mechanisms Mechanisms|nmod|regulation regulation|nmod|CD25 CD25|compound|END_ENTITY	Mechanisms of impaired regulation by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in human autoimmune_diseases .
21381018	0	FOXP3	0,5	CD4	7,10	FOXP3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	FOXP3 + CD4 + Tregs lose suppressive potential but remain anergic during transient inflammation in human .
21437244	0	FOXP3	63,68	CD4	52,55	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intracerebral human regulatory T cells : analysis of CD4 + CD25 + FOXP3 + T cells in brain_lesions and cerebrospinal fluid of multiple_sclerosis patients .
21691076	0	FOXP3	139,144	CD4	113,116	FOXP3	CD4	50943	920	Gene	Gene	Forkhead_Boxp3|appos|START_ENTITY Forkhead_Boxp3|compound|END_ENTITY	Intrapulmonary delivery of human umbilical cord mesenchymal stem cells attenuates acute_lung_injury by expanding CD4 + CD25 + Forkhead_Boxp3 -LRB- FOXP3 -RRB- + regulatory T cells and balancing anti- and pro-inflammatory factors .
21791023	0	FOXP3	36,41	CD4	14,17	FOXP3	CD4	50943	920	Gene	Gene	forkhead_box_P3|appos|START_ENTITY forkhead_box_P3|nummod|+ +|compound|END_ENTITY	Expression of CD4 + forkhead_box_P3 -LRB- FOXP3 -RRB- + regulatory T cells in inflammatory_bowel_disease .
21799858	0	FOXP3	113,118	CD4	23,26	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY generated|nsubj|cells +|parataxis|generated +|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21799858	0	FOXP3	113,118	CD4	95,98	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY generated|nsubj|cells +|parataxis|generated +|nmod|CD127 CD127|compound|END_ENTITY	Requirement of cognate CD4 + T-cell recognition for the regulation of allospecific CTL by human CD4 + CD127 - CD25 + FOXP3 + cells generated in MLR .
21829534	0	FOXP3	129,134	CD4	30,33	FOXP3	CD4	50943	920	Gene	Gene	compartment|compound|START_ENTITY undetectable|nmod|compartment cells|acl|undetectable T|dep|cells NY-ESO-1-specific|nsubj|T NY-ESO-1-specific|advcl|circulating circulating|dobj|cells cells|nummod|END_ENTITY	NY-ESO-1-specific circulating CD4 + T cells in ovarian_cancer patients are prevalently T -LRB- H -RRB- 1 type cells undetectable in the CD25 + FOXP3 + Treg compartment .
21856944	0	FOXP3	4,9	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FOXP3 + T regulatory cells in human autoimmunity : more than a numbers game .
21865550	0	FOXP3	39,44	CD4	54,57	FOXP3	CD4	50943	920	Gene	Gene	induction|nmod|START_ENTITY promotes|dobj|induction promotes|nmod|cells cells|compound|END_ENTITY	Low-dose antigen promotes induction of FOXP3 in human CD4 + T cells .
21897268	0	FOXP3	48,53	CD4	44,47	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Immunofluorescence-detected infiltration of CD4 + FOXP3 + regulatory T cells is relevant to the prognosis of patients with endometrial_cancer .
21934066	0	FOXP3	34,39	CD4	118,121	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY circulating|dobj|+ proportions|acl|circulating associated|nsubjpass|proportions associated|nmod|fractions fractions|nmod|cells cells|compound|END_ENTITY	Higher proportions of circulating FOXP3 + and CTLA-4 + regulatory T cells are associated with lower fractions of memory CD4 + T cells in infants .
21998454	0	FOXP3	131,136	CD4	49,52	FOXP3	CD4	50943	920	Gene	Gene	+|nummod|START_ENTITY naive|nmod:npmod|+ cells|amod|naive Th17|nmod|cells differentiation|nmod|Th17 identifies|nmod|differentiation identifies|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	Ex vivo IL-1 receptor type I expression in human CD4 + T cells identifies an early intermediate in the differentiation of Th17 from FOXP3 + naive regulatory T cells .
22087344	0	FOXP3	26,31	CD4	13,16	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|CD25 CD25|compound|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells during human hookworm_infection modulates antigen-mediated lymphocyte proliferation .
22214248	0	FOXP3	17,22	CD4	64,67	FOXP3	CD4	50943	920	Gene	Gene	Up-regulation|nmod|START_ENTITY function|nsubj|Up-regulation function|nmod|T-cells T-cells|compound|END_ENTITY	Up-regulation of FOXP3 and induction of suppressive function in CD4 + Jurkat T-cells expressing hepatitis_C virus core protein .
22267598	0	FOXP3	109,114	CD4	126,129	FOXP3	CD4	50943	920	Gene	Gene	ratios|appos|START_ENTITY ratios|appos|END_ENTITY	Necrotising_enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory -LRB- FOXP3 -RRB- / effector -LRB- CD4 , CD8 -RRB- T cell ratios .
22276195	0	FOXP3	44,49	CD4	28,31	FOXP3	CD4	50943	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22310634	0	FOXP3	25,30	CD4	12,15	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Absolute Absolute|nmod|CD25 CD25|compound|END_ENTITY	Absolute of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T-cell count rather than its ratio in peripheral blood is related to long-term survival of renal allografts .
22471961	0	FOXP3	58,63	CD4	52,55	FOXP3	CD4	50943	920	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Differential pattern and prognostic significance of CD4 + , FOXP3 + and IL-17 + tumor infiltrating lymphocytes in ductal_and_lobular_breast_cancers .
22585562	0	FOXP3	56,61	CD4	45,48	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Phenotypic and functional characteristics of CD4 + CD39 + FOXP3 + and CD4 + CD39 + FOXP3neg T-cell subsets in cancer patients .
22586481	0	FOXP3	25,30	CD4	31,34	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interleukin-7 influences FOXP3 + CD4 + regulatory T cells peripheral homeostasis .
22670785	0	FOXP3	32,37	CD4	25,28	FOXP3	CD4	50943	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripherally circulating CD4 FOXP3 CXCR3 T regulatory cells correlate with renal allograft function .
22891772	0	FOXP3	90,95	CD4	44,47	FOXP3	CD4	50943	920	Gene	Gene	T|nsubj|START_ENTITY T|dep|modulates modulates|dobj|conversion conversion|nmod|CD25 CD25|compound|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22891772	0	FOXP3	90,95	CD4	71,74	FOXP3	CD4	50943	920	Gene	Gene	T|nsubj|START_ENTITY T|nmod|CD25 CD25|compound|END_ENTITY	Ribavirin modulates the conversion of human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cell to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T cell via suppressing interleukin-10-producing regulatory T cell .
22956260	0	FOXP3	85,90	CD4	70,73	FOXP3	CD4	50943	920	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Skewed immunological balance between Th17 -LRB- CD4 -LRB- + -RRB- IL17A -LRB- + -RRB- -RRB- and Treg -LRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- -RRB- cells in human oral_squamous_cell_carcinoma .
23019018	0	FOXP3	56,61	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	cells|nummod|START_ENTITY phenotype|nmod|cells assessment|nmod|phenotype CD127|dep|assessment CD127|compound|END_ENTITY	CD4 + CD25 + CD127 - assessment as a surrogate phenotype for FOXP3 + regulatory T cells in HIV-1 infected viremic and aviremic subjects .
23019301	0	FOXP3	15,20	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 CD25 FOXP3 regulatory T cells in peripheral blood and peritoneal fluid of patients with endometriosis .
23251077	0	FOXP3	82,87	CD4	78,81	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Conditioned medium from adipose tissue-derived mesenchymal stem cells induces CD4 + FOXP3 + cells and increases IL-10 secretion .
23252864	0	FOXP3	27,32	CD4	16,19	FOXP3	CD4	50943	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Crucial role of CD4 + CD_25 + FOXP3 + T regulatory cell , interferon-y and interleukin-16 in malignant and tuberculous_pleural_effusions .
23340699	0	FOXP3	21,26	CD4	8,11	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lack of CD4 CD25 FOXP3 regulatory T cells is associated with resistance to intravenous immunoglobulin therapy in patients with Kawasaki_disease .
23432692	0	FOXP3	65,70	CD4	50,53	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|nsubj|Frequency Frequency|nmod|markers markers|nmod|CD25 CD25|compound|END_ENTITY	Frequency and expression of inhibitory markers of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in patients with common variable immunodeficiency .
23509755	0	FOXP3	11,16	CD4	0,3	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + FOXP3 + Treg cells induced by rSSP4 derived from T. _ cruzi amastigotes increase parasitemia in an experimental Chagas_disease model .
23964278	0	FOXP3	28,33	CD4	77,80	FOXP3	CD4	50943	920	Gene	Gene	Expression|nmod|START_ENTITY T|nsubj|Expression T|dobj|Induced Induced|nmod|Stimulation Stimulation|nmod|Effectors Effectors|compound|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
23968847	0	FOXP3	56,61	CD4	45,48	FOXP3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Influences of cerebral stent implantation on CD4 + CD25 + FOXP3 + Treg , Th1 and Th17 cells .
23993302	0	FOXP3	23,28	CD4	83,86	FOXP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY depletion|nmod|cells occurs|nsubj|depletion occurs|nmod|CD25 CD25|compound|END_ENTITY	Selective depletion of FOXP3 -LRB- high -RRB- cells by Fas-Fas-L-induced apoptosis occurs in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - enriched populations during repeated expansion .
24076591	0	FOXP3	57,62	CD4	48,51	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Arteether exerts antitumor activity and reduces CD4 + CD25 + FOXP3 + T-reg cells in vivo .
24244610	0	FOXP3	40,45	CD4	30,33	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
24264641	0	FOXP3	34,39	CD4	23,26	FOXP3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased frequency of CD4 + CD25 + FOXP3 + cells correlates with the progression of 4-nitroquinoline1-oxide-induced rat tongue carcinogenesis .
24316592	0	FOXP3	71,76	CD4	80,83	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Up-regulation of microRNA-210 induces immune_dysfunction via targeting FOXP3 in CD4 -LRB- + -RRB- T cells of psoriasis_vulgaris .
24337481	0	FOXP3	91,96	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	transfer|compound|START_ENTITY convert|nmod|transfer convert|nsubj|cells cells|compound|END_ENTITY	CD4 T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer .
24338252	0	FOXP3	53,58	CD4	40,43	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Alteration in frequency and function of CD4 CD25 FOXP3 regulatory T cells in patients with immune_thrombocytopenic_purpura .
24345703	0	FOXP3	20,25	CD4	11,14	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Changes of CD4 + CD25 + FOXP3 + and CD8 + CD28 - regulatory T cells in non-small_cell_lung_cancer patients undergoing surgery .
24368924	0	FOXP3	43,48	CD4	34,37	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	An imbalance between frequency of CD4 + CD25 + FOXP3 + regulatory T cells and CCR4 + and CCR9 + circulating helper T cells is associated with active perennial allergic_conjunctivitis .
24369813	0	FOXP3	13,18	CD4	0,3	FOXP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 CD25 FOXP3 T cells , Foxp3 gene and protein expression contribute to antiasthmatic effects of San ` ao_decoction in mice model of asthma .
24454972	0	FOXP3	42,47	CD4	28,31	FOXP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
24661230	0	FOXP3	17,22	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FOXP3 -LRB- + -RRB- regulatory T cells correlate with FEV1 in North Indian children with cystic fibrosis .
24703254	0	FOXP3	4,9	CD4	0,3	FOXP3	CD4	491876(Tax:9615)	403931(Tax:9615)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FOXP3 + cells produce IL-10 in the spleens of dogs with visceral_leishmaniasis .
24995020	0	FOXP3	53,58	CD4	36,39	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Interplay Interplay|nmod|Cells Cells|nmod|CD25 CD25|compound|END_ENTITY	Interplay of T Helper 17 Cells with CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FOXP3 -LRB- + -RRB- Tregs in Regulation of Allergic_Asthma in Pediatric Patients .
25099367	0	FOXP3	0,5	CD4	92,95	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|acl|overexpression overexpression|nmod|sign sign|nmod|accumulation accumulation|nmod|END_ENTITY	FOXP3 and CTLA4 overexpression in multiple myeloma bone marrow as a sign of accumulation of CD4 -LRB- + -RRB- T regulatory cells .
25205084	0	FOXP3	42,47	CD4	28,31	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY cells|dep|+ cells|dep|influence influence|nmod|therapy therapy|nmod|CD25 CD25|compound|END_ENTITY	The influence of therapy on CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in systemic_lupus_erythematosus patients : a prospective study .
25548591	1	FOXP3	157,162	CD4	144,147	FOXP3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Synovial_Inflammation Synovial_Inflammation|nmod|Rats Rats|nmod|Induction Induction|nmod|CD25 CD25|compound|END_ENTITY	Suppresses Synovial_Inflammation in Adjuvant_Arthritis Rats through Apoptosis Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- T Cells .
25657686	0	FOXP3	65,70	CD4	52,55	FOXP3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Immunotherapy Immunotherapy|nmod|glioma glioma|nmod|accumulation accumulation|nmod|CD25 CD25|compound|END_ENTITY	Immunotherapy of rat glioma without accumulation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells .
25740578	0	FOXP3	45,50	CD4	31,34	FOXP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|nsubj|Changes Changes|nmod|CD25 CD25|compound|END_ENTITY	Changes of Naturally Occurring CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- Regulatory T Cells in Patients With Acute_Coronary_Syndrome and the Beneficial Effects of Atorvastatin Treatment .
25950023	0	FOXP3	136,141	CD4	127,130	FOXP3	CD4	491876(Tax:9615)	403931(Tax:9615)	Gene	Gene	CELLS|compound|START_ENTITY CELLS|compound|END_ENTITY	EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4 + CD25 + FOXP3 + REGULATORY T CELLS .
26166019	0	FOXP3	45,50	CD4	36,39	FOXP3	CD4	50943	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26467610	0	FOXP3	56,61	CD4	84,87	FOXP3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY expression|nmod|Treg usage|appos|expression subsets|nsubj|usage subsets|nmod|CD25 CD25|compound|END_ENTITY	TCR usage , gene expression and function of two distinct FOXP3 -LRB- + -RRB- Treg subsets within CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- T cells identified by expression of CD39 and CD45RO .
26673957	0	FOXP3	40,45	CD4	27,30	FOXP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Mechanisms Mechanisms|nmod|CD25 CD25|compound|END_ENTITY	Accumulation Mechanisms of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- Regulatory T Cells in EBV-associated Gastric_Carcinoma .
26709833	0	FOXP3	4,9	CD4	0,3	FOXP3	CD4	50943	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	CD4 + FOXP3 + Regulatory T Cells Exhibit Impaired Ability to Suppress Effector T Cell Proliferation in Patients with Turner_Syndrome .
26962115	0	FOXP3	119,124	CD4	115,118	FOXP3	CD4	50943	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
26962115	0	FOXP3	119,124	CD4	91,94	FOXP3	CD4	50943	920	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|Cells Conversion|dep|Cells Conversion|nmod|FOXP3 FOXP3|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
26962115	0	FOXP3	95,100	CD4	115,118	FOXP3	CD4	50943	920	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|dep|Cells Cells|nmod|Cells Cells|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
27007547	0	FOXP3	85,90	CD4	56,59	FOXP3	CD4	50943	920	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	Healthy preterm newborns show an increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- CD127 -LRB- low -RRB- FOXP3 -LRB- + -RRB- regulatory T cells with a naive phenotype and high expression of gut-homing receptors .
27036917	0	FOXP3	81,86	CD4	88,91	FOXP3	CD4	574303(Tax:9544)	713807(Tax:9544)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|Cells Cells|compound|END_ENTITY	Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3 + CD4 + T Cells in the Fetal Rhesus_Macaque .
15226269	0	FOXP3	31,36	CD8	21,24	FOXP3	CD8	50943	925	Gene	Gene	cells|nummod|START_ENTITY induce|nsubj|cells CD28|parataxis|induce CD28|compound|END_ENTITY	Alloantigen specific CD8 + CD28 - FOXP3 + T suppressor cells induce ILT3 + ILT4 + tolerogenic endothelial cells , inhibiting alloreactivity .
17258077	0	FOXP3	31,36	CD8	45,48	FOXP3	CD8	50943	925	Gene	Gene	CD4|compound|START_ENTITY generation|nmod|CD4 IL-2-independent|dobj|generation IL-2-independent|dep|END_ENTITY	IL-2-independent generation of FOXP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- cytotoxic regulatory T cell lines from human umbilical cord blood .
17414320	0	FOXP3	49,54	CD8	98,101	FOXP3	CD8	50943	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells .
18089323	0	FOXP3	4,9	CD8	0,3	FOXP3	CD8	50943	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD8 + FOXP3 + T cells from renal transplant recipients in quiescence induce immunoglobulin-like_transcripts-3_and _ -4 on dendritic cells from their respective donors .
18266270	0	FOXP3	55,60	CD8	42,45	FOXP3	CD8	50943	925	Gene	Gene	START_ENTITY|nsubj|Generation Generation|nmod|CD25 CD25|compound|END_ENTITY	Generation of highly suppressive adaptive CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells by continuous antigen stimulation .
18504453	0	FOXP3	4,9	CD8	31,34	FOXP3	CD8	50943	925	Gene	Gene	subset|compound|START_ENTITY subset|nmod|thymocytes thymocytes|compound|END_ENTITY	The FOXP3 + subset of human CD4 + CD8 + thymocytes is immature and subject to intrathymic selection .
19201865	0	FOXP3	57,62	CD8	63,66	FOXP3	CD8	50943	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Unique phenotype of human tonsillar and in vitro-induced FOXP3 + CD8 + T cells .
20053943	0	FOXP3	13,18	CD8	20,23	FOXP3	CD8	50943	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expansion of FOXP3 + CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian_immunodeficiency_virus infection correlates with diminished antiviral T cell response and viral control .
21996189	0	FOXP3	87,92	CD8	23,26	FOXP3	CD8	50943	925	Gene	Gene	protein|compound|START_ENTITY express|dobj|protein CD28|parataxis|express CD28|compound|END_ENTITY	Human peripheral blood CD8 + CD28 - T cells of renal allograft recipients do not express FOXP3 protein .
22267598	0	FOXP3	109,114	CD8	131,134	FOXP3	CD8	50943	925	Gene	Gene	ratios|appos|START_ENTITY ratios|appos|CD4 CD4|dep|END_ENTITY	Necrotising_enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory -LRB- FOXP3 -RRB- / effector -LRB- CD4 , CD8 -RRB- T cell ratios .
22821963	0	FOXP3	16,21	CD8	0,3	FOXP3	CD8	50943	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + CD45RA + CCR7 + FOXP3 + T cells with immunosuppressive properties : a novel subset of inducible human regulatory T cells .
24244610	0	FOXP3	40,45	CD8	14,17	FOXP3	CD8	50943	925	Gene	Gene	+|compound|START_ENTITY T|nmod|+ T|nsubj|ratios ratios|nmod|+ +|compound|END_ENTITY	The ratios of CD8 + T cells to CD4 + CD25 + FOXP3 + and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian_cancer .
25202922	0	FOXP3	155,160	CD8	151,154	FOXP3	CD8	50943	925	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	HIV-1 Shedding From the Female Genital Tract is Associated With Increased Th1 Cytokines/Chemokines That Maintain Tissue Homeostasis and Proportions of CD8 + FOXP3 + T Cells .
20394075	0	FOXP3	68,73	CD8alpha	0,8	FOXP3	CD8alpha	20371(Tax:10090)	12525(Tax:10090)	Gene	Gene	cells|dep|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD8alpha + dendritic cells prime TCR-peptide-reactive regulatory CD4 + FOXP3 - T cells .
23252864	0	FOXP3	27,32	CD_25	20,25	FOXP3	CD 25	50943	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Crucial role of CD4 + CD_25 + FOXP3 + T regulatory cell , interferon-y and interleukin-16 in malignant and tuberculous_pleural_effusions .
22319577	0	FOXP3	30,35	CTLA-4	23,29	FOXP3	CTLA-4	50943	1493	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Accumulation of CCR4 CTLA-4 FOXP3 CD25 -LRB- hi -RRB- regulatory T cells in colon_adenocarcinomas correlate to reduced activation of conventional T cells .
24870556	0	FOXP3	45,50	CXCL12	98,104	FOXP3	CXCL12	50943	6387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Breast_cancer metastasis : demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12 .
22670785	0	FOXP3	32,37	CXCR3	41,46	FOXP3	CXCR3	50943	2833	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Peripherally circulating CD4 FOXP3 CXCR3 T regulatory cells correlate with renal allograft function .
24870556	0	FOXP3	45,50	CXCR4	61,66	FOXP3	CXCR4	50943	7852	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Breast_cancer metastasis : demonstration that FOXP3 regulates CXCR4 expression and the response to CXCL12 .
26060310	0	FOXP3	34,39	DBC1	75,79	FOXP3	DBC1	20371(Tax:10090)	56710(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1 .
19767570	0	FOXP3	24,29	Dab2	14,18	FOXP3	Dab2	20371(Tax:10090)	13132(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Cutting edge : Dab2 is a FOXP3 target gene required for regulatory T cell function .
17644734	0	FOXP3	13,18	FOXP3	49,54	FOXP3	FOXP3	50943	50943	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Induction of FOXP3 expression in naive human CD4 + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype .
17644734	0	FOXP3	49,54	FOXP3	13,18	FOXP3	FOXP3	50943	50943	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nummod|END_ENTITY	Induction of FOXP3 expression in naive human CD4 + FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype .
21272943	0	FOXP3	26,31	FOXP3	38,43	FOXP3	FOXP3	100240742(Tax:9940)	100240742(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the ovine FOXP3 gene -LRB- FOXP3 -RRB- .
21272943	0	FOXP3	38,43	FOXP3	26,31	FOXP3	FOXP3	100240742(Tax:9940)	100240742(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism of the ovine FOXP3 gene -LRB- FOXP3 -RRB- .
26962115	0	FOXP3	119,124	FOXP3	95,100	FOXP3	FOXP3	50943	50943	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|Cells Conversion|dep|Cells Conversion|nmod|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
26962115	0	FOXP3	95,100	FOXP3	119,124	FOXP3	FOXP3	50943	50943	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|dep|Cells Cells|nmod|Cells Cells|compound|END_ENTITY	JEG-3 Trophoblast Cells Producing Human Chorionic Gonadotropin Promote Conversion of Human CD4 + FOXP3 - T Cells into CD4 + FOXP3 + Regulatory T Cells and Foster T Cell Suppressive Activity .
19364305	0	FOXP3	17,22	Forkhead_box_P3	0,15	FOXP3	Forkhead box P3	50943	50943	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Forkhead_box_P3 -LRB- FOXP3 -RRB- mRNA expression immediately after living-donor liver transplant .
24369813	0	FOXP3	13,18	Foxp3	31,36	FOXP3	Foxp3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|dep|gene gene|dep|END_ENTITY	CD4 CD25 FOXP3 T cells , Foxp3 gene and protein expression contribute to antiasthmatic effects of San ` ao_decoction in mice model of asthma .
23359504	0	FOXP3	53,58	Helios	0,6	FOXP3	Helios	50943	22807	Gene	Gene	subset|compound|START_ENTITY coexist|nmod|subset cells|acl|coexist +|dep|cells +|compound|END_ENTITY	Helios + and Helios - cells coexist within the natural FOXP3 + T regulatory cell subset in humans .
24068664	0	FOXP3	21,26	Helios	13,19	FOXP3	Helios	50943	22807	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Human memory Helios - FOXP3 + regulatory T cells -LRB- Tregs -RRB- encompass induced Tregs that express Aiolos and respond to IL-1b by downregulating their suppressor functions .
25446972	0	FOXP3	109,114	Helios	97,103	FOXP3	Helios	50943	22807	Gene	Gene	Treg|compound|START_ENTITY END_ENTITY|appos|Treg	Differential expression of the immunosuppressive enzyme IL4I1 induce Aiolos -LRB- + -RRB- , but not natural Helios -LRB- + -RRB- , FOXP3 -LRB- + -RRB- Treg cells .
24703254	0	FOXP3	4,9	IL-10	25,30	FOXP3	IL-10	491876(Tax:9615)	403628(Tax:9615)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|xcomp|END_ENTITY	CD4 + FOXP3 + cells produce IL-10 in the spleens of dogs with visceral_leishmaniasis .
24984993	0	FOXP3	45,50	IL-10	64,69	FOXP3	IL-10	50943	3586	Gene	Gene	cells|nummod|START_ENTITY cells|appos|END_ENTITY	Modulation of adipose tissue inflammation by FOXP3 + Treg cells , IL-10 , and TGF-b in metabolically healthy class III_obese individuals .
22522772	0	FOXP3	23,28	IL-17	16,21	FOXP3	IL-17	50943	3605	Gene	Gene	cells|nummod|START_ENTITY presence|dep|cells presence|nmod|+ +|compound|END_ENTITY	The presence of IL-17 + / FOXP3 + double-positive cells in periodontitis .
16645171	0	FOXP3	15,20	IL-2	0,4	FOXP3	IL-2	50943	3558	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
17414320	0	FOXP3	49,54	IL-2	0,4	FOXP3	IL-2	50943	3558	Gene	Gene	expression|nummod|START_ENTITY induction|nmod|expression END_ENTITY|dep|induction	IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells .
19234188	0	FOXP3	72,77	IL-2	58,62	FOXP3	IL-2	50943	3558	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Analysis of adhesion molecules , target cells , and role of IL-2 in human FOXP3 + regulatory T cell suppressor function .
20137305	0	FOXP3	90,95	IL-2	35,39	FOXP3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	-LSB- Combination of dexamethasone with IL-2 selectively induces the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft versus host disease . -RSB- .
21179414	0	FOXP3	45,50	IL-2	85,89	FOXP3	IL-2	50943	3558	Gene	Gene	START_ENTITY|ccomp|generated generated|nmod|END_ENTITY	Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2 , TGF-b and retinoic_acid .
22276195	0	FOXP3	44,49	IL-2	114,118	FOXP3	IL-2	50943	3558	Gene	Gene	+|nsubj|START_ENTITY +|nmod|administration administration|compound|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22969764	0	FOXP3	102,107	IL-2	0,4	FOXP3	IL-2	50943	3558	Gene	Gene	Levels|nmod|START_ENTITY Depends|nmod|Levels Cells|dobj|Depends Cells|nsubj|Expression Expression|compound|END_ENTITY	IL-2 Expression in Activated Human Memory FOXP3 -LRB- + -RRB- Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of T Cell Activation .
22969764	0	FOXP3	42,47	IL-2	0,4	FOXP3	IL-2	50943	3558	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	IL-2 Expression in Activated Human Memory FOXP3 -LRB- + -RRB- Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of T Cell Activation .
23129754	0	FOXP3	54,59	IL-7	0,4	FOXP3	IL-7	50943	3574	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells abrogates|dobj|activity abrogates|nsubj|END_ENTITY	IL-7 abrogates suppressive activity of human CD4 + CD25 + FOXP3 + regulatory T cells and allows expansion of alloreactive and autoreactive T cells .
24947990	0	FOXP3	94,99	IL-7	57,61	FOXP3	IL-7	50943	3574	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4 + FOXP3 - cells versus regulatory T cells : a whole blood perspective .
17671219	0	FOXP3	44,49	Interleukin-2	0,13	FOXP3	Interleukin-2	50943	3558	Gene	Gene	pool|compound|START_ENTITY alters|dobj|pool alters|nsubj|administration administration|amod|END_ENTITY	Interleukin-2 administration alters the CD4 + FOXP3 + T-cell pool and tumor trafficking in patients with ovarian_carcinoma .
22586481	0	FOXP3	25,30	Interleukin-7	0,13	FOXP3	Interleukin-7	20371(Tax:10090)	16196(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nsubj|+ influences|xcomp|cells influences|nsubj|END_ENTITY	Interleukin-7 influences FOXP3 + CD4 + regulatory T cells peripheral homeostasis .
25485946	0	FOXP3	24,29	Interleukin-7	0,13	FOXP3	Interleukin-7	20371(Tax:10090)	16196(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
19299332	0	FOXP3	120,125	LAP	52,55	FOXP3	LAP	50943	7040	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|latency-associated_peptide latency-associated_peptide|appos|END_ENTITY	Selective expression of latency-associated_peptide -LRB- LAP -RRB- and IL-1 receptor type I/II -LRB- CD121a/CD121b -RRB- on activated human FOXP3 + regulatory T cells allows for their purification from expansion cultures .
19564342	0	FOXP3	0,5	NFAT2	34,39	FOXP3	FOXP3	50943	50943	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression .
26166019	0	FOXP3	45,50	PD-L1	27,32	FOXP3	PD-L1	50943	29126	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
22896699	0	FOXP3	76,81	Polycomb	0,8	FOXP3	Polycomb	20371(Tax:10090)	12416(Tax:10090)	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner .
18008005	0	FOXP3	0,5	SKP2	74,78	FOXP3	SKP2	50943	6502	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	FOXP3 is a novel transcriptional repressor for the breast_cancer oncogene SKP2 .
18025205	0	FOXP3	26,31	STAT3	8,13	FOXP3	STAT3	20371(Tax:10090)	20848(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
24947990	0	FOXP3	94,99	STAT5	65,70	FOXP3	STAT5	50943	6776	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4 + FOXP3 - cells versus regulatory T cells : a whole blood perspective .
24454972	0	FOXP3	42,47	TGF-b	12,17	FOXP3	TGF-b	50943	7040	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
18779564	0	FOXP3	90,95	TGF-beta	0,8	FOXP3	TGF-beta	50943	7040	Gene	Gene	modulate|nmod|START_ENTITY modulate|nsubj|signals signals|amod|END_ENTITY	TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3 .
17641056	0	FOXP3	0,5	TLR10	16,21	FOXP3	TLR10	50943	81793	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	FOXP3 regulates TLR10 expression in human T regulatory cells .
20127680	0	FOXP3	70,75	TNFR2	17,22	FOXP3	TNFR2	50943	7133	Gene	Gene	more|nmod|START_ENTITY +|nsubj|more identifies|dep|+ identifies|nsubj|Co-expression Co-expression|nmod|END_ENTITY	Co-expression of TNFR2 and CD25 identifies more of the functional CD4 + FOXP3 + regulatory T cells in human peripheral blood .
23964278	0	FOXP3	28,33	TNFR2	0,5	FOXP3	TNFR2	50943	7133	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
25202922	0	FOXP3	155,160	Th1	74,77	FOXP3	Th1	50943	51497	Gene	Gene	Cells|compound|START_ENTITY Homeostasis|nmod|Cells Cytokines/Chemokines|nsubj|Homeostasis Cytokines/Chemokines|dep|Associated Associated|nmod|END_ENTITY	HIV-1 Shedding From the Female Genital Tract is Associated With Increased Th1 Cytokines/Chemokines That Maintain Tissue Homeostasis and Proportions of CD8 + FOXP3 + T Cells .
23202541	0	FOXP3	13,18	VEGFR2	19,25	FOXP3	VEGFR2	50943	3791	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intratumoral FOXP3 + VEGFR2 + regulatory T cells are predictive markers for recurrence and survival in patients with colorectal_cancer .
19276356	0	FOXP3	0,5	histone_deacetylase_2	65,86	FOXP3	histone deacetylase 2	50943	3066	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	FOXP3 up-regulates p21 expression by site-specific inhibition of histone_deacetylase_2 / histone_deacetylase_4 association to the locus .
19299332	0	FOXP3	120,125	latency-associated_peptide	24,50	FOXP3	latency-associated peptide	50943	7040	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Selective expression of latency-associated_peptide -LRB- LAP -RRB- and IL-1 receptor type I/II -LRB- CD121a/CD121b -RRB- on activated human FOXP3 + regulatory T cells allows for their purification from expansion cultures .
26781862	0	FOXP3	33,38	p53	57,60	FOXP3	p53	50943	7157	Gene	Gene	Transcription|compound|START_ENTITY Transcription|nmod|END_ENTITY	Ultraviolet Irradiation Promotes FOXP3 Transcription via p53 in Psoriasis .
25856555	0	FOXQ1	65,70	MiR-506	0,7	FOXQ1	MiR-506	94234	574511	Gene	Gene	Suppresses|nmod|START_ENTITY Suppresses|nsubj|END_ENTITY	MiR-506 Suppresses Tumor Proliferation and Invasion by Targeting FOXQ1 in Nasopharyngeal_Carcinoma .
25287361	0	FOXQ1	16,21	TGF-b1	31,37	FOXQ1	TGF-b1	94234	7040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Forkhead factor FOXQ1 promotes TGF-b1 expression and induces epithelial-mesenchymal transition .
21909761	0	FPF1	71,75	Flowering_Promoting_Factor_1	36,64	FPF1	Flowering Promoting Factor 1	832555(Tax:3702)	832555(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Influence of over-expression of the Flowering_Promoting_Factor_1 gene -LRB- FPF1 -RRB- from Arabidopsis on wood formation in hybrid poplar -LRB- Populus tremula L. P. tremuloides Michx . -RRB- .
26107232	0	FPGS	79,83	Folylpolyglutamate_Synthetase	48,77	FPGS	Folylpolyglutamate Synthetase	2356	2356	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Mutation Screening and Association Study of the Folylpolyglutamate_Synthetase -LRB- FPGS -RRB- Gene with Susceptibility to Childhood_Acute_Lymphoblastic_Leukemia .
10477558	1	FPR	230,233	FPR2	198,202	FPR	FPR2	14293(Tax:10090)	14289(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Molecular characterization of FPR2 , a second mouse neutrophil FPR .
24778447	0	FPR1	97,101	CCR2	39,43	FPR1	CCR2	2357	729230	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Cross-desensitization of CCR1 , but not CCR2 , following activation of the formyl peptide receptor FPR1 .
25277308	0	FPR1	0,4	CFH	20,23	FPR1	CFH	2357	3075	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FPR1 interacts with CFH , HTRA1 and smoking in exudative age-related_macular_degeneration and polypoidal_choroidal_vasculopathy .
23185575	0	FPR1	45,49	formyl_peptide_receptor_1	18,43	FPR1	formyl peptide receptor 1	2357	2357	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of the formyl_peptide_receptor_1 -LRB- FPR1 -RRB- gene in primary human macrophages .
21216225	0	FPR1	50,54	formylpeptide_receptor	21,43	FPR1	formylpeptide receptor	2357	2357	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of the formylpeptide_receptor gene -LRB- FPR1 -RRB- and susceptibility to stomach_cancer in 1531 consecutive autopsy cases .
12270697	0	FPR2	17,21	A_beta	69,75	FPR2	A beta	14289(Tax:10090)	11820(Tax:10090)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of FPR2 , a chemotactic receptor for amyloid beta 1-42 -LRB- A_beta 42 -RRB- , in murine microglial cells by TNF_alpha .
10477558	1	FPR2	198,202	FPR	230,233	FPR2	FPR	14289(Tax:10090)	14293(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Molecular characterization of FPR2 , a second mouse neutrophil FPR .
10753626	0	FPR2	44,48	Serum_amyloid_A	0,15	FPR2	Serum amyloid A	14289(Tax:10090)	111345(Tax:10090)	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	Serum_amyloid_A is a chemotactic agonist at FPR2 , a low-affinity N-formylpeptide receptor on mouse neutrophils .
22123264	0	FPR2	56,60	annexin_A1	45,55	FPR2	annexin A1	2358	301	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Anti-inflammatory drugs , eicosanoids and the annexin_A1 / FPR2 anti-inflammatory system .
1612600	0	FPRH1	129,134	FMLP_receptor	87,100	FPRH1	FMLP receptor	2359	2357	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Mapping of genes for the human C5a_receptor -LRB- C5AR -RRB- , human FMLP_receptor -LRB- FPR -RRB- , and two FMLP_receptor homologue orphan receptors -LRB- FPRH1 , FPRH2 -RRB- to chromosome 19 .
12377930	0	FPRL1	54,59	formyl_peptide_receptor-like_1	22,52	FPRL1	formyl peptide receptor-like 1	2358	2358	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role of the formyl_peptide_receptor-like_1 -LRB- FPRL1 -RRB- in inflammatory aspects of Alzheimer 's _ disease .
19439472	0	FPV039	35,41	BCL-2	18,23	FPV039	BCL-2	1486587(Tax:10261)	596	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	The fowlpox_virus BCL-2 homologue , FPV039 , interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis .
23518909	0	FRA	33,36	folate_receptor-a	14,31	FRA	folate receptor-a	8061	8061	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of folate_receptor-a -LRB- FRA -RRB- in gynecologic malignancies and its relationship to the tumor type .
7914658	0	FRA	38,41	fos-related_antigen	17,36	FRA	fos-related antigen	80754(Tax:10116)	80754(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of a 35 kDa fos-related_antigen -LRB- FRA -RRB- in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat .
23482931	0	FRA-2	32,37	SOX4	0,4	FRA-2	SOX4	2355	6659	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult_T-cell_leukemia / lymphoma .
3780312	0	FRA16D	123,129	APRT	69,73	FRA16D	APRT	2463	353	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	A new location for the human adenine_phosphoribosyltransferase gene -LRB- APRT -RRB- distal to the haptoglobin -LRB- HP -RRB- and fra -LRB- 16 -RRB- -LRB- q23 -RRB- -LRB- FRA16D -RRB- loci .
11719429	0	FRA16D	10,16	WWOX	0,4	FRA16D	WWOX	2463	51741	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	WWOX , the FRA16D gene , behaves as a suppressor of tumor growth .
23765596	0	FRA16D	32,38	WWOX	56,60	FRA16D	WWOX	2463	51741	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells .
3780312	0	FRA16D	123,129	adenine_phosphoribosyltransferase	29,62	FRA16D	adenine phosphoribosyltransferase	2463	353	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new location for the human adenine_phosphoribosyltransferase gene -LRB- APRT -RRB- distal to the haptoglobin -LRB- HP -RRB- and fra -LRB- 16 -RRB- -LRB- q23 -RRB- -LRB- FRA16D -RRB- loci .
24587342	0	FRA2	0,4	STAT5	10,15	FRA2	STAT5	2355	6776	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells .
20060399	0	FRA3B	54,59	ATR	0,3	FRA3B	ATR	2272	545	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment .
9290949	0	FRA3B	76,81	FHIT	28,32	FRA3B	FHIT	2272	2272	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Precise localization of the FHIT gene to the common fragile site at 3p14 .2 -LRB- FRA3B -RRB- and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines .
6195834	0	FRAP	37,41	Fluoride-resistant_acid_phosphatase	0,35	FRAP	Fluoride-resistant acid phosphatase	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Fluoride-resistant_acid_phosphatase -LRB- FRAP -RRB- activity of nociceptive nerve terminals in the dental pulp .
2421214	0	FRAP	57,61	fluoride-resistant_acid_phosphatase	20,55	FRAP	fluoride-resistant acid phosphatase	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	The localization of fluoride-resistant_acid_phosphatase -LRB- FRAP -RRB- in the pelvic nerves and sacral spinal cord of rats .
12536050	0	FRAP	70,74	fluoride_resistant_acid_phosphatase	33,68	FRAP	fluoride resistant acid phosphatase	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inflammation induced increase of fluoride_resistant_acid_phosphatase -LRB- FRAP -RRB- activity in the spinal dorsal horn in rats .
11684675	0	FRAP	80,84	p70_S6_kinase	88,101	FRAP	p70 S6 kinase	2475	6198	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70_S6_kinase activation .
9867825	0	FREAC-4	55,62	Ets-1	79,84	FREAC-4	Ets-1	2297	2113	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The kidney-expressed winged helix transcription factor FREAC-4 is regulated by Ets-1 .
15491296	0	FREB	28,32	FCRL	22,26	FREB	FCRL	84824	84824	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of FCRL -LRB- FREB , FcRX -RRB- in normal and neoplastic human B cells .
22031191	0	FREM2	152,157	Fras-1-related_extracellular_matrix_protein	107,150	FREM2	Fras-1-related extracellular matrix protein	341640	341640	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the Fras-1-related_extracellular_matrix_protein -LRB- FREM2 -RRB- gene .
19607661	0	FRG1	138,142	FSHD-related_gene_1	117,136	FRG1	FSHD-related gene 1	2483	2483	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Remodeling of the chromatin structure of the facioscapulohumeral_muscular_dystrophy -LRB- FSHD -RRB- locus and upregulation of FSHD-related_gene_1 -LRB- FRG1 -RRB- expression during human myogenic differentiation .
21314676	0	FRGY2	61,66	Xtr	0,3	FRGY2	Xtr	397746(Tax:8355)	398252(Tax:8355)	Gene	Gene	coexists|nmod|START_ENTITY coexists|nsubj|END_ENTITY	Xtr , a plural tudor domain-containing protein , coexists with FRGY2 both in cytoplasmic mRNP particle and germ plasm in Xenopus embryo : its possible role in translational regulation of maternal mRNAs .
12569179	0	FRK	13,16	Fractalkine	0,11	FRK	Fractalkine	6376	6376	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Fractalkine -LRB- FRK -RRB- levels in amniotic fluid and its production during pregnancy .
16998626	0	FRNK	38,42	FAK-related_non-kinase	14,36	FRNK	FAK-related non-kinase	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of FAK-related_non-kinase -LRB- FRNK -RRB- coincides with morphological change in the early stage of cell adhesion .
23904105	0	FRNK	65,69	focal_adhesion_kinase	24,45	FRNK	focal adhesion kinase	5747	5747	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Quantitative changes in focal_adhesion_kinase and its inhibitor , FRNK , drive load-dependent expression of costamere components .
16741749	0	FRO2	122,126	reductase	106,115	FRO2	reductase	839411(Tax:3702)	547911(Tax:3847)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular and phenotypic characterization of transgenic soybean expressing the Arabidopsis ferric chelate reductase gene , FRO2 .
19841162	0	FROUNT	0,6	CCR2	32,36	FROUNT	CCR2	79902	729230	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	FROUNT is a common regulator of CCR2 and CCR5 signaling to control directional migration .
21193048	0	FROUNT	37,43	CCR2	77,81	FROUNT	CCR2	79902	729230	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|regulator regulator|nmod|END_ENTITY	Expression and purification of human FROUNT , a common cytosolic regulator of CCR2 and CCR5 .
24128342	0	FROUNT	66,72	CCR2	139,143	FROUNT	CCR2	79902	729230	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5 .
25283965	0	FROUNT	132,138	CCR2	98,102	FROUNT	CCR2	79902	729230	Gene	Gene	START_ENTITY|nsubj|basis basis|nmod|END_ENTITY	Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT .
10092678	0	FRS-2	22,27	Shc	42,45	FRS-2	Shc	10818	6464	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA .
12974390	0	FRS2	32,36	EGFR	0,4	FRS2	EGFR	10818	1956	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2 .
11463744	0	FRS2	8,12	Laloo	90,95	FRS2	Laloo	380490(Tax:8355)	373700(Tax:8355)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Xenopus FRS2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo .
20652960	0	FRS2a	0,5	Erk	16,19	FRS2a	Erk	327826(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	FRS2a regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells .
21284215	0	FRUITFULL	27,36	FUL	38,41	FRUITFULL	FUL	836212(Tax:3702)	836212(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Regulation pattern of the FRUITFULL -LRB- FUL -RRB- gene of Arabidopsis_thaliana -RSB- .
18605956	0	FSAP	61,65	factor_VII-activating_protease	29,59	FSAP	factor VII-activating protease	3026	3026	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Tests for the measurement of factor_VII-activating_protease -LRB- FSAP -RRB- activity and antigen levels in citrated plasma , their correlation to PCR testing , and utility for the detection of the Marburg I-polymorphism of FSAP .
22878700	0	FSAP	55,59	factor_VII_activating_protease	23,53	FSAP	factor VII activating protease	3026	3026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nicotine modulation of factor_VII_activating_protease -LRB- FSAP -RRB- expression in human monocytes .
23393326	0	FSCN1	31,36	fascin-1	21,29	FSCN1	fascin-1	6624	6624	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	Prognostic impact of fascin-1 -LRB- FSCN1 -RRB- in epithelial_ovarian_cancer .
25433493	0	FSCN1	46,51	microRNA-133b	12,25	FSCN1	microRNA-133b	6624	442890	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of microRNA-133b and its target gene FSCN1 in gastric_cancer .
10783262	0	FSCN2	47,52	retinal_fascin	26,40	FSCN2	retinal fascin	25794	337926(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of human retinal_fascin gene -LRB- FSCN2 -RRB- at 17q25 : close physical linkage of fascin and cytoplasmic actin genes .
26892346	0	FSGS	54,58	TRPC6	0,5	FSGS	TRPC6	81	7225	Gene	Gene	Associates|nmod|START_ENTITY Associates|compound|END_ENTITY	TRPC6 G757D Loss-of-Function Mutation Associates with FSGS .
15942677	0	FSGS	74,78	nephrin	82,89	FSGS	nephrin	81	4868	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Direct effect of plasma permeability factors from patients with idiopatic FSGS on nephrin and podocin expression in human podocytes .
8869593	0	FSH	81,84	follicle-stimulating_hormone	51,79	FSH	follicle-stimulating hormone	14308(Tax:10090)	14308(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Pituitary and ovarian expression of the endogenous follicle-stimulating_hormone -LRB- FSH -RRB- subunit genes and an FSH_beta-subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic_mice ; specific partial ablation of FSH-producing cells by antiherpes treatment .
15625767	0	FSH-R	45,50	follicle-stimulating_hormone_receptor	6,43	FSH-R	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Human follicle-stimulating_hormone_receptor -LRB- FSH-R -RRB- promoter/enhancer activity is inhibited by transcriptional factors , from the upstream stimulating factors family , via E-box and newly identified initiator element -LRB- Inr -RRB- in FSH-R non-expressing cells .
14697302	0	FSH-beta	30,38	LH-beta	162,169	FSH-beta	LH-beta	100174866(Tax:69293)	100174897(Tax:69293)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning and sequencing of the FSH-beta and LH_beta-subunit in the three-spined_stickleback , Gasterosteus_aculeatus , and effects of photoperiod and temperature on LH-beta and FSH-beta mRNA expression .
19607661	0	FSHD-related_gene_1	117,136	FRG1	138,142	FSHD-related gene 1	FRG1	2483	2483	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Remodeling of the chromatin structure of the facioscapulohumeral_muscular_dystrophy -LRB- FSHD -RRB- locus and upregulation of FSHD-related_gene_1 -LRB- FRG1 -RRB- expression during human myogenic differentiation .
17030088	0	FSHR	44,48	APPL1	0,5	FSHR	APPL1	2492	26060	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	APPL1 , APPL2 , Akt2 and FOXO1a interact with FSHR in a potential signaling complex .
19017414	0	FSHR	49,53	FSH_receptor	35,47	FSHR	FSH receptor	2492	2492	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations and polymorphisms of the FSH_receptor -LRB- FSHR -RRB- gene : clinical implications in female fecundity and molecular biology of FSHR protein and gene .
20642491	0	FSHR	32,36	FSH_receptor	18,30	FSHR	FSH receptor	397679(Tax:9823)	397679(Tax:9823)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of FSH_receptor -LRB- FSHR -RRB- in the neonatal porcine ovary and its regulation by flutamide .
20087398	0	FSHR	103,107	follicle-stimulating_hormone_receptor	64,101	FSHR	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene and causes FSH resistance .
20420197	0	FSHR	53,57	follicle-stimulating_hormone_receptor	14,51	FSHR	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- mRNA in the ovary of Zi geese during developmental and egg laying stages .
21865747	0	FSHR	74,78	follicle-stimulating_hormone_receptor	30,67	FSHR	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Influence of variation in the follicle-stimulating_hormone_receptor gene -LRB- FSHR -RRB- and age at menopause on the development of Alzheimer 's _ disease in women .
23086931	0	FSHR	164,168	follicle-stimulating_hormone_receptor	125,162	FSHR	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sertoli cell-specific expression of metastasis-associated_protein_2 -LRB- MTA2 -RRB- is required for transcriptional regulation of the follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene during spermatogenesis .
25365857	0	FSHR	74,78	follicle-stimulating_hormone_receptor	30,67	FSHR	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Asn680ser polymorphism of the follicle-stimulating_hormone_receptor gene -LRB- FSHR -RRB- is not associated with recurrent_pregnancy_loss -LRB- RPL -RRB- .
8432542	0	FSHR	86,90	follicle-stimulating_hormone_receptor	42,79	FSHR	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The chromosomal localization of the human follicle-stimulating_hormone_receptor gene -LRB- FSHR -RRB- on 2p21-p16 is similar to that of the luteinizing hormone receptor gene .
8661143	0	FSHR	83,87	follicle-stimulating_hormone_receptor	44,81	FSHR	follicle-stimulating hormone receptor	2492	2492	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The structure and organization of the human follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene .
9773974	0	FSHR	96,100	follicle-stimulating_hormone_receptor	57,94	FSHR	follicle-stimulating hormone receptor	25449(Tax:10116)	25449(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple promoter elements contribute to activity of the follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene in testicular Sertoli cells .
11123515	0	FSH_beta	52,60	LH_beta	81,88	FSH beta	LH beta	14308(Tax:10090)	16866(Tax:10090)	Gene	Gene	profile|nmod|START_ENTITY Manipulating|nmod|profile Manipulating|xcomp|resemble resemble|xcomp|that that|nmod|END_ENTITY	Manipulating the in vivo mRNA expression profile of FSH_beta to resemble that of LH_beta does not promote a concomitant increase in intracellular storage of follicle-stimulating hormone .
9229355	0	FSH_beta	41,49	LH_beta	31,38	FSH beta	LH beta	2488	3972	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Ontogeny of growth_hormone and LH_beta - , FSH_beta - and alpha-subunit mRNA levels in the porcine fetal and neonatal anterior pituitary .
20825377	0	FSH_receptor	66,78	Bone_morphogenetic_protein-2	0,28	FSH receptor	Bone morphogenetic protein-2	2492	650	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- increases gene expression of FSH_receptor and aromatase and decreases gene expression of LH_receptor and StAR in human granulosa cells .
19017414	0	FSH_receptor	35,47	FSHR	49,53	FSH receptor	FSHR	2492	2492	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations and polymorphisms of the FSH_receptor -LRB- FSHR -RRB- gene : clinical implications in female fecundity and molecular biology of FSHR protein and gene .
20642491	0	FSH_receptor	18,30	FSHR	32,36	FSH receptor	FSHR	397679(Tax:9823)	397679(Tax:9823)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of FSH_receptor -LRB- FSHR -RRB- in the neonatal porcine ovary and its regulation by flutamide .
20843821	0	FSH_receptor	132,144	androgen_receptor	54,71	FSH receptor	androgen receptor	2492	367	Gene	Gene	mRNA|compound|START_ENTITY correlate|nmod|mRNA correlate|nsubj|mRNA mRNA|amod|END_ENTITY	In human granulosa cells from small antral follicles , androgen_receptor mRNA and androgen levels in follicular fluid correlate with FSH_receptor mRNA .
7577719	0	FSH_receptor	85,97	androgen_receptor	29,46	FSH receptor	androgen receptor	102135198	367	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Ubiquitous expression of the androgen_receptor and testis-specific expression of the FSH_receptor in the cynomolgus_monkey -LRB- Macaca_fascicularis -RRB- revealed by a ribonuclease protection assay .
23211523	0	FSHb	33,37	b-catenin	0,9	FSHb	b-catenin	2488	1499	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	b-catenin regulates GnRH-induced FSHb gene expression .
16943576	0	FSHbeta	15,22	follistatin	73,84	FSHbeta	follistatin	25447(Tax:10116)	24373(Tax:10116)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Stimulation of FSHbeta transcription by blockade of endogenous pituitary follistatin production : Efficacy of adenoviral-delivered antisense RNA in the rat .
12145338	0	FSHbeta	39,46	rFSHbeta	48,56	FSHbeta	rFSHbeta	25447(Tax:10116)	25447(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Pituitary homeobox 1 activates the rat FSHbeta -LRB- rFSHbeta -RRB- gene through both direct and indirect interactions with the rFSHbeta gene promoter .
25315694	0	FSP27	14,19	AMPK	41,45	FSP27	AMPK	63924	5562	Gene	Gene	stability|compound|START_ENTITY Regulation|nmod|stability Regulation|nmod|END_ENTITY	Regulation of FSP27 protein stability by AMPK and HSC70 .
23265961	0	FST	38,41	follistatin	25,36	FST	follistatin	10468	10468	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Quantitative analysis of follistatin -LRB- FST -RRB- promoter methylation in peripheral blood of patients with polycystic_ovary_syndrome .
24718312	0	FT1	40,43	FLOWERING_LOCUS_T1	20,38	FT1	FLOWERING LOCUS T1	100838275	100838275	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of FLOWERING_LOCUS_T1 -LRB- FT1 -RRB- gene in brachypodium and wheat .
11145965	0	FTF	137,140	Hnf4alpha	173,182	FTF	Hnf4alpha	26424(Tax:10090)	15378(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The mouse fetoprotein_transcription_factor -LRB- FTF -RRB- gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs , and FTF in turn activates the Hnf3beta , Hnf4alpha , and Hnf1alpha gene promoters .
21573799	0	FTH1	0,4	Daxx	14,18	FTH1	Daxx	2495	1616	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis .
26871431	0	FTL	36,39	Ferritin_Light_Chain	14,34	FTL	Ferritin Light Chain	2512	2512	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Ferritin_Light_Chain -LRB- FTL -RRB- Is Elevated_in_Glioblastoma , and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway .
25303482	0	FTO	97,100	ALKBH5	124,130	FTO	ALKBH5	79068	54890	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Decreased_N -LRB- 6 -RRB- - methyladenosine in peripheral blood RNA from Diabetic Patients Is Associated with FTO Expression Rather than ALKBH5 .
25452335	0	FTO	39,42	ALKBH5	69,75	FTO	ALKBH5	79068	54890	Gene	Gene	demethylation|compound|START_ENTITY demethylation|nmod|m6A m6A|nmod|END_ENTITY	Meclofenamic_acid selectively inhibits FTO demethylation of m6A over ALKBH5 .
26711810	0	FTO	20,23	APOH	0,4	FTO	APOH	79068	350	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	APOH interacts with FTO to predispose to healthy thinness .
19008344	0	FTO	42,45	CDKAL1	47,53	FTO	CDKAL1	79068	54901	Gene	Gene	LOC387761|compound|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	FTO	79,82	CDKAL1	52,58	FTO	CDKAL1	79068	54901	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	FTO	79,82	CDKN2A/B	60,68	FTO	CDKN2A/B	79068	1029;1030	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
26218273	0	FTO	28,31	Demethylase	4,15	FTO	Demethylase	79068	8932	Gene	Gene	Activity|nmod|START_ENTITY Activity|amod|END_ENTITY	The Demethylase Activity of FTO -LRB- Fat_Mass_and_Obesity_Associated_Protein -RRB- Is Required for Preadipocyte Differentiation .
19008344	0	FTO	42,45	EXT2	70,74	FTO	EXT2	79068	2132	Gene	Gene	LOC387761|compound|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
23236435	0	FTO	38,41	Fat_mass_and_obesity_associated_gene	0,36	FTO	Fat mass and obesity associated gene	79068	79068	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fat_mass_and_obesity_associated_gene -LRB- FTO -RRB- expression is regulated negatively by the transcription factor Foxa2 .
19008344	0	FTO	42,45	HHEX	64,68	FTO	HHEX	79068	3087	Gene	Gene	LOC387761|compound|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	FTO	79,82	HHEX	46,50	FTO	HHEX	79068	3087	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19008344	0	FTO	42,45	IGF2BP2	76,83	FTO	IGF2BP2	79068	10644	Gene	Gene	LOC387761|compound|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	FTO	79,82	IGF2BP2	70,77	FTO	IGF2BP2	79068	10644	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
26018652	0	FTO	0,3	Insulin	13,20	FTO	Insulin	79068	3630	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Secretion Secretion|compound|END_ENTITY	FTO Inhibits Insulin Secretion and Promotes NF-kB Activation through Positively Regulating ROS Production in Pancreatic b cells .
26018652	0	FTO	0,3	Insulin	13,20	FTO	Insulin	79068	3630	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Secretion Secretion|compound|END_ENTITY	FTO Inhibits Insulin Secretion and Promotes NF-kB Activation through Positively Regulating ROS Production in Pancreatic b cells .
25501231	0	FTO	20,23	MC4R	25,29	FTO	MC4R	79068	4160	Gene	Gene	SLC30A8|compound|START_ENTITY SLC30A8|appos|END_ENTITY	Association between FTO , MC4R , SLC30A8 , and KCNQ1 gene variants and type 2 diabetes in Saudi population .
19008344	0	FTO	42,45	SLC30A8	55,62	FTO	SLC30A8	79068	169026	Gene	Gene	LOC387761|compound|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	FTO	79,82	SLC30A8	37,44	FTO	SLC30A8	79068	169026	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|compound|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	FTO	79,82	TCF2	84,88	FTO	TCF2	79068	6928	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
25151576	0	FTS	0,3	EGFR	68,72	FTS	EGFR	64400	1956	Gene	Gene	responsible|nsubj|START_ENTITY responsible|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells .
21777610	0	FTS	94,97	Fused_Toes_Homolog	99,117	FTS	Fused Toes Homolog	64400	64400	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Phosphorylation of threonine 190 is essential for nuclear localization and endocytosis of the FTS -LRB- Fused_Toes_Homolog -RRB- protein .
24971934	0	FTS	46,49	Fused_Toes_Homolog	26,44	FTS	Fused Toes Homolog	64400	64400	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	EGF-induced expression of Fused_Toes_Homolog -LRB- FTS -RRB- facilitates epithelial-mesenchymal transition and promotes cell migration in ME180 cervical cancer cells .
17098225	0	FTT-2	19,24	DAF-16	35,41	FTT-2	DAF-16	181348(Tax:6239)	172981(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis_elegans .
8887679	0	FTZ-F1	33,39	EDG84A	18,24	FTZ-F1	EDG84A	40045(Tax:7227)	40818(Tax:7227)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the EDG84A gene by FTZ-F1 during metamorphosis in Drosophila_melanogaster .
1545809	0	FTZ-F1	70,76	Embryonal_long_terminal_repeat-binding_protein	0,46	FTZ-F1	Embryonal long terminal repeat-binding protein	26423(Tax:10090)	26423(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Embryonal_long_terminal_repeat-binding_protein is a murine homolog of FTZ-F1 , a member of the steroid receptor superfamily .
25030436	0	FUBP1	39,44	Far_upstream_element-binding_protein_1	0,38	FUBP1	Far upstream element-binding protein 1	8880	8880	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Far_upstream_element-binding_protein_1 -LRB- FUBP1 -RRB- expression differs between human colorectal_cancer and non-cancerous tissue .
21284215	0	FUL	38,41	FRUITFULL	27,36	FUL	FRUITFULL	836212(Tax:3702)	836212(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Regulation pattern of the FRUITFULL -LRB- FUL -RRB- gene of Arabidopsis_thaliana -RSB- .
23867462	0	FUS	18,21	Fused_in_sarcoma	0,16	FUS	Fused in sarcoma	233908(Tax:10090)	233908(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Fused_in_sarcoma -LRB- FUS -RRB- protein lacking nuclear localization signal -LRB- NLS -RRB- and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic_mice .
26335776	0	FUS	0,3	HSP60	19,24	FUS	HSP60	2521	3329	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	FUS Interacts with HSP60 to Promote Mitochondrial Damage .
23620769	0	FUS	57,60	Protein_arginine_methyltransferase_1_and_8	0,42	FUS	Protein arginine methyltransferase 1 and 8	2521	3276;56341	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Protein_arginine_methyltransferase_1_and_8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo .
22526020	0	FUS	34,37	fused_in_sarcoma	16,32	FUS	fused in sarcoma	2521	2521	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Localization of fused_in_sarcoma -LRB- FUS -RRB- protein to the post-synaptic density in the brain .
22459602	0	FUS	7,10	protein_disulfide-isomerase	100,127	FUS	protein disulfide-isomerase	2521	64714	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Mutant FUS induces endoplasmic_reticulum_stress in amyotrophic_lateral_sclerosis and interacts with protein_disulfide-isomerase .
21909421	0	FUS/TLS	0,7	androgen_receptor	29,46	FUS/TLS	androgen receptor	2521	367	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	FUS/TLS is a co-activator of androgen_receptor in prostate_cancer cells .
18059478	0	FUSE	25,29	FIR	16,19	FUSE	FIR	2522	22827	Gene	Gene	binding|compound|START_ENTITY END_ENTITY|nmod|binding	Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition .
12819782	0	FUSE-binding_protein	18,38	tRNA_synthetase_cofactor_p38	52,80	FUSE-binding protein	tRNA synthetase cofactor p38	51886(Tax:10090)	26416(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of FUSE-binding_protein and c-myc by tRNA_synthetase_cofactor_p38 is required for lung cell differentiation .
10734235	0	FUSE_binding_protein	68,88	survival_motor_neuron	4,25	FUSE binding protein	survival motor neuron	8880	6606	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The survival_motor_neuron protein interacts with the transactivator FUSE_binding_protein from human fetal brain .
19134079	0	FUT1	53,57	alpha-1-fucosyltransferase	25,51	FUT1	alpha-1-fucosyltransferase	397138(Tax:9823)	397138(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation at the alpha-1-fucosyltransferase -LRB- FUT1 -RRB- gene in Asian wild_boar and Chinese and Western commercial pig breeds .
20570966	0	FUT2	22,26	Fucosyltransferase_2	0,20	FUT2	Fucosyltransferase 2	2524	2524	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Fucosyltransferase_2 -LRB- FUT2 -RRB- non-secretor status is associated with Crohn 's _ disease .
17655580	0	FUT2	64,68	fucosyltransferase_2	42,62	FUT2	fucosyltransferase 2	2524	2524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Systematic sequence analysis of the human fucosyltransferase_2 -LRB- FUT2 -RRB- gene identifies novel sequence variations and alleles .
23959823	0	FUT4	22,26	HSF1	0,4	FUT4	HSF1	2526	3297	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast_cancer cells .
24130780	0	FUT8	46,50	fucosyltransferase_8	24,44	FUT8	fucosyltransferase 8	2530	2530	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of microRNAs on fucosyltransferase_8 -LRB- FUT8 -RRB- expression in hepatocarcinoma cells .
22394599	0	FVIII	109,114	HLA-DRB1	143,151	FVIII	HLA-DRB1	2157	3123	Gene	Gene	applied|dobj|START_ENTITY applied|nmod|END_ENTITY	CD4 + T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1 * 1501 mice .
10410309	0	FVIII	56,61	VIII	50,54	FVIII	VIII	2157	1351	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of recombinant blood_coagulation factor VIII -LRB- FVIII -RRB- heavy and light chains and reconstitution of active form of FVIII .
12969981	0	FVIII	32,37	VWF	107,110	FVIII	VWF	2157	7450	Gene	Gene	domain|compound|START_ENTITY alanine_2201|nmod|domain Deletion|nmod|alanine_2201 results|nsubj|Deletion results|advcl|impairing impairing|xcomp|binding binding|nmod|END_ENTITY	Deletion of alanine_2201 in the FVIII C2 domain results in mild hemophilia_A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development .
12969981	0	FVIII	90,95	VWF	107,110	FVIII	VWF	2157	7450	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Deletion of alanine_2201 in the FVIII C2 domain results in mild hemophilia_A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development .
16985172	0	FVIII	13,18	VWF	0,3	FVIII	VWF	2157	7450	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors .
18549909	0	FVIII	41,46	VWF	12,15	FVIII	VWF	2157	7450	Gene	Gene	immunogenicity|nmod|START_ENTITY role|nmod|immunogenicity role|nmod|END_ENTITY	The role of VWF in the immunogenicity of FVIII .
21699629	0	FVIII	62,67	VWF	105,108	FVIII	VWF	2157	7450	Gene	Gene	Optivate|appos|START_ENTITY experience|nmod|Optivate experience|appos|END_ENTITY	Clinical experience with Optivate , high-purity factor_VIII -LRB- FVIII -RRB- product with von_Willebrand factor -LRB- VWF -RRB- in young children with haemophilia_A .
21725579	0	FVIII	79,84	VWF	60,63	FVIII	VWF	2157	7450	Gene	Gene	factor_VIII|appos|START_ENTITY concentrates|nsubj|factor_VIII diversity|parataxis|concentrates diversity|nmod|factor factor|appos|END_ENTITY	The pharmacokinetic diversity of two von_Willebrand factor -LRB- VWF -RRB- / factor_VIII -LRB- FVIII -RRB- concentrates in subjects with congenital_von_Willebrand_disease .
21726357	0	FVIII	59,64	VWF	55,58	FVIII	VWF	2157	100009165(Tax:9986)	Gene	Gene	ratio|nummod|START_ENTITY infusions|dep|ratio infusions|dep|impact impact|nmod|END_ENTITY	Repeated infusions of VWF/FVIII concentrate : impact of VWF : FVIII ratio on FVIII trough and peak levels in a rabbit model .
21726357	0	FVIII	74,79	VWF	55,58	FVIII	VWF	2157	100009165(Tax:9986)	Gene	Gene	trough|compound|START_ENTITY ratio|nmod|trough infusions|dep|ratio infusions|dep|impact impact|nmod|END_ENTITY	Repeated infusions of VWF/FVIII concentrate : impact of VWF : FVIII ratio on FVIII trough and peak levels in a rabbit model .
25035147	0	FVIII	0,5	VWF	21,24	FVIII	VWF	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	stabilization|compound|START_ENTITY stabilization|parataxis|do do|nsubj|D'D3 D'D3|compound|END_ENTITY	FVIII stabilization : VWF D'D3 will do .
25767894	0	FVIII	23,28	VWF	18,21	FVIII	VWF	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	ratio|nummod|START_ENTITY Utility|dep|ratio Utility|nmod|END_ENTITY	Utility of a high VWF : FVIII ratio in preventing FVIII accumulation : a study in VWF-deficient mice .
25767894	0	FVIII	49,54	VWF	18,21	FVIII	VWF	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	accumulation|compound|START_ENTITY ratio|nmod|accumulation Utility|dep|ratio Utility|nmod|END_ENTITY	Utility of a high VWF : FVIII ratio in preventing FVIII accumulation : a study in VWF-deficient mice .
25905473	0	FVIII	78,83	VWF	62,65	FVIII	VWF	2157	22371(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes .
17209060	0	FVIII	58,63	coagulation_factor_VIII	33,56	FVIII	coagulation factor VIII	2157	2157	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A sequence variation scan of the coagulation_factor_VIII -LRB- FVIII -RRB- structural gene and associations with plasma FVIII activity levels .
15213843	0	FVIII	18,23	factor_VIII	5,16	FVIII	factor VIII	2157	2157	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	High factor_VIII -LRB- FVIII -RRB- levels in venous_thromboembolism : role of unbound FVIII .
16643210	0	FVIII	93,98	factor_VIII	71,82	FVIII	factor VIII	2157	2157	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	A modified chromogenic assay for the measurement of very low levels of factor_VIII activity -LRB- FVIII : C -RRB- .
20682599	0	FVIII	98,103	vWF	31,34	FVIII	vWF	2157	7450	Gene	Gene	levels|nmod|START_ENTITY Polymorphisms|nmod|levels Polymorphisms|nmod|genes genes|compound|END_ENTITY	Polymorphisms and mutations in vWF and ADAMTS13 genes and their correlation with plasma levels of FVIII and vWF in patients with deep_venous_thrombosis .
2104761	0	FVIII	72,77	vWF	29,32	FVIII	vWF	2157	7450	Gene	Gene	factor_VIII|appos|START_ENTITY patient|nmod|factor_VIII deficiency|amod|patient defect|nmod|deficiency _|dobj|defect _|nsubj|_ _|appos|END_ENTITY	A new von_Willebrand_factor _ -LRB- vWF -RRB- _ defect in a patient with factor_VIII -LRB- FVIII -RRB- deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF .
25623511	0	FXI	51,54	factor_XI	40,49	FXI	factor XI	2160	2160	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Bleeding phenotype and correlation with factor_XI -LRB- FXI -RRB- activity in congenital_FXI_deficiency : results of a retrospective study from a single centre .
24816001	0	FXN	44,47	Friedreich_ataxia	9,26	FXN	Friedreich ataxia	2395	2395	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Atypical Friedreich_ataxia in patients with FXN p.R165P point mutation or comorbid hemochromatosis .
21642744	0	FXR	44,47	Aldo-keto_reductase_1B7	0,23	FXR	Aldo-keto reductase 1B7	20186(Tax:10090)	11997(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Aldo-keto_reductase_1B7 is a target gene of FXR and regulates lipid and glucose homeostasis .
19118524	0	FXR	70,73	C-reactive_protein	37,55	FXR	C-reactive protein	9971	1401	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of interleukin-6-induced C-reactive_protein expression by FXR agonists .
25138215	0	FXR	85,88	Farnesoid_X_Receptor	63,83	FXR	Farnesoid X Receptor	20186(Tax:10090)	20186(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of the Intestinal Nuclear Bile_Acid Farnesoid_X_Receptor -LRB- FXR -RRB- by the caudal-related_Homeobox_2 -LRB- CDX2 -RRB- .
18769028	0	FXR	54,57	GLUT4	82,87	FXR	GLUT4	20186(Tax:10090)	20528(Tax:10090)	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|compound|END_ENTITY	Farnesoid_X_receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter .
26501563	0	FXR	24,27	MafG	0,4	FXR	MafG	9971	4097	Gene	Gene	Target|nmod|START_ENTITY END_ENTITY|appos|Target	MafG , A Novel Target of FXR that Regulates Bile_Acid Homeostasis .
21504366	0	FXR	67,70	Nrf2	0,4	FXR	Nrf2	9971	4780	Gene	Gene	competing|nmod|START_ENTITY inhibits|advcl|competing inhibits|nsubj|END_ENTITY	Nrf2 inhibits LXRa-dependent hepatic lipogenesis by competing with FXR for acetylase binding .
15521018	0	FXR	74,77	SHP	21,24	FXR	SHP	60351(Tax:10116)	117274(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver_fibrosis .
18842595	0	FXR	74,77	SHP	92,95	FXR	SHP	20186(Tax:10090)	23957(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	The p300 acetylase is critical for ligand-activated farnesoid_X_receptor -LRB- FXR -RRB- induction of SHP .
24498423	0	FXR	6,9	SHP	20,23	FXR	SHP	9971	8431	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Human FXR regulates SHP expression through direct binding to an LRH-1 binding site , independent of an IR-1 and LRH-1 .
12454263	0	FXR	60,63	apoE	49,53	FXR	apoE	9971	348	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors .
25138215	0	FXR	85,88	caudal-related_Homeobox_2	97,122	FXR	caudal-related Homeobox 2	20186(Tax:10090)	12591(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of the Intestinal Nuclear Bile_Acid Farnesoid_X_Receptor -LRB- FXR -RRB- by the caudal-related_Homeobox_2 -LRB- CDX2 -RRB- .
23507574	0	FXR	38,41	chemerin	18,26	FXR	chemerin	20186(Tax:10090)	71660(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic_steatohepatitis .
23507574	0	FXR	38,41	chemerin	18,26	FXR	chemerin	20186(Tax:10090)	71660(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic_steatohepatitis .
12519787	0	FXR	78,81	farnesoid_X_receptor	56,76	FXR	farnesoid X receptor	9971	9971	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Retinoid_X_receptor -LRB- RXR -RRB- agonist-induced antagonism of farnesoid_X_receptor -LRB- FXR -RRB- activity due to absence of coactivator recruitment and decreased DNA binding .
14733360	0	FXR	47,50	farnesoid_X_receptor	25,45	FXR	farnesoid X receptor	9971	9971	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Ligand-binding domain of farnesoid_X_receptor -LRB- FXR -RRB- had the highest sensitivity and activity among FXR variants in a fluorescence-based assay .
23073079	0	FXR	54,57	farnesoid_X_receptor	32,52	FXR	farnesoid X receptor	9971	9971	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The significance of the nuclear farnesoid_X_receptor -LRB- FXR -RRB- in b cell function .
24875360	0	FXR	36,39	farnesoid_X_receptor	14,34	FXR	farnesoid X receptor	20186(Tax:10090)	20186(Tax:10090)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of farnesoid_X_receptor -LRB- FXR -RRB- protects against fructose-induced liver_steatosis via inflammatory inhibition and ADRP reduction .
25156247	0	FXR	103,106	farnesoid_X_receptor	22,42	FXR	farnesoid X receptor	20186(Tax:10090)	20186(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|nmod|END_ENTITY	Protective effects of farnesoid_X_receptor -LRB- FXR -RRB- on hepatic_lipid_accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal .
26337021	0	FXR	124,127	farnesoid_X_receptor	102,122	FXR	farnesoid X receptor	9971	9971	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery and SAR study of 3 - -LRB- tert-butyl -RRB- -4 - hydroxyphenyl_benzoate and benzamide derivatives as novel farnesoid_X_receptor -LRB- FXR -RRB- antagonists .
15604525	0	FXR	35,38	fibrinogen	47,57	FXR	fibrinogen	9971	2244	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|dobj|expression expression|compound|END_ENTITY	Activation of the nuclear receptor FXR induces fibrinogen expression : a new role for bile_acid signaling .
20060466	0	FXR	21,24	insulin	35,42	FXR	insulin	9971	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	The bile_acid sensor FXR regulates insulin transcription and secretion .
25810294	0	FXR	59,62	mir33	16,21	FXR	mir33	9971	407039	Gene	Gene	Links|dobj|START_ENTITY Links|nsubj|END_ENTITY	SREBF2-Embedded mir33 Links the Nuclear Bile Acid Receptor FXR to Cholesterol and Lipoprotein Metabolism .
15548538	0	FXR1P	26,31	tumor_necrosis_factor	67,88	FXR1P	tumor necrosis factor	14359(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor_necrosis_factor expression at the post-transcriptional level .
22965940	0	FXYD5	154,159	Dysadherin	161,171	FXYD5	Dysadherin	53827	53827	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Let-7a down-regulation plays a role_in_thyroid_neoplasias of follicular histotype affecting cell adhesion and migration through its ability to target the FXYD5 -LRB- Dysadherin -RRB- gene .
18455306	0	FXYD6	85,90	FXYD_domain_containing_ion_transport_regulator_6	35,83	FXYD6	FXYD domain containing ion transport regulator 6	53826	53826	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A genetic association study of the FXYD_domain_containing_ion_transport_regulator_6 -LRB- FXYD6 -RRB- gene , encoding phosphohippolin , in susceptibility to schizophrenia in a Japanese population .
17357072	0	FXYD6	91,96	phosphohippolin	112,127	FXYD6	phosphohippolin	53826	53826	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene , encoding phosphohippolin , in susceptibility to schizophrenia .
18455306	0	FXYD_domain_containing_ion_transport_regulator_6	35,83	FXYD6	85,90	FXYD domain containing ion transport regulator 6	FXYD6	53826	53826	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A genetic association study of the FXYD_domain_containing_ion_transport_regulator_6 -LRB- FXYD6 -RRB- gene , encoding phosphohippolin , in susceptibility to schizophrenia in a Japanese population .
20702967	0	FXa	29,32	factor_Xa	18,27	FXa	factor Xa	2159	2159	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	-LSB- Do orally active factor_Xa -LRB- FXa -RRB- inhibitors have potential as innovative new anticoagulants ?
9423800	0	FXa	62,65	tissue_factor_pathway_inhibitor	6,37	FXa	tissue factor pathway inhibitor	2159	7035	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Human tissue_factor_pathway_inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface .
9207119	0	FYB	34,37	FYN	49,52	FYB	FYN	2533	2534	Gene	Gene	START_ENTITY|ccomp|binds binds|dobj|END_ENTITY	Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing_leukocyte_protein_76 and modulates interleukin_2 production .
10640723	0	FYB	48,51	SLAP-130	39,47	FYB	SLAP-130	2533	2533	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Cutting edge : a novel function for the SLAP-130 / FYB adapter protein in beta_1_integrin signaling and T lymphocyte migration .
24970799	0	FYN	50,53	COX2	33,37	FYN	COX2	2534	4513	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|compound|END_ENTITY	Post-translational regulation of COX2 activity by FYN in prostate_cancer cells .
9207119	0	FYN	49,52	FYB	34,37	FYN	FYB	2534	2533	Gene	Gene	binds|dobj|START_ENTITY END_ENTITY|ccomp|binds	Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing_leukocyte_protein_76 and modulates interleukin_2 production .
26786295	0	FYN	46,49	KLF5	0,4	FYN	KLF5	14360(Tax:10090)	12224(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	KLF5 promotes cell migration by up-regulating FYN in bladder_cancer cells .
11743650	0	FZD10	30,35	Frizzled-10	17,28	FZD10	Frizzled-10	11211	11211	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of Frizzled-10 -LRB- FZD10 -RRB- by beta-estradiol in MCF-7 cells and by retinoic_acid in NT2 cells .
16707163	0	FZD3	76,80	Frizzled_homolog_3	51,69	FZD3	Frizzled homolog 3	7976	7976	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation of genetic association between human Frizzled_homolog_3 gene -LRB- FZD3 -RRB- and schizophrenia : results in a Korean population and evidence from meta-analysis .
14642436	0	FZD3	22,26	frizzled-3	10,20	FZD3	frizzled-3	7976	7976	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human frizzled-3 -LRB- FZD3 -RRB- gene on chromosome 8p21 , a receptor gene for Wnt ligands , is associated with the susceptibility to schizophrenia .
15657645	0	FZD3	37,41	frizzled-3	25,35	FZD3	frizzled-3	7976	7976	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of the frizzled-3 -LRB- FZD3 -RRB- gene with schizophrenia and mood_disorders .
15274031	0	FZD3	46,50	frizzled_3	34,44	FZD3	frizzled 3	7976	7976	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Positive association of the human frizzled_3 -LRB- FZD3 -RRB- gene haplotype with schizophrenia in Chinese Han population .
20713528	0	FZD4	0,4	ERG	22,25	FZD4	ERG	8322	2078	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate_cancer cells .
14507768	0	FZD4	17,21	Frizzled_4	0,10	FZD4	Frizzled 4	8322	8322	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frizzled_4 gene -LRB- FZD4 -RRB- mutations in patients with familial_exudative_vitreoretinopathy with variable expressivity .
12857724	0	FZD5	81,85	LRP6	88,92	FZD5	LRP6	317674(Tax:10116)	312781(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Functional characterization of WNT7A signaling in PC12 cells : interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins .
25240054	0	FZD5	39,43	Wnt5a	18,23	FZD5	Wnt5a	7855	7474	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Monocyte-secreted Wnt5a interacts with FZD5 in microvascular endothelial cells and induces angiogenesis through tissue factor signaling .
11408930	0	FZD7	29,33	Frizzled-7	17,27	FZD7	Frizzled-7	8324	8324	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of Frizzled-7 -LRB- FZD7 -RRB- in human gastric_cancer .
25619565	0	FZD8	52,56	miR-375	0,7	FZD8	miR-375	364754(Tax:10116)	100314263(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts .
19129509	0	FZR1	20,24	CDC14B	0,6	FZR1	CDC14B	56371(Tax:10090)	218294(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	CDC14B acts through FZR1 -LRB- CDH1 -RRB- to prevent meiotic maturation of mouse oocytes .
9300465	0	FaRPs	68,73	FMRF_amide-related_peptides	39,66	FaRPs	FMRF amide-related peptides	64111	64111	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Physiological effects of platyhelminth FMRF_amide-related_peptides -LRB- FaRPs -RRB- on the motility of the monogenean Diclidophora merlangi .
7980835	0	FaRPs	56,61	FMRFamide-related_peptides	28,54	FaRPs	FMRFamide-related peptides	64111	64111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of mRNA encoding FMRFamide-related_peptides -LRB- FaRPs -RRB- in the nervous system of Helix aspersa .
9935015	0	Fab	13,16	CD11b	47,52	Fab	CD11b	2187	3684	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Chimeric 7E3 Fab -LRB- ReoPro -RRB- decreases detectable CD11b on neutrophils from patients undergoing coronary angioplasty .
9606729	0	Fab	75,78	bradykinin	53,63	Fab	bradykinin	2187	3827	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	NMR investigations of recombinant 15N/13C/2H-labeled bradykinin bound to a Fab mimic of the B2_receptor .
15169664	0	Fab	58,61	gamma-seminoprotein	76,95	Fab	gamma-seminoprotein	2187	354	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Prokaryotic expression and bioactivity identification of Fab against human gamma-seminoprotein -RSB- .
3201756	0	Fab	111,114	neuraminidase	73,86	Fab	neuraminidase	2187	4758	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Crystallization and preliminary X-ray analysis of type B influenza virus neuraminidase complexed with antibody Fab fragments .
4045562	0	Fab	51,54	p97	63,66	Fab	p97	2187	4241	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Melanoma localization in nude_mice with monoclonal Fab against p97 .
17725301	0	Fab	47,50	prostate_specific_membrane_antigen	68,102	Fab	prostate specific membrane antigen	2187	2346	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Screening and characterization of human phage Fab antibody gene to prostate_specific_membrane_antigen -RSB- .
8985187	0	Fab-7	4,9	bithorax_complex	25,41	Fab-7	bithorax complex	5657585	42034(Tax:7227)	Gene	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	The Fab-7 element of the bithorax_complex attenuates enhancer-promoter interactions in the Drosophila embryo .
11889142	0	Fab1p	123,128	Vac14p	82,88	Fab1p	Vac14p	850574(Tax:4932)	851102(Tax:4932)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Osmotic stress-induced increase of phosphatidylinositol_3 ,5 - bisphosphate requires Vac14p , an activator of the lipid kinase Fab1p .
10721717	0	Faciogenital_Dysplasia	71,93	FGD1	95,99	Faciogenital Dysplasia	FGD1	14163(Tax:10090)	14163(Tax:10090)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Isolation , characterization , and mapping of the mouse Fgd3 gene , a new Faciogenital_Dysplasia -LRB- FGD1 ; Aarskog Syndrome -RRB- gene homologue .
26181365	0	Factor-H	67,75	BAPKO_0422	44,54	Factor-H	BAPKO_0422	3075	4227740(Tax:390236)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The Borrelia_afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning b-barrel .
10747989	0	Factor_H	0,8	bone_sialoprotein	20,37	Factor H	bone sialoprotein	3075	3381	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Factor_H binding to bone_sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack .
25855355	0	Factor_H-Related_Protein_5	0,26	Pentraxin_3	42,53	Factor H-Related Protein 5	Pentraxin 3	81494	5806	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	Factor_H-Related_Protein_5 Interacts with Pentraxin_3 and the Extracellular Matrix and Modulates Complement Activation .
11187883	0	Factor_VIII	0,11	factor_VIII	54,65	Factor VIII	factor VIII	2157	2157	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|activity activity|nmod|END_ENTITY	Factor_VIII inhibitor with catalytic activity towards factor_VIII .
22908929	0	Factor_VIII	0,11	von_Willebrand_factor	24,45	Factor VIII	von Willebrand factor	2157	7450	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|parataxis|makes makes|nsubj|END_ENTITY	Factor_VIII inhibitors : von_Willebrand_factor makes a difference in vitro and in vivo .
17572893	0	Factor_V_Leiden	0,15	prothrombin	28,39	Factor V Leiden	prothrombin	2153	2147	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Factor_V_Leiden and G20210A prothrombin mutations in patients with recurrent_pregnancy_loss : data from the southeast of Turkey .
20228268	0	Factor_XII	0,10	ERK1/2	22,28	Factor XII	ERK1/2	58992(Tax:10090)	26417;26413	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Factor_XII stimulates ERK1/2 and Akt through uPAR , integrins , and the EGFR to initiate angiogenesis .
6411770	0	Factor_XII	41,51	Hageman_factor	25,39	Factor XII	Hageman factor	306761(Tax:10116)	306761(Tax:10116)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and release of Hageman_factor -LRB- Factor_XII -RRB- by the isolated perfused rat liver .
20228268	0	Factor_XII	0,10	uPAR	45,49	Factor XII	uPAR	58992(Tax:10090)	18793(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Factor_XII stimulates ERK1/2 and Akt through uPAR , integrins , and the EGFR to initiate angiogenesis .
19150337	0	Factor_Xa	54,63	Platelet_Factor_4	15,32	Factor Xa	Platelet Factor 4	2159	5196	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Dual effect of Platelet_Factor_4 on the activities of Factor_Xa .
6439669	0	Factor_Xa	115,124	prothrombin	100,111	Factor Xa	prothrombin	2159	2147	Gene	Gene	accompanying|nmod|START_ENTITY accompanying|dobj|proteolysis proteolysis|nmod|END_ENTITY	Origin of a fluorescence increase accompanying the limited proteolysis of fluorescein-labeled human prothrombin by Factor_Xa .
22247769	0	Factor_Xa	0,9	thrombin	79,87	Factor Xa	thrombin	2159	2147	Gene	Gene	generation|compound|START_ENTITY generation|dep|discriminator discriminator|nmod|evaluation evaluation|amod|END_ENTITY	Factor_Xa generation by computational modeling : an additional discriminator to thrombin generation evaluation .
9716152	0	Factor_Xa	0,9	tissue_factor_pathway_inhibitor	22,53	Factor Xa	tissue factor pathway inhibitor	2159	7035	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Factor_Xa cleavage of tissue_factor_pathway_inhibitor is associated with loss of anticoagulant activity .
26390980	0	Factor_b	13,21	Runx2	87,92	Factor b	Runx2	14962(Tax:10090)	12393(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Stabilization Stabilization|nmod|END_ENTITY	Core Binding Factor_b of Osteoblasts Maintains Cortical Bone Mass Via Stabilization of Runx2 in Mice .
21826159	0	Faded	15,20	fe	22,24	Faded	fe	14150(Tax:10090)	14150(Tax:10090)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Mapping of the Faded -LRB- fe -RRB- Gene to a Region between D10mit191 and D10mit44 on Mouse Chromosome 10 .
7766995	0	Fadk	38,42	focal_adhesion_kinase	15,36	Fadk	focal adhesion kinase	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the focal_adhesion_kinase -LRB- Fadk -RRB- gene to mouse chromosome 15 and human chromosome 8 .
26032498	0	Fak	50,53	Spondin_1	0,9	Fak	Spondin 1	5747	10418	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Spondin_1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma .
23241886	0	Fam65b	0,6	FOXO1	42,47	Fam65b	FOXO1	9750	2308	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration .
15530918	0	Familial_Hypercholesterolemia	98,127	PCSK9	64,69	Familial Hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|genes genes|compound|END_ENTITY	No genetic linkage or molecular evidence for involvement of the PCSK9 , ARH or CYP7A1 genes in the Familial_Hypercholesterolemia phenotype in a sample of Danish families without pathogenic mutations in the LDL_receptor and apoB genes .
26632531	0	Familial_Hypercholesterolemia	18,47	PCSK9	100,105	Familial Hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	Lipoprotein|nmod|START_ENTITY Lipoprotein|dep|Kexin_Type_9 Kexin_Type_9|dep|Mutations Mutations|appos|END_ENTITY	Lipoprotein -LRB- a -RRB- in Familial_Hypercholesterolemia With Proprotein_Convertase_Subtilisin / Kexin_Type_9 -LRB- PCSK9 -RRB- Gain-of-Function Mutations .
26966528	0	Familial_Mediterranean_Fever	72,100	ERAP-1	59,65	Familial Mediterranean Fever	ERAP-1	4210	51752	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association of endoplasmic_reticulum_aminopeptidase-1 -LRB- ERAP-1 -RRB- with Familial_Mediterranean_Fever -LRB- FMF -RRB- .
26966528	0	Familial_Mediterranean_Fever	72,100	endoplasmic_reticulum_aminopeptidase-1	19,57	Familial Mediterranean Fever	endoplasmic reticulum aminopeptidase-1	4210	51752	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of endoplasmic_reticulum_aminopeptidase-1 -LRB- ERAP-1 -RRB- with Familial_Mediterranean_Fever -LRB- FMF -RRB- .
26797144	0	Fan1	30,34	Fancd2	14,20	Fan1	Fancd2	330554(Tax:10090)	211651(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability .
18279715	0	Fanca	55,60	CXCR4	0,5	Fanca	CXCR4	14087(Tax:10090)	12767(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	CXCR4 induction in hematopoietic progenitor cells from Fanca -LRB- - / - -RRB- , - c -LRB- - / - -RRB- , and - d2 -LRB- - / - -RRB- mice .
26797144	0	Fancd2	14,20	Fan1	30,34	Fancd2	Fan1	211651(Tax:10090)	330554(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability .
24349332	0	Fanconi_anemia_complementation_group_a_protein	6,52	FEN1	101,105	Fanconi anemia complementation group a protein	FEN1	2175	2237	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	Human Fanconi_anemia_complementation_group_a_protein stimulates the 5 ' flap endonuclease activity of FEN1 .
9721219	0	Fanconi_anemia_group_A	34,56	FAA	58,61	Fanconi anemia group A	FAA	2184	2184	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fine exon-intron structure of the Fanconi_anemia_group_A -LRB- FAA -RRB- gene and characterization of two genomic deletions .
20978819	0	Fank1	0,5	Jab1	21,25	Fank1	Jab1	92565	10987	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway .
25030436	0	Far_upstream_element-binding_protein_1	0,38	FUBP1	39,44	Far upstream element-binding protein 1	FUBP1	8880	8880	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Far_upstream_element-binding_protein_1 -LRB- FUBP1 -RRB- expression differs between human colorectal_cancer and non-cancerous tissue .
25138215	0	Farnesoid_X_Receptor	63,83	FXR	85,88	Farnesoid X Receptor	FXR	20186(Tax:10090)	20186(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Transcriptional Regulation of the Intestinal Nuclear Bile_Acid Farnesoid_X_Receptor -LRB- FXR -RRB- by the caudal-related_Homeobox_2 -LRB- CDX2 -RRB- .
25138215	0	Farnesoid_X_Receptor	63,83	caudal-related_Homeobox_2	97,122	Farnesoid X Receptor	caudal-related Homeobox 2	20186(Tax:10090)	12591(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of the Intestinal Nuclear Bile_Acid Farnesoid_X_Receptor -LRB- FXR -RRB- by the caudal-related_Homeobox_2 -LRB- CDX2 -RRB- .
18769028	0	Farnesoid_X_receptor	0,20	GLUT4	29,34	Farnesoid X receptor	GLUT4	20186(Tax:10090)	20528(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Farnesoid_X_receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter .
18769028	0	Farnesoid_X_receptor	0,20	GLUT4	82,87	Farnesoid X receptor	GLUT4	20186(Tax:10090)	20528(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|element element|nmod|promoter promoter|compound|END_ENTITY	Farnesoid_X_receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter .
21499302	0	Farnesoid_X_receptor	0,20	HER2	108,112	Farnesoid X receptor	HER2	9971	2064	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	Farnesoid_X_receptor inhibits tamoxifen-resistant MCF-7 breast_cancer cell growth through downregulation of HER2 expression .
14527955	0	Farnesoid_X_receptor	0,20	MDR3	70,74	Farnesoid X receptor	MDR3	9971	5244	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	Farnesoid_X_receptor activates transcription of the phospholipid pump MDR3 .
23530060	0	Farnesoid_X_receptor	0,20	carbohydrate_response_element_binding_protein	62,107	Farnesoid X receptor	carbohydrate response element binding protein	9971	51085	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Farnesoid_X_receptor inhibits the transcriptional activity of carbohydrate_response_element_binding_protein in human hepatocytes .
21296199	0	Farnesoid_X_receptor	0,20	constitutive_androstane_receptor	32,64	Farnesoid X receptor	constitutive androstane receptor	9971	9970	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	Farnesoid_X_receptor suppresses constitutive_androstane_receptor activity at the multidrug_resistance_protein-4 promoter .
15342685	0	Farnesoid_X_receptor	0,20	hepatic_lipase	31,45	Farnesoid X receptor	hepatic lipase	9971	3990	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Farnesoid_X_receptor represses hepatic_lipase gene expression .
11710833	0	Fas-L	19,24	ribozyme	44,52	Fas-L	ribozyme	14103(Tax:10090)	356	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Down-regulation of Fas-L in glioma cells by ribozyme reduces cell apoptosis , tumour-infiltrating cells , and liver_damage but accelerates tumour formation in nude_mice .
23828893	0	Fas-associated_death_domain-containing_protein	8,54	FADD	56,60	Fas-associated death domain-containing protein	FADD	14082(Tax:10090)	14082(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Fas-associated_death_domain-containing_protein -LRB- FADD -RRB- phosphorylation in regulating glucose homeostasis : from proteomic discovery to physiological validation .
24058479	0	Fas-associated_death_domain-containing_protein	14,60	FADD	62,66	Fas-associated death domain-containing protein	FADD	14082(Tax:10090)	14082(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of Fas-associated_death_domain-containing_protein -LRB- FADD -RRB- protects against myocardial_ischemia / reperfusion injury in a heart_failure mouse model .
11765224	0	Fas-associated_death_domain-like_interleukin-1beta-converting_enzyme	14,82	FLIP	111,115	Fas-associated death domain-like interleukin-1beta-converting enzyme	FLIP	841	8837	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of Fas-associated_death_domain-like_interleukin-1beta-converting_enzyme -LRB- FLICE -RRB- inhibitory protein -LRB- FLIP -RRB- in human articular chondrocytes : possible contribution to the resistance to Fas-mediated death of in vitro cultured human articular chondrocytes .
18790738	0	Fas-associated_factor-1	64,87	Aurora-A	32,40	Fas-associated factor-1	Aurora-A	11124	6790	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative feedback regulation of Aurora-A via phosphorylation of Fas-associated_factor-1 .
17046979	0	Fas-associated_factor_1	0,23	PYRIN-containing_Apaf-1-like_protein_1	51,89	Fas-associated factor 1	PYRIN-containing Apaf-1-like protein 1	11124	114548	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Fas-associated_factor_1 is a negative regulator of PYRIN-containing_Apaf-1-like_protein_1 .
23293021	0	Fas-associated_factor_1	11,34	valosin-containing_protein	47,73	Fas-associated factor 1	valosin-containing protein	11124	7415	Gene	Gene	START_ENTITY|nmod|proteins proteins|amod|END_ENTITY	Complex of Fas-associated_factor_1 -LRB- FAF1 -RRB- with valosin-containing_protein -LRB- VCP -RRB- - Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation -LRB- ERAD -RRB- .
10544233	0	Fas-associated_phosphatase-1	26,54	FAP-1	56,61	Fas-associated phosphatase-1	FAP-1	5783	5783	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Functional interaction of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- with p75 -LRB- NTR -RRB- and their effect on NF-kappaB activation .
9665752	0	Fas-associated_phosphatase-1	19,47	FAP-1	49,54	Fas-associated phosphatase-1	FAP-1	5783	5783	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- in interleukin-2-activated T cells .
11106428	0	Fas-associated_phosphatase-1	49,77	IkappaBalpha	18,30	Fas-associated phosphatase-1	IkappaBalpha	5783	4792	Gene	Gene	substrate|nmod|START_ENTITY Identification|nmod|substrate Identification|nmod|END_ENTITY	Identification of IkappaBalpha as a substrate of Fas-associated_phosphatase-1 .
12436199	0	Fas-associated_phosphatase-1	30,58	JNK3	100,104	Fas-associated phosphatase-1	JNK3	5783	5602	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Head-to-head juxtaposition of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- and c-Jun_NH2-terminal_kinase_3 -LRB- JNK3 -RRB- genes : genomic structure and seven polymorphisms of the FAP-1 gene .
10544233	0	Fas-associated_phosphatase-1	26,54	p75	68,71	Fas-associated phosphatase-1	p75	5783	7133	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- with p75 -LRB- NTR -RRB- and their effect on NF-kappaB activation .
14662196	0	Fas-ligand	27,37	CD152	20,25	Fas-ligand	CD152	356	1493	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Evaluation of CD25 , CD152 , Fas-ligand expression in the adenoids of allergic and non-allergic children : a pilot study .
14662196	0	Fas-ligand	27,37	CD25	14,18	Fas-ligand	CD25	356	3559	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Evaluation of CD25 , CD152 , Fas-ligand expression in the adenoids of allergic and non-allergic children : a pilot study .
23889933	0	Fas2	65,69	Mef2	25,29	Fas2	Mef2	31364(Tax:7227)	36032(Tax:7227)	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	The transcription factor Mef2 links the Drosophila core clock to Fas2 , neuronal morphology , and circadian behavior .
23864680	0	FasII	92,97	Adf-1	36,41	FasII	Adf-1	31364(Tax:7227)	47082(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The Drosophila transcription factor Adf-1 -LRB- nalyot -RRB- regulates dendrite growth by controlling FasII and Staufen expression downstream of CaMKII and neural activity .
17290285	0	FasL	17,21	ADAM10	0,6	FasL	ADAM10	356	102	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death .
8996241	0	FasL	98,102	CD4	34,37	FasL	CD4	356	920	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|apoptosis apoptosis|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Macrophage-dependent apoptosis of CD4 + T lymphocytes from HIV-infected individuals is mediated by FasL and tumor_necrosis_factor .
11464860	0	FasL	47,51	CD95	25,29	FasL	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Expression of Fas -LRB- APO-1 / CD95 -RRB- and Fas_ligand -LRB- FasL -RRB- in human neuroblastoma .
23152729	0	FasL	65,69	CD95	43,47	FasL	CD95	356	355	Gene	Gene	Fas|appos|START_ENTITY Fas|appos|END_ENTITY	Prognostic impact of apoptosis marker Fas -LRB- CD95 -RRB- and its ligand -LRB- FasL -RRB- on bladder_cancer in Egypt : study of the effect of schistosomiasis .
23821188	0	FasL	25,29	CD95L	31,36	FasL	CD95L	14103(Tax:10090)	14103(Tax:10090)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Age-dependent changes in FasL -LRB- CD95L -RRB- modulate macrophage function in a model of age-related macular_degeneration .
9730890	0	FasL	41,45	CD95_ligand	28,39	FasL	CD95 ligand	356	356	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Antiinflammatory effects of CD95_ligand -LRB- FasL -RRB- - induced apoptosis .
21088216	0	FasL	23,27	CTLA-4	15,21	FasL	CTLA-4	356	1493	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	CD40 FasL and CTLA-4 FasL fusion proteins induce apoptosis in malignant cell lines by dual signaling .
22252758	0	FasL	35,39	Fas_Ligand	23,33	FasL	Fas Ligand	356	356	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of Fas_Ligand -LRB- FasL -RRB- in the lower airways of patients with fibrotic interstitial_lung_diseases -LRB- ILDs -RRB- .
10571510	0	FasL	30,34	Fas_ligand	18,28	FasL	Fas ligand	356	356	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Fas_ligand -LRB- FasL -RRB- during malignant transformation in the large bowel and in Barrett 's metaplasia of the esophagus .
15387375	0	FasL	45,49	Fas_ligand	33,43	FasL	Fas ligand	14103(Tax:10090)	14103(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Essential role for hematopoietic Fas_ligand -LRB- FasL -RRB- in the suppression of melanoma lung metastasis revealed in bone marrow chimeric mice .
20013612	0	FasL	12,16	Fas_ligand	0,10	FasL	Fas ligand	356	356	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fas_ligand -LRB- FasL , Apo-1L / CD95L -RRB- expression and clinical outcome in papillary_microcarcinoma and papillary_thyroid_carcinomas with diameter smaller than 1.5 centimeters .
9284765	0	FasL	49,53	Fas_ligand	37,47	FasL	Fas ligand	356	356	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the apoptosis-inducing Fas_ligand -LRB- FasL -RRB- in human first and third trimester placenta and choriocarcinoma cells .
9566799	0	FasL	29,33	Fas_ligand	17,27	FasL	Fas ligand	356	356	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Up-regulation of Fas_ligand -LRB- FasL -RRB- mRNA expression in peripheral blood mononuclear cells -LRB- PBMC -RRB- after major surgery .
10556800	0	FasL	0,4	IL-2	28,32	FasL	IL-2	356	3558	Gene	Gene	promoter|amod|START_ENTITY promoter|acl|activation activation|nmod|END_ENTITY	FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3 .
24335017	0	FasL	38,42	MiR-21	10,16	FasL	MiR-21	356	406991	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Impact of MiR-21 on the expression of FasL in the presence of TGF-b1 .
10556800	0	FasL	0,4	SP1	41,44	FasL	SP1	356	6667	Gene	Gene	promoter|amod|START_ENTITY promoter|acl|activation activation|nmod|END_ENTITY	FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3 .
15694838	0	FasL	20,24	Sp1	45,48	FasL	Sp1	356	6667	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	p21 -LRB- Waf1/Cip1 -RRB- and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli .
18676775	0	FasL	18,22	Thy1	0,4	FasL	Thy1	356	7070	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Thy1 up-regulates FasL expression in lung myofibroblasts via Src family kinases .
22907769	0	FasL	17,21	miR-21	0,6	FasL	miR-21	356	406991	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	miR-21 represses FasL in microglia and protects against microglia-mediated neuronal cell death following hypoxia/ischemia .
23177026	0	FasL	160,164	miR-21	105,111	FasL	miR-21	356	406991	Gene	Gene	targeting|dobj|START_ENTITY chemoresistance|advcl|targeting confers|xcomp|chemoresistance confers|nsubj|expression expression|amod|END_ENTITY	The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic_cancer , and miR-21 expression confers chemoresistance by targeting FasL .
15858021	0	FasL	195,199	tumor_necrosis_factor_receptor_1	202,234	FasL	tumor necrosis factor receptor 1	14103(Tax:10090)	21937(Tax:10090)	Gene	Gene	Fas|dep|START_ENTITY Fas|dep|END_ENTITY	The Nef-mediated AIDS-like_disease of CD4C/human immunodeficiency virus transgenic_mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas - , FasL - , tumor_necrosis_factor_receptor_1 - , or interleukin-1beta-converting_enzyme-deficient or Bcl2-expressing transgenic_mice .
17301382	0	Fas_Antigen	14,25	CD95	27,31	Fas Antigen	CD95	355	355	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Fas_Antigen -LRB- CD95 -RRB- on Human Leukemic Cells and Assessment of Apoptosis on Fas + and Fas-Samples by Flowcytometry Method .
18409287	0	Fas_Ligand	48,58	CD8	44,47	Fas Ligand	CD8	356	925	Gene	Gene	cytotoxic|compound|START_ENTITY cytotoxic|compound|END_ENTITY	-LSB- Cigarette smoking results in the number of CD8 + Fas_Ligand + T cytotoxic lymphocytes in bronchoalveolar lavage -LRB- BAL -RRB- fluid of patients with idiopathic_pulmonary_fibrosis -LRB- IPF -RRB- -RSB- .
26583143	0	Fas_Ligand	22,32	Calreticulin	0,12	Fas Ligand	Calreticulin	356	811	Gene	Gene	Binds|nmod|START_ENTITY Binds|nsubj|END_ENTITY	Calreticulin Binds to Fas_Ligand and Inhibits Neuronal Cell Apoptosis Induced by Ischemia-Reperfusion_Injury .
22252758	0	Fas_Ligand	23,33	FasL	35,39	Fas Ligand	FasL	356	356	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of Fas_Ligand -LRB- FasL -RRB- in the lower airways of patients with fibrotic interstitial_lung_diseases -LRB- ILDs -RRB- .
22479266	0	Fas_Ligand	0,10	TNF-a	37,42	Fas Ligand	TNF-a	14103(Tax:10090)	21926(Tax:10090)	Gene	Gene	Has|nsubj|START_ENTITY Has|nmod|END_ENTITY	Fas_Ligand Has a Greater Impact than TNF-a on Apoptosis and Inflammation in Ischemic_Acute_Kidney_Injury .
11380462	0	Fas_antigen	134,145	CD34	34,38	Fas antigen	CD34	355	947	Gene	Gene	apoptosis|nmod|START_ENTITY relationship|nmod|apoptosis expression|dep|relationship expression|nmod|cells cells|nummod|END_ENTITY	Bcl-2 and Bcl-x expression in the CD34 + cells of aplastic_anaemia patients : relationship with increased apoptosis and upregulation of Fas_antigen .
7538820	0	Fas_antigen	0,11	CD34	26,30	Fas antigen	CD34	355	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Fas_antigen expression on CD34 + human marrow cells is induced by interferon_gamma and tumor_necrosis_factor_alpha and potentiates cytokine-mediated hematopoietic suppression in vitro .
7577642	0	Fas_antigen	24,35	CD34	51,55	Fas antigen	CD34	355	947	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Increased expression of Fas_antigen on bone marrow CD34 + cells of patients with aplastic_anaemia .
7541728	0	Fas_antigen	27,38	CD4	60,63	Fas antigen	CD4	355	920	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Differential expression of Fas_antigen and Bcl-2 protein on CD4 + T cells , CD8 + T cells , and monocytes .
11596030	0	Fas_antigen	14,25	CD95	27,31	Fas antigen	CD95	355	355	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Fas_antigen -LRB- CD95 -RRB- in peripheral blood lymphocytes and in liver-infiltrating , cytotoxic lymphocytes in patients with hepatocellular_carcinoma .
7542501	0	Fas_antigen	25,36	CD95	38,42	Fas antigen	CD95	355	355	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Functional expression of Fas_antigen -LRB- CD95 -RRB- on hematopoietic progenitor cells .
9857230	0	Fas_antigen	73,84	Fas_ligand	16,26	Fas antigen	Fas ligand	355	356	Gene	Gene	Cytotoxicity|nmod|START_ENTITY Cytotoxicity|nmod|END_ENTITY	Cytotoxicity of Fas_ligand against lymphoma cells with radiation-induced Fas_antigen .
9376651	0	Fas_antigen	39,50	bcl-2	14,19	Fas antigen	bcl-2	355	596	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|protein protein|amod|END_ENTITY	Expression of bcl-2 protein and APO-1 -LRB- Fas_antigen -RRB- in the lung tissue from patients with idiopathic_pulmonary_fibrosis .
10089905	0	Fas_antigen	0,11	interferon-gamma	67,83	Fas antigen	interferon-gamma	355	3458	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Fas_antigen -LRB- CD95 -RRB- in pure erythroid cell line AS-E2 is induced by interferon-gamma and tumor_necrosis_factor-alpha and potentiates apoptotic death .
7522637	0	Fas_antigen	43,54	interferon-gamma	93,109	Fas antigen	interferon-gamma	355	3458	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|advcl|inducing inducing|dobj|secretion secretion|amod|END_ENTITY	Cross-linking of CD4 molecules upregulates Fas_antigen expression in lymphocytes by inducing interferon-gamma and tumor_necrosis_factor-alpha secretion .
9829628	0	Fas_antigen	28,39	interferon-gamma	60,76	Fas antigen	interferon-gamma	14102(Tax:10090)	15978(Tax:10090)	Gene	Gene	expressions|amod|START_ENTITY expressions|nmod|liver liver|amod|END_ENTITY	Induction of Fas ligand and Fas_antigen mRNA expressions in interferon-gamma transgenic mouse liver .
15938782	0	Fas_antigen	15,26	placental_growth_factor	39,62	Fas antigen	placental growth factor	355	5228	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	-LSB- Expression of Fas_antigen and ligand , placental_growth_factor in placenta of pregnant women with pre-eclampsia -RSB- .
11483211	0	Fas_apoptosis_inhibitory_molecule	38,71	FAIM	73,77	Fas apoptosis inhibitory molecule	FAIM	23873(Tax:10090)	23873(Tax:10090)	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	An alternatively spliced long form of Fas_apoptosis_inhibitory_molecule -LRB- FAIM -RRB- with tissue-specific expression in the brain .
19843941	0	Fas_apoptosis_inhibitory_molecule	0,33	IRF4	77,81	Fas apoptosis inhibitory molecule	IRF4	55179	3662	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Fas_apoptosis_inhibitory_molecule expression in B cells is regulated through IRF4 in a feed-forward mechanism .
11242125	0	Fas_associated_death_domain_protein	31,66	tumor_necrosis_factor-alpha	102,129	Fas associated death domain protein	tumor necrosis factor-alpha	14082(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induced|nsubj|expression induced|nmod|END_ENTITY	mRNA and protein expression of Fas_associated_death_domain_protein in apoptosic hepatocyte induced by tumor_necrosis_factor-alpha .
11112409	0	Fas_binding_protein	23,42	Daxx	15,19	Fas binding protein	Daxx	1616	1616	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Daxx , a Fas_binding_protein , with sentrin and Ubc9 .
11112409	0	Fas_binding_protein	23,42	sentrin	49,56	Fas binding protein	sentrin	1616	7341	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Daxx , a Fas_binding_protein , with sentrin and Ubc9 .
11756562	0	Fas_ligand	37,47	Akt	15,18	Fas ligand	Akt	356	207	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Suppression of Akt signaling induces Fas_ligand expression : involvement of caspase and Jun_kinase activation in Akt-mediated Fas_ligand regulation .
10920278	0	Fas_ligand	36,46	Bcl-2	0,5	Fas ligand	Bcl-2	356	596	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Bcl-2 inhibits calcineurin-mediated Fas_ligand expression in antitumor drug-treated baby hamster kidney cells .
12849704	0	Fas_ligand	109,119	Bcl-2	2,7	Fas ligand	Bcl-2	14103(Tax:10090)	12043(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY destruction|acl|induced protect|nmod|destruction protect|nsubj|transgene transgene|compound|END_ENTITY	A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas_ligand .
21485723	0	Fas_ligand	65,75	Bcl-2	28,33	Fas ligand	Bcl-2	356	596	Gene	Gene	caspase-3|acl|START_ENTITY caspase-3|compound|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
11918536	0	Fas_ligand	80,90	CD178	92,97	Fas ligand	CD178	356	356	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differentiation of promyelocytic leukaemia : alterations in Fas -LRB- CD95/Apo -1 -RRB- and Fas_ligand -LRB- CD178 -RRB- expression .
21808135	0	Fas_ligand	22,32	CD178	34,39	Fas ligand	CD178	356	356	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fas receptor -LRB- CD95 -RRB- _ Fas_ligand -LRB- CD178 -RRB- expression in patients with tobacco-related intraoral_squamous_cell_carcinoma .
10480436	0	Fas_ligand	0,10	CD38	69,73	Fas ligand	CD38	356	952	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|nmod|END_ENTITY	Fas_ligand promotes cell survival of immature human bone marrow CD34 + CD38 - hematopoietic progenitor cells by suppressing apoptosis .
10203105	0	Fas_ligand	91,101	CD4	26,29	Fas ligand	CD4	356	920	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression proliferation|dep|role proliferation|nmod|END_ENTITY	Abnormal proliferation of CD4 - CD8 + gammadelta + T cells with chromosome 6 anomaly : role of Fas_ligand expression in spontaneous regression of the cells .
10447713	0	Fas_ligand	95,105	CD4	33,36	Fas ligand	CD4	14103(Tax:10090)	12504(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|apoptosis apoptosis|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Increased inducible apoptosis in CD4 + T lymphocytes during polymicrobial sepsis is mediated by Fas_ligand and not endotoxin .
10794428	0	Fas_ligand	86,96	CD4	23,26	Fas ligand	CD4	356	920	Gene	Gene	form|dobj|START_ENTITY form|nsubj|Correlation Correlation|nmod|loss loss|nmod|cells cells|compound|END_ENTITY	Correlation of loss of CD4 T cells with plasma levels of both soluble form Fas -LRB- CD95 -RRB- Fas_ligand -LRB- FasL -RRB- in HIV-infected infants .
10891451	0	Fas_ligand	40,50	CD4	0,3	Fas ligand	CD4	356	920	Gene	Gene	express|dobj|START_ENTITY primed|dep|express primed|nsubjpass|lymphocytes lymphocytes|compound|END_ENTITY	CD4 T lymphocytes are primed to express Fas_ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway .
10891451	0	Fas_ligand	40,50	CD4	54,57	Fas ligand	CD4	356	920	Gene	Gene	express|dobj|START_ENTITY express|nmod|cross-linking cross-linking|compound|END_ENTITY	CD4 T lymphocytes are primed to express Fas_ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway .
11272277	0	Fas_ligand	126,136	CD4	53,56	Fas ligand	CD4	356	920	Gene	Gene	Fas|dep|START_ENTITY up-regulation|nmod|Fas apoptosis|nmod|up-regulation apoptosis|compound|END_ENTITY	Stromal derived factor-1 alpha -LRB- SDF-1 alpha -RRB- induces CD4 + T cell apoptosis via the functional up-regulation of the Fas -LRB- CD95 -RRB- / Fas_ligand -LRB- CD95L -RRB- pathway .
11414736	0	Fas_ligand	46,56	CD4	89,92	Fas ligand	CD4	356	920	Gene	Gene	consequences|nmod|START_ENTITY produced|nsubj|consequences produced|nmod|response response|compound|T T|compound|END_ENTITY	Positive and negative consequences of soluble Fas_ligand produced by an antigen-specific CD4 -LRB- + -RRB- T cell response in human carcinoma immune interactions .
11435308	0	Fas_ligand	105,115	CD4	133,136	Fas ligand	CD4	356	920	Gene	Gene	START_ENTITY|dobj|cells cells|amod|END_ENTITY	Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas_ligand double-defective CD4 -LRB- + -RRB- donor T cells : involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host_disease pathogenesis .
15124861	0	Fas_ligand	80,90	CD4	55,58	Fas ligand	CD4	356	920	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Elimination of activated but not resting primary human CD4 + and CD8 + T cells by Fas_ligand -LRB- FasL/CD95L -RRB- - expressing Killer-dendritic cells .
15588377	0	Fas_ligand	111,121	CD4	65,68	Fas ligand	CD4	356	920	Gene	Gene	express|dobj|START_ENTITY +|ccomp|express +|nsubj|CD8 CD8|compound|END_ENTITY	Intrathyroidal CD4 + T lymphocytes express high levels of Fas and CD4 + CD8 + macrophages/dendritic cells express Fas_ligand in autoimmune_thyroid_disease .
15894587	0	Fas_ligand	10,20	CD4	35,38	Fas ligand	CD4	356	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Increased Fas_ligand expression of CD4 + T cells by HCV core induces T cell-dependent hepatic_inflammation .
17595676	0	Fas_ligand	20,30	CD4	51,54	Fas ligand	CD4	356	920	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IFN-gamma regulates Fas_ligand expression in human CD4 + T lymphocytes and controls their anti-mycobacterial cytotoxic functions .
20637014	0	Fas_ligand	55,65	CD4	85,88	Fas ligand	CD4	14103(Tax:10090)	12504(Tax:10090)	Gene	Gene	plays|nmod|START_ENTITY plays|nmod|T T|compound|END_ENTITY	Organ microenvironment plays significant roles through Fas_ligand in vaccine-induced CD4 -LRB- + -RRB- T cell dependent suppression of tumor growth at the orthotopic site .
8675212	0	Fas_ligand	18,28	CD4	43,46	Fas ligand	CD4	356	920	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	HIV-1 upregulates Fas_ligand expression in CD4 + T cells in vitro and in vivo : association with Fas-mediated apoptosis and modulation by aurintricarboxylic_acid .
9480981	0	Fas_ligand	32,42	CD4	0,3	Fas ligand	CD4	356	920	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CD4 regulates susceptibility to Fas_ligand - and tumor necrosis factor-mediated apoptosis .
9548519	0	Fas_ligand	102,112	CD4	25,28	Fas ligand	CD4	356	920	Gene	Gene	expression|compound|START_ENTITY level|nmod|expression inhibits|nmod|level inhibits|nsubj|Ligation Ligation|nmod|END_ENTITY	Ligation of cell surface CD4 inhibits activation-induced death of human T lymphocytes at the level of Fas_ligand expression .
9846574	0	Fas_ligand	26,36	CD4	65,68	Fas ligand	CD4	356	920	Gene	Gene	discovered|nmod|START_ENTITY discovered|nmod|arrest arrest|nmod|cells cells|compound|END_ENTITY	Newly discovered role for Fas_ligand in the cell-cycle arrest of CD4 + T cells .
10203105	0	Fas_ligand	91,101	CD8	31,34	Fas ligand	CD8	356	925	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression proliferation|dep|role proliferation|dep|cells cells|compound|END_ENTITY	Abnormal proliferation of CD4 - CD8 + gammadelta + T cells with chromosome 6 anomaly : role of Fas_ligand expression in spontaneous regression of the cells .
10653855	0	Fas_ligand	51,61	CD8	107,110	Fas ligand	CD8	356	925	Gene	Gene	secretion|compound|START_ENTITY induce|dobj|secretion induce|nmod|Fas Fas|compound|END_ENTITY	Soluble human MHC class I molecules induce soluble Fas_ligand secretion and trigger apoptosis in activated CD8 -LRB- + -RRB- Fas -LRB- CD95 -RRB- -LRB- + -RRB- T lymphocytes .
11067907	0	Fas_ligand	0,10	CD8	53,56	Fas ligand	CD8	356	925	Gene	Gene	costimulates|nsubj|START_ENTITY costimulates|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Fas_ligand costimulates the in vivo proliferation of CD8 + T cells .
11555580	0	Fas_ligand	0,10	CD8	74,77	Fas ligand	CD8	356	925	Gene	Gene	expression|compound|START_ENTITY mediates|nsubj|expression mediates|dobj|elimination elimination|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Fas_ligand expression by neoplastic T lymphocytes mediates elimination of CD8 + cytotoxic T lymphocytes in mycosis fungoides : a potential mechanism of tumor immune escape ?
12594270	0	Fas_ligand	67,77	CD8	26,29	Fas ligand	CD8	356	925	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression Inhibition|dep|regulation Inhibition|nmod|death death|compound|END_ENTITY	Inhibition of TCR-induced CD8 T cell death by IL-12 : regulation of Fas_ligand and cellular FLIP expression and caspase activation by IL-12 .
15588377	0	Fas_ligand	111,121	CD8	70,73	Fas ligand	CD8	356	925	Gene	Gene	express|dobj|START_ENTITY +|ccomp|express +|nsubj|END_ENTITY	Intrathyroidal CD4 + T lymphocytes express high levels of Fas and CD4 + CD8 + macrophages/dendritic cells express Fas_ligand in autoimmune_thyroid_disease .
16081306	0	Fas_ligand	26,36	CD8	45,48	Fas ligand	CD8	356	925	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Tumor exosomes expressing Fas_ligand mediate CD8 + T-cell apoptosis .
16301629	0	Fas_ligand	107,117	CD8	67,70	Fas ligand	CD8	356	925	Gene	Gene	Fas|compound|START_ENTITY Fas|nsubj|Apoptosis Apoptosis|nmod|lymphocytes lymphocytes|nmod|engagement engagement|nmod|END_ENTITY	Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas_ligand / Fas mediated : evidence for the involvement of p56lck , calcium calmodulin kinase II , and Calcium-independent protein kinase C signaling pathways and for NF-kappaB and NF-AT nuclear translocation .
8566027	0	Fas_ligand	35,45	CD8	60,63	Fas ligand	CD8	356	925	Gene	Gene	START_ENTITY|nmod|clones clones|nummod|END_ENTITY	Two signaling pathways can lead to Fas_ligand expression in CD8 + cytotoxic T lymphocyte clones .
9190908	0	Fas_ligand	13,23	CD8	57,60	Fas ligand	CD8	356	925	Gene	Gene	Fas|compound|START_ENTITY induces|dobj|Fas induces|nmod|+ +|compound|END_ENTITY	IL-2 induces Fas_ligand / Fas -LRB- CD95L/CD95 -RRB- cytotoxicity in CD8 + and CD4 + T lymphocyte clones .
9817448	0	Fas_ligand	26,36	CD8	45,48	Fas ligand	CD8	356	925	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|T T|compound|END_ENTITY	Predominant expression of Fas_ligand mRNA in CD8 + T lymphocytes in patients with HTLV-1 associated myelopathy .
11429161	0	Fas_ligand	63,73	CD95	75,79	Fas ligand	CD95	356	355	Gene	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Molecular cloning , characterization , and expression of porcine Fas_ligand -LRB- CD95 ligand -RRB- .
13679638	0	Fas_ligand	61,71	CD95L	73,78	Fas ligand	CD95L	14103(Tax:10090)	14103(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Modification of tumor cells with Fas -LRB- CD95 -RRB- antigen gene and Fas_ligand -LRB- CD95L -RRB- gene transfection by electroporation for immunotherapy of cancer .
18648368	0	Fas_ligand	28,38	EP1	58,61	Fas ligand	EP1	356	5731	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin_E2 stimulates Fas_ligand expression via the EP1 receptor in colon_cancer cells .
9915863	0	Fas_ligand	34,44	Egr-2	8,13	Fas ligand	Egr-2	356	1959	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Role of Egr-2 in up-regulation of Fas_ligand in normal T cells and aberrant double-negative lpr and gld T cells .
9632757	0	Fas_ligand	61,71	Egr-3	45,50	Fas ligand	Egr-3	356	1960	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas_ligand expression .
11970950	0	Fas_ligand	27,37	Ets-1	0,5	Fas ligand	Ets-1	356	2113	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Ets-1 positively regulates Fas_ligand transcription via cooperative interactions with Sp1 .
18204739	0	Fas_ligand	48,58	FIP	80,83	Fas ligand	FIP	356	7392	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Cloning and purification of functionally active Fas_ligand interfering protein -LRB- FIP -RRB- expressed in Escherichia_coli .
12594270	0	Fas_ligand	67,77	FLIP	91,95	Fas ligand	FLIP	356	8837	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of TCR-induced CD8 T cell death by IL-12 : regulation of Fas_ligand and cellular FLIP expression and caspase activation by IL-12 .
10571510	0	Fas_ligand	18,28	FasL	30,34	Fas ligand	FasL	356	356	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Fas_ligand -LRB- FasL -RRB- during malignant transformation in the large bowel and in Barrett 's metaplasia of the esophagus .
15387375	0	Fas_ligand	33,43	FasL	45,49	Fas ligand	FasL	14103(Tax:10090)	14103(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Essential role for hematopoietic Fas_ligand -LRB- FasL -RRB- in the suppression of melanoma lung metastasis revealed in bone marrow chimeric mice .
20013612	0	Fas_ligand	0,10	FasL	12,16	Fas ligand	FasL	356	356	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fas_ligand -LRB- FasL , Apo-1L / CD95L -RRB- expression and clinical outcome in papillary_microcarcinoma and papillary_thyroid_carcinomas with diameter smaller than 1.5 centimeters .
9284765	0	Fas_ligand	37,47	FasL	49,53	Fas ligand	FasL	356	356	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the apoptosis-inducing Fas_ligand -LRB- FasL -RRB- in human first and third trimester placenta and choriocarcinoma cells .
9566799	0	Fas_ligand	17,27	FasL	29,33	Fas ligand	FasL	356	356	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Up-regulation of Fas_ligand -LRB- FasL -RRB- mRNA expression in peripheral blood mononuclear cells -LRB- PBMC -RRB- after major surgery .
9857230	0	Fas_ligand	16,26	Fas_antigen	73,84	Fas ligand	Fas antigen	356	355	Gene	Gene	Cytotoxicity|nmod|START_ENTITY Cytotoxicity|nmod|END_ENTITY	Cytotoxicity of Fas_ligand against lymphoma cells with radiation-induced Fas_antigen .
21605112	0	Fas_ligand	52,62	FcgammaRIIB	20,31	Fas ligand	FcgammaRIIB	356	2213	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A critical role for FcgammaRIIB in up-regulation of Fas_ligand induced by a microbial polysaccharide .
18789888	0	Fas_ligand	48,58	Grb2	20,24	Fas ligand	Grb2	356	2885	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The adaptor protein Grb2 regulates cell surface Fas_ligand in Schwann cells .
17595676	0	Fas_ligand	20,30	IFN-gamma	0,9	Fas ligand	IFN-gamma	356	3458	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-gamma regulates Fas_ligand expression in human CD4 + T lymphocytes and controls their anti-mycobacterial cytotoxic functions .
9973455	0	Fas_ligand	0,10	IL-1	102,106	Fas ligand	IL-1	356	3552	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Fas_ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1 , IL-6 , TNF-alpha , or IFN-gamma .
16339539	0	Fas_ligand	0,10	IL-23	35,40	Fas ligand	IL-23	14103(Tax:10090)	83430(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Fas_ligand induces cell-autonomous IL-23 production in dendritic cells , a mechanism for Fas_ligand-induced IL-17 production .
9413156	0	Fas_ligand	24,34	Interleukin_18	0,14	Fas ligand	Interleukin 18	356	3606	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin_18 enhances Fas_ligand expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells .
10837465	0	Fas_ligand	53,63	NF-kappa_B	4,14	Fas ligand	NF-kappa B	356	4790	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	The NF-kappa_B signaling pathway is not required for Fas_ligand gene induction but mediates protection from activation-induced cell death .
16595635	0	Fas_ligand	39,49	Nck	20,23	Fas ligand	Nck	356	4690	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The adaptor protein Nck interacts with Fas_ligand : Guiding the death factor to the cytotoxic immunological synapse .
19641134	0	Fas_ligand	15,25	RIP1	35,39	Fas ligand	RIP1	356	8737	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Membrane-bound Fas_ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex .
11549697	0	Fas_ligand	28,38	TNFalpha	0,8	Fas ligand	TNFalpha	356	7124	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	TNFalpha down-regulates the Fas_ligand and inhibits germ cell apoptosis in the human testis .
9546786	0	Fas_ligand	23,33	TNFalpha	0,8	Fas ligand	TNFalpha	356	7124	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	TNFalpha regulation of Fas_ligand expression on the vascular endothelium modulates leukocyte extravasation .
17264490	0	Fas_ligand	12,22	TRAIL	66,71	Fas ligand	TRAIL	356	8743	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of Fas_ligand and TNF-related apoptosis-inducing ligand -LRB- TRAIL -RRB- in the ocular immune response .
9892606	0	Fas_ligand	42,52	Transforming_growth_factor_beta1	0,32	Fas ligand	Transforming growth factor beta1	356	7040	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta1 inhibits Fas_ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc .
10544014	0	Fas_ligand	81,91	Tumor_necrosis_factor-alpha	0,27	Fas ligand	Tumor necrosis factor-alpha	356	7124	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha and interferon-gamma induce expression of functional Fas_ligand on HT29 and MCF7 adenocarcinoma cells .
10229231	0	Fas_ligand	14,24	apoptosis-linked_gene_4	54,77	Fas ligand	apoptosis-linked gene 4	356	22984	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of Fas_ligand expression and cell death by apoptosis-linked_gene_4 .
12168058	0	Fas_ligand	33,43	bcl-2	45,50	Fas ligand	bcl-2	356	596	Gene	Gene	Fas|dep|START_ENTITY Fas|dep|END_ENTITY	Apoptosis-related proteins -LRB- Fas , Fas_ligand , bcl-2 and p53 -RRB- in different types of human breast_tumors .
12535213	0	Fas_ligand	0,10	caspase-8	86,95	Fas ligand	caspase-8	356	841	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Fas_ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8 .
18435487	0	Fas_ligand	90,100	focal_adhesion_kinase	43,64	Fas ligand	focal adhesion kinase	356	5747	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Geraniin-mediated apoptosis by cleavage of focal_adhesion_kinase through up-regulation of Fas_ligand expression in human melanoma cells .
25139496	0	Fas_ligand	24,34	granzyme_B	36,46	Fas ligand	granzyme B	356	3002	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Serum levels of soluble Fas_ligand , granzyme_B and cytochrome_c during adjuvant chemotherapy of breast_cancer .
11836588	0	Fas_ligand	14,24	nasopharyngeal_carcinoma	76,100	Fas ligand	nasopharyngeal carcinoma	356	4864	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Fas_ligand in patients with evident skull base involvement of nasopharyngeal_carcinoma .
11446471	0	Fas_ligand	55,65	p53	67,70	Fas ligand	p53	356	7157	Gene	Gene	Fas|dep|START_ENTITY Fas|dep|END_ENTITY	Lymphoid elements and apoptosis-related proteins -LRB- Fas , Fas_ligand , p53 and bcl-2 -RRB- in lichen_sclerosus and carcinoma_of_the_vulva .
15073283	0	Fas_ligand	14,24	vascular_endothelial_growth_factor	39,73	Fas ligand	vascular endothelial growth factor	356	7422	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of Fas_ligand expression by vascular_endothelial_growth_factor in endometrial stromal cells in vitro .
23888906	0	Fasciculation_and_elongation_protein_zeta-1	0,43	FEZ1	45,49	Fasciculation and elongation protein zeta-1	FEZ1	81730(Tax:10116)	81730(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- expression in reactive astrocytes in a rat model of Parkinson 's _ disease .
15749076	0	Fat	66,69	protocadherin	46,59	Fat	protocadherin	406172(Tax:7955)	406172(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and expression of the large zebrafish protocadherin gene , Fat .
26099526	0	Fat-Specific_Protein_27	0,23	CIDEC	24,29	Fat-Specific Protein 27	CIDEC	14311(Tax:10090)	14311(Tax:10090)	Gene	Gene	START_ENTITY|dep|Development Development|compound|END_ENTITY	Fat-Specific_Protein_27 / CIDEC Promotes Development of Alcoholic_Steatohepatitis in Mice and Humans .
24627478	0	Fat-specific_protein_27	0,23	adipose_triglyceride_lipase	47,74	Fat-specific protein 27	adipose triglyceride lipase	63924	57104	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fat-specific_protein_27 -LRB- FSP27 -RRB- interacts with adipose_triglyceride_lipase -LRB- ATGL -RRB- to regulate lipolysis and insulin sensitivity in human adipocytes .
24742676	0	Fat-specific_protein_27	0,23	adipose_triglyceride_lipase	130,157	Fat-specific protein 27	adipose triglyceride lipase	63924	57104	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|facilitating facilitating|nmod|transcription transcription|nmod|END_ENTITY	Fat-specific_protein_27 inhibits lipolysis by facilitating the inhibitory effect of transcription factor Egr1 on transcription of adipose_triglyceride_lipase .
23233732	0	Fat-specific_protein_27	0,23	nuclear_factor_of_activated_T_cells_5	34,71	Fat-specific protein 27	nuclear factor of activated T cells 5	63924	10725	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Fat-specific_protein_27 modulates nuclear_factor_of_activated_T_cells_5 and the cellular response to stress .
26209645	0	Fat1	0,4	Fat4	20,24	Fat1	Fat4	14107(Tax:10090)	329628(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fat1 interacts with Fat4 to regulate neural tube closure , neural progenitor proliferation and apical constriction during mouse brain development .
26209645	0	Fat4	20,24	Fat1	0,4	Fat4	Fat1	329628(Tax:10090)	14107(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fat1 interacts with Fat4 to regulate neural tube closure , neural progenitor proliferation and apical constriction during mouse brain development .
26218273	0	Fat_Mass_and_Obesity_Associated_Protein	33,72	Demethylase	4,15	Fat Mass and Obesity Associated Protein	Demethylase	79068	8932	Gene	Gene	Activity|appos|START_ENTITY Activity|amod|END_ENTITY	The Demethylase Activity of FTO -LRB- Fat_Mass_and_Obesity_Associated_Protein -RRB- Is Required for Preadipocyte Differentiation .
11825870	0	Fat_facets	94,104	Liquid_facets	60,73	Fat facets	Liquid facets	43749(Tax:7227)	38846(Tax:7227)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	A specific protein substrate for a deubiquitinating enzyme : Liquid_facets is the substrate of Fat_facets .
14588248	0	Fat_facets	0,10	vasa	26,30	Fat facets	vasa	43749(Tax:7227)	26067080	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fat_facets interacts with vasa in the Drosophila pole plasm and protects it from degradation .
23236435	0	Fat_mass_and_obesity_associated_gene	0,36	FTO	38,41	Fat mass and obesity associated gene	FTO	79068	79068	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fat_mass_and_obesity_associated_gene -LRB- FTO -RRB- expression is regulated negatively by the transcription factor Foxa2 .
23236435	0	Fat_mass_and_obesity_associated_gene	0,36	Foxa2	106,111	Fat mass and obesity associated gene	Foxa2	79068	3170	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Fat_mass_and_obesity_associated_gene -LRB- FTO -RRB- expression is regulated negatively by the transcription factor Foxa2 .
25754762	0	Fatty_Acid_Amide_Hydrolase	11,37	FAAH	39,43	Fatty Acid Amide Hydrolase	FAAH	2166	2166	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Effects of Fatty_Acid_Amide_Hydrolase -LRB- FAAH -RRB- Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse .
17786362	0	Fatty_Acid_Synthase	14,33	FASN	35,39	Fatty Acid Synthase	FASN	2194	2194	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of Fatty_Acid_Synthase -LRB- FASN -RRB- synergistically enhances the efficacy of 5-fluorouracil in breast_carcinoma cells .
19625659	0	Fatty_acid_binding_protein_4	0,28	VEGF	44,48	Fatty acid binding protein 4	VEGF	2167	7422	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Fatty_acid_binding_protein_4 is a target of VEGF and a regulator of cell proliferation in endothelial cells .
17704768	0	Fbl10	18,23	c-Jun	64,69	Fbl10	c-Jun	84678	3725	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun .
16338003	0	Fbln1	49,54	fibulin-1	38,47	Fbln1	fibulin-1	14114(Tax:10090)	14114(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Expression and functional analysis of fibulin-1 -LRB- Fbln1 -RRB- during normal and abnormal placental development of the mouse .
19297328	0	Fbw1a	29,34	p300	50,54	Fbw1a	p300	8945	2033	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The F-box protein beta-TrCp1 / Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity .
26542806	0	Fbw7	20,24	E3_Ubiquitin_Ligase	0,19	Fbw7	E3 Ubiquitin Ligase	55294	158506	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|compound|END_ENTITY	E3_Ubiquitin_Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation .
23820376	0	Fbw7	20,24	G-CSFR	88,94	Fbw7	G-CSFR	55294	1441	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation .
24820417	0	Fbw7	0,4	GATA3	13,18	Fbw7	GATA3	50754(Tax:10090)	14462(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Fbw7 targets GATA3 through cyclin-dependent_kinase_2-dependent proteolysis and contributes to regulation of T-cell development .
26542806	0	Fbw7	20,24	Runx2	86,91	Fbw7	Runx2	55294	860	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	E3_Ubiquitin_Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation .
20543859	0	Fbw7	53,57	SCF	49,52	Fbw7	SCF	55294	4254	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	The ubiquitous nature of cancer : the role of the SCF -LRB- Fbw7 -RRB- complex in development and transformation .
19421138	0	Fbw7	0,4	c-Myb	49,54	Fbw7	c-Myb	50754(Tax:10090)	17863(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Fbw7 promotes ubiquitin-dependent degradation of c-Myb : involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb .
23776410	0	Fbw7	0,4	hes5	19,23	Fbw7	hes5	50754(Tax:10090)	15208(Tax:10090)	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions .
12665572	0	Fbx15	0,5	Oct3/4	27,33	Fbx15	Oct3/4	50764(Tax:10090)	18999(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development .
19716789	0	Fbx6	18,22	Chk1	33,37	Fbx6	Chk1	26270	1111	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress .
25725482	0	Fbxo25	0,6	Tbx5	16,20	Fbxo25	Tbx5	26260	6910	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|activity activity|amod|END_ENTITY	Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development .
25143387	0	Fbxo45	0,6	N-cadherin	49,59	Fbxo45	N-cadherin	200933	1000	Gene	Gene	Proteolysis|compound|START_ENTITY Proteolysis|nmod|END_ENTITY	Fbxo45 Inhibits Calcium-sensitive Proteolysis of N-cadherin and Promotes Neuronal Differentiation .
22910413	0	Fbxw5	0,5	c-Myb	25,30	Fbxw5	c-Myb	54461	4602	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|amod|END_ENTITY	Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation .
22513362	0	Fbxw7	44,49	Aurora-A	15,23	Fbxw7	Aurora-A	50754(Tax:10090)	20878(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development .
23955342	0	Fbxw7	41,46	F-box_and_WD_repeat_domain-containing-7	0,39	Fbxw7	F-box and WD repeat domain-containing-7	50754(Tax:10090)	50754(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	F-box_and_WD_repeat_domain-containing-7 -LRB- Fbxw7 -RRB- protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation .
22513362	0	Fbxw7	44,49	Pten	0,4	Fbxw7	Pten	50754(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development .
26458995	0	Fbxw7	0,5	RhoA	112,116	Fbxw7	RhoA	55294	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Fbxw7 regulates tumor apoptosis , growth_arrest and the epithelial-to-mesenchymal transition in part through the RhoA signaling pathway in gastric_cancer .
20622901	0	Fbxw7	17,22	TGFb	33,37	Fbxw7	TGFb	55294	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tumor suppressor Fbxw7 regulates TGFb signaling by targeting TGIF1 for degradation .
24594077	0	Fc-gamma_receptor_IIa	20,41	CD32	43,47	Fc-gamma receptor IIa	CD32	2212	2212	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between Fc-gamma_receptor_IIa -LRB- CD32 -RRB- gene polymorphism and malaria susceptibility : a meta-analysis based on 6928 subjects .
18313765	0	Fc-receptor_like-3	33,51	FCRL3	53,58	Fc-receptor like-3	FCRL3	115352	115352	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The high producer variant of the Fc-receptor_like-3 -LRB- FCRL3 -RRB- gene is involved in protection against multiple_sclerosis .
16439682	0	FcRH5	45,50	CBF1	70,74	FcRH5	CBF1	83416	3516	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Epstein-Barr_virus nuclear antigen 2 induces FcRH5 expression through CBF1 .
16681430	0	FcRH5	99,104	CD307	106,111	FcRH5	CD307	83416	83416	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
16681430	0	FcRH5	99,104	IRTA2	92,97	FcRH5	IRTA2	83416	83416	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
16681430	0	FcRH5	99,104	immunoglobulin_superfamily_receptor_translocation-associated_2	28,90	FcRH5	immunoglobulin superfamily receptor translocation-associated 2	83416	83416	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
26634928	0	FcRn	48,52	Fc_receptor	35,46	FcRn	Fc receptor	2217	2217	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the human neonatal Fc_receptor -LRB- FcRn -RRB- in human nasal epithelium .
27012525	0	FcRn	53,57	Fc_receptor	40,51	FcRn	Fc receptor	2217	2217	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Quantitative analysis of human neonatal Fc_receptor -LRB- FcRn -RRB- tissue expression in transgenic_mice by online peptide immuno-affinity LC-HRMS .
26260795	0	FcRn	43,47	Neonatal_Fc_Receptor	21,41	FcRn	Neonatal Fc Receptor	2217	2217	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Critical Role of the Neonatal_Fc_Receptor -LRB- FcRn -RRB- in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus_Vulgaris .
15103747	0	FcRn	75,79	pIgR	120,124	FcRn	pIgR	100144766(Tax:9940)	100144764(Tax:9940)	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Effects of mycophenolic_acid -LRB- MPA -RRB- treatment on expression of Fc receptor -LRB- FcRn -RRB- and polymeric immunoglobulin receptor -LRB- pIgR -RRB- mRNA in adult sheep tissues .
25340460	0	Fc_Gamma_Receptor_IIb	0,21	GM-CSF	25,31	Fc Gamma Receptor IIb	GM-CSF	2213	1437	Gene	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	Fc_Gamma_Receptor_IIb on GM-CSF Macrophages Controls Immune Complex Mediated Inhibition of Inflammatory Signals .
7925881	0	Fc_alpha-receptor	0,17	THP-1	61,66	Fc alpha-receptor	THP-1	2204	2736	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Fc_alpha-receptor expression on the myelomonocytic cell line THP-1 : comparison with human alveolar macrophages .
12244179	0	Fc_alpha_R	45,55	CD89	57,61	Fc alpha R	CD89	2204	2204	Gene	Gene	binding|compound|START_ENTITY binding|appos|END_ENTITY	Mac-1 -LRB- CD11b/CD18 -RRB- as accessory molecule for Fc_alpha_R -LRB- CD89 -RRB- binding of IgA .
9862725	0	Fc_epsilonRI	30,42	IL-4	0,4	Fc epsilonRI	IL-4	14127(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits mouse mast cell Fc_epsilonRI expression through a STAT6-dependent mechanism .
16585575	0	Fc_epsilonRII	49,62	CD23	43,47	Fc epsilonRII	CD23	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential T cell-mediated regulation of CD23 -LRB- Fc_epsilonRII -RRB- in B cells and follicular dendritic cells .
11120849	0	Fc_epsilon_RI	121,134	CCR3	96,100	Fc epsilon RI	CCR3	2205	1232	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Tat protein is an HIV-1-encoded beta-chemokine homolog that promotes migration and up-regulates CCR3 expression on human Fc_epsilon_RI + cells .
7522630	0	Fc_epsilon_RI	117,130	CD34	111,115	Fc epsilon RI	CD34	2205	947	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34 + / Fc_epsilon_RI - cell population .
11441085	0	Fc_epsilon_RI	14,27	IL-10	73,78	Fc epsilon RI	IL-10	2205	3586	Gene	Gene	Engagement|nmod|START_ENTITY induces|nsubj|Engagement induces|dobj|production production|nmod|END_ENTITY	Engagement of Fc_epsilon_RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells .
14978125	0	Fc_epsilon_RI	15,28	IL-10	0,5	Fc epsilon RI	IL-10	14125(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-10 inhibits Fc_epsilon_RI expression in mouse mast cells .
10623799	0	Fc_epsilon_RI	54,67	IL-4	20,24	Fc epsilon RI	IL-4	2205	3565	Gene	Gene	cells|compound|START_ENTITY release|nmod|cells release|compound|END_ENTITY	HIV-1 gp120 induces IL-4 and IL-13 release from human Fc_epsilon_RI + cells through interaction with the VH3 region of IgE .
12574351	0	Fc_epsilon_RI	82,95	IL-4	46,50	Fc epsilon RI	IL-4	2205	3565	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human Fc_epsilon_RI + cells through interaction with the kappa light chains of IgE .
8921414	0	Fc_epsilon_RI	45,58	IL-4	83,87	Fc epsilon RI	IL-4	2205	3565	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|cells cells|nmod|END_ENTITY	Induction of the high-affinity IgE receptor -LRB- Fc_epsilon_RI -RRB- on human mast cells by IL-4 .
9820545	0	Fc_epsilon_RI	70,83	IL-4	44,48	Fc epsilon RI	IL-4	2205	3565	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Endogenous superallergen protein Fv induces IL-4 secretion from human Fc_epsilon_RI + cells through interaction with the VH3 region of IgE .
15879091	0	Fc_epsilon_RI	30,43	TGF-beta_1	0,10	Fc epsilon RI	TGF-beta 1	2205	7040	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TGF-beta_1 inhibits mast cell Fc_epsilon_RI expression .
8294882	0	Fc_epsilon_RI	67,80	immunoglobulin_E	39,55	Fc epsilon RI	immunoglobulin E	2205	3497	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Expression of functional high affinity immunoglobulin_E receptors -LRB- Fc_epsilon_RI -RRB- on monocytes of atopic individuals .
7594502	0	Fc_epsilon_RI	13,26	p21ras	0,6	Fc epsilon RI	p21ras	14125(Tax:10090)	15461(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	p21ras links Fc_epsilon_RI to NF-AT family member in mast cells .
1830067	5	Fc_epsilon_RII	630,644	CD23	645,649	Fc epsilon RII	CD23	2208	2208	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Using two-dimensional flow cytometry , more than 10 % of the Fc_epsilon_RII / CD23 + cells were found to co-express CD3 Ag .
7547698	0	Fc_epsilon_RII	33,47	CD23	48,52	Fc epsilon RII	CD23	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TNF-alpha regulates IL-4-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
7692241	2	Fc_epsilon_RII	389,403	CD23	404,408	Fc epsilon RII	CD23	2208	2208	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Zymosan opsonized with human serum enhanced not only the expression of surface Fc_epsilon_RII / CD23 but also Fc_epsilon_RII / CD23 mRNA detected by Northern blot and in situ hybridization techniques .
7947461	0	Fc_epsilon_RII	15,29	CD23	30,34	Fc epsilon RII	CD23	2208	2208	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|pathway pathway|compound|END_ENTITY	Involvement of Fc_epsilon_RII / CD23 and L-arginine-dependent pathway in IgE-mediated stimulation of human monocyte functions .
8039805	0	Fc_epsilon_RII	69,83	CD23	84,88	Fc epsilon RII	CD23	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Purified excretory-secretory component of filarial parasite enhances Fc_epsilon_RII / CD23 expression on human splenic B and T cells and IgE synthesis while potentiating T-helper type 2-related cytokine generation from T cells .
8074665	0	Fc_epsilon_RII	15,29	CD23	30,34	Fc epsilon RII	CD23	2208	2208	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of Fc_epsilon_RII / CD23 and L-arginine dependent pathway in IgE-mediated activation of human eosinophils .
8144928	0	Fc_epsilon_RII	25,39	CD23	41,45	Fc epsilon RII	CD23	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of the murine Fc_epsilon_RII -LRB- CD23 -RRB- gene .
8559149	0	Fc_epsilon_RII	4,18	CD23	19,23	Fc epsilon RII	CD23	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The Fc_epsilon_RII / CD23 gene is actively transcribed during all stages of murine B-lymphocyte development .
8722638	0	Fc_epsilon_RII	57,71	CD23	72,76	Fc epsilon RII	CD23	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Granulocyte_macrophage_colony_stimulating_factor induces Fc_epsilon_RII / CD23 expression on normal human polymorphonuclear neutrophils .
9100439	0	Fc_epsilon_RII	38,52	CD23	53,57	Fc epsilon RII	CD23	14128(Tax:10090)	14128(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Effects of anti-IgE mAb on serum IgE , Fc_epsilon_RII / CD23 expression on splenic B cells and worm burden in mice infected with Paragonimus_westermani .
8722638	0	Fc_epsilon_RII	57,71	Granulocyte_macrophage_colony_stimulating_factor	0,48	Fc epsilon RII	Granulocyte macrophage colony stimulating factor	2208	1437	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Granulocyte_macrophage_colony_stimulating_factor induces Fc_epsilon_RII / CD23 expression on normal human polymorphonuclear neutrophils .
8977198	0	Fc_epsilon_RII	96,110	IL-4	48,52	Fc epsilon RII	IL-4	14128(Tax:10090)	16189(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc_epsilon_RII -LRB- CD23 -RRB- : comparison with the germline epsilon promoter .
7547698	0	Fc_epsilon_RII	33,47	TNF-alpha	0,9	Fc epsilon RII	TNF-alpha	2208	7124	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TNF-alpha regulates IL-4-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
2152043	0	Fc_epsilon_RII	65,79	interleukin-4	13,26	Fc epsilon RII	interleukin-4	2208	3565	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of interleukin-4 and platelet-activating_factor on the Fc_epsilon_RII / CD23 expression on human monocytes .
9286385	0	Fc_epsilon_RI_alpha	13,32	interleukin_4	63,76	Fc epsilon RI alpha	interleukin 4	2205	3565	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Induction of Fc_epsilon_RI_alpha mRNA and protein synthesis by interleukin_4 in CD34 + cells-derived CD1a + dendritic cells .
1682274	0	Fc_epsilon_receptor_II	54,76	CD23	77,81	Fc epsilon receptor II	CD23	2208	2208	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Beta-2-adrenoceptor agonists up-regulate the in vitro Fc_epsilon_receptor_II / CD23 expression on , and release from , the promonocytic cell line U937 and human blood monocytes .
11903052	0	Fc_gamma-receptor	35,52	protein_kinase_D	15,31	Fc gamma-receptor	protein kinase D	2209	5587	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Involvement of protein_kinase_D in Fc_gamma-receptor activation of the NADPH oxidase in neutrophils .
8993006	0	Fc_gammaRI	53,63	CD64	65,69	Fc gammaRI	CD64	2209	2209	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Cytolytic and cytostatic properties of an anti-human Fc_gammaRI -LRB- CD64 -RRB- x epidermal growth factor bispecific fusion protein .
7692930	0	Fc_gamma_R-III	13,27	CD16	29,33	Fc gamma R-III	CD16	2214	2214	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of Fc_gamma_R-III -LRB- CD16 -RRB- expression on neutrophils affected by paroxysmal_nocturnal_haemoglobinuria by administration of granulocyte colony-stimulating factor .
19155486	0	Fc_gamma_RI	52,63	C-reactive_protein	25,43	Fc gamma RI	C-reactive protein	14129(Tax:10090)	12944(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY activated|nmod|suppression activated|nmod|END_ENTITY	Macrophages activated by C-reactive_protein through Fc_gamma_RI transfer suppression of immune thrombocytopenia .
7636267	0	Fc_gamma_RI	28,39	C-reactive_protein	0,18	Fc gamma RI	C-reactive protein	2209	1401	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	C-reactive_protein binds to Fc_gamma_RI in transfected COS cells .
9765917	0	Fc_gamma_RI	59,70	Extracellular_signal-regulated_kinase_1	0,39	Fc gamma RI	Extracellular signal-regulated kinase 1	2209	5595	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Extracellular_signal-regulated_kinase_1 or 2 activation by Fc_gamma_RI aggregation in U937 cells .
2141616	0	Fc_gamma_RI	40,51	IFN-gamma	60,69	Fc gamma RI	IFN-gamma	2209	3458	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Regulation of the steady state level of Fc_gamma_RI mRNA by IFN-gamma and dexamethasone in human monocytes , neutrophils , and U-937 cells .
7522622	0	Fc_gamma_RI	34,45	p72syk	24,30	Fc gamma RI	p72syk	2209	6850	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Protein-tyrosine kinase p72syk in Fc_gamma_RI receptor signaling .
8132624	0	Fc_gamma_RII	81,93	THP-1	107,112	Fc gamma RII	THP-1	14130(Tax:10090)	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Physical and functional association of Src-related protein tyrosine kinases with Fc_gamma_RII in monocytic THP-1 cells .
7577649	0	Fc_gamma_RIIA	43,56	CD32A	58,63	Fc gamma RIIA	CD32A	2212	2212	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Quantitation of soluble and membrane-bound Fc_gamma_RIIA -LRB- CD32A -RRB- mRNA in platelets and megakaryoblastic cell line -LRB- Meg-01 -RRB- .
1382218	0	Fc_gamma_RIIA	107,120	Fc_gamma_receptor	83,100	Fc gamma RIIA	Fc gamma receptor	2212	2209	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the 5 ' - flanking transcriptional regulatory region of the human Fc_gamma_receptor gene , Fc_gamma_RIIA .
1653804	0	Fc_gamma_RIII	30,43	CD16	45,49	Fc gamma RIII	CD16	2214	2214	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	IL-4 antagonizes induction of Fc_gamma_RIII -LRB- CD16 -RRB- expression by transforming_growth_factor-beta on human monocytes .
1825220	0	Fc_gamma_RIII	12,25	CD16	27,31	Fc gamma RIII	CD16	2214	2214	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of Fc_gamma_RIII -LRB- CD16 -RRB- membrane expression and association with CD3_zeta and Fc_epsilon_RI-gamma by site-directed mutation .
1826887	0	Fc_gamma_RIII	31,44	CD16	46,50	Fc gamma RIII	CD16	2214	2214	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Platelet-induced expression of Fc_gamma_RIII -LRB- CD16 -RRB- on human monocytes .
7512596	0	Fc_gamma_RIII	36,49	CD16	51,55	Fc gamma RIII	CD16	2214	2214	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Membrane-proximal Ig-like domain of Fc_gamma_RIII -LRB- CD16 -RRB- contains residues critical for ligand binding .
8027553	0	Fc_gamma_RIII	61,74	CD16	55,59	Fc gamma RIII	CD16	2214	2214	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Neutrophil apoptosis is associated with a reduction in CD16 -LRB- Fc_gamma_RIII -RRB- expression .
8570089	0	Fc_gamma_RIII	115,128	CD16	139,143	Fc gamma RIII	CD16	2214	2214	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Detection by 4-parameter microscopic imaging and increase of rare mononuclear blood leukocyte types expressing the Fc_gamma_RIII receptor -LRB- CD16 -RRB- for immunoglobulin G in human sporadic amyotrophic_lateral_sclerosis -LRB- ALS -RRB- .
11123272	0	Fc_gamma_RIII	50,63	CD3_zeta	67,75	Fc gamma RIII	CD3 zeta	14131(Tax:10090)	12503(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of expression and function of Fc_gamma_RIII by CD3_zeta in murine NK cells .
8724651	0	Fc_gamma_RIII	46,59	CD_16	61,66	Fc gamma RIII	CD 16	2214	2214	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Extremely_low_birth_weight infants have lower Fc_gamma_RIII -LRB- CD_16 -RRB- plasma levels and their PMN produce less Fc_gamma_RIII compared to adults .
7515890	0	Fc_gamma_RIII	133,146	CR3	0,3	Fc gamma RIII	CR3	2214	6998	Gene	Gene	requirement|nmod|START_ENTITY END_ENTITY|dep|requirement	CR3 -LRB- Mac-1 , _ alpha_M_beta_2 , CD11b/CD18 -RRB- and Fc_gamma_RIII cooperate in generation of a neutrophil respiratory burst : requirement for Fc_gamma_RIII and tyrosine phosphorylation .
1311348	0	Fc_gamma_RIII	32,45	IFN-gamma	0,9	Fc gamma RIII	IFN-gamma	2214	3458	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IFN-gamma induces expression of Fc_gamma_RIII -LRB- CD16 -RRB- on human eosinophils .
2139455	0	Fc_gamma_RIII	23,36	transforming_growth_factor-beta	59,90	Fc gamma RIII	transforming growth factor-beta	2214	7040	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Selective induction of Fc_gamma_RIII on human monocytes by transforming_growth_factor-beta .
8405050	0	Fc_gamma_RIIIA	59,73	CD16	74,78	Fc gamma RIIIA	CD16	2214	2214	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Association of the p56lck protein tyrosine kinase with the Fc_gamma_RIIIA / CD16 complex in human natural killer cells .
8720131	0	Fc_gamma_RIIIA	103,117	HS1	19,22	Fc gamma RIIIA	HS1	2214	15163(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of HS1 , GAP-associated p190 and a novel GAP-associated p60 protein by cross-linking of Fc_gamma_RIIIA .
9798027	0	Fc_gamma_RIIa	21,34	CD32	36,40	Fc gamma RIIa	CD32	2212	2212	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of human Fc_gamma_RIIa -LRB- CD32 -RRB- polymorphism with susceptibility to and severity of meningococcal_disease .
1402657	0	Fc_gamma_RIb	90,102	Fc_gamma_receptor	66,83	Fc gamma RIb	Fc gamma receptor	2210	2209	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Definition of interferon_gamma-response elements in a novel human Fc_gamma_receptor gene -LRB- Fc_gamma_RIb -RRB- and characterization of the gene structure .
2141002	0	Fc_gamma_receptor	15,32	CD16	34,38	Fc gamma receptor	CD16	2209	2214	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	-LSB- Activation of Fc_gamma_receptor -LRB- CD16 -RRB- positive natural killer cells by rheumatoid factors in rheumatoid_arthritis -RSB- .
8612729	0	Fc_gamma_receptor	92,109	Cbl	85,88	Fc gamma receptor	Cbl	2209	867	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fc_gamma_receptor signaling .
1382218	0	Fc_gamma_receptor	83,100	Fc_gamma_RIIA	107,120	Fc gamma receptor	Fc gamma RIIA	2209	2212	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the 5 ' - flanking transcriptional regulatory region of the human Fc_gamma_receptor gene , Fc_gamma_RIIA .
1402657	0	Fc_gamma_receptor	66,83	Fc_gamma_RIb	90,102	Fc gamma receptor	Fc gamma RIb	2209	2210	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Definition of interferon_gamma-response elements in a novel human Fc_gamma_receptor gene -LRB- Fc_gamma_RIb -RRB- and characterization of the gene structure .
9686625	0	Fc_gamma_receptor	63,80	IFN-beta	23,31	Fc gamma receptor	IFN-beta	2209	3456	Gene	Gene	expression|compound|START_ENTITY action|nmod|expression action|nmod|END_ENTITY	Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc_gamma_receptor expression in healthy controls and multiple_sclerosis patients .
9103240	0	Fc_gamma_receptor	25,42	Phospholipase_D	0,15	Fc gamma receptor	Phospholipase D	2209	2822	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Phospholipase_D mediates Fc_gamma_receptor activation of neutrophils and provides specificity between high-valency_immune_complexes and fMLP signaling pathways .
9743231	0	Fc_gamma_receptor_IIIa	29,51	CD16a	53,58	Fc gamma receptor IIIa	CD16a	2214	2214	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Enhanced upregulation of the Fc_gamma_receptor_IIIa -LRB- CD16a -RRB- during in vitro differentiation of ApoE4/4 monocytes .
21264533	0	Fc_mu_receptor	18,32	FCMR	34,38	Fc mu receptor	FCMR	9214	9214	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Overexpression of Fc_mu_receptor -LRB- FCMR , TOSO -RRB- gene in chronic_lymphocytic_leukemia patients .
2955412	0	Fc_receptor	79,90	B-cell_stimulatory_factor_1	7,34	Fc receptor	B-cell stimulatory factor 1	109615(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Murine B-cell_stimulatory_factor_1 -LRB- interleukin_4 -RRB- increases expression of the Fc_receptor for IgE on mouse B cells .
26634928	0	Fc_receptor	35,46	FcRn	48,52	Fc receptor	FcRn	2217	2217	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the human neonatal Fc_receptor -LRB- FcRn -RRB- in human nasal epithelium .
27012525	0	Fc_receptor	40,51	FcRn	53,57	Fc receptor	FcRn	2217	2217	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Quantitative analysis of human neonatal Fc_receptor -LRB- FcRn -RRB- tissue expression in transgenic_mice by online peptide immuno-affinity LC-HRMS .
1493926	0	Fc_receptor	25,36	histidine-rich_glycoprotein	68,95	Fc receptor	histidine-rich glycoprotein	109615(Tax:10090)	94175(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of macrophage Fc_receptor expression and phagocytosis by histidine-rich_glycoprotein .
17117947	0	Fc_receptor-like_3	59,77	FCRL3	79,84	Fc receptor-like 3	FCRL3	115352	115352	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of the functional variant c.-169T _ > _ C of the Fc_receptor-like_3 -LRB- FCRL3 -RRB- gene in alopecia areata .
19098920	0	Fc_receptor_gamma-chain	0,23	IL-4	101,105	Fc receptor gamma-chain	IL-4	2207	3565	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|production production|compound|END_ENTITY	Fc_receptor_gamma-chain , a constitutive component of the IL-3 receptor , is required for IL-3-induced IL-4 production in basophils .
18378679	0	Fc_receptor_gamma-chain	26,49	Sp1	111,114	Fc receptor gamma-chain	Sp1	2207	6667	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Cooperative regulation of Fc_receptor_gamma-chain gene expression by multiple transcription factors , including Sp1 , GABP , and Elf-1 .
15650060	0	Fc_receptor_gamma-chain	0,23	hOSCAR	39,45	Fc receptor gamma-chain	hOSCAR	2207	126014	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Fc_receptor_gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses .
9852111	0	Fc_receptor_gamma-chain	69,92	p85	4,7	Fc receptor gamma-chain	p85	2207	5296	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc_receptor_gamma-chain and linker for activitor of T cells -LRB- LAT -RRB- in platelets stimulated by collagen and convulxin .
8218947	0	Fc_receptors	13,25	interleukin-1_beta	70,88	Fc receptors	interleukin-1 beta	109615(Tax:10090)	16176(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of Fc_receptors on murine macrophages and leukemic cells by interleukin-1_beta .
11369640	0	FcalphaR	42,50	CD89	52,56	FcalphaR	CD89	2204	2204	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Cytokine-induced inside-out activation of FcalphaR -LRB- CD89 -RRB- is mediated by a single serine residue -LRB- S263 -RRB- in the intracellular domain of the receptor .
20084080	0	Fcalpha_receptor	47,63	interleukin-10	13,27	Fcalpha receptor	interleukin-10	2204	3586	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin-10 expression through Fcalpha_receptor in human monocytes and monocyte-derived dendritic cells : role of p38_MAPKinase .
12697656	0	FcepsilonRI	20,31	Oct-1	62,67	FcepsilonRI	Oct-1	2205	6580	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of human FcepsilonRI beta chain gene expression by Oct-1 .
15153494	0	FcepsilonRI	175,186	adapter_protein	156,171	FcepsilonRI	adapter protein	2205	2533	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Differential requirement for adapter_proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion - and degranulation-promoting adapter_protein in FcepsilonRI signaling and mast cell function .
10482830	0	FcepsilonRII	63,75	CD23	77,81	FcepsilonRII	CD23	2208	2208	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression and action of the low-affinity IgE receptor FcepsilonRII -LRB- CD23 -RRB- in asthmatic airway_smooth_muscle .
20141544	0	FcepsilonRIalpha	0,16	FCER1A	23,29	FcepsilonRIalpha	FCER1A	2205	2205	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	FcepsilonRIalpha gene -LRB- FCER1A -RRB- promoter polymorphisms and total serum IgE levels in Japanese atopic_dermatitis patients .
16942574	0	FcepsilonRIalpha	51,67	IgE	46,49	FcepsilonRIalpha	IgE	2205	3497	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The alpha-chain of high-affinity receptor for IgE -LRB- FcepsilonRIalpha -RRB- gene polymorphisms and serum IgE levels .
9398286	0	FcepsilonRIalpha	68,84	IgE	42,45	FcepsilonRIalpha	IgE	2205	3497	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Identification of contact residues in the IgE binding site of human FcepsilonRIalpha .
12208673	0	FcgammaBP	51,60	IgG_Fc_binding_protein	27,49	FcgammaBP	IgG Fc binding protein	8857	8857	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of IgG_Fc_binding_protein -LRB- FcgammaBP -RRB- in human normal thyroid tissue , thyroid adenomas and thyroid_carcinomas .
10405359	0	FcgammaRI	50,59	CD64	61,65	FcgammaRI	CD64	2209	2209	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of the human high-affinity IgG receptor FcgammaRI -LRB- CD64 -RRB- on residual infectivity of neutralized dengue virus .
10519993	0	FcgammaRI	8,17	CD64	19,23	FcgammaRI	CD64	2209	2209	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of FcgammaRI -LRB- CD64 -RRB- in erythrocyte elimination and its up-regulation in thalassaemia .
16308225	0	FcgammaRI	27,36	CD64	38,42	FcgammaRI	CD64	2209	2209	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cell surface expression of FcgammaRI -LRB- CD64 -RRB- on neutrophils and monocytes in patients with influenza_A , with and without complications .
17905303	0	FcgammaRI	38,47	CD64	49,53	FcgammaRI	CD64	2209	2209	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Simultaneous quantitative analysis of FcgammaRI -LRB- CD64 -RRB- expression on neutrophils and monocytes : a new , improved way to detect infections .
18320015	0	FcgammaRI	20,29	CD64	31,35	FcgammaRI	CD64	2209	2209	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Early expression of FcgammaRI -LRB- CD64 -RRB- on monocytes of cardiac surgical patients and higher density of monocyte anti-inflammatory scavenger CD163 receptor in `` on-pump '' patients .
9613847	0	FcgammaRI	29,38	CD64	40,44	FcgammaRI	CD64	2209	2209	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	High affinity IgG binding by FcgammaRI -LRB- CD64 -RRB- is modulated by two distinct IgSF domains and the transmembrane domain of the receptor .
15075346	0	FcgammaRI	28,37	FcgammaRIIa	0,11	FcgammaRI	FcgammaRIIa	2209	2212	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	FcgammaRIIa expression with FcgammaRI results in C-reactive_protein - and IgG-mediated phagocytosis .
8662746	0	FcgammaRI	35,44	Shc	11,14	FcgammaRI	Shc	2209	6464	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Shc , Grb2 , and Raf-1 in FcgammaRI signal relay .
10671203	0	FcgammaRII	6,16	FcgammaRIII	44,55	FcgammaRII	FcgammaRIII	14130(Tax:10090)	14131(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Mouse FcgammaRII is a negative regulator of FcgammaRIII in IgG immune complex-triggered inflammation but not in autoantibody-induced hemolysis .
11719384	0	FcgammaRIIA	26,37	CD32	39,43	FcgammaRIIA	CD32	2212	2212	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The cytoplasmic domain of FcgammaRIIA -LRB- CD32 -RRB- participates in phagolysosome formation .
21605112	0	FcgammaRIIB	20,31	Fas_ligand	52,62	FcgammaRIIB	Fas ligand	2213	356	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A critical role for FcgammaRIIB in up-regulation of Fas_ligand induced by a microbial polysaccharide .
20007534	0	FcgammaRIIB	67,78	IFN_regulatory_factor_5	0,23	FcgammaRIIB	IFN regulatory factor 5	14130(Tax:10090)	27056(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	IFN_regulatory_factor_5 is required for disease development in the FcgammaRIIB - / - Yaa and FcgammaRIIB - / - mouse models of systemic_lupus_erythematosus .
10792496	0	FcgammaRIII	24,35	CD16	37,41	FcgammaRIII	CD16	2214	2214	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of FcgammaRIII -LRB- CD16 -RRB- by gammadelta T cells in patients with rheumatoid_arthritis .
10671203	0	FcgammaRIII	44,55	FcgammaRII	6,16	FcgammaRIII	FcgammaRII	14131(Tax:10090)	14130(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Mouse FcgammaRII is a negative regulator of FcgammaRIII in IgG immune complex-triggered inflammation but not in autoantibody-induced hemolysis .
14609572	0	FcgammaRIII	26,37	IL-4	0,4	FcgammaRIII	IL-4	14131(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-4 selectively enhances FcgammaRIII expression and signaling on mouse mast cells .
15659493	0	FcgammaRIIIA	17,29	CD16	31,35	FcgammaRIIIA	CD16	2214	2214	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Polymorphisms in FcgammaRIIIA -LRB- CD16 -RRB- receptor expression are associated with clinical response to rituximab in Waldenstr m 's macroglobulinemia .
10380913	0	FcgammaRIIIb	25,37	CD16	39,43	FcgammaRIIIb	CD16	2215	2214	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of neutrophil FcgammaRIIIb -LRB- CD16 -RRB- surface expression following delayed apoptosis in response to GM-CSF and sodium_butyrate .
15604023	0	FcgammaRIIa	33,44	CD32	46,50	FcgammaRIIa	CD32	2212	2212	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Flow cytometric determination of FcgammaRIIa -LRB- CD32 -RRB- polymorphism .
15075346	0	FcgammaRIIa	0,11	FcgammaRI	28,37	FcgammaRIIa	FcgammaRI	2212	2209	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	FcgammaRIIa expression with FcgammaRI results in C-reactive_protein - and IgG-mediated phagocytosis .
19201892	0	FcgammaRIIa	42,53	c-Cbl	21,26	FcgammaRIIa	c-Cbl	2212	867	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	The ubiquitin ligase c-Cbl down-regulates FcgammaRIIa activation in human neutrophils .
14613290	0	Fcgamma_receptor_IIB	28,48	CD32B	50,55	Fcgamma receptor IIB	CD32B	2213	2213	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	A novel polymorphism in the Fcgamma_receptor_IIB -LRB- CD32B -RRB- transmembrane region alters receptor signaling .
11398118	0	Fcgamma_receptor_IIa	0,20	CD32	22,26	Fcgamma receptor IIa	CD32	2212	2212	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Fcgamma_receptor_IIa -LRB- CD32 -RRB- polymorphism is associated with protection of infants against high-density Plasmodium_falciparum infection .
14740869	0	Fcgamma_receptor_IIa	15,35	CD32	37,41	Fcgamma receptor IIa	CD32	2212	2212	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of Fcgamma_receptor_IIa -LRB- CD32 -RRB- polymorphism with severe malaria in West Africa .
11904169	0	Fcp1	89,93	Pin1	0,4	Fcp1	Pin1	855320(Tax:4932)	853475(Tax:4932)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1 .
26475492	0	FcyRIIB	0,7	Btk	79,82	FcyRIIB	Btk	2213	695	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	FcyRIIB mediates antigen-independent inhibition on human B lymphocytes through Btk and p38 MAPK .
24285839	0	FcyRIIB	28,35	CD8	51,54	FcyRIIB	CD8	2213	925	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Cutting edge : Expression of FcyRIIB tempers memory CD8 T cell function in vivo .
25475856	0	FcyRIIb	0,7	VEGF-A	40,46	FcyRIIb	VEGF-A	2213	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	FcyRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis .
22698283	0	Fd3F	30,34	Rfx	51,54	Fd3F	Rfx	31336(Tax:7227)	41266(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization .
23531501	0	Fe65	39,43	AbPP	34,38	Fe65	AbPP	29722(Tax:10116)	54226(Tax:10116)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel complex AbPP : Fe65 : PP1 that regulates AbPP Thr668 phosphorylation levels .
20568118	0	Fe65	14,18	Dab1	0,4	Fe65	Dab1	322	1600	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing .
26276215	0	Fe65	0,4	Jagged1	26,33	Fe65	Jagged1	322	182	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1 .
12089154	0	Fe65	0,4	beta-amyloid_precursor_protein	34,64	Fe65	beta-amyloid precursor protein	29722(Tax:10116)	54226(Tax:10116)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Fe65 , a ligand of the Alzheimer 's beta-amyloid_precursor_protein , blocks cell cycle progression by down-regulating thymidylate_synthase expression .
10081969	0	Fe65L2	27,33	beta-amyloid_precursor_protein	75,105	Fe65L2	beta-amyloid precursor protein	10307	351	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of human Fe65L2 and its interaction with the Alzheimer 's beta-amyloid_precursor_protein .
15341744	0	Feo	0,3	PRC1	31,35	Feo	PRC1	32015(Tax:7227)	32015(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Feo , the Drosophila homolog of PRC1 , is required for central-spindle formation and cytokinesis .
19159681	0	Fer	81,84	Hsp90	0,5	Fer	Hsp90	2241	3320	Gene	Gene	activity|compound|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity .
21177873	0	Fer1L5	71,77	EHD1	29,33	Fer1L5	EHD1	90342	10938	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 -LRB- Fer1L5 -RRB- and mediate myoblast fusion .
23839945	0	Ferredoxin	0,10	frataxin	35,43	Ferredoxin	frataxin	2230	2395	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS .
16664015	0	Ferredoxin-NADP_Reductase	66,91	Diaphorase	28,38	Ferredoxin-NADP Reductase	Diaphorase	2232	1738	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|Activity Activity|compound|END_ENTITY	Effect of Ferredoxin on the Diaphorase Activity of Cyanobacterial Ferredoxin-NADP_Reductase .
26871431	0	Ferritin_Light_Chain	14,34	FTL	36,39	Ferritin Light Chain	FTL	2512	2512	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Ferritin_Light_Chain -LRB- FTL -RRB- Is Elevated_in_Glioblastoma , and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway .
23685131	0	Ferritin_light_chain	0,20	PEN-2	36,41	Ferritin light chain	PEN-2	2512	55851	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ferritin_light_chain interacts with PEN-2 and affects y-secretase activity .
12417338	0	Fes1	33,37	HspBP1	0,6	Fes1	HspBP1	852397(Tax:4932)	23640	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	HspBP1 , a homologue of the yeast Fes1 and Sls1 proteins , is an Hsc70 nucleotide exchange factor .
10788627	0	Fet3	107,111	ferroxidase	58,69	Fet3	ferroxidase	855080(Tax:4932)	851437(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The essential role of Glu-185 and Tyr-354 residues in the ferroxidase activity of Saccharomyces_cerevisiae Fet3 .
26476373	0	Fetuin-A	30,38	AHSG	40,44	Fetuin-A	AHSG	197	197	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	FGF23-regulated production of Fetuin-A -LRB- AHSG -RRB- in osteocytes .
21285371	0	Fezf2	24,29	TBR1	0,4	Fezf2	TBR1	55079	10716	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract .
12913069	0	Fgd1	0,4	cortactin	84,93	Fgd1	cortactin	14163(Tax:10090)	13043(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fgd1 , the Cdc42 GEF responsible for Faciogenital_Dysplasia , directly interacts with cortactin and mAbp1 to modulate cell shape .
7892260	0	Fgf-3	126,131	int-2	120,125	Fgf-3	int-2	14174(Tax:10090)	14174(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|amod|END_ENTITY	Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2 / Fgf-3 transgenic_mice .
8674421	0	Fgf-4	14,19	BMP-2	48,53	Fgf-4	BMP-2	428857(Tax:9031)	378779(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb .
25109552	0	Fgf10	55,60	Etv1	0,4	Fgf10	Etv1	14165(Tax:10090)	14009(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Etv1 and Ewsr1 cooperatively regulate limb mesenchymal Fgf10 expression in response to apical ectodermal ridge-derived fibroblast growth factor signal .
23220102	0	Fgf10	55,60	Gata3	0,5	Fgf10	Gata3	14165(Tax:10090)	14462(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Gata3 directly regulates early inner ear expression of Fgf10 .
24591256	0	Fgf10	15,20	Pbx1	0,4	Fgf10	Pbx1	2255	5087	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Pbx1 activates Fgf10 in the mesenchyme of developing lungs .
22719891	0	Fgf10	57,62	fibroblast_growth_factor_10	28,55	Fgf10	fibroblast growth factor 10	14165(Tax:10090)	14165(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Characterization of a novel fibroblast_growth_factor_10 -LRB- Fgf10 -RRB- knock-in mouse line to target mesenchymal progenitors during embryonic development .
15465490	0	Fgf15	114,119	Fibroblast_growth_factor_19	14,41	Fgf15	Fibroblast growth factor 19	14170(Tax:10090)	395394(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Expression of Fibroblast_growth_factor_19 -LRB- Fgf19 -RRB- during chicken embryogenesis and eye development , compared with Fgf15 expression in the mouse .
26893347	0	Fgf16	16,21	GATA4	0,5	Fgf16	GATA4	80903(Tax:10090)	14463(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GATA4 regulates Fgf16 to promote heart repair after injury .
22833125	0	Fgf20	88,93	Ectodysplasin	0,13	Fgf20	Ectodysplasin	80857(Tax:10090)	13607(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling .
21507898	0	Fgf23	64,69	PHEX	14,18	Fgf23	PHEX	64654(Tax:10090)	18675(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor -LRB- FGFR -RRB- signaling .
10646796	0	Fgf8	17,21	En1	52,55	Fgf8	En1	396313(Tax:9031)	771008(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nmod|END_ENTITY	FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm , independent of its dorsoventral specification .
10646796	0	Fgf8	17,21	FGF10	0,5	Fgf8	FGF10	396313(Tax:9031)	395432(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	FGF10 can induce Fgf8 expression concomitantly with En1 and R-fng expression in chick limb ectoderm , independent of its dorsoventral specification .
12435361	0	Fgf8	21,25	GLI3	6,10	Fgf8	GLI3	14179(Tax:10090)	14634(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube , face , and limb bud .
17166916	0	Fgf8	23,27	Lmx1b	0,5	Fgf8	Lmx1b	14179(Tax:10090)	16917(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice .
15572144	0	Fgf8	41,45	Mkp3	0,4	Fgf8	Mkp3	2253	1848	Gene	Gene	modulator|nmod|START_ENTITY modulator|nsubj|END_ENTITY	Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer .
15358670	0	Fgf8	81,85	Sp8	0,3	Fgf8	Sp8	396313(Tax:9031)	776034(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Sp8 and Sp9 , two closely related buttonhead-like transcription factors , regulate Fgf8 expression and limb outgrowth in vertebrate embryos .
19896936	0	Fgf8	33,37	Sprouty2	64,72	Fgf8	Sprouty2	396313(Tax:9031)	395584(Tax:9031)	Gene	Gene	pathway|nmod|START_ENTITY pathway|nmod|END_ENTITY	Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity .
14975726	0	Fgf8	25,29	Tbx1	37,41	Fgf8	Tbx1	14179(Tax:10090)	21380(Tax:10090)	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse .
18997112	0	Fgf8a	0,5	Wnt8	64,68	Fgf8a	Wnt8	399183(Tax:8355)	397970(Tax:8355)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm .
8586414	0	Fgfr3	71,76	fibroblast_growth_factor_receptor_3	34,69	Fgfr3	fibroblast growth factor receptor 3	14184(Tax:10090)	14184(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the mouse fibroblast_growth_factor_receptor_3 -LRB- Fgfr3 -RRB- gene .
23432784	0	Fgl2	18,22	TNF-a	0,5	Fgl2	TNF-a	84586(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TNF-a upregulates Fgl2 expression in rat myocardial_ischemia / reperfusion injury .
14760383	0	Fhit	0,4	Mlh1	88,92	Fhit	Mlh1	2272	4292	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|amod|END_ENTITY	Fhit expression in human gastric_adenomas and intramucosal_carcinomas : correlation with Mlh1 expression and gastric phenotype .
24464917	0	Fhit	0,4	Slug	51,55	Fhit	Slug	2272	6591	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Fhit regulates EMT targets through an EGFR/Src/ERK / Slug signaling axis in human bronchial cells .
15007172	0	Fhit	0,4	Src	53,56	Fhit	Src	2272	6714	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Fhit is a physiological target of the protein kinase Src .
18319262	0	Fhit	0,4	ferredoxin_reductase	22,42	Fhit	ferredoxin reductase	2272	2232	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Fhit interaction with ferredoxin_reductase triggers generation of reactive oxygen species and apoptosis of cancer cells .
23628900	0	Fhl-1	99,104	HIF-1a	92,98	Fhl-1	HIF-1a	2273	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	MicroRNA-206 is involved in hypoxia-induced pulmonary_hypertension through targeting of the HIF-1a / Fhl-1 pathway .
20013826	0	Fhl2	0,4	Foxk1	20,25	Fhl2	Foxk1	14200(Tax:10090)	17425(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors .
23463631	0	Fiat	11,15	factor_inhibiting_ATF4-mediated_transcription	17,62	Fiat	factor inhibiting ATF4-mediated transcription	353170(Tax:10090)	353170(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Control of Fiat -LRB- factor_inhibiting_ATF4-mediated_transcription -RRB- expression by Sp family transcription factors in osteoblasts .
27059954	0	Fibrillin-1	93,104	Bone_Morphogenetic_Protein	28,54	Fibrillin-1	Bone Morphogenetic Protein	2200	649	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Activity Activity|compound|END_ENTITY	Extracellular Regulation of Bone_Morphogenetic_Protein Activity by the Microfibril Component Fibrillin-1 .
11453977	0	Fibrillin-1	0,11	FBN1	13,17	Fibrillin-1	FBN1	2200	2200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fibrillin-1 -LRB- FBN1 -RRB- gene frameshift mutations in Marfan patients : genotype-phenotype correlation .
17242066	0	Fibrillin-1	0,11	TGFbeta1	45,53	Fibrillin-1	TGFbeta1	2200	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|bioavailability bioavailability|nmod|END_ENTITY	Fibrillin-1 regulates the bioavailability of TGFbeta1 .
10903502	0	Fibrinogen	0,10	ICAM-1	29,35	Fibrinogen	ICAM-1	2244	3383	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Fibrinogen interactions with ICAM-1 -LRB- CD54 -RRB- regulate endothelial cell survival .
11509634	0	Fibrinogen	0,10	IL-8	19,23	Fibrinogen	IL-8	2244	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|compound|END_ENTITY	Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine or leukotriene_B -LRB- 4 -RRB- .
16210568	0	Fibrinogen	0,10	PAI-1	28,33	Fibrinogen	PAI-1	2244	5054	Gene	Gene	contains|nsubj|START_ENTITY contains|dobj|sites sites|amod|END_ENTITY	Fibrinogen contains cryptic PAI-1 binding sites that are exposed on binding to solid surfaces or limited proteolysis .
24661950	0	Fibrinogen	0,10	Toll-like_receptor_4	36,56	Fibrinogen	Toll-like receptor 4	2244	7099	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Fibrinogen , an endogenous ligand of Toll-like_receptor_4 , activates monocytes in pre-eclamptic patients .
7833476	0	Fibrinogen	0,10	antithrombin	53,65	Fibrinogen	antithrombin	2244	462	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Fibrinogen inhibits the heparin cofactor II-mediated antithrombin activity of dermatan sulfate .
7687894	0	Fibrinogen	0,10	interleukin-3	37,50	Fibrinogen	interleukin-3	2244	3562	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Fibrinogen potentiates the effect of interleukin-3 on early human hematopoietic progenitors .
10417339	0	Fibrinogen	0,10	monocyte_chemoattractant_protein_1	42,76	Fibrinogen	monocyte chemoattractant protein 1	2244	6347	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Fibrinogen up-regulates the expression of monocyte_chemoattractant_protein_1 in human saphenous vein endothelial cells .
19429776	0	Fibrinogen	0,10	mucin	53,58	Fibrinogen	mucin	2244	100508689	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells .
2958955	0	Fibrinogen	0,10	plasmin	85,92	Fibrinogen	plasmin	2244	5340	Gene	Gene	Haifa|compound|START_ENTITY Haifa|dep|variant variant|nmod|absence absence|nmod|effect effect|nmod|calcium calcium|nmod|degradation degradation|compound|END_ENTITY	Fibrinogen Haifa : fibrinogen variant with absence of protective effect of calcium on plasmin degradation of gamma chains .
9184396	0	Fibrinogen	0,10	plasmin	92,99	Fibrinogen	plasmin	2244	5340	Gene	Gene	I|amod|START_ENTITY I|dep|evidence evidence|dep|involved involved|nsubjpass|END_ENTITY	Fibrinogen heterogeneity in homozygous plasminogen_deficiency type I : further evidence that plasmin is not involved in formation of LMW - and LMW ' - fibrinogen .
13359405	1	Fibrinogen	66,76	thrombin	78,86	Fibrinogen	thrombin	2244	2147	Gene	Gene	START_ENTITY|appos|albumin albumin|compound|END_ENTITY	I. Fibrinogen , thrombin and plasma albumin .
1670992	0	Fibrinogen	0,10	thrombin	30,38	Fibrinogen	thrombin	2244	2147	Gene	Gene	deposition|nsubj|START_ENTITY deposition|nmod|generation generation|compound|END_ENTITY	Fibrinogen deposition without thrombin generation in primary human breast_cancer tissue .
2588959	0	Fibrinogen	0,10	thrombin	163,171	Fibrinogen	thrombin	2244	2147	Gene	Gene	Sapporo|compound|START_ENTITY Sapporo|dep|dysfibrinogenemia dysfibrinogenemia|acl|characterized characterized|nmod|replacement replacement|nmod|arginine-16_by_histidine arginine-16_by_histidine|nmod|release release|nmod|A A|nmod|END_ENTITY	Fibrinogen Sapporo : dysfibrinogenemia characterized by the replacement of A alpha arginine-16_by_histidine resulting in the delayed release of fibrinopeptide A by thrombin .
6236859	0	Fibrinogen	0,10	thrombin	131,139	Fibrinogen	thrombin	2244	2147	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|factor factor|nmod|complex complex|acl:relcl|stimulated stimulated|nmod|END_ENTITY	Fibrinogen competes with von_Willebrand factor for binding to the glycoprotein IIb/IIIa complex when platelets are stimulated with thrombin .
8091386	0	Fibrinogen	0,10	thrombin	40,48	Fibrinogen	thrombin	2244	2147	Gene	Gene	levels|amod|START_ENTITY levels|nmod|marker marker|nmod|activation activation|compound|END_ENTITY	Fibrinogen plasma levels as a marker of thrombin activation : new insights on the role of fibrinogen as a cardiovascular_risk factor .
8314016	0	Fibrinogen	0,10	thrombin	40,48	Fibrinogen	thrombin	2244	2147	Gene	Gene	levels|amod|START_ENTITY levels|nmod|marker marker|nmod|activation activation|compound|END_ENTITY	Fibrinogen plasma levels as a marker of thrombin activation in diabetes .
989630	0	Fibrinogen	0,10	thrombin	73,81	Fibrinogen	thrombin	2244	2147	Gene	Gene	START_ENTITY|dep|cofactors cofactors|nmod|generation generation|nmod|END_ENTITY	Fibrinogen and its derivatives : cofactors in the intrinsic generation of thrombin .
11734667	0	Fibrinogen	0,10	tumor_necrosis_factor-alpha	48,75	Fibrinogen	tumor necrosis factor-alpha	2244	7124	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Fibrinogen increases lipopolysaccharide-induced tumor_necrosis_factor-alpha and interleukin-8 release , and enhances tissue factor activity in monocytes in a modified whole blood system .
25331442	0	Fibroblast_Activation_Protein_Alpha	22,57	FAP	59,62	Fibroblast Activation Protein Alpha	FAP	2191	2191	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Stromal Expression of Fibroblast_Activation_Protein_Alpha -LRB- FAP -RRB- Predicts Platinum Resistance and Shorter Recurrence in patients with Epithelial_Ovarian_Cancer .
26120833	0	Fibroblast_Growth_Factor-2	20,46	FGF-2	48,53	Fibroblast Growth Factor-2	FGF-2	403857(Tax:9615)	403857(Tax:9615)	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|appos|END_ENTITY	Action Mechanism of Fibroblast_Growth_Factor-2 -LRB- FGF-2 -RRB- in the Promotion of Periodontal Regeneration in Beagle_Dogs .
26682010	0	Fibroblast_Growth_Factor-9	0,26	c-Kit	37,42	Fibroblast Growth Factor-9	c-Kit	14180(Tax:10090)	16590(Tax:10090)	Gene	Gene	Activates|nsubj|START_ENTITY Activates|dobj|Cells Cells|amod|END_ENTITY	Fibroblast_Growth_Factor-9 Activates c-Kit Progenitor Cells and Enhances Angiogenesis in the Infarcted Diabetic Heart .
25533462	0	Fibroblast_Growth_Factor_2	56,82	ATP1A1	18,24	Fibroblast Growth Factor 2	ATP1A1	2247	476	Gene	Gene	Secretion|nmod|START_ENTITY Role|nmod|Secretion Role|nmod|END_ENTITY	A Direct Role for ATP1A1 in Unconventional Secretion of Fibroblast_Growth_Factor_2 .
26133178	0	Fibroblast_Growth_Factor_21	8,35	FGF21	37,42	Fibroblast Growth Factor 21	FGF21	56636(Tax:10090)	56636(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Fibroblast_Growth_Factor_21 -LRB- FGF21 -RRB- in the regulation of statural growth .
26947074	0	Fibroblast_Growth_Factor_21	0,27	JNK	68,71	Fibroblast Growth Factor 21	JNK	56636(Tax:10090)	26419(Tax:10090)	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Fibroblast_Growth_Factor_21 Mediates Glycemic Regulation by Hepatic JNK .
25475745	0	Fibroblast_Growth_Factor_23	71,98	Klotho	8,14	Fibroblast Growth Factor 23	Klotho	64654(Tax:10090)	16591(Tax:10090)	Gene	Gene	Independently|nmod|START_ENTITY Protects|nmod|Independently Protects|nsubj|END_ENTITY	Soluble Klotho Protects against Uremic_Cardiomyopathy Independently of Fibroblast_Growth_Factor_23 and Phosphate .
25429350	0	Fibroblast_Growth_Factor_Binding_Protein-1	25,67	FGFBP1	69,75	Fibroblast Growth Factor Binding Protein-1	FGFBP1	9982	9982	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of a Secreted Fibroblast_Growth_Factor_Binding_Protein-1 -LRB- FGFBP1 -RRB- in Angioproliferative Kaposi_Sarcoma .
27015635	0	Fibroblast_Growth_Factor_Receptor_1	22,57	FGFR1	59,64	Fibroblast Growth Factor Receptor 1	FGFR1	79114(Tax:10116)	79114(Tax:10116)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the Fibroblast_Growth_Factor_Receptor_1 -LRB- FGFR1 -RRB- in a Model of Spinal_Cord_Injury in Rats .
23613863	0	Fibroblast_Growth_Factor_Receptor_2	15,50	TNFa	0,4	Fibroblast Growth Factor Receptor 2	TNFa	2263	7124	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	TNFa modulates Fibroblast_Growth_Factor_Receptor_2 gene expression through the pRB/E2F1 pathway : identification of a non-canonical E2F binding motif .
27091807	0	Fibroblast_Growth_Factor_Receptor_3	23,58	FGFR3	60,65	Fibroblast Growth Factor Receptor 3	FGFR3	2261	2261	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	Tumor Heterogeneity of Fibroblast_Growth_Factor_Receptor_3 -LRB- FGFR3 -RRB- Mutations in Invasive Bladder_Cancer : Implications for Peri-Operative anti-FGFR3 Treatment .
25046247	0	Fibroblast_activation_protein	0,29	b-catenin	102,111	Fibroblast activation protein	b-catenin	2191	1499	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Fibroblast_activation_protein protects bortezomib-induced apoptosis in multiple myeloma cells through b-catenin signaling pathway .
10229820	0	Fibroblast_growth_factor-1	0,26	IL-2	44,48	Fibroblast growth factor-1	IL-2	2246	3558	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- enhances IL-2 production and nuclear translocation of NF-kappaB in FGF_receptor-bearing Jurkat T cells .
10229820	0	Fibroblast_growth_factor-1	0,26	NF-kappaB	89,98	Fibroblast growth factor-1	NF-kappaB	2246	4790	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- enhances IL-2 production and nuclear translocation of NF-kappaB in FGF_receptor-bearing Jurkat T cells .
15870071	0	Fibroblast_growth_factor-1	0,26	heme_oxygenase-1	35,51	Fibroblast growth factor-1	heme oxygenase-1	25317(Tax:10116)	24451(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Fibroblast_growth_factor-1 induces heme_oxygenase-1 via nuclear factor erythroid 2-related factor 2 -LRB- Nrf2 -RRB- in spinal cord astrocytes : consequences for motor neuron survival .
14673954	0	Fibroblast_growth_factor-1	0,26	membrane_type-1_matrix_metalloproteinase	53,93	Fibroblast growth factor-1	membrane type-1 matrix metalloproteinase	2246	4323	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Fibroblast_growth_factor-1 transcriptionally induces membrane_type-1_matrix_metalloproteinase expression in prostate_carcinoma cell line .
21518765	0	Fibroblast_growth_factor-12	0,27	FGF12	29,34	Fibroblast growth factor-12	FGF12	170630(Tax:10116)	170630(Tax:10116)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Fibroblast_growth_factor-12 -LRB- FGF12 -RRB- translocation into intestinal epithelial cells is dependent on a novel cell-penetrating peptide domain : involvement of internalization in the in vivo role of exogenous FGF12 .
22227366	0	Fibroblast_growth_factor-2	0,26	Akt1	94,98	Fibroblast growth factor-2	Akt1	2247	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|amod|END_ENTITY	Fibroblast_growth_factor-2 promotes in vitro heart valve interstitial cell repair through the Akt1 pathway .
11180398	0	Fibroblast_growth_factor-2	0,26	N-cadherin	45,55	Fibroblast growth factor-2	N-cadherin	2247	1000	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts .
19903460	0	Fibroblast_growth_factor-2	0,26	Runx2	72,77	Fibroblast growth factor-2	Runx2	2247	860	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Fibroblast_growth_factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells .
16884713	0	Fibroblast_growth_factor-2	0,26	Src	53,56	Fibroblast growth factor-2	Src	14173(Tax:10090)	20779(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Fibroblast_growth_factor-2 induces the activation of Src through Fes , which regulates focal_adhesion disassembly .
23271288	0	Fibroblast_growth_factor-2	0,26	ciliary_neurotrophic_factor	53,80	Fibroblast growth factor-2	ciliary neurotrophic factor	2247	1270	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|effect effect|nmod|END_ENTITY	Fibroblast_growth_factor-2 counteracts the effect of ciliary_neurotrophic_factor on spontaneous differentiation in adult hippocampal progenitor cells .
12093153	0	Fibroblast_growth_factor-2	0,26	glial-cell-line-derived_neurotrophic_factor	36,79	Fibroblast growth factor-2	glial-cell-line-derived neurotrophic factor	2247	2668	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Fibroblast_growth_factor-2 requires glial-cell-line-derived_neurotrophic_factor for exerting its neuroprotective actions on glutamate-lesioned hippocampal neurons .
15502643	0	Fibroblast_growth_factor-2	0,26	interleukin-6	38,51	Fibroblast growth factor-2	interleukin-6	2247	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Fibroblast_growth_factor-2 stimulates interleukin-6 secretion in human pancreatic periacinar myofibroblasts .
14593115	0	Fibroblast_growth_factor-2	0,26	platelet-derived_growth_factor_receptor-alpha	37,82	Fibroblast growth factor-2	platelet-derived growth factor receptor-alpha	2247	5156	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	Fibroblast_growth_factor-2 represses platelet-derived_growth_factor_receptor-alpha -LRB- PDGFR-alpha -RRB- transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter .
11716516	0	Fibroblast_growth_factor-2	0,26	ribosomal_protein_S19	47,68	Fibroblast growth factor-2	ribosomal protein S19	2247	6223	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fibroblast_growth_factor-2 interacts with free ribosomal_protein_S19 .
9647657	0	Fibroblast_growth_factor-2	0,26	vascular_endothelial_growth_factor	43,77	Fibroblast growth factor-2	vascular endothelial growth factor	14173(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the endothelial cells of forming capillaries : an autocrine mechanism contributing to angiogenesis .
22378787	0	Fibroblast_growth_factor-21	0,27	low-density_lipoprotein_receptor	46,78	Fibroblast growth factor-21	low-density lipoprotein receptor	26291	3949	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Fibroblast_growth_factor-21 -LRB- FGF21 -RRB- regulates low-density_lipoprotein_receptor -LRB- LDLR -RRB- levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 -LRB- Cnpy2 -RRB- / Mylip-interacting saposin-like protein -LRB- Msap -RRB- .
17911404	0	Fibroblast_growth_factor-23	0,27	parathyroid_hormone	38,57	Fibroblast growth factor-23	parathyroid hormone	530239(Tax:9913)	5741	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Fibroblast_growth_factor-23 regulates parathyroid_hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells .
15465490	0	Fibroblast_growth_factor_19	14,41	Fgf15	114,119	Fibroblast growth factor 19	Fgf15	395394(Tax:9031)	14170(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Expression of Fibroblast_growth_factor_19 -LRB- Fgf19 -RRB- during chicken embryogenesis and eye development , compared with Fgf15 expression in the mouse .
15963259	0	Fibroblast_growth_factor_2	25,51	FGF-2	53,58	Fibroblast growth factor 2	FGF-2	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Age-dependent changes in Fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- expression in mouse cerebellar neurons .
8613727	0	Fibroblast_growth_factor_2	0,26	Otx2	37,41	Fibroblast growth factor 2	Otx2	2247	5015	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Fibroblast_growth_factor_2 increases Otx2 expression in precursor cells from mammalian telencephalon .
9808840	0	Fibroblast_growth_factor_2	0,26	PLC-gamma1	32,42	Fibroblast growth factor 2	PLC-gamma1	2247	5335	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Fibroblast_growth_factor_2 uses PLC-gamma1 for cell proliferation and PI3-kinase for alteration of cell shape and cell proliferation in corneal endothelial cells .
19913500	0	Fibroblast_growth_factor_2	0,26	activating_transcription_factor_4	62,95	Fibroblast growth factor 2	activating transcription factor 4	14173(Tax:10090)	11911(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Fibroblast_growth_factor_2 positively regulates expression of activating_transcription_factor_4 in osteoblasts .
16466682	0	Fibroblast_growth_factor_2	0,26	bone_sialoprotein	67,84	Fibroblast growth factor 2	bone sialoprotein	2247	3381	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Fibroblast_growth_factor_2 and cyclic_AMP synergistically regulate bone_sialoprotein gene expression .
21939780	0	Fibroblast_growth_factor_2	0,26	syndecan-4	70,80	Fibroblast growth factor 2	syndecan-4	100550388	100126249(Tax:9103)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|modulation modulation|amod|END_ENTITY	Fibroblast_growth_factor_2 and protein_kinase_C_alpha are involved in syndecan-4 cytoplasmic domain modulation of turkey myogenic satellite cell proliferation .
17038665	0	Fibroblast_growth_factor_2	0,26	transforming_growth_factor_beta	37,68	Fibroblast growth factor 2	transforming growth factor beta	14173(Tax:10090)	7040	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Fibroblast_growth_factor_2 modulates transforming_growth_factor_beta signaling in mouse embryonic fibroblasts and human ESCs -LRB- hESCs -RRB- to support hESC self-renewal .
11204275	0	Fibroblast_growth_factor_2	0,26	vascular_endothelial_growth_factor	54,88	Fibroblast growth factor 2	vascular endothelial growth factor	2247	7422	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nsubj|activation	Fibroblast_growth_factor_2 activation of stromal cell vascular_endothelial_growth_factor expression and angiogenesis .
22342445	0	Fibroblast_growth_factor_20	0,27	FGF20	29,34	Fibroblast growth factor 20	FGF20	26281	26281	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Fibroblast_growth_factor_20 -LRB- FGF20 -RRB- polymorphism is a risk factor for Parkinson 's _ disease in Chinese population .
24942208	0	Fibroblast_growth_factor_20	0,27	FGF20	29,34	Fibroblast growth factor 20	FGF20	26281	26281	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fibroblast_growth_factor_20 -LRB- FGF20 -RRB- gene polymorphism and risk of Parkinson 's _ disease : a meta-analysis .
21926274	0	Fibroblast_growth_factor_21	0,27	FGF21	91,96	Fibroblast growth factor 21	FGF21	26291	26291	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Fibroblast_growth_factor_21 -LRB- FGF21 -RRB- in human cerebrospinal fluid : relationship with plasma FGF21 and body adiposity .
27010621	0	Fibroblast_growth_factor_21	0,27	activating_transcription_factor_4	41,74	Fibroblast growth factor 21	activating transcription factor 4	26291	468	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Fibroblast_growth_factor_21 induction by activating_transcription_factor_4 is regulated through three amino acid response elements in its promoter region .
24088960	0	Fibroblast_growth_factor_23	0,27	Klotho	99,105	Fibroblast growth factor 23	Klotho	170583(Tax:10116)	83504(Tax:10116)	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|absence absence|nmod|deficiency deficiency|compound|END_ENTITY	Fibroblast_growth_factor_23 accelerates phosphate-induced vascular_calcification in the absence of Klotho deficiency .
25402964	0	Fibroblast_growth_factor_23	0,27	klotho	28,34	Fibroblast growth factor 23	klotho	8074	9365	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Fibroblast_growth_factor_23 / klotho axis in chronic_kidney_disease .
18566132	0	Fibroblast_growth_factor_8	0,26	fibroblast_growth_factor_receptor_1	45,80	Fibroblast growth factor 8	fibroblast growth factor receptor 1	14179(Tax:10090)	14182(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Fibroblast_growth_factor_8 signaling through fibroblast_growth_factor_receptor_1 is required for the emergence of gonadotropin-releasing hormone neurons .
20370578	0	Fibroblast_growth_factor_8	0,26	thrombospondin_1	53,69	Fibroblast growth factor 8	thrombospondin 1	2253	7057	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Fibroblast_growth_factor_8 induced downregulation of thrombospondin_1 is mediated by the MEK/ERK and PI3K pathways in breast_cancer cells .
24603862	0	Fibroblast_growth_factor_9	0,26	akt	37,40	Fibroblast growth factor 9	akt	14180(Tax:10090)	11651(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|pathways pathways|compound|END_ENTITY	Fibroblast_growth_factor_9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells .
23097049	0	Fibroblast_growth_factor_homologous_factor_1	0,44	NEMO	60,64	Fibroblast growth factor homologous factor 1	NEMO	2257	8517	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Fibroblast_growth_factor_homologous_factor_1 interacts with NEMO to regulate NF-kB signaling in neurons .
17901128	0	Fibroblast_growth_factor_receptor_1	0,35	FGFR1	37,42	Fibroblast growth factor receptor 1	FGFR1	2260	2260	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Fibroblast_growth_factor_receptor_1 -LRB- FGFR1 -RRB- tyrosine phosphorylation regulates binding of FGFR_substrate_2alpha -LRB- FRS2alpha -RRB- but not FRS2 to the receptor .
25249657	0	Fibroblast_growth_factor_receptor_1	0,35	TGFb	58,62	Fibroblast growth factor receptor 1	TGFb	2260	7040	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Fibroblast_growth_factor_receptor_1 is a key inhibitor of TGFb signaling in the endothelium .
17441958	0	Fibroblast_growth_factor_receptor_3	0,35	FGFR3	37,42	Fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- mutation in a verrucous_epidermal_naevus associated with mild facial_dysmorphism .
22034009	0	Fibroblast_growth_factor_receptor_4	0,35	FGFR4	42,47	Fibroblast growth factor receptor 4	FGFR4	2264	2264	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fibroblast_growth_factor_receptor_4 gene -LRB- FGFR4 -RRB- 388Arg allele predicts prolonged survival and platinum sensitivity in advanced ovarian_cancer .
7593222	0	Fibroblast_growth_factor_receptors_1_and_2	0,42	fibroblast_growth_factor-4	127,153	Fibroblast growth factor receptors 1 and 2	fibroblast growth factor-4	14182;14183	14175(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Fibroblast_growth_factor_receptors_1_and_2 are differentially regulated in murine embryonal_carcinoma cells and in response to fibroblast_growth_factor-4 .
8839849	0	Fibulin-1	0,9	fibrinogen	53,63	Fibulin-1	fibrinogen	2192	2244	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|platelet_adhesion platelet_adhesion|nmod|bridge bridge|nmod|END_ENTITY	Fibulin-1 mediates platelet_adhesion via a bridge of fibrinogen .
26051800	0	Fibulin-2	0,9	TGF-beta1	60,69	Fibulin-2	TGF-beta1	282583(Tax:10116)	59086(Tax:10116)	Gene	Gene	mediator|nsubj|START_ENTITY mediator|nmod|effect effect|nmod|END_ENTITY	Fibulin-2 is a key mediator of the pro-neurogenic effect of TGF-beta1 on adult neural stem cells .
25451256	0	Fibulin-3	0,9	ALDH1	31,36	Fibulin-3	ALDH1	2202	216	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Fibulin-3 negatively regulates ALDH1 via c-MET suppression and increases y-radiation-induced sensitivity in some pancreatic_cancer cell lines .
26607280	0	Fibulin-4	0,9	TGF-b	31,36	Fibulin-4	TGF-b	58859(Tax:10090)	21803(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Fibulin-4 deficiency increases TGF-b signalling in aortic smooth muscle cells due to elevated TGF-b2 levels .
19627254	0	Fibulin-4	0,9	tropoelastin	38,50	Fibulin-4	tropoelastin	30008	2006	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts .
11805835	0	Fibulin-5	0,9	DANCE	10,15	Fibulin-5	DANCE	23876(Tax:10090)	23876(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|essential essential|nsubj|END_ENTITY	Fibulin-5 / DANCE is essential for elastogenesis in vivo .
24917111	0	Fibulin-5	0,9	FBLN5	11,16	Fibulin-5	FBLN5	10516	10516	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Fibulin-5 -LRB- FBLN5 -RRB- gene polymorphism is associated with pelvic_organ_prolapse .
16837650	0	Fibulin-5	0,9	TGF-beta	68,76	Fibulin-5	TGF-beta	10516	7040	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity .
26095157	0	Fibulin-5	0,9	integrin_beta-1	65,80	Fibulin-5	integrin beta-1	10516	3688	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Fibulin-5 regulates keloid-derived fibroblast-like cells through integrin_beta-1 .
12021267	1	Fibulin-5	98,107	transforming_growth_factor-beta	122,153	Fibulin-5	transforming growth factor-beta	10516	7040	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Fibulin-5 is induced by transforming_growth_factor-beta and affects protein kinase cascades .
25548290	0	Fibulin_3	24,33	p38	0,3	Fibulin 3	p38	2202	1432	Gene	Gene	Expression|compound|START_ENTITY Expression|amod|END_ENTITY	p38 MAPK Down-regulates Fibulin_3 Expression through Methylation of Gene Regulatory Sequences : ROLE IN MIGRATION AND INVASION .
21926999	0	FilGAP	46,52	filamin_A	77,86	FilGAP	filamin A	83478	2316	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin_A .
24205360	0	Filamin-A	0,9	RhoA	57,61	Filamin-A	RhoA	192176(Tax:10090)	11848(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis .
25944616	0	Filamin_A	0,9	Akt	29,32	Filamin A	Akt	2316	207	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Filamin_A phosphorylation by Akt promotes cell migration in response to arsenic .
25944616	0	Filamin_A	0,9	Akt	29,32	Filamin A	Akt	2316	207	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Filamin_A phosphorylation by Akt promotes cell migration in response to arsenic .
17408621	0	Filamin_A	40,49	Cdk1	10,14	Filamin A	Cdk1	2316	983	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cyclin_B1 / Cdk1 binds and phosphorylates Filamin_A and regulates its ability to cross-link actin .
26554816	0	Filamin_A	0,9	MKL1	41,45	Filamin A	MKL1	2316	57591	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Filamin_A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration .
24390612	0	Filamin_A	0,9	MMP-9	20,25	Filamin A	MMP-9	2316	4318	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Filamin_A regulates MMP-9 expression and suppresses prostate_cancer cell migration and invasion .
25352621	0	Filamin_A	23,32	RNase_L	0,7	Filamin A	RNase L	2316	6041	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	RNase_L Interacts with Filamin_A To Regulate Actin Dynamics and Barrier Function for Viral Entry .
24551245	0	Filamin_B	0,9	Cdk1	74,78	Filamin B	Cdk1	2317	983	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Filamin_B regulates chondrocyte proliferation and differentiation through Cdk1 signaling .
20808917	0	Filamin_a	0,9	CCR2B	19,24	Filamin a	CCR2B	2316	729230	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Filamin_a binds to CCR2B and regulates its internalization .
22649246	0	Filamin_a	0,9	Cdk1	93,97	Filamin a	Cdk1	2316	983	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Filamin_a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation .
27068241	0	Fimbrin	0,7	Cdk1	37,41	Fimbrin	Cdk1	851707(Tax:4932)	852457(Tax:4932)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast .
22871147	0	Fis1	45,49	DJ-1	0,4	Fis1	DJ-1	66437(Tax:10090)	57320(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	DJ-1 promotes the proteasomal degradation of Fis1 : implications of DJ-1 in neuronal protection .
22510686	0	Fis1	58,62	miR-484	0,7	Fis1	miR-484	66437(Tax:10090)	723916(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR-484 regulates mitochondrial network through targeting Fis1 .
10409713	0	Fiz1	0,4	Flt3	80,84	Fiz1	Flt3	23877(Tax:10090)	14255(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|acl|interacting interacting|nmod|END_ENTITY	Fiz1 , a novel zinc finger protein interacting with the receptor_tyrosine_kinase Flt3 .
12566383	0	Fiz1	118,122	NRL	49,52	Fiz1	NRL	84922	4901	Gene	Gene	role|nmod|START_ENTITY Interaction|dep|role Interaction|nmod|END_ENTITY	Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1 : possible role of Fiz1 as a transcriptional repressor .
11574398	0	Fizz3	11,16	Resistin	0,8	Fizz3	Resistin	56729	56729	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Resistin / Fizz3 expression in relation to obesity and peroxisome_proliferator-activated_receptor-gamma action in humans .
20605780	0	Fkbp52	0,6	androgen_receptor	17,34	Fkbp52	androgen receptor	14228(Tax:10090)	11835(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Fkbp52 regulates androgen_receptor transactivation activity and male urethra morphogenesis .
12865300	0	Fkh2p	65,70	CLB	117,120	Fkh2p	CLB	2290	171425	Gene	Gene	activity|compound|START_ENTITY domain|nmod|activity Ndd1p|nmod|domain Recruitment|nmod|Ndd1p Recruitment|dep|mechanism mechanism|nmod|activation activation|compound|END_ENTITY	Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity : a mechanism for CLB cluster gene activation .
12865300	0	Fkh2p	65,70	Clb	80,83	Fkh2p	Clb	2290	171425	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity : a mechanism for CLB cluster gene activation .
11570877	0	Fkhr	87,91	Akt	124,127	Fkhr	Akt	2308	207	Gene	Gene	Foxo1|appos|START_ENTITY expression|nmod|Foxo1 regulation|nmod|expression requires|nsubj|regulation requires|xcomp|distinct distinct|nmod|END_ENTITY	Insulin regulation of gene expression through the forkhead transcription factor Foxo1 -LRB- Fkhr -RRB- requires kinases distinct from Akt .
25643332	0	Flap	49,53	Flap	5,9	Flap	Flap	241	241	Gene	Gene	Combined|nmod|START_ENTITY Combined|nsubj|END_ENTITY	Alar Flap Combined With Free Auricular Composite Flap for the Reconstruction of Nasal Alar Defect .
25643332	0	Flap	5,9	Flap	49,53	Flap	Flap	241	241	Gene	Gene	Combined|nsubj|START_ENTITY Combined|nmod|END_ENTITY	Alar Flap Combined With Free Auricular Composite Flap for the Reconstruction of Nasal Alar Defect .
14562054	0	Flap_endonuclease	44,61	FEN1	63,67	Flap endonuclease	FEN1	2237	2237	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Increased expression and no mutation of the Flap_endonuclease -LRB- FEN1 -RRB- gene in human lung_cancer .
16324215	0	Flavin_containing_monooxygenase_3	21,54	FMO3	56,60	Flavin containing monooxygenase 3	FMO3	2328	2328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the Flavin_containing_monooxygenase_3 -LRB- FMO3 -RRB- gene do not predispose to essential hypertension in Caucasians .
16484587	0	Fli-1	55,60	Endoglin	0,8	Fli-1	Endoglin	14247(Tax:10090)	13805(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Endoglin expression in the endothelium is regulated by Fli-1 , Erg , and Elf-1 acting on the promoter and a -8 - kb enhancer .
20445019	0	Fli-1	59,64	SHIP-1	25,31	Fli-1	SHIP-1	2313	3635	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis .
26900987	0	Fli-1	21,26	interleukin-27	75,89	Fli-1	interleukin-27	2313	246778	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Transcription factor Fli-1 positively regulates lipopolysaccharide-induced interleukin-27 production in macrophages .
24727028	0	Fli1	0,4	Etv2	24,28	Fli1	Etv2	14247(Tax:10090)	14008(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation .
17884818	0	Fli1	87,91	Transforming_growth_factor-beta	0,31	Fli1	Transforming growth factor-beta	2313	7040	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Transforming_growth_factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation .
21451544	0	Fli1	0,4	estrogen_receptor_a	32,51	Fli1	estrogen receptor a	14247(Tax:10090)	13982(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Fli1 is a negative regulator of estrogen_receptor_a in dermal fibroblasts .
19648242	0	FliI	69,73	ATPase	79,85	FliI	ATPase	2314	1769	Gene	Gene	START_ENTITY|appos|secretion secretion|amod|END_ENTITY	Flagellar formation in C-ring-defective mutants by overproduction of FliI , the ATPase specific for flagellar type III secretion .
19293151	0	Flightless-I	18,30	CISK	90,94	Flightless-I	CISK	2314	23678	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|substrate substrate|nmod|END_ENTITY	Identification of Flightless-I as a substrate of the cytokine-independent_survival_kinase CISK .
18588881	0	Flightless-I	0,12	CaMK-II	123,130	Flightless-I	CaMK-II	2314	818	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Flightless-I , a gelsolin family member and transcriptional regulator , preferentially binds directly to activated cytosolic CaMK-II .
20223827	0	Flightless-I	0,12	Daam1	96,101	Flightless-I	Daam1	2314	23002	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Flightless-I -LRB- Fli-I -RRB- regulates the actin assembly activity of diaphanous-related formins -LRB- DRFs -RRB- Daam1 and mDia1 in cooperation with active Rho GTPase .
21400204	0	Flightless_I	24,36	gelsolin	40,48	Flightless I	gelsolin	287375(Tax:10116)	296654(Tax:10116)	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	Decreased expression of Flightless_I , a gelsolin family member and developmental regulator , in early-gestation fetal wounds improves healing .
24055811	0	Flightless_I_homolog	0,20	ChREBP	42,48	Flightless I homolog	ChREBP	2314	51085	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Flightless_I_homolog negatively regulates ChREBP activity in cancer cells .
26083914	0	Flip	8,12	Rhodopsin	16,25	Flip	Rhodopsin	8837	6010	Gene	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Retinal Flip in Rhodopsin Activation ?
19286928	0	Flk-1	68,73	CD34	57,61	Flk-1	CD34	3791	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of putative endothelial progenitor cells -LRB- CD34 + CD133 + Flk-1 + -RRB- in endarterectomized tissue of patients with chronic thromboembolic_pulmonary_hypertension .
20117086	0	Flk-1	61,66	CD34	68,72	Flk-1	CD34	3791	947	Gene	Gene	modulates|nmod|START_ENTITY +|nsubj|modulates +|dobj|chemotaxis chemotaxis|nummod|END_ENTITY	Extracellular calcium modulates in vitro bone marrow-derived Flk-1 + CD34 + progenitor cell chemotaxis and differentiation through a calcium-sensing_receptor .
15111299	0	Flk-1	81,86	Flt-1	55,60	Flk-1	Flt-1	16542(Tax:10090)	14254(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
18504303	0	Flk-1	44,49	Flt-1	18,23	Flk-1	Flt-1	3791	2321	Gene	Gene	signaling|amod|START_ENTITY modulates|dobj|signaling modulates|nsubj|END_ENTITY	The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching .
18772315	0	Flk-1	24,29	Flt-1	8,13	Flk-1	Flt-1	16542(Tax:10090)	14254(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner .
7929268	1	Flk-1	156,161	Flt-1	139,144	Flk-1	Flt-1	3791	2321	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Potentiation of vascular_endothelial_growth_factor bioactivity , in vitro and in vivo , and high affinity binding to Flt-1 but not to Flk-1 / KDR .
9400995	0	Flk-1	78,83	Flt-1	71,76	Flk-1	Flt-1	25589(Tax:10116)	54251(Tax:10116)	Gene	Gene	KDR|compound|START_ENTITY END_ENTITY|appos|KDR	Upregulation of the angiogenic factors PlGF , VEGF and their receptors -LRB- Flt-1 , Flk-1 / KDR -RRB- by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter_hypervascularization .
10864920	0	Flk-1	112,117	KDR	118,121	Flk-1	KDR	3791	3791	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Nuclear_factor-kappaB and cAMP_response_element_binding_protein mediate opposite transcriptional effects on the Flk-1 / KDR gene promoter .
15996656	0	Flk-1	109,114	KDR	115,118	Flk-1	KDR	407170(Tax:9913)	407170(Tax:9913)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	VEGF189 stimulates endothelial cells proliferation and migration in vitro and up-regulates the expression of Flk-1 / KDR mRNA .
18383901	0	Flk-1	143,148	Kdr	149,152	Flk-1	Kdr	3791	3791	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Laryngeal_carcinoma recurrence rate and disease-free interval are related to CD105 expression but not to vascular endothelial growth factor 2 -LRB- Flk-1 / Kdr -RRB- expression .
21527748	0	Flk-1	88,93	Sca-1	95,100	Flk-1	Sca-1	16542(Tax:10090)	110454(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Acrolein inhalation prevents vascular_endothelial_growth_factor-induced mobilization of Flk-1 + / Sca-1 + cells in mice .
10066445	0	Flk-1	38,43	VEGF	0,4	Flk-1	VEGF	3791	7422	Gene	Gene	KDR|compound|START_ENTITY cells|compound|KDR translocation|nmod|cells induces|dobj|translocation induces|nsubj|END_ENTITY	VEGF induces nuclear translocation of Flk-1 / KDR , endothelial_nitric_oxide_synthase , and caveolin-1 in vascular endothelial cells .
12226078	0	Flk-1	70,75	VEGF	55,59	Flk-1	VEGF	407170(Tax:9913)	281572(Tax:9913)	Gene	Gene	START_ENTITY|amod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|dep|END_ENTITY	Transactivation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR is involved in sphingosine_1-phosphate-stimulated phosphorylation of Akt and endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- .
12549858	0	Flk-1	101,106	VEGF	34,38	Flk-1	VEGF	3791	7422	Gene	Gene	growth|compound|START_ENTITY expression|nmod|growth inhibits|dobj|expression inhibits|nsubj|antibody antibody|acl:relcl|blocks blocks|xcomp|binding binding|nsubj|END_ENTITY	A monoclonal antibody that blocks VEGF binding to VEGFR2 -LRB- KDR/Flk -1 -RRB- inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast_cancer model .
15111299	0	Flk-1	81,86	VEGF	40,44	Flk-1	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|Flt-1 Flt-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
16394178	0	Flk-1	69,74	VEGF	54,58	Flk-1	VEGF	3791	7422	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|receptor receptor|appos|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
17765237	0	Flk-1	105,110	VEGF	73,77	Flk-1	VEGF	3791	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular density and distribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor VEGFR-2 -LRB- Flk-1 -RRB- are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum .
20085636	0	Flk-1	89,94	VEGF	57,61	Flk-1	VEGF	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Higher expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor VEGFR-2 -LRB- Flk-1 -RRB- and metalloproteinase-9 -LRB- MMP-9 -RRB- in a rat model of peritoneal endometriosis is similar to cancer_diseases .
23250775	0	Flk-1	149,154	VEGF	90,94	Flk-1	VEGF	3791	7422	Gene	Gene	KDR|compound|START_ENTITY follow-up|appos|KDR follow-up|nmod|analysis analysis|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
7681362	0	Flk-1	64,69	VEGF	14,18	Flk-1	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	suggest|dobj|START_ENTITY suggest|nsubj|binding binding|compound|END_ENTITY	High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis .
16375885	0	Flk-1	25,30	VEGF-A	0,6	Flk-1	VEGF-A	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic_lung epithelial to endothelial crosstalk and branching morphogenesis .
20559689	0	Flk-1	95,100	VEGF-A	70,76	Flk-1	VEGF-A	482154(Tax:9615)	403802(Tax:9615)	Gene	Gene	study|appos|START_ENTITY study|nmod|receptor receptor|amod|END_ENTITY	Immunohistochemical study of the growth factors , aFGF , bFGF , PDGF-AB , VEGF-A and its receptor -LRB- Flk-1 -RRB- during arteriogenesis .
10893303	0	Flk-1	153,158	VEGF-R2	144,151	Flk-1	VEGF-R2	3791	3791	Gene	Gene	KDR|compound|START_ENTITY END_ENTITY|appos|KDR	Identification of substituted 3 - -LSB- -LRB- 4,5,6 , _ 7-tetrahydro-1H-indol-2-yl -RRB- methylene -RSB- -1,3 - dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 -LRB- Flk-1 / KDR -RRB- , FGF-R1 , and PDGF-Rbeta tyrosine kinases .
15111299	0	Flk-1	81,86	VEGFR-1	62,69	Flk-1	VEGFR-1	16542(Tax:10090)	14254(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|Flt-1 Flt-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
25797338	0	Flk-1	79,84	VEGF_receptor_2	62,77	Flk-1	VEGF receptor 2	16542(Tax:10090)	16542(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA , VEGF_receptor_2 -LRB- Flk-1 -RRB- mRNA , and of VEGF co-receptor neuropilin -LRB- Nrp -RRB- -1 mRNA in brain tissue of aging Tg2576 mice by in situ hybridization .
14988387	0	Flk-1	53,58	Vascular_endothelial_growth_factor	0,34	Flk-1	Vascular endothelial growth factor	407170(Tax:9913)	281572(Tax:9913)	Gene	Gene	KDR|compound|START_ENTITY END_ENTITY|appos|KDR	Vascular_endothelial_growth_factor and its receptor , Flk-1 / KDR , are cytoprotective in the extravascular compartment of the ovarian follicle .
16439710	0	Flk-1	67,72	c-Kit	60,65	Flk-1	c-Kit	3791	3815	Gene	Gene	START_ENTITY|dep|circulating circulating|dobj|+ +|amod|END_ENTITY	Granulocyte_colony-stimulating_factor-mobilized circulating c-Kit + / Flk-1 + progenitor cells regenerate endothelium and inhibit neointimal hyperplasia after vascular_injury .
16570574	0	Flk-1	21,26	c-kit	14,19	Flk-1	c-kit	3791	3815	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Expression of c-kit , Flk-1 , and Flk-2 receptors in benign and malignant_tumors of follicular epithelial origin .
17850794	0	Flk-1	14,19	c-kit	47,52	Flk-1	c-kit	3791	3815	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|expression expression|amod|END_ENTITY	VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells .
11723743	0	Flk-1	106,111	vascular_endothelial_growth_factor	14,48	Flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor KDR -LRB- kinase_domain-containing_receptor -RRB- / Flk-1 -LRB- fetal_liver_kinase-1 -RRB- as prognostic factors in human colorectal_cancer .
12378509	0	Flk-1	64,69	vascular_endothelial_growth_factor	18,52	Flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|receptor-2 receptor-2|compound|END_ENTITY	Expression of the vascular_endothelial_growth_factor receptor-2 / Flk-1 in breast_carcinomas : correlation with proliferation .
15111299	0	Flk-1	81,86	vascular_endothelial_growth_factor	4,38	Flk-1	vascular endothelial growth factor	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|Flt-1 Flt-1|amod|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
15681497	0	Flk-1	83,88	vascular_endothelial_growth_factor	33,67	Flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Enhanced bronchial expression of vascular_endothelial_growth_factor and receptors -LRB- Flk-1 and Flt-1 -RRB- in patients with chronic_obstructive_pulmonary_disease .
16394178	0	Flk-1	69,74	vascular_endothelial_growth_factor	18,52	Flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16786328	0	Flk-1	88,93	vascular_endothelial_growth_factor	36,70	Flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Immunohistochemical localization of vascular_endothelial_growth_factor and its receptor Flk-1 in the amphibian developing principal and accessory olfactory system .
23250775	0	Flk-1	149,154	vascular_endothelial_growth_factor	54,88	Flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	KDR|compound|START_ENTITY follow-up|appos|KDR follow-up|nmod|analysis analysis|nmod|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
9442048	0	Flk-1	70,75	vascular_endothelial_growth_factor	24,58	Flk-1	vascular endothelial growth factor	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Two functional forms of vascular_endothelial_growth_factor receptor-2 / Flk-1 mRNA are expressed in normal rat retina .
9637783	0	Flk-1	61,66	vascular_endothelial_growth_factor	14,48	Flk-1	vascular endothelial growth factor	407170(Tax:9913)	281572(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor receptor-2 -LRB- Flk-1 -RRB- expression in vascular endothelial cells .
9892193	0	Flk-1	95,100	vascular_endothelial_growth_factor	50,84	Flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	KDR|compound|START_ENTITY inhibitor|appos|KDR inhibitor|nmod|receptor receptor|compound|END_ENTITY	SU5416 is a potent and selective inhibitor of the vascular_endothelial_growth_factor receptor -LRB- Flk-1 / KDR -RRB- that inhibits tyrosine kinase catalysis , tumor vascularization , and growth of multiple tumor types .
9126979	0	Flk-2	24,29	Flt-3_ligand	30,42	Flk-2	Flt-3 ligand	14255(Tax:10090)	14256(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Differential effects of Flk-2 / Flt-3_ligand and stem_cell_factor on murine thymic progenitor cells .
14977470	0	Flk1	83,87	CD31	89,93	Flk1	CD31	3791	5175	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1 + / CD31 - / CD34 - Progenitors .
17360037	0	Flk1	44,48	CD31	51,55	Flk1	CD31	3791	5175	Gene	Gene	CD34|amod|START_ENTITY CD34|amod|END_ENTITY	Impairment in immuno-modulatory function of Flk1 -LRB- + -RRB- CD31 -LRB- - -RRB- CD34 -LRB- - -RRB- MSCs from MDS-RA patients .
12842710	0	Flk1	61,65	CD34	75,79	Flk1	CD34	3791	947	Gene	Gene	CD31|compound|START_ENTITY marrow-derived|dobj|CD31 marrow-derived|xcomp|END_ENTITY	Hemangioblastic characteristics of fetal bone marrow-derived Flk1 -LRB- + -RRB- CD31 -LRB- - -RRB- CD34 -LRB- - -RRB- cells .
14977470	0	Flk1	83,87	CD34	95,99	Flk1	CD34	3791	947	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1 + / CD31 - / CD34 - Progenitors .
25047738	0	Flk1	18,22	CD45	31,35	Flk1	CD45	16542(Tax:10090)	19264(Tax:10090)	Gene	Gene	Circulating|dobj|START_ENTITY END_ENTITY|dep|Circulating	Circulating mouse Flk1 + / c-Kit + / CD45 - cells function as endothelial progenitors cells -LRB- EPCs -RRB- and stimulate the growth of human tumor xenografts .
9435229	0	Flk1	100,104	Flt4	127,131	Flk1	Flt4	3791	2324	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor_D -LRB- VEGF-D -RRB- is a ligand for the tyrosine kinases VEGF receptor 2 -LRB- Flk1 -RRB- and VEGF receptor 3 -LRB- Flt4 -RRB- .
21068311	0	Flk1	131,135	VEGF	51,55	Flk1	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	cerebellum|nmod|START_ENTITY isoforms|nmod|cerebellum isoforms|nsubj|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Matrix-binding vascular_endothelial_growth_factor -LRB- VEGF -RRB- isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1 .
21658588	0	Flk1	68,72	VEGF	0,4	Flk1	VEGF	3791	7422	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	VEGF mediates commissural axon chemoattraction through its receptor Flk1 .
8562934	0	Flk2	67,71	FLT3	55,59	Flk2	FLT3	2322	2322	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the hematopoietic growth factor receptor FLT3 -LRB- STK-1 / Flk2 -RRB- in human leukemias .
26576674	0	Flot2	17,22	miR-449a	0,8	Flot2	miR-449a	2319	554213	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-449a targets Flot2 and inhibits gastric_cancer invasion by inhibiting TGF-b-mediated EMT .
19121286	0	Flotillin-1	0,11	caveolin-1	23,33	Flotillin-1	caveolin-1	10211	857	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells .
21909761	0	Flowering_Promoting_Factor_1	36,64	FPF1	71,75	Flowering Promoting Factor 1	FPF1	832555(Tax:3702)	832555(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Influence of over-expression of the Flowering_Promoting_Factor_1 gene -LRB- FPF1 -RRB- from Arabidopsis on wood formation in hybrid poplar -LRB- Populus tremula L. P. tremuloides Michx . -RRB- .
23912082	0	Flr1	25,29	Yap1	41,45	Flr1	Yap1	852293(Tax:4932)	855005(Tax:4932)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The MFS-type efflux pump Flr1 induced by Yap1 promotes canthin-6-one resistance in yeast .
12110003	0	Flt-1	78,83	Angiotensin_II	0,14	Flt-1	Angiotensin II	54251(Tax:10116)	24179(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Angiotensin_II regulation of vascular_endothelial_growth_factor and receptors Flt-1 and KDR/Flk -1 in cyclosporine nephrotoxicity .
10669633	0	Flt-1	49,54	Egr-1	33,38	Flt-1	Egr-1	2321	1958	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Zinc finger transcription factor Egr-1 activates Flt-1 gene expression in THP-1 cells on induction for macrophage differentiation .
15111299	0	Flt-1	55,60	Flk-1	81,86	Flt-1	Flk-1	14254(Tax:10090)	16542(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
18504303	0	Flt-1	18,23	Flk-1	44,49	Flt-1	Flk-1	2321	3791	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|signaling signaling|amod|END_ENTITY	The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching .
18772315	0	Flt-1	8,13	Flk-1	24,29	Flt-1	Flk-1	14254(Tax:10090)	16542(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Soluble Flt-1 regulates Flk-1 activation to control hematopoietic and endothelial development in an oxygen-responsive manner .
7929268	1	Flt-1	139,144	Flk-1	156,161	Flt-1	Flk-1	2321	3791	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Potentiation of vascular_endothelial_growth_factor bioactivity , in vitro and in vivo , and high affinity binding to Flt-1 but not to Flk-1 / KDR .
9400995	0	Flt-1	71,76	Flk-1	78,83	Flt-1	Flk-1	54251(Tax:10116)	25589(Tax:10116)	Gene	Gene	START_ENTITY|appos|KDR KDR|compound|END_ENTITY	Upregulation of the angiogenic factors PlGF , VEGF and their receptors -LRB- Flt-1 , Flk-1 / KDR -RRB- by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter_hypervascularization .
18631405	0	Flt-1	64,69	Fms-like_tyrosine_kinase-1	36,62	Flt-1	Fms-like tyrosine kinase-1	2321	2321	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Dinucleotide repeat polymorphism in Fms-like_tyrosine_kinase-1 -LRB- Flt-1 -RRB- gene is not associated with preeclampsia .
26002845	0	Flt-1	23,28	IFI16	0,5	Flt-1	IFI16	2321	3428	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	IFI16 mediates soluble Flt-1 and endoglin production by trophoblast cells .
9400995	0	Flt-1	71,76	PlGF	39,43	Flt-1	PlGF	54251(Tax:10116)	94203(Tax:10116)	Gene	Gene	Upregulation|dep|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of the angiogenic factors PlGF , VEGF and their receptors -LRB- Flt-1 , Flk-1 / KDR -RRB- by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter_hypervascularization .
10471394	0	Flt-1	49,54	VEGF	24,28	Flt-1	VEGF	2321	7422	Gene	Gene	receptor|compound|START_ENTITY site|nmod|receptor site|compound|END_ENTITY	Characterization of the VEGF binding site on the Flt-1 receptor .
10496528	0	Flt-1	26,31	VEGF	9,13	Flt-1	VEGF	2321	7422	Gene	Gene	VEGF|appos|START_ENTITY VEGF|nmod|END_ENTITY	VEGF via VEGF receptor-1 -LRB- Flt-1 -RRB- mimics preeclamptic plasma in inhibiting uterine blood vessel relaxation in pregnancy : implications in the pathogenesis of preeclampsia .
10815805	0	Flt-1	29,34	VEGF	13,17	Flt-1	VEGF	2321	7422	Gene	Gene	Roles|appos|START_ENTITY Roles|nmod|receptors receptors|compound|END_ENTITY	Roles of two VEGF receptors , Flt-1 and KDR , in the signal transduction of VEGF effects in human vascular endothelial cells .
10815805	0	Flt-1	29,34	VEGF	74,78	Flt-1	VEGF	2321	7422	Gene	Gene	Roles|appos|START_ENTITY Roles|nmod|transduction transduction|nmod|effects effects|amod|END_ENTITY	Roles of two VEGF receptors , Flt-1 and KDR , in the signal transduction of VEGF effects in human vascular endothelial cells .
10865839	0	Flt-1	34,39	VEGF	18,22	Flt-1	VEGF	2321	7422	Gene	Gene	Properties|appos|START_ENTITY Properties|nmod|receptors receptors|compound|END_ENTITY	Properties of two VEGF receptors , Flt-1 and KDR , in signal transduction .
12553021	0	Flt-1	75,80	VEGF	50,54	Flt-1	VEGF	2321	7422	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- Flt-1 and Flk-1 -RRB- in esophageal_squamous_cell_carcinoma .
15297261	0	Flt-1	51,56	VEGF	29,33	Flt-1	VEGF	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|receptor receptor|compound|END_ENTITY	The gene transfer of soluble VEGF type I receptor -LRB- Flt-1 -RRB- attenuates peritoneal fibrosis formation in mice but not soluble TGF-beta_type_II_receptor gene transfer .
15492987	0	Flt-1	84,89	VEGF	50,54	Flt-1	VEGF	2321	7422	Gene	Gene	-RSB-|compound|START_ENTITY vascular_endothelial_growth_factor|dep|-RSB- vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
15851564	0	Flt-1	0,5	VEGF	43,47	Flt-1	VEGF	2321	7422	Gene	Gene	intraceptors|amod|START_ENTITY inhibit|nsubj|intraceptors inhibit|dobj|expression expression|amod|END_ENTITY	Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal_neovascularization in vivo .
16530326	0	Flt-1	33,38	VEGF	47,51	Flt-1	VEGF	2321	7422	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|mRNA mRNA|compound|END_ENTITY	The ratio of membrane-bound form Flt-1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small_cell_lung_cancer .
17031660	0	Flt-1	100,105	VEGF	56,60	Flt-1	VEGF	100732326	100462897	Gene	Gene	alterations|dep|START_ENTITY alterations|nmod|expression expression|appos|END_ENTITY	Fast alterations of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and that of its receptors -LRB- Flt-1 , Flk-1 and Neuropilin -RRB- in the cochlea of guinea_pigs after moderate noise exposure .
18630531	0	Flt-1	23,28	VEGF	66,70	Flt-1	VEGF	2321	7422	Gene	Gene	VEGFR-1|appos|START_ENTITY Expression|nmod|VEGFR-1 associated|nsubjpass|Expression associated|nmod|expression expression|compound|END_ENTITY	Expression of VEGFR-1 -LRB- Flt-1 -RRB- in breast_cancer is associated with VEGF expression and with node-negative tumour stage .
18726395	0	Flt-1	70,75	VEGF	55,59	Flt-1	VEGF	2321	7422	Gene	Gene	domain|compound|START_ENTITY receptor|dobj|domain receptor|nsubj|Screening Screening|appos|END_ENTITY	Screening of human vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 domain and study on its biological activity .
19528353	0	Flt-1	51,56	VEGF	45,49	Flt-1	VEGF	2321	7422	Gene	Gene	expressions|amod|START_ENTITY expressions|amod|END_ENTITY	Decreased nephrin and GLEPP-1 , but increased VEGF , Flt-1 , and nitrotyrosine , expressions in kidney tissue sections from women with preeclampsia .
20607359	0	Flt-1	23,28	VEGF	47,51	Flt-1	VEGF	2321	7422	Gene	Gene	fragment|nmod|START_ENTITY acted|nsubj|fragment acted|nmod|receptor receptor|compound|END_ENTITY	A fusion fragment from Flt-1 and KDR , acted as VEGF decoy receptor and exhibited anti-tumor function .
21515041	0	Flt-1	56,61	VEGF	39,43	Flt-1	VEGF	2321	7422	Gene	Gene	biosensor|appos|START_ENTITY biosensor|dep|utilizing utilizing|xcomp|receptor-1 receptor-1|nsubj|END_ENTITY	A new impedimetric biosensor utilizing VEGF receptor-1 -LRB- Flt-1 -RRB- : early diagnosis of vascular_endothelial_growth_factor in breast_cancer .
21558755	0	Flt-1	15,20	VEGF	22,26	Flt-1	VEGF	2321	7422	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Flt-1 -LRB- VEGF receptor-1 -RRB- in cancer and preeclampsia .
9393862	0	Flt-1	78,83	VEGF	41,45	Flt-1	VEGF	2321	7422	Gene	Gene	receptor|compound|START_ENTITY domain|nmod|receptor complex|nmod|domain END_ENTITY|nmod|complex	Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor .
15492987	0	Flt-1	84,89	VEGF-R1	75,82	Flt-1	VEGF-R1	2321	2321	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
10554042	0	Flt-1	114,119	vascular_endothelial_growth_factor	121,155	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	Fms-like_tyrosine_kinase-1|appos|START_ENTITY Fms-like_tyrosine_kinase-1|dep|synthesis synthesis|compound|END_ENTITY	Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like_tyrosine_kinase-1 -LRB- Flt-1 -RRB- / vascular_endothelial_growth_factor receptor-1 synthesis and neoangiogenesis .
11294698	0	Flt-1	87,92	vascular_endothelial_growth_factor	42,76	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	Measurement|appos|START_ENTITY Measurement|nmod|receptor receptor|compound|END_ENTITY	Measurement of free and complexed soluble vascular_endothelial_growth_factor receptor , Flt-1 , in fluid samples : development and application of two new immunoassays .
11468554	0	Flt-1	67,72	vascular_endothelial_growth_factor	14,48	Flt-1	vascular endothelial growth factor	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptors Flt-1 and KDR/Flk -1 in chronic cyclosporine nephrotoxicity .
12454810	0	Flt-1	95,100	vascular_endothelial_growth_factor	14,48	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor , placental_growth_factor , and their receptors Flt-1 and KDR in human placenta under pathologic conditions .
12606384	0	Flt-1	72,77	vascular_endothelial_growth_factor	14,48	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|isoforms isoforms|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor isoforms and receptors Flt-1 and KDR during the peri-implantation period in the mink , Mustela vison .
12910290	0	Flt-1	14,19	vascular_endothelial_growth_factor	44,78	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	receptors|amod|START_ENTITY Expression|nmod|receptors Expression|nmod|END_ENTITY	Expression of Flt-1 and Flk-1 receptors for vascular_endothelial_growth_factor on tumor cells as a new prognostic criterion for locally advanced breast_cancer .
15192019	0	Flt-1	149,154	vascular_endothelial_growth_factor	96,130	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	promotes|xcomp|START_ENTITY promotes|nmod|transactivation transactivation|nmod|END_ENTITY	Endothelial_PAS_domain_protein_1 gene promotes angiogenesis through the transactivation of both vascular_endothelial_growth_factor and its receptor , Flt-1 .
15492987	0	Flt-1	84,89	vascular_endothelial_growth_factor	14,48	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|dep|-RSB-	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
16210956	0	Flt-1	61,66	vascular_endothelial_growth_factor	16,50	Flt-1	vascular endothelial growth factor	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Function of the vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 / KDR in the alloimmune response in vivo .
17031660	0	Flt-1	100,105	vascular_endothelial_growth_factor	20,54	Flt-1	vascular endothelial growth factor	100732326	100462897	Gene	Gene	alterations|dep|START_ENTITY alterations|nmod|expression expression|amod|END_ENTITY	Fast alterations of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and that of its receptors -LRB- Flt-1 , Flk-1 and Neuropilin -RRB- in the cochlea of guinea_pigs after moderate noise exposure .
17402857	0	Flt-1	61,66	vascular_endothelial_growth_factor	16,50	Flt-1	vascular endothelial growth factor	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Upregulation of vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 in rat hippocampus after transient forebrain_ischemia .
17409380	0	Flt-1	61,66	vascular_endothelial_growth_factor	16,50	Flt-1	vascular endothelial growth factor	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 following acute spinal_cord_contusion in rats .
17651752	0	Flt-1	73,78	vascular_endothelial_growth_factor	27,61	Flt-1	vascular endothelial growth factor	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|receptors receptors|compound|END_ENTITY	Expression and function of vascular_endothelial_growth_factor receptors -LRB- Flt-1 and Flk-1 -RRB- in vascular adventitial fibroblasts .
17854994	0	Flt-1	59,64	vascular_endothelial_growth_factor	14,48	Flt-1	vascular endothelial growth factor	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 in embryonic rat forebrain .
18726395	0	Flt-1	70,75	vascular_endothelial_growth_factor	19,53	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	domain|compound|START_ENTITY receptor|dobj|domain receptor|nsubj|Screening Screening|nmod|END_ENTITY	Screening of human vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 domain and study on its biological activity .
21515041	0	Flt-1	56,61	vascular_endothelial_growth_factor	83,117	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	biosensor|appos|START_ENTITY biosensor|dep|diagnosis diagnosis|nmod|END_ENTITY	A new impedimetric biosensor utilizing VEGF receptor-1 -LRB- Flt-1 -RRB- : early diagnosis of vascular_endothelial_growth_factor in breast_cancer .
8058332	0	Flt-1	173,178	vascular_endothelial_growth_factor	97,131	Flt-1	vascular endothelial growth factor	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	family|dep|START_ENTITY tyrosine|dobj|family tyrosine|nsubj|system system|nmod|cells cells|nmod|liver liver|nmod|END_ENTITY	A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular_endothelial_growth_factor and Flt tyrosine kinase receptor family -LRB- Flt-1 and KDR/Flk -1 -RRB- .
8822205	0	Flt-1	0,5	vascular_endothelial_growth_factor	102,136	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|factor factor|acl:relcl|related related|nmod|END_ENTITY	Flt-1 but not KDR/Flk -1 tyrosine kinase is a receptor for placenta growth factor , which is related to vascular_endothelial_growth_factor .
9452434	0	Flt-1	144,149	vascular_endothelial_growth_factor	77,111	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	START_ENTITY|dep|Mapping Mapping|nmod|domain domain|nmod|END_ENTITY	Mapping the charged residues in the second immunoglobulin-like domain of the vascular_endothelial_growth_factor / placenta_growth_factor receptor Flt-1 required for binding and structural stability .
9620838	0	Flt-1	127,132	vascular_endothelial_growth_factor	82,116	Flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular_endothelial_growth_factor receptor , Flt-1 .
12209971	0	Flt-1	107,112	vascular_endothelial_growth_factor_receptor	62,105	Flt-1	vascular endothelial growth factor receptor	2321	3791	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Autocrine_motility_factor secreted by tumor cells upregulates vascular_endothelial_growth_factor_receptor -LRB- Flt-1 -RRB- expression in endothelial cells .
7507245	0	Flt-3	34,39	STK-1	0,5	Flt-3	STK-1	2322	2322	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	STK-1 , the human homolog of Flk-2 / Flt-3 , is selectively expressed in CD34 + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells .
20829349	0	Flt-3	50,55	Stat-5	22,28	Flt-3	Stat-5	2322	6776	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells .
9126979	0	Flt-3_ligand	30,42	Flk-2	24,29	Flt-3 ligand	Flk-2	14256(Tax:10090)	14255(Tax:10090)	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Differential effects of Flk-2 / Flt-3_ligand and stem_cell_factor on murine thymic progenitor cells .
9166838	0	Flt-3_ligand	0,12	granulocyte_colony-stimulating_factor	29,66	Flt-3 ligand	granulocyte colony-stimulating factor	2323	1440	Gene	Gene	synergizes|amod|START_ENTITY synergizes|nmod|END_ENTITY	Flt-3_ligand synergizes with granulocyte_colony-stimulating_factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential .
19646499	0	Flt-4	8,13	VEGFR-3	0,7	Flt-4	VEGFR-3	14257(Tax:10090)	14257(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|appos|mediates	VEGFR-3 / Flt-4 mediates proliferation and chemotaxis in glial precursor cells .
19658040	0	Flt1	51,55	PlGF	45,49	Flt1	PlGF	2321	5228	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Mutation analysis of the growth factor genes PlGF , Flt1 , IGF-I , and IGF-IR in intrauterine_growth_restriction with abnormal placental blood flow .
26970832	0	Flt1	22,26	Relaxin-2	0,9	Flt1	Relaxin-2	2321	6019	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Relaxin-2 and Soluble Flt1 Levels in Peripartum Cardiomyopathy : Results of the Multicenter IPAC Study .
10748050	0	Flt1	47,51	vascular_endothelial_cell_growth_factor	85,124	Flt1	vascular endothelial cell growth factor	2321	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|receptor receptor|compound|END_ENTITY	Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- receptor mRNAs by VEGF .
15728461	0	Flt3	69,73	CD11b	74,79	Flt3	CD11b	14255(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Progressive and controlled development of mouse dendritic cells from Flt3 + CD11b + progenitors in vitro .
12513756	0	Flt3	26,30	CD34	55,59	Flt3	CD34	14255(Tax:10090)	12490(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Functional expression of Flt3 and c-kit on cord blood CD34 -LRB- + -RRB- stem/progenitor cells and its significance -RSB- .
10409713	0	Flt3	80,84	Fiz1	0,4	Flt3	Fiz1	14255(Tax:10090)	23877(Tax:10090)	Gene	Gene	interacting|nmod|START_ENTITY protein|acl|interacting END_ENTITY|appos|protein	Fiz1 , a novel zinc finger protein interacting with the receptor_tyrosine_kinase Flt3 .
20971928	0	Flt3	16,20	Hoxa9	0,5	Flt3	Hoxa9	14255(Tax:10090)	15405(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Hoxa9 regulates Flt3 in lymphohematopoietic progenitors .
23996689	0	Flt3	78,82	Hoxa9	0,5	Flt3	Hoxa9	14255(Tax:10090)	15405(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY collaborates|nmod|activation collaborates|nsubj|END_ENTITY	Hoxa9 collaborates with E2A-PBX1 in mouse B_cell_leukemia in association with Flt3 activation and decrease of B cell gene expression .
11672547	0	Flt3	16,20	Sca1	61,65	Flt3	Sca1	14255(Tax:10090)	12367(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of Flt3 expression within the bone marrow Lin -LRB- - -RRB- Sca1 -LRB- + -RRB- c-kit -LRB- + -RRB- stem cell compartment is accompanied by loss of self-renewal capacity .
23300935	0	Flt3	70,74	Src-Like_adaptor_protein	0,24	Flt3	Src-Like adaptor protein	2322	6503	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Src-Like_adaptor_protein -LRB- SLAP -RRB- binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling .
11672547	0	Flt3	16,20	c-kit	68,73	Flt3	c-kit	14255(Tax:10090)	16590(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Upregulation of Flt3 expression within the bone marrow Lin -LRB- - -RRB- Sca1 -LRB- + -RRB- c-kit -LRB- + -RRB- stem cell compartment is accompanied by loss of self-renewal capacity .
21539498	0	Flt3	0,4	granulocyte-colony-stimulating_factor	28,65	Flt3	granulocyte-colony-stimulating factor	140635(Tax:10116)	25610(Tax:10116)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Flt3 ligand synergizes with granulocyte-colony-stimulating_factor in bone marrow mobilization to improve functional outcome after spinal_cord_injury in the rat .
9345066	0	Flt3	0,4	granulocyte-macrophage_colony-stimulating_factor	28,76	Flt3	granulocyte-macrophage colony-stimulating factor	14255(Tax:10090)	1437	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Flt3 ligand synergizes with granulocyte-macrophage_colony-stimulating_factor or granulocyte_colony-stimulating_factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice .
16840346	0	Flt3-L	82,88	CCL20	14,19	Flt3-L	CCL20	2323	6364	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of CCL20 and granulocyte-macrophage colony-stimulating factor , but not Flt3-L , from modified vaccinia_virus ankara enhances antiviral cellular and humoral immune responses .
20731086	0	Flt3-L	89,95	GM-CSF	101,107	Flt3-L	GM-CSF	14256(Tax:10090)	12981(Tax:10090)	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Identification of mouse dentritic cells expanded in vivo by combined over-expression of Flt3-L with GM-CSF -RSB- .
24064002	0	Flt3L	46,51	Fms-like_tyrosine_kinase_3_ligand	11,44	Flt3L	Fms-like tyrosine kinase 3 ligand	14256(Tax:10090)	14256(Tax:10090)	Gene	Gene	signalling|appos|START_ENTITY signalling|compound|END_ENTITY	Absence of Fms-like_tyrosine_kinase_3_ligand -LRB- Flt3L -RRB- signalling protects against collagen-induced_arthritis .
15004163	0	Flt3_ligand	6,17	CD11c	31,36	Flt3 ligand	CD11c	14256(Tax:10090)	16411(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	Nasal Flt3_ligand cDNA elicits CD11c + CD8 + dendritic cells for enhanced mucosal immunity .
9435229	0	Flt4	127,131	Flk1	100,104	Flt4	Flk1	2324	3791	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor_D -LRB- VEGF-D -RRB- is a ligand for the tyrosine kinases VEGF receptor 2 -LRB- Flk1 -RRB- and VEGF receptor 3 -LRB- Flt4 -RRB- .
6195834	0	Fluoride-resistant_acid_phosphatase	0,35	FRAP	37,41	Fluoride-resistant acid phosphatase	FRAP	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Fluoride-resistant_acid_phosphatase -LRB- FRAP -RRB- activity of nociceptive nerve terminals in the dental pulp .
9119367	0	Fmn	18,21	formin	10,16	Fmn	formin	14260(Tax:10090)	14260(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse formin -LRB- Fmn -RRB- gene : genomic structure , novel exons , and genetic mapping .
9848078	0	Fmn	18,21	formin	10,16	Fmn	formin	14260(Tax:10090)	14260(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse formin -LRB- Fmn -RRB- gene : abundant circular RNA transcripts and gene-targeted deletion analysis .
25460299	0	Fmo3	48,52	flavin-containing_mono-oxygenase	14,46	Fmo3	flavin-containing mono-oxygenase	14262(Tax:10090)	14262(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of flavin-containing_mono-oxygenase -LRB- Fmo3 -RRB- gene expression by steroids in mice and humans .
24021279	0	Fmr1	22,26	MicroRNA-130b	0,13	Fmr1	MicroRNA-130b	14265(Tax:10090)	723816(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MicroRNA-130b targets Fmr1 and regulates embryonic neural progenitor cell proliferation and differentiation .
18631405	0	Fms-like_tyrosine_kinase-1	36,62	Flt-1	64,69	Fms-like tyrosine kinase-1	Flt-1	2321	2321	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Dinucleotide repeat polymorphism in Fms-like_tyrosine_kinase-1 -LRB- Flt-1 -RRB- gene is not associated with preeclampsia .
10554042	0	Fms-like_tyrosine_kinase-1	86,112	vascular_endothelial_growth_factor	121,155	Fms-like tyrosine kinase-1	vascular endothelial growth factor	2321	7422	Gene	Gene	START_ENTITY|dep|synthesis synthesis|compound|END_ENTITY	Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like_tyrosine_kinase-1 -LRB- Flt-1 -RRB- / vascular_endothelial_growth_factor receptor-1 synthesis and neoangiogenesis .
24064002	0	Fms-like_tyrosine_kinase_3_ligand	11,44	Flt3L	46,51	Fms-like tyrosine kinase 3 ligand	Flt3L	14256(Tax:10090)	14256(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY signalling|appos|END_ENTITY	Absence of Fms-like_tyrosine_kinase_3_ligand -LRB- Flt3L -RRB- signalling protects against collagen-induced_arthritis .
22634180	0	Fn14	23,27	EGFR	84,88	Fn14	EGFR	51330	1956	Gene	Gene	expression|nmod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Elevated expression of Fn14 in non-small_cell_lung_cancer correlates with activated EGFR and promotes tumor cell migration and invasion .
12821115	0	Fn14	51,55	TWEAK	27,32	Fn14	TWEAK	27279(Tax:10090)	21944(Tax:10090)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of murine TWEAK and its receptor -LRB- Fn14 -RRB- by monoclonal antibodies .
25869623	0	Fndc5	29,34	ERK1/2	0,6	Fndc5	ERK1/2	252995	5595;5594	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	ERK1/2 is a key regulator of Fndc5 and PGC1a expression during neural differentiation of mESCs .
24642356	0	Fndc5	47,52	irisin	60,66	Fndc5	irisin	252995	252995	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Exercise-mimicking treatment fails to increase Fndc5 mRNA _ irisin secretion in primary human myotubes .
9677325	0	Fnk	77,80	fibroblast-growth-factor-inducible_kinase	34,75	Fnk	fibroblast-growth-factor-inducible kinase	1263	1263	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and phosphorylation of fibroblast-growth-factor-inducible_kinase -LRB- Fnk -RRB- during cell-cycle progression .
22056317	0	Focal_adhesion_kinase	0,21	AKT	87,90	Focal adhesion kinase	AKT	14083(Tax:10090)	11651(Tax:10090)	Gene	Gene	governs|nsubj|START_ENTITY governs|advcl|activating activating|dobj|pathways pathways|compound|END_ENTITY	Focal_adhesion_kinase governs cardiac concentric hypertrophic growth by activating the AKT and mTOR pathways .
15166238	0	Focal_adhesion_kinase	0,21	Akt	67,70	Focal adhesion kinase	Akt	5747	207	Gene	Gene	signaling|nsubj|START_ENTITY signaling|advmod|upstream upstream|nmod|matrices matrices|amod|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|dep|I I|dep|END_ENTITY	Focal_adhesion_kinase is upstream of phosphatidylinositol_3-kinase / Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway .
18854312	0	Focal_adhesion_kinase	0,21	Akt	71,74	Focal adhesion kinase	Akt	5747	207	Gene	Gene	scaffold|nsubj|START_ENTITY scaffold|xcomp|mediating mediating|dobj|protection protection|compound|END_ENTITY	Focal_adhesion_kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection .
11315093	0	Focal_adhesion_kinase	0,21	FAK	23,26	Focal adhesion kinase	FAK	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Focal_adhesion_kinase -LRB- FAK -RRB- phosphorylation is not required for genistein-induced FAK-beta-1-integrin complex formation .
15161103	0	Focal_adhesion_kinase	0,21	FAK	23,26	Focal adhesion kinase	FAK	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Focal_adhesion_kinase -LRB- FAK -RRB- expression and phosphorylation in sea urchin embryos .
22776966	0	Focal_adhesion_kinase	0,21	NF-kB	32,37	Focal adhesion kinase	NF-kB	25614(Tax:10116)	81736(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Focal_adhesion_kinase activates NF-kB via the ERK1/2 and p38MAPK Pathways in amyloid-b25-35-induced apoptosis in PC12 cells .
21454698	0	Focal_adhesion_kinase	0,21	RET	34,37	Focal adhesion kinase	RET	5747	5979	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|kinase kinase|compound|END_ENTITY	Focal_adhesion_kinase -LRB- FAK -RRB- binds RET kinase via its FERM domain , priming a direct and reciprocal RET-FAK transactivation mechanism .
20407018	0	Focal_adhesion_kinase	0,21	Raf-1	48,53	Focal adhesion kinase	Raf-1	14083(Tax:10090)	110157(Tax:10090)	Gene	Gene	START_ENTITY|appos|mediator mediator|nmod|END_ENTITY	Focal_adhesion_kinase , a downstream mediator of Raf-1 signaling , suppresses cellular adhesion , migration , and neuroendocrine markers in BON_carcinoid cells .
11278462	0	Focal_adhesion_kinase	0,21	Stat1	32,37	Focal adhesion kinase	Stat1	14083(Tax:10090)	20846(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Focal_adhesion_kinase activates Stat1 in integrin-mediated cell migration and adhesion .
19956390	0	Focal_adhesion_kinase	0,21	akt	38,41	Focal adhesion kinase	akt	14083(Tax:10090)	11651(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|target target|amod|END_ENTITY	Focal_adhesion_kinase functions as an akt downstream target in migration of colorectal_cancer cells .
24021281	0	Focal_adhesion_kinase	0,21	b-catenin	31,40	Focal adhesion kinase	b-catenin	5747	1499	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Focal_adhesion_kinase mediates b-catenin signaling in periodontal ligament cells .
15287896	0	Focal_adhesion_kinase	0,21	cyclin_D3	50,59	Focal adhesion kinase	cyclin D3	25614(Tax:10116)	25193(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Focal_adhesion_kinase mediates endothelin-induced cyclin_D3 expression in rat cultured astrocytes .
15494733	0	Focal_adhesion_kinase	0,21	netrin-1	25,33	Focal adhesion kinase	netrin-1	5747	9423	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Focal_adhesion_kinase in netrin-1 signaling .
26251180	0	Focal_adhesion_kinase	0,21	phosphatase_and_tensin_homolog_deleted_on_chromosome_10	41,96	Focal adhesion kinase	phosphatase and tensin homolog deleted on chromosome 10	14083(Tax:10090)	19211(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Focal_adhesion_kinase phosphorylates the phosphatase_and_tensin_homolog_deleted_on_chromosome_10 under the control of p110 phosphoinositide-3 kinase .
26251180	0	Focal_adhesion_kinase	0,21	phosphatase_and_tensin_homolog_deleted_on_chromosome_10	41,96	Focal adhesion kinase	phosphatase and tensin homolog deleted on chromosome 10	14083(Tax:10090)	19211(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Focal_adhesion_kinase phosphorylates the phosphatase_and_tensin_homolog_deleted_on_chromosome_10 under the control of p110 phosphoinositide-3 kinase .
23387972	0	Focal_adhesion_kinase	0,21	thioredoxin-interacting_protein	46,77	Focal adhesion kinase	thioredoxin-interacting protein	5747	10628	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Focal_adhesion_kinase regulates expression of thioredoxin-interacting_protein -LRB- TXNIP -RRB- in cancer cells .
11502212	0	Focal_adhesion_kinase	0,21	tumor_necrosis_factor-alpha	103,130	Focal adhesion kinase	tumor necrosis factor-alpha	5747	7124	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|sensitivity sensitivity|nmod|SMMC-7721 SMMC-7721|nmod|apoptosis apoptosis|amod|END_ENTITY	Focal_adhesion_kinase affects the sensitivity of human hepatocellular_carcinoma cell line SMMC-7721 to tumor_necrosis_factor-alpha / cycloheximide-induced apoptosis by regulating protein_kinase_B levels .
12949227	0	Focal_adhesion_kinase	0,21	vascular_endothelial_growth_factor	77,111	Focal adhesion kinase	vascular endothelial growth factor	5747	7422	Gene	Gene	mediates|amod|START_ENTITY porcine|nsubj|mediates porcine|nmod|END_ENTITY	Focal_adhesion_kinase mediates porcine venular_hyperpermeability elicited by vascular_endothelial_growth_factor .
23528302	0	Folate-receptor_1	0,17	FOLR1	19,24	Folate-receptor 1	FOLR1	2348	2348	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Folate-receptor_1 -LRB- FOLR1 -RRB- protein is elevated in the serum of ovarian_cancer patients .
26667416	0	Folate_Receptor_1	41,58	Folr1	60,65	Folate Receptor 1	Folr1	171049(Tax:10116)	171049(Tax:10116)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Genetic Variation in Renal Expression of Folate_Receptor_1 -LRB- Folr1 -RRB- Gene Predisposes Spontaneously Hypertensive Rats to Metabolic_Syndrome .
23525507	0	Folliculin	0,10	cyclin_D1	103,112	Folliculin	cyclin D1	201163	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|elements elements|nmod|region region|nmod|mRNA mRNA|amod|END_ENTITY	Folliculin regulates cyclin_D1 expression through cis-acting elements in the 3 ' untranslated region of cyclin_D1 mRNA .
23525507	0	Folliculin	0,10	cyclin_D1	21,30	Folliculin	cyclin D1	201163	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Folliculin regulates cyclin_D1 expression through cis-acting elements in the 3 ' untranslated region of cyclin_D1 mRNA .
27072130	0	Folliculin	17,27	mTORC1	38,44	Folliculin	mTORC1	201163	382056(Tax:10090)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|END_ENTITY	Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia .
22965878	0	Folliculin	0,10	p0071	26,31	Folliculin	p0071	216805(Tax:10090)	227937(Tax:10090)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Folliculin interacts with p0071 -LRB- plakophilin-4 -RRB- and deficiency is associated with disordered RhoA signalling , epithelial polarization and cytokinesis .
23139756	0	Folliculin	0,10	p0071	114,119	Folliculin	p0071	201163	8502	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Folliculin , the product of the Birt-Hogg-Dube tumor suppressor gene , interacts with the adherens junction protein p0071 to regulate cell-cell adhesion .
11741284	0	Follistatin	0,11	BMP-15	63,69	Follistatin	BMP-15	24373(Tax:10116)	59302(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	Follistatin inhibits the function of the oocyte-derived factor BMP-15 .
23171678	0	Follistatin	0,11	IL-1b	26,31	Follistatin	IL-1b	10468	3553	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Follistatin is induced by IL-1b and TNF-a in stromal cells from endometrioma .
24514266	0	Follistatin	0,11	Noggin	27,33	Follistatin	Noggin	10468	9241	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Follistatin interacts with Noggin in the development of the axial skeleton .
7684983	0	Follistatin	0,11	activin	22,29	Follistatin	activin	10468	83729	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	Follistatin modulates activin activity in a cell - and tissue-specific manner .
11846481	0	Follistatin	0,11	bone_morphogenetic_protein-7	22,50	Follistatin	bone morphogenetic protein-7	396119(Tax:9031)	395494(Tax:9031)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Follistatin regulates bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- activity to stimulate embryonic muscle growth .
19533841	0	Follistatin	0,11	gonadotropin-releasing_hormone	31,61	Follistatin	gonadotropin-releasing hormone	10468	2796	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Follistatin gene expression by gonadotropin-releasing_hormone : a role for cyclic_AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph LbetaT2 cells .
23297191	0	Follistatin	0,11	notum	56,61	Follistatin	notum	10468	147111	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Follistatin antagonizes activin signaling and acts with notum to direct planarian head regeneration .
19446581	0	Follistatin	0,11	thyrotropin-releasing_hormone	24,53	Follistatin	thyrotropin-releasing hormone	24373(Tax:10116)	25569(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Follistatin , induced by thyrotropin-releasing_hormone -LRB- TRH -RRB- , plays no role in prolactin expression but affects gonadotropin FSHbeta expression as a paracrine factor in pituitary somatolactotroph GH3 cells .
20861081	0	Follistatin-like_1	0,18	IL-1b	35,40	Follistatin-like 1	IL-1b	14314(Tax:10090)	16176(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Follistatin-like_1 regulates renal IL-1b expression in cisplatin nephrotoxicity .
26365350	0	Follistatin-like_1	0,18	Smad2/3	86,93	Follistatin-like 1	Smad2/3	11167	4087;4088	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Follistatin-like_1 attenuates differentiation and survival of erythroid cells through Smad2/3 signaling .
19109154	0	Follistatin-like_protein_1	0,26	IFN-gamma	63,72	Follistatin-like protein 1	IFN-gamma	14314(Tax:10090)	15978(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Follistatin-like_protein_1 promotes arthritis by up-regulating IFN-gamma .
12970321	0	Follistatin-related_gene	0,24	FLRG	26,30	Follistatin-related gene	FLRG	10272	10272	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Follistatin-related_gene -LRB- FLRG -RRB- expression in human endometrium : sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells .
26667416	0	Folr1	60,65	Folate_Receptor_1	41,58	Folr1	Folate Receptor 1	171049(Tax:10116)	171049(Tax:10116)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Genetic Variation in Renal Expression of Folate_Receptor_1 -LRB- Folr1 -RRB- Gene Predisposes Spontaneously Hypertensive Rats to Metabolic_Syndrome .
26107232	0	Folylpolyglutamate_Synthetase	48,77	FPGS	79,83	Folylpolyglutamate Synthetase	FPGS	2356	2356	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Mutation Screening and Association Study of the Folylpolyglutamate_Synthetase -LRB- FPGS -RRB- Gene with Susceptibility to Childhood_Acute_Lymphoblastic_Leukemia .
26908052	0	Forkhead_Box_F1	0,15	lysyl_oxidase	70,83	Forkhead Box F1	lysyl oxidase	2294	4015	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Forkhead_Box_F1 promotes breast_cancer cell migration by upregulating lysyl_oxidase and suppressing Smad2/3 signaling .
14686788	0	Forkhead_Box_M1B	46,62	FoxM1B	64,70	Forkhead Box M1B	FoxM1B	14235(Tax:10090)	14235(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Rapid hepatocyte nuclear translocation of the Forkhead_Box_M1B -LRB- FoxM1B -RRB- transcription factor caused a transient increase in size of regenerating transgenic hepatocytes .
26800252	0	Forkhead_Box_O1	21,36	FoxO1	38,43	Forkhead Box O1	FoxO1	506618(Tax:9913)	506618(Tax:9913)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Associations between Forkhead_Box_O1 -LRB- FoxO1 -RRB- Expression and Indicators of Hepatic Glucose Production in Transition Dairy Cows Supplemented with Dietary Nicotinic_Acid .
25411964	0	Forkhead_Box_Protein_M1	18,41	FOXM1	43,48	Forkhead Box Protein M1	FOXM1	2305	2305	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Forkhead_Box_Protein_M1 -LRB- FOXM1 -RRB- in Ovarian_Cancer Correlates with Poor Patient Survival and Contributes to Paclitaxel Resistance .
12774021	0	Forkhead_box_A2	34,49	HNF-3beta	51,60	Forkhead box A2	HNF-3beta	15376(Tax:10090)	15376(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Elevated hepatocyte levels of the Forkhead_box_A2 -LRB- HNF-3beta -RRB- transcription factor cause postnatal steatosis and mitochondrial_damage .
25220476	0	Forkhead_box_D3	48,63	Foxd3	70,75	Forkhead box D3	Foxd3	15221(Tax:10090)	15221(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Homeobox_b5 -LRB- Hoxb5 -RRB- regulates the expression of Forkhead_box_D3 gene -LRB- Foxd3 -RRB- in neural crest .
26344694	0	Forkhead_box_K2	0,15	FOXO3a	72,78	Forkhead box K2	FOXO3a	3607	2309	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Forkhead_box_K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast_cancer .
26619071	0	Forkhead_box_M1	27,42	FOXM1	44,49	Forkhead box M1	FOXM1	2305	2305	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of Forkhead_box_M1 -LRB- FOXM1 -RRB- expression and antitumor effect of FOXM1 inhibition in melanoma .
23918930	0	Forkhead_box_O1	0,15	FOXO1	17,22	Forkhead box O1	FOXO1	56458(Tax:10090)	56458(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Forkhead_box_O1 -LRB- FOXO1 -RRB- protein , but not p53 , contributes to robust induction of p21 expression in fasted mice .
26751098	0	Forkhead_box_O3	72,87	FOXO3	89,94	Forkhead box O3	FOXO3	101799850	101799850	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , characterisation and functional analysis of the duck Forkhead_box_O3 -LRB- FOXO3 -RRB- gene .
19364305	0	Forkhead_box_P3	0,15	FOXP3	17,22	Forkhead box P3	FOXP3	50943	50943	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Forkhead_box_P3 -LRB- FOXP3 -RRB- mRNA expression immediately after living-donor liver transplant .
24792364	0	Forkhead_box_j2	21,36	MicroRNA-34a	0,12	Forkhead box j2	MicroRNA-34a	55810	407040	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-34a targets Forkhead_box_j2 to modulate differentiation of endothelial progenitor cells in response to shear stress .
23625627	0	Forkhead_box_protein_A1	0,23	uncoupling_protein_2	51,71	Forkhead box protein A1	uncoupling protein 2	3169	7351	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Forkhead_box_protein_A1 inhibits the expression of uncoupling_protein_2 in hydrogen_peroxide-induced A549 cell line .
26468278	0	Forkhead_box_protein_K1	148,171	JNK_associated_leucine_zipper_protein	0,37	Forkhead box protein K1	JNK associated leucine zipper protein	221937	9043	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	JNK_associated_leucine_zipper_protein functions as a docking platform for Polo_like_kinase_1 and regulation of the associating transcription factor Forkhead_box_protein_K1 .
25963818	0	Formin-like_2	41,54	Rac1	69,73	Formin-like 2	Rac1	114793	5879	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Junctional actin assembly is mediated by Formin-like_2 downstream of Rac1 .
21818269	0	Formin1	0,7	neurogenin3	72,83	Formin1	neurogenin3	14260(Tax:10090)	11925(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons .
17705784	0	Fortilin	0,8	Ca2	15,18	Fortilin	Ca2	7178	760	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Fortilin binds Ca2 + and blocks Ca2 + - dependent apoptosis in vivo .
10902897	0	Fos	27,30	CA1	59,62	Fos	CA1	314322(Tax:10116)	310218(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Estradiol induces a phasic Fos response in the hippocampal CA1 and CA3 regions of adult female rats .
15033432	0	Fos	42,45	CA1	83,86	Fos	CA1	314322(Tax:10116)	310218(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY induction|nmod|protein decreased|dobj|induction decreased|nmod|END_ENTITY	Nociception-driven decreased induction of Fos protein in ventral hippocampus field CA1 of the rat .
15554911	0	Fos	101,104	CA1	123,126	Fos	CA1	314322(Tax:10116)	310218(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY increase|nmod|expression associated|nmod|increase associated|nmod|hippocampus hippocampus|compound|END_ENTITY	Improvement of spatial cognition with dietary docosahexaenoic_acid is associated with an increase in Fos expression in rat CA1 hippocampus .
9372200	0	Fos	24,27	Cholecystokinin	0,15	Fos	Cholecystokinin	314322(Tax:10116)	25298(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Cholecystokinin induces Fos expression in catecholaminergic neurons of the macaque monkey caudal medulla .
19381435	0	Fos	84,87	FosB	62,66	Fos	FosB	2353	2354	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Regulation of megakaryocytic differentiation of K562 cells by FosB , a member of the Fos family of AP-1 transcription factors .
21843570	0	Fos	27,30	Ghrelin	0,7	Fos	Ghrelin	14281(Tax:10090)	58991(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY agonists|nmod|expression agonists|nsubj|END_ENTITY	Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice .
10036969	0	Fos	62,65	Jun	78,81	Fos	Jun	2353	3725	Gene	Gene	peptides|compound|START_ENTITY peptides|nmod|dimerization dimerization|compound|END_ENTITY	Uncoiling c-Jun coiled coils : inhibitory effects of truncated Fos peptides on Jun dimerization and DNA binding in vitro .
10188588	0	Fos	25,28	Jun	63,66	Fos	Jun	314322(Tax:10116)	24516(Tax:10116)	Gene	Gene	translocation|nmod|START_ENTITY stimulated|nsubjpass|translocation stimulated|nmod|END_ENTITY	Nuclear translocation of Fos is stimulated by interaction with Jun through the leucine zipper .
11402340	0	Fos	24,27	Jun	18,21	Fos	Jun	396512(Tax:9031)	424673(Tax:9031)	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis .
1313772	0	Fos	0,3	Jun	91,94	Fos	Jun	2353	3725	Gene	Gene	repress|nsubj|START_ENTITY repress|parataxis|mediate mediate|nsubj|terminus terminus|nmod|END_ENTITY	Fos and Jun repress transcriptional activation by myogenin and MyoD : the amino terminus of Jun can mediate repression .
1594243	0	Fos	114,117	Jun	18,21	Fos	Jun	396512(Tax:9031)	424673(Tax:9031)	Gene	Gene	requirement|nmod|START_ENTITY Transformation|dep|requirement Transformation|nmod|END_ENTITY	Transformation by Jun : requirement for leucine zipper , basic region and transactivation domain and enhancement by Fos .
2111328	0	Fos	70,73	Jun	24,27	Fos	Jun	2353	3725	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|activity activity|nmod|END_ENTITY	DNA-binding activity of Jun is increased through its interaction with Fos .
2494630	0	Fos	102,105	Jun	34,37	Fos	Jun	2353	3725	Gene	Gene	protein|compound|START_ENTITY required|nmod|protein required|nsubjpass|terminus terminus|nmod|oncoprotein oncoprotein|compound|END_ENTITY	The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein .
2506451	0	Fos	2,5	Jun	29,32	Fos	Jun	2353	3725	Gene	Gene	protein|compound|START_ENTITY protein|acl|containing containing|dobj|zipper zipper|compound|END_ENTITY	A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the AP1 binding site .
2516828	0	Fos	58,61	Jun	40,43	Fos	Jun	2353	3725	Gene	Gene	requirements|dep|START_ENTITY requirements|nmod|formation formation|nmod|END_ENTITY	Different requirements for formation of Jun : Jun and Jun : Fos complexes .
2516828	0	Fos	58,61	Jun	45,48	Fos	Jun	2353	3725	Gene	Gene	requirements|dep|START_ENTITY requirements|dep|END_ENTITY	Different requirements for formation of Jun : Jun and Jun : Fos complexes .
3142691	0	Fos	68,71	Jun	39,42	Fos	Jun	14281(Tax:10090)	16476(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY activities|dep|stimulation activities|nmod|proteins proteins|compound|END_ENTITY	DNA binding activities of three murine Jun proteins : stimulation by Fos .
8140895	0	Fos	5,8	Jun	0,3	Fos	Jun	314322(Tax:10116)	24516(Tax:10116)	Gene	Gene	MyoD1|appos|START_ENTITY MyoD1|compound|END_ENTITY	Jun , Fos , MyoD1 , and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation .
2114646	0	Fos	54,57	Luteinizing_hormone-releasing_hormone	0,37	Fos	Luteinizing hormone-releasing hormone	314322(Tax:10116)	25194(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY express|dobj|protein express|nsubj|neurons neurons|amod|END_ENTITY	Luteinizing_hormone-releasing_hormone neurons express Fos protein during the proestrous surge of luteinizing hormone .
7891713	0	Fos	39,42	Maf	6,9	Fos	Maf	2353	4094	Gene	Gene	heterodimerize|nmod|START_ENTITY heterodimerize|nsubj|proteins proteins|compound|END_ENTITY	Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor .
8108109	0	Fos	62,65	Maf	0,3	nrl	Maf	4901	4094	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. .
8552399	0	Fos	73,76	Maf	28,31	Fos	Maf	14281(Tax:10090)	17132(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY modulated|nmod|proteins modulated|nsubjpass|activity activity|nmod|oncoprotein oncoprotein|compound|END_ENTITY	Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins .
8552399	0	Fos	73,76	Maf	87,90	Fos	Maf	14281(Tax:10090)	17132(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins .
8264594	0	Fos	0,3	NF-IL6	48,54	Fos	NF-IL6	2353	1051	Gene	Gene	repress|nsubj|START_ENTITY repress|nmod|END_ENTITY	Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region .
8397339	0	Fos	88,91	NFATp	32,37	Fos	NFATp	2353	4773	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. .
23714076	0	Fos	19,22	Nesfatin-1	0,10	Fos	Nesfatin-1	314322(Tax:10116)	59295(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Nesfatin-1 induces Fos expression and elicits dipsogenic responses in subfornical organ .
8938747	0	Fos	20,23	Neurotensin	0,11	Fos	Neurotensin	314322(Tax:10116)	299757(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Neurotensin induces Fos and Zif268 expression in limbic nuclei of the rat brain .
10223719	0	Fos	19,22	Noggin	0,6	Fos	Noggin	2353	9241	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Noggin upregulates Fos expression by a calcium-mediated pathway in amphibian embryos .
22293205	0	Fos	66,69	Notch2	0,6	Fos	Notch2	2353	4853	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Notch2 regulates the development of marginal zone B cells through Fos .
11930172	0	Fos	30,33	PAR-2	40,45	Fos	PAR-2	314322(Tax:10116)	116677(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|stimulation stimulation|compound|END_ENTITY	Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats .
16474935	0	Fos	29,32	PKC	8,11	Fos	PKC	2353	112476	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of PKC in regulation of Fos and TH expression after naloxone induced morphine withdrawal in the heart .
15177879	0	Fos	13,16	TFF3	0,4	Fos	TFF3	314322(Tax:10116)	25563(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus .
11463773	0	Fos	47,50	angiotensin_II	28,42	Fos	angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Inhibition of baroreflex by angiotensin_II via Fos expression in nucleus tractus solitarii of the rat .
7796121	0	Fos	0,3	angiotensin_II	59,73	Fos	angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Fos induced in brain of spontaneously hypertensive rats by angiotensin_II and co-localization with AT-1 receptors .
1978316	0	Fos	51,54	beta-endorphin	22,36	Fos	beta-endorphin	14281(Tax:10090)	18976(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Interleukin 1 induces beta-endorphin secretion via Fos and Jun in AtT-20 pituitary cells .
12902987	0	Fos	12,15	c-Fos	32,37	Fos	c-Fos	14281(Tax:10090)	14281(Tax:10090)	Gene	Gene	members|amod|START_ENTITY members|appos|END_ENTITY	Role of the Fos family members , c-Fos , Fra-1 and Fra-2 , in the regulation of cell motility .
1918021	0	Fos	46,49	endothelin-1	14,26	Fos	endothelin-1	2353	1906	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of endothelin-1 gene expression by Fos and Jun. .
11069119	0	Fos	43,46	ghrelin	27,34	Fos	ghrelin	314322(Tax:10116)	59301(Tax:10116)	Gene	Gene	proteins|amod|START_ENTITY induces|dobj|proteins induces|nsubj|administration administration|nmod|END_ENTITY	Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats .
12023064	0	Fos	41,44	ghrelin	11,18	Fos	ghrelin	14281(Tax:10090)	58991(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus .
14575873	0	Fos	45,48	ghrelin	29,36	Fos	ghrelin	314322(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|injection injection|nmod|END_ENTITY	Intraperitoneal injection of ghrelin induces Fos expression in the paraventricular nucleus of the hypothalamus in rats .
18329635	0	Fos	40,43	ghrelin	24,31	Fos	ghrelin	314322(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|injection injection|nmod|END_ENTITY	Peripheral injection of ghrelin induces Fos expression in the dorsomedial hypothalamic nucleus in rats .
8883917	0	Fos	50,53	interleukin-1	66,79	Fos	interleukin-1	14281(Tax:10090)	111343(Tax:10090)	Gene	Gene	response|compound|START_ENTITY role|nmod|response role|nmod|END_ENTITY	The role of cerebral noradrenergic systems in the Fos response to interleukin-1 .
9459544	0	Fos	98,101	luteinizing_hormone-releasing_hormone	60,97	Fos	luteinizing hormone-releasing hormone	314322(Tax:10116)	25194(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Progesterone blockade of a luteinizing hormone surge blocks luteinizing_hormone-releasing_hormone Fos activation and activation of its preoptic area afferents .
9475384	0	Fos	14,17	luteinizing_hormone-releasing_hormone	25,62	Fos	luteinizing hormone-releasing hormone	100713572	100135531(Tax:10141)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Expression of Fos within luteinizing_hormone-releasing_hormone neurons , in relation to the steroid-induced luteinizing hormone surge in guinea_pigs .
11297813	0	Fos	76,79	neurotensin	4,15	Fos	neurotensin	314322(Tax:10116)	299757(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY attenuates|dobj|expression attenuates|nsubj|SR_48692 SR_48692|compound|END_ENTITY	The neurotensin antagonist SR_48692 attenuates haloperidol-induced striatal Fos expression in the rat .
15150532	0	Fos	43,46	neurotensin	4,15	Fos	neurotensin	314322(Tax:10116)	299757(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|PD149163 PD149163|compound|END_ENTITY	The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat .
16632196	0	Fos	30,33	neurotensin	62,73	Fos	neurotensin	14281(Tax:10090)	67405(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY attenuated|nsubjpass|expression attenuated|nmod|mice mice|amod|END_ENTITY	Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice .
2512642	0	Fos	31,34	proenkephalin	14,27	Fos	proenkephalin	2353	5179	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of proenkephalin by Fos and Jun. .
20214940	0	Fos	41,44	relaxin-3	23,32	Fos	relaxin-3	314322(Tax:10116)	117579	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake .
20799851	0	Fos	0,3	tyrosine_hydroxylase	18,38	Fos	tyrosine hydroxylase	14281(Tax:10090)	21823(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Fos expression in tyrosine_hydroxylase containing hypothalamic neurons in CRH-KO mice : effect of immobilization stress .
10650129	0	Fos	0,3	urocortin	104,113	Fos	urocortin	314322(Tax:10116)	29151(Tax:10116)	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|injection injection|nmod|END_ENTITY	Fos induction in selective hypothalamic neuroendocrine and medullary nuclei by intravenous injection of urocortin and corticotropin-releasing_factor in rats .
12887419	0	Fos	58,61	urocortin	14,23	Fos	urocortin	14281(Tax:10090)	22226(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of urocortin on ingestive behaviours and brain Fos immunoreactivity in mice .
10718520	0	Fos	43,46	vasopressin	74,85	Fos	vasopressin	2353	551	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Intraventricular 2-deoxy-D-glucose induces Fos expression by hypothalamic vasopressin , but not oxytocin neurons .
8864487	0	Fos-B	93,98	c-Fos	0,5	Fos-B	c-Fos	100360880	314322(Tax:10116)	Gene	Gene	co-localization|nmod|START_ENTITY regulation|appos|co-localization expression|dep|regulation expression|amod|END_ENTITY	c-Fos expression in the rat intergeniculate leaflet : photic regulation , co-localization with Fos-B , and cellular identification .
9421421	0	Fos-regulating_kinase	40,61	Angiotensin_II	0,14	Fos-regulating kinase	Angiotensin II	79209(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates activation of Fos-regulating_kinase and c-Jun_NH2-terminal_kinase in neuronal cultures from rat brain .
8978735	0	Fos-related_antigen	24,43	FosB	78,82	Fos-related antigen	FosB	80754(Tax:10116)	100360880	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Long-term expression of Fos-related_antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum .
19381435	0	FosB	62,66	Fos	84,87	FosB	Fos	2354	2353	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Regulation of megakaryocytic differentiation of K562 cells by FosB , a member of the Fos family of AP-1 transcription factors .
8978735	0	FosB	78,82	Fos-related_antigen	24,43	FosB	Fos-related antigen	100360880	80754(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Long-term expression of Fos-related_antigen and transient expression of delta FosB associated with seizures in the rat hippocampus and striatum .
20626732	0	FosB	29,33	FosB	36,40	FosB	FosB	100360880	100360880	Gene	Gene	induction|nmod|START_ENTITY induction|parataxis|END_ENTITY	Region-specific induction of FosB / / \ FosB by voluntary alcohol intake : effects of naltrexone .
20626732	0	FosB	36,40	FosB	29,33	FosB	FosB	100360880	100360880	Gene	Gene	induction|parataxis|START_ENTITY induction|nmod|END_ENTITY	Region-specific induction of FosB / / \ FosB by voluntary alcohol intake : effects of naltrexone .
21886798	0	FosB	29,33	FosB	36,40	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Opiate sensitization induces FosB / / \ FosB expression in prefrontal cortical , striatal and amygdala brain regions .
21886798	0	FosB	36,40	FosB	29,33	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Opiate sensitization induces FosB / / \ FosB expression in prefrontal cortical , striatal and amygdala brain regions .
22792289	0	FosB	82,86	FosB	89,93	FosB	FosB	100360880	100360880	Gene	Gene	START_ENTITY|dep|levels levels|compound|END_ENTITY	Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB / / \ FosB levels in reward-related brain regions .
22792289	0	FosB	89,93	FosB	82,86	FosB	FosB	100360880	100360880	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|dep|levels	Electroacupuncture decreases excessive alcohol consumption involving reduction of FosB / / \ FosB levels in reward-related brain regions .
23185589	0	FosB	30,34	FosB	37,41	FosB	FosB	100360880	100360880	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Glucocorticoids regulation of FosB / / \ FosB expression induced by chronic opiate exposure in the brain stress system .
23185589	0	FosB	37,41	FosB	30,34	FosB	FosB	100360880	100360880	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Glucocorticoids regulation of FosB / / \ FosB expression induced by chronic opiate exposure in the brain stress system .
24355551	0	FosB	40,44	FosB	48,52	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Withdrawal induces distinct patterns of FosB / FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization .
24355551	0	FosB	48,52	FosB	40,44	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Withdrawal induces distinct patterns of FosB / FosB expression in outbred Swiss mice classified as susceptible and resistant to ethanol-induced locomotor sensitization .
25960006	0	FosB	42,46	FosB	49,53	FosB	FosB	100360880	100360880	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Impact of repeated asenapine treatment on FosB / FosB expression in neurons of the rat central nucleus of the amygdala : colocalization with corticoliberine -LRB- CRH -RRB- and effect of an unpredictable mild stress preconditioning .
25960006	0	FosB	49,53	FosB	42,46	FosB	FosB	100360880	100360880	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Impact of repeated asenapine treatment on FosB / FosB expression in neurons of the rat central nucleus of the amygdala : colocalization with corticoliberine -LRB- CRH -RRB- and effect of an unpredictable mild stress preconditioning .
26555229	0	FosB	58,62	FosB	65,69	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Repeated 6-Hz Corneal Stimulation Progressively Increases FosB / FosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the Hippocampus .
26555229	0	FosB	65,69	FosB	58,62	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Repeated 6-Hz Corneal Stimulation Progressively Increases FosB / FosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the Hippocampus .
26731014	0	FosB	86,90	FosB	93,97	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Cage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB / FosB expression .
26731014	0	FosB	93,97	FosB	86,90	FosB	FosB	14282(Tax:10090)	14282(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Cage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB / FosB expression .
14741347	0	FosB	32,36	Placental_growth_factor	0,23	FosB	Placental growth factor	2354	5228	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Placental_growth_factor induces FosB and c-Fos gene expression via Flt-1 receptors .
26949019	0	FosB	16,20	SETDB1	0,6	FosB	SETDB1	2354	9869	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	SETDB1 mediated FosB expression increases the cell proliferation rate during anticancer drug therapy .
22266344	0	FosB	26,30	c-Fos	9,14	FosB	c-Fos	100360880	314322(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY associated|nsubj|expression END_ENTITY|parataxis|associated	Regional c-Fos and FosB / / \ FosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats .
24246425	0	FosB	65,69	corticotropin-releasing_factor	15,45	FosB	corticotropin-releasing factor	100360880	81648(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of corticotropin-releasing_factor gene expression by FosB in rat hypothalamic 4B cells .
11124971	0	FosB	112,116	cyclin-dependent_kinase_5	13,38	FosB	cyclin-dependent kinase 5	14282(Tax:10090)	12568(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of cyclin-dependent_kinase_5 in the hippocampus by chronic electroconvulsive_seizures : role of -LSB- Delta -RSB- FosB .
21708480	0	Fos_Related_Activator-1	65,88	Yes-associated_protein	0,22	Fos Related Activator-1	Yes-associated protein	8061	10413	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	Yes-associated_protein promotes cell proliferation by activating Fos_Related_Activator-1 in oral_squamous_cell_carcinoma .
10655067	0	Fosl1	0,5	c-Fos	37,42	Fosl1	c-Fos	14283(Tax:10090)	14281(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation .
19713214	0	Fox-1	71,76	Fox-3	44,49	Fox-1	Fox-3	54715	146713	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Identification of neuronal_nuclei -LRB- NeuN -RRB- as Fox-3 , a new member of the Fox-1 gene family of splicing factors .
19713214	0	Fox-3	44,49	Fox-1	71,76	Fox-3	Fox-1	146713	54715	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Identification of neuronal_nuclei -LRB- NeuN -RRB- as Fox-3 , a new member of the Fox-1 gene family of splicing factors .
19713214	0	Fox-3	44,49	neuronal_nuclei	18,33	Fox-3	neuronal nuclei	146713	146713	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of neuronal_nuclei -LRB- NeuN -RRB- as Fox-3 , a new member of the Fox-1 gene family of splicing factors .
18573884	0	Fox2	33,37	hnRNP_H	0,7	Fox2	hnRNP H	23543	3187	Gene	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	hnRNP_H and hnRNP_F complex with Fox2 to silence fibroblast_growth_factor_receptor_2 exon IIIc .
21701558	0	FoxA1	90,95	Androgen_receptor	0,17	FoxA1	Androgen receptor	3169	367	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	Androgen_receptor driven transcription in molecular apocrine breast_cancer is mediated by FoxA1 .
24486549	0	FoxA1	35,40	miR-17	13,19	FoxA1	miR-17	15375(Tax:10090)	723905(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The microRNA miR-17 regulates lung FoxA1 expression during lipopolysaccharide-induced acute_lung_injury .
21982711	0	FoxA2	111,116	Akt2	65,69	FoxA2	Akt2	3170	208	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2 , FoxO1 , and SREBP1c .
21385937	0	FoxA2	52,57	PDX-1	22,27	FoxA2	PDX-1	3170	3651	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic_b-cells_dysfunction .
16522789	0	FoxA2	0,5	protein_C	36,45	FoxA2	protein C	25099(Tax:10116)	25268(Tax:10116)	Gene	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	FoxA2 involvement in suppression of protein_C , an outcome predictor in experimental sepsis .
23614500	0	FoxC2	52,57	mesenchyme_forkhead_1	29,50	FoxC2	mesenchyme forkhead 1	2303	2303	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The clinical significance of mesenchyme_forkhead_1 -LRB- FoxC2 -RRB- in gastric_carcinoma .
11451566	0	FoxH1	44,49	TGFbeta	54,61	FoxH1	TGFbeta	8928	7040	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The transcriptional role of Smads and FAST -LRB- FoxH1 -RRB- in TGFbeta and activin signalling .
17306248	0	FoxH1	0,5	flk1	27,31	FoxH1	flk1	57930(Tax:7955)	554230(Tax:7955)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish .
20233786	0	FoxL2	0,5	activin	22,29	FoxL2	activin	26927(Tax:10090)	83729	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	FoxL2 Is required for activin induction of the mouse and human follicle-stimulating_hormone_beta-subunit genes .
19106105	0	FoxL2	0,5	follistatin	38,49	FoxL2	follistatin	26927(Tax:10090)	14313(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	FoxL2 and Smad3 coordinately regulate follistatin gene transcription .
23604121	0	FoxM1	41,46	ACP5	0,4	FoxM1	ACP5	2305	54	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	ACP5 , a direct transcriptional target of FoxM1 , promotes tumor metastasis and indicates poor prognosis in hepatocellular_carcinoma .
23761826	0	FoxM1	61,66	FOXO3a	93,99	FoxM1	FOXO3a	2305	2309	Gene	Gene	repressing|dobj|START_ENTITY repressing|nmod|activation activation|nmod|END_ENTITY	Casticin induces ovarian_cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a .
26350477	0	FoxM1	61,66	Hoxa10	81,87	FoxM1	Hoxa10	14235(Tax:10090)	15395(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Control of regional decidualization in implantation : Role of FoxM1 downstream of Hoxa10 and cyclin_D3 .
25522167	0	FoxM1	12,17	OPN	0,3	FoxM1	OPN	2305	6696	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	OPN Induces FoxM1 Expression and Localization through ERK_1 / 2 , AKT , and p38 Signaling Pathway in HEC-1A Cells .
26040766	0	FoxM1	21,26	PARP3	0,5	FoxM1	PARP3	14235(Tax:10090)	235587(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance .
26444992	0	FoxM1	0,5	Sox2	106,110	FoxM1	Sox2	2305	6657	Gene	Gene	START_ENTITY|advcl|Regulating Regulating|dobj|END_ENTITY	FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2 .
18285455	0	FoxM1	14,19	cyclin_A	39,47	FoxM1	cyclin A	2305	890	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of FoxM1 during G2 requires cyclin_A / Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain .
26022336	0	FoxM1	30,35	forkhead_box_M1	13,28	FoxM1	forkhead box M1	2305	2305	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of forkhead_box_M1 -LRB- FoxM1 -RRB- by EGF through ERK signaling pathway promotes trophoblast cell invasion .
17984092	0	FoxM1	0,5	kinase-interacting_stathmin	52,79	FoxM1	kinase-interacting stathmin	2305	127933	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	FoxM1 regulates growth factor-induced expression of kinase-interacting_stathmin -LRB- KIS -RRB- to promote cell cycle progression .
19806025	0	FoxM1	39,44	p53	0,3	FoxM1	p53	2305	7157	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p53 negatively regulates expression of FoxM1 .
14686788	0	FoxM1B	64,70	Forkhead_Box_M1B	46,62	FoxM1B	Forkhead Box M1B	14235(Tax:10090)	14235(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Rapid hepatocyte nuclear translocation of the Forkhead_Box_M1B -LRB- FoxM1B -RRB- transcription factor caused a transient increase in size of regenerating transgenic hepatocytes .
20332230	0	FoxM1B	0,6	NEDD4-1	17,24	FoxM1B	NEDD4-1	2305	4734	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	FoxM1B regulates NEDD4-1 expression , leading to cellular transformation and full malignant phenotype in immortalized human astrocytes .
18974115	0	FoxM1B	0,6	vascular_endothelial_growth_factor	35,69	FoxM1B	vascular endothelial growth factor	2305	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	FoxM1B transcriptionally regulates vascular_endothelial_growth_factor expression and promotes the angiogenesis and growth of glioma cells .
26414399	0	FoxO-1	61,67	Gas6	0,4	FoxO-1	Gas6	56458(Tax:10090)	14456(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Gas6 regulates thrombin-induced expression of VCAM-1 through FoxO-1 in endothelial cells .
25065674	0	FoxO1	124,129	AMP-activated_protein_kinase	0,28	FoxO1	AMP-activated protein kinase	2308	5563	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	AMP-activated_protein_kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1 .
23684624	0	FoxO1	87,92	Adiponectin	0,11	FoxO1	Adiponectin	2308	9370	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1 .
16203862	0	FoxO1	103,108	Akt	48,51	FoxO1	Akt	2308	207	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	PGC-1alpha gene expression is down-regulated by Akt - mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle .
19767734	0	FoxO1	42,47	Cpe	32,35	FoxO1	Cpe	56458(Tax:10090)	12876(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake .
26800252	0	FoxO1	38,43	Forkhead_Box_O1	21,36	FoxO1	Forkhead Box O1	506618(Tax:9913)	506618(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Associations between Forkhead_Box_O1 -LRB- FoxO1 -RRB- Expression and Indicators of Hepatic Glucose Production in Transition Dairy Cows Supplemented with Dietary Nicotinic_Acid .
22560222	0	FoxO1	44,49	IRS2	0,4	FoxO1	IRS2	56458(Tax:10090)	384783(Tax:10090)	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action .
22291095	0	FoxO1	0,5	Ikaros	14,20	FoxO1	Ikaros	2308	10320	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination .
24551104	0	FoxO1	68,73	Insulin	0,7	FoxO1	Insulin	2308	3630	Gene	Gene	myoblasts|amod|START_ENTITY differentiation|nmod|myoblasts rescue|dobj|differentiation rescue|nsubj|END_ENTITY	Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts .
25091498	0	FoxO1	103,108	Insulin	0,7	FoxO1	Insulin	2308	3630	Gene	Gene	regulation|nmod|START_ENTITY expression|nmod|regulation drives|dobj|expression drives|nsubj|END_ENTITY	Insulin drives glucose-dependent_insulinotropic_peptide expression via glucose-dependent regulation of FoxO1 and LEF1/b-catenin .
25627686	0	FoxO1	100,105	Insulin	0,7	FoxO1	Insulin	2308	3630	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Insulin Regulates Retinol_Dehydrogenase Expression and All-trans-retinoic_Acid Biosynthesis through FoxO1 .
26929406	0	FoxO1	38,43	Insulin	186,193	FoxO1	Insulin	2308	3630	Gene	Gene	Binding|nmod|START_ENTITY Loss|nmod|Binding Forkhead|nsubj|Loss Forkhead|nmod|Genes Genes|compound|END_ENTITY	Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin Sensitive Genes .
25464856	0	FoxO1	25,30	PD-1	78,82	FoxO1	PD-1	2308	5133	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8 -LRB- + -RRB- T Cells during Chronic_Infection .
25510553	0	FoxO1	0,5	POMC	42,46	FoxO1	POMC	2308	5443	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3 .
25627686	0	FoxO1	100,105	Retinol_Dehydrogenase	18,39	FoxO1	Retinol Dehydrogenase	2308	131	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Insulin Regulates Retinol_Dehydrogenase Expression and All-trans-retinoic_Acid Biosynthesis through FoxO1 .
15766658	0	FoxO1	10,15	Skp2	0,4	FoxO1	Skp2	2308	6502	Gene	Gene	hunter|amod|START_ENTITY END_ENTITY|appos|hunter	Skp2 , the FoxO1 hunter .
22511764	0	FoxO1	0,5	Sp1	113,116	FoxO1	Sp1	56458(Tax:10090)	20683(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	FoxO1 inhibits sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene expression via transcription factors Sp1 and SREBP-1c .
26700816	0	FoxO1	15,20	TNF-a	0,5	FoxO1	TNF-a	56458(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Inhibits Inhibits|compound|END_ENTITY	TNF-a Inhibits FoxO1 by Up-regulating MiR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis .
23337584	0	FoxO1	42,47	XBP1	10,14	FoxO1	XBP1	2308	7494	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Unspliced XBP1 controls autophagy through FoxO1 .
19297333	0	FoxO1	0,5	adipose_triglyceride_lipase	33,60	FoxO1	adipose triglyceride lipase	56458(Tax:10090)	66853(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	FoxO1 controls insulin-dependent adipose_triglyceride_lipase -LRB- ATGL -RRB- expression and lipolysis in adipocytes .
24280217	0	FoxO1	88,93	claudin-5	56,65	FoxO1	claudin-5	2308	7122	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1 : role in protection from complement-mediated injury .
23347700	0	FoxO1	48,53	forkhead_box_protein_O1	23,46	FoxO1	forkhead box protein O1	2308	2308	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of forkhead_box_protein_O1 -LRB- FoxO1 -RRB- in alcohol-induced intestinal_barrier_dysfunction .
19563779	0	FoxO1	30,35	insulin	45,52	FoxO1	insulin	2308	3630	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Forkhead transcription factor FoxO1 inhibits insulin - and transforming growth factor-beta-stimulated plasminogen_activator_inhibitor-1 expression .
26206703	0	FoxO1	9,14	insulin	57,64	FoxO1	insulin	2308	3630	Gene	Gene	integrates|nsubj|START_ENTITY integrates|dobj|effects effects|nmod|END_ENTITY	Erratum : FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization .
26206703	0	FoxO1	9,14	insulin	57,64	FoxO1	insulin	2308	3630	Gene	Gene	integrates|nsubj|START_ENTITY integrates|dobj|effects effects|nmod|END_ENTITY	Erratum : FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization .
24136225	0	FoxO1	0,5	lysosomal_acid_lipase	15,36	FoxO1	lysosomal acid lipase	2308	3988	Gene	Gene	controls|amod|START_ENTITY END_ENTITY|nsubj|controls	FoxO1 controls lysosomal_acid_lipase in adipocytes : implication of lipophagy during nutrient restriction and metformin treatment .
12891709	0	FoxO1	30,35	p27Kip1	86,93	FoxO1	p27Kip1	84482(Tax:10116)	83571(Tax:10116)	Gene	Gene	transduces|nsubj|START_ENTITY transduces|nmod|END_ENTITY	Forkhead transcription factor FoxO1 transduces insulin-like growth factor 's signal to p27Kip1 in primary skeletal muscle satellite cells .
19049975	0	FoxO1	0,5	specificity_protein_1	110,131	FoxO1	specificity protein 1	2308	6667	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|blocking blocking|nmod|END_ENTITY	FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity_protein_1 .
22511764	0	FoxO1	0,5	sterol_regulatory_element-binding_protein-1c	15,59	FoxO1	sterol regulatory element-binding protein-1c	56458(Tax:10090)	20787(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	FoxO1 inhibits sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene expression via transcription factors Sp1 and SREBP-1c .
23677673	0	FoxO1	12,17	thrombospondin_1	47,63	FoxO1	thrombospondin 1	56458(Tax:10090)	21825(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Endothelial FoxO1 is an intrinsic regulator of thrombospondin_1 expression that restrains angiogenesis in ischemic muscle .
21621563	0	FoxO3	22,27	AKT_and_14-3-3	31,45	FoxO3	AKT and 14-3-3	2309	207;10971	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bimodal regulation of FoxO3 by AKT_and_14-3-3 .
15031210	0	FoxO3	48,53	GILZ	0,4	FoxO3	GILZ	56484(Tax:10090)	14605(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	GILZ , a new target for the transcription factor FoxO3 , protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis .
15705665	0	FoxO3	0,5	glucocorticoid-induced_leucine_zipper	76,113	FoxO3	glucocorticoid-induced leucine zipper	2309	1831	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|expression expression|amod|END_ENTITY	FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced_leucine_zipper expression .
21423206	0	FoxO3	23,28	p53	55,58	FoxO3	p53	2309	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|suppressor suppressor|compound|END_ENTITY	The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor .
26310353	0	FoxO3a	98,104	AKT	54,57	FoxO3a	AKT	2309	207	Gene	Gene	cisplatin|nmod|START_ENTITY cisplatin|nmod|END_ENTITY	Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a .
18458087	0	FoxO3a	77,83	Akt	0,3	FoxO3a	Akt	2309	207	Gene	Gene	inhibition|nmod|START_ENTITY cells|nmod|inhibition survival|nmod|cells regulates|dobj|survival regulates|nsubj|END_ENTITY	Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3 .
20223831	0	FoxO3a	47,53	Akt	77,80	FoxO3a	Akt	2309	207	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nmod|coordination coordination|nmod|END_ENTITY	beta1-Integrin-collagen interaction suppresses FoxO3a by the coordination of Akt and PP2A .
26373689	0	FoxO3a	109,115	Bcl-2	149,154	FoxO3a	Bcl-2	2309	596	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	AMP-activated protein kinase couples 3-bromopyruvate-induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins .
14527951	0	FoxO3a	0,6	Bim	37,40	FoxO3a	Bim	2309	10018	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast_cancer cell lines .
23257900	0	FoxO3a	55,61	Bim	48,51	FoxO3a	Bim	2309	10018	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|regulation regulation|nmod|END_ENTITY	Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells .
21965295	0	FoxO3a	28,34	NOX4	0,4	FoxO3a	NOX4	56484(Tax:10090)	50490(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	NOX4 mediates activation of FoxO3a and matrix_metalloproteinase-2 expression by urotensin-II .
16373335	0	FoxO3a	22,28	RUNX3	0,5	FoxO3a	RUNX3	56484(Tax:10090)	12399(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	RUNX3 cooperates with FoxO3a to induce apoptosis in gastric_cancer cells .
15509806	0	FoxO3a	0,6	cyclin_D2	28,37	FoxO3a	cyclin D2	2309	894	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	FoxO3a and BCR-ABL regulate cyclin_D2 transcription through a STAT5/BCL6-dependent mechanism .
19933843	0	FoxO3a	58,64	estrogen_receptor_alpha	94,117	FoxO3a	estrogen receptor alpha	2309	2099	Gene	Gene	enables|dobj|START_ENTITY enables|xcomp|have have|dobj|role role|nmod|activity activity|amod|END_ENTITY	Akt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen_receptor_alpha transcriptional activity in breast_cancer cells .
17894357	0	FoxO3a	0,6	p27Kip1	30,37	FoxO3a	p27Kip1	2309	1027	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression .
21965295	0	FoxO3a	28,34	urotensin-II	80,92	FoxO3a	urotensin-II	56484(Tax:10090)	24111(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nmod|END_ENTITY	NOX4 mediates activation of FoxO3a and matrix_metalloproteinase-2 expression by urotensin-II .
26438688	0	FoxO4	0,5	Arg1	86,90	FoxO4	Arg1	54601(Tax:10090)	11846(Tax:10090)	Gene	Gene	Response|compound|START_ENTITY Response|nmod|END_ENTITY	FoxO4 Promotes Early Inflammatory Response upon Myocardial_Infarction via Endothelial Arg1 .
18079162	0	FoxP2	11,16	FOXP2	53,58	FoxP2	FOXP2	100169841(Tax:8090)	93986	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The medaka FoxP2 , a homologue of human language gene FOXP2 , has a diverged structure and function .
27049955	0	FoxP3	87,92	4-1BB	0,5	FoxP3	4-1BB	50943	3604	Gene	Gene	Suppression|compound|START_ENTITY Production|dep|Suppression Production|nsubj|Signaling Signaling|nummod|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
19584270	0	FoxP3	66,71	Activating_transcription_factor_2	0,33	FoxP3	Activating transcription factor 2	20371(Tax:10090)	11909(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Activating_transcription_factor_2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary_tumor in the mouse .
27021296	0	FoxP3	11,16	CCR5	0,4	FoxP3	CCR5	20371(Tax:10090)	12774(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
16818678	0	FoxP3	43,48	CD127	0,5	FoxP3	CD127	50943	3575	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|compound|END_ENTITY	CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4 + T reg cells .
21413939	0	FoxP3	103,108	CD127	34,39	FoxP3	CD127	50943	3575	Gene	Gene	T|nmod|START_ENTITY T|dep|matures matures|dobj|forkhead_box_P3 forkhead_box_P3|compound|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	FoxP3	60,65	CD127	34,39	FoxP3	CD127	50943	3575	Gene	Gene	forkhead_box_P3|appos|START_ENTITY forkhead_box_P3|compound|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	FoxP3	60,65	CD127	83,88	FoxP3	CD127	50943	3575	Gene	Gene	forkhead_box_P3|appos|START_ENTITY matures|dobj|forkhead_box_P3 T|dep|matures T|nmod|FoxP3 FoxP3|amod|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
22989355	0	FoxP3	213,218	CD127	168,173	FoxP3	CD127	50943	3575	Gene	Gene	alternative|nmod|START_ENTITY END_ENTITY|nmod|alternative	Flow cytometric immunophenotyping of regulatory T cells in chronic_lymphocytic_leukemia : comparative assessment of various markers and use of novel antibody panel with CD127 as alternative to transcription factor FoxP3 .
21496498	0	FoxP3	61,66	CD154	35,40	FoxP3	CD154	20371(Tax:10090)	21947(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells induction|nmod|subset induction|nmod|END_ENTITY	Stimulation-dependent induction of CD154 on a subset of CD4 + FoxP3 + T-regulatory cells .
14597769	0	FoxP3	13,18	CD25	84,88	FoxP3	CD25	50943	3559	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|activity activity|nmod|END_ENTITY	Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4 + CD25 - T cells .
15374887	0	FoxP3	65,70	CD25	17,21	FoxP3	CD25	50943	3559	Gene	Gene	protein|amod|START_ENTITY express|dobj|protein T|acl:relcl|express END_ENTITY|dep|T	Cord blood CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function .
15837817	0	FoxP3	38,43	CD25	74,78	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	shows|dobj|START_ENTITY shows|xcomp|coexpressing coexpressing|dobj|cells cells|compound|END_ENTITY	Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes .
15939793	0	FoxP3	41,46	CD25	16,20	FoxP3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY identifies|dobj|cells identifies|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression of CD25 and CD27 identifies FoxP3 + regulatory T cells in inflamed synovia .
16259008	0	FoxP3	50,55	CD25	45,49	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Genetic control of thymic development of CD4 + CD25 + FoxP3 + regulatory T lymphocytes .
17011048	0	FoxP3	9,14	CD25	4,8	FoxP3	CD25	50943	3669	Gene	Gene	lymphocytes|amod|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + FoxP3 + T lymphocytes fail to suppress myelin_basic_protein-induced proliferation in patients with multiple_sclerosis .
17351648	0	FoxP3	97,102	CD25	91,95	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , not cyclosporine , permits thymic generation and peripheral preservation of CD4 + CD25 + FoxP3 + T cells .
17621372	0	FoxP3	39,44	CD25	34,38	FoxP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17898053	0	FoxP3	0,5	CD25	7,11	FoxP3	CD25	50943	3559	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
18025172	0	FoxP3	30,35	CD25	25,29	FoxP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2_and_4-1BB signaling .
18304876	0	FoxP3	64,69	CD25	59,63	FoxP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Islet antigen specific IL-10 + immune responses but not CD4 + CD25 + FoxP3 + cells at diagnosis predict glycemic control in type 1 diabetes .
18355177	0	FoxP3	25,30	CD25	20,24	FoxP3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Increased number of CD25 FoxP3 regulatory T cells in oral squamous_cell_carcinomas detected by chromogenic immunohistochemical double staining .
18453563	0	FoxP3	91,96	CD25	86,90	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
18469093	0	FoxP3	98,103	CD25	93,97	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
18587005	0	FoxP3	9,14	CD25	4,8	FoxP3	CD25	444998(Tax:9823)	396814(Tax:9823)	Gene	Gene	PD1|compound|START_ENTITY PD1|compound|END_ENTITY	CD4 + CD25 + FoxP3 + PD1 - regulatory T cells in acute and stable relapsing-remitting multiple_sclerosis and their modulation by therapy .
19277040	0	FoxP3	43,48	CD25	38,42	FoxP3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
19833887	0	FoxP3	50,55	CD25	60,64	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Idd9 .1 locus controls the suppressive activity of FoxP3 + CD4 + CD25 + regulatory T-cells .
20139172	0	FoxP3	89,94	CD25	84,88	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
20487258	0	FoxP3	136,141	CD25	115,119	FoxP3	CD25	50943	3559	Gene	Gene	START_ENTITY|nsubj|CD127 CD127|compound|END_ENTITY	A prospective study of T - and B-lymphocyte subpopulations , CD81 expression levels on B cells and regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- FoxP3 -LRB- + -RRB- T cells in patients with chronic_HCV_infection during pegylated interferon-alpha2a plus ribavirin treatment .
21244371	0	FoxP3	109,114	CD25	104,108	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibitor of PI3Ky ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4 + CD25 + FoxP3 + regulatory T cells .
21413939	0	FoxP3	60,65	CD25	92,96	FoxP3	CD25	50943	3559	Gene	Gene	forkhead_box_P3|appos|START_ENTITY matures|dobj|forkhead_box_P3 T|dep|matures T|nmod|FoxP3 FoxP3|compound|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21824530	0	FoxP3	93,98	CD25	87,91	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4 + CD25 + FoxP3 + T reg cells in vivo .
22211712	0	FoxP3	36,41	CD25	45,49	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The immunoregulatory role of CD4 FoxP3 CD25 regulatory T cells in lungs of mice infected with Bordetella_pertussis .
22457273	0	FoxP3	50,55	CD25	42,46	FoxP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22522779	0	FoxP3	65,70	CD25	57,61	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	grafts|dobj|START_ENTITY grafts|nmod|levels levels|nmod|END_ENTITY	Allogeneic bone marrow grafts with high levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells can lead to engraftment failure .
22716916	0	FoxP3	11,16	CD25	5,9	FoxP3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY predominant|nsubj|cells END_ENTITY|parataxis|predominant	CD4 + CD25 - FoxP3 + regulatory cells are the predominant responding regulatory T cells after human rotavirus_infection or vaccination in gnotobiotic pigs .
22760780	0	FoxP3	29,34	CD25	24,28	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral_deficiency and thrombocytopenia in a murine model of immune_thrombocytopenia .
22891289	0	FoxP3	106,111	CD25	101,105	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
23502334	0	FoxP3	28,33	CD25	22,26	FoxP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Sclareol reduces CD4 + CD25 + FoxP3 + Treg cells in a breast_cancer model in vivo .
23911408	0	FoxP3	33,38	CD25	4,8	FoxP3	CD25	50943	3559	Gene	Gene	associated|nsubjpass|START_ENTITY regs|advcl|associated regs|nsubj|T T|compound|END_ENTITY	CD4 + CD25 + T regs with acetylated FoxP3 are associated with immune suppression in human leprosy .
24214631	0	FoxP3	0,5	CD25	44,48	FoxP3	CD25	50943	3559	Gene	Gene	provides|nsubj|START_ENTITY provides|nmod|cells cells|compound|END_ENTITY	FoxP3 provides competitive fitness to CD4 CD25 T cells in leprosy patients via transcriptional regulation .
24405386	0	FoxP3	68,73	CD25	63,67	FoxP3	CD25	50943	3559	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Human adipose-derived stromal/stem cells induce functional CD4 + CD25 + FoxP3 + CD127 - regulatory T cells under low oxygen culture conditions .
24476849	0	FoxP3	27,32	CD25	22,26	FoxP3	CD25	491876(Tax:9615)	403870(Tax:9615)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Serial changes of CD4 + CD25 + FoxP3 + regulatory T cell in canine model of sepsis induced by endotoxin .
24904415	0	FoxP3	9,14	CD25	4,8	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
24904717	0	FoxP3	33,38	CD25	26,30	FoxP3	CD25	50943	3559	Gene	Gene	+|dobj|START_ENTITY +|nsubj|status status|nmod|END_ENTITY	Numerical status of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- and CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- regulatory T cells in multiple_sclerosis .
25293774	0	FoxP3	109,114	CD25	104,108	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25480168	0	FoxP3	34,39	CD25	0,4	FoxP3	CD25	50943	3559	Gene	Gene	TIL|compound|START_ENTITY subset|nmod|TIL identifies|dobj|subset identifies|nsubj|END_ENTITY	CD25 identifies a subset of CD4 FoxP3 TIL that are exhausted yet prognostically favorable in human ovarian_cancer .
25833958	0	FoxP3	111,116	CD25	106,110	FoxP3	CD25	50943	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4 + CD25 + FoxP3 + Treg .
26034548	0	FoxP3	25,30	CD25	19,23	FoxP3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Evaluation of CD4 + CD25 + FoxP3 + Regulatory T cells and FoxP3 and CTLA-4 gene Expression in Patients wwith Newly Diagnosed Tuberculosis in Northeast of Iran .
26270121	0	FoxP3	104,109	CD25	99,103	FoxP3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY +|dep|Cells +|nsubj|Role Role|nmod|Cells Cells|nmod|END_ENTITY	Interleukin-28B Plays a Therapeutic Role on Mouse U14 Cervical Cancer Cells by Down-Regulating CD4 + CD25 + FoxP3 + Regulatory T Cells In Vivo .
26333292	0	FoxP3	38,43	CD25	19,23	FoxP3	CD25	50943	3559	Gene	Gene	START_ENTITY|amod|Decrease Decrease|nmod|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
26504851	0	FoxP3	38,43	CD25	17,21	FoxP3	CD25	50943	3559	Gene	Gene	START_ENTITY|nsubj|Expansion Expansion|nmod|IL-10 IL-10|compound|END_ENTITY	The Expansion of CD25 -LRB- high -RRB- IL-10 -LRB- high -RRB- FoxP3 -LRB- high -RRB- B Regulatory Cells Is in Association with SLE_Disease Activity .
26517875	0	FoxP3	37,42	CD25	31,35	FoxP3	CD25	50943	3559	Gene	Gene	Controlled|compound|START_ENTITY Controlled|compound|END_ENTITY	Orally-Induced Intestinal CD4 + CD25 + FoxP3 + Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic_Reactions .
26829554	0	FoxP3	42,47	CD25	37,41	FoxP3	CD25	50943	3559	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
27049955	0	FoxP3	87,92	CD25	82,86	FoxP3	CD25	50943	3559	Gene	Gene	Suppression|compound|START_ENTITY Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27070362	0	FoxP3	74,79	CD25	69,73	FoxP3	CD25	50943	3559	Gene	Gene	CD127low|compound|START_ENTITY CD127low|compound|END_ENTITY	-LSB- The treatment by expanded ex vivo autologous regulatory T-cells CD4 + CD25 + FoxP3 + CD127low restores the balance of immune system in patients with remitting-relapsing multiple_sclerosis -RSB- .
20487644	0	FoxP3	47,52	CD39	56,60	FoxP3	CD39	50943	953	Gene	Gene	characteristic|nmod|START_ENTITY characteristic|dep|END_ENTITY	-LSB- Phenotypical and functional characteristic of FoxP3 -LRB- + -RRB- ; CD39 -LRB- + -RRB- ; regulatory T cells in humans -RSB- .
21047964	0	FoxP3	109,114	CD39	90,94	FoxP3	CD39	50943	953	Gene	Gene	T|compound|START_ENTITY expression|nmod|T expression|nummod|END_ENTITY	Comprehensive analysis of frequency and phenotype of T regulatory cells in HIV_infection : CD39 expression of FoxP3 + T regulatory cells correlates with progressive_disease .
22489829	0	FoxP3	22,27	CD39	14,18	FoxP3	CD39	50943	953	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Expression of CD39 on FoxP3 + T regulatory cells correlates with progression of HBV_infection .
12874208	0	FoxP3	9,14	CD4	84,87	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Scurfin|appos|START_ENTITY controls|nsubj|Scurfin controls|nmod|regulation regulation|nmod|function function|compound|END_ENTITY	Scurfin -LRB- FoxP3 -RRB- controls T-dependent immune responses in vivo through regulation of CD4 + T cell effector function .
14597769	0	FoxP3	13,18	CD4	80,83	FoxP3	CD4	50943	920	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|activity activity|nmod|CD25 CD25|compound|END_ENTITY	Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4 + CD25 - T cells .
15374887	0	FoxP3	65,70	CD4	11,14	FoxP3	CD4	50943	920	Gene	Gene	protein|amod|START_ENTITY express|dobj|protein T|acl:relcl|express CD25|dep|T CD25|compound|END_ENTITY	Cord blood CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- - derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function .
15837817	0	FoxP3	38,43	CD4	70,73	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	shows|dobj|START_ENTITY shows|xcomp|coexpressing coexpressing|dobj|cells cells|nummod|END_ENTITY	Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4 + CD25 + regulatory T cells during autoimmune diabetes .
16045746	0	FoxP3	0,5	CD4	8,11	FoxP3	CD4	50943	920	Gene	Gene	T|nsubj|START_ENTITY T|nsubj|CD25 CD25|compound|END_ENTITY	FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn 's _ disease .
16252254	0	FoxP3	125,130	CD4	121,124	FoxP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Dehydroepiandrosterone replacement in patients with Addison 's _ disease has a bimodal effect on regulatory -LRB- CD4 + CD25hi and CD4 + FoxP3 + -RRB- T cells .
16259008	0	FoxP3	50,55	CD4	41,44	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Genetic control of thymic development of CD4 + CD25 + FoxP3 + regulatory T lymphocytes .
16285010	0	FoxP3	22,27	CD4	68,71	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression controls|nsubj|regulation controls|dobj|balance balance|nmod|activation activation|compound|END_ENTITY	Dynamic regulation of FoxP3 expression controls the balance between CD4 + T cell activation and cell death .
16410445	0	FoxP3	51,56	CD4	38,41	FoxP3	CD4	50943	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|expansion expansion|nmod|CD25high CD25high|amod|naive naive|dep|END_ENTITY	In vivo peripheral expansion of naive CD4 + CD25high FoxP3 + regulatory T cells in patients with multiple_myeloma .
16841298	0	FoxP3	64,69	CD4	72,75	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|amod|START_ENTITY CD25|compound|END_ENTITY	Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells in vivo and enhances their capacity to suppress EAE .
17011048	0	FoxP3	9,14	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	lymphocytes|amod|START_ENTITY lymphocytes|compound|END_ENTITY	CD4 + CD25 + FoxP3 + T lymphocytes fail to suppress myelin_basic_protein-induced proliferation in patients with multiple_sclerosis .
17234458	0	FoxP3	13,18	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress Mycobacterium_tuberculosis immunity in patients with active disease .
17234458	4	FoxP3	635,640	CD4	622,625	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|number number|nmod|CD25 CD25|compound|END_ENTITY	Our results indicate that the number of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- Treg increases in the blood or at the site of infection in active TB patients .
17315190	0	FoxP3	4,9	CD4	0,3	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + FoxP3 + regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo .
17351648	0	FoxP3	97,102	CD4	86,89	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin , not cyclosporine , permits thymic generation and peripheral preservation of CD4 + CD25 + FoxP3 + T cells .
17412560	0	FoxP3	125,130	CD4	41,44	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	transduction|amod|START_ENTITY cells|nmod|transduction producing|dobj|cells Converting|advcl|producing Converting|dobj|END_ENTITY	Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction .
17621372	0	FoxP3	39,44	CD4	30,33	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17675459	0	FoxP3	79,84	CD4	94,97	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Cutting edge : trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4 + CD25 T cells .
17675460	0	FoxP3	69,74	CD4	76,79	FoxP3	CD4	50943	920	Gene	Gene	expand|iobj|START_ENTITY expand|dobj|cells cells|compound|END_ENTITY	Cutting edge : primary B lymphocytes preferentially expand allogeneic FoxP3 + CD4 T cells .
17675474	0	FoxP3	13,18	CD4	19,22	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Induction of FoxP3 + CD4 +25 + regulatory T cells following hemopoietic stem cell transplantation : role of bone marrow-derived facilitating cells .
17786278	0	FoxP3	91,96	CD4	39,42	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|Inhibition Inhibition|nmod|T-cells T-cells|amod|alanyl-aminopeptidase alanyl-aminopeptidase|nmod|+ +|compound|END_ENTITY	Inhibition of alanyl-aminopeptidase on CD4 + CD25 + regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute_colitis in mice .
17898053	0	FoxP3	0,5	CD4	133,136	FoxP3	CD4	50943	920	Gene	Gene	T-cell|compound|START_ENTITY macaques|nsubj|T-cell macaques|nmod|activation activation|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
18025172	0	FoxP3	30,35	CD4	21,24	FoxP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2_and_4-1BB signaling .
18171284	0	FoxP3	26,31	CD4	32,35	FoxP3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Functional suppression by FoxP3 + CD4 + CD25 -LRB- high -RRB- regulatory T cells during acute hepatitis_C_virus infection .
18453563	0	FoxP3	91,96	CD4	82,85	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
18457820	0	FoxP3	13,18	CD4	19,22	FoxP3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Induction of FoxP3 + CD4 + CD25 + regulatory T cells by a bone marrow population distinct from plasmacytoid-DC .
18469093	0	FoxP3	98,103	CD4	89,92	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Disruption of the homeostatic balance between autoaggressive -LRB- CD4 + CD40 + -RRB- and regulatory -LRB- CD4 + CD25 + FoxP3 + -RRB- T cells promotes diabetes .
18587005	0	FoxP3	9,14	CD4	0,3	FoxP3	CD4	444998(Tax:9823)	404704(Tax:9823)	Gene	Gene	PD1|compound|START_ENTITY PD1|compound|END_ENTITY	CD4 + CD25 + FoxP3 + PD1 - regulatory T cells in acute and stable relapsing-remitting multiple_sclerosis and their modulation by therapy .
18641318	0	FoxP3	68,73	CD4	63,66	FoxP3	CD4	50943	920	Gene	Gene	homeostasis|compound|START_ENTITY homeostasis|compound|END_ENTITY	CTLA4 expression is an indicator and regulator of steady-state CD4 + FoxP3 + T cell homeostasis .
19111574	0	FoxP3	12,17	CD4	18,21	FoxP3	CD4	50943	920	Gene	Gene	role|nmod|START_ENTITY +|nsubj|role +|dobj|Tregs Tregs|compound|END_ENTITY	The role of FoxP3 + CD4 + CD25hi Tregs in the pathogenesis of myasthenia_gravis .
19133978	0	FoxP3	13,18	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19133978	0	FoxP3	13,18	CD4	68,71	FoxP3	CD4	50943	920	Gene	Gene	increased|dep|START_ENTITY increased|dobj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19193737	0	FoxP3	68,73	CD4	53,56	FoxP3	CD4	50943	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	End-stage_renal_failure and regulatory activities of CD4 + CD25bright + FoxP3 + T-cells .
19249569	0	FoxP3	51,56	CD4	37,40	FoxP3	CD4	101018460	100303658(Tax:9555)	Gene	Gene	T|nsubj|START_ENTITY enrichment|acl:relcl|T enrichment|nmod|CD25 CD25|compound|END_ENTITY	Rapamycin promotes the enrichment of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- FoxP3 -LRB- + -RRB- T regulatory cells from na ve CD4 -LRB- + -RRB- T cells of baboon that suppress antiporcine xenogenic response in vitro .
19249569	0	FoxP3	51,56	CD4	91,94	FoxP3	CD4	101018460	100303658(Tax:9555)	Gene	Gene	T|nsubj|START_ENTITY T|advcl|na na|dobj|T T|compound|END_ENTITY	Rapamycin promotes the enrichment of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- FoxP3 -LRB- + -RRB- T regulatory cells from na ve CD4 -LRB- + -RRB- T cells of baboon that suppress antiporcine xenogenic response in vitro .
19277040	0	FoxP3	43,48	CD4	34,37	FoxP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
19363449	0	FoxP3	33,38	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	expressing|dobj|START_ENTITY +|acl|expressing +|compound|END_ENTITY	CD4 + and CD8 + T cells expressing FoxP3 in HIV-infected patients are phenotypically distinct and influenced by disease severity and antiretroviral therapy .
19453998	0	FoxP3	53,58	CD4	44,47	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Monotherapy rapamycin allows an increase of CD4 CD25 FoxP3 T cells in renal recipients .
19464196	0	FoxP3	89,94	CD4	61,64	FoxP3	CD4	50943	920	Gene	Gene	factor|amod|START_ENTITY expressing|dobj|factor delineation|acl|expressing delineation|nmod|cells cells|compound|END_ENTITY	Functional delineation and differentiation dynamics of human CD4 + T cells expressing the FoxP3 transcription factor .
19557878	0	FoxP3	71,76	CD4	58,61	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY favors|nmod|cells favors|dobj|induction induction|nmod|CD25 CD25|compound|END_ENTITY	Low-dose of tacrolimus favors the induction of functional CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells in solid-organ transplantation .
19604307	0	FoxP3	48,53	CD4	43,46	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nummod|+ +|compound|END_ENTITY	Depletion of gammadelta + _ T cells increases CD4 + FoxP3 -LRB- T regulatory -RRB- cell response in coxsackievirus B3-induced myocarditis .
19684083	0	FoxP3	39,44	CD4	45,48	FoxP3	CD4	50943	920	Gene	Gene	expansion|nmod|START_ENTITY +|nsubj|expansion +|dobj|cells cells|nummod|END_ENTITY	Direct expansion of human allospecific FoxP3 + CD4 + regulatory T cells with allogeneic B cells for therapeutic application .
19833887	0	FoxP3	50,55	CD4	56,59	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Idd9 .1 locus controls the suppressive activity of FoxP3 + CD4 + CD25 + regulatory T-cells .
19845758	0	FoxP3	85,90	CD4	111,114	FoxP3	CD4	50943	920	Gene	Gene	expression|amod|START_ENTITY upregulation|nmod|expression induced|dobj|upregulation induced|nmod|CD25high CD25high|compound|END_ENTITY	The NF-kappaB signalling pathway is involved in the LPS/IL -2 - induced upregulation of FoxP3 expression in human CD4 + CD25high regulatory T cells .
19855964	0	FoxP3	26,31	CD4	35,38	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Homeostasis of peripheral FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells in patients with early and late stage breast_cancer .
20070404	0	FoxP3	26,31	CD4	13,16	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Expansion Expansion|nmod|CD25 CD25|compound|END_ENTITY	Expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells in hepatitis_C virus-related chronic_hepatitis , cirrhosis and hepatocellular_carcinoma .
20096404	0	FoxP3	38,43	CD4	20,23	FoxP3	CD4	50943	920	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	Regulatory T cells -LRB- CD4 -LRB- + -RRB- CD25 -LRB- bright -RRB- FoxP3 -LRB- + -RRB- -RRB- expansion in systemic_sclerosis correlates with disease activity and severity .
20139172	0	FoxP3	89,94	CD4	80,83	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
20173391	0	FoxP3	31,36	CD4	27,30	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20525892	0	FoxP3	110,115	CD4	106,109	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	FoxP3	110,115	CD4	56,59	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|resistance resistance|nmod|FoxP3 FoxP3|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	FoxP3	60,65	CD4	106,109	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	resistance|nmod|START_ENTITY induces|dobj|resistance induces|nmod|cells cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20628341	0	FoxP3	28,33	CD4	24,27	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Decreased percentage of CD4 + FoxP3 + cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis_obliterans_syndrome .
21030463	0	FoxP3	0,5	CD4	7,10	FoxP3	CD4	50943	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	FoxP3 + CD4 + T cells in systemic autoimmune_diseases : the delicate balance between true regulatory T cells and effector Th-17 cells .
21244371	0	FoxP3	109,114	CD4	100,103	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inhibitor of PI3Ky ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4 + CD25 + FoxP3 + regulatory T cells .
21251981	0	FoxP3	66,71	CD4	47,50	FoxP3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY induce|nmod|cells induce|dobj|CD25 CD25|compound|END_ENTITY	Soluble donor-like MHC class I proteins induce CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD8 -LRB- - -RRB- FoxP3 -LRB- + -RRB- cells with potential to ameliorate graft chronic injury .
21437674	0	FoxP3	98,103	CD4	94,97	FoxP3	CD4	50943	920	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation , increases CD4 + FoxP3 + Treg cell population and prevents signs of experimental_autoimmune_encephalomyelitis in mice .
21463298	0	FoxP3	10,15	CD4	5,8	FoxP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Both CD4 + FoxP3 + and CD4 + FoxP3 - T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro .
21463298	0	FoxP3	26,31	CD4	5,8	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Both CD4 + FoxP3 + and CD4 + FoxP3 - T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro .
21469091	0	FoxP3	76,81	CD4	83,86	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3 + CD4 + T cells with limited suppressor activity .
21496498	0	FoxP3	61,66	CD4	56,59	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Stimulation-dependent induction of CD154 on a subset of CD4 + FoxP3 + T-regulatory cells .
21631498	0	FoxP3	106,111	CD4	99,102	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|consequences consequences|nmod|expression expression|nmod|END_ENTITY	The phenotypic and functional consequences of tumour_necrosis_factor_receptor_type_2 expression on CD4 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21635972	0	FoxP3	59,64	CD4	55,58	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Resolving the identity myth : key markers of functional CD4 + FoxP3 + regulatory T cells .
21700344	0	FoxP3	29,34	CD4	0,3	FoxP3	CD4	100052226(Tax:9796)	100052502(Tax:9796)	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|compound|END_ENTITY	CD4 + CD25 + T cells expressing FoxP3 in Icelandic horses affected with insect_bite_hypersensitivity .
21824530	0	FoxP3	93,98	CD4	82,85	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antitumor and immunomodulatory properties of artemether and its ability to reduce CD4 + CD25 + FoxP3 + T reg cells in vivo .
22169715	0	FoxP3	15,20	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T regulatory cells in subjects responsive or unresponsive to hepatitis_B vaccination .
22373353	0	FoxP3	15,20	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress cytotoxicity of CD8 -LRB- + -RRB- effector T cells : implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level .
22457273	0	FoxP3	50,55	CD4	118,121	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nmod|patients patients|nmod|repopulation repopulation|compound|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22457273	0	FoxP3	50,55	CD4	36,39	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|CD25 CD25|compound|END_ENTITY	Severe immune dysregulation affects CD4 CD25 -LRB- hi -RRB- FoxP3 regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy .
22510013	0	FoxP3	48,53	CD4	34,37	FoxP3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The frequency of peripheral blood CD4 + CD25high FoxP3 + and CD4 + CD25 - FoxP3 + regulatory T cells in normal pregnancy and pre-eclampsia .
22510013	0	FoxP3	70,75	CD4	34,37	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY frequency|dep|cells frequency|nmod|+ +|compound|END_ENTITY	The frequency of peripheral blood CD4 + CD25high FoxP3 + and CD4 + CD25 - FoxP3 + regulatory T cells in normal pregnancy and pre-eclampsia .
22522779	0	FoxP3	65,70	CD4	50,53	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	grafts|dobj|START_ENTITY grafts|nmod|levels levels|nmod|CD25 CD25|compound|END_ENTITY	Allogeneic bone marrow grafts with high levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells can lead to engraftment failure .
22628434	0	FoxP3	30,35	CD4	26,29	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Low levels of circulating CD4 + FoxP3 + T cells are associated with an increased risk for development of myocardial_infarction but not for stroke .
22647666	0	FoxP3	48,53	CD4	54,57	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	HTLV-1 modulates the frequency and phenotype of FoxP3 + CD4 + T cells in virus-infected individuals .
22716916	0	FoxP3	11,16	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY predominant|nsubj|cells CD25|parataxis|predominant CD25|compound|END_ENTITY	CD4 + CD25 - FoxP3 + regulatory cells are the predominant responding regulatory T cells after human rotavirus_infection or vaccination in gnotobiotic pigs .
22760780	0	FoxP3	29,34	CD4	20,23	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Thymic retention of CD4 + CD25 + FoxP3 + T regulatory cells is associated with their peripheral_deficiency and thrombocytopenia in a murine model of immune_thrombocytopenia .
22793523	0	FoxP3	24,29	CD4	14,17	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nummod|+ +|compound|END_ENTITY	The decreased CD4 + CD25 + FoxP3 + T cells in nonstimulated allergic_rhinitis patients sensitized to house dust mites .
22870329	0	FoxP3	83,88	CD4	60,63	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|conversion conversion|nmod|cells cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22870329	0	FoxP3	83,88	CD4	78,81	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22871805	0	FoxP3	0,5	CD4	20,23	FoxP3	CD4	50943	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	FoxP3 regulatory CD4 T cells control the generation of functional CD8 memory .
22891289	0	FoxP3	106,111	CD4	124,127	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nmod|CD25-FoxP3 CD25-FoxP3|nummod|+ +|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
22891289	0	FoxP3	106,111	CD4	97,100	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-b-induced differentiation of CD4 + CD25 + FoxP3 + Tregs from CD4 + CD25-FoxP3 - T cells .
23019895	0	FoxP3	62,67	CD4	49,52	FoxP3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Regulation effect of scorpio and scolopendra on CD4 + CD25 + FoxP3 + Treg cell in peripheral blood from rats with collagen-induced_arthritis -LRB- CIA -RRB- -RSB- .
23124877	0	FoxP3	25,30	CD4	20,23	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Flt3_ligand expands CD4 + FoxP3 + regulatory T cells in human subjects .
23241113	0	FoxP3	138,143	CD4	39,42	FoxP3	CD4	50943	920	Gene	Gene	expressions|compound|START_ENTITY relevance|nmod|expressions pathogenesis|dobj|relevance pathogenesis|dep|cells cells|dep|CD25highCD127low CD25highCD127low|compound|END_ENTITY	Phenotypic characterization of ex vivo CD4 + CD25highCD127low immune regulatory T cells in allergic_asthma : pathogenesis relevance of their FoxP3 , GITR , CTLA-4 and FAS expressions .
23365580	0	FoxP3	46,51	CD4	11,14	FoxP3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	Cells|appos|START_ENTITY Changes|dep|Cells Changes|nmod|CD25 CD25|compound|END_ENTITY	Changes of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Regulatory T Cells , FoxP3 in Adjuvant_Arthritis Rats with Damage of Pulmonary Function and Effects of Tripterygium_Glycosides Tablet .
23499512	0	FoxP3	72,77	CD4	56,59	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|amod|Influence Influence|nmod|agents agents|nmod|CD25 CD25|compound|END_ENTITY	Influence of pharmacological immunomodulatory agents on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T regulatory cells in humans .
23502334	0	FoxP3	28,33	CD4	17,20	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Sclareol reduces CD4 + CD25 + FoxP3 + Treg cells in a breast_cancer model in vivo .
23628056	0	FoxP3	12,17	CD4	19,22	FoxP3	CD4	50943	920	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|CD25 CD25|compound|END_ENTITY	-LSB- Changes of FoxP3 , CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , TLR2 and TLR9 in children with infectious_mononucleosis -RSB- .
23700559	0	FoxP3	43,48	CD4	28,31	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Evaluation Evaluation|nmod|Number Number|nmod|CD25 CD25|compound|END_ENTITY	Evaluation of The Number of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- Treg Cells in Normal Mice Exposed to AFB1 and Treated with Aged Garlic Extract .
23769052	0	FoxP3	61,66	CD4	46,49	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|Differences Differences|nmod|induction induction|nmod|CD25 CD25|compound|END_ENTITY	Differences in the induction of induced human CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T-regulatory cells and CD3 -LRB- + -RRB- CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- T-suppressor cells subset phenotypes in vitro : comparison of phorbol_12-myristate_13-acetate / ionomycin and phytohemagglutinin stimulation .
23911408	0	FoxP3	33,38	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	associated|nsubjpass|START_ENTITY regs|advcl|associated regs|nsubj|T T|compound|END_ENTITY	CD4 + CD25 + T regs with acetylated FoxP3 are associated with immune suppression in human leprosy .
23968502	0	FoxP3	63,68	CD4	32,35	FoxP3	CD4	50943	920	Gene	Gene	3|appos|START_ENTITY T|nsubj|3 protein|acl:relcl|T forkhead|dobj|protein forkhead|nsubj|Imbalance Imbalance|nmod|types types|nmod|END_ENTITY	Imbalance of different types of CD4 -LRB- + -RRB- forkhead box protein 3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells in patients with new-onset systemic_lupus_erythematosus .
24127572	0	FoxP3	49,54	CD4	55,58	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Anti-CCR4 mAb selectively depletes effector-type FoxP3 + CD4 + regulatory T cells , evoking antitumor immune responses in humans .
24214631	0	FoxP3	0,5	CD4	38,41	FoxP3	CD4	50943	920	Gene	Gene	provides|nsubj|START_ENTITY provides|nmod|cells cells|nummod|END_ENTITY	FoxP3 provides competitive fitness to CD4 CD25 T cells in leprosy patients via transcriptional regulation .
24354800	0	FoxP3	52,57	CD4	33,36	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|ratio ratio|nmod|CD25 CD25|compound|END_ENTITY	Critical stoichiometric ratio of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells and CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- responder T cells influence immunosuppression in patients with B-cell_acute_lymphoblastic_leukaemia .
24372806	0	FoxP3	57,62	CD4	39,42	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|B B|nmod|CD25 CD25|compound|END_ENTITY	Effect of narrow band-ultraviolet B on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T-lymphocytes in the peripheral blood of vitiligo patients .
24396417	0	FoxP3	13,18	CD4	0,3	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells and cytokines interact with estradiol in cases of missed_abortion .
24405386	0	FoxP3	68,73	CD4	59,62	FoxP3	CD4	50943	920	Gene	Gene	CD127|compound|START_ENTITY CD127|compound|END_ENTITY	Human adipose-derived stromal/stem cells induce functional CD4 + CD25 + FoxP3 + CD127 - regulatory T cells under low oxygen culture conditions .
24476849	0	FoxP3	27,32	CD4	18,21	FoxP3	CD4	491876(Tax:9615)	403931(Tax:9615)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Serial changes of CD4 + CD25 + FoxP3 + regulatory T cell in canine model of sepsis induced by endotoxin .
24498995	0	FoxP3	106,111	CD4	102,105	FoxP3	CD4	50943	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	IL-10 promoter polymorphisms influence susceptibility to aGvHD and are associated with proportions of CD4 + FoxP3 + lymphocytes in blood after hematopoietic stem cell transplantation .
24766907	0	FoxP3	88,93	CD4	83,86	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4 + FoxP3 + regulatory T cells .
24872025	0	FoxP3	146,151	CD4	142,145	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nummod|+ +|compound|END_ENTITY	Episomal expression of truncated listeriolysin_O in LmddA-LLO-E7 vaccine enhances antitumor efficacy by preferentially inducing expansions of CD4 + FoxP3 - and CD8 + T cells .
24904415	0	FoxP3	9,14	CD4	0,3	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
24904717	0	FoxP3	33,38	CD4	20,23	FoxP3	CD4	50943	920	Gene	Gene	+|dobj|START_ENTITY +|nsubj|status status|nmod|CD25 CD25|compound|END_ENTITY	Numerical status of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- and CD8 -LRB- + -RRB- CD28 -LRB- - -RRB- regulatory T cells in multiple_sclerosis .
25293774	0	FoxP3	109,114	CD4	0,3	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|amod|START_ENTITY expansion|nmod|+ GVHD|nmod|expansion GVHD|dep|invariant invariant|nsubj|+ +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25293774	0	FoxP3	109,114	CD4	100,103	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	CD4 + invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4 + CD25 + FoxP3 + regulatory T cells .
25480168	0	FoxP3	34,39	CD4	28,31	FoxP3	CD4	50943	920	Gene	Gene	TIL|compound|START_ENTITY TIL|compound|END_ENTITY	CD25 identifies a subset of CD4 FoxP3 TIL that are exhausted yet prognostically favorable in human ovarian_cancer .
25499021	0	FoxP3	187,192	CD4	205,208	FoxP3	CD4	50943	920	Gene	Gene	reduce|iobj|START_ENTITY reduce|dobj|ratio ratio|nmod|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
25631159	0	FoxP3	65,70	CD4	50,53	FoxP3	CD4	50943	920	Gene	Gene	grafts|dobj|START_ENTITY grafts|nmod|levels levels|nmod|CD25 CD25|compound|END_ENTITY	Allogeneic bone marrow grafts with high levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells can lead to engraftment failure .
25717504	1	FoxP3	78,83	CD4	74,77	FoxP3	CD4	50943	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	The peripheral pool of gut-homing CD4 + beta7 + T-cells and regulatory CD4 + FoxP3 + T-cells is maintained in Crohn 's _ disease patients with small_bowel_inflammation .
25833958	0	FoxP3	111,116	CD4	102,105	FoxP3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Synergy between rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell-dependent induction of CD4 + CD25 + FoxP3 + Treg .
25856405	0	FoxP3	34,39	CD4	29,32	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	The Critical Role of Induced CD4 + FoxP3 + Regulatory Cells in Suppression of Interleukin-17 Production and Attenuation of Mouse Orthotopic Lung Allograft Rejection .
25890330	0	FoxP3	57,62	CD4	42,45	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expansion|dep|START_ENTITY expansion|nmod|CD25 CD25|compound|END_ENTITY	Jagged-1 is required for the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells .
26034548	0	FoxP3	25,30	CD4	14,17	FoxP3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Evaluation of CD4 + CD25 + FoxP3 + Regulatory T cells and FoxP3 and CTLA-4 gene Expression in Patients wwith Newly Diagnosed Tuberculosis in Northeast of Iran .
26124848	0	FoxP3	28,33	CD4	15,18	FoxP3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY Association|nmod|cells Association|nmod|CD25 CD25|compound|END_ENTITY	Association of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with natural course of childhood chronic immune_thrombocytopenic_purpura .
26182204	0	FoxP3	11,16	CD4	29,32	FoxP3	CD4	50943	920	Gene	Gene	Decline|nmod|START_ENTITY +|nsubj|Decline +|dobj|Cells Cells|compound|END_ENTITY	Decline of FoxP3 + Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria .
26219909	0	FoxP3	30,35	CD4	12,15	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	Circulating CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T-regulatory cells in patients with atopic_dermatitis after narrowband-ultraviolet B phototherapy .
26219909	0	FoxP3	30,35	CD4	12,15	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	Circulating CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- T-regulatory cells in patients with atopic_dermatitis after narrowband-ultraviolet B phototherapy .
26270121	0	FoxP3	104,109	CD4	95,98	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY +|dep|Cells +|nsubj|Role Role|nmod|Cells Cells|nmod|CD25 CD25|compound|END_ENTITY	Interleukin-28B Plays a Therapeutic Role on Mouse U14 Cervical Cancer Cells by Down-Regulating CD4 + CD25 + FoxP3 + Regulatory T Cells In Vivo .
26333292	0	FoxP3	38,43	CD4	12,15	FoxP3	CD4	50943	920	Gene	Gene	START_ENTITY|amod|Decrease Decrease|nmod|CD25 CD25|compound|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low -RRB- FoxP3 -LRB- + -RRB- regulatory T cells with impaired suppressive function in untreated ulcerative_colitis patients .
26429981	0	FoxP3	18,23	CD4	25,28	FoxP3	CD4	50943	920	Gene	Gene	Study|nmod|START_ENTITY +|nsubj|Study +|dobj|Depletion Depletion|compound|END_ENTITY	Phase Ia Study of FoxP3 + CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody , KW-0761 , in Cancer Patients .
26517875	0	FoxP3	37,42	CD4	26,29	FoxP3	CD4	50943	920	Gene	Gene	Controlled|compound|START_ENTITY Controlled|compound|END_ENTITY	Orally-Induced Intestinal CD4 + CD25 + FoxP3 + Treg Controlled Undesired Responses towards Oral Antigens and Effectively Dampened Food Allergic_Reactions .
26829554	0	FoxP3	42,47	CD4	33,36	FoxP3	CD4	50943	920	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
27021296	0	FoxP3	11,16	CD4	27,30	FoxP3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
27049955	0	FoxP3	87,92	CD4	78,81	FoxP3	CD4	50943	920	Gene	Gene	Suppression|compound|START_ENTITY Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27070362	0	FoxP3	74,79	CD4	65,68	FoxP3	CD4	50943	920	Gene	Gene	CD127low|compound|START_ENTITY CD127low|compound|END_ENTITY	-LSB- The treatment by expanded ex vivo autologous regulatory T-cells CD4 + CD25 + FoxP3 + CD127low restores the balance of immune system in patients with remitting-relapsing multiple_sclerosis -RSB- .
17617596	0	FoxP3	43,48	CD8	106,109	FoxP3	CD8	50943	925	Gene	Gene	expansion|nmod|START_ENTITY +|nsubj|expansion +|dobj|cells cells|compound|END_ENTITY	Parallel expansion of human virus-specific FoxP3 - effector memory and de novo-generated FoxP3 + regulatory CD8 + T cells upon antigen recognition in vitro .
17898053	0	FoxP3	0,5	CD8	13,16	FoxP3	CD8	50943	925	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	FoxP3 + CD25 + CD8 + T-cell induction during primary simian_immunodeficiency_virus_infection in cynomolgus macaques correlates with low CD4 + T-cell activation and high viral load .
19133978	0	FoxP3	13,18	CD8	74,77	FoxP3	CD8	50943	925	Gene	Gene	increased|dep|START_ENTITY increased|nsubjpass|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells are increased whilst CD3 -LRB- + -RRB- CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- alphabetaTCR -LRB- + -RRB- Double Negative T cells are decreased in the peripheral blood of patients with multiple_myeloma which correlates with disease burden .
19321758	0	FoxP3	69,74	CD8	87,90	FoxP3	CD8	50943	925	Gene	Gene	expansion|nmod|START_ENTITY Determinants|nmod|expansion +|nsubj|Determinants +|dobj|cells cells|compound|END_ENTITY	Determinants of in vitro expansion of different human virus-specific FoxP3 + regulatory CD8 + T cells in chronic_hepatitis_C_virus_infection .
21652515	0	FoxP3	9,14	CD8	91,94	FoxP3	CD8	50943	925	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|enhance enhance|dobj|activity activity|nmod|CD28-CTL CD28-CTL|compound|END_ENTITY	CD4 + CD25 + FoxP3 + regulatory T cells enhance the allogeneic activity of endothelial-specific CD8 + / CD28-CTL .
22092408	0	FoxP3	78,83	CD8	70,73	FoxP3	CD8	50943	925	Gene	Gene	cells|amod|START_ENTITY +|nmod|cells +|compound|END_ENTITY	In breast_cancer , a high ratio of tumour-infiltrating intraepithelial CD8 + to FoxP3 + cells is characteristic for the medullary subtype .
22373353	0	FoxP3	15,20	CD8	68,71	FoxP3	CD8	50943	925	Gene	Gene	START_ENTITY|dobj|cells cells|dep|suppress suppress|dobj|cytotoxicity cytotoxicity|nmod|cells cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells suppress cytotoxicity of CD8 -LRB- + -RRB- effector T cells : implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level .
22871805	0	FoxP3	0,5	CD8	69,72	FoxP3	CD8	50943	925	Gene	Gene	cells|nummod|START_ENTITY control|nsubj|cells control|dobj|generation generation|nmod|memory memory|amod|functional functional|dep|END_ENTITY	FoxP3 regulatory CD4 T cells control the generation of functional CD8 memory .
22879926	0	FoxP3	21,26	CD8	62,65	FoxP3	CD8	50943	925	Gene	Gene	impact|nmod|START_ENTITY +|nsubj|impact +|nmod|density density|compound|END_ENTITY	Prognostic impact of FoxP3 + regulatory T cells in relation to CD8 + T lymphocyte density in human colon_carcinomas .
24980778	0	FoxP3	12,17	CD8	8,11	FoxP3	CD8	50943	925	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Induced CD8 + FoxP3 + Treg Cells in Rheumatoid_Arthritis Are Modulated by p38 Phosphorylation and Monocytes Expressing Membrane Tumor_Necrosis_Factor_a and CD86 .
16517699	0	FoxP3	65,70	CTLA-4	18,24	FoxP3	CTLA-4	20371(Tax:10090)	12477(Tax:10090)	Gene	Gene	induce|dobj|START_ENTITY requires|xcomp|induce requires|dobj|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
18523152	0	FoxP3	23,28	CTLA4	0,5	FoxP3	CTLA4	50943	1493	Gene	Gene	regulatory|amod|START_ENTITY expands|dobj|regulatory expands|nsubj|blockade blockade|compound|END_ENTITY	CTLA4 blockade expands FoxP3 + regulatory and activated effector CD4 + T cells in a dose-dependent fashion .
18641318	0	FoxP3	68,73	CTLA4	0,5	FoxP3	CTLA4	50943	1493	Gene	Gene	homeostasis|compound|START_ENTITY indicator|nmod|homeostasis indicator|nsubj|expression expression|compound|END_ENTITY	CTLA4 expression is an indicator and regulator of steady-state CD4 + FoxP3 + T cell homeostasis .
21937704	0	FoxP3	35,40	CTLA4	48,53	FoxP3	CTLA4	50943	1493	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD147 -LRB- Basigin/Emmprin -RRB- identifies FoxP3 + CD45RO + CTLA4 + - activated human regulatory T cells .
20525892	0	FoxP3	110,115	FoxP3	60,65	FoxP3	FoxP3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|dobj|resistance resistance|nmod|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	FoxP3	60,65	FoxP3	110,115	FoxP3	FoxP3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	resistance|nmod|START_ENTITY induces|dobj|resistance induces|nmod|cells cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
21463298	0	FoxP3	10,15	FoxP3	26,31	FoxP3	FoxP3	50943	50943	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Both CD4 + FoxP3 + and CD4 + FoxP3 - T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro .
21463298	0	FoxP3	26,31	FoxP3	10,15	FoxP3	FoxP3	50943	50943	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Both CD4 + FoxP3 + and CD4 + FoxP3 - T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro .
22510013	0	FoxP3	48,53	FoxP3	70,75	FoxP3	FoxP3	50943	50943	Gene	Gene	+|compound|START_ENTITY frequency|nmod|+ frequency|dep|cells cells|amod|END_ENTITY	The frequency of peripheral blood CD4 + CD25high FoxP3 + and CD4 + CD25 - FoxP3 + regulatory T cells in normal pregnancy and pre-eclampsia .
22510013	0	FoxP3	70,75	FoxP3	48,53	FoxP3	FoxP3	50943	50943	Gene	Gene	cells|amod|START_ENTITY frequency|dep|cells frequency|nmod|+ +|compound|END_ENTITY	The frequency of peripheral blood CD4 + CD25high FoxP3 + and CD4 + CD25 - FoxP3 + regulatory T cells in normal pregnancy and pre-eclampsia .
19132983	0	FoxP3	7,12	GAD65	70,75	FoxP3	GAD65	50943	2572	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Higher FoxP3 mRNA expression in peripheral blood mononuclear cells of GAD65 or IA-2 autoantibody-positive compared with autoantibody-negative persons .
20139172	0	FoxP3	89,94	GITR	0,4	FoxP3	GITR	20371(Tax:10090)	21936(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells enhances|dobj|proliferation enhances|nsubj|engagement engagement|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
21570917	0	FoxP3	26,31	Helios	87,93	FoxP3	Helios	50943	22807	Gene	Gene	+|amod|START_ENTITY subpopulation|nmod|+ T|nsubj|subpopulation T|dobj|cells cells|nmod|END_ENTITY	Expanded subpopulation of FoxP3 + T regulatory cells in renal_cell_carcinoma co-express Helios , indicating they could be derived from natural but not induced Tregs .
22827571	0	FoxP3	21,26	Helios	0,6	FoxP3	Helios	50943	22807	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Helios expression in FoxP3 -LRB- + -RRB- T regulatory cells .
23925905	0	FoxP3	18,23	Helios	24,30	FoxP3	Helios	50943	22807	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The percentage of FoxP3 + Helios + Treg cells correlates positively with disease activity in systemic_lupus_erythematosus .
25733061	0	FoxP3	55,60	Helios	0,6	FoxP3	Helios	20371(Tax:10090)	22779(Tax:10090)	Gene	Gene	Enhances|nmod|START_ENTITY Enhances|nsubj|END_ENTITY	Helios Enhances Treg Cell Function in Cooperation With FoxP3 .
26076982	0	FoxP3	52,57	Helios	28,34	FoxP3	Helios	50943	22807	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	IL-1R1 is expressed on both Helios -LRB- + -RRB- and Helios -LRB- - -RRB- FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells in the rheumatic_joint .
22870329	0	FoxP3	83,88	IFN-y	126,131	FoxP3	IFN-y	50943	3458	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
26504851	0	FoxP3	38,43	IL-10	27,32	FoxP3	IL-10	50943	3586	Gene	Gene	START_ENTITY|nsubj|Expansion Expansion|nmod|END_ENTITY	The Expansion of CD25 -LRB- high -RRB- IL-10 -LRB- high -RRB- FoxP3 -LRB- high -RRB- B Regulatory Cells Is in Association with SLE_Disease Activity .
26829554	0	FoxP3	42,47	IL-10	13,18	FoxP3	IL-10	50943	3586	Gene	Gene	Correlates|compound|START_ENTITY Induction|nmod|Correlates Induction|nmod|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
18713984	0	FoxP3	13,18	IL-17	46,51	FoxP3	IL-17	20371(Tax:10090)	16171(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY become|nsubj|cells become|xcomp|effectors effectors|amod|+ +|amod|END_ENTITY	Reprogrammed FoxP3 + T regulatory cells become IL-17 + antigen-specific autoimmune effectors in vitro and in vivo .
23776439	0	FoxP3	32,37	IL-17	111,116	FoxP3	IL-17	50943	3605	Gene	Gene	levels|nmod|START_ENTITY T|nsubj|levels T|ccomp|contribute contribute|nmod|secretion secretion|nmod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
19635906	0	FoxP3	28,33	IL-2	96,100	FoxP3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	persistence|compound|START_ENTITY persistence|nmod|production production|nmod|END_ENTITY	CD44 costimulation promotes FoxP3 + regulatory T cell persistence and function via production of IL-2 , IL-10 , and TGF-beta .
21469091	0	FoxP3	76,81	IL-2	8,12	FoxP3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY increase|nmod|cells leads|nmod|increase leads|nsubj|expression expression|compound|END_ENTITY	Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3 + CD4 + T cells with limited suppressor activity .
24633065	0	FoxP3	0,5	IL-2	82,86	FoxP3	IL-2	50943	3558	Gene	Gene	cells|amod|START_ENTITY promote|nsubj|cells promote|nmod|availability availability|compound|END_ENTITY	FoxP3 + regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability .
27049955	0	FoxP3	87,92	IL-2	47,51	FoxP3	IL-2	50943	3558	Gene	Gene	Suppression|compound|START_ENTITY Production|dep|Suppression Production|nsubj|Signaling Signaling|nmod|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
21745722	0	FoxP3	24,29	IL-7	0,4	FoxP3	IL-7	20371(Tax:10090)	16196(Tax:10090)	Gene	Gene	maintains|nsubj|START_ENTITY maintains|dep|END_ENTITY	IL-7 uniquely maintains FoxP3 -LRB- + -RRB- adaptive Treg cells that reverse diabetes in NOD mice via integrin-b7-dependent localization .
21413939	0	FoxP3	103,108	Interleukin-7	0,13	FoxP3	Interleukin-7	50943	3574	Gene	Gene	T|nmod|START_ENTITY T|dep|matures matures|nsubj|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	FoxP3	60,65	Interleukin-7	0,13	FoxP3	Interleukin-7	50943	3574	Gene	Gene	forkhead_box_P3|appos|START_ENTITY matures|dobj|forkhead_box_P3 matures|nsubj|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
25656537	0	FoxP3	83,88	RANKL	26,31	FoxP3	RANKL	20371(Tax:10090)	21943(Tax:10090)	Gene	Gene	Cells|nmod|START_ENTITY Cells|nsubj|Effect Effect|nmod|END_ENTITY	A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3 -LRB- + -RRB- CD8 T Cells .
17621372	0	FoxP3	39,44	SOCS3	10,15	FoxP3	SOCS3	50943	9021	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
24315995	0	FoxP3	0,5	STAT3	44,49	FoxP3	STAT3	50943	6774	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells .
27021296	0	FoxP3	11,16	T-bet	5,10	FoxP3	T-bet	20371(Tax:10090)	57765(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
24904415	0	FoxP3	9,14	TGF-b1	119,125	FoxP3	TGF-b1	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY inhibit|nsubj|Tregs inhibit|dobj|recruitment recruitment|nmod|suppression suppression|nmod|production production|nmod|lung lung|amod|exposed exposed|amod|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
26264613	0	FoxP3	0,5	TGF-b1	86,92	FoxP3	TGF-b1	50943	7040	Gene	Gene	START_ENTITY|nsubj|repression repression|nmod|END_ENTITY	FoxP3 in papillary_thyroid_carcinoma induces NIS repression through activation of the TGF-b1 / Smad signaling pathway .
16517699	0	FoxP3	65,70	TGF-beta	0,8	FoxP3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	induce|dobj|START_ENTITY requires|xcomp|induce requires|nsubj|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
17412560	0	FoxP3	125,130	TGF-beta	64,72	FoxP3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	transduction|amod|START_ENTITY cells|nmod|transduction producing|dobj|cells Converting|advcl|producing Converting|nmod|END_ENTITY	Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction .
20307666	0	FoxP3	137,142	TGF-beta1	35,44	FoxP3	TGF-beta1	50943	7040	Gene	Gene	Tregs|compound|START_ENTITY upregulation|nmod|Tregs responses|nmod|upregulation suppress|dobj|responses synergize|xcomp|suppress synergize|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta1 -RRB- and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3 + Tregs .
23628056	0	FoxP3	12,17	TLR2	53,57	FoxP3	TLR2	50943	7097	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	-LSB- Changes of FoxP3 , CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , TLR2 and TLR9 in children with infectious_mononucleosis -RSB- .
20173391	0	FoxP3	31,36	TNF-alpha	0,9	FoxP3	TNF-alpha	20371(Tax:10090)	21926(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activator|nmod|cells END_ENTITY|dep|activator	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
18453563	0	FoxP3	91,96	TNFR2	28,33	FoxP3	TNFR2	20371(Tax:10090)	21938(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY subset|nmod|cells defines|dobj|subset defines|nsubj|expression expression|nmod|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
20173391	0	FoxP3	31,36	TNFR2	37,42	FoxP3	TNFR2	20371(Tax:10090)	21938(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20525892	0	FoxP3	110,115	TNFR2	28,33	FoxP3	TNFR2	20371(Tax:10090)	21938(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|Expression Expression|nmod|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	FoxP3	60,65	TNFR2	28,33	FoxP3	TNFR2	20371(Tax:10090)	21938(Tax:10090)	Gene	Gene	resistance|nmod|START_ENTITY induces|dobj|resistance induces|nsubj|Expression Expression|nmod|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
23607606	0	FoxP3	75,80	forkhead_box_protein_3	51,73	FoxP3	forkhead box protein 3	50943	50943	Gene	Gene	+|appos|START_ENTITY +|amod|END_ENTITY	Thymus transplantation restores the repertoires of forkhead_box_protein_3 -LRB- FoxP3 -RRB- + and FoxP3 - T cells in complete_DiGeorge_anomaly .
24127318	0	FoxP3	59,64	hypoxia-inducible_factor_1_alpha	18,50	FoxP3	hypoxia-inducible factor 1 alpha	50943	3091	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Overexpression of hypoxia-inducible_factor_1_alpha impacts FoxP3 levels in mycosis fungoides -- cutaneous_T-cell_lymphoma : clinical implications .
25704764	0	FoxQ1	26,31	Sox12	0,5	FoxQ1	Sox12	94234	6666	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Sox12 , a direct target of FoxQ1 , promotes hepatocellular_carcinoma metastasis through up-regulating Twist1 and FGFBP1 .
14500912	0	Foxa-2	74,80	Insulin	0,7	Foxa-2	Insulin	3170	3630	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Insulin regulates the activity of forkhead transcription factor Hnf-3beta / Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization .
20348100	0	Foxa1	0,5	Afp	87,90	Foxa1	Afp	3169	174	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells .
21167261	0	Foxa1	30,35	C/EBPb	62,68	Foxa1	C/EBPb	15375(Tax:10090)	12608(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Forkhead transcription factor Foxa1 is a novel target gene of C/EBPb and suppresses the early phase of adipogenesis .
19486887	0	Foxa1	30,35	HSP72	21,26	Foxa1	HSP72	3169	3303	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast_cancer cell line .
16467259	0	Foxa1	0,5	androgen_receptor	34,51	Foxa1	androgen receptor	15375(Tax:10090)	11835(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Foxa1 and Foxa2 interact with the androgen_receptor to regulate prostate and epididymal genes differentially .
20382118	0	Foxa2	0,5	ALR	63,66	Foxa2	ALR	3170	2671	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Foxa2 -LRB- HNF-3beta -RRB- regulates expression of hepatotrophic factor ALR in liver cells .
23236435	0	Foxa2	106,111	Fat_mass_and_obesity_associated_gene	0,36	Foxa2	Fat mass and obesity associated gene	3170	79068	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Fat_mass_and_obesity_associated_gene -LRB- FTO -RRB- expression is regulated negatively by the transcription factor Foxa2 .
11287181	0	Foxa2	78,83	Hnf3beta	85,93	Foxa2	Hnf3beta	15376(Tax:10090)	15376(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of essential sequence motifs in the node/notochord enhancer of Foxa2 -LRB- Hnf3beta -RRB- gene that are conserved across vertebrate species .
20035737	0	Foxa2	31,36	Lmx1a	0,5	Foxa2	Lmx1a	15376(Tax:10090)	110648(Tax:10090)	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon .
23471965	0	Foxa2	28,33	Neurogenin3	0,11	Foxa2	Neurogenin3	3170	50674	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Neurogenin3 cooperates with Foxa2 to autoactivate its own expression .
26341558	0	Foxa2	0,5	Nkx2-1	30,36	Foxa2	Nkx2-1	3170	7080	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung_adenocarcinoma metastasis .
18753309	0	Foxa2	0,5	islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein	24,94	Foxa2	islet-specific glucose-6-phosphatase catalytic subunit-related protein	3170	57818	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Foxa2 and MafA regulate islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein gene expression .
14512019	0	Foxc1	51,56	Msx2	71,75	Foxc1	Msx2	17300(Tax:10090)	17702(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4 .
23344708	0	Foxc1	0,5	Msx2	114,118	Foxc1	Msx2	17300(Tax:10090)	17702(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|regulation regulation|nmod|threshold threshold|nmod|END_ENTITY	Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2 .
17506979	0	Foxc2	0,5	MyoD	28,32	Foxc2	MyoD	14234(Tax:10090)	17927(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Foxc2 induces expression of MyoD and differentiation of the mouse myoblast cell line C2C12 .
25587036	0	Foxc2	16,21	Notch1	0,6	Foxc2	Notch1	14234(Tax:10090)	18128(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium .
23645207	0	Foxc2	0,5	Wnt4	14,18	Foxc2	Wnt4	2303	54361	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis .
25220476	0	Foxd3	70,75	Forkhead_box_D3	48,63	Foxd3	Forkhead box D3	15221(Tax:10090)	15221(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Homeobox_b5 -LRB- Hoxb5 -RRB- regulates the expression of Forkhead_box_D3 gene -LRB- Foxd3 -RRB- in neural crest .
24307298	0	Foxe3	25,30	Pitx3	0,5	Foxe3	Pitx3	30923(Tax:10090)	18742(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Pitx3 directly regulates Foxe3 during early lens development .
23946491	0	Foxf1	25,30	serum_response_factor	40,61	Foxf1	serum response factor	15227(Tax:10090)	20807(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The transcription factor Foxf1 binds to serum_response_factor and myocardin to regulate gene transcription in visceral smooth muscle cells .
19297409	0	Foxg1	0,5	Gdf11	54,59	Foxg1	Gdf11	15228(Tax:10090)	14561(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11 .
17568773	0	Foxh1	0,5	Gsc	15,18	Foxh1	Gsc	14106(Tax:10090)	14836(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development .
16159312	0	Foxi1	34,39	AE4	63,66	Foxi1	AE4	14233(Tax:10090)	240215(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	The forkhead transcription factor Foxi1 directly activates the AE4 promoter .
23441037	0	Foxi3	14,19	ectodysplasin	36,49	Foxi3	ectodysplasin	232077(Tax:10090)	13607(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes .
19914232	0	Foxj3	0,5	Mef2c	34,39	Foxj3	Mef2c	230700(Tax:10090)	17260(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity .
20013826	0	Foxk1	20,25	Fhl2	0,4	Foxk1	Fhl2	17425(Tax:10090)	14200(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fhl2 interacts with Foxk1 and corepresses Foxo4 activity in myogenic progenitors .
19339816	0	Foxl2	30,35	DM-W	17,21	Foxl2	DM-W	100188926(Tax:8355)	100137717(Tax:8355)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Xenopus W-linked DM-W induces Foxl2 and Cyp19 expression during ovary formation .
23810756	0	Foxl2	66,71	MicroRNA-133b	0,13	Foxl2	MicroRNA-133b	668	442890	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2 .
19797124	0	Foxl2	0,5	estrogen_receptor-alpha	79,102	Foxl2	estrogen receptor-alpha	668	2099	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	Foxl2 , a forkhead transcription factor , modulates nonclassical activity of the estrogen_receptor-alpha .
16020526	0	Foxn4	0,5	Mash1	32,37	Foxn4	Mash1	121643	429	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord .
24244849	0	Foxn4	16,21	Meis1	0,5	Foxn4	Meis1	121643	4211	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation .
18347092	0	Foxn4	0,5	tbx2b	25,30	Foxn4	tbx2b	30315(Tax:7955)	30253(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Foxn4 directly regulates tbx2b expression and atrioventricular_canal_formation .
19211682	0	Foxo	32,36	Insulin_receptor	15,31	Foxo	Insulin receptor	41709(Tax:7227)	42549(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Integration of Insulin_receptor / Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila .
25330112	0	Foxo1	15,20	CD62L	53,58	Foxo1	CD62L	2308	6402	Gene	Gene	Activity|amod|START_ENTITY Activity|nmod|END_ENTITY	Suppression of Foxo1 Activity and Down-Modulation of CD62L -LRB- L-Selectin -RRB- in HIV-1 Infected Resting CD4 T Cells .
25353004	0	Foxo1	0,5	Dbh	16,19	Foxo1	Dbh	56458(Tax:10090)	13166(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Foxo1 regulates Dbh expression and the activity of the sympathetic nervous system in vivo .
13679577	0	Foxo1	41,46	FKHR	35,39	Foxo1	FKHR	2308	2308	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-induced phosphorylation of FKHR -LRB- Foxo1 -RRB- targets to proteasomal degradation .
23878308	0	Foxo1	36,41	MK5	0,3	Foxo1	MK5	2308	8550	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	MK5 activates Rag transcription via Foxo1 in developing B cells .
17202144	0	Foxo1	107,112	insulin	29,36	Foxo1	insulin	2308	3630	Gene	Gene	interactions|nmod|START_ENTITY signaling|nmod|interactions androgen|acl|signaling activates|dobj|androgen activates|nsubj|signaling signaling|compound|END_ENTITY	Insulin-like_growth_factor_1 / insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen_receptor .
17627282	0	Foxo1	0,5	insulin	12,19	Foxo1	insulin	2308	3630	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development .
16731820	0	Foxo1	18,23	insulin_receptor	32,48	Foxo1	insulin receptor	56458(Tax:10090)	16337(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Glucose regulates Foxo1 through insulin_receptor signaling in the pancreatic islet beta-cell .
17950246	0	Foxo1	0,5	musclin	30,37	Foxo1	musclin	56458(Tax:10090)	239790(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Foxo1 represses expression of musclin , a skeletal muscle-derived secretory factor .
15890677	0	Foxo1	75,80	p300	16,20	Foxo1	p300	2308	2033	Gene	Gene	acetylates|dobj|START_ENTITY acetylates|nsubj|END_ENTITY	The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription .
23390247	0	Foxo3a	50,56	Akt	21,24	Foxo3a	Akt	2309	207	Gene	Gene	translocation|amod|START_ENTITY signals|dobj|translocation signals|nsubj|inactivation inactivation|nmod|END_ENTITY	Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation , TRAIL gene induction , and potent antitumor effects .
15569384	0	Foxo3a	0,6	JNK	76,79	Foxo3a	JNK	2309	5599	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|nmod|cooperation cooperation|nmod|END_ENTITY	Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK .
15308101	0	Foxo3a	98,104	NF-kappaB	14,23	Foxo3a	NF-kappaB	56484(Tax:10090)	18033(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of NF-kappaB , Th activation , and autoinflammation by the forkhead transcription factor Foxo3a .
26063731	0	Foxp3	28,33	Androgen_receptor	0,17	Foxp3	Androgen receptor	50943	367	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	Foxp3	57,62	Androgen_receptor	0,17	Foxp3	Androgen receptor	50943	367	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells modulates|dobj|expression modulates|nsubj|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
23436577	0	Foxp3	44,49	Beta2-adrenergic_receptor	0,25	Foxp3	Beta2-adrenergic receptor	50943	154	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Beta2-adrenergic_receptor signaling in CD4 + Foxp3 + regulatory T cells enhances their suppressive function in a PKA-dependent manner .
15809349	0	Foxp3	15,20	CCR4	86,90	Foxp3	CCR4	20371(Tax:10090)	12773(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Recruitment|nmod|cells depends|nsubj|Recruitment depends|nmod|receptor receptor|compound|END_ENTITY	Recruitment of Foxp3 + T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor .
21945175	0	Foxp3	28,33	CCR4	0,4	Foxp3	CCR4	20371(Tax:10090)	12773(Tax:10090)	Gene	Gene	+|compound|START_ENTITY migration|nmod|+ migration|nummod|END_ENTITY	CCR4 dependent migration of Foxp3 + Treg cells to skin grafts and draining lymph nodes is implicated in enhanced graft survival in CD200tg recipients .
20181533	0	Foxp3	19,24	CCR6	14,18	Foxp3	CCR6	50943	1235	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Enrichment of CCR6 + Foxp3 + regulatory T cells in the tumor mass correlates with impaired CD8 + T cell function and poor prognosis of breast_cancer .
17698914	0	Foxp3	31,36	CCR7	0,4	Foxp3	CCR7	20371(Tax:10090)	12775(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY migration|nmod|cells mediates|dobj|migration mediates|nsubj|END_ENTITY	CCR7 mediates the migration of Foxp3 + regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules .
18724230	0	Foxp3	102,107	CCR7	56,60	Foxp3	CCR7	50943	1236	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|transplant_arteriosclerosis transplant_arteriosclerosis|nmod|absence absence|nmod|END_ENTITY	Increased transplant_arteriosclerosis in the absence of CCR7 is associated with reduced expression of Foxp3 .
22067914	0	Foxp3	55,60	CCR7	0,4	Foxp3	CCR7	20371(Tax:10090)	12775(Tax:10090)	Gene	Gene	T-cells|amod|START_ENTITY migration|nmod|T-cells AP-1|nmod|migration signaling|nmod|AP-1 S1P1|acl|signaling END_ENTITY|nmod|S1P1	CCR7 with S1P1 signaling through AP-1 for migration of Foxp3 + regulatory T-cells controls autoimmune exocrinopathy .
26832402	0	Foxp3	74,79	CCR7	0,4	Foxp3	CCR7	20371(Tax:10090)	12775(Tax:10090)	Gene	Gene	T|compound|START_ENTITY Recirculation|nmod|T Recirculation|compound|END_ENTITY	CCR7 Controls Thymus Recirculation , but Not Production and Emigration , of Foxp3 -LRB- + -RRB- T Cells .
17620361	0	Foxp3	68,73	CD103	49,54	Foxp3	CD103	50943	3682	Gene	Gene	cells|amod|START_ENTITY induces|dobj|cells induces|nsubj|population population|nmod|DCs DCs|compound|END_ENTITY	A functionally specialized population of mucosal CD103 + DCs induces Foxp3 + regulatory T cells via a TGF-beta and retinoic_acid-dependent mechanism .
19079226	0	Foxp3	24,29	CD103	0,5	Foxp3	CD103	50943	3682	Gene	Gene	cells|amod|START_ENTITY promote|dobj|cells promote|nsubj|DCs DCs|compound|END_ENTITY	CD103 + GALT DCs promote Foxp3 + regulatory T cells .
23126599	0	Foxp3	47,52	CD103	31,36	Foxp3	CD103	50943	3682	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
23733880	0	Foxp3	132,137	CD103	78,83	Foxp3	CD103	20371(Tax:10090)	16407(Tax:10090)	Gene	Gene	novo|compound|START_ENTITY induce|dobj|novo retinaldehyde|advcl|induce retinaldehyde|dobj|cells cells|amod|dehydrogenase dehydrogenase|nmod|+ +|compound|END_ENTITY	Cutting edge : inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103 + but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4 + T cells and promote airway tolerance .
23861553	0	Foxp3	68,73	CD103	75,80	Foxp3	CD103	50943	3682	Gene	Gene	characteristic|nmod|START_ENTITY characteristic|dep|+ +|compound|END_ENTITY	Phenotypic and functional characteristic of a newly identified CD8 + Foxp3 - CD103 + regulatory T cells .
20332626	0	Foxp3	30,35	CD127	36,41	Foxp3	CD127	50943	3575	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Defective circulating CD4CD25 + Foxp3 + CD127 -LRB- low -RRB- regulatory T-cells in patients with chronic_heart_failure .
22749982	0	Foxp3	54,59	CD152	13,18	Foxp3	CD152	50943	1493	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
23017670	0	Foxp3	11,16	CD178	24,29	Foxp3	CD178	50943	356	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
12612578	0	Foxp3	0,5	CD25	51,55	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	programs|amod|START_ENTITY programs|dep|development development|nmod|cells cells|compound|END_ENTITY	Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells .
14676299	0	Foxp3	127,132	CD25	29,33	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY +|nmod|induction CD25|acl|+ cells|nmod|CD25 Conversion|dep|cells Conversion|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	Foxp3	127,132	CD25	56,60	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY +|nmod|induction END_ENTITY|acl|+	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15237110	0	Foxp3	124,129	CD25	130,134	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|amod|START_ENTITY CD4|compound|END_ENTITY	Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3 + CD25 + CD4 + regulatory T cells .
15240741	0	Foxp3	0,5	CD25	21,25	Foxp3	CD25	50943	3559	Gene	Gene	START_ENTITY|xcomp|expressing expressing|dobj|END_ENTITY	Foxp3 expressing CD4 + CD25 -LRB- high -RRB- regulatory T cells are overrepresented in human metastatic_melanoma lymph nodes and inhibit the function of infiltrating T cells .
15367216	0	Foxp3	17,22	CD25	55,59	Foxp3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY induces|dobj|cells induces|nmod|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
15520045	0	Foxp3	11,16	CD25	18,22	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Control of Foxp3 + CD25 + CD4 + regulatory cell activation and function by dendritic cells .
15585848	0	Foxp3	28,33	CD25	0,4	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY generate|ccomp|+ END_ENTITY|parataxis|generate	CD25 - T cells generate CD25 + Foxp3 + regulatory T cells by peripheral expansion .
15753206	0	Foxp3	35,40	CD25	44,48	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|amod|START_ENTITY CD4|compound|END_ENTITY	Homeostatic maintenance of natural Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells by interleukin _ -LRB- IL -RRB- -2 and induction of autoimmune_disease by IL-2 neutralization .
15753306	0	Foxp3	0,5	CD25	90,94	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|parataxis|constitute constitute|dobj|reservoir reservoir|acl:relcl|regain regain|dobj|expression expression|compound|END_ENTITY	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15851684	0	Foxp3	100,105	CD25	17,21	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY +|nmod|activation +|nsubj|Induction Induction|nmod|END_ENTITY	Induction of CD4 + CD25 + regulatory T cells by copolymer-I through activation of transcription factor Foxp3 .
15912097	0	Foxp3	70,75	CD25	44,48	Foxp3	CD25	50943	3559	Gene	Gene	transfer|amod|START_ENTITY cells|nmod|transfer END_ENTITY|dep|cells	Regulatory T cells , derived from na ve CD4 + CD25 - T cells by in vitro Foxp3 gene transfer , can induce transplantation tolerance .
16186187	0	Foxp3	96,101	CD25	102,106	Foxp3	GITR	20371(Tax:10090)	21936(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Treatment of advanced_tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3 + CD25 + CD4 + regulatory T cells .
16473944	0	Foxp3	44,49	CD25	51,55	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Effective expansion of alloantigen-specific Foxp3 + CD25 + CD4 + regulatory T cells by dendritic cells during the mixed leukocyte reaction .
16698419	0	Foxp3	0,5	CD25	22,26	Foxp3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Foxp3 expressing CD4 + CD25 + and CD8 + CD28 - T regulatory cells in the peripheral blood of patients with lung_cancer and pleural_mesothelioma .
16709816	0	Foxp3	9,14	CD25	4,8	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T cells and CD4 + CD25-Foxp3 + T cells in aged mice .
16751356	0	Foxp3	34,39	CD25	29,33	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : allogeneic CD4 + CD25 + Foxp3 + T regulatory cells suppress autoimmunity while establishing transplantation tolerance .
16785516	0	Foxp3	98,103	CD25	58,62	Foxp3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells leads|nmod|induction overexpression|parataxis|leads overexpression|nmod|END_ENTITY	G_protein-coupled_receptor_83 overexpression in naive CD4 + CD25 - T cells leads to the induction of Foxp3 + regulatory T cells in vivo .
16890606	0	Foxp3	6,11	CD25	0,4	Foxp3	CD25	50943	16184(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	CD25 + / Foxp3 + T cells regulate gastric_inflammation and Helicobacter_pylori colonization in vivo .
16903903	0	Foxp3	0,5	CD25	7,11	Foxp3	CD25	50943	3559	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Foxp3 + CD25 + CD4 + natural regulatory T cells in dominant self-tolerance and autoimmune_disease .
16903923	0	Foxp3	40,45	CD25	47,51	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Dendritic cells expand antigen-specific Foxp3 + CD25 + CD4 + regulatory T cells including suppressors of alloreactivity .
16906223	0	Foxp3	34,39	CD25	63,67	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY IFN-gamma|nmod|induction Role|nmod|IFN-gamma Role|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16914538	0	Foxp3	79,84	CD25	74,78	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel mechanism of action for anti-thymocyte globulin : induction of CD4 + CD25 + Foxp3 + regulatory T cells .
16918694	0	Foxp3	90,95	CD25	96,100	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Sublingual tolerance induction with antigen conjugated to cholera_toxin_B subunit induces Foxp3 + CD25 + CD4 + regulatory T cells and suppresses delayed-type_hypersensitivity reactions .
16943258	0	Foxp3	65,70	CD25	60,64	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	An MHC-linked locus modulates thymic differentiation of CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
17015695	0	Foxp3	93,98	CD25	88,92	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17056509	0	Foxp3	20,25	CD25	30,34	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of Foxp3 + CD4 + CD25 + and IL-10-secreting CD4 + CD25 + T cells during cure of colitis .
17082572	0	Foxp3	101,106	CD25	96,100	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cyclophosphamide-induced type-1_diabetes in the NOD mouse is associated with a reduction of CD4 + CD25 + Foxp3 + regulatory T cells .
17114433	0	Foxp3	91,96	CD25	97,101	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Oral tolerance induction with antigen conjugated to cholera_toxin_B_subunit generates both Foxp3 + CD25 + and Foxp3-CD25 - CD4 + regulatory T cells .
17277105	0	Foxp3	72,77	CD25	52,56	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells END_ENTITY|dep|cells	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17277105	0	Foxp3	72,77	CD25	67,71	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17309822	0	Foxp3	43,48	CD25	70,74	Foxp3	CD25	50943	3669	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4 + CD25 - T lymphocytes .
17316678	0	Foxp3	41,46	CD25	36,40	Foxp3	CD25	50943	3669	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The clonal composition of human CD4 + CD25 + Foxp3 + cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements .
17350019	0	Foxp3	22,27	CD25	16,20	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells expand during experimental Plasmodium infection but do not prevent cerebral_malaria .
17371960	0	Foxp3	58,63	CD25	52,56	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Function of the IL-2R for thymic and peripheral CD4 + CD25 + Foxp3 + T regulatory cells .
17389235	0	Foxp3	71,76	CD25	64,68	Foxp3	CD25	50943	3559	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17428252	0	Foxp3	94,99	CD25	88,92	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Diabetes_in_non-obese diabetic mice is not associated with quantitative changes in CD4 + CD25 + Foxp3 + regulatory T cells .
17453966	0	Foxp3	46,51	CD25	30,34	Foxp3	CD25	50943	3559	Gene	Gene	enriches|dobj|START_ENTITY enriches|nmod|END_ENTITY	Rapamycin enriches for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD27 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple_sclerosis .
17545218	0	Foxp3	96,101	CD25	91,95	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17615291	0	Foxp3	42,47	CD25	103,107	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
17641007	0	Foxp3	99,104	CD25	94,98	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17684039	0	Foxp3	78,83	CD25	73,77	Foxp3	CD25	50943	3559	Gene	Gene	START_ENTITY|amod|graft-versus-host_disease graft-versus-host_disease|nmod|+ +|compound|END_ENTITY	Blockade of chronic graft-versus-host_disease by alloantigen-induced CD4 + CD25 + Foxp3 + regulatory T cells in nonlymphopenic hosts .
17687106	0	Foxp3	113,118	CD25	108,112	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4 + CD25 + Foxp3 + regulatory T cells .
17688698	0	Foxp3	68,73	CD25	131,135	Foxp3	CD25	50943	3559	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
17785792	0	Foxp3	77,82	CD25	57,61	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells suppression|nmod|transcription transcription|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17875988	0	Foxp3	31,36	CD25	25,29	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells END_ENTITY|acl|+	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	Foxp3	31,36	CD25	65,69	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17911604	0	Foxp3	64,69	CD25	59,63	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18054287	0	Foxp3	28,33	CD25	18,22	Foxp3	CD25	50943	3559	Gene	Gene	START_ENTITY|nsubj|Decrease Decrease|nmod|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and elevation of CD19 -LRB- + -RRB- BAFF-R -LRB- + -RRB- B cells and soluble ICAM-1 in myasthenia_gravis .
18056346	0	Foxp3	86,91	CD25	92,96	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3 CD25 regulatory T cells .
18159952	0	Foxp3	178,183	CD25	173,177	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Repeated 0.5-Gy gamma irradiation attenuates autoimmune_disease in MRL-lpr/lpr mice with suppression of CD3 + CD4-CD8-B220 + T-cell proliferation and with up-regulation of CD4 + CD25 + Foxp3 + regulatory T cells .
18256318	0	Foxp3	108,113	CD25	103,107	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Autologous bone marrow transplantation in autoimmune_arthritis restores immune homeostasis through CD4 + CD25 + Foxp3 + regulatory T cells .
18304352	0	Foxp3	24,29	CD25	19,23	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The control of CD4 + CD25 + Foxp3 + regulatory T cell survival .
18431238	0	Foxp3	91,96	CD25	86,90	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depleting anti-CD4 monoclonal antibody -LRB- GK1 .5 -RRB- treatment : influence on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
18462346	0	Foxp3	69,74	CD25	63,67	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
18477692	0	Foxp3	75,80	CD25	70,74	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18477692	0	Foxp3	95,100	CD25	70,74	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|amod|IL-1 IL-1|nmod|expansion/differentiation expansion/differentiation|nmod|+ +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18480441	0	Foxp3	47,52	CD25	41,45	Foxp3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-generated antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells control the severity of herpes simplex virus-induced ocular_immunoinflammatory_lesions .
18510697	0	Foxp3	0,5	CD25	44,48	Foxp3	CD25	50943	3669	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Foxp3 expression on normal and leukemic CD4 + CD25 + T cells implicated in human T-cell_leukemia_virus_type-1 is inconsistent with Treg cells .
18566388	0	Foxp3	34,39	CD25	29,33	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18641303	0	Foxp3	104,109	CD25	50,54	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY repressing|dobj|expression regulates|advcl|repressing regulates|dobj|differentiation differentiation|compound|END_ENTITY	IFN regulatory factor-1 negatively regulates CD4 + CD25 + regulatory T cell differentiation by repressing Foxp3 expression .
18658093	0	Foxp3	27,32	CD25	22,26	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expanded CD4 + CD25 + Foxp3 + regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation .
18792402	0	Foxp3	34,39	CD25	29,33	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Resting B cells expand a CD4 + CD25 + Foxp3 + Treg population via TGF-beta3 .
18832672	0	Foxp3	95,100	CD25	89,93	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CD47 controls the in vivo proliferation and homeostasis of peripheral CD4 + CD25 + Foxp3 + regulatory T cells that express CD103 .
18981109	0	Foxp3	17,22	CD25	11,15	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + Foxp3 + regulatory T cells do not constitutively express IL-35 .
18981295	0	Foxp3	85,90	CD25	80,84	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4 + CD25 + Foxp3 + T regulatory cells in mycobacterial_infection .
19022917	0	Foxp3	27,32	CD25	22,26	Foxp3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal_cancer tissue .
19146957	0	Foxp3	60,65	CD25	55,59	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	The significantly enhanced frequency of functional CD4 + CD25 + Foxp3 + T regulatory cells in therapeutic dose aspirin-treated mice .
19153062	0	Foxp3	53,58	CD25	6,10	Foxp3	CD25	50943	3559	Gene	Gene	express|dobj|START_ENTITY cells|dep|express CD127|dobj|cells CD127|nsubj|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric_cancers progression .
19155519	0	Foxp3	49,54	CD25	43,47	Foxp3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY analysis|dep|cells analysis|nmod|END_ENTITY	Phenotypic and functional analysis of CD4 + CD25 - Foxp3 + T cells in patients with systemic_lupus_erythematosus .
19221040	0	Foxp3	90,95	CD25	85,89	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4 + CD25 + Foxp3 + T regulatory cells that protects against graft-versus-host_disease .
19229109	0	Foxp3	36,41	CD25	31,35	Foxp3	CD25	50943	3559	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
19234174	0	Foxp3	127,132	CD25	122,126	Foxp3	CD25	50943	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human dendritic cells produce TGF-beta_1 under the influence of lung_carcinoma cells and prime the differentiation of CD4 + CD25 + Foxp3 + regulatory T cells .
19364517	0	Foxp3	19,24	CD25	14,18	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + T cells in peripheral blood of celiac_disease patients : correlation with dietary treatment .
19448155	0	Foxp3	26,31	CD25	21,25	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
19535644	0	Foxp3	127,132	CD25	121,125	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4 + CD25 + Foxp3 + T regulatory cells .
19609976	0	Foxp3	53,58	CD25	48,52	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|numbers numbers|nmod|END_ENTITY	Increased numbers of thymic and peripheral CD4 + CD25 + Foxp3 + cells in the absence of CD5 signaling .
19665867	0	Foxp3	101,106	CD25	96,100	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4 + CD25 + Foxp3 + regulatory T cell population .
19706340	0	Foxp3	70,75	CD25	65,69	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naloxone can improve the anti-tumor immunity by reducing the CD4 + CD25 + Foxp3 + regulatory T cells in BALB/c mice .
19709757	0	Foxp3	32,37	CD25	27,31	Foxp3	CD25	50943	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of inducible CD4 + CD25 + Foxp3 + regulatory T lymphocytes by porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- .
19740328	0	Foxp3	148,153	CD25	142,146	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4 + CD25 + Foxp3 + regulatory T cells .
19770521	0	Foxp3	9,14	CD25	4,8	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Tregs resolve experimental lung_injury in mice and are present in humans with acute_lung_injury .
19841169	0	Foxp3	79,84	CD25	74,78	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Skin_melanoma development in ret transgenic_mice despite the depletion of CD25 + Foxp3 + regulatory T cells in lymphoid organs .
19845018	0	Foxp3	18,23	CD25	102,106	Foxp3	CD25	50943	3559	Gene	Gene	antibody|amod|START_ENTITY importance|nmod|antibody importance|acl|identifying identifying|dobj|Foxp3 Foxp3|compound|END_ENTITY	The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4 + CD25 + Foxp3 + regulatory T cells .
19953886	0	Foxp3	58,63	CD25	15,19	Foxp3	CD25	50943	3559	Gene	Gene	mRNA|amod|START_ENTITY +|nmod|mRNA +|nsubj|Study Study|nmod|END_ENTITY	-LSB- Study of CD4 + CD25 + regulatory T cells and expression of Foxp3 mRNA in bronchiolitis and glucocorticoid regulation -RSB- .
19961805	0	Foxp3	38,43	CD25	26,30	Foxp3	CD25	50943	3559	Gene	Gene	comparison|dep|START_ENTITY comparison|dep|END_ENTITY	-LSB- The comparison of CD4 -LRB- + -RRB- ; CD25 -LRB- high -RRB- ; Foxp3 -LRB- + -RRB- ; regulatory T cells between neonatal cord blood and adult peripheral blood . -RSB- .
20081380	0	Foxp3	70,75	CD25	64,68	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20306694	0	Foxp3	8,13	CD25	33,37	Foxp3	CD25	50943	3559	Gene	Gene	Role|nmod|START_ENTITY +|nsubj|Role +|dobj|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Role of Foxp3 and regulatory CD4 + CD25 + T-lymphocytes in bronchial_asthma .
20332205	0	Foxp3	100,105	CD25	95,99	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Hepatocyte_growth_factor inhibits CNS autoimmunity by inducing tolerogenic dendritic cells and CD25 + Foxp3 + regulatory T cells .
20357481	0	Foxp3	22,27	CD25	17,21	Foxp3	CD25	50943	3559	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + IL-10 + T cells in HDM-allergic asthmatic children with or without SIT .
20378024	0	Foxp3	9,14	CD25	4,8	Foxp3	CD25	506053(Tax:9913)	281861(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T regulatory cells are not involved in oral desensitization .
20382706	0	Foxp3	23,28	CD25	17,21	Foxp3	CD25	50943	3559	Gene	Gene	IFN-gamma|dep|START_ENTITY IFN-gamma|compound|END_ENTITY	Antigen-specific CD25 - Foxp3 - IFN-gamma -LRB- high -RRB- CD4 + T cells restrain the development of experimental_allergic_encephalomyelitis by suppressing Th17 .
20382886	0	Foxp3	65,70	CD25	59,63	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20394727	0	Foxp3	129,134	CD25	124,128	Foxp3	CD25	50943	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4 + CD25 + Foxp3 + regulatory T cells and down-regulates cardiac allograft rejection .
20497692	0	Foxp3	4,9	CD25	73,77	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|converted converted|nmod|END_ENTITY	CD4 + Foxp3 + regulatory T cells converted by rapamycin from peripheral CD4 + CD25 -LRB- - -RRB- naive T cells display more potent regulatory ability in vitro .
20522244	0	Foxp3	0,5	CD25	34,38	Foxp3	CD25	50943	3559	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|suppression suppression|compound|END_ENTITY	Foxp3 regulates human natural CD4 + CD25 + regulatory T-cell-mediated suppression of xenogeneic response .
20693259	0	Foxp3	16,21	CD25	11,15	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Numbers of CD25 + Foxp3 + T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients .
20713627	0	Foxp3	11,16	CD25	5,9	Foxp3	CD25	50943	3559	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells , dendritic cells , and circulating cytokines in uncomplicated malaria : do different parasite species elicit similar host responses ?
20729905	0	Foxp3	49,54	CD25	44,48	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antigen-non-specific regulation centered on CD25 + Foxp3 + Treg cells .
20832552	0	Foxp3	76,81	CD25	65,69	Foxp3	CD25	50943	3559	Gene	Gene	START_ENTITY|amod|Influence Influence|nmod|drugs drugs|nmod|development development|nmod|END_ENTITY	Influence of immunosuppressive drugs on the development of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells in liver transplant recipients .
20848841	0	Foxp3	93,98	CD25	33,37	Foxp3	CD25	50943	3559	Gene	Gene	expression|nmod|START_ENTITY +|nmod|expression +|nsubj|Studies Studies|nmod|level level|nmod|END_ENTITY	-LSB- Studies about the level of CD4 + CD25 + regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV_infection -RSB- .
20871628	0	Foxp3	107,112	CD25	101,105	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	2-Gy whole-body irradiation significantly alters the balance of CD4 + CD25 - T effector cells and CD4 + CD25 + Foxp3 + T regulatory cells in mice .
21072213	0	Foxp3	9,14	CD25	4,8	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells depletion may attenuate the development of silica-induced lung_fibrosis in mice .
21314851	0	Foxp3	31,36	CD25	23,27	Foxp3	CD25	50943	3559	Gene	Gene	T|nsubj|START_ENTITY T|dep|circulating circulating|dobj|END_ENTITY	Low circulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- _ Foxp3 -LRB- + -RRB- T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure .
21447271	0	Foxp3	10,15	CD25	5,9	Foxp3	CD25	50943	3559	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- CD4 + CD25 + Foxp3 + T lymphocytes : naturally occuring regulatory T cells -RSB- .
21469094	0	Foxp3	122,127	CD25	116,120	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Steady state migratory RelB + langerin + dermal dendritic cells mediate peripheral induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells .
21472340	0	Foxp3	67,72	CD25	91,95	Foxp3	CD25	50943	3559	Gene	Gene	START_ENTITY|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	Foxp3	96,101	CD25	91,95	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21519344	0	Foxp3	26,31	CD25	19,23	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Induction|nmod|cells Induction|nmod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21600126	0	Foxp3	23,28	CD25	33,37	Foxp3	CD25	50943	3559	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Study of fas-mediated Foxp3 + CD4 + CD25 + Treg cell apoptosis in patients with systemic_lupus_erythematosus -RSB- .
21604971	0	Foxp3	69,74	CD25	76,80	Foxp3	CD25	50943	3559	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Transfer of cell membrane components via trogocytosis occurs in CD4 + Foxp3 + CD25 + regulatory T-cell contact-dependent suppression .
21604973	0	Foxp3	34,39	CD25	29,33	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Decreased frequencies of CD4 + CD25 + Foxp3 + cells and the potent CD103 + subset in peripheral lymph_nodes correlate with autoimmune_disease predisposition in some strains of mice .
21726337	0	Foxp3	9,14	CD25	31,35	Foxp3	CD25	50943	3669	Gene	Gene	START_ENTITY|acl|expressing expressing|dobj|+ +|compound|END_ENTITY	Maternal Foxp3 expressing CD4 + CD25 + and CD4 + CD25 - regulatory T-cell populations are enriched in human early normal pregnancy decidua : a phenotypic study of paired decidual and peripheral blood samples .
21734238	0	Foxp3	124,129	CD25	119,123	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin and IL-2 reduce lethal acute_graft-versus-host_disease associated with increased expansion of donor type CD4 + CD25 + Foxp3 + regulatory T cells .
21843083	0	Foxp3	41,46	CD25	36,40	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Neem leaf glycoprotein inhibits CD4 + CD25 + Foxp3 + Tregs to restrict murine tumor growth .
21983870	0	Foxp3	35,40	CD25	30,34	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations of peripheral CD4 + CD25 + Foxp3 + T regulatory cells in mice with STZ-induced diabetes .
22005288	0	Foxp3	24,29	CD25	18,22	Foxp3	CD25	50943	3669	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
22079196	0	Foxp3	0,5	CD25	40,44	Foxp3	CD25	50943	3559	Gene	Gene	critical|nsubj|START_ENTITY critical|nmod|cells cells|compound|END_ENTITY	Foxp3 is critical for human natural CD4 + CD25 + regulatory T cells to suppress alloimmune response .
22098165	0	Foxp3	0,5	CD25	14,18	Foxp3	CD25	50943	3559	Gene	Gene	CD4|compound|START_ENTITY END_ENTITY|nsubj|CD4	Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells are increased in patients with Coxiella_burnetii_endocarditis .
22164498	0	Foxp3	74,79	CD25	68,72	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of excreted/secreted antigens of Toxoplasma_gondii on CD4 + CD25 + Foxp3 + T cells and NK cells of melanoma-bearing mice -RSB- .
22564624	0	Foxp3	88,93	CD25	80,84	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|cytotoxicity cytotoxicity|nmod|cell cell|nmod|END_ENTITY	Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4 CD25 Foxp3 regulatory T cells in vitro .
22609353	0	Foxp3	73,78	CD25	68,72	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22672991	0	Foxp3	0,5	CD25	6,10	Foxp3	CD25	50943	3559	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Foxp3 + CD25 -LRB- high -RRB- CD4 + regulatory T cells from indeterminate patients with Chagas_disease can suppress the effector cells and cytokines and reveal altered correlations with disease severity .
22749982	0	Foxp3	54,59	CD25	66,70	Foxp3	CD25	50943	3559	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22873180	0	Foxp3	122,127	CD25	117,121	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic_dermatitis via generation of CD4 + CD25 + Foxp3 + T cells .
22921804	0	Foxp3	37,42	CD25	30,34	Foxp3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Increased proportion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells during early-stage sepsis in ICU patients .
23017670	0	Foxp3	11,16	CD25	5,9	Foxp3	CD25	50943	3669	Gene	Gene	Treg|compound|START_ENTITY END_ENTITY|acl:relcl|Treg	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
23041608	0	Foxp3	128,133	CD25	123,127	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activation of the aryl_hydrocarbon_receptor reduces the number of precursor and effector T cells , but preserves thymic CD4 + CD25 + Foxp3 + regulatory T cells .
23059841	0	Foxp3	0,5	CD25	76,80	Foxp3	CD25	506053(Tax:9913)	281861(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|intensity intensity|nmod|expression expression|compound|END_ENTITY	Foxp3 expression in bovine CD8 + T cells is associated with the intensity of CD25 expression .
23185797	0	Foxp3	9,14	CD25	4,8	Foxp3	CD25	50943	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Treg and TGF-beta play important roles in pathogenesis of Uygur cervical_carcinoma .
23421612	0	Foxp3	36,41	CD25	31,35	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased bronchial density of CD25 + Foxp3 + regulatory T cells in occupational asthma : relationship to current smoking .
23559897	0	Foxp3	54,59	CD25	68,72	Foxp3	CD25	50943	3669	Gene	Gene	Activity|nmod|START_ENTITY Activity|dep|END_ENTITY	Ribavirin Does Not Impair the Suppressive Activity of Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Regulatory T Cells .
23734780	0	Foxp3	43,48	CD25	38,42	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
23749427	0	Foxp3	66,71	CD25	60,64	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
23881298	0	Foxp3	9,14	CD25	4,8	Foxp3	CD25	50943	3559	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	CD4 + CD25 + Foxp3 regulatory T cells and vascular_dysfunction in hypertension .
23949701	0	Foxp3	35,40	CD25	28,32	Foxp3	CD25	50943	3559	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute_respiratory_distress_syndrome is associated with increased 30-day mortality .
24339053	0	Foxp3	151,156	CD25	145,149	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
24366217	0	Foxp3	169,174	CD25	162,166	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin _ D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4 CD25 Foxp3 regulatory T cells .
24452947	0	Foxp3	44,49	CD25	38,42	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24557710	0	Foxp3	137,142	CD25	132,136	Foxp3	CD25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Narrowband ultraviolet B phototherapy ameliorates acute_graft-versus-host_disease by a mechanism involving in vivo expansion of CD4 + CD25 + Foxp3 + regulatory T cells .
24617045	0	Foxp3	29,34	CD25	23,27	Foxp3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|Role Role|nmod|END_ENTITY	Role of regulatory CD4 + CD25 + Foxp3 T cells in bronchial asthma in Egyptian children .
24716598	0	Foxp3	56,61	CD25	65,69	Foxp3	CD25	50943	3559	Gene	Gene	CD4|amod|START_ENTITY CD4|amod|END_ENTITY	Decreased expression of Runx1 and lowered proportion of Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells in systemic_sclerosis .
24813240	0	Foxp3	104,109	CD25	95,99	Foxp3	CD25	50943	3559	Gene	Gene	Interleukin-17|dep|START_ENTITY Interleukin-17|dep|facilitates facilitates|dobj|capacity capacity|nmod|END_ENTITY	Interleukin-17 facilitates the immune suppressor capacity of high-grade glioma-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells via releasing transforming_growth_factor_beta .
24931519	0	Foxp3	19,24	CD25	44,48	Foxp3	CD25	50943	3559	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
25030097	0	Foxp3	62,67	CD25	55,59	Foxp3	CD25	50943	3559	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Comment on Adamzik et al. : An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory_distress_syndrome is associated with increased 30-day mortality .
25054604	0	Foxp3	134,139	CD25	127,131	Foxp3	CD25	50943	3559	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Patients with systemic_lupus_erythematosus and secondary_antiphospholipid_syndrome have decreased numbers of circulating CD4 CD25 Foxp3 Treg and CD3 CD19 B cells .
25523632	0	Foxp3	23,28	CD25	31,35	Foxp3	CD25	50943	3559	Gene	Gene	Extension|nmod|START_ENTITY END_ENTITY|nsubj|Extension	Extension of the CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- CD25 -LRB- - / low -RRB- regulatory T-cell subpopulation in type_1_diabetes_mellitus .
25560411	0	Foxp3	104,109	CD25	55,59	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
25595257	0	Foxp3	100,105	CD25	95,99	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4 + CD25 + Foxp3 + T cells -LRB- Tregs -RRB- in a mouse study for active DNA Ab42 immunotherapy .
26063731	0	Foxp3	28,33	CD25	52,56	Foxp3	CD25	50943	3559	Gene	Gene	expression|amod|START_ENTITY expression|nmod|T-cells T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	Foxp3	57,62	CD25	52,56	Foxp3	CD25	50943	3559	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26273136	0	Foxp3	42,47	CD25	35,39	Foxp3	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	Cells|nsubj|START_ENTITY END_ENTITY|xcomp|Cells	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
26438270	0	Foxp3	106,111	CD25	99,103	Foxp3	CD25	50943	3669	Gene	Gene	generation|amod|START_ENTITY correlates|dobj|generation correlates|nmod|END_ENTITY	Up-regulated S100_calcium_binding_protein_A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
26862849	0	Foxp3	22,27	CD25	17,21	Foxp3	CD25	50943	3559	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|Frequency Frequency|nmod|END_ENTITY	Frequency of CD4 + CD25 + Foxp3 + cells in peripheral blood in relation to urinary bladder_cancer malignancy indicators before and after surgical removal .
23874626	0	Foxp3	77,82	CD38	70,74	Foxp3	CD38	50943	952	Gene	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in natural Foxp3 -LRB- + -RRB- Treg but not mucosally-imprinted CD62L -LRB- neg -RRB- CD38 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Treg in the circulation of celiac_disease patients .
17449799	0	Foxp3	39,44	CD39	31,35	Foxp3	CD39	50943	953	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Expression of ectonucleotidase CD39 by Foxp3 + Treg cells : hydrolysis of extracellular ATP and immune suppression .
12612578	0	Foxp3	0,5	CD4	47,50	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	programs|amod|START_ENTITY programs|dep|development development|nmod|cells cells|compound|END_ENTITY	Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells .
14676299	0	Foxp3	127,132	CD4	25,28	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY +|nmod|induction CD25|acl|+ cells|nmod|CD25 Conversion|dep|cells Conversion|nmod|CD25 CD25|compound|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	Foxp3	127,132	CD4	52,55	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY +|nmod|induction CD25|acl|+ CD25|compound|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15100250	0	Foxp3	83,88	CD4	57,60	Foxp3	CD4	50943	920	Gene	Gene	induction|amod|START_ENTITY cells|nmod|induction phenotype|dep|cells phenotype|nmod|CD25 CD25|compound|END_ENTITY	Cutting edge : TGF-beta induces a regulatory phenotype in CD4 + CD25 - T cells through Foxp3 induction and down-regulation of Smad7 .
15240741	0	Foxp3	0,5	CD4	17,20	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|xcomp|expressing expressing|dobj|CD25 CD25|compound|END_ENTITY	Foxp3 expressing CD4 + CD25 -LRB- high -RRB- regulatory T cells are overrepresented in human metastatic_melanoma lymph nodes and inhibit the function of infiltrating T cells .
15367216	0	Foxp3	17,22	CD4	49,52	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY induces|dobj|cells induces|nmod|CD25 CD25|compound|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
15520045	0	Foxp3	11,16	CD4	23,26	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Control of Foxp3 + CD25 + CD4 + regulatory cell activation and function by dendritic cells .
15753306	0	Foxp3	0,5	CD4	13,16	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|parataxis|constitute constitute|nsubj|cells cells|compound|END_ENTITY	Foxp3 + CD25 - CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion .
15793242	0	Foxp3	83,88	CD4	54,57	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	expressing|dobj|START_ENTITY T-cells|acl|expressing +|dobj|T-cells +|nsubj|control control|nmod|diabetogenic_T-cells diabetogenic_T-cells|nmod|END_ENTITY	In vivo control of diabetogenic_T-cells by regulatory CD4 + CD25 + T-cells expressing Foxp3 .
15851684	0	Foxp3	100,105	CD4	13,16	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY +|nmod|activation +|nsubj|Induction Induction|nmod|CD25 CD25|compound|END_ENTITY	Induction of CD4 + CD25 + regulatory T cells by copolymer-I through activation of transcription factor Foxp3 .
15912097	0	Foxp3	70,75	CD4	40,43	Foxp3	CD4	50943	920	Gene	Gene	transfer|amod|START_ENTITY cells|nmod|transfer CD25|dep|cells CD25|compound|END_ENTITY	Regulatory T cells , derived from na ve CD4 + CD25 - T cells by in vitro Foxp3 gene transfer , can induce transplantation tolerance .
16272276	0	Foxp3	86,91	CD4	79,82	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Murine vascular endothelium activates and induces the generation of allogeneic CD4 +25 + Foxp3 + regulatory T cells .
16478885	0	Foxp3	0,5	CD4	6,9	Foxp3	CD4	740909(Tax:9598)	450124(Tax:9598)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	Foxp3 + CD4 + CD25 + T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis_C .
16670295	0	Foxp3	5,10	CD4	42,45	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|facilitate facilitate|xcomp|induction induction|nsubj|clonal clonal|compound|END_ENTITY	CD25 + Foxp3 + regulatory T cells facilitate CD4 + T cell clonal anergy induction during the recovery from lymphopenia .
16698419	0	Foxp3	0,5	CD4	17,20	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Foxp3 expressing CD4 + CD25 + and CD8 + CD28 - T regulatory cells in the peripheral blood of patients with lung_cancer and pleural_mesothelioma .
16709816	0	Foxp3	9,14	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T cells and CD4 + CD25-Foxp3 + T cells in aged mice .
16751356	0	Foxp3	34,39	CD4	25,28	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Cutting edge : allogeneic CD4 + CD25 + Foxp3 + T regulatory cells suppress autoimmunity while establishing transplantation tolerance .
16785516	0	Foxp3	98,103	CD4	54,57	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells leads|nmod|induction overexpression|parataxis|leads overexpression|nmod|CD25 CD25|compound|END_ENTITY	G_protein-coupled_receptor_83 overexpression in naive CD4 + CD25 - T cells leads to the induction of Foxp3 + regulatory T cells in vivo .
16879995	0	Foxp3	40,45	CD4	46,49	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Origin and T cell receptor diversity of Foxp3 + CD4 + CD25 + T cells .
16906223	0	Foxp3	34,39	CD4	58,61	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY IFN-gamma|nmod|induction Role|nmod|IFN-gamma Role|nmod|CD25 CD25|compound|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16906223	0	Foxp3	34,39	CD4	80,83	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY IFN-gamma|nmod|induction Role|nmod|IFN-gamma Role|dep|cells cells|nmod|Tregs Tregs|compound|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16914538	0	Foxp3	79,84	CD4	70,73	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A novel mechanism of action for anti-thymocyte globulin : induction of CD4 + CD25 + Foxp3 + regulatory T cells .
16943258	0	Foxp3	65,70	CD4	56,59	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	An MHC-linked locus modulates thymic differentiation of CD4 + CD25 + Foxp3 + regulatory T lymphocytes .
17015695	0	Foxp3	93,98	CD4	84,87	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17056509	0	Foxp3	20,25	CD4	26,29	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Characterization of Foxp3 + CD4 + CD25 + and IL-10-secreting CD4 + CD25 + T cells during cure of colitis .
17056509	2	Foxp3	349,354	CD4	355,358	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Using Foxp3 as a marker of regulatory T cell activity , we now provide a comprehensive analysis of the in vivo distribution of Foxp3 + CD4 + CD25 + cells in wild-type mice , and during cure of experimental colitis .
17079944	0	Foxp3	43,48	CD4	49,52	Foxp3	CD4	50943	920	Gene	Gene	populations|nmod|START_ENTITY roles|nmod|populations +|nsubj|roles +|dobj|cells cells|nummod|END_ENTITY	Clinical roles of increased populations of Foxp3 + CD4 + T cells in peripheral blood from advanced pancreatic_cancer patients .
17082572	0	Foxp3	101,106	CD4	92,95	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cyclophosphamide-induced type-1_diabetes in the NOD mouse is associated with a reduction of CD4 + CD25 + Foxp3 + regulatory T cells .
17114433	0	Foxp3	91,96	CD4	119,122	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Oral tolerance induction with antigen conjugated to cholera_toxin_B_subunit generates both Foxp3 + CD25 + and Foxp3-CD25 - CD4 + regulatory T cells .
17142726	0	Foxp3	24,29	CD4	20,23	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice .
17262084	0	Foxp3	24,29	CD4	30,33	Foxp3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Increase in circulating Foxp3 + CD4 + CD25 -LRB- high -RRB- regulatory T cells in nasopharyngeal_carcinoma patients .
17277105	0	Foxp3	72,77	CD4	48,51	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells CD25|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17296786	0	Foxp3	82,87	CD4	69,72	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	The Wiskott-Aldrich_syndrome protein is required for the function of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
17307871	0	Foxp3	91,96	CD4	51,54	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|dep|cells cells|nmod|CD25 CD25|compound|END_ENTITY	Dendritic cells with TGF-beta1 differentiate naive CD4 + CD25 - T cells into islet-protective Foxp3 + regulatory T cells .
17309822	0	Foxp3	43,48	CD4	66,69	Foxp3	CD4	50943	920	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|CD25 CD25|compound|END_ENTITY	Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4 + CD25 - T lymphocytes .
17311282	0	Foxp3	18,23	CD4	49,52	Foxp3	CD4	50943	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|CD25 CD25|compound|END_ENTITY	The regulation of Foxp3 expression in regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells : multiple pathways on the road .
17316678	0	Foxp3	41,46	CD4	32,35	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The clonal composition of human CD4 + CD25 + Foxp3 + cells determined by a comprehensive DNA-based multiplex PCR for TCRB gene rearrangements .
17339434	0	Foxp3	23,28	CD4	19,22	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Treatment-enhanced CD4 + Foxp3 + glucocorticoid-induced TNF receptor family related high regulatory tumor-infiltrating T cells limit the effectiveness of cytokine-based immunotherapy .
17350019	0	Foxp3	22,27	CD4	11,14	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + CD25 + Foxp3 + T cells expand during experimental Plasmodium infection but do not prevent cerebral_malaria .
17371960	0	Foxp3	58,63	CD4	48,51	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Function of the IL-2R for thymic and peripheral CD4 + CD25 + Foxp3 + T regulatory cells .
17376831	0	Foxp3	38,43	CD4	45,48	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Impaired T cell receptor signaling in Foxp3 + CD4 T cells .
17389235	0	Foxp3	71,76	CD4	60,63	Foxp3	CD4	50943	920	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17428252	0	Foxp3	94,99	CD4	83,86	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Diabetes_in_non-obese diabetic mice is not associated with quantitative changes in CD4 + CD25 + Foxp3 + regulatory T cells .
17453966	0	Foxp3	46,51	CD4	23,26	Foxp3	CD4	50943	920	Gene	Gene	enriches|dobj|START_ENTITY enriches|nmod|CD25 CD25|compound|END_ENTITY	Rapamycin enriches for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD27 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with multiple_sclerosis .
17473687	0	Foxp3	69,74	CD4	19,22	Foxp3	CD4	50943	920	Gene	Gene	cells|dobj|START_ENTITY cells|nsubj|role role|nmod|T T|compound|END_ENTITY	A possible role of CD4 + CD25 + T cells as well as transcription factor Foxp3 in the dysregulation of allergic_rhinitis .
17475646	0	Foxp3	11,16	CD4	18,21	Foxp3	CD4	100348270(Tax:9986)	100009152(Tax:9986)	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Functional Foxp3 + CD4 + CD25 -LRB- Bright + -RRB- `` natural '' regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4 + and CD8 + effector T cells during ocular_herpes_infection .
17475784	0	Foxp3	20,25	CD4	73,76	Foxp3	CD4	50943	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|subsets subsets|compound|END_ENTITY	TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4 + T cell subsets .
17488604	0	Foxp3	13,18	CD4	20,23	Foxp3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	-LSB- Analysis of Foxp3 + CD4 + CD25 + regulatory cells in peripheral blood of patients with SLE -RSB- .
17545218	0	Foxp3	96,101	CD4	149,152	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells promotes|dobj|differentiation promotes|nmod|cells cells|nummod|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17545218	0	Foxp3	96,101	CD4	87,90	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Hodgkin 's reed-sternberg cell line -LRB- KM-H2 -RRB- promotes a bidirectional differentiation of CD4 + CD25 + Foxp3 + T cells and CD4 + cytotoxic T lymphocytes from CD4 + naive T cells .
17615291	0	Foxp3	42,47	CD4	99,102	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD70 + non-Hodgkin_lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4 + CD25 T cells .
17641007	0	Foxp3	99,104	CD4	77,80	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|conversion conversion|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17675505	0	Foxp3	22,27	CD4	105,108	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reveal|nmod|cells reveal|dobj|cells cells|nummod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17675505	0	Foxp3	22,27	CD4	18,21	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17684039	0	Foxp3	78,83	CD4	69,72	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|amod|graft-versus-host_disease graft-versus-host_disease|nmod|+ +|compound|END_ENTITY	Blockade of chronic graft-versus-host_disease by alloantigen-induced CD4 + CD25 + Foxp3 + regulatory T cells in nonlymphopenic hosts .
17687106	0	Foxp3	113,118	CD4	104,107	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4 + CD25 + Foxp3 + regulatory T cells .
17688698	0	Foxp3	68,73	CD4	127,130	Foxp3	CD4	50943	920	Gene	Gene	induction|amod|START_ENTITY induction|nmod|CD25 CD25|nummod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
17699744	0	Foxp3	138,143	CD4	98,101	Foxp3	CD4	50943	920	Gene	Gene	precursors|amod|START_ENTITY specialized|nmod|precursors specialized|nmod|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Dendritic cells are specialized accessory cells along with TGF - for the differentiation of Foxp3 + CD4 + regulatory T cells from peripheral Foxp3 precursors .
17699744	0	Foxp3	91,96	CD4	98,101	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Dendritic cells are specialized accessory cells along with TGF - for the differentiation of Foxp3 + CD4 + regulatory T cells from peripheral Foxp3 precursors .
17728327	0	Foxp3	0,5	CD4	20,23	Foxp3	CD4	50943	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Foxp3 expression in CD4 + T cells of patients with systemic_lupus_erythematosus : a comparative phenotypic analysis .
17785774	0	Foxp3	49,54	CD4	36,39	Foxp3	CD4	50943	920	Gene	Gene	repertoire|compound|START_ENTITY repertoire|compound|END_ENTITY	Cutting edge : size and diversity of CD4 + CD25high Foxp3 + regulatory T cell repertoire in humans : evidence for similarities and partial overlapping with CD4 + CD25 - T cells .
17785792	0	Foxp3	77,82	CD4	53,56	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY suppression|nmod|cells suppression|nmod|transcription transcription|nmod|cells cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17785792	0	Foxp3	77,82	CD4	73,76	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapid suppression of cytokine transcription in human CD4 + CD25 T cells by CD4 + Foxp3 + regulatory T cells : independence of IL-2 consumption , TGF-beta , and various inhibitors of TCR signaling .
17875988	0	Foxp3	31,36	CD4	21,24	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells CD25|acl|+ CD25|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	Foxp3	31,36	CD4	61,64	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nmod|cells cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17911604	0	Foxp3	64,69	CD4	55,58	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
17967941	0	Foxp3	76,81	CD4	129,132	Foxp3	CD4	50943	920	Gene	Gene	inhibition|nmod|START_ENTITY impact|nmod|inhibition +|nsubj|impact +|advcl|cells cells|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17982458	0	Foxp3	9,14	CD4	94,97	Foxp3	CD4	50943	920	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|induce induce|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4 + T cells .
18025186	0	Foxp3	70,75	CD4	66,69	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Keratinocyte_growth_factor induces expansion of murine peripheral CD4 + Foxp3 + regulatory T cells and increases their thymic output .
18029395	0	Foxp3	120,125	CD4	126,129	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Essential roles of TGF-beta in anti-CD3 antibody therapy : reversal of diabetes in nonobese diabetic mice independent of Foxp3 + CD4 + regulatory T cells .
18054287	0	Foxp3	28,33	CD4	12,15	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Decrease Decrease|nmod|CD25 CD25|compound|END_ENTITY	Decrease of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and elevation of CD19 -LRB- + -RRB- BAFF-R -LRB- + -RRB- B cells and soluble ICAM-1 in myasthenia_gravis .
18159952	0	Foxp3	178,183	CD4	169,172	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Repeated 0.5-Gy gamma irradiation attenuates autoimmune_disease in MRL-lpr/lpr mice with suppression of CD3 + CD4-CD8-B220 + T-cell proliferation and with up-regulation of CD4 + CD25 + Foxp3 + regulatory T cells .
18256318	0	Foxp3	108,113	CD4	99,102	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Autologous bone marrow transplantation in autoimmune_arthritis restores immune homeostasis through CD4 + CD25 + Foxp3 + regulatory T cells .
18258482	0	Foxp3	0,5	CD4	6,9	Foxp3	CD4	50943	920	Gene	Gene	immunosuppression|compound|START_ENTITY immunosuppression|compound|END_ENTITY	Foxp3 + CD4 + T cell-mediated immunosuppression involves extracellular nucleotide catabolism .
18279702	0	Foxp3	21,26	CD4	17,20	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GAD-IgG-inducing CD4 + Foxp3 + Treg cells suppressing diabetes are involved in the increasing ratio of CD80 + : CD86 + CELLS in NOD mice .
18283119	0	Foxp3	59,64	CD4	55,58	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The AKT-mTOR axis regulates de novo differentiation of CD4 + Foxp3 + cells .
18304352	0	Foxp3	24,29	CD4	15,18	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	The control of CD4 + CD25 + Foxp3 + regulatory T cell survival .
18320914	0	Foxp3	76,81	CD4	94,97	Foxp3	CD4	50943	920	Gene	Gene	+|amod|START_ENTITY C-260T|nmod|+ interactions|nmod|C-260T interactions|dep|numbers numbers|nummod|+ +|compound|END_ENTITY	Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3 + and Foxp3 - CD4 + lymphocyte numbers and total serum IgE levels in early childhood .
18395858	0	Foxp3	80,85	CD4	86,89	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	Critical role of IL-2 and TGF-beta in generation , function and stabilization of Foxp3 + CD4 + Treg .
18412171	0	Foxp3	56,61	CD4	106,109	Foxp3	CD4	50943	920	Gene	Gene	isoforms|compound|START_ENTITY either|nmod|isoforms overexpression|nmod|either induce|nsubj|overexpression induce|nmod|cells cells|amod|END_ENTITY	Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- cells .
18431238	0	Foxp3	91,96	CD4	82,85	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Depleting anti-CD4 monoclonal antibody -LRB- GK1 .5 -RRB- treatment : influence on regulatory CD4 + CD25 + Foxp3 + T cells in mice .
18453622	0	Foxp3	88,93	CD4	79,82	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	dysfunction|compound|START_ENTITY dysfunction|compound|END_ENTITY	Development of inflammatory_bowel_disease in Long-Evans Cinnamon rats based on CD4 + CD25 + Foxp3 + regulatory T cell dysfunction .
18462346	0	Foxp3	69,74	CD4	58,61	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
18477692	0	Foxp3	75,80	CD4	66,69	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18477692	0	Foxp3	95,100	CD4	66,69	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|amod|IL-1 IL-1|nmod|expansion/differentiation expansion/differentiation|nmod|+ +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18480441	0	Foxp3	47,52	CD4	36,39	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro-generated antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells control the severity of herpes simplex virus-induced ocular_immunoinflammatory_lesions .
18490709	0	Foxp3	14,19	CD4	20,23	Foxp3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18493984	0	Foxp3	49,54	CD4	36,39	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|suppression suppression|nmod|CD25 CD25|compound|END_ENTITY	IL-2 induces in vivo suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18503888	0	Foxp3	80,85	CD4	67,70	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|tolerance tolerance|nmod|CD25 CD25|compound|END_ENTITY	Induction of transplantation tolerance by allogeneic donor-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18510697	0	Foxp3	0,5	CD4	40,43	Foxp3	CD4	50943	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Foxp3 expression on normal and leukemic CD4 + CD25 + T cells implicated in human T-cell_leukemia_virus_type-1 is inconsistent with Treg cells .
18566388	0	Foxp3	34,39	CD4	25,28	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18599457	0	Foxp3	73,78	CD4	79,82	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Programmed_death_1_ligand signaling regulates the generation of adaptive Foxp3 + CD4 + regulatory T cells .
18641303	0	Foxp3	104,109	CD4	45,48	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY repressing|dobj|expression regulates|advcl|repressing regulates|dobj|differentiation differentiation|nummod|END_ENTITY	IFN regulatory factor-1 negatively regulates CD4 + CD25 + regulatory T cell differentiation by repressing Foxp3 expression .
18658093	0	Foxp3	27,32	CD4	18,21	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vitro expanded CD4 + CD25 + Foxp3 + regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation .
18676178	0	Foxp3	29,34	CD4	37,40	Foxp3	CD4	50943	920	Gene	Gene	CD25|amod|START_ENTITY CD25|compound|END_ENTITY	Natural and TGF-beta-induced Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells are not mirror images of each other .
18784738	0	Foxp3	201,206	CD4	197,200	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Lenalidomide alone or in combination with dexamethasone is highly effective in patients with relapsed multiple_myeloma following allogeneic stem cell transplantation and increases the frequency of CD4 + Foxp3 + T cells .
18792402	0	Foxp3	34,39	CD4	25,28	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Resting B cells expand a CD4 + CD25 + Foxp3 + Treg population via TGF-beta3 .
18832523	0	Foxp3	4,9	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expansion|compound|START_ENTITY expansion|compound|END_ENTITY	CD4 + Foxp3 + regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells .
18832672	0	Foxp3	95,100	CD4	84,87	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Cutting edge : CD47 controls the in vivo proliferation and homeostasis of peripheral CD4 + CD25 + Foxp3 + regulatory T cells that express CD103 .
18924611	0	Foxp3	20,25	CD4	16,19	Foxp3	CD4	50943	920	Gene	Gene	accumulation|compound|START_ENTITY accumulation|compound|END_ENTITY	The kinetics of CD4 + Foxp3 + T cell accumulation during a human cutaneous antigen-specific memory response in vivo .
18930767	0	Foxp3	25,30	CD4	21,24	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	In vivo expansion of CD4 + Foxp3 + regulatory T cells mediated by GITR molecules .
18941219	0	Foxp3	51,56	CD4	46,49	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Impact of protective IL-2 allelic variants on CD4 + Foxp3 + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice .
18981109	0	Foxp3	17,22	CD4	6,9	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + CD25 + Foxp3 + regulatory T cells do not constitutively express IL-35 .
18981295	0	Foxp3	85,90	CD4	76,79	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4 + CD25 + Foxp3 + T regulatory cells in mycobacterial_infection .
19003876	0	Foxp3	48,53	CD4	55,58	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Local accumulation and activation of regulatory Foxp3 + CD4 T -LRB- R -RRB- cells accompanies the appearance of activated CD8 T cells in the liver .
19006694	0	Foxp3	23,28	CD4	79,82	Foxp3	CD4	50943	920	Gene	Gene	induction|amod|START_ENTITY enhances|dobj|induction enhances|advcl|relieving relieving|nmod|Cells Cells|compound|END_ENTITY	Retinoic_acid enhances Foxp3 induction indirectly by relieving inhibition from CD4 + CD44hi Cells .
19019089	0	Foxp3	16,21	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|compound|CD25 CD25|compound|END_ENTITY	CD4 + CD25 -LRB- high -RRB- Foxp3 + regulatory T cells downregulate human Vdelta2 + T-lymphocyte function triggered by anti-CD3 or phosphoantigen .
19034003	0	Foxp3	51,56	CD4	25,28	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	corrected|dobj|START_ENTITY -LSB-|acl|corrected -LSB-|compound|END_ENTITY	Pancreatic islets induce CD4 -LRB- + -RRB- -LSB- corrected -RSB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- -LSB- corrected -RSB- T-cell regulated tolerance to HY-mismatched skin grafts .
19077104	0	Foxp3	14,19	CD4	20,23	Foxp3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Expression of Foxp3 + CD4 + CD25 + regulatory T cells and Th1/Th2 , Tc1/Tc2 profiles in the peripheral blood of patients with condyloma acuminatum .
19089814	0	Foxp3	34,39	CD4	29,32	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Early recruitment of natural CD4 + Foxp3 + Treg cells by infective larvae determines the outcome of filarial_infection .
19146957	0	Foxp3	60,65	CD4	51,54	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	The significantly enhanced frequency of functional CD4 + CD25 + Foxp3 + T regulatory cells in therapeutic dose aspirin-treated mice .
19153062	0	Foxp3	53,58	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	express|dobj|START_ENTITY cells|dep|express CD127|dobj|cells CD127|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- low / - -RRB- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric_cancers progression .
19155519	0	Foxp3	49,54	CD4	38,41	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY analysis|dep|cells analysis|nmod|CD25 CD25|compound|END_ENTITY	Phenotypic and functional analysis of CD4 + CD25 - Foxp3 + T cells in patients with systemic_lupus_erythematosus .
19214972	0	Foxp3	34,39	CD4	30,33	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Control of type_1_diabetes by CD4 + Foxp3 + regulatory T cells : lessons from mouse models and implications for human disease .
19221040	0	Foxp3	90,95	CD4	81,84	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4 + CD25 + Foxp3 + T regulatory cells that protects against graft-versus-host_disease .
19229109	0	Foxp3	36,41	CD4	27,30	Foxp3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|nummod|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
19234174	0	Foxp3	127,132	CD4	118,121	Foxp3	CD4	50943	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human dendritic cells produce TGF-beta_1 under the influence of lung_carcinoma cells and prime the differentiation of CD4 + CD25 + Foxp3 + regulatory T cells .
19234199	0	Foxp3	52,57	CD4	59,62	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	priming|nmod|START_ENTITY priming|dep|cells cells|nummod|END_ENTITY	Selective priming and expansion of antigen-specific Foxp3 - CD4 + T cells during Listeria_monocytogenes infection .
19283777	0	Foxp3	76,81	CD4	125,128	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY tolerance|dep|loss tolerance|dep|cells cells|nmod|anergy anergy|compound|END_ENTITY	T-cell tolerance induced by repeated antigen stimulation : selective loss of Foxp3 - conventional CD4 T cells and induction of CD4 T-cell anergy .
19283777	0	Foxp3	76,81	CD4	96,99	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY tolerance|dep|loss tolerance|dep|cells cells|compound|END_ENTITY	T-cell tolerance induced by repeated antigen stimulation : selective loss of Foxp3 - conventional CD4 T cells and induction of CD4 T-cell anergy .
19342638	0	Foxp3	77,82	CD4	54,57	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nmod|+ CD25|dep|cells CD25|compound|END_ENTITY	Activin a promotes the TGF-beta-induced conversion of CD4 + CD25 - T cells into Foxp3 + induced regulatory T cells .
19364517	0	Foxp3	19,24	CD4	10,13	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased CD4 + CD25 + Foxp3 + T cells in peripheral blood of celiac_disease patients : correlation with dietary treatment .
19380824	0	Foxp3	27,32	CD4	57,60	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|cells cells|compound|END_ENTITY	Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1 .
19381159	0	Foxp3	45,50	CD4	52,55	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	SOCS1 negatively regulates the production of Foxp3 + CD4 + T cells in the thymus .
19448155	0	Foxp3	26,31	CD4	17,20	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
19452318	0	Foxp3	47,52	CD4	35,38	Foxp3	CD4	50943	920	Gene	Gene	T-cells|compound|START_ENTITY +|dobj|T-cells +|nsubj|formation formation|nmod|END_ENTITY	Enhanced formation and survival of CD4 + CD25hi Foxp3 + T-cells in chronic_lymphocytic_leukemia .
19494258	0	Foxp3	85,90	CD4	81,84	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	mechanism|compound|START_ENTITY mechanism|compound|END_ENTITY	Keratinocyte_growth_factor improves allogeneic bone marrow engraftment through a CD4 + Foxp3 + regulatory T cell-dependent mechanism .
19535644	0	Foxp3	127,132	CD4	117,120	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4 + CD25 + Foxp3 + T regulatory cells .
19609976	0	Foxp3	53,58	CD4	43,46	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|numbers numbers|nmod|CD25 CD25|compound|END_ENTITY	Increased numbers of thymic and peripheral CD4 + CD25 + Foxp3 + cells in the absence of CD5 signaling .
19616200	0	Foxp3	79,84	CD4	11,14	Foxp3	CD4	50943	920	Gene	Gene	granzyme_B|appos|START_ENTITY expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19620303	0	Foxp3	20,25	CD4	45,48	Foxp3	CD4	50943	920	Gene	Gene	+|amod|START_ENTITY development|nmod|+ thymocytes|nsubj|development thymocytes|nmod|subset subset|compound|END_ENTITY	Rare development of Foxp3 + thymocytes in the CD4 + CD8 + subset .
19625166	0	Foxp3	198,203	CD4	189,192	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental_allergic_encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4 + CD25 + Foxp3 + regulatory T cells .
19665867	0	Foxp3	101,106	CD4	92,95	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4 + CD25 + Foxp3 + regulatory T cell population .
19706340	0	Foxp3	70,75	CD4	61,64	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Naloxone can improve the anti-tumor immunity by reducing the CD4 + CD25 + Foxp3 + regulatory T cells in BALB/c mice .
19709757	0	Foxp3	32,37	CD4	23,26	Foxp3	CD4	50943	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Induction of inducible CD4 + CD25 + Foxp3 + regulatory T lymphocytes by porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- .
19740328	0	Foxp3	148,153	CD4	137,140	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Distinct regulatory roles of transforming growth factor-beta and interleukin-4 in the development and maintenance of natural and induced CD4 + CD25 + Foxp3 + regulatory T cells .
19740339	0	Foxp3	71,76	CD4	66,69	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	IFN-gamma production in response to Tax 161-233 , and frequency of CD4 + Foxp3 + and Lin HLA-DRhigh CD123 + cells , discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population .
19770521	0	Foxp3	9,14	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Tregs resolve experimental lung_injury in mice and are present in humans with acute_lung_injury .
19841877	0	Foxp3	13,18	CD4	54,57	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	demethylation|amod|START_ENTITY Induction|nmod|demethylation increases|nsubj|Induction increases|dobj|cells cells|compound|END_ENTITY	Induction of Foxp3 demethylation increases regulatory CD4 + CD25 + T cells and prevents the occurrence of diabetes in mice .
19845018	0	Foxp3	18,23	CD4	98,101	Foxp3	CD4	50943	920	Gene	Gene	antibody|amod|START_ENTITY importance|nmod|antibody importance|acl|identifying identifying|dobj|Foxp3 Foxp3|compound|END_ENTITY	The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4 + CD25 + Foxp3 + regulatory T cells .
19852824	0	Foxp3	43,48	CD4	88,91	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4 + Treg cells .
19915051	0	Foxp3	39,44	CD4	66,69	Foxp3	CD4	50943	920	Gene	Gene	+|amod|START_ENTITY ratio|nmod|+ increase|nmod|ratio END_ENTITY|nsubj|increase	Systemic increase in the ratio between Foxp3 + and IL-17-producing CD4 + T cells in healthy pregnancy but not in preeclampsia .
19949075	0	Foxp3	15,20	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T regulatory cells with limited TCR diversity in control of autoimmunity .
19953886	0	Foxp3	58,63	CD4	10,13	Foxp3	CD4	50943	920	Gene	Gene	mRNA|amod|START_ENTITY +|nmod|mRNA +|nsubj|Study Study|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Study of CD4 + CD25 + regulatory T cells and expression of Foxp3 mRNA in bronchiolitis and glucocorticoid regulation -RSB- .
19961805	0	Foxp3	38,43	CD4	19,22	Foxp3	CD4	50943	920	Gene	Gene	comparison|dep|START_ENTITY comparison|nmod|END_ENTITY	-LSB- The comparison of CD4 -LRB- + -RRB- ; CD25 -LRB- high -RRB- ; Foxp3 -LRB- + -RRB- ; regulatory T cells between neonatal cord blood and adult peripheral blood . -RSB- .
19995950	0	Foxp3	48,53	CD4	55,58	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	c-Rel is required for the development of thymic Foxp3 + CD4 regulatory T cells .
20006940	0	Foxp3	40,45	CD4	27,30	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|CD25 CD25|compound|END_ENTITY	Effect of in vitroexpanded CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cell therapy combined with lymphodepletion in murine skin allotransplantation .
20049877	0	Foxp3	38,43	CD4	58,61	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	c-Rel is crucial for the induction of Foxp3 -LRB- + -RRB- regulatory CD4 -LRB- + -RRB- T cells but not T -LRB- H -RRB- 17 cells .
20059576	0	Foxp3	108,113	CD4	101,104	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY suppress|nsubj|cells END_ENTITY|acl:relcl|suppress	Prevention and treatment of experimental_autoimmune_encephalomyelitis with clonotypic CDR3 peptides : CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T-regulatory cells suppress interleukin-2-dependent expansion of myelin_basic_protein-specific T cells .
20080669	0	Foxp3	49,54	CD4	45,48	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Generation of regulatory dendritic cells and CD4 + Foxp3 + T cells by probiotics administration suppresses immune_disorders .
20081380	0	Foxp3	70,75	CD4	59,62	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20142839	0	Foxp3	0,5	CD4	56,59	Foxp3	CD4	50943	12504(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY precedes|nsubj|induction precedes|dobj|stage stage|compound|END_ENTITY	Foxp3 induction in human and murine thymus precedes the CD4 + CD8 + stage but requires early T-cell receptor expression .
20357481	0	Foxp3	22,27	CD4	13,16	Foxp3	CD4	50943	920	Gene	Gene	IL-10|compound|START_ENTITY IL-10|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + IL-10 + T cells in HDM-allergic asthmatic children with or without SIT .
20378024	0	Foxp3	9,14	CD4	0,3	Foxp3	CD4	506053(Tax:9913)	407098(Tax:9913)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T regulatory cells are not involved in oral desensitization .
20382706	0	Foxp3	23,28	CD4	46,49	Foxp3	CD4	50943	920	Gene	Gene	IFN-gamma|dep|START_ENTITY END_ENTITY|nsubj|IFN-gamma	Antigen-specific CD25 - Foxp3 - IFN-gamma -LRB- high -RRB- CD4 + T cells restrain the development of experimental_allergic_encephalomyelitis by suppressing Th17 .
20382886	0	Foxp3	65,70	CD4	54,57	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20394727	0	Foxp3	129,134	CD4	120,123	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Uptake of donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light by recipient dendritic cells induces CD4 + CD25 + Foxp3 + regulatory T cells and down-regulates cardiac allograft rejection .
20463648	0	Foxp3	105,110	CD4	101,104	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intravenous immunoglobulins promote skin allograft acceptance by triggering functional activation of CD4 + Foxp3 + T cells .
20477811	0	Foxp3	16,21	CD4	24,27	Foxp3	CD4	50943	920	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|cells cells|amod|END_ENTITY	Distribution of Foxp3 - , CD4 - and CD8-positive lymphocytic cells in benign and malignant prostate tissue .
20497692	0	Foxp3	4,9	CD4	69,72	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|converted converted|nmod|CD25 CD25|compound|END_ENTITY	CD4 + Foxp3 + regulatory T cells converted by rapamycin from peripheral CD4 + CD25 -LRB- - -RRB- naive T cells display more potent regulatory ability in vitro .
20515837	0	Foxp3	15,20	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and hematologic_malignancies .
20522244	0	Foxp3	0,5	CD4	30,33	Foxp3	CD4	50943	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|suppression suppression|compound|END_ENTITY	Foxp3 regulates human natural CD4 + CD25 + regulatory T-cell-mediated suppression of xenogeneic response .
20546740	0	Foxp3	30,35	CD4	26,29	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD39/ENTPD1 expression by CD4 + Foxp3 + regulatory T cells promotes hepatic metastatic_tumor growth in mice .
20591118	0	Foxp3	81,86	CD4	88,91	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Human visceral_leishmaniasis is not associated with expansion or accumulation of Foxp3 + CD4 cells in blood or spleen .
20639494	0	Foxp3	0,5	CD4	7,10	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Foxp3 + CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory_syncytial_virus_infection .
20688398	0	Foxp3	20,25	CD4	51,54	Foxp3	CD4	50943	920	Gene	Gene	variants|amod|START_ENTITY variants|nmod|+ +|compound|END_ENTITY	Characterisation of Foxp3 splice variants in human CD4 + and CD8 + T cells -- identification of Foxp3 / \ 7 in human regulatory T cells .
20688398	0	Foxp3	92,97	CD4	51,54	Foxp3	CD4	50943	920	Gene	Gene	identification|nmod|START_ENTITY Characterisation|dep|identification Characterisation|nmod|variants variants|nmod|+ +|compound|END_ENTITY	Characterisation of Foxp3 splice variants in human CD4 + and CD8 + T cells -- identification of Foxp3 / \ 7 in human regulatory T cells .
20713627	0	Foxp3	11,16	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells , dendritic cells , and circulating cytokines in uncomplicated malaria : do different parasite species elicit similar host responses ?
20729906	0	Foxp3	24,29	CD4	19,22	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + but not CD4 + Foxp3 + T cells as a regulatory subset in primary_biliary_cirrhosis .
20800824	0	Foxp3	49,54	CD4	43,46	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|selection selection|nmod|END_ENTITY	Thymic selection and lineage commitment of CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T lymphocytes .
20821727	0	Foxp3	96,101	CD4	75,78	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|amod|inflammation inflammation|nmod|CD25 CD25|compound|END_ENTITY	Control of Schistosoma_mansoni egg-induced inflammation by IL-4-responsive CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- CD103 -LRB- + -RRB- Foxp3 -LRB- - -RRB- cells is IL-10-dependent .
20832552	0	Foxp3	76,81	CD4	59,62	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|amod|Influence Influence|nmod|drugs drugs|nmod|development development|nmod|CD25 CD25|compound|END_ENTITY	Influence of immunosuppressive drugs on the development of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells in liver transplant recipients .
20848841	0	Foxp3	93,98	CD4	28,31	Foxp3	CD4	50943	920	Gene	Gene	expression|nmod|START_ENTITY +|nmod|expression +|nsubj|Studies Studies|nmod|level level|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Studies about the level of CD4 + CD25 + regulatory T cells and relation between expression of Foxp3 and CD127 in peripheral blood of chronic HBV_infection -RSB- .
20871628	0	Foxp3	107,112	CD4	96,99	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	2-Gy whole-body irradiation significantly alters the balance of CD4 + CD25 - T effector cells and CD4 + CD25 + Foxp3 + T regulatory cells in mice .
21057085	0	Foxp3	128,133	CD4	94,97	Foxp3	CD4	50943	920	Gene	Gene	cells|nmod|START_ENTITY +|nsubj|cells agonists|parataxis|+ agonists|dep|convert convert|dobj|CD25 CD25|compound|END_ENTITY	Peroxisome proliferator-activated receptor a and y agonists together with TGF-b convert human CD4 + CD25 - T cells into functional Foxp3 + regulatory T cells .
21072213	0	Foxp3	9,14	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	depletion|compound|START_ENTITY depletion|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells depletion may attenuate the development of silica-induced lung_fibrosis in mice .
21124798	0	Foxp3	74,79	CD4	47,50	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY cells|nmod|induction cells|compound|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
21255144	0	Foxp3	17,22	CD4	12,15	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Skin-homing CD4 + Foxp3 + T cells exert Th2-like function after staphylococcal superantigen stimulation in atopic_dermatitis patients .
21312192	0	Foxp3	5,10	CD4	79,82	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY share|nsubj|cells share|nmod|cells cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21312192	0	Foxp3	84,89	CD4	79,82	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21314851	0	Foxp3	31,36	CD4	16,19	Foxp3	CD4	50943	920	Gene	Gene	T|nsubj|START_ENTITY T|dep|circulating circulating|dobj|CD25 CD25|compound|END_ENTITY	Low circulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- _ Foxp3 -LRB- + -RRB- T regulatory cell levels predict miscarriage risk in newly pregnant women with a history of failure .
21376048	0	Foxp3	64,69	CD4	50,53	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human colonic myofibroblasts promote expansion of CD4 + CD25high Foxp3 + regulatory T cells .
21389253	0	Foxp3	54,59	CD4	50,53	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 contributes to maintaining a balance between CD4 + Foxp3 + regulatory T cells and effector CD4 + T cells required for immune control of blood-stage malaria_infection .
21395511	0	Foxp3	38,43	CD4	56,59	Foxp3	CD4	50943	920	Gene	Gene	+|amod|START_ENTITY induction|nmod|+ activin_A|nmod|induction Role|nmod|activin_A Role|dep|+ +|compound|END_ENTITY	Role of activin_A in the induction of Foxp3 + and Foxp3 - CD4 + regulatory T cells .
21402894	0	Foxp3	46,51	CD4	64,67	Foxp3	CD4	50943	920	Gene	Gene	induction|nmod|START_ENTITY +|nsubj|induction +|dobj|cells cells|compound|END_ENTITY	Cutting edge : De novo induction of functional Foxp3 + regulatory CD4 T cells in response to tissue-restricted self antigen .
21447271	0	Foxp3	10,15	CD4	1,4	Foxp3	CD4	50943	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	-LSB- CD4 + CD25 + Foxp3 + T lymphocytes : naturally occuring regulatory T cells -RSB- .
21469093	0	Foxp3	85,90	CD4	12,15	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY triggers|nmod|cells triggers|nsubj|activation activation|compound|END_ENTITY	Sub-optimal CD4 + T-cell activation triggers autonomous TGF-b-dependent conversion to Foxp3 + regulatory T cells .
21469094	0	Foxp3	122,127	CD4	111,114	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Steady state migratory RelB + langerin + dermal dendritic cells mediate peripheral induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells .
21472340	0	Foxp3	67,72	CD4	87,90	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	Foxp3	96,101	CD4	63,66	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells Foxp3|dep|cells Foxp3|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	Foxp3	96,101	CD4	87,90	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21511184	0	Foxp3	65,70	CD4	96,99	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Th17 cells express interleukin-10_receptor_and are controlled by Foxp3 and Foxp3 + regulatory CD4 + T cells in an interleukin-10-dependent manner .
21519344	0	Foxp3	26,31	CD4	13,16	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Induction|nmod|cells Induction|nmod|CD25 CD25|compound|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21519344	0	Foxp3	26,31	CD4	78,81	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|dep|stimulation stimulation|nmod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21528082	0	Foxp3	38,43	CD4	34,37	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Gastric_cancer cells induce human CD4 + Foxp3 + regulatory T cells through the production of TGF-b1 .
21558138	0	Foxp3	32,37	CD4	21,24	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
21600126	0	Foxp3	23,28	CD4	29,32	Foxp3	CD4	50943	920	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	-LSB- Study of fas-mediated Foxp3 + CD4 + CD25 + Treg cell apoptosis in patients with systemic_lupus_erythematosus -RSB- .
21604971	0	Foxp3	69,74	CD4	64,67	Foxp3	CD4	50943	920	Gene	Gene	suppression|compound|START_ENTITY suppression|compound|END_ENTITY	Transfer of cell membrane components via trogocytosis occurs in CD4 + Foxp3 + CD25 + regulatory T-cell contact-dependent suppression .
21604973	0	Foxp3	34,39	CD4	25,28	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Decreased frequencies of CD4 + CD25 + Foxp3 + cells and the potent CD103 + subset in peripheral lymph_nodes correlate with autoimmune_disease predisposition in some strains of mice .
21623989	0	Foxp3	42,47	CD4	49,52	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	conversion|nmod|START_ENTITY conversion|dep|cells cells|nummod|END_ENTITY	FTY720-induced conversion of conventional Foxp3 - CD4 + T cells to Foxp3 + regulatory T cells in NOD mice .
21623989	0	Foxp3	65,70	CD4	49,52	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|nummod|END_ENTITY	FTY720-induced conversion of conventional Foxp3 - CD4 + T cells to Foxp3 + regulatory T cells in NOD mice .
21640985	0	Foxp3	8,13	CD4	3,6	Foxp3	CD4	50943	920	Gene	Gene	correlate|compound|START_ENTITY correlate|compound|END_ENTITY	Do CD4 + Foxp3 + Treg cells correlate with transplant outcomes : a systematic review on recipients of solid organ transplantation .
21677778	0	Foxp3	123,128	CD4	26,29	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY vivo|nmod|expression helper|nmod|vivo differentiating|xcomp|helper cells|acl|differentiating cells|compound|END_ENTITY	Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression .
21708889	0	Foxp3	37,42	CD4	24,27	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Increase in circulating CD4 CD25 Foxp3 T cells in patients with Philadelphia-negative chronic_myeloproliferative_neoplasms during treatment with IFN-a .
21710488	0	Foxp3	41,46	CD4	71,74	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	The S. _ mansoni glycoprotein -1 induces Foxp3 expression in NOD mouse CD4 T cells .
21724410	0	Foxp3	65,70	CD4	71,74	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tissular T -LRB- regs -RRB- : a unique population of adipose-tissue-resident Foxp3 + CD4 + T cells that impacts organismal metabolism .
21726337	0	Foxp3	9,14	CD4	26,29	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|acl|expressing expressing|dobj|+ +|compound|END_ENTITY	Maternal Foxp3 expressing CD4 + CD25 + and CD4 + CD25 - regulatory T-cell populations are enriched in human early normal pregnancy decidua : a phenotypic study of paired decidual and peripheral blood samples .
21734238	0	Foxp3	124,129	CD4	115,118	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Rapamycin and IL-2 reduce lethal acute_graft-versus-host_disease associated with increased expansion of donor type CD4 + CD25 + Foxp3 + regulatory T cells .
21785365	0	Foxp3	13,18	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 CD25 Foxp3 regulatory T cells suppress cardiac_fibrosis in the hypertensive heart .
21792941	0	Foxp3	47,52	CD4	71,74	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY cells|appos|+ ratio|nmod|cells ratio|parataxis|factor factor|nsubj|cells cells|appos|+ +|compound|END_ENTITY	The ratio of intra-tumoral regulatory T cells -LRB- Foxp3 + -RRB- / helper T cells -LRB- CD4 + -RRB- is a prognostic factor and associated with recurrence pattern in gastric_cardia_cancer .
21843083	0	Foxp3	41,46	CD4	32,35	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Neem leaf glycoprotein inhibits CD4 + CD25 + Foxp3 + Tregs to restrict murine tumor growth .
21873213	0	Foxp3	43,48	CD4	107,110	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|amod|START_ENTITY selection|nmod|+ impact|nmod|selection impact|dep|subsets subsets|nmod|T T|compound|END_ENTITY	Quantitative impact of thymic selection on Foxp3 + and Foxp3 - subsets of self-peptide/MHC class II-specific CD4 + T cells .
21873239	0	Foxp3	13,18	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	CD4 CD25 Foxp3 regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion .
21875661	0	Foxp3	89,94	CD4	76,79	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	enhancement|dep|START_ENTITY enhancement|nmod|CD25 CD25|compound|END_ENTITY	Cortex Mori Radicis extract exerts antiasthmatic effects via enhancement of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and inhibition of Th2 cytokines in a mouse asthma model .
21916916	0	Foxp3	21,26	CD4	41,44	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Transient attenuated Foxp3 expression on CD4 T cells treated with 7D4 mAb contributes to the control of parasite burden in DBA/2 mice infected with lethal Plasmodium_chabaudi_chabaudi AS .
21983870	0	Foxp3	35,40	CD4	26,29	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Alterations of peripheral CD4 + CD25 + Foxp3 + T regulatory cells in mice with STZ-induced diabetes .
22005288	0	Foxp3	24,29	CD4	13,16	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
22034573	0	Foxp3	30,35	CD4	21,24	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	Thioperamide induces CD4 CD25 Foxp3 regulatory T lymphocytes in the lung mucosa of allergic mice through its action on dendritic cells .
22066012	0	Foxp3	68,73	CD4	75,78	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	c-Rel controls multiple discrete steps in the thymic development of Foxp3 + CD4 regulatory T cells .
22079196	0	Foxp3	0,5	CD4	36,39	Foxp3	CD4	50943	920	Gene	Gene	critical|nsubj|START_ENTITY critical|nmod|cells cells|nummod|END_ENTITY	Foxp3 is critical for human natural CD4 + CD25 + regulatory T cells to suppress alloimmune response .
22110383	0	Foxp3	98,103	CD4	92,95	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Regulating the adaptive immune response to blood-stage_malaria : role of dendritic cells and CD4 Foxp3 regulatory T cells .
22164498	0	Foxp3	74,79	CD4	63,66	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Effects of excreted/secreted antigens of Toxoplasma_gondii on CD4 + CD25 + Foxp3 + T cells and NK cells of melanoma-bearing mice -RSB- .
22192331	0	Foxp3	28,33	CD4	13,16	Foxp3	CD4	50943	920	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	Responses of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- and IL-10-secreting type I T regulatory cells to cluster-specific_immunotherapy for allergic_rhinitis in children .
22215739	0	Foxp3	82,87	CD4	77,80	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY cell|compound|END_ENTITY	Failure to recruit anti-inflammatory CD103 + dendritic cells and a diminished CD4 + Foxp3 + regulatory T cell pool in mice that display excessive_lung_inflammation and increased susceptibility to Mycobacterium_tuberculosis .
22220406	0	Foxp3	45,50	CD4	36,39	Foxp3	CD4	50943	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Augmentation of regulatory T cells -LRB- CD4 + CD25 + Foxp3 + -RRB- correlates with tumor stage in patients with colorectal_cancer .
22222264	0	Foxp3	57,62	CD4	39,42	Foxp3	CD4	50943	920	Gene	Gene	Adalimumab|dep|START_ENTITY Adalimumab|dobj|END_ENTITY	Adalimumab specifically induces CD3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- CD127 -LRB- - -RRB- T-regulatory cells and decreases vascular endothelial growth factor plasma levels in refractory immuno-mediated uveitis : a non-randomized pilot intervention study .
22270834	0	Foxp3	121,126	CD4	57,60	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|naive naive|dep|END_ENTITY	Dendritic cells with TGF-b1 and IL-2 differentiate naive CD4 + T cells into alloantigen-specific and allograft protective Foxp3 + regulatory T cells .
22322668	0	Foxp3	83,88	CD4	79,82	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|amod|functional functional|dep|END_ENTITY	Immune suppression in premalignant respiratory_papillomas : enriched functional CD4 + Foxp3 + regulatory T cells and PD-1 / PD-L1 / L2 expression .
22406048	0	Foxp3	82,87	CD4	111,114	Foxp3	CD4	50943	920	Gene	Gene	increasing|iobj|START_ENTITY increasing|dobj|cells cells|amod|demethylation demethylation|nmod|T T|compound|END_ENTITY	Total_glucosides_of_paeony induces regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells by increasing Foxp3 demethylation in lupus CD4 -LRB- + -RRB- T cells .
22406048	0	Foxp3	82,87	CD4	46,49	Foxp3	CD4	50943	920	Gene	Gene	increasing|iobj|START_ENTITY cells|acl|increasing CD25|dep|cells induces|nsubj|CD25 induces|dobj|END_ENTITY	Total_glucosides_of_paeony induces regulatory CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells by increasing Foxp3 demethylation in lupus CD4 -LRB- + -RRB- T cells .
22426168	0	Foxp3	6,11	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 Foxp3 Treg and its ICOS subsets in patients with myocardial_infarction .
22466569	0	Foxp3	59,64	CD4	46,49	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	Lactobacillus_acidophilus_strain L-92 induces CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and suppresses allergic contact_dermatitis .
22539290	0	Foxp3	21,26	CD4	14,17	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Activation of CD4 Foxp3 regulatory T cells proceeds normally in the absence of B cells during EAE .
22564624	0	Foxp3	88,93	CD4	73,76	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|cytotoxicity cytotoxicity|nmod|cell cell|nmod|CD25 CD25|compound|END_ENTITY	Inhibition of allogenic T-cell cytotoxicity by hepatic stellate cell via CD4 CD25 Foxp3 regulatory T cells in vitro .
22587982	0	Foxp3	141,146	CD4	73,76	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Effects Effects|nmod|Decoction Decoction|nmod|ratio ratio|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Effects of Chinese herbal medicine Feiyanning Decoction on the ratio of CD4 + CD25 + regulatory T cells and expression of transcription factor Foxp3 in mice bearing Lewis_lung_carcinoma -RSB- .
22609353	0	Foxp3	73,78	CD4	60,63	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22681667	0	Foxp3	105,110	CD4	100,103	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Donor-specific CD8 + Foxp3 + T cells protect skin allografts and facilitate induction of conventional CD4 + Foxp3 + regulatory T cells .
22718263	0	Foxp3	154,159	CD4	150,153	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic_airway_disease are CD5 + , express TGF-b , and co-localize with CD4 + Foxp3 + T cells .
22749982	0	Foxp3	54,59	CD4	61,64	Foxp3	CD4	50943	920	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|CD25 CD25|compound|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22769982	0	Foxp3	118,123	CD4	105,108	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY increasing|iobj|+ increasing|iobj|CD25 CD25|compound|END_ENTITY	Pretreatment of rapamycin before allogenic corneal transplant promotes graft survival through increasing CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
22773728	0	Foxp3	15,20	CD4	11,14	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY induce|nsubj|cells +|ccomp|induce +|nsubj|END_ENTITY	Polyclonal CD4 + Foxp3 + Treg cells induce TGFb-dependent tolerogenic dendritic cells that suppress the murine lupus-like_syndrome .
22776176	0	Foxp3	132,137	CD4	93,96	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|compound|END_ENTITY	Histone deacetylase inhibitors promote mice corneal allograft survival through alteration of CD4 + effector T cells and induction of Foxp3 + regulatory T cells .
22817851	0	Foxp3	18,23	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- cells increased in the peritoneal fluid of patients with endometriosis .
22873180	0	Foxp3	122,127	CD4	113,116	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fermented fish oil suppresses T helper 1/2 cell response in a mouse model of atopic_dermatitis via generation of CD4 + CD25 + Foxp3 + T cells .
22884147	0	Foxp3	30,35	CD4	17,20	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|changes changes|nmod|CD25 CD25|compound|END_ENTITY	Early changes of CD4 CD25 Foxp3 regulatory T cells and Th1/Th2 , Tc1/Tc2 profiles in the peripheral blood of rats with controlled hemorrhagic_shock and no fluid resuscitation .
22891805	0	Foxp3	116,121	CD4	107,110	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4 -LRB- + -RRB- / CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- cells .
22891805	0	Foxp3	116,121	CD4	99,102	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Protection conferred by heterologous vaccination against tuberculosis is dependent on the ratio of CD4 -LRB- + -RRB- / CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- cells .
22921804	0	Foxp3	37,42	CD4	24,27	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY CD25|nmod|cells CD25|compound|END_ENTITY	Increased proportion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells during early-stage sepsis in ICU patients .
22928057	0	Foxp3	22,27	CD4	15,18	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of CD4 Foxp3 regulatory T cells in persistence of Leishmania_donovani in the liver of alymphoplastic aly/aly mice .
23017670	0	Foxp3	11,16	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY CD25|acl:relcl|Treg CD25|compound|END_ENTITY	CD4 + CD25 + Foxp3 + IFNy + CD178 + human induced Treg -LRB- iTreg -RRB- contribute to suppression of alloresponses by apoptosis of responder cells .
23041608	0	Foxp3	128,133	CD4	119,122	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Activation of the aryl_hydrocarbon_receptor reduces the number of precursor and effector T cells , but preserves thymic CD4 + CD25 + Foxp3 + regulatory T cells .
23045606	0	Foxp3	31,36	CD4	27,30	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Neuropilin_1 deficiency on CD4 + Foxp3 + regulatory T cells impairs mouse melanoma growth .
23046932	0	Foxp3	76,81	CD4	61,64	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	CD25|dep|START_ENTITY Influence|dep|CD25 Influence|nmod|END_ENTITY	-LSB- Influence of anti-ICOS antibody on quantity and function of CD4 -LRB- + -RRB- ; CD25 -LRB- + -RRB- ; Foxp3 -LRB- + -RRB- ; Treg from lymph and blood of rats with bronchial_asthma -RSB- .
23127412	0	Foxp3	36,41	CD4	19,22	Foxp3	CD4	50943	920	Gene	Gene	CD25|dep|START_ENTITY END_ENTITY|dep|CD25	-LSB- The subpopulation CD4 -LRB- + -RRB- ; CD25 -LRB- + -RRB- ; Foxp3 -LRB- + -RRB- ; / CD127 -LRB- low / - -RRB- ; regulatory T cells in peripheral blood of HIV-infected patients correlated with disease progression -RSB- .
23128958	0	Foxp3	43,48	CD4	39,42	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Macrophages overexpressing Aire induce CD4 + Foxp3 + T cells .
23185797	0	Foxp3	9,14	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|compound|END_ENTITY	CD4 + CD25 + Foxp3 + Treg and TGF-beta play important roles in pathogenesis of Uygur cervical_carcinoma .
23186751	0	Foxp3	9,14	CD4	0,3	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	CD4 + CD25 + Foxp3 + T cells contribute to the antiasthmatic effects of Astragalus membranaceus extract in a rat model of asthma .
23277487	0	Foxp3	51,56	CD4	47,50	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	TNFR2 is critical for the stabilization of the CD4 + Foxp3 + regulatory T. cell phenotype in the inflammatory environment .
23284056	0	Foxp3	30,35	CD4	26,29	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Varicella zoster-specific CD4 + Foxp3 + T cells accumulate after cutaneous antigen challenge in humans .
23436577	0	Foxp3	44,49	CD4	39,42	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Beta2-adrenergic_receptor signaling in CD4 + Foxp3 + regulatory T cells enhances their suppressive function in a PKA-dependent manner .
23467933	0	Foxp3	39,44	CD4	35,38	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Antigen-specific memory regulatory CD4 + Foxp3 + T cells control memory responses to influenza_virus_infection .
23530124	0	Foxp3	35,40	CD4	74,77	Foxp3	CD4	50943	920	Gene	Gene	development|compound|START_ENTITY development|amod|END_ENTITY	The thymic medulla is required for Foxp3 + regulatory but not conventional CD4 + thymocyte development .
23537702	0	Foxp3	65,70	CD4	59,62	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Systematic evaluation of 640 FDA drugs for their effect on CD4 Foxp3 regulatory T cells using a novel cell-based high throughput screening assay .
23547099	0	Foxp3	65,70	CD4	61,64	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	development|compound|START_ENTITY development|compound|END_ENTITY	Epithelial and dendritic cells in the thymic medulla promote CD4 + Foxp3 + regulatory T cell development via the CD27-CD70 pathway .
23595594	0	Foxp3	83,88	CD4	68,71	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|increase increase|nmod|CD25 CD25|compound|END_ENTITY	Radiofrequency ablation does not induce the significant increase of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells compared with surgical resection in Hepal-6 tumor model .
23632310	0	Foxp3	144,149	CD4	131,134	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	effects|acl|START_ENTITY effects|nmod|CD25 CD25|compound|END_ENTITY	Immunoregulatory effects of glycyrrhizic_acid exerts anti-asthmatic effects via modulation of Th1/Th2 cytokines and enhancement of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 + regulatory T cells in ovalbumin-sensitized mice .
23725550	0	Foxp3	89,94	CD4	79,82	Foxp3	CD4	50943	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Low-dose temozolomide before dendritic-cell vaccination reduces -LRB- specifically -RRB- CD4 + CD25 + + Foxp3 + regulatory T-cells in advanced melanoma patients .
23733880	0	Foxp3	132,137	CD4	149,152	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	novo|compound|START_ENTITY novo|nmod|cells cells|compound|END_ENTITY	Cutting edge : inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103 + but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4 + T cells and promote airway tolerance .
23734780	0	Foxp3	43,48	CD4	34,37	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
23749427	0	Foxp3	66,71	CD4	55,58	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
23750800	0	Foxp3	91,96	CD4	98,101	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3 + CD4 + graft infiltrating cells .
23773923	0	Foxp3	28,33	CD4	35,38	Foxp3	CD4	50943	920	Gene	Gene	role|nmod|START_ENTITY +|nsubj|role +|dobj|cells cells|nummod|END_ENTITY	The role of IL-17-producing Foxp3 + CD4 + T cells in inflammatory_bowel_disease and colon_cancer .
23859136	0	Foxp3	98,103	CD4	105,108	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Loss of b-arrestin 2 exacerbates experimental_autoimmune_encephalomyelitis with reduced number of Foxp3 + CD4 + regulatory T cells .
23881298	0	Foxp3	9,14	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	CD4 + CD25 + Foxp3 regulatory T cells and vascular_dysfunction in hypertension .
23922690	0	Foxp3	15,20	CD4	11,14	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Regulatory CD4 + Foxp3 + T cells control the severity of anaphylaxis .
23949701	0	Foxp3	35,40	CD4	22,25	Foxp3	CD4	50943	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute_respiratory_distress_syndrome is associated with increased 30-day mortality .
23956419	0	Foxp3	13,18	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 CD25 Foxp3 regulatory T cells promote Th17 responses and genital tract inflammation upon intracellular Chlamydia muridarum infection .
24055067	0	Foxp3	86,91	CD4	0,3	Foxp3	CD4	50943	12504(Tax:10090)	Gene	Gene	Tregs|compound|START_ENTITY independent|nmod|Tregs T|xcomp|independent inhibits|ccomp|T inhibits|nsubj|blockade blockade|compound|END_ENTITY	CD4 blockade directly inhibits mouse and human CD4 -LRB- + -RRB- T cell functions independent of Foxp3 -LRB- + -RRB- Tregs .
24055067	0	Foxp3	86,91	CD4	47,50	Foxp3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY independent|nmod|Tregs T|xcomp|independent T|nsubj|END_ENTITY	CD4 blockade directly inhibits mouse and human CD4 -LRB- + -RRB- T cell functions independent of Foxp3 -LRB- + -RRB- Tregs .
24076465	0	Foxp3	45,50	CD4	77,80	Foxp3	CD4	50943	920	Gene	Gene	T|nsubj|START_ENTITY T|dobj|cells cells|nmod|lymphocytes lymphocytes|amod|co-cultured co-cultured|dep|END_ENTITY	Human lung fibroblasts increase CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells in co-cultured CD4 -LRB- + -RRB- lymphocytes .
24097227	0	Foxp3	58,63	CD4	75,78	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|acl|expressing expressing|dobj|cells cells|compound|END_ENTITY	Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4 + T cells and defective suppressive function of circulating Foxp3 + regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory_bowel_disease patients .
24098053	0	Foxp3	29,34	CD4	25,28	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Reduced effectiveness of CD4 + Foxp3 + regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune_thyroiditis .
24151582	0	Foxp3	100,105	CD4	85,88	Foxp3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Chronic_heat_stress inhibits immune responses to H5N1 vaccination through regulating CD4 CD25 Foxp3 Tregs .
24155942	0	Foxp3	58,63	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	converted|nmod|START_ENTITY CD62L|acl:relcl|converted CD62L|compound|END_ENTITY	CD4 -LRB- + -RRB- CD62L -LRB- + -RRB- central memory_T cells can be converted to Foxp3 -LRB- + -RRB- T cells .
24339053	0	Foxp3	151,156	CD4	140,143	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
24366217	0	Foxp3	169,174	CD4	156,159	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased expression of herpesvirus entry mediator in 1,25-dihydroxyvitamin _ D3-treated mouse bone marrow-derived dendritic cells promotes the generation of CD4 CD25 Foxp3 regulatory T cells .
24369813	0	Foxp3	31,36	CD4	0,3	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	gene|dep|START_ENTITY T|dep|gene T|compound|END_ENTITY	CD4 CD25 FOXP3 T cells , Foxp3 gene and protein expression contribute to antiasthmatic effects of San ` ao_decoction in mice model of asthma .
24391000	0	Foxp3	33,38	CD4	105,108	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nmod|detection detection|nmod|cells cells|nummod|END_ENTITY	Application and effects of mouse Foxp3 antibody and fixation/permeabilization buffer on the detection of CD4 + regulatory T cells in various mammal species .
24452947	0	Foxp3	44,49	CD4	33,36	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24465502	0	Foxp3	60,65	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing +|dobj|cells +|nsubj|END_ENTITY	CD4 + primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10 , suppressing CD4 and CD8 T cells .
24465502	0	Foxp3	60,65	CD4	89,92	Foxp3	CD4	50943	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing +|dobj|cells +|advcl|suppressing suppressing|dobj|cells cells|compound|END_ENTITY	CD4 + primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10 , suppressing CD4 and CD8 T cells .
24557710	0	Foxp3	137,142	CD4	128,131	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Narrowband ultraviolet B phototherapy ameliorates acute_graft-versus-host_disease by a mechanism involving in vivo expansion of CD4 + CD25 + Foxp3 + regulatory T cells .
24617045	0	Foxp3	29,34	CD4	19,22	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|Role Role|nmod|CD25 CD25|compound|END_ENTITY	Role of regulatory CD4 + CD25 + Foxp3 T cells in bronchial asthma in Egyptian children .
24668348	0	Foxp3	57,62	CD4	44,47	Foxp3	CD4	50943	920	Gene	Gene	suppresses|amod|START_ENTITY suppresses|nummod|CD69 CD69|compound|END_ENTITY	Human hepatocellular_carcinoma-infiltrating CD4 CD69 Foxp3 regulatory T cell suppresses T cell response via membrane-bound TGF-b1 .
24690994	0	Foxp3	130,135	CD4	69,72	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	downregulation|amod|START_ENTITY suppression|nmod|downregulation +|dobj|suppression Foxp3|acl|+ Foxp3|nummod|+25 +25|compound|END_ENTITY	Transgene IL-6 enhances DC-stimulated CTL responses by counteracting CD4 +25 + Foxp3 + regulatory T cell suppression via IL-6-induced Foxp3 downregulation .
24690994	0	Foxp3	76,81	CD4	69,72	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nummod|+25 +25|compound|END_ENTITY	Transgene IL-6 enhances DC-stimulated CTL responses by counteracting CD4 +25 + Foxp3 + regulatory T cell suppression via IL-6-induced Foxp3 downregulation .
24774748	0	Foxp3	13,18	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 CD25 Foxp3 T cells : a marker for lupus_nephritis ?
24786398	0	Foxp3	0,5	CD4	7,10	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	Foxp3 + CD4 + T cells improve healing after myocardial_infarction by modulating monocyte/macrophage differentiation .
24798620	0	Foxp3	42,47	CD4	29,32	Foxp3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	TGF-b-dependent induction of CD4 CD25 Foxp3 Tregs by liver sinusoidal endothelial cells .
24813240	0	Foxp3	104,109	CD4	87,90	Foxp3	CD4	50943	920	Gene	Gene	Interleukin-17|dep|START_ENTITY Interleukin-17|dep|facilitates facilitates|dobj|capacity capacity|nmod|CD25 CD25|compound|END_ENTITY	Interleukin-17 facilitates the immune suppressor capacity of high-grade glioma-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells via releasing transforming_growth_factor_beta .
24832045	0	Foxp3	72,77	CD4	68,71	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-Cells|compound|START_ENTITY T-Cells|compound|END_ENTITY	The Biology of Autoimmune Response in the Scurfy Mice that Lack the CD4 + Foxp3 + Regulatory T-Cells .
24931519	0	Foxp3	19,24	CD4	39,42	Foxp3	CD4	50943	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|CD25 CD25|compound|END_ENTITY	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
25030097	0	Foxp3	62,67	CD4	49,52	Foxp3	CD4	50943	920	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Comment on Adamzik et al. : An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory_distress_syndrome is associated with increased 30-day mortality .
25054604	0	Foxp3	134,139	CD4	121,124	Foxp3	CD4	50943	920	Gene	Gene	Treg|compound|START_ENTITY Treg|nummod|END_ENTITY	Patients with systemic_lupus_erythematosus and secondary_antiphospholipid_syndrome have decreased numbers of circulating CD4 CD25 Foxp3 Treg and CD3 CD19 B cells .
25139358	0	Foxp3	11,16	CD4	6,9	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Donor CD4 + Foxp3 + regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice .
25193380	0	Foxp3	69,74	CD4	51,54	Foxp3	CD4	50943	920	Gene	Gene	targets|dep|START_ENTITY targets|nmod|CD25 CD25|compound|END_ENTITY	Epigenetic enzymes are the therapeutic targets for CD4 -LRB- + -RRB- CD25 -LRB- + / high -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
25199644	0	Foxp3	56,61	CD4	52,55	Foxp3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	Foxp3	56,61	CD4	70,73	Foxp3	CD4	50943	920	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs CXCR5|dep|Bregs CXCR5|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	Foxp3	80,85	CD4	52,55	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|numbers numbers|nmod|CXCR5 CXCR5|dep|Bregs Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	Foxp3	80,85	CD4	70,73	Foxp3	CD4	50943	920	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|numbers numbers|nmod|CXCR5 CXCR5|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25271532	0	Foxp3	85,90	CD4	91,94	Foxp3	CD4	50943	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Mono-allergic and poly-allergic_rhinitis patients have comparable numbers of mucosal Foxp3 + CD4 + T lymphocytes .
25275597	0	Foxp3	4,9	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	differentiation|compound|START_ENTITY differentiation|compound|END_ENTITY	CD4 + Foxp3 + regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic_lesions .
25393309	0	Foxp3	124,129	CD4	54,57	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY resistant|nmod|cells resistant|nsubj|cells cells|compound|END_ENTITY	BDC12-4 .1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3 + T regulatory cells .
25522145	0	Foxp3	31,36	CD4	27,30	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Ameliorate|compound|START_ENTITY Ameliorate|compound|END_ENTITY	Parasitic Nematode-Induced CD4 + Foxp3 + T Cells Can Ameliorate Allergic Airway Inflammation .
25523567	0	Foxp3	23,28	CD4	10,13	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|Roles Roles|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Roles of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and IL-33 in the pathogenesis of asthma in children -RSB- .
25548231	0	Foxp3	39,44	CD4	76,79	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY defines|nsubj|regulation defines|dobj|population population|nmod|cells cells|nummod|END_ENTITY	Cutting edge : epigenetic regulation of Foxp3 defines a stable population of CD4 + regulatory T cells in tumors from mice and humans .
25560411	0	Foxp3	104,109	CD4	51,54	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|CD25 CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
25581421	0	Foxp3	43,48	CD4	60,63	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	LAG3|compound|START_ENTITY Studies|nmod|LAG3 END_ENTITY|nsubj|Studies	Characterization and Functional Studies of Foxp3 -LRB- - -RRB- LAG3 -LRB- + -RRB- CD4 -LRB- + -RRB- Regulatory T Cells Induced by Mucosal B Cells .
25595257	0	Foxp3	100,105	CD4	91,94	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4 + CD25 + Foxp3 + T cells -LRB- Tregs -RRB- in a mouse study for active DNA Ab42 immunotherapy .
25701137	0	Foxp3	74,79	CD4	70,73	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Methionine_enkephalin -LRB- MENK -RRB- inhibits tumor growth through regulating CD4 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- in mice .
25712878	0	Foxp3	44,49	CD4	53,56	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Deficiency of decorin induces expression of Foxp3 in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells in a murine model of allergic_asthma .
25771887	0	Foxp3	38,43	CD4	48,51	Foxp3	CD4	50943	920	Gene	Gene	role|nmod|START_ENTITY /|nsubj|role /|iobj|IL-17A IL-17A|compound|END_ENTITY	The possible role of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- / CD4 -LRB- + -RRB- IL-17A -LRB- + -RRB- cell imbalance in the autoimmunity of patients with Hashimoto_thyroiditis .
25772268	0	Foxp3	97,102	CD4	90,93	Foxp3	CD4	50943	920	Gene	Gene	CD25|compound|START_ENTITY CD25|nummod|END_ENTITY	The effect of extracorporeal photopheresis alone or in combination therapy on circulating CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells in patients with leukemic cutaneous_T-cell_lymphoma .
25848068	0	Foxp3	51,56	CD4	88,91	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Edge|dep|Regulation Comment|nmod|Edge Defines|nsubj|Comment Defines|dobj|Population Population|nmod|Cells Cells|compound|END_ENTITY	Comment on `` Cutting Edge : Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4 + Regulatory T Cells in Tumors from Mice and Humans '' .
25848069	0	Foxp3	63,68	CD4	100,103	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Edge|dep|Regulation Comment|nmod|Edge Response|nmod|Comment Defines|nsubj|Response Defines|dobj|Population Population|nmod|cells cells|compound|END_ENTITY	Response to Comment on `` Cutting Edge : Epigenetic Regulation of Foxp3 Defines a Stable Population of CD4 + Regulatory T cells in Tumors from Mice and Humans '' .
25915882	0	Foxp3	24,29	CD4	30,33	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Decreased proportion of Foxp3 + CD4 + regulatory T cells contributes to the development of hypertension in genetically hypertensive rats .
25915882	0	Foxp3	24,29	CD4	30,33	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Decreased proportion of Foxp3 + CD4 + regulatory T cells contributes to the development of hypertension in genetically hypertensive rats .
25973010	0	Foxp3	31,36	CD4	51,54	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	BTLA associates with increased Foxp3 expression in CD4 -LRB- + -RRB- T cells in dextran sulfate sodium-induced colitis .
26004193	0	Foxp3	63,68	CD4	59,62	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vitamin_A supplementation leads to increases in regulatory CD4 + Foxp3 + LAP + T cells in mice .
26063731	0	Foxp3	28,33	CD4	48,51	Foxp3	CD4	50943	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|T-cells T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	Foxp3	57,62	CD4	48,51	Foxp3	CD4	50943	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26214407	0	Foxp3	26,31	CD4	15,18	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	Treg|compound|START_ENTITY +|dobj|Treg +|nsubj|Correlation Correlation|nmod|CD25 CD25|compound|END_ENTITY	Correlation of CD4 + CD25 + Foxp3 + Treg with the recovery of joint function after total knee replacement in rats with osteoarthritis .
26251265	0	Foxp3	132,137	CD4	125,128	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|amod|transforming_growth_factor-b transforming_growth_factor-b|nmod|expression expression|nmod|CD73 CD73|nmod|END_ENTITY	1a,25-dihydroxyvitamin _ D3 acts via transforming_growth_factor-b to up-regulate expression of immunosuppressive CD73 on human CD4 -LRB- + -RRB- Foxp3 -LRB- - -RRB- T cells .
26273136	0	Foxp3	42,47	CD4	29,32	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cells|nsubj|START_ENTITY CD25|xcomp|Cells CD25|nsubj|Effect Effect|nmod|END_ENTITY	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
26283421	0	Foxp3	13,18	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- T cells play a role in tuberculous_hydrothorax rather than malignant hydrothorax .
26283421	0	Foxp3	13,18	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- Foxp3 -LRB- + -RRB- T cells play a role in tuberculous_hydrothorax rather than malignant hydrothorax .
26309858	0	Foxp3	120,125	CD4	110,113	Foxp3	CD4	317382(Tax:10116)	24932(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells CD25|acl|+ CD25|compound|END_ENTITY	Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4 + CD25 + Foxp3 regulatory T cells .
26438270	0	Foxp3	106,111	CD4	93,96	Foxp3	CD4	50943	920	Gene	Gene	generation|amod|START_ENTITY correlates|dobj|generation correlates|nmod|CD25 CD25|compound|END_ENTITY	Up-regulated S100_calcium_binding_protein_A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
26453746	0	Foxp3	61,66	CD4	27,30	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Induction|compound|START_ENTITY +|dobj|Induction +|nsubj|Expression Expression|nmod|END_ENTITY	Eomesodermin Expression in CD4 + T Cells Restricts Peripheral Foxp3 Induction .
26495986	0	Foxp3	126,131	CD4	122,125	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4 + Foxp3 + Regulatory T Cells .
26553468	0	Foxp3	71,76	CD4	15,18	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|nummod|END_ENTITY	Suppression of CD4 + effector responses by naturally occurring CD4 + CD25 + Foxp3 + regulatory T cells contribute to experimental cerebral_malaria .
26590147	0	Foxp3	55,60	CD4	51,54	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Effect of bacillus Calmette-Gu rin vaccination on CD4 + Foxp3 + T cells during acquired immune response to Mycobacterium_tuberculosis infection .
26604855	0	Foxp3	47,52	CD4	63,66	Foxp3	CD4	50943	920	Gene	Gene	CD4|compound|START_ENTITY infiltrating|dobj|CD4 T|advcl|infiltrating T|nsubj|END_ENTITY	The prognostic influence of tumor infiltrating Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- , CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells in resected non-small_cell_lung_cancer .
26615520	0	Foxp3	89,94	CD4	76,79	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|nmod|CD25 CD25|compound|END_ENTITY	Human umbilical vein endothelial cells promote the inhibitory activation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via PD-L1 .
26631955	0	Foxp3	137,142	CD4	113,116	Foxp3	CD4	50943	920	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	CD19 -LRB- + -RRB- IL-10 -LRB- + -RRB- regulatory B cells affect survival of tongue_squamous_cell_carcinoma patients and induce resting CD4 -LRB- + -RRB- T cells to CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
26673565	0	Foxp3	16,21	CD4	0,3	Foxp3	CD4	50943	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- Treg_deficiency in a Brazilian patient with Gaucher_disease and lupus_nephritis .
26678292	0	Foxp3	118,123	CD4	105,108	Foxp3	CD4	50943	920	Gene	Gene	generation|nummod|START_ENTITY correlates|nsubj|generation correlates|nmod|CD25 CD25|compound|END_ENTITY	Erratum to : Up-regulated S100 calcium binding protein A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
26752376	0	Foxp3	61,66	CD4	22,25	Foxp3	CD4	50943	920	Gene	Gene	cells|nmod|START_ENTITY Conditioning|dobj|cells Conditioning|nmod|T T|compound|END_ENTITY	Conditioning of naive CD4 -LRB- + -RRB- T cells for enhanced peripheral Foxp3 induction by nonspecific bystander_inflammation .
26862849	0	Foxp3	22,27	CD4	13,16	Foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|Frequency Frequency|nmod|CD25 CD25|compound|END_ENTITY	Frequency of CD4 + CD25 + Foxp3 + cells in peripheral blood in relation to urinary bladder_cancer malignancy indicators before and after surgical removal .
26886923	0	Foxp3	54,59	CD4	50,53	Foxp3	CD4	50943	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Comparative Analysis of Protocols to Induce Human CD4 + Foxp3 + Regulatory T Cells by Combinations of IL-2 , TGF-beta , Retinoic_Acid , Rapamycin and Butyrate .
26927553	0	Foxp3	18,23	CD4	69,72	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Tubacin promotes Foxp3 expression and suppressive function of mouse CD4 -LRB- + -RRB- ; CD25 -LRB- + -RRB- ; regulatory T cells -RSB- .
27016139	0	Foxp3	91,96	CD4	111,114	Foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inducing|dobj|expression inducing|nmod|cells cells|compound|END_ENTITY	Granulocytic myeloid-derived suppressor cells maintain feto-maternal tolerance by inducing Foxp3 expression in CD4 + CD25-T cells by activation of the TGF-b/b-catenin pathway .
23858029	0	Foxp3	83,88	CD40	34,38	Foxp3	CD40	50943	958	Gene	Gene	+|compound|START_ENTITY sufficient|nmod|+ sufficient|nsubj|Inhibition Inhibition|nmod|signals signals|compound|END_ENTITY	Inhibition of CD8 + T cell-derived CD40 signals is necessary but not sufficient for Foxp3 + induced regulatory T cell generation in vivo .
25199644	0	Foxp3	56,61	CD5	21,24	Foxp3	CD5	50943	921	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs Bregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
23749427	0	Foxp3	66,71	CD73	0,4	Foxp3	CD73	50943	4907	Gene	Gene	cells|compound|START_ENTITY derived|nmod|cells vesicles|acl|derived expression|nmod|vesicles expression|nummod|END_ENTITY	CD73 expression on extracellular vesicles derived from CD4 + CD25 + Foxp3 + T cells contributes to their regulatory function .
17720157	0	Foxp3	42,47	CD8	50,53	Foxp3	CD8	50943	925	Gene	Gene	CD25|amod|START_ENTITY CD25|compound|END_ENTITY	Transforming_growth_factor_beta-producing Foxp3 -LRB- + -RRB- CD8 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells induced by iris pigment_epithelial cells display regulatory phenotype and acquire regulatory functions .
17921346	0	Foxp3	15,20	CD8	82,85	Foxp3	CD8	50943	925	Gene	Gene	leads|amod|START_ENTITY mediated|dobj|leads mediated|nmod|generation generation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8 + cytotoxic T lymphocytes .
19022917	0	Foxp3	27,32	CD8	18,21	Foxp3	CD8	50943	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal_cancer tissue .
19616200	0	Foxp3	79,84	CD8	15,18	Foxp3	CD8	50943	925	Gene	Gene	granzyme_B|appos|START_ENTITY expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19620303	0	Foxp3	20,25	CD8	49,52	Foxp3	CD8	50943	925	Gene	Gene	+|amod|START_ENTITY development|nmod|+ thymocytes|nsubj|development thymocytes|nmod|subset subset|compound|END_ENTITY	Rare development of Foxp3 + thymocytes in the CD4 + CD8 + subset .
20042455	0	Foxp3	26,31	CD8	32,35	Foxp3	CD8	50943	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	IL-6 positively regulates Foxp3 + CD8 + T cells in vivo .
20142839	0	Foxp3	0,5	CD8	61,64	Foxp3	CD8	50943	925	Gene	Gene	induction|amod|START_ENTITY precedes|nsubj|induction precedes|dobj|stage stage|compound|END_ENTITY	Foxp3 induction in human and murine thymus precedes the CD4 + CD8 + stage but requires early T-cell receptor expression .
20181533	0	Foxp3	19,24	CD8	88,91	Foxp3	CD8	50943	925	Gene	Gene	cells|amod|START_ENTITY Enrichment|nmod|cells correlates|nsubj|Enrichment correlates|nmod|function function|compound|END_ENTITY	Enrichment of CCR6 + Foxp3 + regulatory T cells in the tumor mass correlates with impaired CD8 + T cell function and poor prognosis of breast_cancer .
20221835	0	Foxp3	32,37	CD8	63,66	Foxp3	CD8	50943	925	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	Higher intratumoral infiltrated Foxp3 + Treg numbers and Foxp3 + / CD8 + ratio are associated with adverse prognosis in resectable gastric_cancer .
20639494	0	Foxp3	0,5	CD8	80,83	Foxp3	CD8	50943	925	Gene	Gene	cells|compound|START_ENTITY limit|nsubj|cells limit|advcl|modulating modulating|dobj|response response|compound|END_ENTITY	Foxp3 + CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory_syncytial_virus_infection .
21312192	0	Foxp3	5,10	CD8	0,3	Foxp3	CD8	20371(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21312192	0	Foxp3	84,89	CD8	0,3	Foxp3	CD8	20371(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY share|nmod|cells share|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21352252	0	Foxp3	26,31	CD8	77,80	Foxp3	CD8	50943	925	Gene	Gene	IL-17|compound|START_ENTITY T|nsubj|IL-17 T|ccomp|suppress suppress|dobj|cells cells|compound|END_ENTITY	Colorectal_cancer-derived Foxp3 -LRB- + -RRB- IL-17 -LRB- + -RRB- T cells suppress tumour-specific CD8 + T cells .
21469126	0	Foxp3	58,63	CD8	42,45	Foxp3	CD8	50943	925	Gene	Gene	CTLA-4|compound|START_ENTITY CTLA-4|compound|END_ENTITY	Human plasmacytoid dendritic cells induce CD8 LAG-3 Foxp3 CTLA-4 regulatory T cells that suppress allo-reactive memory T cells .
21518973	0	Foxp3	9,14	CD8	67,70	Foxp3	CD8	50943	925	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|dispensable dispensable|nmod|lung_inflammation lung_inflammation|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung_inflammation .
22609353	0	Foxp3	73,78	CD8	64,67	Foxp3	CD8	50943	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Porcine_reproductive_and_respiratory_syndrome_virus induces CD4 + CD8 + CD25 + Foxp3 + regulatory T cells -LRB- Tregs -RRB- .
22681667	0	Foxp3	20,25	CD8	15,18	Foxp3	CD8	50943	925	Gene	Gene	cells|amod|START_ENTITY protect|nsubj|cells +|ccomp|protect +|nsubj|END_ENTITY	Donor-specific CD8 + Foxp3 + T cells protect skin allografts and facilitate induction of conventional CD4 + Foxp3 + regulatory T cells .
23858029	0	Foxp3	83,88	CD8	14,17	Foxp3	CD8	50943	925	Gene	Gene	+|compound|START_ENTITY sufficient|nmod|+ sufficient|nsubj|Inhibition Inhibition|nmod|signals signals|compound|END_ENTITY	Inhibition of CD8 + T cell-derived CD40 signals is necessary but not sufficient for Foxp3 + induced regulatory T cell generation in vivo .
25548225	0	Foxp3	99,104	CD8	112,115	Foxp3	CD8	50943	925	Gene	Gene	START_ENTITY|nmod|Promoter Promoter|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
25548225	0	Foxp3	99,104	CD8	40,43	Foxp3	CD8	50943	925	Gene	Gene	Methylation|nmod|START_ENTITY Methylation|nmod|Binding Binding|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
17911604	0	Foxp3	64,69	CTLA-4	23,29	Foxp3	CTLA-4	20371(Tax:10090)	12477(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induces|dobj|+ induces|nsubj|engagement engagement|nmod|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
18845758	0	Foxp3	20,25	CTLA-4	0,6	Foxp3	CTLA-4	50943	1493	Gene	Gene	cell|amod|START_ENTITY control|nmod|cell control|compound|END_ENTITY	CTLA-4 control over Foxp3 + regulatory T cell function .
22749982	0	Foxp3	54,59	CTLA-4	20,26	Foxp3	CTLA-4	50943	1493	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|CD152 CD152|appos|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
22910217	0	Foxp3	16,21	CTLA-4	0,6	Foxp3	CTLA-4	50943	1493	Gene	Gene	induction|amod|START_ENTITY promotes|dobj|induction promotes|nsubj|END_ENTITY	CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria .
24007441	0	Foxp3	66,71	CTLA-4	112,118	Foxp3	CTLA-4	50943	1493	Gene	Gene	START_ENTITY|acl|iTreg iTreg|nmod|absence absence|nmod|Ig Ig|compound|END_ENTITY	An anti-CD154 domain antibody prolongs graft survival and induces Foxp3 -LRB- + -RRB- iTreg in the absence and presence of CTLA-4 Ig .
20488788	0	Foxp3	105,110	CTLA4	141,146	Foxp3	CTLA4	20371(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23 / Th17 axis and induction of Foxp3 + regulatory T cells involving CTLA4 signaling in a psoriasis-like skin_disorder .
26273136	0	Foxp3	42,47	CXCR3	21,26	Foxp3	CXCR3	20371(Tax:10090)	12766(Tax:10090)	Gene	Gene	Cells|nsubj|START_ENTITY CD25|xcomp|Cells CD25|nsubj|Effect Effect|nmod|CD4 CD4|compound|END_ENTITY	Protective Effect of CXCR3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory T Cells in Renal_Ischemia-Reperfusion_Injury .
25199644	0	Foxp3	56,61	CXCR5	74,79	Foxp3	CXCR5	50943	643	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs END_ENTITY|dep|Bregs	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
20439537	0	Foxp3	86,91	Cbl-b	60,65	Foxp3	Cbl-b	20371(Tax:10090)	208650(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells .
25560411	0	Foxp3	104,109	Cbl-b	20,25	Foxp3	Cbl-b	20371(Tax:10090)	208650(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|CD25 CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
26684629	0	Foxp3	9,14	Cd25	4,8	Foxp3	Cd25	50943	3559	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
26684629	0	Foxp3	9,14	Cd4	0,3	Foxp3	Cd4	50943	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
26198700	0	Foxp3	36,41	Cyclin-dependent_kinase_5	0,25	Foxp3	Cyclin-dependent kinase 5	20371(Tax:10090)	12568(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727 .
25560411	0	Foxp3	104,109	E3_Ubiquitin_Ligase	0,19	Foxp3	E3 Ubiquitin Ligase	20371(Tax:10090)	68350(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|CD25 CD25|compound|END_ENTITY	E3_Ubiquitin_Ligase Cbl-b Regulates Thymic-Derived CD4 + CD25 + Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination .
20574810	0	Foxp3	58,63	Ets-1	32,37	Foxp3	Ets-1	50943	2113	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Methylation matters : binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells .
24369813	0	Foxp3	31,36	FOXP3	13,18	Foxp3	FOXP3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	gene|dep|START_ENTITY T|dep|gene T|compound|END_ENTITY	CD4 CD25 FOXP3 T cells , Foxp3 gene and protein expression contribute to antiasthmatic effects of San ` ao_decoction in mice model of asthma .
18477692	0	Foxp3	75,80	Foxp3	95,100	Foxp3	Foxp3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion/differentiation|nmod|+ IL-1|nmod|expansion/differentiation END_ENTITY|amod|IL-1	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
18477692	0	Foxp3	95,100	Foxp3	75,80	Foxp3	Foxp3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|amod|IL-1 IL-1|nmod|expansion/differentiation expansion/differentiation|nmod|+ +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
21312192	0	Foxp3	5,10	Foxp3	84,89	Foxp3	Foxp3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY share|nsubj|cells share|nmod|cells cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21312192	0	Foxp3	84,89	Foxp3	5,10	Foxp3	Foxp3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY share|nmod|cells share|nsubj|cells cells|compound|END_ENTITY	CD8 + Foxp3 + T cells share developmental and phenotypic features with classical CD4 + Foxp3 + regulatory T cells but lack potent suppressive activity .
21419767	0	Foxp3	24,29	Foxp3	76,81	Foxp3	Foxp3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	Interleukin-12 converts Foxp3 + regulatory T cells to interferon-y-producing Foxp3 + T cells that inhibit colitis .
21419767	0	Foxp3	76,81	Foxp3	24,29	Foxp3	Foxp3	20371(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	Interleukin-12 converts Foxp3 + regulatory T cells to interferon-y-producing Foxp3 + T cells that inhibit colitis .
21472340	0	Foxp3	67,72	Foxp3	96,101	Foxp3	Foxp3	50943	50943	Gene	Gene	START_ENTITY|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
21472340	0	Foxp3	96,101	Foxp3	67,72	Foxp3	Foxp3	50943	50943	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells END_ENTITY|dep|cells	Renal_cell_carcinoma may evade the immune system by converting CD4 + Foxp3 - T cells into CD4 + CD25 + Foxp3 + regulatory T cells : Role of tumor COX-2-derived PGE2 .
24064667	0	Foxp3	124,129	Foxp3	55,60	Foxp3	Foxp3	50943	50943	Gene	Gene	cells|amod|START_ENTITY exhibit|nmod|cells exhibit|nsubj|cells cells|compound|END_ENTITY	Highly prevalent colorectal_cancer-infiltrating LAP Foxp3 T cells exhibit more potent immunosuppressive activity than Foxp3 regulatory T cells .
24064667	0	Foxp3	55,60	Foxp3	124,129	Foxp3	Foxp3	50943	50943	Gene	Gene	cells|compound|START_ENTITY exhibit|nsubj|cells exhibit|nmod|cells cells|amod|END_ENTITY	Highly prevalent colorectal_cancer-infiltrating LAP Foxp3 T cells exhibit more potent immunosuppressive activity than Foxp3 regulatory T cells .
25199644	0	Foxp3	56,61	Foxp3	80,85	Foxp3	Foxp3	50943	50943	Gene	Gene	Tregs|compound|START_ENTITY Bregs|dep|Tregs CXCR5|dep|Bregs numbers|nmod|CXCR5 +|nsubj|numbers +|dobj|cells cells|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
25199644	0	Foxp3	80,85	Foxp3	56,61	Foxp3	Foxp3	50943	50943	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|numbers numbers|nmod|CXCR5 CXCR5|dep|Bregs Bregs|dep|Tregs Tregs|compound|END_ENTITY	Increased numbers of CD5 + CD19 + CD1dhighIL-10 + Bregs , CD4 + Foxp3 + Tregs , CD4 + CXCR5 + Foxp3 + follicular regulatory T -LRB- TFR -RRB- cells in CHB or CHC patients .
26063731	0	Foxp3	28,33	Foxp3	57,62	Foxp3	Foxp3	50943	50943	Gene	Gene	expression|amod|START_ENTITY expression|nmod|T-cells T-cells|compound|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
26063731	0	Foxp3	57,62	Foxp3	28,33	Foxp3	Foxp3	50943	50943	Gene	Gene	T-cells|compound|START_ENTITY expression|nmod|T-cells expression|amod|END_ENTITY	Androgen_receptor modulates Foxp3 expression in CD4 + CD25 + Foxp3 + regulatory T-cells .
19079226	0	Foxp3	24,29	GALT	7,11	Foxp3	GALT	50943	2592	Gene	Gene	cells|amod|START_ENTITY promote|dobj|cells promote|nsubj|DCs DCs|compound|END_ENTITY	CD103 + GALT DCs promote Foxp3 + regulatory T cells .
18930767	0	Foxp3	25,30	GITR	63,67	Foxp3	GITR	20371(Tax:10090)	21936(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion|nmod|+ mediated|nmod|expansion mediated|nmod|molecules molecules|amod|END_ENTITY	In vivo expansion of CD4 + Foxp3 + regulatory T cells mediated by GITR molecules .
21974802	0	Foxp3	0,5	HDAC1	15,20	Foxp3	HDAC1	50943	3065	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Foxp3 inhibits HDAC1 activity to modulate gene expression in human T cells .
24931519	0	Foxp3	19,24	HIF1a	10,15	Foxp3	HIF1a	50943	3091	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
20181882	0	Foxp3	124,129	Helios	14,20	Foxp3	Helios	50943	22807	Gene	Gene	T|compound|START_ENTITY thymic-derived|nmod|T cells|amod|thymic-derived differentiates|dobj|cells differentiates|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Helios , an Ikaros transcription factor family member , differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells .
21677778	0	Foxp3	123,128	Helios	0,6	Foxp3	Helios	20371(Tax:10090)	22779(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY vivo|nmod|expression helper|nmod|vivo differentiating|xcomp|helper cells|acl|differentiating associated|nmod|cells associated|nsubjpass|END_ENTITY	Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression .
23264341	0	Foxp3	0,5	Helios	7,13	Foxp3	Helios	50943	22807	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Foxp3 + Helios + regulatory T cells are expanded in active systemic_lupus_erythematosus .
26495986	0	Foxp3	126,131	Helios	35,41	Foxp3	Helios	20371(Tax:10090)	22779(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Thymus-Derived|nmod|Cells Do|dobj|Thymus-Derived Do|nsubj|Differences Differences|nmod|Level Level|nmod|END_ENTITY	Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4 + Foxp3 + Regulatory T Cells .
19448155	0	Foxp3	26,31	ICOS	32,36	Foxp3	ICOS	20371(Tax:10090)	54167(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
21558138	0	Foxp3	32,37	ICOS	26,30	Foxp3	ICOS	50943	29851	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
22815292	0	Foxp3	54,59	ICOS	0,4	Foxp3	ICOS	20371(Tax:10090)	54167(Tax:10090)	Gene	Gene	generation|nmod|START_ENTITY mediates|dobj|generation mediates|nsubj|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
22850422	0	Foxp3	99,104	ICOS	77,81	Foxp3	ICOS	50943	29851	Gene	Gene	costimulation|nmod|START_ENTITY costimulation|compound|END_ENTITY	Plasmacytoid dendritic cells promote immunosuppression in ovarian_cancer via ICOS costimulation of Foxp3 -LRB- + -RRB- T-regulatory cells .
23319295	0	Foxp3	14,19	ICOS	0,4	Foxp3	ICOS	20371(Tax:10090)	54167(Tax:10090)	Gene	Gene	production|nsubj|START_ENTITY controls|xcomp|production controls|nsubj|END_ENTITY	ICOS controls Foxp3 -LRB- + -RRB- regulatory T-cell expansion , maintenance and IL-10 production during helminth infection .
25946021	0	Foxp3	15,20	ICOS	9,13	Foxp3	ICOS	20371(Tax:10090)	54167(Tax:10090)	Gene	Gene	CXCR3|amod|START_ENTITY +|dobj|CXCR3 +|nsubj|END_ENTITY	Th1-Like ICOS + Foxp3 + Treg Cells Preferentially Express CXCR3 and Home to b-Islets during Pre-Diabetes in BDC2 .5 NOD Mice .
25946021	0	Foxp3	15,20	ICOS	9,13	Foxp3	ICOS	20371(Tax:10090)	54167(Tax:10090)	Gene	Gene	CXCR3|amod|START_ENTITY +|dobj|CXCR3 +|nsubj|END_ENTITY	Th1-Like ICOS + Foxp3 + Treg Cells Preferentially Express CXCR3 and Home to b-Islets during Pre-Diabetes in BDC2 .5 NOD Mice .
16906223	0	Foxp3	34,39	IFN-gamma	8,17	Foxp3	IFN-gamma	20371(Tax:10090)	15978(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
23028594	0	Foxp3	0,5	IFN-y	111,116	Foxp3	IFN-y	50943	3458	Gene	Gene	cells|amod|START_ENTITY cells|dep|impact impact|nmod|END_ENTITY	Foxp3 + regulatory T cells among tuberculosis patients : impact on prognosis and restoration of antigen specific IFN-y producing T cells .
24799116	0	Foxp3	48,53	IFN-y	88,93	Foxp3	IFN-y	50943	3458	Gene	Gene	+|amod|START_ENTITY development|nmod|+ development|dep|cells cells|nmod|END_ENTITY	y T cells restrain extrathymic development of Foxp3 + - inducible regulatory T cells via IFN-y .
18477692	0	Foxp3	75,80	IL-1	25,29	Foxp3	IL-1	20371(Tax:10090)	111343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY expansion/differentiation|nmod|+ END_ENTITY|nmod|expansion/differentiation	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
17675505	0	Foxp3	22,27	IL-10	147,152	Foxp3	IL-10	20371(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reveal|nmod|cells reveal|nmod|source source|nmod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
21558138	0	Foxp3	32,37	IL-10	79,84	Foxp3	IL-10	50943	3586	Gene	Gene	cells|compound|START_ENTITY contribute|nsubj|cells contribute|nmod|overproduction overproduction|nmod|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
24452947	0	Foxp3	44,49	IL-10	146,151	Foxp3	IL-10	50943	3586	Gene	Gene	cells|compound|START_ENTITY induction|nmod|cells contributes|nsubj|induction contributes|nmod|regulation regulation|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
20952660	0	Foxp3	0,5	IL-17	6,11	Foxp3	IL-17	50943	3605	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|compound|END_ENTITY	Foxp3 + IL-17 + T cells promote development of cancer-initiating_cells in colorectal cancer .
21314287	0	Foxp3	22,27	IL-17	16,21	Foxp3	IL-17	50943	3605	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Localization of IL-17 + Foxp3 + T cells in esophageal_cancer .
22455945	0	Foxp3	20,25	IL-17	60,65	Foxp3	IL-17	317382(Tax:10116)	301289(Tax:10116)	Gene	Gene	START_ENTITY|dobj|cells cells|acl:relcl|-RSB- -RSB-|dobj|cells cells|amod|END_ENTITY	-LSB- Changes of CD -LRB- 4 -RRB- -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and CD -LRB- 4 -RRB- -LRB- + -RRB- IL-17 -LRB- + -RRB- T cells in cigarette smoke-exposed rats -RSB- .
22539291	0	Foxp3	0,5	IL-17	71,76	Foxp3	IL-17	50943	3605	Gene	Gene	cells|compound|START_ENTITY insensitive|nsubj|cells insensitive|xcomp|IL-6-driven IL-6-driven|dobj|production production|compound|END_ENTITY	Foxp3 Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production .
24097227	0	Foxp3	58,63	IL-17	42,47	Foxp3	IL-17	50943	3605	Gene	Gene	secreting|dobj|START_ENTITY circulating|advcl|secreting circulating|dobj|END_ENTITY	Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4 + T cells and defective suppressive function of circulating Foxp3 + regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory_bowel_disease patients .
24744433	0	Foxp3	6,11	IL-17	0,5	Foxp3	IL-17	50943	3605	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-17 + Foxp3 + T cells : an intermediate differentiation stage between Th17 cells and regulatory T cells .
18434325	0	Foxp3	0,5	IL-17A	34,40	Foxp3	IL-17A	50943	3605	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat .
25771887	0	Foxp3	38,43	IL-17A	55,61	Foxp3	IL-17A	50943	3605	Gene	Gene	role|nmod|START_ENTITY /|nsubj|role /|iobj|END_ENTITY	The possible role of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- / CD4 -LRB- + -RRB- IL-17A -LRB- + -RRB- cell imbalance in the autoimmunity of patients with Hashimoto_thyroiditis .
25790134	0	Foxp3	55,60	IL-17A	25,31	Foxp3	IL-17A	20371(Tax:10090)	16171(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
21779356	0	Foxp3	41,46	IL-1b	0,5	Foxp3	IL-1b	50943	3553	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	IL-1b promotes TGF-b1 and IL-2 dependent Foxp3 expression in regulatory T cells .
15753206	0	Foxp3	35,40	IL-2	139,143	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	CD4|amod|START_ENTITY maintenance|nmod|CD4 regulatory|nsubj|maintenance regulatory|nmod|neutralization neutralization|compound|END_ENTITY	Homeostatic maintenance of natural Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells by interleukin _ -LRB- IL -RRB- -2 and induction of autoimmune_disease by IL-2 neutralization .
16304057	0	Foxp3	44,49	IL-2	0,4	Foxp3	IL-2	50943	3558	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|administration administration|compound|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
17015695	0	Foxp3	93,98	IL-2	26,30	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	T|compound|START_ENTITY production|nmod|T controlling|dobj|production determinant|acl|controlling determinant|nsubj|availability availability|nmod|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17130555	0	Foxp3	16,21	IL-2	60,64	Foxp3	IL-2	20371(Tax:10090)	3558	Gene	Gene	expression|amod|START_ENTITY Upregulation|nmod|expression implications|nsubj|Upregulation implications|amod|END_ENTITY	Upregulation of Foxp3 expression in mouse and human Treg is IL-2 / STAT5 dependent : implications for the NOD STAT5B mutation in diabetes pathogenesis .
17182565	0	Foxp3	81,86	IL-2	0,4	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY development|nmod|cells required|nmod|development required|nsubjpass|activation activation|compound|END_ENTITY	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells .
17277105	0	Foxp3	72,77	IL-2	0,4	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells convert|dobj|CD25 essential|xcomp|convert essential|nsubj|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17371955	0	Foxp3	67,72	IL-2	14,18	Foxp3	IL-2	50943	3558	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells essential|nmod|induction essential|nsubj|END_ENTITY	Cutting Edge : IL-2 is essential for TGF-beta-mediated induction of Foxp3 + T regulatory cells .
18395858	0	Foxp3	80,85	IL-2	17,21	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY role|nmod|Treg role|nmod|END_ENTITY	Critical role of IL-2 and TGF-beta in generation , function and stabilization of Foxp3 + CD4 + Treg .
18490709	0	Foxp3	14,19	IL-2	60,64	Foxp3	IL-2	50943	3558	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|resistant resistant|nsubj|cells cells|acl|induced induced|nmod|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18493984	0	Foxp3	49,54	IL-2	0,4	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|dep|END_ENTITY	IL-2 induces in vivo suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18941219	0	Foxp3	51,56	IL-2	21,25	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY variants|nmod|cell variants|compound|END_ENTITY	Impact of protective IL-2 allelic variants on CD4 + Foxp3 + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice .
20081380	0	Foxp3	70,75	IL-2	24,28	Foxp3	IL-2	50943	3558	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells END_ENTITY|nmod|expansion	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
21059266	0	Foxp3	52,57	IL-2	0,4	Foxp3	IL-2	50943	3558	Gene	Gene	function|compound|START_ENTITY restoration|nmod|function target|nmod|restoration END_ENTITY|nmod|target	IL-2 as a therapeutic target for the restoration of Foxp3 + regulatory T cell function in organ-specific autoimmunity : implications in pathophysiology and translation to human disease .
21244339	0	Foxp3	44,49	IL-2	0,4	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	expansion|nsubj|START_ENTITY promotes|xcomp|expansion promotes|nsubj|production production|compound|END_ENTITY	IL-2 production by dendritic cells promotes Foxp3 -LRB- + -RRB- regulatory T-cell expansion in autoimmune-resistant NOD congenic mice .
21389253	0	Foxp3	54,59	IL-2	0,4	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY balance|nmod|cells maintaining|dobj|balance contributes|advcl|maintaining contributes|nsubj|END_ENTITY	IL-2 contributes to maintaining a balance between CD4 + Foxp3 + regulatory T cells and effector CD4 + T cells required for immune control of blood-stage malaria_infection .
21525380	0	Foxp3	31,36	IL-2	0,4	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stability|nmod|expression controls|dobj|stability controls|nsubj|END_ENTITY	IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3 + T cells in vivo .
21525380	0	Foxp3	68,73	IL-2	0,4	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY controls|nmod|cells controls|nsubj|END_ENTITY	IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3 + T cells in vivo .
23126599	0	Foxp3	47,52	IL-2	83,87	Foxp3	IL-2	50943	3558	Gene	Gene	CD4|compound|START_ENTITY induction|nmod|CD4 END_ENTITY|nsubj|induction	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
23884888	0	Foxp3	45,50	IL-2	16,20	Foxp3	IL-2	20371(Tax:10090)	16183(Tax:10090)	Gene	Gene	Treg|compound|START_ENTITY islet|dobj|Treg islet|nsubj|increases increases|compound|END_ENTITY	b-cell-specific IL-2 therapy increases islet Foxp3 + Treg and suppresses type 1 diabetes in NOD mice .
25548225	0	Foxp3	99,104	IL-2	124,128	Foxp3	IL-2	50943	3558	Gene	Gene	START_ENTITY|nmod|Promoter Promoter|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
26886923	0	Foxp3	54,59	IL-2	99,103	Foxp3	IL-2	50943	3558	Gene	Gene	Cells|compound|START_ENTITY Analysis|nmod|Cells Analysis|nmod|END_ENTITY	Comparative Analysis of Protocols to Induce Human CD4 + Foxp3 + Regulatory T Cells by Combinations of IL-2 , TGF-beta , Retinoic_Acid , Rapamycin and Butyrate .
17675505	0	Foxp3	22,27	IL-4	69,73	Foxp3	IL-4	20371(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY reveal|nmod|cells reveal|nsubj|mice mice|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
18490709	0	Foxp3	14,19	IL-6	114,118	Foxp3	IL-6	50943	3569	Gene	Gene	CD25|compound|START_ENTITY +|nsubj|CD25 +|ccomp|resistant resistant|nmod|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
19841165	0	Foxp3	74,79	IL-7	108,112	Foxp3	IL-7	20371(Tax:10090)	16196(Tax:10090)	Gene	Gene	differentiation|nmod|START_ENTITY autoimmune_disease|nmod|differentiation regulation|nmod|autoimmune_disease +|nsubj|regulation +|nmod|END_ENTITY	Thymic regulation of autoimmune_disease by accelerated differentiation of Foxp3 + regulatory T cells through IL-7 signaling pathway .
20693259	0	Foxp3	16,21	IL-7	45,49	Foxp3	IL-7	50943	3574	Gene	Gene	cells|compound|START_ENTITY cells|ccomp|lack lack|dobj|receptor receptor|compound|END_ENTITY	Numbers of CD25 + Foxp3 + T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients .
22593613	0	Foxp3	43,48	IL-7	11,15	Foxp3	IL-7	20371(Tax:10090)	16196(Tax:10090)	Gene	Gene	requirement|nmod|START_ENTITY requirement|compound|END_ENTITY	An in vivo IL-7 requirement for peripheral Foxp3 + regulatory T cell homeostasis .
18566388	0	Foxp3	34,39	IL-7R	15,20	Foxp3	IL-7R	20371(Tax:10090)	16197(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
19380824	0	Foxp3	27,32	IRAK-1	79,85	Foxp3	IRAK-1	20371(Tax:10090)	16179(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1 .
18278048	0	Foxp3	74,79	Itch	24,28	Foxp3	Itch	20371(Tax:10090)	16396(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 .
20108139	0	Foxp3	0,5	Itch	86,90	Foxp3	Itch	50943	83737	Gene	Gene	cells|amod|START_ENTITY cells|dep|regulation regulation|nmod|END_ENTITY	Foxp3 positive regulatory T cells : a functional regulation by the E3 ubiquitin ligase Itch .
18025186	0	Foxp3	70,75	Keratinocyte_growth_factor	0,26	Foxp3	Keratinocyte growth factor	20371(Tax:10090)	14178(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells induces|dobj|expansion induces|nsubj|END_ENTITY	Keratinocyte_growth_factor induces expansion of murine peripheral CD4 + Foxp3 + regulatory T cells and increases their thymic output .
21124798	0	Foxp3	74,79	LAP	22,25	Foxp3	LAP	20371(Tax:10090)	219103(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY cells|nmod|induction expression|nmod|cells expression|compound|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
24064667	0	Foxp3	124,129	LAP	48,51	Foxp3	LAP	50943	7040	Gene	Gene	cells|amod|START_ENTITY exhibit|nmod|cells exhibit|nsubj|cells cells|compound|END_ENTITY	Highly prevalent colorectal_cancer-infiltrating LAP Foxp3 T cells exhibit more potent immunosuppressive activity than Foxp3 regulatory T cells .
24064667	0	Foxp3	55,60	LAP	48,51	Foxp3	LAP	50943	7040	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Highly prevalent colorectal_cancer-infiltrating LAP Foxp3 T cells exhibit more potent immunosuppressive activity than Foxp3 regulatory T cells .
26004193	0	Foxp3	63,68	LAP	69,72	Foxp3	LAP	20371(Tax:10090)	13708(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vitamin_A supplementation leads to increases in regulatory CD4 + Foxp3 + LAP + T cells in mice .
18550850	0	Foxp3	43,48	Notch1	0,6	Foxp3	Notch1	50943	4851	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells .
21468021	0	Foxp3	42,47	Nr4a2	28,33	Foxp3	Nr4a2	50943	4929	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4 + T cells .
17641007	0	Foxp3	99,104	OX40	14,18	Foxp3	OX40	50943	7293	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|nsubj|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
23977081	0	Foxp3	82,87	PARP-1	0,6	Foxp3	PARP-1	20371(Tax:10090)	11545(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3 .
19229109	0	Foxp3	36,41	PD-L1	0,5	Foxp3	PD-L1	50943	29126	Gene	Gene	Tregs|compound|START_ENTITY regulates|dobj|Tregs regulates|nsubj|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
23769057	0	Foxp3	54,59	PD-L1	0,5	Foxp3	PD-L1	20371(Tax:10090)	60533(Tax:10090)	Gene	Gene	critical|nmod|START_ENTITY critical|nsubj|signal signal|compound|END_ENTITY	PD-L1 signal on liver dendritic cells is critical for Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Treg and liver tolerance induction in mice .
26615520	0	Foxp3	89,94	PD-L1	121,126	Foxp3	PD-L1	50943	29126	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Human umbilical vein endothelial cells promote the inhibitory activation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via PD-L1 .
18509048	0	Foxp3	35,40	PI3K	56,60	Foxp3	PI3K	50943	5290	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	T cell receptor signaling controls Foxp3 expression via PI3K , Akt , and mTOR .
21949025	0	Foxp3	83,88	ST2L	77,81	Foxp3	ST2L	20371(Tax:10090)	17082(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	IL-33 expands suppressive CD11b + Gr-1 -LRB- int -RRB- and regulatory T cells , including ST2L + Foxp3 + cells , and mediates regulatory T cell-dependent promotion of cardiac allograft survival .
17182565	0	Foxp3	81,86	STAT5	29,34	Foxp3	STAT5	20371(Tax:10090)	20850(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY development|nmod|cells required|nmod|development required|nsubjpass|activation activation|compound|END_ENTITY	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells .
24298014	0	Foxp3	15,20	Stat5	67,72	Foxp3	Stat5	50943	6776	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	TGF-b-mediated Foxp3 gene expression is cooperatively regulated by Stat5 , Creb , and AP-1 through CNS2 .
25219397	0	Foxp3	35,40	T-bet	0,5	Foxp3	T-bet	20371(Tax:10090)	57765(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY differentiation|nmod|cells regulates|dobj|differentiation regulates|nsubj|END_ENTITY	T-bet regulates differentiation of Foxp3 -LRB- + -RRB- regulatory T cells in programmed_cell_death-1-deficient mice .
25741342	0	Foxp3	20,25	T-bet	0,5	Foxp3	T-bet	20371(Tax:10090)	57765(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	T-bet Expression by Foxp3 -LRB- + -RRB- T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune_Disease or Colitis .
18810612	0	Foxp3	37,42	TGF-Beta	8,16	Foxp3	TGF-Beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function .
20876311	0	Foxp3	42,47	TGF-b	95,100	Foxp3	TGF-b	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nmod|pathway pathway|amod|END_ENTITY	Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-b pathway .
21057085	0	Foxp3	128,133	TGF-b	74,79	Foxp3	TGF-b	50943	7040	Gene	Gene	cells|nmod|START_ENTITY +|nsubj|cells agonists|parataxis|+ agonists|nmod|END_ENTITY	Peroxisome proliferator-activated receptor a and y agonists together with TGF-b convert human CD4 + CD25 - T cells into functional Foxp3 + regulatory T cells .
21124798	0	Foxp3	74,79	TGF-b	0,5	Foxp3	TGF-b	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY cells|nmod|induction expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
21839859	0	Foxp3	5,10	TGF-b	42,47	Foxp3	TGF-b	317382(Tax:10116)	59086(Tax:10116)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|acl|induced induced|nmod|bronchiolitis bronchiolitis|amod|END_ENTITY	CD4 + Foxp3 + regulatory T cells induced by TGF-b , IL-2 and all-trans_retinoic_acid attenuate obliterative bronchiolitis in rat trachea transplantation .
22156591	0	Foxp3	82,87	TGF-b	24,29	Foxp3	TGF-b	50943	7040	Gene	Gene	converts|nmod|START_ENTITY converts|nsubj|Rapamycin Rapamycin|nmod|END_ENTITY	Rapamycin combined with TGF-b converts human invariant NKT cells into suppressive Foxp3 + regulatory cells .
25132806	0	Foxp3	30,35	TGF-b	38,43	Foxp3	TGF-b	50943	7040	Gene	Gene	percentage|nmod|START_ENTITY END_ENTITY|nsubj|percentage	Decreased percentage of CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- TGF-b -LRB- + -RRB- and increased percentage of CD4 -LRB- + -RRB- IL-17 -LRB- + -RRB- cells in bronchoalveolar lavage of asthmatics .
27075967	0	Foxp3	31,36	TGF-b	89,94	Foxp3	TGF-b	50943	7040	Gene	Gene	cells|nsubj|START_ENTITY cells|nmod|binding binding|nmod|END_ENTITY	Human macrophages induce CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via binding and re-release of TGF-b .
21528082	0	Foxp3	38,43	TGF-b1	90,96	Foxp3	TGF-b1	50943	7040	Gene	Gene	cells|amod|START_ENTITY induce|dobj|cells induce|nmod|production production|nmod|END_ENTITY	Gastric_cancer cells induce human CD4 + Foxp3 + regulatory T cells through the production of TGF-b1 .
21779356	0	Foxp3	41,46	TGF-b1	15,21	Foxp3	TGF-b1	50943	7040	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	IL-1b promotes TGF-b1 and IL-2 dependent Foxp3 expression in regulatory T cells .
22161558	0	Foxp3	74,79	TGF-b1	125,131	Foxp3	TGF-b1	50943	7040	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nmod|pathway pathway|compound|END_ENTITY	Hypothesis : human umbilical cord blood-derived stromal cells regulate the Foxp3 expression of regulatory T cells through the TGF-b1 / Smad3 pathway .
22270834	0	Foxp3	121,126	TGF-b1	21,27	Foxp3	TGF-b1	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Dendritic cells with TGF-b1 and IL-2 differentiate naive CD4 + T cells into alloantigen-specific and allograft protective Foxp3 + regulatory T cells .
22749982	0	Foxp3	54,59	TGF-b1	37,43	Foxp3	TGF-b1	50943	7040	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|CD152 CD152|appos|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
23361571	0	Foxp3	74,79	TGF-b1	0,6	Foxp3	TGF-b1	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b1 secreted by hepatocellular_carcinoma induces the expression of the Foxp3 gene and suppresses antitumor immunity in the tumor microenvironment .
24668348	0	Foxp3	57,62	TGF-b1	130,136	Foxp3	TGF-b1	50943	7040	Gene	Gene	suppresses|amod|START_ENTITY T|nsubj|suppresses T|dobj|response response|nmod|END_ENTITY	Human hepatocellular_carcinoma-infiltrating CD4 CD69 Foxp3 regulatory T cell suppresses T cell response via membrane-bound TGF-b1 .
14676299	0	Foxp3	127,132	TGF-beta	84,92	Foxp3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15100250	0	Foxp3	83,88	TGF-beta	14,22	Foxp3	TGF-beta	50943	7040	Gene	Gene	induction|amod|START_ENTITY cells|nmod|induction phenotype|dep|cells induces|dobj|phenotype induces|nsubj|END_ENTITY	Cutting edge : TGF-beta induces a regulatory phenotype in CD4 + CD25 - T cells through Foxp3 induction and down-regulation of Smad7 .
15367216	0	Foxp3	17,22	TGF-beta	0,8	Foxp3	TGF-beta	50943	7040	Gene	Gene	cells|amod|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
17277105	0	Foxp3	72,77	TGF-beta	22,30	Foxp3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells CD25|dep|cells convert|dobj|CD25 essential|xcomp|convert essential|nmod|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17548603	0	Foxp3	34,39	TGF-beta	62,70	Foxp3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY induced|nsubj|analysis induced|nmod|END_ENTITY	A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta .
17641007	0	Foxp3	99,104	TGF-beta	28,36	Foxp3	TGF-beta	50943	7040	Gene	Gene	cells|compound|START_ENTITY inhibits|nmod|cells inhibits|dobj|conversion conversion|amod|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17688698	0	Foxp3	68,73	TGF-beta	11,19	Foxp3	TGF-beta	50943	7040	Gene	Gene	induction|amod|START_ENTITY key|nmod|induction key|nsubj|activation activation|amod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
17695668	0	Foxp3	34,39	TGF-beta	62,70	Foxp3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY induced|nsubj|analysis induced|nmod|END_ENTITY	A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta .
18029395	0	Foxp3	120,125	TGF-beta	19,27	Foxp3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY mice|nmod|cells diabetes|nmod|mice reversal|nmod|diabetes roles|dep|reversal roles|nmod|END_ENTITY	Essential roles of TGF-beta in anti-CD3 antibody therapy : reversal of diabetes in nonobese diabetic mice independent of Foxp3 + CD4 + regulatory T cells .
18395859	0	Foxp3	58,63	TGF-beta	29,37	Foxp3	TGF-beta	50943	7040	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function .
19307989	0	Foxp3	50,55	TGF-beta	14,22	Foxp3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	conversion|nmod|START_ENTITY conversion|amod|END_ENTITY	Tumor-derived TGF-beta mediates conversion of CD4 + Foxp3 + regulatory T cells in a murine model of pancreas_cancer .
19648226	0	Foxp3	24,29	TGF-beta	0,8	Foxp3	TGF-beta	50943	7040	Gene	Gene	START_ENTITY|amod|adaptive adaptive|dep|END_ENTITY	TGF-beta and ` adaptive ' Foxp3 -LRB- + -RRB- regulatory T cells .
19943263	0	Foxp3	71,76	TGF-beta	22,30	Foxp3	TGF-beta	50943	7040	Gene	Gene	Treg|compound|START_ENTITY induction|nmod|Treg effect|nmod|induction effect|nmod|members members|amod|END_ENTITY	Synergistic effect of TGF-beta superfamily members on the induction of Foxp3 + Treg .
20639482	0	Foxp3	29,34	TGF-beta	67,75	Foxp3	TGF-beta	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY +|nsubj|Identification +|dobj|cells cells|acl|induced induced|nmod|END_ENTITY	Identification of regulatory Foxp3 + invariant NKT cells induced by TGF-beta .
16918480	0	Foxp3	14,19	TGF-beta1	4,13	Foxp3	TGF-beta1	50943	7040	Gene	Gene	axis|amod|START_ENTITY END_ENTITY|dep|axis	The TGF-beta1 / Foxp3 regulatory axis in immune self-tolerance : implications for health and disease .
17307871	0	Foxp3	91,96	TGF-beta1	21,30	Foxp3	TGF-beta1	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|cells cells|dep|cells cells|nmod|CD25 CD25|amod|naive naive|nmod:npmod|differentiate differentiate|nummod|END_ENTITY	Dendritic cells with TGF-beta1 differentiate naive CD4 + CD25 - T cells into islet-protective Foxp3 + regulatory T cells .
17475784	0	Foxp3	20,25	TGF-beta1	0,9	Foxp3	TGF-beta1	50943	7040	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4 + T cell subsets .
19079658	0	Foxp3	61,66	TGF-beta1	21,30	Foxp3	TGF-beta1	50943	7040	Gene	Gene	Cells|compound|START_ENTITY Role|nmod|Cells Role|nmod|END_ENTITY	The Critical Role of TGF-beta1 in the Development of Induced Foxp3 + Regulatory T Cells .
20081874	0	Foxp3	120,125	TGF-beta1	0,9	Foxp3	TGF-beta1	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	inflammatory_bowel_disease|nmod|START_ENTITY cells|amod|inflammatory_bowel_disease development|nmod|cells delay|dobj|development delay|ccomp|gene-modified gene-modified|advmod|END_ENTITY	TGF-beta1 gene-modified , immature dendritic cells delay the development of inflammatory_bowel_disease by inducing CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
17911604	0	Foxp3	64,69	TGF-beta_1	85,95	Foxp3	TGF-beta 1	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	+|compound|START_ENTITY induces|dobj|+ induces|parataxis|adaptive adaptive|nsubj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
25790134	0	Foxp3	55,60	TLR-2	0,5	Foxp3	TLR-2	20371(Tax:10090)	24088(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
23490285	0	Foxp3	37,42	TLR9	24,28	Foxp3	TLR9	50943	54106	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	DNA methylation impairs TLR9 induced Foxp3 expression by attenuating IRF-7 binding activity in fulminant type 1 diabetes .
22105853	0	Foxp3	50,55	TNFR2	0,5	Foxp3	TNFR2	20371(Tax:10090)	21937(Tax:10090)	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|END_ENTITY	TNFR2 on non-haematopoietic cells is required for Foxp3 + Treg-cell function and disease suppression in EAE .
23277487	0	Foxp3	51,56	TNFR2	0,5	Foxp3	TNFR2	20371(Tax:10090)	21938(Tax:10090)	Gene	Gene	phenotype|compound|START_ENTITY stabilization|nmod|phenotype critical|nmod|stabilization critical|nsubj|END_ENTITY	TNFR2 is critical for the stabilization of the CD4 + Foxp3 + regulatory T. cell phenotype in the inflammatory environment .
23734780	0	Foxp3	43,48	Th1	117,120	Foxp3	Th1	20371(Tax:10090)	57314(Tax:10090)	Gene	Gene	population|compound|START_ENTITY generate|dobj|population generate|nmod|process process|nmod|cells cells|amod|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
22576743	0	Foxp3	0,5	Toll-like_receptor_4	47,67	Foxp3	Toll-like receptor 4	50943	7099	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Foxp3 expression in A549 cells is regulated by Toll-like_receptor_4 through nuclear factor-kB .
19995950	0	Foxp3	48,53	c-Rel	0,5	Foxp3	c-Rel	20371(Tax:10090)	19696(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells required|nmod|development required|nsubjpass|END_ENTITY	c-Rel is required for the development of thymic Foxp3 + CD4 regulatory T cells .
20049877	0	Foxp3	38,43	c-Rel	0,5	Foxp3	c-Rel	50943	5966	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells crucial|nmod|induction crucial|nsubj|END_ENTITY	c-Rel is crucial for the induction of Foxp3 -LRB- + -RRB- regulatory CD4 -LRB- + -RRB- T cells but not T -LRB- H -RRB- 17 cells .
20064450	0	Foxp3	15,20	c-Rel	60,65	Foxp3	c-Rel	20371(Tax:10090)	19696(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Development|nmod|cells driven|nsubjpass|Development driven|nmod|enhanceosome enhanceosome|amod|END_ENTITY	Development of Foxp3 -LRB- + -RRB- regulatory t cells is driven by the c-Rel enhanceosome .
21490927	0	Foxp3	0,5	c-Rel	21,26	Foxp3	c-Rel	50943	5966	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Foxp3 interacts with c-Rel to mediate NF-kB repression .
22066012	0	Foxp3	68,73	c-Rel	0,5	Foxp3	c-Rel	20371(Tax:10090)	19696(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY development|nmod|cells controls|nmod|development controls|nsubj|END_ENTITY	c-Rel controls multiple discrete steps in the thymic development of Foxp3 + CD4 regulatory T cells .
15640801	0	Foxp3	52,57	interleukin_2	124,137	Foxp3	interleukin 2	50943	3558	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin_2 .
17967941	0	Foxp3	76,81	mammalian_target_of_rapamycin	23,52	Foxp3	mammalian target of rapamycin	50943	2475	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
18462346	0	Foxp3	69,74	prion_protein	13,26	Foxp3	prion protein	20371(Tax:10090)	19122(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expressed|nmod|cells expressed|nsubjpass|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
20382886	0	Foxp3	65,70	programmed_death-1	107,125	Foxp3	programmed death-1	20371(Tax:10090)	18566(Tax:10090)	Gene	Gene	+|compound|START_ENTITY function|nmod|+ augment|iobj|function augment|parataxis|involvement involvement|nmod|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
16835220	0	Foxq1	41,46	Hoxc13	113,119	Foxq1	Hoxc13	15220(Tax:10090)	15422(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation .
7559654	0	Fpr3	23,27	Ptp1	109,113	Fpr3	Ptp1	854901(Tax:4932)	851368(Tax:4932)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1 .
23904356	0	Fra	0,3	activator_protein_1	35,54	Fra	activator protein 1	8061	2354	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Fra , Fra away : the complex role of activator_protein_1 in liver_injury .
11756554	0	Fra-1	19,24	AP-1	54,58	Fra-1	AP-1	14283(Tax:10090)	16476(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently .
25339983	0	Fra-1	0,5	MMP-1	47,52	Fra-1	MMP-1	8061	4312	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Fra-1 regulation of Matrix_Metallopeptidase-1 -LRB- MMP-1 -RRB- in metastatic variants of MDA-MB-231 breast_cancer cells .
25339983	0	Fra-1	0,5	Matrix_Metallopeptidase-1	20,45	Fra-1	Matrix Metallopeptidase-1	8061	4312	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Fra-1 regulation of Matrix_Metallopeptidase-1 -LRB- MMP-1 -RRB- in metastatic variants of MDA-MB-231 breast_cancer cells .
17882273	0	Fra-1	62,67	involucrin	32,42	Fra-1	involucrin	8061	3713	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Synergistic activation of human involucrin gene expression by Fra-1 and p300 -- evidence for the presence of a multiprotein complex .
7759510	0	Fra-1	21,26	involucrin	59,69	Fra-1	involucrin	8061	3713	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|transcription transcription|compound|END_ENTITY	Fos-related_antigen -LRB- Fra-1 -RRB- , junB , and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol_ester effects on promoter activity .
18098284	0	Fra-1	0,5	vimentin	16,24	Fra-1	vimentin	8061	7431	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon_carcinoma cells .
10987819	0	Fra-2	141,146	AP-1	30,34	Fra-2	AP-1	25446(Tax:10116)	24516(Tax:10116)	Gene	Gene	depends|nmod|START_ENTITY depends|nsubj|activity activity|nmod|END_ENTITY	Circadian binding activity of AP-1 , a regulator of the arylalkylamine_N-acetyltransferase gene in the rat pineal gland , depends on circadian Fra-2 , c-Jun , and Jun-D expression and is regulated by the clock 's zeitgebers .
20837772	0	Fra-2	0,5	AP-1	6,10	Fra-2	AP-1	14284(Tax:10090)	16476(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	Fra-2 / AP-1 controls bone formation by regulating osteoblast differentiation and collagen production .
24464219	0	Fra-2	0,5	AP-1	6,10	Fra-2	AP-1	14284(Tax:10090)	16476(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	Fra-2 / AP-1 controls adipocyte differentiation and survival by regulating PPARy and hypoxia .
22177089	0	Fractalkine	0,11	CX3CL1	13,19	Fractalkine	CX3CL1	6376	6376	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Fractalkine -LRB- CX3CL1 -RRB- levels in patients with Beh et 's disease and neuro-Beh et 's disease .
26586708	0	Fractalkine	32,43	CX3CL1	25,31	Fractalkine	CX3CL1	6376	6376	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Elevated Local and Serum CX3CL1 -LRB- Fractalkine -RRB- Expression and Its Association with Disease Severity in Patients with Psoriasis .
17885215	0	Fractalkine	0,11	CX3CR1	87,93	Fractalkine	CX3CR1	6376	1524	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|END_ENTITY	Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway .
12569179	0	Fractalkine	0,11	FRK	13,16	Fractalkine	FRK	6376	6376	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Fractalkine -LRB- FRK -RRB- levels in amniotic fluid and its production during pregnancy .
11777952	0	Fractalkine	0,11	IFN-gamma	63,72	Fractalkine	IFN-gamma	6376	3458	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity .
18003857	0	Fractalkine_receptor	0,20	CX3CR1	22,28	Fractalkine receptor	CX3CR1	13051(Tax:10090)	13051(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Fractalkine_receptor -LRB- CX3CR1 -RRB- inhibition is protective against ischemic acute_renal_failure in mice .
25221380	0	Fractalkine_receptor	25,45	CX3CR1	46,52	Fractalkine receptor	CX3CR1	1524	1524	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Two polymorphisms in the Fractalkine_receptor CX3CR1 gene influence the development of atherosclerosis : a meta-analysis .
20606729	0	Fragile_Histidine_Triad	66,89	FHIT	91,95	Fragile Histidine Triad	FHIT	2272	2272	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the promoter methylation and protein expression of Fragile_Histidine_Triad -LRB- FHIT -RRB- gene with the progression of differentiated_thyroid_carcinoma .
19452299	0	Fragile_histidine_triad	0,23	FHIT	25,29	Fragile histidine triad	FHIT	2272	2272	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fragile_histidine_triad -LRB- FHIT -RRB- gene and its association with p53 protein expression in the progression of gall_bladder_cancer .
14634209	0	Frap	0,4	Pctr2	101,106	Frap	Pctr2	56717(Tax:10090)	104290(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Frap , FKBP12_rapamycin-associated_protein , is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene .
22031191	0	Fras-1-related_extracellular_matrix_protein	107,150	FREM2	152,157	Fras-1-related extracellular matrix protein	FREM2	341640	341640	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the Fras-1-related_extracellular_matrix_protein -LRB- FREM2 -RRB- gene .
12556519	0	Frat-1	57,63	Casein_kinase_I_epsilon	0,23	Frat-1	Casein kinase I epsilon	10023	102800317	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Casein_kinase_I_epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin .
26339677	0	Frataxin	0,8	Friedreich_ataxia	40,57	Frataxin	Friedreich ataxia	2395	2395	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Frataxin levels in peripheral tissue in Friedreich_ataxia .
21155902	0	Freud-2	0,7	CC2D1B	8,14	Freud-2	CC2D1B	319965(Tax:10090)	319965(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Freud-2 / CC2D1B mediates dual repression of the serotonin-1A receptor gene .
24816001	0	Friedreich_ataxia	9,26	FXN	44,47	Friedreich ataxia	FXN	2395	2395	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Atypical Friedreich_ataxia in patients with FXN p.R165P point mutation or comorbid hemochromatosis .
26339677	0	Friedreich_ataxia	40,57	Frataxin	0,8	Friedreich ataxia	Frataxin	2395	2395	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Frataxin levels in peripheral tissue in Friedreich_ataxia .
17498922	0	Friedreich_ataxia	67,84	GAA	36,39	Friedreich ataxia	GAA	2395	2548	Gene	Gene	sequence|nmod|START_ENTITY sequence|compound|END_ENTITY	Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich_ataxia progresses throughout life .
15970401	0	Friedreich_ataxia	27,44	IRP1	10,14	Friedreich ataxia	IRP1	2395	48	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Increased IRP1 activity in Friedreich_ataxia .
15507435	0	Friend_of_GATA	17,31	FOG	33,36	Friend of GATA	FOG	161882	161882	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	The N termini of Friend_of_GATA -LRB- FOG -RRB- proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors .
11743650	0	Frizzled-10	17,28	FZD10	30,35	Frizzled-10	FZD10	11211	11211	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of Frizzled-10 -LRB- FZD10 -RRB- by beta-estradiol in MCF-7 cells and by retinoic_acid in NT2 cells .
20530549	0	Frizzled-5	0,10	Wnt7a	50,55	Frizzled-5	Wnt7a	14367(Tax:10090)	22421(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Frizzled-5 , a receptor for the synaptic organizer Wnt7a , regulates activity-mediated synaptogenesis .
11408930	0	Frizzled-7	17,27	FZD7	29,33	Frizzled-7	FZD7	8324	8324	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of Frizzled-7 -LRB- FZD7 -RRB- in human gastric_cancer .
12138115	0	Frizzled-9	0,10	Wnt-2	27,32	Frizzled-9	Wnt-2	266608(Tax:10116)	7472	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta _ - catenin signaling .
14507768	0	Frizzled_4	0,10	FZD4	17,21	Frizzled 4	FZD4	8322	8322	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frizzled_4 gene -LRB- FZD4 -RRB- mutations in patients with familial_exudative_vitreoretinopathy with variable expressivity .
18809723	0	Frizzled_7	20,30	Ryk	0,3	Frizzled 7	Ryk	378787(Tax:8355)	734495(Tax:8355)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Ryk cooperates with Frizzled_7 to promote Wnt11-mediated endocytosis and is essential for Xenopus_laevis convergent extension movements .
16707163	0	Frizzled_homolog_3	51,69	FZD3	76,80	Frizzled homolog 3	FZD3	7976	7976	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of genetic association between human Frizzled_homolog_3 gene -LRB- FZD3 -RRB- and schizophrenia : results in a Korean population and evidence from meta-analysis .
11941372	0	Frodo	0,5	Dishevelled	21,32	Frodo	Dishevelled	398315(Tax:8355)	399301(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Frodo interacts with Dishevelled to transduce Wnt signals .
17084360	0	Frodo	0,5	Dishevelled	12,23	Frodo	Dishevelled	398315(Tax:8355)	399301(Tax:8355)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Frodo links Dishevelled to the p120-catenin/Kaiso pathway : distinct catenin subfamilies promote Wnt signals .
20406475	0	Fry	15,18	Trc	42,45	Fry	Trc	39122(Tax:7227)	40165(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The Drosophila Fry protein interacts with Trc and is highly mobile in vivo .
9118219	0	Frzb	0,4	Wnt-8	80,85	Frzb	Wnt-8	734982(Tax:8355)	397970(Tax:8355)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Frzb , a secreted protein expressed in the Spemann organizer , binds and inhibits Wnt-8 .
15649459	0	Frzb	0,4	beta-catenin	31,43	Frzb	beta-catenin	395545(Tax:9031)	395964(Tax:9031)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development .
22116805	0	Fshr	46,50	aryl_hydrocarbon_receptor	4,29	Fshr	aryl hydrocarbon receptor	14309(Tax:10090)	11622(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor regulates mouse Fshr promoter activity through an e-box binding site .
9811568	0	Fsrg1	33,38	female_sterile_homeotic	105,128	Fsrg1	female sterile homeotic	14312(Tax:10090)	31722(Tax:7227)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Expression and potential role of Fsrg1 , a murine bromodomain-containing homologue of the Drosophila gene female_sterile_homeotic .
17030984	0	Fstl1	14,19	MyoD	0,4	Fstl1	MyoD	11167	4654	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206 .
24482432	0	FtSH4	58,63	peroxidase	78,88	FtSH4	peroxidase	817154(Tax:3702)	816773(Tax:3702)	Gene	Gene	accumulation|amod|START_ENTITY accumulation|compound|END_ENTITY	Perturbation of auxin homeostasis caused by mitochondrial FtSH4 gene-mediated peroxidase accumulation regulates arabidopsis architecture .
9020364	0	Ftz	89,92	Ftz-F1	29,35	Ftz	Ftz-F1	40834(Tax:7227)	40045(Tax:7227)	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz .
9020364	0	Ftz-F1	29,35	Ftz	89,92	Ftz-F1	Ftz	40045(Tax:7227)	40834(Tax:7227)	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz .
10704877	0	Ftz-F1	36,42	ff1b	54,58	Ftz-F1	ff1b	30749(Tax:7955)	83916(Tax:7955)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Developmental expression of a novel Ftz-F1 homologue , ff1b -LRB- NR5A4 -RRB- , in the zebrafish Danio_rerio .
8666674	0	FucT-VII	23,31	E-selectin	42,52	FucT-VII	E-selectin	2529	6401	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|amod|END_ENTITY	The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells .
20570966	0	Fucosyltransferase_2	0,20	FUT2	22,26	Fucosyltransferase 2	FUT2	2524	2524	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Fucosyltransferase_2 -LRB- FUT2 -RRB- non-secretor status is associated with Crohn 's _ disease .
22799384	0	Fucosyltransferase_IV	0,21	MMP-12	45,51	Fucosyltransferase IV	MMP-12	2526	4321	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Fucosyltransferase_IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2 , p38 and NF-kB pathways in A431 cells .
18772886	0	Furin	16,21	Cripto	0,6	Furin	Cripto	5045	6998	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation .
25562172	0	Fus	72,75	MiR-378	0,7	Fus	MiR-378	233908(Tax:10090)	723889(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Promotes|nmod|Expression Promotes|nsubj|END_ENTITY	MiR-378 Promotes the Migration of Liver_Cancer Cells by Down-Regulating Fus Expression .
26681517	0	Fus2p	30,35	Rvs161p	52,59	Fus2p	Rvs161p	855272(Tax:4932)	850367(Tax:4932)	Gene	Gene	Domain|nmod|START_ENTITY Required|nsubjpass|Domain Required|nmod|Interaction Interaction|compound|END_ENTITY	An Amphiphysin-like Domain in Fus2p is Required for Rvs161p Interaction and Cortical Localization .
9566960	0	Fus2p	23,28	Rvs161p	0,7	Fus2p	Rvs161p	855272(Tax:4932)	850367(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces_cerevisiae .
21777610	0	Fused_Toes_Homolog	99,117	FTS	94,97	Fused Toes Homolog	FTS	64400	64400	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Phosphorylation of threonine 190 is essential for nuclear localization and endocytosis of the FTS -LRB- Fused_Toes_Homolog -RRB- protein .
24971934	0	Fused_Toes_Homolog	26,44	FTS	46,49	Fused Toes Homolog	FTS	64400	64400	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	EGF-induced expression of Fused_Toes_Homolog -LRB- FTS -RRB- facilitates epithelial-mesenchymal transition and promotes cell migration in ME180 cervical cancer cells .
23867462	0	Fused_in_sarcoma	0,16	FUS	18,21	Fused in sarcoma	FUS	233908(Tax:10090)	233908(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Fused_in_sarcoma -LRB- FUS -RRB- protein lacking nuclear localization signal -LRB- NLS -RRB- and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic_mice .
19179362	0	Fut8	15,19	vascular_endothelial_growth_factor_receptor-2	42,87	Fut8	vascular endothelial growth factor receptor-2	53618(Tax:10090)	16542(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Requirement of Fut8 for the expression of vascular_endothelial_growth_factor_receptor-2 : a new mechanism for the emphysema-like changes observed in Fut8-deficient mice .
11733059	0	Futsch	62,68	MAP1B	48,53	Futsch	MAP1B	5740544(Tax:7227)	5740544(Tax:7227)	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function .
26607136	0	Fxa	56,59	TFPI	63,67	Fxa	TFPI	2159	7035	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of exosite binding modulators in the inhibition of Fxa by TFPI .
15848169	0	Fyb	21,24	Fyn	0,3	Fyb	Fyn	2533	2534	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Fyn binding protein , Fyb , interacts with mammalian actin binding protein , mAbp1 .
8892616	0	Fyn	85,88	Beta1	0,5	Fyn	Beta1	2534	3779	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Beta1 integrin-mediated activation of focal adhesion kinase and its association with Fyn and Zap-70 in human NK cells .
19955046	0	Fyn	0,3	CD4	27,30	Fyn	CD4	2534	920	Gene	Gene	expression|nsubj|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Fyn and CD70 expression in CD4 + T cells from patients with systemic_lupus_erythematosus .
9890970	0	Fyn	0,3	Cbl	20,23	Fyn	Cbl	25150(Tax:10116)	500985(Tax:10116)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl , a binding site for phosphatidylinositol 3-kinase .
11468287	0	Fyn	13,16	FAK	38,41	Fyn	FAK	14360(Tax:10090)	14083(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Dual role of Fyn in the regulation of FAK +6,7 by cannabinoids in hippocampus .
15848169	0	Fyn	0,3	Fyb	21,24	Fyn	Fyb	2534	2533	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Fyn binding protein , Fyb , interacts with mammalian actin binding protein , mAbp1 .
21642356	0	Fyn	0,3	HnRNPA2B1	13,22	Fyn	HnRNPA2B1	2534	3181	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic_cancer .
10551884	0	Fyn	87,90	Jak2	23,27	Fyn	Jak2	2534	3717	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	A catalytically active Jak2 is required for the angiotensin_II-dependent activation of Fyn .
12732664	0	Fyn	14,17	Lck	53,56	Fyn	Lck	2534	3932	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Fyn through translocation of activated Lck into lipid rafts .
18660530	0	Fyn	14,17	Lck	86,89	Fyn	Lck	14360(Tax:10090)	16818(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY requires|nsubj|activation requires|xcomp|targeting targeting|nmod|END_ENTITY	Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts .
8934569	0	Fyn	0,3	Lck	33,36	Fyn	Lck	14360(Tax:10090)	16818(Tax:10090)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	Fyn can partially substitute for Lck in T lymphocyte development .
11546790	0	Fyn	11,14	MAP-2c	18,24	Fyn	MAP-2c	2534	4133	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Fyn to MAP-2c through an SH3 binding domain .
15536091	0	Fyn	0,3	MAP-2c	25,31	Fyn	MAP-2c	2534	4133	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Fyn phosphorylates human MAP-2c on tyrosine 67 .
22057277	0	Fyn	22,25	Mrp2	59,63	Fyn	Mrp2	25150(Tax:10116)	25303(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane .
25565773	0	Fyn	92,95	NR2B	101,105	Fyn	NR2B	25150(Tax:10116)	24410(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY tyrosine|dobj|phosphorylation tyrosine|nmod|END_ENTITY	Postsynaptic_density_protein_95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced_dyskinesia rat models .
16966330	0	Fyn	92,95	Nck	70,73	Fyn	Nck	2534	4690	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF .
15713745	0	Fyn	131,134	Pigment_epithelium-derived_factor	0,33	Fyn	Pigment epithelium-derived factor	2534	57104	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Pigment_epithelium-derived_factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn .
16339530	0	Fyn	45,48	Protein_tyrosine_phosphatase_alpha	0,34	Fyn	Protein tyrosine phosphatase alpha	14360(Tax:10090)	19262(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Protein_tyrosine_phosphatase_alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts .
22387224	0	Fyn	0,3	RANKL	92,97	Fyn	RANKL	2534	8600	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Fyn positively regulates the activation of DAP12 and FcRy-mediated costimulatory signals by RANKL during osteoclastogenesis .
7517401	0	Fyn	21,24	Raf-1	0,5	Fyn	Raf-1	2534	5894	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner .
10212213	0	Fyn	0,3	SHP-2	85,90	Fyn	SHP-2	475032(Tax:9615)	477488(Tax:9615)	Gene	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells .
22802969	0	Fyn	15,18	Shp2	0,4	Fyn	Shp2	25150(Tax:10116)	25622(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Shp2 activates Fyn and Ras to regulate RBL-2H3 mast cell activation following Fc RI_aggregation .
16547257	0	Fyn	8,11	TCR	73,76	Fyn	TCR	14360(Tax:10090)	328483(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR .
7722293	0	Fyn	53,56	TCR	138,141	Fyn	TCR	14360(Tax:10090)	328483(Tax:10090)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1 .
16860569	0	Fyn	11,14	Trk	18,21	Fyn	Trk	2534	4914	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling .
17579091	0	Fyn	73,76	Unc119	0,6	Fyn	Unc119	2534	9094	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway .
18701695	0	Fyn	117,120	WAVE2	24,29	Fyn	WAVE2	2534	10163	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn .
11162638	0	Fyn	10,13	alpha-synuclein	29,44	Fyn	alpha-synuclein	2534	6622	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125 .
18354028	0	Fyn	76,79	beta1	26,31	Fyn	beta1	14360(Tax:10090)	15129(Tax:10090)	Gene	Gene	kinase|nsubj|START_ENTITY requires|xcomp|kinase requires|nsubj|outgrowth outgrowth|nummod|END_ENTITY	Voltage-gated Na + channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo .
8817572	0	Fyn	46,49	focal_adhesion_kinase	24,45	Fyn	focal adhesion kinase	25150(Tax:10116)	25614(Tax:10116)	Gene	Gene	association|compound|START_ENTITY association|amod|END_ENTITY	A_beta peptide enhances focal_adhesion_kinase / Fyn association in a rat CNS nerve cell line .
1715582	0	Fyn	66,69	glycoprotein_IV	9,24	Fyn	glycoprotein IV	2534	948	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Membrane glycoprotein_IV -LRB- CD36 -RRB- is physically associated with the Fyn , Lyn , and Yes protein-tyrosine kinases in human platelets .
26306048	0	Fyn	0,3	mTORC1	18,24	Fyn	mTORC1	14360(Tax:10090)	382056(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Fyn Activation of mTORC1 Stimulate the IRE1a-JNK Pathway Leading to Cell Death .
9952416	0	Fyn	58,61	myelin_basic_protein	15,35	Fyn	myelin basic protein	14360(Tax:10090)	17196(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Stimulation of myelin_basic_protein gene transcription by Fyn tyrosine kinase for myelination .
18337055	0	Fyn	57,60	tyrosine_kinase	61,76	Fyn	tyrosine kinase	2534	7294	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of DNA methyltransferase activity upregulates Fyn tyrosine_kinase expression in Hut-78 T-lymphoma cells .
10747096	0	Fyn-binding_protein	0,19	SLP-76-associated_protein	26,51	Fyn-binding protein	SLP-76-associated protein	2533	7871	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Fyn-binding_protein -LRB- Fyb -RRB- / SLP-76-associated_protein -LRB- SLAP -RRB- , Ena/vasodilator-stimulated phosphoprotein -LRB- VASP -RRB- proteins and the Arp2/3 complex link T cell receptor -LRB- TCR -RRB- signaling to the actin cytoskeleton .
25204801	0	G-1	17,20	GPER	111,115	G-1	GPER	5544	2852	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|END_ENTITY	The GPER agonist G-1 induces mitotic_arrest and apoptosis in human vascular smooth muscle cells independent of GPER .
17308128	0	G-1	138,141	G_protein-coupled_receptor_30	0,29	G-1	G protein-coupled receptor 30	5544	2852	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian_cancer cells .
12850494	0	G-6-PD	35,41	Glucose-6-phosphate_dehydrogenase	0,33	G-6-PD	Glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- mutations in Mexico : four new G-6-PD variants .
12956017	0	G-6-PD	35,41	Glucose-6-phosphate_dehydrogenase	0,33	G-6-PD	Glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- levels in jaundiced_neonates in Calabar .
25632835	0	G-6-PD	54,60	glucose-6-phosphate_dehydrogenase	19,52	G-6-PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Relationship among glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity , G-6-PD variants and reticulocytosis in neonates of northeast Thailand .
25632835	0	G-6-PD	72,78	glucose-6-phosphate_dehydrogenase	19,52	G-6-PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Relationship among glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity , G-6-PD variants and reticulocytosis in neonates of northeast Thailand .
3083896	0	G-6-PD	51,57	glucose-6-phosphate_dehydrogenase	16,49	G-6-PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Low erythrocyte glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity and susceptibility to carbaryl-induced methemoglobin formation and glutathione depletion .
4095209	0	G-6-PD	45,51	glucose-6-phosphate_dehydrogenase	10,43	G-6-PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Leucocyte glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity in G-6-PD deficient Chinese .
16280278	0	G-6A	0,4	angiotensinogen	25,40	G-6A	angiotensinogen	23564	183	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	G-6A polymorphism of the angiotensinogen gene and its association with left_ventricular_mass in asymptomatic young adults from a biethnic community : the Bogalusa Heart Study .
12482500	0	G-CSF	45,50	A3_adenosine_receptor	16,37	G-CSF	A3 adenosine receptor	12985(Tax:10090)	11542(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Agonists to the A3_adenosine_receptor induce G-CSF production via NF-kappaB activation : a new class of myeloprotective agents .
23559492	0	G-CSF	0,5	AKT	20,23	G-CSF	AKT	1440	207	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	G-CSF activation of AKT is not sufficient to prolong neutrophil survival .
10688821	0	G-CSF	67,72	Akt	14,17	G-CSF	Akt	1440	207	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY kinase|nmod|granulocyte_colony-stimulating_factor kinase|dep|Activation Activation|nmod|END_ENTITY	Activation of Akt kinase by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- : evidence for the role of a tyrosine kinase activity distinct from the Janus kinases .
12621502	0	G-CSF	54,59	CD133	25,30	G-CSF	CD133	12985(Tax:10090)	19126(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	Large-scale isolation of CD133 + progenitor cells from G-CSF mobilized peripheral blood stem cells .
8555479	0	G-CSF	54,59	CD14	0,4	G-CSF	CD14	1440	929	Gene	Gene	cells|appos|START_ENTITY cells|nummod|END_ENTITY	CD14 + cells in granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow_stroma .
10037043	0	G-CSF	93,98	CD34	56,60	G-CSF	CD34	1440	947	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Modulation Modulation|nmod|expression expression|nmod|END_ENTITY	Modulation of VLA-4 and L-selectin expression on normal CD34 + cells during mobilization with G-CSF .
10414910	0	G-CSF	18,23	CD34	45,49	G-CSF	CD34	1440	947	Gene	Gene	administration|amod|START_ENTITY administration|nmod|+ +|compound|END_ENTITY	Optimal timing of G-CSF administration after CD34 + immunoselected peripheral blood progenitor cell transplantation .
10595815	0	G-CSF	74,79	CD34	133,137	G-CSF	CD34	1440	947	Gene	Gene	using|dobj|START_ENTITY using|parataxis|cost-effective cost-effective|nsubj|collections collections|compound|END_ENTITY	Matched-pair analysis of hematopoietic progenitor cell mobilization using G-CSF vs. cyclophosphamide , etoposide , and G-CSF : enhanced CD34 + cell collections are not necessarily cost-effective .
10738037	0	G-CSF	54,59	CD34	119,123	G-CSF	CD34	1440	947	Gene	Gene	START_ENTITY|nmod|patients patients|acl|failing failing|xcomp|achieve achieve|dobj|numbers numbers|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Successful mobilization of peripheral blood HPCs with G-CSF alone in patients failing to achieve sufficient numbers of CD34 + cells and/or CFU-GM with chemotherapy and G-CSF .
10924094	0	G-CSF	146,151	CD34	25,29	G-CSF	CD34	1440	947	Gene	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|cells cells|amod|END_ENTITY	Mobilization kinetics of CD34 -LRB- + -RRB- cells in association with modulation of CD44 and CD31 expression during continuous intravenous administration of G-CSF in normal donors .
11239221	0	G-CSF	102,107	CD34	0,4	G-CSF	CD34	1440	947	Gene	Gene	course|nmod|START_ENTITY efficacy|nmod|course mobilization|dep|efficacy mobilization|compound|END_ENTITY	CD34 + cell mobilization for allogeneic progenitor cell transplantation : efficacy of a short course of G-CSF .
12424191	0	G-CSF	102,107	CD34	75,79	G-CSF	CD34	1440	947	Gene	Gene	superior|xcomp|START_ENTITY END_ENTITY|ccomp|superior	Retroviral transduction efficiency of G-CSF + SCF-mobilized peripheral blood CD34 + cells is superior to G-CSF or G-CSF + Flt3-L-mobilized cells in nonhuman primates .
12424191	0	G-CSF	38,43	CD34	75,79	G-CSF	CD34	1440	947	Gene	Gene	blood|compound|START_ENTITY efficiency|nmod|blood END_ENTITY|nsubj|efficiency	Retroviral transduction efficiency of G-CSF + SCF-mobilized peripheral blood CD34 + cells is superior to G-CSF or G-CSF + Flt3-L-mobilized cells in nonhuman primates .
15308328	0	G-CSF	0,5	CD34	84,88	G-CSF	CD34	1440	947	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|cells cells|amod|VCAM-1 VCAM-1|nmod|cells cells|acl|promoting promoting|dobj|adhesion adhesion|nmod|+ +|compound|END_ENTITY	G-CSF increases the expression of VCAM-1 on stromal cells promoting the adhesion of CD34 + hematopoietic cells : studies under flow conditions .
16532489	0	G-CSF	147,152	CD34	51,55	G-CSF	CD34	1440	947	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY treated|nmod|granulocyte_colony-stimulating_factor donors|acl|treated cells|nmod|donors factors|dep|cells factors|acl:relcl|affect affect|dobj|mobilization mobilization|nmod|END_ENTITY	Predictive factors that affect the mobilization of CD34 -LRB- + -RRB- cells in healthy donors treated with recombinant granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
16863912	0	G-CSF	0,5	CD34	110,114	G-CSF	CD34	1440	947	Gene	Gene	upregulation|amod|START_ENTITY downregulates|nsubj|upregulation downregulates|dobj|response response|nmod|CD38 CD38|compound|END_ENTITY	G-CSF - and GM-CSF-induced upregulation of CD26 peptidase downregulates the functional chemotactic response of CD34 + CD38 - human cord blood hematopoietic cells .
18457269	0	G-CSF	11,16	CD34	72,76	G-CSF	CD34	1440	947	Gene	Gene	START_ENTITY|dep|cells cells|nummod|+ +|compound|END_ENTITY	-LSB- Effect of G-CSF on the proliferation and differentiation of bcr/abl -LRB- + -RRB- - CD34 + cells from CML patients -RSB- .
19099633	0	G-CSF	15,20	CD34	45,49	G-CSF	CD34	1440	947	Gene	Gene	receptors|amod|START_ENTITY Expression|nmod|receptors Expression|nmod|cells cells|nummod|END_ENTITY	-LSB- Expression of G-CSF and GM-CSF receptors on CD34 positive cells in aplastic_anemia and myelodysplastic_syndrome patients and its significance -RSB- .
19294511	0	G-CSF	0,5	CD34	109,113	G-CSF	CD34	25610(Tax:10116)	305081(Tax:10116)	Gene	Gene	gradient|amod|START_ENTITY associated|nsubj|gradient associated|nmod|mobilization mobilization|nmod|cells cells|compound|END_ENTITY	G-CSF enhanced SDF-1 gradient between bone marrow and liver associated with mobilization of peripheral blood CD34 + cells in rats with acute_liver_failure .
19746588	0	G-CSF	72,77	CD34	10,14	G-CSF	CD34	1440	947	Gene	Gene	delivery|amod|START_ENTITY +|nmod|delivery +|nsubj|END_ENTITY	Bi-phasic CD34 + cell mobilization of a syngeneic donor during prolonged G-CSF delivery .
19899124	0	G-CSF	22,27	CD34	101,105	G-CSF	CD34	1440	947	Gene	Gene	timing|nmod|START_ENTITY use|nsubj|timing use|advcl|increases increases|dobj|yield yield|nmod|cells cells|nummod|END_ENTITY	Appropriate timing of G-CSF use after mobilization chemotherapy significantly increases the yield of CD34 + cells in autoPBSCT .
21392017	0	G-CSF	138,143	CD34	7,11	G-CSF	CD34	1440	947	Gene	Gene	mobilization|dep|START_ENTITY stem|dobj|mobilization stem|nmod|dose dose|compound|END_ENTITY	Beyond CD34 + cell dose : impact of method of peripheral blood hematopoietic stem cell mobilization -LRB- granulocyte-colony-stimulating_factor -LSB- G-CSF -RSB- , G-CSF plus plerixafor , or cyclophosphamide G-CSF/granulocyte-macrophage -LSB- GM -RSB- - CSF -RRB- on number of colony-forming unit-GM , engraftment , and Day +100 hematopoietic graft function .
21729566	0	G-CSF	67,72	CD34	10,14	G-CSF	CD34	1440	947	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|Yield Yield|nmod|cells cells|amod|END_ENTITY	-LSB- Yield of CD34 -LRB- + -RRB- cells in graft can be increased significantly by G-CSF used at appropriate time after chemotherapy for AutoPBSCT -RSB- .
22609881	0	G-CSF	77,82	CD34	54,58	G-CSF	CD34	1440	947	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|count count|nummod|END_ENTITY	Extensive chronic_GVHD is associated with donor blood CD34 + cell count after G-CSF mobilization in non-myeloablative allogeneic PBSC transplantation .
23695795	0	G-CSF	111,116	CD34	21,25	G-CSF	CD34	1440	947	Gene	Gene	administration|amod|START_ENTITY stem|nmod|administration stem|nsubj|model model|nmod|yield yield|nummod|END_ENTITY	Prediction model for CD34 positive cell yield in peripheral blood stem cell collection on the fourth day after G-CSF administration in healthy donors .
23907769	0	G-CSF	44,49	CD34	93,97	G-CSF	CD34	1440	947	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|nmod|mobilization mobilization|nmod|END_ENTITY	Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34 -LRB- + -RRB- hematopoietic progenitor cells in patients > = 60 and < 60 years of age with non-Hodgkin 's _ lymphoma or multiple_myeloma .
23907769	0	G-CSF	67,72	CD34	93,97	G-CSF	CD34	1440	947	Gene	Gene	START_ENTITY|nmod|mobilization mobilization|nmod|END_ENTITY	Safety and efficacy of upfront plerixafor + G-CSF versus placebo + G-CSF for mobilization of CD34 -LRB- + -RRB- hematopoietic progenitor cells in patients > = 60 and < 60 years of age with non-Hodgkin 's _ lymphoma or multiple_myeloma .
24855532	0	G-CSF	81,86	CD34	28,32	G-CSF	CD34	12985(Tax:10090)	12490(Tax:10090)	Gene	Gene	Mobilized|nmod|START_ENTITY Mobilized|nsubj|Study Study|nmod|END_ENTITY	The Primary Study of CD90 -LRB- + -RRB- CD34 -LRB- - -RRB- and Sca-1 -LRB- + -RRB- Stem Cells Mobilized by EPO Plus G-CSF in Mice .
25663039	0	G-CSF	108,113	CD34	78,82	G-CSF	CD34	1440	947	Gene	Gene	Mobilization|compound|START_ENTITY cell|nmod|Mobilization cell|nsubj|use use|nmod|level level|acl|predicting predicting|dobj|efficiency efficiency|nmod|END_ENTITY	The use of hematocrit level for predicting the efficiency of peripheral blood CD34 -LRB- + -RRB- cell collection after G-CSF Mobilization in Healthy Donors .
25834108	0	G-CSF	0,5	CD34	16,20	G-CSF	CD34	1440	947	Gene	Gene	mobilizes|nsubj|START_ENTITY mobilizes|dobj|monocytes monocytes|nummod|+ +|compound|END_ENTITY	G-CSF mobilizes CD34 + regulatory monocytes that inhibit graft-versus-host_disease .
7535443	0	G-CSF	22,27	CD34	81,85	G-CSF	CD34	1440	947	Gene	Gene	prior|nmod:npmod|START_ENTITY collection|advmod|prior collection|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Administration of GM - / G-CSF prior to bone marrow harvest increases collection of CD34 + cells .
7542113	0	G-CSF	159,164	CD34	29,33	G-CSF	CD34	1440	947	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY treated|nmod|granulocyte_colony-stimulating_factor patients|acl|treated +|nmod|patients +|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of enriched CD34 + cells from healthy volunteers and those from patients treated with chemotherapy plus granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
8602984	0	G-CSF	0,5	CD34	50,54	G-CSF	CD34	1440	947	Gene	Gene	mobilizes|nsubj|START_ENTITY mobilizes|dobj|cells cells|compound|END_ENTITY	G-CSF alone mobilizes sufficient peripheral blood CD34 + cells for positive selection in newly diagnosed patients with myeloma .
8950228	0	G-CSF	87,92	CD34	34,38	G-CSF	CD34	1440	947	Gene	Gene	GM-CSF|compound|START_ENTITY mobilized|nmod|GM-CSF products|acl|mobilized subsets|nmod|products subsets|nsubj|+ +|compound|END_ENTITY	Pluripotent and lineage-committed CD34 + subsets in leukapheresis products mobilized by G-CSF , GM-CSF vs. a combination of both .
9089980	0	G-CSF	16,21	CD34	38,42	G-CSF	CD34	1440	947	Gene	Gene	mobilization|amod|START_ENTITY mobilization|nmod|END_ENTITY	The kinetics of G-CSF mobilization of CD34 + cells in healthy people .
9136957	0	G-CSF	137,142	CD34	117,121	G-CSF	CD34	1440	947	Gene	Gene	role|acl|START_ENTITY apoptotic|parataxis|role apoptotic|nmod|cells cells|compound|END_ENTITY	G-CSF-mobilized CD34 peripheral blood stem cells are significantly less apoptotic than unstimulated peripheral blood CD34 cells : role of G-CSF as survival factor .
9136957	0	G-CSF	137,142	CD34	16,20	G-CSF	CD34	1440	947	Gene	Gene	role|acl|START_ENTITY apoptotic|parataxis|role apoptotic|nsubj|cells cells|nummod|END_ENTITY	G-CSF-mobilized CD34 peripheral blood stem cells are significantly less apoptotic than unstimulated peripheral blood CD34 cells : role of G-CSF as survival factor .
9208494	0	G-CSF	91,96	CD34	67,71	G-CSF	CD34	1440	947	Gene	Gene	vitro|nmod|START_ENTITY +|advcl|vitro +|nsubj|Promotion Promotion|nmod|differentiation differentiation|nmod|END_ENTITY	Promotion of differentiation and proliferation of peripheral blood CD34 + cells in vitro by G-CSF .
9257810	0	G-CSF	116,121	CD34	51,55	G-CSF	CD34	1440	947	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY purified|nmod|granulocyte_colony-stimulating_factor cells|acl|purified cells|nummod|END_ENTITY	Transduction of retrovirus-mediated NeoR gene into CD34 + cells purified from granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized infant and cord blood .
9261934	0	G-CSF	74,79	CD34	43,47	G-CSF	CD34	1440	947	Gene	Gene	mobilization|amod|START_ENTITY induced|nmod|mobilization induced|nsubj|Decrease Decrease|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	Decrease in Thy-1 expression on peripheral CD34 positive cells induced by G-CSF mobilization .
9310126	0	G-CSF	64,69	CD34	16,20	G-CSF	CD34	1440	947	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	Mobilization of CD34 + cells by glycosylated and nonglycosylated G-CSF in healthy volunteers -- a comparative study .
9377071	0	G-CSF	160,165	CD34	25,29	G-CSF	CD34	1440	947	Gene	Gene	PIXY321|appos|START_ENTITY +|nmod|PIXY321 +|nsubj|maturation maturation|nmod|END_ENTITY	Neutrophil maturation of CD34 + cells from peripheral blood and bone marrow in serum-free culture medium with PIXY321 and granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- .
9377072	0	G-CSF	91,96	CD34	44,48	G-CSF	CD34	1440	947	Gene	Gene	blood|amod|START_ENTITY progenitors|nmod|blood amplification|nmod|progenitors culture|dep|amplification culture|nmod|cells cells|compound|END_ENTITY	Animal serum-free culture of purified human CD34 + cells : amplification of progenitors from G-CSF and GM-CSF-mobilized peripheral blood .
9433467	0	G-CSF	40,45	CD34	14,18	G-CSF	CD34	1440	947	Gene	Gene	isolated|nmod|START_ENTITY cells|acl|isolated cells|nummod|END_ENTITY	IL-13 induces CD34 + cells isolated from G-CSF mobilized blood to differentiate in vitro into potent antigen presenting cells .
9497891	0	G-CSF	68,73	CD34	84,88	G-CSF	CD34	1440	947	Gene	Gene	transplantation|nmod|START_ENTITY recovery|nmod|transplantation Analysis|nmod|recovery mobilized|nsubj|Analysis mobilized|dobj|cells cells|nummod|END_ENTITY	Analysis of platelet recovery after autologous transplantation with G-CSF mobilized CD34 + cells purified from leukapheresis products .
9535034	0	G-CSF	55,60	CD34	153,157	G-CSF	CD34	1440	947	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY modified|nsubj|granulocyte_colony-stimulating_factor modified|dobj|transplantation transplantation|nmod|content content|compound|END_ENTITY	T cell-depleted granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- modified allogenic bone marrow transplantation for hematological_malignancy improves graft CD34 + cell content but is associated with delayed pancytopenia .
9543059	0	G-CSF	149,154	CD34	0,4	G-CSF	CD34	1440	947	Gene	Gene	mobilized|nmod|START_ENTITY cells|acl|mobilized different|nmod|cells different|nsubj|cells cells|nummod|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9543059	0	G-CSF	149,154	CD34	124,128	G-CSF	CD34	1440	947	Gene	Gene	mobilized|nmod|START_ENTITY cells|acl|mobilized cells|nummod|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9543059	0	G-CSF	85,90	CD34	0,4	G-CSF	CD34	1440	947	Gene	Gene	cells|appos|START_ENTITY cells|nummod|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9543059	0	G-CSF	85,90	CD34	124,128	G-CSF	CD34	1440	947	Gene	Gene	cells|appos|START_ENTITY different|nsubj|cells different|nmod|cells cells|nummod|END_ENTITY	CD34 + cells mobilized by cyclophosphamide and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- are functionally different from CD34 + cells mobilized by G-CSF .
9603397	0	G-CSF	95,100	CD34	29,33	G-CSF	CD34	1440	947	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY mobilized|nmod|granulocyte_colony-stimulating_factor mobilized|nsubj|Analysis Analysis|nmod|cells cells|compound|END_ENTITY	Analysis of peripheral blood CD34 + cells mobilized with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- using a long-term culture system .
11106111	0	G-CSF	59,64	CHOP	25,29	G-CSF	CHOP	1440	1649	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Dose-escalation study of CHOP with or without prophylactic G-CSF in aggressive non-Hodgkin 's _ lymphoma .
16980970	0	G-CSF	0,5	E-selectin	14,24	G-CSF	E-selectin	1440	6401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	G-CSF induces E-selectin ligand expression on human myeloid cells .
25002508	0	G-CSF	0,5	E-selectin	88,98	G-CSF	E-selectin	1440	6401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|glycovariant glycovariant|acl:relcl|operates operates|nmod|ligand ligand|amod|END_ENTITY	G-CSF induces membrane expression of a myeloperoxidase glycovariant that operates as an E-selectin ligand on human myeloid cells .
10613592	0	G-CSF	141,146	EPO	93,96	G-CSF	EPO	1440	2056	Gene	Gene	erythropoietin|appos|START_ENTITY erythropoietin|appos|END_ENTITY	The increase of the rate of hemopoietic recovery and clinical benefit of the erythropoietin -LRB- EPO -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- with peripheral blood progenitor cells -LRB- PBPC -RRB- after intensive cyclic chemotherapy in high-risk breast_cancer patients .
15972155	0	G-CSF	29,34	EPO	49,52	G-CSF	EPO	1440	2056	Gene	Gene	Effect|nmod|START_ENTITY combined|nsubj|Effect combined|nmod|END_ENTITY	-LSB- Effect of recombinant human G-CSF combined with EPO in treatment of patients with MDS -RSB- .
18806833	0	G-CSF	24,29	EPO	0,3	G-CSF	EPO	1440	2056	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	EPO in combination with G-CSF improves mobilization effectiveness after chemotherapy with ifosfamide , epirubicin and etoposide and reduces costs during mobilization and transplantation of autologous hematopoietic progenitor cells .
7687308	0	G-CSF	65,70	EPO	92,95	G-CSF	EPO	1440	2056	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	-LSB- Combination therapy with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and erythropoietin -LRB- EPO -RRB- induced prominent granulocyte increase in an elderly case of myelodysplastic_syndrome -LRB- MDS -RRB- -RSB- .
12375667	0	G-CSF	108,113	G-CSF	167,172	G-CSF	G-CSF	1440	1440	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Equivalent mobilization and collection of granulocytes for transfusion after administration of glycosylated G-CSF -LRB- 3 microg/kg -RRB- plus dexamethasone versus glycosylated G-CSF -LRB- 12 microg/kg -RRB- alone .
12375667	0	G-CSF	167,172	G-CSF	108,113	G-CSF	G-CSF	1440	1440	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Equivalent mobilization and collection of granulocytes for transfusion after administration of glycosylated G-CSF -LRB- 3 microg/kg -RRB- plus dexamethasone versus glycosylated G-CSF -LRB- 12 microg/kg -RRB- alone .
10452050	0	G-CSF	17,22	GM-CSF	41,47	G-CSF	GM-CSF	25610(Tax:10116)	116630(Tax:10116)	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	-LSB- Levels of serum G-CSF and supplement of GM-CSF in rats sustaining delayed resuscitation after major burn -RSB- .
10537336	0	G-CSF	125,130	GM-CSF	86,92	G-CSF	GM-CSF	1440	1437	Gene	Gene	Selective|acl|START_ENTITY Selective|nmod|granulocyte-CSF granulocyte-CSF|appos|END_ENTITY	Selective in vivo mobilization with granulocyte_macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / granulocyte-CSF as compared to G-CSF alone of dendritic cell progenitors from peripheral blood progenitor cells in patients with advanced breast_cancer undergoing autologous transplantation .
10982281	0	G-CSF	18,23	GM-CSF	26,32	G-CSF	GM-CSF	1440	1437	Gene	Gene	Use|nmod|START_ENTITY vs|dep|Use vs|compound|END_ENTITY	Use of concurrent G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells in children with malignant_disease .
10982281	0	G-CSF	36,41	GM-CSF	26,32	G-CSF	GM-CSF	1440	1437	Gene	Gene	START_ENTITY|nsubj|vs vs|compound|END_ENTITY	Use of concurrent G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells in children with malignant_disease .
12621492	0	G-CSF	125,130	GM-CSF	189,195	G-CSF	GM-CSF	1440	1437	Gene	Gene	granulocyte-colony-stimulating_factor|appos|START_ENTITY granulocyte-colony-stimulating_factor|nmod|granulocyte-macrophage_colony-stimulating_factor granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Engraftment syndrome after autologous hematopoietic stem cell transplant supported by granulocyte-colony-stimulating_factor -LRB- G-CSF -RRB- versus granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
1373689	0	G-CSF	222,227	GM-CSF	108,114	G-CSF	GM-CSF	1440	1437	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Retinoic_acid acts to neutralize the inhibitory effect of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on alkaline phosphatase activity of neutrophils that is induced by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
1379838	0	G-CSF	120,125	GM-CSF	31,37	G-CSF	GM-CSF	1440	1437	Gene	Gene	secrete|dobj|START_ENTITY property|acl|secrete produce|nmod|property capable|xcomp|produce precursor|amod|capable precursor|nsubj|cell cell|nmod|END_ENTITY	Hypothesis : the target cell of GM-CSF is a macrophage precursor capable to produce cells with the property to secrete a G-CSF like activity .
16646673	0	G-CSF	213,218	GM-CSF	194,200	G-CSF	GM-CSF	1440	1437	Gene	Gene	followed|nmod|START_ENTITY END_ENTITY|acl|followed	No polarization of type 1 or type 2 precursor dendritic cells in peripheral blood stem cell collections of non-hodgkin 's _ lymphoma patients mobilized with cyclophosphamide plus G-CSF , GM-CSF , or GM-CSF followed by G-CSF .
1696146	0	G-CSF	139,144	GM-CSF	130,136	G-CSF	GM-CSF	1440	1437	Gene	Gene	interleukin-3|advmod|START_ENTITY cyclic_hematopoiesis|amod|interleukin-3 cyclic_hematopoiesis|appos|END_ENTITY	A comparison of treatment of canine cyclic_hematopoiesis with recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , G-CSF interleukin-3 , and canine G-CSF .
1700027	0	G-CSF	6,11	GM-CSF	76,82	G-CSF	GM-CSF	1440	1437	Gene	Gene	produced|nsubj|START_ENTITY produced|nmod|presence presence|nmod|END_ENTITY	Human G-CSF produced by adherent cells in the presence of human recombinant GM-CSF .
1703481	0	G-CSF	89,94	GM-CSF	38,44	G-CSF	GM-CSF	25610(Tax:10116)	116630(Tax:10116)	Gene	Gene	granulocyte-macrophage|appos|START_ENTITY granulocyte-macrophage|appos|END_ENTITY	Production of granulocyte-macrophage -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- by rat clonal osteoblastic cell population CRP 10/30 and the immortalized cell line IRC10/30-myc 1 stimulated by tumor_necrosis_factor_alpha .
1709645	0	G-CSF	182,187	GM-CSF	131,137	G-CSF	GM-CSF	1440	1437	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Modulation by tumor_necrosis_factor-alpha of human astroglial cell production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
18537618	0	G-CSF	67,72	GM-CSF	74,80	G-CSF	GM-CSF	1440	1437	Gene	Gene	factors|appos|START_ENTITY factors|advmod|END_ENTITY	Old friends in new constellations -- the hematopoetic growth factors G-CSF , GM-CSF , and EPO for the treatment of neurological_diseases .
20043577	0	G-CSF	84,89	GM-CSF	147,153	G-CSF	GM-CSF	1440	1437	Gene	Gene	levels|appos|START_ENTITY levels|dep|colony_stimulating_factor colony_stimulating_factor|appos|END_ENTITY	-LSB- The plasma levels and diagnostic utility of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage _ - _ colony_stimulating_factor -LRB- GM-CSF -RRB- in patients with I and II stage of breast_cancer -RSB- .
2483336	0	G-CSF	76,81	GM-CSF	68,74	G-CSF	GM-CSF	12985(Tax:10090)	12981(Tax:10090)	Gene	Gene	Multi-CSF|dep|START_ENTITY Multi-CSF|dep|END_ENTITY	Cellular processing of murine colony-stimulating factor -LRB- Multi-CSF , GM-CSF , G-CSF -RRB- receptors by normal hemopoietic cells and cell lines .
7506580	0	G-CSF	187,192	GM-CSF	194,200	G-CSF	GM-CSF	1440	1437	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
7681699	0	G-CSF	124,129	GM-CSF	73,79	G-CSF	GM-CSF	1440	1437	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Comparative effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy .
7690442	0	G-CSF	195,200	GM-CSF	86,92	G-CSF	GM-CSF	1440	1437	Gene	Gene	provides|advcl|START_ENTITY provides|nsubj|END_ENTITY	Cytogenetic studies of non-lymphocytic_neoplasias using hematopoietic growth factors : GM-CSF provides pronounced mitotic increase and improvement of the quality of banded chromosomes compared to G-CSF .
8552986	0	G-CSF	158,163	GM-CSF	165,171	G-CSF	GM-CSF	1440	1437	Gene	Gene	erythrocytes|dep|START_ENTITY Adhesion|nmod|erythrocytes END_ENTITY|nsubj|Adhesion	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8554685	0	G-CSF	41,46	GM-CSF	48,54	G-CSF	GM-CSF	1440	1437	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
8673471	0	G-CSF	53,58	GM-CSF	114,120	G-CSF	GM-CSF	1440	1437	Gene	Gene	granulocyte_colony_stimulating_factor|appos|START_ENTITY granulocyte_colony_stimulating_factor|appos|END_ENTITY	Expression of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte/macrophage _ colony_stimulating_factor -LRB- GM-CSF -RRB- mRNA upon stimulation with phorbol_ester .
8757506	0	G-CSF	39,44	GM-CSF	209,215	G-CSF	GM-CSF	1440	1437	Gene	Gene	Granulocyte_colony-stimulating_factor|appos|START_ENTITY increases|nsubj|Granulocyte_colony-stimulating_factor increases|parataxis|comparison comparison|nmod|granulocyte-macrophage_colony-stimulating_factor granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- increases neutrophil migration across vascular endothelium independent of an effect on adhesion : comparison with granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
9422470	0	G-CSF	25,30	GM-CSF	33,39	G-CSF	GM-CSF	1440	1437	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|compound|END_ENTITY	Randomized comparison of G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells : effects on hematopoietic recovery after high-dose chemotherapy .
9829843	0	G-CSF	102,107	GM-CSF	86,92	G-CSF	GM-CSF	1440	1437	Gene	Gene	administration|amod|START_ENTITY factor|dobj|administration factor|dep|END_ENTITY	The effect of recombinant human granulocyte/macrophage-colony-stimulating _ factor -LRB- rHu GM-CSF -RRB- and rHu G-CSF administration on neutrophil chemiluminescence assay in patients following cyclic chemotherapy .
1391803	0	G-CSF	23,28	GM-CSF_and_IL-3	30,45	G-CSF	GM-CSF and IL-3	1440	1440;1437;3562	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Comparative effects of G-CSF , GM-CSF_and_IL-3 on cytosine_arabinoside - and daunorubicin-mediated cytotoxicity of acute_myeloid_leukemia cells and normal myeloid progenitors .
17596540	0	G-CSF	38,43	Gfi-1	21,26	G-CSF	Gfi-1	1440	2672	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells .
20203268	0	G-CSF	40,45	Gfi1	25,29	G-CSF	Gfi1	12985(Tax:10090)	14581(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 .
21455770	0	G-CSF	29,34	HSF1	0,4	G-CSF	HSF1	12985(Tax:10090)	15499(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HSF1 regulates expression of G-CSF through the binding element for NF-IL6 / CCAAT enhancer binding protein beta .
10414911	0	G-CSF	93,98	Hematopoietic_growth_factor	0,27	G-CSF	Hematopoietic growth factor	1440	3562	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Hematopoietic_growth_factor after autologous peripheral blood transplantation : comparison of G-CSF and GM-CSF .
10828862	0	G-CSF	0,5	IFN-gamma	14,23	G-CSF	IFN-gamma	25610(Tax:10116)	25712(Tax:10116)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	G-CSF reduces IFN-gamma and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function .
7506580	0	G-CSF	187,192	IL-1	202,206	G-CSF	IL-1	1440	3552	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
15325804	0	G-CSF	40,45	IL-17	20,25	G-CSF	IL-17	1440	3605	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Regulatory roles of IL-17 and IL-17F in G-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha .
22326959	0	G-CSF	35,40	IL-17	29,34	G-CSF	IL-17	100036204(Tax:10090)	16171(Tax:10090)	Gene	Gene	axis|amod|START_ENTITY END_ENTITY|dep|axis	Cxcr2 and Cxcl5 regulate the IL-17 / G-CSF axis and neutrophil homeostasis in mice .
23791509	0	G-CSF	11,16	IL-17	121,126	G-CSF	IL-17	1440	3605	Gene	Gene	therapy|amod|START_ENTITY therapy|dep|remission remission|nmod|restoration restoration|nmod|secretion secretion|compound|END_ENTITY	Continuous G-CSF therapy for isolated chronic_mucocutaneous_candidiasis : complete clinical remission with restoration of IL-17 secretion .
23991206	0	G-CSF	91,96	IL-17	85,90	G-CSF	IL-17	1440	3605	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	LDL cholesterol modulates human CD34 + HSPCs through effects on proliferation and the IL-17 G-CSF axis .
7506580	0	G-CSF	187,192	IL-2	208,212	G-CSF	IL-2	1440	3558	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
8554685	0	G-CSF	41,46	IL-4	23,27	G-CSF	IL-4	1440	3565	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
1893964	0	G-CSF	101,106	IL-6	63,67	G-CSF	IL-6	1440	3569	Gene	Gene	interleukins|dep|START_ENTITY interleukins|dep|IL-1 IL-1|nmod|END_ENTITY	Rapid and sensitive mRNA phenotyping for interleukins -LRB- IL-1 to IL-6 -RRB- and colony-stimulating factors -LRB- G-CSF , M-CSF , and GM-CSF -RRB- by reverse transcription and subsequent polymerase chain reaction .
23630344	0	G-CSF	21,26	IL-6	0,4	G-CSF	IL-6	12985(Tax:10090)	16193(Tax:10090)	Gene	Gene	cooperates|advcl|START_ENTITY cooperates|nsubj|END_ENTITY	IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation .
7542536	0	G-CSF	56,61	IL-6	82,86	G-CSF	IL-6	1440	3569	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	Changes in serum granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and interleukin_6 -LRB- IL-6 -RRB- after surgical intervention .
7683506	0	G-CSF	98,103	IL-6	43,47	G-CSF	IL-6	1440	3569	Gene	Gene	Elevation|appos|START_ENTITY Elevation|nmod|interleukin_6 interleukin_6|appos|END_ENTITY	Elevation of amniotic fluid interleukin_6 -LRB- IL-6 -RRB- , IL-8 and granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in term and preterm parturition .
8554685	0	G-CSF	41,46	IL-6	29,33	G-CSF	IL-6	1440	3569	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
7684703	0	G-CSF	42,47	Interferon-gamma	0,16	G-CSF	Interferon-gamma	1440	3458	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interferon-gamma enhances the LPS-induced G-CSF gene expression in human adherent monocytes , which is regulated at transcriptional and posttranscriptional levels .
18641637	0	G-CSF	25,30	JunB	10,14	G-CSF	JunB	12985(Tax:10090)	16477(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation .
10897214	0	G-CSF	148,153	M-CSF	98,103	G-CSF	M-CSF	1440	1435	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	-LSB- In vitro growth and clinical response of leukemia cells to macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in acute_leukemia -RSB- .
1492809	0	G-CSF	98,103	M-CSF	48,53	G-CSF	M-CSF	1440	1435	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	Origin of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in amniotic fluid .
16685390	0	G-CSF	0,5	M-CSF	13,18	G-CSF	M-CSF	12985(Tax:10090)	12977(Tax:10090)	Gene	Gene	and/or|compound|START_ENTITY END_ENTITY|nsubj|and/or	G-CSF and/or M-CSF accelerate differentiation of bone marrow cells into endothelial progenitor cells in vitro .
17243911	0	G-CSF	55,60	M-CSF	104,109	G-CSF	M-CSF	1440	1435	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	Serum levels of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and macrophage colony-stimulating factor -LRB- M-CSF -RRB- in pancreatic_cancer patients .
18203738	0	G-CSF	35,40	MAD1	18,22	G-CSF	MAD1	1440	8379	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the MAD1 promoter by G-CSF .
11961238	0	G-CSF	77,82	P-selectin_glycoprotein_ligand-1	25,57	G-CSF	P-selectin glycoprotein ligand-1	1440	6404	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Rapid down modulation of P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 , CD162 -RRB- by G-CSF in humans .
12152985	0	G-CSF	86,91	SCF	38,41	G-CSF	SCF	1440	4254	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	The synergy between stem_cell_factor -LRB- SCF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- : molecular basis and clinical relevance .
12815478	0	G-CSF	179,184	SCF	208,211	G-CSF	SCF	100036204(Tax:10090)	17311(Tax:10090)	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	Enhanced antileukemic activity of allogeneic peripheral blood progenitor cell transplants following donor treatment with the combination of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and stem_cell_factor -LRB- SCF -RRB- in a murine transplantation model .
26093947	0	G-CSF	147,152	SDF-1	8,13	G-CSF	SDF-1	100036204(Tax:10090)	20315(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of SDF-1 -LRB- CXCL12 -RRB- in regulating hematopoietic stem and progenitor cells traffic into the liver during extramedullary hematopoiesis induced by G-CSF , AMD3100 and PHZ .
18952897	0	G-CSF	24,29	Serum_amyloid_A	0,15	G-CSF	Serum amyloid A	12985(Tax:10090)	111345(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Serum_amyloid_A induces G-CSF expression and neutrophilia via Toll-like_receptor_2 .
18952897	0	G-CSF	24,29	Toll-like_receptor_2	62,82	G-CSF	Toll-like receptor 2	12985(Tax:10090)	24088(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Serum_amyloid_A induces G-CSF expression and neutrophilia via Toll-like_receptor_2 .
15308328	0	G-CSF	0,5	VCAM-1	34,40	G-CSF	VCAM-1	1440	7412	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	G-CSF increases the expression of VCAM-1 on stromal cells promoting the adhesion of CD34 + hematopoietic cells : studies under flow conditions .
26031531	0	G-CSF	41,46	angiopoietin_1	12,26	G-CSF	angiopoietin 1	100036204(Tax:10090)	11600(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Changes of angiopoietin_1 expression in G-CSF induced hematopoietic stem progenitor cells mobilization -RSB- .
7514046	0	G-CSF	80,85	erythropoietin	22,36	G-CSF	erythropoietin	1440	2056	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A randomized study of erythropoietin and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- versus placebo and G-CSF for patients with Hodgkin 's _ and_non-Hodgkin 's _ lymphoma undergoing autologous bone marrow transplantation .
15894583	0	G-CSF	58,63	gp49B	39,44	G-CSF	gp49B	12985(Tax:10090)	14728(Tax:10090)	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Identification of CCR2 , flotillin , and gp49B genes as new G-CSF targets during neutrophilic differentiation .
16258290	0	G-CSF	11,16	granulocyte-colony_stimulating_factor	18,55	G-CSF	granulocyte-colony stimulating factor	1440	1440	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for G-CSF -LRB- granulocyte-colony_stimulating_factor -RRB- in the central nervous system .
19494436	0	G-CSF	66,71	granulocyte-colony_stimulating_factor	27,64	G-CSF	granulocyte-colony stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Decreased plasma levels of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- in patients with early Alzheimer 's _ disease .
20043577	0	G-CSF	84,89	granulocyte-colony_stimulating_factor	45,82	G-CSF	granulocyte-colony stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	-LSB- The plasma levels and diagnostic utility of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage _ - _ colony_stimulating_factor -LRB- GM-CSF -RRB- in patients with I and II stage of breast_cancer -RSB- .
20557950	0	G-CSF	117,122	granulocyte-colony_stimulating_factor	78,115	G-CSF	granulocyte-colony stimulating factor	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Neuroprotective effect of Fn14_deficiency is associated with induction of the granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody .
21999467	0	G-CSF	50,55	granulocyte-colony_stimulating_factor	11,48	G-CSF	granulocyte-colony stimulating factor	25610(Tax:10116)	25610(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- on diabetic_cardiomyopathy in Otsuka Long-Evans Tokushima fatty rats .
7524265	0	G-CSF	49,54	granulocyte-colony_stimulating_factor	10,47	G-CSF	granulocyte-colony stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increased granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- levels in neonates with perinatal complications .
7525437	0	G-CSF	46,51	granulocyte-colony_stimulating_factor	7,44	G-CSF	granulocyte-colony stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Serum granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- levels in elderly patients with infections -RSB- .
7528531	0	G-CSF	55,60	granulocyte-colony_stimulating_factor	16,53	G-CSF	granulocyte-colony stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- in bacterial and viral_infections , and in atypical_pneumonia .
7516556	0	G-CSF	98,103	granulocyte-macrophage_colony_stimulating_factor	48,96	G-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Treatment of drug induced agranulocytosis with granulocyte-macrophage_colony_stimulating_factor -LRB- G-CSF -RRB- -RSB- .
10364174	0	G-CSF	54,59	granulocyte_colony-stimulating_factor	15,52	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- with its receptor .
11523133	0	G-CSF	83,88	granulocyte_colony-stimulating_factor	44,81	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- A case of Bellini_duct_carcinoma producing granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- -RSB- .
12040470	0	G-CSF	51,56	granulocyte_colony-stimulating_factor	12,49	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in the post-transplant period .
12456601	0	G-CSF	57,62	granulocyte_colony-stimulating_factor	18,55	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Cyclic changes of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- mRNA in the human follicle during the normal menstrual cycle and immunolocalization of G-CSF protein .
12636092	0	G-CSF	50,55	granulocyte_colony-stimulating_factor	11,48	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Endogenous granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- levels in chemotherapy-induced neutropenia and in neutropenia related with primary_diseases .
1371630	0	G-CSF	84,89	granulocyte_colony-stimulating_factor	45,82	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Chronic congenital_neutropenia treated with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- -RSB- .
1373092	0	G-CSF	51,56	granulocyte_colony-stimulating_factor	12,49	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- levels after allogeneic and autologous bone marrow transplantation : endogenous G-CSF production correlates with myeloid engraftment .
1374055	0	G-CSF	70,75	granulocyte_colony-stimulating_factor	28,65	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rh G-CSF -RRB- on murine resistance against Listeria_monocytogenes .
14510752	0	G-CSF	49,54	granulocyte_colony-stimulating_factor	10,47	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - supported chemotherapy on MR imaging of normal red bone marrow in breast_cancer patients with focal bone metastases .
15644577	0	G-CSF	63,68	granulocyte_colony-stimulating_factor	24,61	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in antithyroid drug-induced agranulocytosis .
16410701	0	G-CSF	148,153	granulocyte_colony-stimulating_factor	109,146	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Two cases of malignant_lymphoma with high fever and C-reactive_protein -LRB- CRP -RRB- elevation after treatment with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- -RSB- .
18602391	0	G-CSF	84,89	granulocyte_colony-stimulating_factor	45,82	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of recombinant human granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in neurodegeneration after optic nerve crush in rats .
2020039	0	G-CSF	53,58	granulocyte_colony-stimulating_factor	14,51	G-CSF	granulocyte colony-stimulating factor	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- upon burn-induced defective neutrophil chemotaxis .
21123967	0	G-CSF	78,83	granulocyte_colony-stimulating_factor	39,76	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Cell cycle-dependent priming action of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- enhances in vitro apoptosis induction by cytarabine and etoposide in leukemia cell lines .
21396452	0	G-CSF	79,84	granulocyte_colony-stimulating_factor	40,77	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Soluble periplasmic production of human granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in Pseudomonas_fluorescens .
24316388	0	G-CSF	84,89	granulocyte_colony-stimulating_factor	45,82	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of recombinant human granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in a rat model of anterior_ischemic_optic_neuropathy -LRB- rAION -RRB- .
3257647	0	G-CSF	72,77	granulocyte_colony-stimulating_factor	33,70	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of purified human native granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on proliferation of blast progenitors in acute_myeloblastic_leukemia .
6602806	0	G-CSF	73,78	granulocyte_colony-stimulating_factor	34,71	G-CSF	granulocyte colony-stimulating factor	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Proliferative effects of purified granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on normal mouse hemopoietic cells .
7507094	0	G-CSF	61,66	granulocyte_colony-stimulating_factor	22,59	G-CSF	granulocyte colony-stimulating factor	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Therapeutic effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on the protection against Listeria_infection in SCID mice .
7530467	0	G-CSF	114,119	granulocyte_colony-stimulating_factor	75,112	G-CSF	granulocyte colony-stimulating factor	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- expression in bone marrow and fractionated marrow cell populations by interleukin_3 -LRB- IL-3 -RRB- : IL-3-mediated positive feedback mechanisms of granulopoiesis .
7543781	0	G-CSF	49,54	granulocyte_colony-stimulating_factor	10,47	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on chemotherapy-induced oral_mucositis .
7545505	0	G-CSF	63,68	granulocyte_colony-stimulating_factor	24,61	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- determined by a highly-sensitive chemiluminescent immunoassay during the clinical course of subacute_thyroiditis .
7581097	0	G-CSF	45,50	granulocyte_colony-stimulating_factor	6,43	G-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- levels after allogeneic T_cell-depleted marrow transplantation .
9164511	0	G-CSF	53,58	granulocyte_colony-stimulating_factor	14,51	G-CSF	granulocyte colony-stimulating factor	25610(Tax:10116)	25610(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on bacterial translocation in the splenectomized rat .
18335482	0	G-CSF	54,59	granulocyte_colony_stimulating_factor	15,52	G-CSF	granulocyte colony stimulating factor	1440	1440	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Pilot study of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood stem cells in amyotrophic_lateral_sclerosis -LRB- ALS -RRB- .
19322972	0	G-CSF	47,52	granulocyte_colony_stimulating_factor	8,45	G-CSF	granulocyte colony stimulating factor	1440	1440	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in chemotherapy induced neutropenia .
7531660	0	G-CSF	50,55	granulocyte_colony_stimulating_factor	11,48	G-CSF	granulocyte colony stimulating factor	1440	1440	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- on peripheral blood leukocytes and lymphocytes in patients with chemotherapy-induced leukopenia -RSB- .
9066582	0	G-CSF	58,63	granulocyte_colony_stimulating_factor	19,56	G-CSF	granulocyte colony stimulating factor	1440	1440	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in non-small cell lung_cancer .
8955505	0	G-CSF	123,128	interleukin-1_beta	143,161	G-CSF	interleukin-1 beta	1440	3553	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Human endometrial expression of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and its receptor , stimulation of endometrial G-CSF production by interleukin-1_beta , and G-CSF inhibition of choriocarcinoma cell proliferation .
2453230	0	G-CSF	77,82	interleukin-3	19,32	G-CSF	interleukin-3	1440	3562	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro .
18432817	0	G-CSF	80,85	interleukin_3	15,28	G-CSF	interleukin 3	1440	3562	Gene	Gene	GM-CSF|appos|START_ENTITY Measurement|nmod|GM-CSF Measurement|nmod|END_ENTITY	Measurement of interleukin_3 and other hematopoietic cytokines , such as GM-CSF , G-CSF , M-CSF , erythropoietin , steel_factor , and Flt-3_ligand .
7530467	0	G-CSF	114,119	interleukin_3	191,204	G-CSF	interleukin 3	12985(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Induction of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- expression in bone marrow and fractionated marrow cell populations by interleukin_3 -LRB- IL-3 -RRB- : IL-3-mediated positive feedback mechanisms of granulopoiesis .
7507758	0	G-CSF	96,101	stem_cell_factor	12,28	G-CSF	stem cell factor	100036204(Tax:10090)	17311(Tax:10090)	Gene	Gene	synergy|nmod|START_ENTITY role|dep|synergy role|nmod|END_ENTITY	The role of stem_cell_factor in mobilization of peripheral blood progenitor cells : synergy with G-CSF .
7681048	0	G-CSF	70,75	stem_cell_factor	23,39	G-CSF	stem cell factor	25610(Tax:10116)	60427(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Hematologic effects of stem_cell_factor alone and in combination with G-CSF and GM-CSF in vivo and in vitro in rodents .
9712486	0	G-CSF	101,106	stem_cell_factor	111,127	G-CSF	stem cell factor	100036204(Tax:10090)	17311(Tax:10090)	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|advmod|as as|nmod:npmod|END_ENTITY	Superior antileukemic activity of murine peripheral blood progenitor cell -LRB- PBPC -RRB- grafts mobilized by G-CSF and stem_cell_factor -LRB- SCF -RRB- as compared to G-CSF alone .
17127322	0	G-CSF-R	64,71	granulocyte_colony-stimulating_factor_receptor	16,62	G-CSF-R	granulocyte colony-stimulating factor receptor	1441	1441	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the granulocyte_colony-stimulating_factor_receptor -LRB- G-CSF-R -RRB- in disease .
7531515	0	G-CSF-R	72,79	granulocyte_colony-stimulating_factor_receptor	24,70	G-CSF-R	granulocyte colony-stimulating factor receptor	1441	1441	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A point mutation in the granulocyte_colony-stimulating_factor_receptor -LRB- G-CSF-R -RRB- gene in a case of acute_myeloid_leukemia results in the overexpression of a novel G-CSF-R isoform .
18637807	0	G-CSFR	24,30	CD34	58,62	G-CSFR	CD34	1441	947	Gene	Gene	expressions|compound|START_ENTITY expressions|nmod|END_ENTITY	Comparative analysis of G-CSFR and GM-CSFR expressions on CD34 + cells in patients with aplastic_anemia and myelodysplastic_syndrome .
23820376	0	G-CSFR	88,94	Fbw7	20,24	G-CSFR	Fbw7	1441	55294	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation .
10643150	0	G-CSFR	110,116	Lyn	26,29	G-CSFR	Lyn	1441	4067	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte_colony-stimulating_factor receptor -LRB- G-CSFR -RRB- is not abrogated in neutrophils from severe congenital_neutropenia patients with point mutations in the G-CSFR mRNA .
10848795	0	G-CSF_receptor	24,38	CD34	77,81	G-CSF receptor	CD34	1441	947	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Exclusive expression of G-CSF_receptor on myeloid progenitors in bone marrow CD34 + cells .
7533100	0	G-CSF_receptor	51,65	CD34	77,81	G-CSF receptor	CD34	1441	947	Gene	Gene	progenitors|amod|START_ENTITY progenitors|compound|END_ENTITY	High-frequency granuloid colony-forming ability of G-CSF_receptor possessing CD34 antigen positive human umbilical cord blood hematopoietic progenitors .
21636860	0	G-CSF_receptor	0,14	Lyn	44,47	G-CSF receptor	Lyn	12986(Tax:10090)	17096(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	G-CSF_receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase .
26585160	0	G-Protein_Coupled_Receptor_30	12,41	GPR30	43,48	G-Protein Coupled Receptor 30	GPR30	2852	2852	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of G-Protein_Coupled_Receptor_30 -LRB- GPR30 -RRB- on Endothelial Inflammation .
22834040	0	G-Protein_Coupled_Receptor_7	55,83	GPR7	85,89	G-Protein Coupled Receptor 7	GPR7	2831	2831	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Optimization and Characterization of an Antagonist for G-Protein_Coupled_Receptor_7 -LRB- GPR7 -RRB- Heterotrimeric G-protein coupled receptors -LRB- GPCRs -RRB- , the largest family of membrane-bound receptors , are major targets for therapeutic applications due to their broad tissue distribution , structural diversity , varied modes of action , and disease-associated mutations .
23338946	0	G-Protein_coupled_receptor_64	0,29	PGF	93,96	G-Protein coupled receptor 64	PGF	237175(Tax:10090)	18654(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	G-Protein_coupled_receptor_64 promotes invasiveness and metastasis in Ewing_sarcomas through PGF and MMP1 .
8886169	0	G-olf_alpha	35,46	GNAL	48,52	G-olf alpha	GNAL	2774	2774	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Linkage disequilibrium analysis of G-olf_alpha -LRB- GNAL -RRB- in bipolar_affective_disorder .
19758793	0	G-protein-coupled_receptor_40	0,29	GPR40	31,36	G-protein-coupled receptor 40	GPR40	2864	2864	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	G-protein-coupled_receptor_40 -LRB- GPR40 -RRB- expression and its regulation in human pancreatic islets : the role of type 2 diabetes and fatty_acids .
19633298	0	G-protein-coupled_receptor_81	92,121	Peroxisome_proliferator-activated_receptor_gamma	0,48	G-protein-coupled receptor 81	Peroxisome proliferator-activated receptor gamma	27198	5468	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma regulates expression of the anti-lipolytic G-protein-coupled_receptor_81 -LRB- GPR81/Gpr81 -RRB- .
25881750	0	G-protein-coupled_receptor_81	22,51	hydroxycarboxylic_acid_receptor_1	52,85	G-protein-coupled receptor 81	hydroxycarboxylic acid receptor 1	27198	27198	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	The lactate receptor , G-protein-coupled_receptor_81 / hydroxycarboxylic_acid_receptor_1 : Expression and action in brain .
24764294	0	G-protein-coupled_receptor_kinase-interacting_protein_1	62,117	GIT1	119,123	G-protein-coupled receptor kinase-interacting protein 1	GIT1	28964	28964	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- is activated through G-protein-coupled_receptor_kinase-interacting_protein_1 -LRB- GIT1 -RRB- tyrosine phosphorylation and Src protein .
22096079	0	G-protein-coupled_receptor_kinase_2	11,46	Hedgehog	72,80	G-protein-coupled receptor kinase 2	Hedgehog	49045(Tax:7227)	42737(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Drosophila G-protein-coupled_receptor_kinase_2 regulates cAMP-dependent Hedgehog signaling .
19008357	0	G-protein-coupled_receptor_kinase_5	4,39	NFkappaB	49,57	G-protein-coupled receptor kinase 5	NFkappaB	2869	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	The G-protein-coupled_receptor_kinase_5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB_alpha .
20124405	0	G-protein-coupled_receptor_kinase_5	0,35	p53	51,54	G-protein-coupled receptor kinase 5	p53	14773(Tax:10090)	22060(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	G-protein-coupled_receptor_kinase_5 phosphorylates p53 and inhibits DNA damage-induced apoptosis .
23359120	0	G-protein-coupled_receptor_kinase_6	14,49	GRK6	51,55	G-protein-coupled receptor kinase 6	GRK6	59076(Tax:10116)	59076(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of G-protein-coupled_receptor_kinase_6 -LRB- GRK6 -RRB- after acute spinal_cord_injury in adult rat .
23762933	0	G-protein_Coupled_Receptor_7	61,89	GPR7	91,95	G-protein Coupled Receptor 7	GPR7	2831	2831	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Optimization and Characterization of a Second Antagonist for G-protein_Coupled_Receptor_7 -LRB- GPR7 -RRB- Heterotrimeric G-protein coupled receptors -LRB- GPCRs -RRB- , the largest family of membrane-bound receptors , are major targets for therapeutic applications due to their broad tissue distribution , structural diversity , varied modes of action , and disease-associated mutations .
18070145	0	G-protein_alpha_subunit	171,194	gsp	196,199	G-protein alpha subunit	gsp	2778	2778	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Expression of pituitary_tumour-derived , N-terminally truncated isoform of fibroblast_growth_factor_receptor_4 -LRB- ptd-FGFR4 -RRB- correlates with tumour invasiveness but not with G-protein_alpha_subunit -LRB- gsp -RRB- mutation in human GH-secreting pituitary_adenomas .
15019160	0	G-protein_beta-3_subunit	31,55	GNB3	62,66	G-protein beta-3 subunit	GNB3	2784	2784	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The 825C > T polymorphism of the G-protein_beta-3_subunit gene -LRB- GNB3 -RRB- and breast_cancer .
16498633	0	G-protein_beta2_subunit	54,77	Ataxin_10	0,9	G-protein beta2 subunit	Ataxin 10	2783	25814	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Ataxin_10 induces neuritogenesis via interaction with G-protein_beta2_subunit .
11008983	0	G-protein_beta3	0,15	GNB3	30,34	G-protein beta3	GNB3	2784	2784	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	G-protein_beta3 subunit gene -LRB- GNB3 -RRB- polymorphism 825C -- > T in patients with hypertensive crisis .
16513451	0	G-protein_beta3	161,176	GNB3	186,190	G-protein beta3	GNB3	2784	2784	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The angiotensin_II receptor antagonist valsartan inhibits endothelin_1-induced vasoconstriction in the skin microcirculation in humans in vivo : influence of the G-protein_beta3 subunit -LRB- GNB3 -RRB- C825T polymorphism .
9856980	0	G-protein_beta3	0,15	GNB3	30,34	G-protein beta3	GNB3	2784	2784	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	G-protein_beta3 subunit gene -LRB- GNB3 -RRB- variant in causation of essential hypertension .
23144692	0	G-protein_coupled_receptor	21,47	GPCR	49,53	G-protein coupled receptor	GPCR	10663	10663	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Multiple analyses of G-protein_coupled_receptor -LRB- GPCR -RRB- expression in the development of gefitinib-resistance in transforming non-small-cell_lung_cancer .
25078448	0	G-protein_coupled_receptor	43,69	GPCR	71,75	G-protein coupled receptor	GPCR	23890(Tax:10090)	23890(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Application of in utero electroporation of G-protein_coupled_receptor -LRB- GPCR -RRB- genes , for subcellular localization of hardly identifiable GPCR in mouse cerebral cortex .
24730523	0	G-protein_coupled_receptor_124	0,30	vascular_endothelial_growth_factor	71,105	G-protein coupled receptor 124	vascular endothelial growth factor	25960	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	G-protein_coupled_receptor_124 -LRB- GPR124 -RRB- in endothelial cells regulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced tumor angiogenesis .
25363403	0	G-protein_coupled_receptor_34	0,29	Erk	40,43	G-protein coupled receptor 34	Erk	23890(Tax:10090)	26413(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|pathways pathways|compound|END_ENTITY	G-protein_coupled_receptor_34 activates Erk and phosphatidylinositol 3-kinase/Akt pathways and functions as alternative pathway to mediate p185Bcr-Abl-induced transformation_and_leukemogenesis .
21110987	0	G-protein_coupled_receptor_35	0,29	GPR35	31,36	G-protein coupled receptor 35	GPR35	64095(Tax:10090)	64095(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	G-protein_coupled_receptor_35 -LRB- GPR35 -RRB- activation and inflammatory_pain : Studies on the antinociceptive effects of kynurenic_acid and zaprinast .
23335960	0	G-protein_coupled_receptor_83	0,29	GPR83	31,36	G-protein coupled receptor 83	GPR83	14608(Tax:10090)	14608(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	G-protein_coupled_receptor_83 -LRB- GPR83 -RRB- signaling determined by constitutive and zinc -LRB- II -RRB- - induced activity .
7606925	0	G-protein_gamma_5_subunit	35,60	GNG5	62,66	G-protein gamma 5 subunit	GNG5	2787	2787	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Lysosomal chitobiase -LRB- CTB -RRB- and the G-protein_gamma_5_subunit -LRB- GNG5 -RRB- genes co-localize to human chromosome 1p22 .
16374707	0	G-protein_receptor_kinase_3	36,63	beta-arrestin-2	65,80	G-protein receptor kinase 3	beta-arrestin-2	157	409	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	The fine-structural distribution of G-protein_receptor_kinase_3 , beta-arrestin-2 , Ca2 + / calmodulin-dependent_protein_kinase_II and phosphodiesterase PDE1C2 , and a Cl -LRB- - -RRB- - cotransporter in rodent olfactory epithelia .
26267306	0	G-quadruplexes	24,38	Aven	0,4	G-quadruplexes	Aven	57827	57099	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	Aven recognition of RNA G-quadruplexes regulates translation of the mixed_lineage_leukemia protooncogenes .
26267306	0	G-quadruplexes	24,38	Aven	0,4	G-quadruplexes	Aven	57827	57099	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	Aven recognition of RNA G-quadruplexes regulates translation of the mixed_lineage_leukemia protooncogenes .
7692628	0	G.CSF	11,16	IL-1_beta	18,27	G.CSF	IL-1 beta	1440	3553	Gene	Gene	HILDA/LIF|amod|START_ENTITY HILDA/LIF|amod|END_ENTITY	HILDA/LIF , G.CSF , IL-1_beta , IL-6 , and TNF_alpha production during acute rejection of human kidney allografts .
7692628	0	G.CSF	11,16	IL-6	29,33	G.CSF	IL-6	1440	3569	Gene	Gene	HILDA/LIF|amod|START_ENTITY HILDA/LIF|amod|END_ENTITY	HILDA/LIF , G.CSF , IL-1_beta , IL-6 , and TNF_alpha production during acute rejection of human kidney allografts .
8985116	0	G0S3	81,85	FOSB	70,74	G0S3	FOSB	2354	2354	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence analysis and expression in cultured lymphocytes of the human FOSB gene -LRB- G0S3 -RRB- .
17611392	6	G12V	1189,1193	KRAS	1184,1188	IGF1	KRAS	3479	3845	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	A series of such KRAS radiohybridization probes with 0 , 1 , 2 or 3 mismatches to KRAS G12D mRNA , including exact matches to wild type KRAS mRNA and KRAS G12V mRNA , along with a double d -LRB- Ala -RRB- replacement IGF1 peptide control , were assembled by continuous solid phase synthesis .
8870652	0	G13	9,12	MHC	50,53	G13	MHC	1388	3133	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein .
20180778	0	G3BP	45,49	MK-STYX	22,29	G3BP	MK-STYX	10146	51657	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation .
24321297	0	G3BP1	28,33	PMP22	14,19	G3BP1	PMP22	10146	5376	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast_cancer cells .
22205990	0	G3BP1	11,16	RasGAP	22,28	G3BP1	RasGAP	10146	5921	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Revisiting G3BP1 as a RasGAP binding protein : sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1 .
22536444	0	G3BP2	11,16	PKCa	0,4	G3BP2	PKCa	9908	5578	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	PKCa binds G3BP2 and regulates stress granule formation following cellular stress .
18449899	0	G6PC	46,50	glucose-6-phosphatase-alpha	17,44	G6PC	glucose-6-phosphatase-alpha	2538	2538	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the glucose-6-phosphatase-alpha -LRB- G6PC -RRB- gene that cause type Ia glycogen storage disease .
10738525	0	G6PC	79,83	glucose-6_phosphatase	56,77	G6PC	glucose-6 phosphatase	2538	2538	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Enzymatic characterization of four new mutations in the glucose-6_phosphatase -LRB- G6PC -RRB- gene which cause glycogen_storage_disease_type_1a .
19434206	0	G6PD	35,39	Glucose-6-phosphate_dehydrogenase	0,33	G6PD	Glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- activity and deficiency in a population of Nigerian males resident in Jos. The activity of red blood cell Glucose_6-phosphate dehydrogenase -LRB- G6PD -RRB- in one hundred and twenty six healthy male individuals who are Nigerians residing in Jos was evaluated .
2208076	0	G6PD	35,39	Glucose-6-phosphate_dehydrogenase	0,33	G6PD	Glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- activity in tumoral tissues of G6PD-deficient subjects affected by larynx_carcinoma .
26291555	0	G6PD	49,53	SM22a	15,20	G6PD	SM22a	2539	6876	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	TRAF6-Mediated SM22a K21 Ubiquitination Promotes G6PD Activation and NADPH Production , Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo .
26291555	0	G6PD	49,53	SM22a	15,20	G6PD	SM22a	2539	6876	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	TRAF6-Mediated SM22a K21 Ubiquitination Promotes G6PD Activation and NADPH Production , Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo .
10709108	0	G6PD	41,45	glucose-6-phosphate_dehydrogenase	6,39	G6PD	glucose-6-phosphate dehydrogenase	14380(Tax:10090)	14380(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Human glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- gene transforms NIH 3T3 cells and induces tumors in nude_mice .
10869567	0	G6PD	44,48	glucose-6-phosphate_dehydrogenase	9,42	G6PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	status|compound|START_ENTITY status|amod|END_ENTITY	Cellular glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- status modulates the effects of nitric_oxide -LRB- NO -RRB- on human foreskin fibroblasts .
1562739	0	G6PD	69,73	glucose-6-phosphate_dehydrogenase	34,67	G6PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Diverse point mutations result in glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- polymorphism in Taiwan .
4405142	0	G6PD	73,77	glucose-6-phosphate_dehydrogenase	29,62	G6PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effect of 17-ketosteroids on glucose-6-phosphate_dehydrogenase activity -LRB- G6PD -RRB- and on G6PD isoenzymes .
6431656	0	G6PD	61,65	glucose-6-phosphate_dehydrogenase	26,59	G6PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Depression of erythrocyte glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- activity in enteric_fever .
7607684	0	G6PD	92,96	glucose-6-phosphate_dehydrogenase	52,85	G6PD	glucose-6-phosphate dehydrogenase	101071498	101071498	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and sequence of the Fugu_rubripes glucose-6-phosphate_dehydrogenase gene -LRB- G6PD -RRB- .
8333738	0	G6PD	44,48	glucose-6-phosphate_dehydrogenase	9,42	G6PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	Study|appos|START_ENTITY Study|nmod|END_ENTITY	Study of glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- in the Kissan tribals of Orissa and the Kannikar tribals of Kerala , India .
9332310	0	G6PD	60,64	glucose-6-phosphate_dehydrogenase	25,58	G6PD	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two new mutations of the glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- gene associated with haemolytic_anaemia : clinical , biochemical and molecular relationships .
3090637	0	G6PDH	35,40	Glucose-6-phosphate-dehydrogenase	0,33	G6PDH	Glucose-6-phosphate-dehydrogenase	101824850	101824850	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Glucose-6-phosphate-dehydrogenase -LRB- G6PDH -RRB- activity in the liver of golden_hamsters -- its dependence from estrous cycle and consequences on planning experiments .
10996244	0	G6PDH	58,63	glucose-6-phosphate_dehydrogenase	23,56	G6PDH	glucose-6-phosphate dehydrogenase	542778(Tax:4565)	542778(Tax:4565)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Specific expression of glucose-6-phosphate_dehydrogenase -LRB- G6PDH -RRB- gene by salt stress in wheat -LRB- Triticum_aestivum_L . -RRB- .
21870182	0	G6PDH	96,101	glucose-6-phosphate_dehydrogenase	61,94	G6PDH	glucose-6-phosphate dehydrogenase	2539	2539	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Prediction of oocyte developmental competence in ovine using glucose-6-phosphate_dehydrogenase -LRB- G6PDH -RRB- activity determined at retrieval time .
12546415	0	G6Pase	37,43	glucose-6-phosphatase	14,35	G6Pase	glucose-6-phosphatase	25634(Tax:10116)	25634(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Thielavins as glucose-6-phosphatase -LRB- G6Pase -RRB- inhibitors : producing strain , fermentation , isolation , structural elucidation and biological activities .
11544253	0	G6b	0,3	SHP-1	117,122	G6b	SHP-1	80739	5777	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	G6b , a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex , interacts with SHP-1 and SHP-2 .
12852788	0	G6f	65,68	Grb2	28,32	G6f	Grb2	259215	2885	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f , a novel member of the immunoglobulin superfamily encoded in the MHC .
24990928	0	G9a	20,23	MeCP2	0,5	G9a	MeCP2	110147(Tax:10090)	17257(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	MeCP2 repression of G9a in regulation of pain and morphine reward .
14985713	0	G9a	51,54	PRDI-BF1	0,8	G9a	PRDI-BF1	10919	639	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing .
22389001	0	G9a	27,30	Runx2	34,39	G9a	Runx2	10919	860	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription .
22406531	0	G9a	0,3	Snail	19,24	G9a	Snail	10919	6615	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast_cancer .
19056828	0	G9a	12,15	UHRF1	0,5	G9a	UHRF1	10919	29128	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells .
25765655	0	G9a	23,26	UHRF1	48,53	G9a	UHRF1	10919	29128	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation .
23402890	0	GAA	83,86	CCDC40	104,110	GAA	CCDC40	2548	55036	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Identification of the first deletion-insertion involving the complete structure of GAA gene and part of CCDC40 gene mediated by an Alu element .
17498922	0	GAA	36,39	Friedreich_ataxia	67,84	GAA	Friedreich ataxia	2548	2395	Gene	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Somatic instability of the expanded GAA triplet-repeat sequence in Friedreich_ataxia progresses throughout life .
10194437	0	GAB1	55,59	Erythropoietin	0,14	GAB1	Erythropoietin	2549	2056	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC , SHP2 , SHIP , and phosphatidylinositol 3-kinase .
26359300	0	GAB1	89,93	SHP2	73,77	GAB1	SHP2	2549	5781	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	EGF augments TGFb-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1 .
8972548	0	GABA-A	8,14	diazepam_binding_inhibitor	33,59	GABA-A	diazepam binding inhibitor	14405(Tax:10090)	13167(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Role of GABA-A and mitochondrial diazepam_binding_inhibitor receptors in the anti-stress activity of neurosteroids in mice .
9105679	0	GABAA_receptor_alpha_6	4,26	Gabra6	41,47	GABAA receptor alpha 6	Gabra6	14399(Tax:10090)	14399(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The GABAA_receptor_alpha_6 subunit gene -LRB- Gabra6 -RRB- is tightly linked to the alpha 1-gamma 2 subunit cluster on mouse chromosome 11 .
8411721	0	GABAA_receptor_beta_3-subunit	5,34	GABRB3	41,47	GABAA receptor beta 3-subunit	GABRB3	2562	2562	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- The GABAA_receptor_beta_3-subunit gene -LRB- GABRB3 -RRB- as a candidate responsible for central nerve disturbances in Angelman_syndrome -LRB- AS -RRB- -RSB- .
24240096	0	GABARAP	83,90	Bcl-2	15,20	GABARAP	Bcl-2	11337	596	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Interaction of Bcl-2 with the autophagy-related GABAA receptor-associated protein -LRB- GABARAP -RRB- : biophysical characterization and functional implications .
25126726	0	GABARAP	50,57	FLCN	0,4	GABARAP	FLCN	11337	201163	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FLCN , a novel autophagy component , interacts with GABARAP and is regulated by ULK1 phosphorylation .
19363302	0	GABARAP	22,29	Nix	0,3	GABARAP	Nix	11337	665	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Nix directly binds to GABARAP : a possible crosstalk between apoptosis and autophagy .
26986052	0	GABARAP	0,7	ULK1	18,22	GABARAP	ULK1	11337	8408	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130 .
11997026	0	GABARAP	47,54	transferrin_receptor	21,41	GABARAP	transferrin receptor	11337	7037	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human transferrin_receptor with GABARAP .
24204963	0	GABARAPL2	66,75	GIMAP6	25,31	GABARAPL2	GIMAP6	11345	474344	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The immune system GTPase GIMAP6 interacts with the Atg8 homologue GABARAPL2 and is recruited to autophagosomes .
11840313	0	GABA_receptor	37,50	GABRA3	57,63	GABA receptor	GABRA3	11337	2556	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Excess of allele1 for alpha3 subunit GABA_receptor gene -LRB- GABRA3 -RRB- in bipolar patients : a multicentric association study .
14751442	0	GABA_receptor	74,87	GABRA3	94,100	GABA receptor	GABRA3	11337	2556	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association between polymorphic variations in the alpha 3 subunit GABA_receptor gene -LRB- GABRA3 -RRB- and suicide attempts .
26450699	0	GABA_receptor_B1	99,115	GABBR1	117,123	GABA receptor B1	GABBR1	2550	2550	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	MicroRNA-derived network analysis of differentially methylated genes in schizophrenia , implicating GABA_receptor_B1 -LSB- GABBR1 -RSB- and protein_kinase_B -LSB- AKT1 -RSB- .
8164515	0	GABA_transporter	52,68	GAT-1	70,75	GABA transporter	GAT-1	50676(Tax:10116)	50676(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Cellular distribution and regulation by cAMP of the GABA_transporter _ -LRB- GAT-1 -RRB- mRNA .
19346277	0	GABA_transporter-1	91,109	GAT-1	111,116	GABA transporter-1	GAT-1	232333(Tax:10090)	232333(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine , a selective GABA_transporter-1 -LRB- GAT-1 -RRB- inhibitor , coincide with a decrease in HPA system activity in C57BL/6 mice .
9697934	0	GABA_transporter-1	0,18	GAT-1	20,25	GABA transporter-1	GAT-1	6529	6529	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	GABA_transporter-1 -LRB- GAT-1 -RRB- immunoreactivity in the cat periaqueductal gray matter .
17941974	0	GABA_transporter-1	53,71	SLC6A1	78,84	GABA transporter-1	SLC6A1	6529	6529	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence variation and linkage disequilibrium in the GABA_transporter-1 gene -LRB- SLC6A1 -RRB- in five populations : implications for pharmacogenetic research .
9073162	0	GABA_transporter_1	25,43	GAT1	45,49	GABA transporter 1	GAT1	50676(Tax:10116)	50676(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Regional distribution of GABA_transporter_1 -LRB- GAT1 -RRB- mRNA in the rat brain : comparison with glutamic_acid decarboxylase67 -LRB- GAD67 -RRB- mRNA localization .
26450699	0	GABBR1	117,123	GABA_receptor_B1	99,115	GABBR1	GABA receptor B1	2550	2550	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	MicroRNA-derived network analysis of differentially methylated genes in schizophrenia , implicating GABA_receptor_B1 -LSB- GABBR1 -RSB- and protein_kinase_B -LSB- AKT1 -RSB- .
7590737	0	GABPA	42,47	E4TF1-60	49,57	GABPA	E4TF1-60	2551	2551	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping of the human transcription factor GABPA -LRB- E4TF1-60 -RRB- gene to chromosome 21 .
24501276	0	GABPA	38,43	METTL23	0,7	GABPA	METTL23	2551	124512	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	METTL23 , a transcriptional partner of GABPA , is essential for human cognition .
22328717	0	GABP_beta	100,109	BRCA1	86,91	GABP beta	BRCA1	2553	672	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
26442220	0	GABP_beta	112,121	BRCA1	98,103	GABP beta	BRCA1	2553	672	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Commentary : The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
22328717	0	GABP_beta	100,109	glucocorticoid_receptor	15,38	GABP beta	glucocorticoid receptor	2553	2908	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
26442220	0	GABP_beta	112,121	glucocorticoid_receptor	27,50	GABP beta	glucocorticoid receptor	2553	2908	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Commentary : The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
26189305	0	GABRA1	28,34	ABCC2	7,12	GABRA1	ABCC2	2554	1244	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
26189305	0	GABRA1	28,34	SCN1A	14,19	GABRA1	SCN1A	2554	6323	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
26189305	0	GABRA1	28,34	SCN2A	21,26	GABRA1	SCN2A	2554	6326	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
11840313	0	GABRA3	57,63	GABA_receptor	37,50	GABRA3	GABA receptor	2556	11337	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Excess of allele1 for alpha3 subunit GABA_receptor gene -LRB- GABRA3 -RRB- in bipolar patients : a multicentric association study .
14751442	0	GABRA3	94,100	GABA_receptor	74,87	GABRA3	GABA receptor	2556	11337	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of association between polymorphic variations in the alpha 3 subunit GABA_receptor gene -LRB- GABRA3 -RRB- and suicide attempts .
7851879	0	GABRB2	36,42	beta_2	15,21	GABRB2	beta 2	2561	10242	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the beta_2 subunit gene -LRB- GABRB2 -RRB- to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform .
8411721	0	GABRB3	41,47	GABAA_receptor_beta_3-subunit	5,34	GABRB3	GABAA receptor beta 3-subunit	2562	2562	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- The GABAA_receptor_beta_3-subunit gene -LRB- GABRB3 -RRB- as a candidate responsible for central nerve disturbances in Angelman_syndrome -LRB- AS -RRB- -RSB- .
23904086	0	GAD	39,42	Glutamate_Decarboxylase	14,37	GAD	Glutamate Decarboxylase	24957(Tax:10116)	24957(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression of Glutamate_Decarboxylase -LRB- GAD -RRB- mRNA in the brain of bile duct ligated rats serving as a model of hepatic_encephalopathy .
19967454	0	GAD	61,64	Glutamate_decarboxylase	36,59	GAD	Glutamate decarboxylase	831599(Tax:3702)	831599(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation and characterization of a Glutamate_decarboxylase -LRB- GAD -RRB- gene and their differential expression in response to abiotic stresses from Panax ginseng C. A. Meyer .
1516745	0	GAD	63,66	glutamate_decarboxylase	38,61	GAD	glutamate decarboxylase	24957(Tax:10116)	24957(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Transient increase in expression of a glutamate_decarboxylase -LRB- GAD -RRB- mRNA during the postnatal development of the rat striatum .
6329478	0	GAD	50,53	glutamate_decarboxylase	25,48	GAD	glutamate decarboxylase	396489(Tax:9031)	396489(Tax:9031)	Gene	Gene	control|appos|START_ENTITY control|nmod|END_ENTITY	GABA-mediated control of glutamate_decarboxylase -LRB- GAD -RRB- in cell aggregate culture of chick embryo retina .
17767149	0	GAD1	21,25	GAD67	27,32	GAD1	GAD67	2571	2571	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Allelic variation in GAD1 -LRB- GAD67 -RRB- is associated with schizophrenia and influences cortical function and gene expression .
10078545	0	GAD65	47,52	CD4	72,75	GAD65	CD4	2572	920	Gene	Gene	START_ENTITY|acl|mapped mapped|xcomp|using using|dobj|mice mice|compound|END_ENTITY	Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4 , DQA1 * 0301 , DQB1 * 0302 transgenic IA -LRB- null -RRB- NOD mice .
10439311	0	GAD65	102,107	CD4	0,3	GAD65	CD4	2572	920	Gene	Gene	epitopes|compound|START_ENTITY recognize|dobj|epitopes recognize|nsubj|+ +|compound|END_ENTITY	CD4 + and CD8 + T-cell clones from congenital_rubella_syndrome patients with IDDM recognize overlapping GAD65 protein epitopes .
11905849	0	GAD65	100,105	CD4	49,52	GAD65	CD4	2572	920	Gene	Gene	epitopes|nmod|START_ENTITY epitopes|nsubj|Complexity Complexity|nmod|profiles profiles|nmod|cell cell|compound|END_ENTITY	Complexity of human immune response profiles for CD4 + T cell epitopes from the diabetes autoantigen GAD65 .
20370569	0	GAD65	184,189	CD4	159,162	GAD65	CD4	2572	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	A low antigen dose selectively promotes expansion of high-avidity autoreactive T cells with distinct phenotypic characteristics : a study of human autoreactive CD4 + T cells specific for GAD65 .
20503259	0	GAD65	75,80	CD4	20,23	GAD65	CD4	2572	920	Gene	Gene	decarboxylase|appos|START_ENTITY cells|nmod|decarboxylase cells|compound|END_ENTITY	Characterization of CD4 + T cells specific for glutamic_acid decarboxylase -LRB- GAD65 -RRB- and proinsulin in a patient with stiff-person_syndrome but without type_1_diabetes .
23228173	0	GAD65	47,52	CD4	0,3	GAD65	CD4	2572	920	Gene	Gene	epitopes|nmod|START_ENTITY recognize|dobj|epitopes recognize|nsubj|cells cells|compound|END_ENTITY	CD4 + T cells recognize diverse epitopes within GAD65 : implications for repertoire development and diabetes monitoring .
25405480	0	GAD65	119,124	CD4	14,17	GAD65	CD4	2572	920	Gene	Gene	Role|nmod|START_ENTITY Reveals|dobj|Role Reveals|nsubj|Assessment Assessment|nmod|Responses Responses|compound|END_ENTITY	Assessment of CD4 + T Cell Responses to Glutamic_Acid Decarboxylase 65 Using DQ8 Tetramers Reveals a Pathogenic Role of GAD65 121-140 and GAD65 250-266 in T1D Development .
25681349	0	GAD65	40,45	CD4	73,76	GAD65	CD4	2572	920	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	High Diversity in the TCR Repertoire of GAD65 Autoantigen-Specific Human CD4 + T Cells .
26797873	0	GAD65	56,61	CD4	110,113	GAD65	CD4	14417(Tax:10090)	12504(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY containing|dobj|gene plasmid|xcomp|containing DNA|acl|plasmid Vaccination|nmod|DNA Vaccination|nsubj|END_ENTITY	Vaccination with a co-expression DNA plasmid containing GAD65 fragment gene and IL-10 gene induces regulatory CD4 -LRB- + -RRB- T cells that prevent experimental autoimmune diabetes .
19132983	0	GAD65	70,75	FoxP3	7,12	GAD65	FoxP3	2572	50943	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Higher FoxP3 mRNA expression in peripheral blood mononuclear cells of GAD65 or IA-2 autoantibody-positive compared with autoantibody-negative persons .
7808234	0	GAD65	25,30	Glutamate_decarboxylase	0,23	GAD65	Glutamate decarboxylase	2572	2752	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Glutamate_decarboxylase -LRB- GAD65 -RRB- mRNA levels in the striatum and pallidum of MPTP-treated monkeys .
9332731	0	GAD65	25,30	Glutamate_decarboxylase	0,23	GAD65	Glutamate decarboxylase	24380(Tax:10116)	24380(Tax:10116)	Gene	Gene	increased|dep|START_ENTITY increased|nsubjpass|END_ENTITY	Glutamate_decarboxylase -LRB- GAD65 -RRB- gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons .
26780456	0	GAD65	58,63	L-glutamate_Decarboxylase_65_Isoform	20,56	GAD65	L-glutamate Decarboxylase 65 Isoform	2572	2572	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of Brain L-glutamate_Decarboxylase_65_Isoform -LRB- GAD65 -RRB- by Phosphorylation at Threonine 95 -LRB- T95 -RRB- .
22978699	0	GAD65	14,19	SMAR1	34,39	GAD65	SMAR1	14417(Tax:10090)	53325(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment .
8921302	0	GAD65	65,70	glutamate_decarboxylase	4,27	GAD65	glutamate decarboxylase	2572	2752	Gene	Gene	forms|nmod|START_ENTITY forms|amod|END_ENTITY	Two glutamate_decarboxylase forms corresponding to the mammalian GAD65 and GAD67 are expressed during development of the chick telencephalon .
17767149	0	GAD67	27,32	GAD1	21,25	GAD67	GAD1	2571	2571	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Allelic variation in GAD1 -LRB- GAD67 -RRB- is associated with schizophrenia and influences cortical function and gene expression .
9266773	0	GAD67	25,30	Glutamate_decarboxylase	0,23	GAD67	Glutamate decarboxylase	2571	2752	Gene	Gene	increased|dep|START_ENTITY increased|nsubjpass|END_ENTITY	Glutamate_decarboxylase -LRB- GAD67 and GAD65 -RRB- gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian_monkeys .
26812044	0	GAD67	73,78	HDAC1	49,54	GAD67	HDAC1	2571	3065	Gene	Gene	expression|nummod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Toward dissecting the etiology of schizophrenia : HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model .
8453948	0	GAD67	105,110	glutamate_decarboxylase	80,103	GAD67	glutamate decarboxylase	24379(Tax:10116)	24957(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The inferior colliculus of GEPRs contains greater numbers of cells that express glutamate_decarboxylase -LRB- GAD67 -RRB- mRNA .
25091320	0	GAD67	40,45	parvalbumin	60,71	GAD67	parvalbumin	613030(Tax:9544)	697272(Tax:9544)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Regional and age-related differences in GAD67 expression of parvalbumin - and calbindin-expressing neurons in the rhesus_macaque auditory midbrain and brainstem .
11074872	0	GAD67	54,59	reelin	12,18	GAD67	reelin	2571	5649	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Decrease in reelin and glutamic_acid decarboxylase67 -LRB- GAD67 -RRB- expression in schizophrenia and bipolar_disorder : a postmortem brain study .
8898082	0	GADD153	28,35	CHOP	22,26	GADD153	CHOP	1649	1649	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Ectopic expression of CHOP -LRB- GADD153 -RRB- induces apoptosis in M1 myeloblastic_leukemia cells .
17615236	0	GADD153	35,42	CHOP-10	27,34	GADD153	CHOP-10	1649	1649	Gene	Gene	expression|compound|START_ENTITY regulation|dep|expression regulation|nmod|END_ENTITY	Differential regulation of CHOP-10 / GADD153 gene expression by MAPK signaling in pancreatic beta-cells .
21365646	0	GADD153	92,99	alpha_fetoprotein	24,41	GADD153	alpha fetoprotein	1649	174	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Impact of intracellular alpha_fetoprotein on retinoic_acid receptors-mediated expression of GADD153 in human hepatoma cell lines .
16631627	0	GADD153	32,39	focal_adhesion_kinase	56,77	GADD153	focal adhesion kinase	1649	5747	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Doxazosin induces activation of GADD153 and cleavage of focal_adhesion_kinase in cardiomyocytes en route to apoptosis .
8650547	0	GADD153	80,87	p38	92,95	GADD153	p38	1649	1432	Gene	Gene	START_ENTITY|nmod|Kinase Kinase|amod|END_ENTITY	Stress-induced phosphorylation and activation of the transcription factor CHOP -LRB- GADD153 -RRB- by p38 MAP Kinase .
12939601	0	GADD153	60,67	transferrin	40,51	GADD153	transferrin	1649	7018	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells .
17273797	0	GADD34	0,6	mammalian_target_of_rapamycin	16,45	GADD34	mammalian target of rapamycin	23645	2475	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	GADD34 inhibits mammalian_target_of_rapamycin signaling via tuberous_sclerosis_complex and controls cell survival under bioenergetic stress .
17487408	0	GADD34	0,6	p21	15,18	GADD34	p21	171071(Tax:10116)	24525(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	GADD34 induces p21 expression and cellular senescence .
10367887	0	GADD45	13,19	BRCA1	87,92	GADD45	BRCA1	1647	672	Gene	Gene	Induction|nmod|START_ENTITY apoptosis|nsubj|Induction apoptosis|nmod|expression expression|nmod|END_ENTITY	Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1 .
10962562	0	GADD45	24,30	BRCA1	0,5	GADD45	BRCA1	1647	672	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nummod|END_ENTITY	BRCA1 activation of the GADD45 promoter .
11777930	0	GADD45	16,22	BRCA1	0,5	GADD45	BRCA1	1647	672	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs .
8700517	0	GADD45	61,67	PCNA	120,124	GADD45	PCNA	13197(Tax:10090)	18538(Tax:10090)	Gene	Gene	related|nmod|START_ENTITY MyD118|acl|related encodes|nsubj|MyD118 encodes|nmod|protein protein|acl:relcl|interacts interacts|nmod|END_ENTITY	The differentiation primary response gene MyD118 , related to GADD45 , encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1 .
26885618	0	GADD45a	0,7	CDK11p58	31,39	GADD45a	CDK11p58	1647	984	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	GADD45a and y interaction with CDK11p58 regulates SPDEF protein stability and SPDEF-mediated effects on cancer cell migration .
24894488	0	GADD45a	102,109	Hes-1	93,98	GADD45a	Hes-1	1647	3280	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Hes-1 SUMOylation by protein inhibitor of activated STAT1 enhances the suppressing effect of Hes-1 on GADD45a expression to increase cell survival .
23563151	0	GADD45a	48,55	Ribosomal_protein_S7	0,20	GADD45a	Ribosomal protein S7	1647	6201	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ribosomal_protein_S7 regulates arsenite-induced GADD45a expression by attenuating MDM2-mediated GADD45a ubiquitination and degradation .
23563151	0	GADD45a	96,103	Ribosomal_protein_S7	0,20	GADD45a	Ribosomal protein S7	1647	6201	Gene	Gene	ubiquitination|amod|START_ENTITY attenuating|dobj|ubiquitination regulates|advcl|attenuating regulates|nsubj|END_ENTITY	Ribosomal_protein_S7 regulates arsenite-induced GADD45a expression by attenuating MDM2-mediated GADD45a ubiquitination and degradation .
19366794	0	GADD45alpha	105,116	Gonadotropin-releasing_hormone_type_II	0,38	GADD45alpha	Gonadotropin-releasing hormone type II	1647	2797	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Gonadotropin-releasing_hormone_type_II induces apoptosis of human endometrial_cancer cells by activating GADD45alpha .
11429707	0	GADD45alpha	89,100	NF-kappaB	21,30	GADD45alpha	NF-kappaB	1647	4790	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha .
21353395	0	GADD45b	57,64	C/EBPb	109,115	GADD45b	C/EBPb	17873(Tax:10090)	12608(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Senescence of chondrocytes in aging articular cartilage : GADD45b mediates p21 expression in association with C/EBPb in senescence-accelerated mice .
26896926	0	GADD45b	126,133	C/EBPb	34,40	GADD45b	C/EBPb	4616	1051	Gene	Gene	transcription|appos|START_ENTITY regulates|dobj|transcription regulates|nsubj|binding_protein_b binding_protein_b|appos|END_ENTITY	CCAAT/enhancer _ binding_protein_b -LRB- C/EBPb -RRB- regulates the transcription of growth_arrest and DNA damage-inducible protein 45 b -LRB- GADD45b -RRB- in articular chondrocytes .
21353395	0	GADD45b	57,64	p21	74,77	GADD45b	p21	17873(Tax:10090)	12575(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Senescence of chondrocytes in aging articular cartilage : GADD45b mediates p21 expression in association with C/EBPb in senescence-accelerated mice .
23681232	0	GADD45b	0,7	p53	17,20	GADD45b	p53	17873(Tax:10090)	22060(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|degradation degradation|compound|END_ENTITY	GADD45b mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment .
16144844	0	GADD45beta	17,27	MMP-13	45,51	GADD45beta	MMP-13	17873(Tax:10090)	17386(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation .
15797874	0	GADD45beta	55,65	NF-kappaB	0,9	GADD45beta	NF-kappaB	17873(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappaB and not the MAPK signaling pathway regulates GADD45beta expression during acute inflammation .
23038267	0	GADL1	48,53	glutamate_decarboxylase-like_protein_1	8,46	GADL1	glutamate decarboxylase-like protein 1	73748(Tax:10090)	73748(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of glutamate_decarboxylase-like_protein_1 -LRB- GADL1 -RRB- in taurine biosynthesis .
17010654	0	GADS	70,74	SLP-76	91,97	GADS	SLP-76	9402	3937	Gene	Gene	START_ENTITY|nmod|peptide peptide|amod|complex complex|nmod|motif motif|compound|END_ENTITY	Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction .
23687414	0	GAEC1	9,14	CAPN10	25,31	GAEC1	CAPN10	100126794	11132	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Oncogene GAEC1 regulates CAPN10 expression which predicts survival in esophageal_squamous_cell_carcinoma .
12815073	0	GAGA_factor	101,112	Hox	31,34	GAGA factor	Hox	2768981(Tax:7227)	42536(Tax:7227)	Gene	Gene	interactions|nmod|START_ENTITY END_ENTITY|nmod|interactions	Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA_factor .
17113629	0	GAGEC1	0,6	TGF-beta1	73,82	GAGEC1	TGF-beta1	9506	7040	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	GAGEC1 , a cancer/testis associated antigen family member , is a target of TGF-beta1 in age-related prostatic_disease .
15356268	0	GAIP	14,18	GIPC	0,4	GAIP	GIPC	10287	10755	Gene	Gene	START_ENTITY|nsubj|recruits recruits|compound|END_ENTITY	GIPC recruits GAIP -LRB- RGS19 -RRB- to attenuate dopamine_D2_receptor signaling .
25822739	0	GAK	52,55	Cyclin_G_Associated_Kinase	24,50	GAK	Cyclin G Associated Kinase	2580	2580	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|nmod|END_ENTITY	Selective Inhibitors of Cyclin_G_Associated_Kinase -LRB- GAK -RRB- as Anti-Hepatitis_C Agents .
21145487	0	GAKIN	103,108	CARD11	28,34	GAKIN	CARD11	23303	84433	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|distribution distribution|nmod|END_ENTITY	The dynamic distribution of CARD11 at the immunological synapse is regulated by the inhibitory kinesin GAKIN .
23681112	0	GAL-1	12,17	Galectin-1	0,10	GAL-1	Galectin-1	3956	3956	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Galectin-1 -LRB- GAL-1 -RRB- expression is a useful tool to differentiate between_small_cell_osteosarcoma and Ewing_sarcoma .
18595677	0	GAL-R1	55,61	galanin_receptors	36,53	GAL-R1	galanin receptors	101123170	101123170	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of galanin_receptors -LRB- GAL-R1 , GAL-R2 , and GAL-R3 -RRB- on myenteric neurons from the sheep and dog stomach .
10543768	0	GAL1	44,48	Erg11p	18,24	GAL1	Erg11p	852308(Tax:4932)	856398(Tax:4932)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Overexpression of Erg11p by the regulatable GAL1 promoter confers fluconazole resistance in Saccharomyces_cerevisiae .
6374427	0	GAL1	29,33	galactokinase	14,27	GAL1	galactokinase	852308(Tax:4932)	852308(Tax:4932)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of galactokinase -LRB- GAL1 -RRB- enzyme accumulation in Saccharomyces_cerevisiae .
7739564	0	GAL4	0,4	TATA-binding_protein	20,40	GAL4	TATA-binding protein	855828(Tax:4932)	856891(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GAL4 interacts with TATA-binding_protein and coactivators .
7601472	0	GALC	62,66	galactocerebrosidase	40,60	GALC	galactocerebrosidase	2581	2581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and organization of the human galactocerebrosidase -LRB- GALC -RRB- gene .
9441867	0	GALC	70,74	galactocerebrosidase	48,68	GALC	galactocerebrosidase	2581	2581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the 5 ' flanking region of the human galactocerebrosidase -LRB- GALC -RRB- gene .
8908517	0	GALK1	42,47	galactokinase	28,41	GALK1	galactokinase	2584	2584	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Fine structure of the human galactokinase GALK1 gene .
12442278	0	GALNS	162,167	N-acetylgalactosamine-6-sulfate_sulfatase	119,160	GALNS	N-acetylgalactosamine-6-sulfate sulfatase	2588	2588	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular analysis of Turkish mucopolysaccharidosis_IVA -LRB- Morquio A -RRB- patients : identification of novel mutations in the N-acetylgalactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene .
15241807	0	GALNS	130,135	N-acetylgalactosamine-6-sulfate_sulfatase	87,128	GALNS	N-acetylgalactosamine-6-sulfate sulfatase	2588	2588	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mucopolysaccharidosis_IVA -LRB- Morquio A -RRB- : identification of novel common mutations in the N-acetylgalactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene in Italian patients .
8325655	0	GALNS	95,100	N-acetylgalactosamine-6-sulfate_sulfatase	52,93	GALNS	N-acetylgalactosamine-6-sulfate sulfatase	2588	2588	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mucopolysaccharidosis IV A : assignment of the human N-acetylgalactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene to chromosome 16q24 .
8826435	0	GALNS	75,80	galactosamine-6-sulfate_sulfatase	40,73	GALNS	galactosamine-6-sulfate sulfatase	2588	2588	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Heteroallelic missense mutations of the galactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene in a mild form of Morquio_disease -LRB- MPS_IVA -RRB- .
23500900	0	GALNT2	8,14	GALNT2	88,94	GALNT2	GALNT2	2590	2590	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of GALNT2 in the modulation of ENPP1 expression , and insulin signaling and action : GALNT2 : a novel modulator of insulin signaling .
23500900	0	GALNT2	88,94	GALNT2	8,14	GALNT2	GALNT2	2590	2590	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of GALNT2 in the modulation of ENPP1 expression , and insulin signaling and action : GALNT2 : a novel modulator of insulin signaling .
26503214	0	GALNT7	0,6	miR-494	20,27	GALNT7	miR-494	108150(Tax:10090)	723878(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	GALNT7 , a target of miR-494 , participates in the oncogenesis of nasopharyngeal_carcinoma .
10971141	0	GALP	22,26	Galanin-like_peptide	0,20	GALP	Galanin-like peptide	64568(Tax:10116)	64568(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Galanin-like_peptide -LRB- GALP -RRB- mRNA expression is restricted to arcuate_nucleus of hypothalamus in adult male rat brain .
11459819	0	GALP	44,48	galanin-like_peptide	22,42	GALP	galanin-like peptide	64568(Tax:10116)	64568(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Stimulation effect of galanin-like_peptide -LRB- GALP -RRB- on luteinizing hormone-releasing hormone-mediated luteinizing hormone -LRB- LH -RRB- secretion in male rats .
11713207	0	GALP	53,57	galanin-like_peptide	31,51	GALP	galanin-like peptide	232836(Tax:10090)	232836(Tax:10090)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and regulation of galanin-like_peptide -LRB- GALP -RRB- in the hypothalamus of the mouse .
11755241	0	GALP	59,63	galanin-like_peptide	37,57	GALP	galanin-like peptide	64568(Tax:10116)	64568(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of a galanin-like_peptide -LRB- GALP -RRB- in pituicytes of the rat posterior pituitary gland .
16042964	0	GALP	33,37	galanin-like_peptide	11,31	GALP	galanin-like peptide	232836(Tax:10090)	232836(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of galanin-like_peptide -LRB- GALP -RRB- on locomotion , reproduction , and body weight in female and male mice .
12487125	0	GALR1	18,23	galanin	24,31	GALR1	galanin	14427(Tax:10090)	14419(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity .
12487125	0	GALR1	18,23	galanin	44,51	GALR1	galanin	14427(Tax:10090)	14419(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|regulation regulation|compound|END_ENTITY	Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity .
9450684	0	GALR1	0,5	galanin	47,54	GALR1	galanin	50577(Tax:10116)	29141(Tax:10116)	Gene	Gene	mRNA|nummod|START_ENTITY co-expressed|nsubjpass|mRNA co-expressed|nmod|neurons neurons|compound|END_ENTITY	GALR1 galanin receptor mRNA is co-expressed by galanin neurons but not cholinergic neurons in the rat basal forebrain .
9450684	0	GALR1	0,5	galanin	6,13	GALR1	galanin	50577(Tax:10116)	29141(Tax:10116)	Gene	Gene	mRNA|nummod|START_ENTITY mRNA|amod|END_ENTITY	GALR1 galanin receptor mRNA is co-expressed by galanin neurons but not cholinergic neurons in the rat basal forebrain .
11900829	0	GALR1	34,39	galanin_receptor-1	14,32	GALR1	galanin receptor-1	50577(Tax:10116)	50577(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of galanin_receptor-1 -LRB- GALR1 -RRB- in the rat trigeminal ganglia and molar teeth .
15899880	0	GALR2	70,75	galanin	52,59	GALR2	galanin	14428(Tax:10090)	14419(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Phenotypic analysis of mice deficient_in_the_type_2 galanin receptor -LRB- GALR2 -RRB- .
23319291	0	GALT	17,21	Cryptic	0,7	GALT	Cryptic	2592	55997	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Cryptic residual GALT activity is a potential modifier of scholastic outcome in school age children with classic_galactosemia .
19079226	0	GALT	7,11	Foxp3	24,29	GALT	Foxp3	2592	50943	Gene	Gene	DCs|compound|START_ENTITY promote|nsubj|DCs promote|dobj|cells cells|amod|END_ENTITY	CD103 + GALT DCs promote Foxp3 + regulatory T cells .
10408771	0	GALT	86,90	galactose-1-phosphate_uridyl_transferase	44,84	GALT	galactose-1-phosphate uridyl transferase	2592	2592	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Classical_galactosemia and mutations at the galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene .
12521227	0	GALT	122,126	galactose-1-phosphate_uridyl_transferase	80,120	GALT	galactose-1-phosphate uridyl transferase	2592	2592	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequencies of Q188R and N314D mutations and IVS5-24g > A intron variation in the galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene in the Slovenian population .
17079880	0	GALT	89,93	galactose-1-phosphate_uridyl_transferase	47,87	GALT	galactose-1-phosphate uridyl transferase	2592	2592	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of an unusual deletion of the galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene .
21188552	0	GALT	139,143	galactose-1-phosphate_uridyl_transferase	97,137	GALT	galactose-1-phosphate uridyl transferase	2592	2592	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A case of classical_galactosemia : identification and characterization of 3 distinct mutations in galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene in a single family .
10220154	0	GALT	76,80	galactose-1-phosphate_uridyltransferase	35,74	GALT	galactose-1-phosphate uridyltransferase	2592	2592	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of mutations in the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene in 16 Turkish patients with galactosemia , including a novel mutation of F294Y .
17486650	0	GALT	67,71	galactose-1-phosphate_uridyltransferase	26,65	GALT	galactose-1-phosphate uridyltransferase	2592	2592	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation database for the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene .
25592817	0	GALT	212,216	galactose-1-phosphate_uridyltransferase	171,210	GALT	galactose-1-phosphate uridyltransferase	2592	2592	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical and molecular spectra in galactosemic patients from neonatal screening in northeastern Italy : Structural and functional characterization of new variations in the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene .
26043515	0	GALT	68,72	galactose-1-phosphate_uridyltransferase	27,66	GALT	galactose-1-phosphate uridyltransferase	104914764	104914764	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene in southeast part of Turkey : a regional report .
18454942	0	GALT	99,103	lactase	27,34	GALT	lactase	2592	3938	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Synergistic effect of high lactase activity genotype and galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- mutations on idiopathic presenile cataract formation .
16293431	0	GAMT	60,64	guanidinoacetate_methyltransferase	24,58	GAMT	guanidinoacetate methyltransferase	2593	2593	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A mutation on exon 6 of guanidinoacetate_methyltransferase -LRB- GAMT -RRB- gene supports a different function for isoform a and b of GAMT enzyme .
19181385	0	GANP	0,4	PRMT5	47,52	GANP	PRMT5	54387(Tax:10090)	27374(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells .
16431081	0	GANP	68,72	germinal_center-associated_nuclear_protein	24,66	GANP	germinal center-associated nuclear protein	8888	8888	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of germinal_center-associated_nuclear_protein -LRB- GANP -RRB- is associated with malignant_transformation_of_melanocytes .
10708762	0	GAP	89,92	p120	84,88	GAP	p120	1500	1500	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Identification of a novel protein complex containing annexin_VI , Fyn , Pyk2 , and the p120 -LRB- GAP -RRB- C2 domain .
2574500	0	GAP	107,110	p21	76,79	GAP	p21	29127	644914	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Chromosome localization and cDNA sequence of murine and human genes for ras p21 GTPase activating protein -LRB- GAP -RRB- .
2842690	0	GAP	18,21	p21	61,64	GAP	p21	282032(Tax:9913)	338049(Tax:9913)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of bovine GAP and its interaction with oncogenic ras p21 .
10640691	0	GAP-43	104,110	B-50	99,103	GAP-43	B-50	14432(Tax:10090)	14432(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transgenic expression of B-50 / GAP-43 in mature olfactory neurons triggers downregulation of native B-50 / GAP-43 expression in immature olfactory neurons .
1840422	0	GAP-43	43,49	B-50	38,42	GAP-43	B-50	2596	2596	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of the growth-associated protein B-50 / GAP-43 in neuronal plasticity .
2466968	0	GAP-43	53,59	B-50	61,65	GAP-43	B-50	2596	2596	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the growth-associated phosphoprotein GAP-43 -LRB- B-50 , F1 -RRB- in the human cerebral cortex .
2926454	0	GAP-43	50,56	B-50	44,48	GAP-43	B-50	2596	2596	Gene	Gene	light|appos|START_ENTITY light|nmod|END_ENTITY	A light and electron microscopical study of B-50 -LRB- GAP-43 -RRB- in human intramuscular nerve and neuromuscular junctions during development .
8512206	0	GAP-43	23,29	B-50	18,22	GAP-43	B-50	2596	2596	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	The expression of B-50 / GAP-43 in Schwann cells .
8613733	0	GAP-43	58,64	B-50	53,57	GAP-43	B-50	14432(Tax:10090)	14432(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Directed expression of the growth-associated protein B-50 / GAP-43 to olfactory neurons in transgenic_mice results in changes in axon morphology and extraglomerular fiber growth .
9089204	0	GAP-43	44,50	Brain-derived_neurotrophic_factor	0,33	GAP-43	Brain-derived neurotrophic factor	29423(Tax:10116)	24225(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor modulates GAP-43 but not T alpha1 expression in injured retinal_ganglion cells of adult rats .
21822733	0	GAP-43	46,52	ERK1/2	14,20	GAP-43	ERK1/2	29423(Tax:10116)	50689;116590	Gene	Gene	expression|compound|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
9718977	0	GAP-43	30,36	Growth_associated_protein_43	0,28	GAP-43	Growth associated protein 43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Growth_associated_protein_43 -LRB- GAP-43 -RRB- mRNA is upregulated in the rat superior cervical ganglia after preganglionic transection .
21822733	0	GAP-43	46,52	IGF-1	37,42	GAP-43	IGF-1	29423(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
10640639	0	GAP-43	23,29	P19	33,36	GAP-43	P19	14432(Tax:10090)	83430(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Targeted disruption of GAP-43 in P19 embryonal_carcinoma cells inhibits neuronal differentiation .
19332125	0	GAP-43	31,37	Prolyl_oligopeptidase	0,21	GAP-43	Prolyl oligopeptidase	14432(Tax:10090)	19072(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Prolyl_oligopeptidase binds to GAP-43 and functions without its peptidase activity .
7808229	0	GAP-43	81,87	S100_beta	91,100	GAP-43	S100 beta	2596	6285	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of protein_kinase_C - and casein_kinase_II-mediated phosphorylation of GAP-43 by S100_beta .
11124896	0	GAP-43	16,22	bFGF	0,4	GAP-43	bFGF	2596	2247	Gene	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	bFGF stimulates GAP-43 phosphorylation at ser41 and modifies its intracellular localization in cultured hippocampal neurons .
20335141	0	GAP-43	59,65	brain_derived_neurotrophic_factor	22,55	GAP-43	brain derived neurotrophic factor	29423(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of endogenous brain_derived_neurotrophic_factor on GAP-43 expression in the anterior horn of the spinal cord in rats with sciatic_nerve_injury -RSB- .
12631465	0	GAP-43	74,80	growth-associated_phosphoprotein	40,72	GAP-43	growth-associated phosphoprotein	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Influence of peripheral inflammation on growth-associated_phosphoprotein -LRB- GAP-43 -RRB- expression in dorsal root ganglia and on nerve recovery after crush injury .
1333338	0	GAP-43	54,60	growth-associated_protein	27,52	GAP-43	growth-associated protein	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Differential expression of growth-associated_protein -LRB- GAP-43 -RRB- mRNA in rat primary sensory neurons after peripheral_nerve_lesion : a non-radioactive in situ hybridisation study .
7907951	0	GAP-43	64,70	growth-associated_protein	37,62	GAP-43	growth-associated protein	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of a growth-associated_protein -LRB- GAP-43 -RRB- in rat adrenal gland .
9355109	0	GAP-43	56,62	growth-associated_protein	30,55	GAP-43	growth-associated protein	2596	2596	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Gonadal steroid regulation of growth-associated_protein GAP-43 mRNA expression in axotomized hamster facial motor neurons .
8859903	0	GAP-43	70,76	growth-associated_protein_43	40,68	GAP-43	growth-associated protein 43	493873(Tax:9685)	493873(Tax:9685)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Long-term effects of retinal lesions on growth-associated_protein_43 -LRB- GAP-43 -RRB- expression in the visual system of adult cats .
1661809	0	GAP-43	78,84	growth-associated_protein_43_kDa	44,76	GAP-43	growth-associated protein 43 kDa	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Estrogenic regulation and sex dimorphism of growth-associated_protein_43_kDa -LRB- GAP-43 -RRB- messenger RNA in the rat .
11374816	0	GAP-43	43,49	growth_associated_protein	16,41	GAP-43	growth associated protein	100623423	100623423	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of growth_associated_protein -LRB- GAP-43 -RRB- immunoreactivity in nerve fibers supplying the pig pineal gland .
10936192	0	GAP-43	72,78	nerve_growth_factor	149,168	GAP-43	nerve growth factor	29423(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nmod|absence absence|nmod|END_ENTITY	Overexpression of HuD , but not of its truncated form HuD I+II , promotes GAP-43 gene expression and neurite outgrowth in PC12 cells in the absence of nerve_growth_factor .
11703425	0	GAP-43	48,54	nerve_growth_factor	11,30	GAP-43	nerve growth factor	29423(Tax:10116)	310738(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nerve_growth_factor on expression of GAP-43 in right atria after sympathectomy in diabetic rats .
2461937	0	GAP-43	19,25	nerve_growth_factor	45,64	GAP-43	nerve growth factor	29423(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Dual regulation of GAP-43 gene expression by nerve_growth_factor and glucocorticoids .
1837850	0	GAP-43	36,42	protein_F1	24,34	GAP-43	protein F1	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Selective expression of protein_F1 / -LRB- GAP-43 -RRB- mRNA in pyramidal but not granule cells of the hippocampus .
7613626	0	GAP-43	63,69	protein_kinase_C	11,27	GAP-43	protein kinase C	29423(Tax:10116)	24681(Tax:10116)	Gene	Gene	START_ENTITY|dep|Changes Changes|nmod|END_ENTITY	Changes in protein_kinase_C and its presynaptic substrate B-50 / GAP-43 after intrauterine exposure to methylazoxy-methanol , a treatment inducing cortical and hippocampal_damage and cognitive_deficit in rats .
9139733	0	GAP-43	52,58	protein_kinase_C-delta	82,104	GAP-43	protein kinase C-delta	2596	5580	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Regulated binding of the protein kinase C substrate GAP-43 to the V0/C2 region of protein_kinase_C-delta .
2552034	0	GAP43	46,51	growth-associated_protein_B-50	14,44	GAP43	growth-associated protein B-50	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of growth-associated_protein_B-50 -LRB- GAP43 -RRB- in dorsal root ganglia and sciatic nerve during regenerative sprouting .
2149862	0	GAP43	44,49	p38	69,72	GAP43	p38	29423(Tax:10116)	81649(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural double localization of B-50 / GAP43 and synaptophysin -LRB- p38 -RRB- in the neonatal and adult rat hippocampus .
10202141	0	GAPCenA	20,27	Rab6	61,65	GAPCenA	Rab6	23637	5870	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Characterization of GAPCenA , a GTPase activating protein for Rab6 , part of which associates with the centrosome .
23645209	0	GAPDH	0,5	Akt	22,25	GAPDH	Akt	2597	207	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	GAPDH binds to active Akt , leading to Bcl-xL increase and escape from caspase-independent cell death .
23653351	0	GAPDH	42,47	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	2597	2597	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- phosphorylation by protein_kinase_C -LRB- PKC -RRB- inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury .
11821985	0	GAPDH	69,74	HPRT	132,136	GAPDH	HPRT	100009074(Tax:9986)	100126071(Tax:9986)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Differential expression of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- , beta actin and hypoxanthine_phosphoribosyltransferase _ -LRB- HPRT -RRB- _ in_postnatal_rabbit_sclera .
8612237	0	GAPDH	67,72	Huntingtin	0,10	GAPDH	Huntingtin	2597	3064	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|proteins proteins|compound|END_ENTITY	Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH .
26626483	0	GAPDH	34,39	Sirt1	49,54	GAPDH	Sirt1	2597	23411	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation .
11792468	0	GAPDH	69,74	glyceraldehyde-3-phosphate_dehydrogenase	27,67	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	2597	2597	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Differential alteration of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- mRNA in the central nervous system of hens treated with diisopropylphosphorofluoridate -LRB- DFP -RRB- .
11821985	0	GAPDH	69,74	glyceraldehyde-3-phosphate_dehydrogenase	27,67	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	100009074(Tax:9986)	100009074(Tax:9986)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- , beta actin and hypoxanthine_phosphoribosyltransferase _ -LRB- HPRT -RRB- _ in_postnatal_rabbit_sclera .
11891433	0	GAPDH	55,60	glyceraldehyde-3-phosphate_dehydrogenase	13,53	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	24383(Tax:10116)	24383(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- expression in rat brain after focal ischemia/reperfusion .
19123030	0	GAPDH	66,71	glyceraldehyde-3-phosphate_dehydrogenase	24,64	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	2597	2597	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- gene from the halotolerant alga Dunaliella_salina and inhibition of its expression by RNAi .
20586183	0	GAPDH	100,105	glyceraldehyde-3-phosphate_dehydrogenase	53,93	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	100478741	100478741	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	cDNA , genomic sequence cloning and overexpression of glyceraldehyde-3-phosphate_dehydrogenase gene -LRB- GAPDH -RRB- from the Giant_Panda .
22371187	0	GAPDH	50,55	glyceraldehyde-3-phosphate_dehydrogenase	8,48	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	2597	2597	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	A novel glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- promoter for expressing transgenes in the halotolerant alga Dunaliella_salina .
23086952	0	GAPDH	78,83	glyceraldehyde-3-phosphate_dehydrogenase	36,76	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	2597	2597	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Human and pneumococcal cell surface glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- proteins are both ligands of human C1q protein .
19140804	0	GAPDH	0,5	hexokinase-II	34,47	GAPDH	hexokinase-II	2597	3099	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity .
23091630	0	GAPDH	80,85	miR-644a	114,122	GAPDH	miR-644a	2597	693229	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	Housekeeping gene selection advisory : glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- and b-actin are targets of miR-644a .
10531467	0	GAPDH	109,114	p53	133,136	GAPDH	p53	24383(Tax:10116)	301300(Tax:10116)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Involvement of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- and p53 in neuronal apoptosis : evidence that GAPDH is upregulated by p53 .
19509291	0	GAREM	0,5	growth_factor_receptor-bound_protein_2	35,73	GAREM	growth factor receptor-bound protein 2	64762	2885	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	GAREM , a novel adaptor protein for growth_factor_receptor-bound_protein_2 , contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling .
24768767	0	GARNL1	0,6	RalA	82,86	GARNL1	RalA	253959	5898	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	GARNL1 , a major RalGAP a subunit in skeletal muscle , regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins .
23423978	0	GARP	22,26	CTLA-4	29,35	GARP	CTLA-4	1258	1493	Gene	Gene	Foxp3|amod|START_ENTITY Foxp3|amod|END_ENTITY	Higher frequencies of GARP -LRB- + -RRB- CTLA-4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T regulatory cells and myeloid-derived suppressor cells in hepatocellular_carcinoma patients are associated with impaired T-cell functionality .
20660722	0	GARP	116,120	Golgi-associated_retrograde_protein	79,114	GARP	Golgi-associated retrograde protein	2615	2615	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated_retrograde_protein -LRB- GARP -RRB- complex to a family of tethering complexes .
20642442	1	GARP	48,52	LRRC32	54,60	GARP	LRRC32	2615	2615	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	the role of GARP -LRB- LRRC32 -RRB- as a safeguard of the regulatory phenotype .
25127859	0	GARP	48,52	TGF-b1	41,47	GARP	TGF-b1	235505(Tax:10090)	21803(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Release of active TGF-b1 from the latent TGF-b1 / GARP complex on T regulatory cells is mediated by integrin_b8 .
19651619	0	GARP	0,4	TGF-beta	64,72	GARP	TGF-beta	2615	7040	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|expression expression|nmod|END_ENTITY	GARP -LRB- LRRC32 -RRB- is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3 + regulatory T cells .
19750484	0	GARP	17,21	TGF-beta	47,55	GARP	TGF-beta	2615	7040	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg .
22278742	0	GARP	0,4	TGFb	53,57	GARP	TGFb	2615	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|bioavailability bioavailability|nmod|END_ENTITY	GARP regulates the bioavailability and activation of TGFb .
27054568	0	GARP	12,16	TGFb	26,30	GARP	TGFb	2615	7040	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	How Soluble GARP Enhances TGFb Activation .
20615984	0	GARP	113,117	Vps54	92,97	GARP	Vps54	434215(Tax:10090)	245944(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex subunit|amod|END_ENTITY	Structural basis for the wobbler mouse neurodegenerative_disorder caused by mutation in the Vps54 subunit of the GARP complex .
19412816	0	GARS	47,51	glycyl-tRNA_synthetase	23,45	GARS	glycyl-tRNA synthetase	2617	2617	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of glycyl-tRNA_synthetase -LRB- GARS -RRB- gene in Hirayama_disease .
26000875	0	GARS	48,52	glycyl-tRNA_synthetase	24,46	GARS	glycyl-tRNA synthetase	2617	2617	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation of the glycyl-tRNA_synthetase -LRB- GARS -RRB- gene associated with Charcot-Marie-Tooth_type_2D in a Chinese family .
26805687	0	GAS1	71,75	MiR-184	0,7	GAS1	MiR-184	2619	406960	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-184 regulates proliferation in nucleus pulposus cells by targeting GAS1 .
24220341	0	GAS1	16,20	MiR-34a	0,7	GAS1	MiR-34a	2619	407040	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary_thyroid_carcinoma via PI3K/Akt/Bad pathway .
11756182	0	GAS41	34,39	AF10	23,27	GAS41	AF10	8089	8028	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The MLL fusion partner AF10 binds GAS41 , a protein that interacts with the human SWI/SNF complex .
16698963	0	GAS41	0,5	AP-2beta	42,50	GAS41	AP-2beta	8089	7021	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation .
10913114	0	GAS41	0,5	NuMA	65,69	GAS41	NuMA	8089	4926	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	GAS41 , a highly conserved protein in eukaryotic nuclei , binds to NuMA .
20618999	0	GAS41	24,29	TFIIF	78,83	GAS41	TFIIF	8089	2962	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The YEATS family member GAS41 interacts with the general transcription factor TFIIF .
26550436	0	GAS5	72,76	Notch-1	0,7	GAS5	Notch-1	60674	4851	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Notch-1 promotes breast_cancer cells proliferation by regulating LncRNA GAS5 .
25197831	0	GAS5	24,28	eukaryotic_translation_initiation_factor_4E	49,92	GAS5	eukaryotic translation initiation factor 4E	60674	1977	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The long non-coding RNA GAS5 cooperates with the eukaryotic_translation_initiation_factor_4E to regulate c-Myc translation .
9287338	0	GAS6	0,4	Axl	72,75	GAS6	Axl	2621	558	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|adhesion adhesion|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	GAS6 mediates adhesion of cells expressing the receptor_tyrosine_kinase Axl .
9357964	0	GAS6	0,4	Axl	20,23	GAS6	Axl	2621	558	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|receptors receptors|compound|END_ENTITY	GAS6 , the ligand of Axl and Rse receptors , is expressed in hematopoietic tissue but lacks mitogenic activity .
23571515	0	GAS6	26,30	Growth-arrest-specific_6	0,24	GAS6	Growth-arrest-specific 6	2621	2621	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Growth-arrest-specific_6 -LRB- GAS6 -RRB- protein in ARDS patients : determination of plasma levels and influence of PEEP setting .
19369636	0	GAS6	42,46	growth_arrest-specific_6	16,40	GAS6	growth arrest-specific 6	2621	2621	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Plasma level of growth_arrest-specific_6 -LRB- GAS6 -RRB- protein and genetic variations in the GAS6 gene in patients with acute_coronary_syndrome .
10400186	0	GAS6	49,53	growth_arrest-specific_gene_6	18,47	GAS6	growth arrest-specific gene 6	2621	2621	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the growth_arrest-specific_gene_6 -LRB- GAS6 -RRB- in leukemia and lymphoma cell lines .
18360812	0	GAS6	89,93	growth_arrest_specific_6	63,87	GAS6	growth arrest specific 6	2621	2621	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Development and validation of an ELISA method for detection of growth_arrest_specific_6 -LRB- GAS6 -RRB- protein in human plasma .
17471240	0	GASDERMIN	0,9	LMO1	67,71	GASDERMIN	LMO1	284110	4004	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	GASDERMIN , suppressed frequently in gastric_cancer , is a target of LMO1 in TGF-beta-dependent apoptotic signalling .
24019467	0	GASP-1	47,53	GDF-11	14,20	GASP-1	GDF-11	278507(Tax:10090)	14561(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2 .
4857865	2	GAT	135,138	L-glutamic_acid_60-L-alanine30-L-tyrosine10	90,133	GAT	L-glutamic acid 60-L-alanine30-L-tyrosine10	107146(Tax:10090)	107146(Tax:10090)	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Tolerogenic properties of the terpolymer L-glutamic_acid_60-L-alanine30-L-tyrosine10 -LRB- GAT -RRB- for spleen cells from nonresponder -LRB- H-2s and H-2q -RRB- mice .
8164515	0	GAT-1	70,75	GABA_transporter	52,68	GAT-1	GABA transporter	50676(Tax:10116)	50676(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Cellular distribution and regulation by cAMP of the GABA_transporter _ -LRB- GAT-1 -RRB- mRNA .
19346277	0	GAT-1	111,116	GABA_transporter-1	91,109	GAT-1	GABA transporter-1	232333(Tax:10090)	232333(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine , a selective GABA_transporter-1 -LRB- GAT-1 -RRB- inhibitor , coincide with a decrease in HPA system activity in C57BL/6 mice .
9697934	0	GAT-1	20,25	GABA_transporter-1	0,18	GAT-1	GABA transporter-1	6529	6529	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	GABA_transporter-1 -LRB- GAT-1 -RRB- immunoreactivity in the cat periaqueductal gray matter .
9073162	0	GAT1	45,49	GABA_transporter_1	25,43	GAT1	GABA transporter 1	50676(Tax:10116)	50676(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Regional distribution of GABA_transporter_1 -LRB- GAT1 -RRB- mRNA in the rat brain : comparison with glutamic_acid decarboxylase67 -LRB- GAD67 -RRB- mRNA localization .
18005670	0	GATA	33,37	NOX1	14,18	GATA	NOX1	55278	27035	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regulation of NOX1 expression by GATA , HNF-1alpha , and Cdx transcription factors .
15680371	0	GATA	21,25	dGATAe	39,45	GATA	dGATAe	42283(Tax:7227)	41945(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	An endoderm-specific GATA factor gene , dGATAe , is required for the terminal differentiation of the Drosophila endoderm .
12041667	0	GATA	0,4	erythropoietin	16,30	GATA	erythropoietin	76563(Tax:10090)	13856(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter .
12041667	0	GATA	55,59	erythropoietin	74,88	GATA	erythropoietin	76563(Tax:10090)	13856(Tax:10090)	Gene	Gene	site|compound|START_ENTITY site|nmod|promoter promoter|compound|END_ENTITY	GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter .
12686473	0	GATA	102,106	glucose-dependent_insulinotropic_polypeptide	32,76	GATA	glucose-dependent insulinotropic polypeptide	76563(Tax:10090)	14607(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Cell-specific expression of the glucose-dependent_insulinotropic_polypeptide gene functions through a GATA and an ISL-1 motif in a mouse neuroendocrine_tumor cell line .
22240895	0	GATA-1	70,76	ABC-me	30,36	GATA-1	ABC-me	14460(Tax:10090)	56199(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	The mitochondrial transporter ABC-me -LRB- ABCB10 -RRB- , a downstream target of GATA-1 , is essential for erythropoiesis in vivo .
21041734	0	GATA-1	20,26	CCR3	30,34	GATA-1	CCR3	2623	1232	Gene	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	The crucial role of GATA-1 in CCR3 gene transcription : modulated balance by multiple GATA elements in the CCR3 regulatory region .
16091457	0	GATA-1	21,27	CCR5	86,90	GATA-1	CCR5	2623	1234	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells .
21614864	0	GATA-1	94,100	CD34	104,108	GATA-1	CD34	2623	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Simulated microgravity , erythroid differentiation , and the expression of transcription factor GATA-1 in CD34 + cells .
16648487	0	GATA-1	35,41	CP2	26,29	GATA-1	CP2	2623	1356	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of CP2 with GATA-1 in the regulation of erythroid promoters .
10207073	0	GATA-1	67,73	CREB-Binding_protein	0,20	GATA-1	CREB-Binding protein	2623	1387	Gene	Gene	acetylates|dobj|START_ENTITY acetylates|nsubj|END_ENTITY	CREB-Binding_protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites .
9482838	0	GATA-1	58,64	CREB-binding_protein	0,20	GATA-1	CREB-binding protein	14460(Tax:10090)	12914(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	CREB-binding_protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation .
17332341	0	GATA-1	0,6	ERK2	114,118	GATA-1	ERK2	2623	5594	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells .
8510925	0	GATA-1	19,25	ETS1	40,44	GATA-1	ETS1	396450(Tax:9031)	396235(Tax:9031)	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Transactivation of GATA-1 promoter with ETS1 , ETS2 and ERGB/Hu-FLI -1 proteins : stabilization of the ETS1 protein binding on GATA-1 promoter sequences by monoclonal antibody .
16204311	0	GATA-1	60,66	Erythropoietin	0,14	GATA-1	Erythropoietin	2623	2056	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway .
11342429	0	GATA-1	117,123	GATA-1	98,104	GATA-1	GATA-1	14460(Tax:10090)	14460(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression -LRB- GATA-1 -LRB- low -RRB- mice -RRB- .
11342429	0	GATA-1	98,104	GATA-1	117,123	GATA-1	GATA-1	14460(Tax:10090)	14460(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Accentuated response to phenylhydrazine and erythropoietin in mice genetically impaired for their GATA-1 expression -LRB- GATA-1 -LRB- low -RRB- mice -RRB- .
14695898	0	GATA-1	32,38	GATA-1	52,58	GATA-1	GATA-1	2623	2623	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Context-dependent regulation of GATA-1 by friend of GATA-1 .
14695898	0	GATA-1	52,58	GATA-1	32,38	GATA-1	GATA-1	2623	2623	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Context-dependent regulation of GATA-1 by friend of GATA-1 .
14668799	0	GATA-1	34,40	HDAC5	23,28	GATA-1	HDAC5	14460(Tax:10090)	15184(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation .
18586828	0	GATA-1	38,44	HS2	66,69	GATA-1	HS2	2623	6710	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of transcriptional activator GATA-1 at human beta-globin HS2 .
20410505	0	GATA-1	15,21	HSP27	0,5	GATA-1	HSP27	2623	3315	Gene	Gene	level|compound|START_ENTITY controls|dobj|level controls|nsubj|END_ENTITY	HSP27 controls GATA-1 protein level during erythroid cell differentiation .
16650898	0	GATA-1	106,112	IL-9	58,62	GATA-1	IL-9	14460(Tax:10090)	16198(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1 .
22346774	0	GATA-1	15,21	NDRG2	0,5	GATA-1	NDRG2	2623	57447	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells .
26296469	0	GATA-1	0,6	Nanog	26,31	GATA-1	Nanog	14460(Tax:10090)	71950(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GATA-1 directly regulates Nanog in mouse embryonic stem cells .
26296469	0	GATA-1	0,6	Nanog	26,31	GATA-1	Nanog	14460(Tax:10090)	71950(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GATA-1 directly regulates Nanog in mouse embryonic stem cells .
7739528	0	GATA-1	83,89	Sp1	124,127	GATA-1	Sp1	2623	6667	Gene	Gene	synergy|nmod|START_ENTITY synergy|nmod|END_ENTITY	Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kr ppel family proteins Sp1 and EKLF .
9168923	0	GATA-1	42,48	coproporphyrinogen_oxidase	80,106	GATA-1	coproporphyrinogen oxidase	14460(Tax:10090)	12892(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the transcriptional factor GATA-1 in regulation of expression of coproporphyrinogen_oxidase in mouse_erythroleukemia cells .
1660143	0	GATA-1	75,81	erythropoietin	18,32	GATA-1	erythropoietin	2623	2056	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|promoter promoter|compound|END_ENTITY	Activation of the erythropoietin receptor promoter by transcription factor GATA-1 .
7760810	0	GATA-1	66,72	estrogen_receptor	80,97	GATA-1	estrogen receptor	2623	2099	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen_receptor .
14623254	0	GATA-1	78,84	glutathione_S-transferase_P1-1	14,44	GATA-1	glutathione S-transferase P1-1	2623	2950	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of glutathione_S-transferase_P1-1 in differentiating K562 : role of GATA-1 .
21304100	0	GATA-1	123,129	mTOR	105,109	GATA-1	mTOR	2623	21977(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes .
20495378	0	GATA-1	0,6	p21	26,29	GATA-1	p21	2623	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	GATA-1 directly regulates p21 gene expression during erythroid differentiation .
23028422	0	GATA-2	76,82	CD34	92,96	GATA-2	CD34	2624	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34 + hematopoietic cells .
18246306	0	GATA-2	64,70	CREB-binding_proteins	0,21	GATA-2	CREB-binding proteins	2624	1387	Gene	Gene	coactivator|nmod|START_ENTITY END_ENTITY|nmod|coactivator	CREB-binding_proteins -LRB- CBP -RRB- as a transcriptional coactivator of GATA-2 .
11964310	0	GATA-2	16,22	FAZF	97,101	GATA-2	FAZF	2624	27033	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Interactions of GATA-2 with the promyelocytic_leukemia_zinc_finger -LRB- PLZF -RRB- protein , its homologue FAZF , and the t -LRB- 11 ; 17 -RRB- - generated PLZF-retinoic_acid receptor alpha oncoprotein .
18452556	0	GATA-2	83,89	TGF-b	108,113	GATA-2	TGF-b	14461(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Evi-1 promotes para-aortic splanchnopleural_hematopoiesis through up-regulation of GATA-2 and repression of TGF-b signaling .
11169463	0	GATA-2	15,21	erythropoietin	89,103	GATA-2	erythropoietin	2624	2056	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|expression expression|compound|END_ENTITY	Stimulation of GATA-2 as a mechanism of hydrogen_peroxide suppression in hypoxia-induced erythropoietin gene expression .
10906066	0	GATA-2	0,6	prolactin-like_protein_A	17,41	GATA-2	prolactin-like protein A	14461(Tax:10090)	19110(Tax:10090)	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|expression expression|amod|END_ENTITY	GATA-2 restricts prolactin-like_protein_A expression to secondary trophoblast giant cells in the mouse .
17479196	0	GATA-2	17,23	tissue_factor_pathway_inhibitor	73,104	GATA-2	tissue factor pathway inhibitor	2624	7035	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Crucial roles of GATA-2 and SP1 in adrenomedullin-affected expression of tissue_factor_pathway_inhibitor in human umbilical vein endothelial cells exposed to lipopolysaccharide .
24509415	0	GATA-2	0,6	transforming_growth_factor-b	16,44	GATA-2	transforming growth factor-b	2624	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	GATA-2 inhibits transforming_growth_factor-b signaling pathway through interaction with Smad4 .
15947486	0	GATA-3	8,14	CD4	45,48	GATA-3	CD4	2625	920	Gene	Gene	Role|nmod|START_ENTITY transcription|nsubj|Role transcription|nmod|cells cells|nummod|END_ENTITY	Role of GATA-3 in IL-5 gene transcription by CD4 + T cells of asthmatic patients .
18776904	0	GATA-3	49,55	CD4	104,107	GATA-3	CD4	2625	920	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|differentiation differentiation|nmod|END_ENTITY	Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4 -LRB- + -RRB- T cells .
21357543	0	GATA-3	14,20	CD4	39,42	GATA-3	CD4	2625	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of GATA-3 expression during CD4 lineage differentiation .
21625544	0	GATA-3	47,53	CD4	13,16	GATA-3	CD4	14462(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY Expansion|appos|cells Expansion|nmod|CD25 CD25|compound|END_ENTITY	Expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- and CD25 -LRB- - -RRB- T-Bet , GATA-3 , Foxp3 and RORyt cells in allergic_inflammation , local lung distribution and chemokine gene expression .
24099613	0	GATA-3	70,76	CD4	52,55	GATA-3	CD4	2625	920	Gene	Gene	deficient|nsubj|START_ENTITY cells|ccomp|deficient cells|compound|END_ENTITY	All-transretinoic_acid regulates Th1/Th2 balance in CD4 + T cells when GATA-3 is deficient .
9160750	0	GATA-3	25,31	CD4	96,99	GATA-3	CD4	14462(Tax:10090)	12504(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells .
16476055	0	GATA-3	42,48	Cytotoxic_T-lymphocyte_antigen-4	0,32	GATA-3	Cytotoxic T-lymphocyte antigen-4	14462(Tax:10090)	12477(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Cytotoxic_T-lymphocyte_antigen-4 inhibits GATA-3 but not T-bet mRNA expression during T helper cell differentiation .
10227805	0	GATA-3	0,6	IFN-gamma	35,44	GATA-3	IFN-gamma	2625	3458	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|production production|amod|END_ENTITY	GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels .
15947486	0	GATA-3	8,14	IL-5	18,22	GATA-3	IL-5	2625	3567	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Role of GATA-3 in IL-5 gene transcription by CD4 + T cells of asthmatic patients .
9780145	0	GATA-3	79,85	IL-5	35,39	GATA-3	IL-5	2625	3567	Gene	Gene	transcription|dobj|START_ENTITY responsiveness|acl|transcription responsiveness|nmod|genes genes|compound|END_ENTITY	Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3 .
11893731	0	GATA-3	47,53	Interleukin-13	0,14	GATA-3	Interleukin-13	14462(Tax:10090)	16163(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Interleukin-13 gene expression is regulated by GATA-3 in T cells : role of a critical association of a GATA and two GATG motifs .
25757968	0	GATA-3	80,86	T-bet	72,77	GATA-3	T-bet	733631(Tax:9823)	100518804	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of Shenfu injection on the expression of transcription factors T-bet / GATA-3 in pigs with post-resuscitation myocardial_dysfunction -RSB- .
9261181	0	GATA-3	21,27	Th1	66,69	GATA-3	Th1	14462(Tax:10090)	57314(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene .
11067915	0	GATA-3	91,97	Th2	117,120	GATA-3	Th2	14462(Tax:10090)	15111(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|expression expression|amod|END_ENTITY	Cyclic_AMP activates p38 mitogen-activated protein kinase in Th2 cells : phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression .
9125153	0	GATA-3	48,54	aquaporin-2	14,25	GATA-3	aquaporin-2	85471(Tax:10116)	25386(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of aquaporin-2 gene transcription by GATA-3 .
21761347	0	GATA-3	73,79	aurora_kinase-A	17,32	GATA-3	aurora kinase-A	2625	6790	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Estrogen-induced aurora_kinase-A -LRB- AURKA -RRB- gene expression is activated by GATA-3 in estrogen_receptor-positive breast_cancer cells .
25651379	0	GATA-3	108,114	caspase-14	115,125	GATA-3	caspase-14	2625	23581	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3 / caspase-14 pathway in A431 cells .
18338249	0	GATA-3	21,27	dopamine_beta-hydroxylase	70,95	GATA-3	dopamine beta-hydroxylase	2625	1621	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Transcription factor GATA-3 regulates the transcriptional activity of dopamine_beta-hydroxylase by interacting with Sp1 and AP4 .
10096242	0	GATA-3	0,6	estrogen_receptor	40,57	GATA-3	estrogen receptor	2625	2099	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	GATA-3 is expressed in association with estrogen_receptor in breast_cancer .
17616709	0	GATA-3	36,42	estrogen_receptor_alpha	46,69	GATA-3	estrogen receptor alpha	2625	2099	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Positive cross-regulatory loop ties GATA-3 to estrogen_receptor_alpha expression in breast_cancer .
9801155	0	GATA-3	0,6	gp91phox	17,25	GATA-3	gp91phox	2625	1536	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	GATA-3 represses gp91phox gene expression in eosinophil-committed HL-60-C15 cells .
23163652	0	GATA-3	0,6	loricrin	42,50	GATA-3	loricrin	2625	4014	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	GATA-3 regulates differentiation-specific loricrin gene expression in keratinocytes .
11067915	0	GATA-3	91,97	p38	21,24	GATA-3	p38	14462(Tax:10090)	26416(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY kinase|dep|phosphorylation kinase|amod|END_ENTITY	Cyclic_AMP activates p38 mitogen-activated protein kinase in Th2 cells : phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression .
17277157	0	GATA-3	73,79	p38	36,39	GATA-3	p38	2625	1432	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3 .
11279028	0	GATA-4	26,32	B-type_natriuretic_peptide	56,82	GATA-4	B-type natriuretic peptide	2626	4879	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Cooperative activation by GATA-4 and YY1 of the cardiac B-type_natriuretic_peptide promoter .
18653721	0	GATA-4	0,6	Bcl-2	17,22	GATA-4	Bcl-2	2626	596	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	GATA-4 regulates Bcl-2 expression in ovarian_granulosa_cell_tumors .
15220332	0	GATA-4	20,26	FOG-2	0,5	GATA-4	FOG-2	2626	23414	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes .
22674427	0	GATA-4	105,111	GATA-4	49,55	GATA-4	GATA-4	54254(Tax:10116)	54254(Tax:10116)	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|compound|END_ENTITY	Erythropoietin-activated ERK/MAP kinase enhances GATA-4 acetylation via phosphorylation of serine 261 of GATA-4 .
22674427	0	GATA-4	49,55	GATA-4	105,111	GATA-4	GATA-4	54254(Tax:10116)	54254(Tax:10116)	Gene	Gene	acetylation|compound|START_ENTITY acetylation|nmod|END_ENTITY	Erythropoietin-activated ERK/MAP kinase enhances GATA-4 acetylation via phosphorylation of serine 261 of GATA-4 .
21702924	0	GATA-4	42,48	GATA_binding_protein_4	18,40	GATA-4	GATA binding protein 4	54254(Tax:10116)	54254(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Molecular role of GATA_binding_protein_4 -LRB- GATA-4 -RRB- in hyperglycemia-induced reduction of cardiac contractility .
9209438	0	GATA-4	35,41	IL-5	74,78	GATA-4	IL-5	2626	3567	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|promoter promoter|compound|END_ENTITY	Of the GATA-binding proteins , only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins .
26386639	0	GATA-4	73,79	SF-1	80,84	GATA-4	SF-1	14463(Tax:10090)	22668(Tax:10090)	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4 / SF-1 transcription factors .
12067842	0	GATA-4	58,64	brain_natriuretic_peptide	24,49	GATA-4	brain natriuretic peptide	2626	4879	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the human brain_natriuretic_peptide gene by GATA-4 .
10579051	0	GATA-4	14,20	cardiac_calsequestrin	64,85	GATA-4	cardiac calsequestrin	14463(Tax:10090)	12373(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of GATA-4 and AP-1 in transgenic_mice overexpressing cardiac_calsequestrin .
9065755	0	GATA-4	74,80	cardiac_troponin_I	22,40	GATA-4	cardiac troponin I	54254(Tax:10116)	29248(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the rat cardiac_troponin_I gene by the transcription factor GATA-4 .
23409073	0	GATA-4	114,120	cingulin	24,32	GATA-4	cingulin	486079(Tax:9615)	483198(Tax:9615)	Gene	Gene	modulate|nmod|START_ENTITY modulate|nsubj|END_ENTITY	The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4 .
11159521	0	GATA-4	60,66	coagulation_factor_X	20,40	GATA-4	coagulation factor X	2626	2159	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of human coagulation_factor_X gene expression by GATA-4 and the Sp family of transcription factors .
20206639	0	GATA-4	25,31	cytochrome_P4502C19	42,61	GATA-4	cytochrome P4502C19	2626	1557	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The transcription factor GATA-4 regulates cytochrome_P4502C19 gene expression .
18343025	0	GATA-4	0,6	glucose-dependent_insulinotropic_polypeptide	19,63	GATA-4	glucose-dependent insulinotropic polypeptide	14463(Tax:10090)	14607(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	GATA-4 upregulates glucose-dependent_insulinotropic_polypeptide expression in cells of pancreatic and intestinal lineage .
15178553	0	GATA-4	66,72	lactase-phlorizin_hydrolase	26,53	GATA-4	lactase-phlorizin hydrolase	14463(Tax:10090)	226413(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	Complex regulation of the lactase-phlorizin_hydrolase promoter by GATA-4 .
14666170	0	GATA-4	116,122	luteinizing_hormone_receptor	61,89	GATA-4	luteinizing hormone receptor	14463(Tax:10090)	16867(Tax:10090)	Gene	Gene	factors|amod|START_ENTITY factors|compound|END_ENTITY	Adrenocortical_tumorigenesis in transgenic_mice : the role of luteinizing_hormone_receptor and transcription factors GATA-4 and GATA-61 .
17337116	0	GATA-4	85,91	luteinizing_hormone_receptor	30,58	GATA-4	luteinizing hormone receptor	14463(Tax:10090)	16867(Tax:10090)	Gene	Gene	factors|amod|START_ENTITY factors|compound|END_ENTITY	Adrenocortical_tumorigenesis , luteinizing_hormone_receptor and transcription factors GATA-4 and GATA-6 .
23558708	0	GATA-4	17,23	miR-200b	0,8	GATA-4	miR-200b	2626	406984	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-200b targets GATA-4 during cell growth and differentiation .
14986113	0	GATA-5	21,27	mucin	53,58	GATA-5	mucin	140628	100508689	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Transcription factor GATA-5 selectively up-regulates mucin gene expression .
22855527	0	GATA-6	0,6	BMP-2	47,52	GATA-6	BMP-2	14465(Tax:10090)	12156(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation .
23275439	0	GATA-6	0,6	CPI-17	26,32	GATA-6	CPI-17	14465(Tax:10090)	68458(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|transcription transcription|compound|END_ENTITY	GATA-6 and NF-kB activate CPI-17 gene transcription and regulate Ca2 + sensitization of smooth muscle contraction .
22100307	0	GATA-6	21,27	PPARa	37,42	GATA-6	PPARa	2627	5465	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Transcription factor GATA-6 recruits PPARa to cooperatively activate Glut4 gene expression .
18768929	0	GATA-6	0,6	aquaporin-5	46,57	GATA-6	aquaporin-5	14465(Tax:10090)	11830(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 .
9593712	0	GATA-6	0,6	p21	15,18	GATA-6	p21	14465(Tax:10090)	12575(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	GATA-6 induces p21 -LRB- Cip1 -RRB- expression and G1 cell cycle arrest .
16557299	0	GATA-6	0,6	semaphorin_3C	17,30	GATA-6	semaphorin 3C	2627	10512	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GATA-6 regulates semaphorin_3C and is required in cardiac neural crest for cardiovascular morphogenesis .
10625644	0	GATA-6	0,6	surfactant_protein_A	34,54	GATA-6	surfactant protein A	14465(Tax:10090)	20387(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	GATA-6 activates transcription of surfactant_protein_A .
9915795	0	GATA-6	0,6	thyroid_transcription_factor-1	34,64	GATA-6	thyroid transcription factor-1	2627	7080	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	GATA-6 activates transcription of thyroid_transcription_factor-1 .
25069192	0	GATA-binding_protein_3	98,120	T-bet	91,96	GATA-binding protein 3	T-bet	14462(Tax:10090)	57765(Tax:10090)	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	-LSB- Effects of needle pricking therapy of Zhuang minority medicine on expression of pulmonary T-bet , GATA-binding_protein_3 genes and thymic_stromal_lymphopoietin protein in the lung of asthma mice -RSB- .
19556247	0	GATA1	15,20	AGGF1	56,61	GATA1	AGGF1	2623	55109	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function .
22871742	0	GATA1	70,75	CDC6	0,4	GATA1	CDC6	2623	990	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	CDC6 expression is regulated by lineage-specific transcription factor GATA1 .
21844373	0	GATA1	127,132	LMO2	79,83	GATA1	LMO2	2623	4005	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 .
19853566	0	GATA1	41,46	LRF	0,3	GATA1	LRF	2623	51341	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis .
11254675	0	GATA1	71,76	Uroporphyrinogen_III_synthase	0,29	GATA1	Uroporphyrinogen III synthase	2623	7390	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Uroporphyrinogen_III_synthase erythroid promoter mutations in adjacent GATA1 and CP2 elements cause congenital_erythropoietic_porphyria .
25624456	0	GATA2	0,5	GATA2	32,37	GATA2	GATA2	2624	2624	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	GATA2 Germline Mutations Impair GATA2 Transcription , Causing Haploinsufficiency : Functional Analysis of the p.Arg396Gln Mutation .
25624456	0	GATA2	32,37	GATA2	0,5	GATA2	GATA2	2624	2624	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	GATA2 Germline Mutations Impair GATA2 Transcription , Causing Haploinsufficiency : Functional Analysis of the p.Arg396Gln Mutation .
25670076	0	GATA2	64,69	IGF2	84,88	GATA2	IGF2	2624	3481	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Taxane Resistance in Prostate_Cancer Mediated by AR-Independent GATA2 Regulation of IGF2 .
22021428	0	GATA2	0,5	PTEN	27,31	GATA2	PTEN	2624	5728	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen_receptor and by androgen-independent suppression of PTEN transcription in breast_cancer .
20838640	0	GATA2	118,123	TSHb	127,131	GATA2	TSHb	2624	7252	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Dissecting the Relation between a nuclear receptor and GATA : binding affinity studies of thyroid hormone receptor and GATA2 on TSHb promoter .
20154722	0	GATA3	48,53	Cyclin_D1	0,9	GATA3	Cyclin D1	2625	595	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cyclin_D1 is a direct transcriptional target of GATA3 in neuroblastoma_tumor cells .
24820417	0	GATA3	13,18	Fbw7	0,4	GATA3	Fbw7	14462(Tax:10090)	50754(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Fbw7 targets GATA3 through cyclin-dependent_kinase_2-dependent proteolysis and contributes to regulation of T-cell development .
24813204	0	GATA3	17,22	IFN-a	0,5	GATA3	IFN-a	2625	3438	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells .
19346497	0	GATA3	29,34	IFN-lambda1	0,11	GATA3	IFN-lambda1	2625	282618	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IFN-lambda1 -LRB- IL-29 -RRB- inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells .
26682056	0	GATA3	20,25	IL-10	66,71	GATA3	IL-10	2625	3586	Gene	Gene	expression|nmod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Lower expression of GATA3 and T-bet correlates with downregulated IL-10 in severe falciparum_malaria .
11135577	0	GATA3	34,39	NF-kappa_B	20,30	GATA3	NF-kappa B	14462(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A critical role for NF-kappa_B in GATA3 expression and TH2 differentiation in allergic_airway_inflammation .
23851505	0	GATA3	0,5	PARP1	22,27	GATA3	PARP1	2625	142	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation .
25479686	0	GATA3	47,52	Progesterone_receptor	0,21	GATA3	Progesterone receptor	2625	5241	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	Progesterone_receptor activation downregulates GATA3 by transcriptional repression and increased_protein_turnover promoting breast_tumor growth .
19411068	0	GATA3	51,56	p18	14,17	GATA3	p18	2625	1031	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CDK inhibitor p18 -LRB- INK4c -RRB- is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis .
25501827	0	GATA4	43,48	Caspase-1	0,9	GATA4	Caspase-1	2626	834	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate .
26893347	0	GATA4	0,5	Fgf16	16,21	GATA4	Fgf16	14463(Tax:10090)	80903(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GATA4 regulates Fgf16 to promote heart repair after injury .
21839733	0	GATA4	21,26	GATA5	0,5	GATA4	GATA5	2626	140628	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GATA5 interacts with GATA4 and GATA6 in outflow tract development .
26490736	0	GATA4	48,53	GATA_binding_protein_4	24,46	GATA4	GATA binding protein 4	2626	2626	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Hypermethylation of the GATA_binding_protein_4 -LRB- GATA4 -RRB- promoter in Chinese pediatric acute myeloid_leukemia .
11382772	0	GATA4	41,46	Glycogen_synthase_kinase_3beta	0,30	GATA4	Glycogen synthase kinase 3beta	2626	2932	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase_3beta regulates GATA4 in cardiac myocytes .
24866383	0	GATA4	14,19	NEXN	0,4	GATA4	NEXN	14463(Tax:10090)	68810(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	NEXN inhibits GATA4 and leads to atrial_septal_defects in mice and humans .
11228750	0	GATA4	43,48	angiotensin_II	14,28	GATA4	angiotensin II	2626	183	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Modulation of angiotensin_II signaling for GATA4 activation by homocysteine .
22558183	0	GATA4	53,58	angiotensin_II	122,136	GATA4	angiotensin II	14463(Tax:10090)	11606(Tax:10090)	Gene	Gene	hypertrophic|nummod|START_ENTITY hypertrophic|acl|signaling signaling|nmod|receptor receptor|compound|END_ENTITY	Promyelocytic_leukemia_zinc_finger_protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin_II receptor 2 .
26973342	0	GATA4	0,5	bone_sialoprotein	27,44	GATA4	bone sialoprotein	2626	3381	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	GATA4 negatively regulates bone_sialoprotein expression in osteoblasts .
17081402	0	GATA4	59,64	cardiotrophin-1	11,26	GATA4	cardiotrophin-1	54254(Tax:10116)	29201(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	-LSB- Effect of cardiotrophin-1 on cardiac transcription factor GATA4 expression in rat cardiomyocytes -RSB- .
11156886	0	GATA4	28,33	endothelin-1	55,67	GATA4	endothelin-1	54254(Tax:10116)	24323(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Pressure overload increases GATA4 binding activity via endothelin-1 .
22431517	0	GATA4	107,112	ms1/STARS	22,31	GATA4	ms1/STARS	2626	4397;137735	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Cardiac expression of ms1/STARS , a novel gene involved in cardiac development and disease , is regulated by GATA4 .
21839733	0	GATA5	0,5	GATA4	21,26	GATA5	GATA4	140628	2626	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GATA5 interacts with GATA4 and GATA6 in outflow tract development .
22625849	0	GATA5	40,45	Upstream_stimulatory_factor_1	0,29	GATA5	Upstream stimulatory factor 1	14464(Tax:10090)	7391	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Upstream_stimulatory_factor_1 activates GATA5 expression through an E-box motif .
22504665	0	GATA6	69,74	BMP4	49,53	GATA6	BMP4	2627	652	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	microRNA-145 in Barrett 's _ oesophagus : regulating BMP4 signalling via GATA6 .
9832509	0	GATA6	0,5	HNF4	16,20	GATA6	HNF4	14465(Tax:10090)	15378(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo .
26387746	0	GATA6	36,41	REG4	0,4	GATA6	REG4	2627	83998	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis .
24415953	0	GATA6	0,5	Shh	32,35	GATA6	Shh	14465(Tax:10090)	20423(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	GATA6 is a crucial regulator of Shh in the limb bud .
16621466	0	GATA6	38,43	Wnt2	0,4	GATA6	Wnt2	14465(Tax:10090)	22413(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Wnt2 is a direct downstream target of GATA6 during early cardiogenesis .
22607194	0	GATA6	0,5	Wnt6	25,29	GATA6	Wnt6	2627	7475	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	GATA6 and FOXA2 regulate Wnt6 expression during extraembryonic endoderm formation .
25068583	0	GATA6	85,90	miR-10a	0,7	GATA6	miR-10a	2627	406902	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-10a regulates proliferation of human cardiomyocyte progenitor cells by targeting GATA6 .
21127043	0	GATA6	0,5	transforming_growth_factor_beta	97,128	GATA6	transforming growth factor beta	2627	7040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming_growth_factor_beta / activin_receptor-like_kinase_5 signaling .
21702924	0	GATA_binding_protein_4	18,40	GATA-4	42,48	GATA binding protein 4	GATA-4	54254(Tax:10116)	54254(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Molecular role of GATA_binding_protein_4 -LRB- GATA-4 -RRB- in hyperglycemia-induced reduction of cardiac contractility .
26490736	0	GATA_binding_protein_4	24,46	GATA4	48,53	GATA binding protein 4	GATA4	2626	2626	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Hypermethylation of the GATA_binding_protein_4 -LRB- GATA4 -RRB- promoter in Chinese pediatric acute myeloid_leukemia .
10856287	0	GATE-16	13,20	Aut7p	101,106	GATE-16	Aut7p	11345	852200(Tax:4932)	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of GATE-16 , membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p .
10747018	0	GATE-16	0,7	NSF	56,59	GATE-16	NSF	282531(Tax:9913)	504457(Tax:9913)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GATE-16 , a membrane transport modulator , interacts with NSF and the Golgi v-SNARE GOS-28 .
21669198	0	GATE-16	38,45	OSBP-related_protein_7	0,22	GATE-16	OSBP-related protein 7	11345	114881	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	OSBP-related_protein_7 interacts with GATE-16 and negatively regulates GS28 protein stability .
24269818	0	GATE16	81,87	ATG8	66,70	GATE16	ATG8	11345	11345	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	The Ca2 + channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy .
22761875	0	GB1	23,26	ERK1/2	71,77	GB1	ERK1/2	54393(Tax:10090)	26417;26413	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation .
15325338	0	GBA	68,71	glucocerebrosidase	48,66	GBA	glucocerebrosidase	2629	2629	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Comparative and genetic analysis of the porcine glucocerebrosidase -LRB- GBA -RRB- gene .
23418352	0	GBF1	20,24	AMPK	0,4	GBF1	AMPK	8729	5563	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	AMPK phosphorylates GBF1 for mitotic Golgi disassembly .
22766018	0	GBF1	31,35	HY1	0,3	GBF1	HY1	829826(Tax:3702)	817208(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HY1 genetically interacts with GBF1 and regulates the activity of the Z-box containing promoters in light signaling pathways in Arabidopsis_thaliana .
22692212	0	GBF1	26,30	HY5	36,39	GBF1	HY5	829826(Tax:3702)	830996(Tax:3702)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis_thaliana .
17429068	0	GBF1	21,25	Rab1b	0,5	GBF1	Rab1b	8729	81876	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association .
12634853	0	GBF1	51,55	p115	31,35	GBF1	p115	8729	8615	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The membrane-tethering protein p115 interacts with GBF1 , an ARF guanine-nucleotide-exchange factor .
9858320	0	GBP	52,55	GBP-2	7,12	GBP	GBP-2	16854(Tax:10090)	14469(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	Murine GBP-2 : a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages .
9635432	0	GBP	0,3	GSK-3	21,26	GBP	GSK-3	398043(Tax:8355)	399097(Tax:8355)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	GBP , an inhibitor of GSK-3 , is implicated in Xenopus development and oncogenesis .
9858320	0	GBP-2	7,12	GBP	52,55	GBP-2	GBP	14469(Tax:10090)	16854(Tax:10090)	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	Murine GBP-2 : a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages .
19358743	0	GC-1	0,4	mRHBDD1	5,12	GC-1	mRHBDD1	14919(Tax:10090)	76867(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic capacity in mouse seminiferous tubules .
21106860	0	GC-C	103,107	uroguanylin	121,132	GC-C	uroguanylin	25711(Tax:10116)	64055(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	The rat kidney contains high levels of prouroguanylin -LRB- the uroguanylin precursor -RRB- but does not express GC-C -LRB- the enteric uroguanylin receptor -RRB- .
21140450	0	GC-binding_factor_2	0,19	dishevelled	35,46	GC-binding factor 2	dishevelled	9208	8215	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GC-binding_factor_2 interacts with dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines .
15735604	0	GCAP1	68,73	GUCA1A	80,86	GCAP1	GUCA1A	2980	2978	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Autosomal_dominant_cone_dystrophy caused by a novel mutation in the GCAP1 gene -LRB- GUCA1A -RRB- .
18541533	0	GCAP1	50,55	guanylyl_cyclase_activating_protein_1	11,48	GCAP1	guanylyl cyclase activating protein 1	2978	2978	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of guanylyl_cyclase_activating_protein_1 -LRB- GCAP1 -RRB- to retinal_guanylyl cyclase -LRB- RetGC1 -RRB- .
21305056	0	GCC	28,31	guanylyl_cyclase_C	8,26	GCC	guanylyl cyclase C	14917(Tax:10090)	14917(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Loss of guanylyl_cyclase_C -LRB- GCC -RRB- signaling leads to dysfunctional intestinal barrier .
21901559	0	GCC	37,40	guanylyl_cyclase_c	17,35	GCC	guanylyl cyclase c	2984	2984	Gene	Gene	expressions|appos|START_ENTITY expressions|compound|END_ENTITY	Peripheral blood guanylyl_cyclase_c -LRB- GCC -RRB- expressions are associated with prognostic parameters and response to therapy in colorectal_cancer patients .
22159419	0	GCC185	16,22	ARL4A	0,5	GCC185	ARL4A	9648	101928788	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	ARL4A acts with GCC185 to modulate Golgi complex organization .
10330157	0	GCD14p	0,6	Gcd10p	57,63	GCD14p	Gcd10p	853317(Tax:4932)	855663(Tax:4932)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	GCD14p , a repressor of GCN4 translation , cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces_cerevisiae .
2038326	0	GCD2	0,4	GCN4	39,43	GCD2	GCN4	852974(Tax:4932)	856709(Tax:4932)	Gene	Gene	START_ENTITY|appos|repressor repressor|nmod|gene gene|compound|END_ENTITY	GCD2 , a translational repressor of the GCN4 gene , has a general function in the initiation of protein synthesis in Saccharomyces_cerevisiae .
2668116	0	GCD2	46,50	GCN4	76,80	GCD2	GCN4	852974(Tax:4932)	856709(Tax:4932)	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	gcd12 mutations are gcn3-dependent alleles of GCD2 , a negative regulator of GCN4 in the general amino_acid control of Saccharomyces_cerevisiae .
2626033	0	GCDFP-15	112,120	GCDFP-15	46,54	GCDFP-15	GCDFP-15	5304	5304	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Antagonism between estrogens and androgens on GCDFP-15 gene expression in ZR-75-1 cells and correlation between GCDFP-15 and estrogen as well as progesterone_receptor expression in human breast_cancer .
25070172	0	GCDFP-15	39,47	Gross_cystic_disease_fluid_protein_15	0,37	GCDFP-15	Gross cystic disease fluid protein 15	5304	5304	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Gross_cystic_disease_fluid_protein_15 -LRB- GCDFP-15 -RRB- expression in breast_cancer subtypes .
12890565	0	GCDFP-15	48,56	PIP	57,60	GCDFP-15	PIP	5304	5304	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|gene gene|compound|END_ENTITY	Expression of the mouse homologue for the human GCDFP-15 / PIP gene during pre - and early post-natal development .
14761115	0	GCF	27,30	IFN-gamma	31,40	GCF	IFN-gamma	6936	3458	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Longitudinal evaluation of GCF IFN-gamma levels and periodontal status in HIV + patients .
22571463	0	GCF2	25,29	RhoA	75,79	GCF2	RhoA	9208	387	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA , regulating membrane protein trafficking , sensitivity to doxorubicin , and resistance to cisplatin .
20491893	0	GCH1	51,55	GTP_cyclohydrolase_I	29,49	GCH1	GTP cyclohydrolase I	2643	2643	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel missense mutation in GTP_cyclohydrolase_I -LRB- GCH1 -RRB- gene causes Dopa-responsive_dystonia in Chinese Han population .
17532760	0	GCIP	6,10	CT847	26,31	GCIP	CT847	23582	884648(Tax:272561)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human GCIP interacts with CT847 , a novel Chlamydia_trachomatis type III secretion substrate , and is degraded in a tissue-culture infection model .
14517946	0	GCK	13,16	Glucokinase	0,11	GCK	Glucokinase	2645	2645	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Glucokinase -LRB- GCK -RRB- mutations in hyper - and hypoglycemia : maturity-onset_diabetes_of_the_young , permanent neonatal diabetes , and hyperinsulinemia of infancy .
1740341	0	GCK	68,71	glucokinase	50,61	GCK	glucokinase	2645	2645	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A polymorphic -LRB- CA -RRB- n repeat element maps the human glucokinase gene -LRB- GCK -RRB- to chromosome 7p .
18571549	0	GCK	87,90	glucokinase	74,85	GCK	glucokinase	2645	2645	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Permanent_neonatal_diabetes_mellitus caused by a novel homozygous -LRB- T168A -RRB- glucokinase -LRB- GCK -RRB- mutation : initial response to oral sulphonylurea therapy .
24728127	0	GCK	50,53	glucokinase	32,43	GCK	glucokinase	2645	2645	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variation in the glucokinase gene -LRB- GCK -RRB- is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure .
25656763	0	GCK	70,73	glucokinase	57,68	GCK	glucokinase	2645	2645	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pitfalls in the diagnosis of frameshift mutations in the glucokinase -LRB- GCK -RRB- gene and the contribution of an additional cloning sequencing tool .
21318467	0	GCKR	32,36	Glucokinase_regulatory_protein	0,30	GCKR	Glucokinase regulatory protein	2646	2646	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Glucokinase_regulatory_protein -LRB- GCKR -RRB- gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women .
22105854	0	GCKR	47,51	glucokinase_regulatory_protein	15,45	GCKR	glucokinase regulatory protein	2646	2646	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variant in the glucokinase_regulatory_protein -LRB- GCKR -RRB- gene is associated with fatty_liver in obese children and adolescents .
19692500	0	GCM1	35,39	CD9	0,3	GCM1	CD9	8521	928	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	CD9 regulates transcription factor GCM1 and ERVWE1 expression through the cAMP/protein kinase A signaling pathway .
23651062	0	GCM1	119,123	glial_cell_missing_1	125,145	GCM1	glial cell missing 1	8521	8521	Gene	Gene	stability|amod|START_ENTITY stability|appos|END_ENTITY	RACK1 -LRB- receptor_for_activated_C-kinase_1 -RRB- interacts with FBW2 -LRB- F-box and WD-repeat domain-containing 2 -RRB- to up-regulate GCM1 -LRB- glial_cell_missing_1 -RRB- stability and placental cell migration and invasion .
20463099	0	GCMB	42,46	glial_cells_missing_homolog_B	11,40	GCMB	glial cells missing homolog B	9247	9247	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A missense glial_cells_missing_homolog_B -LRB- GCMB -RRB- mutation , Asn502His , causes autosomal_dominant_hypoparathyroidism .
15640526	0	GCMa	13,17	FBW2	0,4	GCMa	FBW2	8521	26190	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	FBW2 targets GCMa to the ubiquitin-proteasome degradation system .
11101534	0	GCN1	20,24	GCN2	88,92	GCN1	GCN2	10985	440275	Gene	Gene	domains|nmod|START_ENTITY required|nsubjpass|domains required|nmod|activation activation|nummod|END_ENTITY	Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino_acid-starved cells .
11350982	0	GCN1	14,18	GCN2	72,76	GCN1	GCN2	852680(Tax:4932)	851877(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|activate activate|dobj|END_ENTITY	Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2 .
15722345	0	GCN1	24,28	GCN2	121,125	GCN1	GCN2	852680(Tax:4932)	851877(Tax:4932)	Gene	Gene	binding|nmod|START_ENTITY required|nsubjpass|binding required|nmod|activation activation|nmod|END_ENTITY	Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2 -LCB- alpha -RCB- kinase GCN2 during amino_acid starvation .
15937339	0	GCN1	69,73	GCN2	87,91	GCN1	GCN2	852680(Tax:4932)	27103(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	IMPACT , a protein preferentially expressed in the mouse brain , binds GCN1 and inhibits GCN2 activation .
24333428	0	GCN1	78,82	GCN2	114,118	GCN1	GCN2	10985	440275	Gene	Gene	START_ENTITY|acl|activating activating|dobj|END_ENTITY	Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2 .
8497269	0	GCN1	0,4	GCN2	165,169	GCN1	GCN2	852680(Tax:4932)	851877(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	GCN1 , a translational activator of GCN4 in Saccharomyces_cerevisiae , is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2 .
9234705	0	GCN1	14,18	GCN2	131,135	GCN1	GCN2	852680(Tax:4932)	851877(Tax:4932)	Gene	Gene	Evidence|nmod|START_ENTITY function|nsubj|Evidence function|advcl|elongating elongating|nmod|activation activation|nmod|END_ENTITY	Evidence that GCN1 and GCN20 , translational regulators of GCN4 , function on elongating ribosomes in activation of eIF2alpha kinase GCN2 .
8497269	0	GCN1	0,4	GCN4	35,39	GCN1	GCN4	852680(Tax:4932)	856709(Tax:4932)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	GCN1 , a translational activator of GCN4 in Saccharomyces_cerevisiae , is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2 .
11101534	0	GCN2	88,92	GCN1	20,24	GCN2	GCN1	440275	10985	Gene	Gene	activation|nummod|START_ENTITY required|nmod|activation required|nsubjpass|domains domains|nmod|END_ENTITY	Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino_acid-starved cells .
11350982	0	GCN2	72,76	GCN1	14,18	GCN2	GCN1	851877(Tax:4932)	852680(Tax:4932)	Gene	Gene	activate|dobj|START_ENTITY binds|xcomp|activate binds|nsubj|END_ENTITY	Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2 .
15722345	0	GCN2	121,125	GCN1	24,28	GCN2	GCN1	851877(Tax:4932)	852680(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|binding binding|nmod|END_ENTITY	Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2 -LCB- alpha -RCB- kinase GCN2 during amino_acid starvation .
15937339	0	GCN2	87,91	GCN1	69,73	GCN2	GCN1	27103(Tax:10090)	852680(Tax:4932)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	IMPACT , a protein preferentially expressed in the mouse brain , binds GCN1 and inhibits GCN2 activation .
24333428	0	GCN2	114,118	GCN1	78,82	GCN2	GCN1	440275	10985	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|acl|activating	Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2 .
8497269	0	GCN2	165,169	GCN1	0,4	GCN2	GCN1	851877(Tax:4932)	852680(Tax:4932)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	GCN1 , a translational activator of GCN4 in Saccharomyces_cerevisiae , is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2 .
9234705	0	GCN2	131,135	GCN1	14,18	GCN2	GCN1	851877(Tax:4932)	852680(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY elongating|nmod|activation function|advcl|elongating function|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence that GCN1 and GCN20 , translational regulators of GCN4 , function on elongating ribosomes in activation of eIF2alpha kinase GCN2 .
21239490	0	GCN2	79,83	Gcn1	0,4	GCN2	Gcn1	440275	10985	Gene	Gene	activation|nmod|START_ENTITY implications|nmod|activation END_ENTITY|dep|implications	Gcn1 and actin binding to Yih1 : implications for activation of the eIF2 kinase GCN2 .
15355306	0	GCN2	0,4	eIF2alpha	24,33	GCN2	eIF2alpha	440275	83939	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation .
25329545	0	GCN2	45,49	p58	0,3	GCN2	p58	440275	984	Gene	Gene	Inhibitor|nmod|START_ENTITY Inhibitor|nsubj|END_ENTITY	p58 -LRB- IPK -RRB- is an Inhibitor of the eIF2a Kinase GCN2 and its Localisation and Expression Underpin Protein Synthesis and ER Processing Capacity .
3062370	0	GCN3	22,26	GCN4	57,61	GCN3	GCN4	853896(Tax:4932)	856709(Tax:4932)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Molecular analysis of GCN3 , a translational activator of GCN4 : evidence for posttranslational control of GCN3 regulatory function .
2038326	0	GCN4	39,43	GCD2	0,4	GCN4	GCD2	856709(Tax:4932)	852974(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY repressor|nmod|gene END_ENTITY|appos|repressor	GCD2 , a translational repressor of the GCN4 gene , has a general function in the initiation of protein synthesis in Saccharomyces_cerevisiae .
2668116	0	GCN4	76,80	GCD2	46,50	GCN4	GCD2	856709(Tax:4932)	852974(Tax:4932)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	gcd12 mutations are gcn3-dependent alleles of GCD2 , a negative regulator of GCN4 in the general amino_acid control of Saccharomyces_cerevisiae .
8497269	0	GCN4	35,39	GCN1	0,4	GCN4	GCN1	856709(Tax:4932)	852680(Tax:4932)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	GCN1 , a translational activator of GCN4 in Saccharomyces_cerevisiae , is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2 .
3062370	0	GCN4	57,61	GCN3	22,26	GCN4	GCN3	856709(Tax:4932)	853896(Tax:4932)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Molecular analysis of GCN3 , a translational activator of GCN4 : evidence for posttranslational control of GCN3 regulatory function .
9154821	0	GCN5	74,78	ADA1	0,4	GCN5	ADA1	2648	117143	Gene	Gene	effects|nmod|START_ENTITY has|dobj|effects has|nsubj|END_ENTITY	ADA1 , a novel component of the ADA/GCN5 complex , has broader effects than GCN5 , ADA2 , or ADA3 .
17760996	0	GCN5	37,41	ISWI	29,33	GCN5	ISWI	39431(Tax:7227)	36390(Tax:7227)	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|nmod|END_ENTITY	Site-specific acetylation of ISWI by GCN5 .
23142079	0	GCN5	54,58	Sirt6	16,21	GCN5	Sirt6	14534(Tax:10090)	50721(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis .
8620450	0	GCNA1	58,63	germ_cell_nuclear_antigen	31,56	GCNA1	germ cell nuclear antigen	107425(Tax:10090)	107425(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of a specific mouse germ_cell_nuclear_antigen -LRB- GCNA1 -RRB- by early embryonic testicular_teratoma cells in 129/Sv-Sl / + mice .
18809212	0	GCP-2	59,64	CXCL6	65,70	GCP-2	CXCL6	6372	6372	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Constitutive expression of the antibacterial CXC chemokine GCP-2 / CXCL6 by epithelial cells of the male reproductive tract .
12533683	0	GCP-2	18,23	CXCL8	170,175	GCP-2	CXCL8	6372	3576	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	The CXC chemokine GCP-2 / CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma : comparison with interleukin-8 / CXCL8 .
12591113	0	GCP-2	53,58	GRO-alpha	61,70	GCP-2	GRO-alpha	6372	2919	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Pharmacological modulation of interleukin-17-induced GCP-2 - , GRO-alpha - and interleukin-8 release in human bronchial epithelial cells .
19682932	0	GCP-2	56,61	granulocyte_chemotactic_protein-2	21,54	GCP-2	granulocyte chemotactic protein-2	281735(Tax:9913)	281735(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of bovine granulocyte_chemotactic_protein-2 -LRB- GCP-2 -RRB- in neutrophils and a mammary epithelial cell line -LRB- MAC-T -RRB- in response to various bacterial cell wall components .
22302995	0	GCP6	0,4	Plk4	23,27	GCP6	Plk4	85378	10733	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	GCP6 is a substrate of Plk4 and required for centriole duplication .
12204797	0	GCPII	46,51	glutamate_carboxypeptidase_II	15,44	GCPII	glutamate carboxypeptidase II	2346	2346	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Influence of a glutamate_carboxypeptidase_II -LRB- GCPII -RRB- polymorphism -LRB- 1561C -- > T -RRB- on plasma homocysteine , folate and vitamin_B -LRB- 12 -RRB- levels and its relationship to cardiovascular_disease risk .
22304706	0	GCPII	54,59	glutamate_carboxypeptidase_II	23,52	GCPII	glutamate carboxypeptidase II	2346	2346	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Tissue distribution of glutamate_carboxypeptidase_II -LRB- GCPII -RRB- with a focus on the central and peripheral nervous system .
23169655	0	GCPII	45,50	glutamate_carboxypeptidase_II	14,43	GCPII	glutamate carboxypeptidase II	2346	2346	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of glutamate_carboxypeptidase_II -LRB- GCPII -RRB- activity as a treatment for cognitive_impairment in multiple_sclerosis .
12562397	0	GCR	58,61	glucocorticoid_receptor	33,56	GCR	glucocorticoid receptor	2908	2908	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Flow cytometric determination of glucocorticoid_receptor -LRB- GCR -RRB- expression in lymphocyte subpopulations : lower quantity of GCR in patients with post-traumatic_stress_disorder -LRB- PTSD -RRB- .
17322342	0	GCR1	4,8	GPA1	10,14	GCR1	GPA1	841247(Tax:3702)	817170(Tax:3702)	Gene	Gene	chain|compound|START_ENTITY chain|appos|END_ENTITY	The GCR1 , GPA1 , PRN1 , NF-Y signal chain mediates both blue light and abscisic_acid responses in Arabidopsis .
21538359	0	GCS	43,46	MDR1	0,4	GCS	MDR1	7357	5243	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	MDR1 -LRB- multidrug_resistence_1 -RRB- can regulate GCS -LRB- glucosylceramide_synthase -RRB- in breast_cancer cells .
16959503	0	GCS	59,62	glucosylceramide_synthase	32,57	GCS	glucosylceramide synthase	7357	7357	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	RNAi-mediated inhibition of the glucosylceramide_synthase -LRB- GCS -RRB- gene : A preliminary study towards a therapeutic strategy for Gaucher_disease and other glycosphingolipid storage diseases .
18560890	0	GCS	51,54	glucosylceramide_synthase	24,49	GCS	glucosylceramide synthase	7357	7357	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic relevance of glucosylceramide_synthase -LRB- GCS -RRB- expression in breast_cancer .
25795699	0	GCSF	210,214	granulocyte_colony-stimulating_factor	171,208	GCSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	REpeated AutoLogous Infusions of STem cells In Cirrhosis -LRB- REALISTIC -RRB- : a multicentre , phase II , open-label , randomised controlled trial of repeated autologous infusions of granulocyte_colony-stimulating_factor -LRB- GCSF -RRB- mobilised CD133 + bone marrow stem cells in patients with cirrhosis .
16478993	0	GCUNC-45	0,8	hsp90	60,65	GCUNC-45	hsp90	55898	3320	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	GCUNC-45 is a novel regulator for the progesterone_receptor / hsp90 chaperoning pathway .
7608118	0	GD3	35,38	Interleukin_4	0,13	GD3	Interleukin 4	117189	3565	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin_4 enhances ganglioside GD3 expression on the human fibroblast cell line WI-38 .
16040804	0	GD3	12,15	p130Cas	58,65	GD3	p130Cas	117189	9564	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant_melanoma cells .
27068854	0	GD3	167,170	p130Cas	104,111	GD3	p130Cas	117189	9564	Gene	Gene	expression|nmod|START_ENTITY activated|nmod|expression END_ENTITY|acl|activated	A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3 .
2302211	0	GD3_synthase	31,43	GM3_synthase	72,84	GD3 synthase	GM3 synthase	25280(Tax:10116)	83505(Tax:10116)	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification to homogeneity of GD3_synthase and partial purification of GM3_synthase from rat brain .
11098147	0	GD3_synthase	65,77	ST8Sia_I	84,92	GD3 synthase	ST8Sia I	20449(Tax:10090)	20449(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and transcriptional regulation of the mouse GD3_synthase gene -LRB- ST8Sia_I -RRB- : comparison of genomic organization of the mouse sialyltransferase genes .
10409709	0	GDA1	21,25	YND1	0,4	GDA1	YND1	856669(Tax:4932)	856722(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	YND1 , a homologue of GDA1 , encodes membrane-bound apyrase required for Golgi N - and O-glycosylation in Saccharomyces_cerevisiae .
18021315	0	GDAP1	19,24	Charcot-Marie-Tooth_type_4A_disease	67,102	GDAP1	Charcot-Marie-Tooth type 4A disease	54332	54332	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cell expression of GDAP1 in the nervous system and pathogenesis of Charcot-Marie-Tooth_type_4A_disease .
12566285	0	GDAP1	75,80	ganglioside-induced_differentiation-associated_protein-1	17,73	GDAP1	ganglioside-induced differentiation-associated protein-1	54332	54332	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the ganglioside-induced_differentiation-associated_protein-1 -LRB- GDAP1 -RRB- gene in intermediate type autosomal recessive Charcot-Marie-Tooth_neuropathy .
24019467	0	GDF-11	14,20	GASP-1	47,53	GDF-11	GASP-1	14561(Tax:10090)	278507(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2 .
25590623	0	GDF-15	34,40	Growth_Differentiation_Factor_15	0,32	GDF-15	Growth Differentiation Factor 15	9518	9518	Gene	Gene	Levels|appos|START_ENTITY Levels|amod|END_ENTITY	Growth_Differentiation_Factor_15 -LRB- GDF-15 -RRB- Plasma Levels Increase during Bleomycin - and Cisplatin-Based Treatment of Testicular_Cancer Patients and Relate to Endothelial Damage .
25171167	0	GDF-15	34,40	Growth_differentiation_factor-15	0,32	GDF-15	Growth differentiation factor-15	9518	9518	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Growth_differentiation_factor-15 -LRB- GDF-15 -RRB- levels are associated with cardiac and renal_injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass .
11579380	5	GDF-15	997,1003	MIC-1	1004,1009	GDF-15	MIC-1	29455(Tax:10116)	9518	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Unilateral cryogenic cortical lesioning induced a significant increase of GDF-15 / MIC-1 mRNA expression and ir at the lesion site and expression in presumed neurons within the dorsal thalamic area .
24384540	0	GDF-15	31,37	cancer-related_anemia	41,62	GDF-15	cancer-related anemia	9518	10903	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hepcidin through GDF-15 in cancer-related_anemia .
23731455	0	GDF-15	53,59	growth_differentiation_factor-15	19,51	GDF-15	growth differentiation factor-15	9518	9518	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum hepcidin and growth_differentiation_factor-15 -LRB- GDF-15 -RRB- levels in polycythemia vera and essential_thrombocythemia .
18852073	0	GDF-8	11,16	Myostatin	0,9	GDF-8	Myostatin	17700(Tax:10090)	17700(Tax:10090)	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Myostatin -LRB- GDF-8 -RRB- deficiency increases fracture callus size , Sox-5 expression , and callus bone volume .
22205678	0	GDF-8	33,38	myostatin	22,31	GDF-8	myostatin	17700(Tax:10090)	17700(Tax:10090)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of myostatin -LRB- GDF-8 -RRB- following musculoskeletal_injury and the effects of exogenous myostatin on muscle and bone healing .
10612437	0	GDF-9	49,54	growth_differentiation_factor-9	16,47	GDF-9	growth differentiation factor-9	59304(Tax:10116)	59304(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of growth_differentiation_factor-9 -LRB- GDF-9 -RRB- mRNA and protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B .
23849650	0	GDF-9	47,52	growth_differentiation_factor_9	14,45	GDF-9	growth differentiation factor 9	100313495(Tax:9615)	100313495(Tax:9615)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of growth_differentiation_factor_9 -LRB- GDF-9 -RRB- during in vitro maturation in canine oocytes .
26733738	0	GDF11	48,53	growth_differentiation_factor_11	14,46	GDF11	growth differentiation factor 11	606826(Tax:9615)	606826(Tax:9615)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Evaluation of growth_differentiation_factor_11 -LRB- GDF11 -RRB- levels in dogs with chronic mitral_valve_insufficiency .
21535154	0	GDF15	16,21	IL6	23,26	GDF15	IL6	9518	3569	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Erythropoietin , GDF15 , IL6 , hepcidin and testosterone levels in a large cohort of elderly individuals with anaemia of known and unknown cause .
23261467	0	GDF15	41,46	MG132	21,26	GDF15	MG132	9518	875581(Tax:243273)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Proteasome inhibitor MG132 induces NAG-1 / GDF15 expression through the p38 MAPK pathway in glioblastoma cells .
21205743	0	GDF15	18,23	NAG-1	12,17	GDF15	NAG-1	23886(Tax:10090)	23886(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of NAG-1 / GDF15 in the inhibition of intestinal_polyps in APC/Min mice by sulindac .
23261467	0	GDF15	41,46	NAG-1	35,40	GDF15	NAG-1	9518	9518	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Proteasome inhibitor MG132 induces NAG-1 / GDF15 expression through the p38 MAPK pathway in glioblastoma cells .
18801729	0	GDF15	58,63	Nonsteroidal_anti-inflammatory_drug-activated_gene	0,50	GDF15	Nonsteroidal anti-inflammatory drug-activated gene	9518	9518	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nonsteroidal_anti-inflammatory_drug-activated_gene -LRB- NAG-1 / GDF15 -RRB- expression is increased by the histone deacetylase inhibitor trichostatin_A .
26004619	0	GDF15	8,13	growth_and_differentiation_factor_15	15,51	GDF15	growth and differentiation factor 15	9518	9518	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of GDF15 -LRB- growth_and_differentiation_factor_15 -RRB- in pulmonary_oxygen_toxicity .
16339188	0	GDF3	0,4	BMP	8,11	GDF3	BMP	9573	649	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	GDF3 , a BMP inhibitor , regulates cell fate in stem cells and early embryos .
18823971	0	GDF3	0,4	BMP	10,13	GDF3	BMP	9573	649	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses .
16721050	0	GDF3	0,4	TGF-beta	26,34	GDF3	TGF-beta	9573	7040	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	GDF3 at the crossroads of TGF-beta signaling .
23423687	0	GDF5	49,53	growth_differentiation_factor_5	16,47	GDF5	growth differentiation factor 5	8200	8200	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rs143383 in the growth_differentiation_factor_5 -LRB- GDF5 -RRB- gene significantly associated with osteoarthritis -LRB- OA -RRB- - a comprehensive meta-analysis .
10610713	0	GDF8	52,56	myostatin	41,50	GDF8	myostatin	2660	2660	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Frequent sequence variation in the human myostatin -LRB- GDF8 -RRB- gene as a marker for analysis of muscle-related phenotypes .
18462481	0	GDF8	54,58	myostatin	43,52	GDF8	myostatin	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two single nucleotide polymorphisms in the myostatin -LRB- GDF8 -RRB- gene have significant association with muscle_depth of commercial Charollais sheep .
20528846	0	GDF9	63,67	Growth_and_Differentiation_Factor_9	26,61	GDF9	Growth and Differentiation Factor 9	100217402(Tax:9940)	100217402(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new polymorphism in the Growth_and_Differentiation_Factor_9 -LRB- GDF9 -RRB- gene is associated with increased ovulation rate and prolificacy in homozygous sheep .
21632818	0	GDF9	181,185	Growth_differentiating_factor_9	0,31	GDF9	Growth differentiating factor 9	2661	2661	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Growth_differentiating_factor_9 -LRB- GDF9 -RRB- and bone_morphogenetic_protein_15 both activate development of human primordial follicles in vitro , with seemingly more beneficial effects of GDF9 .
23266806	0	GDF9B	56,61	growth_differentiation_factor_9B	22,54	GDF9B	growth differentiation factor 9B	100141303(Tax:9940)	100141303(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism study of growth_differentiation_factor_9B -LRB- GDF9B -RRB- gene and its association with reproductive traits in sheep .
21936909	0	GDF_5	69,74	growth_differentiation_factor_5	36,67	GDF 5	growth differentiation factor 5	8200	8200	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	A genetic association study between growth_differentiation_factor_5 -LRB- GDF_5 -RRB- polymorphism and knee osteoarthritis in Thai population .
11903050	0	GDH	80,83	glutamate_dehydrogenase	55,78	GDH	glutamate dehydrogenase	2746	2746	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression , purification and characterization of human glutamate_dehydrogenase -LRB- GDH -RRB- allosteric regulatory mutations .
21333382	0	GDH	54,57	glutamate_dehydrogenase	29,52	GDH	glutamate dehydrogenase	2746	2746	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Organ-specific expression of glutamate_dehydrogenase -LRB- GDH -RRB- subunits in yellow lupine .
9520268	0	GDH	46,49	glutamate_dehydrogenase	21,44	GDH	glutamate dehydrogenase	3234478(Tax:69014)	3234478(Tax:69014)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Sequence analysis of glutamate_dehydrogenase -LRB- GDH -RRB- from the hyperthermophilic archaeon Pyrococcus_sp .
12054566	0	GDH1	0,4	GLN3	32,36	GDH1	GLN3	854557(Tax:4932)	856763(Tax:4932)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	GDH1 expression is regulated by GLN3 , GCN4 , and HAP4 under respiratory growth .
8375508	0	GDI	25,28	Sec4	15,19	GDI	Sec4	34264(Tax:7227)	850543(Tax:4932)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Interaction of Sec4 with GDI proteins from bovine brain , Drosophila_melanogaster and Saccharomyces_cerevisiae .
19570034	0	GDI-1	0,5	Rab10	32,37	GDI-1	Rab10	2664	10890	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation .
10751420	0	GDI1	61,65	PRA1	0,4	GDI1	PRA1	2664	10567	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1 .
23032401	0	GDNF	31,35	Adenosine_A2a_receptor	0,22	GDNF	Adenosine A2a receptor	25453(Tax:10116)	25369(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Adenosine_A2a_receptor induces GDNF expression by the Stat3 signal in vitro .
9883723	0	GDNF	31,35	Artemin	0,7	GDNF	Artemin	2668	9048	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Artemin , a novel member of the GDNF ligand family , supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex .
20888805	0	GDNF	24,28	CD34	70,74	GDNF	CD34	2668	947	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Intravenous infusion of GDNF gene-modified human umbilical cord blood CD34 + cells protects against cerebral_ischemic_injury in spontaneously hypertensive rats .
15207709	0	GDNF	23,27	CRMP-2	13,19	GDNF	CRMP-2	2668	1808	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region .
8674117	0	GDNF	108,112	GDNFR-alpha	74,85	GDNF	GDNFR-alpha	25453(Tax:10116)	25454(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha , a novel receptor for GDNF .
18822276	0	GDNF	95,99	GFR_alpha1	110,120	GDNF	GFR alpha1	14573(Tax:10090)	14585(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor , GFR_alpha1 , gene .
9647690	0	GDNF	18,22	GFRalpha-4	0,10	GDNF	GFRalpha-4	395569(Tax:9031)	395839(Tax:9031)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	GFRalpha-4 , a new GDNF family receptor .
16163265	0	GDNF	5,9	GLAST	120,125	GDNF	GLAST	14573(Tax:10090)	20512(Tax:10090)	Gene	Gene	exert|nsubj|START_ENTITY exert|nmod|END_ENTITY	Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST ?
26375121	0	GDNF	57,61	GLIAL-DERIVED_NEUROTROPHIC_FACTOR	22,55	GDNF	GLIAL-DERIVED NEUROTROPHIC FACTOR	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	PROTEIN|appos|START_ENTITY PROTEIN|compound|END_ENTITY	SCK-2 : ASSOCIATION OF GLIAL-DERIVED_NEUROTROPHIC_FACTOR -LRB- GDNF -RRB- PROTEIN EXPRESSION WITH NEURONAL DEATH IN POST-RESUSCITATION PERIOD .
10550003	0	GDNF	53,57	Glial-Derived_Neurotrophic_Factor	18,51	GDNF	Glial-Derived Neurotrophic Factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Ethanol decreases Glial-Derived_Neurotrophic_Factor -LRB- GDNF -RRB- protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum .
7854063	0	GDNF	45,49	Glial_cell-line_derived_neurotrophic_factor	0,43	GDNF	Glial cell-line derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Glial_cell-line_derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA upregulation in striatum and cortical areas after pilocarpine-induced status_epilepticus in rats .
11600185	0	GDNF	45,49	Glial_cell_line-derived_neurotrophic_factor	0,43	GDNF	Glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene and schizophrenia : polymorphism screening and association analysis .
9013392	0	GDNF	45,49	Glial_cell_line-derived_neurotrophic_factor	0,43	GDNF	Glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene expression in the human brain : a post mortem in situ hybridization study with special reference to Parkinson 's _ disease .
18611290	0	GDNF	53,57	Histone_deacetylase	0,19	GDNF	Histone deacetylase	2668	9734	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	Histone_deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons .
17027275	0	GDNF	27,31	Interleukin-1beta	0,17	GDNF	Interleukin-1beta	2668	3553	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Interleukin-1beta mediates GDNF up-regulation upon dopaminergic injury in ventral midbrain cell cultures .
18524405	0	GDNF	38,42	NCAM	15,19	GDNF	NCAM	2668	4684	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Involvement of NCAM in the effects of GDNF on the neurite outgrowth in the dopamine neurons .
20955573	0	GDNF	0,4	NCAM	100,104	GDNF	NCAM	14573(Tax:10090)	17967(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway .
14686749	0	GDNF	45,49	NGF	40,43	GDNF	NGF	2668	4803	Gene	Gene	IL-6|appos|START_ENTITY IL-6|compound|END_ENTITY	Pain-related differential expression of NGF , GDNF , IL-6 , and their receptors in human vasculitic_neuropathies .
20153340	0	GDNF	68,72	NTN	89,92	GDNF	NTN	25453(Tax:10116)	84423(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Pharmacokinetics and bioactivity of glial cell line-derived factor -LRB- GDNF -RRB- and neurturin -LRB- NTN -RRB- infused into the rat brain .
12372284	0	GDNF	0,4	PEA3	18,22	GDNF	PEA3	2668	2118	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools .
10023033	0	GDNF	14,18	RET	29,32	GDNF	RET	2668	5979	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|appos|END_ENTITY	Expression of GDNF receptor -LRB- RET and GDNFR-alpha -RRB- mRNAs in the spinal cord of patients with amyotrophic_lateral_sclerosis .
9467954	0	GDNF	36,40	Ret	18,21	GDNF	Ret	2668	5979	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Calcium-dependent Ret activation by GDNF and neurturin .
17720696	0	GDNF	50,54	SULF1	0,5	GDNF	SULF1	14573(Tax:10090)	240725(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation .
17141511	0	GDNF	0,4	TGF-beta	64,72	GDNF	TGF-beta	2668	7040	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action .
17069759	0	GDNF	22,26	follitropin_receptor	70,90	GDNF	follitropin receptor	14573(Tax:10090)	14309(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Age-dependent bimodal GDNF regulation during ovarian_tumorigenesis in follitropin_receptor mutant mice .
8854895	0	GDNF	74,78	glial-cell-line-derived_neurotrophic_factor	29,72	GDNF	glial-cell-line-derived neurotrophic factor	2668	2668	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression and regulation of glial-cell-line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA in human astrocytes in vitro .
20625988	0	GDNF	68,72	glial_cell-derived_neurotrophic_factor	28,66	GDNF	glial cell-derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of Panax_ginseng on glial_cell-derived_neurotrophic_factor -LRB- GDNF -RRB- expression and spermatogenesis in rats .
8808409	0	GDNF	69,73	glial_cell-line_derived_neurotrophic_factor	24,67	GDNF	glial cell-line derived neurotrophic factor	14573(Tax:10090)	14573(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Embryonic expression of glial_cell-line_derived_neurotrophic_factor -LRB- GDNF -RRB- suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions .
10426588	0	GDNF	100,104	glial_cell_line-derived_neurotrophic_factor	55,98	GDNF	glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Infrequent detectable somatic mutations of the RET and glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- genes in human pituitary_adenomas .
10637445	0	GDNF	69,73	glial_cell_line-derived_neurotrophic_factor	24,67	GDNF	glial cell line-derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Differential effects of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- in the striatum and substantia nigra of the aged Parkinsonian rat .
11600317	0	GDNF	59,63	glial_cell_line-derived_neurotrophic_factor	14,57	GDNF	glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- in the developing human fetal brain .
11746778	0	GDNF	72,76	glial_cell_line-derived_neurotrophic_factor	27,70	GDNF	glial cell line-derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats .
15003293	0	GDNF	69,73	glial_cell_line-derived_neurotrophic_factor	24,67	GDNF	glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	3 ' UTR -LRB- AGG -RRB- n repeat of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene polymorphism in schizophrenia .
16191208	0	GDNF	77,81	glial_cell_line-derived_neurotrophic_factor	32,75	GDNF	glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Decreased levels of whole blood glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- in remitted patients with mood_disorders .
17331482	0	GDNF	119,123	glial_cell_line-derived_neurotrophic_factor	74,117	GDNF	glial cell line-derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Administration of amitriptyline attenuates noise-induced hearing_loss via glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- induction .
17897812	0	GDNF	73,77	glial_cell_line-derived_neurotrophic_factor	28,71	GDNF	glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis of the glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene in schizophrenia .
18363829	0	GDNF	70,74	glial_cell_line-derived_neurotrophic_factor	25,68	GDNF	glial cell line-derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Serotonin -LRB- 5-HT -RRB- induces glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA expression via the transactivation of fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- in rat C6 glioma cells .
7781171	0	GDNF	74,78	glial_cell_line-derived_neurotrophic_factor	29,72	GDNF	glial cell line-derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Ontogeny and distribution of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA in rat .
9081633	0	GDNF	61,65	glial_cell_line-derived_neurotrophic_factor	16,59	GDNF	glial cell line-derived neurotrophic factor	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA in embryonic rat by in situ hybridization .
9331921	0	GDNF	59,63	glial_cell_line-derived_neurotrophic_factor	14,57	GDNF	glial cell line-derived neurotrophic factor	14573(Tax:10090)	14573(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA following mechanical injury to mouse striatum .
9870346	0	GDNF	62,66	glial_cell_line-derived_neurotrophic_factor	17,60	GDNF	glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Up-regulation of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- expression in regenerating muscle fibers in neuromuscular_diseases .
9972821	0	GDNF	72,76	glial_cell_line-derived_neurotrophic_factor	27,70	GDNF	glial cell line-derived neurotrophic factor	2668	2668	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differential regulation of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- expression in human neuroblastoma and glioblastoma cell lines .
19741142	0	GDNF	211,215	neural_cell_adhesion_molecule	59,88	GDNF	neural cell adhesion molecule	2668	4684	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Role of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- - neural_cell_adhesion_molecule -LRB- NCAM -RRB- interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF .
7703397	0	GDNF	45,49	neurotrophic_factor	58,77	GDNF	neurotrophic factor	25453(Tax:10116)	81737(Tax:10116)	Gene	Gene	Glial_cell_line-derived_neurotrophic_factor|appos|START_ENTITY Glial_cell_line-derived_neurotrophic_factor|dep|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- , a new neurotrophic_factor for motoneurones .
7790368	0	GDNF	51,55	neurotrophic_factor	63,82	GDNF	neurotrophic factor	2668	9048	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Peripheral expression and biological activities of GDNF , a new neurotrophic_factor for avian and mammalian peripheral neurons .
21200028	0	GDNF	64,68	syndecan-3	29,39	GDNF	syndecan-3	14573(Tax:10090)	20970(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF , neurturin , and artemin .
19429458	0	GDNF-inducible_transcription_factor	18,53	GIF	55,58	GDNF-inducible transcription factor	GIF	14603(Tax:10090)	14603(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Activation of the GDNF-inducible_transcription_factor -LRB- GIF -RRB- gene promoter by glucocorticoid and progesterone .
8674117	0	GDNFR-alpha	74,85	GDNF	108,112	GDNFR-alpha	GDNF	25454(Tax:10116)	25453(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha , a novel receptor for GDNF .
22902531	0	GDNF_family_neurotrophic_factor_receptor_a1	54,97	GFRa1	99,104	GDNF family neurotrophic factor receptor a1	GFRa1	395994(Tax:9031)	395994(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Neurogenin2 expression together with NeuroM regulates GDNF_family_neurotrophic_factor_receptor_a1 -LRB- GFRa1 -RRB- expression in the embryonic spinal cord .
16431922	0	GEC1	0,4	kappa_opioid_receptor	24,45	GEC1	kappa opioid receptor	23710	4986	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GEC1 interacts with the kappa_opioid_receptor and enhances expression of the receptor .
25750125	0	GEF	40,43	Asef2	45,50	GEF	Asef2	5923	221178	Gene	Gene	Factor|appos|START_ENTITY END_ENTITY|nsubj|Factor	The Guanine Nucleotide Exchange Factor -LRB- GEF -RRB- Asef2 Promotes Dendritic Spine Formation via Rac Activation and Spinophilin-Dependent Targeting .
20842712	0	GEF	18,21	Intersectin_1	34,47	GEF	Intersectin 1	5923	6453	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Autoinhibition of GEF activity in Intersectin_1 is mediated by the short SH3-DH domain linker .
24740538	0	GEF	61,64	LARG	66,70	GEF	LARG	16800(Tax:10090)	69632(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Jun_kinase-induced overexpression of leukemia-associated Rho GEF -LRB- LARG -RRB- mediates sustained hypercontraction of longitudinal smooth muscle in inflammation .
24957337	0	GEF	32,35	Rabaptin-5	50,60	GEF	Rabaptin-5	9181	9135	Gene	Gene	mechanism|nmod|START_ENTITY activation|nsubj|mechanism activation|nmod|END_ENTITY	Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 .
20375281	0	GEF	21,24	Trs85	0,5	GEF	Trs85	9181	22878	Gene	Gene	directs|dobj|START_ENTITY directs|nsubj|END_ENTITY	Trs85 directs a Ypt1 GEF , TRAPPIII , to the phagophore to promote autophagy .
22456277	0	GEF	5,8	Vav1	0,4	GEF	Vav1	16800(Tax:10090)	22324(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Vav1 GEF activity is required for T cell mediated allograft rejection .
21406564	0	GEF-H1	113,119	Rac1	56,60	GEF-H1	Rac1	16800(Tax:10090)	19353(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY regulates|nmod|interaction regulates|dobj|activity activity|amod|END_ENTITY	Calpain-6 , a microtubule-stabilizing protein , regulates Rac1 activity and cell motility through interaction with GEF-H1 .
17488622	0	GEF-H1	0,6	RhoA	27,31	GEF-H1	RhoA	9181	387	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activation activation|compound|END_ENTITY	GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases .
26759237	0	GEF-H1	140,146	RhoB	147,151	GEF-H1	RhoB	9181	388	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small_Cell_Lung_Cancer Cells by Inhibiting YAP Activation through the GEF-H1 / RhoB Pathway .
21352810	0	GEFH1	0,5	ASAP1	12,17	GEFH1	ASAP1	9181	50807	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	GEFH1 binds ASAP1 and regulates podosome formation .
18541910	0	GEFT	29,33	Bves	0,4	GEFT	Bves	115557	11149	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Bves directly interacts with GEFT , and controls cell shape and movement through regulation of Rac1/Cdc42 activity .
16581976	0	GEFmeso	41,48	Cdc42	110,115	GEFmeso	Cdc42	37134(Tax:7227)	32981(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Novel guanine_nucleotide exchange factor GEFmeso of Drosophila_melanogaster interacts with Ral and Rho GTPase Cdc42 .
24130856	0	GEM-1	69,74	CATP-6	0,6	GEM-1	CATP-6	181458(Tax:6239)	177822(Tax:6239)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	CATP-6 , a C. _ elegans ortholog of ATP13A2 PARK9 , positively regulates GEM-1 , an SLC16A transporter .
20403813	0	GEMIN2	0,6	RAD51	32,37	GEMIN2	RAD51	8487	5888	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|nmod|END_ENTITY	GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination .
16685387	0	GEP	0,3	p53	30,33	GEP	p53	2896	7157	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	GEP associates with wild-type p53 in hepatocellular_carcinoma .
18084281	0	GEP100	0,6	epidermal_growth_factor_receptor	13,45	GEP100	epidermal growth factor receptor	9922	1956	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	GEP100 links epidermal_growth_factor_receptor signalling to Arf6 activation to induce breast_cancer_invasion .
8984045	0	GER	40,43	gastroesophageal_reflux	15,38	GER	gastroesophageal reflux	59330	59330	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of gastroesophageal_reflux -LRB- GER -RRB- with bronchial_asthma .
7422059	0	GFA	105,108	alpha-albumin	90,103	GFA	alpha-albumin	297417(Tax:10116)	282708(Tax:10116)	Gene	Gene	determination|appos|START_ENTITY determination|nmod|END_ENTITY	Immunochemical determination and immunocytological localization of brain-specific protein alpha-albumin -LRB- GFA -RRB- in isolated astrocytes .
21960009	0	GFAP	134,138	14-3-3_epsilon	98,112	GFAP	14-3-3 epsilon	14580(Tax:10090)	22627(Tax:10090)	Gene	Gene	increase|nmod|START_ENTITY increase|amod|END_ENTITY	A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3_epsilon and late increase of GFAP .
17032734	0	GFAP	91,95	14-3-3gamma	0,11	GFAP	14-3-3gamma	2670	7532	Gene	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	14-3-3gamma affects dynamics and integrity of glial filaments by binding to phosphorylated GFAP .
20946255	0	GFAP	48,52	AP-1	20,24	GFAP	AP-1	2670	3726	Gene	Gene	promoter|compound|START_ENTITY element|nmod|promoter element|compound|END_ENTITY	A novel polymorphic AP-1 binding element of the GFAP promoter is associated with different allelic transcriptional activities .
9051264	0	GFAP	13,17	CNTF	0,4	GFAP	CNTF	24387(Tax:10116)	25707(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	CNTF induces GFAP in a S-100 alpha brain cell population : the pattern of CNTF-alpha R suggests an indirect mode of action .
15723074	0	GFAP	28,32	EIF2B5	0,6	GFAP	EIF2B5	2670	8893	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	EIF2B5 mutations compromise GFAP + astrocyte generation in vanishing_white_matter_leukodystrophy .
12931206	0	GFAP	23,27	GFAP	93,97	GFAP	GFAP	2670	2670	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Neuronal expression of GFAP in patients with Alzheimer_pathology and identification of novel GFAP splice forms .
12931206	0	GFAP	93,97	GFAP	23,27	GFAP	GFAP	2670	2670	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Neuronal expression of GFAP in patients with Alzheimer_pathology and identification of novel GFAP splice forms .
23928073	0	GFAP	14,18	IL-1b	0,5	GFAP	IL-1b	24387(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-1b induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFkB/Ca - calmodulin/ERK mitogen-activated protein kinase signaling pathway .
24269336	0	GFAP	16,20	MeCP2	0,5	GFAP	MeCP2	24387(Tax:10116)	29386(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MeCP2 regulates GFAP expression within the developing brain .
26164608	0	GFAP	136,140	NeuN	61,65	GFAP	NeuN	24387(Tax:10116)	287847(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Upregulation effects of Tanshinone_IIA on the expressions of NeuN , Nissl body , and IkB and downregulation effects on the expressions of GFAP and NF-kB in the brain tissues of rat models of Alzheimer 's _ disease .
12536397	0	GFAP	16,20	PCNA	22,26	GFAP	PCNA	2670	5111	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	-LSB- The changes of GFAP , PCNA after brain_contusion : an immunohistochemical study in forensic pathology -RSB- .
9920729	0	GFAP	201,205	S100A1	173,179	GFAP	S100A1	2670	6271	Gene	Gene	polymerization|compound|START_ENTITY effect|nmod|polymerization effect|compound|END_ENTITY	Role of the C-terminal extension in the interaction of S100A1 with GFAP , tubulin , the S100A1 - and S100B-inhibitory peptide , TRTK-12 , and a peptide derived from p53 , and the S100A1 inhibitory effect on GFAP polymerization .
9920729	0	GFAP	67,71	S100A1	55,61	GFAP	S100A1	2670	6271	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the C-terminal extension in the interaction of S100A1 with GFAP , tubulin , the S100A1 - and S100B-inhibitory peptide , TRTK-12 , and a peptide derived from p53 , and the S100A1 inhibitory effect on GFAP polymerization .
10740226	0	GFAP	48,52	glial_fibrillary_acidic_protein	15,46	GFAP	glial fibrillary acidic protein	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice .
10799667	0	GFAP	66,70	glial_fibrillary_acidic_protein	33,64	GFAP	glial fibrillary acidic protein	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Ovarian cycle-related changes of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- immunoreactivity in the rat interpeduncular_nucleus .
12083337	0	GFAP	110,114	glial_fibrillary_acidic_protein	77,108	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Testosterone treatment attenuates the effects of facial nerve transection on glial_fibrillary_acidic_protein -LRB- GFAP -RRB- levels in the hamster facial motor nucleus .
1283203	0	GFAP	47,51	glial_fibrillary_acidic_protein	14,45	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- by cultured angiofibroma stroma cells from patients with tuberous_sclerosis .
1457987	0	GFAP	69,73	glial_fibrillary_acidic_protein	36,67	GFAP	glial fibrillary acidic protein	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in rat pineal stalk astrocytes .
15007738	0	GFAP	51,55	glial_fibrillary_acidic_protein	18,49	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of CSF glial_fibrillary_acidic_protein -LRB- GFAP -RRB- as a putative marker for HIV-associated dementia .
16202357	0	GFAP	48,52	glial_fibrillary_acidic_protein	15,46	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- with grading of the neuroglial_tumours .
1723659	0	GFAP	65,69	glial_fibrillary_acidic_protein	32,63	GFAP	glial fibrillary acidic protein	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Developmental expression of the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- gene in the mouse retina .
1772810	0	GFAP	75,79	glial_fibrillary_acidic_protein	42,73	GFAP	glial fibrillary acidic protein	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Reduction of ocular blood flow results in glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in rat retinal M ller cells .
1779136	0	GFAP	58,62	glial_fibrillary_acidic_protein	25,56	GFAP	glial fibrillary acidic protein	101081938	101081938	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Comparative study of the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in toad , kitten and cat sensory ganglia .
1782546	0	GFAP	78,82	glial_fibrillary_acidic_protein	45,76	GFAP	glial fibrillary acidic protein	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Insulin influences astroglial morphology and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in organotypic cultures .
18483855	0	GFAP	44,48	glial_fibrillary_acidic_protein	11,42	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in glial_fibrillary_acidic_protein -LRB- GFAP -RRB- immonureactivity reflect neuronal states .
2229641	0	GFAP	49,53	glial_fibrillary_acidic_protein	16,47	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in the intermediate filaments of the cultured cells from a patient with tuberous_sclerosis .
22362931	0	GFAP	69,73	glial_fibrillary_acidic_protein	36,67	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Aberrant E-cadherin , b-catenin , and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in canine choroid_plexus_tumors .
23626774	0	GFAP	49,53	glial_fibrillary_acidic_protein	16,47	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Blood levels of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in patients with neurological_diseases .
23991052	0	GFAP	68,72	glial_fibrillary_acidic_protein	35,66	GFAP	glial fibrillary acidic protein	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternative mRNA splicing from the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- gene generates isoforms with distinct subcellular mRNA localization patterns in astrocytes .
26518540	0	GFAP	65,69	glial_fibrillary_acidic_protein	32,63	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Prospective evaluation of serum glial_fibrillary_acidic_protein -LRB- GFAP -RRB- as a diagnostic marker for glioblastoma .
2732098	0	GFAP	81,85	glial_fibrillary_acidic_protein	48,79	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunogold electron microscopic localization of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in neurohypophyseal pituicytes and tanycytes of the Mongolian gerbil -LRB- Meriones unguiculatus -RRB- .
2989328	0	GFAP	47,51	glial_fibrillary_acidic_protein	14,45	GFAP	glial fibrillary acidic protein	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in CNS development and in pathological states .
3124642	0	GFAP	47,51	glial_fibrillary_acidic_protein	14,45	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in peripheral_nerve_sheath_tumors .
3886073	0	GFAP	68,72	glial_fibrillary_acidic_protein	35,66	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in the area postrema of the cat .
4056822	0	GFAP	75,79	glial_fibrillary_acidic_protein	42,73	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	High cerebrospinal fluid concentration of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in patients with normal pressure hydrocephalus .
624958	0	GFAP	50,54	glial_fibrillary_acidic_protein	17,48	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in human brain_tumors .
6339423	0	GFAP	44,48	glial_fibrillary_acidic_protein	11,42	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A study of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in childhood brain_tumours .
7541474	0	GFAP	73,77	glial_fibrillary_acidic_protein	40,71	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	PKA and PKC activation induces opposite glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression and morphology changes in a glioblastoma multiform cell line of clonal origin .
7782103	0	GFAP	94,98	glial_fibrillary_acidic_protein	61,92	GFAP	glial fibrillary acidic protein	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Indicator expression directed by regulatory sequences of the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- gene : in vivo comparison of distinct GFAP-lacZ transgenes .
8261795	0	GFAP	59,63	glial_fibrillary_acidic_protein	26,57	GFAP	glial fibrillary acidic protein	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Muller cell expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in RPE-cell transplanted retinas of RCS dystrophic rats .
8552312	0	GFAP	60,64	glial_fibrillary_acidic_protein	27,58	GFAP	glial fibrillary acidic protein	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in the retinae and visual cortices of rats with experimental renal hypertension .
8849315	0	GFAP	93,97	glial_fibrillary_acidic_protein	60,91	GFAP	glial fibrillary acidic protein	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Distribution of growth associated protein -LRB- B-50 / GAP-43 -RRB- and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- immunoreactivity in rat homotopic olfactory bulb transplants .
9151729	0	GFAP	119,123	glial_fibrillary_acidic_protein	86,117	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Neuritic outgrowth associated with astroglial phenotypic changes induced by antisense glial_fibrillary_acidic_protein -LRB- GFAP -RRB- mRNA in injured neuron-astrocyte cocultures .
9518557	0	GFAP	55,59	glial_fibrillary_acidic_protein	22,53	GFAP	glial fibrillary acidic protein	2670	2670	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of c-Fos and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression following topical application of potassium_chloride -LRB- KCl -RRB- to the brain surface .
17940874	0	GFAP	17,21	iNOS	11,15	GFAP	iNOS	24387(Tax:10116)	24599(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes in iNOS , GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress .
20814740	0	GFAP	28,32	vimentin	34,42	GFAP	vimentin	2670	7431	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Alpha-lipoic_acid modulates GFAP , vimentin , nestin , cyclin_D1 and MAP-kinase expression in astroglial cell cultures .
3134930	0	GFAP	79,83	vimentin	69,77	GFAP	vimentin	24387(Tax:10116)	81818(Tax:10116)	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	-LSB- Immunohistochemical study of developing rat embryo -- localization of vimentin , GFAP , neurofilament protein within rat embryo central nervous system -RSB- .
21958546	0	GFAT	118,122	glutamine_fructose-6-phosphate_amidotransferase	69,116	GFAT	glutamine fructose-6-phosphate amidotransferase	297417(Tax:10116)	297417(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of 1-arylcarbonyl-6 ,7 - dimethoxyisoquinoline derivatives as glutamine_fructose-6-phosphate_amidotransferase -LRB- GFAT -RRB- inhibitors .
11696536	0	GFI-1B	60,66	Socs	14,18	GFI-1B	Socs	14582(Tax:10090)	12700(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of Socs gene expression by the proto-oncoprotein GFI-1B : two routes for STAT5 target gene induction by erythropoietin .
25447538	0	GFI1	25,29	NLRP3	51,56	GFI1	NLRP3	2672	114548	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	The transcription factor GFI1 negatively regulates NLRP3 inflammasome activation in macrophages .
17156408	0	GFI1B	35,40	Growth_factor-independent_1B	0,28	GFI1B	Growth factor-independent 1B	8328	8328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Growth_factor-independent_1B gene -LRB- GFI1B -RRB- is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate .
15308130	0	GFPT1	84,89	glutamine-fructose-6-phosphate_amidotransferase_1	33,82	GFPT1	glutamine-fructose-6-phosphate amidotransferase 1	2673	2673	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular screening of the human glutamine-fructose-6-phosphate_amidotransferase_1 -LRB- GFPT1 -RRB- gene and association studies with diabetes and diabetic_nephropathy .
20369355	0	GFRA2	62,67	Glial_cell_line-derived_neurotrophic_factor	0,43	GFRA2	Glial cell line-derived neurotrophic factor	2675	2668	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor receptor alpha 2 -LRB- GFRA2 -RRB- gene is associated with tardive_dyskinesia .
15448133	0	GFRP	76,80	GTP_cyclohydrolase_I	52,72	GFRP	GTP cyclohydrolase I	2644	2643	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis of biopterin-induced inhibition of GTP_cyclohydrolase_I by GFRP , its feedback regulatory protein .
18822276	0	GFR_alpha1	110,120	GDNF	95,99	GFR alpha1	GDNF	14585(Tax:10090)	14573(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Differential effects of the dopamine neurotoxin MPTP in animals with a partial deletion of the GDNF receptor , GFR_alpha1 , gene .
10069331	0	GFR_alpha2	95,105	neurturin	120,129	GFR alpha2	neurturin	14586(Tax:10090)	18188(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	Retarded_growth and deficits_in_the_enteric_and_parasympathetic_nervous_system in mice lacking GFR_alpha2 , a functional neurturin receptor .
12433948	0	GFR_alpha2	0,10	neurturin	11,20	GFR alpha2	neurturin	14586(Tax:10090)	18188(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signalling signalling|compound|END_ENTITY	GFR_alpha2 / neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons .
12701883	0	GFR_alpha_1	67,78	ret	101,104	GFR alpha 1	ret	14585(Tax:10090)	19713(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Internalization of glial cell-derived neurotrophic factor receptor GFR_alpha_1 in the absence of the ret tyrosine kinase coreceptor .
22902531	0	GFRa1	99,104	GDNF_family_neurotrophic_factor_receptor_a1	54,97	GFRa1	GDNF family neurotrophic factor receptor a1	395994(Tax:9031)	395994(Tax:9031)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Neurogenin2 expression together with NeuroM regulates GDNF_family_neurotrophic_factor_receptor_a1 -LRB- GFRa1 -RRB- expression in the embryonic spinal cord .
21865882	0	GFRa1	74,79	Nurr1	87,92	GFRa1	Nurr1	25454(Tax:10116)	54278(Tax:10116)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	Signaling of glial_cell_line-derived_neurotrophic_factor and its receptor GFRa1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson_disease .
9647690	0	GFRalpha-4	0,10	GDNF	18,22	GFRalpha-4	GDNF	395839(Tax:9031)	395569(Tax:9031)	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	GFRalpha-4 , a new GDNF family receptor .
12884298	0	GFRalpha1	86,95	glial_cell_line-derived_neurotrophic_factor	24,67	GFRalpha1	glial cell line-derived neurotrophic factor	14585(Tax:10090)	14573(Tax:10090)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of glial_cell_line-derived_neurotrophic_factor and its receptor , GFRalpha1 , in survival and maturation of thymocytes .
18353777	0	GFRalpha1	14,23	neural_cell_adhesion_molecule	38,67	GFRalpha1	neural cell adhesion molecule	2674	4684	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Insights into GFRalpha1 regulation of neural_cell_adhesion_molecule -LRB- NCAM -RRB- function from structure-function analysis of the NCAM/GFRalpha1 receptor complex .
16765900	0	GFRalpha3	49,58	artemin	13,20	GFRalpha3	artemin	2676	9048	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Structure of artemin complexed with its receptor GFRalpha3 : convergent recognition of glial_cell_line-derived_neurotrophic_factors .
9448325	0	GFRalpha3	29,38	glial_cell_line-derived_neurotrophic_factor	42,85	GFRalpha3	glial cell line-derived neurotrophic factor	14587(Tax:10090)	14573(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	Expression and regulation of GFRalpha3 , a glial_cell_line-derived_neurotrophic_factor family receptor .
14973137	0	GGA1	0,4	AP-1	40,44	GGA1	AP-1	26088	3727	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GGA1 interacts with the adaptor protein AP-1 through a WNSF sequence in its hinge region .
14636058	0	GGA1	29,33	rabaptin-5	50,60	GGA1	rabaptin-5	26088	9135	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle .
17786385	0	GGCX	85,89	gamma-glutamyl_carboxylase	52,78	GGCX	gamma-glutamyl carboxylase	2677	2677	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High-resolution SNP and haplotype maps of the human gamma-glutamyl_carboxylase gene -LRB- GGCX -RRB- and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population .
10234512	0	GGN	14,17	androgen_receptor	39,56	GGN	androgen receptor	199720	367	Gene	Gene	repeats|compound|START_ENTITY repeats|nmod|gene gene|compound|END_ENTITY	-LRB- CAG -RRB- nCAA and GGN repeats in the human androgen_receptor gene are not associated with prostate_cancer in a French-German population .
12802043	0	GGN	64,67	androgen_receptor	46,63	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nsubj|association association|nmod|mutations mutations|nmod|END_ENTITY	No association between mutations in the human androgen_receptor GGN repeat and inter-sex conditions .
15472213	0	GGN	49,52	androgen_receptor	74,91	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Linkage between cryptorchidism , hypospadias , and GGN repeat length in the androgen_receptor gene .
16809273	0	GGN	36,39	androgen_receptor	18,35	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	No association of androgen_receptor GGN repeat length polymorphism with infertility in Indian men .
16957138	0	GGN	40,43	androgen_receptor	70,87	GGN	androgen receptor	199720	367	Gene	Gene	repeats|compound|START_ENTITY Association|appos|repeats Association|nmod|exon exon|nmod|gene gene|compound|END_ENTITY	Association of long polyglycine tracts -LRB- GGN repeats -RRB- in exon 1 of the androgen_receptor gene with cryptorchidism and penile_hypospadias in Iranian patients .
16969583	0	GGN	0,3	androgen_receptor	58,75	GGN	androgen receptor	199720	367	Gene	Gene	repeat|nsubj|START_ENTITY repeat|nmod|gene gene|compound|END_ENTITY	GGN repeat length and GGN/CAG haplotype variations in the androgen_receptor gene and prostate_cancer risk in south Indian men .
17197074	0	GGN	62,65	androgen_receptor	44,61	GGN	androgen receptor	199720	367	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Functional in vitro characterisation of the androgen_receptor GGN polymorphism .
17601880	0	GGN	42,45	androgen_receptor	60,77	GGN	androgen receptor	199720	367	Gene	Gene	repeat|compound|START_ENTITY repeat|nmod|gene gene|compound|END_ENTITY	The two most common alleles of the coding GGN repeat in the androgen_receptor gene cause differences in protein function .
19095061	0	GGN	22,25	androgen_receptor	63,80	GGN	androgen receptor	199720	367	Gene	Gene	repeats|compound|START_ENTITY repeats|nmod|exon-1 exon-1|nmod|gene gene|compound|END_ENTITY	Short alleles of both GGN and CAG repeats at the exon-1 of the androgen_receptor gene are associated to increased PSA staining and a higher Gleason score in human prostatic_cancer .
19159685	0	GGN	4,7	androgen_receptor	58,75	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nmod|exon-1 exon-1|nmod|gene gene|compound|END_ENTITY	The GGN and CAG repeat polymorphisms in the exon-1 of the androgen_receptor gene are , respectively , associated with insulin resistance in men and with dyslipidemia in women .
19383805	0	GGN	43,46	androgen_receptor	20,37	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|gene gene|compound|END_ENTITY	Small effect of the androgen_receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men .
24855036	0	GGN	58,61	androgen_receptor	28,45	GGN	androgen receptor	199720	367	Gene	Gene	n|dep|START_ENTITY n|nsubj|survey survey|nmod|END_ENTITY	A pharmacogenetic survey of androgen_receptor -LRB- CAG -RRB- n and -LRB- GGN -RRB- n polymorphisms in patients experiencing long term side effects after finasteride discontinuation .
25027083	0	GGN	45,48	androgen_receptor	21,38	GGN	androgen receptor	199720	367	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Associations between androgen_receptor CAG _ GGN repeat polymorphism _ recurrent spontaneous_abortions in Chinese women .
26221130	0	GGN	33,36	androgen_receptor	15,32	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of androgen_receptor GGN repeat length polymorphism and male_infertility in Khuzestan , Iran .
26221130	0	GGN	33,36	androgen_receptor	15,32	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of androgen_receptor GGN repeat length polymorphism and male_infertility in Khuzestan , Iran .
9385367	0	GGN	41,44	androgen_receptor	81,98	GGN	androgen receptor	199720	367	Gene	Gene	n|appos|START_ENTITY variants|nmod|n trinucleotide|nsubj|variants trinucleotide|dobj|repeat repeat|nmod|gene gene|compound|END_ENTITY	Codon-usage variants in the polymorphic -LRB- GGN -RRB- n trinucleotide repeat of the human androgen_receptor gene .
9610786	0	GGN	27,30	androgen_receptor	4,21	GGN	androgen receptor	199720	367	Gene	Gene	START_ENTITY|nsubj|gene gene|compound|END_ENTITY	The androgen_receptor gene GGN microsatellite and prostate_cancer risk .
19208545	0	GGNBP1	60,66	gametogenetin-binding_protein_1	27,58	GGNBP1	gametogenetin-binding protein 1	70772(Tax:10090)	70772(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel potential role for gametogenetin-binding_protein_1 -LRB- GGNBP1 -RRB- in mitochondrial morphogenesis during spermatogenesis in mice .
21983072	0	GGPPS	0,5	EGR-1	13,18	GGPPS	EGR-1	9453	1958	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	GGPPS , a new EGR-1 target gene , reactivates ERK_1 / 2 signaling through increasing Ras prenylation .
7841659	0	GGT	28,31	Gamma-glutamyl_transferase	0,26	GGT	Gamma-glutamyl transferase	116568(Tax:10116)	116568(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Gamma-glutamyl_transferase -LRB- GGT -RRB- activity and biochemical characterization of rat visceral yolk-sac during gestation with or without trypan_blue exposure .
21797800	0	GGT	34,37	gamma-glutamyl_transferase	6,32	GGT	gamma-glutamyl transferase	2678	2678	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum gamma-glutamyl_transferase -LRB- GGT -RRB- levels and inflammatory activity in patients with non-dipper hypertension .
10572675	0	GGT	75,78	gamma-glutamyl_transpeptidase	44,73	GGT	gamma-glutamyl transpeptidase	92086	92086	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	-LSB- Relationship between methylation status of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- genes and abnormal expression of its enzyme proteins in tissues of human hepatomas -RSB- .
15893589	0	GGT	48,51	gamma-glutamyl_transpeptidase	17,46	GGT	gamma-glutamyl transpeptidase	92086	92086	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Up-regulation of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- activity in growth perturbed C6 astrocytes .
1970549	0	GGT	50,53	gamma-glutamyl_transpeptidase	19,48	GGT	gamma-glutamyl transpeptidase	92086	92086	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of human gamma-glutamyl_transpeptidase -LRB- GGT -RRB- during the fetal development of liver .
7854499	0	GGT	74,77	gamma-glutamyl_transpeptidase	43,72	GGT	gamma-glutamyl transpeptidase	14598(Tax:10090)	14598(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Enhanced erythropoietin and suppression of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- activity in murine lymphoma following administration of vanadium .
1679348	0	GGT	41,44	gamma-glutamyltranspeptidase	11,39	GGT	gamma-glutamyltranspeptidase	116568(Tax:10116)	116568(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Peripartal gamma-glutamyltranspeptidase -LRB- GGT -RRB- activity in the mammary glands of pregnant Uje : WIST rats .
1687660	0	GGT	195,198	gamma-glutamyltranspeptidase	165,193	GGT	gamma-glutamyltranspeptidase	116568(Tax:10116)	116568(Tax:10116)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The effect of hadacidin , ultraviolet irradiation of blood -LRB- UVB -RRB- and thiamine on the prenatal development of Uje : WIST rats : correlation with the hepatic activity of gamma-glutamyltranspeptidase -LRB- GGT -RRB- -RSB- .
20484958	0	GGT1	84,88	gamma-glutamyltransferase_1	55,82	GGT1	gamma-glutamyltransferase 1	2678	2678	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pooling-based genome-wide association study implicates gamma-glutamyltransferase_1 -LRB- GGT1 -RRB- gene in pancreatic carcinogenesis .
8156914	0	GH	77,79	CYP2C	27,32	GH	CYP2C	81668(Tax:10116)	29277(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY expression|nmod|growth_hormone expression|compound|END_ENTITY	The sensitivity of hepatic CYP2C gene expression to baseline growth_hormone -LRB- GH -RRB- bioactivity in dwarf rats : effects of GH-binding protein in vivo .
14763922	0	GH	48,50	GH	75,77	GH	GH	2688	2688	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH , pituitary_transcription_factor-1 , GHRH-receptor , GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells .
14763922	0	GH	75,77	GH	48,50	GH	GH	2688	2688	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH , pituitary_transcription_factor-1 , GHRH-receptor , GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells .
3979800	0	GH	172,174	GH	184,186	GH	GH	2688	2688	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Comparative effects of homoplastic pituitary pars distalis homogenate -LRB- PDH -RRB- , pregnant mare serum gonadotrophin -LRB- PMSG -RRB- , human_chorionic_gonadotrophin -LRB- HCG -RRB- , growth_hormone -LRB- GH -RRB- , PMSG + GH , and HCG + GH on oocyte recruitment and development in the long-term hypophysectomized frog , Rana cyanophlyctis -LRB- Schn -RRB- .
3979800	0	GH	184,186	GH	172,174	GH	GH	2688	2688	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Comparative effects of homoplastic pituitary pars distalis homogenate -LRB- PDH -RRB- , pregnant mare serum gonadotrophin -LRB- PMSG -RRB- , human_chorionic_gonadotrophin -LRB- HCG -RRB- , growth_hormone -LRB- GH -RRB- , PMSG + GH , and HCG + GH on oocyte recruitment and development in the long-term hypophysectomized frog , Rana cyanophlyctis -LRB- Schn -RRB- .
2040861	0	GH	69,71	GH-receptor	76,87	GH	GH-receptor	378781(Tax:9031)	408184(Tax:9031)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of hypophysectomy and acute administration of growth_hormone -LRB- GH -RRB- on GH-receptor binding in chick liver membranes .
11549707	0	GH	49,51	GH-releasing_hormone	82,102	GH	GH-releasing hormone	2688	2691	Gene	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	A low dose of ghrelin stimulates growth_hormone -LRB- GH -RRB- release synergistically with GH-releasing_hormone in humans .
12840904	0	GH	29,31	GH-releasing_hormone	53,73	GH	GH-releasing hormone	2688	2691	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
10594518	0	GH	141,143	GHRH	67,71	GH	GHRH	2688	2691	Gene	Gene	roles|appos|START_ENTITY roles|nmod|growth_hormone-releasing_hormone growth_hormone-releasing_hormone|dep|END_ENTITY	The relative roles of continuous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- and intermittent somatostatin -LRB- 1-14 -RRB- -LRB- SS -RRB- in growth_hormone -LRB- GH -RRB- pulse generation : studies in normal and post cranial irradiated individuals .
10770183	0	GH	29,31	GHRH	168,172	GH	GHRH	2688	2691	Gene	Gene	Diagnosis|appos|START_ENTITY _|nsubj|Diagnosis _|nmod|hypothalamic-pituitary_disorders hypothalamic-pituitary_disorders|dep|comparison comparison|nmod|results results|acl|using using|dobj|hormone hormone|appos|END_ENTITY	Diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in adults with hypothalamic-pituitary_disorders : comparison of test results using pyridostigmine plus GH-releasing hormone -LRB- GHRH -RRB- , clonidine plus GHRH , and insulin-induced hypoglycemia as GH secretagogues .
11455330	0	GH	27,29	GHRH	69,73	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- and growth_hormone_releasing_hormone -LRB- GHRH -RRB- on progesterone and estradiol release from cultured rat granulosa cells .
12446584	0	GH	28,30	GHRH	173,177	GH	GHRH	2688	2691	Gene	Gene	Ghrelin|appos|START_ENTITY secretagogues|nsubj|Ghrelin secretagogues|dep|induced induced|advcl|expressing expressing|dobj|END_ENTITY	Ghrelin and growth_hormone -LRB- GH -RRB- secretagogues potentiate GH-releasing_hormone -LRB- GHRH -RRB- - induced cyclic_adenosine_3 ' ,5 ' - monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors .
12446584	0	GH	28,30	GHRH	79,83	GH	GHRH	2688	2691	Gene	Gene	Ghrelin|appos|START_ENTITY secretagogues|nsubj|Ghrelin secretagogues|dep|induced induced|nsubj|GH-releasing_hormone GH-releasing_hormone|appos|END_ENTITY	Ghrelin and growth_hormone -LRB- GH -RRB- secretagogues potentiate GH-releasing_hormone -LRB- GHRH -RRB- - induced cyclic_adenosine_3 ' ,5 ' - monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors .
12840904	0	GH	29,31	GHRH	75,79	GH	GHRH	2688	2691	Gene	Gene	effect|appos|START_ENTITY effect|appos|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
12938517	0	GH	47,49	GHRH	14,18	GH	GHRH	2688	2691	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of GHRH , GHRP-2 and somatostatin on GH secretion by fetal pituitary .
1454656	0	GH	31,33	GHRH	47,51	GH	GHRH	2688	2691	Gene	Gene	Inhibition|appos|START_ENTITY response|nsubj|Inhibition response|xcomp|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
14763922	0	GH	48,50	GHRH	10,14	GH	GHRH	2688	2691	Gene	Gene	secretion|compound|START_ENTITY vitro|nmod|secretion mRNAs|amod|vitro Effect|nmod|mRNAs Effect|nmod|END_ENTITY	Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH , pituitary_transcription_factor-1 , GHRH-receptor , GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells .
14763922	0	GH	75,77	GHRH	10,14	GH	GHRH	2688	2691	Gene	Gene	secretion|nmod|START_ENTITY vitro|nmod|secretion mRNAs|amod|vitro Effect|nmod|mRNAs Effect|nmod|END_ENTITY	Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH , pituitary_transcription_factor-1 , GHRH-receptor , GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells .
15564325	0	GH	41,43	GHRH	136,140	GH	GHRH	14599(Tax:10090)	14601(Tax:10090)	Gene	Gene	reversibility|appos|START_ENTITY _|nsubj|reversibility _|nmod|analog analog|compound|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15564325	0	GH	41,43	GHRH	85,89	GH	GHRH	14599(Tax:10090)	14601(Tax:10090)	Gene	Gene	reversibility|appos|START_ENTITY _|nsubj|reversibility _|nmod|mouse mouse|appos|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15638293	0	GH	16,18	GHRH	138,142	GH	GHRH	2688	2691	Gene	Gene	Growth_hormone|dep|START_ENTITY peaks|amod|Growth_hormone peaks|dep|analysis analysis|nmod|variables variables|acl|provided provided|nmod|test test|compound|END_ENTITY	Growth_hormone -LRB- GH -RRB- peaks versus areas under the curve in the diagnosis of adult GH_deficiency : analysis of the variables provided by the GHRH + GHRP-6 test .
1577400	0	GH	61,63	GHRH	77,81	GH	GHRH	2688	2691	Gene	Gene	responses|compound|START_ENTITY increases|dobj|responses increases|xcomp|END_ENTITY	alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects .
16712669	0	GH	60,62	GHRH	99,103	GH	GHRH	2688	2691	Gene	Gene	secretion|appos|START_ENTITY obesity|nmod|secretion Effect|nmod|obesity elicited|nsubj|Effect elicited|nmod|test test|compound|END_ENTITY	Effect of obesity and morbid obesity on the growth_hormone -LRB- GH -RRB- secretion elicited by the combined GHRH + GHRP-6 test .
16835832	0	GH	139,141	GHRH	61,65	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	reserve|compound|START_ENTITY study|nmod|reserve secretagogue|nmod|study secretagogue|nsubj|END_ENTITY	Recruiting of somatotroph cells after combined somatostatin , GHRH and growth_hormone -LRB- GH -RRB- secretagogue stimulation in a study of pituitary GH reserve in prepuberal female rats .
18095239	6	GH	1154,1156	GHRH	1169,1173	GH	GHRH	2688	2691	Gene	Gene	response|compound|START_ENTITY increased|dobj|response increased|advcl|END_ENTITY	In LC , PD administration markedly increased the GH response to GHRH -LRB- GH peak : 98.0 + / -19.7 ng/ml ; +240 % vs. GHRH alone -RRB- .
19342191	0	GH	37,39	GHRH	62,66	GH	GHRH	443329(Tax:9940)	780526(Tax:9940)	Gene	Gene	response|compound|START_ENTITY modulates|dobj|response modulates|xcomp|END_ENTITY	Ghrelin differentially modulates the GH secretory response to GHRH between the fed and fasted states in sheep .
1943453	0	GH	23,25	GHRH	133,137	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY secretion|nsubj|growth_hormone secretion|dep|END_ENTITY	Robust growth_hormone -LRB- GH -RRB- secretion in aged female rats co-administered GH-releasing hexapeptide -LRB- GHRP-6 -RRB- and GH-releasing_hormone -LRB- GHRH -RRB- .
2104760	0	GH	56,58	GHRH	71,75	GH	GHRH	2688	2691	Gene	Gene	response|compound|START_ENTITY suppress|dobj|response suppress|xcomp|END_ENTITY	Failure of glucose infusion to suppress the exaggerated GH response to GHRH in patients with anorexia_nervosa .
2273206	0	GH	78,80	GHRH	115,119	GH	GHRH	2688	2691	Gene	Gene	Interaction|appos|START_ENTITY induced|nsubj|Interaction induced|nmod|GH-releasing_hormone GH-releasing_hormone|appos|END_ENTITY	Interaction of glucose and pyridostigmine on the secretion of growth_hormone -LRB- GH -RRB- induced by GH-releasing_hormone -LRB- GHRH -RRB- .
2498860	0	GH	90,92	GHRH	112,116	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|acl:relcl|responsiveness responsiveness|xcomp|END_ENTITY	Replenishment of brain catecholamine stores does not restore the impaired growth_hormone -LRB- GH -RRB- responsiveness to GHRH in aged rats .
2545765	0	GH	38,40	GHRH	88,92	GH	GHRH	2688	2691	Gene	Gene	response|appos|START_ENTITY response|nmod|hormone hormone|appos|END_ENTITY	Calcitonin suppresses growth_hormone -LRB- GH -RRB- response to growth_hormone-releasing hormone -LRB- GHRH -RRB- in man .
25613666	0	GH	173,175	GHRH	99,103	GH	GHRH	2688	2691	Gene	Gene	regulating|dobj|START_ENTITY anterior|advcl|regulating anterior|dobj|cells cells|nmod|response response|nmod|END_ENTITY	Alteration of the miRNA expression profile in male porcine anterior pituitary cells in response to GHRH and CST and analysis of the potential roles for miRNAs in regulating GH .
2574645	0	GH	47,49	GHRH	64,68	GH	GHRH	2688	2691	Gene	Gene	responses|appos|START_ENTITY variability|nmod|responses Reasons|nmod|variability Reasons|acl|END_ENTITY	Reasons for the variability in growth_hormone -LRB- GH -RRB- responses to GHRH challenge : the endogenous hypothalamic-somatotroph_rhythm -LRB- HSR -RRB- .
26059749	0	GH	56,58	GHRH	111,115	GH	GHRH	2688	2691	Gene	Gene	isoforms|nsubj|START_ENTITY isoforms|nmod|administration administration|compound|END_ENTITY	Unaltered ratio of circulating levels of growth_hormone / GH isoforms in adults with Prader-Willi_syndrome after GHRH plus arginine administration .
2883595	0	GH	122,124	GHRH	138,142	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	response|appos|START_ENTITY infusions|nmod|response infusions|xcomp|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2883595	0	GH	122,124	GHRH	72,76	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	response|appos|START_ENTITY infusions|nmod|response infusions|nsubj|Effect Effect|appos|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2911939	0	GH	16,18	GHRH	38,42	GH	GHRH	2688	2691	Gene	Gene	Growth_hormone|appos|START_ENTITY responsiveness|nsubj|Growth_hormone responsiveness|xcomp|END_ENTITY	Growth_hormone -LRB- GH -RRB- responsiveness to GHRH in normal adults is not affected by short-term gonadal blockade .
3104015	0	GH	20,22	GHRH	43,47	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|dep|hormone hormone|appos|END_ENTITY	The growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- - GH-somatomedin axis : evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II .
3107163	0	GH	7,9	GHRH	23,27	GH	GHRH	2688	2691	Gene	Gene	responses|nsubj|START_ENTITY responses|nmod|END_ENTITY	Plasma GH responses to GHRH and other provocative stimuli in idiopathic_GH_deficiency with or without abnormal_delivery .
3119651	0	GH	58,60	GHRH	218,222	GH	GHRH	2688	2691	Gene	Gene	growth_hormone|appos|START_ENTITY hypothalamic_dysfunction|nmod|growth_hormone Evaluation|nmod|hypothalamic_dysfunction Evaluation|dep|patients patients|acl|using using|advcl|END_ENTITY	Evaluation of hypothalamic_dysfunction in growth_hormone -LRB- GH -RRB- - deficient patients using single versus multiple doses of GH-releasing hormone -LRB- GHRH-44 -RRB- and evidence for diurnal variation in somatotroph responsiveness to GHRH in GH-deficient patients .
7593423	0	GH	27,29	GHRH	98,102	GH	GHRH	2688	2691	Gene	Gene	Absence|appos|START_ENTITY secretion|nsubj|Absence secretion|nmod|administration administration|nmod|hormone hormone|appos|END_ENTITY	Absence of growth_hormone -LRB- GH -RRB- secretion after the administration of either GH-releasing hormone -LRB- GHRH -RRB- , GH-releasing peptide -LRB- GHRP-6 -RRB- , or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection .
7729789	0	GH	8,10	GHRH	57,61	GH	GHRH	2688	2691	Gene	Gene	response|compound|START_ENTITY Blunted|dobj|response Blunted|advcl|growth_hormone-releasing_hormone growth_hormone-releasing_hormone|xcomp|END_ENTITY	Blunted GH response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- alone or combined with arginine in non-insulin-dependent_diabetes_mellitus .
7746092	0	GH	83,85	GHRH	125,129	GH	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Modulation of long-term memory and extinction responses induced by growth_hormone -LRB- GH -RRB- and growth_hormone_releasing_hormone -LRB- GHRH -RRB- in rats .
8349808	0	GH	31,33	GHRH	82,86	GH	GHRH	2688	2691	Gene	Gene	secretion|appos|START_ENTITY secretion|nmod|hormone hormone|appos|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- secretion by a selective GH-releasing hormone -LRB- GHRH -RRB- antagonist .
8349808	1	GH	172,174	GHRH	146,150	GH	GHRH	2688	2691	Gene	Gene	generation|nmod|START_ENTITY END_ENTITY|nmod|generation	Direct evidence for involvement of endogenous GHRH in the generation of GH pulses .
8421084	0	GH	116,118	GHRH	49,53	GH	GHRH	2688	2691	Gene	Gene	secretion|compound|START_ENTITY atropine|nmod|secretion hormone|appos|atropine hormone|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
8421084	0	GH	26,28	GHRH	49,53	GH	GHRH	2688	2691	Gene	Gene	growth_hormone|appos|START_ENTITY Effect|nmod|growth_hormone Effect|dep|hormone hormone|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
8513607	0	GH	79,81	GHRH	129,133	GH	GHRH	2688	2691	Gene	Gene	response|appos|START_ENTITY response|nmod|stimulation stimulation|appos|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
9024267	0	GH	31,33	GHRH	108,112	GH	GHRH	2688	2691	Gene	Gene	Suppression|appos|START_ENTITY hypersecretion|nsubj|Suppression hypersecretion|nmod|antagonist antagonist|compound|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
9024267	0	GH	31,33	GHRH	87,91	GH	GHRH	2688	2691	Gene	Gene	Suppression|appos|START_ENTITY hypersecretion|nsubj|Suppression hypersecretion|xcomp|due due|nmod|GH-releasing_hormone GH-releasing_hormone|appos|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
2863915	0	GH	23,25	GRF	101,104	GH	GRF	2688	2691	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Plasma growth_hormone -LRB- GH -RRB- and somatomedin_C response to continuous growth_hormone-releasing factor -LRB- GRF -RRB- infusion in patients with GH_deficiency .
12955026	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	2688	2688	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- status and body composition in normal ageing and in elderly adults with GH_deficiency .
1374019	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of gastric structure and function in the GH-deficient rat : up-regulation of intrinsic factor .
1385420	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- induction of tyrosine phosphorylation and activation of mitogen-activated_protein kinases in cells transfected with rat GH_receptor cDNA .
2082191	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of cytochrome P-450IIC12 , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , and GH_receptor messenger RNA expression in primary rat hepatocytes : a hormonal interplay with insulin , IGF-I , and thyroid hormone .
2491809	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing hormone by perifused pituitary cells from male , female , and testicular feminized rats .
3084533	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in children with subnormal integrated concentrations of GH .
3114296	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to a single intravenous injection of synthetic GH-releasing hormone in prepubertal children with growth_failure .
7093701	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- immunoreactivity in the rodent and primate CNS : distribution , characterization and presence posthypophysectomy .
8016152	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	binding|appos|START_ENTITY binding|compound|END_ENTITY	Growth_hormone -LRB- GH -RRB- binding and effects of GH analogs in transgenic_mice .
8185813	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of a rat serine_protease_inhibitor fusion gene in cells transfected with GH_receptor cDNA .
8374692	0	GH	68,70	Growth_hormone	0,14	GH	Growth hormone	2688	2688	Gene	Gene	use|nmod|START_ENTITY END_ENTITY|dep|use	Growth_hormone -LRB- GH -RRB- and adult bone remodeling : the potential use of GH in treatment of osteoporosis .
8459190	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	378781(Tax:9031)	378781(Tax:9031)	Gene	Gene	suppression|appos|START_ENTITY suppression|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- suppression of catecholamine turnover in the chicken hypothalamus : implications for GH autoregulation .
9186309	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing peptide-6 in patients with insulin-dependent_diabetes_mellitus .
9186816	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in short children : lack of correlation with endogenous nocturnal GH secretion .
9379123	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of submandibular gland structure and function in the GH-deficient rat : upregulation of haptocorrin .
9768681	0	GH	16,18	Growth_hormone	0,14	GH	Growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing peptide-6 in type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion .
17689128	0	GH	29,31	IGF-1	33,38	GH	IGF-1	2688	3479	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Serum ghrelin levels but not GH , IGF-1 and IGFBP-3 levels are altered in patients with fibromyalgia_syndrome .
25028982	0	GH	85,87	IGF-1	118,123	GH	IGF-1	2688	3479	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	The effect of maximal physical exercise on relationships between the growth_hormone -LRB- GH -RRB- and insulin_growth_factor_1 -LRB- IGF-1 -RRB- and transcriptional activity of CYP1A2 in young ice hockey players .
11249917	0	GH	32,34	IGF-I	70,75	GH	IGF-I	2688	3479	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Correlations of growth_hormone -LRB- GH -RRB- and insulin-like_growth_factor_I -LRB- IGF-I -RRB- : effects of exercise and abuse by athletes .
12110529	0	GH	28,30	IGF-I	14,19	GH	IGF-I	443329(Tax:9940)	443318(Tax:9940)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Regulation of IGF-I mRNA by GH : putative functions for class 1 and 2 message .
8612531	0	GH	87,89	IGF-I	64,69	GH	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Differential long-term effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- growth_hormone -LRB- GH -RRB- , and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats .
9657073	0	GH	14,16	IGFBP-3	73,80	GH	IGFBP-3	2688	3486	Gene	Gene	therapy|compound|START_ENTITY effect|nmod|therapy effect|nmod|END_ENTITY	The effect of GH therapy on the immunoreactive forms and distribution of IGFBP-3 , IGF-I , the acid-labile_subunit , and growth rate in GH-deficient children .
10853188	0	GH	41,43	Leptin	0,6	GH	Leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Leptin stimulates basal and GHRH-induced GH release from cultured rat anterior pituitary cells in vitro .
9724042	0	GH	71,73	Leptin	0,6	GH	Leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	secretion|appos|START_ENTITY stimulator|nmod|secretion stimulator|nsubj|END_ENTITY	Leptin is a potent stimulator of spontaneous pulsatile growth_hormone -LRB- GH -RRB- secretion and the GH response to GH-releasing_hormone .
25833299	0	GH	32,34	SOCS2	53,58	GH	SOCS2	14599(Tax:10090)	216233(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1 .
8536603	0	GH	39,41	Somatostatin	0,12	GH	Somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|appos|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	Somatostatin increases growth_hormone -LRB- GH -RRB- secretion in a subpopulation of porcine somatotropes : evidence for functional and morphological heterogeneity among porcine GH-producing cells .
3918278	0	GH	27,29	TRH	0,3	GH	TRH	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	TRH stimulation of in vivo GH release in the domestic fowl .
9657355	0	GH	24,26	angiotensin_II	38,52	GH	angiotensin II	2688	183	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Stimulation of ACTH and GH release by angiotensin_II in normal men is mediated by the AT1 receptor subtype .
2180981	0	GH	27,29	bone_Gla_protein	41,57	GH	bone Gla protein	2688	632	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on plasma bone_Gla_protein in GH-deficient adults .
2370291	0	GH	62,64	bone_Gla_protein	6,22	GH	bone Gla protein	2688	632	Gene	Gene	deficiency|appos|START_ENTITY marker|nmod|deficiency END_ENTITY|dep|marker	Serum bone_Gla_protein : a potential marker of growth_hormone -LRB- GH -RRB- deficiency and the response to GH therapy .
11344181	0	GH	106,108	gonadotropin-releasing_hormone	28,58	GH	gonadotropin-releasing hormone	2688	2796	Gene	Gene	growth_hormone|appos|START_ENTITY administering|nmod|growth_hormone administering|dobj|agonist agonist|amod|END_ENTITY	The effect of administering gonadotropin-releasing_hormone agonist with recombinant-human growth_hormone -LRB- GH -RRB- on the final height of girls with isolated_GH_deficiency : results from a controlled study .
12629103	0	GH	25,27	gonadotropin-releasing_hormone	83,113	GH	gonadotropin-releasing hormone	2688	2796	Gene	Gene	benefit|nsubj|START_ENTITY benefit|nmod|therapy therapy|nmod|analogs analogs|amod|END_ENTITY	Can some growth_hormone -LRB- GH -RRB- - deficient children benefit from combined therapy with gonadotropin-releasing_hormone analogs and GH ?
12955021	0	GH	100,102	gonadotropin-releasing_hormone	41,71	GH	gonadotropin-releasing hormone	2688	2796	Gene	Gene	treatment|appos|START_ENTITY experience|nmod|treatment experience|nmod|addition addition|nmod|agonists agonists|amod|END_ENTITY	The KIGS experience with the addition of gonadotropin-releasing_hormone agonists to growth_hormone -LRB- GH -RRB- treatment of children with idiopathic_GH_deficiency .
16787696	0	GH	103,105	gonadotropin-releasing_hormone	34,64	GH	gonadotropin-releasing hormone	2688	2796	Gene	Gene	treatment|appos|START_ENTITY agonists|nmod|treatment agonists|amod|END_ENTITY	A brief review of the addition of gonadotropin-releasing_hormone agonists -LRB- GnRH-Ag -RRB- to growth_hormone -LRB- GH -RRB- treatment of children with idiopathic growth_hormone deficiency : Previously published studies from America .
3143542	0	GH	236,238	gonadotropin-releasing_hormone	61,91	GH	gonadotropin-releasing hormone	2688	2796	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Endogenous human growth_hormone -LRB- GH -RRB- modulates the effect of gonadotropin-releasing_hormone on pituitary function and the gonadotropin response to the negative feedback effect of testosterone in adult male transgenic_mice bearing human GH gene .
3143542	0	GH	33,35	gonadotropin-releasing_hormone	61,91	GH	gonadotropin-releasing hormone	2688	2796	Gene	Gene	growth_hormone|appos|START_ENTITY modulates|nsubj|growth_hormone modulates|dobj|effect effect|nmod|gene gene|amod|END_ENTITY	Endogenous human growth_hormone -LRB- GH -RRB- modulates the effect of gonadotropin-releasing_hormone on pituitary function and the gonadotropin response to the negative feedback effect of testosterone in adult male transgenic_mice bearing human GH gene .
10084578	0	GH	34,36	growth_hormone	18,32	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Selective lack of growth_hormone -LRB- GH -RRB- response to the GH-releasing_peptide hexarelin in patients with GH-releasing hormone receptor deficiency .
10199767	0	GH	20,22	growth_hormone	4,18	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The growth_hormone -LRB- GH -RRB- response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH_deficiency .
10365112	0	GH	134,136	growth_hormone	118,132	GH	growth hormone	2688	2688	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Decreased serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - I in patients with lung_cancer : temporal relationship with growth_hormone -LRB- GH -RRB- levels .
10468950	0	GH	92,94	growth_hormone	76,90	GH	growth hormone	2688	2688	Gene	Gene	excretion|appos|START_ENTITY excretion|amod|END_ENTITY	The impact of gender , puberty and body mass on reference values for urinary growth_hormone -LRB- GH -RRB- excretion in normally growing non-obese and obese children .
10484056	0	GH	66,68	growth_hormone	50,64	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Elevated insulin levels contribute to the reduced growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in obese subjects .
10752072	0	GH	27,29	growth_hormone	11,25	GH	growth hormone	2688	2688	Gene	Gene	Control|appos|START_ENTITY Control|nmod|END_ENTITY	Control of growth_hormone -LRB- GH -RRB- release by GH secretagogues .
10753592	0	GH	45,47	growth_hormone	29,43	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Glucocorticoid regulation of growth_hormone -LRB- GH -RRB- secretagogue-induced growth responses and GH secretagogue receptor expression in the rat .
10770194	0	GH	68,70	growth_hormone	52,66	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effects of short-term glucocorticoid deprivation on growth_hormone -LRB- GH -RRB- response to GH-releasing peptide-6 : studies in normal men and in patients with adrenal_insufficiency .
10780945	0	GH	29,31	growth_hormone	13,27	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Induction of growth_hormone -LRB- GH -RRB- mRNA by pulsatile GH-releasing hormone in rats is pattern specific .
10794128	0	GH	30,32	growth_hormone	14,28	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- secretion by different glutamate receptor subtypes in the rat .
10830294	0	GH	28,30	growth_hormone	12,26	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	High plasma growth_hormone -LRB- GH -RRB- levels inhibit expression of GH secretagogue receptor messenger ribonucleic_acid levels in the rat pituitary .
11225641	0	GH	39,41	growth_hormone	23,37	GH	growth hormone	2688	2688	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	Unfavourable impact of growth_hormone -LRB- GH -RRB- discontinuation on body composition and cholesterol profiles after the completion of height growth in GH-deficient young adults .
11297586	0	GH	91,93	growth_hormone	75,89	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Relationship between the morphological evaluation of the pituitary and the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone Plus arginine in children and adults with congenital_hypopituitarism .
11916628	0	GH	36,38	growth_hormone	20,34	GH	growth hormone	2688	2688	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of different growth_hormone -LRB- GH -RRB- mutants on the regulation of GH-receptor gene transcription in a human hepatoma cell line .
12466380	0	GH	62,64	growth_hormone	46,60	GH	growth hormone	2688	2688	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Impact of experimental blockade of peripheral growth_hormone -LRB- GH -RRB- receptors on the kinetics of endogenous and exogenous GH removal in healthy women and men .
12519835	0	GH	26,28	growth_hormone	10,24	GH	growth hormone	2688	2688	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- and/or testosterone replacement on the prostate in GH-deficient adult patients .
12608936	0	GH	30,32	growth_hormone	14,28	GH	growth hormone	2688	2688	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of growth_hormone -LRB- GH -RRB- replacement therapy in adult patients with type_1_diabetes_mellitus and GH_deficiency .
12679475	0	GH	26,28	growth_hormone	10,24	GH	growth hormone	2688	2688	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on glycerol and free fatty_acid metabolism during exhaustive exercise in GH-deficient adults .
12840904	0	GH	29,31	growth_hormone	13,27	GH	growth hormone	2688	2688	Gene	Gene	effect|appos|START_ENTITY END_ENTITY|dobj|effect	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
12957475	0	GH	98,100	growth_hormone	82,96	GH	growth hormone	100305005(Tax:7998)	100305005(Tax:7998)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Development of an enzyme-linked immunosorbent assay for the measurement of plasma growth_hormone -LRB- GH -RRB- levels in channel_catfish -LRB- Ictalurus_punctatus -RRB- : assessment of environmental salinity and GH secretogogues on plasma GH levels .
1400881	0	GH	22,24	growth_hormone	6,20	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Acute growth_hormone -LRB- GH -RRB- response to GH-releasing hexapeptide in humans is independent of endogenous GH-releasing hormone .
1454656	0	GH	31,33	growth_hormone	15,29	GH	growth hormone	2688	2688	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
14557454	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	2688	2688	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Sexual dimorphism of growth_hormone -LRB- GH -RRB- regulation in humans : endogenous GH-releasing hormone maintains basal GH in women but not in men .
14602749	0	GH	27,29	growth_hormone	11,25	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on ghrelin , leptin , and adiponectin in GH-deficient patients .
14751587	0	GH	39,41	growth_hormone	23,37	GH	growth hormone	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Age-related changes in growth_hormone -LRB- GH -RRB- cells in the pituitary gland of male mice are mediated by GH-releasing hormone but not by somatostatin in the hypothalamus .
1517388	0	GH	43,45	growth_hormone	27,41	GH	growth hormone	2688	2688	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations in spontaneous growth_hormone -LRB- GH -RRB- secretion and the response to GH-releasing hormone in children with nonorganic nutritional_dwarfing .
15242989	0	GH	24,26	growth_hormone	8,22	GH	growth hormone	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of growth_hormone -LRB- GH -RRB- in liver_regeneration .
15305235	0	GH	43,45	growth_hormone	27,41	GH	growth hormone	2688	2688	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Age-related differences in growth_hormone -LRB- GH -RRB- regulation during strenuous exercise .
15464751	0	GH	39,41	growth_hormone	23,37	GH	growth hormone	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Age-related changes in growth_hormone -LRB- GH -RRB- - releasing hormone and somatostatin neurons in the hypothalamus and in GH cells in the anterior pituitary of female mice .
15472470	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	102171600	102171600	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- pulses in the peripheral circulation and GH-releasing_hormone and somatostatin profiles in the cerebrospinal fluid of goats .
15486811	0	GH	27,29	growth_hormone	11,25	GH	growth hormone	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on mRNA levels of uncoupling proteins 1 , 2 , and 3 in brown and white_adipose_tissues and skeletal muscle in obese mice .
15504394	0	GH	32,34	growth_hormone	11,25	GH	growth hormone	378781(Tax:9031)	378781(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Testicular growth_hormone -LRB- GH -RRB- : GH expression in spermatogonia and primary spermatocytes .
15531488	0	GH	44,46	growth_hormone	28,42	GH	growth hormone	2688	2688	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant human growth_hormone -LRB- GH -RRB- replacement on the hypothalamic-pituitary-adrenal_axis in adult GH-deficient patients .
15629012	0	GH	55,57	growth_hormone	39,53	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The level of physical activity and the growth_hormone -LRB- GH -RRB- response to acute physical exercise .
1576976	0	GH	64,66	growth_hormone	48,62	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The relationship between beta-endorphin and the growth_hormone -LRB- GH -RRB- response to GH releasing hormone in prepubertal children .
1576976	0	GH	80,82	growth_hormone	48,62	GH	growth hormone	2688	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The relationship between beta-endorphin and the growth_hormone -LRB- GH -RRB- response to GH releasing hormone in prepubertal children .
15879358	0	GH	34,36	growth_hormone	85,99	GH	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Seasonality of growth response to GH therapy in prepubertal children with idiopathic growth_hormone deficiency .
1592867	0	GH	47,49	growth_hormone	31,45	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Influence of pyridostigmine on growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone pre - and postprandially in normal and obese subjects .
1592874	0	GH	40,42	growth_hormone	24,38	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Arginine normalizes the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in adult patients receiving chronic daily immunosuppressive glucocorticoid therapy .
1592893	0	GH	81,83	growth_hormone	65,79	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Sleep , awakenings , and insulin-like_growth_factor-I modulate the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing_hormone .
16059977	0	GH	46,48	growth_hormone	30,44	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of recombinant human growth_hormone -LRB- GH -RRB- replacement therapy on bone metabolism in children with GH_deficiency -RSB- .
16444180	0	GH	26,28	growth_hormone	10,24	GH	growth hormone	2688	2688	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on the immune system .
1671784	0	GH	58,60	growth_hormone	42,56	GH	growth hormone	2688	2688	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Reliability of stimulated and spontaneous growth_hormone -LRB- GH -RRB- levels for identifying the child with low GH secretion .
1714828	0	GH	45,47	growth_hormone	29,43	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of growth_hormone -LRB- GH -RRB- receptor messenger ribonucleic acid -LRB- mRNA -RRB- in rat adipose tissue , adipocytes , and adipocyte precursor cells : GH regulation of GH_receptor mRNA .
17381489	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	2688	2688	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Long-term effects of growth_hormone -LRB- GH -RRB- on bone mineral status and bone turnover markers in patients with isolated_GH_deficiency and multiple_pituitary_hormone_deficiency .
17456794	0	GH	28,30	growth_hormone	12,26	GH	growth hormone	2688	2688	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Role of the growth_hormone -LRB- GH -RRB- receptor transmembrane domain in receptor predimerization and GH-induced activation .
18029459	0	GH	29,31	growth_hormone	13,27	GH	growth hormone	2688	2688	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of growth_hormone -LRB- GH -RRB- receptor deletion of exon 3 and full-length isoforms on GH response and final height in patients with severe GH_deficiency .
18765508	0	GH	52,54	growth_hormone	36,50	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The effects of central adiposity on growth_hormone -LRB- GH -RRB- response to GH-releasing hormone-arginine stimulation testing in men .
18777498	0	GH	45,47	growth_hormone	29,43	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of one-year low-dose growth_hormone -LRB- GH -RRB- therapy on body composition , lipid profile and carbohydrate metabolism in young adults with childhood-onset severe GH_deficiency confirmed after completion of growth promotion .
1879666	0	GH	161,163	growth_hormone	52,66	GH	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution and characterization of immunoreactive growth_hormone -LRB- GH -RRB- in the pituitary of the frog Rana ridibunda using an antiserum against purified bullfrog GH .
1879666	0	GH	68,70	growth_hormone	52,66	GH	growth hormone	2688	2688	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and characterization of immunoreactive growth_hormone -LRB- GH -RRB- in the pituitary of the frog Rana ridibunda using an antiserum against purified bullfrog GH .
1955500	0	GH	74,76	growth_hormone	58,72	GH	growth hormone	2688	2688	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Dexamethasone treatment in man induces changes in 24-hour growth_hormone -LRB- GH -RRB- secretion profile without altering total GH released .
1977761	0	GH	56,58	growth_hormone	40,54	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Alpha 2-adrenergic agonism enhances the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone through an inhibition of hypothalamic somatostatin release in normal men .
20061428	0	GH	105,107	growth_hormone	89,103	GH	growth hormone	2688	2688	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth_hormone -LRB- GH -RRB- - treated children with Prader-Willi_syndrome and in non-GH-treated obese children .
20146168	0	GH	26,28	growth_hormone	10,24	GH	growth hormone	2688	2688	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on fasting and postprandial metabolism in GH_deficiency .
20529604	0	GH	112,114	growth_hormone	96,110	GH	growth hormone	2688	2688	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Observation of children with total or partial somatotropic pituitary_hypofunction treated with growth_hormone -LRB- GH -RRB- -RSB- .
21073120	0	GH	59,61	growth_hormone	43,57	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	GHR and VDR genes do not contribute to the growth_hormone -LRB- GH -RRB- response in GH deficient_and_Turner_syndrome patients .
2143200	0	GH	131,133	growth_hormone	10,24	GH	growth hormone	2688	2688	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Perinatal growth_hormone -LRB- GH -RRB- physiology : effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH .
21637543	0	GH	81,83	growth_hormone	65,79	GH	growth hormone	102171600	102171600	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association of two single nucleotide polymorphisms -LRB- SNPs -RRB- in growth_hormone -LRB- GH -RRB- gene with litter size and superovulation response in goat-breeds .
2180981	0	GH	27,29	growth_hormone	11,25	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on plasma bone_Gla_protein in GH-deficient adults .
22120536	0	GH	79,81	growth_hormone	63,77	GH	growth hormone	103387754	103387754	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure , polymorphism and expression analysis of the growth_hormone -LRB- GH -RRB- gene in female and male Half-smooth_tongue_sole -LRB- Cynoglossus_semilaevis -RRB- .
2226343	0	GH	30,32	growth_hormone	14,28	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Change in the growth_hormone -LRB- GH -RRB- response to GH-releasing_factor -LRB- GRF -RRB- caused by exogenous GH in short children .
2258583	0	GH	62,64	growth_hormone	46,60	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of acipimox , a lipid lowering drug , on growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal subjects .
2284886	0	GH	52,54	growth_hormone	36,50	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effects of methimazole treatment on growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in patients with hyperthyroidism .
23262274	0	GH	44,46	growth_hormone	28,42	GH	growth hormone	378781(Tax:9031)	378781(Tax:9031)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Neuro-protective effects of growth_hormone -LRB- GH -RRB- after hypoxia-ischemia injury in embryonic chicken cerebellum .
2387255	0	GH	30,32	growth_hormone	14,28	GH	growth hormone	2688	2688	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- bioactivity by a recombinant human GH-binding_protein .
23970781	0	GH	107,109	growth_hormone	35,49	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of zinc binding residues in growth_hormone -LRB- GH -RRB- and altered intracellular zinc content on regulated GH secretion .
2415346	0	GH	27,29	growth_hormone	11,25	GH	growth hormone	2688	2688	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of growth_hormone -LRB- GH -RRB- from purified somatotrophs : interaction of GH-releasing factor and somatostatin and role of adenosine_3 ' ,5 ' - monophosphate .
2491803	2	GH	127,129	growth_hormone	111,125	GH	growth hormone	443329(Tax:9940)	443329(Tax:9940)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of age , breeding season , and twinning on the growth_hormone -LRB- GH -RRB- response to GH-releasing factor : evidence for a homeostatic role of fetal GH .
2492921	0	GH	40,42	growth_hormone	24,38	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of pulsatile growth_hormone -LRB- GH -RRB- secretion and somatic growth in immature rats with a synthetic GH-releasing factor antagonist .
2506218	0	GH	99,101	growth_hormone	83,97	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Repetitive growth_hormone-releasing_hormone administration restores the attenuated growth_hormone -LRB- GH -RRB- response to GH-releasing hormone testing in normal aging .
2545765	0	GH	38,40	growth_hormone	22,36	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Calcitonin suppresses growth_hormone -LRB- GH -RRB- response to growth_hormone-releasing hormone -LRB- GHRH -RRB- in man .
2562828	0	GH	30,32	growth_hormone	14,28	GH	growth hormone	2688	2688	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- secretion by GH-releasing factor , somatostatin , and insulin-like_growth_factor_I in ovine fetal and neonatal pituitary cells in vitro .
2563681	2	GH	105,107	growth_hormone	89,103	GH	growth hormone	443329(Tax:9940)	443329(Tax:9940)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The effect of somatostatin on the growth_hormone -LRB- GH -RRB- response to GH-releasing factor .
2565914	0	GH	34,36	growth_hormone	18,32	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Inhibition of the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone by constant Met-GH infusions .
2566942	0	GH	129,131	growth_hormone	113,127	GH	growth hormone	2688	2688	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2570721	0	GH	48,50	growth_hormone	32,46	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Ultrastructural distribution of growth_hormone -LRB- GH -RRB- mRNA and GH intron I sequences in rat pituitary gland : effects of GH releasing factor and somatostatin .
2591065	0	GH	42,44	growth_hormone	26,40	GH	growth hormone	2688	2688	Gene	Gene	excretion|appos|START_ENTITY excretion|amod|END_ENTITY	Quantification of urinary growth_hormone -LRB- GH -RRB- excretion by centrifugal ultrafiltration and radioimmunoassay : appraisal of the relationship between 24 h urinary GH and mean 24 h serum GH levels in normal and abnormal states of GH secretion .
26511947	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	2688	2688	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Long-term effects of growth_hormone -LRB- GH -RRB- replacement therapy on hematopoiesis in a large cohort of children with GH_deficiency .
2809099	0	GH	27,29	growth_hormone	11,25	GH	growth hormone	2688	2688	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in growth_hormone -LRB- GH -RRB- secretion and in growth during puberty .
2881773	0	GH	49,51	growth_hormone	33,47	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	suppression|appos|START_ENTITY suppression|amod|END_ENTITY	Mechanisms of calcitonin-induced growth_hormone -LRB- GH -RRB- suppression : roles of somatostatin_and_GH-releasing_factor .
2883595	0	GH	122,124	growth_hormone	106,120	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2901338	0	GH	91,93	growth_hormone	75,89	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Delayed release formulation of the somatostatin analog RC-160 inhibits the growth_hormone -LRB- GH -RRB- response to GH-releasing factor - -LRB- 1-29 -RRB- NH2 and decreases elevated prolactin levels in rats .
2906083	0	GH	39,41	growth_hormone	23,37	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	The rebound release of growth_hormone -LRB- GH -RRB- following somatostatin infusion in rats involves hypothalamic GH-releasing_factor release .
3000727	0	GH	29,31	growth_hormone	13,27	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of growth_hormone -LRB- GH -RRB- receptors in adipocytes of hypophysectomized rats by GH .
3075099	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	2688	2688	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Modulating effect of growth_hormone -LRB- GH -RRB- on PHA-induced lymphocyte proliferation .
3079770	0	GH	25,27	growth_hormone	9,23	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Impaired growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in thalassemia major .
3082919	0	GH	35,37	growth_hormone	19,33	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Suppression of the growth_hormone -LRB- GH -RRB- response to clonidine and GH-releasing hormone by exogenous GH .
3085872	0	GH	85,87	growth_hormone	69,83	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Effects of neonatal administration of monosodium_glutamate on plasma growth_hormone -LRB- GH -RRB- response to GH-releasing_factor in adult male and female rats .
3091629	0	GH	106,108	growth_hormone	90,104	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The effect of pulsatile administration , continuous infusion , and diurnal variation on the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal men .
3100282	0	GH	42,44	growth_hormone	26,40	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of estrogen on the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing factor in the castrate adult female rat in vivo .
3126213	0	GH	71,73	growth_hormone	33,47	GH	growth hormone	2688	2688	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|administration administration|compound|END_ENTITY	The effects of acute and chronic growth_hormone -LRB- GH -RRB- administration on GH secretion in patients with idiopathic_GH_deficiency .
3127419	0	GH	82,84	growth_hormone	66,80	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Differential effects of feeding on the ultradian variation of the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal subjects and patients with obesity and anorexia_nervosa .
3135487	0	GH	39,41	growth_hormone	23,37	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Feedback regulation of growth_hormone -LRB- GH -RRB- - releasing hormone gene expression by GH in rat hypothalamus .
3141549	0	GH	58,60	growth_hormone	42,56	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Phorbol_ester pretreatment attenuates the growth_hormone -LRB- GH -RRB- response to GH-releasing_factor in cultured rat pituitary cells .
3142918	0	GH	44,46	growth_hormone	28,42	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Inhibition by prednisone of growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal men .
3425315	0	GH	63,65	growth_hormone	47,61	GH	growth hormone	2688	2688	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A longitudinal study on growth and spontaneous growth_hormone -LRB- GH -RRB- secretion in children with irradiated brain_tumors .
3654910	0	GH	132,134	growth_hormone	26,40	GH	growth hormone	2688	2688	Gene	Gene	elevation|nmod|START_ENTITY END_ENTITY|nmod|elevation	Characterization of serum growth_hormone -LRB- GH -RRB- and insulin-like_growth_factor_I in active acromegaly with minimal elevation of serum GH .
3926807	0	GH	24,26	growth_hormone	8,22	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Blunted growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in hypothyroidism resolves in the euthyroid state .
7525625	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	2688	2688	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of human growth_hormone -LRB- GH -RRB- administration in GH-deficient adults : a 20-day metabolic ward study .
7629249	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Acipimox potentiates growth_hormone -LRB- GH -RRB- response to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty_acid in normal and obese subjects .
7681769	0	GH	41,43	growth_hormone	25,39	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of galanin on the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in patients with Cushing 's _ disease .
7714096	0	GH	30,32	growth_hormone	14,28	GH	growth hormone	2688	2688	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Screening for growth_hormone -LRB- GH -RRB- gene splice-site mutations in sporadic cases with severe isolated_GH_deficiency using ectopic transcript analysis .
7829600	0	GH	167,169	growth_hormone	29,43	GH	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of recombinant human growth_hormone -LRB- GH -RRB- on bone and intermediary metabolism in patients receiving chronic glucocorticoid treatment with suppressed endogenous GH response to GH-releasing hormone .
7829600	0	GH	45,47	growth_hormone	29,43	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human growth_hormone -LRB- GH -RRB- on bone and intermediary metabolism in patients receiving chronic glucocorticoid treatment with suppressed endogenous GH response to GH-releasing hormone .
7835299	0	GH	27,29	growth_hormone	11,25	GH	growth hormone	2688	2688	Gene	Gene	Control|appos|START_ENTITY Control|nmod|END_ENTITY	Control of growth_hormone -LRB- GH -RRB- binding protein release from human hepatoma cells expressing full-length GH_receptor .
7901787	0	GH	42,44	growth_hormone	26,40	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
7903312	0	GH	72,74	growth_hormone	56,70	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Somatostatin receptors , adenylate cyclase activity , and growth_hormone -LRB- GH -RRB- response to octreotide in GH-secreting adenomas .
7907904	0	GH	55,57	growth_hormone	39,53	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Different effects of pyridostigmine on growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in endogenous and exogenous hypercortisolemic patients .
8263146	0	GH	48,50	growth_hormone	32,46	GH	growth hormone	2688	2688	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Marked effects of sustained low growth_hormone -LRB- GH -RRB- levels on day-to-day fuel metabolism : studies in GH-deficient patients and healthy untreated subjects .
8513607	0	GH	79,81	growth_hormone	63,77	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
8606641	0	GH	67,69	growth_hormone	51,65	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effects of acipimox , an antilipolytic drug , on the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone alone or combined with arginine in obesity .
8626871	0	GH	32,34	growth_hormone	16,30	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The decrease in growth_hormone -LRB- GH -RRB- response after repeated stimulation with GH-releasing hormone is partly caused by an elevation of somatostatin tonus .
8628114	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of galanin on growth_hormone -LRB- GH -RRB- response to thyrotropin releasing hormone of rat pituitary GH-secreting adenomatous cells -LRB- GH1 -RRB- in culture .
8636340	0	GH	45,47	growth_hormone	29,43	GH	growth hormone	2688	2688	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Dose-dependent inhibition of growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH release by corticotropin-releasing_hormone in prepubertal children .
8654647	0	GH	49,51	growth_hormone	33,47	GH	growth hormone	2688	2688	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Gonadal function and response to growth_hormone -LRB- GH -RRB- in boys with isolated_GH_deficiency and to GH and gonadotropins in boys with multiple_pituitary_hormone_deficiencies .
8768878	0	GH	40,42	growth_hormone	24,38	GH	growth hormone	2688	2688	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of long-term growth_hormone -LRB- GH -RRB- treatment on bone_mineral_density in children with GH_deficiency .
8816035	0	GH	35,37	growth_hormone	19,33	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
8905475	0	GH	39,41	growth_hormone	23,37	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant growth_hormone -LRB- GH -RRB- treatment on bone_mineral_density and body composition in adults with childhood onset growth_hormone_deficiency .
8923850	0	GH	31,33	growth_hormone	15,29	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Restoration of growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in elderly and obese subjects by acute pharmacological reduction of plasma free fatty_acids .
8985666	0	GH	58,60	growth_hormone	42,56	GH	growth hormone	443329(Tax:9940)	443329(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The effects of a duplication in the ovine growth_hormone -LRB- GH -RRB- gene on GH expression in the pituitaries of ram lambs from lean and fat-selected sheep lines .
9078817	0	GH	84,86	growth_hormone	68,82	GH	growth hormone	2688	2688	Gene	Gene	screening|appos|START_ENTITY screening|nmod|diagnosis diagnosis|nmod|_ _|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- screening for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency .
9100588	0	GH	53,55	growth_hormone	37,51	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of obesity and feeding on the growth_hormone -LRB- GH -RRB- response to the GH secretagogue L-692 ,429 in young men .
9112397	0	GH	33,35	growth_hormone	17,31	GH	growth hormone	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Liver and kidney growth_hormone -LRB- GH -RRB- receptors are regulated differently in diabetic_GH and GH_antagonist transgenic_mice .
9125486	0	GH	73,75	growth_hormone	46,60	GH	growth hormone	2688	2688	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Effect of chronic treatment with biosynthetic growth_hormone -LRB- GH -RRB- on the GH response to double GH-releasing_hormone administration in children with short_stature .
9140905	0	GH	48,50	growth_hormone	32,46	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Exercise training decreases the growth_hormone -LRB- GH -RRB- response to acute constant-load exercise .
9144201	0	GH	107,109	growth_hormone	11,25	GH	growth hormone	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Functional growth_hormone -LRB- GH -RRB- receptors and GH are expressed by preimplantation mouse embryos : a role for GH in early embryogenesis ?
9177389	0	GH	30,32	growth_hormone	14,28	GH	growth hormone	2688	2688	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of growth_hormone -LRB- GH -RRB- on histomorphometric indices of bone_structure_and_bone_turnover in GH-deficient men .
9215300	0	GH	92,94	growth_hormone	76,90	GH	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Evidence for an inhibitory effect of physiological levels of insulin on the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in healthy subjects .
9302388	0	GH	37,39	growth_hormone	21,35	GH	growth hormone	2688	2688	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- status , serum leptin and body composition in healthy and GH_deficient elderly subjects .
9348244	0	GH	41,43	growth_hormone	25,39	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Quantitative analysis of growth_hormone -LRB- GH -RRB- pre-mRNA expression in cultured rat anterior pituitary cells by an intron-specific and competitive PCR method .
9745423	0	GH	41,43	growth_hormone	25,39	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of physiological growth_hormone -LRB- GH -RRB- therapy on cognition and quality of life in patients with adult-onset GH_deficiency .
9892845	0	GH	24,26	growth_hormone	8,22	GH	growth hormone	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of growth_hormone -LRB- GH -RRB- - releasing hormone and somatostatin on leptin-induced GH secretion .
9920068	0	GH	52,54	growth_hormone	36,50	GH	growth hormone	2688	2688	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of 20-kilodalton human growth_hormone -LRB- GH -RRB- are parallel those of 22-kilodalton human GH in normal and short children .
9920097	0	GH	92,94	growth_hormone	76,90	GH	growth hormone	2688	2688	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human insulin-like_growth_factor_I administration on growth_hormone -LRB- GH -RRB- secretion , both spontaneous and stimulated by GH-releasing hormone or hexarelin , a peptidyl GH secretagogue , in humans .
3928732	0	GH	85,87	growth_hormone-releasing_factor	15,46	GH	growth hormone-releasing factor	2688	2691	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of growth_hormone-releasing_factor -LRB- GRF -RRB- and dopamine on growth_hormone -LRB- GH -RRB- secretion in acromegaly .
16862465	0	GH	186,188	insulin-like_growth_factor_I	29,57	GH	insulin-like growth factor I	2688	3479	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Pregnancy-induced changes in insulin-like_growth_factor_I -LRB- IGF-I -RRB- , insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- , and acid-labile_subunit -LRB- ALS -RRB- in patients with growth_hormone _ -LRB- GH -RRB- _ deficiency and excess .
11900968	0	GH	102,104	leptin	52,58	GH	leptin	443329(Tax:9940)	443534(Tax:9940)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intravenous infusion of recombinant ovine leptin on feed intake and serum concentrations of GH , LH , insulin , IGF-1 , cortisol , and thyroxine in growing prepubertal ewe lambs .
9302388	0	GH	37,39	leptin	55,61	GH	leptin	2688	3952	Gene	Gene	status|appos|START_ENTITY status|appos|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- status , serum leptin and body composition in healthy and GH_deficient elderly subjects .
9678531	0	GH	128,130	leptin	58,64	GH	leptin	2688	3952	Gene	Gene	administration|compound|START_ENTITY modes|nmod|administration impact|nmod|modes lack|nmod|impact levels|dep|lack levels|nmod|END_ENTITY	Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients : lack of impact of different modes of GH administration .
9768649	0	GH	26,28	leptin	57,63	GH	leptin	2688	3952	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on serum concentrations of leptin : study in patients with acromegaly and GH_deficiency .
9867083	0	GH	108,110	leptin	6,12	GH	leptin	2688	3952	Gene	Gene	treatment|compound|START_ENTITY influence|nmod|treatment levels|dep|influence levels|compound|END_ENTITY	Serum leptin levels and leptin expression in growth_hormone -LRB- GH -RRB- - deficient and healthy adults : influence of GH treatment , gender , and fasting .
9867083	0	GH	61,63	leptin	24,30	GH	leptin	2688	3952	Gene	Gene	growth_hormone|appos|START_ENTITY expression|nmod|growth_hormone expression|compound|END_ENTITY	Serum leptin levels and leptin expression in growth_hormone -LRB- GH -RRB- - deficient and healthy adults : influence of GH treatment , gender , and fasting .
1973420	0	GH	100,102	somatostatin	31,43	GH	somatostatin	2688	6750	Gene	Gene	secretion|compound|START_ENTITY stimulation|nmod|secretion releasing|dobj|stimulation effects|parataxis|releasing effects|nmod|END_ENTITY	Impaired inhibitory effects of somatostatin on growth_hormone -LRB- GH -RRB- - releasing hormone stimulation of GH secretion after short term infusion .
1973420	0	GH	63,65	somatostatin	31,43	GH	somatostatin	2688	6750	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Impaired inhibitory effects of somatostatin on growth_hormone -LRB- GH -RRB- - releasing hormone stimulation of GH secretion after short term infusion .
2566942	0	GH	129,131	somatostatin	241,253	GH	somatostatin	2688	6750	Gene	Gene	effect|appos|START_ENTITY effect|acl|releasing releasing|nmod|man man|appos|act act|nmod|release release|nmod|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2566942	0	GH	159,161	somatostatin	241,253	GH	somatostatin	2688	6750	Gene	Gene	secretion|compound|START_ENTITY releasing|dobj|secretion releasing|nmod|man man|appos|act act|nmod|release release|nmod|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2906083	0	GH	39,41	somatostatin	53,65	GH	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|infusion infusion|compound|END_ENTITY	The rebound release of growth_hormone -LRB- GH -RRB- following somatostatin infusion in rats involves hypothalamic GH-releasing_factor release .
2908268	0	GH	77,79	somatostatin	137,149	GH	somatostatin	2688	6750	Gene	Gene	growth_hormone|dep|START_ENTITY expression|amod|growth_hormone studies|nmod|expression studies|dep|effects effects|nmod|factor factor|compound|END_ENTITY	Quantitative in-situ hybridization histochemistry studies on growth_hormone -LRB- GH -RRB- gene expression in acromegalic somatotrophs : effects of somatostatin , GH-releasing factor and cortisol .
6146235	0	GH	37,39	somatostatin	107,119	GH	somatostatin	2688	6750	Gene	Gene	growth_hormone|appos|START_ENTITY Inhibition|nmod|growth_hormone secretion|nsubj|Inhibition secretion|nmod|administration administration|nmod|END_ENTITY	Inhibition of foetal growth_hormone -LRB- GH -RRB- and thyrotrophin -LRB- TSH -RRB- secretion after maternal administration of somatostatin .
667280	0	GH	67,69	somatostatin	10,22	GH	somatostatin	2688	6750	Gene	Gene	secretion|appos|START_ENTITY Action|nmod|secretion Action|nmod|END_ENTITY	Action of somatostatin , levodopa and pyridoxine on growth_hormone -LRB- GH -RRB- secretion in newborn infants .
7901787	0	GH	42,44	somatostatin	193,205	GH	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	response|appos|START_ENTITY potentiates|dobj|response potentiates|parataxis|evidence evidence|nmod|control control|nmod|release release|nmod|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
14551231	0	GH	51,53	thyrotropin-releasing_hormone	91,120	GH	thyrotropin-releasing hormone	100356068(Tax:9986)	100346454(Tax:9986)	Gene	Gene	growth_hormone|appos|START_ENTITY effects|nmod|growth_hormone effects|amod|END_ENTITY	Endocrine and metabolic effects of growth_hormone -LRB- GH -RRB- compared with GH-releasing peptide , thyrotropin-releasing_hormone , and insulin infusion in a rabbit model of prolonged critical_illness .
1624675	0	GH	23,25	thyrotropin-releasing_hormone	182,211	GH	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|appos|START_ENTITY growth_hormone|dobj|responses growth_hormone|advcl|corticotropin-releasing_hormone corticotropin-releasing_hormone|nmod|END_ENTITY	Plasma growth_hormone -LRB- GH -RRB- responses to corticotropin-releasing_hormone in patients with acromegaly -- the effect of dexamethasone pretreatment and the comparison with GH responses to thyrotropin-releasing_hormone , gonadotropin-releasing_hormone and GH-releasing_hormone .
2512341	0	GH	44,46	thyrotropin-releasing_hormone	51,80	GH	thyrotropin-releasing hormone	2688	7200	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|acl|END_ENTITY	The paradoxical response of growth_hormone -LRB- GH -RRB- to thyrotropin-releasing_hormone -LRB- TRH -RRB- in constitutionally tall children involves a cholinergic pathway .
3108068	0	GH	160,162	thyrotropin-releasing_hormone	93,122	GH	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	secretion|appos|START_ENTITY stimulation|nmod|secretion stimulation|amod|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
3917270	0	GH	27,29	thyrotropin-releasing_hormone	126,155	GH	thyrotropin-releasing hormone	2688	7200	Gene	Gene	secretion|appos|START_ENTITY Changes|nmod|secretion Changes|dep|comparison comparison|nmod|END_ENTITY	Changes in growth_hormone -LRB- GH -RRB- secretion induced by human pancreatic GH releasing hormone-44 in acromegaly : a comparison with thyrotropin-releasing_hormone and bromocriptine .
3923021	0	GH	162,164	thyrotropin-releasing_hormone	82,111	GH	thyrotropin-releasing hormone	2688	7200	Gene	Gene	growth_hormone|appos|START_ENTITY patients|nmod|growth_hormone END_ENTITY|nmod|patients	Different responses of growth_hormone secretion to guanfacine , bromocriptine , and thyrotropin-releasing_hormone in acromegalic patients with pure growth_hormone -LRB- GH -RRB- - containing and mixed GH/prolactin-containing pituitary_adenomas .
7991070	0	GH	140,142	thyrotropin-releasing_hormone	205,234	GH	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|appos|START_ENTITY mechanism|nmod|responses involvement|nmod|mechanism Lack|nmod|involvement Lack|dep|comparison comparison|nmod|responses responses|nmod|END_ENTITY	Lack of involvement of the cholinergic mechanism in vasoactive intestinal peptide - and peptide-histidine_methionine-induced growth_hormone -LRB- GH -RRB- responses in acromegaly : comparison with the GH responses to thyrotropin-releasing_hormone and GH-releasing_hormone .
7991070	0	GH	189,191	thyrotropin-releasing_hormone	205,234	GH	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Lack of involvement of the cholinergic mechanism in vasoactive intestinal peptide - and peptide-histidine_methionine-induced growth_hormone -LRB- GH -RRB- responses in acromegaly : comparison with the GH responses to thyrotropin-releasing_hormone and GH-releasing_hormone .
8325956	0	GH-BP	32,37	Growth_hormone-binding_protein	0,30	GH-BP	Growth hormone-binding protein	2690	2690	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Growth_hormone-binding_protein -LRB- GH-BP -RRB- levels in follicular fluid from human preovulatory follicles : correlation with serum GH-BP levels .
24725418	0	GH-R	37,41	growth_hormone_receptor	12,35	GH-R	growth hormone receptor	100860790	100860790	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Presence of growth_hormone_receptor -LRB- GH-R -RRB- mRNA and protein in goat ovarian follicles and improvement of in vitro preantral follicle survival and development with GH .
4570040	0	GH-RF	56,61	growth_hormone_releasing_factor	23,54	GH-RF	growth hormone releasing factor	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Enzymatic synthesis of growth_hormone_releasing_factor -LRB- GH-RF -RRB- by rat incubates and by extracts of rat and porcine hypothalamic tissue .
14746863	0	GH-RH	49,54	growth_hormone-releasing_hormone	15,47	GH-RH	growth hormone-releasing hormone	2691	2691	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Antagonists of growth_hormone-releasing_hormone -LRB- GH-RH -RRB- enhance tumour growth inhibition induced by androgen deprivation in human MDA-Pca-2b prostate_cancers .
3089538	0	GH-RH	63,68	growth_hormone-releasing_hormone	29,61	GH-RH	growth hormone-releasing hormone	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	The hypothalamo-infundibular growth_hormone-releasing_hormone -LRB- GH-RH -RRB- system of the rat .
2040861	0	GH-receptor	76,87	GH	69,71	GH-receptor	GH	408184(Tax:9031)	378781(Tax:9031)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of hypophysectomy and acute administration of growth_hormone -LRB- GH -RRB- on GH-receptor binding in chick liver membranes .
2040861	0	GH-receptor	76,87	growth_hormone	53,67	GH-receptor	growth hormone	408184(Tax:9031)	378781(Tax:9031)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|administration administration|nmod|END_ENTITY	Effect of hypophysectomy and acute administration of growth_hormone -LRB- GH -RRB- on GH-receptor binding in chick liver membranes .
2226343	0	GH-releasing_factor	46,65	GRF	67,70	GH-releasing factor	GRF	2691	2691	Gene	Gene	Change|nmod|START_ENTITY Change|appos|END_ENTITY	Change in the growth_hormone -LRB- GH -RRB- response to GH-releasing_factor -LRB- GRF -RRB- caused by exogenous GH in short children .
1759034	0	GH-releasing_factor	15,34	TSH_response_to_TSH-releasing_factor	69,105	GH-releasing factor	TSH response to TSH-releasing factor	2691	7200	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	GH response to GH-releasing_factor in dementia and its relation with TSH_response_to_TSH-releasing_factor .
11549707	0	GH-releasing_hormone	82,102	GH	49,51	GH-releasing hormone	GH	2691	2688	Gene	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	A low dose of ghrelin stimulates growth_hormone -LRB- GH -RRB- release synergistically with GH-releasing_hormone in humans .
12840904	0	GH-releasing_hormone	53,73	GH	29,31	GH-releasing hormone	GH	2691	2688	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
12840904	0	GH-releasing_hormone	53,73	GHRH	75,79	GH-releasing hormone	GHRH	2691	2691	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
15564325	0	GH-releasing_hormone	63,83	GHRH	85,89	GH-releasing hormone	GHRH	14601(Tax:10090)	14601(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
2108443	0	GH-releasing_hormone	91,111	growth_hormone	64,78	GH-releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Age-related modulatory activity by a cholinergic agonist on the growth_hormone response to GH-releasing_hormone in the rat .
3079770	0	GH-releasing_hormone	41,61	growth_hormone	9,23	GH-releasing hormone	growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Impaired growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in thalassemia major .
3926807	0	GH-releasing_hormone	40,60	growth_hormone	8,22	GH-releasing hormone	growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Blunted growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in hypothyroidism resolves in the euthyroid state .
9503036	0	GH-releasing_hormone	73,93	growth_hormone	32,46	GH-releasing hormone	growth hormone	2691	2688	Gene	Gene	induced|nmod|START_ENTITY secretion|acl|induced secretion|amod|END_ENTITY	Opioid-receptor blockade blunts growth_hormone -LRB- GH -RRB- secretion induced by GH-releasing_hormone in the human male .
16572267	0	GH1	41,44	GHR	75,78	GH1	GHR	2688	2690	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Genetic variation at the growth_hormone -LRB- GH1 -RRB- and growth_hormone_receptor -LRB- GHR -RRB- loci as a risk factor for hypertension and stroke .
16432002	0	GH1	18,21	Growth_hormone_1	0,16	GH1	Growth hormone 1	2688	2688	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Growth_hormone_1 -LRB- GH1 -RRB- gene and performance and post-race rectal temperature during the South African Ironman triathlon .
17223997	0	GH1	22,25	growth_hormone	6,20	GH1	growth hormone	2688	2688	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Human growth_hormone -LRB- GH1 -RRB- gene polymorphism map in a normal-statured adult population .
1730572	0	GH1	77,80	growth_hormone	49,63	GH1	growth hormone	24391(Tax:10116)	81668(Tax:10116)	Gene	Gene	cells|nummod|START_ENTITY secretion|nmod|cells secretion|amod|END_ENTITY	Thyroid_hormone and apotransferrin regulation of growth_hormone secretion by GH1 rat pituitary_tumor cells in iron restricted serum-free defined medium .
7399546	0	GH1	45,48	growth_hormone	14,28	GH1	growth hormone	24391(Tax:10116)	81668(Tax:10116)	Gene	Gene	cells|nummod|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Evaluation of growth_hormone production from GH1 cells in vitro : effect of culture media and time in culture .
15241820	0	GH1	58,61	growth_hormone-1	35,51	GH1	growth hormone-1	2688	2688	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms in the human growth_hormone-1 gene -LRB- GH1 -RRB- and the risk of breast_carcinoma .
12655557	0	GH1	41,44	growth_hormone_1	23,39	GH1	growth hormone 1	24391(Tax:10116)	24391(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations of the growth_hormone_1 -LRB- GH1 -RRB- gene disclosed by modulation of the clinical selection criteria for individuals with short_stature .
16322331	0	GH1	75,78	growth_hormone_1	57,73	GH1	growth hormone 1	2688	2688	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of polymorphisms and haplotypes in the human growth_hormone_1 -LRB- GH1 -RRB- gene with breast_cancer .
15498440	0	GHBP	1,5	IGF-1	7,12	GHBP	IGF-1	2690	3479	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	-LSB- GHBP , IGF-1 and IGFBP-3 serum levels in familial short-statured and normal-statured children -RSB- .
7721104	0	GHF-1	88,93	PIT-1	94,99	GHF-1	PIT-1	5449	5449	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1 / PIT-1 gene .
8666747	0	GHF-1	49,54	PIT-1	55,60	GHF-1	PIT-1	25517(Tax:10116)	25517(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of the pituitary transcription factor GHF-1 / PIT-1 in cell types of the adult porcine adenohypophysis .
8798730	0	GHF-1	0,5	Pit-1	6,11	GHF-1	Pit-1	25517(Tax:10116)	25517(Tax:10116)	Gene	Gene	START_ENTITY|dep|functions functions|compound|END_ENTITY	GHF-1 / Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1 / GHF-1 response element .
9765286	0	GHF-1	8,13	growth_hormone	43,57	GHF-1	growth hormone	25517(Tax:10116)	81668(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of GHF-1 in the regulation of the rat growth_hormone gene promoter by thyroid hormone and retinoic_acid receptors .
16572267	0	GHR	75,78	GH1	41,44	GHR	GH1	2690	2688	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Genetic variation at the growth_hormone -LRB- GH1 -RRB- and growth_hormone_receptor -LRB- GHR -RRB- loci as a risk factor for hypertension and stroke .
18793346	0	GHR	47,50	GH_receptor	34,45	GHR	GH receptor	2690	2690	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Common exon 3 polymorphism of the GH_receptor -LRB- GHR -RRB- gene and effect of GH therapy on growth in Korean children with idiopathic_short_stature -LRB- ISS -RRB- .
26913548	0	GHR	71,74	Growth_Hormone_Receptor	46,69	GHR	Growth Hormone Receptor	100009325(Tax:9986)	100009325(Tax:9986)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Identification of Polymorphisms in the Rabbit Growth_Hormone_Receptor -LRB- GHR -RRB- Gene and Association with Finishing Weight in a Commercial Meat Rabbit Line .
23696513	0	GHR	25,28	Growth_hormone_receptor	0,23	GHR	Growth hormone receptor	2690	2690	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Growth_hormone_receptor -LRB- GHR -RRB- gene polymorphism and Prader-Willi_syndrome .
19884384	0	GHR	91,94	JAK2	131,135	GHR	JAK2	14600(Tax:10090)	16452(Tax:10090)	Gene	Gene	signal|nsubj|START_ENTITY signal|nmod|END_ENTITY	In vivo targeting of the growth_hormone_receptor -LRB- GHR -RRB- Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2 .
12199334	0	GHR	95,98	growth_hormone_receptor	65,88	GHR	growth hormone receptor	2690	2690	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel mutation involving the translation initiation codon of the growth_hormone_receptor gene -LRB- GHR -RRB- in a patient with Laron_syndrome .
16278515	0	GHR	86,89	growth_hormone_receptor	61,84	GHR	growth hormone receptor	2690	2690	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphisms in exon 10 of the chinchilla growth_hormone_receptor -LRB- GHR -RRB- gene .
17044257	0	GHR	87,90	growth_hormone_receptor	62,85	GHR	growth hormone receptor	280805(Tax:9913)	280805(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular evolution of coding and non-coding sequences of the growth_hormone_receptor -LRB- GHR -RRB- gene in the family Bovidae .
20105189	0	GHR	45,48	growth_hormone_receptor	20,43	GHR	growth hormone receptor	2690	2690	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations of the growth_hormone_receptor -LRB- GHR -RRB- gene polymorphisms with adiposity and IGF-I activity in adolescents .
21386799	0	GHR	31,34	growth_hormone_receptor	6,29	GHR	growth hormone receptor	2690	2690	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Human growth_hormone_receptor -LRB- GHR -RRB- expression in obesity : II .
21386804	0	GHR	31,34	growth_hormone_receptor	6,29	GHR	growth hormone receptor	2690	2690	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Human growth_hormone_receptor -LRB- GHR -RRB- expression in obesity : I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women .
25552351	0	GHR	38,41	growth_hormone_receptor	13,36	GHR	growth hormone receptor	2690	2690	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of growth_hormone_receptor -LRB- GHR -RRB- exon 3 and -202 A/C IGFBP-3 genetic polymorphisms on clinical and biochemical features and therapeutic outcome of patients with acromegaly .
26336928	0	GHRELIN	109,116	PAC1	72,76	GHRELIN	PAC1	58991(Tax:10090)	11517(Tax:10090)	Gene	Gene	RECEPTOR|nmod|START_ENTITY RECEPTOR|compound|END_ENTITY	PACAP INTRAPERITONEAL TREATMENT SUPPRESSES APPETITE AND FOOD INTAKE VIA PAC1 RECEPTOR IN MICE , BY INHIBITING GHRELIN , AND INCREASING GLP-1 AND LEPTIN .
8020943	0	GHRF	67,71	growth_hormone-releasing_factor	29,60	GHRF	growth hormone-releasing factor	2691	2691	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic mapping of the human growth_hormone-releasing_factor gene -LRB- GHRF -RRB- using two intragenic polymorphisms detected by PCR amplification .
10594518	0	GHRH	67,71	GH	141,143	GHRH	GH	2691	2688	Gene	Gene	growth_hormone-releasing_hormone|dep|START_ENTITY roles|nmod|growth_hormone-releasing_hormone roles|appos|END_ENTITY	The relative roles of continuous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- and intermittent somatostatin -LRB- 1-14 -RRB- -LRB- SS -RRB- in growth_hormone -LRB- GH -RRB- pulse generation : studies in normal and post cranial irradiated individuals .
10770183	0	GHRH	168,172	GH	29,31	GHRH	GH	2691	2688	Gene	Gene	hormone|appos|START_ENTITY using|dobj|hormone results|acl|using comparison|nmod|results hypothalamic-pituitary_disorders|dep|comparison _|nmod|hypothalamic-pituitary_disorders _|nsubj|Diagnosis Diagnosis|appos|END_ENTITY	Diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in adults with hypothalamic-pituitary_disorders : comparison of test results using pyridostigmine plus GH-releasing hormone -LRB- GHRH -RRB- , clonidine plus GHRH , and insulin-induced hypoglycemia as GH secretagogues .
11455330	0	GHRH	69,73	GH	27,29	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- and growth_hormone_releasing_hormone -LRB- GHRH -RRB- on progesterone and estradiol release from cultured rat granulosa cells .
12446584	0	GHRH	173,177	GH	28,30	GHRH	GH	2691	2688	Gene	Gene	expressing|dobj|START_ENTITY induced|advcl|expressing secretagogues|dep|induced secretagogues|nsubj|Ghrelin Ghrelin|appos|END_ENTITY	Ghrelin and growth_hormone -LRB- GH -RRB- secretagogues potentiate GH-releasing_hormone -LRB- GHRH -RRB- - induced cyclic_adenosine_3 ' ,5 ' - monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors .
12446584	0	GHRH	79,83	GH	28,30	GHRH	GH	2691	2688	Gene	Gene	GH-releasing_hormone|appos|START_ENTITY induced|nsubj|GH-releasing_hormone secretagogues|dep|induced secretagogues|nsubj|Ghrelin Ghrelin|appos|END_ENTITY	Ghrelin and growth_hormone -LRB- GH -RRB- secretagogues potentiate GH-releasing_hormone -LRB- GHRH -RRB- - induced cyclic_adenosine_3 ' ,5 ' - monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors .
12840904	0	GHRH	75,79	GH	29,31	GHRH	GH	2691	2688	Gene	Gene	effect|appos|START_ENTITY effect|appos|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
12938517	0	GHRH	14,18	GH	47,49	GHRH	GH	2691	2688	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of GHRH , GHRP-2 and somatostatin on GH secretion by fetal pituitary .
1454656	0	GHRH	47,51	GH	31,33	GHRH	GH	2691	2688	Gene	Gene	response|xcomp|START_ENTITY response|nsubj|Inhibition Inhibition|appos|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
14763922	0	GHRH	10,14	GH	48,50	GHRH	GH	2691	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNAs mRNAs|amod|vitro vitro|nmod|secretion secretion|compound|END_ENTITY	Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH , pituitary_transcription_factor-1 , GHRH-receptor , GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells .
14763922	0	GHRH	10,14	GH	75,77	GHRH	GH	2691	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|mRNAs mRNAs|amod|vitro vitro|nmod|secretion secretion|nmod|END_ENTITY	Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH , pituitary_transcription_factor-1 , GHRH-receptor , GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells .
15564325	0	GHRH	136,140	GH	41,43	GHRH	GH	14601(Tax:10090)	14599(Tax:10090)	Gene	Gene	analog|compound|START_ENTITY _|nmod|analog _|nsubj|reversibility reversibility|appos|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15564325	0	GHRH	85,89	GH	41,43	GHRH	GH	14601(Tax:10090)	14599(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY _|nmod|mouse _|nsubj|reversibility reversibility|appos|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15638293	0	GHRH	138,142	GH	16,18	GHRH	GH	2691	2688	Gene	Gene	test|compound|START_ENTITY provided|nmod|test variables|acl|provided analysis|nmod|variables peaks|dep|analysis peaks|amod|Growth_hormone Growth_hormone|dep|END_ENTITY	Growth_hormone -LRB- GH -RRB- peaks versus areas under the curve in the diagnosis of adult GH_deficiency : analysis of the variables provided by the GHRH + GHRP-6 test .
1577400	0	GHRH	77,81	GH	61,63	GHRH	GH	2691	2688	Gene	Gene	increases|xcomp|START_ENTITY increases|dobj|responses responses|compound|END_ENTITY	alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects .
16712669	0	GHRH	99,103	GH	60,62	GHRH	GH	2691	2688	Gene	Gene	test|compound|START_ENTITY elicited|nmod|test elicited|nsubj|Effect Effect|nmod|obesity obesity|nmod|secretion secretion|appos|END_ENTITY	Effect of obesity and morbid obesity on the growth_hormone -LRB- GH -RRB- secretion elicited by the combined GHRH + GHRP-6 test .
16835832	0	GHRH	61,65	GH	139,141	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretagogue|nsubj|START_ENTITY secretagogue|nmod|study study|nmod|reserve reserve|compound|END_ENTITY	Recruiting of somatotroph cells after combined somatostatin , GHRH and growth_hormone -LRB- GH -RRB- secretagogue stimulation in a study of pituitary GH reserve in prepuberal female rats .
18095239	6	GHRH	1169,1173	GH	1154,1156	GHRH	GH	2691	2688	Gene	Gene	increased|advcl|START_ENTITY increased|dobj|response response|compound|END_ENTITY	In LC , PD administration markedly increased the GH response to GHRH -LRB- GH peak : 98.0 + / -19.7 ng/ml ; +240 % vs. GHRH alone -RRB- .
19342191	0	GHRH	62,66	GH	37,39	GHRH	GH	780526(Tax:9940)	443329(Tax:9940)	Gene	Gene	modulates|xcomp|START_ENTITY modulates|dobj|response response|compound|END_ENTITY	Ghrelin differentially modulates the GH secretory response to GHRH between the fed and fasted states in sheep .
1943453	0	GHRH	133,137	GH	23,25	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretion|dep|START_ENTITY secretion|nsubj|growth_hormone growth_hormone|appos|END_ENTITY	Robust growth_hormone -LRB- GH -RRB- secretion in aged female rats co-administered GH-releasing hexapeptide -LRB- GHRP-6 -RRB- and GH-releasing_hormone -LRB- GHRH -RRB- .
2104760	0	GHRH	71,75	GH	56,58	GHRH	GH	2691	2688	Gene	Gene	suppress|xcomp|START_ENTITY suppress|dobj|response response|compound|END_ENTITY	Failure of glucose infusion to suppress the exaggerated GH response to GHRH in patients with anorexia_nervosa .
2273206	0	GHRH	115,119	GH	78,80	GHRH	GH	2691	2688	Gene	Gene	GH-releasing_hormone|appos|START_ENTITY induced|nmod|GH-releasing_hormone induced|nsubj|Interaction Interaction|appos|END_ENTITY	Interaction of glucose and pyridostigmine on the secretion of growth_hormone -LRB- GH -RRB- induced by GH-releasing_hormone -LRB- GHRH -RRB- .
2498860	0	GHRH	112,116	GH	90,92	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	responsiveness|xcomp|START_ENTITY growth_hormone|acl:relcl|responsiveness growth_hormone|appos|END_ENTITY	Replenishment of brain catecholamine stores does not restore the impaired growth_hormone -LRB- GH -RRB- responsiveness to GHRH in aged rats .
2545765	0	GHRH	88,92	GH	38,40	GHRH	GH	2691	2688	Gene	Gene	hormone|appos|START_ENTITY response|nmod|hormone response|appos|END_ENTITY	Calcitonin suppresses growth_hormone -LRB- GH -RRB- response to growth_hormone-releasing hormone -LRB- GHRH -RRB- in man .
25613666	0	GHRH	99,103	GH	173,175	GHRH	GH	2691	2688	Gene	Gene	response|nmod|START_ENTITY cells|nmod|response anterior|dobj|cells anterior|advcl|regulating regulating|dobj|END_ENTITY	Alteration of the miRNA expression profile in male porcine anterior pituitary cells in response to GHRH and CST and analysis of the potential roles for miRNAs in regulating GH .
2574645	0	GHRH	64,68	GH	47,49	GHRH	GH	2691	2688	Gene	Gene	Reasons|acl|START_ENTITY Reasons|nmod|variability variability|nmod|responses responses|appos|END_ENTITY	Reasons for the variability in growth_hormone -LRB- GH -RRB- responses to GHRH challenge : the endogenous hypothalamic-somatotroph_rhythm -LRB- HSR -RRB- .
26059749	0	GHRH	111,115	GH	56,58	GHRH	GH	2691	2688	Gene	Gene	administration|compound|START_ENTITY isoforms|nmod|administration isoforms|nsubj|END_ENTITY	Unaltered ratio of circulating levels of growth_hormone / GH isoforms in adults with Prader-Willi_syndrome after GHRH plus arginine administration .
2883595	0	GHRH	138,142	GH	122,124	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	infusions|xcomp|START_ENTITY infusions|nmod|response response|appos|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2883595	0	GHRH	72,76	GH	122,124	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY infusions|nsubj|Effect infusions|nmod|response response|appos|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2911939	0	GHRH	38,42	GH	16,18	GHRH	GH	2691	2688	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|Growth_hormone Growth_hormone|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- responsiveness to GHRH in normal adults is not affected by short-term gonadal blockade .
3104015	0	GHRH	43,47	GH	20,22	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	hormone|appos|START_ENTITY growth_hormone|dep|hormone growth_hormone|appos|END_ENTITY	The growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- - GH-somatomedin axis : evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II .
3107163	0	GHRH	23,27	GH	7,9	GHRH	GH	2691	2688	Gene	Gene	responses|nmod|START_ENTITY responses|nsubj|END_ENTITY	Plasma GH responses to GHRH and other provocative stimuli in idiopathic_GH_deficiency with or without abnormal_delivery .
3119651	0	GHRH	218,222	GH	58,60	GHRH	GH	2691	2688	Gene	Gene	using|advcl|START_ENTITY patients|acl|using Evaluation|dep|patients Evaluation|nmod|hypothalamic_dysfunction hypothalamic_dysfunction|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Evaluation of hypothalamic_dysfunction in growth_hormone -LRB- GH -RRB- - deficient patients using single versus multiple doses of GH-releasing hormone -LRB- GHRH-44 -RRB- and evidence for diurnal variation in somatotroph responsiveness to GHRH in GH-deficient patients .
7593423	0	GHRH	98,102	GH	27,29	GHRH	GH	2691	2688	Gene	Gene	hormone|appos|START_ENTITY administration|nmod|hormone secretion|nmod|administration secretion|nsubj|Absence Absence|appos|END_ENTITY	Absence of growth_hormone -LRB- GH -RRB- secretion after the administration of either GH-releasing hormone -LRB- GHRH -RRB- , GH-releasing peptide -LRB- GHRP-6 -RRB- , or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection .
7729789	0	GHRH	57,61	GH	8,10	GHRH	GH	2691	2688	Gene	Gene	growth_hormone-releasing_hormone|xcomp|START_ENTITY Blunted|advcl|growth_hormone-releasing_hormone Blunted|dobj|response response|compound|END_ENTITY	Blunted GH response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- alone or combined with arginine in non-insulin-dependent_diabetes_mellitus .
7746092	0	GHRH	125,129	GH	83,85	GHRH	GH	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Modulation of long-term memory and extinction responses induced by growth_hormone -LRB- GH -RRB- and growth_hormone_releasing_hormone -LRB- GHRH -RRB- in rats .
8349808	0	GHRH	82,86	GH	31,33	GHRH	GH	2691	2688	Gene	Gene	hormone|appos|START_ENTITY secretion|nmod|hormone secretion|appos|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- secretion by a selective GH-releasing hormone -LRB- GHRH -RRB- antagonist .
8349808	1	GHRH	146,150	GH	172,174	GHRH	GH	2691	2688	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|END_ENTITY	Direct evidence for involvement of endogenous GHRH in the generation of GH pulses .
8421084	0	GHRH	49,53	GH	116,118	GHRH	GH	2691	2688	Gene	Gene	hormone|appos|START_ENTITY hormone|appos|atropine atropine|nmod|secretion secretion|compound|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
8421084	0	GHRH	49,53	GH	26,28	GHRH	GH	2691	2688	Gene	Gene	hormone|appos|START_ENTITY Effect|dep|hormone Effect|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
8513607	0	GHRH	129,133	GH	79,81	GHRH	GH	2691	2688	Gene	Gene	stimulation|appos|START_ENTITY response|nmod|stimulation response|appos|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
9024267	0	GHRH	108,112	GH	31,33	GHRH	GH	2691	2688	Gene	Gene	antagonist|compound|START_ENTITY hypersecretion|nmod|antagonist hypersecretion|nsubj|Suppression Suppression|appos|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
9024267	0	GHRH	87,91	GH	31,33	GHRH	GH	2691	2688	Gene	Gene	GH-releasing_hormone|appos|START_ENTITY due|nmod|GH-releasing_hormone hypersecretion|xcomp|due hypersecretion|nsubj|Suppression Suppression|appos|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
12840904	0	GHRH	75,79	GH-releasing_hormone	53,73	GHRH	GH-releasing hormone	2691	2691	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
15564325	0	GHRH	85,89	GH-releasing_hormone	63,83	GHRH	GH-releasing hormone	14601(Tax:10090)	14601(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15638293	0	GHRH	138,142	Growth_hormone	0,14	GHRH	Growth hormone	2691	2688	Gene	Gene	test|compound|START_ENTITY provided|nmod|test variables|acl|provided analysis|nmod|variables peaks|dep|analysis peaks|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- peaks versus areas under the curve in the diagnosis of adult GH_deficiency : analysis of the variables provided by the GHRH + GHRP-6 test .
2889308	0	GHRH	51,55	Growth_hormone	0,14	GHRH	Growth hormone	2691	2688	Gene	Gene	responses|nmod|START_ENTITY END_ENTITY|dobj|responses	Growth_hormone responses to the releasing hormones GHRH and GnRH and the inhibitors somatostatin and bromocriptine in TRH-responsive and non-responsive acromegalics .
2911939	0	GHRH	38,42	Growth_hormone	0,14	GHRH	Growth hormone	2691	2688	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- responsiveness to GHRH in normal adults is not affected by short-term gonadal blockade .
7788012	0	GHRH	61,65	Growth_hormone	0,14	GHRH	Growth hormone	2691	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- , insulin , clonidine and arginine after GHRH pretreatment in obese children : evidence of somatostatin increase ?
8959075	0	GHRH	27,31	Growth_hormone	0,14	GHRH	Growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to GHRH , GHRP-6 and GHRH + GHRP-6 in patients with polycystic_ovary_syndrome .
9509075	0	GHRH	37,41	Growth_hormone	0,14	GHRH	Growth hormone	2691	2688	Gene	Gene	GHRP-6|compound|START_ENTITY elicited|nmod|GHRP-6 elicited|nsubj|secretion secretion|amod|END_ENTITY	Growth_hormone secretion elicited by GHRH , GHRP-6 or GHRH plus GHRP-6 in patients with microprolactinoma and macroprolactinoma before and after bromocriptine therapy .
12538852	0	GHRH	34,38	Growth_hormone-releasing_hormone	0,32	GHRH	Growth hormone-releasing hormone	2691	2691	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Growth_hormone-releasing_hormone -LRB- GHRH -RRB- antagonists inhibit the proliferation of androgen-dependent and - independent prostate_cancers .
10633224	0	GHRH	41,45	Leptin	0,6	GHRH	Leptin	29446(Tax:10116)	25608(Tax:10116)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Leptin increases in vivo GH responses to GHRH and GH-releasing_peptide-6 in food-deprived rats .
10594518	0	GHRH	67,71	growth_hormone	125,139	GHRH	growth hormone	2691	2688	Gene	Gene	growth_hormone-releasing_hormone|dep|START_ENTITY roles|nmod|growth_hormone-releasing_hormone roles|nmod|END_ENTITY	The relative roles of continuous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- and intermittent somatostatin -LRB- 1-14 -RRB- -LRB- SS -RRB- in growth_hormone -LRB- GH -RRB- pulse generation : studies in normal and post cranial irradiated individuals .
10770183	0	GHRH	168,172	growth_hormone	13,27	GHRH	growth hormone	2691	2688	Gene	Gene	hormone|appos|START_ENTITY using|dobj|hormone results|acl|using comparison|nmod|results hypothalamic-pituitary_disorders|dep|comparison _|nmod|hypothalamic-pituitary_disorders _|nsubj|Diagnosis Diagnosis|nmod|_ _|amod|END_ENTITY	Diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in adults with hypothalamic-pituitary_disorders : comparison of test results using pyridostigmine plus GH-releasing hormone -LRB- GHRH -RRB- , clonidine plus GHRH , and insulin-induced hypoglycemia as GH secretagogues .
12740741	0	GHRH	60,64	growth_hormone	102,116	GHRH	growth hormone	2691	2688	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|response response|nmod|END_ENTITY	Involvement of endogenous growth_hormone-releasing_hormone -LRB- GHRH -RRB- in the exercise-related response of growth_hormone .
12840904	0	GHRH	75,79	growth_hormone	13,27	GHRH	growth hormone	2691	2688	Gene	Gene	effect|appos|START_ENTITY END_ENTITY|dobj|effect	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
12864804	0	GHRH	32,36	growth_hormone	89,103	GHRH	growth hormone	2691	2688	Gene	Gene	effectiveness|nmod|START_ENTITY test|nsubj|effectiveness test|advcl|test test|acl|diagnosing diagnosing|dobj|deficiency deficiency|amod|END_ENTITY	The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth_hormone deficiency in adults .
12864804	0	GHRH	56,60	growth_hormone	89,103	GHRH	growth hormone	2691	2688	Gene	Gene	test|compound|START_ENTITY test|acl|diagnosing diagnosing|dobj|deficiency deficiency|amod|END_ENTITY	The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth_hormone deficiency in adults .
1454656	0	GHRH	47,51	growth_hormone	15,29	GHRH	growth hormone	2691	2688	Gene	Gene	response|xcomp|START_ENTITY response|nsubj|Inhibition Inhibition|nmod|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
1553429	0	GHRH	74,78	growth_hormone	25,39	GHRH	growth hormone	485863(Tax:9615)	403795(Tax:9615)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|propranolol propranolol|nmod|response response|amod|END_ENTITY	Effect of propranolol on growth_hormone response to GH_releasing_hormone -LRB- GHRH 1-44 -RRB- in the dog .
15564325	0	GHRH	136,140	growth_hormone	25,39	GHRH	growth hormone	14601(Tax:10090)	14599(Tax:10090)	Gene	Gene	analog|compound|START_ENTITY _|nmod|analog _|nsubj|reversibility reversibility|nmod|_ _|amod|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15564325	0	GHRH	85,89	growth_hormone	25,39	GHRH	growth hormone	14601(Tax:10090)	14599(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY _|nmod|mouse _|nsubj|reversibility reversibility|nmod|_ _|amod|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15809015	0	GHRH	64,68	growth_hormone	23,37	GHRH	growth hormone	2691	2688	Gene	Gene	stimulus|compound|START_ENTITY isoforms|nmod|stimulus isoforms|csubj|Circulating Circulating|dobj|END_ENTITY	Circulating non-22 kDa growth_hormone isoforms after a repeated GHRH stimulus in normal subjects .
15979916	0	GHRH	88,92	growth_hormone	29,43	GHRH	growth hormone	14601(Tax:10090)	14599(Tax:10090)	Gene	Gene	composition|nmod|START_ENTITY treatment|nmod|composition knock|nsubj|treatment END_ENTITY|ccomp|knock	Effects of recombinant mouse growth_hormone treatment on growth and body composition in GHRH knock out mice .
16712669	0	GHRH	99,103	growth_hormone	44,58	GHRH	growth hormone	2691	2688	Gene	Gene	test|compound|START_ENTITY elicited|nmod|test elicited|nsubj|Effect Effect|nmod|obesity obesity|nmod|secretion secretion|amod|END_ENTITY	Effect of obesity and morbid obesity on the growth_hormone -LRB- GH -RRB- secretion elicited by the combined GHRH + GHRP-6 test .
1890280	0	GHRH	55,59	growth_hormone	22,36	GHRH	growth hormone	2691	2688	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|Restoration Restoration|nmod|END_ENTITY	Restoration of normal growth_hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline .
1943453	0	GHRH	133,137	growth_hormone	7,21	GHRH	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretion|dep|START_ENTITY secretion|nsubj|END_ENTITY	Robust growth_hormone -LRB- GH -RRB- secretion in aged female rats co-administered GH-releasing hexapeptide -LRB- GHRP-6 -RRB- and GH-releasing_hormone -LRB- GHRH -RRB- .
20843274	0	GHRH	221,225	growth_hormone	14,28	GHRH	growth hormone	2691	2688	Gene	Gene	use|nmod|START_ENTITY perspectives|nmod|use GHRH|dep|perspectives GHRH|amod|Difference Difference|nmod|response response|amod|END_ENTITY	Difference in growth_hormone response to growth_hormone-releasing hormone -LRB- GHRH -RRB- testing following GHRH subacute treatment in normal aging and growth_hormone-deficient adults : possible perspectives for therapeutic use of GHRH or its analogs in elderly subjects ?
20843274	0	GHRH	75,79	growth_hormone	14,28	GHRH	growth hormone	2691	2688	Gene	Gene	hormone|appos|START_ENTITY Difference|nmod|hormone Difference|nmod|response response|amod|END_ENTITY	Difference in growth_hormone response to growth_hormone-releasing hormone -LRB- GHRH -RRB- testing following GHRH subacute treatment in normal aging and growth_hormone-deficient adults : possible perspectives for therapeutic use of GHRH or its analogs in elderly subjects ?
20843274	0	GHRH	99,103	growth_hormone	14,28	GHRH	growth hormone	2691	2688	Gene	Gene	START_ENTITY|amod|Difference Difference|nmod|response response|amod|END_ENTITY	Difference in growth_hormone response to growth_hormone-releasing hormone -LRB- GHRH -RRB- testing following GHRH subacute treatment in normal aging and growth_hormone-deficient adults : possible perspectives for therapeutic use of GHRH or its analogs in elderly subjects ?
2113855	0	GHRH	85,89	growth_hormone	20,34	GHRH	growth hormone	2691	2688	Gene	Gene	hormone|appos|START_ENTITY Discordance|nmod|hormone Discordance|nmod|responses responses|amod|END_ENTITY	Discordance between growth_hormone responses after growth_hormone-releasing hormone -LRB- GHRH -RRB- and insulin_hypoglycemia in ectopic_GHRH_syndrome .
2114240	0	GHRH	87,91	growth_hormone	35,49	GHRH	growth hormone	2691	2688	Gene	Gene	responses|acl|START_ENTITY rise|dobj|responses rise|nsubj|Effect Effect|nmod|glucose glucose|nmod|END_ENTITY	Effect of oral glucose on the late growth_hormone rise and growth_hormone responses to GHRH in normal subjects .
2273206	0	GHRH	115,119	growth_hormone	62,76	GHRH	growth hormone	2691	2688	Gene	Gene	GH-releasing_hormone|appos|START_ENTITY induced|nmod|GH-releasing_hormone induced|nsubj|Interaction Interaction|nmod|secretion secretion|nmod|END_ENTITY	Interaction of glucose and pyridostigmine on the secretion of growth_hormone -LRB- GH -RRB- induced by GH-releasing_hormone -LRB- GHRH -RRB- .
2497615	0	GHRH	67,71	growth_hormone	40,54	GHRH	growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Influence of estrogen administration on growth_hormone response to GHRH and L-Dopa in patients with Turner 's _ syndrome .
2498860	0	GHRH	112,116	growth_hormone	74,88	GHRH	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	responsiveness|xcomp|START_ENTITY END_ENTITY|acl:relcl|responsiveness	Replenishment of brain catecholamine stores does not restore the impaired growth_hormone -LRB- GH -RRB- responsiveness to GHRH in aged rats .
2515143	0	GHRH	81,85	growth_hormone	110,124	GHRH	growth hormone	2691	2688	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of acute intravenous injection of two growth_hormone-releasing hormones -LRB- GHRH 1-40 and 1-29 -RRB- on serum growth_hormone and other pituitary hormones in short children with pulsatile growth_hormone secretion .
2515143	0	GHRH	81,85	growth_hormone	187,201	GHRH	growth hormone	2691	2688	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|growth_hormone growth_hormone|nmod|children children|nmod|secretion secretion|compound|END_ENTITY	Effects of acute intravenous injection of two growth_hormone-releasing hormones -LRB- GHRH 1-40 and 1-29 -RRB- on serum growth_hormone and other pituitary hormones in short children with pulsatile growth_hormone secretion .
2545765	0	GHRH	88,92	growth_hormone	22,36	GHRH	growth hormone	2691	2688	Gene	Gene	hormone|appos|START_ENTITY response|nmod|hormone response|amod|END_ENTITY	Calcitonin suppresses growth_hormone -LRB- GH -RRB- response to growth_hormone-releasing hormone -LRB- GHRH -RRB- in man .
2546369	0	GHRH	65,69	growth_hormone	102,116	GHRH	growth hormone	2691	2688	Gene	Gene	growth_hormone-releasing_hormone|dep|START_ENTITY infusions|nsubj|growth_hormone-releasing_hormone infusions|ccomp|augment augment|dobj|secretion secretion|amod|END_ENTITY	Use of continuous subcutaneous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- infusions to augment growth_hormone secretion and to promote growth .
2546370	0	GHRH	125,129	growth_hormone	176,190	GHRH	growth hormone	2691	2688	Gene	Gene	subcutaneous|parataxis|START_ENTITY subcutaneous|nmod|children children|nmod|secretion secretion|compound|END_ENTITY	Modification of 24-hour growth_hormone secretion after continuous subcutaneous infusion of growth_hormone-releasing hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- in short children with low 24-hour growth_hormone secretion .
2546370	0	GHRH	125,129	growth_hormone	24,38	GHRH	growth hormone	2691	2688	Gene	Gene	subcutaneous|parataxis|START_ENTITY subcutaneous|nsubj|Modification Modification|nmod|secretion secretion|compound|END_ENTITY	Modification of 24-hour growth_hormone secretion after continuous subcutaneous infusion of growth_hormone-releasing hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- in short children with low 24-hour growth_hormone secretion .
2565570	0	GHRH	112,116	growth_hormone	85,99	GHRH	growth hormone	2691	2688	Gene	Gene	enhances|xcomp|START_ENTITY enhances|dobj|response response|compound|END_ENTITY	Reduction of the effects of growth_hormone_release_inhibiting_factor enhances plasma growth_hormone response to GHRH .
2574645	0	GHRH	64,68	growth_hormone	31,45	GHRH	growth hormone	2691	2688	Gene	Gene	Reasons|acl|START_ENTITY Reasons|nmod|variability variability|nmod|responses responses|amod|END_ENTITY	Reasons for the variability in growth_hormone -LRB- GH -RRB- responses to GHRH challenge : the endogenous hypothalamic-somatotroph_rhythm -LRB- HSR -RRB- .
25931044	0	GHRH	22,26	growth_hormone	66,80	GHRH	growth hormone	2691	2688	Gene	Gene	stimulation|compound|START_ENTITY usefulness|nmod|stimulation test|nsubj|usefulness test|nmod|diagnostics diagnostics|nmod|deficiency deficiency|amod|END_ENTITY	The usefulness of the GHRH stimulation test in the diagnostics of growth_hormone deficiency in children .
26059749	0	GHRH	111,115	growth_hormone	41,55	GHRH	growth hormone	2691	2688	Gene	Gene	administration|compound|START_ENTITY isoforms|nmod|administration ratio|parataxis|isoforms ratio|acl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Unaltered ratio of circulating levels of growth_hormone / GH isoforms in adults with Prader-Willi_syndrome after GHRH plus arginine administration .
2883595	0	GHRH	138,142	growth_hormone	106,120	GHRH	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	infusions|xcomp|START_ENTITY infusions|nmod|response response|amod|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2883595	0	GHRH	72,76	growth_hormone	106,120	GHRH	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY infusions|nsubj|Effect infusions|nmod|response response|amod|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
3096623	0	GHRH	77,81	growth_hormone	96,110	GHRH	growth hormone	2691	2688	Gene	Gene	effect|appos|START_ENTITY NH2|nsubj|effect NH2|nmod|secretion secretion|amod|END_ENTITY	The effect of intravenous , subcutaneous , and intranasal GH-RH analog , -LSB- Nle27 -RSB- GHRH -LRB- 1-29 -RRB- - NH2 , on growth_hormone secretion in normal men : dose-response relationships .
3104015	0	GHRH	43,47	growth_hormone	4,18	GHRH	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	hormone|appos|START_ENTITY END_ENTITY|dep|hormone	The growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- - GH-somatomedin axis : evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II .
3119651	0	GHRH	218,222	growth_hormone	42,56	GHRH	growth hormone	2691	2688	Gene	Gene	using|advcl|START_ENTITY patients|acl|using Evaluation|dep|patients Evaluation|nmod|hypothalamic_dysfunction hypothalamic_dysfunction|nmod|END_ENTITY	Evaluation of hypothalamic_dysfunction in growth_hormone -LRB- GH -RRB- - deficient patients using single versus multiple doses of GH-releasing hormone -LRB- GHRH-44 -RRB- and evidence for diurnal variation in somatotroph responsiveness to GHRH in GH-deficient patients .
7593423	0	GHRH	98,102	growth_hormone	11,25	GHRH	growth hormone	2691	2688	Gene	Gene	hormone|appos|START_ENTITY administration|nmod|hormone secretion|nmod|administration secretion|nsubj|Absence Absence|nmod|END_ENTITY	Absence of growth_hormone -LRB- GH -RRB- secretion after the administration of either GH-releasing hormone -LRB- GHRH -RRB- , GH-releasing peptide -LRB- GHRP-6 -RRB- , or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection .
7932284	0	GHRH	34,38	growth_hormone	96,110	GHRH	growth hormone	2691	2688	Gene	Gene	Growth_hormone-releasing_hormone|appos|START_ENTITY Growth_hormone-releasing_hormone|dep|effects effects|nmod|END_ENTITY	Growth_hormone-releasing_hormone -LRB- GHRH -RRB- - induced effects on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression .
8349808	0	GHRH	82,86	growth_hormone	15,29	GHRH	growth hormone	2691	2688	Gene	Gene	hormone|appos|START_ENTITY secretion|nmod|hormone secretion|amod|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- secretion by a selective GH-releasing hormone -LRB- GHRH -RRB- antagonist .
8421084	0	GHRH	49,53	growth_hormone	10,24	GHRH	growth hormone	2691	2688	Gene	Gene	hormone|appos|START_ENTITY Effect|dep|hormone Effect|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
8513607	0	GHRH	129,133	growth_hormone	63,77	GHRH	growth hormone	2691	2688	Gene	Gene	stimulation|appos|START_ENTITY response|nmod|stimulation response|amod|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
8588384	0	GHRH	45,49	growth_hormone	91,105	GHRH	growth hormone	2691	2688	Gene	Gene	growth_hormone_releasing_hormone|appos|START_ENTITY Action|nmod|growth_hormone_releasing_hormone EEG|nsubj|Action EEG|dobj|secretion secretion|nmod|END_ENTITY	-LSB- Action of growth_hormone_releasing_hormone -LRB- GHRH -RRB- on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression -RSB- .
8851324	0	GHRH	85,89	growth_hormone	13,27	GHRH	growth hormone	2691	2688	Gene	Gene	Behavior|appos|START_ENTITY Behavior|nmod|END_ENTITY	-LSB- Behavior of growth_hormone after stimulation with growth_hormone_releasing_hormone -LRB- GHRH -RRB- in children with disorders_of_the_hypothalamo-hypophyseal_axis and girls with Turner_syndrome -RSB- .
9024267	0	GHRH	108,112	growth_hormone	15,29	GHRH	growth hormone	2691	2688	Gene	Gene	antagonist|compound|START_ENTITY hypersecretion|nmod|antagonist hypersecretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
9024267	0	GHRH	87,91	growth_hormone	15,29	GHRH	growth hormone	2691	2688	Gene	Gene	GH-releasing_hormone|appos|START_ENTITY due|nmod|GH-releasing_hormone hypersecretion|xcomp|due hypersecretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
12740741	0	GHRH	60,64	growth_hormone-releasing_hormone	26,58	GHRH	growth hormone-releasing hormone	2691	2691	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of endogenous growth_hormone-releasing_hormone -LRB- GHRH -RRB- in the exercise-related response of growth_hormone .
20509930	0	GHRH	62,66	growth_hormone-releasing_hormone	28,60	GHRH	growth hormone-releasing hormone	2691	2691	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Antiproliferative effect of growth_hormone-releasing_hormone -LRB- GHRH -RRB- antagonist on ovarian_cancer cells through the EGFR-Akt pathway .
21854358	0	GHRH	59,63	growth_hormone-releasing_hormone	25,57	GHRH	growth hormone-releasing hormone	2691	2691	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Antineoplastic action of growth_hormone-releasing_hormone -LRB- GHRH -RRB- antagonists .
2551950	0	GHRH	45,49	growth_hormone-releasing_hormone	11,43	GHRH	growth hormone-releasing hormone	2691	2691	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone-releasing_hormone -LRB- GHRH -RRB- on densely granulated somatotroph_adenomas and sparsely granulated somatotroph_adenomas in vitro : a morphological and functional investigation .
8032940	0	GHRH	74,78	growth_hormone-releasing_hormone	40,72	GHRH	growth hormone-releasing hormone	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Alterations of adenylyl cyclase-coupled growth_hormone-releasing_hormone -LRB- GHRH -RRB- pituitary receptors in different conditions of GHRH deprivation .
8745060	0	GHRH	54,58	growth_hormone-releasing_hormone	20,52	GHRH	growth hormone-releasing hormone	2691	2691	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of growth_hormone-releasing_hormone -LRB- GHRH -RRB- binding to cloned porcine_GHRH_receptor .
1971774	0	GHRH	38,42	growth_hormone_releasing_hormone	4,36	GHRH	growth hormone releasing hormone	2691	2691	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The growth_hormone_releasing_hormone -LRB- GHRH -RRB- response to a mixed meal is blunted in young adults with insulin-dependent_diabetes_mellitus whereas the somatostatin response is normal .
2543179	0	GHRH	7,11	placental_lactogen	46,64	GHRH	placental lactogen	2691	1443	Gene	Gene	START_ENTITY|appos|concentrations concentrations|compound|END_ENTITY	Plasma GHRH , CRH , ACTH , beta-endorphin , human placental_lactogen , GH and cortisol concentrations at the third trimester of pregnancy .
16469800	0	GHRH-R	73,79	growth_hormone-releasing_hormone_receptor	30,71	GHRH-R	growth hormone-releasing hormone receptor	420385(Tax:9031)	420385(Tax:9031)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Identification of the chicken growth_hormone-releasing_hormone_receptor -LRB- GHRH-R -RRB- mRNA and gene : regulation of anterior pituitary GHRH-R mRNA levels by homologous and heterologous hormones .
15336233	0	GHRHR	73,78	growth_hormone_releasing_hormone_receptor	30,71	GHRHR	growth hormone releasing hormone receptor	2692	2692	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A nonsense mutation -LRB- E72X -RRB- in growth_hormone_releasing_hormone_receptor -LRB- GHRHR -RRB- gene is the major cause of familial isolated growth_hormone_deficiency in Western region of India : founder effect suggested by analysis of dinucleotide repeat polymorphism close to GHRHR gene .
20354904	0	GHRHR	92,97	growth_hormone_releasing_hormone_receptor	49,90	GHRHR	growth hormone releasing hormone receptor	102184221	102184221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of genetic variability of the dairy goat growth_hormone_releasing_hormone_receptor -LRB- GHRHR -RRB- gene on growth traits .
19361568	0	GHS-R	18,23	Ghrelin	0,7	GHS-R	Ghrelin	100136603(Tax:8022)	59301(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Ghrelin receptor -LRB- GHS-R -RRB- - like receptor and its genomic organisation in rainbow_trout , Oncorhynchus_mykiss .
12050285	0	GHS-R	77,82	ghrelin	39,46	GHS-R	ghrelin	2693	59301(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY distribution|nmod|receptor distribution|nmod|mRNA mRNA|nmod|END_ENTITY	The tissue distribution of the mRNA of ghrelin and subtypes of its receptor , GHS-R , in humans .
16043264	0	GHS-R	74,79	ghrelin	65,72	GHS-R	ghrelin	84022(Tax:10116)	59301(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|receptor receptor|appos|END_ENTITY	Immunohistochemical localization of orexin-B , orexin-1 receptor , ghrelin , GHS-R in the lacrimal gland of normal and diabetic rats .
21269967	0	GHS-R	40,45	ghrelin	15,22	GHS-R	ghrelin	84022(Tax:10116)	59301(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of ghrelin and its receptor GHS-R in the hypothalamus and gastrointestinal tract in rats with chronic_renal_failure -RSB- .
24468548	0	GHS-R	60,65	ghrelin	40,47	GHS-R	ghrelin	2693	58991(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|analog analog|nmod|END_ENTITY	Characterization of a far-red analog of ghrelin for imaging GHS-R in P19-derived cardiomyocytes .
9348177	0	GHS-R	51,56	growth_hormone_secretagogue-receptor	13,49	GHS-R	growth hormone secretagogue-receptor	84022(Tax:10116)	84022(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Hypothalamic growth_hormone_secretagogue-receptor -LRB- GHS-R -RRB- expression is regulated by growth hormone in the rat .
15380232	0	GHS-R	70,75	growth_hormone_secretagogue_receptor	32,68	GHS-R	growth hormone secretagogue receptor	2693	2693	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Novel isoxazole_carboxamides as growth_hormone_secretagogue_receptor -LRB- GHS-R -RRB- antagonists .
20658315	0	GHSR	64,68	growth_hormone_secretagogue_receptor	26,62	GHSR	growth hormone secretagogue receptor	102173610	102173610	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel SNPs of the caprine growth_hormone_secretagogue_receptor -LRB- GHSR -RRB- gene and their association with growth traits in goats .
22735618	0	GHSR	54,58	growth_hormone_secretagogue_receptor	16,52	GHSR	growth hormone secretagogue receptor	443238(Tax:9940)	443238(Tax:9940)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Associations of growth_hormone_secretagogue_receptor -LRB- GHSR -RRB- genes polymorphisms and protein structure changes with carcass traits in sheep .
7673420	0	GH_binding_protein	93,111	growth_hormone	42,56	GH binding protein	growth hormone	2690	2688	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Acute and chronic effects of subcutaneous growth_hormone -LRB- GH -RRB- injections on plasma levels of GH_binding_protein in short children .
18793346	0	GH_receptor	34,45	GHR	47,50	GH receptor	GHR	2690	2690	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Common exon 3 polymorphism of the GH_receptor -LRB- GHR -RRB- gene and effect of GH therapy on growth in Korean children with idiopathic_short_stature -LRB- ISS -RRB- .
16614389	0	GH_receptor	57,68	IGF-I	81,86	GH receptor	IGF-I	2690	16000(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|dep|END_ENTITY	A GH_receptor antisense oligonucleotide inhibits hepatic GH_receptor expression , IGF-I production and body weight_gain in normal mice .
7475906	0	GH_receptor	60,71	growth_hormone	22,36	GH receptor	growth hormone	25235(Tax:10116)	81668(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY administration|amod|END_ENTITY	Effect of fasting and growth_hormone -LRB- GH -RRB- administration on GH_receptor -LRB- GHR -RRB- messenger ribonucleic acid -LRB- mRNA -RRB- and GH-binding protein -LRB- GHBP -RRB- mRNA levels in male rats .
8894644	0	GH_receptor	100,111	growth_hormone	62,76	GH receptor	growth hormone	443333(Tax:9940)	443329(Tax:9940)	Gene	Gene	administration|nmod|START_ENTITY administration|amod|END_ENTITY	Differential effects of maternal ovine placental_lactogen and growth_hormone -LRB- GH -RRB- administration on GH_receptor , insulin-like_growth_factor _ -LRB- IGF -RRB- -1 and IGF binding protein-3 gene expression in the pregnant and fetal sheep .
1553429	0	GH_releasing_hormone	52,72	growth_hormone	25,39	GH releasing hormone	growth hormone	485863(Tax:9615)	403795(Tax:9615)	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Effect of propranolol on growth_hormone response to GH_releasing_hormone -LRB- GHRH 1-44 -RRB- in the dog .
15923610	0	GI-GPx	4,10	Nrf2	32,36	GI-GPx	Nrf2	2877	4780	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	The GI-GPx gene is a target for Nrf2 .
21323725	0	GI-GPx	68,74	gastrointestinal_glutathione_peroxidase	27,66	GI-GPx	gastrointestinal glutathione peroxidase	14776(Tax:10090)	14776(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Differential expression of gastrointestinal_glutathione_peroxidase -LRB- GI-GPx -RRB- gene during mouse organogenesis .
19429458	0	GIF	55,58	GDNF-inducible_transcription_factor	18,53	GIF	GDNF-inducible transcription factor	14603(Tax:10090)	14603(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Activation of the GDNF-inducible_transcription_factor -LRB- GIF -RRB- gene promoter by glucocorticoid and progesterone .
7655350	0	GIF	40,43	growth_inhibitory_factor	14,38	GIF	growth inhibitory factor	117038(Tax:10116)	117038(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of growth_inhibitory_factor -LRB- GIF -RRB- in normal and injured rat brains .
9593981	0	GIF	105,108	metallothionein-III	84,103	GIF	metallothionein-III	14603(Tax:10090)	17751(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Stimulatory effects of 4-methylcatechol , dopamine and levodopa on the expression of metallothionein-III -LRB- GIF -RRB- mRNA in immortalized mouse brain glial cells -LRB- VR-2g -RRB- .
18358451	0	GIGYF2	17,23	PARK11	45,51	GIGYF2	PARK11	26058	26058	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Mutations in the GIGYF2 -LRB- TNRC15 -RRB- gene at the PARK11 locus in familial_Parkinson_disease .
18358451	0	GIGYF2	17,23	TNRC15	25,31	GIGYF2	TNRC15	26058	26058	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the GIGYF2 -LRB- TNRC15 -RRB- gene at the PARK11 locus in familial_Parkinson_disease .
23440419	0	GILZ	82,86	DC-SCRIPT	0,9	GILZ	DC-SCRIPT	1831	167465	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	DC-SCRIPT regulates glucocorticoid_receptor function and expression of its target GILZ in dendritic cells .
15031210	0	GILZ	0,4	FoxO3	48,53	GILZ	FoxO3	14605(Tax:10090)	56484(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	GILZ , a new target for the transcription factor FoxO3 , protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis .
17910039	0	GILZ	39,43	Glucocorticoid-induced_leucine_zipper	0,37	GILZ	Glucocorticoid-induced leucine zipper	1831	1831	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression .
19875485	0	GILZ	48,52	glucocorticoid-induced_leucine_zipper	4,41	GILZ	glucocorticoid-induced leucine zipper	1831	1831	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The glucocorticoid-induced_leucine_zipper gene -LRB- GILZ -RRB- expression decreases after successful treatment of patients with endogenous Cushing 's _ syndrome and may play a role in glucocorticoid-induced_osteoporosis .
20970683	0	GILZ	47,51	glucocorticoid-induced_leucine_zipper	8,45	GILZ	glucocorticoid-induced leucine zipper	1831	1831	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Role of glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- expression by dendritic cells in tolerance induction .
23090754	0	GILZ	53,57	glucocorticoid-induced_leucine_zipper	14,51	GILZ	glucocorticoid-induced leucine zipper	83514(Tax:10116)	83514(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- in cardiomyocytes .
23494955	0	GILZ	69,73	glucocorticoid-induced_leucine_zipper	30,67	GILZ	glucocorticoid-induced leucine zipper	1831	1831	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variants in the human glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- gene in fertile and infertile men .
24860090	0	GILZ	47,51	glucocorticoid-induced_leucine_zipper	8,45	GILZ	glucocorticoid-induced leucine zipper	14605(Tax:10090)	14605(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- in bone acquisition .
23440419	0	GILZ	82,86	glucocorticoid_receptor	20,43	GILZ	glucocorticoid receptor	1831	2908	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	DC-SCRIPT regulates glucocorticoid_receptor function and expression of its target GILZ in dendritic cells .
15031210	0	GILZ	0,4	interleukin-2	83,96	GILZ	interleukin-2	14605(Tax:10090)	16183(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|amod|END_ENTITY	GILZ , a new target for the transcription factor FoxO3 , protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis .
24204963	0	GIMAP6	25,31	GABARAPL2	66,75	GIMAP6	GABARAPL2	474344	11345	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The immune system GTPase GIMAP6 interacts with the Atg8 homologue GABARAPL2 and is recruited to autophagosomes .
2437570	0	GIP	0,3	CCK	16,19	GIP	CCK	25040(Tax:10116)	25298(Tax:10116)	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	GIP potentiates CCK stimulated pancreatic enzyme secretion : correlation of anatomical structures with the effects of GIP and CCK on amylase secretion .
6130663	0	GIP	47,50	CCK-8	73,78	GIP	CCK-8	14607(Tax:10090)	12424(Tax:10090)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Interaction of gastric inhibitory polypeptide -LRB- GIP -RRB- and cholecystokinin -LRB- CCK-8 -RRB- with basal and stimulated insulin secretion in mice .
12713798	0	GIP	145,148	DPP_IV	0,6	GIP	DPP IV	2695	1803	Gene	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	DPP_IV resistance and insulin releasing activity of a novel di-substituted analogue of glucose-dependent_insulinotropic_polypeptide , -LRB- Ser2-Asp13 -RRB- GIP .
15183115	0	GIP	49,52	GLP-1	27,32	GIP	GLP-1	25040(Tax:10116)	24952(Tax:10116)	Gene	Gene	influence|nsubj|START_ENTITY influence|advcl|vitro vitro|nmod|END_ENTITY	Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness .
15579061	0	GIP	117,120	GLP-1	60,65	GIP	GLP-1	2695	2641	Gene	Gene	glucagon-like_peptide-1|appos|START_ENTITY glucagon-like_peptide-1|appos|END_ENTITY	Structurally modified analogues of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- and glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- as future antidiabetic agents .
21330636	0	GIP	0,3	GLP-1	52,57	GIP	GLP-1	2695	2641	Gene	Gene	potentiate|nsubj|START_ENTITY potentiate|dobj|effects effects|nmod|END_ENTITY	GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes .
21386059	0	GIP	61,64	GLP-1	66,71	GIP	GLP-1	2695	2641	Gene	Gene	hormones|appos|START_ENTITY impact|nmod|hormones impact|amod|END_ENTITY	The separate and combined impact of the intestinal hormones , GIP , GLP-1 , and GLP-2 , on glucagon secretion in type 2 diabetes .
21864749	0	GIP	24,27	GLP-1	17,22	GIP	GLP-1	2695	100125288	Gene	Gene	DPP4|appos|START_ENTITY DPP4|compound|END_ENTITY	Incretin effect : GLP-1 , GIP , DPP4 .
22349073	0	GIP	92,95	GLP-1	126,131	GIP	GLP-1	2695	2641	Gene	Gene	glucose-dependent_insulinotropic_polypeptide|appos|START_ENTITY glucose-dependent_insulinotropic_polypeptide|appos|END_ENTITY	Fasting and oral glucose-stimulated levels of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- and glucagon-like_peptide-1 -LRB- GLP-1 -RRB- are highly familial traits .
23864340	0	GIP	32,35	GLP-1	10,15	GIP	GLP-1	2695	2641	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT .
8795084	0	GIP	6,9	GLP-1	0,5	GIP	GLP-1	2695	100125288	Gene	Gene	chimeric|compound|START_ENTITY peptides|nsubj|chimeric END_ENTITY|appos|peptides	GLP-1 / GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1 .
8795084	0	GIP	6,9	GLP-1	107,112	GIP	GLP-1	2695	100125288	Gene	Gene	chimeric|compound|START_ENTITY peptides|nsubj|chimeric peptides|xcomp|define define|nmod|interaction interaction|nmod|END_ENTITY	GLP-1 / GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1 .
8795084	3	GIP	530,533	GLP-1	524,529	GIP	GLP-1	2695	100125288	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	To characterize the domains required for interaction of the peptide ligands with their specific receptors , we performed displacement studies with various synthetic GLP-1 / GIP hybrid peptides on RINm5F_insulinoma cells .
8674860	0	GIP	42,45	Glucose-dependent_insulinotropic_peptide	0,40	GIP	Glucose-dependent insulinotropic peptide	25040(Tax:10116)	25040(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glucose-dependent_insulinotropic_peptide -LRB- GIP -RRB- gene expression in the rat salivary gland .
17890220	0	GIP	76,79	LPL	116,119	GIP	LPL	25040(Tax:10116)	24539(Tax:10116)	Gene	Gene	stimulation|appos|START_ENTITY stimulation|nmod|activity activity|appos|END_ENTITY	Resistin is a key mediator of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- stimulation of lipoprotein_lipase -LRB- LPL -RRB- activity in adipocytes .
20693566	0	GIP	0,3	LPL	101,104	GIP	LPL	2695	4023	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|trans-activation trans-activation|nmod|gene gene|compound|END_ENTITY	GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene .
20693566	0	GIP	0,3	LPL	30,33	GIP	LPL	2695	4023	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene .
21334410	0	GIP	37,40	LPL	72,75	GIP	LPL	14607(Tax:10090)	16956(Tax:10090)	Gene	Gene	analog|compound|START_ENTITY administration|nmod|analog decreases|nsubj|administration decreases|dobj|activity activity|compound|END_ENTITY	Sub-chronic administration of stable GIP analog in mice decreases serum LPL activity and body weight .
938120	0	GIP	88,91	VIP	132,135	GIP	VIP	609020(Tax:9615)	484038(Tax:9615)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide -LRB- GIP -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- .
7002390	0	GIP	55,58	gastric-inhibitory-peptide	27,53	GIP	gastric-inhibitory-peptide	2695	2695	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Autoantibodies to duodenal gastric-inhibitory-peptide -LRB- GIP -RRB- cells and to secretin -LRB- S -RRB- cells in patients with coeliac_disease , tropical_sprue and maturity-onset diabetes .
2206341	0	GIP	91,94	gastrin	47,54	GIP	gastrin	511073(Tax:9913)	280800(Tax:9913)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|compound|END_ENTITY	-LSB- Effect of hypoxia on plasma concentrations of gastrin and gastric inhibitory polypeptide -LRB- GIP -RRB- in newborn calves -RSB- .
6293900	0	GIP	53,56	gastrin	10,17	GIP	gastrin	2695	2520	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of gastrin on fasting and postprandial plasma GIP release in man .
938120	0	GIP	88,91	gastrin	15,22	GIP	gastrin	609020(Tax:9615)	100685087	Gene	Gene	polypeptide|appos|START_ENTITY secretion|nmod|polypeptide secretion|nsubj|Suppression Suppression|nmod|release release|compound|END_ENTITY	Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide -LRB- GIP -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- .
955338	0	GIP	32,35	gastrin	38,45	GIP	gastrin	2695	2520	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Gastric inhibitory polypeptide -LRB- GIP -RRB- , gastrin and insulin : response to test meal in coeliac_disease and after duodeno-pancreatectomy .
11323439	0	GIP	64,67	glucose-dependent_insulinotropic_polypeptide	18,62	GIP	glucose-dependent insulinotropic polypeptide	100753817	100753817	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	A new pathway for glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- receptor signaling : evidence for the involvement of phospholipase_A2 in GIP-stimulated insulin secretion .
16913844	0	GIP	67,70	glucose-dependent_insulinotropic_polypeptide	21,65	GIP	glucose-dependent insulinotropic polypeptide	14607(Tax:10090)	14607(Tax:10090)	Gene	Gene	analogue|appos|START_ENTITY analogue|nmod|END_ENTITY	A stable analogue of glucose-dependent_insulinotropic_polypeptide , GIP -LRB- LysPAL16 -RRB- , enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones .
20483270	0	GIP	74,77	glucose-dependent_insulinotropic_polypeptide	28,72	GIP	glucose-dependent insulinotropic polypeptide	2695	2695	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evolution of the vertebrate glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- gene .
20621665	0	GIP	75,78	glucose-dependent_insulinotropic_polypeptide	29,73	GIP	glucose-dependent insulinotropic polypeptide	2695	2695	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evolutionary conservation of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- gene regulation and the enteroinsular axis .
21146561	0	GIP	61,64	glucose-dependent_insulinotropic_polypeptide	15,59	GIP	glucose-dependent insulinotropic polypeptide	25040(Tax:10116)	25040(Tax:10116)	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- during cold acclimation .
8188305	0	GIP	62,65	glucose-dependent_insulinotropic_polypeptide	16,60	GIP	glucose-dependent insulinotropic polypeptide	2695	2695	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- to a gene cluster on chromosome 17q .
9279024	0	GIP	56,59	glucose-dependent_insulinotropic_polypeptide	10,54	GIP	glucose-dependent insulinotropic polypeptide	2695	2695	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- on insulin response to glucose in acromegalics .
9820111	0	GIP	72,75	glucose-dependent_insulinotropic_polypeptide	26,70	GIP	glucose-dependent insulinotropic polypeptide	2695	2695	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Clinical significance of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- -RSB- .
15459234	0	GIPC	62,66	CD93	0,4	GIPC	CD93	10755	22918	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	CD93 interacts with the PDZ domain-containing adaptor protein GIPC : implications in the modulation of phagocytosis .
15356268	0	GIPC	0,4	GAIP	14,18	GIPC	GAIP	10755	10287	Gene	Gene	recruits|compound|START_ENTITY END_ENTITY|nsubj|recruits	GIPC recruits GAIP -LRB- RGS19 -RRB- to attenuate dopamine_D2_receptor signaling .
20206441	0	GIPC	0,4	IGF-1R	136,142	GIPC	IGF-1R	10755	3480	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	GIPC mediates the generation of reactive oxygen species and the regulation of cancer cell proliferation by insulin-like_growth_factor-1 / IGF-1R signaling .
20634288	0	GIPC1	0,5	MyoGEF	21,27	GIPC1	MyoGEF	10755	55200	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GIPC1 interacts with MyoGEF and promotes MDA-MB-231_breast_cancer cell invasion .
19175293	0	GIPC1	13,18	Neuropilin-1	0,12	GIPC1	Neuropilin-1	67903(Tax:10090)	18186(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|parataxis|regulates	Neuropilin-1 / GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells .
26642437	0	GIPR	11,15	TCF1	0,4	GIPR	TCF1	381853(Tax:10090)	21414(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	TCF1 links GIPR signaling to the control of beta cell function and survival .
23002036	0	GIPR	105,109	glucose-dependent_insulinotropic_polypeptide_receptor	50,103	GIPR	glucose-dependent insulinotropic polypeptide receptor	381853(Tax:10090)	381853(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Resistin knockout mice exhibit impaired adipocyte glucose-dependent_insulinotropic_polypeptide_receptor -LRB- GIPR -RRB- expression .
14499479	0	GIR	103,106	glucocorticoid-induced_receptor	70,101	GIR	glucocorticoid-induced receptor	14608(Tax:10090)	14608(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Acute oral dexamethasone administration reduces levels of orphan GPCR glucocorticoid-induced_receptor -LRB- GIR -RRB- mRNA in rodent brain : potential role in HPA-axis function .
8088798	0	GIRK1	63,68	KCNJ3	76,81	GIRK1	KCNJ3	3760	3760	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Human G-protein-coupled inwardly rectifying potassium channel -LRB- GIRK1 -RRB- gene -LRB- KCNJ3 -RRB- : localization to chromosome 2 and identification of a simple tandem repeat polymorphism .
19756153	0	GIRK2	27,32	KCNJ6	20,25	GIRK2	KCNJ6	3763	3763	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between KCNJ6 -LRB- GIRK2 -RRB- gene polymorphisms and postoperative analgesic requirements after major abdominal surgery .
23994450	0	GIRK2	28,33	KCNJ6	21,26	GIRK2	KCNJ6	3763	3763	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations between KCNJ6 -LRB- GIRK2 -RRB- gene polymorphisms and pain-related phenotypes .
18643869	0	GISP	0,4	TSG101	16,22	GISP	TSG101	83998	7251	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation .
24764294	0	GIT1	119,123	G-protein-coupled_receptor_kinase-interacting_protein_1	62,117	GIT1	G-protein-coupled receptor kinase-interacting protein 1	28964	28964	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- is activated through G-protein-coupled_receptor_kinase-interacting_protein_1 -LRB- GIT1 -RRB- tyrosine phosphorylation and Src protein .
18292392	0	GIT1	0,4	HDAC5	14,19	GIT1	HDAC5	28964	10014	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	GIT1 mediates HDAC5 activation by angiotensin_II in vascular smooth muscle cells .
12153727	0	GIT1	21,25	Hic-5	0,5	GIT1	Hic-5	28964	7041	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Hic-5 interacts with GIT1 with a different binding mode from paxillin .
14523024	0	GIT1	0,4	angiotensin_II	66,80	GIT1	angiotensin II	28964	183	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin_II and epidermal growth factor .
14701758	0	GIT1	0,4	angiotensin_II	98,112	GIT1	angiotensin II	28964	183	Gene	Gene	functions|nummod|START_ENTITY signal-regulated|nsubj|functions signal-regulated|nmod|END_ENTITY	GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin_II and epidermal_growth_factor .
18292392	0	GIT1	0,4	angiotensin_II	34,48	GIT1	angiotensin II	28964	183	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	GIT1 mediates HDAC5 activation by angiotensin_II in vascular smooth muscle cells .
11812990	0	GITR	56,60	CD25	15,19	GITR	CD25	21936(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY CD4|dep|cells CD4|compound|END_ENTITY	Stimulation of CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells through GITR breaks immunological self-tolerance .
17391121	0	GITR	0,4	CD25	53,57	GITR	CD25	21936(Tax:10090)	16184(Tax:10090)	Gene	Gene	blocks|amod|START_ENTITY allograft|nsubj|blocks allograft|nmod|cells cells|compound|END_ENTITY	GITR ligation blocks allograft protection by induced CD25 + CD4 + regulatory T cells without enhancing effector T-cell function .
20139172	0	GITR	0,4	CD25	84,88	GITR	CD25	21936(Tax:10090)	16184(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY enhances|nsubj|engagement enhances|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
21052566	0	GITR	46,50	CD25	115,119	GITR	CD25	8784	3669	Gene	Gene	Glucocorticoid_induced_TNFR-related_protein|appos|START_ENTITY Glucocorticoid_induced_TNFR-related_protein|dep|expansion expansion|nmod|subset subset|compound|END_ENTITY	-LSB- Glucocorticoid_induced_TNFR-related_protein -LRB- GITR -RRB- as marker of human regulatory T cells : expansion of the GITR -LRB- + -RRB- CD25 cell subset in patients with systemic_lupus_erythematosus -RSB- .
21557210	0	GITR	17,21	CD25	7,11	GITR	CD25	8784	3559	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
25256257	0	GITR	24,28	CD25	31,35	GITR	CD25	8784	3559	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Expansion of regulatory GITR + CD25 Low / - CD4 + T cells in systemic_lupus_erythematosus patients .
15249593	0	GITR	0,4	CD4	59,62	GITR	CD4	8784	920	Gene	Gene	activation|amod|START_ENTITY induces|nsubj|activation induces|dobj|effect effect|nmod|END_ENTITY	GITR activation induces an opposite effect on alloreactive CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells in graft-versus-host_disease .
17391121	0	GITR	0,4	CD4	58,61	GITR	CD4	21936(Tax:10090)	12504(Tax:10090)	Gene	Gene	blocks|amod|START_ENTITY allograft|nsubj|blocks allograft|nmod|cells cells|compound|END_ENTITY	GITR ligation blocks allograft protection by induced CD25 + CD4 + regulatory T cells without enhancing effector T-cell function .
18930767	0	GITR	63,67	CD4	21,24	GITR	CD4	21936(Tax:10090)	12504(Tax:10090)	Gene	Gene	molecules|amod|START_ENTITY mediated|nmod|molecules mediated|nmod|expansion expansion|nmod|+ +|compound|END_ENTITY	In vivo expansion of CD4 + Foxp3 + regulatory T cells mediated by GITR molecules .
19417739	0	GITR	97,101	CD4	46,49	GITR	CD4	21936(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY transfer|nmod|ligation transfer|nsubj|immunity immunity|nmod|T-cell T-cell|compound|END_ENTITY	Therapeutic immunity by adoptive_tumor-primed CD4 -LRB- + -RRB- T-cell transfer in combination with in vivo GITR ligation .
20139172	0	GITR	0,4	CD4	80,83	GITR	CD4	21936(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY enhances|nsubj|engagement enhances|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
21557210	0	GITR	17,21	CD4	0,3	GITR	CD4	8784	920	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
21557210	0	GITR	17,21	CD4	46,49	GITR	CD4	8784	920	Gene	Gene	cells|compound|START_ENTITY cells|dep|population population|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- low -RRB- GITR -LRB- + -RRB- cells : a novel human CD4 -LRB- + -RRB- T-cell population with regulatory activity .
22317750	0	GITR	61,65	CD4	40,43	GITR	CD4	21936(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|amod|START_ENTITY T|nsubj|+ T|nsubj|function function|nmod|CD25 CD25|compound|END_ENTITY	Increased immunosuppressive function of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- GITR + T regulatory cells from NFATc2 -LRB- -LRB- - / - -RRB- -RRB- mice controls allergen-induced experimental asthma .
25256257	0	GITR	24,28	CD4	42,45	GITR	CD4	8784	920	Gene	Gene	/|compound|START_ENTITY Expansion|nmod|/ Expansion|dep|cells cells|nummod|END_ENTITY	Expansion of regulatory GITR + CD25 Low / - CD4 + T cells in systemic_lupus_erythematosus patients .
20139172	0	GITR	0,4	FoxP3	89,94	GITR	FoxP3	21936(Tax:10090)	20371(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY enhances|nsubj|engagement enhances|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	GITR engagement preferentially enhances proliferation of functionally competent CD4 + CD25 + FoxP3 + regulatory T cells .
18930767	0	GITR	63,67	Foxp3	25,30	GITR	Foxp3	21936(Tax:10090)	20371(Tax:10090)	Gene	Gene	molecules|amod|START_ENTITY mediated|nmod|molecules mediated|nmod|expansion expansion|nmod|+ +|compound|END_ENTITY	In vivo expansion of CD4 + Foxp3 + regulatory T cells mediated by GITR molecules .
20936139	0	GITR	37,41	Glucocorticoid-induced_TNFR-related	0,35	GITR	Glucocorticoid-induced TNFR-related	8784	8784	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Glucocorticoid-induced_TNFR-related -LRB- GITR -RRB- protein and its ligand in antitumor immunity : functional role and therapeutic modulation .
16285015	0	GITR	52,56	Glucocorticoid-induced_TNFR_family-related_protein	0,50	GITR	Glucocorticoid-induced TNFR family-related protein	21936(Tax:10090)	21936(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Glucocorticoid-induced_TNFR_family-related_protein -LRB- GITR -RRB- activation exacerbates murine asthma and collagen-induced arthritis .
21175417	0	GITR_ligand	63,74	glucocorticoid-induced_TNFR-related_protein	12,55	GITR ligand	glucocorticoid-induced TNFR-related protein	8995	8784	Gene	Gene	pathway|compound|START_ENTITY Role|dep|pathway Role|nmod|END_ENTITY	Role of the glucocorticoid-induced_TNFR-related_protein -LRB- GITR -RRB- - GITR_ligand pathway in innate and adaptive immunity .
20375327	0	GJA1	55,59	connexin43	43,53	GJA1	connexin43	2697	2697	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of gap junction protein connexin43 -LRB- GJA1 -RRB- in the human retina and optic nerve .
9184001	0	GJA1	41,45	connexin43	24,34	GJA1	connexin43	2697	2697	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human connexin43 gene , GJA1 , to chromosome 6q22 .3 .
17401374	0	GJA1	91,95	miR-1	29,34	GJA1	miR-1	24392(Tax:10116)	100314077(Tax:10116)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 .
15448617	0	GJA3	20,24	connexin46	8,18	GJA3	connexin46	2700	2700	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A novel connexin46 -LRB- GJA3 -RRB- mutation in autosomal dominant congenital nuclear pulverulent cataract .
21552498	0	GJA3	24,28	connexin46	30,40	GJA3	connexin46	2700	2700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the GJA3 -LRB- connexin46 -RRB- gene is associated with autosomal dominant congenital_nuclear_cataract in a Chinese family .
22312188	0	GJA3	51,55	connexin46	39,49	GJA3	connexin46	2700	2700	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Coralliform cataract caused by a novel connexin46 -LRB- GJA3 -RRB- mutation in a Chinese family .
16885921	0	GJA3	42,46	connexin_46	24,35	GJA3	connexin 46	2700	2700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the connexin_46 gene -LRB- GJA3 -RRB- causes autosomal dominant zonular pulverulent cataract in a Hispanic family .
17615540	0	GJA3	76,80	connexin_46	63,74	GJA3	connexin 46	2700	2700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel `` pearl box '' cataract associated with a mutation in the connexin_46 -LRB- GJA3 -RRB- gene .
17893674	0	GJA3	37,41	connexin_46	24,35	GJA3	connexin 46	2700	2700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the connexin_46 -LRB- GJA3 -RRB- gene associated with autosomal dominant congenital_cataract in an Indian family .
20431721	0	GJA3	123,127	connexin_46	105,116	GJA3	connexin 46	2700	2700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of congenital_cataract in a Chinese family identified a novel missense mutation in the connexin_46 gene -LRB- GJA3 -RRB- .
21647269	0	GJA3	37,41	connexin_46	24,35	GJA3	connexin 46	2700	2700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the connexin_46 -LRB- GJA3 -RRB- gene associated with congenital_cataract in a Chinese pedigree .
21254920	0	GJA7	26,30	Cx45	32,36	GJA7	Cx45	10052	10052	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation screening of the GJA7 -LRB- Cx45 -RRB- gene in a large international series of probands with nonsyndromic_hearing_impairment .
9497259	0	GJA8	50,54	connexin50	33,43	GJA8	connexin50	2703	2703	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A missense mutation in the human connexin50 gene -LRB- GJA8 -RRB- underlies autosomal dominant `` zonular pulverulent '' cataract , on chromosome 1q .
18334966	0	GJA8	21,25	connexin_50	8,19	GJA8	connexin 50	2703	2703	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A novel connexin_50 -LRB- GJA8 -RRB- mutation in a Chinese family with a dominant congenital pulverulent nuclear cataract .
20597646	0	GJA8	42,46	connexin_50	24,35	GJA8	connexin 50	2703	2703	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the connexin_50 gene -LRB- GJA8 -RRB- associated with autosomal_dominant_congenital_nuclear_cataract in a Chinese family .
17601931	0	GJA8	46,50	gap_junction_protein_alpha_8	16,44	GJA8	gap junction protein alpha 8	2703	2703	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation of the gap_junction_protein_alpha_8 -LRB- GJA8 -RRB- gene causes autosomal recessive cataract .
21720542	0	GJA8	46,50	gap_junction_protein_alpha_8	16,44	GJA8	gap junction protein alpha 8	2703	2703	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation of the gap_junction_protein_alpha_8 -LRB- GJA8 -RRB- gene causes autosomal recessive cataract .
15468313	0	GJB1	97,101	connexin_32	103,114	GJB1	connexin 32	2705	2705	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	X-linked_Charcot-Marie-Tooth_disease : phenotypic expression of a novel mutation Ile127Ser in the GJB1 -LRB- connexin_32 -RRB- gene .
23073770	0	GJB2	14,18	CX26	20,24	GJB2	CX26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prevalence of GJB2 -LRB- CX26 -RRB- gene mutations in south Iranian patients with autosomal_recessive_nonsyndromic_sensorineural_hearing_loss .
12820703	0	GJB2	55,59	Connexin-26	61,72	GJB2	Connexin-26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic laboratory practices related to testing of the GJB2 -LRB- Connexin-26 -RRB- gene in the United States in 1999 and 2000 .
14979964	0	GJB2	61,65	Connexin-26	48,59	GJB2	Connexin-26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hearing_loss associated with 35delG mutation in Connexin-26 -LRB- GJB2 -RRB- gene : audiogram analysis .
20407643	0	GJB2	24,28	Connexin-26	30,41	GJB2	Connexin-26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Absence of mutations in GJB2 -LRB- Connexin-26 -RRB- gene in an ethnic group of southwest Iran .
22369226	0	GJB2	0,4	Connexin-26	6,17	GJB2	Connexin-26	2706	2706	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	GJB2 -LRB- Connexin-26 -RRB- mutations are not frequent among hearing_impaired patients in east Greenland .
12522692	0	GJB2	18,22	Connexin26	0,10	GJB2	Connexin26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Connexin26 gene -LRB- GJB2 -RRB- : prevalence of mutations in the Chinese population .
11746015	0	GJB2	18,22	Connexin_26	0,11	GJB2	Connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Connexin_26 gene -LRB- GJB2 -RRB- mutation modulates the severity of hearing_loss associated with the 1555A -- > G mitochondrial mutation .
18950394	0	GJB2	12,16	Connexin_26	24,35	GJB2	Connexin 26	2706	2706	Gene	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	A report of GJB2 -LRB- N14K -RRB- Connexin_26 mutation in two patients -- a new subtype of KID_syndrome ?
25298064	0	GJB2	38,42	Connexin_26	44,55	GJB2	Connexin 26	2706	2706	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Electroporation Transiently Decreases GJB2 -LRB- Connexin_26 -RRB- Expression in B16/BL6 Melanoma Cell Line .
26088551	0	GJB2	108,112	Connexin_26	114,125	GJB2	Connexin 26	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Non-syndromic_hearing_loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 -LRB- Connexin_26 -RRB- gene .
15253766	0	GJB2	45,49	Cx26	51,55	GJB2	Cx26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Spectrum and frequencies of mutations in the GJB2 -LRB- Cx26 -RRB- gene among 156 Czech patients with pre-lingual_deafness .
19027181	0	GJB2	25,29	Cx26	36,40	GJB2	Cx26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular studies in the GJB2 gene -LRB- Cx26 -RRB- among a deaf population from Bogot , Colombia : results of a screening program .
22172221	0	GJB2	12,16	Cx26	18,22	GJB2	Cx26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Spectrum of GJB2 -LRB- Cx26 -RRB- gene mutations in Iranian Azeri patients with nonsyndromic autosomal recessive hearing_loss .
22649694	0	GJB2	107,111	Cx26	113,117	GJB2	Cx26	2706	2706	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Haplotype Diversity and Reconstruction of Ancestral Haplotype Associated with the c. 35delG Mutation in the GJB2 -LRB- Cx26 -RRB- Gene among the Volgo-Ural Populations of Russia .
21055240	0	GJB2	33,37	GJB3	39,43	GJB2	GJB3	2706	2707	Gene	Gene	Study|appos|START_ENTITY END_ENTITY|nsubj|Study	-LSB- Study of mtDNA 12S rRNA A1555G , GJB2 , GJB3 gene mutation in Uighur and Han people with hereditary_nonsyndromic_hearing_loss in Xinjiang -RSB- .
15479191	0	GJB2	60,64	connexin-26	47,58	GJB2	connexin-26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High prevalence of V37I genetic variant in the connexin-26 -LRB- GJB2 -RRB- gene among non-syndromic_hearing-impaired and control Thai individuals .
17313762	0	GJB2	33,37	connexin-26	20,31	GJB2	connexin-26	2706	2706	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	-LSB- High prevalence of connexin-26 -LRB- GJB2 -RRB- mutation in cochlear implant recipients -RSB- .
10204859	0	GJB2	100,104	connexin_26	87,98	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allele specific oligonucleotide analysis of the common deafness mutation 35delG in the connexin_26 -LRB- GJB2 -RRB- gene .
10607953	0	GJB2	41,45	connexin_26	23,34	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations in the connexin_26 gene -LRB- GJB2 -RRB- responsible for childhood deafness in the Japanese population .
10633133	0	GJB2	28,32	connexin_26	10,21	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prevalent connexin_26 gene -LRB- GJB2 -RRB- mutations in Japanese .
10874298	0	GJB2	25,29	connexin_26	31,42	GJB2	connexin 26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the GJB2 -LRB- connexin_26 -RRB- gene by DGGE in Greek patients with sensorineural_deafness .
10982180	0	GJB2	70,74	connexin_26	76,87	GJB2	connexin 26	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular basis of childhood_deafness resulting from mutations in the GJB2 -LRB- connexin_26 -RRB- gene .
11162081	0	GJB2	37,41	connexin_26	43,54	GJB2	connexin 26	2706	2706	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	PCR test for diagnosis of the common GJB2 -LRB- connexin_26 -RRB- 35delG mutation on dried blood spots and determination of the carrier frequency in France .
11698809	0	GJB2	0,4	connexin_26	6,17	GJB2	connexin 26	2706	2706	Gene	Gene	mutations|amod|START_ENTITY mutations|amod|END_ENTITY	GJB2 -LRB- connexin_26 -RRB- mutations and childhood deafness in Thailand .
12081719	0	GJB2	41,45	connexin_26	47,58	GJB2	connexin 26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Deafness resulting from mutations in the GJB2 -LRB- connexin_26 -RRB- gene in Brazilian patients .
12792423	0	GJB2	38,42	connexin_26	25,36	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation spectrum of the connexin_26 -LRB- GJB2 -RRB- gene in Taiwanese patients with prelingual_deafness .
12910486	0	GJB2	110,114	connexin_26	97,108	GJB2	connexin 26	2706	2706	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Use of a multiplex PCR/sequencing strategy to detect both connexin_30 -LRB- GJB6 -RRB- 342 kb deletion and connexin_26 -LRB- GJB2 -RRB- mutations in cases of childhood deafness .
14985372	0	GJB2	37,41	connexin_26	43,54	GJB2	connexin 26	2706	2706	Gene	Gene	correlation|nmod|START_ENTITY correlation|appos|END_ENTITY	A genotype-phenotype correlation for GJB2 -LRB- connexin_26 -RRB- deafness .
15700112	0	GJB2	35,39	connexin_26	41,52	GJB2	connexin 26	2706	2706	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Clinical features of patients with GJB2 -LRB- connexin_26 -RRB- mutations : severity of hearing_loss is correlated with genotypes and protein expression patterns .
15832357	0	GJB2	0,4	connexin_26	6,17	GJB2	connexin 26	2706	2706	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	GJB2 -LRB- connexin_26 -RRB- mutations are not a major cause of hearing_loss in the Indonesian population .
15857182	0	GJB2	45,49	connexin_26	27,38	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 35delG mutation in the connexin_26 gene -LRB- GJB2 -RRB- associated with congenital_deafness : European carrier frequencies and evidence for its origin in ancient Greece .
15954104	0	GJB2	25,29	connexin_26	31,42	GJB2	connexin 26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the GJB2 -LRB- connexin_26 -RRB- gene in Egypt .
19491791	0	GJB2	100,104	connexin_26	106,117	GJB2	connexin 26	2706	2706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Cochlear implantation in a child with congenital sensorineural_deafness due to 35_DELG mutation in GJB2 -LRB- connexin_26 -RRB- gene -RSB- .
19707039	0	GJB2	36,40	connexin_26	23,34	GJB2	connexin 26	2706	2706	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	High prevalence of the connexin_26 -LRB- GJB2 -RRB- mutation in Chinese_cochlear implant recipients .
19902103	0	GJB2	119,123	connexin_26	101,112	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ultrastructure of the hair in genetic prelingual_deafness associated with the 35delG mutation in the connexin_26 gene -LRB- GJB2 -RRB- .
20846357	0	GJB2	42,46	connexin_26	24,35	GJB2	connexin 26	2706	2706	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	A novel mutation in the connexin_26 gene -LRB- GJB2 -RRB- in a child with clinical and histological features of keratitis-ichthyosis-deafness -LRB- KID -RRB- syndrome .
22567861	0	GJB2	29,33	connexin_26	16,27	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Changes in the connexin_26 -LRB- GJB2 -RRB- gene in Russian patients with hearing_disorders : results of long-term molecular diagnostics of hereditary_nonsyndromic_deafness -RSB- .
26444850	0	GJB2	26,30	connexin_26	13,24	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations of connexin_26 -LRB- GJB2 -RRB- gene in a Chinese keratitis-ichthyosis-deafness_syndrome patient with squamous_cell_carcinoma .
9529365	0	GJB2	41,45	connexin_26	23,34	GJB2	connexin 26	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations in the connexin_26 gene -LRB- GJB2 -RRB- that cause autosomal recessive -LRB- DFNB1 -RRB- hearing_loss .
24503448	0	GJB2	89,93	gap_junction_beta_2	68,87	GJB2	gap junction beta 2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hearing_loss associated with an unusual mutation combination in the gap_junction_beta_2 -LRB- GJB2 -RRB- gene in a Chinese family .
12630965	0	GJB3	34,38	Connexin_31	21,32	GJB3	Connexin 31	2707	2707	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Mutation analysis of Connexin_31 -LRB- GJB3 -RRB- in sporadic non-syndromic_hearing_impairment .
21055240	0	GJB3	39,43	GJB2	33,37	GJB3	GJB2	2707	2706	Gene	Gene	START_ENTITY|nsubj|Study Study|appos|END_ENTITY	-LSB- Study of mtDNA 12S rRNA A1555G , GJB2 , GJB3 gene mutation in Uighur and Han people with hereditary_nonsyndromic_hearing_loss in Xinjiang -RSB- .
10790215	0	GJB3	105,109	connexin31	93,103	GJB3	connexin31	2707	2707	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of seven novel SNPS -LRB- five nucleotide and two amino_acid substitutions -RRB- in the connexin31 -LRB- GJB3 -RRB- gene .
15140211	0	GJB6	70,74	Cx30	59,63	GJB6	Cx30	10804	10804	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Genetic heterogeneity of KID_syndrome : identification of a Cx30 gene -LRB- GJB6 -RRB- mutation in a patient with KID_syndrome and congenital atrichia .
23219093	0	GJB6	0,4	p63	90,93	GJB6	p63	10804	8626	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	GJB6 , of which mutations underlie Clouston_syndrome , is a potential direct target gene of p63 .
21041448	0	GKAP	11,15	Dlg1	0,4	GKAP	Dlg1	9229	1739	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Dlg1 binds GKAP to control dynein association with microtubules , centrosome positioning , and cell polarity .
11060025	0	GKAP	54,58	SAP97	37,42	GKAP	SAP97	9229	1739	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Intramolecular interactions regulate SAP97 binding to GKAP .
25586176	0	GKAP42	52,58	cGMP-dependent_Kinase	82,103	GKAP42	cGMP-dependent Kinase	80318	5592	Gene	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Tumor Necrosis Factor -LRB- TNF -RRB- - a-induced Repression of GKAP42 Protein Levels through cGMP-dependent_Kinase -LRB- cGK -RRB- - Ia Causes Insulin Resistance in 3T3-L1 Adipocytes .
22002164	0	GLA	30,33	TLR4	16,20	GLA	TLR4	11605(Tax:10090)	21898(Tax:10090)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A new synthetic TLR4 agonist , GLA , allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo .
6323102	0	GLA	46,49	alpha-galactosidase	25,44	GLA	alpha-galactosidase	2717	2717	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Regional localization of alpha-galactosidase -LRB- GLA -RRB- to Xpter -- q22 , hexosaminidase_B -LRB- HEXB -RRB- to 5q13 -- qter , and arylsulfatase_B -LRB- ARSB -RRB- to 5pter -- q13 .
22307442	0	GLA	8,11	glucose-6-phosphate_dehydrogenase	44,77	GLA	glucose-6-phosphate dehydrogenase	2717	2539	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	A novel GLA mutation in a Fabry family with glucose-6-phosphate_dehydrogenase deficiency .
21448920	0	GLAST	15,20	BDNF	0,4	GLAST	BDNF	20512(Tax:10090)	12064(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BDNF regulates GLAST and glutamine_synthetase in mouse retinal M ller cells .
16163265	0	GLAST	120,125	GDNF	5,9	GLAST	GDNF	20512(Tax:10090)	14573(Tax:10090)	Gene	Gene	exert|nmod|START_ENTITY exert|nsubj|END_ENTITY	Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST ?
26893639	0	GLAST	100,105	GLT-1	94,99	GLAST	GLT-1	29483(Tax:10116)	29482(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Effects of erythropoietin preconditioning on rat cerebral_ischemia-reperfusion injury and the GLT-1 / GLAST pathway .
23200831	0	GLAST	94,99	NHERF1	20,26	GLAST	NHERF1	6507	9368	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST .
14723703	0	GLAST	49,54	Sept2	17,22	GLAST	Sept2	6507	4735	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Mammalian septin Sept2 modulates the activity of GLAST , a glutamate transporter in astrocytes .
26327163	0	GLAST	83,88	basic_fibroblast_growth_factor	93,123	GLAST	basic fibroblast growth factor	29483(Tax:10116)	54250(Tax:10116)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Stimulation of a7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic_fibroblast_growth_factor production in cultured cortical microglia .
10416860	0	GLAST	45,50	glutamate-aspartate_transporter	12,43	GLAST	glutamate-aspartate transporter	29483(Tax:10116)	29483(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Increase in glutamate-aspartate_transporter -LRB- GLAST -RRB- mRNA during kanamycin-induced cochlear insult in rats .
10812209	0	GLAST	45,50	glutamate_transporter	22,43	GLAST	glutamate transporter	29483(Tax:10116)	29483(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Effects of ammonia on glutamate_transporter -LRB- GLAST -RRB- protein and mRNA in cultured rat cortical astrocytes .
15509898	0	GLAST	81,86	glutamate_transporter	46,67	GLAST	glutamate transporter	29483(Tax:10116)	29483(Tax:10116)	Gene	Gene	expressions|appos|START_ENTITY expressions|compound|END_ENTITY	Prenatal cannabinoid exposure down - regulates glutamate_transporter expressions -LRB- GLAST and EAAC1 -RRB- in the rat cerebellum .
10320784	0	GLC1A	86,91	MYOC	80,84	GLC1A	MYOC	4653	4653	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression pattern and in situ localization of the mouse homologue of the human MYOC -LRB- GLC1A -RRB- gene in adult brain .
11558822	0	GLC3A	104,109	CYP1B1	111,117	GLC3A	CYP1B1	1545	1545	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Primary congenital_glaucoma : three case reports on novel mutations and combinations of mutations in the GLC3A -LRB- CYP1B1 -RRB- gene .
12567107	0	GLC3A	137,142	CYP1B1	144,150	GLC3A	CYP1B1	1545	1545	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Primary congenital_glaucoma : a novel single-nucleotide deletion and varying phenotypic expression for the 1,546-1 ,555 dup mutation in the GLC3A -LRB- CYP1B1 -RRB- gene in 2 families of different ethnic origin .
12736207	0	GLD-1	82,87	Notch	41,46	GLD-1	Notch	172532(Tax:6239)	176282(Tax:6239)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Translational repression of a C. _ elegans Notch mRNA by the STAR/KH domain protein GLD-1 .
17699606	0	GLH-1	0,5	KGB-1	66,71	GLH-1	KGB-1	172414(Tax:6239)	176866(Tax:6239)	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	GLH-1 , the C. _ elegans P granule protein , is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5 .
19219074	0	GLI	75,78	JUN	58,61	GLI	JUN	2735	3725	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes .
24366538	0	GLI1	0,4	C-JUN	17,22	GLI1	C-JUN	2735	3725	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	GLI1 upregulates C-JUN through a specific 130-kDa isoform .
22110720	0	GLI1	48,52	DNMT1	14,19	GLI1	DNMT1	2735	1786	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic_cancer .
23185371	0	GLI1	25,29	TGFb1	39,44	GLI1	TGFb1	2735	7040	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	The transcription factor GLI1 mediates TGFb1 driven EMT in hepatocellular_carcinoma via a SNAI1-dependent mechanism .
25252859	0	GLI1	54,58	glioma-associated_oncogene_homolog_1	16,52	GLI1	glioma-associated oncogene homolog 1	2735	2735	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Significance of glioma-associated_oncogene_homolog_1 -LRB- GLI1 -RRB- expression in claudin-low breast_cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells -LRB- NF B -RRB- pathway .
23436775	0	GLI1	0,4	neuropilin-2	23,35	GLI1	neuropilin-2	2735	8828	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	GLI1 regulates a novel neuropilin-2 / a6b1 integrin based autocrine pathway that contributes to breast_cancer initiation .
19556240	0	GLI1	42,46	osteopontin	108,119	GLI1	osteopontin	14632(Tax:10090)	20750(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin .
22859956	0	GLI2	0,4	CD4	31,34	GLI2	CD4	2736	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|compound|END_ENTITY	GLI2 regulates TGF-b1 in human CD4 + T cells : implications in cancer and HIV pathogenesis .
22859956	0	GLI2	0,4	TGF-b1	15,21	GLI2	TGF-b1	2736	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GLI2 regulates TGF-b1 in human CD4 + T cells : implications in cancer and HIV pathogenesis .
23890107	0	GLI2	0,4	ZEB1	21,25	GLI2	ZEB1	2736	6935	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells .
12435361	0	GLI3	6,10	Fgf8	21,25	GLI3	Fgf8	14634(Tax:10090)	14179(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube , face , and limb bud .
26755652	0	GLI3	79,83	MiRNA-133b	0,10	GLI3	MiRNA-133b	2737	442890	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3 .
26375121	0	GLIAL-DERIVED_NEUROTROPHIC_FACTOR	22,55	GDNF	57,61	GLIAL-DERIVED NEUROTROPHIC FACTOR	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	PROTEIN|compound|START_ENTITY PROTEIN|appos|END_ENTITY	SCK-2 : ASSOCIATION OF GLIAL-DERIVED_NEUROTROPHIC_FACTOR -LRB- GDNF -RRB- PROTEIN EXPRESSION WITH NEURONAL DEATH IN POST-RESUSCITATION PERIOD .
21786021	0	GLIS3	38,43	neurogenin_3	59,71	GLIS3	neurogenin 3	226075(Tax:10090)	11925(Tax:10090)	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	The Kr ppel-like zinc finger protein GLIS3 transactivates neurogenin_3 for proper fetal pancreatic islet differentiation in mice .
12054566	0	GLN3	32,36	GDH1	0,4	GLN3	GDH1	856763(Tax:4932)	854557(Tax:4932)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	GDH1 expression is regulated by GLN3 , GCN4 , and HAP4 under respiratory growth .
8192431	0	GLO	14,17	Glyoxalase-I	0,12	GLO	Glyoxalase-I	2739	2739	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Glyoxalase-I -LRB- GLO -RRB- polymorphism among two endogamous populations of Andhra Pradesh , India .
986362	0	GLO	41,44	glyoxalase_I	27,39	GLO	glyoxalase I	2739	2739	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Possible assignment of the glyoxalase_I -LRB- GLO -RRB- gene to chromosome 6 using man-mouse somatic cell hybrids .
17698012	0	GLO-4	83,88	RPM-1	11,16	GLO-4	RPM-1	179306(Tax:6239)	179259(Tax:6239)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	C. _ elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1 .
26832342	0	GLP-1	88,93	ApoE	112,116	GLP-1	ApoE	14526(Tax:10090)	11816(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Alleviation of high-fat diet-induced atherosclerosis and glucose_intolerance by a novel GLP-1 fusion protein in ApoE -LRB- - / - -RRB- mice .
25379405	0	GLP-1	63,68	CREB	0,4	GLP-1	CREB	14526(Tax:10090)	12912(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse b-cells .
15911573	0	GLP-1	96,101	EGO-1	0,5	GLP-1	EGO-1	176286(Tax:6239)	172524(Tax:6239)	Gene	Gene	signaling|compound|START_ENTITY promotes|nmod|signaling promotes|nsubj|END_ENTITY	EGO-1 , a putative RNA-directed RNA polymerase , promotes germline proliferation in parallel with GLP-1 / notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in Caenorhabditis_elegans .
21635674	0	GLP-1	0,5	ERK	18,21	GLP-1	ERK	14526(Tax:10090)	26413(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	GLP-1 signals via ERK in peripheral nerve and prevents nerve_dysfunction in diabetic mice .
15183115	0	GLP-1	27,32	GIP	49,52	GLP-1	GIP	24952(Tax:10116)	25040(Tax:10116)	Gene	Gene	vitro|nmod|START_ENTITY influence|advcl|vitro influence|nsubj|END_ENTITY	Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness .
15579061	0	GLP-1	60,65	GIP	117,120	GLP-1	GIP	2641	2695	Gene	Gene	glucagon-like_peptide-1|appos|START_ENTITY glucagon-like_peptide-1|appos|END_ENTITY	Structurally modified analogues of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- and glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- as future antidiabetic agents .
21330636	0	GLP-1	52,57	GIP	0,3	GLP-1	GIP	2641	2695	Gene	Gene	effects|nmod|START_ENTITY potentiate|dobj|effects potentiate|nsubj|END_ENTITY	GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes .
21386059	0	GLP-1	66,71	GIP	61,64	GLP-1	GIP	2641	2695	Gene	Gene	impact|amod|START_ENTITY impact|nmod|hormones hormones|appos|END_ENTITY	The separate and combined impact of the intestinal hormones , GIP , GLP-1 , and GLP-2 , on glucagon secretion in type 2 diabetes .
21864749	0	GLP-1	17,22	GIP	24,27	GLP-1	GIP	100125288	2695	Gene	Gene	DPP4|compound|START_ENTITY DPP4|appos|END_ENTITY	Incretin effect : GLP-1 , GIP , DPP4 .
22349073	0	GLP-1	126,131	GIP	92,95	GLP-1	GIP	2641	2695	Gene	Gene	glucose-dependent_insulinotropic_polypeptide|appos|START_ENTITY glucose-dependent_insulinotropic_polypeptide|appos|END_ENTITY	Fasting and oral glucose-stimulated levels of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- and glucagon-like_peptide-1 -LRB- GLP-1 -RRB- are highly familial traits .
23864340	0	GLP-1	10,15	GIP	32,35	GLP-1	GIP	2641	2695	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT .
8795084	0	GLP-1	0,5	GIP	6,9	GLP-1	GIP	100125288	2695	Gene	Gene	START_ENTITY|appos|peptides peptides|nsubj|chimeric chimeric|compound|END_ENTITY	GLP-1 / GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1 .
8795084	0	GLP-1	107,112	GIP	6,9	GLP-1	GIP	100125288	2695	Gene	Gene	interaction|nmod|START_ENTITY define|nmod|interaction peptides|xcomp|define peptides|nsubj|chimeric chimeric|compound|END_ENTITY	GLP-1 / GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1 .
8795084	3	GLP-1	524,529	GIP	530,533	GLP-1	GIP	100125288	2695	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	To characterize the domains required for interaction of the peptide ligands with their specific receptors , we performed displacement studies with various synthetic GLP-1 / GIP hybrid peptides on RINm5F_insulinoma cells .
26724568	0	GLP-1	0,5	GLP-1	84,89	GLP-1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	GLP-1 is both anxiogenic and antidepressant ; divergent effects of acute and chronic GLP-1 on emotionality .
26724568	0	GLP-1	84,89	GLP-1	0,5	GLP-1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	GLP-1 is both anxiogenic and antidepressant ; divergent effects of acute and chronic GLP-1 on emotionality .
26144594	0	GLP-1	46,51	GPR119	27,33	GLP-1	GPR119	14526(Tax:10090)	236781(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells .
26683635	0	GLP-1	57,62	GPR43	43,48	GLP-1	GPR43	2641	2867	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Selective novel inverse agonists for human GPR43 augment GLP-1 secretion .
26661062	0	GLP-1	17,22	Galanin	0,7	GLP-1	Galanin	14526(Tax:10090)	14419(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells .
26279396	0	GLP-1	18,23	Ghrelin	0,7	GLP-1	Ghrelin	14526(Tax:10090)	58991(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Ghrelin regulates GLP-1 production through mTOR signaling in L cells .
17584962	0	GLP-1	25,30	Glucagon-like_peptide-1	0,23	GLP-1	Glucagon-like peptide-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats .
20835917	0	GLP-1	25,30	Glucagon-like_peptide-1	0,23	GLP-1	Glucagon-like peptide-1	2641	2641	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass .
23499806	0	GLP-1	167,172	IL-6	92,96	GLP-1	IL-6	100125288	3569	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Acute peripheral administration of synthetic human GLP-1 -LRB- 7-36 amide -RRB- decreases circulating IL-6 in obese patients with type_2_diabetes_mellitus : A potential role for GLP-1 in modulation of the diabetic pro-inflammatory state ?
23499806	0	GLP-1	51,56	IL-6	92,96	GLP-1	IL-6	100125288	3569	Gene	Gene	administration|nmod|START_ENTITY decreases|nsubj|administration decreases|xcomp|circulating circulating|dobj|END_ENTITY	Acute peripheral administration of synthetic human GLP-1 -LRB- 7-36 amide -RRB- decreases circulating IL-6 in obese patients with type_2_diabetes_mellitus : A potential role for GLP-1 in modulation of the diabetic pro-inflammatory state ?
23997935	0	GLP-1	146,151	Insulin	0,7	GLP-1	Insulin	2641	3630	Gene	Gene	role|nmod|START_ENTITY mammal|dep|role demonstrate|nmod|mammal demonstrate|nsubj|infusions infusions|compound|END_ENTITY	Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal : potential glucogenic role for GLP-1 .
25825945	0	GLP-1	22,27	Insulin	78,85	GLP-1	Insulin	2641	3630	Gene	Gene	Sensitivity|nmod|START_ENTITY Variable|nsubj|Sensitivity Variable|nmod|Sensitivity Sensitivity|compound|END_ENTITY	b-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity .
26225223	0	GLP-1	17,22	Insulin	117,124	GLP-1	Insulin	2641	3630	Gene	Gene	Analog|compound|START_ENTITY Effects|nmod|Analog Diabetes_Mellitus|nsubj|Effects Diabetes_Mellitus|nmod|Model Model|compound|END_ENTITY	The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes_Mellitus Quantified by an Integrated Glucose Insulin Model .
26908914	0	GLP-1	0,5	Insulin	23,30	GLP-1	Insulin	100125288	3630	Gene	Gene	Restores|nsubj|START_ENTITY Restores|dobj|END_ENTITY	GLP-1 Restores Altered Insulin and Glucagon Secretion_in_Posttransplantation_Diabetes .
21324568	0	GLP-1	126,131	PYY	149,152	GLP-1	PYY	2641	5697	Gene	Gene	glucagon-like_peptide-1|appos|START_ENTITY glucagon-like_peptide-1|appos|END_ENTITY	The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- and peptide_YY -LRB- PYY -RRB- .
26208278	0	GLP-1	38,43	TGR5	8,12	GLP-1	TGR5	14526(Tax:10090)	227289(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic b-Cells in Type 2 Diabetic Mice .
26208278	0	GLP-1	38,43	TGR5	8,12	GLP-1	TGR5	14526(Tax:10090)	227289(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic b-Cells in Type 2 Diabetic Mice .
26571400	0	GLP-1	0,5	TRPM4	52,57	GLP-1	TRPM4	100125288	54795	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation .
12714357	0	GLP-1	46,51	c-Fos	27,32	GLP-1	c-Fos	24952(Tax:10116)	314322(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Gastric distension induces c-Fos in medullary GLP-1 / 2-containing neurons .
14574347	0	GLP-1	47,52	glucagon-like_peptide-1	22,45	GLP-1	glucagon-like peptide-1	2641	2641	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Racial differences in glucagon-like_peptide-1 -LRB- GLP-1 -RRB- concentrations and insulin dynamics during oral glucose tolerance test in obese subjects .
17184947	0	GLP-1	73,78	glucagon-like_peptide-1	48,71	GLP-1	glucagon-like peptide-1	14526(Tax:10090)	14526(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Beneficial effects of sub-chronic activation of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors on deterioration of glucose homeostasis and insulin secretion in aging mice .
22353624	0	GLP-1	53,58	glucagon-like_peptide-1	28,51	GLP-1	glucagon-like peptide-1	2641	2641	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Comparison of plasma active glucagon-like_peptide-1 -LRB- GLP-1 -RRB- levels assayed with or without plasma extraction in non-diabetic men .
22938097	0	GLP-1	43,48	glucagon-like_peptide-1	18,41	GLP-1	glucagon-like peptide-1	2641	2641	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in neuroprotection .
3304721	0	GLP-1	51,56	glucagon-like_peptide-1	26,49	GLP-1	glucagon-like peptide-1	2641	2641	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	A large molecular form of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- immunoreactivity is co-released with glucagon from pancreas by arginine in normal subjects .
8839251	0	GLP-1	36,41	glucagon-like_peptide-1	11,34	GLP-1	glucagon-like peptide-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in RINm5F_insulinoma cells .
8863504	0	GLP-1	43,48	glucagon-like_peptide-1	18,41	GLP-1	glucagon-like peptide-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Colocalization of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors , glucose transporter GLUT-2 , and glucokinase mRNAs in rat hypothalamic cells : evidence for a role of GLP-1_receptor agonists as an inhibitory signal for food and water intake .
9094161	0	GLP-1	61,66	glucagon-like_peptide-1	36,59	GLP-1	glucagon-like peptide-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Reciprocal cellular distribution of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- immunoreactivity and GLP-1_receptor mRNA in pancreatic islets of rat .
9134052	0	GLP-1	36,41	glucagon-like_peptide-1	11,34	GLP-1	glucagon-like peptide-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- by carbohydrates in the perfused rat ileum .
11181533	0	GLP-1	48,53	glucagon-like_peptide_1	23,46	GLP-1	glucagon-like peptide 1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Insulinotropic hormone glucagon-like_peptide_1 -LRB- GLP-1 -RRB- activation of insulin gene promoter inhibited by p38_mitogen-activated_protein_kinase .
22965295	0	GLP-1	33,38	glucagon-like_peptide_1	8,31	GLP-1	glucagon-like peptide 1	2641	2641	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	A local glucagon-like_peptide_1 -LRB- GLP-1 -RRB- system in human pancreatic islets .
23909258	0	GLP-1	12,17	glucagon-like_peptide_1	19,42	GLP-1	glucagon-like peptide 1	2641	2641	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	-LSB- Effects of GLP-1 -LRB- glucagon-like_peptide_1 -RRB- on liver -RSB- .
8650968	0	GLP-1	36,41	glucagon-like_peptide_1	11,34	GLP-1	glucagon-like peptide 1	100125288	2641	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	Release of glucagon-like_peptide_1 -LRB- GLP-1 -LSB- 7-36 amide -RSB- -RRB- , gastric inhibitory polypeptide -LRB- GIP -RRB- and insulin in response to oral glucose after upper and lower intestinal resections .
25200998	0	GLP-1	76,81	glucagon-like_peptide_1_receptor	34,66	GLP-1	glucagon-like peptide 1 receptor	100125288	2740	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Role of rs6923761 gene variant in glucagon-like_peptide_1_receptor in basal GLP-1 levels , cardiovascular_risk factor and serum adipokine levels in na ve type 2 diabetic patients .
12397536	0	GLP-1	75,80	growth_hormone	10,24	GLP-1	growth hormone	24952(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone on high plasma levels of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in hypophysectomized rats .
10855533	0	GLP-1	26,31	insulin	52,59	GLP-1	insulin	2641	3630	Gene	Gene	increases|compound|START_ENTITY treatment|nmod|increases pulsatile|nsubj|treatment pulsatile|dobj|secretion secretion|compound|END_ENTITY	Short-term treatment with GLP-1 increases pulsatile insulin secretion in Type_II_diabetes with no effect on orderliness .
12475787	0	GLP-1	24,29	insulin	67,74	GLP-1	insulin	2641	3630	Gene	Gene	actions|nmod|START_ENTITY actions|nmod|process process|nmod|secretion secretion|compound|END_ENTITY	The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion .
12540611	0	GLP-1	17,22	insulin	45,52	GLP-1	insulin	2641	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The influence of GLP-1 on glucose-stimulated insulin secretion : effects on beta-cell sensitivity in type 2 and nondiabetic subjects .
20215429	0	GLP-1	21,26	insulin	30,37	GLP-1	insulin	2641	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes .
21047924	0	GLP-1	11,16	insulin	86,93	GLP-1	insulin	100125288	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|parataxis|contributions contributions|nmod|glucagon glucagon|compound|END_ENTITY	Endogenous GLP-1 regulates postprandial glycemia in humans : relative contributions of insulin , glucagon , and gastric emptying .
21645806	0	GLP-1	4,9	insulin	40,47	GLP-1	insulin	101097825	493804(Tax:9685)	Gene	Gene	mimetic|amod|START_ENTITY exenatide|amod|mimetic potentiates|nsubj|exenatide potentiates|dobj|secretion secretion|compound|END_ENTITY	The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats .
22015237	0	GLP-1	25,30	insulin	55,62	GLP-1	insulin	2641	3630	Gene	Gene	analogue|appos|START_ENTITY analogue|nmod|END_ENTITY	Glucagon-like_peptide_1 -LRB- GLP-1 -RRB- analogue combined with insulin reduces HbA1c and weight with low risk of hypoglycemia and high treatment satisfaction .
22421983	0	GLP-1	32,37	insulin	51,58	GLP-1	insulin	100125288	3630	Gene	Gene	treatment|compound|START_ENTITY effects|nmod|treatment effects|nmod|patients patients|compound|END_ENTITY	Metabolic effects of short-term GLP-1 treatment in insulin resistant heart_failure patients .
23573808	0	GLP-1	0,5	insulin	70,77	GLP-1	insulin	2641	3630	Gene	Gene	response|amod|START_ENTITY impaired|nsubjpass|response impaired|nmod|resistance resistance|compound|END_ENTITY	GLP-1 and peptide_YY secretory response after fat load is impaired by insulin resistance , impaired fasting glucose_and_type_2_diabetes in morbidly obese subjects .
23711193	0	GLP-1	116,121	insulin	80,87	GLP-1	insulin	2641	3630	Gene	Gene	analogue|compound|START_ENTITY addition|nmod|analogue Options|dep|addition Options|acl|using using|dobj|END_ENTITY	Options for prandial glucose management in type 2 diabetes patients using basal insulin : addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy .
23997935	0	GLP-1	146,151	insulin	70,77	GLP-1	insulin	2641	3630	Gene	Gene	role|nmod|START_ENTITY mammal|dep|role demonstrate|nmod|mammal demonstrate|dobj|onset onset|nmod|resistance resistance|compound|END_ENTITY	Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal : potential glucogenic role for GLP-1 .
26990378	0	GLP-1	185,190	insulin	21,28	GLP-1	insulin	100125288	3630	Gene	Gene	Study|compound|START_ENTITY BEGIN|dep|Study trial|appos|BEGIN controlled|dobj|trial effect|acl|controlled effect|acl|adding adding|dobj|degludec degludec|compound|END_ENTITY	The effect of adding insulin degludec in patients with type 2 diabetes inadequately controlled with metformin and liraglutide : a double-blind randomized controlled trial -LRB- BEGIN : ADD TO GLP-1 Study -RRB- .
27015674	0	GLP-1	37,42	insulin	97,104	GLP-1	insulin	100125288	3630	Gene	Gene	line|compound|START_ENTITY cells|nmod|line Co-culture|nmod|cells impacts|nsubj|Co-culture impacts|nmod|secretion secretion|compound|END_ENTITY	Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion , proliferation and susceptibility to cytotoxins .
10708552	0	GLP-1	33,38	leptin	10,16	GLP-1	leptin	24952(Tax:10116)	25608(Tax:10116)	Gene	Gene	peptide|compound|START_ENTITY Effect|nmod|peptide Effect|nmod|END_ENTITY	Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNA .
26037201	0	GLP-1	26,31	mTOR	11,15	GLP-1	mTOR	14526(Tax:10090)	21977(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Intestinal mTOR regulates GLP-1 production in mouse L cells .
12110536	0	GLP-1	26,31	somatostatin_receptor_subtype_5	46,77	GLP-1	somatostatin receptor subtype 5	24952(Tax:10116)	25354(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Somatostatin-28 regulates GLP-1 secretion via somatostatin_receptor_subtype_5 in rat intestinal cultures .
26330822	0	GLP-1R	34,40	Glucagon_peptide-like_1_receptor	0,32	GLP-1R	Glucagon peptide-like 1 receptor	2740	2740	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucagon_peptide-like_1_receptor -LRB- GLP-1R -RRB- expression per se : a new insight into neurodegenerative_disease ?
26196539	0	GLP-1_Receptor	18,32	ACE2	58,62	GLP-1 Receptor	ACE2	25051(Tax:10116)	302668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Activation of the GLP-1_Receptor by Liraglutide Increases ACE2 Expression , Reversing Right Ventricle Hypertrophy , and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats .
27035653	0	GLP-1_Receptor	100,114	CREB	129,133	GLP-1 Receptor	CREB	2740	1385	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Long-term Exposure of Pancreatic Beta-Cells to Palmitate Results in SREBP-1C-dependent Decreases in GLP-1_Receptor Signaling via CREB and AKT and Insulin Secretory Response .
25897187	0	GLP-1_Receptor	7,21	Insulin	47,54	GLP-1 Receptor	Insulin	2740	3630	Gene	Gene	Therapy|compound|START_ENTITY Therapy|nmod|END_ENTITY	Adding GLP-1_Receptor Agonist Therapy to Basal Insulin for Postprandial Glucose Control .
24923102	0	GLP-1_receptor	29,43	LAR	63,66	GLP-1 receptor	LAR	2740	5792	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	-LSB- Bydureon : first once weekly GLP-1_receptor agonist -LRB- exenatide LAR -RRB- -RSB- .
11738243	0	GLP-2	25,30	GLP-2_receptor	57,71	GLP-2	GLP-2 receptor	93896(Tax:10090)	93896(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The truncated metabolite GLP-2 -LRB- 3-33 -RRB- interacts with the GLP-2_receptor as a partial agonist .
16448646	0	GLP-2	45,50	glucagon-like_peptide-2	20,43	GLP-2	glucagon-like peptide-2	2641	2641	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Naturally occurring glucagon-like_peptide-2 -LRB- GLP-2 -RRB- receptors in human intestinal cell lines .
11738243	0	GLP-2_receptor	57,71	GLP-2	25,30	GLP-2 receptor	GLP-2	93896(Tax:10090)	93896(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The truncated metabolite GLP-2 -LRB- 3-33 -RRB- interacts with the GLP-2_receptor as a partial agonist .
8895391	0	GLP1-R	34,40	Glucagon-like_peptide-1_receptor	0,32	GLP1-R	Glucagon-like peptide-1 receptor	25051(Tax:10116)	25051(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Glucagon-like_peptide-1_receptor -LRB- GLP1-R -RRB- mRNA in the rat hypothalamus .
22417644	0	GLP1R	54,59	glucagon-like_peptide_1_receptor	20,52	GLP1R	glucagon-like peptide 1 receptor	428573(Tax:9031)	428573(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of glucagon-like_peptide_1_receptor -LRB- GLP1R -RRB- gene in chickens : functional analysis , tissue distribution , and identification of its transcript variants .
24906922	0	GLP2R	54,59	glucagon-like_peptide_2_receptor	20,52	GLP2R	glucagon-like peptide 2 receptor	427787(Tax:9031)	427787(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of glucagon-like_peptide_2_receptor -LRB- GLP2R -RRB- gene in chickens : functional analysis , tissue distribution , and developmental expression profile of GLP2R in embryonic intestine .
11389164	0	GLRA1	50,55	glycine_receptor_alpha1_subunit	17,48	GLRA1	glycine receptor alpha1 subunit	2741	2741	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the glycine_receptor_alpha1_subunit -LRB- GLRA1 -RRB- gene in hereditary hyperekplexia pedigrees : evidence for non-penetrance of mutation Y279C .
9676428	0	GLRB	46,50	glycine_receptor_beta_subunit	10,39	GLRB	glycine receptor beta subunit	2743	2743	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human glycine_receptor_beta_subunit gene -LRB- GLRB -RRB- : structure , refined chromosomal localization , and population polymorphism .
8838810	0	GLRX	33,37	glutaredoxin	19,31	GLRX	glutaredoxin	2745	2745	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for human glutaredoxin -LRB- GLRX -RRB- is localized to human chromosome 5q14 .
19200233	0	GLT-1	62,67	C5a	37,40	GLT-1	C5a	6506	728	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner .
24442982	0	GLT-1	41,46	CA1	71,74	GLT-1	CA1	29482(Tax:10116)	310218(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Up-regulation of neuronal and astrocytic GLT-1 mRNA in the hippocampal CA1 subfield during the induction of brain ischemic tolerance in rats .
19998491	0	GLT-1	54,59	EAAT-2	60,66	GLT-1	EAAT-2	6506	6506	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Comparative structural and functional analysis of the GLT-1 / EAAT-2 promoter from man and rat .
24277080	0	GLT-1	27,32	EAAT2	33,38	GLT-1	EAAT2	20511(Tax:10090)	20511(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|expression expression|compound|END_ENTITY	Differential regulation of GLT-1 / EAAT2 gene expression by NF-kB and N-myc in male mouse brain during postnatal development .
9771796	0	GLT-1	11,16	EAAT2	4,9	GLT-1	EAAT2	6506	6506	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The EAAT2 -LRB- GLT-1 -RRB- gene in motor_neuron_disease : absence of mutations in amyotrophic_lateral_sclerosis and a point mutation in patients with hereditary_spastic_paraplegia .
26893639	0	GLT-1	94,99	GLAST	100,105	GLT-1	GLAST	29482(Tax:10116)	29483(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Effects of erythropoietin preconditioning on rat cerebral_ischemia-reperfusion injury and the GLT-1 / GLAST pathway .
22645130	0	GLT-1	38,43	GPR30	0,5	GLT-1	GPR30	29482(Tax:10116)	171104(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes .
21426345	0	GLT-1	36,41	MAGI-1	45,51	GLT-1	MAGI-1	6506	9223	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of glutamate transporter GLT-1 by MAGI-1 .
12533722	0	GLT-1	41,46	glutamate_transporter	19,40	GLT-1	glutamate transporter	29482(Tax:10116)	29483(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Changes of retinal glutamate_transporter GLT-1 mRNA levels following optic_nerve_damage .
16026460	0	GLT-1	12,17	glutamate_transporter	29,50	GLT-1	glutamate transporter	29482(Tax:10116)	29483(Tax:10116)	Gene	Gene	subtype|compound|START_ENTITY subtype|nmod|END_ENTITY	Role of the GLT-1 subtype of glutamate_transporter in glutamate homeostasis : the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus .
21964391	0	GLT-1	16,21	glutamate_transporter	61,82	GLT-1	glutamate transporter	29482(Tax:10116)	29483(Tax:10116)	Gene	Gene	START_ENTITY|dep|form form|nmod|END_ENTITY	Exon 4-skipping GLT-1 : a new form of an abundantly expressed glutamate_transporter .
19328838	0	GLT1	73,77	EAAT2	79,84	GLT1	EAAT2	29482(Tax:10116)	29482(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The concentrations and distributions of three C-terminal variants of the GLT1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate_transporter protein in rat brain tissue suggest differential regulation .
21291866	0	GLT1	40,44	Insulin	0,7	GLT1	Insulin	6506	3630	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Insulin increases glutamate transporter GLT1 in cultured astrocytes .
19328838	0	GLT1	73,77	glutamate_transporter	94,115	GLT1	glutamate transporter	29482(Tax:10116)	29483(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The concentrations and distributions of three C-terminal variants of the GLT1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate_transporter protein in rat brain tissue suggest differential regulation .
24173238	0	GLT8D2	20,26	ApoB100	48,55	GLT8D2	ApoB100	83468	338	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Glycosyltransferase GLT8D2 positively regulates ApoB100 protein expression in hepatocytes .
18261224	0	GLTP	35,39	glycolipid_transfer_protein	6,33	GLTP	glycolipid transfer protein	51228	51228	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Human glycolipid_transfer_protein -LRB- GLTP -RRB- genes : organization , transcriptional status and evolution .
20974858	0	GLTP	40,44	glycolipid_transfer_protein	6,33	GLTP	glycolipid transfer protein	51228	51228	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human glycolipid_transfer_protein gene -LRB- GLTP -RRB- expression is regulated by Sp1 and Sp3 : involvement of the bioactive sphingolipid_ceramide .
25818168	0	GLTSCR2	0,7	nucleophosmin	45,58	GLTSCR2	nucleophosmin	29997	4869	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer .
22522597	0	GLTSCR2	18,25	p53	37,40	GLTSCR2	p53	29997	7157	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses .
26118026	0	GLUCOCORTICOID_RECEPTOR	22,45	BCL1	1,5	GLUCOCORTICOID RECEPTOR	BCL1	2908	595	Gene	Gene	GENE|compound|START_ENTITY POLYMORPHISM|nmod|GENE POLYMORPHISM|compound|END_ENTITY	-LSB- BCL1 POLYMORPHISM OF GLUCOCORTICOID_RECEPTOR GENE AND RESPIRATORY DISEASES -RSB- .
19063943	0	GLUR2/3	90,97	Neuronal_enriched_endosomal_protein_of_21_kDa	0,45	GLUR2/3	Neuronal enriched endosomal protein of 21 kDa	2891;2892	27065	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	Neuronal_enriched_endosomal_protein_of_21_kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic membrane .
2566971	0	GLUT	64,68	Hep	24,27	GLUT	Hep	6513	728489	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Stu I RFLP at the human Hep G2/erythrocyte glucose transporter -LRB- GLUT -RRB- gene locus .
10622535	0	GLUT	61,65	glucose_transporter	40,59	GLUT	glucose transporter	6513	6513	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Differential expression of facilitative glucose_transporter -LRB- GLUT -RRB- genes in primary lung_cancers and their liver metastases .
15389572	0	GLUT	58,62	glucose_transporter	37,56	GLUT	glucose transporter	6513	6513	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Molecular and cellular regulation of glucose_transporter -LRB- GLUT -RRB- proteins in cancer .
15254667	0	GLUT-1	34,40	ER-alpha	64,72	GLUT-1	ER-alpha	6513	2099	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of glucose transporter GLUT-1 and estrogen receptors ER-alpha and ER-beta in human breast_cancer .
8646755	0	GLUT-1	49,55	glucose_transporter	28,47	GLUT-1	glucose transporter	24778(Tax:10116)	6513	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Subcellular distribution of glucose_transporter -LRB- GLUT-1 -RRB- during development of the blood-brain barrier in rats .
9486290	0	GLUT-1	91,97	glucose_transporter	70,89	GLUT-1	glucose transporter	24778(Tax:10116)	24778(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Time-dependent physiological regulation of rodent and ovine placental glucose_transporter -LRB- GLUT-1 -RRB- protein .
18410529	0	GLUT-1	61,67	glucose_transporter-1	38,59	GLUT-1	glucose transporter-1	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Resistin modulates glucose uptake and glucose_transporter-1 -LRB- GLUT-1 -RRB- expression in trophoblast cells .
10736070	0	GLUT-1	56,62	glucose_transporter-1_protein	25,54	GLUT-1	glucose transporter-1 protein	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Membranous expression of glucose_transporter-1_protein -LRB- GLUT-1 -RRB- in embryonal_neoplasms of the central nervous system .
11972644	0	GLUT-1	163,169	glucose_transporter_1	140,161	GLUT-1	glucose transporter 1	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Significance of 18F-fluorodeoxyglucose positron emission tomography -LRB- FDG-PET -RRB- for detection of renal_cell_carcinoma and immunohistochemical glucose_transporter_1 -LRB- GLUT-1 -RRB- expression in the cancer .
12114701	0	GLUT-2	58,64	Glucose_Transporter-2	35,56	GLUT-2	Glucose Transporter-2	6514	6514	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Immunocytochemical Localization of Glucose_Transporter-2 -LRB- GLUT-2 -RRB- in Pancreatic_Islets_and_Islet_Cell_Tumors .
23054751	0	GLUT-3	47,53	glucose_transporter-3	24,45	GLUT-3	glucose transporter-3	6515	6515	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Progressive increase of glucose_transporter-3 -LRB- GLUT-3 -RRB- expression in estrogen-induced breast_carcinogenesis .
8897851	0	GLUT-4	67,73	glucose_transport	48,65	GLUT-4	glucose transport	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	In vivo effects of dexamethasone and sucrose on glucose_transport -LRB- GLUT-4 -RRB- protein tissue distribution .
10400647	0	GLUT1	14,19	Akt1	70,74	GLUT1	Akt1	20525(Tax:10090)	11651(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1 .
15975910	0	GLUT1	39,44	GLUT1CBP	0,8	GLUT1	GLUT1CBP	6513	10755	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	GLUT1CBP -LRB- TIP2/GIPC1 -RRB- interactions with GLUT1 and myosin_VI : evidence supporting an adapter function for GLUT1CBP .
26824929	0	GLUT1	42,47	Glucose_Transporter_1	19,40	GLUT1	Glucose Transporter 1	6513	6513	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Gene Expression of Glucose_Transporter_1 -LRB- GLUT1 -RRB- , Hexokinase_1 and Hexokinase_2 in Gastroenteropancreatic_Neuroendocrine_Tumors : Correlation with F-18-fluorodeoxyglucose Positron Emission Tomography and Cellular Proliferation .
8333327	0	GLUT1	21,26	Glucose_transporter	0,19	GLUT1	Glucose transporter	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucose_transporter -LRB- GLUT1 -RRB- expression by canine brain microvessel endothelial cells in culture : an immunocytochemical study .
20803547	0	GLUT1	20,25	Glypican_3	0,10	GLUT1	Glypican 3	6513	2719	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Glypican_3 binds to GLUT1 and decreases glucose transport activity in hepatocellular_carcinoma cells .
10942631	0	GLUT1	8,13	Igf1	28,32	GLUT1	Igf1	20512(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduced GLUT1 expression in Igf1 - / - null oocytes and follicles .
7768884	0	GLUT1	55,60	SHPTP2	29,35	GLUT1	SHPTP2	6513	5781	Gene	Gene	expression|compound|START_ENTITY roles|nmod|expression roles|nmod|END_ENTITY	Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation .
10980529	0	GLUT1	23,28	SLC2A1	30,36	GLUT1	SLC2A1	6513	6513	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Mutational analysis of GLUT1 -LRB- SLC2A1 -RRB- in Glut-1 deficiency_syndrome .
11102982	0	GLUT1	23,28	SLC2A1	30,36	GLUT1	SLC2A1	6513	6513	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Mutational analysis of GLUT1 -LRB- SLC2A1 -RRB- in glut-1 deficiency syndrome ; dong wang ; pamela kranz-eble ; darryl_C .
17489814	0	GLUT1	62,67	SLC2A1	54,60	GLUT1	SLC2A1	6513	6513	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel microdeletion in 1 -LRB- p34 .2 p34 .3 -RRB- , involving the SLC2A1 -LRB- GLUT1 -RRB- gene , and severe delayed development .
18215134	0	GLUT1	31,36	TBC1D1	14,20	GLUT1	TBC1D1	6513	23216	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes .
21613414	0	GLUT1	0,5	TSC2	46,50	GLUT1	TSC2	6513	7249	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	GLUT1 enhances mTOR activity independently of TSC2 and AMPK .
8995440	0	GLUT1	63,68	Tumor_necrosis_factor-alpha	0,27	GLUT1	Tumor necrosis factor-alpha	6513	7124	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Tumor_necrosis_factor-alpha regulation of glucose_transporter -LRB- GLUT1 -RRB- mRNA turnover .
20937822	0	GLUT1	76,81	WNK1	15,19	GLUT1	WNK1	6513	65125	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2 / USP6-BUB2-Cdc16_domain_family_member_4 -LRB- TBC1D4 -RRB- - Rab8A complex .
11231353	0	GLUT1	42,47	glucose_transporter	21,40	GLUT1	glucose transporter	6513	6513	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of the glucose_transporter -LRB- GLUT1 -RRB- gene are associated with diabetic_nephropathy .
16639702	0	GLUT1	39,44	glucose_transporter	18,37	GLUT1	glucose transporter	20525(Tax:10090)	20525(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	The regulation of glucose_transporter -LRB- GLUT1 -RRB- expression by the RNA binding protein HuR .
8995440	0	GLUT1	63,68	glucose_transporter	42,61	GLUT1	glucose transporter	6513	6513	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha regulation of glucose_transporter -LRB- GLUT1 -RRB- mRNA turnover .
9001249	0	GLUT1	85,90	glucose_transporter	64,83	GLUT1	glucose transporter	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ectopic expression of Hel-N1 , an RNA-binding protein , increases glucose_transporter -LRB- GLUT1 -RRB- expression in 3T3-L1 adipocytes .
12417042	0	GLUT1	48,53	glucose_transporter_1	25,46	GLUT1	glucose transporter 1	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical significance of glucose_transporter_1 -LRB- GLUT1 -RRB- expression in human breast_carcinoma .
8755650	2	GLUT1	70,75	glucose_transporter_1	47,68	GLUT1	glucose transporter 1	397404(Tax:9823)	397404(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Activation of the glucose_transporter_1 -LRB- GLUT1 -RRB- gene and glycolysis in LLC-PK1 cells under Ca2 + stress .
10740976	0	GLUT1	99,104	glucose_transporter_type_1	71,97	GLUT1	glucose transporter type 1	100753506	100753506	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose_transporter_type_1 -LRB- GLUT1 -RRB- translocation in Chinese_hamster_ovary -LRB- CHO -RRB- cells stably expressing fMLP or PAF receptor .
25385184	0	GLUT1	74,79	mTOR	50,54	GLUT1	mTOR	6513	21977(Tax:10090)	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation .
15936967	0	GLUT10	23,29	SLC2A10	14,21	GLUT10	SLC2A10	81031	81031	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of SLC2A10 -LRB- GLUT10 -RRB- as a candidate gene for type_2_diabetes and related traits in Finns .
16154905	0	GLUT11	39,45	SLC2A11	30,37	GLUT11	SLC2A11	66035	66035	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the human SLC2A11 -LRB- GLUT11 -RRB- gene : alternative promoter usage , function , expression , and subcellular distribution of three isoforms , and lack of mouse orthologue .
15975910	0	GLUT1CBP	0,8	GLUT1	39,44	GLUT1CBP	GLUT1	10755	6513	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	GLUT1CBP -LRB- TIP2/GIPC1 -RRB- interactions with GLUT1 and myosin_VI : evidence supporting an adapter function for GLUT1CBP .
7983778	0	GLUT2	27,32	GLUT2	60,65	GLUT2	GLUT2	6514	6514	Gene	Gene	gene|compound|START_ENTITY gene|nmod|expression expression|compound|END_ENTITY	-LSB- Organization of the human GLUT2 gene and regulation of the GLUT2 gene expression -RSB- .
7983778	0	GLUT2	60,65	GLUT2	27,32	GLUT2	GLUT2	6514	6514	Gene	Gene	expression|compound|START_ENTITY gene|nmod|expression gene|compound|END_ENTITY	-LSB- Organization of the human GLUT2 gene and regulation of the GLUT2 gene expression -RSB- .
1631055	0	GLUT2	27,32	HRAS	8,12	GLUT2	HRAS	20526(Tax:10090)	15461(Tax:10090)	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	-LSB- Val12 -RSB- HRAS downregulates GLUT2 in beta cells of transgenic_mice without affecting glucose homeostasis .
12700970	0	GLUT2	28,33	SLC2A2	19,25	GLUT2	SLC2A2	6514	6514	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No mutation in the SLC2A2 -LRB- GLUT2 -RRB- gene in a Turkish infant with Fanconi-Bickel_syndrome .
15983230	0	GLUT2	29,34	SLC2A2	21,27	GLUT2	SLC2A2	6514	6514	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the SLC2A2 -LRB- GLUT2 -RRB- gene are associated with the conversion from impaired_glucose_tolerance to type 2 diabetes : the Finnish Diabetes Prevention Study .
7593414	0	GLUT2	71,76	glucose_transporter	50,69	GLUT2	glucose transporter	6514	6514	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence variations of the pancreatic islet/liver glucose_transporter -LRB- GLUT2 -RRB- gene in Japanese subjects with noninsulin dependent diabetes_mellitus .
15482900	0	GLUT2	62,67	glucose_transporter_2	39,60	GLUT2	glucose transporter 2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of the glucose_transporter_2 -LRB- GLUT2 -RRB- in the adult rat brain .
15665515	0	GLUT2	49,54	glucose_transporter_2	26,47	GLUT2	glucose transporter 2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Insulin_receptor _ -LRB- IR -RRB- and glucose_transporter_2 -LRB- GLUT2 -RRB- proteins form a complex on the rat hepatocyte membrane .
9665105	0	GLUT2	115,120	glucose_transporter_2	92,113	GLUT2	glucose transporter 2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Short-chain fatty_acid-supplemented total parenteral nutrition alters intestinal structure , glucose_transporter_2 -LRB- GLUT2 -RRB- mRNA and protein , and proglucagon mRNA abundance in normal rats .
8674846	0	GLUT2	62,67	glucose_transporter_type_2	34,60	GLUT2	glucose transporter type 2	20526(Tax:10090)	20526(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	A 338-bp proximal fragment of the glucose_transporter_type_2 -LRB- GLUT2 -RRB- promoter drives reporter gene expression in the pancreatic islets of transgenic_mice .
11978637	0	GLUT2	87,92	p300	75,79	GLUT2	p300	6514	2033	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter .
24815515	0	GLUT3	73,78	AMP-activated_protein_kinase	41,69	GLUT3	AMP-activated protein kinase	6515	5563	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of pharmacological inhibition of AMP-activated_protein_kinase on GLUT3 expression and the development of ischemic tolerance in astrocytes .
11436180	0	GLUT3	18,23	GLUT4	74,79	GLUT3	GLUT4	6515	6517	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4 : protein in muscle from patients with acanthosis nigricans and severe insulin resistance .
18084728	0	GLUT3	87,92	GLUT4	94,99	GLUT3	GLUT4	25551(Tax:10116)	25139(Tax:10116)	Gene	Gene	GCK|appos|START_ENTITY GCK|appos|END_ENTITY	Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2 , GLUT3 , GLUT4 , GCK , and sulfonylurea_receptor-1 gene expression in the ovariectomized female rat LHA and VMH : impact of estradiol .
8006068	0	GLUT3	69,74	GLUT4	76,81	GLUT3	GLUT4	25551(Tax:10116)	25139(Tax:10116)	Gene	Gene	GLUT1|dep|START_ENTITY GLUT1|dep|END_ENTITY	Expression and cellular localization of glucose_transporters -LRB- GLUT1 , GLUT3 , GLUT4 -RRB- during differentiation of myogenic cells isolated from rat foetuses .
9889355	0	GLUT3	23,28	Glucose_transporter_3	0,21	GLUT3	Glucose transporter 3	6515	6515	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Glucose_transporter_3 -LRB- GLUT3 -RRB- protein is present in human myocardium .
17920708	0	GLUT3	15,20	IGF-1	0,5	GLUT3	IGF-1	6515	3479	Gene	Gene	expression|nummod|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1 .
22104347	0	GLUT3	51,56	IGF-1	0,5	GLUT3	IGF-1	25551(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IGF-1 induces hypoxia-inducible factor 1a-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells .
26639784	0	GLUT3	0,5	OCT4	24,28	GLUT3	OCT4	6515	5460	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells .
22521589	0	GLUT3	121,126	brain-derived_neurotrophic_factor	62,95	GLUT3	brain-derived neurotrophic factor	6515	627	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Photoperiod and stress regulation of corticosteroid receptor , brain-derived_neurotrophic_factor , and glucose transporter GLUT3 mRNA in the hippocampus of male Siberian hamsters -LRB- Phodopus sungorus -RRB- .
18435282	0	GLUT4	30,35	AMPK	14,18	GLUT4	AMPK	6517	5563	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Mechanism of AMPK regulating GLUT4 gene expression in skeletal muscle cells -RSB- .
9415393	0	GLUT4	65,70	Akt	22,25	GLUT4	Akt	25139(Tax:10116)	24185(Tax:10116)	Gene	Gene	translocation|nmod|START_ENTITY role|nmod|translocation role|nmod|END_ENTITY	Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells .
10523666	0	GLUT4	59,64	Akt2	32,36	GLUT4	Akt2	25139(Tax:10116)	25233(Tax:10116)	Gene	Gene	translocation|compound|START_ENTITY END_ENTITY|nmod|translocation	A role for protein_kinase_Bbeta / Akt2 in insulin-stimulated GLUT4 translocation in adipocytes .
9421462	0	GLUT4	60,65	C/EBPalpha	84,94	GLUT4	C/EBPalpha	6517	1050	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes .
24500986	0	GLUT4	15,20	CYP2E1	0,6	GLUT4	CYP2E1	25139(Tax:10116)	25086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	CYP2E1 impairs GLUT4 gene expression and function : NRF2 as a possible mediator .
18769028	0	GLUT4	82,87	FXR	54,57	GLUT4	FXR	20528(Tax:10090)	20186(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY element|nmod|promoter element|compound|END_ENTITY	Farnesoid_X_receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter .
18769028	0	GLUT4	29,34	Farnesoid_X_receptor	0,20	GLUT4	Farnesoid X receptor	20528(Tax:10090)	20186(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Farnesoid_X_receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter .
18769028	0	GLUT4	82,87	Farnesoid_X_receptor	0,20	GLUT4	Farnesoid X receptor	20528(Tax:10090)	20186(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY element|nmod|promoter induces|nmod|element induces|nsubj|END_ENTITY	Farnesoid_X_receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter .
11436180	0	GLUT4	74,79	GLUT3	18,23	GLUT4	GLUT3	6517	6515	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Altered GLUT1 and GLUT3 gene expression and subcellular redistribution of GLUT4 : protein in muscle from patients with acanthosis nigricans and severe insulin resistance .
18084728	0	GLUT4	94,99	GLUT3	87,92	GLUT4	GLUT3	25139(Tax:10116)	25551(Tax:10116)	Gene	Gene	GCK|appos|START_ENTITY GCK|appos|END_ENTITY	Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2 , GLUT3 , GLUT4 , GCK , and sulfonylurea_receptor-1 gene expression in the ovariectomized female rat LHA and VMH : impact of estradiol .
8006068	0	GLUT4	76,81	GLUT3	69,74	GLUT4	GLUT3	25139(Tax:10116)	25551(Tax:10116)	Gene	Gene	GLUT1|dep|START_ENTITY GLUT1|dep|END_ENTITY	Expression and cellular localization of glucose_transporters -LRB- GLUT1 , GLUT3 , GLUT4 -RRB- during differentiation of myogenic cells isolated from rat foetuses .
10067007	0	GLUT4	23,28	Glucose_transporter_4	0,21	GLUT4	Glucose transporter 4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Glucose_transporter_4 -LRB- GLUT4 -RRB- mRNA abundance in the adipose tissue and skeletal-muscle tissue of ovariectomized rats treated with 17_beta-estradiol or progesterone .
10080958	0	GLUT4	59,64	IRS-1	14,19	GLUT4	IRS-1	25139(Tax:10116)	25467(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Inhibition of IRS-1 phosphorylation and the alterations of GLUT4 in isolated adipocytes from cachectic tumor-bearing rats .
12641495	0	GLUT4	33,38	Insulin	0,7	GLUT4	Insulin	6517	3630	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Insulin and dexamethasone induce GLUT4 gene expression in foetal brown adipocytes : synergistic effect through CCAAT/enhancer-binding _ protein_alpha .
12097321	0	GLUT4	83,88	KLF15	25,30	GLUT4	KLF15	20528(Tax:10090)	66277(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The Kr ppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4 .
19720047	0	GLUT4	41,46	KLF15	60,65	GLUT4	KLF15	25139(Tax:10116)	85497(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes .
24500986	0	GLUT4	15,20	NRF2	51,55	GLUT4	NRF2	25139(Tax:10116)	83619(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	CYP2E1 impairs GLUT4 gene expression and function : NRF2 as a possible mediator .
15541363	0	GLUT4	75,80	Nuclear_factor_1	0,16	GLUT4	Nuclear factor 1	20528(Tax:10090)	18015(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Nuclear_factor_1 regulates adipose tissue-specific expression in the mouse GLUT4 gene .
9421462	0	GLUT4	60,65	PPARgamma	0,9	GLUT4	PPARgamma	6517	5468	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes .
12777391	0	GLUT4	59,64	Peroxisome_proliferator-activated_receptor-gamma	0,48	GLUT4	Peroxisome proliferator-activated receptor-gamma	25139(Tax:10116)	25664(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma represses GLUT4 promoter activity in primary adipocytes , and rosiglitazone alleviates this effect .
18076383	0	GLUT4	28,33	Rab10	0,5	GLUT4	Rab10	6517	10890	Gene	Gene	translocation|compound|START_ENTITY END_ENTITY|nmod|translocation	Rab10 in insulin-stimulated GLUT4 translocation .
19570034	0	GLUT4	60,65	Rab10	32,37	GLUT4	Rab10	6517	10890	Gene	Gene	translocation|compound|START_ENTITY END_ENTITY|nmod|translocation	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation .
11336646	0	GLUT4	56,61	Rab4	38,42	GLUT4	Rab4	6517	5867	Gene	Gene	translocation|compound|START_ENTITY inhibits|dobj|translocation inhibits|nsubj|Expression Expression|nmod|END_ENTITY	Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein_kinase_B .
12832475	0	GLUT4	16,21	Rab4	106,110	GLUT4	Rab4	20528(Tax:10090)	19341(Tax:10090)	Gene	Gene	translocation|compound|START_ENTITY involves|nsubj|translocation involves|dobj|coupling coupling|nmod|END_ENTITY	Insulin-induced GLUT4 translocation involves protein_kinase_C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin .
7575609	0	GLUT4	60,65	Rab4	0,4	GLUT4	Rab4	25139(Tax:10116)	25532(Tax:10116)	Gene	Gene	colocalized|nmod|START_ENTITY colocalized|nsubjpass|END_ENTITY	Rab4 , but not the transferrin_receptor , is colocalized with GLUT4 in an insulin-sensitive intracellular compartment in rat skeletal muscle .
9348225	0	GLUT4	85,90	Rab4	49,53	GLUT4	Rab4	20528(Tax:10090)	19341(Tax:10090)	Gene	Gene	translocation|compound|START_ENTITY involved|nmod|translocation involved|nsubjpass|END_ENTITY	The small guanosine_triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells .
17019595	0	GLUT4	68,73	SLC2A4	75,81	GLUT4	SLC2A4	6517	6517	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Exercise training increases insulin-stimulated glucose disposal and GLUT4 -LRB- SLC2A4 -RRB- protein content in patients with type 2 diabetes .
10713150	0	GLUT4	51,56	SNAP23	8,14	GLUT4	SNAP23	6517	8773	Gene	Gene	translocation|nmod|START_ENTITY Role|nmod|translocation Role|nmod|END_ENTITY	Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes .
16787385	0	GLUT4	14,19	SREBP-1c	39,47	GLUT4	SREBP-1c	25139(Tax:10116)	78968(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of GLUT4 gene expression by SREBP-1c in adipocytes .
15469990	0	GLUT4	34,39	TI-VAMP	181,188	GLUT4	TI-VAMP	6517	6845	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive_factor-dependent SNARE mechanisms but different v-SNAREs : role of TI-VAMP .
20165829	0	GLUT4	57,62	activating_transcription_factor_6	78,111	GLUT4	activating transcription factor 6	25139(Tax:10116)	304962(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Glucosamine-induced endoplasmic_reticulum_stress affects GLUT4 expression via activating_transcription_factor_6 in rat and human skeletal muscle cells .
17575039	0	GLUT4	49,54	glucose_transporter	28,47	GLUT4	glucose transporter	6517	6517	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Physiological regulation of glucose_transporter -LRB- GLUT4 -RRB- protein content in brown trout -LRB- Salmo trutta -RRB- skeletal muscle .
19549745	0	GLUT4	84,89	glucose_transporter	36,55	GLUT4	glucose transporter	6517	6513	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Insulin-stimulated translocation of glucose_transporter -LRB- GLUT -RRB- 12 parallels that of GLUT4 in normal muscle .
7738859	0	GLUT4	49,54	glucose_transporter	29,48	GLUT4	glucose transporter	6517	6517	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Eccentric exercise decreases glucose_transporter GLUT4 protein in human skeletal muscle .
8224371	0	GLUT4	125,130	glucose_transporter	104,123	GLUT4	glucose transporter	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose_transporter -LRB- GLUT4 -RRB- protein .
8276864	0	GLUT4	80,85	glucose_transporter	54,73	GLUT4	glucose transporter	6517	6517	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Arachidonic_acid down-regulates the insulin-dependent glucose_transporter gene -LRB- GLUT4 -RRB- in 3T3-L1 adipocytes by inhibiting transcription and enhancing mRNA turnover .
9301415	0	GLUT4	48,53	glucose_transporter	27,46	GLUT4	glucose transporter	282359(Tax:9913)	282359(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Weaning marginally affects glucose_transporter -LRB- GLUT4 -RRB- expression in calf muscles and adipose tissues .
24906930	0	GLUT4	40,45	glucose_transporter-4	17,38	GLUT4	glucose transporter-4	282359(Tax:9913)	282359(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Myostatin alters glucose_transporter-4 -LRB- GLUT4 -RRB- expression in bovine skeletal muscles and myoblasts isolated from double-muscled -LRB- DM -RRB- and normal-muscled -LRB- NM -RRB- Japanese shorthorn cattle .
22079207	0	GLUT4	96,101	glucose_transporter_4	73,94	GLUT4	glucose transporter 4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Protein restriction during gestation alters histone modifications at the glucose_transporter_4 -LRB- GLUT4 -RRB- promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring .
23074218	0	GLUT4	46,51	glucose_transporter_4	23,44	GLUT4	glucose transporter 4	6517	6517	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Vitamin_D up-regulates glucose_transporter_4 -LRB- GLUT4 -RRB- translocation and glucose utilization mediated by cystathionine-y-lyase -LRB- CSE -RRB- activation and H2S formation in 3T3L1 adipocytes .
23135276	0	GLUT4	43,48	glucose_transporter_4	20,41	GLUT4	glucose transporter 4	20528(Tax:10090)	20528(Tax:10090)	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Metformin regulates glucose_transporter_4 -LRB- GLUT4 -RRB- translocation through AMP-activated protein kinase -LRB- AMPK -RRB- - mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells .
9312184	0	GLUT4	115,120	glucose_transporter_type_4	87,113	GLUT4	glucose transporter type 4	20528(Tax:10090)	20528(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose_transporter_type_4 -LRB- GLUT4 -RRB- gene .
9392481	0	GLUT4	21,26	insulin	10,17	GLUT4	insulin	6517	3630	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique .
8710883	0	GLUT4	137,142	insulin-responsive_glucose_transporter	97,135	GLUT4	insulin-responsive glucose transporter	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Evidence for an insulin_receptor_substrate_1 independent insulin signaling pathway that mediates insulin-responsive_glucose_transporter -LRB- GLUT4 -RRB- translocation .
23493574	0	GLUT4	18,23	miRNA-93	0,8	GLUT4	miRNA-93	6517	407051	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	miRNA-93 inhibits GLUT4 and is overexpressed in adipose_tissue of polycystic_ovary_syndrome patients and women with insulin resistance .
19720795	0	GLUT4	87,92	neuroendocrine-specific_protein-like_1	19,57	GLUT4	neuroendocrine-specific protein-like 1	20528(Tax:10090)	20167(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of neuroendocrine-specific_protein-like_1 in membrane translocation of GLUT4 .
23907013	0	GLUT4	23,28	orexin_A	11,19	GLUT4	orexin A	25139(Tax:10116)	25723(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of orexin_A on GLUT4 expression and lipid content via MAPK signaling in 3T3-L1 adipocytes .
12637564	0	GLUT4	32,37	p38	50,53	GLUT4	p38	6517	1432	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis .
12777397	0	GLUT4	101,106	peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	18,85	GLUT4	peroxisome proliferator-activated receptor gamma coactivator-1alpha	6517	10891	Gene	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|down-regulates down-regulates|amod|END_ENTITY	Overexpression of peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles .
16105857	0	GLUT4_enhancer_factor	21,42	AMP-activated_protein_kinase	76,104	GLUT4 enhancer factor	AMP-activated protein kinase	56731	5563	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of muscle GLUT4_enhancer_factor and myocyte_enhancer_factor_2 by AMP-activated_protein_kinase .
18216015	0	GLUT4_enhancer_factor	0,21	MEF2A	43,48	GLUT4 enhancer factor	MEF2A	56731	4205	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GLUT4_enhancer_factor -LRB- GEF -RRB- interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes .
12031501	0	GLUT5	75,80	fructose_transporter	53,73	GLUT5	fructose transporter	56485(Tax:10090)	56485(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Cloning and functional characterization of the mouse fructose_transporter , GLUT5 .
24519932	0	GLUT8	23,28	Glucose_transporter_8	0,21	GLUT8	Glucose transporter 8	56017(Tax:10090)	56017(Tax:10090)	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Glucose_transporter_8 -LRB- GLUT8 -RRB- mediates fructose-induced de novo lipogenesis and macrosteatosis .
15013641	0	GLUT8	43,48	glucose_transporter_8	20,41	GLUT8	glucose transporter 8	282867(Tax:9913)	282867(Tax:9913)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of glucose_transporter_8 -LRB- GLUT8 -RRB- in the ovine placenta of normal and growth restricted fetuses .
7820675	0	GLUT_1	66,72	glucose_transporter	45,64	GLUT 1	glucose transporter	6513	6513	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Immunocytochemical distribution of the brain glucose_transporter -LRB- GLUT_1 -RRB- in experimental gliosis .
8863182	0	GLUT_1	108,114	insulin_receptor	24,40	GLUT 1	insulin receptor	24778(Tax:10116)	24954(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Dexamethasone modulates insulin_receptor expression and subcellular distribution of the glucose transporter GLUT_1 in UMR 106-01 , a clonal osteogenic_sarcoma cell line .
7744215	0	GLUT_2	108,114	glucose_transporter_2	85,106	GLUT 2	glucose transporter 2	6514	6514	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional analysis of DNA-elements involved in transcriptional control of the human glucose_transporter_2 -LRB- GLUT_2 -RRB- gene in the insulin-producing cell line beta_TC-3 .
8005559	0	GLUT_4	21,27	Glucose_transporter	0,19	GLUT 4	Glucose transporter	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Glucose_transporter -LRB- GLUT_4 -RRB- content and insulin receptor kinase activity in muscles of the LA/N-cp rat .
1521731	0	GLUT_4	61,67	Insulin	0,7	GLUT 4	Insulin	6517	3630	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Insulin receptor and insulin-responsive glucose transporter -LRB- GLUT_4 -RRB- mutations and polymorphisms in a Welsh type 2 -LRB- non-insulin-dependent -RRB- diabetic population .
11906177	0	GLUT_4	66,72	glucose_transporter	45,64	GLUT 4	glucose transporter	20528(Tax:10090)	20528(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Exercise-induced transcription of the muscle glucose_transporter -LRB- GLUT_4 -RRB- gene .
1324860	0	GLUT_4	74,80	glucose_transporter	53,72	GLUT 4	glucose transporter	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Normal insulin_receptor tyrosine kinase activity and glucose_transporter -LRB- GLUT_4 -RRB- levels in the skeletal muscle of hyperinsulinaemic hypertensive rats .
20925583	0	GLYAT	52,57	glycine_N-acyltransferase	25,50	GLYAT	glycine N-acyltransferase	10249	10249	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of glycine_N-acyltransferase -LRB- GLYAT -RRB- in a French Caucasian population .
16271045	0	GLYT1	70,75	PSD-95	24,30	GLYT1	PSD-95	116509(Tax:10116)	29495(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The scaffolding protein PSD-95 interacts with the glycine transporter GLYT1 and impairs its internalization .
16181645	0	GLYT1	24,29	Sec3	45,49	GLYT1	Sec3	6536	55763	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The glycine transporter GLYT1 interacts with Sec3 , a component of the exocyst complex .
16884688	0	GLYT2	27,32	SLC6A5	34,40	GLYT2	SLC6A5	9152	9152	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations within the human GLYT2 -LRB- SLC6A5 -RRB- gene associated with hyperekplexia .
8358016	0	GM-CSF	15,21	5-lipoxygenase	41,55	GM-CSF	5-lipoxygenase	1437	240	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Enhancement by GM-CSF of agonist-induced 5-lipoxygenase activation in human neutrophils involves protein synthesis and gene transcription .
17549399	0	GM-CSF	0,6	CCL2	38,42	GM-CSF	CCL2	12981(Tax:10090)	20296(Tax:10090)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	GM-CSF up-regulates the expression of CCL2 by T lymphocytes in mammary_tumor-bearing mice .
10861034	0	GM-CSF	29,35	CD11c	55,60	GM-CSF	CD11c	12981(Tax:10090)	16411(Tax:10090)	Gene	Gene	expands|nsubj|START_ENTITY expands|dobj|END_ENTITY	Polyethylene_glycol-modified GM-CSF expands CD11b -LRB- high -RRB- CD11c -LRB- high -RRB- but notCD11b -LRB- low -RRB- CD11c -LRB- high -RRB- murine dendritic cells in vivo : a comparative analysis with Flt3_ligand .
19171501	0	GM-CSF	86,92	CD25	134,138	GM-CSF	CD25	12981(Tax:10090)	16184(Tax:10090)	Gene	Gene	delays|appos|START_ENTITY using|dobj|delays cells|acl|using Modulation|nmod|cells type|nsubj|Modulation type|nmod|function function|compound|END_ENTITY	Modulation of dendritic cells using granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- delays type 1 diabetes by enhancing CD4 + CD25 + regulatory T cell function .
10760792	0	GM-CSF	32,38	CD4	158,161	GM-CSF	CD4	12981(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY Culture|nmod|cells generates|nsubj|Culture generates|dobj|cells cells|acl:relcl|induce induce|dobj|anergy anergy|compound|END_ENTITY	Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro .
1354325	0	GM-CSF	0,6	CD4	21,24	GM-CSF	CD4	1437	920	Gene	Gene	production|amod|START_ENTITY production|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	GM-CSF production by CD4 + T-lymphocytes is selectively impaired during the course of HIV-1_infection .
18603443	0	GM-CSF	108,114	CD4	36,39	GM-CSF	CD4	1437	920	Gene	Gene	coexpress|xcomp|START_ENTITY coexpress|nsubj|+ +|compound|END_ENTITY	Mycobacterium_tuberculosis-specific CD4 + , IFNgamma + , and TNFalpha + multifunctional memory T cells coexpress GM-CSF .
19171501	0	GM-CSF	86,92	CD4	130,133	GM-CSF	CD4	12981(Tax:10090)	12504(Tax:10090)	Gene	Gene	delays|appos|START_ENTITY using|dobj|delays cells|acl|using Modulation|nmod|cells type|nsubj|Modulation type|nmod|function function|compound|END_ENTITY	Modulation of dendritic cells using granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- delays type 1 diabetes by enhancing CD4 + CD25 + regulatory T cell function .
21931646	0	GM-CSF	0,6	CD4	92,95	GM-CSF	CD4	1437	920	Gene	Gene	production|amod|START_ENTITY allows|nsubj|production allows|dobj|identification identification|nmod|antigens antigens|acl|recognized recognized|nmod|cells cells|compound|END_ENTITY	GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4 + T cells following smallpox vaccination .
22345669	0	GM-CSF	55,61	CD4	65,68	GM-CSF	CD4	1437	920	Gene	Gene	production|nmod|START_ENTITY regulates|dobj|production regulates|nmod|cells cells|amod|END_ENTITY	Inflammasome-derived IL-1b regulates the production of GM-CSF by CD4 -LRB- + -RRB- T cells and y T cells .
25773153	0	GM-CSF	0,6	CD4	21,24	GM-CSF	CD4	1437	920	Gene	Gene	production|amod|START_ENTITY production|nmod|T T|compound|END_ENTITY	GM-CSF production by CD4 -LRB- + -RRB- T cells in MS patients : Regulation by regulatory T cells and vitamin D. BACKGROUND/OBJECTIVE : Data from animal models of MS suggest that GM-CSF -LRB- + -RRB- CD4 -LRB- + -RRB- T cells are pathogenic cells .
26448779	0	GM-CSF	91,97	CD4	109,112	GM-CSF	CD4	116630(Tax:10116)	24932(Tax:10116)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Aging diminishes the resistance of AO rats to EAE : putative role of enhanced generation of GM-CSF Expressing CD4 + T cells in aged rats .
23088985	0	GM-CSF	44,50	CG0070	34,40	GM-CSF	CG0070	1437	3344628(Tax:196627)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A first in human phase 1 study of CG0070 , a GM-CSF expressing oncolytic adenovirus , for the treatment of nonmuscle invasive bladder_cancer .
23886206	0	GM-CSF	129,135	COX-2	96,101	GM-CSF	COX-2	12981(Tax:10090)	17709(Tax:10090)	Gene	Gene	IL-2|acl|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
9850165	0	GM-CSF	82,88	CSF-1	0,5	GM-CSF	CSF-1	12981(Tax:10090)	12977(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|compound|END_ENTITY	CSF-1 regulation of Il6 gene expression by murine macrophages : a pivotal role for GM-CSF .
10641570	0	GM-CSF	15,21	Cdc25A	87,93	GM-CSF	Cdc25A	1437	993	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	The effects of GM-CSF , steel_factor and MIP-1alpha on the expression and activation of Cdc25A phosphatase in Mo7e cells .
20398804	0	GM-CSF	18,24	ERK	0,3	GM-CSF	ERK	1437	5594	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	ERK activation by GM-CSF reduces effectiveness of p38 inhibitor on inhibiting TNFalpha release .
12475968	0	GM-CSF	22,28	Ets1	82,86	GM-CSF	Ets1	1437	2113	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Calcium regulation of GM-CSF by calmodulin-dependent kinase II phosphorylation of Ets1 .
25340460	0	GM-CSF	25,31	Fc_Gamma_Receptor_IIb	0,21	GM-CSF	Fc Gamma Receptor IIb	1437	2213	Gene	Gene	Inhibition|compound|START_ENTITY END_ENTITY|nmod|Inhibition	Fc_Gamma_Receptor_IIb on GM-CSF Macrophages Controls Immune Complex Mediated Inhibition of Inflammatory Signals .
20731086	0	GM-CSF	101,107	Flt3-L	89,95	GM-CSF	Flt3-L	12981(Tax:10090)	14256(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Identification of mouse dentritic cells expanded in vivo by combined over-expression of Flt3-L with GM-CSF -RSB- .
10452050	0	GM-CSF	41,47	G-CSF	17,22	GM-CSF	G-CSF	116630(Tax:10116)	25610(Tax:10116)	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	-LSB- Levels of serum G-CSF and supplement of GM-CSF in rats sustaining delayed resuscitation after major burn -RSB- .
10537336	0	GM-CSF	86,92	G-CSF	125,130	GM-CSF	G-CSF	1437	1440	Gene	Gene	granulocyte-CSF|appos|START_ENTITY Selective|nmod|granulocyte-CSF Selective|acl|END_ENTITY	Selective in vivo mobilization with granulocyte_macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / granulocyte-CSF as compared to G-CSF alone of dendritic cell progenitors from peripheral blood progenitor cells in patients with advanced breast_cancer undergoing autologous transplantation .
10982281	0	GM-CSF	26,32	G-CSF	18,23	GM-CSF	G-CSF	1437	1440	Gene	Gene	vs|compound|START_ENTITY vs|dep|Use Use|nmod|END_ENTITY	Use of concurrent G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells in children with malignant_disease .
10982281	0	GM-CSF	26,32	G-CSF	36,41	GM-CSF	G-CSF	1437	1440	Gene	Gene	vs|compound|START_ENTITY END_ENTITY|nsubj|vs	Use of concurrent G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells in children with malignant_disease .
12621492	0	GM-CSF	189,195	G-CSF	125,130	GM-CSF	G-CSF	1437	1440	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY granulocyte-colony-stimulating_factor|nmod|granulocyte-macrophage_colony-stimulating_factor granulocyte-colony-stimulating_factor|appos|END_ENTITY	Engraftment syndrome after autologous hematopoietic stem cell transplant supported by granulocyte-colony-stimulating_factor -LRB- G-CSF -RRB- versus granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
1373689	0	GM-CSF	108,114	G-CSF	222,227	GM-CSF	G-CSF	1437	1440	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Retinoic_acid acts to neutralize the inhibitory effect of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on alkaline phosphatase activity of neutrophils that is induced by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
1379838	0	GM-CSF	31,37	G-CSF	120,125	GM-CSF	G-CSF	1437	1440	Gene	Gene	cell|nmod|START_ENTITY precursor|nsubj|cell precursor|amod|capable capable|xcomp|produce produce|nmod|property property|acl|secrete secrete|dobj|END_ENTITY	Hypothesis : the target cell of GM-CSF is a macrophage precursor capable to produce cells with the property to secrete a G-CSF like activity .
16646673	0	GM-CSF	194,200	G-CSF	213,218	GM-CSF	G-CSF	1437	1440	Gene	Gene	START_ENTITY|acl|followed followed|nmod|END_ENTITY	No polarization of type 1 or type 2 precursor dendritic cells in peripheral blood stem cell collections of non-hodgkin 's _ lymphoma patients mobilized with cyclophosphamide plus G-CSF , GM-CSF , or GM-CSF followed by G-CSF .
1696146	0	GM-CSF	130,136	G-CSF	139,144	GM-CSF	G-CSF	1437	1440	Gene	Gene	cyclic_hematopoiesis|appos|START_ENTITY cyclic_hematopoiesis|amod|interleukin-3 interleukin-3|advmod|END_ENTITY	A comparison of treatment of canine cyclic_hematopoiesis with recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , G-CSF interleukin-3 , and canine G-CSF .
1700027	0	GM-CSF	76,82	G-CSF	6,11	GM-CSF	G-CSF	1437	1440	Gene	Gene	presence|nmod|START_ENTITY produced|nmod|presence produced|nsubj|END_ENTITY	Human G-CSF produced by adherent cells in the presence of human recombinant GM-CSF .
1703481	0	GM-CSF	38,44	G-CSF	89,94	GM-CSF	G-CSF	116630(Tax:10116)	25610(Tax:10116)	Gene	Gene	granulocyte-macrophage|appos|START_ENTITY granulocyte-macrophage|appos|END_ENTITY	Production of granulocyte-macrophage -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- by rat clonal osteoblastic cell population CRP 10/30 and the immortalized cell line IRC10/30-myc 1 stimulated by tumor_necrosis_factor_alpha .
1709645	0	GM-CSF	131,137	G-CSF	182,187	GM-CSF	G-CSF	1437	1440	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Modulation by tumor_necrosis_factor-alpha of human astroglial cell production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
18537618	0	GM-CSF	74,80	G-CSF	67,72	GM-CSF	G-CSF	1437	1440	Gene	Gene	factors|advmod|START_ENTITY factors|appos|END_ENTITY	Old friends in new constellations -- the hematopoetic growth factors G-CSF , GM-CSF , and EPO for the treatment of neurological_diseases .
20043577	0	GM-CSF	147,153	G-CSF	84,89	GM-CSF	G-CSF	1437	1440	Gene	Gene	colony_stimulating_factor|appos|START_ENTITY levels|dep|colony_stimulating_factor levels|appos|END_ENTITY	-LSB- The plasma levels and diagnostic utility of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage _ - _ colony_stimulating_factor -LRB- GM-CSF -RRB- in patients with I and II stage of breast_cancer -RSB- .
2483336	0	GM-CSF	68,74	G-CSF	76,81	GM-CSF	G-CSF	12981(Tax:10090)	12985(Tax:10090)	Gene	Gene	Multi-CSF|dep|START_ENTITY Multi-CSF|dep|END_ENTITY	Cellular processing of murine colony-stimulating factor -LRB- Multi-CSF , GM-CSF , G-CSF -RRB- receptors by normal hemopoietic cells and cell lines .
7506580	0	GM-CSF	194,200	G-CSF	187,192	GM-CSF	G-CSF	1437	1440	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
7681699	0	GM-CSF	73,79	G-CSF	124,129	GM-CSF	G-CSF	1437	1440	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Comparative effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy .
7690442	0	GM-CSF	86,92	G-CSF	195,200	GM-CSF	G-CSF	1437	1440	Gene	Gene	provides|nsubj|START_ENTITY provides|advcl|END_ENTITY	Cytogenetic studies of non-lymphocytic_neoplasias using hematopoietic growth factors : GM-CSF provides pronounced mitotic increase and improvement of the quality of banded chromosomes compared to G-CSF .
8552986	0	GM-CSF	165,171	G-CSF	158,163	GM-CSF	G-CSF	1437	1440	Gene	Gene	START_ENTITY|nsubj|Adhesion Adhesion|nmod|erythrocytes erythrocytes|dep|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8554685	0	GM-CSF	48,54	G-CSF	41,46	GM-CSF	G-CSF	1437	1440	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
8673471	0	GM-CSF	114,120	G-CSF	53,58	GM-CSF	G-CSF	1437	1440	Gene	Gene	granulocyte_colony_stimulating_factor|appos|START_ENTITY granulocyte_colony_stimulating_factor|appos|END_ENTITY	Expression of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte/macrophage _ colony_stimulating_factor -LRB- GM-CSF -RRB- mRNA upon stimulation with phorbol_ester .
8757506	0	GM-CSF	209,215	G-CSF	39,44	GM-CSF	G-CSF	1437	1440	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY comparison|nmod|granulocyte-macrophage_colony-stimulating_factor increases|parataxis|comparison increases|nsubj|Granulocyte_colony-stimulating_factor Granulocyte_colony-stimulating_factor|appos|END_ENTITY	Granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- increases neutrophil migration across vascular endothelium independent of an effect on adhesion : comparison with granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
9422470	0	GM-CSF	33,39	G-CSF	25,30	GM-CSF	G-CSF	1437	1440	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|compound|END_ENTITY	Randomized comparison of G-CSF + GM-CSF vs G-CSF alone for mobilization of peripheral blood stem cells : effects on hematopoietic recovery after high-dose chemotherapy .
9829843	0	GM-CSF	86,92	G-CSF	102,107	GM-CSF	G-CSF	1437	1440	Gene	Gene	factor|dep|START_ENTITY factor|dobj|administration administration|amod|END_ENTITY	The effect of recombinant human granulocyte/macrophage-colony-stimulating _ factor -LRB- rHu GM-CSF -RRB- and rHu G-CSF administration on neutrophil chemiluminescence assay in patients following cyclic chemotherapy .
1830593	0	GM-CSF	0,6	GM-CSF	35,41	GM-CSF	GM-CSF	1437	1437	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	GM-CSF and phorbol_esters modulate GM-CSF receptor expression by independent mechanisms .
1830593	0	GM-CSF	35,41	GM-CSF	0,6	GM-CSF	GM-CSF	1437	1437	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression modulate|nsubj|END_ENTITY	GM-CSF and phorbol_esters modulate GM-CSF receptor expression by independent mechanisms .
11107242	0	GM-CSF	61,67	Granulocyte-Macrophage_Colony-Stimulating_Factor	11,59	GM-CSF	Granulocyte-Macrophage Colony-Stimulating Factor	1437	1437	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	A Role for Granulocyte-Macrophage_Colony-Stimulating_Factor -LRB- GM-CSF -RRB- in the Treatment of Neutropenic Patients with Pneumonia .
12421947	0	GM-CSF	209,215	Granulocyte-macrophage_colony-stimulating_factor	0,48	GM-CSF	Granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	1437	Gene	Gene	receptor|compound|START_ENTITY ectodomain|nmod|receptor evidence|nmod|ectodomain END_ENTITY|dep|evidence	Granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and inflammatory stimuli up-regulate secretion of the soluble GM-CSF receptor in human monocytes : evidence for ectodomain shedding of the cell surface GM-CSF receptor alpha subunit .
11461069	0	GM-CSF	77,83	HER2	87,91	GM-CSF	HER2	1437	2064	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	A phase II study of the bispecific antibody MDX-H210 -LRB- anti-HER2 x CD64 -RRB- with GM-CSF in HER2 + advanced prostate_cancer .
20877352	0	GM-CSF	12,18	HER2	78,82	GM-CSF	HER2	1437	2064	Gene	Gene	trastuzumab|compound|START_ENTITY Addition|nmod|trastuzumab stabilises|nsubj|Addition stabilises|dobj|disease disease|nmod|patients patients|compound|END_ENTITY	Addition of GM-CSF to trastuzumab stabilises disease in trastuzumab-resistant HER2 + metastatic breast_cancer patients .
25646302	0	GM-CSF	34,40	IFN_regulatory_factor_8	0,23	GM-CSF	IFN regulatory factor 8	12981(Tax:10090)	15900(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	IFN_regulatory_factor_8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation .
1834679	0	GM-CSF	0,6	IL-1	27,31	GM-CSF	IL-1	1437	3552	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	GM-CSF in association with IL-1 triggers day-8 CFU-S into cell cycle : role of histamine .
7506580	0	GM-CSF	194,200	IL-1	202,206	GM-CSF	IL-1	1437	3552	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
14567558	0	GM-CSF	24,30	IL-10	9,14	GM-CSF	IL-10	1437	3586	Gene	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Elevated IL-10 inhibits GM-CSF synthesis in pulmonary_alveolar_proteinosis .
26826242	0	GM-CSF	106,112	IL-10	128,133	GM-CSF	IL-10	1437	3586	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Autoreactive T Cells from Patients with Myasthenia_Gravis Are Characterized by Elevated IL-17 , IFN-y , and GM-CSF and Diminished IL-10 Production .
8552986	0	GM-CSF	165,171	IL-10	130,135	GM-CSF	IL-10	1437	3586	Gene	Gene	START_ENTITY|nsubj|Adhesion Adhesion|nmod|erythrocytes erythrocytes|dep|G-CSF G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
9546312	0	GM-CSF	84,90	IL-10	0,5	GM-CSF	IL-10	1437	3586	Gene	Gene	secretion|amod|START_ENTITY effects|nmod|secretion secretion|dep|effects secretion|amod|END_ENTITY	IL-10 as an autocrine regulator of CSF secretion by monocytes : disparate effects on GM-CSF and G-CSF secretion .
17555818	0	GM-CSF	47,53	IL-17	0,5	GM-CSF	IL-17	1437	3605	Gene	Gene	effects|nmod|START_ENTITY attenuates|dobj|effects attenuates|nsubj|END_ENTITY	IL-17 attenuates the anti-apoptotic effects of GM-CSF in human neutrophils .
8552986	0	GM-CSF	165,171	IL-1RA	110,116	GM-CSF	IL-1RA	1437	3557	Gene	Gene	START_ENTITY|nsubj|Adhesion Adhesion|nmod|erythrocytes erythrocytes|dep|G-CSF G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
10857757	0	GM-CSF	120,126	IL-1_beta	91,100	GM-CSF	IL-1 beta	1437	3553	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The role of protein_kinase_C and calcium in induction of human polymorphonuclear leukocyte IL-1_beta gene expression by GM-CSF .
1536949	0	GM-CSF	161,167	IL-1_beta	20,29	GM-CSF	IL-1 beta	1437	3553	Gene	Gene	granulocyte-macrophage_colony-stimulating_factor|appos|START_ENTITY regulated|nmod|granulocyte-macrophage_colony-stimulating_factor regulated|nsubjpass|expression expression|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , M-CSF , and IL-3 .
23886206	0	GM-CSF	129,135	IL-1b	103,108	GM-CSF	IL-1b	12981(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-2|acl|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
1634251	0	GM-CSF	169,175	IL-2	109,113	GM-CSF	IL-2	1437	3558	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	Natural killer -LRB- NK -RRB- cell activity in human long-term bone marrow cultures -LRB- LTBMC -RRB- : effects of interleukin-2 -LRB- IL-2 -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on the progenitor cells .
16783532	0	GM-CSF	80,86	IL-2	107,111	GM-CSF	IL-2	1437	3558	Gene	Gene	granulocyte-macrophage_colony_stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony_stimulating_factor|appos|END_ENTITY	In vivo effects of sequential granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- and interleukin-2 -LRB- IL-2 -RRB- on circulating dendritic cells -LRB- DC -RRB- in patients with surgically resected high risk cutaneous melanoma .
7506580	0	GM-CSF	194,200	IL-2	208,212	GM-CSF	IL-2	1437	3558	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
26220255	0	GM-CSF	34,40	IL-23	71,76	GM-CSF	IL-23	12981(Tax:10090)	83430(Tax:10090)	Gene	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23 .
10477722	0	GM-CSF	126,132	IL-3	150,154	GM-CSF	IL-3	1437	3562	Gene	Gene	sequence|appos|START_ENTITY sequence|amod|interleukin-3 interleukin-3|dep|END_ENTITY	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors that is serine-phosphorylated by GM-CSF .
10477722	0	GM-CSF	209,215	IL-3	150,154	GM-CSF	IL-3	1437	3562	Gene	Gene	serine-phosphorylated|nmod|START_ENTITY serine-phosphorylated|nsubj|Identification Identification|nmod|sequence sequence|amod|interleukin-3 interleukin-3|dep|END_ENTITY	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors that is serine-phosphorylated by GM-CSF .
10490850	0	GM-CSF	77,83	IL-3	72,76	GM-CSF	IL-3	1437	3562	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
11399637	0	GM-CSF	65,71	IL-3	92,96	GM-CSF	IL-3	1437	3562	Gene	Gene	Granulocyte-Macrophage_Colony_Stimulating_Factor|appos|START_ENTITY Granulocyte-Macrophage_Colony_Stimulating_Factor|appos|END_ENTITY	Implication of Granulocyte-Macrophage_Colony_Stimulating_Factor -LRB- GM-CSF -RRB- and Interleukin-3 -LRB- IL-3 -RRB- in Children with Acute_Myeloid_Leukaemia -LRB- AML -RRB- ; Malignancy .
1358241	0	GM-CSF	134,140	IL-3	160,164	GM-CSF	IL-3	1437	3562	Gene	Gene	granulocyte-macrophage_colony_stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony_stimulating_factor|appos|END_ENTITY	Upregulation of HLA class II , but not intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- by granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- or interleukin-3 -LRB- IL-3 -RRB- in synergy with dexamethasone .
15481143	0	GM-CSF	67,73	IL-3	0,4	GM-CSF	IL-3	1437	3562	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	IL-3 in dendritic cell development and function : a comparison with GM-CSF and IL-4 .
15777160	0	GM-CSF	59,65	IL-3	54,58	GM-CSF	IL-3	1437	3562	Gene	Gene	locus|nsubj|START_ENTITY Mechanisms|parataxis|locus Mechanisms|nmod|END_ENTITY	Mechanisms of transcriptional regulation of the human IL-3 / GM-CSF locus by inducible tissue-specific promoters and enhancers .
17273755	0	GM-CSF	21,27	IL-3	0,4	GM-CSF	IL-3	1437	3562	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells .
1825663	0	GM-CSF	27,33	IL-3	0,4	GM-CSF	IL-3	1437	3562	Gene	Gene	binding|advmod|START_ENTITY inhibits|xcomp|binding inhibits|nsubj|END_ENTITY	IL-3 specifically inhibits GM-CSF binding to the higher affinity receptor .
2049340	0	GM-CSF	138,144	IL-3	106,110	GM-CSF	IL-3	1437	3562	Gene	Gene	gene|amod|START_ENTITY box|nmod|gene coordinate|nmod|box coordinate|dobj|regulation regulation|nmod|gene gene|compound|END_ENTITY	Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene : coordinate regulation of the IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation .
2049340	0	GM-CSF	138,144	IL-3	66,70	GM-CSF	IL-3	1437	3562	Gene	Gene	gene|amod|START_ENTITY box|nmod|gene coordinate|nmod|box Definition|dep|coordinate Definition|nmod|motif motif|nmod|sequence sequence|nmod|gene gene|compound|END_ENTITY	Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene : coordinate regulation of the IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation .
21262803	0	GM-CSF	11,17	IL-3	6,10	GM-CSF	IL-3	12981(Tax:10090)	16187(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY support|nsubj|mice END_ENTITY|parataxis|support	Human IL-3 / GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung .
21831442	0	GM-CSF	60,66	IL-3	55,59	GM-CSF	IL-3	1437	3562	Gene	Gene	START_ENTITY|dep|element element|nmod|END_ENTITY	NF-kB and BRG1 bind a distal regulatory element in the IL-3 / GM-CSF locus .
2201826	0	GM-CSF	29,35	IL-3	0,4	GM-CSF	IL-3	1437	3562	Gene	Gene	the|nmod|START_ENTITY inhibits|dobj|the inhibits|nsubj|END_ENTITY	IL-3 inhibits the binding of GM-CSF to AML_blasts , but the two cytokines act synergistically in supporting blast proliferation .
23024272	0	GM-CSF	59,65	IL-3	54,58	GM-CSF	IL-3	1437	3562	Gene	Gene	locus|amod|START_ENTITY controlled|nsubjpass|locus expression|parataxis|controlled expression|nmod|END_ENTITY	The inducible tissue-specific expression of the human IL-3 / GM-CSF locus is controlled by a complex array of developmentally regulated enhancers .
2444835	0	GM-CSF	29,35	IL-3	23,27	GM-CSF	IL-3	1437	3562	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of recombinant IL-3 , GM-CSF , and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures .
2483920	0	GM-CSF	0,6	IL-3	48,52	GM-CSF	IL-3	12981(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY preferential|nsubj|expression preferential|nmod|expression expression|appos|END_ENTITY	GM-CSF expression is preferential to multi-CSF -LRB- IL-3 -RRB- expression in murine T lymphocyte clones .
7516914	0	GM-CSF	16,22	IL-3	106,110	GM-CSF	IL-3	1437	3562	Gene	Gene	Potentiation|nmod|START_ENTITY induced|nsubj|Potentiation induced|dobj|mobilization mobilization|acl|circulating circulating|nmod|pretreatment pretreatment|nmod|END_ENTITY	Potentiation of GM-CSF or G-CSF induced mobilization of circulating progenitor cells by pretreatment with IL-3 and harvest by apheresis .
7534715	0	GM-CSF	61,67	IL-3	49,53	GM-CSF	IL-3	12981(Tax:10090)	16187(Tax:10090)	Gene	Gene	START_ENTITY|nmod|chronopharmacology chronopharmacology|nmod|END_ENTITY	In vitro chronopharmacology of recombinant mouse IL-3 , mouse GM-CSF , and human G-CSF on murine myeloid progenitor cells .
7545466	0	GM-CSF	104,110	IL-3	128,132	GM-CSF	IL-3	1437	3562	Gene	Gene	role|appos|START_ENTITY role|amod|interleukin-3 interleukin-3|dep|END_ENTITY	Evidence for a signaling role for the alpha chains of granulocyte-macrophage colony-stimulating factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors : divergent signaling pathways between GM-CSF/IL -3 and IL-5 .
7615047	0	GM-CSF	49,55	IL-3	36,40	GM-CSF	IL-3	1437	3562	Gene	Gene	IL-11|dep|START_ENTITY IL-11|dep|END_ENTITY	Influence of cytokines -LRB- IL-1_alpha , IL-3 , IL-11 , GM-CSF -RRB- on megakaryocyte-fibroblast interactions in normal human bone marrow .
7835337	0	GM-CSF	85,91	IL-3	80,84	GM-CSF	IL-3	1437	3562	Gene	Gene	receptors|amod|START_ENTITY Suppression|parataxis|receptors Suppression|nmod|END_ENTITY	Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3 / GM-CSF receptors .
7858491	0	GM-CSF	40,46	IL-3	48,52	GM-CSF	IL-3	1437	3562	Gene	Gene	configuration|nmod|START_ENTITY configuration|appos|END_ENTITY	Expression and genomic configuration of GM-CSF , IL-3 , M-CSF receptor -LRB- C-FMS -RRB- , early_growth_response_gene-1 _ -LRB- EGR-1 -RRB- and M-CSF genes in primary myelodysplastic_syndromes .
8788116	0	GM-CSF	97,103	IL-3	37,41	GM-CSF	IL-3	12981(Tax:10090)	16187(Tax:10090)	Gene	Gene	interleukin-3|appos|START_ENTITY interleukin-3|appos|END_ENTITY	Effect of combination interleukin-3 -LRB- IL-3 -RRB- and granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- on hematopoiesis administered to retrovirus-infected immunodeficient mice receiving dose-escalation zidovudine -LRB- AZT -RRB- .
8972491	0	GM-CSF	78,84	IL-3	101,105	GM-CSF	IL-3	12981(Tax:10090)	16187(Tax:10090)	Gene	Gene	interleukin_3|appos|START_ENTITY interleukin_3|appos|END_ENTITY	The beta_c component of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / interleukin_3 -LRB- IL-3 -RRB- / IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression .
9794243	0	GM-CSF	75,81	IL-3	65,69	GM-CSF	IL-3	1437	3562	Gene	Gene	family|amod|START_ENTITY IL-5|dep|family Regulation|parataxis|IL-5 Regulation|nmod|END_ENTITY	Regulation of proliferation , differentiation and survival by the IL-3 / IL-5 / GM-CSF receptor family .
10940870	0	GM-CSF	53,59	IL-4	78,82	GM-CSF	IL-4	12981(Tax:10090)	16189(Tax:10090)	Gene	Gene	doses|nmod|START_ENTITY generated|nmod|doses generated|nmod|absence absence|nmod|END_ENTITY	Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo .
15213252	0	GM-CSF	38,44	IL-4	0,4	GM-CSF	IL-4	1437	3565	Gene	Gene	involvement|nmod|START_ENTITY alone|nmod|involvement transforms|advmod|alone transforms|nsubj|END_ENTITY	IL-4 alone without the involvement of GM-CSF transforms human peripheral blood monocytes to a CD1a -LRB- dim -RRB- , CD83 -LRB- + -RRB- myeloid dendritic cell subset .
15703830	0	GM-CSF	86,92	IL-4	0,4	GM-CSF	IL-4	1437	3565	Gene	Gene	supported|nmod|START_ENTITY monocytes|acl|supported survival|nmod|monocytes inhibit|dobj|survival inhibit|nsubj|END_ENTITY	IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF .
15907205	0	GM-CSF	139,145	IL-4	116,120	GM-CSF	IL-4	1437	3565	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Research upregulation of CD23 -LRB- FcepsilonRII -RRB- expression in human airway smooth muscle cells -LRB- huASMC -RRB- in response to IL-4 , GM-CSF , and IL-4 / GM-CSF .
19651524	0	GM-CSF	88,94	IL-4	13,17	GM-CSF	IL-4	12981(Tax:10090)	16189(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Induction Induction|nmod|END_ENTITY	Induction of IL-4 release and upregulated expression of protease_activated_receptors by GM-CSF in P815 cells .
8502331	0	GM-CSF	202,208	IL-4	196,200	GM-CSF	IL-4	1437	3565	Gene	Gene	IL-3|dep|START_ENTITY IL-3|dep|END_ENTITY	New predictive protocol for therapeutic treatment of renal_and_nonrenal_anemias with recombinant human erythropoietin with a simple immunoenzymatic dosage of serum burst-promoting activity -LRB- IL-3 , IL-4 , GM-CSF -RRB-
8554685	0	GM-CSF	48,54	IL-4	23,27	GM-CSF	IL-4	1437	3565	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
9050748	0	GM-CSF	129,135	IL-4	0,4	GM-CSF	IL-4	1437	3565	Gene	Gene	production|nmod|START_ENTITY regulated|nmod|production regulated|nsubjpass|proliferation proliferation|compound|END_ENTITY	IL-4 and TNF-alpha-mediated proliferation of the human megakaryocytic line M-O7E is regulated by induced autocrine production of GM-CSF .
10490850	0	GM-CSF	77,83	IL-5	67,71	GM-CSF	IL-5	1437	3567	Gene	Gene	receptor|amod|START_ENTITY IL-3|dep|receptor Association|parataxis|IL-3 Association|nmod|END_ENTITY	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
10903977	0	GM-CSF	39,45	IL-5	84,88	GM-CSF	IL-5	12981(Tax:10090)	16191(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Murine myeloid progenitor responses to GM-CSF and eosinophil precursor responses to IL-5 represent distinct targets for downmodulation by prostaglandin_E -LRB- 2 -RRB- .
12759409	0	GM-CSF	129,135	IL-5	150,154	GM-CSF	IL-5	1437	3567	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Differential regulation of human eosinophil IL-3 , IL-5 , and GM-CSF receptor alpha-chain expression by cytokines : IL-3 , IL-5 , and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness , but up-regulate IL-3 receptor alpha expression .
18178860	0	GM-CSF	14,20	IL-5	9,13	GM-CSF	IL-5	12981(Tax:10090)	16191(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|IL-3 IL-3|dep|END_ENTITY	The IL-3 / IL-5 / GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic_airway_inflammation .
1864012	0	GM-CSF	67,73	IL-5	11,15	GM-CSF	IL-5	1437	3567	Gene	Gene	colony-stimulating_factor|appos|START_ENTITY colony-stimulating_factor|amod|granulocyte/macrophage granulocyte/macrophage|amod|END_ENTITY	Effects of IL-5 , granulocyte/macrophage _ colony-stimulating_factor -LRB- GM-CSF -RRB- and IL-3 on the survival of human blood eosinophils in vitro .
9794243	0	GM-CSF	75,81	IL-5	70,74	GM-CSF	IL-5	1437	3567	Gene	Gene	family|amod|START_ENTITY END_ENTITY|dep|family	Regulation of proliferation , differentiation and survival by the IL-3 / IL-5 / GM-CSF receptor family .
10601562	0	GM-CSF	9,15	IL-6	56,60	GM-CSF	IL-6	12981(Tax:10090)	16193(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY upregulate|nsubj|levels upregulate|dobj|production production|compound|END_ENTITY	Elevated GM-CSF levels in tumor bearing mice upregulate IL-6 production by B cells via a mechanism independent of TNF-alpha .
15271376	0	GM-CSF	53,59	IL-6	20,24	GM-CSF	IL-6	12981(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Orally administered IL-6 induces elevated intestinal GM-CSF gene expression and splenic_CFU-GM .
23886206	0	GM-CSF	129,135	IL-6	110,114	GM-CSF	IL-6	12981(Tax:10090)	16193(Tax:10090)	Gene	Gene	IL-2|acl|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
8552986	0	GM-CSF	165,171	IL-6	118,122	GM-CSF	IL-6	1437	3569	Gene	Gene	START_ENTITY|nsubj|Adhesion Adhesion|nmod|erythrocytes erythrocytes|dep|G-CSF G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8554685	0	GM-CSF	48,54	IL-6	29,33	GM-CSF	IL-6	1437	3569	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
8552986	0	GM-CSF	165,171	IL-8	124,128	GM-CSF	IL-8	1437	3576	Gene	Gene	START_ENTITY|nsubj|Adhesion Adhesion|nmod|erythrocytes erythrocytes|dep|G-CSF G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
3139430	0	GM-CSF	98,104	IL3	39,42	GM-CSF	IL3	12981(Tax:10090)	16187(Tax:10090)	Gene	Gene	interleukin_3|appos|START_ENTITY interleukin_3|appos|END_ENTITY	Selective production of interleukin_3 -LRB- IL3 -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in vitro by murine L3T4 + T cells : lack of spontaneous IL3 and GM-CSF production by Ly-2 - / L3T4 - lpr subset .
9850165	0	GM-CSF	82,88	Il6	20,23	GM-CSF	Il6	12981(Tax:10090)	16193(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|expression expression|amod|END_ENTITY	CSF-1 regulation of Il6 gene expression by murine macrophages : a pivotal role for GM-CSF .
1370208	0	GM-CSF	48,54	M-CSF	89,94	GM-CSF	M-CSF	1437	1435	Gene	Gene	expression|nmod|START_ENTITY downregulate|dobj|expression downregulate|dep|not not|nmod|END_ENTITY	Glucocorticoids downregulate gene expression of GM-CSF , NAP-1 / IL-8 , and IL-6 , but not of M-CSF in human fibroblasts .
15358207	0	GM-CSF	0,6	M-CSF	29,34	GM-CSF	M-CSF	1437	1435	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	GM-CSF can not substitute for M-CSF in human osteoclastogenesis .
1623556	0	GM-CSF	109,115	M-CSF	52,57	GM-CSF	M-CSF	1437	1435	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Production Production|nmod|macrophage_colony-stimulating_factor macrophage_colony-stimulating_factor|appos|END_ENTITY	Production of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- by human monocytes is differentially regulated by GM-CSF , TNF_alpha , and IFN-gamma .
1701692	0	GM-CSF	96,102	M-CSF	18,23	GM-CSF	M-CSF	12981(Tax:10090)	12977(Tax:10090)	Gene	Gene	actions|nmod|START_ENTITY controlled|nmod|actions controlled|nsubjpass|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of the M-CSF receptor is controlled posttranscriptionally by the dominant actions of GM-CSF or multi-CSF .
25202910	0	GM-CSF	0,6	M-CSF	72,77	GM-CSF	M-CSF	12981(Tax:10090)	12977(Tax:10090)	Gene	Gene	treated|nsubj|START_ENTITY treated|ccomp|improve improve|xcomp|similar similar|nmod|macrophages macrophages|amod|END_ENTITY	GM-CSF treated F4/80 + BMCs improve murine hind_limb_ischemia similar to M-CSF differentiated macrophages .
7858491	0	GM-CSF	40,46	M-CSF	54,59	GM-CSF	M-CSF	1437	1435	Gene	Gene	configuration|nmod|START_ENTITY configuration|appos|receptor receptor|amod|END_ENTITY	Expression and genomic configuration of GM-CSF , IL-3 , M-CSF receptor -LRB- C-FMS -RRB- , early_growth_response_gene-1 _ -LRB- EGR-1 -RRB- and M-CSF genes in primary myelodysplastic_syndromes .
7884321	0	GM-CSF	177,183	M-CSF	116,121	GM-CSF	M-CSF	1437	1435	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	Differential regulation of fyn-associated protein tyrosine kinase activity by macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
26559469	0	GM-CSF	84,90	MMP-2	98,103	GM-CSF	MMP-2	493805(Tax:9685)	101098838	Gene	Gene	TGF-b|compound|START_ENTITY TGF-b|appos|END_ENTITY	Gene expression profiles of some cytokines , growth factors , receptors , and enzymes -LRB- GM-CSF , IFNy , MMP-2 , IGF-II , EGF , TGF-b , IGF-IIR -RRB- during pregnancy in the cat uterus .
2835725	0	GM-CSF	43,49	Myeloperoxidase	0,15	GM-CSF	Myeloperoxidase	1437	4353	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Myeloperoxidase and oncogene expression in GM-CSF induced bone marrow differentiation .
24142153	0	GM-CSF	33,39	Ovalbumin	0,9	GM-CSF	Ovalbumin	12981(Tax:10090)	282665(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Ovalbumin enhances YKL-40 , IL-5 , GM-CSF , and eotaxin expression simultaneously in primarily cultured mouse tracheal epithelial cells .
21865551	0	GM-CSF	128,134	P2X7_receptor	4,17	GM-CSF	P2X7 receptor	12981(Tax:10090)	18439(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The P2X7_receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF .
16202975	0	GM-CSF	25,31	PI3-kinase	0,10	GM-CSF	PI3-kinase	1437	5296	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	PI3-kinase activation by GM-CSF in endothelium is upstream of Jak/Stat pathway : role of alphaGMR .
10490850	0	GM-CSF	77,83	RACK1	15,20	GM-CSF	RACK1	1437	10399	Gene	Gene	receptor|amod|START_ENTITY IL-3|dep|receptor Association|parataxis|IL-3 Association|nmod|END_ENTITY	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
20439113	0	GM-CSF	49,55	RUNX1	68,73	GM-CSF	RUNX1	1437	861	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1 .
15363038	0	GM-CSF	0,6	RhoA	17,21	GM-CSF	RhoA	1437	387	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	GM-CSF activates RhoA , integrin and MMP expression in human monocytic cells .
11858824	0	GM-CSF	146,152	SHP-1	92,97	GM-CSF	SHP-1	1437	5777	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|dobj|END_ENTITY	Molecular assembly of CD46 with CD9 , alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF .
26123499	0	GM-CSF	15,21	STAT4	0,5	GM-CSF	STAT4	12981(Tax:10090)	20849(Tax:10090)	Gene	Gene	production|amod|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE .
24258001	0	GM-CSF	16,22	TGF-b1	26,32	GM-CSF	TGF-b1	1437	7040	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of GM-CSF by TGF-b1 in epithelial mesenchymal transition of human HERS/ERM cells .
8552986	0	GM-CSF	165,171	TGF_beta	137,145	GM-CSF	TGF beta	1437	7040	Gene	Gene	START_ENTITY|nsubj|Adhesion Adhesion|nmod|erythrocytes erythrocytes|dep|G-CSF G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
1387891	0	GM-CSF	24,30	TNF	0,3	GM-CSF	TNF	1437	7124	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages .
9182888	0	GM-CSF	117,123	TNF-alpha	52,61	GM-CSF	TNF-alpha	1437	7124	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	The priming action of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on neutrophils activated by inflammatory microcrystals .
9450626	0	GM-CSF	91,97	TNF-alpha	118,127	GM-CSF	TNF-alpha	1437	7124	Gene	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Modulation of MHC class II + Langerhans cell numbers in corticosteroid treated epidermis by GM-CSF in combination with TNF-alpha .
8552986	0	GM-CSF	165,171	TNF_alpha	147,156	GM-CSF	TNF alpha	1437	7124	Gene	Gene	START_ENTITY|nsubj|Adhesion Adhesion|nmod|erythrocytes erythrocytes|dep|G-CSF G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
21884837	0	GM-CSF	72,78	TNFa	0,4	GM-CSF	TNFa	1437	7124	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	TNFa inhibits the development of osteoclasts through osteoblast-derived GM-CSF .
15622623	0	GM-CSF	1,7	Vp16	22,26	GM-CSF	Vp16	1437	3054	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	-LSB- GM-CSF regulates the Vp16 induced leukemic cell apoptosis -RSB- .
11459101	0	GM-CSF	6,12	alpha-chain	34,45	GM-CSF	alpha-chain	1437	2217	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Human GM-CSF interaction with the alpha-chain of its receptor studied using surface plasmon resonance .
14525945	0	GM-CSF	21,27	arginase-1	75,85	GM-CSF	arginase-1	1437	383	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity , MCP-1 expression , and matrix_metalloproteinase-12 : a potential role during arteriogenesis .
8972491	0	GM-CSF	78,84	beta_c	4,10	GM-CSF	beta c	12981(Tax:10090)	12983(Tax:10090)	Gene	Gene	interleukin_3|appos|START_ENTITY component|nmod|interleukin_3 component|amod|END_ENTITY	The beta_c component of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / interleukin_3 -LRB- IL-3 -RRB- / IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression .
17507085	0	GM-CSF	14,20	c-Maf	60,65	GM-CSF	c-Maf	1437	4094	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of GM-CSF expression by the transcription factor c-Maf .
3071340	0	GM-CSF	8,14	c-fos	58,63	GM-CSF	c-fos	1437	2353	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of GM-CSF in phagocyte recruitment and regulation of c-fos protooncogene expression .
12871843	0	GM-CSF	58,64	c-jun_N-terminal_kinase	8,31	GM-CSF	c-jun N-terminal kinase	1437	5599	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Role of c-jun_N-terminal_kinase in the induced release of GM-CSF , RANTES and IL-8 from human airway smooth muscle cells .
8809409	0	GM-CSF	14,20	core-binding_factor	43,62	GM-CSF	core-binding factor	1437	10153	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of GM-CSF gene transcription by core-binding_factor .
10374451	0	GM-CSF	15,21	endothelin-1	25,37	GM-CSF	endothelin-1	1437	1906	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- The effect of GM-CSF on endothelin-1 and endothelin_converting_enzyme gene expression in human airway smooth muscle cells with or without theophylline incubation -RSB- .
22912784	0	GM-CSF	55,61	epidermal_growth_factor_receptor	102,134	GM-CSF	epidermal growth factor receptor	1437	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Proteasome inhibition augments cigarette smoke-induced GM-CSF expression in trophoblast cells via the epidermal_growth_factor_receptor .
16734558	0	GM-CSF	63,69	gag	26,29	GM-CSF	gag	1437	17276(Tax:10090)	Gene	Gene	delivery|nmod|START_ENTITY END_ENTITY|nmod|delivery	Enhancing efficacy of HIV gag DNA vaccine by local delivery of GM-CSF in murine and macaque models .
12225397	0	GM-CSF	0,6	gp91phox	29,37	GM-CSF	gp91phox	1437	1536	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	GM-CSF induces expression of gp91phox and stimulates retinoic_acid-induced p47phox expression in human myeloblastic_leukemia cells .
10231951	0	GM-CSF	64,70	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	281095(Tax:9913)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Expression of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor on B-1a cell from persistent_lymphocytosis -LRB- PL -RRB- cows and lymphoma cell induced by bovine_leukemia_virus .
11876989	0	GM-CSF	188,194	granulocyte-macrophage_colony-stimulating_factor	138,186	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Mobilization of autologous peripheral blood stem cells by chemotherapy and recombinant granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- -RSB- .
12047622	0	GM-CSF	65,71	granulocyte-macrophage_colony-stimulating_factor	15,63	GM-CSF	granulocyte-macrophage colony-stimulating factor	116630(Tax:10116)	116630(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in pregnancy-enhanced sleep .
1387006	0	GM-CSF	79,85	granulocyte-macrophage_colony-stimulating_factor	29,77	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Biochemical effects of human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on the human neutrophil .
1535090	0	GM-CSF	67,73	granulocyte-macrophage_colony-stimulating_factor	17,65	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Up-regulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors in murine peritoneal exudate macrophages by both GM-CSF and IL-3 .
1581405	0	GM-CSF	113,119	granulocyte-macrophage_colony-stimulating_factor	63,111	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A randomized phase-I/II multicenter study of recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- therapy for patients with myelodysplastic_syndromes and a relatively low risk of acute_leukemia .
1772663	0	GM-CSF	76,82	granulocyte-macrophage_colony-stimulating_factor	26,74	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The in situ expression of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- mRNA at the maternal-fetal interface .
21515681	0	GM-CSF	113,119	granulocyte-macrophage_colony-stimulating_factor	63,111	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	1437	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- domain induces enhanced antibody and T cell responses .
23565193	0	GM-CSF	110,116	granulocyte-macrophage_colony-stimulating_factor	60,108	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Chimeric_HIV-1_envelope_glycoproteins with potent intrinsic granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- activity .
3071331	0	GM-CSF	88,94	granulocyte-macrophage_colony-stimulating_factor	38,86	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Phase I/II study of recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in bone_marrow_failure .
3546340	0	GM-CSF	87,93	granulocyte-macrophage_colony-stimulating_factor	37,85	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Internalisation and recycling of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor on a murine myelomonocytic_leukemia .
6446568	0	GM-CSF	87,93	granulocyte-macrophage_colony-stimulating_factor	37,85	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Secretion and partial degradation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- of mouse L-P3 cells .
6969262	0	GM-CSF	78,84	granulocyte-macrophage_colony-stimulating_factor	28,76	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	X-ray-induced production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- by mouse spleen cells in culture .
7577656	0	GM-CSF	88,94	granulocyte-macrophage_colony-stimulating_factor	38,86	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interferon-alpha -LRB- IFN-alpha -RRB- inhibits granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- expression at the post-transcriptional level in murine bone marrow stromal cells .
7585565	0	GM-CSF	64,70	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- activity by suramin and suramin analogues is correlated to interaction with the GM-CSF nucleotide-binding site .
7723402	0	GM-CSF	96,102	granulocyte-macrophage_colony-stimulating_factor	24,72	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	In vivo effect of human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on neutrophil GM-CSF receptors .
8429224	0	GM-CSF	102,108	granulocyte-macrophage_colony-stimulating_factor	52,100	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	An immunoenzyme technique for the identification of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors using digoxigenated-GM-CSF .
8436602	0	GM-CSF	66,72	granulocyte-macrophage_colony-stimulating_factor	16,64	GM-CSF	granulocyte-macrophage colony-stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Deregulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor in murine macrophage cell line J774A .1 .
8543141	0	GM-CSF	84,90	granulocyte-macrophage_colony-stimulating_factor	34,82	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Polymorphism at codon 117 of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- gene -RSB- .
8641372	0	GM-CSF	64,70	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Regulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors in a GM-CSF-dependent human myeloid_leukemia cell line -LRB- AML-193 -RRB- by interleukin-6 .
8871874	0	GM-CSF	64,70	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on hepatitis_B vaccination in haemodialysis patients .
9242533	0	GM-CSF	101,107	granulocyte-macrophage_colony-stimulating_factor	51,99	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	responses|dep|START_ENTITY responses|nmod|END_ENTITY	Hematopoietic and lymphopoietic responses in human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor transgenic_mice injected with human GM-CSF .
9376581	0	GM-CSF	60,66	granulocyte-macrophage_colony-stimulating_factor	10,58	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor exists as a preformed receptor complex that can be activated by GM-CSF , interleukin-3 , or interleukin-5 .
9423810	0	GM-CSF	61,67	granulocyte-macrophage_colony-stimulating_factor	11,59	GM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on neutrophil kinetics and function in normal human volunteers .
11529909	0	GM-CSF	61,67	granulocyte-macrophage_colony_stimulating_factor	11,59	GM-CSF	granulocyte-macrophage colony stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in vivo on cytokine production and proliferation by spleen cells .
17453257	0	GM-CSF	99,105	granulocyte-macrophage_colony_stimulating_factor	49,97	GM-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and purification of recombinant human granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- from high cell density cultures of Pichia_pastoris .
17894541	0	GM-CSF	110,116	granulocyte-macrophage_colony_stimulating_factor	60,108	GM-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Increased granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary_fibrosis .
2276111	0	GM-CSF	72,78	granulocyte-macrophage_colony_stimulating_factor	22,70	GM-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The potential role of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in cancer chemotherapy .
3066673	0	GM-CSF	68,74	granulocyte-macrophage_colony_stimulating_factor	18,66	GM-CSF	granulocyte-macrophage colony stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of excess granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in mice infected with a GM-CSF retrovirus .
8347851	0	GM-CSF	58,64	granulocyte-macrophage_colony_stimulating_factor	8,56	GM-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- after autologous bone marrow transplantation for Hodgkin 's _ disease .
8693443	0	GM-CSF	58,64	granulocyte-macrophage_colony_stimulating_factor	8,56	GM-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in the pathogenesis of adult pulmonary_histiocytosis_X .
9013491	0	GM-CSF	61,67	granulocyte-macrophage_colony_stimulating_factor	11,59	GM-CSF	granulocyte-macrophage colony stimulating factor	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- on biomaterial-associated staphylococcal_infection in mice .
7829234	0	GM-CSF	59,65	granulocyte-monocyte_colony-stimulating_factor	11,57	GM-CSF	granulocyte-monocyte colony-stimulating factor	1437	1437	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of granulocyte-monocyte_colony-stimulating_factor -LRB- GM-CSF -RRB- on expression of adhesion molecules and production of cytokines in blood monocytes and ovarian_cancer-associated macrophages .
12206872	0	GM-CSF	76,82	granulocyte_macrophage-colony_stimulating_factor	26,74	GM-CSF	granulocyte macrophage-colony stimulating factor	1437	1437	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of endometrial granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- in the ewe .
16414253	0	GM-CSF	60,66	granulocyte_macrophage-colony_stimulating_factor	10,58	GM-CSF	granulocyte macrophage-colony stimulating factor	1437	1437	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- on 5-FU-induced ulcerative_mucositis in hamster buccal pouches .
23886206	0	GM-CSF	129,135	iNOS	90,94	GM-CSF	iNOS	12981(Tax:10090)	18126(Tax:10090)	Gene	Gene	IL-2|acl|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
1700731	0	GM-CSF	116,122	interleukin-1_and_tumor_necrosis_factor	147,186	GM-CSF	interleukin-1 and tumor necrosis factor	1437	3552;7124	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Cytokine regulation of colony-stimulating factor production in cultured human synovial fibroblasts : I. Induction of GM-CSF and G-CSF production by interleukin-1_and_tumor_necrosis_factor .
8639879	0	GM-CSF	144,150	interleukin-3	72,85	GM-CSF	interleukin-3	12981(Tax:10090)	16187(Tax:10090)	Gene	Gene	IL-3|appos|START_ENTITY IL-3|amod|END_ENTITY	Extracellular truncations of h beta_c , the common signaling subunit for interleukin-3 -LRB- IL-3 -RRB- , granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , and IL-5 , lead to ligand-independent activation .
8574170	0	GM-CSF	14,20	interleukin-4	53,66	GM-CSF	interleukin-4	1437	3565	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Inhibition of GM-CSF production by recombinant human interleukin-4 : negative regulator of hematopoiesis .
18432817	0	GM-CSF	72,78	interleukin_3	15,28	GM-CSF	interleukin 3	1437	3562	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|END_ENTITY	Measurement of interleukin_3 and other hematopoietic cytokines , such as GM-CSF , G-CSF , M-CSF , erythropoietin , steel_factor , and Flt-3_ligand .
23105194	0	GM-CSF	135,141	myeloperoxidase	15,30	GM-CSF	myeloperoxidase	1437	4353	Gene	Gene	Granulocyte_Macrophage_Colony_Stimulating_Factor|appos|START_ENTITY treated|nmod|Granulocyte_Macrophage_Colony_Stimulating_Factor treated|nsubj|Enhancement Enhancement|nmod|activity activity|amod|END_ENTITY	Enhancement of myeloperoxidase activity in WBCS in oral_cancer patients treated with Granulocyte_Macrophage_Colony_Stimulating_Factor -LRB- GM-CSF -RRB- - A pilot study .
8246607	0	GM-CSF	15,21	myeloperoxidase	25,40	GM-CSF	myeloperoxidase	1437	4353	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|release release|amod|END_ENTITY	The effects of GM-CSF on myeloperoxidase release in normal and myelodysplastic neutrophils .
9802884	0	GM-CSF	0,6	ovalbumin	61,70	GM-CSF	ovalbumin	12981(Tax:10090)	282665(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY allows|nsubj|expression allows|dobj|END_ENTITY	GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice .
1704845	0	GM-CSF	51,57	stem_cell_factor	18,34	GM-CSF	stem cell factor	1437	4254	Gene	Gene	synergises|nmod|START_ENTITY synergises|nsubj|END_ENTITY	Recombinant human stem_cell_factor synergises with GM-CSF , G-CSF , IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages .
21220694	0	GM-CSFR	39,46	Src-like_adaptor_protein	4,28	GM-CSFR	Src-like adaptor protein	1438	6503	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	The Src-like_adaptor_protein regulates GM-CSFR signaling and monocytic dendritic cell maturation .
1391803	0	GM-CSF_and_IL-3	30,45	G-CSF	23,28	GM-CSF and IL-3	G-CSF	1440;1437;3562	1440	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Comparative effects of G-CSF , GM-CSF_and_IL-3 on cytosine_arabinoside - and daunorubicin-mediated cytotoxicity of acute_myeloid_leukemia cells and normal myeloid progenitors .
18753612	0	GM1	12,15	SVS2	51,55	GM1	SVS2	210582(Tax:10090)	53878(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Ganglioside GM1 mediates decapacitation effects of SVS2 on murine spermatozoa .
9753325	0	GM130	65,70	Cdc2	0,4	GM130	Cdc2	2801	983	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|kinase kinase|amod|END_ENTITY	Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi_fragmentation in mitosis .
26083584	0	GM130	30,35	FMNL1	14,19	GM130	FMNL1	99412(Tax:10090)	57778(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RhoA-mediated FMNL1 regulates GM130 for actin assembly and phosphorylates MAPK for spindle formation in mouse oocyte meiosis .
26165940	0	GM130	0,5	TPX2	61,65	GM130	TPX2	2801	22974	Gene	Gene	Assembly|compound|START_ENTITY Assembly|nmod|END_ENTITY	GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules .
15037601	0	GM130	46,51	YSK1	0,4	GM130	YSK1	2801	10494	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta .
7713516	0	GM2	28,31	Gm2a	51,55	GM2	Gm2a	192986(Tax:10090)	14667(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The mouse gene encoding the GM2 activator protein -LRB- Gm2a -RRB- : cDNA sequence , expression , and chromosome mapping .
1645342	0	GM3	24,27	epidermal_growth_factor	51,74	GM3	epidermal growth factor	110204(Tax:10090)	1950	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Effects of gangliosides GM3 and De-N-acetyl_GM3 on epidermal_growth_factor receptor kinase activity and cell growth .
26729095	0	GM3_Synthase	32,44	Runx2	88,93	GM3 Synthase	Runx2	8869	860	Gene	Gene	Mediated|nsubjpass|START_ENTITY Mediated|nmod|END_ENTITY	Serum Deprivation-Induced Human GM3_Synthase -LRB- hST3Gal_V -RRB- Gene Expression Is Mediated by Runx2 in Human Osteoblastic MG-63 Cells .
2302211	0	GM3_synthase	72,84	GD3_synthase	31,43	GM3 synthase	GD3 synthase	83505(Tax:10116)	25280(Tax:10116)	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification to homogeneity of GD3_synthase and partial purification of GM3_synthase from rat brain .
21072492	0	GM3_synthase	73,85	TNF-a	64,69	GM3 synthase	TNF-a	8869	7124	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Suppression of vascular smooth muscle cell responses induced by TNF-a in GM3_synthase gene transfected cells .
23444385	0	GMAP210	38,45	SQL-1	0,5	GMAP210	SQL-1	9321	190949(Tax:6239)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	SQL-1 , homologue of the Golgi protein GMAP210 , modulates intraflagellar transport in C. _ elegans .
26230539	0	GMCSF	40,45	GMCSF	74,79	GMCSF	GMCSF	1437	1437	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Antiapoptotic Effect of Highly Secreted GMCSF From Neuronal Cell-specific GMCSF Overexpressing Neural Stem Cells in Spinal_Cord_Injury Model .
26230539	0	GMCSF	74,79	GMCSF	40,45	GMCSF	GMCSF	1437	1437	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Antiapoptotic Effect of Highly Secreted GMCSF From Neuronal Cell-specific GMCSF Overexpressing Neural Stem Cells in Spinal_Cord_Injury Model .
2834073	0	GMCSF	144,149	IFN-gamma	79,88	GMCSF	IFN-gamma	1437	3458	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	A novel human macrophage-activating_factor : distinction from interferon-gamma -LRB- IFN-gamma -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GMCSF -RRB- .
12637324	0	GMCSF	0,5	NF-kappaB	16,25	GMCSF	NF-kappaB	1437	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta .
12637324	0	GMCSF	56,61	NF-kappaB	16,25	GMCSF	NF-kappaB	1437	4790	Gene	Gene	receptor|compound|START_ENTITY interaction|nmod|receptor END_ENTITY|nmod|interaction	GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta .
16086184	0	GMIP	29,33	Gem_interacting_protein	4,27	GMIP	Gem interacting protein	51291	51291	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The Gem_interacting_protein -LRB- GMIP -RRB- gene is associated with major depressive_disorder .
16262247	0	GMP	14,17	GluR2	25,30	GMP	GluR2	22978	2891	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Binding of 5 ' - GMP to the GluR2 AMPA receptor : insight from targeted_molecular_dynamics simulations .
15084592	0	GMP	56,59	transglutaminase_3	21,39	GMP	transglutaminase 3	22978	7053	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of transglutaminase_3 in complex with GMP : structural basis for nucleotide specificity .
1721534	0	GMP-140	18,25	CD62	27,31	GMP-140	CD62	6403	6403	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Downregulation of GMP-140 -LRB- CD62 or PADGEM -RRB- expression on platelets by N,N-dimethyl and N,N,N-trimethyl derivatives of sphingosine .
1378365	0	GMP-140	105,112	ICAM-1	153,159	GMP-140	ICAM-1	6403	3383	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Adhesion molecule expression in Graves ' thyroid glands ; potential relevance of granule membrane protein -LRB- GMP-140 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the homing and antigen presentation processes .
1372646	0	GMP-140	20,27	P-selectin	29,39	GMP-140	P-selectin	6403	6403	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of GMP-140 -LRB- P-selectin -RRB- as a circulating plasma protein .
8579578	0	GMP-140	66,73	P-selectin	54,64	GMP-140	P-selectin	6403	6403	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Cross-linking_of_the_ninth_consensus repeat domain of P-selectin -LRB- GMP-140 , CD62P -RRB- with a monoclonal antibody enhanced leukocyte adhesive activity .
2480118	0	GMP-140	35,42	heparin-binding_protein	48,71	GMP-140	heparin-binding protein	6403	566	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human platelet GMP-140 as a heparin-binding_protein .
11110714	0	GMPS	85,89	MLL	72,75	GMPS	MLL	8833	4297	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	t -LRB- 3 ; 11 -RRB- translocation in treatment-related acute_myeloid_leukemia fuses MLL with the GMPS -LRB- GUANOSINE 5 ' MONOPHOSPHATE SYNTHETASE -RRB- gene .
19995917	0	GMP_synthetase	20,34	ubiquitin-specific_protease_7	51,80	GMP synthetase	ubiquitin-specific protease 7	45830(Tax:7227)	32169(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Biosynthetic enzyme GMP_synthetase cooperates with ubiquitin-specific_protease_7 in transcriptional regulation of ecdysteroid target genes .
12759536	0	GNA11	22,27	MCT1	45,49	GNA11	MCT1	2767	6566	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of GNA11 and silencing of MCT1 in human breast_cancers .
8886169	0	GNAL	48,52	G-olf_alpha	35,46	GNAL	G-olf alpha	2774	2774	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Linkage disequilibrium analysis of G-olf_alpha -LRB- GNAL -RRB- in bipolar_affective_disorder .
21487925	0	GNAQ	9,13	AKT3	21,25	GNAQ	AKT3	2776	10000	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Uncommon GNAQ , MMP8 , AKT3 , EGFR , and PIK3R1 mutations in thyroid_cancers .
8825633	0	GNAQ	94,98	G_alpha_q	78,87	GNAQ	G alpha q	2776	2776	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of human G_alpha_q cDNA and chromosomal localization of the G_alpha_q gene -LRB- GNAQ -RRB- and a processed pseudogene .
17720980	0	GNAQ	42,46	Galphaq	33,40	GNAQ	Galphaq	2776	2776	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A functional polymorphism of the Galphaq -LRB- GNAQ -RRB- gene is associated with accelerated mortality in African-American heart_failure .
21487925	0	GNAQ	9,13	MMP8	15,19	GNAQ	MMP8	2776	4317	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Uncommon GNAQ , MMP8 , AKT3 , EGFR , and PIK3R1 mutations in thyroid_cancers .
16442859	0	GNAS	34,38	Runx2	0,5	GNAS	Runx2	2778	860	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Runx2 regulates the expression of GNAS on SaOs-2 cells .
11836449	0	GNAS1	36,41	Gsalpha	43,50	GNAS1	Gsalpha	2778	2778	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	An R201H activating mutation of the GNAS1 -LRB- Gsalpha -RRB- gene in a corticotroph pituitary adenoma .
12656668	0	GNAS1	58,63	Gsalpha	49,56	GNAS1	Gsalpha	2778	2778	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new heterozygous mutation -LRB- L338N -RRB- in the human Gsalpha -LRB- GNAS1 -RRB- gene as a cause for congenital_hypothyroidism in Albright 's _ hereditary_osteodystrophy .
15019160	0	GNB3	62,66	G-protein_beta-3_subunit	31,55	GNB3	G-protein beta-3 subunit	2784	2784	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The 825C > T polymorphism of the G-protein_beta-3_subunit gene -LRB- GNB3 -RRB- and breast_cancer .
11008983	0	GNB3	30,34	G-protein_beta3	0,15	GNB3	G-protein beta3	2784	2784	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	G-protein_beta3 subunit gene -LRB- GNB3 -RRB- polymorphism 825C -- > T in patients with hypertensive crisis .
16513451	0	GNB3	186,190	G-protein_beta3	161,176	GNB3	G-protein beta3	2784	2784	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The angiotensin_II receptor antagonist valsartan inhibits endothelin_1-induced vasoconstriction in the skin microcirculation in humans in vivo : influence of the G-protein_beta3 subunit -LRB- GNB3 -RRB- C825T polymorphism .
9856980	0	GNB3	30,34	G-protein_beta3	0,15	GNB3	G-protein beta3	2784	2784	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	G-protein_beta3 subunit gene -LRB- GNB3 -RRB- variant in causation of essential hypertension .
14586390	0	GNB3	128,132	G_protein_beta3	98,113	GNB3	G protein beta3	2784	2784	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Venous response to nitroglycerin is enhanced in young , healthy carriers of the 825T allele of the G_protein_beta3 subunit gene -LRB- GNB3 -RRB- .
14692527	0	GNB3	71,75	G_protein_beta3	49,64	GNB3	G protein beta3	2784	2784	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The CC genotype of the C825T polymorphism of the G_protein_beta3 gene -LRB- GNB3 -RRB- is associated with a high relapse rate in patients with chronic_lymphocytic_leukaemia .
12576843	0	GNB3	66,70	G_protein_beta_3	41,57	GNB3	G protein beta 3	2784	2784	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Sildenafil response is influenced by the G_protein_beta_3 subunit GNB3 C825T polymorphism : a pilot study .
19692333	0	GNBP3	69,74	Gram-negative_binding_protein_3	36,67	GNBP3	Gram-negative binding protein 3	39020(Tax:7227)	39020(Tax:7227)	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The N-terminal domain of Drosophila Gram-negative_binding_protein_3 -LRB- GNBP3 -RRB- defines a novel family of fungal pattern recognition receptors .
27037841	0	GNE	34,37	GNE	57,60	GNE	GNE	10020	10020	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Aberrant O-GlcNAcylation disrupts GNE enzyme activity in GNE myopathy .
27037841	0	GNE	57,60	GNE	34,37	GNE	GNE	10020	10020	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Aberrant O-GlcNAcylation disrupts GNE enzyme activity in GNE myopathy .
7606925	0	GNG5	62,66	G-protein_gamma_5_subunit	35,60	GNG5	G-protein gamma 5 subunit	2787	2787	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Lysosomal chitobiase -LRB- CTB -RRB- and the G-protein_gamma_5_subunit -LRB- GNG5 -RRB- genes co-localize to human chromosome 1p22 .
9283045	0	GNRH	85,89	gonadotropin_releasing_hormone	53,83	GNRH	gonadotropin releasing hormone	2796	2796	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	The interactive language of the hypothalamus for the gonadotropin_releasing_hormone -LRB- GNRH -RRB- system .
19357364	0	GNRH1	16,21	follicle-stimulating_hormone_beta	25,58	GNRH1	follicle-stimulating hormone beta	14714(Tax:10090)	14308(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Rapid effect of GNRH1 on follicle-stimulating_hormone_beta gene expression in LbetaT2 mouse pituitary cells requires the progesterone_receptor .
19291786	0	GOLPH2	24,30	Golgi_phosphoprotein_2	0,22	GOLPH2	Golgi phosphoprotein 2	51280	51280	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Golgi_phosphoprotein_2 -LRB- GOLPH2 -RRB- expression in liver_tumors and its value as a serum marker in hepatocellular_carcinomas .
23345592	0	GOLPH3	20,26	GOLPH3L	0,7	GOLPH3	GOLPH3L	64083	55204	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	GOLPH3L antagonizes GOLPH3 to determine Golgi morphology .
23345592	0	GOLPH3L	0,7	GOLPH3	20,26	GOLPH3L	GOLPH3	55204	64083	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	GOLPH3L antagonizes GOLPH3 to determine Golgi morphology .
22178155	0	GOOSECOID	86,95	EVEN-SKIPPED_HOMEOBOX_1	0,23	GOOSECOID	EVEN-SKIPPED HOMEOBOX 1	145258	2128	Gene	Gene	expression|amod|START_ENTITY repressing|dobj|expression controls|advcl|repressing controls|nsubj|END_ENTITY	EVEN-SKIPPED_HOMEOBOX_1 controls human ES cell differentiation by directly repressing GOOSECOID expression .
18792902	0	GOx	64,67	glucose_oxidase	47,62	GOx	glucose oxidase	54363	54363	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	A new route to the considerable enhancement of glucose_oxidase -LRB- GOx -RRB- activity : the simple assembly of a complex from CdTe quantum dots and GOx , and its glucose sensing .
10708050	0	GP120	38,43	CD4	105,108	GP120	CD4	3700	920	Gene	Gene	T-helper|compound|START_ENTITY peptides|nmod|T-helper epitope|nsubj|peptides epitope|xcomp|antagonize antagonize|dobj|response response|nmod|clones clones|compound|END_ENTITY	Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones .
11906183	0	GP120	28,33	CD4	8,11	GP120	CD4	3700	920	Gene	Gene	utilization|compound|START_ENTITY hinge|nmod|utilization hinge|nsubj|Role Role|nmod|END_ENTITY	Role of CD4 hinge region in GP120 utilization by immunoglobulin domain 1 .
3264307	0	GP120	20,25	CD4	37,40	GP120	CD4	3700	920	Gene	Gene	Characterization|nmod|START_ENTITY binding|nsubj|Characterization binding|nmod|END_ENTITY	Characterization of GP120 binding to CD4 and an assay that measures ability of sera to inhibit this binding .
11195003	0	GP130	0,5	IL-6	52,56	GP130	IL-6	3572	3569	Gene	Gene	signalling|compound|START_ENTITY signalling|acl|initiated initiated|nmod|complex complex|compound|END_ENTITY	GP130 and c-kit signalling , initiated by the sIL-6R / IL-6 complex , is insufficient to expand the primitive adult bone marrow CD34 + CD38 - pre-CFU cell .
24456369	0	GP130	201,206	IL-6	196,200	GP130	IL-6	3572	3569	Gene	Gene	interface|compound|START_ENTITY interface|compound|END_ENTITY	Drug design targeting protein-protein interactions -LRB- PPIs -RRB- using multiple ligand simultaneous docking -LRB- MLSD -RRB- and drug repositioning : discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6 / GP130 interface .
19919903	0	GP2	102,105	glycoprotein_2	86,100	GP2	glycoprotein 2	2813	2813	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The c. 1275A > G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein_2 -LRB- GP2 -RRB- gene decreases exon 9 inclusion .
3198118	0	GP2B	29,33	GPIIb	35,40	GP2B	GPIIb	3674	3674	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of human platelet GP2B -LRB- GPIIb -RRB- gene to chromosome 17 , region q21.1-q21 .3 .
25938831	0	GP73	45,49	Golgi_protein-73	27,43	GP73	Golgi protein-73	51280	51280	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	-LSB- Diagnostic value of serum Golgi_protein-73 -LRB- GP73 -RRB- combined with AFP-L3 % in hepatocellular_carcinoma : a meta-analysis -RSB- .
22316048	0	GP88	13,17	Progranulin	0,11	GP88	Progranulin	2896	2896	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Progranulin -LRB- GP88 -RRB- tumor tissue expression is associated with increased risk of recurrence in breast_cancer patients diagnosed with estrogen receptor positive invasive_ductal_carcinoma .
22280843	0	GPA-14	85,91	DOP-2	53,58	GPA-14	DOP-2	172269(Tax:6239)	179347(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Caenorhabditis_elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14 , a Gai subunit .
12837948	0	GPA1	89,93	AtPirin1	37,45	GPA1	AtPirin1	817170(Tax:3702)	825091(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Arabidopsis cupin domain protein AtPirin1 interacts with the G_protein_alpha-subunit GPA1 and regulates seed germination and early seedling development .
17322342	0	GPA1	10,14	GCR1	4,8	GPA1	GCR1	817170(Tax:3702)	841247(Tax:3702)	Gene	Gene	chain|appos|START_ENTITY chain|compound|END_ENTITY	The GCR1 , GPA1 , PRN1 , NF-Y signal chain mediates both blue light and abscisic_acid responses in Arabidopsis .
22087143	0	GPC3	128,132	AFP	123,126	GPC3	AFP	2719	174	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Clinical values of AFP , GPC3 mRNA in peripheral blood for prediction of hepatocellular_carcinoma recurrence following OLT : AFP , GPC3 mRNA for prediction of HCC .
11193214	0	GPC3	12,16	Glypican-3	0,10	GPC3	Glypican-3	2719	2719	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glypican-3 -LRB- GPC3 -RRB- expression in human placenta : localization to the differentiated syncytiotrophoblast .
17350117	0	GPC3	49,53	Glypican_3	37,47	GPC3	Glypican 3	2719	2719	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	In vivo footprinting analysis of the Glypican_3 -LRB- GPC3 -RRB- promoter region in neuroblastoma cells .
25129460	0	GPC3	64,68	Huh-7	128,133	GPC3	Huh-7	2719	284424	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nsubj|gene	Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver_cancer cell lines Huh-7 .
18785116	0	GPC3	34,38	glypican-3	22,32	GPC3	glypican-3	2719	2719	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of glypican-3 -LRB- GPC3 -RRB- during human embryonic and fetal development .
26345955	0	GPC3	39,43	glypican-3	27,37	GPC3	glypican-3	2719	2719	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of glypican-3 -LRB- GPC3 -RRB- in lung_squamous_cell_carcinoma and lung_adenocarcinoma and its clinical significance .
26345955	0	GPC3	39,43	glypican-3	27,37	GPC3	glypican-3	2719	2719	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of glypican-3 -LRB- GPC3 -RRB- in lung_squamous_cell_carcinoma and lung_adenocarcinoma and its clinical significance .
11008203	0	GPC3	26,30	glypican_3	14,24	GPC3	glypican 3	2719	2719	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of glypican_3 -LRB- GPC3 -RRB- in embryonal_tumors .
15372512	0	GPC3	67,71	glypican_3	55,65	GPC3	glypican 3	2719	2719	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation analysis of the tumor suppressor PTEN and the glypican_3 -LRB- GPC3 -RRB- gene in patients diagnosed with Proteus_syndrome .
9339360	0	GPC3	139,143	glypican_3	127,137	GPC3	glypican 3	2719	2719	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5 ' - promoter and 3 ' - terminal ends of the human glypican_3 -LRB- GPC3 -RRB- gene .
9651473	0	GPC3	102,106	glypican_3	90,100	GPC3	glypican 3	2719	2719	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican_3 -LRB- GPC3 -RRB- gene .
9070915	0	GPC5	69,73	glypican-5	20,30	GPC5	glypican-5	2262	2262	Gene	Gene	localization|nmod|START_ENTITY localization|amod|END_ENTITY	Characterization of glypican-5 and chromosomal localization of human GPC5 , a new member of the glypican gene family .
24682381	0	GPC5	0,4	miR-620	42,49	GPC5	miR-620	2262	693205	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	GPC5 , a tumor suppressor , is regulated by miR-620 in lung_adenocarcinoma .
25585930	0	GPCR	125,129	C5aR	131,135	GPCR	C5aR	441931	728	Gene	Gene	Signalling|compound|START_ENTITY Signalling|appos|END_ENTITY	A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR -LRB- C5aR -RRB- Signalling .
24405750	0	GPCR	39,43	CNIH4	0,5	GPCR	CNIH4	441931	29097	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum .
24396730	0	GPCR	22,26	ERK	37,40	GPCR	ERK	442206	5594	Gene	Gene	Pathways|compound|START_ENTITY Pathways|compound|END_ENTITY	Minireview : Targeting GPCR Activated ERK Pathways for Drug Discovery .
23144692	0	GPCR	49,53	G-protein_coupled_receptor	21,47	GPCR	G-protein coupled receptor	10663	10663	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Multiple analyses of G-protein_coupled_receptor -LRB- GPCR -RRB- expression in the development of gefitinib-resistance in transforming non-small-cell_lung_cancer .
25078448	0	GPCR	71,75	G-protein_coupled_receptor	43,69	GPCR	G-protein coupled receptor	23890(Tax:10090)	23890(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Application of in utero electroporation of G-protein_coupled_receptor -LRB- GPCR -RRB- genes , for subcellular localization of hardly identifiable GPCR in mouse cerebral cortex .
20299453	0	GPCR	44,48	G_protein-coupled_receptor	16,42	GPCR	G protein-coupled receptor	151	151	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of a G_protein-coupled_receptor -LRB- GPCR -RRB- leads to attenuation of signaling by other GPCRs : experimental evidence for a spontaneous GPCR constitutive inactive form .
14522968	0	GPCR135	100,107	INSL7	28,33	GPCR135	INSL7	51289	117579	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|Identification Identification|nmod|END_ENTITY	Identification of relaxin-3 / INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135 .
15367576	0	GPCR135	62,69	relaxin-3	36,45	GPCR135	relaxin-3	51289	117579	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Pharmacological characterization of relaxin-3 / INSL7 receptors GPCR135 and GPCR142 from different mammalian species .
16679775	0	GPCR135	162,169	relaxin-3	120,129	GPCR135	relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	G-protein-coupled receptor -LRB- GPCR -RRB- -142 does not contribute to relaxin-3 binding in the mouse brain : further support that relaxin-3 is the physiological ligand for GPCR135 .
20857217	0	GPD1	91,95	glycerol-3-phosphate_dehydrogenase_1	53,89	GPD1	glycerol-3-phosphate dehydrogenase 1	100153250(Tax:9823)	100153250(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characteristics and expression profiles of glycerol-3-phosphate_dehydrogenase_1 -LRB- GPD1 -RRB- gene in pig .
17967976	0	GPD1-L	99,105	glycerol-3-phosphate_dehydrogenase_1	51,87	GPD1-L	glycerol-3-phosphate dehydrogenase 1	23171	2819	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular and functional characterization of novel glycerol-3-phosphate_dehydrogenase_1 like gene -LRB- GPD1-L -RRB- mutations in sudden_infant_death_syndrome .
17967977	0	GPD1-L	60,66	glycerol-3-phosphate_dehydrogenase_1	12,48	GPD1-L	glycerol-3-phosphate dehydrogenase 1	23171	2819	Gene	Gene	Mutation|appos|START_ENTITY Mutation|nmod|gene gene|amod|END_ENTITY	Mutation in glycerol-3-phosphate_dehydrogenase_1 like gene -LRB- GPD1-L -RRB- decreases cardiac Na + current and causes inherited arrhythmias .
26914403	0	GPER	40,44	FAK	46,49	GPER	FAK	2852	5747	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
26470790	0	GPER	84,88	FOXO3a	34,40	GPER	FOXO3a	2852	2309	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Estrogen-mediated inactivation of FOXO3a by the G_protein-coupled_estrogen_receptor GPER .
25204801	0	GPER	111,115	G-1	17,20	GPER	G-1	2852	5544	Gene	Gene	cells|nmod|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	The GPER agonist G-1 induces mitotic_arrest and apoptosis in human vascular smooth muscle cells independent of GPER .
26229572	0	GPER	37,41	G_Protein-Coupled_Estrogen_Receptor	0,35	GPER	G Protein-Coupled Estrogen Receptor	2852	2852	Gene	Gene	Agonist|appos|START_ENTITY Agonist|compound|END_ENTITY	G_Protein-Coupled_Estrogen_Receptor -LRB- GPER -RRB- Agonist Dual Binding Mode Analyses toward Understanding of its Activation Mechanism : A Comparative Homology Modeling Approach .
20445128	0	GPER	67,71	G_protein-coupled_estrogen_receptor_1	28,65	GPER	G protein-coupled estrogen receptor 1	171104(Tax:10116)	171104(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and signaling of G_protein-coupled_estrogen_receptor_1 -LRB- GPER -RRB- in rat sertoli cells .
26888479	0	GPER	0,4	IL-6	39,43	GPER	IL-6	2852	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	GPER negatively regulates TNFa-induced IL-6 production in human breast_cancer cells via NF-kB pathway .
22430216	0	GPER	39,43	Insulin-like_growth_factor-I	0,28	GPER	Insulin-like growth factor-I	2852	3479	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Insulin-like_growth_factor-I regulates GPER expression and function in cancer cells .
26914403	0	GPER	40,44	Src	51,54	GPER	Src	2852	6714	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
21722102	0	GPER	116,120	interleukin-10	13,27	GPER	interleukin-10	76854(Tax:10090)	16153(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of interleukin-10 in the T helper type 17 effector population by the G_protein_coupled_estrogen_receptor -LRB- GPER -RRB- agonist G-1 .
26432358	0	GPER	56,60	p38	63,66	GPER	p38	2852	1432	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Estrogen suppresses breast_cancer proliferation through GPER / p38 MAPK axis during hypoxia .
26981789	0	GPER-1	62,68	G_protein-coupled_estrogen_receptor_1	23,60	GPER-1	G protein-coupled estrogen receptor 1	2852	2852	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The protective role of G_protein-coupled_estrogen_receptor_1 -LRB- GPER-1 -RRB- on methotrexate-induced nephrotoxicity in human renal epithelium cells .
26998610	0	GPER1	49,54	GPR30	56,61	GPER1	GPR30	76854(Tax:10090)	76854(Tax:10090)	Gene	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Characterisation of Signalling by the Endogenous GPER1 -LRB- GPR30 -RRB- Receptor in an Embryonic Mouse Hippocampal Cell Line -LRB- mHippoE-18 -RRB- .
2657401	0	GPH1	22,26	glycogen_phosphorylase	46,68	GPH1	glycogen phosphorylase	856289(Tax:4932)	856289(Tax:4932)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Molecular analysis of GPH1 , the gene encoding glycogen_phosphorylase in Saccharomyces_cerevisiae .
24357227	0	GPHR	75,79	Golgi_pH_regulator	55,73	GPHR	Golgi pH regulator	36682(Tax:7227)	36682(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Mutations in the Drosophila ortholog of the vertebrate Golgi_pH_regulator -LRB- GPHR -RRB- protein disturb endoplasmic reticulum and Golgi organization and affect systemic growth .
4084208	0	GPI-1	28,33	Glucosephosphate_isomerase	0,26	GPI-1	Glucosephosphate isomerase	14751(Tax:10090)	14751(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucosephosphate_isomerase -LRB- GPI-1 -RRB- expression in mouse ova : cis regulation of monomer realization .
19726683	0	GPIHBP1	52,59	Ly6	38,41	GPIHBP1	Ly6	68453(Tax:10090)	17062(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein_lipase .
21478160	0	GPIHBP1	108,115	glycosylphosphatidylinositol-anchored_high_density_lipoprotein-binding_protein_1	26,106	GPIHBP1	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1	100759460	100759460	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Assessing the role of the glycosylphosphatidylinositol-anchored_high_density_lipoprotein-binding_protein_1 -LRB- GPIHBP1 -RRB- three-finger domain in binding lipoprotein_lipase .
10195947	0	GPIIIa	58,64	PlA2	65,69	GPIIIa	PlA2	3690	5319	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	Increased platelet_aggregability associated with platelet GPIIIa PlA2 polymorphism : the Framingham Offspring Study .
9241754	0	GPIIIa	65,71	glycoprotein_IIIa	46,63	GPIIIa	glycoprotein IIIa	3690	3690	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The Leu33/Pro polymorphism -LRB- PlA1/PlA2 -RRB- of the glycoprotein_IIIa -LRB- GPIIIa -RRB- receptor is not related to myocardial_infarction in the ECTIM Study .
3198118	0	GPIIb	35,40	GP2B	29,33	GPIIb	GP2B	3674	3674	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of human platelet GP2B -LRB- GPIIb -RRB- gene to chromosome 17 , region q21.1-q21 .3 .
20652946	0	GPIIb	18,23	IL-13	0,5	GPIIb	IL-13	3674	3596	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	IL-13 upregulates GPIIb expression in megakaryocytic cell lines via STAT6 .
12802054	0	GPI_transamidase	54,70	PIG-U	6,11	GPI transamidase	PIG-U	606750(Tax:9823)	100154657(Tax:9823)	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	Human PIG-U and yeast Cdc91p are the fifth subunit of GPI_transamidase that attaches GPI-anchors to proteins .
12719784	0	GPIbalpha	20,29	Thrombin	0,8	GPIbalpha	Thrombin	2811	2147	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Thrombin binding to GPIbalpha induces platelet_aggregation and fibrin clot retraction supported by resting alphaIIbbeta3 interaction with polymerized fibrin .
14961148	0	GPIbalpha	20,29	Thrombin	0,8	GPIbalpha	Thrombin	2811	2147	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Thrombin binding to GPIbalpha induces integrin alphaIIbbeta3 dependent platelet_adhesion to fibrin in ex vivo flowing whole blood .
11072085	0	GPLD1	85,90	glycosylphosphatidylinositol_phospholipase_D1	38,83	GPLD1	glycosylphosphatidylinositol phospholipase D1	2822	2822	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and expression of the human glycosylphosphatidylinositol_phospholipase_D1 -LRB- GPLD1 -RRB- gene .
25889792	0	GPNMB	57,62	MITF	25,29	GPNMB	MITF	10457	4286	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells .
25889792	0	GPNMB	57,62	MITF	25,29	GPNMB	MITF	10457	4286	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells .
18313864	0	GPNMB	92,97	Microphthalmia_transcription_factor	0,35	GPNMB	Microphthalmia transcription factor	93695(Tax:10090)	17342(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Microphthalmia_transcription_factor regulates the expression of the novel osteoclast factor GPNMB .
25663982	0	GPNMB	75,80	glycoprotein_non-metastatic_melanoma_protein_B	27,73	GPNMB	glycoprotein non-metastatic melanoma protein B	10457	10457	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of glycoprotein_non-metastatic_melanoma_protein_B -LRB- GPNMB -RRB- involved in trichostatin_A-induced apoptosis in gastric_cancer .
24682924	0	GPNMB	163,168	glycoprotein_nonmetastatic_melanoma_B	124,161	GPNMB	glycoprotein nonmetastatic melanoma B	10457	10457	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Induction of matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in the microglia by lipopolysaccharide -LRB- LPS -RRB- via upregulation of glycoprotein_nonmetastatic_melanoma_B -LRB- GPNMB -RRB- expression .
25772243	0	GPNMB	0,5	neuropilin-1	22,34	GPNMB	neuropilin-1	10457	8829	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|END_ENTITY	GPNMB cooperates with neuropilin-1 to promote mammary_tumor growth and engages integrin a5b1 for efficient breast_cancer metastasis .
10623592	0	GPR1	0,4	FLO11	42,47	GPR1	FLO11	851527(Tax:4932)	854836(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	GPR1 regulates filamentous growth through FLO11 in yeast Saccharomyces_cerevisiae .
8666380	0	GPR10	60,65	interleukin_8	108,121	GPR10	interleukin 8	2834	3576	Gene	Gene	related|nsubj|START_ENTITY related|nmod|END_ENTITY	Cloning and chromosomal mapping of three novel genes , GPR9 , GPR10 , and GPR14 , encoding receptors related to interleukin_8 , neuropeptide Y , and somatostatin receptors .
14742914	0	GPR10	42,47	prolactin-releasing_peptide	4,31	GPR10	prolactin-releasing peptide	226278(Tax:10090)	51052	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The prolactin-releasing_peptide receptor -LRB- GPR10 -RRB- regulates body weight homeostasis in mice .
18824219	0	GPR103	80,86	26RFa	48,53	GPR103	26RFa	310327(Tax:10116)	379044(Tax:10116)	Gene	Gene	agonist|nmod|START_ENTITY END_ENTITY|appos|agonist	Analgesic effects of intrathecally administered 26RFa , an intrinsic agonist for GPR103 , on formalin test and carrageenan test in rats .
22743741	0	GPR109A	16,23	HCA	8,11	GPR109A	HCA	338442	266790	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of HCA -LRB- GPR109A -RRB- in nicotinic_acid and fumaric_acid_ester-induced effects on the skin .
26144594	0	GPR119	27,33	GLP-1	46,51	GPR119	GLP-1	236781(Tax:10090)	14526(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells .
26230883	0	GPR120	43,49	FFAR4	51,56	GPR120	FFAR4	338557	338557	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Biological characteristics and agonists of GPR120 -LRB- FFAR4 -RRB- receptor : the present status of research .
24742677	0	GPR120	35,41	GPR120	76,82	GPR120	GPR120	107221(Tax:10090)	107221(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Alteration of the glucagon axis in GPR120 -LRB- FFAR4 -RRB- knockout mice : a role for GPR120 in glucagon secretion .
24742677	0	GPR120	76,82	GPR120	35,41	GPR120	GPR120	107221(Tax:10090)	107221(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Alteration of the glucagon axis in GPR120 -LRB- FFAR4 -RRB- knockout mice : a role for GPR120 in glucagon secretion .
24673159	0	GPR120	90,96	phospholipase_A	67,82	GPR120	phospholipase A	338557	57110	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	The fish oil ingredient , docosahexaenoic_acid , activates cytosolic phospholipase_A via GPR120 receptor to produce prostaglandin_E and plays an anti-inflammatory role in macrophages .
10548501	0	GPR14	84,89	Urotensin_II	0,12	GPR14	Urotensin II	57305(Tax:10116)	29180(Tax:10116)	Gene	Gene	SENR|appos|START_ENTITY receptor|appos|SENR ligand|nmod|receptor ligand|nsubj|END_ENTITY	Urotensin_II is the endogenous ligand of a G-protein-coupled orphan receptor , SENR -LRB- GPR14 -RRB- .
10581185	0	GPR14	98,103	urotensin_II	18,30	GPR14	urotensin II	2837	10911	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|Identification Identification|nmod|END_ENTITY	Identification of urotensin_II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14 .
12495432	0	GPR14	36,41	urotensin_II	23,35	GPR14	urotensin II	57305(Tax:10116)	29180(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY receptor|dep|Photolabelling Photolabelling|dobj|END_ENTITY	Photolabelling the rat urotensin_II / GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain .
15273242	0	GPR14	25,30	urotensin_II	66,78	GPR14	urotensin II	57305(Tax:10116)	29180(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Cellular distribution of GPR14 and the positive inotropic role of urotensin_II in the myocardium in adult rat .
15306183	0	GPR14	62,67	urotensin_II	24,36	GPR14	urotensin II	2837	10911	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Increased expression of urotensin_II and its cognate receptor GPR14 in atherosclerotic_lesions of the human aorta .
25792749	0	GPR158	16,22	Regulator_of_G_Protein_Signaling_7	53,87	GPR158	Regulator of G Protein Signaling 7	241263(Tax:10090)	24012(Tax:10090)	Gene	Gene	Modulator|nsubj|START_ENTITY Modulator|nmod|END_ENTITY	Orphan Receptor GPR158 is an Allosteric Modulator of Regulator_of_G_Protein_Signaling_7 -LRB- RGS7 -RRB- Catalytic Activity with Essential Role in Dictating its Expression and Localization in the Brain .
25792749	0	GPR158	16,22	Regulator_of_G_Protein_Signaling_7	53,87	GPR158	Regulator of G Protein Signaling 7	241263(Tax:10090)	24012(Tax:10090)	Gene	Gene	Modulator|nsubj|START_ENTITY Modulator|nmod|END_ENTITY	Orphan Receptor GPR158 is an Allosteric Modulator of Regulator_of_G_Protein_Signaling_7 -LRB- RGS7 -RRB- Catalytic Activity with Essential Role in Dictating its Expression and Localization in the Brain .
21956849	0	GPR17	4,9	NG2	22,25	GPR17	NG2	2840	1464	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	The GPR17 receptor in NG2 expressing cells : focus on in vivo cell maturation and participation in acute trauma and chronic damage .
17284443	0	GPR3	49,53	GPR6	55,59	GPR3	GPR6	266769(Tax:10116)	83683(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Neural expression of G protein-coupled receptors GPR3 , GPR6 , and GPR12 up-regulates cyclic_AMP levels and promotes neurite outgrowth .
19153601	0	GPR30	11,16	CTGF	95,99	GPR30	CTGF	2852	1490	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Estrogenic GPR30 signalling induces proliferation and migration of breast_cancer cells through CTGF .
26371374	0	GPR30	107,112	ERK1/2	85,91	GPR30	ERK1/2	2852	5595;5594	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	The sequence P295-T311 of the hinge region of the estrogen_receptor_a is involved in ERK1/2 activation via GPR30 in leiomyoma cells .
26585160	0	GPR30	43,48	G-Protein_Coupled_Receptor_30	12,41	GPR30	G-Protein Coupled Receptor 30	2852	2852	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of G-Protein_Coupled_Receptor_30 -LRB- GPR30 -RRB- on Endothelial Inflammation .
22645130	0	GPR30	0,5	GLT-1	38,43	GPR30	GLT-1	171104(Tax:10116)	29482(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes .
26998610	0	GPR30	56,61	GPER1	49,54	GPR30	GPER1	76854(Tax:10090)	76854(Tax:10090)	Gene	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Characterisation of Signalling by the Endogenous GPER1 -LRB- GPR30 -RRB- Receptor in an Embryonic Mouse Hippocampal Cell Line -LRB- mHippoE-18 -RRB- .
17379646	0	GPR30	73,78	G_protein-coupled_receptor_30	42,71	GPR30	G protein-coupled receptor 30	2852	2852	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of the novel estrogen receptor G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- at the plasma membrane .
25200186	0	GPR30	0,5	STAT3	42,47	GPR30	STAT3	76854(Tax:10090)	20848(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus .
21110987	0	GPR35	31,36	G-protein_coupled_receptor_35	0,29	GPR35	G-protein coupled receptor 35	64095(Tax:10090)	64095(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	G-protein_coupled_receptor_35 -LRB- GPR35 -RRB- activation and inflammatory_pain : Studies on the antinociceptive effects of kynurenic_acid and zaprinast .
27036049	0	GPR37	62,67	REG4	0,4	GPR37	REG4	2861	83998	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	REG4 promotes peritoneal metastasis of gastric_cancer through GPR37 .
17519329	0	GPR37	0,5	dopamine_transporter	26,46	GPR37	dopamine transporter	14763(Tax:10090)	13162(Tax:10090)	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	GPR37 associates with the dopamine_transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs .
21470317	0	GPR39	0,5	ghrelin	25,32	GPR39	ghrelin	71111(Tax:10090)	58991(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|family family|compound|END_ENTITY	GPR39 , a receptor of the ghrelin receptor family , plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity .
26381015	0	GPR40	48,53	FFAR1	41,46	GPR40	FFAR1	266607(Tax:10116)	266607(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Vascular , but not luminal , activation of FFAR1 -LRB- GPR40 -RRB- stimulates GLP-1 secretion from isolated perfused rat small intestine .
19758793	0	GPR40	31,36	G-protein-coupled_receptor_40	0,29	GPR40	G-protein-coupled receptor 40	2864	2864	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	G-protein-coupled_receptor_40 -LRB- GPR40 -RRB- expression and its regulation in human pancreatic islets : the role of type 2 diabetes and fatty_acids .
12629551	0	GPR40	79,84	insulin	26,33	GPR40	insulin	2864	3630	Gene	Gene	regulate|nmod|START_ENTITY regulate|dobj|secretion secretion|compound|END_ENTITY	Free fatty_acids regulate insulin secretion from pancreatic beta cells through GPR40 .
18583466	0	GPR40	33,38	insulin	80,87	GPR40	insulin	2864	3630	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization .
26683635	0	GPR43	43,48	GLP-1	57,62	GPR43	GLP-1	2867	2641	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Selective novel inverse agonists for human GPR43 augment GLP-1 secretion .
25633224	0	GPR43	36,41	XBP1	76,80	GPR43	XBP1	2867	7494	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The short-chain fatty_acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes .
23912594	0	GPR49	60,65	Leucine-rich_repeat-containing_G-protein_coupled_receptor_5	0,59	GPR49	Leucine-rich repeat-containing G-protein coupled receptor 5	8549	8549	Gene	Gene	activates|nsubj|START_ENTITY END_ENTITY|parataxis|activates	Leucine-rich_repeat-containing_G-protein_coupled_receptor_5 / GPR49 activates G12/13-Rho GTPase pathway .
19699797	0	GPR50	0,5	NOGO-A	30,36	GPR50	NOGO-A	9248	57142	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth .
21858214	0	GPR50	0,5	TIP60	21,26	GPR50	TIP60	9248	10524	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GPR50 interacts with TIP60 to modulate glucocorticoid_receptor signalling .
21738726	0	GPR54	0,5	EGFR	30,34	GPR54	EGFR	84634	1956	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	GPR54 -LRB- KISS1R -RRB- transactivates EGFR to promote breast_cancer cell invasiveness .
20886089	0	GPR54	0,5	ERK1/2	16,22	GPR54	ERK1/2	114229(Tax:10090)	26417;26413	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Ga -LRB- q/11 -RRB- and b-arrestin-dependent manner .
19846537	0	GPR54	14,19	GRK2	33,37	GPR54	GRK2	84634	156	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Regulation of GPR54 signaling by GRK2 and -LCB- beta -RCB- - arrestin .
18424411	0	GPR54	8,13	KISS-1	1,7	GPR54	KISS-1	84634	3814	Gene	Gene	genes|nummod|START_ENTITY genes|dep|END_ENTITY	-LSB- KISS-1 / GPR54 genes and their role in reproduction -RSB- .
23716269	0	GPR54	32,37	KISS1	14,19	GPR54	KISS1	84634	3814	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of KISS1 and KISS1R -LRB- GPR54 -RRB- may be used as favorable prognostic markers for patients with non-small_cell_lung_cancer .
17289848	0	GPR54	39,44	metastin	14,22	GPR54	metastin	78976(Tax:10116)	289023(Tax:10116)	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of metastin -LRB- kisspeptin-54 -RRB- - GPR54 signaling in the arcuate_nucleus-median eminence region during lactation in rats .
21724588	0	GPR56	0,5	VEGF	16,20	GPR56	VEGF	9289	7422	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	GPR56 Regulates VEGF production and angiogenesis during melanoma progression .
16757564	0	GPR56	0,5	tissue_transglutaminase	53,76	GPR56	tissue transglutaminase	9289	7052	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	GPR56 , an atypical G protein-coupled receptor , binds tissue_transglutaminase , TG2 , and inhibits melanoma_tumor growth and metastasis .
16757564	0	GPR56	0,5	tissue_transglutaminase	53,76	GPR56	tissue transglutaminase	9289	7052	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	GPR56 , an atypical G protein-coupled receptor , binds tissue_transglutaminase , TG2 , and inhibits melanoma_tumor growth and metastasis .
17284443	0	GPR6	55,59	GPR3	49,53	GPR6	GPR3	83683(Tax:10116)	266769(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Neural expression of G protein-coupled receptors GPR3 , GPR6 , and GPR12 up-regulates cyclic_AMP levels and promotes neurite outgrowth .
14592418	0	GPR6	85,89	Sphingosine-1-phosphate	0,23	GPR6	Sphingosine-1-phosphate	140741(Tax:10090)	13609(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2 + release by activating the sphingosine-kinase pathway .
25129106	0	GPR68	110,115	interleukin-6	124,137	GPR68	interleukin-6	314386(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Proton receptor GPR68 expression in dendritic-cell-like S100b-positive cells of rat anterior pituitary gland : GPR68 induces interleukin-6 gene expression in extracellular acidification .
25129106	0	GPR68	16,21	interleukin-6	124,137	GPR68	interleukin-6	314386(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY anterior|nsubj|expression anterior|parataxis|induces induces|dobj|expression expression|amod|END_ENTITY	Proton receptor GPR68 expression in dendritic-cell-like S100b-positive cells of rat anterior pituitary gland : GPR68 induces interleukin-6 gene expression in extracellular acidification .
22834040	0	GPR7	85,89	G-Protein_Coupled_Receptor_7	55,83	GPR7	G-Protein Coupled Receptor 7	2831	2831	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Optimization and Characterization of an Antagonist for G-Protein_Coupled_Receptor_7 -LRB- GPR7 -RRB- Heterotrimeric G-protein coupled receptors -LRB- GPCRs -RRB- , the largest family of membrane-bound receptors , are major targets for therapeutic applications due to their broad tissue distribution , structural diversity , varied modes of action , and disease-associated mutations .
23762933	0	GPR7	91,95	G-protein_Coupled_Receptor_7	61,89	GPR7	G-protein Coupled Receptor 7	2831	2831	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Optimization and Characterization of a Second Antagonist for G-protein_Coupled_Receptor_7 -LRB- GPR7 -RRB- Heterotrimeric G-protein coupled receptors -LRB- GPCRs -RRB- , the largest family of membrane-bound receptors , are major targets for therapeutic applications due to their broad tissue distribution , structural diversity , varied modes of action , and disease-associated mutations .
12130646	0	GPR7	97,101	neuropeptide_W	18,32	GPR7	neuropeptide W	2831	283869	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|Identification Identification|nmod|END_ENTITY	Identification of neuropeptide_W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8 .
11466257	0	GPR75	49,54	G_protein_coupled_receptor-75	18,47	GPR75	G protein coupled receptor-75	10936	10936	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the G_protein_coupled_receptor-75 -LRB- GPR75 -RRB- in age_related_macular_degeneration .
16389273	0	GPR78	81,86	G_protein-coupled_receptor_78	50,79	GPR78	G protein-coupled receptor 78	27201	27201	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association analysis of the chromosome 4p-located G_protein-coupled_receptor_78 -LRB- GPR78 -RRB- gene in bipolar_affective_disorder and schizophrenia .
23335960	0	GPR83	31,36	G-protein_coupled_receptor_83	0,29	GPR83	G-protein coupled receptor 83	14608(Tax:10090)	14608(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	G-protein_coupled_receptor_83 -LRB- GPR83 -RRB- signaling determined by constitutive and zinc -LRB- II -RRB- - induced activity .
15993493	0	GPR84	32,37	IL-4	48,52	GPR84	IL-4	80910(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	The G-protein coupled receptor , GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking .
27046124	0	GPR91	60,65	BMP6	70,74	GPR91	BMP6	84112(Tax:10090)	12161(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile_Hemochromatosis .
25572244	0	GPR98	31,36	USH2C	24,29	GPR98	USH2C	84059	84059	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel mutation of the USH2C -LRB- GPR98 -RRB- gene in an Iranian family with Usher_syndrome_type_II .
25311788	0	GPRC5A	55,61	EGFR	0,4	GPRC5A	EGFR	232431(Tax:10090)	13649(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	EGFR phosphorylates and inhibits lung_tumor suppressor GPRC5A in lung_cancer .
25744720	0	GPRC5A	22,28	EGFR	35,39	GPRC5A	EGFR	232431(Tax:10090)	13649(Tax:10090)	Gene	Gene	Binds|compound|START_ENTITY END_ENTITY|nsubj|Binds	Lung_Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling .
25744720	0	GPRC5A	22,28	EGFR	35,39	GPRC5A	EGFR	232431(Tax:10090)	13649(Tax:10090)	Gene	Gene	Binds|compound|START_ENTITY END_ENTITY|nsubj|Binds	Lung_Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling .
26602597	0	GPRC6A	0,6	Nlrp3	29,34	GPRC6A	Nlrp3	210198(Tax:10090)	216799(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses .
25842189	0	GPSM3	35,40	RGS5	14,18	GPSM3	RGS5	406163(Tax:10116)	54294(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of RGS5 GAP activity by GPSM3 .
7389640	0	GPT	66,69	glutamic-pyruvic_transaminase	35,64	GPT	glutamic-pyruvic transaminase	2875	2875	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Population studies of the enzyme , glutamic-pyruvic_transaminase -LRB- GPT -RRB- -RSB- .
12842985	0	GPVI	37,41	Btk	60,63	GPVI	Btk	51206	695	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Tec regulates platelet activation by GPVI in the absence of Btk .
19350111	0	GPVI	49,53	EMMPRIN	0,7	GPVI	EMMPRIN	51206	682	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction .
18826392	0	GPVI	75,79	Gads	36,40	GPVI	Gads	243816(Tax:10090)	17444(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 .
10567557	0	GPVI	119,123	LAT	0,3	GPVI	LAT	243816(Tax:10090)	16797(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	LAT is required for tyrosine phosphorylation of phospholipase_cgamma2 and platelet activation by the collagen receptor GPVI .
12730118	0	GPVI	7,11	PLCgamma2	51,60	GPVI	PLCgamma2	243816(Tax:10090)	234779(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Murine GPVI stimulates weak integrin activation in PLCgamma2 - / - platelets : involvement of PLCgamma1 and PI3-kinase .
12842985	0	GPVI	37,41	Tec	0,3	GPVI	Tec	51206	7006	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Tec regulates platelet activation by GPVI in the absence of Btk .
18795891	0	GPVI	83,87	Tspan9	18,24	GPVI	Tspan9	51206	10867	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains .
24325877	0	GPVI	60,64	glycoprotein_VI	43,58	GPVI	glycoprotein VI	51206	51206	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated plasma levels of soluble platelet glycoprotein_VI -LRB- GPVI -RRB- in patients with thrombotic_microangiopathy .
20301895	0	GPX1	101,105	CAT	89,92	GPX1	CAT	2876	847	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
24711484	0	GPX1	53,57	CAT	48,51	GPX1	CAT	2876	847	Gene	Gene	GPX4|appos|START_ENTITY GPX4|appos|END_ENTITY	Plasma antioxidants , genetic variation in SOD2 , CAT , GPX1 , GPX4 , and prostate_cancer survival .
25033027	0	GPX1	43,47	CAT	73,76	GPX1	CAT	2876	847	Gene	Gene	Pro198Leu|nummod|START_ENTITY glutathione_peroxidase_1|appos|Pro198Leu glutathione_peroxidase_1|appos|C-262T C-262T|compound|END_ENTITY	Polymorphisms of glutathione_peroxidase_1 -LRB- GPX1 Pro198Leu -RRB- and catalase -LRB- CAT C-262T -RRB- in women with spontaneous_abortion .
25436036	0	GPX1	5,9	CAT	0,3	GPX1	CAT	2876	847	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
25436036	0	GPX1	5,9	GSTM1	18,23	GPX1	GSTM1	2876	2944	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
26773925	0	GPX1	31,35	Glutathione_peroxidase-1	0,24	GPX1	Glutathione peroxidase-1	2876	2876	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glutathione_peroxidase-1 gene -LRB- GPX1 -RRB- variants , oxidative stress and risk_of_kidney_complications in people with type 1 diabetes .
25436036	0	GPX1	5,9	MnSOD	11,16	GPX1	MnSOD	2876	6648	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
7829093	0	GPX1	100,104	cellular_glutathione_peroxidase	67,98	GPX1	cellular glutathione peroxidase	2876	2876	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An in-frame trinucleotide repeat in the coding region of the human cellular_glutathione_peroxidase -LRB- GPX1 -RRB- gene : in vivo polymorphism and in vitro instability .
15318035	0	GPX1	81,85	glutathione_peroxidase	57,79	GPX1	glutathione peroxidase	2876	2876	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between the Pro197Leu polymorphism in the glutathione_peroxidase -LRB- GPX1 -RRB- gene and schizophrenia .
16413612	0	GPX1	60,64	glutathione_peroxidase	36,58	GPX1	glutathione peroxidase	2876	2876	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Genetic association analysis of the glutathione_peroxidase -LRB- GPX1 -RRB- gene polymorphism -LRB- Pro197Leu -RRB- with tardive_dyskinesia .
20877264	0	GPX1	73,77	glutathione_peroxidase	49,71	GPX1	glutathione peroxidase	2876	2876	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association of C599T polymorphism in the glutathione_peroxidase -LRB- GPX1 -RRB- gene with delayed graft function , acute kidney graft rejection and chronic allograft nephropathy .
8287691	0	GPX2	39,43	GPX3	45,49	GPX2	GPX3	2877	2878	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The human glutathione peroxidase genes GPX2 , GPX3 , and GPX4 map to chromosomes 14 , 5 , and 19 , respectively .
15135069	0	GPX2	74,78	Yap1	114,118	GPX2	Yap1	852546(Tax:4932)	855005(Tax:4932)	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	Regulation of the yeast phospholipid hydroperoxide_glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7 .
10806356	0	GPX2	78,82	gastrointestinal_glutathione_peroxidase	37,76	GPX2	gastrointestinal glutathione peroxidase	2877	2877	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Structural organization of the human gastrointestinal_glutathione_peroxidase -LRB- GPX2 -RRB- promoter and 3 ' - nontranscribed region : transcriptional response to exogenous redox agents .
23934683	0	GPX2	104,108	miR-185	72,79	GPX2	miR-185	2877	406961	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Selenium alters miRNA profile in an intestinal cell line : evidence that miR-185 regulates expression of GPX2 and SEPSH2 .
16446369	0	GPX2	0,4	p63	25,28	GPX2	p63	2877	8626	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	GPX2 , a direct target of p63 , inhibits oxidative stress-induced apoptosis in a p53-dependent manner .
8287691	0	GPX3	45,49	GPX2	39,43	GPX3	GPX2	2878	2877	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The human glutathione peroxidase genes GPX2 , GPX3 , and GPX4 map to chromosomes 14 , 5 , and 19 , respectively .
10542376	0	GPX5	77,81	glutathione_peroxidase_5	43,67	GPX5	glutathione peroxidase 5	14780(Tax:10090)	14780(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Selenium-independent epididymis-restricted glutathione_peroxidase_5 protein -LRB- GPX5 -RRB- can back up failing Se-dependent GPXs in mice subjected to selenium deficiency .
13678940	0	GP_IIIa	74,81	PlA1	68,72	GP IIIa	PlA1	3690	25833	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Resistance in vitro to low-dose aspirin is associated with platelet PlA1 -LRB- GP_IIIa -RRB- polymorphism but not with C807T -LRB- GP_Ia / IIa -RRB- and C-5T Kozak -LRB- GP_Ibalpha -RRB- polymorphisms .
7684270	0	GP_IV	40,45	Nak	54,57	GP IV	Nak	51206	29110	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Presence of the entire coding region of GP_IV mRNA in Nak -LRB- a -RRB- - negative platelets .
18237028	0	GPx-1	57,62	cellular_glutathione_peroxidase	24,55	GPx-1	cellular glutathione peroxidase	2876	2876	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Homocysteine effects on cellular_glutathione_peroxidase -LRB- GPx-1 -RRB- activity under in vitro conditions .
15331559	0	GPx-1	53,58	glutathione_peroxidase-1	27,51	GPx-1	glutathione peroxidase-1	2876	2876	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional variants in the glutathione_peroxidase-1 -LRB- GPx-1 -RRB- gene are associated with increased intima-media_thickness of carotid arteries and risk of macrovascular_diseases in japanese type 2 diabetic patients .
17122425	0	GPx-3	61,66	plasma_glutathione_peroxidase	30,59	GPx-3	plasma glutathione peroxidase	2878	2878	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter polymorphisms in the plasma_glutathione_peroxidase -LRB- GPx-3 -RRB- gene : a novel risk factor for arterial_ischemic_stroke among young adults and children .
18096833	0	GPx-3	69,74	plasma_glutathione_peroxidase	38,67	GPx-3	plasma glutathione peroxidase	2878	2878	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of promoter polymorphisms in the plasma_glutathione_peroxidase -LRB- GPx-3 -RRB- gene as a risk factor for cerebral_venous_thrombosis .
25283363	0	GPx1	83,87	Glutathione_peroxidase_1	57,81	GPx1	Glutathione peroxidase 1	2876	2876	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of Superoxide dismutases -LRB- SOD1 and SOD2 -RRB- and Glutathione_peroxidase_1 -LRB- GPx1 -RRB- gene polymorphisms with Type_2_diabetes_mellitus .
18267129	0	GPx1	125,129	glutathione_peroxidase	101,123	GPx1	glutathione peroxidase	24404(Tax:10116)	24404(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Sensitization by docosahexaenoic_acid -LRB- DHA -RRB- of breast_cancer cells to anthracyclines through loss of glutathione_peroxidase -LRB- GPx1 -RRB- response .
25606455	0	GPx1	53,57	glutathione_peroxidase1	28,51	GPx1	glutathione peroxidase1	2876	2876	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Lack of association between glutathione_peroxidase1 -LRB- GPx1 -RRB- activity , Pro198Leu polymorphism and stenosis of coronary arteries : A population-based prediction .
21993316	0	GPx1	66,70	glutathione_peroxidase_1	40,64	GPx1	glutathione peroxidase 1	2876	2876	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between genetic variants in glutathione_peroxidase_1 -LRB- GPx1 -RRB- gene , GPx activity and the risk of prostate_cancer .
17937616	0	GPx2	44,48	glutathione_peroxidase_2	18,42	GPx2	glutathione peroxidase 2	2877	2877	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Activation of the glutathione_peroxidase_2 -LRB- GPx2 -RRB- promoter by beta-catenin .
25333265	0	GPx3	73,77	glutathione_peroxidase_3	47,71	GPx3	glutathione peroxidase 3	2878	2878	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance and therapeutic value of glutathione_peroxidase_3 -LRB- GPx3 -RRB- in hepatocellular_carcinoma .
14560994	0	GR	25,27	Glucocorticoid_receptor	0,23	GR	Glucocorticoid receptor	2908	2908	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucocorticoid_receptor -LRB- GR -RRB- immunohistochemical expression is correlated with cell cycle-related molecules in human colon_cancer .
23814048	0	GR	40,42	estrogen_receptor	49,66	GR	estrogen receptor	2908	2099	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
23814048	0	GR	40,42	glucocorticoid_receptor	15,38	GR	glucocorticoid receptor	2908	2908	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
25755906	0	GR	37,39	glucocorticoid_receptor	12,35	GR	glucocorticoid receptor	2908	2908	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of glucocorticoid_receptor -LRB- GR -RRB- polymorphisms in human erythropoiesis .
25762479	0	GR	65,67	glucocorticoid_receptor	40,63	GR	glucocorticoid receptor	2908	2908	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical and biological significance of glucocorticoid_receptor -LRB- GR -RRB- expression in breast_cancer .
16469493	0	GR-LACS	103,110	gonadotropin-regulated_long_chain_acyl-CoA_synthetase	48,101	GR-LACS	gonadotropin-regulated long chain acyl-CoA synthetase	171410(Tax:10116)	171410(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Tissue-cell - and species-specific expression of gonadotropin-regulated_long_chain_acyl-CoA_synthetase -LRB- GR-LACS -RRB- in gonads , adrenal and brain .
20704716	0	GRAF	60,64	GTPase_regulator_associated_with_the_focal_adhesion_kinase	0,58	GRAF	GTPase regulator associated with the focal adhesion kinase	23092	23092	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	GTPase_regulator_associated_with_the_focal_adhesion_kinase -LRB- GRAF -RRB- transcript was down-regulated in patients with myeloid_malignancies .
15174222	0	GRAP	49,53	Grb-2-related_adaptor_protein	13,42	GRAP	Grb-2-related adaptor protein	71520(Tax:10090)	71520(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of Grb-2-related_adaptor_protein gene -LRB- GRAP -RRB- and peptide molecule in salivary glands of MRL/lpr mice and patients with Sj __ gren 's _ syndrome .
16473605	0	GRASP55	44,51	Rab2	57,61	GRASP55	Rab2	26003	5862	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Purification and functional interactions of GRASP55 with Rab2 .
7568038	0	GRB-2	111,116	CD28	27,31	GRB-2	CD28	2885	940	Gene	Gene	factor|dep|START_ENTITY factor|compound|END_ENTITY	p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase , growth factor receptor-bound protein GRB-2 , and T_cell-specific_protein-tyrosine_kinase ITK : implications for T-cell costimulation .
7737275	0	GRB-2	33,38	SOS	39,42	GRB-2	SOS	2885	34790(Tax:7227)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	T cell antigen CD28 binds to the GRB-2 / SOS complex , regulators of p21ras .
9747873	0	GRB10	35,40	BCR-ABL	56,63	GRB10	BCR-ABL	14783(Tax:10090)	25	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The SH2-containing adapter protein GRB10 interacts with BCR-ABL .
17376403	0	GRB10	0,5	LRP6	15,19	GRB10	LRP6	2887	4040	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	GRB10 binds to LRP6 , the Wnt co-receptor and inhibits canonical Wnt signaling pathway .
8647858	0	GRB14	32,37	GRB7	61,65	GRB14	GRB7	2888	2886	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Cloning and characterization of GRB14 , a novel member of the GRB7 gene family .
17314098	0	GRB2	68,72	Amyloid_precursor_protein	0,25	GRB2	Amyloid precursor protein	2885	351	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Amyloid_precursor_protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK_1 ,2 signaling .
8491186	0	GRB2	38,42	IRS1	82,86	GRB2	IRS1	2885	3667	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc : implications for insulin control of ras signalling .
11997181	0	GRB2	86,90	SHC	65,68	GRB2	SHC	2885	6464	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2 .
8493579	0	GRB2	71,75	Sos1	6,10	GRB2	Sos1	2885	6654	Gene	Gene	binds|nmod|START_ENTITY factor|acl:relcl|binds END_ENTITY|dep|factor	Human Sos1 : a guanine_nucleotide exchange factor for Ras that binds to GRB2 .
14687710	0	GRB2	14,18	TNF-alpha	44,53	GRB2	TNF-alpha	2885	7124	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of GRB2 and FLICE2 expression by TNF-alpha in rheumatoid synovium .
8702859	0	GRB2	120,124	protein-tyrosine_phosphatase_1D	44,75	GRB2	protein-tyrosine phosphatase 1D	2885	5781	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Epidermal_growth_factor induces coupling of protein-tyrosine_phosphatase_1D to GRB2 via the COOH-terminal SH3 domain of GRB2 .
8647858	0	GRB7	61,65	GRB14	32,37	GRB7	GRB14	2886	2888	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Cloning and characterization of GRB14 , a novel member of the GRB7 gene family .
17666587	0	GREB1	25,30	estrogen_receptor	34,51	GREB1	estrogen receptor	9687	2099	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Long-range activation of GREB1 by estrogen_receptor via three distal consensus estrogen-responsive elements in breast_cancer cells .
17463000	0	GREB1	14,19	estrogen_receptor_alpha	37,60	GREB1	estrogen receptor alpha	9687	2099	Gene	Gene	Regulation|nmod|START_ENTITY transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of GREB1 transcription by estrogen_receptor_alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences .
21655089	0	GREM1	62,67	BMP4	69,73	GREM1	BMP4	26585	652	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Multiple common susceptibility variants near BMP pathway loci GREM1 , BMP4 , and BMP2 explain part of the missing heritability of colorectal_cancer .
19577778	0	GREM1	25,30	gremlin_1	14,23	GREM1	gremlin 1	26585	26585	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of gremlin_1 -LRB- GREM1 -RRB- as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type_2_diabetes_mellitus .
2863915	0	GRF	101,104	GH	23,25	GRF	GH	2691	2688	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Plasma growth_hormone -LRB- GH -RRB- and somatomedin_C response to continuous growth_hormone-releasing factor -LRB- GRF -RRB- infusion in patients with GH_deficiency .
2226343	0	GRF	67,70	GH-releasing_factor	46,65	GRF	GH-releasing factor	2691	2691	Gene	Gene	Change|appos|START_ENTITY Change|nmod|END_ENTITY	Change in the growth_hormone -LRB- GH -RRB- response to GH-releasing_factor -LRB- GRF -RRB- caused by exogenous GH in short children .
3003561	0	GRF	139,142	GRF	65,68	GRF	GRF	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY using|dobj|receptors intestinal|xcomp|using intestinal|nsubj|Study Study|nmod|specificity specificity|nmod|interaction interaction|appos|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	GRF	65,68	GRF	139,142	GRF	GRF	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	interaction|appos|START_ENTITY specificity|nmod|interaction Study|nmod|specificity intestinal|nsubj|Study intestinal|xcomp|using using|dobj|receptors receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
11445245	0	GRF	42,45	VIP	84,87	GRF	VIP	2691	7432	Gene	Gene	analogue|compound|START_ENTITY side-effects|nmod|analogue due|nsubj|side-effects due|nmod|activity activity|compound|END_ENTITY	GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity .
2853835	0	GRF	88,91	VIP	46,49	GRF	CRF	29446(Tax:10116)	81648(Tax:10116)	Gene	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	Interaction of vasoactive intestinal peptide -LRB- VIP -RRB- and growth_hormone_releasing_factor -LRB- GRF -RRB- with corticotropin_releasing_factor -LRB- CRF -RRB- on corticotropin secretion in vitro .
2859987	0	GRF	48,51	VIP	108,111	GRF	VIP	29446(Tax:10116)	117064(Tax:10116)	Gene	Gene	growth_hormone-releasing_factor|appos|START_ENTITY Interaction|nmod|growth_hormone-releasing_factor analogs|nsubj|Interaction analogs|nmod|receptors receptors|appos|END_ENTITY	Interaction of growth_hormone-releasing_factor -LRB- GRF -RRB- and 14 GRF analogs with vasoactive intestinal peptide -LRB- VIP -RRB- receptors of rat pancreas .
2859987	1	GRF	172,175	VIP	191,194	GRF	VIP	29446(Tax:10116)	117064(Tax:10116)	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|dep|NH2 NH2|nmod|antagonist antagonist|compound|END_ENTITY	Discovery of -LRB- N-Ac-Tyr1 , D-Phe2 -RRB- - GRF -LRB- 1-29 -RRB- - NH2 as a VIP antagonist .
3003561	0	GRF	139,142	VIP	118,121	GRF	VIP	29446(Tax:10116)	117064(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY using|dobj|receptors intestinal|xcomp|using intestinal|dobj|receptors receptors|appos|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	GRF	139,142	VIP	158,161	GRF	VIP	29446(Tax:10116)	117064(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	GRF	139,142	VIP	235,238	GRF	VIP	29446(Tax:10116)	7432	Gene	Gene	receptors|compound|START_ENTITY using|dobj|receptors intestinal|xcomp|using intestinal|ccomp|antagonist antagonist|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	GRF	65,68	VIP	118,121	GRF	VIP	29446(Tax:10116)	117064(Tax:10116)	Gene	Gene	interaction|appos|START_ENTITY specificity|nmod|interaction Study|nmod|specificity intestinal|nsubj|Study intestinal|dobj|receptors receptors|appos|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	GRF	65,68	VIP	158,161	GRF	VIP	29446(Tax:10116)	117064(Tax:10116)	Gene	Gene	interaction|appos|START_ENTITY specificity|nmod|interaction Study|nmod|specificity intestinal|nsubj|Study intestinal|xcomp|using using|dobj|receptors receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	GRF	65,68	VIP	235,238	GRF	VIP	29446(Tax:10116)	7432	Gene	Gene	interaction|appos|START_ENTITY specificity|nmod|interaction Study|nmod|specificity intestinal|nsubj|Study intestinal|ccomp|antagonist antagonist|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3930577	0	GRF	53,56	growth-hormone-releasing_factor	20,51	GRF	growth-hormone-releasing factor	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	The distribution of growth-hormone-releasing_factor -LRB- GRF -RRB- immunoreactivity in the central nervous system of the rat : an immunohistochemical study using antisera directed against rat hypothalamic GRF .
1974524	0	GRF	48,51	growth_hormone-releasing_factor	15,46	GRF	growth hormone-releasing factor	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- The effect of growth_hormone-releasing_factor -LRB- GRF -RRB- on secretion of insulin , glucagon and somatostatin from perfused rat pancreas -RSB- .
1977581	0	GRF	67,70	growth_hormone-releasing_factor	34,65	GRF	growth hormone-releasing factor	2691	2691	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Cysteamine-induced enhancement of growth_hormone-releasing_factor -LRB- GRF -RRB- immunoreactivity in arcuate neurons : morphological evidence for putative somatostatin/GRF interactions within hypothalamus .
2537185	0	GRF	45,48	growth_hormone-releasing_factor	12,43	GRF	growth hormone-releasing factor	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Blockade of growth_hormone-releasing_factor -LRB- GRF -RRB- activity in the pituitary and hypothalamus of the conscious rat with a peptidic GRF antagonist .
3095799	0	GRF	57,60	growth_hormone-releasing_factor	24,55	GRF	growth hormone-releasing factor	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of endogenous growth_hormone-releasing_factor -LRB- GRF -RRB- on the secretion of GH during the perinatal period in the rat .
6091630	0	GRF	0,3	neurotensin	41,52	GRF	neurotensin	29446(Tax:10116)	299757(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	GRF -LRB- somatocrinin -RRB- stimulates release of neurotensin , calcitonin and cAMP by a rat C cell line .
24756066	0	GRHL2	18,23	ZEB1	91,95	GRHL2	ZEB1	79977	6935	Gene	Gene	Downregulation|nmod|START_ENTITY inhibits|nsubj|Downregulation inhibits|advcl|targeting targeting|dobj|END_ENTITY	Downregulation of GRHL2 inhibits the proliferation of colorectal_cancer cells by targeting ZEB1 .
21557239	0	GRHL2	28,33	grainyhead-like_2	4,21	GRHL2	grainyhead-like 2	79977	79977	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The grainyhead-like_2 gene -LRB- GRHL2 -RRB- single nucleotide polymorphism is not associated with age-related_hearing_impairment in Han Chinese .
17921507	0	GRHL2	28,33	grainyhead_like_2	4,21	GRHL2	grainyhead like 2	79977	79977	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The grainyhead_like_2 gene -LRB- GRHL2 -RRB- , alias TFCP2L3 , is associated with age-related_hearing_impairment .
14635115	0	GRHPR	48,53	glyoxylate_reductase	26,46	GRHPR	glyoxylate reductase	9380	9380	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Molecular analysis of the glyoxylate_reductase -LRB- GRHPR -RRB- gene and description of mutations underlying primary hyperoxaluria_type_2 .
25224260	1	GRIA1	99,104	GluA1	106,111	GRIA1	GluA1	14799(Tax:10090)	14799(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A role for impaired short-term habituation and the GRIA1 -LRB- GluA1 -RRB- AMPA receptor subunit .
20689760	0	GRIA3	19,24	CUX1	36,40	GRIA3	CUX1	2892	1523	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	Glutamate receptor GRIA3 -- target of CUX1 and mediator of tumor progression in pancreatic_cancer .
10644433	0	GRIA3	65,70	glutamate_receptor_subunit_3	30,58	GRIA3	glutamate receptor subunit 3	2892	2892	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the human glutamate_receptor_subunit_3 gene -LRB- GRIA3 -RRB- , a candidate for bipolar_disorder and nonspecific X-linked mental_retardation .
15450689	0	GRIA4	86,91	GluR4	74,79	GRIA4	GluR4	2893	2893	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene -LRB- GRIA4 -RRB- and schizophrenia in the Chinese population .
9465309	0	GRID2	43,48	glutamate_receptor_delta_2	10,36	GRID2	glutamate receptor delta 2	2895	2895	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human glutamate_receptor_delta_2 gene -LRB- GRID2 -RRB- maps to chromosome 4q22 .
17062640	0	GRIF1	0,5	Hrs	12,15	GRIF1	Hrs	66008	9146	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	GRIF1 binds Hrs and is a new regulator of endosomal trafficking .
9259378	0	GRIK1	85,90	GluR5	56,61	GRIK1	GluR5	2897	2897	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic association of juvenile_absence_epilepsy with a GluR5 kainate receptor gene -LRB- GRIK1 -RRB- polymorphism .
8034316	0	GRIK2	30,35	GluR6	6,11	GRIK2	GluR6	2898	2898	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Human GluR6 kainate receptor -LRB- GRIK2 -RRB- : molecular cloning , expression , polymorphism , and chromosomal assignment .
17626740	0	GRIM-19	17,24	STAT3	53,58	GRIM-19	STAT3	51079	6774	Gene	Gene	Correlations|nmod|START_ENTITY END_ENTITY|nsubj|Correlations	-LSB- Correlations of GRIM-19 and its target gene product STAT3 to malignancy of human colorectal_carcinoma -RSB- .
23124042	0	GRIM-19	0,7	STAT3	21,26	GRIM-19	STAT3	51079	6774	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric_cancer cells to radiation .
23271731	0	GRIM-19	74,81	STAT3	39,44	GRIM-19	STAT3	51079	6774	Gene	Gene	depends|nmod|START_ENTITY depends|nsubj|import import|nmod|END_ENTITY	The import of the transcription factor STAT3 into mitochondria depends on GRIM-19 , a component of the electron transport chain .
23386605	0	GRIM-19	91,98	STAT3	169,174	GRIM-19	STAT3	51079	6774	Gene	Gene	mortality|appos|START_ENTITY associated|nmod|mortality gene|acl|associated mutations|nmod|gene disrupt|nsubj|mutations disrupt|dobj|activity activity|amod|anti-signal_transducer_and_activator_of_transcription_3 anti-signal_transducer_and_activator_of_transcription_3|dep|END_ENTITY	Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality -LRB- GRIM-19 -RRB- disrupt its anti-signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activity and promote oncogenesis .
23618357	0	GRIM-19	19,26	STAT3	46,51	GRIM-19	STAT3	51079	6774	Gene	Gene	Down-regulation|nmod|START_ENTITY associated|nsubjpass|Down-regulation associated|nmod|overexpression overexpression|nummod|END_ENTITY	Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast_carcinomas .
12628925	0	GRIM-19	0,7	Stat3	53,58	GRIM-19	Stat3	67184(Tax:10090)	20848(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|amod|END_ENTITY	GRIM-19 , a death-regulatory gene product , suppresses Stat3 activity via functional interaction .
15753091	0	GRIM-19	0,7	nucleotide_oligomerization_domain_2	23,58	GRIM-19	nucleotide oligomerization domain 2	51079	64127	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GRIM-19 interacts with nucleotide_oligomerization_domain_2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells .
12867595	0	GRIM-19	25,32	signal_transducer_and_activator_of_transcription_3	52,102	GRIM-19	signal transducer and activator of transcription 3	51079	6774	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	The cell death regulator GRIM-19 is an inhibitor of signal_transducer_and_activator_of_transcription_3 .
17284422	0	GRIN1	30,35	BDNF	37,41	GRIN1	BDNF	2902	627	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	-LSB- An association study between GRIN1 , BDNF genes and bipolar_disorder -RSB- .
15841096	0	GRIN1	76,81	GRIN2B	106,112	GRIN1	GRIN2B	2902	2904	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	An association study of the N-methyl-D-aspartate receptor NR1 subunit gene -LRB- GRIN1 -RRB- and NR2B subunit gene -LRB- GRIN2B -RRB- in schizophrenia with universal DNA microarray .
12363394	0	GRIN1	106,111	N-methyl-D-aspartate_receptor_subunit_NR1	58,99	GRIN1	N-methyl-D-aspartate receptor subunit NR1	2902	2902	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate_receptor_subunit_NR1 gene -LRB- GRIN1 -RRB- : implications for schizophrenia .
15841096	0	GRIN2B	106,112	GRIN1	76,81	GRIN2B	GRIN1	2904	2902	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	An association study of the N-methyl-D-aspartate receptor NR1 subunit gene -LRB- GRIN1 -RRB- and NR2B subunit gene -LRB- GRIN2B -RRB- in schizophrenia with universal DNA microarray .
26690829	0	GRIN2B	63,69	GluN2B	43,49	GRIN2B	GluN2B	2904	2904	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Combined effect of genetic variants in the GluN2B coding gene -LRB- GRIN2B -RRB- on prefrontal function during working memory performance .
11317224	0	GRIN2B	34,40	NMDAR2B	25,32	GRIN2B	NMDAR2B	2904	2904	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation analysis of the NMDAR2B -LRB- GRIN2B -RRB- gene in schizophrenia .
24863970	0	GRIN2B	49,55	RAI1	37,41	GRIN2B	RAI1	2904	10743	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Three rare_diseases in one Sib pair : RAI1 , PCK1 , GRIN2B mutations associated with Smith-Magenis_Syndrome , cytosolic_PEPCK_deficiency and NMDA receptor glutamate insensitivity .
9506965	0	GRIP-1	77,83	estrogen_receptor	144,161	GRIP-1	estrogen receptor	23426	2099	Gene	Gene	activity|nmod|START_ENTITY Enhancement|nmod|activity highlights|nsubj|Enhancement highlights|advcl|determining determining|dobj|pharmacology pharmacology|compound|END_ENTITY	Enhancement of estrogen_receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation_function_2 in determining estrogen_receptor pharmacology .
9506965	0	GRIP-1	77,83	estrogen_receptor	15,32	GRIP-1	estrogen receptor	23426	2099	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Enhancement of estrogen_receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation_function_2 in determining estrogen_receptor pharmacology .
19846537	0	GRK2	33,37	GPR54	14,19	GRK2	GPR54	156	84634	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Regulation of GPR54 signaling by GRK2 and -LCB- beta -RCB- - arrestin .
10567420	0	GRK2	78,82	G_protein-coupled_receptor_kinase_2	41,76	GRK2	G protein-coupled receptor kinase 2	110355(Tax:10090)	110355(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Agonist-dependent phosphorylation of the G_protein-coupled_receptor_kinase_2 -LRB- GRK2 -RRB- by Src tyrosine kinase .
10574913	0	GRK2	60,64	G_protein-coupled_receptor_kinase_2	23,58	GRK2	G protein-coupled receptor kinase 2	156	156	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Feedback inhibition of G_protein-coupled_receptor_kinase_2 -LRB- GRK2 -RRB- activity by extracellular signal-regulated kinases .
15471870	0	GRK2	24,28	Galphaq	45,52	GRK2	Galphaq	156	2776	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Characterization of the GRK2 binding site of Galphaq .
23460259	0	GRK2	0,4	IGF-1R	26,32	GRK2	IGF-1R	156	3480	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GRK2 negatively regulates IGF-1R signaling pathway and cyclins ' expression in HepG2 cells .
16762799	0	GRK2	21,25	betaARK1	27,35	GRK2	betaARK1	156	156	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Lymphocyte levels of GRK2 -LRB- betaARK1 -RRB- mirror changes in the LVAD-supported failing human heart : lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading .
16982618	0	GRK3	43,47	ERK1/2	33,39	GRK3	ERK1/2	320129(Tax:10090)	26417;26413	Gene	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Mu opioid receptor activation of ERK1/2 is GRK3 and arrestin dependent in striatal neurons .
18165681	0	GRK3	103,107	GRK3	67,71	GRK3	GRK3	320129(Tax:10090)	320129(Tax:10090)	Gene	Gene	Functions|nmod|START_ENTITY Functions|compound|END_ENTITY	Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth : GRK3 controls cardiac alpha1-adrenergic receptor responsiveness .
18165681	0	GRK3	67,71	GRK3	103,107	GRK3	GRK3	320129(Tax:10090)	320129(Tax:10090)	Gene	Gene	Functions|compound|START_ENTITY Functions|nmod|END_ENTITY	Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth : GRK3 controls cardiac alpha1-adrenergic receptor responsiveness .
24218433	0	GRK4	8,12	AT1_receptor	43,55	GRK4	AT1 receptor	14772(Tax:10090)	11610(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of GRK4 in the regulation of arterial AT1_receptor in hypertension .
9685424	0	GRK5	51,55	G_protein-coupled_receptor_kinase_5	14,49	GRK5	G protein-coupled receptor kinase 5	2869	2869	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of G_protein-coupled_receptor_kinase_5 -LRB- GRK5 -RRB- by actin .
22078319	0	GRK5	34,38	TLR2	42,46	GRK5	TLR2	14773(Tax:10090)	24088(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Overlapping and distinct roles of GRK5 in TLR2 - , and TLR3-induced inflammatory response in vivo .
24755472	0	GRK5	34,38	moesin	54,60	GRK5	moesin	2869	4478	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate_cancer .
23359120	0	GRK6	51,55	G-protein-coupled_receptor_kinase_6	14,49	GRK6	G-protein-coupled receptor kinase 6	59076(Tax:10116)	59076(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of G-protein-coupled_receptor_kinase_6 -LRB- GRK6 -RRB- after acute spinal_cord_injury in adult rat .
25881508	0	GRK6	0,4	IkBa	20,24	GRK6	IkBa	2870	4792	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	GRK6 phosphorylates IkBa at Ser -LRB- 32 -RRB- / Ser -LRB- 36 -RRB- and enhances TNF-a-induced inflammation .
11525421	0	GRM4	66,70	mGluR4	58,64	GRM4	mGluR4	2914	14802(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation screening of the metabotropic glutamate receptor mGluR4 -LRB- GRM4 -RRB- gene in patients with schizophrenia .
18329248	0	GRM7	62,66	mGluR7	54,60	GRM7	mGluR7	2917	14807(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A polymorphism of the metabotropic glutamate receptor mGluR7 -LRB- GRM7 -RRB- gene is associated with schizophrenia .
17343208	0	GRN	23,26	granulin	8,16	GRN	granulin	733645(Tax:9823)	733645(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Porcine granulin gene -LRB- GRN -RRB- : molecular cloning , polymorphism and chromosomal localization .
18183624	0	GRN	49,52	progranulin	36,47	GRN	progranulin	2896	2896	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of novel progranulin -LRB- GRN -RRB- mutations in frontotemporal_dementia .
21154232	0	GRN	152,155	progranulin	139,150	GRN	progranulin	2896	2896	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal_lobar_degeneration -LRB- FTLD -RRB- with progranulin -LRB- GRN -RRB- mutation .
22072213	0	GRN	17,20	progranulin	4,15	GRN	progranulin	2896	2896	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	The progranulin -LRB- GRN -RRB- Cys157LysfsX97 mutation is associated with nonfluent variant of primary progressive aphasia clinical phenotype .
16941962	0	GRO-1	15,20	VEGF	47,51	GRO-1	VEGF	2919	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of GRO-1 and its relationship with VEGF in squamous_cell_carcinoma of larynx -RSB- .
25135733	0	GRO-a	34,39	IL-17	11,16	GRO-a	IL-17	2919	3605	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of IL-17 on expression of GRO-a and IL-8 in fibroblasts from nasal_polyps .
12591113	0	GRO-alpha	61,70	GCP-2	53,58	GRO-alpha	GCP-2	2919	6372	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Pharmacological modulation of interleukin-17-induced GCP-2 - , GRO-alpha - and interleukin-8 release in human bronchial epithelial cells .
20621720	0	GRO-alpha	25,34	IL-6	10,14	GRO-alpha	IL-6	2919	3569	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells .
7482442	0	GRO_alpha	17,26	MGSA	27,31	GRO alpha	MGSA	2919	2919	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Thrombin induces GRO_alpha / MGSA production in human umbilical vein endothelial cells .
7482442	0	GRO_alpha	17,26	Thrombin	0,8	GRO alpha	Thrombin	2919	2147	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Thrombin induces GRO_alpha / MGSA production in human umbilical vein endothelial cells .
3390695	0	GRP	27,30	Gastrin-releasing_peptide	0,25	GRP	Gastrin-releasing peptide	171101(Tax:10116)	171101(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Gastrin-releasing_peptide -LRB- GRP -RRB- immunoreactivity in the rat retina : a radioimmunoassay , immunohistochemical and chromatographic study .
2468544	0	GRP	50,53	bombesin	10,18	GRP	bombesin	2922	2922	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of bombesin and its mammalian counterpart , GRP , on exocrine pancreas in the rat .
10587610	0	GRP	41,44	gastrin-releasing_peptide	14,39	GRP	gastrin-releasing peptide	225642(Tax:10090)	225642(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Modulation of gastrin-releasing_peptide -LRB- GRP -RRB- receptors in insulin secreting cells .
14692689	0	GRP	41,44	gastrin-releasing_peptide	14,39	GRP	gastrin-releasing peptide	615323(Tax:9913)	615323(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of gastrin-releasing_peptide -LRB- GRP -RRB- in the bovine uterus during the estrous cycle .
14997389	0	GRP	59,62	gastrin-releasing_peptide	32,57	GRP	gastrin-releasing peptide	615323(Tax:9913)	615323(Tax:9913)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of gastrin-releasing_peptide -LRB- GRP -RRB- in the uterine gland of cow .
15007209	0	GRP	58,61	gastrin-releasing_peptide	31,56	GRP	gastrin-releasing peptide	615323(Tax:9913)	615323(Tax:9913)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and expression of gastrin-releasing_peptide -LRB- GRP -RRB- in the bovine cervix .
16836584	0	GRP	49,52	gastrin-releasing_peptide	22,47	GRP	gastrin-releasing peptide	225642(Tax:10090)	225642(Tax:10090)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of gastrin-releasing_peptide -LRB- GRP -RRB- in the uteroplacenta of the mouse deer .
24894852	0	GRP	54,57	gastrin-releasing_peptide	27,52	GRP	gastrin-releasing peptide	2922	2922	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of gastrin-releasing_peptide -LRB- GRP -RRB- in normal and cancerous urological tissues .
3704194	0	GRP	70,73	gastrin-releasing_peptide	43,68	GRP	gastrin-releasing peptide	171101(Tax:10116)	171101(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Neuronal localization and motor effects of gastrin-releasing_peptide -LRB- GRP -RRB- in rat uterus .
8963395	0	GRP	37,40	gastrin-releasing_peptide	10,35	GRP	gastrin-releasing peptide	100728828	100728828	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of gastrin-releasing_peptide -LRB- GRP -RRB- on guinea_pig gallbladder contraction in vitro .
9430795	0	GRP	38,41	gastrin-releasing_peptide	11,36	GRP	gastrin-releasing peptide	2922	2922	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of gastrin-releasing_peptide -LRB- GRP -RRB- on the mechanical activity of the human ileocaecal region in vitro .
1577168	0	GRP	49,52	gastrin_releasing_peptide	22,47	GRP	gastrin releasing peptide	171101(Tax:10116)	171101(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Functional control of gastrin_releasing_peptide -LRB- GRP -RRB- mRNA in rat stomach .
6482663	0	GRP	46,49	gastrin_releasing_peptide	19,44	GRP	gastrin releasing peptide	2922	2922	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of porcine gastrin_releasing_peptide -LRB- GRP -RRB- on canine antral motility and gastrin release in vivo .
7985517	0	GRP	43,46	gonadotropin-releasing_peptide	11,41	GRP	gonadotropin-releasing peptide	225642(Tax:10090)	225642(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of gonadotropin-releasing_peptide -LRB- GRP -RRB- on LH secretion of mouse pituitary in vitro -RSB- .
3379103	0	GRP	119,122	pro-GRP	99,106	GRP	pro-GRP	2922	2922	Gene	Gene	synthesize|nmod|START_ENTITY synthesize|dobj|END_ENTITY	Swiss 3T3 mouse embryo fibroblasts transfected with a human prepro-GRP gene synthesize and secrete pro-GRP rather than GRP .
18757373	0	GRP-78	40,46	dentin_matrix_protein_1	71,94	GRP-78	dentin matrix protein 1	14828(Tax:10090)	13406(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|endocytosis endocytosis|nmod|END_ENTITY	Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin_matrix_protein_1 .
15872357	0	GRP-R	57,62	bombesin	23,31	GRP-R	bombesin	2925	2922	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs .
26897133	0	GRP-R	82,87	gastrin-releasing_peptide_receptor	46,80	GRP-R	gastrin-releasing peptide receptor	2925	2925	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Pre-clinical evaluation of eight DOTA coupled gastrin-releasing_peptide_receptor -LRB- GRP-R -RRB- ligands for in vivo targeting of receptor-expressing tumors .
24516643	0	GRP78	51,56	Akt1	91,95	GRP78	Akt1	3309	207	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
11410313	0	GRP78	16,21	BiP	11,14	GRP78	BiP	3309	3309	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Changes in BiP -LRB- GRP78 -RRB- levels upon HSV-1 infection are strain dependent .
19421146	0	GRP78	43,48	Cripto	12,18	GRP78	Cripto	3309	6998	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways .
19421146	0	GRP78	43,48	Cripto	68,74	GRP78	Cripto	3309	6998	Gene	Gene	binding|nmod|START_ENTITY Blockade|nmod|binding inhibits|nsubj|Blockade inhibits|dobj|signaling signaling|compound|END_ENTITY	Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways .
21982233	0	GRP78	106,111	Cripto	0,6	GRP78	Cripto	14828(Tax:10090)	21667(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78 .
25218495	0	GRP78	0,5	FAK	58,61	GRP78	FAK	3309	5747	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	GRP78 promotes the invasion of pancreatic_cancer cells by FAK and JNK .
21170590	0	GRP78	37,42	GRP78	67,72	GRP78	GRP78	3309	3309	Gene	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	Betanodavirus up-regulates chaperone GRP78 via ER stress : roles of GRP78 in viral replication and host mitochondria-mediated cell death .
21170590	0	GRP78	67,72	GRP78	37,42	GRP78	GRP78	3309	3309	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	Betanodavirus up-regulates chaperone GRP78 via ER stress : roles of GRP78 in viral replication and host mitochondria-mediated cell death .
18083346	0	GRP78	22,27	HSP105	0,6	GRP78	HSP105	3309	10808	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation .
22751133	0	GRP78	14,19	IGFBP-3	0,7	GRP78	IGFBP-3	3309	3486	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	IGFBP-3 binds GRP78 , stimulates autophagy and promotes the survival of breast_cancer cells exposed to adverse microenvironments .
24516643	0	GRP78	51,56	PDK1	99,103	GRP78	PDK1	3309	5163	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
26104651	1	GRP78	87,92	VEGF	107,111	GRP78	VEGF	3309	7422	Gene	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	Changes of GRP78 and placental VEGF in preeclampsia .
20723363	0	GRP78	20,25	VP-16	63,68	GRP78	VP-16	3309	3054	Gene	Gene	Sensitivity|compound|START_ENTITY Sensitivity|nmod|END_ENTITY	-LSB- Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung_Adenocarcinoma . -RSB- .
15111246	0	GRP78	46,51	glucose-regulated_protein	19,44	GRP78	glucose-regulated protein	25617(Tax:10116)	25617(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of 78 kD glucose-regulated_protein -LRB- GRP78 -RRB- expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells .
23280503	0	GRP78	25,30	glucose-regulated_protein	32,57	GRP78	glucose-regulated protein	3309	3309	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	AKT inhibition mitigates GRP78 -LRB- glucose-regulated_protein -RRB- expression and contribution to chemoresistance in endometrial_cancers .
27016417	0	GRP78	128,133	glucose-regulated_protein_78	98,126	GRP78	glucose-regulated protein 78	3309	3309	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cancer-associated fibroblasts promote non-small_cell_lung_cancer cell invasion by upregulation of glucose-regulated_protein_78 -LRB- GRP78 -RRB- expression in an integrated bionic microfluidic device .
11687283	0	GRP78	61,66	glucose_regulated_protein	31,56	GRP78	glucose regulated protein	25617(Tax:10116)	25617(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Hypothermic treatment restores glucose_regulated_protein 78 -LRB- GRP78 -RRB- expression in ischemic brain .
24587347	0	GRP78	114,119	mTOR	91,95	GRP78	mTOR	3309	21977(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction .
24282526	0	GRP78	58,63	prostate_apoptosis_response_4	8,37	GRP78	prostate apoptosis response 4	3309	5074	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of prostate_apoptosis_response_4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells .
16806201	0	GRP78-binding_protein	0,21	glial_fibrillary_acidic_protein	45,76	GRP78-binding protein	glial fibrillary acidic protein	338474(Tax:10116)	24387(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	GRP78-binding_protein regulates cAMP-induced glial_fibrillary_acidic_protein expression in rat C6 glioblastoma cells .
2546060	0	GRP94	27,32	Glucose-regulated_protein	0,25	GRP94	Glucose-regulated protein	7184	7184	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Glucose-regulated_protein -LRB- GRP94 and GRP78 -RRB- genes share common regulatory domains and are coordinately regulated by common trans-acting factors .
15810071	0	GRP94	70,75	HSP27	35,40	GRP94	HSP27	7184	3315	Gene	Gene	HSP60|dep|START_ENTITY HSP60|compound|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
15390117	0	GRP94	100,105	HSP90	51,56	GRP94	HSP90	22027(Tax:10090)	104434(Tax:10090)	Gene	Gene	90-kDa_heat_shock_protein|appos|START_ENTITY 90-kDa_heat_shock_protein|appos|END_ENTITY	Glial expression of the 90-kDa_heat_shock_protein -LRB- HSP90 -RRB- and the 94-kDa_glucose-regulated_protein -LRB- GRP94 -RRB- following an excitotoxic lesion in the mouse hippocampus .
15810071	0	GRP94	70,75	HSP90	56,61	GRP94	HSP90	7184	3320	Gene	Gene	HSP60|dep|START_ENTITY HSP60|dep|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
10816560	0	GRP94	87,92	Hsp90	70,75	GRP94	Hsp90	7184	3320	Gene	Gene	chaperone|appos|START_ENTITY chaperone|amod|END_ENTITY	Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone , GRP94 .
10816561	0	GRP94	87,92	Hsp90	70,75	GRP94	Hsp90	7184	3320	Gene	Gene	chaperone|appos|START_ENTITY chaperone|amod|END_ENTITY	Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone , GRP94 .
15292259	0	GRP94	64,69	Hsp90	74,79	GRP94	Hsp90	7184	3320	Gene	Gene	START_ENTITY|appos|chaperone chaperone|amod|END_ENTITY	Ligand-induced conformational shift in the N-terminal domain of GRP94 , an Hsp90 chaperone .
16731965	0	GRP94	79,84	Hsp90	62,67	GRP94	Hsp90	7184	3320	Gene	Gene	chaperone|appos|START_ENTITY chaperone|amod|END_ENTITY	Identification of novel quaternary domain interactions in the Hsp90 chaperone , GRP94 .
9548957	0	GRP94	115,120	Hsp90	99,104	GRP94	Hsp90	7184	3320	Gene	Gene	chaperone|dobj|START_ENTITY chaperone|nsubj|transitions transitions|acl|accompanying accompanying|dobj|activation activation|nmod|END_ENTITY	Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94 .
3036833	0	GRP94	170,175	hsp90	121,126	GRP94	hsp90	7184	3320	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	ERp99 , an abundant , conserved glycoprotein of the endoplasmic reticulum , is homologous to the 90-kDa heat_shock protein -LRB- hsp90 -RRB- and the 94-kDa_glucose_regulated_protein -LRB- GRP94 -RRB- .
8617772	0	GRP94	19,24	p185erbB2	0,9	GRP94	p185erbB2	7184	2064	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	p185erbB2 binds to GRP94 in vivo .
22354143	0	GRPR	67,71	gastrin-releasing_peptide_receptor	31,65	GRPR	gastrin-releasing peptide receptor	2925	2925	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of fluorine-labeled gastrin-releasing_peptide_receptor -LRB- GRPR -RRB- agonists and antagonists by LC/MS .
9595551	0	GRP_78	66,72	glucose_regulated_protein	39,64	GRP 78	glucose regulated protein	3309	3309	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cell surface localization of the 78 kD glucose_regulated_protein -LRB- GRP_78 -RRB- induced by thapsigargin .
9495364	0	GRP_receptor	62,74	gastrin-releasing_peptide_receptor	26,60	GRP receptor	gastrin-releasing peptide receptor	2925	2925	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	In situ hybridization for gastrin-releasing_peptide_receptor -LRB- GRP_receptor -RRB- expression in prostatic_carcinoma .
23378141	0	GSC	46,49	goosecoid	35,44	GSC	goosecoid	145258	145258	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Chronic ethanol exposure increases goosecoid -LRB- GSC -RRB- expression in human embryonic_carcinoma cell differentiation .
20601164	0	GSDF	43,47	gonadal_soma_derived_factor	14,41	GSDF	gonadal soma derived factor	100415911	100415911	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of gonadal_soma_derived_factor -LRB- GSDF -RRB- is spatially and temporally correlated with early testicular differentiation in medaka .
9512666	0	GSH2	52,56	glutathione_synthetase	28,50	GSH2	glutathione synthetase	854108(Tax:4932)	854108(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular identification of glutathione_synthetase -LRB- GSH2 -RRB- gene from Saccharomyces_cerevisiae .
16230462	0	GSK-3	14,19	CRMP2	43,48	GSK-3	CRMP2	56637(Tax:10090)	12934(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of GSK-3 and phosphorylation of CRMP2 in transgenic_mice expressing APP intracellular domain .
9635432	0	GSK-3	21,26	GBP	0,3	GSK-3	GBP	399097(Tax:8355)	398043(Tax:8355)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	GBP , an inhibitor of GSK-3 , is implicated in Xenopus development and oncogenesis .
18167338	0	GSK-3_beta	0,10	Cdc25A	19,25	GSK-3 beta	Cdc25A	2932	993	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	GSK-3_beta targets Cdc25A for ubiquitin-mediated proteolysis , and GSK-3_beta inactivation correlates with Cdc25A overproduction in human cancers .
27049759	0	GSK-3a	0,6	CREB	28,32	GSK-3a	CREB	2931	1385	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	GSK-3a Is a Novel Target of CREB and CREB-GSK-3a Signaling Participates in Cell Viability in Lung_Cancer .
23358925	0	GSK-3a	55,61	glycogen_synthase_kinase_3a	26,53	GSK-3a	glycogen synthase kinase 3a	2931	2931	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of porcine glycogen_synthase_kinase_3a -LRB- GSK-3a -RRB- gene and its association with carcass traits .
22999562	0	GSK-3b	47,53	Akt	62,65	GSK-3b	Akt	2932	207	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Regulation of glycogen_synthase_kinase-3_beta -LRB- GSK-3b -RRB- by the Akt pathway in gliomas .
23010592	0	GSK-3b	25,31	Akt	84,87	GSK-3b	Akt	2932	207	Gene	Gene	Ser9|amod|START_ENTITY Ser9|acl|phosphorylation phosphorylation|nmod|END_ENTITY	NOK/STYK1 interacts with GSK-3b and mediates Ser9 phosphorylation through activated Akt .
24504086	0	GSK-3b	13,19	Akt	0,3	GSK-3b	Akt	84027(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Akt mediates GSK-3b phosphorylation in the rat prefrontal cortex during the process of ketamine exerting rapid antidepressant actions .
21549192	0	GSK-3b	0,6	CREB	7,11	GSK-3b	CREB	2932	1385	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|axis axis|compound|END_ENTITY	GSK-3b / CREB axis mediates IGF-1-induced ECM/adhesion molecule expression , cell cycle progression and monolayer permeability in retinal capillary endothelial cells : Implications for diabetic_retinopathy .
23266915	0	GSK-3b	133,139	CREB	85,89	GSK-3b	CREB	84027(Tax:10116)	81646(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Pretreatment of PC12 cells with 17b-estradiol prevents Ab-induced down-regulation of CREB phosphorylation and prolongs inhibition of GSK-3b .
26997328	0	GSK-3b	43,49	Glycogen_Synthase_Kinase-3b	14,41	GSK-3b	Glycogen Synthase Kinase-3b	84027(Tax:10116)	84027(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Glycogen_Synthase_Kinase-3b -LRB- GSK-3b -RRB- as potent therapeutic strategy to ameliorates L-dopa-induced_dyskinesia in 6-OHDA parkinsonian rats .
21441955	0	GSK-3b	23,29	K-Ras	7,12	GSK-3b	K-Ras	2932	3845	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Mutant K-Ras increases GSK-3b gene expression via an ETS-p300 transcriptional complex in pancreatic_cancer .
22114306	0	GSK-3b	15,21	M-cadherin	36,46	GSK-3b	M-cadherin	56637(Tax:10090)	12555(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Suppression of GSK-3b activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation .
22751450	0	GSK-3b	32,38	Mcl-1	18,23	GSK-3b	Mcl-1	2932	4170	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Downregulation of Mcl-1 through GSK-3b activation contributes to arsenic_trioxide-induced apoptosis in acute_myeloid_leukemia cells .
26823495	0	GSK-3b	0,6	NFATc2	36,42	GSK-3b	NFATc2	56637(Tax:10090)	18019(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	GSK-3b Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic_Cancer_Progression .
26838164	0	GSK-3b	0,6	Nrf2	21,25	GSK-3b	Nrf2	84027(Tax:10116)	83619(Tax:10116)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	GSK-3b downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral_ischemia-reperfusion .
23147208	0	GSK-3b	96,102	PI3K	71,75	GSK-3b	PI3K	84027(Tax:10116)	85243(Tax:10116)	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	Triiodothyronine -LRB- T3 -RRB- induces proinsulin gene expression by activating PI3K : possible roles for GSK-3b and the transcriptional factor PDX-1 .
26093674	0	GSK-3b	28,34	PI3K	0,4	GSK-3b	PI3K	2932	5293	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	PI3K mediated activation of GSK-3b reduces at-level primary afferent growth responses associated with excitotoxic spinal_cord_injury dysesthesias .
22999923	0	GSK-3b	80,86	PTEN	87,91	GSK-3b	PTEN	2932	5728	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3b / PTEN pathway .
26328540	0	GSK-3b	87,93	PTP1B	36,41	GSK-3b	PTP1B	56637(Tax:10090)	19246(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Combination of PKC Activation and PTP1B Inhibition Effectively Suppresses Ab-Induced GSK-3b Activation and Tau Phosphorylation .
21204008	0	GSK-3b	82,88	Progranulin	0,11	GSK-3b	Progranulin	2932	2896	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3b .
21383016	0	GSK-3b	80,86	glycogen_synthase_kinase-3b	51,78	GSK-3b	glycogen synthase kinase-3b	2932	2932	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	AMP-activated_protein_kinase -LRB- AMPK -RRB- activation and glycogen_synthase_kinase-3b -LRB- GSK-3b -RRB- inhibition induce Ca2 + - independent deposition of tight junction components at the plasma membrane .
26888388	0	GSK-3b	40,46	glycogen_synthase_kinase-3b	11,38	GSK-3b	glycogen synthase kinase-3b	84027(Tax:10116)	84027(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	-LSB- Impact of glycogen_synthase_kinase-3b -LRB- GSK-3b -RRB- inhibitor on Wnt and NF-kB signal pathways in a rat model of diabetic_nephropathy -RSB- .
22792253	0	GSK-3b	65,71	glycogen_synthase_kinase_3b	36,63	GSK-3b	glycogen synthase kinase 3b	100126852(Tax:9823)	100126852(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternative splicing of the porcine glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- gene with differential expression patterns and regulatory functions .
25151579	0	GSK-3b	177,183	glycogen_synthase_kinase_3b	148,175	GSK-3b	glycogen synthase kinase 3b	2932	2932	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Design , synthesis and biological evaluation of N-alkyl_or_aryl_substituted_isoindigo derivatives as potential dual cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- / glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- phosphorylation inhibitors .
26067173	0	GSK-3b	78,84	glycogen_synthase_kinase_3b	49,76	GSK-3b	glycogen synthase kinase 3b	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Radiosynthesis and preliminary PET evaluation of glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- inhibitors containing -LSB- -LRB- 11 -RRB- C -RSB- methylsulfanyl , -LSB- -LRB- 11 -RRB- C -RSB- methylsulfinyl or -LSB- -LRB- 11 -RRB- C -RSB- methylsulfonyl groups .
24025512	0	GSK-3b	49,55	leptin	27,33	GSK-3b	leptin	56637(Tax:10090)	16846(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	-LSB- APPL1-mediated effects of leptin on activity of GSK-3b in C2C12 cell -RSB- .
12147701	0	GSK-3beta	76,85	AKAP220	27,34	GSK-3beta	AKAP220	2932	11215	Gene	Gene	binds|nmod|START_ENTITY binds|compound|END_ENTITY	A-kinase anchoring protein AKAP220 binds to glycogen_synthase_kinase-3beta -LRB- GSK-3beta -RRB- and mediates protein kinase A-dependent inhibition of GSK-3beta .
12610628	0	GSK-3beta	16,25	Cdc42	0,5	GSK-3beta	Cdc42	84027(Tax:10116)	64465(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cdc42 regulates GSK-3beta and adenomatous_polyposis_coli to control cell polarity .
20399743	0	GSK-3beta	14,23	Galphaq	44,51	GSK-3beta	Galphaq	2932	2776	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of GSK-3beta and beta-Catenin by Galphaq in HEK293T cells .
18005231	0	GSK-3beta	0,9	Nrf2	50,54	GSK-3beta	Nrf2	2932	4780	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage : relevance to exposure of neuronal cells to oxidative stress .
17666435	0	GSK-3beta	0,9	PP2A	29,33	GSK-3beta	PP2A	2932	5524	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway , and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis .
18346908	0	GSK-3beta	22,31	TGF-beta1	0,9	GSK-3beta	TGF-beta1	2932	7040	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	TGF-beta1 targets the GSK-3beta / beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts .
10511426	0	GSK-3beta	91,100	beta-catenin	24,36	GSK-3beta	beta-catenin	56637(Tax:10090)	12387(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY correlates|nmod|levels correlates|nsubj|localization localization|nmod|END_ENTITY	Nuclear localization of beta-catenin in adult mouse thalamus correlates with low levels of GSK-3beta .
10699468	0	GSK-3beta	30,39	beta-catenin	8,20	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	displays|amod|START_ENTITY displays|amod|END_ENTITY	Nuclear beta-catenin displays GSK-3beta - and APC-independent proteasome sensitivity in melanoma cells .
11226152	0	GSK-3beta	82,91	beta-catenin	18,30	GSK-3beta	beta-catenin	56637(Tax:10090)	12387(Tax:10090)	Gene	Gene	conditional|amod|START_ENTITY transgenic_mice|amod|conditional hyperphosphorylation|nmod|transgenic_mice END_ENTITY|appos|hyperphosphorylation	Decreased nuclear beta-catenin , tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic_mice .
11313952	0	GSK-3beta	95,104	beta-catenin	32,44	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	inhibition|compound|START_ENTITY cascades|nmod|inhibition stimulate|nmod|cascades stimulate|dobj|pathway pathway|amod|END_ENTITY	Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation .
11738041	0	GSK-3beta	32,41	beta-catenin	92,104	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	structure|nmod|START_ENTITY complexed|nsubj|structure complexed|nmod|peptide peptide|acl:relcl|inhibits inhibits|dobj|phosphorylation phosphorylation|amod|END_ENTITY	The structure of phosphorylated GSK-3beta complexed with a peptide , FRATtide , that inhibits beta-catenin phosphorylation .
12969793	0	GSK-3beta	0,9	beta-catenin	44,56	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular_carcinoma .
16039586	0	GSK-3beta	31,40	beta-catenin	91,103	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	primes|dobj|START_ENTITY primes|nmod|inactivation inactivation|acl|resulting resulting|nmod|upregulation upregulation|nmod|END_ENTITY	Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin .
17968317	0	GSK-3beta	57,66	beta-catenin	21,33	GSK-3beta	beta-catenin	31248(Tax:7227)	31151(Tax:7227)	Gene	Gene	absence|nmod|START_ENTITY sequesters|nmod|absence sequesters|dobj|END_ENTITY	Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model .
18223684	0	GSK-3beta	8,17	beta-catenin	69,81	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|Wnt Wnt|acl|signalling signalling|nmod|manner manner|amod|END_ENTITY	Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner .
18346908	0	GSK-3beta	22,31	beta-catenin	32,44	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	targets|dobj|START_ENTITY targets|parataxis|activation activation|dep|pathway pathway|amod|END_ENTITY	TGF-beta1 targets the GSK-3beta / beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts .
18425851	0	GSK-3beta	0,9	beta-catenin	47,59	GSK-3beta	beta-catenin	399097(Tax:8355)	399274(Tax:8355)	Gene	Gene	regions|amod|START_ENTITY regions|nmod|effects effects|amod|END_ENTITY	GSK-3beta and alpha-catenin binding regions of beta-catenin exert opposing effects on the terminal ventral optic axonal projection .
18552505	0	GSK-3beta	58,67	beta-catenin	68,80	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	cascade|compound|START_ENTITY cascade|amod|END_ENTITY	HBx inhibits the growth of CCL13-HBX-stable cells via the GSK-3beta / beta-catenin cascade .
19228266	0	GSK-3beta	54,63	beta-catenin	136,148	GSK-3beta	beta-catenin	2932	1499	Gene	Gene	inhibitor|nmod|START_ENTITY 4-Aminoethylamino-emodin|dep|inhibitor acts|nsubj|4-Aminoethylamino-emodin acts|nmod|insulin-sensitizer insulin-sensitizer|acl|avoiding avoiding|dobj|effects effects|nmod|END_ENTITY	4-Aminoethylamino-emodin -- a novel potent inhibitor of GSK-3beta -- acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin .
19303025	0	GSK-3beta	62,71	beta-catenin	41,53	GSK-3beta	beta-catenin	56637(Tax:10090)	12387(Tax:10090)	Gene	Gene	accumulates|nmod|START_ENTITY accumulates|dobj|END_ENTITY	Caffeic_acid_phenethyl_ester accumulates beta-catenin through GSK-3beta and participates in proliferation through mTOR in C2C12 cells .
22672822	0	GSK-3beta	14,23	beta-catenin	90,102	GSK-3beta	beta-catenin	56637(Tax:10090)	12387(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY ameliorates|nsubj|Inhibition END_ENTITY|dep|ameliorates	Inhibition of GSK-3beta ameliorates hepatic_ischemia-reperfusion injury through GSK-3beta / beta-catenin signaling pathway in mice .
22672822	0	GSK-3beta	80,89	beta-catenin	90,102	GSK-3beta	beta-catenin	56637(Tax:10090)	12387(Tax:10090)	Gene	Gene	ameliorates|nmod|START_ENTITY END_ENTITY|dep|ameliorates	Inhibition of GSK-3beta ameliorates hepatic_ischemia-reperfusion injury through GSK-3beta / beta-catenin signaling pathway in mice .
17046823	0	GSK-3beta	15,24	cyclin_D1	100,109	GSK-3beta	cyclin D1	2932	595	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin_D1 in HeLa cells .
17560576	0	GSK-3beta	0,9	cyclin_D1	127,136	GSK-3beta	cyclin D1	56637(Tax:10090)	12443(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|nmod|localization localization|nmod|END_ENTITY	GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin_D2 nuclear localization and cell proliferation in cyclin_D1 - / - mouse uterine epithelium .
18023328	0	GSK-3beta	0,9	cyclin_D1	20,29	GSK-3beta	cyclin D1	2932	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	GSK-3beta regulates cyclin_D1 expression : a new target for chemotherapy .
18769147	0	GSK-3beta	0,9	cyclin_D1	95,104	GSK-3beta	cyclin D1	2932	595	Gene	Gene	inhibition|amod|START_ENTITY inhibition|dep|activation activation|acl|enhance enhance|dobj|stability stability|amod|END_ENTITY	GSK-3beta inhibition : at the crossroad between Akt and mTOR constitutive activation to enhance cyclin_D1 protein stability in mantle_cell_lymphoma .
15252116	0	GSK-3beta	63,72	cyclin_D3	28,37	GSK-3beta	cyclin D3	2932	896	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	cAMP-induced degradation of cyclin_D3 through association with GSK-3beta .
20827300	0	GSK-3beta	113,122	glycogen_synthase_kinase-3b	84,111	GSK-3beta	glycogen synthase kinase-3b	2932	2932	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Integrin-linked_kinase is a functional Mn2 + - dependent protein kinase that regulates glycogen_synthase_kinase-3b -LRB- GSK-3beta -RRB- phosphorylation .
17919914	0	GSK-3beta	52,61	glycogen_synthase_kinase_3beta	20,50	GSK-3beta	glycogen synthase kinase 3beta	2932	2932	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Non-ATP competitive glycogen_synthase_kinase_3beta -LRB- GSK-3beta -RRB- inhibitors : study of structural requirements for thiadiazolidinone derivatives .
18039685	0	GSK-3beta	118,127	myelin_basic_protein	174,194	GSK-3beta	myelin basic protein	2932	4155	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization of phospholipids , sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin_basic_protein in vitro .
19389373	0	GSK3	43,47	Akt	0,3	GSK3	Akt	56637(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Akt regulates skeletal development through GSK3 , mTOR , and FoxOs .
20460648	0	GSK3	21,25	Gbetagamma	0,10	GSK3	Gbetagamma	31248(Tax:7227)	35881(Tax:7227)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity .
22814108	0	GSK3	37,41	L-selectin	63,73	GSK3	L-selectin	56637(Tax:10090)	20343(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes .
19293931	0	GSK3	14,18	beta-catenin	38,50	GSK3	beta-catenin	399097(Tax:8355)	1499	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6 .
21208504	0	GSK3	63,67	glycogen_synthase_kinase-3	35,61	GSK3	glycogen synthase kinase-3	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Evidence for antimanic efficacy of glycogen_synthase_kinase-3 -LRB- GSK3 -RRB- inhibitors in a strain-specific model of acute mania .
22674256	0	GSK3	0,4	neurogenin_2	26,38	GSK3	neurogenin 2	56637(Tax:10090)	11924(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	GSK3 temporally regulates neurogenin_2 proneural activity in the neocortex .
25031575	0	GSK3-b	44,50	Glycogen_synthase_kinase_3-b	14,42	GSK3-b	Glycogen synthase kinase 3-b	2932	2932	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of Glycogen_synthase_kinase_3-b -LRB- GSK3-b -RRB- gene in azoospermic men .
18981097	0	GSK3-beta	86,95	IFN-beta	0,8	GSK3-beta	IFN-beta	56637(Tax:10090)	15977(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta .
20410116	0	GSK3_beta	0,9	CRMP4	71,76	GSK3 beta	CRMP4	2932	1809	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	GSK3_beta regulates myelin-dependent axon outgrowth inhibition through CRMP4 .
18353303	0	GSK3_beta	0,9	PKC_zeta	67,75	GSK3 beta	PKC zeta	2932	5590	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	GSK3_beta mediates acentromeric spindle stabilization by activated PKC_zeta .
17043650	0	GSK3_beta	0,9	PTEN	75,79	GSK3 beta	PTEN	56637(Tax:10090)	19211(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	GSK3_beta mediates suppression of cyclin_D2 expression by tumor suppressor PTEN .
26236947	0	GSK3b	34,39	AMPK	0,4	GSK3b	AMPK	2932	5564	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	AMPK inhibits MTDH expression via GSK3b and SIRT1 activation : potential role in triple_negative_breast_cancer cell proliferation .
26095393	0	GSK3b	14,19	BMP	31,34	GSK3b	BMP	2932	649	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Inhibition of GSK3b Stimulates BMP Signaling and Decreases SOST Expression Which Results in Enhanced Osteoblast Differentiation .
23583382	0	GSK3b	84,89	BTG2	49,53	GSK3b	BTG2	2932	7832	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Signals regulating necrosis of cardiomyoblast by BTG2 -LRB- / TIS21/PC3 -RRB- via activation of GSK3b and opening of mitochondrial permeability transition pore in response to H2O2 .
25451258	0	GSK3b	96,101	Brain_derived_neurotrophic_factor	0,33	GSK3b	Brain derived neurotrophic factor	2932	627	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	Brain_derived_neurotrophic_factor is involved in the regulation of glycogen_synthase_kinase_3b -LRB- GSK3b -RRB- signalling .
25145299	0	GSK3b	15,20	CXCR4	0,5	GSK3b	CXCR4	2932	7852	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	CXCR4 promotes GSK3b expression in pancreatic_cancer cells via the Akt pathway .
24134204	0	GSK3b	78,83	DYRK1B	49,55	GSK3b	DYRK1B	2932	9149	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3b to phosphorylate cyclin_D1 at Thr -LRB- 286 -RRB- , not Thr -LRB- 288 -RRB- .
25477508	0	GSK3b	65,70	Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A	75,136	GSK3b	Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A	56637(Tax:10090)	13548(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and Inactivation of Glycogen_Synthase_Kinase_3b -LRB- GSK3b -RRB- by Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A -LRB- Dyrk1A -RRB- .
25849320	0	GSK3b	16,21	FKBP51	0,6	GSK3b	FKBP51	2932	14229(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	FKBP51 inhibits GSK3b and augments the effects of distinct psychotropic medications .
26582204	0	GSK3b	47,52	GSKIP	31,36	GSK3b	GSKIP	56637(Tax:10090)	66787(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The A-kinase anchoring protein GSKIP regulates GSK3b activity and controls palatal shelf fusion in mice .
25334049	0	GSK3b	102,107	Glycogen_Synthase_Kinase-3b	73,100	GSK3b	Glycogen Synthase Kinase-3b	102176363	102176363	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Multiple Alternative Splicing and Differential Expression Pattern of the Glycogen_Synthase_Kinase-3b -LRB- GSK3b -RRB- Gene in Goat -LRB- Capra_hircus -RRB- .
25477508	0	GSK3b	65,70	Glycogen_Synthase_Kinase_3b	36,63	GSK3b	Glycogen Synthase Kinase 3b	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and Inactivation of Glycogen_Synthase_Kinase_3b -LRB- GSK3b -RRB- by Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A -LRB- Dyrk1A -RRB- .
23390016	0	GSK3b	29,34	Glycogen_synthase_kinase-3b	0,27	GSK3b	Glycogen synthase kinase-3b	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- expression in a mouse model of Alzheimer 's _ disease : a light and electron microscopy study .
24333432	0	GSK3b	0,5	HIF1a	27,32	GSK3b	HIF1a	2932	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	GSK3b negatively regulates HIF1a mRNA stability via nucleolin in the MG63 osteosarcoma cell line .
22384829	0	GSK3b	0,5	HNF4a	54,59	GSK3b	HNF4a	2932	3172	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	GSK3b regulates gluconeogenic gene expression through HNF4a and FOXO1 .
22960426	0	GSK3b	56,61	HNF4a	15,20	GSK3b	HNF4a	2932	3172	Gene	Gene	inactivation|amod|START_ENTITY activity|nmod|inactivation activity|amod|END_ENTITY	TGFb overrides HNF4a tumor suppressing activity through GSK3b inactivation : implication for hepatocellular_carcinoma gene therapy .
23085750	0	GSK3b	0,5	KLF6	29,33	GSK3b	KLF6	2932	1316	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|suppressor suppressor|compound|END_ENTITY	GSK3b phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21 .
26236947	0	GSK3b	34,39	MTDH	14,18	GSK3b	MTDH	2932	92140	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	AMPK inhibits MTDH expression via GSK3b and SIRT1 activation : potential role in triple_negative_breast_cancer cell proliferation .
23284807	0	GSK3b	18,23	Slit2	0,5	GSK3b	Slit2	2932	9353	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	Slit2 inactivates GSK3b to signal neurite outgrowth inhibition .
24134204	0	GSK3b	78,83	cyclin_D1	101,110	GSK3b	cyclin D1	2932	595	Gene	Gene	START_ENTITY|acl|phosphorylate phosphorylate|dobj|END_ENTITY	A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3b to phosphorylate cyclin_D1 at Thr -LRB- 286 -RRB- , not Thr -LRB- 288 -RRB- .
24218147	0	GSK3b	78,83	cyclin_D1	64,73	GSK3b	cyclin D1	84027(Tax:10116)	58919(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Perinatal exposure to BDE-99 causes decreased protein levels of cyclin_D1 via GSK3b activation and increased ROS production in rat pup livers .
22184106	0	GSK3b	115,120	glycogen_synthase_kinase-3b	86,113	GSK3b	glycogen synthase kinase-3b	2932	2932	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Prolyl isomerase Pin1 promotes amyloid_precursor_protein -LRB- APP -RRB- turnover by inhibiting glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- activity : novel mechanism for Pin1 to protect against Alzheimer_disease .
22489897	0	GSK3b	76,81	glycogen_synthase_kinase-3b	47,74	GSK3b	glycogen synthase kinase-3b	2932	2932	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Discovery of novel potent and highly selective glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- inhibitors for Alzheimer 's _ disease : design , synthesis , and characterization of pyrazines .
25461676	0	GSK3b	103,108	glycogen_synthase_kinase-3b	74,101	GSK3b	glycogen synthase kinase-3b	2932	2932	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple alternative splicing and differential expression patterns of the glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- gene in Schizothorax prenanti .
22266849	0	GSK3b	53,58	osteopontin	107,118	GSK3b	osteopontin	2932	6696	Gene	Gene	dephosphorylation|nmod|START_ENTITY mediated|dobj|dephosphorylation mediated|nmod|target target|appos|END_ENTITY	DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3b to downregulate b-catenin transcription target , osteopontin .
25565601	0	GSK3b	0,5	osteopontin	39,50	GSK3b	osteopontin	56637(Tax:10090)	20750(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	GSK3b negatively regulates LPS-induced osteopontin expression via inhibiting its transcription .
25331900	0	GSK3b	62,67	p25	23,26	GSK3b	p25	2932	8851	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	CDK5 activator protein p25 preferentially binds and activates GSK3b .
26045498	0	GSK3b	90,95	p25	51,54	GSK3b	p25	2932	8851	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|Correction Correction|nmod|END_ENTITY	Correction for Chow et al. , CDK5 activator protein p25 preferentially binds and activates GSK3b .
16981698	0	GSK3beta	101,109	Axin	27,31	GSK3beta	Axin	2932	8312	Gene	Gene	regulator|nmod|START_ENTITY homologous|nmod|regulator homologous|nmod|domain domain|compound|END_ENTITY	GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta .
16981698	0	GSK3beta	32,40	Axin	27,31	GSK3beta	Axin	2932	8312	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta .
19850033	0	GSK3beta	115,123	Axin	88,92	GSK3beta	Axin	31248(Tax:7227)	43565(Tax:7227)	Gene	Gene	interactions|nmod|START_ENTITY reveals|nmod|interactions reveals|dobj|requirements requirements|nmod|residues residues|nmod|END_ENTITY	In vivo analysis in Drosophila reveals differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin .
27045591	0	GSK3beta	36,44	Beta-Catenin	10,22	GSK3beta	Beta-Catenin	84027(Tax:10116)	84353(Tax:10116)	Gene	Gene	Cells|compound|START_ENTITY Activity|nmod|Cells Activity|amod|END_ENTITY	Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction .
15155564	0	GSK3beta	112,120	CREB	93,97	GSK3beta	CREB	2932	1385	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Reoxygenation after severe hypoxia induces cardiomyocyte_hypertrophy in vitro : activation of CREB downstream of GSK3beta .
15676027	0	GSK3beta	60,68	CRMP2	88,93	GSK3beta	CRMP2	56637(Tax:10090)	12934(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2 : implication of common phosphorylating mechanism underlying axon guidance and Alzheimer 's _ disease .
16981698	0	GSK3beta	101,109	GSK3beta	32,40	GSK3beta	GSK3beta	2932	2932	Gene	Gene	regulator|nmod|START_ENTITY homologous|nmod|regulator homologous|nmod|domain domain|compound|END_ENTITY	GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta .
16981698	0	GSK3beta	32,40	GSK3beta	101,109	GSK3beta	GSK3beta	2932	2932	Gene	Gene	domain|compound|START_ENTITY homologous|nmod|domain homologous|nmod|regulator regulator|nmod|END_ENTITY	GSKIP is homologous to the Axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta .
19830702	0	GSK3beta	23,31	GSKIP	0,5	GSK3beta	GSKIP	2932	51527	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	GSKIP , an inhibitor of GSK3beta , mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells .
19107203	0	GSK3beta	21,29	LRP6	74,78	GSK3beta	LRP6	399097(Tax:8355)	378494(Tax:8355)	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling .
19740771	0	GSK3beta	0,8	MAML1	68,73	GSK3beta	MAML1	2932	9794	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	GSK3beta is a negative regulator of the transcriptional coactivator MAML1 .
14622124	0	GSK3beta	46,54	MAP1B	37,42	GSK3beta	MAP1B	84027(Tax:10116)	29456(Tax:10116)	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
15737742	0	GSK3beta	56,64	MAP1B	98,103	GSK3beta	MAP1B	84027(Tax:10116)	29456(Tax:10116)	Gene	Gene	START_ENTITY|acl:relcl|enables enables|xcomp|phosphorylate phosphorylate|dobj|END_ENTITY	The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth .
16949836	0	GSK3beta	112,120	MAP1B	145,150	GSK3beta	MAP1B	31248(Tax:7227)	5740544(Tax:7227)	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The Drosophila microtubule associated protein Futsch is phosphorylated by Shaggy/Zeste-white _ 3 at an homologous GSK3beta phosphorylation site in MAP1B .
14622124	0	GSK3beta	46,54	NGF	0,3	GSK3beta	NGF	84027(Tax:10116)	310738(Tax:10116)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
19622347	0	GSK3beta	14,22	Sufu	0,4	GSK3beta	Sufu	2932	51684	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Sufu recruits GSK3beta for efficient processing of Gli3 .
14622124	0	GSK3beta	46,54	TrkA	67,71	GSK3beta	TrkA	84027(Tax:10116)	59109(Tax:10116)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
17949411	0	GSK3beta	0,8	acetylcholinesterase	53,73	GSK3beta	acetylcholinesterase	84027(Tax:10116)	83817(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	GSK3beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis .
10581160	0	GSK3beta	2,10	axin	35,39	GSK3beta	axin	2932	8312	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression .
19675674	0	GSK3beta	0,8	beta-catenin	38,50	GSK3beta	beta-catenin	2932	1499	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|inhibition inhibition|amod|END_ENTITY	GSK3beta is involved in JNK2-mediated beta-catenin inhibition .
12951189	0	GSK3beta	65,73	glycogen_synthase_kinase-3beta	33,63	GSK3beta	glycogen synthase kinase-3beta	100348842(Tax:9986)	100348842(Tax:9986)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Prenatal cocaine exposure alters glycogen_synthase_kinase-3beta -LRB- GSK3beta -RRB- pathway in select rabbit brain areas .
17018141	0	GSK3beta	41,49	glycogen_synthase_kinase_3_beta	8,39	GSK3beta	glycogen synthase kinase 3 beta	2932	2932	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of glycogen_synthase_kinase_3_beta -LRB- GSK3beta -RRB- in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin_A -LRB- TSA -RRB- in MCF-7_breast_cancer cells .
17046157	0	GSK3beta	55,63	glycogen_synthase_kinase_3beta	23,53	GSK3beta	glycogen synthase kinase 3beta	84027(Tax:10116)	84027(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Age-related changes in glycogen_synthase_kinase_3beta -LRB- GSK3beta -RRB- immunoreactivity in the central nervous system of rats .
24550987	0	GSK3beta	25,33	hnRNPA1	62,69	GSK3beta	hnRNPA1	2932	3178	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	AR-A_014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors .
26582204	0	GSKIP	31,36	GSK3b	47,52	GSKIP	GSK3b	66787(Tax:10090)	56637(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The A-kinase anchoring protein GSKIP regulates GSK3b activity and controls palatal shelf fusion in mice .
19830702	0	GSKIP	0,5	GSK3beta	23,31	GSKIP	GSK3beta	51527	2932	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	GSKIP , an inhibitor of GSK3beta , mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells .
21803734	0	GST	27,30	Glutathione_S-transferase	0,25	GST	Glutathione S-transferase	373156	373156	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glutathione_S-transferase -LRB- GST -RRB- gene polymorphisms , cigarette smoking and colorectal_cancer risk among Chinese in Singapore .
23105984	0	GST	51,54	Glutathione_S_Transferase	24,49	GST	Glutathione S Transferase	373156	373156	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Investigate the Role of Glutathione_S_Transferase -LRB- GST -RRB- Polymorphism in Development of Hypertension in UAE Population .
18544910	0	GST	79,82	N-acetyltransferase_2	11,32	GST	N-acetyltransferase 2	373156	10	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of N-acetyltransferase_2 -LRB- NAT2 -RRB- , CYP2E1 and Glutathione-S-transferase -LRB- GST -RRB- genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients .
10773456	0	GST	77,80	glutathione-S-transferase	50,75	GST	glutathione-S-transferase	36927(Tax:7227)	36927(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a new theta-class glutathione-S-transferase -LRB- GST -RRB- gene , gst-3 , from Drosophila_melanogaster .
23644668	0	GST	126,129	glutathione-S-transferase	99,124	GST	glutathione-S-transferase	373156	373156	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The responses of the hepatosomatic index -LRB- HSI -RRB- , 7-ethoxyresorufin-O-deethylase -LRB- EROD -RRB- activity and glutathione-S-transferase -LRB- GST -RRB- activity in sea bass -LRB- Dicentrarchus labrax , Linnaeus 1758 -RRB- caged at a polluted site : implications for their use in environmental risk assessment .
23878968	0	GST	76,79	glutathione-S-transferase	49,74	GST	glutathione-S-transferase	373156	373156	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Isolation , cloning and large scale expression of glutathione-S-transferase -LRB- GST -RRB- protein of Polymyxa betae .
26078397	0	GST	40,43	glutathione-S-transferase	13,38	GST	glutathione-S-transferase	54486(Tax:10090)	54486(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Influence of glutathione-S-transferase -LRB- GST -RRB- inhibition on lung epithelial cell injury : role of oxidative stress and metabolism .
19424424	0	GST	152,155	glutathione-S_transferase	125,150	GST	glutathione-S transferase	373156	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Linkage disequilibrium between two high-frequency deletion polymorphisms : implications for association studies involving the glutathione-S_transferase -LRB- GST -RRB- genes .
12408568	0	GST	92,95	glutathione_S-transferase	56,81	GST	glutathione S-transferase	373156	373156	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of three fungicides alone and in combination on glutathione_S-transferase activity -LRB- GST -RRB- and cytochrome_P-450 _ -LRB- CYP_1A1 -RRB- in the liver and gill of brown trout -LRB- Salmo trutta -RRB- .
1399740	0	GST	58,61	glutathione_S-transferase	31,56	GST	glutathione S-transferase	373156	373156	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Cellular glutathione -LRB- GSH -RRB- and glutathione_S-transferase -LRB- GST -RRB- activity in human ovarian_tumor biopsies following exposure to alkylating agents .
1635913	0	GST	36,39	glutathione_S-transferase	9,34	GST	glutathione S-transferase	58962(Tax:10116)	58962(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Enhanced glutathione_S-transferase -LRB- GST -RRB- activity in pregnant rats treated with benzo -LRB- a -RRB- pyrene .
18094897	0	GST	73,76	glutathione_S-transferase	46,71	GST	glutathione S-transferase	373156	373156	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Comparative analysis of the prevalence of the glutathione_S-transferase -LRB- GST -RRB- system in malignant and benign_thyroid_tumor cells .
19917083	0	GST	54,57	glutathione_S-transferase	27,52	GST	glutathione S-transferase	373156	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Examination of polymorphic glutathione_S-transferase -LRB- GST -RRB- genes , tobacco smoking and prostate_cancer risk among men of African descent : a case-control study .
21276481	0	GST	107,110	glutathione_S-transferase	80,105	GST	glutathione S-transferase	36927(Tax:7227)	36927(Tax:7227)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Identification , characterization and expression profiles of Chironomus riparius glutathione_S-transferase -LRB- GST -RRB- genes in response to cadmium and silver nanoparticles exposure .
21458595	0	GST	39,42	glutathione_S-transferase	12,37	GST	glutathione S-transferase	373156	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Response of glutathione_S-transferase -LRB- GST -RRB- genes to cadmium exposure in the marine pollution indicator worm , Perinereis nuntia .
7639695	0	GST	65,68	glutathione_S-transferase	38,63	GST	glutathione S-transferase	373156	373156	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Octopus S-crystallins with endogenous glutathione_S-transferase -LRB- GST -RRB- activity : sequence comparison and evolutionary relationships with authentic GST enzymes .
7937598	0	GST	44,47	glutathione_S-transferase	17,42	GST	glutathione S-transferase	58962(Tax:10116)	58962(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Modifications of glutathione_S-transferase -LRB- GST -RRB- activity in the last period of pregnancy in rats treated with benzo -LRB- a -RRB- pyrene -LRB- BP -RRB- .
10773456	0	GST	77,80	gst-3	88,93	GST	gst-3	36927(Tax:7227)	37106(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a new theta-class glutathione-S-transferase -LRB- GST -RRB- gene , gst-3 , from Drosophila_melanogaster .
24075358	0	GSTA1	0,5	GSTM1	7,12	GSTA1	GSTM1	2938	2944	Gene	Gene	polymorphisms|advmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	GSTA1 , GSTM1 , GSTP1 , and GSTT1 polymorphisms and susceptibility to smoking-related bladder_cancer : a case-control study .
20445800	0	GSTM1	67,72	CAT	81,84	GSTM1	CAT	2944	847	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
25436036	0	GSTM1	18,23	CAT	0,3	GSTM1	CAT	2944	847	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
11833070	0	GSTM1	39,44	CYP1A1	32,38	GSTM1	CYP1A1	2944	1543	Gene	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal_cancer in Xi'an .
15064998	0	GSTM1	89,94	CYP1A1	73,79	GSTM1	CYP1A1	2944	1543	Gene	Gene	CYP2E1|nummod|START_ENTITY END_ENTITY|appos|CYP2E1	Relationship between genetic polymorphisms of drug-metabolizing enzymes -LRB- CYP1A1 , CYP2E1 , GSTM1 , and NAT2 -RRB- , drinking habits , histological subtypes , and p53 gene point mutations in Japanese patients with gastric_cancer .
15298956	0	GSTM1	116,121	CYP1A1	108,114	GSTM1	CYP1A1	2944	1543	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Benzo -LRB- a -RRB- pyrene_diolepoxide -LRB- BPDE -RRB- - DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1 , GSTM1 , GSTP1 , GSTT1 , and mEH .
16466991	0	GSTM1	25,30	CYP1A1	17,23	GSTM1	CYP1A1	2944	1543	Gene	Gene	GSTT1|dep|START_ENTITY GSTT1|compound|END_ENTITY	Polymorphisms of CYP1A1 , GSTM1 , GSTT1 , and prostate_cancer risk in Turkish population .
16582078	0	GSTM1	40,45	CYP1A1	82,88	GSTM1	CYP1A1	2944	1543	Gene	Gene	glutathione-S-transferase|appos|START_ENTITY glutathione-S-transferase|appos|END_ENTITY	Influence of glutathione-S-transferase -LRB- GSTM1 , GSTP1 , GSTT1 -RRB- and cytochrome p450 -LRB- CYP1A1 , CYP2D6 -RRB- polymorphisms on numbers of basal_cell_carcinomas -LRB- BCCs -RRB- in families with the naevoid_basal_cell_carcinoma_syndrome .
20373852	0	GSTM1	70,75	CYP1A1	30,36	GSTM1	CYP1A1	2944	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21211368	0	GSTM1	61,66	CYP1A1	1,7	GSTM1	CYP1A1	2944	1543	Gene	Gene	lack|appos|START_ENTITY polymorphisms|appos|lack polymorphisms|compound|END_ENTITY	-LSB- CYP1A1 polymorphisms , lack of glutathione_S-transferase M1 -LRB- GSTM1 -RRB- , cooking oil fumes and lung_cancer risk in non-smoking women -RSB- .
24084344	0	GSTM1	133,138	CYP1A1	110,116	GSTM1	CYP1A1	2944	1543	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
18690546	0	GSTM1	16,21	CYP1A2	0,6	GSTM1	CYP1A2	2944	1544	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|compound|END_ENTITY	CYP1A2 , CYP2D6 , GSTM1 , GSTP1 , and GSTT1 gene polymorphisms in patients with bladder_cancer in a Turkish population .
24084344	0	GSTM1	133,138	CYP1B1	118,124	GSTM1	CYP1B1	2944	1545	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
12365037	0	GSTM1	33,38	CYP1a1	17,23	GSTM1	CYP1a1	2944	1543	Gene	Gene	CYP2e1|nummod|START_ENTITY CYP2e1|compound|END_ENTITY	Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians .
20373852	0	GSTM1	70,75	CYP2C19	46,53	GSTM1	CYP2C19	2944	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	GSTM1	70,75	CYP2C9	38,44	GSTM1	CYP2C9	2944	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
16160620	0	GSTM1	26,31	CYP2D6	45,51	GSTM1	CYP2D6	2944	1565	Gene	Gene	CYP3A5|compound|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
16582078	0	GSTM1	40,45	CYP2D6	90,96	GSTM1	CYP2D6	2944	1565	Gene	Gene	glutathione-S-transferase|appos|START_ENTITY glutathione-S-transferase|appos|CYP1A1 CYP1A1|dep|END_ENTITY	Influence of glutathione-S-transferase -LRB- GSTM1 , GSTP1 , GSTT1 -RRB- and cytochrome p450 -LRB- CYP1A1 , CYP2D6 -RRB- polymorphisms on numbers of basal_cell_carcinomas -LRB- BCCs -RRB- in families with the naevoid_basal_cell_carcinoma_syndrome .
18690546	0	GSTM1	16,21	CYP2D6	8,14	GSTM1	CYP2D6	2944	1565	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|appos|END_ENTITY	CYP1A2 , CYP2D6 , GSTM1 , GSTP1 , and GSTT1 gene polymorphisms in patients with bladder_cancer in a Turkish population .
20373852	0	GSTM1	70,75	CYP2D6	55,61	GSTM1	CYP2D6	2944	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20851451	0	GSTM1	47,52	CYP2D6	24,30	GSTM1	CYP2D6	2944	1565	Gene	Gene	T|nummod|START_ENTITY _|dobj|T _|nsubj|polymorphism polymorphism|nmod|C C|nummod|2 2|compound|END_ENTITY	Genetic polymorphism of CYP2D6 2 C _ > _ T 2850 , GSTM1 , NQO1 genes and their correlation with biomarkers in manganese miners of Central India .
24084344	0	GSTM1	133,138	EPHX1	126,131	GSTM1	EPHX1	2944	2052	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Cytogenetic damage in Turkish coke oven workers exposed to polycyclic_aromatic_hydrocarbons : Association with CYP1A1 , CYP1B1 , EPHX1 , GSTM1 , GSTT1 , and GSTP1 gene polymorphisms .
25436036	0	GSTM1	18,23	GPX1	5,9	GSTM1	GPX1	2944	2876	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
24075358	0	GSTM1	7,12	GSTA1	0,5	GSTM1	GSTA1	2944	2938	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|advmod|END_ENTITY	GSTA1 , GSTM1 , GSTP1 , and GSTT1 polymorphisms and susceptibility to smoking-related bladder_cancer : a case-control study .
15298956	0	GSTM1	116,121	GSTP1	123,128	GSTM1	GSTP1	2944	2950	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Benzo -LRB- a -RRB- pyrene_diolepoxide -LRB- BPDE -RRB- - DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1 , GSTM1 , GSTP1 , GSTT1 , and mEH .
16760134	0	GSTM1	25,30	GSTP1	39,44	GSTM1	GSTP1	2944	2950	Gene	Gene	GSTM3|compound|START_ENTITY GSTM3|appos|END_ENTITY	Genetic polymorphisms in GSTM1 , GSTT1 , GSTP1 , GSTM3 and the susceptibility to gallbladder_cancer in North India .
11488937	0	GSTM1	95,100	GSTT1	115,120	GSTM1	GSTT1	2944	2952	Gene	Gene	mu|appos|START_ENTITY mu|appos|END_ENTITY	Increased risk for acute_myeloid_leukaemia in individuals with glutathione_S-transferase mu 1 -LRB- GSTM1 -RRB- and theta 1 -LRB- GSTT1 -RRB- gene defects .
12365037	0	GSTM1	33,38	GSTT1	40,45	GSTM1	GSTT1	2944	2952	Gene	Gene	CYP2e1|nummod|START_ENTITY CYP2e1|nummod|END_ENTITY	Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians .
12421502	0	GSTM1	26,31	GSTT1	33,38	GSTM1	GSTT1	2944	2952	Gene	Gene	relationship|nmod|START_ENTITY -LSB-|dobj|relationship polymorphisms|advcl|-LSB- polymorphisms|nsubj|gene gene|compound|END_ENTITY	-LSB- The relationship between GSTM1 , GSTT1 gene polymorphisms and susceptibility to sporadic colorectal_adenocarcinoma -RSB- .
16047490	0	GSTM1	32,37	GSTT1	25,30	GSTM1	GSTT1	2944	2952	Gene	Gene	MnSOD|appos|START_ENTITY MnSOD|compound|END_ENTITY	Genetic polymorphisms of GSTT1 , GSTM1 , GSTP1 , MnSOD , and catalase in nonhereditary chronic_pancreatitis : evidence of xenobiotic stress and impaired antioxidant capacity .
16160620	0	GSTM1	26,31	GSTT1	33,38	GSTM1	GSTT1	2944	2952	Gene	Gene	CYP3A5|compound|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
16760134	0	GSTM1	25,30	GSTT1	32,37	GSTM1	GSTT1	2944	2952	Gene	Gene	GSTM3|compound|START_ENTITY GSTM3|appos|END_ENTITY	Genetic polymorphisms in GSTM1 , GSTT1 , GSTP1 , GSTM3 and the susceptibility to gallbladder_cancer in North India .
17374652	0	GSTM1	0,5	GSTT1	7,12	GSTM1	GSTT1	2944	2952	Gene	Gene	polymorphisms|advmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	GSTM1 , GSTT1 , GSTP1 , and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans .
18280004	0	GSTM1	34,39	GSTT1	41,46	GSTM1	GSTT1	2944	2952	Gene	Gene	4|nummod|START_ENTITY 4|nummod|END_ENTITY	Influence of p53 codon 72 exon 4 , GSTM1 , GSTT1 and GSTP1 * B polymorphisms in lung_cancer risk in a Brazilian population .
18597073	0	GSTM1	40,45	GSTT1	18,23	GSTM1	GSTT1	2944	2952	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers .
18986377	0	GSTM1	49,54	GSTT1	56,61	GSTM1	GSTT1	2944	2952	Gene	Gene	PSTI|compound|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
19303722	0	GSTM1	21,26	GSTT1	28,33	GSTM1	GSTT1	2944	2952	Gene	Gene	CYP2A6|appos|START_ENTITY CYP2A6|appos|END_ENTITY	Association of NAT2 , GSTM1 , GSTT1 , CYP2A6 , and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder_cancer in Central China .
19662515	0	GSTM1	83,88	GSTT1	68,73	GSTM1	GSTT1	2944	2952	Gene	Gene	glutathione_S-transferase_T1|appos|START_ENTITY glutathione_S-transferase_T1|appos|END_ENTITY	Influence of genetic polymorphisms of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- and M1 -LRB- GSTM1 -RRB- on hematological parameters .
20074657	0	GSTM1	57,62	GSTT1	78,83	GSTM1	GSTT1	2944	2952	Gene	Gene	theta|appos|START_ENTITY theta|appos|END_ENTITY	A deletion polymorphism in glutathione-S-transferase_mu -LRB- GSTM1 -RRB- and/or theta -LRB- GSTT1 -RRB- is associated with an increased risk of toxicity after autologous blood and marrow transplantation .
20301895	0	GSTM1	75,80	GSTT1	82,87	GSTM1	GSTT1	2944	2952	Gene	Gene	START_ENTITY|dep|CAT CAT|compound|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20373852	0	GSTM1	70,75	GSTT1	63,68	GSTM1	GSTT1	2944	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20445800	0	GSTM1	67,72	GSTT1	74,79	GSTM1	GSTT1	2944	2952	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
20621079	7	GSTM1	837,842	GSTT1	844,849	GSTM1	GSTT1	2944	2952	Gene	Gene	Subjects|nmod|START_ENTITY Subjects|dep|+ +|compound|END_ENTITY	Subjects with GSTM1 - / GSTT1 + , GSTM1 + / GSTT1 - , GSTM1 - / GSTT1 - have significant differences of oxidative stress markers as compared to GSTM1 + / GSTT1 + genotype .
20674986	0	GSTM1	69,74	GSTT1	84,89	GSTM1	GSTT1	2944	2952	Gene	Gene	M1|appos|START_ENTITY M1|appos|END_ENTITY	Bipolar_disorder and polymorphisms of glutathione_S-transferases M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- .
20708344	0	GSTM1	68,73	GSTT1	75,80	GSTM1	GSTT1	2944	2952	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
21701824	0	GSTM1	93,98	GSTT1	108,113	GSTM1	GSTT1	2944	2952	Gene	Gene	M1|appos|START_ENTITY M1|appos|END_ENTITY	Age-related macular_degeneration and genetic polymorphisms of glutathione_S-transferases M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- .
22377702	0	GSTM1	106,111	GSTT1	0,5	GSTM1	GSTT1	2944	2952	Gene	Gene	genotype|nummod|START_ENTITY confer|nsubj|genotype factor|advcl|confer factor|nsubj|genotype genotype|nummod|END_ENTITY	GSTT1 null genotype is a risk factor for diabetic_retinopathy in Caucasians with type 2 diabetes , whereas GSTM1 null genotype might confer protection against retinopathy .
22539183	0	GSTM1	70,75	GSTT1	55,60	GSTM1	GSTT1	2944	2952	Gene	Gene	glutathione_S-transferase_T1|appos|START_ENTITY glutathione_S-transferase_T1|appos|END_ENTITY	Genetic polymorphisms of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- and M1 -LRB- GSTM1 -RRB- in selected populations of Afghanistan .
22652274	0	GSTM1	12,17	GSTT1	19,24	GSTM1	GSTT1	2944	2952	Gene	Gene	GSTP1|compound|START_ENTITY GSTP1|appos|END_ENTITY	The role of GSTM1 , GSTT1 , GSTP1 , and OGG1 polymorphisms in type_2_diabetes_mellitus risk : a case-control study in a Turkish population .
22788240	0	GSTM1	34,39	GSTT1	41,46	GSTM1	GSTT1	2944	2952	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|appos|END_ENTITY	Genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors is associated with adverse reactions to anti-tuberculosis drugs .
23570881	0	GSTM1	0,5	GSTT1	7,12	GSTM1	GSTT1	2944	2952	Gene	Gene	GSTP1|compound|START_ENTITY GSTP1|appos|END_ENTITY	GSTM1 , GSTT1 , GSTP1 , and GSTA1 genetic variants are not associated with coronary_artery_disease in Taiwan .
23873097	0	GSTM1	19,24	GSTT1	12,17	GSTM1	GSTT1	2944	2952	Gene	Gene	Association|nummod|START_ENTITY Association|nummod|END_ENTITY	Association GSTT1 , GSTM1 and GSTP1 -LRB- Ile105Val -RRB- genetic polymorphisms in mothers with risk of congenital_malformations in their children in Western Siberia : a case-control study .
24375038	0	GSTM1	99,104	GSTT1	58,63	GSTM1	GSTT1	2944	2952	Gene	Gene	glutathione_S-transferase_T1|appos|START_ENTITY glutathione_S-transferase_T1|appos|END_ENTITY	Is there any association of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- and glutathione_S-transferase M1 -LRB- GSTM1 -RRB- gene polymorphism with gastric_cancers ?
24532428	0	GSTM1	47,52	GSTT1	62,67	GSTM1	GSTT1	2944	2952	Gene	Gene	glutathione_S-transferase_M1|appos|START_ENTITY glutathione_S-transferase_M1|appos|END_ENTITY	Polymorphisms of glutathione_S-transferase_M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- in ovarian_cancer risk .
25432281	0	GSTM1	38,43	GSTT1	53,58	GSTM1	GSTT1	2944	2952	Gene	Gene	Glutathione-S-Transferase_M1|appos|START_ENTITY Glutathione-S-Transferase_M1|appos|END_ENTITY	Role of Glutathione-S-Transferase_M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- Genes in the Development and Progress of Chronic_Myeloid_Leukemia and in the Formation of Response to Imatinib Therapy .
25461363	0	GSTM1	47,52	GSTT1	62,67	GSTM1	GSTT1	2944	2952	Gene	Gene	glutathione_S-transferase_M1|appos|START_ENTITY glutathione_S-transferase_M1|appos|END_ENTITY	Polymorphisms of glutathione_S-transferase_M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- and endometriosis risk : a meta-analysis .
26125851	0	GSTM1	37,42	GSTT1	44,49	GSTM1	GSTT1	2944	2952	Gene	Gene	GSTP1|compound|START_ENTITY GSTP1|appos|END_ENTITY	Short Communication Polymorphisms in GSTM1 , GSTT1 , GSTP1 , and GSTM3 genes and breast_cancer risk in northeastern Mexico .
26811816	0	GSTM1	77,82	GSTT1	62,67	GSTM1	GSTT1	2944	2952	Gene	Gene	Glutathione_S-Transferase_T1|appos|START_ENTITY Glutathione_S-Transferase_T1|appos|END_ENTITY	Prevalence of Null Genotypes of Glutathione_S-Transferase_T1 -LRB- GSTT1 -RRB- and M1 -LRB- GSTM1 -RRB- in Seven Iranian Populations .
8001244	0	GSTM1	114,119	GSTT1	38,43	GSTM1	GSTT1	2944	2952	Gene	Gene	interactions|nmod|START_ENTITY genotypes|dep|interactions genotypes|compound|END_ENTITY	Theta class glutathione_S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia : interactions with GSTM1 , CYP2D6 and smoking .
8625505	0	GSTM1	101,106	GSTT1	26,31	GSTM1	GSTT1	2944	2952	Gene	Gene	interactions|nmod|START_ENTITY studies|nmod|interactions genotypes|dep|studies genotypes|compound|END_ENTITY	Glutathione_S-transferase GSTT1 genotypes and susceptibility to cancer : studies of interactions with GSTM1 in lung , oral , gastric and colorectal_cancers .
9788723	0	GSTM1	84,89	GSTT1	102,107	GSTM1	GSTT1	2944	2952	Gene	Gene	glutathione_S-transferase_mu|appos|START_ENTITY glutathione_S-transferase_mu|appos|END_ENTITY	Prevalence of homozygosity for the deleted alleles of glutathione_S-transferase_mu -LRB- GSTM1 -RRB- and theta -LRB- GSTT1 -RRB- among distinct ethnic groups from Brazil : relevance to environmental_carcinogenesis ?
24840051	0	GSTM1	46,51	Glutathione_S-transferase	0,25	GSTM1	Glutathione S-transferase	2944	373156	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|amod|END_ENTITY	Glutathione_S-transferase gene polymorphisms -LRB- GSTM1 , GSTT1 , and GSTP1 -RRB- in Egyptian pediatric patients with sickle_cell_disease .
18986377	0	GSTM1	49,54	LPL	75,78	GSTM1	LPL	2944	4023	Gene	Gene	PSTI|compound|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20708344	0	GSTM1	68,73	MLH1	88,92	GSTM1	MLH1	2944	4292	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	GSTM1	68,73	MSH2	82,86	GSTM1	MSH2	2944	4436	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20373852	0	GSTM1	70,75	MTHFR	77,82	GSTM1	MTHFR	2944	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	GSTM1	70,75	MTRR	84,88	GSTM1	MTRR	2944	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20301895	0	GSTM1	75,80	MnSOD	94,99	GSTM1	MnSOD	2944	6648	Gene	Gene	START_ENTITY|dep|GPX1 GPX1|compound|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20445800	0	GSTM1	67,72	MnSOD	86,91	GSTM1	MnSOD	2944	6648	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
25436036	0	GSTM1	18,23	MnSOD	11,16	GSTM1	MnSOD	2944	6648	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
16112301	0	GSTM1	23,28	NAT2	0,4	GSTM1	NAT2	2944	10	Gene	Gene	genotype|nummod|START_ENTITY acetylation|appos|genotype acetylation|nummod|END_ENTITY	NAT2 slow acetylation , GSTM1 null genotype , and risk of bladder_cancer : results from the Spanish Bladder_Cancer Study and meta-analyses .
18986377	0	GSTM1	49,54	NAT2	69,73	GSTM1	NAT2	2944	10	Gene	Gene	PSTI|compound|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
19303722	0	GSTM1	21,26	NAT2	15,19	GSTM1	NAT2	2944	10	Gene	Gene	CYP2A6|appos|START_ENTITY CYP2A6|compound|END_ENTITY	Association of NAT2 , GSTM1 , GSTT1 , CYP2A6 , and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder_cancer in Central China .
20373852	0	GSTM1	70,75	NAT2	96,100	GSTM1	NAT2	2944	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
22788240	0	GSTM1	34,39	NAT2	28,32	GSTM1	NAT2	2944	10	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|compound|END_ENTITY	Genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors is associated with adverse reactions to anti-tuberculosis drugs .
9891107	0	GSTM1	63,68	NAT2	23,27	GSTM1	NAT2	2944	10	Gene	Gene	START_ENTITY|nsubj|N-Acetyltransferase_2 N-Acetyltransferase_2|appos|END_ENTITY	N-Acetyltransferase_2 -LRB- NAT2 -RRB- and Glutathione_S-Transferase -LRB- GSTM1 -RRB- in Bladder-cancer Patients in a Highly Industrialized Area .
18986377	0	GSTM1	49,54	NQO1	63,67	GSTM1	NQO1	2944	1728	Gene	Gene	PSTI|compound|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20373852	0	GSTM1	70,75	NQO1	90,94	GSTM1	NQO1	2944	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
18986377	0	GSTM1	49,54	PRSS1	80,85	GSTM1	PRSS1	2944	5644	Gene	Gene	PSTI|compound|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
16160620	0	GSTM1	26,31	PgP	40,43	GSTM1	PgP	2944	283871	Gene	Gene	CYP3A5|compound|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
20708344	0	GSTM1	68,73	XPD	63,66	GSTM1	XPD	2944	2068	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	GSTM1	68,73	XRCC3	56,61	GSTM1	XRCC3	2944	7517	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
15565566	0	GSTM1	58,63	glutathione-S-transferase	25,50	GSTM1	glutathione-S-transferase	2944	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Genetic polymorphisms in glutathione-S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and survival after chemotherapy for invasive breast_carcinoma .
7844900	0	GSTM1	48,53	glutathione-S-transferase_M1	18,46	GSTM1	glutathione-S-transferase M1	2944	2944	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The frequency of glutathione-S-transferase_M1 -LRB- GSTM1 -RRB- gene deletion in patients with lung and oral_cancer -RSB- .
10779639	0	GSTM1	50,55	glutathione_S-transferase	17,42	GSTM1	glutathione S-transferase	2944	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Polymorphisms of glutathione_S-transferase genes -LRB- GSTM1 , GSTP1 and GSTT1 -RRB- and breast_cancer susceptibility .
20354063	0	GSTM1	57,62	glutathione_S-transferase	25,50	GSTM1	glutathione S-transferase	2944	373156	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|nmod|genes genes|amod|END_ENTITY	Genetic polymorphisms of glutathione_S-transferase genes GSTM1 , GSTT1 and risk of coronary_heart_disease .
23185284	0	GSTM1	57,62	glutathione_S-transferase	25,50	GSTM1	glutathione S-transferase	2944	373156	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|nmod|genes genes|amod|END_ENTITY	Genetic polymorphisms of glutathione_S-transferase genes GSTM1 , GSTT1 and risk of hepatocellular_carcinoma .
25969820	0	GSTM1	42,47	glutathione_S-transferase	15,40	GSTM1	glutathione S-transferase	2944	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Association of glutathione_S-transferase -LRB- GSTM1 and GSTT1 -RRB- genes with chronic_myeloid_leukemia .
8956789	0	GSTM1	86,91	p53	110,113	GSTM1	p53	2944	7157	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Epithelial_ovarian_cancer : influence of polymorphism at the glutathione_S-transferase GSTM1 and GSTT1 loci on p53 expression .
23888047	0	GSTO1-1	44,51	glutathione_transferase_Omega_1	11,42	GSTO1-1	glutathione transferase Omega 1	9446	9446	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for glutathione_transferase_Omega_1 -LRB- GSTO1-1 -RRB- in the glutathionylation cycle .
22893750	0	GSTP	25,29	XRCC1	18,23	GSTP	XRCC1	2950	7515	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of XPC , XPD , XRCC1 , GSTP genetic polymorphisms and Barrett 's _ esophagus in a cohort of Italian subjects .
15298956	0	GSTP1	123,128	CYP1A1	108,114	GSTP1	CYP1A1	2950	1543	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Benzo -LRB- a -RRB- pyrene_diolepoxide -LRB- BPDE -RRB- - DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1 , GSTM1 , GSTP1 , GSTT1 , and mEH .
16582078	0	GSTP1	47,52	CYP1A1	82,88	GSTP1	CYP1A1	2950	1543	Gene	Gene	GSTM1|dep|START_ENTITY glutathione-S-transferase|appos|GSTM1 glutathione-S-transferase|appos|END_ENTITY	Influence of glutathione-S-transferase -LRB- GSTM1 , GSTP1 , GSTT1 -RRB- and cytochrome p450 -LRB- CYP1A1 , CYP2D6 -RRB- polymorphisms on numbers of basal_cell_carcinomas -LRB- BCCs -RRB- in families with the naevoid_basal_cell_carcinoma_syndrome .
18992797	0	GSTP1	169,174	CYP1A1	115,121	GSTP1	CYP1A1	2950	1543	Gene	Gene	coexpression|compound|START_ENTITY presence|nmod|coexpression Cytotoxicity|nmod|presence Cytotoxicity|nmod|cells cells|acl|modified modified|xcomp|express express|dobj|END_ENTITY	Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1 , in the presence or absence of human GSTP1 coexpression .
22918668	0	GSTP1	61,66	CYP1A1	53,59	GSTP1	CYP1A1	2950	1543	Gene	Gene	GSTT1|compound|START_ENTITY END_ENTITY|dep|GSTT1	Expression patterns of carcinogen detoxifying genes -LRB- CYP1A1 , GSTP1 _ GSTT1 -RRB- in HNC patients .
21309732	0	GSTP1	22,27	EPHX1	15,20	GSTP1	EPHX1	2950	2052	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Correlation of EPHX1 , GSTP1 , GSTM1 , and GSTT1 genetic polymorphisms with antioxidative stress markers in chronic_obstructive_pulmonary_disease .
26314858	0	GSTP1	35,40	ERCC1	14,19	GSTP1	ERCC1	2950	2067	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
26314858	0	GSTP1	35,40	ERCC2	21,26	GSTP1	ERCC2	2950	2068	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
15298956	0	GSTP1	123,128	GSTM1	116,121	GSTP1	GSTM1	2950	2944	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Benzo -LRB- a -RRB- pyrene_diolepoxide -LRB- BPDE -RRB- - DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1 , GSTM1 , GSTP1 , GSTT1 , and mEH .
16760134	0	GSTP1	39,44	GSTM1	25,30	GSTP1	GSTM1	2950	2944	Gene	Gene	GSTM3|appos|START_ENTITY GSTM3|compound|END_ENTITY	Genetic polymorphisms in GSTM1 , GSTT1 , GSTP1 , GSTM3 and the susceptibility to gallbladder_cancer in North India .
10666194	0	GSTP1	68,73	GSTT1	61,66	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Polymorphisms within glutathione_S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and risk of relapse in childhood B-cell precursor acute_lymphoblastic_leukemia : a case-control study .
15565566	0	GSTP1	72,77	GSTT1	65,70	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Genetic polymorphisms in glutathione-S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and survival after chemotherapy for invasive breast_carcinoma .
16047490	0	GSTP1	39,44	GSTT1	25,30	GSTP1	GSTT1	2950	2952	Gene	Gene	MnSOD|appos|START_ENTITY MnSOD|compound|END_ENTITY	Genetic polymorphisms of GSTT1 , GSTM1 , GSTP1 , MnSOD , and catalase in nonhereditary chronic_pancreatitis : evidence of xenobiotic stress and impaired antioxidant capacity .
20505681	0	GSTP1	79,84	GSTT1	72,77	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	The association of glutathione-S-transferase gene polymorphisms -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- with idiopathic_male_infertility .
21243008	0	GSTP1	60,65	GSTT1	53,58	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Glutathione_S-transferase gene polymorphisms -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and prostate_cancer : a case-control study in Tehran , Iran .
22154357	0	GSTP1	80,85	GSTT1	73,78	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Association of genetic polymorphism of glutathione_S-transferase -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- with bladder_cancer susceptibility .
22903474	0	GSTP1	55,60	GSTT1	48,53	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Glutathione_S-transferase polymorphisms -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and male_factor_infertility risk : a pooled analysis of studies .
23014993	0	GSTP1	74,79	GSTT1	67,72	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Study of the association between glutathione_S-transferase -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- polymorphisms with type_II_diabetes_mellitus in southern of Iran .
25532576	0	GSTP1	79,84	GSTT1	72,77	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Association of polymorphisms in glutathione_S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- with idiopathic azoospermia or oligospermia in Sichuan , China .
26252359	0	GSTP1	83,88	GSTT1	76,81	GSTP1	GSTT1	2950	2952	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Effects of genetic polymorphisms of glutathione_S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- on the risk of diabetic_nephropathy : a meta-analysis .
21855532	0	GSTP1	31,36	Glutathione-S-transferase_pi_1	0,30	GSTP1	Glutathione-S-transferase pi 1	2950	2950	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glutathione-S-transferase_pi_1 -LRB- GSTP1 -RRB- gene silencing in prostate_cancer cells is reversed by the histone deacetylase inhibitor depsipeptide .
16176403	0	GSTP1	51,56	Glutathione_S-transferase_P1	21,49	GSTP1	Glutathione S-transferase P1	2950	2950	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Association study of Glutathione_S-transferase_P1 -LRB- GSTP1 -RRB- with asthma and bronchial hyper-responsiveness in two German pediatric populations .
24664677	0	GSTP1	38,43	Glutathione_S-transferase_pi_isoform	0,36	GSTP1	Glutathione S-transferase pi isoform	14870(Tax:10090)	14870(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glutathione_S-transferase_pi_isoform -LRB- GSTP1 -RRB- expression in murine retina increases with developmental maturity .
17424838	0	GSTP1	37,42	MPO	26,29	GSTP1	MPO	2950	4353	Gene	Gene	UGT1A6|appos|START_ENTITY UGT1A6|compound|END_ENTITY	-LSB- Genetic polymorphisms of MPO , NQO1 , GSTP1 , UGT1A6 associated with susceptibility of chronic benzene_poisoning -RSB- .
22202125	0	GSTP1	77,82	N-Myc	0,5	GSTP1	N-Myc	2950	4613	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1 , a marker of poor outcome in neuroblastoma .
26622888	0	GSTP1	57,62	P16	64,67	GSTP1	P16	2950	1029	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Detecting abnormal methylation of tumor suppressor genes GSTP1 , P16 , RIZ1 , and RASSF1A in hepatocellular_carcinoma and its clinical significance .
26622888	0	GSTP1	57,62	RIZ1	69,73	GSTP1	RIZ1	2950	7799	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Detecting abnormal methylation of tumor suppressor genes GSTP1 , P16 , RIZ1 , and RASSF1A in hepatocellular_carcinoma and its clinical significance .
23426146	0	GSTP1	0,5	Stat3	27,32	GSTP1	Stat3	2950	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	GSTP1 negatively regulates Stat3 activation in epidermal_growth_factor signaling .
26314858	0	GSTP1	35,40	XRCC1	28,33	GSTP1	XRCC1	2950	7515	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
23426146	0	GSTP1	0,5	epidermal_growth_factor	47,70	GSTP1	epidermal growth factor	2950	1950	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	GSTP1 negatively regulates Stat3 activation in epidermal_growth_factor signaling .
11307147	0	GSTP1	50,55	glutathione-S-transferase	17,42	GSTP1	glutathione-S-transferase	2950	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Polymorphisms of glutathione-S-transferase genes -LRB- GSTP1 , GSTM1 and GSTT1 -RRB- and prostate-cancer risk .
17593093	0	GSTP1	54,59	glutathione-S-transferase_P1	24,52	GSTP1	glutathione-S-transferase P1	2950	2950	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association analysis of glutathione-S-transferase_P1 -LRB- GSTP1 -RRB- polymorphism with urothelial_cancer susceptibility and myelosuppression after M-VAC chemotherapy .
22180037	0	GSTP1	63,68	glutathione-S-transferase_P1	28,56	GSTP1	glutathione-S-transferase P1	2950	2950	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphism of the glutathione-S-transferase_P1 gene -LRB- GSTP1 -RRB- and susceptibility to prostate_cancer in the Kashmiri population .
16039055	0	GSTP1	66,71	glutathione_S-transferase	39,64	GSTP1	glutathione S-transferase	2950	373156	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association study between a functional glutathione_S-transferase -LRB- GSTP1 -RRB- gene polymorphism -LRB- Ile105Val -RRB- and tardive_dyskinesia .
9511175	0	GSTP1	30,35	glutathione_S-transferase	4,29	GSTP1	glutathione S-transferase	2950	373156	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	The glutathione_S-transferase GSTP1 polymorphism : effects on susceptibility to oral/pharyngeal and laryngeal_carcinomas .
14719182	0	GSTP1	72,77	glutathione_S-transferase_P1	37,65	GSTP1	glutathione S-transferase P1	2950	2950	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between a variant of the glutathione_S-transferase_P1 gene -LRB- GSTP1 -RRB- and hypertension in pregnancy in Japanese : interaction with parity , age , and genetic factors .
22320983	0	GSTP1	84,89	glutathione_S-transferase_P1	49,77	GSTP1	glutathione S-transferase P1	2950	2950	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter methylation and genetic polymorphism of glutathione_S-transferase_P1 gene -LRB- GSTP1 -RRB- in Thai breast - _ cancer patients .
24205873	0	GSTP1	45,50	glutathione_S-transferase_P1	15,43	GSTP1	glutathione S-transferase P1	2950	2950	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of glutathione_S-transferase_P1 -LRB- GSTP1 -RRB- polymorphism with Tourette_syndrome in Taiwanese patients .
24117884	0	GSTP1	0,5	hub	11,14	GSTP1	hub	2950	1993	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma .
22068640	0	GSTP1-1	10,17	JNK	26,29	GSTP1-1	JNK	2950	5599	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and - resistant human osteosarcoma cell lines .
22047626	0	GSTP1-1	227,234	glutathione_S-transferase_P1-1	195,225	GSTP1-1	glutathione S-transferase P1-1	2950	2950	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Oral ezatiostat HCl -LRB- Telintra , TLK199 -RRB- and idiopathic_chronic_neutropenia -LRB- ICN -RRB- : a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat , a glutathione_S-transferase_P1-1 -LRB- GSTP1-1 -RRB- inhibitor .
20445800	0	GSTT1	74,79	CAT	81,84	GSTT1	CAT	2952	847	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
20373852	0	GSTT1	63,68	CYP1A1	30,36	GSTT1	CYP1A1	2952	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12365037	0	GSTT1	40,45	CYP1a1	17,23	GSTT1	CYP1a1	2952	1543	Gene	Gene	CYP2e1|nummod|START_ENTITY CYP2e1|compound|END_ENTITY	Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians .
20373852	0	GSTT1	63,68	CYP2C19	46,53	GSTT1	CYP2C19	2952	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	GSTT1	63,68	CYP2C9	38,44	GSTT1	CYP2C9	2952	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
11448648	0	GSTT1	134,139	CYP2D6	206,212	GSTT1	CYP2D6	2952	1565	Gene	Gene	genotype|compound|START_ENTITY genotype|dep|activity activity|nmod|genotype genotype|compound|END_ENTITY	Host determinants of DNA alkylation and DNA repair activity in human colorectal tissue : O -LRB- 6 -RRB- - methylguanine levels are associated with GSTT1 genotype and O -LRB- 6 -RRB- - alkylguanine-DNA alkyltransferase activity with CYP2D6 genotype .
16160620	0	GSTT1	33,38	CYP2D6	45,51	GSTT1	CYP2D6	2952	1565	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
20373852	0	GSTT1	63,68	CYP2D6	55,61	GSTT1	CYP2D6	2952	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
7671227	0	GSTT1	98,103	CYP2D6	137,143	GSTT1	CYP2D6	2952	1565	Gene	Gene	glutathione_S-transferase|dep|START_ENTITY loci|amod|glutathione_S-transferase loci|appos|END_ENTITY	Susceptibility to astrocytoma and meningioma : influence of allelism at glutathione_S-transferase -LRB- GSTT1 and GSTM1 -RRB- and cytochrome P-450 -LRB- CYP2D6 -RRB- loci .
25249451	0	GSTT1	26,31	DCC	15,18	GSTT1	DCC	2952	1630	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association of DCC , MLH1 , GSTT1 , GSTM1 , and TP53 gene polymorphisms with colorectal_cancer in Kazakhstan .
11488937	0	GSTT1	115,120	GSTM1	95,100	GSTT1	GSTM1	2952	2944	Gene	Gene	mu|appos|START_ENTITY mu|appos|END_ENTITY	Increased risk for acute_myeloid_leukaemia in individuals with glutathione_S-transferase mu 1 -LRB- GSTM1 -RRB- and theta 1 -LRB- GSTT1 -RRB- gene defects .
12365037	0	GSTT1	40,45	GSTM1	33,38	GSTT1	GSTM1	2952	2944	Gene	Gene	CYP2e1|nummod|START_ENTITY CYP2e1|nummod|END_ENTITY	Polymorphisms of CYP1a1 , CYP2e1 , GSTM1 , GSTT1 , and TP53 genes in Amerindians .
12421502	0	GSTT1	33,38	GSTM1	26,31	GSTT1	GSTM1	2952	2944	Gene	Gene	gene|compound|START_ENTITY polymorphisms|nsubj|gene polymorphisms|advcl|-LSB- -LSB-|dobj|relationship relationship|nmod|END_ENTITY	-LSB- The relationship between GSTM1 , GSTT1 gene polymorphisms and susceptibility to sporadic colorectal_adenocarcinoma -RSB- .
16047490	0	GSTT1	25,30	GSTM1	32,37	GSTT1	GSTM1	2952	2944	Gene	Gene	MnSOD|compound|START_ENTITY MnSOD|appos|END_ENTITY	Genetic polymorphisms of GSTT1 , GSTM1 , GSTP1 , MnSOD , and catalase in nonhereditary chronic_pancreatitis : evidence of xenobiotic stress and impaired antioxidant capacity .
16160620	0	GSTT1	33,38	GSTM1	26,31	GSTT1	GSTM1	2952	2944	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|compound|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
16760134	0	GSTT1	32,37	GSTM1	25,30	GSTT1	GSTM1	2952	2944	Gene	Gene	GSTM3|appos|START_ENTITY GSTM3|compound|END_ENTITY	Genetic polymorphisms in GSTM1 , GSTT1 , GSTP1 , GSTM3 and the susceptibility to gallbladder_cancer in North India .
17374652	0	GSTT1	7,12	GSTM1	0,5	GSTT1	GSTM1	2952	2944	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|advmod|END_ENTITY	GSTM1 , GSTT1 , GSTP1 , and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans .
18280004	0	GSTT1	41,46	GSTM1	34,39	GSTT1	GSTM1	2952	2944	Gene	Gene	4|nummod|START_ENTITY 4|nummod|END_ENTITY	Influence of p53 codon 72 exon 4 , GSTM1 , GSTT1 and GSTP1 * B polymorphisms in lung_cancer risk in a Brazilian population .
18597073	0	GSTT1	18,23	GSTM1	40,45	GSTT1	GSTM1	2952	2944	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Modulation of the GSTT1 activity by the GSTM1 phenotype in a sample of Italian farm-workers .
18986377	0	GSTT1	56,61	GSTM1	49,54	GSTT1	GSTM1	2952	2944	Gene	Gene	PSTI|appos|START_ENTITY PSTI|compound|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
19303722	0	GSTT1	28,33	GSTM1	21,26	GSTT1	GSTM1	2952	2944	Gene	Gene	CYP2A6|appos|START_ENTITY CYP2A6|appos|END_ENTITY	Association of NAT2 , GSTM1 , GSTT1 , CYP2A6 , and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder_cancer in Central China .
19662515	0	GSTT1	68,73	GSTM1	83,88	GSTT1	GSTM1	2952	2944	Gene	Gene	glutathione_S-transferase_T1|appos|START_ENTITY glutathione_S-transferase_T1|appos|END_ENTITY	Influence of genetic polymorphisms of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- and M1 -LRB- GSTM1 -RRB- on hematological parameters .
20074657	0	GSTT1	78,83	GSTM1	57,62	GSTT1	GSTM1	2952	2944	Gene	Gene	theta|appos|START_ENTITY theta|appos|END_ENTITY	A deletion polymorphism in glutathione-S-transferase_mu -LRB- GSTM1 -RRB- and/or theta -LRB- GSTT1 -RRB- is associated with an increased risk of toxicity after autologous blood and marrow transplantation .
20301895	0	GSTT1	82,87	GSTM1	75,80	GSTT1	GSTM1	2952	2944	Gene	Gene	CAT|compound|START_ENTITY END_ENTITY|dep|CAT	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20373852	0	GSTT1	63,68	GSTM1	70,75	GSTT1	GSTM1	2952	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20445800	0	GSTT1	74,79	GSTM1	67,72	GSTT1	GSTM1	2952	2944	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
20621079	7	GSTT1	844,849	GSTM1	837,842	GSTT1	GSTM1	2952	2944	Gene	Gene	+|compound|START_ENTITY Subjects|dep|+ Subjects|nmod|END_ENTITY	Subjects with GSTM1 - / GSTT1 + , GSTM1 + / GSTT1 - , GSTM1 - / GSTT1 - have significant differences of oxidative stress markers as compared to GSTM1 + / GSTT1 + genotype .
20674986	0	GSTT1	84,89	GSTM1	69,74	GSTT1	GSTM1	2952	2944	Gene	Gene	M1|appos|START_ENTITY M1|appos|END_ENTITY	Bipolar_disorder and polymorphisms of glutathione_S-transferases M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- .
20708344	0	GSTT1	75,80	GSTM1	68,73	GSTT1	GSTM1	2952	2944	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
21701824	0	GSTT1	108,113	GSTM1	93,98	GSTT1	GSTM1	2952	2944	Gene	Gene	M1|appos|START_ENTITY M1|appos|END_ENTITY	Age-related macular_degeneration and genetic polymorphisms of glutathione_S-transferases M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- .
22377702	0	GSTT1	0,5	GSTM1	106,111	GSTT1	GSTM1	2952	2944	Gene	Gene	genotype|nummod|START_ENTITY factor|nsubj|genotype factor|advcl|confer confer|nsubj|genotype genotype|nummod|END_ENTITY	GSTT1 null genotype is a risk factor for diabetic_retinopathy in Caucasians with type 2 diabetes , whereas GSTM1 null genotype might confer protection against retinopathy .
22539183	0	GSTT1	55,60	GSTM1	70,75	GSTT1	GSTM1	2952	2944	Gene	Gene	glutathione_S-transferase_T1|appos|START_ENTITY glutathione_S-transferase_T1|appos|END_ENTITY	Genetic polymorphisms of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- and M1 -LRB- GSTM1 -RRB- in selected populations of Afghanistan .
22652274	0	GSTT1	19,24	GSTM1	12,17	GSTT1	GSTM1	2952	2944	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|compound|END_ENTITY	The role of GSTM1 , GSTT1 , GSTP1 , and OGG1 polymorphisms in type_2_diabetes_mellitus risk : a case-control study in a Turkish population .
22788240	0	GSTT1	41,46	GSTM1	34,39	GSTT1	GSTM1	2952	2944	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|appos|END_ENTITY	Genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors is associated with adverse reactions to anti-tuberculosis drugs .
23570881	0	GSTT1	7,12	GSTM1	0,5	GSTT1	GSTM1	2952	2944	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|compound|END_ENTITY	GSTM1 , GSTT1 , GSTP1 , and GSTA1 genetic variants are not associated with coronary_artery_disease in Taiwan .
23873097	0	GSTT1	12,17	GSTM1	19,24	GSTT1	GSTM1	2952	2944	Gene	Gene	Association|nummod|START_ENTITY Association|nummod|END_ENTITY	Association GSTT1 , GSTM1 and GSTP1 -LRB- Ile105Val -RRB- genetic polymorphisms in mothers with risk of congenital_malformations in their children in Western Siberia : a case-control study .
24375038	0	GSTT1	58,63	GSTM1	99,104	GSTT1	GSTM1	2952	2944	Gene	Gene	glutathione_S-transferase_T1|appos|START_ENTITY glutathione_S-transferase_T1|appos|END_ENTITY	Is there any association of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- and glutathione_S-transferase M1 -LRB- GSTM1 -RRB- gene polymorphism with gastric_cancers ?
24532428	0	GSTT1	62,67	GSTM1	47,52	GSTT1	GSTM1	2952	2944	Gene	Gene	glutathione_S-transferase_M1|appos|START_ENTITY glutathione_S-transferase_M1|appos|END_ENTITY	Polymorphisms of glutathione_S-transferase_M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- in ovarian_cancer risk .
25432281	0	GSTT1	53,58	GSTM1	38,43	GSTT1	GSTM1	2952	2944	Gene	Gene	Glutathione-S-Transferase_M1|appos|START_ENTITY Glutathione-S-Transferase_M1|appos|END_ENTITY	Role of Glutathione-S-Transferase_M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- Genes in the Development and Progress of Chronic_Myeloid_Leukemia and in the Formation of Response to Imatinib Therapy .
25461363	0	GSTT1	62,67	GSTM1	47,52	GSTT1	GSTM1	2952	2944	Gene	Gene	glutathione_S-transferase_M1|appos|START_ENTITY glutathione_S-transferase_M1|appos|END_ENTITY	Polymorphisms of glutathione_S-transferase_M1 -LRB- GSTM1 -RRB- and T1 -LRB- GSTT1 -RRB- and endometriosis risk : a meta-analysis .
26125851	0	GSTT1	44,49	GSTM1	37,42	GSTT1	GSTM1	2952	2944	Gene	Gene	GSTP1|appos|START_ENTITY GSTP1|compound|END_ENTITY	Short Communication Polymorphisms in GSTM1 , GSTT1 , GSTP1 , and GSTM3 genes and breast_cancer risk in northeastern Mexico .
26811816	0	GSTT1	62,67	GSTM1	77,82	GSTT1	GSTM1	2952	2944	Gene	Gene	Glutathione_S-Transferase_T1|appos|START_ENTITY Glutathione_S-Transferase_T1|appos|END_ENTITY	Prevalence of Null Genotypes of Glutathione_S-Transferase_T1 -LRB- GSTT1 -RRB- and M1 -LRB- GSTM1 -RRB- in Seven Iranian Populations .
8001244	0	GSTT1	38,43	GSTM1	114,119	GSTT1	GSTM1	2952	2944	Gene	Gene	genotypes|compound|START_ENTITY genotypes|dep|interactions interactions|nmod|END_ENTITY	Theta class glutathione_S-transferase GSTT1 genotypes and susceptibility to cervical neoplasia : interactions with GSTM1 , CYP2D6 and smoking .
8625505	0	GSTT1	26,31	GSTM1	101,106	GSTT1	GSTM1	2952	2944	Gene	Gene	genotypes|compound|START_ENTITY genotypes|dep|studies studies|nmod|interactions interactions|nmod|END_ENTITY	Glutathione_S-transferase GSTT1 genotypes and susceptibility to cancer : studies of interactions with GSTM1 in lung , oral , gastric and colorectal_cancers .
9788723	0	GSTT1	102,107	GSTM1	84,89	GSTT1	GSTM1	2952	2944	Gene	Gene	glutathione_S-transferase_mu|appos|START_ENTITY glutathione_S-transferase_mu|appos|END_ENTITY	Prevalence of homozygosity for the deleted alleles of glutathione_S-transferase_mu -LRB- GSTM1 -RRB- and theta -LRB- GSTT1 -RRB- among distinct ethnic groups from Brazil : relevance to environmental_carcinogenesis ?
10666194	0	GSTT1	61,66	GSTP1	68,73	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Polymorphisms within glutathione_S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and risk of relapse in childhood B-cell precursor acute_lymphoblastic_leukemia : a case-control study .
15565566	0	GSTT1	65,70	GSTP1	72,77	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Genetic polymorphisms in glutathione-S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and survival after chemotherapy for invasive breast_carcinoma .
16047490	0	GSTT1	25,30	GSTP1	39,44	GSTT1	GSTP1	2952	2950	Gene	Gene	MnSOD|compound|START_ENTITY MnSOD|appos|END_ENTITY	Genetic polymorphisms of GSTT1 , GSTM1 , GSTP1 , MnSOD , and catalase in nonhereditary chronic_pancreatitis : evidence of xenobiotic stress and impaired antioxidant capacity .
20505681	0	GSTT1	72,77	GSTP1	79,84	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	The association of glutathione-S-transferase gene polymorphisms -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- with idiopathic_male_infertility .
21243008	0	GSTT1	53,58	GSTP1	60,65	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Glutathione_S-transferase gene polymorphisms -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and prostate_cancer : a case-control study in Tehran , Iran .
22154357	0	GSTT1	73,78	GSTP1	80,85	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Association of genetic polymorphism of glutathione_S-transferase -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- with bladder_cancer susceptibility .
22903474	0	GSTT1	48,53	GSTP1	55,60	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Glutathione_S-transferase polymorphisms -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and male_factor_infertility risk : a pooled analysis of studies .
23014993	0	GSTT1	67,72	GSTP1	74,79	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Study of the association between glutathione_S-transferase -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- polymorphisms with type_II_diabetes_mellitus in southern of Iran .
25532576	0	GSTT1	72,77	GSTP1	79,84	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Association of polymorphisms in glutathione_S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- with idiopathic azoospermia or oligospermia in Sichuan , China .
26252359	0	GSTT1	76,81	GSTP1	83,88	GSTT1	GSTP1	2952	2950	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Effects of genetic polymorphisms of glutathione_S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- on the risk of diabetic_nephropathy : a meta-analysis .
14681495	0	GSTT1	40,45	Glutathione_S_transferase_theta_1	0,33	GSTT1	Glutathione S transferase theta 1	2952	2952	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glutathione_S_transferase_theta_1 gene -LRB- GSTT1 -RRB- null genotype is associated with an increased risk for acquired aplastic_anemia in children .
18986377	0	GSTT1	56,61	LPL	75,78	GSTT1	LPL	2952	4023	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20708344	0	GSTT1	75,80	MLH1	88,92	GSTT1	MLH1	2952	4292	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
25249451	0	GSTT1	26,31	MLH1	20,24	GSTT1	MLH1	2952	4292	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association of DCC , MLH1 , GSTT1 , GSTM1 , and TP53 gene polymorphisms with colorectal_cancer in Kazakhstan .
20708344	0	GSTT1	75,80	MSH2	82,86	GSTT1	MSH2	2952	4436	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20373852	0	GSTT1	63,68	MTHFR	77,82	GSTT1	MTHFR	2952	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	GSTT1	63,68	MTRR	84,88	GSTT1	MTRR	2952	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20301895	0	GSTT1	82,87	MnSOD	94,99	GSTT1	MnSOD	2952	6648	Gene	Gene	CAT|compound|START_ENTITY GSTM1|dep|CAT GSTM1|dep|GPX1 GPX1|compound|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20445800	0	GSTT1	74,79	MnSOD	86,91	GSTT1	MnSOD	2952	6648	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
16906563	0	GSTT1	60,65	NAT1	48,52	GSTT1	NAT1	2952	9	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Risk of limb deficiency_defects associated with NAT1 , NAT2 , GSTT1 , GSTM1 , and NOS3 genetic variants , maternal smoking , and vitamin supplement intake .
16906563	0	GSTT1	60,65	NAT2	54,58	GSTT1	NAT2	2952	10	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Risk of limb deficiency_defects associated with NAT1 , NAT2 , GSTT1 , GSTM1 , and NOS3 genetic variants , maternal smoking , and vitamin supplement intake .
18986377	0	GSTT1	56,61	NAT2	69,73	GSTT1	NAT2	2952	10	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
19303722	0	GSTT1	28,33	NAT2	15,19	GSTT1	NAT2	2952	10	Gene	Gene	CYP2A6|appos|START_ENTITY CYP2A6|compound|END_ENTITY	Association of NAT2 , GSTM1 , GSTT1 , CYP2A6 , and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder_cancer in Central China .
20373852	0	GSTT1	63,68	NAT2	96,100	GSTT1	NAT2	2952	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
22788240	0	GSTT1	41,46	NAT2	28,32	GSTT1	NAT2	2952	10	Gene	Gene	CYP2E1|appos|START_ENTITY CYP2E1|compound|END_ENTITY	Genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors is associated with adverse reactions to anti-tuberculosis drugs .
16235982	0	GSTT1	0,5	NQO1	27,31	GSTT1	NQO1	2952	1728	Gene	Gene	deletions|compound|START_ENTITY deletions|appos|polymorphism polymorphism|compound|END_ENTITY	GSTT1 and GSTM1 deletions , NQO1 C609T polymorphism and risk of chronic_myelogenous_leukemia in Japanese .
18986377	0	GSTT1	56,61	NQO1	63,67	GSTT1	NQO1	2952	1728	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20373852	0	GSTT1	63,68	NQO1	90,94	GSTT1	NQO1	2952	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
18986377	0	GSTT1	56,61	PRSS1	80,85	GSTT1	PRSS1	2952	5644	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
16160620	0	GSTT1	33,38	PgP	40,43	GSTT1	PgP	2952	283871	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
20401725	0	GSTT1	41,46	TNFR2	24,29	GSTT1	TNFR2	2952	7133	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association analysis of TNFR2 , VDR , A2M , GSTT1 , GSTM1 , and ACE genes with rheumatoid_arthritis in South Asians and Caucasians of East Midlands in the United Kingdom .
20401725	0	GSTT1	41,46	VDR	31,34	GSTT1	VDR	2952	7421	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association analysis of TNFR2 , VDR , A2M , GSTT1 , GSTM1 , and ACE genes with rheumatoid_arthritis in South Asians and Caucasians of East Midlands in the United Kingdom .
20708344	0	GSTT1	75,80	XPD	63,66	GSTT1	XPD	2952	2068	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	GSTT1	75,80	XRCC3	56,61	GSTT1	XRCC3	2952	7517	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
16624155	0	GSTT1	43,48	glutathione_S-transferase	16,41	GSTT1	glutathione S-transferase	2952	373156	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	-LSB- The effects of glutathione_S-transferase -LRB- GSTT1 and GSTM1 -RRB- genes polymorphisms on treatment efficacy and prognosis of acute_myeloid_leukemia -RSB- .
23444902	0	GSTT1	71,76	glutathione_S-transferase	19,44	GSTT1	glutathione S-transferase	2952	373156	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	The association of glutathione_S-transferase gene mutations -LRB- including GSTT1 and GSTM1 -RRB- with the prognostic factors and relapse in acute_lymphoblastic_leukemia .
16874663	0	GSTT1	44,49	glutathione_S-transferase_T1	14,42	GSTT1	glutathione S-transferase T1	2952	2952	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- in human brain_tumours .
12019185	0	GSTZ1-1	79,86	glutathione_transferase_zeta	49,77	GSTZ1-1	glutathione transferase zeta	681913(Tax:10116)	681913(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization and activity of glutathione_transferase_zeta -LRB- GSTZ1-1 -RRB- in rat tissues .
18476723	0	GST_A1	47,53	Keap1	0,5	GST A1	Keap1	2938	9817	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Keap1 regulates the constitutive expression of GST_A1 during differentiation of Caco-2 cells .
22652643	0	GST_P1	0,6	LRRK2	40,45	GST P1	LRRK2	2950	120892	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	GST_P1 , a novel downstream regulator of LRRK2 , G2019S-induced neuronal cell death .
11556154	0	GST_T1	67,73	glutathione-S-transferase_T1	37,65	GST T1	glutathione-S-transferase T1	2952	2952	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the human erythrocytic glutathione-S-transferase_T1 -LRB- GST_T1 -RRB- by thimerosal .
11179824	0	GSTa1	82,87	glutathione_S-transferase	56,81	GSTa1	glutathione S-transferase	14857(Tax:10090)	54486(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Polymorphic electrophile response elements in the mouse glutathione_S-transferase GSTa1 gene that confer increased induction .
15595630	0	GSTs	80,84	erythropoietin	49,63	GSTs	erythropoietin	373156	2056	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of MDS patients with recombinant human erythropoietin and the role of GSTs .
8243334	0	GT1	43,46	c-fos	23,28	GT1	c-fos	2683	2353	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Autocrine induction of c-fos expression in GT1 neuronal cells by gonadotropin-releasing_hormone .
10677547	0	GT1	100,103	gonadotropin-releasing_hormone	56,86	GT1	gonadotropin-releasing hormone	2683	2796	Gene	Gene	cells|nummod|START_ENTITY secretion|nmod|cells secretion|amod|END_ENTITY	Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing_hormone secretion in GT1 cells .
9370297	0	GT334	31,36	EHOC-1	38,44	GT334	EHOC-1	54049	7109	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure of the human GT334 -LRB- EHOC-1 -RRB- gene mapping to 21q22 .3 .
9521869	0	GTF2I	54,59	Gtf2i	26,31	GTF2I	Gtf2i	2969	14886(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	A mouse single-copy gene , Gtf2i , the homolog of human GTF2I , that is duplicated in the Williams-Beuren_syndrome deletion region .
15016471	0	GTK	38,41	glutamine_transaminase_K	12,36	GTK	glutamine transaminase K	883	883	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of glutamine_transaminase_K -LRB- GTK -RRB- in sulfur and alpha-keto_acid metabolism in the brain , and in the possible bioactivation of neurotoxicants .
11455198	0	GTP-binding_protein	34,53	Go	55,57	GTP-binding protein	Go	280872(Tax:9913)	280872(Tax:9913)	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association of heterotrimeric GTP-binding_protein -LRB- Go -RRB- with microtubules .
8095554	0	GTP-binding_protein	86,105	Go_alpha	77,85	GTP-binding protein	Go alpha	59021(Tax:10090)	14681(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	D2-dopaminergic agonist quinpirole and 8-bromo-cAMP have opposite effects on Go_alpha GTP-binding_protein mRNA without changing D2 dopamine receptor mRNA levels in striatal neurones in primary culture .
2504724	0	GTP-binding_protein	43,62	p21	23,26	GTP-binding protein	p21	8843	1026	Gene	Gene	Phosphorylation|amod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of smg p21 , a ras p21-like GTP-binding_protein , by cyclic_AMP-dependent protein kinase in a cell-free system and in response to prostaglandin_E1 in intact human platelets .
2849942	0	GTP-binding_protein	85,104	p21	110,113	GTP-binding protein	p21	8843	644914	Gene	Gene	START_ENTITY|appos|smg smg|nummod|END_ENTITY	Phosphorylation by cyclic_AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding_protein -LRB- smg p21 -RRB- having the same putative effector domain as the ras gene products .
12726922	0	GTP-cyclohydrolase_I	84,104	nitric_oxide_synthase	119,140	GTP-cyclohydrolase I	nitric oxide synthase	2643	4843	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Hydrogen_peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase_I and increases nitric_oxide_synthase activity in vascular endothelial cells .
22798524	0	GTP_cyclohydrolase_1	14,34	NOS1	68,72	GTP cyclohydrolase 1	NOS1	2643	4842	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Cardiomyocyte GTP_cyclohydrolase_1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation .
20491893	0	GTP_cyclohydrolase_I	29,49	GCH1	51,55	GTP cyclohydrolase I	GCH1	2643	2643	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel missense mutation in GTP_cyclohydrolase_I -LRB- GCH1 -RRB- gene causes Dopa-responsive_dystonia in Chinese Han population .
15448133	0	GTP_cyclohydrolase_I	52,72	GFRP	76,80	GTP cyclohydrolase I	GFRP	2643	2644	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis of biopterin-induced inhibition of GTP_cyclohydrolase_I by GFRP , its feedback regulatory protein .
19286659	0	GTP_cyclohydrolase_I	0,20	GTP_cyclohydrolase_feedback_regulatory_protein	122,168	GTP cyclohydrolase I	GTP cyclohydrolase feedback regulatory protein	14528(Tax:10090)	320415(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|levels levels|appos|independent independent|nmod|expression expression|compound|END_ENTITY	GTP_cyclohydrolase_I expression , protein , and activity determine intracellular tetrahydrobiopterin levels , independent of GTP_cyclohydrolase_feedback_regulatory_protein expression .
19926872	0	GTP_cyclohydrolase_I	0,20	GTP_cyclohydrolase_feedback_regulatory_protein	58,104	GTP cyclohydrolase I	GTP cyclohydrolase feedback regulatory protein	2643	2644	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	GTP_cyclohydrolase_I phosphorylation and interaction with GTP_cyclohydrolase_feedback_regulatory_protein provide novel regulation of endothelial tetrahydrobiopterin and nitric_oxide .
17394463	0	GTP_cyclohydrolase_I	14,34	Nurr1	65,70	GTP cyclohydrolase I	Nurr1	14528(Tax:10090)	18227(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of GTP_cyclohydrolase_I expression by orphan receptor Nurr1 in cell culture and in vivo .
11284739	0	GTP_cyclohydrolase_I	0,20	THP-1	114,119	GTP cyclohydrolase I	THP-1	2643	2736	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	GTP_cyclohydrolase_I mRNA : novel splice variants in the slime mould Physarum_polycephalum and in human monocytes -LRB- THP-1 -RRB- indicate conservation of mRNA processing .
9351511	0	GTP_cyclohydrolase_I	98,118	interleukin_1beta	40,57	GTP cyclohydrolase I	interleukin 1beta	29244(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Differential effect of dexamethasone on interleukin_1beta - and cyclic_AMP-triggered expression of GTP_cyclohydrolase_I in rat renal mesangial cells .
7685343	1	GTP_cyclohydrolase_I	145,165	kit_ligand	213,223	GTP cyclohydrolase I	kit ligand	14528(Tax:10090)	17311(Tax:10090)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of GTP_cyclohydrolase_I and tryptophan 5-monooxygenase activity by the kit_ligand .
19286659	0	GTP_cyclohydrolase_feedback_regulatory_protein	122,168	GTP_cyclohydrolase_I	0,20	GTP cyclohydrolase feedback regulatory protein	GTP cyclohydrolase I	320415(Tax:10090)	14528(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY independent|nmod|expression levels|appos|independent END_ENTITY|nsubj|levels	GTP_cyclohydrolase_I expression , protein , and activity determine intracellular tetrahydrobiopterin levels , independent of GTP_cyclohydrolase_feedback_regulatory_protein expression .
19926872	0	GTP_cyclohydrolase_feedback_regulatory_protein	58,104	GTP_cyclohydrolase_I	0,20	GTP cyclohydrolase feedback regulatory protein	GTP cyclohydrolase I	2644	2643	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	GTP_cyclohydrolase_I phosphorylation and interaction with GTP_cyclohydrolase_feedback_regulatory_protein provide novel regulation of endothelial tetrahydrobiopterin and nitric_oxide .
20704716	0	GTPase_regulator_associated_with_the_focal_adhesion_kinase	0,58	GRAF	60,64	GTPase regulator associated with the focal adhesion kinase	GRAF	23092	23092	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	GTPase_regulator_associated_with_the_focal_adhesion_kinase -LRB- GRAF -RRB- transcript was down-regulated in patients with myeloid_malignancies .
20018861	0	GTSE-1	6,12	p21	23,26	GTSE-1	p21	51512	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Human GTSE-1 regulates p21 -LRB- CIP1/WAF1 -RRB- stability conferring resistance to paclitaxel treatment .
15735604	0	GUCA1A	80,86	GCAP1	68,73	GUCA1A	GCAP1	2978	2980	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Autosomal_dominant_cone_dystrophy caused by a novel mutation in the GCAP1 gene -LRB- GUCA1A -RRB- .
15953638	0	GUCA1A	21,27	guanylate_cyclase-activating_protein_1	38,76	GUCA1A	guanylate cyclase-activating protein 1	2978	2980	Gene	Gene	Mutation|nmod|START_ENTITY Mutation|amod|END_ENTITY	Mutation in the gene GUCA1A , encoding guanylate_cyclase-activating_protein_1 , causes cone , cone-rod , and macular_dystrophy .
10507726	0	GUCA1B	56,62	guanylate_cyclase_activator_1B	24,54	GUCA1B	guanylate cyclase activator 1B	2979	2979	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic analysis of the guanylate_cyclase_activator_1B -LRB- GUCA1B -RRB- gene in patients with autosomal_dominant_retinal_dystrophies .
18037771	0	GUCA2B	98,104	guanylate_cyclase_activator_2B	66,96	GUCA2B	guanylate cyclase activator 2B	2981	2981	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotype-based case-control study of the association between the guanylate_cyclase_activator_2B -LRB- GUCA2B , Uroguanylin -RRB- gene and essential hypertension .
12325031	0	GUCY2D	45,51	RETGC1	37,43	GUCY2D	RETGC1	3000	3000	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Evidence of a founder effect for the RETGC1 -LRB- GUCY2D -RRB- 2943DelG mutation in Leber_congenital_amaurosis pedigrees of Finnish origin .
11937021	0	GUK-holder	69,79	DLG	89,92	GUK-holder	DLG	53563(Tax:7227)	32083(Tax:7227)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder , a novel DLG binding protein .
11937021	0	GUK-holder	69,79	scribble	15,23	GUK-holder	scribble	53563(Tax:7227)	44448(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Recruitment Recruitment|nmod|END_ENTITY	Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder , a novel DLG binding protein .
10467707	0	GULO	41,45	L-gulono-gamma-lactone_oxidase	4,34	GULO	L-gulono-gamma-lactone oxidase	396759(Tax:9823)	396759(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The L-gulono-gamma-lactone_oxidase gene -LRB- GULO -RRB- which is a candidate for vitamin_C deficiency in pigs maps to chromosome 14 .
17398097	0	GULP	84,88	Arf6	14,18	GULP	Arf6	51454	382	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP .
8565635	0	GUSB	100,104	beta-glucuronidase	75,93	GUSB	beta-glucuronidase	2990	2990	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene -LRB- GUSB -RRB- to 7q11 .21 -- > q11 .22 and two pseudogenes to 5p13 and 5q13 .
11142398	0	GUT2	113,117	glycerol-3-phosphate_dehydrogenase	72,106	GUT2	glycerol-3-phosphate dehydrogenase	854651(Tax:4932)	854651(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Carbon source-dependent transcriptional regulation of the mitochondrial glycerol-3-phosphate_dehydrogenase gene , GUT2 , from Saccharomyces_cerevisiae .
1676389	0	GUT2	97,101	glycerol-3-phosphate_dehydrogenase	61,95	GUT2	glycerol-3-phosphate dehydrogenase	854651(Tax:4932)	854651(Tax:4932)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Cloning and characterisation of the Saccharomyces_cerevisiae glycerol-3-phosphate_dehydrogenase -LRB- GUT2 -RRB- promoter .
19908244	0	GW112	17,22	NF_kappaB	31,40	GW112	NF kappaB	10562	4790	Gene	Gene	Gene|compound|START_ENTITY Gene|nmod|END_ENTITY	Up regulation of GW112 Gene by NF_kappaB promotes an antiapoptotic property in gastric_cancer cells .
18345015	0	GW182	0,5	Argonaute	23,32	GW182	Argonaute	43808(Tax:7227)	36544(Tax:7227)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay .
18358695	0	GYS1	19,23	Glycogen_synthase	0,17	GYS1	Glycogen synthase	100054723(Tax:9796)	100054723(Tax:9796)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Glycogen_synthase -LRB- GYS1 -RRB- mutation causes a novel skeletal muscle glycogenosis .
24215078	0	GYS1	56,60	glycogen_synthase	37,54	GYS1	glycogen synthase	100054723(Tax:9796)	100054723(Tax:9796)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Evidence of positive selection for a glycogen_synthase -LRB- GYS1 -RRB- mutation in domestic_horse populations .
14764074	0	GYS1	70,74	skeletal_muscle_glycogen_synthase	30,63	GYS1	skeletal muscle glycogen synthase	2997	2997	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the human skeletal_muscle_glycogen_synthase gene -LRB- GYS1 -RRB- promoter .
7713495	0	GZMM	24,28	Met-ase	10,17	GZMM	Met-ase	3004	3004	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human Met-ase gene -LRB- GZMM -RRB- : structure , sequence , and close physical linkage to the serine protease gene cluster on 19p13 .3 .
26229572	0	G_Protein-Coupled_Estrogen_Receptor	0,35	GPER	37,41	G Protein-Coupled Estrogen Receptor	GPER	2852	2852	Gene	Gene	Agonist|compound|START_ENTITY Agonist|appos|END_ENTITY	G_Protein-Coupled_Estrogen_Receptor -LRB- GPER -RRB- Agonist Dual Binding Mode Analyses toward Understanding of its Activation Mechanism : A Comparative Homology Modeling Approach .
25271165	0	G_Protein_Signaling_Modulator-3	0,31	NLRP3	70,75	G Protein Signaling Modulator-3	NLRP3	106512(Tax:10090)	216799(Tax:10090)	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Activity Activity|nmod|END_ENTITY	G_Protein_Signaling_Modulator-3 Inhibits the Inflammasome Activity of NLRP3 .
15980433	0	G_alpha12	0,9	alphaSNAP	27,36	G alpha12	alphaSNAP	2768	8775	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	G_alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function .
11602570	0	G_alpha_11	35,45	PYK2	0,4	G alpha 11	PYK2	2767	2185	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	PYK2 as a mediator of endothelin-1 / G_alpha_11 signaling to GLUT4 glucose transporters .
10420881	0	G_alpha_13	63,73	A-kinase_anchoring_protein	8,34	G alpha 13	A-kinase anchoring protein	10672	11214	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	A novel A-kinase_anchoring_protein in the heart interacts with G_alpha_13 .
15879107	0	G_alpha_i2	53,63	TGF-beta	9,17	G alpha i2	TGF-beta	14678(Tax:10090)	21803(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Impaired TGF-beta responses in peripheral T cells of G_alpha_i2 - / - mice .
8825633	0	G_alpha_q	78,87	GNAQ	94,98	G alpha q	GNAQ	2776	2776	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning of human G_alpha_q cDNA and chromosomal localization of the G_alpha_q gene -LRB- GNAQ -RRB- and a processed pseudogene .
8732687	0	G_alpha_q	0,9	PTH-related_peptide	58,77	G alpha q	PTH-related peptide	2776	5744	Gene	Gene	receptors|dep|START_ENTITY receptors|compound|END_ENTITY	G_alpha_q family members couple parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide and calcitonin receptors to phospholipase C in COS-7 cells .
12704201	0	G_alpha_q	10,19	phosphatidylinositol_3-kinase	40,69	G alpha q	phosphatidylinositol 3-kinase	2776	5295	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Activated G_alpha_q inhibits p110 alpha phosphatidylinositol_3-kinase and Akt .
24726471	0	G_protein-coupled_estrogen_receptor_1	21,58	Akt	59,62	G protein-coupled estrogen receptor 1	Akt	76854(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Raloxifene activates G_protein-coupled_estrogen_receptor_1 / Akt signaling to protect dopamine neurons in 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine mice .
20445128	0	G_protein-coupled_estrogen_receptor_1	28,65	GPER	67,71	G protein-coupled estrogen receptor 1	GPER	171104(Tax:10116)	171104(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and signaling of G_protein-coupled_estrogen_receptor_1 -LRB- GPER -RRB- in rat sertoli cells .
26981789	0	G_protein-coupled_estrogen_receptor_1	23,60	GPER-1	62,68	G protein-coupled estrogen receptor 1	GPER-1	2852	2852	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The protective role of G_protein-coupled_estrogen_receptor_1 -LRB- GPER-1 -RRB- on methotrexate-induced nephrotoxicity in human renal epithelium cells .
20299453	0	G_protein-coupled_receptor	16,42	GPCR	44,48	G protein-coupled receptor	GPCR	151	151	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of a G_protein-coupled_receptor -LRB- GPCR -RRB- leads to attenuation of signaling by other GPCRs : experimental evidence for a spontaneous GPCR constitutive inactive form .
17043217	0	G_protein-coupled_receptor	22,48	erbB2	0,5	G protein-coupled receptor	erbB2	10663	2064	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	erbB2 is required for G_protein-coupled_receptor signaling in the heart .
18375760	0	G_protein-coupled_receptor	52,78	parathyroid_hormone	25,44	G protein-coupled receptor	parathyroid hormone	491678(Tax:9615)	403986(Tax:9615)	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Molecular recognition of parathyroid_hormone by its G_protein-coupled_receptor .
17308128	0	G_protein-coupled_receptor_30	0,29	G-1	138,141	G protein-coupled receptor 30	G-1	2852	5544	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian_cancer cells .
17379646	0	G_protein-coupled_receptor_30	42,71	GPR30	73,78	G protein-coupled receptor 30	GPR30	2852	2852	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of the novel estrogen receptor G_protein-coupled_receptor_30 -LRB- GPR30 -RRB- at the plasma membrane .
22521737	0	G_protein-coupled_receptor_30	106,135	IL-1_beta	24,33	G protein-coupled receptor 30	IL-1 beta	2852	3553	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Genistein regulates the IL-1_beta induced activation of MAPKs in human periodontal ligament cells through G_protein-coupled_receptor_30 .
20023170	0	G_protein-coupled_receptor_48	0,29	estrogen_receptor_alpha	42,65	G protein-coupled receptor 48	estrogen receptor alpha	107515(Tax:10090)	13982(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	G_protein-coupled_receptor_48 upregulates estrogen_receptor_alpha expression via cAMP/PKA signaling in the male reproductive tract .
15665093	0	G_protein-coupled_receptor_54	74,103	Kisspeptin	0,10	G protein-coupled receptor 54	Kisspeptin	114229(Tax:10090)	280287(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Kisspeptin directly stimulates gonadotropin-releasing_hormone release via G_protein-coupled_receptor_54 .
15665093	0	G_protein-coupled_receptor_54	74,103	gonadotropin-releasing_hormone	31,61	G protein-coupled receptor 54	gonadotropin-releasing hormone	114229(Tax:10090)	14714(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Kisspeptin directly stimulates gonadotropin-releasing_hormone release via G_protein-coupled_receptor_54 .
16389273	0	G_protein-coupled_receptor_78	50,79	GPR78	81,86	G protein-coupled receptor 78	GPR78	27201	27201	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association analysis of the chromosome 4p-located G_protein-coupled_receptor_78 -LRB- GPR78 -RRB- gene in bipolar_affective_disorder and schizophrenia .
23379999	0	G_protein-coupled_receptor_91	104,133	VEGF	35,39	G protein-coupled receptor 91	VEGF	408199(Tax:10116)	83785(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G_protein-coupled_receptor_91 .
12381737	0	G_protein-coupled_receptor_kinase-2	108,143	platelet-derived_growth_factor_receptor-beta	23,67	G protein-coupled receptor kinase-2	platelet-derived growth factor receptor-beta	156	5159	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of the platelet-derived_growth_factor_receptor-beta and epidermal_growth_factor_receptor by G_protein-coupled_receptor_kinase-2 .
15994317	0	G_protein-coupled_receptor_kinase-2	78,113	platelet-derived_growth_factor_receptor-beta	4,48	G protein-coupled receptor kinase-2	platelet-derived growth factor receptor-beta	156	5159	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The platelet-derived_growth_factor_receptor-beta phosphorylates and activates G_protein-coupled_receptor_kinase-2 .
10567420	0	G_protein-coupled_receptor_kinase_2	41,76	GRK2	78,82	G protein-coupled receptor kinase 2	GRK2	110355(Tax:10090)	110355(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Agonist-dependent phosphorylation of the G_protein-coupled_receptor_kinase_2 -LRB- GRK2 -RRB- by Src tyrosine kinase .
10574913	0	G_protein-coupled_receptor_kinase_2	23,58	GRK2	60,64	G protein-coupled receptor kinase 2	GRK2	156	156	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Feedback inhibition of G_protein-coupled_receptor_kinase_2 -LRB- GRK2 -RRB- activity by extracellular signal-regulated kinases .
10884381	0	G_protein-coupled_receptor_kinase_2	59,94	phosducin	19,28	G protein-coupled receptor kinase 2	phosducin	156	5132	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of phosducin and phosducin-like_protein by G_protein-coupled_receptor_kinase_2 .
9685424	0	G_protein-coupled_receptor_kinase_5	14,49	GRK5	51,55	G protein-coupled receptor kinase 5	GRK5	2869	2869	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of G_protein-coupled_receptor_kinase_5 -LRB- GRK5 -RRB- by actin .
11700307	0	G_protein-coupled_receptor_kinase_5	0,35	PSD-95	90,96	G protein-coupled receptor kinase 5	PSD-95	2869	1742	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|association association|nmod|END_ENTITY	G_protein-coupled_receptor_kinase_5 regulates beta 1-adrenergic receptor association with PSD-95 .
20443868	0	G_protein-coupled_receptor_kinase_5	84,119	VEGF	23,27	G protein-coupled receptor kinase 5	VEGF	2869	7422	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of VEGF signaling in human coronary artery endothelial cells by G_protein-coupled_receptor_kinase_5 .
19852948	0	G_protein-coupled_receptor_kinase_5	0,35	bcl-2	128,133	G protein-coupled receptor kinase 5	bcl-2	14773(Tax:10090)	12043(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	G_protein-coupled_receptor_kinase_5 , overexpressed in the alpha-synuclein up-regulation model of Parkinson 's _ disease , regulates bcl-2 expression .
22467873	0	G_protein-coupled_receptor_kinase_5	0,35	nucleophosmin	51,64	G protein-coupled receptor kinase 5	nucleophosmin	2869	4869	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	G_protein-coupled_receptor_kinase_5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like_kinase_1 inhibition .
20200162	0	G_protein-coupled_receptors	101,128	ERK5	82,86	G protein-coupled receptors	ERK5	227289(Tax:10090)	23939(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	G_alpha -LRB- q -RRB- acts as an adaptor protein in protein kinase C zeta -LRB- PKCzeta -RRB- - mediated ERK5 activation by G_protein-coupled_receptors -LRB- GPCR -RRB- .
8524786	0	G_protein_alpha_subunit	31,54	dGq_alpha-3	56,67	G protein alpha subunit	dGq alpha-3	36384(Tax:7227)	36384(Tax:7227)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of a Drosophila G_protein_alpha_subunit -LRB- dGq_alpha-3 -RRB- expressed in chemosensory cells and central neurons .
14586390	0	G_protein_beta3	98,113	GNB3	128,132	G protein beta3	GNB3	2784	2784	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Venous response to nitroglycerin is enhanced in young , healthy carriers of the 825T allele of the G_protein_beta3 subunit gene -LRB- GNB3 -RRB- .
14692527	0	G_protein_beta3	49,64	GNB3	71,75	G protein beta3	GNB3	2784	2784	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The CC genotype of the C825T polymorphism of the G_protein_beta3 gene -LRB- GNB3 -RRB- is associated with a high relapse rate in patients with chronic_lymphocytic_leukaemia .
12576843	0	G_protein_beta_3	41,57	GNB3	66,70	G protein beta 3	GNB3	2784	2784	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Sildenafil response is influenced by the G_protein_beta_3 subunit GNB3 C825T polymorphism : a pilot study .
11313907	0	G_protein_coupled_receptor	0,26	Src	49,52	G protein coupled receptor	Src	10663	6714	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|pathway pathway|compound|END_ENTITY	G_protein_coupled_receptor signaling through the Src and Stat3 pathway : role in proliferation and transformation .
11466257	0	G_protein_coupled_receptor-75	18,47	GPR75	49,54	G protein coupled receptor-75	GPR75	10936	10936	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of the G_protein_coupled_receptor-75 -LRB- GPR75 -RRB- in age_related_macular_degeneration .
10618718	0	Gab1	90,94	Crk	62,65	Gab1	Crk	2549	1398	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation .
10618718	0	Gab1	90,94	Crk	97,100	Gab1	Crk	2549	1398	Gene	Gene	mediated|nmod|START_ENTITY mediated|parataxis|signaling signaling|nsubj|END_ENTITY	Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation .
19350053	0	Gab1	47,51	Crk	0,3	Gab1	Crk	2549	1398	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration .
12629518	0	Gab1	0,4	ErbB2	80,85	Gab1	ErbB2	14388(Tax:10090)	13866(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2 .
26706435	0	Gab1	31,35	PECAM1	0,6	Gab1	PECAM1	14388(Tax:10090)	18613(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling .
17658473	0	Gab1	19,23	beta1_integrin	43,57	Gab1	beta1 integrin	2549	3688	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	The involvement of Gab1 and PI 3-kinase in beta1_integrin signaling in keratinocytes .
10551845	0	Gab1	36,40	epidermal_growth_factor_receptor	3,35	Gab1	epidermal growth factor receptor	2549	1956	Gene	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling END_ENTITY|parataxis|required	An epidermal_growth_factor_receptor / Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic_acid .
10455108	0	Gab1	14,18	erythropoietin	31,45	Gab1	erythropoietin	2549	2056	Gene	Gene	Engagement|nmod|START_ENTITY Engagement|nmod|signaling signaling|compound|END_ENTITY	Engagement of Gab1 and Gab2 in erythropoietin signaling .
19665053	0	Gab1	0,4	erythropoietin	30,44	Gab1	erythropoietin	2549	2056	Gene	Gene	transduces|nsubj|START_ENTITY transduces|dobj|signals signals|compound|END_ENTITY	Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells .
25041730	0	Gab1	27,31	huntingtin	7,17	Gab1	huntingtin	2549	3064	Gene	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth_factor_receptor_binding_protein_2 -LRB- Grb2 -RRB- .
17178724	0	Gab1	24,28	vascular_endothelial_growth_factor	38,72	Gab1	vascular endothelial growth factor	540085(Tax:9913)	281572(Tax:9913)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	The scaffolding adapter Gab1 mediates vascular_endothelial_growth_factor signaling and is required for endothelial cell migration and capillary formation .
21653832	0	Gab2	0,4	ARF1	27,31	Gab2	ARF1	14389(Tax:10090)	11840(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Gab2 , via PI-3K , regulates ARF1 in Fc __ RI-mediated granule translocation and mast cell degranulation .
12124177	0	Gab2	18,22	BCR/ABL	44,51	Gab2	BCR/ABL	14389(Tax:10090)	110279;11350	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role for Gab2 in transformation by BCR/ABL .
23401857	0	Gab2	0,4	RSK	24,27	Gab2	RSK	9846	6196	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility .
22859374	0	Gab2	16,20	mucin	31,36	Gab2	mucin	9846	100508689	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway .
18697750	0	Gab2	0,4	phosphoinositide_3-kinase	33,58	Gab2	phosphoinositide 3-kinase	9846	5293	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Gab2 is involved in differential phosphoinositide_3-kinase signaling by two splice forms of c-Kit .
9105679	0	Gabra6	41,47	GABAA_receptor_alpha_6	4,26	Gabra6	GABAA receptor alpha 6	14399(Tax:10090)	14399(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The GABAA_receptor_alpha_6 subunit gene -LRB- Gabra6 -RRB- is tightly linked to the alpha 1-gamma 2 subunit cluster on mouse chromosome 11 .
15142446	0	Gadd45	1,7	BRCA1	51,56	Gadd45	BRCA1	1647	672	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|arrest arrest|acl|induced induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Gadd45 mediated G2/M cell cycle arrest induced by BRCA1 -RSB- .
7478510	0	Gadd45	22,28	Gadd45	83,89	Gadd45	Gadd45	1647	1647	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
7478510	0	Gadd45	83,89	Gadd45	22,28	Gadd45	Gadd45	1647	1647	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
7478510	0	Gadd45	22,28	PCNA	112,116	Gadd45	PCNA	1647	5111	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
7478510	0	Gadd45	83,89	PCNA	112,116	Gadd45	PCNA	1647	5111	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
7478510	0	Gadd45	83,89	PCNA	34,38	Gadd45	PCNA	1647	5111	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|Gadd45 Gadd45|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
17428471	0	Gadd45a	0,7	JNK	100,103	Gadd45a	JNK	13197(Tax:10090)	26419(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Gadd45a , the gene induced by the mood stabilizer valproic_acid , regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells .
25845601	0	Gadd45a	0,7	TDG	43,46	Gadd45a	TDG	1647	6996	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Gadd45a promotes DNA demethylation through TDG .
26022109	0	Gadd45a	72,79	TGF-b1	46,52	Gadd45a	TGF-b1	1647	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
26022109	0	Gadd45a	72,79	TGF-b1	46,52	Gadd45a	TGF-b1	1647	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
16772293	0	Gadd45a	0,7	aurora-A	23,31	Gadd45a	aurora-A	13197(Tax:10090)	20878(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Gadd45a interacts with aurora-A and inhibits its kinase activity .
12833139	0	Gadd45alpha	8,19	p27	66,69	Gadd45alpha	p27	13197(Tax:10090)	12576(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of Gadd45alpha in the density-dependent G1 arrest induced by p27 -LRB- Kip1 -RRB- .
26698301	0	Gadd45b	21,28	Huwe1	0,5	Gadd45b	Huwe1	299626(Tax:10116)	501546(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells .
23948959	0	Gadd45b	0,7	p53	42,45	Gadd45b	p53	299626(Tax:10116)	301300(Tax:10116)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Gadd45b is transcriptionally activated by p53 via p38a-mediated phosphorylation during myocardial ischemic_injury .
11403721	0	Gadd45beta	93,103	MyD118	85,91	Gadd45beta	MyD118	17873(Tax:10090)	17873(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 -LRB- Gadd45beta -RRB- gene .
23751077	0	Gadd45g	0,7	p21	81,84	Gadd45g	p21	10912	644914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression .
23751077	0	Gadd45g	0,7	p38	63,66	Gadd45g	p38	10912	1432	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression .
11012671	0	Gadd45gamma	14,25	C/EBP	40,45	Gadd45gamma	C/EBP	10912	1050	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of Gadd45gamma expression by C/EBP .
18826392	0	Gads	36,40	GPVI	75,79	Gads	GPVI	17444(Tax:10090)	243816(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 .
10811803	0	Gads	21,25	Grb2	15,19	Gads	Grb2	9402	2885	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of Grb2 , Gads , and phospholipase_C-gamma_1 with phosphorylated LAT tyrosine residues .
12620234	0	Gads	45,49	SLP-76	89,95	Gads	SLP-76	9402	3937	Gene	Gene	domain|compound|START_ENTITY domain|nmod|peptide peptide|compound|END_ENTITY	Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide : a novel mode of peptide recognition .
16354835	0	Gads	48,52	SLP-76	25,31	Gads	SLP-76	17444(Tax:10090)	16822(Tax:10090)	Gene	Gene	site|compound|START_ENTITY upstream|nmod|site upstream|compound|END_ENTITY	A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function .
16479002	0	Gads	38,42	SLP-76	14,20	Gads	SLP-76	9402	3937	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells .
16479002	0	Gads	38,42	SLP-76	74,80	Gads	SLP-76	9402	3937	Gene	Gene	interaction|nmod|START_ENTITY Disruption|nmod|interaction inhibits|nsubj|Disruption inhibits|dobj|clustering clustering|nmod|END_ENTITY	Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells .
17823979	0	Gads	121,125	SLP-76	114,120	Gads	SLP-76	9402	3937	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76 / Gads interaction .
16139856	0	Gag	21,24	AP-2	62,66	Gag	AP-2	155030(Tax:11676)	7020	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2 .
19325895	0	Gag	26,29	Anx2	0,4	Gag	Anx2	155030(Tax:11676)	302	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Anx2 interacts with HIV-1 Gag at phosphatidylinositol -LRB- 4,5 -RRB- bisphosphate-containing lipid rafts and increases viral production in 293T cells .
14645565	0	Gag	48,51	BAF	34,37	Gag	BAF	155030(Tax:11676)	8815	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Barrier-to-autointegration_factor BAF binds p55 Gag and matrix and is a host component of human_immunodeficiency_virus_type_1 virions .
17182686	0	Gag	60,63	CD8	0,3	Gag	CD8	155030(Tax:11676)	925	Gene	Gene	regions|compound|START_ENTITY epitopes|nmod|regions recognition|nmod|epitopes recognition|compound|END_ENTITY	CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low_steady-state_viremia in human_immunodeficiency_virus_type_1-seropositive patients .
17548613	0	Gag	109,112	CD8	33,36	Gag	CD8	155030(Tax:11676)	925	Gene	Gene	epitope|compound|START_ENTITY specific|nmod|epitope +|dobj|specific +|nsubj|Availability Availability|nmod|END_ENTITY	Availability of a diversely avid CD8 + T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope .
18945768	0	Gag	117,120	CD8	91,94	Gag	CD8	155030(Tax:11676)	925	Gene	Gene	protein|compound|START_ENTITY epitope|nmod|protein epitope|nsubj|consequences consequences|nmod|escape escape|nmod|T-cell T-cell|compound|END_ENTITY	Functional consequences of human immunodeficiency virus escape from an HLA-B * 13-restricted CD8 + T-cell epitope in p1 Gag protein .
21887282	0	Gag	110,113	CD8	23,26	Gag	CD8	155030(Tax:11676)	925	Gene	Gene	Thais|compound|START_ENTITY region|nmod|Thais targets|dobj|region targets|nsubj|response response|nummod|END_ENTITY	A novel immunodominant CD8 + T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais .
15680412	0	Gag	174,177	Gag-Pol	30,37	Gag	Gag-Pol	155030(Tax:11676)	155348(Tax:11676)	Gene	Gene	expressing|dobj|START_ENTITY enhance|advcl|expressing enhance|nsubj|Clustered_epitopes Clustered_epitopes|nmod|vaccine vaccine|compound|END_ENTITY	Clustered_epitopes within the Gag-Pol fusion protein DNA vaccine enhance immune responses and protection against challenge with recombinant vaccinia viruses expressing HIV-1 Gag and Pol antigens .
10770790	0	Gag	55,58	Gag-pol	70,77	Gag	Gag-pol	155030(Tax:11676)	155348(Tax:11676)	Gene	Gene	Pr55|appos|START_ENTITY Pr55|appos|END_ENTITY	Comparison of human_immunodeficiency_virus_type_1 Pr55 -LRB- Gag -RRB- and Pr160 -LRB- Gag-pol -RRB- processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors .
14694138	0	Gag	124,127	Gag-pol	138,145	Gag	Gag-pol	155030(Tax:11676)	155348(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Incorporation of pol into human_immunodeficiency_virus_type_1 Gag virus-like particles occurs independently of the upstream Gag domain in Gag-pol .
14694138	0	Gag	62,65	Gag-pol	138,145	Gag	Gag-pol	155030(Tax:11676)	155348(Tax:11676)	Gene	Gene	particles|compound|START_ENTITY pol|nmod|particles Incorporation|nmod|pol occurs|nsubj|Incorporation occurs|nmod|domain domain|nmod|END_ENTITY	Incorporation of pol into human_immunodeficiency_virus_type_1 Gag virus-like particles occurs independently of the upstream Gag domain in Gag-pol .
18945768	0	Gag	117,120	HLA-B	71,76	Gag	HLA-B	155030(Tax:11676)	3106	Gene	Gene	protein|compound|START_ENTITY epitope|nmod|protein epitope|nsubj|consequences consequences|nmod|escape escape|nmod|T-cell T-cell|compound|END_ENTITY	Functional consequences of human immunodeficiency virus escape from an HLA-B * 13-restricted CD8 + T-cell epitope in p1 Gag protein .
15564502	0	Gag	55,58	Nedd4	8,13	Gag	Nedd4	1491923(Tax:11886)	4734	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Nedd4 and ubiquitination of Rous_sarcoma_virus Gag in budding of virus-like particles from cells .
16226779	0	Gag	43,46	SP1	29,32	Gag	SP1	155030(Tax:11676)	6667	Gene	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	The T12I mutation within the SP1 region of Gag restricts packaging of spliced viral RNA into human_immunodeficiency_virus_type_1 with mutated RNA packaging signals and mutated nucleocapsid sequence .
15908698	0	Gag	52,55	Tsg101	0,6	Gag	Tsg101	17276(Tax:10090)	22088(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding .
16275650	0	Gag	14,17	cyclophilin_A	44,57	Gag	cyclophilin A	155030(Tax:11676)	5478	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Altered HIV-1 Gag protein interactions with cyclophilin_A -LRB- CypA -RRB- on the acquisition of H219Q and H219P substitutions in the CypA binding loop .
17634229	0	Gag	44,47	p10	48,51	Gag	p10	1491923(Tax:11886)	6281	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Overlapping roles of the Rous_sarcoma_virus Gag p10 domain in nuclear export and virion core morphology .
21085616	0	Gag	4,7	p12	26,29	Gag	p12	17276(Tax:10090)	69745(Tax:10090)	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	The Gag cleavage product , p12 , is a functional constituent of the murine leukemia virus pre-integration complex .
25343245	0	Gag	28,31	p24	80,83	Gag	p24	155030(Tax:11676)	10959	Gene	Gene	Panel|compound|START_ENTITY Generation|nmod|Panel Generation|nmod|Detection Detection|compound|END_ENTITY	Generation of a Recombinant Gag Virus-Like-Particle Panel for the Evaluation of p24 Antigen Detection by Diagnostic HIV Tests .
8627263	0	Gag	122,125	p24	85,88	Gag	p24	155030(Tax:11676)	10959	Gene	Gene	assembly|compound|START_ENTITY essential|nmod|assembly essential|nsubj|interactions interactions|nmod|domain domain|nmod|antigen antigen|amod|END_ENTITY	Gag-Gag interactions in the C-terminal domain of human_immunodeficiency_virus_type_1 p24 capsid antigen are essential for Gag particle assembly .
15680412	0	Gag-Pol	30,37	Gag	174,177	Gag-Pol	Gag	155348(Tax:11676)	155030(Tax:11676)	Gene	Gene	vaccine|compound|START_ENTITY Clustered_epitopes|nmod|vaccine enhance|nsubj|Clustered_epitopes enhance|advcl|expressing expressing|dobj|END_ENTITY	Clustered_epitopes within the Gag-Pol fusion protein DNA vaccine enhance immune responses and protection against challenge with recombinant vaccinia viruses expressing HIV-1 Gag and Pol antigens .
23302874	0	Gag-Pol	71,78	gag	25,28	Gag-Pol	gag	155348(Tax:11676)	155030(Tax:11676)	Gene	Gene	dimerization|amod|START_ENTITY processing|nmod|dimerization END_ENTITY|acl|processing	Efavirenz enhances HIV-1 gag processing at the plasma membrane through Gag-Pol dimerization .
10770790	0	Gag-pol	70,77	Gag	55,58	Gag-pol	Gag	155348(Tax:11676)	155030(Tax:11676)	Gene	Gene	Pr55|appos|START_ENTITY Pr55|appos|END_ENTITY	Comparison of human_immunodeficiency_virus_type_1 Pr55 -LRB- Gag -RRB- and Pr160 -LRB- Gag-pol -RRB- processing intermediates that accumulate in primary and transformed cells treated with peptidic and nonpeptidic protease inhibitors .
14694138	0	Gag-pol	138,145	Gag	124,127	Gag-pol	Gag	155348(Tax:11676)	155030(Tax:11676)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Incorporation of pol into human_immunodeficiency_virus_type_1 Gag virus-like particles occurs independently of the upstream Gag domain in Gag-pol .
14694138	0	Gag-pol	138,145	Gag	62,65	Gag-pol	Gag	155348(Tax:11676)	155030(Tax:11676)	Gene	Gene	domain|nmod|START_ENTITY occurs|nmod|domain occurs|nsubj|Incorporation Incorporation|nmod|pol pol|nmod|particles particles|compound|END_ENTITY	Incorporation of pol into human_immunodeficiency_virus_type_1 Gag virus-like particles occurs independently of the upstream Gag domain in Gag-pol .
23244209	0	Gal-1	26,31	galectin-1	14,24	Gal-1	galectin-1	3956	3956	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	A decrease in galectin-1 -LRB- Gal-1 -RRB- levels correlates with an increase in anti-Gal-1 antibodies at the synovial level in patients with rheumatoid_arthritis .
25886742	0	Gal-9	6,11	TIM-3	0,5	Gal-9	TIM-3	3965	84868	Gene	Gene	interaction|compound|START_ENTITY induces|nsubj|interaction END_ENTITY|appos|induces	TIM-3 / Gal-9 interaction induces IFNy-dependent IDO1 expression in acute_myeloid_leukemia blast cells .
25886742	0	Gal-9	6,11	TIM-3	0,5	Gal-9	TIM-3	3965	84868	Gene	Gene	interaction|compound|START_ENTITY induces|nsubj|interaction END_ENTITY|appos|induces	TIM-3 / Gal-9 interaction induces IFNy-dependent IDO1 expression in acute_myeloid_leukemia blast cells .
26279267	0	Gal-9	8,13	TIM-3	2,7	Gal-9	TIM-3	3965	84868	Gene	Gene	Autocrine|nsubj|START_ENTITY END_ENTITY|parataxis|Autocrine	A TIM-3 / Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid_Leukemia Stem Cells and Leukemic_Progression .
23161469	0	Gal-9	97,102	Tim-3	91,96	Gal-9	Tim-3	3965	84868	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
25135732	0	Gal-9	33,38	Tim-3	27,32	Gal-9	Tim-3	3965	84868	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Up-regulated expression of Tim-3 / Gal-9 at maternal-fetal interface in pregnant woman with recurrent_spontaneous_abortion .
26342682	0	Gal-9	26,31	Tim-3	20,25	Gal-9	Tim-3	3965	84868	Gene	Gene	pathway|compound|START_ENTITY Upregulation|dep|pathway Upregulation|nmod|END_ENTITY	Upregulation of the Tim-3 / Gal-9 pathway and correlation with the development of preeclampsia .
18957435	0	Gal1p	68,73	galactokinase	36,49	Gal1p	galactokinase	852308(Tax:4932)	852308(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The effect of ligand binding on the galactokinase activity of yeast Gal1p and its ability to activate transcription .
12036446	0	Gal3ST-2	47,55	Gal_3-O-sulfotransferase-2	19,45	Gal3ST-2	Gal 3-O-sulfotransferase-2	64090	64090	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Down-regulation of Gal_3-O-sulfotransferase-2 -LRB- Gal3ST-2 -RRB- expression in human colonic_non-mucinous_adenocarcinoma .
11964151	0	Gal3p	0,5	Gal80p	60,66	Gal3p	Gal80p	851572(Tax:4932)	854954(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Gal3p and Gal1p interact with the transcriptional repressor Gal80p to form a complex of 1:1 stoichiometry .
20231363	0	Gal3st1	40,47	BORIS	134,139	Gal3st1	BORIS	53897(Tax:10090)	664799(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of a testis-specific form of Gal3st1 -LRB- CST -RRB- , a gene essential for spermatogenesis , is regulated by the CTCF paralogous gene BORIS .
20231363	0	Gal3st1	40,47	CST	49,52	Gal3st1	CST	53897(Tax:10090)	53897(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of a testis-specific form of Gal3st1 -LRB- CST -RRB- , a gene essential for spermatogenesis , is regulated by the CTCF paralogous gene BORIS .
12423206	0	Gal4p	86,91	TATA-binding_protein	4,24	Gal4p	TATA-binding protein	855828(Tax:4932)	856891(Tax:4932)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The TATA-binding_protein is not an essential target of the transcriptional activators Gal4p and Gcn4p in Saccharomyces_cerevisiae .
8658143	0	Gal4p	14,19	galactokinase	58,71	Gal4p	galactokinase	855828(Tax:4932)	852308(Tax:4932)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p .
11964151	0	Gal80p	60,66	Gal3p	0,5	Gal80p	Gal3p	854954(Tax:4932)	851572(Tax:4932)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Gal3p and Gal1p interact with the transcriptional repressor Gal80p to form a complex of 1:1 stoichiometry .
26544896	0	GalNAc-T14	0,10	HOXB9	53,58	GalNAc-T14	HOXB9	79623	3219	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung_adenocarcinoma .
24619076	0	GalNAc-T5	75,84	polypeptide_N-acetylgalactosaminyl_transferase-5	25,73	GalNAc-T5	polypeptide N-acetylgalactosaminyl transferase-5	11227	11227	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical significance of polypeptide_N-acetylgalactosaminyl_transferase-5 -LRB- GalNAc-T5 -RRB- expression in patients with gastric_cancer .
14610237	0	GalR1	16,21	Galanin	0,7	GalR1	Galanin	50577(Tax:10116)	29141(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY acts|nmod|receptors acts|compound|END_ENTITY	Galanin acts at GalR1 receptors in spinal antinociception : synergy with morphine and AP-5 .
15708483	0	GalR1	117,122	Galanin	7,14	GalR1	Galanin	14427(Tax:10090)	14419(Tax:10090)	Gene	Gene	density|amod|START_ENTITY strain|nmod|density END_ENTITY|dep|strain	-LSB- 125I -RSB- - Galanin binding in brain of wildtype , and galanin - and GalR1-knockout mice : _ strain and species differences in GalR1 density and distribution .
15934937	0	GalR1	0,5	galanin	55,62	GalR1	galanin	14427(Tax:10090)	14419(Tax:10090)	Gene	Gene	regulated|ccomp|START_ENTITY regulated|nmod|END_ENTITY	GalR1 , but not GalR2 or GalR3 , levels are regulated by galanin signaling in the locus coeruleus through a cyclic_AMP-dependent mechanism .
20121116	0	GalR1	56,61	galanin	12,19	GalR1	galanin	14427(Tax:10090)	14419(Tax:10090)	Gene	Gene	discriminate|nmod|START_ENTITY subtypes|amod|discriminate analogues|dobj|subtypes analogues|nsubj|END_ENTITY	Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery .
9271210	0	GalR1	66,71	galanin	72,79	GalR1	galanin	14427(Tax:10090)	14419(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Genomic organization and functional characterization of the mouse GalR1 galanin receptor .
15748163	0	GalR1	33,38	galanin_receptor-1	13,31	GalR1	galanin receptor-1	14427(Tax:10090)	14427(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of galanin_receptor-1 -LRB- GalR1 -RRB- expression in external granule cell layer of post-natal mouse cerebellum .
9578554	0	GalR2	54,59	galanin	60,67	GalR2	galanin	100760610	100760816	Gene	Gene	subtypes|compound|START_ENTITY subtypes|compound|END_ENTITY	Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes .
9832122	0	GalR2	10,15	galanin	16,23	GalR2	galanin	14428(Tax:10090)	14419(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The mouse GalR2 galanin receptor : genomic organization , cDNA cloning , and functional characterization .
12406501	0	GalR3	47,52	galanin_receptor_3	27,45	GalR3	galanin receptor 3	29235(Tax:10116)	29235(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Restricted distribution of galanin_receptor_3 -LRB- GalR3 -RRB- mRNA in the adult rat central nervous system .
26773505	0	GalT	43,47	Galactose-1_phosphate_uridylyltransferase	0,41	GalT	Galactose-1 phosphate uridylyltransferase	14430(Tax:10090)	14430(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Galactose-1_phosphate_uridylyltransferase -LRB- GalT -RRB- gene : A novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts .
12036446	0	Gal_3-O-sulfotransferase-2	19,45	Gal3ST-2	47,55	Gal 3-O-sulfotransferase-2	Gal3ST-2	64090	64090	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Down-regulation of Gal_3-O-sulfotransferase-2 -LRB- Gal3ST-2 -RRB- expression in human colonic_non-mucinous_adenocarcinoma .
26773505	0	Galactose-1_phosphate_uridylyltransferase	0,41	GalT	43,47	Galactose-1 phosphate uridylyltransferase	GalT	14430(Tax:10090)	14430(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Galactose-1_phosphate_uridylyltransferase -LRB- GalT -RRB- gene : A novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts .
26661062	0	Galanin	0,7	GLP-1	17,22	Galanin	GLP-1	14419(Tax:10090)	14526(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells .
14610237	0	Galanin	0,7	GalR1	16,21	Galanin	GalR1	29141(Tax:10116)	50577(Tax:10116)	Gene	Gene	acts|compound|START_ENTITY acts|nmod|receptors receptors|amod|END_ENTITY	Galanin acts at GalR1 receptors in spinal antinociception : synergy with morphine and AP-5 .
15708483	0	Galanin	7,14	GalR1	117,122	Galanin	GalR1	14419(Tax:10090)	14427(Tax:10090)	Gene	Gene	START_ENTITY|dep|strain strain|nmod|density density|amod|END_ENTITY	-LSB- 125I -RSB- - Galanin binding in brain of wildtype , and galanin - and GalR1-knockout mice : _ strain and species differences in GalR1 density and distribution .
7488089	0	Galanin	0,7	cholecystokinin	17,32	Galanin	cholecystokinin	14419(Tax:10090)	12424(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Galanin inhibits cholecystokinin secretion in STC-1 cells .
1702174	0	Galanin	0,7	growth_hormone-releasing_factor	34,65	Galanin	growth hormone-releasing factor	29141(Tax:10116)	29446(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Galanin stimulates immunoreactive growth_hormone-releasing_factor secretion from rat hypothalamic slices perifused in vitro .
1374016	0	Galanin	0,7	proinsulin	17,27	Galanin	proinsulin	14419(Tax:10090)	16334(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I -LRB- 7-37 -RRB- in mouse_insulinoma beta_TC-1 cells .
10971141	0	Galanin-like_peptide	0,20	GALP	22,26	Galanin-like peptide	GALP	64568(Tax:10116)	64568(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Galanin-like_peptide -LRB- GALP -RRB- mRNA expression is restricted to arcuate_nucleus of hypothalamus in adult male rat brain .
20689988	0	Galectin-1	0,10	BDNF	31,35	Galectin-1	BDNF	3956	24225(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia .
17015718	0	Galectin-1	0,10	CD43	27,31	Galectin-1	CD43	16852(Tax:10090)	20737(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|glycoforms glycoforms|compound|END_ENTITY	Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death .
17015718	0	Galectin-1	0,10	CD43	54,58	Galectin-1	CD43	16852(Tax:10090)	20737(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death .
24511119	0	Galectin-1	0,10	CXCR4	23,28	Galectin-1	CXCR4	3956	7852	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Galectin-1 upregulates CXCR4 to promote tumor progression and poor outcome in kidney_cancer .
23681112	0	Galectin-1	0,10	GAL-1	12,17	Galectin-1	GAL-1	3956	3956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Galectin-1 -LRB- GAL-1 -RRB- expression is a useful tool to differentiate between_small_cell_osteosarcoma and Ewing_sarcoma .
11709720	0	Galectin-1	0,10	H-Ras	27,32	Galectin-1	H-Ras	3956	3265	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation .
22345665	0	Galectin-1	0,10	IL-10	86,91	Galectin-1	IL-10	3956	3586	Gene	Gene	triggers|nsubj|START_ENTITY triggers|dobj|signature signature|nmod|cells cells|acl|defined defined|nmod|expression expression|compound|END_ENTITY	Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression .
18223683	0	Galectin-1	0,10	VEGFR-2	54,61	Galectin-1	VEGFR-2	3956	3791	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Galectin-1 , a novel ligand of neuropilin-1 , activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells .
24854997	0	Galectin-1	0,10	mucin	17,22	Galectin-1	mucin	3956	100508689	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Galectin-1 binds mucin in human trophoblast .
18223683	0	Galectin-1	0,10	neuropilin-1	30,42	Galectin-1	neuropilin-1	3956	8829	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Galectin-1 , a novel ligand of neuropilin-1 , activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells .
19171142	0	Galectin-1	0,10	tissue_plasminogen_activator	46,74	Galectin-1	tissue plasminogen activator	3956	100128998	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Galectin-1 is a novel functional receptor for tissue_plasminogen_activator in pancreatic_cancer .
26401586	0	Galectin-10	9,20	IL-22	35,40	Galectin-10	IL-22	1178	50616	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Elevated Galectin-10 Expression of IL-22 Producing T Cells in Atopic_Dermatitis Patients .
26448934	0	Galectin-1_and_90K	12,30	Mac-2BP	31,38	Galectin-1 and 90K	Mac-2BP	3956	3959	Gene	Gene	Circulating|dobj|START_ENTITY END_ENTITY|dep|Circulating	Circulating Galectin-1_and_90K / Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal_Cancer .
19330599	0	Galectin-2	0,10	LGALS2	12,18	Galectin-2	LGALS2	3957	3957	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Galectin-2 -LRB- LGALS2 -RRB- 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid_arthritis .
23065155	0	Galectin-3	0,10	CD45	20,24	Galectin-3	CD45	3958	5788	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Galectin-3 binds to CD45 on diffuse large B-cell_lymphoma cells to regulate susceptibility to cell death .
18413234	0	Galectin-3	0,10	N-Ras	52,57	Galectin-3	N-Ras	3958	4893	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras .
25315772	0	Galectin-3	15,25	NKp30	64,69	Galectin-3	NKp30	3958	259197	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Tumor-released Galectin-3 , a soluble inhibitory ligand of human NKp30 , plays an important role in tumor escape from NK cell attack .
15374939	0	Galectin-3	0,10	beta-catenin	39,51	Galectin-3	beta-catenin	3958	1499	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Galectin-3 , a novel binding partner of beta-catenin .
23160381	0	Galectin-3	0,10	p21	21,24	Galectin-3	p21	3958	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Galectin-3 regulates p21 stability in human prostate_cancer cells .
19276072	0	Galectin-8	0,10	ERK1/2	77,83	Galectin-8	ERK1/2	3964	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic_acid-mediated ERK1/2 activation supported by protein kinase A down-regulation .
24346075	0	Galectin-8	0,10	LFA-1	20,25	Galectin-8	LFA-1	3964	3683	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Galectin-8 binds to LFA-1 , blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients .
22438246	0	Galectin-9	0,10	CD4	52,55	Galectin-9	CD4	3965	920	Gene	Gene	renders|amod|START_ENTITY activated|nsubj|renders activated|xcomp|susceptible susceptible|nsubj|cells cells|compound|END_ENTITY	Galectin-9 binding to Tim-3 renders activated human CD4 + T cells less susceptible to HIV-1_infection .
22685601	0	Galectin-9	0,10	CD40	20,24	Galectin-9	CD40	16859(Tax:10090)	21939(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity .
20463811	0	Galectin-9	0,10	TIM-3	11,16	Galectin-9	TIM-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|interaction interaction|compound|END_ENTITY	Galectin-9 / TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response .
23936526	0	Galectin-9	15,25	TIM-3	26,31	Galectin-9	TIM-3	3965	84868	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|pathway pathway|compound|END_ENTITY	Involvement of Galectin-9 / TIM-3 pathway in the systemic inflammatory response in early-onset preeclampsia .
24477913	0	Galectin-9	0,10	TIM-3	29,34	Galectin-9	TIM-3	3965	84868	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing : an effect abrogated within the cystic_fibrosis_lung .
19017954	0	Galectin-9	0,10	Tim-3	21,26	Galectin-9	Tim-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|cells cells|amod|+ +|amod|END_ENTITY	Galectin-9 increases Tim-3 + dendritic cells and CD8 + T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions .
21187321	0	Galectin-9	0,10	Tim-3	61,66	Galectin-9	Tim-3	3965	84868	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	Galectin-9 regulates T helper cell function independently of Tim-3 .
22438246	0	Galectin-9	0,10	Tim-3	22,27	Galectin-9	Tim-3	3965	84868	Gene	Gene	renders|amod|START_ENTITY renders|amod|END_ENTITY	Galectin-9 binding to Tim-3 renders activated human CD4 + T cells less susceptible to HIV-1_infection .
22685601	0	Galectin-9	0,10	Tim-3	45,50	Galectin-9	Tim-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|CD40 CD40|acl|signaling signaling|nmod|mechanism mechanism|amod|independent independent|amod|END_ENTITY	Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity .
23585851	0	Galectin-9	0,10	Tim-3	120,125	Galectin-9	Tim-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	ameliorates|nsubj|START_ENTITY ameliorates|advcl|inducing inducing|nmod|END_ENTITY	Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3 .
25578313	0	Galectin-9	4,14	Tim-3	15,20	Galectin-9	Tim-3	3965	84868	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|END_ENTITY	The Galectin-9 / Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy .
26789128	0	Galectin-9	107,117	Tim-3	0,5	Galectin-9	Tim-3	3965	84868	Gene	Gene	Pathway|compound|START_ENTITY Trophoblast|nmod|Pathway Upregulated|nmod|Trophoblast Upregulated|nsubjpass|END_ENTITY	Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway .
22027828	0	Galectin-9	0,10	histone_deacetylase_3	78,99	Galectin-9	histone deacetylase 3	3965	8841	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Galectin-9 protein expression in endothelial cells is positively regulated by histone_deacetylase_3 .
19570914	0	Galpha	46,52	Pins	26,30	Galpha	Pins	36384(Tax:7227)	53569(Tax:7227)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Drosophila GoLoco-protein Pins is a target of Galpha -LRB- o -RRB- - mediated G protein-coupled receptor signaling .
12509430	0	Galpha	49,55	Ric-8A	10,16	Galpha	Ric-8A	8802	60626	Gene	Gene	factor|compound|START_ENTITY factor|nsubj|END_ENTITY	Mammalian Ric-8A -LRB- synembryn -RRB- is a heterotrimeric Galpha protein guanine_nucleotide exchange factor .
17098744	0	Galpha12	0,8	COX-2	32,37	Galpha12	COX-2	14673(Tax:10090)	19225(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|induction induction|compound|END_ENTITY	Galpha12 specifically regulates COX-2 induction by sphingosine_1-phosphate .
15525651	0	Galpha12	0,8	PP2A	33,37	Galpha12	PP2A	2768	5524	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Galpha12 directly interacts with PP2A : evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated_protein , _ tau .
15525651	0	Galpha12	0,8	PP2A	72,76	Galpha12	PP2A	2768	5524	Gene	Gene	interacts|nsubj|START_ENTITY interacts|parataxis|phosphatase phosphatase|nsubj|evidence evidence|nmod|END_ENTITY	Galpha12 directly interacts with PP2A : evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated_protein , _ tau .
17303700	0	Galpha12	22,30	PP2A	131,135	Galpha12	PP2A	2768	5524	Gene	Gene	necessary|nmod|START_ENTITY Domains|amod|necessary Domains|parataxis|subunit subunit|nmod|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
17303700	0	Galpha12	22,30	PP2A	82,86	Galpha12	PP2A	2768	5524	Gene	Gene	necessary|nmod|START_ENTITY Domains|amod|necessary Domains|appos|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
17303700	0	Galpha12	92,100	PP2A	131,135	Galpha12	PP2A	2768	5524	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
17303700	0	Galpha12	92,100	PP2A	82,86	Galpha12	PP2A	2768	5524	Gene	Gene	subunit|nsubj|START_ENTITY Domains|parataxis|subunit Domains|appos|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
15254210	0	Galpha12	108,116	US28	57,61	Galpha12	US28	2768	3077536(Tax:10359)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Human_cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth_muscle_cell migration through Galpha12 .
8663428	0	Galpha12	0,8	c-Jun_NH2-terminal_kinase	20,45	Galpha12	c-Jun NH2-terminal kinase	2768	5599	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Galpha12 stimulates c-Jun_NH2-terminal_kinase through the small G proteins Ras and Rac .
9641915	0	Galpha12	45,53	p115_RhoGEF	0,11	Galpha12	p115 RhoGEF	2768	9138;9181	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	p115_RhoGEF , a GTPase activating protein for Galpha12 and Galpha13 .
16354679	0	Galpha12	109,117	platelet-derived_growth_factor_receptor_alpha	19,64	Galpha12	platelet-derived growth factor receptor alpha	2768	5156	Gene	Gene	mutant|nmod|START_ENTITY END_ENTITY|nmod|mutant	Transactivation of platelet-derived_growth_factor_receptor_alpha by the GTPase-deficient activated mutant of Galpha12 .
19940064	0	Galpha13	51,59	CCK	0,3	Galpha13	CCK	14674(Tax:10090)	12424(Tax:10090)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini .
16601072	0	Galpha13	39,47	Estrogen_receptor_alpha	0,23	Galpha13	Estrogen receptor alpha	10672	2099	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Estrogen_receptor_alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway .
15339924	0	Galpha13	0,8	Hax-1	73,78	Galpha13	Hax-1	14674(Tax:10090)	23897(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1 .
12135322	0	Galpha13	0,8	JNK	48,51	Galpha13	JNK	10672	5599	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Galpha13 induces preproET-1 gene expression via JNK .
18940608	0	Galpha13	39,47	PDZRhoGEF	71,80	Galpha13	PDZRhoGEF	10672	9826;9181	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF .
15258251	0	Galpha13	50,58	p115RhoGEF	77,87	Galpha13	p115RhoGEF	10672	9138;9181	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated_RhoGEF .
12135322	0	Galpha13	0,8	preproET-1	17,27	Galpha13	preproET-1	10672	1906	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Galpha13 induces preproET-1 gene expression via JNK .
14551213	0	Galpha16	22,30	STAT3	42,47	Galpha16	STAT3	2769	6774	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK - _ and_ERK-dependent mechanism .
17575083	0	Galphai2	13,21	Ghrelin	0,7	Galphai2	Ghrelin	81664(Tax:10116)	59301(Tax:10116)	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Ghrelin uses Galphai2 and activates voltage-dependent K + channels to attenuate glucose-induced Ca2 + signaling and insulin release in islet beta-cells : novel signal transduction of ghrelin .
19225179	0	Galphao	56,63	CA3	141,144	Galphao	CA3	14681(Tax:10090)	12350(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A_adrenergic_receptor inhibition of mouse hippocampal CA3 epileptiform_activity .
10196137	0	Galphao	40,47	Purkinje_cell_protein-2	53,76	Galphao	Purkinje cell protein-2	14681(Tax:10090)	18545(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of heterotrimeric G protein Galphao with Purkinje_cell_protein-2 .
19225179	0	Galphao	56,63	alpha2A_adrenergic_receptor	81,108	Galphao	alpha2A adrenergic receptor	14681(Tax:10090)	11551(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A_adrenergic_receptor inhibition of mouse hippocampal CA3 epileptiform_activity .
17720980	0	Galphaq	33,40	GNAQ	42,46	Galphaq	GNAQ	2776	2776	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A functional polymorphism of the Galphaq -LRB- GNAQ -RRB- gene is associated with accelerated mortality in African-American heart_failure .
15471870	0	Galphaq	45,52	GRK2	24,28	Galphaq	GRK2	2776	156	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Characterization of the GRK2 binding site of Galphaq .
20399743	0	Galphaq	44,51	GSK-3beta	14,23	Galphaq	GSK-3beta	2776	2932	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of GSK-3beta and beta-Catenin by Galphaq in HEK293T cells .
11278452	0	Galphaq	40,47	Rho	53,56	Galphaq	Rho	2776	6010	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Physical and functional interactions of Galphaq with Rho and its exchange factors .
17606614	0	Galphaq	0,7	p63RhoGEF	27,36	Galphaq	p63RhoGEF	2776	115557;9181	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl_homology-associated pleckstrin homology domain .
20590159	0	Galphaq	56,63	thromboxane_A2_receptor	90,113	Galphaq	thromboxane A2 receptor	2776	6915	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane_A2_receptor provides evidence of constitutive activity .
12676897	0	Gamma-D_crystallin	0,18	CRYGD	25,30	Gamma-D crystallin	CRYGD	1421	1421	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gamma-D_crystallin gene -LRB- CRYGD -RRB- mutation causes autosomal_dominant_congenital_cerulean_cataracts .
11872161	0	Gamma-adaptin	0,13	Rabaptin-5	38,48	Gamma-adaptin	Rabaptin-5	164	9135	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain .
7841659	0	Gamma-glutamyl_transferase	0,26	GGT	28,31	Gamma-glutamyl transferase	GGT	116568(Tax:10116)	116568(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Gamma-glutamyl_transferase -LRB- GGT -RRB- activity and biochemical characterization of rat visceral yolk-sac during gestation with or without trypan_blue exposure .
24037855	0	Gankyrin	0,8	STAT3	73,78	Gankyrin	STAT3	5716	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Gankyrin promotes tumor growth and metastasis through activation of IL-6 / STAT3 signaling in human cholangiocarcinoma .
26975632	0	Gankyrin	0,8	mTORC1	19,25	Gankyrin	mTORC1	5716	382056(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal_cancer .
18455509	0	Gap-43	15,21	MAP-2	73,78	Gap-43	MAP-2	29423(Tax:10116)	25595(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Gap-43 -LRB- neuromodulin -RRB- with microtubule-associated protein MAP-2 in neuronal cells .
17612558	0	Gar1p	72,77	Cbf5p	109,114	Gar1p	Cbf5p	856489(Tax:4932)	850872(Tax:4932)	Gene	Gene	START_ENTITY|acl|mediating mediating|nmod|END_ENTITY	The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p .
2108904	0	Gart	36,40	adenosine3	24,34	Gart	adenosine3	33986(Tax:7227)	33986(Tax:7227)	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Genetic analysis of the adenosine3 -LRB- Gart -RRB- region of the second chromosome of Drosophila_melanogaster .
21820049	0	Gas1	0,4	Cdo	21,24	Gas1	Cdo	14451(Tax:10090)	57810(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Gas1 cooperates with Cdo and promotes myogenic differentiation via activation of p38MAPK .
15070677	0	Gas1	0,4	VE-cadherin	19,30	Gas1	VE-cadherin	2619	1003	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Gas1 is induced by VE-cadherin and vascular_endothelial_growth_factor and inhibits endothelial cell apoptosis .
25804736	0	Gas1	12,16	WT1	0,3	Gas1	WT1	14451(Tax:10090)	22431(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals .
11290560	0	Gas6	0,4	Axl	52,55	Gas6	Axl	2621	558	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis .
15380678	0	Gas6	0,4	Axl	59,62	Gas6	Axl	58935(Tax:10116)	308444(Tax:10116)	Gene	Gene	apoptosis|amod|START_ENTITY apoptosis|dep|role role|nmod|kinase kinase|compound|END_ENTITY	Gas6 inhibits apoptosis in vascular smooth muscle : role of Axl kinase and Akt .
15605394	0	Gas6	0,4	Axl	75,78	Gas6	Axl	2621	558	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|lines lines|acl|expressing expressing|dobj|receptor receptor|compound|END_ENTITY	Gas6 induces proliferation_in_prostate_carcinoma cell lines expressing the Axl receptor .
15733062	0	Gas6	0,4	Axl	15,18	Gas6	Axl	2621	558	Gene	Gene	receptors|nsubj|START_ENTITY receptors|ccomp|enhance enhance|nsubj|END_ENTITY	Gas6 receptors Axl , Sky and Mer enhance platelet activation and regulate thrombotic responses .
15958209	0	Gas6	11,15	Axl	41,44	Gas6	Axl	2621	558	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|ubiquitination ubiquitination|compound|END_ENTITY	Effects of Gas6 and hydrogen_peroxide in Axl ubiquitination and downregulation .
16227584	0	Gas6	74,78	Axl	8,11	Gas6	Axl	14456(Tax:10090)	26362(Tax:10090)	Gene	Gene	generated|nmod|START_ENTITY generated|nsubjpass|END_ENTITY	Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum .
16285961	0	Gas6	23,27	Axl	56,59	Gas6	Axl	58935(Tax:10116)	308444(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein END_ENTITY|nsubj|Expression	Expression and role of Gas6 protein and of its receptor Axl in hepatic regeneration from oval cells in the rat .
17064312	0	Gas6	0,4	Axl	56,59	Gas6	Axl	2621	558	Gene	Gene	ligands|nsubj|START_ENTITY ligands|nmod|subfamily subfamily|compound|END_ENTITY	Gas6 and protein S. Vitamin_K-dependent ligands for the Axl receptor tyrosine kinase subfamily .
19541935	0	Gas6	90,94	Axl	25,28	Gas6	Axl	2621	558	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple_sclerosis_lesions .
20088931	0	Gas6	0,4	Axl	58,61	Gas6	Axl	2621	558	Gene	Gene	complexed|nsubjpass|START_ENTITY complexed|nmod|END_ENTITY	Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood .
20546121	0	Gas6	21,25	Axl	37,40	Gas6	Axl	2621	558	Gene	Gene	role|nmod|START_ENTITY Potentiating|dobj|role _|advcl|Potentiating _|nsubj|END_ENTITY	Potentiating role of Gas6 and Tyro3 , Axl and Mer _ -LRB- TAM -RRB- _ receptors in human and murine platelet activation and thrombus stabilization .
21501828	0	Gas6	26,30	Axl	110,113	Gas6	Axl	2621	558	Gene	Gene	phosphatidylserine|compound|START_ENTITY kinase|nsubj|phosphatidylserine kinase|dobj|END_ENTITY	The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry .
7867073	0	Gas6	55,59	Axl	88,91	Gas6	Axl	2621	558	Gene	Gene	S|appos|START_ENTITY ligands|nsubj|S ligands|nmod|family family|compound|END_ENTITY	The anticoagulation factor protein S and its relative , Gas6 , are ligands for the Tyro_3 / Axl family of receptor tyrosine kinases .
26414399	0	Gas6	0,4	FoxO-1	61,67	Gas6	FoxO-1	14456(Tax:10090)	56458(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Gas6 regulates thrombin-induced expression of VCAM-1 through FoxO-1 in endothelial cells .
26552404	0	Gas6	56,60	Growth_Arrest-Specific_Protein_6	22,54	Gas6	Growth Arrest-Specific Protein 6	14456(Tax:10090)	14456(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Protective Effects of Growth_Arrest-Specific_Protein_6 -LRB- Gas6 -RRB- on Sepsis-Induced Acute_Kidney_Injury .
22907951	0	Gas6	31,35	Growth_arrest-specific_gene_6	0,29	Gas6	Growth arrest-specific gene 6	2621	2621	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Growth_arrest-specific_gene_6 -LRB- Gas6 -RRB- levels are elevated in patients with chronic_renal_failure .
26585956	0	Gas6	43,47	Prostaglandin_E_synthase	0,24	Gas6	Prostaglandin E synthase	14456(Tax:10090)	64292(Tax:10090)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Prostaglandin_E_synthase is upregulated by Gas6 during cancer-induced venous_thrombosis .
26414399	0	Gas6	0,4	VCAM-1	46,52	Gas6	VCAM-1	14456(Tax:10090)	22329(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Gas6 regulates thrombin-induced expression of VCAM-1 through FoxO-1 in endothelial cells .
21959217	0	Gas6	30,34	growth_arrest-specific_6	4,28	Gas6	growth arrest-specific 6	2621	2621	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	The growth_arrest-specific_6 -LRB- Gas6 -RRB- gene polymorphism c. 834 +7 G > A is associated with type 2 diabetes .
25915719	0	Gas6	50,54	growth_arrest-specific_6	24,48	Gas6	growth arrest-specific 6	2621	2621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the growth_arrest-specific_6 -LRB- Gas6 -RRB- gene polymorphism c. 834 ___ + ___ 7G > A and preeclampsia .
25915719	0	Gas6	50,54	growth_arrest-specific_6	24,48	Gas6	growth arrest-specific 6	2621	2621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the growth_arrest-specific_6 -LRB- Gas6 -RRB- gene polymorphism c. 834 ___ + ___ 7G > A and preeclampsia .
24512357	0	Gas6	56,60	growth_arrest-specific_protein_6	22,54	Gas6	growth arrest-specific protein 6	2621	2621	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Association of plasma growth_arrest-specific_protein_6 -LRB- Gas6 -RRB- concentrations with albuminuria in patients with type 2 diabetes .
20150425	0	Gas7	0,4	N-WASP	20,26	Gas7	N-WASP	85246(Tax:10116)	682507(Tax:10116)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons .
23376640	0	Gastrin	0,7	Akt	108,111	Gastrin	Akt	2520	207	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Gastrin acting on the cholecystokinin2_receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K / Akt pathway in human gastric_cancer cells .
8060296	0	Gastrin	0,7	CCK-A	80,85	Gastrin	CCK-A	2520	886	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Gastrin stimulates growth of human colon_cancer cells via a receptor other than CCK-A or CCK-B .
12612900	0	Gastrin	0,7	CCK2_receptor	80,93	Gastrin	CCK2 receptor	2520	887	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Gastrin induces proliferation in Barrett 's _ metaplasia through activation of the CCK2_receptor .
20932834	0	Gastrin	0,7	CCK2_receptor	77,90	Gastrin	CCK2 receptor	2520	887	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|cells cells|nmod|END_ENTITY	Gastrin increases its own synthesis in gastrointestinal_cancer cells via the CCK2_receptor .
8824290	0	Gastrin	0,7	Grb2	101,105	Gastrin	Grb2	2520	2885	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
17332476	0	Gastrin	0,7	TFF2	22,26	Gastrin	TFF2	14459(Tax:10090)	21785(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|promoter promoter|compound|END_ENTITY	Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways .
7883024	0	Gastrin	0,7	bombesin	37,45	Gastrin	bombesin	2520	2922	Gene	Gene	START_ENTITY|acl|releasing releasing|dobj|sites sites|amod|END_ENTITY	Gastrin releasing peptide-preferring bombesin binding sites in human lung .
9950815	0	Gastrin	0,7	c-fos	16,21	Gastrin	c-fos	25320(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	Gastrin induces c-fos gene transcription via multiple signaling pathways .
21995960	0	Gastrin	0,7	clusterin	53,62	Gastrin	clusterin	25320(Tax:10116)	24854(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats .
12239223	0	Gastrin	0,7	cyclooxygenase-2	19,35	Gastrin	cyclooxygenase-2	25320(Tax:10116)	29527(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways .
12388195	0	Gastrin	0,7	cyclooxygenase-2	51,67	Gastrin	cyclooxygenase-2	25320(Tax:10116)	29527(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|upregulation upregulation|amod|END_ENTITY	Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats .
12891702	0	Gastrin	0,7	cyclooxygenase-2	39,55	Gastrin	cyclooxygenase-2	14459(Tax:10090)	19225(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Gastrin and EGF synergistically induce cyclooxygenase-2 expression in Swiss_3T3 fibroblasts that express the CCK2 receptor .
15655524	0	Gastrin	0,7	cyclooxygenase-2	76,92	Gastrin	cyclooxygenase-2	2520	5743	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|growth growth|nmod|induction induction|amod|END_ENTITY	Gastrin promotes human colon_cancer cell growth via CCK-2_receptor-mediated cyclooxygenase-2 induction and prostaglandin_E2 production .
23376640	0	Gastrin	0,7	cyclooxygenase-2	56,72	Gastrin	cyclooxygenase-2	2520	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Gastrin acting on the cholecystokinin2_receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K / Akt pathway in human gastric_cancer cells .
9619831	0	Gastrin	0,7	eIF4E_binding_protein_1	35,58	Gastrin	eIF4E binding protein 1	2520	1978	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Gastrin induces phosphorylation of eIF4E_binding_protein_1 and translation initiation of ornithine_decarboxylase mRNA .
3518119	0	Gastrin	1,8	gastrin	44,51	Gastrin	gastrin	2520	2520	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nsubj|cells	-LSB- Gastrin cells and the basal level of serum gastrin in patients with insulin-dependent_diabetes_mellitus -RSB- .
9869605	0	Gastrin	0,7	heparin-binding_epidermal_growth_factor-like_growth_factor	16,74	Gastrin	heparin-binding epidermal growth factor-like growth factor	25320(Tax:10116)	25433(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Gastrin induces heparin-binding_epidermal_growth_factor-like_growth_factor in rat gastric epithelial cells transfected with gastrin_receptor .
8074225	0	Gastrin	0,7	histidine_decarboxylase	18,41	Gastrin	histidine decarboxylase	25320(Tax:10116)	24443(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Gastrin regulates histidine_decarboxylase activity and mRNA abundance in rat oxyntic mucosa .
9142914	0	Gastrin	0,7	histidine_decarboxylase	28,51	Gastrin	histidine decarboxylase	2520	3067	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|promoter promoter|compound|END_ENTITY	Gastrin regulates the human histidine_decarboxylase promoter through an AP-1-dependent mechanism .
9341140	0	Gastrin	0,7	histidine_decarboxylase	63,86	Gastrin	histidine decarboxylase	2520	3067	Gene	Gene	START_ENTITY|dep|regulate regulate|dobj|promoter promoter|compound|END_ENTITY	Gastrin and phorbol_12-myristate_13-acetate regulate the human histidine_decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric_cancer cells .
8824290	0	Gastrin	0,7	insulin_receptor_substrate_1	47,75	Gastrin	insulin receptor substrate 1	2520	3667	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
18719002	0	Gastrin	0,7	mcl-1	18,23	Gastrin	mcl-1	2520	4170	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Gastrin increases mcl-1 expression in type I gastric_carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2_receptor .
12740336	0	Gastrin	0,7	nuclear_factor_kappaB	18,39	Gastrin	nuclear factor kappaB	2520	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Gastrin activates nuclear_factor_kappaB -LRB- NFkappaB -RRB- through a protein kinase C dependent pathway involving NFkappaB inducing kinase , inhibitor kappaB -LRB- IkappaB -RRB- kinase , and tumour_necrosis_factor_receptor_associated_factor_6 -LRB- TRAF6 -RRB- in MKN-28 cells transfected with gastrin_receptor .
9619831	0	Gastrin	0,7	ornithine_decarboxylase	89,112	Gastrin	ornithine decarboxylase	2520	4953	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|mRNA mRNA|amod|END_ENTITY	Gastrin induces phosphorylation of eIF4E_binding_protein_1 and translation initiation of ornithine_decarboxylase mRNA .
17349623	0	Gastrin-releasing_peptide	0,25	Akt	36,39	Gastrin-releasing peptide	Akt	2922	207	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Gastrin-releasing_peptide activates Akt through the epidermal_growth_factor_receptor pathway and abrogates the effect of gefitinib .
3390695	0	Gastrin-releasing_peptide	0,25	GRP	27,30	Gastrin-releasing peptide	GRP	171101(Tax:10116)	171101(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Gastrin-releasing_peptide -LRB- GRP -RRB- immunoreactivity in the rat retina : a radioimmunoassay , immunohistochemical and chromatographic study .
15955628	0	Gastrin-releasing_peptide	0,25	c-Fos	34,39	Gastrin-releasing peptide	c-Fos	2922	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Gastrin-releasing_peptide induces c-Fos in the hamster suprachiasmatic nucleus .
15967120	0	Gastrin-releasing_peptide_receptor	0,34	epidermal_growth_factor_receptor	62,94	Gastrin-releasing peptide receptor	epidermal growth factor receptor	2925	1956	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Gastrin-releasing_peptide_receptor mediates activation of the epidermal_growth_factor_receptor in lung_cancer cells .
16963640	0	GatA	141,145	GatB	28,32	GatA	GatB	55278	5188	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	NMR structure of the enzyme GatB of the galactitol-specific phosphoenolpyruvate-dependent phosphotransferase system and its interaction with GatA .
16963640	0	GatB	28,32	GatA	141,145	GatB	GatA	5188	55278	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	NMR structure of the enzyme GatB of the galactitol-specific phosphoenolpyruvate-dependent phosphotransferase system and its interaction with GatA .
21464046	0	Gata1	17,22	Nkx2-5	0,6	Gata1	Nkx2-5	2623	1482	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis .
20351175	0	Gata1	48,53	p45	64,67	Gata1	p45	14460(Tax:10090)	18022(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis .
25848090	0	Gata2	46,51	Setd8	30,35	Gata2	Setd8	2624	387893	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation .
23310955	0	Gata3	41,46	CD4	54,57	Gata3	CD4	2625	920	Gene	Gene	START_ENTITY|nmod|T-cell T-cell|compound|END_ENTITY	Thpok-independent repression of Runx3 by Gata3 during CD4 + T-cell differentiation in the thymus .
23220102	0	Gata3	0,5	Fgf10	55,60	Gata3	Fgf10	14462(Tax:10090)	14165(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Gata3 directly regulates early inner ear expression of Fgf10 .
25917456	0	Gata3	0,5	Gcm2	22,26	Gata3	Gcm2	2625	9247	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Gata3 cooperates with Gcm2 and MafB to activate parathyroid_hormone gene expression by interacting with SP1 .
19112489	0	Gata3	0,5	beta-catenin	25,37	Gata3	beta-catenin	2625	1499	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction .
23836893	0	Gata4	52,57	Atonal_homolog_8	25,41	Gata4	Atonal homolog 8	14463(Tax:10090)	71093(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The transcription factor Atonal_homolog_8 regulates Gata4 and Friend of Gata-2 during vertebrate development .
15987774	0	Gata4	0,5	BMP4	54,58	Gata4	BMP4	14463(Tax:10090)	12159(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY downstream|nsubj|expression downstream|nmod|END_ENTITY	Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element .
14673170	0	Gata4	0,5	Dmrt1	37,42	Gata4	Dmrt1	2626	1761	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Gata4 regulates testis expression of Dmrt1 .
25024137	0	Gata6	0,5	aspartoacylase	16,30	Gata6	aspartoacylase	14465(Tax:10090)	11484(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival .
15680482	0	Gax	59,62	growth_arrest_specific_homeobox	26,57	Gax	growth arrest specific homeobox	4223	4223	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II suppresses growth_arrest_specific_homeobox -LRB- Gax -RRB- expression via redox-sensitive mitogen-activated protein kinase -LRB- MAPK -RRB- .
12947763	0	Gb3	78,81	Gb5	89,92	Gb3	Gb5	53947	10681	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- Synthesis of aminoethyl_glycosides of the carbohydrate chains of glycolipids Gb3 , Gb4 i Gb5 -RSB- .
11179369	0	Gb3	70,73	Tumor_necrosis_factor_alpha	0,27	Gb3	Tumor necrosis factor alpha	53947	7124	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha increases human cerebral endothelial cell Gb3 and sensitivity to Shiga toxin .
12947763	0	Gb5	89,92	Gb3	78,81	Gb5	Gb3	10681	53947	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Synthesis of aminoethyl_glycosides of the carbohydrate chains of glycolipids Gb3 , Gb4 i Gb5 -RSB- .
21750037	0	Gbb	32,35	BMP	20,23	Gbb	BMP	37778(Tax:7227)	37778(Tax:7227)	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction .
18755269	0	GbetaL	0,6	NF-kappaB	34,43	GbetaL	NF-kappaB	64223	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase .
20460648	0	Gbetagamma	0,10	GSK3	21,25	Gbetagamma	GSK3	35881(Tax:7227)	31248(Tax:7227)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity .
7823961	0	Gbp	53,56	Interferon_regulatory_factor_1	0,30	Gbp	Interferon regulatory factor 1	16854(Tax:10090)	16362(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Interferon_regulatory_factor_1 is required for mouse Gbp gene activation by gamma interferon .
8601031	0	Gbx-2	46,51	Stra7	39,44	Gbx-2	Stra7	14472(Tax:10090)	14472(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence and expression pattern of the Stra7 -LRB- Gbx-2 -RRB- homeobox-containing gene induced by retinoic_acid in P19 embryonal_carcinoma cells .
10518499	0	Gbx2	18,22	FGF8	0,4	Gbx2	FGF8	14472(Tax:10090)	14179(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate .
10330495	0	Gbx2	30,34	Otx2	24,28	Gbx2	Otx2	395950(Tax:9031)	395191(Tax:9031)	Gene	Gene	Fgf8|dep|START_ENTITY Fgf8|compound|END_ENTITY	Comparative analysis of Otx2 , Gbx2 , Pax2 , Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain .
10490024	0	Gbx2	11,15	Otx2	33,37	Gbx2	Otx2	14472(Tax:10090)	18424(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer .
11850185	0	Gbx2	0,4	Otx2	20,24	Gbx2	Otx2	399181(Tax:8355)	399342(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Gbx2 interacts with Otx2 and patterns the anterior-posterior axis during gastrulation in Xenopus .
22566684	0	Gbx2	0,4	Otx2	24,28	Gbx2	Otx2	14472(Tax:10090)	18424(Tax:10090)	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|expression expression|amod|END_ENTITY	Gbx2 directly restricts Otx2 expression to forebrain and midbrain , competing with class III POU factors .
11160333	0	Gc-globulin	64,75	C5a	131,134	Gc-globulin	C5a	2638	728	Gene	Gene	protein|appos|START_ENTITY the|nmod|protein the|dep|role role|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	Elastase controls the binding of the vitamin_D-binding protein -LRB- Gc-globulin -RRB- to neutrophils : a potential role in the regulation of C5a co-chemotactic activity .
15356163	0	Gc-globulin	82,93	C5a	137,140	Gc-globulin	C5a	2638	728	Gene	Gene	protein|appos|START_ENTITY necessary|nmod|protein necessary|xcomp|function function|nmod|cofactor cofactor|nmod|END_ENTITY	Platelet-derived thrombospondin-1 is necessary for the vitamin_D-binding protein -LRB- Gc-globulin -RRB- to function as a chemotactic cofactor for C5a .
18538666	0	Gc-globulin	110,121	C5a	5,8	Gc-globulin	C5a	2638	728	Gene	Gene	effect|nmod|START_ENTITY mortality|dep|effect associated|nmod|mortality associated|nsubjpass|levels levels|amod|END_ENTITY	High C5a levels are associated with increased mortality in sepsis patients -- no enhancing effect by actin-free Gc-globulin .
3392213	0	Gc-globulin	0,11	C5a	88,91	Gc-globulin	C5a	2638	728	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Gc-globulin -LRB- vitamin_D-binding protein -RRB- enhances the neutrophil chemotactic activity of C5a and C5a des Arg .
7594552	0	Gc-globulin	25,36	C5a	69,72	Gc-globulin	C5a	2638	728	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Co-chemotactic effect of Gc-globulin -LRB- vitamin_D binding protein -RRB- for C5a .
9179298	0	Gc2	57,60	vitamin_D-binding_protein	30,55	Gc2	vitamin D-binding protein	83733	2638	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Bacterial expression of human vitamin_D-binding_protein -LRB- Gc2 -RRB- in functional form .
7616106	0	Gc_globulin	11,22	C5a	54,57	Gc globulin	C5a	2638	728	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Gc_globulin -LRB- vitamin_D binding protein -RRB- to C5a or C5a des Arg is not necessary for co-chemotactic activity .
10330157	0	Gcd10p	57,63	GCD14p	0,6	Gcd10p	GCD14p	855663(Tax:4932)	853317(Tax:4932)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	GCD14p , a repressor of GCN4 translation , cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces_cerevisiae .
24973045	0	Gck	18,21	RARa	46,50	Gck	RARa	24385(Tax:10116)	24705(Tax:10116)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	A RARE of hepatic Gck promoter interacts with RARa , HNF4a and COUP-TFII that affect retinoic_acid - and insulin-induced Gck expression .
21558372	0	Gcm1	19,23	p45NF-E2	0,8	Gcm1	p45NF-E2	14531(Tax:10090)	18022(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation , placental vascularization and embryonic growth .
25917456	0	Gcm2	22,26	Gata3	0,5	Gcm2	Gata3	9247	2625	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Gata3 cooperates with Gcm2 and MafB to activate parathyroid_hormone gene expression by interacting with SP1 .
21713993	0	Gcm2	20,24	MafB	0,4	Gcm2	MafB	107889(Tax:10090)	16658(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MafB interacts with Gcm2 and regulates parathyroid_hormone expression and parathyroid development .
21239490	0	Gcn1	0,4	GCN2	79,83	Gcn1	GCN2	10985	440275	Gene	Gene	START_ENTITY|dep|implications implications|nmod|activation activation|nmod|END_ENTITY	Gcn1 and actin binding to Yih1 : implications for activation of the eIF2 kinase GCN2 .
25437641	0	Gcn1	0,4	Gcn2	109,113	Gcn1	Gcn2	852680(Tax:4932)	851877(Tax:4932)	Gene	Gene	contacts|amod|START_ENTITY kinase|nsubj|contacts kinase|dobj|END_ENTITY	Gcn1 contacts the small ribosomal protein Rps10 , which is required for full activation of the protein kinase Gcn2 .
26176233	0	Gcn2	4,8	Cdc28	67,72	Gcn2	Cdc28	851877(Tax:4932)	852457(Tax:4932)	Gene	Gene	Regulator|nsubj|START_ENTITY Regulator|nmod|END_ENTITY	The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast .
25437641	0	Gcn2	109,113	Gcn1	0,4	Gcn2	Gcn1	851877(Tax:4932)	852680(Tax:4932)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|contacts contacts|amod|END_ENTITY	Gcn1 contacts the small ribosomal protein Rps10 , which is required for full activation of the protein kinase Gcn2 .
11350978	0	Gcn2	0,4	Gcn4	14,18	Gcn2	Gcn4	851877(Tax:4932)	856709(Tax:4932)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation .
10567567	0	Gcn2	26,30	Hsp90	0,5	Gcn2	Hsp90	851877(Tax:4932)	855836(Tax:4932)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Hsp90 binds and regulates Gcn2 , the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 -LSB- corrected -RSB- .
8934531	0	Gcn4	63,67	ECA39	0,5	Gcn4	ECA39	856709(Tax:4932)	586	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	ECA39 is regulated by c-Myc in human and by a Jun/Fos homolog , Gcn4 , in yeast .
11350978	0	Gcn4	14,18	Gcn2	0,4	Gcn4	Gcn2	856709(Tax:4932)	851877(Tax:4932)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Gcn2 mediates Gcn4 activation in response to glucose stimulation or UV radiation not via GCN4 translation .
19525417	0	Gcn4p	48,53	ADE3	26,30	Gcn4p	ADE3	856709(Tax:4932)	853118(Tax:4932)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|END_ENTITY	Cooperative regulation of ADE3 transcription by Gcn4p and Bas1p in Saccharomyces_cerevisiae .
22904310	0	Gcn5	0,4	IL-9	36,40	Gcn5	IL-9	2648	3578	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells .
25071153	0	Gcn5	0,4	PPARy	23,28	Gcn5	PPARy	2648	5468	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Gcn5 and PCAF regulate PPARy and Prdm16 expression to facilitate brown adipogenesis .
24850134	0	Gcr1	40,44	PHO92	18,23	Gcr1	PHO92	856030(Tax:4932)	851980(Tax:4932)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	The expression of PHO92 is regulated by Gcr1 , and Pho92 is involved in glucose metabolism in Saccharomyces_cerevisiae .
15975906	0	Gcs1p	9,14	Arl1p	32,37	Gcs1p	Arl1p	851372(Tax:4932)	852462(Tax:4932)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments .
19297409	0	Gdf11	54,59	Foxg1	0,5	Gdf11	Foxg1	14561(Tax:10090)	15228(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11 .
17085896	0	Gdf5	67,71	growth_differentiation_factor_5	34,65	Gdf5	growth differentiation factor 5	14563(Tax:10090)	14563(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of mutation in the growth_differentiation_factor_5 -LRB- Gdf5 -RRB- gene in NC-brp/brp mice .
21144620	0	Gdnf	54,58	dopamine_transporter	9,29	Gdnf	dopamine transporter	14573(Tax:10090)	13162(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Enhanced dopamine_transporter activity in middle-aged Gdnf heterozygous mice .
21813735	0	Gea2p	85,90	Trs65p	0,6	Gea2p	Trs65p	856691(Tax:4932)	853076(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Trs65p , a subunit of the Ypt1p GEF TRAPPII , interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic .
24575369	0	Gelatinase_B	0,12	MMP-9	14,19	Gelatinase B	MMP-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gelatinase_B -LRB- MMP-9 -RRB- gene silencing does not affect murine preadipocyte differentiation .
14673159	0	Gelatinase_B	144,156	Pax6	22,26	Gelatinase B	Pax6	17395(Tax:10090)	18508(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nmod|Expression	Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase_B .
26598132	0	Gelsolin	0,8	LamR	24,28	Gelsolin	LamR	2934	3921	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Gelsolin interacts with LamR , hnRNP_U , nestin , Arp3 and b-tubulin in human melanoma cells as revealed by immunoprecipitation and mass spectrometry .
21801713	0	Gelsolin	0,8	p53	63,66	Gelsolin	p53	2934	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells .
16086184	0	Gem_interacting_protein	4,27	GMIP	29,33	Gem interacting protein	GMIP	51291	51291	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The Gem_interacting_protein -LRB- GMIP -RRB- gene is associated with major depressive_disorder .
18675250	0	Gemin4	100,106	SMN	76,79	Gemin4	SMN	50628	6606	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification and characterisation of a nuclear localisation signal in the SMN associated protein , Gemin4 .
11522829	0	Gemin4	46,52	galectin-1	15,25	Gemin4	galectin-1	50628	3956	Gene	Gene	Association|nmod|START_ENTITY Association|acl|END_ENTITY	Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein .
19656945	0	Geminin	0,7	Cdt1	19,23	Geminin	Cdt1	399373(Tax:8355)	398024(Tax:8355)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes .
26760771	0	Gene_33	0,7	Mig6	8,12	Gene 33	Mig6	54206	54206	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	Gene_33 / Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells .
23475391	0	Geranylgeranyltransferase_I	0,27	HIF-1a	38,44	Geranylgeranyltransferase I	HIF-1a	5229	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Geranylgeranyltransferase_I regulates HIF-1a promoting glioblastoma cell migration and invasion .
26769970	0	Germ_Cell_Nuclear_Factor	0,24	Oct4	42,46	Germ Cell Nuclear Factor	Oct4	2649	5460	Gene	Gene	Represses|nsubj|START_ENTITY Represses|dobj|Expression Expression|compound|END_ENTITY	Germ_Cell_Nuclear_Factor -LRB- GCNF -RRB- Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem -LRB- hES -RRB- Cells .
15345195	0	Gerp	76,80	TRIM-8	69,75	Gerp	TRIM-8	81603	81603	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization and cytokine-mediated inducibility of the human TRIM-8 / Gerp gene .
16949565	0	Get-1	46,51	Grhl3	52,57	Get-1	Grhl3	230824(Tax:10090)	57822	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	The Grainyhead-like epithelial transactivator Get-1 / Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4 .
17596540	0	Gfi-1	21,26	CXCR4	71,76	Gfi-1	CXCR4	2672	7852	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells .
17596540	0	Gfi-1	21,26	G-CSF	38,43	Gfi-1	G-CSF	2672	1440	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells .
20453161	0	Gfi-1	32,37	Id2	14,17	Gfi-1	Id2	14581(Tax:10090)	15902(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development .
25051963	0	Gfi-1	0,5	Id2	67,70	Gfi-1	Id2	14581(Tax:10090)	15902(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|repression repression|amod|END_ENTITY	Gfi-1 regulates the erythroid transcription factor network through Id2 repression in murine hematopoietic_progenitor_cells .
24018353	0	Gfi-1	0,5	SOCS1	42,47	Gfi-1	SOCS1	2672	8651	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Gfi-1 is the transcriptional repressor of SOCS1 in acute_myeloid_leukemia cells .
19188499	0	Gfi-1	19,24	TGF-beta	39,47	Gfi-1	TGF-beta	14581(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103 + inducible regulatory T cells .
22552881	0	Gfi-1	0,5	eosinophil_major_basic_protein	33,63	Gfi-1	eosinophil major basic protein	2672	5553	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Gfi-1 inhibits the expression of eosinophil_major_basic_protein -LRB- MBP -RRB- during G-CSF-induced neutrophilic differentiation .
19164764	0	Gfi-1	0,5	p15INK4B	32,40	Gfi-1	p15INK4B	2672	1030	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1 .
18034420	0	Gfi1	53,57	CD4	68,71	Gfi1	CD4	2672	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential impact of the transcriptional repressor Gfi1 on mature CD4 + and CD8 + T lymphocyte function .
26749286	0	Gfi1	0,4	CD4	104,107	Gfi1	CD4	14581(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|nmod|cells cells|compound|END_ENTITY	Gfi1 , a transcriptional repressor , inhibits the induction of the T helper type 1 programme in activated CD4 T cells .
20203268	0	Gfi1	25,29	G-CSF	40,45	Gfi1	G-CSF	14581(Tax:10090)	12985(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 .
16230531	0	Gfi1	0,4	Math1	29,34	Gfi1	Math1	14581(Tax:10090)	11921(Tax:10090)	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation .
20203268	0	Gfi1	25,29	RasGRP1	109,116	Gfi1	RasGRP1	14581(Tax:10090)	19419(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 .
15252036	0	Gfi1	135,139	growth_factor_independence_1	105,133	Gfi1	growth factor independence 1	14581(Tax:10090)	14581(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gfi1 : green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth_factor_independence_1 -LRB- Gfi1 -RRB- gene during lymphocyte development .
22865857	0	Gfi1	102,106	interleukin-7_receptor	35,57	Gfi1	interleukin-7 receptor	14581(Tax:10090)	16197(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	CD8 lineage-specific regulation of interleukin-7_receptor expression by the transcriptional repressor Gfi1 .
19278956	0	Gfi1	0,4	miR-21	15,21	Gfi1	miR-21	2672	406991	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Gfi1 regulates miR-21 and miR-196b to control myelopoiesis .
22658447	0	Ghrelin	0,7	Bax	18,21	Ghrelin	Bax	59301(Tax:10116)	24887(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Ghrelin regulates Bax and PCNA but not Bcl-2 expressions following scrotal hyperthermia in the rat .
23921150	0	Ghrelin	0,7	ERK	57,60	Ghrelin	ERK	58991(Tax:10090)	26413(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway .
22809535	0	Ghrelin	0,7	ERK1/2	86,92	Ghrelin	ERK1/2	59301(Tax:10116)	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Ghrelin induces cardiac lineage differentiation of human embryonic stem cells through ERK1/2 pathway .
21843570	0	Ghrelin	0,7	Fos	27,30	Ghrelin	Fos	58991(Tax:10090)	14281(Tax:10090)	Gene	Gene	agonists|nsubj|START_ENTITY agonists|nmod|expression expression|compound|END_ENTITY	Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice .
19361568	0	Ghrelin	0,7	GHS-R	18,23	Ghrelin	GHS-R	59301(Tax:10116)	100136603(Tax:8022)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Ghrelin receptor -LRB- GHS-R -RRB- - like receptor and its genomic organisation in rainbow_trout , Oncorhynchus_mykiss .
26279396	0	Ghrelin	0,7	GLP-1	18,23	Ghrelin	GLP-1	58991(Tax:10090)	14526(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Ghrelin regulates GLP-1 production through mTOR signaling in L cells .
17575083	0	Ghrelin	0,7	Galphai2	13,21	Ghrelin	Galphai2	59301(Tax:10116)	81664(Tax:10116)	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Ghrelin uses Galphai2 and activates voltage-dependent K + channels to attenuate glucose-induced Ca2 + signaling and insulin release in islet beta-cells : novel signal transduction of ghrelin .
24385298	0	Ghrelin	14,21	Ghrelin	83,90	Ghrelin	Ghrelin	442996(Tax:9940)	442996(Tax:9940)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|expression expression|compound|END_ENTITY	Expression of Ghrelin in gastrointestinal tract and the effect of early weaning on Ghrelin expression in lambs .
24385298	0	Ghrelin	83,90	Ghrelin	14,21	Ghrelin	Ghrelin	442996(Tax:9940)	442996(Tax:9940)	Gene	Gene	expression|compound|START_ENTITY Expression|nmod|expression Expression|nmod|END_ENTITY	Expression of Ghrelin in gastrointestinal tract and the effect of early weaning on Ghrelin expression in lambs .
18058910	0	Ghrelin	0,7	Pax4	29,33	Ghrelin	Pax4	58991(Tax:10090)	18506(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum .
19160422	0	Ghrelin	0,7	Runx2	84,89	Ghrelin	Runx2	58991(Tax:10090)	12393(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	Ghrelin inhibits early osteogenic differentiation of C3H10T1/2 cells by suppressing Runx2 expression and enhancing PPARgamma and C/EBPalpha expression .
17543279	0	Ghrelin	0,7	apoptosis_signal-regulating_kinase_1	17,53	Ghrelin	apoptosis signal-regulating kinase 1	59301(Tax:10116)	365057(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Ghrelin inhibits apoptosis_signal-regulating_kinase_1 activity via upregulating heat-shock_protein_70 .
25337654	0	Ghrelin	0,7	c-Jun_N-terminal_kinase	141,164	Ghrelin	c-Jun N-terminal kinase	59301(Tax:10116)	116554(Tax:10116)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Ghrelin protects alveolar macrophages against lipopolysaccharide-induced apoptosis through growth hormone secretagogue receptor 1a-dependent c-Jun_N-terminal_kinase and Wnt/b-catenin signaling and suppresses_lung_inflammation .
21438782	0	Ghrelin	0,7	corticotropin-releasing_factor	19,49	Ghrelin	corticotropin-releasing factor	59301(Tax:10116)	81648(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Ghrelin stimulates corticotropin-releasing_factor and vasopressin gene expression in rat hypothalamic 4B cells .
26874559	0	Ghrelin	0,7	corticotropin-releasing_factor	35,65	Ghrelin	corticotropin-releasing factor	58991(Tax:10090)	12918(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|neurons neurons|amod|END_ENTITY	Ghrelin activates hypophysiotropic corticotropin-releasing_factor neurons independently of the arcuate nucleus .
17065340	0	Ghrelin	0,7	glucagon-like_peptide-1	45,68	Ghrelin	glucagon-like peptide-1	59301(Tax:10116)	24952(Tax:10116)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|effects effects|nmod|END_ENTITY	Ghrelin attenuates the inhibitory effects of glucagon-like_peptide-1 and peptide_YY -LRB- 3-36 -RRB- on food intake and gastric emptying in rats .
11306336	0	Ghrelin	0,7	growth_hormone	60,74	Ghrelin	growth hormone	59301(Tax:10116)	2688	Gene	Gene	START_ENTITY|dep|discovery discovery|nmod|endogenous endogenous|acl|ligand ligand|nmod|receptor receptor|amod|END_ENTITY	Ghrelin : discovery of the natural endogenous ligand for the growth_hormone secretagogue receptor .
15363972	0	Ghrelin	0,7	growth_hormone	110,124	Ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|adipocytes adipocytes|nmod|receptor receptor|compound|END_ENTITY	Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth_hormone secretagogue receptor .
15478030	0	Ghrelin	0,7	growth_hormone	22,36	Ghrelin	growth hormone	58991(Tax:10090)	2688	Gene	Gene	secretagogues|compound|START_ENTITY secretagogues|compound|END_ENTITY	Ghrelin and synthetic growth_hormone secretagogues are cardioactive molecules with identities and differences .
17109935	0	Ghrelin	0,7	growth_hormone	19,33	Ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Ghrelin stimulates growth_hormone secretion and food intake in aged rats .
17556866	0	Ghrelin	0,7	growth_hormone	17,31	Ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	improves|nsubj|START_ENTITY improves|dobj|responses responses|amod|END_ENTITY	Ghrelin improves growth_hormone responses to growth_hormone-releasing hormone in a streptozotocin-diabetic model of delayed onset .
21777303	0	Ghrelin	0,7	growth_hormone-releasing_hormone	97,129	Ghrelin	growth hormone-releasing hormone	58991(Tax:10090)	14601(Tax:10090)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Ghrelin and obestatin_modulate growth_hormone-releasing_hormone release and synaptic inputs onto growth_hormone-releasing_hormone neurons .
16552751	0	Ghrelin	0,7	interleukin-8	19,32	Ghrelin	interleukin-8	58991(Tax:10090)	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells .
23877278	0	Ghrelin	0,7	mTOR	84,88	Ghrelin	mTOR	58991(Tax:10090)	21977(Tax:10090)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|advcl|activating activating|dobj|END_ENTITY	Ghrelin attenuates intestinal_ischemia / reperfusion injury in mice by activating the mTOR signaling pathway .
26279396	0	Ghrelin	0,7	mTOR	43,47	Ghrelin	mTOR	58991(Tax:10090)	21977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ghrelin regulates GLP-1 production through mTOR signaling in L cells .
23832961	0	Ghrelin	0,7	p53	17,20	Ghrelin	p53	58991(Tax:10090)	22060(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Ghrelin requires p53 to stimulate lipid storage in fat and liver .
15103226	0	Ghrelin	0,7	prolactin	17,26	Ghrelin	prolactin	59301(Tax:10116)	24683(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Ghrelin inhibits prolactin secretion in prepubertal rats .
24024131	0	Ghrelin	0,7	prolyl_carboxypeptidase	31,54	Ghrelin	prolyl carboxypeptidase	58991(Tax:10090)	72461(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Ghrelin regulates hypothalamic prolyl_carboxypeptidase expression in mice .
17475246	0	Giantin	0,7	Rab6	45,49	Giantin	Rab6	2804	5870	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Giantin interacts with both the small GTPase Rab6 and Rab1 .
22918946	0	Gic2p	69,74	Cdc42p	0,6	Gic2p	Cdc42p	851904(Tax:4932)	850930(Tax:4932)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|regulation regulation|amod|END_ENTITY	Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p .
16303566	0	Gigaxonin	0,9	tubulin_folding_cofactor_B	25,51	Gigaxonin	tubulin folding cofactor B	8139	1155	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Gigaxonin interacts with tubulin_folding_cofactor_B and controls its degradation through the ubiquitin-proteasome pathway .
16861226	0	Gin4	63,67	Elm1	71,75	Gin4	Elm1	852119(Tax:4932)	853818(Tax:4932)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast .
19598108	0	Gitrl	61,66	Glucocorticoid-Induced_TNF_Receptor_Ligand	17,59	Gitrl	Glucocorticoid-Induced TNF Receptor Ligand	100148577(Tax:7955)	100148577(Tax:7955)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for Glucocorticoid-Induced_TNF_Receptor_Ligand -LRB- Gitrl -RRB- in early embryonic zebrafish development .
24048574	0	Gja1	113,117	connexin43	119,129	Gja1	connexin43	14609(Tax:10090)	14609(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Decidual angiogenesis and placental orientation are altered in mice heterozygous for a dominant loss-of-function Gja1 -LRB- connexin43 -RRB- mutation .
16271086	0	Gja3	69,73	connexin_46	56,67	Gja3	connexin 46	79217(Tax:10116)	79217(Tax:10116)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	New genetic model rat for congenital_cataracts due to a connexin_46 -LRB- Gja3 -RRB- mutation .
11875045	0	Gja8	2,6	Cx50	8,12	Gja8	Cx50	14616(Tax:10090)	14616(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	A Gja8 -LRB- Cx50 -RRB- point mutation causes an alteration of alpha_3_connexin -LRB- Cx46 -RRB- in semi-dominant cataracts of Lop10 mice .
7904478	0	Gla	38,41	coagulation_factor_IX	67,88	Gla	coagulation factor IX	2717	2158	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Ca -LRB- 2 + -RRB- - dependent interactions between Gla and EGF domains in human coagulation_factor_IX .
24685139	0	Glc7	74,78	Rif1	0,4	Glc7	Rif1	856870(Tax:4932)	852578(Tax:4932)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7 .
17898076	0	Glc7p	84,89	Scd5p	0,5	Glc7p	Scd5p	856870(Tax:4932)	854507(Tax:4932)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast .
15728736	0	GlcNAc6ST-1	98,109	CD44	196,200	GlcNAc6ST-1	CD44	9435	960	Gene	Gene	implicated|nsubjpass|START_ENTITY implicated|nmod|END_ENTITY	Expression of N-acetylglucosamine 6-O-sulfotransferases -LRB- GlcNAc6STs -RRB- -1 _ and _ -4 in human monocytes : GlcNAc6ST-1 is implicated in the generation of the 6-sulfo_N-acetyllactosamine / Lewis x epitope on CD44 and is induced by TNF-alpha .
19684112	0	Gli	33,36	Sufu	57,61	Gli	Sufu	34927(Tax:7227)	41565(Tax:7227)	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved .
23469687	0	Gli-1	62,67	Bcl-2	68,73	Gli-1	Bcl-2	2735	596	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Zerumbone induces apoptosis in human renal_cell_carcinoma via Gli-1 / Bcl-2 pathway .
26945969	0	Gli-1	114,119	PCAF	0,4	Gli-1	PCAF	2735	8850	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	PCAF inhibits hepatocellular_carcinoma metastasis by inhibition of epithelial-mesenchymal transition by targeting Gli-1 .
20516124	0	Gli1	62,66	Atoh1	0,5	Gli1	Atoh1	14632(Tax:10090)	11921(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells .
24064361	0	Gli1	18,22	Dlk1	0,4	Gli1	Dlk1	140589(Tax:10116)	114587(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Dlk1 up-regulates Gli1 expression in male rat adrenal capsule cells through the activation of b1 integrin and ERK1/2 .
12183437	0	Gli1	32,36	FOXM1	0,5	Gli1	FOXM1	2735	2305	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	FOXM1 is a downstream target of Gli1 in basal_cell_carcinomas .
21169257	0	Gli1	41,45	Hes1	17,21	Gli1	Hes1	2735	3280	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling : a potential mechanism of therapeutic resistance .
22001340	0	Gli1	99,103	NF-kB	47,52	Gli1	NF-kB	140589(Tax:10116)	81736(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Polydatin modulates inflammation by decreasing NF-kB activation and oxidative stress by increasing Gli1 , Ptch1 , SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain .
25289083	0	Gli1	15,19	PKM2	0,4	Gli1	PKM2	2735	5315	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PKM2 regulates Gli1 expression in hepatocellular_carcinoma .
26762411	0	Gli1	52,56	Protein_arginine_methyltransferase_1	0,36	Gli1	Protein arginine methyltransferase 1	2735	3276	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protein_arginine_methyltransferase_1 interacts with Gli1 and regulates its transcriptional activity .
17297467	0	Gli1	0,4	Snail	18,23	Gli1	Snail	14632(Tax:10090)	20613(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin .
12221011	0	Gli1	37,41	Sonic_hedgehog	0,14	Gli1	Sonic hedgehog	2735	6469	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Sonic_hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation .
22266871	0	Gli1	14,18	c-Jun	38,43	Gli1	c-Jun	2735	3725	Gene	Gene	results|amod|START_ENTITY results|nmod|activation activation|amod|END_ENTITY	Inhibition of Gli1 results in altered c-Jun activation , inhibition of cisplatin-induced upregulation of ERCC1 , XPD and XRCC1 , and inhibition of platinum-DNA adduct repair .
26896768	0	Gli2	59,63	Aldehyde_dehydrogenase_1A1	0,26	Gli2	Aldehyde dehydrogenase 1A1	2736	216	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Aldehyde_dehydrogenase_1A1 stabilizes transcription factor Gli2 and enhances the activity of Hedgehog signaling in hepatocellular_cancer .
10074179	0	Gli2	15,19	CREB	25,29	Gli2	CREB	2736	1385	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Interaction of Gli2 with CREB protein on DNA elements in the long terminal repeat of human_T-cell_leukemia_virus_type_1 is responsible for transcriptional activation by tax protein .
23034632	0	Gli2	15,19	Kif7	0,4	Gli2	Kif7	2736	374654	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Kif7 regulates Gli2 through Sufu-dependent and - independent functions during skin development and tumorigenesis .
24036067	0	Gli2	21,25	Pax3	0,4	Gli2	Pax3	2736	5077	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer .
12361967	0	Gli2	0,4	Shh	44,47	Gli2	Shh	14633(Tax:10090)	20423(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|signaling signaling|compound|END_ENTITY	Gli2 , but not Gli1 , is required for initial Shh signaling and ectopic activation of the Shh pathway .
22395235	0	Gli2	19,23	TGF-b	10,15	Gli2	TGF-b	2736	7040	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of TGF-b on Gli2 expression in HL60 and U937 cell lines .
16880529	0	Gli2	37,41	bone_morphogenetic_protein_2	51,79	Gli2	bone morphogenetic protein 2	2736	650	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	The zinc finger transcription factor Gli2 mediates bone_morphogenetic_protein_2 expression in osteoblasts in response to hedgehog signaling .
19103752	0	Gli2	149,153	bone_morphogenetic_protein_2	61,89	Gli2	bone morphogenetic protein 2	14633(Tax:10090)	12156(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of microtubule assembly in osteoblasts stimulates bone_morphogenetic_protein_2 expression and bone formation through transcription factor Gli2 .
18927476	0	Gli2	0,4	sox2	29,33	Gli2	sox2	14633(Tax:10090)	20674(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells .
16141219	0	Gli3	51,55	Ihh	0,3	Gli3	Ihh	14634(Tax:10090)	16147(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Ihh controls cartilage development by antagonizing Gli3 , but requires additional effectors to regulate osteoblast and vascular development .
17334602	0	Gli3	19,23	extra-toes	25,35	Gli3	extra-toes	14634(Tax:10090)	14634(Tax:10090)	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Involvement of the Gli3 -LRB- extra-toes -RRB- gene region in body weight in mice .
23677465	0	Glia_maturation_factor-y	0,24	TLR4	46,50	Glia maturation factor-y	TLR4	9535	7099	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Glia_maturation_factor-y negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages .
23677465	0	Glia_maturation_factor-y	0,24	TLR4	77,81	Glia maturation factor-y	TLR4	9535	7099	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|TLR4 TLR4|acl|signaling signaling|advcl|facilitating facilitating|dobj|trafficking trafficking|nummod|END_ENTITY	Glia_maturation_factor-y negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages .
10550003	0	Glial-Derived_Neurotrophic_Factor	18,51	GDNF	53,57	Glial-Derived Neurotrophic Factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Ethanol decreases Glial-Derived_Neurotrophic_Factor -LRB- GDNF -RRB- protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum .
17030186	0	Glial-derived_neurotrophic_factor	0,33	neuropeptide_Y	96,110	Glial-derived neurotrophic factor	neuropeptide Y	14573(Tax:10090)	109648(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Glial-derived_neurotrophic_factor modulates enteric neuronal survival and proliferation through neuropeptide_Y .
25789543	0	Glial_Fibrillary_Acidic_Protein	54,85	Glial_Fibrillary_Acidic_Protein	6,37	Glial Fibrillary Acidic Protein	Glial Fibrillary Acidic Protein	2670	2670	Gene	Gene	Products|compound|START_ENTITY Products|compound|END_ENTITY	Serum Glial_Fibrillary_Acidic_Protein Predicts Tissue Glial_Fibrillary_Acidic_Protein Break-Down Products and Therapeutic Efficacy after Penetrating Ballistic-Like Brain_Injury .
25789543	0	Glial_Fibrillary_Acidic_Protein	6,37	Glial_Fibrillary_Acidic_Protein	54,85	Glial Fibrillary Acidic Protein	Glial Fibrillary Acidic Protein	2670	2670	Gene	Gene	Products|compound|START_ENTITY Products|compound|END_ENTITY	Serum Glial_Fibrillary_Acidic_Protein Predicts Tissue Glial_Fibrillary_Acidic_Protein Break-Down Products and Therapeutic Efficacy after Penetrating Ballistic-Like Brain_Injury .
25613134	0	Glial_Fibrillary_Acidic_Protein	83,114	STAT3	0,5	Glial Fibrillary Acidic Protein	STAT3	2670	6774	Gene	Gene	Transactivation|nmod|START_ENTITY Involved|nmod|Transactivation Involved|nsubjpass|END_ENTITY	STAT3 and its Phosphorylation are Involved in HIV-1 Tat-induced Transactivation of Glial_Fibrillary_Acidic_Protein .
12947332	0	Glial_cell-derived_neurotrophic_factor	0,38	matrix_metalloproteinase-9	84,110	Glial cell-derived neurotrophic factor	matrix metalloproteinase-9	2668	4318	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Glial_cell-derived_neurotrophic_factor upregulates the expression and activation of matrix_metalloproteinase-9 in human pancreatic_cancer .
7854063	0	Glial_cell-line_derived_neurotrophic_factor	0,43	GDNF	45,49	Glial cell-line derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Glial_cell-line_derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA upregulation in striatum and cortical areas after pilocarpine-induced status_epilepticus in rats .
11600185	0	Glial_cell_line-derived_neurotrophic_factor	0,43	GDNF	45,49	Glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene and schizophrenia : polymorphism screening and association analysis .
9013392	0	Glial_cell_line-derived_neurotrophic_factor	0,43	GDNF	45,49	Glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene expression in the human brain : a post mortem in situ hybridization study with special reference to Parkinson 's _ disease .
20369355	0	Glial_cell_line-derived_neurotrophic_factor	0,43	GFRA2	62,67	Glial cell line-derived neurotrophic factor	GFRA2	2668	2675	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor receptor alpha 2 -LRB- GFRA2 -RRB- gene is associated with tardive_dyskinesia .
15211107	0	Glial_cell_line-derived_neurotrophic_factor	0,43	nuclear_factor-kappaB	53,74	Glial cell line-derived neurotrophic factor	nuclear factor-kappaB	2668	4790	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor enhances nuclear_factor-kappaB activity and invasive potential in human pancreatic_cancer cells .
18160678	0	Glial_cell_missing_1	0,20	placental_growth_factor	31,54	Glial cell missing 1	placental growth factor	8521	5228	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	Glial_cell_missing_1 regulates placental_growth_factor -LRB- PGF -RRB- gene transcription in human trophoblast .
23321059	0	Glial_fibrillary_acidic_protein	34,65	QKI	20,23	Glial fibrillary acidic protein	QKI	2670	9444	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNA-binding protein QKI regulates Glial_fibrillary_acidic_protein expression in human astrocytes .
10098836	0	Glial_fibrillary_acidic_protein	0,31	transforming_growth_factor-beta1	59,91	Glial fibrillary acidic protein	transforming growth factor-beta1	24387(Tax:10116)	59086(Tax:10116)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Glial_fibrillary_acidic_protein transcription responses to transforming_growth_factor-beta1 and interleukin-1beta are mediated by a nuclear factor-1-like site in the near-upstream promoter .
22820919	0	Glis3	0,5	neurogenin_3	16,28	Glis3	neurogenin 3	169792	50674	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Glis3 regulates neurogenin_3 expression in pancreatic b-cells and interacts with its activator , Hnf6 .
11096087	0	Gln3p	69,74	APG14	14,19	Gln3p	APG14	856763(Tax:4932)	852425(Tax:4932)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of APG14 expression by the GATA-type transcription factor Gln3p .
22405651	0	Glomulin	37,45	Rbx1	52,56	Glomulin	Rbx1	11146	9978	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The glomuvenous_malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7 .
26051932	0	GluA1	51,56	FMRP	19,23	GluA1	FMRP	14799(Tax:10090)	14265(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|dep|Expression	Fragile_X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms .
25224260	1	GluA1	106,111	GRIA1	99,104	GluA1	GRIA1	14799(Tax:10090)	14799(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	A role for impaired short-term habituation and the GRIA1 -LRB- GluA1 -RRB- AMPA receptor subunit .
24567325	0	GluA1	32,37	SAP97	87,92	GluA1	SAP97	2890	1739	Gene	Gene	receptors|amod|START_ENTITY delivery|nmod|receptors delivery|nmod|END_ENTITY	Sequential delivery of synaptic GluA1 - and GluA4-containing AMPA receptors -LRB- AMPARs -RRB- by SAP97 anchored protein complexes in classical conditioning .
26149358	0	GluA1	24,29	SAP97	49,54	GluA1	SAP97	2890	1739	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	A Critical Role for the GluA1 Accessory Protein , SAP97 , in Cocaine Seeking .
21419184	0	GluA2	37,42	GluR2	30,35	GluA2	GluR2	2891	2891	Gene	Gene	subunits|appos|START_ENTITY subunits|compound|END_ENTITY	Upregulation of AMPA receptor GluR2 -LRB- GluA2 -RRB- subunits in subcortical_ischemic_vascular_dementia is repressed in the presence of Alzheimer 's _ disease .
26991362	0	GluK1	30,35	NETO1	49,54	GluK1	NETO1	2897	81832	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Pharmacological Modulation of GluK1 and GluK2 by NETO1 , NETO2 , and PSD95 .
26277340	0	GluK1	95,100	Neto1	23,28	GluK1	Neto1	2897	81832	Gene	Gene	effects|nmod|START_ENTITY have|dobj|effects have|nsubj|END_ENTITY	The auxiliary subunits Neto1 and Neto2 have distinct , subunit-dependent effects at recombinant GluK1 - and GluK2-containing kainate receptors .
24413569	0	GluN2A	90,96	TSPYL2	32,38	GluN2A	TSPYL2	14811(Tax:10090)	52808(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B .
26500840	0	GluN2B	23,29	AgRP	56,60	GluN2B	AgRP	14812(Tax:10090)	11604(Tax:10090)	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis .
21768120	0	GluN2B	171,177	CaMKII	103,109	GluN2B	CaMKII	2904	818	Gene	Gene	subunit|dobj|START_ENTITY subunit|nsubj|II II|appos|END_ENTITY	Nucleotides and phosphorylation bi-directionally modulate Ca2 + / calmodulin-dependent protein kinase II -LRB- CaMKII -RRB- binding to the N-methyl-D-aspartate -LRB- NMDA -RRB- receptor subunit GluN2B .
22234183	0	GluN2B	18,24	CaMKII	0,6	GluN2B	CaMKII	14812(Tax:10090)	108058(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	CaMKII binding to GluN2B is critical during memory consolidation .
23478024	0	GluN2B	25,31	CaMKII	10,16	GluN2B	CaMKII	2904	818	Gene	Gene	kinase|nsubj|START_ENTITY couples|ccomp|kinase couples|nsubj|END_ENTITY	Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors .
24056996	0	GluN2B	101,107	CaMKII	22,28	GluN2B	CaMKII	2904	818	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|activity activity|nmod|END_ENTITY	Enzymatic activity of CaMKII is not required for its interaction with the glutamate receptor subunit GluN2B .
24796865	0	GluN2B	18,24	CaMKII	0,6	GluN2B	CaMKII	2904	818	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents .
25187880	0	GluN2B	18,24	CaMKII	0,6	GluN2B	CaMKII	14812(Tax:10090)	108058(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	CaMKII binding to GluN2B is important for massed spatial learning in the Morris water maze .
26690829	0	GluN2B	43,49	GRIN2B	63,69	GluN2B	GRIN2B	2904	2904	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Combined effect of genetic variants in the GluN2B coding gene -LRB- GRIN2B -RRB- on prefrontal function during working memory performance .
22564863	0	GluN3A	55,61	GluN3B	43,49	GluN3A	GluN3B	191573(Tax:10116)	170796(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors .
22564863	0	GluN3B	43,49	GluN3A	55,61	GluN3B	GluN3A	170796(Tax:10116)	191573(Tax:10116)	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors .
18394473	0	GluR-A	16,22	GluR1	24,29	GluR-A	GluR1	14799(Tax:10090)	14799(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The role of the GluR-A -LRB- GluR1 -RRB- AMPA receptor subunit in learning and memory .
10822164	0	GluR-A	121,127	glutamate_receptor_A	99,119	GluR-A	glutamate receptor A	50592(Tax:10116)	50592(Tax:10116)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	An autoradiographic study of -LSB- 3H -RSB- AMPA receptor binding and in situ hybridization of AMPA sensitive glutamate_receptor_A -LRB- GluR-A -RRB- subunits following morphine withdrawal in the rat brain .
16326431	0	GluR-A	161,167	glutamate_receptor_A	139,159	GluR-A	glutamate receptor A	50592(Tax:10116)	50592(Tax:10116)	Gene	Gene	subunits|appos|START_ENTITY subunits|compound|END_ENTITY	Increases in -LSB- -LRB- 3 -RRB- H -RSB- - alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- receptor binding and mRNA expression of AMPA-sensitive glutamate_receptor_A -LRB- GluR-A -RRB- subunits in rats withdrawn from butorphanol .
12070168	0	GluR-A	54,60	synapse-associated_protein_97	21,50	GluR-A	synapse-associated protein 97	2890	1739	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Selective binding of synapse-associated_protein_97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole_propionate receptor subunit is determined by a novel sequence motif .
18394473	0	GluR1	24,29	GluR-A	16,22	GluR1	GluR-A	14799(Tax:10090)	14799(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The role of the GluR-A -LRB- GluR1 -RRB- AMPA receptor subunit in learning and memory .
10971623	0	GluR1	7,12	GluR2	15,20	GluR1	GluR2	50592(Tax:10116)	29627(Tax:10116)	Gene	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	A high GluR1 : GluR2 expression ratio is correlated with expression of Ca2 + - binding proteins in rat forebrain neurons .
22302822	0	GluR1	14,19	Hes-1	110,115	GluR1	Hes-1	50592(Tax:10116)	29577(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1 .
14678750	0	GluR1	88,93	Narp	26,30	GluR1	Narp	50592(Tax:10116)	288475(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior_colliculus of P77PMC rats .
16980545	0	GluR1	53,58	PDZ-protein	25,36	GluR1	PDZ-protein	2890	10207	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity .
9825961	0	GluR2	23,28	CA3	58,61	GluR2	CA3	2891	761	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Selective reduction of GluR2 protein in adult hippocampal CA3 neurons following status_epilepticus but prior to cell loss .
16262247	0	GluR2	25,30	GMP	14,17	GluR2	GMP	2891	22978	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Binding of 5 ' - GMP to the GluR2 AMPA receptor : insight from targeted_molecular_dynamics simulations .
21419184	0	GluR2	30,35	GluA2	37,42	GluR2	GluA2	2891	2891	Gene	Gene	subunits|compound|START_ENTITY subunits|appos|END_ENTITY	Upregulation of AMPA receptor GluR2 -LRB- GluA2 -RRB- subunits in subcortical_ischemic_vascular_dementia is repressed in the presence of Alzheimer 's _ disease .
10971623	0	GluR2	15,20	GluR1	7,12	GluR2	GluR1	29627(Tax:10116)	50592(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|dep|ratio	A high GluR1 : GluR2 expression ratio is correlated with expression of Ca2 + - binding proteins in rat forebrain neurons .
12130635	0	GluR2	185,190	N-ethylmaleimide-sensitive_factor	151,184	GluR2	N-ethylmaleimide-sensitive factor	2891	4905	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Brain-derived_neurotrophic_factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid receptors by enhancing the N-ethylmaleimide-sensitive_factor / GluR2 interaction in developing neocortical neurons .
15797712	0	GluR2	53,58	NSF	0,3	GluR2	NSF	2891	4905	Gene	Gene	insertion|nmod|START_ENTITY important|nmod|insertion important|nsubj|interaction interaction|compound|END_ENTITY	NSF interaction is important for direct insertion of GluR2 at synaptic sites .
17302911	0	GluR2	73,78	NSF	0,3	GluR2	NSF	2891	4905	Gene	Gene	regulate|nmod|START_ENTITY binds|advcl|regulate binds|nsubj|END_ENTITY	NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2 .
18598260	0	GluR2	112,117	NSF	43,46	GluR2	NSF	2891	4905	Gene	Gene	switch|amod|START_ENTITY involved|nmod|switch involved|nsubjpass|N-ethylmaleimide-sensitive_fusion_protein N-ethylmaleimide-sensitive_fusion_protein|appos|END_ENTITY	N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation .
9697854	0	GluR2	15,20	NSF	0,3	GluR2	NSF	29627(Tax:10116)	60355(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	NSF binding to GluR2 regulates synaptic transmission .
9697855	0	GluR2	18,23	NSF	92,95	GluR2	NSF	2891	4905	Gene	Gene	START_ENTITY|ccomp|mediate mediate|dobj|interaction interaction|nmod|END_ENTITY	The AMPA receptor GluR2 C terminus can mediate a reversible , ATP-dependent interaction with NSF and alpha - _ and_beta-SNAPs .
18077702	0	GluR2	55,60	glutamate_receptor_2	33,53	GluR2	glutamate receptor 2	2891	2891	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
15450689	0	GluR4	74,79	GRIA4	86,91	GluR4	GRIA4	2893	2893	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No genetic association between polymorphisms in the AMPA receptor subunit GluR4 gene -LRB- GRIA4 -RRB- and schizophrenia in the Chinese population .
9259378	0	GluR5	56,61	GRIK1	85,90	GluR5	GRIK1	2897	2897	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic association of juvenile_absence_epilepsy with a GluR5 kainate receptor gene -LRB- GRIK1 -RRB- polymorphism .
8034316	0	GluR6	6,11	GRIK2	30,35	GluR6	GRIK2	2898	2898	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Human GluR6 kainate receptor -LRB- GRIK2 -RRB- : molecular cloning , expression , polymorphism , and chromosomal assignment .
7719709	0	GluR7	46,51	EAA5	40,44	GluR7	EAA5	2899	2899	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Molecular characterization of the human EAA5 -LRB- GluR7 -RRB- receptor : a high-affinity kainate receptor with novel potential RNA editing sites .
12103442	0	GluR_epsilon_1	29,43	NR2A	45,49	GluR epsilon 1	NR2A	14811(Tax:10090)	14811(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Early onset of NMDA receptor GluR_epsilon_1 -LRB- NR2A -RRB- expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus .
20537373	0	GluRdelta2	30,40	Cbln1	62,67	GluRdelta2	Cbln1	14804(Tax:10090)	869	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum .
15385364	0	GluRepsilon1	100,112	N-methyl-D-aspartate_receptor	70,99	GluRepsilon1	N-methyl-D-aspartate receptor	14811(Tax:10090)	14810(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Reduced sensitivity to ketamine and pentobarbital in mice lacking the N-methyl-D-aspartate_receptor GluRepsilon1 subunit .
25716866	0	Glua1	114,119	MeCP2	94,99	Glua1	MeCP2	50592(Tax:10116)	29386(Tax:10116)	Gene	Gene	Repression|nmod|START_ENTITY Repression|amod|END_ENTITY	Persistent Pain Maintains Morphine-Seeking Behavior after Morphine Withdrawal through Reduced MeCP2 Repression of Glua1 in Rat Central Amygdala .
8164696	0	Glucagon	0,8	hepatocyte_nuclear_factor_3_beta	52,84	Glucagon	hepatocyte nuclear factor 3 beta	24952(Tax:10116)	25099(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Glucagon gene expression is negatively regulated by hepatocyte_nuclear_factor_3_beta .
26218441	0	Glucagon-Like_Peptide_1	47,70	miR-132	13,20	Glucagon-Like Peptide 1	miR-132	2641	406921	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Induction of miR-132 and miR-212 Expression by Glucagon-Like_Peptide_1 -LRB- GLP-1 -RRB- in Rodent and Human Pancreatic b-Cells .
26971825	0	Glucagon-like_Peptide	52,73	Glucose-dependent_Insulinotropic_Peptide	0,40	Glucagon-like Peptide	Glucose-dependent Insulinotropic Peptide	14526(Tax:10090)	14607(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Stimulates Stimulates|compound|END_ENTITY	Glucose-dependent_Insulinotropic_Peptide Stimulates Glucagon-like_Peptide 1 Production by Pancreatic Islets via Interleukin-6 , Produced by a Cells .
17584962	0	Glucagon-like_peptide-1	0,23	GLP-1	25,30	Glucagon-like peptide-1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats .
20835917	0	Glucagon-like_peptide-1	0,23	GLP-1	25,30	Glucagon-like peptide-1	GLP-1	2641	2641	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass .
16720054	0	Glucagon-like_peptide-1	0,23	IL-1beta	45,53	Glucagon-like peptide-1	IL-1beta	24952(Tax:10116)	24494(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Glucagon-like_peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes .
11532906	0	Glucagon-like_peptide-1	0,23	cAMP	34,38	Glucagon-like peptide-1	cAMP	24952(Tax:10116)	316010(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Glucagon-like_peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes .
14534075	0	Glucagon-like_peptide-1	0,23	insulin	84,91	Glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|increase increase|nmod|i i|acl|associated associated|nmod|secretion secretion|compound|END_ENTITY	Glucagon-like_peptide-1 induces a cAMP-dependent increase of -LSB- Na + -RSB- i associated with insulin secretion in pancreatic beta-cells .
16079261	0	Glucagon-like_peptide-1	0,23	insulin	41,48	Glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Glucagon-like_peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site .
24688145	0	Glucagon-like_peptide-1	0,23	insulin	49,56	Glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	agonists|amod|START_ENTITY agonists|nmod|glargine glargine|compound|END_ENTITY	Glucagon-like_peptide-1 receptor agonists versus insulin glargine for type_2_diabetes_mellitus : A systematic review and meta-analysis of randomized controlled trials .
8586147	0	Glucagon-like_peptide-1	0,23	insulin	39,46	Glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Glucagon-like_peptide-1 and control of insulin secretion .
9338524	0	Glucagon-like_peptide-1	0,23	insulin	78,85	Glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Glucagon-like_peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans .
23670349	0	Glucagon-like_peptide-1	0,23	visfatin	36,44	Glucagon-like peptide-1	visfatin	2641	10135	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Glucagon-like_peptide-1 upregulates visfatin expression in 3T3-L1 adipocytes .
8895391	0	Glucagon-like_peptide-1_receptor	0,32	GLP1-R	34,40	Glucagon-like peptide-1 receptor	GLP1-R	25051(Tax:10116)	25051(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Glucagon-like_peptide-1_receptor -LRB- GLP1-R -RRB- mRNA in the rat hypothalamus .
21454584	0	Glucagon-like_peptide_1	0,23	glucokinase	68,79	Glucagon-like peptide 1	glucokinase	14526(Tax:10090)	103988(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Glucagon-like_peptide_1 stimulates post-translational activation of glucokinase in pancreatic beta cells .
22895780	0	Glucagon-like_peptide_2	0,23	vasoactive_intestinal_polypeptide	32,65	Glucagon-like peptide 2	vasoactive intestinal polypeptide	2641	7432	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Glucagon-like_peptide_2 induces vasoactive_intestinal_polypeptide expression in enteric neurons via phophatidylinositol 3-kinase-y signaling .
26330822	0	Glucagon_peptide-like_1_receptor	0,32	GLP-1R	34,40	Glucagon peptide-like 1 receptor	GLP-1R	2740	2740	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucagon_peptide-like_1_receptor -LRB- GLP-1R -RRB- expression per se : a new insight into neurodegenerative_disease ?
19598108	0	Glucocorticoid-Induced_TNF_Receptor_Ligand	17,59	Gitrl	61,66	Glucocorticoid-Induced TNF Receptor Ligand	Gitrl	100148577(Tax:7955)	100148577(Tax:7955)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for Glucocorticoid-Induced_TNF_Receptor_Ligand -LRB- Gitrl -RRB- in early embryonic zebrafish development .
20936139	0	Glucocorticoid-induced_TNFR-related	0,35	GITR	37,41	Glucocorticoid-induced TNFR-related	GITR	8784	8784	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Glucocorticoid-induced_TNFR-related -LRB- GITR -RRB- protein and its ligand in antitumor immunity : functional role and therapeutic modulation .
16285015	0	Glucocorticoid-induced_TNFR_family-related_protein	0,50	GITR	52,56	Glucocorticoid-induced TNFR family-related protein	GITR	21936(Tax:10090)	21936(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Glucocorticoid-induced_TNFR_family-related_protein -LRB- GITR -RRB- activation exacerbates murine asthma and collagen-induced arthritis .
17910039	0	Glucocorticoid-induced_leucine_zipper	0,37	GILZ	39,43	Glucocorticoid-induced leucine zipper	GILZ	1831	1831	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- mediates glucocorticoid action and inhibits inflammatory cytokine-induced COX-2 expression .
17169985	0	Glucocorticoid-induced_leucine_zipper	0,37	NF-kappaB	45,54	Glucocorticoid-induced leucine zipper	NF-kappaB	1831	4790	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- / NF-kappaB interaction : role of GILZ homo-dimerization and C-terminal domain .
22468037	0	Glucocorticoid_Receptor	40,63	Bcl-1	13,18	Glucocorticoid Receptor	Bcl-1	2908	595	Gene	Gene	Gene|compound|START_ENTITY Polymorphism|nmod|Gene Polymorphism|compound|END_ENTITY	Influence of Bcl-1 Gene Polymorphism of Glucocorticoid_Receptor Gene -LRB- NR3C1 , rs41423247 -RRB- on Blood Pressure , Glucose in Northern Indians .
25358426	0	Glucocorticoid_Receptor	25,48	Bcl1	0,4	Glucocorticoid Receptor	Bcl1	2908	595	Gene	Gene	Gene|compound|START_ENTITY Polymorphism|nmod|Gene Polymorphism|compound|END_ENTITY	Bcl1 Polymorphism of the Glucocorticoid_Receptor Gene and Treatment Response to Milnacipran and Fluvoxamine in Japanese Patients with Depression .
25912394	0	Glucocorticoid_Receptor	23,46	FKBP5	95,100	Glucocorticoid Receptor	FKBP5	2908	2289	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Altered mRNA Levels of Glucocorticoid_Receptor , Mineralocorticoid Receptor , and Co-Chaperones -LRB- FKBP5 and PTGES3 -RRB- in the Middle Frontal Gyrus of Autism Spectrum Disorder Subjects .
16254209	0	Glucocorticoid_receptor	0,23	ATP-binding_cassette_transporter-A1	34,69	Glucocorticoid receptor	ATP-binding cassette transporter-A1	2908	19	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Glucocorticoid_receptor regulates ATP-binding_cassette_transporter-A1 expression and apolipoprotein-mediated cholesterol efflux from macrophages .
14560994	0	Glucocorticoid_receptor	0,23	GR	25,27	Glucocorticoid receptor	GR	2908	2908	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucocorticoid_receptor -LRB- GR -RRB- immunohistochemical expression is correlated with cell cycle-related molecules in human colon_cancer .
9236448	0	Glucocorticoid_receptor	0,23	L-selectin	48,58	Glucocorticoid receptor	L-selectin	2908	6402	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Glucocorticoid_receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils .
24713862	0	Glucocorticoid_receptor	0,23	NR3C1	30,35	Glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glucocorticoid_receptor gene -LRB- NR3C1 -RRB- methylation following stressful events between birth and adolescence .
26073068	0	Glucocorticoid_receptor	0,23	NR3C1	30,35	Glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glucocorticoid_receptor gene -LRB- NR3C1 -RRB- methylation processes as mediators of early adversity in stress-related disorders causality : A critical review .
26782558	0	Glucocorticoid_receptor	0,23	NR3C1	30,35	Glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glucocorticoid_receptor gene -LRB- NR3C1 -RRB- promoter is hypermethylated in Thai females with major depressive_disorder .
25775514	0	Glucocorticoid_receptor	0,23	PNRC2	39,44	Glucocorticoid receptor	PNRC2	2908	55629	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Glucocorticoid_receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation .
19126684	0	Glucocorticoid_receptor	0,23	TrkB	41,45	Glucocorticoid receptor	TrkB	2908	4915	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Glucocorticoid_receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter .
25775514	0	Glucocorticoid_receptor	0,23	UPF1	85,89	Glucocorticoid receptor	UPF1	2908	5976	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Glucocorticoid_receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation .
24399729	0	Glucocorticoid_receptor	0,23	organic_cation_transporter_1	34,62	Glucocorticoid receptor	organic cation transporter 1	2908	6580	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Glucocorticoid_receptor regulates organic_cation_transporter_1 -LRB- OCT1 , SLC22A1 -RRB- expression via HNF4a upregulation in primary human hepatocytes .
10518526	0	Glucocorticoid_receptor	0,23	transforming_growth_factor-beta	33,64	Glucocorticoid receptor	transforming growth factor-beta	2908	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Glucocorticoid_receptor inhibits transforming_growth_factor-beta signaling by directly targeting the transcriptional activation function of Smad3 .
14517946	0	Glucokinase	0,11	GCK	13,16	Glucokinase	GCK	2645	2645	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Glucokinase -LRB- GCK -RRB- mutations in hyper - and hypoglycemia : maturity-onset_diabetes_of_the_young , permanent neonatal diabetes , and hyperinsulinemia of infancy .
24717911	0	Glucokinase	83,94	Glucokinase_Regulatory_Protein	28,58	Glucokinase	Glucokinase Regulatory Protein	2645	2646	Gene	Gene	Activity|compound|START_ENTITY Modulators|dobj|Activity Modulators|nsubj|Discovery Discovery|nmod|END_ENTITY	Discovery of Small-Molecule Glucokinase_Regulatory_Protein Modulators That Restore Glucokinase Activity .
24717911	0	Glucokinase_Regulatory_Protein	28,58	Glucokinase	83,94	Glucokinase Regulatory Protein	Glucokinase	2646	2645	Gene	Gene	Discovery|nmod|START_ENTITY Modulators|nsubj|Discovery Modulators|dobj|Activity Activity|compound|END_ENTITY	Discovery of Small-Molecule Glucokinase_Regulatory_Protein Modulators That Restore Glucokinase Activity .
21318467	0	Glucokinase_regulatory_protein	0,30	GCKR	32,36	Glucokinase regulatory protein	GCKR	2646	2646	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Glucokinase_regulatory_protein -LRB- GCKR -RRB- gene rs4425043 polymorphism is associated with overweight and obesity in Chinese women .
26694452	0	Glucose-6-Phosphate_Dehydrogenase	0,33	HSCARG	101,107	Glucose-6-Phosphate Dehydrogenase	HSCARG	2539	57407	Gene	Gene	Response|compound|START_ENTITY Response|nmod|END_ENTITY	Glucose-6-Phosphate_Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-kB Signaling .
3090637	0	Glucose-6-phosphate-dehydrogenase	0,33	G6PDH	35,40	Glucose-6-phosphate-dehydrogenase	G6PDH	101824850	101824850	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Glucose-6-phosphate-dehydrogenase -LRB- G6PDH -RRB- activity in the liver of golden_hamsters -- its dependence from estrous cycle and consequences on planning experiments .
12850494	0	Glucose-6-phosphate_dehydrogenase	0,33	G-6-PD	35,41	Glucose-6-phosphate dehydrogenase	G-6-PD	2539	2539	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- mutations in Mexico : four new G-6-PD variants .
12956017	0	Glucose-6-phosphate_dehydrogenase	0,33	G-6-PD	35,41	Glucose-6-phosphate dehydrogenase	G-6-PD	2539	2539	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- levels in jaundiced_neonates in Calabar .
19434206	0	Glucose-6-phosphate_dehydrogenase	0,33	G6PD	35,39	Glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- activity and deficiency in a population of Nigerian males resident in Jos. The activity of red blood cell Glucose_6-phosphate dehydrogenase -LRB- G6PD -RRB- in one hundred and twenty six healthy male individuals who are Nigerians residing in Jos was evaluated .
2208076	0	Glucose-6-phosphate_dehydrogenase	0,33	G6PD	35,39	Glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- activity in tumoral tissues of G6PD-deficient subjects affected by larynx_carcinoma .
26395740	0	Glucose-Dependent_Insulinotropic_Polypeptide	0,44	Osteopontin	62,73	Glucose-Dependent Insulinotropic Polypeptide	Osteopontin	2695	6696	Gene	Gene	Stimulates|nsubj|START_ENTITY Stimulates|dobj|Expression Expression|compound|END_ENTITY	Glucose-Dependent_Insulinotropic_Polypeptide -LRB- GIP -RRB- Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB .
26971825	0	Glucose-dependent_Insulinotropic_Peptide	0,40	Glucagon-like_Peptide	52,73	Glucose-dependent Insulinotropic Peptide	Glucagon-like Peptide	14607(Tax:10090)	14526(Tax:10090)	Gene	Gene	Stimulates|compound|START_ENTITY END_ENTITY|nsubj|Stimulates	Glucose-dependent_Insulinotropic_Peptide Stimulates Glucagon-like_Peptide 1 Production by Pancreatic Islets via Interleukin-6 , Produced by a Cells .
8674860	0	Glucose-dependent_insulinotropic_peptide	0,40	GIP	42,45	Glucose-dependent insulinotropic peptide	GIP	25040(Tax:10116)	25040(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glucose-dependent_insulinotropic_peptide -LRB- GIP -RRB- gene expression in the rat salivary gland .
2546060	0	Glucose-regulated_protein	0,25	GRP94	27,32	Glucose-regulated protein	GRP94	7184	7184	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Glucose-regulated_protein -LRB- GRP94 and GRP78 -RRB- genes share common regulatory domains and are coordinately regulated by common trans-acting factors .
26940976	0	Glucose-regulated_protein_78	0,28	SKIP	72,76	Glucose-regulated protein 78	SKIP	3309	51763	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Glucose-regulated_protein_78 -LRB- GRP78 -RRB- binds directly to PIP3 phosphatase SKIP and determines its localization .
26884717	0	Glucose_Oxidase	26,41	Cyclosporine_A	0,14	Glucose Oxidase	Cyclosporine A	15112(Tax:10090)	71991(Tax:10090)	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Cyclosporine_A Suppressed Glucose_Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition .
26884717	0	Glucose_Oxidase	26,41	P53	50,53	Glucose Oxidase	P53	15112(Tax:10090)	22060(Tax:10090)	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Cyclosporine_A Suppressed Glucose_Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition .
12114701	0	Glucose_Transporter-2	35,56	GLUT-2	58,64	Glucose Transporter-2	GLUT-2	6514	6514	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Immunocytochemical Localization of Glucose_Transporter-2 -LRB- GLUT-2 -RRB- in Pancreatic_Islets_and_Islet_Cell_Tumors .
26824929	0	Glucose_Transporter_1	19,40	GLUT1	42,47	Glucose Transporter 1	GLUT1	6513	6513	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Gene Expression of Glucose_Transporter_1 -LRB- GLUT1 -RRB- , Hexokinase_1 and Hexokinase_2 in Gastroenteropancreatic_Neuroendocrine_Tumors : Correlation with F-18-fluorodeoxyglucose Positron Emission Tomography and Cellular Proliferation .
8333327	0	Glucose_transporter	0,19	GLUT1	21,26	Glucose transporter	GLUT1	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucose_transporter -LRB- GLUT1 -RRB- expression by canine brain microvessel endothelial cells in culture : an immunocytochemical study .
8005559	0	Glucose_transporter	0,19	GLUT_4	21,27	Glucose transporter	GLUT 4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Glucose_transporter -LRB- GLUT_4 -RRB- content and insulin receptor kinase activity in muscles of the LA/N-cp rat .
17922867	0	Glucose_transporter-1	0,21	hypoxia_inducible_factor-1_alpha	82,114	Glucose transporter-1	hypoxia inducible factor-1 alpha	6513	3091	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Glucose_transporter-1 expression in renal_cell_carcinoma and its correlation with hypoxia_inducible_factor-1_alpha .
9889355	0	Glucose_transporter_3	0,21	GLUT3	23,28	Glucose transporter 3	GLUT3	6515	6515	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Glucose_transporter_3 -LRB- GLUT3 -RRB- protein is present in human myocardium .
10067007	0	Glucose_transporter_4	0,21	GLUT4	23,28	Glucose transporter 4	GLUT4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Glucose_transporter_4 -LRB- GLUT4 -RRB- mRNA abundance in the adipose tissue and skeletal-muscle tissue of ovariectomized rats treated with 17_beta-estradiol or progesterone .
24519932	0	Glucose_transporter_8	0,21	GLUT8	23,28	Glucose transporter 8	GLUT8	56017(Tax:10090)	56017(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Glucose_transporter_8 -LRB- GLUT8 -RRB- mediates fructose-induced de novo lipogenesis and macrosteatosis .
4084208	0	Glucosephosphate_isomerase	0,26	GPI-1	28,33	Glucosephosphate isomerase	GPI-1	14751(Tax:10090)	14751(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucosephosphate_isomerase -LRB- GPI-1 -RRB- expression in mouse ova : cis regulation of monomer realization .
25281403	0	Glucosylceramide_synthase	0,25	Bcl-2	35,40	Glucosylceramide synthase	Bcl-2	7357	596	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Glucosylceramide_synthase promotes Bcl-2 expression via the ERK signaling pathway in the K562/A02 leukemia drug-resistant cell line .
20735969	0	Glut-1	22,28	Glut-3	30,36	Glut-1	Glut-3	6513	6515	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	-LSB- Relationship between Glut-1 , Glut-3 expression and fluorodeoxyglucose uptake in NSCLC and benign_pulmonary_lesion . -RSB- .
20079187	0	Glut-1	29,35	PTEN	37,41	Glut-1	PTEN	6513	5728	Gene	Gene	proteins|dep|START_ENTITY proteins|dep|END_ENTITY	-LSB- Expression of beta-catenin , Glut-1 , PTEN proteins in uterine endometrioid_adenocarcinoma and its precursor lesions -RSB- .
20079187	0	Glut-1	29,35	beta-catenin	15,27	Glut-1	beta-catenin	6513	1499	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	-LSB- Expression of beta-catenin , Glut-1 , PTEN proteins in uterine endometrioid_adenocarcinoma and its precursor lesions -RSB- .
12529975	0	Glut-1	0,6	glucose_transporter	7,26	Glut-1	glucose transporter	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Glut-1 glucose_transporter expression in esophageal_squamous_cell_carcinoma is associated with tumor_aggressiveness .
2100513	0	Glut-1	40,46	glucose_transporter	19,38	Glut-1	glucose transporter	20525(Tax:10090)	20525(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vanadate regulates glucose_transporter -LRB- Glut-1 -RRB- expression in NIH3T3 mouse fibroblasts .
20735969	0	Glut-3	30,36	Glut-1	22,28	Glut-3	Glut-1	6515	6513	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	-LSB- Relationship between Glut-1 , Glut-3 expression and fluorodeoxyglucose uptake in NSCLC and benign_pulmonary_lesion . -RSB- .
10441390	0	Glut1	14,19	glucose_transporter	20,39	Glut1	glucose transporter	24778(Tax:10116)	24778(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation of Glut1 glucose_transporter in response to inhibition of oxidative phosphorylation .
25492937	0	Glut1	42,47	glucose_transporter_1	49,70	Glut1	glucose transporter 1	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Foxp3-mediated inhibition of Akt inhibits Glut1 -LRB- glucose_transporter_1 -RRB- expression in human T regulatory cells .
24935378	0	Glut1	37,42	miR-186	0,7	Glut1	miR-186	6513	406962	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR-186 regulates glycolysis through Glut1 during the formation of cancer-associated fibroblasts .
11304809	0	Glut3	64,69	glucose_transport_protein	37,62	Glut3	glucose transport protein	25551(Tax:10116)	25551(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Quantitative immunohistochemistry of glucose_transport_protein -LRB- Glut3 -RRB- expression in the rat hippocampus during aging .
21233771	0	Glut4	21,26	MEF2A	0,5	Glut4	MEF2A	20528(Tax:10090)	17258(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|compound|END_ENTITY	MEF2A binding to the Glut4 promoter occurs via an AMPKa2-dependent mechanism .
24632207	0	Glut4	47,52	NR5A2	31,36	Glut4	NR5A2	20528(Tax:10090)	26424(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|Activation Activation|nmod|END_ENTITY	Activation of nuclear receptor NR5A2 increases Glut4 expression and glucose metabolism in muscle cells .
8943343	0	Glut4	72,77	Rab4	18,22	Glut4	Rab4	6517	5867	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes .
20363751	0	Glut4	28,33	ZAC1	48,52	Glut4	ZAC1	25139(Tax:10116)	25157(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of cardiomyocyte Glut4 expression by ZAC1 .
10829031	0	Glut4	73,78	insulin_receptor_substrate-2	18,46	Glut4	insulin receptor substrate-2	20528(Tax:10090)	384783(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY END_ENTITY|nmod|stimulation	Essential role of insulin_receptor_substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes .
1581603	0	Glut_1	32,38	glucose_transporter	11,30	Glut 1	glucose transporter	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pattern of glucose_transporter -LRB- Glut_1 -RRB- expression in embryonic brains is related to maturation of blood-brain barrier tightness .
23904086	0	Glutamate_Decarboxylase	14,37	GAD	39,42	Glutamate Decarboxylase	GAD	24957(Tax:10116)	24957(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of Glutamate_Decarboxylase -LRB- GAD -RRB- mRNA in the brain of bile duct ligated rats serving as a model of hepatic_encephalopathy .
27057365	0	Glutamate_Transporter-1	61,84	Aquaporin-4	49,60	Glutamate Transporter-1	Aquaporin-4	6506	361	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	The Neuroprotective Effect of the Association of Aquaporin-4 / Glutamate_Transporter-1 against Alzheimer 's _ Disease .
19967454	0	Glutamate_decarboxylase	36,59	GAD	61,64	Glutamate decarboxylase	GAD	831599(Tax:3702)	831599(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of a Glutamate_decarboxylase -LRB- GAD -RRB- gene and their differential expression in response to abiotic stresses from Panax ginseng C. A. Meyer .
7808234	0	Glutamate_decarboxylase	0,23	GAD65	25,30	Glutamate decarboxylase	GAD65	2752	2572	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Glutamate_decarboxylase -LRB- GAD65 -RRB- mRNA levels in the striatum and pallidum of MPTP-treated monkeys .
9332731	0	Glutamate_decarboxylase	0,23	GAD65	25,30	Glutamate decarboxylase	GAD65	24380(Tax:10116)	24380(Tax:10116)	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dep|END_ENTITY	Glutamate_decarboxylase -LRB- GAD65 -RRB- gene expression is increased by dopamine receptor agonists in a subpopulation of rat striatal neurons .
9266773	0	Glutamate_decarboxylase	0,23	GAD67	25,30	Glutamate decarboxylase	GAD67	2752	2571	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dep|END_ENTITY	Glutamate_decarboxylase -LRB- GAD67 and GAD65 -RRB- gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian_monkeys .
26601915	0	Glutamate_receptor_interacting_protein_1	0,40	CTLA-4	58,64	Glutamate Receptor Interacting Protein 1	CTLA-4	74053(Tax:10090)	12477(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Glutamate_receptor_interacting_protein_1 regulates CD4 -LRB- + -RRB- CTLA-4 expression and transplant rejection .
26751560	0	Glutaminase_2	0,13	Rac1	60,64	Glutaminase 2	Rac1	27165	5879	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Glutaminase_2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis .
17431186	0	Glutaredoxin	0,12	Akt	22,25	Glutaredoxin	Akt	2745	207	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione_reductase-dependent manner .
1496000	0	Glutaredoxin	0,12	thioltransferase	82,98	Glutaredoxin	thioltransferase	3707602(Tax:10245)	2745	Gene	Gene	homolog|compound|START_ENTITY enzyme|nsubj|homolog enzyme|nmod|activities activities|amod|END_ENTITY	Glutaredoxin homolog encoded by vaccinia_virus is a virion-associated enzyme with thioltransferase and dehydroascorbate reductase activities .
21078302	0	Glutaredoxin-1	0,14	TRAF6	25,30	Glutaredoxin-1	TRAF6	2745	222344	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	Glutaredoxin-1 regulates TRAF6 activation and the IL-1 receptor/TLR4 signalling .
10678584	0	Glutathione-S-Transferase	0,25	jun-N-terminal_kinase	141,162	Glutathione-S-Transferase	jun-N-terminal kinase	373156	5599	Gene	Gene	START_ENTITY|dep|signaling signaling|nmod|END_ENTITY	Glutathione-S-Transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal_kinase .
21855532	0	Glutathione-S-transferase_pi_1	0,30	GSTP1	31,36	Glutathione-S-transferase pi 1	GSTP1	2950	2950	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glutathione-S-transferase_pi_1 -LRB- GSTP1 -RRB- gene silencing in prostate_cancer cells is reversed by the histone deacetylase inhibitor depsipeptide .
21803734	0	Glutathione_S-transferase	0,25	GST	27,30	Glutathione S-transferase	GST	373156	373156	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glutathione_S-transferase -LRB- GST -RRB- gene polymorphisms , cigarette smoking and colorectal_cancer risk among Chinese in Singapore .
24840051	0	Glutathione_S-transferase	0,25	GSTM1	46,51	Glutathione S-transferase	GSTM1	373156	2944	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|dep|END_ENTITY	Glutathione_S-transferase gene polymorphisms -LRB- GSTM1 , GSTT1 , and GSTP1 -RRB- in Egyptian pediatric patients with sickle_cell_disease .
16176403	0	Glutathione_S-transferase_P1	21,49	GSTP1	51,56	Glutathione S-transferase P1	GSTP1	2950	2950	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Association study of Glutathione_S-transferase_P1 -LRB- GSTP1 -RRB- with asthma and bronchial hyper-responsiveness in two German pediatric populations .
26361746	0	Glutathione_S-transferase_P1	0,28	iNOS	40,44	Glutathione S-transferase P1	iNOS	14870(Tax:10090)	18126(Tax:10090)	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Glutathione_S-transferase_P1 suppresses iNOS protein stability in RAW264 .7 macrophage-like cells after LPS stimulation .
27065323	0	Glutathione_S-transferase_alpha_4	0,33	activator_protein_1	47,66	Glutathione S-transferase alpha 4	activator protein 1	2941	3725	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|END_ENTITY	Glutathione_S-transferase_alpha_4 induction by activator_protein_1 in colorectal_cancer .
24664677	0	Glutathione_S-transferase_pi_isoform	0,36	GSTP1	38,43	Glutathione S-transferase pi isoform	GSTP1	14870(Tax:10090)	14870(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glutathione_S-transferase_pi_isoform -LRB- GSTP1 -RRB- expression in murine retina increases with developmental maturity .
23105984	0	Glutathione_S_Transferase	24,49	GST	51,54	Glutathione S Transferase	GST	373156	373156	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Investigate the Role of Glutathione_S_Transferase -LRB- GST -RRB- Polymorphism in Development of Hypertension in UAE Population .
14681495	0	Glutathione_S_transferase_theta_1	0,33	GSTT1	40,45	Glutathione S transferase theta 1	GSTT1	2952	2952	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glutathione_S_transferase_theta_1 gene -LRB- GSTT1 -RRB- null genotype is associated with an increased risk for acquired aplastic_anemia in children .
22174645	0	Glutathione_Transferase	23,46	GstI	53,57	Glutathione Transferase	GstI	542366(Tax:4577)	542366(Tax:4577)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Expression patterns of Glutathione_Transferase Gene -LRB- GstI -RRB- in maize seedlings under juglone-induced oxidative stress .
17097614	0	Glutathione_peroxidase-1	0,24	AP-2alpha	46,55	Glutathione peroxidase-1	AP-2alpha	2876	7020	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Glutathione_peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes .
26773925	0	Glutathione_peroxidase-1	0,24	GPX1	31,35	Glutathione peroxidase-1	GPX1	2876	2876	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glutathione_peroxidase-1 gene -LRB- GPX1 -RRB- variants , oxidative stress and risk_of_kidney_complications in people with type 1 diabetes .
25283363	0	Glutathione_peroxidase_1	57,81	GPx1	83,87	Glutathione peroxidase 1	GPx1	2876	2876	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of Superoxide dismutases -LRB- SOD1 and SOD2 -RRB- and Glutathione_peroxidase_1 -LRB- GPx1 -RRB- gene polymorphisms with Type_2_diabetes_mellitus .
12893824	0	Glutathione_peroxidase_1	0,24	c-Abl	45,50	Glutathione peroxidase 1	c-Abl	2876	25	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Glutathione_peroxidase_1 is regulated by the c-Abl and Arg tyrosine kinases .
16794261	0	Glutathione_peroxidase_2	0,24	Nrf2	103,107	Glutathione peroxidase 2	Nrf2	14776(Tax:10090)	18024(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Glutathione_peroxidase_2 , the major cigarette smoke-inducible isoform of GPX in lungs , is regulated by Nrf2 .
7538131	0	GlyCAM-1	30,38	L-selectin	74,84	GlyCAM-1	L-selectin	644076	6402	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Structure of the O-glycans in GlyCAM-1 , an endothelial-derived ligand for L-selectin .
8879206	0	GlyCAM-1	0,8	L-selectin	35,45	GlyCAM-1	L-selectin	644076	6402	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	GlyCAM-1 , a physiologic ligand for L-selectin , activates beta_2 integrins on naive peripheral lymphocytes .
11337258	0	GlyCAM-1	64,72	glycosylation-dependent_cell_adhesion_molecule_1	14,62	GlyCAM-1	glycosylation-dependent cell adhesion molecule 1	14663(Tax:10090)	14663(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of glycosylation-dependent_cell_adhesion_molecule_1 -LRB- GlyCAM-1 -RRB- gene in the mouse mammary gland differs from that of casein genes .
26200505	0	GlyT1	45,50	BDNF	0,4	GlyT1	BDNF	116509(Tax:10116)	24225(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	BDNF , via truncated TrkB receptor , modulates GlyT1 and GlyT2 in astrocytes .
18709358	0	GlyT1	75,80	glycine_transport_1	43,62	GlyT1	glycine transport 1	116509(Tax:10116)	116509(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Procognitive and antipsychotic efficacy of glycine_transport_1 inhibitors -LRB- GlyT1 -RRB- in acute and neurodevelopmental models of schizophrenia : latent_inhibition studies in the rat .
22542656	0	GlyT1	31,36	glycine_transporter-1	8,29	GlyT1	glycine transporter-1	116509(Tax:10116)	116509(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A novel glycine_transporter-1 -LRB- GlyT1 -RRB- inhibitor , ASP2535 -LRB- 4 - -LSB- 3-isopropyl-5 - -LRB- 6-phenyl-3-pyridyl -RRB- -4 H-1 ,2,4 - triazol-4-yl -RSB- -2,1,3 - benzoxadiazole -RRB- , improves cognition in animal models of cognitive_impairment in schizophrenia and Alzheimer 's _ disease .
22700964	0	GlyT2	17,22	SLC6A5	29,35	GlyT2	SLC6A5	9152	9152	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the GlyT2 gene -LRB- SLC6A5 -RRB- are a second major cause of startle_disease .
20488185	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	Akt	71,74	Glyceraldehyde-3-phosphate dehydrogenase	Akt	24383(Tax:10116)	24185(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle .
23653351	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	GAPDH	42,47	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	2597	2597	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- phosphorylation by protein_kinase_C -LRB- PKC -RRB- inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury .
15485821	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	Rab2	56,60	Glyceraldehyde-3-phosphate dehydrogenase	Rab2	2597	5862	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity .
17553795	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	androgen_receptor	78,95	Glyceraldehyde-3-phosphate dehydrogenase	androgen receptor	2597	367	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase enhances transcriptional activity of androgen_receptor in prostate_cancer cells .
23000033	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	cyclooxygenase-2	51,67	Glyceraldehyde-3-phosphate dehydrogenase	cyclooxygenase-2	14433(Tax:10090)	19225(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability .
18809573	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	endothelin-1	51,63	Glyceraldehyde-3-phosphate dehydrogenase	endothelin-1	2597	1906	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase regulates endothelin-1 expression by a novel , redox-sensitive mechanism involving mRNA stability .
24799178	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	ferredoxin-NADP_reductase	57,82	Glyceraldehyde-3-phosphate dehydrogenase	ferredoxin-NADP reductase	2597	2232	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase is regulated by ferredoxin-NADP_reductase in the diatom Asterionella formosa .
23527007	0	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	mst1	76,80	Glyceraldehyde-3-phosphate dehydrogenase	mst1	2597	4485	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis .
22313865	0	Glycodelin-A	0,12	IL-2R	34,39	Glycodelin-A	IL-2R	5047	3559	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	Glycodelin-A interferes with IL-2 / IL-2R signalling to induce cell growth arrest , loss of effector functions and apoptosis in T-lymphocytes .
22977256	0	Glycodelin-A	0,12	L-selectin	91,101	Glycodelin-A	L-selectin	5047	6402	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Glycodelin-A stimulates interleukin-6 secretion by human monocytes and macrophages through L-selectin and the extracellular signal-regulated kinase pathway .
22977256	0	Glycodelin-A	0,12	interleukin-6	24,37	Glycodelin-A	interleukin-6	5047	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Glycodelin-A stimulates interleukin-6 secretion by human monocytes and macrophages through L-selectin and the extracellular signal-regulated kinase pathway .
26997328	0	Glycogen_Synthase_Kinase-3b	14,41	GSK-3b	43,49	Glycogen Synthase Kinase-3b	GSK-3b	84027(Tax:10116)	84027(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of Glycogen_Synthase_Kinase-3b -LRB- GSK-3b -RRB- as potent therapeutic strategy to ameliorates L-dopa-induced_dyskinesia in 6-OHDA parkinsonian rats .
25334049	0	Glycogen_Synthase_Kinase-3b	73,100	GSK3b	102,107	Glycogen Synthase Kinase-3b	GSK3b	102176363	102176363	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Multiple Alternative Splicing and Differential Expression Pattern of the Glycogen_Synthase_Kinase-3b -LRB- GSK3b -RRB- Gene in Goat -LRB- Capra_hircus -RRB- .
26468894	0	Glycogen_Synthase_Kinase-3b	258,285	Signal_Transducers_and_Activators_of_Transcription-3	161,213	Glycogen Synthase Kinase-3b	Signal Transducers and Activators of Transcription-3	84027(Tax:10116)	25125(Tax:10116)	Gene	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	Remifentanil Preconditioning Reduces Postischemic_Myocardial_Infarction and Improves Left Ventricular Performance via Activation of the Janus_Activated_Kinase-2 / Signal_Transducers_and_Activators_of_Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen_Synthase_Kinase-3b in Rats .
20637111	0	Glycogen_Synthase_Kinase-3beta	0,30	Snail	41,46	Glycogen Synthase Kinase-3beta	Snail	2932	6615	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Glycogen_Synthase_Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric_cancer cells .
25477508	0	Glycogen_Synthase_Kinase_3b	36,63	Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A	75,136	Glycogen Synthase Kinase 3b	Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A	56637(Tax:10090)	13548(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and Inactivation of Glycogen_Synthase_Kinase_3b -LRB- GSK3b -RRB- by Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A -LRB- Dyrk1A -RRB- .
25477508	0	Glycogen_Synthase_Kinase_3b	36,63	GSK3b	65,70	Glycogen Synthase Kinase 3b	GSK3b	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation and Inactivation of Glycogen_Synthase_Kinase_3b -LRB- GSK3b -RRB- by Dual-specificity_Tyrosine_Phosphorylation-regulated_Kinase_1A -LRB- Dyrk1A -RRB- .
18358695	0	Glycogen_synthase	0,17	GYS1	19,23	Glycogen synthase	GYS1	100054723(Tax:9796)	100054723(Tax:9796)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Glycogen_synthase -LRB- GYS1 -RRB- mutation causes a novel skeletal muscle glycogenosis .
23582741	0	Glycogen_synthase_kinase-3_beta	0,31	Snail	42,47	Glycogen synthase kinase-3 beta	Snail	2932	6615	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Glycogen_synthase_kinase-3_beta regulates Snail and b-catenin expression during Fas-induced epithelial-mesenchymal_transition in gastrointestinal_cancer .
12871932	0	Glycogen_synthase_kinase-3_beta	0,31	p105	54,58	Glycogen synthase kinase-3 beta	p105	2932	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Glycogen_synthase_kinase-3_beta regulates NF-kappa_B1 / p105 stability .
23390016	0	Glycogen_synthase_kinase-3b	0,27	GSK3b	29,34	Glycogen synthase kinase-3b	GSK3b	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- expression in a mouse model of Alzheimer 's _ disease : a light and electron microscopy study .
15525785	0	Glycogen_synthase_kinase-3beta	0,30	Bax	46,49	Glycogen synthase kinase-3beta	Bax	2932	581	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Glycogen_synthase_kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis .
17050006	0	Glycogen_synthase_kinase-3beta	0,30	E2F1	40,44	Glycogen synthase kinase-3beta	E2F1	2932	1869	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Glycogen_synthase_kinase-3beta binds to E2F1 and regulates its transcriptional activity .
15731007	0	Glycogen_synthase_kinase-3beta	0,30	MAP1B	50,55	Glycogen synthase kinase-3beta	MAP1B	84027(Tax:10116)	29456(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glycogen_synthase_kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons .
15020233	0	Glycogen_synthase_kinase-3beta	0,30	MEK1	61,65	Glycogen synthase kinase-3beta	MEK1	2932	5604	Gene	Gene	tyrosine-phosphorylated|nsubjpass|START_ENTITY tyrosine-phosphorylated|nmod|END_ENTITY	Glycogen_synthase_kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts .
20599907	0	Glycogen_synthase_kinase-3beta	0,30	TGF-beta1	52,61	Glycogen synthase kinase-3beta	TGF-beta1	2932	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Glycogen_synthase_kinase-3beta negatively regulates TGF-beta1 and Angiotensin_II-mediated cellular activity through interaction with Smad3 .
16288908	0	Glycogen_synthase_kinase-3beta	0,30	beta-catenin	31,43	Glycogen synthase kinase-3beta	beta-catenin	84027(Tax:10116)	84353(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta / beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF , Bcl-2 and survivin expression in rat ischemic preconditioned myocardium .
18615589	0	Glycogen_synthase_kinase-3beta	0,30	beta-catenin	82,94	Glycogen synthase kinase-3beta	beta-catenin	2932	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Glycogen_synthase_kinase-3beta regulates DeltaNp63 gene transcription through the beta-catenin signaling pathway .
15527765	0	Glycogen_synthase_kinase-3beta	0,30	group_IIA_phospholipase_A2	52,78	Glycogen synthase kinase-3beta	group IIA phospholipase A2	2932	5320	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Glycogen_synthase_kinase-3beta negatively regulates group_IIA_phospholipase_A2 expression in human aortic smooth muscle and HepG2 hepatoma cells .
11402035	0	Glycogen_synthase_kinase-3beta	0,30	presenilin_1	41,53	Glycogen synthase kinase-3beta	presenilin 1	2932	5663	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Glycogen_synthase_kinase-3beta regulates presenilin_1 C-terminal fragment levels .
18027881	0	Glycogen_synthase_kinase-3beta	0,30	tumor_necrosis_factor-alpha	42,69	Glycogen synthase kinase-3beta	tumor necrosis factor-alpha	56637(Tax:10090)	21926(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Glycogen_synthase_kinase-3beta suppresses tumor_necrosis_factor-alpha expression in cardiomyocytes during lipopolysaccharide stimulation .
16537926	0	Glycogen_synthase_kinase_3	0,26	paxillin	99,107	Glycogen synthase kinase 3	paxillin	56637(Tax:10090)	19303(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glycogen_synthase_kinase_3 - and extracellular_signal-regulated_kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement .
25031575	0	Glycogen_synthase_kinase_3-b	14,42	GSK3-b	44,50	Glycogen synthase kinase 3-b	GSK3-b	2932	2932	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of Glycogen_synthase_kinase_3-b -LRB- GSK3-b -RRB- gene in azoospermic men .
21674040	0	Glycogen_synthase_kinase_3_beta	0,31	Drosha	77,83	Glycogen synthase kinase 3 beta	Drosha	2932	29102	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Glycogen_synthase_kinase_3_beta -LRB- GSK3b -RRB- phosphorylates the RNAase III enzyme Drosha at S300 and S302 .
24275526	0	Glycogen_synthase_kinase_3_beta	0,31	glial_glutamate_transporter	42,69	Glycogen synthase kinase 3 beta	glial glutamate transporter	84027(Tax:10116)	29483(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Glycogen_synthase_kinase_3_beta regulates glial_glutamate_transporter protein expression in the spinal dorsal horn in rats with neuropathic_pain .
11382772	0	Glycogen_synthase_kinase_3beta	0,30	GATA4	41,46	Glycogen synthase kinase 3beta	GATA4	2932	2626	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Glycogen_synthase_kinase_3beta regulates GATA4 in cardiac myocytes .
10504342	0	Glycogen_synthase_kinase_3beta	0,30	microtubule-associated_protein_1B	50,83	Glycogen synthase kinase 3beta	microtubule-associated protein 1B	2932	4131	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glycogen_synthase_kinase_3beta phosphorylation of microtubule-associated_protein_1B regulates the stability of microtubules in growth cones .
10101009	0	Glycoprotein-340	0,16	surfactant_protein-A	23,43	Glycoprotein-340	surfactant protein-A	1755	653509	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Glycoprotein-340 binds surfactant_protein-A -LRB- SP-A -RRB- and stimulates alveolar macrophage migration in an SP-A-independent manner .
25340554	0	Glycoprotein_130	37,53	IL-6	93,97	Glycoprotein 130	IL-6	3572	3569	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|Cytokines Cytokines|compound|END_ENTITY	The Inhibition of N-Glycosylation of Glycoprotein_130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
25340554	0	Glycoprotein_130	37,53	STAT3	73,78	Glycoprotein 130	STAT3	3572	6774	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	The Inhibition of N-Glycosylation of Glycoprotein_130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
7686151	0	Glycoprotein_330	0,16	lipoprotein_lipase	81,99	Glycoprotein 330	lipoprotein lipase	4036	4023	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Glycoprotein_330 , a member of the low_density_lipoprotein_receptor family , binds lipoprotein_lipase in vitro .
7686151	0	Glycoprotein_330	0,16	low_density_lipoprotein_receptor	34,66	Glycoprotein 330	low density lipoprotein receptor	4036	3949	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Glycoprotein_330 , a member of the low_density_lipoprotein_receptor family , binds lipoprotein_lipase in vitro .
9223502	0	Glycoprotein_D	0,14	HVEM	63,67	Glycoprotein D	HVEM	2532	8764	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Glycoprotein_D of herpes simplex virus -LRB- HSV -RRB- binds directly to HVEM , a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry .
8192431	0	Glyoxalase-I	0,12	GLO	14,17	Glyoxalase-I	GLO	2739	2739	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Glyoxalase-I -LRB- GLO -RRB- polymorphism among two endogamous populations of Andhra Pradesh , India .
24517345	0	Glypican-1	0,10	HGF	42,45	Glypican-1	HGF	14733(Tax:10090)	15234(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism : effect on migration of skeletal muscle precursor cells .
25572615	0	Glypican-3	0,10	ERK	96,99	Glypican-3	ERK	2719	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Glypican-3 promotes epithelial-mesenchymal transition of hepatocellular_carcinoma cells through ERK signaling pathway .
11193214	0	Glypican-3	0,10	GPC3	12,16	Glypican-3	GPC3	2719	2719	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glypican-3 -LRB- GPC3 -RRB- expression in human placenta : localization to the differentiated syncytiotrophoblast .
22751693	0	Glypican-4	0,10	insulin_receptor	63,79	Glypican-4	insulin receptor	2239	3643	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Glypican-4 enhances insulin signaling via interaction with the insulin_receptor and serves as a novel adipokine .
20803547	0	Glypican_3	0,10	GLUT1	20,25	Glypican 3	GLUT1	2719	6513	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Glypican_3 binds to GLUT1 and decreases glucose transport activity in hepatocellular_carcinoma cells .
17350117	0	Glypican_3	37,47	GPC3	49,53	Glypican 3	GPC3	2719	2719	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	In vivo footprinting analysis of the Glypican_3 -LRB- GPC3 -RRB- promoter region in neuroblastoma cells .
12602503	0	Glyt-1	54,60	glycine_transporter	33,52	Glyt-1	glycine transporter	116509(Tax:10116)	116509(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of astrocytic glycine_transporter -LRB- Glyt-1 -RRB- in acute_liver_failure .
26615201	0	Gm15055	23,30	Hoxa	41,45	Gm15055	Hoxa	102635415	111336(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster .
7713516	0	Gm2a	51,55	GM2	28,31	Gm2a	GM2	14667(Tax:10090)	192986(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The mouse gene encoding the GM2 activator protein -LRB- Gm2a -RRB- : cDNA sequence , expression , and chromosome mapping .
22195028	0	GmFT2a	0,6	FLOWERING_LOCUS_T	29,46	GmFT2a	FLOWERING LOCUS T	100814951	100814951	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	GmFT2a , a soybean homolog of FLOWERING_LOCUS_T , is involved in flowering transition and maintenance .
322999	0	Gn-RH	44,49	gonadotrophin-releasing_hormone	11,42	Gn-RH	gonadotrophin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of gonadotrophin-releasing_hormone -LRB- Gn-RH -RRB- from isolated , perifused medial-basal hypothalamus by melatonin .
6815258	0	Gn-RH	125,130	gonadotropin-releasing-hormone	93,123	Gn-RH	gonadotropin-releasing-hormone	2796	2796	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Induction of ovulation and pregnancy resulting from chronic and pulsatile administration of gonadotropin-releasing-hormone -LRB- Gn-RH -RRB- -RSB- .
6754523	0	Gn-RH	58,63	gonadotropin-releasing_hormone	26,56	Gn-RH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Pulsatile treatment with gonadotropin-releasing_hormone -LRB- Gn-RH -RRB- -RSB- .
2699145	0	Gn-RH	44,49	gonadotropin_releasing_hormone	12,42	Gn-RH	gonadotropin releasing hormone	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of gonadotropin_releasing_hormone -LRB- Gn-RH -RRB- in the regulation of gonadal functions of birds .
25729962	0	GnIH	102,106	gonadotropin-inhibitory_hormone	69,100	GnIH	gonadotropin-inhibitory hormone	378785(Tax:9031)	378785(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and association of single-nucleotide polymorphisms in gonadotropin-inhibitory_hormone -LRB- GnIH -RRB- gene with egg production traits in Erlang mountainous chickens .
21755670	0	GnIH	60,64	kisspeptin	12,22	GnIH	kisspeptin	100127217(Tax:9940)	101107719	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of kisspeptin and gonadotropin_inhibitory_hormone -LRB- GnIH -RRB- in the seasonality of reproduction in sheep .
15233743	0	GnRH	74,78	BDNF	24,28	GnRH	BDNF	2796	627	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Neurotrophic effects of BDNF on embryonic gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons .
10537130	0	GnRH	61,65	ERalpha	111,118	GnRH	ERalpha	25194(Tax:10116)	24890(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
12065890	0	GnRH	121,125	GnRH	138,142	GnRH	GnRH	2796	2796	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by GnRH neurons .
12065890	0	GnRH	138,142	GnRH	121,125	GnRH	GnRH	2796	2796	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by GnRH neurons .
6097437	0	GnRH	21,25	GnRH	49,53	GnRH	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Increases in ovarian GnRH receptors by following GnRH treatment .
6097437	0	GnRH	49,53	GnRH	21,25	GnRH	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Increases in ovarian GnRH receptors by following GnRH treatment .
7628409	0	GnRH	10,14	GnRH	27,31	GnRH	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Increased GnRH mRNA in the GnRH neurons expressing cFos during the proestrous LH surge .
7628409	0	GnRH	27,31	GnRH	10,14	GnRH	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Increased GnRH mRNA in the GnRH neurons expressing cFos during the proestrous LH surge .
11399483	0	GnRH	18,22	GnRH-II	35,42	GnRH	GnRH-II	2796	426561(Tax:9031)	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of salmon GnRH and chicken GnRH-II on testicular apoptosis in goldfish -LRB- Carassius_auratus -RRB- .
7873095	0	GnRH	45,49	GnRH-II	95,102	GnRH	GnRH-II	2796	426561(Tax:9031)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Immunocytochemical localization of mammalian GnRH -LRB- gonadotropin-releasing_hormone -RRB- and chicken GnRH-II in the brain of the European silver eel -LRB- Anguilla_anguilla L. -RRB- .
8288771	0	GnRH	38,42	GnRH-II	89,96	GnRH	GnRH-II	2796	426561(Tax:9031)	Gene	Gene	distribution|nmod|START_ENTITY END_ENTITY|nsubj|distribution	Comparative distribution of mammalian GnRH -LRB- gonadotrophin-releasing hormone -RRB- and chicken GnRH-II in the brain of the immature Siberian_sturgeon -LRB- Acipenser_baeri -RRB- .
9389550	0	GnRH	49,53	GnRH-II	87,94	GnRH	GnRH-II	613033(Tax:9544)	426561(Tax:9031)	Gene	Gene	gonadotropin-releasing_hormone|appos|START_ENTITY gonadotropin-releasing_hormone|nmod|characteristics characteristics|nmod|END_ENTITY	A second form of gonadotropin-releasing_hormone -LRB- GnRH -RRB- with characteristics of chicken GnRH-II is present in the primate brain .
17474316	0	GnRH	38,42	GnRH-R	62,68	GnRH	GnRH-R	2796	2798	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Effect of stress on the expression of GnRH and GnRH_receptor -LRB- GnRH-R -RRB- genes in the preoptic area-hypothalamus and GnRH-R gene in the stalk/median eminence and anterior pituitary gland in ewes during follicular phase of the estrous cycle .
7563392	0	GnRH	51,55	GnRH_receptor	85,98	GnRH	GnRH receptor	25194(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Stage specific identification of the expression of GnRH mRNA and localization of the GnRH_receptor in mature rat and adult human testis .
15492280	0	GnRH	32,36	Gonadotropin-releasing_hormone	0,30	GnRH	Gonadotropin-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists promote proapoptotic signaling in peripheral reproductive_tumor cells by activating a Galphai-coupling state of the type I GnRH_receptor .
16712461	0	GnRH	32,36	Gonadotropin-releasing_hormone	0,30	GnRH	Gonadotropin-releasing hormone	2796	2796	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors in tumors : a new rationale for the therapeutical application of GnRH analogs in cancer patients ?
3123511	0	GnRH	32,36	Gonadotropin-releasing_hormone	0,30	GnRH	Gonadotropin-releasing hormone	2796	2796	Gene	Gene	suppression|appos|START_ENTITY suppression|amod|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- analog suppression renders polycystic_ovarian_disease patients more susceptible to ovulation induction with pulsatile GnRH .
9088896	0	GnRH	32,36	Gonadotropin-releasing_hormone	0,30	GnRH	Gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- content in the median eminence after superior cervical ganglionectomy in ovariectomized and estrogen-treated rats .
17192702	0	GnRH	17,21	Orexin_A	0,8	GnRH	Orexin A	25194(Tax:10116)	25723(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Orexin_A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons .
12151779	0	GnRH	21,25	Orphanin_FQ	0,11	GnRH	Orphanin FQ	25194(Tax:10116)	25516(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Orphanin_FQ inhibits GnRH secretion from rat hypothalamic fragments but not GT1-7 neurons .
9150700	0	GnRH	99,103	Prostate_specific_antigen	0,25	GnRH	Prostate specific antigen	2796	354	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Prostate_specific_antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment .
18466765	0	GnRH	30,34	adiponectin	9,20	GnRH	adiponectin	2796	9370	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential .
11160843	0	GnRH	60,64	annexin_V	15,24	GnRH	annexin V	2796	308	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of annexin_V in the antiproliferative effect of GnRH agonist on cultured human uterine leiomyoma cells .
10848876	0	GnRH	43,47	gonadotrophin-releasing_hormone	10,41	GnRH	gonadotrophin-releasing hormone	2796	2796	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- antagonist during the LH surge in normal women and during controlled ovarian_hyperstimulation .
18563864	0	GnRH	69,73	gonadotrophin-releasing_hormone	36,67	GnRH	gonadotrophin-releasing hormone	2796	2796	Gene	Gene	determination|appos|START_ENTITY determination|nmod|END_ENTITY	Mass spectrometric determination of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- in human urine for doping control purposes by means of LC-ESI-MS/MS .
20814074	0	GnRH	114,118	gonadotrophin-releasing_hormone	81,112	GnRH	gonadotrophin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Vasopressin release from the rat hypothalamo-neurohypophysial system : effects of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- , its analogues and melatonin .
10513982	1	GnRH	115,119	gonadotropin-releasing_hormone	83,113	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation with gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist-induced apoptosis in the corpus luteum .
10537130	0	GnRH	61,65	gonadotropin-releasing_hormone	29,59	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
10551782	0	GnRH	79,83	gonadotropin-releasing_hormone	47,77	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Enhanced splicing of the first intron from the gonadotropin-releasing_hormone -LRB- GnRH -RRB- primary transcript is a prerequisite for mature GnRH messenger RNA : presence of GnRH neuron-specific splicing factors .
1097462	0	GnRH	52,56	gonadotropin-releasing_hormone	20,50	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of synthetic gonadotropin-releasing_hormone -LRB- GnRH -RRB- in a patient with the `` fertile_eunuch '' _ syndrome .
11223187	0	GnRH	83,87	gonadotropin-releasing_hormone	51,81	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of exonic splicing enhancers in the mouse gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene .
11245923	0	GnRH	132,136	gonadotropin-releasing_hormone	100,130	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A functional retinoic_acid response element -LRB- RARE -RRB- is present within the distal promoter of the rat gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene .
11245924	0	GnRH	83,87	gonadotropin-releasing_hormone	51,81	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	9-cis-Retinoic_acid represses transcription of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene via proximal promoter region that is distinct from all-trans-retinoic_acid response element .
11255560	0	GnRH	94,98	gonadotropin-releasing_hormone	62,92	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Progress towards the development of non-peptide orally-active gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists : therapeutic implications .
11307033	0	GnRH	46,50	gonadotropin-releasing_hormone	14,44	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression during GnRH neuron migration in the mouse .
11312152	0	GnRH	54,58	gonadotropin-releasing_hormone	22,52	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Autoregulation of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- system during puberty : effects of antagonistic versus agonistic GnRH analogs in a female rat model .
12065890	0	GnRH	138,142	gonadotropin-releasing_hormone	89,119	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by GnRH neurons .
12639969	0	GnRH	70,74	gonadotropin-releasing_hormone	38,68	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Excision of the first intron from the gonadotropin-releasing_hormone -LRB- GnRH -RRB- transcript serves as a key regulatory step for GnRH biosynthesis .
12865313	0	GnRH	87,91	gonadotropin-releasing_hormone	55,85	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sex differences in estrogen-dependent transcription of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene revealed in GnRH transgenic_mice .
12865349	0	GnRH	63,67	gonadotropin-releasing_hormone	31,61	GnRH	gonadotropin-releasing hormone	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Seasonal plasticity within the gonadotropin-releasing_hormone -LRB- GnRH -RRB- system of the ewe : changes in identified GnRH inputs and glial association .
1374022	0	GnRH	64,68	gonadotropin-releasing_hormone	32,62	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Partial characterization of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene transcript in the rat ovary .
14525953	0	GnRH	127,131	gonadotropin-releasing_hormone	95,125	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Position of Pro and Ser near Glu7 .32 in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II .
14594454	0	GnRH	40,44	gonadotropin-releasing_hormone	8,38	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in ovarian_cancer .
15004428	0	GnRH	46,50	gonadotropin-releasing_hormone	14,44	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Repression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression by melatonin may involve transcription factors COUP-TFI and C/EBP _ beta binding at the GnRH enhancer .
16412770	0	GnRH	47,51	gonadotropin-releasing_hormone	15,45	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Treatment with gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists in women suppressed with GnRH agonist may avoid cycle cancellation in patients at risk for ovarian_hyperstimulation_syndrome .
1657576	0	GnRH	84,88	gonadotropin-releasing_hormone	52,82	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Protein_kinase-C activation stimulates synthesis of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors , but does not mediate GnRH-stimulated receptor synthesis .
16675899	0	GnRH	88,92	gonadotropin-releasing_hormone	56,86	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Photoperiod-independent changes in immunoreactive brain gonadotropin-releasing_hormone -LRB- GnRH -RRB- in a free-living , tropical bird .
16929534	0	GnRH	40,44	gonadotropin-releasing_hormone	8,38	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the regulation of gonadal differentiation in the gilthead seabream -LRB- Sparus aurata -RRB- .
17852411	0	GnRH	85,89	gonadotropin-releasing_hormone	53,83	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Controlled ovarian_hyperstimulation using multi-dose gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist results in less systemic_inflammation than the GnRH-agonist long protocol .
18423456	0	GnRH	50,54	gonadotropin-releasing_hormone	18,48	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Pretreatment with gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists to prevent the flare-up effect of long-acting GnRH agonists : results of a pilot study .
19040620	0	GnRH	72,76	gonadotropin-releasing_hormone	40,70	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dihydrotestosterone and leptin regulate gonadotropin-releasing_hormone -LRB- GnRH -RRB- expression and secretion in human GnRH-secreting neuroblasts .
19856133	0	GnRH	59,63	gonadotropin-releasing_hormone	27,57	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in pancreas during rat pregnancy .
19861704	0	GnRH	46,50	gonadotropin-releasing_hormone	14,44	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptor-I expression in the pituitary and ovary by a GnRH agonist and antagonist .
21660456	0	GnRH	65,69	gonadotropin-releasing_hormone	33,63	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Histological characterization of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the hypothalamus of the South American plains vizcacha -LRB- Lagostomus maximus -RRB- .
21924414	0	GnRH	213,217	gonadotropin-releasing_hormone	181,211	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Is earlier administration of human chorionic gonadotropin -LRB- hCG -RRB- associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists ?
2274018	0	GnRH	58,62	gonadotropin-releasing_hormone	26,56	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Pulsatile treatment with gonadotropin-releasing_hormone -LRB- GnRH -RRB- -RSB- .
2500326	0	GnRH	183,187	gonadotropin-releasing_hormone	151,181	GnRH	gonadotropin-releasing hormone	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Bilateral orchidectomy and concomitant testosterone replacement in the juvenile male rhesus_monkey -LRB- Macaca_mulatta -RRB- receiving an invariant intravenous gonadotropin-releasing_hormone -LRB- GnRH -RRB- infusion results , as in the hypothalamus lesioned GnRH-driven adult male , in a selective hypersecretion of follicle-stimulating hormone .
2501122	0	GnRH	55,59	gonadotropin-releasing_hormone	23,53	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Simultaneous effect of gonadotropin-releasing_hormone -LRB- GnRH -RRB- on the expression of two gonadotropin beta genes by passive immunization to GnRH .
2513450	0	GnRH	50,54	gonadotropin-releasing_hormone	18,48	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Regulation of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal system : morphological aspects .
2546961	0	GnRH	56,60	gonadotropin-releasing_hormone	24,54	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Normal structure of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene in patients with GnRH_deficiency and idiopathic_hypogonadotropic_hypogonadism .
25516463	0	GnRH	79,83	gonadotropin-releasing_hormone	47,77	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Autoshortloop feedback regulation of pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion by its metabolite , GnRH - -LRB- 1-5 -RRB- .
2987065	0	GnRH	72,76	gonadotropin-releasing_hormone	40,70	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Newborn and immature rat testes contain gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors , and their testosterone production is stimulated by a GnRH agonist in vitro .
3098547	0	GnRH	63,67	gonadotropin-releasing_hormone	31,61	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Reevaluation of immunoreactive gonadotropin-releasing_hormone -LRB- GnRH -RRB- levels in general circulation in women : changes in levels and episodic patterns before , during and after gonadotropin surges .
322467	0	GnRH	68,72	gonadotropin-releasing_hormone	36,66	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the fetal and early postnatal mouse brain .
3287358	0	GnRH	56,60	gonadotropin-releasing_hormone	24,54	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Polygenic expression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in human ?
3539214	0	GnRH	93,97	gonadotropin-releasing_hormone	61,91	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Short photoperiod-induced gonadal_regression : effects on the gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal system of the white-footed mouse , Peromyscus leucopus .
3920237	0	GnRH	52,56	gonadotropin-releasing_hormone	20,50	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Hormonal effects of gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist in the human male .
6363435	0	GnRH	56,60	gonadotropin-releasing_hormone	24,54	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of continuous gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist treatment on luteinizing hormone and testosterone secretion , the response to GnRH , and the testicular response to human chorionic gonadotropin in male rhesus_monkeys .
6369267	0	GnRH	59,63	gonadotropin-releasing_hormone	27,57	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Proteolytic degradation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- by rat ovarian fractions in vitro .
7013981	0	GnRH	68,72	gonadotropin-releasing_hormone	36,66	GnRH	gonadotropin-releasing hormone	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the brain and infundibulum of the sheep .
7858734	0	GnRH	54,58	gonadotropin-releasing_hormone	22,52	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Stimulatory effect of gonadotropin-releasing_hormone -LRB- GnRH -RRB- on in vitro prolactin secretion and presence of GnRH specific receptors in a subset of human prolactinomas .
8137746	0	GnRH	64,68	gonadotropin-releasing_hormone	32,62	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Central regulation of pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion by estradiol during the period leading up to the preovulatory GnRH surge in the ewe .
8187165	0	GnRH	43,47	gonadotropin-releasing_hormone	11,41	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of gonadotropin-releasing_hormone -LRB- GnRH -RRB- on the cytodifferentiation of gonadotropes in rat adenohypophysial primordia in organ culture .
8300908	0	GnRH	78,82	gonadotropin-releasing_hormone	46,76	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and morphology of immunoreactive gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons in the basal forebrain of ponies .
8405686	0	GnRH	104,108	gonadotropin-releasing_hormone	72,102	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Biochemical differentiation and intercellular interactions of migratory gonadotropin-releasing_hormone -LRB- GnRH -RRB- cells in the mouse .
8721988	0	GnRH	54,58	gonadotropin-releasing_hormone	22,52	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Steroid and pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- regulation of luteinizing hormone and GnRH_receptor in a novel gonadotrope cell line .
8732461	0	GnRH	58,62	gonadotropin-releasing_hormone	26,56	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Continuous stimulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors by GnRH agonist decreases pituitary GnRH_receptor messenger ribonucleic_acid concentration in immature female rats .
9048632	0	GnRH	72,76	gonadotropin-releasing_hormone	40,70	GnRH	gonadotropin-releasing hormone	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Evidence for seasonal plasticity in the gonadotropin-releasing_hormone -LRB- GnRH -RRB- system of the ewe : changes in synaptic inputs onto GnRH neurons .
9121495	0	GnRH	64,68	gonadotropin-releasing_hormone	32,62	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Phorbol_ester regulation of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene in GnRH-secreting cell lines : a molecular basis for species differences .
9158062	0	GnRH	47,51	gonadotropin-releasing_hormone	15,45	GnRH	gonadotropin-releasing hormone	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	On the role of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the operation of the GnRH pulse generator in the rhesus_monkey .
9212061	0	GnRH	46,50	gonadotropin-releasing_hormone	14,44	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression by insulin-like_growth_factor_I in a cultured GnRH-expressing neuronal cell line .
9389763	0	GnRH	82,86	gonadotropin-releasing_hormone	50,80	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Cytochemical studies of the effects of activin on gonadotropin-releasing_hormone -LRB- GnRH -RRB- binding by pituitary gonadotropes and growth_hormone cells .
9406917	0	GnRH	69,73	gonadotropin-releasing_hormone	37,67	GnRH	gonadotropin-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence for autocrine inhibition of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene transcription by GnRH in hypothalamic GT1-1 neuronal cells .
9435376	0	GnRH	89,93	gonadotropin-releasing_hormone	57,87	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Regulation of follicular luteinization by an agonist of gonadotropin-releasing_hormone -LRB- GnRH -RRB- -RSB- .
9528988	0	GnRH	62,66	gonadotropin-releasing_hormone	30,60	GnRH	gonadotropin-releasing hormone	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Neonatal immunization against gonadotropin-releasing_hormone -LRB- GnRH -RRB- results in diminished GnRH secretion in adulthood .
9556083	0	GnRH	52,56	gonadotropin-releasing_hormone	58,88	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	identification|nmod|START_ENTITY identification|dep|END_ENTITY	Chromatographic and immunological identification of GnRH -LRB- gonadotropin-releasing_hormone -RRB- variants .
9688346	0	GnRH	44,48	gonadotropin-releasing_hormone	12,42	GnRH	gonadotropin-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Presence of gonadotropin-releasing_hormone -LRB- GnRH -RRB- mRNA in Rathke 's pouch and effect of the GnRH-antagonist ORG_30276 on lactotroph development in vitro .
9739116	0	GnRH	44,48	gonadotropin-releasing_hormone	12,42	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increase in gonadotropin-releasing_hormone -LRB- GnRH -RRB- levels in CSF after stimulation of the nervus terminalis in Atlantic stingray , Dasyatis sabina .
9783851	0	GnRH	46,50	gonadotropin-releasing_hormone	14,44	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene in human uterine endometrial tissue .
9915990	0	GnRH	57,61	gonadotropin-releasing_hormone	25,55	GnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Photoperiodic effects on gonadotropin-releasing_hormone -LRB- GnRH -RRB- content and the GnRH-immunoreactive neuronal system of male Siberian hamsters .
6427062	0	GnRH	66,70	gonadotropin-releasing_hormones	33,64	GnRH	gonadotropin-releasing hormones	2796	2796	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of chicken and mammalian gonadotropin-releasing_hormones -LRB- GnRH -RRB- on in vivo pituitary gonadotropin release in amphibians and reptiles .
10937733	0	GnRH	46,50	gonadotropin_releasing_hormone	14,44	GnRH	gonadotropin releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Quinolones as gonadotropin_releasing_hormone -LRB- GnRH -RRB- antagonists : simultaneous optimization of the C -LRB- 3 -RRB- - aryl and C -LRB- 6 -RRB- - substituents .
3030856	0	GnRH	59,63	gonadotropin_releasing_hormone	27,57	GnRH	gonadotropin releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Blockade of rat testicular gonadotropin_releasing_hormone -LRB- GnRH -RRB- receptors by infusion of a GnRH antagonist has no major effects of Leydig cell function in vivo .
19616057	0	GnRH	33,37	mPer1	13,18	GnRH	mPer1	2796	18626(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of mPer1 expression by GnRH in pituitary gonadotrope cells involves EGR-1 .
10499517	0	GnRH	168,172	prolyl_endopeptidase	132,152	GnRH	prolyl endopeptidase	25194(Tax:10116)	83471(Tax:10116)	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Early prepubertal ontogeny of pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion : I. Inhibitory autofeedback control through prolyl_endopeptidase degradation of GnRH .
15277720	0	GnRH	48,52	type_II_GnRH_receptor	6,27	GnRH	type II GnRH receptor	2796	114814	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Human type_II_GnRH_receptor mediates effects of GnRH on cell proliferation .
16183188	0	GnRH	88,92	vascular_endothelial_growth_factor	17,51	GnRH	vascular endothelial growth factor	2796	7422	Gene	Gene	cycles|amod|START_ENTITY increased|nmod|cycles increased|nsubjpass|concentrations concentrations|compound|END_ENTITY	Follicular fluid vascular_endothelial_growth_factor concentrations are increased during GnRH antagonist/FSH ovarian stimulation cycles .
18321491	0	GnRH	61,65	vascular_endothelial_growth_factor	8,42	GnRH	vascular endothelial growth factor	2796	7422	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Altered vascular_endothelial_growth_factor expression during GnRH antagonist protocol in women of reproductive age with normal baseline hormone profiles .
21872303	0	GnRH-I	64,70	gonadotropin_releasing_hormone-I	30,62	GnRH-I	gonadotropin releasing hormone-I	770134(Tax:9031)	770134(Tax:9031)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and variation in gonadotropin_releasing_hormone-I -LRB- GnRH-I -RRB- immunoreactive neurons in the brain of the native Thai chicken during the reproductive cycle .
11399483	0	GnRH-II	35,42	GnRH	18,22	GnRH-II	GnRH	426561(Tax:9031)	2796	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of salmon GnRH and chicken GnRH-II on testicular apoptosis in goldfish -LRB- Carassius_auratus -RRB- .
7873095	0	GnRH-II	95,102	GnRH	45,49	GnRH-II	GnRH	426561(Tax:9031)	2796	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Immunocytochemical localization of mammalian GnRH -LRB- gonadotropin-releasing_hormone -RRB- and chicken GnRH-II in the brain of the European silver eel -LRB- Anguilla_anguilla L. -RRB- .
8288771	0	GnRH-II	89,96	GnRH	38,42	GnRH-II	GnRH	426561(Tax:9031)	2796	Gene	Gene	START_ENTITY|nsubj|distribution distribution|nmod|END_ENTITY	Comparative distribution of mammalian GnRH -LRB- gonadotrophin-releasing hormone -RRB- and chicken GnRH-II in the brain of the immature Siberian_sturgeon -LRB- Acipenser_baeri -RRB- .
9389550	0	GnRH-II	87,94	GnRH	49,53	GnRH-II	GnRH	426561(Tax:9031)	613033(Tax:9544)	Gene	Gene	characteristics|nmod|START_ENTITY gonadotropin-releasing_hormone|nmod|characteristics gonadotropin-releasing_hormone|appos|END_ENTITY	A second form of gonadotropin-releasing_hormone -LRB- GnRH -RRB- with characteristics of chicken GnRH-II is present in the primate brain .
11889221	0	GnRH-II	49,56	gonadotropin-releasing_hormone_II	14,47	GnRH-II	gonadotropin-releasing hormone II	2797	2797	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Expression of gonadotropin-releasing_hormone_II -LRB- GnRH-II -RRB- receptor in human endometrial_and_ovarian_cancer cells and effects of GnRH-II on tumor cell proliferation .
17474316	0	GnRH-R	62,68	GnRH	38,42	GnRH-R	GnRH	2798	2796	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Effect of stress on the expression of GnRH and GnRH_receptor -LRB- GnRH-R -RRB- genes in the preoptic area-hypothalamus and GnRH-R gene in the stalk/median eminence and anterior pituitary gland in ewes during follicular phase of the estrous cycle .
17945441	0	GnRH-R	42,48	GnRH_receptor	27,40	GnRH-R	GnRH receptor	2798	2798	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Expression of the GnRH and GnRH_receptor -LRB- GnRH-R -RRB- genes in the hypothalamus and of the GnRH-R gene in the anterior pituitary gland of anestrous and luteal phase ewes .
17973212	0	GnRH-R	100,106	GnRH_receptor	85,98	GnRH-R	GnRH receptor	2798	2798	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The central effect of beta-endorphin and naloxone on the expression of GnRH Gene and GnRH_receptor -LRB- GnRH-R -RRB- gene in the hypothalamus , and on GnRH-R gene in the anterior pituitary gland in follicular phase ewes .
18434046	0	GnRH-R	89,95	GnRH_receptor	74,87	GnRH-R	GnRH receptor	2798	2798	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of GABA -LRB- A -RRB- receptor modulation on the expression of GnRH gene and GnRH_receptor -LRB- GnRH-R -RRB- gene in the hypothalamus and GnRH-R gene in the anterior pituitary gland of follicular-phase ewes .
7492677	1	GnRH-R	141,147	GnRH_receptor	126,139	GnRH-R	GnRH receptor	2798	2798	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Characterization of changes in GnRH_receptor -LRB- GnRH-R -RRB- , c-fos , and c-jun messenger ribonucleic acids during the ovine estrous cycle .
27101301	0	GnRH-R	56,62	LepR	48,52	GnRH-R	LepR	14715(Tax:10090)	16847(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Leptin_receptor null mice with re-expression of LepR in GnRH-R expressing cells display elevated FSH levels but remain in a prepubertal state .
7557974	0	GnRH-R	74,80	gonadotropin-releasing_hormone_receptor	33,72	GnRH-R	gonadotropin-releasing hormone receptor	2798	2798	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Subregional mapping of the human gonadotropin-releasing_hormone_receptor -LRB- GnRH-R -RRB- gene to 4q between the markers D4S392 and D4S409 .
24472523	0	GnRHR	50,55	gonadotropin-releasing_hormone_receptor	9,48	GnRHR	gonadotropin-releasing hormone receptor	2798	2798	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Aberrant gonadotropin-releasing_hormone_receptor -LRB- GnRHR -RRB- expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma -LRB- APA -RRB- .
21104139	0	GnRHR	89,94	gonadotropin_releasing_hormone_receptor	48,87	GnRHR	gonadotropin releasing hormone receptor	281798(Tax:9913)	281798(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effects of MboII and BspMI polymorphisms in the gonadotropin_releasing_hormone_receptor -LRB- GnRHR -RRB- gene on sperm quality in Holstein bulls .
20543462	0	GnRH_II	10,17	VEGF	45,49	GnRH II	VEGF	2797	7422	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of GnRH_II and GnRH_I on secretion of VEGF by eutopic and ectopic endometrial stromal cells of endometriosis patients .
7563392	0	GnRH_receptor	85,98	GnRH	51,55	GnRH receptor	GnRH	81668(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stage specific identification of the expression of GnRH mRNA and localization of the GnRH_receptor in mature rat and adult human testis .
17945441	0	GnRH_receptor	27,40	GnRH-R	42,48	GnRH receptor	GnRH-R	2798	2798	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Expression of the GnRH and GnRH_receptor -LRB- GnRH-R -RRB- genes in the hypothalamus and of the GnRH-R gene in the anterior pituitary gland of anestrous and luteal phase ewes .
17973212	0	GnRH_receptor	85,98	GnRH-R	100,106	GnRH receptor	GnRH-R	2798	2798	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The central effect of beta-endorphin and naloxone on the expression of GnRH Gene and GnRH_receptor -LRB- GnRH-R -RRB- gene in the hypothalamus , and on GnRH-R gene in the anterior pituitary gland in follicular phase ewes .
18434046	0	GnRH_receptor	74,87	GnRH-R	89,95	GnRH receptor	GnRH-R	2798	2798	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of GABA -LRB- A -RRB- receptor modulation on the expression of GnRH gene and GnRH_receptor -LRB- GnRH-R -RRB- gene in the hypothalamus and GnRH-R gene in the anterior pituitary gland of follicular-phase ewes .
7492677	1	GnRH_receptor	126,139	GnRH-R	141,147	GnRH receptor	GnRH-R	2798	2798	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Characterization of changes in GnRH_receptor -LRB- GnRH-R -RRB- , c-fos , and c-jun messenger ribonucleic acids during the ovine estrous cycle .
18760324	0	GnRH_receptor	38,51	NeuroD1	0,7	GnRH receptor	NeuroD1	14715(Tax:10090)	18012(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	NeuroD1 and Mash1 temporally regulate GnRH_receptor gene expression in immortalized mouse gonadotrope cells .
7492677	1	GnRH_receptor	126,139	c-fos	150,155	GnRH receptor	c-fos	2798	2353	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Characterization of changes in GnRH_receptor -LRB- GnRH-R -RRB- , c-fos , and c-jun messenger ribonucleic acids during the ovine estrous cycle .
16434023	0	GnT-IVa_and_b	68,81	N-acetylglucosaminyltransferase-IVa_and_IVb	23,66	GnT-IVa and b	N-acetylglucosaminyltransferase-IVa and IVb	11320	11320;11282	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Aberrant expression of N-acetylglucosaminyltransferase-IVa_and_IVb -LRB- GnT-IVa_and_b -RRB- in pancreatic_cancer .
21771782	0	GnT-IX	65,71	N-acetylglucosaminyltransferase_IX	29,63	GnT-IX	N-acetylglucosaminyltransferase IX	146664	146664	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Brain-specific expression of N-acetylglucosaminyltransferase_IX -LRB- GnT-IX -RRB- is regulated by epigenetic histone modifications .
24619417	0	GnT-IX	98,104	glycosyltransferase_N-acetylglucosaminyltransferase-IX	42,96	GnT-IX	glycosyltransferase N-acetylglucosaminyltransferase-IX	268510(Tax:10090)	268510(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of a brain-specific glycosyltransferase_N-acetylglucosaminyltransferase-IX -LRB- GnT-IX -RRB- by specific chromatin modifiers .
10438459	0	GnT-V	18,23	Ets-1	57,62	GnT-V	Ets-1	4249	2113	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the GnT-V promoter by transcription factor Ets-1 in various cancer cell lines .
25524127	0	GnT-V	61,66	N-acetylglucosaminyltransferase_V	26,59	GnT-V	N-acetylglucosaminyltransferase V	107895(Tax:10090)	107895(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Predominant expression of N-acetylglucosaminyltransferase_V -LRB- GnT-V -RRB- in neural stem/progenitor cells .
11455198	0	Go	55,57	GTP-binding_protein	34,53	Go	GTP-binding protein	280872(Tax:9913)	280872(Tax:9913)	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association of heterotrimeric GTP-binding_protein -LRB- Go -RRB- with microtubules .
8095554	0	Go_alpha	77,85	GTP-binding_protein	86,105	Go alpha	GTP-binding protein	14681(Tax:10090)	59021(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	D2-dopaminergic agonist quinpirole and 8-bromo-cAMP have opposite effects on Go_alpha GTP-binding_protein mRNA without changing D2 dopamine receptor mRNA levels in striatal neurones in primary culture .
26232767	0	GolS	51,55	galactinol_synthase	30,49	GolS	galactinol synthase	100316891(Tax:4081)	100316891(Tax:4081)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Genome-wide identification of galactinol_synthase -LRB- GolS -RRB- genes in Solanum_lycopersicum and Brachypodium_distachyon .
26232767	0	GolS	51,55	galactinol_synthase	30,49	GolS	galactinol synthase	100316891(Tax:4081)	100316891(Tax:4081)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Genome-wide identification of galactinol_synthase -LRB- GolS -RRB- genes in Solanum_lycopersicum and Brachypodium_distachyon .
20660722	0	Golgi-associated_retrograde_protein	79,114	GARP	116,120	Golgi-associated retrograde protein	GARP	2615	2615	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated_retrograde_protein -LRB- GARP -RRB- complex to a family of tethering complexes .
18063581	0	Golgi-specific_brefeldin_A_resistance_factor_1	44,90	AMP-activated_protein_kinase	0,28	Golgi-specific brefeldin A resistance factor 1	AMP-activated protein kinase	8729	5563	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	AMP-activated_protein_kinase phosphorylates Golgi-specific_brefeldin_A_resistance_factor_1 at Thr1337 to induce disassembly of Golgi apparatus .
24357227	0	Golgi_pH_regulator	55,73	GPHR	75,79	Golgi pH regulator	GPHR	36682(Tax:7227)	36682(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Mutations in the Drosophila ortholog of the vertebrate Golgi_pH_regulator -LRB- GPHR -RRB- protein disturb endoplasmic reticulum and Golgi organization and affect systemic growth .
19291786	0	Golgi_phosphoprotein_2	0,22	GOLPH2	24,30	Golgi phosphoprotein 2	GOLPH2	51280	51280	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Golgi_phosphoprotein_2 -LRB- GOLPH2 -RRB- expression in liver_tumors and its value as a serum marker in hepatocellular_carcinomas .
25218347	0	Golgi_phosphoprotein_3	75,97	Protein_kinase_D2	0,17	Golgi phosphoprotein 3	Protein kinase D2	64083	25865	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Protein_kinase_D2 promotes the proliferation of glioma cells by regulating Golgi_phosphoprotein_3 .
25938831	0	Golgi_protein-73	27,43	GP73	45,49	Golgi protein-73	GP73	51280	51280	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	-LSB- Diagnostic value of serum Golgi_protein-73 -LRB- GP73 -RRB- combined with AFP-L3 % in hepatocellular_carcinoma : a meta-analysis -RSB- .
26378022	0	Golgi_protein_73	0,16	MMP-13	31,37	Golgi protein 73	MMP-13	51280	4322	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Golgi_protein_73 activation of MMP-13 promotes hepatocellular_carcinoma cell invasion .
12656988	0	Golgin-84	0,9	rab1	15,19	Golgin-84	rab1	9950	5861	Gene	Gene	partner|nsubj|START_ENTITY partner|amod|END_ENTITY	Golgin-84 is a rab1 binding partner involved in Golgi structure .
22235371	0	Gonadotropin-Releasing_Hormone	129,159	ERK	39,42	Gonadotropin-Releasing Hormone	ERK	2796	5594	Gene	Gene	Induction|nmod|START_ENTITY Induction|nsubj|Activation Activation|appos|END_ENTITY	Extracellular_Signal-Regulated_Kinase -LRB- ERK -RRB- Activation and Mitogen-Activated_Protein_Kinase_Phosphatase_1 Induction by Pulsatile Gonadotropin-Releasing_Hormone in Pituitary Gonadotrophs .
26644469	0	Gonadotropin-Releasing_Hormone	24,54	ERK	112,115	Gonadotropin-Releasing Hormone	ERK	2796	5594	Gene	Gene	Signaling|compound|START_ENTITY Transfer|nmod|Signaling Transfer|dep|Kinase Kinase|appos|END_ENTITY	Information Transfer in Gonadotropin-Releasing_Hormone -LRB- GnRH -RRB- Signaling : Extracellular Signal-Regulated Kinase -LRB- ERK -RRB- - Mediated Feedback Loops Control Hormone Sensing .
21719703	0	Gonadotropin-regulated_testicular_RNA_helicase	0,46	steroidogenic_acute_regulatory_protein	185,223	Gonadotropin-regulated testicular RNA helicase	steroidogenic acute regulatory protein	30959(Tax:10090)	20845(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Gonadotropin-regulated_testicular_RNA_helicase -LRB- GRTH/DDX25 -RRB- , a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells : central role of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- .
26338704	0	Gonadotropin-releasing_Hormone	136,166	Protein_Kinase_D1	15,32	Gonadotropin-releasing Hormone	Protein Kinase D1	2796	5587	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Protein_Kinase_D1 in Signal Transduction from the Protein_Kinase_C Pathway to the Tyrosine Kinase Pathway in Response to Gonadotropin-releasing_Hormone .
10482842	0	Gonadotropin-releasing_hormone	0,30	CD4	41,44	Gonadotropin-releasing hormone	CD4	25194(Tax:10116)	24932(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Gonadotropin-releasing_hormone increases CD4 T-lymphocyte numbers in an animal model of immunodeficiency .
19179479	0	Gonadotropin-releasing_hormone	0,30	ERK	65,68	Gonadotropin-releasing hormone	ERK	2796	5594	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Gonadotropin-releasing_hormone and protein kinase C signaling to ERK : spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases .
19179479	0	Gonadotropin-releasing_hormone	0,30	ERK	99,102	Gonadotropin-releasing hormone	ERK	2796	5594	Gene	Gene	signaling|compound|START_ENTITY signaling|dep|regulation regulation|nmod|END_ENTITY	Gonadotropin-releasing_hormone and protein kinase C signaling to ERK : spatiotemporal regulation of ERK by docking domains and dual-specificity phosphatases .
15492280	0	Gonadotropin-releasing_hormone	0,30	GnRH	32,36	Gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists promote proapoptotic signaling in peripheral reproductive_tumor cells by activating a Galphai-coupling state of the type I GnRH_receptor .
16712461	0	Gonadotropin-releasing_hormone	0,30	GnRH	32,36	Gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors in tumors : a new rationale for the therapeutical application of GnRH analogs in cancer patients ?
3123511	0	Gonadotropin-releasing_hormone	0,30	GnRH	32,36	Gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	suppression|amod|START_ENTITY suppression|appos|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- analog suppression renders polycystic_ovarian_disease patients more susceptible to ovulation induction with pulsatile GnRH .
9088896	0	Gonadotropin-releasing_hormone	0,30	GnRH	32,36	Gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- content in the median eminence after superior cervical ganglionectomy in ovariectomized and estrogen-treated rats .
11866452	0	Gonadotropin-releasing_hormone	0,30	annexin_5	42,51	Gonadotropin-releasing hormone	annexin 5	25194(Tax:10116)	25673(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Gonadotropin-releasing_hormone stimulates annexin_5 messenger ribonucleic acid expression in the anterior pituitary cells .
16627584	0	Gonadotropin-releasing_hormone	0,30	c-jun	45,50	Gonadotropin-releasing hormone	c-jun	2796	3725	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Gonadotropin-releasing_hormone activation of c-jun , but not early_growth_response_factor-1 , stimulates transcription of a luteinizing hormone beta-subunit gene .
22024993	0	Gonadotropin-releasing_hormone	0,30	gonadotropin-releasing_hormone_receptor	31,70	Gonadotropin-releasing hormone	gonadotropin-releasing hormone receptor	2796	2798	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Gonadotropin-releasing_hormone / gonadotropin-releasing_hormone_receptor signaling in the placenta .
19656390	0	Gonadotropin-releasing_hormone	0,30	integrin_beta3	132,146	Gonadotropin-releasing hormone	integrin beta3	2796	3690	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- - I and GnRH-II induce cell growth inhibition in human endometrial_cancer cells : involvement of integrin_beta3 and focal_adhesion_kinase .
12909491	0	Gonadotropin-releasing_hormone	0,30	interleukin-6	63,76	Gonadotropin-releasing hormone	interleukin-6	2796	3569	Gene	Gene	treatment|amod|START_ENTITY reduced|nsubj|treatment reduced|dobj|concentrations concentrations|amod|END_ENTITY	Gonadotropin-releasing_hormone agonist treatment reduced serum interleukin-6 concentrations in patients with ovarian_endometriomas .
23176180	0	Gonadotropin-releasing_hormone_receptor	0,39	RhoA	57,61	Gonadotropin-releasing hormone receptor	RhoA	2798	387	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Gonadotropin-releasing_hormone_receptor activates GTPase RhoA and inhibits cell invasion in the breast_cancer cell line MDA-MB-231 .
19366794	0	Gonadotropin-releasing_hormone_type_II	0,38	GADD45alpha	105,116	Gonadotropin-releasing hormone type II	GADD45alpha	2797	1647	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Gonadotropin-releasing_hormone_type_II induces apoptosis of human endometrial_cancer cells by activating GADD45alpha .
18703851	0	Gonadotropin_releasing_hormone	0,30	annexin_A5	47,57	Gonadotropin releasing hormone	annexin A5	2796	308	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Gonadotropin_releasing_hormone -LRB- GnRH -RRB- enhances annexin_A5 mRNA expression through mitogen activated protein kinase -LRB- MAPK -RRB- in LbetaT2 pituitary gonadotrope cells .
17971448	0	Gp120	0,5	CCR5	81,85	Gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	V3-dependent|amod|START_ENTITY impairment_of_R5_HIV-1_infectivity|nsubj|V3-dependent impairment_of_R5_HIV-1_infectivity|xcomp|due due|nmod|END_ENTITY	Gp120 V3-dependent impairment_of_R5_HIV-1_infectivity due to virion-incorporated CCR5 .
11517385	0	Gp120	0,5	CD4	55,58	Gp120	CD4	3700	920	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|nmod|END_ENTITY	Gp120 activates children 's brain endothelial cells via CD4 .
1933287	0	Gp120	56,61	CD4	79,82	Gp120	CD4	3700	920	Gene	Gene	START_ENTITY|acl:relcl|antigen antigen|compound|END_ENTITY	Brain-derived cells contain a specific binding site for Gp120 which is not the CD4 antigen .
8663408	0	Gp120	61,66	CD4	78,81	Gp120	CD4	3700	920	Gene	Gene	domain|nmod|START_ENTITY domain|acl:relcl|binds binds|dobj|END_ENTITY	A synthetic conformational epitope from the C4 domain of HIV Gp120 that binds CD4 .
26837416	0	Gp120	0,5	DC-SIGN	19,26	Gp120	DC-SIGN	155971(Tax:11676)	30835	Gene	Gene	binding|advmod|START_ENTITY binding|nmod|END_ENTITY	Gp120 binding with DC-SIGN induces reactivation of HIV-1 provirus via the NF-kB signaling pathway .
22457856	0	Gp130	121,126	IL-6	0,4	gp130	IL-6	16195(Tax:10090)	3569	Gene	Gene	subunits|amod|START_ENTITY mutations|nmod|subunits END_ENTITY|nmod|mutations	IL-6 and IL-11 as markers for tumor_aggressiveness and prognosis in gastric_adenocarcinoma patients without mutations in Gp130 subunits .
24378454	0	Gp130	55,60	IP3R	81,85	Gp130	IP3R	25205(Tax:10116)	25262(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Interleukin-6 prevents NMDA-induced neuronal_death via Gp130 signaling-dependent IP3R inhibition .
24378454	0	Gp130	55,60	Interleukin-6	0,13	Gp130	Interleukin-6	25205(Tax:10116)	24498(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY neuronal_death|nmod|inhibition prevents|dobj|neuronal_death prevents|nsubj|END_ENTITY	Interleukin-6 prevents NMDA-induced neuronal_death via Gp130 signaling-dependent IP3R inhibition .
12372336	0	Gp130	0,5	interleukin-6	51,64	Gp130	interleukin-6	3572	3569	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Gp130 activation by soluble interleukin-6_receptor / interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells .
9143707	0	Gp130	0,5	interleukin-6	14,27	Gp130	interleukin-6	3572	3569	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	Gp130 and the interleukin-6 family of cytokines .
9921985	0	Gp130	31,36	interleukin-6	55,68	Gp130	interleukin-6	3572	3569	Gene	Gene	chain|amod|START_ENTITY signaling|nmod|chain signaling|nmod|END_ENTITY	Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin_M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity .
8244399	0	Gp330	33,38	glycoprotein_330	15,31	Gp330	glycoprotein 330	14725(Tax:10090)	14725(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the glycoprotein_330 -LRB- Gp330 -RRB- gene to mouse chromosome 2 .
16828734	0	Gp330	27,32	megalin	12,19	Gp330	megalin	4036	4036	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of megalin -LRB- LRP-2 / Gp330 -RRB- during development .
20236244	0	GpBAR1	50,56	TGR5	58,62	GpBAR1	TGR5	227289(Tax:10090)	227289(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of the bile_acid receptor GpBAR1 -LRB- TGR5 -RRB- in the murine enteric nervous system .
25341886	0	GpIba	9,14	von_Willebrand_Factor	26,47	GpIba	von Willebrand Factor	2811	7450	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Platelet GpIba binding to von_Willebrand_Factor under fluid shear : contributions of the D D3-domain , A1-domain flanking peptide and O-linked glycans .
16793550	0	Gpb1	19,23	Ira1	115,119	Gpb1	Ira1	854553(Tax:4932)	852437(Tax:4932)	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2 .
20160012	0	Gpb1	71,75	Ira2	20,24	Gpb1	Ira2	854553(Tax:4932)	854073(Tax:4932)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans .
26164272	0	Gpd1	0,4	Tcp-1	31,36	Gpd1	Tcp-1	851539(Tax:4932)	851798(Tax:4932)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Activity Activity|nmod|END_ENTITY	Gpd1 Regulates the Activity of Tcp-1 and Heat Shock Response in Yeast Cells : Effect on Aggregation of Mutant Huntingtin .
16278447	0	Gpi19	0,5	PIG-P	59,64	Gpi19	PIG-P	852047(Tax:4932)	100154885(Tax:9823)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Gpi19 , the Saccharomyces_cerevisiae homologue of mammalian PIG-P , is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis .
17475886	0	Gpnmb	0,5	IFN-gamma	35,44	Gpnmb	IFN-gamma	93695(Tax:10090)	15978(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses .
22253604	0	Gpr27	60,65	insulin	69,76	Gpr27	insulin	2850	3630	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production .
17595229	0	Gpr54	54,59	Kiss1	0,5	Gpr54	Kiss1	114229(Tax:10090)	280287(Tax:10090)	Gene	Gene	hypogonadism|nmod|START_ENTITY END_ENTITY|parataxis|hypogonadism	Kiss1 - / - mice exhibit more variable hypogonadism than Gpr54 - / - mice .
21156837	0	Gpr54	0,5	Kiss1	67,72	Gpr54	Kiss1	114229(Tax:10090)	280287(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY show|nsubj|mice show|nmod|spermatogenesis spermatogenesis|nmod|mice mice|amod|END_ENTITY	Gpr54 - / - mice show more pronounced defects in spermatogenesis than Kiss1 - / - mice and improved spermatogenesis with age when exposed to dietary phytoestrogens .
21852382	0	Gpr54	55,60	Kiss1	40,45	Gpr54	Kiss1	84634	3814	Gene	Gene	delays|amod|START_ENTITY breast_tumor|nsubj|delays breast_tumor|nmod|receptor receptor|amod|END_ENTITY	Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast_tumor initiation , progression , and lung metastasis .
25547674	0	Gpr56	108,113	HSC	117,120	Gpr56	HSC	9289	2523	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation .
10846067	0	Gps2	6,10	p300	17,21	Gps2	p300	2874	2033	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	AMF-1 / Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins .
26674569	0	Gpx1	36,40	CAT	69,72	Gpx1	CAT	2876	847	Gene	Gene	Pro197Leu|nmod|START_ENTITY Pro197Leu|appos|C/T C/T|nmod|END_ENTITY	Genetic polymorphisms -LRB- Pro197Leu of Gpx1 , +35 A/C of SOD1 , -262 C/T of CAT -RRB- , the level of antioxidant proteins -LRB- GPx1 , SOD1 , CAT -RRB- and the risk of distal_symmetric_polyneuropathy in Polish patients with type_2_diabetes_mellitus .
12804009	0	Gpx1	170,174	glutathione_peroxidase-1	144,168	Gpx1	glutathione peroxidase-1	14775(Tax:10090)	14775(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	An imbalance in antioxidant defense affects cellular function : the pathophysiological consequences of a reduction in antioxidant defense in the glutathione_peroxidase-1 -LRB- Gpx1 -RRB- knockout mouse .
16339559	0	Gr-1	7,11	CD11b	0,5	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY immature|nsubj|+ +|parataxis|immature +|compound|END_ENTITY	CD11b + / Gr-1 + immature myeloid cells mediate suppression of T cells in mice bearing_tumors of IL-1beta-secreting cells .
19265258	0	Gr-1	55,59	CD11b	49,54	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Potential differentiation of tumor bearing mouse CD11b + Gr-1 + immature myeloid cells into both suppressor macrophages and immunostimulatory dendritic cells .
19789345	0	Gr-1	79,83	CD11b	84,89	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|amod|START_ENTITY cells|amod|+ cells|amod|END_ENTITY	Vascular_adhesion protein-1 enhances tumor growth by supporting recruitment of Gr-1 + CD11b + myeloid cells into tumors .
20631080	0	Gr-1	0,4	CD11b	5,10	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Gr-1 + CD11b + myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung .
21949025	0	Gr-1	33,37	CD11b	26,31	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	expands|nsubj|START_ENTITY expands|dobj|END_ENTITY	IL-33 expands suppressive CD11b + Gr-1 -LRB- int -RRB- and regulatory T cells , including ST2L + Foxp3 + cells , and mediates regulatory T cell-dependent promotion of cardiac allograft survival .
22030957	0	Gr-1	66,70	CD11b	72,77	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	UV light B-mediated inhibition of skin catalase activity promotes Gr-1 + CD11b + myeloid cell expansion .
22962327	0	Gr-1	123,127	CD11b	114,119	Gr-1	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Acceleration|dep|cells Acceleration|nmod|expression expression|nmod|END_ENTITY	Acceleration of collateral development by carcinoembryonic_antigen-related_cell_adhesion_molecule_1 expression on CD11b / Gr-1 myeloid cells -- brief report .
24645717	0	Gr-1	0,4	CD11b	5,10	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Gr-1 + CD11b + myeloid cells efficiently home to site of injury after intravenous administration and enhance diabetic wound healing by neoangiogenesis .
24758901	0	Gr-1	55,59	CD11b	47,52	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Hydrogen_sulfide attenuates the recruitment of CD11b Gr-1 myeloid cells and regulates Bax/Bcl -2 signaling in myocardial_ischemia injury .
24776637	0	Gr-1	0,4	CD11b	5,10	Gr-1	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	Gr-1 + CD11b + cells facilitate Lewis lung_cancer recurrence by enhancing neovasculature after local_irradiation .
25085111	0	Gr-1	74,78	CD11b	79,84	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|amod|START_ENTITY cells|amod|+ cells|amod|END_ENTITY	Liver metastases induce reversible hepatic B cell dysfunction mediated by Gr-1 + CD11b + myeloid cells .
25108427	0	Gr-1	17,21	CD11b	25,30	Gr-1	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	-LSB- Myeloid-derived Gr-1 CD11b suppressor cells are involved in immunoregulation of experimental_autoimmune_encephalomyelitis -RSB- .
25269085	0	Gr-1	0,4	CD11b	5,10	Gr-1	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Gr-1 + CD11b + Immature Myeloid Cells -LRB- IMC -RRB- Promote Resistance of Pro-Inflammatory T Cells to Suppression by Regulatory T Cells in Atherosclerotic Apo_E - Deficient Mice .
26582821	0	Gr-1	17,21	CD11b	23,28	Gr-1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|acquire acquire|nsubj|cells cells|amod|END_ENTITY	Immature myeloid Gr-1 + CD11b + cells from lipopolysaccharide-immunosuppressed mice acquire inhibitory activity in the bone marrow and migrate to lymph nodes to exert their suppressive function .
19409487	0	Gr-1	88,92	IL-23	8,13	Gr-1	IL-23	546644(Tax:10090)	83430(Tax:10090)	Gene	Gene	mobilization|nmod|START_ENTITY END_ENTITY|nmod|mobilization	Role of IL-23 in mobilization of immunoregulatory nitric_oxide - or superoxide-producing Gr-1 + cells from bone marrow .
16352631	0	Gr1	126,129	CD11b	130,135	Gr1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Granulocyte_colony-stimulating_factor promotes tumor angiogenesis via increasing circulating endothelial progenitor cells and Gr1 + CD11b + cells in cancer animal models .
17664940	0	Gr1	65,68	CD11b	59,64	Gr1	CD11b	14782(Tax:10090)	3684	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Tumor refractoriness to anti-VEGF treatment is mediated by CD11b + Gr1 + myeloid cells .
21184649	0	Gr1	17,20	CD11b	21,26	Gr1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Up-regulation of Gr1 + CD11b + population in spleen of dextran sulfate_sodium administered mice works to repair colitis .
21413942	0	Gr1	42,45	CD11b	48,53	Gr1	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Dextran sulphate_sodium increases splenic Gr1 -LRB- + -RRB- CD11b -LRB- + -RRB- cells which accelerate recovery from colitis following intravenous transplantation .
24072746	0	Gr1	51,54	CD11b	45,50	Gr1	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	growth|compound|START_ENTITY growth|amod|END_ENTITY	Parathyroid_hormone-related_protein drives a CD11b + Gr1 + cell-mediated positive feedback loop_to_support_prostate_cancer growth .
24343652	0	Gr1	65,68	CD11b	58,63	Gr1	CD11b	14782(Tax:10090)	16409(Tax:10090)	Gene	Gene	allergic_airway_inflammation|amod|START_ENTITY +|dobj|allergic_airway_inflammation +|nsubj|END_ENTITY	Salmonella_enterica_serovar_Typhimurium infection-induced CD11b + Gr1 + cells ameliorate allergic_airway_inflammation .
25008148	0	Gr1	15,18	CD11b	21,26	Gr1	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	F4/80|amod|START_ENTITY F4/80|amod|END_ENTITY	Recruitment of Gr1 -LRB- + -RRB- CD11b -LRB- + -RRB- F4/80 -LRB- + -RRB- Population in the Bone Marrow and Spleen by Irradiation-Induced Pulmonary Damage .
19616200	0	GrB	73,76	CD4	11,14	GrB	CD4	3002	920	Gene	Gene	granzyme_B|appos|START_ENTITY expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
17570460	0	GrB	6,9	CD8	131,134	GrB	CD8	3002	925	Gene	Gene	response|compound|START_ENTITY associated|nsubjpass|response associated|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Lower GrB + CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes .
17570460	0	GrB	6,9	CD8	21,24	GrB	CD8	3002	925	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Lower GrB + CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes .
19616200	0	GrB	73,76	CD8	15,18	GrB	CD8	3002	925	Gene	Gene	granzyme_B|appos|START_ENTITY expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
11432776	0	Graf	59,63	Graf2	81,86	Graf	Graf2	23092	79658	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein , Graf2 , which are GTPase activating proteins for Rho family .
11432776	0	Graf2	81,86	Graf	59,63	Graf2	Graf	79658	23092	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein , Graf2 , which are GTPase activating proteins for Rho family .
20938050	0	Grainyhead-like_2	0,17	telomerase_reverse_transcriptase	37,69	Grainyhead-like 2	telomerase reverse transcriptase	79977	7015	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Grainyhead-like_2 enhances the human telomerase_reverse_transcriptase gene expression by inhibiting DNA methylation at the 5 ' - CpG island in normal human keratinocytes .
24915580	0	Grainyhead-like_3	0,17	endothelin-1	32,44	Grainyhead-like 3	endothelin-1	57822	1906	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Grainyhead-like_3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton .
19692333	0	Gram-negative_binding_protein_3	36,67	GNBP3	69,74	Gram-negative binding protein 3	GNBP3	39020(Tax:7227)	39020(Tax:7227)	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The N-terminal domain of Drosophila Gram-negative_binding_protein_3 -LRB- GNBP3 -RRB- defines a novel family of fungal pattern recognition receptors .
26648480	0	Grancalcin	0,10	Toll-like_receptor_9	27,47	Grancalcin	Toll-like receptor 9	25801	54106	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Grancalcin -LRB- GCA -RRB- modulates Toll-like_receptor_9 -LRB- TLR9 -RRB- - mediated signaling through its direct interaction with TLR9 .
11107242	0	Granulocyte-Macrophage_Colony-Stimulating_Factor	11,59	GM-CSF	61,67	Granulocyte-Macrophage Colony-Stimulating Factor	GM-CSF	1437	1437	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	A Role for Granulocyte-Macrophage_Colony-Stimulating_Factor -LRB- GM-CSF -RRB- in the Treatment of Neutropenic Patients with Pneumonia .
12406901	0	Granulocyte-colony_stimulating_factor	0,37	CD62L	91,96	Granulocyte-colony stimulating factor	CD62L	1440	6402	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Granulocyte-colony_stimulating_factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expression .
18594210	0	Granulocyte-colony_stimulating_factor	0,37	ErbB2	50,55	Granulocyte-colony stimulating factor	ErbB2	1440	2064	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Granulocyte-colony_stimulating_factor upregulates ErbB2 expression on breast_cancer cell lines and converts primary resistance to trastuzumab .
25584775	0	Granulocyte-colony_stimulating_factor	0,37	TNFa	107,111	Granulocyte-colony stimulating factor	TNFa	12985(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- - induced mechanical_hyperalgesia in mice : Role for peripheral TNFa , IL-1b and IL-10 .
9594023	0	Granulocyte-colony_stimulating_factor	0,37	TNFalpha	47,55	Granulocyte-colony stimulating factor	TNFalpha	1440	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Granulocyte-colony_stimulating_factor inhibits TNFalpha production in a human hepatoma cell line .
23565130	0	Granulocyte-colony_stimulating_factor	0,37	stem_cell_factor	58,74	Granulocyte-colony stimulating factor	stem cell factor	25610(Tax:10116)	60427(Tax:10116)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Granulocyte-colony_stimulating_factor in combination with stem_cell_factor confers greater neuroprotection after hypoxic-ischemic_brain_damage in the neonatal rats than a solitary treatment .
16792532	0	Granulocyte-macrophage_colony-stimulating-factor	0,48	interferon-tau	59,73	Granulocyte-macrophage colony-stimulating-factor	interferon-tau	281095(Tax:9913)	317698(Tax:9913)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating-factor increases interferon-tau protein secretion in bovine trophectoderm cells .
8911145	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	CD14	64,68	Granulocyte-macrophage colony-stimulating factor	CD14	1437	929	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Granulocyte-macrophage_colony-stimulating_factor down-regulates CD14 expression on monocytes .
9332304	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	Cdk6	147,151	Granulocyte-macrophage colony-stimulating factor	Cdk6	1437	1021	Gene	Gene	abrogates|nsubj|START_ENTITY abrogates|nmod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor abrogates transforming_growth_factor-beta_1-mediated cell cycle arrest by up-regulating cyclin_D2 / Cdk6 .
2005129	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	Egr-1	87,92	Granulocyte-macrophage colony-stimulating factor	Egr-1	12981(Tax:10090)	13653(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor induces transcriptional activation of Egr-1 in murine peritoneal macrophages .
12421947	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	GM-CSF	209,215	Granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	12981(Tax:10090)	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|ectodomain ectodomain|nmod|receptor receptor|compound|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and inflammatory stimuli up-regulate secretion of the soluble GM-CSF receptor in human monocytes : evidence for ectodomain shedding of the cell surface GM-CSF receptor alpha subunit .
8631962	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	JAK2	60,64	Granulocyte-macrophage colony-stimulating factor	JAK2	1437	3717	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor stimulates JAK2 signaling pathway and rapidly activates p93fes , STAT1 p91 , and STAT3_p92 in polymorphonuclear leukocytes .
9440544	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	Jak2	108,112	Granulocyte-macrophage colony-stimulating factor	Jak2	1437	3717	Gene	Gene	activate|nsubj|START_ENTITY activate|nmod|kinase kinase|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils .
8695838	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	STAT5A	84,90	Granulocyte-macrophage colony-stimulating factor	STAT5A	1437	6776	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes .
3042442	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	cyclosporin_A	98,111	Granulocyte-macrophage colony-stimulating factor	cyclosporin A	12981(Tax:10090)	71991(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor regulation in murine T cells and its relation to cyclosporin_A .
12804136	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	gp96	105,109	Granulocyte-macrophage colony-stimulating factor	gp96	12981(Tax:10090)	22027(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor gene-transduced tumor cells combined with tumor-derived gp96 inhibit tumor growth in mice .
7528576	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	interleukin-1	135,148	Granulocyte-macrophage colony-stimulating factor	interleukin-1	1437	3552	Gene	Gene	expression|amod|START_ENTITY upregulated|nsubj|expression upregulated|advcl|downregulated downregulated|dep|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor expression by human fibroblasts is both upregulated and subsequently downregulated by interleukin-1 .
1450413	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	interleukin-3	49,62	Granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	START_ENTITY|appos|enhances enhances|nsubj|protein protein|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein -LRB- pIXY 321 -RRB- enhances high-dose Ara-C-induced programmed_cell_death or apoptosis in human myeloid_leukemia cells .
10840163	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	matrix_metalloproteinase-2	61,87	Granulocyte-macrophage colony-stimulating factor	matrix metalloproteinase-2	1437	4313	Gene	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor upregulates matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and membrane_type-1_MMP -LRB- MT1-MMP -RRB- in human head_and_neck_cancer cells .
11903618	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	nuclear_factor_kappa_B	80,102	Granulocyte-macrophage colony-stimulating factor	nuclear factor kappa B	1437	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor activates the transcription of nuclear_factor_kappa_B and induces the expression of nitric_oxide synthase in a skin dendritic cell line .
10792393	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	proteinase_3	150,162	Granulocyte-macrophage colony-stimulating factor	proteinase 3	1437	5657	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- but not granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- induces plasma membrane expression of proteinase_3 -LRB- PR3 -RRB- on neutrophils in vitro .
7867077	0	Granulocyte-macrophage_colony-stimulating_factor	0,48	tumor_necrosis_factor-alpha	101,128	Granulocyte-macrophage colony-stimulating factor	tumor necrosis factor-alpha	1437	7124	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|region region|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor and interleukin-4 differentially regulate the human tumor_necrosis_factor-alpha promoter region .
11145699	0	Granulocyte-macrophage_colony_stimulating_factor	0,48	CCR1	62,66	Granulocyte-macrophage colony stimulating factor	CCR1	1437	1230	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Granulocyte-macrophage_colony_stimulating_factor up-regulates CCR1 in human neutrophils .
10190115	0	Granulocyte-macrophage_colony_stimulating_factor	0,48	TNF_alpha	77,86	Granulocyte-macrophage colony stimulating factor	TNF alpha	1437	7124	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	Granulocyte-macrophage_colony_stimulating_factor modulates the production of TNF_alpha by differentiated U937 cells infected with Leishmania_major .
25730818	0	Granulocyte_Colony-Stimulating_Factor	70,107	CD34	120,124	Granulocyte Colony-Stimulating Factor	CD34	1440	947	Gene	Gene	Receptor|compound|START_ENTITY Potential|nmod|Receptor Associated|nmod|Potential Associated|nmod|END_ENTITY	miR-155 Is Associated with the Leukemogenic Potential of the Class IV Granulocyte_Colony-Stimulating_Factor Receptor in CD34 -LRB- + -RRB- Progenitor Cells .
27044752	0	Granulocyte_Colony_Stimulating_Factor	45,82	MTA1	37,41	Granulocyte Colony Stimulating Factor	MTA1	1440	9112	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of regulation of MTA1 by Granulocyte_Colony_Stimulating_Factor .
18066430	0	Granulocyte_Colony_Stimulating_Factor	56,93	hG-CSF	95,101	Granulocyte Colony Stimulating Factor	hG-CSF	1440	1440	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Production of transgenic goat -LRB- Capra_hircus -RRB- with human Granulocyte_Colony_Stimulating_Factor -LRB- hG-CSF -RRB- gene in Brazil .
11091218	0	Granulocyte_colony-stimulating_factor	0,37	CD114	74,79	Granulocyte colony-stimulating factor	CD114	1440	1441	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|receptor receptor|appos|END_ENTITY	Granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- downregulates its receptor -LRB- CD114 -RRB- on neutrophils and induces gelatinase B release in humans .
7543071	0	Granulocyte_colony-stimulating_factor	0,37	CD32	75,79	Granulocyte colony-stimulating factor	CD32	1440	2212	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- administration increases PMN CD32 -LRB- FcRII -RRB- expression and FcR-related functions .
10905051	0	Granulocyte_colony-stimulating_factor	0,37	CD34	108,112	Granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	modulation|compound|START_ENTITY modulation|acl|circulating circulating|dobj|cells cells|nummod|END_ENTITY	Granulocyte_colony-stimulating_factor and lineage-independent modulation of VLA-4 expression on circulating CD34 + cells .
12100131	0	Granulocyte_colony-stimulating_factor	0,37	CD34	89,93	Granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilized|nsubj|START_ENTITY mobilized|ccomp|graft graft|nsubj|blood blood|acl|containing containing|nmod|cells cells|compound|END_ENTITY	Granulocyte_colony-stimulating_factor mobilized whole blood containing over 0.3 x 106/kg CD34 + cells is a sufficient graft in autologous transplantation for relapsed non-Hodgkin 's _ lymphoma .
12542495	0	Granulocyte_colony-stimulating_factor	0,37	CD34	88,92	Granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	administration|compound|START_ENTITY upregulates|nsubj|administration upregulates|nmod|cells cells|nummod|END_ENTITY	Granulocyte_colony-stimulating_factor administration upregulates telomerase activity in CD34 + haematopoietic cells and may prevent telomere attrition after chemotherapy .
15377480	0	Granulocyte_colony-stimulating_factor	0,37	CD34	55,59	Granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Granulocyte_colony-stimulating_factor after autologous CD34 + immunoselected peripheral blood stem cell transplantation .
22119930	0	Granulocyte_colony-stimulating_factor	0,37	CD34	48,52	Granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilizes|nsubj|START_ENTITY mobilizes|dobj|cells cells|amod|END_ENTITY	Granulocyte_colony-stimulating_factor mobilizes CD34 -LRB- + -RRB- cells and improves survival of patients with acute-on-chronic_liver_failure .
24056818	0	Granulocyte_colony-stimulating_factor	0,37	CD34	109,113	Granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	produces|nsubj|START_ENTITY produces|nmod|cells cells|nummod|END_ENTITY	Granulocyte_colony-stimulating_factor produces long-term changes in gene and microRNA expression profiles in CD34 + cells from healthy donors .
8704221	0	Granulocyte_colony-stimulating_factor	0,37	CD34	53,57	Granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	recruitment|amod|START_ENTITY recruitment|nmod|progenitors progenitors|nummod|END_ENTITY	Granulocyte_colony-stimulating_factor recruitment of CD34 + progenitors to peripheral blood : impaired mobilization in chronic_granulomatous_disease and adenosine_deaminase -- deficient severe_combined_immunodeficiency_disease patients .
7511947	0	Granulocyte_colony-stimulating_factor	0,37	CD62	65,69	Granulocyte colony-stimulating factor	CD62	1440	6403	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Granulocyte_colony-stimulating_factor enhances the expression of CD62 on platelets in vivo .
12393561	0	Granulocyte_colony-stimulating_factor	0,37	cytochrome_c	59,71	Granulocyte colony-stimulating factor	cytochrome c	1440	54205	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Granulocyte_colony-stimulating_factor inhibits spontaneous cytochrome_c release and mitochondria-dependent apoptosis of myelodysplastic_syndrome hematopoietic progenitors .
7680917	0	Granulocyte_colony-stimulating_factor	0,37	hFc_gamma_RI	46,58	Granulocyte colony-stimulating factor	hFc gamma RI	1440	2209	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Granulocyte_colony-stimulating_factor induces hFc_gamma_RI -LRB- CD64 antigen -RRB- - positive neutrophils via an effect on myeloid precursor cells .
7692935	0	Granulocyte_colony-stimulating_factor	0,37	leucocyte_adhesion_molecule-1	89,118	Granulocyte colony-stimulating factor	leucocyte adhesion molecule-1	1440	6402	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Granulocyte_colony-stimulating_factor down-regulates the surface expression of the human leucocyte_adhesion_molecule-1 on human neutrophils in vitro and in vivo .
15627641	0	Granulocyte_colony-stimulating_factor	0,37	tumor_necrosis_factor	48,69	Granulocyte colony-stimulating factor	tumor necrosis factor	1440	7124	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|compound|END_ENTITY	Granulocyte_colony-stimulating_factor decreases tumor_necrosis_factor production in whole blood : role of interleukin-10 and prostaglandin_E -LRB- 2 -RRB- .
7545022	0	Granulocyte_colony-stimulating_factor	0,37	tumor_necrosis_factor-alpha	117,144	Granulocyte colony-stimulating factor	tumor necrosis factor-alpha	1440	7124	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|inhibition inhibition|nmod|production production|amod|END_ENTITY	Granulocyte_colony-stimulating_factor downregulates allogeneic immune responses by posttranscriptional inhibition of tumor_necrosis_factor-alpha production .
16360206	0	Granulocyte_macrophage-colony_stimulating_factor	0,48	SHP-2	73,78	Granulocyte macrophage-colony stimulating factor	SHP-2	1437	5781	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Granulocyte_macrophage-colony_stimulating_factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils : a new mechanism of action for SHP-2 .
8722638	0	Granulocyte_macrophage_colony_stimulating_factor	0,48	CD23	72,76	Granulocyte macrophage colony stimulating factor	CD23	1437	2208	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Granulocyte_macrophage_colony_stimulating_factor induces Fc_epsilon_RII / CD23 expression on normal human polymorphonuclear neutrophils .
8722638	0	Granulocyte_macrophage_colony_stimulating_factor	0,48	Fc_epsilon_RII	57,71	Granulocyte macrophage colony stimulating factor	Fc epsilon RII	1437	2208	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Granulocyte_macrophage_colony_stimulating_factor induces Fc_epsilon_RII / CD23 expression on normal human polymorphonuclear neutrophils .
20660289	0	Granulysin	0,10	TLR4	54,58	Granulysin	TLR4	10578	7099	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Granulysin activates antigen-presenting_cells through TLR4 and acts as an immune alarmin .
19454696	0	Granulysin	0,10	cathepsin_B	19,30	Granulysin	cathepsin B	10578	1508	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Granulysin induces cathepsin_B release from lysosomes of target_tumor cells to attack mitochondria through processing of bid leading to Necroptosis .
8754861	1	Granzyme_A	48,58	IL6	67,70	Granzyme A	IL6	3001	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	I. Granzyme_A induces IL6 and IL8 production in fibroblast and epithelial cell lines .
26497600	0	Granzyme_A	41,51	SERPINB12	0,9	Granzyme A	SERPINB12	3001	89777	Gene	Gene	Inhibitor|nmod|START_ENTITY Inhibitor|nsubj|END_ENTITY	SERPINB12 Is a Slow-Binding Inhibitor of Granzyme_A and Hepsin .
8058766	0	Granzyme_A	0,10	thrombin_receptor	78,95	Granzyme A	thrombin receptor	14938(Tax:10090)	14062(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Granzyme_A released upon stimulation of cytotoxic T lymphocytes activates the thrombin_receptor on neuronal cells and astrocytes .
26884645	0	Granzyme_B	35,45	CD5	60,63	Granzyme B	CD5	3002	921	Gene	Gene	START_ENTITY|nmod|B B|compound|END_ENTITY	Increased IL-21 Expression Induces Granzyme_B in Peripheral CD5 -LRB- + -RRB- B Cells as a Potential Counter-Regulatory Effect in Primary Sj gren 's Syndrome .
17825804	0	Granzyme_B	0,10	CD8	55,58	Granzyme B	CD8	3002	925	Gene	Gene	production|compound|START_ENTITY distinguishes|nsubj|production distinguishes|dobj|cells cells|nummod|END_ENTITY	Granzyme_B production distinguishes recently activated CD8 -LRB- + -RRB- memory cells from resting memory cells .
25245659	0	Granzyme_B	0,10	CD8	95,98	Granzyme B	CD8	3002	925	Gene	Gene	cells|amod|START_ENTITY regulated|nsubjpass|cells regulated|advcl|cells cells|compound|END_ENTITY	Granzyme_B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells .
12917638	0	Grap-2	0,6	RET	16,19	Grap-2	RET	17444(Tax:10090)	19713(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Grap-2 , a novel RET binding protein , is involved in RET mitogenic signaling .
11313918	0	Grap2	35,40	hematopoietic_progenitor_kinase_1	56,89	Grap2	hematopoietic progenitor kinase 1	9402	11184	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic_progenitor_kinase_1 -LRB- HPK1 -RRB- to activate JNK signaling pathway in T lymphocytes .
11230180	0	Grb-2	113,118	IRS-1	81,86	Grb-2	IRS-1	2885	3667	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|compound|END_ENTITY	PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1 / Grb-2 / Sos complex formation in a breast_cancer model .
15174222	0	Grb-2-related_adaptor_protein	13,42	GRAP	49,53	Grb-2-related adaptor protein	GRAP	71520(Tax:10090)	71520(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of Grb-2-related_adaptor_protein gene -LRB- GRAP -RRB- and peptide molecule in salivary glands of MRL/lpr mice and patients with Sj __ gren 's _ syndrome .
11809791	0	Grb10	29,34	Akt	56,59	Grb10	Akt	14783(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Role for the adaptor protein Grb10 in the activation of Akt .
12493740	0	Grb10	0,5	IRS-1	152,157	Grb10	IRS-1	2887	3667	Gene	Gene	substrate|compound|START_ENTITY substrate|dep|3-kinase/Akt 3-kinase/Akt|acl|signaling signaling|advcl|disrupting disrupting|dobj|association association|nmod|IRS-2 IRS-2|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
9553107	0	Grb10	19,24	Raf1	50,54	Grb10	Raf1	2887	5894	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases .
9506989	0	Grb10	142,147	epidermal_growth_factor_receptor	101,133	Grb10	epidermal growth factor receptor	2887	1956	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Grb10 interacts differentially with the insulin_receptor , insulin-like growth factor I receptor , and epidermal_growth_factor_receptor via the Grb10 Src homology 2 -LRB- SH2 -RRB- domain and a second novel domain located between the pleckstrin homology and SH2 domains .
12493740	0	Grb10	0,5	insulin_receptor	173,189	Grb10	insulin receptor	2887	3643	Gene	Gene	substrate|compound|START_ENTITY substrate|dep|3-kinase/Akt 3-kinase/Akt|acl|signaling signaling|advcl|disrupting disrupting|dobj|association association|nmod|IRS-2 IRS-2|nmod|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
12493740	0	Grb10	0,5	insulin_receptor	34,50	Grb10	insulin receptor	2887	3643	Gene	Gene	substrate|compound|START_ENTITY substrate|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
16434550	0	Grb10	0,5	insulin_receptor	53,69	Grb10	insulin receptor	2887	3643	Gene	Gene	mediates|nummod|START_ENTITY insulin-stimulated|nmod:npmod|mediates degradation|amod|insulin-stimulated degradation|nmod|END_ENTITY	Grb10 mediates insulin-stimulated degradation of the insulin_receptor : a mechanism of negative regulation .
9506989	0	Grb10	0,5	insulin_receptor	40,56	Grb10	insulin receptor	2887	3643	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Grb10 interacts differentially with the insulin_receptor , insulin-like growth factor I receptor , and epidermal_growth_factor_receptor via the Grb10 Src homology 2 -LRB- SH2 -RRB- domain and a second novel domain located between the pleckstrin homology and SH2 domains .
20973951	0	Grb14	28,33	Tie2	37,41	Grb14	Tie2	2888	7010	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Grb14 by Tie2 .
18346204	0	Grb2	23,27	Axl	10,13	Grb2	Axl	14784(Tax:10090)	26362(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	In brain , Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase ; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation .
24475931	0	Grb2	106,110	CD28	54,58	Grb2	CD28	2885	940	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2 , Gads and p85 PI3K .
15182856	0	Grb2	15,19	Catalase	0,8	Grb2	Catalase	2885	847	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Catalase binds Grb2 in tumor cells when stimulated with serum or ligands for integrin receptors .
11399323	0	Grb2	37,41	Cbl	28,31	Grb2	Cbl	2885	867	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Differential interaction of Cbl with Grb2 and CrkL in CD2-mediated NK cell activation .
17904548	0	Grb2	0,4	Cbl	97,100	Grb2	Cbl	2885	867	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|receptor/c-Kit receptor/c-Kit|acl|signaling signaling|nmod|recruitment recruitment|nmod|END_ENTITY	Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl .
17202467	0	Grb2	74,78	DISC1	0,5	Grb2	DISC1	81504(Tax:10116)	307940(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2 .
11371563	1	Grb2	154,158	DOC-2	85,90	Grb2	DOC-2	2885	1601	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	DOC-2 / DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2 .
20460816	0	Grb2	41,45	FGF2	0,4	Grb2	FGF2	2885	2247	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	FGF2 induces ERK phosphorylation through Grb2 and PKC during quiescent myogenic cell activation .
19735729	0	Grb2	18,22	FGFR2	37,42	Grb2	FGFR2	2885	2263	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function .
18789888	0	Grb2	20,24	Fas_ligand	48,58	Grb2	Fas ligand	2885	356	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The adaptor protein Grb2 regulates cell surface Fas_ligand in Schwann cells .
12852788	0	Grb2	28,32	G6f	65,68	Grb2	G6f	2885	259215	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f , a novel member of the immunoglobulin superfamily encoded in the MHC .
10811803	0	Grb2	15,19	Gads	21,25	Grb2	Gads	2885	9402	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of Grb2 , Gads , and phospholipase_C-gamma_1 with phosphorylated LAT tyrosine residues .
8824290	0	Grb2	101,105	Gastrin	0,7	Grb2	Gastrin	2885	2520	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
10224278	0	Grb2	15,19	Grf40	0,5	Grb2	Grf40	2885	9402	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	Grf40 , A novel Grb2 family member , is involved in T cell signaling through interaction with SLP-76 and LAT .
9670936	0	Grb2	40,44	Growth_factor_receptor-bound_protein_2	0,38	Grb2	Growth factor receptor-bound protein 2	14784(Tax:10090)	14784(Tax:10090)	Gene	Gene	association|appos|START_ENTITY association|amod|END_ENTITY	Growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- association with hemopoietic_specific_protein_1 : linkage between Lck and Grb2 .
21179510	0	Grb2	61,65	Histidine_domain-protein_tyrosine_phosphatase	0,45	Grb2	Histidine domain-protein tyrosine phosphatase	2885	25930	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Histidine_domain-protein_tyrosine_phosphatase interacts with Grb2 and GrpL .
9733714	0	Grb2	0,4	MEK-kinase_1	22,34	Grb2	MEK-kinase 1	2885	4214	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Grb2 interaction with MEK-kinase_1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor .
7500025	0	Grb2	36,40	Oncostatin_M	0,12	Grb2	Oncostatin M	2885	5008	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	Oncostatin_M induces association of Grb2 with Janus kinase JAK2 in multiple_myeloma cells .
9135065	0	Grb2	167,171	PEST	52,56	Grb2	PEST	14784(Tax:10090)	19248(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Coupling of the murine protein tyrosine phosphatase PEST to the epidermal_growth_factor _ -LRB- EGF -RRB- _ receptor through a Src homology 3 -LRB- SH3 -RRB- domain-mediated association with Grb2 .
7518443	0	Grb2	109,113	R-PTP-alpha	30,41	Grb2	R-PTP-alpha	2885	5786	Gene	Gene	tyrosine-phosphorylated|nmod|START_ENTITY tyrosine-phosphorylated|nsubjpass|END_ENTITY	Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2 .
9233777	0	Grb2	15,19	Raf-1	42,47	Grb2	Raf-1	2885	5894	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast_cancer cells .
24399467	0	Grb2	0,4	SGEF	20,24	Grb2	SGEF	2885	26084	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Grb2 interacts with SGEF and antagonizes the ability of SGEF to enhance EGF-induced ERK1/2 activation .
7947763	0	Grb2	89,93	SH3	75,78	Grb2	SH3	14784(Tax:10090)	100125849(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy .
7535773	0	Grb2	89,93	SHC	51,54	Grb2	SHC	2885	6464	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Growth_hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2 .
10749687	0	Grb2	227,231	Shc	215,218	Grb2	Shc	2885	6464	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|cytoskeleton cytoskeleton|nmod|END_ENTITY	Involvement of proline-rich_tyrosine_kinase_2 in platelet activation : tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C , translocation to the cytoskeleton and association with Shc through Grb2 .
7523859	0	Grb2	90,94	Shc	115,118	Grb2	Shc	2885	6464	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc .
7523859	0	Grb2	90,94	Shc	79,82	Grb2	Shc	2885	6464	Gene	Gene	site|amod|START_ENTITY stimulate|nmod|site stimulate|nmod|END_ENTITY	Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc .
7529871	0	Grb2	54,58	Shc	15,18	Grb2	Shc	2885	6464	Gene	Gene	association|nmod|START_ENTITY regulates|dobj|association regulates|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of Shc with Grb2 regulates association of Grb2 with mSOS .
9199344	0	Grb2	17,21	Shc	0,3	Grb2	Shc	2885	6464	Gene	Gene	binding|nmod:npmod|START_ENTITY sites|amod|binding contains|dobj|sites contains|nsubj|END_ENTITY	Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes .
18778683	0	Grb2	67,71	Sos1	122,126	Grb2	Sos1	2885	6654	Gene	Gene	domains|nmod|START_ENTITY differential|nmod|domains basis|nmod|differential adaptor|nsubj|basis adaptor|nmod|END_ENTITY	Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine_nucleotide exchange factor Sos1 .
19323566	0	Grb2	15,19	Sos1	63,67	Grb2	Sos1	2885	6654	Gene	Gene	adaptor|amod|START_ENTITY domains|nmod|adaptor bind|nsubj|domains bind|xcomp|PXpsiPXR PXpsiPXR|nmod|factor factor|amod|END_ENTITY	SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner .
24775912	0	Grb2	15,19	Sos1	77,81	Grb2	Sos1	14784(Tax:10090)	20662(Tax:10090)	Gene	Gene	SUMOylation|nmod|START_ENTITY enhances|nsubj|SUMOylation enhances|advcl|increasing increasing|nmod|END_ENTITY	SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1 .
7629138	0	Grb2	54,58	Sos1	35,39	Grb2	Sos1	2885	6654	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Differential interactions of human Sos1 and Sos2 with Grb2 .
8649846	0	Grb2	29,33	Sos1	0,4	Grb2	Sos1	2885	6654	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF_receptor after EGF stimulation .
8816480	0	Grb2	122,126	Sos1	86,90	Grb2	Sos1	2885	6654	Gene	Gene	regulate|nmod|START_ENTITY END_ENTITY|acl:relcl|regulate	Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2 .
17689925	0	Grb2	15,19	Sprouty2	0,8	Grb2	Sprouty2	2885	10253	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Sprouty2 binds Grb2 at two different proline-rich regions , and the mechanism of ERK inhibition is independent of this interaction .
14498832	0	Grb2	0,4	Stat3	15,20	Grb2	Stat3	2885	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling .
12115002	0	Grb2	53,57	Syp	0,3	Grb2	Syp	2885	6855	Gene	Gene	Mediate|nmod|START_ENTITY Mediate|nsubj|END_ENTITY	Syp Y279 , Y304 Can Mediate the Binding of Bcr-Abl to Grb2 and Other Proteins .
26511382	0	Grb2	15,19	TGF-b2	0,6	Grb2	TGF-b2	2885	7042	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TGF-b2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP -1 - signaling and augments invasiveness of Theileria-transformed macrophages .
7809090	0	Grb2	18,22	Vav	11,14	Grb2	Vav	2885	7409	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Vav to Grb2 through dimerization of Src homology 3 domains .
7629168	0	Grb2	140,144	ZAP-70	76,82	Grb2	ZAP-70	2885	7535	Gene	Gene	phospholipase_C-gamma_1|nmod|START_ENTITY phospholipase_C-gamma_1|amod|END_ENTITY	Ligation of the T-cell_antigen_receptor -LRB- TCR -RRB- induces association of hSos1 , ZAP-70 , phospholipase_C-gamma_1 , and other phosphoproteins with Grb2 and the zeta-chain of the TCR .
24116161	0	Grb2	0,4	foxd3	21,26	Grb2	foxd3	14784(Tax:10090)	15221(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin .
16760435	0	Grb2	0,4	hSos1	66,71	Grb2	hSos1	2885	6654	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|activity activity|nmod|END_ENTITY	Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1 .
7629168	0	Grb2	140,144	hSos1	69,74	Grb2	hSos1	2885	6654	Gene	Gene	phospholipase_C-gamma_1|nmod|START_ENTITY phospholipase_C-gamma_1|amod|END_ENTITY	Ligation of the T-cell_antigen_receptor -LRB- TCR -RRB- induces association of hSos1 , ZAP-70 , phospholipase_C-gamma_1 , and other phosphoproteins with Grb2 and the zeta-chain of the TCR .
8479541	0	Grb2	51,55	hSos1	36,41	Grb2	hSos1	2885	6654	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling .
8649768	0	Grb2	133,137	hSos1	94,99	Grb2	hSos1	2885	6654	Gene	Gene	affinity|amod|START_ENTITY expressed|nmod|affinity expressed|dobj|isoforms isoforms|amod|END_ENTITY	A 15 amino_acid stretch close to the Grb2-binding domain defines two differentially expressed hSos1 isoforms with markedly different Grb2 binding affinity and biological activity .
9670936	0	Grb2	40,44	hemopoietic_specific_protein_1	63,93	Grb2	hemopoietic specific protein 1	14784(Tax:10090)	15163(Tax:10090)	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- association with hemopoietic_specific_protein_1 : linkage between Lck and Grb2 .
8824290	0	Grb2	101,105	insulin_receptor_substrate_1	47,75	Grb2	insulin receptor substrate 1	2885	3667	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
7670467	0	Grb2	4,8	mSos1	27,32	Grb2	mSos1	2885	20662(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The Grb2 binding domain of mSos1 is not required for downstream signal transduction .
16038803	0	Grb2	0,4	phospholipase_C-gamma1	58,80	Grb2	phospholipase C-gamma1	2885	5335	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Grb2 negatively regulates epidermal_growth_factor-induced phospholipase_C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase_C-gamma1 .
15026337	0	Grb2-associated_binder_1	12,36	SHP-2	37,42	Grb2-associated binder 1	SHP-2	14388(Tax:10090)	19247(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|interaction interaction|compound|END_ENTITY	Role of the Grb2-associated_binder_1 / SHP-2 interaction in cell growth and transformation .
12941962	0	Grb2-associated_binder_1	19,43	Src	0,3	Grb2-associated binder 1	Src	14388(Tax:10090)	20779(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Src phosphorylates Grb2-associated_binder_1 upon hepatocyte_growth_factor stimulation .
15356145	0	Grb2-associated_binder_2	19,43	SHP-2	117,122	Grb2-associated binder 2	SHP-2	9846	5781	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of Grb2-associated_binder_2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation .
16456001	0	Grb2-associated_binder_2	20,44	Syk	54,57	Grb2-associated binder 2	Syk	9846	6850	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Scaffolding adapter Grb2-associated_binder_2 requires Syk to transmit signals from FcepsilonRI .
18853468	0	Grb7	27,31	Grb7	84,88	Grb7	Grb7	2886	2886	Gene	Gene	START_ENTITY|nmod|manner manner|amod|END_ENTITY	The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner .
18853468	0	Grb7	84,88	Grb7	27,31	Grb7	Grb7	2886	2886	Gene	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner .
20665473	0	Grb7	0,4	Hax-1	14,19	Grb7	Hax-1	2886	10456	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation .
20665473	0	Grb7	95,99	Hax-1	14,19	Grb7	Hax-1	2886	10456	Gene	Gene	regulation|amod|START_ENTITY model|nmod|regulation offers|dobj|model association|acl:relcl|offers binds|dobj|association binds|nmod|END_ENTITY	Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation .
10446223	0	Grb7	42,46	focal_adhesion_kinase	15,36	Grb7	focal adhesion kinase	2886	5747	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of focal_adhesion_kinase with Grb7 and its role in cell migration .
10893408	0	Grb7	8,12	focal_adhesion_kinase	68,89	Grb7	focal adhesion kinase	14786(Tax:10090)	14083(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|acl|targeting targeting|nmod|END_ENTITY	Role of Grb7 targeting to focal contacts and its phosphorylation by focal_adhesion_kinase in regulation of cell migration .
26474901	0	Greatwall	16,25	PP1	0,3	Greatwall	PP1	84930	5464	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	PP1 inactivates Greatwall to release PP2A-B55 from mitotic confinement .
21281623	0	Grem1	15,20	Six1	0,4	Grem1	Six1	23892(Tax:10090)	20471(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis .
23748100	0	Gremlin	0,7	TGFb	45,49	Gremlin	TGFb	26585	7040	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|END_ENTITY	Gremlin utilizes canonical and non-canonical TGFb signaling to induce lysyl_oxidase -LRB- LOX -RRB- genes in human trabecular meshwork cells .
20660291	0	Gremlin	0,7	VEGFR2	63,69	Gremlin	VEGFR2	26585	3791	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2 .
22644325	0	Gremlin1	48,56	BMP2	0,4	Gremlin1	BMP2	23892(Tax:10090)	12156(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	BMP2 differentially regulates the expression of Gremlin1 and Gremlin2 , the negative regulators of BMP function , during osteoblast differentiation .
10224278	0	Grf40	0,5	Grb2	15,19	Grf40	Grb2	9402	2885	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	Grf40 , A novel Grb2 family member , is involved in T cell signaling through interaction with SLP-76 and LAT .
24099773	0	Grg4	20,24	BMP	54,57	Grg4	BMP	7091	649	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling .
19332113	0	Grg4	44,48	Cux1	24,28	Grg4	Cux1	7091	1523	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The homeodomain protein Cux1 interacts with Grg4 to repress p27_kip1 expression during kidney development .
24099773	0	Grg4	20,24	Smad7	36,41	Grg4	Smad7	7091	4092	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling .
15183720	0	Grg5	18,22	Runx2-Cbfa1	63,74	Grg5	Runx2-Cbfa1	14797(Tax:10090)	12393(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice .
16949565	0	Grhl3	52,57	Get-1	46,51	Grhl3	Get-1	57822	230824(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	The Grainyhead-like epithelial transactivator Get-1 / Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4 .
14570909	0	Grim	20,24	X_chromosome-linked_inhibitor_of_apoptosis	84,126	Grim	X chromosome-linked inhibitor of apoptosis	40014(Tax:7227)	331	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Unlike Diablo/smac , Grim promotes global ubiquitination and specific degradation of X_chromosome-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- and neither cause apoptosis .
23811393	0	Grin2b	120,126	brain-derived_neurotrophic_factor	58,91	Grin2b	brain-derived neurotrophic factor	24410(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Status_epilepticus triggers early and late alterations in brain-derived_neurotrophic_factor and NMDA_glutamate receptor Grin2b DNA methylation levels in the hippocampus .
18039972	0	Grip	49,53	Perdido	26,33	Grip	Perdido	50391(Tax:7227)	35104(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo .
22940879	0	Grk2	0,4	CXCR7	34,39	Grk2	CXCR7	156	57007	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Grk2 is an essential regulator of CXCR7 signalling in astrocytes .
17430614	0	Grm6	83,87	nob4	66,70	Grm6	nob4	108072(Tax:10090)	108072(Tax:10090)	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	Generation , identification and functional characterization of the nob4 mutation of Grm6 in the mouse .
17363596	0	Gro-beta	39,47	Mullerian-inhibiting_substance	0,30	Gro-beta	Mullerian-inhibiting substance	2920	268	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Mullerian-inhibiting_substance induces Gro-beta expression in breast_cancer cells through a nuclear_factor-kappaB-dependent and Smad1-dependent mechanism .
12680712	0	GroEL	23,28	ATPase	4,10	GroEL	ATPase	3329	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The ATPase activity of GroEL is supported at high temperatures by divalent cations that stabilize its structure .
12110894	0	GroEL	23,28	GroES	29,34	GroEL	GroES	3329	3336	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	NMR analysis of a 900K GroEL GroES complex .
12270644	0	GroEL	25,30	GroES	40,45	GroEL	GroES	3329	3336	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	The bacterial chaperonin GroEL requires GroES to reduce aggregation and cell death in a COS-7 cell model of Huntington 's _ disease .
10354275	0	GroEL	50,55	IgA_nephropathy	74,89	GroEL	IgA nephropathy	3329	60498	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Small bowel T cells , HLA class II antigen DR , and GroEL stress protein in IgA_nephropathy .
12110894	0	GroES	29,34	GroEL	23,28	GroES	GroEL	3336	3329	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	NMR analysis of a 900K GroEL GroES complex .
12270644	0	GroES	40,45	GroEL	25,30	GroES	GroEL	3336	3329	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	The bacterial chaperonin GroEL requires GroES to reduce aggregation and cell death in a COS-7 cell model of Huntington 's _ disease .
9315866	0	GroES	0,5	GroES	65,70	GroES	GroES	3336	3336	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	GroES promotes the T to R transition of the GroEL ring distal to GroES in the GroEL-GroES complex .
9315866	0	GroES	65,70	GroES	0,5	GroES	GroES	3336	3336	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	GroES promotes the T to R transition of the GroEL ring distal to GroES in the GroEL-GroES complex .
11745457	0	Gro_1	38,43	IL-1alpha	149,158	Gro 1	IL-1alpha	14825(Tax:10090)	16175(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of proangiogenic chemokine Gro_1 in low and high metastatic variants of Pam murine squamous_cell_carcinoma is differentially regulated by IL-1alpha , EGF and TGF-beta1 through NF-kappaB dependent and independent mechanisms .
24416635	0	Gross_Cystic_Disease_Fluid_Protein-15	0,37	PIP	77,80	Gross Cystic Disease Fluid Protein-15	PIP	5304	5304	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Gross_Cystic_Disease_Fluid_Protein-15 -LRB- GCDFP-15 -RRB- / Prolactin-Inducible_Protein -LRB- PIP -RRB- as Functional Salivary Biomarker for Primary Sj gren 's Syndrome .
25070172	0	Gross_cystic_disease_fluid_protein_15	0,37	GCDFP-15	39,47	Gross cystic disease fluid protein 15	GCDFP-15	5304	5304	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Gross_cystic_disease_fluid_protein_15 -LRB- GCDFP-15 -RRB- expression in breast_cancer subtypes .
9874198	0	Groucho	73,80	Transducin-like_Enhancer_of_split_2	0,35	Groucho	Transducin-like Enhancer of split 2	43162(Tax:7227)	7089	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Transducin-like_Enhancer_of_split_2 , a mammalian homologue of Drosophila Groucho , acts as a transcriptional repressor , interacts with Hairy/Enhancer _ of_split proteins , and is expressed during neuronal development .
20844270	0	Group_X_secretory_phospholipase_A2	0,34	ABCA1	56,61	Group X secretory phospholipase A2	ABCA1	26565(Tax:10090)	11303(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Group_X_secretory_phospholipase_A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages .
21622863	0	Group_X_secretory_phospholipase_A2	0,34	TLR4	44,48	Group X secretory phospholipase A2	TLR4	26565(Tax:10090)	21898(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Group_X_secretory_phospholipase_A2 enhances TLR4 signaling in macrophages .
20421306	0	Group_X_secretory_phospholipase_A2	0,34	steroidogenic_acute_regulatory_protein	63,101	Group X secretory phospholipase A2	steroidogenic acute regulatory protein	26565(Tax:10090)	20845(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Group_X_secretory_phospholipase_A2 regulates the expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in mouse adrenal glands .
23571515	0	Growth-arrest-specific_6	0,24	GAS6	26,30	Growth-arrest-specific 6	GAS6	2621	2621	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Growth-arrest-specific_6 -LRB- GAS6 -RRB- protein in ARDS patients : determination of plasma levels and influence of PEEP setting .
26552404	0	Growth_Arrest-Specific_Protein_6	22,54	Gas6	56,60	Growth Arrest-Specific Protein 6	Gas6	14456(Tax:10090)	14456(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Protective Effects of Growth_Arrest-Specific_Protein_6 -LRB- Gas6 -RRB- on Sepsis-Induced Acute_Kidney_Injury .
26740594	0	Growth_Arrest_Specific-1	0,24	C/EBP	37,42	Growth Arrest Specific-1	C/EBP	14451(Tax:10090)	12606(Tax:10090)	Gene	Gene	Gene|nsubj|START_ENTITY Gene|compound|END_ENTITY	Growth_Arrest_Specific-1 -LRB- GAS1 -RRB- Is a C/EBP Target Gene That Functions in Ovulation and Corpus Luteum Formation in Mice .
26393302	0	Growth_Differentiation_Factor-8	0,31	Smad3	80,85	Growth Differentiation Factor-8	Smad3	2660	4088	Gene	Gene	Expression|compound|START_ENTITY Pathways|nsubj|Expression Pathways|nmod|END_ENTITY	Growth_Differentiation_Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells .
26393302	0	Growth_Differentiation_Factor-8	0,31	StAR	42,46	Growth Differentiation Factor-8	StAR	2660	6770	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Growth_Differentiation_Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells .
25590623	0	Growth_Differentiation_Factor_15	0,32	GDF-15	34,40	Growth Differentiation Factor 15	GDF-15	9518	9518	Gene	Gene	Levels|amod|START_ENTITY Levels|appos|END_ENTITY	Growth_Differentiation_Factor_15 -LRB- GDF-15 -RRB- Plasma Levels Increase during Bleomycin - and Cisplatin-Based Treatment of Testicular_Cancer Patients and Relate to Endothelial Damage .
26564502	0	Growth_Differentiation_Factor_15	0,32	Matrix_Metalloproteinase_1	65,91	Growth Differentiation Factor 15	Matrix Metalloproteinase 1	9518	4312	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Growth_Differentiation_Factor_15 Inhibits Elevated Expression of Matrix_Metalloproteinase_1 Induced by Pooled Serum in Patients with Coroanry_Artery_Ectasia .
24348508	0	Growth_Hormone	10,24	Cystatin_C	28,38	Growth Hormone	Cystatin C	2688	1471	Gene	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of Growth_Hormone on Cystatin_C .
25459913	0	Growth_Hormone	134,148	DKK-1	70,75	Growth Hormone	DKK-1	2688	22943	Gene	Gene	Treatment|compound|START_ENTITY END_ENTITY|nmod|Treatment	Increased Serum and Bone Matrix Levels of the Secreted Wnt Antagonist DKK-1 in Patients With Growth_Hormone_Deficiency in Response to Growth_Hormone Treatment .
18406761	0	Growth_Hormone	0,14	Growth_Hormone	33,47	Growth Hormone	Growth Hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Growth_Hormone therapy for adult Growth_Hormone deficiency .
18406761	0	Growth_Hormone	33,47	Growth_Hormone	0,14	Growth Hormone	Growth Hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Growth_Hormone therapy for adult Growth_Hormone deficiency .
25341521	0	Growth_Hormone	13,27	IGF-1	28,33	Growth Hormone	IGF-1	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	Prevention|compound|START_ENTITY Prevention|dep|Pathways Pathways|amod|END_ENTITY	Conservative Growth_Hormone / IGF-1 and mTOR Signaling Pathways as a Target for Aging and Cancer Prevention : Do We Really Have an Antiaging Drug ?
25835289	0	Growth_Hormone	37,51	IGF-1	81,86	Growth Hormone	IGF-1	2688	3479	Gene	Gene	Studied|compound|START_ENTITY Modulation|nmod|Studied Modulation|nmod|Test Test|compound|END_ENTITY	Genetic and Epigenetic Modulation of Growth_Hormone Sensitivity Studied With the IGF-1 Generation Test .
25607339	0	Growth_Hormone	53,67	IGF-I	10,15	Growth Hormone	IGF-I	2688	3479	Gene	Gene	Therapy|compound|START_ENTITY Factor|nmod|Therapy Deficiency|nmod|Factor Deficiency|compound|END_ENTITY	Secondary IGF-I Deficiency as a Prognostic Factor of Growth_Hormone -LRB- GH -RRB- Therapy Effectiveness in Children with Isolated , Non-acquired GH_Deficiency .
25765099	0	Growth_Hormone	18,32	Insulin-Like_Growth_Factor-1	56,84	Growth hormone	Insulin-Like Growth Factor-1	2688	3479	Gene	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Recombinant Human Growth_Hormone Plus Recombinant Human Insulin-Like_Growth_Factor-1 Coadministration Therapy in Short Children with Low Insulin-Like_Growth_Factor-1 and Growth_Hormone Sufficiency : Results from a Randomized , Multicenter , Open-Label , Parallel-Group , Active Treatment-Controlled Trial .
7949595	1	Growth_Hormone	168,182	Insulin-like_Growth_Factor_I	126,154	Growth Hormone	Insulin-like Growth Factor I	2688	3479	Gene	Gene	Syndromes|compound|START_ENTITY Group|nmod|Syndromes Group|nmod|Treatment Treatment|compound|END_ENTITY	Pharmacia Study Group on Insulin-like_Growth_Factor_I Treatment in Growth_Hormone Insensitivity Syndromes .
25364551	0	Growth_Hormone	37,51	NR2B	64,68	Growth Hormone	NR2B	81668(Tax:10116)	24410(Tax:10116)	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	Co-Application of Corticosterone and Growth_Hormone Upregulates NR2B Protein and Increases the NR2B : NR2A Ratio and Synaptic Transmission in the Hippocampus .
21779476	0	Growth_Hormone	17,31	STAT5	75,80	Growth Hormone	STAT5	14599(Tax:10090)	20850(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Context-Specific Growth_Hormone Signaling through the Transcription Factor STAT5 : Implications for the Etiology of Hepatosteatosis_and_Hepatocellular_Carcinoma .
26913548	0	Growth_Hormone_Receptor	46,69	GHR	71,74	Growth Hormone Receptor	GHR	100009325(Tax:9986)	100009325(Tax:9986)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Identification of Polymorphisms in the Rabbit Growth_Hormone_Receptor -LRB- GHR -RRB- Gene and Association with Finishing Weight in a Commercial Meat Rabbit Line .
21551541	0	Growth_Inhibitory_Factor	22,46	MT-III	54,60	Growth Inhibitory Factor	MT-III	117038(Tax:10116)	117038(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Altered expression of Growth_Inhibitory_Factor -LRB- GIF / MT-III -RRB- mRNA in the rat facial nucleus after facial_nerve_injury is closely related with facial function .
20528846	0	Growth_and_Differentiation_Factor_9	26,61	GDF9	63,67	Growth and Differentiation Factor 9	GDF9	100217402(Tax:9940)	100217402(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new polymorphism in the Growth_and_Differentiation_Factor_9 -LRB- GDF9 -RRB- gene is associated with increased ovulation rate and prolificacy in homozygous sheep .
22907951	0	Growth_arrest-specific_gene_6	0,29	Gas6	31,35	Growth arrest-specific gene 6	Gas6	2621	2621	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Growth_arrest-specific_gene_6 -LRB- Gas6 -RRB- levels are elevated in patients with chronic_renal_failure .
9718977	0	Growth_associated_protein_43	0,28	GAP-43	30,36	Growth associated protein 43	GAP-43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Growth_associated_protein_43 -LRB- GAP-43 -RRB- mRNA is upregulated in the rat superior cervical ganglia after preganglionic transection .
25171167	0	Growth_differentiation_factor-15	0,32	GDF-15	34,40	Growth differentiation factor-15	GDF-15	9518	9518	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Growth_differentiation_factor-15 -LRB- GDF-15 -RRB- levels are associated with cardiac and renal_injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass .
22872134	0	Growth_differentiation_factor-15	0,32	interleukin-6	45,58	Growth differentiation factor-15	interleukin-6	9518	3569	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	Growth_differentiation_factor-15 upregulates interleukin-6 to promote tumorigenesis of prostate_carcinoma PC-3 cells .
12574210	0	Growth_differentiation_factor-9	0,31	Smad2	40,45	Growth differentiation factor-9	Smad2	2661	4087	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	Growth_differentiation_factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells .
16845371	0	Growth_differentiation_factor_11	0,32	ALK5	94,98	Growth differentiation factor 11	ALK5	14561(Tax:10090)	21812(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Growth_differentiation_factor_11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis .
21803025	0	Growth_differentiation_factor_15	0,32	HER2	50,54	Growth differentiation factor 15	HER2	9518	2064	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|compound|END_ENTITY	Growth_differentiation_factor_15 -LRB- GDF15 -RRB- - mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast_cancer cells .
8471538	0	Growth_factor	0,13	TGF-beta_3	65,75	Growth factor	TGF-beta 3	79215(Tax:10116)	25717(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	Growth_factor expression during rat development : a comparison of TGF-beta_3 , TGF-alpha , bFGF , PDGF and PDGF-R .
17156408	0	Growth_factor-independent_1B	0,28	GFI1B	35,40	Growth factor-independent 1B	GFI1B	8328	8328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Growth_factor-independent_1B gene -LRB- GFI1B -RRB- is overexpressed in erythropoietic and megakaryocytic malignancies and increases their proliferation rate .
20147447	0	Growth_factor_erv1-like	0,23	Drp1	34,38	Growth factor erv1-like	Drp1	11692(Tax:10090)	74006(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Growth_factor_erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells .
12049724	0	Growth_factor_independent-1	0,27	IL-4	39,43	Growth factor independent-1	IL-4	2672	3565	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Growth_factor_independent-1 induced by IL-4 regulates Th2 cell proliferation .
9670936	0	Growth_factor_receptor-bound_protein_2	0,38	Grb2	40,44	Growth factor receptor-bound protein 2	Grb2	14784(Tax:10090)	14784(Tax:10090)	Gene	Gene	association|amod|START_ENTITY association|appos|END_ENTITY	Growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- association with hemopoietic_specific_protein_1 : linkage between Lck and Grb2 .
9670936	0	Growth_factor_receptor-bound_protein_2	0,38	hemopoietic_specific_protein_1	63,93	Growth factor receptor-bound protein 2	hemopoietic specific protein 1	14784(Tax:10090)	15163(Tax:10090)	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- association with hemopoietic_specific_protein_1 : linkage between Lck and Grb2 .
22467218	0	Growth_hormone	0,14	BMP9	31,35	Growth hormone	BMP9	14599(Tax:10090)	12165(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Growth_hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells .
16481459	0	Growth_hormone	0,14	CA1	65,68	Growth hormone	CA1	81668(Tax:10116)	310218(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Growth_hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus .
12955026	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	2688	2688	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- status and body composition in normal ageing and in elderly adults with GH_deficiency .
1374019	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of gastric structure and function in the GH-deficient rat : up-regulation of intrinsic factor .
1385420	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- induction of tyrosine phosphorylation and activation of mitogen-activated_protein kinases in cells transfected with rat GH_receptor cDNA .
2082191	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of cytochrome P-450IIC12 , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , and GH_receptor messenger RNA expression in primary rat hepatocytes : a hormonal interplay with insulin , IGF-I , and thyroid hormone .
2491809	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing hormone by perifused pituitary cells from male , female , and testicular feminized rats .
3084533	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in children with subnormal integrated concentrations of GH .
3114296	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to a single intravenous injection of synthetic GH-releasing hormone in prepubertal children with growth_failure .
7093701	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- immunoreactivity in the rodent and primate CNS : distribution , characterization and presence posthypophysectomy .
8016152	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	binding|compound|START_ENTITY binding|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- binding and effects of GH analogs in transgenic_mice .
8185813	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of a rat serine_protease_inhibitor fusion gene in cells transfected with GH_receptor cDNA .
8374692	0	Growth_hormone	0,14	GH	68,70	Growth hormone	GH	2688	2688	Gene	Gene	START_ENTITY|dep|use use|nmod|END_ENTITY	Growth_hormone -LRB- GH -RRB- and adult bone remodeling : the potential use of GH in treatment of osteoporosis .
8459190	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	378781(Tax:9031)	378781(Tax:9031)	Gene	Gene	suppression|amod|START_ENTITY suppression|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- suppression of catecholamine turnover in the chicken hypothalamus : implications for GH autoregulation .
9186309	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing peptide-6 in patients with insulin-dependent_diabetes_mellitus .
9186816	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in short children : lack of correlation with endogenous nocturnal GH secretion .
9379123	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of submandibular gland structure and function in the GH-deficient rat : upregulation of haptocorrin .
9768681	0	Growth_hormone	0,14	GH	16,18	Growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- response to GH-releasing peptide-6 in type 1 diabetic patients with exaggerated GH-releasing hormone-stimulated GH secretion .
15638293	0	Growth_hormone	0,14	GHRH	138,142	Growth hormone	GHRH	2688	2691	Gene	Gene	peaks|amod|START_ENTITY peaks|dep|analysis analysis|nmod|variables variables|acl|provided provided|nmod|test test|compound|END_ENTITY	Growth_hormone -LRB- GH -RRB- peaks versus areas under the curve in the diagnosis of adult GH_deficiency : analysis of the variables provided by the GHRH + GHRP-6 test .
2889308	0	Growth_hormone	0,14	GHRH	51,55	Growth hormone	GHRH	2688	2691	Gene	Gene	START_ENTITY|dobj|responses responses|nmod|END_ENTITY	Growth_hormone responses to the releasing hormones GHRH and GnRH and the inhibitors somatostatin and bromocriptine in TRH-responsive and non-responsive acromegalics .
2911939	0	Growth_hormone	0,14	GHRH	38,42	Growth hormone	GHRH	2688	2691	Gene	Gene	responsiveness|nsubj|START_ENTITY responsiveness|xcomp|END_ENTITY	Growth_hormone -LRB- GH -RRB- responsiveness to GHRH in normal adults is not affected by short-term gonadal blockade .
7788012	0	Growth_hormone	0,14	GHRH	61,65	Growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- , insulin , clonidine and arginine after GHRH pretreatment in obese children : evidence of somatostatin increase ?
8959075	0	Growth_hormone	0,14	GHRH	27,31	Growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Growth_hormone response to GHRH , GHRP-6 and GHRH + GHRP-6 in patients with polycystic_ovary_syndrome .
9509075	0	Growth_hormone	0,14	GHRH	37,41	Growth hormone	GHRH	2688	2691	Gene	Gene	secretion|amod|START_ENTITY elicited|nsubj|secretion elicited|nmod|GHRP-6 GHRP-6|compound|END_ENTITY	Growth_hormone secretion elicited by GHRH , GHRP-6 or GHRH plus GHRP-6 in patients with microprolactinoma and macroprolactinoma before and after bromocriptine therapy .
16024298	0	Growth_hormone	0,14	IGF-1	49,54	Growth hormone	IGF-1	2688	3479	Gene	Gene	growth|amod|START_ENTITY growth|dep|factor-1 factor-1|appos|END_ENTITY	Growth_hormone and insulin-like growth factor-1 -LRB- IGF-1 -RRB- and their influence on cognitive aging .
18053120	0	Growth_hormone	0,14	IGF-1	83,88	Growth hormone	IGF-1	2688	3479	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|levels levels|compound|END_ENTITY	Growth_hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels .
19207031	0	Growth_hormone	0,14	IGF-1	78,83	Growth hormone	IGF-1	2688	3479	Gene	Gene	dose|amod|START_ENTITY associated|nsubjpass|dose associated|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Growth_hormone dose in growth_hormone-deficient adults is not associated with IGF-1 gene polymorphisms .
19619004	0	Growth_hormone	0,14	IGF-1	119,124	Growth hormone	IGF-1	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|bone_loss bone_loss|nmod|states states|nmod|insulin-like_growth_factor insulin-like_growth_factor|appos|END_ENTITY	Growth_hormone protects against ovariectomy-induced bone_loss in states of low circulating insulin-like_growth_factor -LRB- IGF-1 -RRB- .
20928887	0	Growth_hormone	0,14	IGF-1	77,82	Growth hormone	IGF-1	14599(Tax:10090)	3479	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|independent independent|nmod|production production|compound|END_ENTITY	Growth_hormone mediates pubertal skeletal development independent of hepatic IGF-1 production .
12898266	0	Growth_hormone	0,14	IGF-I	47,52	Growth hormone	IGF-I	2688	3479	Gene	Gene	substitution|amod|START_ENTITY substitution|acl|titrated titrated|xcomp|obtain obtain|dobj|levels levels|amod|END_ENTITY	Growth_hormone substitution titrated to obtain IGF-I levels in the physiological range in hypopituitary adults : effects upon dynamic strength , endurance and EMG .
1360928	0	Growth_hormone	0,14	IGF-I	88,93	Growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|receptor receptor|appos|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Growth_hormone and prolactin stimulate androgen receptor , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor levels in the prostate of immature rats .
15163339	0	Growth_hormone	0,14	IGF-I	16,21	Growth hormone	IGF-I	2688	3479	Gene	Gene	peritoneal_dialysis|advmod|START_ENTITY peritoneal_dialysis|nsubj|END_ENTITY	Growth_hormone , IGF-I and its binding proteins -LRB- IGFBP-1_and _ -3 -RRB- in adult uraemic patients undergoing peritoneal_dialysis and haemodialysis .
2082191	0	Growth_hormone	0,14	IGF-I	199,204	Growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|dep|interplay interplay|nmod|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of cytochrome P-450IIC12 , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , and GH_receptor messenger RNA expression in primary rat hepatocytes : a hormonal interplay with insulin , IGF-I , and thyroid hormone .
21846964	0	Growth_hormone	0,14	IGF-I	15,20	Growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Growth_hormone / IGF-I axis and growth_hormone receptor mutations in idiopathic short_stature .
26682747	0	Growth_hormone	0,14	IGF-I	35,40	Growth hormone	IGF-I	2688	3479	Gene	Gene	relates|nsubj|START_ENTITY relates|nsubj|response response|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- dose-dependent IGF-I response relates to pubertal height gain .
7528707	0	Growth_hormone	0,14	IGF-I	61,66	Growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- stimulates insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein _ -LRB- IGFBP -RRB- -2 gene expression in spleens of juvenile rats .
7564093	0	Growth_hormone	0,14	IGF-I	72,77	Growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	interact|nsubj|START_ENTITY interact|xcomp|regulate regulate|dobj|expressions expressions|nmod|END_ENTITY	Growth_hormone and nutrition interact to regulate expressions of kidney IGF-I and IGFBP mRNAs .
7711889	0	Growth_hormone	0,14	IGF-I	60,65	Growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- modulates insulin-like_growth_factor_I -LRB- IGF-I -RRB- and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats .
8262319	0	Growth_hormone	0,14	IGF-I	83,88	Growth hormone	IGF-I	2688	3479	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Growth_hormone induces resistance to the mitogenic action of insulin through local IGF-I .
8550769	0	Growth_hormone	0,14	IGF-I	189,194	Growth hormone	IGF-I	2688	3479	Gene	Gene	secretory|nsubj|START_ENTITY secretory|parataxis|induce induce|dobj|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- secretory dynamics in a case of acromegalic_gigantism associated with hyperprolactinemia : nonpulsatile secretion of GH may induce elevated insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 levels .
8824894	0	Growth_hormone	0,14	IGF-I	25,30	Growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Growth_hormone increases IGF-I , collagen I and collagen III gene expression in dwarf rat skeletal muscle .
9364353	0	Growth_hormone	0,14	IGF-I	110,115	Growth hormone	IGF-I	2688	3479	Gene	Gene	treatment|amod|START_ENTITY treatment|dep|effect effect|nmod|levels levels|amod|END_ENTITY	Growth_hormone treatment in growth_retarded children with end stage_renal_failure : effect on free/dissociable IGF-I levels .
9390955	0	Growth_hormone	0,14	IGF-I	15,20	Growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|maintains maintains|nsubj|exercise exercise|nummod|END_ENTITY	Growth_hormone / IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles .
8674850	0	Growth_hormone	0,14	IGFBP-3	49,56	Growth hormone	IGFBP-3	81668(Tax:10116)	24484(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- regulate IGFBP-3 gene expression in rat beta-cells .
2396672	0	Growth_hormone	0,14	IGF_I	26,31	Growth hormone	IGF I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Growth_hormone stimulates IGF_I gene expression in isolated rat renal collecting duct .
11145745	0	Growth_hormone	0,14	INS-1	73,78	Growth hormone	INS-1	2688	2305	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Growth_hormone - and prolactin-induced proliferation_of_insulinoma cells , INS-1 , depends on activation of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- .
12688541	0	Growth_hormone	0,14	Interleukin-1beta	34,51	Growth hormone	Interleukin-1beta	2688	3553	Gene	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|expression expression|amod|END_ENTITY	Growth_hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute_phase_protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3 .
8770909	0	Growth_hormone	0,14	JAK2	54,58	Growth hormone	JAK2	81668(Tax:10116)	24514(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Growth_hormone stimulates tyrosine phosphorylation of JAK2 and STAT5 , but not insulin_receptor_substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo .
9553131	0	Growth_hormone	0,14	JAK2	112,116	Growth hormone	JAK2	14599(Tax:10090)	16452(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
9886807	0	Growth_hormone	0,14	JAK2	58,62	Growth hormone	JAK2	81668(Tax:10116)	24514(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin_receptor substrates and Shc in rat tissues .
25693117	0	Growth_hormone	10,24	Klotho	56,62	Growth hormone	Klotho	2688	9365	Gene	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of Growth_hormone replacement therapy on soluble Klotho in patients with Growth_hormone_deficiency .
9275086	0	Growth_hormone	0,14	Pit-1	107,112	Growth hormone	Pit-1	14599(Tax:10090)	18736(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY independent|nsubj|expression independent|nmod|END_ENTITY	Growth_hormone expression in murine bone marrow cells is independent of the pituitary transcription factor Pit-1 .
9507023	0	Growth_hormone	0,14	SIRP	29,33	Growth hormone	SIRP	2688	140885	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Growth_hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association .
10433229	0	Growth_hormone	0,14	SOCS-2	29,35	Growth hormone	SOCS-2	81668(Tax:10116)	84607(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Growth_hormone regulation of SOCS-2 , SOCS-3 , and CIS messenger ribonucleic acid expression in the rat .
9430658	0	Growth_hormone	0,14	SOCS-3	73,79	Growth hormone	SOCS-3	14599(Tax:10090)	12702(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Growth_hormone preferentially induces the rapid , transient expression of SOCS-3 , a novel inhibitor of cytokine receptor signaling .
10050749	0	Growth_hormone	0,14	STAT5	98,103	Growth hormone	STAT5	2688	6776	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|action action|nmod|END_ENTITY	Growth_hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1alpha .
10752065	0	Growth_hormone	0,14	STAT5	31,36	Growth hormone	STAT5	81668(Tax:10116)	24918(Tax:10116)	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Growth_hormone pulse-activated STAT5 signalling : a unique regulatory mechanism governing sexual dimorphism of liver gene expression .
11145745	0	Growth_hormone	0,14	STAT5	105,110	Growth hormone	STAT5	2688	6776	Gene	Gene	cells|amod|START_ENTITY depends|nsubj|cells depends|nmod|activation activation|nmod|END_ENTITY	Growth_hormone - and prolactin-induced proliferation_of_insulinoma cells , INS-1 , depends on activation of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- .
12604355	0	Growth_hormone	0,14	STAT5	43,48	Growth hormone	STAT5	14599(Tax:10090)	20850(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|proteins proteins|nummod|END_ENTITY	Growth_hormone , but not insulin , activates STAT5 proteins in adipocytes in vitro and in vivo .
8702683	0	Growth_hormone	0,14	STAT5	64,69	Growth hormone	STAT5	14599(Tax:10090)	20850(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|association association|nmod|END_ENTITY	Growth_hormone promotes the association of transcription factor STAT5 with the growth_hormone receptor .
10537141	0	Growth_hormone	0,14	STAT5a	70,76	Growth hormone	STAT5a	81668(Tax:10116)	24918(Tax:10116)	Gene	Gene	maintains|nsubj|START_ENTITY maintains|dobj|activation activation|nmod|END_ENTITY	Growth_hormone , but not prolactin , maintains , low-level activation of STAT5a and STAT5b in female rat liver .
17287404	0	Growth_hormone	0,14	STAT5b	88,94	Growth hormone	STAT5b	2688	6777	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|mutation mutation|amod|END_ENTITY	Growth_hormone secretion and immunological function of a male patient with a homozygous STAT5b mutation .
17389811	0	Growth_hormone	0,14	STAT5b	125,131	Growth hormone	STAT5b	2688	6777	Gene	Gene	insensitivity|amod|START_ENTITY insensitivity|dep|mutation mutation|nmod|junction junction|nmod|gene gene|amod|END_ENTITY	Growth_hormone insensitivity and severe short_stature in siblings : a novel mutation at the exon 13-intron 13 junction of the STAT5b gene .
11311850	0	Growth_hormone	0,14	Stat5a	76,82	Growth hormone	Stat5a	2688	6776	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Growth_hormone induces tyrosyl phosphorylation of the transcription factors Stat5a and Stat5b in CMT-U335 canine mammary_tumor cells .
8621467	0	Growth_hormone	0,14	Stat_1	29,35	Growth hormone	Stat 1	81668(Tax:10116)	25124(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Growth_hormone activation of Stat_1 , Stat_3 , and Stat_5 in rat liver .
9862866	0	Growth_hormone	0,14	alpha-1-acid_glycoprotein	34,59	Growth hormone	alpha-1-acid glycoprotein	81668(Tax:10116)	24614(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Growth_hormone inhibits rat liver alpha-1-acid_glycoprotein gene expression in vivo and in vitro .
8828496	0	Growth_hormone	0,14	annexin_I	51,60	Growth hormone	annexin I	81668(Tax:10116)	25380(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Growth_hormone induces tyrosine phosphorylation of annexin_I in rat_osteosarcoma cells .
1396336	0	Growth_hormone	0,14	c-fos	64,69	Growth hormone	c-fos	2688	2353	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|advcl|inducing inducing|dobj|transcription transcription|amod|END_ENTITY	Growth_hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells .
1547725	0	Growth_hormone	0,14	c-fos	23,28	Growth hormone	c-fos	2688	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Growth_hormone induces c-fos and c-jun expression in cells with varying requirements for differentiation .
2493151	0	Growth_hormone	0,14	c-fos	26,31	Growth hormone	c-fos	2688	2353	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Growth_hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover .
7988469	0	Growth_hormone	0,14	c-fos	41,46	Growth hormone	c-fos	81668(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	Growth_hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats .
11014245	0	Growth_hormone	0,14	connexin-43	25,36	Growth hormone	connexin-43	81668(Tax:10116)	24392(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Growth_hormone increases connexin-43 expression in the cerebral cortex and hypothalamus .
3494447	0	Growth_hormone	0,14	cytochrome_P-450_15_beta	49,73	Growth hormone	cytochrome P-450 15 beta	81668(Tax:10116)	25011(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Growth_hormone regulates expression of rat liver cytochrome_P-450_15_beta at a pretranslational level .
1496921	0	Growth_hormone	0,14	cytochrome_P450	37,52	Growth hormone	cytochrome P450	81668(Tax:10116)	25251(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Growth_hormone regulation of hepatic cytochrome_P450 expression in the rat .
14675775	0	Growth_hormone	0,14	eNOS	23,27	Growth hormone	eNOS	2688	4846	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Growth_hormone induces eNOS expression and nitric_oxide release in a cultured human endothelial cell line .
2789066	0	Growth_hormone	0,14	epidermal_growth_factor_receptor	44,76	Growth hormone	epidermal growth factor receptor	81668(Tax:10116)	24329(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Growth_hormone regulates the rodent hepatic epidermal_growth_factor_receptor at a pretranslational level .
1361819	0	Growth_hormone	0,14	erythropoietin	111,125	Growth hormone	erythropoietin	2688	2056	Gene	Gene	responses|amod|START_ENTITY treated|nsubj|responses treated|nmod|END_ENTITY	Growth_hormone responses to pituitary and hypothalamic stimuli in CAPD patients treated with recombinant human erythropoietin .
7999845	0	Growth_hormone	0,14	erythropoietin	55,69	Growth hormone	erythropoietin	2688	2056	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Growth_hormone and cortisol secretion before and after erythropoietin therapy in CAPD patients .
9553131	0	Growth_hormone	0,14	focal_adhesion_kinase	79,100	Growth hormone	focal adhesion kinase	14599(Tax:10090)	14083(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
8843754	0	Growth_hormone	0,14	gastrin	27,34	Growth hormone	gastrin	14599(Tax:10090)	14459(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Growth_hormone upregulates gastrin and peptide_YY gene expression .
17993760	0	Growth_hormone	0,14	ghrelin	57,64	Growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Growth_hormone and somatostatin directly inhibit gastric ghrelin secretion .
23772680	0	Growth_hormone	0,14	ghrelin	42,49	Growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	treatment|amod|START_ENTITY modulates|nsubj|treatment modulates|dobj|levels levels|compound|END_ENTITY	Growth_hormone treatment modulates active ghrelin levels in rats .
1314998	0	Growth_hormone	0,14	growth_hormone	33,47	Growth hormone	growth hormone	2688	2688	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Growth_hormone response to acute growth_hormone releasing hormone administration in uraemic patients on haemodialysis .
1768809	0	Growth_hormone	0,14	growth_hormone	60,74	Growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|dep|use use|nmod|END_ENTITY	Growth_hormone and the kidney : the use of recombinant human growth_hormone -LRB- rhGH -RRB- in growth-retarded children with chronic_renal_insufficiency .
11251367	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	29,61	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|stimulation stimulation|amod|END_ENTITY	Growth_hormone response to a growth_hormone-releasing_hormone stimulation test in a population-based study following cranial irradiation of childhood brain_tumors .
14642012	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	27,59	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone and clonidine in young monkeys : correlation with behavioral characteristics .
15705990	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	27,59	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone is reduced in adult asthmatic patients receiving long-term inhaled corticosteroid treatment .
2126361	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	28,60	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nmod|hypoglycemia hypoglycemia|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone , clonidine and insulin-induced hypoglycemia in normal weight bulimic women .
2501967	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	37,69	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nmod|infusion infusion|amod|END_ENTITY	Growth_hormone response to overnight growth_hormone-releasing_hormone infusion and oral pyridostigmine in children with short_stature .
2513890	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	38,70	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	release|nsubj|START_ENTITY release|xcomp|END_ENTITY	Growth_hormone release in response to growth_hormone-releasing_hormone in term and preterm neonates .
2866496	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	28,60	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	responses|amod|START_ENTITY responses|acl|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone -LRB- 1-29 -RRB- - NH2 and a D-Ala2 analog in normal men .
3100110	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	58,90	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	pretreatment|amod|START_ENTITY pretreatment|nmod|END_ENTITY	Growth_hormone pretreatment in man blocks the response to growth_hormone-releasing_hormone ; evidence for a direct effect of growth_hormone .
3117453	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	38,70	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	hyperresponsiveness|nsubj|START_ENTITY hyperresponsiveness|xcomp|END_ENTITY	Growth_hormone hyperresponsiveness to growth_hormone-releasing_hormone in patients with severe liver_cirrhosis .
3144116	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	27,59	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- hp GHRH1-44 -RRB- as an index of growth_hormone secretory dysfunction after prophylactic cranial irradiation for acute_lymphoblastic_leukemia -LRB- 24 grays -RRB- .
3149734	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	29,61	Growth hormone	growth hormone-releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	START_ENTITY|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Growth_hormone regulation of growth_hormone-releasing_hormone gene expression .
3924946	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	52,84	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nmod|infusions infusions|nmod|END_ENTITY	Growth_hormone responses to continuous infusions of growth_hormone-releasing_hormone .
7761697	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	28,60	Growth hormone	growth hormone-releasing hormone	403795(Tax:9615)	485863(Tax:9615)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and clonidine in dogs with Cushing 's _ syndrome .
7788012	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	27,59	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- , insulin , clonidine and arginine after GHRH pretreatment in obese children : evidence of somatostatin increase ?
7926116	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	27,59	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone stimulation in oligozoospermic patients .
8136894	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	62,94	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY secretion|dep|studies studies|nmod|END_ENTITY	Growth_hormone secretion in Alzheimer 's _ disease : studies with growth_hormone-releasing_hormone alone and combined with pyridostigmine or arginine .
8762731	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	28,60	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and clonidine in patients with type_I_diabetes and in normal controls : effect of age , body mass index and sex .
8810733	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	27,59	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone varies with the hypothalamic-pituitary_abnormalities .
9518881	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	28,60	Growth hormone	growth hormone-releasing hormone	403795(Tax:9615)	485863(Tax:9615)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and hexarelin in fed and fasted dogs : effect of somatostatin infusion or pretreatment with pirenzepine .
9925180	0	Growth_hormone	0,14	growth_hormone-releasing_hormone	27,59	Growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone stimulation in obsessive-compulsive_disorder .
10996429	0	Growth_hormone	0,14	growth_hormone_receptor	25,48	Growth hormone	growth hormone receptor	2688	2690	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Growth_hormone regulates growth_hormone_receptor gene transcription in primary human thyroid cells .
2871950	0	Growth_hormone	0,14	growth_hormone_releasing_factor	62,93	Growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	START_ENTITY|nmod|dose dose|nmod|injections injections|nmod|END_ENTITY	Growth_hormone response to low dose intravenous injections of growth_hormone_releasing_factor in obese and normal weight women .
2893766	0	Growth_hormone	0,14	growth_hormone_releasing_factor	62,93	Growth hormone	growth hormone releasing factor	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY secretion|dep|effects effects|nmod|END_ENTITY	Growth_hormone secretion during pregnancy : altered effects of growth_hormone_releasing_factor and insulin-like_growth_factor-I in vitro .
1362733	0	Growth_hormone	0,14	growth_hormone_releasing_hormone	88,120	Growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	therapy|amod|START_ENTITY induces|nsubj|therapy induces|nmod|levels levels|compound|END_ENTITY	Growth_hormone therapy in normal short children induces a transitory decrease in plasma growth_hormone_releasing_hormone levels and in human growth_hormone responsiveness to exogenous growth_hormone_releasing_hormone .
2045623	0	Growth_hormone	0,14	growth_hormone_releasing_hormone	34,66	Growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|injection injection|amod|END_ENTITY	Growth_hormone response following growth_hormone_releasing_hormone injection in thalassemia major : influence of pubertal development .
3106789	0	Growth_hormone	1,15	growth_hormone_releasing_hormone	54,86	Growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	secretion|nsubj|START_ENTITY secretion|nmod|administration administration|nmod|END_ENTITY	-LSB- Growth_hormone secretion following administration of growth_hormone_releasing_hormone in constitutional short_stature and idiopathic growth_hormone deficiency -RSB- .
10533850	0	Growth_hormone	0,14	insulin	31,38	Growth hormone	insulin	2688	3630	Gene	Gene	START_ENTITY|nmod|tolerance tolerance|compound|END_ENTITY	Growth_hormone response to the insulin tolerance and clonidine tests in type 1 diabetes .
11883314	0	Growth_hormone	1,15	insulin	17,24	Growth hormone	insulin	2688	3630	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	-LSB- Growth_hormone , insulin , IGF-1 and estradiol levels during maturation of internal sex organs before and at menarche -RSB- .
2036727	0	Growth_hormone	0,14	insulin	46,53	Growth hormone	insulin	2688	3630	Gene	Gene	insulin-like_growth_factor|dep|START_ENTITY insulin-like_growth_factor|nmod|END_ENTITY	Growth_hormone , insulin-like_growth_factor I , insulin and C-peptide during human fetal life : in-utero study .
2202546	0	Growth_hormone	0,14	insulin	16,23	Growth hormone	insulin	443329(Tax:9940)	105613195	Gene	Gene	lambs|advmod|START_ENTITY lambs|nsubj|levels levels|compound|END_ENTITY	Growth_hormone , insulin , prolactin and glucose levels in ewe and ram lambs during normal and compensatory growth .
12868196	0	Growth_hormone	1,15	insulin-like_growth_factor	17,43	Growth hormone	insulin-like growth factor	2688	3479	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	-LSB- Growth_hormone , insulin-like_growth_factor and insulin-like_growth_factor binding protein in young type_I_diabetes patients with the onset of diabetic_angiopathy -RSB- .
10764896	0	Growth_hormone	0,14	insulin-like_growth_factor-1	16,44	Growth hormone	insulin-like growth factor-1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	factor|advmod|START_ENTITY factor|nsubj|END_ENTITY	Growth_hormone , insulin-like_growth_factor-1 , and the insulin-like growth factor binding proteins in rats maintaining reduced body protein following lesions of the lateral_hypothalamus .
10556786	0	Growth_hormone	0,14	insulin-like_growth_factor-I	73,101	Growth hormone	insulin-like growth factor-I	443329(Tax:9940)	443318(Tax:9940)	Gene	Gene	supply|amod|START_ENTITY supply|amod|interact interact|xcomp|control control|dobj|production production|amod|END_ENTITY	Growth_hormone and amino_acid supply interact synergistically to control insulin-like_growth_factor-I production and gene expression in cultured ovine hepatocytes .
1360928	0	Growth_hormone	0,14	insulin-like_growth_factor-I	58,86	Growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|receptor receptor|appos|END_ENTITY	Growth_hormone and prolactin stimulate androgen receptor , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor levels in the prostate of immature rats .
2918262	0	Growth_hormone	0,14	insulin-like_growth_factor-I	38,66	Growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|level level|nmod|mRNA mRNA|compound|END_ENTITY	Growth_hormone regulates the level of insulin-like_growth_factor-I mRNA in rat skeletal muscle .
7528707	0	Growth_hormone	0,14	insulin-like_growth_factor-I	31,59	Growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Growth_hormone -LRB- GH -RRB- stimulates insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein _ -LRB- IGFBP -RRB- -2 gene expression in spleens of juvenile rats .
8070383	0	Growth_hormone	0,14	insulin-like_growth_factor-I	86,114	Growth hormone	insulin-like growth factor-I	100356068(Tax:9986)	100008668(Tax:9986)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|stimulating stimulating|dobj|production production|nmod|END_ENTITY	Growth_hormone stimulates follicular development by stimulating ovarian production of insulin-like_growth_factor-I .
8173015	0	Growth_hormone	0,14	insulin-like_growth_factor-I	16,44	Growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	neonates|advmod|START_ENTITY neonates|nsubj|END_ENTITY	Growth_hormone , insulin-like_growth_factor-I and prolactin in small for gestational age neonates .
8550769	0	Growth_hormone	0,14	insulin-like_growth_factor-I	159,187	Growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	secretory|nsubj|START_ENTITY secretory|parataxis|induce induce|dobj|END_ENTITY	Growth_hormone -LRB- GH -RRB- secretory dynamics in a case of acromegalic_gigantism associated with hyperprolactinemia : nonpulsatile secretion of GH may induce elevated insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 levels .
9283129	0	Growth_hormone	0,14	insulin-like_growth_factor-I	35,63	Growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nsubj|secretion	Growth_hormone secretion and serum insulin-like_growth_factor-I concentration in X-linked_hypophosphatemic_rickets before and after treatment .
10453940	0	Growth_hormone	0,14	insulin-like_growth_factor_1	15,43	Growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	START_ENTITY|parataxis|contribute contribute|nsubj|alterations alterations|amod|END_ENTITY	Growth_hormone / insulin-like_growth_factor_1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy .
15108263	0	Growth_hormone	0,14	insulin-like_growth_factor_1	15,43	Growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	recovery|compound|START_ENTITY recovery|amod|END_ENTITY	Growth_hormone / insulin-like_growth_factor_1 axis recovery after liver transplantation : a preliminary prospective study .
16670201	0	Growth_hormone	0,14	insulin-like_growth_factor_1	67,95	Growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|independent independent|nmod|up-regulation up-regulation|amod|END_ENTITY	Growth_hormone promotes skeletal muscle cell fusion independent of insulin-like_growth_factor_1 up-regulation .
24889799	0	Growth_hormone	0,14	insulin-like_growth_factor_1	15,43	Growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	START_ENTITY|parataxis|transplantation transplantation|nsubj|dynamics dynamics|amod|END_ENTITY	Growth_hormone / insulin-like_growth_factor_1 dynamics in adult living donor liver transplantation .
1480177	0	Growth_hormone	0,14	insulin-like_growth_factor_I	33,61	Growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Growth_hormone rapidly activates insulin-like_growth_factor_I gene transcription in vivo .
2738797	0	Growth_hormone	0,14	insulin-like_growth_factor_I	53,81	Growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY impedes|nsubj|deficiency impedes|dobj|rise rise|nmod|levels levels|compound|END_ENTITY	Growth_hormone deficiency impedes the rise in plasma insulin-like_growth_factor_I levels associated with precocious_puberty .
2918420	0	Growth_hormone	0,14	insulin-like_growth_factor_I	26,54	Growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|actions actions|compound|END_ENTITY	Growth_hormone stimulates insulin-like_growth_factor_I actions on adult articular chondrocytes .
3654912	0	Growth_hormone	0,14	insulin-like_growth_factor_I	82,110	Growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	treatment|amod|START_ENTITY treatment|dep|relationship relationship|nmod|END_ENTITY	Growth_hormone treatment in short children : relationship between growth and serum insulin-like_growth_factor_I and II levels .
3755433	0	Growth_hormone	0,14	insulin-like_growth_factor_I	42,70	Growth hormone	insulin-like growth factor I	81668(Tax:10116)	3479	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|abundance abundance|nmod|RNA RNA|compound|END_ENTITY	Growth_hormone regulates the abundance of insulin-like_growth_factor_I RNA in adult rat liver .
7556882	0	Growth_hormone	0,14	insulin-like_growth_factor_I	25,53	Growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	amplifies|amod|START_ENTITY END_ENTITY|nsubj|amplifies	Growth_hormone amplifies insulin-like_growth_factor_I induced progesterone accumulation and P450scc mRNA expression .
7711889	0	Growth_hormone	0,14	insulin-like_growth_factor_I	30,58	Growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Growth_hormone -LRB- GH -RRB- modulates insulin-like_growth_factor_I -LRB- IGF-I -RRB- and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats .
9437510	0	Growth_hormone	0,14	insulin-like_growth_factor_I	85,113	Growth hormone	insulin-like growth factor I	100356068(Tax:9986)	100008668(Tax:9986)	Gene	Gene	effects|amod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Growth_hormone stimulatory effects on osteoclastic resorption are partly mediated by insulin-like_growth_factor_I : an in vitro study .
9589657	0	Growth_hormone	0,14	insulin-like_growth_factor_I	50,78	Growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	treatment|amod|START_ENTITY prevents|nsubj|treatment prevents|dobj|decrease decrease|nmod|expression expression|amod|END_ENTITY	Growth_hormone treatment prevents the decrease in insulin-like_growth_factor_I gene expression in patients undergoing abdominal surgery .
8905638	0	Growth_hormone	0,14	insulin-like_growth_factor_binding_protein-2	43,87	Growth hormone	insulin-like growth factor binding protein-2	443329(Tax:9940)	443469(Tax:9940)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Growth_hormone stimulates the secretion of insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- by monolayer cultures of sheep costal growth plate chondrocytes .
7693512	0	Growth_hormone	0,14	insulin-like_growth_factor_binding_protein-3	92,136	Growth hormone	insulin-like growth factor binding protein-3	81668(Tax:10116)	24484(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|nmod|END_ENTITY	Growth_hormone , but not insulin-like growth factor I , induces a serum protease activity for insulin-like_growth_factor_binding_protein-3 in hypophysectomized rats in vivo .
9195204	0	Growth_hormone	0,14	interferon-gamma	40,56	Growth hormone	interferon-gamma	2688	3458	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Growth_hormone stimulates production of interferon-gamma by human peripheral mononuclear cells .
9326741	0	Growth_hormone	0,14	interferon_gamma	23,39	Growth hormone	interferon gamma	2688	3458	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Growth_hormone induces interferon_gamma production and may play a role in the presentation of alloantigens in vitro .
9110153	0	Growth_hormone	0,14	interleukin-1_alpha	26,45	Growth hormone	interleukin-1 alpha	14599(Tax:10090)	16175(Tax:10090)	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Growth_hormone release of interleukin-1_alpha , interferon-gamma and interleukin-4 from murine splenocytes stimulated with staphylococcal protein A , toxic_shock_syndrome toxin-1 and streptococcal lysin S .
8954036	0	Growth_hormone	0,14	interleukin-6	25,38	Growth hormone	interleukin-6	2688	3569	Gene	Gene	increases|amod|START_ENTITY increases|amod|END_ENTITY	Growth_hormone increases interleukin-6 produced by human osteoblast-like cells .
21321317	0	Growth_hormone	0,14	intestinal_trefoil_factor	27,52	Growth hormone	intestinal trefoil factor	81668(Tax:10116)	25563(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Growth_hormone upregulates intestinal_trefoil_factor expression in the ileum of rats after y-radiation .
10333553	0	Growth_hormone	0,14	leptin	33,39	Growth hormone	leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Growth_hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats .
10681635	0	Growth_hormone	0,14	leptin	45,51	Growth hormone	leptin	2688	3952	Gene	Gene	downregulates|amod|START_ENTITY serum|nsubj|downregulates serum|dobj|levels levels|compound|END_ENTITY	Growth_hormone treatment downregulates serum leptin levels in children independent of changes in body mass index .
12759574	0	Growth_hormone	0,14	low-density_lipoprotein_receptor	25,57	Growth hormone	low-density lipoprotein receptor	14599(Tax:10090)	16835(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Growth_hormone increases low-density_lipoprotein_receptor and HMG-CoA_reductase mRNA expression in mesangial cells .
8637440	0	Growth_hormone	0,14	low-density_lipoprotein_receptor	26,58	Growth hormone	low-density lipoprotein receptor	81668(Tax:10116)	300438(Tax:10116)	Gene	Gene	normalizes|nsubj|START_ENTITY normalizes|dobj|expression expression|amod|END_ENTITY	Growth_hormone normalizes low-density_lipoprotein_receptor gene expression in hypothyroid rats .
18772608	0	Growth_hormone	0,14	mechano_growth_factor	26,47	Growth hormone	mechano growth factor	14599(Tax:10090)	17311(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Growth_hormone stimulates mechano_growth_factor expression and activates myoblast transformation in C2C12 cells .
9790225	0	Growth_hormone	0,14	neuropeptide_Y	97,111	Growth hormone	neuropeptide Y	81668(Tax:10116)	24604(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|acting acting|nmod|neurons neurons|amod|END_ENTITY	Growth_hormone inhibits its own secretion by acting on the hypothalamus through its receptors on neuropeptide_Y neurons in the arcuate_nucleus and somatostatin neurons in the periventricular nucleus .
17332531	0	Growth_hormone	0,14	osteoprotegerin	26,41	Growth hormone	osteoprotegerin	2688	4982	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Growth_hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells .
17363744	0	Growth_hormone	0,14	p85alpha	29,37	Growth hormone	p85alpha	14599(Tax:10090)	18708(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Growth_hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue : mechanism for growth_hormone-mediated insulin resistance .
15380861	0	Growth_hormone	0,14	prolactin	78,87	Growth hormone	prolactin	2688	5617	Gene	Gene	responses|compound|START_ENTITY responses|dep|response response|compound|END_ENTITY	Growth_hormone , cortisol and prolactin responses to physical exercise : higher prolactin response in depressed patients .
4030438	0	Growth_hormone	0,14	prolactin	79,88	Growth hormone	prolactin	2688	5617	Gene	Gene	pituitary_adenomas|amod|START_ENTITY pituitary_adenomas|nmod|hypersecretion hypersecretion|nmod|END_ENTITY	Growth_hormone producing pituitary_adenomas with concomitant hypersecretion of prolactin are particularly sensitive to photon irradiation .
6777767	0	Growth_hormone	0,14	prolactin	16,25	Growth hormone	prolactin	2688	5617	Gene	Gene	START_ENTITY|dobj|responses responses|compound|END_ENTITY	Growth_hormone , prolactin and thyrotrophin responses to thyrotrophin-releasing_hormone in diabetic patients .
2293027	0	Growth_hormone	0,14	prolactin_receptor	85,103	Growth hormone	prolactin receptor	81668(Tax:10116)	24684(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Growth_hormone pretranslationally regulates the sexually dimorphic expression of the prolactin_receptor gene in rat liver .
7788012	0	Growth_hormone	0,14	somatostatin	155,167	Growth hormone	somatostatin	2688	6750	Gene	Gene	response|amod|START_ENTITY response|dep|evidence evidence|nmod|increase increase|compound|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- , insulin , clonidine and arginine after GHRH pretreatment in obese children : evidence of somatostatin increase ?
9518881	0	Growth_hormone	0,14	somatostatin	109,121	Growth hormone	somatostatin	403795(Tax:9615)	403993(Tax:9615)	Gene	Gene	responses|amod|START_ENTITY responses|dep|effect effect|nmod|infusion infusion|compound|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and hexarelin in fed and fasted dogs : effect of somatostatin infusion or pretreatment with pirenzepine .
9915797	1	Growth_hormone	177,191	stat5b	253,259	Growth hormone	stat5b	2688	6777	Gene	Gene	inhibition|amod|START_ENTITY mediated|nsubj|inhibition mediated|nmod|END_ENTITY	Growth_hormone inhibition of pparalpha transcriptional activity mediated by stat5b .
10098503	0	Growth_hormone	0,14	steroidogenic_acute_regulatory_protein	25,63	Growth hormone	steroidogenic acute regulatory protein	81668(Tax:10116)	25557(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Growth_hormone regulates steroidogenic_acute_regulatory_protein expression and steroidogenesis in Leydig cell progenitors .
1398470	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	27,56	Growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in acromegalic patients : reproducibility and dose-response study .
3096046	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	27,56	Growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in children and adolescents : a reappraisal .
3135504	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	36,65	Growth hormone	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	secretion|amod|START_ENTITY secretion|acl|induced induced|nmod|END_ENTITY	Growth_hormone secretion induced by thyrotropin-releasing_hormone in adult chickens : evidence of dose-dependent induction of either refractoriness or sensitization .
3924582	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	27,56	Growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in the urethane-anesthetized rat : effect of thyroid status .
404131	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	37,66	Growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	START_ENTITY|xcomp|releasing releasing|dobj|activity activity|nmod|END_ENTITY	Growth_hormone releasing activity of thyrotropin-releasing_hormone in rats with hypothalamic_lesions .
6128295	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	27,56	Growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in liver cirrhosis : unique alteration in anterior pituitary responsiveness to hypothalamic hormones .
6401755	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	27,56	Growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	START_ENTITY|nmod|tests tests|amod|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone and oral glucose-loading tests in tall children and adolescents .
6769068	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	27,56	Growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|nmod|stimulation stimulation|amod|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone and gonadotropin-releasing_hormone stimulation in heroin addicts .
6780591	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	80,109	Growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	status|amod|START_ENTITY determinant|nsubj|status determinant|acl|END_ENTITY	Growth_hormone secretory status is a determinant of the thyrotropin response to thyrotropin-releasing_hormone in euthyroid patients with hypothalamic-pituitary_disease .
803976	0	Growth_hormone	0,14	thyrotropin-releasing_hormone	56,85	Growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	release|nsubj|START_ENTITY release|nmod|injection injection|nmod|END_ENTITY	Growth_hormone and prolactin release after injection of thyrotropin-releasing_hormone in patients with depression .
1620073	0	Growth_hormone	1,15	thyrotropin_releasing_hormone	63,92	Growth hormone	thyrotropin releasing hormone	2688	7200	Gene	Gene	secretion|nsubj|START_ENTITY secretion|nmod|administration administration|nmod|END_ENTITY	-LSB- Growth_hormone secretion in response to the administration of thyrotropin_releasing_hormone -LRB- TRH -RRB- in children with insulin-dependent_diabetes_mellitus -RSB- .
8325956	0	Growth_hormone-binding_protein	0,30	GH-BP	32,37	Growth hormone-binding protein	GH-BP	2690	2690	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Growth_hormone-binding_protein -LRB- GH-BP -RRB- levels in follicular fluid from human preovulatory follicles : correlation with serum GH-BP levels .
3135482	0	Growth_hormone-releasing_factor	0,31	c-fos	40,45	Growth hormone-releasing factor	c-fos	2691	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Growth_hormone-releasing_factor induces c-fos expression in cultured primary pituitary cells .
6424119	0	Growth_hormone-releasing_factor	0,31	growth_hormone	42,56	Growth hormone-releasing factor	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|mRNA mRNA|amod|END_ENTITY	Growth_hormone-releasing_factor regulates growth_hormone mRNA in primary cultures of rat pituitary cells .
6436973	0	Growth_hormone-releasing_factor	0,31	growth_hormone	51,65	Growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Growth_hormone-releasing_factor : direct effects on growth_hormone , glucose , and behavior via the brain .
2893728	0	Growth_hormone-releasing_factor	0,31	somatostatin	70,82	Growth hormone-releasing factor	somatostatin	29446(Tax:10116)	24797(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Growth_hormone-releasing_factor and fibroblast growth factor regulate somatostatin gene expression .
12538852	0	Growth_hormone-releasing_hormone	0,32	GHRH	34,38	Growth hormone-releasing hormone	GHRH	2691	2691	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Growth_hormone-releasing_hormone -LRB- GHRH -RRB- antagonists inhibit the proliferation of androgen-dependent and - independent prostate_cancers .
10461024	0	Growth_hormone-releasing_hormone	0,32	growth_hormone	56,70	Growth hormone-releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	attenuate|amod|START_ENTITY END_ENTITY|nsubj|attenuate	Growth_hormone-releasing_hormone and morphine attenuate growth_hormone secretagogue-induced activation of the arcuate nucleus in the male rat .
11572322	0	Growth_hormone-releasing_hormone	0,32	growth_hormone	109,123	Growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	combined|nsubj|START_ENTITY combined|nmod|secretagogues secretagogues|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Growth_hormone-releasing_hormone combined with arginine or growth_hormone secretagogues for the diagnosis of growth_hormone deficiency in adults .
3092819	0	Growth_hormone-releasing_hormone	0,32	growth_hormone	73,87	Growth hormone-releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|dep|stimulate stimulate|dobj|biosynthesis biosynthesis|nmod|END_ENTITY	Growth_hormone-releasing_hormone and clonidine stimulate biosynthesis of growth_hormone in neonatal pituitaries .
3096037	0	Growth_hormone-releasing_hormone	0,32	growth_hormone	67,81	Growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Growth_hormone-releasing_hormone in the diagnosis and treatment of growth_hormone deficient children .
3134650	0	Growth_hormone-releasing_hormone	0,32	growth_hormone	92,106	Growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|dep|studies studies|nmod|subjects subjects|nmod|disorders disorders|nmod|secretion secretion|amod|END_ENTITY	Growth_hormone-releasing_hormone : studies in normal subjects and patients with disorders of growth_hormone secretion .
7932284	0	Growth_hormone-releasing_hormone	0,32	growth_hormone	96,110	Growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Growth_hormone-releasing_hormone -LRB- GHRH -RRB- - induced effects on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression .
9238854	0	Growth_hormone-releasing_hormone	0,32	growth_hormone	103,117	Growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|dep|enhance enhance|dobj|secretion secretion|amod|END_ENTITY	Growth_hormone-releasing_hormone and growth_hormone-releasing_peptide as therapeutic agents to enhance growth_hormone secretion in disease and aging .
16432002	0	Growth_hormone_1	0,16	GH1	18,21	Growth hormone 1	GH1	2688	2688	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Growth_hormone_1 -LRB- GH1 -RRB- gene and performance and post-race rectal temperature during the South African Ironman triathlon .
23696513	0	Growth_hormone_receptor	0,23	GHR	25,28	Growth hormone receptor	GHR	2690	2690	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Growth_hormone_receptor -LRB- GHR -RRB- gene polymorphism and Prader-Willi_syndrome .
6130528	0	Growth_hormone_releasing_factor	0,31	growth_hormone	66,80	Growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	releases|nsubj|START_ENTITY releases|xcomp|END_ENTITY	Growth_hormone_releasing_factor , somatocrinin , releases pituitary growth_hormone in vitro .
3092193	0	Growth_hormone_releasing_hormone	0,32	gastrin	59,66	Growth hormone releasing hormone	gastrin	29446(Tax:10116)	25320(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Growth_hormone_releasing_hormone stimulates the release of gastrin in rat .
2840597	0	Growth_hormone_releasing_hormone	0,32	growth_hormone	52,66	Growth hormone releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Growth_hormone_releasing_hormone induced release of growth_hormone in aging male rats : dependence on pharmacological manipulation and endogenous somatostatin release .
3111168	0	Growth_hormone_releasing_hormone	0,32	growth_hormone	78,92	Growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nmod|treatment treatment|nmod|deficiency deficiency|amod|END_ENTITY	Growth_hormone_releasing_hormone in the assessment and long-term treatment of growth_hormone deficiency .
3923425	0	Growth_hormone_releasing_hormone	0,32	growth_hormone	81,95	Growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|dep|studies studies|nmod|deficiency deficiency|compound|END_ENTITY	Growth_hormone_releasing_hormone and growth_hormone : genetic studies in familial growth_hormone deficiency .
8319372	0	Growth_hormone_releasing_hormone	0,32	growth_hormone	51,65	Growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Growth_hormone_releasing_hormone priming increases growth_hormone secretion in patients with Cushing 's _ syndrome .
21323861	0	Grp94	111,116	HSP90	16,21	Grp94	HSP90	7184	3320	Gene	Gene	glucose-regulated_protein94|appos|START_ENTITY effect|nmod|glucose-regulated_protein94 promotion|nmod|effect END_ENTITY|nmod|promotion	Crucial role of HSP90 in the Akt-dependent promotion of angiogenic-like effect of glucose-regulated_protein94 -LRB- Grp94 -RRB- - IgG complexes .
19554567	0	Grp94	0,5	Hsp90	89,94	Grp94	Hsp90	22027(Tax:10090)	855836(Tax:4932)	Gene	Gene	has|nsubj|START_ENTITY has|nmod|END_ENTITY	Grp94 , the endoplasmic reticulum Hsp90 , has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide .
26872972	0	Grp94	99,104	Hsp90	54,59	Grp94	Hsp90	7184	3320	Gene	Gene	94|appos|START_ENTITY Regulates|nsubj|94 Regulates|dep|END_ENTITY	Endoplasmic Reticulum Resident Heat_Shock_Protein_90 -LRB- Hsp90 -RRB- Isoform Glucose-Regulated Protein 94 -LRB- Grp94 -RRB- Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport .
10209041	0	GrpL	0,4	SLP-76	53,59	GrpL	SLP-76	9402	3937	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	GrpL , a Grb2-related_adaptor_protein , interacts with SLP-76 to regulate nuclear factor of activated T cell activation .
9819356	0	Grr1	25,29	Cln2	53,57	Grr1	Cln2	853552(Tax:4932)	855819(Tax:4932)	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	An essential function of Grr1 for the degradation of Cln2 is to act as a binding core that links Cln2 to Skp1 .
15775961	0	Grr1	27,31	Hof1	15,19	Grr1	Hof1	853552(Tax:4932)	855048(Tax:4932)	Gene	Gene	Degradation|appos|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of Hof1 by SCF -LRB- Grr1 -RRB- is important for actomyosin contraction during cytokinesis in yeast .
9491072	0	Grr1	0,4	ubiquitin	22,31	Grr1	ubiquitin	853552(Tax:4932)	850620(Tax:4932)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Grr1 functions in the ubiquitin pathway in Saccharomyces_cerevisiae through association with Skp1 .
17961515	0	Grx2	87,91	glutaredoxin	73,85	Grx2	glutaredoxin	69367(Tax:10090)	69367(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive expression and functional characterization of mitochondrial glutaredoxin -LRB- Grx2 -RRB- in mouse and human brain .
17514647	0	Gs_alpha	0,8	Gs_alpha	36,44	Gs alpha	Gs alpha	2778	2778	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|END_ENTITY	Gs_alpha overexpression and loss of Gs_alpha imprinting in human somatotroph_adenomas : association with tumor size and response to pharmacologic treatment .
17514647	0	Gs_alpha	36,44	Gs_alpha	0,8	Gs alpha	Gs alpha	2778	2778	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|compound|END_ENTITY	Gs_alpha overexpression and loss of Gs_alpha imprinting in human somatotroph_adenomas : association with tumor size and response to pharmacologic treatment .
9272575	0	Gs_alpha	43,51	beta_2-adrenergic_receptor	16,42	Gs alpha	beta 2-adrenergic receptor	2778	154	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Activation of a beta_2-adrenergic_receptor / Gs_alpha fusion protein elicits a desensitization-resistant cAMP signal capable of inhibiting proliferation of two cancer cell lines .
11836449	0	Gsalpha	43,50	GNAS1	36,41	Gsalpha	GNAS1	2778	2778	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	An R201H activating mutation of the GNAS1 -LRB- Gsalpha -RRB- gene in a corticotroph pituitary adenoma .
12656668	0	Gsalpha	49,56	GNAS1	58,63	Gsalpha	GNAS1	2778	2778	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new heterozygous mutation -LRB- L338N -RRB- in the human Gsalpha -LRB- GNAS1 -RRB- gene as a cause for congenital_hypothyroidism in Albright 's _ hereditary_osteodystrophy .
17568773	0	Gsc	15,18	Foxh1	0,5	Gsc	Foxh1	14836(Tax:10090)	14106(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development .
10822263	0	Gscl	98,102	Rnf4	0,4	Gscl	Rnf4	195333(Tax:10090)	19822(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rnf4 , a RING protein expressed in the developing nervous and reproductive systems , interacts with Gscl , a gene within the DiGeorge critical region .
17322895	0	Gsk3_beta	64,73	Hdac2	0,5	Gsk3 beta	Hdac2	56637(Tax:10090)	15182(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY modulating|dobj|activity regulates|advcl|modulating regulates|nsubj|END_ENTITY	Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3_beta activity .
17608927	0	Gsk3beta	46,54	c-Jun_N-terminal_kinase	0,23	Gsk3beta	c-Jun N-terminal kinase	2932	5599	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	c-Jun_N-terminal_kinase -LRB- JNK -RRB- cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability .
18245335	0	GstD1	123,128	glutathione_S-transferase	91,116	GstD1	glutathione S-transferase	41503(Tax:7227)	48337(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The molecular basis of host adaptation in cactophilic Drosophila : molecular evolution of a glutathione_S-transferase gene -LRB- GstD1 -RRB- in Drosophila_mojavensis .
22174645	0	GstI	53,57	Glutathione_Transferase	23,46	GstI	Glutathione Transferase	542366(Tax:4577)	542366(Tax:4577)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Expression patterns of Glutathione_Transferase Gene -LRB- GstI -RRB- in maize seedlings under juglone-induced oxidative stress .
11991805	0	Gsta1	138,143	glutathione_S-transferase	112,137	Gsta1	glutathione S-transferase	14857(Tax:10090)	54486(Tax:10090)	Gene	Gene	Gstm3|compound|START_ENTITY Gstm3|compound|END_ENTITY	Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione_S-transferase Gsta1 , Gsta2 , Gstm1 , Gstm2 , Gstm3 and Gstm4 genes in the livers of male and female mice .
19701760	0	Gstt1	50,55	glutathione-S-transferase	4,29	Gstt1	glutathione-S-transferase	2952	373156	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|amod|END_ENTITY	The glutathione-S-transferase gene polymorphisms -LRB- Gstt1 , Gstm1 , and Gstp1 -RRB- in patients with non-allergic_nasal_polyposis .
9521869	0	Gtf2i	26,31	GTF2I	54,59	Gtf2i	GTF2I	14886(Tax:10090)	2969	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	A mouse single-copy gene , Gtf2i , the homolog of human GTF2I , that is duplicated in the Williams-Beuren_syndrome deletion region .
25681130	0	Guanfu_Base_A	0,13	CYP2D6	68,74	Guanfu Base A	CYP2D6	2673	1565	Gene	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|compound|END_ENTITY	Guanfu_Base_A , an Antiarrhythmic Alkaloid of Aconitum Coreanum Is A CYP2D6 Inhibitor of Human , Monkey , and Dog Isoforms .
22301607	0	Guanine-nucleotide_exchange_factor_H1	0,37	interleukin_6	74,87	Guanine-nucleotide exchange factor H1	interleukin 6	9181	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Guanine-nucleotide_exchange_factor_H1 mediates lipopolysaccharide-induced interleukin_6 and tumor_necrosis_factor_a expression in endothelial cells via activation of nuclear factor kB .
19079332	0	Guanylate-binding_protein-1	0,27	interferon-gamma	106,122	Guanylate-binding protein-1	interferon-gamma	2633	3458	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Guanylate-binding_protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-gamma and regulates barrier function through effects on apoptosis .
9344659	0	Guca1b	22,28	uroguanylin	4,15	Guca1b	uroguanylin	107477(Tax:10090)	14916(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The uroguanylin gene -LRB- Guca1b -RRB- is linked to guanylin -LRB- Guca2 -RRB- on mouse chromosome 4 .
23127433	0	Gurken	88,94	EGFR	10,14	Gurken	EGFR	34171(Tax:7227)	37455(Tax:7227)	Gene	Gene	trafficking|amod|START_ENTITY requires|dobj|trafficking requires|nsubj|signaling signaling|compound|END_ENTITY	Efficient EGFR signaling and dorsal-ventral_axis patterning requires syntaxin dependent Gurken trafficking .
11866425	0	Gurken	0,6	Egfr	122,126	Gurken	Egfr	34171(Tax:7227)	37455(Tax:7227)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Gurken , a TGF-alpha-like protein involved in axis_determination in Drosophila , directly binds to the EGF-receptor homolog Egfr .
12807768	0	Gyp2p	76,81	Rcy1p	36,41	Gyp2p	Rcy1p	852992(Tax:4932)	853226(Tax:4932)	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Opposite roles of the F-box protein Rcy1p and the GTPase-activating protein Gyp2p during recycling of internalized proteins in yeast .
20430893	0	Gys2	102,106	CLOCK	0,5	Gys2	CLOCK	2998	9575	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2 .
24258790	0	Gys2	30,34	glycogen_synthase_2	4,23	Gys2	glycogen synthase 2	2998	2998	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The glycogen_synthase_2 gene -LRB- Gys2 -RRB- displays parallel evolution between Old World and New World fruit bats .
1748486	0	H-2	35,38	Abp	39,42	H-2	Abp	111364(Tax:10090)	11354(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Structure function analysis of the H-2 Abp gene .
15621581	0	H-2	105,108	H-2	117,120	H-2	H-2	111364(Tax:10090)	111364(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Experimental autoimmune_thyroiditis -LRB- EAT -RRB- induced by the thyroglobulin peptide -LRB- 2596-2608 -RRB- : influence of H-2 and non H-2 genes .
15621581	0	H-2	117,120	H-2	105,108	H-2	H-2	111364(Tax:10090)	111364(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Experimental autoimmune_thyroiditis -LRB- EAT -RRB- induced by the thyroglobulin peptide -LRB- 2596-2608 -RRB- : influence of H-2 and non H-2 genes .
6145315	0	H-2	104,107	Thy-1_antigen	155,168	H-2	Thy-1 antigen	111364(Tax:10090)	21838(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Productive murine leukemia virus -LRB- MuLV -RRB- infection of EL4 T-lymphoblastoid cells : selective elevation of H-2 surface expression and possible association of Thy-1_antigen with viruses .
2785859	0	H-2	9,12	YAC-1	114,119	H-2	YAC-1	111364(Tax:10090)	11870(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Enhanced H-2 expression and T-cell-dependent rejection after intracerebral transplantation of the murine lymphoma YAC-1 .
2453562	0	H-2	40,43	class_I	32,39	H-2	class I	111364(Tax:10090)	11980(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Molecular analysis of deficient class_I H-2 antigen expression by mouse lung_carcinoma cells .
3274051	0	H-2	21,24	class_I	13,20	H-2	class I	111364(Tax:10090)	11980(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Influence of class_I H-2 gene expression on local tumor growth .
4077150	0	H-2D	31,35	Mep-1	17,22	H-2D	Mep-1	83772(Tax:10090)	17287(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Proximity of the Mep-1 gene to H-2D on chromosome 17 in mice .
3461476	0	H-2Kb	89,94	class_I	75,82	H-2Kb	class I	14972(Tax:10090)	11980(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Alternative protein products with different carboxyl termini from a single class_I gene , H-2Kb .
6420170	0	H-2_and_Ia	51,61	interferon-gamma	17,33	H-2 and Ia	interferon-gamma	111364(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of cloned interferon-gamma on expression of H-2_and_Ia antigens on cell lines of hemopoietic , lymphoid , epithelial , fibroblastic and neuronal origin .
1329034	0	H-2k	70,74	C4	75,77	H-2k	C4	14972(Tax:10090)	12268(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Insertion of the B2 sequence into intron 13 is the only defect of the H-2k C4 gene which causes low C4 production .
2601687	0	H-7	0,3	ornithine_decarboxylase	65,88	H-7	ornithine decarboxylase	109742(Tax:10090)	18263(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|compound|END_ENTITY	H-7 , a protein kinase C inhibitor , inhibits phorbol_ester-caused ornithine_decarboxylase induction but fails to inhibit phorbol_ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells .
16574350	0	H-FABP	108,114	FATP-4	63,69	H-FABP	FATP-4	2170	10999	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Expression pattern of fatty_acid transport protein-1 -LRB- FATP-1 -RRB- , FATP-4 and heart-fatty_acid binding protein -LRB- H-FABP -RRB- genes in human term placenta .
22290286	0	H-FABP	80,86	LEP	75,78	H-FABP	LEP	399532(Tax:9823)	396832(Tax:9823)	Gene	Gene	genes|amod|START_ENTITY END_ENTITY|appos|genes	Distribution and linkage disequilibrium analysis of polymorphisms of MC4R , LEP , H-FABP genes in the different populations of pigs , associated with economic traits in DIV2 line .
19543317	0	H-RAS	21,26	BMI1	0,4	H-RAS	BMI1	3265	648	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	BMI1 cooperates with H-RAS to induce an aggressive breast_cancer phenotype with brain metastases .
11973642	0	H-REV107-1	36,46	interferon-regulatory_factor-1	62,92	H-REV107-1	interferon-regulatory factor-1	11145	3659	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory_factor-1 and is involved in IFNgamma-induced cell death in human ovarian_carcinoma cells .
19218240	0	H-Ras	18,23	BLNK	0,4	H-Ras	BLNK	3265	29760	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation .
17974970	0	H-Ras	22,27	Bmi-1	0,5	H-Ras	Bmi-1	3265	648	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways .
25458953	0	H-Ras	22,27	CIP2A	0,5	H-Ras	CIP2A	3265	57650	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	CIP2A cooperates with H-Ras to promote epithelial-mesenchymal transition in cervical-cancer progression .
15256455	0	H-Ras	10,15	ERCC1	43,48	H-Ras	ERCC1	3265	2067	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Oncogenic H-Ras up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents .
11709720	0	H-Ras	27,32	Galectin-1	0,10	H-Ras	Galectin-1	3265	3956	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation .
17460778	0	H-Ras	79,84	K-Ras	10,15	H-Ras	K-Ras	3265	3845	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Oncogenic K-Ras signals through epidermal_growth_factor_receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal_carcinoma cells .
24462863	0	H-Ras	53,58	K-Ras	73,78	H-Ras	K-Ras	3265	3845	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function .
27057007	0	H-Ras	78,83	K-Ras	53,58	H-Ras	K-Ras	3265	3845	Gene	Gene	dimers|compound|START_ENTITY differ|nmod|dimers differ|nsubj|dimers dimers|compound|END_ENTITY	Membrane-associated Ras dimers are isoform-specific : K-Ras dimers differ from H-Ras dimers .
16061663	0	H-Ras	10,15	Ku80	43,47	H-Ras	Ku80	15461(Tax:10090)	22596(Tax:10090)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells .
1899909	0	H-Ras	106,111	Rap1A	112,117	H-Ras	Rap1A	15461(Tax:10090)	109905(Tax:10090)	Gene	Gene	START_ENTITY|dep|protein protein|amod|END_ENTITY	The COOH-terminal domain of the Rap1A -LRB- Krev-1 -RRB- protein is isoprenylated and supports transformation by an H-Ras : Rap1A chimeric protein .
21057535	0	H-Ras	55,60	Vimentin	0,8	H-Ras	Vimentin	3265	7431	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast_cancer .
2237442	0	H-Ras	54,59	cytoplasmic_protein	2,21	H-Ras	cytoplasmic protein	3265	8548	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	A cytoplasmic_protein inhibits the GTPase activity of H-Ras in a phospholipid-dependent manner .
11598192	0	H-Ras	13,18	lymphocyte_function_antigen-1	36,65	H-Ras	lymphocyte function antigen-1	3265	3683	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	Dual role of H-Ras in regulation of lymphocyte_function_antigen-1 activity by stromal cell-derived factor-1alpha : implications for leukocyte transmigration .
26138095	0	H-Ras	24,29	p19	12,15	H-Ras	p19	3265	51561	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello_syndrome cell model .
7734422	0	H-Ras	27,32	p21	33,36	H-Ras	p21	15461(Tax:10090)	12575(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation .
16456537	0	H-Ras	95,100	serum_response_factor	60,81	H-Ras	serum response factor	15461(Tax:10090)	20807(Tax:10090)	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Suppression of Egr-1 transcription through targeting of the serum_response_factor by oncogenic H-Ras .
18048363	0	H-Ras	62,67	sprouty_2	14,23	H-Ras	sprouty 2	3265	10253	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	Evidence that sprouty_2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts .
24349383	0	H-ferritin	38,48	Toll-like_receptor_2	103,123	H-ferritin	Toll-like receptor 2	14319(Tax:10090)	24088(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Mycobacterium_avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like_receptor_2 .
25203057	0	H-ficolin	43,52	mannan-binding_lectin	12,33	H-ficolin	mannan-binding lectin	8547	4153	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Circulating mannan-binding_lectin , M - , L - , H-ficolin and collectin-liver-1 levels in patients with acute_liver_failure .
21868531	0	H-ras	0,5	BNIP3	33,38	H-ras	BNIP3	3265	664	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	H-ras up-regulates expression of BNIP3 .
12460470	0	H-ras	65,70	K-ras	58,63	H-ras	K-ras	3265	3845	Gene	Gene	N-ras|dep|START_ENTITY N-ras|dep|END_ENTITY	Molecular analysis of oncogenes , ras family genes -LRB- N-ras , K-ras , H-ras -RRB- , myc family genes -LRB- c-myc , N-myc -RRB- and mdm2 in natural killer cell neoplasms .
9815992	0	H-ras	43,48	K-ras	13,18	H-ras	K-ras	3265	3845	Gene	Gene	mutations|compound|START_ENTITY oncogene|nmod|mutations oncogene|compound|END_ENTITY	Mutations of K-ras oncogene and absence of H-ras mutations in squamous_cell_carcinomas of the lung .
7525612	0	H-ras	118,123	Ornithine_decarboxylase	0,23	H-ras	Ornithine decarboxylase	15461(Tax:10090)	18263(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Ornithine_decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines .
2834383	0	H-ras	0,5	TBE-1	61,66	H-ras	TBE-1	3265	4313	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	H-ras oncogene-transformed human bronchial epithelial cells -LRB- TBE-1 -RRB- secrete a single metalloprotease capable of degrading basement membrane collagen .
8344985	0	H-ras	109,114	Transforming_growth_factor_beta_1	0,33	H-ras	Transforming growth factor beta 1	15461(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed fibrosarcoma cell lines .
12460470	0	H-ras	65,70	c-myc	91,96	H-ras	c-myc	3265	4609	Gene	Gene	N-ras|dep|START_ENTITY genes|appos|N-ras analysis|appos|genes myc|nsubj|analysis myc|dobj|genes genes|appos|END_ENTITY	Molecular analysis of oncogenes , ras family genes -LRB- N-ras , K-ras , H-ras -RRB- , myc family genes -LRB- c-myc , N-myc -RRB- and mdm2 in natural killer cell neoplasms .
12379461	0	H-ras	10,15	cyclin_B1	24,33	H-ras	cyclin B1	3265	891	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Oncogenic H-ras induces cyclin_B1 expression in a p53-independent manner .
12908818	0	H-ras	0,5	epidermal_growth_factor	38,61	H-ras	epidermal growth factor	3265	1950	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	H-ras dependent estrogenic effects of epidermal_growth_factor in the estrogen-independent breast_cancer cell line MDA-MB-231 .
11451381	0	H-ras	108,113	matrix_metalloproteinase-2	76,102	H-ras	matrix metalloproteinase-2	3265	4313	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	Phorbol_ester tumour promoter mediated altered expression and regulation of matrix_metalloproteinase-2 in a H-ras transformed cell line capable of benign tumour formation .
23953123	0	H-ras	45,50	miR-663	29,36	H-ras	miR-663	3265	724033	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The epigenetically-regulated miR-663 targets H-ras in K-562 cells .
11238813	0	H-ras	39,44	p21	35,38	H-ras	p21	15461(Tax:10090)	12575(Tax:10090)	Gene	Gene	processing|appos|START_ENTITY processing|compound|END_ENTITY	Impact of garlic organosulfides on p21 -LRB- H-ras -RRB- processing .
2039838	0	H-ras	4,9	p21	27,30	H-ras	p21	3265	644914	Gene	Gene	product|compound|START_ENTITY product|dep|END_ENTITY	The H-ras oncogene product p21 and prognosis in human breast_cancer .
2199064	0	H-ras	32,37	p21	38,41	H-ras	p21	3265	644914	Gene	Gene	mutants|compound|START_ENTITY mutants|amod|END_ENTITY	Three-dimensional structures of H-ras p21 mutants : molecular basis for their inability to function as signal switch molecules .
2405906	0	H-ras	55,60	p21	61,64	H-ras	p21	3265	644914	Gene	Gene	mutants|compound|START_ENTITY mutants|amod|END_ENTITY	Proton NMR studies of transforming and nontransforming H-ras p21 mutants .
6089191	0	H-ras	38,43	p21	104,107	H-ras	p21	3265	644914	Gene	Gene	genes|compound|START_ENTITY Expression|nmod|genes Expression|nmod|proteins proteins|amod|END_ENTITY	Expression of normal and transforming H-ras genes in Escherichia_coli and purification of their encoded p21 proteins .
8129867	0	H-ras	26,31	p21	45,48	H-ras	p21	3265	644914	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Molecular dynamics of the H-ras gene-encoded p21 protein ; identification of flexible regions and possible effector domains .
17311867	0	H-ras	30,35	p21ras	37,43	H-ras	p21ras	3265	3265	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Morphoproteomic expression of H-ras -LRB- p21ras -RRB- correlates with serum monoclonal immunoglobulin reduction in multiple_myeloma patients following pamidronate treatment .
9241743	0	H1/H2	44,49	fibrinogen	33,43	H1/H2	fibrinogen	3009	2244	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Positive association of the beta fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary_artery_disease and myocardial_infarction .
9241743	0	H1/H2	44,49	fibrinogen	74,84	H1/H2	fibrinogen	3009	2244	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Positive association of the beta fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary_artery_disease and myocardial_infarction .
26692922	0	H19	0,3	CDK6	76,80	H19	CDK6	283120	1021	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	H19 derived microRNA-675 regulates cell proliferation and migration through CDK6 in glioma .
23354591	0	H19	20,23	EZH2	80,84	H19	EZH2	283120	2146	Gene	Gene	increases|nsubj|START_ENTITY increases|advcl|associating associating|nmod|END_ENTITY	Long non-coding RNA H19 increases bladder_cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression .
27040767	0	H19	19,22	EZH2	33,37	H19	EZH2	283120	2146	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal_carcinoma .
26417995	0	H19	20,23	TGF-b1	64,70	H19	TGF-b1	283120	7040	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	Long Non-Coding RNA H19 Promotes Osteoblast Differentiation via TGF-b1 / Smad3/HDAC Signaling 0050athway by Deriving miR-675 .
11896592	0	H19	47,50	Thioredoxin	0,11	H19	Thioredoxin	283120	7295	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Thioredoxin post-transcriptional regulation by H19 provides a new function to mRNA-like non-coding RNA .
27093644	0	H19	19,22	miR-17-5p	43,52	H19	miR-17-5p	283120	406952	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid_cancer .
22527881	0	H19	14,17	microRNA-675	34,46	H19	microRNA-675	283120	100033819	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|amod|END_ENTITY	Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions .
15192231	0	H1b	29,32	MSX1	0,4	H1b	MSX1	56702(Tax:10090)	17701(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis .
15526285	0	H1t	58,61	RFX2	70,74	H1t	RFX2	24438(Tax:10116)	301121(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the testis-specific histone H1t gene by RFX2 may require both proximal promoter X-box elements .
8241275	0	H1t	66,69	testicular_H1_histone	38,59	H1t	testicular H1 histone	3010	107970(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and expression of the mouse testicular_H1_histone gene -LRB- H1t -RRB- .
286291	0	H2A	33,36	A24	20,23	H2A	A24	8337	28924	Gene	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	Semihistone protein A24 replaces H2A as an integral component of the nucleosome histone core .
8018719	0	H2A	17,20	H2B	8,11	H2A	H2B	8337	8349	Gene	Gene	ubiquitination|dep|START_ENTITY ubiquitination|compound|END_ENTITY	Histone H2B -LRB- and H2A -RRB- ubiquitination allows normal histone octamer and core particle reconstitution .
26034280	0	H2A.Z	33,38	Anp32e	18,24	H2A.Z	Anp32e	3015	81611	Gene	Gene	removes|dobj|START_ENTITY removes|nsubj|END_ENTITY	Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair .
26106152	0	H2A.Z	73,78	Anp32e	58,64	H2A.Z	Anp32e	3015	81611	Gene	Gene	removes|dobj|START_ENTITY removes|nsubj|END_ENTITY	Correction for Gursoy-Yuzugullu et al. , Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair .
25839232	0	H2A.Z	31,36	MyoD	109,113	H2A.Z	MyoD	51788(Tax:10090)	17927(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|Expression Expression|compound|END_ENTITY	Expression of Non-acetylatable H2A.Z in Myoblast Cells Blocks Myoblast Differentiation through Disruption of MyoD Expression .
19515975	0	H2A.Z	8,13	estrogen_receptor	31,48	H2A.Z	estrogen receptor	3015	2099	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Histone H2A.Z is essential for estrogen_receptor signaling .
17671089	0	H2A.Z	71,76	p21	0,3	H2A.Z	p21	3015	644914	Gene	Gene	localization|nmod|START_ENTITY regulated|nmod|localization regulated|nsubjpass|transcription transcription|amod|END_ENTITY	p21 transcription is regulated by differential localization of histone H2A.Z .
23146670	0	H2A.Z	44,49	p21	61,64	H2A.Z	p21	3015	644914	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Decrease of p400 ATPase complex and loss of H2A.Z within the p21 promoter occur in senescent IMR-90 human fibroblasts .
23349794	0	H2A.Z	61,66	p21	14,17	H2A.Z	p21	3015	644914	Gene	Gene	acetylation|nmod|START_ENTITY requires|dobj|acetylation requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z .
21937508	0	H2A.Z	39,44	u-PAR	14,19	H2A.Z	u-PAR	3015	5329	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP -1 pathway .
11571274	0	H2AX	27,31	ATM	0,3	H2AX	ATM	3014	472	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	ATM phosphorylates histone H2AX in response to DNA double-strand breaks .
15389585	0	H2AX	8,12	ATM	68,71	H2AX	ATM	3014	472	Gene	Gene	patterns|compound|START_ENTITY patterns|nmod|kinases kinases|nmod|END_ENTITY	Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors .
16184611	0	H2AX	126,130	ATM	14,17	H2AX	ATM	3014	472	Gene	Gene	phosphorylation|compound|START_ENTITY inhibitors|nmod|phosphorylation topoisomerase|ccomp|inhibitors topoisomerase|nsubj|Assessment Assessment|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation , cell cycle phase , and apoptosis .
16426422	0	H2AX	27,31	ATM	0,3	H2AX	ATM	3014	472	Gene	Gene	phosphorylation|nummod|START_ENTITY activation|dobj|phosphorylation activation|nsubj|END_ENTITY	ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis .
20448412	0	H2AX	73,77	ATM	0,3	H2AX	ATM	3014	472	Gene	Gene	phosphorylation|nmod|START_ENTITY involved|nmod|phosphorylation kinase|acl|involved kinase|nsubj|END_ENTITY	ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating .
20888899	0	H2AX	31,35	ATM	91,94	H2AX	ATM	3014	472	Gene	Gene	patterns|compound|START_ENTITY induces|dobj|patterns induces|nmod|kinases kinases|nmod|END_ENTITY	Benzo -LSB- a -RSB- pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM , ATR , and DNA-PK .
26116906	0	H2AX	54,58	ATM	105,108	H2AX	ATM	3014	472	Gene	Gene	phosphorylation|nmod|START_ENTITY induce|dobj|phosphorylation induce|nmod|lymphocytes lymphocytes|acl|mediated mediated|nmod|END_ENTITY	Alpha particles induce pan-nuclear phosphorylation of H2AX in primary human lymphocytes mediated through ATM .
16567133	0	H2AX	30,34	DNA-PK	0,6	H2AX	DNA-PK	3014	5591	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells .
18406329	0	H2AX	42,46	H2AX	79,83	H2AX	H2AX	3014	3014	Gene	Gene	exchange|nmod|START_ENTITY regulated|nsubj|exchange regulated|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16 .
18406329	0	H2AX	79,83	H2AX	42,46	H2AX	H2AX	3014	3014	Gene	Gene	phosphorylation|nmod|START_ENTITY regulated|nmod|phosphorylation regulated|nsubj|exchange exchange|nmod|END_ENTITY	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16 .
16377563	0	H2AX	43,47	MDC1	0,4	H2AX	MDC1	3014	9656	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks .
18406329	0	H2AX	42,46	Spt16	108,113	H2AX	Spt16	3014	11198	Gene	Gene	exchange|nmod|START_ENTITY regulated|nsubj|exchange regulated|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16 .
18406329	0	H2AX	79,83	Spt16	108,113	H2AX	Spt16	3014	11198	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16 .
15635261	0	H2AX	78,82	p53	16,19	H2AX	p53	3014	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	No induction of p53 phosphorylation and few focus formation of phosphorylated H2AX suggest efficient repair of DNA damage during chronic low-dose-rate irradiation in human cells .
21858116	0	H2AX	62,66	p53	30,33	H2AX	p53	15270(Tax:10090)	22060(Tax:10090)	Gene	Gene	down-regulation|nmod|START_ENTITY mediated|dobj|down-regulation mediated|nsubj|Onset Onset|nmod|END_ENTITY	Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells .
8018719	0	H2B	8,11	H2A	17,20	H2B	H2A	8349	8337	Gene	Gene	ubiquitination|compound|START_ENTITY ubiquitination|dep|END_ENTITY	Histone H2B -LRB- and H2A -RRB- ubiquitination allows normal histone octamer and core particle reconstitution .
18682386	0	H2B	12,15	Histone_2B	0,10	H2B	Histone 2B	8349	8349	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Histone_2B -LRB- H2B -RRB- expression is confined to a proper NAD + / NADH redox status .
7642556	0	H2O2_and_tumor_necrosis_factor-alpha	0,36	intercellular_adhesion_molecule_1	46,79	H2O2 and tumor necrosis factor-alpha	intercellular adhesion molecule 1	7124	3383	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|gene gene|amod|END_ENTITY	H2O2_and_tumor_necrosis_factor-alpha activate intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter .
19673568	0	H2_and_D2	10,19	CO2	64,67	H2 and D2	CO2	6019;28503	717	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Ultrafast H2_and_D2 rotational Raman responses in near critical CO2 : an experimental and theoretical study of anisotropic solvation dynamics .
16969075	0	H32	0,3	Cdc25	99,104	H32	Cdc25	126961	995	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|inhibiting inhibiting|dobj|END_ENTITY	H32 , a non-quinone_sulfone analog of vitamin_K3 , inhibits human hepatoma cell growth by inhibiting Cdc25 and activating ERK .
19379485	0	H6_Homeobox_1	6,19	Hmx1	21,25	H6 Homeobox 1	Hmx1	15371(Tax:10090)	15371(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Mouse H6_Homeobox_1 -LRB- Hmx1 -RRB- mutations cause cranial_abnormalities and reduced body mass .
9443814	0	HABP2	85,90	PHBP	73,77	HABP2	PHBP	3026	3026	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the plasma_hyaluronan-binding_protein -LRB- PHBP -RRB- gene -LRB- HABP2 -RRB- .
9443814	0	HABP2	85,90	plasma_hyaluronan-binding_protein	38,71	HABP2	plasma hyaluronan-binding protein	3026	3026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the plasma_hyaluronan-binding_protein -LRB- PHBP -RRB- gene -LRB- HABP2 -RRB- .
22375075	0	HADHB	61,66	Estrogen_receptor_alpha	0,23	HADHB	Estrogen receptor alpha	3032	2099	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Estrogen_receptor_alpha interacts with mitochondrial protein HADHB and affects beta-oxidation activity .
15525647	0	HAF2	12,16	TAF1	76,80	HAF2	TAF1	821437(Tax:3702)	821437(Tax:3702)	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Arabidopsis HAF2 gene encoding TATA-binding protein -LRB- TBP -RRB- - associated factor TAF1 , is required to integrate light signals to regulate gene expression and growth .
15117945	0	HAGH	44,48	hydroxyacylglutathione_hydrolase	10,42	HAGH	hydroxyacylglutathione hydrolase	3029	3029	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Human hydroxyacylglutathione_hydrolase -LRB- HAGH -RRB- gene encodes both cytosolic and mitochondrial forms of glyoxalase_II .
10982193	0	HAH1	46,50	ATX1	30,34	HAH1	ATX1	475	475	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Physical mapping of the human ATX1 homologue -LRB- HAH1 -RRB- to the critical region of the 5q - syndrome within 5q32 , and immediately adjacent to the SPARC gene .
23393351	0	HAI-1	67,72	Hepatocyte_growth_factor_activator_inhibitor_type-1	14,65	HAI-1	Hepatocyte growth factor activator inhibitor type-1	6692	6692	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Hepatocyte_growth_factor_activator_inhibitor_type-1 -LRB- HAI-1 -RRB- in prostate_cancer .
19578736	0	HAI-1	60,65	hepatocyte_growth_factor_activator_inhibitor-1	12,58	HAI-1	hepatocyte growth factor activator inhibitor-1	6692	6692	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of hepatocyte_growth_factor_activator_inhibitor-1 -LRB- HAI-1 -RRB- as a prognostic indicator in cervical_cancer .
10219059	0	HAI-1	69,74	hepatocyte_growth_factor_activator_inhibitor_type_1	16,67	HAI-1	hepatocyte growth factor activator inhibitor type 1	6692	6692	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of hepatocyte_growth_factor_activator_inhibitor_type_1 -LRB- HAI-1 -RRB- in human tissues .
8530107	0	HAL	79,82	histidase	63,72	HAL	histidase	3034	3034	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and structural characterization of the human histidase gene -LRB- HAL -RRB- .
23273925	0	HAM1	42,46	FLC	87,90	HAM1	FLC	836582(Tax:3702)	830878(Tax:3702)	Gene	Gene	START_ENTITY|nmod|modification modification|nmod|END_ENTITY	Requirement of histone acetyltransferases HAM1 and HAM2 for epigenetic modification of FLC in regulating flowering in Arabidopsis .
16887337	0	HAN11	0,5	mDia1	12,17	HAN11	mDia1	71833(Tax:10090)	13367(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	HAN11 binds mDia1 and controls GLI1 transcriptional activity .
10974549	0	HAP-1	37,42	huntingtin-associated_protein	6,35	HAP-1	huntingtin-associated protein	9001	9001	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human huntingtin-associated_protein -LRB- HAP-1 -RRB- gene : genomic organisation and an intragenic polymorphism .
2844525	0	HAP1	109,113	CYP1	115,119	HAP1	CYP1	850958(Tax:4932)	850958(Tax:4932)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins : a binding site for the HAP1 -LRB- CYP1 -RRB- protein in the UAS region of the yeast catalase_T gene -LRB- CTT1 -RRB- .
7957173	0	HAP1	66,70	CYP1	61,65	HAP1	CYP1	850958(Tax:4932)	850958(Tax:4932)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	The DNA-binding domain of the yeast Saccharomyces_cerevisiae CYP1 -LRB- HAP1 -RRB- transcription factor possesses two zinc ions which are complexed in a zinc cluster .
8458333	0	HAP1	45,49	CYP1	40,44	HAP1	HAP1	850958(Tax:4932)	850958(Tax:4932)	Gene	Gene	activator|appos|START_ENTITY activator|compound|END_ENTITY	Evidence for an interaction between the CYP1 -LRB- HAP1 -RRB- activator and a cellular factor during heme-dependent transcriptional regulation in the yeast Saccharomyces_cerevisiae .
9751154	0	HAP1	49,53	Huntingtin-associated_protein	18,47	HAP1	Huntingtin-associated protein	29430(Tax:10116)	29430(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The expression of Huntingtin-associated_protein -LRB- HAP1 -RRB- mRNA in developing , adult and ageing rat CNS : implications for Huntington 's _ disease neuropathology .
20953637	0	HAPLN1	82,88	hyaluronan_and_proteoglycan_link_protein_1	38,80	HAPLN1	hyaluronan and proteoglycan link protein 1	1404	1404	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single-nucleotide polymorphism in the hyaluronan_and_proteoglycan_link_protein_1 -LRB- HAPLN1 -RRB- gene is associated with spinal osteophyte formation and disc_degeneration in Japanese women .
9624189	0	HARL1	129,134	phospholipase_D	64,79	HARL1	phospholipase D	400	2822	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Phospholipid - and GTP-dependent activation of cholera_toxin and phospholipase_D by human ADP-ribosylation factor-like protein 1 -LRB- HARL1 -RRB- .
22930593	0	HARS	66,70	histidyl-tRNA_synthetase	40,64	HARS	histidyl-tRNA synthetase	3035	3035	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A loss-of-function variant in the human histidyl-tRNA_synthetase -LRB- HARS -RRB- gene is neurotoxic in vivo .
18815290	0	HAS1	64,68	hyaluronan_synthase_1	41,62	HAS1	hyaluronan synthase 1	3036	3036	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inherited and acquired variations in the hyaluronan_synthase_1 -LRB- HAS1 -RRB- gene may contribute to disease progression in multiple_myeloma and Waldenstrom_macroglobulinemia .
20960509	0	HAS1	47,51	hyaluronic_acid_family_members	15,45	HAS1	hyaluronic acid family members	3036	3036	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association of hyaluronic_acid_family_members -LRB- HAS1 , HAS2 , and HYAL-1 -RRB- with bladder_cancer diagnosis and prognosis .
21357421	0	HAS2	33,37	hyaluronan_synthase_2	10,31	HAS2	hyaluronan synthase 2	3037	3037	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human hyaluronan_synthase_2 -LRB- HAS2 -RRB- gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell .
24847057	0	HAS2	183,187	hyaluronan_synthase_2	160,181	HAS2	hyaluronan synthase 2	3037	3037	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Extracellular UDP-glucose activates P2Y14_Receptor and Induces Signal_Transducer_and_Activator_of_Transcription_3 -LRB- STAT3 -RRB- Tyr705 phosphorylation and binding to hyaluronan_synthase_2 -LRB- HAS2 -RRB- promoter , stimulating hyaluronan synthesis of keratinocytes .
14752026	0	HAS2	41,45	hyaluronic_acid_synthase_2	13,39	HAS2	hyaluronic acid synthase 2	3037	3037	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of hyaluronic_acid_synthase_2 -LRB- HAS2 -RRB- in human vascular smooth muscle cells by vasodilatory prostaglandins .
17165436	0	HASH2	13,18	ASCL2	20,25	HASH2	ASCL2	430	430	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of HASH2 -LRB- ASCL2 -RRB- gene expression in gestational_trophoblastic_disease .
25925205	0	HAUSP	0,5	c-MYC	16,21	HAUSP	c-MYC	7874	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP .
17241641	0	HAX-1	29,34	Phospholamban	0,13	HAX-1	Phospholamban	10456	5350	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Phospholamban interacts with HAX-1 , a mitochondrial protein with anti-apoptotic function .
18971376	0	HAX-1	27,32	SERCA2	48,54	HAX-1	SERCA2	10456	488	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival .
26553996	0	HAX-1	0,5	cyclophilin-D	16,29	HAX-1	cyclophilin-D	10456	10105	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart .
20406461	0	HAX1	22,26	Pelota	0,6	HAX1	Pelota	10456	53918	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pelota interacts with HAX1 , EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton .
21567072	0	HAX1	21,25	hSav1	0,5	HAX1	hSav1	10456	60485	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	hSav1 interacts with HAX1 and attenuates its anti-apoptotic effects in MCF-7 breast_cancer cells .
21471992	0	HB-EGF	0,6	COL7A1	15,21	HB-EGF	COL7A1	1839	1294	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	HB-EGF induces COL7A1 expression in keratinocytes and fibroblasts : possible mechanism underlying allogeneic fibroblast therapy in recessive_dystrophic_epidermolysis_Bullosa .
20351696	0	HB-EGF	19,25	Cdx2	35,39	HB-EGF	Cdx2	1839	1045	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Fibroblast-derived HB-EGF promotes Cdx2 expression in esophageal squamous cells .
20208558	0	HB-EGF	53,59	EGFR	14,18	HB-EGF	EGFR	1839	1956	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of EGFR by proteasome inhibition requires HB-EGF in pancreatic_cancer cells .
25779761	0	HB-EGF	54,60	Heparin-Binding_EGF-Like_Growth_Factor	14,52	HB-EGF	Heparin-Binding EGF-Like Growth Factor	522921(Tax:9913)	522921(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Heparin-Binding_EGF-Like_Growth_Factor -LRB- HB-EGF -RRB- in Bovine Endometrium : Effects of HB-EGF and Interferon - on Prostaglandin Production .
25939532	0	HB-EGF	27,33	Interleukin-22	0,14	HB-EGF	Interleukin-22	1839	50616	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-22 upregulates HB-EGF expression in HaCaT cells via JAK2/STAT3 and ERK1/2 signalling .
19682489	0	HB-EGF	97,103	MMP-7	91,96	HB-EGF	MMP-7	1839	4316	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Cellular senescence of human mammary epithelial cells -LRB- HMEC -RRB- is associated with an altered MMP-7 / HB-EGF signaling and increased formation of elastin-like structures .
17822789	0	HB-EGF	0,6	STAT3	23,28	HB-EGF	STAT3	1839	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell .
11889210	0	HB-EGF	43,49	decay-accelerating_factor	92,117	HB-EGF	decay-accelerating factor	1839	1604	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating_factor .
18925469	0	HB-EGF	0,6	eNOS	18,22	HB-EGF	eNOS	1839	4846	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	HB-EGF stimulates eNOS expression and nitric_oxide production and promotes eNOS dependent angiogenesis .
12746188	0	HB-EGF	67,73	heparin-binding_EGF-like_growth_factor	27,65	HB-EGF	heparin-binding EGF-like growth factor	25433(Tax:10116)	25433(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of endogenous heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- expression after intestinal_ischemia / reperfusion injury .
14756521	0	HB-EGF	67,73	heparin-binding_EGF-like_growth_factor	27,65	HB-EGF	heparin-binding EGF-like growth factor	1839	1839	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Differential expression of heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- mRNA in normal human keratinocytes induced by a variety of natural and synthetic retinoids .
16364500	0	HB-EGF	84,90	heparin-binding_EGF-like_growth_factor	44,82	HB-EGF	heparin-binding EGF-like growth factor	25433(Tax:10116)	25433(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Tissue distribution and plasma clearance of heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- in adult and newborn rats .
12028437	0	HB-EGF	83,89	heparin-binding_epidermal_growth_factor-like_growth_factor	23,81	HB-EGF	heparin-binding epidermal growth factor-like growth factor	25433(Tax:10116)	25433(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of membrane-bound heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- in renal epithelial cell branching .
22342671	0	HB-EGF	107,113	heparin-binding_epidermal_growth_factor-like_growth_factor	47,105	HB-EGF	heparin-binding epidermal growth factor-like growth factor	1839	1839	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The cell-penetrating peptide domain from human heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- has anti-inflammatory activity in vitro and in vivo .
8592081	0	HB-EGF	74,80	heparin-binding_epidermal_growth_factor-like_growth_factor	14,72	HB-EGF	heparin-binding epidermal growth factor-like growth factor	1839	1839	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- at sites of thermal_injury in pediatric patients .
10210777	0	HB-EGF	202,208	heparin_binding_epidermal_growth_factor-like_growth_factor	142,200	HB-EGF	heparin binding epidermal growth factor-like growth factor	1839	1839	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Adhesion of human monocytic THP-1 cells to endothelial_cell_adhesion_molecules or extracellular matrix proteins via beta1_integrins regulates heparin_binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- expression .
7955315	0	HB-GAM	14,20	HB-GAM	164,170	HB-GAM	HB-GAM	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY induced|nsubj|Expression induced|nmod|END_ENTITY	Expression of HB-GAM -LRB- heparin-binding_growth-associated_molecules -RRB- in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM .
7955315	0	HB-GAM	164,170	HB-GAM	14,20	HB-GAM	HB-GAM	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of HB-GAM -LRB- heparin-binding_growth-associated_molecules -RRB- in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM .
7722643	0	HB-GAM	56,62	heparin-binding_growth-associated_molecule	12,54	HB-GAM	heparin-binding growth-associated molecule	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- in the postsynaptic induction in cultured muscle cells .
8653419	0	HB-GAM	83,89	heparin-binding_growth-associated_molecule	39,81	HB-GAM	heparin-binding growth-associated molecule	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of the heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- in the developing and adult rat cerebellar cortex .
8812110	0	HB-GAM	8,14	heparin-binding_growth-associated_molecule	16,58	HB-GAM	heparin-binding growth-associated molecule	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of HB-GAM -LRB- heparin-binding_growth-associated_molecule -RRB- in proliferation arrest in cells of the developing rat limb and its expression in the differentiating neuromuscular system .
9389569	0	HB-GAM	99,105	heparin-binding_growth-associated_molecule	55,97	HB-GAM	heparin-binding growth-associated molecule	5764	5764	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression and biological activity of the heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- in lung_cancer cell lines .
9753126	0	HB-GAM	54,60	heparin-binding_growth-associated_molecule	10,52	HB-GAM	heparin-binding growth-associated molecule	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- on synaptic transmission and early LTP in rat hippocampal slices .
1407714	0	HB-GAM	36,42	pleiotrophin	22,34	HB-GAM	pleiotrophin	5764	5764	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	The new growth factor pleiotrophin -LRB- HB-GAM -RRB- mRNA is selectively present in the meningothelial cells of human meningiomas .
26950997	0	HBD-2	53,58	TGF-b	67,72	HBD-2	TGF-b	1673	7040	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	-LSB- STUDY OF THE ROLE OF INNATE IMMUNITY FACTORS -LRB- TLR2 , HBD-2 , TNF-a , TGF-b -RRB- IN PERIODONTITIS PATHOGENESIS -RSB- .
19519528	0	HBD2	47,51	beta-defensin_2	30,45	HBD2	beta-defensin 2	1673	1673	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Efficient production of human beta-defensin_2 -LRB- HBD2 -RRB- in Escherichia_coli .
25451232	0	HBEGF-EGFR	58,68	miR-96	0,6	HBEGF-EGFR	miR-96	15200;13649	723886(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	miR-96 promotes osteogenic differentiation by suppressing HBEGF-EGFR signaling in osteoblastic cells .
1477961	0	HBNF	18,22	heparin-binding_neurite-promoting_factor	24,64	HBNF	heparin-binding neurite-promoting factor	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the HBNF -LRB- heparin-binding_neurite-promoting_factor -RRB- gene in the brain of fetal , neonatal and adult rat : an in situ hybridization study .
15963510	0	HBO1	47,51	Cyclin-dependent_kinase_11	0,26	HBO1	Cyclin-dependent kinase 11	11143	23097	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cyclin-dependent_kinase_11 -LRB- p58 -RRB- interacts with HBO1 and enhances its histone acetyltransferase activity .
18029353	0	HBO1	53,57	FAD24	0,5	HBO1	FAD24	11143	64318	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	FAD24 acts in concert with histone acetyltransferase HBO1 to promote adipogenesis by controlling DNA replication .
18684714	0	HBO1	54,58	Jade-1	8,14	HBO1	Jade-1	11143	79960	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Jade-1 in the histone acetyltransferase -LRB- HAT -RRB- HBO1 complex .
11278932	0	HBO1	78,82	MCM2	20,24	HBO1	MCM2	11143	4171	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1 .
16645042	0	HBO1	77,81	histone_acetyltransferase_binding_to_ORC-1	33,75	HBO1	histone acetyltransferase binding to ORC-1	11143	11143	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Ligand-controlled interaction of histone_acetyltransferase_binding_to_ORC-1 -LRB- HBO1 -RRB- with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription .
20581871	0	HBP1	23,27	P16	36,39	HBP1	P16	26959	1029	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Transcriptional factor HBP1 targets P16 -LRB- INK4A -RRB- , upregulating its expression and consequently is involved in Ras-induced premature senescence .
20505989	0	HBP1	90,94	miR-17-5p	0,9	HBP1	miR-17-5p	26959	406952	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	miR-17-5p promotes human breast_cancer cell migration and invasion through suppression of HBP1 .
21131837	0	HBXAP	7,12	Rsf-1	0,5	HBXAP	Rsf-1	51773	51773	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Rsf-1 -LRB- HBXAP -RRB- expression is associated with advanced stage and lymph node metastasis in ovarian_clear_cell_carcinoma .
22293503	0	HBXIP	0,5	CD46	18,22	HBXIP	CD46	10542	4179	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	HBXIP upregulates CD46 , CD55 and CD59 through ERK1/2/NF-kB signaling to protect breast_cancer cells from complement attack .
24882622	0	HBXIP	16,21	E2F1	59,63	HBXIP	E2F1	10542	1869	Gene	Gene	START_ENTITY|advcl|modulating modulating|dobj|END_ENTITY	The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells .
26828265	0	HBXIP	16,21	Sp1	82,85	HBXIP	Sp1	10542	6667	Gene	Gene	START_ENTITY|advcl|activating activating|dobj|END_ENTITY	The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast_cancer cells .
17303008	0	HBXIP	50,55	hepatitis_B_X-interacting_protein	15,48	HBXIP	hepatitis B X-interacting protein	10542	10542	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of hepatitis_B_X-interacting_protein -LRB- HBXIP -RRB- in proliferation regulation of cells .
18158869	0	HBXIP	35,40	telomerase_reverse_transcriptase	67,99	HBXIP	telomerase reverse transcriptase	10542	7015	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Promotion of cell proliferation by HBXIP via upregulation of human telomerase_reverse_transcriptase in human mesenchymal stem cells .
15592508	0	HBZ	7,10	AP-1	22,26	HBZ	AP-1	3050	3725	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein .
15044019	0	HBZ	0,3	JunD	19,23	HBZ	JunD	3050	3727	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HBZ interacts with JunD and stimulates its transcriptional activity .
23038672	0	HC11	134,138	EGF-factor_VIII	47,62	HC11	EGF-factor VIII	15142(Tax:10090)	17304(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Post-weaning increases in the milk-fat globule EGF-factor_VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells .
9179297	0	HC11	119,123	LH_receptor	104,115	HC11	LH receptor	6347	3973	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Recombinant expression and secretion of a natural splicing variant containing the ectodomain of porcine LH_receptor in HC11 mammary epithelial cells .
14674694	0	HC8	51,54	aurora-B	6,14	HC8	aurora-B	5684	9212	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner .
22743741	0	HCA	8,11	GPR109A	16,23	HCA	GPR109A	266790	338442	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of HCA -LRB- GPR109A -RRB- in nicotinic_acid and fumaric_acid_ester-induced effects on the skin .
12672042	0	HCAP	53,57	human_cachexia-associated_protein	18,51	HCAP	human cachexia-associated protein	117159	117159	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the human_cachexia-associated_protein -LRB- HCAP -RRB- in prostate_cancer and in a prostate_cancer animal model of cachexia .
10072876	0	HCC	30,33	ICAM-1	15,21	HCC	ICAM-1	619501	3383	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	-LSB- Expression of ICAM-1 mRNA in HCC using in situ hybridization technique -RSB- .
19815555	0	HCF-1	76,81	BAP1	28,32	HCF-1	BAP1	3054	8314	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1 .
12149646	0	HCF-1	33,38	PDCD2	0,5	HCF-1	PDCD2	3054	5134	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PDCD2 is a negative regulator of HCF-1 -LRB- C1 -RRB- .
20200153	0	HCF-1	63,68	THAP1	29,34	HCF-1	THAP1	3054	55145	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc_transferase : a link between DYT6 and DYT3_dystonias .
27009953	0	HCF1	0,4	EBNA1	29,34	HCF1	EBNA1	3054	17494214	Gene	Gene	Cooperate|nsubj|START_ENTITY Cooperate|nmod|END_ENTITY	HCF1 and OCT2 Cooperate with EBNA1 to Enhance OriP-Dependent Transcription and Episome Maintenance of Latent Epstein-Barr_Virus .
17971335	0	HCF208	0,6	CCB2	35,39	HCF208	CCB2	835287(Tax:3702)	5718457(Tax:3055)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	HCF208 , a homolog of Chlamydomonas CCB2 , is required for accumulation of native cytochrome_b6 in Arabidopsis_thaliana .
8661027	0	HCFC1	49,54	host_cell_factor	29,45	HCFC1	host cell factor	3054	3054	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The complete sequence of the host_cell_factor 1 -LRB- HCFC1 -RRB- gene and its promoter : a role for YY1 transcription factor in the regulation of its expression .
8833156	0	HCFC1	84,89	host_cell_factor	61,77	HCFC1	host cell factor	3054	3054	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The chromosome localization and the HCF repeats of the human host_cell_factor gene -LRB- HCFC1 -RRB- are conserved in the mouse homologue .
18591213	0	HCG	0,3	hypoxia_inducible_factor-1_alpha	17,49	HCG	hypoxia inducible factor-1 alpha	1081	3091	Gene	Gene	up-regulates|compound|START_ENTITY up-regulates|amod|END_ENTITY	HCG up-regulates hypoxia_inducible_factor-1_alpha in luteinized granulosa cells : implications for the hormonal regulation of vascular_endothelial_growth_factor_A in the human corpus luteum .
26830115	0	HCG22	45,50	HLA_complex_group_22	18,38	HCG22	HLA complex group 22	285834	285834	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants near the HLA_complex_group_22 gene -LRB- HCG22 -RRB- confer increased susceptibility to late-onset asthma in Japanese populations .
11150588	0	HCII	23,27	Thrombin	0,8	HCII	Thrombin	3053	2147	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin-HCII complex .
21993313	0	HCK	45,48	hematopoietic_cell_kinase	18,43	HCK	hematopoietic cell kinase	3055	3055	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the hematopoietic_cell_kinase -LRB- HCK -RRB- by PML/RARa and PU .1 in acute_promyelocytic_leukemia .
9822652	0	HCK	111,114	hematopoietic_cell_kinase	84,109	HCK	hematopoietic cell kinase	3055	3055	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic_cell_kinase -LRB- HCK -RRB- gene through binding to two adjacent GC boxes within the HCK promoter-proximal region .
10400919	0	HCN	75,78	hyperpolarization-activated_cation_channel	31,73	HCN	hyperpolarization-activated cation channel	100009452(Tax:9986)	100009452(Tax:9986)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Distribution and prevalence of hyperpolarization-activated_cation_channel -LRB- HCN -RRB- mRNA expression in cardiac tissues .
19073170	0	HCN1	21,25	CA1	51,54	HCN1	CA1	348980	759	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	WITHDRAWN : Decreased HCN1 mRNA in hippocampal area CA1 and neocortex after chronic cerebral_hypoperfusion .
23907424	0	HCN2	55,59	Hyperpolarization-activated_cyclic_nucleotide-gated_2	0,53	HCN2	Hyperpolarization-activated cyclic nucleotide-gated 2	610	610	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Hyperpolarization-activated_cyclic_nucleotide-gated_2 -LRB- HCN2 -RRB- polymorphism is associated with chronic inflammatory_periodontitis .
19820968	0	HCN4	55,59	Hyperpolarization-activated_cyclic-nucleotide_gated_4	0,53	HCN4	Hyperpolarization-activated cyclic-nucleotide gated 4	59266(Tax:10116)	59266(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Hyperpolarization-activated_cyclic-nucleotide_gated_4 -LRB- HCN4 -RRB- protein is expressed in a subset of rat dorsal root and trigeminal ganglion neurons .
10210891	0	HCNP	65,69	hippocampal_cholinergic_neurostimulating_peptide	15,63	HCNP	hippocampal cholinergic neurostimulating peptide	5037	5037	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	High levels of hippocampal_cholinergic_neurostimulating_peptide -LRB- HCNP -RRB- in the CSF of some patients with Alzheimer 's _ disease .
8720492	0	HCNP	66,70	hippocampal_cholinergic_neurostimulating_peptide	16,64	HCNP	hippocampal cholinergic neurostimulating peptide	29542(Tax:10116)	29542(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of hippocampal_cholinergic_neurostimulating_peptide -LRB- HCNP -RRB- immunoreactivity in the central nervous system of the rat .
17221218	0	HCR	12,15	CCHCR1	4,10	HCR	CCHCR1	54535	54535	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The CCHCR1 -LRB- HCR -RRB- gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes .
9630604	0	HCS	46,49	holocarboxylase_synthetase	18,44	HCS	holocarboxylase synthetase	3141	3141	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Identification of holocarboxylase_synthetase -LRB- HCS -RRB- proteins in human placenta .
16720300	0	HD-PTP	25,31	FGF-2	48,53	HD-PTP	FGF-2	25930	2247	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation .
22368268	0	HD2C	0,4	HDA6	20,24	HD2C	HDA6	831733(Tax:3702)	836431(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HD2C interacts with HDA6 and is involved in ABA and salt stress response in Arabidopsis .
23271976	0	HDA6	20,24	AS1	57,60	HDA6	AS1	836431(Tax:3702)	818340(Tax:3702)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Histone deacetylase HDA6 is functionally associated with AS1 in repression of KNOX genes in arabidopsis .
22368268	0	HDA6	20,24	HD2C	0,4	HDA6	HD2C	836431(Tax:3702)	831733(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HD2C interacts with HDA6 and is involved in ABA and salt stress response in Arabidopsis .
25864671	0	HDAC	48,52	Histone_Deacetylase	27,46	HDAC	Histone Deacetylase	9734	9734	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Chemical Tools for Probing Histone_Deacetylase -LRB- HDAC -RRB- Activity .
26418117	0	HDAC	38,42	Histone_Deacetylase	17,36	HDAC	Histone Deacetylase	9734	9734	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Light-Controlled Histone_Deacetylase -LRB- HDAC -RRB- Inhibitors : Towards Photopharmacological Chemotherapy .
19359173	0	HDAC	119,123	histone_deacetylase	98,117	HDAC	histone deacetylase	9734	9734	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Exploring bis - -LRB- indolyl -RRB- methane moiety as an alternative and innovative CAP group in the design of histone_deacetylase -LRB- HDAC -RRB- inhibitors .
22005560	0	HDAC	39,43	histone_deacetylase	18,37	HDAC	histone deacetylase	9734	9734	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	-LSB- The effects of a histone_deacetylase -LRB- HDAC -RRB- inhibitor on endotoxin-induced endothelial cell injury -RSB- .
26185616	0	HDAC	97,101	histone_deacetylase	76,95	HDAC	histone deacetylase	9734	9734	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Cellular prostatic acid phosphatase -LRB- cPAcP -RRB- serves as a useful biomarker of histone_deacetylase -LRB- HDAC -RRB- inhibitors in prostate_cancer cell growth suppression .
17982666	0	HDAC	40,44	p53	25,28	HDAC	p53	9734	7157	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon_cancer cells in vitro and in vivo .
19252524	0	HDAC-1	17,23	miR-449a	0,8	HDAC-1	miR-449a	3065	554213	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-449a targets HDAC-1 and induces growth_arrest in prostate_cancer .
18622015	0	HDAC1	0,5	C/EBPalpha	22,32	HDAC1	C/EBPalpha	433759(Tax:10090)	12606(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	HDAC1 cooperates with C/EBPalpha in the inhibition of liver proliferation in old mice .
12574125	0	HDAC1	57,62	C/EBPbeta	84,93	HDAC1	C/EBPbeta	433759(Tax:10090)	12608(Tax:10090)	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta .
21184735	0	HDAC1	15,20	E-cadherin	24,34	HDAC1	E-cadherin	3065	999	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Involvement of HDAC1 in E-cadherin expression in prostate_cancer cells ; its implication for cell motility and invasion .
21974802	0	HDAC1	15,20	Foxp3	0,5	HDAC1	Foxp3	3065	50943	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Foxp3 inhibits HDAC1 activity to modulate gene expression in human T cells .
26812044	0	HDAC1	49,54	GAD67	73,78	HDAC1	GAD67	3065	2571	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nummod|END_ENTITY	Toward dissecting the etiology of schizophrenia : HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model .
15361834	0	HDAC1	34,39	ICBP90	0,6	HDAC1	ICBP90	3065	29128	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	ICBP90 , an E2F-1 target , recruits HDAC1 and binds to methyl-CpG through its SRA domain .
26098774	0	HDAC1	14,19	MORC2	21,26	HDAC1	MORC2	3065	22880	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	By recruiting HDAC1 , MORC2 suppresses p21 Waf1/Cip1 in gastric_cancer .
25173798	0	HDAC1	50,55	MiR-34a	0,7	HDAC1	MiR-34a	3065	407040	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast_cancer .
18588874	0	HDAC1	89,94	SP-1	84,88	HDAC1	SP-1	3065	6667	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|END_ENTITY	Induction of truncated form of tenascin-X -LRB- XB-S -RRB- through dissociation of HDAC1 from SP-1 / HDAC1 complex in response to hypoxic conditions .
22731250	0	HDAC1	42,47	SPRR2A	0,6	HDAC1	SPRR2A	3065	6700	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity .
22147512	0	HDAC1	36,41	ZEB1	85,89	HDAC1	ZEB1	3065	6935	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic_cancer .
18611949	0	HDAC1	37,42	histone_deacetylase1	15,35	HDAC1	histone deacetylase1	3065	3065	Gene	Gene	Requirement|appos|START_ENTITY Requirement|nmod|END_ENTITY	Requirement of histone_deacetylase1 -LRB- HDAC1 -RRB- in signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- nucleocytoplasmic distribution .
23657855	0	HDAC11	24,30	PAI-1	75,80	HDAC11	PAI-1	232232(Tax:10090)	18787(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	Gender-specific role of HDAC11 in kidney_ischemia - and reperfusion-induced PAI-1 expression and injury .
25486475	0	HDAC2	81,86	BRG1	0,4	HDAC2	BRG1	3066	6597	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRG1 , the ATPase subunit of SWI/SNF chromatin remodeling complex , interacts with HDAC2 to modulate telomerase expression in human cancer cells .
20534591	0	HDAC2	80,85	CAGE	22,26	HDAC2	CAGE	3066	168400	Gene	Gene	exerts|nmod|START_ENTITY exerts|nsubj|END_ENTITY	Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs .
10888872	0	HDAC2	12,17	DNMT1	0,5	HDAC2	DNMT1	3066	1786	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	DNMT1 binds HDAC2 and a new co-repressor , DMAP1 , to form a complex at replication foci .
25642316	0	HDAC2	59,64	Histone_Deacetylase_2	36,57	HDAC2	Histone Deacetylase 2	15182(Tax:10090)	15182(Tax:10090)	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|nmod|END_ENTITY	Kinetically Selective Inhibitors of Histone_Deacetylase_2 -LRB- HDAC2 -RRB- as Cognition Enhancers .
24788349	0	HDAC2	53,58	PTEN	18,22	HDAC2	PTEN	3066	5728	Gene	Gene	restores|nmod|START_ENTITY restores|dobj|expression expression|compound|END_ENTITY	Melittin restores PTEN expression by down-regulating HDAC2 in human hepatocelluar_carcinoma HepG2 cells .
23639777	0	HDAC3	0,5	C/EBPa	32,38	HDAC3	C/EBPa	84578(Tax:10116)	24252(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HDAC3 interacts with sumoylated C/EBPa to negatively regulate the LXRa expression in rat hepatocytes .
26704017	0	HDAC3	60,65	C/EBPa	0,6	HDAC3	C/EBPa	8841	1050	Gene	Gene	recruiting|dobj|START_ENTITY expression|acl|recruiting regulates|dobj|expression regulates|nsubj|END_ENTITY	C/EBPa negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular_carcinoma cells .
23905631	0	HDAC3	22,27	Cpt1a	43,48	HDAC3	Cpt1a	15183(Tax:10090)	12894(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Binge ethanol-induced HDAC3 down-regulates Cpt1a expression leading to hepatic_steatosis and injury .
21030595	0	HDAC3	0,5	DBC1	53,57	HDAC3	DBC1	15183(Tax:10090)	56710(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	HDAC3 is negatively regulated by the nuclear protein DBC1 .
25305081	0	HDAC3	27,32	PINK1	0,5	HDAC3	PINK1	8841	65018	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death .
11470869	0	HDAC3	24,29	RbAp48	38,44	HDAC3	RbAp48	8841	5928	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein .
10809664	0	HDAC3	43,48	SMRT	7,11	HDAC3	SMRT	8841	9612	Gene	Gene	containing|dobj|START_ENTITY END_ENTITY|xcomp|containing	A core SMRT corepressor complex containing HDAC3 and TBL1 , a WD40-repeat protein linked to deafness .
19121623	0	HDAC3	0,5	STAT3	36,41	HDAC3	STAT3	8841	6774	Gene	Gene	influences|nsubj|START_ENTITY influences|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A .
21346816	0	HDAC3	8,13	p53	17,20	HDAC3	p53	8841	7157	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple_sclerosis .
15467736	0	HDAC4	0,5	PLZF	98,102	HDAC4	PLZF	9759	7704	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	HDAC4 mediates transcriptional repression by the acute_promyelocytic_leukaemia-associated protein PLZF .
26414199	0	HDAC4	0,5	SIRT1	17,22	HDAC4	SIRT1	9759	23411	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	HDAC4 stabilizes SIRT1 via Sumoylation SIRT1 to delay cellular senescence .
11304536	0	HDAC4	61,66	SMRTE	0,5	HDAC4	SMRTE	9759	9612	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains .
16293940	0	HDAC4	52,57	histone_deacetylase_4	29,50	HDAC4	histone deacetylase 4	208727(Tax:10090)	208727(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Stage specific expression of histone_deacetylase_4 -LRB- HDAC4 -RRB- during oogenesis and early preimplantation development in mice .
20097749	0	HDAC4	0,5	matrix_metalloproteinase-13	16,43	HDAC4	matrix metalloproteinase-13	363287(Tax:10116)	171052(Tax:10116)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	HDAC4 represses matrix_metalloproteinase-13 transcription in osteoblastic cells , and parathyroid_hormone controls this repression .
26437241	0	HDAC4	53,58	miR-22	13,19	HDAC4	miR-22	208727(Tax:10090)	387141(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell-dependent emphysema .
27022108	0	HDAC4	33,38	miR-29b	25,32	HDAC4	miR-29b	9759	407024	Gene	Gene	loop|compound|START_ENTITY loop|amod|END_ENTITY	Therapeutic targeting of miR-29b / HDAC4 epigenetic loop in multiple_myeloma .
18850004	0	HDAC4	0,5	p21	16,19	HDAC4	p21	9759	1026	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	HDAC4 represses p21 -LRB- WAF1/Cip1 -RRB- expression in human cancer cells through a Sp1-dependent , p53-independent mechanism .
19509297	0	HDAC4	0,5	vascular_endothelial_growth_factor	16,50	HDAC4	vascular endothelial growth factor	9759	7422	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	HDAC4 represses vascular_endothelial_growth_factor expression in chondrosarcoma by modulating RUNX2 activity .
14668799	0	HDAC5	23,28	GATA-1	34,40	HDAC5	GATA-1	15184(Tax:10090)	14460(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation .
18292392	0	HDAC5	14,19	GIT1	0,4	HDAC5	GIT1	10014	28964	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	GIT1 mediates HDAC5 activation by angiotensin_II in vascular smooth muscle cells .
20042720	0	HDAC5	74,79	KLF2	107,111	HDAC5	KLF2	10014	10365	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS .
18946175	0	HDAC5	16,21	SIK1	25,29	HDAC5	SIK1	15184(Tax:10090)	17691(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts .
25158672	0	HDAC5	106,111	YY-1	123,127	HDAC5	YY-1	84580(Tax:10116)	24919(Tax:10116)	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Antithetical Regulation of a-Myosin Heavy Chain Between Fetal and Adult Heart_Failure Though Shuttling of HDAC5 Regulating YY-1 Function .
18292392	0	HDAC5	14,19	angiotensin_II	34,48	HDAC5	angiotensin II	10014	183	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nmod|END_ENTITY	GIT1 mediates HDAC5 activation by angiotensin_II in vascular smooth muscle cells .
11018260	0	HDAC5	83,88	histone_deacetylase_5	55,76	HDAC5	histone deacetylase 5	10014	10014	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal organization and localization of the human histone_deacetylase_5 gene -LRB- HDAC5 -RRB- .
26765925	0	HDAC6	86,91	HIF-1a	122,128	HDAC6	HIF-1a	10013	3091	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|dobj|Activity Activity|compound|END_ENTITY	Class I and IIa HDACs Mediate HIF-1a Stability through PHD2-Dependent Mechanism while HDAC6 , a Class IIb Member , Promotes HIF-1a Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc .
26653328	0	HDAC6	106,111	Histone_Deacetylase_6	83,104	HDAC6	Histone Deacetylase 6	10013	10013	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Synthesis and Biological Investigation of Oxazole_Hydroxamates as Highly Selective Histone_Deacetylase_6 -LRB- HDAC6 -RRB- Inhibitors .
15916966	0	HDAC6	0,5	Hsp90	16,21	HDAC6	Hsp90	10013	3320	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|acetylation acetylation|amod|END_ENTITY	HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid_receptor .
19158084	0	HDAC6	0,5	Hsp90	16,21	HDAC6	Hsp90	10013	3320	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl_hydrocarbon_receptor signaling .
19855091	0	HDAC6	0,5	Hsp90	91,96	HDAC6	Hsp90	15185(Tax:10090)	104434(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|hypersensitivity hypersensitivity|acl|modulating modulating|dobj|acetylation acetylation|amod|END_ENTITY	HDAC6 regulates androgen_receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant_prostate_cancer .
21082217	0	HDAC6	86,91	Hsp90	120,125	HDAC6	Hsp90	10013	3320	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Carbamazepine promotes Her-2 protein degradation in breast_cancer cells by modulating HDAC6 activity and acetylation of Hsp90 .
26775640	0	HDAC6	18,23	PD-L1	45,50	HDAC6	PD-L1	100621798	574058(Tax:9823)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Essential role of HDAC6 in the regulation of PD-L1 in melanoma .
25070956	0	HDAC6	18,23	Paxillin	0,8	HDAC6	Paxillin	10013	5829	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Paxillin inhibits HDAC6 to regulate microtubule acetylation , Golgi structure , and polarized migration .
25546293	0	HDAC6	0,5	b-Catenin	73,82	HDAC6	b-Catenin	10013	1499	Gene	Gene	Acetylation|compound|START_ENTITY Acetylation|nmod|END_ENTITY	HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of b-Catenin in Human iPSC-Derived Neuronal Cells .
23152903	0	HDAC6	0,5	epidermal_growth_factor_receptor	16,48	HDAC6	epidermal growth factor receptor	15185(Tax:10090)	13649(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HDAC6 regulates epidermal_growth_factor_receptor -LRB- EGFR -RRB- endocytic trafficking and degradation in renal epithelial cells .
18591380	0	HDAC6	0,5	hsp90	57,62	HDAC6	hsp90	10013	3320	Gene	Gene	inhibition|compound|START_ENTITY enhances|nsubj|inhibition enhances|parataxis|function function|nsubj|abrogation abrogation|nmod|chaperone chaperone|amod|END_ENTITY	HDAC6 inhibition enhances 17-AAG -- mediated abrogation of hsp90 chaperone function in human leukemia cells .
16192271	0	HDAC6	0,5	huntingtin	77,87	HDAC6	huntingtin	10013	3064	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|degradation degradation|nmod|END_ENTITY	HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin .
16860317	0	HDAC7	92,97	Androgen_receptor	0,17	HDAC7	Androgen receptor	51564	367	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Androgen_receptor regulates nuclear trafficking and nuclear domain residency of corepressor HDAC7 in a ligand-dependent fashion .
12753745	0	HDAC7	0,5	Nur77	65,70	HDAC7	Nur77	51564	3164	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	HDAC7 , a thymus-specific class II histone deacetylase , regulates Nur77 transcription and TCR-mediated apoptosis .
15623513	0	HDAC7	33,38	Protein_kinase_D1	0,17	HDAC7	Protein kinase D1	56233(Tax:10090)	18760(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Protein_kinase_D1 phosphorylates HDAC7 and induces its nuclear export after T-cell_receptor activation .
15623513	0	HDAC7	33,38	T-cell_receptor	76,91	HDAC7	T-cell receptor	56233(Tax:10090)	328483(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Protein_kinase_D1 phosphorylates HDAC7 and induces its nuclear export after T-cell_receptor activation .
18617643	0	HDAC7	16,21	VEGF	0,4	HDAC7	VEGF	51564	7422	Gene	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis .
18506539	0	HDAC7	28,33	histone_deacetylase_7	5,26	HDAC7	histone deacetylase 7	51564	51564	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	High histone_deacetylase_7 -LRB- HDAC7 -RRB- expression is significantly associated with adenocarcinomas of the pancreas .
24561820	0	HDAC8	160,165	histone_deacetylase	139,158	HDAC8	histone deacetylase	55869	55869	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis , molecular docking and cytotoxicity evaluation of novel 2 - -LRB- 4-amino-benzosulfonyl -RRB- -5 H-benzo -LSB- b -RSB- carbazole-6 ,11 - dione derivatives as histone_deacetylase -LRB- HDAC8 -RRB- inhibitors .
17101791	0	HDAC9	14,19	MEF2	39,43	HDAC9	MEF2	9734	4205	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation .
12054582	0	HDAC9	83,88	histone_deacetylase_9	55,76	HDAC9	histone deacetylase 9	9734	9734	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal organization and localization of the human histone_deacetylase_9 gene -LRB- HDAC9 -RRB- .
15021979	0	HDC	53,56	L-histidine_decarboxylase	26,51	HDC	L-histidine decarboxylase	15186(Tax:10090)	15186(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Different patterns of the L-histidine_decarboxylase -LRB- HDC -RRB- gene expression in mice resistant and susceptible to experimental cutaneous_leishmaniasis .
10888469	0	HDC	29,32	histidine_decarboxylase	4,27	HDC	histidine decarboxylase	3067	3067	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The histidine_decarboxylase -LRB- HDC -RRB- gene of Tetrahymena_pyriformis is similar to the mammalian one .
22682760	0	HDGF	60,64	hepatoma-derived_growth_factor	28,58	HDGF	hepatoma-derived growth factor	3068	3068	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of nuclear hepatoma-derived_growth_factor -LRB- HDGF -RRB- localization in patients with breast_cancer .
23609195	0	HDGF	60,64	hepatoma-derived_growth_factor	28,58	HDGF	hepatoma-derived growth factor	3068	3068	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Downregulated expression of hepatoma-derived_growth_factor -LRB- HDGF -RRB- reduces gallbladder_cancer cell proliferation and invasion .
24891187	0	HDGF	16,20	miR-195	0,7	HDGF	miR-195	3068	406971	Gene	Gene	START_ENTITY|nsubj|Targets Targets|amod|END_ENTITY	miR-195 Targets HDGF to inhibit proliferation and invasion of NSCLC cells .
22006999	0	HDGF	52,56	p53	0,3	HDGF	p53	3068	7157	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p53 negatively regulates the hepatoma growth factor HDGF .
15177283	0	HDJ-1	99,104	cytochrome_P450_1A2	31,50	HDJ-1	cytochrome P450 1A2	3337	1544	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	High-level expression of human cytochrome_P450_1A2 by co-expression with human molecular chaperone HDJ-1 -LRB- Hsp40 -RRB- .
2445254	0	HDL2	77,81	HDL3	82,86	HDL2	HDL3	57338	53369	Gene	Gene	START_ENTITY|dep|ratios ratios|nummod|END_ENTITY	Further evidence for the heterogeneity of high density lipoprotein isolates : HDL2 : HDL3 cholesterol ratios and the presence of apolipoprotein_B .
2445254	0	HDL3	82,86	HDL2	77,81	HDL3	HDL2	53369	57338	Gene	Gene	ratios|nummod|START_ENTITY END_ENTITY|dep|ratios	Further evidence for the heterogeneity of high density lipoprotein isolates : HDL2 : HDL3 cholesterol ratios and the presence of apolipoprotein_B .
15001457	0	HDL3	0,4	cyclooxygenase-2	13,29	HDL3	cyclooxygenase-2	53369	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway : effects on COX-2 / PGI-synthase coupling .
25230879	0	HDL3	0,4	paraoxonase_1	16,29	HDL3	paraoxonase 1	114576(Tax:10090)	18979(Tax:10090)	Gene	Gene	stimulates|compound|START_ENTITY END_ENTITY|nsubj|stimulates	HDL3 stimulates paraoxonase_1 antiatherogenic catalytic and biological activities in a macrophage model system : In vivo and in vitro studies .
20522601	0	HDL3	0,4	plasminogen_activator_inhibitor-1	31,64	HDL3	plasminogen activator inhibitor-1	53369	5054	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	HDL3 , but not HDL2 , stimulates plasminogen_activator_inhibitor-1 release from adipocytes : the role of sphingosine-1-phosphate .
24240108	0	HDM2	0,4	AURKA	19,24	HDM2	AURKA	4193	6790	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	HDM2 regulation by AURKA promotes cell survival in gastric_cancer .
11960368	0	HDM2	19,23	Akt	27,30	HDM2	Akt	4193	207	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of HDM2 by Akt .
15144954	0	HDM2	37,41	NPM	18,21	HDM2	NPM	4193	4869	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation .
26366217	0	HDM2	83,87	NUMB	31,35	HDM2	NUMB	4193	8650	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	The Expression and Function of NUMB in Endometrial_Cancer and the Interaction with HDM2 and P53 .
20438709	0	HDM2	27,31	Phospholipase_D	0,15	HDM2	Phospholipase D	4193	2822	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Phospholipase_D stabilizes HDM2 through an mTORC2/SGK1 pathway .
22912717	0	HDM2	81,85	Translationally_Controlled_Tumour_Protein	11,52	HDM2	Translationally Controlled Tumour Protein	4193	7178	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Binding of Translationally_Controlled_Tumour_Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3 .
10980695	0	HDM2	10,14	p53	71,74	HDM2	p53	4193	7157	Gene	Gene	intact|dep|START_ENTITY domain|amod|intact required|nsubjpass|domain required|nmod|exclusion exclusion|nmod|END_ENTITY	An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 .
11279110	0	HDM2	16,20	p53	58,61	HDM2	p53	4193	7157	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|degradation degradation|nmod|END_ENTITY	Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma .
11494132	0	HDM2	25,29	p53	48,51	HDM2	p53	4193	7157	Gene	Gene	product|compound|START_ENTITY increases|nsubj|product increases|dobj|activity activity|compound|END_ENTITY	An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2 .
11494132	0	HDM2	75,79	p53	48,51	HDM2	p53	4193	7157	Gene	Gene	inhibiting|dobj|START_ENTITY increases|advcl|inhibiting increases|dobj|activity activity|compound|END_ENTITY	An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2 .
15314174	0	HDM2	14,18	p53	37,40	HDM2	p53	4193	7157	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of HDM2 and activation of p53 by ribosomal_protein_L23 .
15693891	0	HDM2	0,4	p53	76,79	HDM2	p53	4193	7157	Gene	Gene	overexpression|compound|START_ENTITY deregulate|nsubj|overexpression deregulate|dobj|suppressor suppressor|compound|END_ENTITY	HDM2 overexpression and focal loss of p14/ARF expression may deregulate the p53 tumour suppressor pathway in meningeal_haemangiopericytomas .
15715460	0	HDM2	57,61	p53	88,91	HDM2	p53	4193	7157	Gene	Gene	antagonists|nummod|START_ENTITY that|nmod:npmod|antagonists activate|advmod|that activate|dobj|END_ENTITY	Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells .
15862297	0	HDM2	0,4	p53	61,64	HDM2	p53	4193	7157	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	HDM2 negatively affects the Chk2-mediated phosphorylation of p53 .
15950904	0	HDM2	29,33	p53	83,86	HDM2	p53	4193	7157	Gene	Gene	activity|compound|START_ENTITY inhibitors|nmod|activity stabilize|nsubj|inhibitors stabilize|dobj|END_ENTITY	Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells .
16360036	0	HDM2	12,16	p53	59,62	HDM2	p53	4193	7157	Gene	Gene	target|compound|START_ENTITY target|nmod|END_ENTITY	hnRNP_K : an HDM2 target and transcriptional coactivator of p53 in response to DNA damage .
16432196	0	HDM2	22,26	p53	62,65	HDM2	p53	4193	7157	Gene	Gene	region|nmod|START_ENTITY provides|nsubj|region provides|dobj|site site|nmod|END_ENTITY	The central region of HDM2 provides a second binding site for p53 .
17698841	0	HDM2	98,102	p53	17,20	HDM2	p53	4193	7157	Gene	Gene	sequestration|nmod|START_ENTITY associated|nmod|sequestration associated|nsubjpass|Stabilization Stabilization|nmod|END_ENTITY	Stabilization of p53 in human_cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination .
19433585	0	HDM2	88,92	p53	69,72	HDM2	p53	4193	7157	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage .
19880322	0	HDM2	30,34	p53	55,58	HDM2	p53	4193	7157	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|amod|binding binding|nmod|END_ENTITY	N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53 .
20542919	0	HDM2	23,27	p53	41,44	HDM2	p53	4193	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|attenuate attenuate|dobj|degradation degradation|compound|END_ENTITY	Negative regulation of HDM2 to attenuate p53 degradation by ribosomal_protein_L26 .
21993556	0	HDM2	19,23	p53	0,3	HDM2	p53	4193	7157	Gene	Gene	antagonism|compound|START_ENTITY rescue|nmod|antagonism rescue|compound|END_ENTITY	p53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition .
22989009	0	HDM2	0,4	p53	87,90	HDM2	p53	4193	7157	Gene	Gene	MI-219|compound|START_ENTITY regulates|nsubj|MI-219 regulates|dobj|END_ENTITY	HDM2 antagonist MI-219 -LRB- spiro-oxindole -RRB- , but not Nutlin-3 -LRB- cis-imidazoline -RRB- , regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant_B-cell_lymphomas .
22989009	0	HDM2	108,112	p53	87,90	HDM2	p53	4193	7157	Gene	Gene	autoubiquitination|compound|START_ENTITY regulates|nmod|autoubiquitination regulates|dobj|END_ENTITY	HDM2 antagonist MI-219 -LRB- spiro-oxindole -RRB- , but not Nutlin-3 -LRB- cis-imidazoline -RRB- , regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant_B-cell_lymphomas .
24113239	0	HDM2	65,69	p53	43,46	HDM2	p53	4193	7157	Gene	Gene	ubiquitination|nmod|START_ENTITY ubiquitination|nsubj|derivatives derivatives|nmod|inhibitors inhibitors|nmod|END_ENTITY	5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2 .
24314634	0	HDM2	73,77	p53	44,47	HDM2	p53	4193	7157	Gene	Gene	motif|nmod|START_ENTITY BOX|xcomp|motif BOX|nsubj|END_ENTITY	Human_herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization .
12842086	0	HDM2	14,18	ribosomal_protein_L11	35,56	HDM2	ribosomal protein L11	4193	6135	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of HDM2 activity by the ribosomal_protein_L11 .
15314174	0	HDM2	14,18	ribosomal_protein_L23	44,65	HDM2	ribosomal protein L23	4193	9349	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of HDM2 and activation of p53 by ribosomal_protein_L23 .
11280734	0	HDMX	23,27	p53	78,81	HDMX	p53	4194	7157	Gene	Gene	proteins|compound|START_ENTITY expression|nmod|proteins correlates|nsubj|expression correlates|nmod|END_ENTITY	Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53 .
20472715	0	HDMX	0,4	p53	15,18	HDMX	p53	4193	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	HDMX regulates p53 activity and confers chemoresistance to 3-bis -LRB- 2-chloroethyl -RRB- -1 - nitrosourea .
22700878	0	HDMX	40,44	p53	89,92	HDMX	p53	4194	7157	Gene	Gene	splicing|nmod|START_ENTITY offers|nsubj|splicing offers|nmod|mutation mutation|compound|END_ENTITY	Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer .
24813712	0	HDMX	0,4	p53	23,26	HDMX	p53	4193	7157	Gene	Gene	folds|nsubj|START_ENTITY folds|dobj|mRNA mRNA|compound|END_ENTITY	HDMX folds the nascent p53 mRNA following activation by the ATM kinase .
22284961	0	HE4	6,9	CA125	51,56	HE4	CA125	10406	94025	Gene	Gene	elevated|nsubj|START_ENTITY elevated|dobj|END_ENTITY	Serum HE4 levels are less frequently elevated than CA125 in women with benign_gynecologic_disorders .
12839961	0	HE4	4,7	WFDC2	9,14	HE4	WFDC2	10406	10406	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The HE4 -LRB- WFDC2 -RRB- protein is a biomarker for ovarian_carcinoma .
26575020	0	HE4	18,21	human_epididymis_protein_4	23,49	HE4	human epididymis protein 4	10406	10406	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of HE4 -LRB- human_epididymis_protein_4 -RRB- enhances proliferation , invasion and metastasis of ovarian_cancer .
9291477	0	HE5	50,53	CD52	44,48	HE5	CD52	1043	1043	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the human epididymal protein CD52 -LRB- HE5 -RRB- with epididymal spermatozoa from men and cynomolgus_monkeys .
21832156	0	HEC1	46,50	Ndc80	23,28	HEC1	Ndc80	10403	10403	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Phosphorylation of the Ndc80 complex protein , HEC1 , by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint .
11118211	0	HEF1	84,88	Smad3	19,24	HEF1	Smad3	4739	4088	Gene	Gene	degradation|nmod|START_ENTITY regulate|dobj|degradation ability|acl|regulate ability|nmod|END_ENTITY	A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1 .
15144564	0	HEF1	85,89	Smad3	27,32	HEF1	Smad3	4739	4088	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction between Smad3 , APC10 , CDH1 and HEF1 in proteasomal degradation of HEF1 .
12214280	0	HELAD1	13,19	helicase	35,43	HELAD1	helicase	89797	164045	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Isolation of HELAD1 , a novel human helicase gene up-regulated in colorectal_carcinomas .
23525231	0	HELZ2	22,27	THRAP3	0,6	HELZ2	THRAP3	229003(Tax:10090)	230753(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation .
20345897	0	HEM13	33,38	Ixr1p	0,5	HEM13	Ixr1p	851614(Tax:4932)	853836(Tax:4932)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Ixr1p regulates oxygen-dependent HEM13 transcription .
8593679	0	HEM13	97,102	coproporphyrinogen_oxidase	109,135	HEM13	coproporphyrinogen oxidase	851614(Tax:4932)	851614(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene -LRB- coproporphyrinogen_oxidase -RRB- in Saccharomyces_cerevisiae .
12878195	0	HEN1	68,72	LMO4	21,25	HEN1	LMO4	4807	8543	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	The LIM-only protein LMO4 modulates the transcriptional activity of HEN1 .
17606638	0	HEN1	33,37	Pimet	0,5	HEN1	Pimet	36301(Tax:7227)	36301(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Pimet , the Drosophila homolog of HEN1 , mediates 2 ' - O-methylation of Piwi - interacting RNAs at their 3 ' ends .
21573214	0	HEN2	33,37	LMO3	10,14	HEN2	LMO3	4808	55885	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1 .
18420590	0	HEP2	42,46	HSP70B	67,73	HEP2	HSP70B	5717182(Tax:3055)	5722220(Tax:3055)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Assistance for a chaperone : Chlamydomonas HEP2 activates plastidic HSP70B for cochaperone binding .
18256281	0	HEPL	27,31	Cas	8,11	HEPL	Cas	57091	12927(Tax:10090)	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	A novel Cas family member , HEPL , regulates FAK and cell spreading .
25687183	0	HEPN1	94,99	MicroRNA-21	0,11	HEPN1	MicroRNA-21	641654	406991	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-21 promotes cell proliferation in human hepatocellular_carcinoma partly by targeting HEPN1 .
2462418	0	HER-1	70,75	EGF_receptor	56,68	HER-1	EGF receptor	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Effects of 8-methoxypsoralen and ultraviolet light A on EGF_receptor -LRB- HER-1 -RRB- expression .
10467326	0	HER-2	23,28	C-erbB-2	14,22	HER-2	C-erbB-2	2064	2064	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of C-erbB-2 / HER-2 in patients with metastatic breast_cancer undergoing high-dose_chemotherapy and autologous blood stem cell support .
19144272	0	HER-2	60,65	CD8	19,22	HER-2	CD8	2064	925	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	CCL16 enhances the CD8 + and CD4 + T cell reactivity to human HER-2 elicited by dendritic cells loaded with rat ortholog HER-2 .
15068324	0	HER-2	0,5	COX-2	13,18	HER-2	COX-2	2064	4513	Gene	Gene	status|compound|START_ENTITY status|amod|END_ENTITY	HER-2 , EGFR , COX-2 expression status correlated to microvessel density and survival in resected non-small cell lung_cancer .
15842638	0	HER-2	49,54	COX-2	0,5	COX-2	COX-2	4513	4513	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|compound|END_ENTITY	COX-2 expression in DCIS : correlation with VEGF , HER-2 / neu , prognostic molecular markers and clinicopathological features .
11901151	0	HER-2	37,42	Cyclooxygenase-2	0,16	HER-2	Cyclooxygenase-2	2064	5743	Gene	Gene	evidence|compound|START_ENTITY overexpressed|nmod|evidence overexpressed|nsubjpass|END_ENTITY	Cyclooxygenase-2 is overexpressed in HER-2 / neu-positive breast_cancer : evidence for involvement of AP-1 and PEA3 .
14744769	0	HER-2	34,39	Cyclooxygenase-2	0,16	HER-2	Cyclooxygenase-2	2064	5743	Gene	Gene	EP1|dep|START_ENTITY EP1|compound|END_ENTITY	Cyclooxygenase-2 induces EP1 - and HER-2 / Neu-dependent vascular_endothelial_growth_factor-C up-regulation : a novel mechanism of lymphangiogenesis in lung_adenocarcinoma .
11495584	0	HER-2	176,181	EGFR	126,130	HER-2	EGFR	2064	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	6-Substituted-4 - -LRB- 3-bromophenylamino -RRB- quinazolines as putative irreversible inhibitors of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and human epidermal_growth_factor_receptor -LRB- HER-2 -RRB- tyrosine kinases with enhanced antitumor activity .
12502359	1	HER-2	288,293	EGFR	232,236	HER-2	EGFR	2064	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	The design of an orally active , irreversible inhibitor of the tyrosine kinase activity of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and the human epidermal_growth_factor_receptor-2 -LRB- HER-2 -RRB- .
15112275	0	HER-2	30,35	ErbB-2	36,42	HER-2	ErbB-2	2064	2064	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|END_ENTITY	Evaluation of P-glycoprotein , HER-2 / ErbB-2 , p53 , and Bcl-2 in primary_tumor and metachronous lung metastases in patients with high-grade osteosarcoma .
8999872	0	HER-2	64,69	ErbB-2	70,76	HER-2	ErbB-2	2064	2064	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association of csk-homologous_kinase -LRB- CHK -RRB- -LRB- formerly MATK -RRB- with HER-2 / ErbB-2 in breast_cancer cells .
19918269	0	HER-2	13,18	HER-2	56,61	HER-2	HER-2	2064	2064	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduction in HER-2 protein expression in a breast_tumor HER-2 positive after only one injection of Trastuzumab : a case report .
19918269	0	HER-2	56,61	HER-2	13,18	HER-2	HER-2	2064	2064	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduction in HER-2 protein expression in a breast_tumor HER-2 positive after only one injection of Trastuzumab : a case report .
15888257	0	HER-2	130,135	NEU	136,139	HER-2	NEU	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	A limited autoimmunity to p185neu elicited by DNA and allogeneic cell vaccine hampers the progression of preneoplastic_lesions in HER-2 / NEU transgenic_mice .
17626754	0	HER-2	17,22	PCNA	24,28	HER-2	PCNA	2064	5111	Gene	Gene	Bcl-2|compound|START_ENTITY Bcl-2|dep|END_ENTITY	-LSB- Correlations of HER-2 , PCNA , Bcl-2 , and Bax expression to prognosis of breast_cancer -RSB- .
20179161	0	HER-2	35,40	Pin1	21,25	HER-2	Pin1	2064	5300	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1 .
22983836	0	HER-2	41,46	VP1	26,29	HER-2	VP1	2064	65130(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast_cancer .
24191589	0	HER-2	52,57	androgen_receptor	66,83	HER-2	androgen receptor	2064	367	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	-LSB- Survival analysis and immunohistochemical study of HER-2 and AR -LRB- androgen_receptor -RRB- expression in salivary_duct_carcinoma -RSB- .
22582394	0	HER-2	0,5	biglycan	38,46	HER-2	biglycan	2064	633	Gene	Gene	down-regulation|compound|START_ENTITY down-regulation|nmod|END_ENTITY	HER-2 / neu-mediated down-regulation of biglycan associated with altered growth properties .
10560479	0	HER-2	41,46	c-erbB-2	31,39	HER-2	c-erbB-2	2064	2064	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Semiquantitative assessment of c-erbB-2 -LRB- HER-2 -RRB- status in cytology specimens and tissue sections from breast_carcinoma .
8999872	0	HER-2	64,69	csk-homologous_kinase	15,36	HER-2	csk-homologous kinase	2064	4145	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of csk-homologous_kinase -LRB- CHK -RRB- -LRB- formerly MATK -RRB- with HER-2 / ErbB-2 in breast_cancer cells .
14985703	0	HER-2	14,19	cyclooxygenase-2	43,59	HER-2	cyclooxygenase-2	2064	5743	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin_E2 .
1354348	0	HER-2	37,42	epidermal_growth_factor_receptor	67,99	HER-2	epidermal growth factor receptor	2064	1956	Gene	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Transformation mediated by the human HER-2 gene independent of the epidermal_growth_factor_receptor .
10765127	0	HER-2	65,70	erbB-2	58,64	HER-2	erbB-2	2064	2064	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Vitamin_D_receptor gene BsmI polymorphism correlates with erbB-2 / HER-2 expression in human rectal_cancer .
19666946	0	HER-2	0,5	hormone_receptor	83,99	HER-2	hormone receptor	2064	3164	Gene	Gene	protein|compound|START_ENTITY shows|nsubj|protein shows|dobj|expression expression|compound|END_ENTITY	HER-2 protein overexpressing breast_cancer without gene amplification shows higher hormone_receptor expression than HER-2 protein overexpressing breast_cancer with gene amplification .
19666946	0	HER-2	116,121	hormone_receptor	83,99	HER-2	hormone receptor	2064	3164	Gene	Gene	protein|compound|START_ENTITY shows|nmod|protein shows|dobj|expression expression|compound|END_ENTITY	HER-2 protein overexpressing breast_cancer without gene amplification shows higher hormone_receptor expression than HER-2 protein overexpressing breast_cancer with gene amplification .
20138441	0	HER-2	20,25	hormone_receptor	38,54	HER-2	hormone receptor	2064	3164	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Concordance between HER-2 and steroid hormone_receptor expression between primary breast_cancer , sentinel node metastases , and isolated_tumor cells .
10800094	0	HER-2	135,140	neu	141,144	HER-2	neu	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary_tumors in HER-2 / neu transgenic_mice .
11696586	0	HER-2	106,111	neu	112,115	HER-2	neu	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Combined_allogeneic_tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2 / neu transgenic_mice .
12691823	0	HER-2	89,94	neu	95,98	HER-2	neu	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Number of pregnancies and ovariectomy modify mammary_carcinoma development in transgenic HER-2 / neu female mice .
16224592	0	HER-2	65,70	neu	71,74	HER-2	neu	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Metformin decelerates aging and development of mammary_tumors in HER-2 / neu transgenic_mice .
18306859	0	HER-2	88,93	neu	94,97	HER-2	neu	2064	2064	Gene	Gene	START_ENTITY|appos|confers confers|nsubj|END_ENTITY	Recurrent pure mucinous_carcinoma of the breast with mediastinal great vessel invasion : HER-2 / neu confers aggressiveness .
24472145	0	HER-2	20,25	neu	26,29	HER-2	neu	2064	2064	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|END_ENTITY	Correlation between HER-2 / neu -LRB- erbB-2 -RRB- expression level and therapeutic effect of combination treatment with HERCEPTIN and chemotherapeutic agents in gastric_cancer cell lines .
25443643	0	HER-2	115,120	neu	121,124	HER-2	neu	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Sidestream dark field videomicroscopy for in vivo evaluation of vascularization and perfusion of mammary_tumors in HER-2 / neu transgenic_mice .
15221598	0	HER-2	35,40	p53	30,33	HER-2	p53	2064	7157	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation and expression of p53 , HER-2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and e-cadherin in a high-risk breast-cancer population .
12917021	0	HER-2	17,22	receptor_tyrosine_kinase	27,51	HER-2	receptor tyrosine kinase	2064	5979	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|parataxis|neu neu|dobj|phosphorylation phosphorylation|amod|END_ENTITY	-LSB- SUCI02 inhibits HER-2 / neu receptor_tyrosine_kinase phosphorylation and growth of HER-2 / neu-overexpressing breast_cancer cells -RSB- .
12917021	0	HER-2	82,87	receptor_tyrosine_kinase	27,51	HER-2	receptor tyrosine kinase	2064	5979	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	-LSB- SUCI02 inhibits HER-2 / neu receptor_tyrosine_kinase phosphorylation and growth of HER-2 / neu-overexpressing breast_cancer cells -RSB- .
8626139	0	HER-2	52,57	receptor_tyrosine_kinase	62,86	HER-2	receptor tyrosine kinase	2064	5979	Gene	Gene	Transfection|nmod|START_ENTITY Transfection|parataxis|induces induces|nsubj|END_ENTITY	Transfection of human ovarian_cancer cells with the HER-2 / neu receptor_tyrosine_kinase induces a selective increase in PTP-H1 , PTP-1B , PTP-alpha expression .
16928826	0	HER-3	95,100	Akt	16,19	HER-3	Akt	2065	207	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Inactivation Inactivation|nmod|END_ENTITY	Inactivation of Akt by the epidermal_growth_factor_receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal_tumor cell lines and contributes to erlotinib sensitivity .
11526509	0	HER-3	84,89	EGF_receptor	132,144	HER-3	EGF receptor	2065	1956	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Expression of herstatin , an autoinhibitor of HER-2 / neu , inhibits transactivation of HER-3 by HER-2 and blocks EGF activation of the EGF_receptor .
10537356	0	HER-3	27,32	c-erbB-3	18,26	HER-3	c-erbB-3	2065	2065	Gene	Gene	receptors|dep|START_ENTITY receptors|amod|END_ENTITY	Expression of the c-erbB-3 / HER-3 and c-erbB-4 / HER-4 growth factor receptors and their ligands , neuregulin-1 alpha , neuregulin-1 beta , and betacellulin , in normal endometrium and endometrial_cancer .
22529914	0	HER1	59,63	CXCL12	0,6	HER1	CXCL12	1956	6387	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|dep|phosphorylation	CXCL12 and -LSB- N33A -RSB- CXCL12 in 5637 and HeLa cells : regulating HER1 phosphorylation via calmodulin/calcineurin .
21293538	0	HER1	60,64	EGFR	66,70	HER1	EGFR	1956	1956	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Lapatinib in breast_cancer - the predictive significance of HER1 -LRB- EGFR -RRB- , HER2 , PTEN and PIK3CA genes and lapatinib plasma level assessment .
15196531	0	HER2	14,18	AP-2	44,48	HER2	AP-2	2064	7020	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of HER2 and its association with AP-2 in breast_cancer .
14660651	0	HER2	23,27	BDP1	84,88	HER2	BDP1	2064	55814	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1 .
21044318	0	HER2	102,106	CD44	11,15	HER2	CD44	2064	960	Gene	Gene	functions|nmod|START_ENTITY +|nmod|functions +|nsubj|END_ENTITY	Increasing CD44 + / CD24 -LRB- - -RRB- tumor stem cells , and upregulation of COX-2 and HDAC6 , as major functions of HER2 in breast tumorigenesis .
21925125	0	HER2	0,4	CD44	20,24	HER2	CD44	2064	960	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric_cancer cells .
22565037	0	HER2	151,155	CD44	67,71	HER2	CD44	2064	960	Gene	Gene	+|compound|START_ENTITY trastuzumab|nmod|+ xenografts|amod|trastuzumab overcome|nmod|xenografts sufficient|xcomp|overcome initiating|parataxis|sufficient initiating|dobj|CD24 CD24|compound|END_ENTITY	Metformin-induced preferential killing of breast_cancer initiating CD44 + CD24 - / low cells is sufficient to overcome primary resistance to trastuzumab in HER2 + human breast_cancer xenografts .
18807177	0	HER2	75,79	CXCR4	54,59	HER2	CXCR4	2064	7852	Gene	Gene	overexpressing|nummod|START_ENTITY END_ENTITY|nmod|overexpressing	Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER2 overexpressing , estrogen_receptor-positive breast_cancer cells .
21925125	0	HER2	0,4	CXCR4	40,45	HER2	CXCR4	2064	7852	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric_cancer cells .
21185879	0	HER2	17,21	Calmodulin	0,10	HER2	Calmodulin	2064	808	Gene	Gene	HER2|compound|START_ENTITY binds|dobj|HER2 binds|nsubj|END_ENTITY	Calmodulin binds HER2 and modulates HER2 signaling .
21185879	0	HER2	36,40	Calmodulin	0,10	HER2	Calmodulin	2064	808	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Calmodulin binds HER2 and modulates HER2 signaling .
22377768	0	HER2	39,43	Calpain4	0,8	HER2	Calpain4	2064	826	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Calpain4 is required for activation of HER2 in breast_cancer cells exposed to trastuzumab and its suppression decreases survival and enhances response .
25342465	0	HER2	55,59	Cytokeratin19	0,13	HER2	Cytokeratin19	2064	3880	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes .
23027125	0	HER2	0,4	EGFR	16,20	HER2	EGFR	2064	1956	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling .
1675005	0	HER2	52,56	ERBB2	45,50	HER2	ERBB2	2064	2064	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	PCR detection of an MboI polymorphism in the ERBB2 -LRB- HER2 ; NEU -RRB- gene on chromosome 17q11.2-q12 .
23313108	0	HER2	10,14	ERBB2	16,21	HER2	ERBB2	2064	2064	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Change in HER2 -LRB- ERBB2 -RRB- gene status after taxane-based chemotherapy for breast_cancer : polyploidization can lead to diagnostic pitfalls with potential impact for clinical management .
23575477	0	HER2	100,104	ERBB2	106,111	HER2	ERBB2	2064	2064	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relapsed classic E-cadherin -LRB- CDH1 -RRB- - mutated invasive lobular_breast_cancer shows a high frequency of HER2 -LRB- ERBB2 -RRB- gene mutations .
12967566	0	HER2	27,31	ErbB-2	20,26	HER2	ErbB-2	2064	2064	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Polar expression of ErbB-2 / HER2 in epithelia .
15568014	0	HER2	23,27	ErbB-2	16,22	HER2	ErbB-2	2064	2064	Gene	Gene	signalling|nsubj|START_ENTITY END_ENTITY|parataxis|signalling	Hsp90 restrains ErbB-2 / HER2 signalling by limiting heterodimer formation .
12072561	0	HER2	35,39	ErbB2	28,33	HER2	ErbB2	2064	2064	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Conditional mutation of the ErbB2 -LRB- HER2 -RRB- receptor in cardiomyocytes leads to dilated_cardiomyopathy .
21499302	0	HER2	108,112	Farnesoid_X_receptor	0,20	HER2	Farnesoid X receptor	2064	9971	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression inhibits|nmod|downregulation inhibits|nsubj|END_ENTITY	Farnesoid_X_receptor inhibits tamoxifen-resistant MCF-7 breast_cancer cell growth through downregulation of HER2 expression .
11461069	0	HER2	87,91	GM-CSF	77,83	HER2	GM-CSF	2064	1437	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	A phase II study of the bispecific antibody MDX-H210 -LRB- anti-HER2 x CD64 -RRB- with GM-CSF in HER2 + advanced prostate_cancer .
20877352	0	HER2	78,82	GM-CSF	12,18	HER2	GM-CSF	2064	1437	Gene	Gene	patients|compound|START_ENTITY disease|nmod|patients stabilises|dobj|disease stabilises|nsubj|Addition Addition|nmod|trastuzumab trastuzumab|compound|END_ENTITY	Addition of GM-CSF to trastuzumab stabilises disease in trastuzumab-resistant HER2 + metastatic breast_cancer patients .
21803025	0	HER2	50,54	Growth_differentiation_factor_15	0,32	HER2	Growth differentiation factor 15	2064	9518	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|dep|phosphorylation	Growth_differentiation_factor_15 -LRB- GDF15 -RRB- - mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast_cancer cells .
25053886	0	HER2	31,35	HER2	89,93	HER2	HER2	2064	2064	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|status status|compound|END_ENTITY	Salivary expression of soluble HER2 in breast_cancer patients with positive and negative HER2 status .
25053886	0	HER2	89,93	HER2	31,35	HER2	HER2	2064	2064	Gene	Gene	status|compound|START_ENTITY expression|nmod|status expression|nmod|END_ENTITY	Salivary expression of soluble HER2 in breast_cancer patients with positive and negative HER2 status .
26047983	0	HER2	10,14	HER2	81,85	HER2	HER2	2064	2064	Gene	Gene	Effective|nsubj|START_ENTITY Effective|nmod|END_ENTITY	Targeting HER2 with T-DM1 , an Antibody Cytotoxic Drug Conjugate , is Effective in HER2 Over Expressing Bladder_Cancer .
26047983	0	HER2	81,85	HER2	10,14	HER2	HER2	2064	2064	Gene	Gene	Effective|nmod|START_ENTITY Effective|nsubj|END_ENTITY	Targeting HER2 with T-DM1 , an Antibody Cytotoxic Drug Conjugate , is Effective in HER2 Over Expressing Bladder_Cancer .
19758440	6	HER2	1696,1700	HR	1692,1694	HER2	HR	2064	3164	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Biology-based tumor type -LRB- P = 0.046 for HR + / HER2 + vs. HR + / HER2 - -RRB- , Ki67 labeling index -LRB- P = 0.028 -RRB- , and treatment arm -LRB- P = 0.036 -RRB- were independent predictors of pCR in a multivariate model .
26227964	0	HER2	90,94	HR	86,88	HER2	HR	2064	3164	Gene	Gene	_|compound|START_ENTITY breast_cancers|nsubj|_ axis|parataxis|breast_cancers axis|nmod|therapy therapy|nmod|END_ENTITY	Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR - / HER2 + _ breast_cancers .
22900205	0	HER2	71,75	Human_Epidermal_Growth_Factor_Receptor_2	29,69	HER2	Human Epidermal Growth Factor Receptor 2	2064	2064	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Relative Prognostic Value of Human_Epidermal_Growth_Factor_Receptor_2 -LRB- HER2 -RRB- Expression in Operable Oesophagogastric_Cancer .
26820945	0	HER2	56,60	Human_Epidermal_Growth_Factor_Receptor_2	14,54	HER2	Human Epidermal Growth Factor Receptor 2	2064	2064	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Evaluation of Human_Epidermal_Growth_Factor_Receptor_2 -LRB- HER2 -RRB- Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded -LRB- FFPE -RRB- Tissue Specimens by Fluorescence In Situ Hybridization -LRB- FISH -RRB- .
22092409	0	HER2	42,46	Human_epidermal_growth_factor_receptor_2	0,40	HER2	Human epidermal growth factor receptor 2	2064	2064	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Human_epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- immunoreactivity : specificity of three pharmacodiagnostic antibodies .
18262553	0	HER2	76,80	Leptin	0,6	HER2	Leptin	2064	3952	Gene	Gene	transactivation|nmod|START_ENTITY cells|nmod|transactivation proliferation|nmod|cells augments|dobj|proliferation augments|nsubj|END_ENTITY	Leptin augments proliferation of breast_cancer cells via transactivation of HER2 .
23228483	0	HER2	17,21	Leptin	0,6	HER2	Leptin	2064	3952	Gene	Gene	levels|nummod|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast_cancer cells .
22713243	0	HER2	16,20	Lin28	0,5	HER2	Lin28	2064	79727	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Lin28 regulates HER2 and promotes malignancy through multiple mechanisms .
23581225	0	HER2	26,30	PEA3	51,55	HER2	PEA3	2064	2118	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Simvastatin downregulates HER2 via upregulation of PEA3 to induce cell death in HER2-positive breast_cancer cells .
26729871	0	HER2	16,20	PMCA2	0,5	HER2	PMCA2	2064	491	Gene	Gene	localization|nummod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast_cancer .
15452162	0	HER2	39,43	SRC-1	110,115	HER2	SRC-1	2064	6714	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of SRC-1 , AIB1 , and PEA3 in HER2 mediated endocrine resistant breast_cancer ; a predictive role for SRC-1 .
15452162	0	HER2	39,43	SRC-1	14,19	HER2	SRC-1	2064	6714	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of SRC-1 , AIB1 , and PEA3 in HER2 mediated endocrine resistant breast_cancer ; a predictive role for SRC-1 .
19491269	0	HER2	35,39	TOB1	0,4	HER2	TOB1	2064	10140	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TOB1 is regulated by EGF-dependent HER2 and EGFR signaling , is highly phosphorylated , and indicates poor prognosis in node-negative_breast_cancer .
26124351	0	HER2	73,77	VEGFR1	37,43	HER2	VEGFR1	2064	2321	Gene	Gene	Status|compound|START_ENTITY Expression|nmod|Status Expression|compound|END_ENTITY	Prognostic Significance of VEGFC and VEGFR1 mRNA Expression According to HER2 Status in Breast_Cancer : A Study of Primary_Tumors from Patients with High-risk Early Breast_Cancer Participating in a Randomized Hellenic Cooperative Oncology Group Trial .
1357006	0	HER2	0,4	c-erbB-2	6,14	HER2	c-erbB-2	2064	2064	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	HER2 -LRB- c-erbB-2 -RRB- oncoprotein expression in colorectal_adenocarcinoma : an immunohistological study using three different antibodies .
14675323	0	HER2	36,40	c-erbB-2	27,35	HER2	c-erbB-2	2064	2064	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of c-erbB-2 / HER2 expression in advanced uterine cervical_carcinoma with para-aortic lymph node metastasis treated with radiation_therapy .
11417974	0	HER2	13,17	c-erbB2	5,12	HER2	c-erbB2	2064	2064	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|END_ENTITY	Does c-erbB2 / HER2 overexpression predict adjuvant tamoxifen failure in patients with early breast_cancer ?
23028798	0	HER2	55,59	class_III_beta_tubulin	18,40	HER2	class III beta tubulin	2064	10381	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Overexpression of class_III_beta_tubulin and amplified HER2 gene predict good response to paclitaxel and trastuzumab therapy .
11454885	0	HER2	43,47	epidermal_growth_factor_receptor	9,41	HER2	epidermal growth factor receptor	2064	1956	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	Value of epidermal_growth_factor_receptor , HER2 , p53 , and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast_cancer patients .
11167085	0	HER2	59,63	epidermal_growth_factor_receptor-2	23,57	HER2	epidermal growth factor receptor-2	2064	2064	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The value of the human epidermal_growth_factor_receptor-2 -LRB- HER2 -RRB- as a prognostic marker .
11342194	0	HER2	59,63	epidermal_growth_factor_receptor-2	23,57	HER2	epidermal growth factor receptor-2	2064	2064	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The value of the human epidermal_growth_factor_receptor-2 -LRB- HER2 -RRB- as a prognostic marker .
23379971	0	HER2	107,111	epidermal_growth_factor_receptor_2	71,105	HER2	epidermal growth factor receptor 2	2064	2064	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Validation of a new classifier for the automated analysis of the human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- gene amplification in breast_cancer specimens .
23744760	0	HER2	50,54	epidermal_growth_factor_receptor_2	14,48	HER2	epidermal growth factor receptor 2	2064	2064	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Soluble human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- levels in patients with HER2-positive breast_cancer receiving chemotherapy with or without trastuzumab : results from North Central Cancer Treatment Group adjuvant trial N9831 .
24393876	0	HER2	72,76	epidermal_growth_factor_receptor_2	36,70	HER2	epidermal growth factor receptor 2	2064	2064	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	-LSB- Clinical significance of the human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- in patients with recurrent gastric_cancer who received S-1 adjuvant chemotherapy -RSB- .
1681519	0	HER2	64,68	erbB-2	57,63	HER2	erbB-2	2064	2064	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	G to A polymorphism at amino_acid codon 655 of the human erbB-2 / HER2 gene .
19106626	0	HER2	43,47	erbB-2	49,55	HER2	erbB-2	2064	2064	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	The antidiabetic drug metformin suppresses HER2 -LRB- erbB-2 -RRB- oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast_carcinoma cells .
23928534	0	HER2	60,64	fatty_acid_synthase	15,34	HER2	fatty acid synthase	2064	2194	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of fatty_acid_synthase and its association with HER2 in invasive_ductal_carcinoma of breast -RSB- .
26077887	0	HER2	79,83	glycoprotein_nonmetastatic_B	25,53	HER2	glycoprotein nonmetastatic B	2064	10457	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of glycoprotein_nonmetastatic_B and its association with HER2 in breast_cancer .
23261058	0	HER2	0,4	leptin	27,33	HER2	leptin	2064	3952	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	HER2 induces expression of leptin in human breast epithelial cells .
17604627	0	HER2	54,58	p53	21,24	HER2	p53	2064	7157	Gene	Gene	signaling|compound|START_ENTITY expression|nmod|signaling expression|compound|END_ENTITY	Relationship between p53 and p27 expression following HER2 signaling .
12912973	0	HER2	0,4	peroxisome_proliferator-activated_receptor_gamma	19,67	HER2	peroxisome proliferator-activated receptor gamma	2064	5468	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	HER2 regulation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression and sensitivity of breast_cancer cells to PPARgamma ligand therapy .
16847283	0	HER2/Neu	53,61	ErbB2	63,68	HER2/Neu	ErbB2	2064	2064	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Can trastuzumab be effective against tumors with low HER2/Neu -LRB- ErbB2 -RRB- receptors ?
11478488	0	HER2/Neu	32,40	bFGF	85,89	HER2/Neu	bFGF	2064	2247	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF , TGF-beta , and PDGF in bile from biliary malignancies and inflammatory_disorders .
21849469	0	HER2/Neu	93,101	protein-tyrosine_phosphatase_1B	11,42	HER2/Neu	protein-tyrosine phosphatase 1B	13866(Tax:10090)	19246(Tax:10090)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Epithelial protein-tyrosine_phosphatase_1B contributes to the induction of mammary_tumors by HER2/Neu but is not essential for tumor maintenance .
14612949	0	HER2/neu	0,8	Akt	14,17	HER2/neu	Akt	2064	207	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	HER2/neu uses Akt to suppress retinoic_acid response element binding activity in MDA-MB-453 breast_cancer cells .
17721278	0	HER2/neu	122,130	ErbB2	115,120	HER2/neu	ErbB2	2064	2064	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	PGDS , a novel technique combining chromogenic in situ hybridization and immunohistochemistry for the assessment of ErbB2 -LRB- HER2/neu -RRB- status in breast_cancer .
23585570	0	HER2/neu	13,21	HIF-1	68,73	HER2/neu	HIF-1	2064	3091	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	The oncogene HER2/neu -LRB- ERBB2 -RRB- requires the hypoxia-inducible factor HIF-1 for mammary_tumor growth and anoikis resistance .
12013529	0	HER2/neu	21,29	c-erbB-2	12,20	HER2/neu	c-erbB-2	2064	2064	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of c-erbB-2 / HER2/neu in breast_cancer progression and metastasis .
17641798	0	HER2/neu	27,35	c-erbB-2	17,25	HER2/neu	c-erbB-2	2064	2064	Gene	Gene	status|compound|START_ENTITY status|amod|END_ENTITY	Angiogenesis and c-erbB-2 -LRB- HER2/neu -RRB- overexpression status in primary breast_cancer patients : an analysis of 158 needle core biopsies .
19050794	0	HER2/neu	50,58	c-erbB-2	40,48	HER2/neu	c-erbB-2	2064	2064	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Angiogenesis and co-expressed of ER and c-erbB-2 -LRB- HER2/neu -RRB- protein in primary breast_cancer patients : an analysis of 158 needle core biopsies .
23818346	0	HER2/neu	69,77	estrogen_receptor	27,44	HER2/neu	estrogen receptor	2064	2099	Gene	Gene	Ki-67|dep|START_ENTITY Ki-67|compound|END_ENTITY	Prognostic significance of estrogen_receptor , progesterone_receptor , HER2/neu , Ki-67 , and nm23 expression in patients with invasive_breast_cancer .
10471520	0	HER2/neu	40,48	p185	89,93	HER2/neu	p185	2064	8661	Gene	Gene	c-erb_B-2|appos|START_ENTITY analysis|nmod|c-erb_B-2 PCR|dep|analysis PCR|dep|amplification amplification|nmod|END_ENTITY	Quantitative PCR analysis of c-erb_B-2 -LRB- HER2/neu -RRB- gene amplification and comparison with p185 -LRB- HER2/neu -RRB- protein expression in breast_cancer drill biopsies .
25109965	0	HER3	28,32	EGFR	68,72	HER3	EGFR	2065	1956	Gene	Gene	START_ENTITY|nmod|resistance resistance|nmod|END_ENTITY	A role for the pseudokinase HER3 in the acquired resistance against EGFR - and HER2-directed targeted therapy .
21368164	0	HER3	25,29	ErbB3	31,36	HER3	ErbB3	2065	2065	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Feedback upregulation of HER3 -LRB- ErbB3 -RRB- expression and activity attenuates antitumor effect of PI3K inhibitors .
21385943	0	HER3	55,59	ErbB3	61,66	HER3	ErbB3	2065	2065	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Transcriptional and posttranslational up-regulation of HER3 -LRB- ErbB3 -RRB- compensates for inhibition of the HER2 tyrosine kinase .
16416603	0	HER3	28,32	cyclooxygenase-2	51,67	HER3	cyclooxygenase-2	2065	5743	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon_cancer cells .
19276373	0	HER3	23,27	microRNA-205	0,12	HER3	microRNA-205	2065	406988	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	microRNA-205 regulates HER3 in human breast_cancer .
22535374	0	HER3	112,116	neuregulin_1	99,111	HER3	neuregulin 1	2065	3084	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Bone marrow-derived mesenchymal stem cells promote colorectal_cancer_progression through paracrine neuregulin_1 / HER3 signalling .
23328545	0	HER3	64,68	neuregulin_1	51,63	HER3	neuregulin 1	2065	3084	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Spheroid culture of primary lung_cancer cells with neuregulin_1 / HER3 pathway activation .
19047365	0	HER4	49,53	WWP1	24,28	HER4	WWP1	2066	11059	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation .
21775519	0	HERC2	0,5	Claspin	21,28	HERC2	Claspin	8924	63967	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression .
24778179	0	HERC2	0,5	FBXL5	33,38	HERC2	FBXL5	8924	26234	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism .
18172690	0	HERC2	125,130	OCA2	147,151	HERC2	OCA2	8924	4948	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression .
24722987	0	HERC2	32,37	p53	78,81	HERC2	p53	8924	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization .
10790218	0	HERG	28,32	KCNH2	22,27	HERG	KCNH2	3757	3757	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of the human KCNH2 -LRB- HERG -RRB- gene : identification and characterization of a novel mutation Y667X associated with long_QT_syndrome and a non-pathological 9 bp insertion .
12736144	0	HERG	34,38	KCNH2	27,32	HERG	KCNH2	3757	3757	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of KCNH2 -LRB- HERG -RRB- in the human jejunum .
19765650	0	HERG	31,35	KCNH2	37,42	HERG	KCNH2	3757	3757	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and significance of HERG -LRB- KCNH2 -RRB- potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration .
19859662	0	HERG	14,18	KCNH2	20,25	HERG	KCNH2	3757	3757	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of HERG -LRB- KCNH2 -RRB- potassium channel surface expression by diacylglycerol .
14998624	0	HERG	67,71	KCNQ1	109,114	HERG	KCNQ1	3757	3784	Gene	Gene	START_ENTITY|nmod|mutations mutations|nummod|END_ENTITY	Long_QT_syndrome in neonates : conduction_disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations .
15090700	0	HERG	69,73	LQT2	63,67	HERG	LQT2	3757	3757	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Long-term follow-up of notched T waves in female patients with LQT2 -LRB- HERG -RRB- mutations .
18923542	0	HERG	49,53	caveolin-1	58,68	HERG	caveolin-1	3757	857	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	The regulation of the cardiac potassium channel -LRB- HERG -RRB- by caveolin-1 .
11741889	0	HERP1	0,5	Notch	48,53	HERP1	Notch	155430(Tax:10116)	25496(Tax:10116)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	HERP1 is a cell type-specific primary target of Notch .
9458354	0	HERV-R	48,54	ERV3	42,46	HERV-R	ERV3	2086	2086	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression of human endogenous retrovirus ERV3 -LRB- HERV-R -RRB- mRNA in normal and neoplastic tissues .
12620933	0	HERV-W	51,57	PEG10	81,86	HERV-W	PEG10	30816	23089	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Temporal regulation of the expression of syncytin -LRB- HERV-W -RRB- , maternally imprinted PEG10 , and SGCE in human placenta .
11098153	0	HES-1	37,42	P19	62,65	HES-1	P19	15205(Tax:10090)	83430(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	A novel cis-acting element regulates HES-1 gene expression in P19 embryonal_carcinoma cells treated with retinoic_acid .
22036964	0	HES-1	25,30	insulin_degrading_enzyme	49,73	HES-1	insulin degrading enzyme	3280	3416	Gene	Gene	bind|amod|START_ENTITY bind|acl|END_ENTITY	Notch signaling proteins HES-1 and Hey-1 bind to insulin_degrading_enzyme -LRB- IDE -RRB- proximal promoter and repress its transcription and activity : implications for cellular Ab metabolism .
8354270	0	HES-2	30,35	hairy	108,113	HES-2	hairy	54626	38995(Tax:7227)	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of HES-2 , a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split .
18499474	0	HES1	0,4	5-HT1A_receptor	15,30	HES1	5-HT1A receptor	3280	3350	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	HES1 regulates 5-HT1A_receptor gene transcription at a functional polymorphism : essential role in developmental expression .
24684754	0	HES1	54,58	notch	68,73	HES1	notch	3280	31293(Tax:7227)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Prostate_tumor_OVerexpressed-1 -LRB- PTOV1 -RRB- down-regulates HES1 and HEY1 notch targets genes and promotes prostate_cancer progression .
16753023	0	HES1	0,4	pRb	21,24	HES1	pRb	3280	5925	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	HES1 cooperates with pRb to activate RUNX2-dependent transcription .
26342546	0	HES5	0,4	STAT3	68,73	HES5	STAT3	388585	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival_in_hepatocellular_carcinoma .
17931718	0	HESX1	65,70	DNMT1	0,5	HESX1	DNMT1	15209(Tax:10090)	13433(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DNMT1 interacts with the developmental transcriptional repressor HESX1 .
20181723	0	HESX1	41,46	TLE1	13,17	HESX1	TLE1	15209(Tax:10090)	21885(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Corepressors TLE1 and TLE3 interact with HESX1 and PROP1 .
8081943	0	HEXA	27,31	Pst	2,5	HEXA	Pst	3073	7903	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	A Pst + polymorphism in the HEXA gene with an unusual geographic distribution .
2147427	0	HEXB	30,34	beta-hexosaminidase	75,94	HEXB	beta-hexosaminidase	3074	10724	Gene	Gene	gene|compound|START_ENTITY initiation|nmod|gene initiation|acl|encoding encoding|dobj|beta-subunit beta-subunit|nmod|END_ENTITY	Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase .
7918686	0	HEXB	52,56	beta-hexosaminidase	31,50	HEXB	beta-hexosaminidase	15212(Tax:10090)	76055(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the murine beta-hexosaminidase -LRB- HEXB -RRB- gene .
20201073	0	HEXIM1	153,159	Brd4_and_7SK	140,152	HEXIM1	Brd4 and 7SK	10614	23476	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4_and_7SK / HEXIM1 regulatory complexes .
18371977	0	HEXIM1	29,35	Nucleophosmin	0,13	HEXIM1	Nucleophosmin	10614	4869	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription .
18757415	0	HEXIM1	0,6	cyclin_D1	81,90	HEXIM1	cyclin D1	10614	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	HEXIM1 regulates 17beta-estradiol/estrogen _ receptor-alpha-mediated expression of cyclin_D1 in mammary cells via modulation of P-TEFb .
15941832	0	HEXIM1	0,6	glucocorticoid_receptor	55,78	HEXIM1	glucocorticoid receptor	10614	2908	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	HEXIM1 forms a transcriptionally abortive complex with glucocorticoid_receptor without involving 7SK RNA and positive transcription elongation factor b .
25301555	0	HEXIM1	94,100	hypoxia-inducible_factor-1_alpha	19,51	HEXIM1	hypoxia-inducible factor-1 alpha	192231(Tax:10090)	3091	Gene	Gene	attenuates|nummod|START_ENTITY END_ENTITY|nmod|attenuates	Down-regulation of hypoxia-inducible_factor-1_alpha and vascular_endothelial_growth_factor by HEXIM1 attenuates myocardial_angiogenesis in hypoxic mice .
747188	0	HEX_A	46,51	hexosaminidase_A	28,44	HEX A	hexosaminidase A	3073	3073	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of unusual hexosaminidase_A -LRB- HEX_A -RRB- deficient human mutants .
21454491	0	HEYL	44,48	androgen_receptor	14,31	HEYL	androgen receptor	26508	367	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Repression of androgen_receptor activity by HEYL , a third member of the Hairy/Enhancer-of-split - related family of Notch effectors .
24904118	0	HFE	0,3	ALK3	43,47	HFE	ALK3	3077	657	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression .
15880641	0	HFE	81,84	DMT1	124,128	HFE	DMT1	3077	4891	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Transferrin receptor co-localizes and interacts with the hemochromatosis factor -LRB- HFE -RRB- and the divalent_metal_transporter-1 -LRB- DMT1 -RRB- in trophoblast cells .
18521456	0	HFE	22,25	Hemochromatosis	0,15	HFE	Hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hemochromatosis gene -LRB- HFE -RRB- mutations in patients with type 2 diabetes and their control group in an Iranian population .
16043695	0	HFE	53,56	Nef	6,9	HFE	Nef	3077	6285	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	HIV-1 Nef down-regulates the hemochromatosis protein HFE , manipulating cellular iron homeostasis .
10318901	0	HFE	76,79	Transferrin_receptor	0,20	HFE	Transferrin receptor	3077	7037	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	Transferrin_receptor is negatively modulated by the hemochromatosis protein HFE : implications for cellular iron homeostasis .
12364722	0	HFE	39,42	hemochromatosis	17,32	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the hemochromatosis gene -LRB- HFE -RRB- and stroke .
12902032	0	HFE	39,42	hemochromatosis	17,32	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the hemochromatosis gene -LRB- HFE -RRB- , Parkinson 's _ disease and parkinsonism .
15017658	0	HFE	70,73	hemochromatosis	48,63	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Natural history of the C282Y homozygote for the hemochromatosis gene -LRB- HFE -RRB- with a normal serum ferritin level .
15955425	0	HFE	39,42	hemochromatosis	17,32	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the hemochromatosis gene -LRB- HFE -RRB- and multiple_sclerosis .
17013646	0	HFE	39,42	hemochromatosis	17,32	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequency of the hemochromatosis gene -LRB- HFE -RRB- 282C -- > Y , 63H -- > D , and 65S -- > C mutations in a general Mediterranean population from Tarragona , Spain .
19822954	0	HFE	39,42	hemochromatosis	17,32	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequency of the hemochromatosis gene -LRB- HFE -RRB- variants in a Jordanian Arab population and in diabetics from the same region .
8304342	0	HFE	122,125	hemochromatosis	100,115	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene -LRB- HFE -RRB- The hemochromatosis gene -LRB- HFE -RRB- maps to 6p21 .3 and is less than 1 cM from the HLA class I genes ; however , the precise physical location of the gene has remained elusive and controversial .
9789968	0	HFE	27,30	hemochromatosis	5,20	HFE	hemochromatosis	3077	3077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The hemochromatosis gene -LRB- HFE -RRB- .
10556042	0	HFE	28,31	transferrin	46,57	HFE	transferrin	3077	7018	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	The hemochromatosis protein HFE competes with transferrin for binding to the transferrin_receptor .
10572108	0	HFE	0,3	transferrin	35,46	HFE	transferrin	3077	7018	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|END_ENTITY	HFE downregulates iron uptake from transferrin and induces iron-regulatory protein activity in stably transfected cells .
10369785	0	HFE	41,44	transferrin_receptor	4,24	HFE	transferrin receptor	3077	7037	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	The transferrin_receptor binding site on HFE , the class I MHC-related protein mutated in hereditary_hemochromatosis .
10638746	0	HFE	61,64	transferrin_receptor	80,100	HFE	transferrin receptor	3077	7037	Gene	Gene	structure|nmod|START_ENTITY complexed|nsubj|structure complexed|nmod|END_ENTITY	Crystal structure of the hereditary_haemochromatosis protein HFE complexed with transferrin_receptor .
9546397	0	HFE	49,52	transferrin_receptor	98,118	HFE	transferrin receptor	3077	7037	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin_receptor .
18353247	0	HFE	0,3	transferrin_receptor_2	21,43	HFE	transferrin receptor 2	100762132	100752766	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	HFE association with transferrin_receptor_2 increases cellular uptake of transferrin-bound iron .
11060460	0	HFH-4	45,50	FOXJ1	32,37	HFH-4	FOXJ1	2302	2302	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No deleterious mutations in the FOXJ1 -LRB- alias HFH-4 -RRB- gene in patients with primary ciliary_dyskinesia -LRB- PCD -RRB- .
17286053	0	HFM1	0,4	Mer3	35,39	HFM1	Mer3	164045	852641(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	HFM1 , the human homologue of yeast Mer3 , encodes a putative DNA helicase expressed specifically in germ-line cells .
23224238	0	HFR1	60,64	KIDARI	32,38	HFR1	KIDARI	839300(Tax:3702)	839585(Tax:3702)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	A competitive peptide inhibitor KIDARI negatively regulates HFR1 by forming nonfunctional heterodimers in Arabidopsis photomorphogenesis .
24179122	0	HFR1	0,4	PIF1	16,20	HFR1	PIF1	839300(Tax:3702)	816538(Tax:3702)	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	HFR1 sequesters PIF1 to govern the transcriptional network underlying light-initiated seed germination in Arabidopsis .
16954503	0	HGAL	61,65	human_germinal_center-associated_lymphoma	18,59	HGAL	human germinal center-associated lymphoma	257144	257144	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of the human_germinal_center-associated_lymphoma -LRB- HGAL -RRB- protein identifies a subset of classic Hodgkin_lymphoma of germinal center derivation and improved survival .
22096245	0	HGAL	18,22	miR-155	0,7	HGAL	miR-155	257144	406947	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-155 regulates HGAL expression and increases lymphoma_cell_motility .
15452053	0	HGF	0,3	Akt-1	66,71	HGF	Akt-1	3082	207	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|nmod|END_ENTITY	HGF protects corneal epithelial cells from apoptosis by the PI-3K / Akt-1 / Bad - but not the ERK1/2-mediated signaling pathway .
22085542	0	HGF	62,65	Arf6	76,80	HGF	Arf6	403441(Tax:9615)	490679(Tax:9615)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration .
25539852	0	HGF	14,17	Asef	0,4	HGF	Asef	15234(Tax:10090)	226970(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|compound|END_ENTITY	Asef mediates HGF protective effects against LPS-induced lung_injury and endothelial barrier_dysfunction .
16840440	0	HGF	0,3	CXCR4	12,17	HGF	CXCR4	3082	7852	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|invasion invasion|compound|END_ENTITY	HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB .
20157762	0	HGF	0,3	CXCR4	16,21	HGF	CXCR4	3082	7852	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	HGF upregulates CXCR4 expression in gliomas via NF-kappaB : implications for glioma cell migration .
16840440	0	HGF	0,3	Ets1	61,65	HGF	Ets1	3082	2113	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB .
10521801	0	HGF	0,3	FAK	12,15	HGF	FAK	15234(Tax:10090)	14083(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast_carcinoma cells .
24517345	0	HGF	42,45	Glypican-1	0,10	HGF	Glypican-1	15234(Tax:10090)	14733(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Glypican-1 regulates myoblast response to HGF via Met in a lipid raft-dependent mechanism : effect on migration of skeletal muscle precursor cells .
25610321	0	HGF	46,49	Hepatocyte_Growth_Factor	20,44	HGF	Hepatocyte Growth Factor	3082	3082	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association between Hepatocyte_Growth_Factor -LRB- HGF -RRB- Gene Polymorphisms and Serum HGF Levels in Patients with Rheumatoid_Arthritis .
11164712	0	HGF	26,29	Hepatocyte_growth_factor	0,24	HGF	Hepatocyte growth factor	3082	3082	Gene	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation .
12201209	0	HGF	60,63	Hepatocyte_growth_factor	0,24	HGF	Hepatocyte growth factor	3082	3082	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Hepatocyte_growth_factor as cardiovascular hormone : role of HGF in the pathogenesis of cardiovascular_disease .
12613501	0	HGF	26,29	Hepatocyte_growth_factor	0,24	HGF	Hepatocyte growth factor	3082	3082	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- system in gingiva : HGF_activator expression by gingival epithelial cells .
12500176	0	HGF	0,3	IL-1beta	42,50	HGF	IL-1beta	100316908(Tax:9986)	100008990(Tax:9986)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	HGF regulation of RPE proliferation in an IL-1beta / retinal hole-induced rabbit model of PVR .
20726333	0	HGF	26,29	IL-1beta	207,215	HGF	IL-1beta	3082	3553	Gene	Gene	Hepatocyte_growth_factor|appos|START_ENTITY heat_shock|nsubj|Hepatocyte_growth_factor heat_shock|nmod|incubation incubation|nmod|camptothecin camptothecin|compound|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- , heat_shock proteins -LRB- HSPs -RRB- and multidrug resistance protein -LRB- MRP -RRB- expression in co-culture of colon_tumor spheroids with normal cells after incubation with interleukin-1beta -LRB- IL-1beta -RRB- and/or camptothecin -LRB- CPT-11 -RRB- .
20072693	0	HGF	20,23	IL-6	25,29	HGF	IL-6	3082	3569	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
3279116	1	HGF	168,171	IL-6	175,179	HGF	IL-6	3569	3569	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of leukocyte-derived HGF as IL-6 .
20072693	0	HGF	20,23	IL-8	31,35	HGF	IL-8	3082	3576	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
18495274	0	HGF	58,61	N-cadherin	18,28	HGF	N-cadherin	15234(Tax:10090)	12558(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role of N-cadherin in hepatocyte_growth_factor -LRB- HGF -RRB- mediated improvement of the cardiac function of dilated_cardiomyopathy_mice .
23840657	0	HGF	0,3	PRP	46,49	HGF	PRP	15234(Tax:10090)	19131(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	HGF mediates the anti-inflammatory effects of PRP on injured tendons .
22763439	0	HGF	77,80	RAF	54,57	HGF	RAF	3082	22882	Gene	Gene	secretion|compound|START_ENTITY innate|nmod|secretion innate|nmod|inhibitors inhibitors|compound|END_ENTITY	Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion .
24434899	0	HGF	22,25	RAF	83,86	HGF	RAF	3082	22882	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors .
25490933	0	HGF	96,99	RAF	73,76	HGF	RAF	3082	22882	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Registered report : Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion .
23148778	0	HGF	0,3	Rac1	19,23	HGF	Rac1	3082	5879	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic_fibrosis mutant F508del-CFTR .
21703184	0	HGF	48,51	SOCS1	0,5	HGF	SOCS1	15234(Tax:10090)	12703(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY controls|advcl|regulating controls|nsubj|END_ENTITY	SOCS1 controls liver_regeneration by regulating HGF signaling in hepatocytes .
17967179	0	HGF	44,47	SRC	27,30	HGF	SRC	3082	6714	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A novel activating role of SRC and STAT3 on HGF transcription in human breast_cancer cells .
19515904	0	HGF	76,79	Sema3A	114,120	HGF	Sema3A	3082	10371	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Possible implication of satellite cells in regenerative motoneuritogenesis : HGF upregulates neural chemorepellent Sema3A during myogenic differentiation .
22718393	0	HGF	0,3	TGF-b1	32,38	HGF	TGF-b1	24446(Tax:10116)	59086(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	HGF regulates the activation of TGF-b1 in rat hepatocytes and hepatic stellate cells .
12163028	0	HGF	30,33	USF	23,26	HGF	USF	3082	7391	Gene	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	A critical function of USF in HGF gene regulation mediated by a multiconsensus region .
20072693	0	HGF	20,23	VEGF	14,18	HGF	VEGF	3082	7422	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|compound|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
9403566	0	HGF	98,101	angiotensin_II	8,22	HGF	angiotensin II	24446(Tax:10116)	24179(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of angiotensin_II in the regulation of a novel vascular modulator , hepatocyte_growth_factor -LRB- HGF -RRB- , in experimental hypertensive rats .
9740609	0	HGF	155,158	angiotensin_II	68,82	HGF	angiotensin II	24446(Tax:10116)	24179(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Negative regulation of local hepatocyte_growth_factor expression by angiotensin_II and transforming growth factor-beta in blood vessels : potential role of HGF in cardiovascular_disease .
24034993	0	HGF	138,141	c-Met	1,6	HGF	c-Met	3082	4233	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	-LSB- c-Met signaling pathway participating in the gefitinib resistance of different gene types of non-small_cell_lung_cancer cells induced by HGF in vitro -RSB- .
16407846	0	HGF	50,53	c-Src	31,36	HGF	c-Src	3082	6714	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	A novel activating function of c-Src and Stat3 on HGF transcription in mammary_carcinoma cells .
17214965	0	HGF	38,41	cMet	81,85	HGF	cMet	100316908(Tax:9986)	100126565(Tax:9986)	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|interaction interaction|nmod|END_ENTITY	A neutralizable epitope is induced on HGF upon its interaction with its receptor cMet .
19578789	0	HGF	51,54	heme_oxygenase-1	74,90	HGF	heme oxygenase-1	15234(Tax:10090)	15368(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of IL-6 and IL-10 balance by HGF via recruitment of heme_oxygenase-1 in macrophages for attenuation of liver_injury in a mouse model of endotoxemia .
11054808	0	HGF	39,42	hepatocyte_growth_factor	13,37	HGF	hepatocyte growth factor	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of hepatocyte_growth_factor -LRB- HGF -RRB- in rat microglial cells by prostaglandin_E -LRB- 2 -RRB- .
12573464	0	HGF	50,53	hepatocyte_growth_factor	24,48	HGF	hepatocyte growth factor	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Exogenous expression of hepatocyte_growth_factor -LRB- HGF -RRB- in rat striatum by naked plasmid DNA .
12784998	0	HGF	35,38	hepatocyte_growth_factor	9,33	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	Roles of hepatocyte_growth_factor -LRB- HGF -RRB- activator and HGF_activator inhibitor in the pericellular activation of HGF/scatter factor .
14647442	0	HGF	36,39	hepatocyte_growth_factor	10,34	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human hepatocyte_growth_factor -LRB- HGF -RRB- gene is transcriptionally activated by leukemia_inhibitory_factor through the Stat binding element .
14675313	0	HGF	14,17	hepatocyte_growth_factor	19,43	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Comparison of HGF -LRB- hepatocyte_growth_factor -RRB- levels of epithelial_ovarian_cancer cyst fluids with benign ovarian_cysts .
15042617	0	HGF	96,99	hepatocyte_growth_factor	70,94	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Enhanced invasion of hormone refractory_prostate_cancer cells through hepatocyte_growth_factor -LRB- HGF -RRB- induction of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
1531136	0	HGF	42,45	hepatocyte_growth_factor	16,40	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of hepatocyte_growth_factor -LRB- HGF -RRB- gene on human chromosome 7 .
16116166	0	HGF	62,65	hepatocyte_growth_factor	36,60	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Follicular dendritic cells catalyze hepatocyte_growth_factor -LRB- HGF -RRB- activation in the germinal center microenvironment by secreting the serine protease HGF_activator .
16723436	0	HGF	63,66	hepatocyte_growth_factor	37,61	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Family-based association analysis of hepatocyte_growth_factor -LRB- HGF -RRB- gene polymorphisms in high_myopia .
19347810	0	HGF	49,52	hepatocyte_growth_factor	23,47	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	Serum concentration of hepatocyte_growth_factor -LRB- HGF -RRB- in oral_squamous_cell_carcinoma before and after surgery .
21897747	0	HGF	45,48	hepatocyte_growth_factor	19,43	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association of hepatocyte_growth_factor -LRB- HGF -RRB- gene with primary angle_closure_glaucoma in the Nepalese population .
24142532	0	HGF	57,60	hepatocyte_growth_factor	31,55	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Clinical significance of serum hepatocyte_growth_factor -LRB- HGF -RRB- levels in hepatocellular_carcinoma .
7556648	0	HGF	52,55	hepatocyte_growth_factor	26,50	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Concomitant expression of hepatocyte_growth_factor -LRB- HGF -RRB- , HGF_activator and c-met genes in human glioma cells in vitro .
7590606	0	HGF	41,44	hepatocyte_growth_factor	15,39	HGF	hepatocyte growth factor	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of hepatocyte_growth_factor -LRB- HGF -RRB- in LEC rats at various phases of hepatitis and hepatoma -RSB- .
9223667	0	HGF	60,63	hepatocyte_growth_factor	34,58	HGF	hepatocyte growth factor	15234(Tax:10090)	15234(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the hepatocyte_growth_factor -LRB- HGF -RRB- gene by the Sp family of transcription factors .
9227267	0	HGF	31,34	hepatocyte_growth_factor	5,29	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Tear hepatocyte_growth_factor -LRB- HGF -RRB- availability increases markedly after excimer laser surface ablation .
9542659	0	HGF	38,41	hepatocyte_growth_factor	12,36	HGF	hepatocyte growth factor	15234(Tax:10090)	15234(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of hepatocyte_growth_factor -LRB- HGF -RRB- at progressive stages of metanephric development .
9804260	0	HGF	57,60	hepatocyte_growth_factor	31,55	HGF	hepatocyte growth factor	3082	3082	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Decreased maternal circulating hepatocyte_growth_factor -LRB- HGF -RRB- concentrations in pregnancies with small for gestational age infants .
9927158	0	HGF	62,65	hepatocyte_growth_factor	36,60	HGF	hepatocyte growth factor	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Hepatocyte-stimulated expression of hepatocyte_growth_factor -LRB- HGF -RRB- in cultured rat hepatic stellate cells .
17204543	0	HGF	107,110	p38	125,128	HGF	p38	3082	1432	Gene	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF : the roles of p38 , ERK , and JNK MAPK signaling .
15042617	0	HGF	96,99	urokinase-type_plasminogen_activator	114,150	HGF	urokinase-type plasminogen activator	3082	5328	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Enhanced invasion of hormone refractory_prostate_cancer cells through hepatocyte_growth_factor -LRB- HGF -RRB- induction of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
15713485	0	HGFA	107,111	hepatocyte_growth_factor	71,95	HGFA	hepatocyte growth factor	3083	3082	Gene	Gene	activator|appos|START_ENTITY activator|compound|END_ENTITY	Conformational lability in serine_protease active sites : structures of hepatocyte_growth_factor activator -LRB- HGFA -RRB- alone and with the inhibitory domain from HGFA inhibitor-1B .
16005141	0	HGFA	42,46	hepatocyte_growth_factor	6,30	HGFA	hepatocyte growth factor	3083	3082	Gene	Gene	activator|appos|START_ENTITY activator|compound|END_ENTITY	Serum hepatocyte_growth_factor activator -LRB- HGFA -RRB- in benign_prostatic_hyperplasia and prostate_cancer .
16106403	0	HGF_activator	44,57	hepatocyte_growth_factor_activator	8,42	HGF activator	hepatocyte growth factor activator	3083	3083	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of hepatocyte_growth_factor_activator -LRB- HGF_activator -RRB- in invasive growth of human glioblastoma cells in vivo .
12473536	0	HGF_receptor	59,71	Sp1	0,3	HGF receptor	Sp1	17295(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Sp1 and Sp3 transcription factors synergistically regulate HGF_receptor gene expression in kidney .
1196424	0	HGPRT	48,53	Hypoxanthine_guanine_phosphoribosyltransferase	0,46	HGPRT	Hypoxanthine guanine phosphoribosyltransferase	15452(Tax:10090)	15452(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Hypoxanthine_guanine_phosphoribosyltransferase -LRB- HGPRT -RRB- activity in hybrids derived from HGPRT + and HGPRT - mouse cells .
762946	0	HGPRTase	62,70	hypoxanthineguanine-phosphoribosyltransferase	15,60	HGPRTase	hypoxanthineguanine-phosphoribosyltransferase	3251	3251	Gene	Gene	Properties|appos|START_ENTITY Properties|nmod|END_ENTITY	-LSB- Properties of hypoxanthineguanine-phosphoribosyltransferase -LRB- HGPRTase -RRB- in a gout patient with partial deficiency of this enzyme -LRB- author 's transl -RRB- -RSB- .
18469204	0	HHEX	54,58	CDKAL1	60,66	HHEX	CDKAL1	3087	54901	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
19008344	0	HHEX	64,68	CDKAL1	47,53	HHEX	CDKAL1	3087	54901	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	HHEX	46,50	CDKAL1	52,58	HHEX	CDKAL1	3087	54901	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
22487833	0	HHEX	75,79	CDKAL1	58,64	HHEX	CDKAL1	3087	54901	Gene	Gene	genes|dep|START_ENTITY genes|nummod|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
20424228	0	HHEX	61,65	CDKN2A	67,73	HHEX	CDKN2A	3087	1029	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
18469204	0	HHEX	54,58	CDKN2A/B	68,76	HHEX	CDKN2A/B	3087	1029;1030	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20509872	0	HHEX	46,50	CDKN2A/B	60,68	HHEX	CDKN2A/B	3087	1029;1030	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19008344	0	HHEX	64,68	EXT2	70,74	HHEX	EXT2	3087	2132	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	HHEX	64,68	FTO	42,45	HHEX	FTO	3087	79068	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|compound|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	HHEX	46,50	FTO	79,82	HHEX	FTO	3087	79068	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19008344	0	HHEX	64,68	IGF2BP2	76,83	HHEX	IGF2BP2	3087	10644	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	HHEX	46,50	IGF2BP2	70,77	HHEX	IGF2BP2	3087	10644	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20424228	0	HHEX	61,65	KCNJ11	36,42	HHEX	KCNJ11	3087	3767	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	HHEX	61,65	PPARG	29,34	HHEX	PPARG	3087	5468	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
18469204	0	HHEX	54,58	SLC30A8	45,52	HHEX	SLC30A8	3087	169026	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
19008344	0	HHEX	64,68	SLC30A8	55,62	HHEX	SLC30A8	3087	169026	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20424228	0	HHEX	61,65	SLC30A8	52,59	HHEX	SLC30A8	3087	169026	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20509872	0	HHEX	46,50	SLC30A8	37,44	HHEX	SLC30A8	3087	169026	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|compound|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
22487833	0	HHEX	75,79	SLC30A8	66,73	HHEX	SLC30A8	3087	169026	Gene	Gene	genes|dep|START_ENTITY genes|nummod|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
20509872	0	HHEX	46,50	TCF2	84,88	HHEX	TCF2	3087	6928	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	HHEX	54,58	TCF7L2	37,43	HHEX	TCF7L2	3087	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20424228	0	HHEX	61,65	TCF7L2	44,50	HHEX	TCF7L2	3087	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
22487833	0	HHEX	75,79	TCF7L2	50,56	HHEX	TCF7L2	3087	6934	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
19561609	0	HHIP	37,41	SHH	17,20	HHIP	SHH	64399	6469	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling .
9636371	0	HHR23A	0,6	RAD23	56,61	HHR23A	RAD23	5886	856674(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	HHR23A , the human homologue of the yeast repair protein RAD23 , interacts specifically with Vpr protein and prevents cell cycle arrest but not the transcriptional effects of Vpr .
16105547	0	HHR23A	0,6	Rad23	52,57	HHR23A	Rad23	5886	856674(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	HHR23A , a human homolog of Saccharomyces_cerevisiae Rad23 , regulates xeroderma_pigmentosum_C protein and is required for nucleotide excision repair .
11259200	0	HHR23A	64,70	Vpr	51,54	HHR23A	Vpr	5886	155807(Tax:11676)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Interaction of human_immunodeficiency_virus_type_1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr .
8756644	0	HHR23B	0,6	XPC	42,45	HHR23B	XPC	5887	7508	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|protein protein|compound|END_ENTITY	HHR23B , a human Rad23 homolog , stimulates XPC protein in nucleotide excision repair in vitro .
9164480	0	HHR23B	24,30	XPC	0,3	HHR23B	XPC	5887	7508	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	XPC interacts with both HHR23B and HHR23A in vivo .
19582149	0	HIC	26,29	Human_I-mfa_domain_containing_protein	31,68	HIC	Human I-mfa domain containing protein	29969	29969	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The complex regulation of HIC -LRB- Human_I-mfa_domain_containing_protein -RRB- expression .
12944466	0	HIC	43,46	I-mfa	10,15	HIC	I-mfa	29969	4188	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The human I-mfa domain-containing protein , HIC , interacts with cyclin_T1 and modulates P-TEFb-dependent transcription .
16778972	0	HIC-5	15,20	ARA55	21,26	HIC-5	ARA55	7041	7041	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	-LSB- Expression of HIC-5 / ARA55 in colonrectal_cancer and its mechanisms of action -RSB- .
16269335	0	HIC1	17,21	SIRT1	41,46	HIC1	SIRT1	15248(Tax:10090)	93759(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses .
23712868	0	HIF-1	32,37	AGR2	0,4	HIF-1	AGR2	3091	10551	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	AGR2 expression is regulated by HIF-1 and contributes to growth and angiogenesis of glioblastoma .
26512116	0	HIF-1	0,5	CD47	16,20	HIF-1	CD47	3091	961	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	HIF-1 regulates CD47 expression in breast_cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells .
22941344	0	HIF-1	40,45	CX3CR1	18,24	HIF-1	CX3CR1	3091	1524	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Hypoxia increases CX3CR1 expression via HIF-1 and NF - kB in androgen-independent prostate_cancer cells .
10683440	0	HIF-1	44,49	ERK	0,3	HIF-1	ERK	3091	5594	Gene	Gene	activation|compound|START_ENTITY involvement|nmod|activation activation|dep|involvement activation|compound|END_ENTITY	ERK activation upon hypoxia : involvement in HIF-1 activation .
12447987	0	HIF-1	61,66	ERK	8,11	HIF-1	ERK	3091	5594	Gene	Gene	activation|nmod|START_ENTITY Role|nmod|activation Role|nmod|END_ENTITY	Role of ERK and calcium in the hypoxia-induced activation of HIF-1 .
21059928	0	HIF-1	96,101	ERK	111,114	HIF-1	ERK	3091	5594	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- via the ERK pathway after hyperthermia treatment .
24425001	0	HIF-1	14,19	ERRa	0,4	HIF-1	ERRa	3091	2101	Gene	Gene	augments|dobj|START_ENTITY augments|nsubj|END_ENTITY	ERRa augments HIF-1 signalling by directly interacting with HIF-1a in normoxic and hypoxic prostate_cancer cells .
23585570	0	HIF-1	68,73	HER2/neu	13,21	HIF-1	HER2/neu	3091	2064	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	The oncogene HER2/neu -LRB- ERBB2 -RRB- requires the hypoxia-inducible factor HIF-1 for mammary_tumor growth and anoikis resistance .
26061431	0	HIF-1	91,96	HIF-1a	55,61	HIF-1	HIF-1a	3091	3091	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1a and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol .
24924632	0	HIF-1	71,76	HK-2	141,145	HIF-1	HK-2	3091	3099	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Fatty_acid-bearing albumin but not fatty_acid-depleted albumin induces HIF-1 activation in human renal proximal tubular epithelial cell line HK-2 .
18844219	0	HIF-1	43,48	HSP70-2	32,39	HIF-1	HSP70-2	3091	3306	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia .
19335985	0	HIF-1	60,65	HSP70-2	36,43	HIF-1	HSP70-2	3091	3306	Gene	Gene	dependent|amod|START_ENTITY -RSB-|amod|dependent expression|nmod|-RSB- expression|compound|END_ENTITY	-LSB- Hypoxia induces heat_shock protein HSP70-2 expression in a HIF-1 dependent manner -RSB- .
21092233	0	HIF-1	12,17	MICA	35,39	HIF-1	MICA	3091	100507436	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation .
19726677	0	HIF-1	59,64	Mint3	0,5	HIF-1	Mint3	3091	9546	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Mint3 enhances the activity of hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- in macrophages by suppressing the activity of factor_inhibiting_HIF-1 .
23216940	0	HIF-1	90,95	Myeloid_cell_leukemia-1	0,23	HIF-1	Myeloid cell leukemia-1	3091	4170	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Myeloid_cell_leukemia-1 -LRB- Mc1-1 -RRB- is a candidate target gene of hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- in the testis .
18209490	0	HIF-1	15,20	NDRG2	0,5	HIF-1	NDRG2	3091	57447	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells .
15240510	0	HIF-1	55,60	NF-kappaB	35,44	HIF-1	NF-kappaB	3091	4790	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor-activated NF-kappaB regulates HIF-1 activity and ODC expression , implicated in survival , differently in different carcinoma cell lines .
9486205	0	HIF-1	86,91	NOS	24,27	HIF-1	NOS	3091	4843	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1 .
24928198	0	HIF-1	17,22	RLIP76	0,6	HIF-1	RLIP76	3091	10928	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	RLIP76 regulates HIF-1 activity , VEGF expression and secretion in tumor cells , and secretome transactivation of endothelial cells .
19165496	0	HIF-1	15,20	Rac1	0,4	HIF-1	Rac1	3091	5879	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Rac1 activates HIF-1 in retinal_pigment_epithelium cells under hypoxia .
22553600	0	HIF-1	15,20	Rac1	0,4	HIF-1	Rac1	3091	5879	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Rac1 activates HIF-1 in laser induced choroidal_neovascularization .
19524065	0	HIF-1	0,5	Ref-1	17,22	HIF-1	Ref-1	3091	328	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	HIF-1 attenuates Ref-1 expression in endothelial cells : reversal by siRNA and inhibition of geranylgeranylation .
15235597	0	HIF-1	70,75	SDF-1	89,94	HIF-1	SDF-1	3091	6387	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 .
19786016	0	HIF-1	21,26	Stanniocalcin-2	0,15	HIF-1	Stanniocalcin-2	3091	8614	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia .
22918951	0	HIF-1	25,30	TTP	44,47	HIF-1	TTP	3091	7538	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Multilevel regulation of HIF-1 signaling by TTP .
14715242	0	HIF-1	78,83	VEGF	40,44	HIF-1	VEGF	3091	7422	Gene	Gene	role|nmod|START_ENTITY effects|dep|role effects|nmod|prostaglandin-J2 prostaglandin-J2|nmod|END_ENTITY	Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia : role of HIF-1 .
15665520	0	HIF-1	78,83	VEGF	0,4	HIF-1	VEGF	3091	7422	Gene	Gene	signaling|amod|START_ENTITY requirement|nmod|signaling production|dep|requirement production|amod|END_ENTITY	VEGF production by primary human renal proximal tubular cells : requirement of HIF-1 , PI3-kinase and MAPKK-1 signaling .
17268888	0	HIF-1	29,34	VEGF	74,78	HIF-1	VEGF	3091	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	The hypoxia-inducible factor HIF-1 promotes intramyocardial expression of VEGF in infants with congenital cardiac_defects .
20423107	0	HIF-1	100,105	VEGF	106,110	HIF-1	VEGF	3091	7422	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1 / VEGF pathway .
23049945	0	HIF-1	74,79	VEGF	52,56	HIF-1	VEGF	3091	7422	Gene	Gene	independently|nmod|START_ENTITY independently|compound|END_ENTITY	Activation of protease-activated_receptor_2 induces VEGF independently of HIF-1 .
24347168	0	HIF-1	115,120	VEGF	199,203	HIF-1	VEGF	3091	7422	Gene	Gene	activity|compound|START_ENTITY activity|nmod|targets targets|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Endoplasmic reticulum -LRB- ER -RRB- stress and hypoxia response pathways interact to potentiate hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- transcriptional activity on targets like vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
26193287	0	HIF-1	84,89	VEGF	90,94	HIF-1	VEGF	3091	7422	Gene	Gene	Angiogenesis|nmod|START_ENTITY Angiogenesis|dep|Signaling Signaling|compound|END_ENTITY	Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1 / VEGF Signaling under Hypoxia .
17213816	0	HIF-1	14,19	YC-1	0,4	HIF-1	YC-1	3091	5937	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	YC-1 inhibits HIF-1 expression in prostate_cancer cells : contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia .
12507560	0	HIF-1	68,73	hypoxia-inducible_factor-1	40,66	HIF-1	hypoxia-inducible factor-1	3091	3091	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	The von_Hippel-Lindau_tumor suppressor , hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- degradation , and cancer pathogenesis .
17190448	0	HIF-1	131,136	hypoxia-inducible_factor-1	103,129	HIF-1	hypoxia-inducible factor-1	3091	3091	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Sodwanone and yardenone_triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- activation in both breast_and_prostate_tumor cells .
19091749	0	HIF-1	61,66	hypoxia-inducible_factor-1	33,59	HIF-1	hypoxia-inducible factor-1	3091	3091	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Methylalpinumisoflavone inhibits hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- activation by simultaneously targeting multiple pathways .
15901372	1	HIF-1	61,66	hypoxia-inducible_factor_1	33,59	HIF-1	hypoxia-inducible factor 1	3091	3091	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- by nitric_oxide in oral_squamous_cell_carcinoma .
24347168	0	HIF-1	115,120	hypoxia-inducible_factor_1	87,113	HIF-1	hypoxia-inducible factor 1	3091	3091	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Endoplasmic reticulum -LRB- ER -RRB- stress and hypoxia response pathways interact to potentiate hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- transcriptional activity on targets like vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
11532856	0	HIF-1	75,80	hypoxia_inducible_factor-1	47,73	HIF-1	hypoxia inducible factor-1	3091	3091	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Hepatocyte_growth_factor signalling stimulates hypoxia_inducible_factor-1 -LRB- HIF-1 -RRB- activity in HepG2 hepatoma cells .
15452150	0	HIF-1	40,45	hypoxia_inducible_factor_1	12,38	HIF-1	hypoxia inducible factor 1	3091	3091	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of hypoxia_inducible_factor_1 -LRB- HIF-1 -RRB- in hypoxia induced apoptosis .
9887100	0	HIF-1	87,92	p35srj	19,25	HIF-1	p35srj	3091	10370	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of p35srj , a novel p300/CBP binding protein , during transactivation by HIF-1 .
11375890	0	HIF-1	14,19	p53	80,83	HIF-1	p53	3091	7157	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Inhibition of HIF-1 - and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions .
22360728	0	HIF-1	53,58	prolyl_hydroxylase_2	62,82	HIF-1	prolyl hydroxylase 2	3091	54583	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of reactive oxygen species in the regulation of HIF-1 by prolyl_hydroxylase_2 under mild hypoxia .
16909104	0	HIF-1_alpha	75,86	CCK2_receptor	22,35	HIF-1 alpha	CCK2 receptor	3091	887	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Constitutively active CCK2_receptor splice variant increases Src-dependent HIF-1_alpha expression and tumor growth .
17507435	0	HIF-1_alpha	10,21	HIF-2_alpha	23,34	HIF-1 alpha	HIF-2 alpha	3091	2034	Gene	Gene	START_ENTITY|appos|proteins proteins|amod|END_ENTITY	Placental HIF-1_alpha , HIF-2_alpha , membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine_growth_restriction .
12646199	0	HIF-1_alpha	54,65	VEGF	94,98	HIF-1 alpha	VEGF	3091	7422	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Dibenzoylmethane , a natural dietary compound , induces HIF-1_alpha and increases expression of VEGF .
15135139	0	HIF-1_alpha	84,95	VEGF	14,18	HIF-1 alpha	VEGF	15251(Tax:10090)	22339(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|Expression Expression|nmod|isoforms isoforms|amod|END_ENTITY	Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1_alpha dependent .
15277511	0	HIF-1_alpha	67,78	VEGF	14,18	HIF-1 alpha	VEGF	3091	7422	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|END_ENTITY	IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1_alpha expression and activity in retinal pigment epithelial cell line D407 .
17947829	0	HIF-1_alpha	43,54	VEGF	14,18	HIF-1 alpha	VEGF	3091	7422	Gene	Gene	targeting|dobj|START_ENTITY expression|advcl|targeting expression|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of VEGF expression by targeting HIF-1_alpha with small interference RNA in human RPE cells .
20232316	0	HIF-1_alpha	47,58	VEGF	18,22	HIF-1 alpha	VEGF	3091	7422	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	miR-20b modulates VEGF expression by targeting HIF-1_alpha and STAT3 in MCF-7 breast_cancer cells .
17592963	0	HIF-1_alpha	0,11	galectin-3	30,40	HIF-1 alpha	galectin-3	15251(Tax:10090)	16854(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	HIF-1_alpha is a regulator of galectin-3 expression in the intervertebral disc .
22565593	0	HIF-1a	104,110	AKT	145,148	HIF-1a	AKT	3091	207	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	RY10-4 , a novel anti-tumor compound , exhibited its anti-angiogenesis activity by down-regulation of the HIF-1a and inhibition phosphorylation of AKT and mTOR .
25561311	0	HIF-1a	82,88	AKT	89,92	HIF-1a	AKT	3091	207	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Chlorogenic_acid inhibits hypoxia-induced angiogenesis via down-regulation of the HIF-1a / AKT pathway .
23791554	0	HIF-1a	36,42	AMPK	69,73	HIF-1a	AMPK	3091	5563	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Mitochondrial dysfunction represses HIF-1a protein synthesis through AMPK activation in human hepatoma HepG2 cells .
25695729	0	HIF-1a	13,19	Akt	137,140	HIF-1a	Akt	3091	207	Gene	Gene	expression|compound|START_ENTITY blocks|dobj|expression blocks|advcl|inhibit inhibit|advcl|downregulating downregulating|dobj|activation activation|nmod|END_ENTITY	SOCS3 blocks HIF-1a expression to inhibit proliferation and angiogenesis of human small_cell_lung_cancer by downregulating activation of Akt , but not STAT3 .
25385144	0	HIF-1a	58,64	Bcl-2	73,78	HIF-1a	Bcl-2	3091	596	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1a / miR-210 / Bcl-2 pathway in colon_cancer cells .
25967708	0	HIF-1a	54,60	CD25	25,29	HIF-1a	CD25	3091	3559	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|Treg Treg|compound|END_ENTITY	Relationship between CD4 + CD25 + Treg and expression of HIF-1a and Ki-67 in NSCLC patients .
25967708	0	HIF-1a	54,60	CD4	21,24	HIF-1a	CD4	3091	920	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|Treg Treg|compound|END_ENTITY	Relationship between CD4 + CD25 + Treg and expression of HIF-1a and Ki-67 in NSCLC patients .
26150319	0	HIF-1a	24,30	CD4	45,48	HIF-1a	CD4	3091	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Transcription regulates HIF-1a expression in CD4 -LRB- + -RRB- T cells .
22937154	0	HIF-1a	56,62	CD44	18,22	HIF-1a	CD44	3091	960	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Hypoxia regulates CD44 and its variant isoforms through HIF-1a in triple negative breast_cancer .
24189531	0	HIF-1a	16,22	CDK1	0,4	HIF-1a	CDK1	3091	983	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	CDK1 stabilizes HIF-1a via direct phosphorylation of Ser668 to promote tumor growth .
20869949	0	HIF-1a	74,80	CXCR4	33,38	HIF-1a	CXCR4	3091	7852	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|advcl|activating	Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1a in MSCs .
24618817	0	HIF-1a	60,66	CXCR4	39,44	HIF-1a	CXCR4	3091	7852	Gene	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|nummod|END_ENTITY	Hypoxia promotes migration and induces CXCR4 expression via HIF-1a activation in human osteosarcoma .
26521940	0	HIF-1a	39,45	CYP7A1	22,28	HIF-1a	CYP7A1	3091	1581	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|END_ENTITY	Hypoxic Repression of CYP7A1 through a HIF-1a - and SHP-Independent Mechanism .
23936001	0	HIF-1a	20,26	ERK	65,68	HIF-1a	ERK	3091	5594	Gene	Gene	START_ENTITY|parataxis|VEGF VEGF|nmod|inhibition inhibition|nmod|END_ENTITY	Melittin suppresses HIF-1a / VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical_carcinoma cells .
24627260	0	HIF-1a	16,22	ERK	41,44	HIF-1a	ERK	29560(Tax:10116)	24338(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Upregulation of HIF-1a via activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial_injury in neuron-like cells .
24323731	0	HIF-1a	24,30	Erythropoietin	0,14	HIF-1a	Erythropoietin	29560(Tax:10116)	24335(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Erythropoietin inhibits HIF-1a expression via upregulation of PHD-2 transcription and translation in an in vitro model of hypoxia-ischemia .
21732131	0	HIF-1a	79,85	FIH-1	12,17	HIF-1a	FIH-1	3091	55662	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Subcellular FIH-1 expression patterns in invasive breast_cancer in relation to HIF-1a expression .
23628900	0	HIF-1a	92,98	Fhl-1	99,104	HIF-1a	Fhl-1	3091	2273	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	MicroRNA-206 is involved in hypoxia-induced pulmonary_hypertension through targeting of the HIF-1a / Fhl-1 pathway .
23475391	0	HIF-1a	38,44	Geranylgeranyltransferase_I	0,27	HIF-1a	Geranylgeranyltransferase I	3091	5229	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Geranylgeranyltransferase_I regulates HIF-1a promoting glioblastoma cell migration and invasion .
26765925	0	HIF-1a	122,128	HDAC6	86,91	HIF-1a	HDAC6	3091	10013	Gene	Gene	Activity|compound|START_ENTITY Promotes|dobj|Activity Promotes|nsubj|END_ENTITY	Class I and IIa HDACs Mediate HIF-1a Stability through PHD2-Dependent Mechanism while HDAC6 , a Class IIb Member , Promotes HIF-1a Transcriptional Activity in Nucleus Pulposus Cells of the Intervertebral Disc .
26061431	0	HIF-1a	55,61	HIF-1	91,96	HIF-1a	HIF-1	3091	3091	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1a and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol .
23594994	0	HIF-1a	62,68	Hypoxia-Inducible_Factor_1a	33,60	HIF-1a	Hypoxia-Inducible Factor 1a	3091	3091	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	MiR199b Suppresses Expression of Hypoxia-Inducible_Factor_1a -LRB- HIF-1a -RRB- in Prostate_Cancer Cells .
24803010	0	HIF-1a	29,35	Hypoxia-inducible_factor-1a	0,27	HIF-1a	Hypoxia-inducible factor-1a	3091	3091	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression in placentae of women with iron_deficiency_anemia_and_b-thalassemia trait .
25833522	0	HIF-1a	48,54	Hypoxia_Inducible_Factor-1alpha	15,46	HIF-1a	Hypoxia Inducible Factor-1alpha	3091	3091	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	The Changes by Hypoxia_Inducible_Factor-1alpha -LRB- HIF-1a -RRB- on Taurine Uptake in Brain Capillary Endothelial Cells at High Glucose Conditions .
22249478	0	HIF-1a	43,49	IL-1_b	81,87	HIF-1a	IL-1 b	3091	3553	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
22977270	0	HIF-1a	35,41	ISCU	55,59	HIF-1a	ISCU	3091	27247	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a signaling axis HIF-1a / microRNA-210 / ISCU independent of SDH mutation that defines a subgroup of head and neck_paragangliomas .
25655308	0	HIF-1a	66,72	LB-1	0,4	HIF-1a	LB-1	3091	26586	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	LB-1 Exerts Antitumor Activity in Pancreatic_Cancer by Inhibiting HIF-1a and Stat3 Signaling .
21460102	0	HIF-1a	68,74	MAT2A	111,116	HIF-1a	MAT2A	3091	4144	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Hypoxia induces genomic DNA demethylation through the activation of HIF-1a and transcriptional upregulation of MAT2A in hepatoma cells .
21738685	0	HIF-1a	12,18	MT1-MMP	19,26	HIF-1a	MT1-MMP	3091	4323	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|axis axis|compound|END_ENTITY	A concerted HIF-1a / MT1-MMP signalling axis regulates the expression of the 3BP2 adaptor protein in hypoxic mesenchymal stromal cells .
25053591	0	HIF-1a	99,105	Melittin	0,8	HIF-1a	Melittin	3091	406130(Tax:7460)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Melittin enhances radiosensitivity of hypoxic head_and_neck_squamous_cell_carcinoma by suppressing HIF-1a .
23594994	0	HIF-1a	62,68	MiR199b	0,7	HIF-1a	MiR199b	3091	406978	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	MiR199b Suppresses Expression of Hypoxia-Inducible_Factor_1a -LRB- HIF-1a -RRB- in Prostate_Cancer Cells .
23526365	0	HIF-1a	0,6	NDRG1	20,25	HIF-1a	NDRG1	3091	10397	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	HIF-1a up-regulates NDRG1 expression through binding to NDRG1 promoter , leading to proliferation of lung_cancer A549 cells .
22100406	0	HIF-1a	51,57	NDUFA4L2	31,39	HIF-1a	NDUFA4L2	15251(Tax:10090)	407790(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Induction of the mitochondrial NDUFA4L2 protein by HIF-1a decreases oxygen consumption by inhibiting Complex I activity .
24778419	0	HIF-1a	34,40	PD-L1	0,5	HIF-1a	PD-L1	15251(Tax:10090)	60533(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	PD-L1 is a novel direct target of HIF-1a , and its blockade under hypoxia enhanced MDSC-mediated T cell activation .
26697750	0	HIF-1a	47,53	PIAS3	0,5	HIF-1a	PIAS3	3091	10401	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	PIAS3 enhances the transcriptional activity of HIF-1a by increasing its protein stability .
26739387	0	HIF-1a	47,53	PKM2	0,4	HIF-1a	PKM2	3091	5315	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	PKM2 promotes tumor angiogenesis by regulating HIF-1a through NF-kB activation .
23395615	0	HIF-1a	48,54	Prox1	34,39	HIF-1a	Prox1	3091	5629	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of the Prox1 gene by HIF-1a and HIF-2a in response to hypoxia .
21514280	0	HIF-1a	56,62	RANK	16,20	HIF-1a	RANK	3091	8792	Gene	Gene	activating|dobj|START_ENTITY induces|advcl|activating induces|dobj|expression expression|compound|END_ENTITY	Hypoxia induces RANK and RANKL expression by activating HIF-1a in breast_cancer cells .
24845641	0	HIF-1a	84,90	SDF-1	91,96	HIF-1a	SDF-1	15251(Tax:10090)	20315(Tax:10090)	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	PPARa regulates mobilization and homing of endothelial progenitor cells through the HIF-1a / SDF-1 pathway .
27044634	0	HIF-1a	53,59	SNAIL	0,5	HIF-1a	SNAIL	3091	6615	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|gene gene|compound|END_ENTITY	SNAIL gene inhibited by hypoxia-inducible_factor_1a -LRB- HIF-1a -RRB- in epithelial_ovarian_cancer .
23131565	0	HIF-1a	92,98	SP1	50,53	HIF-1a	SP1	3091	6667	Gene	Gene	hypoxia-inducible_factor_1_alpha|appos|START_ENTITY specific_protein_1|nmod|hypoxia-inducible_factor_1_alpha specific_protein_1|appos|END_ENTITY	Transcriptional regulation of specific_protein_1 -LRB- SP1 -RRB- by hypoxia-inducible_factor_1_alpha -LRB- HIF-1a -RRB- leads to PRNP expression and neuroprotection from toxic prion peptide .
25572001	0	HIF-1a	95,101	Siah1	17,22	HIF-1a	Siah1	3091	6477	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Ubiquitin ligase Siah1 promotes the migration and invasion of human glioma cells by regulating HIF-1a signaling under hypoxia .
21335603	0	HIF-1a	14,20	Src	0,3	HIF-1a	Src	3091	6714	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Src activates HIF-1a not through direct phosphorylation of HIF-1a specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway .
24335623	0	HIF-1a	75,81	TFAP2A	0,6	HIF-1a	TFAP2A	3091	7020	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	TFAP2A regulates nasopharyngeal_carcinoma growth and survival by targeting HIF-1a signaling pathway .
23185615	0	HIF-1a	96,102	TLR4	67,71	HIF-1a	TLR4	15251(Tax:10090)	21898(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Peroxiredoxin_1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1a .
22320863	0	HIF-1a	0,6	TNF-a	26,31	HIF-1a	TNF-a	3091	7124	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	HIF-1a acts downstream of TNF-a to inhibit vasodilator-stimulated_phosphoprotein expression and modulates the adhesion and proliferation of breast_cancer cells .
25051011	0	HIF-1a	27,33	TNF-a	0,5	HIF-1a	TNF-a	3091	7124	Gene	Gene	increase|nmod|START_ENTITY increase|amod|END_ENTITY	TNF-a mediated increase of HIF-1a inhibits VASP expression , which reduces alveolar-capillary barrier function during acute_lung_injury -LRB- ALI -RRB- .
26741705	0	HIF-1a	11,17	TNF-a	42,47	HIF-1a	TNF-a	29560(Tax:10116)	24835(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Inhibiting HIF-1a Decreases Expression of TNF-a and Caspase-3 in Specific Brain Regions Exposed Kainic_Acid-Induced Status_Epilepticus .
23722539	0	HIF-1a	32,38	TRAF6	0,5	HIF-1a	TRAF6	3091	7189	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TRAF6 upregulates expression of HIF-1a and promotes tumor angiogenesis .
23185316	0	HIF-1a	49,55	Tissue_transglutaminase	0,23	HIF-1a	Tissue transglutaminase	3091	7052	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Tissue_transglutaminase constitutively activates HIF-1a promoter and nuclear factor-kB via a non-canonical pathway .
23185316	0	HIF-1a	49,55	Tissue_transglutaminase	0,23	HIF-1a	Tissue transglutaminase	3091	7052	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Tissue_transglutaminase constitutively activates HIF-1a promoter and nuclear factor-kB via a non-canonical pathway .
22128162	0	HIF-1a	78,84	Ubiquitin-specific_protease_19	0,30	HIF-1a	Ubiquitin-specific protease 19	3091	10869	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Ubiquitin-specific_protease_19 -LRB- USP19 -RRB- regulates hypoxia-inducible_factor_1a -LRB- HIF-1a -RRB- during hypoxia .
25548487	0	HIF-1a	0,6	VE-cadherin	15,26	HIF-1a	VE-cadherin	15251(Tax:10090)	12562(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	HIF-1a induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal_carcinoma cells .
20827786	0	HIF-1a	0,6	VEGF	61,65	HIF-1a	VEGF	15251(Tax:10090)	22339(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY ameliorates|nsubj|inhibition ameliorates|dobj|allergic_airway_disease allergic_airway_disease|nmod|suppression suppression|compound|END_ENTITY	HIF-1a inhibition ameliorates an allergic_airway_disease via VEGF suppression in bronchial epithelium .
21479433	0	HIF-1a	50,56	VEGF	32,36	HIF-1a	VEGF	3091	7422	Gene	Gene	degradation|compound|START_ENTITY secretion|nmod|degradation secretion|nsubj|reduction reduction|nmod|END_ENTITY	Zebularine-induced reduction in VEGF secretion by HIF-1a degradation in oral_squamous_cell_carcinoma .
22004076	0	HIF-1a	41,47	VEGF	22,26	HIF-1a	VEGF	3091	7422	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	A novel regulation of VEGF expression by HIF-1a and STAT3 in HDM2 transfected prostate_cancer cells .
22300081	0	HIF-1a	33,39	VEGF	43,47	HIF-1a	VEGF	3091	7422	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Critical role of hypoxia sensor -- HIF-1a in VEGF gene activation .
22511848	0	HIF-1a	80,86	VEGF	14,18	HIF-1a	VEGF	15251(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of VEGF expression and corneal_neovascularization by shRNA targeting HIF-1a in a mouse model of closed eye contact_lens wear .
22546754	0	HIF-1a	0,6	VEGF	7,11	HIF-1a	VEGF	3091	7422	Gene	Gene	START_ENTITY|parataxis|play play|nsubj|signaling signaling|compound|END_ENTITY	HIF-1a / VEGF signaling pathway may play a dual role in secondary pathogenesis of cervical myelopathy .
22649212	0	HIF-1a	88,94	VEGF	95,99	HIF-1a	VEGF	3091	7422	Gene	Gene	suppression|nmod|START_ENTITY survival|nmod|suppression miR-23b|nmod|survival END_ENTITY|amod|miR-23b	VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1a / VEGF and b-catenin/Tcf -4 signaling .
22771629	0	HIF-1a	46,52	VEGF	62,66	HIF-1a	VEGF	3091	7422	Gene	Gene	mediated|amod|START_ENTITY secretion|amod|mediated secretion|compound|END_ENTITY	Notoginsenoside_Ft1 promotes angiogenesis via HIF-1a mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways .
22932708	0	HIF-1a	69,75	VEGF	81,85	HIF-1a	VEGF	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	activating|dobj|START_ENTITY effect|acl|activating exerts|dobj|effect HO-1|dep|exerts HO-1|appos|signaling signaling|nsubj|END_ENTITY	M3-mAChR stimulation exerts anti-apoptotic effect via activating the HIF-1a / HO-1 / VEGF signaling pathway in H9c2 rat ventricular cells .
22970342	0	HIF-1a	33,39	VEGF	14,18	HIF-1a	VEGF	396696(Tax:9823)	397157(Tax:9823)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of VEGF expression by HIF-1a in the femoral_head_cartilage following ischemia_osteonecrosis .
23096096	0	HIF-1a	67,73	VEGF	16,20	HIF-1a	VEGF	3091	7422	Gene	Gene	accumulation|nmod|START_ENTITY associated|nmod|accumulation associated|nsubjpass|Upregulation Upregulation|nmod|expression expression|compound|END_ENTITY	Upregulation of VEGF expression is associated with accumulation of HIF-1a in the skin of na ve scleroderma patients .
23185615	0	HIF-1a	96,102	VEGF	58,62	HIF-1a	VEGF	15251(Tax:10090)	22339(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Peroxiredoxin_1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1a .
23279259	0	HIF-1a	30,36	VEGF	24,28	HIF-1a	VEGF	3091	7422	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Microvessel density and VEGF , HIF-1a expression in primary oral_melanoma : correlation with prognosis .
23326384	0	HIF-1a	6,12	VEGF	0,4	HIF-1a	VEGF	3091	7422	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	VEGF , HIF-1a expression and MVD as an angiogenic network in familial breast_cancer .
23416116	0	HIF-1a	67,73	VEGF	74,78	HIF-1a	VEGF	3091	7422	Gene	Gene	angiogenesis|nmod|START_ENTITY angiogenesis|parataxis|signaling signaling|nsubj|END_ENTITY	Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1a / VEGF signaling pathway in human bladder_cancer cells .
23791618	0	HIF-1a	133,139	VEGF	140,144	HIF-1a	VEGF	3091	7422	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The radiosensitizing effect of CpG ODN107 on human glioma cells is tightly related to its antiangiogenic activity via suppression of HIF-1a / VEGF pathway .
23869238	0	HIF-1a	43,49	VEGF	50,54	HIF-1a	VEGF	3091	7422	Gene	Gene	NF-kB/COX|nummod|START_ENTITY hTERT|appos|NF-kB/COX hTERT|dep|Signaling Signaling|compound|END_ENTITY	Berberine Targets AP-2 / hTERT , NF-kB/COX -2 , HIF-1a / VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth .
23947803	0	HIF-1a	0,6	VEGF	49,53	HIF-1a	VEGF	3091	7422	Gene	Gene	START_ENTITY|parataxis|mediates mediates|dobj|expression expression|nmod|END_ENTITY	HIF-1a / GPER signaling mediates the expression of VEGF induced by hypoxia in breast_cancer associated fibroblasts -LRB- CAFs -RRB- .
24098549	0	HIF-1a	65,71	VEGF	41,45	HIF-1a	VEGF	15251(Tax:10090)	22339(Tax:10090)	Gene	Gene	stimulate|nmod|START_ENTITY stimulate|dobj|expression expression|amod|END_ENTITY	Fumaric_acid_esters stimulate astrocytic VEGF expression through HIF-1a and Nrf2 .
25405167	0	HIF-1a	0,6	VEGF	75,79	HIF-1a	VEGF	3091	7422	Gene	Gene	regulated|nsubj|START_ENTITY regulated|dobj|growth growth|acl|regulating regulating|dobj|expression expression|amod|END_ENTITY	HIF-1a regulated tongue_squamous_cell_carcinoma cell growth via regulating VEGF expression in a xenograft model .
25945035	0	HIF-1a	67,73	VEGF	74,78	HIF-1a	VEGF	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	Promoting|nmod|START_ENTITY stimulates|dep|Promoting stimulates|amod|END_ENTITY	Promoting endothelial function by S-nitrosoglutathione through the HIF-1a / VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats .
25945035	0	HIF-1a	67,73	VEGF	74,78	HIF-1a	VEGF	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	Promoting|nmod|START_ENTITY stimulates|dep|Promoting stimulates|amod|END_ENTITY	Promoting endothelial function by S-nitrosoglutathione through the HIF-1a / VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats .
25955241	0	HIF-1a	59,65	VEGF	31,35	HIF-1a	VEGF	3091	7422	Gene	Gene	pathways|amod|START_ENTITY inhibits|nmod|pathways inhibits|dobj|expression expression|amod|END_ENTITY	3,3 ' - Diindolylmethane inhibits VEGF expression through the HIF-1a and NF-kB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions .
26345811	0	HIF-1a	10,16	VEGF	17,21	HIF-1a	VEGF	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|parataxis|signaling signaling|nsubj|END_ENTITY	Effect of HIF-1a / VEGF signaling pathway on plasma progesterone and ovarian prostaglandin_F2a secretion during luteal development of pseudopregnant rats .
26345811	0	HIF-1a	10,16	VEGF	17,21	HIF-1a	VEGF	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|parataxis|signaling signaling|nsubj|END_ENTITY	Effect of HIF-1a / VEGF signaling pathway on plasma progesterone and ovarian prostaglandin_F2a secretion during luteal development of pseudopregnant rats .
26537366	0	HIF-1a	27,33	VEGF	34,38	HIF-1a	VEGF	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	coupled|nmod|START_ENTITY Wnt/b-catenin|acl|coupled Wnt/b-catenin|parataxis|signaling signaling|nsubj|END_ENTITY	Wnt/b-catenin coupled with HIF-1a / VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral_ischemia .
26882120	0	HIF-1a	25,31	VEGF	129,133	HIF-1a	VEGF	3091	7422	Gene	Gene	ENO1|nmod|START_ENTITY Up-Regulation|nmod|ENO1 Involved|nsubjpass|Up-Regulation Involved|nmod|Regulation Regulation|nmod|Secretion Secretion|compound|END_ENTITY	Up-Regulation of ENO1 by HIF-1a in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion .
26942921	0	HIF-1a	77,83	VEGF	84,88	HIF-1a	VEGF	3091	7422	Gene	Gene	signals|amod|START_ENTITY signals|compound|END_ENTITY	Valproic_acid inhibits the angiogenic potential of cervical_cancer cells via HIF-1a / VEGF signals .
26987747	0	HIF-1a	17,23	VEGF	34,38	HIF-1a	VEGF	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	Stabilization|nmod|START_ENTITY modulates|nsubj|Stabilization modulates|xcomp|END_ENTITY	Stabilization of HIF-1a modulates VEGF and caspase-3 in hippocampus of rats following transient global ischemia induced by asphyxial cardiac_arrest .
24611881	0	HIF-1a	21,27	VEGFA	28,33	HIF-1a	VEGFA	3091	7422	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Sorafenib blocks the HIF-1a / VEGFA pathway , inhibits tumor invasion , and induces apoptosis in hepatoma cells .
23874890	0	HIF-1a	80,86	cofilin	90,97	HIF-1a	cofilin	3091	1072	Gene	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Hypoxia modulates fibroblastic architecture , adhesion and migration : a role for HIF-1a in cofilin regulation and cytoplasmic actin distribution .
22350022	0	HIF-1a	70,76	hypoxia-inducible_factor-1_alpha	36,68	HIF-1a	hypoxia-inducible factor-1 alpha	3091	3091	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinicopathological significance of hypoxia-inducible_factor-1_alpha -LRB- HIF-1a -RRB- expression in gastric_cancer .
22249478	0	HIF-1a	43,49	hypoxia-inducible_factor-1a	14,41	HIF-1a	hypoxia-inducible factor-1a	3091	3091	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
26113285	0	HIF-1a	43,49	hypoxia_inducible_factor-1a	14,41	HIF-1a	hypoxia inducible factor-1a	3091	3091	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Impact of the hypoxia_inducible_factor-1a -LRB- HIF-1a -RRB- pro582ser polymorphism and its gene expression on diabetic_foot_ulcers .
26113285	0	HIF-1a	43,49	hypoxia_inducible_factor-1a	14,41	HIF-1a	hypoxia inducible factor-1a	3091	3091	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Impact of the hypoxia_inducible_factor-1a -LRB- HIF-1a -RRB- pro582ser polymorphism and its gene expression on diabetic_foot_ulcers .
23263745	0	HIF-1a	25,31	isocitrate_dehydrogenase_2	45,71	HIF-1a	isocitrate dehydrogenase 2	3091	3418	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-183 upregulates HIF-1a by targeting isocitrate_dehydrogenase_2 -LRB- IDH2 -RRB- in glioma cells .
25385144	0	HIF-1a	58,64	miR-210	65,72	HIF-1a	miR-210	3091	406992	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1a / miR-210 / Bcl-2 pathway in colon_cancer cells .
25891797	0	HIF-1a	65,71	miR-33a	0,7	HIF-1a	miR-33a	3091	407039	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1a .
23979441	0	HIF-1a	71,77	snail	16,21	HIF-1a	snail	3091	6615	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Hypoxia-induced snail expression through transcriptional regulation by HIF-1a in pancreatic_cancer cells .
22455137	0	HIF-1alpha	45,55	BNIP3	15,20	HIF-1alpha	BNIP3	3091	664	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of BNIP3 and its correlations to HIF-1alpha and VEGF in clear_cell_renal_cell_carcinoma -RSB- .
18030615	0	HIF-1alpha	18,28	BRCA1	47,52	HIF-1alpha	BRCA1	3091	672	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|END_ENTITY	High frequency of HIF-1alpha overexpression in BRCA1 related breast_cancer .
20668552	0	HIF-1alpha	16,26	Bcl-2	0,5	HIF-1alpha	Bcl-2	3091	596	Gene	Gene	stabilization|compound|START_ENTITY regulates|dobj|stabilization regulates|nsubj|END_ENTITY	Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90 .
15184875	0	HIF-1alpha	38,48	CAIX	21,25	HIF-1alpha	CAIX	3091	768	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Strict regulation of CAIX -LRB- G250/MN -RRB- by HIF-1alpha in clear_cell_renal_cell_carcinoma .
19305150	0	HIF-1alpha	36,46	CCR7	16,20	HIF-1alpha	CCR7	3091	1236	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Hypoxia induced CCR7 expression via HIF-1alpha and HIF-2alpha correlates with migration and invasion in lung_cancer cells .
20738921	0	HIF-1alpha	59,69	CCR7	40,44	HIF-1alpha	CCR7	3091	1236	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Upregulation of the Chemokine Receptor CCR7 expression by HIF-1alpha and HIF-2alpha in non-small_cell_lung_cancer . -RSB- .
12149478	0	HIF-1alpha	55,65	Cited2	22,28	HIF-1alpha	Cited2	3091	10370	Gene	Gene	regulator|nmod|START_ENTITY role|appos|regulator role|nmod|END_ENTITY	The essential role of Cited2 , a negative regulator for HIF-1alpha , in heart development and neurulation .
19277991	0	HIF-1alpha	0,10	EP1	37,40	HIF-1alpha	EP1	3091	5731	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	HIF-1alpha regulates hypoxia-induced EP1 expression in osteoblastic cells .
18728783	0	HIF-1alpha	97,107	FGF2	0,4	HIF-1alpha	FGF2	3091	2247	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha .
17178925	0	HIF-1alpha	117,127	HIF-1alpha	84,94	HIF-1alpha	HIF-1alpha	3091	3091	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	ATP6V0C competes with von_Hippel-Lindau protein in hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- binding and mediates HIF-1alpha expression by bafilomycin_A1 .
17178925	0	HIF-1alpha	84,94	HIF-1alpha	117,127	HIF-1alpha	HIF-1alpha	3091	3091	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	ATP6V0C competes with von_Hippel-Lindau protein in hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- binding and mediates HIF-1alpha expression by bafilomycin_A1 .
20833713	0	HIF-1alpha	62,72	HO-1	16,20	HIF-1alpha	HO-1	29560(Tax:10116)	24451(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression .
20624301	0	HIF-1alpha	38,48	Hypoxia_inducible_factor_1alpha	0,31	HIF-1alpha	Hypoxia inducible factor 1alpha	3091	3091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hypoxia_inducible_factor_1alpha gene -LRB- HIF-1alpha -RRB- splice variants : potential prognostic biomarkers in breast_cancer .
20068160	0	HIF-1alpha	26,36	JNK1	0,4	HIF-1alpha	JNK1	3091	5599	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70 .
11707426	0	HIF-1alpha	29,39	Jab1	0,4	HIF-1alpha	Jab1	3091	10987	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Jab1 interacts directly with HIF-1alpha and regulates its stability .
19254710	0	HIF-1alpha	0,10	MXI1	19,23	HIF-1alpha	MXI1	3091	4601	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells .
17982282	0	HIF-1alpha	25,35	MgcRacGAP	0,9	HIF-1alpha	MgcRacGAP	3091	29127	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity .
18199827	0	HIF-1alpha	0,10	NFkappaB	64,72	HIF-1alpha	NFkappaB	15251(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling .
20889502	0	HIF-1alpha	104,114	Plk3	0,4	HIF-1alpha	Plk3	15251(Tax:10090)	12795(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha .
20001745	0	HIF-1alpha	43,53	Rac1	25,29	HIF-1alpha	Rac1	3091	5879	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha : a positive-feedback loop promoting pulmonary_vascular_remodeling .
18834862	0	HIF-1alpha	25,35	Stem_cell_factor	0,16	HIF-1alpha	Stem cell factor	3091	4254	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Stem_cell_factor induces HIF-1alpha at normoxia in hematopoietic cells .
17451682	0	HIF-1alpha	0,10	TNFalpha	107,115	HIF-1alpha	TNFalpha	3091	7124	Gene	Gene	expression|amod|START_ENTITY mediates|nsubj|expression mediates|dobj|induction induction|nmod|END_ENTITY	HIF-1alpha expression in response to lipopolysaccaride mediates induction of hepatic inflammatory cytokine TNFalpha .
19766100	0	HIF-1alpha	17,27	TNFalpha	0,8	HIF-1alpha	TNFalpha	3091	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNFalpha induces HIF-1alpha expression through activation of IKKbeta .
15705785	0	HIF-1alpha	134,144	Thrombopoietin	0,14	HIF-1alpha	Thrombopoietin	15251(Tax:10090)	21832(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY enhances|nmod|induction enhances|nsubj|END_ENTITY	Thrombopoietin enhances expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in primitive hematopoietic cells through induction of HIF-1alpha .
18473128	0	HIF-1alpha	31,41	Thrombopoietin	0,14	HIF-1alpha	Thrombopoietin	3091	7066	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species .
12709416	0	HIF-1alpha	90,100	VEGF	101,105	HIF-1alpha	VEGF	3091	7422	Gene	Gene	impairment|nmod|START_ENTITY exposure|dep|impairment exposure|dep|END_ENTITY	Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure : impairment of the HIF-1alpha / VEGF pathway .
14613646	0	HIF-1alpha	51,61	VEGF	120,124	HIF-1alpha	VEGF	3091	7422	Gene	Gene	hypoxia-inducible_factor_1_alpha|dep|START_ENTITY expression|amod|hypoxia-inducible_factor_1_alpha Relationship|nmod|expression Relationship|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- Relationship of hypoxia-inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- gene expression with vascular_endothelial_growth_factor -LRB- VEGF -RRB- and microvessel density -LRB- MVD -RRB- in human colorectal_adenoma and adenocarcinoma -RSB- .
15388333	0	HIF-1alpha	122,132	VEGF	38,42	HIF-1alpha	VEGF	3091	7422	Gene	Gene	protein|compound|START_ENTITY degradation|nmod|protein cells|nmod|degradation suppresses|nmod|cells suppresses|dobj|expression expression|nmod|END_ENTITY	Apigenin suppresses the expression of VEGF , an important factor for angiogenesis , in endothelial cells via degradation of HIF-1alpha protein .
15542432	0	HIF-1alpha	8,18	VEGF	66,70	HIF-1alpha	VEGF	3091	7422	Gene	Gene	Loss|nmod|START_ENTITY disrupts|nsubj|Loss disrupts|xcomp|necessary necessary|nsubj|loop loop|compound|END_ENTITY	Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis .
15583935	0	HIF-1alpha	115,125	VEGF	163,167	HIF-1alpha	VEGF	3091	7422	Gene	Gene	hypoxia-inducible_factor_1_alpha|appos|START_ENTITY inhibition|nmod|hypoxia-inducible_factor_1_alpha effects|dep|inhibition effects|dep|expression expression|appos|END_ENTITY	Anti-angiogenic effects of SN38 -LRB- active metabolite of irinotecan -RRB- : inhibition of hypoxia-inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- / vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression of glioma and growth of endothelial cells .
15705785	0	HIF-1alpha	134,144	VEGF	74,78	HIF-1alpha	VEGF	15251(Tax:10090)	22339(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY enhances|nmod|induction enhances|dobj|expression expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Thrombopoietin enhances expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in primitive hematopoietic cells through induction of HIF-1alpha .
15735682	0	HIF-1alpha	0,10	VEGF	145,149	HIF-1alpha	VEGF	3091	7422	Gene	Gene	START_ENTITY|parataxis|components components|nmod|complex complex|acl:relcl|regulates regulates|dobj|expression expression|nmod|END_ENTITY	HIF-1alpha , STAT3 , CBP/p300 and Ref-1 / APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic_and_prostate_carcinomas .
15958522	0	HIF-1alpha	11,21	VEGF	37,41	HIF-1alpha	VEGF	15251(Tax:10090)	22339(Tax:10090)	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|END_ENTITY	Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer .
16050135	0	HIF-1alpha	89,99	VEGF	47,51	HIF-1alpha	VEGF	3091	7422	Gene	Gene	downregulation|nmod|START_ENTITY suppresses|nmod|downregulation suppresses|dobj|expression expression|amod|END_ENTITY	Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells .
16598437	0	HIF-1alpha	80,90	VEGF	114,118	HIF-1alpha	VEGF	3091	7422	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Antiangiogenic effect of 2-benzoyl-phenoxy_acetamide in EAT cell is mediated by HIF-1alpha and down regulation of VEGF of in-vivo .
16612574	0	HIF-1alpha	47,57	VEGF	105,109	HIF-1alpha	VEGF	3091	7422	Gene	Gene	decreases|appos|START_ENTITY Inhibition|nmod|decreases vascular_endothelial_growth_factor|nsubj|Inhibition vascular_endothelial_growth_factor|xcomp|growth growth|dep|END_ENTITY	Inhibition of hypoxia_inducible_factor-1alpha -LRB- HIF-1alpha -RRB- decreases vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion and tumor growth in malignant_gliomas .
16718928	0	HIF-1alpha	90,100	VEGF	127,131	HIF-1alpha	VEGF	3091	7422	Gene	Gene	site|compound|START_ENTITY site|nmod|promoter promoter|compound|END_ENTITY	Inhibition of the VEGF expression and cell growth in hepatocellular_carcinoma by blocking HIF-1alpha and Smad3 binding site in VEGF promoter .
16718928	0	HIF-1alpha	90,100	VEGF	18,22	HIF-1alpha	VEGF	3091	7422	Gene	Gene	site|compound|START_ENTITY blocking|dobj|site hepatocellular_carcinoma|acl|blocking expression|nmod|hepatocellular_carcinoma expression|compound|END_ENTITY	Inhibition of the VEGF expression and cell growth in hepatocellular_carcinoma by blocking HIF-1alpha and Smad3 binding site in VEGF promoter .
17442277	0	HIF-1alpha	68,78	VEGF	35,39	HIF-1alpha	VEGF	3091	7422	Gene	Gene	degradation|compound|START_ENTITY inducing|dobj|degradation inhibited|advcl|inducing inhibited|dobj|expression expression|amod|END_ENTITY	Benzo -LSB- a -RSB- pyrene-3 ,6 - dione inhibited VEGF expression through inducing HIF-1alpha degradation .
18027712	0	HIF-1alpha	46,56	VEGF	19,23	HIF-1alpha	VEGF	3091	7422	Gene	Gene	-RSB-|compound|START_ENTITY induced|nmod|-RSB- induced|csubj|-LSB- -LSB-|dobj|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	-LSB- The inhibition of VEGF expression induced by HIF-1alpha RNA interference -RSB- .
18452596	0	HIF-1alpha	34,44	VEGF	94,98	HIF-1alpha	VEGF	3091	7422	Gene	Gene	significance|nmod|START_ENTITY END_ENTITY|nsubj|significance	Clinicopathologic significance of HIF-1alpha , p53 , and VEGF expression and preoperative serum VEGF level in gastric_cancer .
19131542	0	HIF-1alpha	57,67	VEGF	28,32	HIF-1alpha	VEGF	3091	7422	Gene	Gene	expression|compound|START_ENTITY reducing|dobj|expression expression|acl|reducing expression|amod|END_ENTITY	Grape_seed_extract inhibits VEGF expression via reducing HIF-1alpha protein expression .
19569175	0	HIF-1alpha	83,93	VEGF	94,98	HIF-1alpha	VEGF	3091	7422	Gene	Gene	angiogenesis|nmod|START_ENTITY angiogenesis|parataxis|signaling signaling|nsubj|END_ENTITY	Bisphosphonates suppress insulin-like_growth_factor_1-induced angiogenesis via the HIF-1alpha / VEGF signaling pathways in human breast_cancer cells .
20353560	0	HIF-1alpha	29,39	VEGF	111,115	HIF-1alpha	VEGF	3091	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|reduction reduction|nmod|END_ENTITY	Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions ; significant reduction of VEGF by CaMKII inhibitor .
20724477	0	HIF-1alpha	155,165	VEGF	25,29	HIF-1alpha	VEGF	3091	7422	Gene	Gene	protein|compound|START_ENTITY level|nmod|protein promotes|nmod|level promotes|dobj|expression expression|amod|END_ENTITY	Carbon_monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms , translational activation and stabilization of HIF-1alpha protein .
20724477	0	HIF-1alpha	55,65	VEGF	25,29	HIF-1alpha	VEGF	3091	7422	Gene	Gene	level|compound|START_ENTITY promotes|nmod|level promotes|dobj|expression expression|amod|END_ENTITY	Carbon_monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms , translational activation and stabilization of HIF-1alpha protein .
21576240	0	HIF-1alpha	98,108	VEGF	150,154	HIF-1alpha	VEGF	3091	7422	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- by regulating 26 S proteasome-mediated protein degradation in human colon_cancer cells .
16080559	0	HIF-1alpha	40,50	VEGF-C	53,59	HIF-1alpha	VEGF-C	3091	7424	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of hypoxia-inducible factor -LRB- HIF-1alpha -RRB- , VEGF-C and VEGF-D in non-invasive and invasive breast ductal_carcinomas .
17219968	0	HIF-1alpha	10,20	VEGF-C	24,30	HIF-1alpha	VEGF-C	3091	7424	Gene	Gene	START_ENTITY|nmod|induced induced|compound|END_ENTITY	Effect of HIF-1alpha on VEGF-C induced lymphangiogenesis and lymph nodes metastases of pancreatic_cancer .
11504942	0	HIF-1alpha	0,10	VHL	22,25	HIF-1alpha	VHL	3091	7428	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation .
12205091	0	HIF-1alpha	11,21	VHL	62,65	HIF-1alpha	VHL	3091	7428	Gene	Gene	Leu-574|nmod|START_ENTITY essential|nsubj|Leu-574 essential|nmod|von_Hippel-Lindau von_Hippel-Lindau|appos|END_ENTITY	Leu-574 of HIF-1alpha is essential for the von_Hippel-Lindau -LRB- VHL -RRB- - mediated degradation pathway .
12682018	0	HIF-1alpha	66,76	VHL	4,7	HIF-1alpha	VHL	3091	7428	Gene	Gene	activity|compound|START_ENTITY recruits|nmod|activity recruits|nsubj|protein protein|compound|END_ENTITY	The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity .
16954163	0	HIF-1alpha	14,24	VHL	112,115	HIF-1alpha	VHL	3091	7428	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|mutations mutations|compound|END_ENTITY	Expression of HIF-1alpha , HIF-2alpha -LRB- EPAS1 -RRB- , and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations .
18717335	0	HIF-1alpha	38,48	VHL	67,70	HIF-1alpha	VHL	3091	7428	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	-LSB- Hydroxysafflor_yellow_A up-regulates HIF-1alpha via inhibition of VHL and p53 in Eahy 926 cell line exposed to hypoxia -RSB- .
20075985	0	HIF-1alpha	19,29	VHL	79,82	HIF-1alpha	VHL	3091	7428	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of HIF-1alpha by oncolytic reovirus_infection independently of VHL and p53 .
20599784	0	HIF-1alpha	66,76	VHL	97,100	HIF-1alpha	VHL	3091	7428	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	LW6 , a novel HIF-1 inhibitor , promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon_cancer cell line .
15147973	0	HIF-1alpha	139,149	bisphenol_A	178,189	HIF-1alpha	bisphenol A	3091	667	Gene	Gene	START_ENTITY|dep|requirement requirement|nmod|END_ENTITY	Bisphenol_A , an environmental endocrine-disrupting chemical , inhibits hypoxic response via degradation of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- : structural requirement of bisphenol_A for degradation of HIF-1alpha .
15147973	0	HIF-1alpha	209,219	bisphenol_A	178,189	HIF-1alpha	bisphenol A	3091	667	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	Bisphenol_A , an environmental endocrine-disrupting chemical , inhibits hypoxic response via degradation of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- : structural requirement of bisphenol_A for degradation of HIF-1alpha .
20448047	0	HIF-1alpha	106,116	early_growth_response_1	31,54	HIF-1alpha	early growth response 1	3091	1958	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Placenta_growth_factor-induced early_growth_response_1 -LRB- Egr-1 -RRB- regulates hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- in endothelial cells .
20404921	0	HIF-1alpha	49,59	erythropoietin	86,100	HIF-1alpha	erythropoietin	15251(Tax:10090)	13856(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity .
12193413	0	HIF-1alpha	49,59	hypoxia-inducible_factor-1_alpha	15,47	HIF-1alpha	hypoxia-inducible factor-1 alpha	29560(Tax:10116)	29560(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Stimulation of hypoxia-inducible_factor-1_alpha -LRB- HIF-1alpha -RRB- protein in the adult rat testis following ischemic_injury occurs without an increase in HIF-1alpha messenger RNA expression .
17848618	0	HIF-1alpha	191,201	hypoxia-inducible_factor-1_alpha	157,189	HIF-1alpha	hypoxia-inducible factor-1 alpha	3091	3091	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The new tumor-suppressor gene inhibitor of growth family member 4 -LRB- ING4 -RRB- regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible_factor-1_alpha -LRB- HIF-1alpha -RRB- activity : involvement in myeloma-induced angiogenesis .
18565696	0	HIF-1alpha	86,96	hypoxia-inducible_factor-1_alpha	52,84	HIF-1alpha	hypoxia-inducible factor-1 alpha	3091	3091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variable patterns in the molecular evolution of the hypoxia-inducible_factor-1_alpha -LRB- HIF-1alpha -RRB- gene in teleost fishes and mammals .
15538748	0	HIF-1alpha	51,61	hypoxia-inducible_factor-1alpha	18,49	HIF-1alpha	hypoxia-inducible factor-1alpha	3091	3091	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Identification of hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- polymorphism as a mutation in prostate_cancer that prevents normoxia-induced degradation .
16464515	0	HIF-1alpha	116,126	hypoxia-inducible_factor-1alpha	83,114	HIF-1alpha	hypoxia-inducible factor-1alpha	29560(Tax:10116)	29560(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- protein following focal cerebral_ischemia in rats .
18279708	0	HIF-1alpha	72,82	hypoxia-inducible_factor-1alpha	39,70	HIF-1alpha	hypoxia-inducible factor-1alpha	3091	3091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms in the hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- gene in human sporadic_breast_cancer .
16157596	0	HIF-1alpha	48,58	hypoxia-inducible_factor_1alpha	15,46	HIF-1alpha	hypoxia-inducible factor 1alpha	3091	3091	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Suppression of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- transcriptional activity by the HIF prolyl hydroxylase EGLN1 .
19149949	0	HIF-1alpha	55,65	hypoxia_inducible_factor_1alpha	22,53	HIF-1alpha	hypoxia inducible factor 1alpha	3091	3091	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	-LSB- Effect of hypoxia on hypoxia_inducible_factor_1alpha -LRB- HIF-1alpha -RRB- activation in intestinal epithelial cells -RSB- .
16516166	0	HIF-1alpha	43,53	insulin	65,72	HIF-1alpha	insulin	3091	3630	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1 .
18166158	0	HIF-1alpha	0,10	p21	64,67	HIF-1alpha	p21	3091	1026	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	HIF-1alpha controls keratinocyte proliferation by up-regulating p21 -LRB- WAF1/Cip1 -RRB- .
20616349	0	HIF-1alpha	49,59	p38MAPK	60,67	HIF-1alpha	p38MAPK	15251(Tax:10090)	26416(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Morphine suppresses tumor angiogenesis through a HIF-1alpha / p38MAPK pathway .
20478051	0	HIF-1beta	107,116	Ezh2	34,38	HIF-1beta	Ezh2	405	2146	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen_receptor and HIF-1alpha / HIF-1beta .
17507435	0	HIF-2_alpha	23,34	HIF-1_alpha	10,21	HIF-2 alpha	HIF-1 alpha	2034	3091	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|appos|proteins	Placental HIF-1_alpha , HIF-2_alpha , membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine_growth_restriction .
11888900	0	HIF-2_alpha	46,57	hypoxia-inducible_factor-2_alpha	12,44	HIF-2 alpha	hypoxia-inducible factor-2 alpha	2034	2034	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Relation of hypoxia-inducible_factor-2_alpha -LRB- HIF-2_alpha -RRB- expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast_cancer .
26307391	0	HIF-2a	0,6	CDCP1	17,22	HIF-2a	CDCP1	2034	64866	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HIF-2a regulates CDCP1 to promote PKC - mediated migration_in_hepatocellular_carcinoma .
26943772	0	HIF-2a	104,110	Dicer	0,5	HIF-2a	Dicer	2034	23405	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Dicer suppresses the malignant phenotype in VHL-deficient_clear_cell_renal_cell_carcinoma by inhibiting HIF-2a .
25271810	0	HIF-2a	0,6	NANOG	17,22	HIF-2a	NANOG	2034	79923	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	HIF-2a regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element .
26868537	0	HIF-2a	103,109	Notch3	110,116	HIF-2a	Notch3	13819(Tax:10090)	18131(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	LPS causes pericyte loss and microvascular_dysfunction via disruption of Sirt3/angiopoietins/Tie -2 and HIF-2a / Notch3 pathways .
26136997	0	HIF-2a	21,27	Osteopontin	0,11	HIF-2a	Osteopontin	2034	6696	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Osteopontin inhibits HIF-2a mRNA expression in osteoarthritic chondrocytes .
26898802	0	HIF-2a	18,24	Ptpmt1	0,6	HIF-2a	Ptpmt1	2034	114971	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Ptpmt1 induced by HIF-2a regulates the proliferation and glucose metabolism in erythroleukemia cells .
22689594	0	HIF-2a	0,6	p53	18,21	HIF-2a	p53	2034	7157	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	HIF-2a suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells .
19541651	0	HIF-2alpha	56,66	Adenosine_A2A_receptor	0,22	HIF-2alpha	Adenosine A2A receptor	2034	135	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Adenosine_A2A_receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells .
12670588	0	HIF-2alpha	56,66	EPAS-1	49,55	HIF-2alpha	EPAS-1	2034	2034	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Correlation study showing no concordance between EPAS-1 / HIF-2alpha mRNA and protein expression in transitional cellcancer of the bladder .
11992927	0	HIF-2alpha	23,33	EPAS1	34,39	HIF-2alpha	EPAS1	2034	2034	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Positive expression of HIF-2alpha / EPAS1 in invasive bladder_cancer .
14966910	0	HIF-2alpha	14,24	EPAS1	25,30	HIF-2alpha	EPAS1	2034	2034	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of HIF-2alpha / EPAS1 in hepatocellular_carcinoma .
16510872	0	HIF-2alpha	0,10	Oct-4	21,26	HIF-2alpha	Oct-4	2034	5460	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HIF-2alpha regulates Oct-4 : effects of hypoxia on stem cell function , embryonic development , and tumor growth .
18451309	0	HIF-2alpha	56,66	VCAM-1	75,81	HIF-2alpha	VCAM-1	13819(Tax:10090)	22329(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells .
15240563	0	HIF-2alpha	153,163	erythropoietin	133,147	HIF-2alpha	erythropoietin	2034	2056	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Differentiating the functional role of hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 alpha and HIF-2alpha -LRB- EPAS-1 -RRB- by the use of RNA interference : erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells .
12697324	0	HIF-2alpha	0,10	glyceraldehyde-3-phosphate_dehydrogenase	21,61	HIF-2alpha	glyceraldehyde-3-phosphate dehydrogenase	2034	2597	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	HIF-2alpha regulates glyceraldehyde-3-phosphate_dehydrogenase expression in endothelial cells .
16394508	0	HIF-2alpha	67,77	hypoxia_inducible_factor-2alpha	34,65	HIF-2alpha	hypoxia inducible factor-2alpha	13819(Tax:10090)	13819(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the hypoxia_inducible_factor-2alpha -LRB- HIF-2alpha -RRB- gene during adipose differentiation in 3T3-L1 cells .
22186139	0	HIF1	34,38	Myc	0,3	HIF1	Myc	3091	4609	Gene	Gene	protein|compound|START_ENTITY induces|dobj|protein induces|nsubj|END_ENTITY	Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells .
23792163	0	HIF1	0,4	WSB-1	15,20	HIF1	WSB-1	3091	26118	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular_carcinoma cells .
27094789	0	HIF1A	30,35	PI3K	84,88	HIF1A	PI3K	3091	5295	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|advcl|activating activating|dobj|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- induces HIF1A and TGFA expression in MCF7 cells by activating PI3K .
20540786	0	HIF1A	143,148	SLC2A1	108,114	HIF1A	SLC2A1	3091	6513	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The association of 18F-deoxyglucose -LRB- FDG -RRB- uptake of PET with polymorphisms in the glucose transporter gene -LRB- SLC2A1 -RRB- and hypoxia-related genes -LRB- HIF1A , VEGFA , APEX1 -RRB- in non-small_cell_lung_cancer .
20299614	0	HIF1A	90,95	hypoxia-inducible_factor-1alpha	57,88	HIF1A	hypoxia-inducible factor-1alpha	3091	3091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible_factor-1alpha -LRB- HIF1A -RRB- gene in elite endurance athletes .
24232601	0	HIF1A	78,83	hypoxia-inducible_factor_1A	49,76	HIF1A	hypoxia-inducible factor 1A	3091	3091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between the polymorphisms of hypoxia-inducible_factor_1A -LRB- HIF1A -RRB- gene and SLE susceptibility in a Chinese population .
15350301	0	HIF1A	59,64	hypoxia_inducible_factor-1alpha	21,52	HIF1A	hypoxia inducible factor-1alpha	3091	3091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the hypoxia_inducible_factor-1alpha gene -LRB- HIF1A -RRB- are associated with the renal_cell_carcinoma phenotype .
25727291	0	HIF1a	25,30	AML1/ETO	0,8	HIF1a	AML1/ETO	3091	861;862	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	AML1/ETO cooperates with HIF1a to promote leukemogenesis through DNMT3a transactivation .
24931519	0	HIF1a	10,15	CD25	44,48	HIF1a	CD25	3091	3559	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
24931519	0	HIF1a	10,15	CD4	39,42	HIF1a	CD4	3091	920	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|CD25 CD25|compound|END_ENTITY	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
24931519	0	HIF1a	10,15	Foxp3	19,24	HIF1a	Foxp3	3091	50943	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of HIF1a on Foxp3 expression in CD4 + CD25 - T lymphocytes .
24333432	0	HIF1a	27,32	GSK3b	0,5	HIF1a	GSK3b	3091	2932	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	GSK3b negatively regulates HIF1a mRNA stability via nucleolin in the MG63 osteosarcoma cell line .
25705708	0	HIF1a	23,28	MTA1	0,4	HIF1a	MTA1	3091	9112	Gene	Gene	Expression|compound|START_ENTITY Regulate|dobj|Expression Regulate|nsubj|END_ENTITY	MTA1 and MTA3 Regulate HIF1a Expression in Hypoxia-Treated Human Trophoblast Cell Line HTR8/Svneo .
23563312	0	HIF1a	0,5	SRC	39,42	HIF1a	SRC	15251(Tax:10090)	20779(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	HIF1a and HIF2a independently activate SRC to promote melanoma metastases .
25971970	0	HIF1a	28,33	Snail	0,5	HIF1a	Snail	3091	6615	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Snail is a Direct Target of HIF1a in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells .
26287601	0	HIF1a	78,83	VEGFa	103,108	HIF1a	VEGFa	3091	7422	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	NCOA1 promotes angiogenesis in breast_tumors by simultaneously enhancing both HIF1a - and AP-1-mediated VEGFa transcription .
22467238	0	HIF1a	0,5	XPA	30,33	HIF1a	XPA	3091	7507	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	HIF1a regulated expression of XPA contributes to cisplatin resistance in lung_cancer .
25349289	0	HIF1a	0,5	mTOR	16,20	HIF1a	mTOR	15251(Tax:10090)	21977(Tax:10090)	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	HIF1a Regulates mTOR Signaling and Viability of Prostate_Cancer Stem Cells .
26205124	0	HIF1a	35,40	miR-182	18,25	HIF1a	miR-182	15251(Tax:10090)	387177(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Hypoxia-inducible miR-182 enhances HIF1a signaling via targeting PHD2 and FIH1 in prostate cancer .
26205124	0	HIF1a	35,40	miR-182	18,25	HIF1a	miR-182	15251(Tax:10090)	387177(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Hypoxia-inducible miR-182 enhances HIF1a signaling via targeting PHD2 and FIH1 in prostate cancer .
24333432	0	HIF1a	27,32	nucleolin	52,61	HIF1a	nucleolin	3091	4691	Gene	Gene	stability|amod|START_ENTITY stability|nmod|END_ENTITY	GSK3b negatively regulates HIF1a mRNA stability via nucleolin in the MG63 osteosarcoma cell line .
26681691	0	HIF1a-E2F7	46,56	NRP1	29,33	HIF1a-E2F7	NRP1	797150;567941	353246(Tax:7955)	Gene	Gene	target|compound|START_ENTITY END_ENTITY|nmod|target	Genome-wide analysis reveals NRP1 as a direct HIF1a-E2F7 target in the regulation of motorneuron guidance in vivo .
17913788	0	HIF1alpha	0,9	Sox9	24,28	HIF1alpha	Sox9	15251(Tax:10090)	20682(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis .
14712484	0	HIF1alpha	33,42	VEGF	27,31	HIF1alpha	VEGF	3091	7422	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of VEGF , HIF1alpha and angiopoietin-1 , _ -2 _ and _ -4 by hypoxia and ionizing radiation in human glioblastoma .
17292638	0	HIF1alpha	54,63	hypoxia_inducible_factor_1alpha	21,52	HIF1alpha	hypoxia inducible factor 1alpha	3091	3091	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Association study of hypoxia_inducible_factor_1alpha -LRB- HIF1alpha -RRB- with osteonecrosis of femoral head in a Korean population .
23418310	0	HIF2A	15,20	EPAS1	8,13	HIF2A	EPAS1	2034	2034	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Tumoral EPAS1 -LRB- HIF2A -RRB- mutations explain sporadic pheochromocytoma and paraganglioma in the absence of erythrocytosis .
26148512	0	HIF2a	33,38	Cezanne	0,7	HIF2a	Cezanne	2034	56957	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cezanne regulates E2F1-dependent HIF2a expression .
23103253	0	HIF2a	0,5	SLC7A5	65,71	HIF2a	SLC7A5	2034	8140	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	HIF2a acts as an mTORC1 activator through the amino_acid carrier SLC7A5 .
21263150	0	HIF2alpha	18,27	STAT5	44,49	HIF2alpha	STAT5	2034	6776	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells .
21139050	0	HIMF	51,55	hypoxia-induced_mitogenic_factor	17,49	HIMF	hypoxia-induced mitogenic factor	57262(Tax:10090)	57262(Tax:10090)	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	S100A11 mediates hypoxia-induced_mitogenic_factor -LRB- HIMF -RRB- - induced smooth muscle cell migration , vesicular exocytosis , and nuclear activation .
22647378	0	HINT1	21,26	MITF	37,41	HINT1	MITF	3094	4286	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The tumor suppressor HINT1 regulates MITF and b-catenin transcriptional activity in melanoma cells .
25648896	0	HINT1	129,134	MITF	84,88	HINT1	MITF	3094	4286	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|activity activity|nmod|END_ENTITY	The intracellular_domain of teneurin-1 induces the activity of transcription factor MITF by binding to transcriptional repressor HINT1 .
20514075	0	HINT1	65,70	histidine-triad_nucleotide-binding_protein-1	19,63	HINT1	histidine-triad nucleotide-binding protein-1	3094	3094	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the histidine-triad_nucleotide-binding_protein-1 -LRB- HINT1 -RRB- gene variants with nicotine_dependence .
18799291	0	HINT1	53,58	histidine_triad_nucleotide-binding_protein_1	7,51	HINT1	histidine triad nucleotide-binding protein 1	3094	3094	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Is the histidine_triad_nucleotide-binding_protein_1 -LRB- HINT1 -RRB- gene a candidate for schizophrenia ?
7087670	0	HIOMT	71,76	hydroxy-indole-o-methyl-transferase	34,69	HIOMT	hydroxy-indole-o-methyl-transferase	438	438	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of avian and mammalian hydroxy-indole-o-methyl-transferase -LRB- HIOMT -RRB- with low molecular weight fractions of mammalian pineal glands .
6180129	0	HIOMT	76,81	hydroxyindole-O-methyl_transferase	40,74	HIOMT	hydroxyindole-O-methyl transferase	246281(Tax:10116)	246281(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Changes in the circadian rhythmicity of hydroxyindole-O-methyl_transferase -LRB- HIOMT -RRB- activity in the synthesis of 5-methoxyindoles in the pineal gland of 28 day old male Wistar_rats exposed to white , red and green light .
10067865	0	HIOMT	72,77	hydroxyindole-O-methyltransferase	37,70	HIOMT	hydroxyindole-O-methyltransferase	246281(Tax:10116)	246281(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase -LRB- HIOMT -RRB- messenger ribonucleic acid expression : an analysis of its complex relationship with HIOMT activity .
10831155	0	HIOMT	52,57	hydroxyindole-O-methyltransferase	17,50	HIOMT	hydroxyindole-O-methyltransferase	438	438	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Demonstration of hydroxyindole-O-methyltransferase -LRB- HIOMT -RRB- mRNA expression in pineal_parenchymal_tumors : histochemical in situ hybridization .
11471145	0	HIOMT	70,75	hydroxyindole-o-methyltransferase	35,68	HIOMT	hydroxyindole-o-methyltransferase	438	438	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of hydroxyindole-o-methyltransferase -LRB- HIOMT -RRB- in the brain of Myoisophagos lacteus -LRB- Nemertea : Heteronemertea : Lineidae -RRB- .
14557276	0	HIP-55	34,40	c-Jun_N-terminal_kinase	50,73	HIP-55	c-Jun N-terminal kinase	28988	5599	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	The SH3 domain-containing adaptor HIP-55 mediates c-Jun_N-terminal_kinase activation in T cell receptor signaling .
17623017	0	HIP1	77,81	HIPPI	16,21	HIP1	HIPPI	3092	55081	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Interactions of HIPPI , a molecular partner of Huntingtin interacting protein HIP1 , with the specific motif present at the putative promoter sequence of the caspase-1 , _ caspase-8 and caspase-10 genes .
9140394	0	HIP1	0,4	Sla2p	41,46	HIP1	Sla2p	3092	855478(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	HIP1 , a human homologue of S. _ cerevisiae Sla2p , interacts with membrane-associated huntingtin in the brain .
3905514	0	HIP1	29,33	histidine_permease	4,22	HIP1	histidine permease	853104(Tax:4932)	853104(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The histidine_permease gene -LRB- HIP1 -RRB- of Saccharomyces_cerevisiae .
21636527	0	HIP14	85,90	HTT	10,13	HIP14	HTT	320150(Tax:10090)	15194(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14 .
24651384	0	HIP14	86,91	Huntingtin	35,45	HIP14	Huntingtin	23390	3064	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L .
16390825	0	HIPK1	20,25	DJ-1	0,4	HIPK1	DJ-1	204851	11315	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DJ-1 interacts with HIPK1 and affects H2O2-induced cell death .
19646965	0	HIPK1	0,5	c-Myb	21,26	HIPK1	c-Myb	204851	4602	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HIPK1 interacts with c-Myb and modulates its activity through phosphorylation .
25659434	0	HIPK2	139,144	Homeodomain_Interacting_Protein_Kinase_2	97,137	HIPK2	Homeodomain Interacting Protein Kinase 2	28996	28996	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of Kruppel-like Factor 3 -LRB- KLF3/BKLF -RRB- and C-terminal_Binding_Protein_2 -LRB- CtBP2 -RRB- by Homeodomain_Interacting_Protein_Kinase_2 -LRB- HIPK2 -RRB- Modulates KLF3 DNA Binding and Activity .
19638586	0	HIPK2	0,5	MDM2	20,24	HIPK2	MDM2	28996	4193	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating_drugs_nutlin-3_and_RITA .
18695000	0	HIPK2	67,72	RUNX1	49,54	HIPK2	RUNX1	28996	861	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2 : implications for leukemogenesis .
12220523	0	HIPK2	0,5	RanBPM	22,28	HIPK2	RanBPM	28996	10048	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	HIPK2 associates with RanBPM .
14990717	0	HIPK2	51,56	US11	0,4	HIPK2	US11	28996	2703439(Tax:10298)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	US11 of herpes_simplex_virus_type_1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest .
23871434	0	HIPK2	73,78	WIP1	0,4	HIPK2	WIP1	15258(Tax:10090)	53892(Tax:10090)	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	WIP1 , a homeostatic regulator of the DNA damage response , is targeted by HIPK2 for phosphorylation and degradation .
19448668	0	HIPK2	25,30	ZBTB4	104,109	HIPK2	ZBTB4	28996	57659	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4 .
11532197	0	HIPK2	0,5	p53	47,50	HIPK2	p53	28996	7157	Gene	Gene	overexpression|compound|START_ENTITY leads|nsubj|overexpression leads|nmod|stabilization stabilization|nmod|protein protein|compound|END_ENTITY	HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels .
12851404	0	HIPK2	56,61	p53	90,93	HIPK2	p53	28996	7157	Gene	Gene	TP53INP1s|appos|START_ENTITY partners|nsubj|TP53INP1s partners|acl|regulating regulating|dobj|activity activity|compound|END_ENTITY	TP53INP1s and homeodomain-interacting_protein_kinase-2 -LRB- HIPK2 -RRB- are partners in regulating p53 activity .
12907596	0	HIPK2	62,67	p53	78,81	HIPK2	p53	28996	7157	Gene	Gene	homeodomain-interacting_protein_kinase_2|appos|START_ENTITY homeodomain-interacting_protein_kinase_2|dep|phosphorylation phosphorylation|compound|END_ENTITY	PML is required for homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- - mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains .
15122315	0	HIPK2	0,5	p53	43,46	HIPK2	p53	28996	7157	Gene	Gene	neutralizes|nsubj|START_ENTITY neutralizes|dobj|inhibition inhibition|acl|rescuing rescuing|dobj|activity activity|compound|END_ENTITY	HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function .
15526030	0	HIPK2	47,52	p53	16,19	HIPK2	p53	28996	7157	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase stimulates|nmod|activation stimulates|dobj|functions functions|compound|END_ENTITY	Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation .
15897882	0	HIPK2	0,5	p53	35,38	HIPK2	p53	28996	7157	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|acetylation acetylation|compound|END_ENTITY	HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage .
16601678	0	HIPK2	77,82	p53	30,33	HIPK2	p53	28996	7157	Gene	Gene	control|nmod|START_ENTITY control|nmod|response response|compound|END_ENTITY	Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2 .
17290307	0	HIPK2	96,101	p53	32,35	HIPK2	p53	28996	7157	Gene	Gene	relocalization|nmod|START_ENTITY inhibits|nmod|relocalization inhibits|dobj|END_ENTITY	High-mobility_group_A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 .
19642869	0	HIPK2	63,68	p53	30,33	HIPK2	p53	28996	7157	Gene	Gene	degradation|compound|START_ENTITY control|nmod|degradation control|nmod|response response|compound|END_ENTITY	Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation .
19828042	0	HIPK2	0,5	p53	16,19	HIPK2	p53	28996	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	HIPK2 modulates p53 activity towards pro-apoptotic transcription .
20018442	0	HIPK2	93,98	p53	49,52	HIPK2	p53	28996	7157	Gene	Gene	degradation|compound|START_ENTITY triggering|dobj|degradation suppresses|advcl|triggering suppresses|dobj|phosphorylation phosphorylation|nummod|END_ENTITY	Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation .
20514025	0	HIPK2	30,35	p53	14,17	HIPK2	p53	28996	7157	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of p53 activity by HIPK2 : molecular mechanisms and therapeutical implications in human cancer cells .
20876941	0	HIPK2	60,65	p53	9,12	HIPK2	p53	28996	7157	Gene	Gene	link|compound|START_ENTITY is|nsubj|link is|dobj|END_ENTITY	Unfolded p53 in the pathogenesis of Alzheimer 's _ disease : is HIPK2 the link ?
22110707	0	HIPK2	73,78	p53	28,31	HIPK2	p53	28996	7157	Gene	Gene	interaction|nmod|START_ENTITY prevents|nmod|interaction prevents|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2 .
24177473	0	HIPK2	108,113	p53	44,47	HIPK2	p53	28996	7157	Gene	Gene	relocalization|nmod|START_ENTITY inhibits|nmod|relocalization inhibits|dobj|END_ENTITY	Retraction : High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 .
24196445	0	HIPK2	59,64	p53	35,38	HIPK2	p53	15258(Tax:10090)	22060(Tax:10090)	Gene	Gene	localization|compound|START_ENTITY altering|dobj|localization modulates|advcl|altering modulates|dobj|pathway pathway|compound|END_ENTITY	Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization .
25313037	0	HIPK2	69,74	p53	33,36	HIPK2	p53	28996	7157	Gene	Gene	activation|nmod|START_ENTITY signaling|nmod|activation END_ENTITY|acl|signaling	XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313 .
22236966	0	HIPK2	0,5	vimentin	20,28	HIPK2	vimentin	28996	7431	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	HIPK2 downregulates vimentin and inhibits breast_cancer cell invasion .
14766760	0	HIPK3	14,19	JNK	0,3	HIPK3	JNK	10114	5599	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate_carcinoma cells .
20508833	0	HIPK4	68,73	Homeodomain-interacting_Protein_Kinase_4	26,66	HIPK3	Homeodomain-interacting Protein Kinase 4	10114	147746	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Human Homeodomain-interacting_Protein_Kinase_4 -LRB- HIPK4 -RRB- as a Unique Member of the HIPK Family .
17623017	0	HIPPI	16,21	HIP1	77,81	HIPPI	HIP1	55081	3092	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Interactions of HIPPI , a molecular partner of Huntingtin interacting protein HIP1 , with the specific motif present at the putative promoter sequence of the caspase-1 , _ caspase-8 and caspase-10 genes .
25197097	0	HIRA	70,74	EKLF	21,25	HIRA	EKLF	7290	10661	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	Transcription factor EKLF -LRB- KLF1 -RRB- recruitment of the histone chaperone HIRA is essential for b-globin gene expression .
11238922	0	HIRA	0,4	Hir1p	35,40	HIRA	Hir1p	7290	852275(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	HIRA , the human homologue of yeast Hir1p and Hir2p , is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression .
9731536	0	HIRA	0,4	Pax3	102,106	HIRA	Pax3	7290	18505(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HIRA , a mammalian homologue of Saccharomyces_cerevisiae transcriptional co-repressors , interacts with Pax3 .
2683089	0	HIS4	35,39	BAS2	79,83	HIS4	BAS2	850327(Tax:4932)	851452(Tax:4932)	Gene	Gene	transcription|nummod|START_ENTITY activates|dobj|transcription activates|nmod|END_ENTITY	BAS1 has a Myb motif and activates HIS4 transcription only in combination with BAS2 .
21398257	0	HISTONE_DEACETYLASE6	0,20	FLOWERING_LOCUS_D	36,53	HISTONE DEACETYLASE6	FLOWERING LOCUS D	836431(Tax:3702)	820202(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HISTONE_DEACETYLASE6 interacts with FLOWERING_LOCUS_D and regulates flowering in Arabidopsis .
24178558	0	HITS-CLIP	0,9	Piwi	31,35	HITS-CLIP	Piwi	18976(Tax:10090)	34521(Tax:7227)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	HITS-CLIP -LRB- CLIP-Seq -RRB- for mouse Piwi proteins .
19410545	0	HJURP	0,5	CENP-A	69,75	HJURP	CENP-A	55355	1058	Gene	Gene	maintenance|nsubj|START_ENTITY maintenance|nmod|END_ENTITY	HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres .
20080577	0	HJURP	0,5	CENP-A	12,18	HJURP	CENP-A	55355	1058	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres .
21321101	0	HJURP	8,13	CENP-A	48,54	HJURP	CENP-A	100861527	735079(Tax:8355)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|assembly assembly|amod|END_ENTITY	Xenopus HJURP and condensin II are required for CENP-A assembly .
21768289	0	HJURP	0,5	CENP-A	11,17	HJURP	CENP-A	55355	1058	Gene	Gene	factor|nsubj|START_ENTITY factor|amod|END_ENTITY	HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore .
22406139	0	HJURP	0,5	CENP-A	20,26	HJURP	CENP-A	55355	1058	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|surfaces surfaces|amod|END_ENTITY	HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly .
23792427	0	HJURP	20,25	CENP-A	46,52	HJURP	CENP-A	55355	1058	Gene	Gene	dimerization|compound|START_ENTITY drives|nsubj|dimerization drives|dobj|assembly assembly|amod|END_ENTITY	How two become one : HJURP dimerization drives CENP-A assembly .
25001279	0	HJURP	35,40	CENP-A	101,107	HJURP	CENP-A	55355	1058	Gene	Gene	binding|nmod|START_ENTITY determine|nsubj|binding determine|dobj|recruitment recruitment|nmod|loading loading|appos|END_ENTITY	Phosphorylation and DNA binding of HJURP determine its centromeric recruitment and function in CenH3 -LRB- CENP-A -RRB- loading .
25843710	0	HJURP	0,5	CENP-A	35,41	HJURP	CENP-A	55355	1058	Gene	Gene	Involvement|compound|START_ENTITY Involvement|nmod|CenH3 CenH3|appos|END_ENTITY	HJURP Involvement in De Novo CenH3 -LRB- CENP-A -RRB- and CENP-C Recruitment .
19410544	0	HJURP	66,71	CENP-a	32,38	HJURP	CENP-a	55355	1058	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|assembly assembly|nmod|nucleosomes nucleosomes|amod|END_ENTITY	Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP .
23638004	0	HJURP	14,19	Holliday_Junction-Recognizing_Protein	21,58	HJURP	Holliday Junction-Recognizing Protein	55355	55355	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Modulation of HJURP -LRB- Holliday_Junction-Recognizing_Protein -RRB- levels is correlated with glioblastoma cells survival .
20065295	0	HJV	18,21	Neogenin	0,8	HJV	Neogenin	69585(Tax:10090)	18007(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis .
24924632	0	HK-2	141,145	HIF-1	71,76	HK-2	HIF-1	3099	3091	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Fatty_acid-bearing albumin but not fatty_acid-depleted albumin induces HIF-1 activation in human renal proximal tubular epithelial cell line HK-2 .
10604382	0	HK2	123,126	glandular_kallikrein_2	99,121	HK2	glandular kallikrein 2	3099	3817	Gene	Gene	Discrimination|appos|START_ENTITY Discrimination|nmod|men men|nmod|prostate_cancer prostate_cancer|nmod|those those|nmod|disease disease|nmod|measurements measurements|nmod|END_ENTITY	Discrimination of men with prostate_cancer from those with benign disease by measurements of human glandular_kallikrein_2 -LRB- HK2 -RRB- in serum .
26884725	0	HK2	47,50	hexokinase_II	32,45	HK2	hexokinase II	3099	3099	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glycolytic enzyme hexokinase_II -LRB- HK2 -RRB- suppresses lung_tumor growth .
15752612	0	HL	56,58	HMG-CoA_lyase	41,54	HL	HMG-CoA lyase	3155	3155	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Skipping of exon 2 and exons 2 plus 3 of HMG-CoA_lyase -LRB- HL -RRB- gene produces the loss of beta sheets 1 and 2 in the recently proposed -LRB- beta-alpha -RRB- 8 TIM barrel model of HL .
2571126	0	HL	52,54	hepatic_lipase	36,50	HL	hepatic lipase	3990	3990	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Xmn-1 and Bg1-II RFLPs at the human hepatic_lipase -LRB- HL -RRB- gene locus .
11086086	0	HLA-A	92,97	CD8	114,117	HLA-A	CD8	3105	925	Gene	Gene	START_ENTITY|dobj|cells cells|compound|END_ENTITY	Identification of major epitopes of Mycobacterium_tuberculosis AG85B that are recognized by HLA-A * 0201-restricted CD8 + T cells in HLA-transgenic_mice and humans .
11477559	0	HLA-A	60,65	CD8	32,35	HLA-A	CD8	3105	925	Gene	Gene	specific|nmod|START_ENTITY peptides|dep|specific T|xcomp|peptides T|nsubj|Detection Detection|nmod|END_ENTITY	Detection and quantification of CD8 -LRB- + -RRB- T cells specific for HLA-A * 0201-binding melanoma and viral peptides by the IFN-gamma-ELISPOT assay .
11485622	0	HLA-A	0,5	CD8	205,208	HLA-A	CD8	3105	925	Gene	Gene	alleles|advmod|START_ENTITY alleles|parataxis|peptide peptide|xcomp|generate generate|dobj|type type|dep|END_ENTITY	HLA-A * 26 , HLA-B * 4002 , HLA-B * 4006 , and HLA-B * 4801 alleles predispose to adult_T_cell_leukemia : the limited recognition of HTLV type 1 tax peptide anchor motifs and epitopes to generate anti-HTLV type 1 tax CD8 -LRB- + -RRB- cytotoxic T lymphocytes .
11535524	0	HLA-A	28,33	CD8	75,78	HLA-A	CD8	3105	925	Gene	Gene	identification|nmod|START_ENTITY END_ENTITY|nsubj|identification	Efficient identification of HLA-A * 2402-restricted cytomegalovirus-specific CD8 -LRB- + -RRB- T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay .
11730845	0	HLA-A	11,16	CD8	80,83	HLA-A	CD8	3105	925	Gene	Gene	use|nmod|START_ENTITY use|nmod|T T|compound|END_ENTITY	The use of HLA-A * 0201-transfected K562 as standard antigen-presenting_cells for CD8 -LRB- + -RRB- T lymphocytes in IFN-gamma ELISPOT assays .
11751984	0	HLA-A	50,55	CD8	26,29	HLA-A	CD8	3105	925	Gene	Gene	responses|nmod|START_ENTITY T|dobj|responses T|nsubj|Generation Generation|nmod|END_ENTITY	Generation of genome-wide CD8 T cell responses in HLA-A * 0201 transgenic_mice by an HIV-1 ubiquitin expression library immunization vaccine .
12668642	0	HLA-A	58,63	CD8	16,19	HLA-A	CD8	3105	925	Gene	Gene	epitopes|compound|START_ENTITY responses|nmod|epitopes responses|compound|END_ENTITY	Quantitation of CD8 + T cell responses to newly identified HLA-A * 0201-restricted T cell epitopes conserved among vaccinia and variola _ -LRB- smallpox -RRB- _ viruses .
15153496	0	HLA-A	160,165	CD8	111,114	HLA-A	CD8	3105	925	Gene	Gene	context|nmod|START_ENTITY recognized|nmod|context recognized|dep|sufficient sufficient|advcl|identifying identifying|dobj|epitopes epitopes|compound|END_ENTITY	Random screening of proteins for HLA-A * 0201-binding nine-amino_acid_peptides is not sufficient for identifying CD8 T cell epitopes recognized in the context of HLA-A * 0201 .
15153496	0	HLA-A	33,38	CD8	111,114	HLA-A	CD8	3105	925	Gene	Gene	proteins|nmod|START_ENTITY screening|nmod|proteins recognized|nsubj|screening recognized|dep|sufficient sufficient|advcl|identifying identifying|dobj|epitopes epitopes|compound|END_ENTITY	Random screening of proteins for HLA-A * 0201-binding nine-amino_acid_peptides is not sufficient for identifying CD8 T cell epitopes recognized in the context of HLA-A * 0201 .
15802306	0	HLA-A	38,43	CD8	0,3	HLA-A	CD8	3105	925	Gene	Gene	specific|nmod|START_ENTITY present|dep|specific T|xcomp|present T|nsubj|+ +|compound|END_ENTITY	CD8 + T cells specific for a potential HLA-A * 0201 epitope from Chlamydophila_pneumoniae are present in the PBMCs from infected patients .
16339578	0	HLA-A	21,26	CD8	0,3	HLA-A	CD8	3105	925	Gene	Gene	*|compound|START_ENTITY cell-mediated|dobj|* cell-mediated|nsubj|T T|compound|END_ENTITY	CD8 + T cell-mediated HLA-A * 0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple_sclerosis .
17911594	0	HLA-A	90,95	CD8	0,3	HLA-A	CD8	3105	925	Gene	Gene	peptides|nmod|START_ENTITY T|nmod|peptides T|nsubj|END_ENTITY	CD8 T cell responses to myelin_oligodendrocyte_glycoprotein-derived peptides in humanized HLA-A * 0201-transgenic_mice .
18097044	0	HLA-A	0,5	CD8	22,25	HLA-A	CD8	3105	925	Gene	Gene	glycoprotein_D|nsubj|START_ENTITY glycoprotein_D|dep|identified identified|nsubj|epitopes epitopes|compound|END_ENTITY	HLA-A * 0201-restricted CD8 + cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein_D .
18753217	0	HLA-A	18,23	CD8	52,55	HLA-A	CD8	3105	925	Gene	Gene	Identification|nmod|START_ENTITY shared|nsubj|Identification shared|dep|epitopes epitopes|nsubj|T-cell T-cell|compound|END_ENTITY	Identification of HLA-A * 01 - and HLA-A * 02-restricted CD8 + T-cell epitopes shared among group B enteroviruses .
19698161	0	HLA-A	18,23	CD8	94,97	HLA-A	CD8	3105	925	Gene	Gene	Identification|nmod|START_ENTITY epitopes|nsubj|Identification epitopes|advcl|lymphocytes lymphocytes|nsubj|targets targets|nmod|T T|compound|END_ENTITY	Identification of HLA-A * 2402-restricted HCMV immediate early-1 -LRB- IE-1 -RRB- epitopes as targets for CD8 + HCMV-specific cytotoxic T lymphocytes .
20123035	0	HLA-A	21,26	CD8	43,46	HLA-A	CD8	3105	925	Gene	Gene	epitope|amod|START_ENTITY epitope|compound|END_ENTITY	Identification of an HLA-A * 0201-restricted CD8 -LRB- + -RRB- T-cell epitope encoded within Leptospiral_immunoglobulin-like_protein_A .
20166182	0	HLA-A	42,47	CD8	64,67	HLA-A	CD8	3105	925	Gene	Gene	START_ENTITY|dep|epitope epitope|dep|END_ENTITY	Identification of a dengue virus-specific HLA-A * 0201-restricted CD8 + T cell epitope .
20488208	0	HLA-A	110,115	CD8	130,133	HLA-A	CD8	3105	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The resistance mutation R155K in the NS3/4A protease of hepatitis_C_virus also leads the virus to escape from HLA-A * 68-restricted CD8 T cells .
20709007	0	HLA-A	24,29	CD8	0,3	HLA-A	CD8	3105	925	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	CD8 + T cell response in HLA-A * 0201 transgenic_mice is elicited by epitopes from SARS-CoV S protein .
21530544	0	HLA-A	37,42	CD8	59,62	HLA-A	CD8	3105	925	Gene	Gene	screening|nmod|START_ENTITY screening|amod|0201-restricted 0201-restricted|dep|END_ENTITY	Knowledge-based virtual screening of HLA-A * 0201-restricted CD8 + T-cell epitope peptides from herpes simplex virus genome .
21745520	0	HLA-A	24,29	CD8	74,77	HLA-A	CD8	3105	925	Gene	Gene	responses|nmod|START_ENTITY restricted|nsubj|responses restricted|dobj|S S|acl:relcl|augmented augmented|nsubjpass|cells cells|compound|END_ENTITY	The immune responses of HLA-A * 0201 restricted SARS-CoV S peptide-specific CD8 T cells are augmented in varying degrees by CpG ODN , PolyI : C and R848 .
22480777	0	HLA-A	18,23	CD8	40,43	HLA-A	CD8	3105	925	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Identification of HLA-A * 0201-restricted CD8 + T-cell epitope C from hepatitis_B virus core protein .
22539795	0	HLA-A	7,12	CD8	139,142	HLA-A	CD8	3105	925	Gene	Gene	*|amod|START_ENTITY nonobese|nmod|* nonobese|ccomp|identify identify|nmod|source source|nmod|epitopes epitopes|compound|END_ENTITY	Beyond HLA-A * 0201 : new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8 + T cell epitopes .
23911395	0	HLA-A	26,31	CD8	81,84	HLA-A	CD8	3105	925	Gene	Gene	Identification|nmod|START_ENTITY restricted|nsubj|Identification restricted|dobj|epitope epitope|compound|END_ENTITY	Identification of a novel HLA-A * 24:02 - restricted adenovirus serotype 11-specific CD8 + T-cell epitope for adoptive immunotherapy .
23997182	0	HLA-A	18,23	CD8	40,43	HLA-A	CD8	3105	925	Gene	Gene	START_ENTITY|xcomp|response response|compound|END_ENTITY	An immunodominant HLA-A * 1101-restricted CD8 + T-cell response targeting hepatitis_B surface antigen in chronic hepatitis_B patients .
24101547	0	HLA-A	13,18	CD8	123,126	HLA-A	CD8	3105	925	Gene	Gene	restricted|nsubj|START_ENTITY restricted|nmod|herpes herpes|acl:relcl|recall recall|dobj|cells cells|compound|END_ENTITY	Asymptomatic HLA-A * 02:01 - restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8 + T cells from seropositive asymptomatic individuals and protect HLA transgenic_mice against ocular_herpes .
25008925	0	HLA-A	43,48	CD8	127,130	HLA-A	CD8	3105	925	Gene	Gene	START_ENTITY|dobj|virus virus|nmod|cells cells|compound|END_ENTITY	Impact of sequence variation in a dominant HLA-A * 02-restricted epitope_in_hepatitis_C virus on priming and cross-reactivity of CD8 + T cells .
27036003	0	HLA-A	30,35	CD8	52,55	HLA-A	CD8	3105	925	Gene	Gene	START_ENTITY|dobj|immunity immunity|compound|END_ENTITY	Molecular basis for universal HLA-A * 0201-restricted CD8 + T-cell immunity against influenza viruses .
27072810	0	HLA-A	18,23	CD8	68,71	HLA-A	CD8	3105	925	Gene	Gene	Identification|nmod|START_ENTITY restricted|nsubj|Identification restricted|dobj|T T|compound|END_ENTITY	Identification of HLA-A * 11:01 - restricted Mycobacterium_tuberculosis CD8 -LRB- + -RRB- T cell epitopes .
2784196	0	HLA-A	38,43	CD8	73,76	HLA-A	CD8	3105	925	Gene	Gene	molecules|amod|START_ENTITY domain|nmod|molecules Polymorphism|nmod|domain affects|nsubj|Polymorphism affects|xcomp|binding binding|nmod|END_ENTITY	Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8 .
16243831	0	HLA-A	28,33	CEA	80,83	HLA-A	CEA	3105	1084	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	More efficient induction of HLA-A * 0201-restricted and carcinoembryonic_antigen -LRB- CEA -RRB- - specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells .
19500317	0	HLA-A	24,29	HLA-A	41,46	HLA-A	HLA-A	3105	3105	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-A * 29 allele , HLA-A * 290102 by sequence-based typing in a Chinese individual .
19500317	0	HLA-A	41,46	HLA-A	24,29	HLA-A	HLA-A	3105	3105	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-A * 29 allele , HLA-A * 290102 by sequence-based typing in a Chinese individual .
26206234	0	HLA-A	32,37	HLA-A	42,47	HLA-A	HLA-A	3105	3105	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Detection of a novel variant of HLA-A * 02 , HLA-A * 02:570 , in a Taiwanese unrelated hematopoietic stem cell donor .
26206234	0	HLA-A	32,37	HLA-A	42,47	HLA-A	HLA-A	3105	3105	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Detection of a novel variant of HLA-A * 02 , HLA-A * 02:570 , in a Taiwanese unrelated hematopoietic stem cell donor .
26206234	0	HLA-A	42,47	HLA-A	32,37	HLA-A	HLA-A	3105	3105	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Detection of a novel variant of HLA-A * 02 , HLA-A * 02:570 , in a Taiwanese unrelated hematopoietic stem cell donor .
26206234	0	HLA-A	42,47	HLA-A	32,37	HLA-A	HLA-A	3105	3105	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Detection of a novel variant of HLA-A * 02 , HLA-A * 02:570 , in a Taiwanese unrelated hematopoietic stem cell donor .
11098929	0	HLA-A	97,102	HLA-B	47,52	HLA-A	HLA-B	3105	3106	Gene	Gene	description|nmod|START_ENTITY alleles|dep|description alleles|amod|END_ENTITY	Diversity is demonstrated in class I HLA-A and HLA-B alleles in Cameroon , Africa : description of HLA-A * 03012 , * 2612 , * 3006 and HLA-B * 1403 , * 4016 , * 4703 .
12144620	0	HLA-A	0,5	HLA-B	75,80	HLA-A	HLA-B	3105	3106	Gene	Gene	START_ENTITY|dep|frequencies frequencies|nmod|END_ENTITY	HLA-A and HLA-B in Kenya , Africa : allele frequencies and identification of HLA-B * 1567 and HLA-B * 4426 .
12651070	0	HLA-A	126,131	HLA-B	22,27	HLA-A	HLA-B	3105	3106	Gene	Gene	START_ENTITY|nsubj|dominance dominance|nmod|END_ENTITY	Relative dominance of HLA-B * 07 restricted CD8 + T-lymphocyte immune responses to human_cytomegalovirus pp65 in persons sharing HLA-A * 02 and HLA-B * 07 alleles .
15014000	0	HLA-A	107,112	HLA-B	115,120	HLA-A	HLA-B	3105	3106	Gene	Gene	assays|appos|START_ENTITY assays|amod|END_ENTITY	Performance characteristics of updated INNO-LiPA assays for molecular typing of human leukocyte antigen A -LRB- HLA-A -RRB- , HLA-B , and HLA-DQB1 alleles .
15853906	0	HLA-A	51,56	HLA-B	63,68	HLA-A	HLA-B	3105	3106	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Identification of three novel HLA class I alleles : HLA-A * 0261 , HLA-B * 1585 and HLA-B * 1587 .
21498667	0	HLA-A	0,5	HLA-B	93,98	HLA-A	HLA-B	3105	3106	Gene	Gene	control|amod|START_ENTITY independent|nsubj|control independent|nmod|disequilibrium disequilibrium|nmod|END_ENTITY	HLA-A * 7401-mediated control of HIV_viremia is independent of its linkage disequilibrium with HLA-B * 5703 .
21732916	0	HLA-A	72,77	HLA-B	6,11	HLA-A	HLA-B	3105	3106	Gene	Gene	sharing|dobj|START_ENTITY found|xcomp|sharing HLA-C|parataxis|found HLA-C|nsubj|END_ENTITY	A new HLA-B * 15 allele , B * 15:220 , found in three individuals sharing the HLA-A * 66:01 , HLA-C * 12:03 and HLADRB1 * 07:01 alleles .
23731569	0	HLA-A	0,5	HLA-B	7,12	HLA-A	HLA-B	3105	3106	Gene	Gene	allele|nsubj|START_ENTITY allele|advmod|END_ENTITY	HLA-A , HLA-B , HLA-DRB1 allele and haplotype frequencies in 6384 umbilical cord blood units and transplantation matching and engraftment statistics in the Zhejiang cord blood bank of China .
25345715	0	HLA-A	4,9	HLA-B	71,76	HLA-A	HLA-B	3105	3106	Gene	Gene	identified|dep|START_ENTITY identified|xcomp|sharing sharing|dobj|END_ENTITY	The HLA-A * 02:481 allele was identified in unrelated Brazilians sharing HLA-B * 15:17 , C * 07:01 P , DRB1 * 13:02 and DQB1 * 06:04 .
26846461	0	HLA-A	0,5	HLA-B	7,12	HLA-A	HLA-B	3105	3106	Gene	Gene	START_ENTITY|appos|allele allele|compound|END_ENTITY	HLA-A , HLA-B , HLA-DRB1 allele and haplotype frequencies of 14 529 Chinese Han bone marrow donors living in Dalian , China .
511160	0	HLA-A	40,45	HLA-B	47,52	HLA-A	HLA-B	3105	3106	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Haplotype analysis of the linkage group HLA-A : HLA-B : Bf in Japanese .
699957	0	HLA-A	14,19	HLA-B	32,37	HLA-A	HLA-B	3105	3106	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|not not|nmod|END_ENTITY	Expression of HLA-A , but not of HLA-B , in mouse-human somatic cell hybrids carrying the region p21 leads to pter of human chromosome 6 .
7698817	0	HLA-A	0,5	HLA-B	81,86	HLA-A	HLA-B	3105	3106	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|survival survival|nmod|END_ENTITY	HLA-A incompatibility associated with enhanced long-term renal graft survival in HLA-B , DR mismatched transplants .
8108881	0	HLA-A	99,104	HLA-B	32,37	HLA-A	HLA-B	3105	3106	Gene	Gene	antigens|amod|START_ENTITY lymphocytes|nmod|antigens naive|nmod|lymphocytes naive|nsubj|lymphocytes lymphocytes|nmod|antigens antigens|amod|END_ENTITY	Cytotoxic T lymphocytes against HLA-B antigens are less naive than cytotoxic T lymphocytes against HLA-A antigens .
16874487	0	HLA-A	56,61	MUC1	78,82	HLA-A	MUC1	3105	4582	Gene	Gene	epitope|amod|START_ENTITY epitope|compound|END_ENTITY	The cytotoxic T cell response to peptide analogs of the HLA-A * 0201-restricted MUC1 signal sequence epitope , M1 .2 .
93282	0	HLA-A	65,70	beta_2-microglobulin	33,53	HLA-A	beta 2-microglobulin	3105	567	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Dissociation and exchange of the beta_2-microglobulin subunit of HLA-A and HLA-B antigens .
17892322	0	HLA-B	70,75	CD8	28,31	HLA-B	CD8	3106	925	Gene	Gene	restricted|nmod|START_ENTITY antigens|xcomp|restricted antigens|nsubj|END_ENTITY	Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B .
17911249	0	HLA-B	82,87	CD8	54,57	HLA-B	CD8	3106	925	Gene	Gene	genotype|amod|START_ENTITY T|nmod|genotype T|nsubj|association association|nmod|END_ENTITY	Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype .
18275350	0	HLA-B	51,56	CD8	15,18	HLA-B	CD8	3106	925	Gene	Gene	presented|nmod|START_ENTITY epitope|acl|presented epitope|compound|END_ENTITY	Targeting of a CD8 T cell env epitope presented by HLA-B * 5802 is associated with markers of HIV_disease_progression and lack of selection pressure .
18945768	0	HLA-B	71,76	CD8	91,94	HLA-B	CD8	3106	925	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Functional consequences of human immunodeficiency virus escape from an HLA-B * 13-restricted CD8 + T-cell epitope in p1 Gag protein .
18945771	0	HLA-B	98,103	CD8	12,15	HLA-B	CD8	3106	925	Gene	Gene	nef|nmod|START_ENTITY pressure|nmod|nef +|dobj|pressure +|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence of CD8 + T-cell-mediated selective pressure on human_immunodeficiency_virus_type_1 nef in HLA-B * 57 + elite suppressors .
20638093	0	HLA-B	30,35	CD8	58,61	HLA-B	CD8	3106	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Immunodominant HIV-1-specific HLA-B - and HLA-C-restricted CD8 + T cells do not differ in polyfunctionality .
22072759	0	HLA-B	23,28	CD8	43,46	HLA-B	CD8	3106	925	Gene	Gene	Escape|nmod|START_ENTITY Escape|dep|requires requires|nsubj|response response|compound|END_ENTITY	Escape from a dominant HLA-B * 15-restricted CD8 + T cell response against hepatitis_C_virus requires compensatory mutations outside the epitope .
22880104	0	HLA-B	56,61	CD8	40,43	HLA-B	CD8	3106	925	Gene	Gene	START_ENTITY|nsubj|elicitation elicitation|nmod|Cells Cells|compound|END_ENTITY	Effective elicitation of human effector CD8 + T Cells in HLA-B * 51:01 transgenic humanized mice after infection with HIV-1 .
23079801	0	HLA-B	20,25	CD8	125,128	HLA-B	CD8	3106	925	Gene	Gene	control|nmod|START_ENTITY control|parataxis|associated associated|nmod|number number|nmod|cells cells|compound|END_ENTITY	Poor HIV control in HLA-B * 27 and B * 57/58 noncontrollers is associated with limited number of polyfunctional Gag p24-specific CD8 + T cells .
23209413	0	HLA-B	77,82	CD8	124,127	HLA-B	CD8	3106	925	Gene	Gene	processing|nmod|START_ENTITY antigen|dobj|processing antigen|dep|epitope epitope|compound|END_ENTITY	Rapid antigen processing and presentation of a protective and immunodominant HLA-B * 27-restricted hepatitis_C virus-specific CD8 + T-cell epitope .
24131719	0	HLA-B	5,10	CD8	71,74	HLA-B	CD8	3106	925	Gene	Gene	levels|amod|START_ENTITY contribute|nsubj|levels contribute|nmod|response response|compound|END_ENTITY	Both HLA-B * 57 and plasma HIV RNA levels contribute to the HIV-specific CD8 + T cell response in HIV controllers .
24330837	0	HLA-B	18,23	CD8	0,3	HLA-B	CD8	3106	925	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	CD8 + T cells from HLA-B * 57 elite suppressors effectively suppress replication of HIV-1 escape mutants .
24349220	0	HLA-B	103,108	CD8	6,9	HLA-B	CD8	3106	925	Gene	Gene	alleles|amod|START_ENTITY restricted|nmod|alleles CFP10|acl|restricted epitopes|nmod|CFP10 respond|nmod|epitopes respond|nsubj|cells cells|compound|END_ENTITY	Human CD8 + T cells from TB_pleurisy respond to four immunodominant epitopes in Mtb CFP10 restricted by HLA-B alleles .
25243920	0	HLA-B	91,96	CD8	119,122	HLA-B	CD8	3106	925	Gene	Gene	START_ENTITY|ccomp|restricted restricted|xcomp|END_ENTITY	Human_herpesvirus_6B immediate-early I protein contains functional HLA-A * 02 , HLA-A * 03 , and HLA-B * 07 class I restricted CD8 -LRB- + -RRB- T-cell epitopes .
26372480	0	HLA-B	74,79	CD8	97,100	HLA-B	CD8	3106	925	Gene	Gene	eliminates|dobj|START_ENTITY eliminates|dep|activation activation|compound|END_ENTITY	Towards depersonalized abacavir therapy : chemical modification eliminates HLA-B * 57:01 - restricted CD8 + T-cell activation .
9710228	0	HLA-B	108,113	CD8	191,194	HLA-B	CD8	3106	925	Gene	Gene	differentiating|dobj|START_ENTITY His116|acl|differentiating influences|nsubj|His116 influences|dobj|recognition recognition|amod|peptide-specific peptide-specific|dep|END_ENTITY	The naturally occurring polymorphism Asp116 -- > His116 , differentiating the ankylosing_spondylitis-associated HLA-B * 2705 from the non-associated HLA-B * 2709 subtype , influences peptide-specific CD8 T cell recognition .
9710228	0	HLA-B	143,148	CD8	191,194	HLA-B	CD8	3106	925	Gene	Gene	HLA-B|nmod|START_ENTITY differentiating|dobj|HLA-B His116|acl|differentiating influences|nsubj|His116 influences|dobj|recognition recognition|amod|peptide-specific peptide-specific|dep|END_ENTITY	The naturally occurring polymorphism Asp116 -- > His116 , differentiating the ankylosing_spondylitis-associated HLA-B * 2705 from the non-associated HLA-B * 2709 subtype , influences peptide-specific CD8 T cell recognition .
10519372	0	HLA-B	79,84	DRB1	91,95	HLA-B	DRB1	3106	3125	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	HLA-Cw * 1701 is associated with two sub-Saharan African-derived HLA haplotypes : HLA-B * 4201 , DRB1 * 03 and HLA-B * 4202 without DRB1 * 03 .
18945768	0	HLA-B	71,76	Gag	117,120	HLA-B	Gag	3106	155030(Tax:11676)	Gene	Gene	T-cell|compound|START_ENTITY escape|nmod|T-cell consequences|nmod|escape epitope|nsubj|consequences epitope|nmod|protein protein|compound|END_ENTITY	Functional consequences of human immunodeficiency virus escape from an HLA-B * 13-restricted CD8 + T-cell epitope in p1 Gag protein .
11098929	0	HLA-B	47,52	HLA-A	97,102	HLA-B	HLA-A	3106	3105	Gene	Gene	alleles|amod|START_ENTITY alleles|dep|description description|nmod|END_ENTITY	Diversity is demonstrated in class I HLA-A and HLA-B alleles in Cameroon , Africa : description of HLA-A * 03012 , * 2612 , * 3006 and HLA-B * 1403 , * 4016 , * 4703 .
12144620	0	HLA-B	75,80	HLA-A	0,5	HLA-B	HLA-A	3106	3105	Gene	Gene	frequencies|nmod|START_ENTITY END_ENTITY|dep|frequencies	HLA-A and HLA-B in Kenya , Africa : allele frequencies and identification of HLA-B * 1567 and HLA-B * 4426 .
12651070	0	HLA-B	22,27	HLA-A	126,131	HLA-B	HLA-A	3106	3105	Gene	Gene	dominance|nmod|START_ENTITY END_ENTITY|nsubj|dominance	Relative dominance of HLA-B * 07 restricted CD8 + T-lymphocyte immune responses to human_cytomegalovirus pp65 in persons sharing HLA-A * 02 and HLA-B * 07 alleles .
15014000	0	HLA-B	115,120	HLA-A	107,112	HLA-B	HLA-A	3106	3105	Gene	Gene	assays|amod|START_ENTITY assays|appos|END_ENTITY	Performance characteristics of updated INNO-LiPA assays for molecular typing of human leukocyte antigen A -LRB- HLA-A -RRB- , HLA-B , and HLA-DQB1 alleles .
15853906	0	HLA-B	63,68	HLA-A	51,56	HLA-B	HLA-A	3106	3105	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Identification of three novel HLA class I alleles : HLA-A * 0261 , HLA-B * 1585 and HLA-B * 1587 .
21498667	0	HLA-B	93,98	HLA-A	0,5	HLA-B	HLA-A	3106	3105	Gene	Gene	disequilibrium|nmod|START_ENTITY independent|nmod|disequilibrium independent|nsubj|control control|amod|END_ENTITY	HLA-A * 7401-mediated control of HIV_viremia is independent of its linkage disequilibrium with HLA-B * 5703 .
21732916	0	HLA-B	6,11	HLA-A	72,77	HLA-B	HLA-A	3106	3105	Gene	Gene	HLA-C|nsubj|START_ENTITY HLA-C|parataxis|found found|xcomp|sharing sharing|dobj|END_ENTITY	A new HLA-B * 15 allele , B * 15:220 , found in three individuals sharing the HLA-A * 66:01 , HLA-C * 12:03 and HLADRB1 * 07:01 alleles .
23731569	0	HLA-B	7,12	HLA-A	0,5	HLA-B	HLA-A	3106	3105	Gene	Gene	allele|advmod|START_ENTITY allele|nsubj|END_ENTITY	HLA-A , HLA-B , HLA-DRB1 allele and haplotype frequencies in 6384 umbilical cord blood units and transplantation matching and engraftment statistics in the Zhejiang cord blood bank of China .
25345715	0	HLA-B	71,76	HLA-A	4,9	HLA-B	HLA-A	3106	3105	Gene	Gene	sharing|dobj|START_ENTITY identified|xcomp|sharing identified|dep|END_ENTITY	The HLA-A * 02:481 allele was identified in unrelated Brazilians sharing HLA-B * 15:17 , C * 07:01 P , DRB1 * 13:02 and DQB1 * 06:04 .
26846461	0	HLA-B	7,12	HLA-A	0,5	HLA-B	HLA-A	3106	3105	Gene	Gene	allele|compound|START_ENTITY END_ENTITY|appos|allele	HLA-A , HLA-B , HLA-DRB1 allele and haplotype frequencies of 14 529 Chinese Han bone marrow donors living in Dalian , China .
511160	0	HLA-B	47,52	HLA-A	40,45	HLA-B	HLA-A	3106	3105	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Haplotype analysis of the linkage group HLA-A : HLA-B : Bf in Japanese .
699957	0	HLA-B	32,37	HLA-A	14,19	HLA-B	HLA-A	3106	3105	Gene	Gene	not|nmod|START_ENTITY Expression|dep|not Expression|nmod|END_ENTITY	Expression of HLA-A , but not of HLA-B , in mouse-human somatic cell hybrids carrying the region p21 leads to pter of human chromosome 6 .
7698817	0	HLA-B	81,86	HLA-A	0,5	HLA-B	HLA-A	3106	3105	Gene	Gene	survival|nmod|START_ENTITY associated|nmod|survival associated|nsubj|END_ENTITY	HLA-A incompatibility associated with enhanced long-term renal graft survival in HLA-B , DR mismatched transplants .
8108881	0	HLA-B	32,37	HLA-A	99,104	HLA-B	HLA-A	3106	3105	Gene	Gene	antigens|amod|START_ENTITY lymphocytes|nmod|antigens naive|nsubj|lymphocytes naive|nmod|lymphocytes lymphocytes|nmod|antigens antigens|amod|END_ENTITY	Cytotoxic T lymphocytes against HLA-B antigens are less naive than cytotoxic T lymphocytes against HLA-A antigens .
11019922	0	HLA-B	24,29	HLA-B	41,46	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-B * 39 allele : HLA-B * 3924 .
11019922	0	HLA-B	41,46	HLA-B	24,29	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-B * 39 allele : HLA-B * 3924 .
11972884	0	HLA-B	26,31	HLA-B	43,48	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a novel HLA-B * 07 allele -- HLA-B * 0726 .
11972884	0	HLA-B	43,48	HLA-B	26,31	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a novel HLA-B * 07 allele -- HLA-B * 0726 .
12028547	0	HLA-B	24,29	HLA-B	41,46	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-B * 15 allele , HLA-B * 1569 .
12028547	0	HLA-B	41,46	HLA-B	24,29	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-B * 15 allele , HLA-B * 1569 .
15361131	0	HLA-B	51,56	HLA-B	63,68	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Identification of three novel HLA class I alleles : HLA-B * 3928 , HLA-B * 400104 and HLA-B * 4437 .
15361131	0	HLA-B	63,68	HLA-B	51,56	HLA-B	HLA-B	3106	3106	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Identification of three novel HLA class I alleles : HLA-B * 3928 , HLA-B * 400104 and HLA-B * 4437 .
19140837	0	HLA-B	24,29	HLA-B	41,46	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-B * 40 allele , HLA-B * 4081 , in a Chinese individual .
19140837	0	HLA-B	41,46	HLA-B	24,29	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-B * 40 allele , HLA-B * 4081 , in a Chinese individual .
22092085	0	HLA-B	42,47	HLA-B	58,63	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Characterization of four new HLA alleles : HLA-B * 15:01:18 , HLA-B * 44:110 , HLA-C * 04:01:22 and HLA-DQB_1 * 05:14 .
22092085	0	HLA-B	58,63	HLA-B	42,47	HLA-B	HLA-B	3106	3106	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Characterization of four new HLA alleles : HLA-B * 15:01:18 , HLA-B * 44:110 , HLA-C * 04:01:22 and HLA-DQB_1 * 05:14 .
22469255	0	HLA-B	19,24	HLA-B	36,41	HLA-B	HLA-B	3106	3106	Gene	Gene	Detection|nmod|START_ENTITY END_ENTITY|nsubj|Detection	Detection of a new HLA-B * 15 allele , HLA-B * 15:238 , in a voluntary stem cell donor .
22469255	0	HLA-B	36,41	HLA-B	19,24	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Detection Detection|nmod|END_ENTITY	Detection of a new HLA-B * 15 allele , HLA-B * 15:238 , in a voluntary stem cell donor .
23216290	0	HLA-B	24,29	HLA-B	41,46	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-B * 13 allele , HLA-B * 13:23 .
23216290	0	HLA-B	41,46	HLA-B	24,29	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-B * 13 allele , HLA-B * 13:23 .
25346417	0	HLA-B	24,29	HLA-B	41,46	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-B * 57 allele , HLA-B * 57:71 , by next-generation sequencing .
25346417	0	HLA-B	41,46	HLA-B	24,29	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-B * 57 allele , HLA-B * 57:71 , by next-generation sequencing .
26198648	0	HLA-B	32,37	HLA-B	42,47	HLA-B	HLA-B	3106	3106	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Detection of a novel variant of HLA-B * 07 , HLA-B * 07:249 , in a Taiwanese unrelated hematopoietic stem cell donor .
26198648	0	HLA-B	42,47	HLA-B	32,37	HLA-B	HLA-B	3106	3106	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Detection of a novel variant of HLA-B * 07 , HLA-B * 07:249 , in a Taiwanese unrelated hematopoietic stem cell donor .
26889906	0	HLA-B	26,31	HLA-B	43,48	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a novel HLA-B * 40 allele , HLA-B * 40:324 , by sequence-based typing , in a Chinese individual .
26889906	0	HLA-B	43,48	HLA-B	26,31	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a novel HLA-B * 40 allele , HLA-B * 40:324 , by sequence-based typing , in a Chinese individual .
9098933	0	HLA-B	24,29	HLA-B	42,47	HLA-B	HLA-B	3106	3106	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-B * 08 variant , HLA-B * 0804 .
9098933	0	HLA-B	42,47	HLA-B	24,29	HLA-B	HLA-B	3106	3106	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new HLA-B * 08 variant , HLA-B * 0804 .
23731569	0	HLA-B	7,12	HLA-DRB1	14,22	HLA-B	HLA-DRB1	3106	3123	Gene	Gene	allele|advmod|START_ENTITY allele|nsubj|END_ENTITY	HLA-A , HLA-B , HLA-DRB1 allele and haplotype frequencies in 6384 umbilical cord blood units and transplantation matching and engraftment statistics in the Zhejiang cord blood bank of China .
19895570	0	HLA-B	39,44	MICA	0,4	HLA-B	MICA	3106	100507436	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans .
26787826	0	HLA-B	23,28	Nef	76,79	HLA-B	Nef	3106	156110(Tax:11676)	Gene	Gene	START_ENTITY|nmod|Sequences Sequences|compound|END_ENTITY	Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences .
8206526	0	HLA-B	31,36	c-Myc	51,56	HLA-B	c-Myc	3106	4609	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcriptional suppression of HLA-B expression by c-Myc is mediated through the core promoter elements .
9839551	0	HLA-B	26,31	c-myc	44,49	HLA-B	c-myc	3106	4609	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Repression of the minimal HLA-B promoter by c-myc and p53 occurs through independent mechanisms .
18275350	0	HLA-B	51,56	env	26,29	HLA-B	env	3106	100616444	Gene	Gene	presented|nmod|START_ENTITY epitope|acl|presented epitope|compound|END_ENTITY	Targeting of a CD8 T cell env epitope presented by HLA-B * 5802 is associated with markers of HIV_disease_progression and lack of selection pressure .
21059238	0	HLA-B	35,40	nef	23,26	HLA-B	nef	3106	6285	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Evolution of the HIV-1 nef gene in HLA-B * 57 positive elite suppressors .
11207664	0	HLA-B27	105,112	CD4	0,3	HLA-B27	CD4	3106	920	Gene	Gene	study|nmod|START_ENTITY +|nsubj|study indicate|parataxis|+ indicate|nsubj|+ +|compound|END_ENTITY	CD4 + and CD8 + clonal T cell expansions indicate a role of antigens in ankylosing_spondylitis ; a study in HLA-B27 + monozygotic twins .
11509603	0	HLA-B27	19,26	CD4	36,39	HLA-B27	CD4	3106	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	The recognition of HLA-B27 by human CD4 -LRB- + -RRB- T lymphocytes .
12626789	0	HLA-B27	54,61	CD4	65,68	HLA-B27	CD4	3106	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Breaking the rules : the unconventional recognition of HLA-B27 by CD4 + T lymphocytes as an insight into the pathogenesis of the spondyloarthropathies .
16476051	0	HLA-B27	60,67	CD4	35,38	HLA-B27	CD4	3106	24932(Tax:10116)	Gene	Gene	transgenic|amod|START_ENTITY rats|amod|transgenic responses|nmod|rats responses|compound|END_ENTITY	Luminal bacterial antigen-specific CD4 + T-cell responses in HLA-B27 transgenic rats with chronic_colitis are mediated by both major histocompatibility class II and HLA-B27 molecules .
26321090	0	HLA-B27	25,32	KIR3DL1	0,7	HLA-B27	KIR3DL1	3106	3811	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	KIR3DL1 interaction with HLA-B27 is altered by ankylosing_spondylitis associated ERAP1 and enhanced by MHC class I cross-linking .
11685454	0	HLA-B27	126,133	beta2-microglobulin	134,153	HLA-B27	beta2-microglobulin	3106	567	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27 / beta2-microglobulin complex .
11163075	0	HLA-B27	22,29	beta_2-microglobulin	47,67	HLA-B27	beta 2-microglobulin	3106	567	Gene	Gene	chain|compound|START_ENTITY association|nmod|chain association|nmod|END_ENTITY	Strong association of HLA-B27 heavy chain with beta_2-microglobulin .
2259876	0	HLA-B27	40,47	beta_2-microglobulin	16,36	HLA-B27	beta 2-microglobulin	3106	567	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Serum levels of beta_2-microglobulin in HLA-B27 + patients with acute_anterior_uveitis and ankylosing_spondylitis .
7561688	0	HLA-B27	38,45	beta_2-microglobulin	70,90	HLA-B27	beta 2-microglobulin	3106	12010(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|acl|lacking lacking|xcomp|END_ENTITY	Spontaneous inflammatory_arthritis in HLA-B27 transgenic_mice lacking beta_2-microglobulin : a model of human spondyloarthropathies .
8835498	0	HLA-B27	97,104	beta_2-microglobulin	21,41	HLA-B27	beta 2-microglobulin	3106	567	Gene	Gene	transgenic_mice|compound|START_ENTITY ankylosing_enthesopathy|nmod|transgenic_mice occurrence|nmod|ankylosing_enthesopathy increases|dobj|occurrence increases|nsubj|absence absence|nmod|END_ENTITY	The absence of human beta_2-microglobulin increases the occurrence of ankylosing_enthesopathy in HLA-B27 transgenic_mice .
9246711	0	HLA-B27	48,55	beta_2-microglobulin	56,76	HLA-B27	beta 2-microglobulin	3106	24223(Tax:10116)	Gene	Gene	inflammation|nmod|START_ENTITY /|nsubj|inflammation /|dobj|rats rats|amod|END_ENTITY	Intestinal inflammation and barrier function in HLA-B27 / beta_2-microglobulin transgenic rats .
9681392	0	HLA-B27	96,103	interleukin-10	30,44	HLA-B27	interleukin-10	3106	16153(Tax:10090)	Gene	Gene	transgenic|nmod|START_ENTITY Effects|amod|transgenic Effects|nmod|END_ENTITY	Effects of murine recombinant interleukin-10 on the inflammatory_disease of rats transgenic for HLA-B27 and human beta_2-microglobulin .
26239392	0	HLA-C	25,30	HLA-C	41,46	HLA-C	HLA-C	3107	3107	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Three new HLA-C alleles -LRB- HLA-C * 14:02:13 , HLA-C * 15:72 and HLA-C * 15:74 -RRB- in Saudi bone marrow donors .
26239392	0	HLA-C	41,46	HLA-C	25,30	HLA-C	HLA-C	3107	3107	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Three new HLA-C alleles -LRB- HLA-C * 14:02:13 , HLA-C * 15:72 and HLA-C * 15:74 -RRB- in Saudi bone marrow donors .
12823445	0	HLA-C	15,20	SPR1	0,4	HLA-C	SPR1	3107	170680	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene .
21542807	0	HLA-C	85,90	killer_cell_immunoglobulin-like_receptor	16,56	HLA-C	killer cell immunoglobulin-like receptor	3107	3806	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Distribution of killer_cell_immunoglobulin-like_receptor genes and combinations with HLA-C ligands in an isolated Han population in southwest China .
2323107	0	HLA-DP	0,6	interleukin-2	30,43	HLA-DP	interleukin-2	3115	3558	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nsubj|cells	HLA-DP + T cells and deficient interleukin-2 production in patients with systemic_lupus_erythematosus .
14975942	0	HLA-DP	88,94	tumor_necrosis_factor-alpha	18,45	HLA-DP	tumor necrosis factor-alpha	3115	7124	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|production production|amod|END_ENTITY	Beryllium-induced tumor_necrosis_factor-alpha production by CD4 + T cells is mediated by HLA-DP .
20350610	0	HLA-DPB1	0,8	CD4	89,92	HLA-DPB1	CD4	3115	920	Gene	Gene	START_ENTITY|acl|mismatching mismatching|advcl|showing showing|nsubj|generation generation|nmod|repertoire repertoire|nmod|responses responses|compound|END_ENTITY	HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4 + T cell responses showing immunogenicity of all HLA-DPB1 alleles .
20350610	0	HLA-DPB1	141,149	CD4	89,92	HLA-DPB1	CD4	3115	920	Gene	Gene	immunogenicity|nmod|START_ENTITY showing|dobj|immunogenicity showing|nsubj|generation generation|nmod|repertoire repertoire|nmod|responses responses|compound|END_ENTITY	HLA-DPB1 mismatching results in the generation of a full repertoire of HLA-DPB1-specific CD4 + T cell responses showing immunogenicity of all HLA-DPB1 alleles .
21760531	0	HLA-DPB1	21,29	CD4	83,86	HLA-DPB1	CD4	3115	920	Gene	Gene	START_ENTITY|ccomp|recognized recognized|nmod|T T|compound|END_ENTITY	Identification of an HLA-DPB1 * 0501 restricted Melan-A/MART -1 epitope recognized by CD4 + T lymphocytes : prevalence for immunotherapy in Asian populations .
23502763	0	HLA-DPB1	0,8	CD4	58,61	HLA-DPB1	CD4	3115	920	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	HLA-DPB1 * 05 : 01-restricted WT1332-specific TCR-transduced CD4 + T lymphocytes display a helper activity for WT1-specific CTL induction and a cytotoxicity against leukemia cells .
8847233	0	HLA-DPB1	28,36	HLA-DRB1	15,23	HLA-DPB1	HLA-DRB1	3115	3123	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association to HLA-DRB1 * 08 , HLA-DPB1 * 0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing_spondylitis .
3610256	0	HLA-DQ_alpha	28,40	DX_alpha	46,54	HLA-DQ alpha	DX alpha	3117	3118	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Structure and expression of HLA-DQ_alpha and - DX_alpha genes : interallelic alternate splicing of the HLA-DQ_alpha gene and functional splicing of the HLA-DQ_alpha gene using a retroviral vector .
3610256	0	HLA-DQ_alpha	101,113	HLA-DQ_alpha	150,162	HLA-DQ alpha	HLA-DQ alpha	3117	3117	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	Structure and expression of HLA-DQ_alpha and - DX_alpha genes : interallelic alternate splicing of the HLA-DQ_alpha gene and functional splicing of the HLA-DQ_alpha gene using a retroviral vector .
3610256	0	HLA-DQ_alpha	150,162	HLA-DQ_alpha	101,113	HLA-DQ alpha	HLA-DQ alpha	3117	3117	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	Structure and expression of HLA-DQ_alpha and - DX_alpha genes : interallelic alternate splicing of the HLA-DQ_alpha gene and functional splicing of the HLA-DQ_alpha gene using a retroviral vector .
12166499	0	HLA-DRB1	99,107	CCR5	114,118	HLA-DRB1	CCR5	3123	1234	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Disease severity in Danish multiple_sclerosis patients evaluated by MRI and three genetic markers -LRB- HLA-DRB1 * 1501 , CCR5 deletion mutation , apolipoprotein_E -RRB- .
12144622	0	HLA-DRB1	22,30	DQA1	32,36	HLA-DRB1	DQA1	3123	3117	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Molecular analysis of HLA-DRB1 , DQA1 , DQB1 , DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico .
8851725	0	HLA-DRB1	0,8	DQA1	10,14	HLA-DRB1	DQA1	3123	3117	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	HLA-DRB1 , DQA1 , DQB1 DNA polymorphism in the Bulgarian population .
10200357	0	HLA-DRB1	17,25	DQB1	27,31	HLA-DRB1	DQB1	3123	3119	Gene	Gene	Polymorphism|nmod|START_ENTITY END_ENTITY|nsubj|Polymorphism	-LSB- Polymorphism of HLA-DRB1 , DQB1 in the Hans of north China -RSB- OBJECTIVE : To understand polymorphism of HLA-DRB1 , DQB1 in the Hans of north China and obtain more comprehensive and accurate data on genetics at DNA level .
10331158	0	HLA-DRB1	17,25	DQB1	26,30	HLA-DRB1	DQB1	3123	3119	Gene	Gene	Distributions|nmod|START_ENTITY Distributions|dep|alleles alleles|nummod|END_ENTITY	Distributions of HLA-DRB1 / DQB1 alleles and haplotypes in the north-eastern Thai population : indicative of a distinct Thai population with Chinese admixtures in the central Thais .
12144622	0	HLA-DRB1	22,30	DQB1	38,42	HLA-DRB1	DQB1	3123	3119	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Molecular analysis of HLA-DRB1 , DQA1 , DQB1 , DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico .
12823769	0	HLA-DRB1	0,8	DQB1	12,16	HLA-DRB1	DQB1	3123	3119	Gene	Gene	*|compound|START_ENTITY *|dep|* *|compound|END_ENTITY	HLA-DRB1 * , - DQB1 * in Piramalai Kallars and Yadhavas , two Dravidian-speaking castes of Tamil Nadu , South India .
15985473	0	HLA-DRB1	26,34	DQB1	35,39	HLA-DRB1	DQB1	3123	3119	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|parataxis|alleles alleles|nsubj|END_ENTITY	Contribution of selective HLA-DRB1 / DQB1 alleles and haplotypes to the genetic susceptibility of type_1_diabetes among Lebanese and Bahraini Arabs .
16573562	0	HLA-DRB1	0,8	DQB1	11,15	HLA-DRB1	DQB1	3123	3119	Gene	Gene	alleles|ccomp|START_ENTITY alleles|nsubj|END_ENTITY	HLA-DRB1 , - DQB1 alleles in head_and_neck_carcinoma patients .
17047287	0	HLA-DRB1	74,82	DQB1	84,88	HLA-DRB1	DQB1	3123	3119	Gene	Gene	START_ENTITY|appos|alleles alleles|nummod|END_ENTITY	Is the association between TNF-alpha-308 A allele and DMT1 independent of HLA-DRB1 , DQB1 alleles ?
17389015	0	HLA-DRB1	0,8	DQB1	33,37	HLA-DRB1	DQB1	3123	3119	Gene	Gene	*|nsubj|START_ENTITY *|nmod|END_ENTITY	HLA-DRB1 * 0402 haplotypes without DQB1 * 0302 in Venezuelan patients with pemphigus_vulgaris .
17531857	0	HLA-DRB1	0,8	DQB1	28,32	HLA-DRB1	DQB1	3123	3119	Gene	Gene	START_ENTITY|acl:relcl|DQB1 DQB1|ccomp|END_ENTITY	HLA-DRB1 * 1501 , - DQB1 * 0301 , - DQB1 * 0302 , - DQB1 * 0602 , and - DQB1 * 0603 alleles are associated with more severe disease outcome on MRI in patients with multiple_sclerosis .
17531857	0	HLA-DRB1	0,8	DQB1	40,44	HLA-DRB1	DQB1	3123	3119	Gene	Gene	START_ENTITY|acl:relcl|DQB1 DQB1|ccomp|DQB1 DQB1|ccomp|END_ENTITY	HLA-DRB1 * 1501 , - DQB1 * 0301 , - DQB1 * 0302 , - DQB1 * 0602 , and - DQB1 * 0603 alleles are associated with more severe disease outcome on MRI in patients with multiple_sclerosis .
19005023	0	HLA-DRB1	33,41	DQB1	42,46	HLA-DRB1	DQB1	3123	3119	Gene	Gene	Influence|nmod|START_ENTITY Influence|dep|haplotypes haplotypes|nummod|END_ENTITY	Influence of common and specific HLA-DRB1 / DQB1 haplotypes on genetic susceptibilities of three distinct Arab populations to type_1_diabetes .
21091360	0	HLA-DRB1	27,35	DQB1	38,42	HLA-DRB1	DQB1	3123	3119	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|polymorphism polymorphism|compound|END_ENTITY	Association analysis about HLA-DRB1 , - DQB1 polymorphism and auto-antibodies against a -LRB- 1 -RRB- - adrenergic receptors in Chinese patients with essential hypertension .
21652028	0	HLA-DRB1	0,8	DQB1	9,13	HLA-DRB1	DQB1	3123	3119	Gene	Gene	START_ENTITY|appos|susceptibility susceptibility|nsubj|END_ENTITY	HLA-DRB1 / DQB1 susceptibility for autoimmune_polyglandular_syndrome_type_II and III in south of Tunisia .
24055898	0	HLA-DRB1	64,72	DQB1	79,83	HLA-DRB1	DQB1	3123	3119	Gene	Gene	conferred|nmod|START_ENTITY conferred|ccomp|END_ENTITY	The HLA-B * 39 allele increases type 1 diabetes risk conferred by HLA-DRB1 * 04:04 - DQB1 * 03:02 and HLA-DRB1 * 08-DQB1 * 04 class II haplotypes .
25636575	0	HLA-DRB1	17,25	DQB1	37,41	HLA-DRB1	DQB1	3123	3119	Gene	Gene	START_ENTITY|appos|-LRB- -LRB-|compound|END_ENTITY	A rare ancestral HLA-DRB1 -LRB- -RRB- 15:01 DQB1 -LRB- -RRB- 02:01 haplotype and its reversion in the same Western European family .
27056075	0	HLA-DRB1	11,19	DQB1	20,24	HLA-DRB1	DQB1	3123	3119	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|Variants Variants|compound|END_ENTITY	Effects of HLA-DRB1 / DQB1 Genetic Variants on Neuroimaging in Healthy , Mild Cognitive_Impairment , and Alzheimer 's _ Disease Cohorts .
7495781	0	HLA-DRB1	0,8	DQB1	108,112	HLA-DRB1	DQB1	3123	3119	Gene	Gene	0401|compound|START_ENTITY associated|nsubjpass|0401 associated|nmod|insulin-dependent_diabetes_mellitus insulin-dependent_diabetes_mellitus|nmod|locus locus|nummod|END_ENTITY	HLA-DRB1 * 0401 is associated with susceptibility to insulin-dependent_diabetes_mellitus independently of the DQB1 locus .
8026985	0	HLA-DRB1	28,36	DQB1	45,49	HLA-DRB1	DQB1	3123	3119	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	Complete association of the HLA-DRB1 * 04 and - DQB1 * 04 alleles with Vogt-Koyanagi-Harada 's _ disease .
8496614	0	HLA-DRB1	72,80	DQB1	102,106	HLA-DRB1	DQB1	3123	3119	Gene	Gene	reveals|nmod|START_ENTITY reveals|parataxis|extended extended|nsubj|0303 0303|compound|END_ENTITY	Oligonucleotide typing reveals association of type_I_psoriasis with the HLA-DRB1 * 0701/2 , - DQA1 * 0201 , - DQB1 * 0303 extended haplotype .
8851725	0	HLA-DRB1	0,8	DQB1	16,20	HLA-DRB1	DQB1	3123	3119	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	HLA-DRB1 , DQA1 , DQB1 DNA polymorphism in the Bulgarian population .
10958361	0	HLA-DRB1	34,42	DRB1	49,53	HLA-DRB1	DRB1	3123	3123	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Identification of two new alleles HLA-DRB1 * 0312 , DRB1 * 0432 and of a DRB3-negative DRB1 * 1313-positive haplotype .
11169267	0	HLA-DRB1	0,8	DRB1	13,17	HLA-DRB1	DRB1	3123	3123	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	HLA-DRB1 * 03 , DRB1 * 11 or DRB1 * 12 and their respective DRB3 specificities in clinical variants of sarcoidosis .
15719619	0	HLA-DRB1	21,29	DRB1	36,40	HLA-DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Relationship between HLA-DRB1 * 0101 , DRB1 * 0301 alleles and interleukin-12 in haemophilic patients and hepatitis_C_virus_positive_hepatocellular_carcinoma patients .
17284220	0	HLA-DRB1	28,36	DRB1	48,52	HLA-DRB1	DRB1	3123	3123	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of a novel HLA-DRB1 * 04 allele -LRB- DRB1 * 0460 -RRB- in the Italian population .
21299540	0	HLA-DRB1	47,55	DRB1	63,67	HLA-DRB1	DRB1	3123	3123	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
21299540	0	HLA-DRB1	47,55	DRB1	75,79	HLA-DRB1	DRB1	3123	3123	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Identification of nine novel HLA-DRB1 alleles , HLA-DRB1 * 04:91 , DRB1 * 07:18 , DRB1 * 11:01:12 , DRB1 * 12:02:05 , DRB1 * 12:22 , DRB1 * 12:23 , DRB1 * 13:100 , DRB1 * 15:45 , and DRB1 * 15:46 by polymerase chain reaction -- sequence-based typing .
22803809	0	HLA-DRB1	24,32	DRB1	46,50	HLA-DRB1	DRB1	3123	3123	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new HLA-DRB1 * 16 variant , DRB1 * 16:19 by sequence-based typing in a Chinese Han .
26467900	0	HLA-DRB1	8,16	DRB1	25,29	HLA-DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|dep|END_ENTITY	A novel HLA-DRB1 allele , DRB1 * 16:36 identified in a Chinese individual from the Xinjiang region .
26812063	0	HLA-DRB1	8,16	DRB1	25,29	HLA-DRB1	DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|dep|END_ENTITY	A novel HLA-DRB1 allele , DRB1 * 15:66:02 was identified in a Chinese potential donor by sequence-based typing .
22394599	0	HLA-DRB1	143,151	FVIII	109,114	HLA-DRB1	FVIII	3123	2157	Gene	Gene	applied|nmod|START_ENTITY applied|dobj|END_ENTITY	CD4 + T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1 * 1501 mice .
23731569	0	HLA-DRB1	14,22	HLA-B	7,12	HLA-DRB1	HLA-B	3123	3106	Gene	Gene	allele|nsubj|START_ENTITY allele|advmod|END_ENTITY	HLA-A , HLA-B , HLA-DRB1 allele and haplotype frequencies in 6384 umbilical cord blood units and transplantation matching and engraftment statistics in the Zhejiang cord blood bank of China .
8847233	0	HLA-DRB1	15,23	HLA-DPB1	28,36	HLA-DRB1	HLA-DPB1	3123	3115	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association to HLA-DRB1 * 08 , HLA-DPB1 * 0301 and homozygosity for an HLA-linked proteasome gene in juvenile ankylosing_spondylitis .
8877401	0	HLA-DRB1	26,34	HLA-DRB1	56,64	HLA-DRB1	HLA-DRB1	3123	3123	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Allogeneic recognition of HLA-DRB1 * 0406 by T cells with HLA-DRB1 * 0403 : role of amino_acid residue 37 on the beta sheet in T cell recognition .
8877401	0	HLA-DRB1	56,64	HLA-DRB1	26,34	HLA-DRB1	HLA-DRB1	3123	3123	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Allogeneic recognition of HLA-DRB1 * 0406 by T cells with HLA-DRB1 * 0403 : role of amino_acid residue 37 on the beta sheet in T cell recognition .
20018001	0	HLA-DRB1	66,74	KCNB1	15,20	HLA-DRB1	KCNB1	3123	3745	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of KCNB1 to rheumatoid_arthritis via interaction with HLA-DRB1 .
10233671	0	HLA-DRB1	105,113	MIF	90,93	HLA-DRB1	MIF	3123	4282	Gene	Gene	peptide|nmod|START_ENTITY peptide|compound|END_ENTITY	Human B cells secrete migration_inhibition_factor -LRB- MIF -RRB- and present a naturally processed MIF peptide on HLA-DRB1 * 0405 by a FXXL motif .
12415586	0	HLA-DRB1	80,88	TNF	89,92	HLA-DRB1	TNF	3123	7124	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Nodular_disease in rheumatoid_arthritis : association with cigarette smoking and HLA-DRB1 / TNF gene interaction .
24696164	0	HLA-DRB1	153,161	Tumor_necrosis_factor_beta	0,26	HLA-DRB1	Tumor necrosis factor beta	3123	4049	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Tumor_necrosis_factor_beta -LRB- TNF-b -RRB- NcoI polymorphism is associated with multiple_sclerosis in Caucasian patients from Southern Brazil independently from HLA-DRB1 .
12166499	0	HLA-DRB1	99,107	apolipoprotein_E	138,154	HLA-DRB1	apolipoprotein E	3123	348	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Disease severity in Danish multiple_sclerosis patients evaluated by MRI and three genetic markers -LRB- HLA-DRB1 * 1501 , CCR5 deletion mutation , apolipoprotein_E -RRB- .
7910161	0	HLA-DRB3	20,28	Bet	73,76	HLA-DRB3	Bet	3125	92737	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association between HLA-DRB3 * 0101 and immunoglobulin-E responsiveness to Bet v I .
10996380	0	HLA-G	0,5	CD4	34,37	HLA-G	CD4	3135	920	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|proliferation proliferation|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	HLA-G suppresses proliferation of CD4 -LRB- + -RRB- T-lymphocytes .
11572934	0	HLA-G	8,13	CD4	107,110	HLA-G	CD4	3135	920	Gene	Gene	protein|amod|START_ENTITY suppresses|nsubj|protein suppresses|dobj|response response|dep|cell cell|compound|END_ENTITY	Soluble HLA-G protein secreted by allo-specific CD4 + T cells suppresses the allo-proliferative response : a CD4 + T cell regulatory mechanism .
11572934	0	HLA-G	8,13	CD4	48,51	HLA-G	CD4	3135	920	Gene	Gene	protein|amod|START_ENTITY protein|acl|secreted secreted|nmod|cells cells|compound|END_ENTITY	Soluble HLA-G protein secreted by allo-specific CD4 + T cells suppresses the allo-proliferative response : a CD4 + T cell regulatory mechanism .
14991594	0	HLA-G	62,67	CD4	13,16	HLA-G	CD4	3135	920	Gene	Gene	molecule|amod|START_ENTITY express|dobj|molecule express|nsubj|+ +|compound|END_ENTITY	Alloreactive CD4 + and CD8 + T cells express the immunotolerant HLA-G molecule in mixed lymphocyte reactions : in vivo implications in transplanted patients .
15652415	0	HLA-G	17,22	CD4	64,67	HLA-G	CD4	3135	920	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|inhibitor inhibitor|nmod|activation activation|compound|END_ENTITY	Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo : rationale for the therapy of multiple_sclerosis .
23220581	0	HLA-G	8,13	CD4	72,75	HLA-G	CD4	3135	920	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Soluble HLA-G modulates miRNA-210 and miRNA-451 expression in activated CD4 + T lymphocytes .
24744146	0	HLA-G	11,16	CD4	6,9	HLA-G	CD4	3135	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD4 + HLA-G + regulatory T cells are potent suppressors of graft-versus-host_disease in vivo .
26187665	0	HLA-G	36,41	HOTAIR	20,26	HLA-G	HOTAIR	3135	100124700	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric_cancer cells .
20445010	0	HLA-G	27,32	Human_leukocyte_antigen-G	0,25	HLA-G	Human leukocyte antigen-G	3135	3135	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human_leukocyte_antigen-G -LRB- HLA-G -RRB- expression in cervical_lesions : association with cancer_progression , _ HPV_16 / 18_infection , and host immune response .
8666791	0	HLA-G	14,19	IFN-gamma	79,88	HLA-G	IFN-gamma	3135	3458	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of HLA-G in human mononuclear phagocytes and selective induction by IFN-gamma .
10330285	0	HLA-G	26,31	IL-10	0,5	HLA-G	IL-10	3135	3586	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes .
14592815	0	HLA-G	58,63	ILT2	99,103	HLA-G	ILT2	3135	10859	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	Primary cutaneous CD8 + and CD56 + T-cell_lymphomas express HLA-G and killer-cell inhibitory ligand , ILT2 .
19700612	0	HLA-G	66,71	KIR2DL4	34,41	HLA-G	KIR2DL4	3135	3805	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|interaction interaction|nmod|END_ENTITY	Possible gene-gene interaction of KIR2DL4 with its cognate ligand HLA-G in modulating risk for preeclampsia .
22934097	0	HLA-G	45,50	KIR2DL4	0,7	HLA-G	KIR2DL4	3135	3805	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|dep|receptor	KIR2DL4 -LRB- CD158d -RRB- : An activation receptor for HLA-G .
25855135	0	HLA-G	40,45	KIR2DL4	65,72	HLA-G	KIR2DL4	3135	3805	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Genetic polymorphisms and expression of HLA-G and its receptors , KIR2DL4 and LILRB1 , in non-small_cell_lung_cancer .
17549736	0	HLA-G	25,30	LILRB1	98,104	HLA-G	LILRB1	3135	10859	Gene	Gene	complex|nmod|START_ENTITY modulates|nsubj|complex modulates|dobj|antigen-presenting_cells antigen-presenting_cells|nmod|END_ENTITY	A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting_cells via LILRB1 .
25853899	0	HLA-G	64,69	LILRB1	73,79	HLA-G	LILRB1	3135	10859	Gene	Gene	START_ENTITY|nmod|Receptor Receptor|compound|END_ENTITY	The Paradox of High Availability and Low Recognition of Soluble HLA-G by LILRB1 Receptor in Rheumatoid_Arthritis Patients .
25649687	0	HLA-G	16,21	Leptin	0,6	HLA-G	Leptin	3135	3952	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways .
20126612	0	HLA-G	38,43	NK_receptor	11,22	HLA-G	NK receptor	3135	3804	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	Inhibitory NK_receptor recognition of HLA-G : regulation by contact residues and by cell specific expression at the fetal-maternal interface .
19890057	0	HLA-G	41,46	RREB-1	0,6	HLA-G	RREB-1	3135	6239	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	RREB-1 is a transcriptional repressor of HLA-G .
24054889	0	HLA-G	0,5	STAT3	86,91	HLA-G	STAT3	3135	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	HLA-G regulates the invasive properties of JEG-3 choriocarcinoma cells by controlling STAT3 activation .
26627200	0	HLA-G	14,19	TGF-b	0,5	HLA-G	TGF-b	3135	7040	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b induces HLA-G expression through inhibiting miR-152 in gastric_cancer cells .
19692629	0	HLA-G	42,47	human_leukocyte_antigen-G	15,40	HLA-G	human leukocyte antigen-G	3135	3135	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Correlation of human_leukocyte_antigen-G -LRB- HLA-G -RRB- expression and disease progression in epithelial ovarian_cancer .
21816853	0	HLA-G	38,43	intermedin	17,27	HLA-G	intermedin	3135	79924	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Adrenomedullin_2 / intermedin regulates HLA-G in human trophoblasts .
11857488	0	HLA-G_antigen	68,81	ILT2	104,108	HLA-G antigen	ILT2	3135	10859	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Specific activation of the non-classical class I histocompatibility HLA-G_antigen and expression of the ILT2 inhibitory receptor in human breast_cancer .
7959705	0	HLA-linked_heat-shock_protein_70-2	87,121	HSP70-2	123,130	HLA-linked heat-shock protein 70-2	HSP70-2	3306	3306	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A pentanucleotide tandem duplication polymorphism in the 3 ' untranslated region of the HLA-linked_heat-shock_protein_70-2 -LRB- HSP70-2 -RRB- gene .
7682582	0	HLA/A24	98,105	DBA/2	92,97	HLA/A24	DBA/2	53599(Tax:10090)	114086	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Abrogation of H-2-restricted CTL responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice .
19295543	0	HLA_DQB1	23,31	CD4	37,40	HLA DQB1	CD4	3119	920	Gene	Gene	START_ENTITY|nmod|T-cell T-cell|compound|END_ENTITY	Genetic association of HLA_DQB1 with CD4 + CD25 + -LRB- high -RRB- T-cell apoptosis in type 1 diabetes .
19722042	0	HLA_DRB1	57,65	HLA_DRB1	72,80	HLA DRB1	HLA DRB1	3123	3123	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Acute disseminated encephalomyelitis : clinical features , HLA_DRB1 * 1501 , HLA_DRB1 * 1503 , HLA_DQA1 * 0102 , HLA_DQB1 * 0602 , and HLA_DPA1 * 0301 allelic association study .
19722042	0	HLA_DRB1	72,80	HLA_DRB1	57,65	HLA DRB1	HLA DRB1	3123	3123	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Acute disseminated encephalomyelitis : clinical features , HLA_DRB1 * 1501 , HLA_DRB1 * 1503 , HLA_DQA1 * 0102 , HLA_DQB1 * 0602 , and HLA_DPA1 * 0301 allelic association study .
9066649	0	HLA_class_I_antigen	61,80	IFN-gamma	11,20	HLA class I antigen	IFN-gamma	100507436	3458	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of IFN-gamma , TNF-alpha and EGF on the expression of HLA_class_I_antigen and the proliferation of human hepatocellular_carcinoma HepG2 cells .
2122936	0	HLA_class_I_antigen	8,27	interferon-gamma	109,125	HLA class I antigen	interferon-gamma	100507436	3458	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Soluble HLA_class_I_antigen secretion by normal lymphocytes : relationship with cell activation and effect of interferon-gamma .
10447404	0	HLA_class_I_molecule	27,47	CD8	8,11	HLA class I molecule	CD8	3135	925	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Soluble CD8 stabilizes the HLA_class_I_molecule by promoting beta2M exchange : analysis in real-time .
26830115	0	HLA_complex_group_22	18,38	HCG22	45,50	HLA complex group 22	HCG22	285834	285834	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants near the HLA_complex_group_22 gene -LRB- HCG22 -RRB- confer increased susceptibility to late-onset asthma in Japanese populations .
1386162	0	HLF	34,37	E2A	45,48	HLF	E2A	3131	6929	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Fusion of the leucine zipper gene HLF to the E2A gene in human acute_B-lineage_leukemia .
7556072	0	HLF	33,36	hepatic_leukemia_factor	8,31	HLF	hepatic leukemia factor	690286(Tax:10116)	690286(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The rat hepatic_leukemia_factor -LRB- HLF -RRB- gene encodes two transcriptional activators with distinct circadian rhythms , tissue distributions and target preferences .
23533643	0	HLH-29	75,81	ferritin	85,93	HLH-29	ferritin	185136(Tax:6239)	171934(Tax:6239)	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response .
27065329	0	HLJ1	0,4	Src	22,25	HLJ1	Src	11080	6714	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms .
15782117	0	HLJ1	73,77	YY1	27,30	HLJ1	YY1	11080	7528	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer_cell_invasion .
21345358	0	HLJ1	39,43	YY1	84,87	HLJ1	YY1	11080	7528	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Hepatitis_B_virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells .
20096653	0	HLTF	44,48	Rad5	14,18	Rad6	Rad5	852822(Tax:4932)	850719(Tax:4932)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of yeast Rad5 and its human orthologs , HLTF and SHPRH in DNA damage tolerance .
22989111	0	HLX1	35,39	Hepatocyte_growth_factor	0,24	HLX1	Hepatocyte growth factor	3142	3082	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor regulates HLX1 gene expression to modulate HTR-8 / SVneo trophoblast cells .
8095486	0	HLX1	58,62	TGFB2	24,29	HLX1	TGFB2	3142	7042	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q .
15772702	0	HLXB9	0,5	IL6	16,19	HLXB9	IL6	3110	3569	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	HLXB9 activates IL6 in Hodgkin_lymphoma cell lines and is regulated by PI3K signalling involving E2F3 .
15540222	0	HLXB9	14,19	MYB	42,45	HLXB9	MYB	3110	4602	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of HLXB9 by juxtaposition with MYB via formation of t -LRB- 6 ; 7 -RRB- -LRB- q23 ; q36 -RRB- in an AML-M4 cell line -LRB- GDM-1 -RRB- .
26456220	0	HMBOX1	0,6	MT2A	22,26	HMBOX1	MT2A	79618	4502	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells .
10790212	0	HMBS	56,60	hydroxymethylbilane_synthase	26,54	HMBS	hydroxymethylbilane synthase	3145	3145	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular analysis of the hydroxymethylbilane_synthase -LRB- HMBS -RRB- gene in Italian patients with acute intermittent porphyria : report of four novel mutations .
8164686	0	HMG-1	24,29	progesterone_receptor	39,60	HMG-1	progesterone receptor	10354	5241	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	The DNA-bending protein HMG-1 enhances progesterone_receptor binding to its target DNA sequences .
15752612	0	HMG-CoA_lyase	41,54	HL	56,58	HMG-CoA lyase	HL	3155	3155	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Skipping of exon 2 and exons 2 plus 3 of HMG-CoA_lyase -LRB- HL -RRB- gene produces the loss of beta sheets 1 and 2 in the recently proposed -LRB- beta-alpha -RRB- 8 TIM barrel model of HL .
8006019	0	HMG1	32,36	TATA-binding_protein	112,132	HMG1	TATA-binding protein	10354	6908	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding_protein .
9931456	0	HMG1	61,65	high-mobility-group_1	38,59	HMG1	high-mobility-group 1	395724(Tax:9031)	395724(Tax:9031)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Selection of a cDNA clone for chicken high-mobility-group_1 -LRB- HMG1 -RRB- protein through its unusually conserved 3 ' - untranslated region , and improved expression of recombinant HMG1 in Escherichia_coli .
12565837	0	HMG1	39,43	high_mobility_group_protein-1	8,37	HMG1	high mobility group protein-1	10354	10354	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_protein-1 -LRB- HMG1 -RRB- in amyloid-beta homeostasis .
16533045	0	HMG1-boxes_1_and_2	71,89	ERK	0,3	HMG1-boxes 1 and 2	ERK	10354	5594	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes_1_and_2 of the RNA polymerase I transcription factor UBF .
17723105	0	HMGA1	0,5	BRG1	55,59	HMGA1	BRG1	3159	6597	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	HMGA1 mediates the activation of the CRYAB promoter by BRG1 .
23945276	0	HMGA1	0,5	EMT	75,78	HMGA1	EMT	3159	3702	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	HMGA1 promotes metastatic processes in basal-like breast_cancer regulating EMT and stemness .
15713121	0	HMGA1	24,29	High-mobility-group_A1	0,22	HMGA1	High-mobility-group A1	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	High-mobility-group_A1 -LRB- HMGA1 -RRB- proteins down-regulate the expression of the recombination_activating_gene_2 -LRB- RAG2 -RRB- .
16341121	0	HMGA1	24,29	High_Mobility_Group_A1	0,22	HMGA1	High Mobility Group A1	3159	3159	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	High_Mobility_Group_A1 -LRB- HMGA1 -RRB- proteins interact with p53 and inhibit its apoptotic activity .
15378028	0	HMGA1	53,58	KIT_ligand	6,16	HMGA1	KIT ligand	3159	4254	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|promoter promoter|compound|END_ENTITY	Human KIT_ligand promoter is positively regulated by HMGA1 in breast_and_ovarian_cancer cells .
19389484	0	HMGA1	118,123	PSF	175,178	HMGA1	PSF	15361(Tax:10090)	71514(Tax:10090)	Gene	Gene	START_ENTITY|appos|factor factor|appos|END_ENTITY	Transcriptional activity of the murine retinol-binding_protein gene is regulated by a multiprotein complex containing HMGA1 , p54 nrb/NonO , protein-associated splicing factor -LRB- PSF -RRB- and steroidogenic_factor_1 -LRB- SF1 -RRB- / liver_receptor_homologue_1 -LRB- LRH-1 -RRB- .
25572132	0	HMGA1	15,20	TGF-b1	0,6	HMGA1	TGF-b1	3159	7040	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b1 induces HMGA1 expression in human breast_cancer cells : Implications of the involvement of HMGA1 in TGF-b signaling .
24696416	0	HMGA1	0,5	b-catenin	21,30	HMGA1	b-catenin	3159	1499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HMGA1 interacts with b-catenin to positively regulate Wnt/b-catenin signaling in colorectal_cancer cells .
15313913	0	HMGA1	82,87	high_mobility_group_A1	58,80	HMGA1	high mobility group A1	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Identification of the genes up - and down-regulated by the high_mobility_group_A1 -LRB- HMGA1 -RRB- proteins : tissue specificity of the HMGA1-dependent gene regulation .
16187170	0	HMGA1	41,46	high_mobility_group_A1	17,39	HMGA1	high mobility group A1	3159	3159	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Determination of high_mobility_group_A1 -LRB- HMGA1 -RRB- expression in hepatocellular_carcinoma : a potential prognostic marker .
18651940	0	HMGA1	112,117	high_mobility_group_A1	88,110	HMGA1	high mobility group A1	3159	3159	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic characterisation , chromosomal assignment and in vivo localisation of the canine high_mobility_group_A1 -LRB- HMGA1 -RRB- gene .
23036517	0	HMGA1	56,61	high_mobility_group_A1	32,54	HMGA1	high mobility group A1	3159	3159	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Functional relationship between high_mobility_group_A1 -LRB- HMGA1 -RRB- protein and insulin-like_growth_factor-binding_protein_3 -LRB- IGFBP-3 -RRB- in human chondrocytes .
17434141	0	HMGA1	67,72	insulin_receptor	21,37	HMGA1	insulin receptor	3159	3643	Gene	Gene	impairing|dobj|START_ENTITY END_ENTITY|advcl|impairing	Fatty_acid represses insulin_receptor gene expression by impairing HMGA1 through protein kinase Cepsilon .
17510394	0	HMGA1	0,5	insulin_receptor	32,48	HMGA1	insulin receptor	3159	3643	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|transcription transcription|nmod|END_ENTITY	HMGA1 controls transcription of insulin_receptor to regulate cyclin_D1 translation in pancreatic_cancer cells .
22355763	0	HMGA1	0,5	insulin_receptor	50,66	HMGA1	insulin receptor	3159	3643	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	HMGA1 is a novel downstream nuclear target of the insulin_receptor signaling pathway .
25100012	0	HMGA1	0,5	miR-195	25,32	HMGA1	miR-195	15361(Tax:10090)	387190(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	HMGA1 is a new target of miR-195 involving isoprenaline-induced cardiomyocyte hypertrophy .
23796420	0	HMGA1	75,80	miR-26a	0,7	HMGA1	miR-26a	3159	407015	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-26a inhibits proliferation and motility in bladder_cancer by targeting HMGA1 .
21138859	0	HMGA1	14,19	microRNA-296	34,46	HMGA1	microRNA-296	3159	407022	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Regulation of HMGA1 expression by microRNA-296 affects prostate_cancer growth and invasion .
17960875	0	HMGA1a	64,70	Homeodomain-interacting_protein_kinase-2	0,40	HMGA1a	Homeodomain-interacting protein kinase-2	3159	28996	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Homeodomain-interacting_protein_kinase-2 -LRB- HIPK2 -RRB- phosphorylates HMGA1a at Ser-35 , Thr-52 , and Thr-77 and modulates its DNA binding affinity .
26319392	0	HMGA2	10,15	Akt	51,54	HMGA2	Akt	8091	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Amplified HMGA2 promotes cell growth by regulating Akt pathway in AML .
22019704	0	HMGA2	29,34	BMP4	0,4	HMGA2	BMP4	8091	652	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	BMP4 increases expression of HMGA2 in mesenchymal stem cells .
26250458	0	HMGA2	21,26	EMT	44,47	HMGA2	EMT	8091	3702	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	The critical role of HMGA2 in regulation of EMT in epithelial ovarian_carcinomas .
26250458	0	HMGA2	21,26	EMT	44,47	HMGA2	EMT	8091	3702	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	The critical role of HMGA2 in regulation of EMT in epithelial ovarian_carcinomas .
26964871	0	HMGA2	46,51	FN1	30,33	HMGA2	FN1	8091	2335	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal_cancer .
21273026	0	HMGA2	108,113	HMGA2	18,23	HMGA2	HMGA2	8091	8091	Gene	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of HMGA2 in bladder_cancer and its association with clinicopathologic features and prognosis HMGA2 as a prognostic marker of bladder_cancer .
21273026	0	HMGA2	18,23	HMGA2	108,113	HMGA2	HMGA2	8091	8091	Gene	Gene	Overexpression|nmod|START_ENTITY END_ENTITY|nsubj|Overexpression	Overexpression of HMGA2 in bladder_cancer and its association with clinicopathologic features and prognosis HMGA2 as a prognostic marker of bladder_cancer .
12021922	0	HMGA2	30,35	HMGI-C	21,27	HMGA2	HMGI-C	8091	8091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Translocation of the HMGI-C -LRB- HMGA2 -RRB- gene in a benign mesenchymoma -LRB- chondrolipoangioma -RRB- .
25368430	0	HMGA2	36,41	LIN28B	19,25	HMGA2	LIN28B	8091	389421	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	MUC1-C Induces the LIN28B > LET-7 > HMGA2 Axis to Regulate Self-Renewal in NSCLC .
26406941	0	HMGA2	18,23	MiR-204	0,7	HMGA2	MiR-204	8091	406987	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-204 regulates HMGA2 expression and inhibits cell proliferation in human thyroid_cancer .
25218351	0	HMGA2	0,5	Slug	35,39	HMGA2	Slug	8091	6591	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon_cancer progression .
25300915	0	HMGA2	35,40	caspase_2	76,85	HMGA2	caspase 2	8091	835	Gene	Gene	role|nmod|START_ENTITY role|nmod|apoptosis apoptosis|nmod|END_ENTITY	A novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase_2 in primary human fibroblast cells .
23625920	0	HMGA2	76,81	high_mobility_group_AT-hook_2	40,69	TTF-1	high mobility group AT-hook 2	7270	8091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	MicroRNA-33a mediates the regulation of high_mobility_group_AT-hook_2 gene -LRB- HMGA2 -RRB- by thyroid_transcription_factor_1 -LRB- TTF-1 / NKX2-1 -RRB- .
23591597	0	HMGA2	34,39	miR-154	0,7	HMGA2	miR-154	8091	406946	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-154 inhibits EMT by targeting HMGA2 in prostate_cancer cells .
24531895	0	HMGB	75,79	high_mobility_group_box	50,73	HMGB	high mobility group box	6749	6749	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	A systematic nomenclature for the redox states of high_mobility_group_box -LRB- HMGB -RRB- proteins .
25043672	0	HMGB-1	35,41	High_mobility_group_box_1	0,25	HMGB-1	High mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High_mobility_group_box_1 protein -LRB- HMGB-1 -RRB- : a pathogenic role in preeclampsia ?
21520052	0	HMGB-1	0,6	IL-6	15,19	HMGB-1	IL-6	3146	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src , Akt and NF-kB pathways .
21041074	0	HMGB-1	20,26	RAGE	52,56	HMGB-1	RAGE	3146	177	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nsubj|levels	Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients .
22710699	0	HMGB-1	47,53	high-mobility_group_box_1	12,37	HMGB-1	high-mobility group box 1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Recombinant high-mobility_group_box_1 protein -LRB- HMGB-1 -RRB- promotes myeloid_differentiation_primary_response_protein_88 -LRB- Myd88 -RRB- upregulation in mouse primary cortical neurons .
26779828	0	HMGB-1	64,70	high-mobility_group_box_1	29,54	HMGB-1	high-mobility group box 1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The pro-inflammatory role of high-mobility_group_box_1 protein -LRB- HMGB-1 -RRB- in photoreceptors and retinal explants exposed to elevated pressure .
22189477	0	HMGB-1	83,89	high-mobility_group_box_chromosomal_protein-1	36,81	HMGB-1	high-mobility group box chromosomal protein-1	3146	3146	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression and localization of high-mobility_group_box_chromosomal_protein-1 -LRB- HMGB-1 -RRB- in human osteoarthritic cartilage .
25810808	0	HMGB-1	91,97	high_mobility_group_box-1	64,89	HMGB-1	high mobility group box-1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CO2 pneumoperitoneum preserves b-arrestin 2 content and reduces high_mobility_group_box-1 -LRB- HMGB-1 -RRB- expression in an animal model of peritonitis .
26261566	0	HMGB-1	39,45	high_mobility_group_box_1	12,37	HMGB-1	high mobility group box 1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of high_mobility_group_box_1 -LRB- HMGB-1 -RRB- in the diabetic_retinopathy_inflammation and apoptosis .
26350087	0	HMGB1	11,16	CD133	70,75	HMGB1	CD133	3146	8842	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|compound|END_ENTITY	Effects of HMGB1 on proliferation and apoptosis of human brain_glioma CD133 cells .
15331624	0	HMGB1	54,59	CD14	75,79	HMGB1	CD14	15289(Tax:10090)	12475(Tax:10090)	Gene	Gene	release|dobj|START_ENTITY release|nmod|END_ENTITY	Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14 - and TNF-dependent mechanisms .
22809173	0	HMGB1	0,5	CD14	79,83	HMGB1	CD14	3146	929	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|differentiation differentiation|nmod|monocytes monocytes|nummod|+ +|compound|END_ENTITY	HMGB1 promotes the differentiation of Th17 via up-regulating TLR2 and IL-23 of CD14 + monocytes from patients with rheumatoid_arthritis .
23508573	0	HMGB1	40,45	CD14	100,104	HMGB1	CD14	3146	929	Gene	Gene	high_mobility_group_box_1|appos|START_ENTITY Signaling|nmod|high_mobility_group_box_1 Signaling|nsubj|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
25660311	0	HMGB1	0,5	CD14	128,132	HMGB1	CD14	15289(Tax:10090)	12475(Tax:10090)	Gene	Gene	Binds|nsubj|START_ENTITY Binds|nmod|END_ENTITY	HMGB1 Binds to Lipoteichoic_Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic_Acid to CD14 and TLR2 .
25924590	0	HMGB1	0,5	CTGF	45,49	HMGB1	CTGF	3146	1490	Gene	Gene	Enhances|nsubj|START_ENTITY Enhances|dobj|Expression Expression|nmod|END_ENTITY	HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-b via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells .
25222915	0	HMGB1	49,54	High-Mobility_Group_Box_1	14,39	HMGB1	High-Mobility Group Box 1	3146	3146	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	Extracellular High-Mobility_Group_Box_1 Protein -LRB- HMGB1 -RRB- as a Mediator of Persistent Pain .
20844833	0	HMGB1	35,40	High-mobility_group_box-1	0,25	HMGB1	High-mobility group box-1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High-mobility_group_box-1 protein -LRB- HMGB1 -RRB- is increased in antineutrophilic cytoplasmatic antibody -LRB- ANCA -RRB- - associated vasculitis with renal manifestations .
15803152	0	HMGB1	35,40	High-mobility_group_box_1	0,25	HMGB1	High-mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High-mobility_group_box_1 protein -LRB- HMGB1 -RRB- : nuclear weapon in the immune arsenal .
16513409	0	HMGB1	27,32	High-mobility_group_box_1	0,25	HMGB1	High-mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High-mobility_group_box_1 -LRB- HMGB1 -RRB- protein : friend and foe .
24412753	0	HMGB1	27,32	High-mobility_group_box_1	0,25	HMGB1	High-mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High-mobility_group_box_1 -LRB- HMGB1 -RRB- protein regulates tumor-associated cell migration through the interaction with BTB domain .
26954343	0	HMGB1	27,32	High_Mobility_Group-Box_1	0,25	HMGB1	High Mobility Group-Box 1	3146	3146	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	High_Mobility_Group-Box_1 -LRB- HMGB1 -RRB- levels are increased in amniotic_fluid of women with intra-amniotic_inflammation-determined preterm_birth , and the source may be the damaged fetal membranes .
16644144	0	HMGB1	72,77	High_Mobility_Group_B1	48,70	HMGB1	High Mobility Group B1	3146	3146	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Cloning the genes and DNA binding properties of High_Mobility_Group_B1 -LRB- HMGB1 -RRB- proteins from the human blood_flukes Schistosoma_mansoni and Schistosoma_japonicum .
26118980	0	HMGB1	50,55	High_Mobility_Group_Box-1_Protein	15,48	HMGB1	High Mobility Group Box-1 Protein	3146	3146	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of High_Mobility_Group_Box-1_Protein -LRB- HMGB1 -RRB- with Clinicopathological Parameters in Primary Retinoblastoma .
25275029	0	HMGB1	54,59	High_Mobility_Group_Box_1	27,52	HMGB1	High Mobility Group Box 1	3146	3146	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Prognostic Significance of High_Mobility_Group_Box_1 -LRB- HMGB1 -RRB- Expression in Patients with Colorectal_Cancer .
25549101	0	HMGB1	35,40	High_Mobility_Group_Box_1	8,33	HMGB1	High Mobility Group Box 1	3146	3146	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of High_Mobility_Group_Box_1 -LRB- HMGB1 -RRB- in SCA17 Pathogenesis .
15653118	0	HMGB1	27,32	High_mobility_group_box_1	0,25	HMGB1	High mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High_mobility_group_box_1 -LRB- HMGB1 -RRB- protein : possible amplification signal in the pathogenesis of falciparum_malaria .
21241404	0	HMGB1	27,32	High_mobility_group_box_1	0,25	HMGB1	High mobility group box 1	3146	3146	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	High_mobility_group_box_1 -LRB- HMGB1 -RRB- levels in the placenta and in serum in preeclampsia .
21441719	0	HMGB1	27,32	High_mobility_group_box_1	0,25	HMGB1	High mobility group box 1	403170(Tax:9615)	403170(Tax:9615)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High_mobility_group_box_1 -LRB- HMGB1 -RRB- protein is present in the cerebrospinal fluid of dogs with encephalitis .
26105447	1	HMGB1	42,47	High_mobility_group_box_1	7,32	HMGB1	High mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High_mobility_group_box_1 protein -LRB- HMGB1 -RRB- : A pathogenic role in preeclampsia ?
25899805	0	HMGB1	46,51	Lysozyme	29,37	HMGB1	Lysozyme	3146	4069	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Anti-Inflammatory Effects of Lysozyme Against HMGB1 in Human Endothelial Cells and in Mice .
24418846	0	HMGB1	54,59	MIR34A	0,6	HMGB1	MIR34A	3146	407040	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell .
21248133	0	HMGB1	0,5	Mac1	24,28	HMGB1	Mac1	3146	3684	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration .
26571038	0	HMGB1	106,111	P38_MAPK	148,156	HMGB1	P38 MAPK	3146	1432	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Pathway Pathway|compound|END_ENTITY	The Protective Role of Interleukin-33 in Myocardial_Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38_MAPK Signaling Pathway .
26721185	0	HMGB1	15,20	PPARy	0,5	HMGB1	PPARy	3146	5468	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	PPARy inhibits HMGB1 expression through upregulation of miR-142-3p in vitro and in vivo .
15644117	0	HMGB1	63,68	RAGE	0,4	HMGB1	RAGE	15289(Tax:10090)	26448(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY receptor|nmod|activity receptor|nsubj|END_ENTITY	RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages .
16407300	0	HMGB1	16,21	RAGE	69,73	HMGB1	RAGE	15289(Tax:10090)	11596(Tax:10090)	Gene	Gene	amphoterin|appos|START_ENTITY pair|compound|amphoterin pair|appos|END_ENTITY	The amphoterin -LRB- HMGB1 -RRB- / receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- pair modulates myoblast proliferation , apoptosis , adhesiveness , migration , and invasiveness .
18264787	0	HMGB1	161,166	RAGE	108,112	HMGB1	RAGE	3146	177	Gene	Gene	B1|appos|START_ENTITY pathways|nmod|B1 signaling|dobj|pathways Convergence|acl|signaling Convergence|nmod|receptor receptor|appos|END_ENTITY	Convergence and amplification of toll-like receptor -LRB- TLR -RRB- and receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- signaling pathways via high mobility group B1 -LRB- HMGB1 -RRB- .
18302500	0	HMGB1	0,5	RAGE	74,78	HMGB1	RAGE	3146	177	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|dependent dependent|nmod|END_ENTITY	HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE .
18331230	0	HMGB1	22,27	RAGE	0,4	HMGB1	RAGE	3146	101669765	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	RAGE as a receptor of HMGB1 -LRB- Amphoterin -RRB- : roles in health and disease .
19005067	0	HMGB1	4,9	RAGE	19,23	HMGB1	RAGE	15289(Tax:10090)	11596(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY mediates|nsubj|receptor mediates|advmod|END_ENTITY	The HMGB1 receptor RAGE mediates ischemic_brain_damage .
19876719	0	HMGB1	18,23	RAGE	49,53	HMGB1	RAGE	3146	101669765	Gene	Gene	protein|nummod|START_ENTITY expression|nmod|protein END_ENTITY|nsubj|expression	The expression of HMGB1 protein and its receptor RAGE in human malignant_tumors .
20100543	0	HMGB1	84,89	RAGE	108,112	HMGB1	RAGE	25459(Tax:10116)	362787(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptors receptors|appos|END_ENTITY	Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1 , HMGB1 receptors -LRB- RAGE and TLR4 -RRB- , NF-kappaB expression .
20100543	0	HMGB1	91,96	RAGE	108,112	HMGB1	RAGE	25459(Tax:10116)	362787(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY receptors|appos|END_ENTITY	Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1 , HMGB1 receptors -LRB- RAGE and TLR4 -RRB- , NF-kappaB expression .
20163887	0	HMGB1	0,5	RAGE	47,51	HMGB1	RAGE	3146	177	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|factor-kB factor-kB|acl|signaling signaling|nmod|END_ENTITY	HMGB1 activates nuclear factor-kB signaling by RAGE and increases the production of TNF-a in human umbilical vein endothelial cells .
21187488	0	HMGB1	24,29	RAGE	81,85	HMGB1	RAGE	3146	101669765	Gene	Gene	High-mobility_group_B1|appos|START_ENTITY High-mobility_group_B1|appos|END_ENTITY	High-mobility_group_B1 -LRB- HMGB1 -RRB- and receptor for advanced glycation end-products -LRB- RAGE -RRB- expression in canine lymphoma .
21494799	0	HMGB1	0,5	RAGE	67,71	HMGB1	RAGE	3146	177	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|permeability permeability|nmod|monolayer monolayer|nmod|pathways pathways|compound|END_ENTITY	HMGB1 increases permeability of the endothelial cell monolayer via RAGE and Src family tyrosine kinase pathways .
21990362	0	HMGB1	64,69	RAGE	134,138	HMGB1	RAGE	3146	177	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|receptor receptor|nmod|products products|appos|END_ENTITY	Heparan sulfate is essential for high mobility group protein 1 -LRB- HMGB1 -RRB- signaling by the receptor for advanced glycation end products -LRB- RAGE -RRB- .
22549347	0	HMGB1	46,51	RAGE	24,28	HMGB1	RAGE	3146	177	Gene	Gene	ligands|dobj|START_ENTITY ligands|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship of soluble RAGE and RAGE ligands HMGB1 and EN-RAGE to endothelial dysfunction in type 1 and type 2 diabetes_mellitus .
24073286	0	HMGB1	8,13	RAGE	70,74	HMGB1	RAGE	3146	101669765	Gene	Gene	adipokine|nsubj|START_ENTITY adipokine|acl|stimulating stimulating|nmod|receptor receptor|amod|END_ENTITY	Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line : contribution to chronic inflammation in fat tissue .
24474694	0	HMGB1	39,44	RAGE	98,102	HMGB1	RAGE	3146	177	Gene	Gene	protein|compound|START_ENTITY A-box|nmod|protein peptide|nmod|A-box reverses|nsubj|peptide reverses|nmod|receptor receptor|amod|END_ENTITY	An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor .
25652880	0	HMGB1	19,24	RAGE	75,79	HMGB1	RAGE	3146	5891	Gene	Gene	release|compound|START_ENTITY promotes|nsubj|release promotes|dobj|survival survival|nmod|activation activation|amod|END_ENTITY	Autophagy-mediated HMGB1 release promotes gastric_cancer cell survival via RAGE activation of extracellular_signal-regulated_kinases_1 / 2 .
25772690	0	HMGB1	27,32	RAGE	96,100	HMGB1	RAGE	3146	177	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	High motility group box 1 -LRB- HMGB1 -RRB- protein and its receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- expression in chronic rhinosinusitis without nasal_polyps .
25813710	0	HMGB1	0,5	RAGE	18,22	HMGB1	RAGE	25459(Tax:10116)	81722(Tax:10116)	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral_hemorrhage .
23148306	0	HMGB1	21,26	TLR4	0,4	HMGB1	TLR4	3146	7099	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	TLR4 as receptor for HMGB1 induced muscle_dysfunction in myositis .
21336543	0	HMGB1	152,157	TNF-a	112,117	HMGB1	TNF-a	3146	7124	Gene	Gene	production|nummod|START_ENTITY cells|appos|production production|nmod|cells production|appos|END_ENTITY	Different inhibitory effects of kynurenic_acid and a novel kynurenic_acid analogue on tumour_necrosis_factor-a -LRB- TNF-a -RRB- production by mononuclear cells , HMGB1 production by monocytes and HNP1-3 secretion by neutrophils .
22154216	0	HMGB1	27,32	TNF-a	0,5	HMGB1	TNF-a	3146	7124	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	TNF-a induced secretion of HMGB1 from non-immune canine mammary epithelial cells -LRB- MTH53A -RRB- .
25660311	0	HMGB1	0,5	TNF-a	46,51	HMGB1	TNF-a	15289(Tax:10090)	21926(Tax:10090)	Gene	Gene	Binds|nsubj|START_ENTITY Binds|nmod|END_ENTITY	HMGB1 Binds to Lipoteichoic_Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic_Acid to CD14 and TLR2 .
25681553	0	HMGB1	16,21	Toll-like_receptor_9	114,134	HMGB1	Toll-like receptor 9	15289(Tax:10090)	81897(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular_carcinoma through Toll-like_receptor_9 .
23158987	0	HMGB1	11,16	VEGF-C	24,30	HMGB1	VEGF-C	3146	7424	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of HMGB1 on the VEGF-C expression and proliferation of esophageal squamous cancer cells -RSB- .
26578599	0	HMGB1	0,5	XPA	21,24	HMGB1	XPA	3146	7507	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells .
17940748	0	HMGB1	36,41	antithrombin_III	10,26	HMGB1	antithrombin III	25459(Tax:10116)	304917(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	High dose antithrombin_III inhibits HMGB1 and improves endotoxin-induced acute_lung_injury in rats .
26469759	0	HMGB1	0,5	clusterin	19,28	HMGB1	clusterin	3146	1191	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	HMGB1 induction of clusterin creates a chemoresistant niche in human prostate_tumor cells .
17975839	0	HMGB1	69,74	high-mobility_group_box-1	42,67	HMGB1	high-mobility group box-1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Induction and subcellular localization of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in the postischemic rat brain .
22909167	0	HMGB1	39,44	high-mobility_group_box-1	12,37	HMGB1	high-mobility group box-1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in the pathogenesis of asthma .
23400574	0	HMGB1	46,51	high-mobility_group_box-1	19,44	HMGB1	high-mobility group box-1	3146	3146	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in patients with severe or uncomplicated Plasmodium_falciparum malaria .
26765765	0	HMGB1	41,46	high-mobility_group_box-1	14,39	HMGB1	high-mobility group box-1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in the basilar artery after experimental subarachnoid_hemorrhage .
17334246	0	HMGB1	39,44	high-mobility_group_box_1	12,37	HMGB1	High-mobility group box 1	3146	3146	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Circulating high-mobility_group_box_1 -LRB- HMGB1 -RRB- concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis .
23658798	0	HMGB1	120,125	high-mobility_group_box_1	93,118	HMGB1	high-mobility group box 1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Identification and characterization of the direct interaction between methotrexate -LRB- MTX -RRB- and high-mobility_group_box_1 -LRB- HMGB1 -RRB- protein .
24306421	0	HMGB1	44,49	high-mobility_group_box_1	17,42	HMGB1	high-mobility group box 1	3146	3146	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Emerging role of high-mobility_group_box_1 -LRB- HMGB1 -RRB- in liver_diseases .
24383926	0	HMGB1	36,41	high-mobility_group_box_1	9,34	HMGB1	high-mobility group box 1	3146	3146	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Enhanced high-mobility_group_box_1 -LRB- HMGB1 -RRB- modulates regulatory T cells -LRB- Treg -RRB- / T helper 17 -LRB- Th17 -RRB- balance via toll-like receptor -LRB- TLR -RRB- -4 - interleukin -LRB- IL -RRB- -6 pathway in patients with chronic_hepatitis_B .
24924349	0	HMGB1	44,49	high-mobility_group_box_1	17,42	HMGB1	high-mobility group box 1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Early release of high-mobility_group_box_1 -LRB- HMGB1 -RRB- from neurons in experimental subarachnoid_hemorrhage in vivo and in vitro .
26880688	0	HMGB1	51,56	high-mobility_group_box_1	24,49	HMGB1	high-mobility group box 1	3146	3146	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	Plasma concentration of high-mobility_group_box_1 -LRB- HMGB1 -RRB- after 100 drop to vertical jumps and after a 1200-km bicycle race .
19148477	0	HMGB1	74,79	high_mobility_group_box-1	47,72	HMGB1	high mobility group box-1	3146	3146	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Short hairpin RNA -LRB- shRNA -RRB- constructs targeting high_mobility_group_box-1 -LRB- HMGB1 -RRB- expression leads to inhibition of prostate_cancer cell survival and apoptosis .
15379539	0	HMGB1	51,56	high_mobility_group_box_1	24,49	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The long acidic tail of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes .
19616266	0	HMGB1	57,62	high_mobility_group_box_1	30,55	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Factors associated with serum high_mobility_group_box_1 -LRB- HMGB1 -RRB- levels in a general population .
21872885	0	HMGB1	35,40	high_mobility_group_box_1	8,33	HMGB1	high mobility group box 1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box_1 -LRB- HMGB1 -RRB- in wound healing .
22204001	0	HMGB1	53,58	high_mobility_group_box_1	26,51	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Poly -LRB- ADP-ribosyl -RRB- ation of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein enhances inhibition of efferocytosis .
22884669	0	HMGB1	52,57	high_mobility_group_box_1	25,50	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Elevated serum levels of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein in dengue-infected patients are associated with disease symptoms and secondary_infection .
23506269	0	HMGB1	47,52	high_mobility_group_box_1	20,45	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Systemic release of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein is associated with severe and fatal Plasmodium_falciparum_malaria .
24578610	0	HMGB1	138,143	high_mobility_group_box_1	112,137	HMGB1	high mobility group box 1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Ulinastatin preconditioning attenuates inflammatory reaction of hepatic_ischemia reperfusion injury in rats via high_mobility_group_box_1 -LRB- HMGB1 -RRB- inhibition .
24681824	0	HMGB1	39,44	high_mobility_group_box_1	12,37	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of high_mobility_group_box_1 -LRB- HMGB1 -RRB- in colorectal_cancer .
25669692	0	HMGB1	66,71	high_mobility_group_box_1	31,56	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Increased plasma levels of the high_mobility_group_box_1 protein -LRB- HMGB1 -RRB- are associated with a higher score of gastrointestinal_dysfunction in individuals with autism .
26367307	0	HMGB1	141,146	high_mobility_group_box_1	114,139	HMGB1	high mobility group box 1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Toll-like_receptor_4 signaling : A common pathway for interactions between prooxidants and extracellular disulfide high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein-coupled activation .
26869083	0	HMGB1	90,95	high_mobility_group_box_1	63,88	HMGB1	high mobility group box 1	3146	3146	Gene	Gene	interactions|appos|START_ENTITY interactions|amod|END_ENTITY	Optimization of surface plasmon resonance experiments : Case of high_mobility_group_box_1 -LRB- HMGB1 -RRB- interactions .
17196331	0	HMGB1	77,82	high_mobility_group_box_protein_1	42,75	HMGB1	high mobility group box protein 1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Distribution and cellular localization of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in the spinal cord of a transgenic mouse model of ALS .
23143556	0	HMGB1	60,65	high_mobility_group_box_protein_1	25,58	HMGB1	high mobility group box protein 1	3146	3146	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated serum levels of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in patients with ankylosing_spondylitis and its association with disease activity and quality of life .
25779452	0	HMGB1	43,48	high_mobility_group_box_protein_1	8,41	HMGB1	high mobility group box protein 1	3146	3146	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in peripheral blood from patients with multiple_sclerosis .
25879961	0	HMGB1	43,48	high_mobility_group_box_protein_1	8,41	HMGB1	high mobility group box protein 1	3146	3146	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in peripheral blood from patients with multiple_sclerosis .
25879961	0	HMGB1	43,48	high_mobility_group_box_protein_1	8,41	HMGB1	high mobility group box protein 1	3146	3146	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in peripheral blood from patients with multiple_sclerosis .
24710933	0	HMGB1	65,70	miR-200c	0,8	HMGB1	miR-200c	3146	406985	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-200c inhibits metastasis of breast_cancer cells by targeting HMGB1 .
23803172	0	HMGB1	31,36	p65	53,56	HMGB1	p65	3146	5970	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression and significance of HMGB1 , TLR4 and NF-kB p65 in human epidermal_tumors .
20036050	0	HMGB2	0,5	p53	17,20	HMGB2	p53	3148	7157	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	HMGB2 stabilizes p53 by interfering with E6/E6AP-mediated p53 degradation in human_papillomavirus-positive HeLa cells .
24732207	0	HMGCR	83,88	3-hydroxy-3-methylglutaryl-CoA_reductase	41,81	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	3156	3156	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Developmental processes regulated by the 3-hydroxy-3-methylglutaryl-CoA_reductase -LRB- HMGCR -RRB- pathway : highlights from animal studies .
24226717	0	HMGCR	41,46	SCP2	32,36	HMGCR	SCP2	3156	6342	Gene	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Increased bile lithogenicity by SCP2 via HMGCR and CYP7A1 regulation in human hepatocytes .
25605429	0	HMGCR	107,112	miR-21	0,6	HMGCR	miR-21	3156	406991	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic_fatty_liver_disease by targeting HMGCR .
8760375	0	HMGI	61,65	high-mobility-group_I	38,59	HMGI	high-mobility-group I	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Calcium-dependent ADP-ribosylation of high-mobility-group_I -LRB- HMGI -RRB- proteins .
12021922	0	HMGI-C	21,27	HMGA2	30,35	HMGI-C	HMGA2	8091	8091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Translocation of the HMGI-C -LRB- HMGA2 -RRB- gene in a benign mesenchymoma -LRB- chondrolipoangioma -RRB- .
9003504	0	HMGI-C	34,40	high_mobility_group_I-C	4,27	HMGI-C	high mobility group I-C	8091	8091	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The high_mobility_group_I-C gene -LRB- HMGI-C -RRB- : polymorphism and genetic localization .
9312114	0	HMGI-C	88,94	raf-1	10,15	HMGI-C	raf-1	8091	5894	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Oncogenic raf-1 induces the expression of non-histone chromosomal architectural protein HMGI-C via a p44/p42 mitogen-activated protein kinase-dependent pathway in salivary epithelial cells .
16279949	0	HMGN1	20,25	N-cadherin	54,64	HMGN1	N-cadherin	15312(Tax:10090)	12558(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Chromosomal protein HMGN1 modulates the expression of N-cadherin .
22393258	0	HMGN1	31,36	PCNA	52,56	HMGN1	PCNA	3150	5111	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin .
21816901	0	HMGN2	0,5	PRLr	64,68	HMGN2	PRLr	3151	5618	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription .
25837481	0	HMGR	89,93	3-hydroxy-3-methylglotaryl-coenzyme_A_reductase	40,87	HMGR	3-hydroxy-3-methylglotaryl-coenzyme A reductase	3159	3159	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Erratum to : Bioinformatics study of the 3-hydroxy-3-methylglotaryl-coenzyme_A_reductase -LRB- HMGR -RRB- gene in Gramineae .
15063128	0	HML-2	35,40	Rec	58,61	HML-2	Rec	10462	58163	Gene	Gene	proviruses|appos|START_ENTITY retrovirus|dobj|proviruses retrovirus|nmod|capacity capacity|compound|END_ENTITY	Human endogenous retrovirus HERV-K -LRB- HML-2 -RRB- proviruses with Rec protein coding capacity and transcriptional activity .
16395745	0	HML-2	35,40	Rec	42,45	HML-2	Rec	10462	58163	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human endogenous retrovirus HERV-K -LRB- HML-2 -RRB- Rec expression and transcriptional activities in normal and rheumatoid_arthritis synovia .
22203674	0	HMMR	116,120	hyaluronan-mediated_motility_receptor	77,114	HMMR	hyaluronan-mediated motility receptor	3161	3161	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mechanism of MTA1 protein overexpression-linked invasion : MTA1 regulation of hyaluronan-mediated_motility_receptor -LRB- HMMR -RRB- expression and function .
24789576	0	HMOX1	18,23	AP-2	57,61	HMOX1	AP-2	3162	7020	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the HMOX1 gene by the transcription factor AP-2 with unique DNA binding site .
18550526	0	HMOX1	33,38	BACH1	0,5	HMOX1	BACH1	3162	571	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	BACH1 is a specific repressor of HMOX1 that is inactivated by arsenite .
25019514	0	HMOX1	31,36	Bach1	72,77	HMOX1	Bach1	3162	571	Gene	Gene	I|appos|START_ENTITY Induction|nmod|I Induction|dep|modulator modulator|nmod|activity activity|amod|END_ENTITY	Induction of heme oxygenase I -LRB- HMOX1 -RRB- by HPP-4382 : a novel modulator of Bach1 activity .
26244607	0	HMOX1	43,48	Bach1	63,68	HMOX1	Bach1	3162	571	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2 : Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line .
26244607	0	HMOX1	43,48	Bach1	63,68	HMOX1	Bach1	3162	571	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Dual regulation of skin sensitizer-induced HMOX1 expression by Bach1 and Nrf2 : Comparison to regulation of the AKR1C2-ARE element in the KeratinoSens cell line .
6455951	0	HMW	53,56	Hageman_factor	15,29	HMW	Hageman factor	57587	2161	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Mechanisms for Hageman_factor activation and role of HMW kininogen as a coagulation cofactor .
16407841	0	HMW-MAA	65,72	high_molecular_weight-melanoma_associated_antigen	14,63	HMW-MAA	high molecular weight-melanoma associated antigen	1464	1464	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of high_molecular_weight-melanoma_associated_antigen -LRB- HMW-MAA -RRB- gene expression by promoter DNA methylation in human melanoma cells .
12610140	0	HN	97,99	hemagglutinin-neuraminidase	68,95	HN	hemagglutinin-neuraminidase	911961(Tax:11216)	911961(Tax:11216)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Triggering of human_parainfluenza_virus_3 fusion protein -LRB- F -RRB- by the hemagglutinin-neuraminidase -LRB- HN -RRB- protein : an HN mutation diminishes the rate of F activation and fusion .
2718627	0	HN	65,67	hemagglutinin-neuraminidase	36,63	HN	hemagglutinin-neuraminidase	1489765(Tax:11161)	1489765(Tax:11161)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Complete nucleotide sequence of the hemagglutinin-neuraminidase -LRB- HN -RRB- mRNA of mumps_virus_and_comparison_of_paramyxovirus_HN_proteins .
7710685	0	HNF-1_alpha	48,59	CYP2E1	81,87	HNF-1 alpha	CYP2E1	24817(Tax:10116)	25086(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of the liver-enriched transcription factor HNF-1_alpha in expression of the CYP2E1 gene .
25744420	0	HNF-1a	99,105	CDX-2	93,98	HNF-1a	CDX-2	24817(Tax:10116)	66019(Tax:10116)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Thyroid and Glucocorticoid Hormones Induce Expression of Lactase-Phlorizin_Hydrolase Gene in CDX-2 / HNF-1a Co-Transfected IEC-6 Cells .
11174836	0	HNF-1alpha	108,118	MODY3	135,140	HNF-1alpha	MODY3	6927	6927	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Counterregulatory responses to hypoglycemia in patients with maturity-onset diabetes_of_the_young caused by HNF-1alpha gene mutations -LRB- MODY3 -RRB- .
19433262	0	HNF-1alpha	66,76	SLC2A2	0,6	HNF-1alpha	SLC2A2	24817(Tax:10116)	25351(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta .
10617683	0	HNF-1alpha	12,22	catalase	46,54	HNF-1alpha	catalase	21405(Tax:10090)	12359(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The role of HNF-1alpha in controlling hepatic catalase activity .
15647252	0	HNF-1beta	45,54	hepatocyte_nuclear_factor-1beta	12,43	HNF-1beta	hepatocyte nuclear factor-1beta	21410(Tax:10090)	21410(Tax:10090)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Role of the hepatocyte_nuclear_factor-1beta -LRB- HNF-1beta -RRB- C-terminal domain in Pkhd1 -LRB- ARPKD -RRB- gene transcription and renal cystogenesis .
17307554	0	HNF-1beta	110,119	hepatocyte_nuclear_factor-1beta	72,103	HNF-1beta	hepatocyte nuclear factor-1beta	6928	6928	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Neonatal cholestatic_jaundice as the first symptom of a mutation in the hepatocyte_nuclear_factor-1beta gene -LRB- HNF-1beta -RRB- .
1350202	0	HNF-3	65,70	BF-1	39,43	HNF-3	BF-1	171302(Tax:10116)	24370(Tax:10116)	Gene	Gene	family|compound|START_ENTITY member|nmod|family expression|appos|member expression|nmod|END_ENTITY	Telencephalon-restricted expression of BF-1 , a new member of the HNF-3 / fork head gene family , in the developing rat brain .
8253274	0	HNF-3_alpha	17,28	XFKH2	0,5	HNF-3 alpha	XFKH2	100125667(Tax:8355)	100125667(Tax:8355)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	XFKH2 , a Xenopus HNF-3_alpha homologue , exhibits both activin-inducible and autonomous phases of expression in early embryos .
12774021	0	HNF-3beta	51,60	Forkhead_box_A2	34,49	HNF-3beta	Forkhead box A2	15376(Tax:10090)	15376(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Elevated hepatocyte levels of the Forkhead_box_A2 -LRB- HNF-3beta -RRB- transcription factor cause postnatal steatosis and mitochondrial_damage .
9408084	0	HNF-4	30,35	Cyp2a-4	77,84	HNF-4	Cyp2a-4	15378(Tax:10090)	13086(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|appos|END_ENTITY	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 -LRB- Cyp2a-4 -RRB- gene in mouse liver .
15831710	0	HNF-4	94,99	intestinal_alkaline_phosphatase	50,81	HNF-4	intestinal alkaline phosphatase	3172	248	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Differentiation-dependent activation of the human intestinal_alkaline_phosphatase promoter by HNF-4 in intestinal cells .
15322103	0	HNF-4	53,58	pregnane_X_receptor	17,36	HNF-4	pregnane X receptor	3172	8856	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	Ligand-activated pregnane_X_receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha .
25043045	0	HNF-4a	20,26	IDH	7,10	HNF-4a	IDH	15378(Tax:10090)	15926(Tax:10090)	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary_cancer .
25607362	0	HNF-4a	33,39	IDH	20,23	HNF-4a	IDH	3172	3417	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Corrigendum : Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary_cancer .
26580013	0	HNF-4a	33,39	IDH	20,23	HNF-4a	IDH	3172	3417	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Corrigendum : Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary_cancer .
27011261	0	HNF-4a	184,190	miR122	191,197	HNF-4a	miR122	15378(Tax:10090)	387231(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4a miR122 Pathway .
22902540	0	HNF-4a	78,84	sex_hormone-binding_globulin	24,52	HNF-4a	sex hormone-binding globulin	3172	6462	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	IL1b down-regulation of sex_hormone-binding_globulin production by decreasing HNF-4a via MEK-1 / 2 and JNK MAPK pathways .
16799975	0	HNF-4alpha	46,56	CAR	101,104	HNF-4alpha	CAR	15378(Tax:10090)	12355(Tax:10090)	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR .
15796896	0	HNF-4alpha	73,83	CYP7A1	102,108	HNF-4alpha	CYP7A1	3172	1581	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Feedback regulation of bile_acid synthesis in human liver : importance of HNF-4alpha for regulation of CYP7A1 .
10866048	0	HNF-4alpha	123,133	MODY1	134,139	HNF-4alpha	MODY1	3172	3172	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Reduced pancreatic_polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha / MODY1 gene .
15503648	0	HNF-4alpha	45,55	PPARalpha	77,86	HNF-4alpha	PPARalpha	3172	5465	Gene	Gene	START_ENTITY|nmod|alternative alternative|nmod|END_ENTITY	Hypolipidemia induced by PPARalpha agonists : HNF-4alpha as an alternative to PPARalpha .
11890664	0	HNF-4alpha	67,77	SHP	25,28	HNF-4alpha	SHP	3172	8431	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells .
8417340	0	HNF1	89,93	LFB1	83,87	HNF1	LFB1	378589(Tax:8355)	378589(Tax:8355)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Developmental regulation and tissue distribution of the liver transcription factor LFB1 -LRB- HNF1 -RRB- in Xenopus_laevis .
1956774	0	HNF1	71,75	aldolase_B	87,97	HNF1	aldolase B	24817(Tax:10116)	24190(Tax:10116)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Interplay of an original combination of factors : C/EBP , NFY , HNF3 , and HNF1 in the rat aldolase_B gene promoter .
7678342	0	HNF1	121,125	insulin-like_growth_factor_binding_protein_1	35,79	HNF1	insulin-like growth factor binding protein 1	6927	3484	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Liver-specific expression of human insulin-like_growth_factor_binding_protein_1 : functional role of transcription factor HNF1 in vivo .
20633866	0	HNF1B	47,52	hepatocyte_nuclear_factor-1b	17,45	HNF1B	hepatocyte nuclear factor-1b	6928	6928	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the hepatocyte_nuclear_factor-1b -LRB- HNF1B -RRB- gene are common with combined uterine and renal malformations but are not found with isolated uterine malformations .
8735941	0	HNF1_alpha	68,78	LFB1	80,84	HNF1 alpha	LFB1	378589(Tax:8355)	378589(Tax:8355)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation and function of the tissue-specific transcription factor HNF1_alpha -LRB- LFB1 -RRB- during Xenopus development .
12488960	0	HNF1_alpha	66,76	MODY3	78,83	HNF1 alpha	MODY3	6927	6927	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a naturally occurring mutation -LRB- L107I -RRB- in the HNF1_alpha -LRB- MODY3 -RRB- gene .
9052741	0	HNF1_alpha	0,10	UGT2B1	57,63	HNF1 alpha	UGT2B1	24817(Tax:10116)	286954(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	HNF1_alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter .
20810608	0	HNF1a	25,30	ClC-5	81,86	HNF1a	ClC-5	21405(Tax:10090)	12728(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The transcription factor HNF1a regulates expression of chloride-proton exchanger ClC-5 in the renal proximal tubule .
24100303	0	HNF1a	25,30	angiotensin-converting_enzyme_2	53,84	HNF1a	angiotensin-converting enzyme 2	6927	59272	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The transcription factor HNF1a induces expression of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- in pancreatic islets from evolutionarily conserved promoter motifs .
23052196	0	HNF1a	55,60	hepatocyte_nuclear_factor_1_and_4_alpha	14,53	HNF1a	hepatocyte nuclear factor 1 and 4 alpha	6927	3172	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of hepatocyte_nuclear_factor_1_and_4_alpha -LRB- HNF1a and HNF4a -RRB- as a mechanism of arsenic_carcinogenesis .
14656222	0	HNF1alpha	0,9	CFTR	55,59	HNF1alpha	CFTR	21405(Tax:10090)	12638(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	HNF1alpha is involved in tissue-specific regulation of CFTR gene expression .
20048381	0	HNF1alpha	50,59	PCSK9	20,25	HNF1alpha	PCSK9	6927	255738	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2 : mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters .
9369482	0	HNF1alpha	12,21	glucose-6-phosphatase	52,73	HNF1alpha	glucose-6-phosphatase	6927	2538	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	The role of HNF1alpha , HNF3gamma , and cyclic_AMP in glucose-6-phosphatase gene activation .
19304666	0	HNF1alpha	104,113	hepassocin	139,149	HNF1alpha	hepassocin	6927	2267	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular_carcinoma .
19304666	0	HNF1alpha	104,113	hepassocin	38,48	HNF1alpha	hepassocin	6927	2267	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular_carcinoma .
10868948	0	HNF3B	137,142	hepatocyte_nuclear_factor-3beta	99,130	HNF3B	hepatocyte nuclear factor-3beta	3170	3170	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Beta-cell transcription factors and diabetes : no evidence for diabetes-associated mutations in the hepatocyte_nuclear_factor-3beta gene -LRB- HNF3B -RRB- in Japanese patients with maturity-onset diabetes_of_the_young .
10868949	0	HNF3B	63,68	hepatocyte_nuclear_factor-3beta	25,56	HNF3B	hepatocyte nuclear factor-3beta	3170	3170	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the hepatocyte_nuclear_factor-3beta gene -LRB- HNF3B -RRB- does not contribute to maturity-onset_diabetes_of_the_young in French Caucasians .
9832509	0	HNF4	16,20	GATA6	0,5	HNF4	GATA6	15378(Tax:10090)	14465(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo .
17827402	0	HNF4A	130,135	hepatocyte_nuclear_factor_4_alpha	95,128	HNF4A	hepatocyte nuclear factor 4 alpha	3172	3172	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte_nuclear_factor_4_alpha -LRB- HNF4A -RRB- P2 region are associated with type 2 diabetes in Scandinavians .
25878394	0	HNF4G	105,110	miR-34a	0,7	HNF4G	miR-34a	3174	407040	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-34a inhibits proliferation and invasion of bladder_cancer cells by targeting orphan nuclear receptor HNF4G .
12107181	0	HNF4_alpha	142,152	PGC-1	16,21	HNF4 alpha	PGC-1	3172	10891	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4_alpha and cAMP-response_element-binding_protein -LRB- CREB -RRB- .
25238230	0	HNF4a	55,60	CYP2E1	13,19	HNF4a	CYP2E1	3172	1571	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	HBx inhibits CYP2E1 gene expression via downregulating HNF4a in human hepatoma cells .
26216285	0	HNF4a	0,5	Claudin-7	16,25	HNF4a	claudin-7	3172	1366	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	HNF4a Regulates Claudin-7 Protein Expression during Intestinal Epithelial Differentiation .
22384829	0	HNF4a	54,59	GSK3b	0,5	HNF4a	GSK3b	3172	2932	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	GSK3b regulates gluconeogenic gene expression through HNF4a and FOXO1 .
22960426	0	HNF4a	15,20	GSK3b	56,61	HNF4a	GSK3b	3172	2932	Gene	Gene	activity|amod|START_ENTITY activity|nmod|inactivation inactivation|amod|END_ENTITY	TGFb overrides HNF4a tumor suppressing activity through GSK3b inactivation : implication for hepatocellular_carcinoma gene therapy .
26232425	0	HNF4a	30,35	IGFBP1	94,100	HNF4a	IGFBP1	3172	3484	Gene	Gene	Gene|compound|START_ENTITY END_ENTITY|nsubj|Gene	Pregnane_X_Receptor Represses HNF4a Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells .
26232425	0	HNF4a	30,35	Pregnane_X_Receptor	0,19	HNF4a	Pregnane X Receptor	3172	8856	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Pregnane_X_Receptor Represses HNF4a Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells .
22308320	0	HNF4a	103,108	Src	0,3	HNF4a	Src	3172	6714	Gene	Gene	loss|nmod|START_ENTITY correlates|nmod|loss correlates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon_cancer .
22308320	0	HNF4a	56,61	Src	0,3	HNF4a	Src	3172	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon_cancer .
21047794	0	HNF4a	59,64	hepatocyte_nuclear_factor-4a	29,57	HNF4a	hepatocyte nuclear factor-4a	3172	3172	Gene	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	Proteomic analysis of native hepatocyte_nuclear_factor-4a -LRB- HNF4a -RRB- isoforms , phosphorylation status , and interactive cofactors .
21241755	0	HNF4a	53,58	miR-122	31,38	HNF4a	miR-122	15378(Tax:10090)	387231(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Positive regulation of hepatic miR-122 expression by HNF4a .
12740371	0	HNF4alpha	39,48	AMP-activated_protein_kinase	0,28	HNF4alpha	AMP-activated protein kinase	3172	5563	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	AMP-activated_protein_kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability .
16826572	0	HNF4alpha	60,69	Snail	0,5	HNF4alpha	Snail	3172	6615	Gene	Gene	expression|amod|START_ENTITY repressing|dobj|expression controls|advcl|repressing controls|nsubj|END_ENTITY	Snail controls differentiation of hepatocytes by repressing HNF4alpha expression .
12110948	0	HNF4alpha	47,56	hepatocyte_nuclear_factor_4alpha	13,45	HNF4alpha	hepatocyte nuclear factor 4alpha	3172	3172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells .
16895524	0	HNF4alpha	99,108	hepatocyte_nuclear_factor_4alpha	65,97	HNF4alpha	hepatocyte nuclear factor 4alpha	3172	3172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tumour suppressor p53 down-regulates the expression of the human hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- gene .
20622021	0	HNF4alpha	88,97	hepatocyte_nuclear_factor_4alpha	54,86	HNF4alpha	hepatocyte nuclear factor 4alpha	3172	3172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	CCAAT/enhancer-binding _ protein_alpha -LRB- C/EBPalpha -RRB- and hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome_P450_2B6 -LRB- CYP2B6 -RRB- gene : application to the development of a metabolically competent human hepatic cell model .
16479620	0	HNF4alpha	8,17	iNOS	66,70	HNF4alpha	iNOS	3172	4843	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress .
11994307	1	HNF4alpha	117,126	ornithine_transcarbamylase	137,163	HNF4alpha	ornithine transcarbamylase	15378(Tax:10090)	18416(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HNF4alpha regulates ornithine_transcarbamylase in vivo .
6207141	0	HNK-1	23,28	Leu_7	16,21	HNK-1	Leu 7	27087	27087	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Distribution of Leu_7 -LRB- HNK-1 -RRB- antigen in human digestive organs : an immunohistochemical study with monoclonal antibody .
6344083	0	HNK-1	105,110	Leu_7	98,103	HNK-1	Leu 7	27087	27087	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Fluorescence-activated cell sorting of mouse-human hybrid cells aids in locating the gene for the Leu_7 -LRB- HNK-1 -RRB- antigen to human chromosome 11 .
6196641	0	HNK-1	73,78	myelin-associated_glycoprotein	15,45	HNK-1	myelin-associated glycoprotein	27087	4099	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of myelin-associated_glycoprotein by the monoclonal antibody HNK-1 .
15341523	0	HNK-1	113,118	receptor_for_advanced_glycation_end_products	28,72	HNK-1	receptor for advanced glycation end products	76898(Tax:10090)	11596(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- , amphoterin and sulfoglucuronyl -LRB- HNK-1 -RRB- carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration .
2852081	0	HNK1	43,47	Leu_7	50,55	HNK1	Leu 7	27087	27087	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Flow cytometric and morphologic studies of HNK1 + -LRB- Leu_7 + -RRB- lymphocytes in relation to cytomegalovirus carrier status .
26206890	0	HNMT	53,57	Histamine_N-Methyltransferase	17,46	HNMT	Histamine N-Methyltransferase	3176	3176	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the Histamine_N-Methyltransferase gene , HNMT , are Associated with Non-Syndromic Autosomal Recessive Intellectual Disability .
26206890	0	HNMT	53,57	Histamine_N-Methyltransferase	17,46	HNMT	Histamine N-Methyltransferase	3176	3176	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the Histamine_N-Methyltransferase gene , HNMT , are Associated with Non-Syndromic Autosomal Recessive Intellectual Disability .
1530666	0	HNMT	45,49	histamine-N-methyltransferase	14,43	HNMT	histamine-N-methyltransferase	81676(Tax:10116)	81676(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of histamine-N-methyltransferase -LRB- HNMT -RRB- by fragments of 9-amino-1 ,2,3,4 - tetrahydroacridine -LRB- tacrine -RRB- and by beta-carbolines .
16205835	0	HNMT	54,58	histamine-N-methyltransferase	23,52	HNMT	histamine-N-methyltransferase	3176	3176	Gene	Gene	Lack|appos|START_ENTITY Lack|nmod|association association|nmod|END_ENTITY	Lack of association of histamine-N-methyltransferase -LRB- HNMT -RRB- polymorphisms with asthma in the Indian population .
1968337	0	HNMT	45,49	histamine_N-methyltransferase	14,43	HNMT	histamine N-methyltransferase	3176	3176	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of histamine_N-methyltransferase -LRB- HNMT -RRB- in vitro by neuromuscular relaxants .
8339926	0	HNMT	84,88	histamine_N-methyltransferase	53,82	HNMT	histamine N-methyltransferase	3176	3176	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Genetic segregation analysis of red blood cell -LRB- RBC -RRB- histamine_N-methyltransferase -LRB- HNMT -RRB- activity .
1421280	0	HNP-1	27,32	tumor_necrosis_factor-alpha	54,81	HNP-1	tumor necrosis factor-alpha	574045	7124	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- Effects of human defensin HNP-1 on the production of tumor_necrosis_factor-alpha by human blood monocytes in vitro -RSB- .
7726159	0	HNPCC	33,38	hMSH2	23,28	HNPCC	hMSH2	4292	4436	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Seven new mutations in hMSH2 , an HNPCC gene , identified by denaturing gradient-gel electrophoresis .
25777416	0	HNRNP_G	0,7	estrogen_receptor_alpha	33,56	HNRNP G	estrogen receptor alpha	3186	2099	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	HNRNP_G and HTRA2-BETA1 regulate estrogen_receptor_alpha expression with potential impact on endometrial_cancer .
25884434	0	HNRNP_G	0,7	estrogen_receptor_alpha	33,56	HNRNP G	estrogen receptor alpha	3186	2099	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	HNRNP_G and HTRA2-BETA1 regulate estrogen_receptor_alpha expression with potential impact on endometrial_cancer .
1733858	0	HNRPA1	73,79	heterogeneous_nuclear_ribonucleoprotein_A1	24,66	HNRPA1	heterogeneous nuclear ribonucleoprotein A1	3178	3178	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human heterogeneous_nuclear_ribonucleoprotein_A1 gene -LRB- HNRPA1 -RRB- to chromosome 12q13 .1 by cDNA competitive in situ hybridization .
17600318	0	HO-1	13,17	BMP4	0,4	HO-1	BMP4	3162	652	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	BMP4 induces HO-1 via a Smad-independent , p38MAPK-dependent pathway in pulmonary artery myocytes .
19874887	0	HO-1	66,70	Bach1	11,16	HO-1	Bach1	3162	571	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A role for Bach1 and HO-2 in suppression of basal and UVA-induced HO-1 expression in human keratinocytes .
18992713	0	HO-1	57,61	COX-2	23,28	HO-1	COX-2	24451(Tax:10116)	26198(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	The obligatory role of COX-2 expression for induction of HO-1 in ischemic preconditioned rat brain .
21721581	0	HO-1	59,63	Caveolin-1	0,10	HO-1	Caveolin-1	3162	857	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Caveolin-1 is a competitive inhibitor of heme_oxygenase-1 -LRB- HO-1 -RRB- with heme : identification of a minimum sequence in caveolin-1 for binding to HO-1 .
15993334	0	HO-1	14,18	ERK	45,48	HO-1	ERK	3162	5594	Gene	Gene	increases|dobj|START_ENTITY increases|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells .
19686811	0	HO-1	55,59	ERK	79,82	HO-1	ERK	3162	5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Quercetin-3-O-beta-d-glucuronopyranoside -LRB- QGC -RRB- - induced HO-1 expression through ERK and PI3K activation in cultured feline esophageal epithelial cells .
23569422	0	HO-1	94,98	ERK	107,110	HO-1	ERK	3162	5594	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Propofol-induced protection of SH-SY5Y cells against hydrogen_peroxide is associated with the HO-1 via the ERK pathway .
25007817	0	HO-1	14,18	ERK	46,49	HO-1	ERK	3162	5594	Gene	Gene	induction|compound|START_ENTITY induction|acl|coupled coupled|nmod|END_ENTITY	Nrf2-mediated HO-1 induction coupled with the ERK signaling pathway contributes to indirect antioxidant capacity of caffeic_acid_phenethyl_ester in HepG2 cells .
21307400	0	HO-1	19,23	FLIP	0,4	HO-1	FLIP	3162	8837	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	FLIP regulation of HO-1 and TNF signalling in human acute_myeloid_leukemia provides a unique secondary anti-apoptotic mechanism .
20833713	0	HO-1	16,20	HIF-1alpha	62,72	HO-1	HIF-1alpha	24451(Tax:10116)	29560(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression .
7720678	0	HO-1	56,60	HO-2	30,34	HO-1	HO-2	24451(Tax:10116)	79239(Tax:10116)	Gene	Gene	constitutive|appos|START_ENTITY constitutive|appos|END_ENTITY	Distribution of constitutive -LRB- HO-2 -RRB- and heat-inducible -LRB- HO-1 -RRB- heme oxygenase isozymes in rat testes : HO-2 displays stage-specific expression in germ cells .
24224047	0	HO-1	18,22	Heme_oxygenase-1	0,16	HO-1	Heme oxygenase-1	3162	3162	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Heme_oxygenase-1 -LRB- HO-1 -RRB- expression in prostate_cancer cells modulates the oxidative response in bone cells .
8738152	0	HO-1	18,22	Heme_oxygenase-1	0,16	HO-1	Heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Heme_oxygenase-1 -LRB- HO-1 -RRB- protein induction in rat brain following focal ischemia .
24152841	0	HO-1	33,37	INOS	38,42	HO-1	INOS	3162	4843	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|END_ENTITY	Negative feedback interaction of HO-1 / INOS in PBMC of acute congestive heart_failure patients .
21985290	0	HO-1	121,125	JNK	100,103	HO-1	JNK	15368(Tax:10090)	26419(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute_hepatic_injury through JNK pathway-mediated HO-1 expression .
24366007	0	HO-1	17,21	JNK	47,50	HO-1	JNK	3162	5599	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|advcl|activating activating|dobj|END_ENTITY	Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53 .
16962933	0	HO-1	22,26	NF-E2-related_factor_2	75,97	HO-1	NF-E2-related factor 2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related_factor_2 in PC12 cells .
25431258	0	HO-1	108,112	NRF-2	102,107	HO-1	NRF-2	3162	4780	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Glucose-regulated_protein_78 -LRB- GRP78 -RRB- regulates colon_cancer metastasis through EMT biomarkers and the NRF-2 / HO-1 pathway .
23253326	0	HO-1	68,72	NRF2	0,4	HO-1	NRF2	3162	4780	Gene	Gene	upregulation|nmod|START_ENTITY involved|nmod|upregulation involved|nsubjpass|activation activation|compound|END_ENTITY	NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells .
21622902	0	HO-1	40,44	Nrf-2	0,5	HO-1	Nrf-2	3162	4780	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nrf-2 regulates cyclosporine-stimulated HO-1 expression in gingiva .
22484158	0	HO-1	135,139	Nrf-2	140,145	HO-1	Nrf-2	3162	4780	Gene	Gene	genes|compound|START_ENTITY genes|amod|antioxidant antioxidant|amod|END_ENTITY	Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1 / Nrf-2 antioxidant genes .
23131562	0	HO-1	76,80	Nrf-2	70,75	HO-1	Nrf-2	3162	4780	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	Omega-3_polyunsaturated_fatty_acid has an anti-oxidant effect via the Nrf-2 / HO-1 pathway in 3T3-L1 adipocytes .
23311701	0	HO-1	78,82	Nrf-2	72,77	HO-1	Nrf-2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2 / HO-1 pathway .
23816986	0	HO-1	18,22	Nrf-2	23,28	HO-1	Nrf-2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|parataxis|contributes contributes|nsubj|END_ENTITY	The activation of HO-1 / Nrf-2 contributes to the protective effects of diallyl_disulfide -LRB- DADS -RRB- against ethanol-induced oxidative stress .
24051194	0	HO-1	114,118	Nrf-2	108,113	HO-1	Nrf-2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Diallyl-disulfide , an organosulfur compound of garlic , attenuates airway inflammation via activation of the Nrf-2 / HO-1 pathway and NF-kappaB suppression .
26525667	0	HO-1	104,108	Nrf-2	109,114	HO-1	Nrf-2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY model|nmod|activation extra|nmod|model pathway|dep|extra pathway|compound|END_ENTITY	Dietary extra virgin olive oil attenuates kidney_injury in pristane-induced SLE model via activation of HO-1 / Nrf-2 antioxidant pathway and suppression of JAK/STAT , NF-kB and MAPK activation .
16356129	0	HO-1	43,47	Nrf2	100,104	HO-1	Nrf2	3162	4780	Gene	Gene	expression|compound|START_ENTITY enhancing|dobj|expression enhancing|nmod|END_ENTITY	Molecular mechanisms involved in enhancing HO-1 expression : de-repression by heme and activation by Nrf2 , the `` one-two '' punch .
16923960	0	HO-1	48,52	Nrf2	20,24	HO-1	Nrf2	3162	4780	Gene	Gene	induction|compound|START_ENTITY mediate|dobj|induction interacts|xcomp|mediate interacts|nmod|END_ENTITY	BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress .
18404528	0	HO-1	56,60	Nrf2	23,27	HO-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY roles|nmod|expression roles|nmod|END_ENTITY	Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts .
19445907	0	HO-1	48,52	Nrf2	42,46	HO-1	Nrf2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Curcumin upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
19590705	0	HO-1	45,49	Nrf2	29,33	HO-1	Nrf2	3162	4780	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|appos|Expression	Taurine_Chloramine Activates Nrf2 , Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen_Peroxide .
20227863	0	HO-1	13,17	Nrf2	106,110	HO-1	Nrf2	513221(Tax:9913)	497024(Tax:9913)	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|role role|nmod|END_ENTITY	Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products : a role for Nrf2 in vascular protection in diabetes .
21443188	0	HO-1	13,17	Nrf2	74,78	HO-1	Nrf2	3162	4780	Gene	Gene	expression|compound|START_ENTITY mediated|nsubjpass|expression mediated|nmod|regulation regulation|nmod|END_ENTITY	tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1 .
21443188	0	HO-1	139,143	Nrf2	74,78	HO-1	Nrf2	3162	4780	Gene	Gene	region|nmod|START_ENTITY binding|nmod|region END_ENTITY|amod|binding	tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1 .
23571756	0	HO-1	64,68	Nrf2	0,4	HO-1	Nrf2	3162	4780	Gene	Gene	promoter|compound|START_ENTITY formation|nmod|promoter associated|nmod|formation associated|nsubjpass|activation activation|amod|END_ENTITY	Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter .
24009858	0	HO-1	56,60	Nrf2	90,94	HO-1	Nrf2	3162	4780	Gene	Gene	Hemoxygenase-1|appos|START_ENTITY Hemoxygenase-1|appos|END_ENTITY	Finasteride Increases the Expression of Hemoxygenase-1 -LRB- HO-1 -RRB- and NF-E2-Related_Factor-2 -LRB- Nrf2 -RRB- Proteins in PC-3 Cells : Implication of Finasteride-Mediated High-Grade Prostate_Tumor Occurrence .
24252362	0	HO-1	48,52	Nrf2	42,46	HO-1	Nrf2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Bicyclol upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
25014792	0	HO-1	39,43	Nrf2	121,125	HO-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	Heme_Oxygenase-1|appos|START_ENTITY Transfer|nmod|Heme_Oxygenase-1 Transfer|dep|Rescues Rescues|dep|Nuclear_Factor_Erythroid_2-Related_Factor Nuclear_Factor_Erythroid_2-Related_Factor|appos|END_ENTITY	Adoptive Transfer of Heme_Oxygenase-1 -LRB- HO-1 -RRB- - Modified Macrophages Rescues the Nuclear_Factor_Erythroid_2-Related_Factor -LRB- Nrf2 -RRB- Antiinflammatory Phenotype in Liver_Ischemia / Reperfusion Injury .
25107906	0	HO-1	26,30	Nrf2	85,89	HO-1	Nrf2	3162	4780	Gene	Gene	Heme_Oxygenase-1|appos|START_ENTITY Modulates|nsubj|Heme_Oxygenase-1 Modulates|dobj|Distribution Distribution|nmod|END_ENTITY	Nuclear Heme_Oxygenase-1 -LRB- HO-1 -RRB- Modulates Subcellular Distribution and Activation of Nrf2 , Impacting Metabolic and Anti-oxidant Defenses .
25213834	0	HO-1	33,37	Nrf2	112,116	HO-1	Nrf2	3162	4780	Gene	Gene	Induction|compound|START_ENTITY Development|nmod|Induction Development|nmod|END_ENTITY	Development of Refractoriness of HO-1 Induction to a Second Treatment with UVA Radiation and the Involvement of Nrf2 in Human Skin Fibroblasts .
21763292	0	HO-1	34,38	PI3K	54,58	HO-1	PI3K	15368(Tax:10090)	18708(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	b - adrenergic receptor-mediated HO-1 induction , via PI3K and p38_MAPK , by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice .
18634870	0	HO-1	0,4	STAT-1	15,21	HO-1	STAT-1	15368(Tax:10090)	20846(Tax:10090)	Gene	Gene	signals|amod|START_ENTITY signals|compound|END_ENTITY	HO-1 and JAK-2 / STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline_alkaloid , CKD712 , in cells activated with lipopolysacchride .
12540779	0	HO-1	74,78	Stat4	0,5	HO-1	Stat4	15368(Tax:10090)	20849(Tax:10090)	Gene	Gene	dependence|compound|START_ENTITY END_ENTITY|dep|dependence	Stat4 and Stat6 signaling in hepatic_ischemia / reperfusion injury in mice : HO-1 dependence of Stat4 disruption-mediated cytoprotection .
21620381	0	HO-1	109,113	TAR_DNA-binding_protein-43	66,92	HO-1	TAR DNA-binding protein-43	3162	23435	Gene	Gene	increase|nmod|START_ENTITY END_ENTITY|nmod|increase	MG132 enhances neurite outgrowth in neurons overexpressing mutant TAR_DNA-binding_protein-43 via increase of HO-1 .
12376363	0	HO-1	21,25	TGF-beta1	0,9	HO-1	TGF-beta1	3162	7040	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	TGF-beta1 stimulates HO-1 via the p38_mitogen-activated_protein_kinase in A549 pulmonary epithelial cells .
21315065	0	HO-1	49,53	THP-1	89,94	HO-1	THP-1	3162	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|monocytes monocytes|compound|END_ENTITY	Lipoic_acid ameliorates arsenic_trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages .
12918124	0	HO-1	26,30	TNF-alpha	66,75	HO-1	TNF-alpha	15368(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	TLR4 mediates LPS-induced HO-1 expression in mouse liver : role of TNF-alpha and IL-1beta .
15050899	0	HO-1	73,77	VEGF	67,71	HO-1	VEGF	24451(Tax:10116)	83785(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Activation of the transcription factor HIF-1 and its target genes , VEGF , HO-1 , iNOS , during fracture repair .
15596152	0	HO-1	80,84	VEGF	54,58	HO-1	VEGF	15368(Tax:10090)	22339(Tax:10090)	Gene	Gene	knockout|compound|START_ENTITY effect|nmod|knockout Role|dep|effect Role|nmod|synthesis synthesis|amod|heme_oxygenase-1 heme_oxygenase-1|nmod|END_ENTITY	Role of heme_oxygenase-1 in hydrogen_peroxide-induced VEGF synthesis : effect of HO-1 knockout .
18937073	0	HO-1	35,39	VEGF	74,78	HO-1	VEGF	24451(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|upregulation upregulation|nmod|levels levels|compound|END_ENTITY	Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells .
23088309	0	HO-1	127,131	VEGF	114,118	HO-1	VEGF	15368(Tax:10090)	22339(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY producing|nmod|induction producing|dobj|END_ENTITY	-LRB- S -RRB- -1 - a-naphthylmethyl-6 ,7 - dihydroxy-1 ,2,3,4 - tetrahydroisoquinoline -LRB- CKD712 -RRB- , promotes wound closure by producing VEGF through HO-1 induction in human dermal fibroblasts and mouse skin .
21721581	0	HO-1	142,146	caveolin-1	116,126	HO-1	caveolin-1	3162	857	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|nmod|binding	Caveolin-1 is a competitive inhibitor of heme_oxygenase-1 -LRB- HO-1 -RRB- with heme : identification of a minimum sequence in caveolin-1 for binding to HO-1 .
15932518	0	HO-1	41,45	haem-oxygenase-1	23,39	HO-1	haem-oxygenase-1	3162	3162	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of intestinal haem-oxygenase-1 -LRB- HO-1 -RRB- in clinical and experimental colitis .
23139759	0	HO-1	33,37	heme-oxygenase-1	15,31	HO-1	heme-oxygenase-1	3162	3162	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Maternal serum heme-oxygenase-1 -LRB- HO-1 -RRB- concentrations in early pregnancy and subsequent risk of gestational_diabetes_mellitus .
12835107	0	HO-1	79,83	heme_oxygenase	23,37	HO-1	heme oxygenase	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|parataxis|START_ENTITY Induction|nmod|END_ENTITY	Induction of inducible heme_oxygenase -LRB- HO-1 -RRB- in the central nervous system : is HO-1 helpful or harmful ?
10413312	0	HO-1	57,61	heme_oxygenase-1	39,55	HO-1	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Coordinate up-regulation of CYP1A1 and heme_oxygenase-1 -LRB- HO-1 -RRB- expression and modulation of delta-aminolevulinic_acid synthase and tryptophan_pyrrolase activities in pyridine-treated rats .
11751428	0	HO-1	33,37	heme_oxygenase-1	15,31	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of heme_oxygenase-1 -LRB- HO-1 -RRB- in the adaptive protection of human lymphocytes after hyperbaric oxygen -LRB- HBO -RRB- treatment .
11948696	0	HO-1	49,53	heme_oxygenase-1	31,47	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Functional expression of human heme_oxygenase-1 -LRB- HO-1 -RRB- driven by HO-1 promoter in vitro and in vivo .
15081633	0	HO-1	50,54	heme_oxygenase-1	32,48	HO-1	heme oxygenase-1	15368(Tax:10090)	15368(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Marked developmental changes in heme_oxygenase-1 -LRB- HO-1 -RRB- expression in the mouse placenta : correlation between HO-1 expression and placental development .
15365571	0	HO-1	34,38	heme_oxygenase-1	16,32	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Polymorphism in heme_oxygenase-1 -LRB- HO-1 -RRB- promoter is related to the risk of oral_squamous_cell_carcinoma occurring on male areca chewers .
17486279	0	HO-1	32,36	heme_oxygenase-1	14,30	HO-1	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Assessment of heme_oxygenase-1 -LRB- HO-1 -RRB- activity in the cavernous tissues of sildenafil_citrate-treated rats .
17657593	0	HO-1	109,113	heme_oxygenase-1	91,107	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Structural influence of isothiocyanates on the antioxidant response element -LRB- ARE -RRB- - mediated heme_oxygenase-1 -LRB- HO-1 -RRB- expression .
19475336	0	HO-1	38,42	heme_oxygenase-1	20,36	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Genetic analysis of heme_oxygenase-1 -LRB- HO-1 -RRB- in German Parkinson 's _ disease patients .
19833168	0	HO-1	36,40	heme_oxygenase-1	18,34	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Rottlerin induces heme_oxygenase-1 -LRB- HO-1 -RRB- up-regulation through reactive oxygen species -LRB- ROS -RRB- dependent and PKC_delta-independent pathway in human colon_cancer HT29 cells .
19895178	0	HO-1	34,38	heme_oxygenase-1	16,32	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Polymorphism in heme_oxygenase-1 -LRB- HO-1 -RRB- promoter and alcohol are related to the risk of esophageal_squamous_cell_carcinoma on Chinese males .
21327520	0	HO-1	52,56	heme_oxygenase-1	34,50	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Ferrearin_C induces apoptosis via heme_oxygenase-1 -LRB- HO-1 -RRB- induction in neuroblastoma .
22158875	0	HO-1	49,53	heme_oxygenase-1	31,47	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-19 -LRB- IL-19 -RRB- induces heme_oxygenase-1 -LRB- HO-1 -RRB- expression and decreases reactive oxygen species in human vascular smooth muscle cells .
23746277	0	HO-1	29,33	heme_oxygenase-1	11,27	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	A focus on heme_oxygenase-1 -LRB- HO-1 -RRB- inhibitors .
8584240	0	HO-1	31,35	heme_oxygenase-1	13,29	HO-1	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HO-1 -RRB- after traumatic brain_injury in the rat .
8930310	0	HO-1	31,35	heme_oxygenase-1	13,29	HO-1	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HO-1 -RRB- in glia after traumatic_brain_injury .
9622586	0	HO-1	31,35	heme_oxygenase-1	13,29	HO-1	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HO-1 -RRB- in the contused spinal cord of the rat .
9890653	0	HO-1	63,67	heme_oxygenase-1	45,61	HO-1	heme oxygenase-1	3162	3162	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the antioxidant stress protein heme_oxygenase-1 -LRB- HO-1 -RRB- in human leukocytes .
26488466	0	HO-1	36,40	heme_oxygenase_1	18,34	HO-1	heme oxygenase 1	3162	3162	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Downregulation of heme_oxygenase_1 -LRB- HO-1 -RRB- activity in hematopoietic cells enhances their engraftment after transplantation .
15050899	0	HO-1	73,77	iNOS	79,83	HO-1	iNOS	24451(Tax:10116)	24599(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Activation of the transcription factor HIF-1 and its target genes , VEGF , HO-1 , iNOS , during fracture repair .
15498032	0	HO-1	22,26	iNOS	72,76	HO-1	iNOS	15368(Tax:10090)	18126(Tax:10090)	Gene	Gene	suppresses|compound|START_ENTITY induction|nmod|suppresses lupus_nephritis|nsubj|induction lupus_nephritis|advcl|reducing reducing|dobj|END_ENTITY	Chemical induction of HO-1 suppresses lupus_nephritis by reducing local iNOS expression and synthesis of anti-dsDNA antibody .
15740980	0	HO-1	19,23	iNOS	118,122	HO-1	iNOS	3162	51477	Gene	Gene	Super-induction|nmod|START_ENTITY END_ENTITY|nsubj|Super-induction	Super-induction of HO-1 in macrophages stimulated with lipopolysaccharide by prior depletion of glutathione decreases iNOS expression and NO production .
18634870	0	HO-1	0,4	iNOS	73,77	HO-1	iNOS	15368(Tax:10090)	18126(Tax:10090)	Gene	Gene	signals|amod|START_ENTITY involved|nsubjpass|signals involved|nmod|inhibition inhibition|nmod|END_ENTITY	HO-1 and JAK-2 / STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline_alkaloid , CKD712 , in cells activated with lipopolysacchride .
18434445	0	HO-1	117,121	p38	82,85	HO-1	p38	24451(Tax:10116)	81649(Tax:10116)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage : p38 MAPK-dependent upregulation of HO-1 .
12376363	0	HO-1	21,25	p38_mitogen-activated_protein_kinase	34,70	HO-1	p38 mitogen-activated protein kinase	3162	1432	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	TGF-beta1 stimulates HO-1 via the p38_mitogen-activated_protein_kinase in A549 pulmonary epithelial cells .
7720678	0	HO-2	30,34	HO-1	56,60	HO-2	HO-1	79239(Tax:10116)	24451(Tax:10116)	Gene	Gene	constitutive|appos|START_ENTITY constitutive|appos|END_ENTITY	Distribution of constitutive -LRB- HO-2 -RRB- and heat-inducible -LRB- HO-1 -RRB- heme oxygenase isozymes in rat testes : HO-2 displays stage-specific expression in germ cells .
22304481	0	HO2	58,61	HO2	64,67	HO2	HO2	3163	3163	Gene	Gene	reaction|compound|START_ENTITY reaction|compound|END_ENTITY	Theoretical determination of the rate coefficient for the HO2 + HO2 > H2O2 + O2 reaction : adiabatic treatment of anharmonic torsional effects .
22304481	0	HO2	64,67	HO2	58,61	HO2	HO2	3163	3163	Gene	Gene	reaction|compound|START_ENTITY reaction|compound|END_ENTITY	Theoretical determination of the rate coefficient for the HO2 + HO2 > H2O2 + O2 reaction : adiabatic treatment of anharmonic torsional effects .
17386922	0	HOMER2	0,6	MYO18B	13,19	HOMER2	MYO18B	9455	84700	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth .
12860370	0	HOPA	72,76	human_opposite_paired	49,70	HOPA	human opposite paired	9968	9968	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association of a dodecamer duplication in the human_opposite_paired -LRB- HOPA -RRB- gene with mental_retardation and schizophrenia in Chinese patients from Taiwan .
22958219	0	HOPX	71,75	HOP_homeobox	57,69	HOPX	HOP homeobox	84525	84525	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cancer specific promoter CpG Islands hypermethylation of HOP_homeobox -LRB- HOPX -RRB- gene and its potential tumor suppressive role in pancreatic carcinogenesis .
22958219	0	HOP_homeobox	57,69	HOPX	71,75	HOP homeobox	HOPX	84525	84525	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cancer specific promoter CpG Islands hypermethylation of HOP_homeobox -LRB- HOPX -RRB- gene and its potential tumor suppressive role in pancreatic carcinogenesis .
22776561	0	HORMAD1	62,69	HORMA_domain_containing_protein_1	27,60	HORMAD1	HORMA domain containing protein 1	84072	84072	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Biological significance of HORMA_domain_containing_protein_1 -LRB- HORMAD1 -RRB- in epithelial_ovarian_carcinoma .
22776561	0	HORMA_domain_containing_protein_1	27,60	HORMAD1	62,69	HORMA domain containing protein 1	HORMAD1	84072	84072	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Biological significance of HORMA_domain_containing_protein_1 -LRB- HORMAD1 -RRB- in epithelial_ovarian_carcinoma .
25619693	0	HOS1	0,4	Argonaute1	15,25	HOS1	Argonaute1	818568(Tax:3702)	841262(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HOS1 regulates Argonaute1 by promoting transcription of the microRNA gene MIR168b in Arabidopsis .
26111795	0	HOTAIR	38,44	BRD4	24,28	HOTAIR	BRD4	100124700	23476	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	The Bromodomain protein BRD4 controls HOTAIR , a long noncoding RNA essential for glioblastoma proliferation .
26187665	0	HOTAIR	20,26	HLA-G	36,41	HOTAIR	HLA-G	100124700	3135	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Long non-coding RNA HOTAIR promotes HLA-G expression via inhibiting miR-152 in gastric_cancer cells .
24999034	0	HOTAIR	39,45	Osteopontin	0,11	HOTAIR	Osteopontin	100124700	6696	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Osteopontin enhances the expression of HOTAIR in cancer cells via IRF1 .
24118380	0	HOTAIR	0,6	WIF-1	76,81	HOTAIR	WIF-1	100124700	11197	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	HOTAIR , a prognostic factor in esophageal_squamous_cell_carcinoma , inhibits WIF-1 expression and activates Wnt pathway .
26482614	0	HOTAIR	24,30	Wnt_inhibitory_factor_1	128,151	HOTAIR	Wnt inhibitory factor 1	100124700	11197	Gene	Gene	affects|nsubj|START_ENTITY affects|advcl|regulating regulating|dobj|expression expression|nmod|END_ENTITY	The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic_ductal_adenocarcinoma by regulating the expression of Wnt_inhibitory_factor_1 .
25979172	0	HOTAIR	20,26	c-KIT	37,42	HOTAIR	c-KIT	100124700	3815	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute_myeloid_leukemia .
26469956	0	HOTAIR	20,26	cyclin_J	37,45	HOTAIR	cyclin J	100124700	54619	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Long non-coding RNA HOTAIR regulates cyclin_J via inhibition of microRNA-205 expression in bladder_cancer .
24616104	0	HOTAIR	20,26	miR-141	56,63	HOTAIR	miR-141	100124700	406933	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells .
24953832	0	HOTAIR	20,26	miRNA-130a	89,99	HOTAIR	miRNA-130a	100124700	406919	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Long non-coding RNA HOTAIR , a c-Myc activated driver of malignancy , negatively regulates miRNA-130a in gallbladder_cancer .
25779149	0	HOTTIP	24,30	HOXA13	93,99	HOTTIP	HOXA13	100316868	3209	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic_cancer .
25889214	0	HOTTIP	24,30	HOXA13	93,99	HOTTIP	HOXA13	100316868	3209	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic_cancer .
25889214	0	HOTTIP	24,30	HOXA13	93,99	HOTTIP	HOXA13	100316868	3209	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic_cancer .
23900545	0	HOX	45,48	Utx	31,34	HOX	Utx	42536(Tax:7227)	34377(Tax:7227)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner .
9819390	0	HOX11	29,34	Aldh1	45,50	HOX11	Aldh1	15404(Tax:10090)	11668(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development .
10327073	0	HOX11	0,5	CTF1	21,25	HOX11	CTF1	3204	1489	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization .
9009195	0	HOX11	0,5	PP2A	42,46	HOX11	PP2A	373832(Tax:8355)	399328(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint .
7908826	0	HOX11	78,83	Tlx-1	49,54	HOX11	Tlx-1	21908(Tax:10090)	21908(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Characterization and developmental expression of Tlx-1 , the murine homolog of HOX11 .
12661009	0	HOX11L2	14,21	BCL11B	47,53	HOX11L2	BCL11B	30012	64919	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of HOX11L2 by juxtaposition with 3 ' - BCL11B in an acute_lymphoblastic_leukemia cell line -LRB- HPB-ALL -RRB- with t -LRB- 5 ; 14 -RRB- -LRB- q35 ; q32 .2 -RRB- .
19821827	0	HOX11L2	30,37	TLX3	24,28	HOX11L2	TLX3	30012	30012	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Prognostic relevance of TLX3 -LRB- HOX11L2 -RRB- expression in childhood_T-cell_acute_lymphoblastic_leukaemia treated with Berlin-Frankfurt-M __ nster -LRB- BFM -RRB- protocols containing early and late re-intensification elements .
21744064	0	HOX11L2	86,93	Tlx3	80,84	HOX11L2	Tlx3	30012	30012	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Hes-1 regulates the excitatory fate of neural progenitors through modulation of Tlx3 -LRB- HOX11L2 -RRB- expression .
7742539	0	HOX4A	22,27	HOXD3	29,34	HOX4A	HOXD3	3232	3232	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Overexpression of the HOX4A -LRB- HOXD3 -RRB- homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties .
9324017	0	HOX4C	34,39	basic_fibroblast_growth_factor	48,78	HOX4C	basic fibroblast growth factor	3235	2247	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the HOX4C gene by basic_fibroblast_growth_factor on rheumatoid synovial fibroblasts .
12112533	0	HOXA	115,119	HOXA13	134,140	HOXA	HOXA13	3197	3209	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The chromosome translocation t -LRB- 7 ; 11 -RRB- -LRB- p15 ; p15 -RRB- in acute_myeloid_leukemia results in fusion of the NUP98 gene with a HOXA cluster gene , HOXA13 , but not HOXA9 .
12112533	0	HOXA	115,119	NUP98	97,102	HOXA	NUP98	3197	4928	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	The chromosome translocation t -LRB- 7 ; 11 -RRB- -LRB- p15 ; p15 -RRB- in acute_myeloid_leukemia results in fusion of the NUP98 gene with a HOXA cluster gene , HOXA13 , but not HOXA9 .
23534758	0	HOXA1	54,59	Let-7c	0,6	HOXA1	Let-7c	3198	406885	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Let-7c inhibits NSCLC cell proliferation by targeting HOXA1 .
19778996	0	HOXA10	60,66	3-Phosphoglycerate_dehydrogenase	0,32	HOXA10	3-Phosphoglycerate dehydrogenase	15395(Tax:10090)	236539(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	3-Phosphoglycerate_dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells .
21471217	0	HOXA10	55,61	CDX4	17,21	HOXA10	CDX4	3206	1046	Gene	Gene	transcription|nummod|START_ENTITY activates|dobj|transcription activates|nsubj|transcription transcription|compound|END_ENTITY	HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells .
26478432	0	HOXA10	26,32	CTCF	0,4	HOXA10	CTCF	3206	10664	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CTCF negatively regulates HOXA10 expression in breast_cancer cells .
24532216	0	HOXA10	0,6	Cytokeratin_15	31,45	HOXA10	Cytokeratin 15	3206	3866	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	HOXA10 Regulates Expression of Cytokeratin_15 in Endometrial Epithelial Cytoskeletal Remodeling .
20371740	0	HOXA10	60,66	Endothelin_type_A_receptor	0,26	HOXA10	Endothelin type A receptor	3206	1909	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Endothelin_type_A_receptor -LRB- ETA -RRB- expression is regulated by HOXA10 in human endometrial stromal cells .
22279148	0	HOXA10	22,28	FKBP4	0,5	HOXA10	FKBP4	3206	2288	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	FKBP4 is regulated by HOXA10 during decidualization and in endometriosis .
21471217	0	HOXA10	55,61	HoxA10	0,6	HOXA10	HoxA10	3206	3206	Gene	Gene	transcription|nummod|START_ENTITY activates|dobj|transcription activates|nsubj|transcription transcription|compound|END_ENTITY	HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells .
20463357	0	HOXA10	0,6	Kruppel-like_factor_9	16,37	HOXA10	Kruppel-like factor 9	3206	687	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	HOXA10 inhibits Kruppel-like_factor_9 expression in the human endometrial epithelium .
16551735	0	HOXA10	40,46	Thrombin	0,8	HOXA10	Thrombin	3206	2147	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells : implications for preterm_labor .
25500095	0	HOXA10	18,24	miR-494	0,7	HOXA10	miR-494	3206	574452	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	miR-494 represses HOXA10 expression and inhibits cell proliferation in oral_cancer .
19084499	0	HOXA10	0,6	p/CAF	18,23	HOXA10	p/CAF	3206	8850	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	HOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells .
11040212	0	HOXA10	35,41	p21	0,3	HOXA10	p21	3206	1026	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells .
15044858	0	HOXA10	0,6	p53	17,20	HOXA10	p53	3206	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	HOXA10 regulates p53 expression and matrigel invasion in human breast_cancer cells .
25630974	0	HOXA11	40,46	MicroRNA-30d	0,12	HOXA11	MicroRNA-30d	3207	407033	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	MicroRNA-30d and microRNA-181a regulate HOXA11 expression in the uterosacral ligaments and are overexpressed in pelvic organ prolapse .
23553814	0	HOXA13	0,6	Aldh1a2	17,24	HOXA13	Aldh1a2	15398(Tax:10090)	19378(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death .
17304517	0	HOXA13	0,6	EphA6	26,31	HOXA13	EphA6	15398(Tax:10090)	13840(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	HOXA13 directly regulates EphA6 and EphA7 expression in the genital_tubercle vascular endothelia .
25779149	0	HOXA13	93,99	HOTTIP	24,30	HOXA13	HOTTIP	3209	100316868	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic_cancer .
25889214	0	HOXA13	93,99	HOTTIP	24,30	HOXA13	HOTTIP	3209	100316868	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic_cancer .
25889214	0	HOXA13	93,99	HOTTIP	24,30	HOXA13	HOTTIP	3209	100316868	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic_cancer .
12112533	0	HOXA13	134,140	HOXA	115,119	HOXA13	HOXA	3209	3197	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The chromosome translocation t -LRB- 7 ; 11 -RRB- -LRB- p15 ; p15 -RRB- in acute_myeloid_leukemia results in fusion of the NUP98 gene with a HOXA cluster gene , HOXA13 , but not HOXA9 .
19723874	0	HOXA4	46,51	beta1_integrin	101,115	HOXA4	beta1 integrin	3201	3688	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Cell motility and spreading are suppressed by HOXA4 in ovarian_cancer cells : possible involvement of beta1_integrin .
16756717	0	HOXA5	0,5	hMLH1	16,21	HOXA5	hMLH1	3202	4292	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	HOXA5 regulates hMLH1 expression in breast_cancer cells .
10875927	0	HOXA5	0,5	progesterone_receptor	34,55	HOXA5	progesterone receptor	3202	5241	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	HOXA5 regulates expression of the progesterone_receptor .
17804711	0	HOXA5	0,5	retinoic_acid_receptor_beta	34,61	HOXA5	retinoic acid receptor beta	3202	5915	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	HOXA5 acts directly downstream of retinoic_acid_receptor_beta and contributes to retinoic_acid-induced apoptosis and growth inhibition .
20389018	0	HOXA9	0,5	BRCA1	16,21	HOXA9	BRCA1	3205	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	HOXA9 regulates BRCA1 expression to modulate human breast_tumor phenotype .
22902925	0	HOXA9	14,19	C/EBPa	72,78	HOXA9	C/EBPa	3205	1050	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
22902925	0	HOXA9	14,19	DACH1	58,63	HOXA9	DACH1	3205	1602	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
22902925	0	HOXA9	14,19	MLL-AF9	115,122	HOXA9	MLL-AF9	3205	4297	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
19620287	0	HOXA9	0,5	Meis1	38,43	HOXA9	Meis1	15405(Tax:10090)	17268(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis .
18474618	0	HOXA9	23,28	MicroRNA-126	0,12	HOXA9	MicroRNA-126	3205	406913	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-126 regulates HOXA9 by binding to the homeobox .
23264595	0	HOXA9	33,38	PBX3	0,4	HOXA9	PBX3	3205	5090	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	PBX3 is an important cofactor of HOXA9 in leukemogenesis .
17327400	0	HOXA9	57,62	Pim1	18,22	HOXA9	Pim1	3205	5292	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	Evidence that the Pim1 kinase gene is a direct target of HOXA9 .
23028966	0	HOXA9	34,39	SHOX	58,62	HOXA9	SHOX	3205	6473	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The homeobox transcription factor HOXA9 is a regulator of SHOX in U2OS cells and chicken micromass cultures .
20444872	0	HOXA9	0,5	miR-155	16,23	HOXA9	miR-155	15405(Tax:10090)	387173(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	HOXA9 regulates miR-155 in hematopoietic cells .
20454457	0	HOXB13	0,6	DNMT3B	20,26	HOXB13	DNMT3B	15408(Tax:10090)	13436(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	HOXB13 , a target of DNMT3B , is methylated at an upstream CpG island , and functions as a tumor suppressor in primary colorectal_tumors .
27018308	0	HOXB13	75,81	ERa	55,58	HOXB13	ERa	10481	2099	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Tumor-associated macrophage-derived CXCL8 could induce ERa suppression via HOXB13 in endometrial_cancer .
24898171	0	HOXB13	0,6	prostate-derived_Ets_factor	21,48	HOXB13	prostate-derived Ets factor	10481	25803	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HOXB13 regulates the prostate-derived_Ets_factor : implications for prostate_cancer cell invasion .
7876223	0	HOXB2	44,49	Transcription_factor_GATA-1	0,27	HOXB2	Transcription factor GATA-1	3212	2623	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription_factor_GATA-1 regulates human HOXB2 gene expression in erythroid cells .
12406897	0	HOXB4	19,24	CD34	112,116	HOXB4	CD34	3214	947	Gene	Gene	expression|compound|START_ENTITY confers|nsubj|expression confers|nmod|advantage advantage|nmod|cells cells|compound|END_ENTITY	High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34 + cells , but impairs lymphomyeloid differentiation .
14529835	0	HOXB4	50,55	CD34	86,90	HOXB4	CD34	3214	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34 + cells promotes myeloid differentiation but not proliferation .
16801129	0	HOXB4	122,127	CD34	73,77	HOXB4	CD34	3214	947	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|compound|END_ENTITY	Stromal cells selectively reduce the growth advantage of human committed CD34 + hematopoietic cells ectopically expressing HOXB4 .
19549386	0	HOXB4	56,61	CD34	81,85	HOXB4	CD34	3214	947	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	-LSB- Analysis on promoter CpG methylation and expression of HOXB4 gene in cord blood CD34 -LRB- + -RRB- cells and peripheral blood mononuclear cells -RSB- .
23028422	0	HOXB4	37,42	CD34	92,96	HOXB4	CD34	3214	947	Gene	Gene	START_ENTITY|nmod|target target|nmod|GATA-2 GATA-2|nmod|cells cells|compound|END_ENTITY	Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34 + hematopoietic cells .
20393131	0	HOXB4	44,49	Hemgn	0,5	HOXB4	Hemgn	15412(Tax:10090)	93966(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells .
21677782	0	HOXB5	0,5	NKX2-1	22,28	HOXB5	NKX2-1	3215	7080	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	HOXB5 cooperates with NKX2-1 in the transcription of human RET .
22844406	0	HOXB7	38,43	PARP-1	20,26	HOXB7	PARP-1	3217	142	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity .
8756643	0	HOXB7	0,5	basic_fibroblast_growth_factor	31,61	HOXB7	basic fibroblast growth factor	3217	2247	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	HOXB7 constitutively activates basic_fibroblast_growth_factor in melanomas .
25183455	0	HOXB7	98,103	miR-337	0,7	HOXB7	miR-337	3217	442905	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-337 regulates the proliferation and invasion in pancreatic_ductal_adenocarcinoma by targeting HOXB7 .
26544896	0	HOXB9	53,58	GalNAc-T14	0,10	HOXB9	GalNAc-T14	3219	79623	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|nsubj|END_ENTITY	GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung_adenocarcinoma .
22907429	0	HOXC6	39,44	MDR-1	30,35	HOXC6	MDR-1	3223	5243	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of MDR-1 by HOXC6 in multidrug-resistant cells .
21047772	0	HOXC8	0,5	androgen_receptor	15,32	HOXC8	androgen receptor	3224	367	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	HOXC8 inhibits androgen_receptor signaling in human prostate_cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes .
21419107	0	HOXD10	87,93	MMP-14	56,62	HOXD10	MMP-14	3236	4323	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10 .
21419107	0	HOXD10	87,93	MicroRNA-10b	0,12	HOXD10	MicroRNA-10b	3236	406903	Gene	Gene	expression|nmod|START_ENTITY modulating|dobj|expression induces|advcl|modulating induces|nsubj|END_ENTITY	MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10 .
24376640	0	HOXD10	96,102	MicroRNA-10b	0,12	HOXD10	MicroRNA-10b	3236	406903	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc_degeneration .
7742539	0	HOXD3	29,34	HOX4A	22,27	HOXD3	HOX4A	3232	3232	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Overexpression of the HOX4A -LRB- HOXD3 -RRB- homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties .
12836255	0	HOXD3	0,5	JAGGED1	30,37	HOXD3	JAGGED1	3232	182	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	HOXD3 regulates expression of JAGGED1 , a ligand for Notch receptors .
26901066	0	HP	32,34	haptoglobin	36,47	HP	haptoglobin	3240	3240	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Recurring exon deletions in the HP -LRB- haptoglobin -RRB- gene contribute to lower blood cholesterol levels .
24767863	0	HP0986	28,34	TNFR1	63,68	HP0986	TNFR1	899519(Tax:85962)	21937(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Helicobacter_pylori protein HP0986 -LRB- TieA -RRB- interacts with mouse TNFR1 and triggers proinflammatory and proapoptotic signaling pathways in cultured macrophage cells -LRB- RAW 264.7 -RRB- .
12376620	0	HP1	46,49	HP2	27,30	HP1	HP2	34119(Tax:7227)	36621(Tax:7227)	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Heterochromatin_protein_2 -LRB- HP2 -RRB- , a partner of HP1 in Drosophila heterochromatin .
19352502	0	HP1	27,30	Heterochromatin_protein_1	0,25	HP1	Heterochromatin protein 1	23468	23468	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Heterochromatin_protein_1 -LRB- HP1 -RRB- proteins do not drive pericentromeric cohesin enrichment in human cells .
10516442	0	HP1	36,39	M31	0,3	HP1	M31	31834(Tax:7227)	110831(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	M31 , a murine homolog of Drosophila HP1 , is concentrated in the XY body during spermatogenesis .
17698499	0	HP1	21,24	MeCP2	0,5	HP1	MeCP2	23468	4204	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation .
11959914	0	HP1	32,35	TAFII130	47,55	HP1	TAFII130	23468	6874	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Isoform-specific interaction of HP1 with human TAFII130 .
21163256	0	HP1	23,26	TIF1b	0,5	HP1	TIF1b	23468	10155	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	TIF1b association with HP1 is essential for post-gastrulation development , but not for Sertoli cell functions during spermatogenesis .
18287239	0	HP1	76,79	TRIM28	91,97	HP1	TRIM28	12419(Tax:10090)	21849(Tax:10090)	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Primer binding site-dependent restriction_of_murine_leukemia virus requires HP1 binding by TRIM28 .
21267468	0	HP1	0,3	activity-dependent_neuroprotective_protein	13,55	HP1	activity-dependent neuroprotective protein	23468	23394	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|END_ENTITY	HP1 recruits activity-dependent_neuroprotective_protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats .
15592864	0	HP1	44,47	heterochromatin_protein_1	17,42	HP1	heterochromatin protein 1	34119(Tax:7227)	34119(Tax:7227)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Mutations in the heterochromatin_protein_1 -LRB- HP1 -RRB- hinge domain affect HP1 protein interactions and chromosomal distribution .
23645696	0	HP1a	178,182	KAP1	141,145	HP1a	KAP1	23468	10155	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Phosphorylation of KRAB-associated_protein_1 -LRB- KAP1 -RRB- at Tyr-449 , Tyr-458 , and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin_protein_1a -LRB- HP1a -RRB- with heterochromatin .
19566924	0	HP1alpha	27,35	YY1	12,15	HP1alpha	YY1	23468	7528	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	The role of YY1 in reduced HP1alpha gene expression in invasive human breast_cancer cells .
15947784	0	HP1beta	19,26	EMSY	11,15	HP1beta	EMSY	10951	56946	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of EMSY to HP1beta : implications for recruitment of HP1beta and BS69 .
12376620	0	HP2	27,30	HP1	46,49	HP2	HP1	36621(Tax:7227)	34119(Tax:7227)	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Heterochromatin_protein_2 -LRB- HP2 -RRB- , a partner of HP1 in Drosophila heterochromatin .
11514372	0	HPA-2	30,35	glycoprotein_Ibalpha	9,29	HPA-2	glycoprotein Ibalpha	60495	2811	Gene	Gene	B|compound|START_ENTITY B|compound|END_ENTITY	Platelet glycoprotein_Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial_infarction and sudden_cardiac_death .
22880801	0	HPA-3	26,31	glycoprotein_IIb	9,25	HPA-3	glycoprotein IIb	3674	3674	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Platelet glycoprotein_IIb HPA-3 a/b polymorphism is associated with native arteriovenous fistula thrombosis in chronic hemodialysis patients .
9070225	0	HPC-1	26,31	syntaxin_1A	14,25	HPC-1	syntaxin 1A	20907(Tax:10090)	20907(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	Overexpressed syntaxin_1A / HPC-1 inhibits insulin secretion via a regulated pathway , but does not influence glucose metabolism and intracellular Ca2 + in insulinoma cell line beta_TC3 cells .
7851880	0	HPD	69,72	4-hydroxyphenylpyruvic_acid_dioxygenase	23,62	HPD	4-hydroxyphenylpyruvic acid dioxygenase	3242	3242	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure of the human 4-hydroxyphenylpyruvic_acid_dioxygenase gene -LRB- HPD -RRB- .
1427907	0	HPF9	51,55	ZNF117	43,49	HPF9	ZNF117	51351	51351	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the human KRAB finger gene ZNF117 -LRB- HPF9 -RRB- to chromosome 7q11 .2 .
7686501	0	HPFH	37,41	gamma-globin	42,54	HPFH	gamma-globin	7954	3047	Gene	Gene	promoters|compound|START_ENTITY promoters|amod|END_ENTITY	Comparative studies of nondeletional HPFH gamma-globin gene promoters .
20957749	0	HPK1	0,4	ADAP	19,23	HPK1	ADAP	11184	2533	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion .
20824186	0	HPK1	0,4	SKAP-HOM	21,29	HPK1	SKAP-HOM	26411(Tax:10090)	54353;51944	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion .
22421156	0	HPK1	48,52	hematopoietic_progenitor_kinase_1	13,46	HPK1	hematopoietic progenitor kinase 1	11184	11184	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Dual role of hematopoietic_progenitor_kinase_1 -LRB- HPK1 -RRB- as a positive regulator of 1a,25-dihydroxyvitamin _ D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin_D resistance .
1125152	0	HPL	50,53	placental_lactogen	30,48	HPL	placental lactogen	3956	1443	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	The prognostic value of human placental_lactogen -LRB- HPL -RRB- levels in threatened abortion .
187001	0	HPL	32,35	placental_lactogen	12,30	HPL	placental lactogen	3956	1443	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum human placental_lactogen -LRB- HPL -RRB- levels in patients with intact hydatidiform mole .
3902860	0	HPL	144,147	placental_lactogen	96,114	HPL	placental lactogen	3956	1443	Gene	Gene	action|compound|START_ENTITY mediation|nmod|action END_ENTITY|dep|mediation	Incorporation of -LSB- 3H -RSB- thymidine by isolated fetal myoblasts and fibroblasts in response to human placental_lactogen -LRB- HPL -RRB- : possible mediation of HPL action by release of immunoreactive SM-C .
4339409	0	HPL	52,55	placental_lactogen	32,50	HPL	placental lactogen	3956	1443	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	-LSB- Biological properties of human placental_lactogen -LRB- HPL ; human chorionic somatomammotropin -RRB- -RSB- .
4985807	2	HPL	92,95	placental_lactogen	72,90	HPL	placental lactogen	3956	1443	Gene	Gene	Biosynthesis|appos|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of human placental_lactogen -LRB- HPL -RRB- -RSB- .
7008399	0	HPL	27,30	placental_lactogen	7,25	HPL	placental lactogen	3956	1443	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Human placental_lactogen -LRB- HPL -RRB- levels in the maternal serum following long-term intake of xantinol_nicotinate -LRB- Complamin_Retard -RRB- -LRB- author 's transl -RRB- -RSB- .
7008458	0	HPL	40,43	placental_lactogen	20,38	HPL	placental lactogen	3956	1443	Gene	Gene	Behaviour|appos|START_ENTITY Behaviour|nmod|END_ENTITY	-LSB- Behaviour of human placental_lactogen -LRB- HPL -RRB- following continuous glucose infusion in late pregnancy -LRB- author 's transl -RRB- -RSB- .
7304144	0	HPL	46,49	placental_lactogen	26,44	HPL	placental lactogen	3956	1443	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of human placental_lactogen -LRB- HPL -RRB- in an unselected obstetrical population .
11779847	0	HPR1	56,60	heparanase-1	42,54	HPR1	heparanase-1	10855	10855	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Cloning and characterization of the human heparanase-1 -LRB- HPR1 -RRB- gene promoter : role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity .
11821985	0	HPRT	132,136	GAPDH	69,74	HPRT	GAPDH	100126071(Tax:9986)	100009074(Tax:9986)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Differential expression of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- , beta actin and hypoxanthine_phosphoribosyltransferase _ -LRB- HPRT -RRB- _ in_postnatal_rabbit_sclera .
8878108	0	HPRT	48,52	Hypoxanthine-guanine_phosphoribosyltransferase	0,46	HPRT	Hypoxanthine-guanine phosphoribosyltransferase	15452(Tax:10090)	15452(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer .
11821985	0	HPRT	132,136	glyceraldehyde-3-phosphate_dehydrogenase	27,67	HPRT	glyceraldehyde-3-phosphate dehydrogenase	100126071(Tax:9986)	100009074(Tax:9986)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- , beta actin and hypoxanthine_phosphoribosyltransferase _ -LRB- HPRT -RRB- _ in_postnatal_rabbit_sclera .
1678246	0	HPRT	78,82	hypoxanthine-guanine_phosphoribosyltransferase	30,76	HPRT	hypoxanthine-guanine phosphoribosyltransferase	3251	3251	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Fine structure mapping of the hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- gene region of the human X chromosome -LRB- Xq26 -RRB- .
1970211	0	HPRT	101,105	hypoxanthine-guanine_phosphoribosyltransferase	53,99	HPRT	hypoxanthine-guanine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Bam HI restriction fragment length polymorphisms for hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- gene of carriers and controls of HPRT_deficiency in Japan .
2018042	0	HPRT	113,117	hypoxanthine-guanine_phosphoribosyltransferase	65,111	HPRT	hypoxanthine-guanine phosphoribosyltransferase	3251	3251	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Identification of 17 independent mutations responsible for human hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- deficiency .
8314557	0	HPRT	147,151	hypoxanthine-guanine_phosphoribosyltransferase	99,145	HPRT	hypoxanthine-guanine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of two new nucleotide mutations -LRB- HPRTUtrecht and HPRTMadrid -RRB- in exon 3 of the human hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- gene .
9003484	0	HPRT	99,103	hypoxanthine_phosphoribosyltransferase	59,97	HPRT	hypoxanthine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An asymptomatic germline missense base substitution in the hypoxanthine_phosphoribosyltransferase -LRB- HPRT -RRB- gene that reduces the amount of enzyme in humans .
9799086	0	HPRT	186,190	hypoxanthine_phosphoribosyltransferase	146,184	HPRT	hypoxanthine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of two deletion events involving Alu-sequences , one novel base substitution and two tentative hotspot mutations in the hypoxanthine_phosphoribosyltransferase -LRB- HPRT -RRB- gene in five patients with Lesch-Nyhan_syndrome .
11668636	0	HPRT1	87,92	hypoxanthine_phosphoribosyltransferase	47,85	HPRT1	hypoxanthine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A recurrent large Alu-mediated deletion in the hypoxanthine_phosphoribosyltransferase -LRB- HPRT1 -RRB- gene associated with Lesch-Nyhan_syndrome .
24168225	0	HPS4	53,57	Hermansky-Pudlak_syndrome_type_4	19,51	HPS4	Hermansky-Pudlak syndrome type 4	89781	89781	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the Hermansky-Pudlak_syndrome_type_4 -LRB- HPS4 -RRB- gene variants with cognitive function in patients with schizophrenia and healthy subjects .
23250771	0	HPS5	53,57	Hermansky-Pudluck_syndrome-5	23,51	HPS5	Hermansky-Pudluck syndrome-5	11234	11234	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A homolog of the human Hermansky-Pudluck_syndrome-5 -LRB- HPS5 -RRB- gene is responsible for the oa larval translucent mutants in the silkworm , Bombyx_mori .
22715311	0	HPSE	39,43	Heparanase	27,37	HPSE	Heparanase	10855	10855	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A Phylogenetic analysis of Heparanase -LRB- HPSE -RRB- gene .
19758440	6	HR	1692,1694	HER2	1696,1700	HR	HER2	3164	2064	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Biology-based tumor type -LRB- P = 0.046 for HR + / HER2 + vs. HR + / HER2 - -RRB- , Ki67 labeling index -LRB- P = 0.028 -RRB- , and treatment arm -LRB- P = 0.036 -RRB- were independent predictors of pCR in a multivariate model .
26227964	0	HR	86,88	HER2	90,94	HR	HER2	3164	2064	Gene	Gene	therapy|nmod|START_ENTITY axis|nmod|therapy axis|parataxis|breast_cancers breast_cancers|nsubj|_ _|compound|END_ENTITY	Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR - / HER2 + _ breast_cancers .
15233798	0	HR3	65,68	E75	70,73	HR3	E75	692562(Tax:7091)	692595(Tax:7091)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR , HR3 , E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera .
15233798	0	HR3	65,68	EcR	60,63	HR3	EcR	692562(Tax:7091)	692756(Tax:7091)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Effects of juvenile hormone on 20-hydroxyecdysone-inducible EcR , HR3 , E75 gene expression in imaginal wing cells of Plodia interpunctella lepidoptera .
20012784	0	HRAS	29,33	BRAF	11,15	HRAS	BRAF	3265	673	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
22294102	0	HRAS	23,27	BRAF	73,77	HRAS	BRAF	3265	673	Gene	Gene	gene|compound|START_ENTITY gene|nmod|mutations mutations|nmod|genes genes|compound|END_ENTITY	Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral_squamous_cell_carcinoma in a Greek population .
26165597	0	HRAS	125,129	BRAF	32,36	HRAS	BRAF	3265	673	Gene	Gene	Exhibits|nmod|START_ENTITY Exhibits|nsubj|Domain Domain|nmod|Kinase Kinase|compound|END_ENTITY	The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS .
1631055	0	HRAS	8,12	GLUT2	27,32	HRAS	GLUT2	15461(Tax:10090)	20526(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	-LSB- Val12 -RSB- HRAS downregulates GLUT2 in beta cells of transgenic_mice without affecting glucose homeostasis .
20012784	0	HRAS	29,33	KRAS	23,27	HRAS	KRAS	3265	3845	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
22820081	0	HRAS	27,31	KRAS	33,37	HRAS	KRAS	3265	3845	Gene	Gene	NRAS|compound|START_ENTITY NRAS|dep|END_ENTITY	The mutational spectrum of HRAS , KRAS , NRAS and FGFR3 genes in bladder_cancer .
23666916	0	HRAS	102,106	KRAS	90,94	HRAS	KRAS	3265	3845	Gene	Gene	BRAF|compound|START_ENTITY END_ENTITY|dep|BRAF	FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type -LRB- KRAS , NRAS , HRAS , BRAF -RRB- metastatic colorectal_cancer patients : a phase II trial by the Gruppo Oncologico Nord Ovest -LRB- GONO -RRB- .
20012784	0	HRAS	29,33	NRAS	17,21	HRAS	NRAS	3265	4893	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
23666916	0	HRAS	102,106	NRAS	96,100	HRAS	NRAS	3265	4893	Gene	Gene	BRAF|compound|START_ENTITY KRAS|dep|BRAF KRAS|dep|END_ENTITY	FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type -LRB- KRAS , NRAS , HRAS , BRAF -RRB- metastatic colorectal_cancer patients : a phase II trial by the Gruppo Oncologico Nord Ovest -LRB- GONO -RRB- .
15082771	0	HRC	0,3	MEF2	42,46	HRC	MEF2	15464(Tax:10090)	17260(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	HRC is a direct transcriptional target of MEF2 during cardiac , skeletal , and arterial smooth muscle development in vivo .
1702128	0	HRF	50,53	histamine-releasing_factor	22,48	HRF	histamine-releasing factor	7178	7178	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Altered production of histamine-releasing_factor -LRB- HRF -RRB- activity and responsiveness to HRF after immunotherapy in children with asthma .
1382994	0	HRF20	81,86	CD59	88,92	HRF20	CD59	966	966	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Paroxysmal_nocturnal_hemoglobinuria due to hereditary nucleotide deletion in the HRF20 -LRB- CD59 -RRB- gene .
9159406	0	HRF20	21,26	CD59	28,32	HRF20	CD59	966	966	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Unique expression of HRF20 -LRB- CD59 -RRB- in human nervous tissue .
7794748	0	HRF20	64,69	homologous_restriction_factor_20KD	28,62	HRF20	homologous restriction factor 20KD	966	966	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Flow cytometric analysis of homologous_restriction_factor_20KD -LRB- HRF20 -RRB- expression on progeny cells during differentiation from haemopoietic progenitors in paroxysmal_nocturnal_haemoglobinuria .
19712047	0	HRG	43,46	histidine-rich_glycoprotein	14,41	HRG	histidine-rich glycoprotein	3273	3273	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of histidine-rich_glycoprotein -LRB- HRG -RRB- function via plasmin-mediated proteolytic cleavage .
6818678	0	HRG	57,60	histidine-rich_glycoprotein	28,55	HRG	histidine-rich glycoprotein	3273	3273	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Individual levels of plasma histidine-rich_glycoprotein -LRB- HRG -RRB- during the normal menstrual cycle and in women on oral contraceptives low in oestrogen .
7667832	0	HRG	53,56	histidine-rich_glycoprotein	24,51	HRG	histidine-rich glycoprotein	3273	3273	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Estrogens reduce plasma histidine-rich_glycoprotein -LRB- HRG -RRB- levels in a dose-dependent way .
12527357	0	HRG4	31,35	ARL2	60,64	HRG4	ARL2	9094	402	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Photoreceptor synaptic protein HRG4 -LRB- UNC119 -RRB- interacts with ARL2 via a putative conserved domain .
17174953	0	HRG4	34,38	UNC119	40,46	HRG4	UNC119	22248(Tax:10090)	22248(Tax:10090)	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Targeted inactivation of synaptic HRG4 -LRB- UNC119 -RRB- causes dysfunction in the distal photoreceptor and slow retinal_degeneration , revealing a new function .
11956964	0	HRH3	51,55	histamine_H3_receptor	23,44	HRH3	histamine H3 receptor	11255	11255	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure of the human histamine_H3_receptor gene -LRB- HRH3 -RRB- and identification of naturally occurring variations .
12767237	0	HRI	116,119	eIF2alpha	87,96	HRI	eIF2alpha	27102	83939	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI .
7755634	0	HRS	95,98	histidyl-tRNA_synthetase	69,93	HRS	histidyl-tRNA synthetase	3035	3035	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA_synthetase -LRB- HRS -RRB- gene encodes an mRNA that predicts a polypeptide homologous to HRS .
10593953	0	HRad17	0,6	NHP2L1	24,30	HRad17	NHP2L1	5884	4809	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation .
10232579	0	HRad17	0,6	rad17	75,80	HRad17	rad17	5884	5884	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	HRad17 , a human homologue of the Schizosaccharomyces_pombe checkpoint gene rad17 , is overexpressed in colon_carcinoma .
22679023	0	HS1	29,32	Arp2/3	48,54	HS1	Arp2/3	10971	10097;10096	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis .
8720131	0	HS1	19,22	Fc_gamma_RIIIA	103,117	HS1	Fc gamma RIIIA	15163(Tax:10090)	2214	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of HS1 , GAP-associated p190 and a novel GAP-associated p60 protein by cross-linking of Fc_gamma_RIIIA .
10713104	0	HS1	0,3	Lyn	19,22	HS1	Lyn	3059	4067	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells .
22768161	0	HS1	0,3	Lyn	7,10	HS1	Lyn	3059	4067	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	HS1 , a Lyn kinase substrate , is abnormally expressed in B-chronic_lymphocytic_leukemia and correlates with response to fludarabine-based regimen .
18586828	0	HS2	66,69	GATA-1	38,44	HS2	GATA-1	6710	2623	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of transcriptional activator GATA-1 at human beta-globin HS2 .
25547674	0	HSC	117,120	Gpr56	108,113	HSC	Gpr56	2523	9289	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation .
22572381	0	HSC-3	87,92	Bim	62,65	HSC-3	Bim	150353	10018	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	BHLH transcription factor DEC2 regulates pro-apoptotic factor Bim in human oral_cancer HSC-3 cells .
22171070	0	HSC20	0,5	frataxin	21,29	HSC20	frataxin	150274	2395	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis .
9675148	0	HSC70	27,32	HSP105	15,21	HSC70	HSP105	15481(Tax:10090)	15505(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells .
16239242	0	HSC70	49,54	HSP70	13,18	HSC70	HSP70	3312	3308	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cells .
7726639	0	HSC70	92,97	HSP70	50,55	HSC70	HSP70	3312	3308	Gene	Gene	protein|appos|START_ENTITY cognate|dobj|protein cognate|nsubj|expression expression|nmod|heat_shock_protein_70 heat_shock_protein_70|appos|END_ENTITY	Differential expression of heat_shock_protein_70 -LRB- HSP70 -RRB- and heat_shock cognate protein 70 -LRB- HSC70 -RRB- in human epidermis .
18379898	0	HSC70	45,50	KLF4	54,58	HSC70	KLF4	15481(Tax:10090)	16600(Tax:10090)	Gene	Gene	expressed|dobj|START_ENTITY expressed|nmod|END_ENTITY	Upregulation of the constitutively expressed HSC70 by KLF4 .
26694452	0	HSCARG	101,107	Glucose-6-Phosphate_Dehydrogenase	0,33	HSCARG	Glucose-6-Phosphate Dehydrogenase	57407	2539	Gene	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	Glucose-6-Phosphate_Dehydrogenase Enhances Antiviral Response through Downregulation of NADPH Sensor HSCARG and Upregulation of NF-kB Signaling .
19433587	0	HSCARG	0,6	NF-kappaB	17,26	HSCARG	NF-kappaB	57407	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	HSCARG regulates NF-kappaB activation by promoting the ubiquitination of RelA or COMMD1 .
11916625	0	HSD11B2	32,39	11beta-hydroxysteroid_dehydrogenase_type_2	61,103	HSD11B2	11beta-hydroxysteroid dehydrogenase type 2	3291	3291	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association studies between the HSD11B2 gene -LRB- encoding human 11beta-hydroxysteroid_dehydrogenase_type_2 -RRB- , type_1_diabetes_mellitus and diabetic_nephropathy .
9709959	0	HSD17B3	112,119	17beta-hydroxysteroid_dehydrogenase	68,103	HSD17B3	17beta-hydroxysteroid dehydrogenase	3293	345275	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deleterious missense mutations and silent polymorphism in the human 17beta-hydroxysteroid_dehydrogenase 3 gene -LRB- HSD17B3 -RRB- .
26465200	0	HSD3B2	87,93	Nur77	74,79	HSD3B2	Nur77	3284	79240(Tax:10116)	Gene	Gene	Promoter|compound|START_ENTITY END_ENTITY|nmod|Promoter	A Dietary Medium-Chain Fatty_Acid , Decanoic_Acid , Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic_Abnormalities in a Rat Model of Polycystic_Ovary_Syndrome .
12153137	0	HSDL1	56,61	hydroxysteroid_dehydrogenase_like_1	14,49	HSDL1	hydroxysteroid dehydrogenase like 1	83693	83693	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel human hydroxysteroid_dehydrogenase_like_1 gene -LRB- HSDL1 -RRB- is highly expressed in reproductive tissues .
19026618	0	HSDL1	57,62	hydroxysteroid_dehydrogenase_like_1	20,55	HSDL1	hydroxysteroid dehydrogenase like 1	494064(Tax:7955)	494064(Tax:7955)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Human and zebrafish hydroxysteroid_dehydrogenase_like_1 -LRB- HSDL1 -RRB- proteins are inactive enzymes but conserved among species .
11136617	0	HSF	89,92	heat-shock_transcription_factor	56,87	HSF	heat-shock transcription factor	37068(Tax:7227)	37068(Tax:7227)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Laboratory selection at different temperatures modifies heat-shock_transcription_factor -LRB- HSF -RRB- activation in Drosophila_melanogaster .
8761470	0	HSF	52,55	heat-shock_transcription_factor	19,50	HSF	heat-shock transcription factor	3569	3569	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Dual regulation of heat-shock_transcription_factor -LRB- HSF -RRB- activation and DNA-binding activity by H2O2 : role of thioredoxin .
1628823	0	HSF	50,53	hsp70	29,34	HSF	hsp70	3569	3308	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The human heat shock protein hsp70 interacts with HSF , the transcription factor that regulates heat shock gene expression .
24469056	0	HSF-1	33,38	Akt	0,3	HSF-1	Akt	3297	207	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt phosphorylates and activates HSF-1 independent of heat_shock , leading to Slug overexpression and epithelial-mesenchymal transition -LRB- EMT -RRB- of HER2-overexpressing breast_cancer cells .
21408062	0	HSF-1	61,66	DAF-16	21,27	HSF-1	DAF-16	173078(Tax:6239)	172981(Tax:6239)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Co-regulation of the DAF-16 target gene , cyp-35B1 / dod-13 , by HSF-1 in C. _ elegans dauer larvae and daf-2 insulin pathway mutants .
12621024	0	HSF-1	0,5	Ral-binding_protein_1	21,42	HSF-1	Ral-binding protein 1	15499(Tax:10090)	19765(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HSF-1 interacts with Ral-binding_protein_1 in a stress-responsive , multiprotein complex with HSP90 in vivo .
24786827	0	HSF1	77,81	ANG_II	0,6	HSF1	ANG II	3297	183	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	ANG_II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation .
23959823	0	HSF1	0,4	FUT4	22,26	HSF1	FUT4	3297	2526	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	HSF1 and Sp1 regulate FUT4 gene expression and cell proliferation in breast_cancer cells .
21455770	0	HSF1	0,4	G-CSF	29,34	HSF1	G-CSF	15499(Tax:10090)	12985(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	HSF1 regulates expression of G-CSF through the binding element for NF-IL6 / CCAAT enhancer binding protein beta .
24361604	0	HSF1	32,36	HYPK	100,104	HSF1	HYPK	3297	25764	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Heat shock transcription factor HSF1 regulates the expression of the Huntingtin-interacting protein HYPK .
24127737	0	HSF1	74,78	JUN	19,22	HSF1	JUN	3297	3725	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The proto-oncogene JUN is a target of the heat shock transcription factor HSF1 .
25537516	0	HSF1	17,21	MicroRNA-135b	0,13	HSF1	MicroRNA-135b	3297	442891	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	MicroRNA-135b , a HSF1 target , promotes tumor invasion and metastasis by regulating RECK and EVI5_in_hepatocellular_carcinoma .
26890141	0	HSF1	118,122	PGC1a	32,37	HSF1	PGC1a	15499(Tax:10090)	19017(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	The transcriptional coactivator PGC1a protects against hyperthermic stress via cooperation with the heat_shock factor HSF1 .
23587726	0	HSF1	109,113	RGS2	68,72	HSF1	RGS2	3297	5997	Gene	Gene	transcription|nmod|START_ENTITY transcription|appos|END_ENTITY	Stress-induced transcription of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- by heat_shock transcription factor HSF1 .
16303760	0	HSF1	0,4	XAF1	20,24	HSF1	XAF1	3297	54739	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	HSF1 down-regulates XAF1 through transcriptional regulation .
24954509	0	HSF1	0,4	b-catenin	19,28	HSF1	b-catenin	3297	1499	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	HSF1 regulation of b-catenin in mammary cancer cells through control of HuR/elavL1 expression .
22042860	0	HSF1	44,48	heat-shock_factor_1	23,42	HSF1	heat-shock factor 1	3297	3297	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	High levels of nuclear heat-shock_factor_1 -LRB- HSF1 -RRB- are associated with poor prognosis in breast_cancer .
10224227	0	HSF1	54,58	hsp70	80,85	HSF1	hsp70	3297	3308	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70 .
23587726	0	HSF1	109,113	regulator_of_G_protein_signaling_2	32,66	HSF1	regulator of G protein signaling 2	3297	5997	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Stress-induced transcription of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- by heat_shock transcription factor HSF1 .
17915561	0	HSF2	0,4	Hsp90	18,23	HSF2	Hsp90	3298	3320	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	HSF2 binds to the Hsp90 , Hsp27 , and c-Fos promoters constitutively and modulates their expression .
18211895	0	HSF2	22,26	MEL-18	0,6	HSF2	MEL-18	3298	7703	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation .
18211895	0	HSF2	59,63	MEL-18	0,6	HSF2	MEL-18	3298	7703	Gene	Gene	sumoylation|compound|START_ENTITY inhibit|dobj|sumoylation interacts|xcomp|inhibit interacts|nsubj|END_ENTITY	MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation .
18570919	0	HSF2	60,64	PRC1	0,4	HSF2	PRC1	15500(Tax:10090)	233406(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	PRC1 associates with the hsp70i promoter and interacts with HSF2 during mitosis .
26319152	0	HSF4	21,25	BCAS2	0,5	HSF4	BCAS2	3299	10286	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination .
23507146	0	HSF4	0,4	DLAD	15,19	HSF4	DLAD	26386(Tax:10090)	56629(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	HSF4 regulates DLAD expression and promotes lens de-nucleation .
22587838	0	HSF4	0,4	Rad51	60,65	HSF4	Rad51	503739(Tax:7955)	406487(Tax:7955)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	HSF4 is involved in DNA damage repair through regulation of Rad51 .
10832769	0	HSL	92,95	hormone-sensitive_lipase	66,90	HSL	hormone-sensitive lipase	25330(Tax:10116)	25330(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Free fatty_acids are involved in the inverse relationship between hormone-sensitive_lipase -LRB- HSL -RRB- activity and expression in adipose tissue after high-fat feeding or beta3-adrenergic stimulation .
20691154	0	HSL	47,50	hormone-sensitive_lipase	21,45	HSL	hormone-sensitive lipase	25330(Tax:10116)	25330(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Testosterone affects hormone-sensitive_lipase -LRB- HSL -RRB- activity and lipid metabolism in the left ventricle .
24443229	0	HSL	54,57	hormone-sensitive_lipase	23,47	HSL	hormone-sensitive lipase	100169699(Tax:9940)	100169699(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in the ovine hormone-sensitive_lipase gene -LRB- HSL -RRB- and its association with growth and carcass traits in New Zealand Suffolk sheep .
26435886	0	HSP-1	128,133	UNC-23	15,21	HSP-1	UNC-23	178507(Tax:6239)	179272(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The C. _ elegans UNC-23 protein , a member of the BCL-2-associated athanogene -LRB- BAG -RRB- family of chaperone regulators , interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity .
10638664	0	HSP-70	66,72	heat_shock_protein_70	43,64	HSP-70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cecal ligation and double puncture impairs heat_shock_protein_70 -LRB- HSP-70 -RRB- expression in the lungs of rats .
24388965	0	HSP-90	45,51	nsP4	25,29	HSP-90	nsP4	3320	400668	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Chikungunya_virus nsP3 _ nsP4 interacts with HSP-90 to promote virus replication : HSP-90 inhibitors reduce CHIKV_infection and inflammation in vivo .
24388965	0	HSP-90	82,88	nsP4	25,29	HSP-90	nsP4	3320	400668	Gene	Gene	inhibitors|compound|START_ENTITY reduce|nsubj|inhibitors interacts|ccomp|reduce interacts|nsubj|END_ENTITY	Chikungunya_virus nsP3 _ nsP4 interacts with HSP-90 to promote virus replication : HSP-90 inhibitors reduce CHIKV_infection and inflammation in vivo .
18083346	0	HSP105	0,6	GRP78	22,27	HSP105	GRP78	10808	3309	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation .
9675148	0	HSP105	15,21	HSC70	27,32	HSP105	HSC70	15505(Tax:10090)	15481(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of HSP105 with HSC70 in high molecular mass complexes in mouse FM3A cells .
25645927	0	HSP105	0,6	PP2A	16,20	HSP105	PP2A	10808	5524	Gene	Gene	Recruits|compound|START_ENTITY END_ENTITY|nsubj|Recruits	HSP105 Recruits PP2A to Dephosphorylate b-Catenin .
16225851	0	HSP20	35,40	HSP22	16,21	HSP20	HSP22	126393	26353	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of HSP22 -LRB- HSPB8 -RRB- with HSP20 , alphaB-crystallin , and HSPB3 .
22139844	0	HSP20	41,46	heat_shock_protein_20	18,39	HSP20	heat shock protein 20	126393	126393	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role for heat_shock_protein_20 -LRB- HSP20 -RRB- in migration of malarial sporozoites .
23922206	0	HSP21	37,42	pTAC5	83,88	HSP21	pTAC5	828881(Tax:3702)	827001(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Chloroplast small heat_shock protein HSP21 interacts with plastid nucleoid protein pTAC5 and is essential for chloroplast development in Arabidopsis under heat stress .
16225851	0	HSP22	16,21	HSP20	35,40	HSP22	HSP20	26353	126393	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of HSP22 -LRB- HSPB8 -RRB- with HSP20 , alphaB-crystallin , and HSPB3 .
8596706	0	HSP25	20,25	HSP60	27,32	HSP25	HSP60	24471(Tax:10116)	63868(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Heat_shock proteins HSP25 , HSP60 , HSP72 , HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney .
8596706	0	HSP25	20,25	HSP72	34,39	HSP25	HSP72	24471(Tax:10116)	24472(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Heat_shock proteins HSP25 , HSP60 , HSP72 , HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney .
15848222	0	HSP27	31,36	Akt	0,3	HSP27	Akt	24471(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells : function at a point downstream from p38 MAP kinase .
15896702	0	HSP27	96,101	Akt	54,57	HSP27	Akt	24471(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY signal|nmod|phosphorylation signal|nsubj|involvement involvement|nmod|END_ENTITY	Possible involvement of phosphatidylinositol_3-kinase / Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells .
16514645	0	HSP27	85,90	Akt	30,33	HSP27	Akt	15507(Tax:10090)	11651(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY role|nmod|induction plays|dobj|role plays|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt plays a role in sphingosine_1-phosphate-stimulated HSP27 induction in osteoblasts .
17342744	0	HSP27	0,5	CD10	30,34	HSP27	CD10	3315	4311	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	HSP27 and HSP70 interact with CD10 in C4-2 prostate_cancer cells .
20410505	0	HSP27	0,5	GATA-1	15,21	HSP27	GATA-1	3315	2623	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|level level|compound|END_ENTITY	HSP27 controls GATA-1 protein level during erythroid cell differentiation .
15810071	0	HSP27	35,40	GRP94	70,75	HSP27	GRP94	3315	7184	Gene	Gene	HSP60|compound|START_ENTITY HSP60|dep|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
12942564	0	HSP27	20,25	HSP70	34,39	HSP27	HSP70	3315	3308	Gene	Gene	HSP60|nummod|START_ENTITY HSP60|nummod|END_ENTITY	Heat_shock proteins HSP27 , HSP60 , HSP70 , and HSP90 : expression in bladder_carcinoma .
15810071	0	HSP27	35,40	HSP70	49,54	HSP27	HSP70	3315	3308	Gene	Gene	HSP60|compound|START_ENTITY HSP60|dep|HSP90 HSP90|compound|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
19350847	0	HSP27	9,14	HSP70	16,21	HSP27	HSP70	3315	3308	Gene	Gene	Elevated|nummod|START_ENTITY Elevated|nummod|END_ENTITY	Elevated HSP27 , HSP70 and HSP90_alpha in chronic_obstructive_pulmonary_disease : markers for immune activation and tissue destruction .
9389084	0	HSP27	48,53	HSP70	41,46	HSP27	HSP70	3315	3308	Gene	Gene	START_ENTITY|nsubj|Study Study|appos|END_ENTITY	Study of heat_shock protein HSP90_alpha , HSP70 , HSP27 mRNA expression in human acute_leukemia cells .
15810071	0	HSP27	35,40	HSP90	56,61	HSP27	HSP90	3315	3320	Gene	Gene	HSP60|compound|START_ENTITY HSP60|dep|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
25202074	0	HSP27	0,5	HSP90	63,68	HSP27	HSP90	3315	3320	Gene	Gene	knockdown|compound|START_ENTITY produces|nsubj|knockdown produces|nmod|inhibitors inhibitors|compound|END_ENTITY	HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma_multiforme .
9389084	0	HSP27	48,53	HSP90_alpha	28,39	HSP27	HSP90 alpha	3315	3320	Gene	Gene	START_ENTITY|nsubj|Study Study|nmod|END_ENTITY	Study of heat_shock protein HSP90_alpha , HSP70 , HSP27 mRNA expression in human acute_leukemia cells .
26504030	0	HSP27	97,102	Heat_Shock_Factor_1	49,68	HSP27	Heat Shock Factor 1	3315	3297	Gene	Gene	Factor|nmod|START_ENTITY END_ENTITY|appos|Factor	Active Hexose-correlated Compound Down-regulates Heat_Shock_Factor_1 , a Transcription Factor for HSP27 , in Gemcitabine-resistant Human Pancreatic_Cancer Cells .
16086037	0	HSP27	117,122	MAPKAPK-2	107,116	HSP27	MAPKAPK-2	24471(Tax:10116)	289014(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Mechanisms of xenon - and isoflurane-induced preconditioning - a potential link to the cytoskeleton via the MAPKAPK-2 / HSP27 pathway .
19331697	0	HSP27	14,19	NF-kappaB	23,32	HSP27	NF-kappaB	3315	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular_carcinoma cells apoptosis .
15774115	0	HSP27	26,31	P38	90,93	HSP27	P38	3315	1432	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Oxidative stress induced HSP27 expression in human lens epithelial cells is regulated by P38 map kinase -RSB- .
23900529	0	HSP27	31,36	Rac	0,3	HSP27	Rac	3315	207	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets .
23288928	0	HSP27	14,19	Snail	78,83	HSP27	Snail	3315	6615	Gene	Gene	Inhibition|nmod|START_ENTITY blocks|nsubj|Inhibition blocks|advcl|promoting promoting|dobj|degradation degradation|amod|END_ENTITY	Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation .
26348464	0	HSP27	15,20	Snail	82,87	HSP27	Snail	3315	6615	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of HSP27 on Gemcitabine-Resistant Pancreatic_Cancer Cell Line Through Snail .
26348464	0	HSP27	15,20	Snail	82,87	HSP27	Snail	3315	6615	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of HSP27 on Gemcitabine-Resistant Pancreatic_Cancer Cell Line Through Snail .
23804239	0	HSP27	14,19	Toll-like_receptor_3	50,70	HSP27	Toll-like receptor 3	3315	7098	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Extracellular HSP27 mediates angiogenesis through Toll-like_receptor_3 .
22362414	0	HSP27	33,38	androgen_receptor	42,59	HSP27	androgen receptor	3315	367	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of the heat_shock protein HSP27 on androgen_receptor expression and function in prostate_cancer cells .
26151374	0	HSP27	17,22	eIF4E	106,111	HSP27	eIF4E	15507(Tax:10090)	13684(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Unphosphorylated HSP27 -LRB- HSPB1 -RRB- regulates the translation initiation process via a direct association with eIF4E in osteoblasts .
26151374	0	HSP27	17,22	eIF4E	106,111	HSP27	eIF4E	15507(Tax:10090)	13684(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Unphosphorylated HSP27 -LRB- HSPB1 -RRB- regulates the translation initiation process via a direct association with eIF4E in osteoblasts .
17102673	0	HSP27	65,70	heat_shock_protein	45,63	HSP27	heat shock protein	3315	3315	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	UVB irradiation-induced changes in the 27-kd heat_shock_protein -LRB- HSP27 -RRB- in human corneal epithelial cells .
10446196	0	HSP27	21,26	p38	11,14	HSP27	p38	3315	1432	Gene	Gene	pathway|nummod|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	A role for p38 -LRB- MAPK -RRB- / HSP27 pathway in smooth muscle cell migration .
15848222	0	HSP27	31,36	p38	120,123	HSP27	p38	24471(Tax:10116)	81649(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|parataxis|downstream downstream|nmod|kinase kinase|amod|END_ENTITY	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells : function at a point downstream from p38 MAP kinase .
15911090	0	HSP27	0,5	p38	79,82	HSP27	p38	3315	1432	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|modulation modulation|nmod|END_ENTITY	HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun .
17367746	0	HSP27	20,25	p38	100,103	HSP27	p38	3315	1432	Gene	Gene	phosphorylation|nummod|START_ENTITY Characterization|nmod|phosphorylation Characterization|dep|implication implication|nmod|pathway pathway|amod|END_ENTITY	Characterization of HSP27 phosphorylation induced by microtubule interfering agents : implication of p38 signalling pathway .
10679516	0	HSP27	54,59	p38_MAP_kinase	0,14	HSP27	p38 MAP kinase	24471(Tax:10116)	81649(Tax:10116)	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	p38_MAP_kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells .
10843887	0	HSP27	69,74	p38_MAP_kinase	54,68	HSP27	p38 MAP kinase	3315	1432	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Evidence for modulation of smooth muscle force by the p38_MAP_kinase / HSP27 pathway .
18263706	0	HSP27	0,5	p53	16,19	HSP27	p53	3315	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells : p21 upregulation and G2/M phase cell cycle arrest .
17873285	0	HSP32	47,52	heme_oxygenase-1	29,45	HSP32	heme oxygenase-1	3162	3162	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Differential upregulation of heme_oxygenase-1 -LRB- HSP32 -RRB- in glial cells after oxidative stress and in demyelinating_disorders .
8423544	0	HSP32	38,43	heme_oxygenase-1	20,36	HSP32	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Induction of kidney heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA and protein by ischemia/reperfusion : possible role of heme as both promotor of tissue damage and regulator of HSP32 .
8455037	0	HSP32	48,53	heme_oxygenase-1	30,46	HSP32	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Glutathione depletion induces heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA and protein in rat brain .
8667253	0	HSP32	58,63	heme_oxygenase-1	40,56	HSP32	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Renal_ischemia / reperfusion up-regulates heme_oxygenase-1 -LRB- HSP32 -RRB- expression and increases cGMP in rat heart .
8722628	0	HSP32	111,116	heme_oxygenase-1	93,109	HSP32	heme oxygenase-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Stress response of the rat testis : in situ hydridization and immunohistochemical analysis of heme_oxygenase-1 -LRB- HSP32 -RRB- induction by hyperthermia .
9038811	0	HSP32	31,36	heme_oxygenase-1	13,29	HSP32	heme oxygenase-1	3162	3162	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA in skeletal muscle following contractions .
25233908	0	HSP40	19,24	DNAJB13	0,7	HSP40	DNAJB13	81489(Tax:10090)	69387(Tax:10090)	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	DNAJB13 , a type II HSP40 family member , localizes to the spermatids and spermatozoa during mouse spermatogenesis .
14689278	0	HSP40	21,26	HSP70	14,19	HSP40	HSP70	171221	3308	Gene	Gene	Mitochondrial|nummod|START_ENTITY Mitochondrial|nummod|END_ENTITY	Mitochondrial HSP70 , HSP40 , and HSP60 bind to the 3 ' untranslated region of the Murine_hepatitis_virus genome .
24658033	0	HSP40	0,5	pyruvate_kinase_M2	21,39	HSP40	pyruvate kinase M2	171221	5315	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HSP40 interacts with pyruvate_kinase_M2 and regulates glycolysis and cell proliferation in tumor cells .
9722680	0	HSP47	0,5	HSP47	166,171	HSP47	HSP47	871	871	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	HSP47 , a collagen-specific molecular chaperone , delays the secretion of type III procollagen transfected in human embryonic kidney cell line 293 : a possible role for HSP47 in collagen modification .
9722680	0	HSP47	166,171	HSP47	0,5	HSP47	HSP47	871	871	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	HSP47 , a collagen-specific molecular chaperone , delays the secretion of type III procollagen transfected in human embryonic kidney cell line 293 : a possible role for HSP47 in collagen modification .
26335776	0	HSP60	19,24	FUS	0,3	HSP60	FUS	3329	2521	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	FUS Interacts with HSP60 to Promote Mitochondrial Damage .
8596706	0	HSP60	27,32	HSP25	20,25	HSP60	HSP25	63868(Tax:10116)	24471(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Heat_shock proteins HSP25 , HSP60 , HSP72 , HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney .
24058891	0	HSP60	47,52	HSP70	55,60	HSP60	HSP70	3329	3308	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Hyperglycaemia and oxidative stress upregulate HSP60 _ HSP70 expression in HeLa cells .
8596706	0	HSP60	27,32	HSP72	34,39	HSP60	HSP72	63868(Tax:10116)	24472(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Heat_shock proteins HSP25 , HSP60 , HSP72 , HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney .
20501446	0	HSP60	14,19	MK2	36,39	HSP60	MK2	15510(Tax:10090)	17164(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis .
19470374	0	HSP60	0,5	YB-1	21,25	HSP60	YB-1	15510(Tax:10090)	22608(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HSP60 interacts with YB-1 and affects its polysome association and subcellular localization .
19022255	0	HSP60	21,26	c-MYC	41,46	HSP60	c-MYC	3329	4609	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Direct regulation of HSP60 expression by c-MYC induces transformation .
20806039	0	HSP60	34,39	heat_shock_protein	14,32	HSP60	heat shock protein	3329	3329	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Assessment of heat_shock_protein -LRB- HSP60 , HSP72 , HSP90 , and HSC70 -RRB- expression in cultured limbal stem cells following air lifting .
17237417	0	HSP70	75,80	APOBEC3G	94,102	HSP70	APOBEC3G	3308	60489	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4 -LRB- + -RRB- T cells and dendritic cells .
19376117	0	HSP70	0,5	BCL2L12	15,22	HSP70	BCL2L12	3308	83596	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	HSP70 protects BCL2L12 and BCL2L12A from N-terminal ubiquitination-mediated proteasomal degradation .
16970242	0	HSP70	0,5	CA3	36,39	HSP70	CA3	266759(Tax:10116)	54232(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	HSP70 expression in the hippocampal CA3 subfield in different chronic stress models .
17237417	0	HSP70	75,80	CD4	117,120	HSP70	CD4	3308	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 up-regulates APOBEC3G expression in CD4 -LRB- + -RRB- T cells and dendritic cells .
23300563	0	HSP70	0,5	CD4	45,48	HSP70	CD4	3308	920	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|function function|nmod|CD25 CD25|compound|END_ENTITY	HSP70 enhances immunosuppressive function of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T regulatory cells and cytotoxicity in CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells .
10996389	0	HSP70	42,47	EL-4	67,71	HSP70	EL-4	15511(Tax:10090)	111979(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Splenic cytotoxic cells recognize surface HSP70 on culture-adapted EL-4 mouse_lymphoma cells .
19083193	0	HSP70	12,17	ENPP1	21,26	HSP70	ENPP1	3308	5167	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	The role of HSP70 on ENPP1 expression and insulin-receptor activation .
16239242	0	HSP70	13,18	HSC70	49,54	HSP70	HSC70	3308	3312	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cells .
7726639	0	HSP70	50,55	HSC70	92,97	HSP70	HSC70	3308	3312	Gene	Gene	heat_shock_protein_70|appos|START_ENTITY expression|nmod|heat_shock_protein_70 cognate|nsubj|expression cognate|dobj|protein protein|appos|END_ENTITY	Differential expression of heat_shock_protein_70 -LRB- HSP70 -RRB- and heat_shock cognate protein 70 -LRB- HSC70 -RRB- in human epidermis .
12942564	0	HSP70	34,39	HSP27	20,25	HSP70	HSP27	3308	3315	Gene	Gene	HSP60|nummod|START_ENTITY HSP60|nummod|END_ENTITY	Heat_shock proteins HSP27 , HSP60 , HSP70 , and HSP90 : expression in bladder_carcinoma .
15810071	0	HSP70	49,54	HSP27	35,40	HSP70	HSP27	3308	3315	Gene	Gene	HSP90|compound|START_ENTITY HSP60|dep|HSP90 HSP60|compound|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
19350847	0	HSP70	16,21	HSP27	9,14	HSP70	HSP27	3308	3315	Gene	Gene	Elevated|nummod|START_ENTITY Elevated|nummod|END_ENTITY	Elevated HSP27 , HSP70 and HSP90_alpha in chronic_obstructive_pulmonary_disease : markers for immune activation and tissue destruction .
9389084	0	HSP70	41,46	HSP27	48,53	HSP70	HSP27	3308	3315	Gene	Gene	Study|appos|START_ENTITY END_ENTITY|nsubj|Study	Study of heat_shock protein HSP90_alpha , HSP70 , HSP27 mRNA expression in human acute_leukemia cells .
14689278	0	HSP70	14,19	HSP40	21,26	HSP70	HSP40	3308	171221	Gene	Gene	Mitochondrial|nummod|START_ENTITY Mitochondrial|nummod|END_ENTITY	Mitochondrial HSP70 , HSP40 , and HSP60 bind to the 3 ' untranslated region of the Murine_hepatitis_virus genome .
24058891	0	HSP70	55,60	HSP60	47,52	HSP70	HSP60	3308	3329	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Hyperglycaemia and oxidative stress upregulate HSP60 _ HSP70 expression in HeLa cells .
24026294	0	HSP70	119,124	HSP70	36,41	HSP70	HSP70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi .
24026294	0	HSP70	36,41	HSP70	119,124	HSP70	HSP70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of diagnostic ultrasound on HSP70 expression in chorionic villi in rats during early pregnancy and the role of HSP70 in apoptosis in chorionic villi .
2016286	0	HSP70	106,111	HSP90	45,50	HSP70	HSP90	3308	3320	Gene	Gene	proteins|compound|START_ENTITY containing|dobj|proteins exists|advcl|containing exists|nsubj|90-kDa_heat_shock_protein 90-kDa_heat_shock_protein|appos|END_ENTITY	Evidence that the 90-kDa_heat_shock_protein -LRB- HSP90 -RRB- exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000 , 56,000 , and 50,000 .
26731018	0	HSP70	34,39	HSP90	8,13	HSP70	HSP90	15511(Tax:10090)	104434(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY target|nmod|induction target|nsubj|END_ENTITY	Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain .
9389084	0	HSP70	41,46	HSP90_alpha	28,39	HSP70	HSP90 alpha	3308	3320	Gene	Gene	Study|appos|START_ENTITY Study|nmod|END_ENTITY	Study of heat_shock protein HSP90_alpha , HSP70 , HSP27 mRNA expression in human acute_leukemia cells .
23913168	0	HSP70	23,28	Heat_shock_protein_70	0,21	HSP70	Heat shock protein 70	3308	3308	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Heat_shock_protein_70 -LRB- HSP70 -RRB- expression is associated with poor prognosis in intestinal_type_gastric_cancer .
19142233	0	HSP70	46,51	IL-10	0,5	HSP70	IL-10	15511(Tax:10090)	16153(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis .
18348256	0	HSP70	27,32	JNK	51,54	HSP70	JNK	15511(Tax:10090)	26419(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Differential regulation of HSP70 expression by the JNK kinases SEK1 and MKK7 in mouse embryonic_stem cells treated with cadmium .
22409343	0	HSP70	48,53	JNK	13,16	HSP70	JNK	3308	5599	Gene	Gene	signal|nmod|START_ENTITY signal|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia .
22689214	0	HSP70	10,15	JNK	40,43	HSP70	JNK	3308	5599	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of HSP70 and 90 in modulation of JNK , ERK expression in preeclamptic placental endothelial cell .
12969528	0	HSP70	15,20	P-gp	41,45	HSP70	P-gp	3308	5243	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of HSP70 and P-glycoprotein -LRB- P-gp -RRB- in human hepatocarcinoma HepG2 cells induced by heat_shock and inhibiting effect of quercetin on them -RSB- .
24623308	0	HSP70	0,5	PLK1	23,27	HSP70	PLK1	3308	5347	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	HSP70 colocalizes with PLK1 at the centrosome and disturbs spindle dynamics in cells arrested in mitosis by arsenic_trioxide .
17097051	0	HSP70	0,5	SHP2	15,19	HSP70	SHP2	3308	5781	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway .
19243468	0	HSP70	0,5	TRAF2	21,26	HSP70	TRAF2	3308	7186	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon_cancer cells .
25860916	0	HSP70	28,33	VEGFA	50,55	HSP70	VEGFA	15511(Tax:10090)	22339(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol promotes angiogenesis in a mouse model .
26243699	0	HSP70	28,33	VEGFA	50,55	HSP70	VEGFA	15511(Tax:10090)	22339(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
26243699	0	HSP70	28,33	VEGFA	50,55	HSP70	VEGFA	15511(Tax:10090)	22339(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
8141767	0	HSP70	55,60	heat-shock_protein	35,53	HSP70	heat-shock protein	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation of a novel inducible rat heat-shock_protein -LRB- HSP70 -RRB- gene and its expression during ischaemia/hypoxia and heat_shock .
9142686	0	HSP70	91,96	heat-shock_protein	71,89	HSP70	heat-shock protein	3308	3308	Gene	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	Helium-neon laser irradiation is not a stressful treatment : a study on heat-shock_protein -LRB- HSP70 -RRB- level .
8833636	0	HSP70	42,47	heat-shock_protein_70	19,40	HSP70	heat-shock protein 70	3308	3308	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of heat-shock_protein_70 -LRB- HSP70 -RRB- in the mononuclear cells of patients with non-insulin-dependent diabetes_mellitus .
10051078	0	HSP70	42,47	heat_shock_protein_70	19,40	HSP70	heat shock protein 70	3308	3308	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Endotoxin inhibits heat_shock_protein_70 -LRB- HSP70 -RRB- expression in peripheral blood mononuclear cells of patients with severe sepsis .
11566631	0	HSP70	189,194	heat_shock_protein_70	166,187	HSP70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Strain-dependent difference in inducible nitric_oxide synthesis -LRB- iNOS -RRB- expression in rat pancreatic islets correlates with interferon_regulating_factor_1 -LRB- IRF-1 -RRB- and heat_shock_protein_70 -LRB- HSP70 -RRB- expression .
21345207	0	HSP70	50,55	heat_shock_protein_70	27,48	HSP70	heat shock protein 70	3308	3308	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of heat_shock_protein_70 -LRB- HSP70 -RRB- in patients with oral_cancer .
10391364	0	HSP70	93,98	nerve_growth_factor	49,68	HSP70	nerve growth factor	266759(Tax:10116)	310738(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of brain-derived_neurotrophic_factor , nerve_growth_factor , and heat_shock protein HSP70 following fluid percussion brain_injury in rats .
11710946	0	HSP70	87,92	p38	49,52	HSP70	p38	3308	1432	Gene	Gene	induction|nmod|START_ENTITY regulated|dobj|induction kinase|acl|regulated kinase|amod|END_ENTITY	Human keratinocytes respond to osmotic stress by p38 map kinase regulated induction of HSP70 and HSP27 .
9430735	0	HSP70	68,73	p38	0,3	HSP70	p38	3308	5594	Gene	Gene	mRNAs|nmod|START_ENTITY induction|nmod|mRNAs essential|nmod|induction essential|nsubj|activity activity|amod|END_ENTITY	p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells .
10095033	0	HSP70	42,47	p38_MAP_kinase	24,38	HSP70	p38 MAP kinase	266759(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Possible involvement of p38_MAP_kinase in HSP70 expression induced by hypoxia in rat primary astrocytes .
23251530	0	HSP70	61,66	p53	30,33	HSP70	p53	15511(Tax:10090)	22060(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY mechanism|dep|role mechanism|nmod|stabilization stabilization|compound|END_ENTITY	Molecular mechanism of mutant p53 stabilization : the role of HSP70 and MDM2 .
7718482	0	HSP70	48,53	p53	74,77	HSP70	p53	3308	7157	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|genes genes|compound|END_ENTITY	Response of heat_shock element within the human HSP70 promoter to mutated p53 genes .
9235949	0	HSP70	0,5	p53	52,55	HSP70	p53	3308	7157	Gene	Gene	sites|nummod|START_ENTITY sites|nmod|END_ENTITY	HSP70 binding sites in the tumor suppressor protein p53 .
15871184	0	HSP70	1,6	smac	16,20	HSP70	smac	15511(Tax:10090)	66593(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	-LSB- HSP70 inhibits smac release from the mitochondria and protects against H2O2-induced apoptosis in C2C12 myogenic cells -RSB- .
18844219	0	HSP70-2	32,39	HIF-1	43,48	HSP70-2	HIF-1	3306	3091	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia .
19335985	0	HSP70-2	36,43	HIF-1	60,65	HSP70-2	HIF-1	3306	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|-RSB- -RSB-|amod|dependent dependent|amod|END_ENTITY	-LSB- Hypoxia induces heat_shock protein HSP70-2 expression in a HIF-1 dependent manner -RSB- .
7959705	0	HSP70-2	123,130	HLA-linked_heat-shock_protein_70-2	87,121	HSP70-2	HLA-linked heat-shock protein 70-2	3306	3306	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A pentanucleotide tandem duplication polymorphism in the 3 ' untranslated region of the HLA-linked_heat-shock_protein_70-2 -LRB- HSP70-2 -RRB- gene .
19914824	0	HSP70-2	25,32	Heat-shock_protein_70-2	0,23	HSP70-2	Heat-shock protein 70-2	3306	3306	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Heat-shock_protein_70-2 -LRB- HSP70-2 -RRB- expression in bladder urothelial_carcinoma is associated with tumour progression and promotes migration and invasion .
11196683	0	HSP70-2	72,79	heat-shock_protein	52,70	HSP70-2	heat-shock protein	3306	3306	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between the polymorphism at the heat-shock_protein -LRB- HSP70-2 -RRB- gene and systemic_lupus_erythematosus -LRB- SLE -RRB- in the Mexican mestizo population .
18420590	0	HSP70B	67,73	HEP2	42,46	HSP70B	HEP2	5722220(Tax:3055)	5717182(Tax:3055)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Assistance for a chaperone : Chlamydomonas HEP2 activates plastidic HSP70B for cochaperone binding .
25957766	0	HSP70B	39,45	HSPA6	32,37	HSP70B	HSPA6	3311	3310	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of heat_shock protein HSPA6 -LRB- HSP70B ' -RRB- upon HSP90 inhibition in cancer cell lines .
11162511	0	HSP70B	18,24	NFIL6	37,42	HSP70B	NFIL6	3311	1051	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Repression of the HSP70B promoter by NFIL6 , Ku70 , and MAPK involves three complementary mechanisms .
19486887	0	HSP72	21,26	Foxa1	30,35	HSP72	Foxa1	3303	3169	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast_cancer cell line .
8596706	0	HSP72	34,39	HSP25	20,25	HSP72	HSP25	24472(Tax:10116)	24471(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Heat_shock proteins HSP25 , HSP60 , HSP72 , HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney .
8596706	0	HSP72	34,39	HSP60	27,32	HSP72	HSP60	24472(Tax:10116)	63868(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Heat_shock proteins HSP25 , HSP60 , HSP72 , HSP73 in isoosmotic cortex and hyperosmotic medulla of rat kidney .
12207910	0	HSP72	15,20	IL-6	0,4	HSP72	IL-6	3303	3569	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	IL-6 activates HSP72 gene expression in human skeletal muscle .
9191105	0	HSP72	33,38	heat-shock_protein	13,31	HSP72	heat-shock protein	24472(Tax:10116)	24472(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of heat-shock_protein -LRB- HSP72 -RRB- in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino_acids .
19601813	0	HSP90	11,16	AAG	3,6	HSP90	AAG	3320	4350	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	17 AAG for HSP90 inhibition in cancer -- from bench to bedside .
18281495	0	HSP90	13,18	AHA1	31,35	HSP90	AHA1	3320	10598	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin .
15533935	0	HSP90	25,30	ATPase	76,82	HSP90	ATPase	111058(Tax:10090)	13417(Tax:10090)	Gene	Gene	NASP|nmod|START_ENTITY Association|nmod|NASP Association|dep|stimulation stimulation|nmod|activity activity|compound|END_ENTITY	Association of NASP with HSP90 in mouse spermatogenic cells : stimulation of ATPase activity and transport of linker histones into nuclei .
23321985	0	HSP90	35,40	ATPase	25,31	HSP90	ATPase	111058(Tax:10090)	13417(Tax:10090)	Gene	Gene	attenuates|nummod|START_ENTITY END_ENTITY|nmod|attenuates	Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function .
26991466	0	HSP90	4,9	ATPase	45,51	HSP90	ATPase	3320	1769	Gene	Gene	chaperone|compound|START_ENTITY chaperone|dep|END_ENTITY	The HSP90 molecular chaperone - an enigmatic ATPase .
25349783	0	HSP90	87,92	AhR	59,62	HSP90	AhR	3320	196	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	The activation mechanism of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- by molecular chaperone HSP90 .
24922078	0	HSP90	10,15	CD8	58,61	HSP90	CD8	3320	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Defect in HSP90 expression in highly differentiated human CD8 -LRB- + -RRB- T lymphocytes .
27075590	0	HSP90	0,5	COX-2	59,64	HSP90	COX-2	3320	5743	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal_Cancer_Cells .
23241420	0	HSP90	52,57	CYP2E1	27,33	HSP90	CYP2E1	111058(Tax:10090)	13106(Tax:10090)	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	The possible mechanisms of CYP2E1 interactions with HSP90 and the influence of ethanol on them .
15390117	0	HSP90	51,56	GRP94	100,105	HSP90	GRP94	104434(Tax:10090)	22027(Tax:10090)	Gene	Gene	90-kDa_heat_shock_protein|appos|START_ENTITY 90-kDa_heat_shock_protein|appos|END_ENTITY	Glial expression of the 90-kDa_heat_shock_protein -LRB- HSP90 -RRB- and the 94-kDa_glucose-regulated_protein -LRB- GRP94 -RRB- following an excitotoxic lesion in the mouse hippocampus .
15810071	0	HSP90	56,61	GRP94	70,75	HSP90	GRP94	3320	7184	Gene	Gene	HSP60|dep|START_ENTITY HSP60|dep|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
21323861	0	HSP90	16,21	Grp94	111,116	HSP90	Grp94	3320	7184	Gene	Gene	START_ENTITY|nmod|promotion promotion|nmod|effect effect|nmod|glucose-regulated_protein94 glucose-regulated_protein94|appos|END_ENTITY	Crucial role of HSP90 in the Akt-dependent promotion of angiogenic-like effect of glucose-regulated_protein94 -LRB- Grp94 -RRB- - IgG complexes .
15810071	0	HSP90	56,61	HSP27	35,40	HSP90	HSP27	3320	3315	Gene	Gene	HSP60|dep|START_ENTITY HSP60|compound|END_ENTITY	Expression of heat_shock proteins -LRB- HSP27 , HSP60 , HSP70 , HSP90 , GRP78 , GRP94 -RRB- in hepatitis_B_virus-related hepatocellular_carcinomas and dysplastic_nodules .
25202074	0	HSP90	63,68	HSP27	0,5	HSP90	HSP27	3320	3315	Gene	Gene	inhibitors|compound|START_ENTITY produces|nmod|inhibitors produces|nsubj|knockdown knockdown|compound|END_ENTITY	HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma_multiforme .
2016286	0	HSP90	45,50	HSP70	106,111	HSP90	HSP70	3320	3308	Gene	Gene	90-kDa_heat_shock_protein|appos|START_ENTITY exists|nsubj|90-kDa_heat_shock_protein exists|advcl|containing containing|dobj|proteins proteins|compound|END_ENTITY	Evidence that the 90-kDa_heat_shock_protein -LRB- HSP90 -RRB- exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000 , 56,000 , and 50,000 .
26731018	0	HSP90	8,13	HSP70	34,39	HSP90	HSP70	104434(Tax:10090)	15511(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|induction induction|compound|END_ENTITY	Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain .
23261432	0	HSP90	23,28	Heat_shock_protein_90	0,21	HSP90	Heat shock protein 90	104434(Tax:10090)	104434(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Heat_shock_protein_90 -LRB- HSP90 -RRB- inhibitors activate the heat_shock factor 1 -LRB- HSF1 -RRB- stress response pathway and improve glucose regulation in diabetic mice .
21478269	0	HSP90	55,60	MDM2	38,42	HSP90	MDM2	3320	4193	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells .
12869560	0	HSP90	28,33	P2X7_receptor	45,58	HSP90	P2X7 receptor	3320	5027	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Tyrosine phosphorylation of HSP90 within the P2X7_receptor complex negatively regulates P2X7_receptors .
17244529	0	HSP90	20,25	RACK1	0,5	HSP90	RACK1	3320	10399	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O -LRB- 2 -RRB- - independent and HSP90 inhibitor-induced degradation of HIF-1alpha .
12621024	0	HSP90	93,98	Ral-binding_protein_1	21,42	HSP90	Ral-binding protein 1	111058(Tax:10090)	19765(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	HSF-1 interacts with Ral-binding_protein_1 in a stress-responsive , multiprotein complex with HSP90 in vivo .
14761955	0	HSP90	17,22	Sgt1	6,10	HSP90	Sgt1	3320	10910	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain .
25349783	0	HSP90	87,92	aryl_hydrocarbon_receptor	32,57	HSP90	aryl hydrocarbon receptor	3320	196	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The activation mechanism of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- by molecular chaperone HSP90 .
16895583	0	HSP90	54,59	glucocorticoid_receptor	30,53	HSP90	glucocorticoid receptor	3320	2908	Gene	Gene	expression|compound|START_ENTITY regulation|dep|expression regulation|nmod|END_ENTITY	Region-specific regulation of glucocorticoid_receptor / HSP90 expression and interaction in brain .
20444924	0	HSP90	32,37	heat_shock_protein_90	9,30	HSP90	heat shock protein 90	3320	3320	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	RET is a heat_shock_protein_90 -LRB- HSP90 -RRB- client protein and is knocked down upon HSP90 pharmacological block .
21219297	0	HSP90	37,42	heat_shock_protein_90	14,35	HSP90	heat shock protein 90	3320	3320	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of heat_shock_protein_90 -LRB- HSP90 -RRB- as a therapeutic strategy for the treatment of myeloma and other cancers .
24831003	0	HSP90	149,154	heat_shock_protein_90	126,147	HSP90	heat shock protein 90	3320	3320	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Identification of mixed_lineage_leukemia_1 -LRB- MLL1 -RRB- protein as a coactivator of heat_shock_factor_1 -LRB- HSF1 -RRB- protein in response to heat_shock_protein_90 -LRB- HSP90 -RRB- inhibition .
21478269	0	HSP90	55,60	p53	101,104	HSP90	p53	3320	7157	Gene	Gene	inactivation|nmod|START_ENTITY causes|nsubj|inactivation causes|dobj|stabilization stabilization|nmod|END_ENTITY	Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells .
24689038	0	HSP90	38,43	thioredoxin-1	10,23	HSP90	thioredoxin-1	3320	7295	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Decreased thioredoxin-1 and increased HSP90 expression in skeletal muscle in subjects with type 2 diabetes or impaired_glucose_tolerance .
14724288	0	HSP90A	21,27	c-Myc	45,50	HSP90A	c-Myc	3320	4609	Gene	Gene	transcription|nummod|START_ENTITY transcription|nmod|END_ENTITY	Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation .
22363530	0	HSP90B1	70,77	decorin	45,52	HSP90B1	decorin	7184	1634	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Proteomic analyses reveal high expression of decorin and endoplasmin -LRB- HSP90B1 -RRB- are associated with breast_cancer metastasis and decreased survival .
19526558	0	HSP90C	207,213	vesicle-inducing_protein_in_plastids_1	131,169	HSP90C	vesicle-inducing protein in plastids 1	5728553(Tax:3055)	5719360(Tax:3055)	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Application of quantitative immunoprecipitation combined with knockdown and cross-linking to Chlamydomonas reveals the presence of vesicle-inducing_protein_in_plastids_1 in a common complex with chloroplast HSP90C .
9389084	0	HSP90_alpha	28,39	HSP27	48,53	HSP90 alpha	HSP27	3320	3315	Gene	Gene	Study|nmod|START_ENTITY END_ENTITY|nsubj|Study	Study of heat_shock protein HSP90_alpha , HSP70 , HSP27 mRNA expression in human acute_leukemia cells .
9389084	0	HSP90_alpha	28,39	HSP70	41,46	HSP90 alpha	HSP70	3320	3308	Gene	Gene	Study|nmod|START_ENTITY Study|appos|END_ENTITY	Study of heat_shock protein HSP90_alpha , HSP70 , HSP27 mRNA expression in human acute_leukemia cells .
25043441	0	HSPA2	37,42	heat-shock_protein_A2	14,35	HSPA2	heat-shock protein A2	60460(Tax:10116)	60460(Tax:10116)	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of heat-shock_protein_A2 -LRB- HSPA2 -RRB- in male rats before and after varicocele induction .
25957766	0	HSPA6	32,37	HSP70B	39,45	HSPA6	HSP70B	3310	3311	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of heat_shock protein HSPA6 -LRB- HSP70B ' -RRB- upon HSP90 inhibition in cancer cell lines .
17785435	0	HSPA8	40,45	CD316	6,11	HSPA8	CD316	3312	93185	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	EWI-2 / CD316 is an inducible receptor of HSPA8 on human dendritic cells .
17785435	0	HSPA8	40,45	EWI-2	0,5	HSPA8	EWI-2	3312	93185	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	EWI-2 / CD316 is an inducible receptor of HSPA8 on human dendritic cells .
21530495	0	HSPA9	71,76	ATPase	77,83	HSPA9	ATPase	3313	1769	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	A conserved histidine in human DNLZ/HEP is required for stimulation of HSPA9 ATPase activity .
26598328	0	HSPA9	40,45	heat-shock_protein_A9	17,38	HSPA9	heat-shock protein A9	3313	3313	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the heat-shock_protein_A9 -LRB- HSPA9 -RRB- gene cause the EVEN-PLUS_syndrome of congenital_malformations and skeletal_dysplasia .
26805817	0	HSPB1	67,72	Heat_Shock_Protein_27	44,65	HSPB1	Heat Shock Protein 27	3315	3315	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	The Clinical Significance of Phosphorylated Heat_Shock_Protein_27 -LRB- HSPB1 -RRB- in Pancreatic_Cancer .
22222935	0	HSPB1	33,38	Hsp27	26,31	HSPB1	Hsp27	3315	3315	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Plasma Hsp72 -LRB- HSPA1A -RRB- and Hsp27 -LRB- HSPB1 -RRB- expression under heat stress : influence of exercise intensity .
24982356	0	HSPB1	19,24	miR-1	45,50	HSPB1	miR-1	3315	79187	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate_cancer cells .
24223153	0	HSPB6	45,50	phosphoinositide_3-kinase	57,82	HSPB6	phosphoinositide 3-kinase	126393	5295	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Direct association of heat_shock protein 20 -LRB- HSPB6 -RRB- with phosphoinositide_3-kinase -LRB- PI3K -RRB- in human hepatocellular_carcinoma : regulation of the PI3K activity .
26929074	0	HSPB7	0,5	FLNC	31,35	HSPB7	FLNC	29818(Tax:10090)	68794(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles .
11590142	0	HSPC021	18,25	Int-6	41,46	HSPC021	Int-6	51386	3646	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic_translation_initiation_factor_3 .
19576655	0	HSPC300	69,76	WAVE2	106,111	HSPC300	WAVE2	55845	10163	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Metastatic potential of lung_squamous_cell_carcinoma associated with HSPC300 through its interaction with WAVE2 .
8404044	0	HSPCAL4	49,56	hsp90_alpha	36,47	HSPCAL4	hsp90 alpha	3320	3320	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mapping the intron-containing human hsp90_alpha -LRB- HSPCAL4 -RRB- gene to chromosome band 14q32 .
25506707	0	HSPD1	0,5	IRF3	21,25	HSPD1	IRF3	3329	3661	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	HSPD1 Interacts with IRF3 to Facilitate Interferon-Beta Induction .
8975727	0	HSPF1	63,68	Hsp40	50,55	HSPF1	Hsp40	3337	3337	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic cloning of a human heat_shock protein 40 -LRB- Hsp40 -RRB- gene -LRB- HSPF1 -RRB- and its chromosomal localization to 19p13 .2 .
24415158	0	HSPG	50,54	Osteoactivin	0,12	HSPG	Osteoactivin	15529(Tax:10090)	93695(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Osteoactivin promotes osteoblast adhesion through HSPG and avb1 integrin .
20638466	0	HSPG	51,55	heparan_sulfate_proteoglycan	21,49	HSPG	heparan sulfate proteoglycan	960	960	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glial cells modulate heparan_sulfate_proteoglycan -LRB- HSPG -RRB- expression by neuronal precursors during early postnatal cerebellar development .
16309579	0	HSP_70	80,86	heat_shock_protein_70	57,78	HSP 70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II type I antagonist on oxidative stress and heat_shock_protein_70 -LRB- HSP_70 -RRB- expression in obstructive nephropathy .
2555773	0	HSP_70	77,83	topoisomerase_1	15,30	HSP 70	topoisomerase 1	44920(Tax:7227)	32458(Tax:7227)	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Interaction of topoisomerase_1 with the transcribed region of the Drosophila HSP_70 heat_shock gene .
9211983	0	HSRP1	56,61	p120	36,40	HSRP1	p120	3839	4839	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human proliferation-related protein p120 interacts with HSRP1 .
15116099	0	HST-1	0,5	FGF-4	6,11	HST-1	FGF-4	109727(Tax:10090)	14175(Tax:10090)	Gene	Gene	START_ENTITY|appos|plays plays|nsubj|END_ENTITY	HST-1 / FGF-4 plays a critical role in crypt cell survival and facilitates epithelial cell restitution and proliferation .
7635948	0	HST-1	87,92	FGF-4	94,99	HST-1	FGF-4	109727(Tax:10090)	14175(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 -LRB- FGF-4 -RRB- gene .
7809043	0	HST-1	36,41	FGF4	43,47	HST-1	FGF4	109727(Tax:10090)	14175(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Adenovirus-mediated transfer of the HST-1 -LRB- FGF4 -RRB- gene induces increased levels of platelet count in vivo .
8841381	0	HT1080	67,73	p53	46,49	HT1080	p53	8872	7157	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	HSP binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines .
12447999	0	HT1080	91,97	vitronectin	25,36	HT1080	vitronectin	8872	7448	Gene	Gene	cell|compound|START_ENTITY cell|amod|END_ENTITY	Both u-PA inhibition and vitronectin binding by plasminogen_activator_inhibitor_1 regulate HT1080 fibrosarcoma cell metastasis .
8390454	0	HT2	177,180	IL-4_receptor	69,82	HT2	IL-4 receptor	109524(Tax:10090)	16190(Tax:10090)	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
17695512	0	HTERT	0,5	matrix_metalloproteinase-1_and_vascular_endothelial_growth_factor	38,103	HTERT	matrix metalloproteinase-1 and vascular endothelial growth factor	7015	4312;7422	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|expression expression|amod|END_ENTITY	HTERT mRNA expression correlates with matrix_metalloproteinase-1_and_vascular_endothelial_growth_factor expression in human breast_cancer : a correlative study using RT-PCR .
11571756	0	HTL1	4,8	YCR020W-b	15,24	HTL1	YCR020W-b	850384(Tax:4932)	850384(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The HTL1 gene -LRB- YCR020W-b -RRB- of Saccharomyces_cerevisiae is necessary for growth at 37 degrees C , and for the conservation of chromosome stability and fertility .
17028323	0	HTR12	39,44	centromeric_histone_H3	15,37	HTR12	centromeric histone H3	839104(Tax:3702)	839104(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Duplication of centromeric_histone_H3 -LRB- HTR12 -RRB- gene in Arabidopsis halleri and A. lyrata , plant species with multiple centromeric satellite sequences .
8333729	0	HTR1A	102,107	5HT1a_receptor	81,95	HTR1A	5HT1a receptor	3350	3350	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Segregation and linkage analysis in five manic_depression pedigrees excludes the 5HT1a_receptor gene -LRB- HTR1A -RRB- .
11247661	0	HTR1B	54,59	serotonin_receptor_1B	31,52	HTR1B	serotonin receptor 1B	3351	3351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic diversity of the human serotonin_receptor_1B -LRB- HTR1B -RRB- gene .
12437478	0	HTR1B	73,78	serotonin_receptor_1B	50,71	HTR1B	serotonin receptor 1B	3351	3351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA variation and psychopharmacology of the human serotonin_receptor_1B -LRB- HTR1B -RRB- gene .
14593427	0	HTR1B	80,85	serotonin_receptor_1B	57,78	HTR1B	serotonin receptor 1B	3351	3351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the 5 ' - untranslated region of the human serotonin_receptor_1B -LRB- HTR1B -RRB- gene affect gene expression .
8001977	0	HTR1E	75,80	5-HT1E	36,42	HTR1E	5-HT1E	3354	3354	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
8001977	0	HTR1E	75,80	S31	63,66	HTR1E	S31	3354	3354	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
22661198	0	HTR2A	28,33	Serotonin_2A_receptor	0,21	HTR2A	Serotonin 2A receptor	3356	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonin_2A_receptor gene -LRB- HTR2A -RRB- polymorphism in alcohol-dependent patients .
24968012	0	HTR2A	28,33	Serotonin_2A_receptor	0,21	HTR2A	Serotonin 2A receptor	3356	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonin_2A_receptor gene -LRB- HTR2A -RRB- regulatory variants : possible association with severity of depression symptoms in children with autism_spectrum_disorder .
12167522	0	HTR2A	48,53	serotonin-2A_receptor	20,41	HTR2A	serotonin-2A receptor	3356	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism of the serotonin-2A_receptor gene -LRB- HTR2A -RRB- associated with childhood attention_deficit_hyperactivity_disorder -LRB- ADHD -RRB- in adult women with seasonal_affective_disorder .
26738766	0	HTR2A	74,79	serotonin_2A_receptor	46,67	HTR2A	serotonin 2A receptor	3356	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and expression of the human serotonin_2A_receptor gene -LRB- HTR2A -RRB- locus : identification of novel HTR2A and antisense -LRB- HTR2A-AS1 -RRB- exons .
16697352	0	HTR2A	84,89	serotonin_5-HT2A_receptor	52,77	HTR2A	serotonin 5-HT2A receptor	3356	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the regulatory region of the human serotonin_5-HT2A_receptor gene -LRB- HTR2A -RRB- influence gene expression .
18006541	0	HTR2A	58,63	serotonin_5-HT2A_receptor	26,51	HTR2A	serotonin 5-HT2A receptor	3356	3356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variations in the serotonin_5-HT2A_receptor gene -LRB- HTR2A -RRB- are associated with rheumatoid_arthritis .
23774082	0	HTR2B	68,73	serotonin_receptor_2B	45,66	HTR2B	serotonin receptor 2B	3357	3357	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between a polymorphism in the serotonin_receptor_2B -LRB- HTR2B -RRB- gene and personality traits in healthy Japanese subjects .
7557992	0	HTR2C	110,115	5-HT2c	88,94	HTR2C	5-HT2c	3358	3358	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification , expression , and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene -LRB- HTR2C -RRB- .
14557147	0	HTR3A	45,50	serotonin_receptor_3A	22,43	HTR3A	serotonin receptor 3A	3359	3359	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism in the serotonin_receptor_3A -LRB- HTR3A -RRB- gene and its association with harm avoidance in women .
23963851	0	HTRA1	75,80	high-temperature_requirement_A_serine_peptidase_1	24,73	HTRA1	high-temperature requirement A serine peptidase 1	5654	5654	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation of the high-temperature_requirement_A_serine_peptidase_1 -LRB- HTRA1 -RRB- gene in a Chinese family with cerebral_autosomal_recessive_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy -LRB- CARASIL -RRB- .
22556410	0	HTRA1	76,81	high_temperature_requirement_serine_protease_A1	27,74	HTRA1	high temperature requirement serine protease A1	5654	5654	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Detrimental role for human high_temperature_requirement_serine_protease_A1 -LRB- HTRA1 -RRB- in the pathogenesis of intervertebral disc -LRB- IVD -RRB- degeneration .
20238298	0	HTRA1	8,13	serine_protease	17,32	HTRA1	serine protease	56213(Tax:10090)	50908(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of HTRA1 , a serine_protease , in the progression of articular cartilage degeneration .
21636527	0	HTT	10,13	HIP14	85,90	HTT	HIP14	15194(Tax:10090)	320150(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14 .
19818099	0	HTm4	38,42	MS4A3	44,49	HTm4	MS4A3	170813(Tax:10090)	170813(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Characterization of the expression of HTm4 -LRB- MS4A3 -RRB- , a cell cycle regulator , in human peripheral blood cells and normal and malignant tissues .
26347501	0	HULC	34,38	CUDR	19,23	HULC	CUDR	728655	652995	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Long noncoding RNA CUDR regulates HULC and b-Catenin to govern human liver stem cell malignant differentiation .
26347501	0	HULC	34,38	CUDR	19,23	HULC	CUDR	728655	652995	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Long noncoding RNA CUDR regulates HULC and b-Catenin to govern human liver stem cell malignant differentiation .
25592151	0	HULC	19,23	RXRA	104,108	HULC	RXRA	728655	6256	Gene	Gene	Modulates|nsubj|START_ENTITY Modulates|nmod|Pathway Pathway|compound|END_ENTITY	Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9-Mediated RXRA Signaling Pathway .
26540633	0	HULC	20,24	sphingosine_kinase_1	86,106	HULC	sphingosine kinase 1	728655	8877	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Long non-coding RNA HULC promotes tumor angiogenesis in liver_cancer by up-regulating sphingosine_kinase_1 -LRB- SPHK1 -RRB- .
12114777	0	HUMARA	77,83	Androgen_Receptor	58,75	HUMARA	Androgen Receptor	367	367	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Clonality Analysis of Benign Parathyroid Lesions by Human Androgen_Receptor -LRB- HUMARA -RRB- Gene Assay .
7772520	0	HUMARA	193,199	androgen-receptor	174,191	HUMARA	androgen-receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clonal analysis of peripheral blood and haemopoietic colonies in patients with aplastic_anaemia and refractory_anaemia using the polymorphic short tandem repeat on the human androgen-receptor -LRB- HUMARA -RRB- gene .
10821498	0	HUMARA	179,185	androgen_receptor	155,172	HUMARA	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular evidence that the stromal and epithelial cells in pleomorphic_adenomas of salivary gland arise from the same origin : clonal analysis using human androgen_receptor gene -LRB- HUMARA -RRB- assay .
11444663	0	HUMARA	84,90	androgen_receptor	60,77	HUMARA	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Automated fluorescence analysis of CAG repeats at the human androgen_receptor gene -LRB- HUMARA -RRB- : evaluation of polymorphism in an Italian sample and report of a new allele .
9232621	0	HUMARA	88,94	androgen_receptor	64,81	HUMARA	androgen receptor	367	367	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Clonal X-inactivation analysis of human tumours using the human androgen_receptor gene -LRB- HUMARA -RRB- polymorphism : a non-radioactive and semiquantitative strategy applicable to fresh and archival tissue .
9729823	0	HUMARA	114,120	androgen_receptor	90,107	HUMARA	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Development of a highly polymorphic STR marker for identity testing purposes at the human androgen_receptor gene -LRB- HUMARA -RRB- .
9778630	0	HUMARA	119,125	androgen_receptor	95,112	HUMARA	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Clonal composition of malignant_fibrous_histiocytoma : analysis by PCR-based assay of the human androgen_receptor gene -LRB- HUMARA -RRB- .
18321990	0	HURP	35,39	Aurora_A	0,8	HURP	Aurora A	9787	6790	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Aurora_A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain .
24342616	0	HUWE1	0,5	BRCA1	21,26	HUWE1	BRCA1	10075	672	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway .
24472556	0	HUWE1	0,5	BRCA1	21,26	HUWE1	BRCA1	10075	672	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway .
22754359	0	HUWE1	28,33	CTCF	52,56	HUWE1	CTCF	10075	10664	Gene	Gene	Interactions|compound|START_ENTITY Interactions|nmod|END_ENTITY	Characterization of ARF-BP1 / HUWE1 Interactions with CTCF , MYC , ARF and p53 in MYC-Driven B Cell Neoplasms .
23067542	0	HVEM	68,72	BTLA	48,52	HVEM	BTLA	8764	151888	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	The intrahepatic expression and distribution of BTLA and its ligand HVEM in patients with HBV-related acute-on-chronic_liver_failure .
24205057	0	HVEM	22,26	BTLA	0,4	HVEM	BTLA	230979(Tax:10090)	208154(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	BTLA interaction with HVEM expressed on CD8 -LRB- + -RRB- T cells promotes survival and memory generation in response to a bacterial_infection .
9223502	0	HVEM	63,67	Glycoprotein_D	0,14	HVEM	Glycoprotein D	8764	2532	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Glycoprotein_D of herpes simplex virus -LRB- HSV -RRB- binds directly to HVEM , a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry .
12368332	0	HVEM	125,129	glycoprotein_D	53,67	HVEM	glycoprotein D	8764	2532	Gene	Gene	site|appos|START_ENTITY END_ENTITY|dobj|site	Structure-based analysis of the herpes_simplex_virus glycoprotein_D binding site present on herpesvirus entry mediator HveA -LRB- HVEM -RRB- .
24314649	0	HVEM	109,113	glycoprotein_D	78,92	HVEM	glycoprotein D	8764	2532	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|advcl|binding	Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein_D upon binding to HVEM and nectin-1 .
9557640	0	HVEM	106,110	glycoprotein_D	70,84	HVEM	glycoprotein D	8764	2532	Gene	Gene	binding|nmod|START_ENTITY block|xcomp|binding END_ENTITY|ccomp|block	Monoclonal antibodies to distinct sites on herpes_simplex_virus -LRB- HSV -RRB- glycoprotein_D block HSV binding to HVEM .
19895317	0	HVEM	43,47	herpes_virus_entry_mediator	14,41	HVEM	herpes virus entry mediator	8764	8764	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of herpes_virus_entry_mediator -LRB- HVEM -RRB- in the cornea and trigeminal_ganglia of normal and HSV-1 infected mice .
19701890	0	HVEM	11,15	lymphotoxin-beta_receptor	25,50	HVEM	lymphotoxin-beta receptor	8764	4055	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for HVEM , but not lymphotoxin-beta_receptor , in LIGHT-induced tumor cell death and chemokine production .
7530615	0	HXB	33,36	tenascin	18,26	HXB	tenascin	397460(Tax:9823)	102160657	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the tenascin gene -LRB- HXB -RRB- to swine chromosome 1q21 .1 -- > q21 .3 by fluorescence in situ hybridization .
3905511	0	HXK2	56,60	hexokinase_PII	35,49	HXK2	hexokinase PII	852639(Tax:4932)	852639(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The primary structure of the yeast hexokinase_PII gene -LRB- HXK2 -RRB- which is responsible for glucose repression .
22766018	0	HY1	0,3	GBF1	31,35	HY1	GBF1	817208(Tax:3702)	829826(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HY1 genetically interacts with GBF1 and regulates the activity of the Z-box containing promoters in light signaling pathways in Arabidopsis_thaliana .
26363272	0	HY5	20,23	BZR1	0,4	HY5	BZR1	830996(Tax:3702)	843845(Tax:3702)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	BZR1 Interacts with HY5 to Mediate Brassinosteroid - and Light-Regulated Cotyledon Opening in Arabidopsis in Darkness .
12061902	0	HY5	76,79	COP1	95,99	HY5	COP1	830996(Tax:3702)	817857(Tax:3702)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	HFR1 , a phytochrome_A-signalling component , acts in a separate pathway from HY5 , downstream of COP1 in Arabidopsis_thaliana .
22692212	0	HY5	36,39	GBF1	26,30	HY5	GBF1	830996(Tax:3702)	829826(Tax:3702)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Molecular interactions of GBF1 with HY5 and HYH proteins during light-mediated seedling development in Arabidopsis_thaliana .
23733077	0	HY5	52,55	HYH	47,50	HY5	HYH	830996(Tax:3702)	821027(Tax:3702)	Gene	Gene	HOMOLOG|compound|START_ENTITY END_ENTITY|appos|HOMOLOG	Molecular interactions of BBX24 and BBX25 with HYH , HY5 HOMOLOG , to modulate Arabidopsis seedling development .
21715650	0	HY5	34,37	MSBP1	12,17	HY5	MSBP1	830996(Tax:3702)	835300(Tax:3702)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation .
26474641	0	HY5	20,23	SHW1	0,4	HY5	SHW1	830996(Tax:3702)	843330(Tax:3702)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	SHW1 Interacts with HY5 and COP1 , and Promotes COP1-mediated Degradation of HY5 During Arabidopsis Seedling Development .
21695196	0	HYAL-1	57,63	hyaluronidase-1	40,55	HYAL-1	hyaluronidase-1	3373	3373	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Subtype specific elevated expression of hyaluronidase-1 -LRB- HYAL-1 -RRB- in epithelial_ovarian_cancer .
23733077	0	HYH	47,50	HY5	52,55	HYH	HY5	821027(Tax:3702)	830996(Tax:3702)	Gene	Gene	START_ENTITY|appos|HOMOLOG HOMOLOG|compound|END_ENTITY	Molecular interactions of BBX24 and BBX25 with HYH , HY5 HOMOLOG , to modulate Arabidopsis seedling development .
18632569	0	HYL1	25,29	DCL1	90,94	HYL1	DCL1	837498(Tax:3702)	839574(Tax:3702)	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|END_ENTITY	The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1 .
24361604	0	HYPK	100,104	HSF1	32,36	HYPK	HSF1	25764	3297	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Heat shock transcription factor HSF1 regulates the expression of the Huntingtin-interacting protein HYPK .
24465598	0	HYPK	28,32	Heat_Shock_Factor_1	36,55	HYPK	Heat Shock Factor 1	25764	3297	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcription regulation of HYPK by Heat_Shock_Factor_1 .
17947297	0	HYPK	0,4	Huntingtin	8,18	HYPK	Huntingtin	67693(Tax:10090)	15194(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	HYPK , a Huntingtin interacting protein , reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity .
25446099	0	HYPK	18,22	Huntingtin	72,82	HYPK	Huntingtin	25764	3064	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Chaperone protein HYPK interacts with the first 17 amino_acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity .
16274703	0	Ha-ras	99,105	NFkappaB	87,95	Ha-ras	NFkappaB	15461(Tax:10090)	18033(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Dominant-negative Rac1 suppresses Ras-induced apoptosis possibly through activation of NFkappaB in Ha-ras oncogene-transformed NIH/3T3 cells .
19182994	0	Ha-ras	0,6	Stat3	24,29	Ha-ras	Stat3	15461(Tax:10090)	6774	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell .
2169737	0	Ha-ras	71,77	gelsolin	9,17	Ha-ras	gelsolin	15461(Tax:10090)	227753(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Elevated gelsolin and alpha-actin expression in a flat revertant R1 of Ha-ras oncogene-transformed NIH/3T3 cells .
6611509	0	Ha-ras	53,59	p21	60,63	Ha-ras	p21	15461(Tax:10090)	12575(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein .
8876671	0	Ha-ras	157,163	p21	164,167	Ha-ras	p21	15461(Tax:10090)	12575(Tax:10090)	Gene	Gene	localization|compound|START_ENTITY localization|amod|END_ENTITY	Protection against malignant conversion in SENCAR mouse skin by all trans retinoic_acid : inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization .
11504737	0	Haa1	0,4	Ace1	72,76	Haa1	Ace1	856117(Tax:4932)	852710(Tax:4932)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Haa1 , a protein homologous to the copper-regulated transcription factor Ace1 , is a novel transcriptional activator .
14613483	0	Haematopoietic_protein_tyrosine_phosphatase	0,43	HePTP	45,50	Haematopoietic protein tyrosine phosphatase	HePTP	5786	5786	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Haematopoietic_protein_tyrosine_phosphatase -LRB- HePTP -RRB- phosphorylation by cAMP-dependent protein kinase in T-cells : dynamics and subcellular location .
17933770	0	Haeme-oxygenase_1	116,133	p53	146,149	Haeme-oxygenase 1	p53	15368(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	p53-dependent stimulation of redox-related genes in the lymphoid organs of gamma-irradiated -- mice identification of Haeme-oxygenase_1 as a direct p53 target gene .
6411770	0	Hageman_factor	25,39	Factor_XII	41,51	Hageman factor	Factor XII	306761(Tax:10116)	306761(Tax:10116)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis and release of Hageman_factor -LRB- Factor_XII -RRB- by the isolated perfused rat liver .
6455951	0	Hageman_factor	15,29	HMW	53,56	Hageman factor	HMW	2161	57587	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Mechanisms for Hageman_factor activation and role of HMW kininogen as a coagulation cofactor .
16638441	0	Hageman_factor	50,64	coagulation_factor_XII	26,48	Hageman factor	coagulation factor XII	2161	2161	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Missense mutations in the coagulation_factor_XII -LRB- Hageman_factor -RRB- gene in hereditary_angioedema with normal C1 inhibitor .
2019789	0	Hageman_factor	35,49	factor_XII	23,33	Hageman factor	factor XII	306761(Tax:10116)	306761(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of factor_XII -LRB- Hageman_factor -RRB- in isolated livers of estrogen - and prolactin-treated rats .
3875484	0	Hageman_factor	50,64	kallikrein	69,79	Hageman factor	kallikrein	2161	9622	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Surface-dependent activation of human factor XII -LRB- Hageman_factor -RRB- by kallikrein and its light chain .
23702391	0	Hairless	0,8	Msx2	38,42	Hairless	Msx2	15460(Tax:10090)	17702(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Hairless down-regulates expression of Msx2 and its related target genes in hair follicles .
21558373	0	Hand2	46,51	Dlx6	27,31	Hand2	Dlx6	15111(Tax:10090)	13396(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis .
19607825	0	Hand2	14,19	Pbx	0,3	Hand2	Pbx	58150(Tax:7955)	170445(Tax:7955)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Pbx acts with Hand2 in early myocardial_differentiation .
11751848	0	Hap1	94,98	Hsp90	24,29	Hap1	Hsp90	850958(Tax:4932)	855836(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1 .
12897155	0	Hap1	156,160	Hsp90	102,107	Hap1	Hsp90	9001	3320	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1 .
15102838	0	Hap1	53,57	Hsp90	85,90	Hap1	Hsp90	850958(Tax:4932)	855836(Tax:4932)	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	A novel mode of chaperone action : heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex .
25140128	0	Haptoglobin	0,11	Apolipoprotein_E	64,80	Haptoglobin	Apolipoprotein E	24464(Tax:10116)	25728(Tax:10116)	Gene	Gene	increases|compound|START_ENTITY hippocampus|nsubj|increases hippocampus|dobj|trafficking trafficking|amod|END_ENTITY	Haptoglobin increases with age in rat hippocampus and modulates Apolipoprotein_E mediated cholesterol trafficking in neuroblastoma cell lines .
17824618	0	Haptoglobin	0,11	apolipoprotein_A-I	23,41	Haptoglobin	apolipoprotein A-I	3240	335	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Haptoglobin binding to apolipoprotein_A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase .
19457062	0	Haptoglobin	0,11	apolipoprotein_E	18,34	Haptoglobin	apolipoprotein E	3240	348	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|esterification esterification|amod|END_ENTITY	Haptoglobin binds apolipoprotein_E and influences cholesterol esterification in the cerebrospinal fluid .
19758344	0	Haptoglobin	0,11	apolipoprotein_E	46,62	Haptoglobin	apolipoprotein E	3240	348	Gene	Gene	binds|compound|START_ENTITY binds|dep|END_ENTITY	Haptoglobin binds the antiatherogenic protein apolipoprotein_E - impairment of apolipoprotein_E stimulation of both lecithin : cholesterol_acyltransferase activity and cholesterol uptake by hepatocytes .
19758344	0	Haptoglobin	0,11	apolipoprotein_E	79,95	Haptoglobin	apolipoprotein E	3240	348	Gene	Gene	binds|compound|START_ENTITY binds|dep|impairment impairment|nmod|stimulation stimulation|amod|END_ENTITY	Haptoglobin binds the antiatherogenic protein apolipoprotein_E - impairment of apolipoprotein_E stimulation of both lecithin : cholesterol_acyltransferase activity and cholesterol uptake by hepatocytes .
25058565	0	Haptoglobin	0,11	apolipoprotein_E	27,43	Haptoglobin	apolipoprotein E	3240	348	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Haptoglobin interacts with apolipoprotein_E and beta-amyloid and influences their crosstalk .
809968	0	Haptoglobin	0,11	glucose-6-phosphate_dehydrogenase	79,112	Haptoglobin	glucose-6-phosphate dehydrogenase	3240	2539	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Haptoglobin , hemopexin , hemoglobin and hematocrit in newborns with erythrocyte glucose-6-phosphate_dehydrogenase deficiency .
22707233	0	Haptoglobin	0,11	haptoglobin	105,116	Haptoglobin	haptoglobin	24464(Tax:10116)	24464(Tax:10116)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Haptoglobin and the inflammatory and oxidative status in experimental diabetic rats : antioxidant role of haptoglobin .
11389553	0	Haptoglobin	0,11	lecithin-cholesterol_acyltransferase	21,57	Haptoglobin	lecithin-cholesterol acyltransferase	3240	3931	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Haptoglobin inhibits lecithin-cholesterol_acyltransferase in human ovarian follicular fluid .
19627602	0	Haptoglobin	0,11	phospholipid_transfer_protein	21,50	Haptoglobin	phospholipid transfer protein	3240	5360	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Haptoglobin inhibits phospholipid_transfer_protein activity in hyperlipidemic human plasma .
1283808	2	Haptoglobin	54,65	transferrin	67,78	Haptoglobin	transferrin	3240	7018	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Haptoglobin , transferrin , alpha-1-feto protein , alpha-1-acid glycoprotein and caeruloplasmin levels .
18052042	0	Harc	39,43	Hsp70	59,64	Harc	Hsp70	55664	3308	Gene	Gene	START_ENTITY|nmod|binding binding|nmod|END_ENTITY	Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat_shock .
25489104	0	Harvey-Ras	110,120	Dual-specificity_phosphatase_5	0,30	Harvey-Ras	Dual-specificity phosphatase 5	15461(Tax:10090)	240672(Tax:10090)	Gene	Gene	inhibiting|dobj|START_ENTITY regulates|advcl|inhibiting regulates|nsubj|END_ENTITY	Dual-specificity_phosphatase_5 regulates nuclear ERK activity and suppresses skin_cancer by inhibiting mutant Harvey-Ras -LRB- HRasQ61L -RRB- - driven SerpinB2 expression .
26521733	0	Has1	37,41	hyaluronan_synthase_1	14,35	Has1	hyaluronan synthase 1	15116(Tax:10090)	15116(Tax:10090)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Deficiency of hyaluronan_synthase_1 -LRB- Has1 -RRB- results in chronic_joint_inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage_damage .
12186949	0	Has2	170,174	hyaluronan_synthase_2	147,168	Has2	hyaluronan synthase 2	3037	3037	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Changed lamellipodial extension , adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan_synthase_2 -LRB- Has2 -RRB- genes .
14561729	0	Hash-2	69,75	PACE4	40,45	Hash-2	PACE4	430	5046	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta : possible role of placenta-specific basic helix-loop-helix transcription factor , human achaete-scute homologue-2 .
26586808	0	Hat1	47,51	CENP-A/CID	59,69	Hat1	CENP-A/CID	43928(Tax:7227)	36495(Tax:7227)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila_melanogaster .
18753131	0	Hat1p	15,20	Kat1p	22,27	Hat1p	Kat1p	856106(Tax:4932)	856106(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Involvement of Hat1p -LRB- Kat1p -RRB- catalytic activity and subcellular localization in telomeric silencing .
17241872	0	Hath1	24,29	glycogen_synthase_kinase_3beta	54,84	Hath1	glycogen synthase kinase 3beta	474	2932	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen_synthase_kinase_3beta in human colon_cancer .
15339924	0	Hax-1	73,78	Galpha13	0,8	Hax-1	Galpha13	23897(Tax:10090)	14674(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1 .
20665473	0	Hax-1	14,19	Grb7	0,4	Hax-1	Grb7	10456	2886	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation .
20665473	0	Hax-1	14,19	Grb7	95,99	Hax-1	Grb7	10456	2886	Gene	Gene	binds|nmod|START_ENTITY binds|dobj|association association|acl:relcl|offers offers|dobj|model model|nmod|regulation regulation|amod|END_ENTITY	Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation .
10760273	0	Hax-1	58,63	PKD2	38,42	Hax-1	PKD2	10456	5311	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The polycystic_kidney_disease protein PKD2 interacts with Hax-1 , a protein associated with the actin cytoskeleton .
26915802	0	Hax-1	24,29	UCP3	0,4	Hax-1	UCP3	23897(Tax:10090)	22229(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion .
26869103	0	Hax1	136,140	Caspase3	115,123	Hax1	Caspase3	10456	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Grb7 and Hax1 may colocalize partially to mitochondria in EGF-treated SKBR3 cells and their interaction can affect Caspase3 cleavage of Hax1 .
21518791	0	Hax1	0,4	RhoA	56,60	Hax1	RhoA	10456	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Hax1 regulates neutrophil adhesion and motility through RhoA .
4080960	0	HbA2	33,37	hemoglobin_A2	18,31	HbA2	hemoglobin A2	3040	3040	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of hemoglobin_A2 -LRB- HbA2 -RRB- by ion exchange resins freely suspended in test tubes -RSB- .
3710821	0	Hb_A2	18,23	Hb_C	43,47	Hb A2	Hb C	3040	85348	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	The estimation of Hb_A2 in the presence of Hb_C or Hb E by reverse phase high performance liquid chromatography .
3710821	0	Hb_C	43,47	Hb_A2	18,23	Hb C	Hb A2	85348	3040	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	The estimation of Hb_A2 in the presence of Hb_C or Hb E by reverse phase high performance liquid chromatography .
18250300	0	Hbo1	33,37	Plk1	9,13	Hbo1	Plk1	11143	5347	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing .
20947765	0	Hbs1	6,10	Dom34	0,5	Hbs1	Dom34	853959(Tax:4932)	855731(Tax:4932)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Dom34 : Hbs1 promotes subunit dissociation and peptidyl-tRNA drop-off to initiate no-go decay .
11504706	0	Hck	79,82	Hsp90	24,29	Hck	Hsp90	3055	3320	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart .
12033791	0	Hck	24,27	Nef	80,83	Hck	Nef	3055	6285	Gene	Gene	kinase|compound|START_ENTITY Interaction|nmod|kinase reveals|nsubj|Interaction reveals|dobj|evolution evolution|nmod|protein protein|compound|END_ENTITY	Interaction with simian Hck tyrosine kinase reveals convergent evolution of the Nef protein from simian and human immunodeficiency viruses despite differential molecular surface usage .
12076760	0	Hck	119,122	Nef	82,85	Hck	Nef	3055	6285	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|system system|nmod|inhibitors inhibitors|nmod|interaction interaction|nmod|END_ENTITY	A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck .
15491611	0	Hck	107,110	Nef	32,35	Hck	Nef	25734(Tax:10116)	156110(Tax:11676)	Gene	Gene	kinase|compound|START_ENTITY recruitment|nmod|kinase essential|nmod|recruitment essential|nsubj|residues residues|nmod|pocket pocket|compound|END_ENTITY	Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase .
15626739	0	Hck	59,62	Nef	6,9	Hck	Nef	3055	6285	Gene	Gene	activation|compound|START_ENTITY signaling|nmod|activation interferes|xcomp|signaling interferes|nsubj|END_ENTITY	HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities .
16849330	0	Hck	51,54	Nef	6,9	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	kinases|dobj|START_ENTITY activates|ccomp|kinases activates|nsubj|END_ENTITY	HIV-1 Nef selectively activates Src family kinases Hck , Lyn , and c-Src through direct SH3 domain interaction .
21365684	0	Hck	25,28	Nef	62,65	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Structure , dynamics , and Hck interaction of full-length HIV-1 Nef .
21567396	0	Hck	94,97	Nef	6,9	Hck	Nef	3055	6285	Gene	Gene	perturbs|nmod|START_ENTITY perturbs|nsubj|END_ENTITY	HIV-1 Nef perturbs the function , structure , and signaling of the Golgi through the Src kinase Hck .
22420777	0	Hck	80,83	Nef	6,9	Hck	Nef	3055	6285	Gene	Gene	kinase|appos|START_ENTITY site|nmod|kinase influences|dobj|site influences|nsubj|interaction interaction|compound|END_ENTITY	HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase , Hck .
25122770	0	Hck	76,79	Nef	101,104	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	Region|nmod|START_ENTITY Interaction|nmod|Region Structures|nsubj|Interaction Structures|dobj|Dimer Dimer|compound|END_ENTITY	Interaction with the Src Homology -LRB- SH3-SH2 -RRB- Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment .
26440750	0	Hck	33,36	Nef	57,60	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor .
26584215	0	Hck	25,28	Nef	144,147	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	kinase|appos|START_ENTITY involved|nsubjpass|kinase involved|nmod|END_ENTITY	Hemopoietic cell kinase -LRB- Hck -RRB- and p21-activated_kinase_2 -LRB- PAK2 -RRB- are involved in the down-regulation of CD1a lipid antigen presentation by HIV-1 Nef in dendritic cells .
7588629	0	Hck	41,44	Nef	110,113	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	domain|nmod|START_ENTITY amino_acid|nmod|domain determines|nsubj|amino_acid determines|dobj|affinity affinity|nmod|protein protein|amod|binding binding|nmod|END_ENTITY	A single amino_acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein .
8599760	0	Hck	132,135	Nef	32,35	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	kinase|compound|START_ENTITY domain|nmod|kinase surface|nmod|domain fold|nmod|surface reveals|dobj|fold reveals|nsubj|structure structure|nmod|END_ENTITY	The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase .
9218412	0	Hck	13,16	Nef	81,84	Hck	Nef	3055	156110(Tax:11676)	Gene	Gene	tyrosine|nsubj|START_ENTITY tyrosine|dobj|activation activation|nmod|protein protein|compound|END_ENTITY	SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1 .
16953222	0	Hck	24,27	Tel-Abl	44,51	Hck	Tel-Abl	15162(Tax:10090)	2120	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The Src tyrosine kinase Hck is required for Tel-Abl - but not for Tel-Jak2-induced cell transformation .
19234535	0	Hck	11,14	WASp	36,40	Hck	WASp	3055	7454	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils .
9790917	0	Hck	29,32	granulocyte_colony-stimulating_factor	49,86	Hck	granulocyte colony-stimulating factor	3055	1440	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	The Src-like tyrosine kinase Hck is activated by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and docks to the activated G-CSF_receptor .
11145649	0	Hcph	48,52	hematopoietic_cell_phosphatase	16,46	Hcph	hematopoietic cell phosphatase	15170(Tax:10090)	15170(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation of the hematopoietic_cell_phosphatase -LRB- Hcph -RRB- gene is associated with resistance to gamma-irradiation-induced apoptosis in Src_homology_protein_tyrosine_phosphatase -LRB- SHP -RRB- -1 - deficient `` motheaten '' mutant mice .
8324828	0	Hcph	104,108	hematopoietic_cell_protein-tyrosine_phosphatase	55,102	Hcph	hematopoietic cell protein-tyrosine phosphatase	15170(Tax:10090)	15170(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations at the murine motheaten locus are within the hematopoietic_cell_protein-tyrosine_phosphatase -LRB- Hcph -RRB- gene .
17521418	0	Hcrtr-2	46,53	TAC1	22,26	Hcrtr-2	TAC1	399545(Tax:9615)	475239(Tax:9615)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of TAC1 , PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain .
17322895	0	Hdac2	0,5	Gsk3_beta	64,73	Hdac2	Gsk3 beta	15182(Tax:10090)	56637(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY	Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3_beta activity .
6497830	0	Hdc-s	19,24	histidine_decarboxylase	43,66	Hdc-s	histidine decarboxylase	15186(Tax:10090)	15186(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	A structural gene -LRB- Hdc-s -RRB- for mouse kidney histidine_decarboxylase .
7959767	0	Hdh	54,57	Add1	87,91	Hdh	Add1	15194(Tax:10090)	11518(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The murine homologues of the Huntington_disease gene -LRB- Hdh -RRB- and the alpha-adducin gene -LRB- Add1 -RRB- map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16 .3 .
20809635	0	Hdj1	79,83	Hsp40	73,78	Hdj1	Hsp40	3337	3337	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70 .
20809635	0	Hdj1	79,83	Hsp70	145,150	Hdj1	Hsp70	3337	3308	Gene	Gene	domain|compound|START_ENTITY structures|nmod|domain revealed|nmod|structures revealed|nmod|octapeptide octapeptide|nmod|END_ENTITY	Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70 .
15862750	0	Hdm2	65,69	Akt	10,13	Hdm2	Akt	4193	207	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|compound|END_ENTITY	Activated Akt expression in breast_cancer : correlation with p53 , Hdm2 and patient outcome .
15788536	0	Hdm2	37,41	Hdmx	19,23	Hdm2	Hdmx	4193	4193	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Hdmx mediates its Hdm2 - and ATM-dependent degradation in response to DNA damage .
19029954	0	Hdm2	0,4	K-Ras	21,26	Hdm2	K-Ras	4193	3845	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic_cancer cells .
16751805	0	Hdm2	19,23	Nucleolin	0,9	Hdm2	Nucleolin	4193	4691	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization .
18317451	0	Hdm2	99,103	TRAIL	62,67	Hdm2	TRAIL	4193	8743	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Protein_kinase_C_epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53 .
16702947	0	Hdm2	21,25	c-Abl	0,5	Hdm2	c-Abl	4193	25	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF .
22103682	0	Hdm2	44,48	nucleolin	20,29	Hdm2	nucleolin	4193	4691	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|domains domains|nmod|END_ENTITY	Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination .
10077639	0	Hdm2	43,47	p53	93,96	Hdm2	p53	4193	7157	Gene	Gene	shuttling|nmod|START_ENTITY required|nsubjpass|shuttling required|nmod|degradation degradation|nmod|END_ENTITY	Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53 .
11562347	0	Hdm2	99,103	p53	65,68	Hdm2	p53	4193	7157	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|interaction interaction|nmod|glucocorticoid_receptor glucocorticoid_receptor|nmod|END_ENTITY	Ligand-dependent interaction of the glucocorticoid_receptor with p53 enhances their degradation by Hdm2 .
11744695	0	Hdm2	37,41	p53	83,86	Hdm2	p53	4193	7157	Gene	Gene	nucleus|nmod|START_ENTITY recruitment|nmod|nucleus essential|nsubj|recruitment essential|nmod|ability ability|acl|regulate regulate|dobj|stability stability|compound|END_ENTITY	Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation .
16227590	0	Hdm2	87,91	p53	41,44	Hdm2	p53	4193	7157	Gene	Gene	actions|nmod|START_ENTITY accelerates|nmod|actions accelerates|dobj|degradation degradation|compound|END_ENTITY	Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen_synthase_kinase_3beta .
16432175	0	Hdm2	38,42	p53	43,46	Hdm2	p53	4193	7157	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|dep|proliferation proliferation|compound|END_ENTITY	Benzodiazepinedione inhibitors of the Hdm2 : p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo .
16751805	0	Hdm2	19,23	p53	56,59	Hdm2	p53	4193	7157	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nmod|pathways pathways|acl|leading leading|nmod|stabilization stabilization|compound|END_ENTITY	Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization .
16965791	0	Hdm2	26,30	p53	84,87	Hdm2	p53	4193	7157	Gene	Gene	RING|compound|START_ENTITY structure|nmod|RING structure|amod|critical critical|nmod|ubiquitination ubiquitination|nmod|END_ENTITY	Solution structure of the Hdm2 C2H2C4 RING , a domain critical for ubiquitination of p53 .
18723490	0	Hdm2	71,75	p53	33,36	Hdm2	p53	4193	7157	Gene	Gene	inhibitor|nmod|START_ENTITY expressing|nmod|inhibitor expressing|dobj|END_ENTITY	Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2 .
19920202	0	Hdm2	73,77	p53	56,59	Hdm2	p53	4193	7157	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Suppression of hypoxia-inducible_factor_2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal_carcinoma cells .
20124454	8	Hdm2	1722,1726	p53	1644,1647	KRAS	p21	3845	644914	Gene	Gene	expression|amod|START_ENTITY increased|dobj|expression increased|nsubj|END_ENTITY	Transduction of KRAS -LRB- aMut -RRB- / p53 -LRB- wild -RRB- HCT116 , LoVo , and LS174T cells by Ad-KRhdm2 significantly increased Hdm2 expression , decreased p53 level , and abolished the p53-transactivating p21 -LRB- Cip1 -RRB- promoter activity .
14507994	0	HdmX	0,4	p53	64,67	HdmX	p53	4193	7157	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 .
19153082	0	HdmX	34,38	p53	56,59	HdmX	p53	4193	7157	Gene	Gene	Structures|appos|START_ENTITY Structures|nmod|Complex Complex|nmod|Changes Changes|nummod|END_ENTITY	Crystal Structures of Human MdmX -LRB- HdmX -RRB- in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes .
19946469	0	HdmX	77,81	p53	141,144	HdmX	p53	4193	7157	Gene	Gene	stress|nmod|START_ENTITY expression|nmod|stress Alterations|nmod|expression knockdown|nsubj|Alterations knockdown|nmod|cells cells|acl|harboring harboring|dobj|END_ENTITY	Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 .
15788536	0	Hdmx	19,23	Hdm2	37,41	Hdmx	Hdm2	4193	4193	Gene	Gene	Phosphorylation|nmod|START_ENTITY mediates|nsubj|Phosphorylation mediates|dobj|END_ENTITY	Phosphorylation of Hdmx mediates its Hdm2 - and ATM-dependent degradation in response to DNA damage .
10827196	0	Hdmx	0,4	Mdm2	16,20	Hdmx	Mdm2	4193	4193	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Hdmx stabilizes Mdm2 and p53 .
19075013	0	Hdmx	21,25	c-Abl	0,5	Hdmx	c-Abl	4193	25	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Abl phosphorylates Hdmx and regulates its interaction with p53 .
11494153	0	Hdmx	0,4	p53	54,57	Hdmx	p53	4193	7157	Gene	Gene	repress|nsubj|START_ENTITY repress|nmod|END_ENTITY	Hdmx and Mdm2 can repress transcription activation by p53 but not by p63 .
11744695	0	Hdmx	0,4	p53	83,86	Hdmx	p53	4193	7157	Gene	Gene	recruitment|compound|START_ENTITY essential|nsubj|recruitment essential|nmod|ability ability|acl|regulate regulate|dobj|stability stability|compound|END_ENTITY	Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation .
16905769	0	Hdmx	0,4	p53	30,33	Hdmx	p53	4193	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|outcome outcome|nmod|activation activation|compound|END_ENTITY	Hdmx modulates the outcome of p53 activation in human tumor cells .
17640893	0	Hdmx	57,61	p53	78,81	Hdmx	p53	4193	7157	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|activation activation|compound|END_ENTITY	Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation .
10702794	0	HePTP	80,85	ERK2	15,19	HePTP	ERK2	5786	5594	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP .
14613483	0	HePTP	45,50	Haematopoietic_protein_tyrosine_phosphatase	0,43	HePTP	Haematopoietic protein tyrosine phosphatase	5786	5786	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Haematopoietic_protein_tyrosine_phosphatase -LRB- HePTP -RRB- phosphorylation by cAMP-dependent protein kinase in T-cells : dynamics and subcellular location .
8084610	0	HePTP	31,36	LC-PTP	23,29	HePTP	LC-PTP	5778	5778	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the human LC-PTP -LRB- HePTP -RRB- gene : similarity in genomic organization within protein-tyrosine phosphatase genes .
16226275	0	HePTP	53,58	hematopoietic_tyrosine_phosphatase	17,51	HePTP	hematopoietic tyrosine phosphatase	5778	5778	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Structure of the hematopoietic_tyrosine_phosphatase -LRB- HePTP -RRB- catalytic domain : structure of a KIM phosphatase with phosphate bound at the active site .
8957000	0	Heartless	0,9	FGF_receptor	24,36	Heartless	FGF receptor	42160(Tax:7227)	42160(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Heartless , a Drosophila FGF_receptor homolog , is essential for cell migration and establishment of several mesodermal lineages .
16050811	0	Heat-shock_cognate_70	0,21	heat-shock_factor_1	56,75	Heat-shock cognate 70	heat-shock factor 1	3312	3297	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Heat-shock_cognate_70 is required for the activation of heat-shock_factor_1 in mammalian cells .
18840778	0	Heat-shock_protein_70	0,21	Hsp70	23,28	Heat-shock protein 70	Hsp70	3308	3308	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Heat-shock_protein_70 -LRB- Hsp70 -RRB- expression in four limpets of the genus Lottia : interspecific variation in constitutive and inducible synthesis correlates with in situ exposure to heat stress .
19914824	0	Heat-shock_protein_70-2	0,23	HSP70-2	25,32	Heat-shock protein 70-2	HSP70-2	3306	3306	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Heat-shock_protein_70-2 -LRB- HSP70-2 -RRB- expression in bladder urothelial_carcinoma is associated with tumour progression and promotes migration and invasion .
12489981	0	Heat-shock_protein_90	0,21	LKB1	46,50	Heat-shock protein 90	LKB1	3320	6794	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Heat-shock_protein_90 and Cdc37 interact with LKB1 and regulate its stability .
26157141	0	Heat_Shock_Factor_1	104,123	Claudin-1	46,55	Heat Shock Factor 1	Claudin-1	3297	9076	Gene	Gene	Activation|compound|START_ENTITY Expression|nmod|Activation Expression|compound|END_ENTITY	Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat_Shock_Factor_1 Activation , Leading to Hepatoma Cell Invasiveness .
26504030	0	Heat_Shock_Factor_1	49,68	HSP27	97,102	Heat Shock Factor 1	HSP27	3297	3315	Gene	Gene	START_ENTITY|appos|Factor Factor|nmod|END_ENTITY	Active Hexose-correlated Compound Down-regulates Heat_Shock_Factor_1 , a Transcription Factor for HSP27 , in Gemcitabine-resistant Human Pancreatic_Cancer Cells .
24465598	0	Heat_Shock_Factor_1	36,55	HYPK	28,32	Heat Shock Factor 1	HYPK	3297	25764	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcription regulation of HYPK by Heat_Shock_Factor_1 .
26805817	0	Heat_Shock_Protein_27	44,65	HSPB1	67,72	Heat Shock Protein 27	HSPB1	3315	3315	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	The Clinical Significance of Phosphorylated Heat_Shock_Protein_27 -LRB- HSPB1 -RRB- in Pancreatic_Cancer .
26452441	0	Heat_Shock_Protein_60	29,50	CD25	63,67	Heat Shock Protein 60	CD25	15510(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intranasal Immunization with Heat_Shock_Protein_60 Induces CD4 + CD25 + GARP + and Type-1 Regulatory T Cells and Inhibits Early Atherosclerosis .
26452441	0	Heat_Shock_Protein_60	29,50	CD4	59,62	Heat Shock Protein 60	CD4	15510(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Intranasal Immunization with Heat_Shock_Protein_60 Induces CD4 + CD25 + GARP + and Type-1 Regulatory T Cells and Inhibits Early Atherosclerosis .
23840630	0	Heat_Shock_Protein_60	18,39	Neutral_Sphingomyelinase_2	58,84	Heat Shock Protein 60	Neutral Sphingomyelinase 2	3329	55512	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Heat_Shock_Protein_60 as a Regulator of Neutral_Sphingomyelinase_2 and Its Role in Dopamine Uptake .
24312699	0	Heat_Shock_Protein_70	26,47	Hsp70	49,54	Heat Shock Protein 70	Hsp70	3308	3308	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|END_ENTITY	Analogs of the Allosteric Heat_Shock_Protein_70 -LRB- Hsp70 -RRB- Inhibitor , MKT-077 , as Anti-Cancer Agents .
25141341	0	Heat_Shock_Protein_90	45,66	Hsp90	68,73	Heat Shock Protein 90	Hsp90	3320	3320	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Progress in the Discovery and Development of Heat_Shock_Protein_90 -LRB- Hsp90 -RRB- Inhibitors .
22743058	0	Heat_shock_cognate_70	0,21	nucleolin	77,86	Heat shock cognate 70	nucleolin	3312	4691	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	Heat_shock_cognate_70 regulates the translocation and angiogenic function of nucleolin .
20018937	0	Heat_shock_cognate_protein_70	0,29	Akt	47,50	Heat shock cognate protein 70	Akt	3312	207	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Heat_shock_cognate_protein_70 is essential for Akt signaling in endothelial function .
14766217	0	Heat_shock_factor	0,17	VDUP1	28,33	Heat shock factor	VDUP1	3569	10628	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Heat_shock_factor regulates VDUP1 gene expression .
22427437	0	Heat_shock_factor_1	0,19	TRPV1	52,57	Heat shock factor 1	TRPV1	79245(Tax:10116)	83810(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Heat_shock_factor_1 regulates the expression of the TRPV1 gene in the rat preoptic-anterior hypothalamus area during lipopolysaccharide-induced fever .
25280995	0	Heat_shock_factor_1	0,19	hsa-miR-432	30,41	Heat shock factor 1	hsa-miR-432	3297	574451	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Heat_shock_factor_1 regulates hsa-miR-432 expression in human cervical_cancer cell line .
7722915	0	Heat_shock_protein	0,18	oral_lichen_planus	33,51	Heat shock protein	heat shock protein	7190	7190	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Heat_shock_protein expression in oral_lichen_planus .
26443497	0	Heat_shock_protein_20	0,21	protein_kinase_D1	55,72	Heat shock protein 20	protein kinase D1	126393	5587	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Heat_shock_protein_20 -LRB- HSP20 -RRB- is a novel substrate for protein_kinase_D1 -LRB- PKD1 -RRB- .
23311135	0	Heat_shock_protein_27	1,22	NS1	75,78	Heat shock protein 27	NS1	3315	10625	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	-LSB- Heat_shock_protein_27 enhances the inhibitory effect of influenza_A_virus NS1 on the expression of interferon-beta -RSB- .
19597476	0	Heat_shock_protein_27	0,21	SUMO-2	37,43	Heat shock protein 27	SUMO-2	3315	6613	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Heat_shock_protein_27 is involved in SUMO-2 / 3 modification of heat_shock factor 1 and thereby modulates the transcription factor activity .
26137108	0	Heat_shock_protein_27	0,21	activator_protein-1	58,77	Heat shock protein 27	activator protein-1	15507(Tax:10090)	16476(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Heat_shock_protein_27 promotes cell proliferation through activator_protein-1 in lung_cancer .
19767773	0	Heat_shock_protein_27	0,21	protein_kinase_D1	75,92	Heat shock protein 27	protein kinase D1	3315	5587	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Heat_shock_protein_27 mediates repression of androgen_receptor function by protein_kinase_D1 in prostate_cancer cells .
24038883	0	Heat_shock_protein_32	0,21	heme_oxygenase-1	22,38	Heat shock protein 32	heme oxygenase-1	15368(Tax:10090)	15368(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|protects protects|nsubj|END_ENTITY	Heat_shock_protein_32 / heme_oxygenase-1 protects mouse Sertoli cells from hyperthermia-induced apoptosis by CO activation of sGC signalling pathways .
15972659	0	Heat_shock_protein_60	0,21	suppressor_of_cytokine_signaling_3	71,105	Heat shock protein 60	suppressor of cytokine signaling 3	15510(Tax:10090)	12702(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Heat_shock_protein_60 activates cytokine-associated negative regulator suppressor_of_cytokine_signaling_3 in T cells : effects on signaling , chemotaxis , and inflammation .
8683139	0	Heat_shock_protein_65	0,21	CD62e	30,35	Heat shock protein 65	CD62e	3329	6401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Heat_shock_protein_65 induces CD62e , CD106 , and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes .
23913168	0	Heat_shock_protein_70	0,21	HSP70	23,28	Heat shock protein 70	HSP70	3308	3308	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Heat_shock_protein_70 -LRB- HSP70 -RRB- expression is associated with poor prognosis in intestinal_type_gastric_cancer .
12738667	0	Heat_shock_protein_70	0,21	caspase-activated_DNase	28,51	Heat shock protein 70	caspase-activated DNase	3308	1677	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Heat_shock_protein_70 binds caspase-activated_DNase and enhances its activity in TCR-stimulated T cells .
22386689	0	Heat_shock_protein_72	0,21	c-Jun_N-terminal_kinase_3	31,56	Heat shock protein 72	c-Jun N-terminal kinase 3	24472(Tax:10116)	25272(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Heat_shock_protein_72 inhibits c-Jun_N-terminal_kinase_3 signaling pathway via Akt1 during cerebral_ischemia .
12354745	0	Heat_shock_protein_72	0,21	manganese_superoxide_dismutase	31,61	Heat shock protein 72	manganese superoxide dismutase	3303	6648	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Heat_shock_protein_72 enhances manganese_superoxide_dismutase activity during myocardial_ischemia-reperfusion_injury , associated with mitochondrial protection and apoptosis reduction .
23261432	0	Heat_shock_protein_90	0,21	HSP90	23,28	Heat shock protein 90	HSP90	104434(Tax:10090)	104434(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Heat_shock_protein_90 -LRB- HSP90 -RRB- inhibitors activate the heat_shock factor 1 -LRB- HSF1 -RRB- stress response pathway and improve glucose regulation in diabetic mice .
15754027	0	Heat_shock_protein_90	0,21	activator_protein-1	72,91	Heat shock protein 90	activator protein-1	104434(Tax:10090)	16476(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	Heat_shock_protein_90 is required for increased DNA binding activity of activator_protein-1 , a heterodimer of Fos/JunD , in rheumatoid synovial cells under inflammatory stimuli .
21998300	0	Heat_shock_protein_90	0,21	nucleolin	33,42	Heat shock protein 90	nucleolin	3320	4691	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	Heat_shock_protein_90 stabilizes nucleolin to increase mRNA stability in mitosis .
20138989	0	Heat_shock_protein_90	0,21	vitamin_D_receptor	37,55	Heat shock protein 90	vitamin D receptor	3320	7421	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Heat_shock_protein_90 interacts with vitamin_D_receptor in human leukemia cells .
20018623	0	Heat_shock_transcription_factor_1	0,33	IL-6	57,61	Heat shock transcription factor 1	IL-6	15499(Tax:10090)	16193(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Heat_shock_transcription_factor_1 inhibits expression of IL-6 through activating transcription factor 3 .
21056971	0	Hec1	23,27	CENP-U	0,6	Hec1	CENP-U	10403	79682	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	CENP-U cooperates with Hec1 to orchestrate kinetochore-microtubule attachment .
12386167	0	Hec1	49,53	Nek2	57,61	Hec1	Nek2	10403	4751	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation .
16732327	0	Hec1	0,4	Zwint-1	27,34	Hec1	Zwint-1	10403	11130	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control .
20948316	0	Hec1	38,42	pRb	118,121	Hec1	pRb	10403	5925	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway .
16269333	0	HectH9	21,27	Myc	68,71	HectH9	Myc	10075	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation .
22431752	0	Hectd1	0,6	Hsp90	61,66	Hectd1	Hsp90	207304(Tax:10090)	111058(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme .
15708564	0	Hedgehog	32,40	Cad99C	9,15	Hedgehog	Cad99C	42737(Tax:7227)	43528(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cadherin Cad99C is regulated by Hedgehog signaling in Drosophila .
14602684	0	Hedgehog	40,48	Dally-like	13,23	Hedgehog	Dally-like	42737(Tax:7227)	39596(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The glypican Dally-like is required for Hedgehog signalling in the embryonic_epidermis of Drosophila .
22096079	0	Hedgehog	72,80	G-protein-coupled_receptor_kinase_2	11,46	Hedgehog	G-protein-coupled receptor kinase 2	42737(Tax:7227)	49045(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila G-protein-coupled_receptor_kinase_2 regulates cAMP-dependent Hedgehog signaling .
21044292	0	Hedgehog	31,39	Ihog	0,4	Hedgehog	Ihog	42737(Tax:7227)	33972(Tax:7227)	Gene	Gene	essential|advcl|START_ENTITY essential|nsubj|END_ENTITY	Ihog and Boi are essential for Hedgehog signaling in Drosophila .
23154411	0	Hedgehog	67,75	Ihog	131,135	Hedgehog	Ihog	42737(Tax:7227)	33972(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi .
19088085	0	Hedgehog	22,30	PP4	0,3	Hedgehog	PP4	42737(Tax:7227)	31979(Tax:7227)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation .
14597576	0	Hedgehog	31,39	Patched	20,27	Hedgehog	Patched	42737(Tax:7227)	35851(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal , the Drosophila sex determination master switch .
18198278	0	Hedgehog	25,33	Patched	0,7	Hedgehog	Patched	42737(Tax:7227)	35851(Tax:7227)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Patched , the receptor of Hedgehog , is a lipoprotein receptor .
10557210	0	Hedgehog	29,37	Protein_kinase_A	0,16	Hedgehog	Protein kinase A	42737(Tax:7227)	34284(Tax:7227)	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Protein_kinase_A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus .
19055941	0	Hedgehog	54,62	SUFU	46,50	Hedgehog	SUFU	42737(Tax:7227)	51684	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Role and regulation of human tumor suppressor SUFU in Hedgehog signaling .
12874118	0	Hedgehog	22,30	Smoothened	0,10	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	levels|compound|START_ENTITY translates|dobj|levels translates|nsubj|END_ENTITY	Smoothened translates Hedgehog levels into distinct responses .
15592457	0	Hedgehog	58,66	Smoothened	11,21	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	essential|advcl|START_ENTITY phosphorylation|xcomp|essential phosphorylation|nsubj|END_ENTITY	Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction .
15598741	0	Hedgehog	43,51	Smoothened	29,39	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	activation|compound|START_ENTITY phosphorylation|nmod|activation phosphorylation|nmod|END_ENTITY	Extensive phosphorylation of Smoothened in Hedgehog pathway activation .
15616566	0	Hedgehog	0,8	Smoothened	32,42	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Hedgehog signalling activity of Smoothened requires phosphorylation by protein_kinase_A and casein_kinase_I .
18987629	0	Hedgehog	68,76	Smoothened	54,64	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	signalling|compound|START_ENTITY downstream|nmod|signalling downstream|nmod|END_ENTITY	G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling .
23385085	0	Hedgehog	40,48	Smoothened	74,84	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|suppressing suppressing|dobj|END_ENTITY	Drosophila miR-960 negatively regulates Hedgehog signaling by suppressing Smoothened , Costal-2 and Fused .
24985345	0	Hedgehog	0,8	Smoothened	66,76	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|promote promote|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation .
26973699	0	Hedgehog	37,45	Smoothened	0,10	Hedgehog	Smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	stimulation|compound|START_ENTITY regulation|nmod|stimulation regulation|amod|END_ENTITY	Smoothened regulation in response to Hedgehog stimulation .
19684112	0	Hedgehog	65,73	Sufu	57,61	Hedgehog	Sufu	42737(Tax:7227)	41565(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved .
23843610	0	Hedgehog	46,54	Vps36	11,16	Hedgehog	Vps36	42737(Tax:7227)	39523(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|nsubj|END_ENTITY	Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling .
18539010	0	Hedgehog	0,8	furrow	82,88	Hedgehog	furrow	42737(Tax:7227)	44654	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Hedgehog and Dpp signaling induce cadherin_Cad86C expression in the morphogenetic furrow during Drosophila eye development .
16630821	0	Hedgehog	36,44	ihog	4,8	Hedgehog	ihog	42737(Tax:7227)	33972(Tax:7227)	Gene	Gene	bind|acl|START_ENTITY bind|amod|END_ENTITY	The ihog cell-surface proteins bind Hedgehog and mediate pathway activation .
23385085	0	Hedgehog	40,48	miR-960	11,18	Hedgehog	miR-960	42737(Tax:7227)	12798564	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila miR-960 negatively regulates Hedgehog signaling by suppressing Smoothened , Costal-2 and Fused .
17960137	0	Hedgehog	0,8	smoothened	19,29	Hedgehog	smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Hedgehog regulates smoothened activity by inducing a conformational switch .
26495986	0	Helios	35,41	CD4	122,125	Helios	CD4	22779(Tax:10090)	12504(Tax:10090)	Gene	Gene	Level|nmod|START_ENTITY Differences|nmod|Level Do|nsubj|Differences Do|dobj|Thymus-Derived Thymus-Derived|nmod|Cells Cells|compound|END_ENTITY	Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4 + Foxp3 + Regulatory T Cells .
23359504	0	Helios	0,6	FOXP3	53,58	Helios	FOXP3	22807	50943	Gene	Gene	+|compound|START_ENTITY +|dep|cells cells|acl|coexist coexist|nmod|subset subset|compound|END_ENTITY	Helios + and Helios - cells coexist within the natural FOXP3 + T regulatory cell subset in humans .
24068664	0	Helios	13,19	FOXP3	21,26	Helios	FOXP3	22807	50943	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Human memory Helios - FOXP3 + regulatory T cells -LRB- Tregs -RRB- encompass induced Tregs that express Aiolos and respond to IL-1b by downregulating their suppressor functions .
25446972	0	Helios	97,103	FOXP3	109,114	Helios	FOXP3	22807	50943	Gene	Gene	START_ENTITY|appos|Treg Treg|compound|END_ENTITY	Differential expression of the immunosuppressive enzyme IL4I1 induce Aiolos -LRB- + -RRB- , but not natural Helios -LRB- + -RRB- , FOXP3 -LRB- + -RRB- Treg cells .
21570917	0	Helios	87,93	FoxP3	26,31	Helios	FoxP3	22807	50943	Gene	Gene	cells|nmod|START_ENTITY T|dobj|cells T|nsubj|subpopulation subpopulation|nmod|+ +|amod|END_ENTITY	Expanded subpopulation of FoxP3 + T regulatory cells in renal_cell_carcinoma co-express Helios , indicating they could be derived from natural but not induced Tregs .
22827571	0	Helios	0,6	FoxP3	21,26	Helios	FoxP3	22807	50943	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Helios expression in FoxP3 -LRB- + -RRB- T regulatory cells .
23925905	0	Helios	24,30	FoxP3	18,23	Helios	FoxP3	22807	50943	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	The percentage of FoxP3 + Helios + Treg cells correlates positively with disease activity in systemic_lupus_erythematosus .
25733061	0	Helios	0,6	FoxP3	55,60	Helios	FoxP3	22779(Tax:10090)	20371(Tax:10090)	Gene	Gene	Enhances|nsubj|START_ENTITY Enhances|nmod|END_ENTITY	Helios Enhances Treg Cell Function in Cooperation With FoxP3 .
26076982	0	Helios	28,34	FoxP3	52,57	Helios	FoxP3	22807	50943	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	IL-1R1 is expressed on both Helios -LRB- + -RRB- and Helios -LRB- - -RRB- FoxP3 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells in the rheumatic_joint .
20181882	0	Helios	14,20	Foxp3	124,129	Helios	Foxp3	22807	50943	Gene	Gene	Expression|nmod|START_ENTITY differentiates|nsubj|Expression differentiates|dobj|cells cells|amod|thymic-derived thymic-derived|nmod|T T|compound|END_ENTITY	Expression of Helios , an Ikaros transcription factor family member , differentiates thymic-derived from peripherally induced Foxp3 + T regulatory cells .
21677778	0	Helios	0,6	Foxp3	123,128	Helios	Foxp3	22779(Tax:10090)	20371(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|cells cells|acl|differentiating differentiating|xcomp|helper helper|nmod|vivo vivo|nmod|expression expression|amod|END_ENTITY	Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression .
23264341	0	Helios	7,13	Foxp3	0,5	Helios	Foxp3	22807	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Foxp3 + Helios + regulatory T cells are expanded in active systemic_lupus_erythematosus .
26495986	0	Helios	35,41	Foxp3	126,131	Helios	Foxp3	22779(Tax:10090)	20371(Tax:10090)	Gene	Gene	Level|nmod|START_ENTITY Differences|nmod|Level Do|nsubj|Differences Do|dobj|Thymus-Derived Thymus-Derived|nmod|Cells Cells|compound|END_ENTITY	Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4 + Foxp3 + Regulatory T Cells .
8630073	0	Hematopoietic_cell_phosphatase	0,30	T_cell_receptor_zeta_chain	92,118	Hematopoietic cell phosphatase	T cell receptor zeta chain	5777	919	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Hematopoietic_cell_phosphatase -LRB- HCP -RRB- regulates p56LCK phosphorylation and ZAP-70 binding to T_cell_receptor_zeta_chain .
8630073	0	Hematopoietic_cell_phosphatase	0,30	p56LCK	47,53	Hematopoietic cell phosphatase	p56LCK	5777	3932	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Hematopoietic_cell_phosphatase -LRB- HCP -RRB- regulates p56LCK phosphorylation and ZAP-70 binding to T_cell_receptor_zeta_chain .
10414911	0	Hematopoietic_growth_factor	0,27	G-CSF	93,98	Hematopoietic growth factor	G-CSF	3562	1440	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Hematopoietic_growth_factor after autologous peripheral blood transplantation : comparison of G-CSF and GM-CSF .
19012179	0	Hematopoietic_lineage_cell-specific_protein-1	0,45	ERK	75,78	Hematopoietic lineage cell-specific protein-1	ERK	15163(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Hematopoietic_lineage_cell-specific_protein-1 -LRB- HS1 -RRB- regulates PAR-mediated ERK activation and thromboxane generation in platelets .
19917685	0	Hematopoietic_lineage_cell-specific_protein_1	0,45	IL-2-inducible_T_cell_kinase	91,119	Hematopoietic lineage cell-specific protein 1	IL-2-inducible T cell kinase	3059	3702	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Hematopoietic_lineage_cell-specific_protein_1 is recruited to the immunological synapse by IL-2-inducible_T_cell_kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading .
12522005	0	Hematopoietic_progenitor_kinase_1	0,33	fos	87,90	Hematopoietic progenitor kinase 1	fos	11184	2353	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Hematopoietic_progenitor_kinase_1 -LRB- HPK1 -RRB- negatively regulates prostaglandin_E2-induced fos gene transcription .
11564869	0	Hematopoietic_protein_tyrosine_phosphatase	0,42	extracellular_stimulus-regulated_kinase	54,93	Hematopoietic protein tyrosine phosphatase	extracellular stimulus-regulated kinase	320139(Tax:10090)	26413(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Hematopoietic_protein_tyrosine_phosphatase suppresses extracellular_stimulus-regulated_kinase activation .
21994478	0	Heme_Oxygenase-1	163,179	AMP-activated_Protein_Kinase	123,151	Heme Oxygenase-1	AMP-activated Protein Kinase	3162	5563	Gene	Gene	Species|nmod|START_ENTITY Species|nmod|Activation Activation|nmod|Induced Induced|compound|END_ENTITY	Cilostazol Inhibits Vascular Smooth Muscle Cell Proliferation and Reactive Oxygen Species Production through Activation of AMP-activated_Protein_Kinase Induced by Heme_Oxygenase-1 .
27057372	0	Heme_Oxygenase-1	29,45	Herpud1	12,19	Heme Oxygenase-1	Herpud1	15368(Tax:10090)	64209(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Deletion of Herpud1 Enhances Heme_Oxygenase-1 Expression in a Mouse Model of Parkinson 's _ Disease .
19177192	0	Heme_Oxygenase-1	58,74	Nrf2	94,98	Heme Oxygenase-1	Nrf2	3162	4780	Gene	Gene	Expression|compound|START_ENTITY Induces|dobj|Expression Induces|nmod|Activation Activation|compound|END_ENTITY	Dimethoxycurcumin , a Synthetic Curcumin Analogue , Induces Heme_Oxygenase-1 Expression through Nrf2 Activation in RAW264 .7 Macrophages .
25014792	0	Heme_Oxygenase-1	21,37	Nrf2	121,125	Heme Oxygenase-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	Transfer|nmod|START_ENTITY Transfer|dep|Rescues Rescues|dep|Nuclear_Factor_Erythroid_2-Related_Factor Nuclear_Factor_Erythroid_2-Related_Factor|appos|END_ENTITY	Adoptive Transfer of Heme_Oxygenase-1 -LRB- HO-1 -RRB- - Modified Macrophages Rescues the Nuclear_Factor_Erythroid_2-Related_Factor -LRB- Nrf2 -RRB- Antiinflammatory Phenotype in Liver_Ischemia / Reperfusion Injury .
25107906	0	Heme_Oxygenase-1	8,24	Nrf2	85,89	Heme Oxygenase-1	Nrf2	3162	4780	Gene	Gene	Modulates|nsubj|START_ENTITY Modulates|dobj|Distribution Distribution|nmod|END_ENTITY	Nuclear Heme_Oxygenase-1 -LRB- HO-1 -RRB- Modulates Subcellular Distribution and Activation of Nrf2 , Impacting Metabolic and Anti-oxidant Defenses .
26505893	0	Heme_Oxygenase-1	121,137	Nrf2	91,95	Heme Oxygenase-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	Pathway|nmod|START_ENTITY Pathway|amod|END_ENTITY	Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells : Role of MAPKs on the Nrf2 Pathway and Induction of Heme_Oxygenase-1 .
26730678	0	Heme_Oxygenase-1	63,79	Nrf2	8,12	Heme Oxygenase-1	Nrf2	3162	4780	Gene	Gene	Coordinated|nmod|START_ENTITY Coordinated|compound|END_ENTITY	Diverse Nrf2 Activators Coordinated to Cobalt_Carbonyls Induce Heme_Oxygenase-1 and Release Carbon_Monoxide in Vitro and in Vivo .
17942419	0	Heme_oxygenase-1	0,16	BACH1	90,95	Heme oxygenase-1	BACH1	3162	571	Gene	Gene	induction|amod|START_ENTITY requires|nsubj|induction requires|dobj|inactivation inactivation|nmod|END_ENTITY	Heme_oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1 .
17652371	0	Heme_oxygenase-1	0,16	CXCL-10	75,82	Heme oxygenase-1	CXCL-10	3162	3627	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Heme_oxygenase-1 modulates the expression of the anti-angiogenic chemokine CXCL-10 in renal tubular epithelial cells .
24224047	0	Heme_oxygenase-1	0,16	HO-1	18,22	Heme oxygenase-1	HO-1	3162	3162	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Heme_oxygenase-1 -LRB- HO-1 -RRB- expression in prostate_cancer cells modulates the oxidative response in bone cells .
8738152	0	Heme_oxygenase-1	0,16	HO-1	18,22	Heme oxygenase-1	HO-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Heme_oxygenase-1 -LRB- HO-1 -RRB- protein induction in rat brain following focal ischemia .
23840483	0	Heme_oxygenase-1	0,16	MMP-1	52,57	Heme oxygenase-1	MMP-1	3162	4312	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Heme_oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes .
17942419	0	Heme_oxygenase-1	0,16	NRF2	30,34	Heme oxygenase-1	NRF2	3162	4780	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Heme_oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1 .
10924066	0	Heme_oxygenase-1	0,16	angiotensin_II	90,104	Heme oxygenase-1	angiotensin II	24451(Tax:10116)	24179(Tax:10116)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|administration administration|nmod|END_ENTITY	Heme_oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin_II .
16181103	0	Heme_oxygenase-1	0,16	angiotensin_II	94,108	Heme oxygenase-1	angiotensin II	15368(Tax:10090)	11606(Tax:10090)	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|cardiovascular_damage cardiovascular_damage|acl|induced induced|nmod|END_ENTITY	Heme_oxygenase-1 in vascular smooth muscle cells counteracts cardiovascular_damage induced by angiotensin_II .
18174886	0	Heme_oxygenase-1	0,16	angiotensin_II	67,81	Heme oxygenase-1	angiotensin II	15368(Tax:10090)	11606(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY improve|nsubj|induction improve|nmod|mice mice|amod|END_ENTITY	Heme_oxygenase-1 induction does not improve vascular relaxation in angiotensin_II hypertensive mice .
18515325	0	Heme_oxygenase-1	0,16	angiotensin_II	49,63	Heme oxygenase-1	angiotensin II	3162	183	Gene	Gene	expression|amod|START_ENTITY down-regulated|nsubjpass|expression down-regulated|nmod|END_ENTITY	Heme_oxygenase-1 expression is down-regulated by angiotensin_II and under hypertension in human neutrophils .
9052897	0	Heme_oxygenase-1	0,16	angiotensin_II	33,47	Heme oxygenase-1	angiotensin II	24451(Tax:10116)	24179(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Heme_oxygenase-1 is regulated by angiotensin_II in rat vascular smooth muscle cells .
20470258	0	Heme_oxygenase-1	0,16	cyclooxygenase-2	81,97	Heme oxygenase-1	cyclooxygenase-2	3162	5743	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Heme_oxygenase-1 mediates nicotine - and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in human periodontal ligament cells .
10589693	0	Heme_oxygenase-1	0,16	inducible_nitric_oxide_synthase	38,69	Heme oxygenase-1	inducible nitric oxide synthase	3162	4843	Gene	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Heme_oxygenase-1 induction attenuates inducible_nitric_oxide_synthase expression and proteinuria in glomerulonephritis .
18483307	0	Heme_oxygenase-1	0,16	matrix_metalloproteinase-9	83,109	Heme oxygenase-1	matrix metalloproteinase-9	3162	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|breast_cancer_invasion breast_cancer_invasion|acl|suppressing suppressing|dobj|expression expression|nmod|END_ENTITY	Heme_oxygenase-1 inhibits breast_cancer_invasion via suppressing the expression of matrix_metalloproteinase-9 .
21115498	0	Heme_oxygenase-1	0,16	p38	91,94	Heme oxygenase-1	p38	24451(Tax:10116)	81649(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|induces induces|dobj|expression expression|nmod|activation activation|amod|END_ENTITY	Heme_oxygenase-1 / carbon_monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1 .
19797297	0	Heme_oxygenase_1	17,33	CD4	54,57	Heme oxygenase 1	CD4	3162	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Pivotal Advance : Heme_oxygenase_1 expression by human CD4 + T cells is not sufficient for their development of immunoregulatory capacity .
15240748	0	Heme_oxygenase_1	0,16	IL-10	39,44	Heme oxygenase 1	IL-10	3162	3586	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Heme_oxygenase_1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide .
22231145	0	Heme_oxygenase_1	0,16	cytosolic_phospholipase_A2	51,77	Heme oxygenase 1	cytosolic phospholipase A2	15368(Tax:10090)	18783(Tax:10090)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Heme_oxygenase_1 attenuates interleukin-1b-induced cytosolic_phospholipase_A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator _ protein_1 activation in rheumatoid_arthritis synovial fibroblasts .
21982894	0	Heme_oxygenase_1	0,16	miR-155	31,38	Heme oxygenase 1	miR-155	3162	406947	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Heme_oxygenase_1 is induced by miR-155 via reduced BACH1 translation in endothelial cells .
20393131	0	Hemgn	0,5	HOXB4	44,49	Hemgn	HOXB4	93966(Tax:10090)	15412(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells .
18521456	0	Hemochromatosis	0,15	HFE	22,25	Hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hemochromatosis gene -LRB- HFE -RRB- mutations in patients with type 2 diabetes and their control group in an Iranian population .
15916057	0	Hemoglobin_E	0,12	hemoglobin_E	47,59	Hemoglobin E	hemoglobin E	3046	3046	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Hemoglobin_E levels in double heterozygotes of hemoglobin_E and SEA-type_alpha-thalassemia .
26156403	0	Hen2	31,35	Lmo3	10,14	Hen2	Lmo3	18072(Tax:10090)	109593(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice .
2566971	0	Hep	24,27	GLUT	64,68	Hep	GLUT	728489	6513	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Stu I RFLP at the human Hep G2/erythrocyte glucose transporter -LRB- GLUT -RRB- gene locus .
10026256	0	Heparan_sulfate_proteoglycan	0,28	keratinocyte_growth_factor	39,65	Heparan sulfate proteoglycan	keratinocyte growth factor	100689041	100761599	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Heparan_sulfate_proteoglycan modulates keratinocyte_growth_factor signaling through interaction with both ligand and receptor .
22715311	0	Heparanase	27,37	HPSE	39,43	Heparanase	HPSE	10855	10855	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A Phylogenetic analysis of Heparanase -LRB- HPSE -RRB- gene .
26893739	0	Heparanase	0,10	VEGF-C	30,36	Heparanase	VEGF-C	10855	7424	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic_ductal_cell_adenocarcinoma .
18798279	0	Heparanase	0,10	VEGF_C	19,25	Heparanase	VEGF C	10855	7424	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Heparanase induces VEGF_C and facilitates tumor lymphangiogenesis .
24465803	0	Heparanase	0,10	resistin	26,34	Heparanase	resistin	10855	56729	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Heparanase interacts with resistin and augments its activity .
18217145	0	Heparanase	0,10	tissue_factor_pathway_inhibitor	19,50	Heparanase	tissue factor pathway inhibitor	10855	7035	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Heparanase induces tissue_factor_pathway_inhibitor expression and extracellular accumulation in endothelial and tumor cells .
25779761	0	Heparin-Binding_EGF-Like_Growth_Factor	14,52	HB-EGF	54,60	Heparin-Binding EGF-Like Growth Factor	HB-EGF	522921(Tax:9913)	522921(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Heparin-Binding_EGF-Like_Growth_Factor -LRB- HB-EGF -RRB- in Bovine Endometrium : Effects of HB-EGF and Interferon - on Prostaglandin Production .
12882762	0	Heparin-binding_EGF-like_growth_factor	0,38	elastin	49,56	Heparin-binding EGF-like growth factor	elastin	25433(Tax:10116)	25043(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Heparin-binding_EGF-like_growth_factor regulates elastin and FGF-2 expression in pulmonary fibroblasts .
15380451	0	Heparin-binding_EGF-like_growth_factor	0,38	lectin-like_oxidized_LDL_receptor-1	61,96	Heparin-binding EGF-like growth factor	lectin-like oxidized LDL receptor-1	522921(Tax:9913)	281368(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Heparin-binding_EGF-like_growth_factor induces expression of lectin-like_oxidized_LDL_receptor-1 in vascular smooth muscle cells .
8756003	0	Heparin-binding_epidermal_growth_factor-like_growth_factor	0,58	fibroblast_growth_factor-2	69,95	Heparin-binding epidermal growth factor-like growth factor	fibroblast growth factor-2	1839	2247	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Heparin-binding_epidermal_growth_factor-like_growth_factor regulates fibroblast_growth_factor-2 expression in aortic smooth_muscle_cells .
16940294	0	Heparin_affin_regulatory_peptide	0,32	pleiotrophin	33,45	Heparin affin regulatory peptide	pleiotrophin	5764	5764	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Heparin_affin_regulatory_peptide / pleiotrophin mediates fibroblast_growth_factor_2 stimulatory effects on human prostate_cancer cells .
15001987	0	Heparin_affin_regulatory_peptide	0,32	vascular_endothelial_growth_factor	42,76	Heparin affin regulatory peptide	vascular endothelial growth factor	5764	7422	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Heparin_affin_regulatory_peptide binds to vascular_endothelial_growth_factor -LRB- VEGF -RRB- and inhibits VEGF-induced angiogenesis .
10349131	0	Heparin_cofactor_II	1,20	thrombin	24,32	Heparin Cofactor II	thrombin	3053	2147	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	-LSB- Heparin_cofactor_II , a thrombin inhibitor with a still not clarified physiologic role -RSB- .
1896960	0	Heparin_cofactor_II	0,19	thrombin	55,63	Heparin cofactor II	thrombin	100009170(Tax:9986)	2147	Gene	Gene	significance|nsubj|START_ENTITY significance|nmod|inhibition inhibition|nmod|END_ENTITY	Heparin_cofactor_II significance for the inhibition of thrombin at the injured vessel wall .
22190905	0	Hepatic_Nuclear_Factor_4a	41,66	Scavenger_Receptor_BI	16,37	Hepatic Nuclear Factor 4a	Scavenger Receptor BI	25735(Tax:10116)	25073(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of Scavenger_Receptor_BI by Hepatic_Nuclear_Factor_4a through a Peroxisome Proliferator-Activated Receptor y-Dependent Mechanism in Liver .
25550127	0	Hepatic_lipase	0,14	LIPC	16,20	Hepatic lipase	LIPC	3990	3990	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Hepatic_lipase -LRB- LIPC -RRB- C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty_liver in Mexican population .
1900192	0	Hepatic_lipase	0,14	apolipoprotein_A-I	34,52	Hepatic lipase	apolipoprotein A-I	3990	335	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|loss loss|nmod|END_ENTITY	Hepatic_lipase promotes a loss of apolipoprotein_A-I from triglyceride-enriched human high density lipoproteins during incubation in vitro .
8468529	0	Hepatic_lipase	0,14	apolipoprotein_E	71,87	Hepatic lipase	apolipoprotein E	24538(Tax:10116)	25728(Tax:10116)	Gene	Gene	treatment|amod|START_ENTITY increases|nsubj|treatment increases|dobj|exposure exposure|nmod|END_ENTITY	Hepatic_lipase treatment of chylomicron remnants increases exposure of apolipoprotein_E .
15123725	0	Hepatic_nuclear_factor_3	0,24	5-aminolevulinate_synthase	55,81	Hepatic nuclear factor 3	5-aminolevulinate synthase	2305	211	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Hepatic_nuclear_factor_3 and nuclear factor 1 regulate 5-aminolevulinate_synthase gene expression and are involved in insulin repression .
23628799	0	Hepatic_nuclear_factor_4a	0,25	complement_C3	47,60	Hepatic nuclear factor 4a	complement C3	3172	718	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Hepatic_nuclear_factor_4a positively regulates complement_C3 expression and does not interfere with TNFa-mediated stimulation of C3 expression in HepG2 cells .
26381405	0	Hepatocyte_Growth_Factor	91,115	EGFR	33,37	Hepatocyte Growth Factor	EGFR	3082	1956	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Integrin a6b4 Promotes Autocrine EGFR Signaling to Stimulate Migration and Invasion toward Hepatocyte_Growth_Factor -LRB- HGF -RRB- .
25610321	0	Hepatocyte_Growth_Factor	20,44	HGF	46,49	Hepatocyte Growth Factor	HGF	3082	3082	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association between Hepatocyte_Growth_Factor -LRB- HGF -RRB- Gene Polymorphisms and Serum HGF Levels in Patients with Rheumatoid_Arthritis .
24961196	0	Hepatocyte_Growth_Factor	4,28	c-Met	29,34	Hepatocyte Growth Factor	c-Met	24446(Tax:10116)	24553(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|Blocks Blocks|nsubj|Antagonist Antagonist|amod|END_ENTITY	The Hepatocyte_Growth_Factor / c-Met Antagonist , Divalinal-Angiotensin IV , Blocks the Acquisition of Methamphetamine Dependent Conditioned Place Preference in Rats .
25840981	0	Hepatocyte_Growth_Factor	41,65	c-Met	7,12	Hepatocyte Growth Factor	c-Met	3082	4233	Gene	Gene	PET|nmod|START_ENTITY PET|nmod|END_ENTITY	PET of c-Met in cancer with 64Cu-labeled Hepatocyte_Growth_Factor .
25840981	0	Hepatocyte_Growth_Factor	41,65	c-Met	7,12	Hepatocyte Growth Factor	c-Met	3082	4233	Gene	Gene	PET|nmod|START_ENTITY PET|nmod|END_ENTITY	PET of c-Met in cancer with 64Cu-labeled Hepatocyte_Growth_Factor .
26930610	0	Hepatocyte_Nuclear_Factor_3b	51,79	CYP2B6	30,36	Hepatocyte Nuclear Factor 3b	CYP2B6	3170	1555	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Transcriptional Regulation of CYP2B6 Expression by Hepatocyte_Nuclear_Factor_3b in Human Liver Cells .
27075303	0	Hepatocyte_Nuclear_Factor_4a	35,63	Carboxylesterase_1	0,18	Hepatocyte Nuclear Factor 4a	Carboxylesterase 1	3172	1066	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|END_ENTITY	Carboxylesterase_1 Is Regulated by Hepatocyte_Nuclear_Factor_4a and Protects Against Alcohol - and MCD diet-induced Liver_Injury .
21932108	0	Hepatocyte_growth_factor	0,24	AKT	114,117	Hepatocyte growth factor	AKT	3082	207	Gene	Gene	relative|nsubj|START_ENTITY relative|xcomp|END_ENTITY	Hepatocyte_growth_factor promoting the proliferation of human eccrine sweat gland epithelial cells is relative to AKT signal channel and b-catenin .
11003625	0	Hepatocyte_growth_factor	0,24	Akt	115,118	Hepatocyte growth factor	Akt	3082	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|death death|nmod|cells cells|nmod|activation activation|compound|END_ENTITY	Hepatocyte_growth_factor promotes cell survival from fas-mediated cell death in hepatocellular_carcinoma cells via Akt activation and Fas-death-inducing signaling complex suppression .
15522281	0	Hepatocyte_growth_factor	0,24	Akt	85,88	Hepatocyte growth factor	Akt	15234(Tax:10090)	11651(Tax:10090)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|nmod|mice mice|nmod|END_ENTITY	Hepatocyte_growth_factor prevents ventricular_remodeling_and_dysfunction in mice via Akt pathway and angiogenesis .
17412827	0	Hepatocyte_growth_factor	0,24	Akt	70,73	Hepatocyte growth factor	Akt	15234(Tax:10090)	11651(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|regeneration regeneration|nmod|signaling signaling|compound|END_ENTITY	Hepatocyte_growth_factor promotes colonic epithelial regeneration via Akt signaling .
18262389	0	Hepatocyte_growth_factor	0,24	Akt	114,117	Hepatocyte growth factor	Akt	3082	207	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|differentiation differentiation|nmod|pathway pathway|compound|END_ENTITY	Hepatocyte_growth_factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway .
21744257	0	Hepatocyte_growth_factor	0,24	Akt	132,135	Hepatocyte growth factor	Akt	15234(Tax:10090)	11651(Tax:10090)	Gene	Gene	upregulation|compound|START_ENTITY promotes|nsubj|upregulation promotes|dobj|carcinogenesis carcinogenesis|nmod|pathways pathways|compound|END_ENTITY	Hepatocyte_growth_factor upregulation promotes carcinogenesis and epithelial-mesenchymal_transition_in_hepatocellular_carcinoma via Akt and COX-2 pathways .
16899975	0	Hepatocyte_growth_factor	0,24	C-reactive_protein	76,94	Hepatocyte growth factor	C-reactive protein	3082	1401	Gene	Gene	indicator|nsubj|START_ENTITY indicator|nmod|response response|nmod|END_ENTITY	Hepatocyte_growth_factor is a better indicator of therapeutic response than C-reactive_protein within the first day of treatment in pneumonia .
9058297	0	Hepatocyte_growth_factor	0,24	C-reactive_protein	78,96	Hepatocyte growth factor	C-reactive protein	3082	1401	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Hepatocyte_growth_factor in assessment of acute pancreatitis : comparison with C-reactive_protein and interleukin-6 .
18992144	0	Hepatocyte_growth_factor	0,24	DR5	84,87	Hepatocyte growth factor	DR5	3082	8795	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Hepatocyte_growth_factor enhances death receptor-induced apoptosis by up-regulating DR5 .
10836994	0	Hepatocyte_growth_factor	0,24	E1AF	37,41	Hepatocyte growth factor	E1AF	3082	2118	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Hepatocyte_growth_factor upregulates E1AF that induces oral_squamous_cell_carcinoma cell invasion by activating matrix metalloproteinase genes .
22052230	0	Hepatocyte_growth_factor	0,24	EGFR	39,43	Hepatocyte growth factor	EGFR	3082	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|lung_cancer lung_cancer|amod|END_ENTITY	Hepatocyte_growth_factor expression in EGFR mutant lung_cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort .
15277494	0	Hepatocyte_growth_factor	0,24	ERK1/2	94,100	Hepatocyte growth factor	ERK1/2	3082	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Hepatocyte_growth_factor induces proliferation of lens epithelial cells through activation of ERK1/2 and JNK/SAPK .
19526316	0	Hepatocyte_growth_factor	0,24	Egr-1	64,69	Hepatocyte growth factor	Egr-1	3082	1958	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Hepatocyte_growth_factor induced up-regulations of VEGF through Egr-1 in hepatocellular_carcinoma cells .
11164712	0	Hepatocyte_growth_factor	0,24	HGF	26,29	Hepatocyte growth factor	HGF	3082	3082	Gene	Gene	activator|amod|START_ENTITY activator|appos|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation .
12201209	0	Hepatocyte_growth_factor	0,24	HGF	60,63	Hepatocyte growth factor	HGF	3082	3082	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Hepatocyte_growth_factor as cardiovascular hormone : role of HGF in the pathogenesis of cardiovascular_disease .
12613501	0	Hepatocyte_growth_factor	0,24	HGF	26,29	Hepatocyte growth factor	HGF	3082	3082	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- system in gingiva : HGF_activator expression by gingival epithelial cells .
22989111	0	Hepatocyte_growth_factor	0,24	HLX1	35,39	Hepatocyte growth factor	HLX1	3082	3142	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Hepatocyte_growth_factor regulates HLX1 gene expression to modulate HTR-8 / SVneo trophoblast cells .
17464544	0	Hepatocyte_growth_factor	0,24	IL-1beta	34,42	Hepatocyte growth factor	IL-1beta	3082	3553	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Hepatocyte_growth_factor enhances IL-1beta stimulated IL-8 secretion by Caco-2 epithelial cells .
20726333	0	Hepatocyte_growth_factor	0,24	IL-1beta	207,215	Hepatocyte growth factor	IL-1beta	3082	3553	Gene	Gene	heat_shock|nsubj|START_ENTITY heat_shock|nmod|incubation incubation|nmod|camptothecin camptothecin|compound|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- , heat_shock proteins -LRB- HSPs -RRB- and multidrug resistance protein -LRB- MRP -RRB- expression in co-culture of colon_tumor spheroids with normal cells after incubation with interleukin-1beta -LRB- IL-1beta -RRB- and/or camptothecin -LRB- CPT-11 -RRB- .
17022947	0	Hepatocyte_growth_factor	0,24	M-CSF	44,49	Hepatocyte growth factor	M-CSF	3082	1435	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	Hepatocyte_growth_factor can substitute for M-CSF to support osteoclastogenesis .
14999683	0	Hepatocyte_growth_factor	0,24	Mcl-1	33,38	Hepatocyte growth factor	Mcl-1	3082	4170	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Hepatocyte_growth_factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt .
8665484	0	Hepatocyte_growth_factor	0,24	Nck	47,50	Hepatocyte growth factor	Nck	3082	4690	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Hepatocyte_growth_factor induces activation of Nck and phospholipase C-gamma in lung_carcinoma cells .
19393645	0	Hepatocyte_growth_factor	0,24	SHP2	47,51	Hepatocyte growth factor	SHP2	15234(Tax:10090)	19247(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- signals through SHP2 to regulate primary mouse myoblast proliferation .
1280422	0	Hepatocyte_growth_factor	0,24	alpha-fetoprotein	44,61	Hepatocyte growth factor	alpha-fetoprotein	3082	174	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Hepatocyte_growth_factor down-regulates the alpha-fetoprotein gene expression in PLC/PRF/5 human hepatoma cells .
20926686	0	Hepatocyte_growth_factor	0,24	angiotensin_II	70,84	Hepatocyte growth factor	angiotensin II	24446(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Hepatocyte_growth_factor inhibits apoptosis by the profibrotic factor angiotensin_II via extracellular_signal-regulated_kinase_1 / 2 in endothelial cells and tissue explants .
11929826	0	Hepatocyte_growth_factor	0,24	beta-catenin	74,86	Hepatocyte growth factor	beta-catenin	24446(Tax:10116)	84353(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Hepatocyte_growth_factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes .
18245266	0	Hepatocyte_growth_factor	0,24	beta-catenin	67,79	Hepatocyte growth factor	beta-catenin	3082	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Hepatocyte_growth_factor regulates cyclooxygenase-2 expression via beta-catenin , Akt , and p42/p44 _ MAPK in human bronchial epithelial cells .
17203235	0	Hepatocyte_growth_factor	0,24	bone_morphogenetic_protein	60,86	Hepatocyte growth factor	bone morphogenetic protein	15234(Tax:10090)	649	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Hepatocyte_growth_factor up-regulates the expression of the bone_morphogenetic_protein -LRB- BMP -RRB- receptors , BMPR-IB and BMPR-II , in human prostate_cancer cells .
18628208	0	Hepatocyte_growth_factor	0,24	c-MET	25,30	Hepatocyte growth factor	c-MET	3082	4233	Gene	Gene	START_ENTITY|parataxis|unrestricted unrestricted|nsubj|tropism tropism|amod|END_ENTITY	Hepatocyte_growth_factor / c-MET axis-mediated tropism of cord blood-derived unrestricted somatic stem cells for neuronal_injury .
23386689	0	Hepatocyte_growth_factor	0,24	c-MET	52,57	Hepatocyte growth factor	c-MET	3082	4233	Gene	Gene	sensitizes|compound|START_ENTITY brain_tumors|nsubj|sensitizes brain_tumors|xcomp|END_ENTITY	Hepatocyte_growth_factor sensitizes brain_tumors to c-MET kinase inhibition .
11896611	0	Hepatocyte_growth_factor	0,24	c-Met	63,68	Hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|amod|END_ENTITY	Hepatocyte_growth_factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic_mice treated with diethylnitrosamine .
15342394	0	Hepatocyte_growth_factor	0,24	c-Met	25,30	Hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|signaling signaling|amod|END_ENTITY	Hepatocyte_growth_factor / c-Met signaling promotes the progression of experimental human neuroblastomas .
22287599	0	Hepatocyte_growth_factor	0,24	c-Met	25,30	Hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|important important|nsubj|signalling signalling|amod|END_ENTITY	Hepatocyte_growth_factor / c-Met signalling is important for the selection of transplanted hepatocytes .
23209838	0	Hepatocyte_growth_factor	0,24	c-Met	121,126	Hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|pathway pathway|amod|END_ENTITY	Hepatocyte_growth_factor increases vascular_endothelial_growth_factor-A production in human synovial fibroblasts through c-Met receptor pathway .
24089510	0	Hepatocyte_growth_factor	0,24	c-Met	25,30	Hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|signaling signaling|amod|END_ENTITY	Hepatocyte_growth_factor / c-Met signaling is required for b-cell regeneration .
16646560	0	Hepatocyte_growth_factor	0,24	c-met	25,30	Hepatocyte growth factor	c-met	3082	4233	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Hepatocyte_growth_factor / c-met signaling in regulating urokinase plasminogen activator in human stomach_cancer : A potential therapeutic target for human stomach_cancer .
22095660	0	Hepatocyte_growth_factor	0,24	c-met	25,30	Hepatocyte growth factor	c-met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|signaling signaling|amod|END_ENTITY	Hepatocyte_growth_factor / c-met signaling is required for stem-cell-mediated liver regeneration in mice .
26440443	0	Hepatocyte_growth_factor	0,24	c-met	25,30	Hepatocyte growth factor	c-met	100316908(Tax:9986)	100126565(Tax:9986)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Hepatocyte_growth_factor / c-met promotes proliferation , suppresses apoptosis , and improves matrix metabolism in rabbit nucleus pulposus cells in vitro .
9334823	0	Hepatocyte_growth_factor	0,24	c-met	126,131	Hepatocyte growth factor	c-met	3082	4233	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|cells cells|acl|expressing expressing|dobj|levels levels|nmod|END_ENTITY	Hepatocyte_growth_factor stimulates motility , chemotaxis and mitogenesis in ovarian_carcinoma cells expressing high levels of c-met .
9537587	0	Hepatocyte_growth_factor	0,24	c-met	113,118	Hepatocyte growth factor	c-met	3082	4233	Gene	Gene	START_ENTITY|parataxis|stimulates stimulates|nmod|receptor receptor|amod|END_ENTITY	Hepatocyte_growth_factor / scatter factor stimulates chemotaxis and growth of malignant_mesothelioma cells through c-met receptor .
9030587	0	Hepatocyte_growth_factor	0,24	ciliary_neurotrophic_factor	76,103	Hepatocyte growth factor	ciliary neurotrophic factor	24446(Tax:10116)	25707(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Hepatocyte_growth_factor promotes motor neuron survival and synergizes with ciliary_neurotrophic_factor .
11197751	0	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	115,131	Hepatocyte growth factor	cyclooxygenase-2	3082	5743	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|induction induction|nmod|END_ENTITY	Hepatocyte_growth_factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2 .
12393863	0	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	88,104	Hepatocyte growth factor	cyclooxygenase-2	3082	5743	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Hepatocyte_growth_factor inhibits anoikis by induction of activator_protein_1-dependent cyclooxygenase-2 .
16139560	0	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	52,68	Hepatocyte growth factor	cyclooxygenase-2	3082	5743	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|pathway pathway|amod|END_ENTITY	Hepatocyte_growth_factor expression correlates with cyclooxygenase-2 pathway in human salivary_gland_tumors .
18097584	0	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	72,88	Hepatocyte growth factor	cyclooxygenase-2	3082	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	Hepatocyte_growth_factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial_cancer cells .
18245266	0	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	35,51	Hepatocyte growth factor	cyclooxygenase-2	3082	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Hepatocyte_growth_factor regulates cyclooxygenase-2 expression via beta-catenin , Akt , and p42/p44 _ MAPK in human bronchial epithelial cells .
1846541	0	Hepatocyte_growth_factor	0,24	hepatopoietin_A	25,40	Hepatocyte growth factor	hepatopoietin A	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|stimulates stimulates|nsubj|END_ENTITY	Hepatocyte_growth_factor / hepatopoietin_A stimulates the growth of rat kidney proximal tubule epithelial cells -LRB- RPTE -RRB- , rat nonparenchymal liver cells , human melanoma cells , mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE .
19071214	0	Hepatocyte_growth_factor	0,24	interleukin-6	71,84	Hepatocyte growth factor	interleukin-6	15234(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|amod|END_ENTITY	Hepatocyte_growth_factor induces delayed STAT3 phosphorylation through interleukin-6 expression .
21072211	0	Hepatocyte_growth_factor	0,24	interleukin-6	35,48	Hepatocyte growth factor	interleukin-6	15234(Tax:10090)	16193(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|amod|END_ENTITY	Hepatocyte_growth_factor modulates interleukin-6 production in bone marrow derived macrophages : implications for inflammatory mediated diseases .
11479233	0	Hepatocyte_growth_factor	0,24	interleukin-8	144,157	Hepatocyte growth factor	interleukin-8	3082	3576	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nmod|expression expression|nmod|cytokines cytokines|amod|END_ENTITY	Hepatocyte_growth_factor / scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular_endothelial_growth_factor in head_and_neck_squamous_cell_carcinoma .
19184985	0	Hepatocyte_growth_factor	0,24	interleukin-8	49,62	Hepatocyte growth factor	interleukin-8	3082	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Hepatocyte_growth_factor induces hypoxia-related interleukin-8 expression in lung_adenocarcinoma cells .
22675553	0	Hepatocyte_growth_factor	0,24	osteopontin	35,46	Hepatocyte growth factor	osteopontin	3082	6696	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Hepatocyte_growth_factor increases osteopontin expression in human osteoblasts through PI3K , Akt , c-Src , and AP-1 signaling pathway .
8179588	0	Hepatocyte_growth_factor	0,24	transforming_growth_factor_alpha	35,67	Hepatocyte growth factor	transforming growth factor alpha	3082	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Hepatocyte_growth_factor regulates transforming_growth_factor_alpha in HepG2 hepatic cells .
23393351	0	Hepatocyte_growth_factor_activator_inhibitor_type-1	14,65	HAI-1	67,72	Hepatocyte growth factor activator inhibitor type-1	HAI-1	6692	6692	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Hepatocyte_growth_factor_activator_inhibitor_type-1 -LRB- HAI-1 -RRB- in prostate_cancer .
8314750	0	Hepatocyte_nuclear_factor-4	0,27	medium_chain_acyl-CoA_dehydrogenase	38,73	Hepatocyte nuclear factor-4	medium chain acyl-CoA dehydrogenase	25735(Tax:10116)	24158(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Hepatocyte_nuclear_factor-4 activates medium_chain_acyl-CoA_dehydrogenase gene transcription by interacting with a complex regulatory element .
11423471	0	Hepatocyte_nuclear_factor-4alpha	0,32	AMP-activated_protein_kinase	110,138	Hepatocyte nuclear factor-4alpha	AMP-activated protein kinase	3172	5563	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Hepatocyte_nuclear_factor-4alpha involved in type 1 maturity-onset diabetes_of_the_young is a novel target of AMP-activated_protein_kinase .
16051671	0	Hepatocyte_nuclear_factor-4alpha	0,32	apolipoprotein_AV	53,70	Hepatocyte nuclear factor-4alpha	apolipoprotein AV	3172	116519	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	Hepatocyte_nuclear_factor-4alpha regulates the human apolipoprotein_AV gene : identification of a novel response element and involvement in the control by peroxisome_proliferator-activated_receptor-gamma_coactivator-1alpha , AMP-activated_protein_kinase , and mitogen-activated protein kinase pathway .
19147806	0	Hepatocyte_nuclear_factor-4alpha	0,32	cellular_retinol-binding_protein_type_II	49,89	Hepatocyte nuclear factor-4alpha	cellular retinol-binding protein type II	3172	5948	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Hepatocyte_nuclear_factor-4alpha regulates human cellular_retinol-binding_protein_type_II gene expression in intestinal cells .
19228884	0	Hepatocyte_nuclear_factor-4alpha	0,32	concentrative_nucleoside_transporter-1	63,101	Hepatocyte nuclear factor-4alpha	concentrative nucleoside transporter-1	3172	9154	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Hepatocyte_nuclear_factor-4alpha and bile_acids regulate human concentrative_nucleoside_transporter-1 gene expression .
16051671	0	Hepatocyte_nuclear_factor-4alpha	0,32	peroxisome_proliferator-activated_receptor-gamma_coactivator-1alpha	154,221	Hepatocyte nuclear factor-4alpha	peroxisome proliferator-activated receptor-gamma coactivator-1alpha	3172	10891	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Hepatocyte_nuclear_factor-4alpha regulates the human apolipoprotein_AV gene : identification of a novel response element and involvement in the control by peroxisome_proliferator-activated_receptor-gamma_coactivator-1alpha , AMP-activated_protein_kinase , and mitogen-activated protein kinase pathway .
14521933	0	Hepatocyte_nuclear_factor_1	0,27	amylin	49,55	Hepatocyte nuclear factor 1	amylin	6927	3375	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Hepatocyte_nuclear_factor_1 negatively regulates amylin gene expression .
23922447	0	Hepatocyte_nuclear_factor_1	0,27	organic_cation_transporter_1	60,88	Hepatocyte nuclear factor 1	organic cation transporter 1	6927	6580	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Hepatocyte_nuclear_factor_1 regulates the expression of the organic_cation_transporter_1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene .
24819304	0	Hepatocyte_nuclear_factor_4a	0,28	CYP26A1	126,133	Hepatocyte nuclear factor 4a	CYP26A1	3172	1592	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Hepatocyte_nuclear_factor_4a -LRB- HNF4a -RRB- in coordination with retinoic_acid receptors increases all-trans-retinoic_acid-dependent CYP26A1 gene expression in HepG2 human hepatocytes .
23291635	0	Hepatocyte_nuclear_factor_6	0,27	CYP3A4	59,65	Hepatocyte nuclear factor 6	CYP3A4	3175	1576	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	Hepatocyte_nuclear_factor_6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells .
24022481	0	Hepatocyte_nuclear_factor_6	0,27	p53	102,105	Hepatocyte nuclear factor 6	p53	3175	7157	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Hepatocyte_nuclear_factor_6 suppresses the migration and invasive growth of lung_cancer cells through p53 and the inhibition of epithelial-mesenchymal transition .
19162039	0	Hepatoma-derived_growth_factor	0,30	SET_and_MYND_domain_containing_1	41,73	Hepatoma-derived growth factor	SET and MYND domain containing 1	3068	150572	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Hepatoma-derived_growth_factor represses SET_and_MYND_domain_containing_1 gene expression through interaction with C-terminal binding protein .
25938538	0	Hepatoma-derived_growth_factor	0,30	nucleolin	31,40	Hepatoma-derived growth factor	nucleolin	3068	4691	Gene	Gene	START_ENTITY|appos|axis axis|nsubj|END_ENTITY	Hepatoma-derived_growth_factor / nucleolin axis as a novel oncogenic pathway in liver_carcinogenesis .
18799614	0	Hepatoma_up-regulated_protein	0,29	TPX2	102,106	Hepatoma up-regulated protein	TPX2	494809(Tax:8355)	398174(Tax:8355)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|assembly assembly|nmod|END_ENTITY	Hepatoma_up-regulated_protein is required for chromatin-induced microtubule assembly independently of TPX2 .
20066738	0	Hepatopoietin_Cn	0,16	myeloid_cell_leukemia-1	95,118	Hepatopoietin Cn	myeloid cell leukemia-1	8125	4170	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Hepatopoietin_Cn suppresses apoptosis of human hepatocellular_carcinoma cells by up-regulating myeloid_cell_leukemia-1 .
9988272	0	Hephaestin	0,10	ceruloplasmin	14,27	Hephaestin	ceruloplasmin	15203(Tax:10090)	12870(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Hephaestin , a ceruloplasmin homologue implicated in intestinal iron transport , is defective in the sla mouse .
25576733	0	Hepsin	0,6	CDK11p58	16,24	Hepsin	CDK11p58	3249	984	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Hepsin inhibits CDK11p58 I.E. activity by suppressing unr expression and eIF-2a phosphorylation in prostate_cancer .
19938013	0	Hepsin	0,6	MYC	23,26	Hepsin	MYC	15451(Tax:10090)	17869(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate_cancer mouse model .
19911255	0	Hepsin	0,6	prostasin	17,26	Hepsin	prostasin	3249	5652	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Hepsin activates prostasin and cleaves the extracellular domain of the epidermal_growth_factor_receptor .
8102855	0	Her-2	7,12	erbB-2	0,6	Her-2	erbB-2	2064	2064	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	erbB-2 / Her-2 gene amplification and overexpression in parotid gland tumors .
20810050	0	Her-2	27,32	neu	33,36	Her-2	neu	2064	2064	Gene	Gene	association|nmod|START_ENTITY association|dep|END_ENTITY	Age related association of Her-2 / neu with prognostic markers in female breast_carcinoma .
21713147	0	Her-2_neu	0,9	Cerb-B2	11,18	Her-2 neu	Cerb-B2	2064	2064	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Her-2_neu -LRB- Cerb-B2 -RRB- expression in fine needle aspiration samples of breast_carcinoma : A pilot study comparing FISH , CISH and immunocytochemistry .
15026342	0	Her-4	97,102	epidermal_growth_factor_receptor	27,59	Her-4	epidermal growth factor receptor	2066	1956	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cell surface expression of epidermal_growth_factor_receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma .
19782563	0	Her2	20,24	ErbB2	14,19	Her2	ErbB2	2064	2064	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of ErbB2 -LRB- Her2 -RRB- expression with small molecule transcription factor mimics .
25128063	0	Her2	15,19	Lin28	0,5	Her2	Lin28	2064	79727	Gene	Gene	expression|amod|START_ENTITY predicts|nsubj|expression promotes|ccomp|predicts promotes|nsubj|END_ENTITY	Lin28 promotes Her2 expression and Lin28/Her2 predicts poorer survival in gastric_cancer .
26944953	0	Her2	47,51	Lin28A	0,6	Her2	Lin28A	2064	79727	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Lin28A and androgen_receptor expression in ER - / Her2 + _ breast_cancer .
7592681	0	Her2	71,75	Neu_differentiation_factor	11,37	Her2	Neu differentiation factor	2064	3084	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Neu_differentiation_factor with the extracellular domain of Her2 and Her3 .
22847003	0	Her2/Neu	46,54	ErbB2	39,44	Her2/Neu	ErbB2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Heat_shock factor Hsf1 cooperates with ErbB2 -LRB- Her2/Neu -RRB- protein to promote mammary tumorigenesis and metastasis .
15870086	0	Her2/neu	208,216	erbB-2	218,224	Her2/neu	erbB-2	2064	2064	Gene	Gene	oncogene|compound|START_ENTITY oncogene|dep|END_ENTITY	Antitumoral actions of the anti-obesity drug orlistat -LRB- XenicalTM -RRB- in breast_cancer cells : blockade of cell cycle progression , promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu -LRB- erbB-2 -RRB- oncogene .
1352299	0	Her2/neu	14,22	p185	40,44	Her2/neu	p185	2064	8661	Gene	Gene	Expression|nmod|START_ENTITY oncogene|nsubj|Expression oncogene|dobj|END_ENTITY	Expression of Her2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric_carcinoma .
22895471	0	Her2neu	48,55	CD8	65,68	Her2neu	CD8	2064	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Determining optimal cytotoxic activity of human Her2neu specific CD8 T cells by comparing the Cr51 release assay to the xCELLigence system .
20308324	0	Herc5	68,73	interferon_regulatory_factor_3	23,53	Herc5	interferon regulatory factor 3	51191	3661	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activation activation|amod|END_ENTITY	Positive regulation of interferon_regulatory_factor_3 activation by Herc5 via ISG15 modification .
2300571	0	Herculin	0,8	MyoD	33,37	Herculin	MyoD	17878(Tax:10090)	17927(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Herculin , a fourth member of the MyoD family of myogenic regulatory genes .
24168225	0	Hermansky-Pudlak_syndrome_type_4	19,51	HPS4	53,57	Hermansky-Pudlak syndrome type 4	HPS4	89781	89781	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the Hermansky-Pudlak_syndrome_type_4 -LRB- HPS4 -RRB- gene variants with cognitive function in patients with schizophrenia and healthy subjects .
23250771	0	Hermansky-Pudluck_syndrome-5	23,51	HPS5	53,57	Hermansky-Pudluck syndrome-5	HPS5	11234	11234	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A homolog of the human Hermansky-Pudluck_syndrome-5 -LRB- HPS5 -RRB- gene is responsible for the oa larval translucent mutants in the silkworm , Bombyx_mori .
27057372	0	Herpud1	12,19	Heme_Oxygenase-1	29,45	Herpud1	Heme Oxygenase-1	64209(Tax:10090)	15368(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Deletion of Herpud1 Enhances Heme_Oxygenase-1 Expression in a Mouse Model of Parkinson 's _ Disease .
11934884	0	Herstatin	0,9	epidermal_growth_factor	103,126	Herstatin	epidermal growth factor	2064	1950	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Herstatin , an autoinhibitor of the human epidermal_growth_factor receptor 2 tyrosine kinase , modulates epidermal_growth_factor signaling pathways resulting in growth_arrest .
24894488	0	Hes-1	93,98	GADD45a	102,109	Hes-1	GADD45a	3280	1647	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Hes-1 SUMOylation by protein inhibitor of activated STAT1 enhances the suppressing effect of Hes-1 on GADD45a expression to increase cell survival .
22302822	0	Hes-1	110,115	GluR1	14,19	Hes-1	GluR1	29577(Tax:10116)	50592(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	JNK1 inhibits GluR1 expression and GluR1-mediated calcium influx through phosphorylation and stabilization of Hes-1 .
19891787	0	Hes-1	23,28	Hes-6	0,5	Hes-1	Hes-6	3280	55502	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	Hes-6 , an inhibitor of Hes-1 , is regulated by 17beta-estradiol and promotes breast_cancer cell proliferation .
12065598	0	Hes-1	71,76	Notch-1	63,70	Hes-1	Notch-1	3280	4851	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	The human acid alpha-glucosidase gene is a novel target of the Notch-1 / Hes-1 signaling pathway .
19891787	0	Hes-6	0,5	Hes-1	23,28	Hes-6	Hes-1	55502	3280	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Hes-6 , an inhibitor of Hes-1 , is regulated by 17beta-estradiol and promotes breast_cancer cell proliferation .
21169257	0	Hes1	17,21	Gli1	41,45	Hes1	Gli1	3280	2735	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling : a potential mechanism of therapeutic resistance .
10851137	0	Hes1	36,40	Hes6	14,18	Hes1	Hes6	3280	55502	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	The bHLH gene Hes6 , an inhibitor of Hes1 , promotes neuronal differentiation .
18302773	0	Hes1	32,36	Hey2	0,4	Hes1	Hey2	3280	23493	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development .
20515776	0	Hes1	23,27	IkappaBalpha	0,12	Hes1	IkappaBalpha	15205(Tax:10090)	18035(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IkappaBalpha regulates Hes1 in osteoclast differentiation and resorption .
18287091	0	Hes1	48,52	Ikaros	0,6	Hes1	Ikaros	3280	10320	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line : implications for CD4 regulation .
25435940	0	Hes1	18,22	Nfia	36,40	Hes1	Nfia	3280	4774	Gene	Gene	activates|dobj|START_ENTITY activates|advcl|targeting targeting|dobj|END_ENTITY	miR-29a activates Hes1 by targeting Nfia in esophageal_carcinoma cell line TE-1 .
21389783	0	Hes1	0,4	Notch1	71,77	Hes1	Notch1	3280	4851	Gene	Gene	expression|amod|START_ENTITY downstream|nsubj|expression downstream|nmod|END_ENTITY	Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell_leukemia .
25624721	0	Hes1	0,4	Notch1	82,88	Hes1	Notch1	29577(Tax:10116)	25496(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Hes1 , an important gene for activation of hepatic stellate cells , is regulated by Notch1 and TGF-b/BMP signaling .
18308300	0	Hes1	54,58	Pax3	85,89	Hes1	Pax3	15205(Tax:10090)	18505(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Key basic helix-loop-helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development .
21169561	0	Hes1	46,50	Pax3	8,12	Hes1	Pax3	15205(Tax:10090)	18505(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY acetylation|nmod|regulation acetylation|nsubj|Role Role|nmod|END_ENTITY	Role of Pax3 acetylation in the regulation of Hes1 and Neurog2 .
18162173	0	Hes1	0,4	Runx2	44,49	Hes1	Runx2	3280	860	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation .
18636433	0	Hes1	60,64	TGF-alpha	0,9	Hes1	TGF-alpha	3280	7039	Gene	Gene	translocation|nmod|START_ENTITY induces|dobj|translocation induces|nsubj|END_ENTITY	TGF-alpha induces upregulation and nuclear translocation of Hes1 in glioma cell .
19914905	0	Hes1	0,4	interleukin_1beta	23,40	Hes1	interleukin 1beta	15205(Tax:10090)	16176(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Hes1 , a new target for interleukin_1beta in chondrocytes .
25435940	0	Hes1	18,22	miR-29a	0,7	Hes1	miR-29a	3280	407021	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	miR-29a activates Hes1 by targeting Nfia in esophageal_carcinoma cell line TE-1 .
10851137	0	Hes6	14,18	Hes1	36,40	Hes6	Hes1	55502	3280	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The bHLH gene Hes6 , an inhibitor of Hes1 , promotes neuronal differentiation .
23326414	0	Hes7	11,15	Tbx6	30,34	Hes7	Tbx6	84653(Tax:10090)	21389(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Control of Hes7 expression by Tbx6 , the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock .
19352502	0	Heterochromatin_protein_1	0,25	HP1	27,30	Heterochromatin protein 1	HP1	23468	23468	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Heterochromatin_protein_1 -LRB- HP1 -RRB- proteins do not drive pericentromeric cohesin enrichment in human cells .
18562319	0	Heterogeneous_nuclear_ribonucleoprotein_A1	0,42	Akt	119,122	Heterogeneous nuclear ribonucleoprotein A1	Akt	3178	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signaling signaling|compound|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_A1 regulates cyclin_D1 and c-myc internal ribosome entry site function through Akt signaling .
22664958	0	Heterogeneous_nuclear_ribonucleoprotein_F	0,41	angiotensinogen	53,68	Heterogeneous nuclear ribonucleoprotein F	angiotensinogen	98758(Tax:10090)	11606(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_F suppresses angiotensinogen gene expression and attenuates hypertension and kidney_injury in diabetic mice .
25701787	0	Heterogeneous_nuclear_ribonucleoprotein_K	0,41	NUF2	88,92	Heterogeneous nuclear ribonucleoprotein K	NUF2	3190	83540	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon_cancer cells .
23946508	0	Heterogeneous_nuclear_ribonucleoprotein_Q	0,41	SH2_domain-containing_phosphatase-2	66,101	Heterogeneous nuclear ribonucleoprotein Q	SH2 domain-containing phosphatase-2	10492	5781	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_Q is a novel substrate of SH2_domain-containing_phosphatase-2 .
26444903	0	Heterogeneous_ribonucleoprotein_R	0,33	arylalkylamine_N-acetyltransferase	44,78	Heterogeneous ribonucleoprotein R	arylalkylamine N-acetyltransferase	319110(Tax:10116)	25120(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|amod|END_ENTITY	Heterogeneous_ribonucleoprotein_R regulates arylalkylamine_N-acetyltransferase synthesis via internal ribosomal entry site-mediated translation in a circadian manner .
16936074	0	Hex	0,3	beta-catenin	14,26	Hex	beta-catenin	373590(Tax:8355)	399274(Tax:8355)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal .
15855166	0	Hexim1	47,53	cyclin	20,26	Hexim1	cyclin	10614	5111	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat .
24780297	0	Hexokinase_2	0,12	CDK2	47,51	Hexokinase 2	CDK2	3099	1017	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Hexokinase_2 regulates G1/S checkpoint through CDK2 in cancer-associated fibroblasts .
14672622	0	Hexokinase_II	0,13	hypoxia-inducible_factor_1_alpha	68,100	Hexokinase II	hypoxia-inducible factor 1 alpha	3099	3091	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Hexokinase_II and VEGF expression in liver_tumors : correlation with hypoxia-inducible_factor_1_alpha and its significance .
18302773	0	Hey2	0,4	Hes1	32,36	Hey2	Hes1	23493	3280	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development .
24155934	0	Hfe	73,76	Tfr2	105,109	Hfe	Tfr2	15216(Tax:10090)	50765(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin_receptor_2 -LRB- Tfr2 -RRB- do not interact .
14993190	0	Hfp	11,14	dmyc	36,40	Hfp	dmyc	38173(Tax:7227)	31310(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation .
20667914	0	Hfp	0,3	myc	24,27	Hfp	myc	38173(Tax:7227)	31310(Tax:7227)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner .
8581971	0	Hg2	11,14	Ca2	29,32	Hg2	Ca2	283955	760	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Effects of Hg2 + on cytosolic Ca2 + in isolated skate hepatocytes .
26728554	0	Hhex	32,36	Cdkn2a	86,92	Hhex	Cdkn2a	3087	1029	Gene	Gene	requires|dobj|START_ENTITY requires|xcomp|enable enable|dobj|repression repression|nmod|END_ENTITY	Acute myeloid_leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a .
16764824	0	Hhex	0,4	endothelial_cell-specific_molecule_1	30,66	Hhex	endothelial cell-specific molecule 1	3087	11082	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Hhex is a direct repressor of endothelial_cell-specific_molecule_1 -LRB- ESM-1 -RRB- .
19017647	0	Hho1p	40,45	histone_H4	79,89	Hho1p	histone H4	855976(Tax:4932)	855701(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Saccharomyces_cerevisiae linker histone Hho1p functionally interacts with core histone_H4 and negatively regulates the establishment of transcriptionally silent chromatin .
26689994	0	HiF-1a	107,113	Sp1	145,148	HiF-1a	Sp1	3091	6667	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Monoamine_oxidase_B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1a and with transcription factors Sp1 and Sp3 .
17826007	0	HiNF-P	60,66	HiNF-P	76,82	HiNF-P	HiNF-P	25988	25988	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the histone_nuclear_factor_P -LRB- HiNF-P -RRB- gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition .
17826007	0	HiNF-P	76,82	HiNF-P	60,66	HiNF-P	HiNF-P	25988	25988	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the histone_nuclear_factor_P -LRB- HiNF-P -RRB- gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition .
17826007	0	HiNF-P	60,66	histone_nuclear_factor_P	34,58	HiNF-P	histone nuclear factor P	25988	25988	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional activation of the histone_nuclear_factor_P -LRB- HiNF-P -RRB- gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition .
17826007	0	HiNF-P	76,82	histone_nuclear_factor_P	34,58	HiNF-P	histone nuclear factor P	25988	25988	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional activation of the histone_nuclear_factor_P -LRB- HiNF-P -RRB- gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition .
19035221	0	Hic-5	1,6	ARA55	7,12	Hic-5	ARA55	7041	7041	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	-LSB- Hic-5 / ARA55 inhibits the growth of Lovo cells by up-regulating the expression of P27 -RSB- .
10838081	0	Hic-5	19,24	CAKbeta	43,50	Hic-5	CAKbeta	7041	2185	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn .
17550607	0	Hic-5	27,32	FAK	130,133	Hic-5	FAK	84574(Tax:10116)	25614(Tax:10116)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK .
12153727	0	Hic-5	0,5	GIT1	21,25	Hic-5	GIT1	7041	28964	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hic-5 interacts with GIT1 with a different binding mode from paxillin .
15706082	0	Hic-5	117,122	LIM	104,107	Hic-5	LIM	7041	10611	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein , Hic-5 .
18762808	0	Hic-5	80,85	LIM	68,71	Hic-5	LIM	7041	10611	Gene	Gene	ARA55|compound|START_ENTITY ARA55|compound|END_ENTITY	Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5 / ARA55 .
12177201	0	Hic-5	51,56	dopamine_transporter	105,125	Hic-5	dopamine transporter	7041	6531	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine_transporter .
10092676	0	Hic-5	0,5	paxillin	9,17	Hic-5	paxillin	7041	5829	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Hic-5 , a paxillin homologue , binds to the protein-tyrosine_phosphatase_PEST -LRB- PTP-PEST -RRB- through its LIM 3 domain .
10092676	0	Hic-5	0,5	protein-tyrosine_phosphatase_PEST	42,75	Hic-5	protein-tyrosine phosphatase PEST	7041	5782	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Hic-5 , a paxillin homologue , binds to the protein-tyrosine_phosphatase_PEST -LRB- PTP-PEST -RRB- through its LIM 3 domain .
20154726	0	Hic1	38,42	ephrin-A1	98,107	Hic1	ephrin-A1	15248(Tax:10090)	13636(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A potential tumor suppressor role for Hic1 in breast_cancer through transcriptional repression of ephrin-A1 .
14960278	0	Hif-1_prolyl_hydroxylase	34,58	Cdk4	20,24	Hif-1 prolyl hydroxylase	Cdk4	40633(Tax:7227)	36854(Tax:7227)	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	Drosophila cyclin_D / Cdk4 requires Hif-1_prolyl_hydroxylase to drive cell growth .
26030758	0	Hif-1a	18,24	MiR-335	0,7	Hif-1a	MiR-335	15251(Tax:10090)	723930(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	MiR-335 Regulates Hif-1a to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models .
18835464	0	Hif-1alpha	98,108	Vegf	85,89	Hif-1alpha	Vegf	3091	7422	Gene	Gene	expression|compound|START_ENTITY regulates|nmod|expression regulates|dobj|expression expression|nmod|END_ENTITY	CCN family 2/connective tissue growth factor -LRB- CCN2/CTGF -RRB- regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line , HCS-2 / 8 , under hypoxic condition .
23878241	0	Higd-1a	0,7	Opa1	23,27	Higd-1a	Opa1	25994	4976	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria .
25222915	0	High-Mobility_Group_Box_1	14,39	HMGB1	49,54	High-Mobility Group Box 1	HMGB1	3146	3146	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Extracellular High-Mobility_Group_Box_1 Protein -LRB- HMGB1 -RRB- as a Mediator of Persistent Pain .
15713121	0	High-mobility-group_A1	0,22	HMGA1	24,29	High-mobility-group A1	HMGA1	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	High-mobility-group_A1 -LRB- HMGA1 -RRB- proteins down-regulate the expression of the recombination_activating_gene_2 -LRB- RAG2 -RRB- .
17290307	0	High-mobility_group_A1	0,22	p53	32,35	High-mobility group A1	p53	3159	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	High-mobility_group_A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 .
20844833	0	High-mobility_group_box-1	0,25	HMGB1	35,40	High-mobility group box-1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High-mobility_group_box-1 protein -LRB- HMGB1 -RRB- is increased in antineutrophilic cytoplasmatic antibody -LRB- ANCA -RRB- - associated vasculitis with renal manifestations .
15803152	0	High-mobility_group_box_1	0,25	HMGB1	35,40	High-mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High-mobility_group_box_1 protein -LRB- HMGB1 -RRB- : nuclear weapon in the immune arsenal .
16513409	0	High-mobility_group_box_1	0,25	HMGB1	27,32	High-mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High-mobility_group_box_1 -LRB- HMGB1 -RRB- protein : friend and foe .
24412753	0	High-mobility_group_box_1	0,25	HMGB1	27,32	High-mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High-mobility_group_box_1 -LRB- HMGB1 -RRB- protein regulates tumor-associated cell migration through the interaction with BTB domain .
24244627	0	High-mobility_group_box_1	0,25	Toll-like_receptor_4	65,85	High-mobility group box 1	Toll-like receptor 4	15289(Tax:10090)	21898(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	High-mobility_group_box_1 inhibits gastric ulcer_healing through Toll-like_receptor_4 and receptor_for_advanced_glycation_end_products .
24893328	0	High-mobility_group_box_1	0,25	aquaporin_4	39,50	High-mobility group box 1	aquaporin 4	25459(Tax:10116)	25293(Tax:10116)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	High-mobility_group_box_1 up-regulates aquaporin_4 expression via microglia-astrocyte interaction .
23268406	0	High-mobility_group_box_protein_1	1,34	interleukin-8	75,88	High-mobility group box protein 1	interleukin-8	3146	3576	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	-LSB- High-mobility_group_box_protein_1 in synergy with interleukin-1b promotes interleukin-8 expression in human airway epithelial cells in vitro -RSB- .
26954343	0	High_Mobility_Group-Box_1	0,25	HMGB1	27,32	High Mobility Group-Box 1	HMGB1	3146	3146	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	High_Mobility_Group-Box_1 -LRB- HMGB1 -RRB- levels are increased in amniotic_fluid of women with intra-amniotic_inflammation-determined preterm_birth , and the source may be the damaged fetal membranes .
16341121	0	High_Mobility_Group_A1	0,22	HMGA1	24,29	High Mobility Group A1	HMGA1	3159	3159	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	High_Mobility_Group_A1 -LRB- HMGA1 -RRB- proteins interact with p53 and inhibit its apoptotic activity .
27001612	0	High_Mobility_Group_A1	4,26	Matrix_Metalloproteinase-2	130,156	High Mobility Group A1	Matrix Metalloproteinase-2	3159	4313	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nsubj|gene	The High_Mobility_Group_A1 -LRB- HMGA1 -RRB- gene is highly overexpressed in human uterine serous_carcinomas and carcinosarcomas and drives Matrix_Metalloproteinase-2 -LRB- MMP-2 -RRB- in a subset of tumors .
16644144	0	High_Mobility_Group_B1	48,70	HMGB1	72,77	High Mobility Group B1	HMGB1	3146	3146	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Cloning the genes and DNA binding properties of High_Mobility_Group_B1 -LRB- HMGB1 -RRB- proteins from the human blood_flukes Schistosoma_mansoni and Schistosoma_japonicum .
26118980	0	High_Mobility_Group_Box-1_Protein	15,48	HMGB1	50,55	High Mobility Group Box-1 Protein	HMGB1	3146	3146	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of High_Mobility_Group_Box-1_Protein -LRB- HMGB1 -RRB- with Clinicopathological Parameters in Primary Retinoblastoma .
26226834	0	High_Mobility_Group_Box_1	43,68	Endothelin-1	0,12	High Mobility Group Box 1	Endothelin-1	3146	1906	Gene	Gene	Expression|nmod|START_ENTITY Upregulates|dobj|Expression Upregulates|nsubj|END_ENTITY	Endothelin-1 Upregulates the Expression of High_Mobility_Group_Box_1 in Human Bronchial Epithelial Cells .
25275029	0	High_Mobility_Group_Box_1	27,52	HMGB1	54,59	High Mobility Group Box 1	HMGB1	3146	3146	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Prognostic Significance of High_Mobility_Group_Box_1 -LRB- HMGB1 -RRB- Expression in Patients with Colorectal_Cancer .
25549101	0	High_Mobility_Group_Box_1	8,33	HMGB1	35,40	High Mobility Group Box 1	HMGB1	3146	3146	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of High_Mobility_Group_Box_1 -LRB- HMGB1 -RRB- in SCA17 Pathogenesis .
16166307	0	High_mobility_group_A1	0,22	MYCN	49,53	High mobility group A1	MYCN	3159	4613	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	High_mobility_group_A1 is a molecular target for MYCN in human neuroblastoma .
25043672	0	High_mobility_group_box_1	0,25	HMGB-1	35,41	High mobility group box 1	HMGB-1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High_mobility_group_box_1 protein -LRB- HMGB-1 -RRB- : a pathogenic role in preeclampsia ?
15653118	0	High_mobility_group_box_1	0,25	HMGB1	27,32	High mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High_mobility_group_box_1 -LRB- HMGB1 -RRB- protein : possible amplification signal in the pathogenesis of falciparum_malaria .
21241404	0	High_mobility_group_box_1	0,25	HMGB1	27,32	High mobility group box 1	HMGB1	3146	3146	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	High_mobility_group_box_1 -LRB- HMGB1 -RRB- levels in the placenta and in serum in preeclampsia .
21441719	0	High_mobility_group_box_1	0,25	HMGB1	27,32	High mobility group box 1	HMGB1	403170(Tax:9615)	403170(Tax:9615)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High_mobility_group_box_1 -LRB- HMGB1 -RRB- protein is present in the cerebrospinal fluid of dogs with encephalitis .
26105447	1	High_mobility_group_box_1	7,32	HMGB1	42,47	High mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High_mobility_group_box_1 protein -LRB- HMGB1 -RRB- : A pathogenic role in preeclampsia ?
22841886	0	High_mobility_group_box_1	0,25	Toll_like_receptor_4	36,56	High mobility group box 1	Toll like receptor 4	15289(Tax:10090)	21898(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	High_mobility_group_box_1 activates Toll_like_receptor_4 signaling in hepatic stellate cells .
21656024	0	High_mobility_group_box_1	0,25	dipeptidyl_peptidase-IV	50,73	High mobility group box 1	dipeptidyl peptidase-IV	3146	1803	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	High_mobility_group_box_1 is a novel substrate of dipeptidyl_peptidase-IV .
21871094	0	High_mobility_group_box_protein_1	0,33	lipopolysaccharide_or_IL-1	50,76	High mobility group box protein 1	lipopolysaccharide or IL-1	3146	3552	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	High_mobility_group_box_protein_1 in complex with lipopolysaccharide_or_IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts .
12952972	0	High_molecular_weight_kininogen	0,31	Mac-1	86,91	High molecular weight kininogen	Mac-1	3827	3684	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|bridging bridging|dobj|Ib Ib|compound|END_ENTITY	High_molecular_weight_kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib .
8034694	0	High_molecular_weight_kininogen	0,31	Mac-1	41,46	High molecular weight kininogen	Mac-1	3827	3684	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	High_molecular_weight_kininogen binds to Mac-1 on neutrophils by its heavy chain -LRB- domain 3 -RRB- and its light chain -LRB- domain 5 -RRB- .
25484218	0	Hikeshi	70,77	Hsp70	116,121	Hikeshi	Hsp70	51501	3308	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Crystallization and preliminary X-ray crystallographic study of human Hikeshi , a new nuclear transport receptor for Hsp70 .
16014379	0	Hint1	28,33	Pontin	49,55	Hint1	Pontin	3094	8607	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription .
19190990	0	Hip	98,101	Umbrea	0,6	HP1	Umbrea	34119(Tax:7227)	33661(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Umbrea , a chromo shadow domain protein in Drosophila_melanogaster heterochromatin , interacts with Hip , HP1 and HOAP .
12537263	0	Hip	0,3	familial_Mediterranean_fever	33,61	Hip	familial Mediterranean fever	6159	4210	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Hip involvement in patients with familial_Mediterranean_fever .
17620340	0	Hip	0,3	granzyme_B	35,45	Hip	granzyme B	6767	3002	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Hip is a pro-survival substrate of granzyme_B .
15754313	0	Hip	56,59	hedgehog-interacting_protein	26,54	Hip	hedgehog-interacting protein	64399	64399	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the human hedgehog-interacting_protein -LRB- Hip -RRB- in the normal and diseased pancreas .
10693560	0	Hip	0,3	hip	44,47	Hip	hip	6159	6159	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Hip and knee replacement after longstanding hip arthrodesis .
14527403	0	Hip-2	25,30	E2-25K	18,24	Hip-2	E2-25K	3093	3093	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Essential role of E2-25K / Hip-2 in mediating amyloid-beta neurotoxicity .
18710920	0	Hip-2	7,12	E2-25K	0,6	Hip-2	E2-25K	53323(Tax:10090)	53323(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	E2-25K / Hip-2 regulates caspase-12 in ER stress-mediated Abeta_neurotoxicity .
18710920	0	Hip-2	7,12	caspase-12	23,33	Hip-2	caspase-12	53323(Tax:10090)	12364(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	E2-25K / Hip-2 regulates caspase-12 in ER stress-mediated Abeta_neurotoxicity .
10585161	0	Hip-2	50,55	huntingtin-interacting_protein-2	16,48	Hip-2	huntingtin-interacting protein-2	53323(Tax:10090)	53323(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of huntingtin-interacting_protein-2 -LRB- Hip-2 -RRB- mRNA in the developing mouse brain .
16364650	0	Hip1	114,118	Hippi	53,58	Hip1	Hippi	3092	55081	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Induction of apoptosis in cells expressing exogenous Hippi , a molecular partner of huntingtin-interacting protein Hip1 .
20965177	0	Hip2	0,4	cyclin_B1	20,29	Hip2	cyclin B1	3093	891	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hip2 interacts with cyclin_B1 and promotes its degradation through the ubiquitin proteasome pathway .
21561986	0	Hipk	72,76	JNK	37,40	Hipk	JNK	38070(Tax:7227)	44801(Tax:7227)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus .
23782693	0	Hipk2	132,137	C/EBPb	73,79	Hipk2	C/EBPb	15258(Tax:10090)	12608(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction and cooperation of the CCAAT-box enhancer-binding protein b -LRB- C/EBPb -RRB- with the homeodomain-interacting_protein_kinase_2 -LRB- Hipk2 -RRB- .
21785465	0	Hipk2	0,5	p53	22,25	Hipk2	p53	15258(Tax:10090)	22060(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Hipk2 cooperates with p53 to suppress y-ray radiation-induced mouse thymic_lymphoma .
12745083	0	Hippi	47,52	Apoptin	24,31	Hippi	Apoptin	55081	1494446(Tax:12618)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The viral death protein Apoptin interacts with Hippi , the protein interactor of Huntingtin-interacting_protein_1 .
16364650	0	Hippi	53,58	Hip1	114,118	Hippi	Hip1	55081	3092	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Induction of apoptosis in cells expressing exogenous Hippi , a molecular partner of huntingtin-interacting protein Hip1 .
17874297	0	Hippi	20,25	Rybp	0,4	Hippi	Rybp	73916(Tax:10090)	56353(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rybp interacts with Hippi and enhances Hippi-mediated apoptosis .
11238922	0	Hir1p	35,40	HIRA	0,4	Hir1p	HIRA	852275(Tax:4932)	7290	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	HIRA , the human homologue of yeast Hir1p and Hir2p , is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression .
1529792	0	Histaminase	0,11	diamine_oxidase	76,91	Histaminase	diamine oxidase	65029(Tax:10116)	65029(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Histaminase activity in rat lung and its comparison with intestinal mucosal diamine_oxidase .
191838	0	Histaminase	0,11	diamine_oxidase	13,28	Histaminase	diamine oxidase	26	26	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Histaminase -LRB- diamine_oxidase -RRB- activity in human tumors : an expression of a mature genome .
26206890	0	Histamine_N-Methyltransferase	17,46	HNMT	53,57	Histamine N-Methyltransferase	HNMT	3176	3176	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the Histamine_N-Methyltransferase gene , HNMT , are Associated with Non-Syndromic Autosomal Recessive Intellectual Disability .
26206890	0	Histamine_N-Methyltransferase	17,46	HNMT	53,57	Histamine N-Methyltransferase	HNMT	3176	3176	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the Histamine_N-Methyltransferase gene , HNMT , are Associated with Non-Syndromic Autosomal Recessive Intellectual Disability .
24970226	0	Histidine-Proline-Rich_Glycoprotein	12,47	AMP_Deaminase	86,99	Histidine-Proline-Rich Glycoprotein	AMP Deaminase	3273	270	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of Histidine-Proline-Rich_Glycoprotein as Zinc_Chaperone for Skeletal Muscle AMP_Deaminase .
11134179	0	Histidine-rich_glycoprotein	0,27	thrombospondin-1	66,82	Histidine-rich glycoprotein	thrombospondin-1	3273	7057	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Histidine-rich_glycoprotein inhibits the antiangiogenic effect of thrombospondin-1 .
2015894	0	Histidine_decarboxylase	0,23	gastrin	70,77	Histidine decarboxylase	gastrin	24443(Tax:10116)	25320(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Histidine_decarboxylase gene expression in rat fundus is regulated by gastrin .
21179510	0	Histidine_domain-protein_tyrosine_phosphatase	0,45	Grb2	61,65	Histidine domain-protein tyrosine phosphatase	Grb2	25930	2885	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Histidine_domain-protein_tyrosine_phosphatase interacts with Grb2 and GrpL .
18682386	0	Histone_2B	0,10	H2B	12,15	Histone 2B	H2B	8349	8349	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Histone_2B -LRB- H2B -RRB- expression is confined to a proper NAD + / NADH redox status .
26343742	0	Histone_Deacetylase	0,19	EGR1	121,125	Histone Deacetylase	EGR1	9734	1958	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Histone_Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early_Growth_Response_Protein_1 -LRB- EGR1 -RRB- in Colorectal_Cancer_Cells .
25864671	0	Histone_Deacetylase	27,46	HDAC	48,52	Histone Deacetylase	HDAC	9734	9734	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Chemical Tools for Probing Histone_Deacetylase -LRB- HDAC -RRB- Activity .
26418117	0	Histone_Deacetylase	17,36	HDAC	38,42	Histone Deacetylase	HDAC	9734	9734	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Light-Controlled Histone_Deacetylase -LRB- HDAC -RRB- Inhibitors : Towards Photopharmacological Chemotherapy .
25760728	0	Histone_Deacetylase	15,34	TRPM2	0,5	Histone Deacetylase	TRPM2	9734	7226	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|compound|END_ENTITY	TRPM2 Mediates Histone_Deacetylase Inhibition-Induced Apoptosis in Bladder_Cancer Cells .
25642316	0	Histone_Deacetylase_2	36,57	HDAC2	59,64	Histone Deacetylase 2	HDAC2	15182(Tax:10090)	15182(Tax:10090)	Gene	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|appos|END_ENTITY	Kinetically Selective Inhibitors of Histone_Deacetylase_2 -LRB- HDAC2 -RRB- as Cognition Enhancers .
26653328	0	Histone_Deacetylase_6	83,104	HDAC6	106,111	Histone Deacetylase 6	HDAC6	10013	10013	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Synthesis and Biological Investigation of Oxazole_Hydroxamates as Highly Selective Histone_Deacetylase_6 -LRB- HDAC6 -RRB- Inhibitors .
18611290	0	Histone_deacetylase	0,19	GDNF	53,57	Histone deacetylase	GDNF	9734	2668	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	Histone_deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons .
12810630	0	Histone_deacetylase	0,19	RECK	43,47	Histone deacetylase	RECK	9734	8434	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Histone_deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion .
21367844	0	Histone_deacetylase	0,19	Rap1GAP	42,49	Histone deacetylase	Rap1GAP	9734	5909	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	Histone_deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid_tumor cells .
9512514	0	Histone_deacetylase	0,19	Rpd3	32,36	Histone deacetylase	Rpd3	855987(Tax:4932)	855386(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Histone_deacetylase activity of Rpd3 is important for transcriptional repression in vivo .
19843519	0	Histone_deacetylase-1	0,21	interleukin-1beta	98,115	Histone deacetylase-1	interleukin-1beta	3065	3553	Gene	Gene	enriched|nsubjpass|START_ENTITY enriched|nmod|END_ENTITY	Histone_deacetylase-1 is enriched at the platelet-derived_growth_factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab_p65 and interferon_regulatory_factor-1 .
13679859	0	Histone_deacetylase_1	0,21	RhoB	49,53	Histone deacetylase 1	RhoB	3065	388	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Histone_deacetylase_1 represses the small GTPase RhoB expression in human nonsmall_lung_carcinoma cell line .
25072962	0	Histone_deacetylase_2	0,21	p53	31,34	Histone deacetylase 2	p53	3066	7157	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Histone_deacetylase_2 controls p53 and is a critical factor in tumorigenesis .
25973305	0	Histone_deacetylase_3	0,21	DTWD1	57,62	Histone deacetylase 3	DTWD1	8841	56986	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Histone_deacetylase_3 inhibits new tumor suppressor gene DTWD1 in gastric_cancer .
15356147	0	Histone_deacetylase_3	0,21	TNF	140,143	Histone deacetylase 3	TNF	8841	7124	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Histone_deacetylase_3 , a class I histone deacetylase , suppresses MAPK11-mediated activating_transcription_factor-2 activation and represses TNF gene expression .
24565863	0	Histone_deacetylase_3	0,21	Tbx5	32,36	Histone deacetylase 3	Tbx5	15183(Tax:10090)	21388(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Histone_deacetylase_3 modulates Tbx5 activity to regulate early cardiogenesis .
15356147	0	Histone_deacetylase_3	0,21	activating_transcription_factor-2	81,114	Histone deacetylase 3	activating transcription factor-2	8841	1386	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Histone_deacetylase_3 , a class I histone deacetylase , suppresses MAPK11-mediated activating_transcription_factor-2 activation and represses TNF gene expression .
16298343	0	Histone_deacetylase_3	0,21	p15	32,35	Histone deacetylase 3	p15	8841	1030	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Histone_deacetylase_3 represses p15 -LRB- INK4b -RRB- and p21 -LRB- WAF1/cip1 -RRB- transcription by interacting with Sp1 .
15292260	0	Histone_deacetylase_3	0,21	runx2	37,42	Histone deacetylase 3	runx2	8841	860	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Histone_deacetylase_3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation .
12668657	0	Histone_deacetylase_4	0,21	53BP1	37,42	Histone deacetylase 4	53BP1	9759	7158	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Histone_deacetylase_4 interacts with 53BP1 to mediate the DNA damage response .
25068794	0	Histone_deacetylase_4	0,21	Sp3	78,81	Histone deacetylase 4	Sp3	9759	6670	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Histone_deacetylase_4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di -LRB- 2-ethylhexyl -RRB- phthalate -LRB- DEHP -RRB- , determining neuronal_death .
11114188	0	Histone_deacetylase_4	0,21	extracellular_signal-regulated_kinases_1_and_2	38,84	Histone deacetylase 4	extracellular signal-regulated kinases 1 and 2	208727(Tax:10090)	26417;26413	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Histone_deacetylase_4 associates with extracellular_signal-regulated_kinases_1_and_2 , and its cellular localization is regulated by oncogenic Ras .
12019172	0	Histone_deacetylase_5	0,21	p53	31,34	Histone deacetylase 5	p53	10014	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Histone_deacetylase_5 is not a p53 target gene , but its overexpression inhibits tumor cell growth and induces apoptosis .
26471297	0	Histone_deacetylase_6	0,21	NLRP3	43,48	Histone deacetylase 6	NLRP3	10013	114548	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	Histone_deacetylase_6 negatively regulates NLRP3 inflammasome activation .
21421902	0	Histone_deacetylase_6	0,21	estrogen_receptor_alpha	32,55	Histone deacetylase 6	estrogen receptor alpha	10013	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Histone_deacetylase_6 regulates estrogen_receptor_alpha in uterine leiomyoma .
18636984	0	Histone_deacetylase_6	0,21	microtubule-associated_protein_tau	41,75	Histone deacetylase 6	microtubule-associated protein tau	10013	4137	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Histone_deacetylase_6 interacts with the microtubule-associated_protein_tau .
17997710	0	Histone_deacetylase_7	0,21	Runx2	38,43	Histone deacetylase 7	Runx2	56233(Tax:10090)	12393(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Histone_deacetylase_7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner .
25038252	0	Hiwi2	23,28	Piwi	10,14	Hiwi2	Piwi	143689	9271	Gene	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells .
1516826	0	Hlf	0,3	E2A	92,95	Hlf	E2A	3131	6929	Gene	Gene	shows|nsubj|START_ENTITY shows|advcl|fusion fusion|nmod|END_ENTITY	Hlf , a novel hepatic bZIP protein , shows altered DNA-binding properties following fusion to E2A in t -LRB- 17 ; 19 -RRB- acute_lymphoblastic_leukemia .
12128222	0	Hlp	28,31	heart_LIM_protein	4,21	Hlp	heart LIM protein	68337(Tax:10090)	68337(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The heart_LIM_protein gene -LRB- Hlp -RRB- , expressed in the developing and adult heart , defines a new tissue-specific LIM-only protein family .
7729546	0	Hlr1	60,64	Hlr1-ps1	82,90	Hlr1	Hlr1-ps1	13207(Tax:10090)	111326(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Assignment to chromosome 11 of mouse p68 RNA helicase gene -LRB- Hlr1 -RRB- and pseudogene -LRB- Hlr1-ps1 -RRB- .
7729546	0	Hlr1	60,64	p68	37,40	Hlr1	p68	13207(Tax:10090)	13207(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment to chromosome 11 of mouse p68 RNA helicase gene -LRB- Hlr1 -RRB- and pseudogene -LRB- Hlr1-ps1 -RRB- .
7729546	0	Hlr1-ps1	82,90	Hlr1	60,64	Hlr1-ps1	Hlr1	111326(Tax:10090)	13207(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Assignment to chromosome 11 of mouse p68 RNA helicase gene -LRB- Hlr1 -RRB- and pseudogene -LRB- Hlr1-ps1 -RRB- .
7729546	0	Hlr1-ps1	82,90	p68	37,40	Hlr1-ps1	p68	111326(Tax:10090)	13207(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment to chromosome 11 of mouse p68 RNA helicase gene -LRB- Hlr1 -RRB- and pseudogene -LRB- Hlr1-ps1 -RRB- .
11410365	0	Hmga1	43,48	Hmgiy	36,41	Hmga1	Hmgiy	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence and analysis of the murine Hmgiy -LRB- Hmga1 -RRB- gene locus .
25150295	0	Hmga2	0,5	RUNX1	33,38	Hmga2	RUNX1	15364(Tax:10090)	12394(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice .
11410365	0	Hmgiy	36,41	Hmga1	43,48	Hmgiy	Hmga1	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence and analysis of the murine Hmgiy -LRB- Hmga1 -RRB- gene locus .
26566865	0	Hmgn1	0,5	C/EBPb	25,31	Hmgn1	C/EBPb	15312(Tax:10090)	12608(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Hmgn1 acts downstream of C/EBPb to regulate the decidualization of uterine stromal cells in mice .
25793372	0	Hmt1	98,102	Rpd3	27,31	Hmt1	Rpd3	56052	3065	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Correction : Recruitment of Rpd3 to the Telomere Depends on the Protein Arginine Methyltransferase Hmt1 .
20053728	0	Hmt1p	33,38	Npl3p	105,110	Hmt1p	Npl3p	852322(Tax:4932)	852042(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p .
19379485	0	Hmx1	21,25	H6_Homeobox_1	6,19	Hmx1	H6 Homeobox 1	15371(Tax:10090)	15371(Tax:10090)	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Mouse H6_Homeobox_1 -LRB- Hmx1 -RRB- mutations cause cranial_abnormalities and reduced body mass .
21539831	0	Hmx4	0,4	Sonic_hedgehog	15,29	Hmx4	Sonic hedgehog	751654(Tax:7955)	6469	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Hmx4 regulates Sonic_hedgehog signaling through control of retinoic_acid synthesis during forebrain patterning .
1833625	0	HnRNP	26,31	SnRNP	3,8	HnRNP	SnRNP	3183	57819	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA .
21642356	0	HnRNPA2B1	13,22	Fyn	0,3	HnRNPA2B1	Fyn	3181	2534	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic_cancer .
9563502	0	HnRNP_L	52,59	Polypyrimidine_tract-binding_protein	0,36	HnRNP L	Polypyrimidine tract-binding protein	3191	5725	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Polypyrimidine_tract-binding_protein interacts with HnRNP_L .
21193557	0	Hnf1a	0,5	MafA	40,44	Hnf1a	MafA	6927	389692	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Hnf1a -LRB- MODY3 -RRB- regulates b-cell-enriched MafA transcription factor expression .
15142986	0	Hnf1beta	26,34	MODY5	36,41	Hnf1beta	MODY5	21410(Tax:10090)	6928	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Selective deletion of the Hnf1beta -LRB- MODY5 -RRB- gene in beta-cells leads to altered gene expression and defective insulin release .
11287181	0	Hnf3beta	85,93	Foxa2	78,83	Hnf3beta	Foxa2	15376(Tax:10090)	15376(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of essential sequence motifs in the node/notochord enhancer of Foxa2 -LRB- Hnf3beta -RRB- gene that are conserved across vertebrate species .
11145965	0	Hnf4alpha	173,182	FTF	137,140	Hnf4alpha	FTF	15378(Tax:10090)	26424(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The mouse fetoprotein_transcription_factor -LRB- FTF -RRB- gene promoter is regulated by three GATA elements with tandem E box and Nkx motifs , and FTF in turn activates the Hnf3beta , Hnf4alpha , and Hnf1alpha gene promoters .
24631193	0	Hnf6	61,65	Rbpj	93,97	Hnf6	Rbpj	15379(Tax:10090)	19664(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj .
21253564	0	Hnrnpa1	18,25	Quaking	0,7	Hnrnpa1	Quaking	3178	19317(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Quaking regulates Hnrnpa1 expression through its 3 ' UTR in oligodendrocyte precursor cells .
20417178	0	Ho-1	16,20	EGR-1	0,5	Ho-1	EGR-1	15368(Tax:10090)	13653(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	EGR-1 regulates Ho-1 expression induced by cigarette smoke .
15775961	0	Hof1	15,19	Grr1	27,31	Hof1	Grr1	855048(Tax:4932)	853552(Tax:4932)	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|appos|END_ENTITY	Degradation of Hof1 by SCF -LRB- Grr1 -RRB- is important for actomyosin contraction during cytokinesis in yeast .
23638004	0	Holliday_Junction-Recognizing_Protein	21,58	HJURP	14,19	Holliday Junction-Recognizing Protein	HJURP	55355	55355	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Modulation of HJURP -LRB- Holliday_Junction-Recognizing_Protein -RRB- levels is correlated with glioblastoma cells survival .
25865500	0	HomeoBox_1	21,31	PHYTOCHROME-INTERACTING_FACTOR_1	120,152	HomeoBox 1	PHYTOCHROME-INTERACTING FACTOR 1	839740(Tax:3702)	816538(Tax:3702)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Arabidopsis_thaliana HomeoBox_1 -LRB- AtHB1 -RRB- , a Homedomain-Leucine_Zipper_I -LRB- HD-Zip_I -RRB- transcription factor , is regulated by PHYTOCHROME-INTERACTING_FACTOR_1 to promote hypocotyl elongation .
20508833	0	Homeodomain-interacting_Protein_Kinase_4	26,66	HIPK4	68,73	Homeodomain-interacting Protein Kinase 4	HIPK3	147746	10114	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of Human Homeodomain-interacting_Protein_Kinase_4 -LRB- HIPK4 -RRB- as a Unique Member of the HIPK Family .
22840522	0	Homeodomain-interacting_protein_kinase	0,38	Yorkie	49,55	Homeodomain-interacting protein kinase	Yorkie	38070(Tax:7227)	37851(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Homeodomain-interacting_protein_kinase regulates Yorkie activity to promote tissue growth .
17960875	0	Homeodomain-interacting_protein_kinase-2	0,40	HMGA1a	64,70	Homeodomain-interacting protein kinase-2	HMGA1a	28996	3159	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Homeodomain-interacting_protein_kinase-2 -LRB- HIPK2 -RRB- phosphorylates HMGA1a at Ser-35 , Thr-52 , and Thr-77 and modulates its DNA binding affinity .
21715331	0	Homeodomain-interacting_protein_kinase-2	0,40	p27	52,55	Homeodomain-interacting protein kinase-2	p27	28996	3429	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Homeodomain-interacting_protein_kinase-2 stabilizes p27 -LRB- kip1 -RRB- by its phosphorylation at serine 10 and contributes to cell motility .
11780126	0	Homeodomain-interacting_protein_kinase-2	0,40	p53	56,59	Homeodomain-interacting protein kinase-2	p53	28996	7157	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Homeodomain-interacting_protein_kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis .
20307497	0	Homeodomain-interacting_protein_kinase_2	0,40	beta-catenin	57,69	Homeodomain-interacting protein kinase 2	beta-catenin	15258(Tax:10090)	12387(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- targets beta-catenin for phosphorylation and proteasomal degradation .
25659434	0	Homeodomain_Interacting_Protein_Kinase_2	97,137	HIPK2	139,144	Homeodomain Interacting Protein Kinase 2	HIPK2	28996	28996	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of Kruppel-like Factor 3 -LRB- KLF3/BKLF -RRB- and C-terminal_Binding_Protein_2 -LRB- CtBP2 -RRB- by Homeodomain_Interacting_Protein_Kinase_2 -LRB- HIPK2 -RRB- Modulates KLF3 DNA Binding and Activity .
26417420	0	Homeodomain_interacting_protein_kinase_2	0,40	peroxisome_proliferator-activated_receptor_gamma	70,118	Homeodomain interacting protein kinase 2	peroxisome proliferator-activated receptor gamma	28996	5468	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|END_ENTITY	Homeodomain_interacting_protein_kinase_2 is downregulated through the peroxisome_proliferator-activated_receptor_gamma signaling pathway in an insulin-resistant population .
24118426	0	Homer1	62,68	Homer2	76,82	Homer1	Homer2	9456	9455	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression : implications for relapse .
19376111	0	Homer1	0,6	TRAIL	39,44	Homer1	TRAIL	9456	8743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Homer1 regulates the susceptibility to TRAIL .
19296124	0	Homer1	66,72	ryanodine_receptor	35,53	Homer1	ryanodine receptor	9456	6261	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	In vitro modulation of the cardiac ryanodine_receptor activity by Homer1 .
12653978	0	Homer1a	68,75	mGluR1	26,32	Homer1a	mGluR1	9456	14799(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons .
24118426	0	Homer2	76,82	Homer1	62,68	Homer2	Homer1	9455	9456	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression : implications for relapse .
18387811	0	Homer2	0,6	amyloid_precursor_protein	32,57	Homer2	amyloid precursor protein	9455	351	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Homer2 and Homer3 interact with amyloid_precursor_protein and inhibit Abeta production .
22445886	0	Homer_1a	17,25	VEGF	0,4	Homer 1a	VEGF	9456	7422	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	VEGF upregulates Homer_1a gene expression via the mitogen-activated protein kinase cascade in cultured cortex neurons .
16786172	0	Homer_1alpha	23,35	Endothelin-1	0,12	Homer 1alpha	Endothelin-1	9456	1906	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Endothelin-1 activates Homer_1alpha expression via mitogen-activated protein kinase in cardiac myocytes .
10644755	0	Homodimer	0,9	IkappaBalpha	64,76	Homodimer	IkappaBalpha	6647	4792	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination .
10644755	0	Homodimer	0,9	betaTrCP1	32,41	Homodimer	betaTrCP1	6647	8945	Gene	Gene	START_ENTITY|nmod|proteins proteins|amod|END_ENTITY	Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination .
15584899	0	Hop	19,22	Aha1	0,4	Hop	Aha1	10963	10598	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Aha1 competes with Hop , p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone_receptor activation .
19325002	0	Hop2	174,178	Tat-binding_protein-1	0,21	Hop2	Tat-binding protein-1	29893	5702	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Tat-binding_protein-1 -LRB- TBP-1 -RRB- , an ATPase of 19S regulatory particles of the 26S proteasome , enhances androgen_receptor function in cooperation with TBP-1-interacting_protein / Hop2 .
22727333	0	Hornerin	0,8	S100	13,17	Hornerin	S100	388697	6285	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Hornerin , an S100 family protein , is functional in breast cells and aberrantly expressed in breast_cancer .
25311085	0	Hotair	52,58	S100_calcium_binding_protein_A4	94,125	Hotair	S100 calcium binding protein A4	100124700	6275	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	Nuclear_factor_of_activated_T_cells_5 maintained by Hotair suppression of miR-568 upregulates S100_calcium_binding_protein_A4 to promote breast_cancer metastasis .
9521915	0	Hox	43,46	AbdA	38,42	Hox	AbdA	42536(Tax:7227)	42037(Tax:7227)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning .
16814723	0	Hox	51,54	Abdominal-B	39,50	Hox	Abdominal-B	42536(Tax:7227)	47763(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution .
26311219	0	Hox	0,3	Bithorax_complex	43,59	Hox	Bithorax complex	42536(Tax:7227)	42034(Tax:7227)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Hox miRNA regulation within the Drosophila Bithorax_complex : Patterning behavior .
10476966	0	Hox	14,17	Caudal	0,6	Hox	Caudal	42536(Tax:7227)	35341(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Caudal is the Hox gene that specifies the most posterior Drosophile segment .
12815073	0	Hox	31,34	GAGA_factor	101,112	Hox	GAGA factor	42536(Tax:7227)	2768981(Tax:7227)	Gene	Gene	START_ENTITY|nmod|interactions interactions|nmod|END_ENTITY	Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA_factor .
22438572	0	Hox	28,31	Pax2	45,49	Hox	Pax2	42536(Tax:7227)	43825(Tax:7227)	Gene	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Integration of an abdominal Hox complex with Pax2 yields cell-specific EGF secretion from Drosophila sensory precursor cells .
16613610	0	Hox	69,72	Scr	65,68	Hox	Scr	42536(Tax:7227)	252583	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene : understanding the role of Enhancers of trithorax and Polycomb .
7555723	0	Hox	8,11	Ultrabithorax	17,30	Hox	Ultrabithorax	42536(Tax:7227)	42034(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nsubj|gene	How the Hox gene Ultrabithorax specifies two different segments : the significance of spatial and temporal regulation within metameres .
19651300	0	Hox	50,53	bithorax_complex	4,20	Hox	bithorax complex	42536(Tax:7227)	42034(Tax:7227)	Gene	Gene	cluster|compound|START_ENTITY Drosophila|dep|cluster END_ENTITY|nmod|Drosophila	The bithorax_complex of Drosophila an exceptional Hox cluster .
10878606	0	Hox	23,26	dlarp	0,5	Hox	dlarp	42536(Tax:7227)	53567(Tax:7227)	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	dlarp , a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions .
10744975	0	Hox	71,74	fushi_tarazu	46,58	Hox	fushi tarazu	42536(Tax:7227)	40834(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Evidence for the derivation of the Drosophila fushi_tarazu gene from a Hox gene orthologous to lophotrochozoan Lox5 .
24885717	0	Hox	49,52	lin-39	58,64	Hox	lin-39	42536(Tax:7227)	176068(Tax:6239)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. _ elegans embryo and larva , including the hypodermal fate regulators LIN-26 and ELT-6 .
15039447	0	Hox	0,3	ultrabithorax	25,38	Hox	ultrabithorax	42536(Tax:7227)	42034(Tax:7227)	Gene	Gene	Ib|compound|START_ENTITY Ib|compound|END_ENTITY	Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected_interacting_protein_1 , a double-stranded RNA-binding protein .
17050628	0	Hox	18,21	ultrabithorax	4,17	Hox	ultrabithorax	42536(Tax:7227)	42034(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway .
21574054	0	Hox-B13	47,54	Keratin_15	0,10	Hox-B13	Keratin 15	10481	3866	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Keratin_15 , transcobalamin_I and homeobox gene Hox-B13 expression in breast_phyllodes_tumors : novel markers in biological classification .
21471217	0	HoxA10	0,6	CDX4	17,21	HoxA10	CDX4	3206	1046	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells .
21471217	0	HoxA10	0,6	HOXA10	55,61	HoxA10	HOXA10	3206	3206	Gene	Gene	transcription|compound|START_ENTITY activates|nsubj|transcription activates|dobj|transcription transcription|nummod|END_ENTITY	HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells .
24177192	0	HoxA9	0,5	Bcl-2	16,21	HoxA9	Bcl-2	3205	596	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia .
25531430	0	HoxA9	41,46	CDX4	14,18	HoxA9	CDX4	3205	1046	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of CDX4 gene transcription by HoxA9 , HoxA10 , the Mll-Ell oncogene and Shp2 during leukemogenesis .
18337761	0	HoxA9	0,5	insulin-like_growth_factor-1_receptor	14,51	HoxA9	insulin-like growth factor-1 receptor	3205	3480	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	HoxA9 induces insulin-like_growth_factor-1_receptor expression in B-lineage acute_lymphoblastic_leukemia .
8093858	0	HoxB2	38,43	Krox20	21,27	HoxB2	Krox20	103889(Tax:10090)	13654(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The zinc finger gene Krox20 regulates HoxB2 -LRB- Hox2 .8 -RRB- during hindbrain segmentation .
16079151	0	HoxB2	0,5	SOD1	19,23	HoxB2	SOD1	103889(Tax:10090)	20655(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS .
23178148	0	HoxC4	32,37	AID	52,55	HoxC4	AID	15423(Tax:10090)	11628(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	APRIL stimulates NF-kB-mediated HoxC4 induction for AID expression in mouse B cells .
7538067	0	Hox_7	56,61	Msx1	50,54	Hox 7	Msx1	17701(Tax:10090)	17701(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Digit tip regeneration correlates with regions of Msx1 -LRB- Hox_7 -RRB- expression in fetal and newborn mice .
26615201	0	Hoxa	41,45	Gm15055	23,30	Hoxa	Gm15055	111336(Tax:10090)	102635415	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The long noncoding RNA Gm15055 represses Hoxa gene expression by recruiting PRC2 to the gene cluster .
17227832	0	Hoxa	30,34	Trib1	0,5	Hoxa	Trib1	111336(Tax:10090)	211770(Tax:10090)	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis .
8625806	0	Hoxa-2	24,30	Krox-20	73,80	Hoxa-2	Krox-20	15399(Tax:10090)	13654(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20 .
9679043	0	Hoxa-4	65,71	IDX-1	52,57	Hoxa-4	IDX-1	15401(Tax:10090)	18609(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum .
25691658	0	Hoxa1	32,37	YAP	0,3	Hoxa1	YAP	15394(Tax:10090)	22601(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues .
26350477	0	Hoxa10	81,87	FoxM1	61,66	Hoxa10	FoxM1	15395(Tax:10090)	14235(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Control of regional decidualization in implantation : Role of FoxM1 downstream of Hoxa10 and cyclin_D3 .
23671666	0	Hoxa2	96,101	Pcp4	51,55	Hoxa2	Pcp4	15399(Tax:10090)	18546(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|distribution distribution|nmod|END_ENTITY	Differential distribution of the Ca -LRB- 2 + -RRB- regulator Pcp4 in the branchial arches is regulated by Hoxa2 .
15634706	0	Hoxa2	0,5	Six2	20,24	Hoxa2	Six2	3199	10736	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme .
9740027	0	Hoxa5	129,134	engrailed-2	87,98	Hoxa5	engrailed-2	15402(Tax:10090)	13799(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Regulation of a Purkinje cell-specific promoter by homeodomain proteins : repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7 .
21925392	0	Hoxa6	36,41	Mistral	18,25	Hoxa6	Mistral	15403(Tax:10090)	100736249	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin .
17384261	0	Hoxa7	61,66	Jpk	0,3	Hoxa7	Jpk	15404(Tax:10090)	11827(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Jpk , a novel cell death inducer , regulates the expression of Hoxa7 in F9 teratocarcinoma cells , but not during apoptosis .
17183676	0	Hoxa9	27,32	Cdx4	0,4	Hoxa9	Cdx4	3205	1046	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells .
20971928	0	Hoxa9	0,5	Flt3	16,20	Hoxa9	Flt3	15405(Tax:10090)	14255(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Hoxa9 regulates Flt3 in lymphohematopoietic progenitors .
21471525	0	Hoxa9	12,17	Smad4	0,5	Hoxa9	Smad4	15405(Tax:10090)	17128(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation .
21320481	0	Hoxb1	27,32	Hoxb3	0,5	Hoxb1	Hoxb3	15407(Tax:10090)	15410(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning .
21320481	0	Hoxb3	0,5	Hoxb1	27,32	Hoxb3	Hoxb1	15410(Tax:10090)	15407(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning .
12855555	0	Hoxb4	26,31	Thrombopoietin	0,14	Hoxb4	Thrombopoietin	15412(Tax:10090)	21832(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Thrombopoietin stimulates Hoxb4 expression : an explanation for the favorable effects of TPO on hematopoietic stem cells .
10617598	0	Hoxb9	103,108	Btg1	32,36	Hoxb9	Btg1	3219	694	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation .
16835220	0	Hoxc13	113,119	Foxq1	41,46	Hoxc13	Foxq1	15422(Tax:10090)	15220(Tax:10090)	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation .
21773674	0	Hoxc8	0,5	Mgl1	20,24	Hoxc8	Mgl1	15426(Tax:10090)	16897(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion .
20016939	0	Hoxc8	0,5	Smad6	42,47	Hoxc8	Smad6	15426(Tax:10090)	17130(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Hoxc8 represses BMP-induced expression of Smad6 .
26311318	0	Hoxd10	53,59	MicroRNA-10b	0,12	Hoxd10	MicroRNA-10b	3236	406903	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-10b promotes migration and invasion through Hoxd10 in human gastric_cancer .
12713442	0	Hpa1	81,85	heparanase	69,79	Hpa1	heparanase	10855	10855	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Biochemical characterization of the active heterodimer form of human heparanase -LRB- Hpa1 -RRB- protein expressed in insect cells .
11027606	0	Hpa2	36,40	heparanase	60,70	Hpa2	heparanase	60495	10855	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Cloning and expression profiling of Hpa2 , a novel mammalian heparanase family member .
7774914	0	Hpd	73,76	4-hydroxyphenylpyruvic_acid_dioxygenase	27,66	Hpd	4-hydroxyphenylpyruvic acid dioxygenase	15445(Tax:10090)	15445(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A nonsense mutation in the 4-hydroxyphenylpyruvic_acid_dioxygenase gene -LRB- Hpd -RRB- causes skipping of the constitutive exon and hypertyrosinemia in mouse_strain III .
2876426	0	Hpr	100,103	haptoglobin-related	79,98	Hpr	haptoglobin-related	3250	3250	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Polymorphisms in the human haptoglobin gene cluster : chromosomes with multiple haptoglobin-related -LRB- Hpr -RRB- genes .
7969137	0	Hprt	117,121	hypoxanthine_phosphoribosyltransferase	77,115	Hprt	hypoxanthine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine_phosphoribosyltransferase -LRB- Hprt -RRB- gene .
20080498	0	Hr	105,107	hairless	90,98	Hr	hairless	15460(Tax:10090)	15460(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular basis for hair loss in mice carrying a novel nonsense mutation -LRB- Hrrh-R -RRB- in the hairless gene -LRB- Hr -RRB- .
16530282	0	Hrb1p	45,50	Sky1p	69,74	Hrb1p	Sky1p	855728(Tax:4932)	855256(Tax:4932)	Gene	Gene	localization|nmod|START_ENTITY independent|nsubj|localization independent|nmod|END_ENTITY	Cellular localization and phosphorylation of Hrb1p is independent of Sky1p .
20886262	0	Hrd1	21,25	alpha_1-antitrypsin	64,83	Hrd1	alpha 1-antitrypsin	84447	5265	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha_1-antitrypsin and increases its solubility .
19835843	0	Hrd1	68,72	gp78	13,17	Hrd1	gp78	74126(Tax:10090)	23802(Tax:10090)	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1 : cross-talk between E3s in the endoplasmic reticulum .
17043138	0	Hrd3p	30,35	SEL1L	0,5	Hrd3p	SEL1L	850904(Tax:4932)	6400	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	SEL1L , the homologue of yeast Hrd3p , is involved in protein dislocation from the mammalian ER .
15781475	0	Hrp59	0,5	hnRNP_M	10,17	Hrp59	hnRNP M	41138(Tax:7227)	41138(Tax:7227)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Hrp59 , an hnRNP_M protein in Chironomus and Drosophila , binds to exonic splicing enhancers and is required for expression of a subset of mRNAs .
23456718	0	Hrq1	0,4	Sgs1	32,36	Hrq1	Sgs1	851885(Tax:4932)	855228(Tax:4932)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Hrq1 functions independently of Sgs1 to preserve genome integrity in Saccharomyces_cerevisiae .
24440721	0	Hrq1	0,4	helicase	35,43	Hrq1	helicase	851885(Tax:4932)	164045	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Hrq1 , a homolog of the human RecQ4 helicase , acts catalytically and structurally to promote genome integrity .
25281559	0	Hrr25	0,5	Atg34	45,50	Hrr25	Atg34	855897(Tax:4932)	854071(Tax:4932)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Hrr25 phosphorylates the autophagic receptor Atg34 to promote vacuolar transport of a-mannosidase under nitrogen starvation conditions .
17062640	0	Hrs	12,15	GRIF1	0,5	Hrs	GRIF1	9146	66008	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	GRIF1 binds Hrs and is a new regulator of endosomal trafficking .
10825299	0	Hrs	0,3	SNAP-25	19,26	Hrs	SNAP-25	56084(Tax:10116)	25012(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hrs interacts with SNAP-25 and regulates Ca -LRB- 2 + -RRB- - dependent exocytosis .
11110793	0	Hrs	0,3	sorting_nexin_1	19,34	Hrs	sorting nexin 1	9146	6642	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hrs interacts with sorting_nexin_1 and regulates degradation of epidermal_growth_factor_receptor .
10385629	0	Hrt1	31,35	SCF	55,58	Hrt1	SCF	9978	4254	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34 .
25119594	0	Hsa-miR-195	0,11	PCMT1	20,25	Hsa-miR-195	PCMT1	406971	5110	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Hsa-miR-195 targets PCMT1 in hepatocellular_carcinoma that increases_tumor life span .
26840018	0	Hsa-miR-326	0,11	CCND1	20,25	Hsa-miR-326	CCND1	442900	595	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Hsa-miR-326 targets CCND1 and inhibits non-small_cell_lung_cancer development .
24600991	0	Hsa-mir-182	0,11	RASA1	26,31	Hsa-mir-182	RASA1	406958	5921	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Hsa-mir-182 downregulates RASA1 and suppresses lung_squamous_cell_carcinoma cell proliferation .
17878160	0	Hsc70	31,36	ASIC2	85,90	Hsc70	ASIC2	3312	40	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cells .
18310515	0	Hsc70	0,5	ASIC2	29,34	Hsc70	ASIC2	3312	40	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|expression expression|compound|END_ENTITY	Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration .
24122553	0	Hsc70	34,39	DNAJC12	17,24	Hsc70	DNAJC12	3312	56521	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The co-chaperone DNAJC12 binds to Hsc70 and is upregulated by endoplasmic reticulum stress .
15292236	0	Hsc70	23,28	Hsp105alpha	0,11	Hsc70	Hsp105alpha	3312	10808	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity .
10898246	0	Hsc70	88,93	Hsp70	27,32	Hsc70	Hsp70	24468(Tax:10116)	266759(Tax:10116)	Gene	Gene	Hsp70|appos|START_ENTITY expressed|dobj|Hsp70 expressed|ccomp|Increase Increase|nmod|level level|nmod|END_ENTITY	Increase in basal level of Hsp70 , consisting chiefly of constitutively expressed Hsp70 -LRB- Hsc70 -RRB- in aged rat brain .
18841484	0	Hsc70	43,48	Hsp70	0,5	Hsc70	Hsp70	15481(Tax:10090)	15511(Tax:10090)	Gene	Gene	localizes|nmod|START_ENTITY localizes|nsubj|END_ENTITY	Hsp70 localizes differently from chaperone Hsc70 in mouse mesoangioblasts under physiological growth conditions .
12417338	0	Hsc70	63,68	HspBP1	0,6	Hsc70	HspBP1	3312	23640	Gene	Gene	factor|amod|START_ENTITY factor|nsubj|END_ENTITY	HspBP1 , a homologue of the yeast Fes1 and Sls1 proteins , is an Hsc70 nucleotide exchange factor .
15051737	0	Hsc70	42,47	Rme-8	21,26	Hsc70	Rme-8	39542(Tax:7227)	35939(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila .
21832061	0	Hsc70	0,5	alpha-synuclein	53,68	Hsc70	alpha-synuclein	3312	6622	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Hsc70 protein interaction with soluble and fibrillar alpha-synuclein .
19457116	0	Hsc70	24,29	vesicular_monoamine_transporter-2	49,82	Hsc70	vesicular monoamine transporter-2	3312	6571	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The molecular chaperone Hsc70 interacts with the vesicular_monoamine_transporter-2 .
10092118	0	Hsc70t	24,30	Hsp70	4,9	Hsc70t	Hsp70	15482(Tax:10090)	15511(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Hsp70 homolog gene , Hsc70t , is expressed under translational control during mouse spermiogenesis .
18669642	0	Hsd17b7	87,94	Prolactin_receptor-associated_protein	0,37	Hsd17b7	Prolactin receptor-associated protein	15490(Tax:10090)	20200(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prolactin_receptor-associated_protein / 17beta-hydroxysteroid dehydrogenase type 7 gene -LRB- Hsd17b7 -RRB- plays a crucial role in embryonic development and fetal survival .
18474607	0	Hsf-1	0,5	Ralbp1	67,73	Hsf-1	Ralbp1	3297	10928	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|END_ENTITY	Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1 .
10490630	0	Hsl1p	101,106	Swe1p	80,85	Hsl1p	Swe1p	853760(Tax:4932)	853252(Tax:4932)	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	The morphogenesis checkpoint in Saccharomyces_cerevisiae : cell cycle control of Swe1p degradation by Hsl1p and Hsl7p .
10903903	0	Hsl7p	0,5	JBP1	36,40	Hsl7p	JBP1	852431(Tax:4932)	10419	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Hsl7p , the yeast homologue of human JBP1 , is a protein methyltransferase .
8948438	0	Hsp-70	0,6	transferrin_receptor	38,58	Hsp-70	transferrin receptor	3308	7037	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Hsp-70 is closely associated with the transferrin_receptor in exosomes from maturing reticulocytes .
16995899	0	Hsp101	36,42	APG6	54,58	Hsp101	APG6	843771(Tax:3702)	831398(Tax:3702)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	An Arabidopsis chloroplast-targeted Hsp101 homologue , APG6 , has an essential role in chloroplast development as well as heat-stress response .
14507919	0	Hsp104	79,85	Sup35	50,55	Hsp104	Sup35	850633(Tax:4932)	851752(Tax:4932)	Gene	Gene	fragmented|nmod|START_ENTITY polymers|acl|fragmented polymers|amod|END_ENTITY	Yeast -LSB- PSI + -RSB- prion aggregates are formed by small Sup35 polymers fragmented by Hsp104 .
15155912	0	Hsp104	0,6	Sup35	63,68	Hsp104	Sup35	850633(Tax:4932)	851752(Tax:4932)	Gene	Gene	catalyzes|nsubj|START_ENTITY catalyzes|dobj|formation formation|nmod|conformers conformers|amod|END_ENTITY	Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers .
15448141	0	Hsp104	0,6	Sup35	22,27	Hsp104	Sup35	850633(Tax:4932)	851752(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|fiber fiber|nummod|END_ENTITY	Hsp104 binds to yeast Sup35 prion fiber but needs other factor -LRB- s -RRB- to sever it .
18833196	0	Hsp104	0,6	Sup35	81,86	Hsp104	Sup35	850633(Tax:4932)	851752(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|formation formation|nmod|prions prions|amod|END_ENTITY	Hsp104 , Hsp70 and Hsp40 interplay regulates formation , growth and elimination of Sup35 prions .
24216111	0	Hsp104	19,25	Sup35	43,48	Hsp104	Sup35	850633(Tax:4932)	851752(Tax:4932)	Gene	Gene	interaction|nmod|START_ENTITY analyzed|nsubj|interaction analyzed|advmod|as as|nmod:npmod|END_ENTITY	The interaction of Hsp104 with yeast prion Sup35 as analyzed by fluorescence cross-correlation spectroscopy .
9391130	0	Hsp104	30,36	Sup35	48,53	Hsp104	Sup35	850633(Tax:4932)	851752(Tax:4932)	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP .
15292236	0	Hsp105alpha	0,11	Hsc70	23,28	Hsp105alpha	Hsc70	10808	3312	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|amod|END_ENTITY	Hsp105alpha suppresses Hsc70 chaperone activity by inhibiting Hsc70 ATPase activity .
25088258	0	Hsp105b	19,26	Nmi	0,3	Hsp105b	Nmi	10808	9111	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nmi interacts with Hsp105b and enhances the Hsp105b-mediated Hsp70 expression .
19754877	0	Hsp105beta	0,10	hsp70	23,28	Hsp105beta	hsp70	10808	3308	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Hsp105beta upregulates hsp70 gene expression through signal_transducer_and_activator_of_transcription-3 .
22731613	0	Hsp20	92,97	AKAP-Lbc	31,39	Hsp20	AKAP-Lbc	126393	11214	Gene	Gene	phosphorylation|nmod|START_ENTITY facilitates|dobj|phosphorylation facilitates|nsubj|END_ENTITY	The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser -LRB- 16 -RRB- .
21526341	0	Hsp22	57,62	HspB8	50,55	Hsp22	HspB8	26353	26353	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of human small heat shock protein HspB8 -LRB- Hsp22 -RRB- by ERK1 protein kinase .
21767525	0	Hsp22	64,69	HspB8	57,62	Hsp22	HspB8	26353	26353	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization of small heat_shock protein HspB8 -LRB- Hsp22 -RRB- - Bag3 interaction .
12038984	0	Hsp25	0,5	p21	34,37	Hsp25	p21	15507(Tax:10090)	12575(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Hsp25 regulates the expression of p21 -LRB- Waf1/Cip1/Sdi1 -RRB- through multiple mechanisms .
15843375	1	Hsp26	74,79	Ssa1	85,89	Hsp26	Ssa1	852364(Tax:4932)	851259(Tax:4932)	Gene	Gene	cooperation|nmod|START_ENTITY cooperation|nmod|END_ENTITY	The cooperation of Hsp26 with Ssa1 and Hsp104 .
25200832	0	Hsp27	49,54	AKT	19,22	Hsp27	AKT	3315	207	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Phosphorylation of AKT induced by phosphorylated Hsp27 confers the apoptosis-resistance in t-AUCB-treated glioblastoma cells in vitro .
17606386	0	Hsp27	66,71	ATF5	0,4	Hsp27	ATF5	3315	22809	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	ATF5 promotes cell survival through transcriptional activation of Hsp27 in H9c2 cells .
17510053	0	Hsp27	0,5	Akt	16,19	Hsp27	Akt	3315	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex .
17510053	0	Hsp27	0,5	Akt	95,98	Hsp27	Akt	3315	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|scaffolding scaffolding|xcomp|END_ENTITY	Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex .
20858736	0	Hsp27	0,5	Akt	65,68	Hsp27	Akt	3315	207	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|nmod|END_ENTITY	Hsp27 protects adenocarcinoma cells from UV-induced apoptosis by Akt and p21-dependent pathways of survival .
22222935	0	Hsp27	26,31	HSPB1	33,38	Hsp27	HSPB1	3315	3315	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Plasma Hsp72 -LRB- HSPA1A -RRB- and Hsp27 -LRB- HSPB1 -RRB- expression under heat stress : influence of exercise intensity .
10049695	0	Hsp27	28,33	Hsp27	47,52	Hsp27	Hsp27	24471(Tax:10116)	24471(Tax:10116)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Identification of a site of Hsp27 binding with Hsp27 and alpha_B-crystallin as indicated by the yeast two-hybrid system .
10049695	0	Hsp27	47,52	Hsp27	28,33	Hsp27	Hsp27	24471(Tax:10116)	24471(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Identification of a site of Hsp27 binding with Hsp27 and alpha_B-crystallin as indicated by the yeast two-hybrid system .
17080460	0	Hsp27	47,52	Hsp70	54,59	Hsp27	Hsp70	3315	3308	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of 50 Hz sinusoidal magnetic fields on Hsp27 , Hsp70 , Hsp90 expression in porcine aortic endothelial cells -LRB- PAEC -RRB- .
17080460	0	Hsp27	47,52	Hsp90	61,66	Hsp27	Hsp90	3315	3320	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of 50 Hz sinusoidal magnetic fields on Hsp27 , Hsp70 , Hsp90 expression in porcine aortic endothelial cells -LRB- PAEC -RRB- .
25583479	0	Hsp27	54,59	Hsp90	67,72	Hsp27	Hsp90	3315	3320	Gene	Gene	recruits|dobj|START_ENTITY recruits|nmod|complex complex|amod|END_ENTITY	Mutant glucocerebrosidase in Gaucher_disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation .
18497994	0	Hsp27	25,30	IFN-gamma	0,9	Hsp27	IFN-gamma	3315	3458	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	IFN-gamma down-regulates Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo .
12700631	0	Hsp27	31,36	Interferon-gamma	0,16	Hsp27	Interferon-gamma	3315	3458	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral_squamous_cell_carcinoma lines .
16126176	0	Hsp27	22,27	ataxin-3	54,62	Hsp27	ataxin-3	3315	4287	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Dynamic expression of Hsp27 in the presence of mutant ataxin-3 .
15649417	0	Hsp27	0,5	cytochrome_c	41,53	Hsp27	cytochrome c	24471(Tax:10116)	54205	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Hsp27 inhibits 6-hydroxydopamine-induced cytochrome_c release and apoptosis in PC12 cells .
17185631	0	Hsp27	13,18	fMLP	0,4	Hsp27	fMLP	3315	2357	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	fMLP induces Hsp27 expression , attenuates NF-kappaB activation , and confers intestinal epithelial cell protection .
12226095	0	Hsp27	37,42	heat-shock_protein_27	14,35	Hsp27	heat-shock protein 27	3315	3315	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Modulation of heat-shock_protein_27 -LRB- Hsp27 -RRB- anti-apoptotic activity by methylglyoxal modification .
9219918	0	Hsp27	47,52	heat_shock_estrogen_receptor-associated_protein	53,100	Hsp27	heat shock estrogen receptor-associated protein	3315	3315	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Lack of relationship between the expression of Hsp27 heat_shock_estrogen_receptor-associated_protein and estrogen receptor or progesterone receptor status in male_breast_carcinoma .
19322656	0	Hsp27	56,61	heat_shock_protein_27	33,54	Hsp27	heat shock protein 27	3315	3315	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of small heat_shock_protein_27 -LRB- Hsp27 -RRB- in Ataxia_telangiectasia brains .
17906111	0	Hsp27	107,112	p38	79,82	Hsp27	p38	24471(Tax:10116)	81649(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27 .
18089808	0	Hsp27	0,5	p53	16,19	Hsp27	p53	3315	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Hsp27 modulates p53 signaling and suppresses cellular senescence .
20587688	0	Hsp27	125,130	p53	81,84	Hsp27	p53	3315	7157	Gene	Gene	proteins|dep|START_ENTITY proteins|dep|END_ENTITY	Canine gastric_carcinoma : immunohistochemical expression of cell cycle proteins -LRB- p53 , p21 , and p16 -RRB- and heat_shock proteins -LRB- Hsp27 and Hsp70 -RRB- .
23357534	0	Hsp27	15,20	p53	45,48	Hsp27	p53	3315	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis .
10803458	0	Hsp27	0,5	procaspase-3	80,92	Hsp27	procaspase-3	3315	836	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Hsp27 functions as a negative regulator of cytochrome_c-dependent activation of procaspase-3 .
24323422	0	Hsp32	67,72	Hsp70	42,47	Hsp32	Hsp70	3162	3308	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Heat_shock proteins in the brain : role of Hsp70 , Hsp_27 , and HO-1 -LRB- Hsp32 -RRB- and their therapeutic potential .
23408083	0	Hsp40	6,11	DNAJA1	22,28	Hsp40	DNAJA1	171221	3301	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Human Hsp40 proteins , DNAJA1 and DNAJA2 , as potential targets of the immune response triggered by bacterial DnaJ in rheumatoid_arthritis .
8975727	0	Hsp40	50,55	HSPF1	63,68	Hsp40	HSPF1	3337	3337	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic cloning of a human heat_shock protein 40 -LRB- Hsp40 -RRB- gene -LRB- HSPF1 -RRB- and its chromosomal localization to 19p13 .2 .
20809635	0	Hsp40	73,78	Hdj1	79,83	Hsp40	Hdj1	3337	3337	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70 .
14503850	0	Hsp40	27,32	Hsp70	47,52	Hsp40	Hsp70	171221	3308	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation .
15115283	0	Hsp40	47,52	Hsp70	29,34	Hsp40	Hsp70	171221	3308	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Mechanisms Mechanisms|nmod|regulation regulation|nmod|END_ENTITY	Mechanisms for regulation of Hsp70 function by Hsp40 .
19359181	0	Hsp40	26,31	Hsp70	35,40	Hsp40	Hsp70	3337	3308	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|chaperones chaperones|amod|END_ENTITY	Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones .
19718689	0	Hsp40	109,114	Hsp70	30,35	Hsp40	Hsp70	171221	3308	Gene	Gene	co-chaperone|amod|START_ENTITY requires|dobj|co-chaperone requires|nsubj|affinity affinity|nmod|END_ENTITY	High affinity binding between Hsp70 and the C-terminal domain of the measles_virus nucleoprotein requires an Hsp40 co-chaperone .
19748898	0	Hsp40	14,19	Hsp70	39,44	Hsp40	Hsp70	171221	3308	Gene	Gene	ERdj3|amod|START_ENTITY requires|nsubj|ERdj3 requires|dobj|interaction interaction|amod|END_ENTITY	The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions .
20809635	0	Hsp40	73,78	Hsp70	145,150	Hsp40	Hsp70	3337	3308	Gene	Gene	domain|compound|START_ENTITY structures|nmod|domain revealed|nmod|structures revealed|nmod|octapeptide octapeptide|nmod|END_ENTITY	Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70 .
15472720	0	Hsp40	43,48	Ydj1	49,53	Hsp40	Ydj1	855661(Tax:4932)	855661(Tax:4932)	Gene	Gene	identification|nmod|START_ENTITY END_ENTITY|nsubj|identification	Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library .
23587601	0	Hsp47	59,64	TRAIL	0,5	Hsp47	TRAIL	871	8743	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	TRAIL regulates collagen production through HSF1-dependent Hsp47 expression in activated hepatic stellate cells .
23807299	0	Hsp60	105,110	Hsp60	40,45	Hsp60	Hsp60	3329	3329	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain_tumors and putative role of Hsp60 in neuroepithelial tumorigenesis .
23807299	0	Hsp60	40,45	Hsp60	105,110	Hsp60	Hsp60	3329	3329	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain_tumors and putative role of Hsp60 in neuroepithelial tumorigenesis .
21769504	0	Hsp60	32,37	THP-1	47,52	Hsp60	THP-1	3329	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Metformin induced expression of Hsp60 in human THP-1 monocyte cells .
10653585	0	Hsp60	67,72	heat_shock_chaperonin_protein	36,65	Hsp60	heat shock chaperonin protein	3329	3329	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of mitochondrial 60-kD heat_shock_chaperonin_protein -LRB- Hsp60 -RRB- in pituitary growth_hormone secretory granules and pancreatic zymogen granules .
17588138	0	Hsp60	37,42	heat_shock_protein_60	14,35	Hsp60	heat shock protein 60	3329	3329	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Extracellular heat_shock_protein_60 -LRB- Hsp60 -RRB- levels in children with septic_shock .
20655308	0	Hsp60	23,28	miR-1	0,5	Hsp60	miR-1	3329	79187	Gene	Gene	expression|amod|START_ENTITY contributing|nsubj|expression END_ENTITY|appos|contributing	miR-1 / miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes .
20655308	0	Hsp60	23,28	miR-206	6,13	Hsp60	miR-206	3329	406989	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	miR-1 / miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes .
18657319	0	Hsp70	76,81	ATPase	31,37	Hsp70	ATPase	3308	1769	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Distinct binding sites for the ATPase and substrate-binding domain of human Hsp70 on the cell surface of antigen_presenting_cells .
16397188	0	Hsp70	179,184	Apaf-1	100,106	Hsp70	Apaf-1	15511(Tax:10090)	11783(Tax:10090)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Reduction of caspase-8_and _ -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic _ injury in mice overexpressing Hsp70 .
16245362	0	Hsp70	23,28	CD4	78,81	Hsp70	CD4	3308	920	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	The heat_shock protein Hsp70 enhances antigen-specific proliferation of human CD4 + memory T cells .
21170379	0	Hsp70	58,63	CD4	80,83	Hsp70	CD4	15511(Tax:10090)	12504(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY allografts|acl|induced survival|nmod|allografts dependent|nsubj|survival dependent|nmod|cells cells|compound|END_ENTITY	Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4 + CD25 + regulatory T cells .
27014269	0	Hsp70	125,130	CD4	50,53	Hsp70	CD4	15511(Tax:10090)	12504(Tax:10090)	Gene	Gene	Peptide|compound|START_ENTITY Recognizing|dobj|Peptide Cells|xcomp|Recognizing Cells|nsubj|Generation Generation|nmod|Mouse Mouse|nmod|T T|compound|END_ENTITY	Generation of the First TCR Transgenic Mouse with CD4 -LRB- + -RRB- T Cells Recognizing an Anti-inflammatory Regulatory T Cell-Inducing Hsp70 Peptide .
22824801	0	Hsp70	30,35	CHIP	91,95	Hsp70	CHIP	3308	358	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances .
24843029	0	Hsp70	97,102	ClpB	62,66	Hsp70	ClpB	3308	81570	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein_disaggregation .
21325828	0	Hsp70	92,97	ERK2	22,26	Hsp70	ERK2	15511(Tax:10090)	26413(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role for ERK2 in anoxia-induced activation of transcription and translation of Hsp70 in NIH 3T3 cells .
11500375	0	Hsp70	21,26	FANCC	0,5	Hsp70	FANCC	3308	2176	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity .
18052042	0	Hsp70	59,64	Harc	39,43	Hsp70	Harc	3308	55664	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|nmod|binding	Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat_shock .
20809635	0	Hsp70	145,150	Hdj1	79,83	Hsp70	Hdj1	3308	3337	Gene	Gene	octapeptide|nmod|START_ENTITY revealed|nmod|octapeptide revealed|nmod|structures structures|nmod|domain domain|compound|END_ENTITY	Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70 .
18840778	0	Hsp70	23,28	Heat-shock_protein_70	0,21	Hsp70	Heat-shock protein 70	3308	3308	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Heat-shock_protein_70 -LRB- Hsp70 -RRB- expression in four limpets of the genus Lottia : interspecific variation in constitutive and inducible synthesis correlates with in situ exposure to heat stress .
24312699	0	Hsp70	49,54	Heat_Shock_Protein_70	26,47	Hsp70	Heat Shock Protein 70	3308	3308	Gene	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Analogs of the Allosteric Heat_Shock_Protein_70 -LRB- Hsp70 -RRB- Inhibitor , MKT-077 , as Anti-Cancer Agents .
25484218	0	Hsp70	116,121	Hikeshi	70,77	Hsp70	Hikeshi	3308	51501	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Crystallization and preliminary X-ray crystallographic study of human Hikeshi , a new nuclear transport receptor for Hsp70 .
10898246	0	Hsp70	27,32	Hsc70	88,93	Hsp70	Hsc70	266759(Tax:10116)	24468(Tax:10116)	Gene	Gene	level|nmod|START_ENTITY Increase|nmod|level expressed|ccomp|Increase expressed|dobj|Hsp70 Hsp70|appos|END_ENTITY	Increase in basal level of Hsp70 , consisting chiefly of constitutively expressed Hsp70 -LRB- Hsc70 -RRB- in aged rat brain .
18841484	0	Hsp70	0,5	Hsc70	43,48	Hsp70	Hsc70	15511(Tax:10090)	15481(Tax:10090)	Gene	Gene	localizes|nsubj|START_ENTITY localizes|nmod|END_ENTITY	Hsp70 localizes differently from chaperone Hsc70 in mouse mesoangioblasts under physiological growth conditions .
10092118	0	Hsp70	4,9	Hsc70t	24,30	Hsp70	Hsc70t	15511(Tax:10090)	15482(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Hsp70 homolog gene , Hsc70t , is expressed under translational control during mouse spermiogenesis .
17080460	0	Hsp70	54,59	Hsp27	47,52	Hsp70	Hsp27	3308	3315	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of 50 Hz sinusoidal magnetic fields on Hsp27 , Hsp70 , Hsp90 expression in porcine aortic endothelial cells -LRB- PAEC -RRB- .
24323422	0	Hsp70	42,47	Hsp32	67,72	Hsp70	Hsp32	3308	3162	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Heat_shock proteins in the brain : role of Hsp70 , Hsp_27 , and HO-1 -LRB- Hsp32 -RRB- and their therapeutic potential .
14503850	0	Hsp70	47,52	Hsp40	27,32	Hsp70	Hsp40	3308	171221	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation .
15115283	0	Hsp70	29,34	Hsp40	47,52	Hsp70	Hsp40	3308	171221	Gene	Gene	regulation|nmod|START_ENTITY Mechanisms|nmod|regulation function|nsubj|Mechanisms function|nmod|END_ENTITY	Mechanisms for regulation of Hsp70 function by Hsp40 .
19359181	0	Hsp70	35,40	Hsp40	26,31	Hsp70	Hsp40	3308	3337	Gene	Gene	chaperones|amod|START_ENTITY transfer|nmod|chaperones transfer|nmod|END_ENTITY	Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones .
19718689	0	Hsp70	30,35	Hsp40	109,114	Hsp70	Hsp40	3308	171221	Gene	Gene	affinity|nmod|START_ENTITY requires|nsubj|affinity requires|dobj|co-chaperone co-chaperone|amod|END_ENTITY	High affinity binding between Hsp70 and the C-terminal domain of the measles_virus nucleoprotein requires an Hsp40 co-chaperone .
19748898	0	Hsp70	39,44	Hsp40	14,19	Hsp70	Hsp40	3308	171221	Gene	Gene	interaction|amod|START_ENTITY requires|dobj|interaction requires|nsubj|ERdj3 ERdj3|amod|END_ENTITY	The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions .
20809635	0	Hsp70	145,150	Hsp40	73,78	Hsp70	Hsp40	3308	3337	Gene	Gene	octapeptide|nmod|START_ENTITY revealed|nmod|octapeptide revealed|nmod|structures structures|nmod|domain domain|compound|END_ENTITY	Peptide-binding sites as revealed by the crystal structures of the human Hsp40 Hdj1 C-terminal domain in complex with the octapeptide from human Hsp70 .
10945351	0	Hsp70	101,106	Hsp70	31,36	Hsp70	Hsp70	542111(Tax:4577)	542111(Tax:4577)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the maize cytosolic Hsp70 to calmodulin , and identification of calmodulin-binding site in Hsp70 .
10945351	0	Hsp70	31,36	Hsp70	101,106	Hsp70	Hsp70	542111(Tax:4577)	542111(Tax:4577)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the maize cytosolic Hsp70 to calmodulin , and identification of calmodulin-binding site in Hsp70 .
16953115	0	Hsp70	34,39	Hsp70	74,79	Hsp70	Hsp70	3308	3308	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of heat_shock_protein_70 -LRB- Hsp70 -RRB- and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells .
16953115	0	Hsp70	74,79	Hsp70	34,39	Hsp70	Hsp70	3308	3308	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of heat_shock_protein_70 -LRB- Hsp70 -RRB- and the effects of extracellular Hsp70 on matric metalloproteinase-9 expression in human monocytic U937 cells .
19672680	0	Hsp70	0,5	Hsp70	108,113	Hsp70	Hsp70	3308	3308	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Hsp70 expression in monocytes from patients with peripheral_arterial_disease and healthy controls : monocyte Hsp70 in PAD .
19672680	0	Hsp70	108,113	Hsp70	0,5	Hsp70	Hsp70	3308	3308	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Hsp70 expression in monocytes from patients with peripheral_arterial_disease and healthy controls : monocyte Hsp70 in PAD .
11877417	1	Hsp70	87,92	Hsp90	101,106	Hsp70	Hsp90	3308	3320	Gene	Gene	EEVD-recognition|nmod|START_ENTITY Relevance|nmod|EEVD-recognition Hop|nsubj|Relevance Hop|dobj|complexes complexes|amod|END_ENTITY	Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes .
12459260	0	Hsp70	101,106	Hsp90	41,46	Hsp70	Hsp90	3308	3320	Gene	Gene	reveal|nmod|START_ENTITY homologs|xcomp|reveal homologs|nsubj|relationships relationships|nmod|END_ENTITY	Phylogenetic relationships of organellar Hsp90 homologs reveal fundamental differences to organellar Hsp70 and Hsp60 evolution .
17080460	0	Hsp70	54,59	Hsp90	61,66	Hsp70	Hsp90	3308	3320	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of 50 Hz sinusoidal magnetic fields on Hsp27 , Hsp70 , Hsp90 expression in porcine aortic endothelial cells -LRB- PAEC -RRB- .
17397803	0	Hsp70	78,83	Hsp90	15,20	Hsp70	Hsp90	3308	3320	Gene	Gene	hyperacetylation|nmod|START_ENTITY cells|nmod|hyperacetylation function|nmod|cells function|amod|END_ENTITY	FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70 .
19747088	0	Hsp70	49,54	Hsp90	87,92	Hsp70	Hsp90	3308	3320	Gene	Gene	use|nmod|START_ENTITY investigation|nmod|use biomarker|nsubj|investigation biomarker|nmod|inhibitors inhibitors|amod|END_ENTITY	An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors .
23583203	0	Hsp70	0,5	Hsp90	98,103	Hsp70	Hsp90	3308	3320	Gene	Gene	silencing|amod|START_ENTITY enhances|nsubj|silencing enhances|dobj|death death|acl|induced induced|nmod|inhibitor inhibitor|nmod|END_ENTITY	Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90 .
25679754	0	Hsp70	13,18	Hsp90	61,66	Hsp70	Hsp90	3308	3320	Gene	Gene	inhibitor|amod|START_ENTITY Combining|dobj|inhibitor Combining|nmod|inhibitor inhibitor|amod|END_ENTITY	Combining an Hsp70 inhibitor with either an N - or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes .
26565746	0	Hsp70	80,85	Hsp90	114,119	Hsp70	Hsp90	3308	3320	Gene	Gene	Protein|appos|START_ENTITY Protein|appos|END_ENTITY	Specific Binding of Tetratricopeptide Repeat Proteins to Heat_Shock Protein 70 -LRB- Hsp70 -RRB- and Heat_Shock Protein 90 -LRB- Hsp90 -RRB- Is Regulated by Affinity and Phosphorylation .
15198984	0	Hsp70	0,5	IKK_gamma	49,58	Hsp70	IKK gamma	3308	8517	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Hsp70 promotes TNF-mediated apoptosis by binding IKK_gamma and impairing NF-kappa_B survival signaling .
23808579	0	Hsp70	14,19	IL-10	69,74	Hsp70	IL-10	15511(Tax:10090)	16153(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Extracellular Hsp70 inhibits pro-inflammatory cytokine production by IL-10 driven down-regulation of C/EBPb and C/EBP .
9821948	0	Hsp70	8,13	JNK	45,48	Hsp70	JNK	3308	5599	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of Hsp70 in regulation of stress-kinase JNK : implications in apoptosis and aging .
20964628	0	Hsp70	0,5	PrPC	15,19	Hsp70	PrPC	3308	5621	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Hsp70 binds to PrPC in the process of PrPC release via exosomes from THP-1 monocytes .
20964628	0	Hsp70	0,5	PrPC	38,42	Hsp70	PrPC	3308	5621	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|process process|nmod|release release|amod|END_ENTITY	Hsp70 binds to PrPC in the process of PrPC release via exosomes from THP-1 monocytes .
18172893	0	Hsp70	110,115	ROS	89,92	Hsp70	ROS	44920(Tax:7227)	44175	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Adverse effect of tannery waste leachates in transgenic Drosophila_melanogaster : role of ROS in modulation of Hsp70 , oxidative stress and apoptosis .
17466273	0	Hsp70	0,5	Sgt1	25,29	Hsp70	Sgt1	3308	10910	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Hsp70 is a new target of Sgt1 -- an interaction modulated by S100A6 .
24613385	0	Hsp70	0,5	TGF-b	36,41	Hsp70	TGF-b	3308	7040	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Hsp70 and Hsp90 oppositely regulate TGF-b signaling through CHIP/Stub1 .
19995547	0	Hsp70	62,67	TGF-beta	22,30	Hsp70	TGF-beta	3308	7040	Gene	Gene	induction|nmod|START_ENTITY signaling|nmod|induction END_ENTITY|acl|signaling	Geldanamycin inhibits TGF-beta signaling through induction of Hsp70 .
19811405	0	Hsp70	11,16	Th1	42,45	Hsp70	Th1	15511(Tax:10090)	57314(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|responses responses|amod|END_ENTITY	Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell_lymphoma .
1506415	0	Hsp70	50,55	Transforming_growth_factor-beta_1	0,33	Hsp70	Transforming growth factor-beta 1	423504(Tax:9031)	100873157	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 rapidly induces Hsp70 and Hsp90 molecular chaperones in cultured chicken embryo cells .
15451558	0	Hsp70	97,102	cytochrome_P450_1A2	29,48	Hsp70	cytochrome P450 1A2	3308	1544	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of human cytochrome_P450_1A2 by co-expression with human molecular chaperone Hsp70 .
15576310	0	Hsp70	45,50	heat-shock_protein_70	22,43	Hsp70	heat-shock protein 70	3308	3308	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Exercise raises serum heat-shock_protein_70 -LRB- Hsp70 -RRB- levels .
12489113	0	Hsp70	34,39	heat_shock_protein_70	11,32	Hsp70	heat shock protein 70	3308	3308	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of heat_shock_protein_70 -LRB- Hsp70 -RRB- on arsenite-induced genotoxicity .
12530536	0	Hsp70	90,95	heat_shock_protein_70	67,88	Hsp70	heat shock protein 70	3308	3308	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Effects of antineoplastic agents on cytoplasmic and membrane-bound heat_shock_protein_70 -LRB- Hsp70 -RRB- levels .
18347936	0	Hsp70	87,92	heat_shock_protein_70	64,85	Hsp70	heat shock protein 70	3308	3308	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The therapeutic implications of clinically applied modifiers of heat_shock_protein_70 -LRB- Hsp70 -RRB- expression by tumor cells .
20734248	0	Hsp70	67,72	heat_shock_protein_70	44,65	Hsp70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	The Nrf2-Keap1 cellular defense pathway and heat_shock_protein_70 -LRB- Hsp70 -RRB- response .
22322648	0	Hsp70	112,117	heat_shock_protein_70	89,110	Hsp70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tonicity_enhancer_binding_protein -LRB- TonEBP -RRB- and hypoxia-inducible factor -LRB- HIF -RRB- coordinate heat_shock_protein_70 -LRB- Hsp70 -RRB- expression in hypoxic nucleus pulposus cells : role of Hsp70 in HIF-1a degradation .
22322648	0	Hsp70	173,178	heat_shock_protein_70	89,110	Hsp70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Tonicity_enhancer_binding_protein -LRB- TonEBP -RRB- and hypoxia-inducible factor -LRB- HIF -RRB- coordinate heat_shock_protein_70 -LRB- Hsp70 -RRB- expression in hypoxic nucleus pulposus cells : role of Hsp70 in HIF-1a degradation .
22933182	0	Hsp70	127,132	heat_shock_protein_70	104,125	Hsp70	heat shock protein 70	3308	3308	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat_shock_protein_70 -LRB- Hsp70 -RRB- levels .
24890362	0	Hsp70	48,53	heat_shock_protein_70	25,46	Hsp70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The protective effect of heat_shock_protein_70 -LRB- Hsp70 -RRB- in atrial_fibrillation in various cardiomyopathy conditions .
25681671	0	Hsp70	35,40	heat_shock_protein_70	12,33	Hsp70	heat shock protein 70	3308	3308	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of heat_shock_protein_70 -LRB- Hsp70 -RRB- in radiation-induced immunomodulation .
9774392	0	Hsp70	28,33	hsp40	68,73	Hsp70	hsp40	3308	3337	Gene	Gene	activity|nmod|START_ENTITY modified|nsubjpass|activity modified|nmod|Sis1 Sis1|amod|END_ENTITY	Protein folding activity of Hsp70 is modified differentially by the hsp40 co-chaperones Sis1 and Ydj1 .
16790501	0	Hsp70	125,130	p38	93,96	Hsp70	p38	3308	1432	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27 .
19749793	0	Hsp70	0,5	p53	51,54	Hsp70	p53	3308	7157	Gene	Gene	chaperones|amod|START_ENTITY required|nsubjpass|chaperones required|xcomp|support support|dobj|activity activity|compound|END_ENTITY	Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions .
20153329	0	Hsp70	36,41	p53	53,56	Hsp70	p53	3308	7157	Gene	Gene	Reconstitution|nmod|START_ENTITY Reconstitution|dep|interaction interaction|compound|END_ENTITY	Reconstitution of the mitochondrial Hsp70 -LRB- mortalin -RRB- - p53 interaction using purified proteins -- identification of additional interacting regions .
22933182	0	Hsp70	127,132	p53	31,34	Hsp70	p53	3308	7157	Gene	Gene	levels|appos|START_ENTITY associated|nmod|levels associated|nsubjpass|Radiosensitization Radiosensitization|nmod|cells cells|compound|END_ENTITY	Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat_shock_protein_70 -LRB- Hsp70 -RRB- levels .
24678590	0	Hsp70	86,91	p53	103,106	Hsp70	p53	3308	7157	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines .
8940078	0	Hsp70	102,107	p53	74,77	Hsp70	p53	15511(Tax:10090)	22060(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70 .
21683684	0	Hsp70	34,39	phospholipase_A2	14,30	Hsp70	phospholipase A2	3308	151056	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of phospholipase_A2 by Hsp70 in vitro .
8468369	0	Hsp70	22,27	transforming_growth_factor-beta_1	64,97	Hsp70	transforming growth factor-beta 1	423504(Tax:9031)	100873157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of chicken Hsp70 and Hsp90 family gene expression by transforming_growth_factor-beta_1 .
11466217	0	Hsp70-2	150,157	MSJ-1	0,5	Hsp70-2	MSJ-1	15512(Tax:10090)	15504(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	MSJ-1 , a mouse testis-specific DnaJ protein , is highly expressed in haploid male germ cells and interacts with the testis-specific heat_shock protein Hsp70-2 .
21730052	0	Hsp70-like_protein_1	45,65	Toll-like_receptor_4	0,20	Hsp70-like protein 1	Toll-like receptor 4	51182	7099	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Toll-like_receptor_4 -LRB- TLR4 -RRB- is essential for Hsp70-like_protein_1 -LRB- HSP70L1 -RRB- to activate dendritic cells and induce Th1 response .
25940345	0	Hsp72	0,5	Nek6	44,48	Hsp72	Nek6	3303	10783	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression .
11971973	0	Hsp72	0,5	c-jun_N-terminal_kinase	24,47	Hsp72	c-jun N-terminal kinase	3303	5599	Gene	Gene	regulate|nsubj|START_ENTITY regulate|advmod|END_ENTITY	Hsp72 and stress kinase c-jun_N-terminal_kinase regulate the bid-dependent pathway in tumor_necrosis_factor-induced apoptosis .
22289917	0	Hsp72	39,44	heat_shock_protein_72	16,37	Hsp72	heat shock protein 72	3303	3303	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Consequences of heat_shock_protein_72 -LRB- Hsp72 -RRB- expression and activity on stress-induced apoptosis in CD30 + NPM-ALK + anaplastic_large-cell_lymphomas .
14718530	0	Hsp72	0,5	paxillin	21,29	Hsp72	paxillin	3303	5829	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hsp72 interacts with paxillin and facilitates the reassembly of focal adhesions during recovery from ATP depletion .
16765060	0	Hsp78	26,31	ClpB	51,55	Hsp78	ClpB	81570	81570	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Structure and function of Hsp78 , the mitochondrial ClpB homolog .
22178220	0	Hsp90	0,5	AMPK	21,25	Hsp90	AMPK	3320	5563	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation .
25347845	0	Hsp90	33,38	ARF6	8,12	Hsp90	ARF6	3320	382	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of ARF6 , Rab11 and External Hsp90 in the Trafficking and Recycling of Recombinant-Soluble Neisseria_meningitidisAdhesin A -LRB- rNadA -RRB- in Human Epithelial Cells .
14739935	0	Hsp90	69,74	ATPase	40,46	Hsp90	ATPase	3320	1769	Gene	Gene	machinery|amod|START_ENTITY Aha1|nmod|machinery Aha1|nsubj|basis basis|nmod|recruitment recruitment|nmod|activator activator|compound|END_ENTITY	Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery .
15039704	0	Hsp90	69,74	ATPase	40,46	Hsp90	ATPase	3320	1769	Gene	Gene	machinery|amod|START_ENTITY Aha1|nmod|machinery Aha1|nsubj|basis basis|nmod|recruitment recruitment|nmod|activator activator|compound|END_ENTITY	Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery .
15937123	0	Hsp90	19,24	ATPase	56,62	Hsp90	ATPase	3320	1769	Gene	Gene	S-nitrosylation|nmod|START_ENTITY promotes|nsubj|S-nitrosylation promotes|dobj|inhibition inhibition|nmod|END_ENTITY	S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric_oxide synthase regulatory activities .
18400751	0	Hsp90	62,67	ATPase	40,46	Hsp90	ATPase	3320	1769	Gene	Gene	changes|nmod|START_ENTITY changes|nmod|cycle cycle|compound|END_ENTITY	Conserved conformational changes in the ATPase cycle of human Hsp90 .
19856130	0	Hsp90	61,66	ATPase	42,48	Hsp90	ATPase	3320	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype .
20089831	0	Hsp90	55,60	ATPase	61,67	Hsp90	ATPase	3320	1769	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic_fibrosis .
20226818	0	Hsp90	29,34	ATPase	35,41	Hsp90	ATPase	3320	1769	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo .
20376192	0	Hsp90	23,28	ATPase	49,55	Hsp90	ATPase	3320	1769	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity .
8419347	0	Hsp90	0,5	ATPase	26,32	Hsp90	ATPase	299331(Tax:10116)	1769	Gene	Gene	chaperonins|amod|START_ENTITY possess|nsubj|chaperonins possess|dobj|activity activity|compound|END_ENTITY	Hsp90 chaperonins possess ATPase activity and bind heat_shock transcription factors and peptidyl prolyl isomerases .
15584899	0	Hsp90	75,80	Aha1	0,4	Hsp90	Aha1	3320	10598	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Aha1 competes with Hop , p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone_receptor activation .
23166640	0	Hsp90	32,37	Aha1	78,82	Hsp90	Aha1	855836(Tax:4932)	851800(Tax:4932)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922 .
9843494	0	Hsp90	16,21	CFTR	47,51	Hsp90	CFTR	3320	1080	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome .
22843495	0	Hsp90	0,5	Cdc25A	17,23	Hsp90	Cdc25A	3320	993	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic_carcinoma cells .
14627196	0	Hsp90	18,23	Cdc37	0,5	Hsp90	Cdc37	855836(Tax:4932)	851746(Tax:4932)	Gene	Gene	goes|nmod|START_ENTITY goes|nsubj|END_ENTITY	Cdc37 goes beyond Hsp90 and kinases .
23569206	0	Hsp90	41,46	Cdc37	0,5	Hsp90	Cdc37	3320	11140	Gene	Gene	restricts|dobj|START_ENTITY restricts|nsubj|END_ENTITY	Cdc37 -LRB- cell_division_cycle_37 -RRB- restricts Hsp90 -LRB- heat_shock_protein_90 -RRB- motility by interaction with N-terminal and middle domain binding sites .
8666233	0	Hsp90	60,65	Cdk4	92,96	Hsp90	Cdk4	3320	1019	Gene	Gene	START_ENTITY|acl:relcl|binds binds|dobj|END_ENTITY	Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4 .
21819105	0	Hsp90	116,121	DJ-1	85,89	Hsp90	DJ-1	3320	11315	Gene	Gene	interactions|nmod|START_ENTITY END_ENTITY|nmod|interactions	Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90 .
10816560	0	Hsp90	70,75	GRP94	87,92	Hsp90	GRP94	3320	7184	Gene	Gene	chaperone|amod|START_ENTITY chaperone|appos|END_ENTITY	Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone , GRP94 .
10816561	0	Hsp90	70,75	GRP94	87,92	Hsp90	GRP94	3320	7184	Gene	Gene	chaperone|amod|START_ENTITY chaperone|appos|END_ENTITY	Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone , GRP94 .
15292259	0	Hsp90	74,79	GRP94	64,69	Hsp90	GRP94	3320	7184	Gene	Gene	chaperone|amod|START_ENTITY END_ENTITY|appos|chaperone	Ligand-induced conformational shift in the N-terminal domain of GRP94 , an Hsp90 chaperone .
16731965	0	Hsp90	62,67	GRP94	79,84	Hsp90	GRP94	3320	7184	Gene	Gene	chaperone|amod|START_ENTITY chaperone|appos|END_ENTITY	Identification of novel quaternary domain interactions in the Hsp90 chaperone , GRP94 .
9548957	0	Hsp90	99,104	GRP94	115,120	Hsp90	GRP94	3320	7184	Gene	Gene	activation|nmod|START_ENTITY accompanying|dobj|activation transitions|acl|accompanying chaperone|nsubj|transitions chaperone|dobj|END_ENTITY	Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94 .
10567567	0	Hsp90	0,5	Gcn2	26,30	Hsp90	Gcn2	855836(Tax:4932)	851877(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Hsp90 binds and regulates Gcn2 , the ligand-inducible kinase of the alpha subunit of eukaryotic translation initiation factor 2 -LSB- corrected -RSB- .
19554567	0	Hsp90	89,94	Grp94	0,5	Hsp90	Grp94	855836(Tax:4932)	22027(Tax:10090)	Gene	Gene	has|nmod|START_ENTITY has|nsubj|END_ENTITY	Grp94 , the endoplasmic reticulum Hsp90 , has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide .
26872972	0	Hsp90	54,59	Grp94	99,104	Hsp90	Grp94	3320	7184	Gene	Gene	Regulates|dep|START_ENTITY Regulates|nsubj|94 94|appos|END_ENTITY	Endoplasmic Reticulum Resident Heat_Shock_Protein_90 -LRB- Hsp90 -RRB- Isoform Glucose-Regulated Protein 94 -LRB- Grp94 -RRB- Regulates Cell Polarity and Cancer Cell Migration by Affecting Intracellular Transport .
15916966	0	Hsp90	16,21	HDAC6	0,5	Hsp90	HDAC6	3320	10013	Gene	Gene	acetylation|amod|START_ENTITY regulates|dobj|acetylation regulates|nsubj|END_ENTITY	HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid_receptor .
19158084	0	Hsp90	16,21	HDAC6	0,5	Hsp90	HDAC6	3320	10013	Gene	Gene	activity|amod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl_hydrocarbon_receptor signaling .
19855091	0	Hsp90	91,96	HDAC6	0,5	Hsp90	HDAC6	104434(Tax:10090)	15185(Tax:10090)	Gene	Gene	acetylation|amod|START_ENTITY modulating|dobj|acetylation hypersensitivity|acl|modulating regulates|dobj|hypersensitivity regulates|nsubj|END_ENTITY	HDAC6 regulates androgen_receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant_prostate_cancer .
21082217	0	Hsp90	120,125	HDAC6	86,91	Hsp90	HDAC6	3320	10013	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Carbamazepine promotes Her-2 protein degradation in breast_cancer cells by modulating HDAC6 activity and acetylation of Hsp90 .
17915561	0	Hsp90	18,23	HSF2	0,4	Hsp90	HSF2	3320	3298	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	HSF2 binds to the Hsp90 , Hsp27 , and c-Fos promoters constitutively and modulates their expression .
11751848	0	Hsp90	24,29	Hap1	94,98	Hsp90	Hap1	855836(Tax:4932)	850958(Tax:4932)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1 .
12897155	0	Hsp90	102,107	Hap1	156,160	Hsp90	Hap1	3320	9001	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1 .
15102838	0	Hsp90	85,90	Hap1	53,57	Hsp90	Hap1	855836(Tax:4932)	850958(Tax:4932)	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	A novel mode of chaperone action : heme activation of Hap1 by enhanced association of Hsp90 with the repressed Hsp70-Hap1 complex .
11504706	0	Hsp90	24,29	Hck	79,82	Hsp90	Hck	3320	3055	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart .
25141341	0	Hsp90	68,73	Heat_Shock_Protein_90	45,66	Hsp90	Heat Shock Protein 90	3320	3320	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Progress in the Discovery and Development of Heat_Shock_Protein_90 -LRB- Hsp90 -RRB- Inhibitors .
22431752	0	Hsp90	61,66	Hectd1	0,6	Hsp90	Hectd1	111058(Tax:10090)	207304(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Hectd1 regulates intracellular localization and secretion of Hsp90 to control cellular behavior of the cranial mesenchyme .
17080460	0	Hsp90	61,66	Hsp27	47,52	Hsp90	Hsp27	3320	3315	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of 50 Hz sinusoidal magnetic fields on Hsp27 , Hsp70 , Hsp90 expression in porcine aortic endothelial cells -LRB- PAEC -RRB- .
25583479	0	Hsp90	67,72	Hsp27	54,59	Hsp90	Hsp27	3320	3315	Gene	Gene	complex|amod|START_ENTITY recruits|nmod|complex recruits|dobj|END_ENTITY	Mutant glucocerebrosidase in Gaucher_disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation .
16854979	0	Hsp90	53,58	Hsp40	30,35	Hsp90	Hsp40	3320	3337	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Defining the requirements for Hsp40 and Hsp70 in the Hsp90 chaperone pathway .
11877417	1	Hsp90	101,106	Hsp70	87,92	Hsp90	Hsp70	3320	3308	Gene	Gene	complexes|amod|START_ENTITY Hop|dobj|complexes Hop|nsubj|Relevance Relevance|nmod|EEVD-recognition EEVD-recognition|nmod|END_ENTITY	Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes .
12459260	0	Hsp90	41,46	Hsp70	101,106	Hsp90	Hsp70	3320	3308	Gene	Gene	relationships|nmod|START_ENTITY homologs|nsubj|relationships homologs|xcomp|reveal reveal|nmod|END_ENTITY	Phylogenetic relationships of organellar Hsp90 homologs reveal fundamental differences to organellar Hsp70 and Hsp60 evolution .
17080460	0	Hsp90	61,66	Hsp70	54,59	Hsp90	Hsp70	3320	3308	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of 50 Hz sinusoidal magnetic fields on Hsp27 , Hsp70 , Hsp90 expression in porcine aortic endothelial cells -LRB- PAEC -RRB- .
17397803	0	Hsp90	15,20	Hsp70	78,83	Hsp90	Hsp70	3320	3308	Gene	Gene	function|amod|START_ENTITY function|nmod|cells cells|nmod|hyperacetylation hyperacetylation|nmod|END_ENTITY	FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70 .
19747088	0	Hsp90	87,92	Hsp70	49,54	Hsp90	Hsp70	3320	3308	Gene	Gene	inhibitors|amod|START_ENTITY biomarker|nmod|inhibitors biomarker|nsubj|investigation investigation|nmod|use use|nmod|END_ENTITY	An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors .
23583203	0	Hsp90	98,103	Hsp70	0,5	Hsp90	Hsp70	3320	3308	Gene	Gene	inhibitor|nmod|START_ENTITY induced|nmod|inhibitor death|acl|induced enhances|dobj|death enhances|nsubj|silencing silencing|amod|END_ENTITY	Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90 .
25679754	0	Hsp90	61,66	Hsp70	13,18	Hsp90	Hsp70	3320	3308	Gene	Gene	inhibitor|amod|START_ENTITY Combining|nmod|inhibitor Combining|dobj|inhibitor inhibitor|amod|END_ENTITY	Combining an Hsp70 inhibitor with either an N - or C-terminal Hsp90 inhibitor produces mechanistically distinct phenotypes .
26565746	0	Hsp90	114,119	Hsp70	80,85	Hsp90	Hsp70	3320	3308	Gene	Gene	Protein|appos|START_ENTITY Protein|appos|END_ENTITY	Specific Binding of Tetratricopeptide Repeat Proteins to Heat_Shock Protein 70 -LRB- Hsp70 -RRB- and Heat_Shock Protein 90 -LRB- Hsp90 -RRB- Is Regulated by Affinity and Phosphorylation .
25024377	0	Hsp90	54,59	IL-17	63,68	Hsp90	IL-17	3320	3605	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling .
20864537	0	Hsp90	0,5	INrf2	23,28	Hsp90	INrf2	3320	9817	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Hsp90 interaction with INrf2 -LRB- Keap1 -RRB- mediates stress-induced Nrf2 activation .
15199125	0	Hsp90	43,48	Lck	36,39	Hsp90	Lck	3320	3932	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Regulation of the Src family kinase Lck by Hsp90 and ubiquitination .
26804907	0	Hsp90	33,38	Mps1	0,4	Hsp90	Mps1	3320	219972	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	Mps1 Mediated Phosphorylation of Hsp90 Confers Renal_Cell_Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors .
26804907	0	Hsp90	99,104	Mps1	0,4	Hsp90	Mps1	3320	219972	Gene	Gene	Inhibitors|compound|START_ENTITY Confers|nmod|Inhibitors Confers|nsubj|Phosphorylation Phosphorylation|compound|END_ENTITY	Mps1 Mediated Phosphorylation of Hsp90 Confers Renal_Cell_Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors .
11237709	0	Hsp90	23,28	Pim-1	14,19	Hsp90	Pim-1	3320	5292	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Pim-1 by Hsp90 .
16407978	0	Hsp90	73,78	Ppt1	16,20	Hsp90	Ppt1	855836(Tax:4932)	853023(Tax:4932)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90 .
26645561	0	Hsp90	33,38	SH-1242	16,23	Hsp90	SH-1242	3320	3481743(Tax:279808)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Deguelin analog SH-1242 inhibits Hsp90 activity and exerts potent anticancer efficacy with limited neurotoxicity .
21908611	0	Hsp90	49,54	SQUINT	39,45	Hsp90	SQUINT	855836(Tax:4932)	816074(Tax:3702)	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Binding of the cyclophilin_40 ortholog SQUINT to Hsp90 protein is required for SQUINT function in Arabidopsis .
20014282	0	Hsp90	36,41	STAT3	59,64	Hsp90	STAT3	104434(Tax:10090)	20848(Tax:10090)	Gene	Gene	association|amod|START_ENTITY promotes|dobj|association promotes|nmod|END_ENTITY	Leukemia_inhibitory_factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells .
22271514	0	Hsp90	30,35	STAT3	0,5	Hsp90	STAT3	3320	6774	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	STAT3 interacts directly with Hsp90 .
23145121	0	Hsp90	58,63	STAT3	103,108	Hsp90	STAT3	3320	6774	Gene	Gene	induces|nmod|START_ENTITY induces|advcl|suppress suppress|dobj|activation activation|nmod|END_ENTITY	Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3 .
15340069	0	Hsp90	21,26	Sgt1	0,4	Hsp90	Sgt1	855224(Tax:4932)	854222(Tax:4932)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Sgt1 associates with Hsp90 : an initial step of assembly of the core kinetochore complex .
19131964	0	Hsp90	24,29	Sgt1	0,4	Hsp90	Sgt1	3320	10910	Gene	Gene	co-chaperone|nmod|START_ENTITY stabilizes|nsubj|co-chaperone stabilizes|advmod|END_ENTITY	Sgt1 , a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization .
12525481	0	Hsp90	43,48	Sti1	0,4	Hsp90	Sti1	855836(Tax:4932)	854192(Tax:4932)	Gene	Gene	ATPase|compound|START_ENTITY inhibitor|nmod|ATPase inhibitor|nsubj|END_ENTITY	Sti1 is a non-competitive inhibitor of the Hsp90 ATPase .
14742721	0	Hsp90	29,34	Sti1	0,4	Hsp90	Sti1	855836(Tax:4932)	854192(Tax:4932)	Gene	Gene	stabilize|dobj|START_ENTITY stabilize|nsubj|END_ENTITY	Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase .
16219779	0	Hsp90	95,100	Sti1	87,91	Hsp90	Sti1	855836(Tax:4932)	854192(Tax:4932)	Gene	Gene	signaling|amod|START_ENTITY repeat|nmod|signaling repeat|dobj|domains domains|nmod|END_ENTITY	Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces_cerevisiae .
17101799	0	Hsp90	61,66	Sti1	97,101	Hsp90	Sti1	855836(Tax:4932)	854192(Tax:4932)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Nucleotide-dependent interaction of Saccharomyces_cerevisiae Hsp90 with the cochaperone proteins Sti1 , Cpr6 , and Sba1 .
25851214	0	Hsp90	0,5	Sti1	48,52	Hsp90	Sti1	3320	10963	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|dynamics dynamics|nmod|END_ENTITY	Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules .
8972212	0	Hsp90	24,29	Sti1	42,46	Hsp90	Sti1	855836(Tax:4932)	854192(Tax:4932)	Gene	Gene	analysis|nmod|START_ENTITY cochaperone|nmod|analysis cochaperone|nsubj|END_ENTITY	In vivo analysis of the Hsp90 cochaperone Sti1 -LRB- p60 -RRB- .
18591668	0	Hsp90	44,49	TGFbeta	23,30	Hsp90	TGFbeta	3320	7040	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Critical regulation of TGFbeta signaling by Hsp90 .
11413145	0	Hsp90	53,58	Thrombin_receptor	0,17	Hsp90	Thrombin receptor	111058(Tax:10090)	14062(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Thrombin_receptor signaling to cytoskeleton requires Hsp90 .
24647762	0	Hsp90	54,59	Utp21	33,38	Hsp90	Utp21	855836(Tax:4932)	851125(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The ribosomal biogenesis protein Utp21 interacts with Hsp90 and has differing requirements for Hsp90-associated proteins .
17855507	0	Hsp90	32,37	VEGF	89,93	Hsp90	VEGF	3326	7422	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Src-mediated phosphorylation of Hsp90 in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- is required for VEGF receptor-2 signaling to endothelial_NO_synthase .
20519952	0	Hsp90	0,5	Wee1	23,27	Hsp90	Wee1	855836(Tax:4932)	853252(Tax:4932)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Hsp90 phosphorylation , Wee1 and the cell cycle .
19458189	0	Hsp90	0,5	argonaute_2	32,43	Hsp90	argonaute 2	3320	27161	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	Hsp90 regulates the function of argonaute_2 and its recruitment to stress granules and P-bodies .
17891170	0	Hsp90	21,26	c-Jun_N-terminal_kinase	51,74	Hsp90	c-Jun N-terminal kinase	3320	5599	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Proapoptotic role of Hsp90 by its interaction with c-Jun_N-terminal_kinase in lipid rafts in edelfosine-mediated antileukemic therapy .
10747020	0	Hsp90	0,5	c-Mos	22,27	Hsp90	c-Mos	444024(Tax:8355)	397924(Tax:8355)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes .
15062560	0	Hsp90	70,75	glucocorticoid_receptor	35,58	Hsp90	glucocorticoid receptor	3320	2908	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of nuclear retention of glucocorticoid_receptor by nuclear Hsp90 .
19751963	0	Hsp90	73,78	hTERT	101,106	Hsp90	hTERT	3320	7015	Gene	Gene	p23|amod|START_ENTITY dissociating|dobj|p23 dissociating|nmod|END_ENTITY	Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT .
26581400	0	Hsp90	56,61	heat_shock_protein_90	34,55	Hsp90	heat shock protein 90	3320	3320	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	A phase II trial of ganetespib , a heat_shock_protein_90 Hsp90 -RRB- inhibitor , in patients with docetaxel-pretreated metastatic castrate-resistant prostate_cancer -LRB- CRPC -RRB- - a prostate_cancer clinical trials consortium -LRB- PCCTC -RRB- study .
15777846	0	Hsp90	0,5	hsp70	39,44	Hsp90	hsp70	3320	3308	Gene	Gene	geldanamycin|amod|START_ENTITY increases|nsubj|geldanamycin increases|dobj|stabilisation stabilisation|amod|END_ENTITY	Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic_pressure .
22128174	0	Hsp90	105,110	nitric-oxide_synthase	55,76	Hsp90	nitric-oxide synthase	3320	4842	Gene	Gene	proteins|amod|START_ENTITY binding|nmod|proteins regulates|dobj|binding regulates|nsubj|Modulation Modulation|nmod|cleft cleft|nmod|END_ENTITY	Modulation of heme/substrate binding cleft of neuronal nitric-oxide_synthase -LRB- nNOS -RRB- regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination .
8666233	0	Hsp90	60,65	p50Cdc37	10,18	Hsp90	p50Cdc37	3320	11140	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4 .
12163643	0	Hsp90	85,90	p53	26,29	Hsp90	p53	3320	7157	Gene	Gene	bound|nmod|START_ENTITY domain|acl|bound domain|compound|END_ENTITY	CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90 .
15358769	0	Hsp90	0,5	p53	27,30	Hsp90	p53	3320	7157	Gene	Gene	chaperones|nsubj|START_ENTITY chaperones|dobj|protein protein|compound|END_ENTITY	Hsp90 chaperones wild-type p53 tumor suppressor protein .
15358771	0	Hsp90	0,5	p53	42,45	Hsp90	p53	3320	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures .
15613472	0	Hsp90	0,5	p53	150,153	Hsp90	p53	3320	7157	Gene	Gene	essential|nsubj|START_ENTITY essential|advcl|restoring restoring|dobj|functions functions|dep|stabilization stabilization|nmod|END_ENTITY	Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53 : implications for cancer therapy .
15613472	0	Hsp90	0,5	p53	77,80	Hsp90	p53	3320	7157	Gene	Gene	essential|nsubj|START_ENTITY essential|advcl|restoring restoring|dobj|functions functions|nmod|protein protein|compound|END_ENTITY	Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53 : implications for cancer therapy .
17982489	0	Hsp90	0,5	p53	62,65	Hsp90	p53	3320	7157	Gene	Gene	inhibition|amod|START_ENTITY has|nsubj|inhibition has|dobj|effects effects|nmod|END_ENTITY	Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic_lymphocytic_leukaemia cells .
19956882	0	Hsp90	74,79	p53	0,3	Hsp90	p53	3320	7157	Gene	Gene	lines|nmod|START_ENTITY radio-sensitization|nmod|lines radio-sensitization|compound|END_ENTITY	p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin .
20688913	0	Hsp90	15,20	p53	64,67	Hsp90	p53	3320	7157	Gene	Gene	binding|nmod|START_ENTITY sufficient|nsubj|binding sufficient|nmod|chaperoning chaperoning|nmod|protein protein|compound|END_ENTITY	ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein .
21109931	0	Hsp90	0,5	p53	27,30	Hsp90	p53	3320	7157	Gene	Gene	inhibition|amod|START_ENTITY increases|nsubj|inhibition increases|dobj|expression expression|compound|END_ENTITY	Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma .
21460846	0	Hsp90	77,82	p53	19,22	Hsp90	p53	3320	7157	Gene	Gene	presence|nmod|START_ENTITY state|nmod|presence adopts|dobj|state adopts|nsubj|END_ENTITY	The client protein p53 adopts a molten globule-like state in the presence of Hsp90 .
21658391	0	Hsp90	23,28	p53	53,56	Hsp90	p53	3320	7157	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Dynamic Interaction of Hsp90 with Its Client Protein p53 .
24451373	0	Hsp90	22,27	p53	0,3	Hsp90	p53	3320	7157	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|protein protein|compound|END_ENTITY	p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression .
24736433	0	Hsp90	14,19	p53	0,3	Hsp90	p53	3320	7157	Gene	Gene	activity|amod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	p53 modulates Hsp90 ATPase activity and regulates aryl_hydrocarbon_receptor signaling .
26277488	0	Hsp90	73,78	p53	52,55	Hsp90	p53	3320	7157	Gene	Gene	Prediction|nmod|START_ENTITY Prediction|nmod|activator activator|nmod|END_ENTITY	Prediction of dual agents as an activator of mutant p53 and inhibitor of Hsp90 by docking , molecular dynamic simulation and virtual screening .
24564321	0	Hsp90	0,5	part_1	18,24	Hsp90	part 1	3320	25859	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Hsp90 inhibitors , part_1 : definition of 3-D QSAutogrid/R models as a tool for virtual screening .
12905636	0	Hsp90_beta	61,71	p53	54,57	Hsp90 beta	p53	3326	7157	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The role of p53 binding site on the trans binding of p53 to Hsp90_beta gene -RSB- .
22552610	0	Hsp90a	20,26	STAT5b	42,48	Hsp90a	STAT5b	3324	6777	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Hypoxia upregulates Hsp90a expression via STAT5b in cancer cells .
21063103	0	Hsp90a	19,25	eNOS	40,44	Hsp90a	eNOS	3324	4846	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Opposite effect of Hsp90a and Hsp90b on eNOS ability to produce nitric_oxide or superoxide anion in human embryonic kidney cells .
23836447	0	Hsp90a	99,105	endothelial_nitric_oxide_synthase	23,56	Hsp90a	endothelial nitric oxide synthase	3324	4846	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Humic_acid induces the endothelial_nitric_oxide_synthase phosphorylation at Ser1177 and Thr495_Via Hsp90a and Hsp90b upregulation in human umbilical vein endothelial cells .
8641459	0	Hsp90alpha	49,59	Interleukin-4	0,13	Hsp90alpha	Interleukin-4	3320	3565	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Interleukin-4 upregulates the heat_shock protein Hsp90alpha and enhances transcription of a reporter gene coupled to a single heat_shock element .
18996350	0	Hsp90beta	14,23	p53	0,3	Hsp90beta	p53	3326	7157	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p53 regulates Hsp90beta during arsenite-induced cytotoxicity in glutathione-deficient cells .
22528050	0	HspA1A	19,25	TLR2	31,35	HspA1A	TLR2	3303	7097	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian_cancer cells in vitro .
24898650	0	HspB1	56,61	amyloid-b_protein_precursor	14,41	HspB1	amyloid-b protein precursor	3315	351	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of amyloid-b_protein_precursor expression by HspB1 .
23055712	0	HspB5	53,58	heat-shock_protein_aB-crystalline	18,51	HspB5	heat-shock protein aB-crystalline	1410	1410	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of small heat-shock_protein_aB-crystalline -LRB- HspB5 -RRB- in COPD pathogenesis .
21767525	0	HspB8	57,62	Bag3	71,75	HspB8	Bag3	26353	9531	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Biochemical characterization of small heat_shock protein HspB8 -LRB- Hsp22 -RRB- - Bag3 interaction .
21526341	0	HspB8	50,55	Hsp22	57,62	HspB8	Hsp22	26353	26353	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of human small heat shock protein HspB8 -LRB- Hsp22 -RRB- by ERK1 protein kinase .
21767525	0	HspB8	57,62	Hsp22	64,69	HspB8	Hsp22	26353	26353	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biochemical characterization of small heat_shock protein HspB8 -LRB- Hsp22 -RRB- - Bag3 interaction .
12417338	0	HspBP1	0,6	Fes1	33,37	HspBP1	Fes1	23640	852397(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	HspBP1 , a homologue of the yeast Fes1 and Sls1 proteins , is an Hsc70 nucleotide exchange factor .
12417338	0	HspBP1	0,6	Hsc70	63,68	HspBP1	Hsc70	23640	3312	Gene	Gene	factor|nsubj|START_ENTITY factor|amod|END_ENTITY	HspBP1 , a homologue of the yeast Fes1 and Sls1 proteins , is an Hsc70 nucleotide exchange factor .
16827227	0	HspBP1	64,70	HspBP1	95,101	HspBP1	HspBP1	23640	23640	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Human serum contains detectable levels of the Hsp70 cochaperone HspBP1 and antibodies bound to HspBP1 .
16827227	0	HspBP1	95,101	HspBP1	64,70	HspBP1	HspBP1	23640	23640	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Human serum contains detectable levels of the Hsp70 cochaperone HspBP1 and antibodies bound to HspBP1 .
18986301	0	HspBP1	14,20	epidermal_growth_factor_receptor	56,88	HspBP1	epidermal growth factor receptor	23640	1956	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Extracellular HspBP1 and Hsp72 synergistically activate epidermal_growth_factor_receptor .
9727040	0	Hsp_27	52,58	p38_mitogen-activated_protein_kinase	15,51	Hsp 27	p38 mitogen-activated protein kinase	24471(Tax:10116)	81649(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	A role for the p38_mitogen-activated_protein_kinase / Hsp_27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini .
16142794	0	Hsp_70	45,51	heat_shock_protein_70	22,43	Hsp 70	heat shock protein 70	3308	3308	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of heat_shock_protein_70 -LRB- Hsp_70 -RRB- in boar spermatozoa and its role during fertilization .
22869728	0	Hspa13	22,28	Stch	30,34	Hspa13	Stch	110920(Tax:10090)	110920(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Overexpression of the Hspa13 -LRB- Stch -RRB- gene reduces prion_disease incubation time in mice .
23133405	0	Hst1	60,64	Prdm9	53,58	Hst1	Prdm9	109727(Tax:10090)	213389(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interallelic and intergenic incompatibilities of the Prdm9 -LRB- Hst1 -RRB- gene in mouse hybrid sterility .
17110954	0	Hst2	56,60	Sir2	41,45	Hst2	Sir2	2251	22933	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Nuclear export modulates the cytoplasmic Sir2 homologue Hst2 .
1765383	0	Htr-2	34,39	Es-10	61,66	Htr-2	Es-10	15558(Tax:10090)	13885(Tax:10090)	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	The 5-HT2 serotonin receptor gene Htr-2 is tightly linked to Es-10 on mouse chromosome 14 .
20943460	0	HtrA1	16,21	Serine_protease	0,15	HtrA1	Serine protease	5654	2147	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Serine_protease HtrA1 expression in human hepatocellular_carcinoma .
25726184	0	HtrA1	0,5	TGF-b1	89,95	HtrA1	TGF-b1	5654	7040	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	HtrA1 may regulate the osteogenic differentiation of human periodontal ligament cells by TGF-b1 .
17906618	0	HtrA2	27,32	PINK1	87,92	HtrA2	PINK1	27429	65018	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The mitochondrial protease HtrA2 is regulated by Parkinson 's _ disease-associated kinase PINK1 .
25086674	0	HtrA2	76,81	high_temperature_required_A2	46,74	HtrA2	high temperature required A2	27429	27429	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	The expression levels and prognostic value of high_temperature_required_A2 -LRB- HtrA2 -RRB- in NSCLC .
18786092	0	HtrA2	14,19	serine_protease	37,52	HtrA2	serine protease	27429	2147	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation of HtrA2 , a mitochondrial serine_protease mediates apoptosis : current knowledge on HtrA2 mediated myocardial_ischemia / reperfusion injury .
19951697	0	HtrA3	0,5	PPARgamma	76,85	HtrA3	PPARgamma	94031	5468	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	HtrA3 is regulated by 15-deoxy-Delta12 ,14 - prostaglandin_J2 independently of PPARgamma in clear_cell_renal_cell_carcinomas .
18606591	0	Htra2	21,26	serine-protease	27,42	Htra2	serine-protease	27429	2147	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon_cancer cells .
23319588	0	Htt	89,92	Huntingtin	77,87	Htt	Huntingtin	3064	3064	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin -LRB- Htt -RRB- protein exon 1 .
24729624	0	HuR	20,23	ABCA1	52,57	HuR	ABCA1	1994	19	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	RNA_binding_protein HuR regulates the expression of ABCA1 .
11971974	0	HuR	43,46	AMP-activated_kinase	0,20	HuR	AMP-activated kinase	1994	5563	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	AMP-activated_kinase regulates cytoplasmic HuR .
22362742	0	HuR	38,41	AT1R	14,18	HuR	AT1R	1994	185	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of AT1R expression through HuR by insulin .
20498276	0	HuR	0,3	AUF1	9,13	HuR	AUF1	1994	3184	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	HuR uses AUF1 as a cofactor to promote p16INK4 mRNA decay .
19671677	0	HuR	34,37	Bcl-2	14,19	HuR	Bcl-2	1994	596	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells .
26438598	0	HuR	105,108	C-reactive_protein	59,77	HuR	C-reactive protein	1994	1401	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Post-transcriptional regulation of the inflammatory marker C-reactive_protein by the RNA-binding protein HuR and miR-637 .
24477678	0	HuR	48,51	CD4	55,58	HuR	CD4	15568(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Conditional knockout of the RNA-binding protein HuR in CD4 T cells reveals a gene dosage effect on cytokine production .
16484227	0	HuR	35,38	CD83	14,18	HuR	CD83	1994	9308	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element .
17383427	0	HuR	51,54	COX-2	89,94	HuR	COX-2	1994	5743	Gene	Gene	antagonism|nmod|START_ENTITY determines|nsubj|antagonism determines|dobj|fate fate|nmod|translation translation|compound|END_ENTITY	Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation .
18468781	0	HuR	36,39	COX-2	69,74	HuR	COX-2	1994	4513	Gene	Gene	Overexpression|nmod|START_ENTITY associated|nsubjpass|Overexpression associated|nmod|expression expression|compound|END_ENTITY	Overexpression of ELAV-like protein HuR is associated with increased COX-2 expression in atrophy , high-grade_prostatic_intraepithelial_neoplasia , and incidental_prostate_cancer in cystoprostatectomies .
18705402	0	HuR	67,70	COX-2	93,98	HuR	COX-2	1994	5743	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of embryonic_lethal_abnormal_vision -LRB- ELAV -RRB- - like protein HuR and cyclooxygenase-2 -LRB- COX-2 -RRB- in Ewing_sarcoma .
19917608	0	HuR	8,11	COX-2	84,89	HuR	COX-2	1994	5743	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT .
22049153	0	HuR	26,29	COX-2	64,69	HuR	COX-2	1994	4513	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|microRNA-16 microRNA-16|nmod|END_ENTITY	The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2 .
25653183	0	HuR	0,3	COX-2	77,82	HuR	COX-2	15568(Tax:10090)	17709(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|expression expression|compound|END_ENTITY	HuR mediates the synergistic effects of angiotensin_II and IL-1b on vascular COX-2 expression and cell migration .
26498465	0	HuR	46,49	COX-2	73,78	HuR	COX-2	1994	5743	Gene	Gene	Receptor|appos|START_ENTITY Receptor|appos|END_ENTITY	Clinical Significance of Hu-Antigen Receptor -LRB- HuR -RRB- and Cyclooxygenase-2 -LRB- COX-2 -RRB- Expression in Human Malignant and Benign Thyroid Lesions .
23772036	0	HuR	0,3	CXCL1	48,53	HuR	CXCL1	1994	2919	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization .
25830480	0	HuR	22,25	Cyclin_E1	40,49	HuR	Cyclin E1	1994	898	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	MicroRNA-16 Modulates HuR Regulation of Cyclin_E1 in Breast_Cancer Cells .
13679363	0	HuR	89,92	ElrA	60,64	HuR	ElrA	495680(Tax:8355)	495680(Tax:8355)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Xenopus_cold-inducible_RNA-binding_protein_2 interacts with ElrA , the Xenopus homolog of HuR , and inhibits deadenylation of specific mRNAs .
20007147	0	HuR	26,29	HuR	38,41	HuR	HuR	1994	1994	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence .
20007147	0	HuR	38,41	HuR	26,29	HuR	HuR	1994	1994	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence .
18279945	0	HuR	84,87	IL-13	34,39	HuR	IL-13	1994	3596	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Posttranscriptional regulation of IL-13 in T cells : role of the RNA-binding protein HuR .
22426177	0	HuR	0,3	IL-6	51,55	HuR	IL-6	1994	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	HuR post-transcriptionally regulates TNF-a-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin .
25143867	0	HuR	26,29	MicroRNA-570-3p	0,15	HuR	MicroRNA-570-3p	1994	100847081	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-570-3p regulates HuR and cytokine expression in airway epithelial cells .
23605320	0	HuR	12,15	P-gp	43,47	HuR	P-gp	1994	5243	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Cytoplasmic HuR expression correlates with P-gp , HER-2 positivity , and poor outcome in breast_cancer .
20064878	0	HuR	66,69	RNPC1	0,5	HuR	RNPC1	1994	55544	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	RNPC1 modulates the RNA-binding activity of , and cooperates with , HuR to regulate p21 mRNA stability .
23176121	0	HuR	57,60	Sp1	29,32	HuR	Sp1	1994	6667	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of transcription factor Sp1 and RNA binding protein HuR in the downregulation of Dr + Escherichia_coli receptor protein decay accelerating factor -LRB- DAF or CD55 -RRB- by nitric_oxide .
11160917	0	HuR	123,126	TNFalpha	130,138	HuR	TNFalpha	15568(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Polymorphism in the 3 ' - untranslated region of TNFalpha mRNA impairs binding of the post-transcriptional regulatory protein HuR to TNFalpha mRNA .
12876290	0	HuR	50,53	TNFalpha	61,69	HuR	TNFalpha	363854(Tax:10116)	24835(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Chronic ethanol exposure increases the binding of HuR to the TNFalpha 3 ' - untranslated region in macrophages .
21646354	0	HuR	66,69	Transportin_2	0,13	HuR	Transportin 2	1994	30000	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Transportin_2 regulates apoptosis through the RNA-binding protein HuR .
24536047	0	HuR	0,3	WEE1	36,40	HuR	WEE1	1994	7465	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	HuR posttranscriptionally regulates WEE1 : implications for the DNA damage response in pancreatic_cancer cells .
19825980	0	HuR	59,62	XIAP	17,21	HuR	XIAP	1994	331	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines .
15878846	0	HuR	24,27	acetylcholinesterase	37,57	HuR	acetylcholinesterase	15568(Tax:10090)	11423(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	The RNA-binding protein HuR binds to acetylcholinesterase transcripts and regulates their expression in differentiating skeletal muscle cells .
25653183	0	HuR	0,3	angiotensin_II	40,54	HuR	angiotensin II	15568(Tax:10090)	11606(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	HuR mediates the synergistic effects of angiotensin_II and IL-1b on vascular COX-2 expression and cell migration .
19520857	0	HuR	115,118	bcl-2	60,65	HuR	bcl-2	1994	596	Gene	Gene	activity|compound|START_ENTITY overcoming|dobj|activity turnover|acl|overcoming turnover|amod|END_ENTITY	B_cell_lymphoma _ -LRB- Bcl -RRB- -2 protein is the major determinant in bcl-2 adenine-uridine-rich element turnover overcoming HuR activity .
23259573	0	HuR	0,3	cyclin_A	56,64	HuR	cyclin A	1994	890	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|compound|END_ENTITY	HuR cytoplasmic expression is associated with increased cyclin_A expression and poor outcome with upper_urinary_tract_urothelial_carcinoma .
23889148	0	HuR	0,3	cyclin_A	56,64	HuR	cyclin A	1994	890	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|compound|END_ENTITY	HuR cytoplasmic expression is associated with increased cyclin_A expression and inferior disease-free survival in patients with gastrointestinal_stromal_tumours -LRB- GISTs -RRB- .
16912169	0	HuR	0,3	cyclin_E1	19,28	HuR	cyclin E1	1994	898	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|deregulation deregulation|amod|END_ENTITY	HuR contributes to cyclin_E1 deregulation in MCF-7 breast_cancer cells .
11733561	0	HuR	48,51	cyclooxygenase-2	61,77	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	expression|nmod|START_ENTITY promotes|nsubj|expression promotes|dobj|expression expression|amod|END_ENTITY	Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon_cancer cells .
12704185	0	HuR	24,27	cyclooxygenase-2	56,72	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The RNA-binding protein HuR regulates the expression of cyclooxygenase-2 .
12855701	0	HuR	127,130	cyclooxygenase-2	53,69	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	TIAR|compound|START_ENTITY containing|dobj|TIAR complex|acl|containing recognized|nmod|complex recognized|nsubjpass|region region|nmod|END_ENTITY	The proximal region of the 3 ' - untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR , TIA-1 , TIAR , and the heterogeneous_nuclear_ribonucleoprotein_U .
17208222	0	HuR	127,130	cyclooxygenase-2	25,41	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	shuttling|nmod|START_ENTITY inhibiting|dobj|shuttling destabilizes|advcl|inhibiting destabilizes|dobj|mRNA mRNA|amod|END_ENTITY	Thalidomide destabilizes cyclooxygenase-2 mRNA by inhibiting p38_mitogen-activated_protein_kinase and cytoplasmic shuttling of HuR .
17392515	0	HuR	80,83	cyclooxygenase-2	136,152	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|dep|implications implications|nmod|regulation regulation|nmod|END_ENTITY	Protein_kinase_C_alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR : implications for posttranscriptional regulation of cyclooxygenase-2 .
17448140	0	HuR	63,66	cyclooxygenase-2	18,34	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	expression|compound|START_ENTITY Overexpression|nmod|expression Overexpression|nmod|correlates correlates|amod|END_ENTITY	Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary_mucoepidermoid_carcinoma but not in pleomorphic_adenoma .
17581403	0	HuR	14,17	cyclooxygenase-2	47,63	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|expression expression|amod|END_ENTITY	Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical_carcinoma .
18027256	0	HuR	12,15	cyclooxygenase-2	61,77	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	over-expression|compound|START_ENTITY associated|nsubjpass|over-expression associated|nmod|expression expression|amod|END_ENTITY	Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal_squamous_cell_carcinomas .
18831511	0	HuR	64,67	cyclooxygenase-2	108,124	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|association association|nmod|END_ENTITY	Expression of the embryonic_lethal_abnormal_vision-like protein HuR in human mesothelioma : association with cyclooxygenase-2 and prognosis .
19707506	0	HuR	26,29	cyclooxygenase-2	44,60	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	expression|nmod|START_ENTITY related|nsubjpass|expression related|nmod|expression expression|amod|END_ENTITY	Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon_cancer .
21391979	0	HuR	132,135	cyclooxygenase-2	14,30	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 and cytosolic phospholipase A2 gene expression by lipopolysaccharide through the RNA-binding protein HuR : involvement of NADPH oxidase , reactive oxygen species and mitogen-activated protein kinases .
21572400	0	HuR	14,17	cyclooxygenase-2	83,99	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	Expression|nmod|START_ENTITY stabilizes|nsubj|Expression stabilizes|xcomp|END_ENTITY	Expression of HuR , COX-2 , and survivin in lung_cancers ; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous_cell_carcinomas .
21572400	0	HuR	68,71	cyclooxygenase-2	83,99	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	HuR|dep|START_ENTITY Expression|nmod|HuR stabilizes|nsubj|Expression stabilizes|xcomp|END_ENTITY	Expression of HuR , COX-2 , and survivin in lung_cancers ; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous_cell_carcinomas .
23355539	0	HuR	84,87	cyclooxygenase-2	19,35	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	interaction|compound|START_ENTITY enhances|nsubj|interaction expression|parataxis|enhances expression|amod|END_ENTITY	Lapatinib-mediated cyclooxygenase-2 expression via epidermal_growth_factor_receptor / HuR interaction enhances the aggressiveness of triple-negative breast_cancer cells .
24086407	0	HuR	57,60	cyclooxygenase-2	96,112	HuR	cyclooxygenase-2	1994	5743	Gene	Gene	retention|nmod|START_ENTITY suppresses|nsubj|retention suppresses|dobj|independent independent|amod|END_ENTITY	Aryl_hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding .
19208339	0	HuR	26,29	cyclooxygenase_2	59,75	HuR	cyclooxygenase 2	1994	5743	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase_2 expression during colon_carcinogenesis .
16639702	0	HuR	84,87	glucose_transporter	18,37	HuR	glucose transporter	15568(Tax:10090)	20525(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|regulation regulation|nmod|END_ENTITY	The regulation of glucose_transporter -LRB- GLUT1 -RRB- expression by the RNA binding protein HuR .
19931428	0	HuR	25,28	hnRNP	34,39	HuR	hnRNP	1994	3183	Gene	Gene	association|nmod|START_ENTITY association|nmod|proteins proteins|compound|END_ENTITY	Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes .
19931428	0	HuR	25,28	hnRNP	71,76	HuR	hnRNP	1994	3183	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes .
23804758	0	HuR	22,25	miR-195	0,7	HuR	miR-195	1994	406971	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	miR-195 competes with HuR to modulate stim1 mRNA stability and regulate cell migration .
26731986	0	HuR	81,84	miR-31	0,6	HuR	miR-31	1994	407035	Gene	Gene	Growth|nmod|START_ENTITY Growth|amod|END_ENTITY	miR-31 Reduces Cell Growth of Papillary_Thyroid_Carcinoma by RNA-Binding Protein HuR .
14517280	0	HuR	37,40	p53	59,62	HuR	p53	1994	7157	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal_carcinoma cells .
18579691	0	HuR	20,23	thrombomodulin	39,53	HuR	thrombomodulin	1994	7056	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	RNA-binding protein HuR interacts with thrombomodulin 5 ` untranslated region and represses internal ribosome entry site-mediated translation under IL-1_beta treatment .
11834731	0	HuR	94,97	vascular_endothelial_growth_factor	51,85	HuR	vascular endothelial growth factor	1994	7422	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	A 40-bp RNA element that mediates stabilization of vascular_endothelial_growth_factor mRNA by HuR .
16306087	0	HuR	83,86	vascular_endothelial_growth_factor	117,151	HuR	vascular endothelial growth factor	1994	7422	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Antagonistic functions of tetradecanoyl_phorbol_acetate-inducible-sequence 11b and HuR in the hormonal regulation of vascular_endothelial_growth_factor messenger ribonucleic acid stability by adrenocorticotropin .
9497373	0	HuR	92,95	vascular_endothelial_growth_factor	25,59	HuR	vascular endothelial growth factor	1994	7422	Gene	Gene	stabilization|nmod|START_ENTITY stabilization|nmod|mRNA mRNA|compound|END_ENTITY	Hypoxic stabilization of vascular_endothelial_growth_factor mRNA by the RNA-binding protein HuR .
25239623	0	Hu_Antigen_R	0,12	TDP-43	67,73	Hu Antigen R	TDP-43	1994	23435	Gene	Gene	Regulator|nsubj|START_ENTITY Regulator|nmod|END_ENTITY	Hu_Antigen_R -LRB- HuR -RRB- is a Positive Regulator of RNA Binding Proteins TDP-43 and FUS/TLS : Implications for Amyotrophic Lateral_Sclerosis .
19805546	0	Hu_antigen_R	60,72	SOD1	44,48	Hu antigen R	SOD1	15568(Tax:10090)	20655(Tax:10090)	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	Amyotrophic_lateral_sclerosis-linked mutant SOD1 sequesters Hu_antigen_R -LRB- HuR -RRB- and TIA-1-related_protein -LRB- TIAR -RRB- : implications for impaired post-transcriptional regulation of vascular_endothelial_growth_factor .
25129460	0	Huh-7	128,133	GPC3	64,68	Huh-7	GPC3	284424	2719	Gene	Gene	START_ENTITY|nsubj|gene gene|compound|END_ENTITY	Lentivirus vectors construction of SiRNA targeting interference GPC3 gene and its biological effects on liver_cancer cell lines Huh-7 .
18996642	0	Huh-7	110,115	RhoA	102,106	Huh-7	RhoA	284424	387	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	A novel amplification target , ARHGAP5 , promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular_carcinoma cells .
18502465	0	Huh7	73,77	E3L	40,43	Huh7	E3L	284424	3707592(Tax:10245)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Antagonizing activity of vaccinia_virus E3L against human interferons in Huh7 cells .
22900205	0	Human_Epidermal_Growth_Factor_Receptor_2	29,69	HER2	71,75	Human Epidermal Growth Factor Receptor 2	HER2	2064	2064	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Relative Prognostic Value of Human_Epidermal_Growth_Factor_Receptor_2 -LRB- HER2 -RRB- Expression in Operable Oesophagogastric_Cancer .
26820945	0	Human_Epidermal_Growth_Factor_Receptor_2	14,54	HER2	56,60	Human Epidermal Growth Factor Receptor 2	HER2	2064	2064	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Evaluation of Human_Epidermal_Growth_Factor_Receptor_2 -LRB- HER2 -RRB- Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded -LRB- FFPE -RRB- Tissue Specimens by Fluorescence In Situ Hybridization -LRB- FISH -RRB- .
19582149	0	Human_I-mfa_domain_containing_protein	31,68	HIC	26,29	Human I-mfa domain containing protein	HIC	29969	29969	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The complex regulation of HIC -LRB- Human_I-mfa_domain_containing_protein -RRB- expression .
22092409	0	Human_epidermal_growth_factor_receptor_2	0,40	HER2	42,46	Human epidermal growth factor receptor 2	HER2	2064	2064	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Human_epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- immunoreactivity : specificity of three pharmacodiagnostic antibodies .
20445010	0	Human_leukocyte_antigen-G	0,25	HLA-G	27,32	Human leukocyte antigen-G	HLA-G	3135	3135	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human_leukocyte_antigen-G -LRB- HLA-G -RRB- expression in cervical_lesions : association with cancer_progression , _ HPV_16 / 18_infection , and host immune response .
10396290	0	Humara	88,94	androgen_receptor	64,81	Humara	androgen receptor	367	367	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Clonality analysis using X-chromosome inactivation at the human androgen_receptor gene -LRB- Humara -RRB- .
16522639	0	Huntingtin	51,61	Beclin_1	65,73	Huntingtin	Beclin 1	3064	8678	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of intracellular accumulation of mutant Huntingtin by Beclin_1 .
11137014	0	Huntingtin	36,46	FIP-2	0,5	Huntingtin	FIP-2	3064	10133	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	FIP-2 , a coiled-coil protein , links Huntingtin to Rab8 and modulates cellular morphogenesis .
8612237	0	Huntingtin	0,10	GAPDH	67,72	Huntingtin	GAPDH	3064	2597	Gene	Gene	proteins|compound|START_ENTITY interact|nsubj|proteins interact|nmod|END_ENTITY	Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH .
24651384	0	Huntingtin	35,45	HIP14	86,91	Huntingtin	HIP14	3064	23390	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L .
17947297	0	Huntingtin	8,18	HYPK	0,4	Huntingtin	HYPK	15194(Tax:10090)	67693(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	HYPK , a Huntingtin interacting protein , reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity .
25446099	0	Huntingtin	72,82	HYPK	18,22	Huntingtin	HYPK	3064	25764	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Chaperone protein HYPK interacts with the first 17 amino_acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity .
23319588	0	Huntingtin	77,87	Htt	89,92	Huntingtin	Htt	3064	3064	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin -LRB- Htt -RRB- protein exon 1 .
9809064	0	Huntingtin	27,37	SH3GL3	0,6	Huntingtin	SH3GL3	3064	6457	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates .
11043541	0	Huntingtin	57,67	Sp1	80,83	Huntingtin	Sp1	3064	6667	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|sites sites|amod|END_ENTITY	12-O-tetradecanoyl-phorbol-13-acetate down-regulates the Huntingtin promoter at Sp1 sites .
15689617	0	Huntingtin	114,124	cAMP-response_element-binding_protein	0,37	Huntingtin	cAMP-response element-binding protein	29424(Tax:10116)	81646(Tax:10116)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	cAMP-response_element-binding_protein contributes to suppression of the A2A_adenosine_receptor promoter by mutant Huntingtin with expanded polyglutamine residues .
9466992	0	Huntingtin	0,10	cystathionine_beta-synthase	26,53	Huntingtin	cystathionine beta-synthase	29424(Tax:10116)	24250(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Huntingtin interacts with cystathionine_beta-synthase .
9751154	0	Huntingtin-associated_protein	18,47	HAP1	49,53	Huntingtin-associated protein	HAP1	29430(Tax:10116)	29430(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The expression of Huntingtin-associated_protein -LRB- HAP1 -RRB- mRNA in developing , adult and ageing rat CNS : implications for Huntington 's _ disease neuropathology .
18636121	0	Huntingtin-associated_protein_1	0,31	Ahi1	47,51	Huntingtin-associated protein 1	Ahi1	15114(Tax:10090)	52906(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Huntingtin-associated_protein_1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice .
16782802	0	Huntingtin-associated_protein_1	0,31	androgen_receptor	54,71	Huntingtin-associated protein 1	androgen receptor	9001	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Huntingtin-associated_protein_1 -LRB- HAP1 -RRB- interacts with androgen_receptor -LRB- AR -RRB- and suppresses SBMA-mutant-AR-induced apoptosis .
25671650	0	Huntingtin-associated_protein_1	0,31	breakpoint_cluster_region_protein	47,80	Huntingtin-associated protein 1	breakpoint cluster region protein	15114(Tax:10090)	110279(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Huntingtin-associated_protein_1 interacts with breakpoint_cluster_region_protein to regulate neuronal differentiation .
12021262	0	Huntingtin-associated_protein_1	0,31	hepatocyte_growth_factor-regulated_tyrosine_kinase_substrate	47,107	Huntingtin-associated protein 1	hepatocyte growth factor-regulated tyrosine kinase substrate	9001	9146	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Huntingtin-associated_protein_1 interacts with hepatocyte_growth_factor-regulated_tyrosine_kinase_substrate and functions in endosomal trafficking .
12809493	0	Hurpin	0,6	cathepsin_L	45,56	Hurpin	cathepsin L	5275	1514	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Hurpin is a selective inhibitor of lysosomal cathepsin_L and protects keratinocytes from ultraviolet-induced apoptosis .
26698301	0	Huwe1	0,5	Gadd45b	21,28	Huwe1	Gadd45b	501546(Tax:10116)	299626(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells .
11164894	0	HveA	82,86	LT-alpha	37,45	HveA	LT-alpha	8764	4049	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	The three HveA receptor ligands , gD , LT-alpha and LIGHT bind to distinct sites on HveA .
16036799	0	HveC	9,13	Nectin-1	0,8	HveC	Nectin-1	5818	5818	Gene	Gene	Mediates|nsubj|START_ENTITY END_ENTITY|parataxis|Mediates	Nectin-1 / HveC Mediates herpes_simplex_virus_type_1 entry into primary human sensory neurons and fibroblasts .
11960552	0	Hyal-2	111,117	Transforming_growth_factor-beta1	0,32	Hyal-2	Transforming growth factor-beta1	15587(Tax:10090)	21803(Tax:10090)	Gene	Gene	blocks|nmod|START_ENTITY blocks|nsubj|END_ENTITY	Transforming_growth_factor-beta1 blocks the enhancement of tumor_necrosis_factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts .
25686832	0	Hyal-2	22,28	Zfra	0,4	Hyal-2	Zfra	15587(Tax:10090)	11787(Tax:10090)	Gene	Gene	CD3|compound|START_ENTITY CD3|compound|END_ENTITY	Zfra activates memory Hyal-2 + CD3 - CD19 - spleen cells to block cancer growth , stemness , and metastasis in vivo .
22016393	0	Hyaluronan_synthase_2	0,21	tissue_metalloproteinase_inhibitor_1	84,120	Hyaluronan synthase 2	tissue metalloproteinase inhibitor 1	3037	7076	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	Hyaluronan_synthase_2 -LRB- HAS2 -RRB- promotes breast_cancer cell invasion by suppression of tissue_metalloproteinase_inhibitor_1 -LRB- TIMP-1 -RRB- .
19820968	0	Hyperpolarization-activated_cyclic-nucleotide_gated_4	0,53	HCN4	55,59	Hyperpolarization-activated cyclic-nucleotide gated 4	HCN4	59266(Tax:10116)	59266(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Hyperpolarization-activated_cyclic-nucleotide_gated_4 -LRB- HCN4 -RRB- protein is expressed in a subset of rat dorsal root and trigeminal ganglion neurons .
23907424	0	Hyperpolarization-activated_cyclic_nucleotide-gated_2	0,53	HCN2	55,59	Hyperpolarization-activated cyclic nucleotide-gated 2	HCN2	610	610	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Hyperpolarization-activated_cyclic_nucleotide-gated_2 -LRB- HCN2 -RRB- polymorphism is associated with chronic inflammatory_periodontitis .
8878108	0	Hypoxanthine-guanine_phosphoribosyltransferase	0,46	HPRT	48,52	Hypoxanthine-guanine phosphoribosyltransferase	HPRT	15452(Tax:10090)	15452(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- expression in the central nervous system of HPRT-deficient mice following adenoviral-mediated gene transfer .
1196424	0	Hypoxanthine_guanine_phosphoribosyltransferase	0,46	HGPRT	48,53	Hypoxanthine guanine phosphoribosyltransferase	HGPRT	15452(Tax:10090)	15452(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Hypoxanthine_guanine_phosphoribosyltransferase -LRB- HGPRT -RRB- activity in hybrids derived from HGPRT + and HGPRT - mouse cells .
26964091	0	Hypoxia-Inducible_Factor-1a	76,103	PIN1	38,42	Hypoxia-Inducible Factor-1a	PIN1	3091	5300	Gene	Gene	Binds|nmod|START_ENTITY Binds|compound|END_ENTITY	Correction : Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible_Factor-1a .
23594994	0	Hypoxia-Inducible_Factor_1a	33,60	HIF-1a	62,68	Hypoxia-Inducible Factor 1a	HIF-1a	3091	3091	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	MiR199b Suppresses Expression of Hypoxia-Inducible_Factor_1a -LRB- HIF-1a -RRB- in Prostate_Cancer Cells .
23594994	0	Hypoxia-Inducible_Factor_1a	33,60	MiR199b	0,7	Hypoxia-Inducible Factor 1a	MiR199b	3091	406978	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	MiR199b Suppresses Expression of Hypoxia-Inducible_Factor_1a -LRB- HIF-1a -RRB- in Prostate_Cancer Cells .
26707870	0	Hypoxia-inducible_Factor-2_Alpha	71,103	Programmed_Death-ligand_1	21,46	Hypoxia-inducible Factor-2 Alpha	Programmed Death-ligand 1	2034	29126	Gene	Gene	Target|nmod|START_ENTITY END_ENTITY|appos|Target	Renal_Cell_Carcinoma Programmed_Death-ligand_1 , a New Direct Target of Hypoxia-inducible_Factor-2_Alpha , is Regulated by von_Hippel-Lindau Gene Mutation Status .
17374610	0	Hypoxia-inducible_factor-1	0,26	TrkB	73,77	Hypoxia-inducible factor-1	TrkB	3091	4915	Gene	Gene	activator|nsubj|START_ENTITY activator|nmod|gene gene|compound|END_ENTITY	Hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- is a transcriptional activator of the TrkB neurotrophin receptor gene .
18339868	0	Hypoxia-inducible_factor-1	0,26	vascular_endothelial_growth_factor	82,116	Hypoxia-inducible factor-1	vascular endothelial growth factor	3091	7422	Gene	Gene	genes|amod|START_ENTITY genes|nmod|response response|nmod|inhibition inhibition|compound|END_ENTITY	Hypoxia-inducible_factor-1 target genes as indicators of tumor vessel response to vascular_endothelial_growth_factor inhibition .
22036844	0	Hypoxia-inducible_factor-1_a	0,28	prion_protein	39,52	Hypoxia-inducible factor-1 a	prion protein	3091	5621	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Hypoxia-inducible_factor-1_a regulates prion_protein expression to protect against neuron cell damage .
15265376	0	Hypoxia-inducible_factor-1_alpha	0,32	vascular_endothelial_growth_factor	55,89	Hypoxia-inducible factor-1 alpha	vascular endothelial growth factor	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|role role|nmod|END_ENTITY	Hypoxia-inducible_factor-1_alpha regulates the role of vascular_endothelial_growth_factor on pulmonary arteries of rats with hypoxia-induced pulmonary_hypertension .
25807177	0	Hypoxia-inducible_factor-1a	0,27	ERRy	106,110	Hypoxia-inducible factor-1a	ERRy	3091	2104	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|END_ENTITY	Hypoxia-inducible_factor-1a upregulates tyrosine hydroxylase and dopamine_transporter by nuclear receptor ERRy in SH-SY5Y cells .
24803010	0	Hypoxia-inducible_factor-1a	0,27	HIF-1a	29,35	Hypoxia-inducible factor-1a	HIF-1a	3091	3091	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression in placentae of women with iron_deficiency_anemia_and_b-thalassemia trait .
22114151	0	Hypoxia-inducible_factor-1a	0,27	KCNMB1	38,44	Hypoxia-inducible factor-1a	KCNMB1	3091	3779	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Hypoxia-inducible_factor-1a regulates KCNMB1 expression in human pulmonary artery smooth muscle cells .
23667251	0	Hypoxia-inducible_factor-1a	0,27	eIF4E1	131,137	Hypoxia-inducible factor-1a	eIF4E1	3091	1977	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast_cancer cells under hypoxia conditions .
22843691	0	Hypoxia-inducible_factor-1a	0,27	transient_receptor_potential_ankyrin_repeat_1	48,93	Hypoxia-inducible factor-1a	transient receptor potential ankyrin repeat 1	3091	8989	Gene	Gene	switches|nsubj|START_ENTITY switches|nmod|END_ENTITY	Hypoxia-inducible_factor-1a -LRB- HIF1a -RRB- switches on transient_receptor_potential_ankyrin_repeat_1 -LRB- TRPA1 -RRB- gene expression via a hypoxia response element-like motif to modulate cytokine release .
21224490	0	Hypoxia-inducible_factor-1alpha	0,31	haptoglobin	41,52	Hypoxia-inducible factor-1alpha	haptoglobin	3091	3240	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Hypoxia-inducible_factor-1alpha enhances haptoglobin gene expression by improving binding of STAT3 to the promoter .
18588890	0	Hypoxia-inducible_factor-1alpha	0,31	matrix_metalloproteinase-1	42,68	Hypoxia-inducible factor-1alpha	matrix metalloproteinase-1	3091	4312	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Hypoxia-inducible_factor-1alpha regulates matrix_metalloproteinase-1 activity in human bone marrow-derived mesenchymal stem cells .
22452996	0	Hypoxia-inducible_factor-2a	0,27	ABCG2	47,52	Hypoxia-inducible factor-2a	ABCG2	2034	9429	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	Hypoxia-inducible_factor-2a is associated with ABCG2 expression , histology-grade and Ki67 expression in breast_invasive_ductal_carcinoma .
21765015	0	Hypoxia-inducible_factor-2a	0,27	vascular_endothelial_growth_factor	61,95	Hypoxia-inducible factor-2a	vascular endothelial growth factor	13819(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Hypoxia-inducible_factor-2a regulates GM-CSF-derived soluble vascular_endothelial_growth_factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis .
18356544	0	Hypoxia-inducible_factor-2alpha	0,31	Abcg2	47,52	Hypoxia-inducible factor-2alpha	Abcg2	13819(Tax:10090)	26357(Tax:10090)	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	Hypoxia-inducible_factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells .
18544564	0	Hypoxia-inducible_factor-2alpha	0,31	DR5	75,78	Hypoxia-inducible factor-2alpha	DR5	2034	8795	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Hypoxia-inducible_factor-2alpha regulates the expression of TRAIL receptor DR5 in renal_cancer cells .
25587023	0	Hypoxia-inducible_factor_1	0,26	TAZ	36,39	Hypoxia-inducible factor 1	TAZ	3091	6901	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Hypoxia-inducible_factor_1 mediates TAZ expression and nuclear localization to induce the breast_cancer stem cell phenotype .
12499918	0	Hypoxia-inducible_factor_1	0,26	vascular_endothelial_growth_factor	37,71	Hypoxia-inducible factor 1	vascular endothelial growth factor	3091	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Hypoxia-inducible_factor_1 regulates vascular_endothelial_growth_factor expression in human pancreatic_cancer .
25432699	0	Hypoxia-inducible_factor_1-alpha	0,32	phospholipase_D2	64,80	Hypoxia-inducible factor 1-alpha	phospholipase D2	3091	5338	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Hypoxia-inducible_factor_1-alpha up-regulates the expression of phospholipase_D2 in colon_cancer cells under hypoxic conditions .
17502379	0	Hypoxia-inducible_factor_1alpha	0,31	mammalian_target_of_rapamycin	52,81	Hypoxia-inducible factor 1alpha	mammalian target of rapamycin	3091	2475	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Hypoxia-inducible_factor_1alpha is regulated by the mammalian_target_of_rapamycin -LRB- mTOR -RRB- via an mTOR signaling motif .
15175080	0	Hypoxia-inducible_factor_1alpha	0,31	vascular_endothelial_growth_factor	32,66	Hypoxia-inducible factor 1alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Hypoxia-inducible_factor_1alpha / vascular_endothelial_growth_factor axis in astrocytomas .
17322295	0	Hypoxia-inducible_factor_2alpha	0,31	frataxin	102,110	Hypoxia-inducible factor 2alpha	frataxin	13819(Tax:10090)	14297(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Hypoxia-inducible_factor_2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin .
18434321	0	Hypoxia-inducible_transcription_factor-2alpha	0,45	ephrin_A1	124,133	Hypoxia-inducible transcription factor-2alpha	ephrin A1	13819(Tax:10090)	13636(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Hypoxia-inducible_transcription_factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin_A1 .
25976178	0	Hypoxia_Inducible_Factor-1a	112,139	Notch	72,77	Hypoxia Inducible Factor-1a	Notch	29560(Tax:10116)	25496(Tax:10116)	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|compound|END_ENTITY	Electroacupuncture Pretreatment Attenuates Cerebral_Ischemic_Injury via Notch Pathway-Mediated Up-Regulation of Hypoxia_Inducible_Factor-1a in Rats .
25833522	0	Hypoxia_Inducible_Factor-1alpha	15,46	HIF-1a	48,54	Hypoxia Inducible Factor-1alpha	HIF-1a	3091	3091	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	The Changes by Hypoxia_Inducible_Factor-1alpha -LRB- HIF-1a -RRB- on Taurine Uptake in Brain Capillary Endothelial Cells at High Glucose Conditions .
25093297	0	Hypoxia_inducible_factor-1a	0,27	Peroxiredoxin_3	39,54	Hypoxia inducible factor-1a	Peroxiredoxin 3	3091	10935	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Hypoxia_inducible_factor-1a suppresses Peroxiredoxin_3 expression to promote proliferation of CCRCC cells .
24599003	0	Hypoxia_inducible_factor-1a	0,27	clusterin	55,64	Hypoxia inducible factor-1a	clusterin	3091	1191	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Hypoxia_inducible_factor-1a directly regulates nuclear clusterin transcription by interacting with hypoxia response elements in the clusterin promoter .
21533547	0	Hypoxia_inducible_factor-1a	0,27	receptor_activator_of_nuclear_factor-kB_ligand	63,109	Hypoxia inducible factor-1a	receptor activator of nuclear factor-kB ligand	3091	8600	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Hypoxia_inducible_factor-1a directly induces the expression of receptor_activator_of_nuclear_factor-kB_ligand in periodontal ligament fibroblasts .
16555123	0	Hypoxia_inducible_factor-1alpha	0,31	VEGF-C	48,54	Hypoxia inducible factor-1alpha	VEGF-C	3091	7424	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|expression expression|amod|END_ENTITY	Hypoxia_inducible_factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast_cancer .
16136272	0	Hypoxia_inducible_factor_1-alpha	0,32	platelet_derived_growth_factor-B	46,78	Hypoxia inducible factor 1-alpha	platelet derived growth factor-B	3091	5155	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Hypoxia_inducible_factor_1-alpha regulates of platelet_derived_growth_factor-B in human glioblastoma cells .
20624301	0	Hypoxia_inducible_factor_1alpha	0,31	HIF-1alpha	38,48	Hypoxia inducible factor 1alpha	HIF-1alpha	3091	3091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hypoxia_inducible_factor_1alpha gene -LRB- HIF-1alpha -RRB- splice variants : potential prognostic biomarkers in breast_cancer .
21402775	0	Hzf	45,48	p53	60,63	Hzf	p53	25946	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|compound|END_ENTITY	Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation .
9469461	0	I-309	77,82	CCR8	18,22	I-309	CCR8	6346	1237	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	Identification of CCR8 as the specific receptor for the human beta-chemokine I-309 : cloning and molecular characterization of murine CCR8 as the receptor for TCA-3 .
14770367	0	I-BABP	41,47	ileal_bile_acid-binding_protein	8,39	I-BABP	ileal bile acid-binding protein	2172	2172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Is the ileal_bile_acid-binding_protein -LRB- I-BABP -RRB- gene involved in cholesterol homeostasis ? -RSB- .
21204605	0	I-FABP	127,133	intestinal_fatty_acid-binding_protein	88,125	I-FABP	intestinal fatty acid-binding protein	2169	2169	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Development of a high-specificity sandwich ELISA system for the quantification of human intestinal_fatty_acid-binding_protein -LRB- I-FABP -RRB- concentrations .
15122750	0	I-TAC	31,36	CXCR3	18,23	I-TAC	CXCR3	6373	2833	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the CXCR3 ligand I-TAC by hepatocytes in chronic hepatitis_C and its correlation with hepatic_inflammation .
24398292	0	I-TAC	24,29	Cxcl11	31,37	I-TAC	Cxcl11	56066(Tax:10090)	56066(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Epidermal expression of I-TAC -LRB- Cxcl11 -RRB- instructs adaptive Th2-type immunity .
11795279	0	I-TAC	80,85	IFN-gamma	108,117	I-TAC	IFN-gamma	6373	3458	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Lysophosphatidylcholine inhibits T cell-specific CXC chemokines IP-10 , MIG , and I-TAC expression induced by IFN-gamma in human endothelial cells .
11896933	0	I-TAC	72,77	interferon-inducible_T_cell_alpha_chemokine	27,70	I-TAC	interferon-inducible T cell alpha chemokine	56066(Tax:10090)	56066(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	IFN-gamma regulates murine interferon-inducible_T_cell_alpha_chemokine -LRB- I-TAC -RRB- expression in dendritic cell lines and during experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
20123020	0	I-kappa-Balpha	94,108	protein_tyrosine_phosphatase_1B	14,45	I-kappa-Balpha	protein tyrosine phosphatase 1B	4792	5770	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	NGF-activated protein_tyrosine_phosphatase_1B mediates the phosphorylation and degradation of I-kappa-Balpha coupled to NF-kappa-B activation , thereby controlling dendrite morphology .
18950638	0	I-kappaBbeta	54,66	NF-kappaB	30,39	I-kappaBbeta	NF-kappaB	4793	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|mechanism mechanism|nmod|END_ENTITY	A new regulatory mechanism of NF-kappaB activation by I-kappaBbeta in cancer cells .
12944466	0	I-mfa	10,15	HIC	43,46	I-mfa	HIC	4188	29969	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The human I-mfa domain-containing protein , HIC , interacts with cyclin_T1 and modulates P-TEFb-dependent transcription .
15236752	0	IA-2	31,35	IFNgamma	53,61	IA-2	IFNgamma	5798	3458	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased in vivo frequency of IA-2 peptide-reactive IFNgamma + / IL-4 - T cells in type 1 diabetic subjects .
10909970	0	IA-2	50,54	INS-1	58,63	IA-2	INS-1	5798	2305	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|beta-cells beta-cells|amod|pancreatic pancreatic|amod|END_ENTITY	Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells .
12239095	0	IA-2	94,98	INS-1	102,107	IA-2	INS-1	116660(Tax:10116)	24505(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Effect of proinflammatory cytokines on gene expression of the diabetes-associated autoantigen IA-2 in INS-1 cells .
17951542	0	IA-2	40,44	RESP18	0,6	IA-2	RESP18	5798	389075	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	RESP18 , a homolog of the luminal domain IA-2 , is found in dense core vesicles in pancreatic islet cells and is induced by high glucose .
15820770	0	IA-2	61,65	Vitamin_D-binding_protein	0,25	IA-2	Vitamin D-binding protein	5798	2638	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Vitamin_D-binding_protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes .
11086294	0	IA-2_and_phogrin	69,85	IDA-1	0,5	IA-2 and phogrin	IDA-1	5798	175807(Tax:6239)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	IDA-1 , a Caenorhabditis_elegans homolog of the diabetic autoantigens IA-2_and_phogrin , is expressed in peptidergic neurons in the worm .
16418280	0	IA-2beta	0,8	ghrelin	38,45	IA-2beta	ghrelin	19276(Tax:10090)	58991(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	IA-2beta , but not IA-2 , is induced by ghrelin and inhibits glucose-stimulated insulin secretion .
12697028	0	IA-2beta	166,174	islet-cell_antigen_512	123,145	IA-2beta	islet-cell antigen 512	5799	5798	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell_antigen_512 -LRB- IA-2 -RRB- and phogrin -LRB- IA-2beta -RRB- .
14506618	0	IA1	56,59	estrogen_receptor_alpha	19,42	IA1	estrogen receptor alpha	3642	2099	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Genetic effects of estrogen_receptor_alpha and collagen IA1 genes on the relationships of parathyroid_hormone and 25_hydroxyvitamin_D with bone_mineral_density in Caucasian women .
14562991	0	IA1	112,115	estrogen_receptor_alpha	75,98	IA1	estrogen receptor alpha	3642	2099	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Association and linkage disequilibrium analyses suggest genetic effects of estrogen_receptor_alpha and collagen IA1 genes on bone_mineral_density in Caucasian women .
17130560	0	IA2	52,55	MHC_class_I_chain-related_gene-A	0,32	IA2	MHC class I chain-related gene-A	5798	100507436	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	MHC_class_I_chain-related_gene-A is associated with IA2 and IAA but not GAD in Swedish type_1_diabetes_mellitus .
25794933	0	IAA-LEUCINE_RESISTANT3	53,75	bHLH104	30,37	IAA-LEUCINE RESISTANT3	bHLH104	835557(Tax:3702)	827086(Tax:3702)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	The bHLH Transcription Factor bHLH104 Interacts with IAA-LEUCINE_RESISTANT3 and Modulates Iron Homeostasis in Arabidopsis .
12833149	0	IAP	32,35	Inhibitor_of_apoptosis_protein	0,30	IAP	Inhibitor of apoptosis protein	84061	84061	Gene	Gene	survivin|appos|START_ENTITY survivin|amod|END_ENTITY	Inhibitor_of_apoptosis_protein -LRB- IAP -RRB- survivin is upregulated by oncogenic c-H-Ras .
22923192	0	IAP	32,35	Inhibitor_of_apoptosis_protein	0,30	IAP	Inhibitor of apoptosis protein	961	961	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Inhibitor_of_apoptosis_protein -LRB- IAP -RRB- antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy .
26247961	0	IAP	130,133	Intestinal_Alkaline_Phosphatase	97,128	IAP	Intestinal Alkaline Phosphatase	11648(Tax:10090)	11648(Tax:10090)	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	Partial Enteral Nutrition Preserves Elements of Gut Barrier Function , Including Innate Immunity , Intestinal_Alkaline_Phosphatase -LRB- IAP -RRB- Level , and Intestinal Microbiota in Mice .
26247961	0	IAP	130,133	Intestinal_Alkaline_Phosphatase	97,128	IAP	Intestinal Alkaline Phosphatase	11648(Tax:10090)	11648(Tax:10090)	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	Partial Enteral Nutrition Preserves Elements of Gut Barrier Function , Including Innate Immunity , Intestinal_Alkaline_Phosphatase -LRB- IAP -RRB- Level , and Intestinal Microbiota in Mice .
3210023	0	IAP	59,62	immunosuppressive_acidic_protein	25,57	IAP	immunosuppressive acidic protein	3375	3375	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Intrathecal synthesis of immunosuppressive_acidic_protein -LRB- IAP -RRB- in patients with multiple_sclerosis and other inflammatory neurological_diseases .
3772394	0	IAP	58,61	immunosuppressive_acidic_protein	24,56	IAP	immunosuppressive acidic protein	84061	84061	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Significant increase in immunosuppressive_acidic_protein -LRB- IAP -RRB- in serum of patients with multiple_sclerosis and other inflammatory neurological_disorders .
6727048	0	IAP	44,47	immunosuppressive_acidic_protein	10,42	IAP	immunosuppressive acidic protein	3375	3375	Gene	Gene	Study|appos|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study of immunosuppressive_acidic_protein -LRB- IAP -RRB- in patients with renal_cell_cancer -RSB- .
6749105	0	IAP	51,54	immunosuppressive_acidic_protein	17,49	IAP	immunosuppressive acidic protein	84061	84061	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	-LSB- Serum levels of immunosuppressive_acidic_protein -LRB- IAP -RRB- in various disease states and their clinical significance -RSB- .
23743278	0	IAP	68,71	inhibitor_of_apoptosis_protein	36,66	IAP	inhibitor of apoptosis protein	3375	3375	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Design , synthesis and evaluation of inhibitor_of_apoptosis_protein -LRB- IAP -RRB- antagonists that are highly selective for the BIR2 domain of XIAP .
10762341	0	IAP	42,45	integrin-associated_protein	13,40	IAP	integrin-associated protein	29364(Tax:10116)	29364(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of integrin-associated_protein -LRB- IAP -RRB- mRNA expression during memory consolidation in rat hippocampus .
2572523	0	IAP	36,39	islet-activating_protein	10,34	IAP	islet-activating protein	29364(Tax:10116)	29364(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of islet-activating_protein -LRB- IAP -RRB- on glucagon release from isolated perifused rat islets .
2695283	0	IAP	40,43	islet-activating_protein	14,38	IAP	islet-activating protein	29364(Tax:10116)	29364(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of islet-activating_protein -LRB- IAP -RRB- of pertussis toxin on the spontaneous diabetic_syndrome in the rat .
7030721	0	IAP	36,39	islet-activating_protein	10,34	IAP	islet-activating protein	3375	3375	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of islet-activating_protein -LRB- IAP -RRB- upon insulin secretion from human pancreatic islets .
11377392	0	IAP-1	26,31	Inhibitor_of_apoptosis-1	0,24	IAP-1	Inhibitor of apoptosis-1	330	330	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibitor_of_apoptosis-1 -LRB- IAP-1 -RRB- expression and apoptosis in non-small-cell lung_cancer cells exposed to gemcitabine .
16887350	0	IAP1	69,73	IKK_epsilon	0,11	IAP1	IKK epsilon	39753(Tax:7227)	35329(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	IKK_epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis .
8404688	0	IAPP	116,120	CGRP	79,83	IAPP	CGRP	3375	796	Gene	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	Molecular identification of binding sites for calcitonin gene-related peptide -LRB- CGRP -RRB- and islet amyloid polypeptide -LRB- IAPP -RRB- in mammalian lung : species variation and binding of truncated CGRP and IAPP .
10710286	0	IAPP	29,33	Chromogranin-B	0,14	IAPP	Chromogranin-B	15874(Tax:10090)	12653(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Chromogranin-B regulation of IAPP and insulin secretion .
18723083	0	IBSP	70,74	integrin-binding_sialoprotein	39,68	IBSP	integrin-binding sialoprotein	3381	3381	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Identification and characterization of integrin-binding_sialoprotein -LRB- IBSP -RRB- genes in reptile and amphibian .
15132839	0	ICAD	103,107	Bcl-2	68,73	ICAD	Bcl-2	1676	596	Gene	Gene	altering|dep|START_ENTITY altering|dobj|expression expression|nmod|END_ENTITY	Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2 / Bax and activating caspase-3 / ICAD pathway .
18274961	0	ICAM	109,113	LFA-1	103,108	ICAM	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Preclinical absorption , distribution , metabolism and excretion -LRB- ADME -RRB- characterization of ICAM1988 , an LFA-1 / ICAM antagonist , and its prodrug .
16004874	0	ICAM-1	69,75	A21	40,43	ICAM-1	A21	3383	28922	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of coxsackievirus A21 and its interaction with ICAM-1 .
17012252	0	ICAM-1	55,61	Alpha-synuclein	0,15	ICAM-1	Alpha-synuclein	3383	6622	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells .
26057873	0	ICAM-1	44,50	ApoM	0,4	ICAM-1	ApoM	3383	55937	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dobj|Expression	ApoM Suppresses TNF-a-Induced Expression of ICAM-1 and VCAM-1 Through Inhibiting the Activity of NF-kB .
20484595	0	ICAM-1	35,41	C5a	21,24	ICAM-1	C5a	3383	728	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells .
21391218	0	ICAM-1	14,20	CCN6	0,4	ICAM-1	CCN6	3383	8838	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells .
7679530	0	ICAM-1	48,54	CD-54	56,61	ICAM-1	CD-54	3383	3383	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The modulation of human aortic endothelial cell ICAM-1 -LRB- CD-54 -RRB- expression by serum containing high titers of anti-HLA antibodies .
16506060	0	ICAM-1	144,150	CD18	153,157	ICAM-1	CD18	3383	3689	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	The effects of intensive , moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 -LRB- ICAM-1 -RRB- , CD18 -LRB- beta2 integrin -RRB- and CD53 .
10342043	0	ICAM-1	43,49	CD4	52,55	ICAM-1	CD4	3383	920	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Soluble intercellular adhesion molecule-1 -LRB- ICAM-1 -RRB- , CD4 , CD8 and interleukin-2 receptor in patients with Beh __ et 's _ disease and Vogt-Koyanagi-Harada 's _ disease .
1347547	1	ICAM-1	164,170	CD4	88,91	ICAM-1	CD4	3383	920	Gene	Gene	pathway|compound|START_ENTITY mediated|nmod|pathway signal|acl|mediated require|dobj|signal require|nsubj|cells cells|compound|END_ENTITY	Naive CD4 +45 RA + T cells require a costimulatory signal mediated through the LFA-1 / ICAM-1 pathway .
1683685	0	ICAM-1	62,68	CD43	0,4	ICAM-1	CD43	3383	6693	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	CD43 , a molecule defective in Wiskott-Aldrich_syndrome , binds ICAM-1 .
19662219	0	ICAM-1	65,71	CD43	72,76	ICAM-1	CD43	3383	6693	Gene	Gene	Interaction|compound|START_ENTITY Interaction|compound|END_ENTITY	Induction of Proteases_in_Peritoneal_Carcinomatosis , the Role of ICAM-1 / CD43 Interaction .
10617927	0	ICAM-1	8,14	CD54	16,20	ICAM-1	CD54	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of ICAM-1 -LRB- CD54 -RRB- in the development of murine cerebral_malaria .
11243408	0	ICAM-1	45,51	CD54	53,57	ICAM-1	CD54	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human_parainfluenza_virus_type_3 upregulates ICAM-1 -LRB- CD54 -RRB- expression in a cytokine-independent manner .
11565953	0	ICAM-1	0,6	CD54	8,12	ICAM-1	CD54	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	ICAM-1 -LRB- CD54 -RRB- expression on T lymphocytes and natural killer cells from umbilical cord blood : regulation with interleukin-12 and interleukin-15 .
12660163	0	ICAM-1	14,20	CD54	22,26	ICAM-1	CD54	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p53 activates ICAM-1 -LRB- CD54 -RRB- expression in an NF-kappaB-independent manner .
14755544	0	ICAM-1	136,142	CD54	130,134	ICAM-1	CD54	3383	3383	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Recruitment and proliferation of T lymphocytes is supported by IFNgamma - and TNFalpha-activated human osteoblasts : Involvement of CD54 -LRB- ICAM-1 -RRB- and CD106 -LRB- VCAM-1 -RRB- adhesion molecules and CXCR3 chemokine receptor .
1671356	0	ICAM-1	30,36	CD54	38,42	ICAM-1	CD54	3383	3383	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the adhesion molecule ICAM-1 -LRB- CD54 -RRB- in staphylococcal enterotoxin-mediated cytotoxicity .
1973649	0	ICAM-1	32,38	CD54	40,44	ICAM-1	CD54	3383	3383	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of human thyroid cell ICAM-1 -LRB- CD54 -RRB- antigen expression and ICAM-1-mediated lymphocyte binding .
7516927	0	ICAM-1	14,20	CD54	22,26	ICAM-1	CD54	3383	3383	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Regulation of ICAM-1 -LRB- CD54 -RRB- expression in human breast_cancer cell lines by interleukin 6 and fibroblast-derived factors .
7531732	0	ICAM-1	53,59	CD54	64,68	ICAM-1	CD54	3383	3383	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Cetirizine reduces inflammatory cell recruitment and ICAM-1 -LRB- or CD54 -RRB- expression on conjunctival epithelium in both early - and late-phase reactions after allergen-specific challenge .
7538157	0	ICAM-1	32,38	CD54	40,44	ICAM-1	CD54	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of adhesion molecule ICAM-1 -LRB- CD54 -RRB- in thyroid papillary_adenocarcinoma .
7747416	0	ICAM-1	57,63	CD54	65,69	ICAM-1	CD54	3383	3383	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Early induction of interferon-independent virus-specific ICAM-1 -LRB- CD54 -RRB- expression by flavivirus in quiescent but not proliferating fibroblasts -- implications for virus-host interactions .
7912996	0	ICAM-1	0,6	CD54	8,12	ICAM-1	CD54	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	ICAM-1 -LRB- CD54 -RRB- expression on B lymphocytes is associated with their costimulatory function and can be increased by coactivation with IL-1 and IL-7 .
8105044	0	ICAM-1	33,39	CD54	27,31	ICAM-1	CD54	3383	3383	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of soluble CD54 -LRB- ICAM-1 -RRB- in human_immunodeficiency_virus_infection .
9766633	0	ICAM-1	80,86	CD54	88,92	ICAM-1	CD54	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-18 / interferon-gamma-inducing_factor , a novel cytokine , up-regulates ICAM-1 -LRB- CD54 -RRB- expression in KG-1 cells .
24556222	0	ICAM-1	52,58	COX-2	39,44	ICAM-1	COX-2	15894(Tax:10090)	17709(Tax:10090)	Gene	Gene	cytokines|dep|START_ENTITY cytokines|compound|END_ENTITY	Tinospora cordifolia extract modulates COX-2 , iNOS , ICAM-1 , pro-inflammatory cytokines and redox status in murine model of asthma .
9705828	0	ICAM-1	38,44	Cyclo-oxygenase-2	0,17	ICAM-1	Cyclo-oxygenase-2	3383	5743	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cyclo-oxygenase-2 regulates inducible ICAM-1 and VCAM-1 expression in human vascular smooth muscle cells .
1672137	0	ICAM-1	25,31	Cyclosporin_A	0,13	ICAM-1	Cyclosporin A	3383	1161	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Cyclosporin_A suppresses ICAM-1 expression by papillary endothelium in healing psoriatic plaques .
7813562	0	ICAM-1	80,86	DP-1904	0,7	ICAM-1	DP-1904	3383	2944390(Tax:177439)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	DP-1904 , a specific inhibitor of thromboxane_A2 synthesizing enzyme , suppresses ICAM-1 expression by stimulated vascular endothelial cells .
22546945	0	ICAM-1	93,99	Diacylglycerol_kinase_zeta	0,26	ICAM-1	Diacylglycerol kinase zeta	3383	8525	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Diacylglycerol_kinase_zeta negatively regulates CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow .
10754335	0	ICAM-1	72,78	E-selectin	24,34	ICAM-1	E-selectin	3383	6401	Gene	Gene	pathway|amod|START_ENTITY activates|nmod|pathway activates|nsubj|tethering tethering|nmod|END_ENTITY	Neutrophil tethering on E-selectin activates beta_2 integrin binding to ICAM-1 through a mitogen-activated protein kinase signal transduction pathway .
12911509	0	ICAM-1	31,37	E-selectin	8,18	ICAM-1	E-selectin	3383	6401	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Soluble E-selectin and soluble ICAM-1 levels as markers of the activity of atopic_dermatitis in children .
14603993	0	ICAM-1	12,18	E-selectin	28,38	ICAM-1	E-selectin	3383	6401	Gene	Gene	P-selectin|compound|START_ENTITY P-selectin|appos|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFalphaRII in patients with coronary_artery_disease .
15495786	0	ICAM-1	12,18	E-selectin	28,38	ICAM-1	E-selectin	3383	6401	Gene	Gene	P-selectin|compound|START_ENTITY P-selectin|appos|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFRII in patients with coronary_artery_disease .
16459323	0	ICAM-1	51,57	E-selectin	75,85	ICAM-1	E-selectin	15894(Tax:10090)	20339(Tax:10090)	Gene	Gene	rolling|nmod|START_ENTITY rolling|nmod|engagement engagement|nmod|END_ENTITY	Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin .
19184433	0	ICAM-1	60,66	E-selectin	76,86	ICAM-1	E-selectin	3383	6401	Gene	Gene	mediated|nmod|START_ENTITY mediated|parataxis|signaling signaling|nsubj|role role|nmod|END_ENTITY	Kinetics of LFA-1 mediated adhesion of human neutrophils to ICAM-1 -- role of E-selectin signaling post-activation .
25138157	0	ICAM-1	21,27	E-selectin	110,120	ICAM-1	E-selectin	3383	6401	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nmod|engagement engagement|nmod|CD44 CD44|nmod|END_ENTITY	Melanoma upregulates ICAM-1 expression on endothelial cells through engagement of tumor CD44 with endothelial E-selectin and activation of a PKCa-p38-SP-1 pathway .
7473588	0	ICAM-1	27,33	E-selectin	14,24	ICAM-1	E-selectin	3383	6401	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Inhibition of E-selectin - , ICAM-1 - , and VCAM-1-mediated cell adhesion by benzo -LSB- b -RSB- thiophene - , benzofuran - , indole - , and naphthalene-2-carboxamides : identification of PD_144795 as an antiinflammatory agent .
7570951	0	ICAM-1	12,18	E-selectin	20,30	ICAM-1	E-selectin	3383	6401	Gene	Gene	Circulating|dobj|START_ENTITY class|advcl|Circulating class|nsubj|END_ENTITY	Circulating ICAM-1 , E-selectin , IL-2_receptor , and HLA class I in human small bowel , liver , and small bowel-plus-liver transplant recipients .
7686390	0	ICAM-1	47,53	E-selectin	56,66	ICAM-1	E-selectin	3383	6401	Gene	Gene	adhesion|dep|START_ENTITY adhesion|amod|END_ENTITY	Circulating intercellular adhesion molecule-1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in human malignancies .
9133922	0	ICAM-1	54,60	E-selectin	78,88	ICAM-1	E-selectin	3383	6401	Gene	Gene	VCAM-1|compound|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
9434632	0	ICAM-1	63,69	E-selectin	8,18	ICAM-1	E-selectin	3383	6401	Gene	Gene	expression|appos|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Soluble E-selectin enhances intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human tumor cell lines .
9888481	0	ICAM-1	47,53	E-selectin	56,66	ICAM-1	E-selectin	3383	6401	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|amod|END_ENTITY	Circulating intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in head_and_neck_cancer .
26185364	0	ICAM-1	70,76	Ets-Like_Transcription_Factor_1	20,51	ICAM-1	Ets-Like Transcription Factor 1	3383	1999	Gene	Gene	Expression|compound|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	Epithelium-Specific Ets-Like_Transcription_Factor_1 , ESE-1 , Regulates ICAM-1 Expression in Cultured Lung Epithelial Cell Lines .
25786691	0	ICAM-1	48,54	FOXO1	0,5	ICAM-1	FOXO1	15894(Tax:10090)	56458(Tax:10090)	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	FOXO1 Regulates Dendritic Cell Activity through ICAM-1 and CCR7 .
10903502	0	ICAM-1	29,35	Fibrinogen	0,10	ICAM-1	Fibrinogen	3383	2244	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Fibrinogen interactions with ICAM-1 -LRB- CD54 -RRB- regulate endothelial cell survival .
1378365	0	ICAM-1	153,159	GMP-140	105,112	ICAM-1	GMP-140	3383	6403	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Adhesion molecule expression in Graves ' thyroid glands ; potential relevance of granule membrane protein -LRB- GMP-140 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the homing and antigen presentation processes .
10072876	0	ICAM-1	15,21	HCC	30,33	ICAM-1	HCC	3383	619501	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	-LSB- Expression of ICAM-1 mRNA in HCC using in situ hybridization technique -RSB- .
12506144	0	ICAM-1	24,30	ICAM-1	64,70	ICAM-1	ICAM-1	3383	3383	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts .
12506144	0	ICAM-1	64,70	ICAM-1	24,30	ICAM-1	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Selective regulation of ICAM-1 and RANTES gene expression after ICAM-1 ligation on human renal fibroblasts .
7955542	0	ICAM-1	168,174	ICAM-1	66,72	ICAM-1	ICAM-1	3383	3383	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression and soluble ICAM-1 -LRB- sICAM-1 -RRB- production by cytokine-activated human aortic endothelial cells : a possible role for ICAM-1 and sICAM-1 in atherosclerotic_aortic_aneurysms .
7955542	0	ICAM-1	66,72	ICAM-1	168,174	ICAM-1	ICAM-1	3383	3383	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression and soluble ICAM-1 -LRB- sICAM-1 -RRB- production by cytokine-activated human aortic endothelial cells : a possible role for ICAM-1 and sICAM-1 in atherosclerotic_aortic_aneurysms .
16920492	0	ICAM-1	14,20	ICAM-3	69,75	ICAM-1	ICAM-3	3383	3385	Gene	Gene	Engagement|nmod|START_ENTITY activates|nsubj|Engagement activates|dobj|pathway pathway|compound|END_ENTITY	Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1 / ICAM-3 cell adhesion pathway in mononuclear phagocytes .
9133922	0	ICAM-1	54,60	ICAM-3	62,68	ICAM-1	ICAM-3	3383	3385	Gene	Gene	VCAM-1|compound|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
16552819	0	ICAM-1	14,20	IFN-alpha	98,107	ICAM-1	IFN-alpha	3383	3439	Gene	Gene	Expression|nmod|START_ENTITY induced|nsubj|Expression induced|nmod|END_ENTITY	Expression of ICAM-1 , HLA-DR , and CD80 on peripheral circulating CD1 alpha DCs induced in vivo by IFN-alpha in patients with chronic_hepatitis_B .
7740833	0	ICAM-1	13,19	IFN-gamma	45,54	ICAM-1	IFN-gamma	3383	3458	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of ICAM-1 and HLA-DR expression by IFN-gamma in malignant_melanoma cell lines .
10936510	0	ICAM-1	55,61	IL-1	77,81	ICAM-1	IL-1	3383	3552	Gene	Gene	START_ENTITY|nmod|response response|nmod|stimulation stimulation|compound|END_ENTITY	Santonin-related compound 2 inhibits the expression of ICAM-1 in response to IL-1 stimulation by blocking the signaling pathway upstream of I kappa B degradation .
10427988	0	ICAM-1	108,114	IL-10	46,51	ICAM-1	IL-10	3383	3586	Gene	Gene	results|nmod|START_ENTITY results|nmod|END_ENTITY	Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1 , ICAM-2 or ICAM-3 .
11122238	0	ICAM-1	161,167	IL-10	99,104	ICAM-1	IL-10	15894(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY modulation|nmod|expression END_ENTITY|nmod|modulation	Roles of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , transforming growth factor-beta -LRB- TGF-beta -RRB- , and IL-10 in the modulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by macrophages during mycobacterial_infection .
24103557	0	ICAM-1	0,6	IL-10	110,115	ICAM-1	IL-10	15894(Tax:10090)	16153(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY exacerbates|nsubj|deficiency exacerbates|dobj|granulomatosis granulomatosis|acl|induced induced|nmod|production production|compound|END_ENTITY	ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium_acnes through impaired IL-10 production by regulatory T cells .
9808340	0	ICAM-1	15,21	IL-10	0,5	ICAM-1	IL-10	3383	3586	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-10 inhibits ICAM-1 expression on human Langerhans cells but not on keratinocytes , dermal endothelial cells or fibroblasts .
10554406	0	ICAM-1	20,26	IL-17	11,16	ICAM-1	IL-17	3383	3605	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	-LSB- Effect of IL-17 on ICAM-1 expression of human bronchial epithelial cells , NCI-H 292 -RSB- .
11882913	0	ICAM-1	18,24	IL-18	68,73	ICAM-1	IL-18	3383	3606	Gene	Gene	role|nmod|START_ENTITY role|dep|interaction interaction|nmod|effect effect|nmod|END_ENTITY	Essential role of ICAM-1 / LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC .
15614043	0	ICAM-1	84,90	IL-18	60,65	ICAM-1	IL-18	3383	3606	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes .
15618295	0	ICAM-1	101,107	IL-18	77,82	ICAM-1	IL-18	3383	3606	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|LFA703 LFA703|nmod|production production|nmod|END_ENTITY	Differential effect of LFA703 , pravastatin , and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes .
9177607	0	ICAM-1	57,63	IL-2R	102,107	ICAM-1	IL-2R	3383	3559	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Circulating levels of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and soluble interleukin_2_receptors -LRB- IL-2R -RRB- in patients with B cell chronic_lymphocytic_leukaemia .
26666474	0	ICAM-1	15,21	IL-33	0,5	ICAM-1	IL-33	15894(Tax:10090)	77125(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	IL-33 promotes ICAM-1 expression via NF-kB in murine mast cells .
10409231	0	ICAM-1	13,19	IL-4	0,4	ICAM-1	IL-4	3383	3565	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-4 induces ICAM-1 expression in human bronchial epithelial cells and potentiates TNF-alpha .
1347050	0	ICAM-1	14,20	IL-4	76,80	ICAM-1	IL-4	3383	3565	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression fibroblasts|nsubj|Regulation fibroblasts|nmod|END_ENTITY	Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4 .
1349767	0	ICAM-1	45,51	IL-4	0,4	ICAM-1	IL-4	3383	3565	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	IL-4 decreases IFN-gamma-induced endothelial ICAM-1 expression by a transcriptional mechanism .
1362565	0	ICAM-1	176,182	IL-4	97,101	ICAM-1	IL-4	15894(Tax:10090)	16189(Tax:10090)	Gene	Gene	interactions|nmod|START_ENTITY regulated|nmod|interactions regulated|nsubjpass|production production|compound|END_ENTITY	Antigen presentation by murine splenic , but not hepatic , antigen-presenting_cells to induce IL-2 / IL-4 production from immune T cells is regulated by interactions between LFA-1 / ICAM-1 .
22939995	0	ICAM-1	14,20	IL-6	0,4	ICAM-1	IL-6	3383	3569	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma .
7491556	0	ICAM-1	32,38	IL-8	66,70	ICAM-1	IL-8	3383	3576	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Role of elevated plasma soluble ICAM-1 and bronchial lavage fluid IL-8 levels as markers of chronic_lung_disease in premature infants .
12566693	0	ICAM-1	39,45	IgA_nephropathy	77,92	ICAM-1	IgA nephropathy	3383	60498	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Tubular and interstitial expression of ICAM-1 as a marker of renal_injury in IgA_nephropathy .
26897511	0	ICAM-1	67,73	Intercellular_Adhesion_Molecule_1	32,65	ICAM-1	Intercellular Adhesion Molecule 1	3383	3383	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of Polymorphisms in Intercellular_Adhesion_Molecule_1 -LRB- ICAM-1 -RRB- Gene with Cancer Susceptibility : A Meta-Analysis of 14 Case-Control Studies .
12027924	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	3383	3383	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- polymorphism is associated with diabetic_retinopathy in Type_2_diabetes_mellitus .
12783117	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is upregulated by thrombin in human monocytes and THP-1 cells in vitro and in pregnant subjects in vivo .
1351874	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by lymph node dendritic cells : comparison with epidermal Langerhans cells .
17990298	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy .
1968316	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is upregulated in autoimmune murine lupus_nephritis .
20422421	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphism and endometriosis in northern Iran .
23364881	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression correlates with oral_cancer progression and induces macrophage/cancer cell adhesion .
8938544	0	ICAM-1	35,41	Intercellular_adhesion_molecule-1	0,33	ICAM-1	Intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 ; CD54 -RRB- expression in human hepatocytic cells depends on protein kinase C. BACKGROUND/AIMS : Intracellular regulation of intercellular_adhesion_molecule-1 has mainly been studied in lymphoid , endothelial , and epithelial cells .
14621802	0	ICAM-1	35,41	Intercellular_adhesion_molecule_1	0,33	ICAM-1	Intercellular adhesion molecule 1	3383	3383	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- induction on hepatocytes is an early marker of acute liver allograft rejection .
15682683	0	ICAM-1	35,41	Intercellular_adhesion_molecule_1	0,33	ICAM-1	Intercellular adhesion molecule 1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene variant is associated with coronary_artery_calcification independent of soluble ICAM-1 levels .
10573217	0	ICAM-1	59,65	Interferon-gamma	0,16	ICAM-1	Interferon-gamma	3383	3458	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Interferon-gamma and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts .
7905278	0	ICAM-1	149,155	Interferon-gamma	0,16	ICAM-1	Interferon-gamma	3383	3458	Gene	Gene	expression|compound|START_ENTITY relation|nmod|expression concentration|dep|relation increases|dep|concentration increases|amod|END_ENTITY	Interferon-gamma increases cellular calcium ion concentration and inositol_1 ,4,5 - trisphosphate formation in human renal_carcinoma cells : relation to ICAM-1 antigen expression .
8645468	0	ICAM-1	110,116	Interferon-gamma	0,16	ICAM-1	Interferon-gamma	3383	3458	Gene	Gene	enhancement|compound|START_ENTITY independent|nmod|enhancement inositol_phosphate|xcomp|independent inositol_phosphate|nsubj|increases increases|amod|END_ENTITY	Interferon-gamma increases inositol_phosphate formation and cellular calcium ion concentration independent of ICAM-1 antigen enhancement in renal tubular cells .
9409637	0	ICAM-1	116,122	Interferon-gamma	0,16	ICAM-1	Interferon-gamma	3383	3458	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- down-regulates the rhinovirus-induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on human airway epithelial cells .
20432452	0	ICAM-1	26,32	Interleukin-1beta	0,17	ICAM-1	Interleukin-1beta	3383	3553	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid_arthritis synovial fibroblasts : involvement of ERK , JNK , AP-1 , and NF-kappaB .
12600107	0	ICAM-1	56,62	JNK/SAPK	16,24	ICAM-1	JNK/SAPK	3383	5599;5601	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|activity activity|compound|END_ENTITY	-LSB- Correlation of JNK/SAPK activity and the production of ICAM-1 on renal mesangial cells in vitro -RSB- .
8933279	0	ICAM-1	27,33	L-selectin	51,61	ICAM-1	L-selectin	15894(Tax:10090)	20343(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune_insulitis of NOD mice and association with both Th1 - and Th2-type infiltrates .
9133922	0	ICAM-1	54,60	L-selectin	90,100	ICAM-1	L-selectin	3383	6402	Gene	Gene	VCAM-1|compound|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
10195438	0	ICAM-1	84,90	LFA-1	64,69	ICAM-1	LFA-1	3383	3683	Gene	Gene	adhesion|compound|START_ENTITY inhibitor|nmod|adhesion peptide|dep|inhibitor peptide|acl|derived derived|nmod|alpha-subunit alpha-subunit|nmod|END_ENTITY	A Ca2 + binding cyclic peptide derived from the alpha-subunit of LFA-1 : inhibitor of ICAM-1 / LFA-1-mediated T-cell adhesion .
10233694	0	ICAM-1	100,106	LFA-1	94,99	ICAM-1	LFA-1	3383	3683	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA-1 / ICAM-1 pathway .
10375080	0	ICAM-1	109,115	LFA-1	116,121	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	VLA-4|compound|START_ENTITY VLA-4|dep|END_ENTITY	Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1 / LFA-1 and VCAM-1 / VLA-4 .
10556544	0	ICAM-1	49,55	LFA-1	56,61	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	assay|nmod|START_ENTITY Development|nmod|assay Development|parataxis|using using|nsubj|interactions interactions|compound|END_ENTITY	Development of a cell-free binding assay for rat ICAM-1 / LFA-1 interactions using a novel anti-rat LFA-1 monoclonal antibody and comparison with a cell-based assay .
10556544	0	ICAM-1	49,55	LFA-1	98,103	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	assay|nmod|START_ENTITY Development|nmod|assay Development|parataxis|using using|dobj|antibody antibody|compound|END_ENTITY	Development of a cell-free binding assay for rat ICAM-1 / LFA-1 interactions using a novel anti-rat LFA-1 monoclonal antibody and comparison with a cell-based assay .
10835320	0	ICAM-1	10,16	LFA-1	17,22	ICAM-1	LFA-1	3383	3683	Gene	Gene	START_ENTITY|parataxis|altered altered|nsubj|mediates mediates|compound|END_ENTITY	Intrinsic ICAM-1 / LFA-1 activation mediates altered responsiveness of atopic asthmatic airway_smooth_muscle .
10836363	0	ICAM-1	97,103	LFA-1	91,96	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	Induction|parataxis|START_ENTITY Induction|nmod|END_ENTITY	Induction of unresponsiveness to islet xenograft by MMC treatment of graft and blockage of LFA-1 / ICAM-1 pathway .
10861083	0	ICAM-1	49,55	LFA-1	4,9	ICAM-1	LFA-1	3383	3689	Gene	Gene	adhesions|nmod|START_ENTITY supports|dobj|adhesions supports|nsubj|integrin integrin|compound|END_ENTITY	The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment .
10998349	0	ICAM-1	56,62	LFA-1	147,152	ICAM-1	LFA-1	3383	3683	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY domain|nmod|intercellular_adhesion_molecule-1 maintains|nsubj|domain maintains|dobj|integrity integrity|nmod|site site|appos|END_ENTITY	The second domain of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- maintains the structural integrity of the leucocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- ligand-binding site in the first domain .
11327603	0	ICAM-1	58,64	LFA-1	52,57	ICAM-1	LFA-1	3383	3683	Gene	Gene	antagonists|compound|START_ENTITY /|dobj|antagonists /|nsubj|Discovery Discovery|nmod|END_ENTITY	Discovery and SAR of diarylsulfide_cyclopropylamide LFA-1 / ICAM-1 interaction antagonists .
11590197	0	ICAM-1	72,78	LFA-1	79,84	ICAM-1	LFA-1	3383	3683	Gene	Gene	VLA-4|compound|START_ENTITY VLA-4|dep|END_ENTITY	Differential regulation of transendothelial migration of THP-1 cells by ICAM-1 / LFA-1 and VCAM-1 / VLA-4 .
11786177	0	ICAM-1	75,81	LFA-1	69,74	ICAM-1	LFA-1	3383	3683	Gene	Gene	interaction|nsubj|START_ENTITY activity|parataxis|interaction activity|nmod|END_ENTITY	Synergistic inhibitory activity of alpha - and beta-LFA-1 peptides on LFA-1 / ICAM-1 interaction .
11800139	0	ICAM-1	14,20	LFA-1	8,13	ICAM-1	LFA-1	3383	3683	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|compound|END_ENTITY	Role of LFA-1 / ICAM-1 , CLA/E-selectin and VLA-4 / VCAM-1 pathways in recruiting leukocytes to the various regions of the chronic leg ulcer .
11834174	0	ICAM-1	15,21	LFA-1	22,27	ICAM-1	LFA-1	3383	3683	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	-LSB- Expression of ICAM-1 / LFA-1 in the pocket area of adult_periodontitis -RSB- .
11834839	0	ICAM-1	57,63	LFA-1	17,22	ICAM-1	LFA-1	3383	3683	Gene	Gene	immunoregulatory|compound|START_ENTITY transfer|nmod|immunoregulatory antagonist|nmod|transfer antagonist|compound|END_ENTITY	Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule .
11882913	0	ICAM-1	18,24	LFA-1	25,30	ICAM-1	LFA-1	3383	3683	Gene	Gene	role|nmod|START_ENTITY role|dep|interaction interaction|compound|END_ENTITY	Essential role of ICAM-1 / LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC .
11922836	0	ICAM-1	105,111	LFA-1	82,87	ICAM-1	LFA-1	3383	3683	Gene	Gene	inhibitor|nmod|START_ENTITY properties|dep|inhibitor properties|nmod|peptide peptide|nmod|I-domain I-domain|nmod|END_ENTITY	Structural and ICAM-1-docking properties of a cyclic peptide from the I-domain of LFA-1 : an inhibitor of ICAM-1 / LFA - _ 1-mediated T-cell adhesion .
11929876	0	ICAM-1	99,105	LFA-1	22,27	ICAM-1	LFA-1	3383	3689	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|activation activation|compound|END_ENTITY	Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in shear flow .
12454403	0	ICAM-1	29,35	LFA-1	23,28	ICAM-1	LFA-1	3383	3683	Gene	Gene	interaction|compound|START_ENTITY studies|dep|interaction studies|nmod|END_ENTITY	Comparative studies of LFA-1 / ICAM-1 interaction by micropipette and flow chamber techniques .
12643766	0	ICAM-1	85,91	LFA-1	23,28	ICAM-1	LFA-1	3383	3683	Gene	Gene	protein|compound|START_ENTITY modulates|nmod|protein protein|acl:relcl|modulates protein|compound|END_ENTITY	A peptide derived from LFA-1 protein that modulates T-cell adhesion binds to soluble ICAM-1 protein .
12659746	0	ICAM-1	71,77	LFA-1	78,83	ICAM-1	LFA-1	3383	3683	Gene	Gene	study|nmod|START_ENTITY study|parataxis|END_ENTITY	QSAR study on some p-arylthio_cinnamides as antagonists of biochemical ICAM-1 / LFA-1 interaction and ICAM-1 / JY-8 cell adhesion in relation to anti-inflammatory activity .
12732350	0	ICAM-1	10,16	LFA-1	17,22	ICAM-1	LFA-1	3383	3683	Gene	Gene	Targeting|dobj|START_ENTITY interaction|dep|Targeting interaction|compound|END_ENTITY	Targeting ICAM-1 / LFA-1 interaction for controlling autoimmune_diseases : designing peptide and small molecule inhibitors .
1346257	0	ICAM-1	49,55	LFA-1	80,85	ICAM-1	LFA-1	15894(Tax:10090)	3683	Gene	Gene	erythrocytes|dobj|START_ENTITY erythrocytes|nmod|site site|amod|distinct distinct|nmod|END_ENTITY	Plasmodium_falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1 , Mac-1 , and human rhinovirus .
1347547	1	ICAM-1	164,170	LFA-1	158,163	ICAM-1	LFA-1	3383	3683	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Naive CD4 +45 RA + T cells require a costimulatory signal mediated through the LFA-1 / ICAM-1 pathway .
1348286	0	ICAM-1	24,30	LFA-1	43,48	ICAM-1	LFA-1	3383	3683	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	Expression of the CD54 -LRB- ICAM-1 -RRB- and CD11a -LRB- LFA-1 -RRB- adhesion molecules in oral mucosal_inflammation .
1355751	0	ICAM-1	35,41	LFA-1	88,93	ICAM-1	LFA-1	3383	3683	Gene	Gene	Intercellular_adhesion_molecule-1|appos|START_ENTITY function-associated|nsubj|Intercellular_adhesion_molecule-1 function-associated|dobj|expression expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and leukocyte function-associated antigen-1 -LRB- LFA-1 -RRB- expression in human epiretinal membranes .
1358901	0	ICAM-1	32,38	LFA-1	26,31	ICAM-1	LFA-1	3383	3683	Gene	Gene	complex|compound|START_ENTITY contribution|dep|complex contribution|nmod|END_ENTITY	Force contribution of the LFA-1 / ICAM-1 complex to T cell adhesion .
14616784	0	ICAM-1	98,104	LFA-1	92,97	ICAM-1	LFA-1	3383	3683	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Transendothelial migration confers a survival advantage to activated T lymphocytes : role of LFA-1 / ICAM-1 interactions .
15058041	0	ICAM-1	70,76	LFA-1	11,16	ICAM-1	LFA-1	3383	3683	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of LFA-1 expression on neutrophils and serum level of soluble ICAM-1 in patients with chronic_myelogenous_leukemia -RSB- .
15109637	0	ICAM-1	72,78	LFA-1	66,71	ICAM-1	LFA-1	3383	3683	Gene	Gene	interaction|compound|START_ENTITY interaction|dep|1,3-oxazinan-2-ones 1,3-oxazinan-2-ones|nmod|inhibitors inhibitors|nmod|END_ENTITY	Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1 / ICAM-1 interaction : stabilization of the metabolically labile vanillyl side chain .
15142527	0	ICAM-1	6,12	LFA-1	0,5	ICAM-1	LFA-1	3383	3683	Gene	Gene	interaction|compound|START_ENTITY lowers|nsubj|interaction END_ENTITY|appos|lowers	LFA-1 / ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation .
15363150	0	ICAM-1	25,31	LFA-1	19,24	ICAM-1	LFA-1	3383	3683	Gene	Gene	signal|compound|START_ENTITY advance|dep|signal advance|nmod|END_ENTITY	-LSB- Recent advance on LFA-1 / ICAM-1 costimulatory signal of T cell-review -RSB- .
15582439	0	ICAM-1	149,155	LFA-1	143,148	ICAM-1	LFA-1	3383	3683	Gene	Gene	Amino-substituted_heterocycles|parataxis|START_ENTITY Amino-substituted_heterocycles|nmod|END_ENTITY	Amino-substituted_heterocycles as isosteres of trans-cinnamides : design and synthesis of heterocyclic_biaryl_sulfides as potent antagonists of LFA-1 / ICAM-1 binding .
16116032	0	ICAM-1	45,51	LFA-1	100,105	ICAM-1	LFA-1	3383	3683	Gene	Gene	express|xcomp|START_ENTITY express|parataxis|involved involved|nsubjpass|interactions interactions|compound|END_ENTITY	Germinal center dendritic cells express more ICAM-1 than extrafollicular dendritic cells and ICAM-1 / LFA-1 interactions are involved in the capacity of dendritic cells to induce PBMCs proliferation .
16250049	0	ICAM-1	86,92	LFA-1	93,98	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|dependent dependent|dep|END_ENTITY	Early intrahepatic antigen-specific retention of na ve CD8 + T cells is predominantly ICAM-1 / LFA-1 dependent in mice .
1672776	0	ICAM-1	26,32	LFA-1	62,67	ICAM-1	LFA-1	3383	3683	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|integrin integrin|compound|END_ENTITY	Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit .
1676615	0	ICAM-1	46,52	LFA-1	18,23	ICAM-1	LFA-1	3383	3683	Gene	Gene	cluster|compound|START_ENTITY cell-associated|dobj|cluster cell-associated|nsubj|END_ENTITY	B cell-associated LFA-1 and T cell-associated ICAM-1 transiently cluster in the area of contact between interacting cells .
1680610	0	ICAM-1	111,117	LFA-1	65,70	ICAM-1	LFA-1	3383	3683	Gene	Gene	leukocyte_function_associated_antigen-1|appos|START_ENTITY leukocyte_function_associated_antigen-1|appos|END_ENTITY	Increased expression of leukocyte_function_associated_antigen-1 -LRB- LFA-1 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by alveolar macrophages of patients with pulmonary_sarcoidosis .
1680920	0	ICAM-1	18,24	LFA-1	12,17	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY role|dep|interactions role|nmod|END_ENTITY	The role of LFA-1 / ICAM-1 interactions during murine T lymphocyte development .
1682230	0	ICAM-1	62,68	LFA-1	144,149	ICAM-1	LFA-1	3383	3683	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY expression|nmod|intercellular_adhesion_molecule_1 correlated|nsubj|expression correlated|nmod|infiltration infiltration|nmod|lymphocyte_function_associated_antigen_1 lymphocyte_function_associated_antigen_1|appos|END_ENTITY	Keratinocyte expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- correlated with infiltration of lymphocyte_function_associated_antigen_1 -LRB- LFA-1 -RRB- positive cells in evolving allergic_contact_dermatitis reactions .
16920492	0	ICAM-1	14,20	LFA-1	63,68	ICAM-1	LFA-1	3383	3683	Gene	Gene	Engagement|nmod|START_ENTITY activates|nsubj|Engagement activates|dobj|pathway pathway|compound|END_ENTITY	Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1 / ICAM-3 cell adhesion pathway in mononuclear phagocytes .
16923022	0	ICAM-1	42,48	LFA-1	61,66	ICAM-1	LFA-1	3383	3683	Gene	Gene	peptides|compound|START_ENTITY peptides|nmod|END_ENTITY	Characterization of binding properties of ICAM-1 peptides to LFA-1 : inhibitors of T-cell adhesion .
16937496	0	ICAM-1	31,37	LFA-1	64,69	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY receptors|nsubj|Expression receptors|xcomp|END_ENTITY	Expression and significance of ICAM-1 and its counter receptors LFA-1 and Mac-1 in experimental acute_pancreatitis of rats .
1707641	0	ICAM-1	59,65	LFA-1	66,71	ICAM-1	LFA-1	3383	3683	Gene	Gene	involvement|nmod|START_ENTITY Re-evaluation|nmod|involvement Re-evaluation|dep|END_ENTITY	Re-evaluation of the involvement of the adhesion molecules ICAM-1 / LFA-1 in syncytia formation of HIV-1-infected subclones of a CEM_T-cell_leukemic_line .
17868072	0	ICAM-1	0,6	LFA-1	76,81	ICAM-1	LFA-1	3383	3683	Gene	Gene	peptide|nsubj|START_ENTITY peptide|nmod|site site|nmod|END_ENTITY	ICAM-1 peptide inhibitors of T-cell adhesion bind to the allosteric site of LFA-1 .
18337659	0	ICAM-1	14,20	LFA-1	21,26	ICAM-1	LFA-1	3383	3683	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|prevents prevents|nsubj|interactions interactions|compound|END_ENTITY	Inhibition of ICAM-1 / LFA-1 interactions prevents B-cell-dependent anti-CD45RB-induced transplantation tolerance .
18781967	0	ICAM-1	31,37	LFA-1	25,30	ICAM-1	LFA-1	3383	3683	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Inhibitors targeting the LFA-1 / ICAM-1 cell-adhesion interaction : design and mechanism of action .
19184433	0	ICAM-1	60,66	LFA-1	12,17	ICAM-1	LFA-1	3383	3683	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Kinetics Kinetics|nmod|END_ENTITY	Kinetics of LFA-1 mediated adhesion of human neutrophils to ICAM-1 -- role of E-selectin signaling post-activation .
19307754	0	ICAM-1	0,6	LFA-1	7,12	ICAM-1	LFA-1	3383	3683	Gene	Gene	START_ENTITY|appos|contributes contributes|nsubj|interaction interaction|compound|END_ENTITY	ICAM-1 / LFA-1 interaction contributes to the induction of endothelial cell-cell separation : implication for enhanced leukocyte diapedesis .
1972160	0	ICAM-1	17,23	LFA-1	4,9	ICAM-1	LFA-1	3383	3689	Gene	Gene	provides|nsubj|START_ENTITY ligand|ccomp|provides ligand|nsubj|END_ENTITY	The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells .
1972656	0	ICAM-1	36,42	LFA-1	30,35	ICAM-1	LFA-1	3383	3683	Gene	Gene	system|compound|START_ENTITY involvement|dep|system involvement|nmod|END_ENTITY	Functional involvement of the LFA-1 / ICAM-1 adhesion system in the autologous mixed lymphocyte reaction .
20409465	0	ICAM-1	36,42	LFA-1	85,90	ICAM-1	LFA-1	3383	3689	Gene	Gene	bonds|compound|START_ENTITY states|nmod|bonds states|dep|lifetimes lifetimes|nmod|bonds bonds|compound|END_ENTITY	Long-lived , high-strength states of ICAM-1 bonds to beta2 integrin , II : lifetimes of LFA-1 bonds under force in leukocyte signaling .
20655213	0	ICAM-1	95,101	LFA-1	89,94	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Discovery of tetrahydroisoquinoline -LRB- THIQ -RRB- derivatives as potent and orally bioavailable LFA-1 / ICAM-1 antagonists .
21078912	0	ICAM-1	53,59	LFA-1	113,118	ICAM-1	LFA-1	3383	3683	Gene	Gene	LFA-1|nmod|START_ENTITY Occupancy|nmod|LFA-1 critical|nsubj|Occupancy critical|parataxis|not not|nmod|conversion conversion|compound|END_ENTITY	Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR - but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state .
21109434	0	ICAM-1	120,126	LFA-1	114,119	ICAM-1	LFA-1	3383	3683	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Structure-activity relationship -LRB- SAR -RRB- of the a-amino_acid residue of potent tetrahydroisoquinoline -LRB- THIQ -RRB- - derived LFA-1 / ICAM-1 antagonists .
21536861	0	ICAM-1	68,74	LFA-1	62,67	ICAM-1	LFA-1	3383	3683	Gene	Gene	bonds|compound|START_ENTITY stabilization|dep|bonds stabilization|nmod|END_ENTITY	Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1 : ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells .
24487103	0	ICAM-1	87,93	LFA-1	94,99	ICAM-1	LFA-1	3383	3683	Gene	Gene	peptides|nmod|START_ENTITY efficacy|nmod|peptides effect|nmod|efficacy effect|parataxis|studied studied|nsubj|END_ENTITY	The effect of acidic pH on the inhibitory efficacy of peptides against the interaction ICAM-1 / LFA-1 studied by surface plasmon resonance -LRB- SPR -RRB- .
2477252	1	ICAM-1	111,117	LFA-1	105,110	ICAM-1	LFA-1	3383	3683	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	The binding is elicited by both CD2/LFA -3 and LFA-1 / ICAM-1 interactions .
24900456	0	ICAM-1	42,48	LFA-1	36,41	ICAM-1	LFA-1	3383	3683	Gene	Gene	SAR_1118|compound|START_ENTITY Discovery|dep|SAR_1118 Discovery|nmod|END_ENTITY	Discovery and Development of Potent LFA-1 / ICAM-1 Antagonist SAR_1118 as an Ophthalmic Solution for Treating Dry_Eye .
24945611	0	ICAM-1	105,111	LFA-1	74,79	ICAM-1	LFA-1	3383	3683	Gene	Gene	nano-aggregates|compound|START_ENTITY restricts|nmod|nano-aggregates restricts|dobj|mobility mobility|nmod|END_ENTITY	Priming by chemokines restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nano-aggregates on human mature dendritic cells .
2497351	0	ICAM-1	77,83	LFA-1	57,62	ICAM-1	LFA-1	3383	3683	Gene	Gene	ligand|nmod|START_ENTITY ligand|nmod|END_ENTITY	Functional cloning of ICAM-2 , a cell adhesion ligand for LFA-1 homologous to ICAM-1 .
25032811	0	ICAM-1	172,178	LFA-1	125,130	ICAM-1	LFA-1	3383	3683	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY based|nmod|intercellular_adhesion_molecule-1 based|nmod|interactions interactions|nmod|leukocyte_function-associated_antigen-1 leukocyte_function-associated_antigen-1|appos|END_ENTITY	FRET based quantification and screening technology platform for the interactions of leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- with intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- .
25613092	0	ICAM-1	105,111	LFA-1	99,104	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Anti-OX40L monoclonal antibody prolongs secondary heart allograft survival based on CD40/CD40L and LFA-1 / ICAM-1 blockade .
26410859	0	ICAM-1	55,61	LFA-1	49,54	ICAM-1	LFA-1	3383	3683	Gene	Gene	interaction|compound|START_ENTITY stiffness|dep|interaction stiffness|nmod|cells cells|amod|END_ENTITY	Substrate stiffness of endothelial cells directs LFA-1 / ICAM-1 interaction : A physical trigger of immune-related diseases ?
3134364	0	ICAM-1	101,107	LFA-1	42,47	ICAM-1	LFA-1	3383	3683	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY interaction|nmod|intercellular_adhesion_molecule-1 interaction|appos|END_ENTITY	Lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- interaction with intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells .
3315233	0	ICAM-1	44,50	LFA-1	110,115	ICAM-1	LFA-1	3383	3683	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY ligand|nsubj|intercellular_adhesion_molecule-1 ligand|nmod|lymphocyte_function-associated_antigen_1 lymphocyte_function-associated_antigen_1|appos|END_ENTITY	Purified intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is a ligand for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
3525675	0	ICAM-1	41,47	LFA-1	63,68	ICAM-1	LFA-1	3383	3683	Gene	Gene	molecule|appos|START_ENTITY molecule|amod|distinct distinct|nmod|END_ENTITY	A human intercellular adhesion molecule -LRB- ICAM-1 -RRB- distinct from LFA-1 .
7518468	0	ICAM-1	71,77	LFA-1	33,38	ICAM-1	LFA-1	3383	3683	Gene	Gene	ligands|amod|START_ENTITY Involvement|nmod|ligands Involvement|nmod|domain domain|nmod|END_ENTITY	Involvement of the `` I '' domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3 .
7519104	0	ICAM-1	31,37	LFA-1	25,30	ICAM-1	LFA-1	3383	3683	Gene	Gene	pathways|compound|START_ENTITY aspects|dep|pathways aspects|nmod|END_ENTITY	Morphological aspects of LFA-1 / ICAM-1 and VLA4/VCAM -1 adhesion pathways in human lymph nodes .
7523142	0	ICAM-1	34,40	LFA-1	28,33	ICAM-1	LFA-1	3383	3689	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|compound|END_ENTITY	Adhesion molecules from the LFA-1 / ICAM-1 ,3 and VLA-4 / VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves ' and Hashimoto 's _ thyroid_glands .
7539005	0	ICAM-1	167,173	LFA-1	122,127	ICAM-1	LFA-1	3383	3683	Gene	Gene	Leukocyte_function-associated_antigen-1|appos|START_ENTITY Leukocyte_function-associated_antigen-1|amod|important important|nmod|binding binding|nmod|END_ENTITY	Identification of amino_acids in the CD11a I-domain important for binding of the leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- to intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- Leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- is a cell surface adhesion receptor for intercellular_adhesion_molecule-1 , -2 , and -3 -LRB- ICAM-1 , -2 , -3 -RRB- .
7586691	0	ICAM-1	168,174	LFA-1	222,227	ICAM-1	LFA-1	15894(Tax:10090)	16414(Tax:10090)	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Prevention of adoptive transfer of murine Sj gren 's syndrome into severe_combined_immunodeficient -LRB- SCID -RRB- mice by antibodies against intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- .
7641842	0	ICAM-1	36,42	LFA-1	55,60	ICAM-1	LFA-1	3383	3683	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	Monoclonal antibodies against CD54 -LRB- ICAM-1 -RRB- and CD11a -LRB- LFA-1 -RRB- prevent and inhibit endotoxin-induced uveitis .
7642561	0	ICAM-1	162,168	LFA-1	81,86	ICAM-1	LFA-1	3383	3683	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY required|nmod|intercellular_adhesion_molecule_1 END_ENTITY|acl|required	A binding interface on the I domain of lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- required for specific interaction with intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- .
7684326	2	ICAM-1	53,59	LFA-1	47,52	ICAM-1	LFA-1	3383	3683	Gene	Gene	molecules|compound|START_ENTITY Role|dep|molecules Role|nmod|END_ENTITY	Role of LFA-1 / ICAM-1 and CD2/LFA -3 adhesion molecules in CD3-induced proliferative response .
7707308	0	ICAM-1	57,63	LFA-1	51,56	ICAM-1	LFA-1	3383	3683	Gene	Gene	mediated|nsubj|START_ENTITY thiazole|parataxis|mediated thiazole|acl|based based|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel thiazole based heterocycles as inhibitors of LFA-1 / ICAM-1 mediated cell adhesion .
7821966	0	ICAM-1	0,6	LFA-1	7,12	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	START_ENTITY|dep|interactions interactions|compound|END_ENTITY	ICAM-1 / LFA-1 interactions in T-lymphocyte activation and adhesion to cells of the blood-retina barrier in the rat .
7844171	0	ICAM-1	120,126	LFA-1	0,5	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	redistribution|nmod|START_ENTITY redistribution|nsubj|integrin integrin|compound|END_ENTITY	LFA-1 integrin redistribution during T-cell hybridoma invasion of hepatocyte cultures and manganese-induced adhesion to ICAM-1 .
7852849	0	ICAM-1	19,25	LFA-1	13,18	ICAM-1	LFA-1	3383	3683	Gene	Gene	dependent|amod|START_ENTITY stimulation|amod|dependent lymphoid|nsubj|stimulation Evidence|parataxis|lymphoid Evidence|nmod|END_ENTITY	Evidence for LFA-1 / ICAM-1 dependent stimulation of protein tyrosine phosphorylation in human B lymphoid cell lines during homotypic adhesion .
7868060	0	ICAM-1	16,22	LFA-1	23,28	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	molecule|compound|START_ENTITY molecule|compound|END_ENTITY	-LSB- Involvement of ICAM-1 / LFA-1 adhesion molecule set in rat orthotopic liver transplantation -RSB- .
7879317	0	ICAM-1	43,49	LFA-1	97,102	ICAM-1	LFA-1	3383	3683	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- in peripheral blood mononuclear cell activation by human renal_carcinoma cells .
7901223	0	ICAM-1	52,58	LFA-1	46,51	ICAM-1	LFA-1	3383	3683	Gene	Gene	adhesion|compound|START_ENTITY adhesion|compound|END_ENTITY	ICAM-3 interacts with LFA-1 and regulates the LFA-1 / ICAM-1 cell adhesion pathway .
7903074	0	ICAM-1	14,20	LFA-1	8,13	ICAM-1	LFA-1	3383	3683	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of LFA-1 / ICAM-1 in interleukin-2-stimulated lymphocyte proliferation .
7908635	0	ICAM-1	26,32	LFA-1	33,38	ICAM-1	LFA-1	3383	3683	Gene	Gene	requirements|nmod|START_ENTITY requirements|dep|adhesion adhesion|compound|END_ENTITY	Different requirements of ICAM-1 / LFA-1 adhesion in allorecognition and self-restricted antigen recognition by class II-specific T cell clones .
7909511	0	ICAM-1	41,47	LFA-1	9,14	ICAM-1	LFA-1	3383	3683	Gene	Gene	site|compound|START_ENTITY contains|dobj|site contains|nsubj|END_ENTITY	Integrin LFA-1 alpha subunit contains an ICAM-1 binding site in domains V and VI .
7910490	0	ICAM-1	91,97	LFA-1	85,90	ICAM-1	LFA-1	3383	3683	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	TNF-induced microvascular pathology : active role for platelets and importance of the LFA-1 / ICAM-1 interaction .
7910869	0	ICAM-1	4,10	LFA-1	11,16	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|interaction interaction|nsubj|END_ENTITY	The ICAM-1 / LFA-1 interaction in glomerular leukocytic accumulation in anti-GBM glomerulonephritis .
7927492	0	ICAM-1	98,104	LFA-1	92,97	ICAM-1	LFA-1	3383	3689	Gene	Gene	function|dep|START_ENTITY function|dep|dependence dependence|nmod|END_ENTITY	Human hepatoma cells expressing MHC antigens display accessory cell function : dependence on LFA-1 / ICAM-1 interaction .
8094944	0	ICAM-1	17,23	LFA-1	11,16	ICAM-1	LFA-1	3383	3683	Gene	Gene	expression|compound|START_ENTITY expression|dep|Discordant Discordant|xcomp|END_ENTITY	Discordant LFA-1 / ICAM-1 expression in a case of secondary plasma_cell_leukemia associated with subcutaneous plasmacytoma .
8096435	0	ICAM-1	166,172	LFA-1	115,120	ICAM-1	LFA-1	3383	3683	Gene	Gene	lymphocyte_function-associated_antigen-1|appos|START_ENTITY lymphocyte_function-associated_antigen-1|appos|END_ENTITY	CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- and intercellular_cell_adhesion_molecule_1 -LRB- ICAM-1 -RRB- .
8526098	0	ICAM-1	102,108	LFA-1	96,101	ICAM-1	LFA-1	3383	3683	Gene	Gene	recognition|compound|START_ENTITY recognition|compound|END_ENTITY	T-lymphocyte proliferation stimulated by alpha beta TCR/CD2 bispecific antibody is dependent on LFA-1 / ICAM-1 recognition of accessory cells .
8982116	0	ICAM-1	83,89	LFA-1	77,82	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Substance_P promotes lymphocyte-endothelial cell adhesion preferentially via LFA-1 / ICAM-1 interactions .
9068010	0	ICAM-1	12,18	LFA-1	19,24	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|pathway pathway|compound|END_ENTITY	Role of the ICAM-1 / LFA-1 pathway during the development of autoimmune_dacryoadenitis in an animal model for Sj __ gren 's _ syndrome .
9129035	0	ICAM-1	83,89	LFA-1	77,82	ICAM-1	LFA-1	3383	3683	Gene	Gene	molecules|compound|START_ENTITY molecules|compound|END_ENTITY	Interleukin-4 induces homotypic aggregation of human mast cells by promoting LFA-1 / ICAM-1 adhesion molecules .
9283612	0	ICAM-1	0,6	LFA-1	7,12	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	ICAM-1 / LFA-1 expression in acute_osteodestructive_joint_lesions in collagen-induced arthritis in rats .
9337197	0	ICAM-1	125,131	LFA-1	132,137	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	blocking|dobj|START_ENTITY induced|advcl|blocking allograft|acl|induced Regulation|nmod|allograft END_ENTITY|dep|Regulation	Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1 / LFA-1 adhesion .
9381658	0	ICAM-1	24,30	LFA-1	18,23	ICAM-1	LFA-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	influences|nsubj|START_ENTITY END_ENTITY|parataxis|influences	Adhesion molecule LFA-1 / ICAM-1 influences on LPS-induced megakaryocytic emperipolesis in the rat bone marrow .
9452454	0	ICAM-1	46,52	LFA-1	25,30	ICAM-1	LFA-1	3383	3683	Gene	Gene	domain|compound|START_ENTITY interacts|nmod|domain interacts|nsubj|domain domain|nmod|END_ENTITY	The I domain of integrin LFA-1 interacts with ICAM-1 domain 1 at residue Glu-34 but not Gln-73 .
9499066	0	ICAM-1	141,147	LFA-1	29,34	ICAM-1	LFA-1	3383	3683	Gene	Gene	bearing|dobj|START_ENTITY particles|acl|bearing infection|nmod|particles susceptible|nmod|infection susceptible|nsubj|cells cells|acl|expressing expressing|dobj|END_ENTITY	T cells expressing activated LFA-1 are more susceptible to infection with human_immunodeficiency_virus_type_1 particles bearing host-encoded ICAM-1 .
9531273	0	ICAM-1	110,116	LFA-1	104,109	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Purified MHC class I and peptide complexes activate naive CD8 + T cells independently of the CD28/B7 and LFA-1 / ICAM-1 costimulatory interactions .
9574521	0	ICAM-1	47,53	LFA-1	30,35	ICAM-1	LFA-1	3383	3683	Gene	Gene	aggregation|amod|START_ENTITY binding|nmod|aggregation requirements|amod|binding requirements|nmod|END_ENTITY	Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation .
9587631	0	ICAM-1	35,41	LFA-1	85,90	ICAM-1	LFA-1	3383	3683	Gene	Gene	START_ENTITY|appos|leucocyte_function-associated_antigen-1 leucocyte_function-associated_antigen-1|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , leucocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- and leucocyte infiltration in proliferative human glomerulonephritis .
9671153	0	ICAM-1	85,91	LFA-1	32,37	ICAM-1	LFA-1	3383	3683	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|form form|nmod|END_ENTITY	Expression of a soluble form of LFA-1 and demonstration of its binding activity with ICAM-1 .
9820482	0	ICAM-1	23,29	LFA-1	0,5	ICAM-1	LFA-1	15894(Tax:10090)	16408(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production .
9951802	0	ICAM-1	122,128	LFA-1	129,134	ICAM-1	LFA-1	3383	3683	Gene	Gene	implication|nmod|START_ENTITY Atherosclerosis|nmod|implication Atherosclerosis|parataxis|END_ENTITY	Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1 / LFA-1 pathway in atherogenesis .
1375302	0	ICAM-1	47,53	LFA-3	65,70	ICAM-1	LFA-3	3383	965	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	Expression of surface adhesion molecules CD54 -LRB- ICAM-1 -RRB- and CD58 -LRB- LFA-3 -RRB- in adult acute_leukemia : relationship with initial characteristics and prognosis .
26276826	0	ICAM-1	16,22	Leptin	0,6	ICAM-1	Leptin	3383	3952	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Leptin Enhances ICAM-1 Expression , Induces Migration and Cytokine Synthesis , and Prolongs Survival of Human Airway Epithelial Cells .
2571505	0	ICAM-1	51,57	MALA-2	0,6	ICAM-1	MALA-2	3383	15894(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	MALA-2 , mouse homologue of human adhesion molecule ICAM-1 -LRB- CD54 -RRB- .
11311334	0	ICAM-1	91,97	MHC	48,51	ICAM-1	MHC	3383	3133	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive and cytokine-induced expression of MHC and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on human myoblasts .
22268119	0	ICAM-1	64,70	MK2	0,3	ICAM-1	MK2	3383	9261	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MK2 posttranscriptionally regulates TNF-a-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells .
12149643	0	ICAM-1	72,78	Matrix_metalloproteinase_9	0,26	ICAM-1	Matrix metalloproteinase 9	3383	4318	Gene	Gene	START_ENTITY|nsubj|cleaves cleaves|amod|END_ENTITY	Matrix_metalloproteinase_9 -LRB- MMP-9 / gelatinase B -RRB- proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity .
10362102	0	ICAM-1	25,31	NF-kappaB	103,112	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|nmod|line line|nmod|pathway pathway|amod|END_ENTITY	Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway .
10704144	0	ICAM-1	16,22	NF-kappaB	92,101	ICAM-1	NF-kappaB	15894(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Upregulation|nmod|expression involves|nsubj|Upregulation involves|dobj|activation activation|nmod|END_ENTITY	Upregulation of ICAM-1 expression on J774 .2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase : comparison to induction of iNOS .
10891363	0	ICAM-1	72,78	NF-kappaB	26,35	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene END_ENTITY|nmod|transcription	Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene .
12379212	0	ICAM-1	75,81	NF-kappaB	39,48	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|oligomer oligomer|nmod|END_ENTITY	A double-strand decoy DNA oligomer for NF-kappaB inhibits TNFalpha-induced ICAM-1 expression in sinusoidal endothelial cells .
17292586	0	ICAM-1	86,92	NF-kappaB	14,23	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	TNFR1-induced NF-kappaB , but not ERK , p38MAPK or JNK activation , mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells .
17334226	0	ICAM-1	71,77	NF-kappaB	123,132	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes .
18241674	0	ICAM-1	18,24	NF-kappaB	69,78	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nmod|activation activation|amod|END_ENTITY	Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells .
19351910	0	ICAM-1	134,140	NF-kappaB	0,9	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	site|nmod|START_ENTITY binding|nmod|site gene|amod|binding regulates|nmod|gene regulates|nsubj|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
19351910	0	ICAM-1	134,140	NF-kappaB	112,121	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
19351910	0	ICAM-1	37,43	NF-kappaB	0,9	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
19351910	0	ICAM-1	37,43	NF-kappaB	112,121	ICAM-1	NF-kappaB	3383	4790	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nmod|gene gene|amod|binding binding|nmod|site site|amod|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
20211170	0	ICAM-1	25,31	NF-kappaB	120,129	ICAM-1	NF-kappaB	15894(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|pathway pathway|compound|END_ENTITY	Hydrogen_sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway .
20823682	0	ICAM-1	167,173	NF-kappaB	117,126	ICAM-1	NF-kappaB	15894(Tax:10090)	18033(Tax:10090)	Gene	Gene	promoters|compound|START_ENTITY reducing|nmod|promoters reducing|dobj|recruitment recruitment|amod|END_ENTITY	Amelioration of dextran sulfate_sodium-induced chronic_colitis by sulfasalazine_salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters .
10666024	0	ICAM-1	32,38	NOS	99,102	ICAM-1	NOS	3383	4843	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Hyperbaric_oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia : the role of NOS .
20056088	0	ICAM-1	21,27	Nef	7,10	ICAM-1	Nef	3383	156110(Tax:11676)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- HIV-1 Nef regulates ICAM-1 expression on endothelial cells via Erk / Mapk signaling pathway -RSB- .
11463837	0	ICAM-1	50,56	Protein_kinase_C-delta	0,22	ICAM-1	Protein kinase C-delta	3383	5580	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Protein_kinase_C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38_mitogen-activated_protein_kinase .
11480498	0	ICAM-1	47,53	RANTES	167,173	ICAM-1	RANTES	3383	6352	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	The role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- , and regulated on activation , normal T-cell expressed and secreted -LRB- RANTES -RRB- in the relationship between air pollution and asthma among children .
23238746	0	ICAM-1	43,49	SIRT1	0,5	ICAM-1	SIRT1	3383	23411	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells .
22806433	0	ICAM-1	76,82	SLP-76	0,6	ICAM-1	SLP-76	3383	3937	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow .
15480988	0	ICAM-1	120,126	SP1	79,82	ICAM-1	SP1	3383	6667	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1 - and NF-kappaB-mediated induction of ICAM-1 .
11788788	0	ICAM-1	53,59	Sp1	116,119	ICAM-1	Sp1	15894(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|level level|acl|decreasing decreasing|dobj|END_ENTITY	Nitric_oxide inhibits endothelial IL-1 -LSB- beta -RSB- - induced ICAM-1 gene expression at the transcriptional level decreasing Sp1 and AP-1 activity .
21343678	0	ICAM-1	18,24	TGF-b1	40,46	ICAM-1	TGF-b1	3383	7040	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Radiation-induced ICAM-1 expression via TGF-b1 pathway on human umbilical vein endothelial cells ; comparison between X-ray and carbon-ion beam irradiation .
17357279	0	ICAM-1	25,31	TGF-beta1	0,9	ICAM-1	TGF-beta1	3383	7040	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	TGF-beta1 down-regulates ICAM-1 expression and enhances liver metastasis of pancreatic_cancer .
12823280	0	ICAM-1	17,23	THP-1	60,65	ICAM-1	THP-1	3383	2736	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|monocytes monocytes|compound|END_ENTITY	Up-regulation of ICAM-1 , CD11a/CD18 and CD11c/CD18 on human THP-1 monocytes stimulated by Streptococcus_suis serotype 2 .
9184693	0	ICAM-1	61,67	THP-1	108,113	ICAM-1	THP-1	3383	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Beta_2-integrin-mediated signal up-regulates counterreceptor ICAM-1 expression on human monocytic cell line THP-1 through tyrosine phosphorylation .
24875140	0	ICAM-1	43,49	TLR2/4	109,115	ICAM-1	TLR2/4	3383	7097;7099	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nmod|END_ENTITY	Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway .
21305449	0	ICAM-1	79,85	TNF-a	65,70	ICAM-1	TNF-a	3383	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Catechol , a bioactive degradation product of salicortin , reduces TNF-a induced ICAM-1 expression in human endothelial cells .
21507295	0	ICAM-1	21,27	TNF-a	12,17	ICAM-1	TNF-a	3383	7124	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of TNF-a on ICAM-1 and LFA-1 expression in peripheral blood mononuclear cells of children with febrile_seizures -RSB- .
22190402	0	ICAM-1	99,105	TNF-a	71,76	ICAM-1	TNF-a	3383	7124	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Arylalkyl_ketones , benzophenones , desoxybenzoins and chalcones inhibit TNF-a induced expression of ICAM-1 : structure-activity analysis .
23042271	0	ICAM-1	56,62	TNF-a	101,106	ICAM-1	TNF-a	3383	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Protein C activation peptide inhibits the expression of ICAM-1 , VCAM-1 , and interleukin-8 induced by TNF-a in human dermal microvascular endothelial cells .
23548604	0	ICAM-1	9,15	TNF-a	112,117	ICAM-1	TNF-a	3383	7124	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Increase ICAM-1 and LFA-1 expression by cerebrospinal fluid of subarachnoid_hemorrhage patients : involvement of TNF-a .
25026345	0	ICAM-1	121,127	TNF-a	57,62	ICAM-1	TNF-a	3383	7124	Gene	Gene	expression|appos|START_ENTITY tumor_necrosis_factor-a|dep|expression tumor_necrosis_factor-a|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
25675437	0	ICAM-1	66,72	TNF-a	0,5	ICAM-1	TNF-a	3383	7124	Gene	Gene	Induction|compound|START_ENTITY Adhesion|nmod|Induction JNK1/2/c-Jun-Dependent|dobj|Adhesion PKC|parataxis|JNK1/2/c-Jun-Dependent PKC|compound|END_ENTITY	TNF-a Mediates PKC / JNK1/2/c-Jun-Dependent Monocyte Adhesion via ICAM-1 Induction in Human Retinal Pigment Epithelial Cells .
26413796	0	ICAM-1	92,98	TNF-a	54,59	ICAM-1	TNF-a	3383	7124	Gene	Gene	phosphorylation|compound|START_ENTITY expression|nmod|phosphorylation expression|amod|END_ENTITY	Ultraviolet light-emitting-diode irradiation inhibits TNF-a and IFN-y-induced expression of ICAM-1 and STAT1 phosphorylation in human keratinocytes .
10491002	0	ICAM-1	51,57	TNF-alpha	0,9	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	TNF-alpha and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice .
10837365	0	ICAM-1	38,44	TNF-alpha	11,20	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro .
11247755	0	ICAM-1	23,29	TNF-alpha	90,99	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	disruption|nmod|START_ENTITY Targeted|dobj|disruption improves|advcl|Targeted improves|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Targeted disruption of ICAM-1 , P-selectin genes improves cardiac function and survival in TNF-alpha transgenic_mice .
11817671	0	ICAM-1	8,14	TNF-alpha	92,101	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	Role|nmod|START_ENTITY macrophages|nsubj|Role macrophages|nmod|END_ENTITY	Role of ICAM-1 in the aggregation and adhesion of human alveolar macrophages in response to TNF-alpha and INF-gamma .
11888521	0	ICAM-1	32,38	TNF-alpha	14,23	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression induced|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of TNF-alpha induced ICAM-1 , VCAM-1 and E-selectin expression by selenium .
1357985	0	ICAM-1	13,19	TNF-alpha	23,32	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of ICAM-1 by TNF-alpha , IL-1_beta , and LPS in human endothelial cells after downregulation of PKC .
15342194	0	ICAM-1	0,6	TNF-alpha	117,126	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	upregulation|compound|START_ENTITY dependent|nsubj|upregulation dependent|nmod|production production|amod|END_ENTITY	ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity .
15656142	0	ICAM-1	53,59	TNF-alpha	42,51	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of shuangshen tongguan -LRB- SSTG -RRB- on TNF-alpha , ICAM-1 during myocardial_ischemia-reperfusion injury -RSB- .
15698778	0	ICAM-1	55,61	TNF-alpha	37,46	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|compound|START_ENTITY induced|dobj|expression induced|nsubj|thiocoumarins thiocoumarins|nmod|inhibitors inhibitors|nmod|END_ENTITY	Novel thiocoumarins as inhibitors of TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells -LRB- HUVECs -RRB- and microsomal lipid peroxidation .
16431966	0	ICAM-1	75,81	TNF-alpha	29,38	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Glucosamine_sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitro .
16766643	0	ICAM-1	81,87	TNF-alpha	0,9	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY alters|dobj|distribution alters|nsubj|activation activation|amod|END_ENTITY	TNF-alpha activation of arterioles and venules alters distribution and levels of ICAM-1 and affects leukocyte-endothelial cell interactions .
17607964	0	ICAM-1	77,83	TNF-alpha	258,267	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY -LSB-|nmod|intercellular_adhesion_molecule-1 induced|csubj|-LSB- induced|nmod|-RSB- -RSB-|appos|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
17683945	0	ICAM-1	125,131	TNF-alpha	98,107	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	The interaction between myocardial depressant factors in endotoxemic_cardiac_dysfunction : role of TNF-alpha in TLR4-mediated ICAM-1 expression .
18475479	0	ICAM-1	17,23	TNF-alpha	99,108	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	correlate|nsubj|START_ENTITY correlate|nmod|END_ENTITY	Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-alpha and blood-brain barrier damage .
18989464	0	ICAM-1	13,19	TNF-alpha	79,88	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY lingual|nsubj|Induction lingual|nmod|END_ENTITY	Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-alpha .
19203796	0	ICAM-1	105,111	TNF-alpha	57,66	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	associated|nmod|START_ENTITY cytotoxicity|acl|associated uncouple|nmod|cytotoxicity uncouple|dobj|expression expression|nmod|END_ENTITY	Lipid rafts uncouple surface expression of transmembrane TNF-alpha from its cytotoxicity associated with ICAM-1 clustering in Raji cells .
19338980	0	ICAM-1	64,70	TNF-alpha	74,83	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	induction|nmod|START_ENTITY gene|nmod|induction Role|nmod|gene Role|nmod|END_ENTITY	Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha .
19674910	0	ICAM-1	97,103	TNF-alpha	65,74	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|nmod|START_ENTITY induced|dobj|expression effect|acl|induced effect|nmod|END_ENTITY	Inhibitory effect of beta-diketones and their metal complexes on TNF-alpha induced expression of ICAM-1 on human endothelial cells .
19716548	0	ICAM-1	189,195	TNF-alpha	49,58	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	TNF_receptor|appos|START_ENTITY role|nmod|TNF_receptor suggests|dobj|role suggests|nsubj|Activation Activation|nmod|pathway pathway|nmod|END_ENTITY	Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland -LRB- HSG -RRB- cells in vitro , suggests a role for the TNF_receptor -LRB- TNF-R -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in Sj gren 's syndrome-associated autoimmune_sialadenitis .
22574597	0	ICAM-1	163,169	TNF-alpha	152,161	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of yiqi huoxue compound contained drug serum on the expressions of toll-like_receptor_4 and downstream signal transduction pathway , and LOX-1 , TNF-alpha , ICAM-1 in the human vein endothelial cells -RSB- .
24710469	0	ICAM-1	174,180	TNF-alpha	87,96	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|amod|START_ENTITY suppressing|dobj|expression cells|acl|suppressing adhesion|dep|cells adhesion|nmod|END_ENTITY	Rabbit sera containing compound danshen dripping pill attenuate leukocytes adhesion to TNF-alpha -- activated human umbilical vein endothelial cells by suppressing endothelial ICAM-1 and VCAM-1 expression through NF-kappaB signaling pathway .
7729535	0	ICAM-1	17,23	TNF-alpha	94,103	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|compound|START_ENTITY Up-regulation|nmod|expression fibroblasts|nsubj|Up-regulation fibroblasts|nmod|presence presence|nmod|END_ENTITY	Up-regulation of ICAM-1 expression on human dermal fibroblasts by IFN-beta in the presence of TNF-alpha .
7957928	0	ICAM-1	61,67	TNF-alpha	72,81	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|nmod|END_ENTITY	Synergistic activation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- by TNF-alpha and IFN-gamma is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1 alpha -LRB- p91 -RRB- that can be activated by both IFN-gamma and IFN-alpha .
8530159	0	ICAM-1	35,41	TNF-alpha	75,84	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	Intercellular_adhesion_molecule_1|appos|START_ENTITY activated|nsubjpass|Intercellular_adhesion_molecule_1 activated|nmod|sites sites|compound|END_ENTITY	Intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- is synergistically activated by TNF-alpha and IFN-gamma responsive sites .
8973625	0	ICAM-1	104,110	TNF-alpha	190,199	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	intercellular_adhesion_molecule-1|dep|START_ENTITY factor-alpha|amod|intercellular_adhesion_molecule-1 factor-alpha|appos|END_ENTITY	Expression of leucocyte-endothelial adhesion molecules is limited to intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the lung of pneumoconiotic patients : role of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- .
9035283	0	ICAM-1	118,124	TNF-alpha	89,98	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	Inhibition of NF-kappa_B activation by dimethyl_sulfoxide correlates with suppression of TNF-alpha formation , reduced ICAM-1 gene transcription , and protection against endotoxin-induced liver_injury .
9105426	0	ICAM-1	76,82	TNF-alpha	35,44	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|nmod|START_ENTITY induced|dobj|expression induced|nsubj|Role Role|nmod|enzymes enzymes|nmod|END_ENTITY	Role of tyrosine kinase enzymes in TNF-alpha and IL-1 induced expression of ICAM-1 and VCAM-1 on human umbilical vein endothelial cells .
9274840	0	ICAM-1	11,17	TNF-alpha	52,61	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|nsubj|START_ENTITY expression|xcomp|related related|advcl|circulating circulating|dobj|END_ENTITY	Glomerular ICAM-1 expression related to circulating TNF-alpha in human glomerulonephritis .
9378369	0	ICAM-1	28,34	TNF-alpha	59,68	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY increases|nmod|mRNA independent|nsubj|increases independent|nmod|END_ENTITY	Hyperoxic increases in lung ICAM-1 mRNA are independent of TNF-alpha and IL-1_beta mRNA .
9521860	0	ICAM-1	57,63	TNF-alpha	0,9	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNF-alpha and 9-cis-retinoic_acid synergistically induce ICAM-1 expression : evidence for interaction of retinoid receptors with NF-kappa_B .
9607608	0	ICAM-1	0,6	TNF-alpha	40,49	ICAM-1	TNF-alpha	3383	7124	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic .
9973425	0	ICAM-1	40,46	TNF-alpha	150,159	ICAM-1	TNF-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice : evidence for a dominant role of TNF-alpha .
14572618	0	ICAM-1	37,43	TNFalpha	11,19	ICAM-1	TNFalpha	3383	7124	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro : oxidant-mediated pathways and transcription factors .
15480988	0	ICAM-1	120,126	TNFalpha	0,8	ICAM-1	TNFalpha	3383	7124	Gene	Gene	induction|nmod|START_ENTITY contractility|nmod|induction suppresses|dobj|contractility suppresses|nsubj|END_ENTITY	TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1 - and NF-kappaB-mediated induction of ICAM-1 .
15864742	0	ICAM-1	0,6	TNFalpha	20,28	ICAM-1	TNFalpha	3383	7124	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	ICAM-1 induction by TNFalpha and IL-6 is mediated by distinct pathways via Rac in endothelial cells .
24506791	0	ICAM-1	17,23	Thrombin	0,8	ICAM-1	Thrombin	3383	2147	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces ICAM-1 expression in human lung epithelial cells via c-Src/PDGFR/PI3K / Akt-dependent NF-kB/p300 activation .
24685520	0	ICAM-1	69,75	Transforming_growth_factor_alpha	0,32	ICAM-1	Transforming growth factor alpha	3383	7124	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Transforming_growth_factor_alpha promotes osteosarcoma_metastasis by ICAM-1 and PI3K/Akt signaling pathway .
26177712	0	ICAM-1	41,47	Tumor_Necrosis_Factor-Alpha	0,27	ICAM-1	Tumor Necrosis Factor-Alpha	3383	7124	Gene	Gene	START_ENTITY|nsubj|Up-Regulates Up-Regulates|compound|END_ENTITY	Tumor_Necrosis_Factor-Alpha Up-Regulates ICAM-1 Expression and Release in Intestinal Myofibroblasts by Redox-Dependent and - Independent Mechanisms .
12111363	0	ICAM-1	62,68	Tumor_necrosis_factor-alpha	0,27	ICAM-1	Tumor necrosis factor-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF -RRB- regulates the expression of ICAM-1 predominantly through TNF receptor 1 after chronic constriction_injury_of_mouse_sciatic_nerve .
8095156	0	ICAM-1	39,45	Tumor_necrosis_factor-alpha	0,27	ICAM-1	Tumor necrosis factor-alpha	3383	7124	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha stimulates ICAM-1 expression in human vascular smooth muscle cells .
8906209	0	ICAM-1	48,54	Tumor_necrosis_factor_alpha	0,27	ICAM-1	Tumor necrosis factor alpha	3383	7124	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- - induced ICAM-1 surface expression in airway epithelial cells in vitro : possible signal transduction mechanisms .
10050668	0	ICAM-1	93,99	VCAM-1	110,116	ICAM-1	VCAM-1	15894(Tax:10090)	22329(Tax:10090)	Gene	Gene	Mac-1|dep|START_ENTITY modulation|nmod|Mac-1 eotaxin|nmod|modulation interactions|amod|eotaxin interactions|compound|END_ENTITY	Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1 / ICAM-1 and VLA-4 / VCAM-1 interactions .
10072550	0	ICAM-1	12,18	VCAM-1	63,69	ICAM-1	VCAM-1	3383	7412	Gene	Gene	Ligation|nmod|START_ENTITY leads|nsubj|Ligation leads|nmod|expression expression|nmod|END_ENTITY	Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism .
11348999	0	ICAM-1	154,160	VCAM-1	162,168	ICAM-1	VCAM-1	3383	7412	Gene	Gene	CD34|compound|START_ENTITY CD34|dep|END_ENTITY	Infection of endothelium with E1 -LRB- - -RRB- E4 -LRB- + -RRB- , but not E1 -LRB- - -RRB- E4 -LRB- - -RRB- , adenovirus gene transfer vectors enhances leukocyte adhesion and migration by modulation of ICAM-1 , VCAM-1 , CD34 , and chemokine expression .
11356255	0	ICAM-1	56,62	VCAM-1	103,109	ICAM-1	VCAM-1	281839(Tax:9913)	282118(Tax:9913)	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Regulation of bovine intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- on cultured aortic endothelial cells .
11375415	0	ICAM-1	33,39	VCAM-1	17,23	ICAM-1	VCAM-1	15894(Tax:10090)	22329(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A major role for VCAM-1 , but not ICAM-1 , in early atherosclerosis .
11376630	0	ICAM-1	25,31	VCAM-1	99,105	ICAM-1	VCAM-1	3383	7412	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|induction induction|nmod|END_ENTITY	Effects of cross-linking ICAM-1 on the surface of human vascular smooth muscle cells : induction of VCAM-1 but no proliferation .
11480498	0	ICAM-1	47,53	VCAM-1	91,97	ICAM-1	VCAM-1	3383	7412	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|amod|vascular_cell_adhesion_molecule-1 vascular_cell_adhesion_molecule-1|dep|END_ENTITY	The role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- , and regulated on activation , normal T-cell expressed and secreted -LRB- RANTES -RRB- in the relationship between air pollution and asthma among children .
11493610	0	ICAM-1	42,48	VCAM-1	49,55	ICAM-1	VCAM-1	15894(Tax:10090)	22329(Tax:10090)	Gene	Gene	up-regulation|dep|START_ENTITY up-regulation|compound|END_ENTITY	IL-1_and_TNF independent pathways mediate ICAM-1 / VCAM-1 up-regulation in ischemia reperfusion injury .
11857637	0	ICAM-1	20,26	VCAM-1	37,43	ICAM-1	VCAM-1	3383	7412	Gene	Gene	LFA-1|dep|START_ENTITY Inhibition|nmod|LFA-1 END_ENTITY|nsubj|Inhibition	Inhibition of LFA-1 / ICAM-1 and VLA-4 / VCAM-1 as a therapeutic approach to inflammation and autoimmune_diseases .
14603993	0	ICAM-1	12,18	VCAM-1	20,26	ICAM-1	VCAM-1	3383	7412	Gene	Gene	P-selectin|compound|START_ENTITY P-selectin|appos|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFalphaRII in patients with coronary_artery_disease .
15495786	0	ICAM-1	12,18	VCAM-1	20,26	ICAM-1	VCAM-1	3383	7412	Gene	Gene	P-selectin|compound|START_ENTITY P-selectin|appos|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFRII in patients with coronary_artery_disease .
16303942	0	ICAM-1	40,46	VCAM-1	47,53	ICAM-1	VCAM-1	3383	7412	Gene	Gene	upregulation|nmod|START_ENTITY implications|nmod|upregulation implications|dep|expression expression|compound|END_ENTITY	The implications of the upregulation of ICAM-1 / VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic_keratopathy .
16425378	0	ICAM-1	27,33	VCAM-1	35,41	ICAM-1	VCAM-1	3383	7412	Gene	Gene	P-selectin|amod|START_ENTITY P-selectin|amod|END_ENTITY	Soluble adhesion molecules ICAM-1 , VCAM-1 , P-selectin in children with Helicobacter_pylori_infection .
16834788	0	ICAM-1	82,88	VCAM-1	129,135	ICAM-1	VCAM-1	3383	7412	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	The influence of propofol on the expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in reoxygenated human umbilical vein endothelial cells .
16981649	0	ICAM-1	131,137	VCAM-1	123,129	ICAM-1	VCAM-1	3383	7412	Gene	Gene	selectins|dep|START_ENTITY selectins|appos|END_ENTITY	Application of Evidence Investigator for the simultaneous measurement of soluble adhesion molecules : L - , _ P - , _ E - _ selectins , VCAM-1 , ICAM-1 in a biochip platform .
20300427	0	ICAM-1	0,6	VCAM-1	48,54	ICAM-1	VCAM-1	3383	7412	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|END_ENTITY	ICAM-1 clustering on endothelial cells recruits VCAM-1 .
21860594	0	ICAM-1	60,66	VCAM-1	45,51	ICAM-1	VCAM-1	3383	7412	Gene	Gene	Expression|compound|START_ENTITY Not|nmod|Expression Inhibits|dep|Not Inhibits|dobj|END_ENTITY	Genipin Selectively Inhibits TNF-a-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-y in Human Endothelial Cells .
7517695	0	ICAM-1	49,55	VCAM-1	96,102	ICAM-1	VCAM-1	3383	7412	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- on proliferating vascular endothelial cells in diabetic_epiretinal_membranes .
7686390	0	ICAM-1	47,53	VCAM-1	106,112	ICAM-1	VCAM-1	3383	7412	Gene	Gene	adhesion|dep|START_ENTITY adhesion|appos|END_ENTITY	Circulating intercellular adhesion molecule-1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in human malignancies .
9180243	0	ICAM-1	123,129	VCAM-1	178,184	ICAM-1	VCAM-1	3383	7412	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	New indices of ischemic_heart_disease and aging : studies on the serum levels of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and soluble vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in patients with hypercholesterolemia and ischemic_heart_disease .
9529982	0	ICAM-1	68,74	VCAM-1	115,121	ICAM-1	VCAM-1	3383	7412	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Synchronous elevation of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- correlates with gastric_cancer progression .
9694714	0	ICAM-1	137,143	VCAM-1	190,196	ICAM-1	VCAM-1	3383	7412	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 ; CD54 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 ; CD106 -RRB- .
9888481	0	ICAM-1	47,53	VCAM-1	106,112	ICAM-1	VCAM-1	3383	7412	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Circulating intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in head_and_neck_cancer .
10393052	0	ICAM-1	32,38	VEGF	0,4	ICAM-1	VEGF	3383	7422	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	VEGF increases retinal vascular ICAM-1 expression in vivo .
10793084	0	ICAM-1	130,136	VEGF	36,40	ICAM-1	VEGF	25464(Tax:10116)	83785(Tax:10116)	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY mediated|nmod|intercellular_adhesion_molecule-1 permeability|acl:relcl|mediated Vascular_endothelial_growth_factor|dep|permeability Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced retinal_vascular permeability is mediated by intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- .
24940033	0	ICAM-1	14,20	VEGF	111,115	ICAM-1	VEGF	3383	7422	Gene	Gene	expression|compound|START_ENTITY mediated|nsubjpass|expression mediated|nmod|stimulation stimulation|amod|END_ENTITY	TNF-a-induced ICAM-1 expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation .
10787417	0	ICAM-1	48,54	Vascular_endothelial_growth_factor	0,34	ICAM-1	Vascular endothelial growth factor	25464(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric _ oxide pathway and modulates migration of brain microvascular endothelial cells .
10793084	0	ICAM-1	130,136	Vascular_endothelial_growth_factor	0,34	ICAM-1	Vascular endothelial growth factor	25464(Tax:10116)	83785(Tax:10116)	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY mediated|nmod|intercellular_adhesion_molecule-1 permeability|acl:relcl|mediated END_ENTITY|dep|permeability	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced retinal_vascular permeability is mediated by intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- .
11108718	0	ICAM-1	84,90	Vascular_endothelial_growth_factor	0,34	ICAM-1	Vascular endothelial growth factor	3383	7422	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY expression|nmod|intercellular_adhesion_molecule_1 expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- , and E-selectin through nuclear factor-kappa B activation in endothelial cells .
18241674	0	ICAM-1	18,24	Visfatin	0,8	ICAM-1	Visfatin	3383	10135	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells .
25454492	0	ICAM-1	56,62	Wnt-5a	23,29	ICAM-1	Wnt-5a	3383	7474	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Human placenta-derived Wnt-5a induces the expression of ICAM-1 and VCAM-1 in CD133 -LRB- + -RRB- CD34 -LRB- + -RRB- - hematopoietic progenitor cells .
10342582	0	ICAM-1	50,56	beta-2_microglobulin	58,78	ICAM-1	beta-2 microglobulin	3383	567	Gene	Gene	value|nmod|START_ENTITY value|appos|levels levels|amod|END_ENTITY	Correlation and prognostic value of serum soluble ICAM-1 , beta-2_microglobulin , and IL-2alphaR levels in non-Hodgkin 's _ lymphoma .
11552664	0	ICAM-1	102,108	beta-2_microglobulin	34,54	ICAM-1	beta-2 microglobulin	3383	567	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|amod|END_ENTITY	Effect of cladribine treatment on beta-2_microglobulin and soluble intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in patients with multiple_sclerosis .
24875140	0	ICAM-1	43,49	biglycan	8,16	ICAM-1	biglycan	3383	633	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway .
21680714	0	ICAM-1	15,21	c-Met	0,5	ICAM-1	c-Met	15894(Tax:10090)	17295(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice .
8706128	0	ICAM-1	41,47	cytohesin-1	59,70	ICAM-1	cytohesin-1	3383	9267	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Alpha L beta 2 integrin/LFA -1 binding to ICAM-1 induced by cytohesin-1 , a cytoplasmic regulatory molecule .
11099110	0	ICAM-1	49,55	intercellular_adhesio_nmolecule-1	14,47	ICAM-1	intercellular adhesio nmolecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of intercellular_adhesio_nmolecule-1 -LRB- ICAM-1 -RRB- expression in ultraviolet B-irradiated human antigen-presenting_cells is restored after repair of cyclobutane_pyrimidine_dimers .
10076954	0	ICAM-1	84,90	intercellular_adhesion_molecule	51,82	ICAM-1	intercellular adhesion molecule	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hemorrhagic_shock results in intestinal muscularis intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- expression , neutrophil infiltration , and smooth muscle_dysfunction .
12545819	0	ICAM-1	62,68	intercellular_adhesion_molecule	29,60	ICAM-1	intercellular adhesion molecule	3383	3383	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	-LSB- Transcription regulation of intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- on lymphatic endothelial cells of rectum adenocarcinoma of human -RSB- .
2469503	0	ICAM-1	69,75	intercellular_adhesion_molecule	36,67	ICAM-1	intercellular adhesion molecule	3383	3383	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of expression of a human intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- during lymphohematopoietic differentiation .
8838428	0	ICAM-1	69,75	intercellular_adhesion_molecule	36,67	ICAM-1	intercellular adhesion molecule	3383	3383	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of the intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- on the cell surface of high endothelial venules in lymph nodes .
9990314	0	ICAM-1	106,112	intercellular_adhesion_molecule	73,104	ICAM-1	intercellular adhesion molecule	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two gamma-interferon-activation sites -LRB- GAS -RRB- on the promoter of the human intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- gene are required for induction of transcription by IFN-gamma .
10030601	0	ICAM-1	56,62	intercellular_adhesion_molecule-1	21,54	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	In vitro and in situ intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by endothelial cells lining a polyester fabric .
10435852	0	ICAM-1	65,71	intercellular_adhesion_molecule-1	30,63	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Longitudinal study of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in sera of patients with Graves ' _ disease .
10490211	0	ICAM-1	57,63	intercellular_adhesion_molecule-1	22,55	ICAM-1	intercellular adhesion molecule-1	281839(Tax:9913)	281839(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	In situ expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- mRNA in calves with acute Pasteurella_haemolytica pneumonia .
10517737	0	ICAM-1	61,67	intercellular_adhesion_molecule-1	26,59	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II stimulates intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo .
10692259	0	ICAM-1	58,64	intercellular_adhesion_molecule-1	23,56	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in amnion with term and preterm_labour .
10752199	0	ICAM-1	44,50	intercellular_adhesion_molecule-1	9,42	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	-LSB- Soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- levels in HIV infected children -RSB- .
10773353	0	ICAM-1	88,94	intercellular_adhesion_molecule-1	53,86	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between type 1 diabetes age-at-onset and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphism .
10971511	0	ICAM-1	86,92	intercellular_adhesion_molecule-1	51,84	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Triamcinolone_acetonide modulates permeability and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression of the ECV304 cell line : implications for macular_degeneration .
11122238	0	ICAM-1	161,167	intercellular_adhesion_molecule-1	126,159	ICAM-1	intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Roles of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , transforming growth factor-beta -LRB- TGF-beta -RRB- , and IL-10 in the modulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by macrophages during mycobacterial_infection .
11151765	0	ICAM-1	56,62	intercellular_adhesion_molecule-1	21,54	ICAM-1	intercellular adhesion molecule-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	High glucose-induced intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent .
12185712	0	ICAM-1	50,56	intercellular_adhesion_molecule-1	15,48	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on the surface of peripheral blood lymphocytes of pregnant women with pregnancy-induced hypertension -RSB- .
12551926	0	ICAM-1	110,116	intercellular_adhesion_molecule-1	75,108	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Human rhinovirus selectively modulates membranous and soluble forms of its intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- receptor to promote epithelial cell infectivity .
1281230	0	ICAM-1	95,101	intercellular_adhesion_molecule-1	60,93	ICAM-1	intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Endothelial_cell_leukocyte_adhesion_molecule-1 -LRB- ELAM-1 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in gingival tissue during health and experimentally-induced gingivitis .
1349161	0	ICAM-1	53,59	intercellular_adhesion_molecule-1	18,51	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in human renal allografts and cultured human tubular cells .
1352310	0	ICAM-1	51,57	intercellular_adhesion_molecule-1	16,49	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide .
1352747	0	ICAM-1	47,53	intercellular_adhesion_molecule-1	12,45	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Circulating intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- antigen in sera of patients with idiopathic_pulmonary_fibrosis .
1355095	0	ICAM-1	50,56	intercellular_adhesion_molecule-1	15,48	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- with actin-containing cytoskeleton and alpha-actinin .
1356028	0	ICAM-1	57,63	intercellular_adhesion_molecule-1	22,55	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Possible induction of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on endothelial cells by platelet-activating_factor -LRB- PAF -RRB- .
1373746	0	ICAM-1	120,126	intercellular_adhesion_molecule-1	85,118	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The state of differentiation of cultured human keratinocytes determines the level of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression induced by gamma interferon .
15142692	0	ICAM-1	72,78	intercellular_adhesion_molecule-1	37,70	ICAM-1	intercellular adhesion molecule-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Thrombosis and altered expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- after avulsion_injury in rat vessels .
15866119	0	ICAM-1	74,80	intercellular_adhesion_molecule-1	39,72	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of endometriosis and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphisms in a Japanese population .
1673709	0	ICAM-1	66,72	intercellular_adhesion_molecule-1	31,64	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cytokine-induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in cultured human oligodendrocytes and astrocytes .
1676215	0	ICAM-1	49,55	intercellular_adhesion_molecule-1	14,47	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in benign naevi and malignant_melanomas .
1680698	0	ICAM-1	78,84	intercellular_adhesion_molecule-1	43,76	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression , function and regulation of the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on human intestinal epithelial cell lines .
1682392	0	ICAM-1	49,55	intercellular_adhesion_molecule-1	14,47	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the skin of patients with systemic_scleroderma .
16938116	0	ICAM-1	98,104	intercellular_adhesion_molecule-1	63,96	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Synergistic effect of interleukin-6 promoter -LRB- IL6 -634 C/G -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 469K/E -RRB- gene polymorphisms on the risk of endometriosis in Japanese women .
19074768	0	ICAM-1	172,178	intercellular_adhesion_molecule-1	137,170	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Protein_kinase_C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian_target_of_rapamycin to modulate NF-kappaB activation and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in endothelial cells .
1973679	0	ICAM-1	57,63	intercellular_adhesion_molecule-1	22,55	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Hepatic expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in viral hepatitis_B .
1974176	0	ICAM-1	58,64	intercellular_adhesion_molecule-1	23,56	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cytokine regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on human glioblastoma cells .
1977768	0	ICAM-1	70,76	intercellular_adhesion_molecule-1	35,68	ICAM-1	intercellular adhesion molecule-1	100717967	100717967	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Endothelial cell expression of the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the central nervous system of guinea_pigs during acute and chronic relapsing experimental_allergic_encephalomyelitis .
20665551	0	ICAM-1	124,130	intercellular_adhesion_molecule-1	89,122	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-17 synergizes with IFNy or TNFa to promote inflammatory mediator release and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human intervertebral disc cells .
22609477	0	ICAM-1	39,45	intercellular_adhesion_molecule-1	4,37	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	The intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphism K469E in end-stage_renal_disease patients with cardiovascular_disease .
25026345	0	ICAM-1	121,127	intercellular_adhesion_molecule-1	86,119	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
2654218	0	ICAM-1	68,74	intercellular_adhesion_molecule-1	33,66	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Kinetics and characterization of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on keratinocytes in various inflammatory skin_lesions and malignant cutaneous_lymphomas .
3257922	0	ICAM-1	57,63	intercellular_adhesion_molecule-1	22,55	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	The function of human intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the generation of an immune response .
7507012	0	ICAM-1	65,71	intercellular_adhesion_molecule-1	30,63	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MHC class I , MHC class II and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in inflammatory_myopathies .
7705360	0	ICAM-1	68,74	intercellular_adhesion_molecule-1	33,66	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive expression of human intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is regulated by differentially active enhancing and silencing elements .
7798616	0	ICAM-1	73,79	intercellular_adhesion_molecule-1	38,71	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Suppressive effect of antioxidants on intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human epidermal keratinocytes .
7880394	0	ICAM-1	49,55	intercellular_adhesion_molecule-1	14,47	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on cultured human endometrial stromal cells and its role in the interaction with natural killers .
7901895	0	ICAM-1	43,49	intercellular_adhesion_molecule-1	8,41	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- antigen in patients with rheumatoid_arthritis .
7909596	0	ICAM-1	49,55	intercellular_adhesion_molecule-1	14,47	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by reactive mesothelial cells in pleural_effusions .
7930472	0	ICAM-1	93,99	intercellular_adhesion_molecule-1	58,91	ICAM-1	intercellular adhesion molecule-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Cultured rat hepatic sinusoidal endothelial cells express intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by tumor_necrosis_factor-alpha or interleukin-1_alpha stimulation .
7974918	0	ICAM-1	50,56	intercellular_adhesion_molecule-1	15,48	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Stimulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- antigen expression and shedding by interferon-gamma and phorbol_ester in human renal_carcinoma cell cultures : relation to peripheral blood mononuclear cell adhesion .
8104198	0	ICAM-1	49,55	intercellular_adhesion_molecule-1	14,47	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in ischemic and reperfused canine myocardium .
8105425	0	ICAM-1	67,73	intercellular_adhesion_molecule-1	32,65	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum and CSF levels of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in inflammatory neurologic_diseases .
9057191	0	ICAM-1	53,59	intercellular_adhesion_molecule-1	18,51	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in pancreatic_adenocarcinoma in comparison with normal pancreas .
9158091	0	ICAM-1	91,97	intercellular_adhesion_molecule-1	56,89	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of the endothelial cell adhesion molecule intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by autoantibodies in autoimmune_vasculitis .
9215589	0	ICAM-1	49,55	intercellular_adhesion_molecule-1	14,47	ICAM-1	intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction as an experimental disseminated intravascular_coagulation model .
9269313	0	ICAM-1	72,78	intercellular_adhesion_molecule-1	37,70	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Late and persistent up-regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by ionizing radiation in human endothelial cells in vitro .
9353323	0	ICAM-1	85,91	intercellular_adhesion_molecule-1	50,83	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Targeted inhibition of interferon-gamma-dependent intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression using dominant-negative Stat1 .
9400721	0	ICAM-1	51,57	intercellular_adhesion_molecule-1	16,49	ICAM-1	intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the lungs of silica-exposed mice .
9434632	0	ICAM-1	63,69	intercellular_adhesion_molecule-1	28,61	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Soluble E-selectin enhances intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human tumor cell lines .
9451527	0	ICAM-1	66,72	intercellular_adhesion_molecule-1	31,64	ICAM-1	intercellular adhesion molecule-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of hyperbaric oxygen on intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in murine lung .
9763331	0	ICAM-1	58,64	intercellular_adhesion_molecule-1	23,56	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	High levels of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in crevicular fluid of periodontitis patients with plaque .
9852101	0	ICAM-1	97,103	intercellular_adhesion_molecule-1	62,95	ICAM-1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lactosylceramide mediates tumor_necrosis_factor-alpha-induced intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression and the adhesion of neutrophil in human umbilical vein endothelial cells .
9875636	0	ICAM-1	64,70	intercellular_adhesion_molecule-1	29,62	ICAM-1	intercellular adhesion molecule-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in organotypic cultures of rat liver tissue .
10413701	0	ICAM-1	54,60	intercellular_adhesion_molecule_1	19,52	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Vitreous levels of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- as a risk indicator of proliferative_vitreoretinopathy .
11006153	0	ICAM-1	49,55	intercellular_adhesion_molecule_1	14,47	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- on the human oviductal epithelium and mediation of lymphoid cell adherence .
1355484	0	ICAM-1	49,55	intercellular_adhesion_molecule_1	14,47	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- during the development of invasion and/or metastasis of gastric_carcinoma .
16076754	0	ICAM-1	79,85	intercellular_adhesion_molecule_1	44,77	ICAM-1	intercellular adhesion molecule 1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Early and long-term effects of radiation on intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in mouse urinary bladder endothelium .
1685745	0	ICAM-1	49,55	intercellular_adhesion_molecule_1	14,47	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in Alzheimer 's _ disease .
16978373	0	ICAM-1	61,67	intercellular_adhesion_molecule_1	26,59	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic influences of the intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene polymorphisms in development of Type_1_diabetes and diabetic_nephropathy .
1722744	0	ICAM-1	49,55	intercellular_adhesion_molecule_1	14,47	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- on human articular cartilage chondrocytes .
19483084	0	ICAM-1	129,135	intercellular_adhesion_molecule_1	94,127	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in endothelial cells .
20647315	0	ICAM-1	83,89	intercellular_adhesion_molecule_1	48,81	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prostaglandin E2/EP1 signaling pathway enhances intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression and cell motility in oral_cancer cells .
2479693	0	ICAM-1	59,65	intercellular_adhesion_molecule_1	24,57	ICAM-1	intercellular adhesion molecule 1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation of the murine intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene .
2576242	0	ICAM-1	96,102	intercellular_adhesion_molecule_1	61,94	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Functional studies of stable L cell transfectants expressing intercellular_adhesion_molecule_1 -LSB- ICAM-1 -RSB- .
2656754	0	ICAM-1	52,58	intercellular_adhesion_molecule_1	17,50	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The induction of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression on human fetal astrocytes by interferon-gamma , _ tumor_necrosis_factor_alpha , lymphotoxin , and interleukin-1 : relevance to intracerebral antigen presentation .
7642556	0	ICAM-1	81,87	intercellular_adhesion_molecule_1	46,79	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	H2O2_and_tumor_necrosis_factor-alpha activate intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter .
7768636	0	ICAM-1	52,58	intercellular_adhesion_molecule_1	17,50	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- on human renal_cell_carcinoma cells by interleukin-4 .
7902311	0	ICAM-1	49,55	intercellular_adhesion_molecule_1	14,47	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 , CD54 -RRB- in colonic epithelial cells .
7911467	0	ICAM-1	155,161	intercellular_adhesion_molecule_1	120,153	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Inhibition of protein_kinase_C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- mRNA by phorbol_esters .
8093883	0	ICAM-1	57,63	intercellular_adhesion_molecule_1	22,55	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	De novo expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 , CD54 -RRB- in pancreas_cancer .
8095960	0	ICAM-1	48,54	intercellular_adhesion_molecule_1	13,46	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in normal human eosinophils by inflammatory cytokines .
8549228	0	ICAM-1	43,49	intercellular_adhesion_molecule_1	8,41	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Soluble intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- antigen in sera of bronchial_asthmatics .
8904994	0	ICAM-1	49,55	intercellular_adhesion_molecule_1	14,47	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression on the human mast-cell line -LRB- HMC -RRB- -1 by inflammatory mediators .
9286030	0	ICAM-1	59,65	intercellular_adhesion_molecule_1	24,57	ICAM-1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Molecular regulation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in renal_cell_carcinoma .
9329027	0	ICAM-1	67,73	intercellular_adhesion_molecule_1	32,65	ICAM-1	intercellular adhesion molecule 1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Enhanced cytokines delivery and intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in glioma by intracarotid infusion of bradykinin analog , RMP-7 .
17019989	0	ICAM-1	71,77	intercellulare_adhesion_molecule	37,69	ICAM-1	intercellulare adhesion molecule	3383	3383	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|expression expression|nmod|END_ENTITY	-LSB- The evaluation of the expression of intercellulare_adhesion_molecule -LRB- ICAM-1 -RRB- by conjunctival epithelial cells of patients with cystic_fibrosis -RSB- .
10050664	0	ICAM-1	47,53	interferon-gamma	101,117	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	molecules|amod|START_ENTITY Expression|nmod|molecules Expression|dep|regulation regulation|nmod|END_ENTITY	Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium : regulation by interferon-gamma .
10975729	0	ICAM-1	51,57	interferon-gamma	104,120	ICAM-1	interferon-gamma	25464(Tax:10116)	25712(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|dep|comparison comparison|nmod|END_ENTITY	Upregulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on rat Schwann cells in vitro : comparison of interferon-gamma , tumor_necrosis_factor-alpha and interleukin-1 .
15212674	0	ICAM-1	66,72	interferon-gamma	92,108	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The differential expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and regulation by interferon-gamma during the pathogenesis of endometriosis .
16695974	0	ICAM-1	48,54	interferon-gamma	14,30	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Activation by interferon-gamma of expression of ICAM-1 and MHC_class_II_antigens in tumour cells from colorectal_carcinomas .
1688067	0	ICAM-1	124,130	interferon-gamma	14,30	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	identity|nmod|START_ENTITY Cloning|dep|identity Cloning|nmod|melanoma-associated_antigen melanoma-associated_antigen|amod|END_ENTITY	Cloning of an interferon-gamma regulated human melanoma-associated_antigen : identity to the intercellular adhesion molecule ICAM-1 .
1982067	0	ICAM-1	63,69	interferon-gamma	105,121	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression crucial|nmod|regulation crucial|nmod|END_ENTITY	Activation of protein kinase C is crucial in the regulation of ICAM-1 expression on endothelial cells by interferon-gamma .
7907595	0	ICAM-1	132,138	interferon-gamma	37,53	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	intercellular_adhesion_molecule-1|dep|START_ENTITY promoter|amod|intercellular_adhesion_molecule-1 proteins|nmod|promoter proteins|amod|END_ENTITY	Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene promoter controls the pattern of expression on epithelial cells .
7908588	0	ICAM-1	105,111	interferon-gamma	46,62	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	formation|amod|START_ENTITY staining|nmod|formation stimulated|dobj|staining stimulated|nsubj|Effects Effects|nmod|toxin toxin|nmod|END_ENTITY	Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol_phosphate formation in a human renal_carcinoma cell line .
7915555	0	ICAM-1	107,113	interferon-gamma	149,165	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	regulation|nmod|START_ENTITY shedding|nsubj|regulation shedding|nmod|END_ENTITY	Various cytokines modulate ICAM-1 shedding on melanoma - and CTCL-derived cell lines : inverse regulation of ICAM-1 shedding in a S zary cell line by interferon-gamma .
7915555	0	ICAM-1	27,33	interferon-gamma	149,165	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	modulate|dobj|START_ENTITY modulate|parataxis|shedding shedding|nmod|END_ENTITY	Various cytokines modulate ICAM-1 shedding on melanoma - and CTCL-derived cell lines : inverse regulation of ICAM-1 shedding in a S zary cell line by interferon-gamma .
8096438	0	ICAM-1	59,65	interferon-gamma	118,134	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	expression|nmod|START_ENTITY expression|dep|protein protein|nmod|cells cells|nmod|END_ENTITY	Amplified expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and M -LRB- r -RRB- 40K protein by DLD-1 colon_tumor cells by interferon-gamma .
8103344	0	ICAM-1	112,118	interferon-gamma	32,48	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	expression|nmod|START_ENTITY expression|amod|protein_kinase_C protein_kinase_C|nmod|END_ENTITY	Role of protein_kinase_C during interferon-gamma - and phorbol_ester-stimulated immunocytochemical expression of ICAM-1 in human renal_carcinoma cells .
8605704	0	ICAM-1	186,192	interferon-gamma	129,145	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	expression|nmod|START_ENTITY enhancement|nmod|expression END_ENTITY|nmod|enhancement	Induction of inflammatory cytokines in effusion cavity by OK-432 injection therapy for patients with malignant_effusion : role of interferon-gamma in enhancement of surface expression of ICAM-1 on tumor cells in vivo .
8608649	0	ICAM-1	152,158	interferon-gamma	179,195	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY proliferation|nmod|intercellular_adhesion_molecule-1 interrupted|nsubjpass|proliferation interrupted|nmod|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- - mediated inhibition of glial cell proliferation and down-regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- are interrupted by interferon-gamma -LRB- IFN-gamma -RRB- .
8670729	0	ICAM-1	66,72	interferon-gamma	83,99	ICAM-1	interferon-gamma	25464(Tax:10116)	25712(Tax:10116)	Gene	Gene	molecule-1|appos|START_ENTITY upregulation|nmod|molecule-1 surface|dobj|upregulation surface|nmod|END_ENTITY	Ocular surface upregulation of intercellular adhesive molecule-1 -LRB- ICAM-1 -RRB- by local interferon-gamma -LRB- IFN-gamma -RRB- in the rat .
8869681	0	ICAM-1	53,59	interferon-gamma	81,97	ICAM-1	interferon-gamma	3383	3458	Gene	Gene	contrary|nmod|START_ENTITY modulated|advmod|contrary modulated|nmod|factor-alpha factor-alpha|compound|END_ENTITY	The vitronectin receptor alpha-V beta-3 , contrary to ICAM-1 , is not modulated by interferon-gamma and tumour necrosis factor-alpha on melanoma cell lines .
10398091	0	ICAM-1	25,31	interleukin-10	175,189	ICAM-1	interleukin-10	3383	3586	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Interferon-gamma-induced ICAM-1 and CD40 expression , complete lack of HLA-DR and CD80 -LRB- B7 .1 -RRB- , and inconsistent HLA-ABC expression in basal_cell_carcinoma : a possible role for interleukin-10 ?
24647791	0	ICAM-1	28,34	interleukin-1b	10,24	ICAM-1	interleukin-1b	3383	3553	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effect of interleukin-1b on ICAM-1 expression of dental pulp cells : role of PI3K/Akt , MEK/ERK , and cyclooxygenase .
17089918	0	ICAM-1	65,71	intracellular_adhesion_molecule_1	30,63	ICAM-1	intracellular adhesion molecule 1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The K469E polymorphism of the intracellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene is not associated with myocardial_infarction in Caucasians with type 2 diabetes .
24576947	0	ICAM-1	39,45	microRNA-223	16,28	ICAM-1	microRNA-223	15894(Tax:10090)	723814(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells .
11532196	0	ICAM-1	128,134	nuclear_factor-kappaB	83,104	ICAM-1	nuclear factor-kappaB	3383	4790	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Different effects of antisense RelA p65 and NF-kappaB1 p50 oligonucleotides on the nuclear_factor-kappaB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells .
12714566	0	ICAM-1	33,39	nuclear_factor-kappaB	130,151	ICAM-1	nuclear factor-kappaB	3383	4790	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Chlamydophila_pneumoniae induces ICAM-1 expression in human aortic endothelial cells via protein_kinase_C-dependent activation of nuclear_factor-kappaB .
12660163	0	ICAM-1	14,20	p53	0,3	ICAM-1	p53	3383	7157	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	p53 activates ICAM-1 -LRB- CD54 -RRB- expression in an NF-kappaB-independent manner .
25026345	0	ICAM-1	121,127	p53	130,133	ICAM-1	p53	3383	7157	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
20823682	0	ICAM-1	167,173	p65	148,151	ICAM-1	p65	15894(Tax:10090)	19697(Tax:10090)	Gene	Gene	promoters|compound|START_ENTITY reducing|nmod|promoters reducing|dobj|recruitment recruitment|amod|END_ENTITY	Amelioration of dextran sulfate_sodium-induced chronic_colitis by sulfasalazine_salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters .
22396143	0	ICAM-1	111,117	platelet_endothelial_cell_adhesion_molecule-1	16,61	ICAM-1	platelet endothelial cell adhesion molecule-1	3383	5175	Gene	Gene	expressions|appos|START_ENTITY expressions|amod|END_ENTITY	Significance of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expressions in preeclamptic placentae .
12783117	0	ICAM-1	35,41	thrombin	72,80	ICAM-1	thrombin	3383	2147	Gene	Gene	expression|appos|START_ENTITY upregulated|nsubjpass|expression upregulated|nmod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is upregulated by thrombin in human monocytes and THP-1 cells in vitro and in pregnant subjects in vivo .
22574597	0	ICAM-1	163,169	toll-like_receptor_4	76,96	ICAM-1	toll-like receptor 4	3383	7099	Gene	Gene	-RSB-|amod|START_ENTITY transduction|dobj|-RSB- signal|acl|transduction signal|amod|END_ENTITY	-LSB- Effects of yiqi huoxue compound contained drug serum on the expressions of toll-like_receptor_4 and downstream signal transduction pathway , and LOX-1 , TNF-alpha , ICAM-1 in the human vein endothelial cells -RSB- .
9185715	0	ICAM-1	24,30	tumor_necrosis_factor	52,73	ICAM-1	tumor necrosis factor	3383	7124	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of ICAM-1 and its induction by tumor_necrosis_factor on breast-cancer cells in vitro .
9414135	0	ICAM-1	55,61	tumor_necrosis_factor	11,32	ICAM-1	tumor necrosis factor	3383	7124	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor and pentoxifylline on ICAM-1 expression on human polymorphonuclear granulocytes .
25026345	0	ICAM-1	121,127	tumor_necrosis_factor-a	32,55	ICAM-1	tumor necrosis factor-a	3383	7124	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dep|expression	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
10769087	0	ICAM-1	87,93	tumor_necrosis_factor-alpha	24,51	ICAM-1	tumor necrosis factor-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	upregulation|nmod|START_ENTITY correlation|appos|upregulation correlation|nmod|release release|amod|END_ENTITY	Temporal correlation of tumor_necrosis_factor-alpha release , upregulation of pulmonary ICAM-1 and VCAM-1 , neutrophil sequestration , and lung_injury in diet-induced pancreatitis .
12738545	0	ICAM-1	25,31	tumor_necrosis_factor-alpha	73,100	ICAM-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	Expression|nmod|START_ENTITY induced|nsubj|Expression induced|nmod|END_ENTITY	Expression of functional ICAM-1 on cultured human keratocytes induced by tumor_necrosis_factor-alpha .
17607964	0	ICAM-1	77,83	tumor_necrosis_factor-alpha	229,256	ICAM-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY -LSB-|nmod|intercellular_adhesion_molecule-1 induced|csubj|-LSB- induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
1980110	0	ICAM-1	82,88	tumor_necrosis_factor-alpha	115,142	ICAM-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	antibody|appos|START_ENTITY modulates|nsubj|antibody modulates|dobj|release release|nmod|END_ENTITY	A monoclonal antibody directed against the human intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- modulates the release of tumor_necrosis_factor-alpha , interferon-gamma and interleukin_1 .
7930472	0	ICAM-1	93,99	tumor_necrosis_factor-alpha	104,131	ICAM-1	tumor necrosis factor-alpha	25464(Tax:10116)	24835(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY rat|dobj|cells rat|nmod|stimulation stimulation|amod|END_ENTITY	Cultured rat hepatic sinusoidal endothelial cells express intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by tumor_necrosis_factor-alpha or interleukin-1_alpha stimulation .
12198772	0	ICAM-1	59,65	uPAR	118,122	ICAM-1	uPAR	25464(Tax:10116)	50692(Tax:10116)	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Decreased expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and urokinase-type plasminogen activator receptor -LRB- uPAR -RRB- is associated with tumor cell spreading in vivo .
8824270	0	ICAM-2	72,78	alpha-actinin	83,96	ICAM-2	alpha-actinin	3384	87	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of the cytoplasmic domain of intercellular_adhesion_molecule-2 -LRB- ICAM-2 -RRB- to alpha-actinin .
24482647	0	ICAM-2	58,64	intercellular_adhesion_molecule-2	23,56	ICAM-2	intercellular adhesion molecule-2	3384	3384	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis of intercellular_adhesion_molecule-2 -LRB- ICAM-2 -RRB- in the context of classical cardiovascular risk factors in acute_coronary_syndrome patients .
9133922	0	ICAM-3	62,68	E-selectin	78,88	ICAM-3	E-selectin	3385	6401	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
16920492	0	ICAM-3	69,75	ICAM-1	14,20	ICAM-3	ICAM-1	3385	3383	Gene	Gene	pathway|compound|START_ENTITY activates|dobj|pathway activates|nsubj|Engagement Engagement|nmod|END_ENTITY	Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1 / ICAM-3 cell adhesion pathway in mononuclear phagocytes .
9133922	0	ICAM-3	62,68	ICAM-1	54,60	ICAM-3	ICAM-1	3385	3383	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|compound|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
9133922	0	ICAM-3	62,68	L-selectin	90,100	ICAM-3	L-selectin	3385	6402	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
10639327	0	ICAM-3	19,25	LFA-1	120,125	ICAM-3	LFA-1	3385	3683	Gene	Gene	interactions|compound|START_ENTITY interactions|dep|cell cell|nmod|redistribution redistribution|nmod|END_ENTITY	Low-affinity LFA-1 / ICAM-3 interactions augment LFA-1 / ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1 .
10639327	0	ICAM-3	19,25	LFA-1	13,18	ICAM-3	LFA-1	3385	3683	Gene	Gene	interactions|compound|START_ENTITY END_ENTITY|dep|interactions	Low-affinity LFA-1 / ICAM-3 interactions augment LFA-1 / ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1 .
10639327	0	ICAM-3	19,25	LFA-1	47,52	ICAM-3	LFA-1	3385	3683	Gene	Gene	interactions|compound|START_ENTITY interactions|dep|END_ENTITY	Low-affinity LFA-1 / ICAM-3 interactions augment LFA-1 / ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1 .
1448173	0	ICAM-3	21,27	LFA-1	48,53	ICAM-3	LFA-1	3385	3683	Gene	Gene	cloning|nmod|START_ENTITY cloning|appos|ligand ligand|nmod|END_ENTITY	Molecular cloning of ICAM-3 , a third ligand for LFA-1 , constitutively expressed on resting leukocytes .
16920492	0	ICAM-3	69,75	LFA-1	63,68	ICAM-3	LFA-1	3385	3683	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1 / ICAM-3 cell adhesion pathway in mononuclear phagocytes .
7516162	0	ICAM-3	22,28	LFA-1	60,65	ICAM-3	LFA-1	3385	3683	Gene	Gene	ICAM-R|appos|START_ENTITY Expression|nmod|ICAM-R Expression|appos|counter-receptor counter-receptor|nmod|END_ENTITY	Expression of ICAM-R -LRB- ICAM-3 -RRB- , a novel counter-receptor for LFA-1 , in rheumatoid_and_nonrheumatoid_synovium .
7531103	0	ICAM-3	22,28	LFA-1	0,5	ICAM-3	LFA-1	3385	3683	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino_acids .
7544645	0	ICAM-3	92,98	LFA-1	78,83	ICAM-3	LFA-1	3385	3683	Gene	Gene	interactions|compound|START_ENTITY ICAM-1|appos|interactions ICAM-1|compound|END_ENTITY	B-cell homotypic adhesion through exon-A restricted epitopes of CD45 involves LFA-1 / ICAM-1 , ICAM-3 interactions , and induces coclustering of CD45 and LFA-1 .
7901223	0	ICAM-3	0,6	LFA-1	22,27	ICAM-3	LFA-1	3385	3683	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ICAM-3 interacts with LFA-1 and regulates the LFA-1 / ICAM-1 cell adhesion pathway .
8223855	0	ICAM-3	0,6	LFA-1	18,23	ICAM-3	LFA-1	3385	3689	Gene	Gene	START_ENTITY|appos|counterreceptor counterreceptor|compound|END_ENTITY	ICAM-3 , the third LFA-1 counterreceptor , is a co-stimulatory molecule for both resting and activated T lymphocytes .
8547030	0	ICAM-3	4,10	LFA-1	11,16	ICAM-3	LFA-1	3385	3683	Gene	Gene	START_ENTITY|parataxis|critical critical|nsubj|interaction interaction|compound|END_ENTITY	The ICAM-3 / LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4 + T cells .
8660847	0	ICAM-3	46,52	LFA-1	40,45	ICAM-3	LFA-1	3385	3683	Gene	Gene	START_ENTITY|dep|mediated mediated|nmod|END_ENTITY	Homotypic interactions mediated through LFA-1 / ICAM-3 decrease the proliferative response of activated T cells .
8707894	0	ICAM-3	6,12	LFA-1	0,5	ICAM-3	LFA-1	3385	3683	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|appos|mediates	LFA-1 / ICAM-3 mediates neutrophil homotypic aggregation under fluid shear stress .
8798624	0	ICAM-3	71,77	LFA-1	125,130	ICAM-3	LFA-1	3385	3683	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|lymphocyte_function-associated_antigen_1 lymphocyte_function-associated_antigen_1|appos|END_ENTITY	Localization of the binding site on intercellular_adhesion_molecule-3 -LRB- ICAM-3 -RRB- for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
9686599	0	ICAM-3	68,74	LFA-1	45,50	ICAM-3	LFA-1	3385	3683	Gene	Gene	residues|compound|START_ENTITY site|nmod|residues leukocyte_function-associated_antigen-1|dep|site leukocyte_function-associated_antigen-1|appos|END_ENTITY	The leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- - binding site on ICAM-3 comprises residues on both faces of the first immunoglobulin domain .
22479382	0	ICAM-3	51,57	intercellular_adhesion_molecule_3	16,49	ICAM-3	intercellular adhesion molecule 3	3385	3385	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	RUNX3 regulates intercellular_adhesion_molecule_3 -LRB- ICAM-3 -RRB- expression during macrophage differentiation and monocyte extravasation .
8798624	0	ICAM-3	71,77	lymphocyte_function-associated_antigen_1	83,123	ICAM-3	lymphocyte function-associated antigen 1	3385	3683	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the binding site on intercellular_adhesion_molecule-3 -LRB- ICAM-3 -RRB- for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
9828136	0	ICAM-5	15,21	telencephalin	23,36	ICAM-5	telencephalin	7087	7087	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping of the ICAM-5 -LRB- telencephalin -RRB- gene , a neuronal member of the ICAM family , to a location between ICAM-1 and ICAM-3 on human chromosome 19p13 .2 .
1372880	0	ICAM1	23,28	CD58	68,72	ICAM1	CD58	3383	965	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elevated expression of ICAM1 -LRB- CD54 -RRB- and minimal expression of LFA3 -LRB- CD58 -RRB- in Epstein-Barr-virus-positive nasopharyngeal_carcinoma cells .
24535541	0	ICAM1	80,85	intercellular_adhesion_molecule-1	45,78	ICAM1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic prediction and diagnostic role of intercellular_adhesion_molecule-1 -LRB- ICAM1 -RRB- expression in clear_cell_renal_cell_carcinoma .
25145994	0	ICAM1	73,78	intercellular_adhesion_molecule-1	38,71	ICAM1	intercellular adhesion molecule-1	3383	3383	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Associations of a polymorphism in the intercellular_adhesion_molecule-1 -LRB- ICAM1 -RRB- gene and ICAM1 serum levels with migraine in a Chinese Han population .
23346076	0	ICAM1	50,55	intercellular_adhesion_molecule_1	15,48	ICAM1	intercellular adhesion molecule 1	3383	3383	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of intercellular_adhesion_molecule_1 -LRB- ICAM1 -RRB- with diabetes and diabetic_nephropathy .
7851905	0	ICAM3	45,50	intercellular_adhesion_molecule_3	10,43	ICAM3	intercellular adhesion molecule 3	3385	3385	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human intercellular_adhesion_molecule_3 -LRB- ICAM3 -RRB- gene is located in the 19p13.2-p13 .3 region , close to the ICAM1 gene .
11854171	0	ICAP-1	52,58	KRIT1	0,5	ICAP-1	KRIT1	9270	889	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	KRIT1 association with the integrin-binding protein ICAP-1 : a new direction in the elucidation of cerebral_cavernous_malformations -LRB- CCM1 -RRB- pathogenesis .
21885566	0	ICAT	33,37	androgen_receptor	48,65	ICAT	androgen receptor	56998	367	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	The beta-catenin binding protein ICAT modulates androgen_receptor activity .
15148409	0	ICAT	79,83	beta-catenin	47,59	ICAT	beta-catenin	56998	1499	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor -LRB- ICAT -RRB- , a negative regulator of Wnt signaling .
12408825	0	ICAT	0,4	p300	103,107	ICAT	p300	56998	2033	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules .
17934516	0	ICBP90	37,43	DNMT1	67,72	ICBP90	DNMT1	29128	1786	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression .
15361834	0	ICBP90	0,6	E2F-1	11,16	ICBP90	E2F-1	29128	1869	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	ICBP90 , an E2F-1 target , recruits HDAC1 and binds to methyl-CpG through its SRA domain .
19328461	0	ICBP90	0,6	ERK1/2	20,26	ICBP90	ERK1/2	29128	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	ICBP90 mediates the ERK1/2 signaling to regulate the proliferation of Jurkat T cells .
15361834	0	ICBP90	0,6	HDAC1	34,39	ICBP90	HDAC1	29128	3065	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	ICBP90 , an E2F-1 target , recruits HDAC1 and binds to methyl-CpG through its SRA domain .
26752645	0	ICBP90	21,27	MIF	42,45	ICBP90	MIF	29128	4282	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|promoter promoter|compound|END_ENTITY	Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus .
9427519	0	ICE	51,54	interleukin-1_beta-converting_enzyme	13,49	ICE	interleukin-1 beta-converting enzyme	12362(Tax:10090)	12362(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of interleukin-1_beta-converting_enzyme -LRB- ICE -RRB- in murine microglia by lipopolysaccharide .
8034321	0	ICE	113,116	interleukin-1_beta_converting_enzyme	75,111	ICE	interleukin-1 beta converting enzyme	12362(Tax:10090)	12362(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The structure and complete nucleotide sequence of the murine gene encoding interleukin-1_beta_converting_enzyme -LRB- ICE -RRB- .
9987822	0	ICE	52,55	interleukin-1_beta_converting_enzyme	14,50	ICE	interleukin-1 beta converting enzyme	12362(Tax:10090)	12362(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Peptide based interleukin-1_beta_converting_enzyme -LRB- ICE -RRB- inhibitors : synthesis , structure activity relationships and crystallographic study of the ICE-inhibitor complex .
10359086	0	ICE	91,94	interleukin-1beta-converting_enzyme	54,89	ICE	interleukin-1beta-converting enzyme	834	834	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Defective binding of IRFs to the initiator element of interleukin-1beta-converting_enzyme -LRB- ICE -RRB- promoter in an interferon-resistant Daudi subline .
9104815	0	ICE	80,83	interleukin-1beta-converting_enzyme	43,78	ICE	interleukin-1beta-converting enzyme	834	834	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Human vascular smooth muscle cells express interleukin-1beta-converting_enzyme -LRB- ICE -RRB- , but inhibit processing of the interleukin-1beta precursor by ICE .
14598973	0	ICE	46,49	interleukin-1beta_converting_enzyme	9,44	ICE	interleukin-1beta converting enzyme	834	834	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Impaired interleukin-1beta_converting_enzyme -LRB- ICE -RRB- activity in patients with pulmonary_tuberculosis .
16782334	0	ICE	126,129	interleukin-1beta_converting_enzyme	89,124	ICE	interleukin-1beta converting enzyme	834	834	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and evaluation of novel 1 - -LRB- 2-acylhydrazinocarbonyl -RRB- - cycloalkyl_carboxamides as interleukin-1beta_converting_enzyme -LRB- ICE -RRB- inhibitors .
16870441	0	ICE	80,83	interleukin-1beta_converting_enzyme	43,78	ICE	interleukin-1beta converting enzyme	834	834	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and evaluation of thiazepines as interleukin-1beta_converting_enzyme -LRB- ICE -RRB- inhibitors .
17127070	0	ICE	93,96	interleukin-1beta_converting_enzyme	56,91	ICE	interleukin-1beta converting enzyme	834	834	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta_converting_enzyme -LRB- ICE -RRB- inhibitors .
8805307	0	ICE-LAP3	69,77	granzyme_B	25,35	ICE-LAP3	granzyme B	840	3002	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Cytotoxic T-cell-derived granzyme_B activates the apoptotic protease ICE-LAP3 .
8663294	0	ICE-LAP6	0,8	granzyme_B	101,111	ICE-LAP6	granzyme B	842	3002	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	ICE-LAP6 , a novel member of the ICE/Ced -3 gene family , is activated by the cytotoxic T cell protease granzyme_B .
25669882	0	ICE1	54,58	OST1	0,4	ICE1	OST1	822287(Tax:3702)	829541(Tax:3702)	Gene	Gene	stability|compound|START_ENTITY enhancing|dobj|stability modulates|advcl|enhancing modulates|nsubj|kinase kinase|compound|END_ENTITY	OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis .
25680856	0	ICE1	20,24	OST1	0,4	ICE1	OST1	23379	6184	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	OST1 phosphorylates ICE1 to enhance plant cold tolerance .
26835742	0	ICER	90,94	ERK1/2	69,75	ICER	ERK1/2	25620(Tax:10116)	50689;116590	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	GnRH Pulse Frequency Control of Fshb Gene Expression Is Mediated via ERK1/2 Regulation of ICER .
11002260	0	ICER	110,114	inducible_cAMP_early_repressor	78,108	ICER	inducible cAMP early repressor	1390	1390	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Repression of tax-mediated human_t-lymphotropic_virus_type_1 transcription by inducible_cAMP_early_repressor -LRB- ICER -RRB- protein in peripheral blood mononuclear cells .
8750826	0	ICER	46,50	inducible_cAMP_early_repressor	14,44	ICER	inducible cAMP early repressor	1390	1390	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of inducible_cAMP_early_repressor -LRB- ICER -RRB- in hypothalamic magnocellular neurons .
9359831	0	ICER	51,55	inducible_cAMP_early_repressor	19,49	ICER	inducible cAMP early repressor	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	Degradation|appos|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of the inducible_cAMP_early_repressor -LRB- ICER -RRB- by the ubiquitin-proteasome pathway .
15384069	0	ICER	74,78	inducible_cyclicAMP_early_repressor	37,72	ICER	inducible cyclicAMP early repressor	1390	1390	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of transcription factor inducible_cyclicAMP_early_repressor -LRB- ICER -RRB- in rodent brain and pituitary .
9523727	0	ICERE-1	91,98	estrogen_receptor	61,78	ICERE-1	estrogen receptor	1687	2099	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Characterization of a gene that is inversely correlated with estrogen_receptor expression -LRB- ICERE-1 -RRB- in breast_carcinomas .
20674352	0	ICE_or_caspase_1	51,67	interleukin-1beta_converting_enzyme	14,49	ICE or caspase 1	interleukin-1beta converting enzyme	834	834	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of interleukin-1beta_converting_enzyme -LRB- ICE_or_caspase_1 -RRB- by aspartyl_acyloxyalkyl_ketones and aspartyl_amidooxyalkyl_ketones .
9753775	0	ICK1	0,4	Cdc2a	96,101	ICK1	Cdc2a	816875(Tax:3702)	824036(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ICK1 , a cyclin-dependent protein kinase inhibitor from Arabidopsis_thaliana interacts with both Cdc2a and CycD3 , and its expression is induced by abscisic_acid .
10758489	0	ICK1	74,78	ICK2	42,46	ICK1	ICK2	816875(Tax:3702)	824226(Tax:3702)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	The Arabidopsis Cdc2a-interacting protein ICK2 is structurally related to ICK1 and is a potent inhibitor of cyclin-dependent kinase activity in vitro .
10758489	0	ICK2	42,46	ICK1	74,78	ICK2	ICK1	824226(Tax:3702)	816875(Tax:3702)	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	The Arabidopsis Cdc2a-interacting protein ICK2 is structurally related to ICK1 and is a potent inhibitor of cyclin-dependent kinase activity in vitro .
11007762	0	ICOS	103,107	B7RP-1	52,58	CD28	B7RP-1	940	50723(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|protein protein|dep|END_ENTITY	Characterization of a new human B7-related protein : B7RP-1 is the ligand to the co-stimulatory protein ICOS .
12853164	0	ICOS	37,41	B7RP-1	65,71	ICOS	B7RP-1	54167(Tax:10090)	50723(Tax:10090)	Gene	Gene	inducible_co-stimulator|appos|START_ENTITY role|nmod|inducible_co-stimulator role|parataxis|interaction interaction|nsubj|B7-related_protein-1 B7-related_protein-1|appos|END_ENTITY	The role of inducible_co-stimulator -LRB- ICOS -RRB- / B7-related_protein-1 -LRB- B7RP-1 -RRB- interaction in the functional development of Peyer 's patches .
15361696	0	ICOS	19,23	B7RP-1	12,18	ICOS	B7RP-1	54167(Tax:10090)	50723(Tax:10090)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of the B7RP-1 / ICOS pathway in renal tubular epithelial antigen presentation to CD4 + Th1 and Th2 cells .
20136724	0	ICOS	23,27	B7RP-1	16,22	ICOS	B7RP-1	54167(Tax:10090)	50723(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|/ /|compound|END_ENTITY	Contribution of B7RP-1 / ICOS co-stimulation to lethal acute GVHD .
10760791	0	ICOS	49,53	B7h	76,79	ICOS	B7h	54167(Tax:10090)	50723(Tax:10090)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS_ligand .
25436971	0	ICOS	45,49	Bcl-6	63,68	ICOS	Bcl-6	29851	604	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	A p85a-osteopontin axis couples the receptor ICOS to sustained Bcl-6 expression by follicular helper and regulatory T cells .
26231034	0	ICOS	17,21	CCR7	12,16	ICOS	CCR7	29851	1236	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Circulating CCR7 + ICOS + Memory T Follicular Helper Cells in Patients with Multiple_Sclerosis .
15184501	0	ICOS	42,46	CD25	4,8	ICOS	CD25	29851	3559	Gene	Gene	dependent|nmod|START_ENTITY cells|amod|dependent cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic_lesion .
19448155	0	ICOS	32,36	CD25	21,25	ICOS	CD25	54167(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
22815292	0	ICOS	0,4	CD25	49,53	ICOS	CD25	54167(Tax:10090)	16184(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|generation generation|nmod|Foxp3 Foxp3|compound|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
11046032	0	ICOS	40,44	CD28	72,76	ICOS	CD28	54167(Tax:10090)	12487(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY enhanced|nsubjpass|expression enhanced|nmod|costimulation costimulation|compound|END_ENTITY	Mouse inducible_costimulatory molecule -LRB- ICOS -RRB- expression is enhanced by CD28 costimulation and regulates differentiation of CD4 + T cells .
17013990	0	ICOS	0,4	CD28	21,25	ICOS	CD28	29851	940	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	ICOS cooperates with CD28 , IL-2 , and IFN-gamma and modulates activation of human na ve CD4 + T cells .
26098894	0	ICOS	104,108	CD28	64,68	ICOS	CD28	54167(Tax:10090)	12487(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Independent|nmod|Expression Independent|nsubj|Inhibition Inhibition|nmod|Responses Responses|nmod|Blockade Blockade|compound|END_ENTITY	Inhibition of Donor-Reactive CD8 + T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression .
12538658	0	ICOS	14,18	CD4	35,38	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY defines|nsubj|Expression defines|dobj|cells cells|nummod|END_ENTITY	Expression of ICOS in vivo defines CD4 + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin_10 .
15184501	0	ICOS	42,46	CD4	0,3	ICOS	CD4	29851	920	Gene	Gene	dependent|nmod|START_ENTITY cells|amod|dependent cells|compound|END_ENTITY	CD4 + CD25 + T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic_lesion .
15361696	0	ICOS	19,23	CD4	84,87	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Th1 Th1|compound|END_ENTITY	Role of the B7RP-1 / ICOS pathway in renal tubular epithelial antigen presentation to CD4 + Th1 and Th2 cells .
16500623	0	ICOS	16,20	CD4	30,33	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Upregulation of ICOS on CD43 + CD4 + murine small intestinal intraepithelial lymphocytes during acute reovirus_infection .
16751384	0	ICOS	20,24	CD4	66,69	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubj|effects mediated|nmod|cells cells|compound|END_ENTITY	Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells .
17549732	0	ICOS	12,16	CD4	39,42	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|development development|nmod|help help|compound|END_ENTITY	The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells .
18292519	0	ICOS	14,18	CD4	50,53	ICOS	CD4	29851	920	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Expression of ICOS on human melanoma-infiltrating CD4 + CD25highFoxp3 + T regulatory cells : implications and impact on tumor-mediated immune suppression .
18310064	0	ICOS	4,8	CD4	0,3	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + ICOS + T lymphocytes inhibit T cell activation ` in vitro ' and attenuate autoimmune_encephalitis ` in vivo ' .
18941193	0	ICOS	161,165	CD4	156,159	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
19376499	0	ICOS	47,51	CD4	78,81	ICOS	CD4	29851	920	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T-cell dysfunction in patients with active SLE .
19448155	0	ICOS	32,36	CD4	17,20	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
20116985	0	ICOS	85,89	CD4	14,17	ICOS	CD4	29851	920	Gene	Gene	inducible_costimulator|appos|START_ENTITY function|nmod|inducible_costimulator function|nsubj|Regulation Regulation|nmod|activation activation|compound|END_ENTITY	Regulation of CD4 T cell activation and effector function by inducible_costimulator -LRB- ICOS -RRB- .
21364749	0	ICOS	49,53	CD4	27,30	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	depend|nmod|START_ENTITY depend|nsubj|cells cells|nummod|END_ENTITY	Protective effector memory CD4 T cells depend on ICOS for survival .
21558138	0	ICOS	26,30	CD4	21,24	ICOS	CD4	29851	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
22371394	0	ICOS	33,37	CD4	0,3	ICOS	CD4	29851	920	Gene	Gene	mediate|dobj|START_ENTITY type|ccomp|mediate type|nsubj|END_ENTITY	CD4 -LRB- + -RRB- type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes .
22661090	0	ICOS	121,125	CD4	26,29	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY reveals|dobj|role reveals|nsubj|analysis analysis|nmod|cells cells|nummod|END_ENTITY	Comprehensive analysis of CD4 + T cells in the decision between tolerance and immunity in vivo reveals a pivotal role for ICOS .
22815292	0	ICOS	0,4	CD4	45,48	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|generation generation|nmod|Foxp3 Foxp3|compound|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
23316652	0	ICOS	28,32	CD4	36,39	ICOS	CD4	29851	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	-LSB- Expression and function of ICOS on CD4 T cells and application to therapy in patients with ocular Beh __ et 's _ disease with uveitis -RSB- .
23802069	0	ICOS	0,4	CD4	110,113	ICOS	CD4	29851	920	Gene	Gene	associated|nsubjpass|START_ENTITY associated|advcl|promotes promotes|dobj|cells cells|compound|amplification amplification|nmod|T T|compound|END_ENTITY	ICOS is associated with poor prognosis in breast_cancer as it promotes the amplification of immunosuppressive CD4 -LRB- + -RRB- T cells by plasmacytoid dendritic cells .
23923047	0	ICOS	53,57	CD4	61,64	ICOS	CD4	29851	920	Gene	Gene	differentiation|nmod|START_ENTITY differentiation|dep|cells cells|compound|END_ENTITY	STAT3 signaling induces the differentiation of human ICOS -LRB- + -RRB- CD4 T cells helping B lymphocytes .
24312642	0	ICOS	0,4	CD4	52,55	ICOS	CD4	29851	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|generation generation|nmod|Treg Treg|compound|END_ENTITY	ICOS regulates the generation and function of human CD4 + Treg in a CTLA-4 dependent manner .
25754933	0	ICOS	0,4	CD4	65,68	ICOS	CD4	54167(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|generation generation|nmod|populations populations|amod|END_ENTITY	ICOS is required for the generation of both central and effector CD4 -LRB- + -RRB- memory T-cell populations following acute bacterial_infection .
25918344	0	ICOS	0,4	CD4	44,47	ICOS	CD4	733597(Tax:9823)	404704(Tax:9823)	Gene	Gene	maintain|nsubj|START_ENTITY maintain|dobj|population population|compound|END_ENTITY	ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis .
25918344	0	ICOS	0,4	CD4	44,47	ICOS	CD4	733597(Tax:9823)	404704(Tax:9823)	Gene	Gene	maintain|nsubj|START_ENTITY maintain|dobj|population population|compound|END_ENTITY	ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis .
16500623	0	ICOS	16,20	CD43	24,28	ICOS	CD43	54167(Tax:10090)	20737(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Upregulation of ICOS on CD43 + CD4 + murine small intestinal intraepithelial lymphocytes during acute reovirus_infection .
16081804	0	ICOS	12,16	CXCR5	24,29	ICOS	CXCR5	54167(Tax:10090)	12145(Tax:10090)	Gene	Gene	START_ENTITY|nmod|helper helper|compound|END_ENTITY	The role of ICOS in the CXCR5 + follicular B helper T cell maintenance in vivo .
18941193	0	ICOS	161,165	CXCR5	167,172	ICOS	CXCR5	54167(Tax:10090)	12145(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
19448155	0	ICOS	32,36	Foxp3	26,31	ICOS	Foxp3	54167(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Flt3-L increases CD4 + CD25 + Foxp3 + ICOS + cells in the lungs of cockroach-sensitized and - challenged mice .
21558138	0	ICOS	26,30	Foxp3	32,37	ICOS	Foxp3	29851	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
22815292	0	ICOS	0,4	Foxp3	54,59	ICOS	Foxp3	54167(Tax:10090)	20371(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|generation generation|nmod|END_ENTITY	ICOS mediates the generation and function of CD4 + CD25 + Foxp3 + regulatory T cells conveying respiratory tolerance .
22850422	0	ICOS	77,81	Foxp3	99,104	ICOS	Foxp3	29851	50943	Gene	Gene	costimulation|compound|START_ENTITY costimulation|nmod|END_ENTITY	Plasmacytoid dendritic cells promote immunosuppression in ovarian_cancer via ICOS costimulation of Foxp3 -LRB- + -RRB- T-regulatory cells .
23319295	0	ICOS	0,4	Foxp3	14,19	ICOS	Foxp3	54167(Tax:10090)	20371(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|xcomp|production production|nsubj|END_ENTITY	ICOS controls Foxp3 -LRB- + -RRB- regulatory T-cell expansion , maintenance and IL-10 production during helminth infection .
25946021	0	ICOS	9,13	Foxp3	15,20	ICOS	Foxp3	54167(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|CXCR3 CXCR3|amod|END_ENTITY	Th1-Like ICOS + Foxp3 + Treg Cells Preferentially Express CXCR3 and Home to b-Islets during Pre-Diabetes in BDC2 .5 NOD Mice .
25946021	0	ICOS	9,13	Foxp3	15,20	ICOS	Foxp3	54167(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|dobj|CXCR3 CXCR3|amod|END_ENTITY	Th1-Like ICOS + Foxp3 + Treg Cells Preferentially Express CXCR3 and Home to b-Islets during Pre-Diabetes in BDC2 .5 NOD Mice .
25769613	0	ICOS	0,4	ICOS-ligand	5,16	ICOS	ICOS-ligand	29851	102723996	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	ICOS : ICOS-ligand interaction is required for type 2 innate lymphoid cell function , homeostasis , and induction of airway_hyperreactivity .
12207353	0	ICOS	0,4	IL-10	33,38	ICOS	IL-10	29851	3586	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells .
21558138	0	ICOS	26,30	IL-10	79,84	ICOS	IL-10	29851	3586	Gene	Gene	cells|compound|START_ENTITY contribute|nsubj|cells contribute|nmod|overproduction overproduction|nmod|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
18941193	0	ICOS	161,165	IL-17	149,154	ICOS	IL-17	54167(Tax:10090)	16171(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
19889730	0	ICOS	0,4	IL-17	14,19	ICOS	IL-17	54167(Tax:10090)	16171(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|synthesis synthesis|compound|END_ENTITY	ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10 - / - mice .
19098919	0	ICOS	27,31	c-Maf	60,65	ICOS	c-Maf	54167(Tax:10090)	17132(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells .
23138463	0	ICOS	126,130	cytotoxic_T_lymphocyte-associated_antigen-4	44,87	ICOS	cytotoxic T lymphocyte-associated antigen-4	29851	1493	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Association of Hashimoto 's _ thyroiditis with cytotoxic_T_lymphocyte-associated_antigen-4 -LRB- CTLA-4 -RRB- and inducible_co-stimulator -LRB- ICOS -RRB- genes in a Kuwaiti population .
19125271	0	ICOS	44,48	inducible_co-stimulator	19,42	ICOS	inducible co-stimulator	64545(Tax:10116)	64545(Tax:10116)	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of inducible_co-stimulator -LRB- ICOS -RRB- by intravitreal injection of small interfering RNA -LRB- siRNA -RRB- plasmid suppresses ongoing experimental autoimmune uveoretinitis in rats .
12753665	0	ICOS	49,53	inducible_costimulator	25,47	ICOS	inducible costimulator	29851	29851	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Allelic variation of the inducible_costimulator -LRB- ICOS -RRB- gene : detection of polymorphisms , analysis of the promoter region , and extended haplotype estimation .
15941568	0	ICOS	46,50	inducible_costimulator	22,44	ICOS	inducible costimulator	54167(Tax:10090)	54167(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A functional role for inducible_costimulator -LRB- ICOS -RRB- in atherosclerosis .
16880206	0	ICOS	44,48	inducible_costimulator	20,42	ICOS	inducible costimulator	54167(Tax:10090)	54167(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of mouse inducible_costimulator -LRB- ICOS -RRB- expression by Fyn-NFATc2 and ERK signaling in T cells .
24100657	0	ICOS-L	40,46	inducible_costimulator_ligand	9,38	ICOS-L	inducible costimulator ligand	50723(Tax:10090)	50723(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Enhanced inducible_costimulator_ligand -LRB- ICOS-L -RRB- expression on dendritic cells in interleukin-10_deficiency and its impact on T-cell subsets in respiratory_tract_infection .
25769613	0	ICOS-ligand	5,16	ICOS	0,4	ICOS-ligand	ICOS	102723996	29851	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	ICOS : ICOS-ligand interaction is required for type 2 innate lymphoid cell function , homeostasis , and induction of airway_hyperreactivity .
22706735	0	ICOSL	46,51	inducible_costimulator_ligand	15,44	ICOSL	inducible costimulator ligand	23308	23308	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Involvement of inducible_costimulator_ligand -LRB- ICOSL -RRB- expression in thyroid tissue in hyperthyroidism of Graves ' _ disease patients .
25210803	0	ICOS_ligand	121,132	interleukin-2	92,105	ICOS ligand	interleukin-2	102723996	3558	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS_ligand .
12393690	0	ICSBP	19,24	CD8alpha	62,70	ICSBP	CD8alpha	15900(Tax:10090)	12525(Tax:10090)	Gene	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells .
11823414	0	ICSBP	45,50	Disabled-2	0,10	ICSBP	Disabled-2	15900(Tax:10090)	13132(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion .
15688197	0	ICSBP	17,22	IRF-8	24,29	ICSBP	IRF-8	292060(Tax:10116)	292060(Tax:10116)	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Analysis of PU .1 / ICSBP -LRB- IRF-8 -RRB- complex formation with various PU .1 mutants : molecular cloning of rat Icsbp -LRB- Irf-8 -RRB- cDNA .
19147015	0	ID-1	36,40	PAI-1	30,35	ID-1	PAI-1	3397	5054	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	Ionizing radiation shifts the PAI-1 / ID-1 balance and activates notch signaling in endothelial cells .
19255251	0	ID1	39,42	Probasin	0,8	ID1	Probasin	15901(Tax:10090)	54192(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Probasin promoter-driven expression of ID1 is not sufficient for carcinogenesis in rodent prostate .
22698403	0	ID1	0,3	p21	94,97	ID1	p21	3397	644914	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	ID1 and ID3 regulate the self-renewal capacity of human colon_cancer-initiating cells through p21 .
20861012	0	ID2	30,33	CLOCK	83,88	ID2	CLOCK	15902(Tax:10090)	12753(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression .
17431671	0	ID2	37,40	OLIG2	26,31	ID2	OLIG2	3398	10215	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Predominant expression of OLIG2 over ID2 in oligodendroglial_tumors .
21478550	0	ID2	69,72	inhibitor_of_DNA_binding_2	41,67	ID2	inhibitor of DNA binding 2	3398	3398	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Large scale RNAi screen reveals that the inhibitor_of_DNA_binding_2 -LRB- ID2 -RRB- protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation .
18372118	0	ID3	36,39	BMP4	10,14	ID3	BMP4	3399	652	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Autocrine BMP4 signalling regulates ID3 proto-oncogene expression in human ovarian_cancer cells .
18575765	0	ID4	73,76	Cdc42	0,5	ID4	Cdc42	3400	998	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Cdc42 is highly expressed in colorectal_adenocarcinoma and downregulates ID4 through an epigenetic mechanism .
23613880	0	ID4	27,30	TP53	56,60	ID4	TP53	3400	7157	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|levels levels|compound|END_ENTITY	Differential expression of ID4 and its association with TP53 mutation , SOX2 , SOX4 and OCT-4 expression levels .
11086294	0	IDA-1	0,5	IA-2_and_phogrin	69,85	IDA-1	IA-2 and phogrin	175807(Tax:6239)	5798	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	IDA-1 , a Caenorhabditis_elegans homolog of the diabetic autoantigens IA-2_and_phogrin , is expressed in peptidergic neurons in the worm .
2567260	0	IDDM	39,43	insulin	4,11	IDDM	insulin	3630	3630	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The insulin gene and susceptibility to IDDM .
3525270	0	IDDM	54,58	insulin	31,38	IDDM	insulin	3630	3630	Gene	Gene	requirement|nmod|START_ENTITY requirement|compound|END_ENTITY	The effects of sucrose meal on insulin requirement in IDDM and its modulation by acarbose .
8772720	0	IDDM	40,44	phogrin	85,92	IDDM	phogrin	3630	5799	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein -LRB- phogrin -RRB- related to IA-2 .
8734569	0	IDDM1	80,85	Lyp	107,110	IDDM1	Lyp	326381(Tax:10116)	326380(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	T cells from BB-DP rats show a unique cytokine mRNA profile associated with the IDDM1 susceptibility gene , Lyp .
7773292	0	IDDM2	55,60	insulin	71,78	IDDM2	insulin	3630	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription .
15922563	0	IDDM2	107,112	lyp	118,121	IDDM2	lyp	326380(Tax:10116)	326380(Tax:10116)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 -LRB- the lyp gene -RRB- and partly associated with other genes in the BB rat background .
14679087	0	IDDM_17	45,52	Caspase_7	0,9	IDDM 17	Caspase 7	8691	840	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Caspase_7 is a positional candidate gene for IDDM_17 in a Bedouin Arab family .
12716770	0	IDE	68,71	insulin-degrading_enzyme	42,66	IDE	insulin-degrading enzyme	3416	3416	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association and haplotype analysis of the insulin-degrading_enzyme -LRB- IDE -RRB- gene , a strong positional and biological candidate for type 2 diabetes susceptibility .
15277398	0	IDE	59,62	insulin-degrading_enzyme	33,57	IDE	insulin-degrading enzyme	3416	3416	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Quantitative trait loci near the insulin-degrading_enzyme -LRB- IDE -RRB- gene contribute to variation in plasma insulin levels .
16380485	0	IDE	90,93	insulin-degrading_enzyme	64,88	IDE	insulin-degrading enzyme	3416	3416	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High-density haplotype structure and association testing of the insulin-degrading_enzyme -LRB- IDE -RRB- gene with type 2 diabetes in 4,206 people .
16914266	0	IDE	79,82	insulin-degrading_enzyme	53,77	IDE	insulin-degrading enzyme	3416	3416	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association of 5 SNPs in the vicinity of the insulin-degrading_enzyme -LRB- IDE -RRB- gene with late-onset Alzheimer 's _ disease .
17613531	0	IDE	130,133	insulin-degrading_enzyme	34,58	IDE	insulin-degrading enzyme	3416	3416	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of substrate-free human insulin-degrading_enzyme -LRB- IDE -RRB- and biophysical analysis of ATP-induced conformational switch of IDE .
25043045	0	IDH	7,10	HNF-4a	20,26	IDH	HNF-4a	15926(Tax:10090)	15378(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary_cancer .
25607362	0	IDH	20,23	HNF-4a	33,39	IDH	HNF-4a	3417	3172	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Corrigendum : Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary_cancer .
26580013	0	IDH	20,23	HNF-4a	33,39	IDH	HNF-4a	3417	3172	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Corrigendum : Mutant IDH inhibits HNF-4a to block hepatocyte differentiation and promote biliary_cancer .
24469454	0	IDH	75,78	Isocitrate_Dehydrogenase	49,73	IDH	Isocitrate Dehydrogenase	3417	3417	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of ten-eleven_translocation_1 -LRB- TET1 -RRB- , Isocitrate_Dehydrogenase -LRB- IDH -RRB- expression , a-Ketoglutarate -LRB- a-KG -RRB- , and DNA hydroxymethylation levels by interleukin-1b in primary human chondrocytes .
26245674	0	IDH	99,102	Isocitrate_Dehydrogenase	73,97	IDH	Isocitrate Dehydrogenase	3417	3417	Gene	Gene	Mutant|compound|START_ENTITY Mutant|compound|END_ENTITY	Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate_Dehydrogenase -LRB- IDH -RRB- Mutant and IDH Wild-Type_Intrahepatic_Cholangiocarcinoma .
26245674	0	IDH	99,102	Isocitrate_Dehydrogenase	73,97	IDH	Isocitrate Dehydrogenase	3417	3417	Gene	Gene	Mutant|compound|START_ENTITY Mutant|compound|END_ENTITY	Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate_Dehydrogenase -LRB- IDH -RRB- Mutant and IDH Wild-Type_Intrahepatic_Cholangiocarcinoma .
22489043	0	IDH1	41,45	CBL	28,31	IDH1	CBL	3417	867	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH1	41,45	DNMT3A	33,39	IDH1	DNMT3A	3417	1788	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH1	41,45	IDH2	47,51	IDH1	IDH2	3417	3418	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
24887488	0	IDH1	40,44	IDH2	46,50	IDH1	IDH2	3417	3418	Gene	Gene	DNMT3A|nummod|START_ENTITY DNMT3A|nummod|END_ENTITY	Mutation and expression analysis of the IDH1 , IDH2 , DNMT3A , and MYD88 genes in colorectal_cancer .
26562302	0	IDH1	28,32	IDH2	34,38	IDH1	IDH2	3417	3418	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
24760710	0	IDH1	28,32	Isocitrate_dehydrogenase_1	0,26	IDH1	Isocitrate dehydrogenase 1	3417	3417	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Isocitrate_dehydrogenase_1 -LRB- IDH1 -RRB- mutation in breast_adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate .
22489043	0	IDH1	41,45	JAK2	53,57	IDH1	JAK2	3417	3717	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH1	41,45	MPL	59,62	IDH1	MPL	3417	4352	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH1	41,45	NF1	64,67	IDH1	NF1	3417	4763	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH1	41,45	SF3B1	69,74	IDH1	SF3B1	3417	23451	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
26562302	0	IDH1	28,32	SF3B1	47,52	IDH1	SF3B1	3417	23451	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
26562302	0	IDH1	28,32	SRSF2	40,45	IDH1	SRSF2	3417	6427	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
23011765	0	IDH1	31,35	U87	45,48	IDH1	U87	3417	641648	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of R132H mutational IDH1 in human U87 glioblastoma cells affects the SREBP1a pathway and induces cellular proliferation .
26770405	0	IDH1	35,39	U87	69,72	IDH1	U87	3417	641648	Gene	Gene	START_ENTITY|nmod|gene-chip gene-chip|nmod|END_ENTITY	Identifying the genes regulated by IDH1 via gene-chip in glioma cell U87 .
22076165	0	IDH1	93,97	isocitrate_dehydrogenase_1	65,91	IDH1	isocitrate dehydrogenase 1	3417	3417	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Glioblastoma with PNET-like components has a higher frequency of isocitrate_dehydrogenase_1 -LRB- IDH1 -RRB- mutation and likely a better prognosis than primary_glioblastoma .
23235339	0	IDH1	65,69	isocitrate_dehydrogenase_1	37,63	IDH1	isocitrate dehydrogenase 1	3417	3417	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Immunohistochemical demonstration of isocitrate_dehydrogenase_1 -LRB- IDH1 -RRB- mutation in a small subset of prostatic_carcinomas .
23934769	0	IDH1	39,43	isocitrate_dehydrogenase_1	45,71	IDH1	isocitrate dehydrogenase 1	3417	3417	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	An analysis of the prognostic value of IDH1 -LRB- isocitrate_dehydrogenase_1 -RRB- mutation in Polish glioma patients .
25135281	0	IDH1	82,86	prostate_apoptosis_response-4	21,50	IDH1	prostate apoptosis response-4	3417	5074	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The tumor suppressor prostate_apoptosis_response-4 -LRB- Par-4 -RRB- is regulated by mutant IDH1 and kills glioma stem cells .
26486081	0	IDH1/2	0,6	DNMT3A	15,21	IDH1/2	DNMT3A	3417;3418	1788	Gene	Gene	START_ENTITY|nmod|mutations mutations|nummod|END_ENTITY	IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients : a study by the acute leukemia french association .
22489043	0	IDH2	47,51	CBL	28,31	IDH2	CBL	3418	867	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH2	47,51	DNMT3A	33,39	IDH2	DNMT3A	3418	1788	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH2	47,51	IDH1	41,45	IDH2	IDH1	3418	3417	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
24887488	0	IDH2	46,50	IDH1	40,44	IDH2	IDH1	3418	3417	Gene	Gene	DNMT3A|nummod|START_ENTITY DNMT3A|nummod|END_ENTITY	Mutation and expression analysis of the IDH1 , IDH2 , DNMT3A , and MYD88 genes in colorectal_cancer .
26562302	0	IDH2	34,38	IDH1	28,32	IDH2	IDH1	3418	3417	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
22489043	0	IDH2	47,51	JAK2	53,57	IDH2	JAK2	3418	3717	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH2	47,51	MPL	59,62	IDH2	MPL	3418	4352	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH2	47,51	NF1	64,67	IDH2	NF1	3418	4763	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	IDH2	47,51	SF3B1	69,74	IDH2	SF3B1	3418	23451	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
26562302	0	IDH2	34,38	SF3B1	47,52	IDH2	SF3B1	3418	23451	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
26562302	0	IDH2	34,38	SRSF2	40,45	IDH2	SRSF2	3418	6427	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
23815907	0	IDH2	41,45	isocitrate_dehydrogenase_2	13,39	IDH2	isocitrate dehydrogenase 2	3418	3418	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Mutation of isocitrate_dehydrogenase_2 -LRB- IDH2 -RRB- gene in Chinese AML patients and its clinical significance -RSB- .
26657115	0	IDO	32,35	IL-27	0,5	IDO	IL-27	3620	246778	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-27 induces the expression of IDO and PD-L1 in human cancer cells .
17661345	0	IDO	18,21	IL-4	85,89	IDO	IL-4	3620	3565	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4 .
19597340	0	IDO	0,3	Vav1	49,53	IDO	Vav1	3620	7409	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	IDO inhibits T-cell function through suppressing Vav1 expression and activation .
23344392	0	IDO1	41,45	indoleamine_2-3_dioxygenase	12,39	IDO1	indoleamine 2-3 dioxygenase	3620	3620	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of indoleamine_2-3_dioxygenase -LRB- IDO1 -RRB- expression in breast_cancer tissue by immunohistochemistry .
10571944	0	IDS	66,69	iduronate-2-sulfatase	43,64	IDS	iduronate-2-sulfatase	3423	3423	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel type of genetic rearrangement in the iduronate-2-sulfatase -LRB- IDS -RRB- gene involving deletion , duplications , and inversions .
11462244	0	IDS	122,125	iduronate-2-sulfatase	99,120	IDS	iduronate-2-sulfatase	3423	3423	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular analysis of 40 Italian patients with mucopolysaccharidosis_type_II : New mutations in the iduronate-2-sulfatase -LRB- IDS -RRB- gene .
7981716	0	IDS	40,43	iduronate-2-sulfatase	17,38	IDS	iduronate-2-sulfatase	3423	3423	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations of the iduronate-2-sulfatase -LRB- IDS -RRB- gene in patients with Hunter_syndrome -LRB- mucopolysaccharidosis_II -RRB- .
8530090	0	IDS	82,85	iduronate-2-sulfatase	59,80	IDS	iduronate-2-sulfatase	3423	3423	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of an alternative transcript from the human iduronate-2-sulfatase -LRB- IDS -RRB- gene .
9921913	0	IDS	50,53	iduronate-2-sulfatase	27,48	IDS	iduronate-2-sulfatase	3423	3423	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational spectrum of the iduronate-2-sulfatase -LRB- IDS -RRB- gene in 36 unrelated Russian MPS_II patients .
8244397	0	IDS	45,48	iduronate_2-sulfatase	22,43	IDS	iduronate 2-sulfatase	3423	3423	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence of the human iduronate_2-sulfatase -LRB- IDS -RRB- gene .
12509712	0	IDUA	115,119	alpha-L-iduronidase	94,113	IDUA	alpha-L-iduronidase	3425	3425	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Diversity of mutations and distribution of single nucleotide polymorphic alleles in the human alpha-L-iduronidase -LRB- IDUA -RRB- gene .
1362562	0	IDUA	65,69	alpha-L-iduronidase	44,63	IDUA	alpha-L-iduronidase	3425	3425	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	PCR detection of two RFLPs in exon I of the alpha-L-iduronidase -LRB- IDUA -RRB- gene .
9536518	0	IDUA	27,31	alpha-L-iduronidase	6,25	IDUA	alpha-L-iduronidase	3425	3425	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human alpha-L-iduronidase -LRB- IDUA -RRB- gene : correlation of polymorphic DNA haplotype and IDUA activity in Chinese population .
9700243	0	IDUA	27,31	alpha-L-iduronidase	6,25	IDUA	alpha-L-iduronidase	3425	3425	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human alpha-L-iduronidase -LRB- IDUA -RRB- gene : apparent recombination in intron 2 by haplotype analysis in a Taiwanese population .
9679043	0	IDX-1	52,57	Hoxa-4	65,71	IDX-1	Hoxa-4	18609(Tax:10090)	15401(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum .
9200067	0	IE	212,214	immediate_early	195,210	IE	immediate early	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Differences in resistance to herpes_simplex_virus_type_1 -LRB- HSV-1 -RRB- among oligodendroglia derived from different strains of mice are determined after viral adsorption but prior to the expression of immediate_early -LRB- IE -RRB- genes .
25621074	0	IER3	28,32	MiR-30a	0,7	IER3	MiR-30a	8870	407029	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	MiR-30a upregulates BCL2A1 , IER3 and cyclin_D2 expression by targeting FOXL2 .
17704804	0	IEX-1	92,97	NF-kappa_B	119,129	IEX-1	NF-kappa B	8870	4790	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	The apoptosis-inducing effect of gastrin on colorectal_cancer cells relates to an increased IEX-1 expression mediating NF-kappa_B inhibition .
16368886	0	IEX-1	25,30	Thrombopoietin	0,14	IEX-1	Thrombopoietin	8870	7066	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation .
16456541	0	IEX-1_and_ERK	91,104	ERK	36,39	IEX-1 and ERK	ERK	8870;5594	5594	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1_and_ERK .
235783	0	IF	54,56	intrinsic_factor	36,52	IF	intrinsic factor	2694	2694	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	The effect of duodenal juice on the intrinsic_factor -LRB- IF -RRB- activity in gastric juice .
25363454	0	IFI16	16,21	CD4	30,33	IFI16	CD4	3428	920	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Polymorphism in IFI16 affects CD4 -LRB- + -RRB- T-cell counts in HIV-1_infection .
26002845	0	IFI16	0,5	Flt-1	23,28	IFI16	Flt-1	3428	2321	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	IFI16 mediates soluble Flt-1 and endoglin production by trophoblast cells .
24970844	0	IFI16	58,63	IFNb	31,35	IFI16	IFNb	3428	3456	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Listeria_monocytogenes induces IFNb expression through an IFI16 - , cGAS - and STING-dependent pathway .
23027953	0	IFI16	8,13	IRF-3	27,32	IFI16	IRF-3	3428	3661	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein .
23027953	0	IFI16	91,96	IRF-3	27,32	IFI16	IRF-3	3428	3661	Gene	Gene	infection|nmod|START_ENTITY signaling|nmod|infection induction|acl|signaling induction|nmod|END_ENTITY	Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein .
19170058	0	IFI16	0,5	P53	57,60	IFI16	P53	3428	7157	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters .
19338980	0	IFI16	33,38	TNF-alpha	74,83	IFI16	TNF-alpha	3428	7124	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha .
24794504	0	IFI16	18,23	interferon-inducible_protein_16	25,56	IFI16	interferon-inducible protein 16	3428	3428	Gene	Gene	association|nmod|START_ENTITY association|dep|END_ENTITY	No association of IFI16 -LRB- interferon-inducible_protein_16 -RRB- variants with susceptibility to multiple_sclerosis .
12925527	0	IFI16	0,5	p53	51,54	IFI16	p53	3428	7157	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	IFI16 as a negative regulator in the regulation of p53 and p21 -LRB- Waf1 -RRB- .
14990579	0	IFI16	15,20	p53	51,54	IFI16	p53	3428	7157	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation .
15728246	0	IFI16	42,47	p53	82,85	IFI16	p53	3428	7157	Gene	Gene	gene|compound|START_ENTITY Up-regulation|nmod|gene triggers|nsubj|Up-regulation triggers|dobj|activity activity|compound|END_ENTITY	Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells .
17981542	0	IFI16	31,36	p53	121,124	IFI16	p53	3428	7157	Gene	Gene	Loss|nmod|START_ENTITY induces|nsubj|Loss induces|dobj|NBS1 NBS1|acl|leading leading|nmod|phosphorylation phosphorylation|nmod|SER37 SER37|compound|END_ENTITY	Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37 .
18974396	0	IFI16	57,62	p53	83,86	IFI16	p53	3428	7157	Gene	Gene	gene|appos|START_ENTITY Expression|nmod|gene up-regulated|nsubj|Expression up-regulated|nmod|END_ENTITY	Expression of an IFN-inducible cellular senescence gene , IFI16 , is up-regulated by p53 .
25544361	0	IFI16	51,56	p53	125,128	IFI16	p53	3428	7157	Gene	Gene	redistribution|nmod|START_ENTITY associated|nsubjpass|redistribution associated|nmod|activation activation|compound|END_ENTITY	Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular_carcinoma_cells in vitro is associated with p53 activation .
21454021	0	IFI6	55,59	interferon_alpha-inducible_protein_6	17,53	IFI6	interferon alpha-inducible protein 6	100909388	100909388	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation on interferon_alpha-inducible_protein_6 -LRB- IFI6 -RRB- gene as a candidate for meat and carcass quality in pig .
25337792	0	IFIH1	38,43	IRF5	45,49	IFIH1	IRF5	64135	3663	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|appos|END_ENTITY	Genetic Association Study of TNFAIP3 , IFIH1 , IRF5 Polymorphisms with Polymyositis/Dermatomyositis in Chinese Han Population .
16699517	0	IFIH1	125,130	interferon-induced_helicase	96,123	IFIH1	interferon-induced helicase	64135	64135	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	A genome-wide association study of nonsynonymous SNPs identifies a type_1_diabetes locus in the interferon-induced_helicase -LRB- IFIH1 -RRB- region .
25816333	0	IFIT5	107,112	Interferon-Induced_Protein_with_Tetratricopeptide_Repeats_5	46,105	IFIT5	Interferon-Induced Protein with Tetratricopeptide Repeats 5	101797569	101797569	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Identification and Expression Analysis of the Interferon-Induced_Protein_with_Tetratricopeptide_Repeats_5 -LRB- IFIT5 -RRB- Gene in Duck -LRB- Anas_platyrhynchos domesticus -RRB- .
19544527	0	IFITM2	21,27	1-8D	10,14	IFITM2	1-8D	10581	10581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human 1-8D gene -LRB- IFITM2 -RRB- is a novel p53 independent pro-apoptotic gene .
23354485	0	IFITM3	133,139	CD8	49,52	IFITM3	CD8	10410	925	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Enhanced survival of lung tissue-resident memory CD8 T cells during infection with influenza virus due to selective expression of IFITM3 .
19901966	0	IFITM3	81,87	OPN	96,99	IFITM3	OPN	361673(Tax:10116)	6696	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Interferon-induced transmembrane 3 binds osteopontin in vitro : expressed in vivo IFITM3 reduced OPN expression .
21600883	0	IFITM5	37,43	CD9	73,76	IFITM5	CD9	387733	928	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|association association|nmod|END_ENTITY	Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes .
17133498	0	IFN	74,77	IKKepsilon	19,29	IFN	IKKepsilon	3439	9641	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers .
25430775	0	IFN	36,39	IL-10	23,28	IFN	IL-10	3439	3586	Gene	Gene	role|parataxis|START_ENTITY role|nmod|END_ENTITY	The role of macrophage IL-10 / innate IFN interplay during virus-induced asthma .
15628995	0	IFN	32,35	interferon	20,30	IFN	interferon	3439	3439	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of the interferon -LRB- IFN -RRB- in the therapy .
23977359	0	IFN-a	0,5	Blimp-1	16,23	IFN-a	Blimp-1	3438	639	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IFN-a regulates Blimp-1 expression via miR-23a and miR-125b in both monocytes-derived DC and pDC .
20817881	0	IFN-a	58,63	C3a	11,14	IFN-a	C3a	111654(Tax:10090)	718	Gene	Gene	production|amod|START_ENTITY stimulate|dobj|production stimulate|nsubj|END_ENTITY	Complement C3a , CpG oligos , and DNA/C3a complex stimulate IFN-a production in a receptor for advanced glycation end product-dependent manner .
24813204	0	IFN-a	0,5	GATA3	17,22	IFN-a	GATA3	3438	2625	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	IFN-a suppresses GATA3 transcription from a distal exon and promotes H3K27 trimethylation of the CNS-1 enhancer in human Th2 cells .
20949125	0	IFN-a	76,81	IFN-y	57,62	IFN-a	IFN-y	3438	3458	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells signaling|compound|END_ENTITY	SH2 modified STAT1 induces HLA-I expression and improves IFN-y signaling in IFN-a resistant HCV replicon cells .
25541082	0	IFN-a	0,5	IL-10	14,19	IFN-a	IL-10	3439	3586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IFN-a induces IL-10 production and tilt the balance between Th1 and Th17 in Beh __ et_disease .
25304727	0	IFN-a	58,63	IL-2	33,37	IFN-a	IL-2	3440	3558	Gene	Gene	Interleukin-2|appos|START_ENTITY Interleukin-2|appos|END_ENTITY	Adjuvant Low-Dose Interleukin-2 -LRB- IL-2 -RRB- Plus Interferon-a -LRB- IFN-a -RRB- in Operable Renal_Cell_Carcinoma -LRB- RCC -RRB- : A Phase III , Randomized , Multicentre Trial of the Italian Oncology Group for Clinical Research -LRB- GOIRC -RRB- .
26519527	0	IFN-a	75,80	IRF5	57,61	IFN-a	IRF5	3438	3663	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-a Production in Women .
22022391	0	IFN-a	41,46	PCBP2	0,5	IFN-a	PCBP2	3440	5094	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	PCBP2 enhances the antiviral activity of IFN-a against HCV by stabilizing the mRNA of STAT1 and STAT2 .
23644631	0	IFN-a	10,15	STAT1	50,55	IFN-a	STAT1	111654(Tax:10090)	20846(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of IFN-a on KC and LIX expression : role of STAT1 and its effect on neutrophil recruitment to the spleen after lipopolysaccharide stimulation .
23935491	0	IFN-a	33,38	TLR7	9,13	IFN-a	TLR7	3438	51284	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Blocking TLR7 - and TLR9-mediated IFN-a production by plasmacytoid dendritic cells does not diminish immune activation in early SIV_infection .
22190517	0	IFN-a	25,30	miR-122	14,21	IFN-a	miR-122	3438	406906	Gene	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	-LSB- Influence of miR-122 on IFN-a treatment for HCV_infection -RSB- .
21263073	0	IFN-a	0,5	programmed_cell_death-1	24,47	IFN-a	programmed cell death-1	111654(Tax:10090)	18566(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|transcription transcription|amod|END_ENTITY	IFN-a directly promotes programmed_cell_death-1 transcription and limits the duration of T cell-mediated immunity .
10477584	0	IFN-alpha	12,21	CD95	74,78	IFN-alpha	CD95	3439	355	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Recombinant IFN-alpha -LRB- 2b -RRB- increases the expression of apoptosis receptor CD95 and chemokine receptors CCR1 and CCR3 in monocytoid cells .
16552819	0	IFN-alpha	98,107	ICAM-1	14,20	IFN-alpha	ICAM-1	3439	3383	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of ICAM-1 , HLA-DR , and CD80 on peripheral circulating CD1 alpha DCs induced in vivo by IFN-alpha in patients with chronic_hepatitis_B .
15699120	0	IFN-alpha	0,9	IFN-alpha	53,62	IFN-alpha	IFN-alpha	3439	3439	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	IFN-alpha regulates TLR-dependent gene expression of IFN-alpha , IFN-beta , IL-28 , and IL-29 .
15699120	0	IFN-alpha	53,62	IFN-alpha	0,9	IFN-alpha	IFN-alpha	3439	3439	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-alpha regulates TLR-dependent gene expression of IFN-alpha , IFN-beta , IL-28 , and IL-29 .
10454351	0	IFN-alpha	130,139	IFN-beta	107,115	IFN-alpha	IFN-beta	3439	3456	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the Jak-Stat pathway in cells that exhibit selective sensitivity to the antiviral effects of IFN-beta compared with IFN-alpha .
10656176	0	IFN-alpha	26,35	IFN-gamma	59,68	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Role of interferon alpha -LRB- IFN-alpha -RRB- and interferon gamma -LRB- IFN-gamma -RRB- in the control of the infection of monocyte-like cells with human_cytomegalovirus _ -LRB- HCMV -RRB- .
11449378	0	IFN-alpha	0,9	IFN-gamma	44,53	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	enhance|nsubj|START_ENTITY enhance|dobj|production production|amod|END_ENTITY	IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells : differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12 .
11449378	0	IFN-alpha	161,170	IFN-gamma	132,141	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells : differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12 .
11983129	0	IFN-alpha	147,156	IFN-gamma	20,29	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	-RSB-|amod|START_ENTITY produced|nmod|-RSB- produced|nsubj|Effect Effect|nmod|IL-12 IL-12|nmod|END_ENTITY	-LSB- Effect of IL-12 on IFN-gamma and IL-10 produced by peripheral blood mononuclear cells in patients with chronic hepatitis_B_virus infection during IFN-alpha treatment -RSB- .
1547881	0	IFN-alpha	99,108	IFN-gamma	122,131	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	combination|nmod|START_ENTITY alpha|nmod|combination END_ENTITY|amod|alpha	A prospective randomized comparison of single-agent interferon -LRB- IFN -RRB- - alpha with the combination of IFN-alpha and low-dose IFN-gamma in chronic_myelogenous_leukaemia .
17148690	0	IFN-alpha	42,51	IFN-gamma	24,33	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	therapy|amod|START_ENTITY axis|nmod|therapy axis|amod|END_ENTITY	Modulation of the IL-12 / IFN-gamma axis by IFN-alpha therapy for hepatitis_C .
1909084	0	IFN-alpha	48,57	IFN-gamma	129,138	IFN-alpha	IFN-gamma	111654(Tax:10090)	15978(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY Resistance|nmod|activity Resistance|dep|characterization characterization|nmod|effects effects|nmod|END_ENTITY	Resistance to the antiproliferative activity of IFN-alpha : further characterization and demonstration of antagonistic effects of IFN-gamma .
8266815	0	IFN-alpha	28,37	IFN-gamma	100,109	IFN-alpha	IFN-gamma	111654(Tax:10090)	15978(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY resistance|nmod|activity Prevention|nmod|resistance Prevention|dep|characterization characterization|nmod|effect effect|nmod|END_ENTITY	Prevention of resistance to IFN-alpha antiproliferative activity : characterization of the effect of IFN-gamma and substitution for IFN-gamma by tumor_necrosis_factor .
8807500	0	IFN-alpha	33,42	IFN-gamma	0,9	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IFN-gamma enhances production of IFN-alpha in human macrophages but not in monocytes .
8829490	0	IFN-alpha	128,137	IFN-gamma	158,167	IFN-alpha	IFN-gamma	3439	3458	Gene	Gene	2b|amod|START_ENTITY 2b|nmod|failure failure|nmod|END_ENTITY	B-cell_chronic_lymphocytic_leukemia associated with high serum IGE levels and pruriginous_skin_lesions : successful therapy with IFN-alpha 2b after failure on IFN-gamma .
9475662	0	IFN-alpha	20,29	IFN-gamma	108,117	IFN-alpha	IFN-gamma	111654(Tax:10090)	15978(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Orally administered IFN-alpha acts alone and in synergistic combination with intraperitoneally administered IFN-gamma to exert an antitumor effect against B16_melanoma in mice .
9661265	0	IFN-alpha	39,48	IFN-gamma	50,59	IFN-alpha	IFN-gamma	100310804(Tax:9823)	396991(Tax:9823)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|TNF-alpha TNF-alpha|compound|END_ENTITY	Evaluation of various cytokines -LRB- IL-6 , IFN-alpha , IFN-gamma , TNF-alpha -RRB- as markers for acute bacterial_infection in swine -- a possible role for serum interleukin-6 .
12682235	0	IFN-alpha	117,126	IFN-gamma-inducible_protein-10	23,53	IFN-alpha	IFN-gamma-inducible protein-10	3439	3627	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|compound|END_ENTITY	CpG-A-induced monocyte IFN-gamma-inducible_protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha .
14581002	0	IFN-alpha	0,9	IFN_regulatory_factor_1	29,52	IFN-alpha	IFN regulatory factor 1	3439	3659	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	IFN-alpha and IL-12 activate IFN_regulatory_factor_1 -LRB- IRF-1 -RRB- , IRF-4 , and IRF-8 gene expression in human NK and T cells .
1436241	0	IFN-alpha	10,19	IL-1-alpha	32,42	IFN-alpha	IL-1-alpha	3439	3552	Gene	Gene	START_ENTITY|dep|TNF-alpha TNF-alpha|compound|END_ENTITY	Cytokine -LRB- IFN-alpha , IFN-gamma , IL-1-alpha , TNF-alpha -RRB- - induced modulation of HLA cell surface expression in human breast_cancer cell lines .
8569177	0	IFN-alpha	131,140	IL-10	124,129	IFN-alpha	IL-10	111654(Tax:10090)	16153(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
10925275	0	IFN-alpha	0,9	IL-18	27,32	IFN-alpha	IL-18	3439	3606	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells .
11567773	0	IFN-alpha	49,58	IL-1beta	20,28	IFN-alpha	IL-1beta	396398(Tax:9031)	395196(Tax:9031)	Gene	Gene	TGF-beta4|amod|START_ENTITY TGF-beta4|compound|END_ENTITY	Adjuvant effects of IL-1beta , IL-2 , IL-8 , IL-15 , IFN-alpha , IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina .
10679063	0	IFN-alpha	0,9	IL-2	21,25	IFN-alpha	IL-2	3439	3558	Gene	Gene	2b|amod|START_ENTITY reduces|nsubj|2b reduces|dobj|production production|compound|END_ENTITY	IFN-alpha 2b reduces IL-2 production and IL-2_receptor function in primary CD4 + T cells .
15622622	0	IFN-alpha	12,21	IL-2	70,74	IFN-alpha	IL-2	3439	3558	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	-LSB- Effects of IFN-alpha on the expressions of perforin and granzymes in IL-2 activated lymphocytes -RSB- .
1987429	0	IFN-alpha	21,30	IL-2	41,45	IFN-alpha	IL-2	111654(Tax:10090)	16183(Tax:10090)	Gene	Gene	survival|nmod|START_ENTITY augmented|nsubj|survival augmented|dobj|therapy therapy|compound|END_ENTITY	Enhanced survival of IFN-alpha augmented IL-2 therapy of pulmonary metastases : efficacy comparable to interleukin-2 and lymphokine activated killer cells .
7919965	0	IFN-alpha	91,100	IL-2	121,125	IFN-alpha	IL-2	3439	3558	Gene	Gene	interferon-alpha|appos|START_ENTITY interferon-alpha|appos|END_ENTITY	HLA class I alleles and responsiveness of melanoma to immunotherapy with interferon-alpha -LRB- IFN-alpha -RRB- and interleukin-2 -LRB- IL-2 -RRB- .
8569177	0	IFN-alpha	131,140	IL-2	106,110	IFN-alpha	IL-2	111654(Tax:10090)	16183(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|compound|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8899186	0	IFN-alpha	92,101	IL-2	87,91	IFN-alpha	IL-2	3439	3558	Gene	Gene	lymphocytes|amod|START_ENTITY lymphocytes|dep|Soluble Soluble|dobj|receptors receptors|nmod|patients patients|acl|receiving receiving|nmod|END_ENTITY	Soluble IL-6 receptors -LRB- sIL-6R -RRB- in hematological patients receiving immunotherapy with IL-2 / IFN-alpha or donor lymphocytes following bone marrow transplantation .
15178704	0	IFN-alpha	0,9	IL-21	20,25	IFN-alpha	IL-21	3439	59067	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells .
17684041	0	IFN-alpha	0,9	IL-27	48,53	IFN-alpha	IL-27	3439	246778	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages .
8569177	0	IFN-alpha	131,140	IL-4	112,116	IFN-alpha	IL-4	111654(Tax:10090)	16189(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
10576377	0	IFN-alpha	89,98	IL-6	42,46	IFN-alpha	IL-6	3439	3569	Gene	Gene	therapy|amod|START_ENTITY efficacy|nmod|therapy predict|dobj|efficacy predict|nsubj|analysis analysis|nmod|production production|nmod|END_ENTITY	Two-dimensional analysis of production of IL-6 and TNF-alpha can predict the efficacy of IFN-alpha therapy .
11877000	0	IFN-alpha	12,21	IL-6	36,40	IFN-alpha	IL-6	3439	3569	Gene	Gene	START_ENTITY|acl|combined combined|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of IFN-alpha combined with IL-6 on cell growth and related genes expression and apoptosis of bone marrow cells from CGL patients -RSB- .
1753108	0	IFN-alpha	0,9	IL-6	42,46	IFN-alpha	IL-6	3439	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	IFN-alpha induces autocrine production of IL-6 in myeloma cell lines .
19615438	0	IFN-alpha	35,44	IL-6	68,72	IFN-alpha	IL-6	3439	3569	Gene	Gene	treatment|amod|START_ENTITY depression|nmod|treatment depression|dep|role role|nmod|END_ENTITY	Cytokine-induced depression during IFN-alpha treatment : the role of IL-6 and sleep_quality .
8899186	0	IFN-alpha	92,101	IL-6	8,12	IFN-alpha	IL-6	3439	3569	Gene	Gene	lymphocytes|amod|START_ENTITY lymphocytes|dep|Soluble Soluble|dobj|receptors receptors|compound|END_ENTITY	Soluble IL-6 receptors -LRB- sIL-6R -RRB- in hematological patients receiving immunotherapy with IL-2 / IFN-alpha or donor lymphocytes following bone marrow transplantation .
8569177	0	IFN-alpha	131,140	IL-7	118,122	IFN-alpha	IL-7	111654(Tax:10090)	16196(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
10550547	0	IFN-alpha	0,9	IL_10	20,25	IFN-alpha	IL 10	3439	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	IFN-alpha regulates IL_10 production by CML cells in vitro .
10213463	0	IFN-alpha	160,169	MxA	48,51	IFN-alpha	MxA	3440	4599	Gene	Gene	chronic_active_hepatitis_C|nmod|START_ENTITY therapy|amod|chronic_active_hepatitis_C patients|nmod|therapy response|nmod|patients Correlation|nmod|response Correlation|nmod|mRNA mRNA|compound|END_ENTITY	Correlation of interferon-induced expression of MxA mRNA in peripheral blood mononuclear cells with the response of patients with chronic_active_hepatitis_C to IFN-alpha therapy .
17892402	0	IFN-alpha	93,102	MxA	0,3	IFN-alpha	MxA	3440	4599	Gene	Gene	treatment|amod|START_ENTITY predict|nmod|treatment predict|nsubj|induction induction|compound|END_ENTITY	MxA induction may predict sustained virologic responses of chronic_hepatitis_B patients with IFN-alpha treatment .
7540146	0	IFN-alpha	0,9	MxA	18,21	IFN-alpha	MxA	3439	4599	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IFN-alpha induces MxA gene expression in cultured human corneal fibroblasts .
9348307	0	IFN-alpha	229,238	NOS2	189,193	IFN-alpha	NOS2	3439	4843	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Interferon _ -LRB- IFN -RRB- - alpha activation of human blood mononuclear cells in vitro and in vivo for nitric_oxide_synthase -LRB- NOS -RRB- type 2 mRNA and protein expression : possible relationship of induced NOS2 to the anti-hepatitis_C effects of IFN-alpha in vivo .
16810633	0	IFN-alpha	44,53	RelB	36,40	IFN-alpha	RelB	3439	5971	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming .
10490982	0	IFN-alpha	0,9	Stat6	20,25	IFN-alpha	Stat6	3439	6778	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	IFN-alpha activates Stat6 and leads to the formation of Stat2 : Stat6 complexes in B cells .
10490982	0	IFN-alpha	0,9	Stat6	62,67	IFN-alpha	Stat6	3439	6778	Gene	Gene	activates|nsubj|START_ENTITY activates|parataxis|complexes complexes|amod|END_ENTITY	IFN-alpha activates Stat6 and leads to the formation of Stat2 : Stat6 complexes in B cells .
15990796	0	IFN-alpha	24,33	TH2	63,66	IFN-alpha	TH2	3439	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Differential effects of IFN-alpha on the expression of various TH2 cytokines in human CD4 + T cells .
19124725	0	IFN-alpha	20,29	TLR4	0,4	IFN-alpha	TLR4	111654(Tax:10090)	21898(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induce|dobj|production ligands|xcomp|induce ligands|nsubj|END_ENTITY	TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming .
15723075	0	IFN-alpha	38,47	TLR7	113,117	IFN-alpha	TLR7	111654(Tax:10090)	170743(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY Sequence-specific|dobj|induction Sequence-specific|advcl|interfering interfering|nmod|END_ENTITY	Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7 .
16887967	0	IFN-alpha	27,36	TLR7	0,4	IFN-alpha	TLR7	3439	51284	Gene	Gene	production|amod|START_ENTITY induce|dobj|production ligands|xcomp|induce ligands|nsubj|END_ENTITY	TLR7 ligands induce higher IFN-alpha production in females .
17565046	0	IFN-alpha	37,46	TLR7	88,92	IFN-alpha	TLR7	3439	51284	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule , synthetic TLR7 ligand .
15470074	0	IFN-alpha	141,150	TLR9	119,123	IFN-alpha	TLR9	111654(Tax:10090)	81897(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black -LRB- NZB -RRB- mice : high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow .
12091360	0	IFN-alpha	27,36	TNF-alpha	87,96	IFN-alpha	TNF-alpha	3439	7124	Gene	Gene	cells|nmod|START_ENTITY Response|nmod|cells involves|nsubj|Response involves|dobj|induction induction|nmod|apoptosis apoptosis|nmod|END_ENTITY	Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion .
16542137	0	IFN-alpha	16,25	TNF-alpha	36,45	IFN-alpha	TNF-alpha	3439	7124	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	Ingested -LRB- oral -RRB- IFN-alpha represses TNF-alpha mRNA in relapsing-remitting_multiple_sclerosis .
17786371	0	IFN-alpha	0,9	TNF-alpha	24,33	IFN-alpha	TNF-alpha	3439	7124	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	IFN-alpha competes with TNF-alpha for STAT-1alpha ; molecular basis for immune escape of human colon_adenocarcinoma COLO 205 cells .
8680797	0	IFN-alpha	68,77	TNF-alpha	22,31	IFN-alpha	TNF-alpha	111654(Tax:10090)	21926(Tax:10090)	Gene	Gene	FdUMP|nmod|START_ENTITY production|nmod|FdUMP Suppressive|nmod|production Suppressive|dobj|effect effect|nmod|END_ENTITY	Suppressive effect of TNF-alpha on increased production of FdUMP by IFN-alpha .
9661265	0	IFN-alpha	39,48	TNF-alpha	61,70	IFN-alpha	TNF-alpha	100310804(Tax:9823)	397086(Tax:9823)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Evaluation of various cytokines -LRB- IL-6 , IFN-alpha , IFN-gamma , TNF-alpha -RRB- as markers for acute bacterial_infection in swine -- a possible role for serum interleukin-6 .
12817000	0	IFN-alpha	36,45	TNF-related_apoptosis-inducing_ligand	54,91	IFN-alpha	TNF-related apoptosis-inducing ligand	3439	8743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Plasmacytoid dendritic cell-derived IFN-alpha induces TNF-related_apoptosis-inducing_ligand / Apo-2L-mediated antitumor activity by human monocytes following CpG oligodeoxynucleotide stimulation .
12097384	0	IFN-alpha	144,153	TRAIL	66,71	IFN-alpha	TRAIL	3439	8743	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Tumor-infiltrating CD4 + T lymphocytes express APO2_ligand -LRB- APO2L -RRB- / TRAIL upon specific stimulation with autologous lung_carcinoma cells : role of IFN-alpha on APO2L/TRAIL expression and - mediated cytotoxicity .
17992200	0	IFN-alpha	62,71	TRAIL	138,143	IFN-alpha	TRAIL	3439	8743	Gene	Gene	armed|nmod|START_ENTITY vector|acl|armed activity|nmod|vector enhanced|nsubjpass|activity enhanced|nmod|expression expression|nmod|END_ENTITY	Anticancer activity of oncolytic adenovirus vector armed with IFN-alpha and ADP is enhanced by pharmacologically controlled expression of TRAIL .
9469437	0	IFN-alpha	66,75	hIFNAR1	86,93	IFN-alpha	hIFNAR1	3439	3454	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Structure-function study of the extracellular domain of the human IFN-alpha receptor -LRB- hIFNAR1 -RRB- using blocking monoclonal antibodies : the role of domains 1 and 2 .
9368190	0	IFN-alpha	37,46	interferon_consensus_sequence_binding_protein	68,113	IFN-alpha	interferon consensus sequence binding protein	111654(Tax:10090)	15900(Tax:10090)	Gene	Gene	START_ENTITY|nmod|messenger messenger|compound|END_ENTITY	Analysis of the antagonist effect of IFN-alpha on IFN-gamma-induced interferon_consensus_sequence_binding_protein messenger RNA in murine macrophages .
18937499	0	IFN-alpha2	55,65	IFNAR-1	16,23	IFN-alpha2	IFNAR-1	3440	3454	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists .
24048896	0	IFN-b	34,39	Annexin-A1	0,10	IFN-b	Annexin-A1	15977(Tax:10090)	16952(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Annexin-A1 regulates TLR-mediated IFN-b production through an interaction with TANK-binding_kinase_1 .
25664835	0	IFN-b	104,109	IFN-b	40,45	IFN-b	IFN-b	3456	3456	Gene	Gene	Downstream|compound|START_ENTITY Driver|nmod|Downstream TRK_Fused_Gene|appos|Driver Production|nmod|TRK_Fused_Gene Production|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	IFN-b	40,45	IFN-b	104,109	IFN-b	IFN-b	3456	3456	Gene	Gene	Production|compound|START_ENTITY Production|nmod|TRK_Fused_Gene TRK_Fused_Gene|appos|Driver Driver|nmod|Downstream Downstream|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
26059829	0	IFN-b	24,29	IL-23	40,45	IFN-b	IL-23	15977(Tax:10090)	83430(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of IFN-b on IL-12 , IL-23 , and IL-10 expression in TLR-stimulated dendritic cells .
23119059	0	IFN-b	0,5	IL-9	43,47	IFN-b	IL-9	15977(Tax:10090)	16198(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	IFN-b inhibits the increased expression of IL-9 during experimental autoimmune uveoretinitis .
21217011	0	IFN-b	28,33	NF-kB1	0,6	IFN-b	NF-kB1	15977(Tax:10090)	18033(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	NF-kB1 inhibits TLR-induced IFN-b production in macrophages through TPL-2-dependent ERK activation .
22745372	0	IFN-b	29,34	NP1	16,19	IFN-b	NP1	3456	4884	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Human_bocavirus NP1 inhibits IFN-b production by blocking association of IFN regulatory factor 3 with IFNB promoter .
22427889	0	IFN-b	27,32	Nfkb1	0,5	IFN-b	Nfkb1	15977(Tax:10090)	18033(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Nfkb1 inhibits LPS-induced IFN-b and IL-12_p40 production in macrophages by distinct mechanisms .
23707530	0	IFN-b	77,82	RIG-I	62,67	IFN-b	RIG-I	3456	23586	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Inducible_cAMP_early_repressor -LRB- ICER -RRB- is a novel regulator of RIG-I mediated IFN-b production .
24439904	0	IFN-b	42,47	Sema4A	0,6	IFN-b	Sema4A	3456	64218	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Sema4A inhibits the therapeutic effect of IFN-b in EAE .
22945920	0	IFN-b	53,58	TANK-binding_kinase_1	133,154	IFN-b	TANK-binding kinase 1	3456	29110	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|advcl|promoting promoting|dobj|degradation degradation|nmod|END_ENTITY	TRAF-interacting_protein -LRB- TRIP -RRB- negatively regulates IFN-b production and antiviral response by promoting proteasomal degradation of TANK-binding_kinase_1 .
24043902	0	IFN-b	19,24	TANK-binding_kinase_1	77,98	IFN-b	TANK-binding kinase 1	15977(Tax:10090)	56480(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	Lithium attenuates IFN-b production and antiviral response via inhibition of TANK-binding_kinase_1 kinase activity .
24048896	0	IFN-b	34,39	TANK-binding_kinase_1	79,100	IFN-b	TANK-binding kinase 1	15977(Tax:10090)	56480(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nmod|interaction interaction|nmod|END_ENTITY	Annexin-A1 regulates TLR-mediated IFN-b production through an interaction with TANK-binding_kinase_1 .
25070846	0	IFN-b	52,57	TANK-binding_kinase_1	105,126	IFN-b	TANK-binding kinase 1	3456	29110	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Ubiquitin-specific protease 2b negatively regulates IFN-b production and antiviral activity by targeting TANK-binding_kinase_1 .
22945920	0	IFN-b	53,58	TRAF-interacting_protein	0,24	IFN-b	TRAF-interacting protein	3456	10293	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	TRAF-interacting_protein -LRB- TRIP -RRB- negatively regulates IFN-b production and antiviral response by promoting proteasomal degradation of TANK-binding_kinase_1 .
23056470	0	IFN-b	42,47	TRIM38	0,6	IFN-b	TRIM38	3456	10475	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TRIM38 negatively regulates TLR3-mediated IFN-b signaling by targeting TRIF for degradation .
24999993	0	IFN-b	28,33	TRIM68	0,6	IFN-b	TRIM68	3456	55128	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	TRIM68 negatively regulates IFN-b production by degrading TRK fused gene , a novel driver of IFN-b downstream of anti-viral detection systems .
24999993	0	IFN-b	92,97	TRIM68	0,6	IFN-b	TRIM68	3456	55128	Gene	Gene	downstream|compound|START_ENTITY driver|nmod|downstream gene|appos|driver fused|nsubj|gene fused|dep|regulates regulates|nsubj|END_ENTITY	TRIM68 negatively regulates IFN-b production by degrading TRK fused gene , a novel driver of IFN-b downstream of anti-viral detection systems .
25664835	0	IFN-b	104,109	TRIM68	12,18	IFN-b	TRIM68	3456	55128	Gene	Gene	Downstream|compound|START_ENTITY Driver|nmod|Downstream TRK_Fused_Gene|appos|Driver Production|nmod|TRK_Fused_Gene Production|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	IFN-b	40,45	TRIM68	12,18	IFN-b	TRIM68	3456	55128	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	IFN-b	104,109	TRK_Fused_Gene	70,84	IFN-b	TRK Fused Gene	3456	10342	Gene	Gene	Downstream|compound|START_ENTITY Driver|nmod|Downstream END_ENTITY|appos|Driver	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	IFN-b	40,45	TRK_Fused_Gene	70,84	IFN-b	TRK Fused Gene	3456	10342	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25712217	0	IFN-b	43,48	US1	30,33	IFN-b	US1	3456	1487350(Tax:10310)	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	HSV-2 immediate-early protein US1 inhibits IFN-b production by suppressing association of IRF-3 with IFN-b promoter .
24936223	0	IFN-b	0,5	neurotrophic_factor	13,32	IFN-b	neurotrophic factor	3456	4908	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	IFN-b alters neurotrophic_factor expression in T cells isolated from multiple_sclerosis patients - implication of novel neurotensin/NTSR1 pathway in neuroprotection .
15119740	0	IFN-beta	20,28	CCL2	43,47	IFN-beta	CCL2	3456	6347	Gene	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Long-term effect of IFN-beta 1a therapy on CCL2 -LRB- MCP-1 -RRB- chemokine in patients with multiple_sclerosis .
18811584	0	IFN-beta	161,169	CCL27	111,116	IFN-beta	CCL27	3456	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IFN-beta	161,169	CCR4	125,129	IFN-beta	CCR4	3456	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IFN-beta	161,169	CCR5	131,135	IFN-beta	CCR5	3456	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
10601848	0	IFN-beta	63,71	CD14	38,42	IFN-beta	CD14	15977(Tax:10090)	12475(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Important role of membrane-associated CD14 in the induction of IFN-beta and subsequent nitric_oxide production by murine macrophages in response to bacterial lipopolysaccharide .
17911479	0	IFN-beta	23,31	CD73	95,99	IFN-beta	CD73	3456	4907	Gene	Gene	action|nmod|START_ENTITY Mechanism|nmod|action Mechanism|dep|reference reference|nmod|END_ENTITY	Mechanism of action of IFN-beta in the treatment of multiple_sclerosis : a special reference to CD73 and adenosine .
18034430	0	IFN-beta	0,8	CD73	61,65	IFN-beta	CD73	15977(Tax:10090)	23959(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|leakage leakage|nmod|up-regulation up-regulation|nmod|END_ENTITY	IFN-beta protects from vascular leakage via up-regulation of CD73 .
18825744	0	IFN-beta	0,8	CD73	19,23	IFN-beta	CD73	3456	4907	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier .
18811584	0	IFN-beta	161,169	CXCR3	137,142	IFN-beta	CXCR3	3456	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
9686625	0	IFN-beta	23,31	Fc_gamma_receptor	63,80	IFN-beta	Fc gamma receptor	3456	2209	Gene	Gene	action|nmod|START_ENTITY action|nmod|expression expression|compound|END_ENTITY	Antagonistic action of IFN-beta and IFN-gamma on high affinity Fc_gamma_receptor expression in healthy controls and multiple_sclerosis patients .
18981097	0	IFN-beta	0,8	GSK3-beta	86,95	IFN-beta	GSK3-beta	15977(Tax:10090)	56637(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	IFN-beta production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-beta .
10454351	0	IFN-beta	107,115	IFN-alpha	130,139	IFN-beta	IFN-alpha	3456	3439	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the Jak-Stat pathway in cells that exhibit selective sensitivity to the antiviral effects of IFN-beta compared with IFN-alpha .
14980076	0	IFN-beta	19,27	IFNAR-2	80,87	IFN-beta	IFNAR-2	3456	3455	Gene	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Formation of human IFN-beta complex with the soluble type I interferon receptor IFNAR-2 leads to enhanced IFN stability , pharmacokinetics , and antitumor activity in xenografted SCID mice .
11080475	0	IFN-beta	43,51	IL-4	66,70	IFN-beta	IL-4	15977(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Inhibition of the constitutive and induced IFN-beta production by IL-4 and IL-10 in murine peritoneal macrophages .
18811584	0	IFN-beta	161,169	IP-10	118,123	IFN-beta	IP-10	3456	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
1886766	0	IFN-beta	14,22	IRF-1	34,39	IFN-beta	IRF-1	3456	3659	Gene	Gene	element|amod|START_ENTITY element|nmod|END_ENTITY	Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis .
7843405	0	IFN-beta	96,104	ISGF3_gamma	49,60	IFN-beta	ISGF3 gamma	15977(Tax:10090)	16391(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene END_ENTITY|nmod|expression	Possible involvement of the transcription factor ISGF3_gamma in virus-induced expression of the IFN-beta gene .
16797728	0	IFN-beta	11,19	LIF	47,50	IFN-beta	LIF	3456	3976	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of IFN-beta , leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls .
16140920	0	IFN-beta	0,8	MGMT	58,62	IFN-beta	MGMT	3456	4255	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide .
18811584	0	IFN-beta	161,169	MIP-1alpha	99,109	IFN-beta	MIP-1alpha	3456	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IFN-beta	161,169	PD1	144,147	IFN-beta	PD1	3456	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IFN-beta	161,169	PDL2	149,153	IFN-beta	PDL2	3456	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
21321205	0	IFN-beta	154,162	TLR8	104,108	IFN-beta	TLR8	3456	51311	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Phagosomal signaling by Borrelia_burgdorferi in human monocytes involves Toll-like receptor -LRB- TLR -RRB- 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta .
18412159	0	IFN-beta	89,97	X-box_binding_protein_1	112,135	IFN-beta	X-box binding protein 1	3456	7494	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box_binding_protein_1 .
19201901	0	IFN-beta	77,85	high_mobility_group_box_1	43,68	IFN-beta	high mobility group box 1	15977(Tax:10090)	15289(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Bacterial endotoxin induces the release of high_mobility_group_box_1 via the IFN-beta signaling pathway .
19670379	0	IFN-beta	22,30	osteopontin	48,59	IFN-beta	osteopontin	15977(Tax:10090)	20750(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4 + T Cells in MS. IFN-beta currently serves as one of the major treatments for MS. Its anti-inflammatory mechanism has been reported as involving a shift in cytokine balance from Th1 to Th2 in the T-cell response against elements of the myelin sheath .
9452363	0	IFN-beta	39,47	p21ras	29,35	IFN-beta	p21ras	3456	3265	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Dose-dependent activation of p21ras by IFN-beta .
2461199	0	IFN-beta_2	173,183	BSF-2	184,189	IFN-beta 2	BSF-2	3569	3569	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Inhibitory effect of human recombinant interferon gamma on synthesis of acute phase proteins in human hepatoma Hep G2 cells stimulated by leukocyte cytokines , TNF_alpha and IFN-beta_2 / BSF-2 / IL-6 .
2836512	1	IFN-beta_2	87,97	B_cell_stimulatory_factor_2	98,125	IFN-beta 2	B cell stimulatory factor 2	3569	3569	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|END_ENTITY	Role of IFN-beta_2 / B_cell_stimulatory_factor_2 / IL-6 .
2651521	0	IFN-beta_2	31,41	IL-6	42,46	IFN-beta 2	IL-6	3569	3569	Gene	Gene	production|nmod|START_ENTITY production|dep|END_ENTITY	Cytokine-induced production of IFN-beta_2 / IL-6 by freshly explanted human endometrial stromal cells .
17878351	0	IFN-epsilon	0,11	STAT1	39,44	IFN-epsilon	STAT1	338376	6772	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	IFN-epsilon mediates TNF-alpha-induced STAT1 phosphorylation and induction of retinoic_acid-inducible gene-I in human cervical_cancer cells .
10092821	0	IFN-gamma	0,9	A2B	27,30	IFN-gamma	A2B	15978(Tax:10090)	11541(Tax:10090)	Gene	Gene	up-regulates|amod|START_ENTITY up-regulates|dep|expression expression|compound|END_ENTITY	IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages : a mechanism of macrophage deactivation .
18789440	0	IFN-gamma	0,9	ABCA1	25,30	IFN-gamma	ABCA1	3458	19	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner .
9688322	0	IFN-gamma	0,9	AP-1	19,23	IFN-gamma	AP-1	3458	3726	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	IFN-gamma inhibits AP-1 binding activity in human brain-derived cells through a nitric_oxide dependent mechanism .
16085391	0	IFN-gamma	0,9	B7-H1	38,43	IFN-gamma	B7-H1	3458	29126	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	IFN-gamma regulates the expression of B7-H1 in dermal fibroblast cells .
17374731	0	IFN-gamma	16,25	BRCA1	0,5	IFN-gamma	BRCA1	3458	672	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BRCA1 regulates IFN-gamma signaling through a mechanism involving the type I IFNs .
14636443	0	IFN-gamma	82,91	Bcl-2	15,20	IFN-gamma	Bcl-2	25712(Tax:10116)	24224(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY Expression|nmod|-RSB- Expression|nmod|proteins proteins|amod|END_ENTITY	-LSB- Expression of Bcl-2 and Bax proteins in rat liver fibrosis model and the role of IFN-gamma -RSB- .
18279102	0	IFN-gamma	0,9	Bcl-2	61,66	IFN-gamma	Bcl-2	3458	596	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	IFN-gamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression .
9472684	0	IFN-gamma	119,128	Bcl-2	165,170	IFN-gamma	Bcl-2	3458	596	Gene	Gene	interferon-gamma|dep|START_ENTITY Apoptosis|amod|interferon-gamma Apoptosis|nmod|expression expression|compound|END_ENTITY	Apoptosis of colorectal_adenocarcinoma -LRB- COLO 201 -RRB- by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and/or interferon-gamma -LRB- IFN-gamma -RRB- , resulting from down-modulation of Bcl-2 expression .
19171874	0	IFN-gamma	13,22	C1q	0,3	IFN-gamma	C1q	3458	712	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells .
8955209	0	IFN-gamma	63,72	C3a	31,34	IFN-gamma	C3a	3458	718	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of the C3a and C5a_receptors -LRB- CD88 -RRB- by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines .
11359851	0	IFN-gamma	134,143	CCR4	19,23	IFN-gamma	CCR4	3458	1233	Gene	Gene	ratios|amod|START_ENTITY subset|dep|ratios defines|dobj|subset defines|nsubj|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
16804321	0	IFN-gamma	85,94	CCR4	80,84	IFN-gamma	CCR4	3458	1233	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Delayed allergic_reaction to suxamethonium driven by oligoclonal Th1-skewed CD4 + CCR4 + IFN-gamma + memory T cells .
19654865	0	IFN-gamma	41,50	CCR4	52,56	IFN-gamma	CCR4	3458	1233	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
1311348	0	IFN-gamma	0,9	CD16	47,51	IFN-gamma	CD16	3458	2214	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|Fc_gamma_RIII Fc_gamma_RIII|appos|END_ENTITY	IFN-gamma induces expression of Fc_gamma_RIII -LRB- CD16 -RRB- on human eosinophils .
21187373	0	IFN-gamma	127,136	CD16	81,85	IFN-gamma	CD16	3458	2214	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Revisiting human natural killer cell subset function revealed cytolytic CD56 -LRB- dim -RRB- CD16 + NK cells as rapid producers of abundant IFN-gamma on activation .
11745365	0	IFN-gamma	22,31	CD19	0,4	IFN-gamma	CD19	15978(Tax:10090)	12478(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	CD19 -LRB- + -RRB- cells produce IFN-gamma in mice infected with Borrelia_burgdorferi .
11034419	0	IFN-gamma	72,81	CD1d	18,22	IFN-gamma	CD1d	3458	912	Gene	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of CD1d by keratinocytes in psoriasis and CD1d-dependent IFN-gamma production by NK-T cells .
15611472	0	IFN-gamma	50,59	CD25	26,30	IFN-gamma	CD25	15978(Tax:10090)	16184(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY cells|nmod|mice END_ENTITY|nmod|cells	Impaired up-regulation of CD25 on CD4 + T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart_failure .
15743488	0	IFN-gamma	150,159	CD25	14,18	IFN-gamma	CD25	15978(Tax:10090)	16184(Tax:10090)	Gene	Gene	counter-regulated|nmod|START_ENTITY pathogenesis|acl|counter-regulated factor|nmod|pathogenesis functioning|dep|factor functioning|compound|END_ENTITY	Defective CD4 + CD25 + regulatory T cell functioning in collagen-induced_arthritis : an important factor in pathogenesis , counter-regulated by endogenous IFN-gamma .
15935883	0	IFN-gamma	40,49	CD25	106,110	IFN-gamma	CD25	3458	3559	Gene	Gene	production|amod|START_ENTITY controls|dobj|production controls|advcl|regulating regulating|dobj|effect effect|nmod|cells cells|compound|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
16177085	0	IFN-gamma	0,9	CD25	53,57	IFN-gamma	CD25	15978(Tax:10090)	16184(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|generation/activation generation/activation|nmod|cells cells|compound|END_ENTITY	IFN-gamma controls the generation/activation of CD4 + CD25 + regulatory T cells in antitumor immune response .
16906223	0	IFN-gamma	8,17	CD25	63,67	IFN-gamma	CD25	15978(Tax:10090)	16184(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
17851131	0	IFN-gamma	85,94	CD25	29,33	IFN-gamma	CD25	3458	3669	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells inhibit|dobj|induction inhibit|nsubj|frequency frequency|nmod|END_ENTITY	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
18298587	0	IFN-gamma	67,76	CD25	62,66	IFN-gamma	CD25	3458	3669	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Observational support for an immunoregulatory role of CD3 + CD4 + CD25 + IFN-gamma + blood lymphocytes in kidney transplant recipients with good long-term graft outcome .
18388182	0	IFN-gamma	73,82	CD25	5,9	IFN-gamma	CD25	3458	3669	Gene	Gene	produce|dobj|START_ENTITY inhibit|advcl|produce inhibit|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6 .
19654865	0	IFN-gamma	41,50	CD25	63,67	IFN-gamma	CD25	3458	3559	Gene	Gene	CD4|compound|START_ENTITY levels|nmod|CD4 +|nsubj|levels +|dobj|cells cells|nummod|END_ENTITY	Abnormally high levels of virus-infected IFN-gamma + CCR4 + CD4 + CD25 + T cells in a retrovirus-associated neuroinflammatory_disorder .
19853929	0	IFN-gamma	86,95	CD25	31,35	IFN-gamma	CD25	3458	3559	Gene	Gene	cells|dep|START_ENTITY CD25|nmod|cells T|nmod|CD25 T|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19853929	0	IFN-gamma	86,95	CD25	56,60	IFN-gamma	CD25	3458	3559	Gene	Gene	cells|dep|START_ENTITY END_ENTITY|nmod|cells	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
1682383	1	IFN-gamma	105,114	CD3	66,69	IFN-gamma	CD3	15978(Tax:10090)	12501(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|+ +|compound|END_ENTITY	Murine CD3 + , gamma/delta TCR + T cells produce IFN-gamma and IL-5 .
10047431	0	IFN-gamma	46,55	CD4	5,8	IFN-gamma	CD4	25712(Tax:10116)	24932(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY required|nmod|expression T|ccomp|required T|nsubj|END_ENTITY	Both CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells are required for IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats .
10072538	0	IFN-gamma	0,9	CD4	98,101	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|restore restore|nmod|mice mice|acl|depleted depleted|nmod|cells cells|compound|END_ENTITY	IFN-gamma and CD8 + T cells restore host defenses against Pneumocystis_carinii in mice depleted of CD4 + T cells .
10220431	0	IFN-gamma	94,103	CD4	0,3	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY T|ccomp|mediated T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma .
10403909	0	IFN-gamma	35,44	CD4	60,63	IFN-gamma	CD4	3458	920	Gene	Gene	IL-4|appos|START_ENTITY expression|nsubj|IL-4 expression|nmod|cells cells|compound|END_ENTITY	Reduced IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- expression by CD4 T cells in patients with chronic_lymphocytic_leukaemia .
10411927	0	IFN-gamma	91,100	CD4	0,3	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY eliminate|nmod|effects T|ccomp|eliminate T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma .
10454344	0	IFN-gamma	146,155	CD4	107,110	IFN-gamma	CD4	281237(Tax:9913)	407098(Tax:9913)	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production T|parataxis|enhances T|nsubj|effects effects|nmod|interleukin-12 interleukin-12|nmod|responses responses|nmod|+ +|compound|END_ENTITY	Comparative effects of interleukin-12 and interleukin-4 on cytokine responses by antigen-stimulated memory CD4 + T cells of cattle : IL-12 enhances IFN-gamma production , whereas IL-4 has marginal effects on cytokine expression .
10540183	0	IFN-gamma	55,64	CD4	19,22	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY cells|nmod|interferon-gamma T|dobj|cells T|nsubj|+ +|compound|END_ENTITY	In vitro activated CD4 + T cells from interferon-gamma -LRB- IFN-gamma -RRB- - deficient mice induce intestinal_inflammation in immunodeficient hosts .
10590258	0	IFN-gamma	169,178	CD4	0,3	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY epitope|nmod|production expressing|ccomp|epitope induced|xcomp|expressing cells|acl|induced T|dobj|cells T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p_1 independently of IFN-gamma production .
10944605	0	IFN-gamma	23,32	CD4	41,44	IFN-gamma	CD4	3458	920	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Enhanced expression of IFN-gamma mRNA in CD4 -LRB- + -RRB- or CD8 -LRB- + -RRB- tumour-infiltrating lymphocytes compared to peripheral lymphocytes in patients with renal_cell_cancer .
11123297	0	IFN-gamma	0,9	CD4	55,58	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY generated|nsubj|production generated|nmod|cells cells|compound|END_ENTITY	IFN-gamma production by Th1 cells generated from naive CD4 + T cells exposed to norepinephrine .
11160282	0	IFN-gamma	121,130	CD4	75,78	IFN-gamma	CD4	3458	920	Gene	Gene	requires|nmod|START_ENTITY requires|nsubj|inhibition inhibition|nmod|angiogenesis angiogenesis|nmod|cells cells|compound|END_ENTITY	IFN-gamma-dependent inhibition of tumor angiogenesis by tumor-infiltrating CD4 + T cells requires tumor responsiveness to IFN-gamma .
11207279	0	IFN-gamma	55,64	CD4	111,114	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY rejection|nmod|absence +|nmod|rejection +|acl:relcl|develop develop|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Immunobiology of allograft rejection in the absence of IFN-gamma : CD8 + effector cells develop independently of CD4 + cells and CD40-CD40 ligand interactions .
11359851	0	IFN-gamma	134,143	CD4	27,30	IFN-gamma	CD4	3458	920	Gene	Gene	ratios|amod|START_ENTITY subset|dep|ratios defines|dobj|subset defines|nsubj|CCR4 CCR4|nmod|cells cells|nummod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11380148	0	IFN-gamma	81,90	CD4	112,115	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Non-M protein -LRB- s -RRB- on the cell wall and membrane of group A streptococci induce -LRB- s -RRB- IFN-gamma production by dermal CD4 + T cells in psoriasis .
11465110	0	IFN-gamma	66,75	CD4	90,93	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Neonatal bacillus Calmette-Gu rin vaccination induces adult-like IFN-gamma production by CD4 + T lymphocytes .
11591752	0	IFN-gamma	149,158	CD4	114,117	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	mechanism|amod|START_ENTITY proliferation|nmod|mechanism T|dobj|proliferation T|nsubj|END_ENTITY	A schistosome-expressed immunomodulatory glycoconjugate expands peritoneal Gr1 -LRB- + -RRB- macrophages that suppress naive CD4 -LRB- + -RRB- T cell proliferation via an IFN-gamma and nitric_oxide-dependent mechanism .
11673565	0	IFN-gamma	6,15	CD4	49,52	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY rejection|nsubj|receptors rejection|amod|critical critical|nmod|T T|compound|END_ENTITY	Donor IFN-gamma receptors are critical for acute CD4 -LRB- + -RRB- T cell-mediated cardiac allograft rejection .
11971011	0	IFN-gamma	138,147	CD4	72,75	IFN-gamma	CD4	15978(Tax:10090)	920	Gene	Gene	antibodies|amod|START_ENTITY treated|nmod|antibodies mice|acl|treated cells|nmod|mice T|dobj|cells T|nsubj|production production|nmod|homolog homolog|nmod|END_ENTITY	Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4 -LRB- + -RRB- T cells in resistant mice treated once with anti-IL-12 or - IFN-gamma antibodies at the onset of infection with Leishmania_major instructs Th2 cell development , resulting in nonhealing lesions .
12060463	0	IFN-gamma	0,9	CD4	46,49	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	important|nsubj|START_ENTITY important|nmod|activation activation|compound|END_ENTITY	IFN-gamma but not IL-4 is important for mouse CD4 + T cell-mediated macrophage activation following their exposure to pig cells in vitro .
12444170	0	IFN-gamma	37,46	CD4	62,65	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	Th2|appos|START_ENTITY Th2|acl:relcl|cell cell|compound|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12496425	0	IFN-gamma	180,189	CD4	6,9	IFN-gamma	CD4	3458	920	Gene	Gene	effects|nmod|START_ENTITY kill|nmod|effects mobilized|xcomp|kill mobilized|nsubjpass|cells cells|compound|END_ENTITY	Human CD4 + T cells present within the microenvironment of human lung_tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-gamma .
12697666	0	IFN-gamma	135,144	CD4	95,98	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY signal|nmod|production signal|dep|Clustering Clustering|dobj|subunits subunits|nmod|T T|compound|END_ENTITY	Clustering of immunoreceptor tyrosine-based activation motif-containing signalling subunits in CD4 -LRB- + -RRB- T cells is an optimal signal for IFN-gamma production , but not for the production of IL-4 .
12902481	0	IFN-gamma	39,48	CD4	60,63	IFN-gamma	CD4	396054(Tax:9031)	395362(Tax:9031)	Gene	Gene	release|amod|START_ENTITY release|nmod|cells cells|nummod|END_ENTITY	IL-18 stimulates the proliferation and IFN-gamma release of CD4 + T cells in the chicken : conservation of a Th1-like system in a nonmammalian species .
12902504	0	IFN-gamma	86,95	CD4	115,118	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	DNA vaccines , combining form of antigen and method of delivery to raise a spectrum of IFN-gamma and IL-4-producing CD4 + and CD8 + T cells .
1354229	0	IFN-gamma	8,17	CD4	86,89	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphokine|nsubj|START_ENTITY lymphokine|nmod|mice mice|acl|depleted depleted|nmod|cells cells|compound|END_ENTITY	Altered IFN-gamma and IL-4 pattern lymphokine secretion in mice partially depleted of CD4 T cells by anti-CD4 monoclonal antibody .
14734762	0	IFN-gamma	72,81	CD4	96,99	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY down-regulation|nmod|production down-regulation|dep|cells cells|nummod|+ +|compound|END_ENTITY	Overproduction of TNF-alpha by CD8 + type 1 cells and down-regulation of IFN-gamma production by CD4 + Th1 cells contribute to toxic_shock-like_syndrome in an animal model of fatal monocytotropic ehrlichiosis .
15003314	0	IFN-gamma	88,97	CD4	53,56	IFN-gamma	CD4	3458	920	Gene	Gene	secretion|amod|START_ENTITY T|nmod|secretion T|nsubj|Isolation Isolation|nmod|+ +|compound|END_ENTITY	Isolation and expansion of human adenovirus-specific CD4 + and CD8 + T cells according to IFN-gamma secretion for adjuvant immunotherapy .
15153508	0	IFN-gamma	14,23	CD4	27,30	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Production of IFN-gamma by CD4 T cells is essential for resolving ehrlichia_infection .
15373901	0	IFN-gamma	22,31	CD4	0,3	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	producing|dobj|START_ENTITY cells|acl|producing cells|compound|END_ENTITY	CD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotype .
15388256	0	IFN-gamma	15,24	CD4	124,127	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY leads|nsubj|absence leads|nmod|responses responses|nmod|infection infection|acl|characterized characterized|nmod|increase increase|nmod|+ +|compound|END_ENTITY	The absence of IFN-gamma leads to increased Th2 responses after influenza_A_virus infection characterized by an increase in CD4 + but not CD8 + T cells producing IL-4 or IL-5 in the lung .
15451617	0	IFN-gamma	28,37	CD4	14,17	IFN-gamma	CD4	493965(Tax:9685)	493775(Tax:9685)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|Assessment Assessment|nmod|+ +|compound|END_ENTITY	Assessment of CD4 + and CD8 + IFN-gamma producing cells by ELISPOT in na ve and FIV-infected cats .
15611472	0	IFN-gamma	50,59	CD4	34,37	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY cells|nmod|mice cells|nummod|END_ENTITY	Impaired up-regulation of CD25 on CD4 + T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart_failure .
15634932	0	IFN-gamma	42,51	CD4	73,76	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4 + T cells .
15743488	0	IFN-gamma	150,159	CD4	10,13	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	counter-regulated|nmod|START_ENTITY pathogenesis|acl|counter-regulated factor|nmod|pathogenesis functioning|dep|factor functioning|compound|END_ENTITY	Defective CD4 + CD25 + regulatory T cell functioning in collagen-induced_arthritis : an important factor in pathogenesis , counter-regulated by endogenous IFN-gamma .
15814693	0	IFN-gamma	97,106	CD4	66,69	IFN-gamma	CD4	3458	920	Gene	Gene	responses|amod|START_ENTITY alloproliferation|dep|responses alloproliferation|compound|END_ENTITY	IL-12-independent LIGHT signaling enhances MHC class II disparate CD4 + T cell alloproliferation , IFN-gamma responses , and intestinal_graft-versus-host_disease .
15879087	0	IFN-gamma	47,56	CD4	71,74	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	TGF-beta_1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4 + T cells at priming and at recall : differential involvement of Stat4 and T-bet .
15935691	0	IFN-gamma	52,61	CD4	77,80	IFN-gamma	CD4	3458	920	Gene	Gene	production|appos|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Correlation between intracellular interferon-gamma -LRB- IFN-gamma -RRB- production by CD4 + and CD8 + lymphocytes and IFN-gamma gene polymorphism in patients with type 2 diabetes_mellitus and latent autoimmune diabetes of adults -LRB- LADA -RRB- .
15935883	0	IFN-gamma	40,49	CD4	101,104	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY controls|dobj|production controls|advcl|regulating regulating|dobj|effect effect|nmod|cells cells|compound|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
16002150	0	IFN-gamma	124,133	CD4	34,37	IFN-gamma	CD4	25712(Tax:10116)	24932(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion marrow-derived|ccomp|induces marrow-derived|nsubj|cells cells|amod|Activation Activation|nmod|T T|compound|END_ENTITY	Activation of purified allogeneic CD4 -LRB- + -RRB- T cells by rat bone marrow-derived dendritic cells induces concurrent secretion of IFN-gamma , IL-4 , and IL-10 .
16034093	0	IFN-gamma	107,116	CD4	138,141	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Direct stimulation of human T cells via TLR5 and TLR7/8 : flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4 + T cells .
16177085	0	IFN-gamma	0,9	CD4	48,51	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|generation/activation generation/activation|nmod|cells cells|compound|END_ENTITY	IFN-gamma controls the generation/activation of CD4 + CD25 + regulatory T cells in antitumor immune response .
16237051	0	IFN-gamma	20,29	CD4	76,79	IFN-gamma	CD4	3458	920	Gene	Gene	signaling|amod|START_ENTITY enhances|nsubj|signaling enhances|dobj|responses responses|compound|END_ENTITY	Cutting edge : early IFN-gamma signaling directly enhances primary antiviral CD4 + T cell responses .
1670604	0	IFN-gamma	51,60	CD4	20,23	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY lymphocytes|nmod|production lymphocytes|nsubj|role role|nmod|+ +|compound|END_ENTITY	Synergistic role of CD4 + and CD8 + T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma_gondii vaccine .
1674953	1	IFN-gamma	66,75	CD4	122,125	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	Hypersecretion|nmod|START_ENTITY necrosis|nsubj|Hypersecretion necrosis|nmod|cells cells|compound|END_ENTITY	Hypersecretion of IFN-gamma and tumor necrosis factor-alpha by stimulated CD4 + T cells .
16804321	0	IFN-gamma	85,94	CD4	76,79	IFN-gamma	CD4	3458	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Delayed allergic_reaction to suxamethonium driven by oligoclonal Th1-skewed CD4 + CCR4 + IFN-gamma + memory T cells .
16849446	0	IFN-gamma	14,23	CD4	81,84	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|induction induction|nmod|cells cells|compound|END_ENTITY	Cutting edge : IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial_infection .
16906223	0	IFN-gamma	8,17	CD4	58,61	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|CD25 CD25|compound|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
16906223	0	IFN-gamma	8,17	CD4	80,83	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|cells cells|nmod|Tregs Tregs|compound|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
17075267	0	IFN-gamma	80,89	CD4	16,19	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY cells|dobj|downregulation cells|nsubj|T T|compound|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
17334371	0	IFN-gamma	0,9	CD4	19,22	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|loss loss|nummod|END_ENTITY	IFN-gamma mediates CD4 + T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy .
17595676	0	IFN-gamma	0,9	CD4	51,54	IFN-gamma	CD4	3458	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IFN-gamma regulates Fas_ligand expression in human CD4 + T lymphocytes and controls their anti-mycobacterial cytotoxic functions .
17617585	0	IFN-gamma	0,9	CD4	37,40	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|cells cells|compound|END_ENTITY	IFN-gamma acts directly on activated CD4 + T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals .
17632036	0	IFN-gamma	14,23	CD4	43,46	IFN-gamma	CD4	3458	920	Gene	Gene	response|amod|START_ENTITY response|nmod|cells cells|compound|END_ENTITY	The secretory IFN-gamma response of single CD4 memory cells after activation on different antigen presenting cell types .
17662038	0	IFN-gamma	99,108	CD4	140,143	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Staphylococcus_aureus skin colonization in atopic_dermatitis children is associated with decreased IFN-gamma production by peripheral blood CD4 + and CD8 + T cells .
17851131	0	IFN-gamma	85,94	CD4	23,26	IFN-gamma	CD4	3458	920	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells inhibit|dobj|induction inhibit|nsubj|frequency frequency|nmod|CD25 CD25|compound|END_ENTITY	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
17851131	0	IFN-gamma	85,94	CD4	98,101	IFN-gamma	CD4	3458	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Increased frequency of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Treg cells inhibit BCG-specific induction of IFN-gamma by CD4 -LRB- + -RRB- T cells from TB patients .
17923502	0	IFN-gamma	101,110	CD4	27,30	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|nmod|production regulates|dobj|priming priming|compound|END_ENTITY	TAP-1 indirectly regulates CD4 + T cell priming in Toxoplasma_gondii_infection by controlling NK cell IFN-gamma production .
17947638	0	IFN-gamma	93,102	CD4	54,57	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|acetylation acetylation|nmod|promoter promoter|nmod|cells cells|compound|END_ENTITY	Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigen .
17982110	0	IFN-gamma	0,9	CD4	59,62	IFN-gamma	CD4	3458	920	Gene	Gene	cells|nummod|START_ENTITY cells|amod|produced produced|nmod|T T|compound|END_ENTITY	IFN-gamma produced by human_papilloma_virus-18 E6-specific CD4 + T cells predicts the clinical outcome after surgery in patients with high-grade cervical_lesions .
18158731	0	IFN-gamma	0,9	CD4	89,92	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytokine|nsubj|START_ENTITY cytokine|acl|found found|nmod|stimulation stimulation|nmod|cells cells|compound|END_ENTITY	IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4 + T cells from mice immunized with a chimeric VP6 protein .
18298587	0	IFN-gamma	67,76	CD4	58,61	IFN-gamma	CD4	3458	920	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Observational support for an immunoregulatory role of CD3 + CD4 + CD25 + IFN-gamma + blood lymphocytes in kidney transplant recipients with good long-term graft outcome .
18354166	0	IFN-gamma	8,17	CD4	56,59	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY enables|nsubj|Loss enables|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	Loss of IFN-gamma enables the expansion of autoreactive CD4 + T cells to induce experimental_autoimmune_encephalomyelitis by a nonencephalitogenic myelin variant antigen .
18388182	0	IFN-gamma	73,82	CD4	0,3	IFN-gamma	CD4	3458	920	Gene	Gene	produce|dobj|START_ENTITY inhibit|advcl|produce inhibit|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + CD25 + Treg cells inhibit human memory gammadelta T cells to produce IFN-gamma in response to M tuberculosis antigen ESAT-6 .
18453598	0	IFN-gamma	72,81	CD4	15,18	IFN-gamma	CD4	3458	920	Gene	Gene	leads|nmod|START_ENTITY Increasing|dep|leads Increasing|dobj|frequency frequency|compound|END_ENTITY	Increasing the CD4 + T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality .
18485335	0	IFN-gamma	52,61	CD4	84,87	IFN-gamma	CD4	3458	920	Gene	Gene	activated|nmod|START_ENTITY microglia|acl|activated OX40_ligand|nmod|microglia Expression|nmod|OX40_ligand sustains|nsubj|Expression sustains|dobj|response response|compound|END_ENTITY	Expression of OX40_ligand in microglia activated by IFN-gamma sustains a protective CD4 + T-cell response in vitro .
18802073	0	IFN-gamma	83,92	CD4	57,60	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	intestinal_inflammation|amod|START_ENTITY production|nmod|intestinal_inflammation production|compound|END_ENTITY	Goblet cell-derived resistin-like_molecule_beta augments CD4 + T cell production of IFN-gamma and infection-induced intestinal_inflammation .
19050105	0	IFN-gamma	0,9	CD4	99,102	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY involved|nsubjpass|expression involved|nmod|death death|compound|END_ENTITY	IFN-gamma expression in CD8 + T cells regulated by IL-6 signal is involved in superantigen-mediated CD4 + T cell death .
19200602	0	IFN-gamma	91,100	CD4	21,24	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY requires|dobj|production requires|nsubj|activation activation|nmod|cells cells|compound|END_ENTITY	Mutual activation of CD4 + T cells and monocytes mediated by NKG2D-MIC interaction requires IFN-gamma production in systemic_lupus_erythematosus .
19234226	0	IFN-gamma	101,110	CD4	75,78	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	End-organ damage in a mouse_model_of_fulminant_liver_inflammation requires CD4 + T cell production of IFN-gamma but is independent of Fas .
19242516	0	IFN-gamma	95,104	CD4	72,75	IFN-gamma	CD4	3458	920	Gene	Gene	producing|dobj|START_ENTITY cells|acl|producing Poly|dep|cells Poly|dep|cells cells|acl:relcl|promote promote|dobj|differentiation differentiation|nmod|T T|compound|END_ENTITY	Poly -LRB- I : C -RRB- - Treated human langerhans cells promote the differentiation of CD4 + T cells producing IFN-gamma and IL-10 .
19535638	0	IFN-gamma	0,9	CD4	49,52	IFN-gamma	CD4	3458	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|cells cells|compound|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19552791	0	IFN-gamma	8,17	CD4	47,50	IFN-gamma	CD4	3458	920	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|cells cells|compound|END_ENTITY	Reduced IFN-gamma - and enhanced IL-4-producing CD4 + cord blood T cells are associated with a higher risk for atopic_dermatitis during the first 2 yr of life .
1967279	0	IFN-gamma	92,101	CD4	14,17	IFN-gamma	CD4	3458	920	Gene	Gene	factor|compound|START_ENTITY produce|dobj|factor produce|nsubj|+ +|compound|END_ENTITY	Host-reactive CD4 + and CD8 + T cell clones isolated from a human chimera produce IL-5 , IL-2 , IFN-gamma and granulocyte/macrophage-colony-stimulating _ factor but not IL-4 .
1972722	1	IFN-gamma	114,123	CD4	79,82	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	secrete|dobj|START_ENTITY cells|acl:relcl|secrete T|dobj|cells T|nsubj|Frequencies Frequencies|nmod|+ +|compound|END_ENTITY	Frequencies of CD4 + and CD8 + T cells that secrete IFN-gamma and IL-5 .
19741155	0	IFN-gamma	87,96	CD4	0,3	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppressing|dobj|production attenuate|advcl|suppressing CD25|acl:relcl|attenuate CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells attenuate Hypersensitivity_Pneumonitis by suppressing IFN-gamma production by CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
19741155	0	IFN-gamma	87,96	CD4	111,114	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppressing|dobj|production suppressing|nmod|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells attenuate Hypersensitivity_Pneumonitis by suppressing IFN-gamma production by CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
19853929	0	IFN-gamma	86,95	CD4	25,28	IFN-gamma	CD4	3458	920	Gene	Gene	cells|dep|START_ENTITY CD25|nmod|cells T|nmod|CD25 T|nsubj|Conversion Conversion|nmod|CD25 CD25|compound|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19853929	0	IFN-gamma	86,95	CD4	50,53	IFN-gamma	CD4	3458	920	Gene	Gene	cells|dep|START_ENTITY CD25|nmod|cells CD25|compound|END_ENTITY	Conversion of peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells to CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells by IFN-gamma in patients with Guillain-Barr ___ syndrome .
19877012	0	IFN-gamma	23,32	CD4	46,49	IFN-gamma	CD4	3458	920	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Micro-RNA-155 inhibits IFN-gamma signaling in CD4 + T cells .
19957810	0	IFN-gamma	120,129	CD4	26,29	IFN-gamma	CD4	3458	920	Gene	Gene	levels|amod|START_ENTITY -RSB-|nsubj|levels -RSB-|advcl|-LSB- -LSB-|nmod|CD8 CD8|compound|END_ENTITY	-LSB- The relationship between CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T cells in the peripheral blood of patients with pancreatic_carcinoma and IL-4 , IFN-gamma levels -RSB- .
20117266	0	IFN-gamma	123,132	CD4	48,51	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY interplay|nmod|cells responses|dep|interplay T|dobj|responses T|nsubj|characterization characterization|nmod|END_ENTITY	Functional characterization of in vivo effector CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cell responses in acute Toxoplasmosis : an interplay of IFN-gamma and cytolytic T cells .
20156102	0	IFN-gamma	48,57	CD4	0,3	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY utilizing|nsubj|production inhibit|dep|utilizing T|ccomp|inhibit T|nsubj|CD25 CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells inhibit CD8 -LRB- + -RRB- IFN-gamma production during acute and chronic FIV_infection utilizing a membrane TGF-beta-dependent mechanism .
20364089	0	IFN-gamma	63,72	CD4	100,103	IFN-gamma	CD4	3458	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Control_of_vaccinia_virus skin_lesions by long-term-maintained IFN-gamma + TNF-alpha + effector/memory CD4 + lymphocytes in humans .
20544034	0	IFN-gamma	66,75	CD4	134,137	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY played|nmod|production played|nmod|END_ENTITY	Role of 4-1BB receptor in the control played by CD8 -LRB- + -RRB- T cells on IFN-gamma production by Mycobacterium_tuberculosis antigen-specific CD4 -LRB- + -RRB- T Cells .
20599915	0	IFN-gamma	132,141	CD4	145,148	IFN-gamma	CD4	3458	920	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nmod|+ +|compound|END_ENTITY	Ursolic_acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4 + na ve T cells .
2492048	0	IFN-gamma	27,36	CD4	60,63	IFN-gamma	CD4	3458	920	Gene	Gene	Treatment|nmod|START_ENTITY decreases|nsubj|Treatment decreases|dobj|levels levels|compound|END_ENTITY	Treatment with recombinant IFN-gamma decreases cell surface CD4 levels on peripheral blood monocytes and on myelomonocyte cell lines .
2573635	0	IFN-gamma	62,71	CD4	0,3	IFN-gamma	CD4	25712(Tax:10116)	24932(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY affect|dobj|production affect|nsubj|cells cells|compound|END_ENTITY	CD4 + suppressor cells differentially affect the production of IFN-gamma by effector cells of experimental_autoimmune_encephalomyelitis .
7530038	0	IFN-gamma	37,46	CD4	90,93	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	profile|amod|START_ENTITY profile|nmod|response response|compound|END_ENTITY	Rapid establishment of a stable IL-4 / IFN-gamma production profile in the antigen-specific CD4 + T cell response to protein immunization .
7594459	0	IFN-gamma	93,102	CD4	37,40	IFN-gamma	CD4	3458	920	Gene	Gene	produce|dobj|START_ENTITY inhibits|xcomp|produce inhibits|nsubj|cells cells|amod|Prostaglandin_E2 Prostaglandin_E2|nmod|priming priming|nmod|T T|compound|END_ENTITY	Prostaglandin_E2 at priming of naive CD4 + T cells inhibits acquisition of ability to produce IFN-gamma and IL-2 , but not IL-4 and IL-5 .
7722313	0	IFN-gamma	44,53	CD4	72,75	IFN-gamma	CD4	25712(Tax:10116)	24932(Tax:10116)	Gene	Gene	elicits|compound|START_ENTITY antitumor|nsubj|elicits antitumor|xcomp|cells cells|nsubj|T T|compound|END_ENTITY	Rat mammary adenocarcinoma 13762 expressing IFN-gamma elicits antitumor CD4 + MHC class II-restricted T cells that are cytolytic in vitro and tumoricidal in vivo .
7947460	0	IFN-gamma	26,35	CD4	81,84	IFN-gamma	CD4	3458	920	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|clones clones|compound|END_ENTITY	IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4 + allergen-specific Th2 T cell clones .
8097225	0	IFN-gamma	64,73	CD4	29,32	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY correlates|nmod|production correlates|nsubj|activity activity|nmod|clones clones|compound|END_ENTITY	Cytolytic activity of murine CD4 + T cell clones correlates with IFN-gamma production in mouse strains having a BALB/c background .
8370421	0	IFN-gamma	0,9	CD4	37,40	IFN-gamma	CD4	3458	920	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|+ +|compound|END_ENTITY	IFN-gamma and TNF-alpha secretion by CD4 + and CD8 + TCR alpha beta + T-cell clones derived early after allogeneic bone marrow transplantation .
8553586	0	IFN-gamma	167,176	CD4	84,87	IFN-gamma	CD4	3458	920	Gene	Gene	production|nmod|START_ENTITY responses|nmod|production infected|nmod|responses infected|nmod|results results|compound|END_ENTITY	Transmission of HIV-1 from productively infected mature Langerhans cells to primary CD4 + T lymphocytes results in altered T cell responses with enhanced production of IFN-gamma and IL-10 .
8635694	0	IFN-gamma	90,99	CD4	57,60	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY associated|nmod|production associated|nsubjpass|Expression Expression|nmod|protein protein|nmod|cells cells|compound|END_ENTITY	Expression and release of LAG-3-encoded protein by human CD4 + T cells are associated with IFN-gamma production .
8786299	0	IFN-gamma	80,89	CD4	63,66	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	enhance|nmod|START_ENTITY enhance|dobj|priming priming|nmod|cells cells|compound|END_ENTITY	High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4 + T cells for IFN-gamma but have differential effects on priming for IL-4 .
8921430	0	IFN-gamma	79,88	CD4	109,112	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes .
9127013	0	IFN-gamma	118,127	CD4	85,88	IFN-gamma	CD4	574282(Tax:9544)	713807(Tax:9544)	Gene	Gene	secrete|dobj|START_ENTITY cells|acl:relcl|secrete cells|compound|END_ENTITY	HIV-1 env DNA vaccine administered to rhesus_monkeys elicits MHC class II-restricted CD4 + T helper cells that secrete IFN-gamma and TNF-alpha .
9218571	0	IFN-gamma	35,44	CD4	77,80	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Melatonin enhances IL-2 , IL-6 , and IFN-gamma production by human circulating CD4 + cells : a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes .
9344500	0	IFN-gamma	105,114	CD4	40,43	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY priming|nmod|production signals|nmod|priming provide|nmod|signals provide|dobj|cells cells|compound|END_ENTITY	Prostaglandin_E2 and IL-4 provide naive CD4 + T cells with distinct inhibitory signals for the priming of IFN-gamma production .
9510174	0	IFN-gamma	96,105	CD4	0,3	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY have|dobj|production T|ccomp|have T|nsubj|+ +|compound|END_ENTITY	CD4 + , but not CD8 + , T cells from mammary_tumor-bearing mice have a down-regulated production of IFN-gamma : role of phosphatidyl_serine .
9590250	0	IFN-gamma	37,46	CD4	0,3	IFN-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	CD4 + and CD8 + T cell interactions in IFN-gamma and IL-4 responses to viral_infections : requirements for IL-2 .
9759858	0	IFN-gamma	117,126	CD4	140,143	IFN-gamma	CD4	3458	920	Gene	Gene	secretion|amod|START_ENTITY IL-12-mediated|dobj|secretion IL-12-mediated|nmod|cells cells|compound|END_ENTITY	IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4 + T cells in the absence of TCR ligation .
9809616	0	IFN-gamma	59,68	CD4	89,92	IFN-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nmod|cells cells|compound|END_ENTITY	Bacterial extract OM85-BV induces interleukin-12-dependent IFN-gamma production by human CD4 + T cells .
9822276	0	IFN-gamma	18,27	CD4	124,127	IFN-gamma	CD4	3458	920	Gene	Gene	Interferon-gamma|appos|START_ENTITY necessary|nsubj|Interferon-gamma necessary|nmod|stages stages|nmod|induction induction|nmod|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium_leprae heat_shock protein -LRB- hsp -RRB- 65 kD .
10201939	0	IFN-gamma	94,103	CD40	0,4	IFN-gamma	CD40	3458	958	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|interaction interaction|nummod|END_ENTITY	CD40 ligand-CD40 interaction induces chemokines in cervical_carcinoma cells in synergism with IFN-gamma .
10510353	0	IFN-gamma	25,34	CD40	89,93	IFN-gamma	CD40	3458	958	Gene	Gene	Integrating|nmod|START_ENTITY Integrating|parataxis|switching switching|nsubj|effects effects|nmod|proliferation proliferation|nummod|END_ENTITY	Integrating signals from IFN-gamma and IL-4 by B cells : positive and negative effects on CD40 ligand-induced proliferation , survival , and division-linked isotype switching to IgG1 , IgE , and IgG2a .
12950679	0	IFN-gamma	61,70	CD40	22,26	IFN-gamma	CD40	15978(Tax:10090)	21939(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
16864989	0	IFN-gamma	67,76	CD40	40,44	IFN-gamma	CD40	3458	958	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|15d-PGJ2 15d-PGJ2|nmod|expression expression|nmod|END_ENTITY	Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells -LRB- HK-2 -RRB- .
17015727	0	IFN-gamma	71,80	CD40	40,44	IFN-gamma	CD40	15978(Tax:10090)	21939(Tax:10090)	Gene	Gene	ligation|nmod|START_ENTITY ligation|nsubj|expression expression|nmod|gamma2a gamma2a|nmod|END_ENTITY	Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma .
19171874	0	IFN-gamma	13,22	CD40	70,74	IFN-gamma	CD40	3458	958	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells .
9469427	0	IFN-gamma	57,66	CD40	12,16	IFN-gamma	CD40	3458	958	Gene	Gene	production|nmod|START_ENTITY regulates|dobj|production regulates|nsubj|stimulation stimulation|compound|END_ENTITY	CD40_ligand / CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12 - and/or CD28-dependent manner .
10413659	0	IFN-gamma	9,18	CD8	42,45	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|amod|vitro vitro|nmod|T T|compound|END_ENTITY	Enhanced IFN-gamma production in vitro by CD8 + T cells in hemophiliacs with AIDS as demonstrated on the single-cell level .
10551378	0	IFN-gamma	23,32	CD8	55,58	IFN-gamma	CD8	3458	925	Gene	Gene	levels|amod|START_ENTITY intracellular|dobj|levels intracellular|advcl|circulating circulating|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	Elevated intracellular IFN-gamma levels in circulating CD8 + lymphocytes in patients with fulminant_hepatitis .
10636490	0	IFN-gamma	16,25	CD8	27,30	IFN-gamma	CD8	3458	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	HTLV-I specific IFN-gamma + CD8 + lymphocytes correlate with the proviral load in peripheral blood of infected individuals .
10799875	0	IFN-gamma	137,146	CD8	41,44	IFN-gamma	CD8	3458	925	Gene	Gene	lymphocyte|nmod|START_ENTITY lymphocyte|nsubj|T T|compound|END_ENTITY	Monophosphoryl_lipid_A and QS21 increase CD8 T lymphocyte cytotoxicity to herpes_simplex_virus-2 infected cell proteins 4 and 27 through IFN-gamma and IL-12 production .
10861058	0	IFN-gamma	29,38	CD8	42,45	IFN-gamma	CD8	3458	925	Gene	Gene	contribution|nmod|START_ENTITY contribution|nmod|rejection rejection|compound|END_ENTITY	An essential contribution by IFN-gamma to CD8 + T cell-mediated rejection of pancreatic islet allografts .
10925295	0	IFN-gamma	28,37	CD8	56,59	IFN-gamma	CD8	3458	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of intracellular IFN-gamma in HSV-1-specific CD8 + T cells identifies distinct responding subpopulations during the primary response to infection .
10964541	0	IFN-gamma	16,25	CD8	80,83	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY increase|nmod|production increase|nmod|correlates correlates|nmod|END_ENTITY	The increase of IFN-gamma production through aging correlates with the expanded CD8 -LRB- + high -RRB- CD28 -LRB- - -RRB- CD57 -LRB- + -RRB- subpopulation .
11012976	0	IFN-gamma	118,127	CD8	22,25	IFN-gamma	CD8	3458	925	Gene	Gene	ELISPOT|compound|START_ENTITY identification|nmod|ELISPOT identification|dep|responses responses|compound|END_ENTITY	HLA-A * 0201 restricted CD8 + T-lymphocyte responses to malaria : identification of new Plasmodium_falciparum epitopes by IFN-gamma ELISPOT .
11167992	0	IFN-gamma	118,127	CD8	143,146	IFN-gamma	CD8	3458	925	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Patients with inflammatory_bowel_disease -LRB- IBD -RRB- reveal increased induction capacity of intracellular interferon-gamma -LRB- IFN-gamma -RRB- in peripheral CD8 + lymphocytes co-cultured with intestinal epithelial cells .
11390521	0	IFN-gamma	8,17	CD8	43,46	IFN-gamma	CD8	3458	925	Gene	Gene	START_ENTITY|acl|secretion secretion|advcl|circulating circulating|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes : implications of a novel approach for T cell monitoring in infectious and malignant_diseases .
11730845	0	IFN-gamma	104,113	CD8	80,83	IFN-gamma	CD8	3458	925	Gene	Gene	assays|amod|START_ENTITY lymphocytes|nmod|assays lymphocytes|nsubj|use use|nmod|T T|compound|END_ENTITY	The use of HLA-A * 0201-transfected K562 as standard antigen-presenting_cells for CD8 -LRB- + -RRB- T lymphocytes in IFN-gamma ELISPOT assays .
11825525	0	IFN-gamma	20,29	CD8	59,62	IFN-gamma	CD8	3458	925	Gene	Gene	assay|amod|START_ENTITY assay|nmod|END_ENTITY	-LSB- Application of the IFN-gamma ELISPOT assay for monitoring CD8 -LRB- + -RRB- T cell response to specific antigen from hepatocellular_carcinoma patients -RSB- .
14579273	0	IFN-gamma	0,9	CD8	65,68	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY NK|nsubj|production NK|nmod|engagement engagement|nmod|END_ENTITY	IFN-gamma production in human NK cells through the engagement of CD8 by soluble or surface HLA class I molecules .
14698862	0	IFN-gamma	96,105	CD8	120,123	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Cyclophosphamide modulates CD4 + T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8 + T cells in secondary progressive multiple_sclerosis .
15210805	0	IFN-gamma	61,70	CD8	39,42	IFN-gamma	CD8	3458	925	Gene	Gene	synthesis|amod|START_ENTITY initiate|dobj|synthesis initiate|nsubj|cells cells|compound|END_ENTITY	The rapidity with which virus-specific CD8 + T cells initiate IFN-gamma synthesis increases markedly over the course of infection and correlates with immunodominance .
15384046	0	IFN-gamma	66,75	CD8	95,98	IFN-gamma	CD8	3458	925	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Reduced antigen concentration and costimulatory blockade increase IFN-gamma secretion in naive CD8 + T cells .
15629089	0	IFN-gamma	14,23	CD8	40,43	IFN-gamma	CD8	3458	925	Gene	Gene	level|amod|START_ENTITY level|nmod|cell cell|compound|END_ENTITY	-LSB- Detection of IFN-gamma level in single CD8 + T cell -RSB- .
15814691	0	IFN-gamma	31,40	CD8	83,86	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8 + effector T cells .
15922715	0	IFN-gamma	79,88	CD8	56,59	IFN-gamma	CD8	3458	925	Gene	Gene	produce|dobj|START_ENTITY promotes|xcomp|produce promotes|dobj|cells cells|compound|END_ENTITY	A human Langerhans cell-like cell line , ELD-1 , promotes CD8 T cells to produce IFN-gamma through CD70-dependent alternative pathway .
16246570	0	IFN-gamma	31,40	CD8	51,54	IFN-gamma	CD8	3458	925	Gene	Gene	T-cells|amod|START_ENTITY T-cells|compound|END_ENTITY	Association between peripheral IFN-gamma producing CD8 + T-cells and disability score in relapsing-remitting multiple_sclerosis .
16352669	0	IFN-gamma	64,73	CD8	52,55	IFN-gamma	CD8	3458	925	Gene	Gene	expression|amod|START_ENTITY T|dep|expression T|compound|END_ENTITY	Effect of medical castration on CD4 + CD25 + T cells , CD8 + T cell IFN-gamma expression , and NK cells : a physiological role for testosterone and/or its metabolites .
16441508	0	IFN-gamma	14,23	CD8	38,41	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY production|nmod|T T|compound|END_ENTITY	Evaluation of IFN-gamma production by CD8 T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma_cruzi .
16818762	0	IFN-gamma	38,47	CD8	63,66	IFN-gamma	CD8	3458	925	Gene	Gene	loci|amod|START_ENTITY loci|nmod|cells cells|compound|END_ENTITY	Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells .
16920922	0	IFN-gamma	61,70	CD8	50,53	IFN-gamma	CD8	3458	925	Gene	Gene	responses|amod|START_ENTITY Overcoming|nsubj|responses Overcoming|advcl|generate generate|dobj|END_ENTITY	Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen-experienced host .
17222752	0	IFN-gamma	22,31	CD8	62,65	IFN-gamma	CD8	15978(Tax:10090)	925	Gene	Gene	role|nmod|START_ENTITY role|nmod|cells cells|compound|END_ENTITY	An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation .
17277117	0	IFN-gamma	5,14	CD8	40,43	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY production|nmod|lymphocytes lymphocytes|compound|END_ENTITY	High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 -LRB- CTLA-4 -RRB- .
17404259	0	IFN-gamma	51,60	CD8	80,83	IFN-gamma	CD8	3458	925	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|memory memory|compound|END_ENTITY	Profound enhancement of the IL-12 / IL-18 pathway of IFN-gamma secretion in human CD8 + memory T cell subsets via IL-15 .
17675470	0	IFN-gamma	26,35	CD8	68,71	IFN-gamma	CD8	3458	925	Gene	Gene	effects|nmod|START_ENTITY Role|nmod|effects Role|nmod|regulation regulation|nmod|homeostasis homeostasis|compound|END_ENTITY	Role of direct effects of IFN-gamma on T cells in the regulation of CD8 T cell homeostasis .
19535638	0	IFN-gamma	0,9	CD8	90,93	IFN-gamma	CD8	3458	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|cells cells|ccomp|suppress suppress|dobj|generation generation|nmod|responses responses|nummod|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19957810	0	IFN-gamma	120,129	CD8	33,36	IFN-gamma	CD8	3458	925	Gene	Gene	levels|amod|START_ENTITY -RSB-|nsubj|levels -RSB-|advcl|-LSB- -LSB-|nmod|END_ENTITY	-LSB- The relationship between CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- T cells in the peripheral blood of patients with pancreatic_carcinoma and IL-4 , IFN-gamma levels -RSB- .
20156102	0	IFN-gamma	48,57	CD8	41,44	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cells inhibit CD8 -LRB- + -RRB- IFN-gamma production during acute and chronic FIV_infection utilizing a membrane TGF-beta-dependent mechanism .
20562261	0	IFN-gamma	0,9	CD8	62,65	IFN-gamma	CD8	3458	925	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|compound|END_ENTITY	IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response .
20889558	0	IFN-gamma	68,77	CD8	95,98	IFN-gamma	CD8	3458	925	Gene	Gene	role|nmod|START_ENTITY mechanisms|dep|role mechanisms|dep|T T|compound|END_ENTITY	Host defense mechanisms in secondary syphilitic lesions : a role for IFN-gamma - / IL-17-producing CD8 + T cells ?
7569779	0	IFN-gamma	106,115	CD8	63,66	IFN-gamma	CD8	3458	925	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Suppression Suppression|nmod|autoimmune_myasthenia_gravis autoimmune_myasthenia_gravis|nmod|depletion depletion|compound|END_ENTITY	Suppression of experimental autoimmune_myasthenia_gravis after CD8 depletion is associated with decreased IFN-gamma and IL-4 .
8148319	0	IFN-gamma	125,134	CD8	145,148	IFN-gamma	CD8	3458	925	Gene	Gene	START_ENTITY|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	Quantitation of human influenza virus-specific cytotoxic T lymphocytes : correlation of cytotoxicity and increased numbers of IFN-gamma producing CD8 + T cells .
8964081	0	IFN-gamma	48,57	CD8	74,77	IFN-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY production|nmod|clone clone|compound|END_ENTITY	Difference in signal transduction for IL-10 and IFN-gamma production in a CD8 + T cell clone .
9207753	0	IFN-gamma	111,120	CD8	36,39	IFN-gamma	CD8	3458	925	Gene	Gene	IL-6|nmod|START_ENTITY cells|dep|IL-6 cells|nummod|END_ENTITY	Differential development of CD4 and CD8 cytotoxic T cells -LRB- CTL -RRB- in PBMC across the leprosy spectrum ; IL-6 with IFN-gamma or IL-2 generate CTL in multibacillary patients .
9472663	0	IFN-gamma	169,178	CD8	18,21	IFN-gamma	CD8	3458	925	Gene	Gene	interferon-gamma|appos|START_ENTITY production|nmod|interferon-gamma abnormalities|nmod|production defect|dep|abnormalities defect|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9472663	0	IFN-gamma	169,178	CD8	228,231	IFN-gamma	CD8	3458	925	Gene	Gene	interferon-gamma|appos|START_ENTITY production|nmod|interferon-gamma abnormalities|nmod|production defect|dep|abnormalities defect|dep|+ +|compound|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9820134	0	IFN-gamma	14,23	CD8	73,76	IFN-gamma	CD8	3458	925	Gene	Gene	expression|amod|START_ENTITY precedes|nsubj|expression precedes|dobj|recruitment recruitment|compound|END_ENTITY	Intracellular IFN-gamma expression in natural killer cells precedes lung CD8 + T cell recruitment during respiratory_syncytial_virus_infection .
9144510	0	IFN-gamma	23,32	CD80	79,83	IFN-gamma	CD80	15978(Tax:10090)	12519(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 -LRB- B7-1 -RRB- but not CD86 -LRB- B7-2 -RRB- on murine fibroblasts .
8955209	0	IFN-gamma	63,72	CD88	54,58	IFN-gamma	CD88	3458	728	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of the C3a and C5a_receptors -LRB- CD88 -RRB- by IFN-gamma and PMA in U937 cells and related myeloblastic cell lines .
11053628	0	IFN-gamma	142,151	CIITA	180,185	IFN-gamma	CIITA	3458	4261	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter -LRB- PIV -RRB- of CIITA .
15128827	0	IFN-gamma	56,65	CXC-chemokine_ligand_16	18,41	IFN-gamma	CXC-chemokine ligand 16	15978(Tax:10090)	66102(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The transmembrane CXC-chemokine_ligand_16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10 .
12115663	0	IFN-gamma	146,155	CXCR3	36,41	IFN-gamma	CXCR3	3458	2833	Gene	Gene	stimulation|amod|START_ENTITY dependence|nmod|stimulation Induction|dep|dependence Induction|nmod|END_ENTITY	Induction of the chemokine receptor CXCR3 on TCR-stimulated T cells : dependence on the release from persistent TCR-triggering and requirement for IFN-gamma stimulation .
14498985	0	IFN-gamma	14,23	CXCR3	32,37	IFN-gamma	CXCR3	574282(Tax:9544)	699438(Tax:9544)	Gene	Gene	Expression|nmod|START_ENTITY induced|nsubj|Expression induced|dobj|chemokines chemokines|nummod|END_ENTITY	Expression of IFN-gamma induced CXCR3 agonist chemokines and compartmentalization of CXCR3 + cells in the periphery and lymph nodes of rhesus_macaques during simian immunodeficiency_virus_infection and acquired_immunodeficiency_syndrome .
14498985	0	IFN-gamma	14,23	CXCR3	85,90	IFN-gamma	CXCR3	574282(Tax:9544)	699438(Tax:9544)	Gene	Gene	Expression|nmod|START_ENTITY induced|nsubj|Expression induced|nmod|cells cells|nummod|END_ENTITY	Expression of IFN-gamma induced CXCR3 agonist chemokines and compartmentalization of CXCR3 + cells in the periphery and lymph nodes of rhesus_macaques during simian immunodeficiency_virus_infection and acquired_immunodeficiency_syndrome .
16547278	0	IFN-gamma	59,68	CXCR3	83,88	IFN-gamma	CXCR3	15978(Tax:10090)	12766(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Severe_disease , unaltered leukocyte migration , and reduced IFN-gamma production in CXCR3 - / - mice with experimental autoimmune encephalomyelitis .
15837745	0	IFN-gamma	47,56	CXCR4	14,19	IFN-gamma	CXCR4	3458	7852	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CXCR4 and its down-regulation by IFN-gamma in head and neck_squamous_cell_carcinoma .
9378988	0	IFN-gamma	0,9	E-selectin	47,57	IFN-gamma	E-selectin	3458	6401	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	IFN-gamma inhibits double-stranded RNA-induced E-selectin expression in human endothelial cells .
1697876	0	IFN-gamma	0,9	ELAM-1	60,66	IFN-gamma	ELAM-1	3458	6401	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro .
20056084	0	IFN-gamma	49,58	Eomes	40,45	IFN-gamma	Eomes	3458	8320	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different human T cell subsets -RSB- .
17595676	0	IFN-gamma	0,9	Fas_ligand	20,30	IFN-gamma	Fas ligand	3458	356	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IFN-gamma regulates Fas_ligand expression in human CD4 + T lymphocytes and controls their anti-mycobacterial cytotoxic functions .
2141616	0	IFN-gamma	60,69	Fc_gamma_RI	40,51	IFN-gamma	Fc gamma RI	3458	2209	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Regulation of the steady state level of Fc_gamma_RI mRNA by IFN-gamma and dexamethasone in human monocytes , neutrophils , and U-937 cells .
1311348	0	IFN-gamma	0,9	Fc_gamma_RIII	32,45	IFN-gamma	Fc gamma RIII	3458	2214	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IFN-gamma induces expression of Fc_gamma_RIII -LRB- CD16 -RRB- on human eosinophils .
19109154	0	IFN-gamma	63,72	Follistatin-like_protein_1	0,26	IFN-gamma	Follistatin-like protein 1	15978(Tax:10090)	14314(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Follistatin-like_protein_1 promotes arthritis by up-regulating IFN-gamma .
16906223	0	IFN-gamma	8,17	Foxp3	34,39	IFN-gamma	Foxp3	15978(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Role of IFN-gamma in induction of Foxp3 and conversion of CD4 + CD25 - T cells to CD4 + Tregs .
11777952	0	IFN-gamma	63,72	Fractalkine	0,11	IFN-gamma	Fractalkine	3458	6376	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity .
10828862	0	IFN-gamma	14,23	G-CSF	0,5	IFN-gamma	G-CSF	25712(Tax:10116)	25610(Tax:10116)	Gene	Gene	production|amod|START_ENTITY reduces|dobj|production reduces|nsubj|END_ENTITY	G-CSF reduces IFN-gamma and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function .
10227805	0	IFN-gamma	35,44	GATA-3	0,6	IFN-gamma	GATA-3	3458	2625	Gene	Gene	production|amod|START_ENTITY downregulates|dobj|production downregulates|nsubj|END_ENTITY	GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels .
14761115	0	IFN-gamma	31,40	GCF	27,30	IFN-gamma	GCF	3458	6936	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Longitudinal evaluation of GCF IFN-gamma levels and periodontal status in HIV + patients .
2834073	0	IFN-gamma	79,88	GMCSF	144,149	IFN-gamma	GMCSF	3458	1437	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	A novel human macrophage-activating_factor : distinction from interferon-gamma -LRB- IFN-gamma -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GMCSF -RRB- .
17475886	0	IFN-gamma	35,44	Gpnmb	0,5	IFN-gamma	Gpnmb	15978(Tax:10090)	93695(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses .
8666791	0	IFN-gamma	79,88	HLA-G	14,19	IFN-gamma	HLA-G	3458	3135	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of HLA-G in human mononuclear phagocytes and selective induction by IFN-gamma .
9066649	0	IFN-gamma	11,20	HLA_class_I_antigen	61,80	IFN-gamma	HLA class I antigen	3458	100507436	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of IFN-gamma , TNF-alpha and EGF on the expression of HLA_class_I_antigen and the proliferation of human hepatocellular_carcinoma HepG2 cells .
18497994	0	IFN-gamma	0,9	Hsp27	25,30	IFN-gamma	Hsp27	3458	3315	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	IFN-gamma down-regulates Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo .
11795279	0	IFN-gamma	108,117	I-TAC	80,85	IFN-gamma	I-TAC	3458	6373	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Lysophosphatidylcholine inhibits T cell-specific CXC chemokines IP-10 , MIG , and I-TAC expression induced by IFN-gamma in human endothelial cells .
7740833	0	IFN-gamma	45,54	ICAM-1	13,19	IFN-gamma	ICAM-1	3458	3383	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of ICAM-1 and HLA-DR expression by IFN-gamma in malignant_melanoma cell lines .
10656176	0	IFN-gamma	59,68	IFN-alpha	26,35	IFN-gamma	IFN-alpha	3458	3439	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Role of interferon alpha -LRB- IFN-alpha -RRB- and interferon gamma -LRB- IFN-gamma -RRB- in the control of the infection of monocyte-like cells with human_cytomegalovirus _ -LRB- HCMV -RRB- .
11449378	0	IFN-gamma	132,141	IFN-alpha	161,170	IFN-gamma	IFN-alpha	3458	3439	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells : differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12 .
8807500	0	IFN-gamma	0,9	IFN-alpha	33,42	IFN-gamma	IFN-alpha	3458	3439	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	IFN-gamma enhances production of IFN-alpha in human macrophages but not in monocytes .
9475662	0	IFN-gamma	108,117	IFN-alpha	20,29	IFN-gamma	IFN-alpha	15978(Tax:10090)	111654(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Orally administered IFN-alpha acts alone and in synergistic combination with intraperitoneally administered IFN-gamma to exert an antitumor effect against B16_melanoma in mice .
10805211	0	IFN-gamma	135,144	IFN-gamma	163,172	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Essential pathogenetic role for interferon _ -LRB- IFN - -RRB- gamma in concanavalin A-induced T cell-dependent hepatitis : exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein .
10805211	0	IFN-gamma	163,172	IFN-gamma	135,144	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Essential pathogenetic role for interferon _ -LRB- IFN - -RRB- gamma in concanavalin A-induced T cell-dependent hepatitis : exacerbation by exogenous IFN-gamma and prevention by IFN-gamma receptor-immunoglobulin fusion protein .
14607968	0	IFN-gamma	0,9	IFN-gamma	25,34	IFN-gamma	IFN-gamma	3458	3458	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|dep|END_ENTITY	IFN-gamma polymorphisms -LRB- IFN-gamma +2109 and IFN-gamma +3810 -RRB- are associated with severe hepatic fibrosis in human hepatic_schistosomiasis -LRB- Schistosoma_mansoni -RRB- .
14607968	0	IFN-gamma	25,34	IFN-gamma	0,9	IFN-gamma	IFN-gamma	3458	3458	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|amod|END_ENTITY	IFN-gamma polymorphisms -LRB- IFN-gamma +2109 and IFN-gamma +3810 -RRB- are associated with severe hepatic fibrosis in human hepatic_schistosomiasis -LRB- Schistosoma_mansoni -RRB- .
7499845	0	IFN-gamma	127,136	IFN-gamma	18,27	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|sites sites|amod|END_ENTITY	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
7499845	0	IFN-gamma	127,136	IFN-gamma	90,99	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
7499845	0	IFN-gamma	18,27	IFN-gamma	127,136	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	sites|amod|START_ENTITY Identification|nmod|sites Identification|nmod|END_ENTITY	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
7499845	0	IFN-gamma	90,99	IFN-gamma	127,136	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
8245462	0	IFN-gamma	27,36	IFN-gamma	50,59	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Binding site on the murine IFN-gamma receptor for IFN-gamma has been identified using the synthetic peptide approach .
8245462	0	IFN-gamma	50,59	IFN-gamma	27,36	IFN-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Binding site on the murine IFN-gamma receptor for IFN-gamma has been identified using the synthetic peptide approach .
17996064	0	IFN-gamma	12,21	IFN-gamma-inducible_protein_10	39,69	IFN-gamma	IFN-gamma-inducible protein 10	3458	3627	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	The role of IFN-gamma in regulation of IFN-gamma-inducible_protein_10 -LRB- IP-10 -RRB- expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures .
9605150	0	IFN-gamma	0,9	IFN-stimulated_gene_factor_3	31,59	IFN-gamma	IFN-stimulated gene factor 3	3458	6772	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	IFN-gamma priming up-regulates IFN-stimulated_gene_factor_3 -LRB- ISGF3 -RRB- components , augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs .
10505747	0	IFN-gamma	15,24	IFNG	31,35	IFN-gamma	IFNG	3458	3458	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of an IFN-gamma gene -LRB- IFNG -RRB- polymorphism in multiple_sclerosis in Europe : effect of population structure on association with disease .
12794166	0	IFN-gamma	159,168	IFN_consensus_sequence-binding_protein	25,63	IFN-gamma	IFN consensus sequence-binding protein	3458	3394	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Coordinate regulation of IFN_consensus_sequence-binding_protein and caspase-1 in the sensitization of human colon_carcinoma cells to Fas-mediated apoptosis by IFN-gamma .
2114443	0	IFN-gamma	65,74	IL-1	27,31	IFN-gamma	IL-4	3458	3565	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4 .
10447735	0	IFN-gamma	32,41	IL-10	74,79	IFN-gamma	IL-10	3458	3586	Gene	Gene	Th1-type|appos|START_ENTITY Th1-type|appos|END_ENTITY	Regulatory effects of Th1-type -LRB- IFN-gamma , IL-12 -RRB- and Th2-type cytokines -LRB- IL-10 , IL-13 -RRB- on parasite-specific cellular responsiveness in Onchocerca_volvulus-infected humans and exposed endemic controls .
10508240	0	IFN-gamma	69,78	IL-10	0,5	IFN-gamma	IL-10	3458	3586	Gene	Gene	proliferation|nmod|START_ENTITY enhances|dobj|proliferation enhances|nsubj|END_ENTITY	IL-10 enhances NK cell proliferation , cytotoxicity and production of IFN-gamma when combined with IL-18 .
11323220	0	IFN-gamma	19,28	IL-10	0,5	IFN-gamma	IL-10	3458	3586	Gene	Gene	augments|dobj|START_ENTITY augments|nsubj|END_ENTITY	IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells : a possible mechanism in the inflammatory reaction of atopic_dermatitis .
11994711	0	IFN-gamma	116,125	IL-10	56,61	IFN-gamma	IL-10	3458	3586	Gene	Gene	elevation|nmod|START_ENTITY END_ENTITY|nmod|elevation	Suppression of human anti-inflammatory plasma cytokines IL-10 and IL-1RA with elevation of proinflammatory cytokine IFN-gamma during the isolation of the Antarctic winter .
12168827	1	IFN-gamma	164,173	IL-10	175,180	IFN-gamma	IL-10	3458	3586	Gene	Gene	balance|amod|START_ENTITY balance|compound|END_ENTITY	Correlation with the IFN-gamma : IL-10 balance .
12193230	0	IFN-gamma	44,53	IL-10	55,60	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
12517950	0	IFN-gamma	0,9	IL-10	50,55	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	IFN-gamma production is specifically regulated by IL-10 in mice made tolerant with anti-CD40 ligand antibody and intact active bone .
12734375	0	IFN-gamma	68,77	IL-10	19,24	IFN-gamma	IL-10	3458	3586	Gene	Gene	production|amod|START_ENTITY inhibit|dobj|production modes|acl|inhibit modes|nmod|END_ENTITY	Different modes of IL-10 and TGF-beta to inhibit cytokine-dependent IFN-gamma production : consequences for reversal of lipopolysaccharide desensitization .
14568953	0	IFN-gamma	45,54	IL-10	0,5	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	response|amod|START_ENTITY suppression|nmod|response mediates|dobj|suppression mediates|nsubj|END_ENTITY	IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host .
16301610	0	IFN-gamma	70,79	IL-10	52,57	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppress|dobj|production END_ENTITY|xcomp|suppress	Cutting edge : CD8 + CD122 + regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8 + T cells .
16461742	0	IFN-gamma	128,137	IL-10	104,109	IFN-gamma	IL-10	3458	3586	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Regulation of PTX3 , a key component of humoral innate immunity in human dendritic cells : stimulation by IL-10 and inhibition by IFN-gamma .
16713974	0	IFN-gamma	0,9	IL-10	21,26	IFN-gamma	IL-10	3458	3586	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP -1 proteins .
16944581	0	IFN-gamma	115,124	IL-10	108,113	IFN-gamma	IL-10	3458	3586	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Regulation of vitality and IL-10 receptor expression of human decidual stromal cells in early pregnancy by IL-10 , IFN-gamma -RSB- .
17182557	0	IFN-gamma	0,9	IL-10	43,48	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IFN-gamma negatively regulates CpG-induced IL-10 in bone marrow-derived dendritic cells .
17689526	0	IFN-gamma	39,48	IL-10	118,123	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	response|amod|START_ENTITY suppresses|dobj|response suppresses|parataxis|role role|nmod|END_ENTITY	MDMA -LRB- `` Ecstasy '' -RRB- suppresses the innate IFN-gamma response in vivo : a critical role for the anti-inflammatory cytokine IL-10 .
18655171	0	IFN-gamma	0,9	IL-10	111,116	IFN-gamma	IL-10	3458	3586	Gene	Gene	synergizes|amod|START_ENTITY synthase|nsubj|synergizes synthase|dobj|END_ENTITY	IFN-gamma synergizes with LPS to induce nitric_oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10 .
18713986	0	IFN-gamma	64,73	IL-10	30,35	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	axis|amod|START_ENTITY axis|dep|suppresses suppresses|nsubj|END_ENTITY	Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12 / IFN-gamma axis in lung-challenged aged mice .
18799001	0	IFN-gamma	74,83	IL-10	85,90	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	CpG Immunotherapy in Chenopodium album sensitized mice : The comparison of IFN-gamma , IL-10 and IgE responses in intranasal and subcutaneous administrations .
19266486	0	IFN-gamma	43,52	IL-10	0,5	IFN-gamma	IL-10	3458	3586	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells .
19535638	0	IFN-gamma	0,9	IL-10	33,38	IFN-gamma	IL-10	3458	3586	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|cells cells|nsubj|generation generation|nmod|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
20042578	0	IFN-gamma	64,73	IL-10	0,5	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	response|amod|START_ENTITY limits|dobj|response limits|nsubj|induction induction|compound|END_ENTITY	IL-10 induction by Bordetella_parapertussis limits a protective IFN-gamma response .
21591983	0	IFN-gamma	53,62	IL-10	40,45	IFN-gamma	IL-10	3458	3586	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
25272942	0	IFN-gamma	15,24	IL-10	38,43	IFN-gamma	IL-10	3458	3586	Gene	Gene	START_ENTITY|dep|IL-17 IL-17|dep|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
7636207	0	IFN-gamma	34,43	IL-10	14,19	IFN-gamma	IL-10	3458	3586	Gene	Gene	transcription|amod|START_ENTITY Inhibition|nmod|transcription Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes .
8015314	0	IFN-gamma	90,99	IL-10	130,135	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	release|amod|START_ENTITY production|dep|release production|compound|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8108955	0	IFN-gamma	24,33	IL-10	78,83	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|dep|involvement involvement|nmod|END_ENTITY	Defective production of IFN-gamma in neonatally tolerant mice : involvement of IL-10 .
8564698	0	IFN-gamma	45,54	IL-10	11,16	IFN-gamma	IL-10	3458	3586	Gene	Gene	production|amod|START_ENTITY antigen-induced|dobj|production antigen-induced|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of IL-10 on the mite antigen-induced IFN-gamma production by peripheral blood lymphocytes from individuals with bronchial_asthma -RSB- .
8608632	0	IFN-gamma	32,41	IL-10	44,49	IFN-gamma	IL-10	3458	3586	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-10 , IL-12 and transforming growth factor-beta -LRB- TGF-beta -RRB- mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid_arthritis -LRB- RA -RRB- .
8622992	0	IFN-gamma	42,51	IL-10	61,66	IFN-gamma	IL-10	3458	3586	Gene	Gene	interleukin|dep|START_ENTITY END_ENTITY|nsubj|interleukin	Comparative interleukin -LRB- IL-2 -RRB- / interferon IFN-gamma and IL-4 / IL-10 responses during acute infection of macaques inoculated with attenuated nef-truncated or pathogenic SICmac251 virus .
8757617	0	IFN-gamma	49,58	IL-10	38,43	IFN-gamma	IL-10	3458	3586	Gene	Gene	secreting|nmod|START_ENTITY secreting|dobj|END_ENTITY	IL-12 induces human T cells secreting IL-10 with IFN-gamma .
9328116	0	IFN-gamma	18,27	IL-10	53,58	IFN-gamma	IL-10	3458	3586	Gene	Gene	Interferon-gamma|appos|START_ENTITY regulates|nsubj|Interferon-gamma regulates|dobj|production production|nmod|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- regulates production of IL-10 and IL-12 in human_herpesvirus-6 _ -LRB- HHV-6 -RRB- - infected monocyte/macrophage lineage .
9670842	0	IFN-gamma	25,34	IL-10	82,87	IFN-gamma	IL-10	3458	3586	Gene	Gene	IL-4|amod|START_ENTITY levels|compound|IL-4 levels|nmod|levels levels|nmod|END_ENTITY	Elevated serum levels of IFN-gamma , IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating_diseases during the acute stage .
9743342	0	IFN-gamma	63,72	IL-10	119,124	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|dep|induction induction|nmod|END_ENTITY	Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10 : selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4 .
9767435	0	IFN-gamma	27,36	IL-10	11,16	IFN-gamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Endogenous IL-10 regulates IFN-gamma and IL-5 cytokine production and the granulomatous response in Schistosomiasis_mansoni-infected mice .
7947460	0	IFN-gamma	26,35	IL-12	0,5	IFN-gamma	IL-12	3458	64546(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4 + allergen-specific Th2 T cell clones .
18726352	0	IFN-gamma	20,29	IL-12_p40	63,72	IFN-gamma	IL-12 p40	15978(Tax:10090)	16160(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Promoting effect of IFN-gamma on the expression of LPS-induced IL-12_p40 and p35 mRNA in murine suppressor macrophages .
10229825	0	IFN-gamma	96,105	IL-18	0,5	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|nmod|START_ENTITY enhance|dobj|production use|xcomp|enhance use|nsubj|END_ENTITY	IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma .
10491411	0	IFN-gamma	14,23	IL-18	68,73	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	dependent|nsubj|START_ENTITY dependent|nmod|processing processing|nmod|precursor precursor|compound|END_ENTITY	IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor .
10508240	0	IFN-gamma	69,78	IL-18	98,103	IFN-gamma	IL-18	3458	3606	Gene	Gene	proliferation|nmod|START_ENTITY enhances|dobj|proliferation enhances|advcl|combined combined|nmod|END_ENTITY	IL-10 enhances NK cell proliferation , cytotoxicity and production of IFN-gamma when combined with IL-18 .
10653850	0	IFN-gamma	44,53	IL-18	22,27	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells .
10679096	0	IFN-gamma	101,110	IL-18	91,96	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	IL-12-independent Th1-type immune responses to respiratory viral_infection : requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes .
10760800	0	IFN-gamma	71,80	IL-18	28,33	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induction|nmod|production END_ENTITY|nmod|induction	The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit .
10878369	0	IFN-gamma	144,153	IL-18	0,5	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induction|nmod|production host|nmod|induction contributes|xcomp|host contributes|nsubj|END_ENTITY	IL-18 contributes to host resistance against infection with Cryptococcus_neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells .
10975835	0	IFN-gamma	0,9	IL-18	23,28	IFN-gamma	IL-18	3458	3606	Gene	Gene	up-regulates|amod|START_ENTITY up-regulates|dep|expression expression|compound|END_ENTITY	IFN-gamma up-regulates IL-18 gene expression via IFN_consensus_sequence-binding_protein and activator protein-1 elements in macrophages .
11046000	0	IFN-gamma	74,83	IL-18	24,29	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY induction|nmod|responses requirements|nmod|induction requirements|compound|END_ENTITY	Cutting edge : selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral_infection .
11076875	0	IFN-gamma	77,86	IL-18	0,5	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	manner|amod|START_ENTITY mice|nmod|manner induce|nmod|mice induce|nsubj|END_ENTITY	IL-18 and IL-12 induce intestinal_inflammation and fatty_liver in mice in an IFN-gamma dependent manner .
11466347	0	IFN-gamma	49,58	IL-18	120,125	IFN-gamma	IL-18	3458	3606	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|factor factor|nmod|induction induction|nmod|complex complex|amod|END_ENTITY	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex .
11529897	0	IFN-gamma	0,9	IL-18	36,41	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|amod|START_ENTITY production|nmod|stimulation stimulation|amod|END_ENTITY	IFN-gamma production in response to IL-18 or IL-12 stimulation by peripheral blood mononuclear cells of atopic patients .
11544324	0	IFN-gamma	18,27	IL-18	97,102	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY mediated|nsubjpass|production mediated|nmod|END_ENTITY	IL-12-independent IFN-gamma production by T cells in experimental Chagas ' _ disease is mediated by IL-18 .
11882913	0	IFN-gamma	87,96	IL-18	68,73	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|amod|START_ENTITY interaction|nmod|production interaction|nmod|effect effect|nmod|END_ENTITY	Essential role of ICAM-1 / LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC .
11960649	0	IFN-gamma	26,35	IL-18	0,5	IFN-gamma	IL-18	3458	3606	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	IL-18 is linked to raised IFN-gamma in multiple_sclerosis and is induced by activated CD4 -LRB- + -RRB- T cells via CD40-CD40 ligand interactions .
12023376	0	IFN-gamma	104,113	IL-18	0,5	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induction|nmod|production host|nmod|induction contributes|xcomp|host contributes|nsubj|END_ENTITY	IL-18 contributes to host resistance against infection with Pseudomonas_aeruginosa through induction of IFN-gamma production .
12040407	0	IFN-gamma	72,81	IL-18	56,61	IFN-gamma	IL-18	3458	3606	Gene	Gene	Production|compound|START_ENTITY END_ENTITY|nmod|Production	Asp -LRB- 126 -RRB- , Asp -LRB- 130 -RRB- and Asp -LRB- 134 -RRB- are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC .
12067307	0	IFN-gamma	12,21	IL-18	59,64	IFN-gamma	IL-18	3458	3606	Gene	Gene	Profiles|nmod|START_ENTITY Profiles|appos|IL-12 IL-12|dep|END_ENTITY	Profiles of IFN-gamma and its regulatory cytokines -LRB- IL-12 , IL-18 and IL-10 -RRB- in peripheral blood mononuclear cells from patients with multidrug-resistant_tuberculosis .
12193725	0	IFN-gamma	85,94	IL-18	0,5	IFN-gamma	IL-18	15978(Tax:10090)	29197(Tax:10116)	Gene	Gene	mastocytosis|nmod|START_ENTITY regulates|dobj|mastocytosis regulates|nsubj|END_ENTITY	IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella_spiralis_infection .
12370378	0	IFN-gamma	0,9	IL-18	153,158	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	IFN-gamma production from liver mononuclear cells of mice in burn_injury as well as in postburn bacterial_infection models and the therapeutic effect of IL-18 .
12559970	0	IFN-gamma	23,32	IL-18	47,52	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|LNK5E6 LNK5E6|compound|END_ENTITY	TGFbeta down-regulates IFN-gamma production in IL-18 treated NK cell line LNK5E6 .
15554077	0	IFN-gamma	38,47	IL-18	87,92	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nmod|effect effect|nmod|END_ENTITY	T helper 1 inhibitor TAK-603 inhibits IFN-gamma and IL-12 production with no effect on IL-18 : an observation in sarcoidosis patients .
15604417	0	IFN-gamma	62,71	IL-18	0,5	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	elevation|nmod|START_ENTITY accompanied|nmod|elevation atherosclerosis|acl|accompanied accelerates|dobj|atherosclerosis accelerates|nsubj|END_ENTITY	IL-18 accelerates atherosclerosis accompanied by elevation of IFN-gamma and CXCL16 expression independently of T cells .
15950732	0	IFN-gamma	51,60	IL-18	35,40	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|amod|START_ENTITY elicit|dobj|production END_ENTITY|xcomp|elicit	Cys74 and Cys163 are necessary for IL-18 to elicit IFN-gamma production from peripheral blood lymphoid mononuclear cells .
16212914	0	IFN-gamma	30,39	IL-18	56,61	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Analysis tissue expression of IFN-gamma in IL-12 and/or IL-18 gene ablated na ve mice .
16785519	0	IFN-gamma	51,60	IL-18	0,5	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	immunity|nmod|START_ENTITY innate|dobj|immunity innate|nsubj|bridges bridges|compound|END_ENTITY	IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway .
17404259	0	IFN-gamma	51,60	IL-18	34,39	IFN-gamma	IL-18	3458	3606	Gene	Gene	secretion|amod|START_ENTITY pathway|nmod|secretion pathway|compound|END_ENTITY	Profound enhancement of the IL-12 / IL-18 pathway of IFN-gamma secretion in human CD8 + memory T cell subsets via IL-15 .
17878377	0	IFN-gamma	44,53	IL-18	38,43	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	START_ENTITY|dep|regulate regulate|dobj|END_ENTITY	ASC/PYCARD and caspase-1 regulate the IL-18 / IFN-gamma axis during Anaplasma_phagocytophilum infection .
9548493	0	IFN-gamma	106,115	IL-18	0,5	IFN-gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inducing|dobj|production protects|advcl|inducing protects|nsubj|END_ENTITY	IL-18 protects mice against pulmonary_and_disseminated_infection with Cryptococcus_neoformans by inducing IFN-gamma production .
9558078	0	IFN-gamma	105,114	IL-18	130,135	IFN-gamma	IL-18	3458	3606	Gene	Gene	produce|dobj|START_ENTITY produce|nmod|END_ENTITY	Differential capacities of CD4 + , CD8 + , and CD4-CD8 - T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18 .
9759857	0	IFN-gamma	106,115	IL-18	19,24	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|amod|START_ENTITY IL-18|nmod|production synergism|nmod|IL-18 expression|dep|synergism expression|compound|END_ENTITY	IL-12 up-regulates IL-18 receptor expression on T cells , Th1 cells , and B cells : synergism with IL-18 for IFN-gamma production .
9759857	0	IFN-gamma	106,115	IL-18	96,101	IFN-gamma	IL-18	3458	3606	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	IL-12 up-regulates IL-18 receptor expression on T cells , Th1 cells , and B cells : synergism with IL-18 for IFN-gamma production .
10681439	0	IFN-gamma	104,113	IL-18_binding_protein	0,21	IFN-gamma	IL-18 binding protein	3458	10068	Gene	Gene	inhibition|nmod|START_ENTITY production|nmod|inhibition increases|dobj|production increases|nsubj|END_ENTITY	IL-18_binding_protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma .
11739524	0	IFN-gamma	63,72	IL-18_binding_protein	26,47	IFN-gamma	IL-18 binding protein	3458	10068	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and release of IL-18_binding_protein in response to IFN-gamma .
11859116	0	IFN-gamma	60,69	IL-18_binding_protein	23,44	IFN-gamma	IL-18 binding protein	3458	10068	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	IL-12 induces monocyte IL-18_binding_protein expression via IFN-gamma .
12482935	0	IFN-gamma	56,65	IL-18_binding_protein	16,37	IFN-gamma	IL-18 binding protein	15978(Tax:10090)	16068(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY promoter|acl|activation promoter|nmod|END_ENTITY	The promoter of IL-18_binding_protein : activation by an IFN-gamma - induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta .
8666424	0	IFN-gamma	27,36	IL-1_beta	49,58	IFN-gamma	IL-1 beta	3458	3553	Gene	Gene	START_ENTITY|dep|IL-4 IL-4|dep|END_ENTITY	Effect of human cytokines -LRB- IFN-gamma , TNF-alpha , IL-1_beta , IL-4 -RRB- on porcine endothelial cells : induction of MHC and adhesion molecules and functional significance of these changes .
11567773	0	IFN-gamma	60,69	IL-1beta	20,28	IFN-alpha	IL-1beta	396398(Tax:9031)	395196(Tax:9031)	Gene	Gene	TGF-beta4|amod|START_ENTITY TGF-beta4|compound|END_ENTITY	Adjuvant effects of IL-1beta , IL-2 , IL-8 , IL-15 , IFN-alpha , IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina .
15383953	0	IFN-gamma	68,77	IL-1beta	52,60	IFN-gamma	IL-1beta	3458	3553	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	-LSB- Evaluation of proinflammatory cytokine -LRB- TNF-alpha , IL-1beta , IL-6 , IFN-gamma -RRB- concentrations in serum and cerebrospinal fluid of patients with neuroborreliosis -RSB- .
16263000	0	IFN-gamma	114,123	IL-1beta	102,110	IFN-gamma	IL-1beta	3458	3553	Gene	Gene	assay|amod|START_ENTITY END_ENTITY|nmod|assay	Polymorphism in IL1B : IL1B-511 association with tuberculosis and decreased lipopolysaccharide-induced IL-1beta in IFN-gamma primed ex-vivo whole blood assay .
17786499	0	IFN-gamma	92,101	IL-1beta	71,79	IFN-gamma	IL-1beta	25712(Tax:10116)	24494(Tax:10116)	Gene	Gene	bFGF|appos|START_ENTITY bFGF|compound|END_ENTITY	Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta , TNF-alpha , IFN-gamma , TGF-beta , bFGF , and PDGF in rat 's gingiva .
10714558	0	IFN-gamma	112,121	IL-2	35,39	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	amounts|nmod|START_ENTITY inducing|dobj|amounts enhances|advcl|inducing enhances|nsubj|Interleukin-18 Interleukin-18|nmod|combination combination|nmod|END_ENTITY	Interleukin-18 in combination with IL-2 enhances natural killer cell activity without inducing large amounts of IFN-gamma in vivo .
11712854	0	IFN-gamma	133,142	IL-2	144,148	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|appos|production production|amod|END_ENTITY	HLA-DQ6 transgenic_mice resistance to experimental autoimmune_myasthenia_gravis is linked to reduced acetylcholine receptor-specific IFN-gamma , IL-2 and IL-10 production .
11745353	0	IFN-gamma	32,41	IL-2	83,87	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY secrete|dobj|levels secrete|advcl|administration administration|nmod|END_ENTITY	NK cells secrete high levels of IFN-gamma in response to in vivo administration of IL-2 .
12444145	0	IFN-gamma	31,40	IL-2	41,45	IFN-gamma	IL-2	3458	3558	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
1531996	0	IFN-gamma	57,66	IL-2	69,73	IFN-gamma	IL-2	3458	3558	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Preferential messenger RNA expression of Th1-type cells -LRB- IFN-gamma + , IL-2 + -RRB- in classical delayed-type -LRB- tuberculin -RRB- hypersensitivity reactions in human skin .
15760388	0	IFN-gamma	0,9	IL-2	47,51	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	decreases|amod|START_ENTITY CTL|nsubj|decreases CTL|advcl|limiting limiting|dobj|production production|compound|END_ENTITY	IFN-gamma decreases CTL generation by limiting IL-2 production : A feedback loop controlling effector cell production .
15806975	0	IFN-gamma	68,77	IL-2	135,139	IFN-gamma	IL-2	3458	3558	Gene	Gene	interferon-gamma|appos|START_ENTITY efficacy|appos|interferon-gamma interleukin-2|nsubj|efficacy interleukin-2|dobj|levels levels|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
15951352	0	IFN-gamma	41,50	IL-2	0,4	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophages .
16256965	0	IFN-gamma	24,33	IL-2	0,4	IFN-gamma	IL-2	3458	3558	Gene	Gene	affects|dobj|START_ENTITY affects|nsubj|absorption absorption|compound|END_ENTITY	IL-2 absorption affects IFN-gamma and IL-5 , but not IL-4 producing memory T cells in double color cytokine ELISPOT assays .
18776133	0	IFN-gamma	0,9	IL-2	19,23	IFN-gamma	IL-2	3458	3558	Gene	Gene	reverses|nsubj|START_ENTITY reverses|dobj|resistance resistance|amod|END_ENTITY	IFN-gamma reverses IL-2 - and IL-4-mediated T-cell steroid resistance .
1906383	0	IFN-gamma	94,103	IL-2	70,74	IFN-gamma	IL-2	3458	3558	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|compound|END_ENTITY	Effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- , tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes .
1907306	0	IFN-gamma	37,46	IL-2	32,36	IFN-gamma	IL-2	3458	3558	Gene	Gene	mRNA|amod|START_ENTITY expression|dep|mRNA expression|nmod|END_ENTITY	Restricted T cell expression of IL-2 / IFN-gamma mRNA in human inflammatory_disease .
2110548	0	IFN-gamma	6,15	IL-2	29,33	IFN-gamma	IL-2	3458	3558	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|receptors receptors|compound|END_ENTITY	Human IFN-gamma up-regulates IL-2 receptors in mitogen-activated T lymphocytes .
7774054	0	IFN-gamma	51,60	IL-2	18,22	IFN-gamma	IL-2	3458	3558	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of IL-2 , IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- mRNA using liver biopsies at different phases of acute exacerbation of chronic_hepatitis_B .
8015314	0	IFN-gamma	90,99	IL-2	85,89	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	release|amod|START_ENTITY production|dep|release production|amod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8097754	0	IFN-gamma	0,9	IL-2	71,75	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	dependent|dep|START_ENTITY dependent|advmod|END_ENTITY	IFN-gamma , but not IL-4 , synthesis by antigen-primed murine T cells is IL-2 dependent .
8622992	0	IFN-gamma	42,51	IL-2	25,29	IFN-gamma	IL-2	3458	3558	Gene	Gene	interleukin|dep|START_ENTITY interleukin|appos|END_ENTITY	Comparative interleukin -LRB- IL-2 -RRB- / interferon IFN-gamma and IL-4 / IL-10 responses during acute infection of macaques inoculated with attenuated nef-truncated or pathogenic SICmac251 virus .
8786299	0	IFN-gamma	80,89	IL-2	10,14	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	enhance|nmod|START_ENTITY enhance|nsubj|END_ENTITY	High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4 + T cells for IFN-gamma but have differential effects on priming for IL-4 .
8948120	0	IFN-gamma	77,86	IL-2	138,142	IFN-gamma	IL-2	3458	3558	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression metabolites|nmod|regulation metabolites|nmod|histamine histamine|nmod|cells cells|nmod|stimulation stimulation|compound|END_ENTITY	The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation .
9590250	0	IFN-gamma	37,46	IL-2	104,108	IFN-gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|dep|requirements requirements|nmod|END_ENTITY	CD4 + and CD8 + T cell interactions in IFN-gamma and IL-4 responses to viral_infections : requirements for IL-2 .
9933441	0	IFN-gamma	29,38	IL-2	5,9	IFN-gamma	IL-2	3458	3558	Gene	Gene	Th1|appos|START_ENTITY Th1|dep|interferon-gamma interferon-gamma|compound|END_ENTITY	Th1 -LRB- IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- -RRB- and Th2 -LRB- IL-10 , IL-4 -RRB- cytokine production by peripheral blood mononuclear cells -LRB- PBMC -RRB- from patients with systemic_lupus_erythematosus -LRB- SLE -RRB- .
12759422	0	IFN-gamma	46,55	IL-21	0,5	IFN-gamma	IL-21	3458	59067	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells .
16951332	0	IFN-gamma	15,24	IL-21	0,5	IFN-gamma	IL-21	3458	59067	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression .
18497880	0	IFN-gamma	93,102	IL-23	87,92	IFN-gamma	IL-23	3458	51561	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn_disease via IL-23 / IFN-gamma axis .
20027291	0	IFN-gamma	109,118	IL-23	19,24	IFN-gamma	IL-23	3458	51561	Gene	Gene	induction|nmod|START_ENTITY allow|nmod|induction allow|nsubj|induced induced|amod|END_ENTITY	Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells .
20228197	0	IFN-gamma	14,23	IL-23	51,56	IFN-gamma	IL-23	15978(Tax:10090)	83430(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Cutting edge : IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis .
21515794	0	IFN-gamma	54,63	IL-23	34,39	IFN-gamma	IL-23	3458	51561	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|regulation regulation|nmod|END_ENTITY	Posttranscriptional regulation of IL-23 expression by IFN-gamma through tristetraprolin .
18199488	0	IFN-gamma	16,25	IL-24	0,5	IFN-gamma	IL-24	3458	11009	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	IL-24 modulates IFN-gamma expression in patients with tuberculosis .
2104898	2	IFN-gamma	177,186	IL-3	91,95	IFN-gamma	IL-3	15978(Tax:10090)	16187(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY masked|nmod|action END_ENTITY|acl:relcl|masked	Murine CTL clones produce IL-3 and GM-CSF , the activity of which is masked by the inhibitory action of secreted IFN-gamma .
2971726	2	IFN-gamma	65,74	IL-3	146,150	IFN-gamma	IL-3	15978(Tax:10090)	16187(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|cells cells|acl|stimulated stimulated|nmod|END_ENTITY	IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3 , IL-4 , or granulocyte-macrophage colony-stimulating factor .
8807498	0	IFN-gamma	0,9	IL-3	30,34	IFN-gamma	IL-3	15978(Tax:10090)	16187(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	IFN-gamma in combination with IL-3 accelerates platelet recovery in mice with 5-fluorouracil-induced marrow_aplasia .
10454344	0	IFN-gamma	146,155	IL-4	176,180	IFN-gamma	IL-4	281237(Tax:9913)	280824(Tax:9913)	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|advcl|has has|nsubj|END_ENTITY	Comparative effects of interleukin-12 and interleukin-4 on cytokine responses by antigen-stimulated memory CD4 + T cells of cattle : IL-12 enhances IFN-gamma production , whereas IL-4 has marginal effects on cytokine expression .
10482358	0	IFN-gamma	71,80	IL-4	161,165	IFN-gamma	IL-4	3458	3565	Gene	Gene	gene|amod|START_ENTITY regions|nmod|gene Hypomethylation|nmod|regions essential|nsubj|Hypomethylation essential|nmod|transcription transcription|nmod|cells cells|acl|cultured cultured|nmod|END_ENTITY	Hypomethylation of the proximal and intronic regulatory regions of the IFN-gamma gene is not essential for its transcription by naive CD4 + T cells cultured with IL-4 .
10604994	0	IFN-gamma	57,66	IL-4	23,27	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells .
10605032	0	IFN-gamma	114,123	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY antagonize|nmod|role antagonize|nsubj|END_ENTITY	IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia_virus infection with a limited role of IFN-gamma and nitric_oxide synthetase 2 .
10706694	0	IFN-gamma	98,107	IL-4	24,28	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY default|dobj|production leads|xcomp|default leads|nsubj|Dominance Dominance|nmod|differentiation differentiation|amod|IL-12 IL-12|nmod|END_ENTITY	Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma : failure to down-regulate IL-12 receptor beta 2-chain expression .
11033016	0	IFN-gamma	42,51	IL-4	53,57	IFN-gamma	IL-4	25712(Tax:10116)	287287(Tax:10116)	Gene	Gene	analysis|nmod|START_ENTITY T-cells|nsubj|analysis T-cells|nsubj|END_ENTITY	Flow cytometric analysis of intracellular IFN-gamma , IL-4 and IL-10 in CD3 -LRB- + -RRB- 4 -LRB- + -RRB- T-cells from rat spleen .
11067899	0	IFN-gamma	0,9	IL-4	77,81	IFN-gamma	IL-4	3458	3565	Gene	Gene	down-regulate|nsubj|START_ENTITY down-regulate|dobj|expression expression|compound|END_ENTITY	IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4-induced IL-4 receptor gene expression .
11160342	0	IFN-gamma	49,58	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppressing|dobj|production eosinophilia|advcl|suppressing promotes|xcomp|eosinophilia promotes|nsubj|END_ENTITY	IL-4 promotes airway eosinophilia by suppressing IFN-gamma production : defining a novel role for IFN-gamma in the regulation of allergic_airway_inflammation .
11160342	0	IFN-gamma	97,106	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY defining|dobj|role promotes|parataxis|defining promotes|nsubj|END_ENTITY	IL-4 promotes airway eosinophilia by suppressing IFN-gamma production : defining a novel role for IFN-gamma in the regulation of allergic_airway_inflammation .
11180096	0	IFN-gamma	163,172	IL-4	0,4	IFN-gamma	IL-4	3458	287287(Tax:10116)	Gene	Gene	activated|nmod|START_ENTITY fibroblasts|acl|activated regulate|nmod|fibroblasts regulate|nsubj|END_ENTITY	IL-4 and IL-13 regulate the induction of indoleamine 2,3-dioxygenase activity and the control of Toxoplasma_gondii replication in human fibroblasts activated with IFN-gamma .
11359851	0	IFN-gamma	134,143	IL-4	129,133	IFN-gamma	IL-4	3458	3565	Gene	Gene	ratios|amod|START_ENTITY subset|dep|ratios subset|nmod|cells cells|nmod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11500833	0	IFN-gamma	134,143	IL-4	60,64	IFN-gamma	IL-4	3458	3565	Gene	Gene	production|amod|START_ENTITY control|dobj|production kinases|acl:relcl|control induces|dobj|kinases induces|ccomp|induces induces|dobj|signal signal|acl:relcl|triggers triggers|dobj|synthesis synthesis|compound|END_ENTITY	Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis , stronger TCR stimulation induces MAP kinases that control IFN-gamma production .
11777537	0	IFN-gamma	29,38	IL-4	0,4	IFN-gamma	IL-4	281237(Tax:9913)	280824(Tax:9913)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	IL-4 and IL-10 inhibition of IFN-gamma - and TNF-alpha-dependent nitric_oxide production from bovine mononuclear phagocytes exposed to Babesia_bovis merozoites .
11877032	0	IFN-gamma	49,58	IL-4	43,47	IFN-gamma	IL-4	3458	3565	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|nmod|expressions expressions|nmod|END_ENTITY	-LSB- A comparative study on the expressions of IL-4 , IFN-gamma and TNF-alpha in BMMNC of acute and chronic aplastic_anemia patients -RSB- .
11971011	0	IFN-gamma	138,147	IL-4	6,10	IFN-gamma	IL-4	15978(Tax:10090)	3565	Gene	Gene	antibodies|amod|START_ENTITY treated|nmod|antibodies mice|acl|treated cells|nmod|mice T|dobj|cells T|nsubj|production production|compound|END_ENTITY	Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4 -LRB- + -RRB- T cells in resistant mice treated once with anti-IL-12 or - IFN-gamma antibodies at the onset of infection with Leishmania_major instructs Th2 cell development , resulting in nonhealing lesions .
12055229	0	IFN-gamma	42,51	IL-4	124,128	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulates|advmod|START_ENTITY regulates|nmod|preventing preventing|dobj|effects effects|nmod|END_ENTITY	Role of IFN-gamma in Th1 differentiation : IFN-gamma regulates IL-18R_alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression .
12055229	0	IFN-gamma	8,17	IL-4	124,128	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|regulates regulates|nmod|preventing preventing|dobj|effects effects|nmod|END_ENTITY	Role of IFN-gamma in Th1 differentiation : IFN-gamma regulates IL-18R_alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression .
12405160	0	IFN-gamma	72,81	IL-4	67,71	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	paradigm|amod|START_ENTITY NK_1|parataxis|paradigm NK_1|dep|lymphocyte lymphocyte|nmod|END_ENTITY	NK_1 .1 + T cell : a two-faced lymphocyte in immune modulation of the IL-4 / IFN-gamma paradigm .
12479817	0	IFN-gamma	0,9	IL-4	20,24	IFN-gamma	IL-4	3458	3565	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 .
12637316	0	IFN-gamma	59,68	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY IL-2|dep|expression enhances|dobj|IL-2 enhances|nsubj|END_ENTITY	IL-4 synergistically enhances both IL-2 - _ and_IL-12-induced IFN-gamma expression in murine NK cells .
12702146	0	IFN-gamma	36,45	IL-4	60,64	IFN-gamma	IL-4	3458	3565	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Ultraviolet-B irradiation decreases IFN-gamma and increases IL-4 expression in psoriatic lesional skin in situ and in cultured dermal T cells derived from these lesions .
12954239	0	IFN-gamma	60,69	IL-4	94,98	IFN-gamma	IL-4	281237(Tax:9913)	280824(Tax:9913)	Gene	Gene	IL-1_alpha|dep|START_ENTITY pro-inflammatory|appos|IL-1_alpha pro-inflammatory|appos|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
15059068	0	IFN-gamma	19,28	IL-4	14,18	IFN-gamma	IL-4	3458	3565	Gene	Gene	producing|nsubj|START_ENTITY END_ENTITY|parataxis|producing	Intracellular IL-4 / IFN-gamma producing peripheral T lymphocyte subsets in B cell non-Hodgkin 's _ lymphoma patients .
1531844	0	IFN-gamma	52,61	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY induced|nmod|IL-2 expression|acl|induced cytokine|dobj|expression cytokine|nsubj|suppresses suppresses|compound|END_ENTITY	IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages .
15661890	0	IFN-gamma	0,9	IL-4	80,84	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	suppresses|amod|START_ENTITY STAT6|nsubj|suppresses STAT6|advcl|inhibiting inhibiting|nmod|receptor receptor|compound|END_ENTITY	IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor .
16237058	0	IFN-gamma	44,53	IL-4	59,63	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY produce|nmod|stimulation stimulation|compound|END_ENTITY	Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation .
1627494	0	IFN-gamma	55,64	IL-4	24,28	IFN-gamma	IL-4	3458	3565	Gene	Gene	synthesis|amod|START_ENTITY effects|nmod|synthesis effects|nmod|END_ENTITY	Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity .
16513426	0	IFN-gamma	30,39	IL-4	52,56	IFN-gamma	IL-4	3458	3565	Gene	Gene	IL-5|appos|START_ENTITY IL-5|appos|END_ENTITY	Evaluation of cytokines -LRB- MIG , IFN-gamma , TNF-alpha , IL-4 , IL-5 , and IL-10 -RRB- during the different evolutive phases of chagasic esophagopathy .
16621996	0	IFN-gamma	35,44	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY induces|nmod|production induces|nsubj|END_ENTITY	IL-4 induces in vivo production of IFN-gamma by NK and NKT cells .
17075267	0	IFN-gamma	80,89	IL-4	55,59	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|nmod|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
1904904	0	IFN-gamma	0,9	IL-4	19,23	IFN-gamma	IL-4	3458	3565	Gene	Gene	reverses|nsubj|START_ENTITY reverses|dobj|inhibition inhibition|compound|END_ENTITY	IFN-gamma reverses IL-4 inhibition of fetal thymus growth in organ culture .
19079171	0	IFN-gamma	123,132	IL-4	78,82	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Persistence of Entamoeba_histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-gamma .
2115545	0	IFN-gamma	124,133	IL-4	28,32	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	marrow-derived|nmod|START_ENTITY marrow-derived|nsubj|Induction Induction|nmod|expression expression|compound|END_ENTITY	Induction and regulation of IL-4 receptor expression on murine macrophage cell lines and bone marrow-derived macrophages by IFN-gamma .
2118480	0	IFN-gamma	97,106	IL-4	46,50	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY TNF-alpha|acl|inhibition enhancement|nmod|TNF-alpha enhancement|dep|Priming Priming|nmod|END_ENTITY	Priming the macrophage respiratory burst with IL-4 : enhancement with TNF-alpha but inhibition by IFN-gamma .
2136895	0	IFN-gamma	31,40	IL-4	0,4	IFN-gamma	IL-4	3458	3565	Gene	Gene	synthesis|nmod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures .
23259293	0	IFN-gamma	28,37	IL-4	22,26	IFN-gamma	IL-4	3458	3565	Gene	Gene	methylation|amod|START_ENTITY END_ENTITY|appos|methylation	-LSB- Comparative study of IL-4 , IFN-gamma gene methylation for the epigenetics of allergic_rhinitis in Xinjiang Uygur , Han people -RSB- .
24015634	0	IFN-gamma	23,32	IL-4	17,21	IFN-gamma	IL-4	3458	3565	Gene	Gene	IL-32|compound|START_ENTITY END_ENTITY|appos|IL-32	-LSB- Levels of serum IL-4 , IFN-gamma , IL-32 in children with juvenile-onset recurrent respiratory_papillomatosis -RSB- .
2509562	0	IFN-gamma	99,108	IL-4	0,4	IFN-gamma	IL-4	3458	3565	Gene	Gene	mediated|nmod|START_ENTITY monocytes|acl|mediated production|nmod|monocytes inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma .
25272942	0	IFN-gamma	15,24	IL-4	32,36	IFN-gamma	IL-4	3458	3565	Gene	Gene	START_ENTITY|dep|IL-17 IL-17|compound|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
2844892	0	IFN-gamma	0,9	IL-4	159,163	IFN-gamma	IL-4	3458	3565	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|ccomp|lymphocytes lymphocytes|advcl|altering altering|dobj|binding binding|nmod|END_ENTITY	IFN-gamma and prostaglandin_E2 inhibit IL-4-induced expression of Fc epsilon R2/CD23 on B lymphocytes through different mechanisms without altering binding of IL-4 to its receptor .
7530038	0	IFN-gamma	37,46	IL-4	32,36	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	profile|amod|START_ENTITY establishment|dep|profile establishment|nmod|END_ENTITY	Rapid establishment of a stable IL-4 / IFN-gamma production profile in the antigen-specific CD4 + T cell response to protein immunization .
7542576	0	IFN-gamma	84,93	IL-4	96,100	IFN-gamma	IL-4	3458	3565	Gene	Gene	interferon-gamma|appos|START_ENTITY expressing|dobj|interferon-gamma present|advcl|expressing present|nsubj|factor-beta factor-beta|compound|END_ENTITY	High numbers of autoantigen-reactive mononuclear cells expressing interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- are present in cord blood .
7722306	0	IFN-gamma	63,72	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY factor|acl:relcl|binds activates|dobj|factor activates|nsubj|END_ENTITY	IL-4 activates a latent DNA-binding factor that binds a shared IFN-gamma and IL-4 response element present in the germ-line gamma 1 Ig promoter .
7751657	0	IFN-gamma	49,58	IL-4	27,31	IFN-gamma	IL-4	3458	3565	Gene	Gene	response|amod|START_ENTITY effects|nmod|response effects|nmod|END_ENTITY	Down-regulating effects of IL-4 and IL-10 on the IFN-gamma response in atopic_dermatitis .
7774059	0	IFN-gamma	43,52	IL-4	16,20	IFN-gamma	IL-4	3458	3565	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Increased IL-2 , IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- in steroid-sensitive nephrotic_syndrome .
7902377	1	IFN-gamma	134,143	IL-4	111,115	IFN-gamma	IL-4	3458	3565	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison with IL-4 and modulation by IFN-gamma or IL-10 .
7994903	0	IFN-gamma	43,52	IL-4	55,59	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Cross-regulatory role of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and IL-10 in schistosome egg granuloma formation : in vivo regulation of Th activity and inflammation .
8004818	0	IFN-gamma	93,102	IL-4	69,73	IFN-gamma	IL-4	3458	3565	Gene	Gene	interferon-gamma|appos|START_ENTITY END_ENTITY|appos|interferon-gamma	Growth and major histocompatibility antigen expression regulation by IL-4 , interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- on human renal_cell_carcinoma .
8015314	0	IFN-gamma	90,99	IL-4	125,129	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8565269	0	IFN-gamma	95,104	IL-4	48,52	IFN-gamma	IL-4	3458	3565	Gene	Gene	expression|appos|START_ENTITY expression|nmod|mRNA mRNA|nmod|END_ENTITY	Differential spontaneous expression of mRNA for IL-4 , IL-10 , IL-13 , IL-2 and interferon-gamma -LRB- IFN-gamma -RRB- in peripheral blood mononuclear cells -LRB- PBMC -RRB- from atopic patients .
8621932	0	IFN-gamma	45,54	IL-4	19,23	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation by IL-4 and up-regulation by IFN-gamma of mast cell induction from mouse spleen cells .
8805678	0	IFN-gamma	106,115	IL-4	145,149	IFN-gamma	IL-4	3458	3565	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|production production|compound|END_ENTITY	Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals : decreased IFN-gamma in the presence of preserved IL-4 production .
8805678	0	IFN-gamma	106,115	IL-4	24,28	IFN-gamma	IL-4	3458	3565	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|production production|compound|END_ENTITY	Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals : decreased IFN-gamma in the presence of preserved IL-4 production .
8921430	0	IFN-gamma	79,88	IL-4	67,71	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes .
8943375	0	IFN-gamma	94,103	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY pathogen|nmod|mice ameliorate|nmod|pathogen ameliorate|nsubj|neutralization neutralization|compound|END_ENTITY	IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice .
9182905	0	IFN-gamma	64,73	IL-4	37,41	IFN-gamma	IL-4	3458	3565	Gene	Gene	modulation|appos|START_ENTITY modulation|nmod|histamine histamine|nmod|END_ENTITY	Different modulation by histamine of IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- release according to the phenotype of human Th0 , Th1 and Th2 clones .
9328118	0	IFN-gamma	51,60	IL-4	24,28	IFN-gamma	IL-4	281237(Tax:9913)	280824(Tax:9913)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Antagonistic effects of IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- on inducible nitric_oxide synthase expression in bovine macrophages exposed to gram-positive bacteria .
9394788	0	IFN-gamma	123,132	IL-4	151,155	IFN-gamma	IL-4	3458	3565	Gene	Gene	predominates|amod|START_ENTITY predominates|nmod|secretion secretion|compound|END_ENTITY	Compartmentalization of antigen specific cytokine responses to the central nervous system in CNS borreliosis : secretion of IFN-gamma predominates over IL-4 secretion in response to outer surface proteins of Lyme_disease Borrelia spirochetes .
9550426	0	IFN-gamma	0,9	IL-4	93,97	IFN-gamma	IL-4	3458	3565	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	IFN-gamma and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes .
9619449	0	IFN-gamma	102,111	IL-4	117,121	IFN-gamma	IL-4	3458	3565	Gene	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses .
9683262	0	IFN-gamma	81,90	IL-4	0,4	IFN-gamma	IL-4	3458	3565	Gene	Gene	gene|amod|START_ENTITY region|nmod|gene hypomethylation|nmod|region inhibit|dobj|hypomethylation inhibit|nsubj|END_ENTITY	IL-4 and prostaglandin_E2 inhibit hypomethylation of the 5 ' regulatory region of IFN-gamma gene during differentiation of naive CD4 + T cells .
9712058	0	IFN-gamma	109,118	IL-4	0,4	IFN-gamma	IL-4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	+|amod|START_ENTITY analysis|nmod|+ lymphocytes|nsubj|analysis protects|parataxis|lymphocytes protects|nsubj|END_ENTITY	IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium_parvum infection : analysis of CD4 + alpha beta + IFN-gamma + and CD4 + alpha beta + IL-4 + lymphocytes in gut-associated lymphoid tissue during resolution of infection .
10582110	0	IFN-gamma	36,45	IL-5	30,34	IFN-gamma	IL-5	3458	3567	Gene	Gene	IL-8|appos|START_ENTITY IL-8|compound|END_ENTITY	Increased expression of IL-4 , IL-5 , IFN-gamma , IL-6 , IL-8 , and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis .
21744329	0	IFN-gamma	85,94	IL-5	61,65	IFN-gamma	IL-5	3458	3567	Gene	Gene	IL-13|dep|START_ENTITY IL-13|compound|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
10582110	0	IFN-gamma	36,45	IL-6	47,51	IFN-gamma	IL-6	3458	3569	Gene	Gene	IL-8|appos|START_ENTITY IL-8|appos|END_ENTITY	Increased expression of IL-4 , IL-5 , IFN-gamma , IL-6 , IL-8 , and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis .
11529906	0	IFN-gamma	75,84	IL-6	34,38	IFN-gamma	IL-6	3458	3569	Gene	Gene	cytokines|appos|START_ENTITY cytokines|amod|cytokines cytokines|dep|IL-17 IL-17|appos|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
11916128	0	IFN-gamma	75,84	IL-6	18,22	IFN-gamma	IL-6	3458	3569	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes .
12380642	0	IFN-gamma	48,57	IL-6	92,96	IFN-gamma	IL-6	3458	3569	Gene	Gene	effects|nmod|START_ENTITY effects|dep|increase increase|nmod|secretion secretion|compound|END_ENTITY	Contrasting effects of long-term treatment with IFN-gamma in endothelial cells : increase in IL-6 secretion versus decrease in IL-8 secretion , NF-kappa_B , and AP-1 activation .
12471139	0	IFN-gamma	0,9	IL-6	20,24	IFN-gamma	IL-6	3458	3569	Gene	Gene	amplifies|nsubj|START_ENTITY amplifies|dobj|responses responses|compound|END_ENTITY	IFN-gamma amplifies IL-6 and IL-8 responses by airway epithelial-like cells via indoleamine 2,3-dioxygenase .
12954239	0	IFN-gamma	60,69	IL-6	43,47	IFN-gamma	IL-6	281237(Tax:9913)	517016(Tax:9913)	Gene	Gene	IL-1_alpha|dep|START_ENTITY IL-1_alpha|dep|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
15935883	0	IFN-gamma	40,49	IL-6	0,4	IFN-gamma	IL-6	3458	3569	Gene	Gene	production|amod|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
16258194	0	IFN-gamma	27,36	IL-6	38,42	IFN-gamma	IL-6	3458	3569	Gene	Gene	IL-17|appos|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16428073	0	IFN-gamma	135,144	IL-6	146,150	IFN-gamma	IL-6	15978(Tax:10090)	16193(Tax:10090)	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	In vitro and in vivo effects of mercuric_chloride on thymic endocrine activity , NK and NKT cell cytotoxicity , cytokine profiles -LRB- IL-2 , IFN-gamma , IL-6 -RRB- : role of the nitric_oxide-L-arginine pathway .
18600325	0	IFN-gamma	68,77	IL-6	44,48	IFN-gamma	IL-6	3458	3569	Gene	Gene	cytokines|appos|START_ENTITY cytokines|appos|IL-17 IL-17|dep|END_ENTITY	Profile of Th17 cytokines -LRB- IL-17 , TGF-beta , IL-6 -RRB- and Th1 cytokine -LRB- IFN-gamma -RRB- in patients with immune_thrombocytopenic_purpura .
19050105	0	IFN-gamma	0,9	IL-6	50,54	IFN-gamma	IL-6	15978(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|acl|regulated regulated|nmod|signal signal|compound|END_ENTITY	IFN-gamma expression in CD8 + T cells regulated by IL-6 signal is involved in superantigen-mediated CD4 + T cell death .
1918983	0	IFN-gamma	37,46	IL-6	0,4	IFN-gamma	IL-6	3458	3569	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	IL-6 and IL-6 receptor modulation by IFN-gamma and tumor necrosis factor-alpha in human monocytic cell line -LRB- THP-1 -RRB- .
19225954	0	IFN-gamma	103,112	IL-6	27,31	IFN-gamma	IL-6	3458	3569	Gene	Gene	synthesis|amod|START_ENTITY restoration|nmod|synthesis uninfluenced|nmod|restoration uninfluenced|nsubjpass|PMBC-derived PMBC-derived|amod|END_ENTITY	Postoperative PMBC-derived IL-6 and TNF-alpha-release is uninfluenced by IL-12-mediated restoration of IFN-gamma synthesis .
19497133	0	IFN-gamma	46,55	IL-6	77,81	IFN-gamma	IL-6	3458	3569	Gene	Gene	transduction|amod|START_ENTITY baseline|nmod|transduction baseline|nmod|END_ENTITY	Differential baseline and response profile to IFN-gamma gene transduction of IL-6 / IL-6 receptor-alpha secretion discriminate primary_tumors versus bone marrow metastases of nasopharyngeal_carcinomas in culture .
19497133	0	IFN-gamma	46,55	IL-6	82,86	IFN-gamma	IL-6	3458	3569	Gene	Gene	transduction|amod|START_ENTITY baseline|nmod|transduction baseline|parataxis|secretion secretion|nsubj|receptor-alpha receptor-alpha|compound|END_ENTITY	Differential baseline and response profile to IFN-gamma gene transduction of IL-6 / IL-6 receptor-alpha secretion discriminate primary_tumors versus bone marrow metastases of nasopharyngeal_carcinomas in culture .
21591983	0	IFN-gamma	53,62	IL-6	47,51	IFN-gamma	IL-6	3458	3569	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
21744329	0	IFN-gamma	85,94	IL-6	67,71	IFN-gamma	IL-6	3458	3569	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
7880401	0	IFN-gamma	18,27	IL-6	48,52	IFN-gamma	IL-6	3458	3569	Gene	Gene	Interferon-gamma|appos|START_ENTITY END_ENTITY|nsubj|Interferon-gamma	Interferon-gamma -LRB- IFN-gamma -RRB- and interleukin-6 -LRB- IL-6 -RRB- in peritoneal fluid and macrophage-conditioned media of women with endometriosis .
8543806	0	IFN-gamma	0,9	IL-6	19,23	IFN-gamma	IL-6	15978(Tax:10090)	16193(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|secretion secretion|amod|END_ENTITY	IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides .
9661265	0	IFN-gamma	50,59	IL-6	33,37	IFN-gamma	IL-6	396991(Tax:9823)	100628202	Gene	Gene	TNF-alpha|compound|START_ENTITY END_ENTITY|dep|TNF-alpha	Evaluation of various cytokines -LRB- IL-6 , IFN-alpha , IFN-gamma , TNF-alpha -RRB- as markers for acute bacterial_infection in swine -- a possible role for serum interleukin-6 .
9893032	0	IFN-gamma	6,15	IL-6	0,4	IFN-gamma	IL-6	25712(Tax:10116)	24498(Tax:10116)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|appos|production	IL-6 , IFN-gamma and TNF-alpha production by liver-associated T cells and acute_liver_injury in rats administered concanavalin A .
8568231	0	IFN-gamma	48,57	IL-7	0,4	IFN-gamma	IL-7	3458	3574	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms .
16258194	0	IFN-gamma	27,36	IL-8	44,48	IFN-gamma	IL-8	3458	3576	Gene	Gene	IL-17|appos|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
10376977	0	IFN-gamma	51,60	IRF-1	103,108	IFN-gamma	IRF-1	3458	3659	Gene	Gene	lines|nmod|START_ENTITY response|nmod|lines associated|nsubjpass|response associated|nmod|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Cytotoxic response of ovarian_cancer cell lines to IFN-gamma is associated with sustained induction of IRF-1 and p21 mRNA .
10882409	0	IFN-gamma	0,9	IRF-1	86,91	IFN-gamma	IRF-1	15978(Tax:10090)	16362(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|modulation modulation|compound|END_ENTITY	IFN-gamma and IL-4 differently regulate inducible_NO_synthase gene expression through IRF-1 modulation .
12479817	0	IFN-gamma	0,9	IRF-1	40,45	IFN-gamma	IRF-1	3458	3659	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 .
12584735	0	IFN-gamma	31,40	IRF-1	8,13	IFN-gamma	IRF-1	3458	3659	Gene	Gene	enhancement|amod|START_ENTITY Role|nmod|enhancement Role|nmod|END_ENTITY	Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN_renal_cell_carcinoma cells .
15511228	0	IFN-gamma	0,9	IRF-1	51,56	IFN-gamma	IRF-1	3458	3659	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	IFN-gamma enhances TRAIL-induced apoptosis through IRF-1 .
15871905	0	IFN-gamma	122,131	IRF-1	0,5	IFN-gamma	IRF-1	15978(Tax:10090)	16362(Tax:10090)	Gene	Gene	bind|nmod|START_ENTITY END_ENTITY|dep|bind	IRF-1 and NF-kappaB_p50 / cRel bind to distinct regions of the proximal murine IL-12_p35 promoter during costimulation with IFN-gamma and LPS .
15907481	0	IFN-gamma	39,48	IRF-1	0,5	IFN-gamma	IRF-1	15978(Tax:10090)	16362(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY mediates|nmod|expression mediates|nsubj|END_ENTITY	IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome .
1902147	0	IFN-gamma	0,9	IgG2a	32,37	IFN-gamma	IgG2a	15978(Tax:10090)	668478(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells : implications for the role of IFN-gamma in class switching .
1902147	0	IFN-gamma	119,128	IgG2a	32,37	IFN-gamma	IgG2a	15978(Tax:10090)	668478(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY implications|nmod|role secretion|dep|implications secretion|nmod|END_ENTITY	IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells : implications for the role of IFN-gamma in class switching .
3127461	0	IFN-gamma	0,9	IgG2a	21,26	IFN-gamma	IgG2a	15978(Tax:10090)	668478(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide .
11164459	0	IFN-gamma	18,27	Interferon-gamma	0,16	IFN-gamma	Interferon-gamma	3458	3458	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- levels finally become stable with increasing age as revealed by using an ELISA corresponding to the bioactivity .
3125740	0	IFN-gamma	18,27	Interferon-gamma	0,16	IFN-gamma	Interferon-gamma	3458	3458	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- as in vitro enhancing factor of peritoneal macrophage defective bactericidal activity during continuous_ambulatory_peritoneal_dialysis -LRB- CAPD -RRB- .
10452631	0	IFN-gamma	18,27	Interferon_gamma	0,16	IFN-gamma	Interferon gamma	3458	3458	Gene	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Interferon_gamma -LRB- IFN-gamma -RRB- deficiency in generalized Epstein-Barr_virus infection with interstitial lymphoid and granulomatous_pneumonia , focal cerebral_lesions , and genital ulcers : remission following IFN-gamma substitution therapy .
24528037	0	IFN-gamma	104,113	Interleukin-7	0,13	IFN-gamma	Interleukin-7	15978(Tax:10090)	16196(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY enhances|nmod|induction enhances|nsubj|END_ENTITY	Interleukin-7 enhances the in vivo anti-tumor activity of tumor-reactive CD8 + T cells with induction of IFN-gamma in a murine breast_cancer model .
7499845	0	IFN-gamma	127,136	JAK2	55,59	IFN-gamma	JAK2	15978(Tax:10090)	16452(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
7499845	0	IFN-gamma	18,27	JAK2	55,59	IFN-gamma	JAK2	15978(Tax:10090)	16452(Tax:10090)	Gene	Gene	sites|amod|START_ENTITY Identification|nmod|sites Identification|nmod|END_ENTITY	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
15742156	0	IFN-gamma	82,91	K-12	29,33	IFN-gamma	K-12	3458	3859	Gene	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|END_ENTITY	Expression of the CD7 ligand K-12 in human thymic epithelial cells : regulation by IFN-gamma .
19812202	0	IFN-gamma	58,67	LL-37	27,32	IFN-gamma	LL-37	3458	820	Gene	Gene	effects|nmod|START_ENTITY modulates|dobj|effects modulates|nsubj|END_ENTITY	Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs .
21591983	0	IFN-gamma	53,62	MBL	64,67	IFN-gamma	MBL	3458	50639	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
10496322	0	IFN-gamma	60,69	MCP-2	37,42	IFN-gamma	MCP-2	3458	6355	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Transcriptional control of the human MCP-2 gene promoter by IFN-gamma and IL-1beta in connective tissue cells .
20470822	0	IFN-gamma	0,9	MCP-2	26,31	IFN-gamma	MCP-2	3458	6355	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	IFN-gamma , but not IP-10 , MCP-2 or IL-2 response to RD1 selected peptides associates to active_tuberculosis .
21471448	0	IFN-gamma	16,25	MEKK3	0,5	IFN-gamma	MEKK3	15978(Tax:10090)	26406(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades .
10403908	0	IFN-gamma	79,88	MHC	23,26	IFN-gamma	MHC	3458	3133	Gene	Gene	expression|appos|START_ENTITY expression|nmod|molecules molecules|compound|END_ENTITY	Impaired expression of MHC class II molecules in response to interferon-gamma -LRB- IFN-gamma -RRB- on human thymoma neoplastic epithelial cells .
12538455	0	IFN-gamma	9,18	MHC	33,36	IFN-gamma	MHC	3458	3133	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant_melanoma .
9916700	0	IFN-gamma	0,9	MHC	25,28	IFN-gamma	MHC	3458	3133	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	IFN-gamma down-regulates MHC expression and antigen processing in a human B cell line .
17911618	0	IFN-gamma	32,41	MHC2TA	52,58	IFN-gamma	MHC2TA	3458	4261	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal_melanoma .
11972057	0	IFN-gamma	76,85	MIP-1beta	12,21	IFN-gamma	MIP-1beta	15978(Tax:10090)	20303(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	MIP-1alpha , MIP-1beta , RANTES , and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines .
1904900	0	IFN-gamma	45,54	Manganese_superoxide_dismutase	0,30	IFN-gamma	Manganese superoxide dismutase	3458	6648	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Manganese_superoxide_dismutase is induced by IFN-gamma in multiple cell types .
10227974	0	IFN-gamma	50,59	NF-kappa_B	22,32	IFN-gamma	NF-kappa B	3458	4790	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	An essential role for NF-kappa_B in IL-18-induced IFN-gamma expression in KG-1 cells .
1624799	0	IFN-gamma	0,9	NF_kappa_B	42,52	IFN-gamma	NF kappa B	15978(Tax:10090)	18033(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	IFN-gamma and IL-2 cooperatively activate NF_kappa_B in murine peritoneal macrophages .
16760259	0	IFN-gamma	0,9	NHE3	39,43	IFN-gamma	NHE3	3458	6550	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1 .
17075267	0	IFN-gamma	80,89	PAR-2	0,5	IFN-gamma	PAR-2	15978(Tax:10090)	109447(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY cells|dobj|downregulation cells|nsubj|T T|compound|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
11342638	0	IFN-gamma	77,86	PKR	29,32	IFN-gamma	PKR	3458	5610	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	RNA-dependent protein kinase PKR is required for activation of NF-kappa_B by IFN-gamma in a STAT1-independent pathway .
20470822	0	IFN-gamma	0,9	RD1	52,55	IFN-gamma	RD1	3458	5158	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	IFN-gamma , but not IP-10 , MCP-2 or IL-2 response to RD1 selected peptides associates to active_tuberculosis .
17986321	0	IFN-gamma	89,98	S100A7	0,6	IFN-gamma	S100A7	3458	6278	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	S100A7 -LRB- Psoriasin -RRB- , highly expressed in ductal_carcinoma in situ -LRB- DCIS -RRB- , is regulated by IFN-gamma in mammary epithelial cells .
15560546	0	IFN-gamma	45,54	SLAM-associated_protein	5,28	IFN-gamma	SLAM-associated protein	3458	4068	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- The SLAM-associated_protein -LRB- SAP -RRB- regulates IFN-gamma expression in leprosy -RSB- .
11466347	0	IFN-gamma	49,58	STAT4	28,33	IFN-gamma	STAT4	3458	6775	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|END_ENTITY	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex .
15528362	0	IFN-gamma	44,53	STAT5	17,22	IFN-gamma	STAT5	3458	6776	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression .
15661890	0	IFN-gamma	0,9	STAT6	21,26	IFN-gamma	STAT6	15978(Tax:10090)	20852(Tax:10090)	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor .
7686934	0	IFN-gamma	39,48	Substance_P	0,11	IFN-gamma	Substance P	15978(Tax:10090)	21333(Tax:10090)	Gene	Gene	production|amod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Substance_P modulates antigen-induced , IFN-gamma production in murine Schistosomiasis mansoni .
10193415	0	IFN-gamma	70,79	TGF-beta	201,209	IFN-gamma	TGF-beta	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY effects|nmod|interferon-gamma effects|appos|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
11352993	0	IFN-gamma	117,126	TGF-beta	0,8	IFN-gamma	TGF-beta	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY opposing|dobj|effects increases|parataxis|opposing increases|nsubj|END_ENTITY	TGF-beta increases cholesterol efflux and ABC-1 expression in macrophage-derived foam cells : opposing the effects of IFN-gamma .
11557514	0	IFN-gamma	33,42	TGF-beta	0,8	IFN-gamma	TGF-beta	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	TGF-beta and IL-10 regulation of IFN-gamma produced in Th2-type schistosome granulomas requires IL-12 .
12788525	0	IFN-gamma	0,9	TGF-beta	49,57	IFN-gamma	TGF-beta	3458	7040	Gene	Gene	fails|nsubj|START_ENTITY fails|xcomp|antagonize antagonize|dobj|effect effect|nmod|END_ENTITY	IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts .
16644489	0	IFN-gamma	14,23	TGF-beta	62,70	IFN-gamma	TGF-beta	3458	7040	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Human NK cell IFN-gamma production is regulated by endogenous TGF-beta .
17125875	0	IFN-gamma	0,9	TGF-beta	34,42	IFN-gamma	TGF-beta	3458	7040	Gene	Gene	abrogates|nsubj|START_ENTITY abrogates|dobj|signaling signaling|amod|END_ENTITY	IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads .
18340648	0	IFN-gamma	100,109	TGF-beta	58,66	IFN-gamma	TGF-beta	25712(Tax:10116)	59086(Tax:10116)	Gene	Gene	production|amod|START_ENTITY regulation|nmod|production regulation|amod|END_ENTITY	Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-beta and IL-10-mediated regulation of IFN-gamma production .
18466611	0	IFN-gamma	73,82	TGF-beta	112,120	IFN-gamma	TGF-beta	25712(Tax:10116)	59086(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY PECAM-1-gene-expression|acl|induced Decrease|nmod|PECAM-1-gene-expression reversed|nsubjpass|Decrease reversed|nmod|END_ENTITY	Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes .
18600325	0	IFN-gamma	68,77	TGF-beta	34,42	IFN-gamma	TGF-beta	3458	7040	Gene	Gene	cytokines|appos|START_ENTITY cytokines|appos|IL-17 IL-17|dep|END_ENTITY	Profile of Th17 cytokines -LRB- IL-17 , TGF-beta , IL-6 -RRB- and Th1 cytokine -LRB- IFN-gamma -RRB- in patients with immune_thrombocytopenic_purpura .
18768831	0	IFN-gamma	49,58	TGF-beta	0,8	IFN-gamma	TGF-beta	3458	7040	Gene	Gene	production|amod|START_ENTITY inhibit|dobj|production SMAD3|xcomp|inhibit SMAD3|nsubj|utilizes utilizes|amod|END_ENTITY	TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent_cellular_cytotoxicity in human NK cells .
19956908	0	IFN-gamma	50,59	TGF-beta	0,8	IFN-gamma	TGF-beta	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|superfamily superfamily|amod|END_ENTITY	TGF-beta superfamily enhances the antigen-induced IFN-gamma production by effector/memory CD8 + T cells .
9036950	0	IFN-gamma	20,29	TGF-beta	0,8	IFN-gamma	TGF-beta	3458	7040	Gene	Gene	induction|amod|START_ENTITY suppresses|dobj|induction suppresses|nsubj|END_ENTITY	TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class_II_transactivator messenger RNA expression .
9099937	0	IFN-gamma	46,55	TGF-beta	100,108	IFN-gamma	TGF-beta	25712(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Cellular mRNA expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- in rats nasally tolerized against experimental autoimmune_myasthenia_gravis -LRB- EAMG -RRB- .
9120265	0	IFN-gamma	24,33	TGF-beta	0,8	IFN-gamma	TGF-beta	3458	7040	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|amod|END_ENTITY	TGF-beta stimulates but IFN-gamma inhibits growth-related activation of locomotion of human B cells .
11991675	0	IFN-gamma	32,41	TGF-beta1	43,52	IFN-gamma	TGF-beta1	3458	7040	Gene	Gene	Production|nmod|START_ENTITY END_ENTITY|nsubj|Production	Production of IL-10 , TNF-alpha , IFN-gamma , TGF-beta1 by different populations of erythroid cells derived from human embryonal liver .
16237056	0	IFN-gamma	38,47	TGF-beta1	0,9	IFN-gamma	TGF-beta1	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4 + T cells through the protein tyrosine phosphatase Src_homology_region_2_domain-containing_phosphatase-1 .
16688597	0	IFN-gamma	48,57	TGF-beta1	22,31	IFN-gamma	TGF-beta1	3458	7040	Gene	Gene	levels|compound|START_ENTITY patients|nsubj|levels END_ENTITY|ccomp|patients	Increased intrathecal TGF-beta1 , but not IL-12 , IFN-gamma and IL-10 levels in Alzheimer 's _ disease patients .
19414763	0	IFN-gamma	94,103	TGF-beta1	27,36	IFN-gamma	TGF-beta1	3458	7040	Gene	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of membrane-bound TGF-beta1 and its regulation by IL-2-activated immune cell-derived IFN-gamma in head_and_neck_squamous_cell_carcinoma cell lines .
8608649	0	IFN-gamma	197,206	TGF-beta1	35,44	IFN-gamma	TGF-beta1	3458	7040	Gene	Gene	interferon-gamma|appos|START_ENTITY interrupted|nmod|interferon-gamma cell|acl:relcl|interrupted inhibition|nmod|cell Transforming_growth_factor-beta_1|dep|inhibition Transforming_growth_factor-beta_1|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- - mediated inhibition of glial cell proliferation and down-regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- are interrupted by interferon-gamma -LRB- IFN-gamma -RRB- .
12421979	0	IFN-gamma	17,26	TGF-beta_1	64,74	IFN-gamma	TGF-beta 1	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY Dysregulation|nmod|signaling pathways|nsubj|Dysregulation pathways|nmod|absence absence|nmod|END_ENTITY	Dysregulation of IFN-gamma signaling pathways in the absence of TGF-beta_1 .
12563723	0	IFN-gamma	12,21	TGF-beta_1	51,61	IFN-gamma	TGF-beta 1	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	hepatocytes|amod|START_ENTITY hepatocytes|nmod|END_ENTITY	-LSB- Effects of IFN-gamma gene-modified hepatocytes on TGF-beta_1 and its receptor in mice infected with Schistosoma_japonicum -RSB- .
12740179	0	IFN-gamma	21,30	TGF-beta_1	48,58	IFN-gamma	TGF-beta 1	574282(Tax:9544)	574135(Tax:9544)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Regulatory effect of IFN-gamma on expression of TGF-beta_1 , T beta R-II , and StAR in corpus luteum of pregnant rhesus_monkey .
15879087	0	IFN-gamma	47,56	TGF-beta_1	0,10	IFN-gamma	TGF-beta 1	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibit|dobj|expression uses|xcomp|inhibit uses|nsubj|END_ENTITY	TGF-beta_1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4 + T cells at priming and at recall : differential involvement of Stat4 and T-bet .
21591983	0	IFN-gamma	53,62	TGF-beta_1	28,38	IFN-gamma	TGF-beta 1	3458	7040	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
15728492	0	IFN-gamma	99,108	TNF	15,18	IFN-gamma	TNF	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY control|nmod|expression Involvement|nmod|control Involvement|nmod|END_ENTITY	Involvement of TNF and NF-kappa_B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages .
16465284	8	IFN-gamma	1408,1417	TNF	1418,1421	IFN-gamma	TNF	3458	7124	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	RT-PCR experiments and immunoprecipitation assays showed a late but marked increase in the expression of alpha1 , alpha2 , alpha3 , and beta1 chains after IFN-gamma + TNF treatment of LAN-5 cells , and only alpha1_and_beta1 chains upon RA induction .
21744329	0	IFN-gamma	85,94	TNF	80,83	IFN-gamma	TNF	3458	7124	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
7578980	0	IFN-gamma	0,9	TNF	52,55	IFN-gamma	TNF	3458	7124	Gene	Gene	priming|amod|START_ENTITY enhances|nsubj|priming enhances|dobj|production production|compound|END_ENTITY	IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability .
9521083	0	IFN-gamma	86,95	TNF	97,100	IFN-gamma	TNF	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-12|dep|START_ENTITY IL-12|dep|END_ENTITY	Small_bowel_enteropathy : role of intraepithelial lymphocytes and of cytokines -LRB- IL-12 , IFN-gamma , TNF -RRB- in the induction of epithelial cell death and renewal .
10030838	0	IFN-gamma	0,9	TNF-alpha	37,46	IFN-gamma	TNF-alpha	25712(Tax:10116)	24835(Tax:10116)	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|release release|nmod|END_ENTITY	IFN-gamma potentiates the release of TNF-alpha and MIP-1alpha by alveolar macrophages during allergic_reactions .
10193415	0	IFN-gamma	70,79	TNF-alpha	115,124	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
10505975	0	IFN-gamma	57,66	TNF-alpha	153,162	IFN-gamma	TNF-alpha	25712(Tax:10116)	24835(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|parataxis|affected affected|nmod|END_ENTITY	Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages : CIITA promoter activation is not affected by TNF-alpha .
10510366	0	IFN-gamma	103,112	TNF-alpha	78,87	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	production|amod|START_ENTITY enhancement|nmod|production enhancement|amod|END_ENTITY	A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells .
11130781	0	IFN-gamma	28,37	TNF-alpha	93,102	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|acl|primed primed|dobj|hepatocyte hepatocyte|appos|cells cells|nmod|manner manner|amod|END_ENTITY	LPS induces direct death of IFN-gamma primed murine embryonic hepatocyte , BNL_CL2 cells in a TNF-alpha independent manner .
11737065	0	IFN-gamma	0,9	TNF-alpha	26,35	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IFN-gamma synergizes with TNF-alpha but not with viable H. _ pylori in up-regulating CXC chemokine secretion in gastric epithelial cells .
12950679	0	IFN-gamma	61,70	TNF-alpha	50,59	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|CD40L CD40L|appos|IL-12 IL-12|appos|END_ENTITY	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
1436241	0	IFN-gamma	21,30	TNF-alpha	44,53	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	IFN-alpha|dep|START_ENTITY IFN-alpha|dep|END_ENTITY	Cytokine -LRB- IFN-alpha , IFN-gamma , IL-1-alpha , TNF-alpha -RRB- - induced modulation of HLA cell surface expression in human breast_cancer cell lines .
15699106	0	IFN-gamma	43,52	TNF-alpha	14,23	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of TNF-alpha gene expression by IFN-gamma and pamidronate in murine macrophages : regulation by STAT1-dependent pathways .
15790516	0	IFN-gamma	0,9	TNF-alpha	42,51	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	primes|amod|START_ENTITY macrophages|nsubj|primes macrophages|nmod|expression expression|amod|END_ENTITY	IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and non-stimulatory amounts of microparticulate beta-glucan .
15806975	0	IFN-gamma	68,77	TNF-alpha	109,118	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
16258194	0	IFN-gamma	27,36	TNF-alpha	16,25	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	IL-17|appos|START_ENTITY IL-17|compound|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16332515	0	IFN-gamma	14,23	TNF-alpha	38,47	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Modulation of IFN-gamma production by TNF-alpha in macrophages from the tumor environment : significance as an angiogenic switch .
16513426	0	IFN-gamma	30,39	TNF-alpha	41,50	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	IL-5|appos|START_ENTITY IL-5|appos|END_ENTITY	Evaluation of cytokines -LRB- MIG , IFN-gamma , TNF-alpha , IL-4 , IL-5 , and IL-10 -RRB- during the different evolutive phases of chagasic esophagopathy .
17101606	0	IFN-gamma	50,59	TNF-alpha	71,80	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	wounds|nmod|START_ENTITY synthesis|nmod|wounds Regulation|nmod|synthesis depends|nsubj|Regulation depends|nmod|END_ENTITY	Regulation of nitric_oxide synthesis in wounds by IFN-gamma depends on TNF-alpha .
17273910	0	IFN-gamma	40,49	TNF-alpha	16,25	IFN-gamma	TNF-alpha	403801(Tax:9615)	403922(Tax:9615)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Upregulation of TNF-alpha production by IFN-gamma and LPS in cultured canine keratinocytes : application to monosaccharides effects .
17786499	0	IFN-gamma	92,101	TNF-alpha	81,90	IFN-gamma	TNF-alpha	25712(Tax:10116)	24835(Tax:10116)	Gene	Gene	bFGF|appos|START_ENTITY bFGF|appos|END_ENTITY	Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta , TNF-alpha , IFN-gamma , TGF-beta , bFGF , and PDGF in rat 's gingiva .
17928538	0	IFN-gamma	0,9	TNF-alpha	50,59	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	mimic|nsubj|START_ENTITY mimic|dobj|effects effects|nmod|END_ENTITY	IFN-gamma does not mimic the catabolic effects of TNF-alpha .
19802480	0	IFN-gamma	53,62	TNF-alpha	42,51	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	IgG|amod|START_ENTITY IgG|amod|END_ENTITY	-LSB- Association between the plasma levels of TNF-alpha , IFN-gamma , IL-10 , nitric_oxide and specific IgG isotypes in the clinical forms of chronic Chagas_disease -RSB- .
20364089	0	IFN-gamma	63,72	TNF-alpha	73,82	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Control_of_vaccinia_virus skin_lesions by long-term-maintained IFN-gamma + TNF-alpha + effector/memory CD4 + lymphocytes in humans .
2117000	0	IFN-gamma	50,59	TNF-alpha	39,48	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	IL-1|dep|START_ENTITY IL-1|dep|END_ENTITY	Effects of associated cytokines -LRB- IL-1 , TNF-alpha , IFN-gamma and TGF-beta -RRB- on collagen and glycosaminoglycan production by cultured human synovial cells .
2118480	0	IFN-gamma	97,106	TNF-alpha	69,78	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Priming the macrophage respiratory burst with IL-4 : enhancement with TNF-alpha but inhibition by IFN-gamma .
21591983	0	IFN-gamma	53,62	TNF-alpha	17,26	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	GPIA|appos|START_ENTITY GPIA|compound|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
2475518	0	IFN-gamma	29,38	TNF-alpha	73,82	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Effects of interferon-gamma -LRB- IFN-gamma -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on the expression of LFA-1 in the moderate phenotype of leukocyte_adhesion_deficiency -LRB- LAD -RRB- .
3131759	0	IFN-gamma	117,126	TNF-alpha	84,93	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY tumor_necrosis_factor-alpha|appos|END_ENTITY	Antiproliferative effects exerted by recombinant human tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- on human pancreatic_tumor cell lines .
3141050	0	IFN-gamma	102,111	TNF-alpha	71,80	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Synergistic enhancement of the antitumor activity of recombinant human TNF-alpha by recombinant human IFN-gamma .
7544321	0	IFN-gamma	37,46	TNF-alpha	109,118	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY synergizes|nmod|IL-2 synergizes|xcomp|promote promote|dobj|synthesis synthesis|nmod|END_ENTITY	Tumor-derived factor synergizes with IFN-gamma and LPS , IL-2 or TNF-alpha to promote macrophage synthesis of TNF-alpha and TNF_receptors for autocrine induction of nitric_oxide synthase and enhanced nitric_oxide-mediated tumor_cytotoxicity .
7636207	0	IFN-gamma	34,43	TNF-alpha	74,83	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes .
7683323	1	IFN-gamma	189,198	TNF-alpha	221,230	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	MIF and IFN-gamma synergize with lipid_A to mediate migration inhibition but only IFN-gamma induces production of TNF-alpha and nitric_oxide .
8029644	0	IFN-gamma	0,9	TNF-alpha	145,154	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	internalization|amod|START_ENTITY internalization|dep|down-regulates down-regulates|acl|induced induced|dobj|release release|nmod|END_ENTITY	IFN-gamma inhibits internalization of soluble aminated beta-1 ,3 - D-glucan by macrophages and thereby down-regulates the glucan induced release of TNF-alpha and IL-1_beta .
8038591	0	IFN-gamma	106,115	TNF-alpha	76,85	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	interferon-gamma|appos|START_ENTITY factor-alpha|appos|interferon-gamma factor-alpha|appos|END_ENTITY	Isolated perfusion of the limb with high-dose tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , interferon-gamma -LRB- IFN-gamma -RRB- and melphalan for melanoma stage III .
8038594	0	IFN-gamma	161,170	TNF-alpha	117,126	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	melphalan|appos|START_ENTITY factor-alpha|appos|melphalan factor-alpha|appos|END_ENTITY	Treatment of in-transit metastases from cutaneous melanoma by isolation perfusion with tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , melphalan and interferon-gamma -LRB- IFN-gamma -RRB- .
8666424	0	IFN-gamma	27,36	TNF-alpha	38,47	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	START_ENTITY|dep|IL-4 IL-4|compound|END_ENTITY	Effect of human cytokines -LRB- IFN-gamma , TNF-alpha , IL-1_beta , IL-4 -RRB- on porcine endothelial cells : induction of MHC and adhesion molecules and functional significance of these changes .
8831687	0	IFN-gamma	46,55	TNF-alpha	0,9	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY liver|nmod|mouse expression|nmod|liver expression|amod|END_ENTITY	TNF-alpha gene expression in the liver of the IFN-gamma transgenic mouse with chronic_active_hepatitis .
8973622	0	IFN-gamma	234,243	TNF-alpha	201,210	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	Raised anti-endothelial cell autoantibodies -LRB- AECA -RRB- , but not anti-neutrophil cytoplasmic autoantibodies -LRB- ANCA -RRB- , in recurrent oral ulceration : modulation of AECA binding by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- .
9069539	0	IFN-gamma	139,148	TNF-alpha	164,173	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY infection|acl|induced clofazimine|nmod|infection activity|nmod|clofazimine Enhancement|nmod|activity mediated|nsubjpass|Enhancement mediated|nmod|END_ENTITY	Enhancement of antibacterial activity of clofazimine against Mycobacterium_avium-Mycobacterium_intracellulare complex infection induced by IFN-gamma is mediated by TNF-alpha .
9378494	0	IFN-gamma	143,152	TNF-alpha	182,191	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Generation of dendritic cells from bone marrow progenitors using GM-CSF , TNF-alpha , and additional cytokines : antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1 .
9379667	0	IFN-gamma	111,120	TNF-alpha	100,109	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	-LSB- Concentration of selected cytokines in subretinal fluid in patients with retinal_detachment -LRB- IL-8 , TNF-alpha , IFN-gamma -RRB- -RSB- .
9472684	0	IFN-gamma	119,128	TNF-alpha	83,92	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	interferon-gamma|dep|START_ENTITY Apoptosis|amod|interferon-gamma Apoptosis|nmod|and/or and/or|appos|END_ENTITY	Apoptosis of colorectal_adenocarcinoma -LRB- COLO 201 -RRB- by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and/or interferon-gamma -LRB- IFN-gamma -RRB- , resulting from down-modulation of Bcl-2 expression .
9541578	0	IFN-gamma	132,141	TNF-alpha	18,27	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	generated|nmod|START_ENTITY nitric_oxide|acl|generated production|nmod|nitric_oxide prerequisite|nmod|production prerequisite|nsubj|END_ENTITY	IFN-gamma-induced TNF-alpha is a prerequisite for in vitro production of nitric_oxide generated in murine peritoneal macrophages by IFN-gamma .
9566791	0	IFN-gamma	174,183	TNF-alpha	219,228	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Differential potentiation of anti-mycobacterial activity and reactive nitrogen intermediate-producing ability of murine peritoneal macrophages activated by interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- .
9570555	0	IFN-gamma	188,197	TNF-alpha	104,113	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY maintaining|nmod|absence plays|advcl|maintaining plays|nsubj|END_ENTITY	Factors involved in regulating primary and secondary immunity to infection with Histoplasma_capsulatum : TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma .
9631453	0	IFN-gamma	0,9	TNF-alpha	58,67	IFN-gamma	TNF-alpha	25712(Tax:10116)	24835(Tax:10116)	Gene	Gene	production|amod|START_ENTITY triggered|nsubj|production triggered|nmod|END_ENTITY	IFN-gamma production of adult rat astrocytes triggered by TNF-alpha .
9649226	0	IFN-gamma	147,156	TNF-alpha	114,123	IFN-gamma	TNF-alpha	3458	7124	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	Detection of Fcgamma receptors on human endothelial cells stimulated with cytokines tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- .
9766626	0	IFN-gamma	73,82	TNF-alpha	135,144	IFN-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	LPS|compound|START_ENTITY LPS|dep|role role|nmod|END_ENTITY	Ionizing radiation potentiates the induction of nitric_oxide_synthase by IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha .
10975834	0	IFN-gamma	43,52	Tap-1	29,34	IFN-gamma	Tap-1	3458	6890	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Synergistic induction of the Tap-1 gene by IFN-gamma and lipopolysaccharide in macrophages is regulated by STAT1 .
8609382	0	IFN-gamma	29,38	Th1	65,68	IFN-gamma	Th1	15978(Tax:10090)	57314(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Vitamin_A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway .
17115897	0	IFN-gamma	18,27	Thrombin	0,8	IFN-gamma	Thrombin	3458	2147	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Thrombin inhibits IFN-gamma production in human peripheral blood mononuclear cells by promoting a Th2 profile .
2493502	0	IFN-gamma	48,57	Tumor_necrosis_factor	0,21	IFN-gamma	Tumor necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Tumor_necrosis_factor synergistically acts with IFN-gamma to regulate Ly-6A / E expression in T lymphocytes , thymocytes and bone marrow cells .
10454343	0	IFN-gamma	43,52	Tumor_necrosis_factor-alpha	0,27	IFN-gamma	Tumor necrosis factor-alpha	3458	7124	Gene	Gene	complex|amod|START_ENTITY signals|nmod|complex signals|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha signals to the IFN-gamma receptor complex to increase Stat1alpha activation .
1387149	0	IFN-gamma	49,58	Tumor_necrosis_factor-alpha	0,27	IFN-gamma	Tumor necrosis factor-alpha	3458	7124	Gene	Gene	expression|amod|START_ENTITY up-regulate|dobj|expression up-regulate|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha and IL-6 up-regulate IFN-gamma receptor gene expression in human monocytic THP-1 cells by transcriptional and post-transcriptional mechanisms .
1918966	0	IFN-gamma	65,74	Tumor_necrosis_factor-alpha	0,27	IFN-gamma	Tumor necrosis factor-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	primed|advmod|START_ENTITY macrophages|amod|primed activity|nmod|macrophages triggers|dobj|activity triggers|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha triggers antitoxoplasmal activity of IFN-gamma primed macrophages .
9010276	0	IFN-gamma	31,40	bcl-2	92,97	IFN-gamma	bcl-2	3458	596	Gene	Gene	IL-5|appos|START_ENTITY inhibits|nsubj|IL-5 inhibits|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	IL-5 but not interferon-gamma -LRB- IFN-gamma -RRB- inhibits eosinophil apoptosis by up-regulation of bcl-2 expression .
9490649	0	IFN-gamma	83,92	bcl-2	26,31	IFN-gamma	bcl-2	3458	596	Gene	Gene	express|nmod|START_ENTITY express|dobj|proteins proteins|amod|END_ENTITY	Human eosinophils express bcl-2 family proteins : modulation of Mcl-1 expression by IFN-gamma .
9621132	0	IFN-gamma	93,102	bcl-2	33,38	IFN-gamma	bcl-2	3458	596	Gene	Gene	immunotherapy|nmod|START_ENTITY immunotherapy|amod|END_ENTITY	Alteration of cytokine genes and bcl-2 expression following immunotherapy with intralesional IFN-gamma in a patient with tumor-stage mycosis_fungoides .
2115549	0	IFN-gamma	150,159	beta_3	83,89	IFN-gamma	beta 3	15978(Tax:10090)	12297(Tax:10090)	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	Macrophage deactivating factor and transforming growth factors-beta 1 - beta_2 and - beta_3 inhibit induction of macrophage nitrogen_oxide synthesis by IFN-gamma .
15212707	0	IFN-gamma	0,9	cAMP/PKA/CREB	20,33	IFN-gamma	cAMP/PKA/CREB	15978(Tax:10090)	12796;12912	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages .
7722423	0	IFN-gamma	0,9	cathepsin_H	20,31	IFN-gamma	cathepsin H	15978(Tax:10090)	13036(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	IFN-gamma increases cathepsin_H mRNA levels in mouse macrophages .
15728492	0	IFN-gamma	99,108	cyclooxygenase-2	68,84	IFN-gamma	cyclooxygenase-2	15978(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Involvement of TNF and NF-kappa_B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages .
9725242	0	IFN-gamma	83,92	cyclooxygenase-2	20,36	IFN-gamma	cyclooxygenase-2	3458	5743	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Novel regulation of cyclooxygenase-2 expression and prostaglandin_E2 production by IFN-gamma in human macrophages .
2968406	0	IFN-gamma	6,15	envelope_protein	88,104	IFN-gamma	envelope protein	3458	64006	Gene	Gene	production|compound|START_ENTITY inhibited|nsubjpass|production inhibited|nmod|END_ENTITY	Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope_protein .
15067074	0	IFN-gamma	0,9	gp91phox	18,26	IFN-gamma	gp91phox	3458	1536	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IFN-gamma induces gp91phox expression in human monocytes via protein_kinase_C-dependent phosphorylation of PU .1 .
12646658	0	IFN-gamma	0,9	high_mobility_group_box_1	18,43	IFN-gamma	high mobility group box 1	3458	3146	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	IFN-gamma induces high_mobility_group_box_1 protein release partly through a TNF-dependent mechanism .
11171562	0	IFN-gamma	0,9	iNOS	29,33	IFN-gamma	iNOS	15978(Tax:10090)	18126(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	IFN-gamma + LPS induction of iNOS is modulated by ERK , JNK/SAPK , and p38 -LRB- mapk -RRB- in a mouse macrophage cell line .
11704648	0	IFN-gamma	170,179	iNOS	111,115	IFN-gamma	iNOS	15978(Tax:10090)	18126(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY induced|nmod|interferon-gamma expression|acl|induced inducible_nitric_oxide_synthase|dep|expression inducible_nitric_oxide_synthase|appos|END_ENTITY	N - -LSB- 3,4-dimethoxycinnamoyl -RSB- - anthranilic_acid -LRB- tranilast -RRB- suppresses microglial inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression and activity induced by interferon-gamma -LRB- IFN-gamma -RRB- .
15591835	0	IFN-gamma	29,38	iNOS	11,15	IFN-gamma	iNOS	15978(Tax:10090)	18126(Tax:10090)	Gene	Gene	production|amod|START_ENTITY Effects|nmod|production Effects|nmod|inhibitor inhibitor|amod|END_ENTITY	Effects of iNOS inhibitor on IFN-gamma production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma_gondii .
15715934	0	IFN-gamma	93,102	iNOS	32,36	IFN-gamma	iNOS	3458	4843	Gene	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated END_ENTITY|nmod|cells	Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-gamma and LPS .
9058189	0	IFN-gamma	180,189	iNOS	218,222	IFN-gamma	iNOS	15978(Tax:10090)	18126(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY presence|nmod|interferon-gamma lipopolysaccharide|nmod|presence treated|nmod|lipopolysaccharide line|acl|treated activity|nmod|line Differences|nmod|activity Differences|dep|heterogeneity heterogeneity|nmod|activity activity|amod|END_ENTITY	Differences in nitric_oxide_synthase activity in a macrophage-like cell line , RAW264 .7 cells , treated with lipopolysaccharide -LRB- LPS -RRB- in the presence or absence of interferon-gamma -LRB- IFN-gamma -RRB- : possible heterogeneity of iNOS activity .
9641464	0	IFN-gamma	22,31	iNOS	45,49	IFN-gamma	iNOS	3458	4843	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric_oxide inhibition of adenylate cyclase .
10882409	0	IFN-gamma	0,9	inducible_NO_synthase	40,61	IFN-gamma	inducible NO synthase	15978(Tax:10090)	18126(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	IFN-gamma and IL-4 differently regulate inducible_NO_synthase gene expression through IRF-1 modulation .
11309299	0	IFN-gamma	28,37	interferon-gamma	10,26	IFN-gamma	interferon-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role of interferon-gamma -LRB- IFN-gamma -RRB- in tumor immunity : T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice .
12909406	0	IFN-gamma	49,58	interferon-gamma	31,47	IFN-gamma	interferon-gamma	281237(Tax:9913)	281237(Tax:9913)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Analysis of repeated tests for interferon-gamma -LRB- IFN-gamma -RRB- response and faecal_excretion for diagnosis of subclinical paratuberculosis in Danish cattle .
1318071	0	IFN-gamma	92,101	interferon-gamma	74,90	IFN-gamma	interferon-gamma	3458	3458	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interferon-alpha -LRB- IFN-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- receptors on human normal and scleroderma dermal fibroblasts in vitro .
15376464	0	IFN-gamma	29,38	interferon-gamma	11,27	IFN-gamma	interferon-gamma	3458	3458	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	A study on interferon-gamma -LRB- IFN-gamma -RRB- response by T cells stimulated by hepatitis_B virus core antigen .
8287610	0	IFN-gamma	46,55	interferon-gamma	28,44	IFN-gamma	interferon-gamma	3458	3458	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and secretion of interferon-gamma -LRB- IFN-gamma -RRB- in children with atopic_dermatitis .
8608632	0	IFN-gamma	32,41	interferon-gamma	14,30	IFN-gamma	interferon-gamma	3458	3458	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-10 , IL-12 and transforming growth factor-beta -LRB- TGF-beta -RRB- mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid_arthritis -LRB- RA -RRB- .
9099937	0	IFN-gamma	46,55	interferon-gamma	28,44	IFN-gamma	interferon-gamma	25712(Tax:10116)	25712(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cellular mRNA expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- in rats nasally tolerized against experimental autoimmune_myasthenia_gravis -LRB- EAMG -RRB- .
9276525	0	IFN-gamma	51,60	interferon-gamma	33,49	IFN-gamma	interferon-gamma	3458	3458	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hyperinducible expression of the interferon-gamma -LRB- IFN-gamma -RRB- gene and its suppression in systemic_lupus_erythematosus -LRB- SLE -RRB- .
9528891	0	IFN-gamma	59,68	interferon-gamma	41,57	IFN-gamma	interferon-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Essential pathogenic role for endogenous interferon-gamma -LRB- IFN-gamma -RRB- during disease onset phase of murine experimental_autoimmune_orchitis .
9933441	0	IFN-gamma	29,38	interferon-gamma	11,27	IFN-gamma	interferon-gamma	3458	3458	Gene	Gene	Th1|appos|START_ENTITY Th1|dep|END_ENTITY	Th1 -LRB- IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- -RRB- and Th2 -LRB- IL-10 , IL-4 -RRB- cytokine production by peripheral blood mononuclear cells -LRB- PBMC -RRB- from patients with systemic_lupus_erythematosus -LRB- SLE -RRB- .
9218751	0	IFN-gamma	76,85	interferon-gamma_inducing_factor	23,55	IFN-gamma	interferon-gamma inducing factor	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Systemic production of interferon-gamma_inducing_factor -LRB- IGIF -RRB- versus local IFN-gamma expression involved in the development of Th1 insulitis in NOD mice .
14565859	0	IFN-gamma	81,90	interferon_regulatory_factor-1_and_interferon_regulatory_factor-2	12,77	IFN-gamma	interferon regulatory factor-1 and interferon regulatory factor-2	3458	3659;3660	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	The role of interferon_regulatory_factor-1_and_interferon_regulatory_factor-2 in IFN-gamma growth inhibition of human breast_carcinoma cell lines .
15806975	0	IFN-gamma	68,77	interleukin-2	121,134	IFN-gamma	interleukin-2	3458	3558	Gene	Gene	interferon-gamma|appos|START_ENTITY efficacy|appos|interferon-gamma END_ENTITY|nsubj|efficacy	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
12034035	0	IFN-gamma	0,9	interleukin-4	24,37	IFN-gamma	interleukin-4	3458	3565	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	IFN-gamma downregulates interleukin-4 functional activity on monocytes by multiple mechanisms .
11673527	0	IFN-gamma	77,86	matrix_metalloproteinase-9	31,57	IFN-gamma	matrix metalloproteinase-9	3458	4318	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional suppression of matrix_metalloproteinase-9 gene expression by IFN-gamma and IFN-beta : critical role of STAT-1alpha .
12804068	0	IFN-gamma	0,9	osteopontin	23,34	IFN-gamma	osteopontin	3458	6696	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	IFN-gamma induction of osteopontin expression in human monocytoid cells .
10638704	0	IFN-gamma	0,9	p21	23,26	IFN-gamma	p21	3458	1026	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	IFN-gamma induction of p21 -LRB- WAF1 -RRB- is required for cell cycle inhibition and suppression of apoptosis .
8805664	0	IFN-gamma	0,9	plasminogen_activator_inhibitor_type_1	51,89	IFN-gamma	plasminogen activator inhibitor type 1	3458	5054	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IFN-gamma inhibits thrombin - and endotoxin-induced plasminogen_activator_inhibitor_type_1 in human endothelial cells .
12579833	0	IFN-gamma	57,66	prothymosin_alpha	23,40	IFN-gamma	prothymosin alpha	15978(Tax:10090)	19231(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of recombinant prothymosin_alpha on secretion of IFN-gamma , IFN-alpha and TNF-alpha in vitro -RSB- .
1530794	0	IFN-gamma	22,31	rIFN-gamma	33,43	IFN-gamma	rIFN-gamma	3458	25712(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of recombinant IFN-gamma -LRB- rIFN-gamma -RRB- on the mechanism of human macrophage IgG FcRI-mediated cytotoxicity .
19155483	0	IFN-gamma	98,107	signaling_lymphocytic_activation_molecule-associated_protein	21,81	IFN-gamma	signaling lymphocytic activation molecule-associated protein	15978(Tax:10090)	20400(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The adaptor molecule signaling_lymphocytic_activation_molecule-associated_protein -LRB- SAP -RRB- regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression .
18209488	0	IFN-gamma	13,22	thioredoxin	42,53	IFN-gamma	thioredoxin	3458	7295	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of IFN-gamma gene expression by thioredoxin : positive feed-back regulation of Th1 response by thioredoxin and IFN-gamma .
12162878	0	IFN-gamma	0,9	transglutaminase_2	18,36	IFN-gamma	transglutaminase 2	25712(Tax:10116)	56083(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IFN-gamma induces transglutaminase_2 expression in rat small intestinal cells .
21515794	0	IFN-gamma	54,63	tristetraprolin	72,87	IFN-gamma	tristetraprolin	3458	7538	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Posttranscriptional regulation of IL-23 expression by IFN-gamma through tristetraprolin .
10933609	0	IFN-gamma	0,9	tumor_necrosis_factor-alpha	72,99	IFN-gamma	tumor necrosis factor-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effects effects|nmod|PGE2 PGE2|nmod|production production|nmod|END_ENTITY	IFN-gamma inhibits the suppressive effects of PGE2 on the production of tumor_necrosis_factor-alpha by mouse macrophages .
15806975	0	IFN-gamma	68,77	tumor_necrosis_factor-alpha	80,107	IFN-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
15812247	0	IFN-gamma	40,49	tumor_necrosis_factor-alpha	97,124	IFN-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	influences|nmod|START_ENTITY influences|nmod|activation activation|nmod|NF-kappaB NF-kappaB|nmod|END_ENTITY	Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor_necrosis_factor-alpha .
18802049	0	IFN-gamma-induced	0,17	TNF-alpha	18,27	IFN-gamma-induced	TNF-alpha	56045(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	IFN-gamma-induced TNF-alpha expression is regulated by interferon_regulatory_factors_1_and_8 in mouse macrophages .
18802049	0	IFN-gamma-induced	0,17	interferon_regulatory_factors_1_and_8	55,92	IFN-gamma-induced	interferon regulatory factors 1 and 8	56045(Tax:10090)	16362;15900	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	IFN-gamma-induced TNF-alpha expression is regulated by interferon_regulatory_factors_1_and_8 in mouse macrophages .
10903763	0	IFN-gamma-inducible_protein-10	56,86	CXCR3	0,5	IFN-gamma-inducible protein-10	CXCR3	3627	2833	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	CXCR3 expression and activation of eosinophils : role of IFN-gamma-inducible_protein-10 and monokine_induced_by_IFN-gamma .
12682235	0	IFN-gamma-inducible_protein-10	23,53	IFN-alpha	117,126	IFN-gamma-inducible protein-10	IFN-alpha	3627	3439	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	CpG-A-induced monocyte IFN-gamma-inducible_protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha .
17996064	0	IFN-gamma-inducible_protein_10	39,69	IFN-gamma	12,21	IFN-gamma-inducible protein 10	IFN-gamma	3627	3458	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression role|nmod|regulation role|nmod|END_ENTITY	The role of IFN-gamma in regulation of IFN-gamma-inducible_protein_10 -LRB- IP-10 -RRB- expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures .
17996064	0	IFN-gamma-inducible_protein_10	39,69	IP-10	71,76	IFN-gamma-inducible protein 10	IP-10	3627	3627	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The role of IFN-gamma in regulation of IFN-gamma-inducible_protein_10 -LRB- IP-10 -RRB- expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures .
9550417	0	IFN-gamma-inducing_factor	21,46	IL-18	14,19	IFN-gamma-inducing factor	IL-18	16173(Tax:10090)	16173(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of IL-18 -LRB- IFN-gamma-inducing_factor -RRB- gene expression .
12842994	0	IFN-gamma_R2	21,33	IGF-1	0,5	IFN-gamma R2	IGF-1	3460	3479	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	IGF-1 down-regulates IFN-gamma_R2 chain surface expression and desensitizes IFN-gamma/STAT -1 signaling in human T lymphocytes .
19346497	0	IFN-lambda1	0,11	GATA3	29,34	IFN-lambda1	GATA3	282618	2625	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IFN-lambda1 -LRB- IL-29 -RRB- inhibits GATA3 expression and suppresses Th2 responses in human naive and memory T cells .
20233967	0	IFN-lambda1	14,25	IL-4	0,4	IFN-lambda1	IL-4	282618	3565	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IL-4 enhances IFN-lambda1 -LRB- IL-29 -RRB- production by plasmacytoid DCs via monocyte secretion of IL-1Ra .
9605150	0	IFN-stimulated_gene_factor_3	31,59	IFN-gamma	0,9	IFN-stimulated gene factor 3	IFN-gamma	6772	3458	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	IFN-gamma priming up-regulates IFN-stimulated_gene_factor_3 -LRB- ISGF3 -RRB- components , augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs .
10090403	0	IFN-tau	58,65	interleukin-4	16,29	IFN-tau	interleukin-4	509166(Tax:9913)	280824(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Upregulation of interleukin-4 and IFN-gamma expression by IFN-tau , a member of the type I IFN family .
23180823	0	IFN-y	39,44	AMP-activated_protein_kinase	0,28	IFN-y	AMP-activated protein kinase	3458	5563	Gene	Gene	restricts|dobj|START_ENTITY restricts|nsubj|END_ENTITY	AMP-activated_protein_kinase restricts IFN-y signaling .
22182699	0	IFN-y	14,19	AP-2a	45,50	IFN-y	AP-2a	3458	7020	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression Modulation|nmod|END_ENTITY	Modulation of IFN-y receptor 1 expression by AP-2a influences IFN-y sensitivity of cancer cells .
26826241	0	IFN-y	76,81	Arginase-1	129,139	IFN-y	Arginase-1	3458	383	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Hepatitis_C_Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-y Production by Altering Cellular Metabolism via Arginase-1 .
23271704	0	IFN-y	32,37	BAFF	13,17	IFN-y	BAFF	3458	10673	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of BAFF expression by IFN-y via JAK/STAT signaling pathways in human intestinal epithelial cells .
21117871	0	IFN-y	22,27	Bcl-2	98,103	IFN-y	Bcl-2	3458	596	Gene	Gene	gene|amod|START_ENTITY effect|nmod|gene effect|nmod|END_ENTITY	Synergistic effect of IFN-y gene on LIGHT-induced apoptosis in HepG2 cells via down regulation of Bcl-2 .
21190613	0	IFN-y	61,66	C3_and_factor_B	75,90	IFN-y	C3 and factor B	3458	718	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	-LSB- Experimental study of effects of retinoic_acid on IL-1b and IFN-y induced C3_and_factor_B secretion in lung_cancer cell line -RSB- .
24523572	0	IFN-y	86,91	CCL5	24,28	IFN-y	CCL5	3458	6352	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|synthesis synthesis|compound|END_ENTITY	Regulation of chemokine CCL5 synthesis in human_peritoneal_fibroblasts : a key role of IFN-y .
20933471	0	IFN-y	50,55	CD4	20,23	IFN-y	CD4	3458	920	Gene	Gene	producing|dobj|START_ENTITY Characterization|acl|producing Characterization|nmod|cells cells|compound|END_ENTITY	Characterization of CD4 and CD8 T cells producing IFN-y in human latent and active tuberculosis .
21182084	0	IFN-y	69,74	CD4	40,43	IFN-y	CD4	3458	920	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Generation Generation|nmod|END_ENTITY	Generation of human Th1-like regulatory CD4 + T cells by an intrinsic IFN-y - and T-bet-dependent pathway .
21520494	0	IFN-y	55,60	CD4	62,65	IFN-y	CD4	3458	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Carica_papaya increases regulatory T cells and reduces IFN-y + CD4 + T cells in healthy human subjects .
21572994	0	IFN-y	20,25	CD4	53,56	IFN-y	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|amod|human human|xcomp|ve ve|dobj|T T|compound|END_ENTITY	Antigen-independent IFN-y production by human na ve CD4 T cells activated by IL-12 plus IL-18 .
22205032	0	IFN-y	117,122	CD4	81,84	IFN-y	CD4	3458	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas_ligand-enhanced IFN-y and nitric_oxide .
22461525	0	IFN-y	38,43	CD4	80,83	IFN-y	CD4	3458	920	Gene	Gene	IL-2|compound|START_ENTITY induces|dobj|IL-2 induces|nmod|cells cells|amod|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
22550536	0	IFN-y	54,59	CD4	5,8	IFN-y	CD4	3458	920	Gene	Gene	response|amod|START_ENTITY participate|nmod|response participate|nsubj|lymphocytes lymphocytes|compound|END_ENTITY	Both CD4 and CD8 lymphocytes participate in the IFN-y response to filamentous hemagglutinin from Bordetella_pertussis in infants , children , and adults .
22870329	0	IFN-y	126,131	CD4	60,63	IFN-y	CD4	3458	920	Gene	Gene	cells|nmod|START_ENTITY inhibits|nmod|cells inhibits|dobj|conversion conversion|nmod|cells cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
22870329	0	IFN-y	126,131	CD4	78,81	IFN-y	CD4	3458	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
23233724	0	IFN-y	0,5	CD4	11,14	IFN-y	CD4	3458	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	IFN-y from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium_tuberculosis_infection .
23255246	0	IFN-y	100,105	CD4	122,125	IFN-y	CD4	3458	920	Gene	Gene	memory|amod|START_ENTITY memory|nmod|T T|compound|END_ENTITY	Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-y memory in human CD4 -LRB- + -RRB- T lymphocytes .
23266494	0	IFN-y	58,63	CD4	78,81	IFN-y	CD4	3458	920	Gene	Gene	production|compound|START_ENTITY production|nmod|T T|compound|END_ENTITY	Depletion of IL-22 during culture enhanced antigen-driven IFN-y production by CD4 -LRB- + -RRB- T cells from patients with active TB .
23684621	0	IFN-y	76,81	CD4	97,100	IFN-y	CD4	3458	920	Gene	Gene	secretion|amod|START_ENTITY enhances|dobj|secretion enhances|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Antigen presentation by small intestinal epithelial cells uniquely enhances IFN-y secretion from CD4 + intestinal intraepithelial lymphocytes .
23772025	0	IFN-y	68,73	CD4	90,93	IFN-y	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY inhibition|nmod|production colitis|nmod|inhibition suppresses|dobj|colitis suppresses|nmod|cells cells|compound|END_ENTITY	Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-y production from CD4 T cells .
24704866	0	IFN-y	69,74	CD4	103,106	IFN-y	CD4	3458	920	Gene	Gene	START_ENTITY|acl|secreted secreted|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Downregulation of microRNA-24 and -181 parallels the upregulation of IFN-y secreted by activated human CD4 lymphocytes .
24710491	0	IFN-y	57,62	CD4	22,25	IFN-y	CD4	3458	920	Gene	Gene	Interferon-y|appos|START_ENTITY Cells|dobj|Interferon-y Cells|nsubj|END_ENTITY	Neuroantigen-Specific CD4 Cells Expressing Interferon-y -LRB- IFN-y -RRB- , Interleukin _ -LRB- IL -RRB- -2 and IL-3 in a Mutually Exclusive Manner Prevail in Experimental_Allergic_Encephalomyelitis -LRB- EAE -RRB- .
24817699	0	IFN-y	36,41	CD4	16,19	IFN-y	CD4	3458	920	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	CD70-expressing CD4 T cells produce IFN-y and IL-17 in rheumatoid_arthritis .
25196330	0	IFN-y	80,85	CD4	100,103	IFN-y	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nmod|T T|compound|END_ENTITY	Wnt5a signaling increases IL-12 secretion by human dendritic cells and enhances IFN-y production by CD4 -LRB- + -RRB- T cells .
25209422	10	IFN-y	1639,1644	CD4	1647,1650	IFN-y	CD8	3458	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The median frequency of antigen specific IFN-y + CD4 T cells increased at week two ; however , only the increase in the ESAT-6 / CFP-10-specific response was significant -LRB- P = 0 .
26347149	0	IFN-y	52,57	CD4	29,32	IFN-y	CD4	3458	920	Gene	Gene	Tregs|nmod|START_ENTITY Tregs|nsubj|Feasibility Feasibility|nmod|CD25 CD25|compound|END_ENTITY	Feasibility of up-regulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Tregs by IFN-y in myasthenia_gravis patients .
26347149	0	IFN-y	52,57	CD4	29,32	IFN-y	CD4	3458	920	Gene	Gene	Tregs|nmod|START_ENTITY Tregs|nsubj|Feasibility Feasibility|nmod|CD25 CD25|compound|END_ENTITY	Feasibility of up-regulating CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Tregs by IFN-y in myasthenia_gravis patients .
26989699	0	IFN-y	39,44	CD4	57,60	IFN-y	CD4	3458	920	Gene	Gene	Response|compound|START_ENTITY Induces|dobj|Response Induces|nmod|END_ENTITY	Group_B_Streptococcus Induces a Robust IFN-y Response by CD4 -LRB- + -RRB- T Cells in an In Vitro and In Vivo Model .
20967288	0	IFN-y	28,33	CD8	0,3	IFN-y	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY source|nmod|production +|nmod|source +|nsubj|END_ENTITY	CD8 + T cells as a source of IFN-y production in human cutaneous_leishmaniasis .
22235780	0	IFN-y	21,26	CD8	9,12	IFN-y	CD8	3458	925	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Effector CD8 + T cell IFN-y production and cytotoxicity are enhanced by mild hyperthermia .
22297636	0	IFN-y	73,78	CD8	96,99	IFN-y	CD8	3458	925	Gene	Gene	START_ENTITY|nmod|accumulation accumulation|compound|END_ENTITY	A mouse model of vitiligo with focused epidermal_depigmentation requires IFN-y for autoreactive CD8 T-cell accumulation in the skin .
23223131	0	IFN-y	107,112	CD8	0,3	IFN-y	CD8	3458	925	Gene	Gene	source|nmod|START_ENTITY T|ccomp|source T|nsubj|END_ENTITY	CD8 -LRB- + -RRB- T cells in the lesional skin of atopic_dermatitis and psoriasis patients are an important source of IFN-y , IL-13 , IL-17 , and IL-22 .
23251217	0	IFN-y	12,17	CD8	49,52	IFN-y	CD8	3458	925	Gene	Gene	capacity|compound|START_ENTITY capacity|nmod|END_ENTITY	The average IFN-y secreting capacity of specific CD8 -LRB- + -RRB- T cells is compromised while increasing copies of a single T cell epitope encoded by DNA vaccine .
23280240	0	IFN-y	83,88	CD8	28,31	IFN-y	CD8	3458	925	Gene	Gene	levels|amod|START_ENTITY T|nmod|levels T|nsubj|Maintenance Maintenance|nmod|+ +|compound|END_ENTITY	Maintenance of CMV-specific CD8 + T cell responses and the relationship of IL-27 to IFN-y levels with aging .
23684306	0	IFN-y	36,41	CD8	7,10	IFN-y	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY outsource|dobj|production outsource|nsubj|cells cells|compound|END_ENTITY	Memory CD8 T cells can outsource IFN-y production but not cytolytic killing for antiviral protection .
25015828	0	IFN-y	62,67	CD8	23,26	IFN-y	CD8	3458	925	Gene	Gene	pulse|nmod|START_ENTITY produce|dobj|pulse produce|nsubj|cells cells|compound|END_ENTITY	Antigen-specific naive CD8 + T cells produce a single pulse of IFN-y in vivo within hours of infection , but without antiviral effect .
25275588	0	IFN-y	128,133	CD8	89,92	IFN-y	CD8	3458	925	Gene	Gene	upregulating|dobj|START_ENTITY induces|advcl|upregulating induces|dobj|cells cells|amod|atrophy atrophy|advcl|activating activating|dobj|CD44 CD44|compound|END_ENTITY	Severe influenza_A -LRB- H1N1 -RRB- pdm09_infection induces thymic atrophy through activating innate CD8 -LRB- + -RRB- CD44 -LRB- hi -RRB- T cells by upregulating IFN-y .
25476730	0	IFN-y	62,67	CD8	85,88	IFN-y	CD8	3458	925	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	mTOR signaling promotes a robust and continuous production of IFN-y by human memory CD8 -LRB- + -RRB- T cells and their proliferation .
25480562	0	IFN-y	0,5	CD8	16,19	IFN-y	CD8	3458	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	IFN-y Regulates CD8 + Memory T Cell Differentiation and Survival in Response to Weak , but Not Strong , TCR Signals .
26309093	0	IFN-y	20,25	CD8	90,93	IFN-y	CD8	3458	925	Gene	Gene	Potentiation|nmod|START_ENTITY Potentiation|nmod|IL-10 IL-10|nmod|Cells Cells|compound|END_ENTITY	The Potentiation of IFN-y and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells .
25375377	0	IFN-y	0,5	CX3CL1	71,77	IFN-y	CX3CL1	3458	20312(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	IFN-y induces aberrant CD49b NK cell recruitment through regulating CX3CL1 : a novel mechanism by which IFN-y provokes pregnancy failure .
22870329	0	IFN-y	126,131	FoxP3	83,88	IFN-y	FoxP3	3458	50943	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	SA-4-1BBL costimulation inhibits conversion of conventional CD4 + T cells into CD4 + FoxP3 + T regulatory cells by production of IFN-y .
23028594	0	IFN-y	111,116	Foxp3	0,5	IFN-y	Foxp3	3458	50943	Gene	Gene	impact|nmod|START_ENTITY cells|dep|impact cells|amod|END_ENTITY	Foxp3 + regulatory T cells among tuberculosis patients : impact on prognosis and restoration of antigen specific IFN-y producing T cells .
24799116	0	IFN-y	88,93	Foxp3	48,53	IFN-y	Foxp3	3458	50943	Gene	Gene	cells|nmod|START_ENTITY development|dep|cells development|nmod|+ +|amod|END_ENTITY	y T cells restrain extrathymic development of Foxp3 + - inducible regulatory T cells via IFN-y .
20949125	0	IFN-y	57,62	IFN-a	76,81	IFN-y	IFN-a	3458	3438	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|cells cells|compound|END_ENTITY	SH2 modified STAT1 induces HLA-I expression and improves IFN-y signaling in IFN-a resistant HCV replicon cells .
25022962	0	IFN-y	39,44	IL-10	25,30	IFN-y	IL-10	3458	3586	Gene	Gene	IL-12|dep|START_ENTITY IL-12|dep|END_ENTITY	In situ cytokines -LRB- IL-4 , IL-10 , IL-12 , IFN-y -RRB- _ and_chemokines -LRB- MCP-1 , MIP-1a -RRB- gene expression in human Leishmania _ -LRB- Leishmania -RRB- _ Mexicana_infection .
26697005	0	IFN-y	10,15	IL-10	212,217	IFN-y	IL-10	3458	3586	Gene	Gene	START_ENTITY|dep|Regulation Regulation|nmod|END_ENTITY	Augmented IFN-y and TNF-a Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release ; Regulation by IL-10 .
22461525	0	IFN-y	38,43	IL-17	55,60	IFN-y	IL-17	3458	3605	Gene	Gene	IL-2|compound|START_ENTITY induces|dobj|IL-2 induces|nmod|cells cells|amod|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
24756108	0	IFN-y	44,49	IL-18	0,5	IFN-y	IL-18	3458	3606	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-18 , but not IL-12 , induces production of IFN-y in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin .
22707092	0	IFN-y	26,31	IL-1b	0,5	IFN-y	IL-1b	3458	3553	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|compound|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
23266494	0	IFN-y	58,63	IL-22	13,18	IFN-y	IL-22	3458	50616	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Depletion of IL-22 during culture enhanced antigen-driven IFN-y production by CD4 -LRB- + -RRB- T cells from patients with active TB .
23125412	0	IFN-y	0,5	IL-27	87,92	IFN-y	IL-27	3458	246778	Gene	Gene	limits|nsubj|START_ENTITY limits|nmod|modulation modulation|nmod|END_ENTITY	IFN-y limits Th9-mediated autoimmune_inflammation through dendritic cell modulation of IL-27 .
24741633	0	IFN-y	76,81	IL-27	0,5	IFN-y	IL-27	3458	246778	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|upregulation upregulation|amod|driven driven|amod|END_ENTITY	IL-27 driven upregulation of surface HLA-E expression on monocytes inhibits IFN-y release by autologous NK cells .
25194337	0	IFN-y	15,20	IL-27	0,5	IFN-y	IL-27	3458	246778	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IL-27 inhibits IFN-y induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium_tuberculosis_H37Rv infected macrophages .
22673732	0	IFN-y	34,39	IL-33	14,19	IFN-y	IL-33	3458	90865	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-33 expression by IFN-y and tumor_necrosis_factor-a in normal human epidermal keratinocytes .
24619410	0	IFN-y	0,5	IL-33	24,29	IFN-y	IL-33	3458	90865	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|level level|compound|END_ENTITY	IFN-y directly controls IL-33 protein level through a STAT1 - and LMP2-dependent mechanism .
26249267	0	IFN-y	22,27	IL-33	0,5	IFN-y	IL-33	3458	90865	Gene	Gene	production|amod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	IL-33 promotes innate IFN-y production and modulates dendritic cell response in LCMV-induced hepatitis in mice .
26249267	0	IFN-y	22,27	IL-33	0,5	IFN-y	IL-33	3458	90865	Gene	Gene	production|amod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	IL-33 promotes innate IFN-y production and modulates dendritic cell response in LCMV-induced hepatitis in mice .
21161049	0	IFN-y	62,67	IL-4	56,60	IFN-y	IL-4	3458	3565	Gene	Gene	START_ENTITY|nsubj|Effect Effect|appos|END_ENTITY	Effect of dynorphin_A -LRB- 1-17 -RRB- on proliferation and IL-2 , IL-4 , IFN-y production by peripheral blood mononuclears .
21968955	0	IFN-y	23,28	IL-4	30,34	IFN-y	IL-4	3458	3565	Gene	Gene	START_ENTITY|appos|alterations alterations|compound|IL-13 IL-13|compound|END_ENTITY	Inflammatory cytokines IFN-y , IL-4 , IL-13 and TNF-a alterations in schistosomiasis : a meta-analysis .
23980846	0	IFN-y	59,64	IL-4	80,84	IFN-y	IL-4	3458	3565	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Black currant seed oil supplementation of mothers enhances IFN-y and suppresses IL-4 production in breast milk .
25022962	0	IFN-y	39,44	IL-4	19,23	IFN-y	IL-4	3458	3565	Gene	Gene	IL-12|dep|START_ENTITY IL-12|compound|END_ENTITY	In situ cytokines -LRB- IL-4 , IL-10 , IL-12 , IFN-y -RRB- _ and_chemokines -LRB- MCP-1 , MIP-1a -RRB- gene expression in human Leishmania _ -LRB- Leishmania -RRB- _ Mexicana_infection .
25585347	0	IFN-y	30,35	IL-4	78,82	IFN-y	IL-4	3458	3565	Gene	Gene	combination|nmod|START_ENTITY Iopromide|nmod|combination induces|nsubj|Iopromide induces|dobj|activation activation|nmod|cells cells|nmod|expression expression|compound|END_ENTITY	Iopromide in combination with IFN-y induces the activation of HMC-1 cells via IL-4 and MCP-1 expression .
21524164	0	IFN-y	113,118	IL-6	0,4	IFN-y	IL-6	3458	3569	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|factor factor|amod|END_ENTITY	IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage : regulation by IFN-y .
22426116	0	IFN-y	14,19	IL-6	0,4	IFN-y	IL-6	3458	3569	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IL-6 inhibits IFN-y induced autophagy in Mycobacterium_tuberculosis_H37Rv infected macrophages .
22707092	0	IFN-y	26,31	IL-6	7,11	IFN-y	IL-6	3458	3569	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
26066058	0	IFN-y	123,128	IL-6	25,29	IFN-y	IL-6	3458	3569	Gene	Gene	Production|compound|START_ENTITY Associated|nmod|Production Levels|nmod|Associated Levels|nmod|END_ENTITY	High Pulmonary Levels of IL-6 and IL-1b in Children with Chronic_Suppurative_Lung_Disease Are Associated with Low Systemic IFN-y Production in Response to Non-Typeable Haemophilus_influenzae .
22707092	0	IFN-y	26,31	IL-8	13,17	IFN-y	IL-8	3458	3576	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
23807161	0	IFN-y	24,29	IRF-1	0,5	IFN-y	IRF-1	3458	3659	Gene	Gene	responsiveness|nmod|START_ENTITY responsiveness|compound|END_ENTITY	IRF-1 responsiveness to IFN-y predicts different cancer immune phenotypes .
26618646	0	IFN-y	61,66	Interferon-y	47,59	IFN-y	Interferon-y	3458	3458	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Aqueous_Tear_Deficiency Increases Conjunctival Interferon-y -LRB- IFN-y -RRB- Expression and Goblet Cell Loss .
24973639	0	IFN-y	25,30	Interleukin-28A	0,15	IFN-y	Interleukin-28A	3458	282616	Gene	Gene	production|amod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	Interleukin-28A promotes IFN-y production by peripheral blood mononuclear cells from patients with Beh __ et 's _ disease .
26232426	0	IFN-y	44,49	NKp46	90,95	IFN-y	NKp46	3458	9437	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Regulatory Dendritic Cells Restrain NK Cell IFN-y Production through Mechanisms Involving NKp46 , IL-10 , and MHC Class I-Specific Inhibitory Receptors .
26232426	0	IFN-y	44,49	NKp46	90,95	IFN-y	NKp46	3458	9437	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Regulatory Dendritic Cells Restrain NK Cell IFN-y Production through Mechanisms Involving NKp46 , IL-10 , and MHC Class I-Specific Inhibitory Receptors .
26927379	0	IFN-y	1,6	PD-L1	20,25	IFN-y	PD-L1	3458	29126	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- IFN-y up-regulates PD-L1 expression in human placenta mesenchymal stem cells and enhances cell ability to induce the differentiation of IL-10 -LRB- + -RRB- T cells from cord blood - and peripheral blood-derived T cells -RSB- .
21802664	0	IFN-y	40,45	TRAIL	56,61	IFN-y	TRAIL	3458	8743	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Synergy between TLR3 and IL-18 promotes IFN-y dependent TRAIL expression in human liver NK cells .
22104728	0	IFN-y	0,5	TRAIL	84,89	IFN-y	TRAIL	3458	8743	Gene	Gene	leads|nsubj|START_ENTITY leads|nmod|apoptosis-sensitisation apoptosis-sensitisation|nmod|cells cells|compound|END_ENTITY	IFN-y combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic_carcinoma cells .
22378844	0	IFN-y	18,23	miR-155	0,7	IFN-y	miR-155	3458	406947	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	miR-155 regulates IFN-y production in natural killer cells .
22784028	0	IFN-y	0,5	osteopontin	15,26	IFN-y	osteopontin	3458	6696	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IFN-y inhibits osteopontin expression in human decidual stromal cells and can be attenuated by 1a,25-dihydroxyvitamin _ D3 .
25924431	0	IFNAR	20,25	CD25	45,49	IFNAR	CD25	3454	3669	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- Effects of altered IFNAR expression on CD4 + CD25 + treg cell dysfunction in patients with systemic_lupus_erythematosus -RSB- .
25924431	0	IFNAR	20,25	CD4	40,43	IFNAR	CD4	3454	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Effects of altered IFNAR expression on CD4 + CD25 + treg cell dysfunction in patients with systemic_lupus_erythematosus -RSB- .
18937499	0	IFNAR-1	16,23	IFN-alpha2	55,65	IFNAR-1	IFN-alpha2	3454	3440	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists .
21771110	0	IFNAR-1	26,33	OTR	57,60	IFNAR-1	OTR	443126(Tax:9940)	443138(Tax:9940)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Endometrial expression of IFNAR-1 and oxytocin_receptor -LRB- OTR -RRB- is not improved by prostaglandin analogues when compared to progestagens in ewes .
8626489	0	IFNAR-1	37,44	STAT3	22,27	IFNAR-1	STAT3	3454	6774	Gene	Gene	chain|compound|START_ENTITY association|nmod|chain association|nmod|END_ENTITY	Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor .
14980076	0	IFNAR-2	80,87	IFN-beta	19,27	IFNAR-2	IFN-beta	3455	3456	Gene	Gene	complex|nmod|START_ENTITY complex|amod|END_ENTITY	Formation of human IFN-beta complex with the soluble type I interferon receptor IFNAR-2 leads to enhanced IFN stability , pharmacokinetics , and antitumor activity in xenografted SCID mice .
16171819	0	IFNAR1	27,33	IFNalpha2	50,59	IFNAR1	IFNalpha2	3454	3440	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site .
12554654	0	IFNAR1	34,40	Tyk2	20,24	IFNAR1	Tyk2	3454	7297	Gene	Gene	expression|nummod|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression .
22874566	0	IFNG	0,4	ATF6	63,67	IFNG	ATF6	15978(Tax:10090)	226641(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	IFNG and autophagy : a critical role for the ER-stress mediator ATF6 in controlling bacterial_infections .
23255246	0	IFNG	27,31	CD4	122,125	IFNG	CD4	3458	920	Gene	Gene	promoter|compound|START_ENTITY methylation|nmod|promoter Loss|nmod|methylation associated|nsubjpass|Loss associated|nmod|development development|nmod|lymphocytes lymphocytes|amod|functional functional|dep|memory memory|nmod|T T|compound|END_ENTITY	Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-y memory in human CD4 -LRB- + -RRB- T lymphocytes .
24244422	0	IFNG	18,22	CD4	26,29	IFNG	CD4	3458	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Downregulation of IFNG in CD4 -LRB- + -RRB- T cells in lung_cancer through hypermethylation : a possible mechanism of tumor-induced immunosuppression .
10505747	0	IFNG	31,35	IFN-gamma	15,24	IFNG	IFN-gamma	3458	3458	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of an IFN-gamma gene -LRB- IFNG -RRB- polymorphism in multiple_sclerosis in Europe : effect of population structure on association with disease .
9058314	0	IFNG	38,42	interferon-gamma	15,31	IFNG	interferon-gamma	3458	3458	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of an interferon-gamma gene -LRB- IFNG -RRB- polymorphism in Danish and Finnish insulin-dependent_diabetes_mellitus -LRB- IDDM -RRB- patients and control subjects .
8206782	0	IFNG	33,37	interferon_gamma	15,31	IFNG	interferon gamma	281237(Tax:9913)	281237(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mapping of the interferon_gamma -LRB- IFNG -RRB- gene in river and swamp buffaloes by in situ hybridization .
18593809	0	IFNGR1	33,39	interferon_gamma_receptor_1	4,31	IFNGR1	interferon gamma receptor 1	3459	3459	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	The interferon_gamma_receptor_1 -LRB- IFNGR1 -RRB- -56 C/T gene polymorphism is associated with increased risk of early gastric_carcinoma .
25287681	0	IFNL3	44,49	IL28B	51,56	IFNL3	IL28B	282617	282617	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Detection of allele specific differences in IFNL3 -LRB- IL28B -RRB- mRNA expression .
19785951	0	IFN_alpha	12,21	Collagen_I_and_transforming_growth_factor_beta_1	44,92	IFN alpha	Collagen I and transforming growth factor beta 1	3439	7040	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of IFN_alpha on the expressions of Collagen_I_and_transforming_growth_factor_beta_1 in hepatic stellate cell activated by PDGF-BB -RSB- .
8907284	0	IFN_alpha	88,97	IFN_gamma	120,129	IFN alpha	IFN gamma	3439	3458	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	The comparison of 2-chlorodeoxyadenosine -LRB- 2-Cd_A -RRB- in combination with interferon alpha -LRB- IFN_alpha -RRB- or interferon_gamma -LRB- IFN_gamma -RRB- on granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- and clonogenic blasts in -LRB- CFU-L -RRB- in vitro cultures .
1931717	0	IFN_alpha	101,110	IL2	72,75	IFN alpha	IL2	3439	3558	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	Clinical experience with the combined use of recombinant interleukin-2 -LRB- IL2 -RRB- and interferon alfa-2a -LRB- IFN_alpha -RRB- in metastatic_melanoma .
1327178	0	IFN_alpha	103,112	TNF_alpha	93,102	IFN alpha	TNF alpha	3440	7124	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Relation between leukocyte counts and cortisol secretion in CML patients undergoing combined TNF_alpha / IFN_alpha therapy .
7511881	0	IFN_beta	187,195	TGF_beta_1	176,186	IFN beta	TGF beta 1	3456	7040	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interferon treatment enhances the expression of underphosphorylated -LRB- biologically-active -RRB- retinoblastoma protein in human_papilloma_virus-infected cells through the inhibitory TGF_beta_1 / IFN_beta cytokine pathway .
2329546	0	IFN_beta_2	26,36	IL-6	14,18	IFN beta 2	IL-6	3569	3569	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of IL-6 -LRB- BSF-2 / IFN_beta_2 -RRB- by mononuclear cells in premature and term infants .
3136546	0	IFN_beta_2	57,67	interleukin-6	36,49	IFN beta 2	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Cloning and expression of the human interleukin-6 -LRB- BSF-2 / IFN_beta_2 -RRB- receptor .
12794166	0	IFN_consensus_sequence-binding_protein	25,63	IFN-gamma	159,168	IFN consensus sequence-binding protein	IFN-gamma	3394	3458	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Coordinate regulation of IFN_consensus_sequence-binding_protein and caspase-1 in the sensitization of human colon_carcinoma cells to Fas-mediated apoptosis by IFN-gamma .
11498249	0	IFN_gamma	0,9	CD4	33,36	IFN gamma	CD4	281237(Tax:9913)	407098(Tax:9913)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	IFN_gamma and IL-4 production by CD4 , CD8 and WC1 gamma delta TCR -LRB- + -RRB- T cells from cattle lymph nodes and blood .
8907284	0	IFN_gamma	120,129	IFN_alpha	88,97	IFN gamma	IFN alpha	3458	3439	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	The comparison of 2-chlorodeoxyadenosine -LRB- 2-Cd_A -RRB- in combination with interferon alpha -LRB- IFN_alpha -RRB- or interferon_gamma -LRB- IFN_gamma -RRB- on granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- and clonogenic blasts in -LRB- CFU-L -RRB- in vitro cultures .
8454850	0	IFN_gamma	14,23	IFN_gamma	36,45	IFN gamma	IFN gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Mouse soluble IFN_gamma receptor as IFN_gamma inhibitor .
8454850	0	IFN_gamma	36,45	IFN_gamma	14,23	IFN gamma	IFN gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Mouse soluble IFN_gamma receptor as IFN_gamma inhibitor .
8874748	0	IFN_gamma	112,121	IL-10	105,110	IFN gamma	IL-10	3458	3586	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	Effects of Pityrosporum ovale on proliferation , immunoglobulin -LRB- IgA , G , M -RRB- synthesis and cytokine -LRB- IL-2 , IL-10 , IFN_gamma -RRB- production of peripheral blood mononuclear cells from patients with seborrhoeic_dermatitis .
11377701	0	IFN_gamma	34,43	IL-18	14,19	IFN gamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Regulation of IL-18 production by IFN_gamma and PGE2 in mouse microglial cells : involvement of NF-kB pathway in the regulatory processes .
19031096	0	IFN_gamma	106,115	IL-18	15,20	IFN gamma	IL-18	3458	3606	Gene	Gene	polymorphism|compound|START_ENTITY effect|nmod|polymorphism Association|dep|effect Association|nmod|polymorphism polymorphism|compound|END_ENTITY	Association of IL-18 gene polymorphism -LRB- -137 C -RRB- with arthritis manifestations in SLE : combined effect with IFN_gamma gene polymorphism -LRB- +874 A -RRB- .
11057100	0	IFN_gamma	51,60	IL-2	29,33	IFN gamma	IL-2	3458	3558	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	-LSB- Secretion of interleukin-2 -LRB- IL-2 -RRB- and interferon -LRB- IFN_gamma -RRB- in whole blood cell culture stimulated with mitogens in patients with lung_neoplasms -RSB- .
8103776	0	IFN_gamma	78,87	IL-2	62,66	IFN gamma	IL-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Vasoactive intestinal peptide downregulates the expression of IL-2 but not of IFN_gamma from stimulated murine T lymphocytes .
8294138	0	IFN_gamma	61,70	IL-2	56,60	IFN gamma	IL-2	3458	3558	Gene	Gene	linked|nsubjpass|START_ENTITY Activation|parataxis|linked Activation|nmod|END_ENTITY	Activation of human monocyte/macrophage cytotoxicity by IL-2 / IFN_gamma is linked to increased expression of an antitumor receptor with specificity for acetylated mannose .
8580531	0	IFN_gamma	63,72	IL-2	35,39	IFN gamma	IL-2	25712(Tax:10116)	116562(Tax:10116)	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	Opposite effects of interleukin-2 -LRB- IL-2 -RRB- and interferon_gamma -LRB- IFN_gamma -RRB- on rat atria contractility .
6175428	0	IFN_gamma	68,77	Interleukin_2	0,13	IFN gamma	Interleukin 2	3458	3558	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Interleukin_2 regulation of mitogen induction of immune_interferon -LRB- IFN_gamma -RRB- in spleen cells and thymocytes .
17579028	0	IFN_gamma	27,36	Itk	15,18	IFN gamma	Itk	15978(Tax:10090)	16428(Tax:10090)	Gene	Gene	production|compound|START_ENTITY role|nmod|production role|nmod|END_ENTITY	A key role for Itk in both IFN_gamma and IL-4 production by NKT cells .
17634555	0	IFN_gamma	63,72	STAT1	99,104	IFN gamma	STAT1	15978(Tax:10090)	20846(Tax:10090)	Gene	Gene	accumulation|nmod|START_ENTITY directs|dobj|accumulation directs|nmod|tumors tumors|acl|enhancing enhancing|dobj|effect effect|nummod|END_ENTITY	Doxorubicin directs the accumulation of interleukin-12 induced IFN_gamma into tumors for enhancing STAT1 dependent antitumor effect .
26217191	0	IFN_gamma	0,9	STAT1	66,71	IFN gamma	STAT1	25712(Tax:10116)	25124(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	IFN_gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche .
10404391	0	IFN_gamma	86,95	TNF_alpha	130,139	IFN gamma	TNF alpha	25712(Tax:10116)	24835(Tax:10116)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Induction of transcription factor interferon_regulatory_factor-1 by interferon-gamma -LRB- IFN_gamma -RRB- and tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- in FRTL-5 cells .
1898611	0	IFN_gamma	91,100	TNF_alpha	11,20	IFN gamma	TNF alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY macrophages|acl|induced molecules|nmod|macrophages expression|nmod|molecules END_ENTITY|nmod|expression	Effects of TNF_alpha on the expression of class II MHC molecules in macrophages induced by IFN_gamma : evidence for suppression at the level of transcription .
9174546	0	IFN_gamma	71,80	TNF_alpha	61,70	IFN gamma	TNF alpha	3458	7124	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Thrombocytopenia and complement activation under recombinant TNF_alpha / IFN_gamma therapy in man .
6820888	0	IFN_gamma	86,95	interferon-gamma	68,84	IFN gamma	interferon-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Antitumor effect of OK-432 -LRB- 1 -RRB- -- antitumor effect of OK-432 induced interferon-gamma -LRB- IFN_gamma -RRB- -RSB- .
1533630	0	IFN_gamma	74,83	interferon_gamma	56,72	IFN gamma	interferon gamma	3458	15978(Tax:10090)	Gene	Gene	Construction|appos|START_ENTITY Construction|nmod|END_ENTITY	Construction , purification , and characterization of new interferon_gamma -LRB- IFN_gamma -RRB- inhibitor proteins .
17985330	0	IFN_regulatory_factor-1	79,102	IL-27	114,119	IFN regulatory factor-1	IL-27	3659	246778	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	IFN-beta modulates the response to TLR stimulation in human DC : involvement of IFN_regulatory_factor-1 -LRB- IRF-1 -RRB- in IL-27 gene expression .
15778351	0	IFN_regulatory_factor-2	0,23	STAT1	40,45	IFN regulatory factor-2	STAT1	3660	6772	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	IFN_regulatory_factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity .
14581002	0	IFN_regulatory_factor_1	29,52	IFN-alpha	0,9	IFN regulatory factor 1	IFN-alpha	3659	3439	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	IFN-alpha and IL-12 activate IFN_regulatory_factor_1 -LRB- IRF-1 -RRB- , IRF-4 , and IRF-8 gene expression in human NK and T cells .
15661910	0	IFN_regulatory_factor_3	31,54	A20	0,3	IFN regulatory factor 3	A20	3661	28935	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	A20 is a negative regulator of IFN_regulatory_factor_3 signaling .
21856936	0	IFN_regulatory_factor_4	21,44	CD4	89,92	IFN regulatory factor 4	CD4	3662	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Simvastatin inhibits IFN_regulatory_factor_4 expression and Th17 cell differentiation in CD4 + T cells derived from patients with multiple_sclerosis .
20007534	0	IFN_regulatory_factor_5	0,23	FcgammaRIIB	67,78	IFN regulatory factor 5	FcgammaRIIB	27056(Tax:10090)	14130(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	IFN_regulatory_factor_5 is required for disease development in the FcgammaRIIB - / - Yaa and FcgammaRIIB - / - mouse models of systemic_lupus_erythematosus .
18268344	0	IFN_regulatory_factor_5	37,60	IRF5	62,66	IFN regulatory factor 5	IRF5	27056(Tax:10090)	27056(Tax:10090)	Gene	Gene	requirement|nmod|START_ENTITY requirement|appos|END_ENTITY	A cell-type-specific requirement for IFN_regulatory_factor_5 -LRB- IRF5 -RRB- in Fas-induced apoptosis .
25646302	0	IFN_regulatory_factor_8	0,23	GM-CSF	34,40	IFN regulatory factor 8	GM-CSF	15900(Tax:10090)	12981(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	IFN_regulatory_factor_8 represses GM-CSF expression in T cells to affect myeloid cell lineage differentiation .
19648273	0	IFN_regulatory_factor_8	0,23	MDM2	34,38	IFN regulatory factor 8	MDM2	15900(Tax:10090)	17246(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IFN_regulatory_factor_8 regulates MDM2 in germinal center B cells .
26790609	0	IFNa	0,4	IL-6	32,36	IFNa	IL-6	3438	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	IFNa enhances the production of IL-6 by human neutrophils activated via TLR8 .
19576240	0	IFNa1	44,49	IPS-1	16,21	IFNa1	IPS-1	100137019(Tax:8030)	57506	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Atlantic_salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappaB and localizes to mitochondria .
19576240	0	IFNa1	44,49	NF-kappaB	68,77	IFNa1	NF-kappaB	100137019(Tax:8030)	4790	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Atlantic_salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappaB and localizes to mitochondria .
12234375	0	IFNalpha	93,101	ERK	15,18	IFNalpha	ERK	3439	5594	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Protein kinase ERK contributes to differential responsiveness of human myeloma cell lines to IFNalpha .
12967644	0	IFNalpha	0,8	STAT1	48,53	IFNalpha	STAT1	3439	6772	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	IFNalpha regulates NK cell cytotoxicity through STAT1 pathway .
9121765	0	IFNalpha	0,8	p21	73,76	IFNalpha	p21	3439	1026	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate_cancer cells .
16171819	0	IFNalpha2	50,59	IFNAR1	27,33	IFNalpha2	IFNAR1	3440	3454	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site .
24970844	0	IFNb	31,35	IFI16	58,63	IFNb	IFI16	3456	3428	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Listeria_monocytogenes induces IFNb expression through an IFI16 - , cGAS - and STING-dependent pathway .
24147013	0	IFNb	37,41	IL7Ra	0,5	IFNb	IL7Ra	3456	3575	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	IL7Ra expression and upregulation by IFNb in dendritic cell subsets is haplotype-dependent .
21170271	0	IFNb	59,63	MPYS	41,45	IFNb	MPYS	3456	340061	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Cellular reactive oxygen species inhibit MPYS induction of IFNb .
26708990	0	IFNb	39,43	Syk	0,3	IFNb	Syk	15977(Tax:10090)	20963(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Syk negatively regulates TLR4-mediated IFNb and IL-10 production and promotes inflammatory responses in dendritic cells .
23675467	0	IFNb	28,32	TRIM11	0,6	IFNb	TRIM11	3456	81559	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	TRIM11 negatively regulates IFNb production and antiviral activity by targeting TBK1 .
11321126	0	IFNgamma	93,101	CD4	8,11	IFNgamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibiting|dobj|production suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	Soluble CD4 suppresses T-dependent IgG2a antibody response of CD4 loosing mice by inhibiting IFNgamma production .
15236752	0	IFNgamma	53,61	IA-2	31,35	IFNgamma	IA-2	3458	5798	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased in vivo frequency of IA-2 peptide-reactive IFNgamma + / IL-4 - T cells in type 1 diabetic subjects .
10908889	0	IFNgamma	24,32	IL-10	57,62	IFNgamma	IL-10	3458	3586	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS. BACKGROUND : MS is a chronic inflammatory disease of the CNS postulated to be a Th1 type cell-mediated autoimmune_disease .
16716911	0	IFNgamma	85,93	IL-10	115,120	IFNgamma	IL-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	In vitro effects of genistein and resveratrol on the production of interferon-gamma -LRB- IFNgamma -RRB- and interleukin-10 -LRB- IL-10 -RRB- by stimulated murine splenocytes .
12027422	0	IFNgamma	42,50	IL-18	130,135	IFNgamma	IL-18	3458	3606	Gene	Gene	responses|compound|START_ENTITY attenuates|dobj|responses attenuates|parataxis|evidence evidence|nmod|mechanisms mechanisms|nmod|END_ENTITY	Nitric_oxide attenuates beryllium-induced IFNgamma responses in chronic_beryllium_disease : evidence for mechanisms independent of IL-18 .
16269022	0	IFNgamma	30,38	IL-18	24,29	IFNgamma	IL-18	3458	3606	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Severely impaired IL-12 / IL-18 / IFNgamma axis in patients with hyper_IgE_syndrome .
17292338	0	IFNgamma	12,20	IL-18	43,48	IFNgamma	IL-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	expands|nsubj|START_ENTITY expands|dobj|responses responses|compound|END_ENTITY	CpG-induced IFNgamma expands TLR4-specific IL-18 responses in vivo .
19879772	0	IFNgamma	47,55	IL-18	89,94	IFNgamma	IL-18	3458	3606	Gene	Gene	production|compound|START_ENTITY influence|dobj|production influence|nmod|regulation regulation|nmod|receptor receptor|compound|END_ENTITY	TNFalpha and TGF-beta1 influence IL-18-induced IFNgamma production through regulation of IL-18 receptor and T-bet expression .
17158965	0	IFNgamma	0,8	IL-1beta	25,33	IFNgamma	IL-1beta	3458	3553	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central_nervous_system_tuberculosis .
18805021	0	IFNgamma	65,73	IL-1beta	23,31	IFNgamma	IL-1beta	3458	3553	Gene	Gene	activity|compound|START_ENTITY role|nmod|activity role|nmod|END_ENTITY	A synergistic role for IL-1beta and TNFalpha in monocyte-derived IFNgamma inducing activity .
18319062	0	IFNgamma	0,8	IL-23	18,23	IFNgamma	IL-23	3458	51561	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	IFNgamma enhances IL-23 production during Francisella infection of human monocytes .
20631892	0	IFNgamma	35,43	IL-6	114,118	IFNgamma	IL-6	3458	3569	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|Involvement Involvement|nmod|Pathway Pathway|compound|END_ENTITY	Activation of PPARalpha Attenuates IFNgamma and IL-1beta-induced Cell Proliferation in Astrocytes : Involvement of IL-6 Independent Pathway .
11278357	1	IFNgamma	126,134	NF-kappa_B	159,169	IFNgamma	NF-kappa B	3458	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IFNgamma inhibits cytoprotective NF-kappa_B through STAT1/IRF -1 pathways .
15708473	0	IFNgamma	154,162	TNF	191,194	IFNgamma	TNF	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Major histocompatibility complex -LRB- MHC2 + -RRB- perivascular macrophages in the axotomized facial motor nucleus are regulated by receptors for interferon-gamma -LRB- IFNgamma -RRB- and tumor_necrosis_factor -LRB- TNF -RRB- .
17928893	0	IFNgamma	88,96	TNF	45,48	IFNgamma	TNF	3458	7124	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production modulation|parataxis|regulates modulation|nmod|END_ENTITY	Insights into gene modulation by therapeutic TNF and IFNgamma antibodies : TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome .
17928893	0	IFNgamma	88,96	TNF	74,77	IFNgamma	TNF	3458	7124	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Insights into gene modulation by therapeutic TNF and IFNgamma antibodies : TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome .
17016440	0	IFNgamma	63,71	cyclooxygenase-2	32,48	IFNgamma	cyclooxygenase-2	3458	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma ; a common pathway of IFNgamma-mediated gene repression but not gene activation .
26639194	0	IFNy	6,10	CD4	25,28	IFNy	CD4	3458	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	IL-10 / IFNy co-expressing CD4 -LRB- + -RRB- T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses .
19409521	0	IFRD1	0,5	SMNA	30,34	IFRD1	SMNA	3475	94008	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23 .
19889948	0	IFT20	71,76	SPEF2	14,19	IFT20	SPEF2	55978(Tax:10090)	320277(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of SPEF2 during mouse spermatogenesis and identification of IFT20 as an interacting protein .
15208670	0	IG20	0,4	DR4/DR5	69,76	IG20	DR4/DR5	8567	8797;8795	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	IG20 -LRB- MADD splice variant-5 -RRB- , a proapoptotic protein , interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC .
24701482	0	IGE	43,46	Immunoglobulin_E	25,41	IGE	Immunoglobulin E	3497	3497	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Role of Gender and Serum Immunoglobulin_E -LRB- IGE -RRB- levels on Severity of Migraine .
20007461	0	IGF-1	35,40	AF4	0,3	IGF-1	AF4	3479	4299	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development .
21474915	0	IGF-1	52,57	AKT	38,41	IGF-1	AKT	3479	207	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Direct interaction of a-synuclein and AKT regulates IGF-1 signaling : implication of Parkinson_disease .
12062094	0	IGF-1	4,9	Akt	10,13	IGF-1	Akt	3479	207	Gene	Gene	START_ENTITY|parataxis|neuroprotective neuroprotective|nsubj|END_ENTITY	The IGF-1 / Akt pathway is neuroprotective in Huntington 's _ disease and involves Huntingtin phosphorylation by Akt .
12173037	0	IGF-1	90,95	Akt	96,99	IGF-1	Akt	3479	207	Gene	Gene	proteins|nmod|START_ENTITY Activation|nmod|proteins Activation|parataxis|END_ENTITY	Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1 / Akt signaling in human multiple_myeloma cells : therapeutic implications .
16792806	0	IGF-1	30,35	Akt	79,82	IGF-1	Akt	24482(Tax:10116)	24185(Tax:10116)	Gene	Gene	Insulin-like_growth_factor-1|appos|START_ENTITY induces|nsubj|Insulin-like_growth_factor-1 induces|dobj|activation/phosphorylation activation/phosphorylation|nmod|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- induces the activation/phosphorylation of Akt kinase and cAMP_response_element-binding_protein -LRB- CREB -RRB- by activating different signaling pathways in PC12 cells .
17498671	0	IGF-1	26,31	Akt	56,59	IGF-1	Akt	3479	207	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|acl|stimulating stimulating|dobj|END_ENTITY	Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt , ERK , and neuronal survival in hippocampal cultures .
22394561	0	IGF-1	97,102	Akt	0,3	IGF-1	Akt	3479	207	Gene	Gene	cells|nmod|START_ENTITY response|nmod|cells control|dobj|response control|nsubj|END_ENTITY	Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2 .
23472139	0	IGF-1	76,81	Akt	14,17	IGF-1	Akt	3479	207	Gene	Gene	receptor|compound|START_ENTITY involvement|nmod|receptor Activation|dep|involvement Activation|nmod|products products|amod|END_ENTITY	Activation of Akt by advanced glycation end products -LRB- AGEs -RRB- : involvement of IGF-1 receptor and caveolin-1 .
26280404	0	IGF-1	77,82	Akt	83,86	IGF-1	Akt	16000(Tax:10090)	11651(Tax:10090)	Gene	Gene	Reversal|nmod|START_ENTITY Reversal|dep|signal signal|compound|END_ENTITY	Reversal of muscle_atrophy by Zhimu and Huangbai herb pair via activation of IGF-1 / Akt and autophagy signal in cancer_cachexia .
22739988	0	IGF-1	27,32	BRCA1	0,5	IGF-1	BRCA1	3479	672	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site .
18246120	0	IGF-1	26,31	Bcr-Abl	0,7	IGF-1	Bcr-Abl	3479	25	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Bcr-Abl induces autocrine IGF-1 signaling .
25474202	0	IGF-1	0,5	Brn-4	15,20	IGF-1	Brn-4	3479	5456	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	IGF-1 Promotes Brn-4 Expression and Neuronal Differentiation of Neural Stem Cells via the PI3K/Akt Pathway .
16168389	0	IGF-1	0,5	CREB	79,83	IGF-1	CREB	3479	1385	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|nmod|END_ENTITY	IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB .
25062088	0	IGF-1	0,5	Cyr61	16,21	IGF-1	Cyr61	3479	3491	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IGF-1 regulates Cyr61 induced breast_cancer cell proliferation and invasion .
23675206	0	IGF-1	35,40	Dipeptidyl_Peptidase_IV	44,67	IGF-1	Dipeptidyl Peptidase IV	3479	1803	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of Signaling-active IGF-1 by Dipeptidyl_Peptidase_IV -LRB- DPP-IV -RRB- .
21822733	0	IGF-1	37,42	ERK1/2	14,20	IGF-1	ERK1/2	24482(Tax:10116)	50689;116590	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
17498671	0	IGF-1	26,31	FGF-2	15,20	IGF-1	FGF-2	3479	2247	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of FGF-2 with IGF-1 and BDNF in stimulating Akt , ERK , and neuronal survival in hippocampal cultures .
21822733	0	IGF-1	37,42	GAP-43	46,52	IGF-1	GAP-43	24482(Tax:10116)	29423(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|compound|END_ENTITY	Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 expression in DRG neurons with excitotoxicity induced by glutamate in vitro .
17689128	0	IGF-1	33,38	GH	29,31	IGF-1	GH	3479	2688	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Serum ghrelin levels but not GH , IGF-1 and IGFBP-3 levels are altered in patients with fibromyalgia_syndrome .
25028982	0	IGF-1	118,123	GH	85,87	IGF-1	GH	3479	2688	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	The effect of maximal physical exercise on relationships between the growth_hormone -LRB- GH -RRB- and insulin_growth_factor_1 -LRB- IGF-1 -RRB- and transcriptional activity of CYP1A2 in young ice hockey players .
15498440	0	IGF-1	7,12	GHBP	1,5	IGF-1	GHBP	3479	2690	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	-LSB- GHBP , IGF-1 and IGFBP-3 serum levels in familial short-statured and normal-statured children -RSB- .
17920708	0	IGF-1	0,5	GLUT3	15,20	IGF-1	GLUT3	3479	6515	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|nummod|END_ENTITY	IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1 .
22104347	0	IGF-1	0,5	GLUT3	51,56	IGF-1	GLUT3	24482(Tax:10116)	25551(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IGF-1 induces hypoxia-inducible factor 1a-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells .
25341521	0	IGF-1	28,33	Growth_Hormone	13,27	IGF-1	Growth Hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	Pathways|amod|START_ENTITY Prevention|dep|Pathways Prevention|compound|END_ENTITY	Conservative Growth_Hormone / IGF-1 and mTOR Signaling Pathways as a Target for Aging and Cancer Prevention : Do We Really Have an Antiaging Drug ?
25835289	0	IGF-1	81,86	Growth_Hormone	37,51	IGF-1	Growth Hormone	3479	2688	Gene	Gene	Test|compound|START_ENTITY Modulation|nmod|Test Modulation|nmod|Studied Studied|compound|END_ENTITY	Genetic and Epigenetic Modulation of Growth_Hormone Sensitivity Studied With the IGF-1 Generation Test .
16024298	0	IGF-1	49,54	Growth_hormone	0,14	IGF-1	Growth hormone	3479	2688	Gene	Gene	factor-1|appos|START_ENTITY growth|dep|factor-1 growth|amod|END_ENTITY	Growth_hormone and insulin-like growth factor-1 -LRB- IGF-1 -RRB- and their influence on cognitive aging .
18053120	0	IGF-1	83,88	Growth_hormone	0,14	IGF-1	Growth hormone	3479	2688	Gene	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubj|END_ENTITY	Growth_hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels .
19207031	0	IGF-1	78,83	Growth_hormone	0,14	IGF-1	Growth hormone	3479	2688	Gene	Gene	polymorphisms|compound|START_ENTITY associated|nmod|polymorphisms associated|nsubjpass|dose dose|amod|END_ENTITY	Growth_hormone dose in growth_hormone-deficient adults is not associated with IGF-1 gene polymorphisms .
19619004	0	IGF-1	119,124	Growth_hormone	0,14	IGF-1	Growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY states|nmod|insulin-like_growth_factor bone_loss|nmod|states protects|nmod|bone_loss protects|nsubj|END_ENTITY	Growth_hormone protects against ovariectomy-induced bone_loss in states of low circulating insulin-like_growth_factor -LRB- IGF-1 -RRB- .
20928887	0	IGF-1	77,82	Growth_hormone	0,14	IGF-1	Growth hormone	3479	14599(Tax:10090)	Gene	Gene	production|compound|START_ENTITY independent|nmod|production mediates|dobj|independent mediates|nsubj|END_ENTITY	Growth_hormone mediates pubertal skeletal development independent of hepatic IGF-1 production .
12842994	0	IGF-1	0,5	IFN-gamma_R2	21,33	IGF-1	IFN-gamma R2	3479	3460	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	IGF-1 down-regulates IFN-gamma_R2 chain surface expression and desensitizes IFN-gamma/STAT -1 signaling in human T lymphocytes .
12587838	0	IGF-1	15,20	IGF-1	39,44	IGF-1	IGF-1	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Measurement of IGF-1 , IGFBP-3 and free IGF-1 levels by ELISA in growth_hormone -LRB- GH -RRB- deficient children before and after GH replacement .
12587838	0	IGF-1	39,44	IGF-1	15,20	IGF-1	IGF-1	3479	3479	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Measurement of IGF-1 , IGFBP-3 and free IGF-1 levels by ELISA in growth_hormone -LRB- GH -RRB- deficient children before and after GH replacement .
10336989	0	IGF-1	202,207	IGF-1R	57,63	IGF-1	IGF-1R	3479	3480	Gene	Gene	pathway|compound|START_ENTITY intracellular|nmod|pathway transition|nmod|intracellular dolichyl_phosphate|nmod|transition role|nmod|dolichyl_phosphate evidence|nmod|role Expression|dep|evidence Expression|nmod|END_ENTITY	Expression of the insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in breast_cancer cells : evidence for a regulatory role of dolichyl_phosphate in the transition from an intracellular to an extracellular IGF-1 pathway .
10705577	0	IGF-1	127,132	IGF-1R	53,59	IGF-1	IGF-1R	3479	3480	Gene	Gene	pathway|compound|START_ENTITY role|nmod|pathway Expression|dep|role Expression|nmod|insulin-like_growth_factor-1_receptor insulin-like_growth_factor-1_receptor|appos|END_ENTITY	Expression of insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- and p27Kip1 in melanocytic_tumors : a potential regulatory role of IGF-1 pathway in distribution of p27Kip1 between different cyclins .
17134788	0	IGF-1	106,111	IGF-1R	31,37	IGF-1	IGF-1R	3479	3480	Gene	Gene	pathway|compound|START_ENTITY blocking|dobj|pathway enhances|advcl|blocking enhances|nsubj|Adenovirus Adenovirus|acl|expressing expressing|nmod|END_ENTITY	Adenovirus expressing shRNA to IGF-1R enhances the chemosensitivity_of_lung_cancer cell lines by blocking IGF-1 pathway .
18598360	0	IGF-1	8,13	IGF-1R	14,20	IGF-1	IGF-1R	3479	3480	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of IGF-1 / IGF-1R in regulation of invasion in DU145_prostate_cancer cells .
19751099	0	IGF-1	33,38	IGF-1R	39,45	IGF-1	IGF-1R	16000(Tax:10090)	16001(Tax:10090)	Gene	Gene	changes|nmod|START_ENTITY changes|parataxis|signaling signaling|nsubj|END_ENTITY	Temporal and regional changes in IGF-1 / IGF-1R signaling in the mouse brain after traumatic brain_injury .
19966862	0	IGF-1	4,9	IGF-1R	10,16	IGF-1	IGF-1R	3479	3480	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	The IGF-1 / IGF-1R signaling axis in the skin : a new role for the dermis in aging-associated skin_cancer .
20007139	0	IGF-1	10,15	IGF-1R	16,22	IGF-1	IGF-1R	3479	3480	Gene	Gene	START_ENTITY|parataxis|responsible responsible|nsubj|signaling signaling|compound|END_ENTITY	Autocrine IGF-1 / IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute_myeloid_leukemia : therapeutic value of neutralizing anti-IGF-1R antibody .
20504360	0	IGF-1	23,28	IGF-1R	117,123	IGF-1	IGF-1R	3479	3480	Gene	Gene	induced|dep|START_ENTITY induced|dobj|proliferation proliferation|nmod|suppression suppression|nmod|END_ENTITY	Resveratrol suppresses IGF-1 induced human colon_cancer cell proliferation and elevates apoptosis via suppression of IGF-1R / Wnt and activation of p53 signaling pathways .
20927124	0	IGF-1	38,43	IGF-1R	44,50	IGF-1	IGF-1R	3479	3480	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Propionibacterium_acnes activates the IGF-1 / IGF-1R system in the epidermis and induces keratinocyte proliferation .
21047277	0	IGF-1	47,52	IGF-1R	74,80	IGF-1	IGF-1R	3479	3480	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Polymorphisms of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF-1_receptor -LRB- IGF-1R -RRB- contribute to pathologic progression in childhood IgA nephropathy .
22342912	0	IGF-1	19,24	IGF-1R	25,31	IGF-1	IGF-1R	24482(Tax:10116)	25718(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|dep|END_ENTITY	Down-regulation of IGF-1 / IGF-1R in hippocampus of rats with vascular_dementia .
23526299	0	IGF-1	45,50	IGF-1R	51,57	IGF-1	IGF-1R	3479	3480	Gene	Gene	activation|nmod|START_ENTITY activation|parataxis|signaling signaling|nsubj|END_ENTITY	Ligand-independent activation of MET through IGF-1 / IGF-1R signaling .
24126783	0	IGF-1	0,5	IGF-1R	107,113	IGF-1	IGF-1R	24482(Tax:10116)	25718(Tax:10116)	Gene	Gene	gene-modified|amod|START_ENTITY cells|amod|gene-modified resistant|nsubj|cells resistant|xcomp|oxidative oxidative|dobj|stress stress|nmod|activation activation|nmod|signaling signaling|compound|END_ENTITY	IGF-1 gene-modified muscle-derived stem cells are resistant to oxidative stress via enhanced activation of IGF-1R / PI3K/AKT signaling and secretion of VEGF .
24726100	0	IGF-1	30,35	IGF-1R	148,154	IGF-1	IGF-1R	3479	3480	Gene	Gene	Insulin-like_growth_factor-1|appos|START_ENTITY enhances|nsubj|Insulin-like_growth_factor-1 enhances|dobj|competence competence|nmod|embryos embryos|acl|cultured cultured|advcl|modulating modulating|dobj|expression expression|nmod|receptor receptor|appos|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- enhances developmental competence of cat embryos cultured singly by modulating the expression of its receptor -LRB- IGF-1R -RRB- and reducing developmental block .
25640355	0	IGF-1	65,70	IGF-1R	89,95	IGF-1	IGF-1R	3479	3480	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|END_ENTITY	Metformin Down-regulates Endometrial_Carcinoma Cell Secretion of IGF-1 and Expression of IGF-1R .
26523469	0	IGF-1	42,47	IGF-1R	54,60	IGF-1	IGF-1R	3479	3480	Gene	Gene	expression|nmod|START_ENTITY expression|acl|using using|dobj|CHO_cell_lines CHO_cell_lines|compound|END_ENTITY	Improving expression of recombinant human IGF-1 using IGF-1R knockout CHO_cell_lines .
9539874	0	IGF-1	43,48	IGF-1R	49,55	IGF-1	IGF-1R	24482(Tax:10116)	25718(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|dep|END_ENTITY	Effects of norepinephrine on expression of IGF-1 / IGF-1R and SERCA2 in rat heart .
8743420	0	IGF-1	44,49	IGF-BP2	78,85	IGF-1	IGF-BP2	24482(Tax:10116)	25662(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF-binding_protein_2 -LRB- IGF-BP2 -RRB- in the hippocampus following cytotoxic lesion of the dentate gyrus .
1283982	0	IGF-1	42,47	IGFBP-1	76,83	IGF-1	IGFBP-1	3479	3484	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	The role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- in the pathogenesis of polycystic_ovary_syndrome .
24148095	0	IGF-1	9,14	IGFBP-1	15,22	IGF-1	IGFBP-1	3479	3484	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|axis axis|compound|END_ENTITY	Neonatal IGF-1 / IGFBP-1 axis and retinopathy_of_prematurity are associated with increased blood pressure in preterm children .
10235530	0	IGF-1	56,61	IGFBP-3	62,69	IGF-1	IGFBP-3	3479	3486	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Muscle protein catabolism after severe burn : effects of IGF-1 / IGFBP-3 treatment .
10932487	0	IGF-1	54,59	IGFBP-3	111,118	IGF-1	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	The usefulness of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- for evaluation of children with short_stature .
11524173	0	IGF-1	32,37	IGFBP-3	39,46	IGF-1	IGFBP-3	3479	3486	Gene	Gene	increase|nmod|START_ENTITY increase|dep|mediates mediates|compound|END_ENTITY	A local increase in the mammary IGF-1 : IGFBP-3 ratio mediates the mammogenic effects of estrogen and growth_hormone .
15775992	0	IGF-1	53,58	IGFBP-3	87,94	IGF-1	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-1|dep|START_ENTITY levels|amod|insulin-like_growth_factor-1 levels|appos|END_ENTITY	Putative role of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels in the development of prostate_cancer in Arab men .
17627262	0	IGF-1	6,11	IGFBP-3	13,20	IGF-1	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Serum IGF-1 , IGFBP-3 and growth_hormone levels in children with congenital_heart_disease : relationship with nutritional status , cyanosis and left ventricular functions .
17673197	0	IGF-1	65,70	IGFBP-3	99,106	IGF-1	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	Reference values for serum levels of insulin-like_growth_factor -LRB- IGF-1 -RRB- and IGF-binding_protein_3 -LRB- IGFBP-3 -RRB- and their ratio in Chinese adolescents .
18093232	0	IGF-1	0,5	IGFBP-3	7,14	IGF-1	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	IGF-1 , IGFBP-3 , VEGF and MMP-9 levels and their potential relationship with renal functions in patients with compensatory renal growth .
19944347	0	IGF-1	59,64	IGFBP-3	93,100	IGF-1	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor_1|dep|START_ENTITY levels|amod|insulin-like_growth_factor_1 levels|appos|END_ENTITY	Anthropometric correlates of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels by race/ethnicity and gender .
20567839	0	IGF-1	15,20	IGFBP-3	21,28	IGF-1	IGFBP-3	3479	3486	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|parataxis|signaling signaling|nsubj|END_ENTITY	Involvement of IGF-1 / IGFBP-3 signaling on the conspicuousness of facial pores .
21865482	0	IGF-1	96,101	IGFBP-3	102,109	IGF-1	IGFBP-3	3479	3486	Gene	Gene	/|amod|START_ENTITY ratio|amod|/ ratio|compound|END_ENTITY	Serum concentrations of insulin-like_growth_factor _ -LRB- IGF -RRB- -1 and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-1 / IGFBP-3 ratio , and markers of bone turnover : reference values for French children and adolescents and z-score comparability with other references .
21898383	0	IGF-1	34,39	IGFBP-3	50,57	IGF-1	IGFBP-3	3479	3486	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels Increase|acl|circulating Increase|parataxis|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	Increase in circulating levels of IGF-1 and IGF-1 / IGFBP-3 molar ratio over a decade is associated with colorectal_adenomatous_polyps .
22180012	0	IGF-1	92,97	IGFBP-3	126,133	IGF-1	IGFBP-3	101055342	448812(Tax:9823)	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Effects of copper on proliferation and autocrine secretion of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- in chondrocytes from newborn pigs in vitro .
22709450	0	IGF-1	30,35	IGFBP-3	61,68	IGF-1	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|appos|IGF-binding_protein-3 IGF-binding_protein-3|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-1 -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- and mammographic features .
22740980	0	IGF-1	49,54	IGFBP-3	6,13	IGF-1	IGFBP-3	3479	3486	Gene	Gene	predictor|nmod|START_ENTITY predictor|nsubj|END_ENTITY	Serum IGFBP-3 is a more effective predictor than IGF-1 and IGF-2 for the development of hepatocellular_carcinoma in patients with chronic HCV_infection .
23327101	0	IGF-1	67,72	IGFBP-3	101,108	IGF-1	IGFBP-3	678666(Tax:9103)	100539598	Gene	Gene	insulin-like_growth_factor_1|appos|START_ENTITY insulin-like_growth_factor_1|appos|END_ENTITY	Reference values for serum levels of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and IGF-binding_protein_3 -LRB- IGFBP-3 -RRB- in the West Black Sea region of Turkey .
24254307	0	IGF-1	61,66	IGFBP-3	117,124	IGF-1	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Clinical significance of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and insulinlike_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in patients with epithelial_ovarian_cancer .
24424057	0	IGF-1	29,34	IGFBP-3	145,152	IGF-1	IGFBP-3	16000(Tax:10090)	16009(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY Quantification|nmod|binding Quantification|dep|complexes complexes|compound|END_ENTITY	Quantification of binding of IGF-1 to BI_836845 , a candidate therapeutic antibody against IGF-1 and IGF-2 , and effects of this antibody on IGF-1 : IGFBP-3 complexes in vitro and in male C57BL/6 mice .
24633053	0	IGF-1	33,38	IGFBP-3	78,85	IGF-1	IGFBP-3	24482(Tax:10116)	24484(Tax:10116)	Gene	Gene	homeostasis|compound|START_ENTITY regulates|dobj|homeostasis regulates|advcl|altering altering|dobj|binding binding|nmod|END_ENTITY	Cyclic_glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1 .
24633053	0	IGF-1	89,94	IGFBP-3	78,85	IGF-1	IGFBP-3	24482(Tax:10116)	24484(Tax:10116)	Gene	Gene	altering|nmod|START_ENTITY altering|dobj|binding binding|nmod|END_ENTITY	Cyclic_glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1 .
24943688	0	IGF-1	61,66	IGFBP-3	118,125	IGF-1	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Clinical significance of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in patients with breast_cancer .
26388613	0	IGF-1	22,27	IGFBP-3	48,55	IGF-1	IGFBP-3	3479	3486	Gene	Gene	levels|nmod|START_ENTITY levels|dep|ratio ratio|amod|END_ENTITY	Circulating levels of IGF-1 , IGFBP-3 , and IGF-1 / IGFBP-3 molar ratio and colorectal_adenomas : A meta-analysis .
26388613	0	IGF-1	22,27	IGFBP-3	48,55	IGF-1	IGFBP-3	3479	3486	Gene	Gene	levels|nmod|START_ENTITY levels|dep|ratio ratio|amod|END_ENTITY	Circulating levels of IGF-1 , IGFBP-3 , and IGF-1 / IGFBP-3 molar ratio and colorectal_adenomas : A meta-analysis .
26402757	0	IGF-1	16,21	IGFBP-3	22,29	IGF-1	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|parataxis|Associated Associated|nsubj|Ratio Ratio|compound|END_ENTITY	Decreased Serum IGF-1 / IGFBP-3 Molar Ratio is Associated with Executive Function Behaviors in Type 2 Diabetic Patients with Mild Cognitive_Impairment .
26445161	0	IGF-1	16,21	IGFBP-3	22,29	IGF-1	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|parataxis|Associated Associated|nsubj|Ratio Ratio|compound|END_ENTITY	Decreased Serum IGF-1 / IGFBP-3 Molar Ratio is Associated with Executive Function Behaviors in Type 2 Diabetic Patients with Mild Cognitive_Impairment .
7688379	0	IGF-1	172,177	IGFBP-3	206,213	IGF-1	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Supplementary growth_hormone treatment of women with poor ovarian response to exogenous gonadotrophins : changes in serum and follicular fluid insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- .
8701035	0	IGF-1	135,140	IGFBP-3	124,131	IGF-1	IGFBP-3	3479	3486	Gene	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Developmentally regulated expression of IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- in human placental fibroblasts : effect of exogenous IGFBP-3 on IGF-1 action .
8701035	0	IGF-1	135,140	IGFBP-3	63,70	IGF-1	IGFBP-3	3479	3486	Gene	Gene	action|compound|START_ENTITY IGFBP-3|nmod|action effect|nmod|IGFBP-3 expression|dep|effect expression|nmod|IGF_binding_protein-3 IGF_binding_protein-3|appos|END_ENTITY	Developmentally regulated expression of IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- in human placental fibroblasts : effect of exogenous IGFBP-3 on IGF-1 action .
17619941	0	IGF-1	116,121	IGFBP3	147,153	IGF-1	IGFBP3	3479	3486	Gene	Gene	insulin_like_growth_factor-1|appos|START_ENTITY release|appos|insulin_like_growth_factor-1 irradiation|nmod|release Effects|nmod|irradiation Effects|appos|END_ENTITY	Effects of laser irradiation on the release of basic_fibroblast_growth_factor -LRB- bFGF -RRB- , insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- , and receptor of IGF-1 -LRB- IGFBP3 -RRB- from gingival fibroblasts .
22482470	0	IGF-1	66,71	IGFBP3	9,15	IGF-1	IGFBP3	3479	3486	Gene	Gene	regulator|nmod|START_ENTITY levels|dep|regulator levels|compound|END_ENTITY	Elevated IGFBP3 levels in diabetic tears : a negative regulator of IGF-1 signaling in the corneal epithelium .
24427493	0	IGF-1	81,86	IGFBP3	138,144	IGF-1	IGFBP3	3479	3486	Gene	Gene	_|appos|START_ENTITY _|nsubj|_ _|dobj|protein protein|acl:relcl|Prevent Prevent|nsubj|Levels Levels|appos|END_ENTITY	Early Aggressive Parenteral Nutrition Induced High_Insulin-like_growth_factor_1 _ -LRB- IGF-1 -RRB- _ and_insulin-like_growth factor binding protein 3 -LRB- IGFBP3 -RRB- Levels Can Prevent Risk of Retinopathy_of_Prematurity .
9541512	0	IGF-1	89,94	IGFBP3	143,149	IGF-1	IGFBP3	16000(Tax:10090)	16009(Tax:10090)	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	Regulation of experimental_autoimmune_encephalomyelitis with insulin-like_growth_factor -LRB- IGF-1 -RRB- and IGF-1 / IGF-binding_protein-3 complex -LRB- IGF-1 / IGFBP3 -RRB- .
22033984	0	IGF-1	30,35	IL-6	22,26	IGF-1	IL-6	3479	3569	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3 .
19773182	0	IGF-1	54,59	IL-8	22,26	IGF-1	IL-8	3479	3576	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type_1_diabetes_mellitus .
22303302	0	IGF-1	69,74	Insulin-Like_Growth_Factor_1	39,67	IGF-1	Insulin-Like Growth Factor 1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Single Nucleotide Polymorphisms in the Insulin-Like_Growth_Factor_1 -LRB- IGF-1 -RRB- Gene are Associated with Performance in Holstein-Friesian Dairy Cattle .
27038749	0	IGF-1	42,47	Insulin-Like_Growth_Factor_1	12,40	IGF-1	Insulin-Like Growth Factor 1	3479	3479	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of Insulin-Like_Growth_Factor_1 -LRB- IGF-1 -RRB- in brain development , maturation and neuroplasticity .
26553165	0	IGF-1	51,56	Insulin-like_Growth_Factor-1	21,49	IGF-1	Insulin-like Growth Factor-1	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Donepezil may reduce Insulin-like_Growth_Factor-1 -LRB- IGF-1 -RRB- levels in Alzheimer 's _ disease .
27089502	0	IGF-1	72,77	Insulin-like_Growth_Factor-1	42,70	IGF-1	Insulin-like Growth Factor-1	3479	3479	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Receptor-mediated Selective Impairment of Insulin-like_Growth_Factor-1 -LRB- IGF-1 -RRB- activity in Congenital_Disorders_of_Glycosylation Patients .
23619527	0	IGF-1	30,35	Insulin-like_growth_factor_1	0,28	IGF-1	Insulin-like growth factor 1	3479	3479	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar_disorder patients .
2557967	0	IGF-1	30,35	Insulin-like_growth_factor_1	0,28	IGF-1	Insulin-like growth factor 1	3479	3479	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- receptors in the human brain : quantitative autoradiographic localization .
10670656	0	IGF-1	133,138	Leptin	0,6	IGF-1	Leptin	101055342	396832(Tax:9823)	Gene	Gene	glucose|appos|START_ENTITY correlation|nmod|glucose endotoxemia|dep|correlation reduced|nmod|endotoxemia reduced|nsubjpass|expression expression|compound|END_ENTITY	Leptin expression is reduced with acute endotoxemia in the pig : correlation with glucose , insulin , and insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- .
26513500	0	IGF-1	0,5	MMP-2	50,55	IGF-1	MMP-2	3479	4313	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Level Level|nmod|END_ENTITY	IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes M ller Glial Cell Motility .
18793719	0	IGF-1	21,26	NBS1	0,4	IGF-1	NBS1	3479	4683	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	NBS1 is required for IGF-1 induced cellular proliferation through the Ras/Raf/MEK / ERK cascade .
18812566	0	IGF-1	43,48	Nedd4	0,5	IGF-1	Nedd4	16000(Tax:10090)	17999(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY controls|advcl|regulating controls|nsubj|END_ENTITY	Nedd4 controls animal growth by regulating IGF-1 signaling .
16046480	0	IGF-1	19,24	PI3K	0,4	IGF-1	PI3K	3479	5293	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone .
24160342	0	IGF-1	13,18	PI3K	19,23	IGF-1	PI3K	24482(Tax:10116)	298947(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|pathway pathway|nummod|END_ENTITY	-LSB- Role of the IGF-1 / PI3K pathway and the molecular mechanism of Fuzhenghuayu therapy in a spontaneous recovery rat model of liver_fibrosis -RSB- .
10510914	0	IGF-1	30,35	PSA	63,66	IGF-1	PSA	3479	354	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- , IGF-1 density , and IGF-1 / PSA ratio for prostate_cancer detection .
11787050	0	IGF-1	0,5	Pin1	14,18	IGF-1	Pin1	3479	5300	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry .
17989724	0	IGF-1	0,5	SREBP-1	14,21	IGF-1	SREBP-1	3479	6720	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway .
23504816	0	IGF-1	0,5	STAT5	59,64	IGF-1	STAT5	3479	6776	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	IGF-1 stimulated upregulation of cyclin_D1 is mediated via STAT5 signaling pathway in neuronal cells .
22573330	0	IGF-1	44,49	TGF-b1	106,112	IGF-1	TGF-b1	3479	7040	Gene	Gene	expression|appos|START_ENTITY expression|nmod|administration administration|appos|END_ENTITY	Inhibition of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- expression by prolonged transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- administration suppresses osteoblast differentiation .
22579999	0	IGF-1	14,19	TGF-b1	28,34	IGF-1	TGF-b1	3479	7040	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|amod|END_ENTITY	Regulation of IGF-1 but not TGF-b1 by NGF in the smooth muscle of the inflamed urinary bladder .
9682131	0	IGF-1	96,101	TGF-beta_1	52,62	IGF-1	TGF-beta 1	281239(Tax:9913)	282089(Tax:9913)	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- and insulin-like_growth_factor -LRB- IGF-1 -RRB- in bovine colostrum samples .
11962191	0	IGF-1	71,76	bFGF	114,118	IGF-1	bFGF	24482(Tax:10116)	54250(Tax:10116)	Gene	Gene	insulin-like_growth_factor_1|appos|START_ENTITY insulin-like_growth_factor_1|appos|END_ENTITY	-LSB- Experimental data for administration of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- for prevention of radiation_myelopathy -RSB- .
7852847	0	IGF-1	82,87	casein_kinase_II	14,30	IGF-1	casein kinase II	3479	1457	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of casein_kinase_II in ML-1 human myeloblastic_leukemia cells requires IGF-1 and transferrin .
10082812	0	IGF-1	30,35	growth_hormone	59,73	IGF-1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	Insulin-like_growth_factor-1|appos|START_ENTITY Insulin-like_growth_factor-1|dep|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- - induced inhibition of growth_hormone secretion is associated with sleep suppression .
10708900	0	IGF-1	13,18	growth_hormone	56,70	IGF-1	growth hormone	3479	2688	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|dep|effects effects|nmod|END_ENTITY	Secretion of IGF-1 by ovine granulosa cells : effects of growth_hormone and follicle stimulating hormone .
11577173	0	IGF-1	30,35	growth_hormone	40,54	IGF-1	growth hormone	3479	2688	Gene	Gene	Insulin-like_growth_factor_1|appos|START_ENTITY Insulin-like_growth_factor_1|dep|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- : a growth_hormone .
12587838	0	IGF-1	15,20	growth_hormone	64,78	IGF-1	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY Measurement|nmod|levels Measurement|nmod|ELISA ELISA|nmod|children children|amod|END_ENTITY	Measurement of IGF-1 , IGFBP-3 and free IGF-1 levels by ELISA in growth_hormone -LRB- GH -RRB- deficient children before and after GH replacement .
12587838	0	IGF-1	39,44	growth_hormone	64,78	IGF-1	growth hormone	3479	2688	Gene	Gene	levels|compound|START_ENTITY Measurement|nmod|levels Measurement|nmod|ELISA ELISA|nmod|children children|amod|END_ENTITY	Measurement of IGF-1 , IGFBP-3 and free IGF-1 levels by ELISA in growth_hormone -LRB- GH -RRB- deficient children before and after GH replacement .
14514630	0	IGF-1	41,46	growth_hormone	174,188	IGF-1	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY resistance|nmod|mouse abrogated|nsubjpass|resistance abrogated|nmod|deletion deletion|nmod|subunit subunit|dep|roles roles|nmod|END_ENTITY	Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding_protein-3 complex : relative roles of growth_hormone and IGF-1 in insulin resistance .
14535356	0	IGF-1	93,98	growth_hormone	42,56	IGF-1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY prolactin|appos|insulin-like_growth_factor-1 prolactin|appos|END_ENTITY	Daily profiles of plasma prolactin -LRB- PRL -RRB- , growth_hormone -LRB- GH -RRB- , insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- , luteinizing hormone -LRB- LH -RRB- , testosterone , and melatonin , and of pituitary PRL mRNA and GH mRNA in male Long Evans rats in acute phase of adjuvant_arthritis .
17270100	0	IGF-1	52,57	growth_hormone	7,21	IGF-1	growth hormone	3479	2688	Gene	Gene	sufficient|nsubj|START_ENTITY END_ENTITY|parataxis|sufficient	Silent growth_hormone secreting pituitary_adenomas : IGF-1 is not sufficient to exclude growth_hormone excess .
17270100	0	IGF-1	52,57	growth_hormone	87,101	IGF-1	growth hormone	3479	2688	Gene	Gene	sufficient|nsubj|START_ENTITY sufficient|xcomp|exclude exclude|dobj|excess excess|amod|END_ENTITY	Silent growth_hormone secreting pituitary_adenomas : IGF-1 is not sufficient to exclude growth_hormone excess .
17371460	0	IGF-1	64,69	growth_hormone	47,61	IGF-1	growth hormone	3479	2688	Gene	Gene	axis|compound|START_ENTITY Modulation|dep|axis Modulation|nmod|metabolism metabolism|nmod|END_ENTITY	Modulation of glucocorticoid metabolism by the growth_hormone - IGF-1 axis .
17991453	0	IGF-1	64,69	growth_hormone	24,38	IGF-1	growth hormone	3479	2688	Gene	Gene	determination|compound|START_ENTITY relevance|nmod|determination strategy|dep|relevance strategy|nmod|deficiency deficiency|amod|END_ENTITY	Diagnostic strategy for growth_hormone deficiency : relevance of IGF-1 determination as a screening test .
21081804	0	IGF-1	40,45	growth_hormone	23,37	IGF-1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|axis axis|appos|END_ENTITY	Role of hormonal axis , growth_hormone - IGF-1 , in the therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis .
21114510	0	IGF-1	6,11	growth_hormone	105,119	IGF-1	growth hormone	3479	2688	Gene	Gene	concentrations|nsubj|START_ENTITY concentrations|nmod|marker marker|nmod|response response|amod|END_ENTITY	Serum IGF-1 concentrations in a sample of patients with traumatic_brain_injury as a diagnostic marker of growth_hormone secretory response to glucagon stimulation testing .
21274301	0	IGF-1	23,28	growth_hormone	79,93	IGF-1	growth hormone	3479	2688	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Combined evaluation of IGF-1 and IGFBP-3 as an index of efficacy and safety in growth_hormone treated patients .
22565153	0	IGF-1	77,82	growth_hormone	35,49	IGF-1	growth hormone	3479	2688	Gene	Gene	levels|compound|START_ENTITY Comparison|nmod|levels Comparison|nmod|regimens regimens|nmod|END_ENTITY	Comparison of two dose regimens of growth_hormone -LRB- GH -RRB- with different target IGF-1 levels on glucose metabolism , lipid profile , cardiovascular function and anthropometric parameters in gh-deficient adults .
23179244	0	IGF-1	77,82	growth_hormone	27,41	IGF-1	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY axis|nsubj|insulin-like_growth_factor-1 prediction|parataxis|axis prediction|nmod|END_ENTITY	Preoperative prediction of growth_hormone -LRB- GH -RRB- / insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- axis modification and postoperative changes in candidates for bariatric surgery .
24955154	0	IGF-1	26,31	growth_hormone	99,113	IGF-1	growth hormone	3479	2688	Gene	Gene	Correlation|nmod|START_ENTITY lead|nsubj|Correlation lead|nmod|deficiency deficiency|amod|END_ENTITY	Correlation between serum IGF-1 and blood lead level in short_stature children and adolescent with growth_hormone deficiency .
25098324	0	IGF-1	67,72	growth_hormone	52,66	IGF-1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	deficient|nsubj|START_ENTITY cerebral_ischemia|parataxis|deficient cerebral_ischemia|nmod|END_ENTITY	Endothelin-1-induced focal cerebral_ischemia in the growth_hormone / IGF-1 deficient Lewis Dwarf rat .
25213432	0	IGF-1	26,31	growth_hormone	47,61	IGF-1	growth hormone	3479	2688	Gene	Gene	value|nmod|START_ENTITY value|nmod|deficiency deficiency|amod|END_ENTITY	Diagnostic value of serum IGF-1 and IGFBP-3 in growth_hormone deficiency : a systematic review with meta-analysis .
25466885	0	IGF-1	133,138	growth_hormone	81,95	IGF-1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY elements|nmod|gene elements|amod|END_ENTITY	Intrauterine_growth_restriction disrupts developmental epigenetics around distal growth_hormone response elements on the rat hepatic IGF-1 gene .
26487705	0	IGF-1	114,119	growth_hormone	67,81	IGF-1	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY element|nmod|gene element|amod|responsive responsive|amod|END_ENTITY	Intrauterine_growth_restriction perturbs nucleosome depletion at a growth_hormone responsive element in the mouse IGF-1 gene .
7688379	0	IGF-1	172,177	growth_hormone	14,28	IGF-1	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY changes|nmod|insulin-like_growth_factor-1 treatment|dep|changes treatment|amod|END_ENTITY	Supplementary growth_hormone treatment of women with poor ovarian response to exogenous gonadotrophins : changes in serum and follicular fluid insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- .
7830002	0	IGF-1	147,152	growth_hormone	131,145	IGF-1	growth hormone	610255(Tax:9615)	403795(Tax:9615)	Gene	Gene	insulin|dep|START_ENTITY insulin|compound|END_ENTITY	Effects of acute and repeated intravenous administration of L-692 ,585 , a novel non-peptidyl growth_hormone secretagogue , on plasma growth_hormone , IGF-1 , ACTH , cortisol , prolactin , insulin , and thyroxine levels in beagles .
8315259	0	IGF-1	80,85	growth_hormone	8,22	IGF-1	growth hormone	3479	2688	Gene	Gene	excretion|appos|START_ENTITY excretion|amod|END_ENTITY	Urinary growth_hormone -LRB- U-GH -RRB- excretion and serum insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in patients with alcoholic_cirrhosis .
8657365	0	IGF-1	0,5	growth_hormone	45,59	IGF-1	growth hormone	3479	2688	Gene	Gene	screening|compound|START_ENTITY screening|nmod|secretion secretion|amod|END_ENTITY	IGF-1 and IGFBP-3 screening for disorders of growth_hormone secretion .
8887152	0	IGF-1	22,27	growth_hormone	55,69	IGF-1	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Short stature and low IGF-1 and IGFBP-3 despite normal growth_hormone secretion in a 4 year-old girl with primary empty_sella syndrome .
8887900	0	IGF-1	60,65	growth_hormone	11,25	IGF-1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	treatments|appos|START_ENTITY treatments|amod|END_ENTITY	Effects of growth_hormone and insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- treatments on the nitrogen metabolism and hepatic IGF-1-messenger RNA expression in postoperative parenterally fed rats .
8995736	0	IGF-1	59,64	growth_hormone	44,58	IGF-1	growth hormone	3479	2688	Gene	Gene	axis|compound|START_ENTITY Effect|dep|axis Effect|nmod|END_ENTITY	Effect of chronic metabolic_acidosis on the growth_hormone / IGF-1 endocrine axis : new cause of growth_hormone insensitivity in humans .
8995736	0	IGF-1	59,64	growth_hormone	94,108	IGF-1	growth hormone	3479	2688	Gene	Gene	axis|compound|START_ENTITY axis|dep|cause cause|nmod|insensitivity insensitivity|amod|END_ENTITY	Effect of chronic metabolic_acidosis on the growth_hormone / IGF-1 endocrine axis : new cause of growth_hormone insensitivity in humans .
9667397	0	IGF-1	16,21	growth_hormone	86,100	IGF-1	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|parameters parameters|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Arm span , serum IGF-1 and IGFBP-3 levels as screening parameters for the diagnosis of growth_hormone deficiency in patients with myelomeningocele -- preliminary data .
24673524	0	IGF-1	0,5	iNOS	14,18	IGF-1	iNOS	3479	4843	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IGF-1 induces iNOS expression via the p38 MAPK signal pathway in the anti-apoptotic process in pulmonary artery smooth muscle cells during PAH .
22090255	0	IGF-1	18,23	insulin-like_growth_factor	25,51	IGF-1	insulin-like growth factor	3479	3479	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Recombinant human IGF-1 -LRB- insulin-like_growth_factor -RRB- therapy : where do we stand today ?
24636508	0	IGF-1	111,116	insulin-like_growth_factor	83,109	IGF-1	insulin-like growth factor	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Associations between depressive_symptoms and memory deficits vary as a function of insulin-like_growth_factor -LRB- IGF-1 -RRB- levels in healthy older adults .
10079033	0	IGF-1	48,53	insulin-like_growth_factor-1	18,46	IGF-1	insulin-like growth factor-1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Quantification of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- mRNA : development and validation of an internally standardised competitive reverse transcription-polymerase chain reaction .
10079034	0	IGF-1	48,53	insulin-like_growth_factor-1	18,46	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Quantification of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- mRNA : modulation of growth intensity by feeding results in inter - and intra-tissue-specific differences of IGF-1 mRNA expression in steers .
10719568	0	IGF-1	40,45	insulin-like_growth_factor-1	10,38	IGF-1	insulin-like growth factor-1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- on muscle and bone growth in experimental models .
10940491	0	IGF-1	116,121	insulin-like_growth_factor-1	86,114	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Tamoxifen-induced cell death in malignant_melanoma cells : possible involvement of the insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- pathway .
1596498	0	IGF-1	60,65	insulin-like_growth_factor-1	30,58	IGF-1	insulin-like growth factor-1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Effect of dietary proteins on insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- messenger ribonucleic_acid content in rat liver .
1651135	0	IGF-1	58,63	insulin-like_growth_factor-1	28,56	IGF-1	insulin-like growth factor-1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Growth-promoting effects of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- on hematopoietic cells : overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism .
19715680	0	IGF-1	38,43	insulin-like_growth_factor-1	8,36	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- in regulating cell cycle progression .
20044479	0	IGF-1	54,59	insulin-like_growth_factor-1	24,52	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Selective disruption of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- signaling via phosphoinositide-dependent_kinase-1 prevents the protective effect of IGF-1 on human cancer cell death .
20553722	0	IGF-1	42,47	insulin-like_growth_factor-1	12,40	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- in growth and reproduction in female brown house snakes -LRB- Lamprophis fuliginosus -RRB- .
22573330	0	IGF-1	44,49	insulin-like_growth_factor-1	14,42	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- expression by prolonged transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- administration suppresses osteoblast differentiation .
22632366	0	IGF-1	38,43	insulin-like_growth_factor-1	8,36	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- pathway in the pathogenesis of Graves ' _ orbitopathy .
24272080	0	IGF-1	73,78	insulin-like_growth_factor-1	43,71	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Clinical significance of serum circulating insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- mRNA in hepatocellular_carcinoma .
2850224	0	IGF-1	55,60	insulin-like_growth_factor-1	25,53	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Studies on the roles of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- / somatomedin_C -LRB- SMC -RRB- during pregnancy -RSB- .
7608381	0	IGF-1	45,50	insulin-like_growth_factor-1	15,43	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Elevated serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- levels in women with postadolescent acne .
8435198	0	IGF-1	37,42	insulin-like_growth_factor-1	7,35	IGF-1	insulin-like growth factor-1	3479	3479	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Plasma insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- concentrations in human breast_cancer .
10341452	0	IGF-1	57,62	insulin-like_growth_factor_1	27,55	IGF-1	insulin-like growth factor 1	3479	3479	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Stable production of human insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in the milk of hemi - and homozygous transgenic rabbits over several generations .
14534298	0	IGF-1	54,59	insulin-like_growth_factor_1	24,52	IGF-1	insulin-like growth factor 1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Beta-arrestin1 mediates insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- activation of phosphatidylinositol 3-kinase -LRB- PI3K -RRB- and anti-apoptosis .
1640193	0	IGF-1	51,56	insulin-like_growth_factor_1	21,49	IGF-1	insulin-like growth factor 1	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Low plasma levels of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in male patients with idiopathic_osteoporosis .
17354613	0	IGF-1	46,51	insulin-like_growth_factor_1	16,44	IGF-1	insulin-like growth factor 1	3479	3479	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in skeletal muscle physiology .
1851744	0	IGF-1	34,39	insulin-like_growth_factor_1	4,32	IGF-1	insulin-like growth factor 1	378699(Tax:8355)	378699(Tax:8355)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- receptor is responsible for mediating the effects of insulin , IGF-1 , and IGF-2 in Xenopus_laevis oocytes .
18761080	0	IGF-1	96,101	insulin-like_growth_factor_1	66,94	IGF-1	insulin-like growth factor 1	3479	3479	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Absence of association between SNPs in the promoter region of the insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- gene and longevity in the Han Chinese population .
22308338	0	IGF-1	86,91	insulin-like_growth_factor_1	56,84	IGF-1	insulin-like growth factor 1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Light stimuli control neuronal migration by altering of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- signaling .
3962685	0	IGF-1	129,134	insulin-like_growth_factor_1	99,127	IGF-1	insulin-like growth factor 1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The influence of maternal protein deprivation on the developmental pattern of serum immunoreactive insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- levels .
7867698	0	IGF-1	44,49	insulin-like_growth_factor_1	14,42	IGF-1	insulin-like growth factor 1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in the bovine oviduct during the oestrous cycle .
8408032	0	IGF-1	78,83	insulin-like_growth_factor_1	48,76	IGF-1	insulin-like growth factor 1	3479	3479	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Ethanol inhibits the autophosphorylation of the insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- receptor and IGF-1-mediated proliferation of 3T3 cells .
10435054	0	IGF-1	108,113	insulin_like_growth_factor-1	78,106	IGF-1	insulin like growth factor-1	3479	3479	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Peak and trough growth_hormone -LRB- GH -RRB- concentrations influence growth and serum insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- concentrations in short children .
23397157	0	IGF-1	110,115	insulin_like_growth_factor-1	80,108	IGF-1	insulin like growth factor-1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	The effects of induced type-I diabetes on developmental regulation of insulin _ insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- receptors in the cerebellum of rat neonates .
10607937	0	IGF-1	99,104	leptin	25,31	IGF-1	leptin	281239(Tax:9913)	280836(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|compound|END_ENTITY	Growth hormone regulates leptin gene expression in bovine adipose tissue : correlation with adipose IGF-1 expression .
24854528	0	IGF-1	52,57	leptin	44,50	IGF-1	leptin	3479	3952	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	The effect of adenotonsilectomy on ghrelin , leptin , IGF-1 levels and growth parameters in children with adenotonsillar_hypertrophy .
25141780	0	IGF-1	126,131	leptin	143,149	IGF-1	leptin	3479	3952	Gene	Gene	factor|appos|START_ENTITY intensity|appos|factor relationship|nmod|intensity relationship|dep|system system|appos|change change|compound|END_ENTITY	The relationship between moderate-to-vigorous intensity physical activity and insulin resistance , insulin-like growth factor -LRB- IGF-1 -RRB- - system 1 , leptin and weight change in healthy women during pregnancy and after delivery .
26463631	0	IGF-1	89,94	miR-425	0,7	IGF-1	miR-425	3479	494337	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-425 inhibits melanoma metastasis through repression of PI3K-Akt pathway by targeting IGF-1 .
20182617	0	IGF-1	22,27	p53	0,3	IGF-1	p53	3479	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	p53 regulation of the IGF-1 / AKT/mTOR pathways and the endosomal compartment .
20504360	0	IGF-1	23,28	p53	146,149	IGF-1	p53	3479	7157	Gene	Gene	induced|dep|START_ENTITY Wnt|dep|induced Wnt|nmod|END_ENTITY	Resveratrol suppresses IGF-1 induced human colon_cancer cell proliferation and elevates apoptosis via suppression of IGF-1R / Wnt and activation of p53 signaling pathways .
16166596	0	IGF-1	0,5	receptor_tyrosine_kinase	6,30	IGF-1	receptor tyrosine kinase	3479	5979	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	IGF-1 receptor_tyrosine_kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple_myeloma cells .
2523786	0	IGF-1	40,45	somatomedin_C	25,38	IGF-1	somatomedin C	3479	3479	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Insulin increases plasma somatomedin_C -LRB- IGF-1 -RRB- concentrations in adult type 1 diabetic patients .
2850224	0	IGF-1	55,60	somatomedin_C	62,75	IGF-1	somatomedin C	3479	3479	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Studies on the roles of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- / somatomedin_C -LRB- SMC -RRB- during pregnancy -RSB- .
7709860	0	IGF-1	101,106	somatomedin_c	86,99	IGF-1	somatomedin c	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Prevalence of malaria and its relationship to anemia , blood glucose levels , and serum somatomedin_c -LRB- IGF-1 -RRB- levels in the Solomon Islands .
20733350	0	IGF-1	0,5	zinc-finger_protein_143	28,51	IGF-1	zinc-finger protein 143	3479	7702	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	IGF-1 induces expression of zinc-finger_protein_143 in colon_cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species .
24841203	0	IGF-1R	166,172	EGFR	112,116	IGF-1R	EGFR	3480	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	A novel glycoengineered bispecific antibody format for targeted inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- and insulin-like_growth_factor_receptor_type_I -LRB- IGF-1R -RRB- demonstrating unique molecular properties .
22115966	0	IGF-1R	13,19	EGR-1	34,39	IGF-1R	EGR-1	3480	1958	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate_cancer cells .
15460409	0	IGF-1R	11,17	ER-alpha	1,9	IGF-1R	ER-alpha	25718(Tax:10116)	24890(Tax:10116)	Gene	Gene	expressions|compound|START_ENTITY END_ENTITY|appos|expressions	-LSB- ER-alpha , IGF-1R expressions and co-expressions in newborn rats with experimental hypoxic-ischemic_brain_damage -RSB- .
19946718	0	IGF-1R	28,34	ERK1/2	70,76	IGF-1R	ERK1/2	3480	5595;5594	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2 + - induced ERK1/2 and PKB phosphorylation .
22761875	0	IGF-1R	86,92	ERK1/2	71,77	IGF-1R	ERK1/2	16001(Tax:10090)	26417;26413	Gene	Gene	transactivation|compound|START_ENTITY activates|nmod|transactivation activates|dobj|END_ENTITY	GABAB receptor subunit GB1 at the cell surface independently activates ERK1/2 through IGF-1R transactivation .
20206441	0	IGF-1R	136,142	GIPC	0,4	IGF-1R	GIPC	3480	10755	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	GIPC mediates the generation of reactive oxygen species and the regulation of cancer cell proliferation by insulin-like_growth_factor-1 / IGF-1R signaling .
23460259	0	IGF-1R	26,32	GRK2	0,4	IGF-1R	GRK2	3480	156	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GRK2 negatively regulates IGF-1R signaling pathway and cyclins ' expression in HepG2 cells .
10336989	0	IGF-1R	57,63	IGF-1	202,207	IGF-1R	IGF-1	3480	3479	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|evidence evidence|nmod|role role|nmod|dolichyl_phosphate dolichyl_phosphate|nmod|transition transition|nmod|intracellular intracellular|nmod|pathway pathway|compound|END_ENTITY	Expression of the insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in breast_cancer cells : evidence for a regulatory role of dolichyl_phosphate in the transition from an intracellular to an extracellular IGF-1 pathway .
10705577	0	IGF-1R	53,59	IGF-1	127,132	IGF-1R	IGF-1	3480	3479	Gene	Gene	insulin-like_growth_factor-1_receptor|appos|START_ENTITY Expression|nmod|insulin-like_growth_factor-1_receptor Expression|dep|role role|nmod|pathway pathway|compound|END_ENTITY	Expression of insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- and p27Kip1 in melanocytic_tumors : a potential regulatory role of IGF-1 pathway in distribution of p27Kip1 between different cyclins .
17134788	0	IGF-1R	31,37	IGF-1	106,111	IGF-1R	IGF-1	3480	3479	Gene	Gene	expressing|nmod|START_ENTITY Adenovirus|acl|expressing enhances|nsubj|Adenovirus enhances|advcl|blocking blocking|dobj|pathway pathway|compound|END_ENTITY	Adenovirus expressing shRNA to IGF-1R enhances the chemosensitivity_of_lung_cancer cell lines by blocking IGF-1 pathway .
18598360	0	IGF-1R	14,20	IGF-1	8,13	IGF-1R	IGF-1	3480	3479	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of IGF-1 / IGF-1R in regulation of invasion in DU145_prostate_cancer cells .
19751099	0	IGF-1R	39,45	IGF-1	33,38	IGF-1R	IGF-1	16001(Tax:10090)	16000(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY changes|parataxis|signaling changes|nmod|END_ENTITY	Temporal and regional changes in IGF-1 / IGF-1R signaling in the mouse brain after traumatic brain_injury .
19966862	0	IGF-1R	10,16	IGF-1	4,9	IGF-1R	IGF-1	3480	3479	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	The IGF-1 / IGF-1R signaling axis in the skin : a new role for the dermis in aging-associated skin_cancer .
20007139	0	IGF-1R	16,22	IGF-1	10,15	IGF-1R	IGF-1	3480	3479	Gene	Gene	signaling|compound|START_ENTITY responsible|nsubj|signaling END_ENTITY|parataxis|responsible	Autocrine IGF-1 / IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute_myeloid_leukemia : therapeutic value of neutralizing anti-IGF-1R antibody .
20504360	0	IGF-1R	117,123	IGF-1	23,28	IGF-1R	IGF-1	3480	3479	Gene	Gene	suppression|nmod|START_ENTITY proliferation|nmod|suppression induced|dobj|proliferation induced|dep|END_ENTITY	Resveratrol suppresses IGF-1 induced human colon_cancer cell proliferation and elevates apoptosis via suppression of IGF-1R / Wnt and activation of p53 signaling pathways .
20927124	0	IGF-1R	44,50	IGF-1	38,43	IGF-1R	IGF-1	3480	3479	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Propionibacterium_acnes activates the IGF-1 / IGF-1R system in the epidermis and induces keratinocyte proliferation .
21047277	0	IGF-1R	74,80	IGF-1	47,52	IGF-1R	IGF-1	3480	3479	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Polymorphisms of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF-1_receptor -LRB- IGF-1R -RRB- contribute to pathologic progression in childhood IgA nephropathy .
22342912	0	IGF-1R	25,31	IGF-1	19,24	IGF-1R	IGF-1	25718(Tax:10116)	24482(Tax:10116)	Gene	Gene	Down-regulation|dep|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of IGF-1 / IGF-1R in hippocampus of rats with vascular_dementia .
23526299	0	IGF-1R	51,57	IGF-1	45,50	IGF-1R	IGF-1	3480	3479	Gene	Gene	signaling|nsubj|START_ENTITY activation|parataxis|signaling activation|nmod|END_ENTITY	Ligand-independent activation of MET through IGF-1 / IGF-1R signaling .
24126783	0	IGF-1R	107,113	IGF-1	0,5	IGF-1R	IGF-1	25718(Tax:10116)	24482(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling stress|nmod|activation oxidative|dobj|stress resistant|xcomp|oxidative resistant|nsubj|cells cells|amod|gene-modified gene-modified|amod|END_ENTITY	IGF-1 gene-modified muscle-derived stem cells are resistant to oxidative stress via enhanced activation of IGF-1R / PI3K/AKT signaling and secretion of VEGF .
24726100	0	IGF-1R	148,154	IGF-1	30,35	IGF-1R	IGF-1	3480	3479	Gene	Gene	receptor|appos|START_ENTITY expression|nmod|receptor modulating|dobj|expression cultured|advcl|modulating embryos|acl|cultured competence|nmod|embryos enhances|dobj|competence enhances|nsubj|Insulin-like_growth_factor-1 Insulin-like_growth_factor-1|appos|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- enhances developmental competence of cat embryos cultured singly by modulating the expression of its receptor -LRB- IGF-1R -RRB- and reducing developmental block .
25640355	0	IGF-1R	89,95	IGF-1	65,70	IGF-1R	IGF-1	3480	3479	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|END_ENTITY	Metformin Down-regulates Endometrial_Carcinoma Cell Secretion of IGF-1 and Expression of IGF-1R .
26523469	0	IGF-1R	54,60	IGF-1	42,47	IGF-1R	IGF-1	3480	3479	Gene	Gene	CHO_cell_lines|compound|START_ENTITY using|dobj|CHO_cell_lines expression|acl|using expression|nmod|END_ENTITY	Improving expression of recombinant human IGF-1 using IGF-1R knockout CHO_cell_lines .
9539874	0	IGF-1R	49,55	IGF-1	43,48	IGF-1R	IGF-1	25718(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of norepinephrine on expression of IGF-1 / IGF-1R and SERCA2 in rat heart .
24667580	0	IGF-1R	39,45	IGF-1R	81,87	IGF-1R	IGF-1R	3480	3480	Gene	Gene	Insulin-like_growth_factor_1_receptor|appos|START_ENTITY Insulin-like_growth_factor_1_receptor|nmod|target target|nmod|levels levels|compound|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic_cancer .
24667580	0	IGF-1R	81,87	IGF-1R	39,45	IGF-1R	IGF-1R	3480	3480	Gene	Gene	levels|compound|START_ENTITY target|nmod|levels Insulin-like_growth_factor_1_receptor|nmod|target Insulin-like_growth_factor_1_receptor|appos|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic_cancer .
21259294	0	IGF-1R	110,116	IR	134,136	IGF-1R	IR	25718(Tax:10116)	24954(Tax:10116)	Gene	Gene	dominance|nmod|START_ENTITY dominance|nmod|END_ENTITY	Unique expression pattern of the three insulin_receptor family members in the rat mammary gland : dominance of IGF-1R and IRR over the IR , and cyclical IGF-1R expression .
26131572	0	IGF-1R	39,45	Insulin-like_growth_factor-1_receptor	0,37	IGF-1R	Insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibition promotes expansion of human NK cells which maintain their potent antitumor activity against Ewing_sarcoma cells .
21936711	0	IGF-1R	39,45	Insulin-like_growth_factor_1_receptor	0,37	IGF-1R	Insulin-like growth factor 1 receptor	3480	3480	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- inhibitor : another arrow in the quiver - Will it hit the moving target ?
18196535	0	IGF-1R	78,84	MT1-MMP	88,95	IGF-1R	MT1-MMP	3480	4323	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Differential localization of MT1-MMP in human prostate_cancer tissue : role of IGF-1R in MT1-MMP expression .
24667580	0	IGF-1R	39,45	MiR-497	62,69	IGF-1R	MiR-497	3480	574456	Gene	Gene	Insulin-like_growth_factor_1_receptor|appos|START_ENTITY Insulin-like_growth_factor_1_receptor|nmod|target target|nmod|levels levels|compound|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic_cancer .
24667580	0	IGF-1R	81,87	MiR-497	62,69	IGF-1R	MiR-497	3480	574456	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic_cancer .
26440329	0	IGF-1R	254,260	erbB2	204,209	IGF-1R	erbB2	281848(Tax:9913)	505709(Tax:9913)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
17649826	0	IGF-1R	53,59	insulin-like_growth-factor-1_receptor	14,51	IGF-1R	insulin-like growth-factor-1 receptor	3480	3480	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth-factor-1_receptor -LRB- IGF-1R -RRB- in peripheral nerve_sheath_tumors in neurofibromatosis_type_1 .
19394223	0	IGF-1R	125,131	insulin-like_growth_factor-1_receptor	86,123	IGF-1R	insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Discovery of 3,5-disubstituted-1H-pyrrolo -LSB- 2,3-b -RSB- pyridines as potent inhibitors of the insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- tyrosine kinase .
20178321	0	IGF-1R	96,102	insulin-like_growth_factor-1_receptor	57,94	IGF-1R	insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery and SAR of thiazolidine-2 ,4 - dione analogues as insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitors via hierarchical virtual screening .
21414779	0	IGF-1R	89,95	insulin-like_growth_factor-1_receptor	50,87	IGF-1R	insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of 2,4-bis-arylamino-1 ,3 - pyrimidines as insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitors .
21640718	0	IGF-1R	84,90	insulin-like_growth_factor-1_receptor	45,82	IGF-1R	insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Dual epidermal_growth_factor_receptor -LRB- EGFR -RRB- / insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitor : a novel approach for overcoming resistance in anticancer treatment .
23373648	0	IGF-1R	91,97	insulin-like_growth_factor-1_receptor	52,89	IGF-1R	insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	tyrosine|appos|START_ENTITY tyrosine|amod|END_ENTITY	Recent advancements in small molecule inhibitors of insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- tyrosine kinase as anticancer agents .
9607000	0	IGF-1R	57,63	insulin-like_growth_factor-1_receptor	18,55	IGF-1R	insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Downregulation of insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- expression in human T lymphocyte activation .
19778024	0	IGF-1R	126,132	insulin-like_growth_factor_receptor	89,124	IGF-1R	insulin-like growth factor receptor	3480	3480	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Discovery of a 2,4-disubstituted _ pyrrolo -LSB- 1,2-f -RSB- -LSB- 1,2,4 -RSB- triazine inhibitor -LRB- BMS-754807 -RRB- of insulin-like_growth_factor_receptor -LRB- IGF-1R -RRB- kinase in clinical development .
23935097	0	IGF-1R	85,91	insulin_receptor	24,40	IGF-1R	insulin receptor	3480	3643	Gene	Gene	receptor|appos|START_ENTITY /|dobj|receptor /|nsubj|END_ENTITY	A highly selective dual insulin_receptor -LRB- IR -RRB- / insulin-like growth factor 1 receptor -LRB- IGF-1R -RRB- inhibitor derived from an extracellular_signal-regulated_kinase -LRB- ERK -RRB- inhibitor .
24810113	0	IGF-1R	0,6	let-7b	20,26	IGF-1R	let-7b	3480	406884	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	IGF-1R , a target of let-7b , mediates crosstalk between IRS-2 / Akt and MAPK pathways to promote proliferation of oral_squamous_cell_carcinoma .
26297545	0	IGF-1R	19,25	miR-99b	0,7	IGF-1R	miR-99b	3480	407056	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	miR-99b suppresses IGF-1R expression and contributes to inhibition of cell proliferation in human epidermal keratinocytes .
26868851	0	IGF-1_R	84,91	miR-139	0,7	IGF-1 R	miR-139	16001(Tax:10090)	387157(Tax:10090)	Gene	Gene	Functions|nmod|START_ENTITY Functions|amod|END_ENTITY	miR-139 Functions as An Antioncomir to Repress Glioma_Progression Through Targeting IGF-1_R , AMY-1 , and PGC-1b .
10749889	0	IGF-1_receptor	46,60	Estrogen_receptor_alpha	0,23	IGF-1 receptor	Estrogen receptor alpha	3480	2099	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Estrogen_receptor_alpha rapidly activates the IGF-1_receptor pathway .
20555424	0	IGF-1_receptor	33,47	IRS-2	14,19	IGF-1 receptor	IRS-2	25718(Tax:10116)	29376(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of IRS-2 signaling by IGF-1_receptor in the diabetic rat heart .
20438504	0	IGF-2	29,34	Myostatin	0,9	IGF-2	Myostatin	281240(Tax:9913)	281187(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle .
15380337	0	IGF-2	53,58	insulin-like_growth_factor-2	23,51	IGF-2	insulin-like growth factor-2	3481	3481	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Aberrant expression of insulin-like_growth_factor-2 -LRB- IGF-2 -RRB- in Philadelphia_chromosome_negative_chronic_myeloproliferative_disorders .
15661221	0	IGF-2	35,40	insulin-like_growth_factor-2	5,33	IGF-2	insulin-like growth factor-2	3481	3481	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	High insulin-like_growth_factor-2 -LRB- IGF-2 -RRB- gene expression is an independent predictor of poor survival for patients with advanced stage serous_epithelial_ovarian_cancer .
8743420	0	IGF-BP2	78,85	IGF-1	44,49	IGF-BP2	IGF-1	25662(Tax:10116)	24482(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF-binding_protein_2 -LRB- IGF-BP2 -RRB- in the hippocampus following cytotoxic lesion of the dentate gyrus .
12855191	0	IGF-I	49,54	14-3-3_eta	19,29	IGF-I	14-3-3 eta	16000(Tax:10090)	22629(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of 14-3-3_eta gene expression by IGF-I in mouse cerebellum during postnatal development .
11139436	0	IGF-I	88,93	ACE	31,34	IGF-I	ACE	24482(Tax:10116)	24310(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Angiotensin-converting enzyme -LRB- ACE -RRB- inhibition attenuates insulin-like_growth_factor-I -LRB- IGF-I -RRB- induced cardiac fibroblast proliferation .
11179063	0	IGF-I	0,5	Bcl-xL	31,37	IGF-I	Bcl-xL	24482(Tax:10116)	24888(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IGF-I differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart .
15195991	0	IGF-I	46,51	DHEA-S	89,95	IGF-I	DHEA-S	3479	6822	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Serum levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- , and their relationships with serum interleukin-6 , in the geriatric syndrome of frailty .
2559767	0	IGF-I	45,50	EGF	81,84	IGF-I	EGF	3479	1950	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	-LSB- Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- and epidermal_growth_factor -LRB- EGF -RRB- receptors in primary non-glial human brain_tumors -RSB- .
26899323	0	IGF-I	0,5	ERb	17,20	IGF-I	ERb	3479	2100	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	IGF-I stimulates ERb and aromatase expression via IGF1R/PI3K/AKT-mediated transcriptional activation in endometriosis .
24677183	0	IGF-I	40,45	EphB4	10,15	IGF-I	EphB4	16000(Tax:10090)	13846(Tax:10090)	Gene	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	Ephrin_B2 / EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation .
11401402	0	IGF-I	0,5	FGF-2	22,27	IGF-I	FGF-2	16000(Tax:10090)	14173(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IGF-I synergizes with FGF-2 to stimulate oligodendrocyte progenitor entry into the cell cycle .
11249917	0	IGF-I	70,75	GH	32,34	IGF-I	GH	3479	2688	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Correlations of growth_hormone -LRB- GH -RRB- and insulin-like_growth_factor_I -LRB- IGF-I -RRB- : effects of exercise and abuse by athletes .
12110529	0	IGF-I	14,19	GH	28,30	IGF-I	GH	443318(Tax:9940)	443329(Tax:9940)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Regulation of IGF-I mRNA by GH : putative functions for class 1 and 2 message .
8612531	0	IGF-I	64,69	GH	87,89	IGF-I	GH	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	growth_hormone|appos|START_ENTITY growth_hormone|appos|END_ENTITY	Differential long-term effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- growth_hormone -LRB- GH -RRB- , and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats .
16614389	0	IGF-I	81,86	GH_receptor	57,68	IGF-I	GH receptor	16000(Tax:10090)	2690	Gene	Gene	production|dep|START_ENTITY production|compound|END_ENTITY	A GH_receptor antisense oligonucleotide inhibits hepatic GH_receptor expression , IGF-I production and body weight_gain in normal mice .
25607339	0	IGF-I	10,15	Growth_Hormone	53,67	IGF-I	Growth Hormone	3479	2688	Gene	Gene	Deficiency|compound|START_ENTITY Deficiency|nmod|Factor Factor|nmod|Therapy Therapy|compound|END_ENTITY	Secondary IGF-I Deficiency as a Prognostic Factor of Growth_Hormone -LRB- GH -RRB- Therapy Effectiveness in Children with Isolated , Non-acquired GH_Deficiency .
12898266	0	IGF-I	47,52	Growth_hormone	0,14	IGF-I	Growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY obtain|dobj|levels titrated|xcomp|obtain substitution|acl|titrated substitution|amod|END_ENTITY	Growth_hormone substitution titrated to obtain IGF-I levels in the physiological range in hypopituitary adults : effects upon dynamic strength , endurance and EMG .
1360928	0	IGF-I	88,93	Growth_hormone	0,14	IGF-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY receptor|appos|insulin-like_growth_factor-I stimulate|dobj|receptor stimulate|nsubj|END_ENTITY	Growth_hormone and prolactin stimulate androgen receptor , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor levels in the prostate of immature rats .
15163339	0	IGF-I	16,21	Growth_hormone	0,14	IGF-I	Growth hormone	3479	2688	Gene	Gene	peritoneal_dialysis|nsubj|START_ENTITY peritoneal_dialysis|advmod|END_ENTITY	Growth_hormone , IGF-I and its binding proteins -LRB- IGFBP-1_and _ -3 -RRB- in adult uraemic patients undergoing peritoneal_dialysis and haemodialysis .
2082191	0	IGF-I	199,204	Growth_hormone	0,14	IGF-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	interplay|nmod|START_ENTITY regulation|dep|interplay regulation|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- regulation of cytochrome P-450IIC12 , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , and GH_receptor messenger RNA expression in primary rat hepatocytes : a hormonal interplay with insulin , IGF-I , and thyroid hormone .
21846964	0	IGF-I	15,20	Growth_hormone	0,14	IGF-I	Growth hormone	3479	2688	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Growth_hormone / IGF-I axis and growth_hormone receptor mutations in idiopathic short_stature .
26682747	0	IGF-I	35,40	Growth_hormone	0,14	IGF-I	Growth hormone	3479	2688	Gene	Gene	response|amod|START_ENTITY relates|nsubj|response relates|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- dose-dependent IGF-I response relates to pubertal height gain .
7528707	0	IGF-I	61,66	Growth_hormone	0,14	IGF-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY stimulates|dobj|insulin-like_growth_factor-I stimulates|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- stimulates insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein _ -LRB- IGFBP -RRB- -2 gene expression in spleens of juvenile rats .
7564093	0	IGF-I	72,77	Growth_hormone	0,14	IGF-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	expressions|nmod|START_ENTITY regulate|dobj|expressions interact|xcomp|regulate interact|nsubj|END_ENTITY	Growth_hormone and nutrition interact to regulate expressions of kidney IGF-I and IGFBP mRNAs .
7711889	0	IGF-I	60,65	Growth_hormone	0,14	IGF-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY modulates|dobj|insulin-like_growth_factor_I modulates|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- modulates insulin-like_growth_factor_I -LRB- IGF-I -RRB- and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats .
8262319	0	IGF-I	83,88	Growth_hormone	0,14	IGF-I	Growth hormone	3479	2688	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Growth_hormone induces resistance to the mitogenic action of insulin through local IGF-I .
8550769	0	IGF-I	189,194	Growth_hormone	0,14	IGF-I	Growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY induce|dobj|insulin-like_growth_factor-I secretory|parataxis|induce secretory|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- secretory dynamics in a case of acromegalic_gigantism associated with hyperprolactinemia : nonpulsatile secretion of GH may induce elevated insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 levels .
8824894	0	IGF-I	25,30	Growth_hormone	0,14	IGF-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Growth_hormone increases IGF-I , collagen I and collagen III gene expression in dwarf rat skeletal muscle .
9364353	0	IGF-I	110,115	Growth_hormone	0,14	IGF-I	Growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY effect|nmod|levels treatment|dep|effect treatment|amod|END_ENTITY	Growth_hormone treatment in growth_retarded children with end stage_renal_failure : effect on free/dissociable IGF-I levels .
9390955	0	IGF-I	15,20	Growth_hormone	0,14	IGF-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	exercise|nummod|START_ENTITY maintains|nsubj|exercise END_ENTITY|parataxis|maintains	Growth_hormone / IGF-I and/or resistive exercise maintains myonuclear number in hindlimb unweighted muscles .
11925461	0	IGF-I	43,48	IGF-I	76,81	IGF-I	IGF-I	397491(Tax:9823)	397491(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression END_ENTITY|nsubj|regulation	Differential regulation of porcine hepatic IGF-I mRNA expression and plasma IGF-I concentration by a low lysine diet .
11925461	0	IGF-I	76,81	IGF-I	43,48	IGF-I	IGF-I	397491(Tax:9823)	397491(Tax:9823)	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of porcine hepatic IGF-I mRNA expression and plasma IGF-I concentration by a low lysine diet .
16195401	0	IGF-I	157,162	IGF-I	189,194	IGF-I	IGF-I	3479	3479	Gene	Gene	START_ENTITY|nmod|action action|amod|END_ENTITY	Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action .
16195401	0	IGF-I	189,194	IGF-I	157,162	IGF-I	IGF-I	3479	3479	Gene	Gene	action|amod|START_ENTITY END_ENTITY|nmod|action	Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action .
22363152	0	IGF-I	10,15	IGF-I	74,79	IGF-I	IGF-I	3479	3479	Gene	Gene	Effect|nmod|START_ENTITY Related|nsubj|Effect Related|nmod|Effect Effect|nmod|END_ENTITY	Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B .
22363152	0	IGF-I	74,79	IGF-I	10,15	IGF-I	IGF-I	3479	3479	Gene	Gene	Effect|nmod|START_ENTITY Related|nmod|Effect Related|nsubj|Effect Effect|nmod|END_ENTITY	Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B .
22626778	0	IGF-I	73,78	IGF-I	87,92	IGF-I	IGF-I	3479	3479	Gene	Gene	Effect|appos|START_ENTITY Effect|appos|END_ENTITY	Effect of dietary energy on seminal plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- , serum IGF-I and testosterone levels , semen quality and fertility in adult rams .
22626778	0	IGF-I	87,92	IGF-I	73,78	IGF-I	IGF-I	3479	3479	Gene	Gene	Effect|appos|START_ENTITY Effect|appos|END_ENTITY	Effect of dietary energy on seminal plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- , serum IGF-I and testosterone levels , semen quality and fertility in adult rams .
2624779	0	IGF-I	117,122	IGF-I	144,149	IGF-I	IGF-I	100135551(Tax:10141)	100135551(Tax:10141)	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Similar hormonal changes in sera from scorbutic and fasted -LRB- vitamin_C-supplemented -RRB- guinea_pigs , including decreased IGF-I and appearance of an IGF-I reversible mitogenic inhibitor .
8958789	0	IGF-I	25,30	IGF-I	43,48	IGF-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Reduction in circulating IGF-I and hepatic IGF-I mRNA levels after caecal_ligation_and_puncture are associated with differential regulation of hepatic IGF-binding_protein-1 , _ -2 _ and _ -3 mRNA levels .
8958789	0	IGF-I	43,48	IGF-I	25,30	IGF-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Reduction in circulating IGF-I and hepatic IGF-I mRNA levels after caecal_ligation_and_puncture are associated with differential regulation of hepatic IGF-binding_protein-1 , _ -2 _ and _ -3 mRNA levels .
9640414	0	IGF-I	11,16	IGF-I	24,29	IGF-I	IGF-I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Serum free IGF-I , total IGF-I , IGFBP-1 and IGFBP-3 levels in an elderly population : relation to age and sex steroid levels .
9640414	0	IGF-I	24,29	IGF-I	11,16	IGF-I	IGF-I	3479	3479	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Serum free IGF-I , total IGF-I , IGFBP-1 and IGFBP-3 levels in an elderly population : relation to age and sex steroid levels .
9920066	0	IGF-I	41,46	IGF-I	55,60	IGF-I	IGF-I	3479	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Serum free insulin-like_growth_factor_I -LRB- IGF-I -RRB- , total IGF-I , and IGF-binding_protein-3 concentrations in normal children and children with growth_hormone_deficiency .
9920066	0	IGF-I	55,60	IGF-I	41,46	IGF-I	IGF-I	3479	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Serum free insulin-like_growth_factor_I -LRB- IGF-I -RRB- , total IGF-I , and IGF-binding_protein-3 concentrations in normal children and children with growth_hormone_deficiency .
11095464	0	IGF-I	46,51	IGF-II	54,60	IGF-I	IGF-II	3479	3481	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , IGF-binding_protein-3 , and prostate-specific_antigen as predictors of clinical prostate_cancer .
15302390	0	IGF-I	54,59	IGF-II	61,67	IGF-I	IGF-II	443318(Tax:9940)	443325(Tax:9940)	Gene	Gene	I|compound|START_ENTITY I|dep|END_ENTITY	Co-expression of messenger ribonucleic acids encoding IGF-I , IGF-II , type I and II IGF receptors and IGF-binding proteins -LRB- IGFBP-1 to -6 -RRB- during follicular development in the ovary of seasonally anoestrous ewes .
20553076	0	IGF-I	53,58	IGF-II	60,66	IGF-I	IGF-II	3479	3481	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Associations of food and nutrient intakes with serum IGF-I , IGF-II , IGFBP-3 , TGF-b1 , total SOD activity and sFas levels among middle-aged Japanese : the Japan Collaborative Cohort study .
22776750	0	IGF-I	35,40	IGF-II	42,48	IGF-I	IGF-II	3479	3481	Gene	Gene	AMH|compound|START_ENTITY AMH|appos|END_ENTITY	Follicular fluid concentrations of IGF-I , IGF-II , IGFBP-3 , VEGF , AMH , and inhibin-B in women undergoing controlled ovarian_hyperstimulation using GnRH agonist or GnRH antagonist .
7543116	0	IGF-I	140,145	IGF-II	147,153	IGF-I	IGF-II	3479	3481	Gene	Gene	index|amod|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
8624976	0	IGF-I	15,20	IGF-II	21,27	IGF-I	IGF-II	3479	3481	Gene	Gene	insulin|appos|START_ENTITY END_ENTITY|nsubj|insulin	Serum insulin , IGF-I , IGF-II and growth_hormone , and left ventricular mass in noninsulin-dependent mellitus .
8667333	0	IGF-I	30,35	IGF-II_and_type-I_IGF_receptor	38,68	IGF-I	IGF-II and type-I IGF receptor	3479	3481	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II_and_type-I_IGF_receptor gene expression in the ovary of the laying hen .
11507082	0	IGF-I	161,166	IGF-IR	188,194	IGF-I	IGF-IR	3479	3480	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	In vivo progression of LAPC-9 and LNCaP prostate_cancer models to androgen independence is associated with increased expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-I_receptor -LRB- IGF-IR -RRB- .
23950756	0	IGF-I	0,5	IGF-I_Receptor	96,110	IGF-I	IGF-I Receptor	16000(Tax:10090)	16001(Tax:10090)	Gene	Gene	Stimulate|nsubj|START_ENTITY Stimulate|advcl|Binding Binding|nmod|END_ENTITY	IGF-I , IGF-II , and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I_Receptor .
10583412	0	IGF-I	30,35	IGF-I_receptor	126,140	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	Insulin-like_growth_factor-I|appos|START_ENTITY Insulin-like_growth_factor-I|dep|activation activation|nmod|kinase kinase|dep|occurs occurs|nmod|activation activation|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- - dependent activation of pp42/44 mitogen-activated_protein kinase occurs independently of IGF-I_receptor kinase activation and IRS-1 tyrosine phosphorylation .
11245675	0	IGF-I	30,35	IGF-I_receptor	129,143	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	Insulin-like_growth_factor_I|appos|START_ENTITY protects|nsubj|Insulin-like_growth_factor_I protects|nmod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- protects cells from apoptosis by Alzheimer 's V642I mutant amyloid_precursor_protein through IGF-I_receptor in an IGF-binding protein-sensitive manner .
14691011	0	IGF-I	105,110	IGF-I_receptor	112,126	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY Inhibition|nmod|insulin-like_growth_factor_I Inhibition|parataxis|circuit circuit|amod|END_ENTITY	Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like_growth_factor_I -LRB- IGF-I -RRB- / IGF-I_receptor autocrine circuit .
14723884	0	IGF-I	64,69	IGF-I_receptor	71,85	IGF-I	IGF-I receptor	104978413	281848(Tax:9913)	Gene	Gene	somatotropin|nmod|START_ENTITY effects|nmod|somatotropin effects|appos|END_ENTITY	The effects of recombinant bovine somatotropin -LRB- rbST -RRB- on tissue IGF-I , IGF-I_receptor , and GH mRNA levels in rainbow_trout , Oncorhynchus_mykiss .
16728156	0	IGF-I	94,99	IGF-I_receptor	125,139	IGF-I	IGF-I receptor	104978413	281848(Tax:9913)	Gene	Gene	Stimulation|appos|START_ENTITY mediated|nsubjpass|Stimulation mediated|nmod|END_ENTITY	Stimulation of the development of bovine embryos by insulin_and_insulin-like_growth_factor-I -LRB- IGF-I -RRB- is mediated through the IGF-I_receptor .
17761895	0	IGF-I	101,106	IGF-I_receptor	20,34	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	effects|nmod|START_ENTITY highlights|dobj|effects highlights|nsubj|Inactivation Inactivation|nmod|gene gene|amod|END_ENTITY	Inactivation of the IGF-I_receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I .
17945524	0	IGF-I	0,5	IGF-I_receptor	21,35	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	IGF-I binding to the IGF-I_receptor is affected by contaminants in commercial BSA : the contaminants are proteins with IGF-I binding properties .
17945524	0	IGF-I	118,123	IGF-I_receptor	21,35	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	properties|amod|START_ENTITY proteins|nmod|properties affected|parataxis|proteins affected|nsubjpass|binding binding|nmod|END_ENTITY	IGF-I binding to the IGF-I_receptor is affected by contaminants in commercial BSA : the contaminants are proteins with IGF-I binding properties .
21799000	0	IGF-I	0,5	IGF-I_receptor	53,67	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|interaction interaction|nmod|END_ENTITY	IGF-I stimulates cooperative interaction between the IGF-I_receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells .
2580525	0	IGF-I	77,82	IGF-I_receptor	49,63	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|antibodies antibodies|nmod|END_ENTITY	Characterization of monoclonal antibodies to the IGF-I_receptor that inhibit IGF-I binding to human cells .
25947141	0	IGF-I	92,97	IGF-I_receptor	23,37	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	changes|nmod|START_ENTITY parallel|dobj|changes parallel|nsubj|Changes Changes|acl|circulating circulating|dobj|activity activity|amod|END_ENTITY	Changes in circulating IGF-I_receptor stimulating activity do not parallel changes in Total IGF-I during GH treatment of GH-deficient adults .
7505467	0	IGF-I	30,35	IGF-I_receptor	70,84	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-like growth factor-I -LRB- IGF-I -RRB- dependent phosphorylation of the IGF-I_receptor in MG-63 cells .
7514345	0	IGF-I	31,36	IGF-I_receptor	54,68	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	interaction|nmod|START_ENTITY Analysis|nmod|interaction analogs|nsubj|Analysis analogs|nmod|END_ENTITY	Analysis of the interaction of IGF-I analogs with the IGF-I_receptor and IGF binding proteins .
7522208	0	IGF-I	61,66	IGF-I_receptor	85,99	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	Analysis|appos|START_ENTITY analogs|nsubj|Analysis analogs|nmod|proteins proteins|compound|END_ENTITY	Analysis of the interaction of insulin-like_growth_factor_I -LRB- IGF-I -RRB- analogs with the IGF-I_receptor and IGF-binding proteins .
7544271	0	IGF-I	59,64	IGF-I_receptor	163,177	IGF-I	IGF-I receptor	104978413	281848(Tax:9913)	Gene	Gene	START_ENTITY|advcl|stimulating stimulating|nmod|cells cells|dep|interaction interaction|nmod|proteins proteins|compound|END_ENTITY	Insulin-like_growth_factor_II _ -LRB- IGF-II -RRB- is more potent than IGF-I in stimulating cortisol secretion from cultured bovine adrenocortical cells : interaction with the IGF-I_receptor and IGF-binding proteins .
8188767	0	IGF-I	77,82	IGF-I_receptor	241,255	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY /|nsubj|insulin-like_growth_factor-I /|dep|stimulation stimulation|nmod|IGF-II IGF-II|nmod|END_ENTITY	Human_osteosarcoma -LRB- U-2_OS -RRB- cells express both insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors and insulin-like_growth_factor-II / mannose-6-phosphate -LRB- IGF-II/M6P -RRB- receptors and synthesize IGF-II : autocrine growth stimulation by IGF-II via the IGF-I_receptor .
8722694	0	IGF-I	0,5	IGF-I_receptor	70,84	IGF-I	IGF-I receptor	16000(Tax:10090)	16001(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|blastocysts blastocysts|nmod|END_ENTITY	IGF-I and insulin regulate glucose transport in mouse blastocysts via IGF-I_receptor .
9721859	0	IGF-I	45,50	IGF-I_receptor	95,109	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|dep|proliferation proliferation|nmod|number number|amod|END_ENTITY	Src stimulates insulin-like_growth_factor_I -LRB- IGF-I -RRB- - dependent cell proliferation by increasing IGF-I_receptor number in human pancreatic_carcinoma cells .
9846170	0	IGF-I	105,110	IGF-I_receptor	212,226	IGF-I	IGF-I receptor	3479	3480	Gene	Gene	factors|dep|START_ENTITY steroidogenesis|nmod|factors Regulation|nmod|steroidogenesis enhance|nsubj|Regulation enhance|nmod|interaction interaction|nmod|proteins proteins|compound|END_ENTITY	Regulation of steroidogenesis by insulin-like growth factors -LRB- IGFs -RRB- in adult human adrenocortical cells : IGF-I and , more potently , IGF-II preferentially enhance androgen biosynthesis through interaction with the IGF-I_receptor and IGF-binding proteins .
9768663	0	IGF-I	39,44	IGF-binding_protein-1	47,68	IGF-I	IGF-binding protein-1	3479	3484	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Insulin , insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-1 , growth_hormone , and feeding in the newborn .
15126555	0	IGF-I	97,102	IGF-binding_protein-3	105,126	IGF-I	IGF-binding protein-3	3479	3486	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Sustained elevation of pulsatile growth_hormone -LRB- GH -RRB- secretion and insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women .
18780604	0	IGF-I	36,41	IGF-binding_protein-3	44,65	IGF-I	IGF-binding protein-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-3 , and growth_hormone levels in collodion babies : a case-control study .
7530256	0	IGF-I	41,46	IGF-binding_protein-3	49,70	IGF-I	IGF-binding protein-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Changes in insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-3 , growth hormone -LRB- GH -RRB- - binding protein , erythrocyte IGF-I_receptors , and growth rate during GH treatment .
20610598	0	IGF-I	36,41	IGF-binding_proteins_2_and_3	44,72	IGF-I	IGF-binding proteins 2 and 3	3479	3485;3486	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_proteins_2_and_3 , and the risk for development of malignancies in adults with growth_hormone -LRB- GH -RRB- deficiency treated with GH : data from KIMS -LRB- Pfizer International Metabolic Database -RRB- .
10088650	0	IGF-I	183,188	IGFBP-1	76,83	IGF-I	IGFBP-1	16000(Tax:10090)	16006(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY studies|nmod|transgenic_mice Insulin-like_growth_factor-I|dep|studies Insulin-like_growth_factor-I|acl:relcl|exacerbates exacerbates|nsubj|ameliorates ameliorates|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- ameliorates and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- exacerbates the effects of undernutrition on brain growth during early postnatal life : studies in IGF-I and IGFBP-1 transgenic_mice .
10088650	0	IGF-I	30,35	IGFBP-1	76,83	IGF-I	IGFBP-1	16000(Tax:10090)	16006(Tax:10090)	Gene	Gene	Insulin-like_growth_factor-I|appos|START_ENTITY Insulin-like_growth_factor-I|acl:relcl|exacerbates exacerbates|nsubj|ameliorates ameliorates|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- ameliorates and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- exacerbates the effects of undernutrition on brain growth during early postnatal life : studies in IGF-I and IGFBP-1 transgenic_mice .
10350456	0	IGF-I	68,73	IGFBP-1	120,127	IGF-I	IGFBP-1	3479	3484	Gene	Gene	mutagenesis|appos|START_ENTITY identifies|nsubj|mutagenesis identifies|dobj|epitopes epitopes|nmod|END_ENTITY	Total alanine-scanning mutagenesis of insulin-like_growth_factor_I -LRB- IGF-I -RRB- identifies differential binding epitopes for IGFBP-1 and IGFBP-3 .
10990444	0	IGF-I	106,111	IGFBP-1	113,120	IGF-I	IGFBP-1	3479	3484	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Insulin-like growth factor I receptors on blood cells : their relationship to circulating total and `` free '' IGF-I , IGFBP-1 , IGFBP-3 and insulin levels in healthy subjects .
11579061	0	IGF-I	91,96	IGFBP-1	123,130	IGF-I	IGFBP-1	3479	3484	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY competition|nmod|insulin-like_growth_factor_I Effects|nmod|competition Effects|amod|END_ENTITY	Effects of an endurance cycling competition on resting serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and its binding proteins IGFBP-1 and IGFBP-3 .
11928553	0	IGF-I	40,45	IGFBP-1	72,79	IGF-I	IGFBP-1	3479	3484	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	Function of insulin-like_growth_factor -LRB- IGF-I -RRB- and its binding protein -LRB- IGFBP-1 -RRB- in pathological proliferation of endometrium .
11994360	0	IGF-I	0,5	IGFBP-1	57,64	IGF-I	IGFBP-1	3479	3484	Gene	Gene	phosphoisoforms|nsubj|START_ENTITY phosphoisoforms|nmod|growth growth|amod|END_ENTITY	IGF-I , IGF_binding_protein _ -LRB- IGFBP -RRB- -3 , phosphoisoforms of IGFBP-1 , and postnatal growth in very low birth weight infants .
15302390	0	IGF-I	54,59	IGFBP-1	123,130	IGF-I	IGFBP-1	443318(Tax:9940)	443132(Tax:9940)	Gene	Gene	I|compound|START_ENTITY I|dep|END_ENTITY	Co-expression of messenger ribonucleic acids encoding IGF-I , IGF-II , type I and II IGF receptors and IGF-binding proteins -LRB- IGFBP-1 to -6 -RRB- during follicular development in the ovary of seasonally anoestrous ewes .
15713723	0	IGF-I	71,76	IGFBP-1	102,109	IGF-I	IGFBP-1	3479	3484	Gene	Gene	I|appos|START_ENTITY I|appos|IGF_binding_protein_1 IGF_binding_protein_1|appos|END_ENTITY	Testosterone and estradiol regulate free insulin-like growth factor I -LRB- IGF-I -RRB- , IGF_binding_protein_1 -LRB- IGFBP-1 -RRB- , and dimeric IGF-I/IGFBP -1 concentrations .
20155489	0	IGF-I	138,143	IGFBP-1	74,81	IGF-I	IGFBP-1	3479	3484	Gene	Gene	levels|amod|START_ENTITY serum|dobj|levels factor-binding|advcl|serum factor-binding|dobj|protein protein|appos|END_ENTITY	Common_genetic_variation_of_insulin-like_growth factor-binding protein 1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and acid labile subunit in relation to serum IGF-I levels and mammographic density .
20672288	0	IGF-I	85,90	IGFBP-1	64,71	IGF-I	IGFBP-1	3479	3484	Gene	Gene	START_ENTITY|nsubj|Polymerization Polymerization|nmod|potentiates potentiates|appos|END_ENTITY	Polymerization of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- potentiates IGF-I actions in placenta .
26380917	0	IGF-I	71,76	IGFBP-1	0,7	IGF-I	IGFBP-1	3479	3484	Gene	Gene	women|nmod|START_ENTITY predicts|nmod|women predicts|nsubj|END_ENTITY	IGFBP-1 predicts all-cause mortality in elderly women independently of IGF-I .
7472488	0	IGF-I	49,54	IGFBP-1	122,129	IGF-I	IGFBP-1	16000(Tax:10090)	16006(Tax:10090)	Gene	Gene	factor-I|appos|START_ENTITY actions|nmod|factor-I studies|nmod|actions studies|nmod|transgenic_mice transgenic_mice|appos|END_ENTITY	In vivo actions of insulin-like growth factor-I -LRB- IGF-I -RRB- on brain myelination : studies of IGF-I and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- transgenic_mice .
7472488	0	IGF-I	89,94	IGFBP-1	122,129	IGF-I	IGFBP-1	16000(Tax:10090)	16006(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|appos|END_ENTITY	In vivo actions of insulin-like growth factor-I -LRB- IGF-I -RRB- on brain myelination : studies of IGF-I and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- transgenic_mice .
7543116	0	IGF-I	140,145	IGFBP-1	155,162	IGF-I	IGFBP-1	3479	3484	Gene	Gene	index|amod|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
8784106	0	IGF-I	206,211	IGFBP-1	94,101	IGF-I	IGFBP-1	3479	3484	Gene	Gene	I|appos|START_ENTITY production|dep|I I|nmod|production I|appos|END_ENTITY	Insulin-like growth factor II -LRB- IGF-II -RRB- inhibits insulin-like growth factor binding protein I -LRB- IGFBP-1 -RRB- production in luteinized human granulosa cells with a potency similar to insulin-like growth factor I -LRB- IGF-I -RRB- and higher than insulin .
9497875	0	IGF-I	116,121	IGFBP-1	62,69	IGF-I	IGFBP-1	3479	3484	Gene	Gene	infusion|appos|START_ENTITY infusion|nmod|subunit subunit|compound|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9497875	0	IGF-I	41,46	IGFBP-1	62,69	IGF-I	IGFBP-1	3479	3484	Gene	Gene	infusion|nmod|START_ENTITY infusion|nmod|subunit subunit|compound|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9555872	0	IGF-I	119,124	IGFBP-1	149,156	IGF-I	IGFBP-1	3479	3484	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY association|nmod|insulin-like_growth_factor-I change|dep|association change|parataxis|axis axis|nsubj|IGF-binding_protein-1 IGF-binding_protein-1|appos|END_ENTITY	Alcohol withdrawal-induced change in lipoprotein -LRB- a -RRB- : association with the growth_hormone / insulin-like_growth_factor-I -LRB- IGF-I -RRB- / IGF-binding_protein-1 -LRB- IGFBP-1 -RRB- axis .
25787077	0	IGF-I	66,71	IGFBP-2	123,130	IGF-I	IGFBP-2	16000(Tax:10090)	16008(Tax:10090)	Gene	Gene	Insulin-Like_Growth_Factor-I|appos|START_ENTITY Insulin-Like_Growth_Factor-I|appos|END_ENTITY	The Coordinate Cellular Response to Insulin-Like_Growth_Factor-I -LRB- IGF-I -RRB- and Insulin-Like_Growth_Factor_Binding_Protein-2 -LRB- IGFBP-2 -RRB- Is Regulated Through Vimentin Binding to Receptor_Tyrosine_Phosphatase_b -LRB- RPTPb -RRB- .
7543116	0	IGF-I	140,145	IGFBP-2	164,171	IGF-I	IGFBP-2	3479	3485	Gene	Gene	index|amod|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
10668288	0	IGF-I	62,67	IGFBP-3	98,105	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	-LSB- Usefulness of the measurement of insulin-like_growth_factor -LRB- IGF-I -RRB- and IGF-1_binding_protein-3 -LRB- IGFBP-3 -RRB- for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in children -RSB- .
10700718	0	IGF-I	31,36	IGFBP-3	61,68	IGF-I	IGFBP-3	3479	3486	Gene	Gene	serum|nummod|START_ENTITY efficiency|nmod|serum efficiency|appos|END_ENTITY	Diagnostic efficiency of serum IGF-I , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and urinary GH measurements in the diagnosis of adult_GH_deficiency : importance of an appropriate reference population .
10703534	0	IGF-I	30,35	IGFBP-3	64,71	IGF-I	IGFBP-3	3479	3486	Gene	Gene	Insulin-like_growth_factor-I|dep|START_ENTITY Insulin-like_growth_factor-I|dep|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- concentrations compared to stimulated growth_hormone -LRB- GH -RRB- in the evaluation of children treated for malignancy .
10856880	0	IGF-I	70,75	IGFBP-3	46,53	IGF-I	IGFBP-3	3479	3486	Gene	Gene	action|amod|START_ENTITY effects|nmod|action effects|amod|END_ENTITY	Differential effects of IGF-binding proteins , IGFBP-3 and IGFBP-5 , on IGF-I action and binding to cell membranes of immortalized human chondrocytes .
10971450	0	IGF-I	47,52	IGFBP-3	78,85	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|IGF_binding_protein-3 IGF_binding_protein-3|appos|END_ENTITY	Monitoring serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and leptin during growth hormone treatment for disordered growth .
11592569	0	IGF-I	55,60	IGFBP-3	85,92	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Maternal and fetal serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , leptin levels and early postnatal growth in infants born asymmetrically small for gestational age .
14674122	0	IGF-I	90,95	IGFBP-3	63,70	IGF-I	IGFBP-3	3479	3486	Gene	Gene	-RSB-|amod|START_ENTITY depends|nsubj|-RSB- impact|parataxis|depends impact|nmod|secretion secretion|nmod|END_ENTITY	The impact of progesterone on simultaneous , local secretion of IGFBP-3 and IGF-I -LSB- IGFBP-3 / IGF-I index -RSB- by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype .
14974910	0	IGF-I	10,15	IGFBP-3	18,25	IGF-I	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Increased IGF-I : IGFBP-3 ratio in patients with hepatocellular_carcinoma .
15126555	0	IGF-I	97,102	IGFBP-3	128,135	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|IGF-binding_protein-3 IGF-binding_protein-3|appos|END_ENTITY	Sustained elevation of pulsatile growth_hormone -LRB- GH -RRB- secretion and insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women .
15259383	0	IGF-I	99,104	IGFBP-3	133,140	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Reference ranges for two automated chemiluminescent assays for serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein_3 -LRB- IGFBP-3 -RRB- .
15270408	0	IGF-I	82,87	IGFBP-3	89,96	IGF-I	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|dep|ALS ALS|compound|END_ENTITY	Alterations in serum growth_hormone -LRB- GH -RRB- / GH dependent ternary complex components -LRB- IGF-I , IGFBP-3 , ALS , IGF-I/IGFBP -3 molar ratio -RRB- and the influence of these alterations on growth pattern in female rhythmic gymnasts .
15342444	0	IGF-I	73,78	IGFBP-3	107,114	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Dietary and lifestyle correlates of plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- : the multiethnic cohort .
15641262	0	IGF-I	75,80	IGFBP-3	109,116	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Influence of iodine supplementation on serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- levels in severe_iodine_deficiency .
16210470	0	IGF-I	89,94	IGFBP-3	27,34	IGF-I	IGFBP-3	3479	3486	Gene	Gene	response|nmod|START_ENTITY determines|dobj|response determines|nsubj|regulation regulation|nmod|END_ENTITY	EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I .
17044083	0	IGF-I	39,44	IGFBP-3	116,123	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|dep|START_ENTITY association|amod|insulin-like_growth_factor-I dependent|nsubj|association dependent|nmod|interaction interaction|appos|END_ENTITY	Enhanced insulin-like_growth_factor-I -LRB- IGF-I -RRB- cell association at reduced pH is dependent on IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- interaction .
17113804	0	IGF-I	36,41	IGFBP-3	66,73	IGF-I	IGFBP-3	3479	3486	Gene	Gene	IGF_binding_protein-3|appos|START_ENTITY IGF_binding_protein-3|appos|END_ENTITY	Serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- and leptin levels are related to abdominal aortic intima-media thickness in macrosomic newborns .
1720092	0	IGF-I	108,113	IGFBP-3	160,167	IGF-I	IGFBP-3	104978413	3486	Gene	Gene	action|amod|START_ENTITY potentiation|nmod|action potentiation|dep|evidence evidence|nmod|processing processing|nmod|END_ENTITY	Glycosylation of insulin-like growth factor binding protein-3 -LRB- IGFBP-3 -RRB- is not required for potentiation of IGF-I action : evidence for processing of cell-bound IGFBP-3 .
1720092	0	IGF-I	108,113	IGFBP-3	63,70	IGF-I	IGFBP-3	104978413	3486	Gene	Gene	action|amod|START_ENTITY potentiation|nmod|action required|nmod|potentiation required|nsubjpass|Glycosylation Glycosylation|nmod|factor factor|appos|END_ENTITY	Glycosylation of insulin-like growth factor binding protein-3 -LRB- IGFBP-3 -RRB- is not required for potentiation of IGF-I action : evidence for processing of cell-bound IGFBP-3 .
17395977	0	IGF-I	6,11	IGFBP-3	40,47	IGF-I	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|appos|protein protein|appos|END_ENTITY	Serum IGF-I , its major binding protein -LRB- IGFBP-3 -RRB- and epithelial_ovarian_cancer risk : the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- .
17984239	2	IGF-I	629,634	IGFBP-3	636,643	IGF-I	IGFBP-3	3479	3486	Gene	Gene	assays|amod|START_ENTITY assays|appos|END_ENTITY	OBJECTIVE : We evaluated the agreement between different IGF-I -LRB- IGFBP-3 -RRB- assays in predicting GH_deficiency and tested whether variability between growth factor screening and pharmacological testing could be diminished by reassessment of growth factor and GH peak concentrations in a single laboratory .
20155489	0	IGF-I	138,143	IGFBP-3	84,91	IGF-I	IGFBP-3	3479	3486	Gene	Gene	levels|amod|START_ENTITY serum|dobj|levels factor-binding|advcl|serum factor-binding|dobj|protein protein|appos|END_ENTITY	Common_genetic_variation_of_insulin-like_growth factor-binding protein 1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and acid labile subunit in relation to serum IGF-I levels and mammographic density .
20553076	0	IGF-I	53,58	IGFBP-3	68,75	IGF-I	IGFBP-3	3479	3486	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Associations of food and nutrient intakes with serum IGF-I , IGF-II , IGFBP-3 , TGF-b1 , total SOD activity and sFas levels among middle-aged Japanese : the Japan Collaborative Cohort study .
20553077	0	IGF-I	83,88	IGFBP-3	117,124	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Time spent walking or exercising and blood levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- : A large-scale cross-sectional study in the Japan Collaborative Cohort study .
21536469	0	IGF-I	186,191	IGFBP-3	68,75	IGF-I	IGFBP-3	3479	3486	Gene	Gene	levels|nmod|START_ENTITY binding|nmod|levels binding|dobj|polymorphism polymorphism|amod|protein-3 protein-3|dep|END_ENTITY	Relationship_of_insulin-like_growth factor -LRB- IGF -RRB- binding protein-3 -LRB- IGFBP-3 -RRB- gene polymorphism with the susceptibility to development of prostate_cancer and influence on serum levels of IGF-I , and IGFBP-3 .
21670726	0	IGF-I	45,50	IGFBP-3	52,59	IGF-I	IGFBP-3	3479	3486	Gene	Gene	IGFBP-2|dep|START_ENTITY IGFBP-2|dep|END_ENTITY	Overexpression of P53 protein and local hGH , IGF-I , IGFBP-3 , IGFBP-2 and PRL secretion by human breast_cancer explants .
22776750	0	IGF-I	35,40	IGFBP-3	50,57	IGF-I	IGFBP-3	3479	3486	Gene	Gene	AMH|compound|START_ENTITY AMH|appos|END_ENTITY	Follicular fluid concentrations of IGF-I , IGF-II , IGFBP-3 , VEGF , AMH , and inhibin-B in women undergoing controlled ovarian_hyperstimulation using GnRH agonist or GnRH antagonist .
23174226	0	IGF-I	129,134	IGFBP-3	67,74	IGF-I	IGFBP-3	3479	3486	Gene	Gene	risk|nmod|START_ENTITY gene|nmod|risk gene|compound|END_ENTITY	The influence of promoter -202 _ A/C polymorphism -LRB- rs2854744 -RRB- of the IGFBP-3 gene on erectile_dysfunction risk and serum levels of IGF-I and IGFBP-3 .
23473966	0	IGF-I	74,79	IGFBP-3	108,115	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Serum but not cerebrospinal fluid levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- are increased in Alzheimer 's _ disease .
25817945	0	IGF-I	17,22	IGFBP-3	52,59	IGF-I	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|dep|Association Association|nmod|changes changes|nmod|proteolysis proteolysis|compound|END_ENTITY	Free dissociable IGF-I : Association with changes in IGFBP-3 proteolysis and insulin sensitivity after surgery .
7505289	0	IGF-I	176,181	IGFBP-3	193,200	IGF-I	IGFBP-3	3479	3486	Gene	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	The composition and distribution of insulin-like growth factors -LRB- IGFs -RRB- and IGF-binding proteins -LRB- IGFBPs -RRB- in the serum of growth_hormone_receptor-deficient patients : effects of IGF-I therapy on IGFBP-3 .
7523204	0	IGF-I	59,64	IGFBP-3	14,21	IGF-I	IGFBP-3	3479	3486	Gene	Gene	actions|nmod|START_ENTITY potentiates|dobj|actions potentiates|nsubj|END_ENTITY	IGF-I-induced IGFBP-3 potentiates the mitogenic actions of IGF-I in mammary epithelial MD-IGF-I cells .
7524925	0	IGF-I	49,54	IGFBP-3	83,90	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7543116	0	IGF-I	140,145	IGFBP-3	68,75	IGF-I	IGFBP-3	3479	3486	Gene	Gene	index|amod|START_ENTITY relation|nmod|index levels|dep|relation levels|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
7546777	0	IGF-I	30,35	IGFBP-3	47,54	IGF-I	IGFBP-3	3479	3486	Gene	Gene	Insulin-like_growth_factor-I|appos|START_ENTITY regulates|nsubj|Insulin-like_growth_factor-I regulates|xcomp|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- regulates IGFBP-3 and IGFBP-4 by multiple mechanisms in A549 human adenocarcinoma cells .
7696822	0	IGF-I	111,116	IGFBP-3	68,75	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor_binding_protein_3|appos|START_ENTITY insulin-like_growth_factor_binding_protein_3|appos|END_ENTITY	Circulating levels of insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- and insulin-like_growth_factor_I -LRB- IGF-I -RRB- in perimenopausal women .
8612547	0	IGF-I	199,204	IGFBP-3	67,74	IGF-I	IGFBP-3	24482(Tax:10116)	24484(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY promotes|dobj|release promotes|nsubj|Proteolysis Proteolysis|nmod|_ _|dep|END_ENTITY	Proteolysis of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in 150-kilodalton IGFBP complexes by a cation-dependent protease activity in adult rat serum promotes the release of bound IGF-I .
8674839	0	IGF-I	84,89	IGFBP-3	141,148	IGF-I	IGFBP-3	24482(Tax:10116)	24484(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Estradiol and triiodothyronine increase production of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- by GH4C1 rat pituitary_tumor cells .
8717444	0	IGF-I	61,66	IGFBP-3	26,33	IGF-I	IGFBP-3	3479	3486	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|synthesis synthesis|amod|END_ENTITY	Regulation of endothelial IGFBP-3 synthesis and secretion by IGF-I and TGF-beta .
9160813	0	IGF-I	51,56	IGFBP-3	85,92	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Comparative study of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- level and IGF-I/IGFBP -3 ratio measurements and their relationship with an index of clinical activity in the management of patients with acromegaly .
9387030	0	IGF-I	45,50	IGFBP-3	90,97	IGF-I	IGFBP-3	3479	3486	Gene	Gene	levels|appos|START_ENTITY _|nsubj|levels _|ccomp|elevated elevated|nsubj|and_their_binding_protein and_their_binding_protein|appos|END_ENTITY	Serum levels of insulin-like growth factors -LRB- IGF-I and IGF-II -RRB- _ and_their_binding_protein -LRB- IGFBP-3 -RRB- are not elevated in pancreatic_cancer .
9497875	0	IGF-I	116,121	IGFBP-3	71,78	IGF-I	IGFBP-3	3479	3486	Gene	Gene	infusion|appos|START_ENTITY infusion|nmod|subunit subunit|dep|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9497875	0	IGF-I	41,46	IGFBP-3	71,78	IGF-I	IGFBP-3	3479	3486	Gene	Gene	infusion|nmod|START_ENTITY infusion|nmod|subunit subunit|dep|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9829225	0	IGF-I	170,175	IGFBP-3	204,211	IGF-I	IGFBP-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Treatment of peripubertal children after renal transplantation -LRB- RTX -RRB- with recombinant human growth hormone : auxological data and effects on insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- during 24 months .
17116363	0	IGF-I	112,117	IGFR-1	140,146	IGF-I	IGFR-1	104978413	281848(Tax:9913)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- system during follicle development in the bovine ovary : relationship among IGF-I , type 1 IGF receptor -LRB- IGFR-1 -RRB- and pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- .
17116363	0	IGF-I	30,35	IGFR-1	140,146	IGF-I	IGFR-1	104978413	281848(Tax:9913)	Gene	Gene	system|appos|START_ENTITY system|dep|relationship relationship|nmod|receptor receptor|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- system during follicle development in the bovine ovary : relationship among IGF-I , type 1 IGF receptor -LRB- IGFR-1 -RRB- and pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- .
10971450	0	IGF-I	47,52	IGF_binding_protein-3	55,76	IGF-I	IGF binding protein-3	3479	3486	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Monitoring serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and leptin during growth hormone treatment for disordered growth .
9614361	0	IGF-I	33,38	IGF_binding_protein-3	152,173	IGF-I	IGF binding protein-3	3479	3486	Gene	Gene	administration|compound|START_ENTITY effects|nmod|administration effects|nmod|END_ENTITY	The effects of recombinant human IGF-I administration on concentrations of acid_labile_subunit , IGF_binding_protein-3 , IGF-I , IGF-II and proteolysis of IGF_binding_protein-3 in adolescents with insulin-dependent_diabetes_mellitus .
14575864	0	IGF-I	0,5	IL-8	17,21	IGF-I	IL-8	3479	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase .
10049759	0	IGF-I	0,5	IRS-1	16,21	IGF-I	IRS-1	3479	3667	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IGF-I regulates IRS-1 expression in 3T3-L1 adipocytes .
12101028	0	IGF-I	106,111	IRS-1	54,59	IGF-I	IRS-1	16000(Tax:10090)	16367(Tax:10090)	Gene	Gene	stimulation|appos|START_ENTITY block|dobj|stimulation fails|xcomp|block fails|nsubj|expression expression|nmod|insulin_receptor_substrate-1 insulin_receptor_substrate-1|appos|END_ENTITY	Deficient expression of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- fails to block insulin-like_growth_factor-I -LRB- IGF-I -RRB- stimulation of brain growth and myelination .
10868937	0	IGF-I	21,26	Ins-1	73,78	IGF-I	Ins-1	24482(Tax:10116)	24505(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Inhibitory effect of IGF-I on type 2 nitric_oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis : involvement of phosphatidylinositol 3-kinase .
26680853	0	IGF-I	45,50	Insulin-like_Growth_Factor-I	15,43	IGF-I	Insulin-like Growth Factor-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	The Effects of Insulin-like_Growth_Factor-I -LRB- IGF-I -RRB- in Mouse Lung_Cancer Cells .
8722689	0	IGF-I	28,33	Insulin-like_growth_factor	0,26	IGF-I	Insulin-like growth factor	3479	3479	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Insulin-like_growth_factor -LRB- IGF-I -RRB- mRNA and IGF-I_receptor in trout testis and in isolated spermatogenic and Sertoli cells .
17116363	0	IGF-I	30,35	Insulin-like_growth_factor-I	0,28	IGF-I	Insulin-like growth factor-I	104978413	104978413	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- system during follicle development in the bovine ovary : relationship among IGF-I , type 1 IGF receptor -LRB- IGFR-1 -RRB- and pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- .
2118859	0	IGF-I	30,35	Insulin-like_growth_factor_I	0,28	IGF-I	Insulin-like growth factor I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels in follicular fluid from human preovulatory follicles : correlation with serum IGF-I levels .
11081190	0	IGF-I	13,18	Leptin	0,6	IGF-I	Leptin	3479	3952	Gene	Gene	generation|amod|START_ENTITY END_ENTITY|nmod|generation	Leptin after IGF-I generation test in a patient with hypopituitarism and myotonic_dystrophy_disease .
15351513	0	IGF-I	66,71	Mcl-1	14,19	IGF-I	Mcl-1	16000(Tax:10090)	17210(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of Mcl-1 in cerebellar granule neurons is regulated by IGF-I in a developmentally specific fashion .
25286675	0	IGF-I	114,119	PAPP-A	15,21	IGF-I	PAPP-A	3479	5069	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of PAPP-A , IGF-I and their effects on the cytological functions of siRNA lentiviral vector of hCASMCs IGF-I after inflammatory factor -RSB- .
22363152	0	IGF-I	10,15	PDGF-A	101,107	IGF-I	PDGF-A	3479	5154	Gene	Gene	Effect|nmod|START_ENTITY Related|nsubj|Effect Related|nmod|Effect Effect|nmod|END_ENTITY	Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B .
22363152	0	IGF-I	74,79	PDGF-A	101,107	IGF-I	PDGF-A	3479	5154	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B .
19658040	0	IGF-I	57,62	PlGF	45,49	IGF-I	PlGF	3479	5228	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Mutation analysis of the growth factor genes PlGF , Flt1 , IGF-I , and IGF-IR in intrauterine_growth_restriction with abnormal placental blood flow .
26720454	0	IGF-I	55,60	Protein_Tyrosine_Phosphatase_1B	14,45	IGF-I	Protein Tyrosine Phosphatase 1B	16000(Tax:10090)	19246(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Inhibition of Protein_Tyrosine_Phosphatase_1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced_Gliosis in the Retina .
21961005	0	IGF-I	94,99	Rac1	0,4	IGF-I	Rac1	3479	5879	Gene	Gene	Cells|nmod|START_ENTITY Cells|nsubj|END_ENTITY	Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast_Cancer Cells in Response to IGF-I .
12658115	0	IGF-I	0,5	S6K1_and_4E-BP1	33,48	IGF-I	S6K1 and 4E-BP1	24482(Tax:10116)	83840;116636	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	IGF-I induced phosphorylation of S6K1_and_4E-BP1 in heart is impaired by acute_alcohol_intoxication .
20553076	0	IGF-I	53,58	TGF-b1	77,83	IGF-I	TGF-b1	3479	7040	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Associations of food and nutrient intakes with serum IGF-I , IGF-II , IGFBP-3 , TGF-b1 , total SOD activity and sFas levels among middle-aged Japanese : the Japan Collaborative Cohort study .
12837295	0	IGF-I	25,30	TGF-beta_1	0,10	IGF-I	TGF-beta 1	24482(Tax:10116)	59086(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	TGF-beta_1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells .
22776750	0	IGF-I	35,40	VEGF	59,63	IGF-I	VEGF	3479	7422	Gene	Gene	AMH|compound|START_ENTITY AMH|appos|END_ENTITY	Follicular fluid concentrations of IGF-I , IGF-II , IGFBP-3 , VEGF , AMH , and inhibin-B in women undergoing controlled ovarian_hyperstimulation using GnRH agonist or GnRH antagonist .
9582085	0	IGF-I	105,110	VEGF	152,156	IGF-I	VEGF	24482(Tax:10116)	83785(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Sex hormone-induced prostatic_carcinogenesis in the noble rat : the role of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the development of prostate_cancer .
11275953	0	IGF-I	16,21	alkaline_phosphatase	54,74	IGF-I	alkaline phosphatase	3479	250	Gene	Gene	decrease|nmod|START_ENTITY END_ENTITY|nsubj|decrease	The decrease of IGF-I , IGF-binding_protein-3 and bone alkaline_phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac_disease .
21551900	0	IGF-I	64,69	bFGF	107,111	IGF-I	bFGF	24482(Tax:10116)	54250(Tax:10116)	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Nerve regeneration is improved by insulin-like_growth_factor_I -LRB- IGF-I -RRB- and basic_flbroblast_growth_factor -LRB- bFGF -RRB- .
8745211	0	IGF-I	77,82	bFGF	39,43	IGF-I	bFGF	24482(Tax:10116)	54250(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Influence of fibroblast growth factor -LRB- bFGF -RRB- and insulin-like growth factor -LRB- IGF-I -RRB- on cytoskeletal and contractile structures and on atrial_natriuretic_factor -LRB- ANF -RRB- expression in adult rat ventricular cardiomyocytes in culture .
3355549	0	IGF-I	0,5	c-fos	16,21	IGF-I	c-fos	24482(Tax:10116)	314322(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	IGF-I increases c-fos expression in FRTL5 rat thyroid cells by activating the c-fos promoter .
12135605	0	IGF-I	0,5	caveolin_1	14,24	IGF-I	caveolin 1	3479	857	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	IGF-I induces caveolin_1 tyrosine phosphorylation and translocation in the lipid rafts .
18855015	0	IGF-I	0,5	claudin-1	39,48	IGF-I	claudin-1	16000(Tax:10090)	12737(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway .
15033176	0	IGF-I	0,5	cyclin_D1	37,46	IGF-I	cyclin D1	3479	595	Gene	Gene	enhance|nsubj|START_ENTITY enhance|dobj|association association|amod|END_ENTITY	IGF-I and FGF-2 coordinately enhance cyclin_D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells .
15580291	0	IGF-I	48,53	cyclin_D1	14,23	IGF-I	cyclin D1	3479	595	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclin_D1 expression by autocrine IGF-I in human BON_neuroendocrine_tumour cells .
17508424	0	IGF-I	74,79	cyclin_D1	25,34	IGF-I	cyclin D1	3479	595	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Synergistic induction of cyclin_D1 in oligodendrocyte progenitor cells by IGF-I and FGF-2 requires differential stimulation of multiple signaling pathways .
8717450	0	IGF-I	78,83	epidermal_growth_factor	14,37	IGF-I	epidermal growth factor	24482(Tax:10116)	25313(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels END_ENTITY|acl|circulating	The effect of epidermal_growth_factor on circulating levels of free and total IGF-I and IGF-binding proteins in adult rats .
11796505	0	IGF-I	102,107	extracellular_signal-regulated_kinase_1	41,80	IGF-I	extracellular signal-regulated kinase 1	3479	5594	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Early stimulation and late inhibition of extracellular_signal-regulated_kinase_1 / 2 phosphorylation by IGF-I : a potential mechanism mediating the switch in IGF-I action on skeletal muscle cell differentiation .
10102080	0	IGF-I	55,60	growth_hormone	119,133	IGF-I	growth hormone	3479	2688	Gene	Gene	I|appos|START_ENTITY increments|nmod|I predict|nsubj|increments predict|nmod|therapy therapy|amod|END_ENTITY	Short-term increments of insulin-like growth factor I -LRB- IGF-I -RRB- and IGF-binding_protein-3 predict the growth response to growth_hormone -LRB- GH -RRB- therapy in GH-sensitive children .
10208950	0	IGF-I	11,16	growth_hormone	41,55	IGF-I	growth hormone	3479	2688	Gene	Gene	Failure|nmod|START_ENTITY Failure|acl|diagnose diagnose|dobj|insufficiency insufficiency|amod|END_ENTITY	Failure of IGF-I and IGFBP-3 to diagnose growth_hormone insufficiency .
10435854	0	IGF-I	7,12	growth_hormone	35,49	IGF-I	growth hormone	3479	2688	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|deficiency deficiency|amod|END_ENTITY	Plasma IGF-I is a useful marker of growth_hormone deficiency in adults .
10469014	0	IGF-I	6,11	growth_hormone	65,79	IGF-I	growth hormone	3479	2688	Gene	Gene	predict|nsubj|START_ENTITY predict|dobj|deficiency deficiency|amod|END_ENTITY	Serum IGF-I and IGFBP-3 concentrations do not accurately predict growth_hormone deficiency in children with brain_tumours .
10502457	0	IGF-I	91,96	growth_hormone	28,42	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY induction|nmod|mRNA END_ENTITY|dep|induction	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
10668288	0	IGF-I	62,67	growth_hormone	128,142	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY measurement|nmod|insulin-like_growth_factor Usefulness|nmod|measurement Usefulness|nmod|diagnosis diagnosis|nmod|_ _|amod|END_ENTITY	-LSB- Usefulness of the measurement of insulin-like_growth_factor -LRB- IGF-I -RRB- and IGF-1_binding_protein-3 -LRB- IGFBP-3 -RRB- for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in children -RSB- .
10828837	0	IGF-I	0,5	growth_hormone	97,111	IGF-I	growth hormone	24482(Tax:10116)	2688	Gene	Gene	proteins|compound|START_ENTITY given|nsubj|proteins given|dobj|END_ENTITY	IGF-I and IGF-I-binding proteins in rats with adjuvant-induced arthritis given recombinant human growth_hormone .
10844596	0	IGF-I	51,56	growth_hormone	36,50	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	axis|amod|START_ENTITY Effect|dep|axis Effect|nmod|metabolic_acidosis metabolic_acidosis|nmod|END_ENTITY	Effect of metabolic_acidosis on the growth_hormone / IGF-I endocrine axis in skeletal growth centers .
10863894	0	IGF-I	26,31	growth_hormone	48,62	IGF-I	growth hormone	3479	2688	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|deficiency deficiency|amod|END_ENTITY	Measurement of serum free IGF-I in diagnosis of growth_hormone deficiency .
10890180	0	IGF-I	79,84	growth_hormone	13,27	IGF-I	growth hormone	3479	14599(Tax:10090)	Gene	Gene	factor-I|appos|START_ENTITY expression|nsubj|factor-I stimulates|xcomp|expression stimulates|nsubj|END_ENTITY	20 kDa human growth_hormone -LRB- 20K hGH -RRB- stimulates insulin-like growth factor-I -LRB- IGF-I -RRB- gene expression at lower concentrations than 22K hGH in hGH_receptor-expressing Ba/F3 cells .
10985758	0	IGF-I	77,82	growth_hormone	29,43	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY decrease|nmod|expression prevent|dobj|decrease prevent|nsubj|administration administration|nmod|END_ENTITY	Continuous administration of growth_hormone does not prevent the decrease of IGF-I gene expression in zinc-deprived rats despite normalization of liver GH binding .
11181253	0	IGF-I	20,25	growth_hormone	70,84	IGF-I	growth hormone	3479	2688	Gene	Gene	sensitivity|nmod|START_ENTITY GH|nsubj|sensitivity GH|nmod|diagnosis diagnosis|nmod|insufficiency insufficiency|amod|END_ENTITY	-LSB- Low sensitivity of IGF-I , IGFBP-3 and urinary GH in the diagnosis of growth_hormone insufficiency in slowly-growing short-statured boys .
11466586	0	IGF-I	10,15	growth_hormone	34,48	IGF-I	growth hormone	3479	2688	Gene	Gene	administration|amod|START_ENTITY Effect|nmod|administration Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of IGF-I administration on growth_hormone secretion in obese subjects .
11847474	0	IGF-I	26,31	growth_hormone	47,61	IGF-I	growth hormone	3479	2688	Gene	Gene	value|nmod|START_ENTITY value|nmod|disorders disorders|amod|END_ENTITY	Diagnostic value of serum IGF-I and IGFBP-3 in growth_hormone disorders in adults .
12201823	0	IGF-I	121,126	growth_hormone	23,37	IGF-I	growth hormone	3479	2688	Gene	Gene	generation|amod|START_ENTITY capacity|nmod|generation markers|dep|capacity markers|nmod|sensitivity sensitivity|amod|END_ENTITY	Biochemical markers of growth_hormone -LRB- GH -RRB- sensitivity in children with idiopathic_short_stature : individual capacity of IGF-I generation after high-dose GH treatment determines the growth response to GH .
12409314	0	IGF-I	126,131	growth_hormone	106,120	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	excess|amod|START_ENTITY separates|dep|excess separates|dobj|effects effects|nmod|END_ENTITY	Insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- separates hypertrophic and hyperplastic effects of growth_hormone -LRB- GH -RRB- / IGF-I excess on adrenocortical cells in vivo .
12478375	0	IGF-I	174,179	growth_hormone	159,173	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|size size|dep|not not|nmod|absence absence|nmod|END_ENTITY	Insulin-like_growth_factor-binding_protein-2 -LRB- IGFBP-2 -RRB- overexpression negatively regulates bone size and mass , but not density , in the absence and presence of growth_hormone / IGF-I excess in transgenic_mice .
12763169	0	IGF-I	71,76	growth_hormone	22,36	IGF-I	growth hormone	3479	2688	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Synergistic action of growth_hormone and insulin-like_growth_factor_I -LRB- IGF-I -RRB- on proliferation and estradiol secretion in porcine granulosa and theca cells cultured alone or in coculture .
12906369	0	IGF-I	93,98	growth_hormone	42,56	IGF-I	growth hormone	3479	2688	Gene	Gene	concentrations|amod|START_ENTITY circulating|dobj|concentrations restore|xcomp|circulating restore|nsubj|injections injections|nmod|END_ENTITY	Three weekly injections -LRB- TWI -RRB- of low-dose growth_hormone -LRB- GH -RRB- restore low normal circulating IGF-I concentrations and reverse cardiac_abnormalities associated with adult_onset GH_deficiency -LRB- GHD -RRB- .
12944101	0	IGF-I	124,129	growth_hormone	48,62	IGF-I	growth hormone	3479	2688	Gene	Gene	impact|nmod|START_ENTITY explanation|nmod|impact hepatocytes|dep|explanation signaling|nmod|hepatocytes END_ENTITY|xcomp|signaling	Estrogen agonists/antagonists may down-regulate growth_hormone signaling in hepatocytes -- an explanation for their impact on IGF-I , IGFBP-1 , and lipoprotein -LRB- a -RRB- .
1306846	0	IGF-I	36,41	growth_hormone	10,24	IGF-I	growth hormone	3479	2688	Gene	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Effect of growth_hormone therapy on IGF-I , bone_GLA-protein and bone mineral content in short children with and without chronic_renal_failure .
14565994	0	IGF-I	74,79	growth_hormone	32,46	IGF-I	growth hormone	3479	2688	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	The effect of recombinant human growth_hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men .
14714750	0	IGF-I	49,54	growth_hormone	126,140	IGF-I	growth hormone	3479	2688	Gene	Gene	gene|amod|START_ENTITY Analysis|nmod|gene Analysis|nmod|growth_disorders growth_disorders|acl|presenting presenting|nmod|level level|nmod|END_ENTITY	Analysis of coding and promoter sequences of the IGF-I gene in children with growth_disorders presenting with normal level of growth_hormone .
14960017	0	IGF-I	77,82	growth_hormone	31,45	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY levels|appos|insulin-like_growth_factor-I levels|nmod|END_ENTITY	Basal and stimulated levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-I binding and IGF-binding proteins in beta-thalassemia major .
14960017	0	IGF-I	85,90	growth_hormone	31,45	IGF-I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|END_ENTITY	Basal and stimulated levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-I binding and IGF-binding proteins in beta-thalassemia major .
14997011	0	IGF-I	50,55	growth_hormone	130,144	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	Modulation|appos|START_ENTITY binding|nsubj|Modulation binding|nmod|exogenous exogenous|amod|END_ENTITY	Modulation of brain insulin-like_growth_factor_I -LRB- IGF-I -RRB- binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth_hormone and IGF-I in juvenile rats .
15125887	0	IGF-I	8,13	growth_hormone	30,44	IGF-I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|myocardial_infarction myocardial_infarction|amod|END_ENTITY	Cardiac IGF-I manipulation by growth_hormone following myocardial_infarction .
15270408	0	IGF-I	82,87	growth_hormone	21,35	IGF-I	growth hormone	3479	2688	Gene	Gene	components|appos|START_ENTITY GH|dep|components Alterations|dep|GH Alterations|nmod|END_ENTITY	Alterations in serum growth_hormone -LRB- GH -RRB- / GH dependent ternary complex components -LRB- IGF-I , IGFBP-3 , ALS , IGF-I/IGFBP -3 molar ratio -RRB- and the influence of these alterations on growth pattern in female rhythmic gymnasts .
15583470	0	IGF-I	30,35	growth_hormone	88,102	IGF-I	growth hormone	3479	2688	Gene	Gene	Insulin-like_growth_factor_I|dep|START_ENTITY Insulin-like_growth_factor_I|nmod|markers markers|nmod|deficiency deficiency|amod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein_3 as diagnostic markers of growth_hormone deficiency in infancy .
15684342	0	IGF-I	95,100	growth_hormone	42,56	IGF-I	growth hormone	100327329(Tax:9031)	378781(Tax:9031)	Gene	Gene	level|appos|START_ENTITY insulin-like_growth_factor-I|dobj|level modulate|advcl|insulin-like_growth_factor-I modulate|dobj|effect effect|nmod|END_ENTITY	Metabolic hormones modulate the effect of growth_hormone -LRB- GH -RRB- on insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA level in primary culture of salmon hepatocytes .
16039893	0	IGF-I	30,35	growth_hormone	53,67	IGF-I	growth hormone	3479	2688	Gene	Gene	measurements|appos|START_ENTITY Insulin-like_growth_factor_I|dobj|measurements Insulin-like_growth_factor_I|nmod|therapy therapy|amod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- measurements in growth_hormone -LRB- GH -RRB- therapy of idiopathic_short_stature -LRB- ISS -RRB- .
16294267	0	IGF-I	109,114	growth_hormone	15,29	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY regulator|nmod|synthesis regulator|nsubj|Growth Growth|nmod|estradiol estradiol|amod|END_ENTITY	Growth without growth_hormone receptor : estradiol is a major growth_hormone-independent regulator of hepatic IGF-I synthesis .
1658632	0	IGF-I	30,35	growth_hormone	52,66	IGF-I	growth hormone	3479	2688	Gene	Gene	attenuation|appos|START_ENTITY attenuation|nmod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- attenuation of growth_hormone is enhanced by overexpression of pituitary IGF-I_receptors .
16862465	0	IGF-I	59,64	growth_hormone	170,184	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY changes|nmod|insulin-like_growth_factor_I changes|nmod|patients patients|nmod|_ _|amod|END_ENTITY	Pregnancy-induced changes in insulin-like_growth_factor_I -LRB- IGF-I -RRB- , insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- , and acid-labile_subunit -LRB- ALS -RRB- in patients with growth_hormone _ -LRB- GH -RRB- _ deficiency and excess .
16908209	0	IGF-I	23,28	growth_hormone	112,126	IGF-I	growth hormone	3479	2688	Gene	Gene	IGFBP-3|compound|START_ENTITY correlation|nmod|IGFBP-3 test|nsubj|correlation test|nmod|months months|nmod|therapy therapy|compound|END_ENTITY	The correlation of the IGF-I , IGFBP-3 , and ALS generation test to height velocity after 6 months of recombinant growth_hormone therapy in girls with Turner_syndrome .
1710624	0	IGF-I	101,106	growth_hormone	31,45	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY levels|nmod|insulin-like_growth_factor-I circulating|dobj|levels END_ENTITY|acl|circulating	Short and long term effects of growth_hormone on circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-1 , and insulin : a placebo-controlled study .
1721016	0	IGF-I	7,12	growth_hormone	62,76	IGF-I	growth hormone	443318(Tax:9940)	443329(Tax:9940)	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|effect effect|nmod|treatment treatment|compound|END_ENTITY	Plasma IGF-I binding proteins in sheep : effect of recombinant growth_hormone treatment and nutritional status .
18167466	0	IGF-I	84,89	growth_hormone	68,82	IGF-I	growth hormone	3479	2688	Gene	Gene	Indications|appos|START_ENTITY Indications|nmod|determination determination|nmod|END_ENTITY	Indications , limitations and pitfalls in the determination of human growth_hormone , IGF-I and their binding proteins .
18647804	0	IGF-I	49,54	growth_hormone	108,122	IGF-I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY preservation|nmod|levels mediate|dobj|preservation mediate|nmod|secretion secretion|compound|END_ENTITY	Androgens may mediate a relative preservation of IGF-I levels in overweight and obese women despite reduced growth_hormone secretion .
1885393	0	IGF-I	95,100	growth_hormone	70,84	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	concentrations|compound|START_ENTITY enhances|nmod|concentrations enhances|dobj|effect effect|nmod|END_ENTITY	Cortisone arrests growth but enhances the inductive effect of porcine growth_hormone on plasma IGF-I concentrations in female rats .
19055455	0	IGF-I	58,63	growth_hormone	129,143	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY assays|nsubj|insulin-like_growth_factor_I assays|nmod|IGF-I IGF-I|nmod|END_ENTITY	Five commercially available insulin-like_growth_factor_I -LRB- IGF-I -RRB- assays in comparison to the former Nichols Advantage IGF-I in a growth_hormone treated population .
19083250	0	IGF-I	47,52	growth_hormone	22,36	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|acl|circulating circulating|dobj|END_ENTITY	Effect of circulating growth_hormone on muscle IGF-I protein concentration in female mice with growth_hormone receptor gene disruption .
19083250	0	IGF-I	47,52	growth_hormone	95,109	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	START_ENTITY|nmod|disruption disruption|amod|END_ENTITY	Effect of circulating growth_hormone on muscle IGF-I protein concentration in female mice with growth_hormone receptor gene disruption .
19570739	0	IGF-I	34,39	growth_hormone	76,90	IGF-I	growth hormone	3479	2688	Gene	Gene	generation|compound|START_ENTITY test|nsubj|generation test|nmod|indicator indicator|nmod|status status|amod|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- generation test as an indicator of growth_hormone status .
19571554	0	IGF-I	4,9	growth_hormone	22,36	IGF-I	growth hormone	3479	2688	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	The IGF-I response to growth_hormone is related to body mass index in short children with normal weight .
19916171	0	IGF-I	88,93	growth_hormone	10,24	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	mediators|amod|START_ENTITY homeostasis|nmod|mediators homeostasis|nsubj|Effect Effect|nmod|END_ENTITY	Effect of growth_hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3 .
2013221	0	IGF-I	47,52	growth_hormone	68,82	IGF-I	growth hormone	443318(Tax:9940)	443329(Tax:9940)	Gene	Gene	Effect|nmod|START_ENTITY Effect|acl|circulating circulating|dobj|concentrations concentrations|amod|END_ENTITY	Effect of intracerebroventricular injection of IGF-I on circulating growth_hormone concentrations in the sheep .
20190537	0	IGF-I	91,96	growth_hormone	141,155	IGF-I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY serum|dobj|levels serum|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Genetic polymorphisms in the locus control region and promoter of GH1 are related to serum IGF-I levels and height in patients with isolated growth_hormone deficiency and healthy controls .
2058394	0	IGF-I	55,60	growth_hormone	120,134	IGF-I	growth hormone	3479	2688	Gene	Gene	axis|amod|START_ENTITY /|dobj|axis /|nmod|END_ENTITY	Noonan 's _ syndrome : abnormalities of the growth_hormone / IGF-I axis and the response to treatment with human biosynthetic growth_hormone .
2058394	0	IGF-I	55,60	growth_hormone	40,54	IGF-I	growth hormone	3479	2688	Gene	Gene	axis|amod|START_ENTITY /|dobj|axis END_ENTITY|acl|/	Noonan 's _ syndrome : abnormalities of the growth_hormone / IGF-I axis and the response to treatment with human biosynthetic growth_hormone .
20733585	0	IGF-I	20,25	growth_hormone	4,18	IGF-I	growth hormone	3479	2688	Gene	Gene	axis|amod|START_ENTITY END_ENTITY|dep|axis	The growth_hormone -- IGF-I axis as a mediator for the association between FTO variants and body mass index : results of the Study of Health in Pomerania .
20890664	0	IGF-I	16,21	growth_hormone	49,63	IGF-I	growth hormone	3479	2688	Gene	Gene	inhibitor|amod|START_ENTITY Pasireotide|appos|inhibitor prevents|nsubj|Pasireotide prevents|dobj|hyperplasia hyperplasia|amod|END_ENTITY	Pasireotide , an IGF-I action inhibitor , prevents growth_hormone and estradiol-induced mammary hyperplasia .
21232100	0	IGF-I	3,8	growth_hormone	39,53	IGF-I	growth hormone	3479	2688	Gene	Gene	concentrations|amod|START_ENTITY reflect|nsubj|concentrations reflect|dobj|action action|amod|END_ENTITY	Do IGF-I concentrations better reflect growth_hormone -LRB- GH -RRB- action in children with short_stature than the results of GH stimulating tests ?
21367928	0	IGF-I	71,76	growth_hormone	139,153	IGF-I	growth hormone	3479	2688	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|bone_mineral_density bone_mineral_density|nmod|adults adults|nmod|deficiency deficiency|amod|END_ENTITY	Unreplaced sex steroid_deficiency , corticotropin_deficiency , and lower IGF-I are associated with lower bone_mineral_density in adults with growth_hormone deficiency : a KIMS database analysis .
21714461	0	IGF-I	4,9	growth_hormone	44,58	IGF-I	growth hormone	3479	2688	Gene	Gene	useful|nsubj|START_ENTITY useful|advcl|diagnosing diagnosing|dobj|deficiency deficiency|amod|END_ENTITY	Are IGF-I and IGF-BP3 useful for diagnosing growth_hormone deficiency in children of short_stature ?
21971154	0	IGF-I	6,11	growth_hormone	66,80	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|activity activity|compound|END_ENTITY	Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth_hormone activity in mice .
21975122	0	IGF-I	122,127	growth_hormone	84,98	IGF-I	growth hormone	3479	2688	Gene	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Transcriptional response of peripheral blood mononuclear cells to recombinant human growth_hormone in a routine four-days IGF-I generation test .
22924571	0	IGF-I	109,114	growth_hormone	22,36	IGF-I	growth hormone	3479	2688	Gene	Gene	children|nmod|START_ENTITY related|nsubjpass|children short_stature|ccomp|related short_stature|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of IGF-based growth_hormone -LRB- GH -RRB- dosing in nonGH-deficient -LRB- nonGHD -RRB- short_stature children with low IGF-I is not related to basal IGF-I levels .
22924571	0	IGF-I	139,144	growth_hormone	22,36	IGF-I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY basal|dobj|levels related|xcomp|basal short_stature|ccomp|related short_stature|nsubj|Efficacy Efficacy|nmod|END_ENTITY	Efficacy of IGF-based growth_hormone -LRB- GH -RRB- dosing in nonGH-deficient -LRB- nonGHD -RRB- short_stature children with low IGF-I is not related to basal IGF-I levels .
2360624	0	IGF-I	62,67	growth_hormone	10,24	IGF-I	growth hormone	3479	2688	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Placental growth_hormone as a potential regulator of maternal IGF-I during human pregnancy .
23685421	0	IGF-I	24,29	growth_hormone	126,140	IGF-I	growth hormone	3479	2688	Gene	Gene	ratio|compound|START_ENTITY increase|nmod|ratio predicts|nsubj|increase predicts|nmod|therapy therapy|amod|END_ENTITY	Significant increase of IGF-I concentration and of IGF-I/IGFBP -3 molar ratio in generation test predicts the good response to growth_hormone -LRB- GH -RRB- therapy in children with short_stature and normal results of GH stimulating tests .
25239917	0	IGF-I	20,25	growth_hormone	81,95	IGF-I	growth hormone	100008668(Tax:9986)	100356068(Tax:9986)	Gene	Gene	START_ENTITY|nmod|biomarker biomarker|acl|monitor monitor|dobj|bioactivity bioactivity|nmod|agonists agonists|compound|END_ENTITY	Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth_hormone agonists and antagonists in rabbits .
26774404	0	IGF-I	33,38	growth_hormone	112,126	IGF-I	growth hormone	3479	2688	Gene	Gene	skeletal|dobj|START_ENTITY skeletal|nmod|END_ENTITY	FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth_hormone .
3523759	0	IGF-I	66,71	growth_hormone	14,28	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	containing|dobj|START_ENTITY chondrocytes|acl|containing Regulation|nmod|chondrocytes Regulation|nmod|END_ENTITY	Regulation by growth_hormone of number of chondrocytes containing IGF-I in rat growth plate .
7508193	0	IGF-I	85,90	growth_hormone	10,24	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	exercise|nmod|START_ENTITY exercise|nsubj|Effect Effect|nmod|administration administration|amod|END_ENTITY	Effect of growth_hormone administration and treadmill exercise on serum and skeletal IGF-I in rats .
7510769	0	IGF-I	74,79	growth_hormone	11,25	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	growth_hormone|nmod|START_ENTITY synthesis|amod|growth_hormone rat|dobj|synthesis Effects|acl|rat Effects|nmod|END_ENTITY	Effects of growth_hormone and an antiserum to rat growth_hormone on serum IGF-I and muscle protein synthesis and accretion in the rat .
7513345	0	IGF-I	75,80	growth_hormone	10,24	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY steroidogenesis|appos|insulin-like_growth_factor-I END_ENTITY|nmod|steroidogenesis	Effect of growth_hormone on steroidogenesis , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-1 production and DNA synthesis in cultured human luteinized granulosa cells .
7524925	0	IGF-I	49,54	growth_hormone	124,138	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY Comparison|nmod|insulin-like_growth_factor-I measurement|nsubj|Comparison measurement|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7649526	0	IGF-I	28,33	growth_hormone	10,24	IGF-I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of growth_hormone on IGF-I levels in a patient with growth_hormone deficiency and Wilson_disease .
7649526	0	IGF-I	28,33	growth_hormone	59,73	IGF-I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY Effect|nmod|levels Effect|nmod|patient patient|nmod|deficiency deficiency|amod|END_ENTITY	Effect of growth_hormone on IGF-I levels in a patient with growth_hormone deficiency and Wilson_disease .
7978354	0	IGF-I	97,102	growth_hormone	23,37	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|protein protein|amod|END_ENTITY	Prenatal expression of growth_hormone receptor/binding protein and insulin-like growth factor-I -LRB- IGF-I -RRB- in the enamel organ .
8053796	0	IGF-I	37,42	growth_hormone	6,20	IGF-I	growth hormone	3479	2688	Gene	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Human growth_hormone effect on serum IGF-I and muscle function in poliomyelitis survivors .
8062113	0	IGF-I	56,61	growth_hormone	7,21	IGF-I	growth hormone	3479	2688	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Plasma growth_hormone and insulin-like growth factor-I -LRB- IGF-I -RRB- concentrations at the onset of lay in ad libitum and restricted broiler breeder fowl .
8462477	0	IGF-I	121,126	growth_hormone	161,175	IGF-I	growth hormone	443318(Tax:9940)	443329(Tax:9940)	Gene	Gene	START_ENTITY|nmod|status status|amod|END_ENTITY	Differential regulation of transcription initiation from insulin-like_growth_factor-I -LRB- IGF-I -RRB- leader exons and of tissue IGF-I expression in response to changed growth_hormone and nutritional status in sheep .
8531260	0	IGF-I	63,68	growth_hormone	12,26	IGF-I	growth hormone	3479	2688	Gene	Gene	factor-I|appos|START_ENTITY END_ENTITY|appos|factor-I	Circulating growth_hormone -LRB- GH -RRB- , insulin-like growth factor-I -LRB- IGF-I -RRB- and free thyroxine , GH response to clonidine provocation and CT scanning of the hypothalamic-pituitary area in children with sickle_cell_disease .
8567577	0	IGF-I	13,18	growth_hormone	46,60	IGF-I	growth hormone	3479	2688	Gene	Gene	Responses|nmod|START_ENTITY increases|nsubj|Responses increases|nmod|END_ENTITY	Responses of IGF-I to endogenous increases in growth_hormone after heavy-resistance exercise .
8632230	0	IGF-I	140,145	growth_hormone	75,89	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	concentrations|appos|START_ENTITY abolishes|dobj|concentrations abolishes|nmod|END_ENTITY	Moderate food restriction abolishes the pregnancy-associated rise in serum growth_hormone and decreases serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations without altering IGF-I mRNA expression in rats .
8632230	0	IGF-I	179,184	growth_hormone	75,89	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY altering|dobj|expression abolishes|advcl|altering abolishes|nmod|END_ENTITY	Moderate food restriction abolishes the pregnancy-associated rise in serum growth_hormone and decreases serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations without altering IGF-I mRNA expression in rats .
8674840	0	IGF-I	97,102	growth_hormone	28,42	IGF-I	growth hormone	100327329(Tax:9031)	378781(Tax:9031)	Gene	Gene	factor-I|appos|START_ENTITY administration|nmod|factor-I administration|amod|END_ENTITY	Effect of exogenous chicken growth_hormone -LRB- cGH -RRB- administration on insulin-like growth factor-I -LRB- IGF-I -RRB- gene expression in domestic fowl .
8690108	0	IGF-I	111,116	growth_hormone	132,146	IGF-I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|action action|amod|END_ENTITY	Insulin-like_growth_factor _ -LRB- IGF -RRB- - I and IGF-II stimulate progesterone production by human luteal cells : role of IGF-I as mediator of growth_hormone action .
8816035	0	IGF-I	107,112	growth_hormone	19,33	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY response|dep|insulin-like_growth_factor-I response|amod|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
8832140	0	IGF-I	108,113	growth_hormone	41,55	IGF-I	growth hormone	3479	2688	Gene	Gene	factor-I|appos|START_ENTITY END_ENTITY|nmod|factor-I	Effects of low dose of recombinant human growth_hormone on renal_excretion_of_insulin-like_growth factor-I -LRB- IGF-I -RRB- in humans : an inverse relation between serum and urinary IGF-I level .
8832140	0	IGF-I	172,177	growth_hormone	41,55	IGF-I	growth hormone	3479	2688	Gene	Gene	level|compound|START_ENTITY relation|nmod|level Effects|dep|relation Effects|nmod|dose dose|nmod|END_ENTITY	Effects of low dose of recombinant human growth_hormone on renal_excretion_of_insulin-like_growth factor-I -LRB- IGF-I -RRB- in humans : an inverse relation between serum and urinary IGF-I level .
8875138	0	IGF-I	81,86	growth_hormone	21,35	IGF-I	growth hormone	3479	2688	Gene	Gene	II|appos|START_ENTITY secretion|dep|II secretion|nmod|END_ENTITY	24-hour secretion of growth_hormone -LRB- GH -RRB- , insulin-like_growth_factors-I_and _ - II -LRB- IGF-I , - II -RRB- , prolactin -LRB- PRL -RRB- and thyrotropin -LRB- TSH -RRB- in young adults of normal and tall stature .
8989263	0	IGF-I	36,41	growth_hormone	146,160	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY IGF-binding_protein-1_and|nsubj|insulin-like_growth_factor_I IGF-binding_protein-1_and|nmod|therapy therapy|amod|END_ENTITY	Serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-1_and _ -3 , and the acid-labile_subunit as serum markers of body composition during growth_hormone -LRB- GH -RRB- therapy in adults with GH_deficiency .
9041052	0	IGF-I	107,112	growth_hormone	163,177	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY alkaline|nmod|insulin-like_growth_factor-I alkaline|nmod|adults adults|nmod|deficiency deficiency|amod|END_ENTITY	Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like_growth_factor-I -LRB- IGF-I -RRB- and during growth_hormone therapy in adults with growth_hormone deficiency .
9078817	0	IGF-I	30,35	growth_hormone	68,82	IGF-I	growth hormone	3479	2688	Gene	Gene	screening|appos|START_ENTITY screening|nmod|diagnosis diagnosis|nmod|_ _|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- screening for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency .
9225125	0	IGF-I	149,154	growth_hormone	26,40	IGF-I	growth hormone	100327329(Tax:9031)	378781(Tax:9031)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY concentrations|nmod|insulin-like_growth_factor-I circulating|dobj|concentrations exerts|advcl|circulating exerts|nsubj|administration administration|nmod|END_ENTITY	Chronic administration of growth_hormone -LRB- GH -RRB- to adult chickens exerts marked effects on circulating concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF binding proteins , hepatic GH regulated gene I , and hepatic GH_receptor mRNA .
9272424	0	IGF-I	51,56	growth_hormone	14,28	IGF-I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY correlate|nmod|levels correlate|nsubj|changes changes|nmod|levels levels|amod|END_ENTITY	Do changes in growth_hormone levels correlate with IGF-I levels in patients undergoing IVF-ET ?
9284715	0	IGF-I	96,101	growth_hormone	19,33	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY serum|dobj|insulin-like_growth_factor_I relates|xcomp|serum relates|nsubj|response response|nmod|treatment treatment|compound|END_ENTITY	Growth response to growth_hormone -LRB- GH -RRB- treatment relates to serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 in short children with various GH secretion capacities .
9555872	0	IGF-I	119,124	growth_hormone	74,88	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|amod|/ /|amod|END_ENTITY	Alcohol withdrawal-induced change in lipoprotein -LRB- a -RRB- : association with the growth_hormone / insulin-like_growth_factor-I -LRB- IGF-I -RRB- / IGF-binding_protein-1 -LRB- IGFBP-1 -RRB- axis .
9568461	0	IGF-I	15,20	growth_hormone	112,126	IGF-I	growth hormone	3479	2688	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|osteoblasts osteoblasts|nmod|END_ENTITY	The effects of IGF-I and IGF-II on proliferation and differentiation of human osteoblasts and interactions with growth_hormone .
9655774	0	IGF-I	0,5	growth_hormone	13,27	IGF-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	and/or|compound|START_ENTITY END_ENTITY|nsubj|and/or	IGF-I and/or growth_hormone preserve diaphragm fiber size with moderate malnutrition .
9661598	0	IGF-I	69,74	growth_hormone	151,165	IGF-I	growth hormone	3479	2688	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY assay|nmod|insulin-like_growth_factor_I assay|nmod|evaluation evaluation|nmod|status status|amod|END_ENTITY	Filter paper blood spot assay of human insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 and preliminary application in the evaluation of growth_hormone status .
9701698	0	IGF-I	104,109	growth_hormone	34,48	IGF-I	growth hormone	3479	2688	Gene	Gene	status|nmod|START_ENTITY status|nmod|children children|nmod|insensitivity_syndrome insensitivity_syndrome|amod|END_ENTITY	Metabolic status of children with growth_hormone insensitivity_syndrome and responses to treatment with IGF-I .
9849819	0	IGF-I	42,47	growth_hormone	24,38	IGF-I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY effects|nmod|levels effects|nmod|END_ENTITY	Dose-related effects of growth_hormone on IGF-I and IGF-binding_protein-3 levels in non-islet_cell_tumour_hypoglycaemia .
9859217	0	IGF-I	63,68	growth_hormone	18,32	IGF-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY affects|dobj|expression affects|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of growth_hormone affects alternatively spliced IGF-I mRNA expression in oMt1a-oGH transgenic_mice .
1821515	0	IGF-I	64,69	hPL	101,104	IGF-I	hPL	3479	3956	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Maternal plasma concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and human placental_lactogen -LRB- hPL -RRB- in twin pregnancies .
12952376	0	IGF-I	47,52	insulin-like_growth-factor-I	17,45	IGF-I	insulin-like growth-factor-I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Circulating free insulin-like_growth-factor-I -LRB- IGF-I -RRB- levels should also be measured to estimate the IGF-I bioactivity .
11172797	0	IGF-I	85,90	insulin-like_growth_factor	55,81	IGF-I	insulin-like growth factor	3479	3479	Gene	Gene	I|appos|START_ENTITY I|amod|END_ENTITY	Effects of two oral contraceptives on plasma levels of insulin-like_growth_factor I -LRB- IGF-I -RRB- and growth_hormone -LRB- hGH -RRB- .
12771153	0	IGF-I	66,71	insulin-like_growth_factor	38,64	IGF-I	insulin-like growth factor	3479	3479	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Two novel proteins that are linked to insulin-like_growth_factor -LRB- IGF-I -RRB- receptors by the Grb10 adapter and modulate IGF-I signaling .
10502457	0	IGF-I	91,96	insulin-like_growth_factor-I	61,89	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
10583308	0	IGF-I	34,39	insulin-like_growth_factor-I	4,32	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene in individuals born small for gestational age -LRB- SGA -RRB- .
10870582	0	IGF-I	74,79	insulin-like_growth_factor-I	44,72	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The beneficial effects of recombinant human insulin-like_growth_factor-I -LRB- IGF-I -RRB- on wound healing in severely wounded senescent mice .
11587544	0	IGF-I	63,68	insulin-like_growth_factor-I	33,61	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Local and systemic expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNAs in rat after bone_marrow_ablation .
11706070	0	IGF-I	44,49	insulin-like_growth_factor-I	14,42	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in aneurysmal_bone_cyst .
12800944	0	IGF-I	95,100	insulin-like_growth_factor-I	65,93	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene .
12828091	0	IGF-I	54,59	insulin-like_growth_factor-I	24,52	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in patients with liver_cirrhosis .
1377618	0	IGF-I	151,156	insulin-like_growth_factor-I	24,52	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of exogenous insulin-like_growth_factor-I -LRB- IGF-I -RRB- on the reproductive performance of female rats , and on serum concentrations of endogenous IGF-I and IGF-I binding proteins .
15141010	0	IGF-I	34,39	insulin-like_growth_factor-I	4,32	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptor kinase inhibitor NVP-ADW742 , in combination with STI571 , delineates a spectrum of dependence of small_cell_lung_cancer on IGF-I and stem_cell_factor signaling .
15464297	0	IGF-I	49,54	insulin-like_growth_factor-I	19,47	IGF-I	insulin-like growth factor-I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Trophic effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in the inner ear .
15745444	0	IGF-I	53,58	insulin-like_growth_factor-I	23,51	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Antioxidant effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in rats with advanced liver cirrhosis .
16219982	0	IGF-I	77,82	insulin-like_growth_factor-I	47,75	IGF-I	insulin-like growth factor-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Organ-specific and age-dependent expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA variants : IGF-IA and IB mRNAs in the mouse .
16298440	0	IGF-I	64,69	insulin-like_growth_factor-I	34,62	IGF-I	insulin-like growth factor-I	100305062(Tax:7998)	100305062(Tax:7998)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of the insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene in channel_catfish -LRB- Ictalurus_punctatus -RRB- .
16527837	0	IGF-I	56,61	insulin-like_growth_factor-I	26,54	IGF-I	insulin-like growth factor-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Genetic increase in serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-I exon 2 promoter .
1665320	0	IGF-I	106,111	insulin-like_growth_factor-I	76,104	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Effect of paraformaldehyde fixation on localization and characterization of insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors in the rat brain .
17108398	0	IGF-I	59,64	insulin-like_growth_factor-I	29,57	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic association study of insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene with curve severity and osteopenia in adolescent_idiopathic_scoliosis .
1715381	0	IGF-I	45,50	insulin-like_growth_factor-I	15,43	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I , a potent IGF analogue , on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells .
1715381	0	IGF-I	72,77	insulin-like_growth_factor-I	15,43	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I , a potent IGF analogue , on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells .
17668352	0	IGF-I	54,59	insulin-like_growth_factor-I	24,52	IGF-I	insulin-like growth factor-I	104978413	104978413	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Autocrine production of insulin-like_growth_factor-I -LRB- IGF-I -RRB- affects paracellular transport across epithelial cells in vitro .
18515085	0	IGF-I	133,138	insulin-like_growth_factor-I	103,131	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Adiponectin and resistin are associated with risk for myelodysplastic_syndrome , independently from the insulin-like_growth_factor-I -LRB- IGF-I -RRB- system .
18703307	0	IGF-I	52,57	insulin-like_growth_factor-I	22,50	IGF-I	insulin-like growth factor-I	104978413	104978413	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of endocrine insulin-like_growth_factor-I -LRB- IGF-I -RRB- in female bovine reproduction .
1883485	0	IGF-I	145,150	insulin-like_growth_factor-I	76,104	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression , purification and characterization of secreted recombinant human insulin-like_growth_factor-I -LRB- IGF-I -RRB- and the potent variant des -LRB- 1-3 -RRB- IGF-I in Chinese_hamster ovary cells .
1919400	0	IGF-I	62,67	insulin-like_growth_factor-I	32,60	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Reduced serum concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in protein-restricted growing rats are accompanied by reduced IGF-I mRNA levels in liver and skeletal muscle .
22166091	0	IGF-I	52,57	insulin-like_growth_factor-I	22,50	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- correlate with disease status in leprosy .
22626778	0	IGF-I	73,78	insulin-like_growth_factor-I	43,71	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of dietary energy on seminal plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- , serum IGF-I and testosterone levels , semen quality and fertility in adult rams .
22626778	0	IGF-I	87,92	insulin-like_growth_factor-I	43,71	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of dietary energy on seminal plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- , serum IGF-I and testosterone levels , semen quality and fertility in adult rams .
22673406	0	IGF-I	91,96	insulin-like_growth_factor-I	61,89	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Standardized centile curves and reference intervals of serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels in a normal Japanese population using the LMS method .
2549312	0	IGF-I	72,77	insulin-like_growth_factor-I	42,70	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Receptor autoradiographic localization of insulin-like_growth_factor-I -LRB- IGF-I -RRB- binding sites in human fetal and adult adrenal glands .
2558803	0	IGF-I	68,73	insulin-like_growth_factor-I	38,66	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Receptor autoradiographic analysis of insulin-like_growth_factor-I -LRB- IGF-I -RRB- binding sites in rat forebrain and pituitary gland .
2764927	0	IGF-I	58,63	insulin-like_growth_factor-I	28,56	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression and stability of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA splicing variants in the GH3 rat pituitary cell line .
2967888	0	IGF-I	59,64	insulin-like_growth_factor-I	29,57	IGF-I	insulin-like growth factor-I	104978413	104978413	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Bovine chromaffin cells have insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors : IGF-I enhances catecholamine secretion .
7510768	0	IGF-I	57,62	insulin-like_growth_factor-I	27,55	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Effect of fasting on serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels and IGF-I-binding activity in cockerels .
7689959	0	IGF-I	46,51	insulin-like_growth_factor-I	16,44	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Potentiation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- activity by an antibody : supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins .
7765981	0	IGF-I	76,81	insulin-like_growth_factor-I	46,74	IGF-I	insulin-like growth factor-I	100860838	100860838	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Dynamic aspects in the expression of the goat insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene : diversity in transcription and post-transcription .
7772848	0	IGF-I	82,87	insulin-like_growth_factor-I	52,80	IGF-I	insulin-like growth factor-I	100860838	100860838	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Tissue - and development-specific expression of goat insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNAs .
7904496	0	IGF-I	54,59	insulin-like_growth_factor-I	24,52	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	Concentrations|appos|START_ENTITY Concentrations|nmod|END_ENTITY	Concentrations of serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- in normal Chinese children and children with growth_hormone_deficiency .
7958109	0	IGF-I	69,74	insulin-like_growth_factor-I	39,67	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	-LSB- Maternal nutritional states and serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations in normal and abnormal pregnancy -RSB- .
8254297	0	IGF-I	50,55	insulin-like_growth_factor-I	20,48	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , hepatic growth hormone binding and IGF-I gene expression in the rat during pregnancy and lactation .
8280747	0	IGF-I	47,52	insulin-like_growth_factor-I	17,45	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Acute effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on bone protein synthesis in rats .
8425505	0	IGF-I	60,65	insulin-like_growth_factor-I	30,58	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Distinct promoters in the rat insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene are active in CHO cells .
8606645	0	IGF-I	163,168	insulin-like_growth_factor-I	133,161	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Two weeks of daily injections and continuous infusion of recombinant human growth_hormone -LRB- GH -RRB- in GH-deficient adults : I. Effects on insulin-like_growth_factor-I -LRB- IGF-I -RRB- , GH and IGF binding proteins , and glucose homeostasis .
8669848	0	IGF-I	151,156	insulin-like_growth_factor-I	121,149	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Somatuline -LRB- BIM_23014 -RRB- and tamoxifen treatment of postmenopausal_breast_cancer patients : clinical activity and effect on insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels .
8770611	0	IGF-I	98,103	insulin-like_growth_factor-I	68,96	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Influence of age and fetal hypophysectomy on porcine preadipocytes : insulin-like_growth_factor-I -LRB- IGF-I -RRB- response , receptor binding and IGF binding proteins secretion .
9027409	0	IGF-I	46,51	insulin-like_growth_factor-I	16,44	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Localisation|appos|START_ENTITY Localisation|nmod|END_ENTITY	Localisation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- immunoreactivity in the olivocerebellar system of developing and adult rats .
9030517	0	IGF-I	92,97	insulin-like_growth_factor-I	27,55	IGF-I	insulin-like growth factor-I	3479	3479	Gene	Gene	_|nmod|START_ENTITY _|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ receptor gene expression by IGF-I and basic fibroblastic growth factor .
9200562	0	IGF-I	68,73	insulin-like_growth_factor-I	38,66	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LRB- - -RRB- - Deprenyl treatment restores serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels in aged rats to young rat level .
9361347	0	IGF-I	61,66	insulin-like_growth_factor-I	31,59	IGF-I	insulin-like growth factor-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Cytokines block the effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on glucose uptake and lactate production in skeletal muscle but do not influence IGF-I-induced changes in protein turnover .
9568376	0	IGF-I	44,49	insulin-like_growth_factor-I	14,42	IGF-I	insulin-like growth factor-I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on protein turnover in the meat-type chicken -LRB- Gallus_domesticus -RRB- .
10199777	0	IGF-I	65,70	insulin-like_growth_factor_I	35,63	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Low serum levels of free and total insulin-like_growth_factor_I -LRB- IGF-I -RRB- in patients with anorexia_nervosa are not associated with increased IGF-binding_protein-3 proteolysis .
10323388	0	IGF-I	59,64	insulin-like_growth_factor_I	29,57	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human insulin-like_growth_factor_I -LRB- IGF-I -RRB- therapy on the growth hormone-IGF system of a patient with a partial IGF-I gene deletion .
11095464	0	IGF-I	46,51	insulin-like_growth_factor_I	16,44	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , IGF-binding_protein-3 , and prostate-specific_antigen as predictors of clinical prostate_cancer .
14557458	0	IGF-I	50,55	insulin-like_growth_factor_I	20,48	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between insulin-like_growth_factor_I -LRB- IGF-I -RRB- polymorphisms , circulating IGF-I , and pre - and postnatal growth in two European small for gestational age populations .
1478191	0	IGF-I	80,85	insulin-like_growth_factor_I	50,78	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Effects of age , sex and renal function on urinary insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels in adults .
15098919	0	IGF-I	44,49	insulin-like_growth_factor_I	14,42	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene and of genes for IGF-binding_proteins_1 , _ 2 , _ 3 , _ 4 -LRB- IGFBP-1-IGFBP-4 -RRB- in non-neoplastic human thyroid cells and in certain human thyroid_cancers .
1510832	0	IGF-I	41,46	insulin-like_growth_factor_I	11,39	IGF-I	insulin-like growth factor I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on Sertoli cell metabolism in the pubescent rat -RSB- .
15563671	0	IGF-I	48,53	insulin-like_growth_factor_I	18,46	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- in neonatal outcome .
15627646	0	IGF-I	49,54	insulin-like_growth_factor_I	19,47	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	accumulation|appos|START_ENTITY accumulation|nmod|END_ENTITY	An accumulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in human myometrium and uterine leiomyomas in various stages of tumour growth .
1661128	0	IGF-I	41,46	insulin-like_growth_factor_I	11,39	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on enzymatic activity in human adrenocortical cells .
1667296	0	IGF-I	69,74	insulin-like_growth_factor_I	39,67	IGF-I	insulin-like growth factor I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Climbing fiber deafferentation reduces insulin-like_growth_factor_I -LRB- IGF-I -RRB- content in cerebellum .
2028707	0	IGF-I	65,70	insulin-like_growth_factor_I	35,63	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Effects of aging and sex on plasma insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels in normal adults .
20979700	0	IGF-I	49,54	insulin-like_growth_factor_I	19,47	IGF-I	insulin-like growth factor I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in the mouse diaphragm during sepsis .
2156680	0	IGF-I	80,85	insulin-like_growth_factor_I	50,78	IGF-I	insulin-like growth factor I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	1,25-Dihydroxyvitamin _ D3 -LSB- 1,25 - -LRB- OH -RRB- 2D3 -RSB- increases insulin-like_growth_factor_I -LRB- IGF-I -RRB- receptors in clonal osteoblastic cells .
21882221	0	IGF-I	75,80	insulin-like_growth_factor_I	45,73	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Forkhead_box_A1 -LRB- FOXA1 -RRB- is a key mediator of insulin-like_growth_factor_I -LRB- IGF-I -RRB- activity .
21893211	0	IGF-I	72,77	insulin-like_growth_factor_I	42,70	IGF-I	insulin-like growth factor I	103384875	103384875	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning , expression analysis of insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene and IGF-I serum concentration in female and male Tongue_sole -LRB- Cynoglossus_semilaevis -RRB- .
2387267	0	IGF-I	34,39	insulin-like_growth_factor_I	4,32	IGF-I	insulin-like growth factor I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene is expressed in chick embryos during early organogenesis .
23886838	0	IGF-I	57,62	insulin-like_growth_factor_I	27,55	IGF-I	insulin-like growth factor I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Osteo-promoting effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in a mouse_model_of_type_1_diabetes .
2969239	0	IGF-I	50,55	insulin-like_growth_factor_I	20,48	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Characterization of insulin-like_growth_factor_I -LRB- IGF-I -RRB- receptors of human breast_cancer cells .
3108068	0	IGF-I	41,46	insulin-like_growth_factor_I	11,39	IGF-I	insulin-like growth factor I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
7515839	0	IGF-I	67,72	insulin-like_growth_factor_I	37,65	IGF-I	insulin-like growth factor I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization and expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in the mammary gland during rat gestation and lactation .
7577069	0	IGF-I	44,49	insulin-like_growth_factor_I	14,42	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in female_breast_cancer as related to established prognostic factors and long-term prognosis .
7951495	0	IGF-I	58,63	insulin-like_growth_factor_I	28,56	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Relationship between plasma insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels and body mass index -LRB- BMI -RRB- in adults .
7978067	0	IGF-I	44,49	insulin-like_growth_factor_I	14,42	IGF-I	insulin-like growth factor I	3479	3479	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in nevi and melanomas .
8793618	0	IGF-I	56,61	insulin-like_growth_factor_I	26,54	IGF-I	insulin-like growth factor I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Delayed expression of the insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene in the XY sex-reversed female mouse ovary .
8830986	0	IGF-I	44,49	insulin-like_growth_factor_I	14,42	IGF-I	insulin-like growth factor I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- mRNA variants in rat bone .
9389533	0	IGF-I	44,49	insulin-like_growth_factor_I	14,42	IGF-I	insulin-like growth factor I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene expression in brain of transgenic_mice expressing an IGF-I-luciferase fusion gene .
9794461	0	IGF-I	51,56	insulin-like_growth_factor_I	21,49	IGF-I	insulin-like growth factor I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Reduction|appos|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of hepatic insulin-like_growth_factor_I -LRB- IGF-I -RRB- messenger ribonucleic acid -LRB- mRNA -RRB- during fasting is associated with diminished splicing of IGF-I pre-mRNA and decreased stability of cytoplasmic IGF-I mRNA .
9284058	0	IGF-I	33,38	insulin_receptor	63,79	IGF-I	insulin receptor	24482(Tax:10116)	24954(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY END_ENTITY|nsubj|Distribution	Distribution and levels of -LSB- 125I -RSB- IGF-I , -LSB- 125I -RSB- IGF-II and -LSB- 125I -RSB- insulin_receptor binding sites in the hippocampus of aged memory-unimpaired and - impaired rats .
10590034	0	IGF-I	0,5	interferon-gamma	16,32	IGF-I	interferon-gamma	3479	3458	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	IGF-I increases interferon-gamma and IL-6 mRNA expression and protein production in neonatal mononuclear cells .
11916623	0	IGF-I	40,45	leptin	32,38	IGF-I	leptin	3479	3952	Gene	Gene	Associations|acl|START_ENTITY Associations|acl|END_ENTITY	Associations between body mass , leptin , IGF-I and circulating adrenal androgens in children with obesity and premature_adrenarche .
12054113	0	IGF-I	51,56	leptin	20,26	IGF-I	leptin	3479	3952	Gene	Gene	axis|nsubj|START_ENTITY Interaction|parataxis|axis Interaction|nmod|END_ENTITY	Interaction between leptin and growth_hormone -LRB- GH -RRB- / IGF-I axis .
12864793	0	IGF-I	40,45	leptin	69,75	IGF-I	leptin	3479	3952	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	The effect of pegvisomant-induced serum IGF-I normalization on serum leptin levels in patients with acromegaly .
14983407	0	IGF-I	37,42	leptin	51,57	IGF-I	leptin	3479	3952	Gene	Gene	system|amod|START_ENTITY D3|appos|system D3|appos|variables variables|compound|END_ENTITY	Relationship between 25 - -LRB- OH -RRB- _ D3 , the IGF-I system , leptin , anthropometric and body composition variables in a healthy , randomly selected population .
17020145	0	IGF-I	7,12	leptin	22,28	IGF-I	leptin	397491(Tax:9823)	396832(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Gh and IGF-I increase leptin receptor expression in prepubertal pig ovaries : the role of leptin in steroid secretion and cell apoptosis .
9822950	0	IGF-I	48,53	leptin	80,86	IGF-I	leptin	3479	3952	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY decreases|nsubj|insulin-like_growth_factor-I decreases|dobj|concentration concentration|compound|END_ENTITY	Recombinant human insulin-like_growth_factor-I -LRB- IGF-I -RRB- therapy decreases plasma leptin concentration in patients with chronic_renal_insufficiency .
9829217	0	IGF-I	69,74	leptin	6,12	IGF-I	leptin	3479	3952	Gene	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Serum leptin in obese patients with Laron_syndrome before and during IGF-I treatment .
12213884	0	IGF-I	0,5	osteoprotegerin	16,31	IGF-I	osteoprotegerin	3479	4982	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IGF-I regulates osteoprotegerin -LRB- OPG -RRB- and receptor_activator_of_nuclear_factor-kappaB ligand in vitro and OPG in vivo .
12844338	0	IGF-I	0,5	pro-opiomelanocortin	16,36	IGF-I	pro-opiomelanocortin	16000(Tax:10090)	18976(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IGF-I regulates pro-opiomelanocortin and GH gene expression in the mouse pituitary gland .
23702782	0	IGF-I	50,55	protein_tyrosine_phosphatase_1B	8,39	IGF-I	protein tyrosine phosphatase 1B	16000(Tax:10090)	19246(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Loss Loss|nmod|increases increases|amod|END_ENTITY	Loss of protein_tyrosine_phosphatase_1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal_defects in IRS2-deficient mice .
15585589	0	IGF-I	0,5	resistin	20,28	IGF-I	resistin	3479	56729	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	IGF-I downregulates resistin gene expression and protein secretion .
1945563	0	IGF-I	0,5	tropoelastin	17,29	IGF-I	tropoelastin	24482(Tax:10116)	25043(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	IGF-I stimulates tropoelastin synthesis in neonatal rat pulmonary fibroblasts .
9618150	0	IGF-I	41,46	uncoupling_protein_1	67,87	IGF-I	uncoupling protein 1	3479	7350	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling_protein_1 gene expression in brown adipocytes .
8175666	0	IGF-I-R	73,80	insulin-like_growth_factor_I_receptor	34,71	IGF-I-R	insulin-like growth factor I receptor	100768531	100768531	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional repression of the insulin-like_growth_factor_I_receptor -LRB- IGF-I-R -RRB- gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site .
17602833	0	IGF-II	101,107	Akt	126,129	IGF-II	Akt	3481	207	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The hedgehog pathway inhibitor cyclopamine increases levels of p27 , and decreases both expression of IGF-II and activation of Akt in PC-3_prostate_cancer cells .
18428028	0	IGF-II	10,16	Bcl-2	64,69	IGF-II	Bcl-2	3481	596	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Precursor IGF-II -LRB- proIGF-II -RRB- and mature IGF-II -LRB- mIGF-II -RRB- induce Bcl-2 And Bcl-X_L expression through different signaling pathways in breast_cancer cells .
11095464	0	IGF-II	54,60	IGF-I	46,51	IGF-II	IGF-I	3481	3479	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , IGF-binding_protein-3 , and prostate-specific_antigen as predictors of clinical prostate_cancer .
15302390	0	IGF-II	61,67	IGF-I	54,59	IGF-II	IGF-I	443325(Tax:9940)	443318(Tax:9940)	Gene	Gene	I|dep|START_ENTITY I|compound|END_ENTITY	Co-expression of messenger ribonucleic acids encoding IGF-I , IGF-II , type I and II IGF receptors and IGF-binding proteins -LRB- IGFBP-1 to -6 -RRB- during follicular development in the ovary of seasonally anoestrous ewes .
20553076	0	IGF-II	60,66	IGF-I	53,58	IGF-II	IGF-I	3481	3479	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Associations of food and nutrient intakes with serum IGF-I , IGF-II , IGFBP-3 , TGF-b1 , total SOD activity and sFas levels among middle-aged Japanese : the Japan Collaborative Cohort study .
22776750	0	IGF-II	42,48	IGF-I	35,40	IGF-II	IGF-I	3481	3479	Gene	Gene	AMH|appos|START_ENTITY AMH|compound|END_ENTITY	Follicular fluid concentrations of IGF-I , IGF-II , IGFBP-3 , VEGF , AMH , and inhibin-B in women undergoing controlled ovarian_hyperstimulation using GnRH agonist or GnRH antagonist .
7543116	0	IGF-II	147,153	IGF-I	140,145	IGF-II	IGF-I	3481	3479	Gene	Gene	index|dep|START_ENTITY index|amod|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
8624976	0	IGF-II	21,27	IGF-I	15,20	IGF-II	IGF-I	3481	3479	Gene	Gene	START_ENTITY|nsubj|insulin insulin|appos|END_ENTITY	Serum insulin , IGF-I , IGF-II and growth_hormone , and left ventricular mass in noninsulin-dependent mellitus .
11228264	0	IGF-II	0,6	IGFBP-1	32,39	IGF-II	IGFBP-1	3481	696994(Tax:9544)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	IGF-II and IGF binding protein -LRB- IGFBP-1 , IGFBP-3 -RRB- gene expression in fetal rhesus_monkey tissues during the second and third trimesters .
15302390	0	IGF-II	61,67	IGFBP-1	123,130	IGF-II	IGFBP-1	443325(Tax:9940)	443132(Tax:9940)	Gene	Gene	I|dep|START_ENTITY I|dep|END_ENTITY	Co-expression of messenger ribonucleic acids encoding IGF-I , IGF-II , type I and II IGF receptors and IGF-binding proteins -LRB- IGFBP-1 to -6 -RRB- during follicular development in the ovary of seasonally anoestrous ewes .
19199270	0	IGF-II	47,53	IGFBP-1	24,31	IGF-II	IGFBP-1	3481	3484	Gene	Gene	concentration|amod|START_ENTITY END_ENTITY|nmod|concentration	Association of elevated IGFBP-1 with increased IGF-II concentration in patients with carcinoma_of_the_liver .
7543116	0	IGF-II	147,153	IGFBP-1	155,162	IGF-II	IGFBP-1	3481	3484	Gene	Gene	index|dep|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
8784106	0	IGF-II	31,37	IGFBP-1	94,101	IGF-II	IGFBP-1	3481	3484	Gene	Gene	II|appos|START_ENTITY inhibits|nsubj|II inhibits|ccomp|factor factor|dobj|I I|appos|END_ENTITY	Insulin-like growth factor II -LRB- IGF-II -RRB- inhibits insulin-like growth factor binding protein I -LRB- IGFBP-1 -RRB- production in luteinized human granulosa cells with a potency similar to insulin-like growth factor I -LRB- IGF-I -RRB- and higher than insulin .
7543116	0	IGF-II	147,153	IGFBP-2	164,171	IGF-II	IGFBP-2	3481	3485	Gene	Gene	index|dep|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
7543116	0	IGF-II	147,153	IGFBP-3	68,75	IGF-II	IGFBP-3	3481	3486	Gene	Gene	index|dep|START_ENTITY relation|nmod|index levels|dep|relation levels|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
22249478	0	IGF-II	136,142	IL-1_b	81,87	IGF-II	IL-1 b	3481	3553	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
10229198	0	IGF-II	31,37	Insulin_receptor	0,16	IGF-II	Insulin receptor	3481	3643	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Insulin_receptor activation by IGF-II in breast_cancers : evidence for a new autocrine/paracrine mechanism .
10646861	0	IGF-II	111,117	PLAG1	0,5	IGF-II	PLAG1	3481	5324	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PLAG1 , the main translocation target in pleomorphic_adenoma of the salivary glands , is a positive regulator of IGF-II .
12804776	0	IGF-II	129,135	PTEN	110,114	IGF-II	PTEN	3481	5728	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	PTEN_modulates_insulin-like_growth_factor_II _ -LRB- IGF-II -RRB- - mediated signaling ; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells .
17369847	0	IGF-II	0,6	PTEN	43,47	IGF-II	PTEN	3481	5728	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	IGF-II and IGFBP-2 differentially regulate PTEN in human breast_cancer cells .
10585285	0	IGF-II	0,6	TGFbeta1	39,47	IGF-II	TGFbeta1	3481	7040	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	IGF-II enhances trichostatin_A-induced TGFbeta1 and p21 -LRB- Waf1 , Cip1 , sdi1 -RRB- expression in Hep3B cells .
19896952	0	IGF-II	53,59	insulin-degrading_enzyme	92,116	IGF-II	insulin-degrading enzyme	3481	3416	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis for the recognition and cleavages of IGF-II , TGF-alpha , and amylin by human insulin-degrading_enzyme .
1649393	0	IGF-II	142,148	insulin-like_growth_factor-I	37,65	IGF-II	insulin-like growth factor-I	3481	3479	Gene	Gene	role|nmod|START_ENTITY Progestins|dep|role Progestins|dep|induce induce|dobj|down-regulation down-regulation|nmod|END_ENTITY	Progestins induce down-regulation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors in human breast_cancer cells : potential autocrine role of IGF-II .
1715381	0	IGF-II	53,59	insulin-like_growth_factor-I	15,43	IGF-II	insulin-like growth factor-I	24483(Tax:10116)	24482(Tax:10116)	Gene	Gene	IGF-I|compound|START_ENTITY effects|appos|IGF-I effects|nmod|END_ENTITY	The effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I , a potent IGF analogue , on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells .
2005410	0	IGF-II	91,97	insulin-like_growth_factor-I	53,81	IGF-II	insulin-like growth factor-I	24483(Tax:10116)	24482(Tax:10116)	Gene	Gene	IGF-I|nsubj|START_ENTITY IGF-I|nsubj|clearance clearance|nmod|END_ENTITY	Plasma clearance and tissue distribution of labelled insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I in rats .
2172801	0	IGF-II	137,143	insulin-like_growth_factor-I	20,48	IGF-II	insulin-like growth factor-I	24483(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY comparison|nmod|expression pattern|dep|comparison pattern|nmod|END_ENTITY	Cellular pattern of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and type I IGF receptor gene expression in early organogenesis : comparison with IGF-II gene expression .
8077342	0	IGF-II	77,83	insulin-like_growth_factor-I	14,42	IGF-II	insulin-like growth factor-I	3481	3479	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-II and the IGF-I , IGF-II , and insulin_receptor genes and localization of the gene products in the human ovary .
8188767	0	IGF-II	226,232	insulin-like_growth_factor-I	47,75	IGF-II	insulin-like growth factor-I	3481	3479	Gene	Gene	stimulation|nmod|START_ENTITY /|dep|stimulation /|nsubj|END_ENTITY	Human_osteosarcoma -LRB- U-2_OS -RRB- cells express both insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors and insulin-like_growth_factor-II / mannose-6-phosphate -LRB- IGF-II/M6P -RRB- receptors and synthesize IGF-II : autocrine growth stimulation by IGF-II via the IGF-I_receptor .
22726701	0	IGF-II	10,16	insulin-like_growth_factor-II	18,47	IGF-II	insulin-like growth factor-II	3481	3481	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of IGF-II -LRB- insulin-like_growth_factor-II -RRB- genotype on the quality of dry-cured hams and shoulders .
10404828	0	IGF-II	64,70	insulin-like_growth_factor_I	24,52	IGF-II	insulin-like growth factor I	3481	3479	Gene	Gene	synthesis|amod|START_ENTITY regulation|dep|synthesis regulation|nmod|END_ENTITY	Paracrine regulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- an IGF-II on prostaglandins_F2alpha and E2 synthesis by human corpus luteum in vitro : a possible balance of luteotropic and luteolytic effects .
11095464	0	IGF-II	54,60	insulin-like_growth_factor_I	16,44	IGF-II	insulin-like growth factor I	3481	3479	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , IGF-binding_protein-3 , and prostate-specific_antigen as predictors of clinical prostate_cancer .
7588270	0	IGF-II	86,92	insulin-like_growth_factor_I	48,76	IGF-II	insulin-like growth factor I	3481	3479	Gene	Gene	acids|amod|START_ENTITY acids|nmod|END_ENTITY	Localization of messenger ribonucleic acids for insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , and the type 1 IGF receptor in the ovine ovary throughout the estrous cycle .
17556377	0	IGF-II	0,6	insulin_receptor	94,110	IGF-II	insulin receptor	3481	3643	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin_receptor .
9281335	0	IGF-II	32,38	insulin_receptor	48,64	IGF-II	insulin receptor	16002(Tax:10090)	16337(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Growth-promoting interaction of IGF-II with the insulin_receptor during mouse embryonic development .
8667333	0	IGF-II_and_type-I_IGF_receptor	38,68	IGF-I	30,35	IGF-II and type-I IGF receptor	IGF-I	3481	3479	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II_and_type-I_IGF_receptor gene expression in the ovary of the laying hen .
12556535	0	IGF-IR	44,50	ASK1	109,113	IGF-IR	ASK1	3480	4217	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Type 1 insulin-like_growth_factor receptor -LRB- IGF-IR -RRB- signaling inhibits apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- .
23607268	0	IGF-IR	36,42	Akt	18,21	IGF-IR	Akt	3480	207	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Decorin activates Akt downstream of IGF-IR and promotes myoblast differentiation .
11571630	0	IGF-IR	39,45	Bcl-2	0,5	IGF-IR	Bcl-2	3480	596	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Bcl-2 and M-Myc coexpression increases IGF-IR and features of malignant growth in neuroblastoma cell lines .
22777769	0	IGF-IR	67,73	Bmi-1	32,37	IGF-IR	Bmi-1	3480	648	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	VEGF/neuropilin -2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive_prostate_cancer .
11507082	0	IGF-IR	188,194	IGF-I	161,166	IGF-IR	IGF-I	3480	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	In vivo progression of LAPC-9 and LNCaP prostate_cancer models to androgen independence is associated with increased expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-I_receptor -LRB- IGF-IR -RRB- .
25777566	0	IGF-IR	53,59	Ik-1	26,30	IGF-IR	Ik-1	3480	10320	Gene	Gene	expression|compound|START_ENTITY downregulate|dobj|expression downregulate|nsubj|END_ENTITY	The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK -LRB- + -RRB- T-cell_lymphoma .
25884514	0	IGF-IR	53,59	Ik-1	26,30	IGF-IR	Ik-1	3480	10320	Gene	Gene	expression|compound|START_ENTITY downregulate|dobj|expression downregulate|nsubj|END_ENTITY	The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK -LRB- + -RRB- T-cell_lymphoma .
17127062	0	IGF-IR	84,90	insulin-like_growth-factor-I_receptor	45,82	IGF-IR	insulin-like growth-factor-I receptor	3480	3480	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	1,3-Disubstituted-imidazo -LSB- 1,5-a -RSB- pyrazines as insulin-like_growth-factor-I_receptor -LRB- IGF-IR -RRB- inhibitors .
12556535	0	IGF-IR	44,50	insulin-like_growth_factor	7,33	IGF-IR	insulin-like growth factor	3480	3479	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Type 1 insulin-like_growth_factor receptor -LRB- IGF-IR -RRB- signaling inhibits apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- .
21075859	0	IGF-IR	204,210	insulin-like_growth_factor-I	54,82	IGF-IR	insulin-like growth factor-I	3480	3479	Gene	Gene	phosphorylation|compound|START_ENTITY down-regulation|nmod|phosphorylation induced|nmod|down-regulation END_ENTITY|acl:relcl|induced	Dopamine , by acting through its D2 receptor , inhibits insulin-like_growth_factor-I -LRB- IGF-I -RRB- - induced gastric_cancer cell proliferation via up-regulation of Kr ppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation .
21782884	0	IGF-IR	57,63	insulin-like_growth_factor-I	18,46	IGF-IR	insulin-like growth factor-I	3480	3479	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Plasma and tissue insulin-like_growth_factor-I receptor -LRB- IGF-IR -RRB- as a prognostic marker for prostate_cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases : a review .
16730884	0	IGF-IR	148,154	insulin-like_growth_factor-I_receptor	109,146	IGF-IR	insulin-like growth factor-I receptor	3480	3480	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel EWS-WT1 gene fusion product in desmoplastic_small_round_cell_tumor is a potent transactivator of the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- gene .
16968249	0	IGF-IR	75,81	insulin-like_growth_factor-I_receptor	36,73	IGF-IR	insulin-like growth factor-I receptor	25718(Tax:10116)	25718(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- in the developing and mature rat testes .
17766039	0	IGF-IR	48,54	insulin-like_growth_factor-I_receptor	9,46	IGF-IR	insulin-like growth factor-I receptor	3480	3480	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Elevated insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- levels in primary breast_tumors associated with BRCA1 mutations .
17950526	0	IGF-IR	132,138	insulin-like_growth_factor-I_receptor	93,130	IGF-IR	insulin-like growth factor-I receptor	3480	3480	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human pancreatic_carcinoma cells by the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- system .
17983756	0	IGF-IR	109,115	insulin-like_growth_factor-I_receptor	70,107	IGF-IR	insulin-like growth factor-I receptor	3480	3480	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Novel 2-phenylquinolin-7-yl-derived imidazo -LSB- 1,5-a -RSB- pyrazines as potent insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- inhibitors .
19703789	0	IGF-IR	99,105	insulin-like_growth_factor-I_receptor	60,97	IGF-IR	insulin-like growth factor-I receptor	3480	3480	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcription factor E2F1 is a potent transactivator of the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- gene .
25980584	0	IGF-IR	151,157	insulin-like_growth_factor-I_receptor	112,149	IGF-IR	insulin-like growth factor-I receptor	3480	3480	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- signaling .
26595309	0	IGF-IR	63,69	insulin-like_growth_factor_I_receptor	24,61	IGF-IR	insulin-like growth factor I receptor	16001(Tax:10090)	16001(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The role of selenium in insulin-like_growth_factor_I_receptor -LRB- IGF-IR -RRB- expression and regulation of apoptosis in mouse osteoblasts .
23950756	0	IGF-I_Receptor	96,110	IGF-I	0,5	IGF-I Receptor	IGF-I	16001(Tax:10090)	16000(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY Stimulate|advcl|Binding Stimulate|nsubj|END_ENTITY	IGF-I , IGF-II , and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I_Receptor .
12688134	0	IGF-I_binding_protein_3	69,92	growth_hormone	41,55	IGF-I binding protein 3	growth hormone	3486	2688	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	-LSB- Effect of various doses of biosynthetic growth_hormone on levels of IGF-I_binding_protein_3 -LRB- IGFBP-3 -RRB- in patients with hypopituitarism and growth_hormone deficiency -RSB- .
10583412	0	IGF-I_receptor	126,140	IGF-I	30,35	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	activation|amod|START_ENTITY occurs|nmod|activation kinase|dep|occurs activation|nmod|kinase Insulin-like_growth_factor-I|dep|activation Insulin-like_growth_factor-I|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- - dependent activation of pp42/44 mitogen-activated_protein kinase occurs independently of IGF-I_receptor kinase activation and IRS-1 tyrosine phosphorylation .
11245675	0	IGF-I_receptor	129,143	IGF-I	30,35	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|Insulin-like_growth_factor_I Insulin-like_growth_factor_I|appos|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- protects cells from apoptosis by Alzheimer 's V642I mutant amyloid_precursor_protein through IGF-I_receptor in an IGF-binding protein-sensitive manner .
14691011	0	IGF-I_receptor	112,126	IGF-I	105,110	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	circuit|amod|START_ENTITY Inhibition|parataxis|circuit Inhibition|nmod|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like_growth_factor_I -LRB- IGF-I -RRB- / IGF-I_receptor autocrine circuit .
14723884	0	IGF-I_receptor	71,85	IGF-I	64,69	IGF-I receptor	IGF-I	281848(Tax:9913)	104978413	Gene	Gene	effects|appos|START_ENTITY effects|nmod|somatotropin somatotropin|nmod|END_ENTITY	The effects of recombinant bovine somatotropin -LRB- rbST -RRB- on tissue IGF-I , IGF-I_receptor , and GH mRNA levels in rainbow_trout , Oncorhynchus_mykiss .
16728156	0	IGF-I_receptor	125,139	IGF-I	94,99	IGF-I receptor	IGF-I	281848(Tax:9913)	104978413	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Stimulation Stimulation|appos|END_ENTITY	Stimulation of the development of bovine embryos by insulin_and_insulin-like_growth_factor-I -LRB- IGF-I -RRB- is mediated through the IGF-I_receptor .
17761895	0	IGF-I_receptor	20,34	IGF-I	101,106	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	gene|amod|START_ENTITY Inactivation|nmod|gene highlights|nsubj|Inactivation highlights|dobj|effects effects|nmod|END_ENTITY	Inactivation of the IGF-I_receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I .
17945524	0	IGF-I_receptor	21,35	IGF-I	0,5	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	IGF-I binding to the IGF-I_receptor is affected by contaminants in commercial BSA : the contaminants are proteins with IGF-I binding properties .
17945524	0	IGF-I_receptor	21,35	IGF-I	118,123	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	binding|nmod|START_ENTITY affected|nsubjpass|binding affected|parataxis|proteins proteins|nmod|properties properties|amod|END_ENTITY	IGF-I binding to the IGF-I_receptor is affected by contaminants in commercial BSA : the contaminants are proteins with IGF-I binding properties .
21799000	0	IGF-I_receptor	53,67	IGF-I	0,5	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	interaction|nmod|START_ENTITY stimulates|dobj|interaction stimulates|nsubj|END_ENTITY	IGF-I stimulates cooperative interaction between the IGF-I_receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells .
2580525	0	IGF-I_receptor	49,63	IGF-I	77,82	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	antibodies|nmod|START_ENTITY Characterization|nmod|antibodies END_ENTITY|nsubj|Characterization	Characterization of monoclonal antibodies to the IGF-I_receptor that inhibit IGF-I binding to human cells .
25947141	0	IGF-I_receptor	23,37	IGF-I	92,97	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	activity|amod|START_ENTITY circulating|dobj|activity Changes|acl|circulating parallel|nsubj|Changes parallel|dobj|changes changes|nmod|END_ENTITY	Changes in circulating IGF-I_receptor stimulating activity do not parallel changes in Total IGF-I during GH treatment of GH-deficient adults .
7505467	0	IGF-I_receptor	70,84	IGF-I	30,35	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Insulin-like growth factor-I -LRB- IGF-I -RRB- dependent phosphorylation of the IGF-I_receptor in MG-63 cells .
7514345	0	IGF-I_receptor	54,68	IGF-I	31,36	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	analogs|nmod|START_ENTITY analogs|nsubj|Analysis Analysis|nmod|interaction interaction|nmod|END_ENTITY	Analysis of the interaction of IGF-I analogs with the IGF-I_receptor and IGF binding proteins .
7522208	0	IGF-I_receptor	85,99	IGF-I	61,66	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	proteins|compound|START_ENTITY analogs|nmod|proteins analogs|nsubj|Analysis Analysis|appos|END_ENTITY	Analysis of the interaction of insulin-like_growth_factor_I -LRB- IGF-I -RRB- analogs with the IGF-I_receptor and IGF-binding proteins .
7544271	0	IGF-I_receptor	163,177	IGF-I	59,64	IGF-I receptor	IGF-I	281848(Tax:9913)	104978413	Gene	Gene	proteins|compound|START_ENTITY interaction|nmod|proteins cells|dep|interaction stimulating|nmod|cells END_ENTITY|advcl|stimulating	Insulin-like_growth_factor_II _ -LRB- IGF-II -RRB- is more potent than IGF-I in stimulating cortisol secretion from cultured bovine adrenocortical cells : interaction with the IGF-I_receptor and IGF-binding proteins .
8188767	0	IGF-I_receptor	241,255	IGF-I	77,82	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	IGF-II|nmod|START_ENTITY stimulation|nmod|IGF-II /|dep|stimulation /|nsubj|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Human_osteosarcoma -LRB- U-2_OS -RRB- cells express both insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors and insulin-like_growth_factor-II / mannose-6-phosphate -LRB- IGF-II/M6P -RRB- receptors and synthesize IGF-II : autocrine growth stimulation by IGF-II via the IGF-I_receptor .
8722694	0	IGF-I_receptor	70,84	IGF-I	0,5	IGF-I receptor	IGF-I	16001(Tax:10090)	16000(Tax:10090)	Gene	Gene	blastocysts|nmod|START_ENTITY regulate|nmod|blastocysts regulate|nsubj|END_ENTITY	IGF-I and insulin regulate glucose transport in mouse blastocysts via IGF-I_receptor .
9721859	0	IGF-I_receptor	95,109	IGF-I	45,50	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	number|amod|START_ENTITY proliferation|nmod|number insulin-like_growth_factor_I|dep|proliferation insulin-like_growth_factor_I|appos|END_ENTITY	Src stimulates insulin-like_growth_factor_I -LRB- IGF-I -RRB- - dependent cell proliferation by increasing IGF-I_receptor number in human pancreatic_carcinoma cells .
9846170	0	IGF-I_receptor	212,226	IGF-I	105,110	IGF-I receptor	IGF-I	3480	3479	Gene	Gene	proteins|compound|START_ENTITY interaction|nmod|proteins enhance|nmod|interaction enhance|nsubj|Regulation Regulation|nmod|steroidogenesis steroidogenesis|nmod|factors factors|dep|END_ENTITY	Regulation of steroidogenesis by insulin-like growth factors -LRB- IGFs -RRB- in adult human adrenocortical cells : IGF-I and , more potently , IGF-II preferentially enhance androgen biosynthesis through interaction with the IGF-I_receptor and IGF-binding proteins .
22738321	0	IGF-I_receptor	99,113	IGF1R	115,120	IGF-I receptor	IGF1R	3480	3480	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Familial_short_stature and intrauterine_growth_retardation associated with a novel mutation in the IGF-I_receptor -LRB- IGF1R -RRB- gene .
11245675	0	IGF-I_receptor	129,143	Insulin-like_growth_factor_I	0,28	IGF-I receptor	Insulin-like growth factor I	3480	3479	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- protects cells from apoptosis by Alzheimer 's V642I mutant amyloid_precursor_protein through IGF-I_receptor in an IGF-binding protein-sensitive manner .
15055356	0	IGF-I_receptor	86,100	Signal_transducer_and_activator_of_transcription-1	0,50	IGF-I receptor	Signal transducer and activator of transcription-1	3480	6772	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Signal_transducer_and_activator_of_transcription-1 -LRB- STAT1 -RRB- , but not STAT5b , regulates IGF-I_receptor gene expression in an osteosarcoma cell line .
25514442	0	IGF-R1	81,87	TGFb1	58,63	IGF-R1	TGFb1	25718(Tax:10116)	59086(Tax:10116)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Chronic lung_injury in the neonatal rat : Up-regulation of TGFb1 and nitration of IGF-R1 by peroxynitrite as likely contributors to impaired alveologenesis .
9768663	0	IGF-binding_protein-1	47,68	IGF-I	39,44	IGF-binding protein-1	IGF-I	3484	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Insulin , insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-1 , growth_hormone , and feeding in the newborn .
7684393	0	IGF-binding_protein-1	60,81	Insulin-like_growth_factor-I	0,28	IGF-binding protein-1	Insulin-like growth factor-I	3484	3479	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- inhibits production of IGF-binding_protein-1 while stimulating estradiol secretion in granulosa cells from normal and polycystic human ovaries .
15126555	0	IGF-binding_protein-3	105,126	IGF-I	97,102	IGF-binding protein-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Sustained elevation of pulsatile growth_hormone -LRB- GH -RRB- secretion and insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women .
18780604	0	IGF-binding_protein-3	44,65	IGF-I	36,41	IGF-binding protein-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-3 , and growth_hormone levels in collodion babies : a case-control study .
7530256	0	IGF-binding_protein-3	49,70	IGF-I	41,46	IGF-binding protein-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Changes in insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-3 , growth hormone -LRB- GH -RRB- - binding protein , erythrocyte IGF-I_receptors , and growth rate during GH treatment .
10700718	0	IGF-binding_protein-3	38,59	IGFBP-3	61,68	IGF-binding protein-3	IGFBP-3	3486	3486	Gene	Gene	serum|nummod|START_ENTITY efficiency|nmod|serum efficiency|appos|END_ENTITY	Diagnostic efficiency of serum IGF-I , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and urinary GH measurements in the diagnosis of adult_GH_deficiency : importance of an appropriate reference population .
19019211	0	IGF-binding_protein_7	12,33	IGFBP7	35,41	IGF-binding protein 7	IGFBP7	3490	3490	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Circulating IGF-binding_protein_7 -LRB- IGFBP7 -RRB- levels are elevated in patients with endometriosis or undergoing diabetic_hemodialysis .
20610598	0	IGF-binding_proteins_2_and_3	44,72	IGF-I	36,41	IGF-binding proteins 2 and 3	IGF-I	3485;3486	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_proteins_2_and_3 , and the risk for development of malignancies in adults with growth_hormone -LRB- GH -RRB- deficiency treated with GH : data from KIMS -LRB- Pfizer International Metabolic Database -RRB- .
21750148	0	IGF1	12,16	IGF1	39,43	IGF1	IGF1	3479	3479	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence .
21750148	0	IGF1	39,43	IGF1	12,16	IGF1	IGF1	3479	3479	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence .
25520502	0	IGF1	58,62	IGF1	88,92	IGF1	IGF1	3479	3479	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|Receptor Receptor|compound|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
25520502	0	IGF1	88,92	IGF1	58,62	IGF1	IGF1	3479	3479	Gene	Gene	Receptor|compound|START_ENTITY Expression|nmod|Receptor Expression|appos|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
22351760	0	IGF1	114,118	IGF1R	76,81	IGF1	IGF1R	3479	3480	Gene	Gene	binding|nmod|START_ENTITY formation|amod|binding direct|dobj|formation direct|nsubj|Cross-talk Cross-talk|nmod|a6b4 a6b4|appos|END_ENTITY	Cross-talk between integrin a6b4 and insulin-like_growth_factor-1 receptor -LRB- IGF1R -RRB- through direct a6b4 binding to IGF1 and subsequent a6b4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions .
23696648	0	IGF1	132,136	IGF1R	147,152	IGF1	IGF1R	3479	3480	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	An integrin binding-defective mutant of insulin-like_growth_factor-1 -LRB- R36E/R37E IGF1 -RRB- acts as a dominant-negative antagonist of the IGF1 receptor -LRB- IGF1R -RRB- and suppresses tumorigenesis but still binds to IGF1R .
23696648	0	IGF1	80,84	IGF1R	147,152	IGF1	IGF1R	3479	3480	Gene	Gene	acts|appos|START_ENTITY mutant|nmod|acts mutant|nmod|antagonist antagonist|nmod|receptor receptor|appos|END_ENTITY	An integrin binding-defective mutant of insulin-like_growth_factor-1 -LRB- R36E/R37E IGF1 -RRB- acts as a dominant-negative antagonist of the IGF1 receptor -LRB- IGF1R -RRB- and suppresses tumorigenesis but still binds to IGF1R .
25344917	0	IGF1	99,103	IGF1R	76,81	IGF1	IGF1R	3479	3480	Gene	Gene	elevation|nmod|START_ENTITY END_ENTITY|nmod|elevation	TM4SF4 overexpression in radiation-resistant lung_carcinoma cells activates IGF1R via elevation of IGF1 .
20472501	0	IGF1	30,34	IGF_binding_protein_3	37,58	IGF1	IGF binding protein 3	3479	3486	Gene	Gene	Insulin-like_growth_factor_1|appos|START_ENTITY Insulin-like_growth_factor_1|appos|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF1 -RRB- , IGF_binding_protein_3 -LRB- IGFBP3 -RRB- , and breast_cancer risk : pooled individual data analysis of 17 prospective studies .
25520502	0	IGF1	58,62	Insulin-Like_Growth_Factor_1	28,56	IGF1	Insulin-Like Growth Factor 1	3479	3479	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
23089282	0	IGF1	30,34	Insulin-like_growth_factor_1	0,28	IGF1	Insulin-like growth factor 1	3479	3479	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF1 -RRB- polymorphism is associated with Alzheimer 's _ disease in Han Chinese .
23497056	0	IGF1	36,40	Insulin-like_growth_factor_1_and_2	0,34	IGF1	Insulin-like growth factor 1 and 2	3479	3481;3479	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor_1_and_2 -LRB- IGF1 , IGF2 -RRB- expression in human microglia : differential regulation by inflammatory mediators .
25520502	0	IGF1	58,62	LMP1	0,4	IGF1	LMP1	3479	9260	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
25520502	0	IGF1	88,92	LMP1	0,4	IGF1	LMP1	3479	9260	Gene	Gene	Receptor|compound|START_ENTITY Expression|nmod|Receptor Expression|compound|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
17560942	0	IGF1	80,84	XBP-1	0,5	IGF1	XBP-1	114433(Tax:7955)	140614(Tax:7955)	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	XBP-1 , a key regulator of unfolded protein response , activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line .
25966067	0	IGF1	98,102	insulin-like_growth_factor-1	68,96	IGF1	insulin-like growth factor-1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Associations between genetic variants in the promoter region of the insulin-like_growth_factor-1 -LRB- IGF1 -RRB- gene and blood serum IGF1 concentration in Hanwoo cattle .
21471200	0	IGF1	45,49	insulin-like_growth_factor_1	15,43	IGF1	insulin-like growth factor 1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Foxo1 mediates insulin-like_growth_factor_1 -LRB- IGF1 -RRB- / insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts .
22357625	0	IGF1	46,50	insulin-like_growth_factor_1	16,44	IGF1	insulin-like growth factor 1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mex3c regulates insulin-like_growth_factor_1 -LRB- IGF1 -RRB- expression and promotes postnatal growth .
26059224	0	IGF1	61,65	insulin-like_growth_factor_1	31,59	IGF1	insulin-like growth factor 1	418090(Tax:9031)	418090(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism and expression of insulin-like_growth_factor_1 -LRB- IGF1 -RRB- gene and its association with growth traits in chicken .
3517163	0	IGF1	65,69	insulin_and_insulin-like_growth_factor-1	23,63	IGF1	insulin and insulin-like growth factor-1	3479	3630;3479	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Suppressive effects of insulin_and_insulin-like_growth_factor-1 -LRB- IGF1 -RRB- on immune responses .
2544239	0	IGF1-R	60,66	insulin-like_growth_factor_1_receptors	20,58	IGF1-R	insulin-like growth factor 1 receptors	3480	3480	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of insulin-like_growth_factor_1_receptors -LRB- IGF1-R -RRB- in human breast_cancer cell lines .
21340604	0	IGF1R	30,35	BRAF	18,22	IGF1R	BRAF	3480	673	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
22738321	0	IGF1R	115,120	IGF-I_receptor	99,113	IGF1R	IGF-I receptor	3480	3480	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Familial_short_stature and intrauterine_growth_retardation associated with a novel mutation in the IGF-I_receptor -LRB- IGF1R -RRB- gene .
22351760	0	IGF1R	76,81	IGF1	114,118	IGF1R	IGF1	3480	3479	Gene	Gene	a6b4|appos|START_ENTITY Cross-talk|nmod|a6b4 direct|nsubj|Cross-talk direct|dobj|formation formation|amod|binding binding|nmod|END_ENTITY	Cross-talk between integrin a6b4 and insulin-like_growth_factor-1 receptor -LRB- IGF1R -RRB- through direct a6b4 binding to IGF1 and subsequent a6b4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions .
23696648	0	IGF1R	147,152	IGF1	132,136	IGF1R	IGF1	3480	3479	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	An integrin binding-defective mutant of insulin-like_growth_factor-1 -LRB- R36E/R37E IGF1 -RRB- acts as a dominant-negative antagonist of the IGF1 receptor -LRB- IGF1R -RRB- and suppresses tumorigenesis but still binds to IGF1R .
23696648	0	IGF1R	147,152	IGF1	80,84	IGF1R	IGF1	3480	3479	Gene	Gene	receptor|appos|START_ENTITY antagonist|nmod|receptor mutant|nmod|antagonist mutant|nmod|acts acts|appos|END_ENTITY	An integrin binding-defective mutant of insulin-like_growth_factor-1 -LRB- R36E/R37E IGF1 -RRB- acts as a dominant-negative antagonist of the IGF1 receptor -LRB- IGF1R -RRB- and suppresses tumorigenesis but still binds to IGF1R .
25344917	0	IGF1R	76,81	IGF1	99,103	IGF1R	IGF1	3480	3479	Gene	Gene	START_ENTITY|nmod|elevation elevation|nmod|END_ENTITY	TM4SF4 overexpression in radiation-resistant lung_carcinoma cells activates IGF1R via elevation of IGF1 .
23831640	0	IGF1R	46,51	IGFBP-3	28,35	IGF1R	IGFBP-3	3480	3486	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|expression expression|nmod|END_ENTITY	TGF-b-induced expression of IGFBP-3 regulates IGF1R signaling in human osteosarcoma cells .
26265685	0	IGF1R	50,55	Insulin-like_Growth_Factor-1_Receptor	11,48	IGF1R	Insulin-like Growth Factor-1 Receptor	3480	3480	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Membranous Insulin-like_Growth_Factor-1_Receptor -LRB- IGF1R -RRB- Expression Is Predictive of Poor Prognosis in Patients with Epidermal_Growth_Factor_Receptor -LRB- <i> EGFR </i> -RRB- - Mutant Lung Adenocarcinoma .
26475121	0	IGF1R	39,44	Insulin-like_growth_factor_1_receptor	0,37	IGF1R	Insulin-like growth factor 1 receptor	3480	3480	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification .
19767315	0	IGF1R	39,44	Insulin-like_growth_factor_receptor_1	0,37	IGF1R	Insulin-like growth factor receptor 1	3480	3480	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor_receptor_1 -LRB- IGF1R -RRB- expression and survival in surgically resected non-small-cell_lung_cancer -LRB- NSCLC -RRB- patients .
21340604	0	IGF1R	30,35	KRAS	12,16	IGF1R	KRAS	3480	3845	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
22261717	0	IGF1R	8,13	LEF1/TCF	51,59	IGF1R	LEF1/TCF	3480	51176;3172	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF .
23056576	0	IGF1R	84,89	MiR-122	0,7	IGF1R	MiR-122	3480	406906	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-122 inhibits cell proliferation and tumorigenesis of breast_cancer by targeting IGF1R .
25474488	0	IGF1R	29,34	MiR-143	0,7	IGF1R	MiR-143	3480	406935	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal_cancer .
24931256	0	IGF1R	87,92	MiR-503	0,7	IGF1R	MiR-503	3480	574506	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-503 regulates cisplatin resistance of human gastric_cancer cell lines by targeting IGF1R and BCL2 .
15499378	0	IGF1R	17,22	PTEN	80,84	IGF1R	PTEN	3480	5728	Gene	Gene	gene|compound|START_ENTITY Silencing|nmod|gene enhances|nsubj|Silencing enhances|nmod|agents agents|nmod|wild-type wild-type|compound|END_ENTITY	Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate_cancer .
21340604	0	IGF1R	30,35	PTEN	24,28	IGF1R	PTEN	3480	5728	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
17442315	0	IGF1R	92,97	insulin-like_growth_factor-1_receptor	53,90	IGF1R	insulin-like growth factor-1 receptor	3480	3480	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the GAA1013 -- > GAG polymorphism of the insulin-like_growth_factor-1_receptor -LRB- IGF1R -RRB- gene with premature_pubarche .
21494688	0	IGF1R	106,111	insulin-like_growth_factor_1_receptor	67,104	IGF1R	insulin-like growth factor 1 receptor	3480	3480	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Targeted morphoproteomic profiling of Ewing 's _ sarcoma treated with insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- inhibitors : response/resistance signatures .
23780396	0	IGF1R	91,96	insulin-like_growth_factor_1_receptor	52,89	IGF1R	insulin-like growth factor 1 receptor	281848(Tax:9913)	281848(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of two SNPs in the coding region of the insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- gene with growth-related traits in Angus cattle .
24033502	0	IGF1R	120,125	insulin-like_growth_factor_1_receptor	81,118	IGF1R	insulin-like growth factor 1 receptor	3480	3480	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Familial_short_stature is associated with a novel dominant-negative heterozygous insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- mutation .
24392142	0	IGF1R	90,95	insulin-like_growth_factor_1_receptor	51,88	IGF1R	insulin-like growth factor 1 receptor	3480	3480	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of polymorphisms and haplotypes in the insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- gene with the risk of breast_cancer in Korean women .
21695430	0	IGF1R	165,170	insulin-like_growth_factor_receptor	128,163	IGF1R	insulin-like growth factor receptor	397350(Tax:9823)	397350(Tax:9823)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Study of the differential transcription in liver of growth_hormone_receptor -LRB- GHR -RRB- , insulin-like growth factors -LRB- IGF1 , IGF2 -RRB- and insulin-like_growth_factor_receptor -LRB- IGF1R -RRB- genes at different postnatal developmental ages in pig breeds .
24875127	0	IGF1R	88,93	miR-1271	0,8	IGF1R	miR-1271	3480	100302203	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-1271 regulates cisplatin resistance of human gastric_cancer cell lines by targeting IGF1R , IRS1 , mTOR , and BCL2 .
25609710	0	IGF1R	101,106	miR-145	0,7	IGF1R	miR-145	3480	406937	Gene	Gene	modulating|dobj|START_ENTITY suppresses|advcl|modulating suppresses|nsubj|END_ENTITY	miR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R .
24874051	0	IGF1R	71,76	miR-195	0,7	IGF1R	miR-195	3480	406971	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-195 inhibits the growth and metastasis of NSCLC cells by targeting IGF1R .
25184138	0	IGF1R	19,24	miR-375	0,7	IGF1R	miR-375	3480	494324	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	miR-375 suppresses IGF1R expression and contributes to inhibition of cell progression in laryngeal_squamous_cell_carcinoma .
24655723	0	IGF1R	16,21	miR-630	0,7	IGF1R	miR-630	3480	693215	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast_cancer .
12960026	0	IGF2	51,55	CTCF	0,4	IGF2	CTCF	3481	10664	Gene	Gene	insulin-like_growth_factor-II|appos|START_ENTITY binding|nmod|insulin-like_growth_factor-II binding|compound|END_ENTITY	CTCF binding at the insulin-like_growth_factor-II -LRB- IGF2 -RRB- / H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues .
25670076	0	IGF2	84,88	GATA2	64,69	IGF2	GATA2	3481	2624	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Taxane Resistance in Prostate_Cancer Mediated by AR-Independent GATA2 Regulation of IGF2 .
17600088	0	IGF2	28,32	Integrin_alpha_11	0,17	IGF2	Integrin alpha 11	3481	22801	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Integrin_alpha_11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell_lung_cancer cells .
8821886	0	IGF2	69,73	SNRPN	135,140	IGF2	SNRPN	3481	6638	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Maintenance of imprinting of the insulin-like growth factor II gene -LRB- IGF2 -RRB- and the small_nuclear_ribonucleoprotein_polypeptide_N gene -LRB- SNRPN -RRB- in the human uterus and leiomyoma .
24469060	0	IGF2	49,53	ZFP57	35,40	IGF2	ZFP57	3481	346171	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells .
11717330	0	IGF2	53,57	insulin-like_growth_factor-II	22,51	IGF2	insulin-like growth factor-II	3481	3481	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Loss of imprinting of insulin-like_growth_factor-II -LRB- IGF2 -RRB- gene in distinguishing specific biologic subtypes of Wilms_tumor .
16330588	0	IGF2	59,63	insulin-like_growth_factor_2	24,52	IGF2	insulin-like growth factor 2	3481	3481	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the insulin-like_growth_factor_2 gene -LRB- IGF2 -RRB- and scores on the Eating Attitudes Test in nonclinical subjects : a family-based study .
19785908	0	IGF2	85,89	insulin-like_growth_factor_2	54,82	IGF2	insulin-like growth factor 2	281240(Tax:9913)	281240(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of polymorphisms in exons 2 and 10 of the insulin-like_growth_factor_2 -LRB- IGF2 -RRB- gene with milk production traits in Polish Holstein-Friesian cattle .
24173291	0	IGF2	34,38	insulin-like_growth_factor_2	4,32	IGF2	insulin-like growth factor 2	3481	3481	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The insulin-like_growth_factor_2 -LRB- IGF2 -RRB- mRNA-binding protein p62/IGF2BP2 -2 as a promoter of NAFLD and HCC ?
27083047	0	IGF2	97,101	insulin-like_growth_factor_2	67,95	IGF2	insulin-like growth factor 2	3481	3481	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Retrograde fibroblast_growth_factor_22 -LRB- FGF22 -RRB- signaling regulates insulin-like_growth_factor_2 -LRB- IGF2 -RRB- expression for activity-dependent synapse stabilization in the mammalian brain .
23035551	0	IGF2	51,55	insulin-like_growth_factor_II	20,49	IGF2	insulin-like growth factor II	3481	3481	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Association of the insulin-like_growth_factor_II -LRB- IGF2 -RRB- gene with human cognitive functions -RSB- .
9376897	0	IGF2	52,56	insulin-like_growth_factor_II	21,50	IGF2	insulin-like growth factor II	3481	3481	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Apal polymorphism in insulin-like_growth_factor_II -LRB- IGF2 -RRB- gene and weight in middle-aged males .
22926517	0	IGF2	19,23	miR-100	0,7	IGF2	miR-100	3481	406892	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling .
26692944	0	IGF2BP1	61,68	miR-506	0,7	IGF2BP1	miR-506	10642	574511	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma .
25889892	0	IGF2BP1	89,96	miRNA-196b	0,10	IGF2BP1	miRNA-196b	10642	442920	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1 .
25889892	0	IGF2BP1	89,96	miRNA-196b	0,10	IGF2BP1	miRNA-196b	10642	442920	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1 .
18597214	0	IGF2BP2	23,30	CDKAL1	32,38	IGF2BP2	CDKAL1	10644	54901	Gene	Gene	HHEX|nummod|START_ENTITY HHEX|nummod|END_ENTITY	Variants of the PPARG , IGF2BP2 , CDKAL1 , HHEX , and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies .
18633108	0	IGF2BP2	37,44	CDKAL1	19,25	IGF2BP2	CDKAL1	10644	54901	Gene	Gene	SLC30A8|appos|START_ENTITY SLC30A8|compound|END_ENTITY	Common variants in CDKAL1 , CDKN2A/B , IGF2BP2 , SLC30A8 , and HHEX/IDE genes are associated with type 2 diabetes and impaired_fasting_glucose in a Chinese Han population .
19008344	0	IGF2BP2	76,83	CDKAL1	47,53	IGF2BP2	CDKAL1	10644	54901	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	IGF2BP2	70,77	CDKAL1	52,58	IGF2BP2	CDKAL1	10644	54901	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18633108	0	IGF2BP2	37,44	CDKN2A/B	27,35	IGF2BP2	CDKN2A/B	10644	1029;1030	Gene	Gene	SLC30A8|appos|START_ENTITY SLC30A8|appos|END_ENTITY	Common variants in CDKAL1 , CDKN2A/B , IGF2BP2 , SLC30A8 , and HHEX/IDE genes are associated with type 2 diabetes and impaired_fasting_glucose in a Chinese Han population .
20509872	0	IGF2BP2	70,77	CDKN2A/B	60,68	IGF2BP2	CDKN2A/B	10644	1029;1030	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19008344	0	IGF2BP2	76,83	EXT2	70,74	IGF2BP2	EXT2	10644	2132	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	IGF2BP2	76,83	FTO	42,45	IGF2BP2	FTO	10644	79068	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|compound|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	IGF2BP2	70,77	FTO	79,82	IGF2BP2	FTO	10644	79068	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19008344	0	IGF2BP2	76,83	HHEX	64,68	IGF2BP2	HHEX	10644	3087	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	IGF2BP2	70,77	HHEX	46,50	IGF2BP2	HHEX	10644	3087	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19008344	0	IGF2BP2	76,83	SLC30A8	55,62	IGF2BP2	SLC30A8	10644	169026	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	IGF2BP2	70,77	SLC30A8	37,44	IGF2BP2	SLC30A8	10644	169026	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|compound|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	IGF2BP2	70,77	TCF2	84,88	IGF2BP2	TCF2	10644	6928	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
25068994	0	IGF2BP3	55,62	IGF2_mRNA-binding_protein_3	26,53	IGF2BP3	IGF2 mRNA-binding protein 3	10643	10643	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the oncofetal IGF2_mRNA-binding_protein_3 -LRB- IGF2BP3 -RRB- in cancer .
24398995	0	IGF2R	55,60	COL6A3	68,74	IGF2R	COL6A3	395817(Tax:9031)	396548(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	IGF2R	55,60	EDNRB	76,81	IGF2R	EDNRB	395817(Tax:9031)	408082(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	IGF2R	55,60	KLF6	83,87	IGF2R	KLF6	395817(Tax:9031)	420463(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	IGF2R	55,60	RGS2	62,66	IGF2R	RGS2	395817(Tax:9031)	378912(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	IGF2R	55,60	folr1	48,53	IGF2R	folr1	395817(Tax:9031)	395638(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
22221028	0	IGF2R	100,105	insulin-like_growth_factor_2_receptor	56,93	IGF2R	insulin-like growth factor 2 receptor	281849(Tax:9913)	281849(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms in the imprinted bovine insulin-like_growth_factor_2_receptor gene -LRB- IGF2R -RRB- are associated with body size traits in Irish Holstein-Friesian cattle .
25068994	0	IGF2_mRNA-binding_protein_3	26,53	IGF2BP3	55,62	IGF2 mRNA-binding protein 3	IGF2BP3	10643	10643	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the oncofetal IGF2_mRNA-binding_protein_3 -LRB- IGF2BP3 -RRB- in cancer .
1283982	0	IGFBP-1	76,83	IGF-1	42,47	IGFBP-1	IGF-1	3484	3479	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	The role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- in the pathogenesis of polycystic_ovary_syndrome .
24148095	0	IGFBP-1	15,22	IGF-1	9,14	IGFBP-1	IGF-1	3484	3479	Gene	Gene	axis|compound|START_ENTITY associated|nsubjpass|axis END_ENTITY|parataxis|associated	Neonatal IGF-1 / IGFBP-1 axis and retinopathy_of_prematurity are associated with increased blood pressure in preterm children .
10088650	0	IGFBP-1	76,83	IGF-I	183,188	IGFBP-1	IGF-I	16006(Tax:10090)	16000(Tax:10090)	Gene	Gene	ameliorates|appos|START_ENTITY exacerbates|nsubj|ameliorates Insulin-like_growth_factor-I|acl:relcl|exacerbates Insulin-like_growth_factor-I|dep|studies studies|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- ameliorates and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- exacerbates the effects of undernutrition on brain growth during early postnatal life : studies in IGF-I and IGFBP-1 transgenic_mice .
10088650	0	IGFBP-1	76,83	IGF-I	30,35	IGFBP-1	IGF-I	16006(Tax:10090)	16000(Tax:10090)	Gene	Gene	ameliorates|appos|START_ENTITY exacerbates|nsubj|ameliorates Insulin-like_growth_factor-I|acl:relcl|exacerbates Insulin-like_growth_factor-I|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- ameliorates and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- exacerbates the effects of undernutrition on brain growth during early postnatal life : studies in IGF-I and IGFBP-1 transgenic_mice .
10350456	0	IGFBP-1	120,127	IGF-I	68,73	IGFBP-1	IGF-I	3484	3479	Gene	Gene	epitopes|nmod|START_ENTITY identifies|dobj|epitopes identifies|nsubj|mutagenesis mutagenesis|appos|END_ENTITY	Total alanine-scanning mutagenesis of insulin-like_growth_factor_I -LRB- IGF-I -RRB- identifies differential binding epitopes for IGFBP-1 and IGFBP-3 .
10990444	0	IGFBP-1	113,120	IGF-I	106,111	IGFBP-1	IGF-I	3484	3479	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Insulin-like growth factor I receptors on blood cells : their relationship to circulating total and `` free '' IGF-I , IGFBP-1 , IGFBP-3 and insulin levels in healthy subjects .
11579061	0	IGFBP-1	123,130	IGF-I	91,96	IGFBP-1	IGF-I	3484	3479	Gene	Gene	Effects|amod|START_ENTITY Effects|nmod|competition competition|nmod|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Effects of an endurance cycling competition on resting serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and its binding proteins IGFBP-1 and IGFBP-3 .
11928553	0	IGFBP-1	72,79	IGF-I	40,45	IGFBP-1	IGF-I	3484	3479	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	Function of insulin-like_growth_factor -LRB- IGF-I -RRB- and its binding protein -LRB- IGFBP-1 -RRB- in pathological proliferation of endometrium .
11994360	0	IGFBP-1	57,64	IGF-I	0,5	IGFBP-1	IGF-I	3484	3479	Gene	Gene	growth|amod|START_ENTITY phosphoisoforms|nmod|growth phosphoisoforms|nsubj|END_ENTITY	IGF-I , IGF_binding_protein _ -LRB- IGFBP -RRB- -3 , phosphoisoforms of IGFBP-1 , and postnatal growth in very low birth weight infants .
15302390	0	IGFBP-1	123,130	IGF-I	54,59	IGFBP-1	IGF-I	443132(Tax:9940)	443318(Tax:9940)	Gene	Gene	I|dep|START_ENTITY I|compound|END_ENTITY	Co-expression of messenger ribonucleic acids encoding IGF-I , IGF-II , type I and II IGF receptors and IGF-binding proteins -LRB- IGFBP-1 to -6 -RRB- during follicular development in the ovary of seasonally anoestrous ewes .
15713723	0	IGFBP-1	102,109	IGF-I	71,76	IGFBP-1	IGF-I	3484	3479	Gene	Gene	IGF_binding_protein_1|appos|START_ENTITY I|appos|IGF_binding_protein_1 I|appos|END_ENTITY	Testosterone and estradiol regulate free insulin-like growth factor I -LRB- IGF-I -RRB- , IGF_binding_protein_1 -LRB- IGFBP-1 -RRB- , and dimeric IGF-I/IGFBP -1 concentrations .
20155489	0	IGFBP-1	74,81	IGF-I	138,143	IGFBP-1	IGF-I	3484	3479	Gene	Gene	protein|appos|START_ENTITY factor-binding|dobj|protein factor-binding|advcl|serum serum|dobj|levels levels|amod|END_ENTITY	Common_genetic_variation_of_insulin-like_growth factor-binding protein 1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and acid labile subunit in relation to serum IGF-I levels and mammographic density .
20672288	0	IGFBP-1	64,71	IGF-I	85,90	IGFBP-1	IGF-I	3484	3479	Gene	Gene	potentiates|appos|START_ENTITY Polymerization|nmod|potentiates END_ENTITY|nsubj|Polymerization	Polymerization of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- potentiates IGF-I actions in placenta .
26380917	0	IGFBP-1	0,7	IGF-I	71,76	IGFBP-1	IGF-I	3484	3479	Gene	Gene	predicts|nsubj|START_ENTITY predicts|nmod|women women|nmod|END_ENTITY	IGFBP-1 predicts all-cause mortality in elderly women independently of IGF-I .
7472488	0	IGFBP-1	122,129	IGF-I	49,54	IGFBP-1	IGF-I	16006(Tax:10090)	16000(Tax:10090)	Gene	Gene	transgenic_mice|appos|START_ENTITY studies|nmod|transgenic_mice studies|nmod|actions actions|nmod|factor-I factor-I|appos|END_ENTITY	In vivo actions of insulin-like growth factor-I -LRB- IGF-I -RRB- on brain myelination : studies of IGF-I and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- transgenic_mice .
7472488	0	IGFBP-1	122,129	IGF-I	89,94	IGFBP-1	IGF-I	16006(Tax:10090)	16000(Tax:10090)	Gene	Gene	transgenic_mice|appos|START_ENTITY transgenic_mice|amod|END_ENTITY	In vivo actions of insulin-like growth factor-I -LRB- IGF-I -RRB- on brain myelination : studies of IGF-I and IGF_binding_protein-1 -LRB- IGFBP-1 -RRB- transgenic_mice .
7543116	0	IGFBP-1	155,162	IGF-I	140,145	IGFBP-1	IGF-I	3484	3479	Gene	Gene	index|dep|START_ENTITY index|amod|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
8784106	0	IGFBP-1	94,101	IGF-I	206,211	IGFBP-1	IGF-I	3484	3479	Gene	Gene	I|appos|START_ENTITY I|nmod|production production|dep|I I|appos|END_ENTITY	Insulin-like growth factor II -LRB- IGF-II -RRB- inhibits insulin-like growth factor binding protein I -LRB- IGFBP-1 -RRB- production in luteinized human granulosa cells with a potency similar to insulin-like growth factor I -LRB- IGF-I -RRB- and higher than insulin .
9497875	0	IGFBP-1	62,69	IGF-I	116,121	IGFBP-1	IGF-I	3484	3479	Gene	Gene	subunit|compound|START_ENTITY infusion|nmod|subunit infusion|appos|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9497875	0	IGFBP-1	62,69	IGF-I	41,46	IGFBP-1	IGF-I	3484	3479	Gene	Gene	subunit|compound|START_ENTITY infusion|nmod|subunit infusion|nmod|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9555872	0	IGFBP-1	149,156	IGF-I	119,124	IGFBP-1	IGF-I	3484	3479	Gene	Gene	IGF-binding_protein-1|appos|START_ENTITY axis|nsubj|IGF-binding_protein-1 change|parataxis|axis change|dep|association association|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Alcohol withdrawal-induced change in lipoprotein -LRB- a -RRB- : association with the growth_hormone / insulin-like_growth_factor-I -LRB- IGF-I -RRB- / IGF-binding_protein-1 -LRB- IGFBP-1 -RRB- axis .
11228264	0	IGFBP-1	32,39	IGF-II	0,6	IGFBP-1	IGF-II	696994(Tax:9544)	3481	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	IGF-II and IGF binding protein -LRB- IGFBP-1 , IGFBP-3 -RRB- gene expression in fetal rhesus_monkey tissues during the second and third trimesters .
15302390	0	IGFBP-1	123,130	IGF-II	61,67	IGFBP-1	IGF-II	443132(Tax:9940)	443325(Tax:9940)	Gene	Gene	I|dep|START_ENTITY I|dep|END_ENTITY	Co-expression of messenger ribonucleic acids encoding IGF-I , IGF-II , type I and II IGF receptors and IGF-binding proteins -LRB- IGFBP-1 to -6 -RRB- during follicular development in the ovary of seasonally anoestrous ewes .
19199270	0	IGFBP-1	24,31	IGF-II	47,53	IGFBP-1	IGF-II	3484	3481	Gene	Gene	START_ENTITY|nmod|concentration concentration|amod|END_ENTITY	Association of elevated IGFBP-1 with increased IGF-II concentration in patients with carcinoma_of_the_liver .
7543116	0	IGFBP-1	155,162	IGF-II	147,153	IGFBP-1	IGF-II	3484	3481	Gene	Gene	index|dep|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
8784106	0	IGFBP-1	94,101	IGF-II	31,37	IGFBP-1	IGF-II	3484	3481	Gene	Gene	I|appos|START_ENTITY factor|dobj|I inhibits|ccomp|factor inhibits|nsubj|II II|appos|END_ENTITY	Insulin-like growth factor II -LRB- IGF-II -RRB- inhibits insulin-like growth factor binding protein I -LRB- IGFBP-1 -RRB- production in luteinized human granulosa cells with a potency similar to insulin-like growth factor I -LRB- IGF-I -RRB- and higher than insulin .
11147791	0	IGFBP-1	103,110	IGFBP-1	75,82	IGFBP-1	IGFBP-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Physiological differences in insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation in IGFBP-1 transgenic_mice .
11147791	0	IGFBP-1	75,82	IGFBP-1	103,110	IGFBP-1	IGFBP-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Physiological differences in insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation in IGFBP-1 transgenic_mice .
7543116	0	IGFBP-1	155,162	IGFBP-2	164,171	IGFBP-1	IGFBP-2	3484	3485	Gene	Gene	index|dep|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
9714057	0	IGFBP-1	100,107	IGFBP-2	0,7	IGFBP-1	IGFBP-2	3484	3485	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|compound|END_ENTITY	IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis , decreased IGFBP-1 expression and increased tumorigenicity .
20155489	0	IGFBP-1	74,81	IGFBP-3	84,91	IGFBP-1	IGFBP-3	3484	3486	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Common_genetic_variation_of_insulin-like_growth factor-binding protein 1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and acid labile subunit in relation to serum IGF-I levels and mammographic density .
7543116	0	IGFBP-1	155,162	IGFBP-3	68,75	IGFBP-1	IGFBP-3	3484	3486	Gene	Gene	index|dep|START_ENTITY relation|nmod|index levels|dep|relation levels|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
9497875	0	IGFBP-1	62,69	IGFBP-3	71,78	IGFBP-1	IGFBP-3	3484	3486	Gene	Gene	subunit|compound|START_ENTITY subunit|dep|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9714057	0	IGFBP-1	100,107	IGFBP-3	69,76	IGFBP-1	IGFBP-3	3484	3486	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis , decreased IGFBP-1 expression and increased tumorigenicity .
18031314	0	IGFBP-1	22,29	Insulin	0,7	IGFBP-1	Insulin	3484	3630	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Insulin , adiponectin , IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages .
1280613	0	IGFBP-1	46,53	Insulin-like_growth_factor_binding_protein_1	0,44	IGFBP-1	Insulin-like growth factor binding protein 1	3484	3484	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Insulin-like_growth_factor_binding_protein_1 -LRB- IGFBP-1 -RRB- levels in Turner_syndrome .
9178756	0	IGFBP-1	96,103	Progesterone_receptor	0,21	IGFBP-1	Progesterone receptor	3484	5241	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Progesterone_receptor -LRB- PR -RRB- inhibits expression of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- in human endometrial cell line HEC-1B : characterization of the inhibitory effect of PR on the distal promoter region of the IGFBP-1 gene .
18031314	0	IGFBP-1	22,29	adiponectin	9,20	IGFBP-1	adiponectin	3484	9370	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	Insulin , adiponectin , IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages .
11117526	0	IGFBP-1	115,122	hPR-B	87,92	IGFBP-1	hPR-B	3484	5925	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Ligand-activated progesterone_receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 -LRB- insulin-like_growth_factor_binding_protein-1 -RRB- in human endometrial stromal cells .
9707622	0	IGFBP-1	127,134	hypoxia	155,162	IGFBP-1	IGFBP-1	3484	3484	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Hypoxia stimulates insulin-like_growth_factor_binding_protein_1 -LRB- IGFBP-1 -RRB- gene expression in HepG2 cells : a possible model for IGFBP-1 expression in fetal hypoxia .
14568572	0	IGFBP-1	87,94	insulin	150,157	IGFBP-1	insulin	3484	3630	Gene	Gene	insulin-like_growth_factor-binding_protein-1|appos|START_ENTITY regulation|nmod|insulin-like_growth_factor-binding_protein-1 studies|nmod|regulation studies|nmod|factors factors|compound|END_ENTITY	Comparative studies on the regulation of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- and sex_hormone-binding_globulin -LRB- SHBG -RRB- production by insulin and insulin-like growth factors in human hepatoma cells .
24056811	0	IGFBP-1	54,61	insulin	84,91	IGFBP-1	insulin	3484	3630	Gene	Gene	Delta|appos|START_ENTITY Delta|dep|marker marker|nmod|resistance resistance|compound|END_ENTITY	Delta insulin-like_growth_factor_binding_protein-1 -LRB- / \ IGFBP-1 -RRB- : a marker of hepatic insulin resistance ?
7521354	0	IGFBP-1	93,100	insulin	10,17	IGFBP-1	insulin	3484	3630	Gene	Gene	insulin-like_growth_factor-binding_protein-1|dep|START_ENTITY production|acl|insulin-like_growth_factor-binding_protein-1 Effect|nmod|production Effect|nmod|END_ENTITY	Effect of insulin on the hepatic production of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and IGF-I in insulin-dependent diabetes .
8636256	0	IGFBP-1	129,136	insulin	47,54	IGFBP-1	insulin	3484	3630	Gene	Gene	production|appos|START_ENTITY _|nmod|production mediates|nmod|_ mediates|dobj|effect effect|nmod|END_ENTITY	Insulin_receptor mediates inhibitory effect of insulin , but not of insulin-like_growth_factor _ -LRB- IGF -RRB- - I , on IGF_binding_protein_1 -LRB- IGFBP-1 -RRB- production in human granulosa cells .
9542973	0	IGFBP-1	60,67	insulin-like_growth_factor-binding_protein-1	14,58	IGFBP-1	insulin-like growth factor-binding protein-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA in embryos and endometrial stromal cells .
10226804	0	IGFBP-1	132,139	insulin-like_growth_factor_binding_protein-1	86,130	IGFBP-1	insulin-like growth factor binding protein-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Interleukin-1_alpha -LRB- IL-1_alpha -RRB- and tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- regulate insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- levels and mRNA abundance in vivo and in vitro .
10425467	0	IGFBP-1	60,67	insulin-like_growth_factor_binding_protein-1	14,58	IGFBP-1	insulin-like growth factor binding protein-1	3484	3484	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA in the ovine uterus throughout the oestrous cycle and early pregnancy .
11044255	0	IGFBP-1	67,74	insulin-like_growth_factor_binding_protein-1	21,65	IGFBP-1	insulin-like growth factor binding protein-1	25685(Tax:10116)	25685(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of hepatic insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- in rats by dietary n-6_polyunsaturated_fatty_acids .
11147791	0	IGFBP-1	103,110	insulin-like_growth_factor_binding_protein-1	29,73	IGFBP-1	insulin-like growth factor binding protein-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Physiological differences in insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation in IGFBP-1 transgenic_mice .
11147791	0	IGFBP-1	75,82	insulin-like_growth_factor_binding_protein-1	29,73	IGFBP-1	insulin-like growth factor binding protein-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Physiological differences in insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation in IGFBP-1 transgenic_mice .
15200677	0	IGFBP-1	113,120	insulin-like_growth_factor_binding_protein-1	67,111	IGFBP-1	insulin-like growth factor binding protein-1	101026642	101026642	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Uterine receptivity and implantation : the regulation and action of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- , HOXA10 and forkhead transcription factor-1 -LRB- FOXO-1 -RRB- in the baboon endometrium .
1696886	0	IGFBP-1	78,85	insulin-like_growth_factor_binding_protein-1	32,76	IGFBP-1	insulin-like growth factor binding protein-1	25685(Tax:10116)	25685(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Dexamethasone increases hepatic insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA and serum IGFBP-1 concentrations in the rat .
1713220	0	IGFBP-1	68,75	insulin-like_growth_factor_binding_protein-1	22,66	IGFBP-1	insulin-like growth factor binding protein-1	3484	3484	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Octreotide stimulates insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- levels in acromegaly .
18598121	0	IGFBP-1	90,97	insulin-like_growth_factor_binding_protein-1	44,88	IGFBP-1	insulin-like growth factor binding protein-1	3484	3484	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Evidence supporting proteolytic cleavage of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- protein in amniotic_fluid .
19732896	0	IGFBP-1	52,59	insulin-like_growth_factor_binding_protein-1	6,50	IGFBP-1	insulin-like growth factor binding protein-1	3484	3484	Gene	Gene	status|compound|START_ENTITY status|amod|END_ENTITY	Serum insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation status in subjects with and without ischaemic_heart_disease .
7534144	0	IGFBP-1	60,67	insulin-like_growth_factor_binding_protein-1	14,58	IGFBP-1	insulin-like growth factor binding protein-1	3484	3484	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- in insulin-dependent_diabetes_mellitus .
7683312	0	IGFBP-1	113,120	insulin-like_growth_factor_binding_protein-1	67,111	IGFBP-1	insulin-like growth factor binding protein-1	25685(Tax:10116)	25685(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Interactive effects of nutrients and hormones on the expression of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA and peptide , and IGF_I release from isolated adult rat hepatocytes .
16448523	0	IGFBP-1	59,66	proinsulin	20,30	IGFBP-1	proinsulin	3484	3630	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	The serum levels of proinsulin and their relationship with IGFBP-1 in obese children .
25787077	0	IGFBP-2	123,130	IGF-I	66,71	IGFBP-2	IGF-I	16008(Tax:10090)	16000(Tax:10090)	Gene	Gene	Insulin-Like_Growth_Factor-I|appos|START_ENTITY Insulin-Like_Growth_Factor-I|appos|END_ENTITY	The Coordinate Cellular Response to Insulin-Like_Growth_Factor-I -LRB- IGF-I -RRB- and Insulin-Like_Growth_Factor_Binding_Protein-2 -LRB- IGFBP-2 -RRB- Is Regulated Through Vimentin Binding to Receptor_Tyrosine_Phosphatase_b -LRB- RPTPb -RRB- .
7543116	0	IGFBP-2	164,171	IGF-I	140,145	IGFBP-2	IGF-I	3485	3479	Gene	Gene	index|dep|START_ENTITY index|amod|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
7543116	0	IGFBP-2	164,171	IGF-II	147,153	IGFBP-2	IGF-II	3485	3481	Gene	Gene	index|dep|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
7543116	0	IGFBP-2	164,171	IGFBP-1	155,162	IGFBP-2	IGFBP-1	3485	3484	Gene	Gene	index|dep|START_ENTITY index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
9714057	0	IGFBP-2	0,7	IGFBP-1	100,107	IGFBP-2	IGFBP-1	3485	3484	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|compound|END_ENTITY	IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis , decreased IGFBP-1 expression and increased tumorigenicity .
7543116	0	IGFBP-2	164,171	IGFBP-3	68,75	IGFBP-2	IGFBP-3	3485	3486	Gene	Gene	index|dep|START_ENTITY relation|nmod|index levels|dep|relation levels|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
9714057	0	IGFBP-2	0,7	IGFBP-3	69,76	IGFBP-2	IGFBP-3	3485	3486	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|compound|END_ENTITY	IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis , decreased IGFBP-1 expression and increased tumorigenicity .
14617774	0	IGFBP-2	56,63	IIp45	0,5	IGFBP-2	IIp45	3485	60672	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|appos|protein	IIp45 , an insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- binding protein , antagonizes IGFBP-2 stimulation of glioma_cell_invasion .
21750048	0	IGFBP-2	0,7	VEGF	17,21	IGFBP-2	VEGF	3485	7422	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells .
10372962	0	IGFBP-2	97,104	insulin-like_growth_factor_binding_protein-2	51,95	IGFBP-2	insulin-like growth factor binding protein-2	25662(Tax:10116)	25662(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cell-density -LRB- cycle -RRB- dependent silencer of the rat insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- gene .
8624265	0	IGFBP-2	56,63	insulin-like_growth_factor_binding_protein-2	10,54	IGFBP-2	insulin-like growth factor binding protein-2	3485	3485	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Increased insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- gene expression and protein production lead to high IGFBP-2 content in malignant ovarian_cyst fluid .
8817676	0	IGFBP-2	75,82	insulin-like_growth_factor_binding_protein-2	29,73	IGFBP-2	insulin-like growth factor binding protein-2	25662(Tax:10116)	25662(Tax:10116)	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Cell membrane association of insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- in the rat brain olfactory bulb .
9741833	0	IGFBP-2	80,87	insulin-like_growth_factor_binding_protein-2	34,78	IGFBP-2	insulin-like growth factor binding protein-2	3485	3485	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A distal regulatory region of the insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- gene interacts with the basic helix-loop-helix transcription factor , AP-4 .
14617774	0	IGFBP-2	56,63	insulin-like_growth_factor_binding_protein_2	10,54	IGFBP-2	insulin-like growth factor binding protein 2	3485	3485	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	IIp45 , an insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- binding protein , antagonizes IGFBP-2 stimulation of glioma_cell_invasion .
7526357	0	IGFBP-2	60,67	insulin-like_growth_factor_binding_protein_2	14,58	IGFBP-2	insulin-like growth factor binding protein 2	3485	3485	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- in Wilms ' _ tumors .
23557743	0	IGFBP-3	26,33	DNA-PK	0,6	IGFBP-3	DNA-PK	3486	5591	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	DNA-PK phosphorylation of IGFBP-3 is required to prevent apoptosis in retinal endothelial cells cultured in high glucose .
9657073	0	IGFBP-3	73,80	GH	14,16	IGFBP-3	GH	3486	2688	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|therapy therapy|compound|END_ENTITY	The effect of GH therapy on the immunoreactive forms and distribution of IGFBP-3 , IGF-I , the acid-labile_subunit , and growth rate in GH-deficient children .
22751133	0	IGFBP-3	0,7	GRP78	14,19	IGFBP-3	GRP78	3486	3309	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	IGFBP-3 binds GRP78 , stimulates autophagy and promotes the survival of breast_cancer cells exposed to adverse microenvironments .
8674850	0	IGFBP-3	49,56	Growth_hormone	0,14	IGFBP-3	Growth hormone	24484(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- regulate IGFBP-3 gene expression in rat beta-cells .
10235530	0	IGFBP-3	62,69	IGF-1	56,61	IGFBP-3	IGF-1	3486	3479	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Muscle protein catabolism after severe burn : effects of IGF-1 / IGFBP-3 treatment .
10932487	0	IGFBP-3	111,118	IGF-1	54,59	IGFBP-3	IGF-1	3486	3479	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	The usefulness of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- for evaluation of children with short_stature .
11524173	0	IGFBP-3	39,46	IGF-1	32,37	IGFBP-3	IGF-1	3486	3479	Gene	Gene	mediates|compound|START_ENTITY increase|dep|mediates increase|nmod|END_ENTITY	A local increase in the mammary IGF-1 : IGFBP-3 ratio mediates the mammogenic effects of estrogen and growth_hormone .
15775992	0	IGFBP-3	87,94	IGF-1	53,58	IGFBP-3	IGF-1	3486	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|insulin-like_growth_factor-1 insulin-like_growth_factor-1|dep|END_ENTITY	Putative role of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels in the development of prostate_cancer in Arab men .
17627262	0	IGFBP-3	13,20	IGF-1	6,11	IGFBP-3	IGF-1	3486	3479	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Serum IGF-1 , IGFBP-3 and growth_hormone levels in children with congenital_heart_disease : relationship with nutritional status , cyanosis and left ventricular functions .
17673197	0	IGFBP-3	99,106	IGF-1	65,70	IGFBP-3	IGF-1	3486	3479	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	Reference values for serum levels of insulin-like_growth_factor -LRB- IGF-1 -RRB- and IGF-binding_protein_3 -LRB- IGFBP-3 -RRB- and their ratio in Chinese adolescents .
18093232	0	IGFBP-3	7,14	IGF-1	0,5	IGFBP-3	IGF-1	3486	3479	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	IGF-1 , IGFBP-3 , VEGF and MMP-9 levels and their potential relationship with renal functions in patients with compensatory renal growth .
19944347	0	IGFBP-3	93,100	IGF-1	59,64	IGFBP-3	IGF-1	3486	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|insulin-like_growth_factor_1 insulin-like_growth_factor_1|dep|END_ENTITY	Anthropometric correlates of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels by race/ethnicity and gender .
20567839	0	IGFBP-3	21,28	IGF-1	15,20	IGFBP-3	IGF-1	3486	3479	Gene	Gene	signaling|nsubj|START_ENTITY Involvement|parataxis|signaling Involvement|nmod|END_ENTITY	Involvement of IGF-1 / IGFBP-3 signaling on the conspicuousness of facial pores .
21865482	0	IGFBP-3	102,109	IGF-1	96,101	IGFBP-3	IGF-1	3486	3479	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|/ /|amod|END_ENTITY	Serum concentrations of insulin-like_growth_factor _ -LRB- IGF -RRB- -1 and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-1 / IGFBP-3 ratio , and markers of bone turnover : reference values for French children and adolescents and z-score comparability with other references .
21898383	0	IGFBP-3	50,57	IGF-1	34,39	IGFBP-3	IGF-1	3486	3479	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio Increase|parataxis|associated Increase|acl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Increase in circulating levels of IGF-1 and IGF-1 / IGFBP-3 molar ratio over a decade is associated with colorectal_adenomatous_polyps .
22180012	0	IGFBP-3	126,133	IGF-1	92,97	IGFBP-3	IGF-1	448812(Tax:9823)	101055342	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Effects of copper on proliferation and autocrine secretion of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- in chondrocytes from newborn pigs in vitro .
22709450	0	IGFBP-3	61,68	IGF-1	30,35	IGFBP-3	IGF-1	3486	3479	Gene	Gene	IGF-binding_protein-3|appos|START_ENTITY END_ENTITY|appos|IGF-binding_protein-3	Insulin-like_growth_factor-I -LRB- IGF-1 -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- and mammographic features .
22740980	0	IGFBP-3	6,13	IGF-1	49,54	IGFBP-3	IGF-1	3486	3479	Gene	Gene	predictor|nsubj|START_ENTITY predictor|nmod|END_ENTITY	Serum IGFBP-3 is a more effective predictor than IGF-1 and IGF-2 for the development of hepatocellular_carcinoma in patients with chronic HCV_infection .
23327101	0	IGFBP-3	101,108	IGF-1	67,72	IGFBP-3	IGF-1	100539598	678666(Tax:9103)	Gene	Gene	insulin-like_growth_factor_1|appos|START_ENTITY insulin-like_growth_factor_1|appos|END_ENTITY	Reference values for serum levels of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and IGF-binding_protein_3 -LRB- IGFBP-3 -RRB- in the West Black Sea region of Turkey .
24254307	0	IGFBP-3	117,124	IGF-1	61,66	IGFBP-3	IGF-1	3486	3479	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Clinical significance of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and insulinlike_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in patients with epithelial_ovarian_cancer .
24424057	0	IGFBP-3	145,152	IGF-1	29,34	IGFBP-3	IGF-1	16009(Tax:10090)	16000(Tax:10090)	Gene	Gene	complexes|compound|START_ENTITY Quantification|dep|complexes Quantification|nmod|binding binding|nmod|END_ENTITY	Quantification of binding of IGF-1 to BI_836845 , a candidate therapeutic antibody against IGF-1 and IGF-2 , and effects of this antibody on IGF-1 : IGFBP-3 complexes in vitro and in male C57BL/6 mice .
24633053	0	IGFBP-3	78,85	IGF-1	33,38	IGFBP-3	IGF-1	24484(Tax:10116)	24482(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY altering|dobj|binding regulates|advcl|altering regulates|dobj|homeostasis homeostasis|compound|END_ENTITY	Cyclic_glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1 .
24633053	0	IGFBP-3	78,85	IGF-1	89,94	IGFBP-3	IGF-1	24484(Tax:10116)	24482(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY altering|dobj|binding altering|nmod|END_ENTITY	Cyclic_glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1 .
24943688	0	IGFBP-3	118,125	IGF-1	61,66	IGFBP-3	IGF-1	3486	3479	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Clinical significance of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in patients with breast_cancer .
26388613	0	IGFBP-3	48,55	IGF-1	22,27	IGFBP-3	IGF-1	3486	3479	Gene	Gene	ratio|amod|START_ENTITY levels|dep|ratio levels|nmod|END_ENTITY	Circulating levels of IGF-1 , IGFBP-3 , and IGF-1 / IGFBP-3 molar ratio and colorectal_adenomas : A meta-analysis .
26388613	0	IGFBP-3	48,55	IGF-1	22,27	IGFBP-3	IGF-1	3486	3479	Gene	Gene	ratio|amod|START_ENTITY levels|dep|ratio levels|nmod|END_ENTITY	Circulating levels of IGF-1 , IGFBP-3 , and IGF-1 / IGFBP-3 molar ratio and colorectal_adenomas : A meta-analysis .
26402757	0	IGFBP-3	22,29	IGF-1	16,21	IGFBP-3	IGF-1	3486	3479	Gene	Gene	Ratio|compound|START_ENTITY Associated|nsubj|Ratio END_ENTITY|parataxis|Associated	Decreased Serum IGF-1 / IGFBP-3 Molar Ratio is Associated with Executive Function Behaviors in Type 2 Diabetic Patients with Mild Cognitive_Impairment .
26445161	0	IGFBP-3	22,29	IGF-1	16,21	IGFBP-3	IGF-1	3486	3479	Gene	Gene	Ratio|compound|START_ENTITY Associated|nsubj|Ratio END_ENTITY|parataxis|Associated	Decreased Serum IGF-1 / IGFBP-3 Molar Ratio is Associated with Executive Function Behaviors in Type 2 Diabetic Patients with Mild Cognitive_Impairment .
7688379	0	IGFBP-3	206,213	IGF-1	172,177	IGFBP-3	IGF-1	3486	3479	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY insulin-like_growth_factor-1|appos|END_ENTITY	Supplementary growth_hormone treatment of women with poor ovarian response to exogenous gonadotrophins : changes in serum and follicular fluid insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- .
8701035	0	IGFBP-3	124,131	IGF-1	135,140	IGFBP-3	IGF-1	3486	3479	Gene	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Developmentally regulated expression of IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- in human placental fibroblasts : effect of exogenous IGFBP-3 on IGF-1 action .
8701035	0	IGFBP-3	63,70	IGF-1	135,140	IGFBP-3	IGF-1	3486	3479	Gene	Gene	IGF_binding_protein-3|appos|START_ENTITY expression|nmod|IGF_binding_protein-3 expression|dep|effect effect|nmod|IGFBP-3 IGFBP-3|nmod|action action|compound|END_ENTITY	Developmentally regulated expression of IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- in human placental fibroblasts : effect of exogenous IGFBP-3 on IGF-1 action .
10668288	0	IGFBP-3	98,105	IGF-I	62,67	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	-LSB- Usefulness of the measurement of insulin-like_growth_factor -LRB- IGF-I -RRB- and IGF-1_binding_protein-3 -LRB- IGFBP-3 -RRB- for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in children -RSB- .
10700718	0	IGFBP-3	61,68	IGF-I	31,36	IGFBP-3	IGF-I	3486	3479	Gene	Gene	efficiency|appos|START_ENTITY efficiency|nmod|serum serum|nummod|END_ENTITY	Diagnostic efficiency of serum IGF-I , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and urinary GH measurements in the diagnosis of adult_GH_deficiency : importance of an appropriate reference population .
10703534	0	IGFBP-3	64,71	IGF-I	30,35	IGFBP-3	IGF-I	3486	3479	Gene	Gene	Insulin-like_growth_factor-I|dep|START_ENTITY Insulin-like_growth_factor-I|dep|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- concentrations compared to stimulated growth_hormone -LRB- GH -RRB- in the evaluation of children treated for malignancy .
10856880	0	IGFBP-3	46,53	IGF-I	70,75	IGFBP-3	IGF-I	3486	3479	Gene	Gene	effects|amod|START_ENTITY effects|nmod|action action|amod|END_ENTITY	Differential effects of IGF-binding proteins , IGFBP-3 and IGFBP-5 , on IGF-I action and binding to cell membranes of immortalized human chondrocytes .
10971450	0	IGFBP-3	78,85	IGF-I	47,52	IGFBP-3	IGF-I	3486	3479	Gene	Gene	IGF_binding_protein-3|appos|START_ENTITY insulin-like_growth_factor-I|appos|IGF_binding_protein-3 insulin-like_growth_factor-I|appos|END_ENTITY	Monitoring serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and leptin during growth hormone treatment for disordered growth .
11592569	0	IGFBP-3	85,92	IGF-I	55,60	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Maternal and fetal serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , leptin levels and early postnatal growth in infants born asymmetrically small for gestational age .
14674122	0	IGFBP-3	63,70	IGF-I	90,95	IGFBP-3	IGF-I	3486	3479	Gene	Gene	secretion|nmod|START_ENTITY impact|nmod|secretion impact|parataxis|depends depends|nsubj|-RSB- -RSB-|amod|END_ENTITY	The impact of progesterone on simultaneous , local secretion of IGFBP-3 and IGF-I -LSB- IGFBP-3 / IGF-I index -RSB- by human malignant and non-malignant breast explants depends on tissue steroid receptor phenotype .
14974910	0	IGFBP-3	18,25	IGF-I	10,15	IGFBP-3	IGF-I	3486	3479	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Increased IGF-I : IGFBP-3 ratio in patients with hepatocellular_carcinoma .
15126555	0	IGFBP-3	128,135	IGF-I	97,102	IGFBP-3	IGF-I	3486	3479	Gene	Gene	IGF-binding_protein-3|appos|START_ENTITY insulin-like_growth_factor_I|appos|IGF-binding_protein-3 insulin-like_growth_factor_I|appos|END_ENTITY	Sustained elevation of pulsatile growth_hormone -LRB- GH -RRB- secretion and insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women .
15259383	0	IGFBP-3	133,140	IGF-I	99,104	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Reference ranges for two automated chemiluminescent assays for serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein_3 -LRB- IGFBP-3 -RRB- .
15270408	0	IGFBP-3	89,96	IGF-I	82,87	IGFBP-3	IGF-I	3486	3479	Gene	Gene	ALS|compound|START_ENTITY END_ENTITY|dep|ALS	Alterations in serum growth_hormone -LRB- GH -RRB- / GH dependent ternary complex components -LRB- IGF-I , IGFBP-3 , ALS , IGF-I/IGFBP -3 molar ratio -RRB- and the influence of these alterations on growth pattern in female rhythmic gymnasts .
15342444	0	IGFBP-3	107,114	IGF-I	73,78	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Dietary and lifestyle correlates of plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- : the multiethnic cohort .
15641262	0	IGFBP-3	109,116	IGF-I	75,80	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Influence of iodine supplementation on serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- levels in severe_iodine_deficiency .
16210470	0	IGFBP-3	27,34	IGF-I	89,94	IGFBP-3	IGF-I	3486	3479	Gene	Gene	regulation|nmod|START_ENTITY determines|nsubj|regulation determines|dobj|response response|nmod|END_ENTITY	EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I .
17044083	0	IGFBP-3	116,123	IGF-I	39,44	IGFBP-3	IGF-I	3486	3479	Gene	Gene	interaction|appos|START_ENTITY dependent|nmod|interaction dependent|nsubj|association association|amod|insulin-like_growth_factor-I insulin-like_growth_factor-I|dep|END_ENTITY	Enhanced insulin-like_growth_factor-I -LRB- IGF-I -RRB- cell association at reduced pH is dependent on IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- interaction .
17113804	0	IGFBP-3	66,73	IGF-I	36,41	IGFBP-3	IGF-I	3486	3479	Gene	Gene	IGF_binding_protein-3|appos|START_ENTITY IGF_binding_protein-3|appos|END_ENTITY	Serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- and leptin levels are related to abdominal aortic intima-media thickness in macrosomic newborns .
1720092	0	IGFBP-3	160,167	IGF-I	108,113	IGFBP-3	IGF-I	3486	104978413	Gene	Gene	processing|nmod|START_ENTITY evidence|nmod|processing potentiation|dep|evidence potentiation|nmod|action action|amod|END_ENTITY	Glycosylation of insulin-like growth factor binding protein-3 -LRB- IGFBP-3 -RRB- is not required for potentiation of IGF-I action : evidence for processing of cell-bound IGFBP-3 .
1720092	0	IGFBP-3	63,70	IGF-I	108,113	IGFBP-3	IGF-I	3486	104978413	Gene	Gene	factor|appos|START_ENTITY Glycosylation|nmod|factor required|nsubjpass|Glycosylation required|nmod|potentiation potentiation|nmod|action action|amod|END_ENTITY	Glycosylation of insulin-like growth factor binding protein-3 -LRB- IGFBP-3 -RRB- is not required for potentiation of IGF-I action : evidence for processing of cell-bound IGFBP-3 .
17395977	0	IGFBP-3	40,47	IGF-I	6,11	IGFBP-3	IGF-I	3486	3479	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|appos|protein	Serum IGF-I , its major binding protein -LRB- IGFBP-3 -RRB- and epithelial_ovarian_cancer risk : the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- .
17984239	2	IGFBP-3	636,643	IGF-I	629,634	IGFBP-3	IGF-I	3486	3479	Gene	Gene	assays|appos|START_ENTITY assays|amod|END_ENTITY	OBJECTIVE : We evaluated the agreement between different IGF-I -LRB- IGFBP-3 -RRB- assays in predicting GH_deficiency and tested whether variability between growth factor screening and pharmacological testing could be diminished by reassessment of growth factor and GH peak concentrations in a single laboratory .
20155489	0	IGFBP-3	84,91	IGF-I	138,143	IGFBP-3	IGF-I	3486	3479	Gene	Gene	protein|appos|START_ENTITY factor-binding|dobj|protein factor-binding|advcl|serum serum|dobj|levels levels|amod|END_ENTITY	Common_genetic_variation_of_insulin-like_growth factor-binding protein 1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and acid labile subunit in relation to serum IGF-I levels and mammographic density .
20553076	0	IGFBP-3	68,75	IGF-I	53,58	IGFBP-3	IGF-I	3486	3479	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Associations of food and nutrient intakes with serum IGF-I , IGF-II , IGFBP-3 , TGF-b1 , total SOD activity and sFas levels among middle-aged Japanese : the Japan Collaborative Cohort study .
20553077	0	IGFBP-3	117,124	IGF-I	83,88	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Time spent walking or exercising and blood levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- : A large-scale cross-sectional study in the Japan Collaborative Cohort study .
21536469	0	IGFBP-3	68,75	IGF-I	186,191	IGFBP-3	IGF-I	3486	3479	Gene	Gene	protein-3|dep|START_ENTITY polymorphism|amod|protein-3 binding|dobj|polymorphism binding|nmod|levels levels|nmod|END_ENTITY	Relationship_of_insulin-like_growth factor -LRB- IGF -RRB- binding protein-3 -LRB- IGFBP-3 -RRB- gene polymorphism with the susceptibility to development of prostate_cancer and influence on serum levels of IGF-I , and IGFBP-3 .
21670726	0	IGFBP-3	52,59	IGF-I	45,50	IGFBP-3	IGF-I	3486	3479	Gene	Gene	IGFBP-2|dep|START_ENTITY IGFBP-2|dep|END_ENTITY	Overexpression of P53 protein and local hGH , IGF-I , IGFBP-3 , IGFBP-2 and PRL secretion by human breast_cancer explants .
22776750	0	IGFBP-3	50,57	IGF-I	35,40	IGFBP-3	IGF-I	3486	3479	Gene	Gene	AMH|appos|START_ENTITY AMH|compound|END_ENTITY	Follicular fluid concentrations of IGF-I , IGF-II , IGFBP-3 , VEGF , AMH , and inhibin-B in women undergoing controlled ovarian_hyperstimulation using GnRH agonist or GnRH antagonist .
23174226	0	IGFBP-3	67,74	IGF-I	129,134	IGFBP-3	IGF-I	3486	3479	Gene	Gene	gene|compound|START_ENTITY gene|nmod|risk risk|nmod|END_ENTITY	The influence of promoter -202 _ A/C polymorphism -LRB- rs2854744 -RRB- of the IGFBP-3 gene on erectile_dysfunction risk and serum levels of IGF-I and IGFBP-3 .
23473966	0	IGFBP-3	108,115	IGF-I	74,79	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Serum but not cerebrospinal fluid levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- are increased in Alzheimer 's _ disease .
25817945	0	IGFBP-3	52,59	IGF-I	17,22	IGFBP-3	IGF-I	3486	3479	Gene	Gene	proteolysis|compound|START_ENTITY changes|nmod|proteolysis Association|nmod|changes END_ENTITY|dep|Association	Free dissociable IGF-I : Association with changes in IGFBP-3 proteolysis and insulin sensitivity after surgery .
7505289	0	IGFBP-3	193,200	IGF-I	176,181	IGFBP-3	IGF-I	3486	3479	Gene	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	The composition and distribution of insulin-like growth factors -LRB- IGFs -RRB- and IGF-binding proteins -LRB- IGFBPs -RRB- in the serum of growth_hormone_receptor-deficient patients : effects of IGF-I therapy on IGFBP-3 .
7523204	0	IGFBP-3	14,21	IGF-I	59,64	IGFBP-3	IGF-I	3486	3479	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|actions actions|nmod|END_ENTITY	IGF-I-induced IGFBP-3 potentiates the mitogenic actions of IGF-I in mammary epithelial MD-IGF-I cells .
7524925	0	IGFBP-3	83,90	IGF-I	49,54	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7543116	0	IGFBP-3	68,75	IGF-I	140,145	IGFBP-3	IGF-I	3486	3479	Gene	Gene	levels|dep|START_ENTITY levels|dep|relation relation|nmod|index index|amod|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
7546777	0	IGFBP-3	47,54	IGF-I	30,35	IGFBP-3	IGF-I	3486	3479	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|Insulin-like_growth_factor-I Insulin-like_growth_factor-I|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- regulates IGFBP-3 and IGFBP-4 by multiple mechanisms in A549 human adenocarcinoma cells .
7696822	0	IGFBP-3	68,75	IGF-I	111,116	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor_binding_protein_3|appos|START_ENTITY insulin-like_growth_factor_binding_protein_3|appos|END_ENTITY	Circulating levels of insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- and insulin-like_growth_factor_I -LRB- IGF-I -RRB- in perimenopausal women .
8612547	0	IGFBP-3	67,74	IGF-I	199,204	IGFBP-3	IGF-I	24484(Tax:10116)	24482(Tax:10116)	Gene	Gene	_|dep|START_ENTITY Proteolysis|nmod|_ promotes|nsubj|Proteolysis promotes|dobj|release release|nmod|END_ENTITY	Proteolysis of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in 150-kilodalton IGFBP complexes by a cation-dependent protease activity in adult rat serum promotes the release of bound IGF-I .
8674839	0	IGFBP-3	141,148	IGF-I	84,89	IGFBP-3	IGF-I	24484(Tax:10116)	24482(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Estradiol and triiodothyronine increase production of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- by GH4C1 rat pituitary_tumor cells .
8717444	0	IGFBP-3	26,33	IGF-I	61,66	IGFBP-3	IGF-I	3486	3479	Gene	Gene	synthesis|amod|START_ENTITY Regulation|nmod|synthesis Regulation|nmod|END_ENTITY	Regulation of endothelial IGFBP-3 synthesis and secretion by IGF-I and TGF-beta .
9160813	0	IGFBP-3	85,92	IGF-I	51,56	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Comparative study of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- level and IGF-I/IGFBP -3 ratio measurements and their relationship with an index of clinical activity in the management of patients with acromegaly .
9387030	0	IGFBP-3	90,97	IGF-I	45,50	IGFBP-3	IGF-I	3486	3479	Gene	Gene	and_their_binding_protein|appos|START_ENTITY elevated|nsubj|and_their_binding_protein _|ccomp|elevated _|nsubj|levels levels|appos|END_ENTITY	Serum levels of insulin-like growth factors -LRB- IGF-I and IGF-II -RRB- _ and_their_binding_protein -LRB- IGFBP-3 -RRB- are not elevated in pancreatic_cancer .
9497875	0	IGFBP-3	71,78	IGF-I	116,121	IGFBP-3	IGF-I	3486	3479	Gene	Gene	subunit|dep|START_ENTITY infusion|nmod|subunit infusion|appos|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9497875	0	IGFBP-3	71,78	IGF-I	41,46	IGFBP-3	IGF-I	3486	3479	Gene	Gene	subunit|dep|START_ENTITY infusion|nmod|subunit infusion|nmod|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9829225	0	IGFBP-3	204,211	IGF-I	170,175	IGFBP-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Treatment of peripubertal children after renal transplantation -LRB- RTX -RRB- with recombinant human growth hormone : auxological data and effects on insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- during 24 months .
7543116	0	IGFBP-3	68,75	IGF-II	147,153	IGFBP-3	IGF-II	3486	3481	Gene	Gene	levels|dep|START_ENTITY levels|dep|relation relation|nmod|index index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
10700718	0	IGFBP-3	61,68	IGF-binding_protein-3	38,59	IGFBP-3	IGF-binding protein-3	3486	3486	Gene	Gene	efficiency|appos|START_ENTITY efficiency|nmod|serum serum|nummod|END_ENTITY	Diagnostic efficiency of serum IGF-I , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and urinary GH measurements in the diagnosis of adult_GH_deficiency : importance of an appropriate reference population .
23831640	0	IGFBP-3	28,35	IGF1R	46,51	IGFBP-3	IGF1R	3486	3480	Gene	Gene	expression|nmod|START_ENTITY regulates|nsubj|expression regulates|dobj|END_ENTITY	TGF-b-induced expression of IGFBP-3 regulates IGF1R signaling in human osteosarcoma cells .
20155489	0	IGFBP-3	84,91	IGFBP-1	74,81	IGFBP-3	IGFBP-1	3486	3484	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Common_genetic_variation_of_insulin-like_growth factor-binding protein 1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and acid labile subunit in relation to serum IGF-I levels and mammographic density .
7543116	0	IGFBP-3	68,75	IGFBP-1	155,162	IGFBP-3	IGFBP-1	3486	3484	Gene	Gene	levels|dep|START_ENTITY levels|dep|relation relation|nmod|index index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
9497875	0	IGFBP-3	71,78	IGFBP-1	62,69	IGFBP-3	IGFBP-1	3486	3484	Gene	Gene	subunit|dep|START_ENTITY subunit|compound|END_ENTITY	The effect of an intravenous infusion of IGF-I and insulin on IGFBP-1 , IGFBP-3 , acid labile subunit , free and bound IGF-I , catecholamines and potassium in normal volunteers during an amino_acid and glucose clamp .
9714057	0	IGFBP-3	69,76	IGFBP-1	100,107	IGFBP-3	IGFBP-1	3486	3484	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis , decreased IGFBP-1 expression and increased tumorigenicity .
7543116	0	IGFBP-3	68,75	IGFBP-2	164,171	IGFBP-3	IGFBP-2	3486	3485	Gene	Gene	levels|dep|START_ENTITY levels|dep|relation relation|nmod|index index|dep|END_ENTITY	Serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - binding_protein-3 -LRB- IGFBP-3 -RRB- in healthy infants , children , and adolescents : the relation to IGF-I , IGF-II , IGFBP-1 , IGFBP-2 , age , sex , body mass index , and pubertal maturation .
9714057	0	IGFBP-3	69,76	IGFBP-2	0,7	IGFBP-3	IGFBP-2	3486	3485	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|compound|END_ENTITY	IGFBP-2 expression in a human cell line is associated with increased IGFBP-3 proteolysis , decreased IGFBP-1 expression and increased tumorigenicity .
8691093	0	IGFBP-3	12,19	IGFBP-4	41,48	IGFBP-3	IGFBP-4	3486	3487	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of IGFBP-3 in the regulation of IGFBP-4 proteolysis .
11735239	0	IGFBP-3	10,17	IGFIR	90,95	IGFBP-3	IGFIR	3486	3480	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Effect of IGFBP-3 on IGF - and IGF-analogue-induced insulin-like growth factor-I receptor -LRB- IGFIR -RRB- signalling .
7546777	0	IGFBP-3	47,54	Insulin-like_growth_factor-I	0,28	IGFBP-3	Insulin-like growth factor-I	3486	3479	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- regulates IGFBP-3 and IGFBP-4 by multiple mechanisms in A549 human adenocarcinoma cells .
24878287	0	IGFBP-3	34,41	STAT-1	0,6	IGFBP-3	STAT-1	3486	6772	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	STAT-1 expression is regulated by IGFBP-3 in malignant_glioma cells and is a strong predictor of poor survival in patients with glioblastoma .
9843764	0	IGFBP-3	0,7	TGF-beta1	95,104	IGFBP-3	TGF-beta1	3486	7040	Gene	Gene	production|amod|START_ENTITY production|dep|regulation regulation|nmod|END_ENTITY	IGFBP-3 and IGFBP-5 production by human intestinal muscle : reciprocal regulation by endogenous TGF-beta1 .
25086184	0	IGFBP-3	0,7	TNF-a	17,22	IGFBP-3	TNF-a	3486	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	IGFBP-3 inhibits TNF-a production and TNFR-2 signaling to protect against Retinal Endothelial Cell Apoptosis .
16541420	0	IGFBP-3	27,34	androgen_receptor	42,59	IGFBP-3	androgen receptor	3486	367	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of IGFBP-3 by the androgen_receptor in the lineage-related androgen-dependent LNCaP and androgen-independent C4-2 prostate_cancer models .
10668288	0	IGFBP-3	98,105	growth_hormone	128,142	IGFBP-3	growth hormone	3486	2688	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY measurement|nmod|insulin-like_growth_factor Usefulness|nmod|measurement Usefulness|nmod|diagnosis diagnosis|nmod|_ _|amod|END_ENTITY	-LSB- Usefulness of the measurement of insulin-like_growth_factor -LRB- IGF-I -RRB- and IGF-1_binding_protein-3 -LRB- IGFBP-3 -RRB- for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in children -RSB- .
7524925	0	IGFBP-3	83,90	growth_hormone	124,138	IGFBP-3	growth hormone	3486	2688	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY Comparison|nmod|insulin-like_growth_factor-I measurement|nsubj|Comparison measurement|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7688379	0	IGFBP-3	206,213	growth_hormone	14,28	IGFBP-3	growth hormone	3486	2688	Gene	Gene	insulin-like_growth_factor-1|appos|START_ENTITY changes|nmod|insulin-like_growth_factor-1 treatment|dep|changes treatment|amod|END_ENTITY	Supplementary growth_hormone treatment of women with poor ovarian response to exogenous gonadotrophins : changes in serum and follicular fluid insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- .
15775992	0	IGFBP-3	87,94	insulin-like_growth_factor-1	23,51	IGFBP-3	insulin-like growth factor-1	3486	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Putative role of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels in the development of prostate_cancer in Arab men .
15140235	0	IGFBP-3	68,75	insulin-like_growth_factor-binding_protein-3	22,66	IGFBP-3	insulin-like growth factor-binding protein-3	3486	3486	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP-3 -RRB- in Squamous_cell_carcinoma complicating recessive_dystrophic_epidermolysis_bullosa .
19944347	0	IGFBP-3	93,100	insulin-like_growth_factor_1	29,57	IGFBP-3	insulin-like growth factor 1	3486	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Anthropometric correlates of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels by race/ethnicity and gender .
15126555	0	IGFBP-3	128,135	insulin-like_growth_factor_I	67,95	IGFBP-3	insulin-like growth factor I	3486	3479	Gene	Gene	IGF-binding_protein-3|appos|START_ENTITY END_ENTITY|appos|IGF-binding_protein-3	Sustained elevation of pulsatile growth_hormone -LRB- GH -RRB- secretion and insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women .
12599210	0	IGFBP-3	54,61	insulin-like_growth_factor_binding_protein-3	8,52	IGFBP-3	insulin-like growth factor binding protein-3	3486	3486	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in the differentiation of primary human adult skeletal myoblasts .
15817480	0	IGFBP-3	150,157	insulin-like_growth_factor_binding_protein-3	104,148	IGFBP-3	insulin-like growth factor binding protein-3	3486	3486	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a novel positive transcription regulatory element that differentially regulates the insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- gene in senescent cells .
9077473	0	IGFBP-3	60,67	insulin-like_growth_factor_binding_protein-3	14,58	IGFBP-3	insulin-like growth factor binding protein-3	3486	3486	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in the psoriatic_lesion .
9699724	0	IGFBP-3	75,82	insulin-like_growth_factor_binding_protein-3	29,73	IGFBP-3	insulin-like growth factor binding protein-3	3486	3486	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Intranuclear localization of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- during cell division in human keratinocytes .
25553725	0	IGFBP-3	65,72	insulin-like_growth_factor_binding_protein_3	19,63	IGFBP-3	insulin-like growth factor binding protein 3	3486	3486	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of the insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- polymorphism with longevity in Chinese nonagenarians and centenarians .
1716700	0	IGFBP-3	64,71	insulin_like_growth_factor-binding_protein_3	18,62	IGFBP-3	insulin like growth factor-binding protein 3	3486	3486	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the insulin_like_growth_factor-binding_protein_3 -LRB- IGFBP-3 -RRB- gene is increased in human renal_carcinomas .
26722313	0	IGFBP-3	71,78	miR-155	82,89	IGFBP-3	miR-155	3486	406947	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Transcriptional activation of the IGF-II/IGF -1 R axis and inhibition of IGFBP-3 by miR-155 in hepatocellular_carcinoma .
25073020	0	IGFBP-3	14,21	p38a	44,48	IGFBP-3	p38a	3486	1432	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	TNFa inhibits IGFBP-3 through activation of p38a and casein kinase 2 in human retinal endothelial cells .
8818797	0	IGFBP-3	144,151	transforming_growth_factor_beta-1	99,132	IGFBP-3	transforming growth factor beta-1	3486	7040	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Cultured porcine myogenic cells produce insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- and transforming_growth_factor_beta-1 stimulates IGFBP-3 production .
8691093	0	IGFBP-4	41,48	IGFBP-3	12,19	IGFBP-4	IGFBP-3	3487	3486	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of IGFBP-3 in the regulation of IGFBP-4 proteolysis .
23660500	0	IGFBP-4	24,31	SOX9	0,4	IGFBP-4	SOX9	16010(Tax:10090)	20682(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SOX9 directly regulates IGFBP-4 in the intestinal epithelium .
11380497	0	IGFBP-4	63,70	insulin-like_growth_factor_binding_protein-4	17,61	IGFBP-4	insulin-like growth factor binding protein-4	3487	3487	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of insulin-like_growth_factor_binding_protein-4 -LRB- IGFBP-4 -RRB- under normal and pathological conditions .
9359468	0	IGFBP-4	90,97	insulin-like_growth_factor_binding_protein-4	44,88	IGFBP-4	insulin-like growth factor binding protein-4	360622(Tax:10116)	360622(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-alpha stimulates insulin-like_growth_factor_binding_protein-4 -LRB- IGFBP-4 -RRB- expression and blocks follicle-stimulating hormone regulation of IGFBP-4 production in rat granulosa cells .
15541345	0	IGFBP-4	0,7	pregnancy-associated_plasma_protein-A	23,60	IGFBP-4	pregnancy-associated plasma protein-A	16010(Tax:10090)	18491(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	IGFBP-4 degradation by pregnancy-associated_plasma_protein-A in MC3T3 osteoblasts .
12193414	0	IGFBP-4	165,172	protein_kinase-C	100,116	IGFBP-4	protein kinase-C	360622(Tax:10116)	24681(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Regulation of granulosa cell-derived insulin-like growth factor binding proteins -LRB- IGFBPs -RRB- : role for protein_kinase-C in the pre - and posttranslational modulation of IGFBP-4 and IGFBP-5 .
26103640	0	IGFBP-5	0,7	Nucleolin	101,110	IGFBP-5	Nucleolin	3488	4691	Gene	Gene	Independently|compound|START_ENTITY Independently|nmod|END_ENTITY	IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF .
10218991	0	IGFBP-5	77,84	insulin-like_growth_factor_binding_protein-5	31,75	IGFBP-5	insulin-like growth factor binding protein-5	3488	3488	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen_receptor up-regulates insulin-like_growth_factor_binding_protein-5 -LRB- IGFBP-5 -RRB- expression in a human prostate_cancer xenograft .
19948051	0	IGFBP-5	18,25	miR-140	60,67	IGFBP-5	miR-140	3488	406932	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes .
25601855	0	IGFBP-6	70,77	Insulin-Like_Growth_Factor_Binding_Protein-6	24,68	IGFBP-6	Insulin-Like Growth Factor Binding Protein-6	3489	3489	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Differential Effects of Insulin-Like_Growth_Factor_Binding_Protein-6 -LRB- IGFBP-6 -RRB- on Migration of Two Ovarian_Cancer Cell Lines .
18985860	0	IGFBP-6	18,25	SEMA3B	77,83	IGFBP-6	SEMA3B	3489	7869	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3B .
22392074	0	IGFBP-rP1	0,9	p21	18,21	IGFBP-rP1	p21	3490	1026	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IGFBP-rP1 induces p21 expression through a p53-independent pathway , leading to cellular senescence of MCF-7 breast_cancer cells .
26232425	0	IGFBP1	94,100	HNF4a	30,35	IGFBP1	HNF4a	3484	3172	Gene	Gene	START_ENTITY|nsubj|Gene Gene|compound|END_ENTITY	Pregnane_X_Receptor Represses HNF4a Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells .
26232425	0	IGFBP1	94,100	Pregnane_X_Receptor	0,19	IGFBP1	Pregnane X Receptor	3484	8856	Gene	Gene	START_ENTITY|nsubj|Gene Gene|compound|END_ENTITY	Pregnane_X_Receptor Represses HNF4a Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells .
23045290	0	IGFBP10	40,47	CYR61	33,38	IGFBP10	CYR61	3491	3491	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A functional polymorphism in the CYR61 -LRB- IGFBP10 -RRB- gene is associated with prostate_cancer risk .
25893308	0	IGFBP2	0,6	EGFR-STAT3	27,37	IGFBP2	EGFR-STAT3	3485	1956;6774	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	IGFBP2 potentiates nuclear EGFR-STAT3 signaling .
26559475	0	IGFBP2	58,64	Insulin-Like_Growth_Factor_Binding_Protein_2	12,56	IGFBP2	Insulin-Like Growth Factor Binding Protein 2	3485	3485	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Insulin-Like_Growth_Factor_Binding_Protein_2 -LRB- IGFBP2 -RRB- in the Regulation of Corneal Fibroblast Differentiation .
17619941	0	IGFBP3	147,153	IGF-1	116,121	IGFBP3	IGF-1	3486	3479	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|irradiation irradiation|nmod|release release|appos|insulin_like_growth_factor-1 insulin_like_growth_factor-1|appos|END_ENTITY	Effects of laser irradiation on the release of basic_fibroblast_growth_factor -LRB- bFGF -RRB- , insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- , and receptor of IGF-1 -LRB- IGFBP3 -RRB- from gingival fibroblasts .
22482470	0	IGFBP3	9,15	IGF-1	66,71	IGFBP3	IGF-1	3486	3479	Gene	Gene	levels|compound|START_ENTITY levels|dep|regulator regulator|nmod|END_ENTITY	Elevated IGFBP3 levels in diabetic tears : a negative regulator of IGF-1 signaling in the corneal epithelium .
24427493	0	IGFBP3	138,144	IGF-1	81,86	IGFBP3	IGF-1	3486	3479	Gene	Gene	Levels|appos|START_ENTITY Prevent|nsubj|Levels protein|acl:relcl|Prevent _|dobj|protein _|nsubj|_ _|appos|END_ENTITY	Early Aggressive Parenteral Nutrition Induced High_Insulin-like_growth_factor_1 _ -LRB- IGF-1 -RRB- _ and_insulin-like_growth factor binding protein 3 -LRB- IGFBP3 -RRB- Levels Can Prevent Risk of Retinopathy_of_Prematurity .
9541512	0	IGFBP3	143,149	IGF-1	89,94	IGFBP3	IGF-1	16009(Tax:10090)	16000(Tax:10090)	Gene	Gene	insulin-like_growth_factor|appos|START_ENTITY insulin-like_growth_factor|appos|END_ENTITY	Regulation of experimental_autoimmune_encephalomyelitis with insulin-like_growth_factor -LRB- IGF-1 -RRB- and IGF-1 / IGF-binding_protein-3 complex -LRB- IGF-1 / IGFBP3 -RRB- .
17332286	0	IGFBP3	44,50	IGFBP4	52,58	IGFBP3	IGFBP4	3486	3487	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Insulin-like growth factor binding proteins IGFBP3 , IGFBP4 , and IGFBP5 predict endocrine responsiveness in patients with ovarian_cancer .
24386080	0	IGFBP3	0,6	homeobox_D10	36,48	IGFBP3	homeobox D10	3486	3236	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	IGFBP3 , a transcriptional target of homeobox_D10 , is correlated with the prognosis of gastric_cancer .
21892705	0	IGFBP3	141,147	insulin-like_growth_factor-binding_protein-3	95,139	IGFBP3	insulin-like growth factor-binding protein-3	3486	3486	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Urinary_bladder_cancer risk in relation to a single nucleotide polymorphism -LRB- rs2854744 -RRB- in the insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP3 -RRB- gene .
23464449	0	IGFBP3	122,128	insulin-like_growth_factor-binding_protein-3	76,120	IGFBP3	insulin-like growth factor-binding protein-3	3486	3486	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prostate_cancer risk in relation to a single nucleotide polymorphism in the insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP3 -RRB- gene : a meta-analysis .
19341330	0	IGFBP3	117,123	insulin-like_growth_factor_binding_protein-3	71,115	IGFBP3	insulin-like growth factor binding protein-3	16009(Tax:10090)	16009(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Estradiol , progesterone , and transforming_growth_factor_alpha regulate insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- expression in mouse endometrial cells .
24809065	0	IGFBP3	104,110	insulin-like_growth_factor_binding_protein-3	58,102	IGFBP3	insulin-like growth factor binding protein-3	3486	3486	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Maximal oxygen uptake is associated with allele -202 A of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- promoter polymorphism and -LRB- CA -RRB- n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland .
15661074	0	IGFBP3	56,62	p53	29,32	IGFBP3	p53	3486	7157	Gene	Gene	sequence|nmod|START_ENTITY sequence|compound|END_ENTITY	Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation .
17332286	0	IGFBP4	52,58	IGFBP3	44,50	IGFBP4	IGFBP3	3487	3486	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Insulin-like growth factor binding proteins IGFBP3 , IGFBP4 , and IGFBP5 predict endocrine responsiveness in patients with ovarian_cancer .
9615225	0	IGFBP4	103,109	insulin-like_growth_factor_binding_protein_4	52,96	IGFBP4	insulin-like growth factor binding protein 4	3487	3487	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and transcription regulation of the human insulin-like_growth_factor_binding_protein_4 gene -LRB- IGFBP4 -RRB- .
19897600	0	IGFBP5	54,60	insulin-like_growth_factor-binding_protein_5	8,52	IGFBP5	insulin-like growth factor-binding protein 5	16011(Tax:10090)	16011(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of insulin-like_growth_factor-binding_protein_5 -LRB- IGFBP5 -RRB- in organismal and pancreatic beta-cell growth .
11960310	0	IGFBP5	79,85	insulin-like_growth_factor_binding_protein-5	33,77	IGFBP5	insulin-like growth factor binding protein-5	3488	3488	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The IDDM13 region containing the insulin-like_growth_factor_binding_protein-5 -LRB- IGFBP5 -RRB- gene on chromosome 2q33-q36 and the genetic susceptibility to rheumatoid_arthritis .
19019211	0	IGFBP7	35,41	IGF-binding_protein_7	12,33	IGFBP7	IGF-binding protein 7	3490	3490	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Circulating IGF-binding_protein_7 -LRB- IGFBP7 -RRB- levels are elevated in patients with endometriosis or undergoing diabetic_hemodialysis .
26974954	0	IGFBP7	55,61	IGFBP7	8,14	IGFBP7	IGFBP7	3490	3490	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of IGFBP7 in Diabetic_Nephropathy : TGF-b1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells .
26974954	0	IGFBP7	8,14	IGFBP7	55,61	IGFBP7	IGFBP7	3490	3490	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of IGFBP7 in Diabetic_Nephropathy : TGF-b1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells .
23543219	0	IGFBP7	46,52	Insulin-like_growth_factor-binding_protein-7	0,44	IGFBP7	Insulin-like growth factor-binding protein-7	3490	3490	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Insulin-like_growth_factor-binding_protein-7 -LRB- IGFBP7 -RRB- transcript : A-to-I editing events in normal and cancerous human keratinocytes .
25887188	0	IGFBP7	46,52	Insulin_like_growth_factor_binding_protein_7	0,44	IGFBP7	Insulin like growth factor binding protein 7	3490	3490	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Insulin_like_growth_factor_binding_protein_7 -LRB- IGFBP7 -RRB- expression is linked to poor prognosis but may protect from bone_disease in multiple_myeloma .
25887188	0	IGFBP7	46,52	Insulin_like_growth_factor_binding_protein_7	0,44	IGFBP7	Insulin like growth factor binding protein 7	3490	3490	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Insulin_like_growth_factor_binding_protein_7 -LRB- IGFBP7 -RRB- expression is linked to poor prognosis but may protect from bone_disease in multiple_myeloma .
26522657	0	IGFBP7	66,72	TIMP2	77,82	IGFBP7	TIMP2	3490	7077	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Reference intervals of urinary acute_kidney_injury -LRB- AKI -RRB- markers -LSB- IGFBP7 -RSB- -LSB- TIMP2 -RSB- in apparently healthy subjects and chronic comorbid subjects without AKI .
26816218	0	IGFBP7	8,14	TIMP2	0,5	IGFBP7	TIMP2	3490	7077	Gene	Gene	panel|compound|START_ENTITY panel|nummod|END_ENTITY	TIMP2 IGFBP7 biomarker panel accurately predicts acute_kidney_injury in high-risk surgical patients .
25212428	0	IGFBP7	67,73	insulin-like_growth_factor-binding_protein-7	21,65	IGFBP7	insulin-like growth factor-binding protein-7	289560(Tax:10116)	289560(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of insulin-like_growth_factor-binding_protein-7 -LRB- IGFBP7 -RRB- on in vitro angiogenesis of vascular endothelial cells in the rat corpus luteum .
21413833	0	IGFBP7	73,79	insulin-like_growth_factor-binding_protein_7	27,71	IGFBP7	insulin-like growth factor-binding protein 7	3490	3490	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Function and expression of insulin-like_growth_factor-binding_protein_7 -LRB- IGFBP7 -RRB- gene in childhood acute_myeloid_leukemia .
21095038	0	IGFBP7	0,6	p53	12,15	IGFBP7	p53	3490	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	IGFBP7 is a p53 target gene inactivated in human lung_cancer by DNA hypermethylation .
10619489	0	IGFII	49,54	IGFIR	131,136	IGFII	IGFIR	3481	3480	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Overexpression_of_insulin-like_growth factor II -LRB- IGFII -RRB- in ZR-75-1 human breast_cancer cells : higher threshold levels of receptor -LRB- IGFIR -RRB- are required for a proliferative response than for effects on specific gene expression .
11735239	0	IGFIR	90,95	IGFBP-3	10,17	IGFIR	IGFBP-3	3480	3486	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Effect of IGFBP-3 on IGF - and IGF-analogue-induced insulin-like growth factor-I receptor -LRB- IGFIR -RRB- signalling .
10619489	0	IGFIR	131,136	IGFII	49,54	IGFIR	IGFII	3480	3481	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Overexpression_of_insulin-like_growth factor II -LRB- IGFII -RRB- in ZR-75-1 human breast_cancer cells : higher threshold levels of receptor -LRB- IGFIR -RRB- are required for a proliferative response than for effects on specific gene expression .
17116363	0	IGFR-1	140,146	IGF-I	112,117	IGFR-1	IGF-I	281848(Tax:9913)	104978413	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- system during follicle development in the bovine ovary : relationship among IGF-I , type 1 IGF receptor -LRB- IGFR-1 -RRB- and pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- .
17116363	0	IGFR-1	140,146	IGF-I	30,35	IGFR-1	IGF-I	281848(Tax:9913)	104978413	Gene	Gene	receptor|appos|START_ENTITY relationship|nmod|receptor system|dep|relationship system|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- system during follicle development in the bovine ovary : relationship among IGF-I , type 1 IGF receptor -LRB- IGFR-1 -RRB- and pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- .
9496257	0	IGFR-1	63,69	insulin-like_growth_factor_receptor_1	24,61	IGFR-1	insulin-like growth factor receptor 1	100132417	100132417	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	The localization of the insulin-like_growth_factor_receptor_1 -LRB- IGFR-1 -RRB- in benign and malignant breast tissue .
2396672	0	IGF_I	26,31	Growth_hormone	0,14	IGF I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Growth_hormone stimulates IGF_I gene expression in isolated rat renal collecting duct .
9588214	0	IGF_I	0,5	p53	19,22	IGF I	p53	3479	7157	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	IGF_I induction of p53 requires activation of MAP kinase in cardiac muscle cells .
11248749	0	IGF_binding_protein-1	12,33	leptin	63,69	IGF binding protein-1	leptin	3484	3952	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Circulating IGF_binding_protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women .
10971450	0	IGF_binding_protein-3	55,76	IGF-I	47,52	IGF binding protein-3	IGF-I	3486	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Monitoring serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- , IGF-I/IGFBP -3 molar ratio and leptin during growth hormone treatment for disordered growth .
9614361	0	IGF_binding_protein-3	152,173	IGF-I	33,38	IGF binding protein-3	IGF-I	3486	3479	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|administration administration|compound|END_ENTITY	The effects of recombinant human IGF-I administration on concentrations of acid_labile_subunit , IGF_binding_protein-3 , IGF-I , IGF-II and proteolysis of IGF_binding_protein-3 in adolescents with insulin-dependent_diabetes_mellitus .
20472501	0	IGF_binding_protein_3	37,58	IGF1	30,34	IGF binding protein 3	IGF1	3486	3479	Gene	Gene	Insulin-like_growth_factor_1|appos|START_ENTITY Insulin-like_growth_factor_1|appos|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF1 -RRB- , IGF_binding_protein_3 -LRB- IGFBP3 -RRB- , and breast_cancer risk : pooled individual data analysis of 17 prospective studies .
1373347	0	IGF_binding_protein_3	0,21	rIGF-I	80,86	IGF binding protein 3	rIGF-I	3486	24482(Tax:10116)	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	IGF_binding_protein_3 in patients with Laron_type_dwarfism : effect of exogenous rIGF-I .
25511139	0	IGH	83,86	CDKN2A	75,81	IGH	CDKN2A	3492	1029	Gene	Gene	Alterations|appos|START_ENTITY Alterations|appos|END_ENTITY	Cytogenetic and Flow Cytometry Evaluation of Richter_Syndrome Reveals MYC , CDKN2A , IGH Alterations With Loss of CD52 , CD62L and Increase of CD71 Antigen Expression as the Most Frequent Recurrent Abnormalities .
17639584	0	IGH	42,45	immunoglobulin_heavy-chain	14,40	IGH	immunoglobulin heavy-chain	238412(Tax:10090)	238412(Tax:10090)	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	In a model of immunoglobulin_heavy-chain -LRB- IGH -RRB- / MYC translocation , the Igh_3 ' regulatory region induces MYC expression at the immature stage of B cell development .
20441787	0	IGHMBP2	53,60	Smubp-2	62,69	IGHMBP2	Smubp-2	3508	3508	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the promoter region of the human IGHMBP2 -LRB- Smubp-2 -RRB- gene and its response to TPA in HL-60 cells .
18483396	0	IGHV4-34	129,137	IGKV1	138,143	IGHV4-34	IGKV1	28395	3519	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Primary_cystic_lung_light_chain_deposition_disease : a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34 / IGKV1 receptor .
18483396	0	IGKV1	138,143	IGHV4-34	129,137	IGKV1	IGHV4-34	3519	28395	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Primary_cystic_lung_light_chain_deposition_disease : a clinicopathologic entity derived from unmutated B cells with a stereotyped IGHV4-34 / IGKV1 receptor .
11297555	0	IGRP	122,126	islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein	50,120	IGRP	islet-specific glucose-6-phosphatase catalytic subunit-related protein	681817(Tax:10116)	681817(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Cloning and characterization of the human and rat islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein -LRB- IGRP -RRB- genes .
26163525	0	IGSF1	72,77	immunoglobulin_superfamily_member_1	35,70	IGSF1	immunoglobulin superfamily member 1	302822(Tax:10116)	302822(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Spatial and temporal expression of immunoglobulin_superfamily_member_1 -LRB- IGSF1 -RRB- in the rat .
21784897	0	IHG-1	0,5	PGC-1a	55,61	IHG-1	PGC-1a	54974	10891	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1a .
8797089	0	IHRP	110,114	ITIHL1	122,128	IHRP	ITIHL1	3700	3700	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene -LRB- ITIHL1 -RRB- .
12147176	0	IHRP	86,90	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	20,84	IHRP	inter-alpha-trypsin inhibitor family heavy chain-related protein	3700	3700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SNP analysis of the inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene by a fluorescence-adapted SSCP method .
8797089	0	IHRP	110,114	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	44,108	IHRP	inter-alpha-trypsin inhibitor family heavy chain-related protein	3700	3700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene -LRB- ITIHL1 -RRB- .
21380797	0	IIA	75,78	MYH9	80,84	IIA	MYH9	4627	4627	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA -LRB- MYH9 protein -RRB- in human podocytes .
11171584	0	IIB	16,19	myosin_heavy_chain	20,38	IIB	myosin heavy chain	50771(Tax:10090)	111671(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Mutation of the IIB myosin_heavy_chain gene results in muscle fiber loss and compensatory_hypertrophy .
22296971	0	IIb	20,23	Nurr1	0,5	IIb	Nurr1	50771(Tax:10090)	18227(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Nurr1 regulates Top IIb and functions in axon genesis of mesencephalic dopaminergic neurons .
14617774	0	IIp45	0,5	IGFBP-2	56,63	IIp45	IGFBP-2	60672	3485	Gene	Gene	START_ENTITY|appos|protein protein|appos|END_ENTITY	IIp45 , an insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- binding protein , antagonizes IGFBP-2 stimulation of glioma_cell_invasion .
23691078	0	IKBKE	0,5	FOXO3a	40,46	IKBKE	FOXO3a	9641	2309	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	IKBKE phosphorylation and inhibition of FOXO3a : a mechanism of IKBKE oncogenic function .
23691078	0	IKBKE	63,68	FOXO3a	40,46	IKBKE	FOXO3a	9641	2309	Gene	Gene	function|amod|START_ENTITY mechanism|nmod|function phosphorylation|dep|mechanism phosphorylation|nmod|END_ENTITY	IKBKE phosphorylation and inhibition of FOXO3a : a mechanism of IKBKE oncogenic function .
19168710	0	IKK-2	59,64	IkappaB_kinase-2	41,57	IKK-2	IkappaB kinase-2	3551	3551	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel , highly selective , tight binding IkappaB_kinase-2 -LRB- IKK-2 -RRB- inhibitor : a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models .
9520446	0	IKK-alpha	36,45	NF-kappaB-inducing_kinase	0,25	IKK-alpha	NF-kappaB-inducing kinase	1147	9020	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	NF-kappaB-inducing_kinase activates IKK-alpha by phosphorylation of Ser-176 .
19929594	0	IKK-beta	9,17	interferon-gamma	73,89	IKK-beta	interferon-gamma	16150(Tax:10090)	15978(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of IKK-beta , IRF1 , and p65 in the activation of chemokine genes by interferon-gamma .
16333836	0	IKK-gamma	37,46	NEMO	31,35	IKK-gamma	NEMO	8517	8517	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel splicing mutation in the NEMO -LRB- IKK-gamma -RRB- gene with severe immunodeficiency and heterogeneity of X-chromosome inactivation .
16199137	0	IKK-i	0,5	IRF3	22,26	IKK-i	IRF3	9641	3661	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines .
11902829	0	IKK-i	55,60	IkappaB_kinase	39,53	IKK-i	IkappaB kinase	9641	9641	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of inducible IkappaB_kinase -LRB- IKK-i -RRB- in human fibroblast-like synoviocytes .
15723090	0	IKK_beta	129,137	IKK_beta	14,22	IKK beta	IKK beta	3551	3551	Gene	Gene	Validation|nmod|START_ENTITY Validation|nmod|END_ENTITY	Validation of IKK_beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK_beta to pulmonary epithelial cells .
15723090	0	IKK_beta	14,22	IKK_beta	129,137	IKK beta	IKK beta	3551	3551	Gene	Gene	Validation|nmod|START_ENTITY Validation|nmod|END_ENTITY	Validation of IKK_beta as therapeutic target in airway inflammatory disease by adenoviral-mediated delivery of dominant-negative IKK_beta to pulmonary epithelial cells .
12167626	0	IKK_beta	0,8	NF-kappa_B	40,50	IKK beta	NF-kappa B	3551	4790	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	IKK_beta is required for Bcl-2-mediated NF-kappa_B activation in ventricular myocytes .
16887350	0	IKK_epsilon	0,11	IAP1	69,73	IKK epsilon	IAP1	35329(Tax:7227)	39753(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	IKK_epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis .
15198984	0	IKK_gamma	49,58	Hsp70	0,5	IKK gamma	Hsp70	8517	3308	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Hsp70 promotes TNF-mediated apoptosis by binding IKK_gamma and impairing NF-kappa_B survival signaling .
10723136	0	IKK_gamma	104,113	NF-kappa_B	117,127	IKK gamma	NF-kappa B	8517	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Somatic mutagenesis studies of NF-kappa_B signaling in human T cells : evidence for an essential role of IKK_gamma in NF-kappa_B activation by T-cell costimulatory signals and HTLV-I Tax protein .
10723136	0	IKK_gamma	104,113	NF-kappa_B	31,41	IKK gamma	NF-kappa B	8517	4790	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role studies|dep|evidence studies|nmod|END_ENTITY	Somatic mutagenesis studies of NF-kappa_B signaling in human T cells : evidence for an essential role of IKK_gamma in NF-kappa_B activation by T-cell costimulatory signals and HTLV-I Tax protein .
18207244	0	IKK_gamma	39,48	NF-kappa_B	73,83	IKK gamma	NF-kappa B	8517	4790	Gene	Gene	domain|nmod|START_ENTITY Mutations|nmod|domain block|nsubj|Mutations block|dobj|activation activation|nmod|END_ENTITY	Mutations in the zinc finger domain of IKK_gamma block the activation of NF-kappa_B and the induction of IL-2 in stimulated T lymphocytes .
10648602	0	IKKalpha	54,62	IKKbeta	115,122	IKKalpha	IKKbeta	1147	3551	Gene	Gene	IkappaB|appos|START_ENTITY Activation|nmod|IkappaB Activation|dep|END_ENTITY	Activation of the heterodimeric IkappaB kinase alpha -LRB- IKKalpha -RRB- - IKKbeta complex is directional : IKKalpha regulates IKKbeta under both basal and stimulated conditions .
10648602	0	IKKalpha	54,62	IKKbeta	64,71	IKKalpha	IKKbeta	1147	3551	Gene	Gene	IkappaB|appos|START_ENTITY Activation|nmod|IkappaB Activation|parataxis|directional directional|nsubj|complex complex|compound|END_ENTITY	Activation of the heterodimeric IkappaB kinase alpha -LRB- IKKalpha -RRB- - IKKbeta complex is directional : IKKalpha regulates IKKbeta under both basal and stimulated conditions .
10648602	0	IKKalpha	96,104	IKKbeta	64,71	IKKalpha	IKKbeta	1147	3551	Gene	Gene	IKKbeta|compound|START_ENTITY Activation|dep|IKKbeta Activation|parataxis|directional directional|nsubj|complex complex|compound|END_ENTITY	Activation of the heterodimeric IkappaB kinase alpha -LRB- IKKalpha -RRB- - IKKbeta complex is directional : IKKalpha regulates IKKbeta under both basal and stimulated conditions .
10779355	0	IKKalpha	22,30	IKKbeta	46,53	IKKalpha	IKKbeta	1147	3551	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	IkappaB_kinase_alpha -LRB- IKKalpha -RRB- regulation of IKKbeta kinase activity .
19104039	0	IKKalpha	13,21	IKKbeta	73,80	IKKalpha	IKKbeta	1147	3551	Gene	Gene	activation|compound|START_ENTITY activation|nmod|NF-kappaB NF-kappaB|acl|signaling signaling|nmod|inhibition inhibition|compound|END_ENTITY	Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen .
19838210	0	IKKalpha	70,78	Notch-1	0,7	IKKalpha	Notch-1	1147	4851	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Notch-1 activates estrogen_receptor-alpha-dependent transcription via IKKalpha in breast_cancer cells .
16616828	0	IKKalpha	0,8	beta-catenin	30,42	IKKalpha	beta-catenin	1147	1499	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways .
18633439	0	IKKalpha	0,8	p63	14,17	IKKalpha	p63	1147	8626	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal_dysplasias .
22614018	0	IKKb	35,39	ATM	59,62	IKKb	ATM	3551	472	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Promotion of DNA repair by nuclear IKKb phosphorylation of ATM in response to genotoxic stimuli .
24290981	0	IKKb	57,61	RAPGEF2	96,103	IKKb	RAPGEF2	3551	9693	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Control of epithelial cell migration and invasion by the IKKb - and CK1a-mediated degradation of RAPGEF2 .
25637316	0	IKKb	0,4	VEGF	15,19	IKKb	VEGF	3551	7422	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|compound|END_ENTITY	IKKb Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Antiangiogenic Treatment .
22848663	0	IKKb	63,67	mTOR	40,44	IKKb	mTOR	3551	21977(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|xcomp|signaling	Hepatitis_B_virus X protein upregulates mTOR signaling through IKKb to increase cell proliferation and VEGF production in hepatocellular_carcinoma .
26102347	0	IKKb	8,12	p65	27,30	IKKb	p65	16150(Tax:10090)	19697(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY END_ENTITY|nsubj|Loss	Loss of IKKb but Not NF-kB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells .
26718331	0	IKKb	39,43	p65	27,30	IKKb	p65	3551	5970	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Survivin activates NF - kB p65 via the IKKb promoter in esophageal_squamous_cell_carcinoma .
19258594	0	IKKbeta	73,80	BAFF-R	0,6	IKKbeta	BAFF-R	3551	115650	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|nsubj|END_ENTITY	BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells .
10648602	0	IKKbeta	115,122	IKKalpha	54,62	IKKbeta	IKKalpha	3551	1147	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|IkappaB IkappaB|appos|END_ENTITY	Activation of the heterodimeric IkappaB kinase alpha -LRB- IKKalpha -RRB- - IKKbeta complex is directional : IKKalpha regulates IKKbeta under both basal and stimulated conditions .
10648602	0	IKKbeta	64,71	IKKalpha	54,62	IKKbeta	IKKalpha	3551	1147	Gene	Gene	complex|compound|START_ENTITY directional|nsubj|complex Activation|parataxis|directional Activation|nmod|IkappaB IkappaB|appos|END_ENTITY	Activation of the heterodimeric IkappaB kinase alpha -LRB- IKKalpha -RRB- - IKKbeta complex is directional : IKKalpha regulates IKKbeta under both basal and stimulated conditions .
10648602	0	IKKbeta	64,71	IKKalpha	96,104	IKKbeta	IKKalpha	3551	1147	Gene	Gene	complex|compound|START_ENTITY directional|nsubj|complex Activation|parataxis|directional Activation|dep|IKKbeta IKKbeta|compound|END_ENTITY	Activation of the heterodimeric IkappaB kinase alpha -LRB- IKKalpha -RRB- - IKKbeta complex is directional : IKKalpha regulates IKKbeta under both basal and stimulated conditions .
10779355	0	IKKbeta	46,53	IKKalpha	22,30	IKKbeta	IKKalpha	3551	1147	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	IkappaB_kinase_alpha -LRB- IKKalpha -RRB- regulation of IKKbeta kinase activity .
19104039	0	IKKbeta	73,80	IKKalpha	13,21	IKKbeta	IKKalpha	3551	1147	Gene	Gene	inhibition|compound|START_ENTITY signaling|nmod|inhibition NF-kappaB|acl|signaling activation|nmod|NF-kappaB activation|compound|END_ENTITY	Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen .
20534585	0	IKKbeta	62,69	IkappaB_kinase-beta	41,60	IKKbeta	IkappaB kinase-beta	3551	3551	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Tyrosine phosphorylation is required for IkappaB_kinase-beta -LRB- IKKbeta -RRB- activation and function in osteoclastogenesis .
10779355	0	IKKbeta	46,53	IkappaB_kinase_alpha	0,20	IKKbeta	IkappaB kinase alpha	3551	1147	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	IkappaB_kinase_alpha -LRB- IKKalpha -RRB- regulation of IKKbeta kinase activity .
11971901	0	IKKbeta	59,66	NEMO	42,46	IKKbeta	NEMO	3551	8517	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Regulation of Ikappa_B_kinase _ -LRB- IKK -RRB- gamma / NEMO function by IKKbeta - mediated phosphorylation .
20152798	0	IKKbeta	0,7	P16	30,33	IKKbeta	P16	3551	1029	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	IKKbeta specifically binds to P16 and phosphorylates Ser8 of P16 .
19766100	0	IKKbeta	61,68	TNFalpha	0,8	IKKbeta	TNFalpha	3551	7124	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	TNFalpha induces HIF-1alpha expression through activation of IKKbeta .
16046471	0	IKKbeta	0,7	p65	23,26	IKKbeta	p65	16150(Tax:10090)	19697(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	IKKbeta phosphorylates p65 at S468 in transactivaton domain 2 .
17133498	0	IKKepsilon	19,29	IFN	74,77	IKKepsilon	IFN	9641	3439	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	The protein kinase IKKepsilon can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers .
14653779	0	IKKgamma	102,110	ABIN-2	14,20	IKKgamma	ABIN-2	8517	79155	Gene	Gene	interaction|nmod|START_ENTITY disrupts|dobj|interaction disrupts|nsubj|END_ENTITY	The inhibitor ABIN-2 disrupts the interaction of receptor-interacting_protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis .
15528996	0	IKKgamma	0,8	NIK	45,48	IKKgamma	NIK	16151(Tax:10090)	53859(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	IKKgamma inhibits activation of NF-kappaB by NIK .
11080796	0	IKKgamma	112,120	Tax	49,52	IKKgamma	Tax	8517	6900	Gene	Gene	function|nmod|START_ENTITY kinase|nmod|function kinase|nmod|protein protein|compound|END_ENTITY	Activation of I-kappaB kinase by the HTLV type 1 Tax protein : mechanistic insights into the adaptor function of IKKgamma .
10336413	0	IKKgamma	0,8	tax	71,74	IKKgamma	tax	8517	1491938(Tax:11908)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T_cell_leukemia_virus_type_1 .
8264864	0	IL-1	47,51	Alpha-melanocyte-stimulating_hormone	0,36	IL-1	Alpha-melanocyte-stimulating hormone	3552	5443	Gene	Gene	release|amod|START_ENTITY abolishes|dobj|release abolishes|nsubj|END_ENTITY	Alpha-melanocyte-stimulating_hormone abolishes IL-1 - and IL-6-induced corticotropin-releasing_factor release from the hypothalamus in vitro .
12925611	0	IL-1	62,66	BMP-2	15,20	IL-1	BMP-2	3553	650	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|expression expression|compound|END_ENTITY	Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes .
18477692	0	IL-1	25,29	CD25	70,74	IL-1	CD25	111343(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expansion/differentiation expansion/differentiation|nmod|+ +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
15048719	0	IL-1	0,4	CD4	103,106	IL-1	CD4	3552	920	Gene	Gene	acts|nsubj|START_ENTITY acts|xcomp|enhance enhance|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	IL-1 acts on antigen-presenting cells to enhance the in vivo proliferation of antigen-stimulated naive CD4 T cells via a CD28-dependent mechanism that does not involve increased expression of CD28 ligands .
1533149	0	IL-1	85,89	CD4	39,42	IL-1	CD4	111343(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY role|nmod|secretion requirements|dep|role requirements|nmod|+ +|compound|END_ENTITY	Similar co-stimulation requirements of CD4 + and CD8 + primary T helper cells : role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation .
18477692	0	IL-1	25,29	CD4	66,69	IL-1	CD4	111343(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expansion/differentiation expansion/differentiation|nmod|+ +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
19359475	0	IL-1	0,4	CD4	22,25	IL-1	CD4	3553	920	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|cells cells|compound|END_ENTITY	IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation .
20540113	0	IL-1	24,28	CD4	94,97	IL-1	CD4	111343(Tax:10090)	12504(Tax:10090)	Gene	Gene	members|compound|START_ENTITY interactions|nmod|members trigger|nsubj|interactions trigger|nmod|T T|compound|END_ENTITY	TGF-b interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4 -LRB- + -RRB- T cells .
21998454	0	IL-1	8,12	CD4	49,52	IL-1	CD4	3553	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Ex vivo IL-1 receptor type I expression in human CD4 + T cells identifies an early intermediate in the differentiation of Th17 from FOXP3 + naive regulatory T cells .
23181791	0	IL-1	26,30	CD4	80,83	IL-1	CD4	3552	920	Gene	Gene	START_ENTITY|nmod|IL-17A IL-17A|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Human eosinophils release IL-1 and increase expression of IL-17A in activated CD4 + T lymphocytes .
10202038	0	IL-1	38,42	CD44	20,24	IL-1	CD44	3552	960	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Characterization of CD44 induction by IL-1 : a critical role for Egr-1 .
19233959	0	IL-1	97,101	CXCL-1	31,37	IL-1	CXCL-1	3552	2919	Gene	Gene	response|nmod|START_ENTITY produce|nmod|response produce|xcomp|END_ENTITY	Prostate stromal cells produce CXCL-1 , CXCL-2 , CXCL-3 and IL-8 in response to epithelia-secreted IL-1 .
19101514	0	IL-1	0,4	Cyp7a1	19,25	IL-1	Cyp7a1	111343(Tax:10090)	13122(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice .
9973455	0	IL-1	102,106	Fas_ligand	0,10	IL-1	Fas ligand	3552	356	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Fas_ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1 , IL-6 , TNF-alpha , or IFN-gamma .
18477692	0	IL-1	25,29	Foxp3	75,80	IL-1	Foxp3	111343(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expansion/differentiation expansion/differentiation|nmod|+ +|compound|END_ENTITY	Costimulatory effects of IL-1 on the expansion/differentiation of CD4 + CD25 + Foxp3 + and CD4 + CD25 + Foxp3 - T cells .
7506580	0	IL-1	202,206	G-CSF	187,192	IL-1	G-CSF	3552	1440	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
1834679	0	IL-1	27,31	GM-CSF	0,6	IL-1	GM-CSF	3552	1437	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	GM-CSF in association with IL-1 triggers day-8 CFU-S into cell cycle : role of histamine .
7506580	0	IL-1	202,206	GM-CSF	194,200	IL-1	GM-CSF	3552	1437	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
2114443	0	IL-1	27,31	IFN-gamma	65,74	IL-4	IFN-gamma	3565	3458	Gene	Gene	production|compound|START_ENTITY regulation|nmod|production regulation|nmod|END_ENTITY	Differential regulation of IL-1 production in human monocytes by IFN-gamma and IL-4 .
17641006	0	IL-1	34,38	IL-1	88,92	IL-1	IL-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Cutting edge : opposite effects of IL-1 and IL-2 on the regulation of IL-17 + T cell pool IL-1 subverts IL-2-mediated suppression .
17641006	0	IL-1	88,92	IL-1	34,38	IL-1	IL-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Cutting edge : opposite effects of IL-1 and IL-2 on the regulation of IL-17 + T cell pool IL-1 subverts IL-2-mediated suppression .
2107255	0	IL-1	0,4	IL-1	13,17	IL-1	IL-1	3553	3553	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	IL-1 induces IL-1 .
2107255	0	IL-1	13,17	IL-1	0,4	IL-1	IL-1	3553	3553	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	IL-1 induces IL-1 .
2107255	2	IL-1	101,105	IL-1	44,48	IL-1	IL-1	3553	3553	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1 .
2107255	2	IL-1	44,48	IL-1	101,105	IL-1	IL-1	3553	3553	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1 .
2142008	0	IL-1	44,48	IL-1	98,102	IL-1	IL-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY modulation|nmod|receptor modulation|dep|antibody antibody|nmod|response response|nmod|END_ENTITY	In vivo modulation with anti-interleukin-1 -LRB- IL-1 -RRB- receptor -LRB- p80 -RRB- antibody 35F5 of the response to IL-1 .
2142008	0	IL-1	98,102	IL-1	44,48	IL-1	IL-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY antibody|nmod|response modulation|dep|antibody modulation|nmod|receptor receptor|appos|END_ENTITY	In vivo modulation with anti-interleukin-1 -LRB- IL-1 -RRB- receptor -LRB- p80 -RRB- antibody 35F5 of the response to IL-1 .
3131429	0	IL-1	0,4	IL-1	13,17	IL-1	IL-1	3553	3553	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	IL-1 induces IL-1 .
3131429	0	IL-1	13,17	IL-1	0,4	IL-1	IL-1	3553	3553	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	IL-1 induces IL-1 .
11640949	0	IL-1	65,69	IL-10	85,90	IL-1	IL-10	3553	3586	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Lack of association between human longevity and polymorphisms of IL-1 cluster , IL-6 , IL-10 and TNF-alpha genes in Finnish nonagenarians .
11723165	0	IL-1	43,47	IL-10	0,5	IL-1	IL-10	111343(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	IL-10 and IL-4 regulate type-I and type-II IL-1 receptors expression on IL-1_beta-activated mouse primary astrocytes .
9551930	0	IL-1	53,57	IL-10	23,28	IL-1	IL-10	3553	3586	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha : role of the p38 and p42/44 mitogen-activated protein kinases .
21169541	0	IL-1	30,34	IL-17	59,64	IL-1	IL-17	3552	3605	Gene	Gene	role|nmod|START_ENTITY role|nmod|response response|compound|END_ENTITY	Cutting edge : crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1 .1 - invariant NKT cells to bacteria .
23271701	0	IL-1	33,37	IL-17	49,54	IL-1	IL-17	3553	3605	Gene	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	The role of inflammasome-derived IL-1 in driving IL-17 responses .
23028054	0	IL-1	0,4	IL-18	20,25	IL-1	IL-18	3553	3606	Gene	Gene	members|compound|START_ENTITY members|amod|END_ENTITY	IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures .
25654981	0	IL-1	94,98	IL-1R8	121,127	IL-1	IL-1R8	111343(Tax:10090)	331461(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8 .
19046297	0	IL-1	15,19	IL-1Ra	8,14	IL-1	IL-1Ra	3552	3557	Gene	Gene	ratio|compound|START_ENTITY ratio|dep|END_ENTITY	Reduced IL-1Ra / IL-1 ratio in ultraviolet B-exposed skin of patients with polymorphic_light_eruption .
19258032	0	IL-1	0,4	IL-1ra	5,11	IL-1	IL-1ra	111343(Tax:10090)	16181(Tax:10090)	Gene	Gene	START_ENTITY|dep|balance balance|compound|END_ENTITY	IL-1 / IL-1ra balance in the brain revisited - evidence from transgenic mouse models .
10464704	0	IL-1	92,96	IL-2	39,43	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	cyclophosphamide|amod|START_ENTITY gene-modified|nmod|cyclophosphamide gene-modified|nsubj|responses responses|nmod|END_ENTITY	Enhanced antitumor immune responses of IL-2 gene-modified tumor vaccine by combination with IL-1 and low dose cyclophosphamide .
10479400	0	IL-1	97,101	IL-2	89,93	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	mitogen-activated|nmod|START_ENTITY mitogen-activated|nmod|induction induction|nmod|END_ENTITY	Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1 .
1309558	0	IL-1	48,52	IL-2	66,70	IL-1	IL-2	3553	3558	Gene	Gene	induction|compound|START_ENTITY induction|nmod|production production|compound|END_ENTITY	The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production .
1337985	0	IL-1	0,4	IL-2	18,22	IL-1	IL-2	3552	3558	Gene	Gene	synergy|compound|START_ENTITY synergy|nmod|END_ENTITY	IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-alpha and beta -LRB- lymphotoxin -RRB- .
1533149	0	IL-1	85,89	IL-2	111,115	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Similar co-stimulation requirements of CD4 + and CD8 + primary T helper cells : role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation .
1692959	0	IL-1	55,59	IL-2	74,78	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	A role for protein kinase C activity in interleukin-1 -LRB- IL-1 -RRB- induction of IL-2 gene expression but not in IL-1 signal transduction .
1699593	0	IL-1	0,4	IL-2	42,46	IL-1	IL-2	3552	3558	Gene	Gene	START_ENTITY|nmod|regulators regulators|nmod|induced induced|compound|END_ENTITY	IL-1 and IL-4 as reciprocal regulators of IL-2 induced lymphocyte cytotoxicity .
2424621	5	IL-1	810,814	IL-2	816,820	IL-1	IL-2	3552	3558	Gene	Gene	BCGF|compound|START_ENTITY BCGF|appos|END_ENTITY	The fraction of small B cells was incubated with IL-1 , IL-2 , Interferon-gamma , Interferon-alpha , BCGF , or BCDF , and cell size changes , RNA synthesis , DNA synthesis , or supernatant immunoglobulin -LRB- Ig -RRB- production were measured .
2466890	0	IL-1	83,87	IL-2	105,109	IL-1	IL-2	3552	3558	Gene	Gene	require|dobj|START_ENTITY require|nmod|secretion secretion|nmod|END_ENTITY	Helper-independent CD8 + cytotoxic T lymphocytes express IL-1 receptors and require IL-1 for secretion of IL-2 .
2786909	0	IL-1	0,4	IL-2	27,31	IL-1	IL-2	3552	3558	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-1 induces high affinity IL-2 receptor expression of CD4-8 - thymocytes .
2831272	0	IL-1	122,126	IL-2	21,25	IL-1	IL-2	3552	3558	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|Increased Increased|nmod|END_ENTITY	Increased binding of IL-2 and increased IL-2_receptor mRNA synthesis are expressed by an NK-like cell line in response to IL-1 .
2844906	0	IL-1	0,4	IL-2	19,23	IL-1	IL-2	3552	3558	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|production production|compound|END_ENTITY	IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis .
3097425	1	IL-1	75,79	IL-2	83,87	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|END_ENTITY	Comparison of the radioprotective effects of IL-1 to IL-2 , GM-CSF and IFN_gamma .
3115645	0	IL-1	46,50	IL-2	52,56	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	sodium_thiomalate|nmod|START_ENTITY effects|nmod|sodium_thiomalate responsiveness|nmod|effects responsiveness|nsubj|production production|compound|END_ENTITY	In vitro effects of gold sodium_thiomalate on IL-1 , IL-2 production , IL-2 receptor expression and IL-2 responsiveness in thymocytes and peripheral blood mononuclear cells .
6335676	0	IL-1	26,30	IL-2	51,55	IL-1	IL-2	3552	16183(Tax:10090)	Gene	Gene	interleukin-1|appos|START_ENTITY interleukin-1|appos|END_ENTITY	Effects of interleukin-1 -LRB- IL-1 -RRB- and interleukin-2 -LRB- IL-2 -RRB- on the in vivo growth and differentiation of progenitors of natural killer -LRB- NK -RRB- cells .
7506580	0	IL-1	202,206	IL-2	208,212	IL-1	IL-2	3552	3558	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
8820364	0	IL-1	0,4	IL-2	26,30	IL-1	IL-2	3552	3558	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	IL-1 and TNF-alpha but no IL-2 expression is found in squamous_cell_carcinomas of the head_and_neck by RT-PCR .
9130006	0	IL-1	141,145	IL-2	147,151	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	TNF|compound|START_ENTITY TNF|appos|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1 , IL-2 , IL-6 , TNF , CSF activity in normal mice .
9808178	0	IL-1	29,33	IL-2	85,89	IL-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY Effects|nmod|overexpression receptor-associated|nsubj|Effects receptor-associated|nmod|production production|dep|END_ENTITY	Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation , IL-2 production and stress-activated protein kinases in the murine T cell line EL4 .
11198376	0	IL-1	0,4	IL-4	6,10	IL-1	IL-4	3552	3565	Gene	Gene	production|compound|START_ENTITY production|dep|END_ENTITY	IL-1 , IL-4 production and IgE levels in acute and chronic fasciolosis before and after triclabendazole treatment .
1386862	0	IL-1	28,32	IL-4	0,4	IL-1	IL-4	3553	3565	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-4 reciprocally regulates IL-1 and IL-1_receptor_antagonist expression in human monocytes .
15178892	0	IL-1	30,34	IL-4	36,40	IL-1	IL-4	3552	3565	Gene	Gene	levels|nmod|START_ENTITY levels|appos|receptors receptors|compound|END_ENTITY	Altered levels of the soluble IL-1 , IL-4 and TNF receptors , as well as the IL-1_receptor_antagonist , in intermittent_allergic_rhinitis .
23608488	0	IL-1	19,23	IL-4	0,4	IL-1	IL-4	3553	3565	Gene	Gene	induced|amod|START_ENTITY expression|amod|induced inhibition|nmod|expression inhibition|compound|END_ENTITY	IL-4 inhibition of IL-1 induced Matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun_N-terminal_kinase -LRB- JNK -RRB- .
8332913	0	IL-1	51,55	IL-4	77,81	IL-1	IL-4	3552	3565	Gene	Gene	target|nmod|START_ENTITY target|acl:relcl|regulated regulated|nmod|END_ENTITY	Interleukin-1_type_II_receptor : a decoy target for IL-1 that is regulated by IL-4 .
9047078	0	IL-1	14,18	IL-4	119,123	IL-1	IL-4	3553	3565	Gene	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|nmod|END_ENTITY	Inhibition of IL-1 induced tissue factor -LRB- TF -RRB- synthesis and procoagulant_activity -LRB- PCA -RRB- in purified human monocytes by IL-4 , IL-10 and IL-13 .
9190949	0	IL-1	50,54	IL-4	135,139	IL-1	IL-4	3553	3565	Gene	Gene	antagonist|compound|START_ENTITY intracellular|dobj|antagonist type|acl:relcl|intracellular release|nmod|type release|dep|effects effects|nmod|END_ENTITY	Extracellular release of the type I intracellular IL-1 receptor antagonist from human airway epithelial cells : differential effects of IL-4 , IL-13 , IFN-gamma , and corticosteroids .
9632524	0	IL-1	62,66	IL-4	0,4	IL-1	IL-4	3552	3565	Gene	Gene	cells|amod|START_ENTITY rolling|nmod|cells downregulate|xcomp|rolling downregulate|nsubj|END_ENTITY	IL-4 and IL-13 downregulate rolling adhesion of leukocytes to IL-1 or TNF-alpha-activated endothelial cells by limiting the interval of E-selectin expression .
10201956	0	IL-1	23,27	IL-6	70,74	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|dobj|expression expression|acl|signaling signaling|nmod|END_ENTITY	Augmentation of type I IL-1 receptor expression and IL-1 signaling by IL-6 and glucocorticoid in murine hepatocytes .
10429944	0	IL-1	131,135	IL-6	11,15	IL-1	IL-6	3552	3569	Gene	Gene	comparison|nmod|START_ENTITY Effects|dep|comparison Effects|nmod|END_ENTITY	Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes : comparison with IL-1 .
10537140	0	IL-1	71,75	IL-6	85,89	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	interleukin-1|appos|START_ENTITY involved|nmod|interleukin-1 involved|dep|induced induced|dobj|synthesis synthesis|compound|END_ENTITY	Mitogen-activated protein -LRB- MAP -RRB- kinases are involved in interleukin-1 -LRB- IL-1 -RRB- - induced IL-6 synthesis in osteoblasts : modulation not of p38 MAP kinase , but of p42/p44 _ MAP_kinase by IL-1-activated protein kinase C .
11429163	0	IL-1	100,104	IL-6	170,174	IL-1	IL-6	3552	3569	Gene	Gene	effect|nmod|START_ENTITY contributes|nmod|effect contributes|advcl|augmenting augmenting|dobj|transcription transcription|nmod|END_ENTITY	CHOP , a basic leucine zipper transcriptional factor , contributes to the antiproliferative effect of IL-1 on A375 human melanoma cells through augmenting transcription of IL-6 .
11743653	0	IL-1	40,44	IL-6	46,50	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	roles|appos|START_ENTITY roles|appos|END_ENTITY	Discrete roles of cytokines , TNF-alpha , IL-1 , IL-6 in tumor promotion and cell transformation .
11780571	0	IL-1	31,35	IL-6	53,57	IL-1	IL-6	3552	3569	Gene	Gene	interleukin-1|appos|START_ENTITY interleukin-1|amod|interleukin-6 interleukin-6|dep|END_ENTITY	Serum levels of interleukin-1 -LRB- IL-1 -RRB- , interleukin-6 -LRB- IL-6 -RRB- and interleukin-8 -LRB- IL-8 -RRB- in patients treated with dental implants .
11859379	0	IL-1	42,46	IL-6	60,64	IL-1	IL-6	3552	3569	Gene	Gene	Induction|compound|START_ENTITY Induction|nmod|END_ENTITY	Evidence of an Eicosanoid Contribution to IL-1 Induction of IL-6 in Human Articular Chondrocytes .
1330001	0	IL-1	42,46	IL-6	17,21	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	The induction of IL-6 and gelatinase_B by IL-1 in mouse cell lines transformed with bovine papillomavirus : decreased production in tumorigenic cells .
1350224	0	IL-1	59,63	IL-6	83,87	IL-1	IL-6	3552	3569	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Characterization of thymic cell subpopulations involved in IL-1 - or GM-CSF-induced IL-6 production .
14568962	0	IL-1	0,4	IL-6	36,40	IL-1	IL-6	3552	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells .
1626472	0	IL-1	75,79	IL-6	125,129	IL-1	IL-6	3552	3569	Gene	Gene	interleukin|appos|START_ENTITY cells|dep|interleukin -LSB-|nmod|cells -LSB-|dep|interleukin interleukin|appos|END_ENTITY	-LSB- The synthesis of cytokines by human lens epithelial cells -- interleukin 1 -LRB- IL-1 -RRB- , tumor necrosis factor -LRB- TNF -RRB- interleukin 6 -LRB- IL-6 -RRB- , and epidermal_growth_factor -LRB- EGF -RRB- -RSB- .
1651782	0	IL-1	14,18	IL-6	67,71	IL-1	IL-6	3553	3569	Gene	Gene	properties|compound|START_ENTITY Modulation|nmod|properties Modulation|nmod|END_ENTITY	Modulation of IL-1 inflammatory and immunomodulatory properties by IL-6 .
1727866	0	IL-1	16,20	IL-6	0,4	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite .
1906383	0	IL-1	192,196	IL-6	151,155	IL-1	IL-6	3552	3569	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- , tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes .
1932368	0	IL-1	35,39	IL-6	73,77	IL-1	IL-6	3552	3569	Gene	Gene	interleukin-1_beta|appos|START_ENTITY release|nmod|interleukin-1_beta precedes|nsubj|release precedes|dobj|that that|nmod|interleukin_6 interleukin_6|appos|END_ENTITY	The release of interleukin-1_beta -LRB- IL-1 -RRB- precedes that of interleukin_6 -LRB- IL-6 -RRB- in patients undergoing major surgery .
1997513	0	IL-1	35,39	IL-6	110,114	IL-1	IL-6	3552	3569	Gene	Gene	interleukin-1|appos|START_ENTITY stimulates|nsubj|interleukin-1 stimulates|advcl|activating activating|dobj|system system|amod|END_ENTITY	Trophoblast-derived interleukin-1 -LRB- IL-1 -RRB- stimulates the release of human chorionic gonadotropin by activating IL-6 and IL-6-receptor system in first trimester human trophoblasts .
2056245	0	IL-1	74,78	IL-6	80,84	IL-1	IL-6	3553	3569	Gene	Gene	TNF-alpha|compound|START_ENTITY TNF-alpha|appos|END_ENTITY	Developmental regulation of the cytokine repertoire in human macrophages : IL-1 , IL-6 , TNF-alpha , and M-CSF .
2070556	0	IL-1	32,36	IL-6	49,53	IL-1	IL-6	3553	3569	Gene	Gene	increase|nmod|START_ENTITY inhibitors|nsubj|increase inhibitors|dep|END_ENTITY	Selective and early increase of IL-1 inhibitors , IL-6 and cortisol after elective surgery .
21178846	0	IL-1	97,101	IL-6	38,42	IL-1	IL-6	3553	3569	Gene	Gene	react|nmod|START_ENTITY react|nmod|END_ENTITY	Human nucleus pulposus cells react to IL-6 : independent actions and amplification of response to IL-1 and TNF-a .
2265243	0	IL-1	61,65	IL-6	75,79	IL-1	IL-6	3552	3569	Gene	Gene	START_ENTITY|acl|induced induced|dobj|production production|compound|END_ENTITY	Transforming_growth_factor_beta downregulates interleukin-1 -LRB- IL-1 -RRB- - induced IL-6 production by human monocytes .
2294996	0	IL-1	161,165	IL-6	145,149	IL-1	IL-6	3553	3569	Gene	Gene	suppresses|dep|START_ENTITY suppresses|compound|END_ENTITY	Correlations and interactions in the production of interleukin-6 -LRB- IL-6 -RRB- , IL-1 , and tumor_necrosis_factor -LRB- TNF -RRB- in human blood mononuclear cells : IL-6 suppresses IL-1 and TNF .
2294996	0	IL-1	161,165	IL-6	66,70	IL-1	IL-6	3553	3569	Gene	Gene	suppresses|dep|START_ENTITY Correlations|dep|suppresses Correlations|nmod|production production|nmod|END_ENTITY	Correlations and interactions in the production of interleukin-6 -LRB- IL-6 -RRB- , IL-1 , and tumor_necrosis_factor -LRB- TNF -RRB- in human blood mononuclear cells : IL-6 suppresses IL-1 and TNF .
2341718	0	IL-1	109,113	IL-6	0,4	IL-1	IL-6	3553	3569	Gene	Gene	release|compound|START_ENTITY inducing|dobj|release stimulates|advcl|inducing stimulates|nsubj|END_ENTITY	IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow_cultures by inducing IL-1 release .
2358670	0	IL-1	0,4	IL-6	68,72	IL-1	IL-6	3552	3569	Gene	Gene	necrosis|nsubj|START_ENTITY necrosis|ccomp|stimulate stimulate|dobj|production production|compound|END_ENTITY	IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA .
26448147	0	IL-1	40,44	IL-6	15,19	IL-1	IL-6	3552	3569	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|END_ENTITY	Muscle-Derived IL-6 Is Not Regulated by IL-1 during Exercise .
26945843	0	IL-1	70,74	IL-6	75,79	IL-1	IL-6	3552	3569	Gene	Gene	successful|nmod|START_ENTITY indicates|dobj|successful axis|dep|indicates axis|compound|END_ENTITY	Reduction in C-reactive_protein indicates successful targeting of the IL-1 / IL-6 axis resulting in improved survival in early stage multiple_myeloma .
2783442	0	IL-1	0,4	IL-6	16,20	IL-1	IL-6	3553	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	IL-1 stimulates IL-6 production in endothelial cells .
2789259	0	IL-1	29,33	IL-6	0,4	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	IL-6 is a potent cofactor of IL-1 in IgM synthesis and of IL-5 in IgA synthesis .
3265677	0	IL-1	161,165	IL-6	57,61	IL-1	IL-6	3553	3569	Gene	Gene	assays|nmod|START_ENTITY use|nmod|assays Induction|dep|use Induction|amod|END_ENTITY	Induction of hybridoma_growth_factor -LRB- HGF -RRB- , identical to IL-6 , in human fibroblasts by IL-1 : use of HGF activity in specific and sensitive biological assays for IL-1 and IL-6 .
3265677	0	IL-1	87,91	IL-6	57,61	IL-1	IL-6	3553	3569	Gene	Gene	fibroblasts|nmod|START_ENTITY Induction|nmod|fibroblasts Induction|amod|END_ENTITY	Induction of hybridoma_growth_factor -LRB- HGF -RRB- , identical to IL-6 , in human fibroblasts by IL-1 : use of HGF activity in specific and sensitive biological assays for IL-1 and IL-6 .
7561064	0	IL-1	16,20	IL-6	54,58	IL-1	IL-6	3552	3569	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|production production|compound|END_ENTITY	Contribution of IL-1 , CD14 , and CD13 in the increased IL-6 production induced by in vitro monocyte-synoviocyte interactions .
7752112	0	IL-1	103,107	IL-6	49,53	IL-1	IL-6	3553	3569	Gene	Gene	mediated|amod|START_ENTITY process|amod|mediated process|nsubj|Synthesis Synthesis|appos|END_ENTITY	Synthesis of metalloproteases and interleukin_6 -LRB- IL-6 -RRB- in human osteoarthritic synovial membrane is an IL-1 mediated process .
7928300	0	IL-1	30,34	IL-6	37,41	IL-1	IL-6	3553	3569	Gene	Gene	interleukin|appos|START_ENTITY interleukin|appos|production production|compound|END_ENTITY	Differences in interleukin 1 -LRB- IL-1 -RRB- , IL-6 , tumor_necrosis_factor and IL-1_receptor_antagonist production by human monocytes stimulated with muramyl_dipeptide -LRB- MDP -RRB- and its stearoyl derivative , romurtide .
8473513	0	IL-1	73,77	IL-6	31,35	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|production production|compound|END_ENTITY	IL-1-induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 _ dihydroxyvitamin_D3 .
8742063	0	IL-1	34,38	IL-6	43,47	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|activities activities|compound|END_ENTITY	Complementary organ expression of IL-1 vs. IL-6 and CSF-1 activities in normal and LPS-injected mice .
8897812	0	IL-1	99,103	IL-6	13,17	IL-1	IL-6	3552	3569	Gene	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|compound|END_ENTITY	ET-1 induces IL-6 gene expression in human umbilical vein endothelial cells : synergistic effect of IL-1 .
9130006	0	IL-1	141,145	IL-6	153,157	IL-1	IL-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	TNF|compound|START_ENTITY TNF|appos|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1 , IL-2 , IL-6 , TNF , CSF activity in normal mice .
9575340	0	IL-1	8,12	IL-6	49,53	IL-1	IL-6	3553	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis .
15259026	0	IL-1	93,97	IL-8	0,4	IL-1	IL-8	3553	3576	Gene	Gene	production|compound|START_ENTITY LPS|nmod|production synergism|nmod|LPS induces|parataxis|synergism induces|nsubj|END_ENTITY	IL-8 induces a specific transcriptional profile in human neutrophils : synergism with LPS for IL-1 production .
1532945	0	IL-1	15,19	IL-8	93,97	IL-1	IL-8	3553	3576	Gene	Gene	reduces|dep|START_ENTITY reduces|dobj|synthesis synthesis|compound|END_ENTITY	Interleukin-1 -LRB- IL-1 -RRB- receptor blockade reduces endotoxin and Borrelia_burgdorferi-stimulated IL-8 synthesis in human mononuclear cells .
1937574	0	IL-1	0,4	IL-8	32,36	IL-1	IL-8	3552	3576	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	IL-1 and TNF-alpha induction of IL-8 and monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- mRNA expression in a human astrocytoma cell line .
9164965	0	IL-1	58,62	IL-8	89,93	IL-1	IL-8	3552	3576	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Thrombin induces endothelial type II activation in vitro : IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression .
15905496	0	IL-1	28,32	IRAK-4	63,69	IL-1	IRAK-4	3552	51135	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Cutting edge : expression of IL-1 receptor-associated kinase-4 -LRB- IRAK-4 -RRB- proteins with mutations identified in a patient with recurrent bacterial_infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex .
15574499	0	IL-1	68,72	IkappaB_kinase_beta	0,19	IL-1	IkappaB kinase beta	3553	3551	Gene	Gene	phosphorylates|nmod|START_ENTITY phosphorylates|nsubj|END_ENTITY	IkappaB_kinase_beta phosphorylates Dok1 serines in response to TNF , IL-1 , or gamma radiation .
1533794	0	IL-1	15,19	Interleukin-1	0,13	IL-1	Interleukin-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Interleukin-1 -LRB- IL-1 -RRB- receptors on murine splenic B cells and the 70Z/3 pre-B-cell line appear to be identical and bind human IL-1_alpha and IL-1_beta differentially .
2138628	0	IL-1	15,19	Interleukin-1	0,13	IL-1	Interleukin-1	3552	3552	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Interleukin-1 -LRB- IL-1 -RRB- regulation of human endometrial function : presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin_E2 production .
8332913	0	IL-1	51,55	Interleukin-1_type_II_receptor	0,30	IL-1	Interleukin-1 type II receptor	3552	7850	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Interleukin-1_type_II_receptor : a decoy target for IL-1 that is regulated by IL-4 .
7521369	0	IL-1	149,153	NF-kappa_B	14,24	IL-1	NF-kappa B	3552	4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of NF-kappa_B and induction of vascular_cell_adhesion_molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1 .
3263853	0	IL-1	32,36	THP-1	90,95	IL-1	THP-1	3553	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Post-transcriptional control of IL-1 gene expression in the acute_monocytic_leukemia line THP-1 .
10528210	0	IL-1	0,4	TNF-alpha	119,128	IL-1	TNF-alpha	111343(Tax:10090)	21926(Tax:10090)	Gene	Gene	alpha|dep|START_ENTITY blockade|amod|alpha prevents|nsubj|blockade prevents|advcl|ameliorates ameliorates|nsubj|blockade blockade|amod|END_ENTITY	IL-1 alpha beta blockade prevents cartilage and bone_destruction in murine type II collagen-induced arthritis , whereas TNF-alpha blockade only ameliorates joint inflammation .
11673538	0	IL-1	55,59	TNF-alpha	0,9	IL-1	TNF-alpha	111343(Tax:10090)	21926(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY defense|nmod|mice compensates|nmod|defense compensates|nsubj|END_ENTITY	TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal_pneumonia .
11743653	0	IL-1	40,44	TNF-alpha	29,38	IL-1	TNF-alpha	111343(Tax:10090)	21926(Tax:10090)	Gene	Gene	roles|appos|START_ENTITY roles|appos|END_ENTITY	Discrete roles of cytokines , TNF-alpha , IL-1 , IL-6 in tumor promotion and cell transformation .
11895541	0	IL-1	53,57	TNF-alpha	58,67	IL-1	TNF-alpha	3552	7124	Gene	Gene	assessment|nmod|START_ENTITY assessment|dep|inhibition inhibition|amod|END_ENTITY	Clinical , radiographic and biochemical assessment of IL-1 / TNF-alpha antagonist inhibition of bone_loss in experimental periodontitis .
12235693	0	IL-1	82,86	TNF-alpha	119,128	IL-1	TNF-alpha	3552	7124	Gene	Gene	factor|compound|START_ENTITY factor|acl|END_ENTITY	-LSB- Effect of antibiotic therapy on levels of proinflammatory cytokines : interleukin IL-1 , IL-6 and tumor necrosis factor TNF-alpha in serum of patients with Lyme_borreliosis -RSB- .
1337985	0	IL-1	0,4	TNF-alpha	93,102	IL-1	TNF-alpha	3552	7124	Gene	Gene	synergy|compound|START_ENTITY mediated|nsubjpass|synergy mediated|nmod|lymphotoxin lymphotoxin|compound|END_ENTITY	IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-alpha and beta -LRB- lymphotoxin -RRB- .
16365459	0	IL-1	109,113	TNF-alpha	114,123	IL-1	TNF-alpha	3552	7124	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1 / TNF-alpha production .
17703191	0	IL-1	61,65	TNF-alpha	49,58	IL-1	TNF-alpha	111343(Tax:10090)	21926(Tax:10090)	Gene	Gene	termination|amod|START_ENTITY termination|nmod|END_ENTITY	Essential role for TAX1BP1 in the termination of TNF-alpha - , IL-1 - and LPS-mediated NF-kappaB and JNK signaling .
1906501	0	IL-1	49,53	TNF-alpha	54,63	IL-1	TNF-alpha	3553	7124	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	An NF-kappa_B-like transcription factor mediates IL-1 / TNF-alpha induction of gro in human fibroblasts .
8175024	0	IL-1	152,156	TNF-alpha	71,80	IL-1	TNF-alpha	3552	7124	Gene	Gene	_|appos|START_ENTITY response|nmod|_ abolishes|dobj|response antisense|ccomp|abolishes antisense|nsubj|Transfection Transfection|appos|END_ENTITY	Transfection of ovarian_cancer cells with tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- antisense mRNA abolishes the proliferative response to interleukin-1 _ -LRB- IL-1 -RRB- but not TNF-alpha .
9103454	0	IL-1	91,95	TNF-alpha	0,9	IL-1	TNF-alpha	3553	7124	Gene	Gene	type|dep|START_ENTITY receptor|amod|type release|nmod|receptor induces|dobj|release induces|advmod|END_ENTITY	TNF-alpha , unlike other pro- and anti-inflammatory cytokines , induces rapid release of the IL-1 type II decoy receptor in human myelomonocytic cells .
1893406	0	IL-1	35,39	TNF_alpha	24,33	IL-1	TNF alpha	111343(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Induction of macrophage TNF_alpha , IL-1 , IL-6 , and PGE2 production by DTH-initiating factors .
1993554	0	IL-1	221,225	TNF_alpha	254,263	IL-1	TNF alpha	3552	7124	Gene	Gene	interleukin-1|appos|START_ENTITY interleukin-1|appos|END_ENTITY	Growth regulation of the AML-193 leukemic cell line : evidence for autocrine production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , and inhibition of GM-CSF-dependent cell proliferation by interleukin-1 -LRB- IL-1 -RRB- and tumor necrosis factor -LRB- TNF_alpha -RRB- .
11418661	0	IL-1	0,4	TNF_receptor-associated_factor-6	70,102	IL-1	TNF receptor-associated factor-6	3552	222344	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	IL-1 induced chemokine production through the association of Syk with TNF_receptor-associated_factor-6 in nasal fibroblast lines .
17967442	0	IL-1	66,70	TNFalpha	11,19	IL-1	TNFalpha	111343(Tax:10090)	21926(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Peripheral TNFalpha , but not peripheral IL-1 , requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response .
10882101	0	IL-1	98,102	TRAF6	85,90	IL-1	TRAF6	3552	7189	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	TAB2 , a novel adaptor protein , mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway .
12496252	0	IL-1	41,45	TRAF6	198,203	IL-1	TRAF6	3552	7189	Gene	Gene	interleukin-1|appos|START_ENTITY required|nmod|interleukin-1 required|dep|IRAK-tumor_necrosis_factor_receptor-associated_factor_6 IRAK-tumor_necrosis_factor_receptor-associated_factor_6|xcomp|complex complex|dep|END_ENTITY	Pellino_1 is required for interleukin-1 -LRB- IL-1 -RRB- - mediated signaling through its interaction with the IL-1_receptor-associated_kinase_4 -LRB- IRAK4 -RRB- - IRAK-tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- complex .
16371247	0	IL-1	58,62	TRAF6	0,5	IL-1	TRAF6	3552	7189	Gene	Gene	regulates|nmod|START_ENTITY kinase|ccomp|regulates kinase|nsubj|END_ENTITY	TRAF6 and Src kinase activity regulates Cot activation by IL-1 .
18950704	0	IL-1	16,20	TRAF6	72,77	IL-1	TRAF6	3553	7189	Gene	Gene	IKK|compound|START_ENTITY IKK|acl|activation activation|advcl|interacting interacting|nmod|END_ENTITY	HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination .
2265243	0	IL-1	61,65	Transforming_growth_factor_beta	0,31	IL-1	Transforming growth factor beta	3552	7040	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Transforming_growth_factor_beta downregulates interleukin-1 -LRB- IL-1 -RRB- - induced IL-6 production by human monocytes .
20713887	0	IL-1	27,31	Tyrosine_kinase_2	0,17	IL-1	Tyrosine kinase 2	111343(Tax:10090)	54721(Tax:10090)	Gene	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	Tyrosine_kinase_2 controls IL-1 production at the translational level .
1630052	0	IL-1	71,75	alpha_1_protease_inhibitor	23,49	IL-1	alpha 1 protease inhibitor	3553	5265	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	-LSB- Inhibitory effects of alpha_1_protease_inhibitor on the production of IL-1 and TNF_alpha by alveolar macrophages in patients with lung_cancer -RSB- .
24565903	0	IL-1	0,4	aryl_hydrocarbon_receptor	29,54	IL-1	aryl hydrocarbon receptor	3553	196	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	IL-1 and TNF-a regulation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in HSY human salivary cells .
8264864	0	IL-1	47,51	corticotropin-releasing_factor	70,100	IL-1	corticotropin-releasing factor	3552	1392	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Alpha-melanocyte-stimulating_hormone abolishes IL-1 - and IL-6-induced corticotropin-releasing_factor release from the hypothalamus in vitro .
16283110	0	IL-1	17,21	iNOS	31,35	IL-1	iNOS	3553	4843	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	TGFbeta inhibits IL-1 - induced iNOS expression and NO production in immortalized chondrocytes .
1280480	0	IL-1	161,165	interleukin-1	146,159	IL-1	interleukin-1	3552	3552	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Human peritoneal mesothelial cells produce many cytokines -LRB- granulocyte colony-stimulating factor -LSB- CSF -RSB- , granulocyte-monocyte-CSF , macrophage-CSF , interleukin-1 -LSB- IL-1 -RSB- , and IL-6 -RRB- and are activated and stimulated to grow by IL-1 .
1312652	0	IL-1	26,30	interleukin-1	11,24	IL-1	interleukin-1	3552	3552	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin-1 -LRB- IL-1 -RRB- on postsurgical macrophage secretion of protease and protease inhibitor activities .
1692959	0	IL-1	55,59	interleukin-1	40,53	IL-1	interleukin-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	A role for protein kinase C activity in interleukin-1 -LRB- IL-1 -RRB- induction of IL-2 gene expression but not in IL-1 signal transduction .
2505890	0	IL-1	152,156	interleukin-1	137,150	IL-1	interleukin-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of hematopoietic_growth_factor -LRB- GM-CSF : granulocyte-macrophage_colony-stimulating_factor -RRB- on thymocyte proliferation induced by interleukin-1 -LRB- IL-1 -RRB- -RSB- .
2509011	0	IL-1	38,42	interleukin-1	23,36	IL-1	interleukin-1	3552	3552	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Spontaneous release of interleukin-1 -LRB- IL-1 -RRB- from medullary mononuclear cells of pagetic subjects .
2981169	0	IL-1	116,120	interleukin-1	101,114	IL-1	interleukin-1	3552	3552	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Modulation of the sodium_periodate -LRB- NaIO4 -RRB- response in systemic_lupus_erythematosus -LRB- SLE -RRB- : effect of interleukin-1 -LRB- IL-1 -RRB- , interleukin-2 -LRB- IL-2 -RRB- , phorbol_myristate_acetate -LRB- PMA -RRB- , and indomethacin .
7622454	0	IL-1	58,62	interleukin-1	25,38	IL-1	interleukin-1	3552	3552	Gene	Gene	activity|compound|START_ENTITY requires|dobj|activity requires|nsubj|activation activation|nmod|END_ENTITY	NF-kappa_B activation by interleukin-1 -LRB- IL-1 -RRB- requires an IL-1 receptor-associated protein kinase activity .
8783045	0	IL-1	29,33	interleukin-1	14,27	IL-1	interleukin-1	3552	3552	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of interleukin-1 -LRB- IL-1 -RRB- on androgen metabolism in human gingival tissue -LRB- HGT -RRB- and periodontal ligament -LRB- PDL -RRB- .
3493098	0	IL-1	42,46	interleukin_1	27,40	IL-1	interleukin 1	3552	3552	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Increased production of an interleukin_1 -LRB- IL-1 -RRB- inhibitor with fibroblast stimulating activity by mononuclear cells from patients with scleroderma .
8131658	0	IL-1	96,100	interleukin_1	81,94	IL-1	interleukin 1	3552	3552	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The influence of Chinese traditional medicine on the production and activity of interleukin_1 -LRB- IL-1 -RRB- -RSB- .
10820228	0	IL-1	133,137	kit_ligand	103,113	IL-1	kit ligand	111343(Tax:10090)	17311(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Murine bone marrow-derived mast cells as potent producers of IL-9 : costimulatory function of IL-10 and kit_ligand in the presence of IL-1 .
11698482	0	IL-1	20,24	macrophage_inflammatory_protein-3alpha	50,88	IL-1	macrophage inflammatory protein-3alpha	3553	6364	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Enhancing effect of IL-1 , IL-17 , and TNF-alpha on macrophage_inflammatory_protein-3alpha production in rheumatoid_arthritis : regulation by soluble receptors and Th2 cytokines .
1993840	0	IL-1	0,4	ornithine_decarboxylase	13,36	IL-1	ornithine decarboxylase	3552	4953	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-1 induces ornithine_decarboxylase in normal T lymphocytes .
2971724	0	IL-1	68,72	ornithine_decarboxylase	8,31	IL-1	ornithine decarboxylase	3552	4953	Gene	Gene	factor|compound|START_ENTITY Role|nmod|factor Role|nmod|END_ENTITY	Role of ornithine_decarboxylase in the regulation of cell growth by IL-1 and tumor necrosis factor .
3501508	0	IL-1	38,42	ornithine_decarboxylase	92,115	IL-1	ornithine decarboxylase	111343(Tax:10090)	18263(Tax:10090)	Gene	Gene	sensitive|appos|START_ENTITY Identification|nmod|sensitive organs|nsubj|Identification organs|nmod|vivo vivo|acl|using using|dobj|induction induction|nmod|END_ENTITY	Identification of some interleukin-1 -LRB- IL-1 -RRB- sensitive organs in vivo using the induction of ornithine_decarboxylase -LRB- ODC -RRB- following injection of recombinant IL-1_beta in mice .
10788799	0	IL-1	0,4	p21	27,30	IL-1	p21	3553	1026	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IL-1 induces expression of p21 -LRB- WAF1 -RRB- independently of p53 in high-passage human embryonic fibroblasts WI38 .
2142008	0	IL-1	44,48	p80	60,63	IL-1	p80	111343(Tax:10090)	12812(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	In vivo modulation with anti-interleukin-1 -LRB- IL-1 -RRB- receptor -LRB- p80 -RRB- antibody 35F5 of the response to IL-1 .
2142008	0	IL-1	98,102	p80	60,63	IL-1	p80	111343(Tax:10090)	12812(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY antibody|nmod|response modulation|dep|antibody modulation|nmod|receptor receptor|appos|END_ENTITY	In vivo modulation with anti-interleukin-1 -LRB- IL-1 -RRB- receptor -LRB- p80 -RRB- antibody 35F5 of the response to IL-1 .
16914534	0	IL-1	0,4	plasminogen_activator_inhibitor-1	32,65	IL-1	plasminogen activator inhibitor-1	111343(Tax:10090)	18787(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	IL-1 and IL-6 induce hepatocyte plasminogen_activator_inhibitor-1 expression through independent signaling pathways converging on C/EBPdelta .
2201834	0	IL-1	114,118	tumor_necrosis_factor-alpha	141,168	IL-1	tumor necrosis factor-alpha	3552	7124	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Hemopoietin-1 activity of interleukin-1 -LRB- IL-1 -RRB- on acute_myeloid_leukemia colony-forming cells -LRB- AML-CFU -RRB- in vitro : IL-1 induces production of tumor_necrosis_factor-alpha which synergizes with IL-3 or granulocyte-macrophage_colony-stimulating_factor .
2201834	0	IL-1	41,45	tumor_necrosis_factor-alpha	141,168	IL-1	tumor necrosis factor-alpha	3552	7124	Gene	Gene	activity|nmod|START_ENTITY activity|dep|production production|nmod|END_ENTITY	Hemopoietin-1 activity of interleukin-1 -LRB- IL-1 -RRB- on acute_myeloid_leukemia colony-forming cells -LRB- AML-CFU -RRB- in vitro : IL-1 induces production of tumor_necrosis_factor-alpha which synergizes with IL-3 or granulocyte-macrophage_colony-stimulating_factor .
8175024	0	IL-1	152,156	tumor_necrosis_factor-alpha	42,69	IL-1	tumor necrosis factor-alpha	3552	7124	Gene	Gene	_|appos|START_ENTITY response|nmod|_ abolishes|dobj|response antisense|ccomp|abolishes antisense|nsubj|Transfection Transfection|nmod|cells cells|nmod|END_ENTITY	Transfection of ovarian_cancer cells with tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- antisense mRNA abolishes the proliferative response to interleukin-1 _ -LRB- IL-1 -RRB- but not TNF-alpha .
8889469	0	IL-1	27,31	tumor_necrosis_factor-alpha	87,114	IL-1	tumor necrosis factor-alpha	3553	7124	Gene	Gene	regulation|nmod|START_ENTITY keratinocytes|nsubj|regulation keratinocytes|nmod|END_ENTITY	Differential regulation of IL-1 and IL-1_receptor_antagonist in HaCaT keratinocytes by tumor_necrosis_factor-alpha and transforming_growth_factor-beta_1 .
9698257	0	IL-1-alpha	0,10	CD4	49,52	IL-1-alpha	CD4	16175(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	IL-1-alpha and TNF-alpha differentially regulate CD4 and Mac-1 expression in mouse microglia .
1436241	0	IL-1-alpha	32,42	IFN-alpha	10,19	IL-1-alpha	IFN-alpha	3552	3439	Gene	Gene	TNF-alpha|compound|START_ENTITY END_ENTITY|dep|TNF-alpha	Cytokine -LRB- IFN-alpha , IFN-gamma , IL-1-alpha , TNF-alpha -RRB- - induced modulation of HLA cell surface expression in human breast_cancer cell lines .
17166728	0	IL-1-beta	62,71	Cyclooxygenase-2	0,16	IL-1-beta	Cyclooxygenase-2	16176(Tax:10090)	19225(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Cyclooxygenase-2 mediates the sensitizing effects of systemic IL-1-beta on excitotoxic brain_lesions in newborn mice .
8552986	0	IL-1-beta	99,108	IL-10	130,135	IL-1-beta	IL-10	3553	3586	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1-beta	99,108	IL-1RA	110,116	IL-1-beta	IL-1RA	3553	3557	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
21173731	0	IL-1-beta	17,26	IL-6	0,4	IL-1-beta	IL-6	3553	3569	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	IL-6 , TNF-alpha , IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions .
8552986	0	IL-1-beta	99,108	IL-6	118,122	IL-1-beta	IL-6	3553	3569	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1-beta	99,108	IL-8	124,128	IL-1-beta	IL-8	3553	3576	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1-beta	99,108	TGF_beta	137,145	IL-1-beta	TGF beta	3553	7040	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
21173731	0	IL-1-beta	17,26	TNF-alpha	6,15	IL-1-beta	TNF-alpha	3553	7124	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	IL-6 , TNF-alpha , IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions .
8552986	0	IL-1-beta	99,108	TNF_alpha	147,156	IL-1-beta	TNF alpha	3553	7124	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
25381386	0	IL-10	0,5	Aicda	16,21	IL-10	Aicda	3586	57379	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-10 regulates Aicda expression through miR-155 .
21949832	0	IL-10	14,19	Akt	0,3	IL-10	Akt	25325(Tax:10116)	24185(Tax:10116)	Gene	Gene	suppression|compound|START_ENTITY regulates|dobj|suppression regulates|nsubj|END_ENTITY	Akt regulates IL-10 mediated suppression of TNFa-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation .
16259956	0	IL-10	27,32	Apolipoprotein_A-I	0,18	IL-10	Apolipoprotein A-I	3586	335	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Apolipoprotein_A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation .
23128494	0	IL-10	78,83	B7-H3	0,5	IL-10	B7-H3	3586	80381	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	B7-H3 expression in ductal and lobular breast_cancer and its association with IL-10 .
7722292	0	IL-10	12,17	B_cell_activation	27,44	IL-10	B cell activation	3586	29760	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of IL-10 in human B_cell_activation , proliferation , and differentiation .
21221124	0	IL-10	49,54	Bmi1	23,27	IL-10	Bmi1	3586	648	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Polycomb group protein Bmi1 negatively regulates IL-10 expression in activated macrophages .
18957080	0	IL-10	48,53	Bv8	34,37	IL-10	Bv8	16153(Tax:10090)	50501(Tax:10090)	Gene	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	The prokineticin receptor agonist Bv8 decreases IL-10 and IL-4 production in mice splenocytes by activating prokineticin_receptor-1 .
21106540	0	IL-10	25,30	C5a	0,3	IL-10	C5a	16153(Tax:10090)	15139(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase .
24656930	0	IL-10	0,5	CCL5	19,23	IL-10	CCL5	25325(Tax:10116)	81780(Tax:10116)	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats .
25971630	0	IL-10	17,22	CCL5	0,4	IL-10	CCL5	25325(Tax:10116)	81780(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	CCL5 upregulates IL-10 expression and partially mediates the antihypertensive effects of IL-10 in the vascular smooth muscle cells of spontaneously hypertensive rats .
12711332	0	IL-10	0,5	CCR1	46,50	IL-10	CCR1	3586	1230	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	IL-10 synergistically enhances GM-CSF-induced CCR1 expression in myelomonocytic cells .
19196047	0	IL-10	10,15	CCR2	56,60	IL-10	CCR2	3586	729230	Gene	Gene	Cytokine|dep|START_ENTITY Cytokine|dep|END_ENTITY	Cytokine -LRB- IL-10 -1082 and -819 -RRB- and chemokine_receptor -LRB- CCR2 and CCR5 -RRB- gene polymorphism in North Indian patients with end-stage_renal_disease .
10392758	0	IL-10	0,5	CCR5	19,23	IL-10	CCR5	3586	1234	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	IL-10 up-regulates CCR5 gene expression in human monocytes .
11698430	0	IL-10	0,5	CCR6	14,18	IL-10	CCR6	3586	1235	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-gamma suppress it .
15579430	0	IL-10	29,34	CD1	50,53	IL-10	CD1	3586	910	Gene	Gene	molecules|compound|START_ENTITY molecules|compound|END_ENTITY	Metastatic_melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic_tumor lesions .
22547651	0	IL-10	62,67	CD141	9,14	IL-10	CD141	3586	7056	Gene	Gene	produce|dobj|START_ENTITY +|ccomp|produce +|nsubj|END_ENTITY	Resident CD141 -LRB- BDCA3 -RRB- + dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin_inflammation .
25326368	0	IL-10	142,147	CD210	148,153	IL-10	CD210	3586	3587	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	Bone Marrow Mesenchymal Stromal Cells Induce Proliferative , Cytokinic and Molecular Changes During the T Cell Response : The Importance of the IL-10 / CD210 Axis .
11207250	0	IL-10	94,99	CD25	0,4	IL-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY regulate|nmod|production +|ccomp|regulate +|nsubj|CD4 CD4|compound|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11809742	0	IL-10	114,119	CD25	12,16	IL-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Natural CD4 CD25 -LRB- + -RRB- regulatory T cells control the burst of superantigen-induced cytokine production : the role of IL-10 .
12609834	0	IL-10	0,5	CD25	43,47	IL-10	CD25	3586	3559	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	IL-10 and TGF-beta induce alloreactive CD4 + CD25 - T cells to acquire regulatory cell function .
12928371	0	IL-10	27,32	CD25	45,49	IL-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY induces|nsubj|overexpression induces|dobj|populations populations|compound|END_ENTITY	Systemic overexpression of IL-10 induces CD4 + CD25 + cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion .
14519757	0	IL-10	52,57	CD25	97,101	IL-10	CD25	3586	3559	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|+ +|compound|END_ENTITY	The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4 + CD25 + and CD8 + regulatory T cell subsets .
14734610	0	IL-10	0,5	CD25	85,89	IL-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|cells cells|compound|END_ENTITY	IL-10 is involved in the suppression of experimental_autoimmune_encephalomyelitis by CD25 + CD4 + regulatory T cells .
16622000	0	IL-10	16,21	CD25	61,65	IL-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY independent|nsubj|cells independent|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Antigen-induced IL-10 + regulatory T cells are independent of CD25 + regulatory cells for their growth , differentiation , and function .
17389235	0	IL-10	24,29	CD25	64,68	IL-10	CD25	3586	3559	Gene	Gene	mRNA|compound|START_ENTITY accumulation|nmod|mRNA accumulation|dep|cells cells|amod|distinct distinct|nmod|+ +|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17990114	0	IL-10	82,87	CD25	4,8	IL-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY intestinal_inflammation|nmod|mice have|nmod|intestinal_inflammation have|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells have divergent effects on intestinal_inflammation in IL-10 gene-deficient mice .
19849943	0	IL-10	42,47	CD25	16,20	IL-10	CD25	3586	3559	Gene	Gene	levels|amod|START_ENTITY cells|appos|levels +|dobj|cells +|nsubj|Changes Changes|nmod|END_ENTITY	-LSB- Changes of CD4 + CD25 + regulatory T cells , IL-10 and TGF-beta1 levels in peripheral blood in children with asthma -RSB- .
20977501	0	IL-10	33,38	CD25	58,62	IL-10	CD25	3586	3559	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nmod|cells cells|compound|END_ENTITY	Neonatal BCG vaccination induces IL-10 production by CD4 + CD25 + T cells .
21533081	0	IL-10	28,33	CD25	45,49	IL-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	TLR2-dependent induction of IL-10 and Foxp3 + CD25 + CD4 + regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo .
22708352	0	IL-10	105,110	CD25	16,20	IL-10	CD25	281246(Tax:9913)	281861(Tax:9913)	Gene	Gene	production|nmod|START_ENTITY correlated|nmod|production correlated|nsubjpass|presence presence|nmod|END_ENTITY	The presence of CD25 on bovine WC1 + gammadelta T cells is positively correlated with their production of IL-10 and TGF-beta , but not IFN-gamma .
24452947	0	IL-10	146,151	CD25	38,42	IL-10	CD25	3586	3559	Gene	Gene	regulation|compound|START_ENTITY contributes|nmod|regulation contributes|nsubj|induction induction|nmod|cells cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
25316133	0	IL-10	130,135	CD25	41,45	IL-10	CD25	3586	3559	Gene	Gene	role|nmod|START_ENTITY changes|dep|role changes|nmod|levels levels|nmod|FoxP3 FoxP3|compound|END_ENTITY	Allergy-related changes in levels of CD8 + CD25 + FoxP3 -LRB- bright -RRB- Treg cells and FoxP3 mRNA expression in peripheral blood : the role of IL-10 or TGF-beta .
26829554	0	IL-10	13,18	CD25	37,41	IL-10	CD25	3586	3559	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|Correlates Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
26928119	0	IL-10	79,84	CD25	111,115	IL-10	CD25	3586	3559	Gene	Gene	production|compound|START_ENTITY production|acl:relcl|END_ENTITY	NAD -LRB- + -RRB- regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells independent .
8069928	0	IL-10	33,38	CD25	220,224	IL-10	CD25	3586	3559	Gene	Gene	interleukin-10|appos|START_ENTITY interplay|nmod|interleukin-10 interplay|dep|synergizes synergizes|nmod|expression expression|amod|IL-2 IL-2|xcomp|enhance enhance|nmod|mechanism mechanism|acl:relcl|different different|nmod|upregulation upregulation|nmod|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
9636688	0	IL-10	69,74	CD25	103,107	IL-10	CD25	3586	3559	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2 , IL-4 , and IL-10 secretion and expression of CD25 , CD40L , and CD69 .
10898505	0	IL-10	0,5	CD28	60,64	IL-10	CD28	3586	940	Gene	Gene	acts|nsubj|START_ENTITY acts|advcl|altering altering|dobj|co-stimulation co-stimulation|compound|END_ENTITY	IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway .
10973911	0	IL-10	44,49	CD28	91,95	IL-10	CD28	3586	940	Gene	Gene	basis|nmod|START_ENTITY basis|dep|phosphorylation phosphorylation|compound|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
10973911	0	IL-10	67,72	CD28	91,95	IL-10	CD28	3586	940	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
17531298	0	IL-10	0,5	CD28	15,19	IL-10	CD28	16153(Tax:10090)	12487(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|costimulations costimulations|compound|END_ENTITY	IL-10 inhibits CD28 and ICOS costimulations of T cells via src_homology_2_domain-containing_protein_tyrosine_phosphatase_1 .
22754764	0	IL-10	82,87	CD28	60,64	IL-10	CD28	3586	940	Gene	Gene	secretion|compound|START_ENTITY induced|dobj|secretion END_ENTITY|acl|induced	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
25382658	0	IL-10	78,83	CD28	119,123	IL-10	CD28	16153(Tax:10090)	12487(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY convert|iobj|cells convert|dobj|cells cells|nmod|END_ENTITY	Immature dendritic cells convert anergic nonregulatory T cells into Foxp3 -LRB- - -RRB- IL-10 -LRB- + -RRB- regulatory T cells by engaging CD28 and CTLA-4 .
9058822	0	IL-10	80,85	CD28	0,4	IL-10	CD28	16153(Tax:10090)	12487(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inducing|dobj|expression prevents|advcl|inducing prevents|nsubj|ligation ligation|compound|END_ENTITY	CD28 ligation prevents bacterial toxin-induced septic_shock in mice by inducing IL-10 expression .
10490963	0	IL-10	68,73	CD4	13,16	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	hyporesponsiveness|nmod|START_ENTITY hyporesponsiveness|nsubj|Induction Induction|nmod|alloantigen-specific alloantigen-specific|compound|END_ENTITY	Induction of CD4 + T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta .
11207250	0	IL-10	94,99	CD4	56,59	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY regulate|nmod|production regulate|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11207250	0	IL-10	94,99	CD4	6,9	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY regulate|nmod|production +|ccomp|regulate +|nsubj|END_ENTITY	CD25 + CD4 + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10 .
11489988	0	IL-10	61,66	CD4	30,33	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY increase|dobj|production lymphocytes|acl|increase lymphocytes|compound|END_ENTITY	Testosterone acts directly on CD4 + T lymphocytes to increase IL-10 production .
11809742	0	IL-10	114,119	CD4	8,11	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY CD25|dep|role CD25|compound|END_ENTITY	Natural CD4 CD25 -LRB- + -RRB- regulatory T cells control the burst of superantigen-induced cytokine production : the role of IL-10 .
12209095	0	IL-10	41,46	CD4	0,3	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY engineered|xcomp|produce cells|acl|engineered cells|nummod|END_ENTITY	CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway_hyperreactivity and inflammation .
12609834	0	IL-10	0,5	CD4	39,42	IL-10	CD4	3586	920	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|CD25 CD25|compound|END_ENTITY	IL-10 and TGF-beta induce alloreactive CD4 + CD25 - T cells to acquire regulatory cell function .
12789226	0	IL-10	13,18	CD4	19,22	IL-10	CD4	3586	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Induction of IL-10 + CD4 + CD25 + T cells by grass pollen immunotherapy .
12928371	0	IL-10	27,32	CD4	41,44	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY induces|nsubj|overexpression induces|dobj|populations populations|compound|END_ENTITY	Systemic overexpression of IL-10 induces CD4 + CD25 + cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion .
12938218	0	IL-10	76,81	CD4	26,29	IL-10	CD4	3586	920	Gene	Gene	secretion|dep|START_ENTITY wasting|dobj|secretion controls|xcomp|wasting controls|nsubj|subpopulation subpopulation|nmod|cells cells|nummod|END_ENTITY	A unique subpopulation of CD4 + regulatory T cells controls wasting disease , IL-10 secretion and T cell homeostasis .
1356125	0	IL-10	0,5	CD4	38,41	IL-10	CD4	3586	920	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|subsets subsets|nmod|clones clones|compound|END_ENTITY	IL-10 is produced by subsets of human CD4 + T cell clones and peripheral blood T cells .
1382908	0	IL-10	0,5	CD4	56,59	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|acl|arising arising|nmod|mouse mouse|compound|END_ENTITY	IL-10 production in a CD5 + B cell lymphoma arising in a CD4 monoclonal antibody-treated SJL mouse .
14519757	0	IL-10	52,57	CD4	92,95	IL-10	CD4	3586	920	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|+ +|compound|END_ENTITY	The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4 + CD25 + and CD8 + regulatory T cell subsets .
14607897	0	IL-10	62,67	CD4	0,3	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY +|dobj|role +|nsubj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + regulatory T cells cure murine colitis : the role of IL-10 , TGF-beta , and CTLA4 .
14734610	0	IL-10	0,5	CD4	90,93	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|cells cells|compound|END_ENTITY	IL-10 is involved in the suppression of experimental_autoimmune_encephalomyelitis by CD25 + CD4 + regulatory T cells .
15184347	0	IL-10	134,139	CD4	83,86	IL-10	CD4	3586	920	Gene	Gene	modulation|nmod|START_ENTITY type|amod|modulation cells|dep|type cells|acl|generated generated|nmod|presence presence|nmod|proliferation proliferation|compound|END_ENTITY	Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4 + T-cell proliferation : modulation by autocrine IL-10 , enhanced T-cell apoptosis and T regulatory type 1 cells .
15187167	0	IL-10	135,140	CD4	169,172	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY neutralization|nmod|production neutralization|nmod|cells cells|compound|END_ENTITY	Defective dendritic_cell_function_in_HIV-infected patients receiving effective highly active antiretroviral therapy : neutralization of IL-10 production and depletion of CD4 + CD25 + T cells restore high levels of HIV-specific CD4 + T cell responses induced by dendritic cells generated in the presence of IFN-alpha .
15187167	0	IL-10	135,140	CD4	223,226	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY neutralization|nmod|production neutralization|nmod|cells cells|dep|restore restore|dobj|levels levels|nmod|responses responses|compound|END_ENTITY	Defective dendritic_cell_function_in_HIV-infected patients receiving effective highly active antiretroviral therapy : neutralization of IL-10 production and depletion of CD4 + CD25 + T cells restore high levels of HIV-specific CD4 + T cell responses induced by dendritic cells generated in the presence of IFN-alpha .
15535835	0	IL-10	14,19	CD4	118,121	IL-10	CD4	3586	920	Gene	Gene	inhibition|compound|START_ENTITY Resistance|nmod|inhibition gamma|nsubj|Resistance gamma|dobj|production production|nmod|suppressor_of_cytokine_signaling_1 suppressor_of_cytokine_signaling_1|nmod|cells cells|compound|END_ENTITY	Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor_of_cytokine_signaling_1 in CD4 + T cells from patients with rheumatoid_arthritis .
15556685	0	IL-10	94,99	CD4	174,177	IL-10	CD4	3586	920	Gene	Gene	cells|appos|START_ENTITY suppress|nsubj|cells suppress|advcl|activating activating|dobj|cells cells|compound|END_ENTITY	Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 -LRB- IL-10 -RRB- suppress Th1-type responses while selectively activating IL-10-producing CD4 + T cells .
15688350	0	IL-10	86,91	CD4	25,28	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|co-localizes co-localizes|nmod|END_ENTITY	Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production .
15761493	0	IL-10	95,100	CD4	115,118	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY associated|nmod|production associated|nmod|cells cells|compound|END_ENTITY	Impaired humoral immunity in X-linked_lymphoproliferative_disease is associated with defective IL-10 production by CD4 + T cells .
15899924	0	IL-10	37,42	CD4	59,62	IL-10	CD4	3586	920	Gene	Gene	administration|compound|START_ENTITY administration|compound|END_ENTITY	Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration .
16791879	0	IL-10	110,115	CD4	117,120	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Distinct roles for IL-6 and IL-12p40 in mediating protection against Leishmania_donovani and the expansion of IL-10 + CD4 + T cells .
1680917	0	IL-10	14,19	CD4	23,26	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Production of IL-10 by CD4 + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth_infection .
16818744	0	IL-10	37,42	CD4	157,160	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY infiltrating|nsubj|cells immunity|acl|infiltrating Suppression|nmod|immunity Suppression|dep|influence influence|nmod|environment environment|nmod|induction induction|nmod|+ +|compound|END_ENTITY	Suppression of antitumor immunity by IL-10 and TGF-beta-producing T cells infiltrating the growing tumor : influence of tumor environment on the induction of CD4 + and CD8 + regulatory T cells .
16889540	0	IL-10	62,67	CD4	0,3	IL-10	CD4	3586	920	Gene	Gene	inducing|dobj|START_ENTITY Th1-autoimmunity|advcl|inducing limit|xcomp|Th1-autoimmunity limit|nsubj|cells cells|nummod|+25 +25|compound|END_ENTITY	CD4 +25 + regulatory T cells limit Th1-autoimmunity by inducing IL-10 producing T cells following human lung transplantation .
17015751	0	IL-10	13,18	CD4	62,65	IL-10	CD4	3586	920	Gene	Gene	suppressors|compound|START_ENTITY suppressors|nmod|patients patients|nmod|END_ENTITY	Induction of IL-10 suppressors in lung transplant patients by CD4 +25 + regulatory T cells through CTLA-4 signaling .
17196245	0	IL-10	119,124	CD4	141,144	IL-10	CD4	3586	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	CD25_deficiency causes an immune_dysregulation , polyendocrinopathy , enteropathy , X-linked-like_syndrome , and defective IL-10 expression from CD4 lymphocytes .
17237391	0	IL-10	97,102	CD4	25,28	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY depends|nmod|induction T|ccomp|depends T|csubj|occurring occurring|dobj|CD25 CD25|compound|END_ENTITY	Naturally occurring lung CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta .
17389235	0	IL-10	24,29	CD4	60,63	IL-10	CD4	3586	920	Gene	Gene	mRNA|compound|START_ENTITY accumulation|nmod|mRNA accumulation|dep|cells cells|amod|distinct distinct|nmod|+ +|compound|END_ENTITY	Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 + CD25 + -LRB- Foxp3 -RRB- regulatory T cells in human visceral_leishmaniasis .
17548634	0	IL-10	0,5	CD4	49,52	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|movement movement|nmod|intestinally intestinally|acl|derived derived|dobj|cells cells|nummod|END_ENTITY	IL-10 regulates movement of intestinally derived CD4 + T cells to the liver .
17675500	0	IL-10	0,5	CD4	63,66	IL-10	CD4	3586	920	Gene	Gene	excluded|nsubjpass|START_ENTITY excluded|nmod|memory memory|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-10 is excluded from the functional cytokine memory of human CD4 + memory T lymphocytes .
17675505	0	IL-10	147,152	CD4	105,108	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY reveal|nmod|source reveal|dobj|cells cells|nummod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17675505	0	IL-10	147,152	CD4	18,21	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY reveal|nmod|source reveal|nmod|cells cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17990114	0	IL-10	82,87	CD4	0,3	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY intestinal_inflammation|nmod|mice have|nmod|intestinal_inflammation have|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells have divergent effects on intestinal_inflammation in IL-10 gene-deficient mice .
18549444	0	IL-10	13,18	CD4	29,32	IL-10	CD4	3586	920	Gene	Gene	START_ENTITY|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	Induction of IL-10 producing CD4 + T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells .
18549444	0	IL-10	89,94	CD4	29,32	IL-10	CD4	3586	920	Gene	Gene	marrow|compound|START_ENTITY producing|nmod|marrow producing|dobj|cells cells|nummod|END_ENTITY	Induction of IL-10 producing CD4 + T cells with regulatory activities by stimulation with IL-10 gene-modified bone marrow derived dendritic cells .
18569073	0	IL-10	183,188	CD4	130,133	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	producing|dobj|START_ENTITY modulating|advcl|producing modulating|dobj|END_ENTITY	Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10 .
18634243	0	IL-10	18,23	CD4	88,91	IL-10	CD4	3586	920	Gene	Gene	Concentration|nmod|START_ENTITY cytokines|nsubj|Concentration cytokines|nmod|supernatants supernatants|nmod|+ +|compound|END_ENTITY	-LSB- Concentration of IL-10 , IL-13 and IFN-gamma cytokines in supernatants of microcultured CD4 + and NK cells in patients with non-allergic bronchial_asthma -RSB- .
19250511	0	IL-10	39,44	CD4	69,72	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY Helicobacter_infection|nmod|mice Reduction|nmod|Helicobacter_infection dependent|nsubj|Reduction dependent|nmod|cells cells|compound|END_ENTITY	Reduction of Helicobacter_infection in IL-10 - / - mice is dependent on CD4 + T cells but not on mast cells .
19535638	0	IL-10	33,38	CD4	49,52	IL-10	CD4	3586	920	Gene	Gene	generation|nmod|START_ENTITY cells|nsubj|generation cells|compound|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
19682278	0	IL-10	13,18	CD4	20,23	IL-10	CD4	3586	920	Gene	Gene	CD25|compound|START_ENTITY CD25|compound|END_ENTITY	Induction of IL-10 + CD4 + CD25 + regulatory T cells with decreased NF-kB expression during immunotherapy .
19748991	0	IL-10	16,21	CD4	37,40	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nmod|cells cells|nummod|END_ENTITY	IL-27 regulates IL-10 and IL-17 from CD4 + cells in nonhealing Leishmania_major_infection .
19849943	0	IL-10	42,47	CD4	12,15	IL-10	CD4	3586	920	Gene	Gene	levels|amod|START_ENTITY cells|appos|levels +|dobj|cells +|nsubj|Changes Changes|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Changes of CD4 + CD25 + regulatory T cells , IL-10 and TGF-beta1 levels in peripheral blood in children with asthma -RSB- .
20133700	0	IL-10	0,5	CD4	26,29	IL-10	CD4	3586	920	Gene	Gene	suppresses|dep|START_ENTITY suppresses|dobj|END_ENTITY	IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral_infection .
20177412	0	IL-10	0,5	CD4	28,31	IL-10	CD4	3586	920	Gene	Gene	required|dep|START_ENTITY required|nmod|END_ENTITY	IL-10 is required for human CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cell-mediated suppression of xenogeneic proliferation .
20544263	0	IL-10	0,5	CD4	108,111	IL-10	CD4	3586	920	Gene	Gene	START_ENTITY|appos|reduce reduce|nmod|insulin insulin|nmod|cells cells|nummod|END_ENTITY	IL-10 / TGF-beta-treated dendritic cells , pulsed with insulin , specifically reduce the response to insulin of CD4 + effector/memory T cells from type 1 diabetic individuals .
20723599	0	IL-10	0,5	CD4	38,41	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|cells cells|compound|END_ENTITY	IL-10 within the CNS is necessary for CD4 + T cells to mediate neuroprotection .
20809522	0	IL-10	0,5	CD4	52,55	IL-10	CD4	3586	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|T-cell T-cell|compound|END_ENTITY	IL-10 produced by activated human B cells regulates CD4 -LRB- + -RRB- T-cell activation in vitro .
20812238	0	IL-10	76,81	CD4	53,56	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY modulate|dobj|cells modulate|iobj|production production|nmod|T T|compound|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20812238	0	IL-10	76,81	CD4	6,9	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY modulate|dobj|cells T|ccomp|modulate T|nsubj|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20977501	0	IL-10	33,38	CD4	53,56	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nmod|cells cells|compound|END_ENTITY	Neonatal BCG vaccination induces IL-10 production by CD4 + CD25 + T cells .
21227406	0	IL-10	83,88	CD4	105,108	IL-10	CD4	3586	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human na ve CD4 + T cells .
21297642	0	IL-10	67,72	CD4	0,3	IL-10	CD4	3586	920	Gene	Gene	production|amod|START_ENTITY induce|dobj|production induce|nsubj|help help|compound|END_ENTITY	CD4 + T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs .
21440248	0	IL-10	15,20	CD4	40,43	IL-10	CD4	3586	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	IRF4 regulates IL-10 gene expression in CD4 -LRB- + -RRB- T cells through differential nuclear translocation .
21533081	0	IL-10	28,33	CD4	51,54	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	TLR2-dependent induction of IL-10 and Foxp3 + CD25 + CD4 + regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo .
21558138	0	IL-10	79,84	CD4	21,24	IL-10	CD4	3586	920	Gene	Gene	overproduction|nmod|START_ENTITY contribute|nmod|overproduction contribute|nsubj|cells cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
21844390	0	IL-10	54,59	CD4	9,12	IL-10	CD4	3586	920	Gene	Gene	produce|xcomp|START_ENTITY produce|nsubj|subsets subsets|compound|END_ENTITY	Multiple CD4 + T cell subsets produce immunomodulatory IL-10 during respiratory_syncytial_virus_infection .
21874651	0	IL-10	9,14	CD4	29,32	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Enhanced IL-10 production by CD4 + T cells primed in IL-15Ra-deficient mice .
22192790	0	IL-10	0,5	CD4	19,22	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	IL-10 signaling in CD4 + T cells is critical for the pathogenesis of collagen-induced arthritis .
22586040	0	IL-10	80,85	CD4	60,63	IL-10	CD4	3586	920	Gene	Gene	expression|compound|START_ENTITY alters|dobj|expression alters|nsubj|regulation regulation|nmod|family family|nmod|microRNAs microRNAs|nmod|cells cells|compound|END_ENTITY	Differential regulation of the Let-7 family of microRNAs in CD4 + T cells alters IL-10 expression .
22692497	0	IL-10	9,14	CD4	97,100	IL-10	CD4	3586	920	Gene	Gene	expression|compound|START_ENTITY confers|nsubj|expression confers|dobj|cell cell|acl:relcl|phenotype phenotype|nmod|T T|compound|END_ENTITY	Enforced IL-10 expression confers type 1 regulatory T cell -LRB- Tr1 -RRB- phenotype and function to human CD4 -LRB- + -RRB- T cells .
22754764	0	IL-10	82,87	CD4	112,115	IL-10	CD4	3586	920	Gene	Gene	secretion|compound|START_ENTITY induced|dobj|secretion induced|nmod|T T|compound|END_ENTITY	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
22842304	0	IL-10	94,99	CD4	114,117	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induce|dobj|production induce|nmod|cells cells|compound|END_ENTITY	Schistosoma_mansoni schistosomula tegument -LRB- Smteg -RRB- immunization in absence of adjuvant induce IL-10 production by CD4 + cells and failed to protect mice against challenge_infection .
22903229	0	IL-10	92,97	CD4	99,102	IL-10	CD4	3586	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	The role of 1a,25-dihydroxyvitamin _ D3 and cytokines in the promotion of distinct Foxp3 + and IL-10 + CD4 + T cells .
23292714	0	IL-10	118,123	CD4	146,149	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	IFN-y|compound|START_ENTITY numbers|nmod|IFN-y cells|nmod|numbers transfer|nmod|cells induced|nmod|transfer tolerance|acl|induced tolerance|dep|T T|compound|END_ENTITY	Immune tolerance induced by intravenous transfer of immature dendritic cells via up-regulating numbers of suppressive IL-10 -LRB- + -RRB- IFN-y -LRB- + -RRB- - producing CD4 -LRB- + -RRB- T cells .
23349024	0	IL-10	60,65	CD4	97,100	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4 + T cells .
23545299	0	IL-10	67,72	CD4	74,77	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
23997221	0	IL-10	135,140	CD4	109,112	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY shut|nmod|receptor shut|dobj|cells cells|compound|END_ENTITY	Mycobacteria-infected dendritic cells attract neutrophils that produce IL-10 and specifically shut down Th17 CD4 T cells through their IL-10 receptor .
24130479	0	IL-10	76,81	CD4	92,95	IL-10	CD4	3586	920	Gene	Gene	elicit|dobj|START_ENTITY elicit|xcomp|producing producing|dobj|cells cells|compound|END_ENTITY	Human_cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4 T cells .
24452947	0	IL-10	146,151	CD4	33,36	IL-10	CD4	3586	920	Gene	Gene	regulation|compound|START_ENTITY contributes|nmod|regulation contributes|nsubj|induction induction|nmod|cells cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
24568737	0	IL-10	99,104	CD4	76,79	IL-10	CD4	3586	920	Gene	Gene	cells|nmod|START_ENTITY T|nsubj|cells T|acl:relcl|T T|compound|END_ENTITY	Inhibition of TNF receptor signaling by anti-TNFa biologicals primes na ve CD4 -LRB- + -RRB- T cells towards IL-10 -LRB- + -RRB- T cells with a regulatory phenotype and function .
24598451	0	IL-10	98,103	CD4	68,71	IL-10	CD4	3586	920	Gene	Gene	secretion|compound|START_ENTITY suppress|nmod|secretion suppress|dobj|responses responses|compound|END_ENTITY	Ovarian_tumor ascites CD14 + cells suppress dendritic cell-activated CD4 + T-cell responses through IL-10 secretion and indoleamine 2,3-dioxygenase .
24613988	0	IL-10	121,126	CD4	141,144	IL-10	CD4	3586	920	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|cells cells|compound|END_ENTITY	Direct infection of dendritic cells during chronic viral_infection suppresses antiviral T cell proliferation and induces IL-10 expression in CD4 T cells .
24699268	0	IL-10	64,69	CD4	31,34	IL-10	CD4	3586	920	Gene	Gene	superfamily|amod|START_ENTITY members|amod|superfamily expressing|dobj|members Expansion|acl|expressing Expansion|nmod|+ +|compound|END_ENTITY	Expansion of parasite-specific CD4 + and CD8 + T cells expressing IL-10 superfamily cytokine members and their regulation in human lymphatic_filariasis .
24703254	0	IL-10	25,30	CD4	0,3	IL-10	CD4	403628(Tax:9615)	403931(Tax:9615)	Gene	Gene	produce|xcomp|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	CD4 + FOXP3 + cells produce IL-10 in the spleens of dogs with visceral_leishmaniasis .
25499021	0	IL-10	179,184	CD4	205,208	IL-10	CD4	3586	920	Gene	Gene	FoxP3|compound|START_ENTITY reduce|iobj|FoxP3 reduce|dobj|ratio ratio|nmod|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
25550089	0	IL-10	26,31	CD4	83,86	IL-10	CD4	3586	920	Gene	Gene	START_ENTITY|nmod|Tregs Tregs|acl|compromised compromised|nmod|T T|compound|END_ENTITY	Insufficient secretion of IL-10 by Tregs compromised its control on over-activated CD4 -LRB- + -RRB- T effector cells in newly diagnosed adult immune_thrombocytopenia patients .
25589067	0	IL-10	71,76	CD4	80,83	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	Induced|nmod|START_ENTITY Induced|nmod|END_ENTITY	A Novel Regulatory Macrophage Induced by a Helminth Molecule Instructs IL-10 in CD4 + T Cells and Protects against Mucosal_Inflammation .
25627813	0	IL-10	126,131	CD4	56,59	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY modification|nmod|promoter effector|nmod|modification effector|nsubj|expression expression|nmod|END_ENTITY	Glycogen synthase kinase-3 controls IL-10 expression in CD4 -LRB- + -RRB- effector T-cell subsets through epigenetic modification of the IL-10 promoter .
25627813	0	IL-10	36,41	CD4	56,59	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Glycogen synthase kinase-3 controls IL-10 expression in CD4 -LRB- + -RRB- effector T-cell subsets through epigenetic modification of the IL-10 promoter .
25974019	0	IL-10	56,61	CD4	88,91	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Suppressive|nsubj|Production Suppressive|nmod|Skin Skin|nmod|Cells Cells|compound|END_ENTITY	Helminth_Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4 + T Cells That Are Functionally Suppressive .
26140236	0	IL-10	0,5	CD4	77,80	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|END_ENTITY	IL-10 enhances CTL-mediated tumor rejection by inhibiting highly suppressive CD4 -LRB- + -RRB- T cells and promoting CTL persistence in a murine model of plasmacytoma .
26147684	0	IL-10	14,19	CD4	23,26	IL-10	CD4	3586	920	Gene	Gene	Production|nmod|START_ENTITY Production|dep|cells cells|amod|END_ENTITY	Production of IL-10 by CD4 -LRB- + -RRB- regulatory T cells during the resolution of infection promotes the maturation of memory CD8 -LRB- + -RRB- T cells .
26459508	0	IL-10	28,33	CD4	18,21	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Parasite-specific CD4 + IFN-y + IL-10 + T cells distribute within both lymphoid and non-lymphoid compartments and are controlled systemically by IL-27 and ICOS during blood-stage malaria_infection .
26639194	0	IL-10	0,5	CD4	25,28	IL-10	CD4	3586	920	Gene	Gene	IFNy|compound|START_ENTITY IFNy|nmod|T T|compound|END_ENTITY	IL-10 / IFNy co-expressing CD4 -LRB- + -RRB- T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses .
26639194	0	IL-10	51,56	CD4	25,28	IL-10	CD4	3586	920	Gene	Gene	DC|compound|START_ENTITY induced|nmod|DC cells|acl|induced T|dep|cells T|compound|END_ENTITY	IL-10 / IFNy co-expressing CD4 -LRB- + -RRB- T cells induced by IL-10 DC display a regulatory gene profile and downmodulate T cell responses .
26709703	0	IL-10	62,67	CD4	40,43	IL-10	CD4	3586	920	Gene	Gene	Secreting|amod|START_ENTITY Secreting|compound|END_ENTITY	Modulation of Cytokine Secretion Allows CD4 T Cells Secreting IL-10 and IL-17 to Simultaneously Participate in Maintaining Tolerance and Immunity .
26829554	0	IL-10	13,18	CD4	33,36	IL-10	CD4	3586	920	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|Correlates Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
26928119	0	IL-10	79,84	CD4	104,107	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY production|acl:relcl|CD25 CD25|compound|END_ENTITY	NAD -LRB- + -RRB- regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells independent .
27028319	0	IL-10	72,77	CD4	13,16	IL-10	CD4	3586	920	Gene	Gene	Recognition|compound|START_ENTITY Production|nmod|Recognition Pathway|nmod|Production +|dobj|Pathway +|nsubj|END_ENTITY	HIV-infected CD4 + T Cells Use T-bet-dependent Pathway for Production of IL-10 Upon Antigen Recognition .
27067196	0	IL-10	127,132	CD4	61,64	IL-10	CD4	3586	920	Gene	Gene	quality|nmod|START_ENTITY quality|compound|END_ENTITY	Effective antimalarial chemoprevention in childhood enhances CD4 + T cell quality and limits CD4 production of immunoregulatory IL-10 .
7684412	0	IL-10	18,23	CD4	44,47	IL-10	CD4	3586	920	Gene	Gene	START_ENTITY|nmod|subsets subsets|nmod|END_ENTITY	Direct effects of IL-10 on subsets of human CD4 + T cell clones and resting T cells .
8752931	0	IL-10	29,34	CD4	130,133	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY infected|nmod|absence infected|nmod|cells cells|amod|succumb succumb|nmod|response response|amod|dependent dependent|nmod|T T|compound|END_ENTITY	In the absence of endogenous IL-10 , mice acutely infected with Toxoplasma_gondii succumb to a lethal immune response dependent on CD4 + T cells and accompanied by overproduction of IL-12 , IFN-gamma and TNF-alpha .
8840221	0	IL-10	16,21	CD4	107,110	IL-10	CD4	3586	920	Gene	Gene	secretion|appos|START_ENTITY secretion|dep|T T|compound|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- secretion in systemic_lupus_erythematosus and rheumatoid_arthritis : IL-10-dependent CD4 + CD45RO + T cell-B cell antibody synthesis .
8918588	0	IL-10	8,13	CD4	27,30	IL-10	CD4	3586	920	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Reduced IL-10 secretion by CD4 + T lymphocytes expressing mutant cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- .
9352427	0	IL-10	74,79	CD4	62,65	IL-10	CD4	3586	920	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Increased in vitro induced CD4 + and CD8 + T cell IFN-gamma and CD4 + T cell IL-10 production in stable relapsing multiple_sclerosis .
9472657	0	IL-10	17,22	CD4	126,129	IL-10	CD4	3586	920	Gene	Gene	dysregulation|compound|START_ENTITY associated|nsubjpass|dysregulation associated|nmod|cells cells|nummod|END_ENTITY	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9472657	0	IL-10	17,22	CD4	40,43	IL-10	CD4	3586	920	Gene	Gene	dysregulation|compound|START_ENTITY dysregulation|nmod|cells cells|nummod|END_ENTITY	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9531324	0	IL-10	145,150	CD4	59,62	IL-10	CD4	3586	920	Gene	Gene	reversal|nmod|START_ENTITY pattern|dep|reversal exhibiting|dobj|pattern cells|dep|exhibiting cells|compound|END_ENTITY	Active Wegener 's _ granulomatosis is associated with HLA-DR + CD4 + T cells exhibiting an unbalanced Th1-type T cell cytokine pattern : reversal with IL-10 .
9759837	0	IL-10	23,28	CD4	53,56	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Urocanic acid enhances IL-10 production in activated CD4 + T cells .
9780221	0	IL-10	0,5	CD4	94,97	IL-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	impacts|nsubj|START_ENTITY impacts|dobj|diabetes diabetes|nmod|pathway pathway|nmod|requirement requirement|nmod|T T|compound|END_ENTITY	IL-10 impacts autoimmune diabetes via a CD8 + T cell pathway circumventing the requirement for CD4 + T and B lymphocytes .
10843746	0	IL-10	14,19	CD40	33,37	IL-10	CD40	3586	958	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|cells cells|compound|END_ENTITY	Production of IL-10 and IL-12 in CD40 and interleukin_4-activated mononuclear cells from patients with Graves ' _ disease .
10942246	0	IL-10	39,44	CD40	52,56	IL-10	CD40	3586	958	Gene	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	Mantle_cell_lymphoma proliferates upon IL-10 in the CD40 system .
11792123	0	IL-10	33,38	CD40	0,4	IL-10	CD40	3586	958	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|ligation ligation|compound|END_ENTITY	CD40 ligation induces macrophage IL-10 and TNF-alpha production : differential use of the PI3K and p42/44 MAPK-pathways .
12209589	0	IL-10	89,94	CD40	14,18	IL-10	CD40	16153(Tax:10090)	21939(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Inhibition Inhibition|nmod|expression expression|nummod|END_ENTITY	Inhibition of CD40 expression and CD40-mediated dendritic cell function by tumor-derived IL-10 .
17114447	0	IL-10	0,5	CD40	42,46	IL-10	CD40	3586	958	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor_of_cytokine_signaling-3 .
25341924	0	IL-10	25,30	CD40	80,84	IL-10	CD40	16153(Tax:10090)	21939(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY cells|nsubj|stimulation cells|amod|critical critical|nmod|enrichment enrichment|nmod|CD5 CD5|compound|END_ENTITY	Autocrine stimulation of IL-10 is critical to the enrichment of IL-10-producing CD40 -LRB- hi -RRB- CD5 -LRB- + -RRB- regulatory B cells in vitro and in vivo .
12393419	0	IL-10	68,73	CD5	6,9	IL-10	CD5	3586	921	Gene	Gene	production|compound|START_ENTITY stimulation|nmod|production promotes|nmod|stimulation promotes|nsubj|END_ENTITY	Human CD5 promotes B-cell survival through stimulation of autocrine IL-10 production .
1382908	0	IL-10	0,5	CD5	22,25	IL-10	CD5	16153(Tax:10090)	12507(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|lymphoma lymphoma|compound|END_ENTITY	IL-10 production in a CD5 + B cell lymphoma arising in a CD4 monoclonal antibody-treated SJL mouse .
19758163	0	IL-10	0,5	CD5	39,42	IL-10	CD5	3586	921	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	IL-10 production by B cells expressing CD5 with the alternative exon 1B .
21398617	0	IL-10	13,18	CD5	0,3	IL-10	CD5	3586	921	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	CD5 promotes IL-10 production in chronic_lymphocytic_leukemia B cells through STAT3 and NFAT2 activation .
21786452	0	IL-10	0,5	CD5	44,47	IL-10	CD5	3586	921	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|END_ENTITY	IL-10 is predominantly produced by CD19 -LRB- low -RRB- CD5 -LRB- + -RRB- regulatory B cell subpopulation : characterisation of CD19 -LRB- high -RRB- and CD19 -LRB- low -RRB- subpopulations of CD5 -LRB- + -RRB- B cells .
26964093	0	IL-10	0,5	CD5	61,64	IL-10	CD5	16153(Tax:10090)	12507(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Critical|nsubj|Production Critical|advcl|Sustaining Sustaining|dobj|Expansion Expansion|nmod|B B|compound|END_ENTITY	IL-10 Production Is Critical for Sustaining the Expansion of CD5 + B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice .
9184920	0	IL-10	40,45	CD5	49,52	IL-12	CD5	64546(Tax:10116)	12507(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	IL-12 directly stimulates expression of IL-10 by CD5 + B cells and IL-6 by both CD5 + and CD5 - B cells : possible involvement in age-associated cytokine dysregulation .
10940925	0	IL-10	88,93	CD8	28,31	IL-10	CD8	3586	925	Gene	Gene	phenotype|nmod|START_ENTITY T|nmod|phenotype T|nsubj|END_ENTITY	Glucocorticoids drive human CD8 -LRB- + -RRB- T cell differentiation towards a phenotype with high IL-10 and reduced IL-4 , IL-5 and IL-13 production .
11985521	0	IL-10	87,92	CD8	146,149	IL-10	CD8	3586	925	Gene	Gene	production|nmod|START_ENTITY cells|nmod|production effects|dep|cells effects|dep|role role|nmod|cells cells|nummod|+ +|compound|END_ENTITY	The effects of CD40 - _ and_interleukin -LRB- IL-4 -RRB- - activated CD23 + cells on the production of IL-10 by mononuclear cells in Graves ' _ disease : the role of CD8 + cells .
16951047	0	IL-10	10,15	CD8	82,85	IL-10	CD8	3586	925	Gene	Gene	overexpression|compound|START_ENTITY reduces|nsubj|overexpression reduces|nmod|cells cells|compound|END_ENTITY	Exogenous IL-10 overexpression reduces perforin production by activated allogenic CD8 + cells and prolongs cardiac allograft survival .
17544800	0	IL-10	0,5	CD8	16,19	IL-10	CD8	3586	925	Gene	Gene	START_ENTITY|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	IL-10 producing CD8 + T cells in human infection with Leishmania_guyanensis .
19535638	0	IL-10	33,38	CD8	90,93	IL-10	CD8	3586	925	Gene	Gene	generation|nmod|START_ENTITY cells|nsubj|generation cells|ccomp|suppress suppress|dobj|generation generation|nmod|responses responses|nummod|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
20089329	0	IL-10	24,29	CD8	0,3	IL-10	CD8	3586	925	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|nummod|END_ENTITY	CD8 + T cells expressing IL-10 are associated with a favourable prognosis in lung_cancer .
20127276	0	IL-10	82,87	CD8	113,116	IL-10	CD8	3586	925	Gene	Gene	synthesis|compound|START_ENTITY modulation|nmod|synthesis explain|dobj|modulation explain|nmod|T T|compound|END_ENTITY	sHLA-I Contamination , a novel mechanism to explain ex vivo/in vitro modulation of IL-10 synthesis and release in CD8 -LRB- + -RRB- T lymphocytes and in neutrophils following intravenous immunoglobulin infusion .
22581824	0	IL-10	0,5	CD8	52,55	IL-10	CD8	3586	925	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|amod|END_ENTITY	IL-10 directly activates and expands tumor-resident CD8 -LRB- + -RRB- T cells without de novo infiltration from secondary lymphoid organs .
23091017	0	IL-10	73,78	CD8	43,46	IL-10	CD8	3586	925	Gene	Gene	expression|compound|START_ENTITY abrogates|dobj|expression abrogates|nsubj|loss loss|nmod|responsiveness responsiveness|nmod|cells cells|compound|END_ENTITY	Persistent loss of IL-27 responsiveness in CD8 + memory T cells abrogates IL-10 expression in a recall response .
23264920	0	IL-10	37,42	CD8	77,80	IL-10	CD8	3586	925	Gene	Gene	activates|nsubj|START_ENTITY activates|ccomp|T T|nsubj|END_ENTITY	Autochthonous T cells to the rescue : IL-10 directly activates tumor-resident CD8 -LRB- + -RRB- T cells .
23666891	0	IL-10	10,15	CD8	108,111	IL-10	CD8	3586	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|immunity immunity|dep|role role|nmod|cytotoxicity cytotoxicity|amod|IL-10 IL-10|nmod|inducer inducer|nmod|T T|compound|END_ENTITY	Pegylated IL-10 induces cancer immunity : the surprising role of IL-10 as a potent inducer of IFN-y-mediated CD8 -LRB- + -RRB- T cell cytotoxicity .
23666891	0	IL-10	64,69	CD8	108,111	IL-10	CD8	3586	925	Gene	Gene	START_ENTITY|nmod|inducer inducer|nmod|T T|compound|END_ENTITY	Pegylated IL-10 induces cancer immunity : the surprising role of IL-10 as a potent inducer of IFN-y-mediated CD8 -LRB- + -RRB- T cell cytotoxicity .
25316133	0	IL-10	130,135	CD8	37,40	IL-10	CD8	3586	925	Gene	Gene	role|nmod|START_ENTITY changes|dep|role changes|nmod|levels levels|nmod|FoxP3 FoxP3|compound|END_ENTITY	Allergy-related changes in levels of CD8 + CD25 + FoxP3 -LRB- bright -RRB- Treg cells and FoxP3 mRNA expression in peripheral blood : the role of IL-10 or TGF-beta .
25446896	0	IL-10	11,16	CD8	24,27	IL-10	CD8	3586	925	Gene	Gene	blocks|nsubj|START_ENTITY blocks|dobj|responses responses|compound|END_ENTITY	Macrophage IL-10 blocks CD8 + T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells .
25751015	0	IL-10	10,15	CD8	46,49	IL-10	CD8	3586	925	Gene	Gene	blockade|compound|START_ENTITY enhance|nsubj|blockade enhance|ccomp|T T|nsubj|END_ENTITY	Transient IL-10 receptor blockade can enhance CD8 -LRB- + -RRB- T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen .
26147684	0	IL-10	14,19	CD8	118,121	IL-10	CD8	3586	925	Gene	Gene	Production|nmod|START_ENTITY promotes|nmod|Production promotes|dobj|maturation maturation|nmod|END_ENTITY	Production of IL-10 by CD4 -LRB- + -RRB- regulatory T cells during the resolution of infection promotes the maturation of memory CD8 -LRB- + -RRB- T cells .
26309093	0	IL-10	75,80	CD8	90,93	IL-10	CD8	3586	925	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	The Potentiation of IFN-y and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells .
7917114	0	IL-10	27,32	CD8	43,46	IL-10	CD8	3586	925	Gene	Gene	START_ENTITY|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
8104996	0	IL-10	6,11	CD8	37,40	IL-10	CD8	3586	925	Gene	Gene	chemoattractant|nsubj|START_ENTITY chemoattractant|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Human IL-10 is a chemoattractant for CD8 + T lymphocytes and an inhibitor of IL-8-induced CD4 + T lymphocyte migration .
9531274	0	IL-10	38,43	CD8	53,56	IL-10	CD8	3586	925	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|cells cells|compound|END_ENTITY	Inhibitory and stimulatory effects of IL-10 on human CD8 + T cells .
15661876	0	IL-10	23,28	CIITA	61,66	IL-10	CIITA	16153(Tax:10090)	12265(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Enhanced production of IL-10 by dendritic_cells_deficient in CIITA .
15634884	0	IL-10	0,5	CTLA-4	17,23	IL-10	CTLA-4	16153(Tax:10090)	12477(Tax:10090)	Gene	Gene	diminishes|nsubj|START_ENTITY diminishes|dobj|expression expression|compound|END_ENTITY	IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance .
17015751	0	IL-10	13,18	CTLA-4	97,103	IL-10	CTLA-4	3586	1493	Gene	Gene	suppressors|compound|START_ENTITY Induction|nmod|suppressors +|nsubj|Induction +|nmod|signaling signaling|compound|END_ENTITY	Induction of IL-10 suppressors in lung transplant patients by CD4 +25 + regulatory T cells through CTLA-4 signaling .
22547705	0	IL-10	0,5	CTLA-4	7,13	IL-10	CTLA-4	3586	1493	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-10 + CTLA-4 + Th2 inhibitory cells form in a Foxp3-independent , IL-2-dependent manner from Th2 effectors during chronic_inflammation .
23960017	0	IL-10	118,123	CTLA-4	12,18	IL-10	CTLA-4	3586	1493	Gene	Gene	suppress|nmod|START_ENTITY +|ccomp|suppress END_ENTITY|acl|+	Human CD14 + CTLA-4 + regulatory dendritic cells suppress T-cell response by cytotoxic_T-lymphocyte_antigen-4-dependent IL-10 and indoleamine-2 ,3 - dioxygenase production in hepatocellular_carcinoma .
17392576	0	IL-10	202,207	CXCL8	188,193	IL-10	CXCL8	3586	3576	Gene	Gene	IL-13|compound|START_ENTITY IL-8|appos|IL-13 IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
26732675	0	IL-10	0,5	CXCR3	20,25	IL-10	CXCR3	16153(Tax:10090)	12766(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites .
15221959	0	IL-10	38,43	Carcinoembryonic_antigen	0,24	IL-10	Carcinoembryonic antigen	3586	1084	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Carcinoembryonic_antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal_carcinoma cells .
22000570	0	IL-10	46,51	Corticotropin-releasing_hormone	0,31	IL-10	Corticotropin-releasing hormone	3586	1392	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Corticotropin-releasing_hormone downregulates IL-10 production by adaptive forkhead box protein 3-negative regulatory T cells in patients with atopic_dermatitis .
26170389	0	IL-10	20,25	DC-SCRIPT	0,9	IL-10	DC-SCRIPT	3586	167465	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-kBp65 Activation .
23533666	0	IL-10	19,24	Dectin-1	0,8	IL-10	Dectin-1	16153(Tax:10090)	56644(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers .
21468579	0	IL-10	0,5	E2_protein	37,47	IL-10	E2 protein	3586	7320	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	IL-10 expression is regulated by HPV E2_protein in cervical cancer cells .
21507199	0	IL-10	0,5	ERK	75,78	IL-10	ERK	3586	5594	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	IL-10 production in non-small_cell_lung_carcinoma patients is regulated by ERK , P38 and COX-2 .
24703254	0	IL-10	25,30	FOXP3	4,9	IL-10	FOXP3	403628(Tax:9615)	491876(Tax:9615)	Gene	Gene	produce|xcomp|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	CD4 + FOXP3 + cells produce IL-10 in the spleens of dogs with visceral_leishmaniasis .
24984993	0	IL-10	64,69	FOXP3	45,50	IL-10	FOXP3	3586	50943	Gene	Gene	cells|appos|START_ENTITY cells|nummod|END_ENTITY	Modulation of adipose tissue inflammation by FOXP3 + Treg cells , IL-10 , and TGF-b in metabolically healthy class III_obese individuals .
11441085	0	IL-10	73,78	Fc_epsilon_RI	14,27	IL-10	Fc epsilon RI	3586	2205	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|Engagement Engagement|nmod|END_ENTITY	Engagement of Fc_epsilon_RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells .
14978125	0	IL-10	0,5	Fc_epsilon_RI	15,28	IL-10	Fc epsilon RI	16153(Tax:10090)	14125(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-10 inhibits Fc_epsilon_RI expression in mouse mast cells .
26504851	0	IL-10	27,32	FoxP3	38,43	IL-10	FoxP3	3586	50943	Gene	Gene	Expansion|nmod|START_ENTITY END_ENTITY|nsubj|Expansion	The Expansion of CD25 -LRB- high -RRB- IL-10 -LRB- high -RRB- FoxP3 -LRB- high -RRB- B Regulatory Cells Is in Association with SLE_Disease Activity .
26829554	0	IL-10	13,18	FoxP3	42,47	IL-10	FoxP3	3586	50943	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|Correlates Correlates|compound|END_ENTITY	Induction of IL-10 and TGFb from CD4 + CD25 + FoxP3 + T Cells Correlates with Parasite Load in Indian Kala-azar_Patients_Infected with Leishmania_donovani .
17675505	0	IL-10	147,152	Foxp3	22,27	IL-10	Foxp3	16153(Tax:10090)	20371(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY reveal|nmod|source reveal|nmod|cells cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
21558138	0	IL-10	79,84	Foxp3	32,37	IL-10	Foxp3	3586	50943	Gene	Gene	overproduction|nmod|START_ENTITY contribute|nmod|overproduction contribute|nsubj|cells cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
24452947	0	IL-10	146,151	Foxp3	44,49	IL-10	Foxp3	3586	50943	Gene	Gene	regulation|compound|START_ENTITY contributes|nmod|regulation contributes|nsubj|induction induction|nmod|cells cells|compound|END_ENTITY	Increased apoptosis induction in CD4 + CD25 + Foxp3 + T cells contributes to enhanced disease activity in patients with rheumatoid_arthritis through IL-10 regulation .
26682056	0	IL-10	66,71	GATA3	20,25	IL-10	GATA3	3586	2625	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|nmod|END_ENTITY	Lower expression of GATA3 and T-bet correlates with downregulated IL-10 in severe falciparum_malaria .
14567558	0	IL-10	9,14	GM-CSF	24,30	IL-10	GM-CSF	3586	1437	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Elevated IL-10 inhibits GM-CSF synthesis in pulmonary_alveolar_proteinosis .
26826242	0	IL-10	128,133	GM-CSF	106,112	IL-10	GM-CSF	3586	1437	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Autoreactive T Cells from Patients with Myasthenia_Gravis Are Characterized by Elevated IL-17 , IFN-y , and GM-CSF and Diminished IL-10 Production .
8552986	0	IL-10	130,135	GM-CSF	165,171	IL-10	GM-CSF	3586	1437	Gene	Gene	G-CSF|appos|START_ENTITY erythrocytes|dep|G-CSF Adhesion|nmod|erythrocytes END_ENTITY|nsubj|Adhesion	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
9546312	0	IL-10	0,5	GM-CSF	84,90	IL-10	GM-CSF	3586	1437	Gene	Gene	secretion|amod|START_ENTITY secretion|dep|effects effects|nmod|secretion secretion|amod|END_ENTITY	IL-10 as an autocrine regulator of CSF secretion by monocytes : disparate effects on GM-CSF and G-CSF secretion .
22345665	0	IL-10	86,91	Galectin-1	0,10	IL-10	Galectin-1	3586	3956	Gene	Gene	expression|compound|START_ENTITY defined|nmod|expression cells|acl|defined signature|nmod|cells triggers|dobj|signature triggers|nsubj|END_ENTITY	Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression .
10330285	0	IL-10	0,5	HLA-G	26,31	IL-10	HLA-G	3586	3135	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes .
19142233	0	IL-10	0,5	HSP70	46,51	IL-10	HSP70	16153(Tax:10090)	15511(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis .
15240748	0	IL-10	39,44	Heme_oxygenase_1	0,16	IL-10	Heme oxygenase 1	3586	3162	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Heme_oxygenase_1 expression induced by IL-10 requires STAT-3 and phosphoinositol-3 kinase and is inhibited by lipopolysaccharide .
23808579	0	IL-10	69,74	Hsp70	14,19	IL-10	Hsp70	16153(Tax:10090)	15511(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Extracellular Hsp70 inhibits pro-inflammatory cytokine production by IL-10 driven down-regulation of C/EBPb and C/EBP .
10427988	0	IL-10	46,51	ICAM-1	108,114	IL-10	ICAM-1	3586	3383	Gene	Gene	results|nmod|START_ENTITY results|nmod|END_ENTITY	Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1 , ICAM-2 or ICAM-3 .
11122238	0	IL-10	99,104	ICAM-1	161,167	IL-10	ICAM-1	16153(Tax:10090)	15894(Tax:10090)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|expression expression|appos|END_ENTITY	Roles of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , transforming growth factor-beta -LRB- TGF-beta -RRB- , and IL-10 in the modulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by macrophages during mycobacterial_infection .
24103557	0	IL-10	110,115	ICAM-1	0,6	IL-10	ICAM-1	16153(Tax:10090)	15894(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induced|nmod|production granulomatosis|acl|induced exacerbates|dobj|granulomatosis exacerbates|nsubj|deficiency deficiency|compound|END_ENTITY	ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium_acnes through impaired IL-10 production by regulatory T cells .
9808340	0	IL-10	0,5	ICAM-1	15,21	IL-10	ICAM-1	3586	3383	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-10 inhibits ICAM-1 expression on human Langerhans cells but not on keratinocytes , dermal endothelial cells or fibroblasts .
12207353	0	IL-10	33,38	ICOS	0,4	IL-10	ICOS	3586	29851	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells .
21558138	0	IL-10	79,84	ICOS	26,30	IL-10	ICOS	3586	29851	Gene	Gene	overproduction|nmod|START_ENTITY contribute|nmod|overproduction contribute|nsubj|cells cells|compound|END_ENTITY	Elevated circulating CD4 + ICOS + Foxp3 + T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic_lupus_erythematosus .
25430775	0	IL-10	23,28	IFN	36,39	IL-10	IFN	3586	3439	Gene	Gene	role|nmod|START_ENTITY role|parataxis|END_ENTITY	The role of macrophage IL-10 / innate IFN interplay during virus-induced asthma .
25541082	0	IL-10	14,19	IFN-a	0,5	IL-10	IFN-a	3586	3439	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IFN-a induces IL-10 production and tilt the balance between Th1 and Th17 in Beh __ et_disease .
8569177	0	IL-10	124,129	IFN-alpha	131,140	IL-10	IFN-alpha	16153(Tax:10090)	111654(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
10447735	0	IL-10	74,79	IFN-gamma	32,41	IL-10	IFN-gamma	3586	3458	Gene	Gene	Th1-type|appos|START_ENTITY Th1-type|appos|END_ENTITY	Regulatory effects of Th1-type -LRB- IFN-gamma , IL-12 -RRB- and Th2-type cytokines -LRB- IL-10 , IL-13 -RRB- on parasite-specific cellular responsiveness in Onchocerca_volvulus-infected humans and exposed endemic controls .
10508240	0	IL-10	0,5	IFN-gamma	69,78	IL-10	IFN-gamma	3586	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|proliferation proliferation|nmod|END_ENTITY	IL-10 enhances NK cell proliferation , cytotoxicity and production of IFN-gamma when combined with IL-18 .
11323220	0	IL-10	0,5	IFN-gamma	19,28	IL-10	IFN-gamma	3586	3458	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|END_ENTITY	IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells : a possible mechanism in the inflammatory reaction of atopic_dermatitis .
11994711	0	IL-10	56,61	IFN-gamma	116,125	IL-10	IFN-gamma	3586	3458	Gene	Gene	START_ENTITY|nmod|elevation elevation|nmod|END_ENTITY	Suppression of human anti-inflammatory plasma cytokines IL-10 and IL-1RA with elevation of proinflammatory cytokine IFN-gamma during the isolation of the Antarctic winter .
12168827	1	IL-10	175,180	IFN-gamma	164,173	IL-10	IFN-gamma	3586	3458	Gene	Gene	balance|compound|START_ENTITY balance|amod|END_ENTITY	Correlation with the IFN-gamma : IL-10 balance .
12193230	0	IL-10	55,60	IFN-gamma	44,53	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
12517950	0	IL-10	50,55	IFN-gamma	0,9	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	IFN-gamma production is specifically regulated by IL-10 in mice made tolerant with anti-CD40 ligand antibody and intact active bone .
12734375	0	IL-10	19,24	IFN-gamma	68,77	IL-10	IFN-gamma	3586	3458	Gene	Gene	modes|nmod|START_ENTITY modes|acl|inhibit inhibit|dobj|production production|amod|END_ENTITY	Different modes of IL-10 and TGF-beta to inhibit cytokine-dependent IFN-gamma production : consequences for reversal of lipopolysaccharide desensitization .
14568953	0	IL-10	0,5	IFN-gamma	45,54	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|suppression suppression|nmod|response response|amod|END_ENTITY	IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host .
16301610	0	IL-10	52,57	IFN-gamma	70,79	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|suppress suppress|dobj|production production|amod|END_ENTITY	Cutting edge : CD8 + CD122 + regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8 + T cells .
16461742	0	IL-10	104,109	IFN-gamma	128,137	IL-10	IFN-gamma	3586	3458	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Regulation of PTX3 , a key component of humoral innate immunity in human dendritic cells : stimulation by IL-10 and inhibition by IFN-gamma .
16713974	0	IL-10	21,26	IFN-gamma	0,9	IL-10	IFN-gamma	3586	3458	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP -1 proteins .
16944581	0	IL-10	108,113	IFN-gamma	115,124	IL-10	IFN-gamma	3586	3458	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- Regulation of vitality and IL-10 receptor expression of human decidual stromal cells in early pregnancy by IL-10 , IFN-gamma -RSB- .
17182557	0	IL-10	43,48	IFN-gamma	0,9	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IFN-gamma negatively regulates CpG-induced IL-10 in bone marrow-derived dendritic cells .
17689526	0	IL-10	118,123	IFN-gamma	39,48	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY suppresses|parataxis|role suppresses|dobj|response response|amod|END_ENTITY	MDMA -LRB- `` Ecstasy '' -RRB- suppresses the innate IFN-gamma response in vivo : a critical role for the anti-inflammatory cytokine IL-10 .
18655171	0	IL-10	111,116	IFN-gamma	0,9	IL-10	IFN-gamma	3586	3458	Gene	Gene	synthase|dobj|START_ENTITY synthase|nsubj|synergizes synergizes|amod|END_ENTITY	IFN-gamma synergizes with LPS to induce nitric_oxide biosynthesis through glycogen synthase kinase-3-inhibited IL-10 .
18713986	0	IL-10	30,35	IFN-gamma	64,73	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY axis|dep|suppresses axis|amod|END_ENTITY	Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12 / IFN-gamma axis in lung-challenged aged mice .
18799001	0	IL-10	85,90	IFN-gamma	74,83	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	CpG Immunotherapy in Chenopodium album sensitized mice : The comparison of IFN-gamma , IL-10 and IgE responses in intranasal and subcutaneous administrations .
19266486	0	IL-10	0,5	IFN-gamma	43,52	IL-10	IFN-gamma	3586	3458	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	IL-10 interferes directly with TCR-induced IFN-gamma but not IL-17 production in memory T cells .
19535638	0	IL-10	33,38	IFN-gamma	0,9	IL-10	IFN-gamma	3586	3458	Gene	Gene	generation|nmod|START_ENTITY cells|nsubj|generation promotes|xcomp|cells promotes|nsubj|END_ENTITY	IFN-gamma promotes generation of IL-10 secreting CD4 + T cells that suppress generation of CD8 responses in an antigen-experienced host .
20042578	0	IL-10	0,5	IFN-gamma	64,73	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY limits|nsubj|induction limits|dobj|response response|amod|END_ENTITY	IL-10 induction by Bordetella_parapertussis limits a protective IFN-gamma response .
21591983	0	IL-10	40,45	IFN-gamma	53,62	IL-10	IFN-gamma	3586	3458	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
25272942	0	IL-10	38,43	IFN-gamma	15,24	IL-10	IFN-gamma	3586	3458	Gene	Gene	IL-17|dep|START_ENTITY END_ENTITY|dep|IL-17	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
7636207	0	IL-10	14,19	IFN-gamma	34,43	IL-10	IFN-gamma	3586	3458	Gene	Gene	expression|compound|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|transcription transcription|amod|END_ENTITY	Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes .
8015314	0	IL-10	130,135	IFN-gamma	90,99	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|dep|release release|amod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8108955	0	IL-10	78,83	IFN-gamma	24,33	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY production|dep|involvement production|nmod|END_ENTITY	Defective production of IFN-gamma in neonatally tolerant mice : involvement of IL-10 .
8564698	0	IL-10	11,16	IFN-gamma	45,54	IL-10	IFN-gamma	3586	3458	Gene	Gene	Effect|nmod|START_ENTITY antigen-induced|nsubj|Effect antigen-induced|dobj|production production|amod|END_ENTITY	-LSB- Effect of IL-10 on the mite antigen-induced IFN-gamma production by peripheral blood lymphocytes from individuals with bronchial_asthma -RSB- .
8608632	0	IL-10	44,49	IFN-gamma	32,41	IL-10	IFN-gamma	3586	3458	Gene	Gene	mRNA|amod|START_ENTITY Expression|nmod|mRNA Expression|appos|END_ENTITY	Expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-10 , IL-12 and transforming growth factor-beta -LRB- TGF-beta -RRB- mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid_arthritis -LRB- RA -RRB- .
8622992	0	IL-10	61,66	IFN-gamma	42,51	IL-10	IFN-gamma	3586	3458	Gene	Gene	START_ENTITY|nsubj|interleukin interleukin|dep|END_ENTITY	Comparative interleukin -LRB- IL-2 -RRB- / interferon IFN-gamma and IL-4 / IL-10 responses during acute infection of macaques inoculated with attenuated nef-truncated or pathogenic SICmac251 virus .
8757617	0	IL-10	38,43	IFN-gamma	49,58	IL-10	IFN-gamma	3586	3458	Gene	Gene	secreting|dobj|START_ENTITY secreting|nmod|END_ENTITY	IL-12 induces human T cells secreting IL-10 with IFN-gamma .
9328116	0	IL-10	53,58	IFN-gamma	18,27	IL-10	IFN-gamma	3586	3458	Gene	Gene	production|nmod|START_ENTITY regulates|dobj|production regulates|nsubj|Interferon-gamma Interferon-gamma|appos|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- regulates production of IL-10 and IL-12 in human_herpesvirus-6 _ -LRB- HHV-6 -RRB- - infected monocyte/macrophage lineage .
9670842	0	IL-10	82,87	IFN-gamma	25,34	IL-10	IFN-gamma	3586	3458	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|levels levels|compound|IL-4 IL-4|amod|END_ENTITY	Elevated serum levels of IFN-gamma , IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating_diseases during the acute stage .
9743342	0	IL-10	119,124	IFN-gamma	63,72	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10 : selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4 .
9767435	0	IL-10	11,16	IFN-gamma	27,36	IL-10	IFN-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Endogenous IL-10 regulates IFN-gamma and IL-5 cytokine production and the granulomatous response in Schistosomiasis_mansoni-infected mice .
25022962	0	IL-10	25,30	IFN-y	39,44	IL-10	IFN-y	3586	3458	Gene	Gene	IL-12|dep|START_ENTITY IL-12|dep|END_ENTITY	In situ cytokines -LRB- IL-4 , IL-10 , IL-12 , IFN-y -RRB- _ and_chemokines -LRB- MCP-1 , MIP-1a -RRB- gene expression in human Leishmania _ -LRB- Leishmania -RRB- _ Mexicana_infection .
26697005	0	IL-10	212,217	IFN-y	10,15	IL-10	IFN-y	3586	3458	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|dep|Regulation	Augmented IFN-y and TNF-a Induced by Probiotic Bacteria in NK Cells Mediate Differentiation of Stem-Like Tumors Leading to Inhibition of Tumor Growth and Reduction in Inflammatory Cytokine Release ; Regulation by IL-10 .
8874748	0	IL-10	105,110	IFN_gamma	112,121	IL-10	IFN gamma	3586	3458	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	Effects of Pityrosporum ovale on proliferation , immunoglobulin -LRB- IgA , G , M -RRB- synthesis and cytokine -LRB- IL-2 , IL-10 , IFN_gamma -RRB- production of peripheral blood mononuclear cells from patients with seborrhoeic_dermatitis .
10908889	0	IL-10	57,62	IFNgamma	24,32	IL-10	IFNgamma	3586	3458	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS. BACKGROUND : MS is a chronic inflammatory disease of the CNS postulated to be a Th1 type cell-mediated autoimmune_disease .
16716911	0	IL-10	115,120	IFNgamma	85,93	IL-10	IFNgamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	In vitro effects of genistein and resveratrol on the production of interferon-gamma -LRB- IFNgamma -RRB- and interleukin-10 -LRB- IL-10 -RRB- by stimulated murine splenocytes .
11640949	0	IL-10	85,90	IL-1	65,69	IL-10	IL-1	3586	3553	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Lack of association between human longevity and polymorphisms of IL-1 cluster , IL-6 , IL-10 and TNF-alpha genes in Finnish nonagenarians .
11723165	0	IL-10	0,5	IL-1	43,47	IL-10	IL-1	16153(Tax:10090)	111343(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	IL-10 and IL-4 regulate type-I and type-II IL-1 receptors expression on IL-1_beta-activated mouse primary astrocytes .
9551930	0	IL-10	23,28	IL-1	53,57	IL-10	IL-1	3586	3553	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha : role of the p38 and p42/44 mitogen-activated protein kinases .
8552986	0	IL-10	130,135	IL-1-beta	99,108	IL-10	IL-1-beta	3586	3553	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|compound|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
10209514	0	IL-10	0,5	IL-10	41,46	IL-10	IL-10	3586	3586	Gene	Gene	START_ENTITY|dep|levels levels|compound|END_ENTITY	IL-10 in HIV_infection : increasing serum IL-10 levels with disease progression -- down-regulatory effect of potent anti-retroviral therapy .
10209514	0	IL-10	41,46	IL-10	0,5	IL-10	IL-10	3586	3586	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|dep|levels	IL-10 in HIV_infection : increasing serum IL-10 levels with disease progression -- down-regulatory effect of potent anti-retroviral therapy .
10973911	0	IL-10	44,49	IL-10	67,72	IL-10	IL-10	3586	3586	Gene	Gene	basis|nmod|START_ENTITY basis|dep|phosphorylation phosphorylation|compound|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
10973911	0	IL-10	67,72	IL-10	44,49	IL-10	IL-10	3586	3586	Gene	Gene	phosphorylation|compound|START_ENTITY basis|dep|phosphorylation basis|nmod|END_ENTITY	A molecular basis for T cell suppression by IL-10 : CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase binding .
12496489	0	IL-10	0,5	IL-10	6,11	IL-10	IL-10	3586	3586	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	IL-10 / IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate_tumor lines .
12496489	0	IL-10	6,11	IL-10	0,5	IL-10	IL-10	3586	3586	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|appos|regulates	IL-10 / IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate_tumor lines .
12888334	0	IL-10	44,49	IL-10	9,14	IL-10	IL-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	effective|nmod|START_ENTITY effective|nsubj|END_ENTITY	Cellular IL-10 is more effective than viral IL-10 in decreasing venous_thrombosis .
12888334	0	IL-10	9,14	IL-10	44,49	IL-10	IL-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	effective|nsubj|START_ENTITY effective|nmod|END_ENTITY	Cellular IL-10 is more effective than viral IL-10 in decreasing venous_thrombosis .
10657629	0	IL-10	129,134	IL-10-related_T_cell-derived_inducible_factor	32,77	IL-10	IL-10-related T cell-derived inducible factor	3586	50616	Gene	Gene	related|nmod|START_ENTITY cytokine|xcomp|related cytokine|advcl|Cloning Cloning|nmod|END_ENTITY	Cloning and characterization of IL-10-related_T_cell-derived_inducible_factor -LRB- IL-TIF -RRB- , a novel cytokine structurally related to IL-10 and inducible by IL-9 .
11035029	0	IL-10	136,141	IL-10-related_T_cell-derived_inducible_factor	153,198	IL-10	IL-10-related T cell-derived inducible factor	3586	50616	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Identification of the functional interleukin-22 -LRB- IL-22 -RRB- receptor complex : the IL-10R2 chain -LRB- IL-10Rbeta -RRB- is a common chain of both the IL-10 and IL-22 -LRB- IL-10-related_T_cell-derived_inducible_factor , IL-TIF -RRB- receptor complexes .
18262271	0	IL-10	71,76	IL-12	65,70	IL-10	IL-12	25325(Tax:10116)	64546(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	CD40L stimulation of rat dendritic cells specifically favors the IL-12 / IL-10 ratio resulting in a strong T cell stimulatory capacity .
15821753	0	IL-10	111,116	IL-12p40	60,68	IL-10	IL-12p40	16153(Tax:10090)	16160(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY kinase|nsubj|role regulates|parataxis|kinase regulates|dobj|production production|compound|END_ENTITY	Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages : role of IL-10 and ERK1/2 kinase signaling .
9665281	0	IL-10	62,67	IL-12p40	39,47	IL-10	IL-12p40	16153(Tax:10090)	16160(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells .
23596310	0	IL-10	129,134	IL-17	0,5	IL-10	IL-17	3586	3605	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids .
25499021	0	IL-10	179,184	IL-17	162,167	IL-10	IL-17	3586	3605	Gene	Gene	FoxP3|compound|START_ENTITY FoxP3|amod|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
27007229	0	IL-10	64,69	IL-17F	92,98	IL-10	IL-17F	3586	112744	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY tumor_necrosis_factor-alpha|appos|END_ENTITY	Cytokine gene polymorphism -LSB- tumor_necrosis_factor-alpha -LRB- -308 -RRB- , IL-10 -LRB- -1082 -RRB- , IL-6 -LRB- -174 -RRB- , IL-17F , 1RaVNTR -RSB- in pediatric patients with primary immune_thrombocytopenia and response to different treatment modalities .
18841371	0	IL-10	51,56	IL-18	31,36	IL-10	IL-18	16153(Tax:10090)	16173(Tax:10090)	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|END_ENTITY	Therapeutic effect of low-dose IL-18 combined with IL-10 on collagen-induced_arthritis by down-regulation of inflammatory and Th1 responses and induction of Th2 responses .
8552986	0	IL-10	130,135	IL-1RA	110,116	IL-10	IL-1RA	3586	3557	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
9191887	0	IL-10	155,160	IL-1_beta	138,147	IL-10	IL-1 beta	3586	3553	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|compound|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
8777273	0	IL-10	0,5	IL-1ra	50,56	IL-10	IL-1ra	3586	3557	Gene	Gene	synergize|nsubj|START_ENTITY synergize|xcomp|induce induce|dobj|production production|compound|END_ENTITY	IL-10 and IL-4 synergize with TNF-alpha to induce IL-1ra production by human neutrophils .
10232394	0	IL-10	77,82	IL-2	43,47	IL-10	IL-2	25325(Tax:10116)	116562(Tax:10116)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|down-regulation down-regulation|nmod|production production|compound|END_ENTITY	Prostaglandin_E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis .
12030433	0	IL-10	43,48	IL-2	14,18	IL-10	IL-2	3586	3558	Gene	Gene	Th1|dep|START_ENTITY Th1|appos|END_ENTITY	Shift in Th1 -LRB- IL-2 and IFN-gamma -RRB- and Th2 -LRB- IL-10 and IL-4 -RRB- cytokine mRNA balance within two new histological main-types of rheumatoid-arthritis -LRB- RA -RRB- .
17144099	0	IL-10	31,36	IL-2	38,42	IL-10	IL-2	3586	3558	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
17392576	0	IL-10	202,207	IL-2	164,168	IL-10	IL-2	3586	3558	Gene	Gene	IL-13|compound|START_ENTITY IL-8|appos|IL-13 IL-8|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
18023521	0	IL-10	48,53	IL-2	0,4	IL-10	IL-2	3586	3558	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|activation activation|compound|END_ENTITY	IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells , HOZOT .
18407603	0	IL-10	24,29	IL-2	19,23	IL-10	IL-2	25325(Tax:10116)	116562(Tax:10116)	Gene	Gene	changes|dep|START_ENTITY changes|nmod|END_ENTITY	Dynamic changes of IL-2 / IL-10 , sFas and expression of Fas in intestinal mucosa in rats with acute_necrotizing_pancreatitis .
18582534	0	IL-10	25,30	IL-2	19,23	IL-10	IL-2	3586	3558	Gene	Gene	IL-4|compound|START_ENTITY END_ENTITY|dep|IL-4	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
18768844	0	IL-10	124,129	IL-2	67,71	IL-10	IL-2	3586	3558	Gene	Gene	locus|compound|START_ENTITY enhancer|nmod|locus enhanced|nmod|enhancer enhanced|nmod|END_ENTITY	The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus .
18768844	0	IL-10	18,23	IL-2	67,71	IL-10	IL-2	3586	3558	Gene	Gene	production|nmod|START_ENTITY enhanced|nsubjpass|production enhanced|nmod|END_ENTITY	The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus .
18972297	0	IL-10	0,5	IL-2	17,21	IL-10	IL-2	3586	3558	Gene	Gene	IL-12|compound|START_ENTITY IL-12|appos|END_ENTITY	IL-10 , TGF-beta , IL-2 , IL-12 , and IFN-gamma cytokine gene polymorphisms in asthma .
25272942	0	IL-10	38,43	IL-2	26,30	IL-10	IL-2	3586	3558	Gene	Gene	IL-17|dep|START_ENTITY IFN-gamma|dep|IL-17 IFN-gamma|dep|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
25953611	0	IL-10	156,161	IL-2	136,140	IL-10	IL-2	3586	3558	Gene	Gene	production|compound|START_ENTITY results|nmod|production results|compound|END_ENTITY	In autoimmune_hepatitis_type_1 or the autoimmune_hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression .
7520376	0	IL-10	106,111	IL-2	10,14	IL-10	IL-2	3586	3558	Gene	Gene	effect|compound|START_ENTITY effect|nmod|effect Effect|dep|effect Effect|nmod|END_ENTITY	Effect of IL-2 on immunoglobulin production by anti-CD40-activated human B cells : synergistic effect with IL-10 and antagonistic effect with IL-4 .
7827283	0	IL-10	48,53	IL-2	108,112	IL-10	IL-2	3586	3558	Gene	Gene	response|nmod|START_ENTITY Suppression|nmod|response Suppression|dep|role role|nmod|suppression suppression|nmod|synergy synergy|nmod|END_ENTITY	Suppression of the allogeneic response by human IL-10 : a critical role for suppression of a synergy between IL-2 and TNF-alpha .
8015314	0	IL-10	130,135	IL-2	85,89	IL-10	IL-2	16153(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8069928	0	IL-10	33,38	IL-2	116,120	IL-10	IL-2	3586	3558	Gene	Gene	interleukin-10|appos|START_ENTITY interplay|nmod|interleukin-10 interplay|dep|synergizes synergizes|nmod|expression expression|amod|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
8069928	0	IL-10	33,38	IL-2	59,63	IL-10	IL-2	3586	3558	Gene	Gene	interleukin-10|appos|START_ENTITY interleukin-10|appos|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
8228801	0	IL-10	16,21	IL-2	60,64	IL-10	IL-2	3586	3558	Gene	Gene	Interleukin_10|appos|START_ENTITY upregulates|nsubj|Interleukin_10 upregulates|dobj|receptors receptors|compound|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes .
8312229	0	IL-10	0,5	IL-2	64,68	IL-10	IL-2	3586	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|death death|nmod|cells cells|acl|starved starved|nmod|END_ENTITY	IL-10 inhibits apoptotic cell death in human T cells starved of IL-2 .
8569177	0	IL-10	124,129	IL-2	106,110	IL-10	IL-2	16153(Tax:10090)	16183(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|compound|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8617936	0	IL-10	57,62	IL-2	22,26	IL-10	IL-2	3586	3558	Gene	Gene	production|compound|START_ENTITY inducing|dobj|production synergizes|advcl|inducing synergizes|nmod|stimuli stimuli|compound|END_ENTITY	IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells .
8622992	0	IL-10	61,66	IL-2	25,29	IL-10	IL-2	3586	3558	Gene	Gene	START_ENTITY|nsubj|interleukin interleukin|appos|END_ENTITY	Comparative interleukin -LRB- IL-2 -RRB- / interferon IFN-gamma and IL-4 / IL-10 responses during acute infection of macaques inoculated with attenuated nef-truncated or pathogenic SICmac251 virus .
9510161	0	IL-10	14,19	IL-2	66,70	IL-10	IL-2	3586	3558	Gene	Gene	Production|nmod|START_ENTITY stimulated|nsubj|Production stimulated|nmod|IL-12 IL-12|compound|END_ENTITY	Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12 .
9916879	0	IL-10	0,5	IL-2	85,89	IL-10	IL-2	16153(Tax:10090)	16183(Tax:10090)	Gene	Gene	transfer|compound|START_ENTITY transfer|dep|inhibition inhibition|nmod|END_ENTITY	IL-10 gene transfer to intracranial 9L glioma : tumor inhibition and cooperation with IL-2 .
12407026	0	IL-10	22,27	IL-22	0,5	IL-10	IL-22	3586	50616	Gene	Gene	contrast|nmod|START_ENTITY END_ENTITY|nmod|contrast	IL-22 , in contrast to IL-10 , does not induce Ig production , due to absence of a functional IL-22 receptor on activated human B cells .
15682457	0	IL-10	19,24	IL-23	0,5	IL-10	IL-23	3586	51561	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human .
16751425	0	IL-10	134,139	IL-23	0,5	IL-10	IL-23	3586	51561	Gene	Gene	production|compound|START_ENTITY cells|nmod|production increased|nmod|cells increased|nsubjpass|END_ENTITY	IL-23 is increased in dendritic cells in multiple_sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production .
16751425	0	IL-10	134,139	IL-23	83,88	IL-10	IL-23	3586	51561	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	IL-23 is increased in dendritic cells in multiple_sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production .
18424480	0	IL-10	10,15	IL-23	143,148	IL-10	IL-23	3586	51561	Gene	Gene	mRNA|compound|START_ENTITY increases|nsubj|mRNA increases|advcl|reducing reducing|dobj|expression expression|compound|END_ENTITY	Increased IL-10 mRNA and IL-23 mRNA expression in multiple_sclerosis : interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression .
18424480	0	IL-10	106,111	IL-23	143,148	IL-10	IL-23	3586	51561	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|advcl|reducing reducing|dobj|expression expression|compound|END_ENTITY	Increased IL-10 mRNA and IL-23 mRNA expression in multiple_sclerosis : interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression .
20926331	0	IL-10	36,41	IL-24	6,11	IL-10	IL-24	3586	11009	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	mda-7 / IL-24 : a unique member of the IL-10 gene family promoting cancer-targeted_toxicity .
19748991	0	IL-10	16,21	IL-27	0,5	IL-10	IL-27	16153(Tax:10090)	246779(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	IL-27 regulates IL-10 and IL-17 from CD4 + cells in nonhealing Leishmania_major_infection .
22205023	0	IL-10	15,20	IL-27	0,5	IL-10	IL-27	16153(Tax:10090)	246779(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	IL-27 promotes IL-10 production by effector Th1 CD4 + T cells : a critical mechanism for protection from severe immunopathology during malaria_infection .
7819101	0	IL-10	26,31	IL-2_receptor	44,57	IL-10	IL-2 receptor	3586	3560	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Prognostic value of serum IL-10 and soluble IL-2_receptor levels in aggressive non-Hodgkin 's _ lymphoma .
10433804	0	IL-10	88,93	IL-4	56,60	IL-10	IL-4	3586	3565	Gene	Gene	upregulation|nmod|START_ENTITY downregulation|acl|upregulation downregulation|nmod|END_ENTITY	Hyaluronectin secretion by monocytes : downregulation by IL-4 and IL-13 , upregulation by IL-10 .
11529906	0	IL-10	92,97	IL-4	86,90	IL-10	IL-4	3586	3565	Gene	Gene	IFN-gamma|dep|START_ENTITY IFN-gamma|dep|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
11550960	0	IL-10	16,21	IL-4	28,32	IL-10	IL-4	3586	3565	Gene	Gene	Interleukin_10|appos|START_ENTITY Interleukin_10|appos|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- , not IL-4 or interferon-gamma production , correlates with progression of joint destruction in rheumatoid_arthritis .
11698430	0	IL-10	0,5	IL-4	71,75	IL-10	IL-4	3586	3565	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|suppress suppress|nsubj|END_ENTITY	IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-gamma suppress it .
11985521	0	IL-10	87,92	IL-4	38,42	IL-10	IL-4	3586	3565	Gene	Gene	production|nmod|START_ENTITY cells|nmod|production effects|dep|cells effects|dep|and_interleukin and_interleukin|appos|END_ENTITY	The effects of CD40 - _ and_interleukin -LRB- IL-4 -RRB- - activated CD23 + cells on the production of IL-10 by mononuclear cells in Graves ' _ disease : the role of CD8 + cells .
12371537	0	IL-10	134,139	IL-4	0,4	IL-10	IL-4	3586	3565	Gene	Gene	stimulation|nmod|START_ENTITY show|nmod|stimulation supplemented|ccomp|show supplemented|nsubj|END_ENTITY	IL-4 supplemented B-cell cultures of allergic children show reduced IgA and IgG production in response to additional stimulation with IL-10 .
14514890	0	IL-10	28,33	IL-4	96,100	IL-10	IL-4	3586	3565	Gene	Gene	expression|compound|START_ENTITY memory|nmod|expression Establishment|nmod|memory requires|nsubj|Establishment requires|dobj|costimulation costimulation|compound|END_ENTITY	Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation .
1588047	0	IL-10	0,5	IL-4	22,26	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|factor-beta factor-beta|compound|END_ENTITY	IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity .
16365450	0	IL-10	32,37	IL-4	25,29	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	responses|dep|START_ENTITY responses|nmod|END_ENTITY	Chemotactic responses of IL-4 - , IL-10 - , and IFN-gamma-producing CD4 + T cells depend on tissue origin and microbial stimulus .
16513385	0	IL-10	32,37	IL-4	62,66	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY chronic_colitis|nmod|mice Induction|nmod|chronic_colitis requires|nsubj|Induction requires|dobj|END_ENTITY	Induction of chronic_colitis in IL-10 deficient mice requires IL-4 .
16517715	0	IL-10	29,34	IL-4	58,62	IL-10	IL-4	3586	3565	Gene	Gene	locus|nsubj|START_ENTITY locus|nmod|END_ENTITY	GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4 + T cells .
17021766	0	IL-10	24,29	IL-4	18,22	IL-10	IL-4	3586	3565	Gene	Gene	TGF-beta1|compound|START_ENTITY mRNA|compound|TGF-beta1 mononuclear|nsubj|mRNA mononuclear|nmod|levels levels|nmod|END_ENTITY	In vivo levels of IL-4 , IL-10 , TGF-beta1 and IFN-gamma mRNA of the peripheral blood mononuclear cells in patients with alopecia areata in comparison to those in patients with atopic_dermatitis .
17392576	0	IL-10	202,207	IL-4	170,174	IL-10	IL-4	3586	3565	Gene	Gene	IL-13|compound|START_ENTITY IL-8|appos|IL-13 IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17675505	0	IL-10	147,152	IL-4	69,73	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY reveal|nmod|source reveal|nsubj|mice mice|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
18475727	0	IL-10	49,54	IL-4	43,47	IL-10	IL-4	3586	3565	Gene	Gene	IL-13|dep|START_ENTITY IL-13|compound|END_ENTITY	Regulation by anti-inflammatory cytokines -LRB- IL-4 , IL-10 , IL-13 , TGFbeta -RRB- of interleukin-8 production by LPS - and / or TNFalpha-activated human polymorphonuclear cells .
18775694	0	IL-10	49,54	IL-4	55,59	IL-10	IL-4	3586	3565	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|parataxis|stem stem|nsubj|END_ENTITY	Upregulation of chemokine_receptor expression by IL-10 / IL-4 in adult neural stem cells .
20812238	0	IL-10	76,81	IL-4	104,108	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
22484241	0	IL-10	77,82	IL-4	33,37	IL-10	IL-4	3586	3565	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|actions actions|nmod|END_ENTITY	The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10 , RP105 or the kinase activity of RIPK2 .
23545299	0	IL-10	67,72	IL-4	60,64	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY induce|dobj|T induce|iobj|interleukin-4 interleukin-4|appos|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
24578755	0	IL-10	45,50	IL-4	27,31	IL-10	IL-4	3586	3565	Gene	Gene	START_ENTITY|nsubj|Assessment Assessment|nmod|END_ENTITY	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
25022962	0	IL-10	25,30	IL-4	19,23	IL-10	IL-4	3586	3565	Gene	Gene	IL-12|dep|START_ENTITY IL-12|compound|END_ENTITY	In situ cytokines -LRB- IL-4 , IL-10 , IL-12 , IFN-y -RRB- _ and_chemokines -LRB- MCP-1 , MIP-1a -RRB- gene expression in human Leishmania _ -LRB- Leishmania -RRB- _ Mexicana_infection .
25267883	0	IL-10	0,5	IL-4	58,62	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|phenotype phenotype|nmod|macrophages macrophages|acl|induced induced|nmod|END_ENTITY	IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration .
25272942	0	IL-10	38,43	IL-4	32,36	IL-10	IL-4	3586	3565	Gene	Gene	IL-17|dep|START_ENTITY IL-17|compound|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
25942601	0	IL-10	81,86	IL-4	16,20	IL-10	IL-4	3586	3565	Gene	Gene	production|compound|START_ENTITY promoting|nmod|production T|parataxis|promoting T|nsubj|effect effect|nmod|END_ENTITY	A new effect of IL-4 on human y T cells : promoting regulatory V 1 T cells via IL-10 production and inhibiting function of V 2 T cells .
7520376	0	IL-10	106,111	IL-4	141,145	IL-10	IL-4	3586	3565	Gene	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Effect of IL-2 on immunoglobulin production by anti-CD40-activated human B cells : synergistic effect with IL-10 and antagonistic effect with IL-4 .
7665991	0	IL-10	0,5	IL-4	66,70	IL-10	IL-4	3586	3565	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|nmod|presence presence|nmod|END_ENTITY	IL-10 up-regulates human monocyte phagocytosis in the presence of IL-4 and IFN-gamma .
7749574	0	IL-10	0,5	IL-4	111,115	IL-10	IL-4	3586	3565	Gene	Gene	secretion|compound|START_ENTITY correlates|nsubj|secretion correlates|nmod|that that|nmod|END_ENTITY	IL-10 secretion of allergen-specific skin-derived T cells correlates positively with that of the Th2 cytokines IL-4 and IL-5 .
7954438	0	IL-10	158,163	IL-4	140,144	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|compound|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8015314	0	IL-10	130,135	IL-4	125,129	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|dep|release release|nmod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8569177	0	IL-10	124,129	IL-4	112,116	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8660851	0	IL-10	24,29	IL-4	0,4	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	release|compound|START_ENTITY modulate|dobj|release modulate|nsubj|END_ENTITY	IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes .
8836916	0	IL-10	100,105	IL-4	26,30	IL-10	IL-4	3586	3565	Gene	Gene	IL-1RA|dep|START_ENTITY release|nmod|IL-1RA release|compound|END_ENTITY	Dexamethasone antagonizes IL-4 and IL-10-induced release of IL-1RA by monocytes but augments IL-4 - , IL-10 - , and TGF-beta-induced suppression of TNF-alpha release .
9034992	0	IL-10	47,52	IL-4	40,44	IL-10	IL-4	3586	3565	Gene	Gene	interleukin_4|amod|START_ENTITY interleukin_4|appos|END_ENTITY	Elevated serum levels of interleukin_4 -LRB- IL-4 -RRB- , IL-10 , and IL-13 in patients with systemic_sclerosis .
9042433	0	IL-10	21,26	IL-4	0,4	IL-10	IL-4	3586	3565	Gene	Gene	MoAbs|amod|START_ENTITY synergizes|nmod|MoAbs synergizes|nsubj|END_ENTITY	IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency .
9042435	0	IL-10	36,41	IL-4	18,22	IL-10	IL-4	3586	3565	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Contrary roles of IL-4 and IL-12 on IL-10 production and proliferation of human tumour reactive T cells .
9286389	1	IL-10	71,76	IL-4	144,148	IL-10	IL-4	3586	3565	Gene	Gene	pretreated|nsubj|START_ENTITY pretreated|ccomp|can can|advcl|secrete secrete|dobj|END_ENTITY	IL-10 pretreated dendritic cells can prime naive CD4 + T cells to secrete IL-4 .
9310827	0	IL-10	40,45	IL-4	0,4	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY abrogates|dobj|effect abrogates|nsubj|END_ENTITY	IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental_allergic_encephalomyelitis in SJL mice .
9558023	0	IL-10	0,5	IL-4	22,26	IL-10	IL-4	3586	3565	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IL-10 synergizes with IL-4 and IL-13 in inhibiting lysosomal enzyme secretion by human monocytes and lamina propria mononuclear cells from patients with inflammatory_bowel_disease .
9558124	0	IL-10	52,57	IL-4	38,42	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	not|dep|START_ENTITY Requirement|dep|not Requirement|nmod|production production|nmod|END_ENTITY	Requirement for in vivo production of IL-4 , but not IL-10 , in the induction of proliferative suppression by filarial parasites .
9570548	0	IL-10	52,57	IL-4	38,42	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	not|dep|START_ENTITY Requirement|dep|not Requirement|nmod|production production|nmod|END_ENTITY	Requirement for in vivo production of IL-4 , but not IL-10 , in the induction of proliferative suppression by filarial parasites .
9619374	1	IL-10	168,173	IL-4	163,167	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY benefit|dep|therapy benefit|nmod|END_ENTITY	More therapeutic benefit with IL-4 / IL-10 combination therapy than with IL-10 treatment alone .
9619374	1	IL-10	204,209	IL-4	163,167	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	treatment|compound|START_ENTITY therapy|nmod|treatment benefit|dep|therapy benefit|nmod|END_ENTITY	More therapeutic benefit with IL-4 / IL-10 combination therapy than with IL-10 treatment alone .
9626996	0	IL-10	152,157	IL-4	117,121	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	IL-4|nmod|START_ENTITY IL-4|compound|IL-10 IL-10|compound|END_ENTITY	Gender variations in early Theiler 's _ virus induced demyelinating_disease : differential susceptibility and effects of IL-4 , IL-10 and combined IL-4 with IL-10 .
9670842	0	IL-10	82,87	IL-4	36,40	IL-10	IL-4	3586	3565	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|levels levels|compound|END_ENTITY	Elevated serum levels of IFN-gamma , IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating_diseases during the acute stage .
9723687	0	IL-10	135,140	IL-4	177,181	IL-10	IL-4	3586	3565	Gene	Gene	cells|compound|START_ENTITY treated|nmod|cells treated|xcomp|secrete secrete|dobj|END_ENTITY	Induction of Th2 cell differentiation in the primary immune response : dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4 + T cells to secrete IL-4 .
9743342	0	IL-10	119,124	IL-4	80,84	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY IFN-gamma|dep|induction IFN-gamma|nmod|END_ENTITY	Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10 : selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4 .
9886391	0	IL-10	14,19	IL-4	0,4	IL-10	IL-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement .
10671193	0	IL-10	0,5	IL-5	26,30	IL-10	IL-5	16153(Tax:10090)	16191(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY prevents|nsubj|deficiency prevents|dobj|overproduction overproduction|compound|END_ENTITY	IL-10 deficiency prevents IL-5 overproduction and eosinophilic_inflammation in a murine model of asthma-like reaction .
14561490	0	IL-10	0,5	IL-5	67,71	IL-10	IL-5	16153(Tax:10090)	16191(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|parataxis|overlap overlap|nmod|END_ENTITY	IL-10 induces gene expression in macrophages : partial overlap with IL-5 but not with IL-4 induced genes .
17392576	0	IL-10	202,207	IL-5	176,180	IL-10	IL-5	3586	3567	Gene	Gene	IL-13|compound|START_ENTITY IL-8|appos|IL-13 IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
26282695	0	IL-10	110,115	IL-5	97,101	IL-10	IL-5	3586	3567	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Cytokine profile of food-allergic post-liver transplant children is identified by high levels of IL-5 and low IL-10 secretion from patients ' peripheral blood mononuclear cells .
26282695	0	IL-10	110,115	IL-5	97,101	IL-10	IL-5	3586	3567	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Cytokine profile of food-allergic post-liver transplant children is identified by high levels of IL-5 and low IL-10 secretion from patients ' peripheral blood mononuclear cells .
7512591	0	IL-10	75,80	IL-5	18,22	IL-10	IL-5	3586	3567	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|production production|compound|END_ENTITY	B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10 .
8683140	0	IL-10	14,19	IL-5	39,43	IL-10	IL-5	16153(Tax:10090)	16191(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	Modulation by IL-10 of antigen-induced IL-5 generation , and CD4 + T lymphocyte and eosinophil infiltration into the mouse peritoneal cavity .
10219249	0	IL-10	10,15	IL-6	39,43	IL-10	IL-6	3586	3569	Gene	Gene	down-regulate|nsubj|START_ENTITY down-regulate|dobj|production production|compound|END_ENTITY	Exogenous IL-10 and IL-4 down-regulate IL-6 production by SLE-derived PBMC .
10580806	0	IL-10	0,5	IL-6	110,114	IL-10	IL-6	3586	3569	Gene	Gene	levels|compound|START_ENTITY levels|dep|relationship relationship|nmod|function function|amod|END_ENTITY	IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain_injury : relationship to IL-6 , TNF-alpha , TGF-beta1 and blood-brain barrier function .
10880248	0	IL-10	101,106	IL-6	95,99	IL-10	IL-6	16153(Tax:10090)	16193(Tax:10090)	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Innate resistance to experimental African trypanosomiasis : differences in cytokine -LRB- TNF-alpha , IL-6 , IL-10 and IL-12 -RRB- production by bone marrow-derived macrophages from resistant and susceptible mice .
11022130	0	IL-10	49,54	IL-6	76,80	IL-10	IL-6	3586	3569	Gene	Gene	START_ENTITY|nmod|cytokines cytokines|amod|interleukin-6 interleukin-6|dep|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11022130	0	IL-10	49,54	IL-6	98,102	IL-10	IL-6	3586	3569	Gene	Gene	START_ENTITY|nmod|cytokines cytokines|dep|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11179490	0	IL-10	33,38	IL-6	0,4	IL-10	IL-6	3586	3569	Gene	Gene	production|compound|START_ENTITY regulation|nmod|production regulation|compound|END_ENTITY	IL-6 and IFN-gamma regulation of IL-10 production by human colon_carcinoma cells .
11507020	0	IL-10	39,44	IL-6	76,80	IL-10	IL-6	16153(Tax:10090)	16193(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY increased|nsubjpass|levels increased|nmod|mice mice|compound|END_ENTITY	Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice .
11529906	0	IL-10	92,97	IL-6	34,38	IL-10	IL-6	3586	3569	Gene	Gene	IFN-gamma|dep|START_ENTITY cytokines|appos|IFN-gamma cytokines|amod|cytokines cytokines|dep|IL-17 IL-17|appos|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
12538454	0	IL-10	107,112	IL-6	167,171	IL-10	IL-6	3586	3569	Gene	Gene	responses|amod|START_ENTITY responses|compound|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|advmod|END_ENTITY	Repeated administrations of interleukin -LRB- IL -RRB- -12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma , _ tumor_necrosis_factor-alpha , IL-6 , and IL-8 responses .
12784729	0	IL-10	112,117	IL-6	118,122	IL-10	IL-6	3586	3569	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|nsubj|ratio ratio|compound|END_ENTITY	-LSB- A case of intraocular malignant_lymphoma diagnosed by immunoglobulin gene rearrangement and translocation , and IL-10 / IL-6 ratio in the vitreous fluid -RSB- .
14737948	0	IL-10	80,85	IL-6	32,36	IL-10	IL-6	3586	3569	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of interleukin-6 -LRB- IL-6 -RRB- , interleukin-8 -LRB- IL-8 -RRB- and interleukin-10 -LRB- IL-10 -RRB- in blood serum of breast_cancer patients .
15034082	0	IL-10	39,44	IL-6	100,104	IL-10	IL-6	3586	3569	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|acl|induced induced|nmod|END_ENTITY	Recruitment of STAT3 for production of IL-10 by colon_carcinoma cells induced by macrophage-derived IL-6 .
15848524	0	IL-10	63,68	IL-6	57,61	IL-10	IL-6	3586	3569	Gene	Gene	MCP-1|dep|START_ENTITY MCP-1|compound|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
15972146	0	IL-10	22,27	IL-6	70,74	IL-10	IL-6	3586	3569	Gene	Gene	effect|nmod|START_ENTITY induced|nsubj|effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Regulatory effect of IL-10 on expression of tissue factor induced by IL-6 in peripheral blood mononuclear cells -RSB- .
16696312	0	IL-10	48,53	IL-6	80,84	IL-10	IL-6	3586	3569	Gene	Gene	cytokine|amod|START_ENTITY levels|nmod|cytokine cytokine|nsubj|levels cytokine|dobj|END_ENTITY	Plasma levels of the anti-inflammatory cytokine IL-10 and inflammatory cytokine IL-6 in patients with unstable_angina .
17144099	0	IL-10	31,36	IL-6	44,48	IL-10	IL-6	3586	3569	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
17392576	0	IL-10	202,207	IL-6	182,186	IL-10	IL-6	3586	3569	Gene	Gene	IL-13|compound|START_ENTITY IL-8|appos|IL-13 IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17483704	0	IL-10	27,32	IL-6	21,25	IL-10	IL-6	3586	3569	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
18218915	0	IL-10	11,16	IL-6	28,32	IL-10	IL-6	16153(Tax:10090)	16193(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of IL-10 and age on IL-6 , IL-1beta , and TNF-alpha responses in mouse skeletal and cardiac muscle to an acute inflammatory insult .
18582534	0	IL-10	25,30	IL-6	32,36	IL-10	IL-6	3586	3569	Gene	Gene	IL-4|compound|START_ENTITY IL-4|dep|END_ENTITY	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
19300393	0	IL-10	47,52	IL-6	23,27	IL-10	IL-6	3586	3569	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Epicatechin suppresses IL-6 , IL-8 and enhances IL-10 production with NF-kappaB nuclear translocation in whole blood stimulated system .
19552919	0	IL-10	10,15	IL-6	74,78	IL-10	IL-6	3586	3569	Gene	Gene	concentrations|compound|START_ENTITY concentrations|nmod|association association|nmod|END_ENTITY	Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major_depression .
19936625	0	IL-10	31,36	IL-6	17,21	IL-10	IL-6	3586	3569	Gene	Gene	C/A|compound|START_ENTITY C|appos|C/A Polymorphisms|dep|C Polymorphisms|nmod|END_ENTITY	Polymorphisms of IL-6 174_G / C , IL-10 -592 C/A and risk of HIV/AIDS among North Indian population .
20055787	0	IL-10	37,42	IL-6	14,18	IL-10	IL-6	3586	3569	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|compound|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
21591983	0	IL-10	40,45	IL-6	47,51	IL-10	IL-6	3586	3569	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
22445721	0	IL-10	96,101	IL-6	91,95	IL-10	IL-6	3586	3569	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6 / IL-10 expression .
24578755	0	IL-10	45,50	IL-6	33,37	IL-10	IL-6	3586	3569	Gene	Gene	START_ENTITY|nsubj|Assessment Assessment|amod|IL-8 IL-8|amod|END_ENTITY	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
24741587	0	IL-10	117,122	IL-6	112,116	IL-10	IL-6	3586	3569	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|dep|axis	The robust and modulated biomarker network elicited by the Plasmodium_vivax infection is mainly mediated by the IL-6 / IL-10 axis and is associated with the parasite load .
24819026	0	IL-10	66,71	IL-6	60,64	IL-10	IL-6	3586	3569	Gene	Gene	IFN-y|dep|START_ENTITY IFN-y|compound|END_ENTITY	Prognostic importance of single-nucleotide polymorphisms in IL-6 , IL-10 , TGF-b1 , IFN-y , and TNF-a genes in chronic_phase_chronic_myeloid_leukemia .
7954438	0	IL-10	158,163	IL-6	146,150	IL-10	IL-6	16153(Tax:10090)	16193(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8552986	0	IL-10	130,135	IL-6	118,122	IL-10	IL-6	3586	3569	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8708914	0	IL-10	6,11	IL-6	63,67	IL-10	IL-6	16153(Tax:10090)	16193(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY inhibits|nsubj|therapy inhibits|dobj|TNF-alpha TNF-alpha|amod|END_ENTITY	Viral IL-10 gene therapy inhibits TNF-alpha and IL-1_beta , not IL-6 , in the newborn endotoxemic mouse .
8709636	0	IL-10	11,16	IL-6	115,119	IL-10	IL-6	3586	3569	Gene	Gene	START_ENTITY|nmod|factors factors|acl:relcl|involved involved|nmod|regulation regulation|compound|END_ENTITY	Effects of IL-10 and IL-4 on LPS-induced transcription factors -LRB- AP-1 , NF-IL6 and NF-kappa_B -RRB- which are involved in IL-6 regulation .
9067532	0	IL-10	107,112	IL-6	32,36	IL-10	IL-6	3586	3569	Gene	Gene	sinusoidal|nmod|START_ENTITY sinusoidal|nsubj|Regulation Regulation|nmod|production production|compound|END_ENTITY	Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10 .
9191887	0	IL-10	155,160	IL-6	149,153	IL-10	IL-6	3586	3569	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9472657	0	IL-10	17,22	IL-6	12,16	IL-10	IL-6	3586	3569	Gene	Gene	dysregulation|compound|START_ENTITY associated|nsubjpass|dysregulation END_ENTITY|parataxis|associated	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
7954438	0	IL-10	158,163	IL-7	152,156	IL-10	IL-7	16153(Tax:10090)	16196(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8569177	0	IL-10	124,129	IL-7	118,122	IL-10	IL-7	16153(Tax:10090)	16196(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
10069878	0	IL-10	18,23	IL-8	12,16	IL-10	IL-8	3586	3576	Gene	Gene	IL-13|appos|START_ENTITY IL-13|compound|END_ENTITY	Increase in IL-8 , IL-10 , IL-13 , and RANTES mRNA levels -LRB- in situ hybridization -RRB- in the nasal mucosa after nasal allergen provocation .
15804113	0	IL-10	36,41	IL-8	30,34	IL-10	IL-8	3586	3576	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	-LSB- Analysis of cytokines -LRB- IL-2 , IL-8 , IL-10 -RRB- in the expressed prostatic secretions of chronic_prostatitis -RSB- .
17392576	0	IL-10	202,207	IL-8	195,199	IL-10	IL-8	3586	3576	Gene	Gene	IL-13|compound|START_ENTITY END_ENTITY|appos|IL-13	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
20055787	0	IL-10	37,42	IL-8	20,24	IL-10	IL-8	3586	3576	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
23316107	0	IL-10	6,11	IL-8	0,4	IL-10	IL-8	3586	3576	Gene	Gene	TGF-b|appos|START_ENTITY TGF-b|compound|END_ENTITY	IL-8 , IL-10 , TGF-b , and GCSF levels were increased in severe persistent allergic_asthma patients with the anti-IgE treatment .
24578755	0	IL-10	45,50	IL-8	39,43	IL-10	IL-8	3586	3576	Gene	Gene	START_ENTITY|nsubj|Assessment Assessment|amod|END_ENTITY	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
26441050	0	IL-10	33,38	IL-8	27,31	IL-10	IL-8	3586	3576	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Cytokine modulation -LRB- IL-6 , IL-8 , IL-10 -RRB- by human breast milk lipids on intestinal epithelial cells -LRB- Caco-2 -RRB- .
8552986	0	IL-10	130,135	IL-8	124,128	IL-10	IL-8	3586	3576	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
9665590	0	IL-10	0,5	IL-8	38,42	IL-10	IL-8	3586	3576	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation .
10657629	0	IL-10	129,134	IL-9	152,156	IL-10	IL-9	3586	3578	Gene	Gene	related|nmod|START_ENTITY cytokine|xcomp|related cytokine|nmod|END_ENTITY	Cloning and characterization of IL-10-related_T_cell-derived_inducible_factor -LRB- IL-TIF -RRB- , a novel cytokine structurally related to IL-10 and inducible by IL-9 .
10820228	0	IL-10	93,98	IL-9	61,65	IL-10	IL-9	16153(Tax:10090)	16198(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY producers|dep|function producers|nmod|END_ENTITY	Murine bone marrow-derived mast cells as potent producers of IL-9 : costimulatory function of IL-10 and kit_ligand in the presence of IL-1 .
18997793	0	IL-10	91,96	IL-9	85,89	IL-10	IL-9	16153(Tax:10090)	16198(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IL-4 inhibits TGF-beta-induced Foxp3 + T cells and , together with TGF-beta , generates IL-9 + IL-10 + Foxp3 -LRB- - -RRB- effector T cells .
25627396	0	IL-10	43,48	IL10A	0,5	IL-10	IL10A	3586	3586	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon .
25627396	0	IL-10	43,48	IL10A	0,5	IL-10	IL10A	3586	3586	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon .
22786766	0	IL-10	0,5	Il12b	16,21	IL-10	Il12b	16153(Tax:10090)	16160(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IL-10 regulates Il12b expression via histone deacetylation : implications for intestinal macrophage homeostasis .
8711645	0	IL-10	16,21	Interleukin_10	0,14	IL-10	Interleukin 10	3586	3586	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- regulation of tumour necrosis factor alpha -LRB- TNF-alpha -RRB- from human alveolar macrophages and peripheral blood monocytes .
9918218	0	IL-10	16,21	Interleukin_10	0,14	IL-10	Interleukin 10	3586	3586	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- inhibition of primary human prostate cell-induced angiogenesis : IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix_metalloproteinase _ -LRB- MMP -RRB- -2 / MMP-9 secretion .
12847222	0	IL-10	148,153	LFA-1	172,177	IL-10	LFA-1	16153(Tax:10090)	16408(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver _ injury in the presence of TNF-alpha and IL-12 is mediated by IL-10 : a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance .
18326914	0	IL-10	11,16	LOX-1	20,25	IL-10	LOX-1	3586	4973	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of IL-10 on LOX-1 expression of peripheral blood monocytes in patients with acute_coronary_syndrome -RSB- .
23811604	0	IL-10	10,15	LOX-1	19,24	IL-10	LOX-1	3586	4973	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of IL-10 on LOX-1 expression , signalling and functional activity : an atheroprotective response .
21061443	0	IL-10	14,19	Lck	0,3	IL-10	Lck	16153(Tax:10090)	16818(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Lck regulates IL-10 expression in memory-like Th1 cells .
26299622	0	IL-10	26,31	MAPKAP_kinase_2	0,15	IL-10	MAPKAP kinase 2	3586	9261	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MAPKAP_kinase_2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus_infections .
21591983	0	IL-10	40,45	MBL	64,67	IL-10	MBL	3586	50639	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
19109192	0	IL-10	0,5	MD-2	15,19	IL-10	MD-2	3586	23643	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients .
23533666	0	IL-10	19,24	MSK1/2	42,48	IL-10	MSK1/2	16153(Tax:10090)	73086;56613	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers .
19917697	0	IL-10	90,95	Mac-1	40,45	IL-10	Mac-1	16153(Tax:10090)	16409(Tax:10090)	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	Selective down-regulation of neutrophil Mac-1 in endotoxemic_hepatic_microcirculation via IL-10 .
10528169	0	IL-10	48,53	Macrophage_inflammatory_protein-3_beta	0,38	IL-10	Macrophage inflammatory protein-3 beta	3586	6363	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Macrophage_inflammatory_protein-3_beta enhances IL-10 production by activated human peripheral blood monocytes and T cells .
23626014	0	IL-10	40,45	Mammalian_target_of_rapamycin	0,29	IL-10	Mammalian target of rapamycin	3586	2475	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Mammalian_target_of_rapamycin regulates IL-10 and resistance to Pseudomonas_aeruginosa corneal_infection .
17161612	0	IL-10	68,73	NF-kappaB	12,21	IL-10	NF-kappaB	16153(Tax:10090)	18033(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediating|dobj|effects END_ENTITY|acl|mediating	The role of NF-kappaB in mediating the anti-inflammatory effects of IL-10 in intestinal epithelial cells .
18962896	0	IL-10	73,78	NFAT1	49,54	IL-10	NFAT1	16153(Tax:10090)	18019(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	A distal cis-regulatory element , CNS-9 , controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells .
26412089	0	IL-10	71,76	NLRP3	100,105	IL-10	NLRP3	3586	114548	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|Expression Expression|compound|END_ENTITY	Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation .
27074164	0	IL-10	11,16	OPG	46,49	IL-10	OPG	3586	4982	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of IL-10 and glucose on expression of OPG and RANKL in human periodontal ligament fibroblasts .
17144099	0	IL-10	31,36	PDGF-B	50,56	IL-10	PDGF-B	3586	5155	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
25168352	0	IL-10	47,52	RET	33,36	IL-10	RET	16153(Tax:10090)	19713(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The neurotrophic factor receptor RET regulates IL-10 production by in vitro polarised T helper 2 cells .
25825446	0	IL-10	0,5	Rankl	52,57	IL-10	Rankl	16153(Tax:10090)	21943(Tax:10090)	Gene	Gene	Responsiveness|compound|START_ENTITY Responsiveness|nmod|END_ENTITY	IL-10 Critically Modulates B Cell Responsiveness in Rankl - / - Mice .
11241271	0	IL-10	64,69	Regeneration_and_tolerance_factor	0,33	IL-10	Regeneration and tolerance factor	3586	23545	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Regeneration_and_tolerance_factor of the human placenta induces IL-10 production .
24532576	0	IL-10	15,20	S100A8	0,6	IL-10	S100A8	16153(Tax:10090)	20201(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	S100A8 induces IL-10 and protects against acute_lung_injury .
25098409	0	IL-10	87,92	S100A8	20,26	IL-10	S100A8	16153(Tax:10090)	20201(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY END_ENTITY|acl:relcl|requires	TLR9 ligands induce S100A8 in macrophages via a STAT3-dependent pathway which requires IL-10 and PGE2 .
15034082	0	IL-10	39,44	STAT3	15,20	IL-10	STAT3	3586	6774	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of STAT3 for production of IL-10 by colon_carcinoma cells induced by macrophage-derived IL-6 .
15218058	0	IL-10	19,24	STAT3	40,45	IL-10	STAT3	16153(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression .
17575268	0	IL-10	109,114	STAT3	24,29	IL-10	STAT3	3586	6774	Gene	Gene	production|compound|START_ENTITY promote|dobj|production kinases|xcomp|promote END_ENTITY|acl:relcl|kinases	Acute alcohol activates STAT3 , AP-1 , and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes .
18403020	0	IL-10	64,69	STAT3	8,13	IL-10	STAT3	3586	6774	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene .
19096025	0	IL-10	0,5	STAT3	117,122	IL-10	STAT3	16153(Tax:10090)	20848(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|left left|nmod|myocardial_infarction myocardial_infarction|nmod|activation activation|nmod|END_ENTITY	IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial_infarction via activation of STAT3 and suppression of HuR .
20356901	0	IL-10	36,41	STAT3	11,16	IL-10	STAT3	3586	6774	Gene	Gene	down-regulation|compound|START_ENTITY role|nmod|down-regulation role|nmod|END_ENTITY	A role for STAT3 and cathepsin_S in IL-10 down-regulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages .
21286383	0	IL-10	63,68	STAT3	39,44	IL-10	STAT3	3586	6774	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	NDRG2-mediated Modulation of SOCS3 and STAT3 Activity Inhibits IL-10 Production .
21398617	0	IL-10	13,18	STAT3	78,83	IL-10	STAT3	3586	6774	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nmod|activation activation|compound|END_ENTITY	CD5 promotes IL-10 production in chronic_lymphocytic_leukemia B cells through STAT3 and NFAT2 activation .
21654841	0	IL-10	20,25	STAT3	70,75	IL-10	STAT3	3586	6774	Gene	Gene	variant|compound|START_ENTITY permits|nsubj|variant permits|dobj|reduction reduction|nmod|activation activation|compound|END_ENTITY	An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation .
21792878	0	IL-10	85,90	STAT3	24,29	IL-10	STAT3	3586	6774	Gene	Gene	function|compound|START_ENTITY impairment|nmod|function result|nmod|impairment result|nsubj|mutations mutations|nmod|END_ENTITY	SH2-domain mutations in STAT3 in hyper-IgE_syndrome patients result in impairment of IL-10 function .
24513872	0	IL-10	18,23	STAT3	24,29	IL-10	STAT3	16153(Tax:10090)	20848(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Essential role of IL-10 / STAT3 in chronic stress-induced immune suppression .
24577500	0	IL-10	41,46	STAT3	0,5	IL-10	STAT3	3586	6774	Gene	Gene	release|amod|START_ENTITY correlates|nmod|release correlates|nsubj|activation activation|nummod|END_ENTITY	STAT3 activation by KSHV correlates with IL-10 , IL-6 and IL-23 release and an autophagic_block in dendritic cells .
24737107	0	IL-10	47,52	STAT3	13,18	IL-10	STAT3	3586	6774	Gene	Gene	secretion|compound|START_ENTITY controls|dobj|secretion controls|nsubj|END_ENTITY	TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells .
25348624	0	IL-10	60,65	STAT3	89,94	IL-10	STAT3	16153(Tax:10090)	20848(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Interruption of Macrophage-Derived IL-27 -LRB- p28 -RRB- Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3 .
26080800	0	IL-10	72,77	STAT3	0,5	IL-10	STAT3	3586	6774	Gene	Gene	interleukin-10|appos|START_ENTITY associated|nmod|interleukin-10 associated|nsubjpass|activation activation|compound|END_ENTITY	STAT3 activation is associated with cerebrospinal fluid interleukin-10 -LRB- IL-10 -RRB- in primary central nervous system diffuse large B_cell_lymphoma .
26363058	0	IL-10	0,5	STAT3	74,79	IL-10	STAT3	3586	6774	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1 .
26482950	0	IL-10	123,128	STAT3	129,134	IL-10	STAT3	3586	6774	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Tuberculosis is associated with expansion of a motile , permissive and immunomodulatory CD16 -LRB- + -RRB- monocyte population via the IL-10 / STAT3 axis .
24823621	0	IL-10	75,80	Siglec-10	96,105	IL-10	Siglec-10	16153(Tax:10090)	89790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|receptor receptor|compound|END_ENTITY	Pseudaminic_acid on Campylobacter_jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor : a novel flagellin-host interaction .
18325328	0	IL-10	18,23	Siglec-9	0,8	IL-10	Siglec-9	3586	27180	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs .
10903771	0	IL-10	44,49	Stat3	8,13	IL-10	Stat3	3586	6774	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression .
17404258	0	IL-10	0,5	Stat3	95,100	IL-10	Stat3	3586	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3 .
21949832	0	IL-10	14,19	Stat3	97,102	IL-10	Stat3	25325(Tax:10116)	25125(Tax:10116)	Gene	Gene	suppression|compound|START_ENTITY regulates|dobj|suppression regulates|advcl|upregulating upregulating|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Akt regulates IL-10 mediated suppression of TNFa-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation .
25187566	0	IL-10	15,20	Stat3	0,5	IL-10	Stat3	3586	6774	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Stat3 promotes IL-10 expression in lupus_T cells through trans-activation and chromatin remodeling .
26791230	0	IL-10	0,5	Superoxide_Dismutase_1	88,110	IL-10	Superoxide Dismutase 1	16153(Tax:10090)	20655(Tax:10090)	Gene	Gene	Controls|nsubj|START_ENTITY Controls|nmod|END_ENTITY	IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide_Dismutase_1 .
26139429	0	IL-10	32,37	TACI	18,22	IL-10	TACI	3586	23495	Gene	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells .
21601308	0	IL-10	34,39	TGF-b	94,99	IL-10	TGF-b	3586	7040	Gene	Gene	functional|amod|START_ENTITY domain|amod|functional peptide|nmod|domain induces|nsubj|peptide induces|nmod|cells cells|compound|END_ENTITY	A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-b + tolerogenic dendritic cells .
21728174	0	IL-10	33,38	TGF-b	0,5	IL-10	TGF-b	16153(Tax:10090)	21803(Tax:10090)	Gene	Gene	production|compound|START_ENTITY drives|dobj|production drives|nsubj|signaling signaling|compound|END_ENTITY	TGF-b signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE .
24521472	0	IL-10	68,73	TGF-b	74,79	IL-10	TGF-b	3586	7040	Gene	Gene	START_ENTITY|appos|yields yields|nsubj|END_ENTITY	An optimized protocol for human M2 macrophages using M-CSF and IL-4 / IL-10 / TGF-b yields a dominant immunosuppressive phenotype .
27049572	0	IL-10	25,30	TGF-b	18,23	IL-10	TGF-b	3586	7040	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	A study of TNF-a , TGF-b , IL-10 , IL-6 , and IFN-y gene polymorphisms in patients with depression .
24819026	0	IL-10	66,71	TGF-b1	73,79	IL-10	TGF-b1	3586	7040	Gene	Gene	IFN-y|dep|START_ENTITY IFN-y|dep|END_ENTITY	Prognostic importance of single-nucleotide polymorphisms in IL-6 , IL-10 , TGF-b1 , IFN-y , and TNF-a genes in chronic_phase_chronic_myeloid_leukemia .
24974875	0	IL-10	30,35	TGF-b1	22,28	IL-10	TGF-b1	3586	7040	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Association of TNF-a , TGF-b1 , IL-10 , IL-6 , and IFN-y gene polymorphism with acute rejection and infection in lung transplant recipients .
11441082	0	IL-10	73,78	TGF-beta	14,22	IL-10	TGF-beta	3586	7040	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|Regulation Regulation|nmod|response response|amod|END_ENTITY	Regulation of TGF-beta response during T cell activation is modulated by IL-10 .
15848524	0	IL-10	63,68	TGF-beta	36,44	IL-10	TGF-beta	3586	7040	Gene	Gene	MCP-1|dep|START_ENTITY TNF-alpha|dep|MCP-1 TNF-alpha|compound|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
16809410	0	IL-10	8,13	TGF-beta	123,131	IL-10	TGF-beta	16153(Tax:10090)	21803(Tax:10090)	Gene	Gene	attenuates|compound|START_ENTITY pulmonary_fibrosis|nmod|attenuates pulmonary_fibrosis|advcl|inhibiting inhibiting|dobj|production production|nmod|END_ENTITY	In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary_fibrosis by inhibiting the production and activation of TGF-beta in the lung .
17237391	0	IL-10	97,102	TGF-beta	116,124	IL-10	TGF-beta	16153(Tax:10090)	21803(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Naturally occurring lung CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta .
18972297	0	IL-10	0,5	TGF-beta	7,15	IL-10	TGF-beta	3586	7040	Gene	Gene	IL-12|compound|START_ENTITY IL-12|appos|END_ENTITY	IL-10 , TGF-beta , IL-2 , IL-12 , and IFN-gamma cytokine gene polymorphisms in asthma .
7594497	0	IL-10	48,53	TGF-beta	0,8	IL-10	TGF-beta	16153(Tax:10090)	21803(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY ability|acl|produce enhances|dobj|ability enhances|nsubj|END_ENTITY	TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice .
15622443	0	IL-10	22,27	TGF-beta1	11,20	IL-10	TGF-beta1	3586	7040	Gene	Gene	IL-6|amod|START_ENTITY IL-6|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
21591983	0	IL-10	40,45	TGF-beta_1	28,38	IL-10	TGF-beta 1	3586	7040	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
8552986	0	IL-10	130,135	TGF_beta	137,145	IL-10	TGF beta	3586	7040	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
24945737	0	IL-10	22,27	TGFb	16,20	IL-10	TGFb	3586	7040	Gene	Gene	IL-17|appos|START_ENTITY IL-17|compound|END_ENTITY	Serum levels of TGFb , IL-10 , IL-17 , and IL-23 cytokines in b-thalassemia major patients : the impact of silymarin therapy .
18475727	0	IL-10	49,54	TGFbeta	63,70	IL-10	TGFbeta	3586	7040	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Regulation by anti-inflammatory cytokines -LRB- IL-4 , IL-10 , IL-13 , TGFbeta -RRB- of interleukin-8 production by LPS - and / or TNFalpha-activated human polymorphonuclear cells .
11298491	0	IL-10	0,5	TH1	38,41	IL-10	TH1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	mediation|compound|START_ENTITY mediation|nmod|cell cell|compound|END_ENTITY	IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid_dysfunction in polymicrobial sepsis .
1648926	0	IL-10	12,17	TH1	40,43	IL-10	TH1	3586	51497	Gene	Gene	role|nmod|START_ENTITY role|nmod|responses responses|compound|END_ENTITY	The role of IL-10 in crossregulation of TH1 and TH2 responses .
12496489	0	IL-10	6,11	TIMP-1	41,47	IL-10	TIMP-1	3586	7076	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling regulates|dobj|expression expression|compound|END_ENTITY	IL-10 / IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate_tumor lines .
7593617	0	IL-10	0,5	TIMP-1	48,54	IL-10	TIMP-1	3586	7076	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes .
9561025	0	IL-10	73,78	TIMP-1	94,100	IL-10	TIMP-1	16153(Tax:10090)	21857(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
24462705	0	IL-10	41,46	TLR3	0,4	IL-10	TLR3	16153(Tax:10090)	142980(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway .
12417450	0	IL-10	50,55	TNF	64,67	IL-10	TNF	3586	7124	Gene	Gene	START_ENTITY|dep|IFNg IFNg|compound|END_ENTITY	Oral terbutaline differentially affects cytokine -LRB- IL-10 , IL-12 , TNF , IFNg -RRB- release in multiple_sclerosis patients and controls .
18950592	0	IL-10	0,5	TNF	69,72	IL-10	TNF	3586	7124	Gene	Gene	release|compound|START_ENTITY requires|nsubj|release requires|nmod|END_ENTITY	IL-10 release requires stronger toll-like_receptor_4-triggering than TNF : a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp -LRB- 299 -RRB- Gly on IL-10 release .
18950592	0	IL-10	172,177	TNF	69,72	IL-10	TNF	3586	7124	Gene	Gene	release|compound|START_ENTITY Gly|nmod|release TLR4|dobj|Gly requires|parataxis|TLR4 requires|nmod|END_ENTITY	IL-10 release requires stronger toll-like_receptor_4-triggering than TNF : a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp -LRB- 299 -RRB- Gly on IL-10 release .
20805562	0	IL-10	0,5	TNF	53,56	IL-10	TNF	3586	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|elongation elongation|nmod|gene gene|compound|END_ENTITY	IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages .
21805465	0	IL-10	0,5	TNF	38,41	IL-10	TNF	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	limits|nsubj|START_ENTITY limits|dobj|production production|nmod|END_ENTITY	IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-kB p50 member in Trypanosoma congolense_infection-resistant C57BL/6 mice .
24706909	0	IL-10	66,71	TNF	33,36	IL-10	TNF	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY macrophage|nmod|expression macrophage|dobj|production production|compound|END_ENTITY	T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation .
26742960	0	IL-10	166,171	TNF	149,152	IL-10	TNF	3586	7124	Gene	Gene	orchestrated|nmod|START_ENTITY orchestrated|nmod|END_ENTITY	Liver and blood cytokine microenvironment in HCV patients is associated to liver_fibrosis score : a proinflammatory cytokine ensemble orchestrated by TNF and tuned by IL-10 .
7561246	0	IL-10	13,18	TNF	99,102	IL-10	TNF	3586	7124	Gene	Gene	role|nmod|START_ENTITY -LSB-|dobj|role -LSB-|nmod|patients patients|nmod|SIRS SIRS|nmod|relation relation|acl|END_ENTITY	-LSB- The role of IL-10 in patients with SIRS -LRB- systemic_inflammatory_response_syndrome -RRB- -- in relation to TNF activity -RSB- .
8932773	0	IL-10	19,24	TNF	26,29	IL-10	TNF	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|appos|END_ENTITY	Trypanosoma_cruzi : IL-10 , TNF , IFN-gamma , and IL-12 regulate innate and acquired immunity to infection .
21685693	0	IL-10	0,5	TNF-a	46,51	IL-10	TNF-a	3586	7124	Gene	Gene	overexpression|compound|START_ENTITY attenuated|nsubj|overexpression attenuated|dobj|expression expression|nmod|END_ENTITY	IL-10 overexpression attenuated expression of TNF-a and IL-1b activated by lipopolysaccharide in astrocytes .
22845061	0	IL-10	46,51	TNF-a	40,45	IL-10	TNF-a	3586	7124	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Die-off ratio correlates with increased TNF-a : IL-10 ratio and decreased IVF success rates correctable with humira .
23723980	0	IL-10	31,36	TNF-a	24,29	IL-10	TNF-a	3586	7124	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|amod|END_ENTITY	The association between TNF-a , IL-10 gene polymorphisms and primary Sj gren 's syndrome : a meta-analysis and systemic review .
23880295	0	IL-10	0,5	TNF-a	7,12	IL-10	TNF-a	3586	7124	Gene	Gene	IFN-y|compound|START_ENTITY IFN-y|appos|END_ENTITY	IL-10 , TNF-a _ IFN-y : potential early biomarkers for preeclampsia .
24492460	0	IL-10	23,28	TNF-a	0,5	IL-10	TNF-a	3586	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|blockade blockade|amod|END_ENTITY	TNF-a blockade induces IL-10 expression in human CD4 + T cells .
24610932	0	IL-10	68,73	TNF-a	74,79	IL-10	TNF-a	3586	7124	Gene	Gene	associates|nmod|START_ENTITY associates|dep|ratio ratio|amod|END_ENTITY	Immunologic human renal allograft injury associates with an altered IL-10 / TNF-a expression ratio in regulatory B cells .
24974875	0	IL-10	30,35	TNF-a	15,20	IL-10	TNF-a	3586	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|amod|END_ENTITY	Association of TNF-a , TGF-b1 , IL-10 , IL-6 , and IFN-y gene polymorphism with acute rejection and infection in lung transplant recipients .
25978374	0	IL-10	119,124	TNF-a	78,83	IL-10	TNF-a	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	Mechanism|amod|START_ENTITY Expression|nmod|Mechanism Expression|compound|END_ENTITY	Lactobacillus_fermentum ZYL0401 Attenuates Lipopolysaccharide-Induced Hepatic TNF-a Expression and Liver_Injury via an IL-10 - and PGE2-EP4-Dependent Mechanism .
27049572	0	IL-10	25,30	TNF-a	11,16	IL-10	TNF-a	3586	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|amod|END_ENTITY	A study of TNF-a , TGF-b , IL-10 , IL-6 , and IFN-y gene polymorphisms in patients with depression .
10222054	0	IL-10	67,72	TNF-alpha	26,35	IL-10	TNF-alpha	3586	7124	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Preferential induction of TNF-alpha and IL-1beta and inhibition of IL-10 secretion by human peripheral blood monocytes by synthetic aza-alkyl_lysophospholipids .
11034403	0	IL-10	27,32	TNF-alpha	56,65	IL-10	TNF-alpha	3586	7124	Gene	Gene	concomitant|compound|START_ENTITY concomitant|nmod|induction induction|amod|END_ENTITY	Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock_protein_27 -LRB- Hsp27 -RRB- suggests Hsp27 is primarily an antiinflammatory stimulus .
11758205	0	IL-10	66,71	TNF-alpha	50,59	IL-10	TNF-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|mRNA mRNA|amod|END_ENTITY	-LSB- Apoptosis of pancreatic acinar and expression of TNF-alpha mRNA , IL-10 mRNA in rats with acute pancreatitis -RSB- .
11991675	0	IL-10	14,19	TNF-alpha	21,30	IL-10	TNF-alpha	3586	7124	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|appos|END_ENTITY	Production of IL-10 , TNF-alpha , IFN-gamma , TGF-beta1 by different populations of erythroid cells derived from human embryonal liver .
11994432	0	IL-10	34,39	TNF-alpha	55,64	IL-10	TNF-alpha	3586	7124	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|production production|amod|END_ENTITY	Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa_B in primary human macrophages .
11997699	0	IL-10	17,22	TNF-alpha	83,92	IL-10	TNF-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nmod|regulator regulator|nmod|release release|amod|END_ENTITY	Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release .
12759436	0	IL-10	22,27	TNF-alpha	69,78	IL-10	TNF-alpha	3586	7124	Gene	Gene	receptor|compound|START_ENTITY variants|nmod|receptor affect|nsubj|variants affect|dobj|inhibition inhibition|nmod|production production|amod|END_ENTITY	Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production .
12847222	0	IL-10	148,153	TNF-alpha	113,122	IL-10	TNF-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|resistance resistance|nmod|mice mice|nmod|injury injury|nmod|presence presence|nmod|END_ENTITY	Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver _ injury in the presence of TNF-alpha and IL-12 is mediated by IL-10 : a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance .
14707076	0	IL-10	0,5	TNF-alpha	83,92	IL-10	TNF-alpha	3586	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|up-regulation up-regulation|nmod|form form|nmod|END_ENTITY	IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha .
15298427	0	IL-10	125,130	TNF-alpha	102,111	IL-10	TNF-alpha	3586	7124	Gene	Gene	reaction|amod|START_ENTITY reaction|dep|effects effects|nmod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
15603866	0	IL-10	21,26	TNF-alpha	0,9	IL-10	TNF-alpha	3586	7124	Gene	Gene	IL-6|appos|START_ENTITY IL-6|compound|END_ENTITY	TNF-alpha , TGF-beta , IL-10 , IL-6 , and INF-gamma alleles among African Americans and Cuban Americans .
15622443	0	IL-10	22,27	TNF-alpha	0,9	IL-10	TNF-alpha	3586	7124	Gene	Gene	IL-6|amod|START_ENTITY polymorphisms|amod|IL-6 polymorphisms|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
15652410	0	IL-10	125,130	TNF-alpha	51,60	IL-10	TNF-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	production|compound|START_ENTITY increase|nmod|production independent|nmod|increase independent|amod|END_ENTITY	Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1_beta independent of a catecholamine-driven increase in IL-10 production .
15848524	0	IL-10	63,68	TNF-alpha	46,55	IL-10	TNF-alpha	3586	7124	Gene	Gene	MCP-1|dep|START_ENTITY END_ENTITY|dep|MCP-1	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
16781693	0	IL-10	135,140	TNF-alpha	116,125	IL-10	TNF-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|dep|START_ENTITY production|amod|END_ENTITY	Phagocytosis of N-acetyl-D-glucosamine particles , a Th1 adjuvant , by RAW 264.7 cells results in MAPK activation and TNF-alpha , but not IL-10 , production .
16935932	0	IL-10	61,66	TNF-alpha	14,23	IL-10	TNF-alpha	3586	7124	Gene	Gene	suppression|compound|START_ENTITY mediated|nmod|suppression mediated|nsubjpass|destabilization destabilization|amod|END_ENTITY	IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression .
17483704	0	IL-10	27,32	TNF-alpha	0,9	IL-10	TNF-alpha	3586	7124	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|compound|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
19026560	0	IL-10	0,5	TNF-alpha	92,101	IL-10	TNF-alpha	3586	7124	Gene	Gene	overexpression|compound|START_ENTITY affects|nsubj|overexpression affects|nmod|END_ENTITY	IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro .
19097804	0	IL-10	53,58	TNF-alpha	59,68	IL-10	TNF-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Endurance training induces depot-specific changes in IL-10 / TNF-alpha ratio in rat adipose tissue .
19706021	0	IL-10	65,70	TNF-alpha	21,30	IL-10	TNF-alpha	3586	7124	Gene	Gene	levels|compound|START_ENTITY correlated|nmod|levels correlated|nsubj|Maternal Maternal|acl|circulating circulating|dobj|levels levels|amod|END_ENTITY	Maternal circulating TNF-alpha levels are highly correlated with IL-10 levels , but not IL-6 and IL-8 levels , in women with pre-eclampsia .
19948415	0	IL-10	26,31	TNF-alpha	32,41	IL-10	TNF-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	ratio|dep|START_ENTITY ratio|amod|END_ENTITY	Exercise training changes IL-10 / TNF-alpha ratio in the skeletal muscle of post-MI rats .
20055787	0	IL-10	37,42	TNF-alpha	26,35	IL-10	TNF-alpha	3586	7124	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
21591983	0	IL-10	40,45	TNF-alpha	17,26	IL-10	TNF-alpha	3586	7124	Gene	Gene	GPIA|appos|START_ENTITY GPIA|compound|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
7636207	0	IL-10	14,19	TNF-alpha	74,83	IL-10	TNF-alpha	3586	7124	Gene	Gene	expression|compound|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|transcription transcription|nmod|END_ENTITY	Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes .
7897221	1	IL-10	163,168	TNF-alpha	119,128	IL-10	TNF-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	involving|dobj|START_ENTITY mechanism|acl|involving release|nmod|mechanism release|amod|END_ENTITY	Colon-26-derived prostaglandin_E2 inhibits TNF-alpha release via a mechanism involving IL-10 .
8195696	0	IL-10	93,98	TNF-alpha	27,36	IL-10	TNF-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	ability|nmod|START_ENTITY determining|nmod|ability determining|nsubj|effects effects|nmod|END_ENTITY	The cooperative effects of TNF-alpha and IFN-gamma are determining factors in the ability of IL-10 to protect mice from lethal endotoxemia .
8543841	0	IL-10	0,5	TNF-alpha	22,31	IL-10	TNF-alpha	3586	7124	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage .
8708914	0	IL-10	6,11	TNF-alpha	34,43	IL-10	TNF-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY inhibits|nsubj|therapy inhibits|dobj|END_ENTITY	Viral IL-10 gene therapy inhibits TNF-alpha and IL-1_beta , not IL-6 , in the newborn endotoxemic mouse .
8711645	0	IL-10	16,21	TNF-alpha	67,76	IL-10	TNF-alpha	3586	7124	Gene	Gene	regulation|appos|START_ENTITY necrosis|nsubj|regulation necrosis|dep|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- regulation of tumour necrosis factor alpha -LRB- TNF-alpha -RRB- from human alveolar macrophages and peripheral blood monocytes .
8777273	0	IL-10	0,5	TNF-alpha	30,39	IL-10	TNF-alpha	3586	7124	Gene	Gene	synergize|nsubj|START_ENTITY synergize|nmod|END_ENTITY	IL-10 and IL-4 synergize with TNF-alpha to induce IL-1ra production by human neutrophils .
9103430	0	IL-10	40,45	TNF-alpha	82,91	IL-10	TNF-alpha	3586	7124	Gene	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	Contact with T cells modulates monocyte IL-10 production : role of T cell membrane TNF-alpha .
9191887	0	IL-10	155,160	TNF-alpha	169,178	IL-10	TNF-alpha	3586	7124	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9300685	0	IL-10	120,125	TNF-alpha	153,162	IL-10	TNF-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY association|nmod|inhibition association|nmod|levels levels|amod|END_ENTITY	Delay in the onset of systemic_lupus_erythematosus following treatment with the immunomodulator AS101 : association with IL-10 inhibition and increase in TNF-alpha levels .
9328122	0	IL-10	16,21	TNF-alpha	71,80	IL-10	TNF-alpha	3586	7124	Gene	Gene	tumour|amod|START_ENTITY levels|nmod|tumour necrosis|nsubj|levels necrosis|dobj|receptors receptors|appos|END_ENTITY	Serum levels of IL-10 , IL-15 and soluble tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- receptors in type C chronic liver_disease .
9415530	0	IL-10	19,24	TNF-alpha	44,53	IL-10	TNF-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Gene expression of IL-10 in relationship to TNF-alpha , IL-1beta and IL-2 in the rat brain following middle_cerebral_artery_occlusion .
17483704	0	IL-10	27,32	TNF-beta	11,19	IL-10	TNF-beta	3586	4049	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
12616343	0	IL-10	213,218	TNF_alpha	176,185	IL-10	TNF alpha	3586	7124	Gene	Gene	blockage|nmod|START_ENTITY blockage|nsubj|suppression suppression|nmod|END_ENTITY	IL-18 initiates release of matrix_metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1 : suppression by TNF_alpha blockage and modulation by IL-10 .
8552986	0	IL-10	130,135	TNF_alpha	147,156	IL-10	TNF alpha	3586	7124	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
24816983	0	IL-10	84,89	TNFa	57,61	IL-10	TNFa	3586	7124	Gene	Gene	overexpression|compound|START_ENTITY effects|nmod|overexpression Regulation|dep|effects Regulation|nmod|mediators mediators|nmod|END_ENTITY	Regulation of osteoarthritis-associated key mediators by TNFa and IL-10 : effects of IL-10 overexpression in human synovial fibroblasts and a synovial cell line .
25384561	0	IL-10	4,9	TNFa	10,14	IL-10	TNFa	3586	7124	Gene	Gene	START_ENTITY|dep|Ratio Ratio|compound|END_ENTITY	Low IL-10 / TNFa Ratio in Patients with Coronary_Artery_Disease and Reduced Left Ventricular Ejection Fraction with a Poor Prognosis After 10 Years .
10723680	0	IL-10	19,24	Th1	71,74	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	Chronic_colitis|nmod|START_ENTITY Chronic_colitis|dep|regulation regulation|nmod|response response|amod|END_ENTITY	Chronic_colitis in IL-10 - / - mice : insufficient counter regulation of a Th1 response .
10754317	0	IL-10	26,31	Th1	110,113	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Suppression|nmod|expression enhances|nsubj|Suppression enhances|nmod|induction induction|amod|END_ENTITY	Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction : potential for cellular vaccine development .
11591763	0	IL-10	43,48	Th1	68,71	IL-10	Th1	3586	51497	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|amod|END_ENTITY	Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells .
11908705	0	IL-10	35,40	Th1	0,3	IL-10	Th1	3586	51497	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Th1 and Th2 cytokine modulation by IL-10 / IL-12 imbalance in autoimmune_haemolytic_anaemia -LRB- AIHA -RRB- .
11937584	0	IL-10	26,31	Th1	69,72	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY correlates|nsubj|induction correlates|nmod|switch switch|nmod|END_ENTITY	Preferential induction of IL-10 in APC correlates with a switch from Th1 to Th2 response following infection with a low pathogenic variant of Theiler 's _ virus .
11971021	0	IL-10	62,67	Th1	198,201	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	kinases|nmod|START_ENTITY Role|nmod|kinases Role|dep|role role|nmod|extracellular_signal-regulated_kinase extracellular_signal-regulated_kinase|nmod|loop loop|nmod|response response|compound|END_ENTITY	Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production : central role of extracellular_signal-regulated_kinase in the negative feedback loop of the CpG DNA-mediated Th1 response .
14635055	0	IL-10	83,88	Th1	54,57	IL-10	Th1	3586	51497	Gene	Gene	production|compound|START_ENTITY stimulating|dobj|production suppresses|advcl|stimulating suppresses|dobj|responses responses|amod|END_ENTITY	Hepatitis_C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes .
15162438	0	IL-10	37,42	Th1	98,101	IL-10	Th1	3586	51497	Gene	Gene	modulation|nmod|START_ENTITY enhances|nsubj|modulation enhances|dobj|response response|amod|END_ENTITY	Small interference RNA modulation of IL-10 in human monocyte-derived dendritic cells enhances the Th1 response .
15585882	0	IL-10	0,5	Th1	83,86	IL-10	Th1	3586	51497	Gene	Gene	released|nsubj|START_ENTITY released|dobj|induction induction|nmod|subset subset|nmod|cytokines cytokines|amod|END_ENTITY	IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells .
16014524	0	IL-10	31,36	Th1	45,48	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Differential regulation of the IL-10 gene in Th1 and Th2 T cells .
16751369	0	IL-10	111,116	Th1	35,38	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	reactivation|compound|START_ENTITY signaling|dobj|reactivation mediating|advcl|signaling regulates|advcl|mediating regulates|dobj|immunity immunity|amod|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
16751369	0	IL-10	61,66	Th1	35,38	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	mediating|dobj|START_ENTITY regulates|advcl|mediating regulates|dobj|immunity immunity|amod|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
1680917	0	IL-10	14,19	Th1	77,80	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	lymphocytes|amod|START_ENTITY Production|nmod|lymphocytes correlates|nsubj|Production correlates|nmod|down-regulation down-regulation|nmod|synthesis synthesis|amod|END_ENTITY	Production of IL-10 by CD4 + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth_infection .
16917957	0	IL-10	32,37	Th1	67,70	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	sources|nmod|START_ENTITY sources|nmod|END_ENTITY	Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo .
19058879	0	IL-10	68,73	Th1	0,3	IL-10	Th1	3586	51497	Gene	Gene	responses|compound|START_ENTITY convert|nmod|responses convert|nsubj|responses responses|amod|END_ENTITY	Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer 's _ disease .
19941850	0	IL-10	60,65	Th1	22,25	IL-10	Th1	3586	51497	Gene	Gene	production|compound|START_ENTITY influencing|dobj|production polarization|acl|influencing polarization|amod|END_ENTITY	Cryptomerione induces Th1 cell polarization via influencing IL-10 production by cholera toxin-primed dendritic cells .
21061443	0	IL-10	14,19	Th1	46,49	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Lck regulates IL-10 expression in memory-like Th1 cells .
21531623	0	IL-10	50,55	Th1	4,7	IL-10	Th1	3586	51497	Gene	Gene	switching|compound|START_ENTITY IFN-y|nmod|switching control|nmod|IFN-y cycle|dep|control cycle|amod|END_ENTITY	The Th1 life cycle : molecular control of IFN-y to IL-10 switching .
21728174	0	IL-10	33,38	Th1	62,65	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	production|compound|START_ENTITY drives|dobj|production drives|nmod|cells cells|amod|END_ENTITY	TGF-b signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE .
22266280	0	IL-10	42,47	Th1	62,65	IL-10	Th1	3586	51497	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells .
23028054	7	IL-10	1210,1215	Th1	1257,1260	IL-18	Th1	3606	51497	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cultures cultures|amod|END_ENTITY	Interestingly , E4BP4 gene expression and the percentage of E4BP4 -LRB- + -RRB- cells of the recently shown IL-10 transcriptional regulator E4BP4 correlated with IL-10 gene expression and protein secretion in Th1 cultures .
23828573	0	IL-10	29,34	Th1	40,43	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	ifn-y-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal_cord_injury .
24120849	0	IL-10	112,117	Th1	67,70	IL-10	Th1	3586	51497	Gene	Gene	IL-4|dep|START_ENTITY cytokines|appos|IL-4 _|dobj|cytokines _|nsubj|analysis analysis|nmod|END_ENTITY	Cloning and sequence analysis of Peromyscus yucatanicus -LRB- Rodentia -RRB- Th1 -LRB- IL-12p35 , IFN-y_and_TNF -RRB- _ and_Th2 -LRB- IL-4 , IL-10 and TGF-b -RRB- cytokines .
25225664	0	IL-10	14,19	Th1	38,41	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY enhances|nsubj|blockade enhances|dobj|END_ENTITY	Early or late IL-10 blockade enhances Th1 and th17 effector responses and promotes fungal clearance in mice with cryptococcal_lung_infection .
26417443	0	IL-10	84,89	Th1	37,40	IL-10	Th1	3586	51497	Gene	Gene	correlates|compound|START_ENTITY expressing|dobj|correlates mediated|xcomp|expressing mediated|dobj|expansion expansion|nmod|END_ENTITY	IL-27 and TGFb mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary_tuberculosis .
8419468	0	IL-10	6,11	Th1	47,50	IL-10	Th1	3586	51497	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|helper helper|appos|END_ENTITY	Human IL-10 is produced by both type 1 helper -LRB- Th1 -RRB- and type 2 helper -LRB- Th2 -RRB- T cell clones and inhibits their antigen-specific proliferation and cytokine production .
9834110	0	IL-10	0,5	Th1	48,51	IL-10	Th1	16153(Tax:10090)	57314(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|responses responses|amod|END_ENTITY	IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida_albicans infection .
11997699	0	IL-10	17,22	Thrombin	0,8	IL-10	Thrombin	25325(Tax:10116)	29251(Tax:10116)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release .
18195725	0	IL-10	47,52	Toll-like_receptor_2	0,20	IL-10	Toll-like receptor 2	3586	7097	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Toll-like_receptor_2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu .
19542371	0	IL-10	89,94	Tristetraprolin	0,15	IL-10	Tristetraprolin	16153(Tax:10090)	22695(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10 .
16751369	0	IL-10	111,116	Tyk2	0,4	IL-10	Tyk2	16153(Tax:10090)	54721(Tax:10090)	Gene	Gene	reactivation|compound|START_ENTITY signaling|dobj|reactivation mediating|advcl|signaling regulates|advcl|mediating regulates|nsubj|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
16751369	0	IL-10	61,66	Tyk2	0,4	IL-10	Tyk2	16153(Tax:10090)	54721(Tax:10090)	Gene	Gene	mediating|dobj|START_ENTITY regulates|advcl|mediating regulates|nsubj|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
24403534	0	IL-10	39,44	aryl_hydrocarbon_receptor	4,29	IL-10	aryl hydrocarbon receptor	16153(Tax:10090)	11622(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor promotes IL-10 production by NK cells .
15749884	0	IL-10	65,70	c-Maf	18,23	IL-10	c-Maf	3586	4094	Gene	Gene	expression|compound|START_ENTITY factor|nmod|expression factor|nsubj|END_ENTITY	The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages .
19414776	0	IL-10	16,21	c-Maf	0,5	IL-10	c-Maf	3586	4094	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	c-Maf regulates IL-10 expression during Th17 polarization .
15219461	0	IL-10	99,104	cyclooxygenase-2	35,51	IL-10	cyclooxygenase-2	3586	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of IL-6 , TNF-alpha , and cyclooxygenase-2 protein expression by prostaglandin_E2-induced IL-10 in bone marrow-derived dendritic cells .
26416211	0	IL-10	15,20	cyclooxygenase-2	82,98	IL-10	cyclooxygenase-2	16153(Tax:10090)	19225(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|nmod|END_ENTITY	Suppression of IL-10 production by activated B cells via a cell contact-dependent cyclooxygenase-2 pathway upregulated in IFN-y-treated mesenchymal stem cells .
15538736	0	IL-10	27,32	galectin-1	8,18	IL-10	galectin-1	3586	3956	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Dimeric galectin-1 induces IL-10 production in T-lymphocytes : an important tool in the regulation of the immune response .
16581128	0	IL-10	18,23	galectin-1	48,58	IL-10	galectin-1	3586	3956	Gene	Gene	production|compound|START_ENTITY production|acl|using using|dobj|homodimers homodimers|amod|END_ENTITY	Strongly enhanced IL-10 production using stable galectin-1 homodimers .
21191065	0	IL-10	97,102	galectin-1	20,30	IL-10	galectin-1	3586	3956	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Lung_cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor_of_DNA_binding_3 / IL-10 signaling pathway .
25078297	0	IL-10	0,5	gp120	86,91	IL-10	gp120	3586	3700	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|neuropathic_pain neuropathic_pain|acl|induced induced|nmod|HIV HIV|nummod|END_ENTITY	IL-10 mediated by herpes simplex virus vector reduces neuropathic_pain induced by HIV gp120 combined with ddC in rats .
7511078	0	IL-10	26,31	gp120	12,17	IL-10	gp120	3586	3700	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells ; correlation with the induction of other cytokines .
10898750	0	IL-10	44,49	iNOS	50,54	IL-10	iNOS	16153(Tax:10090)	18126(Tax:10090)	Gene	Gene	/|compound|START_ENTITY chronic_colitis|nmod|/ END_ENTITY|nsubj|chronic_colitis	Spontaneously developing chronic_colitis in IL-10 / iNOS double-deficient mice .
11406467	0	IL-10	39,44	iNOS	64,68	IL-10	iNOS	16153(Tax:10090)	18126(Tax:10090)	Gene	Gene	actions|nmod|START_ENTITY independent|nsubj|actions independent|nmod|END_ENTITY	Cardioprotective actions of endogenous IL-10 are independent of iNOS .
18565249	0	IL-10	55,60	iNOS	10,14	IL-10	iNOS	3586	51477	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage .
18991287	0	IL-10	65,70	iNOS	31,35	IL-10	iNOS	16153(Tax:10090)	18126(Tax:10090)	Gene	Gene	formation|compound|START_ENTITY repression|nmod|formation expression|nmod|repression END_ENTITY|dobj|expression	Nramp1-functionality increases iNOS expression via repression of IL-10 formation .
9555975	0	IL-10	12,17	iNOS	21,25	IL-10	iNOS	281246(Tax:9913)	282876(Tax:9913)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of IL-10 in iNOS and cytokine mRNA expression during in vitro differentiation of bovine mononuclear phagocytes .
10376939	0	IL-10	50,55	interleukin-10	34,48	IL-10	interleukin-10	3586	3586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Markers in the promoter region of interleukin-10 -LRB- IL-10 -RRB- gene in myasthenia_gravis : implications of diverse effects of IL-10 in the pathogenesis of the disease .
11338880	0	IL-10	36,41	interleukin-10	20,34	IL-10	interleukin-10	3586	3586	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Comparison of serum interleukin-10 -LRB- IL-10 -RRB- levels between normal volunteers and patients with advanced melanoma .
11709312	0	IL-10	177,182	interleukin-10	161,175	IL-10	interleukin-10	3586	3586	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Activation by 9 - -LRB- R -RRB- - -LSB- 2 - -LRB- phosphonomethoxy -RRB- propyl -RSB- adenine of chemokine -LRB- RANTES , macrophage_inflammatory_protein_1alpha -RRB- and cytokine -LRB- tumor_necrosis_factor_alpha , interleukin-10 -LSB- IL-10 -RSB- , IL-1beta -RRB- production .
11810532	0	IL-10	26,31	interleukin-10	10,24	IL-10	interleukin-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin-10 -LRB- IL-10 -RRB- on experimental LPS-induced acute_lung_injury .
11956022	0	IL-10	157,162	interleukin-10	141,155	IL-10	interleukin-10	3586	3586	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The combination of the interleukin-1alpha -LRB- IL-1alpha-889 -RRB- genotype and the interleukin-10 -LRB- IL-10 ATA -RRB- haplotype is associated with increased interleukin-10 -LRB- IL-10 -RRB- plasma levels in healthy individuals .
1433975	0	IL-10	81,86	interleukin-10	65,79	IL-10	interleukin-10	3586	3586	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Function , molecular structure and gene expression regulation of interleukin-10 -LRB- IL-10 -RRB- -RSB- .
14682393	0	IL-10	43,48	interleukin-10	27,41	IL-10	interleukin-10	3586	3586	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	A base substitution in the interleukin-10 -LRB- IL-10 -RRB- promoter between Sp1 and ets-1 binding sites is not associated with variation of IL-10 levels .
15319176	0	IL-10	93,98	interleukin-10	77,91	IL-10	interleukin-10	3586	3586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A three base pair gene variation within the distal 5 ' - flanking region of the interleukin-10 -LRB- IL-10 -RRB- gene is related to the in vitro IL-10 production capacity of lipopolysaccharide-stimulated peripheral blood mononuclear cells .
19591971	0	IL-10	60,65	interleukin-10	44,58	IL-10	interleukin-10	3586	3586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the promoter region of the interleukin-10 -LRB- IL-10 -RRB- gene in women with cervical_insufficiency .
22393041	0	IL-10	178,183	interleukin-10	162,176	IL-10	interleukin-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Protein kinase C -LRB- PKC -RRB- - extracellular_signal-regulated_kinase_1 / 2 -LRB- ERK1/2 -RRB- signaling cascade regulates glycogen synthase_kinase-3 _ -LRB- GSK-3 -RRB- inhibition-mediated interleukin-10 -LRB- IL-10 -RRB- expression in lipopolysaccharide -LRB- LPS -RRB- - induced endotoxemia .
27016017	0	IL-10	24,29	interleukin-10	8,22	IL-10	interleukin-10	25325(Tax:10116)	25325(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of interleukin-10 -LRB- IL-10 -RRB- in regulation of GABAergic transmission and acute response to ethanol .
7836946	0	IL-10	41,46	interleukin-10	25,39	IL-10	interleukin-10	3586	3586	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Intrathecal synthesis of interleukin-10 -LRB- IL-10 -RRB- in viral and inflammatory_diseases_of_the_central_nervous_system .
8178456	0	IL-10	59,64	interleukin-10	43,57	IL-10	interleukin-10	3586	3586	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of viral and human interleukin-10 -LRB- IL-10 -RRB- by primary B cell tumors and B cell lines .
9234213	0	IL-10	31,36	interleukin-10	15,29	IL-10	interleukin-10	3586	3586	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Amniotic fluid interleukin-10 -LRB- IL-10 -RRB- concentrations during pregnancy and with labor .
9373262	0	IL-10	28,33	interleukin-10	12,26	IL-10	interleukin-10	3586	3586	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of interleukin-10 -LRB- IL-10 -RRB- in IL-15-mediated T-cell responses .
9728752	0	IL-10	45,50	interleukin-10	29,43	IL-10	interleukin-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Time-dependent expression of interleukin-10 -LRB- IL-10 -RRB- mRNA during the early phase of skin wound healing as a possible indicator of wound vitality .
16982608	0	IL-10	78,83	interleukin-10_receptor_2	31,56	IL-10	interleukin-10 receptor 2	3586	3588	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Conformational changes mediate interleukin-10_receptor_2 -LRB- IL-10R2 -RRB- binding to IL-10 and assembly of the signaling complex .
23545299	0	IL-10	67,72	interleukin-4	45,58	IL-10	interleukin-4	16153(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY induce|dobj|T induce|iobj|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
1421000	0	IL-10	28,33	interleukin_10	12,26	IL-10	interleukin 10	3586	3586	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of interleukin_10 -LRB- IL-10 -RRB- in the ascites of patients with ovarian and other intra-abdominal_cancers .
23069299	0	IL-10	67,72	interleukin_10	51,65	IL-10	interleukin 10	3586	3586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of tumor_necrosis_factor_a -LRB- TNF-a -RRB- and interleukin_10 -LRB- IL-10 -RRB- gene polymorphisms in dermatomyositis patients : a pilot study .
7594602	0	IL-10	68,73	macrophage_inflammatory_protein-1_alpha	14,53	IL-10	macrophage inflammatory protein-1 alpha	3586	6348	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of macrophage_inflammatory_protein-1_alpha expression by IL-10 .
20435894	0	IL-10	0,5	miR-155	15,22	IL-10	miR-155	3586	406947	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	IL-10 inhibits miR-155 induction by toll-like receptors .
25381386	0	IL-10	0,5	miR-155	41,48	IL-10	miR-155	3586	406947	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	IL-10 regulates Aicda expression through miR-155 .
24835395	0	IL-10	68,73	miR-27a	0,7	IL-10	miR-27a	3586	407018	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-27a regulates inflammatory response of macrophages by targeting IL-10 .
11994432	0	IL-10	34,39	p38	112,115	IL-10	p38	3586	1432	Gene	Gene	suppression|compound|START_ENTITY mechanism|nmod|suppression mechanism|acl:relcl|involve involve|dobj|inhibition inhibition|nmod|protein protein|amod|END_ENTITY	Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa_B in primary human macrophages .
16935932	0	IL-10	61,66	p38	82,85	IL-10	p38	3586	1432	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|activation activation|amod|END_ENTITY	IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression .
17202341	0	IL-10	0,5	p38	134,137	IL-10	p38	3586	1432	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|involvement involvement|nmod|MAPK MAPK|compound|END_ENTITY	IL-10 regulation by HIV-Tat in primary human monocytic cells : involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors .
20671651	0	IL-10	40,45	p38	10,13	IL-10	p38	3586	1432	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	High MAPK p38 activity and low level of IL-10 in intermittent_claudication as opposed to stable_angina .
22829768	0	IL-10	73,78	p38	54,57	IL-10	p38	3586	1432	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	The pore-forming toxin b hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity .
23901045	0	IL-10	206,211	p38	168,171	IL-10	p38	3586	1432	Gene	Gene	suppressing|dobj|START_ENTITY enhances|dep|suppressing enhances|nsubj|inhibition inhibition|nmod|END_ENTITY	Novel function for the p38-MK2 signaling pathway in circulating CD1c + -LRB- BDCA-1 + -RRB- myeloid dendritic cells from healthy donors and advanced cancer patients ; inhibition of p38 enhances IL-12 whilst suppressing IL-10 .
9551930	0	IL-10	23,28	p38	85,88	IL-10	p38	3586	1432	Gene	Gene	synthesis|compound|START_ENTITY Regulation|nmod|synthesis Regulation|dep|role role|nmod|END_ENTITY	Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha : role of the p38 and p42/44 mitogen-activated protein kinases .
23410504	0	IL-10	0,5	serotonin_transporter	16,37	IL-10	serotonin transporter	3586	6532	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	IL-10 modulates serotonin_transporter activity and molecular expression in intestinal epithelial cells .
12947725	0	IL-10	41,46	somatostatin	11,23	IL-10	somatostatin	25325(Tax:10116)	24797(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	-LSB- Effect of somatostatin on modulation of IL-10 and TGF-beta_1 during acute pancreatitis -RSB- .
17114447	0	IL-10	0,5	suppressor_of_cytokine_signaling-3	84,118	IL-10	suppressor of cytokine signaling-3	3586	9021	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor_of_cytokine_signaling-3 .
17393023	0	IL-10	9,14	thrombin	68,76	IL-10	thrombin	3586	2147	Gene	Gene	produced|nsubj|START_ENTITY produced|xcomp|lipopolysaccharide lipopolysaccharide|dobj|generation generation|compound|END_ENTITY	Monocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles .
8683105	0	IL-10	0,5	tumor_necrosis_factor-alpha	84,111	IL-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	production|compound|START_ENTITY enhanced|nsubjpass|production enhanced|nmod|END_ENTITY	IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor_necrosis_factor-alpha .
11709312	0	IL-10	177,182	tumor_necrosis_factor_alpha	132,159	IL-10	tumor necrosis factor alpha	3586	7124	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|dep|-RSB-	Activation by 9 - -LRB- R -RRB- - -LSB- 2 - -LRB- phosphonomethoxy -RRB- propyl -RSB- adenine of chemokine -LRB- RANTES , macrophage_inflammatory_protein_1alpha -RRB- and cytokine -LRB- tumor_necrosis_factor_alpha , interleukin-10 -LSB- IL-10 -RSB- , IL-1beta -RRB- production .
7954438	0	IL-10	158,163	tumor_necrosis_factor_alpha	165,192	IL-10	tumor necrosis factor alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
7543512	0	IL-10	0,5	tyk2	46,50	IL-10	tyk2	3586	7297	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes .
17289164	0	IL-10	14,19	upstream_stimulating_factor	34,61	IL-10	upstream stimulating factor	3586	7391	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of IL-10 expression by upstream_stimulating_factor -LRB- USF-1 -RRB- in glioma-associated microglia .
10657629	0	IL-10-related_T_cell-derived_inducible_factor	32,77	IL-10	129,134	IL-10-related T cell-derived inducible factor	IL-10	50616	3586	Gene	Gene	Cloning|nmod|START_ENTITY cytokine|advcl|Cloning cytokine|xcomp|related related|nmod|END_ENTITY	Cloning and characterization of IL-10-related_T_cell-derived_inducible_factor -LRB- IL-TIF -RRB- , a novel cytokine structurally related to IL-10 and inducible by IL-9 .
11035029	0	IL-10-related_T_cell-derived_inducible_factor	153,198	IL-10	136,141	IL-10-related T cell-derived inducible factor	IL-10	50616	3586	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Identification of the functional interleukin-22 -LRB- IL-22 -RRB- receptor complex : the IL-10R2 chain -LRB- IL-10Rbeta -RRB- is a common chain of both the IL-10 and IL-22 -LRB- IL-10-related_T_cell-derived_inducible_factor , IL-TIF -RRB- receptor complexes .
15123776	0	IL-10R2	75,82	IL-10_receptor-2	57,73	IL-10R2	IL-10 receptor-2	3588	3588	Gene	Gene	cytokines|appos|START_ENTITY cytokines|dep|END_ENTITY	The expanded family of class II cytokines that share the IL-10_receptor-2 -LRB- IL-10R2 -RRB- chain .
20232770	0	IL-10RA	39,46	Interleukin_10_receptor_alpha_subunit	0,37	IL-10RA	Interleukin 10 receptor alpha subunit	3587	3587	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin_10_receptor_alpha_subunit -LRB- IL-10RA -RRB- gene polymorphism and IL-10 serum levels in Egyptian atopic patients .
15123776	0	IL-10_receptor-2	57,73	IL-10R2	75,82	IL-10 receptor-2	IL-10R2	3588	3588	Gene	Gene	cytokines|dep|START_ENTITY cytokines|appos|END_ENTITY	The expanded family of class II cytokines that share the IL-10_receptor-2 -LRB- IL-10R2 -RRB- chain .
16457848	0	IL-11	14,19	COX-2	0,5	IL-11	COX-2	3589	5743	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	COX-2 induces IL-11 production in human breast_cancer cells .
7696971	0	IL-11	0,5	IL-11	55,60	IL-11	IL-11	171040(Tax:10116)	171040(Tax:10116)	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	IL-11 , a pleiotropic cytokine : exciting new effects of IL-11 on gastrointestinal_mucosal biology .
7696971	0	IL-11	55,60	IL-11	0,5	IL-11	IL-11	171040(Tax:10116)	171040(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	IL-11 , a pleiotropic cytokine : exciting new effects of IL-11 on gastrointestinal_mucosal biology .
8133053	0	IL-11	74,79	IL-1_and_transforming_growth_factor-beta	0,40	IL-11	IL-1 and transforming growth factor-beta	3589	3553;7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	IL-1_and_transforming_growth_factor-beta regulation of fibroblast-derived IL-11 .
8647228	0	IL-11	41,46	IL-3	89,93	IL-11	IL-3	16156(Tax:10090)	16187(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY IL-4|nmod|combination reverses|nsubj|IL-4 reverses|dobj|effect effect|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- in combination with IL-11 or IL-6 reverses the inhibitory effect of IL-3 on early B lymphocyte development .
8943559	0	IL-11	0,5	IL-3	22,26	IL-11	IL-3	16156(Tax:10090)	16187(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IL-11 synergizes with IL-3 in promoting the recovery of the immune system after irradiation .
8647228	0	IL-11	41,46	IL-4	15,19	IL-11	IL-4	16156(Tax:10090)	16189(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interleukin-4 -LRB- IL-4 -RRB- in combination with IL-11 or IL-6 reverses the inhibitory effect of IL-3 on early B lymphocyte development .
11022130	0	IL-11	120,125	IL-6	76,80	IL-11	IL-6	3589	3569	Gene	Gene	interleukin-11|appos|START_ENTITY IL-6|appos|interleukin-11 cytokines|dep|IL-6 cytokines|amod|interleukin-6 interleukin-6|dep|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11022130	0	IL-11	120,125	IL-6	98,102	IL-11	IL-6	3589	3569	Gene	Gene	interleukin-11|appos|START_ENTITY END_ENTITY|appos|interleukin-11	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11517162	0	IL-11	26,31	IL-6	0,4	IL-11	IL-6	3589	3569	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	IL-6 negatively regulates IL-11 production in vitro and in vivo .
25929737	0	IL-11	80,85	MTA2	0,4	IL-11	MTA2	3589	9219	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	MTA2 enhances colony formation and tumor growth of gastric_cancer cells through IL-11 .
20640990	0	IL-11	10,15	TGF-beta	44,52	IL-11	TGF-beta	171040(Tax:10116)	59086(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of IL-11 on glomerular expression of TGF-beta and extracellular matrix in nephrotoxic_nephritis in Wistar Kyoto rats .
22568077	0	IL-11	26,31	TRPV1	55,60	IL-11	TRPV1	3589	7442	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	-LSB- Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells -RSB- .
12679933	0	IL-11	0,5	Tie-2	19,24	IL-11	Tie-2	171040(Tax:10116)	89804(Tax:10116)	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	IL-11 up-regulates Tie-2 expression during the healing of gastric_ulcers in rats .
14720445	0	IL-11	22,27	Tpo	11,14	IL-11	Tpo	3589	7173	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Effect of Tpo and/or IL-11 gene modified stromal cells on the expansion of CD34 + CD38 - hematopoietic primitive progenitor cells -RSB- .
19913506	0	IL-11	0,5	interferon-gamma	62,78	IL-11	interferon-gamma	3589	3458	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	IL-11 expression in retinal and corneal cells is regulated by interferon-gamma .
15381181	0	IL-11	27,32	interleukin-11	11,25	IL-11	interleukin-11	3589	3589	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Endogenous interleukin-11 -LRB- IL-11 -RRB- levels in newly diagnosed children with acquired severe_aplastic_anemia -LRB- SAA -RRB- .
8807086	0	IL-11	27,32	interleukin-11	11,25	IL-11	interleukin-11	171040(Tax:10116)	171040(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Endogenous interleukin-11 -LRB- IL-11 -RRB- expression is increased and prophylactic use of exogenous IL-11 enhances platelet recovery and improves survival during thrombocytopenia associated with experimental group B streptococcal_sepsis in neonatal rats .
8940087	0	IL-11	55,60	interleukin-11	39,53	IL-11	interleukin-11	3589	3589	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Functional expression of soluble human interleukin-11 -LRB- IL-11 -RRB- receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130 .
11022130	0	IL-11	120,125	interleukin-6	61,74	IL-11	interleukin-6	3589	3569	Gene	Gene	interleukin-11|appos|START_ENTITY IL-6|appos|interleukin-11 cytokines|dep|IL-6 cytokines|amod|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
10843767	0	IL-11	27,32	interleukin_11	11,25	IL-11	interleukin 11	171040(Tax:10116)	171040(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin_11 -LRB- IL-11 -RRB- on early post-implantation development of the rat .
7743551	0	IL-12	57,62	AK-5	0,4	IL-12	AK-5	64546(Tax:10116)	301115(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	AK-5 tumor-induced expression of interleukin-12 : role of IL-12 in NK-mediated AK-5 regression .
7947460	0	IL-12	0,5	IFN-gamma	26,35	IL-12	IFN-gamma	64546(Tax:10116)	3458	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4 + allergen-specific Th2 T cell clones .
18262271	0	IL-12	65,70	IL-10	71,76	IL-12	IL-10	64546(Tax:10116)	25325(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	CD40L stimulation of rat dendritic cells specifically favors the IL-12 / IL-10 ratio resulting in a strong T cell stimulatory capacity .
18231731	0	IL-12	41,46	TGF-beta1	10,19	IL-12	TGF-beta1	64546(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of TGF-beta1 on the expression of IL-12 , IL-15 , IL-18 , IL-4 and IL-10 in heart transplantation rejection in rats .
22740240	0	IL-12A	38,44	IL-12B	46,52	IL-12A	IL-12B	3592	3593	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Associations between polymorphisms in IL-12A , IL-12B , IL-12Rb1 , IL-27 gene and serum levels of IL-12p40 , IL-27p28 with esophageal_cancer .
22740240	0	IL-12A	38,44	IL-12Rb1	54,62	IL-12A	IL-12Rb1	3592	3594	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Associations between polymorphisms in IL-12A , IL-12B , IL-12Rb1 , IL-27 gene and serum levels of IL-12p40 , IL-27p28 with esophageal_cancer .
22740240	0	IL-12A	38,44	IL-27	64,69	IL-12A	IL-27	3592	246778	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Associations between polymorphisms in IL-12A , IL-12B , IL-12Rb1 , IL-27 gene and serum levels of IL-12p40 , IL-27p28 with esophageal_cancer .
22740240	0	IL-12B	46,52	IL-12A	38,44	IL-12B	IL-12A	3593	3592	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Associations between polymorphisms in IL-12A , IL-12B , IL-12Rb1 , IL-27 gene and serum levels of IL-12p40 , IL-27p28 with esophageal_cancer .
16005098	0	IL-12B	24,30	Interleukin-12p40	0,17	IL-12B	Interleukin-12p40	3593	3593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin-12p40 gene -LRB- IL-12B -RRB- polymorphism and Type_1_diabetes_mellitus in Japanese : possible role in subjects without having high-risk HLA haplotypes .
18485489	0	IL-12B	63,69	interleukin-12p40	39,56	IL-12B	interleukin-12p40	3593	3593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 3 ` UTR 1188_A / C polymorphism in the interleukin-12p40 gene -LRB- IL-12B -RRB- is associated with lepromatous_leprosy in the west of Mexico .
22740240	0	IL-12Rb1	54,62	IL-12A	38,44	IL-12Rb1	IL-12A	3594	3592	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Associations between polymorphisms in IL-12A , IL-12B , IL-12Rb1 , IL-27 gene and serum levels of IL-12p40 , IL-27p28 with esophageal_cancer .
18726352	0	IL-12_p40	63,72	IFN-gamma	20,29	IL-12 p40	IFN-gamma	16160(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Promoting effect of IFN-gamma on the expression of LPS-induced IL-12_p40 and p35 mRNA in murine suppressor macrophages .
15821753	0	IL-12p40	60,68	IL-10	111,116	IL-12p40	IL-10	16160(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|parataxis|kinase kinase|nsubj|role role|nmod|END_ENTITY	Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages : role of IL-10 and ERK1/2 kinase signaling .
9665281	0	IL-12p40	39,47	IL-10	62,67	IL-12p40	IL-10	16160(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-beta in ANA-1 cells .
23065757	0	IL-12p40	15,23	Klf10	0,5	IL-12p40	Klf10	16160(Tax:10090)	21847(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Klf10 inhibits IL-12p40 production in macrophage_colony-stimulating_factor-induced mouse bone marrow-derived macrophages .
20145200	0	IL-12p40	68,76	SHP-1	29,34	IL-12p40	SHP-1	16160(Tax:10090)	15170(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase .
21730055	0	IL-12p40	84,92	interleukin_12_p40	64,82	IL-12p40	interleukin 12 p40	16160(Tax:10090)	16160(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin_12_p40 -LRB- IL-12p40 -RRB- expression by activating extracellular_signal-regulated_kinase_1 / 2 , which is further potentiated by glucocorticoids .
9822675	0	IL-13	43,48	15-lipoxygenase	13,28	IL-13	15-lipoxygenase	3596	246	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes .
16488622	0	IL-13	36,41	4-1BB	17,22	IL-13	4-1BB	3596	3604	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Cross-linking of 4-1BB up-regulates IL-13 expression in CD8 -LRB- + -RRB- T lymphocytes .
23881867	0	IL-13	48,53	C/EBP-a	25,32	IL-13	C/EBP-a	3596	1050	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Reciprocal modulation of C/EBP-a and C/EBP-b by IL-13 in activated microglia prevents neuronal_death .
7545713	0	IL-13	0,5	CD14	21,25	IL-13	CD14	3596	929	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	IL-13 down-regulates CD14 expression and TNF-alpha secretion in normal human monocytes .
12193714	0	IL-13	51,56	CD30	16,20	IL-13	CD30	3596	943	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 _ mitogen-activated_protein_kinase-dependent mechanism .
17458857	0	IL-13	0,5	CD36	28,32	IL-13	CD36	3596	948	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IL-13 induces expression of CD36 in human monocytes through PPARgamma activation .
11809914	0	IL-13	17,22	CD4	48,51	IL-13	CD4	3596	920	Gene	Gene	production|compound|START_ENTITY production|nmod|T T|compound|END_ENTITY	Dysregulation of IL-13 production by cord blood CD4 + T cells is associated with the subsequent development of atopic_disease in infants .
8980464	0	IL-13	8,13	CD4	17,20	IL-13	CD4	3596	920	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|production production|compound|END_ENTITY	Role of IL-13 in CD4 T cell-dependent IgE production in atopy .
16488622	0	IL-13	36,41	CD8	56,59	IL-13	CD8	3596	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Cross-linking of 4-1BB up-regulates IL-13 expression in CD8 -LRB- + -RRB- T lymphocytes .
19582753	0	IL-13	48,53	CD8	80,83	IL-13	CD8	3596	925	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|CTL CTL|compound|END_ENTITY	Immunisation route-dependent expression of IL-4 / IL-13 can modulate HIV-specific CD8 -LRB- + -RRB- CTL avidity .
25493691	0	IL-13	67,72	CD8	34,37	IL-13	CD8	3596	925	Gene	Gene	START_ENTITY|dep|Regulated Regulated|nsubjpass|Expression Expression|nmod|Cells Cells|compound|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
7495748	0	IL-13	27,32	CD8	62,65	IL-13	CD8	3596	925	Gene	Gene	production|compound|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Differential regulation of IL-13 and IL-4 production by human CD8 + and CD4 + Th0 , Th1 and Th2 T cell clones and EBV-transformed B cells .
17392576	0	IL-13	209,214	CXCL8	188,193	IL-13	CXCL8	3596	3576	Gene	Gene	IL-8|appos|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
20652946	0	IL-13	0,5	GPIIb	18,23	IL-13	GPIIb	3596	3674	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	IL-13 upregulates GPIIb expression in megakaryocytic cell lines via STAT6 .
18279945	0	IL-13	34,39	HuR	84,87	IL-13	HuR	3596	1994	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Posttranscriptional regulation of IL-13 in T cells : role of the RNA-binding protein HuR .
17023392	0	IL-13	65,70	IL-13R_alpha2	26,39	IL-13	IL-13R alpha2	3596	3598	Gene	Gene	activity|compound|START_ENTITY essential|nmod|activity essential|nsubj|glycosylation glycosylation|nmod|END_ENTITY	N-linked glycosylation of IL-13R_alpha2 is essential for optimal IL-13 inhibitory activity .
18938165	0	IL-13	0,5	IL-13R_alpha2	20,33	IL-13	IL-13R alpha2	16163(Tax:10090)	16165(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	IL-13 signaling via IL-13R_alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS_colitis .
21622864	0	IL-13	0,5	IL-13Ra2	89,97	IL-13	IL-13Ra2	3596	3598	Gene	Gene	antibodies|compound|START_ENTITY influence|nsubj|antibodies influence|advcl|modulating modulating|dobj|activity activity|nmod|END_ENTITY	IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Ra2 .
21622864	0	IL-13	27,32	IL-13Ra2	89,97	IL-13	IL-13Ra2	3596	3598	Gene	Gene	clearance|compound|START_ENTITY influence|dobj|clearance influence|advcl|modulating modulating|dobj|activity activity|nmod|END_ENTITY	IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Ra2 .
24143891	0	IL-13	0,5	IL-13Ra2	20,28	IL-13	IL-13Ra2	16163(Tax:10090)	16165(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	IL-13 signaling via IL-13Ra2 triggers TGF-b1-dependent allograft fibrosis .
24954262	0	IL-13	29,34	IL-13Ra2	51,59	IL-13	IL-13Ra2	3596	3598	Gene	Gene	bioactivity|compound|START_ENTITY bioactivity|nmod|induction induction|compound|END_ENTITY	TNF-a/IL -17 synergy inhibits IL-13 bioactivity via IL-13Ra2 induction .
17392576	0	IL-13	209,214	IL-2	164,168	IL-13	IL-2	3596	3558	Gene	Gene	IL-8|appos|START_ENTITY IL-8|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17881510	0	IL-13	14,19	IL-33	0,5	IL-13	IL-33	16163(Tax:10090)	77125(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals .
23248269	0	IL-13	22,27	IL-33	0,5	IL-13	IL-33	3596	90865	Gene	Gene	production|compound|START_ENTITY drives|dobj|production drives|nsubj|END_ENTITY	IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms .
23521712	0	IL-13	111,116	IL-33	7,12	IL-13	IL-33	3596	90865	Gene	Gene	up-regulation|nmod|START_ENTITY associated|nmod|up-regulation associated|nsubjpass|response response|compound|END_ENTITY	A late IL-33 response after exposure to Schistosoma_haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils .
23683462	0	IL-13	27,32	IL-33	72,77	IL-13	IL-33	16163(Tax:10090)	77125(Tax:10090)	Gene	Gene	production|compound|START_ENTITY requires|nsubj|production requires|xcomp|END_ENTITY	Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3 .
24822215	0	IL-13	64,69	IL-33	0,5	IL-13	IL-33	3596	90865	Gene	Gene	production|nmod|START_ENTITY enhanced|dobj|production enhanced|nsubj|END_ENTITY	IL-33 enhanced the proliferation and constitutive production of IL-13 and IL-5 by fibrocytes .
26044350	0	IL-13	71,76	IL-33	81,86	IL-13	IL-33	16163(Tax:10090)	77125(Tax:10090)	Gene	Gene	START_ENTITY|nmod|ST2 ST2|compound|END_ENTITY	Natural helper cells contribute to pulmonary_eosinophilia by producing IL-13 via IL-33 / ST2 pathway in a murine model of respiratory_syncytial_virus_infection .
26555705	0	IL-13	41,46	IL-33	4,9	IL-13	IL-33	16163(Tax:10090)	77125(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|receptor receptor|compound|END_ENTITY	The IL-33 receptor -LRB- ST2 -RRB- regulates early IL-13 production in fungus-induced allergic_airway_inflammation .
26833119	0	IL-13	20,25	IL-33	14,19	IL-13	IL-33	3596	90865	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the IL-33 / IL-13 Axis for Respiratory Viral_Infections .
10049749	0	IL-13	58,63	IL-4	53,57	IL-13	IL-4	3596	3565	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Intergenic transcription occurs throughout the human IL-4 / IL-13 gene cluster .
10335482	0	IL-13	0,5	IL-4	25,29	IL-13	IL-4	3596	3565	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	IL-13 can substitute for IL-4 in the generation of dendritic cells for the induction of cytotoxic T lymphocytes and gene therapy .
10679097	0	IL-13	111,116	IL-4	95,99	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	agent|nsubj|START_ENTITY defines|parataxis|agent defines|dobj|roles roles|nmod|END_ENTITY	Schistosome infection of transgenic_mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13 : IL-13 is a profibrotic agent .
10940898	0	IL-13	61,66	IL-4	39,43	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|expulsion expulsion|nmod|mice mice|compound|END_ENTITY	Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent .
11058569	0	IL-13	66,71	IL-4	20,24	IL-13	IL-4	3596	3565	Gene	Gene	chain|compound|START_ENTITY dependent|nmod|chain signals|xcomp|dependent signals|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1 : redundancy of requirement of tyrosine residue for STAT3 activation .
11120785	0	IL-13	47,52	IL-4	42,46	IL-13	IL-4	3596	3565	Gene	Gene	region|compound|START_ENTITY edge|dep|region edge|dep|remodeling remodeling|nmod|END_ENTITY	Cutting edge : chromatin remodeling at the IL-4 / IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster .
11160216	0	IL-13	50,55	IL-4	45,49	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY Reconstitution|dep|receptor Reconstitution|nmod|END_ENTITY	Reconstitution of a functional human type II IL-4 / IL-13 receptor in mouse B cells : demonstration of species specificity .
11179348	0	IL-13	173,178	IL-4	167,171	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY colonization|dep|receptor colonization|appos|END_ENTITY	Adoptive transfer of CD4 + T cells specific for subunit A of Helicobacter_pylori urease reduces H. _ pylori stomach colonization in mice in the absence of interleukin-4 -LRB- IL-4 -RRB- / IL-13 receptor signaling .
11591117	0	IL-13	173,178	IL-4	23,27	IL-13	IL-4	3596	3565	Gene	Gene	receptors|compound|START_ENTITY loss|nmod|receptors effect|dep|loss effect|nmod|END_ENTITY	Differential effect of IL-4 and IL-13 on CD44 expression in the Burkitt 's _ lymphoma B cell line BL30/B95 -8 and in Epstein-Barr_virus _ -LRB- EBV -RRB- transformed human B cells : loss of IL-13 receptors on Burkitt 's _ lymphoma B cells .
11709700	0	IL-13	17,22	IL-4	48,52	IL-13	IL-4	3596	3565	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|alpha2-chain alpha2-chain|nmod|END_ENTITY	Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes : involvement of STAT6 , ERK and p38 MAPK pathways .
11813160	0	IL-13	20,25	IL-4	100,104	IL-13	IL-4	3596	3565	Gene	Gene	+|compound|START_ENTITY Distinction|nmod|+ +|nsubj|Distinction +|nmod|END_ENTITY	Distinction between IL-13 + and IFN-gamma + natural killer cells and regulation of their pool size by IL-4 .
12421669	0	IL-13	48,53	IL-4	43,47	IL-13	IL-4	3596	3565	Gene	Gene	system|amod|START_ENTITY system|nmod|antagonists antagonists|nmod|END_ENTITY	Structure , binding , and antagonists in the IL-4 / IL-13 receptor system .
12789240	0	IL-13	23,28	IL-4	18,22	IL-13	IL-4	3596	3565	Gene	Gene	system|compound|START_ENTITY prevents|nsubj|system Inhibition|parataxis|prevents Inhibition|nmod|END_ENTITY	Inhibition of the IL-4 / IL-13 receptor system prevents allergic_sensitization without affecting established allergy in a mouse model for allergic_asthma .
14618299	0	IL-13	70,75	IL-4	44,48	IL-13	IL-4	116553(Tax:10116)	287287(Tax:10116)	Gene	Gene	interleukin-4|appos|START_ENTITY interleukin-4|appos|END_ENTITY	Glucocorticoid inhibition of interleukin-4 -LRB- IL-4 -RRB- and interleukin-13 -LRB- IL-13 -RRB- induced up-regulation of arginase in rat airway fibroblasts .
14983029	0	IL-13	55,60	IL-4	50,54	IL-13	IL-4	3596	3565	Gene	Gene	gene|compound|START_ENTITY cluster|nsubj|gene Analysis|parataxis|cluster Analysis|nmod|END_ENTITY	Analysis of intergenic transcription in the human IL-4 / IL-13 gene cluster .
15322207	0	IL-13	103,108	IL-4	98,102	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung_fibrosis : role of IL-4 / IL-13 and mediation via STAT-6 .
16141241	0	IL-13	28,33	IL-4	0,4	IL-13	IL-4	3596	3565	Gene	Gene	effective|nmod|START_ENTITY effective|nsubj|END_ENTITY	IL-4 is more effective than IL-13 for in vitro differentiation of dendritic cells from peripheral blood mononuclear cells .
16702603	0	IL-13	38,43	IL-4	33,37	IL-13	IL-4	3596	3565	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Type 2 immunity is controlled by IL-4 / IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system .
16849611	0	IL-13	146,151	IL-4	141,145	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|appos|independent independent|nmod|END_ENTITY	The dermal microenvironment induces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes , independent of IL-4 / IL-13 signaling .
17070934	0	IL-13	0,5	IL-4	15,19	IL-13	IL-4	396721(Tax:9823)	397225(Tax:9823)	Gene	Gene	replaces|nsubj|START_ENTITY replaces|dobj|END_ENTITY	IL-13 replaces IL-4 in development of monocyte derived dendritic cells -LRB- MoDC -RRB- of swine .
17077644	0	IL-13	19,24	IL-4	14,18	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	enhance|nsubj|START_ENTITY Inhibition|parataxis|enhance Inhibition|nmod|END_ENTITY	Inhibition of IL-4 / IL-13 does not enhance the efficacy of allergen immunotherapy in murine allergic airway inflammation .
17392576	0	IL-13	209,214	IL-4	170,174	IL-13	IL-4	3596	3565	Gene	Gene	IL-8|appos|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
18996576	0	IL-13	15,20	IL-4	10,14	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Targeting IL-4 / IL-13 signaling to alleviate oral allergen-induced diarrhea .
19582753	0	IL-13	48,53	IL-4	43,47	IL-13	IL-4	3596	3565	Gene	Gene	modulate|nsubj|START_ENTITY expression|parataxis|modulate expression|nmod|END_ENTITY	Immunisation route-dependent expression of IL-4 / IL-13 can modulate HIV-specific CD8 -LRB- + -RRB- CTL avidity .
19796211	0	IL-13	47,52	IL-4	42,46	IL-13	IL-4	3596	3565	Gene	Gene	antagonist|compound|START_ENTITY effects|dep|antagonist effects|nmod|END_ENTITY	Inhaled vs subcutaneous effects of a dual IL-4 / IL-13 antagonist in a monkey model of asthma .
20500673	0	IL-13	23,28	IL-4	18,22	IL-13	IL-4	116553(Tax:10116)	287287(Tax:10116)	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Direct effects of IL-4 / IL-13 and the nematode_Nippostrongylus_brasiliensis on intestinal epithelial cells in vitro .
20729386	0	IL-13	19,24	IL-4	14,18	IL-13	IL-4	3596	3565	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|Expression Expression|nmod|END_ENTITY	Expression of IL-4 / IL-13 receptors in differentiating human airway epithelial cells .
21157648	0	IL-13	24,29	IL-4	19,23	IL-13	IL-4	3596	3565	Gene	Gene	antagonist|compound|START_ENTITY Pitrakinra|dep|antagonist Pitrakinra|appos|END_ENTITY	Pitrakinra , a dual IL-4 / IL-13 antagonist for the potential treatment of asthma and eczema .
21814192	0	IL-13	17,22	IL-4	12,16	IL-13	IL-4	3596	3565	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	STAT6 links IL-4 / IL-13 stimulation with pendrin expression in asthma and chronic_obstructive_pulmonary_disease .
22019418	0	IL-13	37,42	IL-4	32,36	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	has|nsubj|START_ENTITY END_ENTITY|appos|has	Lack of signaling by IL-4 or by IL-4 / IL-13 has more attenuating effects on Leishmania amazonensis dorsal skin -- than on footpad-infected mice .
23449738	0	IL-13	8,13	IL-4	3,7	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	antagonist|compound|START_ENTITY reduces|nsubj|antagonist END_ENTITY|parataxis|reduces	An IL-4 / IL-13 dual antagonist reduces lung_inflammation , airway hyperresponsiveness , and IgE production in mice .
23553437	0	IL-13	19,24	IL-4	14,18	IL-13	IL-4	3596	3565	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the IL-4 / IL-13 signaling pathway sensitizes Hodgkin_lymphoma cells to chemotherapeutic drugs .
23582327	5	IL-13	613,618	IL-4	608,612	IL-13	IL-4	3596	3565	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	In FAPs , IL-4 / IL-13 signaling serves as a key switch to control their fate and functions .
23880771	0	IL-13	111,116	IL-4	85,89	IL-13	IL-4	3596	3565	Gene	Gene	interleukin-4|appos|START_ENTITY interleukin-4|appos|END_ENTITY	Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 -LRB- IL-4 -RRB- and interleukin-13 -LRB- IL-13 -RRB- cytokines .
25172500	0	IL-13	20,25	IL-4	15,19	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY END_ENTITY|parataxis|protects	T cell-derived IL-4 / IL-13 protects mice against fatal Schistosoma_mansoni_infection independently of basophils .
25472582	0	IL-13	22,27	IL-4	17,21	IL-13	IL-4	3596	3565	Gene	Gene	genes|compound|START_ENTITY Polymorphisms|dep|genes Polymorphisms|nmod|END_ENTITY	Polymorphisms in IL-4 / IL-13 pathway genes and glioma risk : an updated meta-analysis .
25493691	0	IL-13	67,72	IL-4	62,66	IL-13	IL-4	3596	3565	Gene	Gene	START_ENTITY|dep|Regulated Regulated|nmod|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
26255210	0	IL-13	30,35	IL-4	25,29	IL-13	IL-4	3596	3565	Gene	Gene	START_ENTITY|dep|targeting targeting|dobj|END_ENTITY	Strategies targeting the IL-4 / IL-13 axes in disease .
26781462	0	IL-13	42,47	IL-4	37,41	IL-13	IL-4	3596	3565	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|changes changes|nmod|expression expression|nmod|END_ENTITY	Analysis of changes in expression of IL-4 / IL-13 / STAT6 pathway and correlation with the selected clinical parameters in patients with atopic_asthma .
8605347	0	IL-13	16,21	IL-4	150,154	IL-13	IL-4	3596	3565	Gene	Gene	Interleukin-13|appos|START_ENTITY induces|nsubj|Interleukin-13 induces|dobj|expression expression|dep|inhibition inhibition|nmod|protein protein|compound|END_ENTITY	Interleukin-13 -LRB- IL-13 -RRB- induces IL-1_receptor_antagonist gene expression and protein synthesis in peripheral blood mononuclear cells : inhibition by an IL-4 mutant protein .
8609418	0	IL-13	0,5	IL-4	124,128	IL-13	IL-4	3596	3565	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|lines lines|dep|similarities similarities|nmod|signaling signaling|compound|END_ENTITY	IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon_carcinoma cell lines : similarities between IL-4 and IL-13 signaling .
9013879	0	IL-13	101,106	IL-4	96,100	IL-13	IL-4	3596	3565	Gene	Gene	receptor|compound|START_ENTITY complex|dep|receptor END_ENTITY|dep|complex	Cloning of the human IL-13R_alpha1 chain and reconstitution with the IL4R_alpha of a functional IL-4 / IL-13 receptor complex .
9099934	0	IL-13	31,36	IL-4	98,102	IL-13	IL-4	3596	3565	Gene	Gene	properties|nmod|START_ENTITY properties|dep|comparison comparison|nmod|END_ENTITY	Immunoregulatory properties of IL-13 in patients with inflammatory_bowel_disease ; comparison with IL-4 and IL-10 .
9224205	0	IL-13	0,5	IL-4	78,82	IL-13	IL-4	3596	3565	Gene	Gene	mRNA|compound|START_ENTITY mRNA|dep|comparison comparison|nmod|expression expression|compound|END_ENTITY	IL-13 mRNA and immunoreactivity in allergen-induced rhinitis : comparison with IL-4 expression and modulation by topical glucocorticoid therapy .
9647227	0	IL-13	82,87	IL-4	146,150	IL-13	IL-4	3596	3565	Gene	Gene	pathway|nmod|START_ENTITY regulation|nmod|pathway regulation|dep|study study|nmod|END_ENTITY	Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells : a comparative study with IL-4 .
9856950	0	IL-13	16,21	IL-4	39,43	IL-13	IL-4	16163(Tax:10090)	16189(Tax:10090)	Gene	Gene	independently|compound|START_ENTITY independently|nmod|END_ENTITY	Requirement for IL-13 independently of IL-4 in experimental asthma .
21210100	0	IL-13	77,82	IL-4Ra	94,100	IL-13	IL-4Ra	3596	3566	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Two copies of the genes encoding the subunits of putative interleukin -LRB- IL -RRB- -4 / IL-13 receptors , IL-4Ra , IL-13Ra1 and IL-13Ra2 , have been identified in rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- and have complex patterns of expression and modulation .
24979482	0	IL-13	4,9	IL-4Ra	10,16	IL-13	IL-4Ra	3596	3566	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|axis axis|compound|END_ENTITY	The IL-13 / IL-4Ra axis is involved in tuberculosis-associated pathology .
11590387	0	IL-13	0,5	IL-5	57,61	IL-13	IL-5	16163(Tax:10090)	16191(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|lung lung|nmod|mechanism mechanism|amod|END_ENTITY	IL-13 induces eosinophil recruitment into the lung by an IL-5 - and eotaxin-dependent mechanism .
14598258	0	IL-13	14,19	IL-5	59,63	IL-13	IL-5	16163(Tax:10090)	16191(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Intratracheal IL-13 induces eosinophilic_esophagitis by an IL-5 , eotaxin-1 , and STAT6-dependent mechanism .
15563687	0	IL-13	0,5	IL-5	72,76	IL-13	IL-5	16163(Tax:10090)	16191(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|hyperresponsiveness hyperresponsiveness|nmod|END_ENTITY	IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway_smooth_muscle .
16495517	0	IL-13	78,83	IL-5	15,19	IL-13	IL-5	16163(Tax:10090)	16191(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulating|dobj|activity augments|advcl|regulating augments|nsubj|Interleukin-5 Interleukin-5|appos|END_ENTITY	Interleukin-5 -LRB- IL-5 -RRB- augments the progression of liver_fibrosis by regulating IL-13 activity .
17392576	0	IL-13	209,214	IL-5	176,180	IL-13	IL-5	3596	3567	Gene	Gene	IL-8|appos|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17392576	0	IL-13	209,214	IL-6	182,186	IL-13	IL-6	3596	3569	Gene	Gene	IL-8|appos|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
20189822	0	IL-13	13,18	IL-6	115,119	IL-13	IL-6	16163(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|compound|START_ENTITY Induction|nmod|production Induction|nmod|protease_activated_receptors protease_activated_receptors|nmod|cells cells|nmod|END_ENTITY	Induction of IL-13 production and upregulation of gene expression of protease_activated_receptors in P815 cells by IL-6 .
26462420	0	IL-13	21,26	LRRC31	0,6	IL-13	LRRC31	3596	79782	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium .
21239604	0	IL-13	53,58	MUC18	17,22	IL-13	MUC18	3596	4162	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Up-regulation of MUC18 in airway epithelial cells by IL-13 : implications in bacterial adherence .
12403127	0	IL-13	0,5	MUC5AC	17,23	IL-13	MUC5AC	3596	4586	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	IL-13 suppresses MUC5AC gene expression and mucin secretion in nasal epithelial cells .
26160172	0	IL-13	16,21	Mac-1	0,5	IL-13	Mac-1	16163(Tax:10090)	16409(Tax:10090)	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Ra1 .
19607912	0	IL-13	50,55	NFATc1	14,20	IL-13	NFATc1	3596	4772	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	JNK-dependent NFATc1 pathway positively regulates IL-13 gene expression induced by -LRB- - -RRB- - epigallocatechin-3-gallate in human basophilic KU812 cells .
11544458	0	IL-13	41,46	Nerve_growth_factor	0,19	IL-13	Nerve growth factor	3596	4803	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Nerve_growth_factor or IL-3 induces more IL-13 production from basophils of allergic subjects than from basophils of nonallergic subjects .
17458857	0	IL-13	0,5	PPARgamma	60,69	IL-13	PPARgamma	3596	5468	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	IL-13 induces expression of CD36 in human monocytes through PPARgamma activation .
10514388	0	IL-13	0,5	STAT6	16,21	IL-13	STAT6	16163(Tax:10090)	20852(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	IL-13 activates STAT6 and inhibits liver_injury induced by ischemia/reperfusion .
11709700	0	IL-13	17,22	STAT6	102,107	IL-13	STAT6	3596	6778	Gene	Gene	receptor|compound|START_ENTITY Induction|nmod|receptor Induction|dep|involvement involvement|nmod|pathways pathways|compound|ERK ERK|compound|END_ENTITY	Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes : involvement of STAT6 , ERK and p38 MAPK pathways .
12776189	0	IL-13	31,36	STAT6	112,117	IL-13	STAT6	3596	6778	Gene	Gene	promoter|compound|START_ENTITY characterization|nmod|promoter characterization|dep|role role|nmod|END_ENTITY	Functional characterization of IL-13 receptor alpha2 gene promoter : a critical role of the transcription factor STAT6 for regulated expression .
12935900	0	IL-13	83,88	STAT6	51,56	IL-13	STAT6	3596	6778	Gene	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation .
20652946	0	IL-13	0,5	STAT6	68,73	IL-13	STAT6	3596	6778	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|lines lines|nmod|END_ENTITY	IL-13 upregulates GPIIb expression in megakaryocytic cell lines via STAT6 .
21814192	0	IL-13	17,22	STAT6	0,5	IL-13	STAT6	3596	6778	Gene	Gene	stimulation|compound|START_ENTITY links|dobj|stimulation links|nsubj|END_ENTITY	STAT6 links IL-4 / IL-13 stimulation with pendrin expression in asthma and chronic_obstructive_pulmonary_disease .
21826890	0	IL-13	85,90	STAT6	91,96	IL-13	STAT6	3596	6778	Gene	Gene	fibroblasts|nmod|START_ENTITY production|nmod|fibroblasts effect|nmod|production effect|parataxis|signaling signaling|nsubj|END_ENTITY	-LSB- Inhibitory effect of paeoniflorin on the collagen production by fibroblasts through IL-13 / STAT6 signaling pathway -RSB- .
26423151	0	IL-13	96,101	STAT6	116,121	IL-13	STAT6	16163(Tax:10090)	20852(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic_Steatosis in Mice Dependent upon IL-13 Activation of STAT6 .
26781462	0	IL-13	42,47	STAT6	48,53	IL-13	STAT6	3596	6778	Gene	Gene	Analysis|dep|START_ENTITY END_ENTITY|nsubj|Analysis	Analysis of changes in expression of IL-4 / IL-13 / STAT6 pathway and correlation with the selected clinical parameters in patients with atopic_asthma .
9200476	0	IL-13	0,5	TNF	15,18	IL-13	TNF	16163(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	IL-13 inhibits TNF production but potentiates that of IL-6 in vivo and ex vivo in mice .
22039304	0	IL-13	40,45	c-Myb	0,5	IL-13	c-Myb	3596	4602	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed_lineage_leukemia -LRB- MLL -RRB- for histone modification of the IL-13 locus .
10521702	0	IL-13	0,5	cPLA2	40,45	IL-13	cPLA2	16163(Tax:10090)	18783(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic_acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production .
9748607	0	IL-13	0,5	cPLA2	20,25	IL-13	cPLA2	16163(Tax:10090)	18783(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|gene gene|amod|END_ENTITY	IL-13 increases the cPLA2 gene and protein expression and the mobilization of arachidonic_acid during an inflammatory process in mouse peritoneal macrophages .
21804025	0	IL-13	0,5	connective_tissue_growth_factor	14,45	IL-13	connective tissue growth factor	116553(Tax:10116)	64032(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-13 induces connective_tissue_growth_factor in rat hepatic stellate cells via TGF-b-independent Smad signaling .
10072486	0	IL-13	62,67	eotaxin	85,92	IL-13	eotaxin	16163(Tax:10090)	20292(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Effects of Th2 cytokines on chemokine expression in the lung : IL-13 potently induces eotaxin expression by airway epithelial cells .
10651852	0	IL-13	50,55	interleukin-13	34,48	IL-13	interleukin-13	3596	3596	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	A novel polymorphism in the human interleukin-13 -LRB- IL-13 -RRB- promoter .
17287216	0	IL-13	46,51	interleukin-13	30,44	IL-13	interleukin-13	3596	3596	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Lysophosphatidic_acid induces interleukin-13 -LRB- IL-13 -RRB- receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells .
21097505	0	IL-13	20,25	interleukin_13	4,18	IL-13	interleukin 13	3596	3596	Gene	Gene	pathway|appos|START_ENTITY pathway|compound|END_ENTITY	The interleukin_13 -LRB- IL-13 -RRB- pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin_13 receptor alpha1 -LRB- IL13Ralpha1 -RRB- .
16792687	0	IL-13	23,28	monocyte_chemoattractant_protein-1	41,75	IL-13	monocyte chemoattractant protein-1	3596	6347	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Interleukin -LRB- IL -RRB- -4 and IL-13 up-regulate monocyte_chemoattractant_protein-1 expression in human bronchial epithelial cells : involvement of p38_mitogen-activated_protein_kinase , extracellular_signal-regulated_kinase 1/2 and Janus_kinase-2 but not c-Jun_NH2-terminal_kinase 1/2 signalling pathways .
20107485	0	IL-13	33,38	mu-Opioid_receptor	0,18	IL-13	mu-Opioid receptor	3596	4988	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	mu-Opioid_receptor is induced by IL-13 within lymph nodes from patients with S zary syndrome .
11133503	0	IL-13	0,5	mucin	14,19	IL-13	mucin	3596	100508689	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-13 induces mucin production by stimulating epidermal_growth_factor_receptors and by activating neutrophils .
16980555	0	IL-13	0,5	mucin	95,100	IL-13	mucin	3596	100508689	Gene	Gene	have|nsubj|START_ENTITY have|dobj|roles roles|nmod|production production|compound|END_ENTITY	IL-13 and epidermal_growth_factor_receptor have critical but distinct roles in epithelial cell mucin production .
16374482	0	IL-13	41,46	tenascin-C	16,26	IL-13	tenascin-C	3596	3371	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein_kinase_C signaling pathways .
7529288	0	IL-13	0,5	vascular_cell_adhesion_molecule-1	26,59	IL-13	vascular cell adhesion molecule-1	3596	7412	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IL-13 selectively induces vascular_cell_adhesion_molecule-1 expression in human endothelial cells .
17023392	0	IL-13R_alpha2	26,39	IL-13	65,70	IL-13R alpha2	IL-13	3598	3596	Gene	Gene	glycosylation|nmod|START_ENTITY essential|nsubj|glycosylation essential|nmod|activity activity|compound|END_ENTITY	N-linked glycosylation of IL-13R_alpha2 is essential for optimal IL-13 inhibitory activity .
18938165	0	IL-13R_alpha2	20,33	IL-13	0,5	IL-13R alpha2	IL-13	16165(Tax:10090)	16163(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	IL-13 signaling via IL-13R_alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS_colitis .
23650613	0	IL-13Ra1	99,107	Th1	119,122	IL-13Ra1	Th1	16164(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Developmental expression of IL-12Rb2 on murine naive neonatal T cells counters the upregulation of IL-13Ra1 on primary Th1 cells and balances immunity in the newborn .
21622864	0	IL-13Ra2	89,97	IL-13	0,5	IL-13Ra2	IL-13	3598	3596	Gene	Gene	activity|nmod|START_ENTITY modulating|dobj|activity influence|advcl|modulating influence|nsubj|antibodies antibodies|compound|END_ENTITY	IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Ra2 .
21622864	0	IL-13Ra2	89,97	IL-13	27,32	IL-13Ra2	IL-13	3598	3596	Gene	Gene	activity|nmod|START_ENTITY modulating|dobj|activity influence|advcl|modulating influence|dobj|clearance clearance|compound|END_ENTITY	IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Ra2 .
24143891	0	IL-13Ra2	20,28	IL-13	0,5	IL-13Ra2	IL-13	16165(Tax:10090)	16163(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	IL-13 signaling via IL-13Ra2 triggers TGF-b1-dependent allograft fibrosis .
24954262	0	IL-13Ra2	51,59	IL-13	29,34	IL-13Ra2	IL-13	3598	3596	Gene	Gene	induction|compound|START_ENTITY bioactivity|nmod|induction bioactivity|compound|END_ENTITY	TNF-a/IL -17 synergy inhibits IL-13 bioactivity via IL-13Ra2 induction .
12816724	0	IL-13Ra2	83,91	interleukin_13_alpha_2_receptor	50,81	IL-13Ra2	interleukin 13 alpha 2 receptor	3598	3598	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Molecular cloning and identification of the human interleukin_13_alpha_2_receptor -LRB- IL-13Ra2 -RRB- promoter .
15805299	0	IL-13Ralpha2	84,96	Stat3	9,14	IL-13Ralpha2	Stat3	3598	6774	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Aberrant Stat3 signaling by interleukin-4 in malignant_glioma cells : involvement of IL-13Ralpha2 .
12192597	0	IL-13Ralpha2	0,12	interleukin-13	49,63	IL-13Ralpha2	interleukin-13	3598	3596	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	IL-13Ralpha2 is a glioma-restricted receptor for interleukin-13 .
21236478	0	IL-13_receptor	38,52	IL-17A	74,80	IL-13 receptor	IL-17A	3598	3605	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Human TH17 cells express a functional IL-13_receptor and IL-13 attenuates IL-17A production .
20871627	0	IL-15	64,69	4-1BB_ligand	82,94	IL-15	4-1BB ligand	3600	8744	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Immobilized MHC_class_I_chain-related_protein_A synergizes with IL-15 and soluble 4-1BB_ligand to expand NK cells with high cytotoxicity ex vivo .
24670802	0	IL-15	16,21	BAFF	0,4	IL-15	BAFF	16168(Tax:10090)	24099(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	BAFF suppresses IL-15 expression in B cells .
16078278	0	IL-15	46,51	CD16	14,18	IL-15	CD16	3600	2214	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|dep|cells	Human resting CD16 - , CD16 + and IL-2 - , IL-12 - , IL-15 - or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine , lysophosphatidylcholine and platelet-activating factor .
16078278	0	IL-15	46,51	CD16	21,25	IL-15	CD16	3600	2214	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Human resting CD16 - , CD16 + and IL-2 - , IL-12 - , IL-15 - or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine , lysophosphatidylcholine and platelet-activating factor .
18493981	0	IL-15	0,5	CD25	40,44	IL-15	CD25	3600	3559	Gene	Gene	acts|nsubj|START_ENTITY acts|advcl|expressing expressing|nsubj|inducer inducer|nmod|cells cells|amod|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
23028916	0	IL-15	0,5	CD25	100,104	IL-15	CD25	16168(Tax:10090)	16184(Tax:10090)	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|expansion expansion|nmod|cells cells|amod|vitro vitro|advcl|inhibiting inhibiting|dobj|function function|nmod|T T|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
21635686	0	IL-15	0,5	CD28	117,121	IL-15	CD28	3600	940	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|cells cells|compound|END_ENTITY	IL-15 preferentially enhances functional properties and antigen-specific responses of CD4 + CD28 -LRB- null -RRB- compared to CD4 + CD28 + T cells .
23711708	0	IL-15	41,46	CD28	109,113	IL-15	CD28	3600	940	Gene	Gene	cells|nmod|START_ENTITY induce|nsubj|cells induce|dobj|responses responses|compound|END_ENTITY	Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8 + CD28 + T lymphocyte responses .
16129046	0	IL-15	11,16	CD34	77,81	IL-15	CD34	3600	947	Gene	Gene	START_ENTITY|nmod|proliferation proliferation|nmod|END_ENTITY	-LSB- Effect of IL-15 on the proliferation , differentiation and anti-apoptosis of CD34 + cells in patients with MDS -RSB- .
11550091	0	IL-15	114,119	CD4	21,24	IL-15	CD4	3600	920	Gene	Gene	interleukin-15|appos|START_ENTITY prevented|nmod|interleukin-15 apoptosis|acl:relcl|prevented prone|nmod|apoptosis T|ccomp|prone T|nsubj|subset subset|nmod|memory memory|compound|END_ENTITY	The CD7 -LRB- - -RRB- subset of CD4 -LRB- + -RRB- memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 -LRB- IL-15 -RRB- .
14662842	0	IL-15	0,5	CD4	96,99	IL-15	CD4	3600	920	Gene	Gene	antigen|amod|START_ENTITY expand|nsubj|antigen expand|dobj|cells cells|compound|END_ENTITY	IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4 + T cells that require antigen-specific activation for suppression .
15308379	0	IL-15	0,5	CD4	82,85	IL-15	CD4	699616(Tax:9544)	713807(Tax:9544)	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|IL-2 IL-2|nmod|generation generation|nmod|END_ENTITY	IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus_macaques .
15972637	0	IL-15	33,38	CD4	139,142	IL-15	CD4	3600	920	Gene	Gene	Coimmunization|nmod|START_ENTITY plasmid|nsubj|Coimmunization plasmid|nmod|function function|nmod|cells cells|ccomp|independent independent|nmod|help help|compound|END_ENTITY	Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help .
16614074	0	IL-15	8,13	CD4	51,54	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	results|compound|START_ENTITY Lack|nmod|results Lack|nmod|priming priming|nmod|response response|compound|END_ENTITY	Lack of IL-15 results in the suboptimal priming of CD4 + T cell response against an intracellular parasite .
16691294	0	IL-15	0,5	CD4	14,17	IL-15	CD4	3600	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-15 induces CD4 effector memory_T cell production and tissue emigration in nonhuman primates .
17420265	0	IL-15	34,39	CD4	10,13	IL-15	CD4	3600	920	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|cells cells|compound|END_ENTITY	Antiviral CD4 + memory T cells are IL-15 dependent .
17823984	0	IL-15	0,5	CD4	62,65	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	exacerbates|nsubj|START_ENTITY exacerbates|nmod|response response|compound|END_ENTITY	IL-15 exacerbates collagen-induced_arthritis with an enhanced CD4 + T cell response to produce IL-17 .
18362335	0	IL-15	0,5	CD4	23,26	IL-15	CD4	3600	920	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|+ +|compound|END_ENTITY	IL-15 as a mediator of CD4 + help for CD8 + T cell longevity and avoidance of TRAIL-mediated apoptosis .
18493981	0	IL-15	0,5	CD4	34,37	IL-15	CD4	3600	920	Gene	Gene	acts|nsubj|START_ENTITY acts|advcl|expressing expressing|nsubj|inducer inducer|nmod|cells cells|amod|END_ENTITY	IL-15 acts as a potent inducer of CD4 -LRB- + -RRB- CD25 -LRB- hi -RRB- cells expressing FOXP3 .
19155491	0	IL-15	10,15	CD4	78,81	IL-15	CD4	3600	920	Gene	Gene	production|compound|START_ENTITY associated|nsubjpass|production associated|nmod|susceptibility susceptibility|nmod|cells cells|compound|END_ENTITY	Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian_immunodeficiency_virus during acute_infection .
20007590	0	IL-15	58,63	CD4	102,105	IL-15	CD4	3600	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|equilibrium equilibrium|nmod|+ +|compound|END_ENTITY	A dual action of rheumatoid_arthritis synovial fibroblast IL-15 expression on the equilibrium between CD4 + CD25 + regulatory T cells and CD4 + CD25 - responder T cells .
21474552	0	IL-15	0,5	CD4	24,27	IL-15	CD4	3600	920	Gene	Gene	vivo|compound|START_ENTITY overcomes|nsubj|vivo overcomes|dobj|deficiency deficiency|compound|END_ENTITY	IL-15 ex vivo overcomes CD4 + T cell deficiency for the induction of human antigen-specific CD8 + T cell responses .
21635686	0	IL-15	0,5	CD4	113,116	IL-15	CD4	3600	920	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|cells cells|compound|END_ENTITY	IL-15 preferentially enhances functional properties and antigen-specific responses of CD4 + CD28 -LRB- null -RRB- compared to CD4 + CD28 + T cells .
21673554	0	IL-15	116,121	CD4	38,41	IL-15	CD4	3600	920	Gene	Gene	response|nmod|START_ENTITY proliferate|nmod|response proliferate|nsubj|cells cells|compound|END_ENTITY	Despite an impaired response to IL-7 , CD4 + EM T cells from HIV-positive patients proliferate normally in response to IL-15 and its superagonist , RLI .
21723324	0	IL-15	0,5	CD4	50,53	IL-15	CD4	3600	920	Gene	Gene	cells|amod|START_ENTITY induce|nsubj|cells induce|dobj|proliferation proliferation|nmod|CD25 CD25|compound|END_ENTITY	IL-15 and dendritic cells induce proliferation of CD4 + CD25 + regulatory T cells from peripheral blood .
21822803	0	IL-15	109,114	CD4	71,74	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY T|nmod|expression T|nsubj|expansion expansion|nmod|END_ENTITY	Selective expansion and enhanced anti-tumor effect of antigen-specific CD4 -LRB- + -RRB- T cells by retrovirus-mediated IL-15 expression .
22993203	0	IL-15	12,17	CD4	75,78	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|activating activating|nmod|T T|compound|END_ENTITY	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
22993612	0	IL-15	18,23	CD4	54,57	IL-15	CD4	3600	920	Gene	Gene	Concentrations|nmod|START_ENTITY Concentrations|nmod|END_ENTITY	Concentrations of IL-15 , IL-18 , IFN-y and activity of CD4 -LRB- + -RRB- , CD8 -LRB- + -RRB- and NK cells at admission in children with viral_bronchiolitis .
23028916	0	IL-15	0,5	CD4	110,113	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|expansion expansion|nmod|cells cells|amod|vitro vitro|advcl|inhibiting inhibiting|dobj|function function|nmod|T T|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
23028916	0	IL-15	0,5	CD4	27,30	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|expansion expansion|compound|END_ENTITY	IL-15 augments TCR-induced CD4 + T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4 + T cells .
24500400	0	IL-15	0,5	CD4	41,44	IL-15	CD4	3600	920	Gene	Gene	prolongs|nsubj|START_ENTITY prolongs|xcomp|binding binding|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24658435	0	IL-15	0,5	CD4	50,53	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	trans-presentation|compound|START_ENTITY regulates|nsubj|trans-presentation regulates|ccomp|lymphocytes lymphocytes|nsubj|homeostasis homeostasis|nmod|T T|compound|END_ENTITY	IL-15 trans-presentation regulates homeostasis of CD4 -LRB- + -RRB- T lymphocytes .
24706798	0	IL-15	0,5	CD4	81,84	IL-15	CD4	16168(Tax:10090)	12504(Tax:10090)	Gene	Gene	adjuvanted|amod|START_ENTITY vaccine|amod|adjuvanted requires|nsubj|vaccine requires|dobj|cells cells|nummod|END_ENTITY	IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4 + T cells for heterosubtypic protection .
24790790	0	IL-15	71,76	CD4	10,13	IL-15	CD4	3600	920	Gene	Gene	response|compound|START_ENTITY T|nmod|response T|nsubj|END_ENTITY	Sustained CD4 -LRB- + -RRB- T cell-driven lymphopenia without a compensatory IL-7 / IL-15 response among high-grade glioma patients treated with radiation and temozolomide .
25617471	0	IL-15	0,5	CD4	45,48	IL-15	CD4	3600	920	Gene	Gene	Amplifies|compound|START_ENTITY Amplifies|dep|Properties Properties|nmod|CD28 CD28|compound|END_ENTITY	IL-15 Amplifies the Pathogenic Properties of CD4 + CD28 - T Cells in Multiple_Sclerosis .
26034206	0	IL-15	85,90	CD4	0,3	IL-15	CD4	3600	920	Gene	Gene	lymphocytes|nmod|START_ENTITY resemble|ccomp|lymphocytes resemble|nsubj|lymphocytes lymphocytes|compound|END_ENTITY	CD4 + CD28null T lymphocytes resemble CD8 + CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients .
9725205	0	IL-15	52,57	CD4	76,79	IL-15	CD4	3600	920	Gene	Gene	activities|nmod|START_ENTITY enhance|nsubj|activities enhance|dobj|responsiveness responsiveness|compound|END_ENTITY	Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4 + T cell responsiveness to antigen .
10820241	0	IL-15	66,71	CD8	124,127	IL-15	CD8	3600	925	Gene	Gene	signals|compound|START_ENTITY allows|nsubj|signals allows|dobj|proliferation proliferation|nmod|CD44high CD44high|compound|END_ENTITY	Constitutive expression of a chimeric receptor that delivers IL-2 / IL-15 signals allows antigen-independent proliferation of CD8 + CD44high but not other T cells .
11358712	0	IL-15	59,64	CD8	25,28	IL-15	CD8	3600	925	Gene	Gene	expression|amod|START_ENTITY T-cell|dobj|expression T-cell|nsubj|analysis analysis|nmod|END_ENTITY	Longitudinal analysis of CD8 -LRB- + -RRB- T-cell phenotype and IL-7 , IL-15 and IL-16 mRNA expression in different tissues during primary simian_immunodeficiency_virus_infection .
12472672	0	IL-15	0,5	CD8	70,73	IL-15	CD8	3600	925	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cultures cultures|compound|END_ENTITY	IL-15 induces unspecific effector functions in human peptide-specific CD8 + T-cell cultures .
12805064	0	IL-15	0,5	CD8	79,82	IL-15	CD8	3600	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	IL-15 induces antigen-independent expansion and differentiation of human naive CD8 + T cells in vitro .
14684414	0	IL-15	90,95	CD8	35,38	IL-15	CD8	3600	925	Gene	Gene	role|nmod|START_ENTITY responses|dep|role responses|nummod|+ +|compound|END_ENTITY	Mature dendritic cells can enhance CD8 + cell noncytotoxic anti-HIV responses : the role of IL-15 .
14762166	0	IL-15	0,5	CD8	64,67	IL-15	CD8	3600	925	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|cells cells|compound|END_ENTITY	IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 + T cells .
15972637	0	IL-15	33,38	CD8	93,96	IL-15	CD8	3600	925	Gene	Gene	Coimmunization|nmod|START_ENTITY plasmid|nsubj|Coimmunization plasmid|nmod|function function|nmod|cells cells|compound|END_ENTITY	Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help .
16040381	0	IL-15	0,5	CD8	17,20	IL-15	CD8	3600	925	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	IL-15 : targeting CD8 + T cells for immunotherapy .
16937447	0	IL-15	20,25	CD8	60,63	IL-15	CD8	3600	925	Gene	Gene	plasmid|compound|START_ENTITY Coimmunization|nmod|plasmid enhances|nsubj|Coimmunization enhances|dobj|longevity longevity|nmod|cells cells|compound|END_ENTITY	Coimmunization with IL-15 plasmid enhances the longevity of CD8 T cells induced by DNA encoding hepatitis_B virus core antigen .
17353346	0	IL-15	129,134	CD8	68,71	IL-15	CD8	3600	925	Gene	Gene	gene|compound|START_ENTITY transduction|nmod|gene clone|nmod|transduction clone|nsubj|growth growth|nmod|T-cell T-cell|compound|END_ENTITY	Cytokine-independent growth and clonal expansion of a primary human CD8 + T-cell clone following retroviral transduction with the IL-15 gene .
17404259	0	IL-15	111,116	CD8	80,83	IL-15	CD8	3600	925	Gene	Gene	subsets|nmod|START_ENTITY T|dobj|subsets T|nsubj|pathway pathway|nmod|secretion secretion|nmod|memory memory|compound|END_ENTITY	Profound enhancement of the IL-12 / IL-18 pathway of IFN-gamma secretion in human CD8 + memory T cell subsets via IL-15 .
17635814	0	IL-15	36,41	CD8	92,95	IL-15	CD8	3600	925	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|predominance predominance|nmod|cells cells|compound|END_ENTITY	Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8 + T cells at heart lesions of human chronic Chagas_disease_cardiomyopathy .
17880761	0	IL-15	3,8	CD8	19,22	IL-15	CD8	3600	925	Gene	Gene	dependent|amod|START_ENTITY response|amod|dependent response|compound|END_ENTITY	An IL-15 dependent CD8 T cell response to selected HIV_epitopes is related to viral control in early-treated HIV-infected subjects .
18362335	0	IL-15	0,5	CD8	37,40	IL-15	CD8	3600	925	Gene	Gene	help|nsubj|START_ENTITY help|nmod|longevity longevity|compound|END_ENTITY	IL-15 as a mediator of CD4 + help for CD8 + T cell longevity and avoidance of TRAIL-mediated apoptosis .
18812469	0	IL-15	56,61	CD8	29,32	IL-15	CD8	3600	925	Gene	Gene	transpresentation|compound|START_ENTITY homeostasis|nmod|transpresentation homeostasis|compound|END_ENTITY	Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation .
19380870	0	IL-15	0,5	CD8	84,87	IL-15	CD8	3600	925	Gene	Gene	underlies|nsubj|START_ENTITY underlies|dobj|competition competition|nmod|END_ENTITY	IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and -LCB- gamma -RCB- -LCB- delta -RCB- T cells in vivo .
20212069	0	IL-15	0,5	CD8	72,75	IL-15	CD8	3600	925	Gene	Gene	trans-presentation|compound|START_ENTITY promotes|nsubj|trans-presentation promotes|dobj|survival survival|compound|END_ENTITY	IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus_infection .
20926794	0	IL-15	34,39	CD8	43,46	IL-15	CD8	3600	925	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|functions functions|compound|END_ENTITY	Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple_sclerosis .
20926799	0	IL-15	41,46	CD8	57,60	IL-15	CD8	3600	925	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|proliferation proliferation|compound|END_ENTITY	No requirement of trans presentations of IL-15 for human CD8 T cell proliferation .
20956026	0	IL-15	0,5	CD8	14,17	IL-15	CD8	3600	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|compound|END_ENTITY	IL-15 induces CD8 + T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion .
21098221	0	IL-15	11,16	CD8	46,49	IL-15	CD8	3600	925	Gene	Gene	START_ENTITY|nmod|migration migration|nmod|T T|compound|END_ENTITY	A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza_infection .
21474552	0	IL-15	0,5	CD8	91,94	IL-15	CD8	3600	925	Gene	Gene	vivo|compound|START_ENTITY overcomes|nsubj|vivo overcomes|dobj|deficiency deficiency|nmod|induction induction|nmod|responses responses|nummod|END_ENTITY	IL-15 ex vivo overcomes CD4 + T cell deficiency for the induction of human antigen-specific CD8 + T cell responses .
21911607	0	IL-15	15,20	CD8	30,33	IL-15	CD8	3600	925	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|cell cell|compound|END_ENTITY	B cell-derived IL-15 enhances CD8 T cell cytotoxicity and is increased in multiple_sclerosis patients .
22539288	0	IL-15	0,5	CD8	53,56	IL-15	CD8	16168(Tax:10090)	925	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|compound|END_ENTITY	IL-15 inhibits IL-7Ra expression by memory-phenotype CD8 T cells in the bone marrow .
23355737	0	IL-15	43,48	CD8	58,61	IL-15	CD8	3600	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	CD8a + dendritic cell trans presentation of IL-15 to naive CD8 + T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function .
23711708	0	IL-15	41,46	CD8	104,107	IL-15	CD8	3600	925	Gene	Gene	cells|nmod|START_ENTITY induce|nsubj|cells induce|dobj|responses responses|compound|END_ENTITY	Artificial antigen-presenting cells plus IL-15 and IL-21 efficiently induce melanoma-specific cytotoxic CD8 + CD28 + T lymphocyte responses .
24842641	0	IL-15	0,5	CD8	42,45	IL-15	CD8	3600	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|proliferation proliferation|compound|END_ENTITY	IL-15 induces alloreactive CD28 -LRB- - -RRB- memory CD8 T cell proliferation and CTLA4-Ig resistant memory CD8 T cell activation .
26034206	0	IL-15	85,90	CD8	36,39	IL-15	CD8	3600	925	Gene	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 + CD28null T lymphocytes resemble CD8 + CD28null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients .
26141233	0	IL-15	0,5	CD8	56,59	IL-15	CD8	3600	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|responses responses|compound|END_ENTITY	IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast_cancer .
26857736	0	IL-15	0,5	CD8	75,78	IL-15	CD8	3600	925	Gene	Gene	boosts|nsubj|START_ENTITY boosts|ccomp|differentiated differentiated|dobj|cells cells|nummod|END_ENTITY	IL-15 boosts the function and migration of human terminally differentiated CD8 + T cells by inducing a unique gene signature .
9620680	0	IL-15	77,82	CD8	53,56	IL-15	CD8	3600	925	Gene	Gene	+|nmod|START_ENTITY +|nsubj|stimulation stimulation|nmod|END_ENTITY	Potent and selective stimulation of memory-phenotype CD8 + T cells in vivo by IL-15 .
10975865	0	IL-15	22,27	IL-15	39,44	IL-15	IL-15	16168(Tax:10090)	16168(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Selective blockade of IL-15 by soluble IL-15 receptor alpha-chain enhances cardiac allograft survival .
10975865	0	IL-15	39,44	IL-15	22,27	IL-15	IL-15	16168(Tax:10090)	16168(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Selective blockade of IL-15 by soluble IL-15 receptor alpha-chain enhances cardiac allograft survival .
16815076	0	IL-15	0,5	IL-15	6,11	IL-15	IL-15	3600	3600	Gene	Gene	biology|compound|START_ENTITY biology|compound|END_ENTITY	IL-15 / IL-15 receptor biology : a guided tour through an expanding universe .
16815076	0	IL-15	6,11	IL-15	0,5	IL-15	IL-15	3600	3600	Gene	Gene	biology|compound|START_ENTITY biology|compound|END_ENTITY	IL-15 / IL-15 receptor biology : a guided tour through an expanding universe .
10415615	0	IL-15	0,5	IL-15R_alpha	6,18	IL-15	IL-15R alpha	3600	3601	Gene	Gene	START_ENTITY|appos|intracellular intracellular|nsubj|END_ENTITY	IL-15 / IL-15R_alpha intracellular trafficking in human cells and protection from apoptosis .
15693142	0	IL-15	130,135	IL-15R_alpha	136,148	IL-15	IL-15R alpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|targets targets|nsubj|cells cells|amod|complex complex|amod|END_ENTITY	Large intestine intraepithelial lymphocytes from Apc + / + and Apc + / Min mice and their modulation by indigestible carbohydrates : the IL-15 / IL-15R_alpha complex and CD4 + CD25 + T cells are the main targets .
16284400	0	IL-15	96,101	IL-15R_alpha	39,51	IL-15	IL-15R alpha	3600	3601	Gene	Gene	action|compound|START_ENTITY agonist|nmod|action END_ENTITY|nmod|agonist	Soluble interleukin-15_receptor_alpha -LRB- IL-15R_alpha -RRB- - sushi as a selective and potent agonist of IL-15 action through IL-15R_beta / gamma .
16284400	1	IL-15	149,154	IL-15R_alpha	157,169	IL-15	IL-15R alpha	3600	3601	Gene	Gene	x|nsubj|START_ENTITY x|dobj|proteins proteins|compound|END_ENTITY	Hyperagonist IL-15 x IL-15R_alpha fusion proteins .
19120059	0	IL-15	10,15	IL-15R_alpha	36,48	IL-15	IL-15R alpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Exogenous IL-15 in combination with IL-15R_alpha rescues natural killer cells from apoptosis induced by chronic alcohol consumption .
21041729	0	IL-15	63,68	IL-15Ra	69,76	IL-15	IL-15Ra	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY control|dobj|response class|acl:relcl|control class|dep|END_ENTITY	MHC class I and TCR avidity control the CD8 T cell response to IL-15 / IL-15Ra complex .
22447977	0	IL-15	0,5	IL-15Ra	21,28	IL-15	IL-15Ra	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	signal|nsubj|START_ENTITY signal|nmod|END_ENTITY	IL-15 can signal via IL-15Ra , JNK , and NF-kB to drive RANTES production by myeloid cells .
22496150	0	IL-15	12,17	IL-15Ra	63,70	IL-15	IL-15Ra	3600	3601	Gene	Gene	exists|nsubj|START_ENTITY exists|nmod|END_ENTITY	Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ra in human and mouse serum .
22593619	0	IL-15	141,146	IL-15Ra	10,17	IL-15	IL-15Ra	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	critical|nmod|START_ENTITY critical|nsubj|expression expression|compound|END_ENTITY	Augmented IL-15Ra expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice .
22767572	0	IL-15	8,13	IL-15Ra	14,21	IL-15	IL-15Ra	3600	3601	Gene	Gene	complexes|dep|START_ENTITY complexes|compound|END_ENTITY	Soluble IL-15 / IL-15Ra complexes in human serum .
22961781	0	IL-15	57,62	IL-15Ra	74,81	IL-15	IL-15Ra	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	superagonist|nmod|START_ENTITY Design|nmod|superagonist fused|nsubj|Design fused|nmod|END_ENTITY	Design and characterization of a protein superagonist of IL-15 fused with IL-15Ra and a high-affinity T cell receptor .
23074221	0	IL-15	45,50	IL-15Ra	94,101	IL-15	IL-15Ra	3600	3601	Gene	Gene	functions|nmod|START_ENTITY mediated|nsubjpass|functions mediated|nmod|versions versions|nmod|END_ENTITY	Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Ra in human monocytes and dendritic cells .
23649624	0	IL-15	75,80	IL-15Ra	82,89	IL-15	IL-15Ra	3600	3601	Gene	Gene	properties|nmod|START_ENTITY favorable|nmod|properties END_ENTITY|amod|favorable	Characterization and favorable in vivo properties of heterodimeric soluble IL-15 IL-15Ra cytokine compared to IL-15 monomer .
24912180	1	IL-15	93,98	IL-15Ra	6,13	IL-15	IL-15Ra	3600	3601	Gene	Gene	survival|nmod|START_ENTITY essential|nmod|survival essential|nsubj|complex complex|amod|END_ENTITY	IL-15Ra complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells .
25399821	0	IL-15	105,110	IL-15Ra	111,118	IL-15	IL-15Ra	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	The natural killer cell dysfunction of aged mice is due to the bone marrow_stroma and is not restored by IL-15 / IL-15Ra treatment .
25941592	0	IL-15	64,69	IL-15Ra	70,77	IL-15	IL-15Ra	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	liver_cancer|nmod|START_ENTITY protein|nmod|liver_cancer protein|amod|END_ENTITY	Immunotherapy of metastatic and autochthonous liver_cancer with IL-15 / IL-15Ra fusion protein .
25964490	0	IL-15	75,80	IL-15Ra	81,88	IL-15	IL-15Ra	3600	3601	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	IRF-1 Promotes Liver Transplant Ischemia/Reperfusion Injury via Hepatocyte IL-15 / IL-15Ra Production .
10463949	0	IL-15	17,22	IL-15Ralpha	104,115	IL-15	IL-15Ralpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|recruitment recruitment|nmod|chain chain|compound|END_ENTITY	Death deflected : IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain .
11064452	0	IL-15	0,5	IL-15Ralpha	104,115	IL-15	IL-15Ralpha	3600	3601	Gene	Gene	START_ENTITY|appos|intracellular intracellular|nmod|END_ENTITY	IL-15 / IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha .
11064452	0	IL-15	0,5	IL-15Ralpha	6,17	IL-15	IL-15Ralpha	3600	3601	Gene	Gene	START_ENTITY|appos|intracellular intracellular|nsubj|END_ENTITY	IL-15 / IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha .
17056533	0	IL-15	51,56	IL-15Ralpha	15,26	IL-15	IL-15Ralpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY maximizes|dobj|activity maximizes|nsubj|END_ENTITY	Combined IL-15 / IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo .
17056533	0	IL-15	9,14	IL-15Ralpha	15,26	IL-15	IL-15Ralpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|maximizes maximizes|nsubj|END_ENTITY	Combined IL-15 / IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo .
17202253	0	IL-15	4,9	IL-15Ralpha	10,21	IL-15	IL-15Ralpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|enables enables|nsubj|END_ENTITY	The IL-15 / IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells .
17202253	0	IL-15	57,62	IL-15Ralpha	10,21	IL-15	IL-15Ralpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY enables|dobj|activity enables|nsubj|END_ENTITY	The IL-15 / IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells .
17327231	0	IL-15	129,134	IL-15Ralpha	20,31	IL-15	IL-15Ralpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	generated|nmod|START_ENTITY generated|nsubjpass|END_ENTITY	Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15 .
18458113	0	IL-15	23,28	IL-15Ralpha	0,11	IL-15	IL-15Ralpha	3600	3601	Gene	Gene	chaperones|xcomp|START_ENTITY chaperones|nsubj|END_ENTITY	IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation .
18656487	0	IL-15	107,112	IL-15Ralpha	144,155	IL-15	IL-15Ralpha	3600	3601	Gene	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha .
18796634	0	IL-15	4,9	IL-15Ralpha	75,86	IL-15	IL-15Ralpha	16168(Tax:10090)	16169(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY chain|nsubj|receptor chain|ccomp|critical critical|nmod|function function|compound|END_ENTITY	The IL-15 receptor -LCB- alpha -RCB- chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation .
21098276	0	IL-15	114,119	IL-15Ralpha	120,131	IL-15	IL-15Ralpha	3600	3601	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15 / IL-15Ralpha complexes .
18656487	0	IL-15	56,61	IL-15ralpha	29,40	IL-15	IL-15ralpha	3600	3601	Gene	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|domain domain|nmod|END_ENTITY	The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha .
17052916	0	IL-15	32,37	IL-18	0,5	IL-15	IL-18	3600	3606	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation .
10072521	0	IL-15	16,21	IL-2	96,100	IL-15	IL-2	25670(Tax:10116)	116562(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|dep|inability inability|acl|replace replace|nmod|END_ENTITY	A novel role of IL-15 in the development of osteoclasts : inability to replace its activity with IL-2 .
10491011	0	IL-15	15,20	IL-2	198,202	IL-15	IL-2	3600	3558	Gene	Gene	spastic_paraparesis|amod|START_ENTITY Involvement|nmod|spastic_paraparesis Involvement|dep|implications implications|nmod|therapy therapy|nmod|antibody antibody|acl|directed directed|nmod|receptor receptor|amod|END_ENTITY	Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic_paraparesis : implications for therapy with a monoclonal antibody directed to the IL-2 / 15R beta receptor .
10820241	0	IL-15	66,71	IL-2	61,65	IL-15	IL-2	3600	3558	Gene	Gene	signals|compound|START_ENTITY allows|nsubj|signals expression|parataxis|allows expression|acl:relcl|delivers delivers|xcomp|END_ENTITY	Constitutive expression of a chimeric receptor that delivers IL-2 / IL-15 signals allows antigen-independent proliferation of CD8 + CD44high but not other T cells .
12370344	0	IL-15	160,165	IL-2	155,159	IL-15	IL-2	16168(Tax:10090)	16183(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Enforced expression of Bcl-2 restores the number of NK cells , but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes , in IL-2 / IL-15 receptor beta-chain-deficient mice .
15308379	0	IL-15	0,5	IL-2	21,25	IL-15	IL-2	699616(Tax:9544)	708017(Tax:9544)	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus_macaques .
15353479	0	IL-15	55,60	IL-2	23,27	IL-15	IL-2	3600	3558	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|compound|END_ENTITY	Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice .
15893691	0	IL-15	19,24	IL-2	14,18	IL-15	IL-2	3600	3558	Gene	Gene	induction|compound|START_ENTITY enhance|nsubj|induction END_ENTITY|parataxis|enhance	Combinational IL-2 / IL-15 induction does not further enhance IL-15-induced lymphokine-activated killer cell cytotoxicity against human leukemia/lymphoma cells .
18573173	0	IL-15	45,50	IL-2	39,43	IL-15	IL-2	16168(Tax:10090)	16183(Tax:10090)	Gene	Gene	treatment|dep|START_ENTITY treatment|compound|END_ENTITY	Expanded donor natural killer cell and IL-2 , IL-15 treatment efficacy in allogeneic hematopoietic stem cell transplantation .
19198835	0	IL-15	97,102	IL-2	205,209	IL-15	IL-2	16168(Tax:10090)	16183(Tax:10090)	Gene	Gene	ionomycin|nmod|START_ENTITY activated|nmod|ionomycin lymphocytes|acl|activated Incubation|nmod|lymphocytes increases|nsubj|Incubation increases|dobj|yield yield|nmod|cells cells|amod|capable capable|advcl|inducing inducing|advcl|culture culture|nmod|END_ENTITY	Incubation of antigen-sensitized T lymphocytes activated with bryostatin_1 + ionomycin in IL-7 _ + _ IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2 .
21518488	0	IL-15	26,31	IL-2	21,25	IL-15	IL-2	3600	3558	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	-LSB- Cytotoxic effect of IL-2 / IL-15 stimulated cord blood derived NK cells on K562/Jurkat cell lines -RSB- .
21867635	0	IL-15	58,63	IL-2	53,57	IL-15	IL-2	3600	3558	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	-LSB- Expression of perforin in cord blood NK cells after IL-2 / IL-15 stimulation and its relation with cytotoxicity -RSB- .
23328843	0	IL-15	5,10	IL-2	0,4	IL-15	IL-2	3600	3558	Gene	Gene	activate|nsubj|START_ENTITY END_ENTITY|appos|activate	IL-2 / IL-15 activate the human clonally restricted KIR3DL1 reverse promoter .
23805138	0	IL-15	0,5	IL-2	76,80	IL-15	IL-2	16168(Tax:10090)	16183(Tax:10090)	Gene	Gene	Accrual|compound|START_ENTITY Accrual|nmod|Face Face|nmod|Levels Levels|compound|END_ENTITY	IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels .
24139475	0	IL-15	90,95	IL-2	52,56	IL-15	IL-2	395258(Tax:9031)	373958(Tax:9031)	Gene	Gene	mature|dobj|START_ENTITY peptide|xcomp|mature peptide|nsubj|Construction Construction|nmod|cytokine cytokine|nmod|fusion fusion|nmod|signal signal|compound|END_ENTITY	Construction of novel cytokine by fusion of chicken IL-2 signal peptide to mature chicken IL-15 and comparison of the adjuvant effects by DNA immunization against Eimeria challenge .
7641685	0	IL-15	38,43	IL-2	115,119	IL-15	IL-2	16168(Tax:10090)	16183(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|acl:relcl|related related|nmod|chain chain|nmod|receptor receptor|compound|END_ENTITY	Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor .
7759955	0	IL-15	0,5	IL-2	88,92	IL-15	IL-2	3600	3558	Gene	Gene	START_ENTITY|appos|factor factor|acl:relcl|shares shares|nmod|END_ENTITY	IL-15 , a novel T cell growth factor that shares activities and receptor components with IL-2 .
8568232	1	IL-15	82,87	IL-2	149,153	IL-15	IL-2	3600	3558	Gene	Gene	START_ENTITY|dep|_ _|ccomp|stable stable|nmod|END_ENTITY	The IL-15 / beta/gamma _ c receptor-ligand complex is less stable than the IL-2 / beta/gamma _ c receptor-ligand complex .
9596675	0	IL-15	123,128	IL-2	39,43	IL-15	IL-2	3600	3558	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells lines|dep|expression replace|nmod|lines replace|dobj|signal signal|compound|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- can replace the IL-2 signal in IL-2-dependent adult_T-cell_leukemia -LRB- ATL -RRB- cell lines : expression of IL-15 receptor alpha on ATL cells .
9596675	0	IL-15	16,21	IL-2	39,43	IL-15	IL-2	3600	3558	Gene	Gene	Interleukin-15|appos|START_ENTITY replace|nsubj|Interleukin-15 replace|dobj|signal signal|compound|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- can replace the IL-2 signal in IL-2-dependent adult_T-cell_leukemia -LRB- ATL -RRB- cell lines : expression of IL-15 receptor alpha on ATL cells .
22785229	0	IL-15	0,5	IL-21	27,32	IL-15	IL-21	3600	59067	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	IL-15 positively regulates IL-21 production in celiac disease mucosa .
27031950	0	IL-15	97,102	IL-22	76,81	IL-15	IL-22	3600	50616	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Memory-Like Antigen-Specific Human NK Cells from TB Pleural Fluids Produced IL-22 in Response to IL-15 or Mycobacterium tuberculosis Antigens .
8612353	0	IL-15	0,5	IL-2Ralpha	37,47	IL-15	IL-2Ralpha	3600	3559	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	IL-15 induces the release of soluble IL-2Ralpha from human peripheral blood mononuclear cells .
26878649	0	IL-15	18,23	IL-6	5,9	IL-15	IL-6	3600	3569	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	High IL-6 and low IL-15 levels mark the presence of TB_infection : A preliminary study .
24790790	0	IL-15	71,76	IL-7	66,70	IL-15	IL-7	3600	3574	Gene	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	Sustained CD4 -LRB- + -RRB- T cell-driven lymphopenia without a compensatory IL-7 / IL-15 response among high-grade glioma patients treated with radiation and temozolomide .
22539288	0	IL-15	0,5	IL-7Ra	15,21	IL-15	IL-7Ra	16168(Tax:10090)	16197(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-15 inhibits IL-7Ra expression by memory-phenotype CD8 T cells in the bone marrow .
25412359	0	IL-15	76,81	IL15Ra	82,88	IL-15	IL15Ra	3600	3601	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	NK cell activation in human hantavirus_infection explained by virus-induced IL-15 / IL15Ra expression .
26646698	0	IL-15	12,17	NKG2D	4,9	IL-15	NKG2D	3600	22914	Gene	Gene	signaling|compound|START_ENTITY contributes|nsubj|signaling END_ENTITY|parataxis|contributes	The NKG2D - IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory_myopathies .
12928391	0	IL-15	45,50	Suppressor_of_cytokine_signaling_1	0,34	IL-15	Suppressor of cytokine signaling 1	16168(Tax:10090)	12703(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY regulates|dobj|receptor regulates|nsubj|END_ENTITY	Suppressor_of_cytokine_signaling_1 regulates IL-15 receptor signaling in CD8 + CD44high memory T lymphocytes .
17324400	0	IL-15	36,41	TGF-beta	14,22	IL-15	TGF-beta	3600	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of TGF-beta signaling by IL-15 : a new role for IL-15 in the loss of immune homeostasis in celiac_disease .
17324400	0	IL-15	58,63	TGF-beta	14,22	IL-15	TGF-beta	3600	7040	Gene	Gene	role|nmod|START_ENTITY Inhibition|dep|role Inhibition|nmod|END_ENTITY	Inhibition of TGF-beta signaling by IL-15 : a new role for IL-15 in the loss of immune homeostasis in celiac_disease .
23566659	0	IL-15	0,5	TNF-a	26,31	IL-15	TNF-a	3600	7124	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	IL-15 that a regulator of TNF-a in patients with diabetes_mellitus_type_2 .
12496395	0	IL-15	98,103	connective_tissue_growth_factor	55,86	IL-15	connective tissue growth factor	3600	1490	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Human gamma delta-T lymphocytes express and synthesize connective_tissue_growth_factor : effect of IL-15 and TGF-beta_1 and comparison with alpha beta-T lymphocytes .
12237122	0	IL-15	0,5	iNOS	19,23	IL-15	iNOS	3600	4843	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells .
24415300	0	IL-15	35,40	interleukin_15	19,33	IL-15	interleukin 15	3600	3600	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the interleukin_15 -LRB- IL-15 -RRB- gene polymorphisms with the risk of developing ulcerative_colitis in Mexican individuals .
8932977	0	IL-15	81,86	interleukin_15	60,74	IL-15	interleukin 15	3600	3600	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and chromosomal localization of the human interleukin_15 gene -LRB- IL-15 -RRB- .
9180138	0	IL-15	30,35	interleukin_15	14,28	IL-15	interleukin 15	3600	3600	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of interleukin_15 -LRB- IL-15 -RRB- in human rhabdomyosarcoma , osteosarcoma and Ewing 's _ sarcoma .
24973821	0	IL-15	54,59	mTOR	32,36	IL-15	mTOR	3600	21977(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells .
24416335	0	IL-15	0,5	tax	16,19	IL-15	tax	16168(Tax:10090)	21367(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	IL-15 deficient tax mice reveal a role for IL-1a in tumor immunity .
16919968	0	IL-15L	44,50	interleukin-15	23,37	IL-15L	interleukin-15	494451(Tax:7955)	654826(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of an interleukin-15 like -LRB- IL-15L -RRB- gene from zebrafish -LRB- Danio_rerio -RRB- .
12671073	0	IL-15R_alpha	0,12	CD8	27,30	IL-15R alpha	CD8	3601	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-15R_alpha expression on CD8 + T cells is dispensable for T cell memory .
10415615	0	IL-15R_alpha	6,18	IL-15	0,5	IL-15R alpha	IL-15	3601	3600	Gene	Gene	intracellular|nsubj|START_ENTITY END_ENTITY|appos|intracellular	IL-15 / IL-15R_alpha intracellular trafficking in human cells and protection from apoptosis .
15693142	0	IL-15R_alpha	136,148	IL-15	130,135	IL-15R alpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY cells|amod|complex targets|nsubj|cells END_ENTITY|parataxis|targets	Large intestine intraepithelial lymphocytes from Apc + / + and Apc + / Min mice and their modulation by indigestible carbohydrates : the IL-15 / IL-15R_alpha complex and CD4 + CD25 + T cells are the main targets .
16284400	0	IL-15R_alpha	39,51	IL-15	96,101	IL-15R alpha	IL-15	3601	3600	Gene	Gene	START_ENTITY|nmod|agonist agonist|nmod|action action|compound|END_ENTITY	Soluble interleukin-15_receptor_alpha -LRB- IL-15R_alpha -RRB- - sushi as a selective and potent agonist of IL-15 action through IL-15R_beta / gamma .
16284400	1	IL-15R_alpha	157,169	IL-15	149,154	IL-15R alpha	IL-15	3601	3600	Gene	Gene	proteins|compound|START_ENTITY x|dobj|proteins x|nsubj|END_ENTITY	Hyperagonist IL-15 x IL-15R_alpha fusion proteins .
19120059	0	IL-15R_alpha	36,48	IL-15	10,15	IL-15R alpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Exogenous IL-15 in combination with IL-15R_alpha rescues natural killer cells from apoptosis induced by chronic alcohol consumption .
11160322	0	IL-15R_alpha	53,65	Tax	39,42	IL-15R alpha	Tax	3601	6900	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Human_T_cell_lymphotropic_virus_type_I Tax activates IL-15R_alpha gene expression through an NF-kappa_B site .
22593619	0	IL-15Ra	10,17	CD40	32,36	IL-15Ra	CD40	16169(Tax:10090)	21939(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|compound|END_ENTITY	Augmented IL-15Ra expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice .
21041729	0	IL-15Ra	69,76	IL-15	63,68	IL-15Ra	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	class|dep|START_ENTITY class|acl:relcl|control control|dobj|response response|nmod|END_ENTITY	MHC class I and TCR avidity control the CD8 T cell response to IL-15 / IL-15Ra complex .
22447977	0	IL-15Ra	21,28	IL-15	0,5	IL-15Ra	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	signal|nmod|START_ENTITY signal|nsubj|END_ENTITY	IL-15 can signal via IL-15Ra , JNK , and NF-kB to drive RANTES production by myeloid cells .
22496150	0	IL-15Ra	63,70	IL-15	12,17	IL-15Ra	IL-15	3601	3600	Gene	Gene	exists|nmod|START_ENTITY exists|nsubj|END_ENTITY	Circulating IL-15 exists as heterodimeric complex with soluble IL-15Ra in human and mouse serum .
22593619	0	IL-15Ra	10,17	IL-15	141,146	IL-15Ra	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY critical|nsubj|expression critical|nmod|END_ENTITY	Augmented IL-15Ra expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice .
22767572	0	IL-15Ra	14,21	IL-15	8,13	IL-15Ra	IL-15	3601	3600	Gene	Gene	complexes|compound|START_ENTITY complexes|dep|END_ENTITY	Soluble IL-15 / IL-15Ra complexes in human serum .
22961781	0	IL-15Ra	74,81	IL-15	57,62	IL-15Ra	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	fused|nmod|START_ENTITY fused|nsubj|Design Design|nmod|superagonist superagonist|nmod|END_ENTITY	Design and characterization of a protein superagonist of IL-15 fused with IL-15Ra and a high-affinity T cell receptor .
23074221	0	IL-15Ra	94,101	IL-15	45,50	IL-15Ra	IL-15	3601	3600	Gene	Gene	versions|nmod|START_ENTITY mediated|nmod|versions mediated|nsubjpass|functions functions|nmod|END_ENTITY	Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15Ra in human monocytes and dendritic cells .
23649624	0	IL-15Ra	82,89	IL-15	75,80	IL-15Ra	IL-15	3601	3600	Gene	Gene	START_ENTITY|amod|favorable favorable|nmod|properties properties|nmod|END_ENTITY	Characterization and favorable in vivo properties of heterodimeric soluble IL-15 IL-15Ra cytokine compared to IL-15 monomer .
24912180	1	IL-15Ra	6,13	IL-15	93,98	IL-15Ra	IL-15	3601	3600	Gene	Gene	complex|amod|START_ENTITY essential|nsubj|complex essential|nmod|survival survival|nmod|END_ENTITY	IL-15Ra complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells .
25399821	0	IL-15Ra	111,118	IL-15	105,110	IL-15Ra	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	The natural killer cell dysfunction of aged mice is due to the bone marrow_stroma and is not restored by IL-15 / IL-15Ra treatment .
25941592	0	IL-15Ra	70,77	IL-15	64,69	IL-15Ra	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|nmod|liver_cancer liver_cancer|nmod|END_ENTITY	Immunotherapy of metastatic and autochthonous liver_cancer with IL-15 / IL-15Ra fusion protein .
25964490	0	IL-15Ra	81,88	IL-15	75,80	IL-15Ra	IL-15	3601	3600	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	IRF-1 Promotes Liver Transplant Ischemia/Reperfusion Injury via Hepatocyte IL-15 / IL-15Ra Production .
10463949	0	IL-15Ralpha	104,115	IL-15	17,22	IL-15Ralpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	chain|compound|START_ENTITY recruitment|nmod|chain inhibits|nmod|recruitment inhibits|nsubj|END_ENTITY	Death deflected : IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain .
11064452	0	IL-15Ralpha	104,115	IL-15	0,5	IL-15Ralpha	IL-15	3601	3600	Gene	Gene	intracellular|nmod|START_ENTITY END_ENTITY|appos|intracellular	IL-15 / IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha .
11064452	0	IL-15Ralpha	6,17	IL-15	0,5	IL-15Ralpha	IL-15	3601	3600	Gene	Gene	intracellular|nsubj|START_ENTITY END_ENTITY|appos|intracellular	IL-15 / IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha .
17056533	0	IL-15Ralpha	15,26	IL-15	51,56	IL-15Ralpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	maximizes|nsubj|START_ENTITY maximizes|dobj|activity activity|compound|END_ENTITY	Combined IL-15 / IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo .
17056533	0	IL-15Ralpha	15,26	IL-15	9,14	IL-15Ralpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	maximizes|nsubj|START_ENTITY END_ENTITY|parataxis|maximizes	Combined IL-15 / IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo .
17202253	0	IL-15Ralpha	10,21	IL-15	4,9	IL-15Ralpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	enables|nsubj|START_ENTITY END_ENTITY|parataxis|enables	The IL-15 / IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells .
17202253	0	IL-15Ralpha	10,21	IL-15	57,62	IL-15Ralpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	enables|nsubj|START_ENTITY enables|dobj|activity activity|compound|END_ENTITY	The IL-15 / IL-15Ralpha on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells .
17327231	0	IL-15Ralpha	20,31	IL-15	129,134	IL-15Ralpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	generated|nsubjpass|START_ENTITY generated|nmod|END_ENTITY	Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15 .
18458113	0	IL-15Ralpha	0,11	IL-15	23,28	IL-15Ralpha	IL-15	3601	3600	Gene	Gene	chaperones|nsubj|START_ENTITY chaperones|xcomp|END_ENTITY	IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation .
18656487	0	IL-15Ralpha	144,155	IL-15	107,112	IL-15Ralpha	IL-15	3601	3600	Gene	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha .
18796634	0	IL-15Ralpha	75,86	IL-15	4,9	IL-15Ralpha	IL-15	16169(Tax:10090)	16168(Tax:10090)	Gene	Gene	function|compound|START_ENTITY critical|nmod|function chain|ccomp|critical chain|nsubj|receptor receptor|compound|END_ENTITY	The IL-15 receptor -LCB- alpha -RCB- chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation .
21098276	0	IL-15Ralpha	120,131	IL-15	114,119	IL-15Ralpha	IL-15	3601	3600	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15 / IL-15Ralpha complexes .
18656487	0	IL-15ralpha	29,40	IL-15	56,61	IL-15ralpha	IL-15	3601	3600	Gene	Gene	domain|nmod|START_ENTITY contributes|nsubj|domain contributes|xcomp|END_ENTITY	The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha .
10779741	0	IL-16	65,70	CD4	14,17	IL-16	CD4	16170(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	Cutting edge : CD4 is not required for the functional activity of IL-16 .
12191564	0	IL-16	104,109	CD4	21,24	IL-16	CD4	3603	920	Gene	Gene	reference|nmod|START_ENTITY T|dep|reference Relationship|dep|T Relationship|nmod|END_ENTITY	Relationship between CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T cell ratio and T cell activation in multiple_myeloma : reference to IL-16 .
14607889	0	IL-16	14,19	CD4	20,23	IL-16	CD4	16170(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|END_ENTITY	Cutting edge : IL-16 / CD4 preferentially induces Th1 cell migration : requirement of CCR5 .
16455991	0	IL-16	44,49	CD4	50,53	IL-16	CD4	3603	920	Gene	Gene	desensitization|nmod|START_ENTITY CXCR3|acl|desensitization CXCR3|parataxis|dependent dependent|nsubj|signaling signaling|compound|END_ENTITY	Chemokine receptor CXCR3 desensitization by IL-16 / CD4 signaling is dependent on CCR5 and intact membrane cholesterol .
16729885	0	IL-16	14,19	CD4	36,39	IL-16	CD4	3603	920	Gene	Gene	Production|nmod|START_ENTITY correlates|nsubj|Production correlates|nmod|inflammation inflammation|compound|END_ENTITY	Production of IL-16 correlates with CD4 + Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple_sclerosis_lesions .
17624801	0	IL-16	0,5	CD4	62,65	IL-16	CD4	3603	920	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling induces|nmod|END_ENTITY	IL-16 signaling specifically induces STAT6 activation through CD4 .
8757315	0	IL-16	11,16	CD4	0,3	IL-16	CD4	3603	920	Gene	Gene	inhibits|nsubj|START_ENTITY ligand|ccomp|inhibits ligand|nsubj|END_ENTITY	CD4 ligand IL-16 inhibits the mixed lymphocyte reaction .
9176493	0	IL-16	34,39	CD4	6,9	IL-16	CD4	3603	920	Gene	Gene	cDNA|compound|START_ENTITY transfected|nmod|cDNA cells|acl|transfected cells|compound|END_ENTITY	Human CD4 + cells transfected with IL-16 cDNA are resistant to HIV-1_infection : inhibition of mRNA expression .
9300714	0	IL-16	71,76	CD4	29,32	IL-16	CD4	3603	920	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Human mast cells produce the CD4 + T lymphocyte chemoattractant factor , IL-16 .
9498748	0	IL-16	42,47	CD4	26,29	IL-16	CD4	3603	920	Gene	Gene	T|nmod|START_ENTITY T|nsubj|activation activation|nmod|+ +|compound|END_ENTITY	Synergistic activation of CD4 + T cells by IL-16 and IL-2 .
9637499	0	IL-16	0,5	CD4	46,49	IL-16	CD4	3603	920	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|SAPK SAPK|acl|signaling signaling|nmod|macrophages macrophages|compound|END_ENTITY	IL-16 activates the SAPK signaling pathway in CD4 + macrophages .
9802374	0	IL-16	65,70	CD4	25,28	IL-16	CD4	3603	920	Gene	Gene	expression|compound|START_ENTITY +|nmod|expression +|nsubj|Association Association|nmod|END_ENTITY	Association of increased CD4 + T-cell infiltration with increased IL-16 gene expression in atopic_dermatitis .
9973381	0	IL-16	26,31	CD4	37,40	IL-16	CD4	3603	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Processing and release of IL-16 from CD4 + but not CD8 + T cells is activation dependent .
11204252	0	IL-16	71,76	CD8	30,33	IL-16	CD8	3603	925	Gene	Gene	role|amod|START_ENTITY role|nmod|cells cells|nummod|+ +|compound|END_ENTITY	A possible pathogenic role of CD8 + T cells and their derived cytokine , IL-16 , in SLE .
11240037	0	IL-16	78,83	CD8	135,138	IL-16	CD8	3603	925	Gene	Gene	expression|appos|START_ENTITY expression|acl|confined confined|advcl|infiltrating infiltrating|dobj|granulocytes granulocytes|appos|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Human focal cerebral_infarctions induce differential lesional interleukin-16 -LRB- IL-16 -RRB- expression confined to infiltrating granulocytes , CD8 + T-lymphocytes and activated microglia/macrophages .
12191564	0	IL-16	104,109	CD8	28,31	IL-16	CD4	3603	920	Gene	Gene	reference|nmod|START_ENTITY T|dep|reference T|compound|END_ENTITY	Relationship between CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T cell ratio and T cell activation in multiple_myeloma : reference to IL-16 .
21036918	0	IL-16	28,33	CD8	37,40	IL-16	CD8	3603	925	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Effects of tobacco smoke on IL-16 in CD8 + cells from human airways and blood : a key role for oxygen free radicals ?
8598478	0	IL-16	13,18	CD8	81,84	IL-16	CD8	3603	925	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|cells cells|compound|END_ENTITY	Secretion of IL-16 -LRB- lymphocyte_chemoattractant_factor -RRB- from serotonin-stimulated CD8 + T cells in vitro .
20307249	0	IL-16	0,5	CD9	59,62	IL-16	CD9	3603	928	Gene	Gene	effects|compound|START_ENTITY effects|dep|dependence dependence|nmod|END_ENTITY	IL-16 effects on A549 lung epithelial cells : dependence on CD9 as an IL-16 receptor ?
20307249	0	IL-16	69,74	CD9	59,62	IL-16	CD9	3603	928	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	IL-16 effects on A549 lung epithelial cells : dependence on CD9 as an IL-16 receptor ?
18446062	0	IL-16	32,37	IL-17	0,5	IL-16	IL-17	3603	3605	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-17 induces the production of IL-16 in rheumatoid_arthritis .
11240948	0	IL-16	0,5	IL-5	15,19	IL-16	IL-5	3603	3567	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	IL-16 inhibits IL-5 production by antigen-stimulated T cells in atopic subjects .
26161406	0	IL-16	17,22	Interleukin_16	0,14	IL-16	Interleukin 16	3603	3603	Gene	Gene	-|dep|START_ENTITY -|compound|END_ENTITY	Interleukin_16 - -LRB- IL-16 - -RRB- Targeted Ultrasound Imaging Agent Improves Detection of Ovarian_Tumors in Laying Hens , a Preclinical Model of Spontaneous Ovarian_Cancer .
16729885	0	IL-16	14,19	Th1	41,44	IL-16	Th1	3603	51497	Gene	Gene	Production|nmod|START_ENTITY correlates|nsubj|Production correlates|nmod|inflammation inflammation|compound|END_ENTITY	Production of IL-16 correlates with CD4 + Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple_sclerosis_lesions .
11196708	0	IL-16	71,76	interleukin-16	55,69	IL-16	interleukin-16	3603	3603	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new polymorphism in the promoter region of the human interleukin-16 -LRB- IL-16 -RRB- gene .
11240037	0	IL-16	78,83	interleukin-16	62,76	IL-16	interleukin-16	3603	3603	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human focal cerebral_infarctions induce differential lesional interleukin-16 -LRB- IL-16 -RRB- expression confined to infiltrating granulocytes , CD8 + T-lymphocytes and activated microglia/macrophages .
25057039	0	IL-17	37,42	APRIL	0,5	IL-17	APRIL	3605	8741	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|compound|END_ENTITY	APRIL levels strongly correlate with IL-17 in systemic_lupus_erythematosus .
21948371	0	IL-17	20,25	Act1	12,16	IL-17	Act1	16171(Tax:10090)	109776(Tax:10090)	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	Function of Act1 in IL-17 family signaling and autoimmunity .
20140904	0	IL-17	25,30	C5a	11,14	IL-17	C5a	16171(Tax:10090)	15139(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Complement C5a regulates IL-17 by affecting the crosstalk between DC and gammadelta T cells in CLP-induced sepsis .
18523258	0	IL-17	14,19	CCR6	29,33	IL-17	CCR6	3605	1235	Gene	Gene	START_ENTITY|nmod|memory memory|compound|END_ENTITY	Regulation of IL-17 in human CCR6 + effector memory T cells .
23776439	0	IL-17	111,116	CD25	25,29	IL-17	CD25	3605	3559	Gene	Gene	secretion|nmod|START_ENTITY contribute|nmod|secretion T|ccomp|contribute T|nsubj|levels levels|nmod|FoxP3 FoxP3|amod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
16148138	0	IL-17	129,134	CD4	7,10	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY dependent|nmod|levels dependent|nsubj|immunopathology immunopathology|compound|END_ENTITY	Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17 .
17335887	0	IL-17	39,44	CD4	15,18	IL-17	CD4	3605	920	Gene	Gene	produce|dobj|START_ENTITY promotes|xcomp|produce promotes|dobj|cells cells|compound|END_ENTITY	IL-23 promotes CD4 + T cells to produce IL-17 in Vogt-Koyanagi-Harada_disease .
17823984	0	IL-17	94,99	CD4	62,65	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY exacerbates|advcl|produce exacerbates|nmod|response response|compound|END_ENTITY	IL-15 exacerbates collagen-induced_arthritis with an enhanced CD4 + T cell response to produce IL-17 .
18209095	0	IL-17	19,24	CD4	46,49	IL-17	CD4	3605	920	Gene	Gene	START_ENTITY|dep|+ +|nummod|END_ENTITY	Distinct , specific IL-17 - and IL-22-producing CD4 + T cell subsets contribute to the human anti-mycobacterial immune response .
18941193	0	IL-17	149,154	CD4	156,159	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
19017937	0	IL-17	62,67	CD4	82,85	IL-17	CD4	3605	920	Gene	Gene	production|compound|START_ENTITY amplifies|dobj|production amplifies|nmod|cells cells|nummod|END_ENTITY	Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4 + T cells in experimental_autoimmune_encephalomyelitis and in multiple_sclerosis .
19433458	0	IL-17	112,117	CD4	54,57	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expansion|nmod|cells control|dobj|expansion control|nsubj|cells cells|nummod|END_ENTITY	Suppression of murine SLE by oral anti-CD3 : inducible CD4 + CD25-LAP + regulatory T cells control the expansion of IL-17 + follicular helper T cells .
19449310	0	IL-17	64,69	CD4	111,114	IL-17	CD4	3605	920	Gene	Gene	START_ENTITY|nmod|development development|nmod|T T|compound|END_ENTITY	The role of retinoic_acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4 + T cells .
19533748	0	IL-17	38,43	CD4	45,48	IL-17	CD4	3605	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	Pretreatment frequency of circulating IL-17 + CD4 + T-cells , but not Tregs , correlates with clinical response to whole-cell vaccination in prostate_cancer patients .
19616200	0	IL-17	102,107	CD4	11,14	IL-17	CD4	3605	920	Gene	Gene	Foxp3|appos|START_ENTITY granzyme_B|appos|Foxp3 expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19996179	0	IL-17	76,81	CD4	55,58	IL-17	CD4	3605	920	Gene	Gene	production|compound|START_ENTITY lacking|dobj|production lacking|nsubj|cells cells|nummod|END_ENTITY	Human Langerhans cells induce distinct IL-22-producing CD4 + T cells lacking IL-17 production .
20015694	0	IL-17	39,44	CD4	65,68	IL-17	CD4	3605	920	Gene	Gene	expression|compound|START_ENTITY influences|nmod|expression influences|nmod|cells cells|compound|END_ENTITY	Suppressive influences of IFN-alpha on IL-17 expression in human CD4 + T cells .
20080304	0	IL-17	14,19	CD4	63,66	IL-17	CD4	3605	920	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|pathway pathway|nmod|cells cells|compound|END_ENTITY	Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus .
20554330	0	IL-17	75,80	CD4	7,10	IL-17	CD4	3605	920	Gene	Gene	produce|xcomp|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	Memory CD4 + CD127high T cells from patients with multiple_sclerosis produce IL-17 in response to myelin antigens .
20571894	0	IL-17	78,83	CD4	95,98	IL-17	CD4	3605	920	Gene	Gene	START_ENTITY|acl|expressing expressing|dobj|cells cells|compound|END_ENTITY	IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4 + T -LRB- T -LRB- H -RRB- 17 -RRB- cells in the periphery .
20921287	0	IL-17	79,84	CD4	18,21	IL-17	CD4	3605	920	Gene	Gene	cytokine|compound|START_ENTITY produce|dobj|cytokine produce|nsubj|subset subset|nmod|T T|compound|END_ENTITY	A novel subset of CD4 -LRB- + -RRB- T -LRB- H -RRB- 2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic_asthma .
21369705	0	IL-17	43,48	CD4	19,22	IL-17	CD4	3605	920	Gene	Gene	produce|dobj|START_ENTITY +|ccomp|produce +|nsubj|END_ENTITY	Tumor-infiltrating CD4 + Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric_cancer .
21692201	0	IL-17	59,64	CD4	0,3	IL-17	CD4	3605	920	Gene	Gene	levels|nmod|START_ENTITY produce|dobj|levels produce|nsubj|cells cells|compound|END_ENTITY	CD4 T cells from behcet patients produce high levels of IL-17 .
21862617	0	IL-17	106,111	CD4	52,55	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY +|dobj|cells +|nsubj|Induction Induction|nmod|autoimmune_thyroiditis autoimmune_thyroiditis|nmod|depletion depletion|nmod|CD25 CD25|compound|END_ENTITY	Induction of autoimmune_thyroiditis by depletion of CD4 + CD25 + regulatory T cells in thyroiditis-resistant IL-17 , but not interferon-gamma receptor , knockout nonobese diabetic-H2h4 mice .
22005586	0	IL-17	38,43	CD4	70,73	IL-17	CD4	282863(Tax:9913)	407098(Tax:9913)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|T-cells T-cells|compound|END_ENTITY	Parasite limiting macrophages promote IL-17 secretion in naive bovine CD4 T-cells during Neospora caninum infection .
22170065	0	IL-17	100,105	CD4	117,120	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	interleukin-17|appos|START_ENTITY differentiation|nmod|interleukin-17 regulates|nmod|differentiation regulates|parataxis|producing producing|dobj|+ +|compound|END_ENTITY	Transforming growth factor-b protein inversely regulates in vivo differentiation of interleukin-17 -LRB- IL-17 -RRB- - producing CD4 + and CD8 + T cells .
22219644	0	IL-17	71,76	CD4	34,37	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY promotes|dobj|secretion promotes|nsubj|Upregulation Upregulation|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	Upregulation of DR3 expression in CD4 T cells promotes secretion of IL-17 in experimental autoimmune uveitis .
22461525	0	IL-17	55,60	CD4	80,83	IL-17	CD4	3605	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
22464815	0	IL-17	65,70	CD4	85,88	IL-17	CD4	3605	920	Gene	Gene	production|compound|START_ENTITY inducing|dobj|production inducing|nmod|cells cells|compound|END_ENTITY	Mesenchymal stem cells promote neutrophil activation by inducing IL-17 production in CD4 + CD45RO + T cells .
23226194	0	IL-17	82,87	CD4	64,67	IL-22	CD4	50616	920	Gene	Gene	cells|amod|START_ENTITY polarize|nmod|cells polarize|dobj|cells cells|nummod|END_ENTITY	Differential capacity of human skin dendritic cells to polarize CD4 + T cells into IL-17 , IL-21 and IL-22 producing cells .
23776439	0	IL-17	111,116	CD4	19,22	IL-17	CD4	3605	920	Gene	Gene	secretion|nmod|START_ENTITY contribute|nmod|secretion T|ccomp|contribute T|nsubj|levels levels|nmod|FoxP3 FoxP3|amod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
24097227	0	IL-17	42,47	CD4	75,78	IL-17	CD4	3605	920	Gene	Gene	circulating|dobj|START_ENTITY circulating|advcl|secreting secreting|dobj|Foxp3 Foxp3|acl|expressing expressing|dobj|cells cells|compound|END_ENTITY	Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4 + T cells and defective suppressive function of circulating Foxp3 + regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory_bowel_disease patients .
24379058	0	IL-17	84,89	CD4	113,116	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|producing producing|nmod|population population|compound|END_ENTITY	Blockade of IL-6 signal exacerbates acute_inflammatory_bowel_disease via inhibiting IL-17 producing in activated CD4 + Th17 population .
25142300	0	IL-17	103,108	CD4	123,126	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY modulating|dobj|production modulating|nmod|cells cells|compound|END_ENTITY	IL-15-dependent CD8 + CD122 + T cells ameliorate experimental_autoimmune_encephalomyelitis by modulating IL-17 production by CD4 + T cells .
25241192	0	IL-17	41,46	CD4	0,3	IL-17	CD4	3605	920	Gene	Gene	cells|amod|START_ENTITY inhibits|dobj|cells inhibits|nsubj|chimera chimera|nummod|END_ENTITY	CD4 aptamer-RORyt shRNA chimera inhibits IL-17 synthesis by human CD4 -LRB- + -RRB- T cells .
25241192	0	IL-17	41,46	CD4	66,69	IL-17	CD4	3605	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	CD4 aptamer-RORyt shRNA chimera inhibits IL-17 synthesis by human CD4 -LRB- + -RRB- T cells .
25385822	0	IL-17	21,26	CD4	41,44	IL-17	CD4	3605	920	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Chloroquine Promotes IL-17 Production by CD4 + T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells .
25499021	0	IL-17	162,167	CD4	205,208	IL-17	CD4	3605	920	Gene	Gene	FoxP3|amod|START_ENTITY reduce|iobj|FoxP3 reduce|dobj|ratio ratio|nmod|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
26771189	0	IL-17	35,40	CD4	44,47	IL-17	CD4	3605	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|T-Cells T-Cells|compound|END_ENTITY	Upregulated Cellular Expression of IL-17 by CD4 + T-Cells in Osteoporotic Postmenopausal Women .
26832697	0	IL-17	53,58	CD4	47,50	IL-17	CD4	301289(Tax:10116)	24932(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Changes of CD4 -LRB- + -RRB- Foxp3 + regulatory T cells and CD4 -LRB- + -RRB- IL-17 + T cells in acrolein exposure rats -RSB- .
26901413	0	IL-17	0,5	CD4	105,108	IL-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	Induction|compound|START_ENTITY Stimulation|nsubj|Induction Stimulation|nmod|Interaction Interaction|nmod|CD3 CD3|nmod|Cells Cells|compound|END_ENTITY	IL-17 Induction by ArtinM is Due to Stimulation of IL-23_and_IL-1 Release and/or Interaction with CD3 in CD4 + T Cells .
19201830	0	IL-17	94,99	CD8	71,74	IL-17	CD8	3605	925	Gene	Gene	producing|dobj|START_ENTITY characterization|acl|producing characterization|nmod|cells cells|compound|END_ENTITY	Cutting edge : Phenotypic characterization and differentiation of human CD8 + T cells producing IL-17 .
19616200	0	IL-17	102,107	CD8	15,18	IL-17	CD8	3605	925	Gene	Gene	Foxp3|appos|START_ENTITY granzyme_B|appos|Foxp3 expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19953909	0	IL-17	49,54	CD8	44,47	IL-17	CD8	3605	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Possible mechanisms of peripheral elevated CD8 + IL-17 + T cells in rheumatoid_arthritis -RSB- .
21352252	0	IL-17	35,40	CD8	77,80	IL-17	CD8	3605	925	Gene	Gene	T|nsubj|START_ENTITY T|ccomp|suppress suppress|dobj|cells cells|compound|END_ENTITY	Colorectal_cancer-derived Foxp3 -LRB- + -RRB- IL-17 -LRB- + -RRB- T cells suppress tumour-specific CD8 + T cells .
21477350	0	IL-17	29,34	CD8	0,3	IL-17	CD8	3605	925	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|nummod|END_ENTITY	CD8 positive T cells express IL-17 in patients with chronic_obstructive_pulmonary_disease .
22230497	0	IL-17	129,134	CD8	75,78	IL-17	CD8	3605	925	Gene	Gene	-RSB-|compound|START_ENTITY cellcycle|nmod|-RSB- activation|appos|cellcycle -LSB-|nsubj|activation -LSB-|dep|stem stem|nmod|END_ENTITY	-LSB- The effect of human placenta-derived mesenchymal stem cells on cord blood CD8 -LRB- + -RRB- ; T cells activation , cellcycle and secretion of IL-17 -RSB- .
23517930	0	IL-17	23,28	CD8	30,33	IL-17	CD8	3605	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Fraction of IL-10 + and IL-17 + CD8 T cells is increased in MS patients in remission and during a relapse , but is not influenced by immune modulators .
24375061	0	IL-17	0,5	CD8	25,28	IL-17	CD8	3605	925	Gene	Gene	START_ENTITY|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	IL-17 and IL-4 producing CD8 + T cells in tumor draining lymph nodes of breast_cancer patients : positive association with tumor progression .
9878122	0	IL-17	14,19	CD8	50,53	IL-17	CD8	3605	925	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of IL-17 , IFN-gamma and IL-10 in human CD8 -LRB- + -RRB- T cells by cyclic_AMP-dependent signal transduction pathway .
24186876	0	IL-17	46,51	CXCL1	65,70	IL-17	CXCL1	16171(Tax:10090)	14825(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	NADPH oxidase mediates synergistic effects of IL-17 and TNF-a on CXCL1 expression by epithelial cells after lung_ischemia-reperfusion .
18941193	0	IL-17	149,154	CXCR5	167,172	IL-17	CXCR5	16171(Tax:10090)	12145(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
22326959	0	IL-17	29,34	Cxcr2	0,5	IL-17	Cxcr2	16171(Tax:10090)	12765(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Cxcr2 and Cxcl5 regulate the IL-17 / G-CSF axis and neutrophil homeostasis in mice .
26374165	0	IL-17	24,29	Del-1	61,66	IL-17	Del-1	3605	10085	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3b-C / EBPb pathway .
22522772	0	IL-17	16,21	FOXP3	23,28	IL-17	FOXP3	3605	50943	Gene	Gene	+|compound|START_ENTITY presence|nmod|+ presence|dep|cells cells|nummod|END_ENTITY	The presence of IL-17 + / FOXP3 + double-positive cells in periodontitis .
18713984	0	IL-17	46,51	FoxP3	13,18	IL-17	FoxP3	16171(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|amod|START_ENTITY effectors|amod|+ become|xcomp|effectors become|nsubj|cells cells|compound|END_ENTITY	Reprogrammed FoxP3 + T regulatory cells become IL-17 + antigen-specific autoimmune effectors in vitro and in vivo .
23776439	0	IL-17	111,116	FoxP3	32,37	IL-17	FoxP3	3605	50943	Gene	Gene	secretion|nmod|START_ENTITY contribute|nmod|secretion T|ccomp|contribute T|nsubj|levels levels|nmod|END_ENTITY	Elevated levels of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FoxP3 -LRB- + -RRB- T cells in systemic_sclerosis patients contribute to the secretion of IL-17 and immunosuppression_dysfunction .
20952660	0	IL-17	6,11	Foxp3	0,5	IL-17	Foxp3	3605	50943	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Foxp3 + IL-17 + T cells promote development of cancer-initiating_cells in colorectal cancer .
21314287	0	IL-17	16,21	Foxp3	22,27	IL-17	Foxp3	3605	50943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Localization of IL-17 + Foxp3 + T cells in esophageal_cancer .
22455945	0	IL-17	60,65	Foxp3	20,25	IL-17	Foxp3	301289(Tax:10116)	317382(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY -RSB-|dobj|cells cells|acl:relcl|-RSB- END_ENTITY|dobj|cells	-LSB- Changes of CD -LRB- 4 -RRB- -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells and CD -LRB- 4 -RRB- -LRB- + -RRB- IL-17 -LRB- + -RRB- T cells in cigarette smoke-exposed rats -RSB- .
22539291	0	IL-17	71,76	Foxp3	0,5	IL-17	Foxp3	3605	50943	Gene	Gene	production|compound|START_ENTITY IL-6-driven|dobj|production insensitive|xcomp|IL-6-driven insensitive|nsubj|cells cells|compound|END_ENTITY	Foxp3 Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production .
24097227	0	IL-17	42,47	Foxp3	58,63	IL-17	Foxp3	3605	50943	Gene	Gene	circulating|dobj|START_ENTITY circulating|advcl|secreting secreting|dobj|END_ENTITY	Increased prevalence of circulating novel IL-17 secreting Foxp3 expressing CD4 + T cells and defective suppressive function of circulating Foxp3 + regulatory cells support plasticity between Th17 and regulatory T cells in inflammatory_bowel_disease patients .
24744433	0	IL-17	0,5	Foxp3	6,11	IL-17	Foxp3	3605	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-17 + Foxp3 + T cells : an intermediate differentiation stage between Th17 cells and regulatory T cells .
15325804	0	IL-17	20,25	G-CSF	40,45	IL-17	G-CSF	3605	1440	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Regulatory roles of IL-17 and IL-17F in G-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha .
22326959	0	IL-17	29,34	G-CSF	35,40	IL-17	G-CSF	16171(Tax:10090)	100036204(Tax:10090)	Gene	Gene	START_ENTITY|dep|axis axis|amod|END_ENTITY	Cxcr2 and Cxcl5 regulate the IL-17 / G-CSF axis and neutrophil homeostasis in mice .
23791509	0	IL-17	121,126	G-CSF	11,16	IL-17	G-CSF	3605	1440	Gene	Gene	secretion|compound|START_ENTITY restoration|nmod|secretion remission|nmod|restoration therapy|dep|remission therapy|amod|END_ENTITY	Continuous G-CSF therapy for isolated chronic_mucocutaneous_candidiasis : complete clinical remission with restoration of IL-17 secretion .
23991206	0	IL-17	85,90	G-CSF	91,96	IL-17	G-CSF	3605	1440	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	LDL cholesterol modulates human CD34 + HSPCs through effects on proliferation and the IL-17 G-CSF axis .
17555818	0	IL-17	0,5	GM-CSF	47,53	IL-17	GM-CSF	3605	1437	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|effects effects|nmod|END_ENTITY	IL-17 attenuates the anti-apoptotic effects of GM-CSF in human neutrophils .
25135733	0	IL-17	11,16	GRO-a	34,39	IL-17	GRO-a	3605	2919	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of IL-17 on expression of GRO-a and IL-8 in fibroblasts from nasal_polyps .
25024377	0	IL-17	63,68	Hsp90	54,59	IL-17	Hsp90	3605	3320	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling .
10554406	0	IL-17	11,16	ICAM-1	20,26	IL-17	ICAM-1	3605	3383	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of IL-17 on ICAM-1 expression of human bronchial epithelial cells , NCI-H 292 -RSB- .
18941193	0	IL-17	149,154	ICOS	161,165	IL-17	ICOS	16171(Tax:10090)	54167(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
19889730	0	IL-17	14,19	ICOS	0,4	IL-17	ICOS	16171(Tax:10090)	54167(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY promotes|dobj|synthesis promotes|nsubj|END_ENTITY	ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10 - / - mice .
22461525	0	IL-17	55,60	IFN-y	38,43	IL-17	IFN-y	3605	3458	Gene	Gene	cells|amod|START_ENTITY induces|nmod|cells induces|dobj|IL-2 IL-2|compound|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
21169541	0	IL-17	59,64	IL-1	30,34	IL-17	IL-1	3605	3552	Gene	Gene	response|compound|START_ENTITY role|nmod|response role|nmod|END_ENTITY	Cutting edge : crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1 .1 - invariant NKT cells to bacteria .
23271701	0	IL-17	49,54	IL-1	33,37	IL-17	IL-1	3605	3553	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|nmod|responses	The role of inflammasome-derived IL-1 in driving IL-17 responses .
23596310	0	IL-17	0,5	IL-10	129,134	IL-17	IL-10	3605	3586	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids .
25499021	0	IL-17	162,167	IL-10	179,184	IL-17	IL-10	3605	3586	Gene	Gene	FoxP3|amod|START_ENTITY FoxP3|compound|END_ENTITY	Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17 -LRB- + -RRB- RORyt -LRB- + -RRB- / IL-10 -LRB- + -RRB- FoxP3 -LRB- + -RRB- ratio in CD4 -LRB- + -RRB- T cells .
18446062	0	IL-17	0,5	IL-16	32,37	IL-17	IL-16	3605	3603	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	IL-17 induces the production of IL-16 in rheumatoid_arthritis .
22324470	0	IL-17	0,5	IL-17	6,11	IL-17	IL-17	3605	3605	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	IL-17 / IL-17 receptor system in autoimmune_disease : mechanisms and therapeutic potential .
22324470	0	IL-17	6,11	IL-17	0,5	IL-17	IL-17	3605	3605	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	IL-17 / IL-17 receptor system in autoimmune_disease : mechanisms and therapeutic potential .
24962673	0	IL-17	29,34	IL-17	56,61	IL-17	IL-17	3605	3605	Gene	Gene	responses|amod|START_ENTITY responses|compound|END_ENTITY	Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary_sarcoidosis patients with L __ fgren 's _ syndrome .
24962673	0	IL-17	56,61	IL-17	29,34	IL-17	IL-17	3605	3605	Gene	Gene	responses|compound|START_ENTITY responses|amod|END_ENTITY	Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary_sarcoidosis patients with L __ fgren 's _ syndrome .
12097364	0	IL-17	44,49	IL-17D	14,20	IL-17	IL-17D	3605	53342	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Cutting edge : IL-17D , a novel member of the IL-17 family , stimulates cytokine production and inhibits hemopoiesis .
11035433	0	IL-17	46,51	IL-18	39,44	IL-17	IL-18	3605	3606	Gene	Gene	IL-12|dep|START_ENTITY IL-12|compound|END_ENTITY	Elevation of proinflammatory cytokine -LRB- IL-18 , IL-17 , IL-12 -RRB- and Th2 cytokine -LRB- IL-4 -RRB- concentrations in patients with systemic_lupus_erythematosus .
22461525	0	IL-17	55,60	IL-2	47,51	IL-17	IL-2	3605	3558	Gene	Gene	cells|amod|START_ENTITY induces|nmod|cells induces|dobj|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
25272942	0	IL-17	45,50	IL-2	26,30	IL-17	IL-2	3605	3558	Gene	Gene	IFN-gamma|dep|START_ENTITY IFN-gamma|dep|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
19330474	0	IL-17	82,87	IL-22	0,5	IL-17	IL-22	3605	50616	Gene	Gene	are|nsubj|START_ENTITY psoriasis|dep|are alterations|nmod|psoriasis mediators|nmod|alterations mediators|nsubj|END_ENTITY	IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not .
21688259	0	IL-17	70,75	IL-22	83,88	IL-17	IL-22	3605	50616	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets .
23328939	0	IL-17	0,5	IL-22	45,50	IL-17	IL-22	16171(Tax:10090)	50929(Tax:10090)	Gene	Gene	START_ENTITY|appos|independent independent|advmod|END_ENTITY	IL-17 / Th17 mediated synovial_inflammation is IL-22 independent .
25042982	0	IL-17	108,113	IL-22	114,119	IL-17	IL-22	3605	50616	Gene	Gene	environment|compound|START_ENTITY environment|compound|END_ENTITY	Neutrophils in antiretroviral therapy-controlled HIV demonstrate hyperactivation associated with a specific IL-17 / IL-22 environment .
15682457	0	IL-17	37,42	IL-23	0,5	IL-17	IL-23	3605	51561	Gene	Gene	synthesis|compound|START_ENTITY IL-10|dobj|synthesis IL-10|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human .
16339539	0	IL-17	107,112	IL-23	35,40	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	production|compound|START_ENTITY mechanism|nmod|production cells|appos|mechanism production|nmod|cells production|compound|END_ENTITY	Fas_ligand induces cell-autonomous IL-23 production in dendritic cells , a mechanism for Fas_ligand-induced IL-17 production .
16670765	0	IL-17	10,15	IL-23	4,9	IL-17	IL-23	3605	51561	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	The IL-23 / IL-17 axis in inflammation .
17335887	0	IL-17	39,44	IL-23	0,5	IL-17	IL-23	3605	51561	Gene	Gene	produce|dobj|START_ENTITY promotes|xcomp|produce promotes|nsubj|END_ENTITY	IL-23 promotes CD4 + T cells to produce IL-17 in Vogt-Koyanagi-Harada_disease .
17548652	0	IL-17	122,127	IL-23	114,119	IL-17	IL-23	3605	51561	Gene	Gene	axis|nsubj|START_ENTITY mediated|parataxis|axis mediated|nmod|END_ENTITY	The proinflammatory effect of prostaglandin_E2 in experimental inflammatory_bowel_disease is mediated through the IL-23 -- > IL-17 axis .
17785829	0	IL-17	94,99	IL-23	0,5	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	involving|dobj|START_ENTITY enhances|xcomp|involving enhances|nsubj|END_ENTITY	IL-23 enhances host defense against vaccinia_virus infection via a mechanism partly involving IL-17 .
17888176	0	IL-17	43,48	IL-23	0,5	IL-17	IL-23	3605	51561	Gene	Gene	osteoclastogenesis|nmod|START_ENTITY induces|dobj|osteoclastogenesis induces|nsubj|END_ENTITY	IL-23 induces human osteoclastogenesis via IL-17 in vitro , and anti-IL-23 antibody attenuates collagen-induced arthritis in rats .
19247658	0	IL-17	53,58	IL-23	14,19	IL-17	IL-23	3605	51561	Gene	Gene	production|compound|START_ENTITY Expression|nmod|production Expression|nmod|END_ENTITY	Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing_spondylitis .
19247658	0	IL-17	53,58	IL-23	44,49	IL-17	IL-23	3605	51561	Gene	Gene	production|compound|START_ENTITY Expression|nmod|production Expression|nmod|END_ENTITY	Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing_spondylitis .
19380832	0	IL-17	85,90	IL-23	79,84	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Imiquimod-induced psoriasis-like skin_inflammation in mice is mediated via the IL-23 / IL-17 axis .
19542449	0	IL-17	33,38	IL-23	0,5	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons .
19657089	0	IL-17	18,23	IL-23	12,17	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY role|dep|axis role|nmod|END_ENTITY	The role of IL-23 / IL-17 axis in lupus_nephritis .
20392505	0	IL-17	18,23	IL-23	12,17	IL-17	IL-23	3605	51561	Gene	Gene	response|amod|START_ENTITY END_ENTITY|dep|response	Unregulated IL-23 / IL-17 immune response in autoimmune_diseases .
20555351	0	IL-17	65,70	IL-23	59,64	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY plaques|nsubj|axis END_ENTITY|parataxis|plaques	Effective narrow-band UVB radiation therapy suppresses the IL-23 / IL-17 axis in normalized psoriasis plaques .
20951792	0	IL-17	71,76	IL-23	0,5	IL-17	IL-23	3605	51561	Gene	Gene	pathway|amod|START_ENTITY EAE|nmod|pathway induce|dobj|EAE modulated|ccomp|induce modulated|nsubj|END_ENTITY	IL-23 modulated myelin-specific T cells induce EAE via an IFNy driven , IL-17 independent pathway .
22343219	0	IL-17	83,88	IL-23	77,82	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY activation|dep|axis activation|nmod|END_ENTITY	Glycosphingolipids mediate pneumocystis cell wall b-glucan activation of the IL-23 / IL-17 axis in human dendritic cells .
23114581	0	IL-17	18,23	IL-23	12,17	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY Role|dep|axis Role|nmod|END_ENTITY	Role of the IL-23 / IL-17 axis in Crohn 's _ disease .
23180821	0	IL-17	21,26	IL-23	15,20	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	TLR9-dependent IL-23 / IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity_pneumonitis .
23327801	0	IL-17	22,27	IL-23	16,21	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY role|dep|axis role|nmod|END_ENTITY	The role of the IL-23 / IL-17 axis in the pathogenesis of Graves ' _ disease .
23484173	0	IL-17	20,25	IL-23	14,19	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY Role|dep|axis Role|nmod|END_ENTITY	Role of serum IL-23 / IL-17 axis in the relationship between periodontitis and coronary_heart_disease .
23825942	0	IL-17	109,114	IL-23	103,108	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Hepatitis_B_virus induces IL-23 production in antigen presenting cells and causes liver_damage via the IL-23 / IL-17 axis .
23843079	0	IL-17	88,93	IL-23	0,5	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|protection protection|compound|END_ENTITY	IL-23 protection against Plasmodium_berghei infection in mice is partially dependent on IL-17 from macrophages .
23994798	0	IL-17	10,15	IL-23	4,9	IL-17	IL-23	3605	51561	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	The IL-23 / IL-17 axis as a therapeutic target .
24424175	0	IL-17	10,15	IL-23	4,9	IL-17	IL-23	3605	51561	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	The IL-23 / IL-17 axis in psoriatic_arthritis .
24670452	0	IL-17	28,33	IL-23	22,27	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	inflammatory|amod|START_ENTITY axis|amod|inflammatory Effects|dep|axis Effects|nmod|END_ENTITY	-LSB- Effects of emodin on IL-23 / IL-17 inflammatory axis , Th17 cells and viral replication in mice with viral_myocarditis -RSB- .
24978886	0	IL-17	29,34	IL-23	23,28	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	correlates|compound|START_ENTITY expression|dep|correlates expression|nmod|END_ENTITY	Elevated expression of IL-23 / IL-17 pathway-related mediators correlates with exacerbation of pulmonary_inflammation during polymicrobial sepsis .
25046339	0	IL-17	47,52	IL-23	41,46	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	Cascade|compound|START_ENTITY Cascade|compound|END_ENTITY	IL-19 Is a Component of the Pathogenetic IL-23 / IL-17 Cascade in Psoriasis .
25114378	0	IL-17	57,62	IL-23	51,56	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY Overexpression|dep|axis Overexpression|nmod|END_ENTITY	Overexpression and selectively regulatory roles of IL-23 / IL-17 axis in the lesions of oral_lichen_planus .
25385822	0	IL-17	21,26	IL-23	72,77	IL-17	IL-23	3605	51561	Gene	Gene	START_ENTITY|nmod|Cells Cells|nmod|Release Release|compound|END_ENTITY	Chloroquine Promotes IL-17 Production by CD4 + T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells .
25595306	0	IL-17	25,30	IL-23	19,24	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY Involvement|dep|axis Involvement|nmod|END_ENTITY	Involvement of the IL-23 / IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune_arthritis .
25803508	0	IL-17	43,48	IL-23	13,18	IL-17	IL-23	16171(Tax:10090)	83430(Tax:10090)	Gene	Gene	Superior|nmod|START_ENTITY Superior|nsubj|END_ENTITY	Neutralizing IL-23 Is Superior to Blocking IL-17 in Suppressing Intestinal Inflammation in a Spontaneous Murine Colitis Model .
26019446	0	IL-17	20,25	IL-23	26,31	IL-17	IL-23	3605	51561	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|dep|axis axis|compound|END_ENTITY	Contribution of the IL-17 / IL-23 axis to the pathogenesis of inflammatory_bowel_disease .
26151690	0	IL-17	21,26	IL-23	15,20	IL-17	IL-23	3605	51561	Gene	Gene	axis|compound|START_ENTITY insight|dep|axis insight|nmod|END_ENTITY	New insight to IL-23 / IL-17 axis in Iranian_infected adult patients with gastritis : effects of genes polymorphisms on expression of cytokines .
26488809	0	IL-17	13,18	IL-23	38,43	IL-17	IL-23	3605	27178	Gene	Gene	Ai|compound|START_ENTITY Ai|acl|Afraid Afraid|nmod|END_ENTITY	Gut-Busters : IL-17 Ai n't Afraid of No IL-23 .
26653110	0	IL-17	20,25	IL-23	14,19	IL-17	IL-23	3605	51561	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the IL-23 / IL-17 axis for the treatment of psoriasis and psoriatic_arthritis .
26774625	0	IL-17	94,99	IL-23	88,93	IL-17	IL-23	3605	27178	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interleukin-23 may contribute to the pathogenesis of lumbar_disc_herniation through the IL-23 / IL-17 pathway .
27067005	0	IL-17	44,49	IL-23	14,19	IL-17	IL-23	3605	51561	Gene	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production .
24313807	0	IL-17	43,48	IL-23R	35,41	IL-17	IL-23R	3605	149233	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|compound|END_ENTITY	Study of the relationships between IL-23R , IL-17 , IL-21 polymorphisms and serum level of IL-17 , IL-21 with acute graft rejection in iranian liver transplant recipients .
15059275	0	IL-17	0,5	IL-6	28,32	IL-17	IL-6	3605	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	IL-17 induces production of IL-6 and IL-8 in rheumatoid_arthritis synovial fibroblasts via NF-kappaB - and PI3-kinase/Akt-dependent pathways .
19055697	0	IL-17	0,5	IL-6	148,152	IL-17	IL-6	3605	3569	Gene	Gene	eliminates|nsubj|START_ENTITY eliminates|advcl|activating activating|dobj|END_ENTITY	IL-17 eliminates the therapeutic effects of myelin_basic_protein-induced nasal tolerance in experimental_autoimmune_encephalomyelitis by activating IL-6 .
19907660	0	IL-17	97,102	IL-6	103,107	IL-17	IL-6	3605	3569	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17 / IL-6 axis .
20083665	0	IL-17	36,41	IL-6	0,4	IL-17	IL-6	16171(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	IL-6 promotes NK cell production of IL-17 during toxoplasmosis .
20351184	0	IL-17	0,5	IL-6	25,29	IL-17	IL-6	3605	3569	Gene	Gene	enhancement|compound|START_ENTITY enhancement|nmod|END_ENTITY	IL-17 enhancement of the IL-6 signaling cascade in astrocytes .
20615550	0	IL-17	143,148	IL-6	91,95	IL-17	IL-6	16171(Tax:10090)	16193(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY signaling|dobj|pathway STAT3|acl|signaling STAT3|compound|END_ENTITY	Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6 / STAT3 signaling pathway and down-regulation of IL-17 .
22171994	0	IL-17	0,5	IL-6	28,32	IL-17	IL-6	3605	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	IL-17 induces AKT-dependent IL-6 / JAK2/STAT3 activation and tumor progression in hepatocellular_carcinoma .
23862741	0	IL-17	81,86	IL-6	49,53	IL-17	IL-6	3605	3569	Gene	Gene	stimulation|compound|START_ENTITY induced|nmod|stimulation induced|nsubj|role role|nmod|Act1 Act1|nmod|levels levels|compound|END_ENTITY	The role of Act1 , a NF-kB-activating protein , in IL-6 and IL-8 levels induced by IL-17 stimulation in SW982 cells .
24379058	0	IL-17	84,89	IL-6	12,16	IL-17	IL-6	16171(Tax:10090)	16193(Tax:10090)	Gene	Gene	acute_inflammatory_bowel_disease|nmod|START_ENTITY exacerbates|dobj|acute_inflammatory_bowel_disease exacerbates|nsubj|Blockade Blockade|nmod|signal signal|compound|END_ENTITY	Blockade of IL-6 signal exacerbates acute_inflammatory_bowel_disease via inhibiting IL-17 producing in activated CD4 + Th17 population .
25040247	0	IL-17	0,5	IL-6	63,67	IL-17	IL-6	3605	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|chemokines chemokines|amod|END_ENTITY	IL-17 stimulates the production of the inflammatory chemokines IL-6 and IL-8 in human dental pulp fibroblasts .
26089643	0	IL-17	29,34	IL-6	35,39	IL-17	IL-6	3605	3569	Gene	Gene	STAT3/NF-kB|compound|START_ENTITY STAT3/NF-kB|dep|END_ENTITY	Inflammation , cytokines , the IL-17 / IL-6 / STAT3/NF-kB axis , and tumorigenesis .
15743872	0	IL-17	30,35	IL-8	36,40	IL-17	IL-8	3605	3576	Gene	Gene	activation|nmod|START_ENTITY activation|dep|axis axis|compound|END_ENTITY	Intrathecal activation of the IL-17 / IL-8 axis in opticospinal_multiple_sclerosis .
25807214	0	IL-17	16,21	Interleukin-17	0,14	IL-17	Interleukin-17	3605	3605	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Interleukin-17 -LRB- IL-17 -RRB- Inhibitors in the Treatment of Plaque Psoriasis : A Review .
12064845	0	IL-17	167,172	Interleukin_17	0,14	IL-17	Interleukin 17	3605	3605	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin_17 -LRB- IL-17 -RRB- induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation : differential activation of AP-1 members by IL-17 and IL-1beta .
24823639	0	IL-17	55,60	Kras	10,14	IL-17	Kras	3605	3845	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic_neoplasia .
26782821	0	IL-17	0,5	MIP-1a	14,20	IL-17	MIP-1a	16171(Tax:10090)	20302(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-17 induces MIP-1a expression in primary mouse astrocytes via TRPC channel .
17921324	0	IL-17	0,5	MMP-1	17,22	IL-17	MMP-1	3605	4312	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK - and ERK1/2-dependent C/EBP-beta , NF-kappaB , and AP-1 activation .
24613343	0	IL-17	16,21	Oct-1	0,5	IL-17	Oct-1	3605	5451	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells .
17982072	0	IL-17	20,25	PTEN	0,4	IL-17	PTEN	16171(Tax:10090)	19211(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	PTEN down-regulates IL-17 expression in a murine model of toluene_diisocyanate-induced airway_disease .
26925062	0	IL-17	12,17	PTH	67,70	IL-17	PTH	16171(Tax:10090)	19226(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Role|nmod|Cells Role|nmod|END_ENTITY	The Role of IL-17 and TH17 Cells in the Bone Catabolic Activity of PTH .
12165487	0	IL-17	0,5	RANTES	51,57	IL-17	RANTES	3605	6352	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts .
16622035	0	IL-17	66,71	STAT3	0,5	IL-17	STAT3	16171(Tax:10090)	20848(Tax:10090)	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|END_ENTITY	STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice .
24799320	0	IL-17	27,32	Stat3	33,38	IL-17	Stat3	16171(Tax:10090)	20848(Tax:10090)	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Platelet_factor_4 inhibits IL-17 / Stat3 pathway via upregulation of SOCS3 expression in melanoma .
21935461	0	IL-17	44,49	TCF-1	17,22	IL-17	TCF-1	16171(Tax:10090)	21414(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	Critical role of TCF-1 in repression of the IL-17 gene .
22138182	0	IL-17	31,36	Tristetraprolin	0,15	IL-17	Tristetraprolin	3605	7538	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	Tristetraprolin down-regulates IL-17 through mRNA destabilization .
15325633	0	IL-17	0,5	VEGF	40,44	IL-17	VEGF	3605	7422	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|production production|amod|END_ENTITY	IL-17 , IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes .
21798287	0	IL-17	0,5	cadherin-11	16,27	IL-17	cadherin-11	16171(Tax:10090)	12552(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	IL-17 increases cadherin-11 expression in a model of autoimmune_experimental_arthritis and in rheumatoid_arthritis .
22229441	0	IL-17	0,5	filaggrin	20,29	IL-17	filaggrin	3605	2312	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion .
23448394	0	IL-17	118,123	interleukin-17	14,28	IL-17	interleukin-17	3605	3605	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of interleukin-17 associated with disease progression and liver_fibrosis with hepatitis_B_virus infection : IL-17 in HBV_infection .
23868508	0	IL-17	112,117	interleukin-17	96,110	IL-17	interleukin-17	3605	3605	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The effect of vitamin_A supplementation on retinoic_acid-related orphan receptor yt -LRB- RORyt -RRB- and interleukin-17 -LRB- IL-17 -RRB- gene expression in Avonex-treated multiple sclerotic patients .
25544504	0	IL-17	0,5	p53	70,73	IL-17	p53	3605	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	IL-17 induces radiation resistance of B_lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis .
23421430	0	IL-17	0,5	vascular_cell_adhesion_molecule	28,59	IL-17	vascular cell adhesion molecule	3605	7412	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	IL-17 induces expression of vascular_cell_adhesion_molecule through signalling pathway of NF-kB , but not Akt1 and TAK1 in vascular smooth muscle cells .
26446668	0	IL-17A	0,6	ADAMTS-7	16,24	IL-17A	ADAMTS-7	3605	11173	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	IL-17A enhances ADAMTS-7 expression through regulation of TNF-a in human nucleus pulposus cells .
21447959	0	IL-17A	0,6	CCL28	15,20	IL-17A	CCL28	3605	56477	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-17A induces CCL28 , supporting the chemotaxis of IgE-secreting B cells .
25058615	0	IL-17A	0,6	CD146	58,63	IL-17A	CD146	3605	4162	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	IL-17A production in human psoriatic blood and lesions by CD146 + T cells .
25790134	0	IL-17A	25,31	CD25	50,54	IL-17A	CD25	16171(Tax:10090)	16184(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|Foxp3 Foxp3|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
20109749	0	IL-17A	94,100	CD4	61,64	IL-17A	CD4	3605	920	Gene	Gene	produce|dobj|START_ENTITY cells|acl:relcl|produce T|dobj|cells T|nsubj|Identification Identification|nmod|subset subset|nmod|END_ENTITY	Identification of a novel subset of human circulating memory CD4 -LRB- + -RRB- T cells that produce both IL-17A and IL-4 .
21959269	0	IL-17A	59,65	CD4	16,19	IL-17A	CD4	3605	920	Gene	Gene	cells|nmod|START_ENTITY T|dobj|cells T|nsubj|END_ENTITY	MCAM-expressing CD4 -LRB- + -RRB- T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune_diseases .
22993203	0	IL-17A	54,60	CD4	75,78	IL-17A	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY activating|dobj|production activating|nmod|T T|compound|END_ENTITY	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
23181791	0	IL-17A	60,66	CD4	80,83	IL-17A	CD4	3605	920	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Human eosinophils release IL-1 and increase expression of IL-17A in activated CD4 + T lymphocytes .
23957337	0	IL-17A	10,16	CD4	27,30	IL-17A	CD4	3605	920	Gene	Gene	START_ENTITY|acl|secreting secreting|dobj|cells cells|nummod|END_ENTITY	Increased IL-17A secreting CD4 + T cells , serum IL-17 levels and exhaled nitric_oxide are correlated with childhood_asthma severity .
24043897	0	IL-17A	32,38	CD4	61,64	IL-17A	CD4	3605	920	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nmod|cells cells|compound|END_ENTITY	Cholera toxin directly enhances IL-17A production from human CD4 + T cells .
25790134	0	IL-17A	25,31	CD4	46,49	IL-17A	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|Foxp3 Foxp3|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
26375594	0	IL-17A	67,73	CD4	94,97	IL-17A	CD4	282863(Tax:9913)	407098(Tax:9913)	Gene	Gene	Production|nmod|START_ENTITY Depends|nmod|Production Depends|nmod|Lymphocytes Lymphocytes|compound|END_ENTITY	Antigen-Specific Mammary Inflammation Depends on the Production of IL-17A and IFN-y by Bovine CD4 + T Lymphocytes .
21124836	0	IL-17A	22,28	CD8	49,52	IL-17A	CD8	3605	925	Gene	Gene	Overrepresentation|nmod|START_ENTITY Overrepresentation|acl|producing producing|dobj|cells cells|compound|END_ENTITY	Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis .
25381766	0	IL-17A	43,49	CD8	65,68	IL-17A	CD8	3605	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Psoriasis and the MAITing game : a role for IL-17A + invariant TCR CD8 + T cells in psoriasis ?
25493691	0	IL-17A	0,6	CD8	34,37	IL-17A	CD8	3605	925	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
20042461	0	IL-17A	0,6	ERK1/2	58,64	IL-17A	ERK1/2	16171(Tax:10090)	26417;26413	Gene	Gene	chemokines|amod|START_ENTITY chemokines|nmod|pathways pathways|dep|END_ENTITY	IL-17A and IL-17F stimulate chemokines via MAPK pathways -LRB- ERK1/2 and p38 but not JNK -RRB- in mouse cultured mesangial cells : synergy with TNF-alpha and IL-1beta .
21993883	0	IL-17A	0,6	ERK1/2	71,77	IL-17A	ERK1/2	3605	5595;5594	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	IL-17A stimulates granulocyte_colony-stimulating_factor production via ERK1/2 but not p38 or JNK in human renal proximal tubular epithelial cells .
25557204	0	IL-17A	0,6	ERK1/2	17,23	IL-17A	ERK1/2	16171(Tax:10090)	26417;26413	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	IL-17A activates ERK1/2 and enhances differentiation of oligodendrocyte progenitor cells .
16951370	0	IL-17A	0,6	Erk1/2	110,116	IL-17A	Erk1/2	3605	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|parataxis|pathways pathways|nsubj|role role|dep|END_ENTITY	IL-17A induces eotaxin-1 / CC chemokine ligand 11 expression in human airway_smooth_muscle cells : role of MAPK -LRB- Erk1/2 , JNK , and p38 -RRB- pathways .
22162626	0	IL-17A	0,6	Erk1/2	63,69	IL-17A	Erk1/2	3605	5595;5594	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|mediators mediators|nmod|END_ENTITY	IL-17A stimulates the production of inflammatory mediators via Erk1/2 , p38 MAPK , PI3K/Akt , and NF-kB pathways in ARPE-19 cells .
18434325	0	IL-17A	34,40	Foxp3	0,5	IL-17A	Foxp3	3605	50943	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat .
25771887	0	IL-17A	55,61	Foxp3	38,43	IL-17A	Foxp3	3605	50943	Gene	Gene	/|iobj|START_ENTITY /|nsubj|role role|nmod|END_ENTITY	The possible role of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- / CD4 -LRB- + -RRB- IL-17A -LRB- + -RRB- cell imbalance in the autoimmunity of patients with Hashimoto_thyroiditis .
25790134	0	IL-17A	25,31	Foxp3	55,60	IL-17A	Foxp3	16171(Tax:10090)	20371(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
21236478	0	IL-17A	74,80	IL-13_receptor	38,52	IL-17A	IL-13 receptor	3605	3598	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Human TH17 cells express a functional IL-13_receptor and IL-13 attenuates IL-17A production .
19542376	0	IL-17A	0,6	IL-17F	16,22	IL-17A	IL-17F	16171(Tax:10090)	257630(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|compound|END_ENTITY	IL-17A controls IL-17F production and maintains blood neutrophil counts in mice .
17644350	0	IL-17A	0,6	IL-17RA	90,97	IL-17A	IL-17RA	3605	23765	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|interference interference|compound|END_ENTITY	IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric_adenocarcinoma cells .
18684971	0	IL-17A	17,23	IL-17RA	67,74	IL-17A	IL-17RA	3605	23765	Gene	Gene	cytokine|compound|START_ENTITY signals|nsubj|cytokine signals|nmod|complex complex|compound|END_ENTITY	The human IL-17F / IL-17A heterodimeric cytokine signals through the IL-17RA / IL-17RC receptor complex .
21109515	0	IL-17A	0,6	IL-17RA	91,98	IL-17A	IL-17RA	3605	23765	Gene	Gene	signal|dep|START_ENTITY signal|nmod|interference interference|compound|END_ENTITY	IL-17A - versus IL-17F-induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in rheumatoid synoviocytes .
22302786	0	IL-17A	4,10	IL-17RA	11,18	IL-17A	IL-17RA	16171(Tax:10090)	16172(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|axis axis|compound|END_ENTITY	The IL-17A / IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment .
23192273	0	IL-17A	0,6	IL-17RA	7,14	IL-17A	IL-17RA	3605	23765	Gene	Gene	START_ENTITY|appos|promoted promoted|nsubj|interaction interaction|compound|END_ENTITY	IL-17A / IL-17RA interaction promoted metastasis of osteosarcoma cells .
27033174	0	IL-17A	4,10	IL-17RA	11,18	IL-17A	IL-17RA	3605	23765	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	The IL-17A / IL-17RA axis in pulmonary_defence and immunopathology .
18684971	0	IL-17A	17,23	IL-17RC	75,82	IL-17A	IL-17RC	3605	84818	Gene	Gene	cytokine|compound|START_ENTITY signals|nsubj|cytokine signals|nmod|complex complex|compound|END_ENTITY	The human IL-17F / IL-17A heterodimeric cytokine signals through the IL-17RA / IL-17RC receptor complex .
22891275	0	IL-17A	80,86	IL-1b	0,5	IL-17A	IL-1b	3605	3553	Gene	Gene	accumulation|nmod|START_ENTITY promoting|dobj|accumulation mediates|advcl|promoting mediates|nsubj|END_ENTITY	IL-1b mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4 -LRB- + -RRB- Th17 cells .
25736459	0	IL-17A	101,107	IL-1b	95,100	IL-17A	IL-1b	16171(Tax:10090)	16176(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1b / IL-17A axis .
20335534	0	IL-17A	55,61	IL-22	63,68	IL-17A	IL-22	3605	50616	Gene	Gene	IL-1|compound|START_ENTITY IL-1|appos|END_ENTITY	Skin_Inflammation Induced by the Synergistic Action of IL-17A , IL-22 , Oncostatin_M , IL-1 -LCB- alpha -RCB- , and TNF - -LCB- alpha -RCB- Recapitulates Some Features of Psoriasis .
20498020	0	IL-17A	90,96	IL-22	44,49	IL-17A	IL-22	16171(Tax:10090)	50929(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Pathological Pathological|nmod|functions functions|nmod|END_ENTITY	Pathological versus protective functions of IL-22 in airway_inflammation are regulated by IL-17A .
21297073	0	IL-17A	75,81	IL-22	13,18	IL-17A	IL-22	16171(Tax:10090)	50929(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Dual Role of IL-22 in allergic_airway_inflammation and its cross-talk with IL-17A .
23505056	0	IL-17A	16,22	IL-22	0,5	IL-17A	IL-22	16171(Tax:10090)	50929(Tax:10090)	Gene	Gene	production|compound|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue_infection .
25133396	0	IL-17A	27,33	IL-2Ra	67,73	IL-17A	IL-2Ra	16171(Tax:10090)	16184(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Differential modulation by IL-17A of Cholangitis_versus_Colitis in IL-2Ra deleted mice .
24788826	0	IL-17A	51,57	IL-37	17,22	IL-17A	IL-37	3605	27178	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of IL-37 and correlation with TNF-a , IL-17A , and disease activity during DMARD treatment of rheumatoid_arthritis .
25493691	0	IL-17A	0,6	IL-4	62,66	IL-17A	IL-4	3605	3565	Gene	Gene	Expression|compound|START_ENTITY Regulated|nsubjpass|Expression Regulated|nmod|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
21305677	0	IL-17A	15,21	IRF4	0,4	IL-17A	IRF4	3605	3662	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	IRF4 regulates IL-17A promoter activity and controls RORyt-dependent Th17 colitis in vivo .
22961652	0	IL-17A	98,104	IRF4	71,75	IL-17A	IRF4	16171(Tax:10090)	16364(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Unlike ab T cells , y T cells , LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22 .
24989845	0	IL-17A	0,6	MIP-1a	15,21	IL-17A	MIP-1a	16171(Tax:10090)	20302(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	IL-17A Induces MIP-1a Expression in Primary Astrocytes via Src/MAPK/PI3K / NF-kB Pathways : Implications for Multiple_Sclerosis .
22627363	0	IL-17A	40,46	NFAT1	0,5	IL-17A	NFAT1	3605	4773	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells .
20335534	0	IL-17A	55,61	Oncostatin_M	70,82	IL-17A	Oncostatin M	3605	5008	Gene	Gene	IL-1|compound|START_ENTITY IL-1|appos|END_ENTITY	Skin_Inflammation Induced by the Synergistic Action of IL-17A , IL-22 , Oncostatin_M , IL-1 -LCB- alpha -RCB- , and TNF - -LCB- alpha -RCB- Recapitulates Some Features of Psoriasis .
22993203	0	IL-17A	54,60	STAT5	32,37	IL-17A	STAT5	16171(Tax:10090)	20850(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
25790134	0	IL-17A	25,31	TLR-2	0,5	IL-17A	TLR-2	16171(Tax:10090)	24088(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
20042461	0	IL-17A	0,6	TNF-alpha	134,143	IL-17A	TNF-alpha	16171(Tax:10090)	21926(Tax:10090)	Gene	Gene	chemokines|amod|START_ENTITY cultured|nsubj|chemokines cultured|dobj|cells cells|dep|synergy synergy|nmod|END_ENTITY	IL-17A and IL-17F stimulate chemokines via MAPK pathways -LRB- ERK1/2 and p38 but not JNK -RRB- in mouse cultured mesangial cells : synergy with TNF-alpha and IL-1beta .
21402950	0	IL-17A	65,71	TNF-alpha	0,9	IL-17A	TNF-alpha	16171(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TNF-alpha from inflammatory dendritic cells -LRB- DCs -RRB- regulates lung IL-17A / IL-5 levels and neutrophilia versus eosinophilia during persistent fungal_infection .
16951370	0	IL-17A	0,6	eotaxin-1	15,24	IL-17A	eotaxin-1	3605	6356	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	IL-17A induces eotaxin-1 / CC chemokine ligand 11 expression in human airway_smooth_muscle cells : role of MAPK -LRB- Erk1/2 , JNK , and p38 -RRB- pathways .
21993883	0	IL-17A	0,6	granulocyte_colony-stimulating_factor	18,55	IL-17A	granulocyte colony-stimulating factor	3605	1440	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	IL-17A stimulates granulocyte_colony-stimulating_factor production via ERK1/2 but not p38 or JNK in human renal proximal tubular epithelial cells .
25146432	0	IL-17A	53,59	interleukin-17A	36,51	IL-17A	interleukin-17A	3605	3605	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Heterogeneous expression pattern of interleukin-17A -LRB- IL-17A -RRB- , IL-17F and their receptors in synovium of rheumatoid_arthritis , psoriatic_arthritis and osteoarthritis : possible explanation for non-response to anti-IL-17 therapy ?
21796151	0	IL-17A	0,6	keratin_17	19,29	IL-17A	keratin 17	16171(Tax:10090)	16667(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	IL-17A upregulates keratin_17 expression in keratinocytes through STAT1 - and STAT3-dependent mechanisms .
22379030	0	IL-17A	0,6	vascular_endothelial_growth_factor	40,74	IL-17A	vascular endothelial growth factor	3605	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IL-17A differentially regulates corneal vascular_endothelial_growth_factor -LRB- VEGF -RRB- - A and soluble VEGF receptor 1 expression and promotes corneal_angiogenesis_after_herpes_simplex_virus_infection .
23555696	0	IL-17A_and_IFN-y	0,16	RNase_7	40,47	IL-17A and IFN-y	RNase 7	3605;3458	84659	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	IL-17A_and_IFN-y synergistically induce RNase_7 expression via STAT3 in primary keratinocytes .
23555696	0	IL-17A_and_IFN-y	0,16	STAT3	63,68	IL-17A and IFN-y	STAT3	3605;3458	6774	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	IL-17A_and_IFN-y synergistically induce RNase_7 expression via STAT3 in primary keratinocytes .
21993849	0	IL-17C	39,45	IL-17RE	0,7	IL-17C	IL-17RE	234836(Tax:10090)	57890(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens .
23834281	0	IL-17C	0,6	IL-17RE	32,39	IL-17C	IL-17RE	27189	132014	Gene	Gene	START_ENTITY|parataxis|identify identify|nsubj|END_ENTITY	IL-17C and its receptor IL-17RA / IL-17RE identify human oral epithelial cell as an inflammatory cell in recurrent aphthous ulcer .
25849644	0	IL-17C	18,24	IL-17RE	25,32	IL-17C	IL-17RE	234836(Tax:10090)	57890(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY END_ENTITY|dep|Signaling	Signaling through IL-17C / IL-17RE Is Dispensable for Immunity to Systemic , Oral and Cutaneous_Candidiasis .
12097364	0	IL-17D	14,20	IL-17	44,49	IL-17D	IL-17	53342	3605	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Cutting edge : IL-17D , a novel member of the IL-17 family , stimulates cytokine production and inhibits hemopoiesis .
27007229	0	IL-17F	92,98	IL-10	64,69	IL-17F	IL-10	112744	3586	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY tumor_necrosis_factor-alpha|appos|END_ENTITY	Cytokine gene polymorphism -LSB- tumor_necrosis_factor-alpha -LRB- -308 -RRB- , IL-10 -LRB- -1082 -RRB- , IL-6 -LRB- -174 -RRB- , IL-17F , 1RaVNTR -RSB- in pediatric patients with primary immune_thrombocytopenia and response to different treatment modalities .
19542376	0	IL-17F	16,22	IL-17A	0,6	IL-17F	IL-17A	257630(Tax:10090)	16171(Tax:10090)	Gene	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	IL-17A controls IL-17F production and maintains blood neutrophil counts in mice .
18088064	0	IL-17F	96,102	IL-17F	32,38	IL-17F	IL-17F	112744	112744	Gene	Gene	expression|compound|START_ENTITY Role|dep|expression Role|nmod|END_ENTITY	Role of the novel Th17 cytokine IL-17F in inflammatory_bowel_disease -LRB- IBD -RRB- : upregulated colonic IL-17F expression in active Crohn 's _ disease and analysis of the IL17F p.His161Arg polymorphism in IBD .
25613064	0	IL-17F	6,12	VEGF	27,31	IL-17F	VEGF	112744	7422	Gene	Gene	combined|nsubj|START_ENTITY combined|nmod|END_ENTITY	Serum IL-17F combined with VEGF as potential diagnostic biomarkers for oral_squamous_cell_carcinoma .
26318043	0	IL-17R	14,20	TPL2	0,4	IL-17R	TPL2	23765	1326	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	TPL2 mediates IL-17R signaling in neuroinflammation .
17644350	0	IL-17RA	90,97	IL-17A	0,6	IL-17RA	IL-17A	23765	3605	Gene	Gene	interference|compound|START_ENTITY induced|nmod|interference induced|nsubj|END_ENTITY	IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric_adenocarcinoma cells .
18684971	0	IL-17RA	67,74	IL-17A	17,23	IL-17RA	IL-17A	23765	3605	Gene	Gene	complex|compound|START_ENTITY signals|nmod|complex signals|nsubj|cytokine cytokine|compound|END_ENTITY	The human IL-17F / IL-17A heterodimeric cytokine signals through the IL-17RA / IL-17RC receptor complex .
21109515	0	IL-17RA	91,98	IL-17A	0,6	IL-17RA	IL-17A	23765	3605	Gene	Gene	interference|compound|START_ENTITY signal|nmod|interference signal|dep|END_ENTITY	IL-17A - versus IL-17F-induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in rheumatoid synoviocytes .
22302786	0	IL-17RA	11,18	IL-17A	4,10	IL-17RA	IL-17A	16172(Tax:10090)	16171(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY plays|nsubj|axis END_ENTITY|parataxis|plays	The IL-17A / IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment .
23192273	0	IL-17RA	7,14	IL-17A	0,6	IL-17RA	IL-17A	23765	3605	Gene	Gene	interaction|compound|START_ENTITY promoted|nsubj|interaction END_ENTITY|appos|promoted	IL-17A / IL-17RA interaction promoted metastasis of osteosarcoma cells .
27033174	0	IL-17RA	11,18	IL-17A	4,10	IL-17RA	IL-17A	23765	3605	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	The IL-17A / IL-17RA axis in pulmonary_defence and immunopathology .
18684971	0	IL-17RA	67,74	IL-17RC	75,82	IL-17RA	IL-17RC	23765	84818	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The human IL-17F / IL-17A heterodimeric cytokine signals through the IL-17RA / IL-17RC receptor complex .
21310253	0	IL-17RA	0,7	IL-6	39,43	IL-17RA	IL-6	16172(Tax:10090)	16193(Tax:10090)	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis .
23106660	0	IL-17RB	118,125	Interleukin-25	0,14	IL-17RB	Interleukin-25	55540	64806	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|nsubj|END_ENTITY	Interleukin-25 promotes basic_fibroblast_growth_factor expression by human endothelial cells through interaction with IL-17RB , but not IL-17RA .
18684971	0	IL-17RC	75,82	IL-17A	17,23	IL-17RC	IL-17A	84818	3605	Gene	Gene	complex|compound|START_ENTITY signals|nmod|complex signals|nsubj|cytokine cytokine|compound|END_ENTITY	The human IL-17F / IL-17A heterodimeric cytokine signals through the IL-17RA / IL-17RC receptor complex .
18684971	0	IL-17RC	75,82	IL-17RA	67,74	IL-17RC	IL-17RA	84818	23765	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The human IL-17F / IL-17A heterodimeric cytokine signals through the IL-17RA / IL-17RC receptor complex .
21993849	0	IL-17RE	0,7	IL-17C	39,45	IL-17RE	IL-17C	57890(Tax:10090)	234836(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens .
23834281	0	IL-17RE	32,39	IL-17C	0,6	IL-17RE	IL-17C	132014	27189	Gene	Gene	identify|nsubj|START_ENTITY END_ENTITY|parataxis|identify	IL-17C and its receptor IL-17RA / IL-17RE identify human oral epithelial cell as an inflammatory cell in recurrent aphthous ulcer .
25849644	0	IL-17RE	25,32	IL-17C	18,24	IL-17RE	IL-17C	57890(Tax:10090)	234836(Tax:10090)	Gene	Gene	START_ENTITY|dep|Signaling Signaling|nmod|END_ENTITY	Signaling through IL-17C / IL-17RE Is Dispensable for Immunity to Systemic , Oral and Cutaneous_Candidiasis .
18320471	0	IL-18	43,48	Angiotensin_subtype_1_receptor	69,99	IL-18	Angiotensin subtype 1 receptor	29197(Tax:10116)	24180(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Mechanical stretch induced interleukin-18 -LRB- IL-18 -RRB- expression through Angiotensin_subtype_1_receptor -LRB- AT1R -RRB- and endothelin-1 in cardiomyocytes .
16772369	0	IL-18	0,5	CD11b	86,91	IL-18	CD11b	16173(Tax:10090)	16409(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	IL-18 produced by thymic epithelial cells induces development of dendritic cells with CD11b in the fetal thymus .
11882036	0	IL-18	14,19	CD30	37,41	IL-18	CD30	3606	943	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of IL-18 on IL-12-induced CD30 expression and IL-4 and IFN-gamma production by allergen and PPD specific T cells .
11035116	0	IL-18	8,13	CD4	17,20	IL-18	CD4	3606	920	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|compound|END_ENTITY	Role of IL-18 in CD4 + T lymphocyte activation in sarcoidosis .
15860230	0	IL-18	14,19	CRH	34,37	IL-18	CRH	16173(Tax:10090)	12918(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of IL-18 expression by CRH in mouse microglial cells .
16804660	0	IL-18	32,37	CRP	124,127	IL-18	CRP	3606	1401	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of interleukin-18 -LRB- IL-18 -RRB- , interleukin-1beta -LRB- IL-1beta -RRB- , its soluble receptor sIL-1RII and C-reactive_protein -LRB- CRP -RRB- in patients with Lyme_arthritis .
17274000	0	IL-18	0,5	CXCL9	47,52	IL-18	CXCL9	3606	4283	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	IL-18 enhances IFN-gamma-induced production of CXCL9 , CXCL10 , and CXCL11 in human keratinocytes .
18803662	0	IL-18	41,46	Corticotropin-releasing_factor	0,30	IL-18	Corticotropin-releasing factor	3606	1392	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Corticotropin-releasing_factor decreases IL-18 in the monocyte-derived dendritic cell .
12594843	0	IL-18	38,43	DC-SIGN	24,31	IL-18	DC-SIGN	3606	30835	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Increased expression of DC-SIGN + IL-12 + IL-18 + and CD83 + IL-12-IL-18 - dendritic cell populations in the colonic mucosa of patients with Crohn 's _ disease .
19737479	0	IL-18	15,20	E-cadherin	24,34	IL-18	E-cadherin	3606	999	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- The effect of IL-18 on E-cadherin expression and its possible intracellular pathway in HK-2 cells -RSB- .
11882913	0	IL-18	68,73	ICAM-1	18,24	IL-18	ICAM-1	3606	3383	Gene	Gene	effect|nmod|START_ENTITY interaction|nmod|effect role|dep|interaction role|nmod|END_ENTITY	Essential role of ICAM-1 / LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC .
15614043	0	IL-18	60,65	ICAM-1	84,90	IL-18	ICAM-1	3606	3383	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes .
15618295	0	IL-18	77,82	ICAM-1	101,107	IL-18	ICAM-1	3606	3383	Gene	Gene	production|nmod|START_ENTITY LFA703|nmod|production effect|nmod|LFA703 effect|nmod|END_ENTITY	Differential effect of LFA703 , pravastatin , and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes .
10925275	0	IL-18	27,32	IFN-alpha	0,9	IL-18	IFN-alpha	3606	3439	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells .
10229825	0	IL-18	0,5	IFN-gamma	96,105	IL-18	IFN-gamma	3606	3458	Gene	Gene	use|nsubj|START_ENTITY use|xcomp|enhance enhance|dobj|production production|nmod|END_ENTITY	IL-18 and CD28 use distinct molecular mechanisms to enhance NK cell production of IL-12-induced IFN-gamma .
10491411	0	IL-18	68,73	IFN-gamma	14,23	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	precursor|compound|START_ENTITY processing|nmod|precursor dependent|nmod|processing dependent|nsubj|END_ENTITY	IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor .
10508240	0	IL-18	98,103	IFN-gamma	69,78	IL-18	IFN-gamma	3606	3458	Gene	Gene	combined|nmod|START_ENTITY enhances|advcl|combined enhances|dobj|proliferation proliferation|nmod|END_ENTITY	IL-10 enhances NK cell proliferation , cytotoxicity and production of IFN-gamma when combined with IL-18 .
10653850	0	IL-18	22,27	IFN-gamma	44,53	IL-18	IFN-gamma	3606	3458	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells .
10679096	0	IL-18	91,96	IFN-gamma	101,110	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	IL-12-independent Th1-type immune responses to respiratory viral_infection : requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes .
10760800	0	IL-18	28,33	IFN-gamma	71,80	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|production production|amod|END_ENTITY	The costimulatory effect of IL-18 on the induction of antigen-specific IFN-gamma production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor beta2 subunit .
10878369	0	IL-18	0,5	IFN-gamma	144,153	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|xcomp|host host|nmod|induction induction|nmod|production production|amod|END_ENTITY	IL-18 contributes to host resistance against infection with Cryptococcus_neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells .
10975835	0	IL-18	23,28	IFN-gamma	0,9	IL-18	IFN-gamma	3606	3458	Gene	Gene	expression|compound|START_ENTITY up-regulates|dep|expression up-regulates|amod|END_ENTITY	IFN-gamma up-regulates IL-18 gene expression via IFN_consensus_sequence-binding_protein and activator protein-1 elements in macrophages .
11046000	0	IL-18	24,29	IFN-gamma	74,83	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	requirements|compound|START_ENTITY requirements|nmod|induction induction|nmod|responses responses|amod|END_ENTITY	Cutting edge : selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral_infection .
11076875	0	IL-18	0,5	IFN-gamma	77,86	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|mice mice|nmod|manner manner|amod|END_ENTITY	IL-18 and IL-12 induce intestinal_inflammation and fatty_liver in mice in an IFN-gamma dependent manner .
11466347	0	IL-18	120,125	IFN-gamma	49,58	IL-18	IFN-gamma	3606	3458	Gene	Gene	complex|amod|START_ENTITY induction|nmod|complex factor|nmod|induction requirement|nmod|factor requirement|nmod|END_ENTITY	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex .
11529897	0	IL-18	36,41	IFN-gamma	0,9	IL-18	IFN-gamma	3606	3458	Gene	Gene	stimulation|amod|START_ENTITY production|nmod|stimulation production|amod|END_ENTITY	IFN-gamma production in response to IL-18 or IL-12 stimulation by peripheral blood mononuclear cells of atopic patients .
11544324	0	IL-18	97,102	IFN-gamma	18,27	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|production production|amod|END_ENTITY	IL-12-independent IFN-gamma production by T cells in experimental Chagas ' _ disease is mediated by IL-18 .
11882913	0	IL-18	68,73	IFN-gamma	87,96	IL-18	IFN-gamma	3606	3458	Gene	Gene	effect|nmod|START_ENTITY interaction|nmod|effect interaction|nmod|production production|amod|END_ENTITY	Essential role of ICAM-1 / LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC .
11960649	0	IL-18	0,5	IFN-gamma	26,35	IL-18	IFN-gamma	3606	3458	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	IL-18 is linked to raised IFN-gamma in multiple_sclerosis and is induced by activated CD4 -LRB- + -RRB- T cells via CD40-CD40 ligand interactions .
12023376	0	IL-18	0,5	IFN-gamma	104,113	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|xcomp|host host|nmod|induction induction|nmod|production production|amod|END_ENTITY	IL-18 contributes to host resistance against infection with Pseudomonas_aeruginosa through induction of IFN-gamma production .
12040407	0	IL-18	56,61	IFN-gamma	72,81	IL-18	IFN-gamma	3606	3458	Gene	Gene	START_ENTITY|nmod|Production Production|compound|END_ENTITY	Asp -LRB- 126 -RRB- , Asp -LRB- 130 -RRB- and Asp -LRB- 134 -RRB- are Necessary for Human IL-18 to Elicit IFN-gamma Production from PBMC .
12067307	0	IL-18	59,64	IFN-gamma	12,21	IL-18	IFN-gamma	3606	3458	Gene	Gene	IL-12|dep|START_ENTITY Profiles|appos|IL-12 Profiles|nmod|END_ENTITY	Profiles of IFN-gamma and its regulatory cytokines -LRB- IL-12 , IL-18 and IL-10 -RRB- in peripheral blood mononuclear cells from patients with multidrug-resistant_tuberculosis .
12193725	0	IL-18	0,5	IFN-gamma	85,94	IL-18	IFN-gamma	29197(Tax:10116)	15978(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|mastocytosis mastocytosis|nmod|END_ENTITY	IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella_spiralis_infection .
12370378	0	IL-18	153,158	IFN-gamma	0,9	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	IFN-gamma production from liver mononuclear cells of mice in burn_injury as well as in postburn bacterial_infection models and the therapeutic effect of IL-18 .
12559970	0	IL-18	47,52	IFN-gamma	23,32	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	LNK5E6|compound|START_ENTITY production|nmod|LNK5E6 production|amod|END_ENTITY	TGFbeta down-regulates IFN-gamma production in IL-18 treated NK cell line LNK5E6 .
15554077	0	IL-18	87,92	IFN-gamma	38,47	IL-18	IFN-gamma	3606	3458	Gene	Gene	effect|nmod|START_ENTITY inhibits|nmod|effect inhibits|dobj|production production|amod|END_ENTITY	T helper 1 inhibitor TAK-603 inhibits IFN-gamma and IL-12 production with no effect on IL-18 : an observation in sarcoidosis patients .
15604417	0	IL-18	0,5	IFN-gamma	62,71	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|dobj|atherosclerosis atherosclerosis|acl|accompanied accompanied|nmod|elevation elevation|nmod|END_ENTITY	IL-18 accelerates atherosclerosis accompanied by elevation of IFN-gamma and CXCL16 expression independently of T cells .
15950732	0	IL-18	35,40	IFN-gamma	51,60	IL-18	IFN-gamma	3606	3458	Gene	Gene	START_ENTITY|xcomp|elicit elicit|dobj|production production|amod|END_ENTITY	Cys74 and Cys163 are necessary for IL-18 to elicit IFN-gamma production from peripheral blood lymphoid mononuclear cells .
16212914	0	IL-18	56,61	IFN-gamma	30,39	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Analysis tissue expression of IFN-gamma in IL-12 and/or IL-18 gene ablated na ve mice .
16785519	0	IL-18	0,5	IFN-gamma	51,60	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	bridges|compound|START_ENTITY innate|nsubj|bridges innate|dobj|immunity immunity|nmod|END_ENTITY	IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway .
17404259	0	IL-18	34,39	IFN-gamma	51,60	IL-18	IFN-gamma	3606	3458	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|secretion secretion|amod|END_ENTITY	Profound enhancement of the IL-12 / IL-18 pathway of IFN-gamma secretion in human CD8 + memory T cell subsets via IL-15 .
17878377	0	IL-18	38,43	IFN-gamma	44,53	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|dep|regulate	ASC/PYCARD and caspase-1 regulate the IL-18 / IFN-gamma axis during Anaplasma_phagocytophilum infection .
9548493	0	IL-18	0,5	IFN-gamma	106,115	IL-18	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|advcl|inducing inducing|dobj|production production|amod|END_ENTITY	IL-18 protects mice against pulmonary_and_disseminated_infection with Cryptococcus_neoformans by inducing IFN-gamma production .
9558078	0	IL-18	130,135	IFN-gamma	105,114	IL-18	IFN-gamma	3606	3458	Gene	Gene	produce|nmod|START_ENTITY produce|dobj|END_ENTITY	Differential capacities of CD4 + , CD8 + , and CD4-CD8 - T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18 .
9759857	0	IL-18	19,24	IFN-gamma	106,115	IL-18	IFN-gamma	3606	3458	Gene	Gene	expression|compound|START_ENTITY expression|dep|synergism synergism|nmod|IL-18 IL-18|nmod|production production|amod|END_ENTITY	IL-12 up-regulates IL-18 receptor expression on T cells , Th1 cells , and B cells : synergism with IL-18 for IFN-gamma production .
9759857	0	IL-18	96,101	IFN-gamma	106,115	IL-18	IFN-gamma	3606	3458	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	IL-12 up-regulates IL-18 receptor expression on T cells , Th1 cells , and B cells : synergism with IL-18 for IFN-gamma production .
9550417	0	IL-18	14,19	IFN-gamma-inducing_factor	21,46	IL-18	IFN-gamma-inducing factor	16173(Tax:10090)	16173(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of IL-18 -LRB- IFN-gamma-inducing_factor -RRB- gene expression .
24756108	0	IL-18	0,5	IFN-y	44,49	IL-18	IFN-y	3606	3458	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	IL-18 , but not IL-12 , induces production of IFN-y in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin .
11377701	0	IL-18	14,19	IFN_gamma	34,43	IL-18	IFN gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Regulation of IL-18 production by IFN_gamma and PGE2 in mouse microglial cells : involvement of NF-kB pathway in the regulatory processes .
19031096	0	IL-18	15,20	IFN_gamma	106,115	IL-18	IFN gamma	3606	3458	Gene	Gene	polymorphism|compound|START_ENTITY Association|nmod|polymorphism Association|dep|effect effect|nmod|polymorphism polymorphism|compound|END_ENTITY	Association of IL-18 gene polymorphism -LRB- -137 C -RRB- with arthritis manifestations in SLE : combined effect with IFN_gamma gene polymorphism -LRB- +874 A -RRB- .
12027422	0	IL-18	130,135	IFNgamma	42,50	IL-18	IFNgamma	3606	3458	Gene	Gene	mechanisms|nmod|START_ENTITY evidence|nmod|mechanisms attenuates|parataxis|evidence attenuates|dobj|responses responses|compound|END_ENTITY	Nitric_oxide attenuates beryllium-induced IFNgamma responses in chronic_beryllium_disease : evidence for mechanisms independent of IL-18 .
16269022	0	IL-18	24,29	IFNgamma	30,38	IL-18	IFNgamma	3606	3458	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Severely impaired IL-12 / IL-18 / IFNgamma axis in patients with hyper_IgE_syndrome .
17292338	0	IL-18	43,48	IFNgamma	12,20	IL-18	IFNgamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY expands|dobj|responses expands|nsubj|END_ENTITY	CpG-induced IFNgamma expands TLR4-specific IL-18 responses in vivo .
19879772	0	IL-18	89,94	IFNgamma	47,55	IL-18	IFNgamma	3606	3458	Gene	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor influence|nmod|regulation influence|dobj|production production|compound|END_ENTITY	TNFalpha and TGF-beta1 influence IL-18-induced IFNgamma production through regulation of IL-18 receptor and T-bet expression .
23028054	0	IL-18	20,25	IL-1	0,4	IL-18	IL-1	3606	3553	Gene	Gene	members|amod|START_ENTITY members|compound|END_ENTITY	IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures .
18841371	0	IL-18	31,36	IL-10	51,56	IL-18	IL-10	16173(Tax:10090)	16153(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY combined|nsubj|effect combined|nmod|END_ENTITY	Therapeutic effect of low-dose IL-18 combined with IL-10 on collagen-induced_arthritis by down-regulation of inflammatory and Th1 responses and induction of Th2 responses .
17052916	0	IL-18	0,5	IL-15	32,37	IL-18	IL-15	3606	3600	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	IL-18 acts synergistically with IL-15 in stimulating natural killer cell proliferation .
11035433	0	IL-18	39,44	IL-17	46,51	IL-18	IL-17	3606	3605	Gene	Gene	IL-12|compound|START_ENTITY IL-12|dep|END_ENTITY	Elevation of proinflammatory cytokine -LRB- IL-18 , IL-17 , IL-12 -RRB- and Th2 cytokine -LRB- IL-4 -RRB- concentrations in patients with systemic_lupus_erythematosus .
11590389	0	IL-18	14,19	IL-18	42,47	IL-18	IL-18	3606	3606	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic_dermatitis .
11590389	0	IL-18	42,47	IL-18	14,19	IL-18	IL-18	3606	3606	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic_dermatitis .
16020503	0	IL-18	20,25	IL-18BP	26,33	IL-18	IL-18BP	3606	10068	Gene	Gene	imbalance|nmod|START_ENTITY imbalance|dep|END_ENTITY	Severe imbalance of IL-18 / IL-18BP in patients with secondary_hemophagocytic_syndrome .
21418867	0	IL-18	9,14	IL-18BP	15,22	IL-18	IL-18BP	3606	10068	Gene	Gene	Role|nmod|START_ENTITY Role|dep|balance balance|compound|END_ENTITY	-LSB- Role of IL-18 / IL-18BP balance in spleen of patients with primary immune_thrombocytopenia -RSB- .
22913567	0	IL-18	67,72	IL-18BP	31,38	IL-18	IL-18BP	3606	10068	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia .
25548255	0	IL-18	26,31	IL-18BP	76,83	IL-18	IL-18BP	3606	10068	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP .
10655506	0	IL-18	100,105	IL-18_binding_protein	67,88	IL-18	IL-18 binding protein	3606	10068	Gene	Gene	inhibit|dobj|START_ENTITY END_ENTITY|acl|inhibit	Structural requirements of six naturally occurring isoforms of the IL-18_binding_protein to inhibit IL-18 .
12022703	0	IL-18	10,15	IL-1beta	19,27	IL-18	IL-1beta	3606	3553	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of IL-18 on IL-1beta and sIL-1RII production by human neutrophils .
16154204	0	IL-18	49,54	IL-1beta	26,34	IL-18	IL-1beta	3606	3553	Gene	Gene	IL-12|dep|START_ENTITY IL-12|compound|END_ENTITY	Proinflammatory cytokine -LRB- IL-1beta , IL-6 , IL-12 , IL-18 and TNF-alpha -RRB- levels in sera of patients with subacute cutaneous lupus_erythematosus -LRB- SCLE -RRB- .
10570181	0	IL-18	0,5	IL-4	70,74	IL-18	IL-4	16173(Tax:10090)	16189(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	IL-18 , although antiallergic when administered with IL-12 , stimulates IL-4 and histamine release by basophils .
11035433	0	IL-18	39,44	IL-4	78,82	IL-18	IL-4	3606	3565	Gene	Gene	IL-12|compound|START_ENTITY cytokine|dep|IL-12 concentrations|amod|cytokine concentrations|appos|END_ENTITY	Elevation of proinflammatory cytokine -LRB- IL-18 , IL-17 , IL-12 -RRB- and Th2 cytokine -LRB- IL-4 -RRB- concentrations in patients with systemic_lupus_erythematosus .
11145671	0	IL-18	0,5	IL-4	15,19	IL-18	IL-4	16173(Tax:10090)	16189(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes : a pro-Th2 effect of IL-18 exerted through NKT cells .
11145671	0	IL-18	88,93	IL-4	15,19	IL-18	IL-4	16173(Tax:10090)	16189(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY exerted|nsubj|effect enhances|parataxis|exerted enhances|dobj|production production|compound|END_ENTITY	IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes : a pro-Th2 effect of IL-18 exerted through NKT cells .
12472176	0	IL-18	10,15	IL-6	34,38	IL-18	IL-6	3606	3569	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of IL-18 on the release of IL-6 and its soluble receptors : sIL-6Ralpha and sgp130 by human neutrophils .
16154204	0	IL-18	49,54	IL-6	36,40	IL-18	IL-6	3606	3569	Gene	Gene	IL-12|dep|START_ENTITY IL-12|dep|END_ENTITY	Proinflammatory cytokine -LRB- IL-1beta , IL-6 , IL-12 , IL-18 and TNF-alpha -RRB- levels in sera of patients with subacute cutaneous lupus_erythematosus -LRB- SCLE -RRB- .
25200954	0	IL-18	0,5	IL-7	22,26	IL-18	IL-7	16173(Tax:10090)	16196(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals .
25780034	0	IL-18	0,5	IL-7	27,31	IL-18	IL-7	16173(Tax:10090)	16196(Tax:10090)	Gene	Gene	Acts|compound|START_ENTITY Acts|nmod|Expansion Expansion|amod|END_ENTITY	IL-18 Acts in Synergy with IL-7 To Promote Ex Vivo Expansion of T Lymphoid Progenitor Cells .
21113894	0	IL-18	43,48	Interleukin-33	0,14	IL-18	Interleukin-33	3606	90865	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Interleukin-33 , a novel member of the IL-1 / IL-18 cytokine family , in cardiology and cardiac surgery .
10998752	0	IL-18	16,21	Interleukin_18	0,14	IL-18	Interleukin 18	3606	3606	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Interleukin_18 -LRB- IL-18 -RRB- levels in patients with sepsis .
15585325	0	IL-18	0,5	SCF	15,18	IL-18	SCF	16173(Tax:10090)	17311(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	IL-18 enhances SCF production of melanoma cells by regulating ROI and p38_MAPK activity .
11466347	0	IL-18	120,125	STAT4	28,33	IL-18	STAT4	3606	6775	Gene	Gene	complex|amod|START_ENTITY induction|nmod|complex factor|nmod|induction requirement|nmod|factor requirement|nmod|END_ENTITY	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex .
19110334	0	IL-18	12,17	TGF-beta1	75,84	IL-18	TGF-beta1	3606	7040	Gene	Gene	expression|compound|START_ENTITY expression|dep|expression expression|amod|END_ENTITY	Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy : TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells .
19110334	0	IL-18	94,99	TGF-beta1	75,84	IL-18	TGF-beta1	3606	7040	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy : TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells .
12684057	0	IL-18	26,31	TNF-alpha	0,9	IL-18	TNF-alpha	3606	7124	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	TNF-alpha and H2O2 induce IL-18 and IL-18R_beta expression in cardiomyocytes via NF-kappa_B activation .
15373921	0	IL-18	17,22	Th1	45,48	IL-18	Th1	3606	51497	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus_nephritis .
15477227	0	IL-18	0,5	Th1	52,55	IL-18	Th1	3606	51497	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|amod|END_ENTITY	IL-18 together with anti-CD3 antibody induces human Th1 cells to produce Th1 - and Th2-cytokines and IL-8 .
18706445	0	IL-18	0,5	ULBP2	15,20	IL-18	ULBP2	3606	80328	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells .
12193723	0	IL-18	135,140	caspase-1	122,131	IL-18	caspase-1	16173(Tax:10090)	12362(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	IL-18 levels and the outcome of innate immune response to lipopolysaccharide : importance of a positive feedback loop with caspase-1 in IL-18 expression .
10623861	0	IL-18	22,27	eotaxin	69,76	IL-18	eotaxin	16173(Tax:10090)	20292(Tax:10090)	Gene	Gene	START_ENTITY|dep|induction induction|nmod|END_ENTITY	Differential roles of IL-18 in allergic_airway_disease : induction of eotaxin by resident cell populations exacerbates eosinophil accumulation .
18003981	0	IL-18	16,21	hypoxia-inducible_factor-1alpha	32,63	IL-18	hypoxia-inducible factor-1alpha	3606	3091	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Hypoxia-induced IL-18 increases hypoxia-inducible_factor-1alpha expression through a Rac1-dependent NF-kappaB pathway .
16652188	0	IL-18	10,15	iNOS	43,47	IL-18	iNOS	3606	51477	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of IL-18 on leukocyte expression of iNOS and phospho-IkB in patients with squamous_cell_carcinoma_of_the_oral_cavity .
26205090	0	IL-18	8,13	insulin	36,43	IL-18	insulin	3606	3630	Gene	Gene	levels|compound|START_ENTITY related|nsubjpass|levels related|nmod|END_ENTITY	-LSB- Plasma IL-18 levels are related to insulin and are modulated by IL-18 gene polymorphisms -RSB- .
26205090	0	IL-18	8,13	insulin	36,43	IL-18	insulin	3606	3630	Gene	Gene	levels|compound|START_ENTITY related|nsubjpass|levels related|nmod|END_ENTITY	-LSB- Plasma IL-18 levels are related to insulin and are modulated by IL-18 gene polymorphisms -RSB- .
10225924	0	IL-18	24,29	interleukin-18	8,22	IL-18	interleukin-18	16173(Tax:10090)	16173(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of interleukin-18 -LRB- IL-18 -RRB- in mycobacterial_infection in IL-18-gene-disrupted mice .
10505749	0	IL-18	31,36	interleukin-18	15,29	IL-18	interleukin-18	3606	3606	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of interleukin-18 -LRB- IL-18 -RRB- in mixed lymphocyte reactions -LRB- MLR -RRB- .
11125306	0	IL-18	30,35	interleukin-18	14,28	IL-18	interleukin-18	3606	3606	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of interleukin-18 -LRB- IL-18 -RRB- expression in keratinocytes -LRB- HaCaT -RRB- : implications for early wound healing .
15809203	0	IL-18	49,54	interleukin-18	33,47	IL-18	interleukin-18	3606	3606	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated systemic levels of free interleukin-18 -LRB- IL-18 -RRB- in patients with Crohn 's _ disease .
18320471	0	IL-18	43,48	interleukin-18	27,41	IL-18	interleukin-18	29197(Tax:10116)	29197(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mechanical stretch induced interleukin-18 -LRB- IL-18 -RRB- expression through Angiotensin_subtype_1_receptor -LRB- AT1R -RRB- and endothelin-1 in cardiomyocytes .
25776473	0	IL-18	47,52	interleukin-18	31,45	IL-18	interleukin-18	3606	3606	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Clinical significance of serum interleukin-18 -LRB- IL-18 -RRB- levels in patients with gastric_cancer .
21557898	0	IL-18	23,28	miR-146a	11,19	IL-18	miR-146a	16173(Tax:10090)	387164(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of miR-146a on IL-18 expression in mouse macrophage -RSB- .
19429811	0	IL-18	0,5	osteopontin	19,30	IL-18	osteopontin	16173(Tax:10090)	20750(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	IL-18 induction of osteopontin mediates cardiac_fibrosis and diastolic_dysfunction in mice .
16650813	0	IL-18	0,5	thrombospondin-1	15,31	IL-18	thrombospondin-1	3606	7057	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	IL-18 enhances thrombospondin-1 production in human gastric_cancer via JNK pathway .
12172382	0	IL-18-binding_protein	119,140	IL-18	22,27	IL-18-binding protein	IL-18	16068(Tax:10090)	3606	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Elevated intracranial IL-18 in humans and mice after traumatic_brain_injury and evidence of neuroprotective effects of IL-18-binding_protein after experimental closed_head_injury .
16020503	0	IL-18BP	26,33	IL-18	20,25	IL-18BP	IL-18	10068	3606	Gene	Gene	imbalance|dep|START_ENTITY imbalance|nmod|END_ENTITY	Severe imbalance of IL-18 / IL-18BP in patients with secondary_hemophagocytic_syndrome .
21418867	0	IL-18BP	15,22	IL-18	9,14	IL-18BP	IL-18	10068	3606	Gene	Gene	balance|compound|START_ENTITY Role|dep|balance Role|nmod|END_ENTITY	-LSB- Role of IL-18 / IL-18BP balance in spleen of patients with primary immune_thrombocytopenia -RSB- .
22913567	0	IL-18BP	31,38	IL-18	67,72	IL-18BP	IL-18	10068	3606	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia .
25548255	0	IL-18BP	76,83	IL-18	26,31	IL-18BP	IL-18	10068	3606	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP .
22836020	0	IL-18Ra	54,61	CD161	47,52	IL-18Ra	CD161	8809	3820	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	Analysis of stem-cell-like properties of human CD161 + + IL-18Ra + memory CD8 + T cells .
10681439	0	IL-18_binding_protein	0,21	IFN-gamma	104,113	IL-18 binding protein	IFN-gamma	10068	3458	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|nmod|inhibition inhibition|nmod|END_ENTITY	IL-18_binding_protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma .
11739524	0	IL-18_binding_protein	26,47	IFN-gamma	63,72	IL-18 binding protein	IFN-gamma	10068	3458	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and release of IL-18_binding_protein in response to IFN-gamma .
11859116	0	IL-18_binding_protein	23,44	IFN-gamma	60,69	IL-18 binding protein	IFN-gamma	10068	3458	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	IL-12 induces monocyte IL-18_binding_protein expression via IFN-gamma .
12482935	0	IL-18_binding_protein	16,37	IFN-gamma	56,65	IL-18 binding protein	IFN-gamma	16068(Tax:10090)	15978(Tax:10090)	Gene	Gene	promoter|nmod|START_ENTITY promoter|acl|activation activation|nmod|END_ENTITY	The promoter of IL-18_binding_protein : activation by an IFN-gamma - induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein beta .
10655506	0	IL-18_binding_protein	67,88	IL-18	100,105	IL-18 binding protein	IL-18	10068	3606	Gene	Gene	START_ENTITY|acl|inhibit inhibit|dobj|END_ENTITY	Structural requirements of six naturally occurring isoforms of the IL-18_binding_protein to inhibit IL-18 .
10673399	0	IL-18_binding_protein	45,66	Interferon-gamma	0,16	IL-18 binding protein	Interferon-gamma	10068	3458	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Interferon-gamma mediates gene expression of IL-18_binding_protein in nonleukocytic cells .
12370360	0	IL-19	0,5	IL-6	28,32	IL-19	IL-6	329244(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha .
12370360	0	IL-19	0,5	TNF-alpha	85,94	IL-19	TNF-alpha	329244(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha .
16778150	0	IL-19	31,36	TNF-alpha	83,92	IL-19	TNF-alpha	29949	7124	Gene	Gene	induce|xcomp|START_ENTITY induce|xcomp|resulting resulting|nmod|increase increase|amod|END_ENTITY	A2B adenosine receptors induce IL-19 from bronchial epithelial cells , resulting in TNF-alpha increase .
11196675	0	IL-19	68,73	interleukin-10	103,117	IL-19	interleukin-10	29949	3586	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Cloning , expression and initial characterization of interleukin-19 -LRB- IL-19 -RRB- , a novel homologue of human interleukin-10 -LRB- IL-10 -RRB- .
18666137	0	IL-1A	25,30	IL-1B	32,37	IL-1A	IL-1B	3552	3553	Gene	Gene	FAS|compound|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
18666137	0	IL-1A	25,30	IL-1RN	39,45	IL-1A	IL-1RN	3552	3557	Gene	Gene	FAS|compound|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
18666137	0	IL-1A	25,30	NFKB1	47,52	IL-1A	NFKB1	3552	4790	Gene	Gene	FAS|compound|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
18666137	0	IL-1B	32,37	IL-1A	25,30	IL-1B	IL-1A	3553	3552	Gene	Gene	FAS|appos|START_ENTITY FAS|compound|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
14522096	0	IL-1B	17,22	IL-1RN	24,30	IL-1B	IL-1RN	3553	3557	Gene	Gene	IL-10|compound|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
18666137	0	IL-1B	32,37	IL-1RN	39,45	IL-1B	IL-1RN	3553	3557	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
14522096	0	IL-1B	17,22	IL-2	32,36	IL-1B	IL-2	3553	3558	Gene	Gene	IL-10|compound|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
14522096	0	IL-1B	17,22	IL-4	38,42	IL-1B	IL-4	3553	3565	Gene	Gene	IL-10|compound|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
14522096	0	IL-1B	17,22	IL-6	44,48	IL-1B	IL-6	3553	3569	Gene	Gene	IL-10|compound|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
23442095	0	IL-1B	35,40	Interleukin_1_beta	15,33	IL-1B	Interleukin 1 beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of Interleukin_1_beta -LRB- IL-1B -RRB- gene polymorphism with early pregnancy_loss risk in the North Indian population .
18666137	0	IL-1B	32,37	NFKB1	47,52	IL-1B	NFKB1	3553	4790	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
12799018	0	IL-1H1	32,38	IL-1Rrp2	0,8	IL-1H1	IL-1Rrp2	56300	8808	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	IL-1Rrp2 expression and IL-1F9 -LRB- IL-1H1 -RRB- actions in brain cells .
19535637	0	IL-1R	0,5	CXCL12	60,66	IL-1R	CXCL12	3554	6387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis .
2148319	0	IL-1R	40,45	interleukin-1_receptor	16,38	IL-1R	interleukin-1 receptor	3554	3554	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of an interleukin-1_receptor -LRB- IL-1R -RRB- on monocytic cells .
22163019	0	IL-1R1	6,12	IL-1a	0,5	IL-1R1	IL-1a	16177(Tax:10090)	16175(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	IL-1a / IL-1R1 expression in chronic_obstructive_pulmonary_disease and mechanistic relevance to smoke-induced neutrophilia in mice .
16015681	0	IL-1R1	116,122	ghrelin	16,23	IL-1R1	ghrelin	16177(Tax:10090)	58991(Tax:10090)	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Enhanced plasma ghrelin levels in Helicobacter_pylori-colonized , interleukin-1-receptor type 1-homozygous knockout -LRB- IL-1R1 - / - -RRB- mice .
25654981	0	IL-1R8	121,127	IL-1	94,98	IL-1R8	IL-1	331461(Tax:10090)	111343(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8 .
8552986	0	IL-1RA	110,116	GM-CSF	165,171	IL-1RA	GM-CSF	3557	1437	Gene	Gene	G-CSF|appos|START_ENTITY erythrocytes|dep|G-CSF Adhesion|nmod|erythrocytes END_ENTITY|nsubj|Adhesion	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1RA	110,116	IL-1-beta	99,108	IL-1RA	IL-1-beta	3557	3553	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|compound|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1RA	110,116	IL-10	130,135	IL-1RA	IL-10	3557	3586	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
24819208	0	IL-1RA	95,101	IL-4	82,86	IL-1RA	IL-4	3557	3565	Gene	Gene	association|dep|START_ENTITY association|nmod|END_ENTITY	Gene polymorphisms and febrile_neutropenia in acute_leukemia -- no association with IL-4 , CCR-5 , IL-1RA , but the MBL-2 , ACE , and TLR-4 are associated with the disease in Turkish patients : a preliminary study .
8836916	0	IL-1RA	60,66	IL-4	26,30	IL-1RA	IL-4	3554	3565	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Dexamethasone antagonizes IL-4 and IL-10-induced release of IL-1RA by monocytes but augments IL-4 - , IL-10 - , and TGF-beta-induced suppression of TNF-alpha release .
8552986	0	IL-1RA	110,116	IL-6	118,122	IL-1RA	IL-6	3557	3569	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1RA	110,116	IL-8	124,128	IL-1RA	IL-8	3557	3576	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1RA	110,116	TGF_beta	137,145	IL-1RA	TGF beta	3557	7040	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	IL-1RA	110,116	TNF_alpha	147,156	IL-1RA	TNF alpha	3557	7124	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
17443229	0	IL-1RA	81,87	interleukin-1-receptor_antagonist	46,79	IL-1RA	interleukin-1-receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variation in the gene encoding interleukin-1-receptor_antagonist -LRB- IL-1RA -RRB- is associated with altered circulating IL-1RA levels .
9870274	0	IL-1RA	47,53	interleukin-1_receptor_antagonist	12,45	IL-1RA	interleukin-1 receptor antagonist	3557	3557	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating interleukin-1_receptor_antagonist -LRB- IL-1RA -RRB- serum levels in patients undergoing orthotopic heart transplantation .
12751790	0	IL-1RI	43,49	IRAK	69,73	IL-1RI	IRAK	3554	3654	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|END_ENTITY	Recruitment of the interleukin-1 receptor -LRB- IL-1RI -RRB- - associated kinase IRAK to the IL-1RI is redox regulated .
19940113	0	IL-1RI	15,21	TILRR	0,5	IL-1RI	TILRR	3554	158326	Gene	Gene	co-receptor|compound|START_ENTITY END_ENTITY|appos|co-receptor	TILRR , a novel IL-1RI co-receptor , potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB .
11196665	0	IL-1RI	125,131	interleukin-1_receptor_type_I	94,123	IL-1RI	interleukin-1 receptor type I	3554	3554	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of novel single nucleotide polymorphisms in intron 1B and exon 1C of the human interleukin-1_receptor_type_I -LRB- IL-1RI -RRB- gene .
11196719	0	IL-1RI	77,83	interleukin-1_receptor_type_I	46,75	IL-1RI	interleukin-1 receptor type I	3554	3554	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A Bsr BI polymorphism in exon 1C of the human interleukin-1_receptor_type_I -LRB- IL-1RI -RRB- gene .
25017307	0	IL-1RL1	22,29	IL-33	16,21	IL-1RL1	IL-33	9173	90865	Gene	Gene	axis|compound|START_ENTITY role|dep|axis role|nmod|END_ENTITY	The role of the IL-33 / IL-1RL1 axis in mast cell and basophil activation in allergic_disorders .
18666137	0	IL-1RN	39,45	IL-1A	25,30	IL-1RN	IL-1A	3557	3552	Gene	Gene	FAS|appos|START_ENTITY FAS|compound|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
14522096	0	IL-1RN	24,30	IL-1B	17,22	IL-1RN	IL-1B	3557	3553	Gene	Gene	IL-10|dep|START_ENTITY IL-10|compound|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
18666137	0	IL-1RN	39,45	IL-1B	32,37	IL-1RN	IL-1B	3557	3553	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
14522096	0	IL-1RN	24,30	IL-2	32,36	IL-1RN	IL-2	3557	3558	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
14522096	0	IL-1RN	24,30	IL-4	38,42	IL-1RN	IL-4	3557	3565	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
14522096	0	IL-1RN	24,30	IL-6	44,48	IL-1RN	IL-6	3557	3569	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
18332090	0	IL-1RN	40,46	Interleukin-1_receptor_antagonist_gene	0,38	IL-1RN	Interleukin-1 receptor antagonist gene	3557	3557	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Interleukin-1_receptor_antagonist_gene -LRB- IL-1RN -RRB- polymorphism is a predictive factor of clinical pregnancy after IVF .
18666137	0	IL-1RN	39,45	NFKB1	47,52	IL-1RN	NFKB1	3557	4790	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
19046297	0	IL-1Ra	8,14	IL-1	15,19	IL-1Ra	IL-1	3557	3552	Gene	Gene	ratio|dep|START_ENTITY ratio|compound|END_ENTITY	Reduced IL-1Ra / IL-1 ratio in ultraviolet B-exposed skin of patients with polymorphic_light_eruption .
11380940	0	IL-1Ra	92,98	IL-1_beta	132,141	IL-1Ra	IL-1 beta	3557	3553	Gene	Gene	gene|appos|START_ENTITY intron|nmod|gene polymorphisms|nmod|intron polymorphisms|dep|definition definition|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Single nucleotide polymorphisms in intron 2 of the human interleukin-1_receptor_antagonist -LRB- IL-1Ra -RRB- gene : further definition of the IL-1_beta and IL-1Ra polymorphisms in North American Caucasians and Taiwanese Chinese .
7586694	0	IL-1Ra	64,70	IL-1_beta	24,33	IL-1Ra	IL-1 beta	3557	3553	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Allelic polymorphism in IL-1_beta and IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- genes in inflammatory_bowel_disease .
9710237	0	IL-1Ra	26,32	IL-1_receptor_antagonist	0,24	IL-1Ra	IL-1 receptor antagonist	3557	3557	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes .
11027520	0	IL-1Ra	88,94	IL-1beta	48,56	IL-1Ra	IL-1beta	3557	3553	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Imbalance production between interleukin-1beta -LRB- IL-1beta -RRB- and IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- in bronchial_asthma .
15020061	0	IL-1Ra	73,79	IL-1beta	64,72	IL-1Ra	IL-1beta	60582(Tax:10116)	24494(Tax:10116)	Gene	Gene	balance|compound|START_ENTITY Influence|dep|balance Influence|nmod|END_ENTITY	Influence of the course of brain_inflammation on the endogenous IL-1beta / IL-1Ra balance in the model of brain_delayed-type_hypersensitivity response to bacillus Calmette-Gu rin in Lewis rats .
15900570	0	IL-1Ra	15,21	IL-1beta	63,71	IL-1Ra	IL-1beta	3557	3553	Gene	Gene	polymorphism|compound|START_ENTITY Association|nmod|polymorphism Association|nmod|association association|nmod|polymorphisms polymorphisms|compound|END_ENTITY	Association of IL-1Ra gene polymorphism , but no association of IL-1beta and IL-4 gene polymorphisms , with Kawasaki_disease .
19618085	0	IL-1Ra	101,107	IL-1beta	52,60	IL-1Ra	IL-1beta	3557	3553	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|expression expression|nmod|END_ENTITY	Evaluation of the expression of interleukin_1_beta -LRB- IL-1beta -RRB- and interleukin_1_receptor_antagonist -LRB- IL-1Ra -RRB- in leprosy patients .
8608647	0	IL-1Ra	55,61	IL-1beta	16,24	IL-1Ra	IL-1beta	3557	3553	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of IL-1beta and IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- in bronchoalveolar lavage fluid -LRB- BALF -RRB- in patients with diffuse_panbronchiolitis -LRB- DPB -RRB- .
10528667	0	IL-1Ra	82,88	IL-6	57,61	IL-1Ra	IL-6	3557	3569	Gene	Gene	IL-1beta|appos|START_ENTITY IL-1beta|appos|END_ENTITY	Whole blood production of monocytic cytokines -LRB- IL-1beta , IL-6 , TNF-alpha , sIL-6R , IL-1Ra -RRB- in haemodialysed patients .
12901852	0	IL-1Ra	14,20	IL-6	50,54	IL-1Ra	IL-6	3557	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38_mitogen-activated_protein_kinase and NF-kappaB pathways .
9135739	0	IL-1Ra	36,42	IL-6	139,143	IL-1Ra	IL-6	3557	3569	Gene	Gene	receptor|amod|START_ENTITY expression|nmod|receptor suppresses|nsubj|expression suppresses|dobj|induction induction|nmod|END_ENTITY	Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10 .
23908665	0	IL-1Ra	56,62	IL-8	64,68	IL-1Ra	IL-8	3557	3576	Gene	Gene	b|amod|START_ENTITY b|amod|END_ENTITY	The role of cytokines in seizures : interleukin _ -LRB- IL -RRB- -1 b , IL-1Ra , IL-8 , and IL-10 .
10528667	0	IL-1Ra	82,88	TNF-alpha	63,72	IL-1Ra	TNF-alpha	3557	7124	Gene	Gene	IL-1beta|appos|START_ENTITY IL-1beta|appos|END_ENTITY	Whole blood production of monocytic cytokines -LRB- IL-1beta , IL-6 , TNF-alpha , sIL-6R , IL-1Ra -RRB- in haemodialysed patients .
11380940	0	IL-1Ra	92,98	interleukin-1_receptor_antagonist	57,90	IL-1Ra	interleukin-1 receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms in intron 2 of the human interleukin-1_receptor_antagonist -LRB- IL-1Ra -RRB- gene : further definition of the IL-1_beta and IL-1Ra polymorphisms in North American Caucasians and Taiwanese Chinese .
11752505	0	IL-1Ra	61,67	interleukin_1_receptor_antagonist	26,59	IL-1Ra	interleukin 1 receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism within the interleukin_1_receptor_antagonist -LRB- IL-1Ra -RRB- gene is associated with ankylosing_spondylitis .
12799018	0	IL-1Rrp2	0,8	IL-1H1	32,38	IL-1Rrp2	IL-1H1	8808	56300	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	IL-1Rrp2 expression and IL-1F9 -LRB- IL-1H1 -RRB- actions in brain cells .
15205567	0	IL-1_RA	81,88	interleukin-1_receptor_antagonist	46,79	IL-1 RA	interleukin-1 receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Body mass index but not a polymorphism of the interleukin-1_receptor_antagonist -LRB- IL-1_RA -RRB- gene is associated with age at natural menopause .
8482924	0	IL-1_alpha	43,53	C-reactive_protein	0,18	IL-1 alpha	C-reactive protein	3552	1401	Gene	Gene	production|nmod|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	C-reactive_protein increases production of IL-1_alpha , IL-1_beta , and TNF-alpha , and expression of mRNA by human alveolar macrophages .
8928088	0	IL-1_alpha	21,31	C4b-binding_protein	57,76	IL-1 alpha	C4b-binding protein	3552	722	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	TNF-alpha suppresses IL-1_alpha and IL-6 upregulation of C4b-binding_protein in HepG-2 hepatoma cells .
24273934	0	IL-1_alpha	0,10	CXCL1	21,26	IL-1 alpha	CXCL1	3552	2919	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IL-1_alpha regulates CXCL1 , CXCL10 and ICAM1 in network form in oral keratinocytes .
1316934	0	IL-1_alpha	50,60	IL-1_beta	36,45	IL-1 alpha	IL-1 beta	16175(Tax:10090)	16176(Tax:10090)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Transition from interleukin_1_beta -LRB- IL-1_beta -RRB- to IL-1_alpha production during maturation of inflammatory macrophages in vivo .
2062178	0	IL-1_alpha	66,76	IL-1_beta	18,27	IL-1 alpha	IL-1 beta	3552	3553	Gene	Gene	production|nmod|START_ENTITY stimulate|dobj|production stimulate|nsubj|END_ENTITY	Recombinant human IL-1_beta and TNF-alpha stimulate production of IL-1_alpha and IL-1_beta by vascular smooth muscle cells and IL-1_alpha by vascular endothelial cells .
2787349	0	IL-1_alpha	97,107	IL-1_beta	125,134	IL-1 alpha	IL-1 beta	3552	3553	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Activation of normal human B cells through their antigen receptor induces membrane expression of IL-1_alpha and secretion of IL-1_beta .
3264804	0	IL-1_alpha	18,28	IL-1_beta	107,116	IL-1 alpha	IL-1 beta	3552	3553	Gene	Gene	Existence|nmod|START_ENTITY Existence|dep|form form|nmod|END_ENTITY	Existence of both IL-1_alpha and beta in normal human amniotic_fluid : unique high molecular weight form of IL-1_beta .
8964658	0	IL-1_alpha	86,96	IL-1_beta	33,42	IL-1 alpha	IL-1 beta	3552	3553	Gene	Gene	production|amod|START_ENTITY converting|nmod|production END_ENTITY|acl|converting	Effect of peptide aldehydes with IL-1_beta converting enzyme inhibitory properties on IL-1_alpha and IL-1_beta production in vitro .
9029492	0	IL-1_alpha	44,54	IL-1_beta	0,9	IL-1 alpha	IL-1 beta	24493(Tax:10116)	24494(Tax:10116)	Gene	Gene	transduces|nmod|START_ENTITY transduces|nsubj|END_ENTITY	IL-1_beta transduces different signals than IL-1_alpha leading to class II antigen expression on beta-insulinoma RIN-5AH cells through specific receptors .
1969882	0	IL-1_alpha	29,39	IL-2	99,103	IL-1 alpha	IL-2	16175(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Growth-promoting activity of IL-1_alpha , IL-6 , and tumor_necrosis_factor-alpha in combination with IL-2 , IL-4 , or IL-7 on murine thymocytes .
3143761	0	IL-1_alpha	34,44	IL-2	0,4	IL-1 alpha	IL-2	3552	3558	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-2 stimulates the production of IL-1_alpha and IL-1_beta by human peripheral blood mononuclear cells .
12954239	0	IL-1_alpha	31,41	IL-4	94,98	IL-1 alpha	IL-4	281250(Tax:9913)	280824(Tax:9913)	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
1402392	0	IL-1_alpha	48,58	IL-6	11,15	IL-1 alpha	IL-6	3552	3569	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Tumor cell IL-6 gene expression is regulated by IL-1_alpha / beta and TNF_alpha : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages .
8287605	0	IL-1_alpha	31,41	PDGF-B	78,84	IL-1 alpha	PDGF-B	16175(Tax:10090)	18591(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Intraglomerular expressions of IL-1_alpha and platelet-derived growth factor -LRB- PDGF-B -RRB- mRNA in experimental immune complex-mediated glomerulonephritis .
12954239	0	IL-1_alpha	31,41	TNF-alpha	49,58	IL-1 alpha	TNF-alpha	281250(Tax:9913)	280943(Tax:9913)	Gene	Gene	START_ENTITY|dep|IFN-gamma IFN-gamma|compound|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
1793017	0	IL-1_alpha	83,93	TNF-alpha	122,131	IL-1 alpha	TNF-alpha	3552	7124	Gene	Gene	assays|nmod|START_ENTITY Development|nmod|assays necrosis|nsubj|Development necrosis|dobj|factor factor|appos|END_ENTITY	Development of high-throughput radioligand binding assays for interleukin-1_alpha -LRB- IL-1_alpha -RRB- and tumor necrosis factor -LRB- TNF-alpha -RRB- in isolated membrane preparations .
7759886	0	IL-1_alpha	66,76	TNF-alpha	78,87	IL-1 alpha	TNF-alpha	24493(Tax:10116)	24835(Tax:10116)	Gene	Gene	reactions|appos|START_ENTITY migration|nmod|reactions monocyte|acl|migration utilizes|nmod|monocyte utilizes|nsubj|END_ENTITY	In vivo blood monocyte migration to acute inflammatory reactions , IL-1_alpha , TNF-alpha , IFN-gamma , and C5a utilizes LFA-1 , Mac-1 , and VLA-4 .
8006453	0	IL-1_alpha	45,55	TNF-alpha	89,98	IL-1 alpha	TNF-alpha	3552	7124	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Differential effects of interleukin_1-alpha -LRB- IL-1_alpha -RRB- or tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on motility of human melanoma cell lines on fibronectin .
8186322	0	IL-1_alpha	14,24	TNF-alpha	113,122	IL-1 alpha	TNF-alpha	3552	7124	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|dep|activation activation|nmod|gene gene|nmod|END_ENTITY	Regulation of IL-1_alpha expression in human keratinocytes : transcriptional activation of the IL-1_alpha gene by TNF-alpha , LPS , and IL-1_alpha .
8186322	0	IL-1_alpha	94,104	TNF-alpha	113,122	IL-1 alpha	TNF-alpha	3552	7124	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Regulation of IL-1_alpha expression in human keratinocytes : transcriptional activation of the IL-1_alpha gene by TNF-alpha , LPS , and IL-1_alpha .
8928088	0	IL-1_alpha	21,31	TNF-alpha	0,9	IL-1 alpha	TNF-alpha	3552	7124	Gene	Gene	upregulation|amod|START_ENTITY suppresses|dobj|upregulation suppresses|nsubj|END_ENTITY	TNF-alpha suppresses IL-1_alpha and IL-6 upregulation of C4b-binding_protein in HepG-2 hepatoma cells .
1940795	0	IL-1_alpha	161,171	epidermal_growth_factor	55,78	IL-1 alpha	epidermal growth factor	3552	1950	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Regulation of cytokine production in the human thymus : epidermal_growth_factor and transforming_growth_factor_alpha regulate mRNA levels of interleukin_1_alpha -LRB- IL-1_alpha -RRB- , IL-1_beta , and IL-6 in human thymic_epithelial cells at a post-transcriptional level .
18498295	0	IL-1_alpha	84,94	interleukin_1_alpha	63,82	IL-1 alpha	interleukin 1 alpha	3552	3552	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Complex effects of IL1A polymorphism and calpain inhibitors on interleukin_1_alpha -LRB- IL-1_alpha -RRB- mRNA levels and secretion of IL-1_alpha protein .
3265409	0	IL-1_alpha	59,69	interleukin_1_alpha	38,57	IL-1 alpha	interleukin 1 alpha	3552	3552	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal localization of the human interleukin_1_alpha -LRB- IL-1_alpha -RRB- gene .
2785566	0	IL-1_and_TNF	20,32	IL-4	0,4	IL-1 and TNF	IL-4	3553;7124	3565	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	IL-4 down-regulates IL-1_and_TNF gene expression in human monocytes .
7706741	0	IL-1_and_TNF	61,73	Phospholipase_A2-activating_protein	0,35	IL-1 and TNF	Phospholipase A2-activating protein	3553;7124	9373	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Phospholipase_A2-activating_protein induces the synthesis of IL-1_and_TNF in human monocytes .
8133053	0	IL-1_and_transforming_growth_factor-beta	0,40	IL-11	74,79	IL-1 and transforming growth factor-beta	IL-11	3553;7040	3589	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	IL-1_and_transforming_growth_factor-beta regulation of fibroblast-derived IL-11 .
2584706	0	IL-1_and_tumor_necrosis_factor	56,86	IL-6	16,20	IL-1 and tumor necrosis factor	IL-6	3552;7124	3569	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Contribution of IL-6 to the antiproliferative effect of IL-1_and_tumor_necrosis_factor on tumor cell lines .
8432990	0	IL-1_and_tumor_necrosis_factor-alpha	73,109	leukemia_inhibitory_factor	13,39	IL-1 and tumor necrosis factor-alpha	leukemia inhibitory factor	3552;7124	3976	Gene	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|nsubj|Induction Induction|nmod|END_ENTITY	Induction of leukemia_inhibitory_factor in human synovial fibroblasts by IL-1_and_tumor_necrosis_factor-alpha .
7981153	0	IL-1_and_tumor_necrosis_factor_receptor	47,86	Acid_sphingomyelinase	0,21	IL-1 and tumor necrosis factor receptor	Acid sphingomyelinase	3552	6609	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Acid_sphingomyelinase is not essential for the IL-1_and_tumor_necrosis_factor_receptor signaling pathway leading to NFkB activation .
22249478	0	IL-1_b	81,87	HIF-1a	43,49	IL-1 b	HIF-1a	3553	3091	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
22249478	0	IL-1_b	81,87	IGF-II	136,142	IL-1 b	IGF-II	3553	3481	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
24385987	0	IL-1_b	84,90	THP-1	105,110	IL-1 b	THP-1	3553	2736	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Coculture with Late , but Not Early , Human Endothelial Progenitor Cells Up Regulates IL-1_b Expression in THP-1 Monocytic Cells in a Paracrine Manner .
24999366	0	IL-1_b	40,46	THP-1	80,85	IL-1 b	THP-1	3553	2736	Gene	Gene	Decoction|nmod|START_ENTITY Effects|nmod|Decoction Effects|nmod|Cells Cells|compound|END_ENTITY	Effects of Modified Simiao Decoction on IL-1_b and TNF_a Secretion in Monocytic THP-1 Cells with Monosodium_Urate Crystals-Induced Inflammation .
22249478	0	IL-1_b	81,87	hypoxia-inducible_factor-1a	14,41	IL-1 b	hypoxia-inducible factor-1a	3553	3091	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
7695605	0	IL-1_beta	38,47	APP	23,26	IL-1 beta	APP	24494(Tax:10116)	54226(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Enhanced processing of APP induced by IL-1_beta can be reduced by indomethacin and nordihydroguaiaretic_acid .
8092265	0	IL-1_beta	0,9	COX_II	21,27	IL-1 beta	COX II	24494(Tax:10116)	26198(Tax:10116)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|compound|END_ENTITY	IL-1_beta stabilizes COX_II mRNA in renal mesangial cells : role of 3 ' - untranslated region .
9252556	0	IL-1_beta	0,9	ET-1	19,23	IL-1 beta	ET-1	24494(Tax:10116)	24323(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	IL-1_beta inhibits ET-1 production by ATII cells in vitro : evidence for involvement of cyclooxygenase_2 pathway .
7692628	0	IL-1_beta	18,27	G.CSF	11,16	IL-1 beta	G.CSF	3553	1440	Gene	Gene	HILDA/LIF|amod|START_ENTITY HILDA/LIF|amod|END_ENTITY	HILDA/LIF , G.CSF , IL-1_beta , IL-6 , and TNF_alpha production during acute rejection of human kidney allografts .
10857757	0	IL-1_beta	91,100	GM-CSF	120,126	IL-1 beta	GM-CSF	3553	1437	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The role of protein_kinase_C and calcium in induction of human polymorphonuclear leukocyte IL-1_beta gene expression by GM-CSF .
1536949	0	IL-1_beta	20,29	GM-CSF	161,167	IL-1 beta	GM-CSF	3553	1437	Gene	Gene	expression|appos|START_ENTITY regulated|nsubjpass|expression regulated|nmod|granulocyte-macrophage_colony-stimulating_factor granulocyte-macrophage_colony-stimulating_factor|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , M-CSF , and IL-3 .
22521737	0	IL-1_beta	24,33	G_protein-coupled_receptor_30	106,135	IL-1 beta	G protein-coupled receptor 30	3553	2852	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Genistein regulates the IL-1_beta induced activation of MAPKs in human periodontal ligament cells through G_protein-coupled_receptor_30 .
8666424	0	IL-1_beta	49,58	IFN-gamma	27,36	IL-1 beta	IFN-gamma	3553	3458	Gene	Gene	IL-4|dep|START_ENTITY END_ENTITY|dep|IL-4	Effect of human cytokines -LRB- IFN-gamma , TNF-alpha , IL-1_beta , IL-4 -RRB- on porcine endothelial cells : induction of MHC and adhesion molecules and functional significance of these changes .
9191887	0	IL-1_beta	138,147	IL-10	155,160	IL-1 beta	IL-10	3553	3586	Gene	Gene	TNF-beta|compound|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
11380940	0	IL-1_beta	132,141	IL-1Ra	92,98	IL-1 beta	IL-1Ra	3553	3557	Gene	Gene	polymorphisms|amod|START_ENTITY definition|nmod|polymorphisms polymorphisms|dep|definition polymorphisms|nmod|intron intron|nmod|gene gene|appos|END_ENTITY	Single nucleotide polymorphisms in intron 2 of the human interleukin-1_receptor_antagonist -LRB- IL-1Ra -RRB- gene : further definition of the IL-1_beta and IL-1Ra polymorphisms in North American Caucasians and Taiwanese Chinese .
7586694	0	IL-1_beta	24,33	IL-1Ra	64,70	IL-1 beta	IL-1Ra	3553	3557	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Allelic polymorphism in IL-1_beta and IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- genes in inflammatory_bowel_disease .
1316934	0	IL-1_beta	36,45	IL-1_alpha	50,60	IL-1 beta	IL-1 alpha	16176(Tax:10090)	16175(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Transition from interleukin_1_beta -LRB- IL-1_beta -RRB- to IL-1_alpha production during maturation of inflammatory macrophages in vivo .
2062178	0	IL-1_beta	18,27	IL-1_alpha	66,76	IL-1 beta	IL-1 alpha	3553	3552	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|production production|nmod|END_ENTITY	Recombinant human IL-1_beta and TNF-alpha stimulate production of IL-1_alpha and IL-1_beta by vascular smooth muscle cells and IL-1_alpha by vascular endothelial cells .
2787349	0	IL-1_beta	125,134	IL-1_alpha	97,107	IL-1 beta	IL-1 alpha	3553	3552	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Activation of normal human B cells through their antigen receptor induces membrane expression of IL-1_alpha and secretion of IL-1_beta .
3264804	0	IL-1_beta	107,116	IL-1_alpha	18,28	IL-1 beta	IL-1 alpha	3553	3552	Gene	Gene	form|nmod|START_ENTITY Existence|dep|form Existence|nmod|END_ENTITY	Existence of both IL-1_alpha and beta in normal human amniotic_fluid : unique high molecular weight form of IL-1_beta .
8964658	0	IL-1_beta	33,42	IL-1_alpha	86,96	IL-1 beta	IL-1 alpha	3553	3552	Gene	Gene	START_ENTITY|acl|converting converting|nmod|production production|amod|END_ENTITY	Effect of peptide aldehydes with IL-1_beta converting enzyme inhibitory properties on IL-1_alpha and IL-1_beta production in vitro .
9029492	0	IL-1_beta	0,9	IL-1_alpha	44,54	IL-1 beta	IL-1 alpha	24494(Tax:10116)	24493(Tax:10116)	Gene	Gene	transduces|nsubj|START_ENTITY transduces|nmod|END_ENTITY	IL-1_beta transduces different signals than IL-1_alpha leading to class II antigen expression on beta-insulinoma RIN-5AH cells through specific receptors .
9176529	0	IL-1_beta	37,46	IL-1_ra	77,84	IL-1 beta	IL-1 ra	3553	3557	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of inhaled glucocorticoids on IL-1_beta and IL-1_receptor_antagonist -LRB- IL-1_ra -RRB- expression in asthmatic bronchial epithelium .
8003022	0	IL-1_beta	58,67	IL-1_receptor_antagonist	73,97	IL-1 beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Signalling via MHC class II molecules selectively induces IL-1_beta over IL-1_receptor_antagonist gene expression .
18511291	0	IL-1_beta	39,48	IL-1ra	49,55	IL-1 beta	IL-1ra	3553	3557	Gene	Gene	disequilibrium|nmod|START_ENTITY Pro-inflammatory|dobj|disequilibrium ratio|dep|Pro-inflammatory ratio|compound|END_ENTITY	Pro-inflammatory disequilibrium of the IL-1_beta / IL-1ra ratio in an experimental model of perinatal brain_damages induced by lipopolysaccharide and hypoxia-ischemia .
7744786	1	IL-1_beta	176,185	IL-1ra	152,158	IL-1 beta	IL-1ra	3553	3557	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|site site|nmod|END_ENTITY	Identification of a single site in IL-1ra and two sites in IL-1_beta .
7881833	0	IL-1_beta	69,78	IL-1ra	36,42	IL-1 beta	IL-1ra	3553	3557	Gene	Gene	IL-1_receptor_antagonist|dep|START_ENTITY IL-1_receptor_antagonist|appos|END_ENTITY	Increased IL-1_receptor_antagonist -LRB- IL-1ra -RRB- production and decreased IL-1_beta / IL-1ra ratio in mononuclear cells from rheumatoid_arthritis patients .
7881833	0	IL-1_beta	69,78	IL-1ra	79,85	IL-1 beta	IL-1ra	3553	3557	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Increased IL-1_receptor_antagonist -LRB- IL-1ra -RRB- production and decreased IL-1_beta / IL-1ra ratio in mononuclear cells from rheumatoid_arthritis patients .
8048540	0	IL-1_beta	36,45	IL-1ra	0,6	IL-1 beta	IL-1ra	3553	3554	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	IL-1ra suppresses endotoxin-induced IL-1_beta and TNF-alpha release from mononuclear phagocytes .
8277611	0	IL-1_beta	47,56	IL-1ra	87,93	IL-1 beta	IL-1ra	3553	3557	Gene	Gene	expression|nmod|START_ENTITY evaluation|nmod|expression evaluation|appos|END_ENTITY	-LSB- Quantitative evaluation of gene expression of IL-1_beta and IL-1_receptor_antagonist -LRB- IL-1ra -RRB- from alveolar_macrophages in idiopathic_pulmonary_fibrosis -LRB- IPF -RRB- and sarcoidosis -RSB- .
9292778	0	IL-1_beta	41,50	IL-1ra	89,95	IL-1 beta	IL-1ra	16176(Tax:10090)	16181(Tax:10090)	Gene	Gene	pattern|dep|START_ENTITY pattern|dep|END_ENTITY	Different pattern of interleukin-1_beta - -LRB- IL-1_beta -RRB- , interleukin-1_receptor_antagonist - -LRB- IL-1ra -RRB- and interleukin-1_receptor_type_I - -LRB- IL-1R_tI -RRB- mRNA-expression in single preimplantation mouse embryos at various developmental stages .
8562579	3	IL-1_beta	508,517	IL-2	519,523	IL-1 beta	IL-2	3553	3558	Gene	Gene	IL-2_receptor|compound|START_ENTITY IL-2_receptor|dep|END_ENTITY	In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls -LRB- tumor_necrosis_factor_alpha - TNF_alpha ; interleukins IL-1_beta , IL-2 , IL-6 , soluble IL-2_receptor -RRB- .
1698865	0	IL-1_beta	31,40	IL-4	0,4	IL-1 beta	IL-4	3553	3565	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	IL-4 acts synergistically with IL-1_beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular_cell_adhesion_molecule-1 .
2129394	0	IL-1_beta	55,64	IL-4	47,51	IL-1 beta	IL-4	3553	3565	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Cytokine gene expression in atopics : effect of IL-4 on IL-1_beta and IL-6 mRNA levels .
11243098	0	IL-1_beta	25,34	IL-6	36,40	IL-1 beta	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|mRNA mRNA|compound|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
1335554	0	IL-1_beta	121,130	IL-6	72,76	IL-1 beta	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY and|dep|interaction involved|parataxis|and involved|nmod|END_ENTITY	A central mechanism is involved in the secretion of ACTH in response to IL-6 in rats : comparison to and interaction with IL-1_beta .
1382099	0	IL-1_beta	125,134	IL-6	43,47	IL-1 beta	IL-6	3553	3569	Gene	Gene	factor-alpha|compound|START_ENTITY response|nmod|factor-alpha astrocytes|nmod|response Production|nmod|astrocytes Production|appos|END_ENTITY	Production of hemolymphopoietic cytokines -LRB- IL-6 , IL-8 , colony-stimulating factors -RRB- by normal human astrocytes in response to IL-1_beta and tumor necrosis factor-alpha .
14580374	0	IL-1_beta	0,9	IL-6	73,77	IL-1 beta	IL-6	3553	3569	Gene	Gene	inducer|nsubj|START_ENTITY inducer|nmod|apoptosis apoptosis|nmod|membranes membranes|nmod|END_ENTITY	IL-1_beta is a better inducer of apoptosis in human fetal membranes than IL-6 .
16002736	0	IL-1_beta	0,9	IL-6	18,22	IL-1 beta	IL-6	3553	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-1_beta induces IL-6 expression in human orbital fibroblasts : identification of an anatomic-site specific phenotypic attribute relevant to thyroid-associated_ophthalmopathy .
19444976	0	IL-1_beta	0,9	IL-6	11,15	IL-1 beta	IL-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	elevated|advmod|START_ENTITY elevated|nsubj|END_ENTITY	IL-1_beta , IL-6 , KC and MCP-1 are elevated in synovial fluid from haemophilic mice with experimentally induced haemarthrosis .
19580863	0	IL-1_beta	8,17	IL-6	45,49	IL-1 beta	IL-6	3553	3569	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|release release|compound|END_ENTITY	Role of IL-1_beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures .
2265245	0	IL-1_beta	20,29	IL-6	87,91	IL-1 beta	IL-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	Interleukin-1_beta|appos|START_ENTITY induces|nsubj|Interleukin-1_beta induces|parataxis|implication implication|nmod|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- induces thrombocytosis in mice : possible implication of IL-6 .
7506738	0	IL-1_beta	67,76	IL-6	49,53	IL-1 beta	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	factor-alpha|compound|START_ENTITY mediating|nmod|factor-alpha mediating|dobj|induction induction|compound|END_ENTITY	Signal transduction pathways mediating astrocyte IL-6 induction by IL-1_beta and tumor necrosis factor-alpha .
7692628	0	IL-1_beta	18,27	IL-6	29,33	IL-1 beta	IL-6	3553	3569	Gene	Gene	HILDA/LIF|amod|START_ENTITY HILDA/LIF|amod|END_ENTITY	HILDA/LIF , G.CSF , IL-1_beta , IL-6 , and TNF_alpha production during acute rejection of human kidney allografts .
7921752	0	IL-1_beta	34,43	IL-6	120,124	IL-1 beta	IL-6	3553	3569	Gene	Gene	IL-6|dep|START_ENTITY cytokines|appos|IL-6 cytokines|dep|correlation correlation|nmod|END_ENTITY	Serum cytokines -LRB- IL-6 , TNF-alpha , IL-1_beta and IFN-gamma -RRB- in ankylosing_spondylitis : a close correlation between serum IL-6 and disease activity and severity .
8041488	0	IL-1_beta	118,127	IL-6	15,19	IL-1 beta	IL-6	3553	3569	Gene	Gene	interleukin-1_beta|appos|START_ENTITY interactions|nmod|interleukin-1_beta production|dep|interactions production|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- production and cell growth of cultured human ameningiomas : - interactions with interleukin-1_beta -LRB- IL-1_beta -RRB- and interleukin-4 -LRB- IL-4 -RRB- in vitro .
8376550	0	IL-1_beta	101,110	IL-6	56,60	IL-1 beta	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	synergism|nmod|START_ENTITY peptide|dep|synergism peptide|dep|induce induce|dobj|secretion secretion|compound|END_ENTITY	Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes : synergism with IL-1_beta and TNF_alpha .
8562579	3	IL-1_beta	508,517	IL-6	525,529	IL-1 beta	IL-6	3553	3569	Gene	Gene	IL-2_receptor|compound|START_ENTITY IL-2_receptor|dep|END_ENTITY	In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls -LRB- tumor_necrosis_factor_alpha - TNF_alpha ; interleukins IL-1_beta , IL-2 , IL-6 , soluble IL-2_receptor -RRB- .
8780215	0	IL-1_beta	91,100	IL-6	15,19	IL-1 beta	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY secreted|nmod|injection secreted|nsubjpass|Interleukin-6 Interleukin-6|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- is secreted from the brain after intracerebroventricular injection of IL-1_beta in rats .
8805054	0	IL-1_beta	90,99	IL-6	23,27	IL-1 beta	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|nmod|cells cells|amod|END_ENTITY	Polarized secretion of IL-6 by IEC-6 intestinal epithelial cells : differential effects of IL-1_beta and TNF-alpha .
9032749	0	IL-1_beta	33,42	IL-6	44,48	IL-1 beta	IL-6	3553	3569	Gene	Gene	START_ENTITY|appos|TNF-alpha TNF-alpha|compound|END_ENTITY	Increase in cytokine production -LRB- IL-1_beta , IL-6 , TNF-alpha but not IFN-gamma , GM-CSF or LIF -RRB- by stimulated whole blood cells in postmenopausal_osteoporosis .
9149805	0	IL-1_beta	170,179	IL-6	206,210	IL-1 beta	IL-6	3553	3569	Gene	Gene	induction|nmod|START_ENTITY induction|advcl|END_ENTITY	Use of the acute phase serum_amyloid_A2 -LRB- SAA2 -RRB- gene promoter in the analysis of pro- and anti-inflammatory mediators : differential kinetics of SAA2 promoter induction by IL-1_beta and TNF-alpha compared to IL-6 .
9191887	0	IL-1_beta	138,147	IL-6	149,153	IL-1 beta	IL-6	3553	3569	Gene	Gene	TNF-beta|compound|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9202660	0	IL-1_beta	80,89	IL-6	0,4	IL-1 beta	IL-6	3553	3569	Gene	Gene	stimulation|nmod|START_ENTITY cells|nmod|stimulation production|nmod|cells production|compound|END_ENTITY	IL-6 production in human intestinal epithelial cells following stimulation with IL-1_beta is associated with activation of the transcription factor NF-kappa_B .
9289991	0	IL-1_beta	42,51	IL-6	53,57	IL-1 beta	IL-6	3553	3569	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	-LSB- Plasma contents of cytokines -LRB- TNF-alpha , IL-1_beta , IL-6 -RRB- and their clearance during continuous hemofiltration in patients with sepsis and multiple_organ_failure -RSB- .
9594206	0	IL-1_beta	13,22	IL-6	35,39	IL-1 beta	IL-6	3553	3569	Gene	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	The study of IL-1_beta , TNF-alpha , IL-6 gene expression and plasma levels on hemodialysis before and after dialyzer reuse .
1536949	0	IL-1_beta	20,29	Interleukin-1_beta	0,18	IL-1 beta	Interleukin-1 beta	3553	3553	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , M-CSF , and IL-3 .
1732310	0	IL-1_beta	20,29	Interleukin-1_beta	0,18	IL-1 beta	Interleukin-1 beta	3553	3553	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Interleukin-1_beta -LRB- IL-1_beta -RRB- levels in gingival crevicular fluid from adults with previous evidence of destructive_periodontitis .
8021507	0	IL-1_beta	21,30	NF-kappa_B	0,10	IL-1 beta	NF-kappa B	3553	4790	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	NF-kappa_B regulates IL-1_beta transcription through a consensus NF-kappa_B binding site and a nonconsensus CRE-like site .
17905568	0	IL-1_beta	80,89	P2X7_receptor	48,61	IL-1 beta	P2X7 receptor	16176(Tax:10090)	18439(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	In vitro and in vivo evidence for a role of the P2X7_receptor in the release of IL-1_beta in the murine brain .
1716887	0	IL-1_beta	15,24	PADGEM	98,104	IL-1 beta	PADGEM	3553	6403	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|dep|END_ENTITY	Enhancement by IL-1_beta and IFN-gamma of platelet activation : adhesion to leukocytes via GMP-140 / PADGEM protein -LRB- CD62 -RRB- .
19097143	0	IL-1_beta	0,9	PKC_alpha	88,97	IL-1 beta	PKC alpha	3553	5578	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	IL-1_beta induces urokinase-plasminogen activator expression and cell migration through PKC_alpha , JNK1/2 , and NF-kappaB in A549 cells .
1710753	0	IL-1_beta	52,61	THP-1	70,75	IL-1 beta	THP-1	3553	2736	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|cells cells|compound|END_ENTITY	Platelet-activating factor stimulates expression of IL-1_beta mRNA in THP-1 cells .
10540185	0	IL-1_beta	72,81	TNF-alpha	60,69	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	IL-2_receptor|amod|START_ENTITY levels|appos|IL-2_receptor levels|nmod|alpha alpha|appos|END_ENTITY	Perioperative serum levels of tumour-necrosis-factor alpha -LRB- TNF-alpha -RRB- , IL-1_beta , IL-6 , IL-10 and soluble IL-2_receptor in patients undergoing cardiac surgery with cardiopulmonary bypass without and with correction for haemodilution .
10810453	0	IL-1_beta	90,99	TNF-alpha	134,143	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	stability|nmod|START_ENTITY regulation|nmod|stability regulation|appos|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
1443236	0	IL-1_beta	56,65	TNF-alpha	22,31	IL-1 beta	TNF-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	fever|amod|START_ENTITY attenuates|dobj|fever attenuates|nsubj|injection injection|nmod|END_ENTITY	Systemic injection of TNF-alpha attenuates fever due to IL-1_beta and LPS in rats .
1633263	0	IL-1_beta	34,43	TNF-alpha	23,32	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	undergoing|nsubj|START_ENTITY undergoing|nmod|production production|nmod|END_ENTITY	In vitro production of TNF-alpha , IL-1_beta and IL-6 by mononuclear blood cells of patients with renal_cell_carcinoma undergoing rIL-2 treatment .
1768736	0	IL-1_beta	39,48	TNF-alpha	20,29	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	START_ENTITY|nsubj|release release|nmod|END_ENTITY	Enhanced release of TNF-alpha , but not IL-1_beta , from uremic blood after endotoxin stimulation .
17901573	0	IL-1_beta	118,127	TNF-alpha	107,116	IL-1 beta	TNF-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	IL-6|amod|START_ENTITY concentrations|amod|IL-6 concentrations|nmod|END_ENTITY	Influence of enalapril , quinapril and losartan on lipopolysaccharide -LRB- LPS -RRB- - induced serum concentrations of TNF-alpha , IL-1_beta , IL-6 in spontaneously hypertensive rats -LRB- SHR -RRB- .
7515924	1	IL-1_beta	214,223	TNF-alpha	158,167	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	expression|compound|START_ENTITY up-regulation|nmod|expression paralleled|nmod|up-regulation paralleled|nsubjpass|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of TNF-alpha and IL-6 is paralleled by an up-regulation of IL-1_beta and granulocyte_colony-stimulating_factor expression .
7608561	0	IL-1_beta	79,88	TNF-alpha	92,101	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	induction|nmod|START_ENTITY required|nmod|induction required|nmod|END_ENTITY	A cyclic_adenosine_3 ' ,5 ' - monophosphate signal is required for the induction of IL-1_beta by TNF-alpha in human monocytes .
7681094	0	IL-1_beta	48,57	TNF-alpha	29,38	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	production|dep|START_ENTITY production|amod|END_ENTITY	Inflammatory fluids regulate TNF-alpha , but not IL-1_beta , production by human peritoneal macrophages .
7921752	0	IL-1_beta	34,43	TNF-alpha	23,32	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Serum cytokines -LRB- IL-6 , TNF-alpha , IL-1_beta and IFN-gamma -RRB- in ankylosing_spondylitis : a close correlation between serum IL-6 and disease activity and severity .
7948748	0	IL-1_beta	62,71	TNF-alpha	0,9	IL-1 beta	TNF-alpha	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	islets|amod|START_ENTITY effects|nmod|islets potentiate|dobj|effects potentiate|nsubj|END_ENTITY	TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1_beta on mouse pancreatic islets mainly via generation of nitric_oxide .
8189655	0	IL-1_beta	58,67	TNF-alpha	124,133	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- Serum levels and gene expressions of interleukin-1_beta -LRB- IL-1_beta -RRB- , interleukin-6 -LRB- IL-6 -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human renal_cell_carcinomas -RSB- .
8260601	0	IL-1_beta	96,105	TNF-alpha	85,94	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	production|amod|START_ENTITY END_ENTITY|appos|production	Antilipid a monoclonal antibody HA-1A : immune complex clearance of endotoxin reduces TNF-alpha , IL-1_beta and IL-6 production .
8370177	0	IL-1_beta	15,24	TNF-alpha	65,74	IL-1 beta	TNF-alpha	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY necrosis|nsubj|Interaction necrosis|dobj|factor-alpha factor-alpha|appos|END_ENTITY	Interaction of IL-1_beta , IL-6 and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- in human T cells activated by murine antigens .
8455368	0	IL-1_beta	33,42	TNF-alpha	22,31	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	glomerulonephritis|nsubj|START_ENTITY glomerulonephritis|nmod|production production|nmod|END_ENTITY	In situ production of TNF-alpha , IL-1_beta and IL-2R in ANCA-positive glomerulonephritis .
8666424	0	IL-1_beta	49,58	TNF-alpha	38,47	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	IL-4|dep|START_ENTITY IL-4|compound|END_ENTITY	Effect of human cytokines -LRB- IFN-gamma , TNF-alpha , IL-1_beta , IL-4 -RRB- on porcine endothelial cells : induction of MHC and adhesion molecules and functional significance of these changes .
9191887	0	IL-1_beta	138,147	TNF-alpha	169,178	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	TNF-beta|compound|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9227316	0	IL-1_beta	94,103	TNF-alpha	83,92	IL-1 beta	TNF-alpha	3553	7124	Gene	Gene	IL-10|amod|START_ENTITY IL-10|amod|END_ENTITY	Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha , IL-1_beta IL-10 by human leucocytes .
10769674	0	IL-1_beta	11,20	TNF_alpha	0,9	IL-1 beta	TNF alpha	3553	7124	Gene	Gene	production|amod|START_ENTITY END_ENTITY|appos|production	TNF_alpha , IL-1_beta and IL-6 production by peripheral blood monocytes in patients with renal_cell_carcinoma .
11243098	0	IL-1_beta	25,34	TNF_alpha	14,23	IL-1 beta	TNF alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
11243098	0	IL-1_beta	25,34	TNF_alpha	58,67	IL-1 beta	TNF alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|release release|nmod|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
7531179	0	IL-1_beta	11,20	TNF_alpha	0,9	IL-1 beta	TNF alpha	3553	7124	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	TNF_alpha , IL-1_beta and IL-6 plasma levels in neutropenic patients after onset of fever and correlation with the C-reactive_protein -LRB- CRP -RRB- kinetic values .
8758268	0	IL-1_beta	24,33	TNF_alpha	13,22	IL-1 beta	TNF alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|role role|nmod|END_ENTITY	-LSB- The role of TNF_alpha , IL-1_beta and MIP-1_alpha in LPS-induced organ injury -RSB- .
10201981	0	IL-1_beta	53,62	TNF_receptor-associated_factor-2	0,32	IL-1 beta	TNF receptor-associated factor-2	3553	7186	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	TNF_receptor-associated_factor-2 is involved in both IL-1_beta and TNF-alpha signaling cascades leading to NF-kappa_B activation and IL-8 expression in human intestinal epithelial cells .
11040101	0	IL-1_beta	40,49	VEGF	13,17	IL-1 beta	VEGF	24494(Tax:10116)	83785(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Induction of VEGF gene transcription by IL-1_beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes .
15383601	0	IL-1_beta	112,121	alpha-smooth_muscle_actin	67,92	IL-1 beta	alpha-smooth muscle actin	24494(Tax:10116)	25365(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	CCAAT/enhancer-binding protein beta isoforms and the regulation of alpha-smooth_muscle_actin gene expression by IL-1_beta .
8747137	0	IL-1_beta	0,9	alpha_1-antichymotrypsin	46,70	IL-1 beta	alpha 1-antichymotrypsin	3553	12	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	IL-1_beta and TNF_alpha , but not IL-6 , induce alpha_1-antichymotrypsin expression in the human astrocytoma cell line U373 MG .
14695653	0	IL-1_beta	31,40	cPLA2	22,27	IL-1 beta	cPLA2	3553	5321	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	The mediating role of cPLA2 in IL-1_beta and IL-6 release in LPS-induced HeLa cells .
10810453	0	IL-1_beta	90,99	cyclooxygenase-2	27,43	IL-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	stability|nmod|START_ENTITY stability|amod|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
1353022	0	IL-1_beta	53,62	interleukin-1_beta	33,51	IL-1 beta	interleukin-1 beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A TaqI polymorphism in the human interleukin-1_beta -LRB- IL-1_beta -RRB- gene correlates with IL-1_beta secretion in vitro .
1387412	0	IL-1_beta	91,100	interleukin-1_beta	71,89	IL-1 beta	interleukin-1 beta	3553	3553	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Human dermal fibroblast interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- and interleukin-1_beta -LRB- IL-1_beta -RRB- mRNA and protein are co-stimulated by phorbol_ester : implication for a homeostatic mechanism .
1596574	0	IL-1_beta	78,87	interleukin-1_beta	58,76	IL-1 beta	interleukin-1 beta	3553	3553	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and interleukin-1_beta -LRB- IL-1_beta -RRB- messenger RNA -LRB- mRNA -RRB- expression in HL-60 leukemia cells by pentoxifylline and dexamethasone : dissociation of acivicin-induced TNF-alpha and IL-1_beta mRNA expression from acivicin-induced monocytoid differentiation .
7684503	0	IL-1_beta	38,47	interleukin-1_beta	18,36	IL-1 beta	interleukin-1 beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of the interleukin-1_beta -LRB- IL-1_beta -RRB- gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear_factor-IL6 motifs .
9187965	0	IL-1_beta	131,140	interleukin-1_beta	111,129	IL-1 beta	interleukin-1 beta	3553	3553	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differential effects of cell density on 5-lipoxygenase -LRB- 5-LO -RRB- , five-lipoxygenase-activating_protein -LRB- FLAP -RRB- and interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human neutrophils .
9292778	0	IL-1_beta	41,50	interleukin-1_beta	21,39	IL-1 beta	interleukin-1 beta	16176(Tax:10090)	16176(Tax:10090)	Gene	Gene	pattern|dep|START_ENTITY pattern|nmod|END_ENTITY	Different pattern of interleukin-1_beta - -LRB- IL-1_beta -RRB- , interleukin-1_receptor_antagonist - -LRB- IL-1ra -RRB- and interleukin-1_receptor_type_I - -LRB- IL-1R_tI -RRB- mRNA-expression in single preimplantation mouse embryos at various developmental stages .
7922784	0	IL-1_beta	24,33	interleukin-8	56,69	IL-1 beta	interleukin-8	3553	3576	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Dexamethasone regulates IL-1_beta and TNF-alpha-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells .
11288134	0	IL-1_beta	48,57	interleukin_1_beta	28,46	IL-1 beta	interleukin 1 beta	3553	3553	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Allergen-induced changes in interleukin_1_beta -LRB- IL-1_beta -RRB- mRNA expression by human blood-derived dendritic cells : inter-individual differences and relevance for sensitization testing .
14510824	0	IL-1_beta	62,71	interleukin_1_beta	42,60	IL-1 beta	interleukin 1 beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis of a polymorphism of interleukin_1_beta -LRB- IL-1_beta -RRB- gene with temporal_lobe_epilepsy in a Chinese population .
8760825	0	IL-1_beta	39,48	interleukin_1_beta	19,37	IL-1 beta	interleukin 1 beta	3553	3553	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Functional role of interleukin_1_beta -LRB- IL-1_beta -RRB- in IL-1_beta-converting enzyme-mediated apoptosis .
9458919	0	IL-1_beta	0,9	leptin	19,25	IL-1 beta	leptin	16176(Tax:10090)	16846(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|compound|END_ENTITY	IL-1_beta mediates leptin induction during inflammation .
9321960	0	IL-1_beta	63,72	lipocortin_1	30,42	IL-1 beta	lipocortin 1	3553	301	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The co-ordinate regulation of lipocortin_1 , COX_2 and cPLA2 by IL-1_beta in A549 cells .
12840897	0	IL-1_beta	10,19	monocyte_chemotactic_protein-1	55,85	IL-1 beta	monocyte chemotactic protein-1	3553	6347	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of IL-1_beta and TNF-alpha on the expression of monocyte_chemotactic_protein-1 in endometriotic cells .
7775337	0	IL-1_beta	88,97	neutral_endopeptidase	8,29	IL-1 beta	neutral endopeptidase	24494(Tax:10116)	24590(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of neutral_endopeptidase in bronchial_hyperresponsiveness to bradykinin induced by IL-1_beta .
11053030	0	IL-1_beta	25,34	p38_MAP_kinase	0,14	IL-1 beta	p38 MAP kinase	3553	1432	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	p38_MAP_kinase regulates IL-1_beta responses in cultured airway smooth muscle cells .
7546776	0	IL-1_beta	20,29	platelet-derived_growth_factor_alpha-receptor	94,139	IL-1 beta	platelet-derived growth factor alpha-receptor	24494(Tax:10116)	25267(Tax:10116)	Gene	Gene	upregulate|nsubj|START_ENTITY upregulate|dobj|END_ENTITY	Interleukin_1_beta -LRB- IL-1_beta -RRB- and the IL-1_beta-alpha_2-macroglobulin complex upregulate the platelet-derived_growth_factor_alpha-receptor on rat pulmonary fibroblasts .
1700994	0	IL-1_beta	11,20	thioredoxin	60,71	IL-1 beta	thioredoxin	3553	7295	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of IL-1_beta to alpha-macroglobulins and release by thioredoxin .
8496597	0	IL-1_beta	109,118	tumor_necrosis_factor-alpha	80,107	IL-1 beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Differential action of cycloheximide and activation stimuli on transcription of tumor_necrosis_factor-alpha , IL-1_beta , IL-8 , and P53 genes in human monocytes .
9435641	0	IL-1_beta	39,48	tumor_necrosis_factor-alpha	70,97	IL-1 beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	production|compound|START_ENTITY production|dep|roles roles|nmod|END_ENTITY	Epinephrine inhibits endotoxin-induced IL-1_beta production : roles of tumor_necrosis_factor-alpha and IL-10 .
8159270	0	IL-1_beta	0,9	vasopressin	59,70	IL-1 beta	vasopressin	3553	551	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|release release|nmod|END_ENTITY	IL-1_beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro , but not from the amygdala .
9525339	0	IL-1_or_TNF	29,40	IL-6	0,4	IL-1 or TNF	IL-6	3552;7124	3569	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	IL-6 mediates the effects of IL-1_or_TNF , but not PTHrP or 1,25 -LRB- OH -RRB- 2D3 , on osteoclast-like cell formation in normal human bone_marrow_cultures .
9176529	0	IL-1_ra	77,84	IL-1_beta	37,46	IL-1 ra	IL-1 beta	3557	3553	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of inhaled glucocorticoids on IL-1_beta and IL-1_receptor_antagonist -LRB- IL-1_ra -RRB- expression in asthmatic bronchial epithelium .
21690387	0	IL-1_receptor-associated_kinase-M	8,41	IRAK-M	43,49	IL-1 receptor-associated kinase-M	IRAK-M	73914(Tax:10090)	73914(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of IL-1_receptor-associated_kinase-M -LRB- IRAK-M -RRB- in priming of immune and inflammatory responses by nitrogen bisphosphonates .
18156187	0	IL-1_receptor-associated_kinase-M	36,69	THP-1	73,78	IL-1 receptor-associated kinase-M	THP-1	11213	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Early and preferential induction of IL-1_receptor-associated_kinase-M in THP-1 cells by LPS derived from Porphyromonas_gingivalis .
18450470	0	IL-1_receptor_accessory_protein	4,35	IL-33	58,63	IL-1 receptor accessory protein	IL-33	16180(Tax:10090)	77125(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|signaling signaling|compound|END_ENTITY	The IL-1_receptor_accessory_protein -LRB- AcP -RRB- is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 .
9346915	0	IL-1_receptor_accessory_protein	73,104	acid_sphingomyelinase	14,35	IL-1 receptor accessory protein	acid sphingomyelinase	3556	6609	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of acid_sphingomyelinase by interleukin-1 _ -LRB- IL-1 -RRB- requires the IL-1_receptor_accessory_protein .
9710237	0	IL-1_receptor_antagonist	0,24	IL-1Ra	26,32	IL-1 receptor antagonist	IL-1Ra	3557	3557	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes .
8003022	0	IL-1_receptor_antagonist	73,97	IL-1_beta	58,67	IL-1 receptor antagonist	IL-1 beta	3557	3553	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Signalling via MHC class II molecules selectively induces IL-1_beta over IL-1_receptor_antagonist gene expression .
12355453	0	IL-1_receptor_antagonist	79,103	IL-1beta	19,27	IL-1 receptor antagonist	IL-1beta	3557	3553	Gene	Gene	regulation|nmod|START_ENTITY bioactivity|nmod|regulation bioactivity|nsubj|control control|nmod|END_ENTITY	Genetic control of IL-1beta bioactivity through differential regulation of the IL-1_receptor_antagonist .
15141093	0	IL-1_receptor_antagonist	41,65	IL-1beta	81,89	IL-1 receptor antagonist	IL-1beta	3557	3553	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Leptin modulates beta cell expression of IL-1_receptor_antagonist and release of IL-1beta in human islets .
16553947	0	IL-1_receptor_antagonist	137,161	IL-1beta	128,136	IL-1 receptor antagonist	IL-1beta	3557	3553	Gene	Gene	DNA|parataxis|START_ENTITY DNA|dep|leading leading|nmod|shift shift|nmod|END_ENTITY	Beta - -LRB- 1 -- > 3 -RRB- - D-glucan modulates DNA binding of nuclear factors kappaB , AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta / IL-1_receptor_antagonist ratio .
17182583	0	IL-1_receptor_antagonist	45,69	IL-1beta	23,31	IL-1 receptor antagonist	IL-1beta	3557	3553	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Opposite regulation of IL-1beta and secreted IL-1_receptor_antagonist production by phosphatidylinositide-3 kinases in human monocytes activated by lipopolysaccharides or contact with T cells .
19255448	0	IL-1_receptor_antagonist	29,53	IL-1beta	83,91	IL-1 receptor antagonist	IL-1beta	3557	3553	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Glatiramer_acetate increases IL-1_receptor_antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple_sclerosis .
9112403	0	IL-1_receptor_antagonist	97,121	IL-1beta	34,42	IL-1 receptor antagonist	IL-1beta	3557	3553	Gene	Gene	counteracted|nmod|START_ENTITY counteracted|nsubjpass|effects effects|nmod|END_ENTITY	The effects of interleukin-1beta -LRB- IL-1beta -RRB- on human thyrocyte functions are counteracted by the IL-1_receptor_antagonist .
9565638	0	IL-1_receptor_antagonist	97,121	IL-1beta	133,141	IL-1 receptor antagonist	IL-1beta	16181(Tax:10090)	16176(Tax:10090)	Gene	Gene	shows|nsubj|START_ENTITY shows|ccomp|crucial crucial|nsubj|END_ENTITY	Production of mice deficient in genes for interleukin _ -LRB- IL -RRB- -1 alpha , IL-1beta , IL-1alpha / beta , and IL-1_receptor_antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion .
9949173	0	IL-1_receptor_antagonist	79,103	IL-1beta	53,61	IL-1 receptor antagonist	IL-1beta	3557	3553	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells END_ENTITY|nmod|production	Interleukin-4 -LRB- IL-4 -RRB- and IL-13 enhance the effect of IL-1beta on production of IL-1_receptor_antagonist by human primary hepatocytes and hepatoma HepG2 cells : differential effect on C-reactive_protein production .
8786311	0	IL-1_receptor_antagonist	0,24	IL-1ra	26,32	IL-1 receptor antagonist	IL-1ra	16181(Tax:10090)	16181(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	IL-1_receptor_antagonist -LRB- IL-1ra -RRB- expression , function , and cytokine-mediated regulation during mycobacterial and schistosomal antigen-elicited granuloma formation .
1386096	0	IL-1_receptor_antagonist	18,42	IL-4	0,4	IL-1 receptor antagonist	IL-4	3557	3565	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-4 up-regulates IL-1_receptor_antagonist gene expression and its production in human blood monocytes .
15365221	0	IL-1_receptor_antagonist	40,64	IL1RN	71,76	IL-1 receptor antagonist	IL1RN	3557	3557	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Replication test for association of the IL-1_receptor_antagonist gene , IL1RN , with attention-deficit/hyperactivity _ disorder .
8605347	0	IL-1_receptor_antagonist	31,55	Interleukin-13	0,14	IL-1 receptor antagonist	Interleukin-13	3557	3596	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-13 -LRB- IL-13 -RRB- induces IL-1_receptor_antagonist gene expression and protein synthesis in peripheral blood mononuclear cells : inhibition by an IL-4 mutant protein .
15141093	0	IL-1_receptor_antagonist	41,65	Leptin	0,6	IL-1 receptor antagonist	Leptin	3557	3952	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Leptin modulates beta cell expression of IL-1_receptor_antagonist and release of IL-1beta in human islets .
22967398	0	IL-1_receptor_antagonist	24,48	Matrilin-3	0,10	IL-1 receptor antagonist	Matrilin-3	3557	4148	Gene	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	Matrilin-3 Induction of IL-1_receptor_antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression .
1292638	0	IL-1_receptor_antagonist	84,108	SAA	28,31	IL-1 receptor antagonist	SAA	16181(Tax:10090)	111345(Tax:10090)	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1_receptor_antagonist .
8023931	0	IL-1_receptor_antagonist	10,34	TNF-alpha	52,61	IL-1 receptor antagonist	TNF-alpha	60582(Tax:10116)	24835(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IL-1_receptor_antagonist and antiserum to TNF-alpha on LPS-induced plasma ACTH and corticosterone rise in rats .
8435447	0	IL-1_receptor_antagonist	17,41	TNF-alpha	114,123	IL-1 receptor antagonist	TNF-alpha	3557	7124	Gene	Gene	synthesis|nmod|START_ENTITY increased|nsubj|synthesis increased|nmod|END_ENTITY	The synthesis of IL-1_receptor_antagonist -LRB- IL-1ra -RRB- by synovial fibroblasts is markedly increased by the cytokines TNF-alpha and IL-1 .
8809146	0	IL-1_receptor_antagonist	62,86	TNF-alpha	167,176	IL-1 receptor antagonist	TNF-alpha	3557	7124	Gene	Gene	induction|nmod|START_ENTITY properties|dep|induction properties|dep|down-regulation down-regulation|nmod|factor-alpha factor-alpha|appos|END_ENTITY	Anti-inflammatory properties of human serum IgA : induction of IL-1_receptor_antagonist and Fc_alpha_R -LRB- CD89 -RRB- - mediated down-regulation of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and IL-6 in human monocytes .
8468489	0	IL-1_receptor_antagonist	69,93	Transforming_growth_factor-beta	0,31	IL-1 receptor antagonist	Transforming growth factor-beta	3557	7040	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Transforming_growth_factor-beta mediates IL-1-dependent induction of IL-1_receptor_antagonist .
8548552	0	IL-1_receptor_antagonist	39,63	hIL-1ra	65,72	IL-1 receptor antagonist	hIL-1ra	3557	3557	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Prolonged systemic expression of human IL-1_receptor_antagonist -LRB- hIL-1ra -RRB- in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA .
9626334	0	IL-1_receptor_antagonist	72,96	interferon-gamma	14,30	IL-1 receptor antagonist	interferon-gamma	3557	3458	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Modulation by interferon-gamma of the production and gene expression of IL-1_receptor_antagonist in human neutrophils .
15728517	0	IL-1_receptor_associated_kinase-M	56,89	CD44	105,109	IL-1 receptor associated kinase-M	CD44	11213	960	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Tumor cells deactivate human monocytes by up-regulating IL-1_receptor_associated_kinase-M expression via CD44 and TLR4 .
26232334	0	IL-1a	47,52	ADAMTS-2	19,27	IL-1a	ADAMTS-2	3552	9509	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of human ADAMTS-2 gene expression by IL-1a is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cells .
26506473	0	IL-1a	81,86	AIM2	93,97	IL-1a	AIM2	3552	9447	Gene	Gene	START_ENTITY|nmod|Manner Manner|compound|END_ENTITY	Human Lung Cancer-Derived Immunosuppressive Plasmacytoid Dendritic Cells Release IL-1a in an AIM2 Inflammasome-Dependent Manner .
25237386	0	IL-1a	41,46	AKT	105,108	IL-1a	AKT	3552	207	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Seminal plasma induces the expression of IL-1a in normal and neoplastic cervical cells via EP2/EGFR/PI3K / AKT pathway .
22163019	0	IL-1a	0,5	IL-1R1	6,12	IL-1a	IL-1R1	16175(Tax:10090)	16177(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	IL-1a / IL-1R1 expression in chronic_obstructive_pulmonary_disease and mechanistic relevance to smoke-induced neutrophilia in mice .
21622588	0	IL-1a	8,13	IL-1b	38,43	IL-1a	IL-1b	16175(Tax:10090)	16176(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|axis axis|compound|END_ENTITY	Role of IL-1a and the Nlrp3/caspase -1 / IL-1b axis in cigarette smoke-induced pulmonary_inflammation and COPD .
24352037	0	IL-1a	100,105	IL-6	106,110	IL-1a	IL-6	3552	3569	Gene	Gene	loop|amod|START_ENTITY loop|compound|END_ENTITY	Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1a / IL-6 loop .
22339577	0	IL-1a	60,65	elastin	31,38	IL-1a	elastin	3552	2006	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Coenzyme Q -LRB- 10 -RRB- enhances dermal elastin expression , inhibits IL-1a production and melanin synthesis in vitro .
21041994	0	IL-1a	56,61	proteoglycan-4	27,41	IL-1a	proteoglycan-4	24493(Tax:10116)	289104(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of proteoglycan-4 expression by IL-1a and TGF-b1 in rat condylar chondrocytes .
24400695	0	IL-1a	0,5	skeletal_muscle_ryanodine_receptor	26,60	IL-1a	skeletal muscle ryanodine receptor	3552	6261	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IL-1a reversibly inhibits skeletal_muscle_ryanodine_receptor .
11745457	0	IL-1alpha	149,158	Gro_1	38,43	IL-1alpha	Gro 1	16175(Tax:10090)	14825(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of proangiogenic chemokine Gro_1 in low and high metastatic variants of Pam murine squamous_cell_carcinoma is differentially regulated by IL-1alpha , EGF and TGF-beta1 through NF-kappaB dependent and independent mechanisms .
9495511	0	IL-1alpha	0,9	IL-1beta	11,19	IL-1alpha	IL-1beta	16175(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-6|amod|START_ENTITY IL-6|dep|END_ENTITY	IL-1alpha , IL-1beta , IL-6 , and TNF-alpha steady-state mRNA levels analyzed by reverse transcription-competitive PCR in bone marrow of gonadectomized mice .
14655147	0	IL-1alpha	32,41	IL-2	43,47	IL-1alpha	IL-2	3552	3558	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Tissue expression of cytokines -LRB- IL-1alpha , IL-2 , IL-6 , IL-12 , TNF-alpha -RRB- in B-cell_lymphomas in children .
9776110	0	IL-1alpha	38,47	IL-2	75,79	IL-1alpha	IL-2	3552	3558	Gene	Gene	TNF-alpha|dep|START_ENTITY pro-inflammatory|appos|TNF-alpha pro-inflammatory|appos|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
9776110	0	IL-1alpha	38,47	IL-4	81,85	IL-1alpha	IL-4	3552	3565	Gene	Gene	TNF-alpha|dep|START_ENTITY pro-inflammatory|appos|TNF-alpha pro-inflammatory|appos|IL-2 IL-2|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
10225968	0	IL-1alpha	11,20	IL-6	65,69	IL-1alpha	IL-6	3552	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Endogenous IL-1alpha from systemic_sclerosis fibroblasts induces IL-6 and PDGF-A .
19805069	0	IL-1alpha	19,28	IL-6	83,87	IL-1alpha	IL-6	3552	3569	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|network network|compound|END_ENTITY	Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6 / IL-8 cytokine network .
9776110	0	IL-1alpha	38,47	IL-6	49,53	IL-1alpha	IL-6	3552	3569	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
19805069	0	IL-1alpha	19,28	IL-8	88,92	IL-1alpha	IL-8	3552	3576	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|network network|compound|END_ENTITY	Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6 / IL-8 cytokine network .
14699442	0	IL-1alpha	20,29	Interleukin_1alpha	0,18	IL-1alpha	Interleukin 1alpha	16175(Tax:10090)	16175(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	Interleukin_1alpha -LRB- IL-1alpha -RRB- induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function .
14631115	0	IL-1alpha	28,37	MMP-9	51,56	IL-1alpha	MMP-9	3552	4318	Gene	Gene	induction|compound|START_ENTITY role|nmod|induction role|nmod|END_ENTITY	Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line .
9527395	0	IL-1alpha	22,31	RANTES	61,67	IL-1alpha	RANTES	3552	6352	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Synergistic effect of IL-1alpha , IFN-gamma , and TNF-alpha on RANTES production by human renal tubular epithelial cells in vitro .
12441141	0	IL-1alpha	16,25	TNF	36,39	IL-1alpha	TNF	24493(Tax:10116)	24835(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of IL-1alpha , IL-1 RI , TNF , TNF-RI and TNF-RII during physiological drift of rat molar teeth -- an immunohistochemical and in situ hybridization study .
11137138	0	IL-1alpha	73,82	TNF-alpha	84,93	IL-1alpha	TNF-alpha	3552	7124	Gene	Gene	phospholipase_A2|nmod|START_ENTITY effect|nmod|phospholipase_A2 level|nmod|effect level|nsubj|END_ENTITY	In vivo effect of snake phospholipase_A2 -LRB- crotoxin + cardiotoxin -RRB- on serum IL-1alpha , TNF-alpha and IL-1ra level in humans .
14655147	0	IL-1alpha	32,41	TNF-alpha	62,71	IL-1alpha	TNF-alpha	3552	7124	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Tissue expression of cytokines -LRB- IL-1alpha , IL-2 , IL-6 , IL-12 , TNF-alpha -RRB- in B-cell_lymphomas in children .
8907203	0	IL-1alpha	28,37	TNF-alpha	17,26	IL-1alpha	TNF-alpha	3552	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Cytokines -LRB- IL-6 , TNF-alpha , IL-1alpha -RRB- and soluble interleukin-2 receptor as serum tumor markers in multiple_myeloma .
15381721	0	IL-1alpha	0,9	cathepsin_K	21,32	IL-1alpha	cathepsin K	3552	1513	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	IL-1alpha stimulates cathepsin_K expression in osteoclasts via the tyrosine kinase-NF-kappaB pathway .
12453471	0	IL-1alpha	79,88	interleukin_1_alpha	58,77	IL-1alpha	interleukin 1 alpha	3552	3552	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel regulatory element in the human interleukin_1_alpha -LRB- IL-1alpha -RRB- gene promoter .
10843761	0	IL-1alpha	149,158	oncostatin_M	116,128	IL-1alpha	oncostatin M	281250(Tax:9913)	319086(Tax:9913)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Transforming_growth_factor_beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin_M in combination with IL-1alpha .
14631115	0	IL-1alpha	28,37	p38	21,24	IL-1alpha	p38	3552	1432	Gene	Gene	induction|compound|START_ENTITY role|nmod|induction role|nmod|END_ENTITY	Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line .
21732076	0	IL-1b	0,5	ADAMTS-13	21,30	IL-1b	ADAMTS-13	3553	11093	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	IL-1b down-regulates ADAMTS-13 mRNA expression in cells of the central nervous system .
27067395	0	IL-1b	4,9	ADAMTS-5	23,31	IL-1b	ADAMTS-5	3553	11096	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	The IL-1b / AP-1 / miR-30a / ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis .
23175174	0	IL-1b	43,48	ADAMTS9	16,23	IL-1b	ADAMTS9	3553	56999	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Augmentation of ADAMTS9 gene expression by IL-1b is reversed by NFkB and MAPK inhibitors , but not PI3 kinase inhibitors .
24563688	0	IL-1b	49,54	Angiopoietin-1	0,14	IL-1b	Angiopoietin-1	3553	284	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Angiopoietin-1 upregulates de novo expression of IL-1b and Il1-Ra , and the exclusive release of Il1-Ra from human neutrophils .
23351078	0	IL-1b	23,28	B1_and_B2	53,62	IL-1b	B1 and B2	3553	931	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	IL-4 and IL-13 inhibit IL-1b and TNF-a induced kinin B1_and_B2 receptors through a STAT6-dependent mechanism .
25556565	0	IL-1b	114,119	C-Type_Natriuretic_Peptide	22,48	IL-1b	C-Type Natriuretic Peptide	3553	4880	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Controlled Release of C-Type_Natriuretic_Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1b in Cartilage Explants .
22260630	0	IL-1b	61,66	C/EBPb	125,131	IL-1b	C/EBPb	3553	1051	Gene	Gene	synthase-1|nmod|START_ENTITY prostaglandin_E|amod|synthase-1 Regulation|nmod|prostaglandin_E requires|nsubj|Regulation requires|nmod|role role|nmod|END_ENTITY	Regulation of human microsomal prostaglandin_E synthase-1 by IL-1b requires a distal enhancer element with a unique role for C/EBPb .
25329476	0	IL-1b	29,34	C/EBPb	49,55	IL-1b	C/EBPb	3553	1051	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Allele-Specific Induction of IL-1b Expression by C/EBPb and PU .1 Contributes to Increased Tuberculosis Susceptibility .
21598302	0	IL-1b	112,117	C3a	11,14	IL-1b	C3a	3553	718	Gene	Gene	modulate|nmod|START_ENTITY modulate|nsubj|END_ENTITY	Complement C3a and C5a modulate osteoclast formation and inflammatory_response_of_osteoblasts in synergism with IL-1b .
24890729	0	IL-1b	0,5	CCR6	59,63	IL-1b	CCR6	3553	1235	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	IL-1b promotes the differentiation of polyfunctional human CCR6 + CXCR3 + Th1/17 cells that are specific for pathogenic and commensal microbes .
22496641	0	IL-1b	29,34	CEACAM1	0,7	IL-1b	CEACAM1	3553	634	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	CEACAM1 negatively regulates IL-1b production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex .
21310944	0	IL-1b	68,73	COX-2	19,24	IL-1b	COX-2	3553	5743	Gene	Gene	autoamplification|compound|START_ENTITY role|nmod|autoamplification expression|dep|role expression|compound|END_ENTITY	Macrophages induce COX-2 expression in breast_cancer cells : role of IL-1b autoamplification .
21394197	0	IL-1b	0,5	COX-2	17,22	IL-1b	COX-2	24494(Tax:10116)	26198(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|amod|dependent dependent|amod|END_ENTITY	IL-1b stimulates COX-2 dependent PGE synthesis and CGRP release in rat trigeminal ganglia cells .
23781123	0	IL-1b	174,179	COX-2	167,172	IL-1b	COX-2	16176(Tax:10090)	17709(Tax:10090)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Biphasic modulation of NOS expression , protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock : downstream regulation of COX-2 , IL-1b , TNF-a , IL-6 , and HMGB1 expression .
23886206	0	IL-1b	103,108	COX-2	96,101	IL-1b	COX-2	16176(Tax:10090)	17709(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24133591	0	IL-1b	65,70	COX-2	47,52	IL-1b	COX-2	3553	5743	Gene	Gene	signal|nmod|START_ENTITY signal|dobj|expression expression|nmod|END_ENTITY	MAPK/ERK signal pathway involved expression of COX-2 and VEGF by IL-1b induced in human endometriosis stromal cells in vitro .
25237168	0	IL-1b	128,133	COX-2	103,108	IL-1b	COX-2	3553	5743	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|dobj|prostaglandin_E2 prostaglandin_E2|nmod|production production|compound|END_ENTITY	Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin_E2 via COX-2 production without IL-1b and TNF-a .
25531650	0	IL-1b	31,36	COX-2	77,82	IL-1b	COX-2	24494(Tax:10116)	26198(Tax:10116)	Gene	Gene	RANK/RANKL|dep|START_ENTITY RANK/RANKL|nmod:npmod|END_ENTITY	Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
25806956	0	IL-1b	43,48	COX-2	89,94	IL-1b	COX-2	3553	4513	Gene	Gene	RANK/RANKL|compound|START_ENTITY RANK/RANKL|appos|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
26560040	0	IL-1b	66,71	COX-2	93,98	IL-1b	COX-2	3553	4513	Gene	Gene	levels|nmod|START_ENTITY E-prostanoid|dep|levels E-prostanoid|parataxis|IL-1_type_I_receptor IL-1_type_I_receptor|dep|pathway pathway|compound|END_ENTITY	Low E-prostanoid 2 receptor levels and deficient induction of the IL-1b / IL-1_type_I_receptor / COX-2 pathway : Vicious circle in patients with aspirin-exacerbated_respiratory_disease .
24890729	0	IL-1b	0,5	CXCR3	64,69	IL-1b	CXCR3	3553	2833	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	IL-1b promotes the differentiation of polyfunctional human CCR6 + CXCR3 + Th1/17 cells that are specific for pathogenic and commensal microbes .
20920345	0	IL-1b	100,105	Caspase-1	0,9	IL-1b	Caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	maturation|compound|START_ENTITY contributing|nmod|maturation involved|advcl|contributing involved|nsubjpass|END_ENTITY	Caspase-1 is involved in the genesis of inflammatory hypernociception by contributing to peripheral IL-1b maturation .
21731762	0	IL-1b	20,25	Caspase-1	0,9	IL-1b	Caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|dependent dependent|advmod|END_ENTITY	Caspase-1 dependent IL-1b secretion is critical for host defense in a mouse model of Chlamydia_pneumoniae lung infection .
26344742	0	IL-1b	20,25	Caspase-1	0,9	IL-1b	Caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
26344742	0	IL-1b	20,25	Caspase-1	0,9	IL-1b	Caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Caspase-1 Dependent IL-1b Secretion and Antigen-Specific T-Cell Activation by the Novel Adjuvant , PCEP .
27096899	0	IL-1b	52,57	Caspase-1	133,142	IL-1b	Caspase-1	3553	834	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|Requirements Requirements|nmod|END_ENTITY	Lipopolysaccharide-Mediated Induction of Concurrent IL-1b and IL-23 Expression in THP-1 Cells Exhibits Differential Requirements for Caspase-1 and Cathepsin_B Activity .
25451151	0	IL-1b	29,34	Caspase-8	16,25	IL-1b	Caspase-8	16176(Tax:10090)	12370(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Novel Roles for Caspase-8 in IL-1b and Inflammasome Regulation .
25294243	0	IL-1b	54,59	Cyclooxygenase-2	0,16	IL-1b	Cyclooxygenase-2	16176(Tax:10090)	19225(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY NLRP3|dep|Production NLRP3|compound|END_ENTITY	Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1b Production .
26514427	0	IL-1b	42,47	DCIR	0,4	IL-1b	DCIR	3553	50856	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	DCIR negatively regulates CpG-ODN-induced IL-1b and IL-6 production .
26065428	0	IL-1b	62,67	DNaseI	85,91	IL-1b	DNaseI	3553	13419(Tax:10090)	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|dobj|Translocation Translocation|compound|END_ENTITY	TNFa Amplifies DNaseI Expression in Renal Tubular Cells while IL-1b Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form .
26710124	0	IL-1b	78,83	Differentially_Expressed_in_Chondrocytes_2	0,42	IL-1b	Differentially Expressed in Chondrocytes 2	3553	79365	Gene	Gene	Expression|nmod|START_ENTITY Increases|dobj|Expression Increases|nsubj|END_ENTITY	Differentially_Expressed_in_Chondrocytes_2 -LRB- DEC2 -RRB- Increases the Expression of IL-1b and Is Abundantly Present in Synovial Membrane in Rheumatoid_Arthritis .
23171678	0	IL-1b	26,31	Follistatin	0,11	IL-1b	Follistatin	3553	10468	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Follistatin is induced by IL-1b and TNF-a in stromal cells from endometrioma .
20861081	0	IL-1b	35,40	Follistatin-like_1	0,18	IL-1b	Follistatin-like 1	16176(Tax:10090)	14314(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Follistatin-like_1 regulates renal IL-1b expression in cisplatin nephrotoxicity .
21779356	0	IL-1b	0,5	Foxp3	41,46	IL-1b	Foxp3	3553	50943	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	IL-1b promotes TGF-b1 and IL-2 dependent Foxp3 expression in regulatory T cells .
23928073	0	IL-1b	0,5	GFAP	14,18	IL-1b	GFAP	24494(Tax:10116)	24387(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-1b induces GFAP expression in vitro and in vivo and protects neurons from traumatic injury-associated apoptosis in rat brain striatum via NFkB/Ca - calmodulin/ERK mitogen-activated protein kinase signaling pathway .
23886206	0	IL-1b	103,108	GM-CSF	129,135	IL-1b	GM-CSF	16176(Tax:10090)	12981(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|acl|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
22707092	0	IL-1b	0,5	IFN-y	26,31	IL-1b	IFN-y	3553	3458	Gene	Gene	TNF-a|compound|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
22891275	0	IL-1b	0,5	IL-17A	80,86	IL-1b	IL-17A	3553	3605	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|promoting promoting|dobj|accumulation accumulation|nmod|END_ENTITY	IL-1b mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4 -LRB- + -RRB- Th17 cells .
25736459	0	IL-1b	95,100	IL-17A	101,107	IL-1b	IL-17A	16176(Tax:10090)	16171(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1b / IL-17A axis .
21622588	0	IL-1b	38,43	IL-1a	8,13	IL-1b	IL-1a	16176(Tax:10090)	16175(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY Role|dep|axis Role|nmod|END_ENTITY	Role of IL-1a and the Nlrp3/caspase -1 / IL-1b axis in cigarette smoke-induced pulmonary_inflammation and COPD .
24659294	0	IL-1b	48,53	IL-2	55,59	IL-1b	IL-2	3553	3558	Gene	Gene	IL-4|compound|START_ENTITY IL-4|dep|END_ENTITY	Effect of rotation and immobilization stress on IL-1b , IL-2 , IL-4 , and IFN-y production by splenocytes under opiate receptor blockade in vivo .
24996056	0	IL-1b	29,34	IL-32	0,5	IL-32	IL-32	9235	9235	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	IL-32 negatively regulates IL-1b production through its interaction with PKC and the inhibition of PU .1 phosphorylation .
19697035	0	IL-1b	23,28	IL-6	59,63	IL-1b	IL-6	3553	3569	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|nmod|END_ENTITY	Differential effect of IL-1b and TNFa on the production of IL-6 , IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages .
21300032	0	IL-1b	0,5	IL-6	26,30	IL-1b	IL-6	3553	3569	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|compound|END_ENTITY	IL-1b potently stabilizes IL-6 mRNA in human astrocytes .
21468727	0	IL-1b	54,59	IL-6	77,81	IL-1b	IL-6	3553	3569	Gene	Gene	response|nmod|START_ENTITY receptors|nmod|response expression|nmod|receptors produce|nsubj|expression produce|dobj|END_ENTITY	Increased expression of IL-1 receptors in response to IL-1b may produce more IL-6 , IL-8 , VEGF , and PGE in senescent synovial cells induced in vitro than in presenescent cells .
22079434	0	IL-1b	155,160	IL-6	117,121	IL-1b	IL-6	3553	3569	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Stimulation of inflammatory gene expression in human preadipocytes by macrophage-conditioned medium : upregulation of IL-6 production by macrophage-derived IL-1b .
22475267	0	IL-1b	27,32	IL-6	59,63	IL-1b	IL-6	3553	3569	Gene	Gene	Effects|nmod|START_ENTITY /|nsubj|Effects /|dobj|combinations combinations|appos|END_ENTITY	Effects of interleukin_1b -LRB- IL-1b -RRB- and IL-1b / interleukin_6 -LRB- IL-6 -RRB- combinations on drug metabolizing enzymes in human hepatocyte culture .
22508062	0	IL-1b	59,64	IL-6	0,4	IL-1b	IL-6	3553	3569	Gene	Gene	contribute|nsubj|START_ENTITY contribute|nsubj|production production|compound|END_ENTITY	IL-6 production stimulated by CD14 -LRB- + -RRB- monocytes-paracrined IL-1b does not contribute to the immunosuppressive activity of human umbilical cord mesenchymal stem cells .
22697788	0	IL-1b	62,67	IL-6	23,27	IL-1b	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY modulates|dobj|production modulates|nsubj|release release|nmod|END_ENTITY	LPS-induced release of IL-6 from glia modulates production of IL-1b in a JAK2-dependent manner .
22707092	0	IL-1b	0,5	IL-6	7,11	IL-1b	IL-6	3553	3569	Gene	Gene	TNF-a|compound|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
22919282	0	IL-1b	32,37	IL-6	39,43	IL-1b	IL-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY Constitutive|dobj|expression cause|ccomp|Constitutive cause|nsubj|END_ENTITY	Constitutive over expression of IL-1b , IL-6 , NF-kB , and Stat3 is a potential cause of lung_tumorgenesis in urethane -LRB- ethyl_carbamate -RRB- induced Balb/c mice .
23886206	0	IL-1b	103,108	IL-6	110,114	IL-1b	IL-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24455774	0	IL-1b	110,115	IL-6	22,26	IL-1b	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY induced|nmod|stimulation rats|acl|induced synoviocytes|nmod|rats suppresses|nmod|synoviocytes suppresses|dobj|production production|compound|END_ENTITY	Scopoletin suppresses IL-6 production from fibroblast-like synoviocytes of adjuvant_arthritis rats induced by IL-1b stimulation .
24965599	0	IL-1b	13,18	IL-6	67,71	IL-1b	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	Knockdown|nmod|START_ENTITY Improves|nsubj|Knockdown Improves|dobj|Associated Associated|nmod|Up-regulation Up-regulation|compound|END_ENTITY	Knockdown of IL-1b Improves Hypoxia-ischemia Brain Associated with IL-6 Up-regulation in Cell and Animal Models .
25239226	0	IL-1b	0,5	IL-6	14,18	IL-1b	IL-6	3553	3569	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	IL-1b Induces IL-6 production in retinal M ller cells predominantly through the activation of P38 MAPK/NF-kB signaling pathway .
25344820	0	IL-1b	92,97	IL-6	115,119	IL-1b	IL-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Upregulation Upregulation|compound|END_ENTITY	Age-Associated Increase in Cytokine Production During Systemic Inflammation-II : The Role of IL-1b in Age-Dependent IL-6 Upregulation in Adipose Tissue .
25982496	7	IL-1b	1082,1087	IL-6	1089,1093	TGF-b	IL-4	59086(Tax:10116)	287287(Tax:10116)	Gene	Gene	START_ENTITY|appos|CD40 CD40|compound|END_ENTITY	After LPS treatment , when compared with the KC single cultures , the expression of pro-inflammatory cytokines -LRB- IL-1b , IL-6 , MHC-II , CD40 , CD80 , and CD86 -RRB- in the coculture system was down-regulated , whereas the expression of anti-inflammatory cytokines -LRB- TGF-b , IL-4 , PGE2 , and IL-10 -RRB- was markedly increased .
25982496	7	IL-1b	1082,1087	IL-6	1089,1093	TGF-b	IL-4	59086(Tax:10116)	287287(Tax:10116)	Gene	Gene	START_ENTITY|appos|CD40 CD40|compound|END_ENTITY	After LPS treatment , when compared with the KC single cultures , the expression of pro-inflammatory cytokines -LRB- IL-1b , IL-6 , MHC-II , CD40 , CD80 , and CD86 -RRB- in the coculture system was down-regulated , whereas the expression of anti-inflammatory cytokines -LRB- TGF-b , IL-4 , PGE2 , and IL-10 -RRB- was markedly increased .
21475837	0	IL-1b	0,5	IL-8	17,21	IL-1b	IL-8	3553	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	IL-1b stimulates IL-8 production , including prostaglandin_E2 receptor EP4-triggered pathways , in synoviocyte MH7A cells .
22119045	0	IL-1b	100,105	IL-8	22,26	IL-1b	IL-8	3553	3576	Gene	Gene	stimulation|nmod|START_ENTITY cells|nmod|stimulation expression|nmod|cells expression|compound|END_ENTITY	Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1b or P. _ gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling .
22707092	0	IL-1b	0,5	IL-8	13,17	IL-1b	IL-8	3553	3576	Gene	Gene	TNF-a|compound|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
24706000	0	IL-1b	0,5	IL-8	18,22	IL-1b	IL-8	3553	3576	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	IL-1b Upregulates IL-8 Production in Human M ller Cells Through Activation of the p38 MAPK and ERK1/2 Signaling Pathways .
26817313	0	IL-1b	39,44	IL-8	46,50	IL-1b	IL-8	3553	3576	Gene	Gene	concentration|compound|START_ENTITY concentration|dep|END_ENTITY	-LSB- Evaluation of the correlation between IL-1b , IL-8 , IFN-y cytokine concentration in cervico-vaginal fluid and the risk of preterm_delivery -RSB- .
26848751	0	IL-1b	48,53	IL-8	62,66	IL-1b	IL-8	3553	3576	Gene	Gene	Epigallocatechin-3-Gallate|nmod|START_ENTITY -|dep|Epigallocatechin-3-Gallate Effect|nmod|- Induced|nsubj|Effect Induced|dobj|Expression Expression|compound|END_ENTITY	The Effect of -LRB- - -RRB- - Epigallocatechin-3-Gallate on IL-1b Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated_Ophthalmopathy .
25085021	0	IL-1b	24,29	IPAF	45,49	IL-1b	IPAF	16176(Tax:10090)	268973(Tax:10090)	Gene	Gene	release|compound|START_ENTITY release|nmod|pathway pathway|amod|END_ENTITY	TLR4 activation induces IL-1b release via an IPAF dependent but caspase_1 / 11/8 independent pathway in the lung .
26830368	0	IL-1b	24,29	Interleukin-17A	0,15	IL-1b	Interleukin-17A	3553	3605	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Interleukin-17A Induces IL-1b Secretion From RPE Cells Via the NLRP3 Inflammasome .
24993819	0	IL-1b	0,5	MCP-1	15,20	IL-1b	MCP-1	3553	6347	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|compound|END_ENTITY	IL-1b mediates MCP-1 induction by Wnt5a in gastric_cancer cells .
23454767	0	IL-1b	36,41	MFGE8	0,5	IL-1b	MFGE8	16176(Tax:10090)	17304(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	MFGE8 inhibits inflammasome-induced IL-1b production and limits postischemic_cerebral_injury .
23843954	0	IL-1b	20,25	MMP-2	46,51	IL-1b	MMP-2	24494(Tax:10116)	81686(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Carvedilol decrease IL-1b and TNF-a , inhibits MMP-2 , MMP-9 , COX-2 , and RANKL expression , and up-regulates OPG in a rat model of periodontitis .
25531650	0	IL-1b	31,36	MMP-2	63,68	IL-1b	MMP-2	24494(Tax:10116)	81686(Tax:10116)	Gene	Gene	RANK/RANKL|dep|START_ENTITY RANK/RANKL|nmod:npmod|END_ENTITY	Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
23328930	0	IL-1b	35,40	MMP-3	42,47	IL-1b	MMP-3	3553	4314	Gene	Gene	START_ENTITY|appos|production production|compound|END_ENTITY	Resveratrol inhibits TNF-a-induced IL-1b , MMP-3 production in human rheumatoid_arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway .
25531650	0	IL-1b	31,36	MMP-9	70,75	IL-1b	MMP-9	24494(Tax:10116)	81687(Tax:10116)	Gene	Gene	RANK/RANKL|dep|START_ENTITY RANK/RANKL|nmod:npmod|END_ENTITY	Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
25806956	0	IL-1b	43,48	MMP-9	82,87	IL-1b	MMP-9	3553	4318	Gene	Gene	RANK/RANKL|compound|START_ENTITY RANK/RANKL|appos|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
24487386	0	IL-1b	0,5	MUC5AC	19,25	IL-1b	MUC5AC	3553	4586	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	IL-1b induction of MUC5AC gene expression is mediated by CREB and NF-kB and repressed by dexamethasone .
20935193	0	IL-1b	15,20	MUC5B	41,46	IL-1b	MUC5B	3553	727897	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	NF-kB mediates IL-1b - and IL-17A-induced MUC5B expression in airway epithelial cells .
21403867	0	IL-1b	5,10	NGAL	30,34	IL-1b	NGAL	3553	3934	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Both IL-1b and TNF-a regulate NGAL expression in polymorphonuclear granulocytes of chronic hemodialysis patients .
20835230	0	IL-1b	100,105	NLRP3	18,23	IL-1b	NLRP3	3553	114548	Gene	Gene	mechanism|nmod|START_ENTITY provides|dobj|mechanism provides|nsubj|Activation Activation|nmod|inflammasome inflammasome|compound|END_ENTITY	Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes .
21239716	0	IL-1b	60,65	NLRP3	88,93	IL-1b	NLRP3	3553	114548	Gene	Gene	secretion|compound|START_ENTITY induce|dobj|secretion induce|nmod|inflammasome inflammasome|compound|END_ENTITY	Basic calcium_phosphate crystals induce monocyte/macrophage IL-1b secretion through the NLRP3 inflammasome in vitro .
21278344	0	IL-1b	72,77	NLRP3	106,111	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY trigger|dobj|secretion trigger|advcl|activating activating|dobj|inflammasome inflammasome|compound|END_ENTITY	Cutting edge : cyclic polypeptide and aminoglycoside antibiotics trigger IL-1b secretion by activating the NLRP3 inflammasome .
22488359	0	IL-1b	56,61	NLRP3	67,72	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	puzzle|nmod|START_ENTITY piece|nmod|puzzle piece|dep|inflammasome inflammasome|compound|END_ENTITY	An additional piece in the puzzle of neutrophil-derived IL-1b : the NLRP3 inflammasome .
22711073	0	IL-1b	59,64	NLRP3	8,13	IL-1b	NLRP3	3553	114548	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of NLRP3 and CARD8 in the regulation of TNF-a induced IL-1b release in vascular smooth muscle cells .
22926439	0	IL-1b	97,102	NLRP3	0,5	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY fibrils|nmod|source inflammasome|nmod|fibrils inflammasome|nsubj|END_ENTITY	NLRP3 inflammasome activation in macrophage cell lines by prion_protein fibrils as the source of IL-1b and neuronal_toxicity .
23209696	0	IL-1b	68,73	NLRP3	141,146	IL-1b	NLRP3	3553	114548	Gene	Gene	induced|xcomp|START_ENTITY enterohemolysin|acl|induced required|nsubj|enterohemolysin required|dobj|activation activation|nmod|inflammasome inflammasome|compound|END_ENTITY	Enterohemorrhagic Escherichia_coli specific enterohemolysin induced IL-1b in human macrophages and EHEC-induced IL-1b required activation of NLRP3 inflammasome .
23315075	0	IL-1b	37,42	NLRP3	89,94	IL-1b	NLRP3	3553	114548	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|advcl|activating activating|dobj|inflammasome inflammasome|compound|END_ENTITY	Self double-stranded -LRB- ds -RRB- DNA induces IL-1b production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies .
23633957	0	IL-1b	0,5	NLRP3	29,34	IL-1b	NLRP3	3553	114548	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	IL-1b production through the NLRP3 inflammasome by hepatic macrophages_links_hepatitis_C_virus_infection_with_liver_inflammation and disease .
23884315	0	IL-1b	32,37	NLRP3	56,61	IL-1b	NLRP3	3553	114548	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Propionibacterium_acnes Induces IL-1b secretion via the NLRP3 inflammasome in human monocytes .
24464629	0	IL-1b	13,18	NLRP3	48,53	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY induces|dobj|secretion induces|advcl|activating activating|dobj|END_ENTITY	Heme induces IL-1b secretion through activating NLRP3 in kidney_inflammation .
24470197	0	IL-1b	64,69	NLRP3	36,41	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nummod|END_ENTITY	Follistatin-like_protein_1 enhances NLRP3 inflammasome-mediated IL-1b secretion from monocytes and macrophages .
24692555	0	IL-1b	68,73	NLRP3	89,94	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	START_ENTITY|acl|activating activating|dobj|inflammasomes inflammasomes|nummod|END_ENTITY	RNA and b-hemolysin of group B Streptococcus induce interleukin-1b -LRB- IL-1b -RRB- by activating NLRP3 inflammasomes in mouse macrophages .
24894187	0	IL-1b	64,69	NLRP3	30,35	IL-1b	NLRP3	3553	114548	Gene	Gene	using|dobj|START_ENTITY activity|acl|using inflammasome|dobj|activity inflammasome|nsubj|Activation Activation|nmod|END_ENTITY	Activation and measurement of NLRP3 inflammasome activity using IL-1b in human monocyte-derived dendritic cells .
25231464	0	IL-1b	24,29	NLRP3	67,72	IL-1b	NLRP3	3553	114548	Gene	Gene	secretion|nsubj|START_ENTITY secretion|nmod|keratinocytes keratinocytes|nmod|Inflammasome Inflammasome|compound|END_ENTITY	Serum_amyloid_A Induces IL-1b secretion from keratinocytes via the NLRP3 Inflammasome .
25294243	0	IL-1b	54,59	NLRP3	27,32	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY END_ENTITY|dep|Production	Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1b Production .
25311115	0	IL-1b	72,77	NLRP3	9,14	IL-1b	NLRP3	3553	114548	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|activity activity|compound|END_ENTITY	Impaired NLRP3 inflammasome activity during fetal development regulates IL-1b production in human monocytes .
25386048	0	IL-1b	25,30	NLRP3	87,92	IL-1b	NLRP3	3553	114548	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nmod|pathways pathways|compound|END_ENTITY	Scropolioside B inhibits IL-1b and cytokines expression through NF-kB and inflammasome NLRP3 pathways .
25626736	0	IL-1b	94,99	NLRP3	66,71	IL-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Monounsaturated_Fatty_Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1b Secretion and Insulin Resistance Despite Obesity .
25834143	0	IL-1b	28,33	NLRP3	106,111	IL-1b	NLRP3	3553	114548	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nmod|activation activation|nmod|inflammasome inflammasome|nummod|END_ENTITY	Helicobacter_pylori induces IL-1b and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway .
25897296	0	IL-1b	59,64	NLRP3	12,17	IL-1b	NLRP3	3553	114548	Gene	Gene	release|nmod|START_ENTITY inflammasome|nmod|release inflammasome|nsubj|Role Role|nmod|END_ENTITY	Role of the NLRP3 inflammasome in the transient release of IL-1b induced by monosodium_urate crystals in human fibroblast-like synoviocytes .
26027935	0	IL-1b	53,58	NLRP3	26,31	IL-1b	NLRP3	3553	114548	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Diverse Activators of the NLRP3 Inflammasome Promote IL-1b Secretion by Triggering Necrosis .
26102024	0	IL-1b	32,37	NLRP3	82,87	IL-1b	NLRP3	3553	114548	Gene	Gene	release|compound|START_ENTITY induces|dobj|release induces|nmod|cells cells|nmod|activation activation|compound|END_ENTITY	Inhibition of autophagy induces IL-1b release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress .
26398903	0	IL-1b	167,172	NLRP3	139,144	IL-1b	NLRP3	3553	114548	Gene	Gene	Induction|compound|START_ENTITY Induction|compound|END_ENTITY	The Endoribonuclease Activity Essential for the Nonstructural Protein 11 of Porcine_Reproductive_and_Respiratory_Syndrome_Virus to Inhibit NLRP3 Inflammasome-Mediated IL-1b Induction .
26435646	0	IL-1b	51,56	NLRP3	22,27	IL-1b	NLRP3	3553	114548	Gene	Gene	secretion|compound|START_ENTITY secretion|nummod|END_ENTITY	Urate crystals induce NLRP3 inflammasome-dependent IL-1b secretion and proliferation in isolated primary human T-cells .
26616294	0	IL-1b	59,64	NLRP3	94,99	IL-1b	NLRP3	3553	114548	Gene	Gene	release|compound|START_ENTITY down-regulates|dobj|release down-regulates|advcl|inhibiting inhibiting|dobj|activation activation|dep|END_ENTITY	Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1b release by inhibiting NF-kB , NLRP3 inflammasome and caspase-1 activation in THP-1 cells .
26830368	0	IL-1b	24,29	NLRP3	63,68	IL-1b	NLRP3	3553	114548	Gene	Gene	Secretion|compound|START_ENTITY Via|nsubj|Secretion Via|dobj|Inflammasome Inflammasome|compound|END_ENTITY	Interleukin-17A Induces IL-1b Secretion From RPE Cells Via the NLRP3 Inflammasome .
26877061	0	IL-1b	63,68	NLRP3	34,39	IL-1b	NLRP3	3553	114548	Gene	Gene	secretion|compound|START_ENTITY secretion|nummod|END_ENTITY	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1b secretion in response to ATP .
26901245	0	IL-1b	110,115	NLRP3	35,40	IL-1b	NLRP3	3553	114548	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1b in the HUVEC Endothelial Cell Line .
26959386	0	IL-1b	30,35	NLRP3	106,111	IL-1b	NLRP3	3553	114548	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|advcl|activating activating|dobj|inflammasome inflammasome|compound|END_ENTITY	Trichomonas_vaginalis induces IL-1b production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux .
22100755	0	IL-1b	39,44	Nlrp3	80,85	IL-1b	Nlrp3	3553	114548	Gene	Gene	release|compound|START_ENTITY trigger|dobj|release trigger|nmod|activation activation|amod|END_ENTITY	Double-walled carbon nanotubes trigger IL-1b release in human monocytes through Nlrp3 inflammasome activation .
23376234	0	IL-1b	65,70	Nlrp3	36,41	IL-1b	Nlrp3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1b secretion in association with alterations in cellular redox and energy status .
21781483	0	IL-1b	16,21	SIRT1	1,6	IL-1b	SIRT1	3553	23411	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	-LSB- SIRT1 inhibits IL-1b mRNA transcription in lipopolysaccharide tolerant THP-1 cells -RSB- .
26752489	0	IL-1b	39,44	SIRT1	0,5	IL-1b	SIRT1	3553	23411	Gene	Gene	Effect|nmod|START_ENTITY Inhibits|dobj|Effect Inhibits|nsubj|END_ENTITY	SIRT1 Inhibits the Catabolic Effect of IL-1b Through TLR2/SIRT1/NF-kB Pathway in Human Degenerative Nucleus Pulposus Cells .
23328087	0	IL-1b	48,53	TET1	0,4	IL-1b	TET1	3553	80312	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	TET1 is a negative transcriptional regulator of IL-1b in the THP-1 cell line .
21722622	0	IL-1b	28,33	TGF-b1	8,14	IL-1b	TGF-b1	281251(Tax:9913)	282089(Tax:9913)	Gene	Gene	activation|compound|START_ENTITY Role|nmod|activation Role|nmod|END_ENTITY	Role of TGF-b1 and TNF-a in IL-1b mediated activation of proMMP-9 in pulmonary artery smooth muscle cells : involvement of an aprotinin sensitive protease .
21779356	0	IL-1b	0,5	TGF-b1	15,21	IL-1b	TGF-b1	3553	7040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	IL-1b promotes TGF-b1 and IL-2 dependent Foxp3 expression in regulatory T cells .
23696858	0	IL-1b	52,57	TGF-b1	101,107	IL-1b	TGF-b1	24494(Tax:10116)	59086(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	HMGB1 accelerates alveolar epithelial repair via an IL-1b - and avb6 integrin-dependent activation of TGF-b1 .
21781483	0	IL-1b	16,21	THP-1	72,77	IL-1b	THP-1	3553	2736	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- SIRT1 inhibits IL-1b mRNA transcription in lipopolysaccharide tolerant THP-1 cells -RSB- .
23328087	0	IL-1b	48,53	THP-1	61,66	IL-1b	THP-1	3553	2736	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	TET1 is a negative transcriptional regulator of IL-1b in the THP-1 cell line .
23760261	0	IL-1b	79,84	THP-1	142,147	IL-1b	THP-1	3553	2736	Gene	Gene	production|compound|START_ENTITY production|nmod|stimulation stimulation|nmod|monocytes monocytes|compound|END_ENTITY	Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1b production following Toll-like_receptor_2 stimulation in THP-1 monocytes .
25639477	0	IL-1b	64,69	THP-1	81,86	IL-1b	THP-1	3553	2736	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Vitamin_D3 Metabolites Enhance the NLRP3-Dependent Secretion of IL-1b from Human THP-1 Monocytic Cells .
27096899	0	IL-1b	52,57	THP-1	82,87	IL-1b	THP-1	3553	2736	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|Requirements Requirements|compound|END_ENTITY	Lipopolysaccharide-Mediated Induction of Concurrent IL-1b and IL-23 Expression in THP-1 Cells Exhibits Differential Requirements for Caspase-1 and Cathepsin_B Activity .
24043885	0	IL-1b	35,40	TLR2	68,72	IL-1b	TLR2	3553	7097	Gene	Gene	START_ENTITY|nmod|monocytes monocytes|nmod|activation activation|compound|END_ENTITY	Inflammasome-mediated secretion of IL-1b in human monocytes through TLR2 activation ; modulation by dietary fatty_acids .
24323452	0	IL-1b	39,44	TLR2	49,53	IL-1b	TLR2	3553	7097	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Protein-bound polysaccharide-K induces IL-1b via TLR2 and NLRP3 inflammasome activation .
24489101	0	IL-1b	82,87	TLR4	103,107	IL-1b	TLR4	3553	7099	Gene	Gene	produce|dobj|START_ENTITY produce|nmod|stimulation stimulation|compound|END_ENTITY	Cutting edge : Endoplasmic reticulum stress licenses macrophages to produce mature IL-1b in response to TLR4 stimulation through a caspase-8 - _ and_TRIF-dependent pathway .
20493505	0	IL-1b	51,56	TNF	46,49	IL-1b	TNF	768274(Tax:9685)	493755(Tax:9685)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|appos|production	Pathogen associated molecular pattern-induced TNF , IL-1b , IL-6 and CXCL-8 production from feline whole blood culture .
21752147	0	IL-1b	57,62	TNF-a	64,69	IL-1b	TNF-a	3553	7124	Gene	Gene	START_ENTITY|appos|IL-6 IL-6|compound|END_ENTITY	In vitro secretion profile of pro-inflammatory cytokines IL-1b , TNF-a , IL-6 , and of human beta-defensins _ -LRB- HBD -RRB- -1 , HBD-2 , and HBD-3 from human chorioamniotic membranes after selective stimulation with Gardnerella_vaginalis .
21913564	0	IL-1b	59,64	TNF-a	72,77	IL-1b	TNF-a	3553	7124	Gene	Gene	IL-6|amod|START_ENTITY Studies|amod|IL-6 Studies|acl|END_ENTITY	-LSB- Studies on the level of proinflammatory cytokines IIL-1a , IL-1b , IL-6 , TNF-a in pregnant women with acute pyelonephritis -RSB- .
21930349	0	IL-1b	60,65	TNF-a	73,78	IL-1b	TNF-a	3553	7124	Gene	Gene	IL-6|amod|START_ENTITY expression|amod|IL-6 expression|appos|END_ENTITY	Immunohistochemical expression of proinflammatory cytokines IL-1b , IL-6 , TNF-a and involvement of COX-2 , quantitatively confirmed by Western blot analysis , in Wernicke 's _ encephalopathy .
22157665	0	IL-1b	36,41	TNF-a	10,15	IL-1b	TNF-a	3553	7124	Gene	Gene	START_ENTITY|compound|IL-6 IL-6|compound|END_ENTITY	Increased TNF-a , IL-6 and decreased IL-1b immunohistochemical expression by the stromal spindle-shaped cells in the central_giant_cell_granuloma_of_the_jaws .
22610149	0	IL-1b	118,123	TNF-a	111,116	IL-1b	TNF-a	3553	7124	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Recombinant human endostatin inhibits adjuvant_arthritis by down-regulating VEGF expression and suppression of TNF-a , IL-1b production .
23623770	0	IL-1b	99,104	TNF-a	9,14	IL-1b	TNF-a	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY enhances|nmod|induction enhances|nsubj|END_ENTITY	Blocking TNF-a enhances Pseudomonas_aeruginosa-induced mortality in burn mice through induction of IL-1b .
23781123	0	IL-1b	174,179	TNF-a	181,186	IL-1b	TNF-a	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Biphasic modulation of NOS expression , protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock : downstream regulation of COX-2 , IL-1b , TNF-a , IL-6 , and HMGB1 expression .
23886206	0	IL-1b	103,108	TNF-a	83,88	IL-1b	TNF-a	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|compound|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24972324	0	IL-1b	57,62	TNF-a	35,40	IL-1b	TNF-a	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|Transcription Transcription|nmod|END_ENTITY	Transcription of the gene encoding TNF-a is increased by IL-1b in rat and human islets and b-cell lines .
25434084	0	IL-1b	30,35	TNF-a	23,28	IL-1b	TNF-a	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
25507682	0	IL-1b	30,35	TNF-a	23,28	IL-1b	TNF-a	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
25732721	0	IL-1b	53,58	TNF-a	46,51	IL-1b	TNF-a	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Pre-activation of mesenchymal stem cells with TNF-a , IL-1b and nitric_oxide enhances its paracrine effects on radiation-induced intestinal_injury .
21092452	0	IL-1b	27,32	TNFa	34,38	IL-1b	TNFa	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The expression of mucosal IL-1b , TNFa and serotonin_transporter in chronic visceral_hypersensitivity rats -RSB- .
25025954	0	IL-1b	87,92	Th1	146,149	IL-1b	Th1	3553	51497	Gene	Gene	cytokines|amod|START_ENTITY Involvement|nmod|cytokines Involvement|nmod|cytokines cytokines|amod|END_ENTITY	Ex vivo PBMC cytokine profile in familial_Mediterranean_fever patients : Involvement of IL-1b , IL-1a and Th17-associated cytokines and decrease of Th1 and Th2 cytokines .
26641550	0	IL-1b	94,99	Th1	51,54	IL-1b	Th1	3553	51497	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1b and Inhibition of PGE2 .
24993819	0	IL-1b	0,5	Wnt5a	34,39	IL-1b	Wnt5a	3553	7474	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	IL-1b mediates MCP-1 induction by Wnt5a in gastric_cancer cells .
23174018	0	IL-1b	0,5	Zeb1	71,75	IL-1b	Zeb1	3553	6935	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|amod|END_ENTITY	IL-1b promotes stemness and invasiveness of colon_cancer cells through Zeb1 activation .
23266381	0	IL-1b	70,75	caspase-1	90,99	IL-1b	caspase-1	3553	834	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Blockade of tumor necrosis factor-a converting enzyme -LRB- TACE -RRB- enhances IL-1b and IFN-y via caspase-1 activation : a probable cause for loss of efficacy of TACE inhibitors in humans ?
23884363	0	IL-1b	108,113	caspase-1	65,74	IL-1b	caspase-1	3553	834	Gene	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion END_ENTITY|acl:relcl|mediates	Dengue_virus-infected human monocytes trigger late activation of caspase-1 , which mediates pro-inflammatory IL-1b secretion and pyroptosis .
24275551	0	IL-1b	62,67	caspase-1	108,117	IL-1b	caspase-1	3553	834	Gene	Gene	-18|dep|START_ENTITY secretion|nmod|-18 enhances|dobj|secretion enhances|nmod|monocytes monocytes|nmod|activation activation|nmod|END_ENTITY	Leptin enhances the secretion of interleukin _ -LRB- IL -RRB- -18 , but not IL-1b , from human monocytes via activation of caspase-1 .
26266796	0	IL-1b	0,5	caspase-1	111,120	IL-1b	caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	processing|amod|START_ENTITY dependent|nsubj|processing dependent|advcl|END_ENTITY	IL-1b processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1 .
22267217	0	IL-1b	81,86	caspase-8	106,115	IL-1b	caspase-8	3553	841	Gene	Gene	START_ENTITY|nmod|inflammasome inflammasome|amod|END_ENTITY	Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1b via a noncanonical caspase-8 inflammasome .
21885043	0	IL-1b	51,56	cyclooxygenase-2	18,34	IL-1b	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The gene encoding cyclooxygenase-2 is regulated by IL-1b and prostaglandins in 832/13 rat insulinoma cells .
22878602	0	IL-1b	119,124	cyclooxygenase-2	43,59	IL-1b	cyclooxygenase-2	3553	5743	Gene	Gene	exposed|nmod|START_ENTITY exposed|nsubj|inhibitor inhibitor|amod|END_ENTITY	In vitro effects of VA441 , a new selective cyclooxygenase-2 inhibitor , on human osteoarthritic chondrocytes exposed to IL-1b .
21041719	0	IL-1b	70,75	death-associated_protein_kinase	17,48	IL-1b	death-associated protein kinase	3553	1612	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|END_ENTITY	Tumor suppressor death-associated_protein_kinase is required for full IL-1b production .
21035557	0	IL-1b	26,31	iNOS	65,69	IL-1b	iNOS	3553	4843	Gene	Gene	inducible|amod|START_ENTITY synthase|amod|inducible synthase|appos|END_ENTITY	Selenomethionine inhibits IL-1b inducible nitric_oxide synthase -LRB- iNOS -RRB- and cyclooxygenase_2 -LRB- COX2 -RRB- expression in primary human chondrocytes .
22342441	0	IL-1b	184,189	iNOS	210,214	IL-1b	iNOS	16176(Tax:10090)	18126(Tax:10090)	Gene	Gene	TNF-a|dep|START_ENTITY cytokines|appos|TNF-a cytokines|dep|END_ENTITY	Inhibitory effects of bioactive leads isolated from Pseudomonas_aeruginosa PS3 and Pseudomonas_fluorescens PS7 on MAP kinases and down regulation of pro inflammatory cytokines -LRB- TNF-a , IL-1b -RRB- and mediators -LRB- NO , iNOS and COX -RRB- .
23886206	0	IL-1b	103,108	iNOS	90,94	IL-1b	iNOS	16176(Tax:10090)	18126(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24014650	0	IL-1b	41,46	iNOS	14,18	IFN-y	iNOS	3458	4843	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Regulation of iNOS gene transcription by IL-1b and IFN-y requires a coactivator exchange mechanism .
25160751	0	IL-1b	37,42	iNOS	52,56	IL-1b	iNOS	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	Glycogen synthase kinase 3 regulates IL-1b mediated iNOS expression in hepatocytes by down-regulating c-Jun .
21424904	0	IL-1b	52,57	interleukin-1_beta	32,50	IL-1b	interleukin-1 beta	3553	3553	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Association between circulating interleukin-1_beta -LRB- IL-1b -RRB- levels and IL-1b C-511T polymorphism with cervical_cancer risk in Egyptian women .
25606396	0	IL-1b	35,40	interleukin_1_beta	15,33	IL-1b	Interleukin 1 beta	3553	3553	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of interleukin_1_beta -LRB- IL-1b -RRB- polymorphism with mRNA expression and risk of non small cell lung_cancer .
27021546	0	IL-1b	36,41	miR-223	11,18	IL-1b	miR-223	3553	407008	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of miR-223 on expression of IL-1b and IL-6 in human_gingival_fibroblasts .
19570027	0	IL-1b	23,28	p75NTR	48,54	IL-1b	p75NTR	3553	4804	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Inflammatory cytokines IL-1b and TNF-a regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms .
24323452	0	IL-1b	39,44	polysaccharide-K	14,30	IL-1b	polysaccharide-K	3553	9344	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Protein-bound polysaccharide-K induces IL-1b via TLR2 and NLRP3 inflammasome activation .
21567074	0	IL-1b	126,131	prostaglandin_D2	83,99	IL-1b	prostaglandin D2	3553	5730	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Single impact trauma in human early-stage osteoarthritic cartilage : implication of prostaglandin_D2 but no additive effect of IL-1b on cell survival .
15142264	0	IL-1beta	110,118	AP-1	10,14	IL-1beta	AP-1	3553	3726	Gene	Gene	cytokines|dobj|START_ENTITY cytokines|nsubj|END_ENTITY	Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta , tumor_necrosis_factor_alpha and IL-17 in rheumatoid synoviocytes .
17014957	0	IL-1beta	86,94	Alpha-MSH	0,9	IL-1beta	Alpha-MSH	3553	5443	Gene	Gene	modulate|nmod|START_ENTITY modulate|nsubj|END_ENTITY	Alpha-MSH and gamma-MSH modulate early release of hypothalamic PGE2 and NO induced by IL-1beta differently .
16621158	0	IL-1beta	0,8	BDNF	23,27	IL-1beta	BDNF	24494(Tax:10116)	24225(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	IL-1beta regulation of BDNF expression in rat cultured hypothalamic neurons depends on the presence of glial cells .
11854037	0	IL-1beta	0,8	C/EBP-beta	19,29	IL-1beta	C/EBP-beta	3553	1051	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	IL-1beta activates C/EBP-beta and delta in human enterocytes through a mitogen-activated protein kinase signaling pathway .
16581045	0	IL-1beta	0,8	CCL28	54,59	IL-1beta	CCL28	3553	56477	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	IL-1beta and TNF-alpha induce increased expression of CCL28 by airway epithelial cells via an NFkappaB-dependent pathway .
10960082	0	IL-1beta	46,54	COX-2	13,18	IL-1beta	COX-2	16176(Tax:10090)	17709(Tax:10090)	Gene	Gene	mediated|nsubjpass|START_ENTITY biosynthesis|advcl|mediated biosynthesis|nsubj|Induction Induction|nmod|END_ENTITY	Induction of COX-2 and PGE -LRB- 2 -RRB- biosynthesis by IL-1beta is mediated by PKC and mitogen-activated protein kinases in murine astrocytes .
17234889	0	IL-1beta	0,8	COX-2	100,105	IL-1beta	COX-2	24494(Tax:10116)	26198(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|dep|involvement involvement|nmod|induction induction|compound|END_ENTITY	IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system : involvement of COX-2 and iNOS induction in muscularis resident macrophages .
17719733	0	IL-1beta	34,42	COX-2	44,49	IL-1beta	COX-2	100008990(Tax:9986)	808233(Tax:9986)	Gene	Gene	MCP-1|amod|START_ENTITY MCP-1|amod|END_ENTITY	The time-dependent expressions of IL-1beta , COX-2 , MCP-1 mRNA in skin wounds of rabbits .
9266823	0	IL-1beta	97,105	COX-2	72,77	IL-1beta	COX-2	3553	4513	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta .
18046562	0	IL-1beta	72,80	CXCL10	46,52	IL-1beta	CXCL10	3553	3627	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines .
15350541	0	IL-1beta	0,8	Cx32	33,37	IL-1beta	Cx32	24494(Tax:10116)	29584(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	IL-1beta regulates expression of Cx32 , occludin , and claudin-2 of rat hepatocytes via distinct signal transduction pathways .
16436473	0	IL-1beta	65,73	ERK1/2	33,39	IL-1beta	ERK1/2	24494(Tax:10116)	50689;116590	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells .
12072388	0	IL-1beta	33,41	Estrogen_receptor_alpha	0,23	IL-1beta	Estrogen receptor alpha	16176(Tax:10090)	13982(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Estrogen_receptor_alpha inhibits IL-1beta induction of gene expression in the mouse liver .
18224250	0	IL-1beta	0,8	FHL2	19,23	IL-1beta	FHL2	3553	2274	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IL-1beta regulates FHL2 and other cytoskeleton-related genes in human chondrocytes .
16720054	0	IL-1beta	45,53	Glucagon-like_peptide-1	0,23	IL-1beta	Glucagon-like peptide-1	24494(Tax:10116)	24952(Tax:10116)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Glucagon-like_peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes .
12500176	0	IL-1beta	42,50	HGF	0,3	IL-1beta	HGF	100008990(Tax:9986)	100316908(Tax:9986)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	HGF regulation of RPE proliferation in an IL-1beta / retinal hole-induced rabbit model of PVR .
20726333	0	IL-1beta	207,215	HGF	26,29	IL-1beta	HGF	3553	3082	Gene	Gene	camptothecin|compound|START_ENTITY incubation|nmod|camptothecin heat_shock|nmod|incubation heat_shock|nsubj|Hepatocyte_growth_factor Hepatocyte_growth_factor|appos|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- , heat_shock proteins -LRB- HSPs -RRB- and multidrug resistance protein -LRB- MRP -RRB- expression in co-culture of colon_tumor spheroids with normal cells after incubation with interleukin-1beta -LRB- IL-1beta -RRB- and/or camptothecin -LRB- CPT-11 -RRB- .
17464544	0	IL-1beta	34,42	Hepatocyte_growth_factor	0,24	IL-1beta	Hepatocyte growth factor	3553	3082	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Hepatocyte_growth_factor enhances IL-1beta stimulated IL-8 secretion by Caco-2 epithelial cells .
20726333	0	IL-1beta	207,215	Hepatocyte_growth_factor	0,24	IL-1beta	Hepatocyte growth factor	3553	3082	Gene	Gene	camptothecin|compound|START_ENTITY incubation|nmod|camptothecin heat_shock|nmod|incubation heat_shock|nsubj|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- , heat_shock proteins -LRB- HSPs -RRB- and multidrug resistance protein -LRB- MRP -RRB- expression in co-culture of colon_tumor spheroids with normal cells after incubation with interleukin-1beta -LRB- IL-1beta -RRB- and/or camptothecin -LRB- CPT-11 -RRB- .
11567773	0	IL-1beta	20,28	IFN-alpha	49,58	IL-1beta	IFN-alpha	395196(Tax:9031)	396398(Tax:9031)	Gene	Gene	TGF-beta4|compound|START_ENTITY TGF-beta4|amod|END_ENTITY	Adjuvant effects of IL-1beta , IL-2 , IL-8 , IL-15 , IFN-alpha , IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina .
11567773	0	IL-1beta	20,28	IFN-gamma	60,69	IL-1beta	IFN-alpha	395196(Tax:9031)	396398(Tax:9031)	Gene	Gene	TGF-beta4|compound|START_ENTITY TGF-beta4|amod|END_ENTITY	Adjuvant effects of IL-1beta , IL-2 , IL-8 , IL-15 , IFN-alpha , IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina .
15383953	0	IL-1beta	52,60	IFN-gamma	68,77	IL-1beta	IFN-gamma	3553	3458	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	-LSB- Evaluation of proinflammatory cytokine -LRB- TNF-alpha , IL-1beta , IL-6 , IFN-gamma -RRB- concentrations in serum and cerebrospinal fluid of patients with neuroborreliosis -RSB- .
16263000	0	IL-1beta	102,110	IFN-gamma	114,123	IL-1beta	IFN-gamma	3553	3458	Gene	Gene	START_ENTITY|nmod|assay assay|amod|END_ENTITY	Polymorphism in IL1B : IL1B-511 association with tuberculosis and decreased lipopolysaccharide-induced IL-1beta in IFN-gamma primed ex-vivo whole blood assay .
17786499	0	IL-1beta	71,79	IFN-gamma	92,101	IL-1beta	IFN-gamma	24494(Tax:10116)	25712(Tax:10116)	Gene	Gene	bFGF|compound|START_ENTITY bFGF|appos|END_ENTITY	Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta , TNF-alpha , IFN-gamma , TGF-beta , bFGF , and PDGF in rat 's gingiva .
17158965	0	IL-1beta	25,33	IFNgamma	0,8	IL-1beta	IFNgamma	3553	3458	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central_nervous_system_tuberculosis .
18805021	0	IL-1beta	23,31	IFNgamma	65,73	IL-1beta	IFNgamma	3553	3458	Gene	Gene	role|nmod|START_ENTITY role|nmod|activity activity|compound|END_ENTITY	A synergistic role for IL-1beta and TNFalpha in monocyte-derived IFNgamma inducing activity .
12022703	0	IL-1beta	19,27	IL-18	10,15	IL-1beta	IL-18	3553	3606	Gene	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of IL-18 on IL-1beta and sIL-1RII production by human neutrophils .
16154204	0	IL-1beta	26,34	IL-18	49,54	IL-1beta	IL-18	3553	3606	Gene	Gene	IL-12|compound|START_ENTITY IL-12|dep|END_ENTITY	Proinflammatory cytokine -LRB- IL-1beta , IL-6 , IL-12 , IL-18 and TNF-alpha -RRB- levels in sera of patients with subacute cutaneous lupus_erythematosus -LRB- SCLE -RRB- .
11027520	0	IL-1beta	48,56	IL-1Ra	88,94	IL-1beta	IL-1Ra	3553	3557	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Imbalance production between interleukin-1beta -LRB- IL-1beta -RRB- and IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- in bronchial_asthma .
15020061	0	IL-1beta	64,72	IL-1Ra	73,79	IL-1beta	IL-1Ra	24494(Tax:10116)	60582(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|dep|balance balance|compound|END_ENTITY	Influence of the course of brain_inflammation on the endogenous IL-1beta / IL-1Ra balance in the model of brain_delayed-type_hypersensitivity response to bacillus Calmette-Gu rin in Lewis rats .
15900570	0	IL-1beta	63,71	IL-1Ra	15,21	IL-1beta	IL-1Ra	3553	3557	Gene	Gene	polymorphisms|compound|START_ENTITY association|nmod|polymorphisms Association|nmod|association Association|nmod|polymorphism polymorphism|compound|END_ENTITY	Association of IL-1Ra gene polymorphism , but no association of IL-1beta and IL-4 gene polymorphisms , with Kawasaki_disease .
19618085	0	IL-1beta	52,60	IL-1Ra	101,107	IL-1beta	IL-1Ra	3553	3557	Gene	Gene	expression|nmod|START_ENTITY Evaluation|nmod|expression Evaluation|appos|END_ENTITY	Evaluation of the expression of interleukin_1_beta -LRB- IL-1beta -RRB- and interleukin_1_receptor_antagonist -LRB- IL-1Ra -RRB- in leprosy patients .
8608647	0	IL-1beta	16,24	IL-1Ra	55,61	IL-1beta	IL-1Ra	3553	3557	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of IL-1beta and IL-1_receptor_antagonist -LRB- IL-1Ra -RRB- in bronchoalveolar lavage fluid -LRB- BALF -RRB- in patients with diffuse_panbronchiolitis -LRB- DPB -RRB- .
12355453	0	IL-1beta	19,27	IL-1_receptor_antagonist	79,103	IL-1beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	control|nmod|START_ENTITY bioactivity|nsubj|control bioactivity|nmod|regulation regulation|nmod|END_ENTITY	Genetic control of IL-1beta bioactivity through differential regulation of the IL-1_receptor_antagonist .
15141093	0	IL-1beta	81,89	IL-1_receptor_antagonist	41,65	IL-1beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Leptin modulates beta cell expression of IL-1_receptor_antagonist and release of IL-1beta in human islets .
16553947	0	IL-1beta	128,136	IL-1_receptor_antagonist	137,161	IL-1beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	shift|nmod|START_ENTITY leading|nmod|shift DNA|dep|leading DNA|parataxis|END_ENTITY	Beta - -LRB- 1 -- > 3 -RRB- - D-glucan modulates DNA binding of nuclear factors kappaB , AT and IL-6 leading to an anti-inflammatory shift of the IL-1beta / IL-1_receptor_antagonist ratio .
17182583	0	IL-1beta	23,31	IL-1_receptor_antagonist	45,69	IL-1beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Opposite regulation of IL-1beta and secreted IL-1_receptor_antagonist production by phosphatidylinositide-3 kinases in human monocytes activated by lipopolysaccharides or contact with T cells .
19255448	0	IL-1beta	83,91	IL-1_receptor_antagonist	29,53	IL-1beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Glatiramer_acetate increases IL-1_receptor_antagonist but decreases T cell-induced IL-1beta in human monocytes and multiple_sclerosis .
9112403	0	IL-1beta	34,42	IL-1_receptor_antagonist	97,121	IL-1beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	effects|nmod|START_ENTITY counteracted|nsubjpass|effects counteracted|nmod|END_ENTITY	The effects of interleukin-1beta -LRB- IL-1beta -RRB- on human thyrocyte functions are counteracted by the IL-1_receptor_antagonist .
9565638	0	IL-1beta	133,141	IL-1_receptor_antagonist	97,121	IL-1beta	IL-1 receptor antagonist	16176(Tax:10090)	16181(Tax:10090)	Gene	Gene	crucial|nsubj|START_ENTITY shows|ccomp|crucial shows|nsubj|END_ENTITY	Production of mice deficient in genes for interleukin _ -LRB- IL -RRB- -1 alpha , IL-1beta , IL-1alpha / beta , and IL-1_receptor_antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion .
9949173	0	IL-1beta	53,61	IL-1_receptor_antagonist	79,103	IL-1beta	IL-1 receptor antagonist	3553	3557	Gene	Gene	START_ENTITY|nmod|production production|nmod|cells cells|amod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- and IL-13 enhance the effect of IL-1beta on production of IL-1_receptor_antagonist by human primary hepatocytes and hepatoma HepG2 cells : differential effect on C-reactive_protein production .
9495511	0	IL-1beta	11,19	IL-1alpha	0,9	IL-1beta	IL-1alpha	16176(Tax:10090)	16175(Tax:10090)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|amod|END_ENTITY	IL-1alpha , IL-1beta , IL-6 , and TNF-alpha steady-state mRNA levels analyzed by reverse transcription-competitive PCR in bone marrow of gonadectomized mice .
20361987	0	IL-1beta	65,73	IL-1ra	102,108	IL-1beta	IL-1ra	24494(Tax:10116)	60582(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII , and drives an overall anti-inflammatory phenotype in rat cortex .
16489252	0	IL-1beta	21,29	IL-2	31,35	IL-1beta	IL-2	3553	3558	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
9262280	0	IL-1beta	33,41	IL-2	43,47	IL-1beta	IL-2	3553	3558	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Seminal cytokine concentrations -LRB- IL-1beta , IL-2 , IL-6 , sR IL-2 , sR IL-6 -RRB- , semen parameters and blood hormonal status in male_infertility .
9262280	0	IL-1beta	33,41	IL-2	58,62	IL-1beta	IL-2	3553	3558	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Seminal cytokine concentrations -LRB- IL-1beta , IL-2 , IL-6 , sR IL-2 , sR IL-6 -RRB- , semen parameters and blood hormonal status in male_infertility .
10547271	0	IL-1beta	108,116	IL-6	118,122	IL-1beta	IL-6	3553	3569	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Protein kinase c-dependent pathway is critical for the production of pro-inflammatory cytokines -LRB- TNF-alpha , IL-1beta , IL-6 -RRB- .
10579318	0	IL-1beta	113,121	IL-6	51,55	IL-1beta	IL-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY elevated|nmod|injection elevated|nsubj|levels levels|nmod|interleukin-6 interleukin-6|appos|END_ENTITY	Mechanisms by which blood levels of interleukin-6 -LRB- IL-6 -RRB- are elevated after intracerebroventricular injection of IL-1beta in the rat : neural versus humoral control .
11446462	0	IL-1beta	19,27	IL-6	49,53	IL-1beta	IL-6	3553	3569	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Regulatory role of IL-1beta in the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas_aeruginosa colonization .
12233876	0	IL-1beta	87,95	IL-6	105,109	IL-1beta	IL-6	3553	3569	Gene	Gene	START_ENTITY|acl|induced induced|dobj|production production|compound|END_ENTITY	Androgen receptors in human synoviocytes and androgen regulation of interleukin_1beta -LRB- IL-1beta -RRB- induced IL-6 production : a link between hypoandrogenicity and rheumatoid_arthritis ?
12676746	0	IL-1beta	0,8	IL-6	20,24	IL-1beta	IL-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa_B .
12909303	0	IL-1beta	130,138	IL-6	140,144	IL-1beta	IL-6	3553	3569	Gene	Gene	IL-8|amod|START_ENTITY IL-8|amod|END_ENTITY	Approach to discriminate subgroups in multiple_sclerosis with cerebrospinal fluid -LRB- CSF -RRB- basic inflammation indices and TNF-alpha , IL-1beta , IL-6 , IL-8 .
15195698	0	IL-1beta	19,27	IL-6	36,40	IL-1beta	IL-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|compound|END_ENTITY	p38_MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts .
15341921	0	IL-1beta	0,8	IL-6	22,26	IL-1beta	IL-6	3553	3569	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK , p38 and NFkappaB signaling pathways .
15383953	0	IL-1beta	52,60	IL-6	62,66	IL-1beta	IL-6	3553	3569	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|IFN-gamma IFN-gamma|compound|END_ENTITY	-LSB- Evaluation of proinflammatory cytokine -LRB- TNF-alpha , IL-1beta , IL-6 , IFN-gamma -RRB- concentrations in serum and cerebrospinal fluid of patients with neuroborreliosis -RSB- .
16154204	0	IL-1beta	26,34	IL-6	36,40	IL-1beta	IL-6	3553	3569	Gene	Gene	IL-12|compound|START_ENTITY IL-12|dep|END_ENTITY	Proinflammatory cytokine -LRB- IL-1beta , IL-6 , IL-12 , IL-18 and TNF-alpha -RRB- levels in sera of patients with subacute cutaneous lupus_erythematosus -LRB- SCLE -RRB- .
16764689	0	IL-1beta	94,102	IL-6	105,109	IL-1beta	IL-6	3553	3569	Gene	Gene	START_ENTITY|appos|responses responses|amod|END_ENTITY	Pregnancy , but not the allergic status , influences spontaneous and induced interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , IL-10 and IL-12 responses .
17047289	0	IL-1beta	21,29	IL-6	59,63	IL-1beta	IL-6	3553	3569	Gene	Gene	circulating|dobj|START_ENTITY END_ENTITY|dep|circulating	Elevated circulating IL-1beta and TNF-alpha , and unaltered IL-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome .
18060414	0	IL-1beta	35,43	IL-6	45,49	IL-1beta	IL-6	3553	3569	Gene	Gene	importance|nmod|START_ENTITY importance|appos|levels levels|compound|IL-8 IL-8|compound|END_ENTITY	The prognostic importance of serum IL-1beta , IL-6 , IL-8 and TNF-alpha levels compared to trauma scoring systems for early mortality in children with blunt_trauma .
9712106	0	IL-1beta	46,54	IL-6	67,71	IL-1beta	IL-6	3553	3569	Gene	Gene	START_ENTITY|acl|stimulated stimulated|dobj|END_ENTITY	Nitric_oxide downregulates interleukin_1beta -LRB- IL-1beta -RRB- stimulated IL-6 , IL-8 , and prostaglandin_E2 production by human chondrocytes .
20497296	0	IL-1beta	12,20	IL-7	32,36	IL-1beta	IL-7	3553	3574	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	The role of IL-1beta in reduced IL-7 production by stromal and epithelial cells : a model for impaired_T-cell_numbers_in_the_gut_during_HIV-1_infection .
12045890	0	IL-1beta	12,20	IL-8	42,46	IL-1beta	IL-8	3553	3576	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of IL-1beta in the regulation of IL-8 and IL-6 in human corneal epithelial cells during Pseudomonas_aeruginosa colonization .
15514971	0	IL-1beta	0,8	IL-8	34,38	IL-1beta	IL-8	3553	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|stabilization stabilization|nmod|mRNA mRNA|compound|END_ENTITY	IL-1beta induces stabilization of IL-8 mRNA in malignant breast_cancer cells via the 3 ' untranslated region : Involvement of divergent RNA-binding factors HuR , KSRP and TIAR .
15939312	0	IL-1beta	0,8	IL-8	17,21	IL-1beta	IL-8	3553	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids .
16489252	0	IL-1beta	21,29	IL-8	43,47	IL-1beta	IL-8	3553	3576	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
17086498	0	IL-1beta	45,53	IL-8	57,61	IL-1beta	IL-8	3553	3576	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon_carcinoma cell line -LRB- Caco-2 -RRB- .
17464544	0	IL-1beta	34,42	IL-8	54,58	IL-1beta	IL-8	3553	3576	Gene	Gene	START_ENTITY|acl|stimulated stimulated|dobj|secretion secretion|compound|END_ENTITY	Hepatocyte_growth_factor enhances IL-1beta stimulated IL-8 secretion by Caco-2 epithelial cells .
17586709	0	IL-1beta	60,68	IL-8	14,18	IL-1beta	IL-8	3553	3576	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	Force-induced IL-8 from periodontal ligament cells requires IL-1beta .
18060414	0	IL-1beta	35,43	IL-8	51,55	IL-1beta	IL-8	3553	3576	Gene	Gene	importance|nmod|START_ENTITY importance|appos|levels levels|compound|END_ENTITY	The prognostic importance of serum IL-1beta , IL-6 , IL-8 and TNF-alpha levels compared to trauma scoring systems for early mortality in children with blunt_trauma .
19014534	0	IL-1beta	0,8	IL-8	33,37	IL-1beta	IL-8	3553	3576	Gene	Gene	involved|nsubj|START_ENTITY involved|nmod|release release|amod|END_ENTITY	IL-1beta differently involved in IL-8 and FGF-2 release in crystalline silica-treated lung cell co-cultures .
20194723	0	IL-1beta	25,33	IL-8	45,49	IL-1beta	IL-8	3553	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene_B4_receptor_2-linked pathway , contributing to angiogenesis .
20207110	0	IL-1beta	27,35	IL-8	67,71	IL-1beta	IL-8	3553	3576	Gene	Gene	cytokines|appos|START_ENTITY END_ENTITY|nsubj|cytokines	Proinflammatory cytokines -LRB- IL-1beta and TNF-alpha -RRB- and chemokines -LRB- IL-8 and MIP-1alpha -RRB- as markers of peri-implant tissue condition .
20483667	0	IL-1beta	11,19	IL-8	78,82	IL-1beta	IL-8	3553	3576	Gene	Gene	blockade|compound|START_ENTITY reduces|nsubj|blockade reduces|dobj|expression expression|nmod|fashion fashion|amod|dependent dependent|amod|END_ENTITY	Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes .
9475356	0	IL-1beta	35,43	IL-8	27,31	IL-1beta	IL-8	3553	3576	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of IL-8 by IL-1beta and TNFalpha_in_hyaline_membrane_disease .
9558101	0	IL-1beta	20,28	IL-8	104,108	IL-1beta	IL-8	3553	3576	Gene	Gene	START_ENTITY|dep|effects effects|nmod|release release|compound|END_ENTITY	Lymphocytes produce IL-1beta in response to Fcgamma receptor cross-linking : effects on parenchymal cell IL-8 release .
10984364	0	IL-1beta	52,60	IL-9	0,4	IL-1beta	IL-9	3553	3578	Gene	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|compound|END_ENTITY	IL-9 expression by human eosinophils : regulation by IL-1beta and TNF-alpha .
19016479	0	IL-1beta	37,45	IL1B	52,56	IL-1beta	IL1B	3553	3553	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Tagging SNP association study of the IL-1beta gene -LRB- IL1B -RRB- and childhood-onset_mood_disorders .
10498857	0	IL-1beta	19,27	Interleukin-1beta	0,17	IL-1beta	Interleukin-1beta	24494(Tax:10116)	24494(Tax:10116)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Interleukin-1beta -LRB- IL-1beta -RRB- inhibition : a possible mechanism for the anti-inflammatory potency of liposomally conjugated methotrexate formulations in arthritis .
15996190	0	IL-1beta	72,80	JNK	109,112	IL-1beta	JNK	3553	5599	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|pathway pathway|compound|END_ENTITY	Actinobacillus_actinomycetemcomitans Y4 capsular polysaccharide induces IL-1beta mRNA expression through the JNK pathway in differentiated THP-1 cells .
15141093	0	IL-1beta	81,89	Leptin	0,6	IL-1beta	Leptin	3553	3952	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Leptin modulates beta cell expression of IL-1_receptor_antagonist and release of IL-1beta in human islets .
11866893	0	IL-1beta	12,20	MCP-1	76,81	IL-1beta	MCP-1	3553	6347	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of IL-1beta , TNF-alpha and lipopolysaccharide on the expression of MCP-1 in human umbilical vein endothelial cells -RSB- .
11527379	0	IL-1beta	27,35	MEK1	68,72	IL-1beta	MEK1	16176(Tax:10090)	26395(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral_ischemia in mice .
9038318	0	IL-1beta	63,71	MIP-1beta	204,213	IL-1beta	MIP-1beta	16176(Tax:10090)	20303(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of mannose receptor in cytokine interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , and granulocyte-macrophage_colony-stimulating_factor responses , but not in chemokine macrophage_inflammatory_protein_1beta -LRB- MIP-1beta -RRB- , MIP-2 , and KC responses , caused by attachment of Candida_albicans to macrophages .
9038318	0	IL-1beta	63,71	MIP-2	216,221	IL-1beta	MIP-2	16176(Tax:10090)	20310(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of mannose receptor in cytokine interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , and granulocyte-macrophage_colony-stimulating_factor responses , but not in chemokine macrophage_inflammatory_protein_1beta -LRB- MIP-1beta -RRB- , MIP-2 , and KC responses , caused by attachment of Candida_albicans to macrophages .
12387824	0	IL-1beta	0,8	MMP-9	17,22	IL-1beta	MMP-9	16176(Tax:10090)	17395(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells .
17158965	0	IL-1beta	25,33	MMP-9	49,54	IL-1beta	MMP-9	3553	4318	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nmod|secretion secretion|compound|END_ENTITY	IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central_nervous_system_tuberculosis .
19455716	0	IL-1beta	0,8	MMP-9	17,22	IL-1beta	MMP-9	24494(Tax:10116)	81687(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-1beta induces MMP-9 expression via a Ca2 + - dependent CaMKII/JNK/c-JUN cascade in rat brain astrocytes .
16459052	0	IL-1beta	28,36	MMP13	59,64	IL-1beta	MMP13	3553	4322	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|nmod|END_ENTITY	TAK1 downregulation reduces IL-1beta induced expression of MMP13 , MMP1 and TNF-alpha .
14527933	0	IL-1beta	77,85	MUC5AC	14,20	IL-1beta	MUC5AC	3553	4586	Gene	Gene	surface|nmod|START_ENTITY surface|nsubj|Regulation Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia .
19841186	0	IL-1beta	42,50	MUC5AC	21,27	IL-1beta	MUC5AC	3553	4586	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of airway MUC5AC expression by IL-1beta and IL-17A ; the NF-kappaB paradigm .
19302792	0	IL-1beta	49,57	Matrix_metalloproteinase-1	0,26	IL-1beta	Matrix metalloproteinase-1	3553	4312	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Matrix_metalloproteinase-1 expression induced by IL-1beta requires acid_sphingomyelinase .
11027635	0	IL-1beta	43,51	Monocyte_chemotactic_protein_1	0,30	IL-1beta	Monocyte chemotactic protein 1	3553	6347	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Monocyte_chemotactic_protein_1 upregulates IL-1beta expression in human monocytes .
10638662	0	IL-1beta	0,8	NF-kappaB	22,31	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	induction|amod|START_ENTITY induction|nmod|activation activation|amod|END_ENTITY	IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling .
11076795	0	IL-1beta	0,8	NF-kappaB	84,93	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	IL-1beta induces eotaxin gene transcription in A549 airway epithelial cells through NF-kappaB .
15820746	0	IL-1beta	0,8	NF-kappaB	73,82	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	stimulates|amod|START_ENTITY argininosuccinate_synthetase|nsubj|stimulates argininosuccinate_synthetase|nmod|END_ENTITY	IL-1beta stimulates argininosuccinate_synthetase gene expression through NF-kappaB in Caco-2 cells .
16112536	0	IL-1beta	23,31	NF-kappaB	47,56	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activation activation|amod|END_ENTITY	Effect of myrrh oil on IL-1beta stimulation of NF-kappaB activation and PGE -LRB- 2 -RRB- production in human gingival fibroblasts and epithelial cells .
16617094	0	IL-1beta	48,56	NF-kappaB	80,89	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	muscle|nmod|START_ENTITY regulation|nmod|muscle regulation|dep|role role|nmod|kinases kinases|compound|END_ENTITY	GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha : role of NF-kappaB and MAP kinases .
16723203	0	IL-1beta	59,67	NF-kappaB	137,146	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	pyrrolidine_dithiocarbamate|amod|START_ENTITY pyrrolidine_dithiocarbamate|acl|pointing pointing|nmod|dependence dependence|amod|END_ENTITY	The NF-kappaB inhibitor pyrrolidine_dithiocarbamate blocks IL-1beta induced hyaluronan_synthase_1 -LRB- HAS1 -RRB- mRNA transcription , pointing at NF-kappaB dependence of the gene HAS1 .
16723203	0	IL-1beta	59,67	NF-kappaB	4,13	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	pyrrolidine_dithiocarbamate|amod|START_ENTITY pyrrolidine_dithiocarbamate|amod|END_ENTITY	The NF-kappaB inhibitor pyrrolidine_dithiocarbamate blocks IL-1beta induced hyaluronan_synthase_1 -LRB- HAS1 -RRB- mRNA transcription , pointing at NF-kappaB dependence of the gene HAS1 .
19481766	0	IL-1beta	20,28	NF-kappaB	51,60	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	START_ENTITY|nmod|translocation translocation|amod|END_ENTITY	Cyclic_AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism .
19607899	1	IL-1beta	51,59	NF-kappaB	86,95	IL-1beta	NF-kappaB	16176(Tax:10090)	18033(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|advcl|blocking blocking|dobj|activation activation|compound|END_ENTITY	inhibits the production of IL-1beta and IL-6 through blocking NF-kappaB , MAPK and Akt activation in macrophages .
19648113	0	IL-1beta	103,111	NF-kappaB	156,165	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	release|appos|START_ENTITY mediated|nmod|release mediated|nmod|END_ENTITY	Injury-induced platelet-derived_growth_factor_receptor-alpha expression mediated by interleukin-1beta -LRB- IL-1beta -RRB- release and cooperative transactivation by NF-kappaB and ATF-4 : IL-1beta facilitates HDAC-1 / 2 dissociation from promoter .
19648113	0	IL-1beta	177,185	NF-kappaB	156,165	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	facilitates|compound|START_ENTITY mediated|parataxis|facilitates mediated|nmod|END_ENTITY	Injury-induced platelet-derived_growth_factor_receptor-alpha expression mediated by interleukin-1beta -LRB- IL-1beta -RRB- release and cooperative transactivation by NF-kappaB and ATF-4 : IL-1beta facilitates HDAC-1 / 2 dissociation from promoter .
19672968	0	IL-1beta	0,8	NF-kappaB	76,85	IL-1beta	NF-kappaB	16176(Tax:10090)	18033(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	IL-1beta enhances the antibacterial activity of astrocytes by activation of NF-kappaB .
19841186	0	IL-1beta	42,50	NF-kappaB	67,76	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|dep|paradigm paradigm|amod|END_ENTITY	Regulation of airway MUC5AC expression by IL-1beta and IL-17A ; the NF-kappaB paradigm .
20543863	0	IL-1beta	117,125	NF-kappaB	48,57	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	expression|compound|START_ENTITY enhancing|dobj|expression induces|advcl|enhancing induces|dobj|activation activation|amod|END_ENTITY	L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression .
8602829	0	IL-1beta	31,39	NF-kappaB	105,114	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	mRNA|nmod|START_ENTITY Inducibility|nmod|mRNA associated|nsubjpass|Inducibility associated|nmod|activity activity|compound|END_ENTITY	Inducibility of RANTES mRNA by IL-1beta in human bronchial epithelial cells is associated with increased NF-kappaB DNA binding activity .
9266823	0	IL-1beta	97,105	NF-kappaB	28,37	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	expression|nmod|START_ENTITY control|nmod|expression Evidence|nmod|control Evidence|nmod|END_ENTITY	Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta .
9652398	0	IL-1beta	46,54	NF-kappaB	87,96	IL-1beta	NF-kappaB	3553	4790	Gene	Gene	-|appos|START_ENTITY dexamethasone|nmod|- Effect|nmod|dexamethasone Effect|dep|nuclear_factor-kappaB nuclear_factor-kappaB|appos|END_ENTITY	Effect of dexamethasone on interleukin-1beta - -LRB- IL-1beta -RRB- - induced nuclear_factor-kappaB -LRB- NF-kappaB -RRB- and kappaB-dependent transcription in epithelial cells .
20561679	0	IL-1beta	96,104	NLRP3	68,73	IL-1beta	NLRP3	3553	114548	Gene	Gene	production|compound|START_ENTITY production|nummod|END_ENTITY	The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production , ROS production and endosomal rupture .
20225238	0	IL-1beta	10,18	OPG	63,66	IL-1beta	OPG	3553	4982	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of IL-1beta , PGE -LRB- 2 -RRB- , and TGF-beta1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts .
15472991	0	IL-1beta	13,21	P2X7_receptor	43,56	IL-1beta	P2X7 receptor	3553	5027	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	The cytokine IL-1beta transiently enhances P2X7_receptor expression and function in human astrocytes .
16341933	0	IL-1beta	71,79	PPAR-alpha	0,10	IL-1beta	PPAR-alpha	24494(Tax:10116)	25747(Tax:10116)	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|amod|END_ENTITY	PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats .
17032166	0	IL-1beta	42,50	RANKL	73,78	IL-1beta	RANKL	3553	8600	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	MKK3/6-p 38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells .
11385231	0	IL-1beta	81,89	RANTES	25,31	IL-1beta	RANTES	3553	6352	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|production production|compound|END_ENTITY	Interferon-gamma-induced RANTES production by human keratinocytes is enhanced by IL-1beta , TNF-alpha , IL-4 and IL-13 and is inhibited by dexamethasone and tacrolimus .
11600537	0	IL-1beta	0,8	RANTES	22,28	IL-1beta	RANTES	3553	6352	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	IL-1beta induction of RANTES -LRB- regulated upon activation , normal T cell expressed and secreted -RRB- chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappaB site in the proximal promoter .
11827101	0	IL-1beta	144,152	RANTES	81,87	IL-1beta	RANTES	3553	6352	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Cell surface phenotype and cytokine secretion in Caco-2 cell cultures : increased RANTES production and IL-2 transcription upon stimulation with IL-1beta .
8602829	0	IL-1beta	31,39	RANTES	16,22	IL-1beta	RANTES	3553	6352	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Inducibility of RANTES mRNA by IL-1beta in human bronchial epithelial cells is associated with increased NF-kappaB DNA binding activity .
19369446	0	IL-1beta	35,43	RGS4	16,20	IL-1beta	RGS4	100008990(Tax:9986)	100009014(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway .
15666191	0	IL-1beta	134,142	SHP-2	0,5	IL-1beta	SHP-2	16176(Tax:10090)	19247(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin , dephosphorylation of FAK and secretion of MMP-9 induced by IL-1beta in vivo and in vitro .
16771830	0	IL-1beta	0,8	Src	71,74	IL-1beta	Src	16176(Tax:10090)	20779(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior_hypothalamic neurons .
19587162	0	IL-1beta	0,8	TGFbeta	18,25	IL-1beta	TGFbeta	16176(Tax:10090)	21803(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IL-1beta inhibits TGFbeta in the temporomandibular_joint .
10469275	0	IL-1beta	89,97	TNF-alpha	99,108	IL-1beta	TNF-alpha	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	PTHrP|compound|START_ENTITY PTHrP|appos|END_ENTITY	A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta , TNF-alpha , PTH , PTHrP , and 1 , _ 25 -LRB- OH -RRB- 2D3 .
10525318	0	IL-1beta	46,54	TNF-alpha	35,44	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Induced heteroduplex genotyping of TNF-alpha , IL-1beta , IL-6 and IL-10 polymorphisms associated with transcriptional regulation .
11956032	0	IL-1beta	33,41	TNF-alpha	76,85	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of interleukin-1beta -LRB- IL-1beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- production by neuronal precursor cells .
12115655	0	IL-1beta	64,72	TNF-alpha	131,140	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	release|compound|START_ENTITY attenuates|dobj|release attenuates|advcl|inhibited inhibited|nsubjpass|release release|amod|END_ENTITY	Granulocyte_colony-stimulating_factor attenuates LPS-stimulated IL-1beta release via suppressed processing of proIL-1beta , whereas TNF-alpha release is inhibited on the level of proTNF-alpha formation .
12392281	0	IL-1beta	0,8	TNF-alpha	43,52	IL-1beta	TNF-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	IL-1beta and IL-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma .
12631070	0	IL-1beta	0,8	TNF-alpha	10,19	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	expression|advmod|START_ENTITY expression|nsubj|END_ENTITY	IL-1beta , TNF-alpha , TGF-beta , and bFGF expression in bone biopsies before and after parathyroidectomy .
12962834	0	IL-1beta	54,62	TNF-alpha	43,52	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Effect of proinflammatory cytokines -LRB- IL-6 , TNF-alpha , IL-1beta -RRB- on hemodynamic performance during orthotopic liver transplantation .
15047987	0	IL-1beta	69,77	TNF-alpha	79,88	IL-1beta	TNF-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	release|dep|START_ENTITY release|amod|END_ENTITY	Immunophilin ligands decrease release of pro-inflammatory cytokines -LRB- IL-1beta , TNF-alpha and IL-2 in rat astrocyte cultures exposed to simulated ischemia in vitro .
15050606	0	IL-1beta	20,28	TNF-alpha	67,76	IL-1beta	TNF-alpha	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	Interleukin-1_beta|appos|START_ENTITY induces|nsubj|Interleukin-1_beta induces|dobj|expression expression|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1beta -RRB- induces tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation .
16489252	0	IL-1beta	21,29	TNF-alpha	49,58	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
17786499	0	IL-1beta	71,79	TNF-alpha	81,90	IL-1beta	TNF-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	bFGF|compound|START_ENTITY bFGF|appos|END_ENTITY	Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta , TNF-alpha , IFN-gamma , TGF-beta , bFGF , and PDGF in rat 's gingiva .
18668392	0	IL-1beta	23,31	TNF-alpha	48,57	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	suppressed|dobj|START_ENTITY suppressed|advcl|enhancing enhancing|dobj|END_ENTITY	Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10 , when cells in whole blood were stimulated with lipopolysaccharide .
18783962	4	IL-1beta	789,797	TNF-alpha	778,787	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|amod|END_ENTITY	TNF-alpha , IL-1beta , IL-6 , and IL-10 levels were all elevated after the initiation of cardiopulmonary bypass .
20202693	0	IL-1beta	11,19	TNF-alpha	0,9	IL-1beta	TNF-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	IL-6|amod|START_ENTITY IL-6|amod|END_ENTITY	TNF-alpha , IL-1beta , IL-6 , and cinc-1 levels in rat brain after meningitis induced by Streptococcus_pneumoniae .
25291965	0	IL-1beta	17,25	TNF-alpha	33,42	IL-1beta	TNF-alpha	3553	7124	Gene	Gene	and/or|nsubj|START_ENTITY and/or|iobj|_ _|amod|END_ENTITY	Pro-inflammatory IL-1beta and/or TNF-alpha up-regulate matrix_metalloproteases-1_and _ -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis : in situ hybridization studies on a single cell level .
17164436	0	IL-1beta	75,83	UCP1	10,14	IL-1beta	UCP1	16176(Tax:10090)	22227(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice .
8605994	0	IL-1beta	54,62	VCAM-1	71,77	IL-1beta	VCAM-1	3553	7412	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|compound|END_ENTITY	A benzothiophene-carboxamide is a potent inhibitor of IL-1beta induced VCAM-1 gene expression in human endothelial cells .
12792892	0	IL-1beta	126,134	VEGF	52,56	IL-1beta	VEGF	16176(Tax:10090)	22339(Tax:10090)	Gene	Gene	overexpressing|dobj|START_ENTITY overexpressing|nsubj|Upregulation Upregulation|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the retinas of transgenic_mice overexpressing interleukin-1beta -LRB- IL-1beta -RRB- in the lens and mice undergoing retinal_degeneration .
15665043	0	IL-1beta	79,87	VEGF	20,24	IL-1beta	VEGF	3553	7422	Gene	Gene	synergy|nmod|START_ENTITY causes|parataxis|synergy causes|dobj|release release|amod|END_ENTITY	Oncostatin_M causes VEGF release from human airway smooth muscle : synergy with IL-1beta .
17035941	0	IL-1beta	0,8	VEGF	17,21	IL-1beta	VEGF	3553	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-1beta induces VEGF , independently of PGE2 induction , mainly through the PI3-K/mTOR pathway in renal mesangial cells .
12075473	0	IL-1beta	1,9	alpha-smooth_muscle_actin	21,46	IL-1beta	alpha-smooth muscle actin	24494(Tax:10116)	25365(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	-LSB- IL-1beta stimulates alpha-smooth_muscle_actin expression through JNK/p38 signal pathway in cultured rat mesangial cells -RSB- .
9013984	0	IL-1beta	108,116	alpha-smooth_muscle_actin	30,55	IL-1beta	alpha-smooth muscle actin	24494(Tax:10116)	25365(Tax:10116)	Gene	Gene	fibroblast|nmod|START_ENTITY fibroblast|dobj|expression expression|amod|END_ENTITY	Regulation of lung fibroblast alpha-smooth_muscle_actin expression , contractile phenotype , and apoptosis by IL-1beta .
18475480	0	IL-1beta	0,8	apolipoprotein_E	27,43	IL-1beta	apolipoprotein E	24494(Tax:10116)	25728(Tax:10116)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	IL-1beta and IL-6 modulate apolipoprotein_E gene expression in rat hepatocyte primary culture .
15820746	0	IL-1beta	0,8	argininosuccinate_synthetase	20,48	IL-1beta	argininosuccinate synthetase	3553	445	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	IL-1beta stimulates argininosuccinate_synthetase gene expression through NF-kappaB in Caco-2 cells .
11238007	0	IL-1beta	0,8	beta2-adrenergic_receptor	18,43	IL-1beta	beta2-adrenergic receptor	3553	154	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	IL-1beta enhances beta2-adrenergic_receptor expression in human airway epithelial cells by activating PKC .
14673956	0	IL-1beta	120,128	bombesin	93,101	IL-1beta	bombesin	3553	2922	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Proliferation of prostate_cancer cells and activity of neutral_endopeptidase is regulated by bombesin and IL-1beta with IL-1beta acting as a modulator of cellular differentiation .
8607793	0	IL-1beta	72,80	cPLA2	28,33	IL-1beta	cPLA2	3553	5321	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The concerted regulation of cPLA2 , COX2 , and lipocortin_1 expression by IL-1beta in A549 cells .
16394010	0	IL-1beta	97,105	caspase-1	123,132	IL-1beta	caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	A potent adjuvant monophosphoryl_lipid_A triggers various immune responses , but not secretion of IL-1beta or activation of caspase-1 .
21270263	0	IL-1beta	53,61	caspase-1	24,33	IL-1beta	caspase-1	3553	834	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue .
10089138	0	IL-1beta	50,58	endothelin_1	16,28	IL-1beta	endothelin 1	3553	1906	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of endothelin_1 and its precursor by IL-1beta , TNF-alpha , and TGF-beta in the PC3 human prostate_cancer cell line .
16123330	0	IL-1beta	31,39	fibrinogen	59,69	IL-1beta	fibrinogen	3553	2244	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Endothelial cell activation by IL-1beta in the presence of fibrinogen requires alphavbeta3 .
11956032	0	IL-1beta	33,41	granulocyte_macrophage-colony_stimulating_factor	90,138	IL-1beta	granulocyte macrophage-colony stimulating factor	3553	1437	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of interleukin-1beta -LRB- IL-1beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- production by neuronal precursor cells .
12714616	0	IL-1beta	72,80	hBD-2	96,101	IL-1beta	hBD-2	3553	1673	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Defensin expression by the cornea : multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells .
16257052	0	IL-1beta	112,120	hCG	145,148	IL-1beta	hCG	3553	93659	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	hCG Secretion in human choriocarcinoma JAR cells is MAPK but not Stat3 dependent : contributions of TNFalpha and IL-1beta to inflammation-induced hCG secretion .
11006448	0	IL-1beta	87,95	iNOS	47,51	IL-1beta	iNOS	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	synthase|nmod|START_ENTITY synthase|dobj|END_ENTITY	Expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in middle_ear_epithelial_cells by IL-1beta and TNF-alpha .
11989973	0	IL-1beta	26,34	iNOS	104,108	IL-1beta	iNOS	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY related|nsubjpass|effect related|nmod|END_ENTITY	The stimulatory effect of IL-1beta on the insulin secretion of rat pancreatic islet is not related with iNOS pathway .
12062366	0	IL-1beta	51,59	iNOS	13,17	IL-1beta	iNOS	3553	4843	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation : an in vitro and in vivo study .
16436473	0	IL-1beta	65,73	iNOS	57,61	IL-1beta	iNOS	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells .
16912414	0	IL-1beta	32,40	iNOS	49,53	IL-1beta	iNOS	3553	51477	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activity activity|amod|END_ENTITY	Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs .
14576830	0	IL-1beta	50,58	inducible_nitric_oxide_synthase	92,123	IL-1beta	inducible nitric oxide synthase	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta - and lipopolysaccharide-mediated inducible_nitric_oxide_synthase expression in rat intestinal epithelial cells .
18348730	0	IL-1beta	32,40	inducible_nitric_oxide_synthase	49,80	IL-1beta	inducible nitric oxide synthase	3553	4843	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Dynamic compression counteracts IL-1beta induced inducible_nitric_oxide_synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs .
9590244	0	IL-1beta	75,83	inducible_nitric_oxide_synthase	24,55	IL-1beta	inducible nitric oxide synthase	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Molecular mechanisms of inducible_nitric_oxide_synthase gene expression by IL-1beta and cAMP in rat mesangial cells .
9468219	0	IL-1beta	102,110	interleukin-1_beta	82,100	IL-1beta	interleukin-1 beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a second transcription initiation element -LRB- STIE -RRB- in the human interleukin-1_beta -LRB- IL-1beta -RRB- gene .
12588662	0	IL-1beta	52,60	interleukin-1beta	33,50	IL-1beta	interleukin-1beta	16176(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of flavone derivatives on interleukin-1beta -LRB- IL-1beta -RRB- mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages .
12706488	0	IL-1beta	50,58	interleukin-1beta	26,43	IL-1beta	interleukin-1beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study between interleukin-1beta gene -LRB- IL-1beta -RRB- and schizophrenia .
18541658	0	IL-1beta	22,30	interleukin-1beta	3,20	IL-1beta	interleukin-1beta	3553	3553	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	An interleukin-1beta -LRB- IL-1beta -RRB- single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues .
9482809	0	IL-1beta	52,60	interleukin-1beta	33,50	IL-1beta	interleukin-1beta	24494(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Vagotomy_blocks the induction of interleukin-1beta -LRB- IL-1beta -RRB- mRNA in the brain of rats in response to systemic_IL-1beta .
11422336	0	IL-1beta	51,59	interleukin_1_beta	31,49	IL-1beta	interleukin 1 beta	3553	3553	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Lack of association between an interleukin_1_beta -LRB- IL-1beta -RRB- gene variation and refractory temporal_lobe_epilepsy .
15304373	0	IL-1beta	41,49	leptin	69,75	IL-1beta	leptin	24494(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids : implications for energy homeostasis .
11554696	0	IL-1beta	10,18	oxytocin	31,39	IL-1beta	oxytocin	3553	5020	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of IL-1beta and IL-6 on oxytocin secretion in human uterine smooth muscle cells .
15195698	0	IL-1beta	19,27	p38_MAPK	0,8	IL-1beta	p38 MAPK	16176(Tax:10090)	26416(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p38_MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts .
10102472	0	IL-1beta	66,74	plasminogen_activator_inhibitor-1	18,51	IL-1beta	plasminogen activator inhibitor-1	3553	5054	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The activation of plasminogen_activator_inhibitor-1 expression by IL-1beta is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen_receptor_alpha .
17982107	0	IL-1beta	30,38	prostaglandin_endoperoxide_H_synthase_2	42,81	IL-1beta	prostaglandin endoperoxide H synthase 2	3553	5743	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Jak2 dampens the induction by IL-1beta of prostaglandin_endoperoxide_H_synthase_2 expression in human orbital fibroblasts : evidence for divergent influence on the prostaglandin_E2 biosynthetic pathway .
11104703	0	IL-1beta	38,46	signal_transducer_and_activator_of_transcription_factor_1	123,180	IL-1beta	signal transducer and activator of transcription factor 1	3553	6772	Gene	Gene	Cross-talk|nmod|START_ENTITY signalling|nsubj|Cross-talk signalling|parataxis|inhibits inhibits|dobj|END_ENTITY	Cross-talk between interleukin_1beta -LRB- IL-1beta -RRB- and IL-6 signalling pathways : IL-1beta selectively inhibits IL-6-activated signal_transducer_and_activator_of_transcription_factor_1 -LRB- STAT1 -RRB- by a proteasome-dependent mechanism .
11104703	0	IL-1beta	78,86	signal_transducer_and_activator_of_transcription_factor_1	123,180	IL-1beta	signal transducer and activator of transcription factor 1	3553	6772	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Cross-talk between interleukin_1beta -LRB- IL-1beta -RRB- and IL-6 signalling pathways : IL-1beta selectively inhibits IL-6-activated signal_transducer_and_activator_of_transcription_factor_1 -LRB- STAT1 -RRB- by a proteasome-dependent mechanism .
11758807	0	IL-1beta	0,8	uPA	19,22	IL-1beta	uPA	3553	5328	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	IL-1beta increases uPA and uPA receptor expression in human gingival fibroblasts .
18202522	0	IL-1beta	0,8	urokinase-type_plasminogen_activator	20,56	IL-1beta	urokinase-type plasminogen activator	3553	5328	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	IL-1beta stimulates urokinase-type_plasminogen_activator expression and secretion in human dental pulp cells .
18299313	0	IL-1ra	15,21	C-peptide	43,52	IL-1ra	C-peptide	3557	3630	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes .
19258032	0	IL-1ra	5,11	IL-1	0,4	IL-1ra	IL-1	16181(Tax:10090)	111343(Tax:10090)	Gene	Gene	balance|compound|START_ENTITY END_ENTITY|dep|balance	IL-1 / IL-1ra balance in the brain revisited - evidence from transgenic mouse models .
8777273	0	IL-1ra	50,56	IL-10	0,5	IL-1ra	IL-10	3557	3586	Gene	Gene	production|compound|START_ENTITY induce|dobj|production synergize|xcomp|induce synergize|nsubj|END_ENTITY	IL-10 and IL-4 synergize with TNF-alpha to induce IL-1ra production by human neutrophils .
18511291	0	IL-1ra	49,55	IL-1_beta	39,48	IL-1ra	IL-1 beta	3557	3553	Gene	Gene	ratio|compound|START_ENTITY ratio|dep|Pro-inflammatory Pro-inflammatory|dobj|disequilibrium disequilibrium|nmod|END_ENTITY	Pro-inflammatory disequilibrium of the IL-1_beta / IL-1ra ratio in an experimental model of perinatal brain_damages induced by lipopolysaccharide and hypoxia-ischemia .
7744786	1	IL-1ra	152,158	IL-1_beta	176,185	IL-1ra	IL-1 beta	3557	3553	Gene	Gene	site|nmod|START_ENTITY Identification|nmod|site Identification|nmod|END_ENTITY	Identification of a single site in IL-1ra and two sites in IL-1_beta .
7881833	0	IL-1ra	36,42	IL-1_beta	69,78	IL-1ra	IL-1 beta	3557	3553	Gene	Gene	IL-1_receptor_antagonist|appos|START_ENTITY IL-1_receptor_antagonist|dep|END_ENTITY	Increased IL-1_receptor_antagonist -LRB- IL-1ra -RRB- production and decreased IL-1_beta / IL-1ra ratio in mononuclear cells from rheumatoid_arthritis patients .
7881833	0	IL-1ra	79,85	IL-1_beta	69,78	IL-1ra	IL-1 beta	3557	3553	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Increased IL-1_receptor_antagonist -LRB- IL-1ra -RRB- production and decreased IL-1_beta / IL-1ra ratio in mononuclear cells from rheumatoid_arthritis patients .
8048540	0	IL-1ra	0,6	IL-1_beta	36,45	IL-1ra	IL-1 beta	3554	3553	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	IL-1ra suppresses endotoxin-induced IL-1_beta and TNF-alpha release from mononuclear phagocytes .
8277611	0	IL-1ra	87,93	IL-1_beta	47,56	IL-1ra	IL-1 beta	3557	3553	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|expression expression|nmod|END_ENTITY	-LSB- Quantitative evaluation of gene expression of IL-1_beta and IL-1_receptor_antagonist -LRB- IL-1ra -RRB- from alveolar_macrophages in idiopathic_pulmonary_fibrosis -LRB- IPF -RRB- and sarcoidosis -RSB- .
9292778	0	IL-1ra	89,95	IL-1_beta	41,50	IL-1ra	IL-1 beta	16181(Tax:10090)	16176(Tax:10090)	Gene	Gene	pattern|dep|START_ENTITY pattern|dep|END_ENTITY	Different pattern of interleukin-1_beta - -LRB- IL-1_beta -RRB- , interleukin-1_receptor_antagonist - -LRB- IL-1ra -RRB- and interleukin-1_receptor_type_I - -LRB- IL-1R_tI -RRB- mRNA-expression in single preimplantation mouse embryos at various developmental stages .
8786311	0	IL-1ra	26,32	IL-1_receptor_antagonist	0,24	IL-1ra	IL-1 receptor antagonist	16181(Tax:10090)	16181(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	IL-1_receptor_antagonist -LRB- IL-1ra -RRB- expression , function , and cytokine-mediated regulation during mycobacterial and schistosomal antigen-elicited granuloma formation .
20361987	0	IL-1ra	102,108	IL-1beta	65,73	IL-1ra	IL-1beta	60582(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII , and drives an overall anti-inflammatory phenotype in rat cortex .
12857678	0	IL-1ra	21,27	IL-6	0,4	IL-1ra	IL-6	3557	3569	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	IL-6 enhances plasma IL-1ra , IL-10 , and cortisol in humans .
22980031	0	IL-1ra	119,125	IL-6	12,16	IL-1ra	IL-6	16181(Tax:10090)	16193(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY autoimmune_disease|nmod|induction protects|nmod|autoimmune_disease protects|nsubj|treatment treatment|compound|END_ENTITY	Recombinant IL-6 treatment protects mice from organ specific autoimmune_disease by IL-6 classical signalling-dependent IL-1ra induction .
22980031	0	IL-1ra	119,125	IL-6	83,87	IL-1ra	IL-6	16181(Tax:10090)	16193(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Recombinant IL-6 treatment protects mice from organ specific autoimmune_disease by IL-6 classical signalling-dependent IL-1ra induction .
7908231	0	IL-1ra	76,82	Interleukin-13	0,14	IL-1ra	Interleukin-13	3557	3596	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-13 induces the production of interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- and the expression of the mRNA for the intracellular -LRB- keratinocyte -RRB- form of IL-1ra in human myelomonocytic cells .
7945810	0	IL-1ra	35,41	Interleukin-1_receptor_antagonist	0,33	IL-1ra	Interleukin-1 receptor antagonist	3557	3557	Gene	Gene	production|compound|START_ENTITY production|nummod|END_ENTITY	Interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- production by human amnion , chorion , and decidua .
9292778	0	IL-1ra	89,95	interleukin-1_beta	21,39	IL-1ra	interleukin-1 beta	16181(Tax:10090)	16176(Tax:10090)	Gene	Gene	pattern|dep|START_ENTITY pattern|nmod|END_ENTITY	Different pattern of interleukin-1_beta - -LRB- IL-1_beta -RRB- , interleukin-1_receptor_antagonist - -LRB- IL-1ra -RRB- and interleukin-1_receptor_type_I - -LRB- IL-1R_tI -RRB- mRNA-expression in single preimplantation mouse embryos at various developmental stages .
22827713	0	IL-1ra	88,94	interleukin-1_receptor_antagonist	53,86	IL-1ra	interleukin-1 receptor antagonist	60582(Tax:10116)	60582(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An experimental study on in situ transfection of the interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- gene into the rat cornea .
23723965	0	IL-1ra	98,104	interleukin-1_receptor_antagonist	63,96	IL-1ra	interleukin-1 receptor antagonist	60582(Tax:10116)	60582(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The experimental treatment of corneal graft rejection with the interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- gene .
9846481	0	IL-2	65,69	3BP2	57,61	IL-2	3BP2	3558	6452	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation .
15910743	0	IL-2	17,21	AICAR	0,5	IL-2	AICAR	3558	471	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells .
18769450	0	IL-2	14,18	BACH2	54,59	IL-2	BACH2	3558	60468	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of IL-2 expression by transcription factor BACH2 in umbilical cord blood CD4 + T cells .
17182561	0	IL-2	68,72	Blimp-1	19,26	IL-2	Blimp-1	3558	639	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|expression expression|compound|END_ENTITY	Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production .
22585398	0	IL-2	15,19	Blimp-1	79,86	IL-2	Blimp-1	3558	639	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|dep|repressing repressing|dobj|END_ENTITY	miR-9 enhances IL-2 production in activated human CD4 -LRB- + -RRB- T cells by repressing Blimp-1 .
25015830	0	IL-2	0,4	Blimp-1	18,25	IL-2	Blimp-1	3558	639	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	IL-2 induction of Blimp-1 is a key in vivo signal for CD8 + short-lived effector T cell differentiation .
21876034	0	IL-2	0,4	C-MAF	29,34	IL-2	C-MAF	3558	4094	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	IL-2 regulates expression of C-MAF in human CD4 T cells .
10201960	0	IL-2	88,92	CCR3	80,84	IL-2	CCR3	3558	1232	Gene	Gene	express|nmod|START_ENTITY express|dobj|END_ENTITY	Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 .
19553521	0	IL-2	0,4	CD103	15,20	IL-2	CD103	16183(Tax:10090)	16407(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	IL-2 regulates CD103 expression on CD4 + T cells in Scurfy mice that display both CD103-dependent and independent inflammation .
23126599	0	IL-2	83,87	CD103	31,36	IL-2	CD103	3558	3682	Gene	Gene	START_ENTITY|nsubj|induction induction|nmod|CD4 CD4|compound|END_ENTITY	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
19011158	0	IL-2	0,4	CD127	70,75	IL-2	CD127	3558	3575	Gene	Gene	cytokines|compound|START_ENTITY regulate|nsubj|cytokines regulate|dobj|+ +|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
10725703	0	IL-2	0,4	CD154	24,29	IL-2	CD154	3558	959	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nummod|END_ENTITY	IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells .
15153463	0	IL-2	14,18	CD25	77,81	IL-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|function function|compound|END_ENTITY	Cutting edge : IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function .
15470042	0	IL-2	116,120	CD25	11,15	IL-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene undergo|nmod|region fail|xcomp|undergo fail|nsubj|cells cells|compound|END_ENTITY	Murine CD4 + CD25 + regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene .
15770696	0	IL-2	57,61	CD25	83,87	IL-2	CD25	3558	3559	Gene	Gene	cells|amod|START_ENTITY cells|dep|help help|nmod|cells cells|compound|END_ENTITY	Activated CD1d-restricted natural killer T cells secrete IL-2 : innate help for CD4 + CD25 + regulatory T cells ?
16304057	0	IL-2	0,4	CD25	35,39	IL-2	CD25	3558	3559	Gene	Gene	administration|compound|START_ENTITY increases|nsubj|administration increases|dobj|Foxp3 Foxp3|compound|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
16645171	0	IL-2	0,4	CD25	45,49	IL-2	CD25	3558	3559	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
16887978	0	IL-2	69,73	CD25	110,114	IL-2	CD25	3558	3559	Gene	Gene	production|compound|START_ENTITY limits|dobj|production limits|nmod|cells cells|compound|END_ENTITY	Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4 + CD25 + regulatory T cells .
16917540	0	IL-2	14,18	CD25	55,59	IL-2	CD25	3558	3559	Gene	Gene	expansion|compound|START_ENTITY expansion|nmod|Tregs Tregs|compound|END_ENTITY	PTEN inhibits IL-2 receptor-mediated expansion of CD4 + CD25 + Tregs .
17015695	0	IL-2	26,30	CD25	88,92	IL-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	availability|nmod|START_ENTITY determinant|nsubj|availability determinant|acl|controlling controlling|dobj|production production|nmod|T T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17277105	0	IL-2	0,4	CD25	67,71	IL-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|xcomp|convert convert|dobj|CD25 CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17545278	0	IL-2	64,68	CD25	30,34	IL-2	CD25	3558	3559	Gene	Gene	potency|compound|START_ENTITY maintenance|dep|potency maintenance|nmod|function function|compound|END_ENTITY	The maintenance of human CD4 + CD25 + regulatory T cell function : IL-2 , IL-4 , IL-7 and IL-15 preserve optimal suppressive potency in vitro .
20081380	0	IL-2	24,28	CD25	64,68	IL-2	CD25	3558	3559	Gene	Gene	START_ENTITY|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20574434	0	IL-2	77,81	CD25	51,55	IL-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	enabled|nmod|START_ENTITY enabled|nsubjpass|regulation regulation|nmod|D3 D3|nmod|cells cells|compound|END_ENTITY	Gene regulation by 1,25-dihydroxyvitamin _ D3 in CD4 + CD25 + cells is enabled by IL-2 .
22984435	0	IL-2	104,108	CD25	28,32	IL-2	CD25	3558	3559	Gene	Gene	delivery|nmod|START_ENTITY vitro|nmod|delivery function|dep|vitro function|compound|END_ENTITY	Dendritic cells control CD4 + CD25 + Treg cell suppressor function in vitro through juxtacrine delivery of IL-2 .
27049955	0	IL-2	47,51	CD25	82,86	IL-2	CD25	3558	3559	Gene	Gene	Signaling|nmod|START_ENTITY Production|nsubj|Signaling Production|dep|Suppression Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
8069928	0	IL-2	59,63	CD25	220,224	IL-2	CD25	3558	3559	Gene	Gene	interleukin-10|appos|START_ENTITY interplay|nmod|interleukin-10 interplay|dep|synergizes synergizes|nmod|expression expression|amod|IL-2 IL-2|xcomp|enhance enhance|nmod|mechanism mechanism|acl:relcl|different different|nmod|upregulation upregulation|nmod|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
10092768	0	IL-2	86,90	CD28	57,61	IL-2	CD28	3558	940	Gene	Gene	promoter|compound|START_ENTITY element|nmod|promoter element|compound|END_ENTITY	The Jun_kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter : proof of cross-talk with the I kappa B kinase cascade .
10352279	0	IL-2	126,130	CD28	0,4	IL-2	CD28	3558	940	Gene	Gene	transactivation|compound|START_ENTITY enhancing|dobj|transactivation increasing|advcl|enhancing augments|advcl|increasing augments|nsubj|costimulation costimulation|compound|END_ENTITY	CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation .
10352279	0	IL-2	28,32	CD28	0,4	IL-2	CD28	3558	940	Gene	Gene	secretion|compound|START_ENTITY augments|dobj|secretion augments|nsubj|costimulation costimulation|compound|END_ENTITY	CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation .
10382746	0	IL-2	56,60	CD28	77,81	IL-2	CD28	3558	940	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nmod|pathway pathway|compound|END_ENTITY	Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway .
10760803	0	IL-2	86,90	CD28	0,4	IL-2	CD28	3558	940	Gene	Gene	mRNA|compound|START_ENTITY stabilizing|dobj|mRNA cyclosporin_A-resistant|advcl|stabilizing contribute|xcomp|cyclosporin_A-resistant contribute|nsubj|END_ENTITY	CD28 and LFA-1 contribute to cyclosporin_A-resistant T cell growth by stabilizing the IL-2 mRNA through distinct signaling pathways .
10882412	0	IL-2	56,60	CD28	8,12	IL-2	CD28	3558	940	Gene	Gene	chain|compound|START_ENTITY induced|nmod|chain IFN|parataxis|induced IFN|nsubj|Loss Loss|nmod|expression expression|nummod|END_ENTITY	Loss of CD28 expression on CD8 -LRB- + -RRB- T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN , and increases susceptibility to activation-induced apoptosis .
10898499	0	IL-2	18,22	CD28	37,41	IL-2	CD28	16183(Tax:10090)	12487(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Co-stimulation of IL-2 production by CD28 is independent of tyrosine-based signaling motifs in a murine T cell hybridoma .
11025487	0	IL-2	149,153	CD28	75,79	IL-2	CD28	3558	940	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|molecule molecule|compound|END_ENTITY	Alcoholic_liver_cirrhosis is associated with a decreased expression of the CD28 costimulatory molecule , a lower ability of T cells to bind exogenous IL-2 , and increased soluble CD8 levels .
11135576	0	IL-2	64,68	CD28	17,21	IL-2	CD28	16183(Tax:10090)	12487(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY signal|nmod|up-regulation signal|compound|END_ENTITY	Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines .
11587641	0	IL-2	94,98	CD28	69,73	IL-2	CD28	3558	940	Gene	Gene	element|nmod|START_ENTITY element|compound|END_ENTITY	X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2 .
11937538	0	IL-2	109,113	CD28	61,65	IL-2	CD28	16183(Tax:10090)	12487(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mechanisms|nmod|activation mechanisms|dobj|contribution contribution|nmod|END_ENTITY	Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation .
12444145	0	IL-2	56,60	CD28	51,55	IL-2	CD28	3558	940	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
12538664	0	IL-2	64,68	CD28	104,108	IL-2	CD28	3558	940	Gene	Gene	activation|compound|START_ENTITY activation|nmod|ligation ligation|nmod|END_ENTITY	A single amino_acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible_costimulator -LRB- ICOS -RRB- .
12963692	0	IL-2	99,103	CD28	15,19	IL-2	CD28	3558	940	Gene	Gene	production|compound|START_ENTITY reconstitutes|dobj|production effector|acl:relcl|reconstitutes Restoration|dep|effector Restoration|nmod|expression expression|nummod|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
12963692	0	IL-2	99,103	CD28	34,38	IL-2	CD28	3558	940	Gene	Gene	production|compound|START_ENTITY reconstitutes|dobj|production effector|acl:relcl|reconstitutes Restoration|dep|effector Restoration|nmod|expression expression|nmod|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
1380533	0	IL-2	30,34	CD28	4,8	IL-2	CD28	3558	940	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|ligand ligand|compound|END_ENTITY	The CD28 ligand , B7 , enhances IL-2 production by providing a costimulatory signal to T cells .
15280538	0	IL-2	58,62	CD28	17,21	IL-2	CD28	3558	940	Gene	Gene	Translocation|nmod|START_ENTITY Translocation|nmod|END_ENTITY	Translocation of CD28 to lipid rafts and costimulation of IL-2 .
15383581	0	IL-2	65,69	CD28	122,126	IL-2	CD28	3558	940	Gene	Gene	induction|compound|START_ENTITY costimulator|nmod|induction p75|nmod|costimulator role|nmod|p75 role|dep|link link|nmod|END_ENTITY	Critical role of TNF receptor type-2 -LRB- p75 -RRB- as a costimulator for IL-2 induction and T cell survival : a functional link to CD28 .
15710339	0	IL-2	122,126	CD28	79,83	IL-2	CD28	3558	940	Gene	Gene	expression|compound|START_ENTITY reduce|dobj|expression signaling|xcomp|reduce costimulatory|acl|signaling costimulatory|nummod|END_ENTITY	Cyclosporin_A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells .
15814687	0	IL-2	63,67	CD28	13,17	IL-2	CD28	3558	940	Gene	Gene	promoter|compound|START_ENTITY modification|nmod|promoter induce|dobj|modification induce|nsubj|Signals Signals|nmod|END_ENTITY	Signals from CD28 induce stable epigenetic modification of the IL-2 promoter .
16585571	0	IL-2	84,88	CD28	14,18	IL-2	CD28	3558	940	Gene	Gene	stability|compound|START_ENTITY up-regulation|nmod|stability results|nmod|up-regulation results|nsubj|Engagement Engagement|nmod|outside outside|nummod|END_ENTITY	Engagement of CD28 outside of the immunological synapse results in up-regulation of IL-2 mRNA stability but not IL-2 transcription .
1676547	0	IL-2	76,80	CD28	112,116	IL-2	CD28	3558	940	Gene	Gene	transcription|compound|START_ENTITY transcription|acl|mediated mediated|nmod|activation activation|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
1676547	0	IL-2	76,80	CD28	48,52	IL-2	CD28	3558	940	Gene	Gene	transcription|compound|START_ENTITY evidence|nmod|transcription Activation|dep|evidence Activation|nmod|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
1717561	0	IL-2	66,70	CD28	0,4	IL-2	CD28	3558	940	Gene	Gene	production|compound|START_ENTITY involved|nmod|production signal|acl|involved delivers|dobj|signal delivers|nsubj|END_ENTITY	CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells .
18025240	0	IL-2	126,130	CD28	84,88	IL-2	CD28	3558	940	Gene	Gene	substituted|nmod|START_ENTITY signal|acl:relcl|substituted signal|compound|END_ENTITY	Effective proliferation of human regulatory T cells requires a strong costimulatory CD28 signal that can not be substituted by IL-2 .
18097023	0	IL-2	36,40	CD28	116,120	IL-2	CD28	3558	940	Gene	Gene	mRNA|compound|START_ENTITY stabilize|dobj|mRNA export|acl|stabilize mediated|nsubjpass|export mediated|nmod|costimulation costimulation|compound|END_ENTITY	Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation .
2171783	0	IL-2	97,101	CD28	0,4	IL-2	CD28	3558	940	Gene	Gene	production|compound|START_ENTITY molecule|nmod|production molecule|nummod|END_ENTITY	CD28 molecule as a receptor-like function for accessory signals in cell-mediated augmentation of IL-2 production .
23851689	0	IL-2	65,69	CD28	34,38	IL-2	CD28	16183(Tax:10090)	12487(Tax:10090)	Gene	Gene	production|compound|START_ENTITY limiting|dobj|production enforces|advcl|limiting enforces|dobj|requirement requirement|nmod|costimulation costimulation|compound|END_ENTITY	Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production .
26500347	0	IL-2	17,21	CD28	41,45	IL-2	CD28	3558	940	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Costimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand .
7641692	0	IL-2	0,4	CD28	55,59	IL-2	CD28	3558	940	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	IL-2 gene expression and NF-kappa_B activation through CD28 requires reactive oxygen production by 5-lipoxygenase .
8946678	0	IL-2	119,123	CD28	61,65	IL-2	CD28	3558	940	Gene	Gene	secretion|compound|START_ENTITY required|nmod|secretion required|nsubjpass|Phosphorylation Phosphorylation|nmod|each each|nmod|tail tail|compound|END_ENTITY	Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28-induced T cell IL-2 secretion .
9199340	0	IL-2	65,69	CD28	0,4	IL-2	CD28	3558	940	Gene	Gene	promoter|appos|START_ENTITY upregulation|nmod|promoter mediates|dobj|upregulation mediates|nsubj|END_ENTITY	CD28 mediates transcriptional upregulation of the interleukin-2 -LRB- IL-2 -RRB- promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites .
9233628	0	IL-2	69,73	CD28	83,87	IL-2	CD28	16183(Tax:10090)	12487(Tax:10090)	Gene	Gene	element/AP|compound|START_ENTITY element/AP|compound|END_ENTITY	Involvement of Rel , Fos , and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP -1 sequence in human T cells .
9584155	0	IL-2	118,122	CD28	55,59	IL-2	CD28	3558	940	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|amod|responsible responsible|nmod|receptor receptor|dep|END_ENTITY	Mechanism responsible for T-cell antigen receptor - and CD28 - or interleukin_1 _ -LRB- IL-1 -RRB- receptor-initiated regulation of IL-2 gene expression by NF-kappaB .
9862666	0	IL-2	66,70	CD28	108,112	IL-2	CD28	3558	940	Gene	Gene	activation|compound|START_ENTITY activation|dep|requirement requirement|nmod|up-regulation up-regulation|nummod|END_ENTITY	Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation : requirement for CD28 up-regulation of RE/AP .
10337025	0	IL-2	51,55	CD4	24,27	IL-2	CD4	3558	920	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|T_lymphocytopenia T_lymphocytopenia|compound|END_ENTITY	Treatment of idiopathic CD4 T_lymphocytopenia with IL-2 .
10553070	0	IL-2	103,107	CD4	14,17	IL-2	CD4	3558	920	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter role|nmod|activation complexes|dep|role contain|dobj|complexes contain|nsubj|cells cells|compound|END_ENTITY	Primary human CD4 + T cells contain heterogeneous I kappa B kinase complexes : role in activation of the IL-2 promoter .
10570308	0	IL-2	87,91	CD4	44,47	IL-2	CD4	3558	920	Gene	Gene	amounts|nmod|START_ENTITY secreting|dobj|amounts cells|acl|secreting cells|compound|END_ENTITY	Prostaglandin_E2 selectively inhibits human CD4 + T cells secreting low amounts of both IL-2 and IL-4 .
10647875	0	IL-2	50,54	CD4	126,129	IL-2	CD4	3558	920	Gene	Gene	synthesis|nmod|START_ENTITY augment|dobj|synthesis ability|acl|augment associated|nsubjpass|ability associated|nmod|percentage percentage|nmod|cells cells|nummod|END_ENTITY	Thalidomide 's ability to augment the synthesis of IL-2 in vitro in HIV-infected patients is associated with the percentage of CD4 + cells in their blood .
10679063	0	IL-2	21,25	CD4	75,78	IL-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	IFN-alpha 2b reduces IL-2 production and IL-2_receptor function in primary CD4 + T cells .
10692234	0	IL-2	9,13	CD4	63,66	IL-2	CD4	3558	920	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|cells cells|amod|naive naive|dep|END_ENTITY	Low-dose IL-2 reduces lymphocyte apoptosis and increases naive CD4 cells in HIV-1 patients treated with HAART .
10725703	0	IL-2	0,4	CD4	54,57	IL-2	CD4	3558	920	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	IL-2 and IL-15 regulate CD154 expression on activated CD4 T cells .
10759770	0	IL-2	74,78	CD4	82,85	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Effects of therapy with highly active anti-retroviral therapy -LRB- HAART -RRB- and IL-2 on CD4 + and CD8 + lymphocyte apoptosis in HIV + patients .
10841521	0	IL-2	35,39	CD4	51,54	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	immunotherapy|nmod|START_ENTITY depends|nsubj|immunotherapy depends|nmod|T-cell T-cell|compound|END_ENTITY	Melanoma immunotherapy by targeted IL-2 depends on CD4 -LRB- + -RRB- T-cell help mediated by CD40/CD40L interaction .
11318602	0	IL-2	121,125	CD4	11,14	IL-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY responsive|nmod|therapy monoclonal|xcomp|responsive evolving|xcomp|monoclonal lymphocytopenia|acl|evolving lymphocytopenia|compound|END_ENTITY	Idiopathic CD4 + T cell lymphocytopenia evolving to monoclonal immunoglobulins and progressive renal_damage responsive to IL-2 therapy .
11363996	0	IL-2	0,4	CD4	35,38	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|appos|finds finds|dobj|increases increases|compound|END_ENTITY	IL-2 : controlled trial finds major CD4 increases .
11364361	0	IL-2	0,4	CD4	22,25	IL-2	CD4	3558	920	Gene	Gene	injections|compound|START_ENTITY boost|nsubj|injections boost|dobj|cells cells|nummod|END_ENTITY	IL-2 injections boost CD4 cells .
11366777	0	IL-2	13,17	CD4	63,66	IL-2	CD4	3558	920	Gene	Gene	years|nmod|START_ENTITY years|dep|fantastic_increases fantastic_increases|nmod|counts counts|compound|END_ENTITY	Two years of IL-2 in early HIV_disease -- fantastic_increases in CD4 + cell counts .
11579237	0	IL-2	92,96	CD4	0,3	IL-2	CD4	3558	920	Gene	Gene	cycles|compound|START_ENTITY associated|nmod|cycles associated|nsubjpass|expansions expansions|compound|END_ENTITY	CD4 T cell expansions are associated with increased apoptosis rates of T lymphocytes during IL-2 cycles in HIV_infected patients .
11685114	0	IL-2	51,55	CD4	91,94	IL-2	CD4	3558	920	Gene	Gene	region|compound|START_ENTITY region|nmod|T T|compound|END_ENTITY	Alterations in transcription factor binding at the IL-2 promoter region in anergized human CD4 + T lymphocytes .
11740186	0	IL-2	24,28	CD4	53,56	IL-2	CD4	708017(Tax:9544)	713807(Tax:9544)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus_macaques .
12149467	0	IL-2	67,71	CD4	40,43	IL-2	CD4	3558	920	Gene	Gene	treatment|compound|START_ENTITY +|nmod|treatment +|nsubj|expansion expansion|nmod|END_ENTITY	Increased peripheral expansion of naive CD4 + T cells in vivo after IL-2 treatment of patients with HIV_infection .
12444145	0	IL-2	56,60	CD4	62,65	IL-2	CD4	3558	920	Gene	Gene	responses|compound|START_ENTITY responses|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
12534941	0	IL-2	64,68	CD4	16,19	IL-2	CD4	116562(Tax:10116)	24932(Tax:10116)	Gene	Gene	confers|nsubj|START_ENTITY +|parataxis|confers +|nsubj|IL-4 IL-4|amod|responsive responsive|dep|END_ENTITY	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
12660531	0	IL-2	0,4	CD4	44,47	IL-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|cells cells|compound|END_ENTITY	IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia .
12660531	0	IL-2	0,4	CD4	93,96	IL-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|lymphopenia lymphopenia|compound|END_ENTITY	IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia .
12811838	0	IL-2	68,72	CD4	28,31	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	renders|compound|START_ENTITY activation|nmod|renders cells|amod|activation polarization|dep|cells polarization|nmod|cells cells|compound|END_ENTITY	`` Bystander polarization '' of CD4 + T cells : activation with high-dose IL-2 renders naive T cells responsive to IL-12 and/or IL-18 in the absence of TCR ligation .
12816995	0	IL-2	143,147	CD4	176,179	IL-2	CD4	3558	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase , Bcl-xL , and IL-2 expression in primary human CD4 T lymphocytes .
12847246	0	IL-2	20,24	CD4	87,90	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY _|nsubj|roles _|nmod|cells cells|compound|END_ENTITY	Regulatory roles of IL-2 and IL-4 in H4/inducible _ costimulator expression on activated CD4 + T cells during Th cell development .
12884288	0	IL-2	43,47	CD4	80,83	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|clones clones|compound|END_ENTITY	Analysis of allelic expression patterns of IL-2 , IL-3 , IL-4 , and IL-13 in human CD4 + T cell clones .
1346619	0	IL-2	46,50	CD4	23,26	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	producing|dobj|START_ENTITY precursor|acl|producing precursor|nmod|cells cells|compound|END_ENTITY	A common precursor for CD4 + T cells producing IL-2 or IL-4 .
1357032	0	IL-2	15,19	CD4	71,74	IL-2	CD4	3558	920	Gene	Gene	levels|nmod|START_ENTITY alter|nsubj|levels alter|dobj|transduction transduction|nmod|cells cells|compound|END_ENTITY	High levels of IL-2 alter signal transduction in cloned IL-4-producing CD4 T cells .
14512540	0	IL-2	124,128	CD4	66,69	IL-2	CD4	3558	920	Gene	Gene	interleukin-2|appos|START_ENTITY associated|nmod|interleukin-2 associated|nsubjpass|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Diminished proliferation of human_immunodeficiency_virus-specific CD4 + T cells is associated with diminished interleukin-2 -LRB- IL-2 -RRB- production and is recovered by exogenous IL-2 .
14734731	0	IL-2	56,60	CD4	0,3	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	generated|nmod|START_ENTITY generated|nsubj|+ +|compound|END_ENTITY	CD4 + and CD8 + regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a_lupus-like_syndrome .
15100259	0	IL-2	105,109	CD4	20,23	IL-2	CD4	3558	920	Gene	Gene	role|nmod|START_ENTITY cells|dep|role CD25|dep|cells educate|dobj|CD25 +|ccomp|educate +|nsubj|CD25 CD25|compound|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15100259	0	IL-2	105,109	CD4	44,47	IL-2	CD4	3558	920	Gene	Gene	role|nmod|START_ENTITY cells|dep|role CD25|dep|cells CD25|compound|END_ENTITY	Natural and induced CD4 + CD25 + cells educate CD4 + CD25 - cells to develop suppressive activity : the role of IL-2 , TGF-beta , and IL-10 .
15128800	0	IL-2	0,4	CD4	18,21	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|nummod|END_ENTITY	IL-2 secretion by CD4 + T cells in vivo is rapid , transient , and influenced by TCR-specific competition .
15153463	0	IL-2	14,18	CD4	73,76	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|function function|compound|END_ENTITY	Cutting edge : IL-2 is critically required for the in vitro activation of CD4 + CD25 + T cell suppressor function .
15214040	0	IL-2	119,123	CD4	0,3	IL-2	CD4	3558	920	Gene	Gene	secrete|nmod|START_ENTITY subset|acl:relcl|secrete IL-2Ralpha|acl:relcl|subset IL-2Ralpha|amod|END_ENTITY	CD4 -LRB- - -RRB- c-kit -LRB- - -RRB- CD3epsilon -LRB- - -RRB- IL-2Ralpha -LRB- + -RRB- Peyer 's patch cells are a novel cell subset which secrete IL-5 in response to IL-2 : implications for their role in IgA production .
15249725	0	IL-2	0,4	CD4	35,38	IL-2	CD4	3558	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	IL-2 and IL-10 production by human CD4 + T cells is differentially regulated by p38 : mode of stimulation-dependent regulation of IL-2 .
15249725	0	IL-2	127,131	CD4	35,38	IL-2	CD4	3558	920	Gene	Gene	regulation|nmod|START_ENTITY mode|nmod|regulation p38|dep|mode regulated|nmod|p38 regulated|nsubjpass|production production|nmod|cells cells|compound|END_ENTITY	IL-2 and IL-10 production by human CD4 + T cells is differentially regulated by p38 : mode of stimulation-dependent regulation of IL-2 .
15308379	0	IL-2	21,25	CD4	82,85	IL-2	CD4	708017(Tax:9544)	713807(Tax:9544)	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|END_ENTITY	IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus_macaques .
1531763	0	IL-2	82,86	CD4	39,42	IL-2	CD4	3558	920	Gene	Gene	pathway|compound|START_ENTITY precursors|nmod|pathway CD8|dep|precursors CD8|nummod|END_ENTITY	IL-7 induces proliferation of CD3 - / low CD4 - CD8 - human thymocyte precursors by an IL-2 independent pathway .
1533149	0	IL-2	111,115	CD4	39,42	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY role|nmod|secretion requirements|dep|role requirements|nmod|+ +|compound|END_ENTITY	Similar co-stimulation requirements of CD4 + and CD8 + primary T helper cells : role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation .
15359109	0	IL-2	21,25	CD4	63,66	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	administration|compound|START_ENTITY administration|nmod|homeostasis homeostasis|nmod|T T|compound|END_ENTITY	Effects of exogenous IL-2 administration on the homeostasis of CD4 + T lymphocytes .
15470042	0	IL-2	116,120	CD4	7,10	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene undergo|nmod|region fail|xcomp|undergo fail|nsubj|cells cells|compound|END_ENTITY	Murine CD4 + CD25 + regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene .
15611237	0	IL-2	14,18	CD4	66,69	IL-2	CD4	3558	920	Gene	Gene	Uncoupling|nmod|START_ENTITY Uncoupling|acl|signaling signaling|nmod|progression progression|nmod|cells cells|compound|END_ENTITY	Uncoupling of IL-2 signaling from cell cycle progression in naive CD4 + T cells by regulatory CD4 + CD25 + T lymphocytes .
15611237	0	IL-2	14,18	CD4	93,96	IL-2	CD4	3558	920	Gene	Gene	Uncoupling|nmod|START_ENTITY Uncoupling|acl|signaling signaling|nmod|T T|compound|END_ENTITY	Uncoupling of IL-2 signaling from cell cycle progression in naive CD4 + T cells by regulatory CD4 + CD25 + T lymphocytes .
15678692	0	IL-2	17,21	CD4	75,78	IL-2	CD4	3558	920	Gene	Gene	Dysregulation|nmod|START_ENTITY Dysregulation|parataxis|alters alters|dobj|proliferation proliferation|nmod|subset subset|compound|END_ENTITY	Dysregulation of IL-2 / IL-2R system alters proliferation of early activated CD4 + T cell subset in patients with end-stage_renal_failure .
15682445	0	IL-2	93,97	CD4	33,36	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|homeostasis homeostasis|nummod|END_ENTITY	CD40/CD40L interaction regulates CD4 + CD25 + T reg homeostasis through dendritic cell-produced IL-2 .
15684039	0	IL-2	55,59	CD4	38,41	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	compete|nmod|START_ENTITY compete|nmod|cells cells|compound|END_ENTITY	CD25 + CD4 + T cells compete with naive CD4 + T cells for IL-2 and exploit it for the induction of IL-10 production .
15684039	0	IL-2	55,59	CD4	6,9	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	compete|nmod|START_ENTITY +|ccomp|compete +|nsubj|END_ENTITY	CD25 + CD4 + T cells compete with naive CD4 + T cells for IL-2 and exploit it for the induction of IL-10 production .
15753206	0	IL-2	139,143	CD4	52,55	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	neutralization|compound|START_ENTITY regulatory|nmod|neutralization regulatory|nsubj|maintenance maintenance|nmod|END_ENTITY	Homeostatic maintenance of natural Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells by interleukin _ -LRB- IL -RRB- -2 and induction of autoimmune_disease by IL-2 neutralization .
15770696	0	IL-2	57,61	CD4	79,82	IL-2	CD4	3558	920	Gene	Gene	cells|amod|START_ENTITY cells|dep|help help|nmod|cells cells|compound|END_ENTITY	Activated CD1d-restricted natural killer T cells secrete IL-2 : innate help for CD4 + CD25 + regulatory T cells ?
15814700	0	IL-2	89,93	CD4	123,126	IL-2	CD4	3558	713807(Tax:9544)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Dysfunction of simian_immunodeficiency_virus / simian_human_immunodeficiency_virus-induced IL-2 expression by central memory CD4 + T lymphocytes .
15944195	0	IL-2	40,44	CD4	104,107	IL-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY modulate|dobj|production modulate|nmod|cells cells|compound|END_ENTITY	DC-SIGN , but not sDC-SIGN , can modulate IL-2 production from PMA - and anti-CD3-stimulated primary human CD4 T cells .
16025158	0	IL-2	70,74	CD4	35,38	IL-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY lymphocytes|nmod|therapy lymphocytes|nsubj|Induction Induction|nmod|survival survival|nmod|T T|compound|END_ENTITY	Induction of prolonged survival of CD4 + T lymphocytes by intermittent IL-2 therapy in HIV-infected patients .
16037071	0	IL-2	0,4	CD4	23,26	IL-2	CD4	3558	920	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-2 responsiveness of CD4 and CD8 lymphocytes : further investigations with human IL-2Rbeta transgenic_mice .
16304057	0	IL-2	0,4	CD4	30,33	IL-2	CD4	3558	920	Gene	Gene	administration|compound|START_ENTITY increases|nsubj|administration increases|dobj|Foxp3 Foxp3|compound|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
16456009	0	IL-2	100,104	CD4	17,20	IL-2	CD4	3558	920	Gene	Gene	inhibition|compound|START_ENTITY enhances|nmod|inhibition enhances|nsubj|ligation ligation|nmod|cells cells|compound|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16624934	0	IL-2	142,146	CD4	72,75	IL-2	CD4	3558	920	Gene	Gene	role|nmod|START_ENTITY depends|dobj|role depends|nsubj|interactions interactions|nmod|cells cells|compound|END_ENTITY	Modulation of cell cycle progression by CTLA4-CD80 / CD86 interactions on CD4 + T cells depends on strength of the CD3 signal : critical role for IL-2 .
16637008	0	IL-2	45,49	CD4	14,17	IL-2	CD4	16183(Tax:10090)	920	Gene	Gene	require|dobj|START_ENTITY require|nsubj|cells cells|compound|END_ENTITY	LACK-reactive CD4 + T cells require autocrine IL-2 to mediate susceptibility to Leishmania_major .
16645171	0	IL-2	0,4	CD4	41,44	IL-2	CD4	3558	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
1674955	0	IL-2	14,18	CD4	103,106	IL-2	CD4	3558	920	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|chain chain|nmod|cells cells|nummod|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
1677670	0	IL-2	24,28	CD4	43,46	IL-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY Induction|nmod|production Induction|nmod|END_ENTITY	Induction of high level IL-2 production in CD4 +8 - T helper lymphocytes requires post-thymic development .
16818762	0	IL-2	29,33	CD4	92,95	IL-2	CD4	3558	920	Gene	Gene	remodeling|nmod|START_ENTITY influenced|nsubjpass|remodeling influenced|nmod|cells cells|compound|END_ENTITY	Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells .
16887978	0	IL-2	69,73	CD4	106,109	IL-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY limits|dobj|production limits|nmod|cells cells|compound|END_ENTITY	Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4 + CD25 + regulatory T cells .
16917540	0	IL-2	14,18	CD4	50,53	IL-2	CD4	3558	920	Gene	Gene	expansion|compound|START_ENTITY expansion|nmod|Tregs Tregs|compound|END_ENTITY	PTEN inhibits IL-2 receptor-mediated expansion of CD4 + CD25 + Tregs .
16982857	0	IL-2	44,48	CD4	95,98	IL-2	CD4	3558	920	Gene	Gene	signaling|compound|START_ENTITY sustained|nsubjpass|signaling sustained|nmod|response response|compound|END_ENTITY	Cutting edge : Paracrine , but not autocrine , IL-2 signaling is sustained during early antiviral CD4 T cell response .
16987710	0	IL-2	40,44	CD4	24,27	IL-2	CD4	3558	920	Gene	Gene	expression|compound|START_ENTITY +|dep|expression +|compound|END_ENTITY	Normalized CD8 + but not CD4 + lymphocyte IL-2 expression is associated with early treatment with highly active antiretroviral therapy .
17015695	0	IL-2	26,30	CD4	84,87	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	availability|nmod|START_ENTITY determinant|nsubj|availability determinant|acl|controlling controlling|dobj|production production|nmod|T T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
1703048	0	IL-2	241,245	CD4	17,20	IL-2	CD4	116562(Tax:10116)	24932(Tax:10116)	Gene	Gene	presence|nmod|START_ENTITY IFN|nmod|presence producers|nmod|IFN have|advcl|producers CD45RB|parataxis|have defined|dep|CD45RB subsets|dep|defined subsets|nsubj|Functions Functions|nmod|cell cell|compound|END_ENTITY	Functions of rat CD4 + T cell subsets defined by CD45RB : CD45RB - cells have a much stronger response to recall antigens , whereas polyclonally activated cells of both subsets are equally efficient producers of IFN in the presence of exogenous IL-2 .
17277105	0	IL-2	0,4	CD4	48,51	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|xcomp|convert convert|dobj|CD25 CD25|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17411376	0	IL-2	88,92	CD4	113,116	IL-2	CD4	3558	920	Gene	Gene	CD8|compound|START_ENTITY CD8|dep|+ +|compound|END_ENTITY	HLA-DR-restricted peptides identified in the Nef protein can induce HIV_type_1-specific IL-2 / IFN-gamma-secreting CD4 + and CD4 + / CD8 + T cells in humans after lipopeptide vaccination .
17545278	0	IL-2	64,68	CD4	25,28	IL-2	CD4	3558	920	Gene	Gene	potency|compound|START_ENTITY maintenance|dep|potency maintenance|nmod|function function|compound|END_ENTITY	The maintenance of human CD4 + CD25 + regulatory T cell function : IL-2 , IL-4 , IL-7 and IL-15 preserve optimal suppressive potency in vitro .
17548609	0	IL-2	190,194	CD4	0,3	IL-2	CD4	3558	920	Gene	Gene	promoter|compound|START_ENTITY produce|nmod|promoter produce|nsubj|cells cells|nummod|END_ENTITY	CD4 + T cells from simian_immunodeficiency_virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species : involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation .
17548609	0	IL-2	207,211	CD4	0,3	IL-2	CD4	3558	920	Gene	Gene	up-regulation|compound|START_ENTITY promoter|nmod|up-regulation produce|nmod|promoter produce|nsubj|cells cells|nummod|END_ENTITY	CD4 + T cells from simian_immunodeficiency_virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species : involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation .
17548609	0	IL-2	95,99	CD4	0,3	IL-2	CD4	3558	920	Gene	Gene	produce|xcomp|START_ENTITY produce|nsubj|cells cells|nummod|END_ENTITY	CD4 + T cells from simian_immunodeficiency_virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species : involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation .
17617586	0	IL-2	0,4	CD4	28,31	IL-2	CD4	3558	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expansion expansion|nmod|populations populations|compound|END_ENTITY	IL-2 regulates expansion of CD4 + T cell populations by affecting cell death : insights from modeling CFSE data .
18273057	0	IL-2	8,12	CD4	40,43	IL-2	CD4	3558	920	Gene	Gene	Role|nmod|START_ENTITY secreted|nsubj|Role secreted|nmod|cells cells|compound|END_ENTITY	Role of IL-2 secreted by PADRE-specific CD4 + T cells in enhancing E7-specific CD8 + T-cell immune responses .
18395858	0	IL-2	17,21	CD4	86,89	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|Treg Treg|compound|END_ENTITY	Critical role of IL-2 and TGF-beta in generation , function and stabilization of Foxp3 + CD4 + Treg .
18471351	0	IL-2	40,44	CD4	68,71	IL-2	CD4	116562(Tax:10116)	24932(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Implication of different expression of IL-2 mRNA and IL-10 mRNA in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cell induced immune tolerance of liver transplantation in rat -RSB- .
18490709	0	IL-2	60,64	CD4	20,23	IL-2	CD4	3558	920	Gene	Gene	induced|nmod|START_ENTITY cells|acl|induced resistant|nsubj|cells +|ccomp|resistant +|nsubj|CD25 CD25|compound|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18493984	0	IL-2	0,4	CD4	36,39	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|dep|START_ENTITY induces|nmod|suppression suppression|nmod|CD25 CD25|compound|END_ENTITY	IL-2 induces in vivo suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18714004	0	IL-2	53,57	CD4	29,32	IL-2	CD4	3558	920	Gene	Gene	T|amod|START_ENTITY responses|nmod|T lymphocytes|nsubj|responses lymphocytes|nmod|suppression suppression|nmod|T T|compound|END_ENTITY	In vivo suppression of naive CD4 T cell responses by IL-2 - and antigen-stimulated T lymphocytes in the absence of APC competition .
18714042	0	IL-2	0,4	CD4	22,25	IL-2	CD4	3558	920	Gene	Gene	memory|compound|START_ENTITY memory|acl:relcl|lymphocytes lymphocytes|nsubj|T T|compound|END_ENTITY	IL-2 producing memory CD4 + T lymphocytes are closely associated with the generation of IgG-secreting plasma cells .
18827184	0	IL-2	43,47	CD4	0,3	IL-2	CD4	3558	920	Gene	Gene	alloactivated|nmod|START_ENTITY alloactivated|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + CD25 + T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes , suggesting separate pathways of activation by Th1 and Th2 responses .
18941219	0	IL-2	21,25	CD4	46,49	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	variants|compound|START_ENTITY variants|nmod|cell cell|compound|END_ENTITY	Impact of protective IL-2 allelic variants on CD4 + Foxp3 + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice .
19050236	0	IL-2	72,76	CD4	96,99	IL-2	CD4	3558	920	Gene	Gene	secretion|compound|START_ENTITY regulating|dobj|secretion regulating|nmod|memory memory|compound|END_ENTITY	Cutting edge : a T-bet-independent role for IFN-alpha/beta in regulating IL-2 secretion in human CD4 + central memory T cells .
19098490	0	IL-2	15,19	CD4	64,67	IL-2	CD4	3558	920	Gene	Gene	Inferiority|nmod|START_ENTITY versus|nsubj|Inferiority versus|nmod|trial trial|dep|maintaining maintaining|dobj|counts counts|compound|END_ENTITY	Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption : a randomized controlled trial .
19098490	0	IL-2	33,37	CD4	64,67	IL-2	CD4	3558	920	Gene	Gene	versus|dobj|START_ENTITY versus|nmod|trial trial|dep|maintaining maintaining|dobj|counts counts|compound|END_ENTITY	Inferiority of IL-2 alone versus IL-2 with HAART in maintaining CD4 T cell counts during HAART interruption : a randomized controlled trial .
19522766	0	IL-2	101,105	CD4	41,44	IL-2	CD4	3558	920	Gene	Gene	action|nmod|START_ENTITY inhibit|dobj|action inhibit|nsubj|CD25 CD25|acl|shedding shedding|advcl|occurring occurring|dobj|cells cells|nummod|END_ENTITY	CD25 shedding by human natural occurring CD4 + CD25 + regulatory T cells does not inhibit the action of IL-2 .
19553521	0	IL-2	0,4	CD4	35,38	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|nummod|END_ENTITY	IL-2 regulates CD103 expression on CD4 + T cells in Scurfy mice that display both CD103-dependent and independent inflammation .
19654878	0	IL-2	85,89	CD4	13,16	IL-2	CD4	3558	920	Gene	Gene	deprivation|compound|START_ENTITY mediated|nmod|deprivation T|ccomp|mediated T|nsubj|Apoptosis Apoptosis|nmod|CD25 CD25|compound|END_ENTITY	Apoptosis of CD4 + CD25 -LRB- high -RRB- T cells in type 1 diabetes may be partially mediated by IL-2 deprivation .
1968430	0	IL-2	33,37	CD4	65,68	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	IL-4|compound|START_ENTITY IL-4|nmod|populations populations|compound|END_ENTITY	Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4 + populations .
1972141	0	IL-2	8,12	CD4	80,83	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|growth growth|nmod|helper helper|compound|END_ENTITY	Role of IL-2 , IL-4 and IL-6 in the growth and differentiation of tumor-specific CD4 + T helper and CD8 + T cytotoxic cells .
19878686	0	IL-2	21,25	CD4	51,54	IL-2	CD4	3558	920	Gene	Gene	role|nmod|START_ENTITY Modeling|dobj|role Modeling|nmod|interplay interplay|nmod|helper helper|nummod|+ +|compound|END_ENTITY	Modeling the role of IL-2 in the interplay between CD4 + helper and regulatory T cells : assessing general dynamical properties .
19950184	0	IL-2	20,24	CD4	66,69	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|expansion expansion|nmod|T T|compound|END_ENTITY	IL-7 is superior to IL-2 for ex vivo expansion of tumour-specific CD4 -LRB- + -RRB- T cells .
20081380	0	IL-2	24,28	CD4	59,62	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
20137305	0	IL-2	35,39	CD4	77,80	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|dep|START_ENTITY induces|dobj|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Combination of dexamethasone with IL-2 selectively induces the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft versus host disease . -RSB- .
20561440	0	IL-2	56,60	CD4	22,25	IL-2	CD4	3558	920	Gene	Gene	cells|amod|START_ENTITY CD25|dep|cells CD25|compound|END_ENTITY	-LSB- Relationship between CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , IL-2 , TGF-beta and acute_graft-versus_host_disease after allogeneic hematopoietic stem cell transplantation -RSB- .
20571894	0	IL-2	0,4	CD4	95,98	IL-2	CD4	3558	920	Gene	Gene	maintains|dep|START_ENTITY maintains|nsubj|numbers numbers|nmod|IL-17 IL-17|acl|expressing expressing|dobj|cells cells|compound|END_ENTITY	IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4 + T -LRB- T -LRB- H -RRB- 17 -RRB- cells in the periphery .
20574434	0	IL-2	77,81	CD4	47,50	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	enabled|nmod|START_ENTITY enabled|nsubjpass|regulation regulation|nmod|D3 D3|nmod|cells cells|compound|END_ENTITY	Gene regulation by 1,25-dihydroxyvitamin _ D3 in CD4 + CD25 + cells is enabled by IL-2 .
20623548	0	IL-2	0,4	CD4	62,65	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|development development|nmod|cells cells|compound|END_ENTITY	IL-2 is positively involved in the development of colitogenic CD4 + IL-7R_alpha high memory T cells in chronic_colitis .
20702463	0	IL-2	0,4	CD4	38,41	IL-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY therapy|dep|impact impact|nmod|count count|compound|END_ENTITY	IL-2 therapy : potential impact of the CD4 cell count at initiation on clinical efficacy -- results from the ANRS CO4 cohort .
20856822	0	IL-2	0,4	CD4	14,17	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|help help|compound|END_ENTITY	IL-2 mediates CD4 + T cell help in the breakdown of memory-like CD8 + T cell tolerance under lymphopenic conditions .
21059770	0	IL-2	73,77	CD4	23,26	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|Production Production|nmod|cells cells|amod|IFN-y IFN-y|nmod|T T|compound|END_ENTITY	Production of IFN-y by CD4 -LRB- + -RRB- T cells in response to malaria antigens is IL-2 dependent .
21107839	0	IL-2	112,116	CD4	63,66	IL-2	CD4	3558	920	Gene	Gene	cytokines|dep|START_ENTITY using|dobj|cytokines cells|acl|using cells|dep|cells cells|nmod|END_ENTITY	Expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from cord blood CD4 -LRB- + -RRB- cells using the common y-chain cytokines -LRB- IL-2 and IL-15 -RRB- and rapamycin .
21112091	0	IL-2	46,50	CD4	16,19	IL-2	CD4	3558	920	Gene	Gene	expression|compound|START_ENTITY lymphocytes|dobj|expression lymphocytes|nsubj|T T|compound|END_ENTITY	Human activated CD4 -LRB- + -RRB- T lymphocytes increase IL-2 expression by downregulating microRNA-181c .
21350367	0	IL-2	27,31	CD4	43,46	IL-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|cells cells|compound|END_ENTITY	The effect of intermittent IL-2 therapy on CD4 T cells in the gut in HIV-1-infected patients .
21389253	0	IL-2	0,4	CD4	50,53	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|advcl|maintaining maintaining|dobj|balance balance|nmod|cells cells|compound|END_ENTITY	IL-2 contributes to maintaining a balance between CD4 + Foxp3 + regulatory T cells and effector CD4 + T cells required for immune control of blood-stage malaria_infection .
21469091	0	IL-2	8,12	CD4	83,86	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY leads|nsubj|expression leads|nmod|increase increase|nmod|cells cells|compound|END_ENTITY	Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3 + CD4 + T cells with limited suppressor activity .
21502514	0	IL-2	88,92	CD4	0,3	IL-2	CD4	3558	920	Gene	Gene	homeostasis|compound|START_ENTITY differentiation|nmod|homeostasis control|dobj|differentiation control|nsubj|cells cells|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasis .
21876034	0	IL-2	0,4	CD4	44,47	IL-2	CD4	3558	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|compound|END_ENTITY	IL-2 regulates expression of C-MAF in human CD4 T cells .
22216206	0	IL-2	37,41	CD4	66,69	IL-2	CD4	280822(Tax:9913)	407098(Tax:9913)	Gene	Gene	antibody|nmod|START_ENTITY Development|nmod|antibody reveals|nsubj|Development reveals|dobj|cells cells|compound|END_ENTITY	Development of an antibody to bovine IL-2 reveals multifunctional CD4 T -LRB- EM -RRB- cells in cattle naturally infected with bovine_tuberculosis .
22246628	0	IL-2	0,4	CD4	42,45	IL-2	CD4	3558	920	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	IL-2 upregulates CD86 expression on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
22276195	0	IL-2	114,118	CD4	28,31	IL-2	CD4	3558	920	Gene	Gene	administration|compound|START_ENTITY +|nmod|administration +|nmod|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22461525	0	IL-2	47,51	CD4	80,83	IL-2	CD4	3558	920	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|cells cells|amod|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
22516956	0	IL-2	114,118	CD4	163,166	IL-2	CD4	3558	920	Gene	Gene	receptor|compound|START_ENTITY partial|nmod|receptor cells|nmod|partial expansion|nmod|cells expansion|dep|role role|nmod|cells cells|compound|END_ENTITY	Preferential expansion of human virus-specific multifunctional central memory T cells by partial targeting of the IL-2 receptor signaling pathway : the key role of CD4 + T cells .
22585398	0	IL-2	15,19	CD4	50,53	IL-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nmod|END_ENTITY	miR-9 enhances IL-2 production in activated human CD4 -LRB- + -RRB- T cells by repressing Blimp-1 .
22682297	0	IL-2	9,13	CD4	39,42	IL-2	CD4	3558	920	Gene	Gene	+|nsubj|START_ENTITY +|nmod|expansion expansion|nmod|+ +|compound|END_ENTITY	Low-dose IL-2 for In vivo expansion of CD4 + and CD8 + regulatory T cells in nonhuman primates .
22984435	0	IL-2	104,108	CD4	24,27	IL-2	CD4	3558	920	Gene	Gene	delivery|nmod|START_ENTITY vitro|nmod|delivery function|dep|vitro function|compound|END_ENTITY	Dendritic cells control CD4 + CD25 + Treg cell suppressor function in vitro through juxtacrine delivery of IL-2 .
23126599	0	IL-2	83,87	CD4	56,59	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|nsubj|induction induction|nmod|END_ENTITY	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
23418630	0	IL-2	98,102	CD4	30,33	IL-2	CD4	3558	920	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors defined|nmod|expression defined|nsubj|expansion expansion|nmod|cells cells|compound|END_ENTITY	Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors .
23526940	0	IL-2	19,23	CD4	49,52	IL-2	CD4	3558	920	Gene	Gene	cells|amod|START_ENTITY Increase|nmod|cells Increase|nmod|responses responses|compound|END_ENTITY	Increase in IFNy -LRB- - -RRB- IL-2 -LRB- + -RRB- cells in recent human CD4 T cell responses to 2009 pandemic H1N1 influenza .
24281729	0	IL-2	18,22	CD4	35,38	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of IL-2 and IL-4 in CD4 -LRB- + -RRB- T cells from mouse lymph nodes and spleen during HSV-1-induced facial_palsy .
24291244	0	IL-2	28,32	CD4	45,48	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	Promoter|compound|START_ENTITY Promoter|nmod|cells cells|compound|END_ENTITY	Active demethylation of the IL-2 Promoter in CD4 + T cells is mediated by an inducible DNA glycosylase , Myh .
24586481	0	IL-2	22,26	CD4	63,66	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	driven|amod|START_ENTITY differentiation|amod|driven differentiation|nmod|cells cells|compound|END_ENTITY	Inflammation enhances IL-2 driven differentiation of cytolytic CD4 T cells .
24587342	0	IL-2	41,45	CD4	55,58	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells .
24989679	0	IL-2	0,4	CD4	33,36	IL-2	CD4	3558	920	Gene	Gene	Inhibited|dep|START_ENTITY Inhibited|dobj|Generation Generation|nmod|Memory Memory|compound|END_ENTITY	IL-2 Inhibited the Generation of CD4 -LRB- + -RRB- Memory T Cells .
2523423	0	IL-2	8,12	CD4	34,37	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|+ +|compound|END_ENTITY	Role of IL-2 in the generation of CD4 + suppressors of human B cell responsiveness .
2523864	0	IL-2	145,149	CD4	160,163	IL-2	CD4	3558	920	Gene	Gene	START_ENTITY|acl|activated activated|dobj|R R|nummod|+45 +45|compound|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	IL-2	145,149	CD4	23,26	IL-2	CD4	3558	920	Gene	Gene	restricted|nmod|START_ENTITY promoted|advcl|restricted T|parataxis|promoted T|nsubj|Proliferation Proliferation|nmod|+ +|compound|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	IL-2	80,84	CD4	160,163	IL-2	CD4	3558	920	Gene	Gene	promoted|nmod|START_ENTITY promoted|advcl|restricted restricted|nmod|IL-2 IL-2|acl|activated activated|dobj|R R|nummod|+45 +45|compound|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	IL-2	80,84	CD4	23,26	IL-2	CD4	3558	920	Gene	Gene	promoted|nmod|START_ENTITY T|parataxis|promoted T|nsubj|Proliferation Proliferation|nmod|+ +|compound|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
25369785	0	IL-2	98,102	CD4	9,12	IL-2	CD4	3558	920	Gene	Gene	induce|dobj|START_ENTITY interactions|acl:relcl|induce requires|dobj|interactions requires|nsubj|transition transition|compound|END_ENTITY	Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2 .
25491339	0	IL-2	15,19	CD4	52,55	IL-2	CD4	3558	920	Gene	Gene	Production|compound|START_ENTITY Suppression|nmod|Production Suppression|nmod|T T|compound|END_ENTITY	Suppression of IL-2 Production and Proliferation of CD4 -LRB- + -RRB- T Cells by Tuberostemonine O. Tuberostemonine stereoisomers are natural alkaloids found in Stemona tuberosa , that are known to have anti-inflammatory and anti-infective properties .
25578385	0	IL-2	46,50	CD4	102,105	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nmod|T T|compound|END_ENTITY	Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-y production by Toxoplasma_gondii-reactive CD4 -LRB- + -RRB- T cells .
2568977	0	IL-2	0,4	CD4	79,82	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	co-modulate|nsubj|START_ENTITY co-modulate|nmod|CD8 CD8|dep|END_ENTITY	IL-2 and IL-4 can co-modulate the generation of cytotoxic T cells through CD8 - CD4 - splenic lymphocytes .
2572284	0	IL-2	99,103	CD4	161,164	IL-2	CD4	3558	920	Gene	Gene	interleukin-2|appos|START_ENTITY synthesize|dobj|interleukin-2 synthesize|nmod|END_ENTITY	T-cell ontogeny after autologous bone marrow transplantation : failure to synthesize interleukin-2 -LRB- IL-2 -RRB- and lack of CD2 - and CD3-mediated proliferation by both CD4 - and CD8 + cells even in the presence of exogeneous IL-2 .
26062998	0	IL-2	79,83	CD4	107,110	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Role|nmod|Production Plays|dobj|Role Plays|nmod|Cells Cells|compound|END_ENTITY	Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4 + Conventional T Cells .
26320249	0	IL-2	42,46	CD4	31,34	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	Severity|compound|START_ENTITY Severity|compound|END_ENTITY	Intrinsic Differences in Donor CD4 T Cell IL-2 Production Influence Severity of Parent-into-F1 Murine Lupus by Skewing the Immune Response Either toward Help for B Cells and a Sustained Autoantibody Response or toward Help for CD8 T Cells and a Downregulatory Th1 Response .
26886923	0	IL-2	99,103	CD4	50,53	IL-2	CD4	3558	920	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|Cells Cells|compound|END_ENTITY	Comparative Analysis of Protocols to Induce Human CD4 + Foxp3 + Regulatory T Cells by Combinations of IL-2 , TGF-beta , Retinoic_Acid , Rapamycin and Butyrate .
27049955	0	IL-2	47,51	CD4	78,81	IL-2	CD4	3558	920	Gene	Gene	Signaling|nmod|START_ENTITY Production|nsubj|Signaling Production|dep|Suppression Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
27053558	0	IL-2	0,4	CD4	21,24	IL-2	CD4	3558	920	Gene	Gene	Therapy|compound|START_ENTITY Induces|nsubj|Therapy Induces|dobj|Regulation Regulation|compound|END_ENTITY	IL-2 Therapy Induces CD4 Down Regulation in African_Green_Monkeys which Decreases Circulating CD4 T Cell Counts .
27053558	0	IL-2	0,4	CD4	94,97	IL-2	CD4	3558	920	Gene	Gene	Therapy|compound|START_ENTITY Induces|nsubj|Therapy Induces|dobj|Regulation Regulation|acl:relcl|Counts Counts|nsubj|Cell Cell|compound|END_ENTITY	IL-2 Therapy Induces CD4 Down Regulation in African_Green_Monkeys which Decreases Circulating CD4 T Cell Counts .
2969394	0	IL-2	27,31	CD4	72,75	IL-2	CD4	3558	920	Gene	Gene	production|nmod|START_ENTITY Simultaneous|dobj|production Simultaneous|nmod|+ +|compound|END_ENTITY	Simultaneous production of IL-2 , IL-4 , and IFN-gamma by activated human CD4 + and CD8 + T cell clones .
2972776	0	IL-2	36,40	CD4	13,16	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|xcomp|START_ENTITY +8|parataxis|produce +8|compound|END_ENTITY	Athymic nude CD4 +8 - T cells produce IL-2 but fail to proliferate in response to mitogenic stimuli .
2976621	0	IL-2	23,27	CD4	77,80	IL-2	CD4	3558	920	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|cells cells|compound|END_ENTITY	Nickel antigen induces IL-2 secretion and IL-2_receptor expression mainly on CD4 + T cells , but no measurable gamma interferon secretion in peripheral blood mononuclear cell cultures in delayed type hypersensitivity to nickel .
3263434	0	IL-2	68,72	CD4	27,30	IL-2	CD4	116562(Tax:10116)	24932(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY express|dobj|receptors express|nsubj|thymocytes thymocytes|appos|- -|compound|END_ENTITY	Immature , double_negative -LRB- CD4 - , CD8 - -RRB- rat thymocytes do not express IL-2 receptors .
7522522	1	IL-2	79,83	CD4	115,118	IL-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY Analysis|nmod|production Analysis|nmod|+ +|compound|END_ENTITY	V. Analysis of IL-2 and IFN production by isolated CD4 + and CD8 + cells .
7586680	0	IL-2	38,42	CD4	56,59	IL-2	CD4	3558	920	Gene	Gene	Alterations|dep|START_ENTITY Alterations|nmod|cells cells|compound|END_ENTITY	Alterations in interleukin secretion -LRB- IL-2 and IL-4 -RRB- by CD4 and CD4 CD45RO cells from common variable immunodeficiency -LRB- CVI -RRB- patients .
7819141	0	IL-2	88,92	CD4	58,61	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	release|compound|START_ENTITY decreasing|dobj|release cAMP|advcl|decreasing cAMP|dobj|IL-4 IL-4|nmod|cells cells|compound|END_ENTITY	cAMP up-regulates IL-4 and IL-5 production from activated CD4 + T cells while decreasing IL-2 release and NF-AT induction .
7868930	0	IL-2	92,96	CD4	1,4	IL-2	CD4	3558	920	Gene	Gene	treated|nmod|START_ENTITY patients|acl|treated induce|nmod|patients induce|nsubj|TIL TIL|compound|END_ENTITY	-LSB- CD4 TIL -LRB- Tumor_Infiltrating_Lymphocytes -RRB- induce complete response in patients treated with IL-2 -LRB- Interleukin-2 -RRB- .
7901148	0	IL-2	103,107	CD4	35,38	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY activated|nmod|therapy activated|nsubj|Transfer Transfer|nmod|immunity immunity|nmod|+ +|compound|END_ENTITY	Transfer of tumor immunity by both CD4 + and CD8 + tumor infiltrating T lymphocytes activated in vivo by IL-2 therapy of tumor bearing mice .
7901231	0	IL-2	23,27	CD4	111,114	IL-2	CD4	3558	920	Gene	Gene	interleukin-2|appos|START_ENTITY production|compound|interleukin-2 due|nsubj|production due|nmod|abnormality abnormality|nmod|differentiation differentiation|compound|END_ENTITY	Reduced interleukin-2 -LRB- IL-2 -RRB- production in common variable immunodeficiency is due to a primary abnormality of CD4 + T cell differentiation .
7902374	0	IL-2	67,71	CD4	21,24	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY lymphocytes|nmod|secretion lymphocytes|compound|END_ENTITY	Subsets of activated CD4 T lymphocytes refractory for secretion of IL-2 are distinguished by expression of Ly-6A / E in BALB/c mice .
7930607	0	IL-2	49,53	CD4	25,28	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	depends|nmod|START_ENTITY depends|nsubj|production production|nmod|cells cells|compound|END_ENTITY	IL-9 production of naive CD4 + T cells depends on IL-2 , is synergistically enhanced by a combination of TGF-beta and IL-4 , and is inhibited by IFN-gamma .
8327861	0	IL-2	13,17	CD4	50,53	IL-2	CD4	3558	920	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|+ +|compound|END_ENTITY	Secretion of IL-2 , IL-3 , IL-4 , IL-6 and GM-CSF by CD4 + and CD8 + TCR alpha beta + T-cell clones derived early after allogeneic bone marrow transplantation .
8409385	0	IL-2	94,98	CD4	44,47	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|+ +|compound|END_ENTITY	Cytolytic activity of murine IL-2-producing CD4 + and CD8 + T cell clones cycles in response to IL-2 .
8589277	0	IL-2	78,82	CD4	21,24	IL-2	CD4	3558	920	Gene	Gene	activated|nmod|START_ENTITY lymphocytes|acl|activated Generation|dep|lymphocytes Generation|nmod|+ +|compound|END_ENTITY	Generation of memory CD4 + , CD8 + , CD45RO + and CD16 - lymphocytes activated with IL-2 , INF-gamma , and TNF-alpha with specific cytotoxicity against autologous_cervical_cancer cells in a mixed leukocyte-tumour cell culture .
8595373	0	IL-2	20,24	CD4	58,61	IL-2	CD4	3558	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Distinct pattern of IL-2 and IFN-gamma gene expression in CD4 and CD8 T cells : cytofluorometric analysis at a single cell level using non-radioactive probes .
8666775	0	IL-2	73,77	CD4	36,39	IL-2	CD4	3558	920	Gene	Gene	cells|nmod|START_ENTITY activation|dep|cells activation|nmod|45RO 45RO|compound|END_ENTITY	TCR-independent activation of human CD4 + 45RO - T cells by anti-CD28 plus IL-2 : Induction of clonal expansion and priming for a Th2 phenotype .
8675229	0	IL-2	84,88	CD4	99,102	IL-2	CD4	3558	920	Gene	Gene	dependent|amod|START_ENTITY T|amod|dependent T|compound|END_ENTITY	Growth regulatory effects of transforming_growth_factor-beta_1 and interleukin-2 on IL-2 dependent CD4 + T lymphoblastoid cell line .
8748254	0	IL-2	84,88	CD4	41,44	IL-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY act|nmod|production act|nsubj|cells cells|nummod|END_ENTITY	Mycobacterium bovis BCG-induced Th1 type CD4 + suppressor T cells act by suppressing IL-2 production and IL-2_receptor expression .
8786299	0	IL-2	10,14	CD4	63,66	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	enhance|nsubj|START_ENTITY enhance|dobj|priming priming|nmod|cells cells|compound|END_ENTITY	High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4 + T cells for IFN-gamma but have differential effects on priming for IL-4 .
9521080	0	IL-2	108,112	CD4	46,49	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY signal|nmod|secretion mediates|dobj|signal +|acl:relcl|mediates +|compound|END_ENTITY	A T cell activation antigen , Ly6C , induced on CD4 + Th1 cells mediates an inhibitory signal for secretion of IL-2 and proliferation in peripheral immune responses .
9590250	0	IL-2	104,108	CD4	0,3	IL-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	requirements|nmod|START_ENTITY +|dep|requirements +|compound|END_ENTITY	CD4 + and CD8 + T cell interactions in IFN-gamma and IL-4 responses to viral_infections : requirements for IL-2 .
9636688	0	IL-2	53,57	CD4	24,27	IL-2	CD4	3558	920	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|mAb mAb|compound|END_ENTITY	A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2 , IL-4 , and IL-10 secretion and expression of CD25 , CD40L , and CD69 .
9794390	0	IL-2	33,37	CD4	94,97	IL-2	CD4	3558	920	Gene	Gene	role|nmod|START_ENTITY Evidence|nmod|role Evidence|nmod|cells cells|compound|END_ENTITY	Evidence for a critical role for IL-2 in CD40-mediated activation of naive B cells by primary CD4 T cells .
7759875	0	IL-2	27,31	CD4-CD8	48,55	IL-2	CD4-CD8	3558	920;925	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Abnormal regulation of the IL-2 promoter in lpr CD4-CD8 - T lymphocytes results in constitutive expression of a novel nuclear factor of activated T cells-binding factor .
10415067	0	IL-2	107,111	CD44	32,36	IL-2	CD44	16183(Tax:10090)	12505(Tax:10090)	Gene	Gene	vascular_leak_syndrome|nmod|START_ENTITY Evidence|nmod|vascular_leak_syndrome Evidence|nmod|involvement involvement|nmod|END_ENTITY	Evidence for the involvement of CD44 in endothelial cell injury and induction of vascular_leak_syndrome by IL-2 .
11123292	0	IL-2	87,91	CD44	64,68	IL-2	CD44	3558	960	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Activated T lymphocytes regulate hyaluronan binding to monocyte CD44 via production of IL-2 and IFN-gamma .
12193230	0	IL-2	38,42	CD44	101,105	IL-2	CD44	16183(Tax:10090)	12505(Tax:10090)	Gene	Gene	cytokines|appos|START_ENTITY cytokines|appos|VCAM-1 VCAM-1|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
19635906	0	IL-2	96,100	CD44	0,4	IL-2	CD44	16183(Tax:10090)	12505(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY persistence|nmod|production promotes|dobj|persistence promotes|nsubj|costimulation costimulation|compound|END_ENTITY	CD44 costimulation promotes FoxP3 + regulatory T cell persistence and function via production of IL-2 , IL-10 , and TGF-beta .
8580076	0	IL-2	105,109	CD44	74,78	IL-2	CD44	16183(Tax:10090)	12505(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	CD44 plays a co-stimulatory role in murine T cell activation : ligation of CD44 selectively co-stimulates IL-2 production , but not proliferation in TCR-stimulated murine Th1 cells .
10224467	0	IL-2	56,60	CD8	20,23	IL-2	CD8	3558	925	Gene	Gene	chain|compound|START_ENTITY expression|nmod|chain expression|compound|END_ENTITY	IL-4 inhibits human CD8 T cell expression of the common IL-2 receptor gamma chain .
10820241	0	IL-2	61,65	CD8	124,127	IL-2	CD8	3558	925	Gene	Gene	delivers|xcomp|START_ENTITY expression|acl:relcl|delivers expression|parataxis|allows allows|dobj|proliferation proliferation|nmod|CD44high CD44high|compound|END_ENTITY	Constitutive expression of a chimeric receptor that delivers IL-2 / IL-15 signals allows antigen-independent proliferation of CD8 + CD44high but not other T cells .
10882412	0	IL-2	56,60	CD8	27,30	IL-2	CD8	3558	925	Gene	Gene	chain|compound|START_ENTITY induced|nmod|chain IFN|parataxis|induced IFN|nsubj|Loss Loss|nmod|expression expression|nmod|END_ENTITY	Loss of CD28 expression on CD8 -LRB- + -RRB- T cells is induced by IL-2 receptor gamma chain signalling cytokines and type I IFN , and increases susceptibility to activation-induced apoptosis .
10975812	0	IL-2	17,21	CD8	59,62	IL-2	CD8	3558	925	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|memory memory|compound|END_ENTITY	The dual role of IL-2 in the generation and maintenance of CD8 + memory T cells .
11477452	0	IL-2	114,118	CD8	138,141	IL-2	CD8	3558	925	Gene	Gene	cDNA|compound|START_ENTITY harboring|dobj|cDNA vector|acl|harboring injection|nmod|vector mice|nmod|injection tumors|nmod|mice Immunotherapy|nmod|tumors Immunotherapy|dep|induction induction|nmod|immunity immunity|compound|END_ENTITY	Immunotherapy of established tumors in mice by intratumoral injection of an adenovirus vector harboring the human IL-2 cDNA : induction of CD8 -LRB- + -RRB- T-cell immunity and NK activity .
11591778	0	IL-2	0,4	CD8	137,140	IL-2	CD8	3558	925	Gene	Gene	promotes|dep|START_ENTITY promotes|dobj|END_ENTITY	IL-2 during in vitro priming promotes subsequent engraftment and successful adoptive tumor immunotherapy by persistent memory phenotypic CD8 -LRB- + -RRB- T cells .
12023352	0	IL-2	19,23	CD8	69,72	IL-2	CD8	3558	925	Gene	Gene	role|nmod|START_ENTITY extralymphoid|nsubj|role extralymphoid|dobj|responses responses|compound|END_ENTITY	Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses .
12165496	0	IL-2	20,24	CD8	59,62	IL-2	CD8	3558	925	Gene	Gene	effects|nmod|START_ENTITY effects|dep|growth growth|compound|END_ENTITY	Opposing effects of IL-2 in tumor immunotherapy : promoting CD8 T cell growth and inducing apoptosis .
12963692	0	IL-2	99,103	CD8	40,43	IL-2	CD8	3558	925	Gene	Gene	production|compound|START_ENTITY reconstitutes|dobj|production effector|acl:relcl|reconstitutes effector|compound|END_ENTITY	Restoration of CD28 expression in CD28 - CD8 + memory effector T cells reconstitutes antigen-induced IL-2 production .
14634080	0	IL-2	0,4	CD8	43,46	IL-2	CD8	3558	925	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|initiation initiation|nmod|cycling cycling|compound|END_ENTITY	IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion .
15024180	0	IL-2	10,14	CD8	26,29	IL-2	CD8	3558	925	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|+ +|compound|END_ENTITY	Effect of IL-2 therapy on CD8 + cell noncytotoxic anti-HIV response during primary HIV-1_infection .
15223897	0	IL-2	47,51	CD8	35,38	IL-2	CD8	3558	925	Gene	Gene	production|compound|START_ENTITY +|dobj|production +|nsubj|inhibition inhibition|nmod|END_ENTITY	Defective inhibition of peripheral CD8 + T cell IL-2 production by anti-calcineurin drugs during acute liver allograft rejection .
1531763	0	IL-2	82,86	CD8	44,47	IL-2	CD8	3558	925	Gene	Gene	pathway|compound|START_ENTITY precursors|nmod|pathway END_ENTITY|dep|precursors	IL-7 induces proliferation of CD3 - / low CD4 - CD8 - human thymocyte precursors by an IL-2 independent pathway .
15384078	0	IL-2	55,59	CD8	80,83	IL-2	CD8	3558	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Frontline : An in-depth evaluation of the production of IL-2 by antigen-specific CD8 T cells in vivo .
16456009	0	IL-2	100,104	CD8	54,57	IL-2	CD8	3558	925	Gene	Gene	inhibition|compound|START_ENTITY enhances|nmod|inhibition enhances|dobj|responses responses|compound|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16751372	0	IL-2	0,4	CD8	46,49	IL-2	CD8	3558	925	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|cells cells|compound|END_ENTITY	IL-2 is required for the activation of memory CD8 + T cells via antigen cross-presentation .
16751420	0	IL-2	14,18	CD8	50,53	IL-2	CD8	3558	925	Gene	Gene	Modulation|nmod|START_ENTITY expression|amod|Modulation expression|nmod|cells cells|compound|END_ENTITY	Modulation by IL-2 of CD70 and CD27 expression on CD8 + T cells : importance for the therapeutic effectiveness of cell transfer immunotherapy .
1676547	0	IL-2	76,80	CD8	25,28	IL-2	CD8	3558	925	Gene	Gene	transcription|compound|START_ENTITY evidence|nmod|transcription Activation|dep|evidence Activation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activation of peripheral CD8 + T lymphocytes via CD28 plus CD2 : evidence for IL-2 gene transcription mediated by CD28 activation .
16806475	0	IL-2	13,17	CD8	39,42	IL-2	CD8	3558	925	Gene	Gene	deprivation|compound|START_ENTITY deprivation|nmod|blasts blasts|compound|END_ENTITY	Apoptosis by IL-2 deprivation in human CD8 + T cell blasts predominates over death receptor ligation , requires Bim expression and is associated with Mcl-1 loss .
16859558	0	IL-2	0,4	CD8	78,81	IL-2	CD8	3558	925	Gene	Gene	production|compound|START_ENTITY correlates|nsubj|production correlates|nmod|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	IL-2 production correlates with effector cell differentiation in HIV-specific CD8 + T cells .
17414320	0	IL-2	0,4	CD8	98,101	IL-2	CD8	3558	925	Gene	Gene	START_ENTITY|dep|induction induction|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells .
17664293	0	IL-2	73,77	CD8	6,9	IL-2	CD8	3558	925	Gene	Gene	treatment|compound|START_ENTITY differentiate|nmod|treatment +|ccomp|differentiate +|nsubj|END_ENTITY	Naive CD8 + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo .
17664293	0	IL-2	83,87	CD8	6,9	IL-2	CD8	3558	925	Gene	Gene	treatment|compound|START_ENTITY differentiate|nmod|treatment +|ccomp|differentiate +|nsubj|END_ENTITY	Naive CD8 + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo .
17664294	0	IL-2	75,79	CD8	54,57	IL-2	CD8	3558	925	Gene	Gene	driven|nmod|START_ENTITY driven|nsubj|form form|nmod|proliferation proliferation|nmod|cells cells|amod|naive naive|dep|END_ENTITY	An intense form of homeostatic proliferation of naive CD8 + cells driven by IL-2 .
18178855	0	IL-2	97,101	CD8	18,21	IL-2	CD8	3558	925	Gene	Gene	differentiation|nmod|START_ENTITY differentiation|nsubj|Control Control|nmod|cell cell|nummod|END_ENTITY	Control of memory CD8 + T cell differentiation by CD80/CD86-CD 28 costimulation and restoration by IL-2 during the recall response .
18273057	0	IL-2	8,12	CD8	78,81	IL-2	CD8	3558	925	Gene	Gene	Role|nmod|START_ENTITY secreted|nsubj|Role secreted|advcl|enhancing enhancing|dobj|responses responses|compound|END_ENTITY	Role of IL-2 secreted by PADRE-specific CD4 + T cells in enhancing E7-specific CD8 + T-cell immune responses .
18276844	0	IL-2	0,4	CD8	59,62	IL-2	CD8	3558	925	Gene	Gene	confer|nsubj|START_ENTITY confer|xcomp|opposing opposing|nmod|cells cells|nummod|END_ENTITY	IL-2 and IL-21 confer opposing differentiation programs to CD8 + T cells for adoptive immunotherapy .
19011158	0	IL-2	0,4	CD8	66,69	IL-2	CD8	3558	925	Gene	Gene	cytokines|compound|START_ENTITY regulate|nsubj|cytokines regulate|dobj|+ +|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
19801515	0	IL-2	86,90	CD8	37,40	IL-2	CD8	3558	925	Gene	Gene	antibody|amod|START_ENTITY complexes|nmod|antibody driven|nmod|complexes cells|acl|driven +|dobj|cells +|nsubj|END_ENTITY	In vivo expansion of activated naive CD8 + T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy .
19841187	0	IL-2	115,119	CD8	18,21	IL-2	CD8	3558	925	Gene	Gene	production|compound|START_ENTITY characterized|nmod|production signature|acl|characterized have|dobj|signature have|nsubj|cells cells|nummod|END_ENTITY	Human late memory CD8 + T cells have a distinct cytokine signature characterized by CC chemokine production without IL-2 production .
19901991	0	IL-2	20,24	CD8	71,74	IL-2	CD8	3558	925	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|advances advances|dep|responses responses|compound|END_ENTITY	CD4 + T cell-derived IL-2 signals during early priming advances primary CD8 + T cell responses .
20483725	0	IL-2	19,23	CD8	73,76	IL-2	CD8	3558	925	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|differentiation differentiation|nmod|effector effector|nummod|END_ENTITY	Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8 + effector and memory T cells .
21430221	0	IL-2	24,28	CD8	93,96	IL-2	CD8	3558	925	Gene	Gene	signaling|compound|START_ENTITY sensitivity|nmod|signaling regulates|nsubj|sensitivity regulates|dobj|responsiveness responsiveness|nmod|cells cells|nummod|END_ENTITY	Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8 -LRB- + -RRB- T cells in a melanoma model .
21482735	0	IL-2	24,28	CD8	78,81	IL-2	CD8	3558	925	Gene	Gene	outcome|nmod|START_ENTITY outcome|parataxis|+ +|nsubj|therapy therapy|nmod|END_ENTITY	Differential outcome of IL-2 / anti-IL-2 complex therapy on effector and memory CD8 + T cells following vaccination with an adenoviral vector encoding EBV epitopes .
21502514	0	IL-2	88,92	CD8	37,40	IL-2	CD8	3558	925	Gene	Gene	homeostasis|compound|START_ENTITY differentiation|nmod|homeostasis differentiation|compound|END_ENTITY	CD4 + CD25 + regulatory T cells control CD8 + T-cell effector differentiation by modulating IL-2 homeostasis .
21718737	0	IL-2	69,73	CD8	75,78	IL-2	CD8	3558	925	Gene	Gene	background|compound|START_ENTITY background|compound|END_ENTITY	Immunogenicity assay validation for an HIV vaccine trial : high IFNy + / IL-2 + CD8 + T cells background in healthy Thais .
21804558	0	IL-2	10,14	CD8	65,68	IL-2	CD8	3558	925	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|expansion expansion|nmod|cells cells|amod|END_ENTITY	Autocrine IL-2 is required for secondary population expansion of CD8 -LRB- + -RRB- memory T cells .
21849683	0	IL-2	74,78	CD8	39,42	IL-2	CD8	3558	925	Gene	Gene	restriction|compound|START_ENTITY size|nmod|restriction size|compound|END_ENTITY	Regulatory_T cells selectively control CD8 + T cell effector pool size via IL-2 restriction .
24166977	0	IL-2	51,55	CD8	25,28	IL-2	CD8	3558	925	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|features features|nmod|cell cell|compound|END_ENTITY	Unique features of naive CD8 + T cell activation by IL-2 .
24367005	0	IL-2	103,107	CD8	62,65	IL-2	CD8	3558	925	Gene	Gene	maintaining|dobj|START_ENTITY prolong|advcl|maintaining prolong|dobj|division division|nmod|cells cells|compound|END_ENTITY	IL-12 and type I interferon prolong the division of activated CD8 T cells by maintaining high-affinity IL-2 signaling in vivo .
25015830	0	IL-2	0,4	CD8	54,57	IL-2	CD8	3558	925	Gene	Gene	induction|compound|START_ENTITY key|nsubj|induction key|nmod|signal signal|nmod|differentiation differentiation|compound|END_ENTITY	IL-2 induction of Blimp-1 is a key in vivo signal for CD8 + short-lived effector T cell differentiation .
25548225	0	IL-2	124,128	CD8	112,115	IL-2	CD8	3558	925	Gene	Gene	Promoter|compound|START_ENTITY Promoter|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
25548225	0	IL-2	124,128	CD8	40,43	IL-2	CD8	3558	925	Gene	Gene	Promoter|compound|START_ENTITY Foxp3|nmod|Promoter Methylation|nmod|Foxp3 Methylation|nmod|Binding Binding|compound|END_ENTITY	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
2572284	0	IL-2	216,220	CD8	170,173	IL-2	CD8	3558	925	Gene	Gene	presence|nmod|START_ENTITY cells|nmod|presence cells|nummod|END_ENTITY	T-cell ontogeny after autologous bone marrow transplantation : failure to synthesize interleukin-2 -LRB- IL-2 -RRB- and lack of CD2 - and CD3-mediated proliferation by both CD4 - and CD8 + cells even in the presence of exogeneous IL-2 .
25946103	0	IL-2	118,122	CD8	0,3	IL-2	CD8	3558	925	Gene	Gene	Fate|nmod|START_ENTITY +|dobj|Fate +|nsubj|END_ENTITY	CD8 + T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2 .
25946103	0	IL-2	118,122	CD8	0,3	IL-2	CD8	3558	925	Gene	Gene	Fate|nmod|START_ENTITY +|dobj|Fate +|nsubj|END_ENTITY	CD8 + T Cell Fate and Function Influenced by Antigen-Specific Virus-Like Nanoparticles Co-Expressing Membrane Tethered IL-2 .
25962156	0	IL-2	108,112	CD8	71,74	IL-2	CD8	3558	925	Gene	Gene	Signaling|compound|START_ENTITY Cells|nmod|Signaling Cells|nsubj|Primary Primary|nmod|T T|compound|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
25962156	0	IL-2	113,117	CD8	71,74	IL-2	CD8	3558	925	Gene	Gene	Signaling|compound|START_ENTITY Cells|nmod|Signaling Cells|nsubj|Primary Primary|nmod|T T|compound|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
26947179	0	IL-2	0,4	CD8	37,40	IL-2	CD8	3558	925	Gene	Gene	consumption|compound|START_ENTITY consumption|nmod|cells cells|compound|END_ENTITY	IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic_lymphohistiocytosis .
7622198	0	IL-2	90,94	CD8	59,62	IL-2	CD8	3558	925	Gene	Gene	clone|nmod|START_ENTITY clone|nsubj|Modulation Modulation|nmod|functions functions|nmod|cell cell|amod|cytotoxic cytotoxic|nmod:npmod|+ +|nummod|END_ENTITY	Modulation of the functions of dengue virus-specific human CD8 + cytotoxic T cell clone by IL-2 , IL-7 and IFN_gamma .
7908892	0	IL-2	95,99	CD8	0,3	IL-2	CD8	3558	925	Gene	Gene	produce|dobj|START_ENTITY capacity|acl|produce differ|nmod|capacity differ|nsubj|subsets subsets|nummod|END_ENTITY	CD8 + T-cell subsets defined by expression of CD45 isoforms differ in their capacity to produce IL-2 , IFN-gamma and TNF-beta .
7989743	0	IL-2	0,4	CD8	27,30	IL-2	CD8	3558	925	Gene	Gene	support|nsubj|START_ENTITY support|dobj|growth growth|nmod|cells cells|compound|END_ENTITY	IL-2 can support growth of CD8 + T cells but not CD4 + T cells of human IL-2_receptor_beta-chain transgenic_mice .
9190908	0	IL-2	0,4	CD8	57,60	IL-2	CD8	3558	925	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|+ +|compound|END_ENTITY	IL-2 induces Fas_ligand / Fas -LRB- CD95L/CD95 -RRB- cytotoxicity in CD8 + and CD4 + T lymphocyte clones .
9634197	0	IL-2	118,122	CD8	111,114	IL-2	CD8	3558	925	Gene	Gene	antibody|amod|START_ENTITY END_ENTITY|nmod|antibody	The regulation of phenotype and function of human liver CD3 + / CD56 + lymphocytes , and cells that also co-express CD8 by IL-2 , IL-12 and anti-CD3 monoclonal antibody .
9880014	0	IL-2	92,96	CD8	62,65	IL-2	CD8	3558	925	Gene	Gene	gonadotrophin|amod|START_ENTITY leukocytes|nmod|gonadotrophin leukocytes|nsubj|+ +|compound|END_ENTITY	In vitro reactivation of latent equid_herpesvirus-1 from CD5 + / CD8 + leukocytes indirectly by IL-2 or chorionic gonadotrophin .
17392576	0	IL-2	164,168	CXCL8	188,193	IL-2	CXCL8	3558	3576	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
25785643	0	IL-2	14,18	Cdk5	0,4	IL-2	Cdk5	16183(Tax:10090)	12568(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Cdk5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex .
20729304	0	IL-2	26,30	Clusterin	0,9	IL-2	Clusterin	16183(Tax:10090)	12759(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Clusterin synergizes with IL-2 for the expansion and IFN-y production of natural killer cells .
9925799	0	IL-2	71,75	EL-4	100,104	IL-2	EL-4	16183(Tax:10090)	111979(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Propanil affects transcriptional and posttranscriptional regulation of IL-2 expression in activated EL-4 cells .
7876544	0	IL-2	16,20	ETS1	8,12	IL-2	ETS1	3558	2113	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of ETS1 in IL-2 gene expression .
16645171	0	IL-2	0,4	FOXP3	15,20	IL-2	FOXP3	3558	50943	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	IL-2 regulates FOXP3 expression in human CD4 + CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo .
17414320	0	IL-2	0,4	FOXP3	49,54	IL-2	FOXP3	3558	50943	Gene	Gene	START_ENTITY|dep|induction induction|nmod|expression expression|nummod|END_ENTITY	IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells .
19234188	0	IL-2	58,62	FOXP3	72,77	IL-2	FOXP3	3558	50943	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Analysis of adhesion molecules , target cells , and role of IL-2 in human FOXP3 + regulatory T cell suppressor function .
20137305	0	IL-2	35,39	FOXP3	90,95	IL-2	FOXP3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	-LSB- Combination of dexamethasone with IL-2 selectively induces the expansion of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- regulatory T cells in vivo and suppresses graft versus host disease . -RSB- .
21179414	0	IL-2	85,89	FOXP3	45,50	IL-2	FOXP3	3558	50943	Gene	Gene	generated|nmod|START_ENTITY END_ENTITY|ccomp|generated	Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2 , TGF-b and retinoic_acid .
22276195	0	IL-2	114,118	FOXP3	44,49	IL-2	FOXP3	3558	50943	Gene	Gene	administration|compound|START_ENTITY +|nmod|administration +|nsubj|END_ENTITY	In vivo expansion of na ve CD4 + CD25 -LRB- high -RRB- FOXP3 + regulatory T cells in patients with colorectal_carcinoma after IL-2 administration .
22969764	0	IL-2	0,4	FOXP3	102,107	IL-2	FOXP3	3558	50943	Gene	Gene	Expression|compound|START_ENTITY Cells|nsubj|Expression Cells|dobj|Depends Depends|nmod|Levels Levels|nmod|END_ENTITY	IL-2 Expression in Activated Human Memory FOXP3 -LRB- + -RRB- Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of T Cell Activation .
22969764	0	IL-2	0,4	FOXP3	42,47	IL-2	FOXP3	3558	50943	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	IL-2 Expression in Activated Human Memory FOXP3 -LRB- + -RRB- Cells Critically Depends on the Cellular Levels of FOXP3 as Well as of Four Transcription Factors of T Cell Activation .
10556800	0	IL-2	28,32	FasL	0,4	IL-2	FasL	3558	356	Gene	Gene	activation|nmod|START_ENTITY promoter|acl|activation promoter|amod|END_ENTITY	FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3 .
10229820	0	IL-2	44,48	Fibroblast_growth_factor-1	0,26	IL-2	Fibroblast growth factor-1	3558	2246	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- enhances IL-2 production and nuclear translocation of NF-kappaB in FGF_receptor-bearing Jurkat T cells .
19635906	0	IL-2	96,100	FoxP3	28,33	IL-2	FoxP3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY persistence|nmod|production persistence|compound|END_ENTITY	CD44 costimulation promotes FoxP3 + regulatory T cell persistence and function via production of IL-2 , IL-10 , and TGF-beta .
21469091	0	IL-2	8,12	FoxP3	76,81	IL-2	FoxP3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY leads|nsubj|expression leads|nmod|increase increase|nmod|cells cells|compound|END_ENTITY	Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3 + CD4 + T cells with limited suppressor activity .
24633065	0	IL-2	82,86	FoxP3	0,5	IL-2	FoxP3	3558	50943	Gene	Gene	availability|compound|START_ENTITY promote|nmod|availability promote|nsubj|cells cells|amod|END_ENTITY	FoxP3 + regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability .
27049955	0	IL-2	47,51	FoxP3	87,92	IL-2	FoxP3	3558	50943	Gene	Gene	Signaling|nmod|START_ENTITY Production|nsubj|Signaling Production|dep|Suppression Suppression|compound|END_ENTITY	4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4 + CD25 + FoxP3 + T Regulatory Cell Suppression .
15753206	0	IL-2	139,143	Foxp3	35,40	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	neutralization|compound|START_ENTITY regulatory|nmod|neutralization regulatory|nsubj|maintenance maintenance|nmod|CD4 CD4|amod|END_ENTITY	Homeostatic maintenance of natural Foxp3 -LRB- + -RRB- CD25 -LRB- + -RRB- CD4 -LRB- + -RRB- regulatory T cells by interleukin _ -LRB- IL -RRB- -2 and induction of autoimmune_disease by IL-2 neutralization .
16304057	0	IL-2	0,4	Foxp3	44,49	IL-2	Foxp3	3558	50943	Gene	Gene	administration|compound|START_ENTITY increases|nsubj|administration increases|dobj|END_ENTITY	IL-2 administration increases CD4 + CD25 -LRB- hi -RRB- Foxp3 + regulatory T cells in cancer patients .
17015695	0	IL-2	26,30	Foxp3	93,98	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	availability|nmod|START_ENTITY determinant|nsubj|availability determinant|acl|controlling controlling|dobj|production production|nmod|T T|compound|END_ENTITY	Selective availability of IL-2 is a major determinant controlling the production of CD4 + CD25 + Foxp3 + T regulatory cells .
17130555	0	IL-2	60,64	Foxp3	16,21	IL-2	Foxp3	3558	20371(Tax:10090)	Gene	Gene	implications|amod|START_ENTITY implications|nsubj|Upregulation Upregulation|nmod|expression expression|amod|END_ENTITY	Upregulation of Foxp3 expression in mouse and human Treg is IL-2 / STAT5 dependent : implications for the NOD STAT5B mutation in diabetes pathogenesis .
17182565	0	IL-2	0,4	Foxp3	81,86	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nsubjpass|activation required|nmod|development development|nmod|cells cells|amod|END_ENTITY	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells .
17277105	0	IL-2	0,4	Foxp3	72,77	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|xcomp|convert convert|dobj|CD25 CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17371955	0	IL-2	14,18	Foxp3	67,72	IL-2	Foxp3	3558	50943	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	Cutting Edge : IL-2 is essential for TGF-beta-mediated induction of Foxp3 + T regulatory cells .
18395858	0	IL-2	17,21	Foxp3	80,85	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|Treg Treg|compound|END_ENTITY	Critical role of IL-2 and TGF-beta in generation , function and stabilization of Foxp3 + CD4 + Treg .
18490709	0	IL-2	60,64	Foxp3	14,19	IL-2	Foxp3	3558	50943	Gene	Gene	induced|nmod|START_ENTITY cells|acl|induced resistant|nsubj|cells +|ccomp|resistant +|nsubj|CD25 CD25|compound|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18493984	0	IL-2	0,4	Foxp3	49,54	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	induces|dep|START_ENTITY induces|dobj|END_ENTITY	IL-2 induces in vivo suppression by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
18941219	0	IL-2	21,25	Foxp3	51,56	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	variants|compound|START_ENTITY variants|nmod|cell cell|compound|END_ENTITY	Impact of protective IL-2 allelic variants on CD4 + Foxp3 + regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice .
20081380	0	IL-2	24,28	Foxp3	70,75	IL-2	Foxp3	3558	50943	Gene	Gene	START_ENTITY|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	Differential effects of IL-2 and IL-21 on expansion of the CD4 + CD25 + Foxp3 + T regulatory cells with redundant roles in natural killer cell mediated antibody dependent cellular cytotoxicity in chronic_lymphocytic_leukemia .
21059266	0	IL-2	0,4	Foxp3	52,57	IL-2	Foxp3	3558	50943	Gene	Gene	START_ENTITY|nmod|target target|nmod|restoration restoration|nmod|function function|compound|END_ENTITY	IL-2 as a therapeutic target for the restoration of Foxp3 + regulatory T cell function in organ-specific autoimmunity : implications in pathophysiology and translation to human disease .
21244339	0	IL-2	0,4	Foxp3	44,49	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|nsubj|production promotes|xcomp|expansion expansion|nsubj|END_ENTITY	IL-2 production by dendritic cells promotes Foxp3 -LRB- + -RRB- regulatory T-cell expansion in autoimmune-resistant NOD congenic mice .
21389253	0	IL-2	0,4	Foxp3	54,59	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|advcl|maintaining maintaining|dobj|balance balance|nmod|cells cells|compound|END_ENTITY	IL-2 contributes to maintaining a balance between CD4 + Foxp3 + regulatory T cells and effector CD4 + T cells required for immune control of blood-stage malaria_infection .
21525380	0	IL-2	0,4	Foxp3	31,36	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|stability stability|nmod|expression expression|amod|END_ENTITY	IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3 + T cells in vivo .
21525380	0	IL-2	0,4	Foxp3	68,73	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|cells cells|amod|END_ENTITY	IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3 + T cells in vivo .
23126599	0	IL-2	83,87	Foxp3	47,52	IL-2	Foxp3	3558	50943	Gene	Gene	START_ENTITY|nsubj|induction induction|nmod|CD4 CD4|compound|END_ENTITY	The ex vivo induction of human CD103 CD25hi Foxp3 CD4 and CD8 Tregs is IL-2 and TGF-b1 dependent .
23884888	0	IL-2	16,20	Foxp3	45,50	IL-2	Foxp3	16183(Tax:10090)	20371(Tax:10090)	Gene	Gene	increases|compound|START_ENTITY islet|nsubj|increases islet|dobj|Treg Treg|compound|END_ENTITY	b-cell-specific IL-2 therapy increases islet Foxp3 + Treg and suppresses type 1 diabetes in NOD mice .
25548225	0	IL-2	124,128	Foxp3	99,104	IL-2	Foxp3	3558	50943	Gene	Gene	Promoter|compound|START_ENTITY END_ENTITY|nmod|Promoter	Modulating DNA Methylation in Activated CD8 + T Cells Inhibits Regulatory T Cell-Induced Binding of Foxp3 to the CD8 + T Cell IL-2 Promoter .
26886923	0	IL-2	99,103	Foxp3	54,59	IL-2	Foxp3	3558	50943	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|nmod|Cells Cells|compound|END_ENTITY	Comparative Analysis of Protocols to Induce Human CD4 + Foxp3 + Regulatory T Cells by Combinations of IL-2 , TGF-beta , Retinoic_Acid , Rapamycin and Butyrate .
7506580	0	IL-2	208,212	G-CSF	187,192	IL-2	G-CSF	3558	1440	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
1634251	0	IL-2	109,113	GM-CSF	169,175	IL-2	GM-CSF	3558	1437	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	Natural killer -LRB- NK -RRB- cell activity in human long-term bone marrow cultures -LRB- LTBMC -RRB- : effects of interleukin-2 -LRB- IL-2 -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on the progenitor cells .
16783532	0	IL-2	107,111	GM-CSF	80,86	IL-2	GM-CSF	3558	1437	Gene	Gene	granulocyte-macrophage_colony_stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony_stimulating_factor|appos|END_ENTITY	In vivo effects of sequential granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- and interleukin-2 -LRB- IL-2 -RRB- on circulating dendritic cells -LRB- DC -RRB- in patients with surgically resected high risk cutaneous melanoma .
7506580	0	IL-2	208,212	GM-CSF	194,200	IL-2	GM-CSF	3558	1437	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
25304727	0	IL-2	33,37	IFN-a	58,63	IL-2	IFN-a	3558	3440	Gene	Gene	Interleukin-2|appos|START_ENTITY Interleukin-2|appos|END_ENTITY	Adjuvant Low-Dose Interleukin-2 -LRB- IL-2 -RRB- Plus Interferon-a -LRB- IFN-a -RRB- in Operable Renal_Cell_Carcinoma -LRB- RCC -RRB- : A Phase III , Randomized , Multicentre Trial of the Italian Oncology Group for Clinical Research -LRB- GOIRC -RRB- .
10679063	0	IL-2	21,25	IFN-alpha	0,9	IL-2	IFN-alpha	3558	3439	Gene	Gene	production|compound|START_ENTITY reduces|dobj|production reduces|nsubj|2b 2b|amod|END_ENTITY	IFN-alpha 2b reduces IL-2 production and IL-2_receptor function in primary CD4 + T cells .
15622622	0	IL-2	70,74	IFN-alpha	12,21	IL-2	IFN-alpha	3558	3439	Gene	Gene	lymphocytes|compound|START_ENTITY END_ENTITY|nmod|lymphocytes	-LSB- Effects of IFN-alpha on the expressions of perforin and granzymes in IL-2 activated lymphocytes -RSB- .
1987429	0	IL-2	41,45	IFN-alpha	21,30	IL-2	IFN-alpha	16183(Tax:10090)	111654(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY augmented|dobj|therapy augmented|nsubj|survival survival|nmod|END_ENTITY	Enhanced survival of IFN-alpha augmented IL-2 therapy of pulmonary metastases : efficacy comparable to interleukin-2 and lymphokine activated killer cells .
7919965	0	IL-2	121,125	IFN-alpha	91,100	IL-2	IFN-alpha	3558	3439	Gene	Gene	interferon-alpha|appos|START_ENTITY interferon-alpha|appos|END_ENTITY	HLA class I alleles and responsiveness of melanoma to immunotherapy with interferon-alpha -LRB- IFN-alpha -RRB- and interleukin-2 -LRB- IL-2 -RRB- .
8569177	0	IL-2	106,110	IFN-alpha	131,140	IL-2	IFN-alpha	16183(Tax:10090)	111654(Tax:10090)	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8899186	0	IL-2	87,91	IFN-alpha	92,101	IL-2	IFN-alpha	3558	3439	Gene	Gene	receiving|nmod|START_ENTITY patients|acl|receiving receptors|nmod|patients Soluble|dobj|receptors lymphocytes|dep|Soluble lymphocytes|amod|END_ENTITY	Soluble IL-6 receptors -LRB- sIL-6R -RRB- in hematological patients receiving immunotherapy with IL-2 / IFN-alpha or donor lymphocytes following bone marrow transplantation .
10714558	0	IL-2	35,39	IFN-gamma	112,121	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY Interleukin-18|nmod|combination enhances|nsubj|Interleukin-18 enhances|advcl|inducing inducing|dobj|amounts amounts|nmod|END_ENTITY	Interleukin-18 in combination with IL-2 enhances natural killer cell activity without inducing large amounts of IFN-gamma in vivo .
11712854	0	IL-2	144,148	IFN-gamma	133,142	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|appos|production	HLA-DQ6 transgenic_mice resistance to experimental autoimmune_myasthenia_gravis is linked to reduced acetylcholine receptor-specific IFN-gamma , IL-2 and IL-10 production .
11745353	0	IL-2	83,87	IFN-gamma	32,41	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	administration|nmod|START_ENTITY secrete|advcl|administration secrete|dobj|levels levels|nmod|END_ENTITY	NK cells secrete high levels of IFN-gamma in response to in vivo administration of IL-2 .
12444145	0	IL-2	41,45	IFN-gamma	31,40	IL-2	IFN-gamma	3558	3458	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Presence of HIV-1 Gag-specific IFN-gamma + IL-2 + and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1_infection .
1531996	0	IL-2	69,73	IFN-gamma	57,66	IL-2	IFN-gamma	3558	3458	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Preferential messenger RNA expression of Th1-type cells -LRB- IFN-gamma + , IL-2 + -RRB- in classical delayed-type -LRB- tuberculin -RRB- hypersensitivity reactions in human skin .
15760388	0	IL-2	47,51	IFN-gamma	0,9	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY limiting|dobj|production CTL|advcl|limiting CTL|nsubj|decreases decreases|amod|END_ENTITY	IFN-gamma decreases CTL generation by limiting IL-2 production : A feedback loop controlling effector cell production .
15806975	0	IL-2	135,139	IFN-gamma	68,77	IL-2	IFN-gamma	3558	3458	Gene	Gene	levels|appos|START_ENTITY interleukin-2|dobj|levels interleukin-2|nsubj|efficacy efficacy|appos|interferon-gamma interferon-gamma|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
15951352	0	IL-2	0,4	IFN-gamma	41,50	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophages .
16256965	0	IL-2	0,4	IFN-gamma	24,33	IL-2	IFN-gamma	3558	3458	Gene	Gene	absorption|compound|START_ENTITY affects|nsubj|absorption affects|dobj|END_ENTITY	IL-2 absorption affects IFN-gamma and IL-5 , but not IL-4 producing memory T cells in double color cytokine ELISPOT assays .
18776133	0	IL-2	19,23	IFN-gamma	0,9	IL-2	IFN-gamma	3558	3458	Gene	Gene	resistance|amod|START_ENTITY reverses|dobj|resistance reverses|nsubj|END_ENTITY	IFN-gamma reverses IL-2 - and IL-4-mediated T-cell steroid resistance .
1906383	0	IL-2	70,74	IFN-gamma	94,103	IL-2	IFN-gamma	3558	3458	Gene	Gene	interferon-gamma|compound|START_ENTITY interferon-gamma|appos|END_ENTITY	Effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- , tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes .
1907306	0	IL-2	32,36	IFN-gamma	37,46	IL-2	IFN-gamma	3558	3458	Gene	Gene	expression|nmod|START_ENTITY expression|dep|mRNA mRNA|amod|END_ENTITY	Restricted T cell expression of IL-2 / IFN-gamma mRNA in human inflammatory_disease .
2110548	0	IL-2	29,33	IFN-gamma	6,15	IL-2	IFN-gamma	3558	3458	Gene	Gene	receptors|compound|START_ENTITY up-regulates|dobj|receptors up-regulates|nsubj|END_ENTITY	Human IFN-gamma up-regulates IL-2 receptors in mitogen-activated T lymphocytes .
7774054	0	IL-2	18,22	IFN-gamma	51,60	IL-2	IFN-gamma	3558	3458	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of IL-2 , IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- mRNA using liver biopsies at different phases of acute exacerbation of chronic_hepatitis_B .
8015314	0	IL-2	85,89	IFN-gamma	90,99	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|dep|release release|amod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8097754	0	IL-2	71,75	IFN-gamma	0,9	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|dep|END_ENTITY	IFN-gamma , but not IL-4 , synthesis by antigen-primed murine T cells is IL-2 dependent .
8622992	0	IL-2	25,29	IFN-gamma	42,51	IL-2	IFN-gamma	3558	3458	Gene	Gene	interleukin|appos|START_ENTITY interleukin|dep|END_ENTITY	Comparative interleukin -LRB- IL-2 -RRB- / interferon IFN-gamma and IL-4 / IL-10 responses during acute infection of macaques inoculated with attenuated nef-truncated or pathogenic SICmac251 virus .
8786299	0	IL-2	10,14	IFN-gamma	80,89	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	enhance|nsubj|START_ENTITY enhance|nmod|END_ENTITY	High-dose IL-2 and IL-15 enhance the in vitro priming of naive CD4 + T cells for IFN-gamma but have differential effects on priming for IL-4 .
8948120	0	IL-2	138,142	IFN-gamma	77,86	IL-2	IFN-gamma	3558	3458	Gene	Gene	stimulation|compound|START_ENTITY cells|nmod|stimulation histamine|nmod|cells metabolites|nmod|histamine metabolites|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation .
9590250	0	IL-2	104,108	IFN-gamma	37,46	IL-2	IFN-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	requirements|nmod|START_ENTITY +|dep|requirements +|nmod|END_ENTITY	CD4 + and CD8 + T cell interactions in IFN-gamma and IL-4 responses to viral_infections : requirements for IL-2 .
9933441	0	IL-2	5,9	IFN-gamma	29,38	IL-2	IFN-gamma	3558	3458	Gene	Gene	interferon-gamma|compound|START_ENTITY Th1|dep|interferon-gamma Th1|appos|END_ENTITY	Th1 -LRB- IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- -RRB- and Th2 -LRB- IL-10 , IL-4 -RRB- cytokine production by peripheral blood mononuclear cells -LRB- PBMC -RRB- from patients with systemic_lupus_erythematosus -LRB- SLE -RRB- .
11057100	0	IL-2	29,33	IFN_gamma	51,60	IL-2	IFN gamma	3558	3458	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	-LSB- Secretion of interleukin-2 -LRB- IL-2 -RRB- and interferon -LRB- IFN_gamma -RRB- in whole blood cell culture stimulated with mitogens in patients with lung_neoplasms -RSB- .
8103776	0	IL-2	62,66	IFN_gamma	78,87	IL-2	IFN gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Vasoactive intestinal peptide downregulates the expression of IL-2 but not of IFN_gamma from stimulated murine T lymphocytes .
8294138	0	IL-2	56,60	IFN_gamma	61,70	IL-2	IFN gamma	3558	3458	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|linked linked|nsubjpass|END_ENTITY	Activation of human monocyte/macrophage cytotoxicity by IL-2 / IFN_gamma is linked to increased expression of an antitumor receptor with specificity for acetylated mannose .
8580531	0	IL-2	35,39	IFN_gamma	63,72	IL-2	IFN gamma	116562(Tax:10116)	25712(Tax:10116)	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	Opposite effects of interleukin-2 -LRB- IL-2 -RRB- and interferon_gamma -LRB- IFN_gamma -RRB- on rat atria contractility .
10464704	0	IL-2	39,43	IL-1	92,96	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY gene-modified|nsubj|responses gene-modified|nmod|cyclophosphamide cyclophosphamide|amod|END_ENTITY	Enhanced antitumor immune responses of IL-2 gene-modified tumor vaccine by combination with IL-1 and low dose cyclophosphamide .
10479400	0	IL-2	89,93	IL-1	97,101	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY mitogen-activated|nmod|induction mitogen-activated|nmod|END_ENTITY	Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1 .
1309558	0	IL-2	66,70	IL-1	48,52	IL-2	IL-1	3558	3553	Gene	Gene	production|compound|START_ENTITY induction|nmod|production induction|compound|END_ENTITY	The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production .
1337985	0	IL-2	18,22	IL-1	0,4	IL-2	IL-1	3558	3552	Gene	Gene	synergy|nmod|START_ENTITY synergy|compound|END_ENTITY	IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-alpha and beta -LRB- lymphotoxin -RRB- .
1533149	0	IL-2	111,115	IL-1	85,89	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Similar co-stimulation requirements of CD4 + and CD8 + primary T helper cells : role of IL-1 and IL-6 in inducing IL-2 secretion and subsequent proliferation .
1692959	0	IL-2	74,78	IL-1	55,59	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|appos|END_ENTITY	A role for protein kinase C activity in interleukin-1 -LRB- IL-1 -RRB- induction of IL-2 gene expression but not in IL-1 signal transduction .
1699593	0	IL-2	42,46	IL-1	0,4	IL-2	IL-1	3558	3552	Gene	Gene	induced|compound|START_ENTITY regulators|nmod|induced END_ENTITY|nmod|regulators	IL-1 and IL-4 as reciprocal regulators of IL-2 induced lymphocyte cytotoxicity .
2424621	5	IL-2	816,820	IL-1	810,814	IL-2	IL-1	3558	3552	Gene	Gene	BCGF|appos|START_ENTITY BCGF|compound|END_ENTITY	The fraction of small B cells was incubated with IL-1 , IL-2 , Interferon-gamma , Interferon-alpha , BCGF , or BCDF , and cell size changes , RNA synthesis , DNA synthesis , or supernatant immunoglobulin -LRB- Ig -RRB- production were measured .
2466890	0	IL-2	105,109	IL-1	83,87	IL-2	IL-1	3558	3552	Gene	Gene	secretion|nmod|START_ENTITY require|nmod|secretion require|dobj|END_ENTITY	Helper-independent CD8 + cytotoxic T lymphocytes express IL-1 receptors and require IL-1 for secretion of IL-2 .
2786909	0	IL-2	27,31	IL-1	0,4	IL-2	IL-1	3558	3552	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-1 induces high affinity IL-2 receptor expression of CD4-8 - thymocytes .
2831272	0	IL-2	21,25	IL-1	122,126	IL-2	IL-1	3558	3552	Gene	Gene	Increased|nmod|START_ENTITY expressed|nsubjpass|Increased expressed|nmod|END_ENTITY	Increased binding of IL-2 and increased IL-2_receptor mRNA synthesis are expressed by an NK-like cell line in response to IL-1 .
2844906	0	IL-2	19,23	IL-1	0,4	IL-2	IL-1	3558	3552	Gene	Gene	production|compound|START_ENTITY signaling|nmod|production END_ENTITY|acl|signaling	IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis .
3097425	1	IL-2	83,87	IL-1	75,79	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the radioprotective effects of IL-1 to IL-2 , GM-CSF and IFN_gamma .
3115645	0	IL-2	52,56	IL-1	46,50	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	production|compound|START_ENTITY responsiveness|nsubj|production responsiveness|nmod|effects effects|nmod|sodium_thiomalate sodium_thiomalate|nmod|END_ENTITY	In vitro effects of gold sodium_thiomalate on IL-1 , IL-2 production , IL-2 receptor expression and IL-2 responsiveness in thymocytes and peripheral blood mononuclear cells .
6335676	0	IL-2	51,55	IL-1	26,30	IL-2	IL-1	16183(Tax:10090)	3552	Gene	Gene	interleukin-1|appos|START_ENTITY interleukin-1|appos|END_ENTITY	Effects of interleukin-1 -LRB- IL-1 -RRB- and interleukin-2 -LRB- IL-2 -RRB- on the in vivo growth and differentiation of progenitors of natural killer -LRB- NK -RRB- cells .
7506580	0	IL-2	208,212	IL-1	202,206	IL-2	IL-1	3558	3552	Gene	Gene	M-CSF|amod|START_ENTITY M-CSF|amod|END_ENTITY	Hematopoietic recovery following high-dose combined alkylating-agent chemotherapy and autologous bone marrow support in patients in phase-I clinical trials of colony-stimulating factors : G-CSF , GM-CSF , IL-1 , IL-2 , M-CSF .
8820364	0	IL-2	26,30	IL-1	0,4	IL-2	IL-1	3558	3552	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	IL-1 and TNF-alpha but no IL-2 expression is found in squamous_cell_carcinomas of the head_and_neck by RT-PCR .
9130006	0	IL-2	147,151	IL-1	141,145	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	TNF|appos|START_ENTITY TNF|compound|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1 , IL-2 , IL-6 , TNF , CSF activity in normal mice .
9808178	0	IL-2	85,89	IL-1	29,33	IL-2	IL-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	production|dep|START_ENTITY receptor-associated|nmod|production receptor-associated|nsubj|Effects Effects|nmod|overexpression overexpression|nmod|END_ENTITY	Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation , IL-2 production and stress-activated protein kinases in the murine T cell line EL4 .
10232394	0	IL-2	43,47	IL-10	77,82	IL-2	IL-10	116562(Tax:10116)	25325(Tax:10116)	Gene	Gene	production|compound|START_ENTITY down-regulation|nmod|production independent|nsubj|down-regulation independent|nmod|END_ENTITY	Prostaglandin_E2 down-regulation of T cell IL-2 production is independent of IL-10 during gram-negative sepsis .
12030433	0	IL-2	14,18	IL-10	43,48	IL-2	IL-10	3558	3586	Gene	Gene	Th1|appos|START_ENTITY Th1|dep|END_ENTITY	Shift in Th1 -LRB- IL-2 and IFN-gamma -RRB- and Th2 -LRB- IL-10 and IL-4 -RRB- cytokine mRNA balance within two new histological main-types of rheumatoid-arthritis -LRB- RA -RRB- .
17144099	0	IL-2	38,42	IL-10	31,36	IL-2	IL-10	3558	3586	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
17392576	0	IL-2	164,168	IL-10	202,207	IL-2	IL-10	3558	3586	Gene	Gene	IL-8|compound|START_ENTITY IL-8|appos|IL-13 IL-13|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
18023521	0	IL-2	0,4	IL-10	48,53	IL-2	IL-10	3558	3586	Gene	Gene	activation|compound|START_ENTITY enhances|nsubj|activation enhances|dobj|production production|nmod|END_ENTITY	IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells , HOZOT .
18407603	0	IL-2	19,23	IL-10	24,29	IL-2	IL-10	116562(Tax:10116)	25325(Tax:10116)	Gene	Gene	changes|nmod|START_ENTITY changes|dep|END_ENTITY	Dynamic changes of IL-2 / IL-10 , sFas and expression of Fas in intestinal mucosa in rats with acute_necrotizing_pancreatitis .
18582534	0	IL-2	19,23	IL-10	25,30	IL-2	IL-10	3558	3586	Gene	Gene	START_ENTITY|dep|IL-4 IL-4|compound|END_ENTITY	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
18768844	0	IL-2	67,71	IL-10	124,129	IL-2	IL-10	3558	3586	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nmod|enhancer enhancer|nmod|locus locus|compound|END_ENTITY	The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus .
18768844	0	IL-2	67,71	IL-10	18,23	IL-2	IL-10	3558	3586	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|production production|nmod|END_ENTITY	The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus .
18972297	0	IL-2	17,21	IL-10	0,5	IL-2	IL-10	3558	3586	Gene	Gene	IL-12|appos|START_ENTITY IL-12|compound|END_ENTITY	IL-10 , TGF-beta , IL-2 , IL-12 , and IFN-gamma cytokine gene polymorphisms in asthma .
25272942	0	IL-2	26,30	IL-10	38,43	IL-2	IL-10	3558	3586	Gene	Gene	IFN-gamma|dep|START_ENTITY IFN-gamma|dep|IL-17 IL-17|dep|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
25953611	0	IL-2	136,140	IL-10	156,161	IL-2	IL-10	3558	3586	Gene	Gene	results|compound|START_ENTITY results|nmod|production production|compound|END_ENTITY	In autoimmune_hepatitis_type_1 or the autoimmune_hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression .
7520376	0	IL-2	10,14	IL-10	106,111	IL-2	IL-10	3558	3586	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|effect effect|nmod|effect effect|compound|END_ENTITY	Effect of IL-2 on immunoglobulin production by anti-CD40-activated human B cells : synergistic effect with IL-10 and antagonistic effect with IL-4 .
7827283	0	IL-2	108,112	IL-10	48,53	IL-2	IL-10	3558	3586	Gene	Gene	synergy|nmod|START_ENTITY suppression|nmod|synergy role|nmod|suppression Suppression|dep|role Suppression|nmod|response response|nmod|END_ENTITY	Suppression of the allogeneic response by human IL-10 : a critical role for suppression of a synergy between IL-2 and TNF-alpha .
8015314	0	IL-2	85,89	IL-10	130,135	IL-2	IL-10	16183(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8069928	0	IL-2	116,120	IL-10	33,38	IL-2	IL-10	3558	3586	Gene	Gene	expression|amod|START_ENTITY synergizes|nmod|expression interplay|dep|synergizes interplay|nmod|interleukin-10 interleukin-10|appos|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
8069928	0	IL-2	59,63	IL-10	33,38	IL-2	IL-10	3558	3586	Gene	Gene	interleukin-10|appos|START_ENTITY interleukin-10|appos|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
8228801	0	IL-2	60,64	IL-10	16,21	IL-2	IL-10	3558	3586	Gene	Gene	receptors|compound|START_ENTITY upregulates|dobj|receptors upregulates|nsubj|Interleukin_10 Interleukin_10|appos|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes .
8312229	0	IL-2	64,68	IL-10	0,5	IL-2	IL-10	3558	3586	Gene	Gene	starved|nmod|START_ENTITY cells|acl|starved death|nmod|cells inhibits|dobj|death inhibits|nsubj|END_ENTITY	IL-10 inhibits apoptotic cell death in human T cells starved of IL-2 .
8569177	0	IL-2	106,110	IL-10	124,129	IL-2	IL-10	16183(Tax:10090)	16153(Tax:10090)	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8617936	0	IL-2	22,26	IL-10	57,62	IL-2	IL-10	3558	3586	Gene	Gene	stimuli|compound|START_ENTITY synergizes|nmod|stimuli synergizes|advcl|inducing inducing|dobj|production production|compound|END_ENTITY	IL-12 synergizes with IL-2 and other stimuli in inducing IL-10 production by human T cells .
8622992	0	IL-2	25,29	IL-10	61,66	IL-2	IL-10	3558	3586	Gene	Gene	interleukin|appos|START_ENTITY END_ENTITY|nsubj|interleukin	Comparative interleukin -LRB- IL-2 -RRB- / interferon IFN-gamma and IL-4 / IL-10 responses during acute infection of macaques inoculated with attenuated nef-truncated or pathogenic SICmac251 virus .
9510161	0	IL-2	66,70	IL-10	14,19	IL-2	IL-10	3558	3586	Gene	Gene	IL-12|compound|START_ENTITY stimulated|nmod|IL-12 stimulated|nsubj|Production Production|nmod|END_ENTITY	Production of IL-10 by human natural killer cells stimulated with IL-2 and/or IL-12 .
9916879	0	IL-2	85,89	IL-10	0,5	IL-2	IL-10	16183(Tax:10090)	16153(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY transfer|dep|inhibition transfer|compound|END_ENTITY	IL-10 gene transfer to intracranial 9L glioma : tumor inhibition and cooperation with IL-2 .
17392576	0	IL-2	164,168	IL-13	209,214	IL-2	IL-13	3558	3596	Gene	Gene	IL-8|compound|START_ENTITY IL-8|appos|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
10072521	0	IL-2	96,100	IL-15	16,21	IL-2	IL-15	116562(Tax:10116)	25670(Tax:10116)	Gene	Gene	replace|nmod|START_ENTITY inability|acl|replace role|dep|inability role|nmod|END_ENTITY	A novel role of IL-15 in the development of osteoclasts : inability to replace its activity with IL-2 .
10491011	0	IL-2	198,202	IL-15	15,20	IL-2	IL-15	3558	3600	Gene	Gene	receptor|amod|START_ENTITY directed|nmod|receptor antibody|acl|directed therapy|nmod|antibody implications|nmod|therapy Involvement|dep|implications Involvement|nmod|spastic_paraparesis spastic_paraparesis|amod|END_ENTITY	Involvement of IL-15 in the pathogenesis of human T lymphotropic virus type I-associated myelopathy/tropical spastic_paraparesis : implications for therapy with a monoclonal antibody directed to the IL-2 / 15R beta receptor .
10820241	0	IL-2	61,65	IL-15	66,71	IL-2	IL-15	3558	3600	Gene	Gene	delivers|xcomp|START_ENTITY expression|acl:relcl|delivers expression|parataxis|allows allows|nsubj|signals signals|compound|END_ENTITY	Constitutive expression of a chimeric receptor that delivers IL-2 / IL-15 signals allows antigen-independent proliferation of CD8 + CD44high but not other T cells .
12370344	0	IL-2	155,159	IL-15	160,165	IL-2	IL-15	16183(Tax:10090)	16168(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Enforced expression of Bcl-2 restores the number of NK cells , but does not rescue the impaired development of NKT cells or intraepithelial lymphocytes , in IL-2 / IL-15 receptor beta-chain-deficient mice .
15308379	0	IL-2	21,25	IL-15	0,5	IL-2	IL-15	708017(Tax:9544)	699616(Tax:9544)	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	IL-15 is superior to IL-2 in the generation of long-lived antigen specific memory CD4 and CD8 T cells in rhesus_macaques .
15353479	0	IL-2	23,27	IL-15	55,60	IL-2	IL-15	3558	3600	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice .
15893691	0	IL-2	14,18	IL-15	19,24	IL-2	IL-15	3558	3600	Gene	Gene	START_ENTITY|parataxis|enhance enhance|nsubj|induction induction|compound|END_ENTITY	Combinational IL-2 / IL-15 induction does not further enhance IL-15-induced lymphokine-activated killer cell cytotoxicity against human leukemia/lymphoma cells .
18573173	0	IL-2	39,43	IL-15	45,50	IL-2	IL-15	16183(Tax:10090)	16168(Tax:10090)	Gene	Gene	treatment|compound|START_ENTITY treatment|dep|END_ENTITY	Expanded donor natural killer cell and IL-2 , IL-15 treatment efficacy in allogeneic hematopoietic stem cell transplantation .
19198835	0	IL-2	205,209	IL-15	97,102	IL-2	IL-15	16183(Tax:10090)	16168(Tax:10090)	Gene	Gene	culture|nmod|START_ENTITY inducing|advcl|culture capable|advcl|inducing cells|amod|capable yield|nmod|cells increases|dobj|yield increases|nsubj|Incubation Incubation|nmod|lymphocytes lymphocytes|acl|activated activated|nmod|ionomycin ionomycin|nmod|END_ENTITY	Incubation of antigen-sensitized T lymphocytes activated with bryostatin_1 + ionomycin in IL-7 _ + _ IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2 .
21518488	0	IL-2	21,25	IL-15	26,31	IL-2	IL-15	3558	3600	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	-LSB- Cytotoxic effect of IL-2 / IL-15 stimulated cord blood derived NK cells on K562/Jurkat cell lines -RSB- .
21867635	0	IL-2	53,57	IL-15	58,63	IL-2	IL-15	3558	3600	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	-LSB- Expression of perforin in cord blood NK cells after IL-2 / IL-15 stimulation and its relation with cytotoxicity -RSB- .
23328843	0	IL-2	0,4	IL-15	5,10	IL-2	IL-15	3558	3600	Gene	Gene	START_ENTITY|appos|activate activate|nsubj|END_ENTITY	IL-2 / IL-15 activate the human clonally restricted KIR3DL1 reverse promoter .
23805138	0	IL-2	76,80	IL-15	0,5	IL-2	IL-15	16183(Tax:10090)	16168(Tax:10090)	Gene	Gene	Levels|compound|START_ENTITY Face|nmod|Levels Accrual|nmod|Face Accrual|compound|END_ENTITY	IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels .
24139475	0	IL-2	52,56	IL-15	90,95	IL-2	IL-15	373958(Tax:9031)	395258(Tax:9031)	Gene	Gene	signal|compound|START_ENTITY fusion|nmod|signal cytokine|nmod|fusion Construction|nmod|cytokine peptide|nsubj|Construction peptide|xcomp|mature mature|dobj|END_ENTITY	Construction of novel cytokine by fusion of chicken IL-2 signal peptide to mature chicken IL-15 and comparison of the adjuvant effects by DNA immunization against Eimeria challenge .
7641685	0	IL-2	115,119	IL-15	38,43	IL-2	IL-15	16183(Tax:10090)	16168(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY chain|nmod|receptor related|nmod|chain protein|acl:relcl|related protein|compound|END_ENTITY	Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor .
7759955	0	IL-2	88,92	IL-15	0,5	IL-2	IL-15	3558	3600	Gene	Gene	shares|nmod|START_ENTITY factor|acl:relcl|shares END_ENTITY|appos|factor	IL-15 , a novel T cell growth factor that shares activities and receptor components with IL-2 .
8568232	1	IL-2	149,153	IL-15	82,87	IL-2	IL-15	3558	3600	Gene	Gene	stable|nmod|START_ENTITY _|ccomp|stable END_ENTITY|dep|_	The IL-15 / beta/gamma _ c receptor-ligand complex is less stable than the IL-2 / beta/gamma _ c receptor-ligand complex .
9596675	0	IL-2	39,43	IL-15	123,128	IL-2	IL-15	3558	3600	Gene	Gene	signal|compound|START_ENTITY replace|dobj|signal replace|nmod|lines lines|dep|expression expression|nmod|cells cells|compound|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- can replace the IL-2 signal in IL-2-dependent adult_T-cell_leukemia -LRB- ATL -RRB- cell lines : expression of IL-15 receptor alpha on ATL cells .
9596675	0	IL-2	39,43	IL-15	16,21	IL-2	IL-15	3558	3600	Gene	Gene	signal|compound|START_ENTITY replace|dobj|signal replace|nsubj|Interleukin-15 Interleukin-15|appos|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- can replace the IL-2 signal in IL-2-dependent adult_T-cell_leukemia -LRB- ATL -RRB- cell lines : expression of IL-15 receptor alpha on ATL cells .
22461525	0	IL-2	47,51	IL-17	55,60	IL-2	IL-17	3558	3605	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|cells cells|amod|END_ENTITY	Heparin-binding hemagglutinin induces IFN-y -LRB- + -RRB- IL-2 -LRB- + -RRB- IL-17 -LRB- + -RRB- multifunctional CD4 -LRB- + -RRB- T cells during latent but not active tuberculosis_disease .
25272942	0	IL-2	26,30	IL-17	45,50	IL-2	IL-17	3558	3605	Gene	Gene	IFN-gamma|dep|START_ENTITY IFN-gamma|dep|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
14522096	0	IL-2	32,36	IL-1B	17,22	IL-2	IL-1B	3558	3553	Gene	Gene	IL-10|dep|START_ENTITY IL-10|compound|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
14522096	0	IL-2	32,36	IL-1RN	24,30	IL-2	IL-1RN	3558	3557	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
1969882	0	IL-2	99,103	IL-1_alpha	29,39	IL-2	IL-1 alpha	16183(Tax:10090)	16175(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Growth-promoting activity of IL-1_alpha , IL-6 , and tumor_necrosis_factor-alpha in combination with IL-2 , IL-4 , or IL-7 on murine thymocytes .
3143761	0	IL-2	0,4	IL-1_alpha	34,44	IL-2	IL-1 alpha	3558	3552	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	IL-2 stimulates the production of IL-1_alpha and IL-1_beta by human peripheral blood mononuclear cells .
8562579	3	IL-2	519,523	IL-1_beta	508,517	IL-2	IL-1 beta	3558	3553	Gene	Gene	IL-2_receptor|dep|START_ENTITY IL-2_receptor|compound|END_ENTITY	In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls -LRB- tumor_necrosis_factor_alpha - TNF_alpha ; interleukins IL-1_beta , IL-2 , IL-6 , soluble IL-2_receptor -RRB- .
14655147	0	IL-2	43,47	IL-1alpha	32,41	IL-2	IL-1alpha	3558	3552	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Tissue expression of cytokines -LRB- IL-1alpha , IL-2 , IL-6 , IL-12 , TNF-alpha -RRB- in B-cell_lymphomas in children .
9776110	0	IL-2	75,79	IL-1alpha	38,47	IL-2	IL-1alpha	3558	3552	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|TNF-alpha TNF-alpha|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
24659294	0	IL-2	55,59	IL-1b	48,53	IL-2	IL-1b	3558	3553	Gene	Gene	IL-4|dep|START_ENTITY IL-4|compound|END_ENTITY	Effect of rotation and immobilization stress on IL-1b , IL-2 , IL-4 , and IFN-y production by splenocytes under opiate receptor blockade in vivo .
16489252	0	IL-2	31,35	IL-1beta	21,29	IL-2	IL-1beta	3558	3553	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
9262280	0	IL-2	43,47	IL-1beta	33,41	IL-2	IL-1beta	3558	3553	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Seminal cytokine concentrations -LRB- IL-1beta , IL-2 , IL-6 , sR IL-2 , sR IL-6 -RRB- , semen parameters and blood hormonal status in male_infertility .
9262280	0	IL-2	58,62	IL-1beta	33,41	IL-2	IL-1beta	3558	3553	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Seminal cytokine concentrations -LRB- IL-1beta , IL-2 , IL-6 , sR IL-2 , sR IL-6 -RRB- , semen parameters and blood hormonal status in male_infertility .
10713343	0	IL-2	16,20	IL-2	96,100	IL-2	IL-2	373958(Tax:9031)	373958(Tax:9031)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of chicken IL-2 on gammadelta T-cells and Eimeria acervulina-induced changes in intestinal IL-2 mRNA expression and gammadelta T-cells .
10713343	0	IL-2	96,100	IL-2	16,20	IL-2	IL-2	373958(Tax:9031)	373958(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of chicken IL-2 on gammadelta T-cells and Eimeria acervulina-induced changes in intestinal IL-2 mRNA expression and gammadelta T-cells .
12665687	0	IL-2	131,135	IL-2	148,152	IL-2	IL-2	3558	3558	Gene	Gene	START_ENTITY|acl|followed followed|nmod|END_ENTITY	Treatment of chronic_myeloid_leukemia with autologous transplantation using peripheral blood stem cells or bone marrow cultured in IL-2 followed by IL-2 , GM-CSF , and IFN-alpha administration .
12665687	0	IL-2	148,152	IL-2	131,135	IL-2	IL-2	3558	3558	Gene	Gene	followed|nmod|START_ENTITY END_ENTITY|acl|followed	Treatment of chronic_myeloid_leukemia with autologous transplantation using peripheral blood stem cells or bone marrow cultured in IL-2 followed by IL-2 , GM-CSF , and IFN-alpha administration .
1467362	0	IL-2	70,74	IL-2	75,79	IL-2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	proliferation|amod|START_ENTITY proliferation|compound|END_ENTITY	A VLA-4 alpha-chain specific monoclonal antibody enhances CD3-induced IL-2 / IL-2 receptor-dependent T-cell proliferation .
1467362	0	IL-2	75,79	IL-2	70,74	IL-2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	proliferation|compound|START_ENTITY proliferation|amod|END_ENTITY	A VLA-4 alpha-chain specific monoclonal antibody enhances CD3-induced IL-2 / IL-2 receptor-dependent T-cell proliferation .
16911870	0	IL-2	65,69	IL-2	70,74	IL-2	IL-2	3558	3558	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Both integrated and differential regulation of components of the IL-2 / IL-2 receptor system .
16911870	0	IL-2	70,74	IL-2	65,69	IL-2	IL-2	3558	3558	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Both integrated and differential regulation of components of the IL-2 / IL-2 receptor system .
17664293	0	IL-2	73,77	IL-2	83,87	IL-2	IL-2	3558	3558	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Naive CD8 + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo .
17664293	0	IL-2	83,87	IL-2	73,77	IL-2	IL-2	3558	3558	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	Naive CD8 + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo .
19501156	0	IL-2	69,73	IL-2	74,78	IL-2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Green tea EGCG suppresses T cell proliferation through impairment of IL-2 / IL-2 receptor signaling .
19501156	0	IL-2	74,78	IL-2	69,73	IL-2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Green tea EGCG suppresses T cell proliferation through impairment of IL-2 / IL-2 receptor signaling .
25962156	0	IL-2	108,112	IL-2	113,117	IL-2	IL-2	3558	3558	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
25962156	0	IL-2	113,117	IL-2	108,112	IL-2	IL-2	3558	3558	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8 + T Cells by Maximizing Autocrine IL-2 / IL-2 Receptor Signaling .
8069928	0	IL-2	116,120	IL-2	59,63	IL-2	IL-2	3558	3558	Gene	Gene	expression|amod|START_ENTITY synergizes|nmod|expression interplay|dep|synergizes interplay|nmod|interleukin-10 interleukin-10|appos|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
8069928	0	IL-2	59,63	IL-2	116,120	IL-2	IL-2	3558	3558	Gene	Gene	interleukin-10|appos|START_ENTITY interplay|nmod|interleukin-10 interplay|dep|synergizes synergizes|nmod|expression expression|amod|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
9262280	0	IL-2	43,47	IL-2	58,62	IL-2	IL-2	3558	3558	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Seminal cytokine concentrations -LRB- IL-1beta , IL-2 , IL-6 , sR IL-2 , sR IL-6 -RRB- , semen parameters and blood hormonal status in male_infertility .
9262280	0	IL-2	58,62	IL-2	43,47	IL-2	IL-2	3558	3558	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Seminal cytokine concentrations -LRB- IL-1beta , IL-2 , IL-6 , sR IL-2 , sR IL-6 -RRB- , semen parameters and blood hormonal status in male_infertility .
22442347	0	IL-2	22,26	IL-21	0,5	IL-2	IL-21	16183(Tax:10090)	60505(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis .
22027907	0	IL-2	0,4	IL-24	54,59	IL-2	IL-24	3558	11009	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells .
2110211	0	IL-2	48,52	IL-2R	53,58	IL-2	IL-2R	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	Intrathymic radioresistant stem cells follow an IL-2 / IL-2R pathway during thymic regeneration after sublethal irradiation .
3133411	0	IL-2	80,84	IL-2R	39,44	IL-2	IL-2R	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the soluble murine IL-2R and estimation of its affinity for IL-2 .
8268974	0	IL-2	16,20	IL-2R	22,27	IL-2	IL-2R	3558	3559	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	Relationship of IL-2 , IL-2R -LRB- CD25 + -RRB- , soluble IL-2R and IL-4 with disease activity in SLE patients .
11156399	0	IL-2	149,153	IL-2Ralpha	154,164	IL-2	IL-2Ralpha	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	IL-2Ralpha-Directed monoclonal antibodies provide effective therapy in a murine model of adult_T-cell_leukemia by a mechanism other than blockade of IL-2 / IL-2Ralpha interaction .
12649439	0	IL-2	148,152	IL-2Ralpha	60,70	IL-2	IL-2Ralpha	3558	3559	Gene	Gene	inhibit|dobj|START_ENTITY characterization|acl:relcl|inhibit characterization|nmod|interleukin-2 interleukin-2|nmod|complexes complexes|nmod|component component|compound|END_ENTITY	NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component , and with low molecular weight compounds that inhibit the IL-2 / IL-Ralpha interaction .
11131153	0	IL-2	0,4	IL-2Rbeta	32,41	IL-2	IL-2Rbeta	3558	3560	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	IL-2 induces the association of IL-2Rbeta , lyn , and MAP kinase ERK-1 in human neutrophils .
1668858	0	IL-2	58,62	IL-2_receptor	26,39	IL-2	IL-2 receptor	3558	3560	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and release of IL-2_receptor and production of IL-2 by activated T lymphocyte subsets .
2469650	0	IL-2	42,46	IL-2_receptor	67,80	IL-2	IL-2 receptor	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	binding|amod|START_ENTITY sites|amod|binding sites|nmod|complex complex|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
11478799	0	IL-2	24,28	IL-2_receptor_alpha	56,75	IL-2	IL-2 receptor alpha	3558	3559	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of IL-2 and IL-15 on expression of IL-2_receptor_alpha .
2279736	0	IL-2	0,4	IL-2_receptor_alpha	83,102	IL-2	IL-2 receptor alpha	100302458(Tax:9986)	3559	Gene	Gene	receptors|compound|START_ENTITY receptors|acl|expressing expressing|dobj|chain chain|compound|END_ENTITY	IL-2 receptors on rabbit T-cell lines and their transfectants expressing the human IL-2_receptor_alpha chain .
8896456	0	IL-2	3,7	IL-2_receptor_alpha	38,57	IL-2	IL-2 receptor alpha	3558	3559	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|compound|END_ENTITY	An IL-2 response element in the human IL-2_receptor_alpha chain promoter is a composite element that binds Stat5 , Elf-1 , HMG-I -LRB- Y -RRB- and a GATA family protein .
9079703	0	IL-2	15,19	IL-2_receptor_alpha	47,66	IL-2	IL-2 receptor alpha	3558	3559	Gene	Gene	Interleukin-2|appos|START_ENTITY Interleukin-2|dep|induction induction|nmod|gene gene|compound|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- - mediated induction of the IL-2_receptor_alpha chain gene .
10201960	0	IL-2	88,92	IL-4	107,111	IL-2	IL-4	3558	3565	Gene	Gene	express|nmod|START_ENTITY express|nmod|END_ENTITY	Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 .
10224467	0	IL-2	56,60	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	chain|compound|START_ENTITY expression|nmod|chain inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits human CD8 T cell expression of the common IL-2 receptor gamma chain .
10457402	0	IL-2	52,56	IL-4	58,62	IL-2	IL-4	3558	3565	Gene	Gene	IFNgamma|dep|START_ENTITY IFNgamma|dep|END_ENTITY	Peripheral T lymphocyte cytokine profile -LRB- IFNgamma , IL-2 , IL-4 -RRB- and CD30 expression/release during measles_infection .
10497110	0	IL-2	53,57	IL-4	15,19	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY levels|nmod|mRNA levels|nmod|mRNA mRNA|compound|END_ENTITY	High levels of IL-4 and IL-10 mRNA and low levels of IL-2 , IL-9 and IFN-gamma mRNA in MuLV-induced lymphomas .
10525317	0	IL-2	37,41	IL-4	66,70	IL-2	IL-4	3558	3565	Gene	Gene	detection|appos|START_ENTITY _|nsubj|detection _|dobj|cytokines cytokines|appos|END_ENTITY	Flow cytometric detection of type 1 -LRB- IL-2 , IFN-gamma -RRB- _ and_type_2 -LRB- IL-4 , IL-5 -RRB- cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid_arthritis , allergic_asthma and atopic_dermatitis .
10984195	0	IL-2	8,12	IL-4	26,30	IL-2	IL-4	3558	3565	Gene	Gene	elevated|nsubj|START_ENTITY elevated|dobj|IL-6 IL-6|compound|END_ENTITY	Reduced IL-2 but elevated IL-4 , IL-6 , and IgE serum levels in patients with cerebral_infarction during the acute stage .
11991671	0	IL-2	115,119	IL-4	120,124	IL-2	IL-4	3558	3565	Gene	Gene	gamma_chain|compound|START_ENTITY gamma_chain|compound|END_ENTITY	Endogenous interferon-alpha production by differentiating human monocytes regulates expression and function of the IL-2 / IL-4 receptor gamma_chain .
12534941	0	IL-2	64,68	IL-4	0,4	IL-2	IL-4	116562(Tax:10116)	287287(Tax:10116)	Gene	Gene	confers|nsubj|START_ENTITY +|parataxis|confers +|nsubj|END_ENTITY	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
1349533	0	IL-2	84,88	IL-4	75,79	IL-2	IL-4	3558	3565	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Interleukin _ -LRB- IL -RRB- -4 production by human T cells : differential regulation of IL-4 vs. IL-2 production .
1362565	0	IL-2	92,96	IL-4	97,101	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	induce|dobj|START_ENTITY antigen-presenting_cells|acl|induce presentation|nmod|antigen-presenting_cells presentation|parataxis|regulated regulated|nsubjpass|production production|compound|END_ENTITY	Antigen presentation by murine splenic , but not hepatic , antigen-presenting_cells to induce IL-2 / IL-4 production from immune T cells is regulated by interactions between LFA-1 / ICAM-1 .
1431136	0	IL-2	16,20	IL-4	0,4	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY influences|dobj|production influences|nsubj|END_ENTITY	IL-4 influences IL-2 production and granulomatous_inflammation in murine schistosomiasis mansoni .
14522096	0	IL-2	32,36	IL-4	38,42	IL-2	IL-4	3558	3565	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
1531844	0	IL-2	69,73	IL-4	0,4	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced cytokine|dobj|expression cytokine|nsubj|suppresses suppresses|compound|END_ENTITY	IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages .
1588041	0	IL-2	13,17	IL-4	0,4	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes .
1674955	0	IL-2	14,18	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	synthesis|compound|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
17392576	0	IL-2	164,168	IL-4	170,174	IL-2	IL-4	3558	3565	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
1824774	0	IL-2	15,19	IL-4	63,67	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	Suppression|nmod|START_ENTITY Suppression|acl|stimulated stimulated|nmod|END_ENTITY	Suppression by IL-2 of IgE production by B cells stimulated by IL-4 .
1827817	0	IL-2	15,19	IL-4	0,4	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	IL-4 increases IL-2 production by T cells in response to accessory cell-independent stimuli .
1907310	1	IL-2	137,141	IL-4	122,126	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|mRNA mRNA|compound|END_ENTITY	I. IL-4 mRNA , not IL-2 mRNA , is abundant in the granulomatous livers , mesenteric lymph nodes , and spleens of infected mice .
1940368	0	IL-2	44,48	IL-4	0,4	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	IL-4 inhibits the costimulatory activity of IL-2 or picolinic_acid but not of lipopolysaccharide on IFN-gamma-treated macrophages .
1968430	1	IL-2	114,118	IL-4	167,171	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	secreting|dobj|START_ENTITY clones|acl|secreting give|nsubj|clones Evidence|dep|give rise|nsubj|Evidence rise|nmod|clones clones|acl:relcl|secrete secrete|dobj|END_ENTITY	Evidence that clones secreting IL-2 and IL-4 give rise to clones which secrete only IL-4 .
1968925	0	IL-2	14,18	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells .
2102812	0	IL-2	55,59	IL-4	22,26	IL-2	IL-4	3558	3565	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of IL-4 on human B-cell response to IL-2 .
2105854	0	IL-2	0,4	IL-4	55,59	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	have|nsubj|START_ENTITY have|dobj|effects effects|nmod|END_ENTITY	IL-2 , IL-6 , and IFN-gamma have distinct effects on the IL-4 plus PMA-induced proliferation of thymocyte subpopulations .
2117636	0	IL-2	73,77	IL-4	29,33	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	Generation|dep|START_ENTITY Generation|nmod|interleukin_4 interleukin_4|appos|END_ENTITY	Generation of interleukin_4 -LRB- IL-4 -RRB- - producing cells in vivo and in vitro : IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells .
2129798	0	IL-2	96,100	IL-4	51,55	IL-2	IL-4	3558	3565	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Functional and phenotypic modifications induced by IL-4 , as single agent or in combination with IL-2 , on PBMC preactivated in vivo by alpha-interferon + interleukin-2 therapy .
2143207	1	IL-2	46,50	IL-4	67,71	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|production production|compound|END_ENTITY	IL-2 is required for IL-4 production .
2329278	0	IL-2	33,37	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	receptors|compound|START_ENTITY up-regulation|nmod|receptors blocks|dobj|up-regulation blocks|nsubj|END_ENTITY	IL-4 blocks the up-regulation of IL-2 receptors induced by IL-2 in normal human B cells .
2329278	0	IL-2	59,63	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	induced|nmod|START_ENTITY receptors|acl|induced up-regulation|nmod|receptors blocks|dobj|up-regulation blocks|nsubj|END_ENTITY	IL-4 blocks the up-regulation of IL-2 receptors induced by IL-2 in normal human B cells .
2380552	0	IL-2	46,50	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits the expression of high affinity IL-2 receptors on monoclonal human B cells .
2394464	1	IL-2	103,107	IL-4	165,169	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	induces|advmod|START_ENTITY induces|advcl|secrete secrete|dobj|END_ENTITY	Human , but not mouse , IL-2 induces a functionally immature thymic subset to secrete IL-4 and become CTL .
2397500	0	IL-2	130,134	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	correlates|nmod|START_ENTITY clone|dep|correlates response|nmod|clone acts|nmod|response acts|nsubj|END_ENTITY	IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2 , but not with a modified IL-2_receptor expression .
2397500	0	IL-2	33,37	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	response|compound|START_ENTITY acts|nmod|response acts|nsubj|END_ENTITY	IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2 , but not with a modified IL-2_receptor expression .
25272942	0	IL-2	26,30	IL-4	32,36	IL-2	IL-4	3558	3565	Gene	Gene	IFN-gamma|dep|START_ENTITY IFN-gamma|dep|IL-17 IL-17|compound|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
2654291	0	IL-2	15,19	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	induction|compound|START_ENTITY regulates|dobj|induction regulates|nsubj|END_ENTITY	IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes .
2893823	0	IL-2	32,36	IL-4	69,73	IL-2	IL-4	3558	3565	Gene	Gene	Proliferation|nmod|START_ENTITY Proliferation|dep|END_ENTITY	Proliferation and production of IL-2 and B_cell_stimulatory_factor_1 / IL-4 in early fetal thymocytes by activation through Thy-1 and CD3 .
3265652	0	IL-2	57,61	IL-4	18,22	IL-2	IL-4	3558	3565	Gene	Gene	induction|nmod|START_ENTITY suppresses|dobj|induction suppresses|nsubj|END_ENTITY	Human recombinant IL-4 suppresses the induction of human IL-2 induced lymphokine activated killer -LRB- LAK -RRB- activity .
7520376	0	IL-2	10,14	IL-4	141,145	IL-2	IL-4	3558	3565	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|effect effect|nmod|effect effect|nmod|END_ENTITY	Effect of IL-2 on immunoglobulin production by anti-CD40-activated human B cells : synergistic effect with IL-10 and antagonistic effect with IL-4 .
7621236	0	IL-2	98,102	IL-4	6,10	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY therapy|nmod|combination enhances|parataxis|therapy enhances|nsubj|delivery delivery|compound|END_ENTITY	Local IL-4 delivery enhances immune reactivity to murine tumors : gene therapy in combination with IL-2 .
7819141	0	IL-2	88,92	IL-4	18,22	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	release|compound|START_ENTITY decreasing|dobj|release cAMP|advcl|decreasing cAMP|dobj|END_ENTITY	cAMP up-regulates IL-4 and IL-5 production from activated CD4 + T cells while decreasing IL-2 release and NF-AT induction .
8015314	0	IL-2	85,89	IL-4	125,129	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|dep|release release|nmod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8035820	0	IL-2	78,82	IL-4	114,118	IL-2	IL-4	3558	3565	Gene	Gene	receptor|appos|START_ENTITY region|nmod|receptor role|nmod|region Evidence|nmod|role gamma|nsubj|Evidence gamma|dobj|chain chain|nmod|END_ENTITY	Evidence for a critical role for the cytoplasmic region of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma chain in IL-2 , IL-4 , and IL-7 signalling .
8231167	0	IL-2	14,18	IL-4	0,4	IL-2	IL-4	3558	3565	Gene	Gene	induction|compound|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	IL-4 inhibits IL-2 induction of LAK cytotoxicity in lymphocytes from a variety of lymphoid tissues .
8270872	0	IL-2	46,50	IL-4	107,111	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|appos|START_ENTITY costimulation|nmod|production plays|nsubj|costimulation plays|dobj|role role|acl|priming priming|nmod|production production|compound|END_ENTITY	CD28-mediated costimulation of interleukin_2 -LRB- IL-2 -RRB- production plays a critical role in T cell priming for IL-4 and interferon_gamma production .
8352529	0	IL-2	0,4	IL-4	63,67	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	IL-2 inhibits the induction of systemic antitumour immunity by IL-4 in the peritumoural treatment of experimental melanoma .
8569177	0	IL-2	106,110	IL-4	112,116	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8621905	0	IL-2	42,46	IL-4	49,53	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	dexamethasone|nmod|START_ENTITY dexamethasone|dep|END_ENTITY	Differential activity of dexamethasone on IL-2 - , IL-4 - , or IL-9-induced proliferation of murine factor-dependent T cell lines .
8658052	0	IL-2	58,62	IL-4	64,68	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|appos|production production|compound|END_ENTITY	Fibronectin co-stimulates via the alpha 5 beta 1 receptor IL-2 , IL-4 production by splenic , granuloma lymphocytes of Schistosoma_mansoni infected mice .
9557697	0	IL-2	261,265	IL-4	110,114	IL-2	IL-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	interferon|compound|START_ENTITY levels|nmod|interferon presence|nmod|levels diminished|nmod|presence inhibit|advcl|diminished inhibit|nsubj|vaccinia_virus vaccinia_virus|acl|coexpressing coexpressing|dobj|protein protein|nmod|_ _|appos|END_ENTITY	Recombinant vaccinia_virus coexpressing the F protein of respiratory_syncytial_virus _ -LRB- RSV -RRB- and interleukin-4 -LRB- IL-4 -RRB- does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes , whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon .
9558115	0	IL-2	19,23	IL-4	72,76	IL-2	IL-4	3558	3565	Gene	Gene	gamma-chain|compound|START_ENTITY Involvement|nmod|gamma-chain Involvement|nmod|control control|nmod|END_ENTITY	Involvement of the IL-2 receptor gamma-chain -LRB- gammac -RRB- in the control by IL-4 of human monocyte and macrophage proinflammatory mediator production .
10329845	0	IL-2	113,117	IL-5	31,35	IL-2	IL-5	3558	3567	Gene	Gene	synthesis|compound|START_ENTITY regulated|nmod|synthesis T|parataxis|regulated T|nsubj|control control|nmod|gene gene|compound|END_ENTITY	Transcriptional control of the IL-5 gene by human helper T cells : IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis .
10329845	0	IL-2	113,117	IL-5	66,70	IL-2	IL-5	3558	3567	Gene	Gene	synthesis|compound|START_ENTITY regulated|nmod|synthesis regulated|nsubjpass|synthesis synthesis|compound|END_ENTITY	Transcriptional control of the IL-5 gene by human helper T cells : IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis .
10525317	0	IL-2	37,41	IL-5	72,76	IL-2	IL-5	3558	3567	Gene	Gene	detection|appos|START_ENTITY _|nsubj|detection _|dobj|cytokines cytokines|appos|IL-4 IL-4|dep|END_ENTITY	Flow cytometric detection of type 1 -LRB- IL-2 , IFN-gamma -RRB- _ and_type_2 -LRB- IL-4 , IL-5 -RRB- cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid_arthritis , allergic_asthma and atopic_dermatitis .
12884295	0	IL-2	102,106	IL-5	15,19	IL-2	IL-5	3558	3567	Gene	Gene	reduced|nmod|START_ENTITY reduced|nsubjpass|Sensitivity Sensitivity|nmod|production production|compound|END_ENTITY	Sensitivity of IL-5 production to the cAMP-dependent pathway in human T cells is reduced by exogenous IL-2 in a phosphoinositide 3-kinase-dependent way .
15214040	0	IL-2	119,123	IL-5	99,103	IL-2	IL-5	3558	3567	Gene	Gene	secrete|nmod|START_ENTITY secrete|xcomp|END_ENTITY	CD4 -LRB- - -RRB- c-kit -LRB- - -RRB- CD3epsilon -LRB- - -RRB- IL-2Ralpha -LRB- + -RRB- Peyer 's patch cells are a novel cell subset which secrete IL-5 in response to IL-2 : implications for their role in IgA production .
17392576	0	IL-2	164,168	IL-5	176,180	IL-2	IL-5	3558	3567	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
1884020	0	IL-2	33,37	IL-5	85,89	IL-2	IL-5	3558	3567	Gene	Gene	Administration|appos|START_ENTITY results|nsubj|Administration results|nmod|concentrations concentrations|nmod|END_ENTITY	Administration of interleukin-2 -LRB- IL-2 -RRB- results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer .
2373861	1	IL-2	91,95	IL-5	78,82	IL-2	IL-5	16183(Tax:10090)	16191(Tax:10090)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	In vivo and in vitro expression of IL-5 mRNA by IL-2 .
8330315	0	IL-2	100,104	IL-5	18,22	IL-2	IL-5	3558	3567	Gene	Gene	presence|nmod|START_ENTITY lymphocytes|nmod|presence augments|nmod|lymphocytes augments|nsubj|END_ENTITY	Recombinant human IL-5 augments immunoglobulin generation by human B lymphocytes in the presence of IL-2 .
8419486	0	IL-2	0,4	IL-5	24,28	IL-2	IL-5	16183(Tax:10090)	16191(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|response response|compound|END_ENTITY	IL-2 contributes to the IL-5 response in granulomas from mice infected with Schistosoma_mansoni .
8982773	0	IL-2	19,23	IL-5	69,73	IL-2	IL-5	3558	3567	Gene	Gene	role|nmod|START_ENTITY role|nmod|transcription transcription|nmod|END_ENTITY	A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones .
9237106	0	IL-2	32,36	IL-5	13,17	IL-2	IL-5	3558	3567	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of IL-5 expression by IL-2 is resistant to the immunosuppressive agents cyclosporin_A and rapamycin .
10984195	0	IL-2	8,12	IL-6	32,36	IL-2	IL-6	3558	3569	Gene	Gene	elevated|nsubj|START_ENTITY elevated|dobj|END_ENTITY	Reduced IL-2 but elevated IL-4 , IL-6 , and IgE serum levels in patients with cerebral_infarction during the acute stage .
11712808	0	IL-2	15,19	IL-6	21,25	IL-2	IL-6	3558	3569	Gene	Gene	START_ENTITY|appos|21-1 21-1|compound|END_ENTITY	Serial urinary IL-2 , IL-6 , IL-8 , TNFalpha , UBC , CYFRA 21-1 and NMP22 during follow-up of patients with bladder_cancer receiving intravesical BCG .
11860226	0	IL-2	84,88	IL-6	30,34	IL-2	IL-6	3558	3569	Gene	Gene	hypersecretion|nmod|START_ENTITY hypersecretion|nsubj|Abrogation Abrogation|nmod|END_ENTITY	Abrogation of surgery-induced IL-6 hypersecretion by presurgical immunotherapy with IL-2 and its importance in the prevention of postoperative_complications .
12125480	0	IL-2	19,23	IL-6	25,29	IL-2	IL-6	3558	3569	Gene	Gene	IL-10|amod|START_ENTITY IL-10|amod|END_ENTITY	Study on cytokines IL-2 , IL-6 , IL-10 in patients of chronic_allergic_rhinitis treated with acupuncture .
1303001	0	IL-2	19,23	IL-6	25,29	IL-2	IL-6	3558	3569	Gene	Gene	production|nmod|START_ENTITY -LSB-|dobj|production -RSB-|advcl|-LSB- -RSB-|nsubj|cells cells|amod|END_ENTITY	-LSB- The production of IL-2 , IL-6 in relation to the functional development of NK cells in human fetal spleens -RSB- .
1438170	0	IL-2	67,71	IL-6	72,76	IL-2	IL-6	3558	3569	Gene	Gene	analysis|nmod|START_ENTITY Overexpression|dep|analysis Overexpression|amod|chimeric chimeric|amod|END_ENTITY	Overexpression and structure -- function analysis of a bioengineered IL-2 / IL-6 chimeric lymphokine .
14522096	0	IL-2	32,36	IL-6	44,48	IL-2	IL-6	3558	3569	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
1469455	0	IL-2	14,18	IL-6	27,31	IL-2	IL-6	3558	3569	Gene	Gene	TNF-alpha|compound|START_ENTITY TNF-alpha|dep|END_ENTITY	Evaluation of IL-2 , sIL2R , IL-6 , TNF-alpha , and IL-1_beta levels in serum and CSF of patients with optic_neuritis .
17144099	0	IL-2	38,42	IL-6	44,48	IL-2	IL-6	3558	3569	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
1730872	0	IL-2	0,4	IL-6	13,17	IL-2	IL-6	3558	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-2 induces IL-6 production in human monocytes .
17392576	0	IL-2	164,168	IL-6	182,186	IL-2	IL-6	3558	3569	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
18490709	0	IL-2	60,64	IL-6	114,118	IL-2	IL-6	3558	3569	Gene	Gene	induced|nmod|START_ENTITY cells|acl|induced resistant|nsubj|cells resistant|nmod|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18582534	0	IL-2	19,23	IL-6	32,36	IL-2	IL-6	3558	3569	Gene	Gene	START_ENTITY|dep|IL-4 IL-4|dep|END_ENTITY	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
21786545	0	IL-2	75,79	IL-6	81,85	IL-2	IL-6	3558	3569	Gene	Gene	IL-1|dep|START_ENTITY IL-1|dep|END_ENTITY	-LSB- Clinical significance and expression of the inflammatory cytokines -LRB- IL-1 , IL-2 , IL-6 and IL-10 -RRB- in blood serum of the patients after total hip replacement -RSB- .
2295801	0	IL-2	0,4	IL-6	68,72	IL-2	IL-6	3558	3569	Gene	Gene	dependence|compound|START_ENTITY differentiation|nsubj|dependence differentiation|nmod|END_ENTITY	IL-2 dependence of the promotion of human B cell differentiation by IL-6 -LRB- BSF-2 -RRB- .
2571638	0	IL-2	37,41	IL-6	0,4	IL-2	IL-6	3558	3569	Gene	Gene	production|compound|START_ENTITY stimulate|dobj|production synergize|xcomp|stimulate synergize|nsubj|END_ENTITY	IL-6 and IL-1 synergize to stimulate IL-2 production and proliferation of peripheral T cells .
3261751	0	IL-2	139,143	IL-6	89,93	IL-2	IL-6	3558	3569	Gene	Gene	monoclonal|nmod|START_ENTITY monoclonal|dobj|END_ENTITY	Cooperation between an anti-T cell -LRB- anti-CD28 -RRB- monoclonal antibody and monocyte-produced IL-6 in the induction of T cell responsiveness to IL-2 .
8409748	0	IL-2	84,88	IL-6	90,94	IL-2	IL-6	3558	3569	Gene	Gene	mRNA|nmod|START_ENTITY synthesis|amod|mRNA synthesis|amod|END_ENTITY	Inhibition of human mononuclear cell proliferation , interleukin synthesis , mRNA for IL-2 , IL-6 , and leukotriene B4 synthesis by a lipoxygenase inhibitor .
8562579	3	IL-2	519,523	IL-6	525,529	IL-2	IL-6	3558	3569	Gene	Gene	IL-2_receptor|dep|START_ENTITY IL-2_receptor|dep|END_ENTITY	In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls -LRB- tumor_necrosis_factor_alpha - TNF_alpha ; interleukins IL-1_beta , IL-2 , IL-6 , soluble IL-2_receptor -RRB- .
8640150	0	IL-2	82,86	IL-6	59,63	IL-2	IL-6	3558	3569	Gene	Gene	monocytes|appos|START_ENTITY monocytes|appos|IL-1_beta IL-1_beta|dep|END_ENTITY	-LSB- Production of selected cytokines by monocytes -LRB- IL-1_beta , IL-6 -RRB- and lymphocytes -LRB- IL-2 , IL-4 -RRB- in peripheral blood of patients with nonallergic bronchial_asthma treated with Broncho-Vaxom -RSB- .
8899186	0	IL-2	87,91	IL-6	8,12	IL-2	IL-6	3558	3569	Gene	Gene	receiving|nmod|START_ENTITY patients|acl|receiving receptors|nmod|patients receptors|compound|END_ENTITY	Soluble IL-6 receptors -LRB- sIL-6R -RRB- in hematological patients receiving immunotherapy with IL-2 / IFN-alpha or donor lymphocytes following bone marrow transplantation .
9130006	0	IL-2	147,151	IL-6	153,157	IL-2	IL-6	16183(Tax:10090)	16193(Tax:10090)	Gene	Gene	TNF|appos|START_ENTITY TNF|appos|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1 , IL-2 , IL-6 , TNF , CSF activity in normal mice .
9776110	0	IL-2	75,79	IL-6	49,53	IL-2	IL-6	3558	3569	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|TNF-alpha TNF-alpha|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
12354940	0	IL-2	0,4	IL-7	26,30	IL-2	IL-7	3558	3574	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|alpha alpha|amod|END_ENTITY	IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes .
15259908	0	IL-2	47,51	IL-7	0,4	IL-2	IL-7	3558	3574	Gene	Gene	immunotherapy|compound|START_ENTITY regulation|dep|immunotherapy END_ENTITY|dep|regulation	IL-7 / IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients .
15259908	0	IL-2	47,51	IL-7	5,9	IL-2	IL-7	3558	3574	Gene	Gene	immunotherapy|compound|START_ENTITY regulation|dep|immunotherapy regulation|compound|END_ENTITY	IL-7 / IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients .
1531763	0	IL-2	82,86	IL-7	0,4	IL-2	IL-7	3558	3574	Gene	Gene	pathway|compound|START_ENTITY precursors|nmod|pathway CD8|dep|precursors induces|parataxis|CD8 induces|nsubj|END_ENTITY	IL-7 induces proliferation of CD3 - / low CD4 - CD8 - human thymocyte precursors by an IL-2 independent pathway .
15577633	0	IL-2	99,103	IL-7	0,4	IL-2	IL-7	3558	3574	Gene	Gene	therapy|compound|START_ENTITY increased|nmod|therapy increased|nsubjpass|levels levels|amod|END_ENTITY	IL-7 and Flt-3L plasma levels are increased during highly active antiretroviral therapy-associated IL-2 therapy .
18981091	0	IL-2	33,37	IL-7	39,43	IL-2	IL-7	3558	3574	Gene	Gene	cytokines|xcomp|START_ENTITY cytokines|ccomp|induce induce|nsubj|END_ENTITY	The common_gamma-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 induce the expression of programmed death-1 and its ligands .
19198835	0	IL-2	205,209	IL-7	90,94	IL-2	IL-7	16183(Tax:10090)	16196(Tax:10090)	Gene	Gene	culture|nmod|START_ENTITY inducing|advcl|culture capable|advcl|inducing cells|amod|capable yield|nmod|cells increases|dobj|yield increases|nsubj|Incubation Incubation|nmod|lymphocytes lymphocytes|acl|activated activated|nmod|ionomycin ionomycin|nmod|IL-15 IL-15|compound|END_ENTITY	Incubation of antigen-sensitized T lymphocytes activated with bryostatin_1 + ionomycin in IL-7 _ + _ IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2 .
19950184	0	IL-2	20,24	IL-7	0,4	IL-2	IL-7	3558	3574	Gene	Gene	cells|amod|START_ENTITY superior|nmod|cells superior|nsubj|END_ENTITY	IL-7 is superior to IL-2 for ex vivo expansion of tumour-specific CD4 -LRB- + -RRB- T cells .
20190192	0	IL-2	31,35	IL-7	0,4	IL-2	IL-7	16183(Tax:10090)	16196(Tax:10090)	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic_lymphoma in immunodeficient mice .
21552852	0	IL-2	78,82	IL-7	128,132	IL-2	IL-7	3558	3574	Gene	Gene	generated|nmod|START_ENTITY generated|parataxis|induced induced|nmod|END_ENTITY	Comparison of adherent lymphokine-activated killer -LRB- a-lak -RRB- cells generated by IL-2 and IL-7 - cellular modifications induced by IL-7 .
22422881	0	IL-2	99,103	IL-7	105,109	IL-2	IL-7	3558	3574	Gene	Gene	cytokines|xcomp|START_ENTITY associated|ccomp|cytokines associated|nsubjpass|END_ENTITY	Antigen-independent induction of Tim-3 expression on human T cells by the common y-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway .
23994891	0	IL-2	53,57	IL-7	33,37	IL-2	IL-7	3558	3574	Gene	Gene	exhibit|compound|START_ENTITY cultured|nmod|exhibit cultured|nmod|END_ENTITY	Cord blood T cells cultured with IL-7 in addition to IL-2 exhibit a higher degree of polyfunctionality and superior proliferation potential .
8128231	0	IL-2	32,36	IL-7	61,65	IL-2	IL-7	3558	3574	Gene	Gene	gamma|compound|START_ENTITY participation|nmod|gamma chain|nsubj|participation chain|nmod|complexes complexes|compound|END_ENTITY	Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes .
8569177	0	IL-2	106,110	IL-7	118,122	IL-2	IL-7	16183(Tax:10090)	16196(Tax:10090)	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8622984	0	IL-2	15,19	IL-7	66,70	IL-2	IL-7	16183(Tax:10090)	16196(Tax:10090)	Gene	Gene	Interleukin_2|appos|START_ENTITY induce|nsubj|Interleukin_2 induce|dobj|receptors receptors|compound|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- and interleukin_7 -LRB- IL-7 -RRB- reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes .
8916956	0	IL-2	23,27	IL-7	30,34	IL-2	IL-7	3558	3574	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|amod|END_ENTITY	Role of interleukin-2 -LRB- IL-2 -RRB- , IL-7 , and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma_c transduced severe combined immunodeficiency X1 bone marrow cells .
20623548	0	IL-2	0,4	IL-7R_alpha	67,78	IL-2	IL-7R alpha	16183(Tax:10090)	16197(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|development development|nmod|cells cells|compound|END_ENTITY	IL-2 is positively involved in the development of colitogenic CD4 + IL-7R_alpha high memory T cells in chronic_colitis .
10570276	0	IL-2	160,164	IL-7Ralpha	10,20	IL-2	IL-7Ralpha	16183(Tax:10090)	16197(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	IL-2Rbeta / IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte -LRB- IEL -RRB- developmental defects of gammac - / - mice : roles for both IL-2 and IL-15 in CD8alphaalpha IEL development .
16489252	0	IL-2	31,35	IL-8	43,47	IL-2	IL-8	3558	3576	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
17222831	0	IL-2	138,142	IL-8	167,171	IL-2	IL-8	3558	3576	Gene	Gene	Interleukin|amod|START_ENTITY Interleukin|acl|END_ENTITY	Interleukin -LRB- IL -RRB- -12 receptor beta1 codon 378 G homozygote and allele , but not IL-1 -LRB- beta-511 promoter , 3953 exon 5 , receptor antagonist -RRB- , IL-2 114 , IL-4-590 intron 3 , IL-8 3 ' - UTR 2767 , and IL-18 105 , are associated with higher susceptibility to leiomyoma .
8144938	0	IL-2	88,92	IL-8	13,17	IL-2	IL-8	3558	3576	Gene	Gene	neutrophils|nmod|START_ENTITY neutrophils|nsubj|Induction Induction|nmod|expression expression|compound|END_ENTITY	Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2 .
8360487	0	IL-2	0,4	IL-8	43,47	IL-2	IL-8	3558	3576	Gene	Gene	up-regulates|compound|START_ENTITY suppresses|nsubj|up-regulates suppresses|dobj|expression expression|compound|END_ENTITY	IL-2 up-regulates but IFN-gamma suppresses IL-8 expression in human monocytes .
8397255	0	IL-2	55,59	IL-8	47,51	IL-2	IL-8	3558	3576	Gene	Gene	immunotherapy|compound|START_ENTITY Induction|nmod|immunotherapy Induction|nmod|END_ENTITY	Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1_receptor_antagonist and soluble tumor necrosis factor receptor -LRB- p75 -RRB- chimera .
10714558	0	IL-2	35,39	Interleukin-18	0,14	IL-2	Interleukin-18	16183(Tax:10090)	16173(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interleukin-18 in combination with IL-2 enhances natural killer cell activity without inducing large amounts of IFN-gamma in vivo .
11221875	0	IL-2	39,43	Interleukin-18	0,14	IL-2	Interleukin-18	3558	3606	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Interleukin-18 -LRB- IL-18 -RRB- synergizes with IL-2 to enhance cytotoxicity , interferon-gamma production , and expansion of natural killer cells .
16805135	0	IL-2	15,19	Interleukin-2	0,13	IL-2	Interleukin-2	3558	3558	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- expression in livers of patients with chronic hepatitis_C_virus _ -LRB- HCV -RRB- infection .
6231106	0	IL-2	15,19	Interleukin_2	0,13	IL-2	Interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- activity during tumor growth : IL-2 production kinetics , absorption of and responses to exogenous IL-2 .
7528775	0	IL-2	127,131	JAK2	59,63	IL-2	JAK2	3558	3717	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin 12 -LRB- IL-12 -RRB- induces tyrosine phosphorylation of JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 .
1658591	0	IL-2	34,38	LAK	50,53	IL-2	LAK	3558	80216	Gene	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	-LSB- Adopted immunochemotherapy using IL-2 and spleen LAK cell -- randomized study -RSB- .
2031145	0	IL-2	111,115	LAK	55,58	IL-2	LAK	16183(Tax:10090)	320982(Tax:10090)	Gene	Gene	influence|nmod|START_ENTITY precursors|nmod|influence precursors|nmod|cells cells|nmod|activity activity|compound|END_ENTITY	Differentiation of macrophage precursors to cells with LAK activity under the influence of CSF-1 and high dose IL-2 .
2390269	0	IL-2	71,75	LAK	20,23	IL-2	LAK	3558	80216	Gene	Gene	using|dobj|START_ENTITY Generation|acl|using Generation|nmod|cells cells|compound|END_ENTITY	Generation of human LAK cells in tissue culture bags using recombinant IL-2 and serum free medium .
3262092	0	IL-2	35,39	LAK	59,62	IL-2	LAK	3558	80216	Gene	Gene	lymphokine|appos|START_ENTITY Heterogeneity|nmod|lymphokine Heterogeneity|dep|killer killer|appos|END_ENTITY	Heterogeneity of human lymphokine -LRB- IL-2 -RRB- - activated killer -LRB- LAK -RRB- precursors and regulation of their LAK induction by blood monocytes .
3262092	0	IL-2	35,39	LAK	99,102	IL-2	LAK	3558	80216	Gene	Gene	lymphokine|appos|START_ENTITY Heterogeneity|nmod|lymphokine Heterogeneity|dep|killer killer|dep|precursors precursors|nmod|END_ENTITY	Heterogeneity of human lymphokine -LRB- IL-2 -RRB- - activated killer -LRB- LAK -RRB- precursors and regulation of their LAK induction by blood monocytes .
8110993	0	IL-2	48,52	LAK	61,64	IL-2	LAK	16183(Tax:10090)	71481(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Asialo-positive cells are overexpressed whereas IL-2 induced LAK activity is impaired in mice hyperimmunized with an immunomodulating mycobacterial fraction .
12193230	0	IL-2	38,42	LFA-1	94,99	IL-2	LFA-1	16183(Tax:10090)	16414(Tax:10090)	Gene	Gene	cytokines|appos|START_ENTITY cytokines|appos|VCAM-1 VCAM-1|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
23185455	0	IL-2	22,26	MCPIP1	0,6	IL-2	MCPIP1	3558	80149	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway .
10229820	0	IL-2	44,48	NF-kappaB	89,98	IL-2	NF-kappaB	3558	4790	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- enhances IL-2 production and nuclear translocation of NF-kappaB in FGF_receptor-bearing Jurkat T cells .
15322180	0	IL-2	18,22	NF-kappaB	75,84	IL-2	NF-kappaB	3558	4790	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|advcl|preventing preventing|dobj|activation activation|amod|END_ENTITY	Ceramide inhibits IL-2 production by preventing protein_kinase_C-dependent NF-kappaB activation : possible role in protein_kinase_Ctheta regulation .
9584155	0	IL-2	118,122	NF-kappaB	142,151	IL-2	NF-kappaB	3558	4790	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression Mechanism|dobj|regulation Mechanism|nmod|END_ENTITY	Mechanism responsible for T-cell antigen receptor - and CD28 - or interleukin_1 _ -LRB- IL-1 -RRB- receptor-initiated regulation of IL-2 gene expression by NF-kappaB .
17470640	0	IL-2	25,29	NF90	0,4	IL-2	NF90	16183(Tax:10090)	16201(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF90 regulates inducible IL-2 gene expression in T cells .
18097023	0	IL-2	36,40	NF90	18,22	IL-2	NF90	3558	3609	Gene	Gene	mRNA|compound|START_ENTITY stabilize|dobj|mRNA export|acl|stabilize export|nmod|END_ENTITY	Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation .
23924068	8	IL-2	1547,1551	NFAT2	1526,1531	IL-2	NFAT2	3558	4772	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Although NFAT2 mRNA levels were unaffected , chromatin immunoprecipitation -LRB- ChIP -RRB- for NFAT2 indicated decreased NFAT2 binding at the IL-2 promoter in suppressed Th cells .
9808178	0	IL-2	85,89	NFkappaB	64,72	IL-2	NFkappaB	16183(Tax:10090)	18033(Tax:10090)	Gene	Gene	production|dep|START_ENTITY production|compound|END_ENTITY	Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation , IL-2 production and stress-activated protein kinases in the murine T cell line EL4 .
8413330	0	IL-2	0,4	NK-TR	37,42	IL-2	NK-TR	3558	4820	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism .
9989503	0	IL-2	54,58	Nmi	26,29	IL-2	Nmi	3558	9111	Gene	Gene	signaling|amod|START_ENTITY association|nmod|signaling association|nmod|END_ENTITY	Functional association of Nmi with Stat5 and Stat1 in IL-2 - and IFNgamma-mediated signaling .
11035066	0	IL-2	46,50	P1-30	19,24	IL-2	P1-30	3558	5934	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	IL-2R_beta agonist P1-30 acts in synergy with IL-2 , IL-4 , IL-9 , and IL-15 : biological and molecular effects .
1420599	0	IL-2	155,159	P75	151,154	IL-2	P75	3558	3560	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Tumor recognition and lytic competence of IL-2-activated lymphocytes : regulation of both antibody-independent and - dependent cellular cytotoxicity via P75 IL-2 receptor .
23451206	0	IL-2	40,44	PDE4B	28,33	IL-2	PDE4B	3558	5142	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid_cancer cells .
17144099	0	IL-2	38,42	PDGF-B	50,56	IL-2	PDGF-B	3558	5155	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
26729804	0	IL-2	58,62	PMCA4	42,47	IL-2	PMCA4	3558	493	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling .
9311917	0	IL-2	48,52	Rap1	85,89	IL-2	Rap1	3558	5906	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Maintenance of human T cell anergy : blocking of IL-2 gene transcription by activated Rap1 .
12543077	0	IL-2	15,19	SHP2	0,4	IL-2	SHP2	3558	5781	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	SHP2 regulates IL-2 induced MAPK activation , but not Stat3 or Stat5 tyrosine phosphorylation , in cutaneous_T_cell_lymphoma cells .
10556800	0	IL-2	28,32	SP1	41,44	IL-2	SP1	3558	6667	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3 .
12681450	0	IL-2	0,4	STAT3	36,41	IL-2	STAT3	3558	6774	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells .
9886399	0	IL-2	0,4	STAT4	13,18	IL-2	STAT4	3558	6775	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	IL-2 induces STAT4 activation in primary NK cells and NK cell lines , but not in T cells .
10815800	0	IL-2	0,4	STAT5	88,93	IL-2	STAT5	3558	6776	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|factors factors|compound|END_ENTITY	IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells .
17130555	0	IL-2	60,64	STAT5	65,70	IL-2	STAT5	3558	6776	Gene	Gene	START_ENTITY|dep|dependent dependent|dep|END_ENTITY	Upregulation of Foxp3 expression in mouse and human Treg is IL-2 / STAT5 dependent : implications for the NOD STAT5B mutation in diabetes pathogenesis .
17182565	0	IL-2	0,4	STAT5	29,34	IL-2	STAT5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells .
18023521	0	IL-2	0,4	STAT5	19,24	IL-2	STAT5	3558	6776	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells , HOZOT .
19675167	0	IL-2	66,70	STAT5	85,90	IL-2	STAT5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	autoimmunity|nmod|START_ENTITY survival|nmod|autoimmunity survival|parataxis|signaling signaling|nsubj|END_ENTITY	Self-peptides prolong survival in murine autoimmunity via reduced IL-2 / IL-7-mediated STAT5 signaling , CD8 coreceptor , and V alpha 2 down-regulation .
21329987	0	IL-2	72,76	STAT5	77,82	IL-2	STAT5	3558	6776	Gene	Gene	signalling|compound|START_ENTITY signalling|compound|END_ENTITY	Mechanisms involved in the expansion of Tregs during pregnancy : role of IL-2 / STAT5 signalling .
23451206	0	IL-2	40,44	STAT5	53,58	IL-2	STAT5	3558	6776	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid_cancer cells .
24587342	0	IL-2	41,45	STAT5	10,15	IL-2	STAT5	3558	6776	Gene	Gene	regulated|nmod|START_ENTITY gene|acl|regulated gene|compound|END_ENTITY	FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells .
24829413	0	IL-2	0,4	STAT5	20,25	IL-2	STAT5	3558	6776	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	IL-2 phosphorylates STAT5 to drive IFN-y production and activation of human dendritic cells .
9395528	0	IL-2	107,111	STAT5	15,20	IL-2	STAT5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	alpha|amod|START_ENTITY transcription|amod|alpha stimulation|nmod|transcription mediates|dobj|stimulation mediates|nsubj|Interaction Interaction|nmod|dimers dimers|nummod|END_ENTITY	Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin_2 -LRB- IL-2 -RRB- stimulation of IL-2 receptor alpha gene transcription .
9395528	0	IL-2	86,90	STAT5	15,20	IL-2	STAT5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	stimulation|appos|START_ENTITY mediates|dobj|stimulation mediates|nsubj|Interaction Interaction|nmod|dimers dimers|nummod|END_ENTITY	Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin_2 -LRB- IL-2 -RRB- stimulation of IL-2 receptor alpha gene transcription .
9398404	0	IL-2	0,4	STAT5	43,48	IL-2	STAT5	3558	6776	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|heterodimerization heterodimerization|nmod|isoforms isoforms|nummod|END_ENTITY	IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts .
9531312	0	IL-2	29,33	STAT5	43,48	IL-2	STAT5	3558	6776	Gene	Gene	growth|nmod|START_ENTITY Regulation|nmod|growth Regulation|dep|role role|nmod|END_ENTITY	Regulation of cell growth by IL-2 : role of STAT5 in protection from apoptosis but not in cell cycle progression .
17571248	0	IL-2	0,4	Sgk1	21,25	IL-2	Sgk1	3558	6446	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney_cancer cells .
21955384	0	IL-2	14,18	Siva	38,42	IL-2	Siva	3558	10572	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells .
10679091	0	IL-2	4,8	Stat5	142,147	IL-2	Stat5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY promotes|nsubj|receptor promotes|nmod|domain domain|nmod|END_ENTITY	The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc , bcl-2 , and bcl-x genes through the trans-activation domain of Stat5 .
11160217	0	IL-2	74,78	Stat5	0,5	IL-2	Stat5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Stat5 and Sp1 regulate transcription of the cyclin_D2 gene in response to IL-2 .
11784295	0	IL-2	47,51	Stat5	26,31	IL-2	Stat5	3558	6776	Gene	Gene	DNA-binding|nmod|START_ENTITY DNA-binding|compound|END_ENTITY	Interferon-alpha inhibits Stat5 DNA-binding in IL-2 stimulated primary T-lymphocytes .
12407017	0	IL-2	72,76	Stat5	26,31	IL-2	Stat5	3558	6776	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|phosphorylation phosphorylation|nmod|proteins proteins|amod|END_ENTITY	Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2 .
23395551	0	IL-2	101,105	Stat5	106,111	IL-2	Stat5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	/|compound|START_ENTITY inhibition|nmod|/ mice|nmod|inhibition autoimmune_T_cell-driven_retinal_disease|nmod|mice END_ENTITY|amod|autoimmune_T_cell-driven_retinal_disease	SIRT1 activation protects against autoimmune_T_cell-driven_retinal_disease in mice via inhibition of IL-2 / Stat5 signaling .
8896456	0	IL-2	3,7	Stat5	107,112	IL-2	Stat5	3558	6776	Gene	Gene	element|compound|START_ENTITY element|nsubj|element element|acl:relcl|binds binds|dobj|END_ENTITY	An IL-2 response element in the human IL-2_receptor_alpha chain promoter is a composite element that binds Stat5 , Elf-1 , HMG-I -LRB- Y -RRB- and a GATA family protein .
9989503	0	IL-2	54,58	Stat5	35,40	IL-2	Stat5	3558	6776	Gene	Gene	signaling|amod|START_ENTITY association|nmod|signaling association|nmod|END_ENTITY	Functional association of Nmi with Stat5 and Stat1 in IL-2 - and IFNgamma-mediated signaling .
1375246	0	IL-2	21,25	Substance_P	0,11	IL-2	Substance P	3558	6863	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Substance_P enhances IL-2 expression in activated human T cells .
11880152	0	IL-2	104,108	T-cell-growth-factor	56,76	IL-2	T-cell-growth-factor	116562(Tax:10116)	116562(Tax:10116)	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	Propagation of lewis rat encephalitogenic T cell lines : T-cell-growth-factor is superior to recombinant IL-2 .
14610621	0	IL-2	39,43	T-cell_receptor	23,38	IL-2	T-cell receptor	3558	6962	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	A soluble single-chain T-cell_receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity .
17277105	0	IL-2	0,4	TGF-beta	22,30	IL-2	TGF-beta	16183(Tax:10090)	21803(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
18209044	0	IL-2	18,22	TGF-beta	0,8	IL-2	TGF-beta	3558	7040	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	TGF-beta inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction .
10936508	0	IL-2	36,40	TGF-beta_1	0,10	IL-2	TGF-beta 1	3558	7040	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGF-beta_1 differentially regulates IL-2 expression and -LSB- 3H -RSB- - thymidine incorporation in CD3 epsilon mAb - and CD28 mAb-activated splenocytes and thymocytes .
15034041	0	IL-2	46,50	TGF-beta_1	23,33	IL-2	TGF-beta 1	16183(Tax:10090)	21803(Tax:10090)	Gene	Gene	production|compound|START_ENTITY suppress|dobj|production essential|xcomp|suppress essential|nmod|END_ENTITY	Smad3 is essential for TGF-beta_1 to suppress IL-2 production and TCR-induced proliferation , but not IL-2-induced proliferation .
7948746	0	IL-2	112,116	TGF-beta_1	35,45	IL-2	TGF-beta 1	3558	7040	Gene	Gene	production|amod|START_ENTITY suppression|nmod|production PBMC|nmod|suppression synthesis|nmod|PBMC inhibits|dobj|synthesis inhibits|nsubj|Transforming_growth_factor-beta_1 Transforming_growth_factor-beta_1|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production .
8811326	0	IL-2	103,107	TGF-beta_1	69,79	IL-2	TGF-beta 1	3558	7040	Gene	Gene	production|compound|START_ENTITY stimulate|dobj|production stimulate|dobj|transforming_growth_factor-beta_1 transforming_growth_factor-beta_1|appos|END_ENTITY	Elevated glucose levels stimulate transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- , suppress interleukin IL-2 , IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells .
16517754	0	IL-2	17,21	TLR-7	40,45	IL-2	TLR-7	3558	51284	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Sensitization of IL-2 signaling through TLR-7 enhances B_lymphoma cell immunogenicity .
25145773	0	IL-2	10,14	TNF-Alpha	140,149	IL-2	TNF-Alpha	3558	7124	Gene	Gene	Controls|nsubj|START_ENTITY Controls|nmod|Treated Treated|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Exogenous IL-2 Controls the Balance in Th1 , Th17 , and Treg Cell Distribution in Patients with Progressive Rheumatoid_Arthritis Treated with TNF-Alpha Inhibitors .
24938899	0	IL-2	88,92	TNF-a	75,80	IL-2	TNF-a	116562(Tax:10116)	24835(Tax:10116)	Gene	Gene	IFN-y|appos|START_ENTITY IFN-y|compound|END_ENTITY	Analysis of Influence of Baicalin Joint Resveratrol Retention Enema on the TNF-a , SIgA , IL-2 , IFN-y of Rats with Respiratory_Syncytial_Virus Infection .
10390079	0	IL-2	28,32	TNF-alpha	17,26	IL-2	TNF-alpha	3558	7124	Gene	Gene	IFNs|dep|START_ENTITY IFNs|dep|END_ENTITY	Cytokines -LRB- IFNs , TNF-alpha , IL-2 and IL-12 -RRB- and animal models of cancer .
11427636	0	IL-2	84,88	TNF-alpha	52,61	IL-2	TNF-alpha	3558	7124	Gene	Gene	system|compound|START_ENTITY activation|dep|system activation|nmod|system system|amod|END_ENTITY	Quantitative flow cytometry shows activation of the TNF-alpha system but not of the IL-2 system at the single cell level in renal replacement therapy .
1337985	0	IL-2	18,22	TNF-alpha	93,102	IL-2	TNF-alpha	3558	7124	Gene	Gene	synergy|nmod|START_ENTITY mediated|nsubjpass|synergy mediated|nmod|lymphotoxin lymphotoxin|compound|END_ENTITY	IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-alpha and beta -LRB- lymphotoxin -RRB- .
14655147	0	IL-2	43,47	TNF-alpha	62,71	IL-2	TNF-alpha	3558	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Tissue expression of cytokines -LRB- IL-1alpha , IL-2 , IL-6 , IL-12 , TNF-alpha -RRB- in B-cell_lymphomas in children .
15806975	0	IL-2	135,139	TNF-alpha	109,118	IL-2	TNF-alpha	3558	7124	Gene	Gene	levels|appos|START_ENTITY interleukin-2|dobj|levels interleukin-2|nsubj|efficacy efficacy|appos|interferon-gamma interferon-gamma|appos|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
16489252	0	IL-2	31,35	TNF-alpha	49,58	IL-2	TNF-alpha	3558	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
2065356	0	IL-2	0,4	TNF-alpha	20,29	IL-2	TNF-alpha	3558	7124	Gene	Gene	dose|compound|START_ENTITY regulates|nsubj|dose regulates|dobj|transcription transcription|amod|END_ENTITY	IL-2 dose regulates TNF-alpha mRNA transcription and protein secretion in human peripheral blood lymphocytes .
7544321	0	IL-2	56,60	TNF-alpha	109,118	IL-2	TNF-alpha	16183(Tax:10090)	21926(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|xcomp|promote promote|dobj|synthesis synthesis|nmod|END_ENTITY	Tumor-derived factor synergizes with IFN-gamma and LPS , IL-2 or TNF-alpha to promote macrophage synthesis of TNF-alpha and TNF_receptors for autocrine induction of nitric_oxide synthase and enhanced nitric_oxide-mediated tumor_cytotoxicity .
8930418	0	IL-2	20,24	TNF-alpha	9,18	IL-2	TNF-alpha	3558	7124	Gene	Gene	markers|nsubj|START_ENTITY markers|nmod|END_ENTITY	In vitro TNF-alpha , IL-2 and IFN-gamma production as markers of relapses in multiple_sclerosis .
9776110	0	IL-2	75,79	TNF-alpha	27,36	IL-2	TNF-alpha	3558	7124	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
22675200	0	IL-2	49,53	Toso	0,4	IL-2	Toso	3558	9214	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Toso , a functional IgM receptor , is regulated by IL-2 in T and NK cells .
9840924	0	IL-2	14,18	Tpl-2	0,5	IL-2	Tpl-2	3558	1326	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB .
9864299	0	IL-2	55,59	Transforming_growth_factor-beta_1	0,33	IL-2	Transforming growth factor-beta 1	16183(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- promotes IL-2 mRNA expression through the up-regulation of NF-kappaB , AP-1 and NF-AT in EL4 cells .
1968489	0	IL-2	107,111	Tumor_necrosis_factor-alpha	0,27	IL-2	Tumor necrosis factor-alpha	16183(Tax:10090)	21926(Tax:10090)	Gene	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha and P40 induce day 15 murine fetal thymocyte proliferation in combination with IL-2 .
8099848	0	IL-2	172,176	VIP	84,87	IL-2	VIP	16183(Tax:10090)	22353(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibiting|dobj|production suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	Modulation of T lymphocyte proliferation in mice infected with Schistosoma_mansoni : VIP suppresses mitogen - and antigen-induced T cell proliferation possibly by inhibiting IL-2 production .
7691937	0	IL-2	51,55	Vimentin	0,8	IL-2	Vimentin	16183(Tax:10090)	22352(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Vimentin expression is differentially regulated by IL-2 and IL-4 in murine T cells .
10453520	0	IL-2	25,29	beta-Endorphin	1,15	IL-2	beta-Endorphin	3558	5443	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	-LSB- beta-Endorphin enhances IL-2 and IFN-gamma gene expression in human blood mononuclear cells -RSB- .
22474330	0	IL-2	7,11	c-Fos	42,47	IL-2	c-Fos	3558	2353	Gene	Gene	decision|compound|START_ENTITY decision|acl|making making|nmod|END_ENTITY	Stable IL-2 decision making by endogenous c-Fos amounts in peripheral memory T-helper cells .
8757326	0	IL-2	31,35	c-Fos	83,88	IL-2	c-Fos	3558	2353	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene associated|nsubjpass|transcription associated|nmod|expression expression|nmod|END_ENTITY	Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos , FosB , and JunB in anergic T helper 1 cells .
15337523	0	IL-2	91,95	c-Kit	67,72	IL-2	c-Kit	3558	3815	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Interleukin-2 -LRB- IL-2 -RRB- receptor-betagamma signalling is activated by c-Kit in the absence of IL-2 , or by exogenous IL-2 via JAK3/STAT5 in human_papillomavirus-associated_cervical_cancer .
2143208	0	IL-2	0,4	c-fms	14,19	IL-2	c-fms	3558	1436	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	IL-2 enhances c-fms expression in human monocytes .
1305903	0	IL-2	45,49	c-fos	12,17	IL-2	c-fos	16183(Tax:10090)	14281(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene augments|dobj|expression augments|nsubj|END_ENTITY	Deregulated c-fos augments the expression of IL-2 gene in T cells stimulated with anti-CD3 antibody .
1918970	0	IL-2	36,40	c-fos	0,5	IL-2	c-fos	16183(Tax:10090)	14281(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	c-fos transcriptional activation by IL-2 in mouse CTL-L2 cells is mediated through two distinct signal transduction pathways converging on the same enhancer element .
7560451	0	IL-2	147,151	c-fos	97,102	IL-2	c-fos	16183(Tax:10090)	14281(Tax:10090)	Gene	Gene	sensitivity|nmod|START_ENTITY expression|appos|sensitivity expression|amod|END_ENTITY	Differential cell - and immuno-biological properties of murine B16-F1 and F10 melanomas : oncogene c-fos expression , sensitivity to LAK cells and/or IL-2 , and components of gangliosides .
7568005	0	IL-2	36,40	c-fos	99,104	IL-2	IL-2R	3558	3559	Gene	Gene	receptor|appos|START_ENTITY role|nmod|receptor gamma-chain-associated|nsubj|role gamma-chain-associated|nmod|induction induction|amod|END_ENTITY	Critical role of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc , but not bcl-2 , gene induction .
7930571	0	IL-2	12,16	c-fos	36,41	IL-2	c-fos	16183(Tax:10090)	14281(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Analysis of IL-2 gene regulation in c-fos transgenic_mice .
8468462	1	IL-2	89,93	c-fos	134,139	IL-2	c-fos	3558	2353	Gene	Gene	transcription|compound|START_ENTITY correlates|nsubj|transcription correlates|nmod|synthesis synthesis|amod|END_ENTITY	Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1 .
9027322	0	IL-2	15,19	c-fos	39,44	IL-2	c-fos	3558	2353	Gene	Gene	Interleukin-2|appos|START_ENTITY regulate|nsubj|Interleukin-2 regulate|dobj|expression expression|amod|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- and IL-6 regulate c-fos protooncogene expression in human pituitary_adenoma explants .
10640728	0	IL-2	0,4	common_gamma-chain	88,106	IL-2	common gamma-chain	16183(Tax:10090)	16186(Tax:10090)	Gene	Gene	unresponsiveness|compound|START_ENTITY due|nsubj|unresponsiveness due|xcomp|signaling signaling|nmod|END_ENTITY	IL-2 unresponsiveness in anergic CD4 + T cells is due to defective signaling through the common_gamma-chain of the IL-2 receptor .
10640728	0	IL-2	114,118	common_gamma-chain	88,106	IL-2	common gamma-chain	16183(Tax:10090)	16186(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	IL-2 unresponsiveness in anergic CD4 + T cells is due to defective signaling through the common_gamma-chain of the IL-2 receptor .
10946282	0	IL-2	29,33	common_gamma-chain	101,119	IL-2	common gamma-chain	3558	3561	Gene	Gene	internalization|nmod|START_ENTITY depends|nsubj|internalization depends|nmod|portion portion|nmod|tail tail|nmod|END_ENTITY	Efficient internalization of IL-2 depends on the distal portion of the cytoplasmic tail of the IL-2R common_gamma-chain and a lymphoid cell environment .
18981091	0	IL-2	33,37	common_gamma-chain	4,22	IL-2	common gamma-chain	3558	3561	Gene	Gene	cytokines|xcomp|START_ENTITY cytokines|nsubj|END_ENTITY	The common_gamma-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 induce the expression of programmed death-1 and its ligands .
1967265	0	IL-2	28,32	cyclosporin_A	11,24	IL-2	cyclosporin A	16183(Tax:10090)	1161	Gene	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of cyclosporin_A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic_choriomeningitis_virus .
9724269	0	IL-2	39,43	endothelin-1	13,25	IL-2	endothelin-1	116562(Tax:10116)	24323(Tax:10116)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Induction of endothelin-1 synthesis by IL-2 and its modulation of rat intestinal epithelial cell growth .
9334854	0	IL-2	31,35	hCG	11,14	IL-2	hCG	3558	93659	Gene	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of hCG and beta-hCG on IL-2 and sIL-2R secretion from human peripheral blood mononuclear cells : a dose-response study in vitro .
1692959	0	IL-2	74,78	interleukin-1	40,53	IL-2	interleukin-1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	A role for protein kinase C activity in interleukin-1 -LRB- IL-1 -RRB- induction of IL-2 gene expression but not in IL-1 signal transduction .
10207608	0	IL-2	117,121	interleukin-2	102,115	IL-2	interleukin-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Phospholipase_A2 inhibitors p-bromophenacyl_bromide and arachidonyl_trifluoromethyl_ketone suppressed interleukin-2 -LRB- IL-2 -RRB- expression in murine primary splenocytes .
11809870	0	IL-2	41,45	interleukin-2	26,39	IL-2	interleukin-2	3558	3558	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cannabinol enhancement of interleukin-2 -LRB- IL-2 -RRB- expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity .
1345742	0	IL-2	30,34	interleukin-2	15,28	IL-2	interleukin-2	3558	3558	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	On the role of interleukin-2 -LRB- IL-2 -RRB- in multiple_sclerosis -LRB- MS -RRB- .
15806975	0	IL-2	135,139	interleukin-2	121,134	IL-2	interleukin-2	3558	3558	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
1698421	0	IL-2	26,30	interleukin-2	11,24	IL-2	interleukin-2	3558	3558	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin-2 -LRB- IL-2 -RRB- on human plasma lipid , lipoprotein , and C-reactive_protein .
2009236	0	IL-2	91,95	interleukin-2	67,80	IL-2	interleukin-2	3558	3558	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	Blood_coagulation_abnormalities during adoptive immunotherapy with interleukin-2 -LRB- r-Met Hu IL-2 -LSB- ala 125 -RSB- -RRB- .
20544350	0	IL-2	39,43	interleukin-2	24,37	IL-2	interleukin-2	3558	3558	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Antiapoptotic effect of interleukin-2 -LRB- IL-2 -RRB- in B-CLL cells with low and high affinity IL-2 receptors .
2420701	0	IL-2	37,41	interleukin-2	22,35	IL-2	interleukin-2	3558	3558	Gene	Gene	Inactivation|appos|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human interleukin-2 -LRB- IL-2 -RRB- by alpha 2-macroglobulin-trypsin complexes .
2474592	0	IL-2	46,50	interleukin-2	31,44	IL-2	interleukin-2	3558	3558	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Allergen-specific induction of interleukin-2 -LRB- IL-2 -RRB- responsiveness in lymphocytes from children with asthma .
2787749	0	IL-2	67,71	interleukin-2	43,56	IL-2	interleukin-2	3558	3558	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	Tolerance and effectiveness of recombinant interleukin-2 -LRB- r-met Hu IL-2 -LSB- ala-125 -RSB- -RRB- and lymphokine-activated killer cells in patients with metastatic solid_tumors .
2788180	0	IL-2	46,50	interleukin-2	31,44	IL-2	interleukin-2	3558	3558	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Allergen-specific induction of interleukin-2 -LRB- IL-2 -RRB- responsiveness in lymphocytes from children with asthma .
6609855	0	IL-2	38,42	interleukin-2	23,36	IL-2	interleukin-2	3558	3558	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Decreased synthesis of interleukin-2 -LRB- IL-2 -RRB- in insulin-dependent_diabetes_mellitus .
7591233	0	IL-2	23,27	interleukin-2	8,21	IL-2	interleukin-2	3558	3558	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lack of interleukin-2 -LRB- IL-2 -RRB- expression and selective expression of IL-10 mRNA in human renal_cell_carcinoma .
7621867	0	IL-2	52,56	interleukin-2	36,49	IL-2	interleukin-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Non random activation of endogenous interleukin-2 , -LRB- IL-2 -RRB- , IL-2_receptor alpha and IL-2_receptor beta genes after transfection of mouse fibroblasts with a cDNA for the alpha chain of the human IL-2_receptor .
7907273	0	IL-2	79,83	interleukin-2	48,61	IL-2	interleukin-2	3558	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Progression mechanisms in colon_cancer : soluble interleukin-2 -LRB- IL-2 -RRB- _ receptor , IL-2 plus anti-CD3 proliferative response and tumour stage correlations .
8294403	0	IL-2	58,62	interleukin-2	43,56	IL-2	interleukin-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The adapter protein Shc interacts with the interleukin-2 -LRB- IL-2 -RRB- receptor upon IL-2 stimulation .
8423463	0	IL-2	50,54	interleukin-2	24,37	IL-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	In vivo relationship of interleukin-2 and soluble IL-2 receptor to blood-brain barrier_impairment in patients with active multiple_sclerosis .
8831171	0	IL-2	31,35	interleukin-2	16,29	IL-2	interleukin-2	3558	3558	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	-LSB- Correlation of interleukin-2 -LRB- IL-2 -RRB- responsiveness by egg white-stimulated lymphocytes with hen egg oral provocation test in atopic children -RSB- .
7482719	0	IL-2	60,64	interleukin-6	16,29	IL-2	interleukin-6	3558	3569	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	The relation of interleukin-6 , tumor_necrosis_factor-alpha , IL-2 , and IL-2_receptor levels to cellular rejection , allograft_dysfunction , and clinical events early after cardiac transplantation .
16242788	0	IL-2	36,40	interleukin_2	21,34	IL-2	interleukin 2	3558	3558	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Potentiating role of interleukin_2 -LRB- IL-2 -RRB- receptors in the midbrain periaqueductal gray -LRB- PAG -RRB- upon defensive rage behavior in the cat : role of neurokinin NK -LRB- 1 -RRB- _ receptors .
1854252	0	IL-2	35,39	interleukin_2	20,33	IL-2	interleukin 2	3558	3558	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Randomized study of interleukin_2 -LRB- IL-2 -RRB- alone vs IL-2 plus lymphokine-activated killer cells for treatment of melanoma and renal_cell_cancer .
2450841	0	IL-2	111,115	interleukin_2	27,40	IL-2	interleukin 2	3558	3558	Gene	Gene	_|nmod|START_ENTITY _|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of interleukin_2 -LRB- IL-2 -RRB- _ receptor expression on antigen-specific human T cell clones by IL-2 .
2591452	0	IL-2	21,25	interleukin_2	6,19	IL-2	interleukin 2	3558	3558	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum interleukin_2 -LRB- IL-2 -RRB- levels and prolactin bioactive/radioimmunoassay ratios of women at risk for breast_cancer .
3119713	0	IL-2	57,61	interleukin_2	19,32	IL-2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Internalization of interleukin_2 -LRB- IL-2 -RRB- by high affinity IL-2 receptors is required for the growth of IL-2-dependent T cell lines .
3924455	0	IL-2	63,67	interleukin_2	48,61	IL-2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Characterization of a monoclonal rat anti-mouse interleukin_2 -LRB- IL-2 -RRB- receptor antibody and its use in the biochemical characterization of the murine IL-2 receptor .
6600395	0	IL-2	82,86	interleukin_2	67,80	IL-2	interleukin 2	3558	3558	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Clearance rates and systemic effects of intravenously administered interleukin_2 -LRB- IL-2 -RRB- containing preparations in human subjects .
7568005	0	IL-2	36,40	interleukin_2	21,34	IL-2	interleukin 2	3558	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Critical role of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc , but not bcl-2 , gene induction .
8035820	0	IL-2	78,82	interleukin_2	63,76	IL-2	interleukin 2	3558	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Evidence for a critical role for the cytoplasmic region of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma chain in IL-2 , IL-4 , and IL-7 signalling .
8473495	0	IL-2	60,64	interleukin_2	45,58	IL-2	interleukin 2	3558	3558	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Negative transcriptional regulation of human interleukin_2 -LRB- IL-2 -RRB- gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT .
8662742	0	IL-2	92,96	interleukin_2	77,90	IL-2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin_2 -LRB- IL-2 -RRB- expression in the murine T-cell line , EL4.IL-2 .
10433555	0	IL-2	94,98	lymphotactin	25,37	IL-2	lymphotactin	3558	6375	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Expression of SCM-1alpha / lymphotactin and SCM-1beta in natural killer cells is upregulated by IL-2 and IL-12 .
20935646	0	IL-2	35,39	miR-182	13,20	IL-2	miR-182	3558	406958	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes .
8752938	0	IL-2	119,123	monocyte_chemoattractant_protein-1	154,188	IL-2	monocyte chemoattractant protein-1	3558	6347	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Human fibroblasts express functional IL-2 receptors formed by the IL-2R_alpha - and beta-chain subunits : association of IL-2 binding with secretion of the monocyte_chemoattractant_protein-1 .
2840461	0	IL-2	50,54	ornithine_decarboxylase	14,37	IL-2	ornithine decarboxylase	16183(Tax:10090)	18263(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of ornithine_decarboxylase activity by IL-2 and cyclic_AMP .
11994454	0	IL-2	97,101	p27Kip1	66,73	IL-2	p27Kip1	3558	1027	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|transcription transcription|nmod|END_ENTITY	The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2 .
15249725	0	IL-2	0,4	p38	78,81	IL-2	p38	3558	1432	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	IL-2 and IL-10 production by human CD4 + T cells is differentially regulated by p38 : mode of stimulation-dependent regulation of IL-2 .
1370571	0	IL-2	155,159	p55	131,134	IL-2	p55	3558	3559	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	Immunochemical characterization of antigenic domains on human IL-2 : spatially distinct epitopes are associated with binding to the p55 and p70 subunits of IL-2 receptor .
1370571	0	IL-2	62,66	p55	131,134	IL-2	p55	3558	3559	Gene	Gene	domains|nmod|START_ENTITY characterization|nmod|domains associated|nsubjpass|characterization associated|nmod|receptor receptor|amod|binding binding|nmod|subunits subunits|amod|END_ENTITY	Immunochemical characterization of antigenic domains on human IL-2 : spatially distinct epitopes are associated with binding to the p55 and p70 subunits of IL-2 receptor .
1690471	1	IL-2	91,95	p55	126,129	IL-2	p55	3558	3559	Gene	Gene	Relationships|nmod|START_ENTITY Relationships|nmod|chain chain|amod|END_ENTITY	Relationships to high-affinity IL-2 binding and modulation of the p55 chain .
1717581	0	IL-2	54,58	p55	32,35	IL-2	p55	16183(Tax:10090)	17524(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Structure-function study of the p55 subunit of murine IL-2 receptor by epitope mapping .
2011131	0	IL-2	65,69	p55	19,22	IL-2	p55	16183(Tax:10090)	17524(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY interleukin-2|dobj|expression interleukin-2|nsubj|Induction Induction|nmod|END_ENTITY	Induction of mouse p55 interleukin-2 receptor gene expression by IL-2 and IL-4 and characterization of its transcription initiation sites .
2258612	0	IL-2	107,111	p55	79,82	IL-2	p55	16183(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	IL-2-dependent proliferation of murine T cells requires expression of both the p55 and p70 subunits of the IL-2 receptor .
2469650	0	IL-2	42,46	p55	160,163	IL-2	p55	16183(Tax:10090)	21937(Tax:10090)	Gene	Gene	binding|amod|START_ENTITY sites|amod|binding formation|nmod|sites Studies|nmod|formation Studies|dep|importance importance|nmod|determinant determinant|nmod|subunit subunit|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2469650	0	IL-2	42,46	p55	81,84	IL-2	p55	16183(Tax:10090)	21937(Tax:10090)	Gene	Gene	binding|amod|START_ENTITY sites|amod|binding sites|nmod|complex complex|amod|IL-2_receptor IL-2_receptor|dep|+ +|nummod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2523424	0	IL-2	14,18	p55	69,72	IL-2	p55	16183(Tax:10090)	21937(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY up-regulates|nsubj|Activation up-regulates|dobj|expression expression|nmod|subunit subunit|amod|END_ENTITY	Activation by IL-2 , but not IL-4 , up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2 - _ and_IL-4-dependent T cell lines .
2523424	0	IL-2	88,92	p55	69,72	IL-2	p55	16183(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Activation by IL-2 , but not IL-4 , up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2 - _ and_IL-4-dependent T cell lines .
2897342	0	IL-2	38,42	p55	54,57	IL-2	p55	3558	3559	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors effects|nmod|expression effects|dep|END_ENTITY	Differential effects on expression of IL-2 receptors -LRB- p55 and p70 -RRB- by the HTLV-I pX DNA .
2971378	0	IL-2	43,47	p55	24,27	IL-2	p55	16183(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Nuclear location of the p55 subunit of the IL-2 receptor following activation of the HT-2 T helper cell line .
3116668	0	IL-2	4,8	p70	30,33	IL-2	p70	3558	84959	Gene	Gene	chain|compound|START_ENTITY chain|appos|END_ENTITY	The IL-2 receptor beta chain -LRB- p70 -RRB- : role in mediating signals for LAK , NK , and proliferative activities .
1380801	0	IL-2	59,63	p70_S6_kinase	42,55	IL-2	p70 S6 kinase	3558	6198	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Rapamycin inhibits the phosphorylation of p70_S6_kinase in IL-2 and mitogen-activated human T cells .
15383581	0	IL-2	65,69	p75	38,41	IL-2	p75	3558	3560	Gene	Gene	induction|compound|START_ENTITY costimulator|nmod|induction END_ENTITY|nmod|costimulator	Critical role of TNF receptor type-2 -LRB- p75 -RRB- as a costimulator for IL-2 induction and T cell survival : a functional link to CD28 .
2080985	0	IL-2	115,119	p75	73,76	IL-2	p75	16183(Tax:10090)	21938(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY form|nmod|receptor form|amod|END_ENTITY	A regulatory role for the soluble IL-2 receptor via competition with the p75 cell-surface form of the receptor for IL-2 .
2080985	0	IL-2	34,38	p75	73,76	IL-2	p75	16183(Tax:10090)	21938(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY role|nmod|receptor role|nmod|form form|amod|END_ENTITY	A regulatory role for the soluble IL-2 receptor via competition with the p75 cell-surface form of the receptor for IL-2 .
2106566	0	IL-2	15,19	p75	71,74	IL-2	p75	3558	3560	Gene	Gene	Interleukin_2|appos|START_ENTITY Interleukin_2|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- - induced tyrosine phosphorylation of IL-2_receptor p75 .
2469650	0	IL-2	42,46	p75	87,90	IL-2	p75	16183(Tax:10090)	21938(Tax:10090)	Gene	Gene	binding|amod|START_ENTITY sites|amod|binding sites|nmod|complex complex|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
8318457	0	IL-2	12,16	p75	34,37	IL-2	p75	3558	3560	Gene	Gene	role|nmod|START_ENTITY interaction|nsubj|role interaction|nmod|molecules molecules|amod|END_ENTITY	The role of IL-2 interaction with p75 and p55 receptor molecules in the stimulation of cell proliferation .
8397255	0	IL-2	55,59	p75	189,192	IL-2	p75	3558	7133	Gene	Gene	immunotherapy|compound|START_ENTITY Induction|nmod|immunotherapy Induction|nmod|production production|nmod|chimera chimera|appos|END_ENTITY	Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1_receptor_antagonist and soluble tumor necrosis factor receptor -LRB- p75 -RRB- chimera .
15654770	0	IL-2	31,35	protein_arginine_methyltransferase_5	64,100	IL-2	protein arginine methyltransferase 5	3558	10419	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Arginine methylation regulates IL-2 gene expression : a role for protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- .
2394468	0	IL-2	52,56	serine_protease	20,35	IL-2	serine protease	3558	2147	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|END_ENTITY	A chymotryptic-type serine_protease is required for IL-2 production by Jurkat T cells .
8670878	0	IL-2	18,22	tax	47,50	IL-2	tax	3558	1491938(Tax:11908)	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element .
7800164	0	IL-2	91,95	transferrin	78,89	IL-2	transferrin	3558	7018	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Psychoimmune investigation in obsessive-compulsive_disorder : assays of plasma transferrin , IL-2 and IL-6 receptor , and IL-1_beta and IL-6 concentrations .
15806975	0	IL-2	135,139	tumor_necrosis_factor-alpha	80,107	IL-2	tumor necrosis factor-alpha	3558	7124	Gene	Gene	levels|appos|START_ENTITY interleukin-2|dobj|levels interleukin-2|nsubj|efficacy efficacy|appos|interferon-gamma interferon-gamma|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
7482719	0	IL-2	60,64	tumor_necrosis_factor-alpha	31,58	IL-2	tumor necrosis factor-alpha	3558	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	The relation of interleukin-6 , tumor_necrosis_factor-alpha , IL-2 , and IL-2_receptor levels to cellular rejection , allograft_dysfunction , and clinical events early after cardiac transplantation .
8893810	0	IL-2-inducible_T-cell_kinase	26,54	ITK	61,64	IL-2-inducible T-cell kinase	ITK	3702	3702	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of the human IL-2-inducible_T-cell_kinase gene -LRB- ITK -RRB- to chromosome band 5q34 and the mouse gene -LRB- Itk -RRB- to chromosome 15 by fluorescence in situ hybridization .
19917685	0	IL-2-inducible_T_cell_kinase	91,119	Hematopoietic_lineage_cell-specific_protein_1	0,45	IL-2-inducible T cell kinase	Hematopoietic lineage cell-specific protein 1	3702	3059	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Hematopoietic_lineage_cell-specific_protein_1 is recruited to the immunological synapse by IL-2-inducible_T_cell_kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading .
21158938	0	IL-2-inducible_tyrosine_kinase	18,48	Itk	50,53	IL-2-inducible tyrosine kinase	Itk	16428(Tax:10090)	16428(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Inhibition of the IL-2-inducible_tyrosine_kinase -LRB- Itk -RRB- activity : a new concept for the therapy of inflammatory skin_diseases .
17013900	0	IL-2-receptor_alpha	39,58	LMP1	24,28	IL-2-receptor alpha	LMP1	3559	9260	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Concomitant increase of LMP1 and CD25 -LRB- IL-2-receptor_alpha -RRB- expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3 .
16645593	0	IL-20	24,29	CD11c	39,44	IL-20	CD11c	50604	3687	Gene	Gene	production|nmod|START_ENTITY production|dep|cells cells|amod|END_ENTITY	Prominent production of IL-20 by CD68 + / CD11c + myeloid-derived cells in psoriasis : Gene regulation and cellular effects .
19830738	0	IL-20	32,37	IL-22	18,23	IL-20	IL-22	50604	50616	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	The Th17 cytokine IL-22 induces IL-20 production in keratinocytes : a novel immunological cascade with potential relevance in psoriasis .
23183096	0	IL-20	41,46	interleukin_20	25,39	IL-20	interleukin 20	50604	50604	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of interleukin_20 -LRB- IL-20 -RRB- in patients with ulcerative_colitis .
22019586	0	IL-21	13,18	APCs	32,36	IL-21	APCs	60505(Tax:10090)	20219(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice .
18052963	0	IL-21	0,5	CD25	21,25	IL-21	CD25	60505(Tax:10090)	16184(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	IL-21 modulates CD4 + CD25 + regulatory T-cell homeostasis in experimental_autoimmune_encephalomyelitis .
23402380	0	IL-21	0,5	CD27	32,36	IL-21	CD27	59067	939	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expansion expansion|nmod|tumor tumor|compound|END_ENTITY	IL-21 promotes the expansion of CD27 + CD28 + tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells .
26818544	0	IL-21	50,55	CD27	28,32	IL-21	CD27	59067	939	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
19797296	0	IL-21	0,5	CD28	80,84	IL-21	CD28	59067	940	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28 + CD8 memory T cells throughout the adult age span .
23402380	0	IL-21	0,5	CD28	38,42	IL-21	CD28	59067	940	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expansion expansion|nmod|tumor tumor|compound|END_ENTITY	IL-21 promotes the expansion of CD27 + CD28 + tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells .
17202333	0	IL-21	0,5	CD4	70,73	IL-21	CD4	59067	920	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|suppression suppression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-21 counteracts the regulatory T cell-mediated suppression of human CD4 + T lymphocytes .
17698559	0	IL-21	55,60	CD4	105,108	IL-21	CD4	59067	920	Gene	Gene	START_ENTITY|dep|effect effect|nmod|proliferation proliferation|nmod|subsets subsets|compound|END_ENTITY	Human CD4 + central and effector memory T cells produce IL-21 : effect on cytokine-driven proliferation of CD4 + T cell subsets .
17698559	0	IL-21	55,60	CD4	6,9	IL-21	CD4	59067	920	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	Human CD4 + central and effector memory T cells produce IL-21 : effect on cytokine-driven proliferation of CD4 + T cell subsets .
17947662	0	IL-21	18,23	CD4	91,94	IL-21	CD4	59067	920	Gene	Gene	role|nmod|START_ENTITY role|nmod|collaboration collaboration|compound|END_ENTITY	Essential role of IL-21 in B cell activation , expansion , and plasma cell generation during CD4 + T cell-B cell collaboration .
18052963	0	IL-21	0,5	CD4	16,19	IL-21	CD4	60505(Tax:10090)	12504(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|CD25 CD25|compound|END_ENTITY	IL-21 modulates CD4 + CD25 + regulatory T-cell homeostasis in experimental_autoimmune_encephalomyelitis .
18788946	0	IL-21	32,37	CD4	86,89	IL-21	CD4	59067	920	Gene	Gene	circulating|dobj|START_ENTITY levels|acl|circulating levels|dep|correlation correlation|nmod|counts counts|compound|END_ENTITY	Decreased levels of circulating IL-21 in HIV-infected AIDS patients : correlation with CD4 + T-cell counts .
19139170	0	IL-21	71,76	CD4	89,92	IL-21	CD4	59067	920	Gene	Gene	START_ENTITY|acl|produced produced|nmod|cells cells|compound|END_ENTITY	The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4 + T cells .
19342640	0	IL-21	28,33	CD4	68,71	IL-21	CD4	60505(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY loop|nmod|signaling provoked|nsubj|loop provoked|nmod|CD25 CD25|compound|END_ENTITY	A positive feedback loop of IL-21 signaling provoked by homeostatic CD4 + CD25 - T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice .
21055341	0	IL-21	33,38	CD4	28,31	IL-21	CD4	59067	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	-LSB- Characterization of memory CD4 + IL-21 + T cells in human PBMC -RSB- .
21419052	0	IL-21	13,18	CD4	29,32	IL-21	CD4	59067	920	Gene	Gene	levels|compound|START_ENTITY induced|dobj|levels induced|nmod|END_ENTITY	-LSB- The induced IL-21 levels in CD4 -LRB- + -RRB- T cells of peripheral blood from the different clinical types of patients infected with hepatitis_B_virus -RSB- .
21441456	0	IL-21	0,5	CD4	35,38	IL-21	CD4	60505(Tax:10090)	12504(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|recruitment recruitment|nmod|cells cells|amod|END_ENTITY	IL-21 promotes skin recruitment of CD4 -LRB- + -RRB- cells and drives IFN-y-dependent epidermal_hyperplasia .
22491065	0	IL-21	14,19	CD4	40,43	IL-21	CD4	59067	920	Gene	Gene	production|compound|START_ENTITY triggers|dobj|production triggers|nmod|cells cells|compound|END_ENTITY	IL-6 triggers IL-21 production by human CD4 + T cells to drive STAT3-dependent plasma cell differentiation in B cells .
22723520	0	IL-21	0,5	CD4	84,87	IL-21	CD4	60505(Tax:10090)	12504(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|lupus-like_disease lupus-like_disease|nmod|mechanisms mechanisms|amod|chronic_graft-versus-host_disease chronic_graft-versus-host_disease|nmod|cell cell|compound|END_ENTITY	IL-21 promotes lupus-like_disease in chronic_graft-versus-host_disease through both CD4 T cell - and B cell-intrinsic mechanisms .
23168836	0	IL-21	11,16	CD4	46,49	IL-21	CD4	59067	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV_disease in mice .
23493630	0	IL-21	52,57	CD4	72,75	IL-21	CD4	59067	920	Gene	Gene	production|compound|START_ENTITY reduces|dobj|production reduces|nmod|cells cells|compound|END_ENTITY	Interleukin-6_receptor blockade selectively reduces IL-21 production by CD4 T cells and IgG4 autoantibodies in rheumatoid_arthritis .
24470500	0	IL-21	0,5	CD4	15,18	IL-21	CD4	59067	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|responses responses|compound|END_ENTITY	IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells .
25281860	0	IL-21	61,66	CD4	0,3	IL-21	CD4	59067	920	Gene	Gene	produce|xcomp|START_ENTITY T|ccomp|produce T|nsubj|CXCR5 CXCR5|compound|END_ENTITY	CD4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- T cells in chronic HCV_infection produce less IL-21 , yet are efficient at supporting B cell responses .
25343703	0	IL-21	102,107	CD4	37,40	IL-21	CD4	59067	920	Gene	Gene	Associated|nmod|START_ENTITY +|dobj|Associated +|nsubj|Frequencies Frequencies|nmod|END_ENTITY	Decreased Frequencies of Circulating CD4 + T Follicular Helper Cells Associated with Diminished Plasma IL-21 in Active Pulmonary_Tuberculosis .
25492803	0	IL-21	0,5	CD4	19,22	IL-21	CD4	60505(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|differentiation differentiation|compound|END_ENTITY	IL-21 induction of CD4 + T cell differentiation into Th17 cells contributes to bleomycin-induced fibrosis in mice .
25652388	0	IL-21	0,5	CD4	20,23	IL-21	CD4	59067	920	Gene	Gene	production|compound|START_ENTITY production|nmod|effector effector|compound|END_ENTITY	IL-21 production by CD4 -LRB- + -RRB- effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients .
25780036	0	IL-21	20,25	CD4	0,3	IL-21	CD4	59067	920	Gene	Gene	T|dobj|START_ENTITY T|nsubj|+ +|compound|END_ENTITY	CD4 + T Cell-Derived IL-21 and Deprivation of CD40 Signaling Favor the In Vivo Development of Granzyme_B-Expressing Regulatory B Cells in HIV Patients .
26170288	0	IL-21	37,42	CD4	55,58	IL-21	CD4	59067	920	Gene	Gene	roles|nmod|START_ENTITY function|nsubj|roles function|nmod|cells cells|compound|END_ENTITY	Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 + T cells .
26239551	0	IL-21	6,11	CD4	22,25	IL-21	CD4	59067	920	Gene	Gene	IFN-y|compound|START_ENTITY END_ENTITY|nsubj|IFN-y	Human IL-21 -LRB- + -RRB- IFN-y -LRB- + -RRB- CD4 -LRB- + -RRB- T cells in nasal_polyps are regulated by IL-12 .
26436852	0	IL-21	100,105	CD4	12,15	IL-21	CD4	59067	920	Gene	Gene	Secretion|compound|START_ENTITY Production|dep|Secretion T|xcomp|Production T|nsubj|CXCR5 CXCR5|compound|END_ENTITY	Circulating CD4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- T Cells Exacerbate B Cell Antibody Production in Crohn 's _ Disease Through IL-21 Secretion .
26818544	0	IL-21	50,55	CD4	0,3	IL-21	CD4	59067	920	Gene	Gene	cells|nmod|START_ENTITY activate|dobj|cells activate|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + CXCR5 + T cells activate CD27 + IgG + B cells via IL-21 in patients with hepatitis_C_virus_infection .
27067007	0	IL-21	64,69	CD4	73,76	IL-21	CD4	59067	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Dynamic Long-Range Chromatin Interaction Controls Expression of IL-21 in CD4 + T Cells .
15630141	0	IL-21	11,16	CD8	41,44	IL-21	CD8	59067	925	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|nmod|expansion expansion|compound|END_ENTITY	Synergy of IL-21 and IL-15 in regulating CD8 + T cell expansion and function .
16002671	0	IL-21	0,5	CD8	62,65	IL-21	CD8	59067	925	Gene	Gene	sustains|nsubj|START_ENTITY sustains|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	IL-21 sustains CD28 expression on IL-15-activated human naive CD8 + T cells .
16081794	0	IL-21	0,5	CD8	80,83	IL-21	CD8	59067	925	Gene	Gene	influences|nsubj|START_ENTITY influences|dobj|frequency frequency|nmod|response response|compound|END_ENTITY	IL-21 influences the frequency , phenotype , and affinity of the antigen-specific CD8 T cell response .
17548600	0	IL-21	0,5	CD8	40,43	IL-21	CD8	59067	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype .
17921346	0	IL-21	0,5	CD8	82,85	IL-21	CD8	59067	925	Gene	Gene	mediated|nsubj|START_ENTITY mediated|nmod|generation generation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8 + cytotoxic T lymphocytes .
19687290	0	IL-21	43,48	CD8	27,30	IL-21	CD8	59067	925	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	Induction of granulysin in CD8 + T cells by IL-21 and IL-15 is suppressed by human_immunodeficiency_virus-1 .
19797296	0	IL-21	0,5	CD8	86,89	IL-21	CD8	59067	925	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	IL-21 preferentially enhances IL-15-mediated homeostatic proliferation of human CD28 + CD8 memory T cells throughout the adult age span .
20844201	0	IL-21	0,5	CD8	28,31	IL-21	CD8	59067	925	Gene	Gene	deficiency|compound|START_ENTITY influences|nsubj|deficiency influences|dobj|quality quality|nummod|END_ENTITY	IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral_infection .
21064084	0	IL-21	87,92	CD8	71,74	IL-21	CD8	59067	925	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	Enhancement of proliferation and downregulation of TRAIL expression on CD8 + T cells by IL-21 .
21257966	0	IL-21	10,15	CD8	42,45	IL-21	CD8	59067	925	Gene	Gene	signaling|compound|START_ENTITY critical|nsubj|signaling critical|nmod|survival survival|compound|END_ENTITY	Intrinsic IL-21 signaling is critical for CD8 T cell survival and memory formation in response to vaccinia viral_infection .
21258423	0	IL-21	8,13	CD8	79,82	IL-21	CD8	59067	925	Gene	Gene	signal|compound|START_ENTITY Lack|nmod|signal attenuates|nsubj|Lack attenuates|nmod|absence absence|nmod|T-cells T-cells|compound|END_ENTITY	Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells .
22238455	0	IL-21	0,5	CD8	102,105	IL-21	CD8	59067	925	Gene	Gene	supplement|nsubj|START_ENTITY supplement|dobj|cells cells|compound|activation activation|nmod|manner manner|nmod|T T|compound|END_ENTITY	IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8 -LRB- + -RRB- T cells .
22430249	0	IL-21	19,24	CD8	36,39	IL-21	CD8	59067	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	IL-27 induction of IL-21 from human CD8 + T cells induces granzyme_B in an autocrine manner .
23479229	0	IL-21	0,5	CD8	15,18	IL-21	CD8	59067	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activity activity|compound|END_ENTITY	IL-21 promotes CD8 + CTL activity via the transcription factor T-bet .
26826252	0	IL-21	29,34	CD8	121,124	IL-21	CD8	59067	925	Gene	Gene	Subsets|amod|START_ENTITY Subsets|compound|END_ENTITY	A Context-Dependent Role for IL-21 in Modulating the Differentiation , Distribution , and Abundance of Effector and Memory CD8 T Cell Subsets .
18056361	0	IL-21	106,111	CXCR5	124,129	IL-21	CXCR5	59067	643	Gene	Gene	START_ENTITY|acl|produced produced|nmod|cells cells|compound|END_ENTITY	Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells : predominant role of IL-21 produced by CXCR5 + T follicular helper cells .
15178704	0	IL-21	20,25	IFN-alpha	0,9	IL-21	IFN-alpha	59067	3439	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-alpha regulates IL-21 and IL-21R expression in human NK and T cells .
12759422	0	IL-21	0,5	IFN-gamma	46,55	IL-21	IFN-gamma	59067	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells .
16951332	0	IL-21	0,5	IFN-gamma	15,24	IL-21	IFN-gamma	59067	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression .
22785229	0	IL-21	27,32	IL-15	0,5	IL-21	IL-15	59067	3600	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	IL-15 positively regulates IL-21 production in celiac disease mucosa .
22442347	0	IL-21	0,5	IL-2	22,26	IL-21	IL-2	60505(Tax:10090)	16183(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis .
22235133	0	IL-21	63,68	IL-21R	46,52	IL-21	IL-21R	59067	50615	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Crystal structure of interleukin-21_receptor -LRB- IL-21R -RRB- bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R .
24796415	0	IL-21	0,5	IL-22	14,19	IL-21	IL-22	60505(Tax:10090)	50929(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-21 induces IL-22 production in CD4 + T cells .
24313807	0	IL-21	50,55	IL-23R	35,41	IL-21	IL-23R	59067	149233	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|compound|END_ENTITY	Study of the relationships between IL-23R , IL-17 , IL-21 polymorphisms and serum level of IL-17 , IL-21 with acute graft rejection in iranian liver transplant recipients .
17898044	0	IL-21	0,5	IL-7	22,26	IL-21	IL-7	59067	3574	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells .
16551679	0	IL-21	0,5	SOCS	15,19	IL-21	SOCS	59067	1154	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells .
26170288	0	IL-21	37,42	STAT1	18,23	IL-21	STAT1	59067	6772	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 + T cells .
18296629	0	IL-21	0,5	STAT5	53,58	IL-21	STAT5	59067	6776	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	IL-21 is expressed in Hodgkin_lymphoma and activates STAT5 : evidence that activated STAT5 is required for Hodgkin_lymphomagenesis .
20042469	0	IL-21	97,102	TGF-beta	65,73	IL-21	TGF-beta	59067	7040	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	c-Maf activates the promoter and enhancer of the IL-21 gene , and TGF-beta inhibits c-Maf-induced IL-21 production in CD4 + T cells .
20639489	0	IL-21	18,23	c-Rel	63,68	IL-21	c-Rel	60505(Tax:10090)	19696(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the IL-21 gene by the NF-kB transcription factor c-Rel .
19687290	0	IL-21	43,48	granulysin	13,23	IL-21	granulysin	59067	10578	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Induction of granulysin in CD8 + T cells by IL-21 and IL-15 is suppressed by human_immunodeficiency_virus-1 .
18056403	0	IL-21	0,5	inhibitor_of_differentiation_2	14,44	IL-21	inhibitor of differentiation 2	60505(Tax:10090)	15902(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-21 induces inhibitor_of_differentiation_2 and leads to complete abrogation of anaphylaxis in mice .
17126530	0	IL-21	14,19	suppressor_of_cytokine_signaling-1	33,67	IL-21	suppressor of cytokine signaling-1	60505(Tax:10090)	12703(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of IL-21 signaling by suppressor_of_cytokine_signaling-1 -LRB- SOCS1 -RRB- in CD8 -LRB- + -RRB- T lymphocytes .
20574002	0	IL-21R	41,47	CD4	17,20	IL-21R	CD4	50615	920	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Altered effector CD4 + T cell function in IL-21R - / - CD4 + T cell-mediated graft-versus-host_disease .
22235133	0	IL-21R	46,52	IL-21	63,68	IL-21R	IL-21	50615	59067	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Crystal structure of interleukin-21_receptor -LRB- IL-21R -RRB- bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R .
27006279	0	IL-21R	85,91	MiR-30a	0,7	IL-21R	MiR-30a	60504(Tax:10090)	387225(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-30a inhibits Th17 differentiation and demyelination of EAE mice by targeting the IL-21R .
27000947	0	IL-22	18,23	AhR	0,3	IL-22	AhR	50929(Tax:10090)	11622(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	AhR modulates the IL-22 producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model .
21762495	0	IL-22	48,53	C5a	21,24	IL-22	C5a	50616	728	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular_degeneration .
24902798	0	IL-22	0,5	CCL20	15,20	IL-22	CCL20	50616	6364	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	IL-22 Enhances CCL20 Production in IL-1b-Stimulated Human Gingival Fibroblasts .
21400499	0	IL-22	0,5	CCR6	42,46	IL-22	CCR6	50929(Tax:10090)	12458(Tax:10090)	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|cells cells|compound|END_ENTITY	IL-22 is produced by yC-independent CD25 + CCR6 + innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality .
21400499	0	IL-22	0,5	CD25	36,40	IL-22	CD25	50929(Tax:10090)	16184(Tax:10090)	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|cells cells|compound|END_ENTITY	IL-22 is produced by yC-independent CD25 + CCR6 + innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality .
17088898	0	IL-22	29,34	CD4	58,61	IL-22	CD4	50616	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression and regulation of IL-22 in the IL-17-producing CD4 + T lymphocytes .
20231432	0	IL-22	23,28	CD4	42,45	IL-22	CD4	50929(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Notch signaling drives IL-22 secretion in CD4 + T cells by stimulating the aryl_hydrocarbon_receptor .
20683099	0	IL-22	28,33	CD4	54,57	IL-22	CD4	50616	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Evaluation of the effect of IL-22 on human cord blood CD4 + T cells .
23266494	0	IL-22	13,18	CD4	78,81	IL-22	CD4	50616	920	Gene	Gene	START_ENTITY|nmod|production production|nmod|T T|compound|END_ENTITY	Depletion of IL-22 during culture enhanced antigen-driven IFN-y production by CD4 -LRB- + -RRB- T cells from patients with active TB .
23518141	0	IL-22	66,71	CD4	30,33	IL-22	CD4	50616	920	Gene	Gene	phenotype|compound|START_ENTITY cells|nmod|phenotype cells|compound|END_ENTITY	Human mast cells drive memory CD4 + T cells toward an inflammatory IL-22 + phenotype .
23576801	0	IL-22	0,5	CD4	6,9	IL-22	CD4	50616	920	Gene	Gene	T-cells|compound|START_ENTITY T-cells|compound|END_ENTITY	IL-22 + CD4 + T-cells in patients with active systemic_lupus_erythematosus .
23589614	0	IL-22	64,69	CD4	30,33	IL-22	CD4	50616	920	Gene	Gene	produces|dobj|START_ENTITY population|dep|produces END_ENTITY|dep|population	Intestinal Lin - c-Kit + NKp46 - CD4 - population strongly produces IL-22 upon IL-1b stimulation .
23692034	0	IL-22	46,51	CD4	0,3	IL-22	CD4	50616	920	Gene	Gene	-17|amod|START_ENTITY producing|dobj|-17 cells|acl|producing cells|nsubj|cells T|ccomp|cells T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cells producing interleukin _ -LRB- IL -RRB- -17 , IL-22 and interferon-y are major effector T cells in nickel allergy .
23726764	0	IL-22	0,5	CD4	16,19	IL-22	CD4	50616	920	Gene	Gene	START_ENTITY|acl|secreting secreting|dobj|cells cells|nummod|END_ENTITY	IL-22 secreting CD4 + T cells in the patients with neuromyelitis_optica and multiple_sclerosis .
23727477	0	IL-22	35,40	CD4	50,53	IL-22	CD4	50616	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	IL-27 suppresses the production of IL-22 in human CD4 -LRB- + -RRB- T cells by inducing the expression of SOCS1 .
25148371	0	IL-22	71,76	CD4	113,116	IL-22	CD4	50616	920	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nmod|T-cells T-cells|compound|END_ENTITY	TL1A increases expression of CD25 , LFA-1 , CD134 and CD154 , and induces IL-22 and GM-CSF production from effector CD4 T-cells .
26401586	0	IL-22	35,40	Galectin-10	9,20	IL-22	Galectin-10	50616	1178	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	Elevated Galectin-10 Expression of IL-22 Producing T Cells in Atopic_Dermatitis Patients .
23266494	0	IL-22	13,18	IFN-y	58,63	IL-22	IFN-y	50616	3458	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Depletion of IL-22 during culture enhanced antigen-driven IFN-y production by CD4 -LRB- + -RRB- T cells from patients with active TB .
12407026	0	IL-22	0,5	IL-10	22,27	IL-22	IL-10	50616	3586	Gene	Gene	START_ENTITY|nmod|contrast contrast|nmod|END_ENTITY	IL-22 , in contrast to IL-10 , does not induce Ig production , due to absence of a functional IL-22 receptor on activated human B cells .
27031950	0	IL-22	76,81	IL-15	97,102	IL-22	IL-15	50616	3600	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Memory-Like Antigen-Specific Human NK Cells from TB Pleural Fluids Produced IL-22 in Response to IL-15 or Mycobacterium tuberculosis Antigens .
19330474	0	IL-22	0,5	IL-17	82,87	IL-22	IL-17	50616	3605	Gene	Gene	mediators|nsubj|START_ENTITY mediators|nmod|alterations alterations|nmod|psoriasis psoriasis|dep|are are|nsubj|END_ENTITY	IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not .
21688259	0	IL-22	83,88	IL-17	70,75	IL-22	IL-17	50616	3605	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets .
23328939	0	IL-22	45,50	IL-17	0,5	IL-22	IL-17	50929(Tax:10090)	16171(Tax:10090)	Gene	Gene	independent|advmod|START_ENTITY END_ENTITY|appos|independent	IL-17 / Th17 mediated synovial_inflammation is IL-22 independent .
25042982	0	IL-22	114,119	IL-17	108,113	IL-22	IL-17	50616	3605	Gene	Gene	environment|compound|START_ENTITY environment|compound|END_ENTITY	Neutrophils in antiretroviral therapy-controlled HIV demonstrate hyperactivation associated with a specific IL-17 / IL-22 environment .
20335534	0	IL-22	63,68	IL-17A	55,61	IL-22	IL-17A	50616	3605	Gene	Gene	IL-1|appos|START_ENTITY IL-1|compound|END_ENTITY	Skin_Inflammation Induced by the Synergistic Action of IL-17A , IL-22 , Oncostatin_M , IL-1 -LCB- alpha -RCB- , and TNF - -LCB- alpha -RCB- Recapitulates Some Features of Psoriasis .
20498020	0	IL-22	44,49	IL-17A	90,96	IL-22	IL-17A	50929(Tax:10090)	16171(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY Pathological|nmod|functions regulated|nsubjpass|Pathological regulated|nmod|END_ENTITY	Pathological versus protective functions of IL-22 in airway_inflammation are regulated by IL-17A .
21297073	0	IL-22	13,18	IL-17A	75,81	IL-22	IL-17A	50929(Tax:10090)	16171(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Dual Role of IL-22 in allergic_airway_inflammation and its cross-talk with IL-17A .
23505056	0	IL-22	0,5	IL-17A	16,22	IL-22	IL-17A	50929(Tax:10090)	16171(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|compound|END_ENTITY	IL-22 modulates IL-17A production and controls inflammation and tissue damage in experimental dengue_infection .
19830738	0	IL-22	18,23	IL-20	32,37	IL-22	IL-20	50616	50604	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	The Th17 cytokine IL-22 induces IL-20 production in keratinocytes : a novel immunological cascade with potential relevance in psoriasis .
24796415	0	IL-22	14,19	IL-21	0,5	IL-22	IL-21	50929(Tax:10090)	60505(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-21 induces IL-22 production in CD4 + T cells .
18509351	0	IL-22	23,28	IL-22	54,59	IL-22	IL-22	50616	50616	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK + anaplastic_large_cell_lymphoma .
18509351	0	IL-22	54,59	IL-22	23,28	IL-22	IL-22	50616	50616	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Aberrant expression of IL-22 receptor 1 and autocrine IL-22 stimulation contribute to tumorigenicity in ALK + anaplastic_large_cell_lymphoma .
22980486	0	IL-22	60,65	IL-22	91,96	IL-22	IL-22	417838(Tax:9031)	50616	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Molecular characterization and immunological roles of avian IL-22 and its soluble receptor IL-22 binding protein .
22980486	0	IL-22	91,96	IL-22	60,65	IL-22	IL-22	50616	417838(Tax:9031)	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Molecular characterization and immunological roles of avian IL-22 and its soluble receptor IL-22 binding protein .
24856143	0	IL-22	16,21	IL-22R1	22,29	IL-22	IL-22R1	50616	58985	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|compound|END_ENTITY	The role of the IL-22 / IL-22R1 axis in cancer .
21953641	0	IL-22	66,71	IL-23	52,57	IL-22	IL-23	50929(Tax:10090)	83430(Tax:10090)	Gene	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|development development|nmod|acute_hepatitis acute_hepatitis|nmod|END_ENTITY	Regulation of the development of acute_hepatitis by IL-23 through IL-22 and IL-17 production .
24238108	0	IL-22	14,19	IL-23	0,5	IL-22	IL-23	50929(Tax:10090)	83430(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-23 induces IL-22 and IL-17 production in response to Chlamydia_muridarum_genital_tract_infection , but the absence of these cytokines does not influence disease pathogenesis .
20142432	0	IL-22	12,17	NKp44	6,11	IL-22	NKp44	50616	9436	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human NKp44 + IL-22 + cells and LTi-like cells constitute a stable RORC + lineage distinct from conventional natural killer cells .
26853442	0	IL-22	15,20	P2X1	0,4	IL-22	P2X1	50616	5023	Gene	Gene	secretion|compound|START_ENTITY secretion|nummod|END_ENTITY	P2X1 regulated IL-22 secretion by innate lymphoid cells is required for efficient liver_regeneration .
23153456	0	IL-22	14,19	STAT1	59,64	IL-22	STAT1	50616	6772	Gene	Gene	START_ENTITY|advcl|activating activating|dobj|END_ENTITY	IFNa converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets .
19564350	0	IL-22	12,17	STAT3	0,5	IL-22	STAT3	50929(Tax:10090)	20848(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing .
15120651	0	IL-22	0,5	Th1	9,12	IL-22	Th1	50616	51497	Gene	Gene	START_ENTITY|appos|cytokine cytokine|amod|END_ENTITY	IL-22 , a Th1 cytokine that targets the pancreas and select other peripheral tissues .
25514475	0	IL-22	10,15	allergic_rhinitis	25,42	IL-22	allergic rhinitis	50616	260328	Gene	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Increased IL-22 level in allergic_rhinitis significantly correlates with clinical severity .
22808266	0	IL-22	30,35	keratin_17	49,59	IL-22	keratin 17	50929(Tax:10090)	16667(Tax:10090)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	The pro-inflammatory cytokine IL-22 up-regulates keratin_17 expression in keratinocytes via STAT3 and ERK1/2 .
24856143	0	IL-22R1	22,29	IL-22	16,21	IL-22R1	IL-22	58985	50616	Gene	Gene	axis|compound|START_ENTITY role|dep|axis role|nmod|END_ENTITY	The role of the IL-22 / IL-22R1 axis in cancer .
20194724	0	IL-23	26,31	APCs	46,50	IL-23	APCs	51561	325	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Triptolide inhibits IL-12 / IL-23 expression in APCs via CCAAT/enhancer-binding _ protein_alpha .
18606706	0	IL-23	0,5	CD4	67,70	IL-23	CD4	83430(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|compound|END_ENTITY	IL-23 induces receptor activator of NF-kappaB ligand expression on CD4 + T cells and promotes osteoclastogenesis in an autoimmune_arthritis model .
18403025	0	IL-23	10,15	CD46	83,87	IL-23	CD46	51561	4179	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple_sclerosis .
16339539	0	IL-23	35,40	Fas_ligand	0,10	IL-23	Fas ligand	83430(Tax:10090)	14103(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Fas_ligand induces cell-autonomous IL-23 production in dendritic cells , a mechanism for Fas_ligand-induced IL-17 production .
26220255	0	IL-23	71,76	GM-CSF	34,40	IL-23	GM-CSF	83430(Tax:10090)	12981(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|compound|END_ENTITY	IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23 .
19409487	0	IL-23	8,13	Gr-1	88,92	IL-23	Gr-1	83430(Tax:10090)	546644(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mobilization mobilization|nmod|END_ENTITY	Role of IL-23 in mobilization of immunoregulatory nitric_oxide - or superoxide-producing Gr-1 + cells from bone marrow .
26059829	0	IL-23	40,45	IFN-b	24,29	IL-23	IFN-b	83430(Tax:10090)	15977(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of IFN-b on IL-12 , IL-23 , and IL-10 expression in TLR-stimulated dendritic cells .
18497880	0	IL-23	87,92	IFN-gamma	93,102	IL-23	IFN-gamma	51561	3458	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn_disease via IL-23 / IFN-gamma axis .
20027291	0	IL-23	19,24	IFN-gamma	109,118	IL-23	IFN-gamma	51561	3458	Gene	Gene	induced|amod|START_ENTITY allow|nsubj|induced allow|nmod|induction induction|nmod|END_ENTITY	Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells .
20228197	0	IL-23	51,56	IFN-gamma	14,23	IL-23	IFN-gamma	83430(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Cutting edge : IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis .
21515794	0	IL-23	34,39	IFN-gamma	54,63	IL-23	IFN-gamma	51561	3458	Gene	Gene	regulation|nmod|START_ENTITY expression|nsubj|regulation expression|nmod|END_ENTITY	Posttranscriptional regulation of IL-23 expression by IFN-gamma through tristetraprolin .
18319062	0	IL-23	18,23	IFNgamma	0,8	IL-23	IFNgamma	51561	3458	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IFNgamma enhances IL-23 production during Francisella infection of human monocytes .
15682457	0	IL-23	0,5	IL-10	19,24	IL-23	IL-10	51561	3586	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human .
16751425	0	IL-23	0,5	IL-10	134,139	IL-23	IL-10	51561	3586	Gene	Gene	increased|nsubjpass|START_ENTITY increased|nmod|cells cells|nmod|production production|compound|END_ENTITY	IL-23 is increased in dendritic cells in multiple_sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production .
16751425	0	IL-23	83,88	IL-10	134,139	IL-23	IL-10	51561	3586	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	IL-23 is increased in dendritic cells in multiple_sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production .
18424480	0	IL-23	143,148	IL-10	10,15	IL-23	IL-10	51561	3586	Gene	Gene	expression|compound|START_ENTITY reducing|dobj|expression increases|advcl|reducing increases|nsubj|mRNA mRNA|compound|END_ENTITY	Increased IL-10 mRNA and IL-23 mRNA expression in multiple_sclerosis : interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression .
18424480	0	IL-23	143,148	IL-10	106,111	IL-23	IL-10	51561	3586	Gene	Gene	expression|compound|START_ENTITY reducing|dobj|expression increases|advcl|reducing increases|dobj|expression expression|compound|END_ENTITY	Increased IL-10 mRNA and IL-23 mRNA expression in multiple_sclerosis : interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression .
15682457	0	IL-23	0,5	IL-17	37,42	IL-23	IL-17	51561	3605	Gene	Gene	up-regulates|compound|START_ENTITY IL-10|nsubj|up-regulates IL-10|dobj|synthesis synthesis|compound|END_ENTITY	IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human .
16339539	0	IL-23	35,40	IL-17	107,112	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|appos|mechanism mechanism|nmod|production production|compound|END_ENTITY	Fas_ligand induces cell-autonomous IL-23 production in dendritic cells , a mechanism for Fas_ligand-induced IL-17 production .
16670765	0	IL-23	4,9	IL-17	10,15	IL-23	IL-17	51561	3605	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	The IL-23 / IL-17 axis in inflammation .
17335887	0	IL-23	0,5	IL-17	39,44	IL-23	IL-17	51561	3605	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|produce produce|dobj|END_ENTITY	IL-23 promotes CD4 + T cells to produce IL-17 in Vogt-Koyanagi-Harada_disease .
17548652	0	IL-23	114,119	IL-17	122,127	IL-23	IL-17	51561	3605	Gene	Gene	mediated|nmod|START_ENTITY mediated|parataxis|axis axis|nsubj|END_ENTITY	The proinflammatory effect of prostaglandin_E2 in experimental inflammatory_bowel_disease is mediated through the IL-23 -- > IL-17 axis .
17785829	0	IL-23	0,5	IL-17	94,99	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|xcomp|involving involving|dobj|END_ENTITY	IL-23 enhances host defense against vaccinia_virus infection via a mechanism partly involving IL-17 .
17888176	0	IL-23	0,5	IL-17	43,48	IL-23	IL-17	51561	3605	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|osteoclastogenesis osteoclastogenesis|nmod|END_ENTITY	IL-23 induces human osteoclastogenesis via IL-17 in vitro , and anti-IL-23 antibody attenuates collagen-induced arthritis in rats .
19247658	0	IL-23	14,19	IL-17	53,58	IL-23	IL-17	51561	3605	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|production production|compound|END_ENTITY	Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing_spondylitis .
19247658	0	IL-23	44,49	IL-17	53,58	IL-23	IL-17	51561	3605	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|production production|compound|END_ENTITY	Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing_spondylitis .
19380832	0	IL-23	79,84	IL-17	85,90	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Imiquimod-induced psoriasis-like skin_inflammation in mice is mediated via the IL-23 / IL-17 axis .
19542449	0	IL-23	0,5	IL-17	33,38	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|nmod|END_ENTITY	IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons .
19657089	0	IL-23	12,17	IL-17	18,23	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|compound|END_ENTITY	The role of IL-23 / IL-17 axis in lupus_nephritis .
20392505	0	IL-23	12,17	IL-17	18,23	IL-23	IL-17	51561	3605	Gene	Gene	START_ENTITY|dep|response response|amod|END_ENTITY	Unregulated IL-23 / IL-17 immune response in autoimmune_diseases .
20555351	0	IL-23	59,64	IL-17	65,70	IL-23	IL-17	51561	3605	Gene	Gene	START_ENTITY|parataxis|plaques plaques|nsubj|axis axis|compound|END_ENTITY	Effective narrow-band UVB radiation therapy suppresses the IL-23 / IL-17 axis in normalized psoriasis plaques .
20951792	0	IL-23	0,5	IL-17	71,76	IL-23	IL-17	51561	3605	Gene	Gene	modulated|nsubj|START_ENTITY modulated|ccomp|induce induce|dobj|EAE EAE|nmod|pathway pathway|amod|END_ENTITY	IL-23 modulated myelin-specific T cells induce EAE via an IFNy driven , IL-17 independent pathway .
22343219	0	IL-23	77,82	IL-17	83,88	IL-23	IL-17	51561	3605	Gene	Gene	activation|nmod|START_ENTITY activation|dep|axis axis|compound|END_ENTITY	Glycosphingolipids mediate pneumocystis cell wall b-glucan activation of the IL-23 / IL-17 axis in human dendritic cells .
23114581	0	IL-23	12,17	IL-17	18,23	IL-23	IL-17	51561	3605	Gene	Gene	Role|nmod|START_ENTITY Role|dep|axis axis|compound|END_ENTITY	Role of the IL-23 / IL-17 axis in Crohn 's _ disease .
23180821	0	IL-23	15,20	IL-17	21,26	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	TLR9-dependent IL-23 / IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity_pneumonitis .
23327801	0	IL-23	16,21	IL-17	22,27	IL-23	IL-17	51561	3605	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|compound|END_ENTITY	The role of the IL-23 / IL-17 axis in the pathogenesis of Graves ' _ disease .
23484173	0	IL-23	14,19	IL-17	20,25	IL-23	IL-17	51561	3605	Gene	Gene	Role|nmod|START_ENTITY Role|dep|axis axis|compound|END_ENTITY	Role of serum IL-23 / IL-17 axis in the relationship between periodontitis and coronary_heart_disease .
23825942	0	IL-23	103,108	IL-17	109,114	IL-23	IL-17	51561	3605	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Hepatitis_B_virus induces IL-23 production in antigen presenting cells and causes liver_damage via the IL-23 / IL-17 axis .
23843079	0	IL-23	0,5	IL-17	88,93	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	protection|compound|START_ENTITY dependent|nsubj|protection dependent|nmod|END_ENTITY	IL-23 protection against Plasmodium_berghei infection in mice is partially dependent on IL-17 from macrophages .
23994798	0	IL-23	4,9	IL-17	10,15	IL-23	IL-17	51561	3605	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	The IL-23 / IL-17 axis as a therapeutic target .
24424175	0	IL-23	4,9	IL-17	10,15	IL-23	IL-17	51561	3605	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	The IL-23 / IL-17 axis in psoriatic_arthritis .
24670452	0	IL-23	22,27	IL-17	28,33	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|axis axis|amod|inflammatory inflammatory|amod|END_ENTITY	-LSB- Effects of emodin on IL-23 / IL-17 inflammatory axis , Th17 cells and viral replication in mice with viral_myocarditis -RSB- .
24978886	0	IL-23	23,28	IL-17	29,34	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlates correlates|compound|END_ENTITY	Elevated expression of IL-23 / IL-17 pathway-related mediators correlates with exacerbation of pulmonary_inflammation during polymicrobial sepsis .
25046339	0	IL-23	41,46	IL-17	47,52	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	Cascade|compound|START_ENTITY Cascade|compound|END_ENTITY	IL-19 Is a Component of the Pathogenetic IL-23 / IL-17 Cascade in Psoriasis .
25114378	0	IL-23	51,56	IL-17	57,62	IL-23	IL-17	51561	3605	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|dep|axis axis|compound|END_ENTITY	Overexpression and selectively regulatory roles of IL-23 / IL-17 axis in the lesions of oral_lichen_planus .
25385822	0	IL-23	72,77	IL-17	21,26	IL-23	IL-17	51561	3605	Gene	Gene	Release|compound|START_ENTITY Cells|nmod|Release END_ENTITY|nmod|Cells	Chloroquine Promotes IL-17 Production by CD4 + T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells .
25595306	0	IL-23	19,24	IL-17	25,30	IL-23	IL-17	51561	3605	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|axis axis|compound|END_ENTITY	Involvement of the IL-23 / IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune_arthritis .
25803508	0	IL-23	13,18	IL-17	43,48	IL-23	IL-17	83430(Tax:10090)	16171(Tax:10090)	Gene	Gene	Superior|nsubj|START_ENTITY Superior|nmod|END_ENTITY	Neutralizing IL-23 Is Superior to Blocking IL-17 in Suppressing Intestinal Inflammation in a Spontaneous Murine Colitis Model .
26019446	0	IL-23	26,31	IL-17	20,25	IL-23	IL-17	51561	3605	Gene	Gene	axis|compound|START_ENTITY Contribution|dep|axis Contribution|nmod|END_ENTITY	Contribution of the IL-17 / IL-23 axis to the pathogenesis of inflammatory_bowel_disease .
26151690	0	IL-23	15,20	IL-17	21,26	IL-23	IL-17	51561	3605	Gene	Gene	insight|nmod|START_ENTITY insight|dep|axis axis|compound|END_ENTITY	New insight to IL-23 / IL-17 axis in Iranian_infected adult patients with gastritis : effects of genes polymorphisms on expression of cytokines .
26488809	0	IL-23	38,43	IL-17	13,18	IL-23	IL-17	27178	3605	Gene	Gene	Afraid|nmod|START_ENTITY Ai|acl|Afraid Ai|compound|END_ENTITY	Gut-Busters : IL-17 Ai n't Afraid of No IL-23 .
26653110	0	IL-23	14,19	IL-17	20,25	IL-23	IL-17	51561	3605	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting the IL-23 / IL-17 axis for the treatment of psoriasis and psoriatic_arthritis .
26774625	0	IL-23	88,93	IL-17	94,99	IL-23	IL-17	27178	3605	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interleukin-23 may contribute to the pathogenesis of lumbar_disc_herniation through the IL-23 / IL-17 pathway .
27067005	0	IL-23	14,19	IL-17	44,49	IL-23	IL-17	51561	3605	Gene	Gene	Induction|compound|START_ENTITY Induction|nmod|END_ENTITY	mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production .
21953641	0	IL-23	52,57	IL-22	66,71	IL-23	IL-22	83430(Tax:10090)	50929(Tax:10090)	Gene	Gene	acute_hepatitis|nmod|START_ENTITY development|nmod|acute_hepatitis Regulation|nmod|development Regulation|nmod|production production|amod|END_ENTITY	Regulation of the development of acute_hepatitis by IL-23 through IL-22 and IL-17 production .
24238108	0	IL-23	0,5	IL-22	14,19	IL-23	IL-22	83430(Tax:10090)	50929(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	IL-23 induces IL-22 and IL-17 production in response to Chlamydia_muridarum_genital_tract_infection , but the absence of these cytokines does not influence disease pathogenesis .
19247658	0	IL-23	14,19	IL-23	44,49	IL-23	IL-23	51561	51561	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing_spondylitis .
19247658	0	IL-23	44,49	IL-23	14,19	IL-23	IL-23	51561	51561	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing_spondylitis .
26477825	0	IL-23	108,113	IL-23R	114,120	IL-23	IL-23R	51561	149233	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23 / IL-23R / b-catenin pathway .
22621182	0	IL-23	35,40	IL-27	0,5	IL-23	IL-27	51561	246778	Gene	Gene	production|amod|START_ENTITY signal|nmod|production acts|nmod|signal acts|nsubj|END_ENTITY	IL-27 acts as a priming signal for IL-23 but not IL-12 production on human antigen-presenting_cells .
24796719	0	IL-23	40,45	IL-27	0,5	IL-23	IL-27	51561	246778	Gene	Gene	oppose|dobj|START_ENTITY oppose|nsubj|END_ENTITY	IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4 + T cells by inducing Blimp1 .
25031487	0	IL-23	0,5	IL-27	6,11	IL-23	IL-27	51561	246778	Gene	Gene	START_ENTITY|dep|Ratio Ratio|compound|END_ENTITY	IL-23 / IL-27 Ratio in Peripheral Blood of Patients with Breast_Cancer .
23467650	0	IL-23	12,17	THP-1	85,90	IL-23	THP-1	51561	2736	Gene	Gene	secretion|amod|START_ENTITY Kinetics|nmod|secretion antigens|nsubj|Kinetics antigens|nmod|cells cells|amod|monocytic monocytic|amod|END_ENTITY	Kinetics of IL-23 and IL-12 secretion in response to Toxoplasma_gondii antigens from THP-1 monocytic cells .
26477825	0	IL-23	108,113	THP-1	25,30	IL-23	THP-1	51561	2736	Gene	Gene	pathway|compound|START_ENTITY promote|nmod|pathway promote|nsubj|Macrophages Macrophages|acl|derived derived|nmod|END_ENTITY	Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23 / IL-23R / b-catenin pathway .
26528819	0	IL-23	98,103	THP-1	134,139	IL-23	THP-1	51561	2736	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma_gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells .
19834969	0	IL-23	102,107	TL1A	0,4	IL-23	TL1A	51561	9966	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn 's _ disease .
24910175	0	IL-23	76,81	Thymic_stromal_lymphopoietin	0,28	IL-23	Thymic stromal lymphopoietin	51561	85480	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Thymic_stromal_lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis .
24292977	0	IL-23	31,36	Tristetraprolin	0,15	IL-23	Tristetraprolin	83430(Tax:10090)	22695(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Tristetraprolin down-regulates IL-23 expression in colon_cancer cells .
26477825	0	IL-23	108,113	b-catenin	121,130	IL-23	b-catenin	51561	1499	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23 / IL-23R / b-catenin pathway .
21156751	0	IL-23	37,42	p19	32,35	IL-23	p19	83430(Tax:10090)	83430(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TLR2 deficiency by compromising p19 -LRB- IL-23 -RRB- expression limits Th 17 cell responses to Mycobacterium_tuberculosis .
26189370	0	IL-23	81,86	p19	87,90	IL-23	p19	83430(Tax:10090)	83430(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Prostaglandin_E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-kB pathways .
21515794	0	IL-23	34,39	tristetraprolin	72,87	IL-23	tristetraprolin	51561	7538	Gene	Gene	regulation|nmod|START_ENTITY expression|nsubj|regulation expression|nmod|END_ENTITY	Posttranscriptional regulation of IL-23 expression by IFN-gamma through tristetraprolin .
24313807	0	IL-23R	35,41	IL-17	43,48	IL-23R	IL-17	149233	3605	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|dep|END_ENTITY	Study of the relationships between IL-23R , IL-17 , IL-21 polymorphisms and serum level of IL-17 , IL-21 with acute graft rejection in iranian liver transplant recipients .
24313807	0	IL-23R	35,41	IL-21	50,55	IL-23R	IL-21	149233	59067	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|dep|END_ENTITY	Study of the relationships between IL-23R , IL-17 , IL-21 polymorphisms and serum level of IL-17 , IL-21 with acute graft rejection in iranian liver transplant recipients .
26477825	0	IL-23R	114,120	b-catenin	121,130	IL-23R	b-catenin	149233	1499	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23 / IL-23R / b-catenin pathway .
26222305	0	IL-23_Receptor	72,86	Interleukin-23_Receptor	0,23	IL-23 Receptor	Interleukin-23 Receptor	149233	149233	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Interleukin-23_Receptor Gene Polymorphism May Enhance Expression of the IL-23_Receptor , IL-17 , TNF-a and IL-6 in Behcet 's _ Disease .
26222305	0	IL-23_Receptor	72,86	Interleukin-23_Receptor	0,23	IL-23 Receptor	Interleukin-23 Receptor	149233	149233	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Interleukin-23_Receptor Gene Polymorphism May Enhance Expression of the IL-23_Receptor , IL-17 , TNF-a and IL-6 in Behcet 's _ Disease .
16982892	0	IL-23_p19	53,62	Rac1	0,4	IL-23 p19	Rac1	51561	5879	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rac1 negatively regulates lipopolysaccharide-induced IL-23_p19 expression in human macrophages and dendritic cells and NF-kappaB_p65 trans activation plays a novel role .
17182554	0	IL-23_p19	40,49	c-Rel	19,24	IL-23 p19	c-Rel	83430(Tax:10090)	19696(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY roles|nmod|expression roles|nmod|END_ENTITY	Essential roles of c-Rel in TLR-induced IL-23_p19 gene expression in dendritic cells .
24829419	0	IL-23p19	29,37	MMP-9	14,19	IL-23p19	MMP-9	83430(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Cutting Edge : MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response .
25441985	0	IL-24	21,26	CD133	35,40	IL-24	CD133	11009	8842	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Inhibitive effect of IL-24 gene on CD133 -LRB- + -RRB- laryngeal_cancer cells .
18199488	0	IL-24	0,5	IFN-gamma	16,25	IL-24	IFN-gamma	11009	3458	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	IL-24 modulates IFN-gamma expression in patients with tuberculosis .
20926331	0	IL-24	6,11	IL-10	36,41	IL-24	IL-10	11009	3586	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	mda-7 / IL-24 : a unique member of the IL-10 gene family promoting cancer-targeted_toxicity .
22027907	0	IL-24	54,59	IL-2	0,4	IL-24	IL-2	11009	3558	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells .
16044151	0	IL-24	103,108	IL-24	24,29	IL-24	IL-24	11009	11009	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Unique aspects of mda-7 / IL-24 antitumor bystander activity : establishing a role for secretion of MDA-7 / IL-24 protein by normal cells .
16044151	0	IL-24	24,29	IL-24	103,108	IL-24	IL-24	11009	11009	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Unique aspects of mda-7 / IL-24 antitumor bystander activity : establishing a role for secretion of MDA-7 / IL-24 protein by normal cells .
26417027	0	IL-24	16,21	Interleukin-24	0,14	IL-24	Interleukin-24	11009	11009	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Interleukin-24 -LRB- IL-24 -RRB- Expression and Biological Impact on HECV Endothelial Cells .
12907144	0	IL-24	23,28	MDA-7	17,22	IL-24	MDA-7	170819(Tax:10116)	170819(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	Tumor suppressor MDA-7 / IL-24 selectively inhibits vascular smooth_muscle_cell growth and migration .
15709189	0	IL-24	20,25	MDA-7	14,19	IL-24	MDA-7	11009	11009	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of MDA-7 / IL-24 and its clinical significance in resected non-small cell lung_cancer .
15880678	0	IL-24	6,11	MDA-7	0,5	IL-24	MDA-7	11009	11009	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	MDA-7 / IL-24 regulates proliferation , invasion and tumor cell radiosensitivity : a new cancer therapy ?
16710719	0	IL-24	28,33	MDA-7	22,27	IL-24	MDA-7	11009	11009	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Human interleukin_24 -LRB- MDA-7 / IL-24 -RRB- protein kills breast_cancer cells via the IL-20 receptor and is antagonized by IL-10 .
16912197	0	IL-24	47,52	MDA-7	41,46	IL-24	MDA-7	11009	11009	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	BiP/GRP78 is an intracellular target for MDA-7 / IL-24 induction of cancer-specific apoptosis .
16995981	0	IL-24	36,41	MDA-7	30,35	IL-24	MDA-7	11009	11009	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	-LSB- Adenovirus vector expressing MDA-7 / IL-24 selectively induces growth arrests and apoptosis in human hepatocellular_carcinoma cell lines independent of the state of p53 gene -RSB- .
17828282	0	IL-24	138,143	MDA-7	132,137	IL-24	MDA-7	11009	11009	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	MDA-7 / IL-24 , a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system , and inhibition of MDA-7 / IL-24 degradation enhances the antitumor activity .
18278464	0	IL-24	57,62	MDA-7	51,56	IL-24	MDA-7	11009	11009	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Replication-incompetent adenovirus vector-mediated MDA-7 / IL-24 selectively induces growth suppression and apoptosis of hepatoma cell Line SMMC-7721 .
22588557	0	IL-24	68,73	MDA-7	62,67	IL-24	MDA-7	11009	11009	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7 / IL-24 expression .
22629368	0	IL-24	6,11	MDA-7	0,5	IL-24	MDA-7	11009	11009	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|appos|induces	MDA-7 / IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosis .
26474456	0	IL-24	6,11	MDA-7	0,5	IL-24	MDA-7	93672(Tax:10090)	93672(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY END_ENTITY|dep|functions	MDA-7 / IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast_cancer .
12811827	0	IL-24	6,11	Mda-7	0,5	IL-24	Mda-7	11009	11009	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Mda-7 / IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways .
20383178	0	IL-24	55,60	Sp1	72,75	IL-24	Sp1	11009	6667	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	HDAC4 inhibits the transcriptional activation of mda-7 / IL-24 induced by Sp1 .
21732348	0	IL-24	6,11	clusterin	57,66	IL-24	clusterin	11009	1191	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	mda-7 / IL-24 differentially regulates soluble and nuclear clusterin in prostate_cancer .
16710719	0	IL-24	28,33	interleukin_24	6,20	IL-24	interleukin 24	11009	11009	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Human interleukin_24 -LRB- MDA-7 / IL-24 -RRB- protein kills breast_cancer cells via the IL-20 receptor and is antagonized by IL-10 .
15334067	0	IL-24	29,34	mda-7	23,28	IL-24	mda-7	11009	11009	Gene	Gene	cell|compound|START_ENTITY cell|amod|END_ENTITY	Mechanistic aspects of mda-7 / IL-24 cancer cell selectivity analysed via a bacterial fusion protein .
16225913	0	IL-24	50,55	mda-7	44,49	IL-24	mda-7	11009	11009	Gene	Gene	therapy|compound|START_ENTITY therapy|amod|END_ENTITY	Ovarian_cancer targeted adenoviral-mediated mda-7 / IL-24 gene therapy .
18413837	0	IL-24	101,106	mda-7	95,100	IL-24	mda-7	11009	11009	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7 / IL-24 gene .
20179672	0	IL-24	88,93	mda-7	82,87	IL-24	mda-7	11009	11009	Gene	Gene	therapy|compound|START_ENTITY therapy|amod|END_ENTITY	Inhibition of multiple protective signaling pathways and Ad .5 / 3 delivery enhances mda-7 / IL-24 therapy of malignant_glioma .
20948318	0	IL-24	16,21	mda-7	10,15	IL-24	mda-7	11009	11009	Gene	Gene	therapy|compound|START_ENTITY therapy|amod|END_ENTITY	Enhancing mda-7 / IL-24 therapy in renal_carcinoma_cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad .5 / 3 gene delivery .
21732348	0	IL-24	6,11	mda-7	0,5	IL-24	mda-7	11009	11009	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	mda-7 / IL-24 differentially regulates soluble and nuclear clusterin in prostate_cancer .
22820863	0	IL-24	49,54	mda-7	43,48	IL-24	mda-7	93672(Tax:10090)	93672(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Conditionally replicative adenovirus-based mda-7 / IL-24 expression enhances sensitivity of colon_cancer cells to 5-fluorouracil and doxorubicin .
20154671	0	IL-25	33,38	IL-9	14,18	IL-25	IL-9	64806	3578	Gene	Gene	signaling|compound|START_ENTITY Regulation|nmod|signaling Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-9 expression by IL-25 signaling .
25821217	0	IL-25	8,13	STAT5	40,45	IL-25	STAT5	64806	6776	Gene	Gene	Pathway|compound|START_ENTITY Pathway|nmod|END_ENTITY	A Novel IL-25 Signaling Pathway through STAT5 .
16393988	0	IL-25	51,56	TNF_receptor-associated_factor_6	15,47	IL-25	TNF receptor-associated factor 6	140806(Tax:10090)	22034(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Involvement of TNF_receptor-associated_factor_6 in IL-25 receptor signaling .
23240078	0	IL-27	0,5	BST-2	16,21	IL-27	BST-2	246778	684	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN .
12121660	0	IL-27	0,5	CD4	97,100	IL-27	CD4	246778	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	IL-27 , a heterodimeric cytokine composed of EBI3 and p28 protein , induces proliferation of naive CD4 + T cells .
19596985	0	IL-27	0,5	CD4	46,49	IL-27	CD4	246779(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|homeostasis homeostasis|nmod|pool pool|compound|END_ENTITY	IL-27 regulates homeostasis of the intestinal CD4 + effector T cell pool and limits intestinal_inflammation in a murine model of colitis .
19748991	0	IL-27	0,5	CD4	37,40	IL-27	CD4	246779(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|nummod|END_ENTITY	IL-27 regulates IL-10 and IL-17 from CD4 + cells in nonhealing Leishmania_major_infection .
21115047	0	IL-27	0,5	CD4	69,72	IL-27	CD4	246778	920	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|compound|END_ENTITY	IL-27 induces the differentiation of Tr1-like cells from human naive CD4 + T cells via the phosphorylation of STAT1 and STAT3 .
21453726	0	IL-27	0,5	CD4	37,40	IL-27	CD4	246778	920	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|nmod|cells cells|nummod|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
21669870	0	IL-27	45,50	CD4	89,92	IL-27	CD4	246778	920	Gene	Gene	interleukin_27|appos|START_ENTITY involved|nmod|interleukin_27 events|acl|involved events|dep|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Signaling events involved in interleukin_27 -LRB- IL-27 -RRB- - induced proliferation of human naive CD4 + T cells and B cells .
22116827	0	IL-27	50,55	CD4	7,10	IL-27	CD4	246778	920	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|cells cells|compound|END_ENTITY	Memory CD4 T cells induce selective expression of IL-27 in CD8 + dendritic cells and regulate homeostatic naive T cell proliferation .
23335749	0	IL-27	17,22	CD4	68,71	IL-27	CD4	246779(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes .
23536628	0	IL-27	0,5	CD4	35,38	IL-27	CD4	246779(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY regulates|nsubj|receptor regulates|dobj|responses responses|nummod|END_ENTITY	IL-27 receptor signaling regulates CD4 + T cell chemotactic responses during infection .
23727477	0	IL-27	0,5	CD4	50,53	IL-27	CD4	246778	920	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|nmod|cells cells|amod|IL-22 IL-22|nmod|T T|compound|END_ENTITY	IL-27 suppresses the production of IL-22 in human CD4 -LRB- + -RRB- T cells by inducing the expression of SOCS1 .
23993651	0	IL-27	15,20	CD4	84,87	IL-27	CD4	246778	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4 T cell responses and viral control during chronic_infection .
26222157	0	IL-27	0,5	CD4	116,119	IL-27	CD4	246779(Tax:10090)	12504(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Crucial|nsubj|Signaling Crucial|nmod|Survival Survival|nmod|Infected Infected|nmod|Trypanosomes Trypanosomes|nmod|Effects Effects|nmod|Cells Cells|compound|END_ENTITY	IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4 + T Cells and IFN-y .
26222157	0	IL-27	0,5	CD4	116,119	IL-27	CD4	246779(Tax:10090)	12504(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Crucial|nsubj|Signaling Crucial|nmod|Survival Survival|nmod|Infected Infected|nmod|Trypanosomes Trypanosomes|nmod|Effects Effects|nmod|Cells Cells|compound|END_ENTITY	IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4 + T Cells and IFN-y .
26657115	0	IL-27	0,5	IDO	32,35	IL-27	IDO	246778	3620	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IL-27 induces the expression of IDO and PD-L1 in human cancer cells .
17684041	0	IL-27	48,53	IFN-alpha	0,9	IL-27	IFN-alpha	246778	3439	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages .
23125412	0	IL-27	87,92	IFN-y	0,5	IL-27	IFN-y	246778	3458	Gene	Gene	modulation|nmod|START_ENTITY limits|nmod|modulation limits|nsubj|END_ENTITY	IFN-y limits Th9-mediated autoimmune_inflammation through dendritic cell modulation of IL-27 .
24741633	0	IL-27	0,5	IFN-y	76,81	IL-27	IFN-y	246778	3458	Gene	Gene	driven|amod|START_ENTITY upregulation|amod|driven inhibits|nsubj|upregulation inhibits|dobj|release release|amod|END_ENTITY	IL-27 driven upregulation of surface HLA-E expression on monocytes inhibits IFN-y release by autologous NK cells .
25194337	0	IL-27	0,5	IFN-y	15,20	IL-27	IFN-y	246778	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IL-27 inhibits IFN-y induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation of Mcl-1 in Mycobacterium_tuberculosis_H37Rv infected macrophages .
17985330	0	IL-27	114,119	IFN_regulatory_factor-1	79,102	IL-27	IFN regulatory factor-1	246778	3659	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	IFN-beta modulates the response to TLR stimulation in human DC : involvement of IFN_regulatory_factor-1 -LRB- IRF-1 -RRB- in IL-27 gene expression .
19748991	0	IL-27	0,5	IL-10	16,21	IL-27	IL-10	246779(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	IL-27 regulates IL-10 and IL-17 from CD4 + cells in nonhealing Leishmania_major_infection .
22205023	0	IL-27	0,5	IL-10	15,20	IL-27	IL-10	246779(Tax:10090)	16153(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	IL-27 promotes IL-10 production by effector Th1 CD4 + T cells : a critical mechanism for protection from severe immunopathology during malaria_infection .
22740240	0	IL-27	64,69	IL-12A	38,44	IL-27	IL-12A	246778	3592	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Associations between polymorphisms in IL-12A , IL-12B , IL-12Rb1 , IL-27 gene and serum levels of IL-12p40 , IL-27p28 with esophageal_cancer .
22621182	0	IL-27	0,5	IL-23	35,40	IL-27	IL-23	246778	51561	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|signal signal|nmod|production production|amod|END_ENTITY	IL-27 acts as a priming signal for IL-23 but not IL-12 production on human antigen-presenting_cells .
24796719	0	IL-27	0,5	IL-23	40,45	IL-27	IL-23	246778	51561	Gene	Gene	oppose|nsubj|START_ENTITY oppose|dobj|END_ENTITY	IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4 + T cells by inducing Blimp1 .
25031487	0	IL-27	6,11	IL-23	0,5	IL-27	IL-23	246778	51561	Gene	Gene	Ratio|compound|START_ENTITY END_ENTITY|dep|Ratio	IL-23 / IL-27 Ratio in Peripheral Blood of Patients with Breast_Cancer .
17353163	0	IL-27	0,5	IgG1	32,36	IL-27	IgG1	246778	16017(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	IL-27 induces the production of IgG1 by human B cells .
25718332	1	IL-27	30,35	Interleukin_27	14,28	IL-27	Interleukin 27	246778	246778	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Interleukin_27 -LRB- IL-27 -RRB- in the Colonic Mucosa of Patients with Inflammatory_Bowel_Disease .
26905929	0	IL-27	35,40	Interleukin_27	19,33	IL-27	Interleukin 27	246778	246778	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Protective role of Interleukin_27 -LRB- IL-27 -RRB- gene polymorphisms in patients with ulcerative_colitis .
20416175	0	IL-27	1,6	Mac-1	35,40	IL-27	Mac-1	246778	3689	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- IL-27 regulates the expression of Mac-1 , fMLP-R and IL-1beta in human neutrophils through p38 MAPK and PI3K signal pathways -RSB- .
21453726	0	IL-27	0,5	RANKL	17,22	IL-27	RANKL	246778	8600	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
21453726	0	IL-27	0,5	STAT3	66,71	IL-27	STAT3	246778	6774	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
14565860	0	IL-27	0,5	Stat1	31,36	IL-27	Stat1	246778	6772	Gene	Gene	signal|nsubj|START_ENTITY signal|nmod|END_ENTITY	IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells .
20468050	0	IL-27	0,5	TNF-alpha	28,37	IL-27	TNF-alpha	246778	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia .
24155891	0	IL-27	0,5	TRAIL	33,38	IL-27	TRAIL	246778	8743	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly -LRB- I : C -RRB- partly in a TRAIL-dependent manner .
18178832	0	IL-27	0,5	Th1	16,19	IL-27	Th1	246779(Tax:10090)	57314(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|response response|amod|END_ENTITY	IL-27 induces a Th1 immune response and susceptibility to experimental arthritis .
12734330	0	IL-27	22,27	WSX-1	28,33	IL-27	WSX-1	246778	9466	Gene	Gene	role|nmod|START_ENTITY edge|dep|role edge|parataxis|signaling signaling|nsubj|END_ENTITY	Cutting edge : role of IL-27 / WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment .
14764690	0	IL-27	72,77	WSX-1	0,5	IL-27	WSX-1	246778	9466	Gene	Gene	receptor|nmod|START_ENTITY constitute|dobj|receptor constitute|nsubj|END_ENTITY	WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 .
15494513	0	IL-27	4,9	WSX-1	20,25	IL-27	WSX-1	246779(Tax:10090)	50931(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The IL-27 receptor -LRB- WSX-1 -RRB- is an inhibitor of innate and adaptive elements of type 2 immunity .
15850576	0	IL-27	0,5	WSX-1	33,38	IL-27	WSX-1	246778	9466	Gene	Gene	subunits|compound|START_ENTITY subunits|appos|END_ENTITY	IL-27 subunits and its receptor -LRB- WSX-1 -RRB- mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental_autoimmune_encephalomyelitis .
16306766	0	IL-27	32,37	WSX-1	38,43	IL-27	WSX-1	246779(Tax:10090)	50931(Tax:10090)	Gene	Gene	property|nmod|START_ENTITY property|parataxis|required required|nsubjpass|signaling signaling|compound|END_ENTITY	T helper 1-inducing property of IL-27 / WSX-1 signaling is required for the induction of experimental colitis .
16920482	0	IL-27	48,53	WSX-1	75,80	IL-27	WSX-1	246778	9466	Gene	Gene	alpha|amod|START_ENTITY END_ENTITY|amod|alpha	Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1 .
19354069	0	IL-27	103,108	WSX-1	109,114	IL-27	WSX-1	246779(Tax:10090)	50931(Tax:10090)	Gene	Gene	lack|nmod|START_ENTITY responses|nmod|lack Amelioration|nmod|responses Amelioration|parataxis|signaling signaling|nsubj|END_ENTITY	Amelioration of experimental_allergic_rhinitis with suppression of topical immune responses by lack of IL-27 / WSX-1 signaling .
19570826	0	IL-27	14,19	c-Maf	53,58	IL-27	c-Maf	246779(Tax:10090)	17132(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Cutting edge : IL-27 induces the transcription factor c-Maf , cytokine IL-21 , and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells .
20676095	0	IL-27	122,127	c-Maf	45,50	IL-27	c-Maf	246778	4094	Gene	Gene	induced|nmod|START_ENTITY cells|acl|induced promote|xcomp|cells interacts|xcomp|promote interacts|nmod|END_ENTITY	The aryl_hydrocarbon_receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 .
22069308	0	IL-27	33,38	interleukin-27	17,31	IL-27	interleukin-27	246779(Tax:10090)	246779(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for interleukin-27 -LRB- IL-27 -RRB- as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription -LRB- STAT -RRB- protein signaling and induction of antibacterial and anti-inflammatory proteins .
15240707	0	IL-27	101,106	p28	86,89	IL-27	p28	365368(Tax:10116)	94189(Tax:10116)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27 .
15528388	0	IL-27	116,121	p28	101,104	IL-27	p28	246779(Tax:10090)	27061(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27 .
16493033	0	IL-27	0,5	suppressor_of_cytokine_signaling_3	81,115	IL-27	suppressor of cytokine signaling 3	246779(Tax:10090)	12702(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	IL-27 suppresses CD28-mediated -LSB- correction of medicated -RSB- IL-2 production through suppressor_of_cytokine_signaling_3 .
17227910	0	IL-27_p28	14,23	MyD88	63,68	IL-27 p28	MyD88	246779(Tax:10090)	17874(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of IL-27_p28 gene expression in macrophages through MyD88 - and interferon-gamma-mediated pathways .
24021664	0	IL-27p28	0,8	Th1	83,86	IL-27p28	Th1	246778	51497	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses .
16539846	0	IL-28	18,23	WISH	103,107	IL-28	WISH	282617	51517	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells .
16539846	0	IL-28	84,89	WISH	103,107	IL-28	WISH	282617	51517	Gene	Gene	IL-28|nmod|START_ENTITY IL-28|nmod|cells cells|compound|END_ENTITY	Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells .
20148705	0	IL-28A	14,20	CD4	41,44	IL-28A	CD4	282616	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	The effect of IL-28A on human cord blood CD4 + T cells .
24286242	0	IL-29	0,5	IL-6	43,47	IL-29	IL-6	282618	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid_arthritis patients .
24376757	0	IL-2R	57,62	CD25	81,85	IL-2R	CD25	3560	3559	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4 + CD25 -LRB- hi -RRB- T cells of type 1 diabetic and multiple_sclerosis patients .
8268974	0	IL-2R	22,27	CD25	29,33	IL-2R	CD25	3559	3559	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Relationship of IL-2 , IL-2R -LRB- CD25 + -RRB- , soluble IL-2R and IL-4 with disease activity in SLE patients .
1358556	0	IL-2R	16,21	CD4	47,50	IL-2R	CD4	3559	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Distribution of IL-2R and CD45Ro expression on CD4 + and CD8 + T-lymphocytes in the peripheral blood of patients with posterior uveitis .
1469522	0	IL-2R	16,21	CD4	63,66	IL-2R	CD4	3559	920	Gene	Gene	levels|compound|START_ENTITY related|nsubjpass|levels related|nmod|END_ENTITY	Increased serum IL-2R levels in coeliac_disease are related to CD4 but not CD8 antigens .
15678692	0	IL-2R	22,27	CD4	75,78	IL-2R	CD4	3559	920	Gene	Gene	system|compound|START_ENTITY alters|nsubj|system alters|dobj|proliferation proliferation|nmod|subset subset|compound|END_ENTITY	Dysregulation of IL-2 / IL-2R system alters proliferation of early activated CD4 + T cell subset in patients with end-stage_renal_failure .
19875613	0	IL-2R	11,16	CD4	87,90	IL-2R	CD4	3560	920	Gene	Gene	signaling|compound|START_ENTITY Defects|nmod|signaling contribute|nsubj|Defects contribute|nmod|maintenance maintenance|nmod|expression expression|nmod|CD25 CD25|compound|END_ENTITY	Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T-cells of type 1 diabetic subjects .
24376757	0	IL-2R	57,62	CD4	76,79	IL-2R	CD4	3560	920	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|CD25 CD25|compound|END_ENTITY	Multiple autoimmune-associated variants confer decreased IL-2R signaling in CD4 + CD25 -LRB- hi -RRB- T cells of type 1 diabetic and multiple_sclerosis patients .
8308269	0	IL-2R	31,36	CD4	19,22	IL-2R	CD4	3559	920	Gene	Gene	+|compound|START_ENTITY thymocyte|nsubj|+ thymocyte|advcl|Isolation Isolation|dep|END_ENTITY	Isolation of CD3 - , CD4 - , CD8 - , IL-2R + thymocyte precursors by panning .
22313865	0	IL-2R	34,39	Glycodelin-A	0,12	IL-2R	Glycodelin-A	3559	5047	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	Glycodelin-A interferes with IL-2 / IL-2R signalling to induce cell growth arrest , loss of effector functions and apoptosis in T-lymphocytes .
9177607	0	IL-2R	102,107	ICAM-1	57,63	IL-2R	ICAM-1	3559	3383	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Circulating levels of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and soluble interleukin_2_receptors -LRB- IL-2R -RRB- in patients with B cell chronic_lymphocytic_leukaemia .
2110211	0	IL-2R	53,58	IL-2	48,52	IL-2R	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	Intrathymic radioresistant stem cells follow an IL-2 / IL-2R pathway during thymic regeneration after sublethal irradiation .
3133411	0	IL-2R	39,44	IL-2	80,84	IL-2R	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the soluble murine IL-2R and estimation of its affinity for IL-2 .
8268974	0	IL-2R	22,27	IL-2	16,20	IL-2R	IL-2	3559	3558	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	Relationship of IL-2 , IL-2R -LRB- CD25 + -RRB- , soluble IL-2R and IL-4 with disease activity in SLE patients .
17559173	0	IL-2R	16,21	IL-2Rbeta	0,9	IL-2R	IL-2Rbeta	16184(Tax:10090)	16185(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	IL-2Rbeta links IL-2R signaling with Foxp3 expression .
1500859	0	IL-2R	146,151	p64	142,145	IL-2R	p64	3559	3561	Gene	Gene	chain|compound|START_ENTITY chain|amod|END_ENTITY	Characterization of the interleukin_2_receptors -LRB- IL-2R -RRB- expressed on human natural killer cells activated in vivo by IL-2 : association of the p64 IL-2R gamma chain with the IL-2R_beta chain in functional intermediate-affinity IL-2R .
20849903	0	IL-2RA	15,21	CD25	22,26	IL-2RA	CD25	3559	3559	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association of IL-2RA / CD25 with type 1 diabetes in the Belgian population .
19155502	0	IL-2RA	79,85	IL-2RA	8,14	IL-2RA	IL-2RA	3559	3559	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Soluble IL-2RA levels in multiple_sclerosis subjects and the effect of soluble IL-2RA on immune responses .
19155502	0	IL-2RA	8,14	IL-2RA	79,85	IL-2RA	IL-2RA	3559	3559	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Soluble IL-2RA levels in multiple_sclerosis subjects and the effect of soluble IL-2RA on immune responses .
1398765	0	IL-2R_alpha	20,31	CD25	14,18	IL-2R alpha	CD25	3559	3559	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Inhibition of CD25 -LRB- IL-2R_alpha -RRB- expression and T-cell proliferation by polyclonal anti-thymocyte globulins .
12391195	0	IL-2R_alpha	40,51	CD4	114,117	IL-2R alpha	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Homeostasis|nmod|cells shape|nsubj|Homeostasis shape|dobj|population population|acl:relcl|controls controls|dobj|numbers numbers|nummod|END_ENTITY	Homeostasis of peripheral CD4 + T cells : IL-2R_alpha and IL-2 shape a population of regulatory cells that controls CD4 + T cell numbers .
12391195	0	IL-2R_alpha	40,51	CD4	26,29	IL-2R alpha	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Homeostasis of peripheral CD4 + T cells : IL-2R_alpha and IL-2 shape a population of regulatory cells that controls CD4 + T cell numbers .
1674955	0	IL-2R_alpha	63,74	CD4	103,106	IL-2R alpha	CD4	3559	920	Gene	Gene	chain|amod|START_ENTITY chain|nmod|cells cells|nummod|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
9620592	0	IL-2R_alpha	38,49	CD4	11,14	IL-2R alpha	CD4	16184(Tax:10090)	12504(Tax:10090)	Gene	Gene	chain|compound|START_ENTITY expression|nmod|chain cells|dep|expression cells|compound|END_ENTITY	Regulatory CD4 T cells : expression of IL-2R_alpha chain , resistance to clonal deletion and IL-2 dependency .
25133396	0	IL-2Ra	67,73	IL-17A	27,33	IL-2Ra	IL-17A	16184(Tax:10090)	16171(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Differential modulation by IL-17A of Cholangitis_versus_Colitis in IL-2Ra deleted mice .
8612353	0	IL-2Ralpha	37,47	IL-15	0,5	IL-2Ralpha	IL-15	3559	3600	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	IL-15 induces the release of soluble IL-2Ralpha from human peripheral blood mononuclear cells .
11156399	0	IL-2Ralpha	154,164	IL-2	149,153	IL-2Ralpha	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	IL-2Ralpha-Directed monoclonal antibodies provide effective therapy in a murine model of adult_T-cell_leukemia by a mechanism other than blockade of IL-2 / IL-2Ralpha interaction .
12649439	0	IL-2Ralpha	60,70	IL-2	148,152	IL-2Ralpha	IL-2	3559	3558	Gene	Gene	component|compound|START_ENTITY complexes|nmod|component interleukin-2|nmod|complexes characterization|nmod|interleukin-2 characterization|acl:relcl|inhibit inhibit|dobj|END_ENTITY	NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component , and with low molecular weight compounds that inhibit the IL-2 / IL-Ralpha interaction .
12231477	0	IL-2Ralpha	43,53	interleukin-2	69,82	IL-2Ralpha	interleukin-2	3559	3558	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
12649439	0	IL-2Ralpha	60,70	interleukin-2	24,37	IL-2Ralpha	interleukin-2	3559	3558	Gene	Gene	component|compound|START_ENTITY complexes|nmod|component END_ENTITY|nmod|complexes	NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component , and with low molecular weight compounds that inhibit the IL-2 / IL-Ralpha interaction .
12231477	0	IL-2Ralpha	43,53	interleukin-2_receptor_alpha	13,41	IL-2Ralpha	interleukin-2 receptor alpha	3559	3559	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
17371467	0	IL-2Ralpha	49,59	interleukin-2_receptor_alpha	19,47	IL-2Ralpha	interleukin-2 receptor alpha	3559	3559	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Association of the interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- / CD25 gene region with Graves ' _ disease using a multilocus test and tag SNPs .
20585888	0	IL-2Rb	78,84	ZNF300	0,6	IL-2Rb	ZNF300	3560	91975	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	ZNF300 , a recently identified human transcription factor , activates the human IL-2Rb promoter through the overlapping ZNF300/EGR1 binding site .
11131153	0	IL-2Rbeta	32,41	IL-2	0,4	IL-2Rbeta	IL-2	3560	3558	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	IL-2 induces the association of IL-2Rbeta , lyn , and MAP kinase ERK-1 in human neutrophils .
17559173	0	IL-2Rbeta	0,9	IL-2R	16,21	IL-2Rbeta	IL-2R	16185(Tax:10090)	16184(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	IL-2Rbeta links IL-2R signaling with Foxp3 expression .
9815258	0	IL-2Rbeta	58,67	IL-4Ralpha	69,79	IL-2Rbeta	IL-4Ralpha	16185(Tax:10090)	16190(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	In vivo function of an interleukin_2_receptor_beta_chain -LRB- IL-2Rbeta -RRB- / IL-4Ralpha cytokine receptor chimera potentiates allergic_airway_disease .
11434934	0	IL-2Rbeta	42,51	PI3K	88,92	IL-2Rbeta	PI3K	3560	5293	Gene	Gene	chain|compound|START_ENTITY domain|nmod|chain Deletion|nmod|domain increases|nsubj|Deletion increases|dobj|activity activity|compound|END_ENTITY	Deletion of the acidic-rich domain of the IL-2Rbeta chain increases receptor-associated PI3K activity .
18490721	0	IL-2Rbeta	108,117	PI3K	68,72	IL-2Rbeta	PI3K	3560	5293	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Late expression of granulysin by microbicidal CD4 + T cells requires PI3K - and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients .
24648606	0	IL-2_Receptor	35,48	CD4	60,63	IL-2 Receptor	CD4	3560	920	Gene	Gene	b-chain|compound|START_ENTITY pattern|nmod|b-chain pattern|nmod|cells cells|compound|END_ENTITY	Abnormal expression pattern of the IL-2_Receptor b-chain on CD4 + T cells in ANCA-associated vasculitis .
15100267	0	IL-2_receptor	9,22	CD4	44,47	IL-2 receptor	CD4	3560	920	Gene	Gene	START_ENTITY|acl|signaling signaling|dobj|pattern pattern|nmod|CD25 CD25|compound|END_ENTITY	Distinct IL-2_receptor signaling pattern in CD4 + CD25 + regulatory T cells .
15922716	0	IL-2_receptor	72,85	CD4	96,99	IL-2 receptor	CD4	3560	920	Gene	Gene	CD25|appos|START_ENTITY induction|nmod|CD25 Effects|dep|induction Effects|nmod|cells cells|compound|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
1900055	0	IL-2_receptor	27,40	CD4	79,82	IL-2 receptor	CD4	3560	920	Gene	Gene	expression|nmod|START_ENTITY subunits|nsubj|expression subunits|nmod|+ +|compound|END_ENTITY	Preferential expression of IL-2_receptor subunits on memory populations within CD4 + and CD8 + T cells .
1969884	2	IL-2_receptor	94,107	CD4	67,70	IL-2 receptor	CD4	3560	920	Gene	Gene	expression|compound|START_ENTITY cells|dobj|expression cells|nsubj|Down-regulation Down-regulation|nmod|T T|compound|END_ENTITY	Down-regulation of CD4 + T cells high-affinity IL-2_receptor expression .
19788505	0	IL-2_receptor	16,29	CD4	86,89	IL-2 receptor	CD4	3560	920	Gene	Gene	Disengaging|dobj|START_ENTITY Disengaging|dep|enhances enhances|dobj|proliferation proliferation|nmod|END_ENTITY	Disengaging the IL-2_receptor with daclizumab enhances IL-7-mediated proliferation of CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
8596025	0	IL-2_receptor	65,78	CD4	89,92	IL-2 receptor	CD4	3560	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential regulation of bcl-2 and bcl-x by CD3 , CD28 , and the IL-2_receptor in cloned CD4 + helper T cells .
9138018	0	IL-2_receptor	18,31	CD4	63,66	IL-2 receptor	CD4	3560	920	Gene	Gene	subunit|compound|START_ENTITY subunit|nmod|T T|compound|END_ENTITY	Expression of the IL-2_receptor gamma subunit in resting human CD4 T lymphocytes : mRNA is constitutively transcribed and the protein stored as an intracellular component .
7819101	0	IL-2_receptor	44,57	IL-10	26,31	IL-2 receptor	IL-10	3560	3586	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Prognostic value of serum IL-10 and soluble IL-2_receptor levels in aggressive non-Hodgkin 's _ lymphoma .
1668858	0	IL-2_receptor	26,39	IL-2	58,62	IL-2 receptor	IL-2	3560	3558	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and release of IL-2_receptor and production of IL-2 by activated T lymphocyte subsets .
2469650	0	IL-2_receptor	67,80	IL-2	42,46	IL-2 receptor	IL-2	16184(Tax:10090)	16183(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY sites|nmod|complex sites|amod|binding binding|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2105168	0	IL-2_receptor	79,92	interleukin_2	50,63	IL-2 receptor	interleukin 2	3560	3558	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	1,25-Dihydroxyvitamin _ D3 modulates the effects of interleukin_2 independent of IL-2_receptor binding .
2469650	0	IL-2_receptor	67,80	p55	160,163	IL-2 receptor	p55	16184(Tax:10090)	21937(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY sites|nmod|complex formation|nmod|sites Studies|nmod|formation Studies|dep|importance importance|nmod|determinant determinant|nmod|subunit subunit|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2469650	0	IL-2_receptor	67,80	p55	81,84	IL-2 receptor	p55	16184(Tax:10090)	21937(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|nummod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
1580147	0	IL-2_receptor	14,27	p75	28,31	IL-2 receptor	p75	3560	3560	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of IL-2_receptor / p75 on lymphocytes from patients with rubella .
2469650	0	IL-2_receptor	67,80	p75	87,90	IL-2 receptor	p75	16184(Tax:10090)	21938(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
11807626	0	IL-2_receptor_alpha	19,38	CD2	123,126	IL-2 receptor alpha	CD2	3559	914	Gene	Gene	Down-regulation|nmod|START_ENTITY characterizes|nsubj|Down-regulation characterizes|dobj|cells cells|acl|rendered rendered|nmod|engagement engagement|nummod|END_ENTITY	Down-regulation of IL-2_receptor_alpha -LRB- CD25 -RRB- characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12 .
1356123	0	IL-2_receptor_alpha	10,29	CD2	97,100	IL-2 receptor alpha	CD2	3559	914	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Prolonged IL-2_receptor_alpha / CD25 expression after T cell activation via the adhesion molecules CD2 and CD28 .
23483882	0	IL-2_receptor_alpha	84,103	CD8	125,128	IL-2 receptor alpha	CD8	3559	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2_receptor_alpha in mature , activated CD8 T cells .
11478799	0	IL-2_receptor_alpha	56,75	IL-2	24,28	IL-2 receptor alpha	IL-2	3559	3558	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of IL-2 and IL-15 on expression of IL-2_receptor_alpha .
2279736	0	IL-2_receptor_alpha	83,102	IL-2	0,4	IL-2 receptor alpha	IL-2	3559	100302458(Tax:9986)	Gene	Gene	chain|compound|START_ENTITY expressing|dobj|chain receptors|acl|expressing receptors|compound|END_ENTITY	IL-2 receptors on rabbit T-cell lines and their transfectants expressing the human IL-2_receptor_alpha chain .
8896456	0	IL-2_receptor_alpha	38,57	IL-2	3,7	IL-2 receptor alpha	IL-2	3559	3558	Gene	Gene	promoter|compound|START_ENTITY element|nmod|promoter element|compound|END_ENTITY	An IL-2 response element in the human IL-2_receptor_alpha chain promoter is a composite element that binds Stat5 , Elf-1 , HMG-I -LRB- Y -RRB- and a GATA family protein .
9079703	0	IL-2_receptor_alpha	47,66	IL-2	15,19	IL-2 receptor alpha	IL-2	3559	3558	Gene	Gene	gene|compound|START_ENTITY induction|nmod|gene Interleukin-2|dep|induction Interleukin-2|appos|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- - mediated induction of the IL-2_receptor_alpha chain gene .
2083254	0	IL-2_receptor_alpha	14,33	Sp1	0,3	IL-2 receptor alpha	Sp1	3559	6667	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Sp1 represses IL-2_receptor_alpha chain gene expression .
12002675	0	IL-3	23,27	AC133	89,94	IL-3	AC133	3562	8842	Gene	Gene	FLT3L|compound|START_ENTITY influence|nsubj|FLT3L influence|nmod|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
1730686	0	IL-3	34,38	AIC2A	57,62	IL-3	AIC2A	16187(Tax:10090)	12984(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Structure of mouse interleukin_3 -LRB- IL-3 -RRB- binding protein -LRB- AIC2A -RRB- .
10460616	0	IL-3	113,117	CD34	42,46	IL-3	CD34	3562	947	Gene	Gene	influence|nmod|START_ENTITY adhesion|dep|influence adhesion|nmod|cells cells|nummod|END_ENTITY	alpha4beta1 integrin-mediated adhesion of CD34 + cells from patients with chronic_myeloid_leukaemia : influence of IL-3 .
10527461	0	IL-3	20,24	CD34	75,79	IL-3	CD34	3562	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Correlation between IL-3 receptor expression and growth potential of human CD34 + hematopoietic cells from different tissues .
10946261	0	IL-3	0,4	CD34	63,67	IL-3	CD34	3562	947	Gene	Gene	production|compound|START_ENTITY lymphoid|nsubj|production lymphoid|nmod|CD38 CD38|compound|END_ENTITY	IL-3 increases production of B lymphoid progenitors from human CD34 + CD38 - cells .
12002675	0	IL-3	23,27	CD34	96,100	IL-3	CD34	3562	947	Gene	Gene	FLT3L|compound|START_ENTITY influence|nsubj|FLT3L influence|nmod|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
12681965	0	IL-3	46,50	CD34	67,71	IL-3	CD34	3562	947	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|expansion expansion|nmod|cells cells|nummod|+ +|compound|END_ENTITY	IL-6 precludes the differentiation induced by IL-3 on expansion of CD34 + cells from cord blood .
15564141	0	IL-3	0,4	CD34	71,75	IL-3	CD34	3562	947	Gene	Gene	increases|compound|START_ENTITY ex|nsubj|increases ex|dobj|efficiency efficiency|nmod|cells cells|compound|END_ENTITY	IL-3 or IL-7 increases ex vivo gene transfer efficiency in ADA-SCID BM CD34 + cells while maintaining in vivo lymphoid potential .
23040055	0	IL-3	113,117	CD34	42,46	IL-3	CD34	3562	947	Gene	Gene	optimized|nmod|START_ENTITY optimized|nsubjpass|development development|nmod|macrophages macrophages|nmod|cells cells|compound|END_ENTITY	The development of macrophages from human CD34 + haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF .
2467703	0	IL-3	41,45	CD34	81,85	IL-3	CD34	3562	947	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|proliferation proliferation|nmod|END_ENTITY	Combined and sequential effects of human IL-3 and GM-CSF on the proliferation of CD34 + hematopoietic cells from cord blood .
2475184	0	IL-3	113,117	CD34	139,143	IL-3	CD34	3562	947	Gene	Gene	cultured|nmod|START_ENTITY progenitors|acl|cultured progenitors|dep|characterization characterization|nmod|END_ENTITY	Sequential loss of CD34 and class II MHC antigens on purified cord blood hematopoietic progenitors cultured with IL-3 : characterization of CD34 - , HLA-DR + cells .
2475184	0	IL-3	113,117	CD34	19,23	IL-3	CD34	3562	947	Gene	Gene	cultured|nmod|START_ENTITY progenitors|acl|cultured antigens|dobj|progenitors HLA-DR|parataxis|antigens HLA-DR|nsubj|loss loss|nmod|END_ENTITY	Sequential loss of CD34 and class II MHC antigens on purified cord blood hematopoietic progenitors cultured with IL-3 : characterization of CD34 - , HLA-DR + cells .
7515297	0	IL-3	41,45	CD34	57,61	IL-3	CD34	3562	947	Gene	Gene	c-kit_ligand|nmod|START_ENTITY expand|nsubj|c-kit_ligand expand|dobj|subsets subsets|nummod|+ +|compound|END_ENTITY	c-kit_ligand combined with GM-CSF and/or IL-3 can expand CD34 + hematopoietic progenitor subsets for several weeks in vitro .
7520393	0	IL-3	82,86	CD34	136,140	IL-3	CD34	3562	947	Gene	Gene	interleukin-3|appos|START_ENTITY status|nmod|interleukin-3 status|dep|IL-1 IL-1|acl|stimulated stimulated|dobj|cells cells|nummod|END_ENTITY	Transforming_growth_factor-beta regulates the cell cycle status of interleukin-3 -LRB- IL-3 -RRB- plus IL-1 , stem_cell_factor , or IL-6 stimulated CD34 + human hematopoietic progenitor cells through different cell kinetic mechanisms depending on the applied stimulus .
10477722	0	IL-3	150,154	GM-CSF	126,132	IL-3	GM-CSF	3562	1437	Gene	Gene	interleukin-3|dep|START_ENTITY sequence|amod|interleukin-3 sequence|appos|END_ENTITY	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors that is serine-phosphorylated by GM-CSF .
10477722	0	IL-3	150,154	GM-CSF	209,215	IL-3	GM-CSF	3562	1437	Gene	Gene	interleukin-3|dep|START_ENTITY sequence|amod|interleukin-3 Identification|nmod|sequence serine-phosphorylated|nsubj|Identification serine-phosphorylated|nmod|END_ENTITY	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors that is serine-phosphorylated by GM-CSF .
10490850	0	IL-3	72,76	GM-CSF	77,83	IL-3	GM-CSF	3562	1437	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
11399637	0	IL-3	92,96	GM-CSF	65,71	IL-3	GM-CSF	3562	1437	Gene	Gene	Granulocyte-Macrophage_Colony_Stimulating_Factor|appos|START_ENTITY Granulocyte-Macrophage_Colony_Stimulating_Factor|appos|END_ENTITY	Implication of Granulocyte-Macrophage_Colony_Stimulating_Factor -LRB- GM-CSF -RRB- and Interleukin-3 -LRB- IL-3 -RRB- in Children with Acute_Myeloid_Leukaemia -LRB- AML -RRB- ; Malignancy .
1358241	0	IL-3	160,164	GM-CSF	134,140	IL-3	GM-CSF	3562	1437	Gene	Gene	granulocyte-macrophage_colony_stimulating_factor|appos|START_ENTITY granulocyte-macrophage_colony_stimulating_factor|appos|END_ENTITY	Upregulation of HLA class II , but not intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- by granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- or interleukin-3 -LRB- IL-3 -RRB- in synergy with dexamethasone .
15481143	0	IL-3	0,4	GM-CSF	67,73	IL-3	GM-CSF	3562	1437	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	IL-3 in dendritic cell development and function : a comparison with GM-CSF and IL-4 .
15777160	0	IL-3	54,58	GM-CSF	59,65	IL-3	GM-CSF	3562	1437	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|parataxis|locus locus|nsubj|END_ENTITY	Mechanisms of transcriptional regulation of the human IL-3 / GM-CSF locus by inducible tissue-specific promoters and enhancers .
17273755	0	IL-3	0,4	GM-CSF	21,27	IL-3	GM-CSF	3562	1437	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells .
1825663	0	IL-3	0,4	GM-CSF	27,33	IL-3	GM-CSF	3562	1437	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|binding binding|advmod|END_ENTITY	IL-3 specifically inhibits GM-CSF binding to the higher affinity receptor .
2049340	0	IL-3	106,110	GM-CSF	138,144	IL-3	GM-CSF	3562	1437	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene coordinate|dobj|regulation coordinate|nmod|box box|nmod|gene gene|amod|END_ENTITY	Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene : coordinate regulation of the IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation .
2049340	0	IL-3	66,70	GM-CSF	138,144	IL-3	GM-CSF	3562	1437	Gene	Gene	gene|compound|START_ENTITY sequence|nmod|gene motif|nmod|sequence Definition|nmod|motif Definition|dep|coordinate coordinate|nmod|box box|nmod|gene gene|amod|END_ENTITY	Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene : coordinate regulation of the IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation .
21262803	0	IL-3	6,10	GM-CSF	11,17	IL-3	GM-CSF	16187(Tax:10090)	12981(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|support support|nsubj|mice mice|amod|END_ENTITY	Human IL-3 / GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung .
21831442	0	IL-3	55,59	GM-CSF	60,66	IL-3	GM-CSF	3562	1437	Gene	Gene	element|nmod|START_ENTITY END_ENTITY|dep|element	NF-kB and BRG1 bind a distal regulatory element in the IL-3 / GM-CSF locus .
2201826	0	IL-3	0,4	GM-CSF	29,35	IL-3	GM-CSF	3562	1437	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|the the|nmod|END_ENTITY	IL-3 inhibits the binding of GM-CSF to AML_blasts , but the two cytokines act synergistically in supporting blast proliferation .
23024272	0	IL-3	54,58	GM-CSF	59,65	IL-3	GM-CSF	3562	1437	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|controlled controlled|nsubjpass|locus locus|amod|END_ENTITY	The inducible tissue-specific expression of the human IL-3 / GM-CSF locus is controlled by a complex array of developmentally regulated enhancers .
2444835	0	IL-3	23,27	GM-CSF	29,35	IL-3	GM-CSF	3562	1437	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of recombinant IL-3 , GM-CSF , and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures .
2483920	0	IL-3	48,52	GM-CSF	0,6	IL-3	GM-CSF	16187(Tax:10090)	12981(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY preferential|nmod|expression preferential|nsubj|expression expression|amod|END_ENTITY	GM-CSF expression is preferential to multi-CSF -LRB- IL-3 -RRB- expression in murine T lymphocyte clones .
7516914	0	IL-3	106,110	GM-CSF	16,22	IL-3	GM-CSF	3562	1437	Gene	Gene	pretreatment|nmod|START_ENTITY circulating|nmod|pretreatment mobilization|acl|circulating induced|dobj|mobilization induced|nsubj|Potentiation Potentiation|nmod|END_ENTITY	Potentiation of GM-CSF or G-CSF induced mobilization of circulating progenitor cells by pretreatment with IL-3 and harvest by apheresis .
7534715	0	IL-3	49,53	GM-CSF	61,67	IL-3	GM-CSF	16187(Tax:10090)	12981(Tax:10090)	Gene	Gene	chronopharmacology|nmod|START_ENTITY END_ENTITY|nmod|chronopharmacology	In vitro chronopharmacology of recombinant mouse IL-3 , mouse GM-CSF , and human G-CSF on murine myeloid progenitor cells .
7545466	0	IL-3	128,132	GM-CSF	104,110	IL-3	GM-CSF	3562	1437	Gene	Gene	interleukin-3|dep|START_ENTITY role|amod|interleukin-3 role|appos|END_ENTITY	Evidence for a signaling role for the alpha chains of granulocyte-macrophage colony-stimulating factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors : divergent signaling pathways between GM-CSF/IL -3 and IL-5 .
7615047	0	IL-3	36,40	GM-CSF	49,55	IL-3	GM-CSF	3562	1437	Gene	Gene	IL-11|dep|START_ENTITY IL-11|dep|END_ENTITY	Influence of cytokines -LRB- IL-1_alpha , IL-3 , IL-11 , GM-CSF -RRB- on megakaryocyte-fibroblast interactions in normal human bone marrow .
7835337	0	IL-3	80,84	GM-CSF	85,91	IL-3	GM-CSF	3562	1437	Gene	Gene	Suppression|nmod|START_ENTITY Suppression|parataxis|receptors receptors|amod|END_ENTITY	Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3 / GM-CSF receptors .
7858491	0	IL-3	48,52	GM-CSF	40,46	IL-3	GM-CSF	3562	1437	Gene	Gene	configuration|appos|START_ENTITY configuration|nmod|END_ENTITY	Expression and genomic configuration of GM-CSF , IL-3 , M-CSF receptor -LRB- C-FMS -RRB- , early_growth_response_gene-1 _ -LRB- EGR-1 -RRB- and M-CSF genes in primary myelodysplastic_syndromes .
8788116	0	IL-3	37,41	GM-CSF	97,103	IL-3	GM-CSF	16187(Tax:10090)	12981(Tax:10090)	Gene	Gene	interleukin-3|appos|START_ENTITY interleukin-3|appos|END_ENTITY	Effect of combination interleukin-3 -LRB- IL-3 -RRB- and granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- on hematopoiesis administered to retrovirus-infected immunodeficient mice receiving dose-escalation zidovudine -LRB- AZT -RRB- .
8972491	0	IL-3	101,105	GM-CSF	78,84	IL-3	GM-CSF	16187(Tax:10090)	12981(Tax:10090)	Gene	Gene	interleukin_3|appos|START_ENTITY interleukin_3|appos|END_ENTITY	The beta_c component of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / interleukin_3 -LRB- IL-3 -RRB- / IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression .
9794243	0	IL-3	65,69	GM-CSF	75,81	IL-3	GM-CSF	3562	1437	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|parataxis|IL-5 IL-5|dep|family family|amod|END_ENTITY	Regulation of proliferation , differentiation and survival by the IL-3 / IL-5 / GM-CSF receptor family .
2104898	2	IL-3	91,95	IFN-gamma	177,186	IL-3	IFN-gamma	16187(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|masked masked|nmod|action action|nmod|END_ENTITY	Murine CTL clones produce IL-3 and GM-CSF , the activity of which is masked by the inhibitory action of secreted IFN-gamma .
2971726	2	IL-3	146,150	IFN-gamma	65,74	IL-3	IFN-gamma	16187(Tax:10090)	15978(Tax:10090)	Gene	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated proliferation|nmod|cells inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	IFN-gamma inhibits the proliferation of murine bone marrow cells stimulated with IL-3 , IL-4 , or granulocyte-macrophage colony-stimulating factor .
8807498	0	IL-3	30,34	IFN-gamma	0,9	IL-3	IFN-gamma	16187(Tax:10090)	15978(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	IFN-gamma in combination with IL-3 accelerates platelet recovery in mice with 5-fluorouracil-induced marrow_aplasia .
8647228	0	IL-3	89,93	IL-11	41,46	IL-3	IL-11	16187(Tax:10090)	16156(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY reverses|dobj|effect reverses|nsubj|IL-4 IL-4|nmod|combination combination|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- in combination with IL-11 or IL-6 reverses the inhibitory effect of IL-3 on early B lymphocyte development .
8943559	0	IL-3	22,26	IL-11	0,5	IL-3	IL-11	16187(Tax:10090)	16156(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IL-11 synergizes with IL-3 in promoting the recovery of the immune system after irradiation .
1334461	0	IL-3	59,63	IL-4	0,4	IL-3	IL-4	16187(Tax:10090)	16189(Tax:10090)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells .
1717495	0	IL-3	47,51	IL-4	53,57	IL-3	IL-4	24495(Tax:10116)	287287(Tax:10116)	Gene	Gene	supported|nmod|START_ENTITY formation|acl|supported ligand|nsubj|formation ligand|nsubj|END_ENTITY	Murine mast cell colony formation supported by IL-3 , IL-4 , and recombinant rat stem_cell_factor , ligand for c-kit .
19098920	0	IL-3	57,61	IL-4	101,105	IL-3	IL-4	3562	3565	Gene	Gene	receptor|compound|START_ENTITY component|nmod|receptor Fc_receptor_gamma-chain|appos|component required|nsubjpass|Fc_receptor_gamma-chain required|nmod|production production|compound|END_ENTITY	Fc_receptor_gamma-chain , a constitutive component of the IL-3 receptor , is required for IL-3-induced IL-4 production in basophils .
2145362	0	IL-3	0,4	IL-4	28,32	IL-3	IL-4	16187(Tax:10090)	16189(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|nmod|END_ENTITY	IL-3 promotes production of IL-4 by splenic non-B , non-T cells in response to Fc_receptor cross-linkage .
25824485	0	IL-3	0,4	IL-4	38,42	IL-3	IL-4	3562	3565	Gene	Gene	synergises|nsubj|START_ENTITY synergises|nmod|END_ENTITY	IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes .
2680112	0	IL-3	108,112	IL-4	64,68	IL-3	IL-4	3562	3565	Gene	Gene	growth|amod|START_ENTITY modulate|dobj|growth modulate|nsubj|regulation regulation|nmod|lines lines|dep|END_ENTITY	Growth regulation of multi-factor-dependent myeloid cell lines : IL-4 , TGF-beta and pertussis toxin modulate IL-3 - or GM-CSF-induced growth by controlling cell cycle length .
2902144	0	IL-3	60,64	IL-4	4,8	IL-3	IL-4	16187(Tax:10090)	16189(Tax:10090)	Gene	Gene	maps|nmod|START_ENTITY maps|nsubj|gene gene|compound|END_ENTITY	The IL-4 gene maps to chromosome 11 , near the gene encoding IL-3 .
7751024	0	IL-3	14,18	IL-4	0,4	IL-3	IL-4	3562	3565	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line .
7871561	0	IL-3	62,66	IL-4	68,72	IL-3	IL-4	3562	3565	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
8568251	0	IL-3	15,19	IL-4	46,50	IL-3	IL-4	16187(Tax:10090)	16189(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	T cell-derived IL-3 induces the production of IL-4 by non-B , non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma_mansoni-infected mice .
8647228	0	IL-3	89,93	IL-4	15,19	IL-3	IL-4	16187(Tax:10090)	16189(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY reverses|dobj|effect reverses|nsubj|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- in combination with IL-11 or IL-6 reverses the inhibitory effect of IL-3 on early B lymphocyte development .
8818544	0	IL-3	0,4	IL-4	25,29	IL-3	IL-4	3562	3565	Gene	Gene	induces|dep|START_ENTITY induces|nmod|END_ENTITY	IL-3 in combination with IL-4 , induces the expression of functional CD1 molecules on monocytes .
9433149	0	IL-3	105,109	IL-4	111,115	IL-3	IL-4	3562	3565	Gene	Gene	therapy|appos|START_ENTITY END_ENTITY|nsubj|therapy	Recombinant human granulocyte-macrophage_colony-stimulating_factor therapy and endogenous plasma GM-CSF , _ IL-3 , IL-4 concentrations in pediatric patients with solid_tumors .
9794243	0	IL-3	65,69	IL-5	70,74	IL-3	IL-5	3562	3567	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|parataxis|END_ENTITY	Regulation of proliferation , differentiation and survival by the IL-3 / IL-5 / GM-CSF receptor family .
10456670	0	IL-3	86,90	IL-6	81,85	IL-3	IL-6	3562	3569	Gene	Gene	/|amod|START_ENTITY /|compound|END_ENTITY	Megakaryocyte induced fibroblast proliferation is enhanced by costimulation with IL-6 / IL-3 and dependent on secretory and adhesion events .
12513731	0	IL-3	153,157	IL-6	158,162	IL-3	IL-6	16187(Tax:10090)	16193(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Accelerating hematopoietic recovery in allogeneic bone marrow transplantation mice by co-infusion of marrow stromal cells transduced with dual genes of IL-3 / IL-6 -RSB- .
12681965	0	IL-3	46,50	IL-6	0,4	IL-3	IL-6	3562	3569	Gene	Gene	induced|nmod|START_ENTITY differentiation|acl|induced precludes|dobj|differentiation precludes|nsubj|END_ENTITY	IL-6 precludes the differentiation induced by IL-3 on expansion of CD34 + cells from cord blood .
2064960	0	IL-3	150,154	IL-6	96,100	IL-3	IL-6	3562	3569	Gene	Gene	dependent|nmod|START_ENTITY line|xcomp|dependent line|xcomp|dependent dependent|nmod|growth growth|nmod|END_ENTITY	Establishment and characterization of a plasma_cell_leukaemia cell line dependent for growth on IL-6 and a bi-phenotypic subclone dependent upon both IL-3 and IL-6 .
7536685	0	IL-3	45,49	IL-6	51,55	IL-3	IL-6	16187(Tax:10090)	16193(Tax:10090)	Gene	Gene	expanded|nmod|START_ENTITY expanded|ccomp|acquire acquire|nsubj|END_ENTITY	Murine marrow cells expanded in culture with IL-3 , IL-6 , IL-11 , and SCF acquire an engraftment defect in normal hosts .
7871561	0	IL-3	62,66	IL-6	74,78	IL-3	IL-6	3562	3569	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
8616012	0	IL-3	11,15	IL-6	79,83	IL-3	IL-6	3562	3569	Gene	Gene	Effects|nmod|START_ENTITY involved|nsubj|Effects involved|nmod|regulation regulation|nmod|mRNA mRNA|compound|END_ENTITY	Effects of IL-3 and LPS on transcription factors involved in the regulation of IL-6 mRNA .
7871561	0	IL-3	62,66	IL-8	80,84	IL-3	IL-8	3562	3576	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
7691943	0	IL-3	37,41	IL-9	13,17	IL-3	IL-9	16187(Tax:10090)	16198(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases .
25069739	0	IL-3	20,24	RANKL	45,50	IL-3	RANKL	3562	8600	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	In human basophils , IL-3 selectively induces RANKL expression that is modulated by IgER-dependent and IgER-independent stimuli .
7507191	0	IL-3	34,38	SCF	16,19	IL-3	SCF	16187(Tax:10090)	17311(Tax:10090)	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|nmod|END_ENTITY	Synergy between SCF or M-CSF with IL-3 or GM-CSF in FDC-P1 cells : a sensitive assay of transforming mutations of c-fms .
16199887	0	IL-3	43,47	SOCS3	74,79	IL-3	SOCS3	16187(Tax:10090)	12702(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|degradation degradation|compound|END_ENTITY	SOCS2 can enhance interleukin-2 -LRB- IL-2 -RRB- and IL-3 signaling by accelerating SOCS3 degradation .
22102340	0	IL-3	26,30	STAT5	0,5	IL-3	STAT5	3562	6776	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	STAT5 in human basophils : IL-3 is required for its Fc __ RI-mediated phosphorylation .
23261831	0	IL-3	22,26	Trib3	0,5	IL-3	Trib3	16187(Tax:10090)	228775(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Trib3 is regulated by IL-3 and affects bone marrow-derived mast cell survival and function .
9596995	0	IL-3	77,81	bcl-2	91,96	IL-3	bcl-2	3562	596	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	A phosphatidylcholine phospholipase C inhibitor , D609 , blocks interleukin-3 -LRB- IL-3 -RRB- - induced bcl-2 expression but not c-myc expression in human IL-3-dependent cells .
10453008	0	IL-3	84,88	beta_c	152,158	IL-3	beta c	3562	1439	Gene	Gene	promoter|nmod|START_ENTITY activity|nmod|promoter essential|nmod|activity essential|iobj|receptor receptor|dep|gene gene|amod|END_ENTITY	A composite C/EBP binding site is essential for the activity of the promoter of the IL-3 / IL-5 / granulocyte-macrophage colony-stimulating factor receptor beta_c gene .
7697542	0	IL-3	23,27	beta_c	40,46	IL-3	beta c	16187(Tax:10090)	12983(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Mice deficient for the IL-3 / GM-CSF/IL -5 beta_c receptor exhibit lung pathology and impaired immune response , while beta IL3 receptor-deficient mice are normal .
8639879	0	IL-3	87,91	beta_c	31,37	IL-3	beta c	16187(Tax:10090)	12983(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY truncations|appos|subunit truncations|nmod|END_ENTITY	Extracellular truncations of h beta_c , the common signaling subunit for interleukin-3 -LRB- IL-3 -RRB- , granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , and IL-5 , lead to ligand-independent activation .
8972491	0	IL-3	101,105	beta_c	4,10	IL-3	beta c	16187(Tax:10090)	12983(Tax:10090)	Gene	Gene	interleukin_3|appos|START_ENTITY component|nmod|interleukin_3 component|amod|END_ENTITY	The beta_c component of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / interleukin_3 -LRB- IL-3 -RRB- / IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression .
1737930	0	IL-3	6,10	c-jun	24,29	IL-3	c-jun	3562	3725	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Human IL-3 induction of c-jun in normal monocytes is independent of tyrosine kinase and involves protein kinase C .
10331436	0	IL-3	19,23	interleukin-3	4,17	IL-3	interleukin-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CNS interleukin-3 -LRB- IL-3 -RRB- expression and neurological_syndrome in antisense-IL-3 transgenic_mice .
10477686	0	IL-3	70,74	interleukin-3	55,68	IL-3	interleukin-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Heterodimerization of the alpha and beta chains of the interleukin-3 -LRB- IL-3 -RRB- receptor is necessary and sufficient for IL-3-induced mitogenesis .
3501044	0	IL-3	76,80	interleukin-3	61,74	IL-3	interleukin-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Transfection of a factor-dependent cell line with the murine interleukin-3 -LRB- IL-3 -RRB- cDNA results in autonomous growth and tumorigenesis .
7889941	0	IL-3	24,28	interleukin-3	9,22	IL-3	interleukin-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Impaired interleukin-3 -LRB- IL-3 -RRB- response of the A/J mouse is caused by a branch point deletion in the IL-3_receptor alpha subunit gene .
8167335	0	IL-3	33,37	interleukin-3	18,31	IL-3	interleukin-3	3562	3562	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Regulation of the interleukin-3 -LRB- IL-3 -RRB- receptor by IL-3 in the fetal liver-derived FL5 .12 cell line .
8246974	0	IL-3	66,70	interleukin-3	51,64	IL-3	interleukin-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	chain|appos|START_ENTITY chain|amod|END_ENTITY	Hematopoietic_cell_phosphatase associates with the interleukin-3 -LRB- IL-3 -RRB- receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis .
2158509	1	IL-3	48,52	macrophage-activating_factor	68,96	IL-3	macrophage-activating factor	16187(Tax:10090)	17132(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	I. IL-3 functions as a macrophage-activating_factor with unique properties , inducing Ia and lymphocyte_function-associated_antigen-1 but not cytotoxicity .
2653457	0	IL-3	91,95	multi-CSF	80,89	IL-3	multi-CSF	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nonneoplastic hematopoietic myeloproliferative_syndrome induced by dysregulated multi-CSF -LRB- IL-3 -RRB- expression .
14688333	0	IL-3	126,130	stem_cell_factor	108,124	IL-3	stem cell factor	3562	4254	Gene	Gene	IL-4|dep|START_ENTITY IL-4|compound|END_ENTITY	Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem_cell_factor , IL-3 , IL-4 , and nerve growth factor .
25595785	0	IL-31	38,43	CD4	63,66	IL-31	CD4	76399(Tax:10090)	12504(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4 + T Cells in Health and Disease .
20956341	0	IL-31	0,5	IL-31RA	16,23	IL-31	IL-31RA	76399(Tax:10090)	218624(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	IL-31 receptor -LRB- IL-31RA -RRB- knockout mice exhibit elevated responsiveness to oncostatin_M .
25381841	0	IL-31	27,32	IL-31RA	63,70	IL-31	IL-31RA	76399(Tax:10090)	218624(Tax:10090)	Gene	Gene	administration|nmod|START_ENTITY upregulates|nsubj|administration upregulates|dobj|IL-31_receptor_A IL-31_receptor_A|appos|END_ENTITY	Repeated administration of IL-31 upregulates IL-31_receptor_A -LRB- IL-31RA -RRB- in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice .
25847241	0	IL-31	22,27	IL-31RA	28,35	IL-31	IL-31RA	76399(Tax:10090)	218624(Tax:10090)	Gene	Gene	START_ENTITY|dep|Interactions Interactions|compound|END_ENTITY	Th2 Cytokines Augment IL-31 / IL-31RA Interactions via STAT6-dependent IL-31RA Expression .
25847241	0	IL-31	22,27	IL-31RA	69,76	IL-31	IL-31RA	76399(Tax:10090)	218624(Tax:10090)	Gene	Gene	START_ENTITY|dep|Interactions Interactions|nmod|Expression Expression|compound|END_ENTITY	Th2 Cytokines Augment IL-31 / IL-31RA Interactions via STAT6-dependent IL-31RA Expression .
23794184	0	IL-31	6,11	IL-33	0,5	IL-31	IL-33	386653	90865	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|appos|axis	IL-33 / IL-31 axis : a new pathological mechanisms for EGFR tyrosine kinase inhibitors-associated skin_toxicity .
17030248	0	IL-31	30,35	IL-4	51,55	IL-31	IL-4	386653	3565	Gene	Gene	levels|nmod|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic_contact_dermatitis .
23694808	0	IL-31	6,11	IL-4	26,30	IL-31	IL-4	386653	3565	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation .
22486751	0	IL-31	87,92	LL-37	16,21	IL-31	LL-37	386653	820	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Decreased serum LL-37 and vitamin_D3 levels in atopic_dermatitis : relationship between IL-31 and oncostatin_M .
25595785	0	IL-31	38,43	NFAT1	0,5	IL-31	NFAT1	76399(Tax:10090)	18019(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4 + T Cells in Health and Disease .
20956341	0	IL-31RA	16,23	IL-31	0,5	IL-31RA	IL-31	218624(Tax:10090)	76399(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	IL-31 receptor -LRB- IL-31RA -RRB- knockout mice exhibit elevated responsiveness to oncostatin_M .
25381841	0	IL-31RA	63,70	IL-31	27,32	IL-31RA	IL-31	218624(Tax:10090)	76399(Tax:10090)	Gene	Gene	IL-31_receptor_A|appos|START_ENTITY upregulates|dobj|IL-31_receptor_A upregulates|nsubj|administration administration|nmod|END_ENTITY	Repeated administration of IL-31 upregulates IL-31_receptor_A -LRB- IL-31RA -RRB- in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice .
25847241	0	IL-31RA	28,35	IL-31	22,27	IL-31RA	IL-31	218624(Tax:10090)	76399(Tax:10090)	Gene	Gene	Interactions|compound|START_ENTITY END_ENTITY|dep|Interactions	Th2 Cytokines Augment IL-31 / IL-31RA Interactions via STAT6-dependent IL-31RA Expression .
25847241	0	IL-31RA	69,76	IL-31	22,27	IL-31RA	IL-31	218624(Tax:10090)	76399(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Interactions|nmod|Expression END_ENTITY|dep|Interactions	Th2 Cytokines Augment IL-31 / IL-31RA Interactions via STAT6-dependent IL-31RA Expression .
25280942	0	IL-32	0,5	CCL5	22,26	IL-32	CCL5	9235	6352	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	IL-32 downregulates CCL5 expression through its interaction with PKC and STAT3 .
24996056	0	IL-32	0,5	IL-1b	29,34	IL-32	IL-32	9235	9235	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	IL-32 negatively regulates IL-1b production through its interaction with PKC and the inhibition of PU .1 phosphorylation .
24748497	0	IL-32	38,43	M-CSF	0,5	IL-32	M-CSF	9235	1435	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	M-CSF inhibits anti-HIV-1 activity of IL-32 , but they enhance M2-like phenotypes of macrophages .
19291698	0	IL-32	32,37	iNOS	52,56	IL-32	iNOS	9235	51477	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus_infection .
24396867	0	IL-32b	32,38	Interleukin-32	0,14	IL-32b	Interleukin-32	9235	9235	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Interleukin-32 interacts with IL-32b and inhibits IL-32b-mediated IL-10 production .
24512848	0	IL-32b	32,38	Interleukin-32	0,14	IL-32b	Interleukin-32	9235	9235	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Interleukin-32 interacts with IL-32b and inhibits IL-32b-mediated IL-10 production .
26666474	0	IL-33	0,5	ICAM-1	15,21	IL-33	ICAM-1	77125(Tax:10090)	15894(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	IL-33 promotes ICAM-1 expression via NF-kB in murine mast cells .
22673732	0	IL-33	14,19	IFN-y	34,39	IL-33	IFN-y	90865	3458	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of IL-33 expression by IFN-y and tumor_necrosis_factor-a in normal human epidermal keratinocytes .
24619410	0	IL-33	24,29	IFN-y	0,5	IL-33	IFN-y	90865	3458	Gene	Gene	level|compound|START_ENTITY controls|dobj|level controls|nsubj|END_ENTITY	IFN-y directly controls IL-33 protein level through a STAT1 - and LMP2-dependent mechanism .
26249267	0	IL-33	0,5	IFN-y	22,27	IL-33	IFN-y	90865	3458	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|amod|END_ENTITY	IL-33 promotes innate IFN-y production and modulates dendritic cell response in LCMV-induced hepatitis in mice .
26249267	0	IL-33	0,5	IFN-y	22,27	IL-33	IFN-y	90865	3458	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|amod|END_ENTITY	IL-33 promotes innate IFN-y production and modulates dendritic cell response in LCMV-induced hepatitis in mice .
17881510	0	IL-33	0,5	IL-13	14,19	IL-33	IL-13	77125(Tax:10090)	16163(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals .
23248269	0	IL-33	0,5	IL-13	22,27	IL-33	IL-13	90865	3596	Gene	Gene	drives|nsubj|START_ENTITY drives|dobj|production production|compound|END_ENTITY	IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms .
23521712	0	IL-33	7,12	IL-13	111,116	IL-33	IL-13	90865	3596	Gene	Gene	response|compound|START_ENTITY associated|nsubjpass|response associated|nmod|up-regulation up-regulation|nmod|END_ENTITY	A late IL-33 response after exposure to Schistosoma_haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils .
23683462	0	IL-33	72,77	IL-13	27,32	IL-33	IL-13	77125(Tax:10090)	16163(Tax:10090)	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|production production|compound|END_ENTITY	Efficient cytokine-induced IL-13 production by mast cells requires both IL-33 and IL-3 .
24822215	0	IL-33	0,5	IL-13	64,69	IL-33	IL-13	90865	3596	Gene	Gene	enhanced|nsubj|START_ENTITY enhanced|dobj|production production|nmod|END_ENTITY	IL-33 enhanced the proliferation and constitutive production of IL-13 and IL-5 by fibrocytes .
26044350	0	IL-33	81,86	IL-13	71,76	IL-33	IL-13	77125(Tax:10090)	16163(Tax:10090)	Gene	Gene	ST2|compound|START_ENTITY END_ENTITY|nmod|ST2	Natural helper cells contribute to pulmonary_eosinophilia by producing IL-13 via IL-33 / ST2 pathway in a murine model of respiratory_syncytial_virus_infection .
26555705	0	IL-33	4,9	IL-13	41,46	IL-33	IL-13	77125(Tax:10090)	16163(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY regulates|nsubj|receptor regulates|dobj|production production|compound|END_ENTITY	The IL-33 receptor -LRB- ST2 -RRB- regulates early IL-13 production in fungus-induced allergic_airway_inflammation .
26833119	0	IL-33	14,19	IL-13	20,25	IL-33	IL-13	90865	3596	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting the IL-33 / IL-13 Axis for Respiratory Viral_Infections .
25017307	0	IL-33	16,21	IL-1RL1	22,29	IL-33	IL-1RL1	90865	9173	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|compound|END_ENTITY	The role of the IL-33 / IL-1RL1 axis in mast cell and basophil activation in allergic_disorders .
18450470	0	IL-33	58,63	IL-1_receptor_accessory_protein	4,35	IL-33	IL-1 receptor accessory protein	77125(Tax:10090)	16180(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nmod|signaling required|nsubjpass|END_ENTITY	The IL-1_receptor_accessory_protein -LRB- AcP -RRB- is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 .
23794184	0	IL-33	0,5	IL-31	6,11	IL-33	IL-31	90865	386653	Gene	Gene	START_ENTITY|appos|axis axis|nsubj|END_ENTITY	IL-33 / IL-31 axis : a new pathological mechanisms for EGFR tyrosine kinase inhibitors-associated skin_toxicity .
18802081	0	IL-33	0,5	IL-5	31,35	IL-33	IL-5	77125(Tax:10090)	16191(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|compound|END_ENTITY	IL-33 induces antigen-specific IL-5 + T cells and promotes allergic-induced airway inflammation independent of IL-4 .
21765905	0	IL-33	0,5	IL-9	14,18	IL-33	IL-9	90865	3578	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-33 induces IL-9 production in human CD4 + T cells and basophils .
26251474	0	IL-33	21,26	Oncostatin_M	0,12	IL-33	Oncostatin M	77125(Tax:10090)	18413(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Oncostatin_M induces IL-33 expression in liver endothelial cells in mice and expands ST2 + CD4 + lymphocytes .
26251474	0	IL-33	21,26	Oncostatin_M	0,12	IL-33	Oncostatin M	77125(Tax:10090)	18413(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Oncostatin_M induces IL-33 expression in liver endothelial cells in mice and expands ST2 + CD4 + lymphocytes .
18450470	0	IL-33	137,142	ST2	122,125	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	inhibit|dobj|START_ENTITY enhances|xcomp|inhibit enhances|dobj|ability ability|nmod|END_ENTITY	The IL-1_receptor_accessory_protein -LRB- AcP -RRB- is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 .
18827826	0	IL-33	4,9	ST2	10,13	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The IL-33 / ST2 pathway : therapeutic target and novel biomarker .
20662097	0	IL-33	59,64	ST2	20,23	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	transgenic_mice|nmod|START_ENTITY transgenic_mice|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of ST2 transgenic_mice with resistance to IL-33 .
21356240	0	IL-33	4,9	ST2	10,13	IL-33	ST2	90865	6761	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The IL-33 / ST2 pathway -- A new therapeutic target in cardiovascular_disease .
21703183	0	IL-33	19,24	ST2	25,28	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|nummod|END_ENTITY	Protective role of IL-33 / ST2 axis in Con A-induced hepatitis .
22233535	0	IL-33	12,17	ST2	35,38	IL-33	ST2	90865	6761	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic_rhinitis .
22349136	0	IL-33	6,11	ST2	20,23	IL-33	ST2	90865	6761	Gene	Gene	elevated|nsubj|START_ENTITY elevated|neg|not not|nmod:npmod|level level|nummod|END_ENTITY	Serum IL-33 but not ST2 level is elevated in intermittent_allergic_rhinitis and is a marker of the disease severity .
22392053	0	IL-33	0,5	ST2	6,9	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	START_ENTITY|appos|axis axis|nsubj|END_ENTITY	IL-33 / ST2 axis in inflammation and immunopathology .
22454393	0	IL-33	0,5	ST2	76,79	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|parataxis|improves improves|nsubj|END_ENTITY	IL-33 independently induces eosinophilic_pericarditis and cardiac_dilation : ST2 improves cardiac function .
22720252	0	IL-33	0,5	ST2	6,9	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|appos|axis axis|nsubj|END_ENTITY	IL-33 / ST2 axis in innate and acquired immunity to tumors .
23283516	0	IL-33	29,34	ST2	35,38	IL-33	ST2	90865	6761	Gene	Gene	role|nmod|START_ENTITY role|dep|system system|nummod|END_ENTITY	The evolutionary role of the IL-33 / ST2 system in host immune defence .
23300625	0	IL-33	11,16	ST2	17,20	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|parataxis|prolongs prolongs|nsubj|activation activation|nummod|END_ENTITY	Disordered IL-33 / ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy_loss .
23347081	0	IL-33	0,5	ST2	6,9	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	START_ENTITY|appos|contributes contributes|nsubj|signalling signalling|compound|END_ENTITY	IL-33 / ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain : role of cytokines , endothelin-1 and prostaglandin_E2 .
23484079	0	IL-33	34,39	ST2	40,43	IL-33	ST2	90865	6761	Gene	Gene	modulation|nmod|START_ENTITY modulation|dep|system system|nummod|END_ENTITY	Innate immunity modulation by the IL-33 / ST2 system in intestinal mucosa .
23662055	0	IL-33	133,138	ST2	139,142	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY induce|dobj|responses delivered|ccomp|induce Intravenously|acl|delivered Intravenously|parataxis|axis axis|nsubj|END_ENTITY	Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33 / ST2 axis .
23733876	0	IL-33	4,9	ST2	10,13	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	The IL-33 / ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis .
24045639	0	IL-33	4,9	ST2	10,13	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|axis axis|compound|END_ENTITY	The IL-33 / ST2 axis is associated with human visceral_leishmaniasis and suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania_donovani .
24122812	0	IL-33	14,19	ST2	37,40	IL-33	ST2	90865	6761	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of IL-33 and its receptor ST2 in chronic rhinosinusitis with nasal_polyps .
24385685	0	IL-33	0,5	ST2	6,9	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|appos|submitted submitted|nsubj|pathway pathway|nummod|END_ENTITY	IL-33 / ST2 pathway and classical cytokines in end-stage heart_failure patients submitted to left ventricular assist device support : a paradoxic role for inflammatory mediators ?
24446582	0	IL-33	12,17	ST2	18,21	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	Blockade|nmod|START_ENTITY Blockade|dep|ameliorates ameliorates|nummod|END_ENTITY	Blockade of IL-33 / ST2 ameliorates airway inflammation in a murine model of allergic_asthma .
24675360	0	IL-33	36,41	ST2	42,45	IL-33	ST2	90865	6761	Gene	Gene	deregulation|nmod|START_ENTITY deregulation|parataxis|progenitors progenitors|nsubj|pathway pathway|nummod|END_ENTITY	BCR-ABL-induced deregulation of the IL-33 / ST2 pathway in CD34 + progenitors from chronic_myeloid_leukemia patients .
24837094	0	IL-33	14,19	ST2	20,23	IL-33	ST2	361749(Tax:10116)	25556(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|dep|system system|nummod|END_ENTITY	Modulation of IL-33 / ST2 system in postinfarction heart_failure : correlation with cardiac remodelling markers .
25003325	0	IL-33	8,13	ST2	32,35	IL-33	ST2	90865	6761	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptor receptor|compound|END_ENTITY	Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic_pulmonary_arterial_hypertension .
25200162	0	IL-33	1,6	ST2	7,10	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	-LSB- IL-33 / ST2 promotes airway remodeling in asthma by activating the expression of fibronectin_1 and type 1 collagen in human lung fibroblasts -RSB- .
25280997	0	IL-33	0,5	ST2	6,9	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|appos|contributes contributes|nsubj|END_ENTITY	IL-33 / ST2 pathway contributes to metastasis of human colorectal_cancer .
25324197	0	IL-33	16,21	ST2	22,25	IL-33	ST2	90865	6761	Gene	Gene	Dynamics|nmod|START_ENTITY Dynamics|dep|network network|nummod|END_ENTITY	Dynamics of the IL-33 / ST2 network in the progression of human colorectal_adenoma_to_sporadic_colorectal_cancer .
25457999	0	IL-33	71,76	ST2	41,44	IL-33	ST2	90865	6761	Gene	Gene	action|nmod|START_ENTITY inhibiting|dobj|action enhances|advcl|inhibiting enhances|dobj|production production|nmod|END_ENTITY	Vitamin_D enhances production of soluble ST2 , inhibiting the action of IL-33 .
25517029	0	IL-33	33,38	ST2	39,42	IL-33	ST2	90865	6761	Gene	Gene	Associations|nmod|START_ENTITY Associations|dep|Genes Genes|compound|END_ENTITY	Associations between Variants in IL-33 / ST2 Signaling Pathway Genes and Coronary_Heart_Disease Risk .
25658420	0	IL-33	0,5	ST2	6,9	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|appos|correlates correlates|nsubj|END_ENTITY	IL-33 / ST2 correlates with severity of haemorrhagic_fever_with_renal_syndrome and regulates the inflammatory response in Hantaan_virus-infected endothelial cells .
25682948	0	IL-33	17,22	ST2	32,35	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY role|nmod|receptor END_ENTITY|nsubj|role	Critical role of IL-33 receptor ST2 in experimental_cerebral_malaria development .
25693767	0	IL-33	0,5	ST2	6,9	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	START_ENTITY|appos|involves involves|nsubj|END_ENTITY	IL-33 / ST2 involves the immunopathology of ocular_toxoplasmosis in murine model .
25721734	0	IL-33	0,5	ST2	16,19	IL-33	ST2	77125(Tax:10090)	6761	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	IL-33 receptor -LRB- ST2 -RRB- signaling is important for regulation of Th2-mediated airway inflammation in a murine model of acute_respiratory_syncytial_virus_infection .
25747940	0	IL-33	0,5	ST2	6,9	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|appos|controls controls|nsubj|axis axis|compound|END_ENTITY	IL-33 / ST2 axis controls Th2/IL -31 and Th17 immune response in allergic airway_diseases .
25798875	0	IL-33	0,5	ST2	18,21	IL-33	ST2	90865	6761	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	IL-33 and soluble ST2 levels as novel predictors for remission_and_progression_of_carotid_plaque in early rheumatoid_arthritis : A prospective study .
25881899	0	IL-33	22,27	ST2	28,31	IL-33	ST2	90865	6761	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	The potential role of IL-33 / ST2 signaling in fibrotic_diseases .
26277897	0	IL-33	4,9	ST2	10,13	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|axis axis|compound|END_ENTITY	The IL-33 / ST2 axis is specifically required for development of adipose tissue-resident regulatory T cells .
26343805	0	IL-33	22,27	ST2	28,31	IL-33	ST2	90865	6761	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|nummod|END_ENTITY	Potential role of the IL-33 / ST2 axis in celiac_disease .
26352378	0	IL-33	7,12	ST2	13,16	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	START_ENTITY|dep|Contributes Contributes|compound|END_ENTITY	Spinal IL-33 / ST2 Signaling Contributes to Neuropathic_Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice .
26417439	0	IL-33	60,65	ST2	66,69	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Atherosclerosis severity is not affected by a deficiency in IL-33 / ST2 signaling .
26555705	0	IL-33	4,9	ST2	20,23	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The IL-33 receptor -LRB- ST2 -RRB- regulates early IL-13 production in fungus-induced allergic_airway_inflammation .
26598236	0	IL-33	27,32	ST2	33,36	IL-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|Link Link|compound|END_ENTITY	Osteoprotective Effects of IL-33 / ST2 Link to Osteoclast Apoptosis .
26942077	0	IL-33	4,9	ST2	10,13	IL-33	ST2	90865	6761	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|END_ENTITY	The IL-33 / ST2 pathway contributes to intestinal tumorigenesis in humans and mice .
26944417	0	IL-33	34,39	ST2	40,43	IL-33	ST2	90865	17082(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Expression and potential roles of IL-33 / ST2 in the immune regulation during Clonorchis_sinensis_infection .
27031441	0	IL-33	44,49	ST2	18,21	IL-33	ST2	90865	6761	Gene	Gene	activity|compound|START_ENTITY Reconstitution|nmod|activity Reconstitution|nmod|specific specific|compound|END_ENTITY	Reconstitution of ST2 -LRB- IL-1R4 -RRB- specific for IL-33 activity ; no suppression by IL-1Ra though a common chain IL-1R3 -LRB- IL-1RAcP -RRB- shared with IL-1 .
20406635	0	IL-33	56,61	ST2L	62,66	IL-33	ST2L	90865	9173	Gene	Gene	model|nmod|START_ENTITY model|dep|axis axis|nummod|END_ENTITY	KU812 cells provide a novel in vitro model of the human IL-33 / ST2L axis : functional responses and identification of signaling pathways .
21949025	0	IL-33	0,5	ST2L	77,81	IL-33	ST2L	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	expands|dep|START_ENTITY expands|nmod|cells cells|nummod|+ +|compound|END_ENTITY	IL-33 expands suppressive CD11b + Gr-1 -LRB- int -RRB- and regulatory T cells , including ST2L + Foxp3 + cells , and mediates regulatory T cell-dependent promotion of cardiac allograft survival .
25662624	0	IL-33	12,17	ST2L	18,22	IL-33	ST2L	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|signals signals|nummod|END_ENTITY	The role of IL-33 / ST2L signals in the immune cells .
26679377	0	IL-33	32,37	ST2L	48,52	IL-33	ST2L	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	An antitumorigenic role for the IL-33 receptor , ST2L , in colon_cancer .
21887788	0	IL-33	0,5	TCR	22,25	IL-33	TCR	77125(Tax:10090)	328483(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8 + T cells .
22246057	0	IL-33	0,5	TNF-a	16,21	IL-33	TNF-a	90865	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|effects effects|amod|END_ENTITY	IL-33 regulates TNF-a dependent effects in synovial fibroblasts .
24522896	0	IL-33	0,5	TNF-a	22,27	IL-33	TNF-a	90865	7124	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	IL-33 is regulated by TNF-a in normal and psoriatic skin .
22961755	0	IL-33	39,44	TRAIL	0,5	IL-33	TRAIL	77125(Tax:10090)	22035(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TRAIL but not FasL and TNFa , regulates IL-33 expression in murine hepatocytes during acute_hepatitis .
21422152	0	IL-33	11,16	Th2	26,29	IL-33	Th2	77125(Tax:10090)	15111(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation .
23662055	0	IL-33	133,138	Th2	98,101	IL-33	Th2	77125(Tax:10090)	15111(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33 / ST2 axis .
26610488	0	IL-33	73,78	USP17	19,24	IL-33	USP17	90865	391627	Gene	Gene	Function|nmod|START_ENTITY Regulates|dobj|Function Regulates|nsubj|END_ENTITY	The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33 .
20160089	0	IL-33	0,5	VEGF	35,39	IL-33	VEGF	90865	7422	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|secretion secretion|amod|END_ENTITY	IL-33 augments substance_P-induced VEGF secretion from human mast cells and is increased in psoriatic skin .
20200353	0	IL-33	44,49	c-Kit	29,34	IL-33	c-Kit	90865	3815	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells .
26597162	0	IL-33	59,64	dual_oxidase_1	18,32	IL-33	dual oxidase 1	90865	53905	Gene	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Airway epithelial dual_oxidase_1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses .
21646790	0	IL-33	26,31	eotaxin	84,91	IL-33	eotaxin	77125(Tax:10090)	20292(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|induces induces|dobj|production production|compound|END_ENTITY	Expression and effects of IL-33 and ST2 in allergic bronchial_asthma : IL-33 induces eotaxin production in lung fibroblasts .
21646790	0	IL-33	70,75	eotaxin	84,91	IL-33	eotaxin	77125(Tax:10090)	20292(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Expression and effects of IL-33 and ST2 in allergic bronchial_asthma : IL-33 induces eotaxin production in lung fibroblasts .
26867960	0	IL-33	0,5	filaggrin	21,30	IL-33	filaggrin	90865	2312	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	IL-33 down-regulates filaggrin expression by inducing STAT3 and ERK phosphorylation in human keratinocytes .
24825247	0	IL-33	55,60	interleukin-33	39,53	IL-33	interleukin-33	90865	90865	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms of the interleukin-33 -LRB- IL-33 -RRB- gene are associated with ankylosing_spondylitis in Chinese individuals : a case-control pilot study .
23000728	0	IL-33	41,46	interleukin_33	25,39	IL-33	interleukin 33	90865	90865	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of interleukin_33 -LRB- IL-33 -RRB- in patients with eosinophilic_pneumonia .
22708120	0	IL-33	8,13	p65	54,57	IL-33	p65	90865	5970	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Nuclear IL-33 is a transcriptional regulator of NF-kB p65 and induces endothelial cell activation .
25930197	0	IL-33	92,97	receptor_for_advanced_glycation_end-products	10,54	IL-33	receptor for advanced glycation end-products	77125(Tax:10090)	177	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Pulmonary receptor_for_advanced_glycation_end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells .
22729249	0	IL-34	0,5	CSF1R	39,44	IL-34	CSF1R	76527(Tax:10090)	12978(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia .
22315422	0	IL-36_receptor	19,33	IL-38	0,5	IL-36 receptor	IL-38	8808	84639	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	IL-38 binds to the IL-36_receptor and has biological effects on immune cells similar to IL-36_receptor antagonist .
23527706	0	IL-36_receptor	0,14	IL-38	51,56	IL-36 receptor	IL-38	8808	84639	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	IL-36_receptor antagonist with special emphasis on IL-38 .
26221267	0	IL-37	73,78	ERK1/2	107,113	IL-37	ERK1/2	27178	5595	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Mannose-capped Lipoarabinomannan from Mycobacterium_tuberculosis induces IL-37 production via upregulating ERK1/2 and p38 in human type II alveolar epithelial cells .
26770645	0	IL-37	82,87	ERK1/2	116,122	IL-37	ERK1/2	27178	5595	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Erratum : Mannose-capped lipoarabinomannan from Mycobacterium_tuberculosis induces IL-37 production via upregulating ERK1/2 and p38 in human type II alveolar epithelial cells .
24788826	0	IL-37	17,22	IL-17A	51,57	IL-37	IL-17A	27178	3605	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of IL-37 and correlation with TNF-a , IL-17A , and disease activity during DMARD treatment of rheumatoid_arthritis .
24481253	0	IL-37	46,51	caspase-1	8,17	IL-37	caspase-1	27178	12362(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY Role|nmod|translocation Role|nmod|END_ENTITY	Role of caspase-1 in nuclear translocation of IL-37 , release of the cytokine , and IL-37 inhibition of innate immune responses .
22315422	0	IL-38	0,5	IL-36_receptor	19,33	IL-38	IL-36 receptor	84639	8808	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	IL-38 binds to the IL-36_receptor and has biological effects on immune cells similar to IL-36_receptor antagonist .
23527706	0	IL-38	51,56	IL-36_receptor	0,14	IL-38	IL-36 receptor	84639	8808	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	IL-36_receptor antagonist with special emphasis on IL-38 .
2972394	0	IL-4	0,4	B_cell_activating_factor	49,73	IL-4	B cell activating factor	16189(Tax:10090)	24099(Tax:10090)	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	IL-4 , but not IL-5 , can act synergistically with B_cell_activating_factor -LRB- BCAF -RRB- to induce proliferation of resting B cells .
11009091	0	IL-4	19,23	C/EBPbeta	0,9	IL-4	C/EBPbeta	16189(Tax:10090)	12608(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	C/EBPbeta enhances IL-4 but impairs IL-2 and IFN-gamma induction in T cells .
22226123	0	IL-4	0,4	CCL26	25,30	IL-4	CCL26	3565	10344	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1 , 2/Stat6 signal transduction pathway : Implication for atopic_dermatitis .
10201960	0	IL-4	107,111	CCR3	80,84	IL-4	CCR3	3565	1232	Gene	Gene	express|nmod|START_ENTITY express|dobj|END_ENTITY	Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 .
11160286	0	IL-4	96,100	CCR3	77,81	IL-4	CCR3	3565	1232	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	T cell phenotypes of the normal nasal mucosa : induction of Th2 cytokines and CCR3 expression by IL-4 .
19038554	0	IL-4	53,57	CCR3	34,38	IL-4	CCR3	3565	1232	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|silencing silencing|nmod|END_ENTITY	Post-transcriptional silencing of CCR3 downregulates IL-4 stimulated release of eotaxin-3 -LRB- CCL26 -RRB- and other CCR3 ligands in alveolar type II cells .
19781371	0	IL-4	124,128	CCR3	34,38	IL-4	CCR3	16189(Tax:10090)	12771(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY Expression|acl|induced Expression|nmod|cells cells|amod|receptors receptors|dep|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
7522293	0	IL-4	0,4	CD14	44,48	IL-4	CD14	3565	929	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	IL-4 inhibits the LPS-induced expression of CD14 and monocyte-specific esterase mRNA in MONO-MAC-6 cells .
11884427	0	IL-4	30,34	CD209	9,14	IL-4	CD209	3565	30835	Gene	Gene	dependent|advmod|START_ENTITY dependent|dep|END_ENTITY	DC-SIGN -LRB- CD209 -RRB- expression is IL-4 dependent and is negatively regulated by IFN , TGF-beta , and anti-inflammatory agents .
8133030	0	IL-4	33,37	CD23	14,18	IL-4	CD23	3565	2208	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CD23 expression by IL-4 and corticosteroid in human B lymphocytes .
12218142	0	IL-4	10,14	CD25	171,175	IL-4	CD25	16189(Tax:10090)	16184(Tax:10090)	Gene	Gene	response|compound|START_ENTITY subject|nsubj|response subject|nmod|control control|nmod|cells cells|compound|END_ENTITY	The early IL-4 response to Leishmania_major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 + CD25 + T cells .
16237107	0	IL-4	4,8	CD25	99,103	IL-4	CD25	16189(Tax:10090)	16184(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY alpha-chain-binding|nsubj|receptor alpha-chain-binding|ccomp|induce induce|dobj|cells cells|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16237107	0	IL-4	49,53	CD25	99,103	IL-4	CD25	16189(Tax:10090)	16184(Tax:10090)	Gene	Gene	cytokines|appos|START_ENTITY induce|nsubj|cytokines induce|dobj|cells cells|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
10421790	0	IL-4	77,81	CD28	99,103	IL-4	CD28	3565	940	Gene	Gene	prevents|nsubj|START_ENTITY prevents|dobj|loss loss|nmod|expression expression|compound|END_ENTITY	Peripheral human CD8 -LRB- + -RRB- CD28 -LRB- + -RRB- T lymphocytes give rise to CD28 -LRB- - -RRB- progeny , but IL-4 prevents loss of CD28 expression .
10604995	0	IL-4	14,18	CD28	140,144	IL-4	CD28	3565	940	Gene	Gene	responses|compound|START_ENTITY Inhibition|nmod|responses reversed|nsubjpass|Inhibition reversed|nmod|presence presence|nmod|costimulation costimulation|compound|END_ENTITY	Inhibition of IL-4 responses after T cell priming in the context of LFA-1 costimulation is not reversed by restimulation in the presence of CD28 costimulation .
10725744	0	IL-4	54,58	CD28	90,94	IL-4	CD28	3565	940	Gene	Gene	expression|compound|START_ENTITY mediate|dobj|expression mediate|nmod|costimulation costimulation|nummod|END_ENTITY	Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells .
11254680	0	IL-4	84,88	CD28	63,67	IL-4	CD28	3565	940	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression differentiation|dep|regulation differentiation|nmod|stimulation stimulation|nmod|END_ENTITY	Antigen-independent Th2 cell differentiation by stimulation of CD28 : regulation via IL-4 gene expression and mitogen-activated protein kinase activation .
15569772	0	IL-4	54,58	CD28	40,44	IL-4	CD28	16189(Tax:10090)	12487(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY drive|dobj|expression capacity|acl|drive capacity|nmod|ligands ligands|nmod|END_ENTITY	The capacity of the natural ligands for CD28 to drive IL-4 expression in na ve and antigen-primed CD4 + and CD8 + T cells .
1646626	0	IL-4	0,4	CD28	93,97	IL-4	CD28	16189(Tax:10090)	12487(Tax:10090)	Gene	Gene	upregulate|nsubj|START_ENTITY counterstructure|ccomp|upregulate counterstructure|xcomp|T T|dobj|END_ENTITY	IL-4 and IL-2 upregulate the expression of antigen B7 , the B cell counterstructure to T cell CD28 : an amplification mechanism for T-B cell interactions .
9126966	0	IL-4	45,49	CD28	0,4	IL-4	CD28	16189(Tax:10090)	12487(Tax:10090)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response .
2570801	0	IL-4	69,73	CD29	81,85	IL-4	CD29	3565	3688	Gene	Gene	START_ENTITY|nmod|CD45R CD45R|compound|END_ENTITY	Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4 + CD29 + CD45R - memory T lymphocytes .
25999672	0	IL-4	14,18	CD30	70,74	IL-4	CD30	3565	943	Gene	Gene	Intracellular|dobj|START_ENTITY Intracellular|nmod|characteristic characteristic|nmod|cells cells|compound|END_ENTITY	Intracellular IL-4 , IL-5 , and IFN-y as the main characteristic of CD4 + CD30 + T cells after allergen stimulation in patients with vernal_keratoconjunctivitis .
9036953	0	IL-4	60,64	CD30	25,29	IL-4	CD30	3565	943	Gene	Gene	T|nmod|START_ENTITY T|nsubj|regulation regulation|nmod|expression expression|nummod|END_ENTITY	Reciprocal regulation of CD30 expression on CD4 + T cells by IL-4 and IFN-gamma .
7685706	0	IL-4	72,76	CD34	84,88	IL-4	CD34	3565	947	Gene	Gene	START_ENTITY|nmod|subset subset|compound|END_ENTITY	Effects of interleukin-4 on myelopoiesis : localization of the action of IL-4 in the CD34 + HLA-DR + + subset and distinction between direct and indirect effects of IL-4 .
10227987	0	IL-4	176,180	CD4	52,55	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	amounts|nmod|START_ENTITY secrete|dobj|amounts capacity|acl|secrete mice|nmod|capacity exist|nmod|mice exist|nsubj|NK1.1-negative NK1.1-negative|appos|alpha alpha|dep|cells cells|compound|END_ENTITY	Splenic NK1.1-negative , TCR alpha beta intermediate CD4 + T cells exist in naive NK1 .1 allelic positive and negative mice , with the capacity to rapidly secrete large amounts of IL-4 and IFN-gamma upon primary TCR stimulation .
10323213	0	IL-4	72,76	CD4	105,108	IL-4	CD4	3565	920	Gene	Gene	vitro|nmod|START_ENTITY thymocytes|acl|vitro Differentiation|nmod|thymocytes Differentiation|dep|+ +|compound|END_ENTITY	Differentiation of human single-positive fetal thymocytes in vitro into IL-4 - and/or IFN-gamma-producing CD4 + and CD8 + T cells .
10358149	0	IL-4	18,22	CD4	94,97	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY up-regulates|dobj|production up-regulates|nmod|cells cells|amod|NK1 NK1|dep|I-like/CD1-dependent I-like/CD1-dependent|dep|T T|compound|END_ENTITY	IL-7 up-regulates IL-4 production by splenic NK1 .1 + and NK1 .1 - MHC class I-like/CD1-dependent CD4 + T cells .
10358155	0	IL-4	103,107	CD4	128,131	IL-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nmod|cells cells|compound|END_ENTITY	p38_alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4 + CD45RO + T cells and Th2 effector cells .
10403909	0	IL-4	8,12	CD4	60,63	IL-4	CD4	3565	920	Gene	Gene	expression|nsubj|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Reduced IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- expression by CD4 T cells in patients with chronic_lymphocytic_leukaemia .
10454344	0	IL-4	176,180	CD4	107,110	IL-4	CD4	280824(Tax:9913)	407098(Tax:9913)	Gene	Gene	has|nsubj|START_ENTITY enhances|advcl|has T|parataxis|enhances T|nsubj|effects effects|nmod|interleukin-12 interleukin-12|nmod|responses responses|nmod|+ +|compound|END_ENTITY	Comparative effects of interleukin-12 and interleukin-4 on cytokine responses by antigen-stimulated memory CD4 + T cells of cattle : IL-12 enhances IFN-gamma production , whereas IL-4 has marginal effects on cytokine expression .
10465051	0	IL-4	67,71	CD4	0,3	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	CD4 + and/or gammadelta + T cells in the liver spontaneously produce IL-4 in vitro during the early phase of Leishmania_major_infection in susceptible BALB/c mice .
10549628	0	IL-4	95,99	CD4	13,16	IL-4	CD4	3565	920	Gene	Gene	using|dobj|START_ENTITY protect|xcomp|using T|acl:relcl|protect T|compound|END_ENTITY	Autoreactive CD4 + T cells protect from autoimmune diabetes via bystander suppression using the IL-4 / Stat6 pathway .
10706693	0	IL-4	34,38	CD4	123,126	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor/Stat6|compound|START_ENTITY required|nsubjpass|receptor/Stat6 required|nmod|development development|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4 + lymphocytes with a Th2 cytokine profile .
10789989	0	IL-4	104,108	CD4	69,72	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|Immunoregulation Immunoregulation|nmod|cells cells|compound|END_ENTITY	Immunoregulation of encephalitogenic MBP-NAc1-11-reactive T cells by CD4 + TCR-specific T cells involves IL-4 , IL-10 and IFN-gamma .
10975998	0	IL-4	30,34	CD4	61,64	IL-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Modulatory roles of RANTES in IL-4 production by human blood CD4 -LRB- + -RRB- T cells .
11034364	0	IL-4	62,66	CD4	20,23	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY provide|dobj|source provide|nsubj|cells cells|amod|naive naive|dep|END_ENTITY	Conventional , naive CD4 + T cells provide an initial source of IL-4 during Th2 differentiation .
11067920	0	IL-4	114,118	CD4	82,85	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	secrete|dobj|START_ENTITY cells|acl|secrete cells|compound|END_ENTITY	Priming by microbial antigens from the intestinal flora determines the ability of CD4 + T cells to rapidly secrete IL-4 in BALB/c mice infected with Leishmania_major .
11359851	0	IL-4	129,133	CD4	27,30	IL-4	CD4	3565	920	Gene	Gene	cells|nmod|START_ENTITY subset|nmod|cells defines|dobj|subset defines|nsubj|CCR4 CCR4|nmod|cells cells|nummod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11449377	0	IL-4	50,54	CD4	131,134	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY polarization|nmod|absence polarization|parataxis|regulates regulates|nmod|cytokines cytokines|nmod|cells cells|compound|END_ENTITY	Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12 : T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells .
11751746	0	IL-4	4,8	CD4	61,64	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	capability|compound|START_ENTITY capability|nmod|strains strains|nmod|T T|compound|END_ENTITY	The IL-4 production capability of different strains of naive CD4 -LRB- + -RRB- T cells controls the direction of the T -LRB- h -RRB- cell response .
11781715	0	IL-4	25,29	CD4	65,68	IL-4	CD4	3565	920	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|cells cells|compound|END_ENTITY	Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells .
11796615	0	IL-4	130,134	CD4	47,50	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY lymphocytes|dep|induction lymphocytes|dep|END_ENTITY	Fas_ligand-expressing B-1a lymphocytes mediate CD4 -LRB- + -RRB- - T-cell apoptosis during schistosomal_infection : induction by interleukin_4 -LRB- IL-4 -RRB- and IL-10 .
11859105	0	IL-4	115,119	CD4	65,68	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY generates|xcomp|expressing generates|dobj|cells cells|compound|END_ENTITY	Administration of an antigen at a high dose generates regulatory CD4 + T cells expressing CD95 ligand and secreting IL-4 in the liver .
11971011	0	IL-4	6,10	CD4	72,75	IL-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY production|nmod|homolog homolog|nmod|END_ENTITY	Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4 -LRB- + -RRB- T cells in resistant mice treated once with anti-IL-12 or - IFN-gamma antibodies at the onset of infection with Leishmania_major instructs Th2 cell development , resulting in nonhealing lesions .
11971026	0	IL-4	36,40	CD4	76,79	IL-4	CD4	3565	920	Gene	Gene	release|compound|START_ENTITY release|nmod|eosinophils eosinophils|nmod|END_ENTITY	IL-16 promotes leukotriene_C -LRB- 4 -RRB- and IL-4 release from human eosinophils via CD4 - and autocrine CCR3-chemokine-mediated signaling .
11981811	0	IL-4	121,125	CD4	91,94	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY dependent|nmod|source dependent|nmod|cells cells|compound|END_ENTITY	Th2-type granuloma development in acute murine schistosomiasis is only partly dependent on CD4 + T cells as the source of IL-4 .
11981831	0	IL-4	0,4	CD4	36,39	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	secreted|nsubj|START_ENTITY secreted|nmod|acts acts|compound|END_ENTITY	IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation .
12218142	0	IL-4	10,14	CD4	167,170	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY subject|nsubj|response subject|nmod|control control|nmod|cells cells|compound|END_ENTITY	The early IL-4 response to Leishmania_major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 + CD25 + T cells .
12220104	0	IL-4	122,126	CD4	25,28	IL-4	CD4	3565	920	Gene	Gene	production|nmod|START_ENTITY cells|dep|production T|dobj|cells T|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of CD3 + CD4 - CD8 - -LRB- double negative -RRB- T cells in patients with systemic_lupus_erythematosus : production of IL-4 .
12444170	0	IL-4	47,51	CD4	62,65	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	IFN-gamma|dep|START_ENTITY Th2|appos|IFN-gamma Th2|acl:relcl|cell cell|compound|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12534941	0	IL-4	0,4	CD4	16,19	IL-4	CD4	287287(Tax:10116)	24932(Tax:10116)	Gene	Gene	START_ENTITY|amod|responsive responsive|dep|END_ENTITY	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
12568118	0	IL-4	10,14	CD4	25,28	IL-4	CD4	3565	920	Gene	Gene	START_ENTITY|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	Decreased IL-4 producing CD4 + T cells in patients with active systemic_lupus_erythematosus-relation to IL-12R expression .
12594266	0	IL-4	96,100	CD4	121,124	IL-4	CD4	3565	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Role of TCR-induced extracellular_signal-regulated_kinase activation in the regulation of early IL-4 expression in naive CD4 + T cells .
12848849	0	IL-4	97,101	CD4	115,118	IL-4	CD4	3565	920	Gene	Gene	development|nmod|START_ENTITY required|nmod|development required|xcomp|synthesizing synthesizing|dobj|cells cells|nummod|END_ENTITY	Sustained linked stimulation via CD3 and CD4 is required for the IL-4-independent development of IL-4 synthesizing CD4 + T cells .
1353098	0	IL-4	38,42	CD4	46,49	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	respond|nmod|START_ENTITY respond|nmod|type type|compound|END_ENTITY	Induction of competence to respond to IL-4 by CD4 + T helper type 1 cells requires costimulation .
1357029	0	IL-4	40,44	CD4	69,72	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4 + cells correlate with resolution of lesions in murine cutaneous_leishmaniasis .
1361075	0	IL-4	53,57	CD4	23,26	IL-4	CD4	3565	920	Gene	Gene	presence|nmod|START_ENTITY cells|nmod|presence cells|nummod|END_ENTITY	Primary stimulation of CD4 + cells in the presence of IL-4 or IFN-gamma alters the frequencies of cytokine-producing cells at restimulation .
15326095	0	IL-4	0,4	CD4	75,78	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY impair|nsubj|deficiency impair|advcl|initiate initiate|dobj|+ +|compound|END_ENTITY	IL-4 deficiency does not impair the ability of dendritic cells to initiate CD4 + and CD8 + T cell responses in vivo .
15944265	0	IL-4	0,4	CD4	19,22	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	modulation|compound|START_ENTITY modulation|nmod|suppression suppression|compound|END_ENTITY	IL-4 modulation of CD4 + CD25 + T regulatory cell-mediated suppression .
16237062	0	IL-4	165,169	CD4	195,198	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increase|dobj|expression increase|nmod|cells cells|compound|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- deficiency in macrophages results in increased stimulation of CD4 + T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4 + T cells independent of antigen presentation .
16237062	0	IL-4	165,169	CD4	96,99	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increase|dobj|expression deficiency|advcl|increase deficiency|nmod|results results|nmod|stimulation stimulation|nmod|cells cells|compound|END_ENTITY	Estrogen_receptor_alpha -LRB- ERalpha -RRB- deficiency in macrophages results in increased stimulation of CD4 + T cells while 17beta-estradiol acts through ERalpha to increase IL-4 and GATA-3 expression in CD4 + T cells independent of antigen presentation .
16237107	0	IL-4	4,8	CD4	104,107	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY alpha-chain-binding|nsubj|receptor alpha-chain-binding|ccomp|induce induce|dobj|cells cells|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16237107	0	IL-4	49,53	CD4	104,107	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytokines|appos|START_ENTITY induce|nsubj|cytokines induce|dobj|cells cells|compound|END_ENTITY	The IL-4 receptor alpha-chain-binding cytokines , IL-4 and IL-13 , induce forkhead_box_P3-expressing CD25 + CD4 + regulatory T cells from CD25-CD4 + precursors .
16272288	0	IL-4	29,33	CD4	17,20	IL-4	CD4	3565	920	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Morphine induces CD4 + T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway .
1674955	0	IL-4	0,4	CD4	103,106	IL-4	CD4	3565	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|chain chain|nmod|cells cells|nummod|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
16806176	0	IL-4	91,95	CD4	123,126	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	STAT6|compound|START_ENTITY dependent|nmod|STAT6 dependent|xcomp|signaling signaling|dobj|cells cells|amod|pathway pathway|nmod|T T|compound|END_ENTITY	Immune-mediated neuroprotection of axotomized mouse facial_motoneurons is dependent on the IL-4 / STAT6 signaling pathway in CD4 -LRB- + -RRB- T cells .
17035345	0	IL-4	99,103	CD4	124,127	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY capacity|nmod|production controlling|dobj|capacity controlling|nmod|cells cells|compound|END_ENTITY	Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4 + T cells .
17075267	0	IL-4	55,59	CD4	16,19	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY cells|dobj|downregulation cells|nsubj|T T|compound|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
17085308	0	IL-4	40,44	CD4	61,64	IL-4	CD4	287287(Tax:10116)	24932(Tax:10116)	Gene	Gene	polarized|nsubj|START_ENTITY polarized|dobj|cells cells|compound|END_ENTITY	Phase I clinical trial of costimulated , IL-4 polarized donor CD4 + T cells as augmentation of allogeneic hematopoietic cell transplantation .
17237387	0	IL-4	13,17	CD4	32,35	IL-4	CD4	3565	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of IL-4 expression in CD4 -LRB- + -RRB- T cells by thymic stromal lymphopoietin .
17404269	0	IL-4	87,91	CD4	106,109	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY mediation|nmod|generation Type|dobj|mediation Type|nmod|cells cells|compound|END_ENTITY	Type 1 sphingosine_1-phosphate G protein-coupled receptor -LRB- S1P1 -RRB- mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic_mice .
17404901	0	IL-4	0,4	CD4	39,42	IL-4	CD4	3565	920	Gene	Gene	inducibility|nsubj|START_ENTITY inducibility|xcomp|ve ve|dobj|cells cells|nummod|END_ENTITY	IL-4 inducibility in NKT cells , na ve CD4 + T cells and TCR-gamma delta T cells .
17675505	0	IL-4	69,73	CD4	105,108	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY reveal|nsubj|mice reveal|dobj|cells cells|nummod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17675505	0	IL-4	69,73	CD4	18,21	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY reveal|nsubj|mice reveal|nmod|cells cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
17709489	0	IL-4	33,37	CD4	0,3	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	alpha|compound|START_ENTITY deletion|nmod|alpha deletion|compound|END_ENTITY	CD4 + T cell-specific deletion of IL-4 receptor alpha prevents ovalbumin-induced anaphylaxis by an IFN-gamma-dependent mechanism .
17709492	0	IL-4	85,89	CD4	81,84	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD8 + T cell-mediated airway_hyperresponsiveness and inflammation is dependent on CD4 + IL-4 + T cells .
17883452	0	IL-4	127,131	CD4	47,50	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY capacity|acl|express develop|dobj|capacity cognate|advcl|develop responding|xcomp|cognate cells|acl|responding T|dep|cells T|compound|END_ENTITY	Feeding by the tick , Ixodes_scapularis , causes CD4 -LRB- + -RRB- T cells responding to cognate antigen to develop the capacity to express IL-4 .
18453568	0	IL-4	43,47	CD4	22,25	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Imprinting Imprinting|nmod|CCR9 CCR9|nmod|cells cells|compound|END_ENTITY	Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells .
18591677	0	IL-4	74,78	CD4	45,48	IL-4	CD4	3565	920	Gene	Gene	precursors|compound|START_ENTITY derived|nmod|precursors lymphocytes|acl|derived lymphocytes|compound|END_ENTITY	Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors .
19003207	0	IL-4	103,107	CD4	153,156	IL-4	CD4	3565	920	Gene	Gene	Production|nmod|START_ENTITY Induce|dobj|Production Induce|nmod|Cultures Cultures|nmod|Cells Cells|compound|END_ENTITY	Dendritic Cells from Spleen , Mesenteric Lymph Node and Peyer 's Patch Can Induce the Production of Both IL-4 and IFN-gamma from Primary Cultures of Naive CD4 -LRB- + -RRB- T Cells in a Dose-Dependent Manner .
19036925	0	IL-4	118,122	CD4	0,3	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY initiation|nmod|production inhibiting|dobj|initiation suppresses|advcl|inhibiting cytokine|ccomp|suppresses cytokine|nsubj|cell-secreted cell-secreted|nummod|END_ENTITY	CD4 cell-secreted , posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production .
1911543	0	IL-4	86,90	CD4	48,51	IL-4	CD4	3565	920	Gene	Gene	cultured|nmod|START_ENTITY clones|acl|cultured expressed|dobj|clones expressed|nmod|T T|compound|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
19493208	0	IL-4	88,92	CD4	65,68	IL-4	CD4	3565	920	Gene	Gene	express|dobj|START_ENTITY host|xcomp|express host|dobj|cells cells|compound|END_ENTITY	SAAG-4 is a novel mosquito salivary protein that programmes host CD4 T cells to express IL-4 .
1968430	0	IL-4	45,49	CD4	65,68	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|populations populations|compound|END_ENTITY	Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4 + populations .
19781371	0	IL-4	124,128	CD4	58,61	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY Expression|acl|induced Expression|nmod|cells cells|amod|receptors receptors|nmod|T T|compound|END_ENTITY	Expression of chemokine receptors CCR3 , CCR5 and CXCR3 on CD4 -LRB- + -RRB- T cells in CBA/JxDBA/2 mouse model , selectively induced by IL-4 and IL-10 , regulates the embryo resorption rate .
20010912	0	IL-4	30,34	CD4	55,58	IL-4	CD4	3565	920	Gene	Gene	requirements|nmod|START_ENTITY requirements|parataxis|signalling signalling|nmod|determination determination|compound|END_ENTITY	Differential requirements for IL-4 / STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses .
20392496	0	IL-4	0,4	CD4	18,21	IL-4	CD4	3565	920	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|END_ENTITY	IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro , but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo .
20495070	0	IL-4	97,101	CD4	74,77	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY unmasks|dobj|production unmasks|nsubj|lack lack|nmod|competition competition|nmod|peptide peptide|nmod|responses responses|compound|END_ENTITY	Cutting edge : lack of high affinity competition for peptide in polyclonal CD4 + responses unmasks IL-4 production .
20812238	0	IL-4	104,108	CD4	53,56	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY IL-10|nmod|production cells|nmod|IL-10 modulate|dobj|cells modulate|iobj|production production|nmod|T T|compound|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20812238	0	IL-4	104,108	CD4	6,9	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY IL-10|nmod|production cells|nmod|IL-10 modulate|dobj|cells T|ccomp|modulate T|nsubj|END_ENTITY	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
20869773	0	IL-4	18,22	CD4	57,60	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	Neutralization|nmod|START_ENTITY reverses|nsubj|Neutralization reverses|dobj|nonresponsiveness nonresponsiveness|nmod|cells cells|compound|END_ENTITY	Neutralization of IL-4 reverses the nonresponsiveness of CD4 + T cells to regulatory T-cell induction in non-responder mouse strains .
20980261	0	IL-4	96,100	CD4	68,71	IL-4	CD4	3565	920	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|cells cells|compound|END_ENTITY	Inhibition of suppressive T_cell_factor_1 -LRB- TCF-1 -RRB- isoforms in naive CD4 + T cells is mediated by IL-4 / STAT6 signaling .
2105169	0	IL-4	51,55	CD4	22,25	IL-4	CD4	3565	920	Gene	Gene	cloned|nmod|START_ENTITY cloned|nsubj|analysis analysis|nmod|cells cells|compound|END_ENTITY	Frequency analysis of CD4 + CD8 + T cells cloned with IL-4 .
21282512	0	IL-4	29,33	CD4	93,96	IL-4	CD4	3565	920	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression regulated|nsubjpass|Induction regulated|nmod|cells cells|compound|END_ENTITY	Induction and maintenance of IL-4 expression are regulated differently by the 3 ' enhancer in CD4 T cells .
23545299	0	IL-4	60,64	CD4	74,77	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	interleukin-4|appos|START_ENTITY induce|iobj|interleukin-4 induce|dobj|T T|compound|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
23675066	0	IL-4	18,22	CD4	68,71	IL-4	CD4	3565	920	Gene	Gene	Neutralization|nmod|START_ENTITY Neutralization|acl|inducing inducing|dobj|Foxp3 Foxp3|compound|END_ENTITY	Neutralization of IL-4 and IFN-y Facilitates inducing TGF-b-induced CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Regulatory Cells .
23958647	0	IL-4	0,4	CD4	57,60	IL-4	CD4	3565	920	Gene	Gene	confers|nsubj|START_ENTITY confers|nmod|suppression suppression|nmod|cells cells|compound|END_ENTITY	IL-4 confers resistance to IL-27-mediated suppression on CD4 + T cells by impairing signal_transducer_and_activator_of_transcription_1 signaling .
23997222	0	IL-4	15,19	CD4	125,128	IL-4	CD4	3565	920	Gene	Gene	secretion|compound|START_ENTITY induces|dobj|secretion induces|nmod|expression expression|nmod|receptor receptor|nmod|cells cells|compound|END_ENTITY	HLA-G5 induces IL-4 secretion critical for successful pregnancy through differential expression of ILT2 receptor on decidual CD4 T cells and macrophages .
24089996	0	IL-4	155,159	CD4	123,126	IL-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY responses|nmod|production T|dep|responses T|compound|END_ENTITY	The 30-kDa and 38-kDa antigens from Mycobacterium_tuberculosis induce partial maturation of human dendritic cells shifting CD4 -LRB- + -RRB- T cell responses towards IL-4 production .
24778440	0	IL-4	92,96	CD4	0,3	IL-4	CD4	3565	920	Gene	Gene	program|compound|START_ENTITY run|dobj|program poised|xcomp|run poised|nsubjpass|cells cells|nummod|END_ENTITY	CD4 + T cells from human neonates and infants are poised spontaneously to run a nonclassical IL-4 program .
25108019	0	IL-4	59,63	CD4	43,46	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY prime|nmod|production prime|dobj|cells cells|nummod|END_ENTITY	Helminth-conditioned dendritic cells prime CD4 + T cells to IL-4 production in vivo .
25607842	0	IL-4	63,67	CD4	18,21	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	neurons|nmod|START_ENTITY protect|dobj|neurons +|ccomp|protect +|nsubj|END_ENTITY	MHCII-independent CD4 + T cells protect injured CNS neurons via IL-4 .
2570801	0	IL-4	69,73	CD4	77,80	IL-4	CD4	3565	920	Gene	Gene	START_ENTITY|nmod|CD45R CD45R|compound|END_ENTITY	Stimulation via the CD3 and CD28 molecules induces responsiveness to IL-4 in CD4 + CD29 + CD45R - memory T lymphocytes .
25938785	0	IL-4	63,67	CD4	18,21	IL-4	CD4	3565	920	Gene	Gene	neurons|nmod|START_ENTITY protect|dobj|neurons +|ccomp|protect +|nsubj|END_ENTITY	MHCII-independent CD4 + T cells protect injured CNS neurons via IL-4 .
25999672	0	IL-4	14,18	CD4	66,69	IL-4	CD4	3565	920	Gene	Gene	Intracellular|dobj|START_ENTITY Intracellular|nmod|characteristic characteristic|nmod|cells cells|compound|END_ENTITY	Intracellular IL-4 , IL-5 , and IFN-y as the main characteristic of CD4 + CD30 + T cells after allergen stimulation in patients with vernal_keratoconjunctivitis .
7530038	0	IL-4	32,36	CD4	90,93	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	establishment|nmod|START_ENTITY establishment|dep|profile profile|nmod|response response|compound|END_ENTITY	Rapid establishment of a stable IL-4 / IFN-gamma production profile in the antigen-specific CD4 + T cell response to protein immunization .
7586698	0	IL-4	51,55	CD4	61,64	IL-4	CD4	3565	920	Gene	Gene	production|nmod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Spontaneous production of various cytokines except IL-4 from CD4 + T cells in the affected organs of sarcoidosis patients .
7602091	0	IL-4	33,37	CD4	75,78	IL-4	CD4	3565	920	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4 + T lymphocytes .
7808764	0	IL-4	140,144	CD4	87,90	IL-4	CD4	287287(Tax:10116)	24932(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY OX22|dep|secretion OX22|compound|END_ENTITY	Cytokine profile of protective anti-Trichinella_spiralis CD4 + OX22 - and non-protective CD4 + OX22 + thoracic duct cells in rats : secretion of IL-4 alone does not determine protective capacity .
7819141	0	IL-4	18,22	CD4	58,61	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	cAMP up-regulates IL-4 and IL-5 production from activated CD4 + T cells while decreasing IL-2 release and NF-AT induction .
7876534	0	IL-4	15,19	CD4	66,69	IL-4	CD4	3565	920	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|cells cells|compound|END_ENTITY	IL-12 inhibits IL-4 synthesis in keyhole limpet hemocyanin-primed CD4 + T cells through an effect on antigen-presenting cells .
7902131	0	IL-4	19,23	CD4	64,67	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY sensitivity|nmod|production lost|nsubjpass|sensitivity lost|nmod|cells cells|compound|END_ENTITY	The sensitivity of IL-4 production for cAMP inducers is lost in CD4 + T cells from aged mice .
7911751	0	IL-4	62,66	CD4	94,97	IL-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY production|nmod|feature feature|nmod|differentiation differentiation|compound|END_ENTITY	Age-related increase in the fraction of CD27-CD4 + T cells and IL-4 production as a feature of CD4 + T cell differentiation in vivo .
7912705	0	IL-4	123,127	CD4	70,73	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY differ|nmod|production subsets|acl:relcl|differ subsets|compound|END_ENTITY	Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production .
8327860	0	IL-4	97,101	CD4	36,39	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY treated|nmod|receptor transfer|acl|treated transfer|nmod|numbers numbers|nmod|cells cells|nummod|END_ENTITY	Adoptive transfer of low numbers of CD4 + T cells into SCID mice chronically treated with soluble IL-4 receptor does not prevent engraftment of IL-4-producing T cells .
8580071	0	IL-4	0,4	CD4	15,18	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|producing producing|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	IL-4 producing CD4 + TCR alpha beta int liver lymphocytes : influence of thymus , beta_2-microglobulin and NK1 .1 expression .
8613355	0	IL-4	36,40	CD4	123,126	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	interleukin-4|appos|START_ENTITY immunization|nmod|interleukin-4 reveals|nsubj|immunization reveals|ccomp|associated associated|nsubjpass|cells cells|nummod|+ +|compound|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8617933	0	IL-4	112,116	CD4	42,45	IL-4	CD4	3565	920	Gene	Gene	synthesis|compound|START_ENTITY signal|dobj|synthesis generates|ccomp|signal generates|nsubj|Cross-linking Cross-linking|nmod|CD40_ligand CD40_ligand|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Cross-linking of the CD40_ligand on human CD4 + T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis .
8921430	0	IL-4	67,71	CD4	109,112	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes .
8992977	0	IL-4	15,19	CD4	131,134	IL-4	CD4	3565	920	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|phenotype phenotype|nmod|cells cells|amod|END_ENTITY	T cell-derived IL-4 and dendritic cell-derived IL-12 regulate the lymphokine-producing phenotype of alloantigen-primed naive human CD4 T cells .
9120316	0	IL-4	14,18	CD4	56,59	IL-4	CD4	3565	920	Gene	Gene	mRNA|compound|START_ENTITY Expression|nmod|mRNA Expression|nmod|+ +|compound|END_ENTITY	Expression of IL-4 and IL-5 mRNA and protein product by CD4 + and CD8 + T cells , eosinophils , and mast cells in bronchial biopsies obtained from atopic_and_nonatopic _ -LRB- intrinsic -RRB- _ asthmatics .
9126977	0	IL-4	71,75	CD4	47,50	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY induce|xcomp|produce induce|dobj|cells cells|compound|END_ENTITY	Antigen-specific B cells preferentially induce CD4 + T cells to produce IL-4 .
9200431	0	IL-4	0,4	CD4	18,21	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	IL-4 secretion by CD4 + NK1 + T cells induces monocyte_chemoattractant_protein-1 in early listeriosis .
9278312	0	IL-4	54,58	CD4	16,19	IL-4	CD4	3565	920	Gene	Gene	amounts|nmod|START_ENTITY produce|dobj|amounts produce|nsubj|cells cells|compound|END_ENTITY	Cultured NK1 .1 + CD4 + T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1 .
9341744	0	IL-4	49,53	CD4	13,16	IL-4	CD4	3565	920	Gene	Gene	lymphocytes|dobj|START_ENTITY lymphocytes|nsubj|Detection Detection|nmod|T T|compound|END_ENTITY	Detection of CD4 + CD45RO + T lymphocytes producing IL-4 in response to antigens on Plasmodium_falciparum erythrocytes : an in vitro correlate of protective immunity induced with attenuated Plasmodium_falciparum sporozoites .
9380721	0	IL-4	18,22	CD4	48,51	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	interleukin_4|appos|START_ENTITY interleukin_4|dep|mice mice|amod|independent independent|ccomp|revealed revealed|nsubjpass|production production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9380721	0	IL-4	60,64	CD4	48,51	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9380721	0	IL-4	91,95	CD4	48,51	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	revealed|nmod|START_ENTITY revealed|nsubjpass|production production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9438489	0	IL-4	29,33	CD4	88,91	IL-4	CD4	3565	920	Gene	Gene	contribution|nmod|START_ENTITY induced|nsubj|contribution induced|nmod|+ +|compound|END_ENTITY	The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4 + or CD8 + T cells .
9620597	0	IL-4	79,83	CD4	45,48	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY requires|dobj|production requires|nsubj|Development Development|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Development of hapten-induced IL-4-producing CD4 + T lymphocytes requires early IL-4 production by alphabeta T lymphocytes carrying invariant V -LRB- alpha -RRB- 14 TCR alpha chains .
9637480	0	IL-4	93,97	CD4	79,82	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	have|nsubj|START_ENTITY involved|parataxis|have involved|nmod|cells cells|compound|END_ENTITY	Factors involved in the differentiation of TGF-beta-producing cells from naive CD4 + T cells : IL-4 and IFN-gamma have opposing effects , while TGF-beta positively regulates its own production .
9784657	0	IL-4	33,37	CD4	60,63	IL-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nmod|cells cells|compound|END_ENTITY	Exogenous interleukin-3 enhances IL-4 production by splenic CD4 + cells during the early stages of a Trichinella_spiralis_infection .
9820484	0	IL-4	152,156	CD4	100,103	IL-4	CD4	287287(Tax:10116)	24932(Tax:10116)	Gene	Gene	dependent|nmod|START_ENTITY cells|ccomp|dependent cells|compound|END_ENTITY	Anti-CD4 monoclonal antibody-induced tolerance to MHC-incompatible cardiac allografts maintained by CD4 + suppressor T cells that are not dependent upon IL-4 .
9278293	0	IL-4	135,139	CD40	98,102	IL-4	CD40	3565	958	Gene	Gene	ligation|nmod|START_ENTITY ligation|compound|END_ENTITY	Memory , but not naive , peripheral blood B lymphocytes differentiate into Ig-secreting cells after CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2 , IL-10 , and IL-3 .
1379131	0	IL-4	0,4	CD5	46,49	IL-4	CD5	3565	921	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	IL-4 down-regulates the surface expression of CD5 on B cells and inhibits spontaneous immunoglobulin and IgM-rheumatoid factor production in patients with rheumatoid_arthritis .
10224467	0	IL-4	0,4	CD8	20,23	IL-4	CD8	3565	925	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-4 inhibits human CD8 T cell expression of the common IL-2 receptor gamma chain .
10329842	0	IL-4	14,18	CD8	58,61	IL-4	CD8	3565	925	Gene	Gene	Production|nmod|START_ENTITY ligand|nsubj|Production ligand|nmod|cells cells|compound|END_ENTITY	Production of IL-4 and expression of CD40 ligand by human CD8 T cells .
10725381	0	IL-4	63,67	CD8	30,33	IL-4	CD8	3565	925	Gene	Gene	exposure|compound|START_ENTITY +|nmod|exposure +|nsubj|induction induction|nmod|END_ENTITY	Potent induction of long-term CD8 + T cell memory by short-term IL-4 exposure during T cell receptor stimulation .
11914057	0	IL-4	35,39	CD8	60,63	IL-4	CD8	3565	925	Gene	Gene	production|compound|START_ENTITY production|nmod|T T|compound|END_ENTITY	Decreased IFN - _ gamma and increased IL-4 production by human CD8 -LRB- + -RRB- T cells in response to Mycobacterium_tuberculosis in tuberculosis patients .
11985521	0	IL-4	38,42	CD8	146,149	IL-4	CD8	3565	925	Gene	Gene	and_interleukin|appos|START_ENTITY effects|dep|and_interleukin effects|dep|role role|nmod|cells cells|nummod|+ +|compound|END_ENTITY	The effects of CD40 - _ and_interleukin -LRB- IL-4 -RRB- - activated CD23 + cells on the production of IL-10 by mononuclear cells in Graves ' _ disease : the role of CD8 + cells .
12220104	0	IL-4	122,126	CD8	30,33	IL-4	CD8	3565	925	Gene	Gene	production|nmod|START_ENTITY cells|dep|production T|dobj|cells T|nsubj|Characterization Characterization|nmod|CD4 CD4|dep|END_ENTITY	Characterization of CD3 + CD4 - CD8 - -LRB- double negative -RRB- T cells in patients with systemic_lupus_erythematosus : production of IL-4 .
16001979	0	IL-4	0,4	CD8	62,65	IL-4	CD8	3565	925	Gene	Gene	increases|compound|START_ENTITY cytokine|nsubj|increases cytokine|nmod|cells cells|compound|END_ENTITY	IL-4 increases type 2 , but not type 1 , cytokine production in CD8 + T cells from mild atopic_asthmatics .
16914507	0	IL-4	112,116	CD8	74,77	IL-4	CD8	3565	925	Gene	Gene	dependent|nmod|START_ENTITY manner|amod|dependent enhanced|nmod|manner enhanced|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	CD1d-restricted NKT cell activation enhanced homeostatic proliferation of CD8 + T cells in a manner dependent on IL-4 .
17084909	0	IL-4	60,64	CD8	34,37	IL-4	CD8	3565	925	Gene	Gene	production|compound|START_ENTITY reduced|nsubjpass|production increased|ccomp|reduced increased|nsubj|END_ENTITY	Glatiramer_acetate-specific human CD8 -LRB- + -RRB- T cells : increased IL-4 production in multiple_sclerosis is reduced by glatiramer_acetate treatment .
17200144	0	IL-4	0,4	CD8	64,67	IL-4	CD8	3565	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|intracellular intracellular|acl|signaling signaling|dobj|cascade cascade|nmod|cells cells|compound|END_ENTITY	IL-4 induces a wide-spectrum intracellular signaling cascade in CD8 + T cells .
18054415	0	IL-4	97,101	CD8	105,108	IL-4	CD8	3565	925	Gene	Gene	expression|nmod|START_ENTITY reduces|dobj|expression reduces|nmod|cells cells|compound|END_ENTITY	Allergen immunotherapy in intermittent_allergic_rhinitis reduces the intracellular expression of IL-4 by CD8 + T cells .
18390584	0	IL-4	10,14	CD8	16,19	IL-4	CD8	3565	925	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|nummod|END_ENTITY	Increased IL-4 + CD8 + T cells in peripheral blood and autoreactive CD8 + T cell lines of patients with inflammatory_arthritis .
1911543	0	IL-4	86,90	CD8	24,27	IL-4	CD8	3565	925	Gene	Gene	cultured|nmod|START_ENTITY clones|acl|cultured expressed|dobj|clones expressed|nsubj|analysis analysis|nmod|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
1911543	0	IL-4	86,90	CD8	53,56	IL-4	CD8	3565	925	Gene	Gene	cultured|nmod|START_ENTITY clones|acl|cultured expressed|dobj|clones expressed|nmod|T T|compound|END_ENTITY	Comparative analysis of CD8 expressed on mature CD4 + CD8 + T cell clones cultured with IL-4 and that on CD8 + T cell clones : implication for functional significance of CD8_beta .
19582753	0	IL-4	43,47	CD8	80,83	IL-4	CD8	3565	925	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|modulate modulate|dobj|CTL CTL|compound|END_ENTITY	Immunisation route-dependent expression of IL-4 / IL-13 can modulate HIV-specific CD8 -LRB- + -RRB- CTL avidity .
2105169	0	IL-4	51,55	CD8	26,29	IL-4	CD4	3565	920	Gene	Gene	cloned|nmod|START_ENTITY cloned|nsubj|analysis analysis|nmod|cells cells|compound|END_ENTITY	Frequency analysis of CD4 + CD8 + T cells cloned with IL-4 .
25493691	0	IL-4	62,66	CD8	34,37	IL-4	CD8	3565	925	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|Expression Expression|nmod|Cells Cells|compound|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
7917114	0	IL-4	15,19	CD8	43,46	IL-4	CD8	3565	925	Gene	Gene	IL-10|appos|START_ENTITY IL-10|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
8906216	0	IL-4	0,4	CD8	26,29	IL-4	CD8	3565	925	Gene	Gene	differentiates|compound|START_ENTITY naive|nsubj|differentiates naive|dobj|cells cells|nummod|END_ENTITY	IL-4 differentiates naive CD8 + T cells to a `` Th2-like '' phenotype : a link between viral_infections and bronchial_asthma .
9074413	0	IL-4	126,130	CD8	156,159	IL-4	CD8	3565	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Analysis of blood T-cell cytokine expression in B-chronic_lymphocytic_leukaemia : evidence for increased levels of cytoplasmic IL-4 in resting and activated CD8 T cells .
16574063	0	IL-4	0,4	COX-2	15,20	IL-4	COX-2	3565	4513	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	IL-4 regulates COX-2 and PGE2 production in human non-small_cell_lung_cancer .
19718656	0	IL-4	42,46	CREB	55,59	IL-4	CREB	3565	1385	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of MUC5AC gene expression by IL-4 through CREB in human airway epithelial cells .
17392576	0	IL-4	170,174	CXCL8	188,193	IL-4	CXCL8	3565	3576	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
9574513	0	IL-4	0,4	CXCR4	51,56	IL-4	CXCR4	3565	7852	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IL-4 induces functional cell-surface expression of CXCR4 on human T cells .
26329514	0	IL-4	6,10	CXCR5	13,18	IL-4	CXCR5	3565	643	Gene	Gene	CD4|amod|START_ENTITY CD4|compound|END_ENTITY	Nasal IL-4 -LRB- + -RRB- CXCR5 -LRB- + -RRB- CD4 -LRB- + -RRB- T follicular helper cell counts correlate with local IgE production in eosinophilic_nasal_polyps .
21806999	0	IL-4	37,41	EL-4	65,69	IL-4	EL-4	16189(Tax:10090)	111979(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction .
11709700	0	IL-4	48,52	ERK	109,112	IL-4	ERK	3565	5594	Gene	Gene	alpha2-chain|nmod|START_ENTITY receptor|amod|alpha2-chain Induction|nmod|receptor Induction|dep|involvement involvement|nmod|pathways pathways|compound|END_ENTITY	Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes : involvement of STAT6 , ERK and p38 MAPK pathways .
15843535	0	IL-4	34,38	ERK	84,87	IL-4	ERK	3565	5594	Gene	Gene	creates|nsubj|START_ENTITY creates|dobj|pathway pathway|nmod|activation activation|compound|END_ENTITY	B cell receptor -LRB- BCR -RRB- cross-talk : IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent .
19065352	0	IL-4	137,141	ERK	61,64	IL-4	ERK	3565	5594	Gene	Gene	stimulated|nmod|START_ENTITY effect|acl|stimulated effect|nmod|extracellular_signal-regulated_kinases extracellular_signal-regulated_kinases|appos|END_ENTITY	Regulatory effect of extracellular_signal-regulated_kinases -LRB- ERK -RRB- on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13 .
18682601	0	IL-4	0,4	Erk	48,51	IL-4	Erk	3565	5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	IL-4 protein expression and basal activation of Erk in vivo in follicular_lymphoma .
9862725	0	IL-4	0,4	Fc_epsilonRI	30,42	IL-4	Fc epsilonRI	16189(Tax:10090)	14127(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-4 inhibits mouse mast cell Fc_epsilonRI expression through a STAT6-dependent mechanism .
10623799	0	IL-4	20,24	Fc_epsilon_RI	54,67	IL-4	Fc epsilon RI	3565	2205	Gene	Gene	release|compound|START_ENTITY release|nmod|cells cells|compound|END_ENTITY	HIV-1 gp120 induces IL-4 and IL-13 release from human Fc_epsilon_RI + cells through interaction with the VH3 region of IgE .
12574351	0	IL-4	46,50	Fc_epsilon_RI	82,95	IL-4	Fc epsilon RI	3565	2205	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human Fc_epsilon_RI + cells through interaction with the kappa light chains of IgE .
8921414	0	IL-4	83,87	Fc_epsilon_RI	45,58	IL-4	Fc epsilon RI	3565	2205	Gene	Gene	cells|nmod|START_ENTITY Induction|nmod|cells Induction|appos|END_ENTITY	Induction of the high-affinity IgE receptor -LRB- Fc_epsilon_RI -RRB- on human mast cells by IL-4 .
9820545	0	IL-4	44,48	Fc_epsilon_RI	70,83	IL-4	Fc epsilon RI	3565	2205	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Endogenous superallergen protein Fv induces IL-4 secretion from human Fc_epsilon_RI + cells through interaction with the VH3 region of IgE .
8977198	0	IL-4	48,52	Fc_epsilon_RII	96,110	IL-4	Fc epsilon RII	16189(Tax:10090)	14128(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc_epsilon_RII -LRB- CD23 -RRB- : comparison with the germline epsilon promoter .
19098920	0	IL-4	101,105	Fc_receptor_gamma-chain	0,23	IL-4	Fc receptor gamma-chain	3565	2207	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|END_ENTITY	Fc_receptor_gamma-chain , a constitutive component of the IL-3 receptor , is required for IL-3-induced IL-4 production in basophils .
14609572	0	IL-4	0,4	FcgammaRIII	26,37	IL-4	FcgammaRIII	16189(Tax:10090)	14131(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	IL-4 selectively enhances FcgammaRIII expression and signaling on mouse mast cells .
17675505	0	IL-4	69,73	Foxp3	22,27	IL-4	Foxp3	16189(Tax:10090)	20371(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY reveal|nsubj|mice reveal|nmod|cells cells|compound|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
8554685	0	IL-4	23,27	G-CSF	41,46	IL-4	G-CSF	3565	1440	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
10940870	0	IL-4	78,82	GM-CSF	53,59	IL-4	GM-CSF	16189(Tax:10090)	12981(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY generated|nmod|absence generated|nmod|doses doses|nmod|END_ENTITY	Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo .
15213252	0	IL-4	0,4	GM-CSF	38,44	IL-4	GM-CSF	3565	1437	Gene	Gene	transforms|nsubj|START_ENTITY transforms|advmod|alone alone|nmod|involvement involvement|nmod|END_ENTITY	IL-4 alone without the involvement of GM-CSF transforms human peripheral blood monocytes to a CD1a -LRB- dim -RRB- , CD83 -LRB- + -RRB- myeloid dendritic cell subset .
15703830	0	IL-4	0,4	GM-CSF	86,92	IL-4	GM-CSF	3565	1437	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|survival survival|nmod|monocytes monocytes|acl|supported supported|nmod|END_ENTITY	IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF .
15907205	0	IL-4	116,120	GM-CSF	139,145	IL-4	GM-CSF	3565	1437	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Research upregulation of CD23 -LRB- FcepsilonRII -RRB- expression in human airway smooth muscle cells -LRB- huASMC -RRB- in response to IL-4 , GM-CSF , and IL-4 / GM-CSF .
19651524	0	IL-4	13,17	GM-CSF	88,94	IL-4	GM-CSF	16189(Tax:10090)	12981(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY release|nsubj|Induction release|nmod|END_ENTITY	Induction of IL-4 release and upregulated expression of protease_activated_receptors by GM-CSF in P815 cells .
8502331	0	IL-4	196,200	GM-CSF	202,208	IL-4	GM-CSF	3565	1437	Gene	Gene	IL-3|dep|START_ENTITY IL-3|dep|END_ENTITY	New predictive protocol for therapeutic treatment of renal_and_nonrenal_anemias with recombinant human erythropoietin with a simple immunoenzymatic dosage of serum burst-promoting activity -LRB- IL-3 , IL-4 , GM-CSF -RRB-
8554685	0	IL-4	23,27	GM-CSF	48,54	IL-4	GM-CSF	3565	1437	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
9050748	0	IL-4	0,4	GM-CSF	129,135	IL-4	GM-CSF	3565	1437	Gene	Gene	proliferation|compound|START_ENTITY regulated|nsubjpass|proliferation regulated|nmod|production production|nmod|END_ENTITY	IL-4 and TNF-alpha-mediated proliferation of the human megakaryocytic line M-O7E is regulated by induced autocrine production of GM-CSF .
15993493	0	IL-4	48,52	GPR84	32,37	IL-4	GPR84	16189(Tax:10090)	80910(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The G-protein coupled receptor , GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking .
12049724	0	IL-4	39,43	Growth_factor_independent-1	0,27	IL-4	Growth factor independent-1	3565	2672	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Growth_factor_independent-1 induced by IL-4 regulates Th2 cell proliferation .
10409231	0	IL-4	0,4	ICAM-1	13,19	IL-4	ICAM-1	3565	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-4 induces ICAM-1 expression in human bronchial epithelial cells and potentiates TNF-alpha .
1347050	0	IL-4	76,80	ICAM-1	14,20	IL-4	ICAM-1	3565	3383	Gene	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4 .
1349767	0	IL-4	0,4	ICAM-1	45,51	IL-4	ICAM-1	3565	3383	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	IL-4 decreases IFN-gamma-induced endothelial ICAM-1 expression by a transcriptional mechanism .
1362565	0	IL-4	97,101	ICAM-1	176,182	IL-4	ICAM-1	16189(Tax:10090)	15894(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production regulated|nmod|interactions interactions|nmod|END_ENTITY	Antigen presentation by murine splenic , but not hepatic , antigen-presenting_cells to induce IL-2 / IL-4 production from immune T cells is regulated by interactions between LFA-1 / ICAM-1 .
17661345	0	IL-4	85,89	IDO	18,21	IL-4	IDO	3565	3620	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	IFN-gamma-induced IDO and WRS expression in microglia is differentially regulated by IL-4 .
8569177	0	IL-4	112,116	IFN-alpha	131,140	IL-4	IFN-alpha	16189(Tax:10090)	111654(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
11080475	0	IL-4	66,70	IFN-beta	43,51	IL-4	IFN-beta	16189(Tax:10090)	15977(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of the constitutive and induced IFN-beta production by IL-4 and IL-10 in murine peritoneal macrophages .
10454344	0	IL-4	176,180	IFN-gamma	146,155	IL-4	IFN-gamma	280824(Tax:9913)	281237(Tax:9913)	Gene	Gene	has|nsubj|START_ENTITY enhances|advcl|has enhances|dobj|production production|amod|END_ENTITY	Comparative effects of interleukin-12 and interleukin-4 on cytokine responses by antigen-stimulated memory CD4 + T cells of cattle : IL-12 enhances IFN-gamma production , whereas IL-4 has marginal effects on cytokine expression .
10482358	0	IL-4	161,165	IFN-gamma	71,80	IL-4	IFN-gamma	3565	3458	Gene	Gene	cultured|nmod|START_ENTITY cells|acl|cultured transcription|nmod|cells essential|nmod|transcription essential|nsubj|Hypomethylation Hypomethylation|nmod|regions regions|nmod|gene gene|amod|END_ENTITY	Hypomethylation of the proximal and intronic regulatory regions of the IFN-gamma gene is not essential for its transcription by naive CD4 + T cells cultured with IL-4 .
10604994	0	IL-4	23,27	IFN-gamma	57,66	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells .
10605032	0	IL-4	0,4	IFN-gamma	114,123	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	antagonize|nsubj|START_ENTITY antagonize|nmod|role role|nmod|END_ENTITY	IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia_virus infection with a limited role of IFN-gamma and nitric_oxide synthetase 2 .
10706694	0	IL-4	24,28	IFN-gamma	98,107	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	IL-12|nmod|START_ENTITY differentiation|amod|IL-12 Dominance|nmod|differentiation leads|nsubj|Dominance leads|xcomp|default default|dobj|production production|nmod|END_ENTITY	Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma : failure to down-regulate IL-12 receptor beta 2-chain expression .
11033016	0	IL-4	53,57	IFN-gamma	42,51	IL-4	IFN-gamma	287287(Tax:10116)	25712(Tax:10116)	Gene	Gene	T-cells|nsubj|START_ENTITY T-cells|nsubj|analysis analysis|nmod|END_ENTITY	Flow cytometric analysis of intracellular IFN-gamma , IL-4 and IL-10 in CD3 -LRB- + -RRB- 4 -LRB- + -RRB- T-cells from rat spleen .
11067899	0	IL-4	77,81	IFN-gamma	0,9	IL-4	IFN-gamma	3565	3458	Gene	Gene	expression|compound|START_ENTITY down-regulate|dobj|expression down-regulate|nsubj|END_ENTITY	IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4-induced IL-4 receptor gene expression .
11160342	0	IL-4	0,4	IFN-gamma	49,58	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|eosinophilia eosinophilia|advcl|suppressing suppressing|dobj|production production|amod|END_ENTITY	IL-4 promotes airway eosinophilia by suppressing IFN-gamma production : defining a novel role for IFN-gamma in the regulation of allergic_airway_inflammation .
11160342	0	IL-4	0,4	IFN-gamma	97,106	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|parataxis|defining defining|dobj|role role|nmod|END_ENTITY	IL-4 promotes airway eosinophilia by suppressing IFN-gamma production : defining a novel role for IFN-gamma in the regulation of allergic_airway_inflammation .
11180096	0	IL-4	0,4	IFN-gamma	163,172	IL-4	IFN-gamma	287287(Tax:10116)	3458	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|fibroblasts fibroblasts|acl|activated activated|nmod|END_ENTITY	IL-4 and IL-13 regulate the induction of indoleamine 2,3-dioxygenase activity and the control of Toxoplasma_gondii replication in human fibroblasts activated with IFN-gamma .
11359851	0	IL-4	129,133	IFN-gamma	134,143	IL-4	IFN-gamma	3565	3458	Gene	Gene	cells|nmod|START_ENTITY subset|nmod|cells subset|dep|ratios ratios|amod|END_ENTITY	Chemokine receptor CCR4 on CD4 + T cells in juvenile rheumatoid_arthritis synovial fluid defines a subset of cells with increased IL-4 : IFN-gamma mRNA ratios .
11500833	0	IL-4	60,64	IFN-gamma	134,143	IL-4	IFN-gamma	3565	3458	Gene	Gene	synthesis|compound|START_ENTITY triggers|dobj|synthesis signal|acl:relcl|triggers induces|dobj|signal induces|ccomp|induces induces|dobj|kinases kinases|acl:relcl|control control|dobj|production production|amod|END_ENTITY	Weak TCR stimulation induces a calcium signal that triggers IL-4 synthesis , stronger TCR stimulation induces MAP kinases that control IFN-gamma production .
11777537	0	IL-4	0,4	IFN-gamma	29,38	IL-4	IFN-gamma	280824(Tax:9913)	281237(Tax:9913)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	IL-4 and IL-10 inhibition of IFN-gamma - and TNF-alpha-dependent nitric_oxide production from bovine mononuclear phagocytes exposed to Babesia_bovis merozoites .
11877032	0	IL-4	43,47	IFN-gamma	49,58	IL-4	IFN-gamma	3565	3458	Gene	Gene	expressions|nmod|START_ENTITY -LSB-|nmod|expressions -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- A comparative study on the expressions of IL-4 , IFN-gamma and TNF-alpha in BMMNC of acute and chronic aplastic_anemia patients -RSB- .
11971011	0	IL-4	6,10	IFN-gamma	138,147	IL-4	IFN-gamma	3565	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY T|nsubj|production T|dobj|cells cells|nmod|mice mice|acl|treated treated|nmod|antibodies antibodies|amod|END_ENTITY	Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4 -LRB- + -RRB- T cells in resistant mice treated once with anti-IL-12 or - IFN-gamma antibodies at the onset of infection with Leishmania_major instructs Th2 cell development , resulting in nonhealing lesions .
12055229	0	IL-4	124,128	IFN-gamma	42,51	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY preventing|dobj|effects regulates|nmod|preventing regulates|advmod|END_ENTITY	Role of IFN-gamma in Th1 differentiation : IFN-gamma regulates IL-18R_alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression .
12055229	0	IL-4	124,128	IFN-gamma	8,17	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY preventing|dobj|effects regulates|nmod|preventing Role|parataxis|regulates Role|nmod|END_ENTITY	Role of IFN-gamma in Th1 differentiation : IFN-gamma regulates IL-18R_alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression .
12405160	0	IL-4	67,71	IFN-gamma	72,81	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	lymphocyte|nmod|START_ENTITY NK_1|dep|lymphocyte NK_1|parataxis|paradigm paradigm|amod|END_ENTITY	NK_1 .1 + T cell : a two-faced lymphocyte in immune modulation of the IL-4 / IFN-gamma paradigm .
12479817	0	IL-4	20,24	IFN-gamma	0,9	IL-4	IFN-gamma	3565	3458	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 .
12637316	0	IL-4	0,4	IFN-gamma	59,68	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|IL-2 IL-2|dep|expression expression|amod|END_ENTITY	IL-4 synergistically enhances both IL-2 - _ and_IL-12-induced IFN-gamma expression in murine NK cells .
12702146	0	IL-4	60,64	IFN-gamma	36,45	IL-4	IFN-gamma	3565	3458	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Ultraviolet-B irradiation decreases IFN-gamma and increases IL-4 expression in psoriatic lesional skin in situ and in cultured dermal T cells derived from these lesions .
12954239	0	IL-4	94,98	IFN-gamma	60,69	IL-4	IFN-gamma	280824(Tax:9913)	281237(Tax:9913)	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|IL-1_alpha IL-1_alpha|dep|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
15059068	0	IL-4	14,18	IFN-gamma	19,28	IL-4	IFN-gamma	3565	3458	Gene	Gene	START_ENTITY|parataxis|producing producing|nsubj|END_ENTITY	Intracellular IL-4 / IFN-gamma producing peripheral T lymphocyte subsets in B cell non-Hodgkin 's _ lymphoma patients .
1531844	0	IL-4	0,4	IFN-gamma	52,61	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	suppresses|compound|START_ENTITY cytokine|nsubj|suppresses cytokine|dobj|expression expression|acl|induced induced|nmod|IL-2 IL-2|compound|END_ENTITY	IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages .
15661890	0	IL-4	80,84	IFN-gamma	0,9	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY inhibiting|nmod|receptor STAT6|advcl|inhibiting STAT6|nsubj|suppresses suppresses|amod|END_ENTITY	IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor .
16237058	0	IL-4	59,63	IFN-gamma	44,53	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY produce|nmod|stimulation produce|dobj|END_ENTITY	Murine plasmacytoid dendritic cells produce IFN-gamma upon IL-4 stimulation .
1627494	0	IL-4	24,28	IFN-gamma	55,64	IL-4	IFN-gamma	3565	3458	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|synthesis synthesis|amod|END_ENTITY	Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity .
16513426	0	IL-4	52,56	IFN-gamma	30,39	IL-4	IFN-gamma	3565	3458	Gene	Gene	IL-5|appos|START_ENTITY IL-5|appos|END_ENTITY	Evaluation of cytokines -LRB- MIG , IFN-gamma , TNF-alpha , IL-4 , IL-5 , and IL-10 -RRB- during the different evolutive phases of chagasic esophagopathy .
16621996	0	IL-4	0,4	IFN-gamma	35,44	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|production production|nmod|END_ENTITY	IL-4 induces in vivo production of IFN-gamma by NK and NKT cells .
17075267	0	IL-4	55,59	IFN-gamma	80,89	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|nmod|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
1904904	0	IL-4	19,23	IFN-gamma	0,9	IL-4	IFN-gamma	3565	3458	Gene	Gene	inhibition|compound|START_ENTITY reverses|dobj|inhibition reverses|nsubj|END_ENTITY	IFN-gamma reverses IL-4 inhibition of fetal thymus growth in organ culture .
19079171	0	IL-4	78,82	IFN-gamma	123,132	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Persistence of Entamoeba_histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-gamma .
2115545	0	IL-4	28,32	IFN-gamma	124,133	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression marrow-derived|nsubj|Induction marrow-derived|nmod|END_ENTITY	Induction and regulation of IL-4 receptor expression on murine macrophage cell lines and bone marrow-derived macrophages by IFN-gamma .
2118480	0	IL-4	46,50	IFN-gamma	97,106	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	Priming|nmod|START_ENTITY enhancement|dep|Priming enhancement|nmod|TNF-alpha TNF-alpha|acl|inhibition inhibition|nmod|END_ENTITY	Priming the macrophage respiratory burst with IL-4 : enhancement with TNF-alpha but inhibition by IFN-gamma .
2136895	0	IL-4	0,4	IFN-gamma	31,40	IL-4	IFN-gamma	3565	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|END_ENTITY	IL-4 inhibits the synthesis of IFN-gamma and induces the synthesis of IgE in human mixed lymphocyte cultures .
23259293	0	IL-4	22,26	IFN-gamma	28,37	IL-4	IFN-gamma	3565	3458	Gene	Gene	START_ENTITY|appos|methylation methylation|amod|END_ENTITY	-LSB- Comparative study of IL-4 , IFN-gamma gene methylation for the epigenetics of allergic_rhinitis in Xinjiang Uygur , Han people -RSB- .
24015634	0	IL-4	17,21	IFN-gamma	23,32	IL-4	IFN-gamma	3565	3458	Gene	Gene	START_ENTITY|appos|IL-32 IL-32|compound|END_ENTITY	-LSB- Levels of serum IL-4 , IFN-gamma , IL-32 in children with juvenile-onset recurrent respiratory_papillomatosis -RSB- .
2509562	0	IL-4	0,4	IFN-gamma	99,108	IL-4	IFN-gamma	3565	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|monocytes monocytes|acl|mediated mediated|nmod|END_ENTITY	IL-4 inhibits H2O2 production and antileishmanial capacity of human cultured monocytes mediated by IFN-gamma .
25272942	0	IL-4	32,36	IFN-gamma	15,24	IL-4	IFN-gamma	3565	3458	Gene	Gene	IL-17|compound|START_ENTITY END_ENTITY|dep|IL-17	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
2844892	0	IL-4	159,163	IFN-gamma	0,9	IL-4	IFN-gamma	3565	3458	Gene	Gene	binding|nmod|START_ENTITY altering|dobj|binding lymphocytes|advcl|altering inhibit|ccomp|lymphocytes inhibit|nsubj|END_ENTITY	IFN-gamma and prostaglandin_E2 inhibit IL-4-induced expression of Fc epsilon R2/CD23 on B lymphocytes through different mechanisms without altering binding of IL-4 to its receptor .
7530038	0	IL-4	32,36	IFN-gamma	37,46	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	establishment|nmod|START_ENTITY establishment|dep|profile profile|amod|END_ENTITY	Rapid establishment of a stable IL-4 / IFN-gamma production profile in the antigen-specific CD4 + T cell response to protein immunization .
7542576	0	IL-4	96,100	IFN-gamma	84,93	IL-4	IFN-gamma	3565	3458	Gene	Gene	factor-beta|compound|START_ENTITY present|nsubj|factor-beta present|advcl|expressing expressing|dobj|interferon-gamma interferon-gamma|appos|END_ENTITY	High numbers of autoantigen-reactive mononuclear cells expressing interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- are present in cord blood .
7722306	0	IL-4	0,4	IFN-gamma	63,72	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|factor factor|acl:relcl|binds binds|dobj|END_ENTITY	IL-4 activates a latent DNA-binding factor that binds a shared IFN-gamma and IL-4 response element present in the germ-line gamma 1 Ig promoter .
7751657	0	IL-4	27,31	IFN-gamma	49,58	IL-4	IFN-gamma	3565	3458	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|response response|amod|END_ENTITY	Down-regulating effects of IL-4 and IL-10 on the IFN-gamma response in atopic_dermatitis .
7774059	0	IL-4	16,20	IFN-gamma	43,52	IL-4	IFN-gamma	3565	3458	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Increased IL-2 , IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- in steroid-sensitive nephrotic_syndrome .
7902377	1	IL-4	111,115	IFN-gamma	134,143	IL-4	IFN-gamma	3565	3458	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison with IL-4 and modulation by IFN-gamma or IL-10 .
7994903	0	IL-4	55,59	IFN-gamma	43,52	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Cross-regulatory role of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and IL-10 in schistosome egg granuloma formation : in vivo regulation of Th activity and inflammation .
8004818	0	IL-4	69,73	IFN-gamma	93,102	IL-4	IFN-gamma	3565	3458	Gene	Gene	START_ENTITY|appos|interferon-gamma interferon-gamma|appos|END_ENTITY	Growth and major histocompatibility antigen expression regulation by IL-4 , interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- on human renal_cell_carcinoma .
8015314	0	IL-4	125,129	IFN-gamma	90,99	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8565269	0	IL-4	48,52	IFN-gamma	95,104	IL-4	IFN-gamma	3565	3458	Gene	Gene	mRNA|nmod|START_ENTITY expression|nmod|mRNA expression|appos|END_ENTITY	Differential spontaneous expression of mRNA for IL-4 , IL-10 , IL-13 , IL-2 and interferon-gamma -LRB- IFN-gamma -RRB- in peripheral blood mononuclear cells -LRB- PBMC -RRB- from atopic patients .
8621932	0	IL-4	19,23	IFN-gamma	45,54	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation by IL-4 and up-regulation by IFN-gamma of mast cell induction from mouse spleen cells .
8805678	0	IL-4	145,149	IFN-gamma	106,115	IL-4	IFN-gamma	3565	3458	Gene	Gene	production|compound|START_ENTITY presence|nmod|production END_ENTITY|nmod|presence	Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals : decreased IFN-gamma in the presence of preserved IL-4 production .
8805678	0	IL-4	24,28	IFN-gamma	106,115	IL-4	IFN-gamma	3565	3458	Gene	Gene	production|compound|START_ENTITY analysis|nmod|production analysis|dep|END_ENTITY	Single cell analysis of IL-4 and IFN-gamma production by T cells from HIV-infected individuals : decreased IFN-gamma in the presence of preserved IL-4 production .
8921430	0	IL-4	67,71	IFN-gamma	79,88	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Differential production of IL-12 in BALB/c and DBA/2 mice controls IL-4 versus IFN-gamma synthesis in primed CD4 lymphocytes .
8943375	0	IL-4	0,4	IFN-gamma	94,103	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	neutralization|compound|START_ENTITY ameliorate|nsubj|neutralization ameliorate|nmod|pathogen pathogen|nmod|mice mice|amod|END_ENTITY	IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice .
9182905	0	IL-4	37,41	IFN-gamma	64,73	IL-4	IFN-gamma	3565	3458	Gene	Gene	histamine|nmod|START_ENTITY modulation|nmod|histamine modulation|appos|END_ENTITY	Different modulation by histamine of IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- release according to the phenotype of human Th0 , Th1 and Th2 clones .
9328118	0	IL-4	24,28	IFN-gamma	51,60	IL-4	IFN-gamma	280824(Tax:9913)	281237(Tax:9913)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Antagonistic effects of IL-4 and interferon-gamma -LRB- IFN-gamma -RRB- on inducible nitric_oxide synthase expression in bovine macrophages exposed to gram-positive bacteria .
9394788	0	IL-4	151,155	IFN-gamma	123,132	IL-4	IFN-gamma	3565	3458	Gene	Gene	secretion|compound|START_ENTITY predominates|nmod|secretion predominates|amod|END_ENTITY	Compartmentalization of antigen specific cytokine responses to the central nervous system in CNS borreliosis : secretion of IFN-gamma predominates over IL-4 secretion in response to outer surface proteins of Lyme_disease Borrelia spirochetes .
9550426	0	IL-4	93,97	IFN-gamma	0,9	IL-4	IFN-gamma	3565	3458	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	IFN-gamma and IL-10 inhibit induction of IL-1 receptor type I and type II gene expression by IL-4 and IL-13 in human monocytes .
9619449	0	IL-4	117,121	IFN-gamma	102,111	IL-4	IFN-gamma	3565	3458	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|nmod|responses	Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses .
9683262	0	IL-4	0,4	IFN-gamma	81,90	IL-4	IFN-gamma	3565	3458	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|hypomethylation hypomethylation|nmod|region region|nmod|gene gene|amod|END_ENTITY	IL-4 and prostaglandin_E2 inhibit hypomethylation of the 5 ' regulatory region of IFN-gamma gene during differentiation of naive CD4 + T cells .
9712058	0	IL-4	0,4	IFN-gamma	109,118	IL-4	IFN-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|parataxis|lymphocytes lymphocytes|nsubj|analysis analysis|nmod|+ +|amod|END_ENTITY	IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium_parvum infection : analysis of CD4 + alpha beta + IFN-gamma + and CD4 + alpha beta + IL-4 + lymphocytes in gut-associated lymphoid tissue during resolution of infection .
20233967	0	IL-4	0,4	IFN-lambda1	14,25	IL-4	IFN-lambda1	3565	282618	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	IL-4 enhances IFN-lambda1 -LRB- IL-29 -RRB- production by plasmacytoid DCs via monocyte secretion of IL-1Ra .
21161049	0	IL-4	56,60	IFN-y	62,67	IL-4	IFN-y	3565	3458	Gene	Gene	Effect|appos|START_ENTITY END_ENTITY|nsubj|Effect	Effect of dynorphin_A -LRB- 1-17 -RRB- on proliferation and IL-2 , IL-4 , IFN-y production by peripheral blood mononuclears .
21968955	0	IL-4	30,34	IFN-y	23,28	IL-4	IFN-y	3565	3458	Gene	Gene	IL-13|compound|START_ENTITY alterations|compound|IL-13 END_ENTITY|appos|alterations	Inflammatory cytokines IFN-y , IL-4 , IL-13 and TNF-a alterations in schistosomiasis : a meta-analysis .
23980846	0	IL-4	80,84	IFN-y	59,64	IL-4	IFN-y	3565	3458	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Black currant seed oil supplementation of mothers enhances IFN-y and suppresses IL-4 production in breast milk .
25022962	0	IL-4	19,23	IFN-y	39,44	IL-4	IFN-y	3565	3458	Gene	Gene	IL-12|compound|START_ENTITY IL-12|dep|END_ENTITY	In situ cytokines -LRB- IL-4 , IL-10 , IL-12 , IFN-y -RRB- _ and_chemokines -LRB- MCP-1 , MIP-1a -RRB- gene expression in human Leishmania _ -LRB- Leishmania -RRB- _ Mexicana_infection .
25585347	0	IL-4	78,82	IFN-y	30,35	IL-4	IFN-y	3565	3458	Gene	Gene	expression|compound|START_ENTITY cells|nmod|expression activation|nmod|cells induces|dobj|activation induces|nsubj|Iopromide Iopromide|nmod|combination combination|nmod|END_ENTITY	Iopromide in combination with IFN-y induces the activation of HMC-1 cells via IL-4 and MCP-1 expression .
11198376	0	IL-4	6,10	IL-1	0,4	IL-4	IL-1	3565	3552	Gene	Gene	production|dep|START_ENTITY production|compound|END_ENTITY	IL-1 , IL-4 production and IgE levels in acute and chronic fasciolosis before and after triclabendazole treatment .
1386862	0	IL-4	0,4	IL-1	28,32	IL-4	IL-1	3565	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IL-4 reciprocally regulates IL-1 and IL-1_receptor_antagonist expression in human monocytes .
15178892	0	IL-4	36,40	IL-1	30,34	IL-4	IL-1	3565	3552	Gene	Gene	receptors|compound|START_ENTITY levels|appos|receptors levels|nmod|END_ENTITY	Altered levels of the soluble IL-1 , IL-4 and TNF receptors , as well as the IL-1_receptor_antagonist , in intermittent_allergic_rhinitis .
23608488	0	IL-4	0,4	IL-1	19,23	IL-4	IL-1	3565	3553	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|expression expression|amod|induced induced|amod|END_ENTITY	IL-4 inhibition of IL-1 induced Matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun_N-terminal_kinase -LRB- JNK -RRB- .
8332913	0	IL-4	77,81	IL-1	51,55	IL-4	IL-1	3565	3552	Gene	Gene	regulated|nmod|START_ENTITY target|acl:relcl|regulated target|nmod|END_ENTITY	Interleukin-1_type_II_receptor : a decoy target for IL-1 that is regulated by IL-4 .
9047078	0	IL-4	119,123	IL-1	14,18	IL-4	IL-1	3565	3553	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of IL-1 induced tissue factor -LRB- TF -RRB- synthesis and procoagulant_activity -LRB- PCA -RRB- in purified human monocytes by IL-4 , IL-10 and IL-13 .
9190949	0	IL-4	135,139	IL-1	50,54	IL-4	IL-1	3565	3553	Gene	Gene	effects|nmod|START_ENTITY release|dep|effects release|nmod|type type|acl:relcl|intracellular intracellular|dobj|antagonist antagonist|compound|END_ENTITY	Extracellular release of the type I intracellular IL-1 receptor antagonist from human airway epithelial cells : differential effects of IL-4 , IL-13 , IFN-gamma , and corticosteroids .
9632524	0	IL-4	0,4	IL-1	62,66	IL-4	IL-1	3565	3552	Gene	Gene	downregulate|nsubj|START_ENTITY downregulate|xcomp|rolling rolling|nmod|cells cells|amod|END_ENTITY	IL-4 and IL-13 downregulate rolling adhesion of leukocytes to IL-1 or TNF-alpha-activated endothelial cells by limiting the interval of E-selectin expression .
10433804	0	IL-4	56,60	IL-10	88,93	IL-4	IL-10	3565	3586	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|acl|upregulation upregulation|nmod|END_ENTITY	Hyaluronectin secretion by monocytes : downregulation by IL-4 and IL-13 , upregulation by IL-10 .
11529906	0	IL-4	86,90	IL-10	92,97	IL-4	IL-10	3565	3586	Gene	Gene	IFN-gamma|dep|START_ENTITY IFN-gamma|dep|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
11550960	0	IL-4	28,32	IL-10	16,21	IL-4	IL-10	3565	3586	Gene	Gene	Interleukin_10|appos|START_ENTITY Interleukin_10|appos|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- , not IL-4 or interferon-gamma production , correlates with progression of joint destruction in rheumatoid_arthritis .
11698430	0	IL-4	71,75	IL-10	0,5	IL-4	IL-10	3565	3586	Gene	Gene	suppress|nsubj|START_ENTITY induces|advcl|suppress induces|nsubj|END_ENTITY	IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-gamma suppress it .
11985521	0	IL-4	38,42	IL-10	87,92	IL-4	IL-10	3565	3586	Gene	Gene	and_interleukin|appos|START_ENTITY effects|dep|and_interleukin effects|dep|cells cells|nmod|production production|nmod|END_ENTITY	The effects of CD40 - _ and_interleukin -LRB- IL-4 -RRB- - activated CD23 + cells on the production of IL-10 by mononuclear cells in Graves ' _ disease : the role of CD8 + cells .
12371537	0	IL-4	0,4	IL-10	134,139	IL-4	IL-10	3565	3586	Gene	Gene	supplemented|nsubj|START_ENTITY supplemented|ccomp|show show|nmod|stimulation stimulation|nmod|END_ENTITY	IL-4 supplemented B-cell cultures of allergic children show reduced IgA and IgG production in response to additional stimulation with IL-10 .
14514890	0	IL-4	96,100	IL-10	28,33	IL-4	IL-10	3565	3586	Gene	Gene	costimulation|compound|START_ENTITY requires|dobj|costimulation requires|nsubj|Establishment Establishment|nmod|memory memory|nmod|expression expression|compound|END_ENTITY	Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation .
1588047	0	IL-4	22,26	IL-10	0,5	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	factor-beta|compound|START_ENTITY synergizes|nmod|factor-beta synergizes|nsubj|END_ENTITY	IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity .
16365450	0	IL-4	25,29	IL-10	32,37	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|dep|END_ENTITY	Chemotactic responses of IL-4 - , IL-10 - , and IFN-gamma-producing CD4 + T cells depend on tissue origin and microbial stimulus .
16513385	0	IL-4	62,66	IL-10	32,37	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Induction Induction|nmod|chronic_colitis chronic_colitis|nmod|mice mice|compound|END_ENTITY	Induction of chronic_colitis in IL-10 deficient mice requires IL-4 .
16517715	0	IL-4	58,62	IL-10	29,34	IL-4	IL-10	3565	3586	Gene	Gene	locus|nmod|START_ENTITY locus|nsubj|END_ENTITY	GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4 + T cells .
17021766	0	IL-4	18,22	IL-10	24,29	IL-4	IL-10	3565	3586	Gene	Gene	levels|nmod|START_ENTITY mononuclear|nmod|levels mononuclear|nsubj|mRNA mRNA|compound|TGF-beta1 TGF-beta1|compound|END_ENTITY	In vivo levels of IL-4 , IL-10 , TGF-beta1 and IFN-gamma mRNA of the peripheral blood mononuclear cells in patients with alopecia areata in comparison to those in patients with atopic_dermatitis .
17392576	0	IL-4	170,174	IL-10	202,207	IL-4	IL-10	3565	3586	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|IL-13 IL-13|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17675505	0	IL-4	69,73	IL-10	147,152	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY reveal|nsubj|mice reveal|nmod|source source|nmod|END_ENTITY	Despite increased CD4 + Foxp3 + cells within the infection site , BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania_major susceptibility .
18475727	0	IL-4	43,47	IL-10	49,54	IL-4	IL-10	3565	3586	Gene	Gene	IL-13|compound|START_ENTITY IL-13|dep|END_ENTITY	Regulation by anti-inflammatory cytokines -LRB- IL-4 , IL-10 , IL-13 , TGFbeta -RRB- of interleukin-8 production by LPS - and / or TNFalpha-activated human polymorphonuclear cells .
18775694	0	IL-4	55,59	IL-10	49,54	IL-4	IL-10	3565	3586	Gene	Gene	stem|nsubj|START_ENTITY Upregulation|parataxis|stem Upregulation|nmod|END_ENTITY	Upregulation of chemokine_receptor expression by IL-10 / IL-4 in adult neural stem cells .
20812238	0	IL-4	104,108	IL-10	76,81	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	DX5 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells modulate cytokine production by CD4 -LRB- + -RRB- T cells towards IL-10 via the production of IL-4 .
22484241	0	IL-4	33,37	IL-10	77,82	IL-4	IL-10	3565	3586	Gene	Gene	actions|nmod|START_ENTITY mediated|nsubjpass|actions mediated|nmod|END_ENTITY	The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10 , RP105 or the kinase activity of RIPK2 .
23545299	0	IL-4	60,64	IL-10	67,72	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	interleukin-4|appos|START_ENTITY induce|iobj|interleukin-4 induce|dobj|T T|compound|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
24578755	0	IL-4	27,31	IL-10	45,50	IL-4	IL-10	3565	3586	Gene	Gene	Assessment|nmod|START_ENTITY END_ENTITY|nsubj|Assessment	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
25022962	0	IL-4	19,23	IL-10	25,30	IL-4	IL-10	3565	3586	Gene	Gene	IL-12|compound|START_ENTITY IL-12|dep|END_ENTITY	In situ cytokines -LRB- IL-4 , IL-10 , IL-12 , IFN-y -RRB- _ and_chemokines -LRB- MCP-1 , MIP-1a -RRB- gene expression in human Leishmania _ -LRB- Leishmania -RRB- _ Mexicana_infection .
25267883	0	IL-4	58,62	IL-10	0,5	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY macrophages|acl|induced phenotype|nmod|macrophages enhances|dobj|phenotype enhances|nsubj|END_ENTITY	IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration .
25272942	0	IL-4	32,36	IL-10	38,43	IL-4	IL-10	3565	3586	Gene	Gene	IL-17|compound|START_ENTITY IL-17|dep|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
25942601	0	IL-4	16,20	IL-10	81,86	IL-4	IL-10	3565	3586	Gene	Gene	effect|nmod|START_ENTITY T|nsubj|effect T|parataxis|promoting promoting|nmod|production production|compound|END_ENTITY	A new effect of IL-4 on human y T cells : promoting regulatory V 1 T cells via IL-10 production and inhibiting function of V 2 T cells .
7520376	0	IL-4	141,145	IL-10	106,111	IL-4	IL-10	3565	3586	Gene	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Effect of IL-2 on immunoglobulin production by anti-CD40-activated human B cells : synergistic effect with IL-10 and antagonistic effect with IL-4 .
7665991	0	IL-4	66,70	IL-10	0,5	IL-4	IL-10	3565	3586	Gene	Gene	presence|nmod|START_ENTITY up-regulates|nmod|presence up-regulates|nsubj|END_ENTITY	IL-10 up-regulates human monocyte phagocytosis in the presence of IL-4 and IFN-gamma .
7749574	0	IL-4	111,115	IL-10	0,5	IL-4	IL-10	3565	3586	Gene	Gene	that|nmod|START_ENTITY correlates|nmod|that correlates|nsubj|secretion secretion|compound|END_ENTITY	IL-10 secretion of allergen-specific skin-derived T cells correlates positively with that of the Th2 cytokines IL-4 and IL-5 .
7954438	0	IL-4	140,144	IL-10	158,163	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8015314	0	IL-4	125,129	IL-10	130,135	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY production|dep|release production|compound|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8569177	0	IL-4	112,116	IL-10	124,129	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8660851	0	IL-4	0,4	IL-10	24,29	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|release release|compound|END_ENTITY	IL-4 and IL-13 modulate IL-10 release in endotoxin-stimulated murine peritoneal mononuclear phagocytes .
8836916	0	IL-4	26,30	IL-10	100,105	IL-4	IL-10	3565	3586	Gene	Gene	release|compound|START_ENTITY release|nmod|IL-1RA IL-1RA|dep|END_ENTITY	Dexamethasone antagonizes IL-4 and IL-10-induced release of IL-1RA by monocytes but augments IL-4 - , IL-10 - , and TGF-beta-induced suppression of TNF-alpha release .
9034992	0	IL-4	40,44	IL-10	47,52	IL-4	IL-10	3565	3586	Gene	Gene	interleukin_4|appos|START_ENTITY interleukin_4|amod|END_ENTITY	Elevated serum levels of interleukin_4 -LRB- IL-4 -RRB- , IL-10 , and IL-13 in patients with systemic_sclerosis .
9042433	0	IL-4	0,4	IL-10	21,26	IL-4	IL-10	3565	3586	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|MoAbs MoAbs|amod|END_ENTITY	IL-4 synergizes with IL-10 and anti-CD40 MoAbs to induce B-cell differentiation in patients with common variable immunodeficiency .
9042435	0	IL-4	18,22	IL-10	36,41	IL-4	IL-10	3565	3586	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Contrary roles of IL-4 and IL-12 on IL-10 production and proliferation of human tumour reactive T cells .
9286389	1	IL-4	144,148	IL-10	71,76	IL-4	IL-10	3565	3586	Gene	Gene	secrete|dobj|START_ENTITY can|advcl|secrete pretreated|ccomp|can pretreated|nsubj|END_ENTITY	IL-10 pretreated dendritic cells can prime naive CD4 + T cells to secrete IL-4 .
9310827	0	IL-4	0,4	IL-10	40,45	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	abrogates|nsubj|START_ENTITY abrogates|dobj|effect effect|nmod|END_ENTITY	IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental_allergic_encephalomyelitis in SJL mice .
9558023	0	IL-4	22,26	IL-10	0,5	IL-4	IL-10	3565	3586	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IL-10 synergizes with IL-4 and IL-13 in inhibiting lysosomal enzyme secretion by human monocytes and lamina propria mononuclear cells from patients with inflammatory_bowel_disease .
9558124	0	IL-4	38,42	IL-10	52,57	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY Requirement|nmod|production Requirement|dep|not not|dep|END_ENTITY	Requirement for in vivo production of IL-4 , but not IL-10 , in the induction of proliferative suppression by filarial parasites .
9570548	0	IL-4	38,42	IL-10	52,57	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY Requirement|nmod|production Requirement|dep|not not|dep|END_ENTITY	Requirement for in vivo production of IL-4 , but not IL-10 , in the induction of proliferative suppression by filarial parasites .
9619374	1	IL-4	163,167	IL-10	168,173	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	benefit|nmod|START_ENTITY benefit|dep|therapy therapy|compound|END_ENTITY	More therapeutic benefit with IL-4 / IL-10 combination therapy than with IL-10 treatment alone .
9619374	1	IL-4	163,167	IL-10	204,209	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	benefit|nmod|START_ENTITY benefit|dep|therapy therapy|nmod|treatment treatment|compound|END_ENTITY	More therapeutic benefit with IL-4 / IL-10 combination therapy than with IL-10 treatment alone .
9626996	0	IL-4	117,121	IL-10	152,157	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	IL-10|compound|START_ENTITY IL-4|compound|IL-10 IL-4|nmod|END_ENTITY	Gender variations in early Theiler 's _ virus induced demyelinating_disease : differential susceptibility and effects of IL-4 , IL-10 and combined IL-4 with IL-10 .
9670842	0	IL-4	36,40	IL-10	82,87	IL-4	IL-10	3565	3586	Gene	Gene	levels|compound|START_ENTITY levels|nmod|levels levels|nmod|END_ENTITY	Elevated serum levels of IFN-gamma , IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating_diseases during the acute stage .
9723687	0	IL-4	177,181	IL-10	135,140	IL-4	IL-10	3565	3586	Gene	Gene	secrete|dobj|START_ENTITY treated|xcomp|secrete treated|nmod|cells cells|compound|END_ENTITY	Induction of Th2 cell differentiation in the primary immune response : dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4 + T cells to secrete IL-4 .
9743342	0	IL-4	80,84	IL-10	119,124	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	IFN-gamma|nmod|START_ENTITY IFN-gamma|dep|induction induction|nmod|END_ENTITY	Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versus IL-4 and IL-10 : selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4 .
9886391	0	IL-4	0,4	IL-10	14,19	IL-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement .
8647228	0	IL-4	15,19	IL-11	41,46	IL-4	IL-11	16189(Tax:10090)	16156(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- in combination with IL-11 or IL-6 reverses the inhibitory effect of IL-3 on early B lymphocyte development .
10049749	0	IL-4	53,57	IL-13	58,63	IL-4	IL-13	3565	3596	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Intergenic transcription occurs throughout the human IL-4 / IL-13 gene cluster .
10335482	0	IL-4	25,29	IL-13	0,5	IL-4	IL-13	3565	3596	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	IL-13 can substitute for IL-4 in the generation of dendritic cells for the induction of cytotoxic T lymphocytes and gene therapy .
10679097	0	IL-4	95,99	IL-13	111,116	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY defines|dobj|roles defines|parataxis|agent agent|nsubj|END_ENTITY	Schistosome infection of transgenic_mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13 : IL-13 is a profibrotic agent .
10940898	0	IL-4	39,43	IL-13	61,66	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY expulsion|nmod|mice dependent|nsubj|expulsion dependent|advmod|END_ENTITY	Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent .
11058569	0	IL-4	20,24	IL-13	66,71	IL-4	IL-13	3565	3596	Gene	Gene	Characterization|nmod|START_ENTITY signals|nsubj|Characterization signals|xcomp|dependent dependent|nmod|chain chain|compound|END_ENTITY	Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1 : redundancy of requirement of tyrosine residue for STAT3 activation .
11120785	0	IL-4	42,46	IL-13	47,52	IL-4	IL-13	3565	3596	Gene	Gene	remodeling|nmod|START_ENTITY edge|dep|remodeling edge|dep|region region|compound|END_ENTITY	Cutting edge : chromatin remodeling at the IL-4 / IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster .
11160216	0	IL-4	45,49	IL-13	50,55	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	Reconstitution|nmod|START_ENTITY Reconstitution|dep|receptor receptor|compound|END_ENTITY	Reconstitution of a functional human type II IL-4 / IL-13 receptor in mouse B cells : demonstration of species specificity .
11179348	0	IL-4	167,171	IL-13	173,178	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	colonization|appos|START_ENTITY colonization|dep|receptor receptor|compound|END_ENTITY	Adoptive transfer of CD4 + T cells specific for subunit A of Helicobacter_pylori urease reduces H. _ pylori stomach colonization in mice in the absence of interleukin-4 -LRB- IL-4 -RRB- / IL-13 receptor signaling .
11591117	0	IL-4	23,27	IL-13	173,178	IL-4	IL-13	3565	3596	Gene	Gene	effect|nmod|START_ENTITY effect|dep|loss loss|nmod|receptors receptors|compound|END_ENTITY	Differential effect of IL-4 and IL-13 on CD44 expression in the Burkitt 's _ lymphoma B cell line BL30/B95 -8 and in Epstein-Barr_virus _ -LRB- EBV -RRB- transformed human B cells : loss of IL-13 receptors on Burkitt 's _ lymphoma B cells .
11709700	0	IL-4	48,52	IL-13	17,22	IL-4	IL-13	3565	3596	Gene	Gene	alpha2-chain|nmod|START_ENTITY receptor|amod|alpha2-chain receptor|compound|END_ENTITY	Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes : involvement of STAT6 , ERK and p38 MAPK pathways .
11813160	0	IL-4	100,104	IL-13	20,25	IL-4	IL-13	3565	3596	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Distinction Distinction|nmod|+ +|compound|END_ENTITY	Distinction between IL-13 + and IFN-gamma + natural killer cells and regulation of their pool size by IL-4 .
12421669	0	IL-4	43,47	IL-13	48,53	IL-4	IL-13	3565	3596	Gene	Gene	antagonists|nmod|START_ENTITY system|nmod|antagonists system|amod|END_ENTITY	Structure , binding , and antagonists in the IL-4 / IL-13 receptor system .
12789240	0	IL-4	18,22	IL-13	23,28	IL-4	IL-13	3565	3596	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|prevents prevents|nsubj|system system|compound|END_ENTITY	Inhibition of the IL-4 / IL-13 receptor system prevents allergic_sensitization without affecting established allergy in a mouse model for allergic_asthma .
14618299	0	IL-4	44,48	IL-13	70,75	IL-4	IL-13	287287(Tax:10116)	116553(Tax:10116)	Gene	Gene	interleukin-4|appos|START_ENTITY interleukin-4|appos|END_ENTITY	Glucocorticoid inhibition of interleukin-4 -LRB- IL-4 -RRB- and interleukin-13 -LRB- IL-13 -RRB- induced up-regulation of arginase in rat airway fibroblasts .
14983029	0	IL-4	50,54	IL-13	55,60	IL-4	IL-13	3565	3596	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|parataxis|cluster cluster|nsubj|gene gene|compound|END_ENTITY	Analysis of intergenic transcription in the human IL-4 / IL-13 gene cluster .
15322207	0	IL-4	98,102	IL-13	103,108	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung_fibrosis : role of IL-4 / IL-13 and mediation via STAT-6 .
16141241	0	IL-4	0,4	IL-13	28,33	IL-4	IL-13	3565	3596	Gene	Gene	effective|nsubj|START_ENTITY effective|nmod|END_ENTITY	IL-4 is more effective than IL-13 for in vitro differentiation of dendritic cells from peripheral blood mononuclear cells .
16702603	0	IL-4	33,37	IL-13	38,43	IL-4	IL-13	3565	3596	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Type 2 immunity is controlled by IL-4 / IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system .
16849611	0	IL-4	141,145	IL-13	146,151	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY expression|appos|independent expression|dep|END_ENTITY	The dermal microenvironment induces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes , independent of IL-4 / IL-13 signaling .
17070934	0	IL-4	15,19	IL-13	0,5	IL-4	IL-13	397225(Tax:9823)	396721(Tax:9823)	Gene	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	IL-13 replaces IL-4 in development of monocyte derived dendritic cells -LRB- MoDC -RRB- of swine .
17077644	0	IL-4	14,18	IL-13	19,24	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|enhance enhance|nsubj|END_ENTITY	Inhibition of IL-4 / IL-13 does not enhance the efficacy of allergen immunotherapy in murine allergic airway inflammation .
17392576	0	IL-4	170,174	IL-13	209,214	IL-4	IL-13	3565	3596	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
18996576	0	IL-4	10,14	IL-13	15,20	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Targeting IL-4 / IL-13 signaling to alleviate oral allergen-induced diarrhea .
19582753	0	IL-4	43,47	IL-13	48,53	IL-4	IL-13	3565	3596	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|modulate modulate|nsubj|END_ENTITY	Immunisation route-dependent expression of IL-4 / IL-13 can modulate HIV-specific CD8 -LRB- + -RRB- CTL avidity .
19796211	0	IL-4	42,46	IL-13	47,52	IL-4	IL-13	3565	3596	Gene	Gene	effects|nmod|START_ENTITY effects|dep|antagonist antagonist|compound|END_ENTITY	Inhaled vs subcutaneous effects of a dual IL-4 / IL-13 antagonist in a monkey model of asthma .
20500673	0	IL-4	18,22	IL-13	23,28	IL-4	IL-13	287287(Tax:10116)	116553(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Direct effects of IL-4 / IL-13 and the nematode_Nippostrongylus_brasiliensis on intestinal epithelial cells in vitro .
20729386	0	IL-4	14,18	IL-13	19,24	IL-4	IL-13	3565	3596	Gene	Gene	Expression|nmod|START_ENTITY receptors|dep|Expression receptors|compound|END_ENTITY	Expression of IL-4 / IL-13 receptors in differentiating human airway epithelial cells .
21157648	0	IL-4	19,23	IL-13	24,29	IL-4	IL-13	3565	3596	Gene	Gene	Pitrakinra|appos|START_ENTITY Pitrakinra|dep|antagonist antagonist|compound|END_ENTITY	Pitrakinra , a dual IL-4 / IL-13 antagonist for the potential treatment of asthma and eczema .
21814192	0	IL-4	12,16	IL-13	17,22	IL-4	IL-13	3565	3596	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	STAT6 links IL-4 / IL-13 stimulation with pendrin expression in asthma and chronic_obstructive_pulmonary_disease .
22019418	0	IL-4	32,36	IL-13	37,42	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	START_ENTITY|appos|has has|nsubj|END_ENTITY	Lack of signaling by IL-4 or by IL-4 / IL-13 has more attenuating effects on Leishmania amazonensis dorsal skin -- than on footpad-infected mice .
23449738	0	IL-4	3,7	IL-13	8,13	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|reduces reduces|nsubj|antagonist antagonist|compound|END_ENTITY	An IL-4 / IL-13 dual antagonist reduces lung_inflammation , airway hyperresponsiveness , and IgE production in mice .
23553437	0	IL-4	14,18	IL-13	19,24	IL-4	IL-13	3565	3596	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting the IL-4 / IL-13 signaling pathway sensitizes Hodgkin_lymphoma cells to chemotherapeutic drugs .
23582327	5	IL-4	608,612	IL-13	613,618	IL-4	IL-13	3565	3596	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	In FAPs , IL-4 / IL-13 signaling serves as a key switch to control their fate and functions .
23880771	0	IL-4	85,89	IL-13	111,116	IL-4	IL-13	3565	3596	Gene	Gene	interleukin-4|appos|START_ENTITY interleukin-4|appos|END_ENTITY	Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 -LRB- IL-4 -RRB- and interleukin-13 -LRB- IL-13 -RRB- cytokines .
25172500	0	IL-4	15,19	IL-13	20,25	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|protects protects|nsubj|END_ENTITY	T cell-derived IL-4 / IL-13 protects mice against fatal Schistosoma_mansoni_infection independently of basophils .
25472582	0	IL-4	17,21	IL-13	22,27	IL-4	IL-13	3565	3596	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|dep|genes genes|compound|END_ENTITY	Polymorphisms in IL-4 / IL-13 pathway genes and glioma risk : an updated meta-analysis .
25493691	0	IL-4	62,66	IL-13	67,72	IL-4	IL-13	3565	3596	Gene	Gene	Regulated|nmod|START_ENTITY END_ENTITY|dep|Regulated	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
26255210	0	IL-4	25,29	IL-13	30,35	IL-4	IL-13	3565	3596	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|dep|targeting	Strategies targeting the IL-4 / IL-13 axes in disease .
26781462	0	IL-4	37,41	IL-13	42,47	IL-4	IL-13	3565	3596	Gene	Gene	expression|nmod|START_ENTITY changes|nmod|expression Analysis|nmod|changes Analysis|dep|END_ENTITY	Analysis of changes in expression of IL-4 / IL-13 / STAT6 pathway and correlation with the selected clinical parameters in patients with atopic_asthma .
8605347	0	IL-4	150,154	IL-13	16,21	IL-4	IL-13	3565	3596	Gene	Gene	protein|compound|START_ENTITY inhibition|nmod|protein expression|dep|inhibition induces|dobj|expression induces|nsubj|Interleukin-13 Interleukin-13|appos|END_ENTITY	Interleukin-13 -LRB- IL-13 -RRB- induces IL-1_receptor_antagonist gene expression and protein synthesis in peripheral blood mononuclear cells : inhibition by an IL-4 mutant protein .
8609418	0	IL-4	124,128	IL-13	0,5	IL-4	IL-13	3565	3596	Gene	Gene	signaling|compound|START_ENTITY similarities|nmod|signaling lines|dep|similarities phosphorylation|nmod|lines induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon_carcinoma cell lines : similarities between IL-4 and IL-13 signaling .
9013879	0	IL-4	96,100	IL-13	101,106	IL-4	IL-13	3565	3596	Gene	Gene	START_ENTITY|dep|complex complex|dep|receptor receptor|compound|END_ENTITY	Cloning of the human IL-13R_alpha1 chain and reconstitution with the IL4R_alpha of a functional IL-4 / IL-13 receptor complex .
9099934	0	IL-4	98,102	IL-13	31,36	IL-4	IL-13	3565	3596	Gene	Gene	comparison|nmod|START_ENTITY properties|dep|comparison properties|nmod|END_ENTITY	Immunoregulatory properties of IL-13 in patients with inflammatory_bowel_disease ; comparison with IL-4 and IL-10 .
9224205	0	IL-4	78,82	IL-13	0,5	IL-4	IL-13	3565	3596	Gene	Gene	expression|compound|START_ENTITY comparison|nmod|expression mRNA|dep|comparison mRNA|compound|END_ENTITY	IL-13 mRNA and immunoreactivity in allergen-induced rhinitis : comparison with IL-4 expression and modulation by topical glucocorticoid therapy .
9647227	0	IL-4	146,150	IL-13	82,87	IL-4	IL-13	3565	3596	Gene	Gene	study|nmod|START_ENTITY regulation|dep|study regulation|nmod|pathway pathway|nmod|END_ENTITY	Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells : a comparative study with IL-4 .
9856950	0	IL-4	39,43	IL-13	16,21	IL-4	IL-13	16189(Tax:10090)	16163(Tax:10090)	Gene	Gene	independently|nmod|START_ENTITY independently|compound|END_ENTITY	Requirement for IL-13 independently of IL-4 in experimental asthma .
25493691	0	IL-4	62,66	IL-17A	0,6	IL-4	IL-17A	3565	3605	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|Expression Expression|compound|END_ENTITY	IL-17A Expression in HIV-Specific CD8 T Cells Is Regulated by IL-4 / IL-13 Following HIV-1 Prime-Boost Immunization .
10570181	0	IL-4	70,74	IL-18	0,5	IL-4	IL-18	16189(Tax:10090)	16173(Tax:10090)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	IL-18 , although antiallergic when administered with IL-12 , stimulates IL-4 and histamine release by basophils .
11035433	0	IL-4	78,82	IL-18	39,44	IL-4	IL-18	3565	3606	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|cytokine cytokine|dep|IL-12 IL-12|compound|END_ENTITY	Elevation of proinflammatory cytokine -LRB- IL-18 , IL-17 , IL-12 -RRB- and Th2 cytokine -LRB- IL-4 -RRB- concentrations in patients with systemic_lupus_erythematosus .
11145671	0	IL-4	15,19	IL-18	0,5	IL-4	IL-18	16189(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes : a pro-Th2 effect of IL-18 exerted through NKT cells .
11145671	0	IL-4	15,19	IL-18	88,93	IL-4	IL-18	16189(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|parataxis|exerted exerted|nsubj|effect effect|nmod|END_ENTITY	IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes : a pro-Th2 effect of IL-18 exerted through NKT cells .
14522096	0	IL-4	38,42	IL-1B	17,22	IL-4	IL-1B	3565	3553	Gene	Gene	IL-10|dep|START_ENTITY IL-10|compound|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
24819208	0	IL-4	82,86	IL-1RA	95,101	IL-4	IL-1RA	3565	3557	Gene	Gene	association|nmod|START_ENTITY association|dep|END_ENTITY	Gene polymorphisms and febrile_neutropenia in acute_leukemia -- no association with IL-4 , CCR-5 , IL-1RA , but the MBL-2 , ACE , and TLR-4 are associated with the disease in Turkish patients : a preliminary study .
8836916	0	IL-4	26,30	IL-1RA	60,66	IL-4	IL-1RA	3565	3554	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Dexamethasone antagonizes IL-4 and IL-10-induced release of IL-1RA by monocytes but augments IL-4 - , IL-10 - , and TGF-beta-induced suppression of TNF-alpha release .
14522096	0	IL-4	38,42	IL-1RN	24,30	IL-4	IL-1RN	3565	3557	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
12954239	0	IL-4	94,98	IL-1_alpha	31,41	IL-4	IL-1 alpha	280824(Tax:9913)	281250(Tax:9913)	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
2785566	0	IL-4	0,4	IL-1_and_TNF	20,32	IL-4	IL-1 and TNF	3565	3553;7124	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	IL-4 down-regulates IL-1_and_TNF gene expression in human monocytes .
1698865	0	IL-4	0,4	IL-1_beta	31,40	IL-4	IL-1 beta	3565	3553	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	IL-4 acts synergistically with IL-1_beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular_cell_adhesion_molecule-1 .
2129394	0	IL-4	47,51	IL-1_beta	55,64	IL-4	IL-1 beta	3565	3553	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Cytokine gene expression in atopics : effect of IL-4 on IL-1_beta and IL-6 mRNA levels .
1386096	0	IL-4	0,4	IL-1_receptor_antagonist	18,42	IL-4	IL-1 receptor antagonist	3565	3557	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	IL-4 up-regulates IL-1_receptor_antagonist gene expression and its production in human blood monocytes .
9776110	0	IL-4	81,85	IL-1alpha	38,47	IL-4	IL-1alpha	3565	3552	Gene	Gene	IL-2|dep|START_ENTITY pro-inflammatory|appos|IL-2 pro-inflammatory|appos|TNF-alpha TNF-alpha|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
10201960	0	IL-4	107,111	IL-2	88,92	IL-4	IL-2	3565	3558	Gene	Gene	express|nmod|START_ENTITY express|nmod|END_ENTITY	Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4 .
10224467	0	IL-4	0,4	IL-2	56,60	IL-4	IL-2	3565	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|chain chain|compound|END_ENTITY	IL-4 inhibits human CD8 T cell expression of the common IL-2 receptor gamma chain .
10457402	0	IL-4	58,62	IL-2	52,56	IL-4	IL-2	3565	3558	Gene	Gene	IFNgamma|dep|START_ENTITY IFNgamma|dep|END_ENTITY	Peripheral T lymphocyte cytokine profile -LRB- IFNgamma , IL-2 , IL-4 -RRB- and CD30 expression/release during measles_infection .
10497110	0	IL-4	15,19	IL-2	53,57	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY levels|nmod|mRNA levels|nmod|mRNA mRNA|compound|END_ENTITY	High levels of IL-4 and IL-10 mRNA and low levels of IL-2 , IL-9 and IFN-gamma mRNA in MuLV-induced lymphomas .
10525317	0	IL-4	66,70	IL-2	37,41	IL-4	IL-2	3565	3558	Gene	Gene	cytokines|appos|START_ENTITY _|dobj|cytokines _|nsubj|detection detection|appos|END_ENTITY	Flow cytometric detection of type 1 -LRB- IL-2 , IFN-gamma -RRB- _ and_type_2 -LRB- IL-4 , IL-5 -RRB- cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid_arthritis , allergic_asthma and atopic_dermatitis .
10984195	0	IL-4	26,30	IL-2	8,12	IL-4	IL-2	3565	3558	Gene	Gene	IL-6|compound|START_ENTITY elevated|dobj|IL-6 elevated|nsubj|END_ENTITY	Reduced IL-2 but elevated IL-4 , IL-6 , and IgE serum levels in patients with cerebral_infarction during the acute stage .
11991671	0	IL-4	120,124	IL-2	115,119	IL-4	IL-2	3565	3558	Gene	Gene	gamma_chain|compound|START_ENTITY gamma_chain|compound|END_ENTITY	Endogenous interferon-alpha production by differentiating human monocytes regulates expression and function of the IL-2 / IL-4 receptor gamma_chain .
12534941	0	IL-4	0,4	IL-2	64,68	IL-4	IL-2	287287(Tax:10116)	116562(Tax:10116)	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|confers confers|nsubj|END_ENTITY	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
1349533	0	IL-4	75,79	IL-2	84,88	IL-4	IL-2	3565	3558	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Interleukin _ -LRB- IL -RRB- -4 production by human T cells : differential regulation of IL-4 vs. IL-2 production .
1362565	0	IL-4	97,101	IL-2	92,96	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production presentation|parataxis|regulated presentation|nmod|antigen-presenting_cells antigen-presenting_cells|acl|induce induce|dobj|END_ENTITY	Antigen presentation by murine splenic , but not hepatic , antigen-presenting_cells to induce IL-2 / IL-4 production from immune T cells is regulated by interactions between LFA-1 / ICAM-1 .
1431136	0	IL-4	0,4	IL-2	16,20	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	influences|nsubj|START_ENTITY influences|dobj|production production|compound|END_ENTITY	IL-4 influences IL-2 production and granulomatous_inflammation in murine schistosomiasis mansoni .
14522096	0	IL-4	38,42	IL-2	32,36	IL-4	IL-2	3565	3558	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
1531844	0	IL-4	0,4	IL-2	69,73	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	suppresses|compound|START_ENTITY cytokine|nsubj|suppresses cytokine|dobj|expression expression|acl|induced induced|nmod|END_ENTITY	IL-4 suppresses cytokine gene expression induced by IFN-gamma and/or IL-2 in murine peritoneal macrophages .
1588041	0	IL-4	0,4	IL-2	13,17	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes .
1674955	0	IL-4	0,4	IL-2	14,18	IL-4	IL-2	3565	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|compound|END_ENTITY	IL-4 inhibits IL-2 synthesis and IL-2-induced up-regulation of IL-2R_alpha but not IL-2R_beta chain in CD4 + human T cells .
17392576	0	IL-4	170,174	IL-2	164,168	IL-4	IL-2	3565	3558	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
1824774	0	IL-4	63,67	IL-2	15,19	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	stimulated|nmod|START_ENTITY Suppression|acl|stimulated Suppression|nmod|END_ENTITY	Suppression by IL-2 of IgE production by B cells stimulated by IL-4 .
1827817	0	IL-4	0,4	IL-2	15,19	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	IL-4 increases IL-2 production by T cells in response to accessory cell-independent stimuli .
1907310	1	IL-4	122,126	IL-2	137,141	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|mRNA mRNA|amod|END_ENTITY	I. IL-4 mRNA , not IL-2 mRNA , is abundant in the granulomatous livers , mesenteric lymph nodes , and spleens of infected mice .
1940368	0	IL-4	0,4	IL-2	44,48	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	IL-4 inhibits the costimulatory activity of IL-2 or picolinic_acid but not of lipopolysaccharide on IFN-gamma-treated macrophages .
1968430	1	IL-4	167,171	IL-2	114,118	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	secrete|dobj|START_ENTITY clones|acl:relcl|secrete rise|nmod|clones rise|nsubj|Evidence Evidence|dep|give give|nsubj|clones clones|acl|secreting secreting|dobj|END_ENTITY	Evidence that clones secreting IL-2 and IL-4 give rise to clones which secrete only IL-4 .
1968925	0	IL-4	0,4	IL-2	14,18	IL-4	IL-2	3565	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells .
2102812	0	IL-4	22,26	IL-2	55,59	IL-4	IL-2	3565	3558	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of IL-4 on human B-cell response to IL-2 .
2105854	0	IL-4	55,59	IL-2	0,4	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY have|dobj|effects have|nsubj|END_ENTITY	IL-2 , IL-6 , and IFN-gamma have distinct effects on the IL-4 plus PMA-induced proliferation of thymocyte subpopulations .
2117636	0	IL-4	29,33	IL-2	73,77	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	interleukin_4|appos|START_ENTITY Generation|nmod|interleukin_4 Generation|dep|END_ENTITY	Generation of interleukin_4 -LRB- IL-4 -RRB- - producing cells in vivo and in vitro : IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells .
2129798	0	IL-4	51,55	IL-2	96,100	IL-4	IL-2	3565	3558	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Functional and phenotypic modifications induced by IL-4 , as single agent or in combination with IL-2 , on PBMC preactivated in vivo by alpha-interferon + interleukin-2 therapy .
2143207	1	IL-4	67,71	IL-2	46,50	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|END_ENTITY	IL-2 is required for IL-4 production .
2329278	0	IL-4	0,4	IL-2	33,37	IL-4	IL-2	3565	3558	Gene	Gene	blocks|nsubj|START_ENTITY blocks|dobj|up-regulation up-regulation|nmod|receptors receptors|compound|END_ENTITY	IL-4 blocks the up-regulation of IL-2 receptors induced by IL-2 in normal human B cells .
2329278	0	IL-4	0,4	IL-2	59,63	IL-4	IL-2	3565	3558	Gene	Gene	blocks|nsubj|START_ENTITY blocks|dobj|up-regulation up-regulation|nmod|receptors receptors|acl|induced induced|nmod|END_ENTITY	IL-4 blocks the up-regulation of IL-2 receptors induced by IL-2 in normal human B cells .
2380552	0	IL-4	0,4	IL-2	46,50	IL-4	IL-2	3565	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|receptors receptors|compound|END_ENTITY	IL-4 inhibits the expression of high affinity IL-2 receptors on monoclonal human B cells .
2394464	1	IL-4	165,169	IL-2	103,107	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	secrete|dobj|START_ENTITY induces|advcl|secrete induces|advmod|END_ENTITY	Human , but not mouse , IL-2 induces a functionally immature thymic subset to secrete IL-4 and become CTL .
2397500	0	IL-4	0,4	IL-2	130,134	IL-4	IL-2	3565	3558	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|response response|nmod|clone clone|dep|correlates correlates|nmod|END_ENTITY	IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2 , but not with a modified IL-2_receptor expression .
2397500	0	IL-4	0,4	IL-2	33,37	IL-4	IL-2	3565	3558	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|response response|compound|END_ENTITY	IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2 , but not with a modified IL-2_receptor expression .
25272942	0	IL-4	32,36	IL-2	26,30	IL-4	IL-2	3565	3558	Gene	Gene	IL-17|compound|START_ENTITY IFN-gamma|dep|IL-17 IFN-gamma|dep|END_ENTITY	The cytokines -LRB- IFN-gamma , IL-2 , IL-4 , IL-10 , IL-17 -RRB- and Treg cytokine -LRB- TGF-beta1 -RRB- levels in adults with immune_thrombocytopenia .
2654291	0	IL-4	0,4	IL-2	15,19	IL-4	IL-2	3565	3558	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|induction induction|compound|END_ENTITY	IL-4 regulates IL-2 induction of lymphokine-activated killer activity from human lymphocytes .
2893823	0	IL-4	69,73	IL-2	32,36	IL-4	IL-2	3565	3558	Gene	Gene	Proliferation|dep|START_ENTITY Proliferation|nmod|END_ENTITY	Proliferation and production of IL-2 and B_cell_stimulatory_factor_1 / IL-4 in early fetal thymocytes by activation through Thy-1 and CD3 .
3265652	0	IL-4	18,22	IL-2	57,61	IL-4	IL-2	3565	3558	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|induction induction|nmod|END_ENTITY	Human recombinant IL-4 suppresses the induction of human IL-2 induced lymphokine activated killer -LRB- LAK -RRB- activity .
7520376	0	IL-4	141,145	IL-2	10,14	IL-4	IL-2	3565	3558	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|effect Effect|dep|effect Effect|nmod|END_ENTITY	Effect of IL-2 on immunoglobulin production by anti-CD40-activated human B cells : synergistic effect with IL-10 and antagonistic effect with IL-4 .
7621236	0	IL-4	6,10	IL-2	98,102	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	delivery|compound|START_ENTITY enhances|nsubj|delivery enhances|parataxis|therapy therapy|nmod|combination combination|nmod|END_ENTITY	Local IL-4 delivery enhances immune reactivity to murine tumors : gene therapy in combination with IL-2 .
7819141	0	IL-4	18,22	IL-2	88,92	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	cAMP|dobj|START_ENTITY cAMP|advcl|decreasing decreasing|dobj|release release|compound|END_ENTITY	cAMP up-regulates IL-4 and IL-5 production from activated CD4 + T cells while decreasing IL-2 release and NF-AT induction .
8015314	0	IL-4	125,129	IL-2	85,89	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY production|dep|release production|amod|END_ENTITY	Polymicrobial sepsis but not low-dose endotoxin infusion causes decreased splenocyte IL-2 / IFN-gamma release while increasing IL-4 / IL-10 production .
8035820	0	IL-4	114,118	IL-2	78,82	IL-4	IL-2	3565	3558	Gene	Gene	chain|nmod|START_ENTITY gamma|dobj|chain gamma|nsubj|Evidence Evidence|nmod|role role|nmod|region region|nmod|receptor receptor|appos|END_ENTITY	Evidence for a critical role for the cytoplasmic region of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma chain in IL-2 , IL-4 , and IL-7 signalling .
8231167	0	IL-4	0,4	IL-2	14,18	IL-4	IL-2	3565	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|compound|END_ENTITY	IL-4 inhibits IL-2 induction of LAK cytotoxicity in lymphocytes from a variety of lymphoid tissues .
8270872	0	IL-4	107,111	IL-2	46,50	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY priming|nmod|production role|acl|priming plays|dobj|role plays|nsubj|costimulation costimulation|nmod|production production|appos|END_ENTITY	CD28-mediated costimulation of interleukin_2 -LRB- IL-2 -RRB- production plays a critical role in T cell priming for IL-4 and interferon_gamma production .
8352529	0	IL-4	63,67	IL-2	0,4	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	IL-2 inhibits the induction of systemic antitumour immunity by IL-4 in the peritumoural treatment of experimental melanoma .
8569177	0	IL-4	112,116	IL-2	106,110	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|compound|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8621905	0	IL-4	49,53	IL-2	42,46	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	dexamethasone|dep|START_ENTITY dexamethasone|nmod|END_ENTITY	Differential activity of dexamethasone on IL-2 - , IL-4 - , or IL-9-induced proliferation of murine factor-dependent T cell lines .
8658052	0	IL-4	64,68	IL-2	58,62	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|appos|production	Fibronectin co-stimulates via the alpha 5 beta 1 receptor IL-2 , IL-4 production by splenic , granuloma lymphocytes of Schistosoma_mansoni infected mice .
9557697	0	IL-4	110,114	IL-2	261,265	IL-4	IL-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	_|appos|START_ENTITY protein|nmod|_ coexpressing|dobj|protein vaccinia_virus|acl|coexpressing inhibit|nsubj|vaccinia_virus inhibit|advcl|diminished diminished|nmod|presence presence|nmod|levels levels|nmod|interferon interferon|compound|END_ENTITY	Recombinant vaccinia_virus coexpressing the F protein of respiratory_syncytial_virus _ -LRB- RSV -RRB- and interleukin-4 -LRB- IL-4 -RRB- does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes , whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon .
9558115	0	IL-4	72,76	IL-2	19,23	IL-4	IL-2	3565	3558	Gene	Gene	control|nmod|START_ENTITY Involvement|nmod|control Involvement|nmod|gamma-chain gamma-chain|compound|END_ENTITY	Involvement of the IL-2 receptor gamma-chain -LRB- gammac -RRB- in the control by IL-4 of human monocyte and macrophage proinflammatory mediator production .
1334461	0	IL-4	0,4	IL-3	59,63	IL-4	IL-3	16189(Tax:10090)	16187(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells .
1717495	0	IL-4	53,57	IL-3	47,51	IL-4	IL-3	287287(Tax:10116)	24495(Tax:10116)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nsubj|formation formation|acl|supported supported|nmod|END_ENTITY	Murine mast cell colony formation supported by IL-3 , IL-4 , and recombinant rat stem_cell_factor , ligand for c-kit .
19098920	0	IL-4	101,105	IL-3	57,61	IL-4	IL-3	3565	3562	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|Fc_receptor_gamma-chain Fc_receptor_gamma-chain|appos|component component|nmod|receptor receptor|compound|END_ENTITY	Fc_receptor_gamma-chain , a constitutive component of the IL-3 receptor , is required for IL-3-induced IL-4 production in basophils .
2145362	0	IL-4	28,32	IL-3	0,4	IL-4	IL-3	16189(Tax:10090)	16187(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	IL-3 promotes production of IL-4 by splenic non-B , non-T cells in response to Fc_receptor cross-linkage .
25824485	0	IL-4	38,42	IL-3	0,4	IL-4	IL-3	3565	3562	Gene	Gene	synergises|nmod|START_ENTITY synergises|nsubj|END_ENTITY	IL-3 synergises with basophil-derived IL-4 and IL-13 to promote the alternative activation of human monocytes .
2680112	0	IL-4	64,68	IL-3	108,112	IL-4	IL-3	3565	3562	Gene	Gene	lines|dep|START_ENTITY regulation|nmod|lines modulate|nsubj|regulation modulate|dobj|growth growth|amod|END_ENTITY	Growth regulation of multi-factor-dependent myeloid cell lines : IL-4 , TGF-beta and pertussis toxin modulate IL-3 - or GM-CSF-induced growth by controlling cell cycle length .
2902144	0	IL-4	4,8	IL-3	60,64	IL-4	IL-3	16189(Tax:10090)	16187(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY maps|nsubj|gene maps|nmod|END_ENTITY	The IL-4 gene maps to chromosome 11 , near the gene encoding IL-3 .
7751024	0	IL-4	0,4	IL-3	14,18	IL-4	IL-3	3565	3562	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line .
7871561	0	IL-4	68,72	IL-3	62,66	IL-4	IL-3	3565	3562	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
8568251	0	IL-4	46,50	IL-3	15,19	IL-4	IL-3	16189(Tax:10090)	16187(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	T cell-derived IL-3 induces the production of IL-4 by non-B , non-T cells to amplify the Th2-cytokine response to a non-parasite antigen in Schistosoma_mansoni-infected mice .
8647228	0	IL-4	15,19	IL-3	89,93	IL-4	IL-3	16189(Tax:10090)	16187(Tax:10090)	Gene	Gene	reverses|nsubj|START_ENTITY reverses|dobj|effect effect|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- in combination with IL-11 or IL-6 reverses the inhibitory effect of IL-3 on early B lymphocyte development .
8818544	0	IL-4	25,29	IL-3	0,4	IL-4	IL-3	3565	3562	Gene	Gene	induces|nmod|START_ENTITY induces|dep|END_ENTITY	IL-3 in combination with IL-4 , induces the expression of functional CD1 molecules on monocytes .
9433149	0	IL-4	111,115	IL-3	105,109	IL-4	IL-3	3565	3562	Gene	Gene	START_ENTITY|nsubj|therapy therapy|appos|END_ENTITY	Recombinant human granulocyte-macrophage_colony-stimulating_factor therapy and endogenous plasma GM-CSF , _ IL-3 , IL-4 concentrations in pediatric patients with solid_tumors .
17030248	0	IL-4	51,55	IL-31	30,35	IL-4	IL-31	3565	386653	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|nmod|END_ENTITY	Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic_contact_dermatitis .
23694808	0	IL-4	26,30	IL-31	6,11	IL-4	IL-31	3565	386653	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation .
9378959	0	IL-4	0,4	IL-4	73,77	IL-4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY dependent|nsubj|production dependent|advmod|END_ENTITY	IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent .
9378959	0	IL-4	73,77	IL-4	0,4	IL-4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|production production|compound|END_ENTITY	IL-4 and IL-13 production in differentiated T helper type 2 cells is not IL-4 dependent .
9380721	0	IL-4	18,22	IL-4	60,64	IL-4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	interleukin_4|appos|START_ENTITY interleukin_4|dep|mice mice|amod|independent independent|ccomp|revealed revealed|nsubjpass|production production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9380721	0	IL-4	60,64	IL-4	18,22	IL-4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY revealed|nsubjpass|production independent|ccomp|revealed mice|amod|independent interleukin_4|dep|mice interleukin_4|appos|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9380721	0	IL-4	60,64	IL-4	91,95	IL-4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY revealed|nsubjpass|production revealed|nmod|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9380721	0	IL-4	91,95	IL-4	60,64	IL-4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	revealed|nmod|START_ENTITY revealed|nsubjpass|production production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
8548394	0	IL-4	91,95	IL-4-R	106,112	IL-4	IL-4-R	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Modulation of the immunoglobulin dysregulation in GvH - and SLE-like diseases by the murine IL-4 receptor -LRB- IL-4-R -RRB- .
24403255	0	IL-4	14,18	IL-4Ra	33,39	IL-4	IL-4Ra	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	IL-13 but not IL-4 signaling via IL-4Ra protects mice from papilloma formation during DMBA/TPA two-step skin_carcinogenesis .
24966389	0	IL-4	0,4	IL-4Ra	158,164	IL-4	IL-4Ra	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	drives|compound|START_ENTITY drives|parataxis|consequences consequences|nmod|END_ENTITY	IL-4 signaling drives a unique arginase + / IL-1b + microglia phenotype and recruits macrophages to the inflammatory CNS : consequences of age-related deficits in IL-4Ra after traumatic spinal_cord_injury .
26044177	0	IL-4	100,104	IL-4Ra	70,76	IL-4	IL-4Ra	3565	3566	Gene	Gene	Signalling|compound|START_ENTITY Antagonist|nmod|Signalling Antagonist|nsubj|Identification Identification|appos|END_ENTITY	Identification and Characterization of a Novel IL-4_Receptor_a_Chain -LRB- IL-4Ra -RRB- Antagonist to Inhibit IL-4 Signalling .
26993600	0	IL-4	35,39	IL-4Ra	84,90	IL-4	IL-4Ra	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY suppressive|dobj|effect suppressive|nmod|activation activation|nmod|STAT6 STAT6|nmod|models models|compound|END_ENTITY	Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Ra overexpressed_melanoma models .
12902491	0	IL-4	19,23	IL-4Ralpha	127,137	IL-4	IL-4Ralpha	3565	3566	Gene	Gene	receptor|compound|START_ENTITY programming|nmod|receptor signal|nsubj|programming signal|parataxis|mediated mediated|nmod|END_ENTITY	New programming of IL-4 receptor signal transduction in activated T cells : Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines .
16503977	0	IL-4	0,4	IL-4Ralpha	27,37	IL-4	IL-4Ralpha	3565	3566	Gene	Gene	alpha|dep|START_ENTITY receptor|amod|alpha receptor|appos|END_ENTITY	IL-4 alpha chain receptor -LRB- IL-4Ralpha -RRB- polymorphisms in allergic bronchopulmonary_sspergillosis .
17189592	0	IL-4	41,45	IL-4Ralpha	0,10	IL-4	IL-4Ralpha	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY regulation|nmod|synthesis polymorphism|nmod|regulation polymorphism|amod|END_ENTITY	IL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus .
18029018	0	IL-4	7,11	IL-4Ralpha	49,59	IL-4	IL-4Ralpha	3565	3566	Gene	Gene	START_ENTITY|acl:relcl|able able|xcomp|signal signal|nmod|END_ENTITY	Murine IL-4 is able to signal via chimeric human IL-4Ralpha / mouse gamma-chain receptor .
18198661	0	IL-4	16,20	IL-4Ralpha	22,32	IL-4	IL-4Ralpha	3565	3566	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Skeletal muscle IL-4 , IL-4Ralpha , IL-13 and IL-13Ralpha1 expression and response to strength training .
18852293	0	IL-4	22,26	IL-4Ralpha	65,75	IL-4	IL-4Ralpha	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	Tuning|nmod|START_ENTITY Tuning|parataxis|regulates regulates|nsubj|expression expression|nmod|END_ENTITY	Tuning sensitivity to IL-4 and IL-13 : differential expression of IL-4Ralpha , IL-13Ralpha1 , and gammac regulates relative cytokine sensitivity .
19799897	0	IL-4	110,114	IL-4Ralpha	131,141	IL-4	IL-4Ralpha	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	chains|compound|START_ENTITY chains|amod|END_ENTITY	Oncostatin_M -LRB- OSM -RRB- primes IL-13 - _ and_IL-4-induced eotaxin responses in fibroblasts : regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1 .
24742632	0	IL-4	53,57	IL-4_receptor	58,71	IL-4	IL-4 receptor	3565	3566	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association between genes encoding components of the IL-4 / IL-4_receptor pathway and dermatitis in children .
10880839	0	IL-4	68,72	IL-5	73,77	IL-4	IL-5	3565	3567	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Multiple HLA-class I-specific inhibitory NK receptor expression and IL-4 / IL-5 production by CD8 + T-cell clones in HIV-1_infection .
10922233	0	IL-4	53,57	IL-5	36,40	IL-4	IL-5	3565	3567	Gene	Gene	not|nmod|START_ENTITY END_ENTITY|dep|not	Allergen-induced mRNA expression of IL-5 , but not of IL-4 and IFN-gamma , in peripheral blood mononuclear cells is a key feature of clinical manifestation of seasonal_allergic_rhinitis .
12150887	0	IL-4	0,4	IL-5	74,78	IL-4	IL-5	16189(Tax:10090)	16191(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|absence absence|nmod|END_ENTITY	IL-4 induces characteristic Th2 responses even in the combined absence of IL-5 , IL-9 , and IL-13 .
1347306	1	IL-4	219,223	IL-5	173,177	IL-4	IL-5	3565	3567	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement by IL-5 , specific inhibition of IgA synthesis by IL-4 .
14634065	0	IL-4	148,152	IL-5	140,144	IL-4	IL-5	3565	3567	Gene	Gene	priming|compound|START_ENTITY END_ENTITY|nmod|priming	Comparative cytokine profile of human skin mast cells from two compartments -- strong resemblance with monocytes at baseline but induction of IL-5 by IL-4 priming .
1552290	0	IL-4	71,75	IL-5	15,19	IL-4	IL-5	16189(Tax:10090)	16191(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY signal|acl:relcl|required provides|dobj|signal provides|nsubj|Interleukin_5 Interleukin_5|appos|END_ENTITY	Interleukin_5 -LRB- IL-5 -RRB- provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin -LRB- Ig -RRB- G1 and IgE .
16929824	0	IL-4	37,41	IL-5	43,47	IL-4	IL-5	3565	3567	Gene	Gene	concentration|nmod|START_ENTITY -LSB-|dobj|concentration -RSB-|advcl|-LSB- -RSB-|nsubj|tissues tissues|compound|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17392576	0	IL-4	170,174	IL-5	176,180	IL-4	IL-5	3565	3567	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
1830499	0	IL-4	86,90	IL-5	93,97	IL-4	IL-5	16189(Tax:10090)	16191(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|appos|END_ENTITY	Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 -LRB- IL-4 -RRB- , IL-5 , and gamma-interferon , but not IL-2 by activated murine T cells .
2295790	0	IL-4	22,26	IL-5	0,4	IL-4	IL-5	3565	3567	Gene	Gene	up-regulates|nmod|START_ENTITY up-regulates|compound|END_ENTITY	IL-5 up-regulates but IL-4 down-regulates IL-2R expression on a cloned B_lymphoma line .
25330644	0	IL-4	56,60	IL-5	62,66	IL-4	IL-5	287287(Tax:10116)	24497(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY -LSB-|nmod|expression -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- Prophylactic effect of budesonide on the expression of IL-4 , IL-5 in model of allergic_rhinitis rats -RSB- .
26224246	0	IL-4	151,155	IL-5	157,161	IL-4	IL-5	16189(Tax:10090)	16191(Tax:10090)	Gene	Gene	START_ENTITY|appos|balance balance|compound|END_ENTITY	Treg depletion attenuates irradiation-induced pulmonary_fibrosis by reducing fibrocyte accumulation , inducing Th17 response , and shifting IFN-y , IL-12 / IL-4 , IL-5 balance .
7730620	0	IL-4	73,77	IL-5	14,18	IL-4	IL-5	3565	3567	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Production Production|nmod|END_ENTITY	Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4 , IL-10 , and IL-12 .
7917114	0	IL-4	15,19	IL-5	21,25	IL-4	IL-5	3565	3567	Gene	Gene	IL-10|appos|START_ENTITY IL-10|appos|END_ENTITY	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
8920874	0	IL-4	38,42	IL-5	72,76	IL-4	IL-5	16189(Tax:10090)	16191(Tax:10090)	Gene	Gene	production|compound|START_ENTITY dependent|nsubj|production dependent|nmod|END_ENTITY	Schistosoma_mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils .
9037001	7	IL-4	1363,1367	IL-5	1458,1462	IL-3	IL-4	16187(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|reaction reaction|nmod|effects effects|nmod|expression expression|amod|END_ENTITY	The cytokine mRNA profile correlating with the lack of eosinophil recruitment was variable ; the data suggest that IL-4 regulates eosinophil involvement in the xeno-rejection reaction indirectly via effects on IL-5 and IL-3 transcript expression .
9470918	0	IL-4	22,26	IL-5	28,32	IL-4	IL-5	3565	3567	Gene	Gene	expression|nmod|START_ENTITY mRNAs|nmod|expression mRNAs|nsubj|END_ENTITY	In vivo expression of IL-4 , IL-5 , IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin_A in a patient with Kimura 's _ disease .
10076053	0	IL-4	15,19	IL-6	64,68	IL-4	IL-6	3565	3569	Gene	Gene	Interleukin-4|appos|START_ENTITY regulates|nsubj|Interleukin-4 regulates|dobj|synthesis synthesis|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- , but not IL-10 , regulates the synthesis of IL-6 , IL-8 and leukemia_inhibitory_factor by human bone marrow stromal cells .
10547270	0	IL-4	27,31	IL-6	63,67	IL-4	IL-6	3565	3569	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|amod|END_ENTITY	Differential regulation by IL-4 and IL-10 of radiation-induced IL-6 and IL-8 production and ICAM-1 expression by human endothelial cells .
10566657	0	IL-4	118,122	IL-6	125,129	IL-4	IL-6	3565	3569	Gene	Gene	increases|appos|START_ENTITY increases|appos|END_ENTITY	Effect of radioactive iodine therapy on cytokine production in Graves ' _ disease : transient increases in interleukin-4 -LRB- IL-4 -RRB- , IL-6 , IL-10 , and tumor_necrosis_factor-alpha , with longer term increases in interferon-gamma production .
10734320	0	IL-4	0,4	IL-6	19,23	IL-4	IL-6	3565	3569	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	IL-4 regulation of IL-6 production involves Rac/Cdc42 - and p38_MAPK-dependent pathways in keratinocytes .
11529906	0	IL-4	86,90	IL-6	34,38	IL-4	IL-6	3565	3569	Gene	Gene	IFN-gamma|dep|START_ENTITY cytokines|appos|IFN-gamma cytokines|amod|cytokines cytokines|dep|IL-17 IL-17|appos|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
12217330	0	IL-4	0,4	IL-6	13,17	IL-4	IL-6	3565	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IL-4 induces IL-6 and signs of allergic-type_inflammation in the nasal airways of nonallergic individuals .
12954239	0	IL-4	94,98	IL-6	43,47	IL-4	IL-6	280824(Tax:9913)	517016(Tax:9913)	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|IL-1_alpha IL-1_alpha|dep|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
14522096	0	IL-4	38,42	IL-6	44,48	IL-4	IL-6	3565	3569	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
1478697	0	IL-4	53,57	IL-6	83,87	IL-4	IL-6	3565	3569	Gene	Gene	induced|nmod|START_ENTITY lymphoma|acl|induced Proliferation|nmod|lymphoma dependent|nsubj|Proliferation dependent|nmod|END_ENTITY	Proliferation of the BCL1 B cell lymphoma induced by IL-4 and IL-5 is dependent on IL-6 and GM-CSF .
16929824	0	IL-4	37,41	IL-6	49,53	IL-4	IL-6	3565	3569	Gene	Gene	concentration|nmod|START_ENTITY -LSB-|dobj|concentration -RSB-|advcl|-LSB- -RSB-|nsubj|tissues tissues|dep|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17392576	0	IL-4	170,174	IL-6	182,186	IL-4	IL-6	3565	3569	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
2118969	0	IL-4	12,16	IL-6	26,30	IL-4	IL-6	3565	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|compound|END_ENTITY	Recombinant IL-4 inhibits IL-6 synthesis by adherent peripheral blood cells in vitro .
22405769	0	IL-4	23,27	IL-6	146,150	IL-4	IL-6	3565	3569	Gene	Gene	cytokines|amod|START_ENTITY elicit|nsubj|cytokines elicit|nmod|action action|nmod|END_ENTITY	Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-a on macrophages through the autocrine action of IL-6 .
24578755	0	IL-4	27,31	IL-6	33,37	IL-4	IL-6	3565	3569	Gene	Gene	Assessment|nmod|START_ENTITY Assessment|amod|IL-8 IL-8|amod|END_ENTITY	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
2967865	0	IL-4	108,112	IL-6	18,22	IL-4	IL-6	16189(Tax:10090)	16193(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY END_ENTITY|acl:relcl|enhances	Identification of IL-6 as a T cell-derived factor that enhances the proliferative response of thymocytes to IL-4 and phorbol_myristate_acetate .
7871561	0	IL-4	68,72	IL-6	74,78	IL-4	IL-6	3565	3569	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
7954438	0	IL-4	140,144	IL-6	146,150	IL-4	IL-6	16189(Tax:10090)	16193(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8228249	0	IL-4	49,53	IL-6	30,34	IL-4	IL-6	3565	3569	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	Tissue-specific regulation of IL-6 production by IL-4 .
8440075	0	IL-4	37,41	IL-6	46,50	IL-4	IL-6	3565	3569	Gene	Gene	effect|appos|START_ENTITY effect|nmod|production production|compound|END_ENTITY	Suppressive effect of interleukin-4 -LRB- IL-4 -RRB- on IL-6 production by adherent rheumatoid synovial cells .
8554685	0	IL-4	23,27	IL-6	29,33	IL-4	IL-6	3565	3569	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
8613355	0	IL-4	36,40	IL-6	148,152	IL-4	IL-6	16189(Tax:10090)	16193(Tax:10090)	Gene	Gene	interleukin-4|appos|START_ENTITY immunization|nmod|interleukin-4 reveals|nsubj|immunization reveals|ccomp|associated associated|nsubjpass|cells cells|acl|producing producing|xcomp|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8640150	0	IL-4	88,92	IL-6	59,63	IL-4	IL-6	3565	3569	Gene	Gene	IL-2|dep|START_ENTITY monocytes|appos|IL-2 monocytes|appos|IL-1_beta IL-1_beta|dep|END_ENTITY	-LSB- Production of selected cytokines by monocytes -LRB- IL-1_beta , IL-6 -RRB- and lymphocytes -LRB- IL-2 , IL-4 -RRB- in peripheral blood of patients with nonallergic bronchial_asthma treated with Broncho-Vaxom -RSB- .
8786324	0	IL-4	69,73	IL-6	27,31	IL-4	IL-6	3565	3569	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|transcription transcription|compound|END_ENTITY	Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines .
9562370	0	IL-4	58,62	IL-6	0,4	IL-4	IL-6	3565	3569	Gene	Gene	B-lymphocytes|compound|START_ENTITY inhibit|nmod|B-lymphocytes inhibit|nsubj|oligonucleotides oligonucleotides|compound|END_ENTITY	IL-6 antisense oligonucleotides inhibit IgE production in IL-4 and anti-CD40-stimulated human B-lymphocytes .
9776110	0	IL-4	81,85	IL-6	49,53	IL-4	IL-6	3565	3569	Gene	Gene	IL-2|dep|START_ENTITY pro-inflammatory|appos|IL-2 pro-inflammatory|appos|TNF-alpha TNF-alpha|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
7596167	0	IL-4	224,228	IL-7	229,233	IL-4	IL-7	3565	3574	Gene	Gene	START_ENTITY|dep|receptor receptor|compound|END_ENTITY	Heterogeneity of proliferative responses of human B cell precursor acute_lymphoblastic_leukemia -LRB- BCP-ALL -RRB- cells to interleukin_7 -LRB- IL-7 -RRB- : no correlation with immunoglobulin gene status and expression of IL-7 receptor or IL-2 / IL-4 / IL-7 receptor common_gamma_chain genes .
7954438	0	IL-4	140,144	IL-7	152,156	IL-4	IL-7	16189(Tax:10090)	16196(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8569177	0	IL-4	112,116	IL-7	118,122	IL-4	IL-7	16189(Tax:10090)	16196(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
10372996	0	IL-4	0,4	IL-8	52,56	IL-4	IL-8	3565	3576	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	IL-4 potentiates IL-1beta - and TNF-alpha-stimulated IL-8 and MCP-1 protein production in human retinal pigment epithelial cells .
10565568	0	IL-4	0,4	IL-8	69,73	IL-4	IL-8	3565	3576	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|xcomp|release release|dobj|END_ENTITY	IL-4 and IL-13 stimulate human bronchial epithelial cells to release IL-8 .
10725748	0	IL-4	42,46	IL-8	24,28	IL-4	IL-8	3565	3576	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|receptors receptors|amod|END_ENTITY	Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes .
1383379	0	IL-4	81,85	IL-8	15,19	IL-4	IL-8	3565	3576	Gene	Gene	induced|nmod|START_ENTITY production|acl|induced inhibits|dobj|production inhibits|nsubj|Interleukin_8 Interleukin_8|appos|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- selectively inhibits immunoglobulin_E production induced by IL-4 in human B cells .
16929824	0	IL-4	37,41	IL-8	55,59	IL-4	IL-8	3565	3576	Gene	Gene	concentration|nmod|START_ENTITY -LSB-|dobj|concentration -RSB-|advcl|-LSB- -RSB-|nsubj|tissues tissues|amod|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
2200823	0	IL-4	0,4	IL-8	32,36	IL-4	IL-8	3565	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	IL-4 inhibits the expression of IL-8 from stimulated human monocytes .
22185464	0	IL-4	7,11	IL-8	13,17	IL-4	IL-8	3565	3576	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Plasma IL-4 , IL-8 , IL-12 , interferon-y and CRP levels in pregnant women with preeclampsia , and their relation with severity of disease and fetal birth weight .
24578755	0	IL-4	27,31	IL-8	39,43	IL-4	IL-8	3565	3576	Gene	Gene	Assessment|nmod|START_ENTITY Assessment|amod|END_ENTITY	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
7864891	0	IL-4	49,53	IL-8	15,19	IL-4	IL-8	3565	3576	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|Interleukin_8 Interleukin_8|appos|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
7864891	0	IL-4	49,53	IL-8	161,165	IL-4	IL-8	3565	3576	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nmod|mechanisms mechanisms|acl:relcl|involve involve|dobj|kinase kinase|acl:relcl|inhibited inhibited|nsubj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
7871561	0	IL-4	68,72	IL-8	80,84	IL-4	IL-8	3565	3576	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
12479817	0	IL-4	20,24	IRF-1	40,45	IL-4	IRF-1	3565	3659	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 .
24518693	0	IL-4	42,46	Interleukin-4	27,40	IL-4	Interleukin-4	3565	3565	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	rs2243268 and rs2243274 of Interleukin-4 -LRB- IL-4 -RRB- gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children .
7939136	0	IL-4	15,19	Interleukin-4	0,13	IL-4	Interleukin-4	3565	3565	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces down-modulation and shedding of the p55 tumour_necrosis_factor_receptor and inhibits TNF_alpha 's effect on rheumatoid synovial fibroblasts .
1383379	0	IL-4	81,85	Interleukin_8	0,13	IL-4	Interleukin 8	3565	3576	Gene	Gene	induced|nmod|START_ENTITY production|acl|induced inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- selectively inhibits immunoglobulin_E production induced by IL-4 in human B cells .
7864891	0	IL-4	49,53	Interleukin_8	0,13	IL-4	Interleukin 8	3565	3576	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
10604995	0	IL-4	14,18	LFA-1	68,73	IL-4	LFA-1	3565	3683	Gene	Gene	responses|compound|START_ENTITY responses|acl|priming priming|nmod|context context|nmod|costimulation costimulation|compound|END_ENTITY	Inhibition of IL-4 responses after T cell priming in the context of LFA-1 costimulation is not reversed by restimulation in the presence of CD28 costimulation .
1362565	0	IL-4	97,101	LFA-1	170,175	IL-4	LFA-1	16189(Tax:10090)	16408(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production regulated|nmod|interactions interactions|nmod|ICAM-1 ICAM-1|compound|END_ENTITY	Antigen presentation by murine splenic , but not hepatic , antigen-presenting_cells to induce IL-2 / IL-4 production from immune T cells is regulated by interactions between LFA-1 / ICAM-1 .
15699483	0	IL-4	71,75	LFA-1	0,5	IL-4	LFA-1	3565	3683	Gene	Gene	responsiveness|compound|START_ENTITY differentiation|nmod|responsiveness 2|acl|differentiation T|dep|2 inhibits|nsubj|T inhibits|dep|co-stimulation co-stimulation|amod|END_ENTITY	LFA-1 co-stimulation inhibits T -LRB- h -RRB- 2 differentiation by down-modulating IL-4 responsiveness .
2547869	0	IL-4	0,4	LFA-1	13,18	IL-4	LFA-1	3565	3683	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	IL-4 induces LFA-1 and LFA-3 expression on Burkitt 's _ lymphoma cell lines .
7964512	0	IL-4	0,4	Lsk	22,25	IL-4	Lsk	3565	4145	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	IL-4 and IL-13 induce Lsk , a Csk-like tyrosine kinase , in human monocytes .
8726670	0	IL-4	97,101	M-CSF	157,162	IL-4	M-CSF	3565	1435	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Leukaemia_inhibitory_factor -LRB- LIF -RRB- production in pleural_effusions : comparison with production of IL-4 , IL-8 , IL-10 and macrophage-colony_stimulating_factor -LRB- M-CSF -RRB- .
21841136	0	IL-4	59,63	MAPK_kinase_3	0,13	IL-4	MAPK kinase 3	16189(Tax:10090)	26397(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	MAPK_kinase_3 specifically regulates Fc epsilonRI-mediated IL-4 production by mast cells .
16210650	0	IL-4	0,4	MEK	15,18	IL-4	MEK	3565	5609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-4 regulates MEK expression required for lysophosphatidic_acid-mediated chemokine generation by human mast cells .
16272308	0	IL-4	53,57	NK1	92,95	IL-4	NK1	16189(Tax:10090)	17059(Tax:10090)	Gene	Gene	inducibility|compound|START_ENTITY inducibility|nmod|CD161 CD161|appos|END_ENTITY	CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161 -LRB- NK1 -RRB- - CD44lowCD4 + CD8 - T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8 / Valpha3 .2 T cell receptor usage .
8943570	0	IL-4	36,40	NK1	14,17	IL-4	NK1	16189(Tax:10090)	17059(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	IL-7 reverses NK1 + T cell-defective IL-4 production in the non-obese_diabetic mouse .
22942430	0	IL-4	43,47	NKG2D	23,28	IL-4	NKG2D	3565	22914	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells .
22080920	0	IL-4	62,66	Ndfip1	44,50	IL-4	Ndfip1	16189(Tax:10090)	65113(Tax:10090)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	TGF-b induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation .
9712351	0	IL-4	0,4	P-glycoprotein	14,28	IL-4	P-glycoprotein	3565	5243	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IL-4 inhibits P-glycoprotein in normal and malignant NK cells .
17075267	0	IL-4	55,59	PAR-2	0,5	IL-4	PAR-2	16189(Tax:10090)	109447(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY cells|dobj|downregulation cells|nsubj|T T|compound|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
19451396	0	IL-4	57,61	Pancreatic_lipase-related_protein_2	0,35	IL-4	Pancreatic lipase-related protein 2	3565	5408	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Pancreatic_lipase-related_protein_2 -LRB- PLRP2 -RRB- induction by IL-4 in cytotoxic T lymphocytes -LRB- CTLs -RRB- and reevaluation of the negative effects of its gene ablation on cytotoxicity .
25725101	0	IL-4	52,56	Phospholipase_A2	17,33	IL-4	Phospholipase A2	3565	151056	Gene	Gene	Upregulated|nmod|START_ENTITY Upregulated|nsubjpass|END_ENTITY	Group V Secreted Phospholipase_A2 Is Upregulated by IL-4 in Human Macrophages and Mediates Phagocytosis via Hydrolysis of Ethanolamine Phospholipids .
10975998	0	IL-4	30,34	RANTES	20,26	IL-4	RANTES	3565	6352	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Modulatory roles of RANTES in IL-4 production by human blood CD4 -LRB- + -RRB- T cells .
8921438	0	IL-4	23,27	RANTES	58,64	IL-4	RANTES	3565	6352	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Contrasting effects of IL-4 , IL-10 and corticosteroids on RANTES production by human monocytes .
9644628	0	IL-4	0,4	RANTES	50,56	IL-4	RANTES	3565	6352	Gene	Gene	augment|compound|START_ENTITY END_ENTITY|nsubj|augment	IL-4 and IL-13 augment cytokine - and CD40-induced RANTES production by human renal tubular epithelial cells in vitro .
19338776	0	IL-4	15,19	Runx3	0,5	IL-4	Runx3	16189(Tax:10090)	12399(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Runx3 inhibits IL-4 production in T cells via physical interaction with NFAT .
14634100	0	IL-4	0,4	SOCS-1	22,28	IL-4	SOCS-1	3565	8651	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site .
15261459	0	IL-4	23,27	STAT-1	0,6	IL-4	STAT-1	3565	6772	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	STAT-1 is activated by IL-4 and IL-13 in multiple cell types .
19587017	0	IL-4	41,45	STAT1	0,5	IL-4	STAT1	16189(Tax:10090)	20846(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory_syncytial_virus_infection .
10611490	0	IL-4	11,15	STAT3	75,80	IL-4	STAT3	3565	6774	Gene	Gene	Binding|nmod|START_ENTITY complex|dep|Binding complex|acl:relcl|leads leads|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Binding of IL-4 to the IL-13Ralpha -LRB- 1 -RRB- / IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation .
11058569	0	IL-4	20,24	STAT3	146,151	IL-4	STAT3	3565	6774	Gene	Gene	Characterization|nmod|START_ENTITY signals|nsubj|Characterization signals|xcomp|dependent dependent|nmod|chain chain|dep|redundancy redundancy|nmod|requirement requirement|nmod|residue residue|nmod|activation activation|compound|END_ENTITY	Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1 : redundancy of requirement of tyrosine residue for STAT3 activation .
12502184	0	IL-4	74,78	STAT3	41,46	IL-4	STAT3	3565	6774	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|inhibition inhibition|nmod|activation activation|compound|END_ENTITY	IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4 , MAP kinase inhibitors and redox state of HepG2 cells .
10072514	0	IL-4	0,4	STAT6	38,43	IL-4	STAT6	3565	6778	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|isoform isoform|compound|END_ENTITY	IL-4 preferentially activates a novel STAT6 isoform in mast cells .
10452990	0	IL-4	32,36	STAT6	77,82	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY Inhibition|nmod|expression Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells : role of STAT6 and phosphatidylinositol 3 ' - kinase .
10939617	0	IL-4	47,51	STAT6	89,94	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	injury|nmod|START_ENTITY injury|dep|role role|nmod|END_ENTITY	Reduced hepatic_ischemia / reperfusion injury by IL-4 : potential anti-inflammatory role of STAT6 .
11164892	0	IL-4	0,4	STAT6	43,48	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|domain domain|compound|END_ENTITY	IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes .
11254707	0	IL-4	39,43	STAT6	0,5	IL-4	STAT6	3565	6778	Gene	Gene	fibroblasts|compound|START_ENTITY expression|nmod|fibroblasts mediates|dobj|expression mediates|nsubj|END_ENTITY	STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts .
11292026	0	IL-4	31,35	STAT6	12,17	IL-4	STAT6	3565	6778	Gene	Gene	production|compound|START_ENTITY role|nmod|production role|nmod|END_ENTITY	The role of STAT6 in mast cell IL-4 production .
11709700	0	IL-4	48,52	STAT6	102,107	IL-4	STAT6	3565	6778	Gene	Gene	alpha2-chain|nmod|START_ENTITY receptor|amod|alpha2-chain Induction|nmod|receptor Induction|dep|involvement involvement|nmod|pathways pathways|compound|ERK ERK|compound|END_ENTITY	Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes : involvement of STAT6 , ERK and p38 MAPK pathways .
11872954	0	IL-4	54,58	STAT6	28,33	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	cross-talk|nmod|START_ENTITY fishing|dep|cross-talk fishing|nmod|END_ENTITY	Oligonucleotide fishing for STAT6 : cross-talk between IL-4 and chemokines .
12121972	1	IL-4	81,85	STAT6	59,64	IL-4	STAT6	3565	6778	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|cycling cycling|nmod|END_ENTITY	Continuous cycling of STAT6 is required for IL-4 signaling .
12244176	0	IL-4	0,4	STAT6	53,58	IL-4	STAT6	3565	6778	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|processing processing|nmod|END_ENTITY	IL-4 induces the proteolytic processing of mast cell STAT6 .
12574343	0	IL-4	23,27	STAT6	126,131	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	regulate|compound|START_ENTITY found|nsubj|regulate found|nmod|END_ENTITY	The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism .
12960353	0	IL-4	16,20	STAT6	21,26	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Crucial role of IL-4 / STAT6 in T cell-mediated hepatitis : up-regulating eotaxins and IL-5 and recruiting leukocytes .
14978013	0	IL-4	70,74	STAT6	109,114	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY expression|nmod|ligation Induction|nmod|expression dependent|nsubj|Induction dependent|nmod|END_ENTITY	Induction of activation-induced_cytidine_deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB .
15004182	0	IL-4	0,4	STAT6	81,86	IL-4	STAT6	3565	6778	Gene	Gene	START_ENTITY|dep|requirement requirement|nmod|END_ENTITY	IL-4 and IL-13 up-regulate intestinal trefoil factor expression : requirement for STAT6 and de novo protein synthesis .
15620709	0	IL-4	68,72	STAT6	20,25	IL-4	STAT6	3565	6778	Gene	Gene	release|nmod|START_ENTITY release|dep|silencing silencing|nmod|siRNAs siRNAs|nummod|END_ENTITY	Gene silencing with STAT6 specific siRNAs blocks eotaxin release in IL-4 / TNFalpha stimulated human epithelial cells .
15661890	0	IL-4	80,84	STAT6	21,26	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY inhibiting|nmod|receptor END_ENTITY|advcl|inhibiting	IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor .
15922518	0	IL-4	41,45	STAT6	92,97	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY Induction|nmod|transcription requires|nsubj|Induction requires|dobj|element element|nmod|END_ENTITY	Induction of arginase_I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta .
16393965	0	IL-4	76,80	STAT6	47,52	IL-4	STAT6	3565	6778	Gene	Gene	binding|nmod|START_ENTITY receptor|amod|binding END_ENTITY|nmod|receptor	Progesterone-induced_blocking_factor activates STAT6 via binding to a novel IL-4 receptor .
16810739	0	IL-4	0,4	STAT6	46,51	IL-4	STAT6	3565	6778	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|TARC/CCL17 TARC/CCL17|nmod|sites sites|compound|END_ENTITY	IL-4 induces expression of TARC/CCL17 via two STAT6 binding sites .
17276885	0	IL-4	117,121	STAT6	18,23	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulation|nmod|production receptors|nmod|regulation role|nmod|receptors phosphorylation|dep|role phosphorylation|nummod|END_ENTITY	Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion : role of H1 receptors in the regulation of IL-4 production .
17276885	0	IL-4	59,63	STAT6	18,23	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY effects|nmod|secretion phosphorylation|nmod|effects phosphorylation|nummod|END_ENTITY	Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion : role of H1 receptors in the regulation of IL-4 production .
17347574	0	IL-4	105,109	STAT6	24,29	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY requirements|nmod|functions implies|dobj|requirements implies|nsubj|phenotype phenotype|nmod|mice mice|nummod|END_ENTITY	Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions .
17347574	0	IL-4	105,109	STAT6	65,70	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY requirements|nmod|functions requirements|compound|END_ENTITY	Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions .
19419769	0	IL-4	0,4	STAT6	109,114	IL-4	STAT6	3565	6778	Gene	Gene	alters|nsubj|START_ENTITY alters|nmod|mechanisms mechanisms|amod|END_ENTITY	IL-4 alters expression patterns of storage components of vascular endothelial cell-specific granules through STAT6 - and SOCS-1-dependent mechanisms .
19488417	0	IL-4	0,4	STAT6	46,51	IL-4	STAT6	3565	6778	Gene	Gene	translocalization|compound|START_ENTITY translocalization|nmod|END_ENTITY	IL-4 independent nuclear translocalization of STAT6 in HeLa cells by entry of Toxoplasma_gondii .
19540524	0	IL-4	9,13	STAT6	33,38	IL-4	STAT6	3565	6778	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells .
20010912	0	IL-4	30,34	STAT6	35,40	IL-4	STAT6	3565	6778	Gene	Gene	requirements|nmod|START_ENTITY requirements|parataxis|signalling signalling|nsubj|END_ENTITY	Differential requirements for IL-4 / STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses .
20876453	0	IL-4	51,55	STAT6	0,5	IL-4	STAT6	3565	6778	Gene	Gene	activated|nmod|START_ENTITY signaling|dep|activated END_ENTITY|acl|signaling	STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr_virus-encoded protein LMP-1 in absence of EBNA-2 : implications for the type II EBV latent gene expression in Hodgkin_lymphoma .
20980261	0	IL-4	96,100	STAT6	101,106	IL-4	STAT6	3565	6778	Gene	Gene	mediated|nmod|START_ENTITY naive|ccomp|mediated signaling|amod|naive signaling|compound|END_ENTITY	Inhibition of suppressive T_cell_factor_1 -LRB- TCF-1 -RRB- isoforms in naive CD4 + T cells is mediated by IL-4 / STAT6 signaling .
21149710	0	IL-4	0,4	STAT6	5,10	IL-4	STAT6	3565	6778	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|axis axis|nummod|END_ENTITY	IL-4 / STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity .
21814192	0	IL-4	12,16	STAT6	0,5	IL-4	STAT6	3565	6778	Gene	Gene	stimulation|compound|START_ENTITY links|dobj|stimulation links|nsubj|END_ENTITY	STAT6 links IL-4 / IL-13 stimulation with pendrin expression in asthma and chronic_obstructive_pulmonary_disease .
22730821	0	IL-4	27,31	STAT6	32,37	IL-4	STAT6	100720403	100726686	Gene	Gene	expressions|nmod|START_ENTITY expressions|dep|END_ENTITY	-LSB- Histologic expressions of IL-4 / STAT6 in nasal mucosa of guinea_pig allergic_rhinitis models and effect of glucocorticoid on them -RSB- .
26388667	0	IL-4	147,151	STAT6	152,157	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Wogonin , a plant flavone from Scutellariae radix , attenuated ovalbumin-induced airway_inflammation in mouse model of asthma via the suppression of IL-4 / STAT6 signaling .
26388667	0	IL-4	147,151	STAT6	152,157	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Wogonin , a plant flavone from Scutellariae radix , attenuated ovalbumin-induced airway_inflammation in mouse model of asthma via the suppression of IL-4 / STAT6 signaling .
26781462	0	IL-4	37,41	STAT6	48,53	IL-4	STAT6	3565	6778	Gene	Gene	expression|nmod|START_ENTITY changes|nmod|expression Analysis|nmod|changes END_ENTITY|nsubj|Analysis	Analysis of changes in expression of IL-4 / IL-13 / STAT6 pathway and correlation with the selected clinical parameters in patients with atopic_asthma .
26993600	0	IL-4	35,39	STAT6	75,80	IL-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY suppressive|dobj|effect suppressive|nmod|activation activation|nmod|END_ENTITY	Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Ra overexpressed_melanoma models .
9618271	0	IL-4	53,57	STAT6	97,102	IL-4	STAT6	3565	6778	Gene	Gene	receptor|compound|START_ENTITY portions|nmod|receptor Identification|nmod|portions alpha|nsubj|Identification alpha|nmod|activation activation|nmod|END_ENTITY	Identification of the critical portions of the human IL-4 receptor alpha chain for activation of STAT6 .
9686563	0	IL-4	66,70	STAT6	31,36	IL-4	STAT6	3565	6778	Gene	Gene	effects|nmod|START_ENTITY mimic|dobj|effects mimic|nsubj|form form|nmod|END_ENTITY	A conditionally active form of STAT6 can mimic certain effects of IL-4 .
26188063	0	IL-4	69,73	Stat3	48,53	IL-4	Stat3	16189(Tax:10090)	20848(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells .
10549628	0	IL-4	95,99	Stat6	100,105	IL-4	Stat6	3565	6778	Gene	Gene	using|dobj|START_ENTITY protect|xcomp|using T|acl:relcl|protect T|dep|END_ENTITY	Autoreactive CD4 + T cells protect from autoimmune diabetes via bystander suppression using the IL-4 / Stat6 pathway .
10679064	0	IL-4	28,32	Stat6	0,5	IL-4	Stat6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY regulation|nmod|responses regulation|amod|END_ENTITY	Stat6 regulation of in vivo IL-4 responses .
11390477	0	IL-4	38,42	Stat6	0,5	IL-4	Stat6	3565	6778	Gene	Gene	role|nmod:poss|START_ENTITY necessary|nmod|role necessary|nsubj|END_ENTITY	Stat6 is necessary and sufficient for IL-4 's role in Th2 differentiation and cell expansion .
11739727	0	IL-4	44,48	Stat6	0,5	IL-4	Stat6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	interleukin_4|appos|START_ENTITY cooperate|nmod|interleukin_4 cooperate|nsubj|END_ENTITY	Stat6 and IRS-2 cooperate in interleukin_4 -LRB- IL-4 -RRB- - induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis .
12847266	0	IL-4	14,18	Stat6	118,123	IL-4	Stat6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	Dependence|nmod|START_ENTITY Dependence|nmod|contractility contractility|nmod|nerves nerves|amod|END_ENTITY	Dependence of IL-4 , IL-13 , and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves .
12902491	0	IL-4	19,23	Stat6	75,80	IL-4	Stat6	3565	6778	Gene	Gene	receptor|compound|START_ENTITY programming|nmod|receptor signal|nsubj|programming signal|parataxis|mediated mediated|nsubj|induction induction|amod|END_ENTITY	New programming of IL-4 receptor signal transduction in activated T cells : Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines .
16298365	0	IL-4	0,4	Stat6	98,103	IL-4	Stat6	3565	6778	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	IL-4 modulates the histamine content of mast cells in a mast cell/fibroblast co-culture through a Stat6 signaling pathway in fibroblasts .
18292582	0	IL-4	0,4	Stat6	111,116	IL-4	Stat6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	determinant|nsubj|START_ENTITY determinant|nmod|generation generation|nmod|allergic_inflammation allergic_inflammation|acl|initiated initiated|nmod|END_ENTITY	IL-4 is a critical determinant in the generation of allergic_inflammation initiated by a constitutively active Stat6 .
18294957	0	IL-4	0,4	Stat6	5,10	IL-4	Stat6	3565	6778	Gene	Gene	START_ENTITY|appos|correlate correlate|nsubj|activities activities|amod|END_ENTITY	IL-4 / Stat6 activities correlate with apoptosis and metastasis in colon_cancer cells .
18536936	0	IL-4	13,17	Stat6	18,23	IL-4	Stat6	3565	6778	Gene	Gene	START_ENTITY|parataxis|correlate correlate|nsubj|activities activities|amod|END_ENTITY	Differential IL-4 / Stat6 activities correlate with differential expression of regulatory genes SOCS-1 , SHP-1 , and PP2A in colon_cancer cells .
7760829	0	IL-4	104,108	Stat6	18,23	IL-4	Stat6	3565	20852(Tax:10090)	Gene	Gene	phosphorylated|nmod|START_ENTITY phosphorylated|advcl|Cloning Cloning|nmod|END_ENTITY	Cloning of murine Stat6 and human Stat6 , Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis .
8602263	0	IL-4	27,31	Stat6	18,23	IL-4	Stat6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY role|nmod|signalling role|nmod|END_ENTITY	Essential role of Stat6 in IL-4 signalling .
8624821	0	IL-4	45,49	Stat6	0,5	IL-4	Stat6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	mediating|nmod|START_ENTITY required|advcl|mediating required|nsubjpass|END_ENTITY	Stat6 is required for mediating responses to IL-4 and for development of Th2 cells .
11807773	0	IL-4	155,159	TCR	129,132	IL-4	TCR	16189(Tax:10090)	328483(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	IL-15 induces type 1 and type 2 CD4 + and CD8 + T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro .
16818755	0	IL-4	117,121	TCR	32,35	IL-4	TCR	3565	6962	Gene	Gene	production|nmod|START_ENTITY down-regulation|nmod|production coreceptor|dep|down-regulation coreceptor|acl|improve improve|dobj|transfer transfer|compound|END_ENTITY	CD8_alpha coreceptor to improve TCR gene transfer to treat melanoma : down-regulation of tumor-specific production of IL-4 , IL-5 , and IL-10 .
9886391	0	IL-4	0,4	TCR	74,77	IL-4	TCR	16189(Tax:10090)	328483(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|cells cells|nmod|absence absence|nmod|engagement engagement|compound|END_ENTITY	IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement .
7955537	0	IL-4	46,50	TGF-beta	88,96	IL-4	TGF-beta	287287(Tax:10116)	59086(Tax:10116)	Gene	Gene	factor-beta|compound|START_ENTITY factor-beta|appos|END_ENTITY	Cellular mRNA expression of interferon-gamma , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental_allergic_neuritis .
9637480	0	IL-4	93,97	TGF-beta	141,149	IL-4	TGF-beta	16189(Tax:10090)	21803(Tax:10090)	Gene	Gene	have|nsubj|START_ENTITY have|advcl|regulates regulates|nsubj|END_ENTITY	Factors involved in the differentiation of TGF-beta-producing cells from naive CD4 + T cells : IL-4 and IFN-gamma have opposing effects , while TGF-beta positively regulates its own production .
9794401	0	IL-4	0,4	TGF-beta	25,33	IL-4	TGF-beta	16189(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	IL-4 in combination with TGF-beta favors an alternative pathway of Th1 development independent of IL-12 .
18475727	0	IL-4	43,47	TGFbeta	63,70	IL-4	TGFbeta	3565	7040	Gene	Gene	IL-13|compound|START_ENTITY IL-13|dep|END_ENTITY	Regulation by anti-inflammatory cytokines -LRB- IL-4 , IL-10 , IL-13 , TGFbeta -RRB- of interleukin-8 production by LPS - and / or TNFalpha-activated human polymorphonuclear cells .
2136902	0	IL-4	124,128	TH1	67,70	IL-4	TH1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	restored|nmod|START_ENTITY secrete|parataxis|restored secrete|nmod|cells cells|nummod|END_ENTITY	Antigen-specific sIalo B cells do not secrete IgG2a in response to TH1 cells and antigen : responsiveness can be restored by IL-4 .
12149469	0	IL-4	108,112	TH2	3,6	IL-4	TH2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	production|compound|START_ENTITY probabilities|nmod|production associated|nmod|probabilities states|acl|associated series|nmod|states has|dobj|series has|nmod|cells cells|nummod|END_ENTITY	In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production .
8174178	0	IL-4	54,58	TH2	34,37	IL-4	TH2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|release release|nmod|cytokines cytokines|compound|END_ENTITY	Regulation of in vitro release of TH2 type cytokines -LRB- IL-4 , IL-6 -RRB- in the T cell response to the trinitrophenyl -LRB- TNP -RRB- hapten .
20798517	0	IL-4	28,32	TNF	0,3	IL-4	TNF	16189(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	TNF increases expression of IL-4 and PARs in mast cells .
10227996	0	IL-4	0,4	TNF-alpha	32,41	IL-4	TNF-alpha	3565	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	IL-4 inhibits the production of TNF-alpha and IL-12 by STAT6-dependent and - independent mechanisms .
10233853	0	IL-4	133,137	TNF-alpha	96,105	IL-4	TNF-alpha	3565	7124	Gene	Gene	achieved|nmod|START_ENTITY achieved|nmod|END_ENTITY	Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability .
10460779	0	IL-4	0,4	TNF-alpha	47,56	IL-4	TNF-alpha	3565	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|acl|induced induced|nmod|END_ENTITY	IL-4 regulates chemokine production induced by TNF-alpha in keratocytes and corneal epithelial cells .
12441140	0	IL-4	0,4	TNF-alpha	152,161	IL-4	TNF-alpha	3565	7124	Gene	Gene	modulates|nsubj|START_ENTITY modulates|ccomp|CXCL10 CXCL10|nmod|END_ENTITY	IL-4 , but not IL-13 , modulates TARC -LRB- thymus_and_activation-regulated_chemokine -RRB- / CCL17 and IP-10 -LRB- interferon-induced_protein_of_10kDA -RRB- / CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line .
12569762	0	IL-4	14,18	TNF-alpha	40,49	IL-4	TNF-alpha	3565	7124	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Influence of IL-4 on the expression of TNF-alpha and IL-1_alpha mRNA by PBMCs from patients with subfulminant viral_hepatitis before and after treatment -RSB- .
12670721	0	IL-4	5,9	TNF-alpha	32,41	IL-4	TNF-alpha	3565	7124	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|ccomp|enhanced enhanced|nsubj|END_ENTITY	Both IL-4 and IL-13 inhibit the TNF-alpha and IFN-gamma enhanced MDC production in a human keratinocyte cell line , HaCaT cells .
12954239	0	IL-4	94,98	TNF-alpha	49,58	IL-4	TNF-alpha	280824(Tax:9913)	280943(Tax:9913)	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|IL-1_alpha IL-1_alpha|dep|IFN-gamma IFN-gamma|compound|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
14971043	0	IL-4	58,62	TNF-alpha	109,118	IL-4	TNF-alpha	16189(Tax:10090)	21926(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY mice|nmod|genes Pulmonary_tuberculosis|nmod|mice Pulmonary_tuberculosis|dep|changes changes|nmod|effects effects|nmod|END_ENTITY	Pulmonary_tuberculosis in BALB/c mice with non-functional IL-4 genes : changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis .
16513426	0	IL-4	52,56	TNF-alpha	41,50	IL-4	TNF-alpha	3565	7124	Gene	Gene	IL-5|appos|START_ENTITY IL-5|appos|END_ENTITY	Evaluation of cytokines -LRB- MIG , IFN-gamma , TNF-alpha , IL-4 , IL-5 , and IL-10 -RRB- during the different evolutive phases of chagasic esophagopathy .
16810557	0	IL-4	0,4	TNF-alpha	18,27	IL-4	TNF-alpha	3565	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|amod|END_ENTITY	IL-4 inhibits the TNF-alpha induced proliferation of renal_cell_carcinoma -LRB- RCC -RRB- and cooperates with TNF-alpha to induce apoptotic and cytokine responses by RCC : implications for antitumor immune responses .
17617590	0	IL-4	0,4	TNF-alpha	35,44	IL-4	TNF-alpha	3565	7124	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	IL-4 and IL-13 negatively regulate TNF-alpha - and IFN-gamma-induced beta-defensin expression through STAT-6 , suppressor_of_cytokine_signaling _ -LRB- SOCS -RRB- -1 , and SOCS-3 .
19521071	0	IL-4	64,68	TNF-alpha	52,61	IL-4	TNF-alpha	3565	7124	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Global gene analysis of Erigeron canadensis-treated TNF-alpha - , IL-4 - and IL-1beta-stimulated A549 human epithelial cells .
2113430	0	IL-4	32,36	TNF-alpha	0,9	IL-4	TNF-alpha	3565	7124	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	TNF-alpha and IFN-gamma reverse IL-4 inhibition of lymphokine-activated killer cell function .
2118480	0	IL-4	46,50	TNF-alpha	69,78	IL-4	TNF-alpha	16189(Tax:10090)	21926(Tax:10090)	Gene	Gene	Priming|nmod|START_ENTITY enhancement|dep|Priming enhancement|nmod|END_ENTITY	Priming the macrophage respiratory burst with IL-4 : enhancement with TNF-alpha but inhibition by IFN-gamma .
8742066	0	IL-4	0,4	TNF-alpha	104,113	IL-4	TNF-alpha	3565	7124	Gene	Gene	have|nsubj|START_ENTITY have|nmod|changes changes|nmod|release release|compound|END_ENTITY	IL-4 , IL-10 and IFN-gamma have distinct , but interacting , effects on differentiation-induced changes in TNF-alpha and TNF receptor release by cultured human monocytes .
9486409	0	IL-4	156,160	TNF-alpha	83,92	IL-4	TNF-alpha	16189(Tax:10090)	21926(Tax:10090)	Gene	Gene	secrete|dobj|START_ENTITY engineered|xcomp|secrete cells|acl|engineered treatment|nmod|cells transgenic_mice|nmod|treatment factor-alpha|amod|transgenic_mice factor-alpha|appos|END_ENTITY	Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- - transgenic_mice by treatment with cells engineered to secrete IL-4 , IL-10 or IL-13 .
9776110	0	IL-4	81,85	TNF-alpha	27,36	IL-4	TNF-alpha	3565	7124	Gene	Gene	IL-2|dep|START_ENTITY pro-inflammatory|appos|IL-2 pro-inflammatory|appos|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
10504438	0	IL-4	0,4	TNF_receptor_II	84,99	IL-4	TNF receptor II	3565	7133	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	IL-4 inhibits the migration of human Langerhans cells through the downregulation of TNF_receptor_II expression .
11536160	0	IL-4	48,52	Tax	35,38	IL-4	Tax	3565	6900	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Human T_cell_leukemia virus type I Tax enhances IL-4 gene expression in T cells .
10878379	0	IL-4	84,88	Th1	52,55	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Helicobacter_pylori-induced mucosal_inflammation is Th1 mediated and exacerbated in IL-4 , but not IFN-gamma , gene-deficient mice .
11160346	0	IL-4	0,4	Th1	30,33	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	exacerbates|nsubj|START_ENTITY exacerbates|nmod|model model|amod|END_ENTITY	IL-4 exacerbates disease in a Th1 cell transfer model of colitis .
12055229	0	IL-4	124,128	Th1	21,24	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY preventing|dobj|effects regulates|nmod|preventing Role|parataxis|regulates Role|nmod|differentiation differentiation|amod|END_ENTITY	Role of IFN-gamma in Th1 differentiation : IFN-gamma regulates IL-18R_alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression .
12244163	0	IL-4	8,12	Th1	44,47	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	correlates|compound|START_ENTITY correlates|nmod|END_ENTITY	Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity_pneumonitis in two inbred strains of mice .
12444170	0	IL-4	47,51	Th1	28,31	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	IFN-gamma|dep|START_ENTITY Th2|appos|IFN-gamma END_ENTITY|dep|Th2	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
1401925	0	IL-4	0,4	Th1	110,113	IL-4	Th1	3565	51497	Gene	Gene	exert|nsubj|START_ENTITY exert|nmod|END_ENTITY	IL-4 and IFN -LRB- alpha and gamma -RRB- exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones .
15084272	0	IL-4	0,4	Th1	60,63	IL-4	Th1	3565	51497	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|receptor receptor|acl|drive drive|dobj|apoptosis apoptosis|nmod|cells cells|amod|END_ENTITY	IL-4 utilizes an alternative receptor to drive apoptosis of Th1 cells and skews neonatal immunity toward Th2 .
1534825	0	IL-4	0,4	Th1	71,74	IL-4	Th1	3565	51497	Gene	Gene	plays|nsubj|START_ENTITY plays|nmod|cells cells|amod|END_ENTITY	IL-4 plays a dominant role in the differential development of Tho into Th1 and Th2 cells .
17199110	0	IL-4	191,195	Th1	135,138	IL-4	Th1	3565	51497	Gene	Gene	effective|nmod|START_ENTITY effective|nsubj|selection selection|dep|inhibition inhibition|nmod|cells cells|amod|END_ENTITY	3D computation modelling of the influence of cytokine secretion on Th-cell development suggests that negative selection -LRB- inhibition of Th1 cells -RRB- is more effective than positive selection by IL-4 for Th2 cell dominance .
19752754	0	IL-4	0,4	Th1	81,84	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|acl:relcl|required required|nmod|trafficking trafficking|compound|END_ENTITY	IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors .
21572032	0	IL-4	30,34	Th1	76,79	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	producing|dobj|START_ENTITY cells|acl|producing inhibit|nsubj|cells inhibit|dobj|response response|amod|END_ENTITY	Invariant NKT cells producing IL-4 or IL-10 , but not IFN-gamma , inhibit the Th1 response in experimental autoimmune encephalomyelitis , whereas none of these cells inhibits the Th17 response .
22464042	0	IL-4	25,29	Th1	94,97	IL-4	Th1	3565	51497	Gene	Gene	levels|compound|START_ENTITY levels|dep|reason reason|nmod|incidence incidence|nmod|diseases diseases|amod|END_ENTITY	Possible different serum IL-4 levels across populations : a reason for dissimilar incidence of Th1 and Th2 diseases .
22504655	0	IL-4	97,101	Th1	36,39	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Identification Identification|nmod|pathway pathway|nmod|development development|amod|END_ENTITY	Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGF-b .
24120849	0	IL-4	106,110	Th1	67,70	IL-4	Th1	3565	51497	Gene	Gene	cytokines|appos|START_ENTITY _|dobj|cytokines _|nsubj|analysis analysis|nmod|END_ENTITY	Cloning and sequence analysis of Peromyscus yucatanicus -LRB- Rodentia -RRB- Th1 -LRB- IL-12p35 , IFN-y_and_TNF -RRB- _ and_Th2 -LRB- IL-4 , IL-10 and TGF-b -RRB- cytokines .
7541410	0	IL-4	107,111	Th1	167,170	IL-4	Th1	3565	51497	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nmod|clones clones|amod|END_ENTITY	Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones .
8799723	0	IL-4	38,42	Th1	96,99	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY Leishmania_major|nmod|transgenic_mice Susceptibility|nmod|Leishmania_major correlated|nsubjpass|Susceptibility correlated|nmod|lack lack|nmod|response response|amod|END_ENTITY	Susceptibility to Leishmania_major in IL-4 transgenic_mice is not correlated with the lack of a Th1 immune response .
9794401	0	IL-4	0,4	Th1	67,70	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	favors|nsubj|START_ENTITY favors|dobj|pathway pathway|nmod|independent independent|amod|END_ENTITY	IL-4 in combination with TGF-beta favors an alternative pathway of Th1 development independent of IL-12 .
9973471	0	IL-4	108,112	Th1	41,44	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY Th1|acl|induced effects|nmod|Th1 Evidence|dep|effects Evidence|nmod|cross-regulation cross-regulation|nmod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
9973471	0	IL-4	108,112	Th1	93,96	IL-4	Th1	16189(Tax:10090)	57314(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
10064056	0	IL-4	26,30	Th2	52,55	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nmod|cells cells|amod|END_ENTITY	Lipid_A directly inhibits IL-4 production by murine Th2 cells but does not inhibit IFN-gamma production by Th1 cells .
10415077	0	IL-4	11,15	Th2	53,56	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY results|nsubj|expression results|nmod|cells cells|amod|END_ENTITY	Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse .
10429761	0	IL-4	40,44	Th2	20,23	IL-4	Th2	3565	15111(Tax:10090)	Gene	Gene	IL-3|appos|START_ENTITY IL-3|amod|END_ENTITY	Localization of the Th2 cytokines IL-3 , IL-4 , IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy .
10706693	0	IL-4	34,38	Th2	147,150	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	receptor/Stat6|compound|START_ENTITY required|nsubjpass|receptor/Stat6 required|nmod|profile profile|amod|END_ENTITY	Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4 + lymphocytes with a Th2 cytokine profile .
10725711	0	IL-4	0,4	Th2	73,76	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cell cell|amod|END_ENTITY	IL-4 , IL-10 , IL-13 , and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis .
10727445	0	IL-4	103,107	Th2	0,3	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|responses responses|amod|END_ENTITY	Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4 .
10975806	0	IL-4	29,33	Th2	71,74	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	cytokine|dep|START_ENTITY cluster|amod|cytokine cluster|nmod|clones clones|amod|END_ENTITY	Coordinate regulation of the IL-4 , IL-13 , and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns .
11034364	0	IL-4	62,66	Th2	74,77	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	source|nmod|START_ENTITY provide|dobj|source provide|nmod|differentiation differentiation|amod|END_ENTITY	Conventional , naive CD4 + T cells provide an initial source of IL-4 during Th2 differentiation .
11465116	0	IL-4	87,91	Th2	112,115	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Reversal of established delayed type hypersensitivity_reactions following therapy with IL-4 or antigen-specific Th2 cells .
11981831	0	IL-4	0,4	Th2	87,90	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	secreted|nsubj|START_ENTITY secreted|xcomp|induce induce|dobj|differentiation differentiation|amod|END_ENTITY	IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation .
12150887	0	IL-4	0,4	Th2	28,31	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|responses responses|amod|END_ENTITY	IL-4 induces characteristic Th2 responses even in the combined absence of IL-5 , IL-9 , and IL-13 .
12218103	0	IL-4	70,74	Th2	0,3	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	IL-13|compound|START_ENTITY absence|nmod|IL-13 priming|nmod|absence cell|acl|priming induced|nmod|cell induced|nsubj|activities activities|amod|END_ENTITY	Th2 activities induced during virgin T cell priming in the absence of IL-4 , IL-13 , and B cells .
12444170	0	IL-4	47,51	Th2	32,35	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	IFN-gamma|dep|START_ENTITY END_ENTITY|appos|IFN-gamma	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12646613	0	IL-4	78,82	Th2	86,89	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|appos|cytokine cytokine|amod|END_ENTITY	Prevention of autoantibody-mediated Graves ' - like hyperthyroidism in mice with IL-4 , a Th2 cytokine .
14500651	0	IL-4	85,89	Th2	71,74	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	cytokines|dobj|START_ENTITY cytokines|nsubj|Induction Induction|nmod|expression expression|nmod|END_ENTITY	Induction of macrophage insulin-like_growth_factor-I expression by the Th2 cytokines IL-4 and IL-13 .
14646385	0	IL-4	21,25	Th2	40,43	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nmod|cells cells|amod|END_ENTITY	Bisphenol_A promotes IL-4 production by Th2 cells .
14764670	0	IL-4	0,4	Th2	46,49	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|differentiation differentiation|nmod|eosinophils eosinophils|amod|END_ENTITY	IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils .
1531351	0	IL-4	0,4	Th2	15,18	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|response response|amod|END_ENTITY	IL-4 induces a Th2 response in Leishmania_major-infected mice .
15699158	0	IL-4	19,23	Th2	74,77	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	drive|nsubj|START_ENTITY drive|dobj|development development|nmod|cells cells|amod|END_ENTITY	IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites .
15712252	0	IL-4	73,77	Th2	92,95	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY engineered|xcomp|express production|amod|engineered production|dep|induction induction|nmod|responses responses|amod|END_ENTITY	Cytokine production by dendritic cells genetically engineered to express IL-4 : induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis .
16237061	0	IL-4	88,92	Th2	74,77	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	cytokines|dobj|START_ENTITY cytokines|nsubj|Induction Induction|nmod|expression expression|nmod|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- gene expression by the Th2 cytokines IL-4 and IL-13 .
18719110	0	IL-4	42,46	Th2	69,72	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY reveal|dobj|role reveal|xcomp|signaling signaling|nmod|differentiation differentiation|amod|END_ENTITY	In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation .
18768853	0	IL-4	69,73	Th2	21,24	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY induce|dobj|transcription activates|xcomp|induce activates|nsubj|calcium calcium|nmod|cells cells|amod|END_ENTITY	Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization .
19201853	0	IL-4	118,122	Th2	134,137	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	produce|iobj|START_ENTITY produce|nmod|cells cells|compound|END_ENTITY	Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4 / 13 , unlike Th2 and NKT cells .
19891612	0	IL-4	0,4	Th2	67,70	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|dep|cytokines cytokines|amod|END_ENTITY	IL-4 -LRB- - / - -RRB- mice with lethal Mesocestoides corti infections -- reduced Th2 cytokines and alternatively activated macrophages .
21131429	0	IL-4	41,45	Th2	15,18	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibiting|dobj|production skewing|advcl|inhibiting END_ENTITY|acl|skewing	SHIP represses Th2 skewing by inhibiting IL-4 production from basophils .
23195129	9	IL-4	1468,1472	Th2	1454,1457	TARC	Th2	20295(Tax:10090)	15111(Tax:10090)	Gene	Gene	cytokines|dobj|START_ENTITY cytokines|nsubj|END_ENTITY	COE significantly inhibited serum total IgE ; Th2 cytokines IL-4 , IL-5 and IL-13 ; pro-inflammatory cytokines IL-1b , IL6 and TNF-a ; the Th2 chemokine TARC and the pro-Th2 cytokine TSLP .
23743163	0	IL-4	81,85	Th2	115,118	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibit|dobj|secretion inhibit|nmod|cells cells|amod|END_ENTITY	Constituents of the anti-asthma herbal formula ASHMI -LRB- TM -RRB- synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells , and eotaxin by human lung fibroblasts in vitro .
8384701	0	IL-4	25,29	Th2	42,45	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Disruption|nmod|gene blocks|nsubj|Disruption blocks|dobj|responses responses|amod|END_ENTITY	Disruption of the murine IL-4 gene blocks Th2 cytokine responses .
8613355	0	IL-4	36,40	Th2	128,131	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	interleukin-4|appos|START_ENTITY immunization|nmod|interleukin-4 reveals|nsubj|immunization reveals|ccomp|associated associated|nsubjpass|cells cells|amod|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8906817	0	IL-4	20,24	Th2	42,45	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4 + NK1 .1 - T cell population .
9973471	0	IL-4	108,112	Th2	48,51	IL-4	Th2	16189(Tax:10090)	15111(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY Th1|acl|induced effects|nmod|Th1 Evidence|dep|effects Evidence|nmod|cross-regulation cross-regulation|nmod|Th1 Th1|nmod|cells cells|amod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
1973079	0	IL-4	48,52	Thy-1	28,33	IL-4	Thy-1	16189(Tax:10090)	21838(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of murine B cell Thy-1 expression by IL-4 , IFN-gamma , and CD4 + T cell subsets .
7495757	0	IL-4	73,77	Thy-1	36,41	IL-4	Thy-1	16189(Tax:10090)	21838(Tax:10090)	Gene	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Positive and negative regulation of Thy-1 expression on B lymphocytes by IL-4 .
19157556	0	IL-4	37,41	Toll-like_receptor_7	0,20	IL-4	Toll-like receptor 7	16189(Tax:10090)	170743(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Toll-like_receptor_7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production .
8186198	0	IL-4	41,45	Transforming_growth_factor-beta	0,31	IL-4	Transforming growth factor-beta	3565	7040	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits IL-4 and IFN-gamma production by stimulated human T cells .
19703147	0	IL-4	20,24	Urocortin	0,9	IL-4	Urocortin	3565	7349	Gene	Gene	secretion|compound|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells .
10233853	0	IL-4	133,137	VCAM-1	29,35	IL-4	VCAM-1	3565	7412	Gene	Gene	achieved|nmod|START_ENTITY achieved|nsubjpass|levels levels|nmod|END_ENTITY	Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability .
10946314	0	IL-4	61,65	VCAM-1	24,30	IL-4	VCAM-1	287287(Tax:10116)	25361(Tax:10116)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|activity activity|nmod|END_ENTITY	The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13 .
7533184	0	IL-4	0,4	VCAM-1	18,24	IL-4	VCAM-1	3565	7412	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	IL-4 induction of VCAM-1 on endothelial cells involves activation of a protein tyrosine kinase .
10783149	0	IL-4	0,4	VIP_receptor_subtype_2	15,37	IL-4	VIP receptor subtype 2	16189(Tax:10090)	22355(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-4 regulates VIP_receptor_subtype_2 mRNA -LRB- VPAC2 -RRB- expression in T cells in murine schistosomiasis .
26040016	0	IL-4	105,109	YKL-40	21,27	IL-4	YKL-40	3565	1116	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of serum YKL-40 in anaphylactic rhinitis patients and association of serum YKL-40 with serum IL-4 and IFN-y -RSB- .
9344865	1	IL-4	314,318	alpha-chain	206,217	IL-4	alpha-chain	3565	2217	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of ligand binding to soluble IL-4 receptor alpha-chain by surface plasmon resonance measurements and by microtiter-plate-based ELISA with biotinylated IL-4 .
15922518	0	IL-4	41,45	arginase_I	13,23	IL-4	arginase I	16189(Tax:10090)	11846(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Induction of arginase_I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta .
17393183	0	IL-4	51,55	beta-defensin-2	27,42	IL-4	beta-defensin-2	100860814	100861169	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Downregulation of the goat beta-defensin-2 gene by IL-4 in caprine intestinal epithelial cells infected with Eimeria spp .
15832295	0	IL-4	100,104	c-Maf	79,84	IL-4	c-Maf	16189(Tax:10090)	17132(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Impaired IL-4 production by CD8 + T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter .
15832295	0	IL-4	9,13	c-Maf	79,84	IL-4	c-Maf	16189(Tax:10090)	17132(Tax:10090)	Gene	Gene	production|compound|START_ENTITY related|nsubjpass|production related|nmod|defect defect|nmod|END_ENTITY	Impaired IL-4 production by CD8 + T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter .
19553542	0	IL-4	115,119	c-Maf	90,95	IL-4	c-Maf	16189(Tax:10090)	17132(Tax:10090)	Gene	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4 .
22798672	0	IL-4	61,65	c-Maf	28,33	IL-4	c-Maf	3565	4094	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene enhances|dobj|expression enhances|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene .
24821970	0	IL-4	40,44	c-Maf	22,27	IL-4	c-Maf	16189(Tax:10090)	17132(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression END_ENTITY|xcomp|regulate	KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4 + T cells .
1721642	0	IL-4	0,4	c-kit	15,20	IL-4	c-kit	3565	3815	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IL-4 regulates c-kit proto-oncogene product expression in human mast and myeloid progenitor cells .
10438901	0	IL-4	14,18	c-maf	61,66	IL-4	c-maf	3565	4094	Gene	Gene	production|compound|START_ENTITY require|nsubj|production require|xcomp|END_ENTITY	Cutting edge : IL-4 production by mast cells does not require c-maf .
14688382	0	IL-4	27,31	c-maf	45,50	IL-4	c-maf	3565	4094	Gene	Gene	induction|compound|START_ENTITY antagonizes|dobj|induction antagonizes|nmod|END_ENTITY	NF-kappa_B_p65 antagonizes IL-4 induction by c-maf in minimal change_nephrotic_syndrome .
16547273	0	IL-4	53,57	eotaxin	61,68	IL-4	eotaxin	16189(Tax:10090)	20292(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression : involvement of STAT6 .
15753898	0	IL-4	78,82	eotaxin-1	20,29	IL-4	eotaxin-1	3565	6356	Gene	Gene	synergy|nmod|START_ENTITY causes|parataxis|synergy causes|dobj|release release|amod|END_ENTITY	Oncostatin_M causes eotaxin-1 release from airway smooth muscle : synergy with IL-4 and IL-13 .
16237106	0	IL-4	0,4	formyl_peptide_receptor_2	38,63	IL-4	formyl peptide receptor 2	16189(Tax:10090)	14289(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	IL-4 inhibits the expression of mouse formyl_peptide_receptor_2 , a receptor for amyloid beta1-42 , in TNF-alpha-activated microglia .
9200485	0	IL-4	62,66	histamine-releasing_factor	12,38	IL-4	histamine-releasing factor	3565	7178	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Recombinant histamine-releasing_factor enhances IgE-dependent IL-4 and IL-13 secretion by human basophils .
8436904	0	IL-4	72,76	immunoglobulin_E_receptor	92,117	IL-4	immunoglobulin E receptor	3565	2206	Gene	Gene	produce|dobj|START_ENTITY produce|nmod|stimulation stimulation|compound|END_ENTITY	Human peripheral blood basophils primed by interleukin_3 _ -LRB- IL-3 -RRB- produce IL-4 in response to immunoglobulin_E_receptor stimulation .
10566657	0	IL-4	118,122	interferon-gamma	201,217	IL-4	interferon-gamma	3565	3458	Gene	Gene	increases|appos|START_ENTITY increases|nmod|increases increases|nmod|production production|amod|END_ENTITY	Effect of radioactive iodine therapy on cytokine production in Graves ' _ disease : transient increases in interleukin-4 -LRB- IL-4 -RRB- , IL-6 , IL-10 , and tumor_necrosis_factor-alpha , with longer term increases in interferon-gamma production .
1401997	0	IL-4	9,13	interferon-gamma	99,115	IL-4	interferon-gamma	3565	3458	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Enhanced IL-4 production and IL-4_receptor expression in atopic_dermatitis and their modulation by interferon-gamma .
1907531	0	IL-4	56,60	interferon-gamma	12,28	IL-4	interferon-gamma	3565	3458	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Recombinant interferon-gamma inhibits the expression of IL-4 receptors on human lymphocytes .
7542576	0	IL-4	96,100	interferon-gamma	66,82	IL-4	interferon-gamma	3565	3458	Gene	Gene	factor-beta|compound|START_ENTITY present|nsubj|factor-beta present|advcl|expressing expressing|dobj|END_ENTITY	High numbers of autoantigen-reactive mononuclear cells expressing interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- are present in cord blood .
9677601	0	IL-4	9,13	interferon-gamma	25,41	IL-4	interferon-gamma	3565	3458	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Enhanced IL-4 but normal interferon-gamma production in children with isolated IgE_mediated_food_hypersensitivity .
1830499	0	IL-4	86,90	interleukin-4	71,84	IL-4	interleukin-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 -LRB- IL-4 -RRB- , IL-5 , and gamma-interferon , but not IL-2 by activated murine T cells .
18662263	0	IL-4	52,56	interleukin-4	32,45	IL-4	interleukin-4	3565	3565	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	The -589 C > T polymorphism in the interleukin-4 gene -LRB- IL-4 -RRB- is associated with a reduced risk of myocardial_infarction in young individuals .
25986324	0	IL-4	21,25	interleukin-4	6,19	IL-4	interleukin-4	101122781	101122781	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Serum interleukin-4 -LRB- IL-4 -RRB- production is associated with lower fecal egg count in parasite-resistant sheep .
25986324	0	IL-4	21,25	interleukin-4	6,19	IL-4	interleukin-4	101122781	101122781	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Serum interleukin-4 -LRB- IL-4 -RRB- production is associated with lower fecal egg count in parasite-resistant sheep .
8440075	0	IL-4	37,41	interleukin-4	22,35	IL-4	interleukin-4	3565	3565	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Suppressive effect of interleukin-4 -LRB- IL-4 -RRB- on IL-6 production by adherent rheumatoid synovial cells .
9787171	0	IL-4	43,47	interleukin-4	28,41	IL-4	interleukin-4	3565	3565	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	OX40 costimulation enhances interleukin-4 -LRB- IL-4 -RRB- expression at priming and promotes the differentiation of naive human CD4 -LRB- + -RRB- T cells into high IL-4-producing effectors .
9743616	0	IL-4	31,35	interleukin-7_and_transforming_growth_factor-beta	84,133	IL-4	interleukin-7 and transforming growth factor-beta	3565	3574;7040	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of human lymphocyte IL-4 secretion by intestinal epithelial cell-derived interleukin-7_and_transforming_growth_factor-beta .
2060018	0	IL-4	36,40	interleukin_4	21,34	IL-4	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of murine interleukin_4 -LRB- IL-4 -RRB- receptor expression using anti-receptor monoclonal antibodies and S1 nuclease protection analyses .
7504061	0	IL-4	18,22	interleukin_4	3,16	IL-4	interleukin 4	3565	3565	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 -LRB- IgG4 -RRB- and IgE synthesis and B cell proliferation : support for a common component shared by IL-4 and IL-13 receptors .
7807002	0	IL-4	38,42	interleukin_4	23,36	IL-4	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Characterization of an interleukin_4 -LRB- IL-4 -RRB- responsive region in the immunoglobulin heavy chain germline epsilon promoter : regulation by NF-IL-4 , a C/EBP family member and NF-kappa_B / p50 .
8145047	0	IL-4	28,32	interleukin_4	13,26	IL-4	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin_4 -LRB- IL-4 -RRB- expression in T helper -LRB- Th -RRB- cells is not dependent on IL-4 from non-Th cells .
9380721	0	IL-4	60,64	interleukin_4	3,16	IL-4	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY revealed|nsubjpass|production independent|ccomp|revealed mice|amod|independent END_ENTITY|dep|mice	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
12734374	0	IL-4	85,89	monocyte_chemoattractant_protein-1	23,57	IL-4	monocyte chemoattractant protein-1	16189(Tax:10090)	20296(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	C-C_chemokine_ligand_2 / monocyte_chemoattractant_protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse .
12645940	0	IL-4	0,4	p40	21,24	IL-4	p40	3565	3578	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IL-4 regulates IL-12 p40 expression post-transcriptionally as well as via a promoter-based mechanism .
1888707	0	IL-4	0,4	p75	34,37	IL-4	p75	3565	3560	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	IL-4 down-regulates IL-2_receptor p75 by accelerating its endocytosis .
15163899	0	IL-4	14,18	paxillin	42,50	IL-4	paxillin	280824(Tax:9913)	517456(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells .
8870712	0	IL-4	13,17	platelet-activating_factor	21,47	IL-4	platelet-activating factor	3565	9768	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of IL-4 by platelet-activating_factor .
9514702	0	IL-4	100,104	retinal_S-antigen	57,74	IL-4	retinal S-antigen	287287(Tax:10116)	25539(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Regulatory cells generated by testicular tolerization to retinal_S-antigen : possible involvement of IL-4 , IL-10 , and TGF-beta in the suppression of experimental autoimmune uveoretinitis .
26627546	0	IL-4	30,34	sirtuin-1	10,19	IL-4	sirtuin-1	3565	23411	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma .
11823524	0	IL-4	0,4	tissue_inhibitor_of_metalloproteinase-2	36,75	IL-4	tissue inhibitor of metalloproteinase-2	3565	7077	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	IL-4 up-regulates the expression of tissue_inhibitor_of_metalloproteinase-2 in dermal fibroblasts via the p38_mitogen-activated_protein_kinase dependent pathway .
1653804	0	IL-4	0,4	transforming_growth_factor-beta	65,96	IL-4	transforming growth factor-beta	3565	7040	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	IL-4 antagonizes induction of Fc_gamma_RIII -LRB- CD16 -RRB- expression by transforming_growth_factor-beta on human monocytes .
7954438	0	IL-4	140,144	tumor_necrosis_factor_alpha	165,192	IL-4	tumor necrosis factor alpha	16189(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
10430178	0	IL-4	61,65	vascular_cell_adhesion_molecule-1	13,46	IL-4	vascular cell adhesion molecule-1	3565	7412	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of vascular_cell_adhesion_molecule-1 expression by IL-4 in human aortic smooth muscle cells is not associated with increased nuclear NF-kappaB levels .
1698865	0	IL-4	0,4	vascular_cell_adhesion_molecule-1	117,150	IL-4	vascular cell adhesion molecule-1	3565	7412	Gene	Gene	acts|nsubj|START_ENTITY acts|xcomp|promote promote|advcl|microvascular microvascular|nmod|induction induction|nmod|END_ENTITY	IL-4 acts synergistically with IL-1_beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular_cell_adhesion_molecule-1 .
7529260	0	IL-4	62,66	vascular_cell_adhesion_molecule-1	14,47	IL-4	vascular cell adhesion molecule-1	3565	7412	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of vascular_cell_adhesion_molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells .
8639787	0	IL-4	15,19	vascular_cell_adhesion_molecule-1	101,134	IL-4	vascular cell adhesion molecule-1	3565	7412	Gene	Gene	Interleukin-4|appos|START_ENTITY Interleukin-4|acl|mediating mediating|dobj|induction induction|amod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular_cell_adhesion_molecule-1 induction in the absence of the common_gamma_chain .
12102661	0	IL-4	0,4	vascular_endothelial_growth_factor	50,84	IL-4	vascular endothelial growth factor	3565	7422	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|release release|compound|END_ENTITY	IL-4 and interferon-gamma differentially modulate vascular_endothelial_growth_factor release from normal human keratinocytes and fibroblasts .
8548394	0	IL-4-R	106,112	IL-4	91,95	IL-4-R	IL-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Modulation of the immunoglobulin dysregulation in GvH - and SLE-like diseases by the murine IL-4 receptor -LRB- IL-4-R -RRB- .
9619370	0	IL-4R	46,51	interleukin_4_receptor	22,44	IL-4R	interleukin 4 receptor	3566	3566	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Function of the human interleukin_4_receptor -LRB- IL-4R -RRB- - derived acidic motif revealed by cytoplasmic domain chimeras of the IL-4R_alpha chain and the IL-2R_beta chain .
21245915	0	IL-4Ra	36,42	CD4	25,28	IL-4Ra	CD4	16190(Tax:10090)	12504(Tax:10090)	Gene	Gene	Load|compound|START_ENTITY Load|compound|END_ENTITY	BALB/c mice deficient in CD4 T cell IL-4Ra expression control Leishmania mexicana Load although female but not male mice develop a healer phenotype .
23543769	0	IL-4Ra	0,6	CD4	10,13	IL-4Ra	CD4	3566	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	IL-4Ra on CD4 + T cells plays a pathogenic role in respiratory_syncytial_virus reinfection in mice infected initially as neonates .
21210100	0	IL-4Ra	94,100	IL-13	77,82	IL-4Ra	IL-13	3566	3596	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Two copies of the genes encoding the subunits of putative interleukin -LRB- IL -RRB- -4 / IL-13 receptors , IL-4Ra , IL-13Ra1 and IL-13Ra2 , have been identified in rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- and have complex patterns of expression and modulation .
24979482	0	IL-4Ra	10,16	IL-13	4,9	IL-4Ra	IL-13	3566	3596	Gene	Gene	axis|compound|START_ENTITY involved|nsubjpass|axis END_ENTITY|parataxis|involved	The IL-13 / IL-4Ra axis is involved in tuberculosis-associated pathology .
24403255	0	IL-4Ra	33,39	IL-4	14,18	IL-4Ra	IL-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	IL-13 but not IL-4 signaling via IL-4Ra protects mice from papilloma formation during DMBA/TPA two-step skin_carcinogenesis .
24966389	0	IL-4Ra	158,164	IL-4	0,4	IL-4Ra	IL-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	consequences|nmod|START_ENTITY drives|parataxis|consequences drives|compound|END_ENTITY	IL-4 signaling drives a unique arginase + / IL-1b + microglia phenotype and recruits macrophages to the inflammatory CNS : consequences of age-related deficits in IL-4Ra after traumatic spinal_cord_injury .
26044177	0	IL-4Ra	70,76	IL-4	100,104	IL-4Ra	IL-4	3566	3565	Gene	Gene	Identification|appos|START_ENTITY Antagonist|nsubj|Identification Antagonist|nmod|Signalling Signalling|compound|END_ENTITY	Identification and Characterization of a Novel IL-4_Receptor_a_Chain -LRB- IL-4Ra -RRB- Antagonist to Inhibit IL-4 Signalling .
26993600	0	IL-4Ra	84,90	IL-4	35,39	IL-4Ra	IL-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	models|compound|START_ENTITY STAT6|nmod|models activation|nmod|STAT6 suppressive|nmod|activation suppressive|dobj|effect effect|nmod|END_ENTITY	Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Ra overexpressed_melanoma models .
15816016	0	IL-4Ralpha	0,10	CD4	81,84	IL-4Ralpha	CD4	3566	920	Gene	Gene	signaling|compound|START_ENTITY important|nsubj|signaling important|nmod|absence absence|nmod|help help|compound|END_ENTITY	IL-4Ralpha signaling is important for CD8 + T cell cytotoxicity in the absence of CD4 + T cell help .
17500591	0	IL-4Ralpha	12,22	CD4	26,29	IL-4Ralpha	CD4	16190(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania_major_infection .
9815258	0	IL-4Ralpha	69,79	IL-2Rbeta	58,67	IL-4Ralpha	IL-2Rbeta	16190(Tax:10090)	16185(Tax:10090)	Gene	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	In vivo function of an interleukin_2_receptor_beta_chain -LRB- IL-2Rbeta -RRB- / IL-4Ralpha cytokine receptor chimera potentiates allergic_airway_disease .
12902491	0	IL-4Ralpha	127,137	IL-4	19,23	IL-4Ralpha	IL-4	3566	3565	Gene	Gene	mediated|nmod|START_ENTITY signal|parataxis|mediated signal|nsubj|programming programming|nmod|receptor receptor|compound|END_ENTITY	New programming of IL-4 receptor signal transduction in activated T cells : Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines .
16503977	0	IL-4Ralpha	27,37	IL-4	0,4	IL-4Ralpha	IL-4	3566	3565	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|alpha alpha|dep|END_ENTITY	IL-4 alpha chain receptor -LRB- IL-4Ralpha -RRB- polymorphisms in allergic bronchopulmonary_sspergillosis .
17189592	0	IL-4Ralpha	0,10	IL-4	41,45	IL-4Ralpha	IL-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|regulation regulation|nmod|synthesis synthesis|compound|END_ENTITY	IL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells : implication in susceptibility to a subset of murine lupus .
18029018	0	IL-4Ralpha	49,59	IL-4	7,11	IL-4Ralpha	IL-4	3566	3565	Gene	Gene	signal|nmod|START_ENTITY able|xcomp|signal END_ENTITY|acl:relcl|able	Murine IL-4 is able to signal via chimeric human IL-4Ralpha / mouse gamma-chain receptor .
18198661	0	IL-4Ralpha	22,32	IL-4	16,20	IL-4Ralpha	IL-4	3566	3565	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Skeletal muscle IL-4 , IL-4Ralpha , IL-13 and IL-13Ralpha1 expression and response to strength training .
18852293	0	IL-4Ralpha	65,75	IL-4	22,26	IL-4Ralpha	IL-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|nsubj|expression Tuning|parataxis|regulates Tuning|nmod|END_ENTITY	Tuning sensitivity to IL-4 and IL-13 : differential expression of IL-4Ralpha , IL-13Ralpha1 , and gammac regulates relative cytokine sensitivity .
19799897	0	IL-4Ralpha	131,141	IL-4	110,114	IL-4Ralpha	IL-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	chains|amod|START_ENTITY chains|compound|END_ENTITY	Oncostatin_M -LRB- OSM -RRB- primes IL-13 - _ and_IL-4-induced eotaxin responses in fibroblasts : regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1 .
8390454	0	IL-4_receptor	69,82	HT2	177,180	IL-4 receptor	HT2	16190(Tax:10090)	109524(Tax:10090)	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
24742632	0	IL-4_receptor	58,71	IL-4	53,57	IL-4 receptor	IL-4	3566	3565	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association between genes encoding components of the IL-4 / IL-4_receptor pathway and dermatitis in children .
8390454	0	IL-4_receptor	139,152	Interleukin-4	0,13	IL-4 receptor	Interleukin-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	3-kinase|nmod|START_ENTITY line|amod|3-kinase IL-4_receptor|nmod|line phosphorylation|nmod|IL-4_receptor induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
8390454	0	IL-4_receptor	69,82	Interleukin-4	0,13	IL-4 receptor	Interleukin-4	16190(Tax:10090)	16189(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
11694459	0	IL-4_receptor-alpha_chain	60,85	IL-5	114,118	IL-4 receptor-alpha chain	IL-5	16190(Tax:10090)	16191(Tax:10090)	Gene	Gene	independently|amod|START_ENTITY independently|nmod|END_ENTITY	Interleukin-13 mediates airways_hyperreactivity through the IL-4_receptor-alpha_chain and STAT-6 independently of IL-5 and eotaxin .
9570558	0	IL-5	63,67	CC_chemokine_receptors_1_and_3	0,30	IL-5	CC chemokine receptors 1 and 3	3567	1232	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	CC_chemokine_receptors_1_and_3 are differentially regulated by IL-5 during maturation of eosinophilic HL-60 cells .
22310911	0	IL-5	0,4	CD25	48,52	IL-5	CD25	3567	3559	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|induction induction|nmod|cells cells|compound|END_ENTITY	IL-5 promotes induction of antigen-specific CD4 + CD25 + T regulatory cells that suppress autoimmunity .
10584413	0	IL-5	16,20	CD34	64,68	IL-5	CD34	3567	947	Gene	Gene	expression|compound|START_ENTITY Upregulation|nmod|expression marrow-derived|nsubj|Upregulation marrow-derived|dobj|cells cells|nummod|END_ENTITY	Upregulation of IL-5 receptor expression on bone marrow-derived CD34 + cells from patients with asthma .
15355467	0	IL-5	57,61	CD34	32,36	IL-5	CD34	16191(Tax:10090)	12490(Tax:10090)	Gene	Gene	release|xcomp|START_ENTITY stimulates|advcl|release stimulates|dobj|cells cells|compound|END_ENTITY	Allergen stimulates bone marrow CD34 -LRB- + -RRB- cells to release IL-5 in vitro ; a mechanism involved in eosinophilic_inflammation ?
19968630	0	IL-5	0,4	CD34	39,43	IL-5	CD34	3567	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-5 expression and release from human CD34 cells in vitro ; ex vivo evidence from cases of asthma and Churg-Strauss_syndrome .
9831865	0	IL-5	67,71	CD34	143,147	IL-5	CD34	3567	947	Gene	Gene	proteins|nmod|START_ENTITY proteins|nmod|differentiation differentiation|nmod|hematopoietic hematopoietic|compound|END_ENTITY	Differential activation of functionally distinct STAT5 proteins by IL-5 and GM-CSF during eosinophil and neutrophil differentiation from human CD34 + hematopoietic stem cells .
10590258	0	IL-5	95,99	CD4	0,3	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY epitope|dobj|production expressing|ccomp|epitope induced|xcomp|expressing cells|acl|induced T|dobj|cells T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cells induced by virus-like particles expressing a major T cell epitope down-regulate IL-5 production in an ongoing immune response to Der p_1 independently of IFN-gamma production .
10598017	0	IL-5	43,47	CD4	24,27	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|xcomp|START_ENTITY produce|nsubj|cells cells|nummod|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
10598017	0	IL-5	43,47	CD4	66,69	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|xcomp|START_ENTITY produce|advcl|produce produce|nsubj|cells cells|compound|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
11504693	0	IL-5	17,21	CD4	54,57	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY AHR|nmod|transgenic_mice cells|nsubj|AHR cells|amod|dependent dependent|nmod|END_ENTITY	Intrinsic AHR in IL-5 transgenic_mice is dependent on CD4 -LRB- + -RRB- cells and CD49d-mediated signaling .
11544451	0	IL-5	61,65	CD4	84,87	IL-5	CD4	3567	920	Gene	Gene	binding|nmod|START_ENTITY promoter|amod|binding promoter|nmod|cells cells|compound|END_ENTITY	Dexamethasone inhibits the binding of nuclear factors to the IL-5 promoter in human CD4 T cells .
11741821	0	IL-5	22,26	CD4	52,55	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY identifies|nsubj|expression identifies|ccomp|T T|nsubj|END_ENTITY	Ectopic expression of IL-5 identifies an additional CD4 -LRB- + -RRB- T cell mechanism of airway eosinophil recruitment .
11943672	0	IL-5	70,74	CD4	0,3	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY occurs|nmod|expression T|ccomp|occurs T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cell-dependent airway mucus production occurs in response to IL-5 expression in lung .
1350983	0	IL-5	32,36	CD4	60,63	IL-5	CD4	3567	920	Gene	Gene	production|compound|START_ENTITY production|nmod|helper helper|amod|vitro vitro|nmod|+ +|compound|END_ENTITY	Aberrant interleukin -LRB- IL -RRB- -4 and IL-5 production in vitro by CD4 + helper T cells from atopic subjects .
15214040	0	IL-5	99,103	CD4	0,3	IL-5	CD4	3567	920	Gene	Gene	secrete|xcomp|START_ENTITY subset|acl:relcl|secrete IL-2Ralpha|acl:relcl|subset IL-2Ralpha|amod|END_ENTITY	CD4 -LRB- - -RRB- c-kit -LRB- - -RRB- CD3epsilon -LRB- - -RRB- IL-2Ralpha -LRB- + -RRB- Peyer 's patch cells are a novel cell subset which secrete IL-5 in response to IL-2 : implications for their role in IgA production .
15947486	0	IL-5	18,22	CD4	45,48	IL-5	CD4	3567	920	Gene	Gene	gene|compound|START_ENTITY GATA-3|nmod|gene Role|nmod|GATA-3 transcription|nsubj|Role transcription|nmod|cells cells|nummod|END_ENTITY	Role of GATA-3 in IL-5 gene transcription by CD4 + T cells of asthmatic patients .
16364153	0	IL-5	30,34	CD4	0,3	IL-5	CD4	3567	920	Gene	Gene	production|compound|START_ENTITY perpetuate|dobj|production perpetuate|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + CD30 + T cells perpetuate IL-5 production in Dermatophagoides_pteronyssinus allergic patients .
1967279	0	IL-5	80,84	CD4	14,17	IL-5	CD4	3567	920	Gene	Gene	IFN-gamma|compound|START_ENTITY factor|compound|IFN-gamma produce|dobj|factor produce|nsubj|+ +|compound|END_ENTITY	Host-reactive CD4 + and CD8 + T cell clones isolated from a human chimera produce IL-5 , IL-2 , IFN-gamma and granulocyte/macrophage-colony-stimulating _ factor but not IL-4 .
21215348	0	IL-5	0,4	CD4	16,19	IL-5	CD4	3567	920	Gene	Gene	release|compound|START_ENTITY release|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-5 release of CD4 + non-effector lymphocytes is increased in COPD -- modulating effects of moxifloxacin and dexamethasone .
22310911	0	IL-5	0,4	CD4	44,47	IL-5	CD4	3567	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|induction induction|nmod|cells cells|compound|END_ENTITY	IL-5 promotes induction of antigen-specific CD4 + CD25 + T regulatory cells that suppress autoimmunity .
22627364	0	IL-5	82,86	CD4	117,120	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|acl|cells cells|compound|END_ENTITY	Higher sensitivity of male CD4 + T cells to suppressive effects of CD8 + T cells on IL-5 production compared to female CD4 + T cells .
22627364	0	IL-5	82,86	CD4	27,30	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY suppressive|nmod|production +|xcomp|suppressive +|nsubj|sensitivity sensitivity|nmod|END_ENTITY	Higher sensitivity of male CD4 + T cells to suppressive effects of CD8 + T cells on IL-5 production compared to female CD4 + T cells .
26700766	0	IL-5	85,89	CD4	53,56	IL-5	CD4	3567	920	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	LZTFL1 Upregulated by All-trans_Retinoic_Acid during CD4 + T Cell Activation Enhances IL-5 Production .
7540862	0	IL-5	0,4	CD4	19,22	IL-5	CD4	3567	920	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|nummod|END_ENTITY	IL-5 production by CD4 + T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin_A .
8658534	0	IL-5	35,39	CD4	65,68	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	superinduction|compound|START_ENTITY superinduction|nmod|cells cells|compound|END_ENTITY	Vomitoxin-mediated IL-2 , IL-4 , and IL-5 superinduction in murine CD4 + T cells stimulated with phorbol ester calcium ionophore : relation to kinetics of proliferation .
8661368	0	IL-5	35,39	CD4	65,68	IL-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	Superinduction|compound|START_ENTITY Superinduction|nmod|Stimulated Stimulated|compound|END_ENTITY	Vomitoxin-Mediated IL-2 , IL-4 , and IL-5 Superinduction in Murine CD4 + T Cells Stimulated with Phorbol Ester and Calcium Ionophore : Relation to Kinetics of Proliferation The effects of the trichothecene vomitoxin -LRB- VT -RRB- on the kinetics of cell proliferation and cytokine production were evaluated in murine CD4 -LRB- + -RRB- T cells .
9111503	0	IL-5	0,4	CD4	38,41	IL-5	CD4	3567	920	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	IL-5 secretion by allergen-stimulated CD4 + T cells in primary culture : relationship to expression of allergic_disease .
9218830	0	IL-5	0,4	CD4	18,21	IL-5	CD4	3567	920	Gene	Gene	expressed|nsubj|START_ENTITY expressed|nmod|lymphocytes lymphocytes|compound|END_ENTITY	IL-5 expressed by CD4 + lymphocytes from Echinococcus_multilocularis-infected patients .
7917114	0	IL-5	21,25	CD8	43,46	IL-5	CD8	3567	925	Gene	Gene	IL-10|appos|START_ENTITY IL-10|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
17392576	0	IL-5	176,180	CXCL8	188,193	IL-5	CXCL8	3567	3576	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
22901871	0	IL-5	10,14	DREAM	35,40	IL-5	DREAM	3567	30818	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting IL-5 in severe asthma : a DREAM come true ?
15947486	0	IL-5	18,22	GATA-3	8,14	IL-5	GATA-3	3567	2625	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Role of GATA-3 in IL-5 gene transcription by CD4 + T cells of asthmatic patients .
9780145	0	IL-5	35,39	GATA-3	79,85	IL-5	GATA-3	3567	2625	Gene	Gene	genes|compound|START_ENTITY responsiveness|nmod|genes responsiveness|acl|transcription transcription|dobj|END_ENTITY	Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3 .
9209438	0	IL-5	74,78	GATA-4	35,41	IL-5	GATA-4	3567	2626	Gene	Gene	promoter|compound|START_ENTITY regulates|dobj|promoter regulates|nsubj|END_ENTITY	Of the GATA-binding proteins , only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins .
10490850	0	IL-5	67,71	GM-CSF	77,83	IL-5	GM-CSF	3567	1437	Gene	Gene	Association|nmod|START_ENTITY Association|parataxis|IL-3 IL-3|dep|receptor receptor|amod|END_ENTITY	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
10903977	0	IL-5	84,88	GM-CSF	39,45	IL-5	GM-CSF	16191(Tax:10090)	12981(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Murine myeloid progenitor responses to GM-CSF and eosinophil precursor responses to IL-5 represent distinct targets for downmodulation by prostaglandin_E -LRB- 2 -RRB- .
12759409	0	IL-5	150,154	GM-CSF	129,135	IL-5	GM-CSF	3567	1437	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Differential regulation of human eosinophil IL-3 , IL-5 , and GM-CSF receptor alpha-chain expression by cytokines : IL-3 , IL-5 , and GM-CSF down-regulate IL-5 receptor alpha expression with loss of IL-5 responsiveness , but up-regulate IL-3 receptor alpha expression .
18178860	0	IL-5	9,13	GM-CSF	14,20	IL-5	GM-CSF	16191(Tax:10090)	12981(Tax:10090)	Gene	Gene	IL-3|dep|START_ENTITY END_ENTITY|nsubj|IL-3	The IL-3 / IL-5 / GM-CSF common receptor plays a pivotal role in the regulation of Th2 immunity and allergic_airway_inflammation .
1864012	0	IL-5	11,15	GM-CSF	67,73	IL-5	GM-CSF	3567	1437	Gene	Gene	granulocyte/macrophage|amod|START_ENTITY colony-stimulating_factor|amod|granulocyte/macrophage colony-stimulating_factor|appos|END_ENTITY	Effects of IL-5 , granulocyte/macrophage _ colony-stimulating_factor -LRB- GM-CSF -RRB- and IL-3 on the survival of human blood eosinophils in vitro .
9794243	0	IL-5	70,74	GM-CSF	75,81	IL-5	GM-CSF	3567	1437	Gene	Gene	START_ENTITY|dep|family family|amod|END_ENTITY	Regulation of proliferation , differentiation and survival by the IL-3 / IL-5 / GM-CSF receptor family .
10582110	0	IL-5	30,34	IFN-gamma	36,45	IL-5	IFN-gamma	3567	3458	Gene	Gene	IL-8|compound|START_ENTITY IL-8|appos|END_ENTITY	Increased expression of IL-4 , IL-5 , IFN-gamma , IL-6 , IL-8 , and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis .
21744329	0	IL-5	61,65	IFN-gamma	85,94	IL-5	IFN-gamma	3567	3458	Gene	Gene	IL-13|compound|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
10671193	0	IL-5	26,30	IL-10	0,5	IL-5	IL-10	16191(Tax:10090)	16153(Tax:10090)	Gene	Gene	overproduction|compound|START_ENTITY prevents|dobj|overproduction prevents|nsubj|deficiency deficiency|compound|END_ENTITY	IL-10 deficiency prevents IL-5 overproduction and eosinophilic_inflammation in a murine model of asthma-like reaction .
14561490	0	IL-5	67,71	IL-10	0,5	IL-5	IL-10	16191(Tax:10090)	16153(Tax:10090)	Gene	Gene	overlap|nmod|START_ENTITY induces|parataxis|overlap induces|nsubj|END_ENTITY	IL-10 induces gene expression in macrophages : partial overlap with IL-5 but not with IL-4 induced genes .
17392576	0	IL-5	176,180	IL-10	202,207	IL-5	IL-10	3567	3586	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|IL-13 IL-13|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
26282695	0	IL-5	97,101	IL-10	110,115	IL-5	IL-10	3567	3586	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Cytokine profile of food-allergic post-liver transplant children is identified by high levels of IL-5 and low IL-10 secretion from patients ' peripheral blood mononuclear cells .
26282695	0	IL-5	97,101	IL-10	110,115	IL-5	IL-10	3567	3586	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Cytokine profile of food-allergic post-liver transplant children is identified by high levels of IL-5 and low IL-10 secretion from patients ' peripheral blood mononuclear cells .
7512591	0	IL-5	18,22	IL-10	75,80	IL-5	IL-10	3567	3586	Gene	Gene	production|compound|START_ENTITY inhibited|nsubjpass|production inhibited|nmod|END_ENTITY	B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10 .
8683140	0	IL-5	39,43	IL-10	14,19	IL-5	IL-10	16191(Tax:10090)	16153(Tax:10090)	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	Modulation by IL-10 of antigen-induced IL-5 generation , and CD4 + T lymphocyte and eosinophil infiltration into the mouse peritoneal cavity .
11590387	0	IL-5	57,61	IL-13	0,5	IL-5	IL-13	16191(Tax:10090)	16163(Tax:10090)	Gene	Gene	mechanism|amod|START_ENTITY lung|nmod|mechanism induces|nmod|lung induces|nsubj|END_ENTITY	IL-13 induces eosinophil recruitment into the lung by an IL-5 - and eotaxin-dependent mechanism .
14598258	0	IL-5	59,63	IL-13	14,19	IL-5	IL-13	16191(Tax:10090)	16163(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Intratracheal IL-13 induces eosinophilic_esophagitis by an IL-5 , eotaxin-1 , and STAT6-dependent mechanism .
15563687	0	IL-5	72,76	IL-13	0,5	IL-5	IL-13	16191(Tax:10090)	16163(Tax:10090)	Gene	Gene	hyperresponsiveness|nmod|START_ENTITY mediate|dobj|hyperresponsiveness mediate|nsubj|END_ENTITY	IL-13 may mediate allergen-induced hyperresponsiveness independently of IL-5 or eotaxin by effects on airway_smooth_muscle .
16495517	0	IL-5	15,19	IL-13	78,83	IL-5	IL-13	16191(Tax:10090)	16163(Tax:10090)	Gene	Gene	Interleukin-5|appos|START_ENTITY augments|nsubj|Interleukin-5 augments|advcl|regulating regulating|dobj|activity activity|compound|END_ENTITY	Interleukin-5 -LRB- IL-5 -RRB- augments the progression of liver_fibrosis by regulating IL-13 activity .
17392576	0	IL-5	176,180	IL-13	209,214	IL-5	IL-13	3567	3596	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
11240948	0	IL-5	15,19	IL-16	0,5	IL-5	IL-16	3567	3603	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-16 inhibits IL-5 production by antigen-stimulated T cells in atopic subjects .
10329845	0	IL-5	31,35	IL-2	113,117	IL-5	IL-2	3567	3558	Gene	Gene	gene|compound|START_ENTITY control|nmod|gene T|nsubj|control T|parataxis|regulated regulated|nmod|synthesis synthesis|compound|END_ENTITY	Transcriptional control of the IL-5 gene by human helper T cells : IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis .
10329845	0	IL-5	66,70	IL-2	113,117	IL-5	IL-2	3567	3558	Gene	Gene	synthesis|compound|START_ENTITY regulated|nsubjpass|synthesis regulated|nmod|synthesis synthesis|compound|END_ENTITY	Transcriptional control of the IL-5 gene by human helper T cells : IL-5 synthesis is regulated independently from IL-2 or IL-4 synthesis .
10525317	0	IL-5	72,76	IL-2	37,41	IL-5	IL-2	3567	3558	Gene	Gene	IL-4|dep|START_ENTITY cytokines|appos|IL-4 _|dobj|cytokines _|nsubj|detection detection|appos|END_ENTITY	Flow cytometric detection of type 1 -LRB- IL-2 , IFN-gamma -RRB- _ and_type_2 -LRB- IL-4 , IL-5 -RRB- cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid_arthritis , allergic_asthma and atopic_dermatitis .
12884295	0	IL-5	15,19	IL-2	102,106	IL-5	IL-2	3567	3558	Gene	Gene	production|compound|START_ENTITY Sensitivity|nmod|production reduced|nsubjpass|Sensitivity reduced|nmod|END_ENTITY	Sensitivity of IL-5 production to the cAMP-dependent pathway in human T cells is reduced by exogenous IL-2 in a phosphoinositide 3-kinase-dependent way .
15214040	0	IL-5	99,103	IL-2	119,123	IL-5	IL-2	3567	3558	Gene	Gene	secrete|xcomp|START_ENTITY secrete|nmod|END_ENTITY	CD4 -LRB- - -RRB- c-kit -LRB- - -RRB- CD3epsilon -LRB- - -RRB- IL-2Ralpha -LRB- + -RRB- Peyer 's patch cells are a novel cell subset which secrete IL-5 in response to IL-2 : implications for their role in IgA production .
17392576	0	IL-5	176,180	IL-2	164,168	IL-5	IL-2	3567	3558	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
1884020	0	IL-5	85,89	IL-2	33,37	IL-5	IL-2	3567	3558	Gene	Gene	concentrations|nmod|START_ENTITY results|nmod|concentrations results|nsubj|Administration Administration|appos|END_ENTITY	Administration of interleukin-2 -LRB- IL-2 -RRB- results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer .
2373861	1	IL-5	78,82	IL-2	91,95	IL-5	IL-2	16191(Tax:10090)	16183(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	In vivo and in vitro expression of IL-5 mRNA by IL-2 .
8330315	0	IL-5	18,22	IL-2	100,104	IL-5	IL-2	3567	3558	Gene	Gene	augments|nsubj|START_ENTITY augments|nmod|lymphocytes lymphocytes|nmod|presence presence|nmod|END_ENTITY	Recombinant human IL-5 augments immunoglobulin generation by human B lymphocytes in the presence of IL-2 .
8419486	0	IL-5	24,28	IL-2	0,4	IL-5	IL-2	16191(Tax:10090)	16183(Tax:10090)	Gene	Gene	response|compound|START_ENTITY contributes|nmod|response contributes|nsubj|END_ENTITY	IL-2 contributes to the IL-5 response in granulomas from mice infected with Schistosoma_mansoni .
8982773	0	IL-5	69,73	IL-2	19,23	IL-5	IL-2	3567	3558	Gene	Gene	transcription|nmod|START_ENTITY role|nmod|transcription role|nmod|END_ENTITY	A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones .
9237106	0	IL-5	13,17	IL-2	32,36	IL-5	IL-2	3567	3558	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of IL-5 expression by IL-2 is resistant to the immunosuppressive agents cyclosporin_A and rapamycin .
9794243	0	IL-5	70,74	IL-3	65,69	IL-5	IL-3	3567	3562	Gene	Gene	Regulation|parataxis|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of proliferation , differentiation and survival by the IL-3 / IL-5 / GM-CSF receptor family .
18802081	0	IL-5	31,35	IL-33	0,5	IL-5	IL-33	16191(Tax:10090)	77125(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	IL-33 induces antigen-specific IL-5 + T cells and promotes allergic-induced airway inflammation independent of IL-4 .
10880839	0	IL-5	73,77	IL-4	68,72	IL-5	IL-4	3567	3565	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Multiple HLA-class I-specific inhibitory NK receptor expression and IL-4 / IL-5 production by CD8 + T-cell clones in HIV-1_infection .
10922233	0	IL-5	36,40	IL-4	53,57	IL-5	IL-4	3567	3565	Gene	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	Allergen-induced mRNA expression of IL-5 , but not of IL-4 and IFN-gamma , in peripheral blood mononuclear cells is a key feature of clinical manifestation of seasonal_allergic_rhinitis .
12150887	0	IL-5	74,78	IL-4	0,4	IL-5	IL-4	16191(Tax:10090)	16189(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY induces|nmod|absence induces|nsubj|END_ENTITY	IL-4 induces characteristic Th2 responses even in the combined absence of IL-5 , IL-9 , and IL-13 .
1347306	1	IL-5	173,177	IL-4	219,223	IL-5	IL-4	3567	3565	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement by IL-5 , specific inhibition of IgA synthesis by IL-4 .
14634065	0	IL-5	140,144	IL-4	148,152	IL-5	IL-4	3567	3565	Gene	Gene	START_ENTITY|nmod|priming priming|compound|END_ENTITY	Comparative cytokine profile of human skin mast cells from two compartments -- strong resemblance with monocytes at baseline but induction of IL-5 by IL-4 priming .
1552290	0	IL-5	15,19	IL-4	71,75	IL-5	IL-4	16191(Tax:10090)	16189(Tax:10090)	Gene	Gene	Interleukin_5|appos|START_ENTITY provides|nsubj|Interleukin_5 provides|dobj|signal signal|acl:relcl|required required|nmod|END_ENTITY	Interleukin_5 -LRB- IL-5 -RRB- provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin -LRB- Ig -RRB- G1 and IgE .
16929824	0	IL-5	43,47	IL-4	37,41	IL-5	IL-4	3567	3565	Gene	Gene	tissues|compound|START_ENTITY -RSB-|nsubj|tissues -RSB-|advcl|-LSB- -LSB-|dobj|concentration concentration|nmod|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17392576	0	IL-5	176,180	IL-4	170,174	IL-5	IL-4	3567	3565	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
1830499	0	IL-5	93,97	IL-4	86,90	IL-5	IL-4	16191(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|appos|END_ENTITY	Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 -LRB- IL-4 -RRB- , IL-5 , and gamma-interferon , but not IL-2 by activated murine T cells .
2295790	0	IL-5	0,4	IL-4	22,26	IL-5	IL-4	3567	3565	Gene	Gene	up-regulates|compound|START_ENTITY up-regulates|nmod|END_ENTITY	IL-5 up-regulates but IL-4 down-regulates IL-2R expression on a cloned B_lymphoma line .
25330644	0	IL-5	62,66	IL-4	56,60	IL-5	IL-4	24497(Tax:10116)	287287(Tax:10116)	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|nmod|expression expression|nmod|END_ENTITY	-LSB- Prophylactic effect of budesonide on the expression of IL-4 , IL-5 in model of allergic_rhinitis rats -RSB- .
26224246	0	IL-5	157,161	IL-4	151,155	IL-5	IL-4	16191(Tax:10090)	16189(Tax:10090)	Gene	Gene	balance|compound|START_ENTITY END_ENTITY|appos|balance	Treg depletion attenuates irradiation-induced pulmonary_fibrosis by reducing fibrocyte accumulation , inducing Th17 response , and shifting IFN-y , IL-12 / IL-4 , IL-5 balance .
7730620	0	IL-5	14,18	IL-4	73,77	IL-5	IL-4	3567	3565	Gene	Gene	Production|nmod|START_ENTITY secretion|nsubj|Production secretion|nmod|END_ENTITY	Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4 , IL-10 , and IL-12 .
7917114	0	IL-5	21,25	IL-4	15,19	IL-5	IL-4	3567	3565	Gene	Gene	IL-10|appos|START_ENTITY IL-10|appos|END_ENTITY	Non-cytotoxic , IL-4 , IL-5 , IL-10 producing CD8 + T cells : their activation and effector functions .
8920874	0	IL-5	72,76	IL-4	38,42	IL-5	IL-4	16191(Tax:10090)	16189(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|production production|compound|END_ENTITY	Schistosoma_mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils .
9037001	7	IL-5	1458,1462	IL-4	1363,1367	IL-4	IL-3	16189(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY effects|nmod|expression reaction|nmod|effects regulates|nmod|reaction regulates|nsubj|END_ENTITY	The cytokine mRNA profile correlating with the lack of eosinophil recruitment was variable ; the data suggest that IL-4 regulates eosinophil involvement in the xeno-rejection reaction indirectly via effects on IL-5 and IL-3 transcript expression .
9470918	0	IL-5	28,32	IL-4	22,26	IL-5	IL-4	3567	3565	Gene	Gene	mRNAs|nsubj|START_ENTITY mRNAs|nmod|expression expression|nmod|END_ENTITY	In vivo expression of IL-4 , IL-5 , IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin_A in a patient with Kimura 's _ disease .
11694459	0	IL-5	114,118	IL-4_receptor-alpha_chain	60,85	IL-5	IL-4 receptor-alpha chain	16191(Tax:10090)	16190(Tax:10090)	Gene	Gene	independently|nmod|START_ENTITY independently|amod|END_ENTITY	Interleukin-13 mediates airways_hyperreactivity through the IL-4_receptor-alpha_chain and STAT-6 independently of IL-5 and eotaxin .
9209438	0	IL-5	74,78	IL-5	96,100	IL-5	IL-5	3567	3567	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|cells cells|compound|END_ENTITY	Of the GATA-binding proteins , only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins .
9209438	0	IL-5	96,100	IL-5	74,78	IL-5	IL-5	3567	3567	Gene	Gene	cells|compound|START_ENTITY promoter|nmod|cells promoter|compound|END_ENTITY	Of the GATA-binding proteins , only GATA-4 selectively regulates the human IL-5 gene promoter in IL-5 producing cells which express multiple GATA-binding proteins .
10489836	0	IL-5	58,62	IL-6	98,102	IL-5	IL-6	3567	3569	Gene	Gene	responses|compound|START_ENTITY macrophages|nmod|responses effects|nmod|macrophages correlate|nsubj|effects correlate|nmod|END_ENTITY	Modulatory effects of alveolar macrophages on CD4 + T-cell IL-5 responses correlate with IL-1beta , IL-6 , and IL-12 production .
10582110	0	IL-5	30,34	IL-6	47,51	IL-5	IL-6	3567	3569	Gene	Gene	IL-8|compound|START_ENTITY IL-8|appos|END_ENTITY	Increased expression of IL-4 , IL-5 , IFN-gamma , IL-6 , IL-8 , and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis .
16929824	0	IL-5	43,47	IL-6	49,53	IL-5	IL-6	3567	3569	Gene	Gene	tissues|compound|START_ENTITY tissues|dep|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17392576	0	IL-5	176,180	IL-6	182,186	IL-5	IL-6	3567	3569	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
19478959	0	IL-5	73,77	IL-6	79,83	IL-5	IL-6	3567	3569	Gene	Gene	IL-12|compound|START_ENTITY IL-12|appos|END_ENTITY	Does Toxoplasma_gondii_infection affect the levels of IgE and cytokines -LRB- IL-5 , IL-6 , IL-10 , IL-12 , and TNF-alpha -RRB- ?
21744329	0	IL-5	61,65	IL-6	67,71	IL-5	IL-6	3567	3569	Gene	Gene	IL-13|compound|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
9741339	0	IL-5	50,54	IgA	11,14	IL-5	IgA	16191(Tax:10090)	12518(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|cells cells|compound|END_ENTITY	Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent .
2518658	0	IL-5	105,109	Interferon-gamma	0,16	IL-5	Interferon-gamma	16191(Tax:10090)	15978(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits the proliferation but not the differentiation of murine B cells in response to IL-5 .
2246506	0	IL-5	0,4	Pgp-1	15,20	IL-5	Pgp-1	3567	960	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	IL-5 induces a Pgp-1 -LRB- CD44 -RRB- bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate .
10490850	0	IL-5	67,71	RACK1	15,20	IL-5	RACK1	3567	10399	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
16696320	0	IL-5	0,4	TGF-beta1	36,45	IL-5	TGF-beta1	3567	7040	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	IL-5 up-regulates the expression of TGF-beta1 in human blood eosinophils in vitro .
21744329	0	IL-5	61,65	TNF	80,83	IL-5	TNF	3567	7124	Gene	Gene	IL-13|compound|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
16373364	0	IL-5	71,75	Th2	99,102	IL-5	Th2	16191(Tax:10090)	15111(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	A role for Ets1 , synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes .
9574547	0	IL-5	24,28	alpha-chain	38,49	IL-5	alpha-chain	3567	2217	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5 , IL-3 , _ and_granulocyte-macrophage_colony-stimulating_factor in human blood eosinophils .
9574547	0	IL-5	72,76	alpha-chain	38,49	IL-5	alpha-chain	3567	2217	Gene	Gene	and_granulocyte-macrophage_colony-stimulating_factor|compound|START_ENTITY transcription|nmod|and_granulocyte-macrophage_colony-stimulating_factor transcription|nsubj|inhibition inhibition|nmod|gene gene|amod|END_ENTITY	Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5 , IL-3 , _ and_granulocyte-macrophage_colony-stimulating_factor in human blood eosinophils .
1830499	0	IL-5	93,97	interleukin-4	71,84	IL-5	interleukin-4	16191(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 -LRB- IL-4 -RRB- , IL-5 , and gamma-interferon , but not IL-2 by activated murine T cells .
7935454	0	IL-5	52,56	interleukin-5	37,50	IL-5	interleukin-5	16191(Tax:10090)	16191(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	A critical cytoplasmic domain of the interleukin-5 -LRB- IL-5 -RRB- receptor alpha chain and its function in IL-5-mediated growth signal transduction .
8110039	0	IL-5	43,47	interleukin-5	28,41	IL-5	interleukin-5	3567	3567	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	-LSB- Protein phosphorylation in interleukin-5 -LRB- IL-5 -RRB- - stimulated human peripheral blood eosinophils -RSB- .
14630618	0	IL-5Ralpha	12,22	CD34	7,11	IL-5Ralpha	CD34	3568	947	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Sputum CD34 + IL-5Ralpha + cells increase after allergen : evidence for in situ eosinophilopoiesis .
15528381	0	IL-5_and_granulocyte-macrophage_colony-stimulating_factor	0,57	STAT3	67,72	IL-5 and granulocyte-macrophage colony-stimulating factor	STAT3	3567;1437	6774	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	IL-5_and_granulocyte-macrophage_colony-stimulating_factor activate STAT3 and STAT5 and promote Pim-1 and cyclin_D3 protein expression in human eosinophils .
25130545	0	IL-6	96,100	ADAM10	38,44	IL-6	ADAM10	3569	102	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	The disintegrin and metalloproteinase ADAM10 mediates a canonical Notch-dependent regulation of IL-6 through Dll4 in human endothelial cells .
26561568	0	IL-6	16,20	ADAM17	0,6	IL-6	ADAM17	16193(Tax:10090)	11491(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Ra from the cell surface of leukocytes during inflammatory responses .
24504026	0	IL-6	0,4	APRIL	89,94	IL-6	APRIL	3569	8741	Gene	Gene	supports|nsubj|START_ENTITY supports|nmod|END_ENTITY	IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors .
23862741	0	IL-6	49,53	Act1	12,16	IL-6	Act1	3569	10758	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	The role of Act1 , a NF-kB-activating protein , in IL-6 and IL-8 levels induced by IL-17 stimulation in SW982 cells .
17911635	0	IL-6	21,25	Adiponectin	0,11	IL-6	Adiponectin	3569	9370	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor , AMPK , p38 , and NF-kappa_B pathway .
19817504	0	IL-6	48,52	AgRP	32,36	IL-6	AgRP	24498(Tax:10116)	25582(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
24650887	0	IL-6	138,142	Akt	214,217	IL-6	Akt	16193(Tax:10090)	11651(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|p-c-JUN_and_JNK p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
17109863	0	IL-6	23,27	Angiotensin_II	0,14	IL-6	Angiotensin II	16193(Tax:10090)	11847(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces IL-6 expression and the Jak-STAT3 pathway in aortic adventitia of LDL_receptor-deficient mice .
17114490	0	IL-6	31,35	Annexin_1	0,9	IL-6	Annexin 1	16193(Tax:10090)	16952(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Annexin_1 negatively regulates IL-6 expression via effects on p38_MAPK and MAPK_phosphatase-1 .
24227780	0	IL-6	27,31	BANK1	0,5	IL-6	BANK1	16193(Tax:10090)	242248(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY controls|dobj|secretion controls|nsubj|END_ENTITY	BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway .
16732314	0	IL-6	19,23	BCL3	0,4	IL-6	BCL3	3569	602	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription .
2503436	1	IL-6	169,173	BSF-2	163,168	IL-6	BSF-2	3569	3569	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of BSF-2 / IL-6 and IL-1 .
23108993	0	IL-6	137,141	Bax	80,83	IL-6	Bax	100008733(Tax:9986)	100355675(Tax:9986)	Gene	Gene	mRNA|appos|START_ENTITY expression|dep|mRNA expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
10067009	0	IL-6	15,19	Bcl-2	55,60	IL-6	Bcl-2	3569	596	Gene	Gene	Interleukin-6|appos|START_ENTITY change|nsubj|Interleukin-6 change|dobj|expression expression|nmod|protein protein|compound|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- does not change the expression of Bcl-2 protein in the prevention of cisplatin-induced apoptosis in ovarian_cancer cell lines .
11641360	0	IL-6	110,114	Bcl-2	0,5	IL-6	Bcl-2	16193(Tax:10090)	12043(Tax:10090)	Gene	Gene	sickness|nmod|START_ENTITY signs|nmod|sickness mice|nmod|signs recovery|nmod|mice mediates|nmod|recovery mediates|nsubj|END_ENTITY	Bcl-2 mediates sex-specific differences in recovery of mice from LPS-induced signs of sickness independent of IL-6 .
23108993	0	IL-6	137,141	Bcl-2	85,90	IL-6	Bcl-2	100008733(Tax:9986)	100009447(Tax:9986)	Gene	Gene	mRNA|appos|START_ENTITY expression|dep|mRNA expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
15625014	0	IL-6	47,51	Bcl-x	38,43	IL-6	Bcl-x	3569	598	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of alternative splicing of Bcl-x by IL-6 , GM-CSF and TPA .
18025155	0	IL-6	43,47	Bmx	0,3	IL-6	Bmx	3569	660	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|kinase kinase|compound|END_ENTITY	Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp -RCB- B activity .
18402776	0	IL-6	26,30	Bmx	0,3	IL-6	Bmx	3569	660	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts .
11028659	0	IL-6	22,26	Bradykinin	0,10	IL-6	Bradykinin	3569	3827	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK - and p38_MAPK-dependent mechanisms .
25109623	0	IL-6	22,26	Bradykinin	0,10	IL-6	Bradykinin	3569	3827	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Bradykinin stimulates IL-6 production and cell invasion in colorectal_cancer cells .
20978825	0	IL-6	101,105	C-reactive_protein	20,38	IL-6	C-reactive protein	3569	1401	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Adiponectin reduces C-reactive_protein expression and downregulates STAT3 phosphorylation induced by IL-6 in HepG2 cells .
22108347	0	IL-6	24,28	C-reactive_protein	37,55	IL-6	C-reactive protein	3569	1401	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Ursolic_acid suppresses IL-6 induced C-reactive_protein expression in HepG2 and protects HUVECs from injury induced by CRP .
10799912	0	IL-6	101,105	C5a	38,41	IL-6	C5a	24498(Tax:10116)	362119(Tax:10116)	Gene	Gene	rats|nmod|START_ENTITY treatment|nmod|rats receptors|nmod|treatment receptors|nsubj|Induction Induction|nmod|END_ENTITY	Induction of functional anaphylatoxin C5a receptors on hepatocytes by in vivo treatment of rats with IL-6 .
11564816	0	IL-6	161,165	C5a	14,17	IL-6	C5a	24498(Tax:10116)	362119(Tax:10116)	Gene	Gene	release|compound|START_ENTITY hepatocytes|nmod|release expression|nmod|hepatocytes actions|dep|expression actions|amod|END_ENTITY	Anaphylatoxin C5a actions in rat liver : synergistic enhancement by C5a of lipopolysaccharide-dependent alpha -LRB- 2 -RRB- - macroglobulin gene expression in hepatocytes via IL-6 release from Kupffer cells .
11564816	0	IL-6	161,165	C5a	67,70	IL-6	C5a	24498(Tax:10116)	362119(Tax:10116)	Gene	Gene	release|compound|START_ENTITY hepatocytes|nmod|release expression|nmod|hepatocytes actions|dep|expression actions|dep|enhancement enhancement|nmod|END_ENTITY	Anaphylatoxin C5a actions in rat liver : synergistic enhancement by C5a of lipopolysaccharide-dependent alpha -LRB- 2 -RRB- - macroglobulin gene expression in hepatocytes via IL-6 release from Kupffer cells .
12496437	0	IL-6	22,26	C5a	68,71	IL-6	C5a	16193(Tax:10090)	15139(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY effects|nmod|blockade linked|nsubjpass|effects linked|nmod|expression expression|amod|END_ENTITY	Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression .
14688199	0	IL-6	38,42	C5a	19,22	IL-6	C5a	24498(Tax:10116)	362119(Tax:10116)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Regulatory role of C5a in LPS-induced IL-6 production by neutrophils during sepsis .
1602137	0	IL-6	107,111	C5a	72,75	IL-6	C5a	3569	728	Gene	Gene	synthesis|compound|START_ENTITY stimulation|nmod|synthesis responsible|nmod|stimulation Identification|amod|responsible Identification|nmod|region region|nmod|END_ENTITY	Identification and characterization of the effector region within human C5a responsible for stimulation of IL-6 synthesis .
23343403	0	IL-6	13,17	CCN4	0,4	IL-6	CCN4	3569	8840	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	CCN4 induces IL-6 production through avb5 receptor , PI3K , Akt , and NF-kB singling pathway in human synovial fibroblasts .
17379849	0	IL-6	70,74	CC_chemokine_ligand_2	4,25	IL-6	CC chemokine ligand 2	3569	6347	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The CC_chemokine_ligand_2 -LRB- CCL2 -RRB- mediates fibroblast survival through IL-6 .
22084439	0	IL-6	13,17	CD161	86,91	IL-6	CD161	3569	3820	Gene	Gene	reduces|nsubj|START_ENTITY reduces|advcl|allowing allowing|dobj|emergence emergence|nmod|cells cells|compound|END_ENTITY	Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161 + CD4 + regulatory T cells .
15935883	0	IL-6	0,4	CD25	106,110	IL-6	CD25	3569	3559	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|effect effect|nmod|cells cells|compound|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
17182564	0	IL-6	0,4	CD25	68,72	IL-6	CD25	16193(Tax:10090)	16184(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|functions functions|nsubj|cell cell|compound|END_ENTITY	IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4 + CD25 + T cell regulatory functions .
17591359	0	IL-6	40,44	CD34	59,63	IL-6	CD34	3569	947	Gene	Gene	production|compound|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Head_and_neck_cancer triggers increased IL-6 production of CD34 + stem cells from human cord blood .
15100309	0	IL-6	0,4	CD4	71,74	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|nmod|manners manners|compound|END_ENTITY	IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4 + T cell - and STAT3-dependent manners .
15728480	0	IL-6	0,4	CD4	78,81	IL-6	CD4	3569	920	Gene	Gene	plays|nsubj|START_ENTITY plays|advcl|initiating initiating|nmod|stage stage|nmod|activation activation|compound|END_ENTITY	IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation .
15935883	0	IL-6	0,4	CD4	101,104	IL-6	CD4	3569	920	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|effect effect|nmod|cells cells|compound|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
17182564	0	IL-6	0,4	CD4	64,67	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|functions functions|nsubj|cell cell|compound|END_ENTITY	IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4 + CD25 + T cell regulatory functions .
17981790	0	IL-6	12,16	CD4	44,47	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	Blocking|nmod|START_ENTITY prevents|nsubj|Blocking prevents|dobj|colitis colitis|compound|END_ENTITY	Blocking of IL-6 signaling pathway prevents CD4 + T cell-mediated colitis in a T -LRB- h -RRB- 17-independent manner .
18490709	0	IL-6	114,118	CD4	20,23	IL-6	CD4	3569	920	Gene	Gene	resistant|nmod|START_ENTITY +|ccomp|resistant +|nsubj|CD25 CD25|compound|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18845487	0	IL-6	15,19	CD4	23,26	IL-6	CD4	3569	920	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|responses responses|compound|END_ENTITY	The effects of IL-6 on CD4 T cell responses .
19050105	0	IL-6	50,54	CD4	99,102	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	signal|compound|START_ENTITY regulated|nmod|signal cells|acl|regulated expression|nmod|cells involved|nsubjpass|expression involved|nmod|death death|compound|END_ENTITY	IFN-gamma expression in CD8 + T cells regulated by IL-6 signal is involved in superantigen-mediated CD4 + T cell death .
19139170	0	IL-6	40,44	CD4	89,92	IL-6	CD4	3569	920	Gene	Gene	production|nmod|START_ENTITY induction|nmod|production mediated|nsubjpass|induction mediated|nmod|IL-21 IL-21|acl|produced produced|nmod|cells cells|compound|END_ENTITY	The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4 + T cells .
19181387	0	IL-6	9,13	CD4	28,31	IL-6	CD4	3569	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Elevated IL-6 expression in CD4 T cells via PKCtheta and NF-kappaB induces Th2 cytokine production .
20083667	0	IL-6	79,83	CD4	8,11	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	trans|compound|START_ENTITY role|nmod|trans underlines|dobj|role underlines|nsubj|Loss Loss|nmod|expression expression|compound|END_ENTITY	Loss of CD4 + T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells .
20519164	0	IL-6	118,122	CD4	45,48	IL-6	CD4	3569	920	Gene	Gene	characterized|nmod|START_ENTITY Th-subpopulation|acl|characterized reveals|dobj|Th-subpopulation reveals|nsubj|profiling profiling|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Cytokine profiling of human peripheral blood CD4 + T lymphocytes reveals a new Th-subpopulation -LRB- Th6 -RRB- characterized by IL-6 .
21048114	0	IL-6	142,146	CD4	21,24	IL-6	CD4	3569	920	Gene	Gene	_|nmod|START_ENTITY _|dep|cells cells|dep|Enrichment Enrichment|nmod|END_ENTITY	Enrichment of Foxp3 + CD4 regulatory T cells in migrated_T cells to IL-6 - _ and_IL-8-expressing tumors through predominant induction of CXCR1 by IL-6 .
21944889	0	IL-6	52,56	CD4	7,10	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|xcomp|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	Na ve CD4 + T cells of Peyer 's patches produce more IL-6 than those of spleen in response to antigenic stimulation .
22025555	0	IL-6	0,4	CD4	50,53	IL-6	CD4	3569	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|rejection rejection|acl|mediated mediated|nmod|cells cells|compound|END_ENTITY	IL-6 promotes cardiac graft rejection mediated by CD4 + cells .
22084439	0	IL-6	13,17	CD4	93,96	IL-6	CD4	3569	920	Gene	Gene	reduces|nsubj|START_ENTITY reduces|advcl|allowing allowing|dobj|emergence emergence|nmod|cells cells|compound|END_ENTITY	Neutralizing IL-6 reduces human arterial allograft rejection by allowing emergence of CD161 + CD4 + regulatory T cells .
22424785	0	IL-6	99,103	CD4	0,3	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	deletion|nmod|START_ENTITY function|nmod|deletion function|nsubj|cells cells|compound|END_ENTITY	CD4 + Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene .
22491065	0	IL-6	0,4	CD4	40,43	IL-6	CD4	3569	920	Gene	Gene	triggers|nsubj|START_ENTITY triggers|nmod|cells cells|compound|END_ENTITY	IL-6 triggers IL-21 production by human CD4 + T cells to drive STAT3-dependent plasma cell differentiation in B cells .
24379058	0	IL-6	12,16	CD4	113,116	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	signal|compound|START_ENTITY Blockade|nmod|signal exacerbates|nsubj|Blockade exacerbates|dobj|acute_inflammatory_bowel_disease acute_inflammatory_bowel_disease|nmod|IL-17 IL-17|acl|producing producing|nmod|population population|compound|END_ENTITY	Blockade of IL-6 signal exacerbates acute_inflammatory_bowel_disease via inhibiting IL-17 producing in activated CD4 + Th17 population .
24681564	0	IL-6	123,127	CD4	61,64	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY signaling|nmod|receptor antagonizing|advcl|signaling limits|advcl|antagonizing limits|dobj|cells cells|compound|differentiation differentiation|nmod|T T|compound|END_ENTITY	The adaptor TRAF5 limits the differentiation of inflammatory CD4 -LRB- + -RRB- T cells by antagonizing signaling via the receptor for IL-6 .
24690994	0	IL-6	10,14	CD4	69,72	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|counteracting counteracting|dobj|Foxp3 Foxp3|nummod|+25 +25|compound|END_ENTITY	Transgene IL-6 enhances DC-stimulated CTL responses by counteracting CD4 +25 + Foxp3 + regulatory T cell suppression via IL-6-induced Foxp3 downregulation .
25100658	0	IL-6	126,130	CD4	6,9	IL-6	CD4	3569	920	Gene	Gene	requiring|dobj|START_ENTITY trigger|xcomp|requiring trigger|nsubj|cells cells|compound|END_ENTITY	Donor CD4 T cells trigger costimulation blockade-resistant donor bone marrow rejection through bystander activation requiring IL-6 .
25797206	0	IL-6	52,56	CD4	19,22	IL-6	CD4	3569	920	Gene	Gene	production|compound|START_ENTITY increased|dobj|production T|ccomp|increased T|nsubj|END_ENTITY	Preterm cord blood CD4 -LRB- + -RRB- T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4 -LRB- + -RRB- T cells in bronchopulmonary_dysplasia .
26759006	0	IL-6	0,4	CD4	131,134	IL-6	CD4	3569	920	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|xcomp|impair impair|dobj|cells cells|compound|activation activation|nmod|T T|compound|END_ENTITY	IL-6 down-regulates HLA class II expression and IL-12 production of human dendritic cells to impair activation of antigen-specific CD4 -LRB- + -RRB- T cells .
7907103	0	IL-6	8,12	CD4	61,64	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|acl|signaling signaling|nmod|responses responses|nmod|END_ENTITY	Role of IL-6 , IL-1 , and CD28 signaling in responses of mouse CD4 + T cells to immobilized anti-TCR monoclonal antibody .
8613355	0	IL-6	148,152	CD4	123,126	IL-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	producing|xcomp|START_ENTITY cells|acl|producing cells|nummod|+ +|compound|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
9472657	0	IL-6	12,16	CD4	126,129	IL-6	CD4	3569	920	Gene	Gene	START_ENTITY|parataxis|associated associated|nmod|cells cells|nummod|END_ENTITY	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9472657	0	IL-6	12,16	CD4	40,43	IL-6	CD4	3569	920	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|dysregulation dysregulation|nmod|cells cells|nummod|END_ENTITY	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
9485207	0	IL-6	61,65	CD4	44,47	IL-6	CD4	3569	920	Gene	Gene	effector|nmod|START_ENTITY effector|dobj|responses responses|nummod|END_ENTITY	Augmentation of naive , Th1 and Th2 effector CD4 responses by IL-6 , IL-1_and_TNF .
25787755	0	IL-6	84,88	CD40L	103,108	IL-6	CD40L	3569	959	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Anthocyanins and their physiologically relevant metabolites alter the expression of IL-6 and VCAM-1 in CD40L and oxidized LDL challenged vascular endothelial cells .
15014527	0	IL-6	0,4	CD44	15,19	IL-6	CD44	3569	960	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-6 regulates CD44 cell surface expression on human myeloma cells .
18451609	0	IL-6	27,31	CD44	0,4	IL-6	CD44	16193(Tax:10090)	12505(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY expression|nmod|mice expression|nsubj|END_ENTITY	CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation .
25126764	0	IL-6	69,73	CD44	41,45	IL-6	CD44	3569	960	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Low molecular weight hyaluronan mediated CD44 dependent induction of IL-6 and chemokines in human dermal fibroblasts potentiates innate immune response .
19380809	0	IL-6	0,4	CD5	15,18	IL-6	CD5	3569	921	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation .
9184920	0	IL-6	66,70	CD5	79,82	IL-6	CD5	16193(Tax:10090)	12507(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	IL-12 directly stimulates expression of IL-10 by CD5 + B cells and IL-6 by both CD5 + and CD5 - B cells : possible involvement in age-associated cytokine dysregulation .
1382861	0	IL-6	0,4	CD56	58,62	IL-6	CD56	3569	4684	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|cells cells|compound|END_ENTITY	IL-6 enhances the cytotoxic activity of thymocyte-derived CD56 + cells .
11303750	0	IL-6	0,4	CNTF	18,22	IL-6	CNTF	24498(Tax:10116)	25707(Tax:10116)	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	IL-6 up-regulates CNTF mRNA expression and enhances neurite regeneration .
12608645	0	IL-6	90,94	COX-2	23,28	IL-6	COX-2	3569	4513	Gene	Gene	synthesis|compound|START_ENTITY COX-2-dependent|nsubj|synthesis evidence|dep|COX-2-dependent expression|dep|evidence expression|compound|END_ENTITY	CD40 ligation triggers COX-2 expression in endothelial cells : evidence that CD40-mediated IL-6 synthesis is COX-2-dependent .
19892012	0	IL-6	26,30	COX-2	13,18	IL-6	COX-2	3569	5743	Gene	Gene	crucial|nsubj|START_ENTITY Induction|parataxis|crucial Induction|nmod|PGE PGE|compound|END_ENTITY	Induction of COX-2 / PGE -LRB- 2 -RRB- / IL-6 is crucial for cigarette_smoke_extract-induced airway_inflammation : Role of TLR4-dependent NADPH oxidase activation .
23886206	0	IL-6	110,114	COX-2	96,101	IL-6	COX-2	16193(Tax:10090)	17709(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
25201048	0	IL-6	60,64	COX-2	33,38	IL-6	COX-2	3569	5743	Gene	Gene	secretion|compound|START_ENTITY expression|dep|secretion expression|compound|END_ENTITY	Sphingosine-1-phosphate mediates COX-2 expression and PGE2 / IL-6 secretion via c-Src-dependent AP-1 activation .
20160059	0	IL-6	59,63	CREB	119,123	IL-6	CREB	3569	1385	Gene	Gene	STAT3|compound|START_ENTITY activating|dobj|STAT3 activating|nmod|END_ENTITY	ZIP4 regulates pancreatic_cancer cell growth by activating IL-6 / STAT3 pathway through zinc finger transcription factor CREB .
23825534	0	IL-6	0,4	CREB	58,62	IL-6	CREB	24498(Tax:10116)	81646(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt / CREB signaling pathway in hepatocytes : implication of an anti-apoptotic role during liver_regeneration .
15668089	0	IL-6	0,4	CRP	71,74	IL-6	CRP	3569	1401	Gene	Gene	levels|compound|START_ENTITY levels|dep|relation relation|acl|END_ENTITY	IL-6 levels in acute and post myocardial_infarction : their relation to CRP levels , infarction size , left ventricular systolic function , and heart_failure .
17141340	0	IL-6	5,9	CRP	0,3	IL-6	CRP	3569	1401	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	CRP , IL-6 and endothelin-1 levels in patients undergoing coronary artery bypass grafting .
2001421	0	IL-6	63,67	CRP	112,115	IL-6	CRP	3569	1401	Gene	Gene	interleukin|amod|START_ENTITY interleukin|acl|stimulated stimulated|dobj|synthesis synthesis|nmod|C-reactive_protein C-reactive_protein|appos|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- inhibits interleukin -LRB- IL -RRB- -1 and/or IL-6 stimulated synthesis of C-reactive_protein -LRB- CRP -RRB- and serum_amyloid_A -LRB- SAA -RRB- in primary cultures of human hepatocytes .
20568512	0	IL-6	20,24	CRP	26,29	IL-6	CRP	3569	1401	Gene	Gene	measurement|appos|START_ENTITY measurement|appos|END_ENTITY	-LSB- Usefulness of PCT , IL-6 , CRP measurement in the prediction of intraamniotic_infection and newborn status in pregnant women with premature_rupture of membranes -RSB- .
20626020	0	IL-6	46,50	CRP	76,79	IL-6	CRP	3569	1401	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Diagnostic usefulness of serum interleukin_6 -LRB- IL-6 -RRB- and C-reactive_protein -LRB- CRP -RRB- in the differentiation between pancreatic_cancer and chronic_pancreatitis .
21031427	0	IL-6	112,116	CRP	15,18	IL-6	CRP	3569	1401	Gene	Gene	reflect|nmod|START_ENTITY reflect|nsubj|levels levels|compound|END_ENTITY	Elevated serum CRP levels after induction chemoradiotherapy reflect poor treatment response in association with IL-6 in serum and local tumor site in patients with advanced esophageal_cancer .
22983415	0	IL-6	31,35	CRP	61,64	IL-6	CRP	3569	1401	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Significance of interleukin-6 -LRB- IL-6 -RRB- and C-reactive_protein -LRB- CRP -RRB- in children and young adults with febrile_neutropenia during chemotherapy for cancer : a prospective study .
23763486	0	IL-6	37,41	CRP	66,69	IL-6	CRP	16193(Tax:10090)	12944(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Acrolein stimulates the synthesis of IL-6 and C-reactive_protein -LRB- CRP -RRB- in thrombosis model mice and cultured cells .
25671204	0	IL-6	52,56	CRP	82,85	IL-6	CRP	3569	1401	Gene	Gene	Interleukin-6|appos|START_ENTITY Interleukin-6|appos|END_ENTITY	Effect of different training mode on Interleukin-6 -LRB- IL-6 -RRB- and C-reactive_protein -LRB- CRP -RRB- in type_2_diabetes_mellitus -LRB- T2DM -RRB- patients .
26520627	0	IL-6	20,24	CRP	26,29	IL-6	CRP	3569	1401	Gene	Gene	WBC|compound|START_ENTITY WBC|appos|END_ENTITY	Diagnostic Value of IL-6 , CRP , WBC , and Absolute Neutrophil Count to Predict Serious Bacterial_Infection in Febrile Infants .
16626811	0	IL-6	0,4	CSF	24,27	IL-6	CSF	3569	1437	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	IL-6 and CCL2 levels in CSF are associated with the clinical course of MS : implications for their possible immunopathogenic roles .
23227240	0	IL-6	15,19	CTGF	0,4	IL-6	CTGF	3569	1490	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway .
22269426	0	IL-6	26,30	CXCL1	0,5	IL-6	CXCL1	16193(Tax:10090)	14825(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis .
22791336	0	IL-6	12,16	CXCL1	42,47	IL-6	CXCL1	16193(Tax:10090)	14825(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|lung_injury lung_injury|nmod|production production|compound|END_ENTITY	Circulating IL-6 mediates lung_injury via CXCL1 production after acute_kidney_injury in mice .
17392576	0	IL-6	182,186	CXCL8	188,193	IL-6	CXCL8	3569	3576	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
18310089	0	IL-6	30,34	CXCR4	47,52	IL-6	CXCR4	3569	7852	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Bone-derived SDF-1 stimulates IL-6 release via CXCR4 , ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral_cancer cells .
21312239	0	IL-6	45,49	CXCR4	30,35	IL-6	CXCR4	3569	7852	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	Stromal cell-derived factor-1 / CXCR4 promotes IL-6 production in human synovial fibroblasts .
14962494	0	IL-6	98,102	Calcitonin_gene-related_peptide	0,31	IL-6	Calcitonin gene-related peptide	3569	796	Gene	Gene	induction|nmod|START_ENTITY inhibits|nmod|induction inhibits|nsubj|END_ENTITY	Calcitonin_gene-related_peptide indirectly inhibits IL-7 responses in pre-B cells by induction of IL-6 and TNF-alpha in bone marrow .
7671321	0	IL-6	58,62	Calcitonin_gene-related_peptide	0,31	IL-6	Calcitonin gene-related peptide	3569	796	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Calcitonin_gene-related_peptide enhances cytokine-induced IL-6 production by fibroblasts .
23695883	0	IL-6	55,59	Cia4	25,29	IL-6	Cia4	24498(Tax:10116)	140550(Tax:10116)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Arthritis severity locus Cia4 is an early regulator of IL-6 , IL-1b , and NF-kB activators ' expression in pristane-induced_arthritis .
11602623	0	IL-6	42,46	Corticotropin-releasing_hormone	0,31	IL-6	Corticotropin-releasing hormone	16193(Tax:10090)	12918(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone regulates IL-6 expression during inflammation .
25927423	0	IL-6	0,4	CsA	93,96	IL-6	CsA	3569	1161	Gene	Gene	Family|compound|START_ENTITY Family|nmod|END_ENTITY	IL-6 Family of Cytokines in Crevicular Fluid of Renal Transplant Recipients With and Without CsA - Induced Gingival_Overgrowth .
8484104	0	IL-6	66,70	Cyclosporin_A	0,13	IL-6	Cyclosporin A	16193(Tax:10090)	71991(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibit|dobj|secretion inhibit|nsubj|END_ENTITY	Cyclosporin_A does not inhibit IL-1 alpha-induced epithelial cell IL-6 secretion .
22547695	0	IL-6	14,18	Cyr61	0,5	IL-6	Cyr61	3569	3491	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Cyr61 induces IL-6 production by fibroblast-like synoviocytes promoting Th17 differentiation in rheumatoid_arthritis .
22951300	0	IL-6	34,38	D-dopachrome_tautomerase	0,24	IL-6	D-dopachrome tautomerase	3569	1652	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	D-dopachrome_tautomerase promotes IL-6 expression and inhibits adipogenesis in preadipocytes .
23533581	0	IL-6	31,35	DNA-PKcs	15,23	IL-6	DNA-PKcs	3569	5591	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Involvement of DNA-PKcs in the IL-6 and IL-12 response to CpG-ODN is mediated by its interaction with TRAF6 in dendritic cells .
11028659	0	IL-6	22,26	ERK	81,84	IL-6	ERK	3569	5594	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nmod|END_ENTITY	Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK - and p38_MAPK-dependent mechanisms .
11597988	0	IL-6	110,114	ERK	0,3	IL-6	ERK	3569	5594	Gene	Gene	induction|nmod|START_ENTITY involved|nmod|induction involved|nsubj|END_ENTITY	ERK and p38 MAPK , but not NF-kappaB , are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin_II in cardiac fibroblasts .
17761160	0	IL-6	51,55	ERK	31,34	IL-6	ERK	3569	5594	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes .
21081304	0	IL-6	21,25	ERK	26,29	IL-6	ERK	3569	5594	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|dep|END_ENTITY	Relationship between IL-6 / ERK and NF-kB : a study in normal and pathological human prostate gland .
21263382	0	IL-6	0,4	ERK	98,101	IL-6	ERK	16193(Tax:10090)	26413(Tax:10090)	Gene	Gene	stem|nsubj|START_ENTITY stem|nmod|- -|compound|END_ENTITY	IL-6 and TGF-a costimulate mesenchymal stem cell vascular_endothelial_growth_factor production by ERK - , JNK - , and PI3K-mediated mechanisms .
21469095	0	IL-6	56,60	ERK	90,93	IL-6	ERK	16193(Tax:10090)	26413(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|nmod|activation activation|compound|END_ENTITY	Histamine H receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation .
24650887	0	IL-6	138,142	ERK1/2	194,200	IL-6	ERK1/2	16193(Tax:10090)	26417;26413	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|p-c-JUN_and_JNK p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
16161448	0	IL-6	39,43	ET-1	51,55	IL-6	ET-1	24498(Tax:10116)	24323(Tax:10116)	Gene	Gene	liquid|nmod|START_ENTITY liquid|amod|END_ENTITY	-LSB- Influence of Minkeqing oral liquid on IL-6 , IL-8 , ET-1 , TX-B2 in blood and to observe bronchoalveolar lavage fluid of the rat with inhalating ovalbumin -RSB- .
8897812	0	IL-6	13,17	ET-1	0,4	IL-6	ET-1	3569	1906	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	ET-1 induces IL-6 gene expression in human umbilical vein endothelial cells : synergistic effect of IL-1 .
18490709	0	IL-6	114,118	Foxp3	14,19	IL-6	Foxp3	3569	50943	Gene	Gene	resistant|nmod|START_ENTITY +|ccomp|resistant +|nsubj|CD25 CD25|compound|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
1893964	0	IL-6	63,67	G-CSF	101,106	IL-6	G-CSF	3569	1440	Gene	Gene	IL-1|nmod|START_ENTITY interleukins|dep|IL-1 interleukins|dep|END_ENTITY	Rapid and sensitive mRNA phenotyping for interleukins -LRB- IL-1 to IL-6 -RRB- and colony-stimulating factors -LRB- G-CSF , M-CSF , and GM-CSF -RRB- by reverse transcription and subsequent polymerase chain reaction .
23630344	0	IL-6	0,4	G-CSF	21,26	IL-6	G-CSF	16193(Tax:10090)	12985(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|END_ENTITY	IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation .
7542536	0	IL-6	82,86	G-CSF	56,61	IL-6	G-CSF	3569	1440	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	Changes in serum granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and interleukin_6 -LRB- IL-6 -RRB- after surgical intervention .
7683506	0	IL-6	43,47	G-CSF	98,103	IL-6	G-CSF	3569	1440	Gene	Gene	interleukin_6|appos|START_ENTITY Elevation|nmod|interleukin_6 Elevation|appos|END_ENTITY	Elevation of amniotic fluid interleukin_6 -LRB- IL-6 -RRB- , IL-8 and granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in term and preterm parturition .
8554685	0	IL-6	29,33	G-CSF	41,46	IL-6	G-CSF	3569	1440	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
7692628	0	IL-6	29,33	G.CSF	11,16	IL-6	G.CSF	3569	1440	Gene	Gene	HILDA/LIF|amod|START_ENTITY HILDA/LIF|amod|END_ENTITY	HILDA/LIF , G.CSF , IL-1_beta , IL-6 , and TNF_alpha production during acute rejection of human kidney allografts .
23499806	0	IL-6	92,96	GLP-1	167,172	IL-6	GLP-1	3569	100125288	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Acute peripheral administration of synthetic human GLP-1 -LRB- 7-36 amide -RRB- decreases circulating IL-6 in obese patients with type_2_diabetes_mellitus : A potential role for GLP-1 in modulation of the diabetic pro-inflammatory state ?
10601562	0	IL-6	56,60	GM-CSF	9,15	IL-6	GM-CSF	16193(Tax:10090)	12981(Tax:10090)	Gene	Gene	production|compound|START_ENTITY upregulate|dobj|production upregulate|nsubj|levels levels|amod|END_ENTITY	Elevated GM-CSF levels in tumor bearing mice upregulate IL-6 production by B cells via a mechanism independent of TNF-alpha .
15271376	0	IL-6	20,24	GM-CSF	53,59	IL-6	GM-CSF	16193(Tax:10090)	12981(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Orally administered IL-6 induces elevated intestinal GM-CSF gene expression and splenic_CFU-GM .
23886206	0	IL-6	110,114	GM-CSF	129,135	IL-6	GM-CSF	16193(Tax:10090)	12981(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|acl|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
8552986	0	IL-6	118,122	GM-CSF	165,171	IL-6	GM-CSF	3569	1437	Gene	Gene	G-CSF|appos|START_ENTITY erythrocytes|dep|G-CSF Adhesion|nmod|erythrocytes END_ENTITY|nsubj|Adhesion	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8554685	0	IL-6	29,33	GM-CSF	48,54	IL-6	GM-CSF	3569	1437	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
11195003	0	IL-6	52,56	GP130	0,5	IL-6	GP130	3569	3572	Gene	Gene	complex|compound|START_ENTITY initiated|nmod|complex signalling|acl|initiated signalling|compound|END_ENTITY	GP130 and c-kit signalling , initiated by the sIL-6R / IL-6 complex , is insufficient to expand the primitive adult bone marrow CD34 + CD38 - pre-CFU cell .
24456369	0	IL-6	196,200	GP130	201,206	IL-6	GP130	3569	3572	Gene	Gene	interface|compound|START_ENTITY interface|compound|END_ENTITY	Drug design targeting protein-protein interactions -LRB- PPIs -RRB- using multiple ligand simultaneous docking -LRB- MLSD -RRB- and drug repositioning : discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6 / GP130 interface .
26888479	0	IL-6	39,43	GPER	0,4	IL-6	GPER	3569	2852	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	GPER negatively regulates TNFa-induced IL-6 production in human breast_cancer cells via NF-kB pathway .
20621720	0	IL-6	10,14	GRO-alpha	25,34	IL-6	GRO-alpha	3569	2919	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells .
25340554	0	IL-6	93,97	Glycoprotein_130	37,53	IL-6	Glycoprotein 130	3569	3572	Gene	Gene	Cytokines|compound|START_ENTITY Activation|nmod|Cytokines Activation|compound|END_ENTITY	The Inhibition of N-Glycosylation of Glycoprotein_130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
22457856	0	IL-6	0,4	Gp130	121,126	IL-6	gp130	3569	16195(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mutations mutations|nmod|subunits subunits|amod|END_ENTITY	IL-6 and IL-11 as markers for tumor_aggressiveness and prognosis in gastric_adenocarcinoma patients without mutations in Gp130 subunits .
20072693	0	IL-6	25,29	HGF	20,23	IL-6	HGF	3569	3082	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
3279116	1	IL-6	175,179	HGF	168,171	IL-6	HGF	3569	3569	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of leukocyte-derived HGF as IL-6 .
21520052	0	IL-6	15,19	HMGB-1	0,6	IL-6	HMGB-1	3569	3146	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	HMGB-1 induces IL-6 production in human synovial fibroblasts through c-Src , Akt and NF-kB pathways .
12207910	0	IL-6	0,4	HSP72	15,20	IL-6	HSP72	3569	3303	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	IL-6 activates HSP72 gene expression in human skeletal muscle .
20018623	0	IL-6	57,61	Heat_shock_transcription_factor_1	0,33	IL-6	Heat shock transcription factor 1	16193(Tax:10090)	15499(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Heat_shock_transcription_factor_1 inhibits expression of IL-6 through activating transcription factor 3 .
22426177	0	IL-6	51,55	HuR	0,3	IL-6	HuR	3569	1994	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HuR post-transcriptionally regulates TNF-a-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin .
22939995	0	IL-6	0,4	ICAM-1	14,20	IL-6	ICAM-1	3569	3383	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma .
10576377	0	IL-6	42,46	IFN-alpha	89,98	IL-6	IFN-alpha	3569	3439	Gene	Gene	production|nmod|START_ENTITY analysis|nmod|production predict|nsubj|analysis predict|dobj|efficacy efficacy|nmod|therapy therapy|amod|END_ENTITY	Two-dimensional analysis of production of IL-6 and TNF-alpha can predict the efficacy of IFN-alpha therapy .
11877000	0	IL-6	36,40	IFN-alpha	12,21	IL-6	IFN-alpha	3569	3439	Gene	Gene	expression|amod|START_ENTITY combined|nmod|expression END_ENTITY|acl|combined	-LSB- Effects of IFN-alpha combined with IL-6 on cell growth and related genes expression and apoptosis of bone marrow cells from CGL patients -RSB- .
1753108	0	IL-6	42,46	IFN-alpha	0,9	IL-6	IFN-alpha	3569	3439	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IFN-alpha induces autocrine production of IL-6 in myeloma cell lines .
19615438	0	IL-6	68,72	IFN-alpha	35,44	IL-6	IFN-alpha	3569	3439	Gene	Gene	role|nmod|START_ENTITY depression|dep|role depression|nmod|treatment treatment|amod|END_ENTITY	Cytokine-induced depression during IFN-alpha treatment : the role of IL-6 and sleep_quality .
8899186	0	IL-6	8,12	IFN-alpha	92,101	IL-6	IFN-alpha	3569	3439	Gene	Gene	receptors|compound|START_ENTITY Soluble|dobj|receptors lymphocytes|dep|Soluble lymphocytes|amod|END_ENTITY	Soluble IL-6 receptors -LRB- sIL-6R -RRB- in hematological patients receiving immunotherapy with IL-2 / IFN-alpha or donor lymphocytes following bone marrow transplantation .
2651521	0	IL-6	42,46	IFN-beta_2	31,41	IL-6	IFN-beta 2	3569	3569	Gene	Gene	production|dep|START_ENTITY production|nmod|END_ENTITY	Cytokine-induced production of IFN-beta_2 / IL-6 by freshly explanted human endometrial stromal cells .
10582110	0	IL-6	47,51	IFN-gamma	36,45	IL-6	IFN-gamma	3569	3458	Gene	Gene	IL-8|appos|START_ENTITY IL-8|appos|END_ENTITY	Increased expression of IL-4 , IL-5 , IFN-gamma , IL-6 , IL-8 , and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis .
11529906	0	IL-6	34,38	IFN-gamma	75,84	IL-6	IFN-gamma	3569	3458	Gene	Gene	IL-17|appos|START_ENTITY cytokines|dep|IL-17 cytokines|amod|cytokines cytokines|appos|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
11916128	0	IL-6	18,22	IFN-gamma	75,84	IL-6	IFN-gamma	3569	3458	Gene	Gene	modulated|nsubjpass|START_ENTITY modulated|nmod|END_ENTITY	Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes .
12380642	0	IL-6	92,96	IFN-gamma	48,57	IL-6	IFN-gamma	3569	3458	Gene	Gene	secretion|compound|START_ENTITY increase|nmod|secretion effects|dep|increase effects|nmod|END_ENTITY	Contrasting effects of long-term treatment with IFN-gamma in endothelial cells : increase in IL-6 secretion versus decrease in IL-8 secretion , NF-kappa_B , and AP-1 activation .
12471139	0	IL-6	20,24	IFN-gamma	0,9	IL-6	IFN-gamma	3569	3458	Gene	Gene	responses|compound|START_ENTITY amplifies|dobj|responses amplifies|nsubj|END_ENTITY	IFN-gamma amplifies IL-6 and IL-8 responses by airway epithelial-like cells via indoleamine 2,3-dioxygenase .
12954239	0	IL-6	43,47	IFN-gamma	60,69	IL-6	IFN-gamma	517016(Tax:9913)	281237(Tax:9913)	Gene	Gene	IL-1_alpha|dep|START_ENTITY IL-1_alpha|dep|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
15935883	0	IL-6	0,4	IFN-gamma	40,49	IL-6	IFN-gamma	3569	3458	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|amod|END_ENTITY	IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4 + CD25 + regulatory T cells .
16258194	0	IL-6	38,42	IFN-gamma	27,36	IL-6	IFN-gamma	3569	3458	Gene	Gene	IL-17|appos|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16428073	0	IL-6	146,150	IFN-gamma	135,144	IL-6	IFN-gamma	16193(Tax:10090)	15978(Tax:10090)	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	In vitro and in vivo effects of mercuric_chloride on thymic endocrine activity , NK and NKT cell cytotoxicity , cytokine profiles -LRB- IL-2 , IFN-gamma , IL-6 -RRB- : role of the nitric_oxide-L-arginine pathway .
18600325	0	IL-6	44,48	IFN-gamma	68,77	IL-6	IFN-gamma	3569	3458	Gene	Gene	IL-17|dep|START_ENTITY cytokines|appos|IL-17 cytokines|appos|END_ENTITY	Profile of Th17 cytokines -LRB- IL-17 , TGF-beta , IL-6 -RRB- and Th1 cytokine -LRB- IFN-gamma -RRB- in patients with immune_thrombocytopenic_purpura .
19050105	0	IL-6	50,54	IFN-gamma	0,9	IL-6	IFN-gamma	16193(Tax:10090)	15978(Tax:10090)	Gene	Gene	signal|compound|START_ENTITY regulated|nmod|signal cells|acl|regulated expression|nmod|cells expression|amod|END_ENTITY	IFN-gamma expression in CD8 + T cells regulated by IL-6 signal is involved in superantigen-mediated CD4 + T cell death .
1918983	0	IL-6	0,4	IFN-gamma	37,46	IL-6	IFN-gamma	3569	3458	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	IL-6 and IL-6 receptor modulation by IFN-gamma and tumor necrosis factor-alpha in human monocytic cell line -LRB- THP-1 -RRB- .
19225954	0	IL-6	27,31	IFN-gamma	103,112	IL-6	IFN-gamma	3569	3458	Gene	Gene	PMBC-derived|amod|START_ENTITY uninfluenced|nsubjpass|PMBC-derived uninfluenced|nmod|restoration restoration|nmod|synthesis synthesis|amod|END_ENTITY	Postoperative PMBC-derived IL-6 and TNF-alpha-release is uninfluenced by IL-12-mediated restoration of IFN-gamma synthesis .
19497133	0	IL-6	77,81	IFN-gamma	46,55	IL-6	IFN-gamma	3569	3458	Gene	Gene	baseline|nmod|START_ENTITY baseline|nmod|transduction transduction|amod|END_ENTITY	Differential baseline and response profile to IFN-gamma gene transduction of IL-6 / IL-6 receptor-alpha secretion discriminate primary_tumors versus bone marrow metastases of nasopharyngeal_carcinomas in culture .
19497133	0	IL-6	82,86	IFN-gamma	46,55	IL-6	IFN-gamma	3569	3458	Gene	Gene	receptor-alpha|compound|START_ENTITY secretion|nsubj|receptor-alpha baseline|parataxis|secretion baseline|nmod|transduction transduction|amod|END_ENTITY	Differential baseline and response profile to IFN-gamma gene transduction of IL-6 / IL-6 receptor-alpha secretion discriminate primary_tumors versus bone marrow metastases of nasopharyngeal_carcinomas in culture .
21591983	0	IL-6	47,51	IFN-gamma	53,62	IL-6	IFN-gamma	3569	3458	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
21744329	0	IL-6	67,71	IFN-gamma	85,94	IL-6	IFN-gamma	3569	3458	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
7880401	0	IL-6	48,52	IFN-gamma	18,27	IL-6	IFN-gamma	3569	3458	Gene	Gene	START_ENTITY|nsubj|Interferon-gamma Interferon-gamma|appos|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- and interleukin-6 -LRB- IL-6 -RRB- in peritoneal fluid and macrophage-conditioned media of women with endometriosis .
8543806	0	IL-6	19,23	IFN-gamma	0,9	IL-6	IFN-gamma	16193(Tax:10090)	15978(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY promotes|dobj|secretion promotes|nsubj|END_ENTITY	IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides .
9661265	0	IL-6	33,37	IFN-gamma	50,59	IL-6	IFN-gamma	100628202	396991(Tax:9823)	Gene	Gene	START_ENTITY|dep|TNF-alpha TNF-alpha|compound|END_ENTITY	Evaluation of various cytokines -LRB- IL-6 , IFN-alpha , IFN-gamma , TNF-alpha -RRB- as markers for acute bacterial_infection in swine -- a possible role for serum interleukin-6 .
9893032	0	IL-6	0,4	IFN-gamma	6,15	IL-6	IFN-gamma	24498(Tax:10116)	25712(Tax:10116)	Gene	Gene	START_ENTITY|appos|production production|amod|END_ENTITY	IL-6 , IFN-gamma and TNF-alpha production by liver-associated T cells and acute_liver_injury in rats administered concanavalin A .
21524164	0	IL-6	0,4	IFN-y	113,118	IL-6	IFN-y	3569	3458	Gene	Gene	factor|amod|START_ENTITY involved|nsubjpass|factor involved|nmod|END_ENTITY	IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage : regulation by IFN-y .
22426116	0	IL-6	0,4	IFN-y	14,19	IL-6	IFN-y	3569	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	IL-6 inhibits IFN-y induced autophagy in Mycobacterium_tuberculosis_H37Rv infected macrophages .
22707092	0	IL-6	7,11	IFN-y	26,31	IL-6	IFN-y	3569	3458	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
26066058	0	IL-6	25,29	IFN-y	123,128	IL-6	IFN-y	3569	3458	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|Associated Associated|nmod|Production Production|compound|END_ENTITY	High Pulmonary Levels of IL-6 and IL-1b in Children with Chronic_Suppurative_Lung_Disease Are Associated with Low Systemic IFN-y Production in Response to Non-Typeable Haemophilus_influenzae .
2329546	0	IL-6	14,18	IFN_beta_2	26,36	IL-6	IFN beta 2	3569	3569	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of IL-6 -LRB- BSF-2 / IFN_beta_2 -RRB- by mononuclear cells in premature and term infants .
26790609	0	IL-6	32,36	IFNa	0,4	IL-6	IFNa	3569	3438	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IFNa enhances the production of IL-6 by human neutrophils activated via TLR8 .
20631892	0	IL-6	114,118	IFNgamma	35,43	IL-6	IFNgamma	3569	3458	Gene	Gene	Pathway|compound|START_ENTITY Involvement|nmod|Pathway Activation|dep|Involvement Activation|nmod|END_ENTITY	Activation of PPARalpha Attenuates IFNgamma and IL-1beta-induced Cell Proliferation in Astrocytes : Involvement of IL-6 Independent Pathway .
22033984	0	IL-6	22,26	IGF-1	30,35	IL-6	IGF-1	3569	3479	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3 .
10201956	0	IL-6	70,74	IL-1	23,27	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY expression|acl|signaling END_ENTITY|dobj|expression	Augmentation of type I IL-1 receptor expression and IL-1 signaling by IL-6 and glucocorticoid in murine hepatocytes .
10429944	0	IL-6	11,15	IL-1	131,135	IL-6	IL-1	3569	3552	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes : comparison with IL-1 .
10537140	0	IL-6	85,89	IL-1	71,75	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY induced|dobj|synthesis involved|dep|induced involved|nmod|interleukin-1 interleukin-1|appos|END_ENTITY	Mitogen-activated protein -LRB- MAP -RRB- kinases are involved in interleukin-1 -LRB- IL-1 -RRB- - induced IL-6 synthesis in osteoblasts : modulation not of p38 MAP kinase , but of p42/p44 _ MAP_kinase by IL-1-activated protein kinase C .
11429163	0	IL-6	170,174	IL-1	100,104	IL-6	IL-1	3569	3552	Gene	Gene	transcription|nmod|START_ENTITY augmenting|dobj|transcription contributes|advcl|augmenting contributes|nmod|effect effect|nmod|END_ENTITY	CHOP , a basic leucine zipper transcriptional factor , contributes to the antiproliferative effect of IL-1 on A375 human melanoma cells through augmenting transcription of IL-6 .
11743653	0	IL-6	46,50	IL-1	40,44	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	roles|appos|START_ENTITY roles|appos|END_ENTITY	Discrete roles of cytokines , TNF-alpha , IL-1 , IL-6 in tumor promotion and cell transformation .
11780571	0	IL-6	53,57	IL-1	31,35	IL-6	IL-1	3569	3552	Gene	Gene	interleukin-6|dep|START_ENTITY interleukin-1|amod|interleukin-6 interleukin-1|appos|END_ENTITY	Serum levels of interleukin-1 -LRB- IL-1 -RRB- , interleukin-6 -LRB- IL-6 -RRB- and interleukin-8 -LRB- IL-8 -RRB- in patients treated with dental implants .
11859379	0	IL-6	60,64	IL-1	42,46	IL-6	IL-1	3569	3552	Gene	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	Evidence of an Eicosanoid Contribution to IL-1 Induction of IL-6 in Human Articular Chondrocytes .
1330001	0	IL-6	17,21	IL-1	42,46	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	The induction of IL-6 and gelatinase_B by IL-1 in mouse cell lines transformed with bovine papillomavirus : decreased production in tumorigenic cells .
1350224	0	IL-6	83,87	IL-1	59,63	IL-6	IL-1	3569	3552	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Characterization of thymic cell subpopulations involved in IL-1 - or GM-CSF-induced IL-6 production .
14568962	0	IL-6	36,40	IL-1	0,4	IL-6	IL-1	3569	3552	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	IL-1 induces vesicular secretion of IL-6 without degranulation from human mast cells .
1626472	0	IL-6	125,129	IL-1	75,79	IL-6	IL-1	3569	3552	Gene	Gene	interleukin|appos|START_ENTITY -LSB-|dep|interleukin -LSB-|nmod|cells cells|dep|interleukin interleukin|appos|END_ENTITY	-LSB- The synthesis of cytokines by human lens epithelial cells -- interleukin 1 -LRB- IL-1 -RRB- , tumor necrosis factor -LRB- TNF -RRB- interleukin 6 -LRB- IL-6 -RRB- , and epidermal_growth_factor -LRB- EGF -RRB- -RSB- .
1651782	0	IL-6	67,71	IL-1	14,18	IL-6	IL-1	3569	3553	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|properties properties|compound|END_ENTITY	Modulation of IL-1 inflammatory and immunomodulatory properties by IL-6 .
1727866	0	IL-6	0,4	IL-1	16,20	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite .
1906383	0	IL-6	151,155	IL-1	192,196	IL-6	IL-1	3569	3552	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- , tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes .
1932368	0	IL-6	73,77	IL-1	35,39	IL-6	IL-1	3569	3552	Gene	Gene	interleukin_6|appos|START_ENTITY that|nmod|interleukin_6 precedes|dobj|that precedes|nsubj|release release|nmod|interleukin-1_beta interleukin-1_beta|appos|END_ENTITY	The release of interleukin-1_beta -LRB- IL-1 -RRB- precedes that of interleukin_6 -LRB- IL-6 -RRB- in patients undergoing major surgery .
1997513	0	IL-6	110,114	IL-1	35,39	IL-6	IL-1	3569	3552	Gene	Gene	system|amod|START_ENTITY activating|dobj|system stimulates|advcl|activating stimulates|nsubj|interleukin-1 interleukin-1|appos|END_ENTITY	Trophoblast-derived interleukin-1 -LRB- IL-1 -RRB- stimulates the release of human chorionic gonadotropin by activating IL-6 and IL-6-receptor system in first trimester human trophoblasts .
2056245	0	IL-6	80,84	IL-1	74,78	IL-6	IL-1	3569	3553	Gene	Gene	TNF-alpha|appos|START_ENTITY TNF-alpha|compound|END_ENTITY	Developmental regulation of the cytokine repertoire in human macrophages : IL-1 , IL-6 , TNF-alpha , and M-CSF .
2070556	0	IL-6	49,53	IL-1	32,36	IL-6	IL-1	3569	3553	Gene	Gene	inhibitors|dep|START_ENTITY inhibitors|nsubj|increase increase|nmod|END_ENTITY	Selective and early increase of IL-1 inhibitors , IL-6 and cortisol after elective surgery .
21178846	0	IL-6	38,42	IL-1	97,101	IL-6	IL-1	3569	3553	Gene	Gene	react|nmod|START_ENTITY react|nmod|END_ENTITY	Human nucleus pulposus cells react to IL-6 : independent actions and amplification of response to IL-1 and TNF-a .
2265243	0	IL-6	75,79	IL-1	61,65	IL-6	IL-1	3569	3552	Gene	Gene	production|compound|START_ENTITY induced|dobj|production END_ENTITY|acl|induced	Transforming_growth_factor_beta downregulates interleukin-1 -LRB- IL-1 -RRB- - induced IL-6 production by human monocytes .
2294996	0	IL-6	145,149	IL-1	161,165	IL-6	IL-1	3569	3553	Gene	Gene	suppresses|compound|START_ENTITY suppresses|dep|END_ENTITY	Correlations and interactions in the production of interleukin-6 -LRB- IL-6 -RRB- , IL-1 , and tumor_necrosis_factor -LRB- TNF -RRB- in human blood mononuclear cells : IL-6 suppresses IL-1 and TNF .
2294996	0	IL-6	66,70	IL-1	161,165	IL-6	IL-1	3569	3553	Gene	Gene	production|nmod|START_ENTITY Correlations|nmod|production Correlations|dep|suppresses suppresses|dep|END_ENTITY	Correlations and interactions in the production of interleukin-6 -LRB- IL-6 -RRB- , IL-1 , and tumor_necrosis_factor -LRB- TNF -RRB- in human blood mononuclear cells : IL-6 suppresses IL-1 and TNF .
2341718	0	IL-6	0,4	IL-1	109,113	IL-6	IL-1	3569	3553	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|inducing inducing|dobj|release release|compound|END_ENTITY	IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow_cultures by inducing IL-1 release .
2358670	0	IL-6	68,72	IL-1	0,4	IL-6	IL-1	3569	3552	Gene	Gene	production|compound|START_ENTITY stimulate|dobj|production necrosis|ccomp|stimulate necrosis|nsubj|END_ENTITY	IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA .
26448147	0	IL-6	15,19	IL-1	40,44	IL-6	IL-1	3569	3552	Gene	Gene	Regulated|nsubjpass|START_ENTITY Regulated|nmod|END_ENTITY	Muscle-Derived IL-6 Is Not Regulated by IL-1 during Exercise .
26945843	0	IL-6	75,79	IL-1	70,74	IL-6	IL-1	3569	3552	Gene	Gene	axis|compound|START_ENTITY axis|dep|indicates indicates|dobj|successful successful|nmod|END_ENTITY	Reduction in C-reactive_protein indicates successful targeting of the IL-1 / IL-6 axis resulting in improved survival in early stage multiple_myeloma .
2783442	0	IL-6	16,20	IL-1	0,4	IL-6	IL-1	3569	3553	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-1 stimulates IL-6 production in endothelial cells .
2789259	0	IL-6	0,4	IL-1	29,33	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	IL-6 is a potent cofactor of IL-1 in IgM synthesis and of IL-5 in IgA synthesis .
3265677	0	IL-6	57,61	IL-1	161,165	IL-6	IL-1	3569	3553	Gene	Gene	Induction|amod|START_ENTITY Induction|dep|use use|nmod|assays assays|nmod|END_ENTITY	Induction of hybridoma_growth_factor -LRB- HGF -RRB- , identical to IL-6 , in human fibroblasts by IL-1 : use of HGF activity in specific and sensitive biological assays for IL-1 and IL-6 .
3265677	0	IL-6	57,61	IL-1	87,91	IL-6	IL-1	3569	3553	Gene	Gene	Induction|amod|START_ENTITY Induction|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	Induction of hybridoma_growth_factor -LRB- HGF -RRB- , identical to IL-6 , in human fibroblasts by IL-1 : use of HGF activity in specific and sensitive biological assays for IL-1 and IL-6 .
7561064	0	IL-6	54,58	IL-1	16,20	IL-6	IL-1	3569	3552	Gene	Gene	production|compound|START_ENTITY Contribution|nmod|production Contribution|nmod|END_ENTITY	Contribution of IL-1 , CD14 , and CD13 in the increased IL-6 production induced by in vitro monocyte-synoviocyte interactions .
7752112	0	IL-6	49,53	IL-1	103,107	IL-6	IL-1	3569	3553	Gene	Gene	Synthesis|appos|START_ENTITY process|nsubj|Synthesis process|amod|mediated mediated|amod|END_ENTITY	Synthesis of metalloproteases and interleukin_6 -LRB- IL-6 -RRB- in human osteoarthritic synovial membrane is an IL-1 mediated process .
7928300	0	IL-6	37,41	IL-1	30,34	IL-6	IL-1	3569	3553	Gene	Gene	production|compound|START_ENTITY interleukin|appos|production interleukin|appos|END_ENTITY	Differences in interleukin 1 -LRB- IL-1 -RRB- , IL-6 , tumor_necrosis_factor and IL-1_receptor_antagonist production by human monocytes stimulated with muramyl_dipeptide -LRB- MDP -RRB- and its stearoyl derivative , romurtide .
8473513	0	IL-6	31,35	IL-1	73,77	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	production|compound|START_ENTITY mediated|nsubjpass|production mediated|nmod|receptor receptor|compound|END_ENTITY	IL-1-induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 _ dihydroxyvitamin_D3 .
8742063	0	IL-6	43,47	IL-1	34,38	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	activities|compound|START_ENTITY expression|nmod|activities expression|nmod|END_ENTITY	Complementary organ expression of IL-1 vs. IL-6 and CSF-1 activities in normal and LPS-injected mice .
8897812	0	IL-6	13,17	IL-1	99,103	IL-6	IL-1	3569	3552	Gene	Gene	expression|compound|START_ENTITY expression|dep|effect effect|nmod|END_ENTITY	ET-1 induces IL-6 gene expression in human umbilical vein endothelial cells : synergistic effect of IL-1 .
9130006	0	IL-6	153,157	IL-1	141,145	IL-6	IL-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	TNF|appos|START_ENTITY TNF|compound|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1 , IL-2 , IL-6 , TNF , CSF activity in normal mice .
9575340	0	IL-6	49,53	IL-1	8,12	IL-6	IL-1	3569	3553	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis .
21173731	0	IL-6	0,4	IL-1-beta	17,26	IL-6	IL-1-beta	3569	3553	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	IL-6 , TNF-alpha , IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions .
8552986	0	IL-6	118,122	IL-1-beta	99,108	IL-6	IL-1-beta	3569	3553	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|compound|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
10219249	0	IL-6	39,43	IL-10	10,15	IL-6	IL-10	3569	3586	Gene	Gene	production|compound|START_ENTITY down-regulate|dobj|production down-regulate|nsubj|END_ENTITY	Exogenous IL-10 and IL-4 down-regulate IL-6 production by SLE-derived PBMC .
10580806	0	IL-6	110,114	IL-10	0,5	IL-6	IL-10	3569	3586	Gene	Gene	function|amod|START_ENTITY relationship|nmod|function levels|dep|relationship levels|compound|END_ENTITY	IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain_injury : relationship to IL-6 , TNF-alpha , TGF-beta1 and blood-brain barrier function .
10880248	0	IL-6	95,99	IL-10	101,106	IL-6	IL-10	16193(Tax:10090)	16153(Tax:10090)	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Innate resistance to experimental African trypanosomiasis : differences in cytokine -LRB- TNF-alpha , IL-6 , IL-10 and IL-12 -RRB- production by bone marrow-derived macrophages from resistant and susceptible mice .
11022130	0	IL-6	76,80	IL-10	49,54	IL-6	IL-10	3569	3586	Gene	Gene	interleukin-6|dep|START_ENTITY cytokines|amod|interleukin-6 END_ENTITY|nmod|cytokines	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11022130	0	IL-6	98,102	IL-10	49,54	IL-6	IL-10	3569	3586	Gene	Gene	cytokines|dep|START_ENTITY END_ENTITY|nmod|cytokines	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11179490	0	IL-6	0,4	IL-10	33,38	IL-6	IL-10	3569	3586	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	IL-6 and IFN-gamma regulation of IL-10 production by human colon_carcinoma cells .
11507020	0	IL-6	76,80	IL-10	39,44	IL-6	IL-10	16193(Tax:10090)	16153(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY increased|nmod|mice increased|nsubjpass|levels levels|compound|END_ENTITY	Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice .
11529906	0	IL-6	34,38	IL-10	92,97	IL-6	IL-10	3569	3586	Gene	Gene	IL-17|appos|START_ENTITY cytokines|dep|IL-17 cytokines|amod|cytokines cytokines|appos|IFN-gamma IFN-gamma|dep|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
12538454	0	IL-6	167,171	IL-10	107,112	IL-6	IL-10	3569	3586	Gene	Gene	tumor_necrosis_factor-alpha|advmod|START_ENTITY responses|compound|tumor_necrosis_factor-alpha responses|amod|END_ENTITY	Repeated administrations of interleukin -LRB- IL -RRB- -12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma , _ tumor_necrosis_factor-alpha , IL-6 , and IL-8 responses .
12784729	0	IL-6	118,122	IL-10	112,117	IL-6	IL-10	3569	3586	Gene	Gene	ratio|compound|START_ENTITY -RSB-|nsubj|ratio END_ENTITY|appos|-RSB-	-LSB- A case of intraocular malignant_lymphoma diagnosed by immunoglobulin gene rearrangement and translocation , and IL-10 / IL-6 ratio in the vitreous fluid -RSB- .
14737948	0	IL-6	32,36	IL-10	80,85	IL-6	IL-10	3569	3586	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Concentration of interleukin-6 -LRB- IL-6 -RRB- , interleukin-8 -LRB- IL-8 -RRB- and interleukin-10 -LRB- IL-10 -RRB- in blood serum of breast_cancer patients .
15034082	0	IL-6	100,104	IL-10	39,44	IL-6	IL-10	3569	3586	Gene	Gene	induced|nmod|START_ENTITY Recruitment|acl|induced Recruitment|nmod|END_ENTITY	Recruitment of STAT3 for production of IL-10 by colon_carcinoma cells induced by macrophage-derived IL-6 .
15848524	0	IL-6	57,61	IL-10	63,68	IL-6	IL-10	3569	3586	Gene	Gene	MCP-1|compound|START_ENTITY MCP-1|dep|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
15972146	0	IL-6	70,74	IL-10	22,27	IL-6	IL-10	3569	3586	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|nsubj|effect effect|nmod|END_ENTITY	-LSB- Regulatory effect of IL-10 on expression of tissue factor induced by IL-6 in peripheral blood mononuclear cells -RSB- .
16696312	0	IL-6	80,84	IL-10	48,53	IL-6	IL-10	3569	3586	Gene	Gene	cytokine|dobj|START_ENTITY cytokine|nsubj|levels levels|nmod|cytokine cytokine|amod|END_ENTITY	Plasma levels of the anti-inflammatory cytokine IL-10 and inflammatory cytokine IL-6 in patients with unstable_angina .
17144099	0	IL-6	44,48	IL-10	31,36	IL-6	IL-10	3569	3586	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
17392576	0	IL-6	182,186	IL-10	202,207	IL-6	IL-10	3569	3586	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|IL-13 IL-13|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
17483704	0	IL-6	21,25	IL-10	27,32	IL-6	IL-10	3569	3586	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
18218915	0	IL-6	28,32	IL-10	11,16	IL-6	IL-10	16193(Tax:10090)	16153(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of IL-10 and age on IL-6 , IL-1beta , and TNF-alpha responses in mouse skeletal and cardiac muscle to an acute inflammatory insult .
18582534	0	IL-6	32,36	IL-10	25,30	IL-6	IL-10	3569	3586	Gene	Gene	IL-4|dep|START_ENTITY IL-4|compound|END_ENTITY	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
19300393	0	IL-6	23,27	IL-10	47,52	IL-6	IL-10	3569	3586	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Epicatechin suppresses IL-6 , IL-8 and enhances IL-10 production with NF-kappaB nuclear translocation in whole blood stimulated system .
19552919	0	IL-6	74,78	IL-10	10,15	IL-6	IL-10	3569	3586	Gene	Gene	association|nmod|START_ENTITY concentrations|nmod|association concentrations|compound|END_ENTITY	Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major_depression .
19936625	0	IL-6	17,21	IL-10	31,36	IL-6	IL-10	3569	3586	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|dep|C C|appos|C/A C/A|compound|END_ENTITY	Polymorphisms of IL-6 174_G / C , IL-10 -592 C/A and risk of HIV/AIDS among North Indian population .
20055787	0	IL-6	14,18	IL-10	37,42	IL-6	IL-10	3569	3586	Gene	Gene	HSP-60|compound|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
21591983	0	IL-6	47,51	IL-10	40,45	IL-6	IL-10	3569	3586	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
22445721	0	IL-6	91,95	IL-10	96,101	IL-6	IL-10	3569	3586	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	RNAi screen in apoptotic cancer cell-stimulated human macrophages reveals co-regulation of IL-6 / IL-10 expression .
24578755	0	IL-6	33,37	IL-10	45,50	IL-6	IL-10	3569	3586	Gene	Gene	IL-8|amod|START_ENTITY Assessment|amod|IL-8 END_ENTITY|nsubj|Assessment	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
24741587	0	IL-6	112,116	IL-10	117,122	IL-6	IL-10	3569	3586	Gene	Gene	START_ENTITY|dep|axis axis|nsubj|END_ENTITY	The robust and modulated biomarker network elicited by the Plasmodium_vivax infection is mainly mediated by the IL-6 / IL-10 axis and is associated with the parasite load .
24819026	0	IL-6	60,64	IL-10	66,71	IL-6	IL-10	3569	3586	Gene	Gene	IFN-y|compound|START_ENTITY IFN-y|dep|END_ENTITY	Prognostic importance of single-nucleotide polymorphisms in IL-6 , IL-10 , TGF-b1 , IFN-y , and TNF-a genes in chronic_phase_chronic_myeloid_leukemia .
7954438	0	IL-6	146,150	IL-10	158,163	IL-6	IL-10	16193(Tax:10090)	16153(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8552986	0	IL-6	118,122	IL-10	130,135	IL-6	IL-10	3569	3586	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8708914	0	IL-6	63,67	IL-10	6,11	IL-6	IL-10	16193(Tax:10090)	16153(Tax:10090)	Gene	Gene	TNF-alpha|amod|START_ENTITY inhibits|dobj|TNF-alpha inhibits|nsubj|therapy therapy|compound|END_ENTITY	Viral IL-10 gene therapy inhibits TNF-alpha and IL-1_beta , not IL-6 , in the newborn endotoxemic mouse .
8709636	0	IL-6	115,119	IL-10	11,16	IL-6	IL-10	3569	3586	Gene	Gene	regulation|compound|START_ENTITY involved|nmod|regulation factors|acl:relcl|involved END_ENTITY|nmod|factors	Effects of IL-10 and IL-4 on LPS-induced transcription factors -LRB- AP-1 , NF-IL6 and NF-kappa_B -RRB- which are involved in IL-6 regulation .
9067532	0	IL-6	32,36	IL-10	107,112	IL-6	IL-10	3569	3586	Gene	Gene	production|compound|START_ENTITY Regulation|nmod|production sinusoidal|nsubj|Regulation sinusoidal|nmod|END_ENTITY	Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10 .
9191887	0	IL-6	149,153	IL-10	155,160	IL-6	IL-10	3569	3586	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9472657	0	IL-6	12,16	IL-10	17,22	IL-6	IL-10	3569	3586	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|dysregulation dysregulation|compound|END_ENTITY	HIV-induced IL-6 / IL-10 dysregulation of CD4 cells is associated with defective B cell help and autoantibody formation against CD4 cells .
11022130	0	IL-6	76,80	IL-11	120,125	IL-6	IL-11	3569	3589	Gene	Gene	interleukin-6|dep|START_ENTITY cytokines|amod|interleukin-6 cytokines|dep|IL-6 IL-6|appos|interleukin-11 interleukin-11|appos|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11022130	0	IL-6	98,102	IL-11	120,125	IL-6	IL-11	3569	3589	Gene	Gene	START_ENTITY|appos|interleukin-11 interleukin-11|appos|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11517162	0	IL-6	0,4	IL-11	26,31	IL-6	IL-11	3569	3589	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	IL-6 negatively regulates IL-11 production in vitro and in vivo .
17392576	0	IL-6	182,186	IL-13	209,214	IL-6	IL-13	3569	3596	Gene	Gene	IL-8|dep|START_ENTITY IL-8|appos|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
20189822	0	IL-6	115,119	IL-13	13,18	IL-6	IL-13	16193(Tax:10090)	16163(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY protease_activated_receptors|nmod|cells Induction|nmod|protease_activated_receptors Induction|nmod|production production|compound|END_ENTITY	Induction of IL-13 production and upregulation of gene expression of protease_activated_receptors in P815 cells by IL-6 .
26878649	0	IL-6	5,9	IL-15	18,23	IL-6	IL-15	3569	3600	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	High IL-6 and low IL-15 levels mark the presence of TB_infection : A preliminary study .
15059275	0	IL-6	28,32	IL-17	0,5	IL-6	IL-17	3569	3605	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-17 induces production of IL-6 and IL-8 in rheumatoid_arthritis synovial fibroblasts via NF-kappaB - and PI3-kinase/Akt-dependent pathways .
19055697	0	IL-6	148,152	IL-17	0,5	IL-6	IL-17	3569	3605	Gene	Gene	activating|dobj|START_ENTITY eliminates|advcl|activating eliminates|nsubj|END_ENTITY	IL-17 eliminates the therapeutic effects of myelin_basic_protein-induced nasal tolerance in experimental_autoimmune_encephalomyelitis by activating IL-6 .
19907660	0	IL-6	103,107	IL-17	97,102	IL-6	IL-17	3569	3605	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17 / IL-6 axis .
20083665	0	IL-6	0,4	IL-17	36,41	IL-6	IL-17	16193(Tax:10090)	16171(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|nmod|END_ENTITY	IL-6 promotes NK cell production of IL-17 during toxoplasmosis .
20351184	0	IL-6	25,29	IL-17	0,5	IL-6	IL-17	3569	3605	Gene	Gene	enhancement|nmod|START_ENTITY enhancement|compound|END_ENTITY	IL-17 enhancement of the IL-6 signaling cascade in astrocytes .
20615550	0	IL-6	91,95	IL-17	143,148	IL-6	IL-17	16193(Tax:10090)	16171(Tax:10090)	Gene	Gene	STAT3|compound|START_ENTITY STAT3|acl|signaling signaling|dobj|pathway pathway|nmod|END_ENTITY	Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6 / STAT3 signaling pathway and down-regulation of IL-17 .
22171994	0	IL-6	28,32	IL-17	0,5	IL-6	IL-17	3569	3605	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	IL-17 induces AKT-dependent IL-6 / JAK2/STAT3 activation and tumor progression in hepatocellular_carcinoma .
23862741	0	IL-6	49,53	IL-17	81,86	IL-6	IL-17	3569	3605	Gene	Gene	levels|compound|START_ENTITY Act1|nmod|levels role|nmod|Act1 induced|nsubj|role induced|nmod|stimulation stimulation|compound|END_ENTITY	The role of Act1 , a NF-kB-activating protein , in IL-6 and IL-8 levels induced by IL-17 stimulation in SW982 cells .
24379058	0	IL-6	12,16	IL-17	84,89	IL-6	IL-17	16193(Tax:10090)	16171(Tax:10090)	Gene	Gene	signal|compound|START_ENTITY Blockade|nmod|signal exacerbates|nsubj|Blockade exacerbates|dobj|acute_inflammatory_bowel_disease acute_inflammatory_bowel_disease|nmod|END_ENTITY	Blockade of IL-6 signal exacerbates acute_inflammatory_bowel_disease via inhibiting IL-17 producing in activated CD4 + Th17 population .
25040247	0	IL-6	63,67	IL-17	0,5	IL-6	IL-17	3569	3605	Gene	Gene	chemokines|amod|START_ENTITY production|nmod|chemokines stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-17 stimulates the production of the inflammatory chemokines IL-6 and IL-8 in human dental pulp fibroblasts .
26089643	0	IL-6	35,39	IL-17	29,34	IL-6	IL-17	3569	3605	Gene	Gene	STAT3/NF-kB|dep|START_ENTITY STAT3/NF-kB|compound|END_ENTITY	Inflammation , cytokines , the IL-17 / IL-6 / STAT3/NF-kB axis , and tumorigenesis .
21310253	0	IL-6	39,43	IL-17RA	0,7	IL-6	IL-17RA	16193(Tax:10090)	16172(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis .
12472176	0	IL-6	34,38	IL-18	10,15	IL-6	IL-18	3569	3606	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Effect of IL-18 on the release of IL-6 and its soluble receptors : sIL-6Ralpha and sgp130 by human neutrophils .
16154204	0	IL-6	36,40	IL-18	49,54	IL-6	IL-18	3569	3606	Gene	Gene	IL-12|dep|START_ENTITY IL-12|dep|END_ENTITY	Proinflammatory cytokine -LRB- IL-1beta , IL-6 , IL-12 , IL-18 and TNF-alpha -RRB- levels in sera of patients with subacute cutaneous lupus_erythematosus -LRB- SCLE -RRB- .
12370360	0	IL-6	28,32	IL-19	0,5	IL-6	IL-19	16193(Tax:10090)	329244(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha .
14522096	0	IL-6	44,48	IL-1B	17,22	IL-6	IL-1B	3569	3553	Gene	Gene	IL-10|dep|START_ENTITY IL-10|compound|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
8552986	0	IL-6	118,122	IL-1RA	110,116	IL-6	IL-1RA	3569	3557	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
14522096	0	IL-6	44,48	IL-1RN	24,30	IL-6	IL-1RN	3569	3557	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
10528667	0	IL-6	57,61	IL-1Ra	82,88	IL-6	IL-1Ra	3569	3557	Gene	Gene	IL-1beta|appos|START_ENTITY IL-1beta|appos|END_ENTITY	Whole blood production of monocytic cytokines -LRB- IL-1beta , IL-6 , TNF-alpha , sIL-6R , IL-1Ra -RRB- in haemodialysed patients .
12901852	0	IL-6	50,54	IL-1Ra	14,20	IL-6	IL-1Ra	3569	3557	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Intracellular IL-1Ra type 1 inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38_mitogen-activated_protein_kinase and NF-kappaB pathways .
9135739	0	IL-6	139,143	IL-1Ra	36,42	IL-6	IL-1Ra	3569	3557	Gene	Gene	induction|nmod|START_ENTITY suppresses|dobj|induction suppresses|nsubj|expression expression|nmod|receptor receptor|amod|END_ENTITY	Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10 .
1402392	0	IL-6	11,15	IL-1_alpha	48,58	IL-6	IL-1 alpha	3569	3552	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Tumor cell IL-6 gene expression is regulated by IL-1_alpha / beta and TNF_alpha : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages .
11243098	0	IL-6	36,40	IL-1_beta	25,34	IL-6	IL-1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY Expression|appos|mRNA Expression|appos|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
1335554	0	IL-6	72,76	IL-1_beta	121,130	IL-6	IL-1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	involved|nmod|START_ENTITY involved|parataxis|and and|dep|interaction interaction|nmod|END_ENTITY	A central mechanism is involved in the secretion of ACTH in response to IL-6 in rats : comparison to and interaction with IL-1_beta .
1382099	0	IL-6	43,47	IL-1_beta	125,134	IL-6	IL-1 beta	3569	3553	Gene	Gene	Production|appos|START_ENTITY Production|nmod|astrocytes astrocytes|nmod|response response|nmod|factor-alpha factor-alpha|compound|END_ENTITY	Production of hemolymphopoietic cytokines -LRB- IL-6 , IL-8 , colony-stimulating factors -RRB- by normal human astrocytes in response to IL-1_beta and tumor necrosis factor-alpha .
14580374	0	IL-6	73,77	IL-1_beta	0,9	IL-6	IL-1 beta	3569	3553	Gene	Gene	membranes|nmod|START_ENTITY apoptosis|nmod|membranes inducer|nmod|apoptosis inducer|nsubj|END_ENTITY	IL-1_beta is a better inducer of apoptosis in human fetal membranes than IL-6 .
16002736	0	IL-6	18,22	IL-1_beta	0,9	IL-6	IL-1 beta	3569	3553	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-1_beta induces IL-6 expression in human orbital fibroblasts : identification of an anatomic-site specific phenotypic attribute relevant to thyroid-associated_ophthalmopathy .
19444976	0	IL-6	11,15	IL-1_beta	0,9	IL-6	IL-1 beta	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	elevated|nsubj|START_ENTITY elevated|advmod|END_ENTITY	IL-1_beta , IL-6 , KC and MCP-1 are elevated in synovial fluid from haemophilic mice with experimentally induced haemarthrosis .
19580863	0	IL-6	45,49	IL-1_beta	8,17	IL-6	IL-1 beta	3569	3553	Gene	Gene	release|compound|START_ENTITY Role|nmod|release Role|nmod|END_ENTITY	Role of IL-1_beta and COX2 in silica-induced IL-6 release and loss of pneumocytes in co-cultures .
2265245	0	IL-6	87,91	IL-1_beta	20,29	IL-6	IL-1 beta	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	implication|nmod|START_ENTITY induces|parataxis|implication induces|nsubj|Interleukin-1_beta Interleukin-1_beta|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- induces thrombocytosis in mice : possible implication of IL-6 .
7506738	0	IL-6	49,53	IL-1_beta	67,76	IL-6	IL-1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	induction|compound|START_ENTITY mediating|dobj|induction mediating|nmod|factor-alpha factor-alpha|compound|END_ENTITY	Signal transduction pathways mediating astrocyte IL-6 induction by IL-1_beta and tumor necrosis factor-alpha .
7692628	0	IL-6	29,33	IL-1_beta	18,27	IL-6	IL-1 beta	3569	3553	Gene	Gene	HILDA/LIF|amod|START_ENTITY HILDA/LIF|amod|END_ENTITY	HILDA/LIF , G.CSF , IL-1_beta , IL-6 , and TNF_alpha production during acute rejection of human kidney allografts .
7921752	0	IL-6	120,124	IL-1_beta	34,43	IL-6	IL-1 beta	3569	3553	Gene	Gene	correlation|nmod|START_ENTITY cytokines|dep|correlation cytokines|appos|IL-6 IL-6|dep|END_ENTITY	Serum cytokines -LRB- IL-6 , TNF-alpha , IL-1_beta and IFN-gamma -RRB- in ankylosing_spondylitis : a close correlation between serum IL-6 and disease activity and severity .
8041488	0	IL-6	15,19	IL-1_beta	118,127	IL-6	IL-1 beta	3569	3553	Gene	Gene	production|appos|START_ENTITY production|dep|interactions interactions|nmod|interleukin-1_beta interleukin-1_beta|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- production and cell growth of cultured human ameningiomas : - interactions with interleukin-1_beta -LRB- IL-1_beta -RRB- and interleukin-4 -LRB- IL-4 -RRB- in vitro .
8376550	0	IL-6	56,60	IL-1_beta	101,110	IL-6	IL-1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY induce|dobj|secretion peptide|dep|induce peptide|dep|synergism synergism|nmod|END_ENTITY	Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes : synergism with IL-1_beta and TNF_alpha .
8562579	3	IL-6	525,529	IL-1_beta	508,517	IL-6	IL-1 beta	3569	3553	Gene	Gene	IL-2_receptor|dep|START_ENTITY IL-2_receptor|compound|END_ENTITY	In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls -LRB- tumor_necrosis_factor_alpha - TNF_alpha ; interleukins IL-1_beta , IL-2 , IL-6 , soluble IL-2_receptor -RRB- .
8780215	0	IL-6	15,19	IL-1_beta	91,100	IL-6	IL-1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	Interleukin-6|appos|START_ENTITY secreted|nsubjpass|Interleukin-6 secreted|nmod|injection injection|nmod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- is secreted from the brain after intracerebroventricular injection of IL-1_beta in rats .
8805054	0	IL-6	23,27	IL-1_beta	90,99	IL-6	IL-1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY secretion|nmod|cells secretion|dep|effects effects|nmod|END_ENTITY	Polarized secretion of IL-6 by IEC-6 intestinal epithelial cells : differential effects of IL-1_beta and TNF-alpha .
9032749	0	IL-6	44,48	IL-1_beta	33,42	IL-6	IL-1 beta	3569	3553	Gene	Gene	TNF-alpha|compound|START_ENTITY END_ENTITY|appos|TNF-alpha	Increase in cytokine production -LRB- IL-1_beta , IL-6 , TNF-alpha but not IFN-gamma , GM-CSF or LIF -RRB- by stimulated whole blood cells in postmenopausal_osteoporosis .
9149805	0	IL-6	206,210	IL-1_beta	170,179	IL-6	IL-1 beta	3569	3553	Gene	Gene	induction|advcl|START_ENTITY induction|nmod|END_ENTITY	Use of the acute phase serum_amyloid_A2 -LRB- SAA2 -RRB- gene promoter in the analysis of pro- and anti-inflammatory mediators : differential kinetics of SAA2 promoter induction by IL-1_beta and TNF-alpha compared to IL-6 .
9191887	0	IL-6	149,153	IL-1_beta	138,147	IL-6	IL-1 beta	3569	3553	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|compound|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9202660	0	IL-6	0,4	IL-1_beta	80,89	IL-6	IL-1 beta	3569	3553	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|nmod|stimulation stimulation|nmod|END_ENTITY	IL-6 production in human intestinal epithelial cells following stimulation with IL-1_beta is associated with activation of the transcription factor NF-kappa_B .
9289991	0	IL-6	53,57	IL-1_beta	42,51	IL-6	IL-1 beta	3569	3553	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	-LSB- Plasma contents of cytokines -LRB- TNF-alpha , IL-1_beta , IL-6 -RRB- and their clearance during continuous hemofiltration in patients with sepsis and multiple_organ_failure -RSB- .
9594206	0	IL-6	35,39	IL-1_beta	13,22	IL-6	IL-1 beta	3569	3553	Gene	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	The study of IL-1_beta , TNF-alpha , IL-6 gene expression and plasma levels on hemodialysis before and after dialyzer reuse .
9525339	0	IL-6	0,4	IL-1_or_TNF	29,40	IL-6	IL-1 or TNF	3569	3552;7124	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	IL-6 mediates the effects of IL-1_or_TNF , but not PTHrP or 1,25 -LRB- OH -RRB- 2D3 , on osteoclast-like cell formation in normal human bone_marrow_cultures .
24352037	0	IL-6	106,110	IL-1a	100,105	IL-6	IL-1a	3569	3552	Gene	Gene	loop|compound|START_ENTITY loop|amod|END_ENTITY	Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1a / IL-6 loop .
10225968	0	IL-6	65,69	IL-1alpha	11,20	IL-6	IL-1alpha	3569	3552	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Endogenous IL-1alpha from systemic_sclerosis fibroblasts induces IL-6 and PDGF-A .
19805069	0	IL-6	83,87	IL-1alpha	19,28	IL-6	IL-1alpha	3569	3552	Gene	Gene	network|compound|START_ENTITY regulator|nmod|network regulator|nsubj|END_ENTITY	Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6 / IL-8 cytokine network .
9776110	0	IL-6	49,53	IL-1alpha	38,47	IL-6	IL-1alpha	3569	3552	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
19697035	0	IL-6	59,63	IL-1b	23,28	IL-6	IL-1b	3569	3553	Gene	Gene	production|nmod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Differential effect of IL-1b and TNFa on the production of IL-6 , IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages .
21300032	0	IL-6	26,30	IL-1b	0,5	IL-6	IL-1b	3569	3553	Gene	Gene	mRNA|compound|START_ENTITY stabilizes|dobj|mRNA stabilizes|nsubj|END_ENTITY	IL-1b potently stabilizes IL-6 mRNA in human astrocytes .
21468727	0	IL-6	77,81	IL-1b	54,59	IL-6	IL-1b	3569	3553	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|expression expression|nmod|receptors receptors|nmod|response response|nmod|END_ENTITY	Increased expression of IL-1 receptors in response to IL-1b may produce more IL-6 , IL-8 , VEGF , and PGE in senescent synovial cells induced in vitro than in presenescent cells .
22079434	0	IL-6	117,121	IL-1b	155,160	IL-6	IL-1b	3569	3553	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Stimulation of inflammatory gene expression in human preadipocytes by macrophage-conditioned medium : upregulation of IL-6 production by macrophage-derived IL-1b .
22475267	0	IL-6	59,63	IL-1b	27,32	IL-6	IL-1b	3569	3553	Gene	Gene	combinations|appos|START_ENTITY /|dobj|combinations /|nsubj|Effects Effects|nmod|END_ENTITY	Effects of interleukin_1b -LRB- IL-1b -RRB- and IL-1b / interleukin_6 -LRB- IL-6 -RRB- combinations on drug metabolizing enzymes in human hepatocyte culture .
22508062	0	IL-6	0,4	IL-1b	59,64	IL-6	IL-1b	3569	3553	Gene	Gene	production|compound|START_ENTITY contribute|nsubj|production contribute|nsubj|END_ENTITY	IL-6 production stimulated by CD14 -LRB- + -RRB- monocytes-paracrined IL-1b does not contribute to the immunosuppressive activity of human umbilical cord mesenchymal stem cells .
22697788	0	IL-6	23,27	IL-1b	62,67	IL-6	IL-1b	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY modulates|nsubj|release modulates|dobj|production production|nmod|END_ENTITY	LPS-induced release of IL-6 from glia modulates production of IL-1b in a JAK2-dependent manner .
22707092	0	IL-6	7,11	IL-1b	0,5	IL-6	IL-1b	3569	3553	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|compound|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
22919282	0	IL-6	39,43	IL-1b	32,37	IL-6	IL-1b	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	cause|nsubj|START_ENTITY cause|ccomp|Constitutive Constitutive|dobj|expression expression|nmod|END_ENTITY	Constitutive over expression of IL-1b , IL-6 , NF-kB , and Stat3 is a potential cause of lung_tumorgenesis in urethane -LRB- ethyl_carbamate -RRB- induced Balb/c mice .
23886206	0	IL-6	110,114	IL-1b	103,108	IL-6	IL-1b	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24455774	0	IL-6	22,26	IL-1b	110,115	IL-6	IL-1b	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	production|compound|START_ENTITY suppresses|dobj|production suppresses|nmod|synoviocytes synoviocytes|nmod|rats rats|acl|induced induced|nmod|stimulation stimulation|compound|END_ENTITY	Scopoletin suppresses IL-6 production from fibroblast-like synoviocytes of adjuvant_arthritis rats induced by IL-1b stimulation .
24965599	0	IL-6	67,71	IL-1b	13,18	IL-6	IL-1b	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	Up-regulation|compound|START_ENTITY Associated|nmod|Up-regulation Improves|dobj|Associated Improves|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of IL-1b Improves Hypoxia-ischemia Brain Associated with IL-6 Up-regulation in Cell and Animal Models .
25239226	0	IL-6	14,18	IL-1b	0,5	IL-6	IL-1b	3569	3553	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	IL-1b Induces IL-6 production in retinal M ller cells predominantly through the activation of P38 MAPK/NF-kB signaling pathway .
25344820	0	IL-6	115,119	IL-1b	92,97	IL-6	IL-1b	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	Upregulation|compound|START_ENTITY END_ENTITY|nmod|Upregulation	Age-Associated Increase in Cytokine Production During Systemic Inflammation-II : The Role of IL-1b in Age-Dependent IL-6 Upregulation in Adipose Tissue .
25982496	7	IL-6	1089,1093	IL-1b	1082,1087	IL-4	TGF-b	287287(Tax:10116)	59086(Tax:10116)	Gene	Gene	CD40|compound|START_ENTITY END_ENTITY|appos|CD40	After LPS treatment , when compared with the KC single cultures , the expression of pro-inflammatory cytokines -LRB- IL-1b , IL-6 , MHC-II , CD40 , CD80 , and CD86 -RRB- in the coculture system was down-regulated , whereas the expression of anti-inflammatory cytokines -LRB- TGF-b , IL-4 , PGE2 , and IL-10 -RRB- was markedly increased .
25982496	7	IL-6	1089,1093	IL-1b	1082,1087	IL-4	TGF-b	287287(Tax:10116)	59086(Tax:10116)	Gene	Gene	CD40|compound|START_ENTITY END_ENTITY|appos|CD40	After LPS treatment , when compared with the KC single cultures , the expression of pro-inflammatory cytokines -LRB- IL-1b , IL-6 , MHC-II , CD40 , CD80 , and CD86 -RRB- in the coculture system was down-regulated , whereas the expression of anti-inflammatory cytokines -LRB- TGF-b , IL-4 , PGE2 , and IL-10 -RRB- was markedly increased .
10547271	0	IL-6	118,122	IL-1beta	108,116	IL-6	IL-1beta	3569	3553	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Protein kinase c-dependent pathway is critical for the production of pro-inflammatory cytokines -LRB- TNF-alpha , IL-1beta , IL-6 -RRB- .
10579318	0	IL-6	51,55	IL-1beta	113,121	IL-6	IL-1beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY levels|nmod|interleukin-6 elevated|nsubj|levels elevated|nmod|injection injection|nmod|END_ENTITY	Mechanisms by which blood levels of interleukin-6 -LRB- IL-6 -RRB- are elevated after intracerebroventricular injection of IL-1beta in the rat : neural versus humoral control .
11446462	0	IL-6	49,53	IL-1beta	19,27	IL-6	IL-1beta	3569	3553	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Regulatory role of IL-1beta in the expression of IL-6 and IL-8 in human corneal epithelial cells during Pseudomonas_aeruginosa colonization .
12233876	0	IL-6	105,109	IL-1beta	87,95	IL-6	IL-1beta	3569	3553	Gene	Gene	production|compound|START_ENTITY induced|dobj|production END_ENTITY|acl|induced	Androgen receptors in human synoviocytes and androgen regulation of interleukin_1beta -LRB- IL-1beta -RRB- induced IL-6 production : a link between hypoandrogenicity and rheumatoid_arthritis ?
12676746	0	IL-6	20,24	IL-1beta	0,8	IL-6	IL-1beta	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa_B .
12909303	0	IL-6	140,144	IL-1beta	130,138	IL-6	IL-1beta	3569	3553	Gene	Gene	IL-8|amod|START_ENTITY IL-8|amod|END_ENTITY	Approach to discriminate subgroups in multiple_sclerosis with cerebrospinal fluid -LRB- CSF -RRB- basic inflammation indices and TNF-alpha , IL-1beta , IL-6 , IL-8 .
15195698	0	IL-6	36,40	IL-1beta	19,27	IL-6	IL-1beta	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	p38_MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts .
15341921	0	IL-6	22,26	IL-1beta	0,8	IL-6	IL-1beta	3569	3553	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK , p38 and NFkappaB signaling pathways .
15383953	0	IL-6	62,66	IL-1beta	52,60	IL-6	IL-1beta	3569	3553	Gene	Gene	IFN-gamma|compound|START_ENTITY TNF-alpha|dep|IFN-gamma TNF-alpha|dep|END_ENTITY	-LSB- Evaluation of proinflammatory cytokine -LRB- TNF-alpha , IL-1beta , IL-6 , IFN-gamma -RRB- concentrations in serum and cerebrospinal fluid of patients with neuroborreliosis -RSB- .
16154204	0	IL-6	36,40	IL-1beta	26,34	IL-6	IL-1beta	3569	3553	Gene	Gene	IL-12|dep|START_ENTITY IL-12|compound|END_ENTITY	Proinflammatory cytokine -LRB- IL-1beta , IL-6 , IL-12 , IL-18 and TNF-alpha -RRB- levels in sera of patients with subacute cutaneous lupus_erythematosus -LRB- SCLE -RRB- .
16764689	0	IL-6	105,109	IL-1beta	94,102	IL-6	IL-1beta	3569	3553	Gene	Gene	responses|amod|START_ENTITY END_ENTITY|appos|responses	Pregnancy , but not the allergic status , influences spontaneous and induced interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , IL-10 and IL-12 responses .
17047289	0	IL-6	59,63	IL-1beta	21,29	IL-6	IL-1beta	3569	3553	Gene	Gene	START_ENTITY|dep|circulating circulating|dobj|END_ENTITY	Elevated circulating IL-1beta and TNF-alpha , and unaltered IL-6 in first-trimester pregnancies complicated by threatened abortion with an adverse outcome .
18060414	0	IL-6	45,49	IL-1beta	35,43	IL-6	IL-1beta	3569	3553	Gene	Gene	IL-8|compound|START_ENTITY levels|compound|IL-8 importance|appos|levels importance|nmod|END_ENTITY	The prognostic importance of serum IL-1beta , IL-6 , IL-8 and TNF-alpha levels compared to trauma scoring systems for early mortality in children with blunt_trauma .
9712106	0	IL-6	67,71	IL-1beta	46,54	IL-6	IL-1beta	3569	3553	Gene	Gene	stimulated|dobj|START_ENTITY END_ENTITY|acl|stimulated	Nitric_oxide downregulates interleukin_1beta -LRB- IL-1beta -RRB- stimulated IL-6 , IL-8 , and prostaglandin_E2 production by human chondrocytes .
12857678	0	IL-6	0,4	IL-1ra	21,27	IL-6	IL-1ra	3569	3557	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	IL-6 enhances plasma IL-1ra , IL-10 , and cortisol in humans .
22980031	0	IL-6	12,16	IL-1ra	119,125	IL-6	IL-1ra	16193(Tax:10090)	16181(Tax:10090)	Gene	Gene	treatment|compound|START_ENTITY protects|nsubj|treatment protects|nmod|autoimmune_disease autoimmune_disease|nmod|induction induction|compound|END_ENTITY	Recombinant IL-6 treatment protects mice from organ specific autoimmune_disease by IL-6 classical signalling-dependent IL-1ra induction .
22980031	0	IL-6	83,87	IL-1ra	119,125	IL-6	IL-1ra	16193(Tax:10090)	16181(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Recombinant IL-6 treatment protects mice from organ specific autoimmune_disease by IL-6 classical signalling-dependent IL-1ra induction .
10984195	0	IL-6	32,36	IL-2	8,12	IL-6	IL-2	3569	3558	Gene	Gene	elevated|dobj|START_ENTITY elevated|nsubj|END_ENTITY	Reduced IL-2 but elevated IL-4 , IL-6 , and IgE serum levels in patients with cerebral_infarction during the acute stage .
11712808	0	IL-6	21,25	IL-2	15,19	IL-6	IL-2	3569	3558	Gene	Gene	21-1|compound|START_ENTITY END_ENTITY|appos|21-1	Serial urinary IL-2 , IL-6 , IL-8 , TNFalpha , UBC , CYFRA 21-1 and NMP22 during follow-up of patients with bladder_cancer receiving intravesical BCG .
11860226	0	IL-6	30,34	IL-2	84,88	IL-6	IL-2	3569	3558	Gene	Gene	Abrogation|nmod|START_ENTITY hypersecretion|nsubj|Abrogation hypersecretion|nmod|END_ENTITY	Abrogation of surgery-induced IL-6 hypersecretion by presurgical immunotherapy with IL-2 and its importance in the prevention of postoperative_complications .
12125480	0	IL-6	25,29	IL-2	19,23	IL-6	IL-2	3569	3558	Gene	Gene	IL-10|amod|START_ENTITY IL-10|amod|END_ENTITY	Study on cytokines IL-2 , IL-6 , IL-10 in patients of chronic_allergic_rhinitis treated with acupuncture .
1303001	0	IL-6	25,29	IL-2	19,23	IL-6	IL-2	3569	3558	Gene	Gene	cells|amod|START_ENTITY -RSB-|nsubj|cells -RSB-|advcl|-LSB- -LSB-|dobj|production production|nmod|END_ENTITY	-LSB- The production of IL-2 , IL-6 in relation to the functional development of NK cells in human fetal spleens -RSB- .
1438170	0	IL-6	72,76	IL-2	67,71	IL-6	IL-2	3569	3558	Gene	Gene	chimeric|amod|START_ENTITY Overexpression|amod|chimeric Overexpression|dep|analysis analysis|nmod|END_ENTITY	Overexpression and structure -- function analysis of a bioengineered IL-2 / IL-6 chimeric lymphokine .
14522096	0	IL-6	44,48	IL-2	32,36	IL-6	IL-2	3569	3558	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
1469455	0	IL-6	27,31	IL-2	14,18	IL-6	IL-2	3569	3558	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|compound|END_ENTITY	Evaluation of IL-2 , sIL2R , IL-6 , TNF-alpha , and IL-1_beta levels in serum and CSF of patients with optic_neuritis .
17144099	0	IL-6	44,48	IL-2	38,42	IL-6	IL-2	3569	3558	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
1730872	0	IL-6	13,17	IL-2	0,4	IL-6	IL-2	3569	3558	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-2 induces IL-6 production in human monocytes .
17392576	0	IL-6	182,186	IL-2	164,168	IL-6	IL-2	3569	3558	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
18490709	0	IL-6	114,118	IL-2	60,64	IL-6	IL-2	3569	3558	Gene	Gene	resistant|nmod|START_ENTITY resistant|nsubj|cells cells|acl|induced induced|nmod|END_ENTITY	Cutting edge : Foxp3 + CD4 + CD25 + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6 .
18582534	0	IL-6	32,36	IL-2	19,23	IL-6	IL-2	3569	3558	Gene	Gene	IL-4|dep|START_ENTITY END_ENTITY|dep|IL-4	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
21786545	0	IL-6	81,85	IL-2	75,79	IL-6	IL-2	3569	3558	Gene	Gene	IL-1|dep|START_ENTITY IL-1|dep|END_ENTITY	-LSB- Clinical significance and expression of the inflammatory cytokines -LRB- IL-1 , IL-2 , IL-6 and IL-10 -RRB- in blood serum of the patients after total hip replacement -RSB- .
2295801	0	IL-6	68,72	IL-2	0,4	IL-6	IL-2	3569	3558	Gene	Gene	differentiation|nmod|START_ENTITY differentiation|nsubj|dependence dependence|compound|END_ENTITY	IL-2 dependence of the promotion of human B cell differentiation by IL-6 -LRB- BSF-2 -RRB- .
2571638	0	IL-6	0,4	IL-2	37,41	IL-6	IL-2	3569	3558	Gene	Gene	synergize|nsubj|START_ENTITY synergize|xcomp|stimulate stimulate|dobj|production production|compound|END_ENTITY	IL-6 and IL-1 synergize to stimulate IL-2 production and proliferation of peripheral T cells .
3261751	0	IL-6	89,93	IL-2	139,143	IL-6	IL-2	3569	3558	Gene	Gene	monoclonal|dobj|START_ENTITY monoclonal|nmod|END_ENTITY	Cooperation between an anti-T cell -LRB- anti-CD28 -RRB- monoclonal antibody and monocyte-produced IL-6 in the induction of T cell responsiveness to IL-2 .
8409748	0	IL-6	90,94	IL-2	84,88	IL-6	IL-2	3569	3558	Gene	Gene	synthesis|amod|START_ENTITY synthesis|amod|mRNA mRNA|nmod|END_ENTITY	Inhibition of human mononuclear cell proliferation , interleukin synthesis , mRNA for IL-2 , IL-6 , and leukotriene B4 synthesis by a lipoxygenase inhibitor .
8562579	3	IL-6	525,529	IL-2	519,523	IL-6	IL-2	3569	3558	Gene	Gene	IL-2_receptor|dep|START_ENTITY IL-2_receptor|dep|END_ENTITY	In the present study we tested the production of cytokines in CSF and serum in 16 schizophrenic patients and 10 healthy controls -LRB- tumor_necrosis_factor_alpha - TNF_alpha ; interleukins IL-1_beta , IL-2 , IL-6 , soluble IL-2_receptor -RRB- .
8640150	0	IL-6	59,63	IL-2	82,86	IL-6	IL-2	3569	3558	Gene	Gene	IL-1_beta|dep|START_ENTITY monocytes|appos|IL-1_beta monocytes|appos|END_ENTITY	-LSB- Production of selected cytokines by monocytes -LRB- IL-1_beta , IL-6 -RRB- and lymphocytes -LRB- IL-2 , IL-4 -RRB- in peripheral blood of patients with nonallergic bronchial_asthma treated with Broncho-Vaxom -RSB- .
8899186	0	IL-6	8,12	IL-2	87,91	IL-6	IL-2	3569	3558	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|patients patients|acl|receiving receiving|nmod|END_ENTITY	Soluble IL-6 receptors -LRB- sIL-6R -RRB- in hematological patients receiving immunotherapy with IL-2 / IFN-alpha or donor lymphocytes following bone marrow transplantation .
9130006	0	IL-6	153,157	IL-2	147,151	IL-6	IL-2	16193(Tax:10090)	16183(Tax:10090)	Gene	Gene	TNF|appos|START_ENTITY TNF|appos|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1 , IL-2 , IL-6 , TNF , CSF activity in normal mice .
9776110	0	IL-6	49,53	IL-2	75,79	IL-6	IL-2	3569	3558	Gene	Gene	TNF-alpha|dep|START_ENTITY pro-inflammatory|appos|TNF-alpha pro-inflammatory|appos|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
24286242	0	IL-6	43,47	IL-29	0,5	IL-6	IL-29	3569	282618	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	IL-29 enhances Toll-like receptor-mediated IL-6 and IL-8 production by the synovial fibroblasts from rheumatoid_arthritis patients .
10456670	0	IL-6	81,85	IL-3	86,90	IL-6	IL-3	3569	3562	Gene	Gene	/|compound|START_ENTITY /|amod|END_ENTITY	Megakaryocyte induced fibroblast proliferation is enhanced by costimulation with IL-6 / IL-3 and dependent on secretory and adhesion events .
12513731	0	IL-6	158,162	IL-3	153,157	IL-6	IL-3	16193(Tax:10090)	16187(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Accelerating hematopoietic recovery in allogeneic bone marrow transplantation mice by co-infusion of marrow stromal cells transduced with dual genes of IL-3 / IL-6 -RSB- .
12681965	0	IL-6	0,4	IL-3	46,50	IL-6	IL-3	3569	3562	Gene	Gene	precludes|nsubj|START_ENTITY precludes|dobj|differentiation differentiation|acl|induced induced|nmod|END_ENTITY	IL-6 precludes the differentiation induced by IL-3 on expansion of CD34 + cells from cord blood .
2064960	0	IL-6	96,100	IL-3	150,154	IL-6	IL-3	3569	3562	Gene	Gene	growth|nmod|START_ENTITY dependent|nmod|growth line|xcomp|dependent line|xcomp|dependent dependent|nmod|END_ENTITY	Establishment and characterization of a plasma_cell_leukaemia cell line dependent for growth on IL-6 and a bi-phenotypic subclone dependent upon both IL-3 and IL-6 .
7536685	0	IL-6	51,55	IL-3	45,49	IL-6	IL-3	16193(Tax:10090)	16187(Tax:10090)	Gene	Gene	acquire|nsubj|START_ENTITY expanded|ccomp|acquire expanded|nmod|END_ENTITY	Murine marrow cells expanded in culture with IL-3 , IL-6 , IL-11 , and SCF acquire an engraftment defect in normal hosts .
7871561	0	IL-6	74,78	IL-3	62,66	IL-6	IL-3	3569	3562	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
8616012	0	IL-6	79,83	IL-3	11,15	IL-6	IL-3	3569	3562	Gene	Gene	mRNA|compound|START_ENTITY regulation|nmod|mRNA involved|nmod|regulation involved|nsubj|Effects Effects|nmod|END_ENTITY	Effects of IL-3 and LPS on transcription factors involved in the regulation of IL-6 mRNA .
10076053	0	IL-6	64,68	IL-4	15,19	IL-6	IL-4	3569	3565	Gene	Gene	synthesis|nmod|START_ENTITY regulates|dobj|synthesis regulates|nsubj|Interleukin-4 Interleukin-4|appos|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- , but not IL-10 , regulates the synthesis of IL-6 , IL-8 and leukemia_inhibitory_factor by human bone marrow stromal cells .
10547270	0	IL-6	63,67	IL-4	27,31	IL-6	IL-4	3569	3565	Gene	Gene	production|amod|START_ENTITY regulation|nmod|production regulation|nmod|END_ENTITY	Differential regulation by IL-4 and IL-10 of radiation-induced IL-6 and IL-8 production and ICAM-1 expression by human endothelial cells .
10566657	0	IL-6	125,129	IL-4	118,122	IL-6	IL-4	3569	3565	Gene	Gene	increases|appos|START_ENTITY increases|appos|END_ENTITY	Effect of radioactive iodine therapy on cytokine production in Graves ' _ disease : transient increases in interleukin-4 -LRB- IL-4 -RRB- , IL-6 , IL-10 , and tumor_necrosis_factor-alpha , with longer term increases in interferon-gamma production .
10734320	0	IL-6	19,23	IL-4	0,4	IL-6	IL-4	3569	3565	Gene	Gene	production|compound|START_ENTITY regulation|nmod|production regulation|compound|END_ENTITY	IL-4 regulation of IL-6 production involves Rac/Cdc42 - and p38_MAPK-dependent pathways in keratinocytes .
11529906	0	IL-6	34,38	IL-4	86,90	IL-6	IL-4	3569	3565	Gene	Gene	IL-17|appos|START_ENTITY cytokines|dep|IL-17 cytokines|amod|cytokines cytokines|appos|IFN-gamma IFN-gamma|dep|END_ENTITY	Proinflammatory cytokines -LRB- IL-17 , IL-6 , IL-18 and IL-12 -RRB- and Th cytokines -LRB- IFN-gamma , IL-4 , IL-10 and IL-13 -RRB- in patients with allergic_asthma .
12217330	0	IL-6	13,17	IL-4	0,4	IL-6	IL-4	3569	3565	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-4 induces IL-6 and signs of allergic-type_inflammation in the nasal airways of nonallergic individuals .
12954239	0	IL-6	43,47	IL-4	94,98	IL-6	IL-4	517016(Tax:9913)	280824(Tax:9913)	Gene	Gene	IL-1_alpha|dep|START_ENTITY pro-inflammatory|appos|IL-1_alpha pro-inflammatory|appos|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
14522096	0	IL-6	44,48	IL-4	38,42	IL-6	IL-4	3569	3565	Gene	Gene	IL-10|dep|START_ENTITY IL-10|dep|END_ENTITY	Polymorphisms of IL-1B , IL-1RN , IL-2 , IL-4 , IL-6 , IL-10 , and IFN-gamma genes in the Korean population .
1478697	0	IL-6	83,87	IL-4	53,57	IL-6	IL-4	3569	3565	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|Proliferation Proliferation|nmod|lymphoma lymphoma|acl|induced induced|nmod|END_ENTITY	Proliferation of the BCL1 B cell lymphoma induced by IL-4 and IL-5 is dependent on IL-6 and GM-CSF .
16929824	0	IL-6	49,53	IL-4	37,41	IL-6	IL-4	3569	3565	Gene	Gene	tissues|dep|START_ENTITY -RSB-|nsubj|tissues -RSB-|advcl|-LSB- -LSB-|dobj|concentration concentration|nmod|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17392576	0	IL-6	182,186	IL-4	170,174	IL-6	IL-4	3569	3565	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
2118969	0	IL-6	26,30	IL-4	12,16	IL-6	IL-4	3569	3565	Gene	Gene	synthesis|compound|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Recombinant IL-4 inhibits IL-6 synthesis by adherent peripheral blood cells in vitro .
22405769	0	IL-6	146,150	IL-4	23,27	IL-6	IL-4	3569	3565	Gene	Gene	action|nmod|START_ENTITY elicit|nmod|action elicit|nsubj|cytokines cytokines|amod|END_ENTITY	Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-a on macrophages through the autocrine action of IL-6 .
24578755	0	IL-6	33,37	IL-4	27,31	IL-6	IL-4	3569	3565	Gene	Gene	IL-8|amod|START_ENTITY Assessment|amod|IL-8 Assessment|nmod|END_ENTITY	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
2967865	0	IL-6	18,22	IL-4	108,112	IL-6	IL-4	16193(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|enhances enhances|nmod|END_ENTITY	Identification of IL-6 as a T cell-derived factor that enhances the proliferative response of thymocytes to IL-4 and phorbol_myristate_acetate .
7871561	0	IL-6	74,78	IL-4	68,72	IL-6	IL-4	3569	3565	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
7954438	0	IL-6	146,150	IL-4	140,144	IL-6	IL-4	16193(Tax:10090)	16189(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|compound|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8228249	0	IL-6	30,34	IL-4	49,53	IL-6	IL-4	3569	3565	Gene	Gene	production|compound|START_ENTITY regulation|nmod|production regulation|nmod|END_ENTITY	Tissue-specific regulation of IL-6 production by IL-4 .
8440075	0	IL-6	46,50	IL-4	37,41	IL-6	IL-4	3569	3565	Gene	Gene	production|compound|START_ENTITY effect|nmod|production effect|appos|END_ENTITY	Suppressive effect of interleukin-4 -LRB- IL-4 -RRB- on IL-6 production by adherent rheumatoid synovial cells .
8554685	0	IL-6	29,33	IL-4	23,27	IL-6	IL-4	3569	3565	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Serum cytokine levels -LRB- IL-4 , IL-6 , IL-8 , G-CSF , GM-CSF -RRB- in burned patients .
8613355	0	IL-6	148,152	IL-4	36,40	IL-6	IL-4	16193(Tax:10090)	16189(Tax:10090)	Gene	Gene	producing|xcomp|START_ENTITY cells|acl|producing associated|nsubjpass|cells reveals|ccomp|associated reveals|nsubj|immunization immunization|nmod|interleukin-4 interleukin-4|appos|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8640150	0	IL-6	59,63	IL-4	88,92	IL-6	IL-4	3569	3565	Gene	Gene	IL-1_beta|dep|START_ENTITY monocytes|appos|IL-1_beta monocytes|appos|IL-2 IL-2|dep|END_ENTITY	-LSB- Production of selected cytokines by monocytes -LRB- IL-1_beta , IL-6 -RRB- and lymphocytes -LRB- IL-2 , IL-4 -RRB- in peripheral blood of patients with nonallergic bronchial_asthma treated with Broncho-Vaxom -RSB- .
8786324	0	IL-6	27,31	IL-4	69,73	IL-6	IL-4	3569	3565	Gene	Gene	transcription|compound|START_ENTITY regulation|nmod|transcription regulation|nmod|END_ENTITY	Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines .
9562370	0	IL-6	0,4	IL-4	58,62	IL-6	IL-4	3569	3565	Gene	Gene	oligonucleotides|compound|START_ENTITY inhibit|nsubj|oligonucleotides inhibit|nmod|B-lymphocytes B-lymphocytes|compound|END_ENTITY	IL-6 antisense oligonucleotides inhibit IgE production in IL-4 and anti-CD40-stimulated human B-lymphocytes .
9776110	0	IL-6	49,53	IL-4	81,85	IL-6	IL-4	3569	3565	Gene	Gene	TNF-alpha|dep|START_ENTITY pro-inflammatory|appos|TNF-alpha pro-inflammatory|appos|IL-2 IL-2|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
10489836	0	IL-6	98,102	IL-5	58,62	IL-6	IL-5	3569	3567	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|effects effects|nmod|macrophages macrophages|nmod|responses responses|compound|END_ENTITY	Modulatory effects of alveolar macrophages on CD4 + T-cell IL-5 responses correlate with IL-1beta , IL-6 , and IL-12 production .
10582110	0	IL-6	47,51	IL-5	30,34	IL-6	IL-5	3569	3567	Gene	Gene	IL-8|appos|START_ENTITY IL-8|compound|END_ENTITY	Increased expression of IL-4 , IL-5 , IFN-gamma , IL-6 , IL-8 , and TGF-beta mRNAs in maxillary mucosa of patients with chronic sinusitis .
16929824	0	IL-6	49,53	IL-5	43,47	IL-6	IL-5	3569	3567	Gene	Gene	tissues|dep|START_ENTITY tissues|compound|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17392576	0	IL-6	182,186	IL-5	176,180	IL-6	IL-5	3569	3567	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
19478959	0	IL-6	79,83	IL-5	73,77	IL-6	IL-5	3569	3567	Gene	Gene	IL-12|appos|START_ENTITY IL-12|compound|END_ENTITY	Does Toxoplasma_gondii_infection affect the levels of IgE and cytokines -LRB- IL-5 , IL-6 , IL-10 , IL-12 , and TNF-alpha -RRB- ?
21744329	0	IL-6	67,71	IL-5	61,65	IL-6	IL-5	3569	3567	Gene	Gene	IL-13|dep|START_ENTITY IL-13|compound|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
10566591	0	IL-6	19,23	IL-6	49,53	IL-6	IL-6	3569	3569	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways .
10566591	0	IL-6	49,53	IL-6	19,23	IL-6	IL-6	3569	3569	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways .
10779772	0	IL-6	0,4	IL-6	62,66	IL-6	IL-6	3569	3569	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	IL-6 receptor independent stimulation of human gp130 by viral IL-6 .
10779772	0	IL-6	62,66	IL-6	0,4	IL-6	IL-6	3569	3569	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	IL-6 receptor independent stimulation of human gp130 by viral IL-6 .
11344240	0	IL-6	149,153	IL-6	88,92	IL-6	IL-6	3569	3569	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Human breast adipocytes express interleukin-6 -LRB- IL-6 -RRB- and its receptor system : increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function .
11344240	0	IL-6	47,51	IL-6	88,92	IL-6	IL-6	3569	3569	Gene	Gene	START_ENTITY|dep|production production|compound|END_ENTITY	Human breast adipocytes express interleukin-6 -LRB- IL-6 -RRB- and its receptor system : increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function .
11344240	0	IL-6	88,92	IL-6	149,153	IL-6	IL-6	3569	3569	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Human breast adipocytes express interleukin-6 -LRB- IL-6 -RRB- and its receptor system : increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function .
11344240	0	IL-6	88,92	IL-6	47,51	IL-6	IL-6	3569	3569	Gene	Gene	production|compound|START_ENTITY END_ENTITY|dep|production	Human breast adipocytes express interleukin-6 -LRB- IL-6 -RRB- and its receptor system : increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function .
11467999	0	IL-6	0,4	IL-6	41,45	IL-6	IL-6	3569	3569	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|dep|END_ENTITY	IL-6 attenuates apoptosis , while neither IL-6 nor IL-10 affect the numbers or protease phenotype of fetal liver-derived human mast cells .
11467999	0	IL-6	41,45	IL-6	0,4	IL-6	IL-6	3569	3569	Gene	Gene	apoptosis|dep|START_ENTITY apoptosis|compound|END_ENTITY	IL-6 attenuates apoptosis , while neither IL-6 nor IL-10 affect the numbers or protease phenotype of fetal liver-derived human mast cells .
12050269	0	IL-6	18,22	IL-6	23,27	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Evidence that the IL-6 / IL-6 soluble receptor cytokine system plays a role in the increased_skeletal_sensitivity to PTH in estrogen-deficient women .
12050269	0	IL-6	23,27	IL-6	18,22	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Evidence that the IL-6 / IL-6 soluble receptor cytokine system plays a role in the increased_skeletal_sensitivity to PTH in estrogen-deficient women .
12059947	0	IL-6	10,14	IL-6	27,31	IL-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Levels of IL-6 and soluble IL-6 receptor are increased in HIV patients with a history of immune restoration_disease after HAART .
12059947	0	IL-6	27,31	IL-6	10,14	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Levels of IL-6 and soluble IL-6 receptor are increased in HIV patients with a history of immune restoration_disease after HAART .
17615159	0	IL-6	16,20	IL-6	29,33	IL-6	IL-6	3569	3569	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells : role of IL-6 mRNA stabilization and Ca2 + - dependent mechanisms .
17615159	0	IL-6	29,33	IL-6	16,20	IL-6	IL-6	3569	3569	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells : role of IL-6 mRNA stabilization and Ca2 + - dependent mechanisms .
17882702	0	IL-6	11,15	IL-6	28,32	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes .
17882702	0	IL-6	28,32	IL-6	11,15	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Effects of IL-6 and soluble IL-6 receptor on the expression of cartilage matrix proteins in human chondrocytes .
20438838	0	IL-6	16,20	IL-6	33,37	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic_fibrosis .
20438838	0	IL-6	33,37	IL-6	16,20	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic_fibrosis .
22980031	0	IL-6	12,16	IL-6	83,87	IL-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	treatment|compound|START_ENTITY protects|nsubj|treatment protects|nmod|autoimmune_disease autoimmune_disease|nmod|induction induction|compound|END_ENTITY	Recombinant IL-6 treatment protects mice from organ specific autoimmune_disease by IL-6 classical signalling-dependent IL-1ra induction .
22980031	0	IL-6	83,87	IL-6	12,16	IL-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY autoimmune_disease|nmod|induction protects|nmod|autoimmune_disease protects|nsubj|treatment treatment|compound|END_ENTITY	Recombinant IL-6 treatment protects mice from organ specific autoimmune_disease by IL-6 classical signalling-dependent IL-1ra induction .
24385201	1	IL-6	159,163	IL-6	196,200	IL-6	IL-6	3569	3569	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	An exploratory study suggests non-response to rituximab is associated with persistently high IL-6 and better clinical response to IL-6 blocking therapy .
24385201	1	IL-6	196,200	IL-6	159,163	IL-6	IL-6	3569	3569	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	An exploratory study suggests non-response to rituximab is associated with persistently high IL-6 and better clinical response to IL-6 blocking therapy .
8632663	0	IL-6	143,147	IL-6	149,153	IL-6	IL-6	3569	3569	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	Megakaryocytic differentiation of a leukemic cell line , MC3 , by phorbol_ester : induction of glycoprotein IIb/IIIa and effects on expression of IL-6 , IL-6 receptor , mpl and GATA genes .
8632663	0	IL-6	149,153	IL-6	143,147	IL-6	IL-6	3569	3569	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	Megakaryocytic differentiation of a leukemic cell line , MC3 , by phorbol_ester : induction of glycoprotein IIb/IIIa and effects on expression of IL-6 , IL-6 receptor , mpl and GATA genes .
9010274	0	IL-6	0,4	IL-6	17,21	IL-6	IL-6	3569	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	IL-6 and soluble IL-6 receptors -LRB- sIL-6R and sgp130 -RRB- in human pleural effusions : massive IL-6 production independently of underlying diseases .
9010274	0	IL-6	17,21	IL-6	0,4	IL-6	IL-6	3569	3569	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	IL-6 and soluble IL-6 receptors -LRB- sIL-6R and sgp130 -RRB- in human pleural effusions : massive IL-6 production independently of underlying diseases .
9184420	0	IL-6	70,74	IL-6	87,91	IL-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Endothelial cell protein S synthesis is upregulated by the complex of IL-6 and soluble IL-6 receptor .
9184420	0	IL-6	87,91	IL-6	70,74	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Endothelial cell protein S synthesis is upregulated by the complex of IL-6 and soluble IL-6 receptor .
9734662	0	IL-6	38,42	IL-6	43,47	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Dexamethasone plus retinoids decrease IL-6 / IL-6 receptor and induce apoptosis in myeloma cells .
9734662	0	IL-6	43,47	IL-6	38,42	IL-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Dexamethasone plus retinoids decrease IL-6 / IL-6 receptor and induce apoptosis in myeloma cells .
9795374	0	IL-6	127,131	IL-6	152,156	IL-6	IL-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	Crosstalk between the interleukin-6 -LRB- IL-6 -RRB- - JAK-STAT and the glucocorticoid-nuclear receptor pathway : synergistic activation of IL-6 response element by IL-6 and glucocorticoid .
9795374	0	IL-6	152,156	IL-6	127,131	IL-6	IL-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	element|nmod|START_ENTITY element|compound|END_ENTITY	Crosstalk between the interleukin-6 -LRB- IL-6 -RRB- - JAK-STAT and the glucocorticoid-nuclear receptor pathway : synergistic activation of IL-6 response element by IL-6 and glucocorticoid .
10722865	0	IL-6	84,88	IL-6R	46,51	IL-6	IL-6R	3569	3570	Gene	Gene	respond|nmod|START_ENTITY respond|nsubj|line line|nummod|END_ENTITY	Soluble interleukin-6_receptor -LRB- sIL-6R -RRB- makes IL-6R negative T cell line respond to IL-6 ; it inhibits TNF production .
10976001	0	IL-6	3,7	IL-6R	31,36	IL-6	IL-6R	3569	3570	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|protein protein|amod|IL-6_soluble_receptor IL-6_soluble_receptor|dep|END_ENTITY	An IL-6 / IL-6_soluble_receptor -LRB- IL-6R -RRB- hybrid protein -LRB- H-IL-6 -RRB- induces EPO-independent erythroid differentiation in human CD34 -LRB- + -RRB- cells .
12476893	0	IL-6	37,41	IL-6R	42,47	IL-6	IL-6R	3569	3570	Gene	Gene	corticosteroids|nmod|START_ENTITY influence|nmod|corticosteroids -LSB-|dobj|influence system|dep|-LSB- system|compound|END_ENTITY	-LSB- The influence of corticosteroids on IL-6 / IL-6R system in patients with Graves ' _ ophthalmopathy -RSB- .
12553555	0	IL-6	32,36	IL-6R	66,71	IL-6	IL-6R	3569	3570	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Co-expression of interleukin-6 -LRB- IL-6 -RRB- and interleukin-6_receptor -LRB- IL-6R -RRB- in thyroid nodules is associated with co-expression of CD30_ligand / CD30 receptor .
12578631	0	IL-6	15,19	IL-6R	20,25	IL-6	IL-6R	3569	3570	Gene	Gene	Strategy|nmod|START_ENTITY -LSB-|dobj|Strategy Treatment|dep|-LSB- Treatment|compound|END_ENTITY	-LSB- A Strategy of IL-6 / IL-6R System Mediates Targeted Treatment for Leukemia -RSB- An inevitable trend for the development of new treatment of leukemia is to use targeted strategy .
15345308	0	IL-6	111,115	IL-6R	116,121	IL-6	IL-6R	3569	3570	Gene	Gene	gp130|nmod|START_ENTITY Development|nmod|gp130 Development|dep|complex complex|compound|END_ENTITY	Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6 / IL-6R complex and its competitive inhibition .
16257998	0	IL-6	90,94	IL-6R	95,100	IL-6	IL-6R	3569	3570	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	All-trans_retinoic_acid modulates radiation-induced proliferation of lung fibroblasts via IL-6 / IL-6R system .
16732516	0	IL-6	102,106	IL-6R	107,112	IL-6	IL-6R	3569	3570	Gene	Gene	/|amod|START_ENTITY pathways|amod|/ pathways|compound|END_ENTITY	Chrysin inhibits lipopolysaccharide-induced angiogenesis via down-regulation of VEGF/VEGFR -2 -LRB- KDR -RRB- and IL-6 / IL-6R pathways .
18337485	0	IL-6	0,4	IL-6R	5,10	IL-6	IL-6R	16193(Tax:10090)	16194(Tax:10090)	Gene	Gene	START_ENTITY|appos|plays plays|nsubj|axis axis|compound|END_ENTITY	IL-6 / IL-6R axis plays a critical role in acute_kidney_injury .
20083667	0	IL-6	79,83	IL-6R	20,25	IL-6	IL-6R	16193(Tax:10090)	16194(Tax:10090)	Gene	Gene	trans|compound|START_ENTITY role|nmod|trans underlines|dobj|role underlines|nsubj|Loss Loss|nmod|expression expression|compound|END_ENTITY	Loss of CD4 + T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells .
22469658	0	IL-6	8,12	IL-6R	70,75	IL-6	IL-6R	503562(Tax:31033)	101069438	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|signaling signaling|nmod|END_ENTITY	Teleost IL-6 promotes antibody production through STAT3 signaling via IL-6R and gp130 .
23658720	0	IL-6	9,13	IL-6R	14,19	IL-6	IL-6R	3569	3570	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|signaling signaling|compound|END_ENTITY	Enhanced IL-6 / IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells .
25856562	0	IL-6	36,40	IL-6R	66,71	IL-6	IL-6R	3569	3570	Gene	Gene	interleukin-6|appos|START_ENTITY effects|nmod|interleukin-6 /|nsubj|effects /|dobj|END_ENTITY	Antitumor effects of interleukin-6 -LRB- IL-6 -RRB- / interleukin-6_receptor -LRB- IL-6R -RRB- signaling pathway inhibition in clear_cell_carcinoma_of_the_ovary .
26616855	0	IL-6	33,37	IL-6R	38,43	IL-6	IL-6R	3569	3570	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|parataxis|induces induces|nsubj|signaling signaling|compound|END_ENTITY	Diacerein-mediated inhibition of IL-6 / IL-6R signaling induces apoptotic effects on breast_cancer .
26929249	0	IL-6	84,88	IL-6R	57,62	IL-6	IL-6R	3569	3570	Gene	Gene	STAT3|compound|START_ENTITY inhibits|dobj|STAT3 inhibits|nsubj|Chikusetsusaponin Chikusetsusaponin|appos|antagonist antagonist|compound|END_ENTITY	Chikusetsusaponin a butyl_ester -LRB- CS - ___ a-Be -RRB- , a novel IL-6R antagonist , inhibits IL-6 / STAT3 signaling pathway and induces cancer cell apoptosis .
8180786	0	IL-6	29,33	IL-6R	63,68	IL-6	IL-6R	24498(Tax:10116)	24499(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Expression of interleukin-6 -LRB- IL-6 -RRB- and interleukin-6_receptor -LRB- IL-6R -RRB- mRNAs in rat brain during postnatal development .
8510817	0	IL-6	42,46	IL-6R	76,81	IL-6	IL-6R	24498(Tax:10116)	24499(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Differential expression of interleukin-6 -LRB- IL-6 -RRB- and interleukin-6_receptor -LRB- IL-6R -RRB- mRNAs in rat hypothalamus .
8816254	0	IL-6	39,43	IL-6R	64,69	IL-6	IL-6R	24498(Tax:10116)	24499(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Postnatal expression of interleukin-6 -LRB- IL-6 -RRB- and IL-6_receptor -LRB- IL-6R -RRB- mRNAs in rat sympathetic and sensory ganglia .
9651120	0	IL-6	44,48	IL-6R	73,78	IL-6	IL-6R	24498(Tax:10116)	24499(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	The expressions of mRNAs for interleukin-6 -LRB- IL-6 -RRB- and the IL-6_receptor -LRB- IL-6R -RRB- in the rat hypothalamus and midbrain during restraint stress .
26484199	0	IL-6	89,93	IL-6Ra	94,100	IL-6	IL-6Ra	3569	3570	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6 / IL-6Ra axis .
26561568	0	IL-6	16,20	IL-6Ra	57,63	IL-6	IL-6Ra	16193(Tax:10090)	16194(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cleavage cleavage|nmod|END_ENTITY	ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Ra from the cell surface of leukocytes during inflammatory responses .
27097661	0	IL-6	51,55	IL-6Ra	68,74	IL-6	IL-6Ra	16193(Tax:10090)	16194(Tax:10090)	Gene	Gene	Receptor|compound|START_ENTITY END_ENTITY|nsubj|Receptor	Preproglucagon -LRB- PPG -RRB- neurons in the hindbrain have IL-6 Receptor a -LRB- IL-6Ra -RRB- and show Ca2 + influx in response to IL-6 .
21700295	0	IL-6	22,26	IL-6_receptor	39,52	IL-6	IL-6 receptor	3569	3570	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Association of plasma IL-6 and soluble IL-6_receptor levels with the Asp358Ala polymorphism of the IL-6_receptor gene in schizophrenic patients .
23136552	0	IL-6	0,4	IL-6_receptor	37,50	IL-6	IL-6 receptor	3569	3570	Gene	Gene	trans-signaling|compound|START_ENTITY trans-signaling|nmod|END_ENTITY	IL-6 trans-signaling via the soluble IL-6_receptor : importance for the pro-inflammatory activities of IL-6 .
7954438	0	IL-6	146,150	IL-7	152,156	IL-6	IL-7	16193(Tax:10090)	16196(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
10843719	0	IL-6	119,123	IL-8	125,129	IL-6	IL-8	3569	3576	Gene	Gene	IL-15|compound|START_ENTITY IL-15|dep|END_ENTITY	Increased CD40 expression on muscle cells of polymyositis and dermatomyositis : role of CD40-CD40_ligand interaction in IL-6 , IL-8 , IL-15 , and monocyte_chemoattractant_protein-1 production .
12382118	0	IL-6	14,18	IL-8	48,52	IL-6	IL-8	3569	3576	Gene	Gene	production|compound|START_ENTITY production|nmod|production production|compound|END_ENTITY	PKC-dependent IL-6 production and inhibition of IL-8 production by PKC activation in normal human skin fibroblasts under extremely high hydrostatic pressure .
12938511	0	IL-6	30,34	IL-8	24,28	IL-6	IL-8	3569	3576	Gene	Gene	IL-2|dep|START_ENTITY IL-2|compound|END_ENTITY	Effect of Sinomenine on IL-8 , IL-6 , IL-2 produced by peripheral blood mononuclear cells .
1382099	4	IL-6	750,754	IL-8	756,760	IL-6	IL-8	3569	3576	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|dep|END_ENTITY	On exposure of human astrocytes to IL-1_beta , high levels of IL-6 , IL-8 , M-CSF , G-CSF , and GM-CSF mRNAs were detected ; moreover , active secretion of all the above cytokines was demonstrated .
15072962	0	IL-6	106,110	IL-8	95,99	IL-6	IL-8	3569	3576	Gene	Gene	influenced|nmod|START_ENTITY influenced|nsubjpass|END_ENTITY	Cytokine gene expression in human skeletal muscle during concentric contraction : evidence that IL-8 , like IL-6 , is influenced by glycogen availability .
15298427	0	IL-6	113,117	IL-8	119,123	IL-6	IL-8	3569	3576	Gene	Gene	IL-10|amod|START_ENTITY IL-10|amod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
16258194	0	IL-6	38,42	IL-8	44,48	IL-6	IL-8	3569	3576	Gene	Gene	IL-17|appos|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16929824	0	IL-6	49,53	IL-8	55,59	IL-6	IL-8	3569	3576	Gene	Gene	tissues|dep|START_ENTITY tissues|amod|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17012372	0	IL-6	78,82	IL-8	72,76	IL-6	IL-8	3569	3576	Gene	Gene	JNK|appos|START_ENTITY JNK|compound|END_ENTITY	Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8 , IL-6 , ERK1/2 , JNK , and NF-kappaB activation in a cystic fibrosis epithelial cell line .
18799095	0	IL-6	10,14	IL-8	31,35	IL-6	IL-8	3569	3576	Gene	Gene	Cytokine|dep|START_ENTITY Cytokine|dep|END_ENTITY	Cytokine -LRB- IL-6 -RRB- and chemokine -LRB- IL-8 -RRB- gene polymorphisms among rheumatoid_arthritis patients in Taiwan .
19304283	0	IL-6	13,17	IL-8	36,40	IL-6	IL-8	3569	3576	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|secretion secretion|compound|END_ENTITY	Induction of IL-6 and inhibition of IL-8 secretion in the human airway cell line Calu-3 by urban particulate matter collected with a modified method of PM sampling .
19805069	0	IL-6	83,87	IL-8	88,92	IL-6	IL-8	3569	3576	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6 / IL-8 cytokine network .
20055787	0	IL-6	14,18	IL-8	20,24	IL-6	IL-8	3569	3576	Gene	Gene	HSP-60|compound|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
20072693	0	IL-6	25,29	IL-8	31,35	IL-6	IL-8	3569	3576	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
21122279	0	IL-6	109,113	IL-8	115,119	IL-6	IL-8	3569	3576	Gene	Gene	GM-CSF|dep|START_ENTITY GM-CSF|dep|END_ENTITY	Montelukast reduces eosinophilic inflammation by inhibiting both epithelial cell cytokine secretion -LRB- GM-CSF , IL-6 , IL-8 -RRB- and eosinophil survival .
22707092	0	IL-6	7,11	IL-8	13,17	IL-6	IL-8	3569	3576	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
22832157	0	IL-6	15,19	IL-8	21,25	IL-6	IL-8	3569	3576	Gene	Gene	CRP|compound|START_ENTITY CRP|appos|END_ENTITY	Elevated serum IL-6 , IL-8 , MCP-1 , CRP , and IFN-y levels in 10 - to 11-year-old boys with increased BMI .
23156730	0	IL-6	24,28	IL-8	30,34	IL-6	IL-8	3569	3576	Gene	Gene	Hsp72|nmod|START_ENTITY effect|nmod|Hsp72 -LSB-|dobj|effect -RSB-|advcl|-LSB- -RSB-|nsubj|expression expression|compound|END_ENTITY	-LSB- The effect of Hsp72 on IL-6 , IL-8 expression and activation of NF-kappaB in synoviocytes of rheumatoid_arthritis -RSB- .
24402554	0	IL-6	23,27	IL-8	29,33	IL-6	IL-8	3569	3576	Gene	Gene	IL-4|dep|START_ENTITY IL-4|dep|END_ENTITY	Cytokine levels -LRB- IL-4 , IL-6 , IL-8 and TGFb -RRB- as potential biomarkers of systemic_inflammatory_response in trauma patients .
25358651	0	IL-6	0,4	IL-8	6,10	IL-6	IL-8	3569	3576	Gene	Gene	START_ENTITY|amod|MMP-9 MMP-9|amod|END_ENTITY	IL-6 , IL-8 , MMP-2 , MMP-9 are overexpressed in Fanconi_anemia cells through a NF-kB/TNF-a dependent mechanism .
26994898	0	IL-6	40,44	IL-8	46,50	IL-6	IL-8	3569	3576	Gene	Gene	MCP-1|compound|START_ENTITY MCP-1|appos|END_ENTITY	Effects of Shock Waves on Expression of IL-6 , IL-8 , MCP-1 , and TNF-a Expression by Human Periodontal Ligament Fibroblasts : An In Vitro Study .
7683506	0	IL-6	43,47	IL-8	50,54	IL-6	IL-8	3569	3576	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|amod|END_ENTITY	Elevation of amniotic fluid interleukin_6 -LRB- IL-6 -RRB- , IL-8 and granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in term and preterm parturition .
7871561	0	IL-6	74,78	IL-8	80,84	IL-6	IL-8	3569	3576	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
8552986	0	IL-6	118,122	IL-8	124,128	IL-6	IL-8	3569	3576	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
9773833	0	IL-6	129,133	IL-8	135,139	IL-6	IL-8	3569	3576	Gene	Gene	beta|amod|START_ENTITY beta|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
17997171	0	IL-6	39,43	IL6ST	63,68	IL-6	IL6ST	3569	3572	Gene	Gene	transducer|compound|START_ENTITY transducer|appos|END_ENTITY	A non-conservative polymorphism in the IL-6 signal transducer -LRB- IL6ST -RRB- / gp130 is associated with myocardial_infarction in a hypertensive population .
20351305	0	IL-6	0,4	IgG	22,25	IL-6	IgG	16193(Tax:10090)	16059(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production .
15749903	0	IL-6	86,90	IkappaBNS	28,37	IL-6	IkappaBNS	16193(Tax:10090)	243910(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic_lamina_propria .
11205286	0	IL-6	27,31	Interferon-gamma	0,16	IL-6	Interferon-gamma	3569	3458	Gene	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Interferon-gamma increases IL-6 production in human glioblastoma cell lines .
8383024	0	IL-6	62,66	Interferon-gamma	0,16	IL-6	Interferon-gamma	24498(Tax:10116)	25712(Tax:10116)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Interferon-gamma stimulates the secretion of IL-1 , but not of IL-6 , by glomerular mesangial cells .
10377335	0	IL-6	71,75	Interleukin-6	0,13	IL-6	Interleukin-6	3569	3569	Gene	Gene	regulation|nmod|START_ENTITY production|dep|regulation production|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- production by astrocytes : autocrine regulation by IL-6 and the soluble IL-6 receptor .
1381679	0	IL-6	15,19	Interleukin-6	0,13	IL-6	Interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- gene expression and secretion by cytokine-stimulated human retinal pigment epithelial cells .
14521945	0	IL-6	87,91	Interleukin-6	0,13	IL-6	Interleukin-6	3569	3569	Gene	Gene	regulation|nmod|START_ENTITY production|dep|regulation production|amod|END_ENTITY	Interleukin-6 production by contracting human skeletal muscle : autocrine regulation by IL-6 .
15081444	0	IL-6	15,19	Interleukin-6	0,13	IL-6	Interleukin-6	3569	3569	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- expression and natural killer -LRB- NK -RRB- cell dysfunction and anergy in heart_failure .
22695063	0	IL-6	20,24	Interleukin-6	0,13	IL-6	Interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin-6 gene -LRB- IL-6 -RRB- : a possible role in brain morphology in the healthy adult brain .
7632810	0	IL-6	15,19	Interleukin-6	0,13	IL-6	Interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Interleukin-6 -LRB- IL-6 -RRB- levels in febrile children during maximal aplasia after bone marrow transplantation -LRB- BMT -RRB- are similar to those in children with normal hematopoiesis .
15837717	0	IL-6	91,95	Interleukin-6_receptor	0,22	IL-6	Interleukin-6 receptor	3569	3570	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Interleukin-6_receptor expression in contracting human skeletal muscle : regulating role of IL-6 .
8525439	0	IL-6	15,19	Interleukin_6	0,13	IL-6	Interleukin 6	3569	3569	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Interleukin_6 -LRB- IL-6 -RRB- levels in the monitoring of surgical trauma .
18228247	0	IL-6	27,31	JNK	56,59	IL-6	JNK	16193(Tax:10090)	26419(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation .
24752352	0	IL-6	0,4	JNK	133,136	IL-6	JNK	3569	5599	Gene	Gene	upregulates|dep|START_ENTITY upregulates|nmod|cells cells|acl|mediated mediated|nmod|pathway pathway|compound|END_ENTITY	IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 -LRB- ADAMTS-2 -RRB- in human osteosarcoma cells mediated by JNK pathway .
23846700	0	IL-6	29,33	KLF4	0,4	IL-6	KLF4	3569	9314	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification .
20375583	0	IL-6	35,39	LL-37	21,26	IL-6	LL-37	3569	820	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Host defence peptide LL-37 induces IL-6 expression in human bronchial epithelial cells by activation of the NF-kappaB signaling pathway .
20570250	0	IL-6	102,106	LL-37	36,41	IL-6	LL-37	3569	820	Gene	Gene	expression|nmod|START_ENTITY _|dobj|expression _|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the antimicrobial peptide LL-37 on Toll-like_receptors_2 - , _ 3 - _ and_4-triggered expression of IL-6 , IL-8 and CXCL10 in human gingival fibroblasts .
17565544	0	IL-6	51,55	Leptin	0,6	IL-6	Leptin	3569	3952	Gene	Gene	TNF-alpha|dep|START_ENTITY markers|appos|TNF-alpha markers|amod|END_ENTITY	Leptin , IL-10 and inflammatory markers -LRB- TNF-alpha , IL-6 and IL-8 -RRB- in pre-eclamptic , normotensive pregnant and healthy non-pregnant women .
24086566	0	IL-6	15,19	Leptin	0,6	IL-6	Leptin	3569	3952	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts .
9728091	0	IL-6	96,100	Leptin	0,6	IL-6	Leptin	16193(Tax:10090)	16846(Tax:10090)	Gene	Gene	family|compound|START_ENTITY cytokines|nmod|family typical|nmod|cytokines causes|xcomp|typical causes|nsubj|END_ENTITY	Leptin causes body weight_loss in the absence of in vivo activities typical of cytokines of the IL-6 family .
1382099	4	IL-6	750,754	M-CSF	762,767	IL-6	M-CSF	3569	1435	Gene	Gene	G-CSF|compound|START_ENTITY G-CSF|dep|END_ENTITY	On exposure of human astrocytes to IL-1_beta , high levels of IL-6 , IL-8 , M-CSF , G-CSF , and GM-CSF mRNAs were detected ; moreover , active secretion of all the above cytokines was demonstrated .
19783680	0	IL-6	30,34	MAIL	0,4	IL-6	MAIL	3569	64332	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	MAIL regulates human monocyte IL-6 production .
21591983	0	IL-6	47,51	MBL	64,67	IL-6	MBL	3569	50639	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
19817504	0	IL-6	48,52	MC4R	38,42	IL-6	MC4R	24498(Tax:10116)	25635(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|nummod|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
10644881	0	IL-6	61,65	MCP-1	23,28	IL-6	MCP-1	3569	6347	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Selective induction of MCP-1 in human mesangial cells by the IL-6 / sIL-6R complex .
18400310	0	IL-6	0,4	MCP-1	15,20	IL-6	MCP-1	3569	6347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IL-6 regulates MCP-1 , ICAM-1 and IL-6 expression in human myoblasts .
18976114	0	IL-6	149,153	MCP-1	155,160	IL-6	MCP-1	24498(Tax:10116)	100360872	Gene	Gene	glucose|appos|START_ENTITY glucose|appos|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
22683409	0	IL-6	12,16	MCP-1	65,70	IL-6	MCP-1	3569	6347	Gene	Gene	Blockade|nmod|START_ENTITY inhibited|nsubj|Blockade inhibited|dobj|production production|nmod|END_ENTITY	Blockade of IL-6 and TNF-a inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction .
22832157	0	IL-6	15,19	MCP-1	27,32	IL-6	MCP-1	3569	6347	Gene	Gene	CRP|compound|START_ENTITY CRP|appos|END_ENTITY	Elevated serum IL-6 , IL-8 , MCP-1 , CRP , and IFN-y levels in 10 - to 11-year-old boys with increased BMI .
20032397	0	IL-6	0,4	MMP-10	15,21	IL-6	MMP-10	3569	4319	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung_adenocarcinoma cell line .
21278254	0	IL-6	0,4	MMP-13	15,21	IL-6	MMP-13	3569	4322	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells .
22349830	0	IL-6	35,39	MMP-2	8,13	IL-6	MMP-2	3569	4313	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of MMP-2 in the regulation of IL-6 / Stat3 survival signaling via interaction with a5b1 integrin in glioma .
25358651	0	IL-6	0,4	MMP-2	12,17	IL-6	MMP-2	3569	4313	Gene	Gene	START_ENTITY|amod|MMP-9 MMP-9|amod|END_ENTITY	IL-6 , IL-8 , MMP-2 , MMP-9 are overexpressed in Fanconi_anemia cells through a NF-kB/TNF-a dependent mechanism .
10583232	0	IL-6	37,41	Mcl-1	0,5	IL-6	Mcl-1	3569	4170	Gene	Gene	co-regulated|nmod|START_ENTITY co-regulated|nsubjpass|END_ENTITY	Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells .
12479056	0	IL-6	0,4	Mcl-1	116,121	IL-6	Mcl-1	3569	4170	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|pathway pathway|nmod|END_ENTITY	IL-6 inhibits apoptosis of human myeloma cell line XG-7 through activation of JAK/STAT pathway and up-regulation of Mcl-1 .
17072336	0	IL-6	28,32	Mcl-1	111,116	IL-6	Mcl-1	3569	4170	Gene	Gene	loop|compound|START_ENTITY effect|nmod|loop mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate_cancer is mediated by Mcl-1 .
18497081	0	IL-6	22,26	Mcl-1	0,5	IL-6	Mcl-1	3569	4170	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late_stage_prostate_carcinoma .
21880146	0	IL-6	118,122	Mcl-1	123,128	IL-6	Mcl-1	3569	4170	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Mesothelin confers pancreatic_cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-kB activation and IL-6 / Mcl-1 overexpression .
23825534	0	IL-6	0,4	Mcl-1L	15,21	IL-6	Mcl-1L	24498(Tax:10116)	4170	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt / CREB signaling pathway in hepatocytes : implication of an anti-apoptotic role during liver_regeneration .
23974950	0	IL-6	19,23	MiR-146a	0,8	IL-6	MiR-146a	16193(Tax:10090)	387164(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264 .7 macrophage cells by inhibiting Notch1 .
7567467	0	IL-6	35,39	MyD88	25,30	IL-6	MyD88	24498(Tax:10116)	301059(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	5 ' upstream sequences of MyD88 , an IL-6 primary response gene in M1 cells : detection of functional IRF-1 and Stat factors binding sites .
15467434	0	IL-6	20,24	NF-kappaB	0,9	IL-6	NF-kappaB	3569	4790	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site , but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple_myeloma cells .
11120852	0	IL-6	14,18	NF-kappa_B	107,117	IL-6	NF-kappa B	3569	4790	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of IL-6 and IL-8 expression in rheumatoid_arthritis synovial fibroblasts : the dominant role for NF-kappa_B but not C/EBP _ beta or c-Jun .
12960348	0	IL-6	0,4	NF-kappa_B	13,23	IL-6	NF-kappa B	3569	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	IL-6 induces NF-kappa_B activation in the intestinal epithelia .
19817504	0	IL-6	48,52	NPY	27,30	IL-6	NPY	24498(Tax:10116)	24604(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
18202114	0	IL-6	0,4	NTPDase2	36,44	IL-6	NTPDase2	24498(Tax:10116)	64467(Tax:10116)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|transcription transcription|nmod|END_ENTITY	IL-6 downregulates transcription of NTPDase2 via specific promoter elements .
9548508	0	IL-6	58,62	Oncostatin_M	0,12	IL-6	Oncostatin M	3569	5008	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Oncostatin_M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells .
24631773	0	IL-6	24,28	P2Y2_receptor	0,13	IL-6	P2Y2 receptor	3569	5029	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	P2Y2_receptor represses IL-6 expression by valve interstitial cells through Akt : implication for calcific aortic_valve_disease .
17144099	0	IL-6	44,48	PDGF-B	50,56	IL-6	PDGF-B	3569	5155	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
12693944	0	IL-6	25,29	PKC_alpha	56,65	IL-6	PKC alpha	3569	5578	Gene	Gene	expression|compound|START_ENTITY mediated|nsubjpass|expression mediated|nmod|activation activation|compound|END_ENTITY	Arachidonic_acid-induced IL-6 expression is mediated by PKC_alpha activation in osteoblastic cells .
23831231	0	IL-6	38,42	Peroxiredoxin_V	0,15	IL-6	Peroxiredoxin V	3569	25824	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Peroxiredoxin_V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway .
20151299	0	IL-6	65,69	Protein_kinase_C-delta	0,22	IL-6	Protein kinase C-delta	16193(Tax:10090)	18753(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Protein_kinase_C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells .
25455130	0	IL-6	0,4	REX-1	30,35	IL-6	REX-1	3569	57455	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL-6 regulates stress-induced REX-1 expression via ATP-P2Y1 signalling in stem cells isolated from human exfoliated deciduous teeth .
11470914	0	IL-6	44,48	Rac1	0,4	IL-6	Rac1	3569	5879	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Rac1 mediates STAT3 activation by autocrine IL-6 .
23279369	0	IL-6	0,4	Rex-1	30,35	IL-6	Rex-1	3569	57455	Gene	Gene	regulated|nsubj|START_ENTITY regulated|dobj|expression expression|compound|END_ENTITY	IL-6 regulated stress-induced Rex-1 expression in stem cells from human exfoliated deciduous teeth .
27060579	0	IL-6	72,76	S100A7	0,6	IL-6	S100A7	3569	6278	Gene	Gene	secretion|compound|START_ENTITY inhibits|nmod|secretion inhibits|nsubj|END_ENTITY	S100A7 -LRB- psoriasin -RRB- inhibits human epidermal differentiation by enhanced IL-6 secretion through IkB/NF-kB signaling .
2001421	0	IL-6	63,67	SAA	138,141	IL-6	SAA	3569	6287	Gene	Gene	interleukin|amod|START_ENTITY interleukin|acl|stimulated stimulated|dobj|synthesis synthesis|nmod|C-reactive_protein C-reactive_protein|appos|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- inhibits interleukin -LRB- IL -RRB- -1 and/or IL-6 stimulated synthesis of C-reactive_protein -LRB- CRP -RRB- and serum_amyloid_A -LRB- SAA -RRB- in primary cultures of human hepatocytes .
7790046	0	IL-6	51,55	SAA	43,46	IL-6	SAA	3569	6287	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Synergistic activation of serum_amyloid_A -LRB- SAA -RRB- by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line .
11971024	0	IL-6	48,52	SHIP	0,4	IL-6	SHIP	3569	3635	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa_B activity .
14500551	0	IL-6	24,28	SMAD-2	88,94	IL-6	SMAD-2	3569	4087	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells : critical role of SMAD-2 .
12754505	0	IL-6	27,31	SOCS3	0,5	IL-6	SOCS3	16193(Tax:10090)	12702(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SOCS3 negatively regulates IL-6 signaling in vivo .
12754507	0	IL-6	0,4	SOCS3	61,66	IL-6	IL-10	3569	3586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|response response|nmod|absence absence|nmod|END_ENTITY	IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages .
15570293	0	IL-6	26,30	SOCS3	75,80	IL-6	SOCS3	16193(Tax:10090)	12702(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY induces|nsubj|production induces|dobj|expression expression|compound|END_ENTITY	Upregulated production of IL-6 , but not IL-10 , by interferon-alpha induces SOCS3 expression and attenuates STAT1 phosphorylation in myeloma cells .
16288983	0	IL-6	0,4	SOCS3	84,89	IL-6	SOCS3	16193(Tax:10090)	12702(Tax:10090)	Gene	Gene	proliferation|compound|START_ENTITY proliferation|dep|regulation regulation|nmod|END_ENTITY	IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1 : regulation by SOCS3 .
19027008	0	IL-6	69,73	SOCS3	49,54	IL-6	SOCS3	3569	9021	Gene	Gene	signaling|compound|START_ENTITY role|nmod|signaling role|nmod|regulation regulation|amod|microtubule-associated_protein_1S microtubule-associated_protein_1S|nmod|END_ENTITY	The role of microtubule-associated_protein_1S in SOCS3 regulation of IL-6 signaling .
21519345	0	IL-6	0,4	SOCS3	71,76	IL-6	SOCS3	16193(Tax:10090)	12702(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|inflammatory_disease inflammatory_disease|nmod|absence absence|nmod|END_ENTITY	IL-6 promotes acute and chronic inflammatory_disease in the absence of SOCS3 .
23238769	0	IL-6	74,78	SOCS3	46,51	IL-6	SOCS3	16193(Tax:10090)	12702(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY enhance|dobj|signals decreasing|advcl|enhance decreasing|dobj|expression expression|compound|END_ENTITY	A20 promotes liver_regeneration by decreasing SOCS3 expression to enhance IL-6 / STAT3 proliferative signals .
24244888	0	IL-6	4,8	SOCS3	49,54	IL-6	SOCS3	3569	9021	Gene	Gene	Paradox|compound|START_ENTITY Paradox|dep|Interplay Interplay|nmod|END_ENTITY	The IL-6 Paradox : Context Dependent Interplay of SOCS3 and AMPK .
24418198	0	IL-6	14,18	SOCS3	39,44	IL-6	SOCS3	3569	9021	Gene	Gene	family|compound|START_ENTITY Inhibition|nmod|family cytokines|nsubj|Inhibition cytokines|nmod|END_ENTITY	Inhibition of IL-6 family cytokines by SOCS3 .
26847351	0	IL-6	48,52	SOCS3	30,35	IL-6	SOCS3	3569	9021	Gene	Gene	mediated|nmod|START_ENTITY repression|acl|mediated repression|nmod|END_ENTITY	Transcriptional repression of SOCS3 mediated by IL-6 / STAT3 signaling via DNMT1 promotes pancreatic_cancer growth and metastasis .
17241887	0	IL-6	10,14	STAT-3	15,21	IL-6	STAT-3	3569	6774	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Sustained IL-6 / STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing .
18333366	0	IL-6	0,4	STAT-3	7,13	IL-6	STAT-3	3569	6774	Gene	Gene	START_ENTITY|appos|linking linking|nsubj|END_ENTITY	IL-6 - STAT-3 - hepcidin : linking inflammation to the iron metabolism .
18473764	0	IL-6	48,52	STAT-3	53,59	IL-6	STAT-3	3569	6774	Gene	Gene	role|nmod|START_ENTITY molecules|dep|role molecules|parataxis|signaling signaling|nsubj|trans trans|compound|END_ENTITY	Signaling molecules : the pathogenic role of the IL-6 / STAT-3 trans signaling pathway in intestinal inflammation and in colonic_cancer .
24390735	0	IL-6	26,30	STAT-3	31,37	IL-6	STAT-3	3569	6774	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	HAVCR/KIM -1 activates the IL-6 / STAT-3 pathway in clear_cell_renal_cell_carcinoma and determines tumor progression and patient outcome .
25830055	0	IL-6	25,29	STAT-3	30,36	IL-6	STAT-3	3569	6774	Gene	Gene	Signals|compound|START_ENTITY Signals|compound|END_ENTITY	Quercetin Down-regulates IL-6 / STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall - cell Lung-cancer Cell Line , A549 .
10445852	0	IL-6	51,55	STAT3	94,99	IL-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activation activation|nmod|END_ENTITY	Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3 .
10720495	0	IL-6	33,37	STAT3	93,98	IL-6	STAT3	3569	6774	Gene	Gene	cytokines|compound|START_ENTITY secretion|nmod|cytokines causes|nsubj|secretion causes|dobj|activation activation|compound|END_ENTITY	Autocrine/Paracrine secretion of IL-6 family cytokines causes angiotensin_II-induced delayed STAT3 activation .
10851053	0	IL-6	102,106	STAT3	9,14	IL-6	STAT3	3569	6774	Gene	Gene	family|compound|START_ENTITY relayed|nmod|family relayed|nsubj|Roles Roles|nmod|END_ENTITY	Roles of STAT3 in mediating the cell growth , differentiation and survival signals relayed through the IL-6 family of cytokine receptors .
11243705	0	IL-6	24,28	STAT3	137,142	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 .
11322950	0	IL-6	83,87	STAT3	72,77	IL-6	STAT3	3569	6774	Gene	Gene	stimulation|compound|START_ENTITY activation|nmod|stimulation activation|nmod|END_ENTITY	Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation .
11337018	0	IL-6	61,65	STAT3	0,5	IL-6	STAT3	3569	6774	Gene	Gene	effects|nmod|START_ENTITY exerts|nmod|effects exerts|nsubj|END_ENTITY	STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells .
11356008	0	IL-6	76,80	STAT3	31,36	IL-6	STAT3	3569	6774	Gene	Gene	respone|amod|START_ENTITY element|amod|respone transactivation|nmod|element cooperate|nmod|transactivation cooperate|nmod|END_ENTITY	c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element -LRB- IRE -RRB- .
11470914	0	IL-6	44,48	STAT3	14,19	IL-6	STAT3	3569	6774	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	Rac1 mediates STAT3 activation by autocrine IL-6 .
11710966	0	IL-6	0,4	STAT3	18,23	IL-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells .
11890706	0	IL-6	0,4	STAT3	56,61	IL-6	STAT3	3569	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|proto-oncogene proto-oncogene|nmod|END_ENTITY	IL-6 induces expression of the Fli-1 proto-oncogene via STAT3 .
12015387	0	IL-6	31,35	STAT3	59,64	IL-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	START_ENTITY|nmod|translocation translocation|compound|END_ENTITY	Selected contribution : role of IL-6 in LPS-induced nuclear STAT3 translocation in sensory circumventricular organs during fever in rats .
12360405	0	IL-6	0,4	STAT3	28,33	IL-6	STAT3	3569	6774	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells .
15034082	0	IL-6	100,104	STAT3	15,20	IL-6	STAT3	3569	6774	Gene	Gene	induced|nmod|START_ENTITY Recruitment|acl|induced Recruitment|nmod|END_ENTITY	Recruitment of STAT3 for production of IL-10 by colon_carcinoma cells induced by macrophage-derived IL-6 .
15356132	0	IL-6	0,4	STAT3	62,67	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation .
15976028	0	IL-6	0,4	STAT3	25,30	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	trans-signaling|compound|START_ENTITY trans-signaling|nmod|END_ENTITY	IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation .
16399222	0	IL-6	15,19	STAT3	61,66	IL-6	STAT3	3569	6774	Gene	Gene	production|compound|START_ENTITY production|acl|blocking blocking|dobj|activation activation|compound|END_ENTITY	Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant_soft_tissue_tumor cells .
16718380	0	IL-6	0,4	STAT3	81,86	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|dep|analysis analysis|nmod|N-domain N-domain|compound|END_ENTITY	IL-6 signaling via the STAT3/SOCS3 pathway : functional analysis of the conserved STAT3 N-domain .
17082315	0	IL-6	52,56	STAT3	27,32	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	hyperactivation|nmod|START_ENTITY hyperactivation|nsubj|consequences consequences|nmod|END_ENTITY	Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis .
17510282	0	IL-6	50,54	STAT3	17,22	IL-6	STAT3	3569	6774	Gene	Gene	accumulates|nmod|START_ENTITY accumulates|nsubj|END_ENTITY	Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB .
17822789	0	IL-6	63,67	STAT3	23,28	IL-6	STAT3	3569	6774	Gene	Gene	secretion|compound|START_ENTITY activation|nmod|secretion activation|compound|END_ENTITY	HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell .
17970038	0	IL-6	41,45	STAT3	46,51	IL-6	STAT3	3569	6774	Gene	Gene	targeting|dobj|START_ENTITY strategies|acl|targeting strategies|parataxis|cytokine cytokine|nsubj|END_ENTITY	Therapeutic strategies for targeting the IL-6 / STAT3 cytokine signaling pathway in inflammatory_bowel_disease .
18060032	0	IL-6	65,69	STAT3	44,49	IL-6	STAT3	3569	6774	Gene	Gene	production|compound|START_ENTITY activation|nmod|production activation|nummod|END_ENTITY	Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung_adenocarcinomas .
18474224	0	IL-6	4,8	STAT3	39,44	IL-6	STAT3	3569	6774	Gene	Gene	family|compound|START_ENTITY modulates|nsubj|family modulates|dobj|activation activation|compound|END_ENTITY	The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction .
18641358	0	IL-6	0,4	STAT3	68,73	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|inflammation inflammation|nmod|END_ENTITY	IL-6 regulates neutrophil trafficking during acute inflammation via STAT3 .
19109195	0	IL-6	25,29	STAT3	58,63	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	targeting|nmod|START_ENTITY trans|nsubj|targeting trans|xcomp|signaling signaling|dobj|control control|compound|END_ENTITY	Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory_arthritis .
19285962	0	IL-6	23,27	STAT3	28,33	IL-6	STAT3	3569	6774	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Capsaicin inhibits the IL-6 / STAT3 pathway by depleting intracellular gp130 pools through endoplasmic_reticulum_stress .
19330073	0	IL-6	152,156	STAT3	117,122	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	action|appos|START_ENTITY attenuate|dobj|action signal_transduction_and_activation_of_transcription_3|acl|attenuate signal_transduction_and_activation_of_transcription_3|appos|END_ENTITY	Pravastatin prevents aortic_atherosclerosis via modulation of signal_transduction_and_activation_of_transcription_3 -LRB- STAT3 -RRB- to attenuate interleukin-6 -LRB- IL-6 -RRB- action in ApoE knockout mice .
19741197	0	IL-6	0,4	STAT3	86,91	IL-6	STAT3	3569	6774	Gene	Gene	stimulates|dep|START_ENTITY stimulates|nsubj|activity activity|nmod|cells cells|nmod|END_ENTITY	IL-6 stimulates system A amino_acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2 .
19751774	0	IL-6	43,47	STAT3	17,22	IL-6	STAT3	3569	6774	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|Visfatin Visfatin|nmod|activation activation|compound|END_ENTITY	Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis .
20562100	0	IL-6	68,72	STAT3	14,19	IL-6	STAT3	3569	6774	Gene	Gene	activity|nmod|START_ENTITY blocks|dobj|activity blocks|nsubj|Inhibition Inhibition|nmod|signaling signaling|compound|END_ENTITY	Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver_cancer cells .
20818158	0	IL-6	0,4	STAT3	79,84	IL-6	STAT3	3569	6774	Gene	Gene	factor|dep|START_ENTITY factor|dep|phosphorylation phosphorylation|compound|END_ENTITY	IL-6 , a risk factor for hepatocellular_carcinoma : FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular_cancer cells .
21148800	0	IL-6	0,4	STAT3	73,78	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	trans-signaling|compound|START_ENTITY modulates|nsubj|trans-signaling modulates|dobj|responses responses|nmod|END_ENTITY	IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 .
21282107	0	IL-6	115,119	STAT3	55,60	IL-6	STAT3	3569	6774	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway END_ENTITY|nmod|cells	Extracellular hepatitis_C_virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway .
21293887	0	IL-6	0,4	STAT3	44,49	IL-6	STAT3	3569	6774	Gene	Gene	induction|compound|START_ENTITY induction|nmod|expression expression|nmod|END_ENTITY	IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle .
21619877	0	IL-6	18,22	STAT3	4,9	IL-6	STAT3	3569	6774	Gene	Gene	activates|nsubj|START_ENTITY beacon|parataxis|activates beacon|compound|END_ENTITY	The STAT3 beacon : IL-6 recurrently activates STAT_3 from endosomal structures .
21744993	0	IL-6	69,73	STAT3	42,47	IL-6	STAT3	3569	6774	Gene	Gene	EMT|compound|START_ENTITY signaling|nmod|EMT effects|acl|signaling effects|nmod|blockage blockage|nmod|END_ENTITY	The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic_cancer cells in vitro .
22157761	0	IL-6	99,103	STAT3	66,71	IL-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_3|appos|START_ENTITY signal_transducer_and_activator_of_transcription_3|appos|END_ENTITY	Inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- attenuates interleukin-6 -LRB- IL-6 -RRB- - induced collagen synthesis and resultant hypertrophy in rat heart .
22194466	0	IL-6	90,94	STAT3	95,100	IL-6	STAT3	3569	6774	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Metastatic cells can escape the proapoptotic effects of TNF-a through increased autocrine IL-6 / STAT3 signaling .
22273698	0	IL-6	0,4	STAT3	16,21	IL-6	STAT3	3569	6774	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|kinase kinase|compound|END_ENTITY	IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic_cancer cell lines .
22394507	0	IL-6	20,24	STAT3	25,30	IL-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Quercetin abrogates IL-6 / STAT3 signaling and inhibits glioblastoma cell line growth and migration .
22469658	0	IL-6	8,12	STAT3	50,55	IL-6	STAT3	503562(Tax:31033)	101070968	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|signaling signaling|compound|END_ENTITY	Teleost IL-6 promotes antibody production through STAT3 signaling via IL-6R and gp130 .
22581330	0	IL-6	71,75	STAT3	0,5	IL-6	STAT3	3569	6774	Gene	Gene	STAT3|compound|START_ENTITY blockage|nmod|STAT3 correlated|xcomp|blockage correlated|nsubj|mutations mutations|compound|END_ENTITY	STAT3 mutations correlated with hyper-IgE_syndrome lead to blockage of IL-6 / STAT3 signalling pathway .
22585093	0	IL-6	72,76	STAT3	77,82	IL-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	Proline protects liver from D-galactosamine hepatitis by activating the IL-6 / STAT3 survival signaling pathway .
22743617	0	IL-6	20,24	STAT3	0,5	IL-6	STAT3	3569	6774	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma .
22937006	0	IL-6	62,66	STAT3	116,121	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	promotes|dobj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1b production in macrophages by targeting STAT3 .
23238769	0	IL-6	74,78	STAT3	79,84	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY signals|compound|END_ENTITY	A20 promotes liver_regeneration by decreasing SOCS3 expression to enhance IL-6 / STAT3 proliferative signals .
23408169	0	IL-6	159,163	STAT3	164,169	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Proximal tubule-specific overexpression of netrin-1 suppresses acute_kidney_injury-induced interstitial_fibrosis and glomerulosclerosis through suppression of IL-6 / STAT3 signaling .
23630344	0	IL-6	0,4	STAT3	98,103	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|G-CSF G-CSF|xcomp|induce induce|advcl|enhancing enhancing|dobj|activation activation|compound|END_ENTITY	IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation .
24004609	0	IL-6	16,20	STAT3	56,61	IL-6	STAT3	3569	6774	Gene	Gene	secretion|compound|START_ENTITY secretion|appos|regulation regulation|nmod|signaling signaling|compound|END_ENTITY	Arsenite evokes IL-6 secretion , autocrine regulation of STAT3 signaling , and miR-21 expression , processes involved in the EMT and malignant transformation of human bronchial epithelial cells .
24082147	0	IL-6	32,36	STAT3	0,5	IL-6	STAT3	3569	6774	Gene	Gene	response|nmod|START_ENTITY activation|nmod|response activation|nummod|END_ENTITY	STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor .
24082147	0	IL-6	68,72	STAT3	0,5	IL-6	STAT3	3569	6774	Gene	Gene	receptor|compound|START_ENTITY the|nmod|receptor prolonged|nmod|the prolonged|nsubj|activation activation|nummod|END_ENTITY	STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor .
24101153	0	IL-6	106,110	STAT3	111,116	IL-6	STAT3	3569	6774	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Generation of prostate_tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6 / STAT3 signaling .
24244348	0	IL-6	14,18	STAT3	27,32	IL-6	STAT3	3569	6774	Gene	Gene	ensures|nsubj|START_ENTITY ensures|dobj|activation activation|compound|END_ENTITY	NF-kB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma .
24473196	0	IL-6	74,78	STAT3	0,5	IL-6	STAT3	3569	6774	Gene	Gene	inhibit|nmod|START_ENTITY forms|xcomp|inhibit forms|nsubj|induction induction|nummod|END_ENTITY	STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-kB to IL-6 signaling axis and STAT3-driven cancer phenotypes .
24682171	0	IL-6	47,51	STAT3	52,57	IL-6	STAT3	3569	6774	Gene	Gene	blocks|dobj|START_ENTITY binder|acl:relcl|blocks binder|parataxis|suppresses suppresses|nsubj|signaling signaling|compound|END_ENTITY	A high-affinity protein binder that blocks the IL-6 / STAT3 signaling pathway effectively suppresses non-small_cell_lung_cancer .
24863036	0	IL-6	22,26	STAT3	27,32	IL-6	STAT3	3569	6774	Gene	Gene	Angoline|dep|START_ENTITY Angoline|parataxis|signaling signaling|nsubj|END_ENTITY	Angoline : a selective IL-6 / STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum .
25136113	0	IL-6	0,4	STAT3	5,10	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	IL-6 / STAT3 promotes regeneration of airway ciliated cells from basal stem cells .
25340554	0	IL-6	93,97	STAT3	73,78	IL-6	STAT3	3569	6774	Gene	Gene	Cytokines|compound|START_ENTITY Activation|nmod|Cytokines Activation|compound|END_ENTITY	The Inhibition of N-Glycosylation of Glycoprotein_130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
25481644	0	IL-6	81,85	STAT3	51,56	IL-6	STAT3	3569	6774	Gene	Gene	transactivation|compound|START_ENTITY contributes|nmod|transactivation contributes|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Sphingosine_kinase_1 contributes to leptin-induced STAT3 phosphorylation through IL-6 / gp130 transactivation in oestrogen receptor-negative breast_cancer .
25544427	0	IL-6	14,18	STAT3	19,24	IL-6	STAT3	3569	6774	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|axis axis|dep|END_ENTITY	Inhibition of IL-6 / STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian_cancer cells .
25604648	0	IL-6	0,4	STAT3	5,10	IL-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|appos|contributes contributes|nsubj|signaling signaling|compound|END_ENTITY	IL-6 / STAT3 signaling pathway contributes to chondrogenic differentiation of human mesenchymal stem cells .
25713055	0	IL-6	91,95	STAT3	96,101	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY suppression|parataxis|signaling signaling|nsubj|END_ENTITY	15-Lipoxygenase-1 suppression of colitis-associated colon_cancer through inhibition of the IL-6 / STAT3 signaling pathway .
25750173	0	IL-6	30,34	STAT3	35,40	IL-6	STAT3	3569	6774	Gene	Gene	expressed|nmod|START_ENTITY Aberrantly|acl|expressed Aberrantly|parataxis|promotes promotes|nsubj|transactivation transactivation|compound|END_ENTITY	Aberrantly expressed Fra-1 by IL-6 / STAT3 transactivation promotes colorectal_cancer_aggressiveness through epithelial-mesenchymal transition .
25826381	0	IL-6	105,109	STAT3	85,90	IL-6	STAT3	3569	6774	Gene	Gene	Cytokines|compound|START_ENTITY Inhibition|nmod|Cytokines Inhibition|nmod|N-Glycosylation N-Glycosylation|nmod|Activation Activation|compound|END_ENTITY	Correction : The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
26019757	0	IL-6	26,30	STAT3	31,36	IL-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|dep|Signaling Signaling|compound|END_ENTITY	Epigenetic Alterations of IL-6 / STAT3 Signaling by Placental Stem Cells Promote Hepatic Regeneration in a Rat Model with CCl4-induced Liver_Injury .
26019757	0	IL-6	26,30	STAT3	31,36	IL-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|dep|Signaling Signaling|compound|END_ENTITY	Epigenetic Alterations of IL-6 / STAT3 Signaling by Placental Stem Cells Promote Hepatic Regeneration in a Rat Model with CCl4-induced Liver_Injury .
26062544	0	IL-6	38,42	STAT3	43,48	IL-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|pathway pathway|nummod|END_ENTITY	Hepato-protective effect of rutin via IL-6 / STAT3 pathway in CCl4-induced hepatotoxicity in rats .
26101800	0	IL-6	4,8	STAT3	9,14	IL-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|pathway pathway|nummod|END_ENTITY	The IL-6 / STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes .
26166037	0	IL-6	59,63	STAT3	49,54	IL-6	STAT3	3569	6774	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6 / JAK1/STAT3 signal pathway in Gefitinib-resistant lung_cancer cells .
26452542	0	IL-6	39,43	STAT3	44,49	IL-6	STAT3	3569	6774	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Long noncoding RNA lncTCF7 , induced by IL-6 / STAT3 transactivation , promotes hepatocellular_carcinoma aggressiveness through epithelial-mesenchymal transition .
26484199	0	IL-6	89,93	STAT3	68,73	IL-6	STAT3	3569	6774	Gene	Gene	axis|compound|START_ENTITY activation|nmod|axis activation|nummod|END_ENTITY	Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6 / IL-6Ra axis .
26587789	0	IL-6	81,85	STAT3	86,91	IL-6	STAT3	3569	6774	Gene	Gene	Degradation|nmod|START_ENTITY Contributes|nmod|Degradation Contributes|dep|Pathway Pathway|compound|END_ENTITY	Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6 / STAT3 Signalling Pathway in Human Intervertebral Disc Degeneration .
26711554	0	IL-6	71,75	STAT3	76,81	IL-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	Suppression|nmod|START_ENTITY Suppression|dep|pathway pathway|nummod|END_ENTITY	Suppression of colitis-associated_carcinogenesis through modulation of IL-6 / STAT3 pathway by Balsalazide and VSL # 3 .
26722442	0	IL-6	0,4	STAT3	5,10	IL-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|appos|activated activated|nsubjpass|signaling signaling|compound|END_ENTITY	IL-6 / STAT3 signaling pathway is activated in plasma cell mastitis .
26738736	0	IL-6	0,4	STAT3	5,10	IL-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|appos|Plays Plays|nsubj|END_ENTITY	IL-6 / STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells .
26812074	0	IL-6	63,67	STAT3	68,73	IL-6	STAT3	3569	6774	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Long non-coding RNA DILC regulates liver_cancer stem cells via IL-6 / STAT3 axis .
26847351	0	IL-6	48,52	STAT3	53,58	IL-6	STAT3	3569	6774	Gene	Gene	mediated|nmod|START_ENTITY repression|acl|mediated repression|parataxis|promotes promotes|nsubj|signaling signaling|compound|END_ENTITY	Transcriptional repression of SOCS3 mediated by IL-6 / STAT3 signaling via DNMT1 promotes pancreatic_cancer growth and metastasis .
26921327	0	IL-6	54,58	STAT3	59,64	IL-6	STAT3	3569	6774	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|dep|mediated	Resistance to anti-VEGF therapy mediated by autocrine IL-6 / STAT3 signaling and overcome by IL-6 blockade .
26921327	0	IL-6	91,95	STAT3	59,64	IL-6	STAT3	3569	6774	Gene	Gene	blockade|compound|START_ENTITY signaling|nmod|blockade END_ENTITY|acl|signaling	Resistance to anti-VEGF therapy mediated by autocrine IL-6 / STAT3 signaling and overcome by IL-6 blockade .
27006530	0	IL-6	0,4	STAT3	24,29	IL-6	STAT3	3569	6774	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin .
11564778	0	IL-6	84,88	STAT5	0,5	IL-6	STAT5	16193(Tax:10090)	20850(Tax:10090)	Gene	Gene	production|compound|START_ENTITY activation|nmod|production induces|nmod|activation induces|nsubj|END_ENTITY	STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65 .
22854263	0	IL-6	0,4	STAT5	15,20	IL-6	STAT5	16193(Tax:10090)	20850(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	IL-6 activates STAT5 in T cells .
21619877	0	IL-6	18,22	STAT_3	45,51	IL-6	STAT 3	3569	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The STAT3 beacon : IL-6 recurrently activates STAT_3 from endosomal structures .
9126968	0	IL-6	13,17	Shc	0,3	IL-6	Shc	3569	6464	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase .
21422245	0	IL-6	0,4	Src_homology_domain_2-containing_tyrosine_phosphatase-1	56,111	IL-6	Src homology domain 2-containing tyrosine phosphatase-1	16193(Tax:10090)	15170(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	IL-6 production is positively regulated by two distinct Src_homology_domain_2-containing_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- - dependent CCAAT/enhancer-binding protein b and NF-kB pathways and an SHP-1-independent NF-kB pathway in lipopolysaccharide-stimulated bone marrow-derived macrophages .
12075433	0	IL-6	105,109	Stat3	67,72	IL-6	Stat3	3569	6774	Gene	Gene	-3|nmod|START_ENTITY -3|nmod|Activation Activation|nmod|END_ENTITY	Phosphatidylinositol -LRB- PI -RRB- -3 Kinase Contributes to the Activation of Stat3 in M1 Leukemia Cells Induced by IL-6 .
14523032	0	IL-6	25,29	Stat3	30,35	IL-6	Stat3	3569	6774	Gene	Gene	Hepatoprotection|nmod|START_ENTITY /|nsubj|Hepatoprotection /|dobj|END_ENTITY	Hepatoprotection via the IL-6 / Stat3 pathway .
16732314	0	IL-6	19,23	Stat3	28,33	IL-6	Stat3	3569	6774	Gene	Gene	START_ENTITY|nmod|HS4 HS4|compound|END_ENTITY	BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription .
18270592	0	IL-6	50,54	Stat3	65,70	IL-6	Stat3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	hypovolemic_circulatory_collapse|nmod|START_ENTITY END_ENTITY|amod|hypovolemic_circulatory_collapse	Prevention of hypovolemic_circulatory_collapse by IL-6 activated Stat3 .
20482858	0	IL-6	11,15	Stat3	43,48	IL-6	Stat3	3569	6774	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic_cancer cells in vitro .
22349830	0	IL-6	35,39	Stat3	40,45	IL-6	Stat3	3569	6774	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|parataxis|signaling signaling|nsubj|survival survival|amod|END_ENTITY	Role of MMP-2 in the regulation of IL-6 / Stat3 survival signaling via interaction with a5b1 integrin in glioma .
22838736	0	IL-6	28,32	Stat3	41,46	IL-6	Stat3	3569	6774	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activity activity|amod|END_ENTITY	Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma .
24803294	0	IL-6	27,31	Stat3	32,37	IL-6	Stat3	3569	6774	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Andrographolide suppresses IL-6 / Stat3 signaling in peripheral blood mononuclear cells from patients with chronic rhinosinusitis with nasal_polyps .
25997003	0	IL-6	81,85	Stat3	86,91	IL-6	Stat3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Anti-Fibrotic Effects of Class I HDAC Inhibitor , Mocetinostat Is Associated with IL-6 / Stat3 Signaling in Ischemic_Heart_Failure .
26327817	0	IL-6	133,137	Stat3	138,143	IL-6	Stat3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Initiation|nmod|Activation Initiation|parataxis|Pathway Pathway|compound|END_ENTITY	Defective Initiation of Liver_Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6 / Stat3 Pathway .
8637711	0	IL-6	31,35	Stat3	82,87	IL-6	Stat3	3569	6774	Gene	Gene	element|compound|START_ENTITY complexes|nmod|element contain|nsubj|complexes contain|dobj|END_ENTITY	IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein -LRB- s -RRB- .
19494314	0	IL-6	51,55	Steel_factor	0,12	IL-6	Steel factor	3569	4254	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Steel_factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta .
14597766	0	IL-6	54,58	Stem_cell_factor	0,16	IL-6	Stem cell factor	16193(Tax:10090)	17311(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY restores|nmod|mice restores|nsubj|END_ENTITY	Stem_cell_factor restores hepatocyte proliferation in IL-6 knockout mice following 70 % hepatectomy .
24453276	0	IL-6	50,54	Stem_cell_factor	0,16	IL-6	Stem cell factor	16193(Tax:10090)	17311(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Stem_cell_factor induces AP-1-dependent mast cell IL-6 production via MAPK kinase 3 activity .
16287972	0	IL-6	68,72	Suppressor_of_cytokine_signaling-1	0,34	IL-6	Suppressor of cytokine signaling-1	3569	8651	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Suppressor_of_cytokine_signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT .
20876575	0	IL-6	56,60	Suppressor_of_cytokine_signaling_3	0,34	IL-6	Suppressor of cytokine signaling 3	3569	9021	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Suppressor_of_cytokine_signaling_3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein -LCB- beta -RCB- activity .
24819026	0	IL-6	60,64	TGF-b1	73,79	IL-6	TGF-b1	3569	7040	Gene	Gene	IFN-y|compound|START_ENTITY IFN-y|dep|END_ENTITY	Prognostic importance of single-nucleotide polymorphisms in IL-6 , IL-10 , TGF-b1 , IFN-y , and TNF-a genes in chronic_phase_chronic_myeloid_leukemia .
12406387	0	IL-6	72,76	TGF-beta	31,39	IL-6	TGF-beta	3569	7040	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Up-regulation of production of TGF-beta and IL-4 and down-regulation of IL-6 by apoptotic human bronchial epithelial cells .
15485627	0	IL-6	71,75	TGF-beta	0,8	IL-6	TGF-beta	16193(Tax:10090)	21803(Tax:10090)	Gene	Gene	trans-signaling|compound|START_ENTITY inhibition|nmod|trans-signaling suppresses|nmod|inhibition suppresses|nsubj|END_ENTITY	TGF-beta suppresses tumor progression in colon_cancer by inhibition of IL-6 trans-signaling .
15848524	0	IL-6	57,61	TGF-beta	36,44	IL-6	TGF-beta	3569	7040	Gene	Gene	MCP-1|compound|START_ENTITY TNF-alpha|dep|MCP-1 TNF-alpha|compound|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
18600325	0	IL-6	44,48	TGF-beta	34,42	IL-6	TGF-beta	3569	7040	Gene	Gene	IL-17|dep|START_ENTITY IL-17|dep|END_ENTITY	Profile of Th17 cytokines -LRB- IL-17 , TGF-beta , IL-6 -RRB- and Th1 cytokine -LRB- IFN-gamma -RRB- in patients with immune_thrombocytopenic_purpura .
19501566	0	IL-6	74,78	TGF-beta	0,8	IL-6	TGF-beta	3569	7040	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23 .
20713723	0	IL-6	9,13	TGF-beta	0,8	IL-6	TGF-beta	3569	21803(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung_cancer .
7751003	0	IL-6	49,53	TGF-beta	0,8	IL-6	TGF-beta	3569	7040	Gene	Gene	levels|amod|START_ENTITY enhance|dobj|levels act|xcomp|enhance act|nsubj|END_ENTITY	TGF-beta and IL-1_beta act in synergy to enhance IL-6 and IL-8 mRNA levels and IL-6 production by human retinal_pigment_epithelial cells .
7858060	0	IL-6	153,157	TGF-beta	14,22	IL-6	TGF-beta	3569	7040	Gene	Gene	stimulation|nmod|START_ENTITY regulator|nmod|stimulation TGF-beta|nmod|regulator evidence|nmod|TGF-beta Expression|dep|evidence Expression|nmod|isoforms isoforms|amod|END_ENTITY	Expression of TGF-beta isoforms by Thy-1 + and Thy-1 - pulmonary fibroblast subsets : evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6 .
7858060	0	IL-6	153,157	TGF-beta	96,104	IL-6	TGF-beta	3569	7040	Gene	Gene	stimulation|nmod|START_ENTITY regulator|nmod|stimulation END_ENTITY|nmod|regulator	Expression of TGF-beta isoforms by Thy-1 + and Thy-1 - pulmonary fibroblast subsets : evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6 .
10925306	0	IL-6	174,178	TGF-beta_1	47,57	IL-6	TGF-beta 1	3569	7040	Gene	Gene	expression|compound|START_ENTITY involvement|nmod|expression Requirement|dep|involvement Requirement|nmod|generation generation|nmod|transduction transduction|compound|END_ENTITY	Requirement of hydrogen_peroxide generation in TGF-beta_1 signal transduction in human lung fibroblast cells : involvement of hydrogen_peroxide and Ca2 + in TGF-beta_1-induced IL-6 expression .
14734728	0	IL-6	43,47	TGF-beta_1	74,84	IL-6	TGF-beta 1	3569	7040	Gene	Gene	secretion|nmod|START_ENTITY antagonizes|nsubj|secretion antagonizes|dobj|END_ENTITY	Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta_1 and restores the lymphokine-activated killing activity .
21591983	0	IL-6	47,51	TGF-beta_1	28,38	IL-6	TGF-beta 1	3569	7040	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
8742067	0	IL-6	86,90	TGF-beta_1	0,10	IL-6	TGF-beta 1	3569	7040	Gene	Gene	expression|nmod|START_ENTITY modulate|dobj|expression modulate|nsubj|differentially differentially|compound|END_ENTITY	TGF-beta_1 , IL-10 and IL-4 differentially modulate the cytokine-induced expression of IL-6 and IL-8 in human endothelial cells .
8552986	0	IL-6	118,122	TGF_beta	137,145	IL-6	TGF beta	3569	7040	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
20607798	0	IL-6	14,18	TGFb1	0,5	IL-6	TGFb1	3569	7040	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TGFb1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells : the role of Smad2/3 .
26063187	0	IL-6	19,23	THP-1	85,90	IL-6	THP-1	3569	2736	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Macrophages Macrophages|compound|END_ENTITY	Ox-LDL Upregulates IL-6 Expression by Enhancing NF-kB in an IGF2-Dependent Manner in THP-1 Macrophages .
24416448	0	IL-6	29,33	TL1A	0,4	IL-6	TL1A	3569	9966	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TL1A induces TCR independent IL-6 and TNF-a production and growth of PLZF leukocytes .
27081759	0	IL-6	15,19	TL1A	0,4	IL-6	TL1A	3569	9966	Gene	Gene	production|compound|START_ENTITY increased|dobj|production increased|nsubj|END_ENTITY	TL1A increased IL-6 production on fibroblast-like synoviocytes by preferentially activating TNF receptor 2 in rheumatoid_arthritis .
18343502	0	IL-6	36,40	TLR4	99,103	IL-6	TLR4	3569	7099	Gene	Gene	production|nsubj|START_ENTITY production|nmod|cells cells|nmod|expression expression|compound|END_ENTITY	Rapamycin suppresses TLR4-triggered IL-6 and PGE -LRB- 2 -RRB- production of colon_cancer cells by inhibiting TLR4 expression and NF-kappaB activation .
22030478	0	IL-6	72,76	TLR4	16,20	IL-6	TLR4	3569	7099	Gene	Gene	transcription|compound|START_ENTITY coordinates|nmod|transcription coordinates|nsubj|Coactivation Coactivation|nmod|END_ENTITY	Coactivation of TLR4 and TLR2/6 coordinates an additive augmentation on IL-6 gene transcription via p38MAPK pathway in U937 mononuclear cells .
22934260	0	IL-6	104,108	TLR4	0,4	IL-6	TLR4	3569	7099	Gene	Gene	regulate|dobj|START_ENTITY cells|acl:relcl|regulate induces|nmod|cells induces|nsubj|signaling signaling|compound|END_ENTITY	TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA_let-7b .
27091427	0	IL-6	27,31	TLR4	0,4	IL-6	TLR4	16193(Tax:10090)	21898(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	TLR4 induces CREB-mediated IL-6 production via upregulation of F-spondin to promote vascular smooth muscle cell migration .
10049519	0	IL-6	86,90	TNF	74,77	IL-6	TNF	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	chemoattractant|amod|START_ENTITY induces|dobj|chemoattractant induces|nsubj|END_ENTITY	Generation of inflammatory cytokines in zymosan-induced pleurisy in rats : TNF induces IL-6 and cytokine-induced neutrophil chemoattractant -LRB- CINC -RRB- in vivo .
10722865	0	IL-6	84,88	TNF	102,105	IL-6	TNF	3569	7124	Gene	Gene	respond|nmod|START_ENTITY makes|ccomp|respond makes|parataxis|inhibits inhibits|dobj|production production|compound|END_ENTITY	Soluble interleukin-6_receptor -LRB- sIL-6R -RRB- makes IL-6R negative T cell line respond to IL-6 ; it inhibits TNF production .
10930297	0	IL-6	12,16	TNF	59,62	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|production production|compound|END_ENTITY	Lps induces IL-6 in the brain and in serum largely through TNF production .
17070836	0	IL-6	84,88	TNF	120,123	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY differences|appos|expression differences|dep|role role|nmod|receptor receptor|compound|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
17070836	0	IL-6	84,88	TNF	79,82	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY differences|appos|expression differences|appos|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
1878339	0	IL-6	62,66	TNF	0,3	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY vitro|nmod|synthesis inhibits|advcl|vitro inhibits|nsubj|END_ENTITY	TNF inhibits malaria hepatic stages in vitro via synthesis of IL-6 .
2001421	0	IL-6	63,67	TNF	23,26	IL-6	TNF	3569	7124	Gene	Gene	interleukin|amod|START_ENTITY inhibits|dobj|interleukin inhibits|nsubj|Tumor_necrosis_factor Tumor_necrosis_factor|appos|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- inhibits interleukin -LRB- IL -RRB- -1 and/or IL-6 stimulated synthesis of C-reactive_protein -LRB- CRP -RRB- and serum_amyloid_A -LRB- SAA -RRB- in primary cultures of human hepatocytes .
21744329	0	IL-6	67,71	TNF	80,83	IL-6	TNF	3569	7124	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
8164194	0	IL-6	14,18	TNF	9,12	IL-6	TNF	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	production|amod|START_ENTITY milk|nsubj|production milk|nmod|END_ENTITY	In vitro TNF , IL-6 and IL-2 production by rat milk cells following Trichinella_spiralis_infection .
8244453	0	IL-6	68,72	TNF	52,55	IL-6	TNF	3569	7124	Gene	Gene	not|nmod|START_ENTITY inhibition|dep|not inhibition|nmod|production production|nmod|END_ENTITY	Chloroquine-induced inhibition of the production of TNF , but not of IL-6 , is affected by disruption of iron metabolism .
8589268	0	IL-6	179,183	TNF	120,123	IL-6	TNF	3569	7124	Gene	Gene	production|compound|START_ENTITY down-regulation|nmod|production regulate|nmod|down-regulation regulate|dobj|production production|dep|up-regulation up-regulation|nmod|END_ENTITY	Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes : up-regulation of TNF , IFN-gamma and IL-2 , in contrast to down-regulation of IL-6 production .
8955207	0	IL-6	77,81	TNF	0,3	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	increases|nmod|START_ENTITY role|nmod|increases plays|dobj|role plays|nsubj|p55 p55|compound|END_ENTITY	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF .
8955207	0	IL-6	77,81	TNF	144,147	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	increases|nmod|START_ENTITY role|nmod|increases plays|dobj|role plays|nmod|injection injection|nmod|END_ENTITY	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF .
9195128	0	IL-6	24,28	TNF	67,70	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of IL-6 on systemic and central production of TNF : a study with IL-6-deficient mice .
9216689	0	IL-6	26,30	TNF	19,22	IL-6	TNF	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effect of blocking TNF on IL-6 levels and metastasis in a B16-BL6 melanoma/mouse model .
9228922	0	IL-6	0,4	TNF	87,90	IL-6	TNF	24498(Tax:10116)	103694380	Gene	Gene	release|compound|START_ENTITY release|parataxis|control control|nmod|END_ENTITY	IL-6 release after intestinal_ischemia / reperfusion in rats is under partial control of TNF .
9728802	0	IL-6	4,8	TNF	132,135	IL-6	TNF	3569	7124	Gene	Gene	gene|compound|START_ENTITY expression|nsubj|gene expression|nmod|END_ENTITY	The IL-6 gene expression by leukemic cells from acute_lymphoblastic_leukemia common and T type and modulation of IL-6 production by TNF .
20856228	0	IL-6	68,72	TNF-a	23,28	IL-6	TNF-a	3569	7124	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|Blockade Blockade|nmod|signaling signaling|compound|END_ENTITY	RETRACTED : Blockade of TNF-a signaling suppresses the AREG-mediated IL-6 and IL-8 cytokines secretion induced by anti-Ro/SSA autoantibodies .
21251905	0	IL-6	43,47	TNF-a	63,68	IL-6	TNF-a	3569	7124	Gene	Gene	cell|amod|START_ENTITY interactions|nmod|cell END_ENTITY|nsubj|interactions	Consistent interactions between tumor cell IL-6 and macrophage TNF-a enhance the growth of human prostate_cancer cells in the bone of nude mouse .
21913564	0	IL-6	66,70	TNF-a	72,77	IL-6	TNF-a	3569	7124	Gene	Gene	Studies|amod|START_ENTITY Studies|acl|END_ENTITY	-LSB- Studies on the level of proinflammatory cytokines IIL-1a , IL-1b , IL-6 , TNF-a in pregnant women with acute pyelonephritis -RSB- .
21930349	0	IL-6	67,71	TNF-a	73,78	IL-6	TNF-a	3569	7124	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of proinflammatory cytokines IL-1b , IL-6 , TNF-a and involvement of COX-2 , quantitatively confirmed by Western blot analysis , in Wernicke 's _ encephalopathy .
22158445	0	IL-6	8,12	TNF-a	73,78	IL-6	TNF-a	3569	7124	Gene	Gene	polymorphism|compound|START_ENTITY predicts|nsubj|polymorphism predicts|nmod|blockers blockers|amod|END_ENTITY	-174 G/C _ IL-6 gene promoter polymorphism predicts therapeutic response to TNF-a blockers .
22194466	0	IL-6	90,94	TNF-a	56,61	IL-6	TNF-a	3569	7124	Gene	Gene	signaling|compound|START_ENTITY escape|nmod|signaling escape|dobj|effects effects|nmod|END_ENTITY	Metastatic cells can escape the proapoptotic effects of TNF-a through increased autocrine IL-6 / STAT3 signaling .
22405769	0	IL-6	146,150	TNF-a	93,98	IL-6	TNF-a	3569	7124	Gene	Gene	action|nmod|START_ENTITY elicit|nmod|action elicit|dobj|expression expression|nmod|END_ENTITY	Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-a on macrophages through the autocrine action of IL-6 .
22760836	0	IL-6	26,30	TNF-a	65,70	IL-6	TNF-a	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	A study of interleukin_6 -LRB- IL-6 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF-a -RRB- serum levels in rats subjected to fecal_peritonitis and treated with intraperitoneal ropivacaine .
23886206	0	IL-6	110,114	TNF-a	83,88	IL-6	TNF-a	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|compound|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
25066751	0	IL-6	90,94	TNF-a	83,88	IL-6	TNF-a	3569	7124	Gene	Gene	IL-10|appos|START_ENTITY IL-10|compound|END_ENTITY	Sequential determination of serum viral titers , virus-specific IgG antibodies , and TNF-a , IL-6 , IL-10 , and IFN-y levels in patients with Crimean-Congo_hemorrhagic_fever .
25844135	0	IL-6	47,51	TNF-a	40,45	IL-6	TNF-a	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The time-course and RNA interference of TNF-a , IL-6 , and IL-1b expression on neuropathic_pain induced by L5 spinal nerve transection in rats .
26045939	0	IL-6	60,64	TNF-a	53,58	IL-6	TNF-a	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Corrigendum : The time-course and RNA interference of TNF-a , IL-6 , and IL-1b expression on neuropathic_pain induced by L5 spinal nerve transection in rats -LRB- Korean J Anesthesiol 2015 April 68 -LRB- 2 -RRB- : 159-169 -RRB- .
10462929	0	IL-6	47,51	TNF-alpha	53,62	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-1_beta|dep|START_ENTITY IL-1_beta|dep|END_ENTITY	Study on proinflammatory cytokines -LRB- IL-1_beta , IL-6 , TNF-alpha -RRB- and IL-2 in patients with acute hepatitis_B .
10528667	0	IL-6	57,61	TNF-alpha	63,72	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-1beta|appos|START_ENTITY IL-1beta|appos|END_ENTITY	Whole blood production of monocytic cytokines -LRB- IL-1beta , IL-6 , TNF-alpha , sIL-6R , IL-1Ra -RRB- in haemodialysed patients .
10552211	0	IL-6	47,51	TNF-alpha	111,120	IL-6	TNF-alpha	3569	7124	Gene	Gene	amounts|nmod|START_ENTITY secrete|dobj|amounts secrete|nmod|END_ENTITY	Psoriatic fibroblasts secrete lower amounts of IL-6 than healthy fibroblasts before and after stimulation with TNF-alpha .
10601562	0	IL-6	56,60	TNF-alpha	114,123	IL-6	TNF-alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|compound|START_ENTITY upregulate|dobj|production upregulate|nmod|cells cells|nmod|independent independent|nmod|END_ENTITY	Elevated GM-CSF levels in tumor bearing mice upregulate IL-6 production by B cells via a mechanism independent of TNF-alpha .
10620700	0	IL-6	52,56	TNF-alpha	86,95	IL-6	TNF-alpha	3569	7124	Gene	Gene	production|amod|START_ENTITY production|nmod|fibroblasts fibroblasts|amod|END_ENTITY	The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha - or IL-1beta-stimulated rheumatoid synovial fibroblasts .
10623436	0	IL-6	70,74	TNF-alpha	59,68	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-1beta|dep|START_ENTITY IL-1beta|dep|END_ENTITY	Direct influences of pro-inflammatory cytokines -LRB- IL-1beta , TNF-alpha , IL-6 -RRB- on the proliferation and cell-surface_antigen expression of cancer cells .
10697395	0	IL-6	64,68	TNF-alpha	34,43	IL-6	TNF-alpha	3569	7124	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	-LSB- Levels of tumor_necrosis_factor -LRB- TNF-alpha -RRB- and interleukin_6 -LRB- IL-6 -RRB- in serum of patients with acute myocardial_infarction -RSB- .
10951379	0	IL-6	73,77	TNF-alpha	42,51	IL-6	TNF-alpha	3569	7124	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Combined effect of titanium particles and TNF-alpha on the production of IL-6 by osteoblast-like cells .
10978634	0	IL-6	62,66	TNF-alpha	68,77	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-1beta|dep|START_ENTITY IL-1beta|dep|END_ENTITY	Quantitative analysis of proinflammatory cytokines -LRB- IL-1beta , IL-6 , TNF-alpha -RRB- in human skin_wounds .
11266093	0	IL-6	11,15	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	serum|nsubj|START_ENTITY serum|advmod|END_ENTITY	TNF-alpha , IL-6 and their soluble receptor serum levels and secretion by neutrophils in cancer patients .
11370171	0	IL-6	79,83	TNF-alpha	19,28	IL-6	TNF-alpha	3569	7124	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|secretion secretion|nmod|END_ENTITY	Local secretion of TNF-alpha from the liver does not correlate with endotoxin , IL-6 , or organ function in the early phase after orthotopic liver transplantation .
11544427	0	IL-6	11,15	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|compound|END_ENTITY	TNF-alpha , IL-6 , IFN-gamma , and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R : effects on renal allograft outcome .
11743653	0	IL-6	46,50	TNF-alpha	29,38	IL-6	TNF-alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	roles|appos|START_ENTITY roles|appos|END_ENTITY	Discrete roles of cytokines , TNF-alpha , IL-1 , IL-6 in tumor promotion and cell transformation .
11819289	0	IL-6	33,37	TNF-alpha	23,32	IL-6	TNF-alpha	3569	7124	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	In vitro production of TNF-alpha , IL-6 and sIL-2R in Chinese patients with ulcerative_colitis .
12370360	0	IL-6	28,32	TNF-alpha	85,94	IL-6	TNF-alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nmod|END_ENTITY	IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha .
12445803	0	IL-6	104,108	TNF-alpha	78,87	IL-6	TNF-alpha	3569	7124	Gene	Gene	interleukin-6|dep|START_ENTITY factor-alpha|amod|interleukin-6 factor-alpha|appos|END_ENTITY	Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- interleukin-6 -LRB- IL-6 -RRB- and soluble interleukin-6_receptor -LRB- sIL-6R gp80 -RRB- in multiple_sclerosis patients .
12477628	0	IL-6	85,89	TNF-alpha	91,100	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-1beta|dep|START_ENTITY IL-1beta|dep|END_ENTITY	Time-dependent immunohistochemical detection of proinflammatory cytokines -LRB- IL-1beta , IL-6 , TNF-alpha -RRB- in human skin_wounds .
12817006	0	IL-6	157,161	TNF-alpha	0,9	IL-6	TNF-alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex phosphatase|nmod|subunit induces|xcomp|phosphatase induces|nsubj|END_ENTITY	TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex .
12954239	0	IL-6	43,47	TNF-alpha	49,58	IL-6	TNF-alpha	517016(Tax:9913)	280943(Tax:9913)	Gene	Gene	IL-1_alpha|dep|START_ENTITY IL-1_alpha|dep|IFN-gamma IFN-gamma|compound|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
15298427	0	IL-6	113,117	TNF-alpha	102,111	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-10|amod|START_ENTITY reaction|amod|IL-10 reaction|dep|effects effects|nmod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
15383953	0	IL-6	62,66	TNF-alpha	41,50	IL-6	TNF-alpha	3569	7124	Gene	Gene	IFN-gamma|compound|START_ENTITY END_ENTITY|dep|IFN-gamma	-LSB- Evaluation of proinflammatory cytokine -LRB- TNF-alpha , IL-1beta , IL-6 , IFN-gamma -RRB- concentrations in serum and cerebrospinal fluid of patients with neuroborreliosis -RSB- .
15622443	0	IL-6	29,33	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
15663746	0	IL-6	23,27	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	TNF-beta|parataxis|START_ENTITY END_ENTITY|dep|TNF-beta	TNF-alpha - , TNF-beta - , IL-6 - , and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary_disease .
15665514	0	IL-6	152,156	TNF-alpha	69,78	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha - and LPS-induced NF-kappaB-dependent transcription and TNF-alpha-induced IL-6 secretion in ventricular myocytes .
15848524	0	IL-6	57,61	TNF-alpha	46,55	IL-6	TNF-alpha	3569	7124	Gene	Gene	MCP-1|compound|START_ENTITY END_ENTITY|dep|MCP-1	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
16258194	0	IL-6	38,42	TNF-alpha	16,25	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-17|appos|START_ENTITY IL-17|compound|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
1636726	0	IL-6	0,4	TNF-alpha	14,23	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|increase increase|amod|END_ENTITY	IL-6 enhances TNF-alpha - and IL-1-induced increase of Mn_superoxide dismutase mRNA and O2 tolerance .
16734992	0	IL-6	48,52	TNF-alpha	37,46	IL-6	TNF-alpha	3569	7124	Gene	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	The effect of periodontal therapy on TNF-alpha , IL-6 and metabolic control in type 2 diabetics .
16857895	0	IL-6	86,90	TNF-alpha	65,74	IL-6	TNF-alpha	3569	7124	Gene	Gene	secretion|compound|START_ENTITY prevents|nmod|secretion prevents|dobj|effects effects|nmod|END_ENTITY	High dexamethasone concentration prevents stimulatory effects of TNF-alpha and LPS on IL-6 secretion from the precursors of human muscle regeneration .
16864705	0	IL-6	73,77	TNF-alpha	78,87	IL-6	TNF-alpha	3569	7124	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Innate immunity of the human newborn is polarized toward a high ratio of IL-6 / TNF-alpha production in vitro and in vivo .
17483704	0	IL-6	21,25	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|compound|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
17725274	0	IL-6	136,140	TNF-alpha	109,118	IL-6	TNF-alpha	3569	7124	Gene	Gene	interleukin_6|appos|START_ENTITY vascular_endothelial_growth_factor|appos|interleukin_6 vascular_endothelial_growth_factor|appos|tumor_necrosis_factor tumor_necrosis_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
17901573	0	IL-6	129,133	TNF-alpha	107,116	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Influence of enalapril , quinapril and losartan on lipopolysaccharide -LRB- LPS -RRB- - induced serum concentrations of TNF-alpha , IL-1_beta , IL-6 in spontaneously hypertensive rats -LRB- SHR -RRB- .
18176176	0	IL-6	15,19	TNF-alpha	51,60	IL-6	TNF-alpha	3569	7124	Gene	Gene	Interleukin-6|appos|START_ENTITY Interleukin-6|appos|levels levels|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
18976114	0	IL-6	149,153	TNF-alpha	138,147	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	glucose|appos|START_ENTITY glucose|compound|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
18976114	0	IL-6	43,47	TNF-alpha	32,41	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	IL-8|appos|START_ENTITY IL-8|compound|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
19099662	0	IL-6	68,72	TNF-alpha	57,66	IL-6	TNF-alpha	100628202	397086(Tax:9823)	Gene	Gene	expressions|compound|START_ENTITY END_ENTITY|appos|expressions	-LSB- Effect of free hemoglobin on hemorrhagic_shock in pigs : TNF-alpha , IL-6 expressions in serum and rates of MODS after the blood transfusion -RSB- .
19437229	0	IL-6	35,39	TNF-alpha	41,50	IL-6	TNF-alpha	3569	7124	Gene	Gene	homocysteine|appos|START_ENTITY homocysteine|appos|END_ENTITY	Association of maternal serum CRP , IL-6 , TNF-alpha , homocysteine , folic_acid and vitamin_B12 levels with the severity of preeclampsia and fetal birth weight .
20055787	0	IL-6	14,18	TNF-alpha	26,35	IL-6	TNF-alpha	3569	7124	Gene	Gene	HSP-60|compound|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
20103767	0	IL-6	11,15	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	expression|amod|START_ENTITY inhibited|nsubjpass|expression inhibited|advmod|END_ENTITY	TNF-alpha , IL-6 , and IL-1 expression is inhibited by GAS6 in monocytes/macrophages .
20617559	0	IL-6	28,32	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TNF-alpha similarly induces IL-6 and MCP-1 in fibroblasts from colorectal liver metastases and normal liver fibroblasts .
21173731	0	IL-6	0,4	TNF-alpha	6,15	IL-6	TNF-alpha	3569	7124	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	IL-6 , TNF-alpha , IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions .
21591983	0	IL-6	47,51	TNF-alpha	17,26	IL-6	TNF-alpha	3569	7124	Gene	Gene	GPIA|appos|START_ENTITY GPIA|compound|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
23241117	0	IL-6	38,42	TNF-alpha	27,36	IL-6	TNF-alpha	3569	7124	Gene	Gene	RANKL|appos|START_ENTITY RANKL|compound|END_ENTITY	Changes in serum levels of TNF-alpha , IL-6 , OPG , RANKL and their correlation with radiographic and clinical assessment in fragility_fractures and high energy fractures .
23940968	0	IL-6	39,43	TNF-alpha	28,37	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|effect effect|nmod|exercises exercises|nmod|END_ENTITY	-LSB- The effect of exercises on TNF-alpha , IL-6 and adiponectin in different fat diet rats -RSB- .
25530051	0	IL-6	53,57	TNF-alpha	59,68	IL-6	TNF-alpha	3569	7124	Gene	Gene	hs-CRP|appos|START_ENTITY hs-CRP|appos|END_ENTITY	Evaluation of Plasma Concentrations of Homocysteine , IL-6 , TNF-alpha , hs-CRP , and Total Antioxidant Capacity in Patients with End-Stage_Renal_Failure .
25634659	0	IL-6	26,30	TNF-alpha	15,24	IL-6	TNF-alpha	3569	7124	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Association of TNF-alpha , IL-6 and IL-1beta gene polymorphisms with polycystic_ovary_syndrome : a meta-analysis .
25634659	0	IL-6	26,30	TNF-alpha	15,24	IL-6	TNF-alpha	3569	7124	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Association of TNF-alpha , IL-6 and IL-1beta gene polymorphisms with polycystic_ovary_syndrome : a meta-analysis .
7531001	0	IL-6	143,147	TNF-alpha	149,158	IL-6	TNF-alpha	3569	7124	Gene	Gene	CD14|compound|START_ENTITY CD14|appos|END_ENTITY	Infusion of large quantities of autologous blood monocyte-derived macrophages in two cancer patients did not induce increased concentration of IL-6 , TNF-alpha , soluble CD14 and nitrate in blood plasma .
7558123	0	IL-6	16,20	TNF-alpha	22,31	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Cytokine -LRB- IL-8 , IL-6 , TNF-alpha -RRB- and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory_syncytial_virus_infection .
7590883	0	IL-6	75,79	TNF-alpha	35,44	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY relationship|nmod|secretion relationship|nmod|END_ENTITY	A synergistic relationship between TNF-alpha , IL-1_beta , and TGF-beta_1 on IL-6 secretion by the IEC-6 intestinal epithelial cell line .
7921752	0	IL-6	120,124	TNF-alpha	23,32	IL-6	TNF-alpha	3569	7124	Gene	Gene	correlation|nmod|START_ENTITY cytokines|dep|correlation cytokines|appos|IL-6 IL-6|dep|END_ENTITY	Serum cytokines -LRB- IL-6 , TNF-alpha , IL-1_beta and IFN-gamma -RRB- in ankylosing_spondylitis : a close correlation between serum IL-6 and disease activity and severity .
7927487	0	IL-6	76,80	TNF-alpha	82,91	IL-6	TNF-alpha	3569	7124	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Effect of respiratory syncytial virus-antibody complexes on cytokine -LRB- IL-8 , IL-6 , TNF-alpha -RRB- release and respiratory burst in human granulocytes .
8710173	0	IL-6	30,34	TNF-alpha	19,28	IL-6	TNF-alpha	3569	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Early increases in TNF-alpha , IL-6 and IL-1_beta levels following transient cerebral_ischemia in gerbil brain .
8928089	0	IL-6	21,25	TNF-alpha	0,9	IL-6	TNF-alpha	3569	7124	Gene	Gene	upregulation|compound|START_ENTITY suppresses|dobj|upregulation suppresses|nsubj|END_ENTITY	TNF-alpha suppresses IL-6 upregulation of protein S in HepG-2 hepatoma cells .
9191887	0	IL-6	149,153	TNF-alpha	169,178	IL-6	TNF-alpha	3569	7124	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9209124	0	IL-6	34,38	TNF-alpha	73,82	IL-6	TNF-alpha	3569	7124	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	-LSB- The evaluation of interleukin-6 -LRB- IL-6 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- level in peripheral blood of patients with chronic_lower_respiratory_tract_infection -RSB- .
9594206	0	IL-6	35,39	TNF-alpha	24,33	IL-6	TNF-alpha	3569	7124	Gene	Gene	START_ENTITY|nsubj|study study|nmod|IL-1_beta IL-1_beta|appos|END_ENTITY	The study of IL-1_beta , TNF-alpha , IL-6 gene expression and plasma levels on hemodialysis before and after dialyzer reuse .
9718198	0	IL-6	34,38	TNF-alpha	0,9	IL-6	TNF-alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	genes|compound|START_ENTITY expression|nmod|genes increases|dobj|expression increases|nsubj|END_ENTITY	TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2 .8 cells .
17483704	0	IL-6	21,25	TNF-beta	11,19	IL-6	TNF-beta	3569	4049	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
17070836	0	IL-6	84,88	TNFR1	134,139	IL-6	TNFR1	16193(Tax:10090)	21938(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY differences|appos|expression differences|dep|role role|nmod|receptor receptor|appos|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
19527232	0	IL-6	12,16	TNFR1	53,58	IL-6	TNFR1	3569	7132	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of IL-6 , IL-10 , TNF-alpha and its receptors TNFR1 and TNFR2 in the local regulatory system of normal and impaired human spermatogenesis .
24151609	0	IL-6	15,19	TNF_a	0,5	IL-6	TNF a	3569	7124	Gene	Gene	secretion|compound|START_ENTITY regulated|nsubjpass|secretion mediated|ccomp|regulated mediated|nsubj|END_ENTITY	TNF_a mediated IL-6 secretion is regulated by JAK/STAT pathway but not by MEK phosphorylation and AKT phosphorylation in U266 multiple_myeloma cells .
24961464	0	IL-6	17,21	TNF_a	10,15	IL-6	TNF a	3569	7124	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Increased TNF_a , IL-6 and ErbB2 mRNA expression in peripheral blood leukocytes from breast_cancer patients .
11243098	0	IL-6	36,40	TNF_alpha	14,23	IL-6	TNF alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY Expression|appos|mRNA Expression|nmod|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
11243098	0	IL-6	36,40	TNF_alpha	58,67	IL-6	TNF alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY Expression|appos|mRNA Expression|appos|release release|nmod|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
1504836	0	IL-6	18,22	TNF_alpha	0,9	IL-6	TNF alpha	3569	7124	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	TNF_alpha induces IL-6 production by astrocytes but not by microglia .
2067355	0	IL-6	10,14	TNF_alpha	68,77	IL-6	TNF alpha	3569	7124	Gene	Gene	START_ENTITY|acl|secretion secretion|nmod|fibroblasts fibroblasts|nmod|doses doses|nmod|END_ENTITY	Decreased IL-6 secretion by fibroblasts following repeated doses of TNF_alpha or IL-1_alpha : post-transcriptional gene regulation .
7949797	0	IL-6	96,100	TNF_alpha	66,75	IL-6	TNF alpha	3569	7124	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY tumor_necrosis_factor_alpha|appos|END_ENTITY	Diagnostic value of plasma levels of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- and interleukin-6 -LRB- IL-6 -RRB- in newborns with sepsis .
8370344	0	IL-6	57,61	TNF_alpha	46,55	IL-6	TNF alpha	3569	7124	Gene	Gene	IL-1_beta|dep|START_ENTITY IL-1_beta|dep|END_ENTITY	Effect of pentamidine on cytokine -LRB- IL-1_beta , TNF_alpha , IL-6 -RRB- production by human alveolar macrophages in vitro .
8552986	0	IL-6	118,122	TNF_alpha	147,156	IL-6	TNF alpha	3569	7124	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
20595711	0	IL-6	6,10	TNFa	12,16	IL-6	TNFa	100548599	7124	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Serum IL-6 , TNFa levels in snakebite cases occurring in Southern Turkey .
23675187	0	IL-6	0,4	TNFa	18,22	IL-6	TNFa	3569	7124	Gene	Gene	Induction|compound|START_ENTITY Induction|nmod|END_ENTITY	IL-6 Induction by TNFa and IL-1b in an Osteoblast-Like Cell Line .
25436214	0	IL-6	48,52	TNFa	0,4	IL-6	TNFa	3569	7124	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid_arthritis .
15786541	0	IL-6	6,10	TNFalpha	12,20	IL-6	TNFalpha	3569	7124	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Serum IL-6 , TNFalpha and CRP levels in Greek colorectal_cancer patients : prognostic implications .
16316790	0	IL-6	55,59	TNFalpha	0,8	IL-6	TNFalpha	3569	7124	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression utilize|xcomp|induce utilize|nsubj|END_ENTITY	TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics .
18582534	0	IL-6	32,36	TNFalpha	45,53	IL-6	TNFalpha	3569	7124	Gene	Gene	IL-4|dep|START_ENTITY IL-2|dep|IL-4 interleukin|appos|IL-2 interleukin|appos|END_ENTITY	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
16298793	0	IL-6	81,85	TNM	146,149	IL-6	TNM	3569	10178	Gene	Gene	related|nsubjpass|START_ENTITY related|xcomp|END_ENTITY	Head_and_neck_squamous_cell_carcinoma spheroid - and monocyte spheroid-stimulated IL-6 and monocyte_chemotactic_protein-1 secretion are related to TNM stage , inflammatory state and tumor macrophage density .
27010689	0	IL-6	32,36	TRPM7	14,19	IL-6	TRPM7	3569	54822	Gene	Gene	Function|nmod|START_ENTITY Function|compound|END_ENTITY	Regulation of TRPM7 Function by IL-6 through the JAK2-STAT3 Signaling Pathway .
22424785	0	IL-6	99,103	Th2	5,8	IL-6	Th2	16193(Tax:10090)	15111(Tax:10090)	Gene	Gene	deletion|nmod|START_ENTITY function|nmod|deletion function|nsubj|cells cells|compound|END_ENTITY	CD4 + Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene .
11104585	0	IL-6	17,21	Thrombin	0,8	IL-6	Thrombin	16193(Tax:10090)	14061(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Thrombin induces IL-6 but not TNFalpha secretion by mouse mast cells : threshold-level thrombin_receptor and very low level FcepsilonRI signaling synergistically enhance IL-6 secretion .
14719142	0	IL-6	20,24	Thrombin	0,8	IL-6	Thrombin	3569	2147	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Thrombin stimulates IL-6 and IL-8 expression in cytomegalovirus-infected human retinal pigment epithelial cells .
7608566	0	IL-6	17,21	Thrombin	0,8	IL-6	Thrombin	3569	2147	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Thrombin induces IL-6 production in fibroblasts and epithelial cells .
20483734	0	IL-6	47,51	Thymic_stromal_lymphopoietin	0,28	IL-6	Thymic stromal lymphopoietin	3569	85480	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Thymic_stromal_lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells : role of MAPKs -LRB- ERK1/2 , p38 , and JNK -RRB- and STAT3 pathways .
24416310	0	IL-6	8,12	UCP1	52,56	IL-6	UCP1	16193(Tax:10090)	22227(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Role of IL-6 in exercise training - and cold-induced UCP1 expression in subcutaneous white adipose tissue .
9794436	0	IL-6	8,12	VCAM-1	60,66	IL-6	VCAM-1	3569	7412	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression .
12553038	0	IL-6	14,18	VEGF	65,69	IL-6	VEGF	3569	7422	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|dep|involvement involvement|nmod|induction induction|compound|END_ENTITY	Expression of IL-6 receptor in pancreatic_cancer : involvement in VEGF induction .
16009363	0	IL-6	15,19	VEGF	51,55	IL-6	VEGF	3569	7422	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|production production|nmod|END_ENTITY	Involvement of IL-6 in the paracrine production of VEGF in ocular_HSV-1_infection .
16875552	0	IL-6	34,38	VEGF	28,32	IL-6	VEGF	3569	7422	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|significance significance|nmod|END_ENTITY	-LSB- The significance of IGF-1 , VEGF , IL-6 in multiple_myeloma progression -RSB- .
17725274	0	IL-6	136,140	VEGF	79,83	IL-6	VEGF	3569	7422	Gene	Gene	interleukin_6|appos|START_ENTITY vascular_endothelial_growth_factor|appos|interleukin_6 vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
20072693	0	IL-6	25,29	VEGF	14,18	IL-6	VEGF	3569	7422	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|compound|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
21633597	0	IL-6	67,71	VEGF	40,44	IL-6	VEGF	3569	7422	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	-LRB- - -RRB- - Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric_cancer .
23272057	0	IL-6	98,102	VEGF	92,96	IL-6	VEGF	3569	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Hypoxia-induced aggressiveness of pancreatic_cancer cells is due to increased expression of VEGF , IL-6 and miR-21 , which can be attenuated by CDF treatment .
23788086	0	IL-6	67,71	VEGF	49,53	IL-6	VEGF	3569	7422	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Does mobilisation of CD34 + stem cells along with VEGF , angiogenin , IL-6 , IL-8 , and hsCRP levels allow predicting the direction of left ventricular ejection fraction and wall_motion_score_index changes in patients with myocardial_infarction ?
24532586	0	IL-6	100,104	Vav1	26,30	IL-6	Vav1	16193(Tax:10090)	22324(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6 .
19751774	0	IL-6	43,47	Visfatin	0,8	IL-6	Visfatin	3569	10135	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis .
20145198	0	IL-6	38,42	Vpr	6,9	IL-6	Vpr	3569	155807(Tax:11676)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency .
21478032	0	IL-6	0,4	YKL-40	38,44	IL-6	YKL-40	3569	1116	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	IL-6 , but not TNF-a , increases plasma YKL-40 in human subjects .
22132693	0	IL-6	35,39	Zc3h12a	54,61	IL-6	Zc3h12a	3569	80149	Gene	Gene	production|compound|START_ENTITY regulation|nmod|production regulation|nmod|END_ENTITY	Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells .
24434628	0	IL-6	45,49	adiponectin	12,23	IL-6	adiponectin	3569	9370	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	The role of adiponectin in the production of IL-6 , IL-8 , VEGF and MMPs in human endothelial cells and osteoblasts : implications for arthritic_joints .
16397521	0	IL-6	0,4	alpha-smooth_muscle_actin	15,40	IL-6	alpha-smooth muscle actin	16193(Tax:10090)	11475(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	IL-6 modulates alpha-smooth_muscle_actin expression in dermal fibroblasts from IL-6-deficient mice .
11597988	0	IL-6	110,114	angiotensin_II	118,132	IL-6	angiotensin II	3569	183	Gene	Gene	induction|nmod|START_ENTITY involved|nmod|induction involved|nmod|END_ENTITY	ERK and p38 MAPK , but not NF-kappaB , are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin_II in cardiac fibroblasts .
21393356	0	IL-6	57,61	angiotensin_II	94,108	IL-6	angiotensin II	3569	183	Gene	Gene	produce|dobj|START_ENTITY produce|nmod|response response|nmod|END_ENTITY	Highly purified human peripheral blood monocytes produce IL-6 but not TNFalpha in response to angiotensin_II .
26486161	0	IL-6	12,16	angiotensin_II	82,96	IL-6	angiotensin II	16193(Tax:10090)	11606(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of IL-6 in the physiologic versus hypertensive blood pressure actions of angiotensin_II .
16285960	0	IL-6	97,101	angiotensinogen	115,130	IL-6	angiotensinogen	16193(Tax:10090)	183	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen .
19583994	0	IL-6	0,4	angiotensinogen	14,29	IL-6	angiotensinogen	3569	183	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|END_ENTITY	IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells .
9621116	0	IL-6	42,46	angiotensinogen	61,76	IL-6	angiotensinogen	3569	183	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Role of CAAT/enhancer _ binding_protein in IL-6 regulation of angiotensinogen gene expression -RSB- .
9702415	0	IL-6	0,4	annexin_1	16,25	IL-6	annexin 1	3569	301	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	IL-6 stimulates annexin_1 expression and translocation and suggests a new biological role as class II acute phase protein .
9162741	0	IL-6	44,48	apolipoprotein_B	14,30	IL-6	apolipoprotein B	3569	338	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Inhibition of apolipoprotein_B secretion by IL-6 is mediated by EGF or an EGF-like molecule in CaCo-2 cells .
12366710	0	IL-6	141,145	bcl-2	18,23	IL-6	bcl-2	3569	596	Gene	Gene	interleukin-6|appos|START_ENTITY regulation|nmod|interleukin-6 Expression|dep|regulation Expression|nmod|family family|amod|END_ENTITY	Expression of the bcl-2 family of pro- and anti-apoptotic genes in multiple_myeloma and normal plasma cells : regulation during interleukin-6 -LRB- IL-6 -RRB- - induced growth and survival .
12366711	0	IL-6	144,148	bcl-2	84,89	IL-6	bcl-2	3569	596	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Incidence of apoptosis and cell proliferation in multiple_myeloma : correlation with bcl-2 protein expression and serum levels of interleukin-6 -LRB- IL-6 -RRB- and soluble IL-6 receptor .
12476423	0	IL-6	18,22	bcl-2	123,128	IL-6	bcl-2	3569	596	Gene	Gene	Up-expression|nmod|START_ENTITY involved|nsubjpass|Up-expression involved|nmod|regulation regulation|nmod|apoptosis apoptosis|acl|induced induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Up-expression of IL-6 and down-expression of TNFalpha may be involved in the regulation of apoptosis induced by antisense bcl-2 oligodeoxynucleotides -RSB- .
16870148	0	IL-6	0,4	bcl-2	73,78	IL-6	bcl-2	24498(Tax:10116)	24224(Tax:10116)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|induction induction|nmod|mRNA mRNA|amod|END_ENTITY	IL-6 protects enterocytes from hypoxia-induced apoptosis by induction of bcl-2 mRNA and reduction of fas mRNA .
14579272	0	IL-6	100,104	beta4	61,66	IL-6	beta4	3569	10381	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	p38 MAPK is a critical regulator of the constitutive and the beta4 integrin-regulated expression of IL-6 in human normal thymic epithelial cells .
18621420	0	IL-6	19,23	bradykinin	43,53	IL-6	bradykinin	3569	3827	Gene	Gene	expression|compound|START_ENTITY expression|nmod|receptor receptor|compound|END_ENTITY	Bradykinin-induced IL-6 expression through bradykinin B2 receptor , phospholipase C , protein kinase Cdelta and NF-kappaB pathway in human synovial fibroblasts .
20184800	0	IL-6	72,76	bradykinin	19,29	IL-6	bradykinin	3569	3827	Gene	Gene	production|compound|START_ENTITY regulating|dobj|production Cross-talk|advcl|regulating Cross-talk|nmod|END_ENTITY	Cross-talk between bradykinin and epidermal_growth_factor in regulating IL-6 production in human airway_smooth_muscle cells .
10490957	0	IL-6	86,90	cAMP_response_element-binding_protein	124,161	IL-6	cAMP response element-binding protein	24498(Tax:10116)	81646(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	MHC class II engagement in brain endothelial cells induces protein kinase A-dependent IL-6 secretion and phosphorylation of cAMP_response_element-binding_protein .
7780031	0	IL-6	23,27	carcinoembryonic_antigen	45,69	IL-6	carcinoembryonic antigen	3569	1084	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic_antigen -LRB- CEA -RRB- and HLA expression by human colorectal_carcinoma cells : role for endogenous IFN-beta .
22538414	0	IL-6	44,48	caspase-8	64,73	IL-6	caspase-8	3569	841	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Amphotericin_B up-regulates lipid_A-induced IL-6 production via caspase-8 .
10510402	0	IL-6	121,125	gp130	75,80	IL-6	gp130	3569	3572	Gene	Gene	creates|nmod|START_ENTITY creates|nsubj|path path|nmod|activation activation|dep|up-regulation up-regulation|nmod|END_ENTITY	Novel path to activation of vascular smooth_muscle_cells : up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor .
10779772	0	IL-6	0,4	gp130	47,52	IL-6	gp130	3569	3572	Gene	Gene	receptor|nsubj|START_ENTITY receptor|dobj|stimulation stimulation|nmod|END_ENTITY	IL-6 receptor independent stimulation of human gp130 by viral IL-6 .
10779772	0	IL-6	62,66	gp130	47,52	IL-6	gp130	3569	3572	Gene	Gene	receptor|nmod|START_ENTITY receptor|dobj|stimulation stimulation|nmod|END_ENTITY	IL-6 receptor independent stimulation of human gp130 by viral IL-6 .
10843753	0	IL-6	29,33	gp130	35,40	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	interleukin-6|appos|START_ENTITY effect|nmod|interleukin-6 effect|dep|signalling signalling|amod|END_ENTITY	The effect of interleukin-6 -LRB- IL-6 -RRB- / gp130 signalling on biliary epithelial cell growth , in vitro .
11072033	0	IL-6	92,96	gp130	15,20	IL-6	gp130	3569	3572	Gene	Gene	protein|compound|START_ENTITY enhances|nsubj|protein Signal|parataxis|enhances Signal|nmod|END_ENTITY	Signal through gp130 activated by soluble interleukin -LRB- IL -RRB- -6 receptor -LRB- R -RRB- and IL-6 or IL-6R / IL-6 fusion protein enhances ex vivo expansion of human peripheral blood-derived hematopoietic progenitors .
11884403	0	IL-6	31,35	gp130	94,99	IL-6	gp130	3569	3572	Gene	Gene	receptor|appos|START_ENTITY Shedding|nmod|receptor determines|nsubj|Shedding determines|xcomp|induce induce|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
11884403	0	IL-6	79,83	gp130	94,99	IL-6	gp130	3569	3572	Gene	Gene	ability|nmod|START_ENTITY determines|dobj|ability determines|xcomp|induce induce|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
12386808	0	IL-6	87,91	gp130	60,65	IL-6	gp130	3569	3572	Gene	Gene	family|compound|START_ENTITY receptor|nmod|family END_ENTITY|appos|receptor	Cdk9 , a member of the cdc2-like family of kinases , binds to gp130 , the receptor of the IL-6 family of cytokines .
12562400	0	IL-6	49,53	gp130	181,186	IL-6	gp130	3569	3572	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels complexes|dep|circulating complexes|nmod|systemic_juvenile_idiopathic_arthritis systemic_juvenile_idiopathic_arthritis|dep|evidence evidence|nmod|factors factors|acl|interfering interfering|nmod|the the|nmod|END_ENTITY	High circulating levels of biologically inactive IL-6 / SIL-6 receptor complexes in systemic_juvenile_idiopathic_arthritis : evidence for serum factors interfering with the binding to gp130 .
12817006	0	IL-6	157,161	gp130	117,122	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex subunit|amod|END_ENTITY	TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex .
1378269	0	IL-6	15,19	gp130	41,46	IL-6	gp130	3569	3572	Gene	Gene	chain|compound|START_ENTITY chain|appos|END_ENTITY	Enhancement of IL-6 receptor beta chain -LRB- gp130 -RRB- expression by IL-6 , IL-1_and_TNF in human epithelial cells .
1378269	0	IL-6	62,66	gp130	41,46	IL-6	gp130	3569	3572	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Enhancement Enhancement|nmod|chain chain|appos|END_ENTITY	Enhancement of IL-6 receptor beta chain -LRB- gp130 -RRB- expression by IL-6 , IL-1_and_TNF in human epithelial cells .
1427893	0	IL-6	56,60	gp130	90,95	IL-6	gp130	24498(Tax:10116)	25205(Tax:10116)	Gene	Gene	cloning|nmod|START_ENTITY signal|nsubj|cloning signal|dobj|molecule molecule|appos|END_ENTITY	Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule , gp130 .
14627979	0	IL-6	38,42	gp130	112,117	IL-6	gp130	3569	3572	Gene	Gene	triggered|nsubj|START_ENTITY triggered|xcomp|signaling signaling|dobj|cascades cascades|nmod|downregulation downregulation|nmod|END_ENTITY	Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple_myeloma .
14738765	0	IL-6	16,20	gp130	55,60	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY receptor|nsubj|role receptor|dobj|END_ENTITY	Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress .
14978019	0	IL-6	42,46	gp130	72,77	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	family|compound|START_ENTITY tyrosine|nmod|family mutation|nmod|tyrosine cytokine|nsubj|mutation cytokine|dobj|synergizes synergizes|amod|END_ENTITY	The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid_arthritis-like arthritis .
1542794	0	IL-6	4,8	gp130	28,33	IL-6	gp130	3569	3572	Gene	Gene	transducer|compound|START_ENTITY transducer|appos|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
15895091	0	IL-6	81,85	gp130	54,59	IL-6	gp130	3569	3572	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor .
1617725	0	IL-6	82,86	gp130	125,130	IL-6	gp130	3569	3572	Gene	Gene	signal|compound|START_ENTITY transducing|nsubj|signal transducing|dobj|END_ENTITY	CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 .
17997171	0	IL-6	39,43	gp130	70,75	IL-6	gp130	3569	3572	Gene	Gene	transducer|compound|START_ENTITY polymorphism|nmod|transducer polymorphism|parataxis|associated associated|nsubjpass|END_ENTITY	A non-conservative polymorphism in the IL-6 signal transducer -LRB- IL6ST -RRB- / gp130 is associated with myocardial_infarction in a hypertensive population .
18469182	0	IL-6	32,36	gp130	8,13	IL-6	gp130	3569	3572	Gene	Gene	transsignaling|compound|START_ENTITY antagonist|nmod|transsignaling END_ENTITY|appos|antagonist	Soluble gp130 , an antagonist of IL-6 transsignaling , is elevated in uveitis aqueous_humor .
18593565	0	IL-6	52,56	gp130	74,79	IL-6	gp130	3569	3572	Gene	Gene	receptor|compound|START_ENTITY cleavage|nmod|receptor subunit|nsubj|cleavage subunit|dobj|END_ENTITY	Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130 .
18802703	0	IL-6	111,115	gp130	83,88	IL-6	gp130	3569	3572	Gene	Gene	signaling|compound|START_ENTITY inhibitor|nmod|signaling Influence|appos|inhibitor Influence|appos|tocilizumab tocilizumab|nmod|activity activity|nmod|END_ENTITY	Influence of humanized anti-IL-6R antibody , tocilizumab on the activity of soluble gp130 , natural inhibitor of IL-6 signaling .
1915266	0	IL-6	67,71	gp130	91,96	IL-6	gp130	3569	3572	Gene	Gene	transducer|compound|START_ENTITY transducer|appos|END_ENTITY	Leukemia_inhibitory_factor receptor is structurally related to the IL-6 signal transducer , gp130 .
19228423	0	IL-6	38,42	gp130	69,74	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY mutation|nmod|receptor mutation|appos|END_ENTITY	Point mutation of tyrosine 759 of the IL-6 family cytokine receptor , gp130 , augments collagen-induced_arthritis in DBA/1J mice .
19285962	0	IL-6	23,27	gp130	69,74	IL-6	gp130	3569	3572	Gene	Gene	pathway|compound|START_ENTITY inhibits|dobj|pathway inhibits|advcl|depleting depleting|dobj|pools pools|amod|END_ENTITY	Capsaicin inhibits the IL-6 / STAT3 pathway by depleting intracellular gp130 pools through endoplasmic_reticulum_stress .
20309664	0	IL-6	106,110	gp130	111,116	IL-6	gp130	3569	3572	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation protein|acl:relcl|induces protein|parataxis|signaling signaling|nsubj|END_ENTITY	Amyloid-b precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6 / gp130 signaling pathway .
21881215	0	IL-6	52,56	gp130	57,62	IL-6	gp130	3569	3572	Gene	Gene	strategies|nmod|START_ENTITY strategies|parataxis|signaling signaling|nsubj|END_ENTITY	Therapeutic strategies for the clinical blockade of IL-6 / gp130 signaling .
22140267	0	IL-6	59,63	gp130	14,19	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	trans-signaling|compound|START_ENTITY permits|dobj|trans-signaling permits|nsubj|expression expression|amod|END_ENTITY	IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling .
2261637	0	IL-6	39,43	gp130	63,68	IL-6	gp130	3569	3572	Gene	Gene	transducer|compound|START_ENTITY transducer|appos|END_ENTITY	Molecular cloning and expression of an IL-6 signal transducer , gp130 .
23218517	0	IL-6	26,30	gp130	31,36	IL-6	gp130	3569	3572	Gene	Gene	Influence|nmod|START_ENTITY Influence|parataxis|signaling signaling|nsubj|receptor receptor|amod|END_ENTITY	Influence of hypothalamic IL-6 / gp130 receptor signaling on the HPA_axis response to chronic stress .
25103368	0	IL-6	12,16	gp130	17,22	IL-6	gp130	3569	3572	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|parataxis|reveals reveals|nsubj|expression expression|amod|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
25481644	0	IL-6	81,85	gp130	86,91	IL-6	gp130	3569	3572	Gene	Gene	transactivation|compound|START_ENTITY transactivation|amod|END_ENTITY	Sphingosine_kinase_1 contributes to leptin-induced STAT3 phosphorylation through IL-6 / gp130 transactivation in oestrogen receptor-negative breast_cancer .
25722214	0	IL-6	27,31	gp130	32,37	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|Cytokines Cytokines|amod|END_ENTITY	Differential Expression of IL-6 / gp130 Cytokines , Jak-STAT Signaling and Neuroprotection After M ller Cell Ablation in a Transgenic Mouse Model .
26716648	0	IL-6	91,95	gp130	96,101	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	mechanisms|nmod|START_ENTITY mechanisms|dep|inhibition inhibition|amod|END_ENTITY	Sonic hedgehog inhibitors prevent colitis-associated_cancer via orchestrated mechanisms of IL-6 / gp130 inhibition , 15-PGDH induction , Bcl-2 abrogation , and tumorsphere inhibition .
7615645	0	IL-6	45,49	gp130	73,78	IL-6	gp130	3569	3572	Gene	Gene	beta-subunit|compound|START_ENTITY beta-subunit|appos|END_ENTITY	Biosynthetic and glycosylation events of the IL-6 receptor beta-subunit , gp130 .
7649255	0	IL-6	109,113	gp130	133,138	IL-6	gp130	3569	3572	Gene	Gene	transducer|compound|START_ENTITY transducer|appos|END_ENTITY	Leucine-58 in the putative 5th helical region of human interleukin _ -LRB- IL -RRB- -6 is important for activation of the IL-6 signal transducer , gp130 .
7689086	0	IL-6	49,53	gp130	73,78	IL-6	gp130	3569	3572	Gene	Gene	antibodies|nmod|START_ENTITY Preparation|nmod|antibodies signal|nsubj|Preparation signal|dobj|transducer transducer|appos|END_ENTITY	Preparation of monoclonal antibodies against the IL-6 signal transducer , gp130 , that can inhibit IL-6-mediated functions .
7812050	0	IL-6	57,61	gp130	39,44	IL-6	gp130	3569	3572	Gene	Gene	activation|compound|START_ENTITY occur|nmod|activation occur|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes .
7857660	0	IL-6	63,67	gp130	52,57	IL-6	gp130	3569	3572	Gene	Gene	receptor|compound|START_ENTITY signal|nsubj|receptor signal|ccomp|interact interact|nmod|form form|nmod|END_ENTITY	LIF and OM directly interact with a soluble form of gp130 , the IL-6 receptor signal transducing subunit .
7875298	0	IL-6	93,97	gp130	28,33	IL-6	gp130	3569	3572	Gene	Gene	complex|nmod|START_ENTITY formation|nmod|complex responsible|nmod|formation responsible|nsubj|half half|nmod|END_ENTITY	The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6_receptor .
8034658	0	IL-6	157,161	gp130	103,108	IL-6	gp130	3569	3572	Gene	Gene	receptor|compound|START_ENTITY Identification|nmod|receptor Identification|nmod|region region|nmod|domain domain|nmod|END_ENTITY	Identification of a region within the cytoplasmic domain of the interleukin-6 -LRB- IL-6 -RRB- signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor .
8360477	0	IL-6	15,19	gp130	38,43	IL-6	gp130	3569	4827	Gene	Gene	Involvement|nmod|START_ENTITY signal|nsubj|Involvement signal|dobj|END_ENTITY	Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction .
8467812	0	IL-6	37,41	gp130	155,160	IL-6	gp130	3569	3572	Gene	Gene	receptor|compound|START_ENTITY analysis|nmod|receptor analysis|dep|dissociation dissociation|nmod|residues residues|acl|required required|nmod|END_ENTITY	Structure-function analysis of human IL-6 receptor : dissociation of amino_acid residues required for IL-6-binding and for IL-6 signal transduction through gp130 .
8580365	0	IL-6	72,76	gp130	93,98	IL-6	gp130	24498(Tax:10116)	25205(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor oncostatin_M|dobj|expression oncostatin_M|dep|gp80 gp80|appos|END_ENTITY	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
8722639	0	IL-6	24,28	gp130	148,153	IL-6	gp130	3569	3572	Gene	Gene	receptor|compound|START_ENTITY form|nmod|receptor factor|nsubj|form factor|parataxis|antagonistic antagonistic|nsubjpass|form form|nmod|END_ENTITY	The soluble form of the IL-6 receptor -LRB- sIL-6R_alpha -RRB- is a potent growth factor for AIDS-associated Kaposi 's _ sarcoma -LRB- KS -RRB- cells ; the soluble form of gp130 is antagonistic for sIL-6R_alpha-induced AIDS-KS cell growth .
8898103	0	IL-6	118,122	gp130	142,147	IL-6	gp130	3569	3572	Gene	Gene	transducer|compound|START_ENTITY activation|nmod|transducer important|nmod|activation interleukin-6|dep|important END_ENTITY|amod|interleukin-6	Identification of residues in the putative 5th helical region of human interleukin-6 , important for activation of the IL-6 signal transducer , gp130 .
8921254	0	IL-6	99,103	gp130	31,36	IL-6	gp130	24498(Tax:10116)	25205(Tax:10116)	Gene	Gene	CNTF/LIF/OSM|compound|START_ENTITY common|nmod|CNTF/LIF/OSM used|nmod|common component|acl|used END_ENTITY|dep|component	Characteristic localization of gp130 -LRB- the signal-transducing receptor component used in common for IL-6 / IL-11 / CNTF/LIF/OSM -RRB- in the rat brain .
9112331	0	IL-6	23,27	gp130	78,83	IL-6	gp130	3569	3572	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|acl|signalling signalling|nmod|antibodies antibodies|nmod|receptor receptor|amod|END_ENTITY	Specific inhibition of IL-6 signalling with monoclonal antibodies against the gp130 receptor .
9126968	0	IL-6	13,17	gp130	48,53	IL-6	gp130	3569	3572	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|interacting interacting|nmod|kinase kinase|amod|END_ENTITY	Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase .
9295319	0	IL-6	140,144	gp130	67,72	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	sites|nmod|START_ENTITY identification|nmod|sites leads|nmod|identification leads|nsubj|mutagenesis mutagenesis|nmod|part part|nmod|END_ENTITY	Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 -LRB- IL-6 -RRB- .
9517481	0	IL-6	23,27	gp130	14,19	IL-6	gp130	24498(Tax:10116)	25205(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of gp130 by IL-6 / soluble IL-6_receptor induces neuronal differentiation .
9684937	0	IL-6	14,18	gp130	60,65	IL-6	gp130	3569	3572	Gene	Gene	Expression|nmod|START_ENTITY transducer|nsubj|Expression transducer|dobj|mRNAs mRNAs|amod|END_ENTITY	Expression of IL-6 , IL-6 receptor and its signal transducer gp130 mRNAs in megakaryocytic cell lines .
9834125	0	IL-6	8,12	gp130	71,76	IL-6	gp130	3569	3572	Gene	Gene	receptor|compound|START_ENTITY potentiates|nsubj|receptor potentiates|dobj|activity activity|nmod|END_ENTITY	Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses .
9834125	0	IL-6	80,84	gp130	71,76	IL-6	gp130	3569	3572	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|nmod|responses	Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses .
9885909	0	IL-6	92,96	gp130	61,66	IL-6	gp130	3569	3572	Gene	Gene	family|compound|START_ENTITY cytokines|nmod|family Dimerization|nmod|cytokines Dimerization|appos|END_ENTITY	Dimerization and activation of the common transducing chain -LRB- gp130 -RRB- of the cytokines of the IL-6 family by mAb .
9933112	0	IL-6	45,49	gp130	14,19	IL-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	K-7|compound|START_ENTITY signaling|nmod|K-7 END_ENTITY|acl|signaling	Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7 / D-6 accelerates repopulation of lymphoid organs after irradiation .
9951579	0	IL-6	45,49	gp130	39,44	IL-6	gp130	3569	3572	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Functional interaction of the gp80 and gp130 IL-6 receptors in human B cell malignancies .
11884403	0	IL-6	31,35	gp80	47,51	IL-6	gp80	3569	3570	Gene	Gene	receptor|appos|START_ENTITY Shedding|nmod|receptor Shedding|appos|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
11884403	0	IL-6	79,83	gp80	47,51	IL-6	gp80	3569	3570	Gene	Gene	ability|nmod|START_ENTITY determines|dobj|ability determines|nsubj|Shedding Shedding|appos|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
16956953	0	IL-6	124,128	gp80	104,108	IL-6	gp80	3569	3570	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex subunit|amod|END_ENTITY	Signal transduction by human_herpesvirus_8 viral interleukin-6 -LRB- vIL-6 -RRB- is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6 .
7524715	0	IL-6	26,30	gp80	40,44	IL-6	gp80	3569	3570	Gene	Gene	analysis|nmod|START_ENTITY receptor|nsubj|analysis receptor|dobj|molecule molecule|amod|END_ENTITY	Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies .
7537107	0	IL-6	185,189	gp80	200,204	IL-6	gp80	3569	3570	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	IL-6-induced changes in synthesis of alpha 1-acid glycoprotein in human hepatoma Hep3B cells are distinctively regulated by monoclonal antibodies directed against different epitopes of IL-6 receptor -LRB- gp80 -RRB- .
8580365	0	IL-6	72,76	gp80	87,91	IL-6	gp80	24498(Tax:10116)	171459(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor oncostatin_M|dobj|expression oncostatin_M|dep|END_ENTITY	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
9773833	0	IL-6	129,133	granulocyte_colony-stimulating_factor	37,74	IL-6	granulocyte colony-stimulating factor	3569	1440	Gene	Gene	beta|amod|START_ENTITY expression|dep|beta expression|nmod|_ _|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
8195587	0	IL-6	150,154	haptoglobin	17,28	IL-6	haptoglobin	3569	3240	Gene	Gene	treated|nmod|START_ENTITY treated|nsubj|Determination Determination|nmod|expression expression|compound|END_ENTITY	Determination of haptoglobin expression in IL-6 treated HepG2 cells by ELISA and by RNA hybridization -- evaluation of a quantitative method to measure IL-6 .
8195587	0	IL-6	43,47	haptoglobin	17,28	IL-6	haptoglobin	3569	3240	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Determination of haptoglobin expression in IL-6 treated HepG2 cells by ELISA and by RNA hybridization -- evaluation of a quantitative method to measure IL-6 .
3265677	0	IL-6	57,61	hybridoma_growth_factor	13,36	IL-6	hybridoma growth factor	3569	3569	Gene	Gene	Induction|amod|START_ENTITY Induction|nmod|END_ENTITY	Induction of hybridoma_growth_factor -LRB- HGF -RRB- , identical to IL-6 , in human fibroblasts by IL-1 : use of HGF activity in specific and sensitive biological assays for IL-1 and IL-6 .
17189827	0	IL-6	14,18	iNOS	90,94	IL-6	iNOS	16193(Tax:10090)	18126(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nmod|expression expression|nmod|synthase synthase|appos|END_ENTITY	Novel role of IL-6 / SIL-6R signaling in the expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in murine B16 , metastatic melanoma clone F10 .9 , cells .
23886206	0	IL-6	110,114	iNOS	90,94	IL-6	iNOS	16193(Tax:10090)	18126(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
20168253	0	IL-6	76,80	insulin	96,103	IL-6	insulin	3569	3630	Gene	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity .
10566657	0	IL-6	125,129	interferon-gamma	201,217	IL-6	interferon-gamma	3569	3458	Gene	Gene	increases|appos|START_ENTITY increases|nmod|increases increases|nmod|production production|amod|END_ENTITY	Effect of radioactive iodine therapy on cytokine production in Graves ' _ disease : transient increases in interleukin-4 -LRB- IL-4 -RRB- , IL-6 , IL-10 , and tumor_necrosis_factor-alpha , with longer term increases in interferon-gamma production .
19258035	0	IL-6	109,113	interferon-gamma	62,78	IL-6	interferon-gamma	16193(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|nmod|production promotes|dobj|action action|nmod|END_ENTITY	Glycogen_synthase_kinase-3 promotes the synergistic action of interferon-gamma on lipopolysaccharide-induced IL-6 production in RAW264 .7 cells .
7879703	0	IL-6	142,146	interferon-gamma	80,96	IL-6	interferon-gamma	3569	3458	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Human atherosclerotic_abdominal_aortic_aneurysms produce interleukin -LRB- IL -RRB- -6 and interferon-gamma but not IL-2 and IL-4 : the possible role for IL-6 and interferon-gamma in vascular inflammation .
9763578	0	IL-6	103,107	interferon-gamma	52,68	IL-6	interferon-gamma	3569	3458	Gene	Gene	lines|appos|START_ENTITY activated|nmod|lines activated|nmod|END_ENTITY	Fas/APO -1 -LRB- CD95 -RRB- - mediated apoptosis is activated by interferon-gamma and interferon - in interleukin-6 -LRB- IL-6 -RRB- - dependent and IL-6-independent multiple_myeloma cell lines .
8440075	0	IL-6	46,50	interleukin-4	22,35	IL-6	interleukin-4	3569	3565	Gene	Gene	production|compound|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Suppressive effect of interleukin-4 -LRB- IL-4 -RRB- on IL-6 production by adherent rheumatoid synovial cells .
10194431	0	IL-6	23,27	interleukin-6	8,21	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Soluble interleukin-6 -LRB- IL-6 -RRB- receptor with IL-6 stimulates megakaryopoiesis from human CD34 -LRB- + -RRB- cells through glycoprotein _ -LRB- gp -RRB- 130 signaling .
10340760	0	IL-6	34,38	interleukin-6	8,21	IL-6	interleukin-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression .
10541568	0	IL-6	26,30	interleukin-6	11,24	IL-6	interleukin-6	3569	3569	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin-6 -LRB- IL-6 -RRB- on cytotrophoblastic cells .
10580802	0	IL-6	71,75	interleukin-6	56,69	IL-6	interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms at - 174 and in the 3 ' flanking region of interleukin-6 -LRB- IL-6 -RRB- gene in patients with myasthenia_gravis .
10833369	0	IL-6	106,110	interleukin-6	91,104	IL-6	interleukin-6	3569	3569	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Pregnancy-dependent expression of leukaemia_inhibitory_factor -LRB- LIF -RRB- , LIF receptor-beta and interleukin-6 -LRB- IL-6 -RRB- messenger ribonucleic_acids in the porcine female reproductive tract .
11022130	0	IL-6	175,179	interleukin-6	160,173	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11083315	0	IL-6	102,106	interleukin-6	87,100	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 -LRB- IL-6 -RRB- levels .
11766126	0	IL-6	27,31	interleukin-6	12,25	IL-6	interleukin-6	3569	3569	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of interleukin-6 -LRB- IL-6 -RRB- in human_sulfur_mustard -LRB- HD -RRB- toxicology .
11884403	0	IL-6	31,35	interleukin-6	16,29	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
12036196	0	IL-6	64,68	interleukin-6	49,62	IL-6	interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An -LRB- CA -RRB- n dinucleotide repeat polymorphism of the interleukin-6 -LRB- IL-6 -RRB- gene is associated with metacarpal bone_mineral_density in hemodialysis patients .
12414762	0	IL-6	101,105	interleukin-6	86,99	IL-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	NK cells mediate increase of phagocytic activity but not of proinflammatory cytokine -LRB- interleukin-6 -LSB- IL-6 -RSB- , tumor_necrosis_factor_alpha , and IL-12 -RRB- production elicited in splenic macrophages by tilorone treatment of mice during acute systemic_candidiasis .
12633863	0	IL-6	25,29	interleukin-6	10,23	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The human interleukin-6 -LRB- IL-6 -RRB- receptor exists as a preformed dimer in the plasma membrane .
12829785	0	IL-6	54,58	interleukin-6	40,53	IL-6	interleukin-6	3569	3569	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Hexameric structure and assembly of the interleukin-6 / IL-6 alpha-receptor/gp130 complex .
14592424	0	IL-6	49,53	interleukin-6	8,21	IL-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Chronic interleukin-6 -LRB- IL-6 -RRB- treatment increased IL-6 secretion and induced insulin resistance in adipocyte : prevention by rosiglitazone .
14668030	0	IL-6	35,39	interleukin-6	20,33	IL-6	interleukin-6	3569	3569	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Platelet counts and interleukin-6 -LRB- IL-6 -RRB- promoter polymorphism in patients with Gaucher_disease .
1479760	0	IL-6	99,103	interleukin-6	84,97	IL-6	interleukin-6	3569	3569	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Establishment of a new human renal_cancer cell line -LRB- TC-1 -RRB- and its productivity of interleukin-6 -LRB- IL-6 -RRB- -RSB- .
15086213	0	IL-6	60,64	interleukin-6	45,58	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Effect of octreotide administration on serum interleukin-6 -LRB- IL-6 -RRB- levels of patients with acute edematous_pancreatitis .
15319170	0	IL-6	55,59	interleukin-6	40,53	IL-6	interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The C-174G promoter polymorphism of the interleukin-6 -LRB- IL-6 -RRB- gene that affects insulin sensitivity in Caucasians is not involved in the pathogenesis of Taiwanese_type_2_diabetes mellitus .
15455667	0	IL-6	24,28	interleukin-6	9,22	IL-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	-LSB- Role of interleukin-6 -LRB- IL-6 -RRB- in the pathogenesis of combined radiation/thermal injuries -RSB- .
1586734	0	IL-6	128,132	interleukin-6	26,39	IL-6	interleukin-6	16193(Tax:10090)	3569	Gene	Gene	restores|nmod|START_ENTITY restores|nsubj|Introduction Introduction|nmod|receptor receptor|amod|END_ENTITY	Introduction of the human interleukin-6 -LRB- IL-6 -RRB- receptor in murine IL-3-dependent hematopoietic cells restores responsiveness to IL-6 .
1586734	0	IL-6	41,45	interleukin-6	26,39	IL-6	interleukin-6	16193(Tax:10090)	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Introduction of the human interleukin-6 -LRB- IL-6 -RRB- receptor in murine IL-3-dependent hematopoietic cells restores responsiveness to IL-6 .
16927176	0	IL-6	31,35	interleukin-6	16,29	IL-6	interleukin-6	3569	3569	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of interleukin-6 -LRB- IL-6 -RRB- in breast_cancer -LRB- review -RRB- .
16956953	0	IL-6	124,128	interleukin-6	49,62	IL-6	interleukin-6	3569	4961449(Tax:37296)	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex modulated|nmod|subunit modulated|nsubjpass|Signal Signal|acl|transduction transduction|nmod|END_ENTITY	Signal transduction by human_herpesvirus_8 viral interleukin-6 -LRB- vIL-6 -RRB- is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6 .
17283116	0	IL-6	38,42	interleukin-6	23,36	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Establishment of a new interleukin-6 -LRB- IL-6 -RRB- receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor .
17303263	0	IL-6	41,45	interleukin-6	26,39	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Prognostic value of serum interleukin-6 -LRB- IL-6 -RRB- levels in long term care .
17500617	0	IL-6	33,37	interleukin-6	7,20	IL-6	interleukin-6	3569	3569	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Plasma interleukin-6 and soluble IL-6 receptors are associated with psychological_well-being in aging women .
18030875	0	IL-6	41,45	interleukin-6	26,39	IL-6	interleukin-6	3569	3569	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	-LSB- Clinical significance of interleukin-6 -LRB- IL-6 -RRB- as a prognostic factor of cancer_disease -RSB- .
19261461	0	IL-6	44,48	interleukin-6	29,42	IL-6	interleukin-6	3569	3569	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Highly specific detection of interleukin-6 -LRB- IL-6 -RRB- protein using combination tapered fiber-optic biosensor dip-probe .
20627334	0	IL-6	77,81	interleukin-6	62,75	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Muscle strength , muscle balance , physical function and plasma interleukin-6 -LRB- IL-6 -RRB- levels in elderly women with knee_osteoarthritis -LRB- OA -RRB- .
2107195	0	IL-6	57,61	interleukin-6	42,55	IL-6	interleukin-6	3569	3569	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Normal mitogen-induced suppression of the interleukin-6 -LRB- IL-6 -RRB- response and its deficiency in systemic_lupus_erythematosus .
21127061	0	IL-6	28,32	interleukin-6	13,26	IL-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nrf2 induces interleukin-6 -LRB- IL-6 -RRB- expression via an antioxidant response element within the IL-6 promoter .
21277639	0	IL-6	32,36	interleukin-6	17,30	IL-6	interleukin-6	3569	3569	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Distributions of interleukin-6 -LRB- IL-6 -RRB- promoter and metallothionein_2A -LRB- MT2A -RRB- core promoter region gene polymorphisms and their associations with aging in Turkish population .
21523377	0	IL-6	37,41	interleukin-6	22,35	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Regulation of soluble interleukin-6 -LRB- IL-6 -RRB- receptor release from corneal epithelial cells and its role in the ocular surface .
21607393	0	IL-6	42,46	interleukin-6	27,40	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Origin of heterogeneity of interleukin-6 -LRB- IL-6 -RRB- levels in malignant_pleural_effusions .
21911244	0	IL-6	30,34	interleukin-6	15,28	IL-6	interleukin-6	3569	3569	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Effects of the interleukin-6 -LRB- IL-6 -RRB- polymorphism on toxic metal and trace element levels in placental tissues .
21976681	0	IL-6	160,164	interleukin-6	145,158	IL-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Efnb1 and Efnb2 proteins regulate thymocyte development , peripheral T cell differentiation , and antiviral immune responses and are essential for interleukin-6 -LRB- IL-6 -RRB- signaling .
22135910	0	IL-6	25,29	interleukin-6	10,23	IL-6	interleukin-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin-6 -LRB- IL-6 -RRB- on the vascular smooth muscle contraction in abdominal aorta of rats with streptozotocin-induced diabetes .
22157761	0	IL-6	99,103	interleukin-6	84,97	IL-6	interleukin-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_3|appos|START_ENTITY signal_transducer_and_activator_of_transcription_3|amod|END_ENTITY	Inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- attenuates interleukin-6 -LRB- IL-6 -RRB- - induced collagen synthesis and resultant hypertrophy in rat heart .
22457007	0	IL-6	84,88	interleukin-6	69,82	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Baseline anti-citrullinated peptide antibody -LRB- ACPA -RRB- titers and serum interleukin-6 -LRB- IL-6 -RRB- levels possibly predict progression_of_bone_destruction in early stages of rheumatoid_arthritis -LRB- ERA -RRB- .
22773460	0	IL-6	37,41	interleukin-6	22,35	IL-6	interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Impact of the -174 G/C interleukin-6 -LRB- IL-6 -RRB- gene polymorphism on the risk of paediatric ischemic_stroke , its symptoms and outcome .
23398417	0	IL-6	76,80	interleukin-6	61,74	IL-6	interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning , expression and regulation analysis of the interleukin-6 -LRB- IL-6 -RRB- gene in goose adipocytes .
2392639	1	IL-6	108,112	interleukin-6	65,78	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Raised serum interleukin-6 -LRB- IL-6 -RRB- levels and effects of IL-6 and anti-IL-6 on in vitro erythropoiesis .
24709011	0	IL-6	79,83	interleukin-6	64,77	IL-6	interleukin-6	3569	3569	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TLR5 activation by flagellin induces doxorubicin_resistance via interleukin-6 -LRB- IL-6 -RRB- expression in two multiple myeloma cells .
26255596	0	IL-6	39,43	interleukin-6	24,37	IL-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Glycoprotein130 -LRB- Gp130 -RRB- / interleukin-6 -LRB- IL-6 -RRB- signalling in osteoclasts promotes bone formation in periosteal and trabecular bone .
7559874	0	IL-6	23,27	interleukin-6	8,21	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Soluble interleukin-6 -LRB- IL-6 -RRB- receptor in the sera of pregnant women forms a complex with IL-6 and augments human chorionic gonadotropin production by normal human trophoblasts through binding to the IL-6 signal transducer .
7768358	0	IL-6	23,27	interleukin-6	8,21	IL-6	interleukin-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Soluble interleukin-6 -LRB- IL-6 -RRB- receptor augments central effects of IL-6 in vivo .
8074468	0	IL-6	31,35	interleukin-6	16,29	IL-6	interleukin-6	3569	3569	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Augmentation of interleukin-6 -LRB- IL-6 -RRB- expression in squamous_carcinoma cells and normal human keratinocytes treated with recombinant anti-neoplastic_protein -LRB- ACP -RRB- .
8325885	0	IL-6	48,52	interleukin-6	24,37	IL-6	interleukin-6	3569	3569	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Modulation of the human interleukin-6 promoter -LRB- IL-6 -RRB- and transcription factor C/EBP _ beta -LRB- NF-IL6 -RRB- activity by p53 species .
8344369	0	IL-6	37,41	interleukin-6	22,35	IL-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Increased circulating interleukin-6 -LRB- IL-6 -RRB- activity in endotoxin-challenged mice pretreated with anti-IL-6 antibody is due to IL-6 accumulated in antigen-antibody complexes .
8372675	0	IL-6	33,37	interleukin-6	18,31	IL-6	interleukin-6	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum and urinary interleukin-6 -LRB- IL-6 -RRB- levels as predicting factors of Kawasaki_disease activity .
8417972	0	IL-6	40,44	interleukin-6	25,38	IL-6	interleukin-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Absence of expression of interleukin-6 -LRB- IL-6 -RRB- mRNA in regenerating rat liver .
8621406	0	IL-6	64,68	interleukin-6	49,62	IL-6	interleukin-6	3569	3569	Gene	Gene	signal|appos|START_ENTITY signal|amod|END_ENTITY	A di-leucine motif and an upstream serine in the interleukin-6 -LRB- IL-6 -RRB- signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor .
9769329	0	IL-6	56,60	interleukin-6	41,54	IL-6	interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The effect of novel polymorphisms in the interleukin-6 -LRB- IL-6 -RRB- gene on IL-6 transcription and plasma IL-6 levels , and an association with systemic-onset juvenile_chronic_arthritis .
10214897	0	IL-6	40,44	interleukin_6	25,38	IL-6	interleukin 6	3569	3569	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Quantitative analysis of interleukin_6 -LRB- IL-6 -RRB- in patients with IgA_nephropathy after tonsillectomy .
10385616	0	IL-6	75,79	interleukin_6	60,73	IL-6	interleukin 6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Central injection of nicotine increases hepatic and splenic interleukin_6 -LRB- IL-6 -RRB- mRNA expression and plasma IL-6 levels in mice : involvement of the peripheral sympathetic nervous system .
1311016	0	IL-6	23,27	interleukin_6	8,21	IL-6	interleukin 6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of interleukin_6 -LRB- IL-6 -RRB- in protection from lethal irradiation and in endocrine responses to IL-1 and tumor_necrosis_factor .
17317452	0	IL-6	42,46	interleukin_6	27,40	IL-6	interleukin 6	3569	3569	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Associations of the plasma interleukin_6 -LRB- IL-6 -RRB- levels with disability and mortality in the elderly in the Treviso Longeva -LRB- Trelong -RRB- study .
22509361	0	IL-6	59,63	interleukin_6	44,57	IL-6	interleukin 6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of -174 G > C and -572 G > C in the interleukin_6 -LRB- IL-6 -RRB- gene and coronary_heart_disease risk : a meta-analysis of 27 research studies .
24886605	0	IL-6	41,45	interleukin_6	26,39	IL-6	interleukin 6	3569	3569	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Genetic modulation of the interleukin_6 -LRB- IL-6 -RRB- system in patients with advanced gastric_cancer : a background for an alternative target therapy .
3263278	0	IL-6	25,29	interleukin_6	10,23	IL-6	interleukin 6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin_6 -LRB- IL-6 -RRB- on the differentiation and proliferation of murine and human hemopoietic progenitors .
7744784	0	IL-6	28,32	interleukin_6	13,26	IL-6	interleukin 6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of interleukin_6 -LRB- IL-6 -RRB- by hypoxia in vascular cells .
8627341	0	IL-6	73,77	interleukin_6	58,71	IL-6	interleukin 6	3569	3569	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- and interleukin_6 -LRB- IL-6 -RRB- mRNA in adult human astrocytes : comparison with adult microglia and fetal astrocytes .
8666898	0	IL-6	136,140	interleukin_6	28,41	IL-6	interleukin 6	16193(Tax:10090)	3569	Gene	Gene	transgenic_mice|nmod|START_ENTITY sensitization|nmod|transgenic_mice function|dep|sensitization function|nmod|receptor receptor|amod|END_ENTITY	The function of the soluble interleukin_6 -LRB- IL-6 -RRB- receptor in vivo : sensitization of human soluble IL-6_receptor transgenic_mice towards IL-6 and prolongation of the plasma half-life of IL-6 .
8666898	0	IL-6	185,189	interleukin_6	28,41	IL-6	interleukin 6	16193(Tax:10090)	3569	Gene	Gene	half-life|nmod|START_ENTITY sensitization|nmod|half-life function|dep|sensitization function|nmod|receptor receptor|amod|END_ENTITY	The function of the soluble interleukin_6 -LRB- IL-6 -RRB- receptor in vivo : sensitization of human soluble IL-6_receptor transgenic_mice towards IL-6 and prolongation of the plasma half-life of IL-6 .
8666898	0	IL-6	43,47	interleukin_6	28,41	IL-6	interleukin 6	16193(Tax:10090)	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The function of the soluble interleukin_6 -LRB- IL-6 -RRB- receptor in vivo : sensitization of human soluble IL-6_receptor transgenic_mice towards IL-6 and prolongation of the plasma half-life of IL-6 .
9375862	0	IL-6	23,27	interleukin_6	8,21	IL-6	interleukin 6	3569	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Soluble interleukin_6 -LRB- IL-6 -RRB- receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies .
9722935	0	IL-6	23,27	interleukin_6	8,21	IL-6	interleukin 6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Soluble interleukin_6 -LRB- IL-6 -RRB- receptor influences the expression of the protooncogene junB and the production of fibrinogen in the HepG2 human hepatoma cell line and primary rat hepatocytes .
7519422	0	IL-6	34,38	junB	63,67	IL-6	junB	24498(Tax:10116)	24517(Tax:10116)	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|amod|END_ENTITY	Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins .
8637711	0	IL-6	31,35	junB	60,64	IL-6	junB	3569	3726	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|amod|END_ENTITY	IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein -LRB- s -RRB- .
15216955	0	IL-6	26,30	lactoferrin	11,22	IL-6	lactoferrin	16193(Tax:10090)	17002(Tax:10090)	Gene	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of lactoferrin on IL-6 production by peritoneal and alveolar cells in cyclophosphamide-treated mice .
17617622	0	IL-6	15,19	leptin	46,52	IL-6	leptin	3569	3952	Gene	Gene	production|compound|START_ENTITY mediated|nsubjpass|production mediated|nmod|receptor receptor|compound|END_ENTITY	Leptin-induced IL-6 production is mediated by leptin receptor , insulin receptor substrate-1 , phosphatidylinositol 3-kinase , Akt , NF-kappaB , and p300 pathway in microglia .
23108993	0	IL-6	137,141	mTOR	74,78	IL-6	mTOR	100008733(Tax:9986)	21977(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY expression|dep|mRNA expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
26101800	0	IL-6	4,8	miR-21	27,33	IL-6	miR-21	3569	406991	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|pathway pathway|nmod|END_ENTITY	The IL-6 / STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes .
26252635	0	IL-6	0,4	miR-21	50,56	IL-6	miR-21	3569	406991	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
26252635	0	IL-6	0,4	miR-21	50,56	IL-6	miR-21	3569	406991	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
16466693	0	IL-6	39,43	neuromedin_U	17,29	IL-6	neuromedin U	16193(Tax:10090)	56183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	The neuropeptide neuromedin_U promotes IL-6 production from macrophages and endotoxin shock .
11022130	0	IL-6	76,80	oncostatin_M	128,140	IL-6	oncostatin M	3569	5008	Gene	Gene	interleukin-6|dep|START_ENTITY cytokines|amod|interleukin-6 cytokines|dep|IL-6 IL-6|appos|interleukin-11 interleukin-11|appos|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11022130	0	IL-6	98,102	oncostatin_M	128,140	IL-6	oncostatin M	3569	5008	Gene	Gene	START_ENTITY|appos|interleukin-11 interleukin-11|appos|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
12391243	0	IL-6	69,73	oncostatin_M	13,25	IL-6	oncostatin M	3569	5008	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression Secretion|dep|regulation Secretion|nmod|END_ENTITY	Secretion of oncostatin_M by infiltrating neutrophils : regulation of IL-6 and chemokine expression in human mesothelial cells .
1542794	0	IL-6	4,8	oncostatin_M	38,50	IL-6	oncostatin M	3569	5008	Gene	Gene	transducer|compound|START_ENTITY transducer|dep|receptor receptor|compound|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
1918953	0	IL-6	14,18	oncostatin_M	33,45	IL-6	oncostatin M	3569	5008	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of IL-6 expression by oncostatin_M .
23797667	0	IL-6	119,123	oncostatin_M	24,36	IL-6	oncostatin M	16193(Tax:10090)	18413(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY promotes|nmod|role promotes|nsubj|expression expression|nmod|END_ENTITY	Pulmonary expression of oncostatin_M -LRB- OSM -RRB- promotes inducible BALT formation independently of IL-6 , despite a role for IL-6 in OSM-driven pulmonary_inflammation .
23797667	0	IL-6	94,98	oncostatin_M	24,36	IL-6	oncostatin M	16193(Tax:10090)	18413(Tax:10090)	Gene	Gene	formation|nmod|START_ENTITY promotes|dobj|formation promotes|nsubj|expression expression|nmod|END_ENTITY	Pulmonary expression of oncostatin_M -LRB- OSM -RRB- promotes inducible BALT formation independently of IL-6 , despite a role for IL-6 in OSM-driven pulmonary_inflammation .
25103368	0	IL-6	12,16	oncostatin_M	108,120	IL-6	oncostatin M	3569	5008	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|parataxis|reveals reveals|ccomp|lack lack|dobj|receptor receptor|compound|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
25103368	0	IL-6	12,16	oncostatin_M	158,170	IL-6	oncostatin M	3569	5008	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|parataxis|reveals reveals|ccomp|lack lack|xcomp|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
8003632	0	IL-6	85,89	oncostatin_M	20,32	IL-6	oncostatin M	3569	5008	Gene	Gene	expression|compound|START_ENTITY Interaction|nmod|expression Interaction|nmod|END_ENTITY	Interaction between oncostatin_M , interleukin 1 and prostaglandin_E2 in induction of IL-6 expression in human fibroblasts .
8274294	0	IL-6	169,173	oncostatin_M	120,132	IL-6	oncostatin M	3569	5008	Gene	Gene	interleukin_6|appos|START_ENTITY coresistant|nmod|interleukin_6 coresistant|nsubj|Selection Selection|amod|resistant resistant|nmod|effects effects|nmod|END_ENTITY	Selection and characterization of a variant of human melanoma cell line , A375 resistant to growth inhibitory effects of oncostatin_M -LRB- OM -RRB- : coresistant to interleukin_6 -LRB- IL-6 -RRB- .
8580365	0	IL-6	72,76	oncostatin_M	10,22	IL-6	oncostatin M	24498(Tax:10116)	289747(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor END_ENTITY|dobj|expression	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
24650887	0	IL-6	138,142	p-c-JUN_and_JNK	219,234	IL-6	p-c-JUN and JNK	16193(Tax:10090)	26419(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
10445852	0	IL-6	51,55	p38	32,35	IL-6	p38	3569	1432	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3 .
10620700	0	IL-6	52,56	p38	12,15	IL-6	p38	3569	1432	Gene	Gene	production|amod|START_ENTITY kinase|nmod|production kinase|nsubj|role role|nmod|protein protein|amod|END_ENTITY	The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha - or IL-1beta-stimulated rheumatoid synovial fibroblasts .
10762076	0	IL-6	40,44	p38	100,103	IL-6	p38	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	interleukin-6|appos|START_ENTITY Regulation|nmod|interleukin-6 Regulation|dep|role role|nmod|kinase kinase|amod|END_ENTITY	Regulation of macrophage interleukin-6 -LRB- IL-6 -RRB- and IL-10 expression by prostaglandin_E2 : the role of p38 mitogen-activated protein kinase .
14634061	0	IL-6	43,47	p38	68,71	IL-6	p38	3569	5594	Gene	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	Acute ethanol exposure inhibits macrophage IL-6 production : role of p38 and ERK1/2 MAPK .
15034939	0	IL-6	68,72	p38	87,90	IL-6	p38	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|kinase kinase|amod|END_ENTITY	Interleukin _ -LRB- IL -RRB- -17 enhances tumor_necrosis_factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts .
15769552	0	IL-6	0,4	p38	90,93	IL-6	p38	3569	1432	Gene	Gene	expression|compound|START_ENTITY depends|nsubj|expression depends|nmod|mitogen mitogen|amod|END_ENTITY	IL-6 expression induced by adenosine A2b receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C. Adenosine binds to a class of G-protein coupled receptors , which are further distinguished as A -LRB- 1 -RRB- , A -LRB- 2a -RRB- , A -LRB- 2b -RRB- and A -LRB- 3 -RRB- adenosine receptors .
16147857	0	IL-6	70,74	p38	22,25	IL-6	p38	3569	5594	Gene	Gene	induction|compound|START_ENTITY promote|dobj|induction activates|xcomp|promote activates|dobj|kinase kinase|nummod|END_ENTITY	Substance_P activates p38 mitogen-activated protein kinase to promote IL-6 induction in human dental pulp fibroblasts .
16197469	0	IL-6	13,17	p38	94,97	IL-6	p38	3569	1432	Gene	Gene	Induction|nmod|START_ENTITY regulated|nsubjpass|Induction regulated|nmod|MAPK MAPK|amod|END_ENTITY	Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-kappaB .
16272363	0	IL-6	98,102	p38	27,30	IL-6	p38	3569	5594	Gene	Gene	overexpression|compound|START_ENTITY leads|nmod|overexpression leads|nsubj|activation activation|nmod|MAPKs MAPKs|compound|END_ENTITY	Constitutive activation of p38 and ERK1/2 MAPKs in epithelial cells of myasthenic thymus leads to IL-6 and RANTES overexpression : effects on survival and migration of peripheral T and B cells .
16571868	0	IL-6	46,50	p38	28,31	IL-6	p38	3569	5594	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia .
17204543	0	IL-6	76,80	p38	125,128	IL-6	p38	3569	1432	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|advcl|MAPK MAPK|csubj|decreasing decreasing|dobj|HGF HGF|dep|roles roles|nmod|END_ENTITY	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF : the roles of p38 , ERK , and JNK MAPK signaling .
17825250	0	IL-6	45,49	p38	64,67	IL-6	p38	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|kinase kinase|amod|END_ENTITY	Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts .
18025155	0	IL-6	43,47	p38	97,100	IL-6	p38	3569	1432	Gene	Gene	production|compound|START_ENTITY production|nmod|macrophages macrophages|nmod|MAPK MAPK|amod|END_ENTITY	Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp -RCB- B activity .
20631726	0	IL-6	38,42	p38	47,50	IL-6	p38	3569	1432	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells , similar to that seen in the psoriatic_condition .
21161531	0	IL-6	98,102	p38	14,17	IL-6	p38	3569	5594	Gene	Gene	expression|amod|START_ENTITY block|dobj|expression block|nsubj|Inhibitors Inhibitors|nmod|MAPkinase MAPkinase|compound|END_ENTITY	Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen_sulphide block constitutive and IL-1b-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28 / I2 .
23177780	0	IL-6	0,4	p38	79,82	IL-6	p38	3569	1432	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|amod|END_ENTITY	IL-6 promotes the expression of vascular_endothelial_growth_factor through the p38 signalling pathway in hypertrophied adenoids in children .
23206705	0	IL-6	41,45	p38	0,3	IL-6	p38	3569	1432	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|alpha alpha|amod|END_ENTITY	p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac_fibroblasts .
23438872	0	IL-6	48,52	p38	69,72	IL-6	p38	24498(Tax:10116)	81649(Tax:10116)	Gene	Gene	release|compound|START_ENTITY release|nmod|pathway pathway|amod|END_ENTITY	High fatty_acids modulate P2X -LRB- 7 -RRB- expression and IL-6 release via the p38 MAPK pathway in PC12 cells .
24227780	0	IL-6	27,31	p38	48,51	IL-6	p38	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway .
24650887	0	IL-6	138,142	p38	209,212	IL-6	p38	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|p-c-JUN_and_JNK p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
26760196	0	IL-6	109,113	p38	88,91	IL-6	p38	24498(Tax:10116)	81649(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hydrogen_sulfide prevents OGD/R-induced apoptosis by suppressing the phosphorylation of p38 and secretion of IL-6 in PC12 cells .
15195698	0	IL-6	36,40	p38_MAPK	0,8	IL-6	p38 MAPK	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induced|dobj|expression IL-1beta|acl|induced regulates|dobj|IL-1beta regulates|nsubj|END_ENTITY	p38_MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts .
15316034	0	IL-6	35,39	p38_MAPK	128,136	IL-6	p38 MAPK	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	production|compound|START_ENTITY potentiates|dobj|production potentiates|parataxis|involvement involvement|nmod|END_ENTITY	Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation : involvement of p38_MAPK .
16229818	0	IL-6	17,21	p38_MAPK	37,45	IL-6	p38 MAPK	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	AICAR stimulates IL-6 production via p38_MAPK in cardiac fibroblasts in adult mice : a possible role for AMPK .
17114490	0	IL-6	31,35	p38_MAPK	62,70	IL-6	p38 MAPK	16193(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|effects effects|nmod|END_ENTITY	Annexin_1 negatively regulates IL-6 expression via effects on p38_MAPK and MAPK_phosphatase-1 .
9647240	0	IL-6	14,18	p53	32,35	IL-6	p53	3569	7157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of IL-6 signaling by p53 : STAT3 - and STAT5-masking in p53-Val135-containing human hepatoma Hep3B cell lines .
22906876	0	IL-6	65,69	promyelocytic_leukemia_protein	15,45	IL-6	promyelocytic leukemia protein	3569	5371	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Association of promyelocytic_leukemia_protein with expression of IL-6 and resistance to treatment in multiple_myeloma .
19242540	0	IL-6	67,71	prostate_specific_membrane_antigen	4,38	IL-6	prostate specific membrane antigen	3569	2346	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The prostate_specific_membrane_antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways .
14733913	0	IL-6	0,4	serum_amyloid_A	65,80	IL-6	serum amyloid A	3569	6287	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|induction induction|nmod|END_ENTITY	IL-6 plays a critical role in the synergistic induction of human serum_amyloid_A -LRB- SAA -RRB- gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system .
25484067	0	IL-6	46,50	serum_amyloid_A	69,84	IL-6	serum amyloid A	16193(Tax:10090)	111345(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	An affibody-adalimumab hybrid blocks combined IL-6 and TNF-triggered serum_amyloid_A secretion in vivo .
7790046	0	IL-6	51,55	serum_amyloid_A	26,41	IL-6	serum amyloid A	3569	6287	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of serum_amyloid_A -LRB- SAA -RRB- by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line .
10749580	0	IL-6	120,124	stem_cell_factor	50,66	IL-6	stem cell factor	3569	4254	Gene	Gene	receptor|amod|START_ENTITY _|dobj|receptor _|nsubj|Expansion Expansion|nmod|cells cells|nmod|END_ENTITY	Expansion of human NOD/SCID-repopulating cells by stem_cell_factor , Flk2/Flt3 _ ligand , thrombopoietin , IL-6 , and soluble IL-6 receptor .
12626585	0	IL-6	23,27	suppressor_of_cytokine_signaling_3	98,132	IL-6	suppressor of cytokine signaling 3	3569	9021	Gene	Gene	STAT3|nmod|START_ENTITY Activation|nmod|STAT3 modulated|nsubjpass|Activation modulated|nmod|END_ENTITY	Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor_of_cytokine_signaling_3 .
26774658	0	IL-6	0,4	suppressor_of_cytokine_signaling_3	91,125	IL-6	suppressor of cytokine signaling 3	3569	9021	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor_of_cytokine_signaling_3 .
25674084	0	IL-6	42,46	syntaxin_3	11,21	IL-6	syntaxin 3	3569	6809	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for syntaxin_3 in the secretion of IL-6 from dendritic cells following activation of toll-like receptors .
17725274	0	IL-6	136,140	tumor_necrosis_factor	86,107	IL-6	tumor necrosis factor	3569	7124	Gene	Gene	interleukin_6|appos|START_ENTITY vascular_endothelial_growth_factor|appos|interleukin_6 vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
18176176	0	IL-6	15,19	tumor_necrosis_factor-alpha	22,49	IL-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	Interleukin-6|appos|START_ENTITY Interleukin-6|appos|levels levels|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
9773833	0	IL-6	129,133	tumor_necrosis_factor-alpha	76,103	IL-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	beta|amod|START_ENTITY expression|dep|beta expression|nmod|_ _|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
7954438	0	IL-6	146,150	tumor_necrosis_factor_alpha	165,192	IL-6	tumor necrosis factor alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
12776188	0	IL-6	71,75	vFLIP	48,53	IL-6	vFLIP	3569	4961494(Tax:37296)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus encoded vFLIP induces cellular IL-6 expression : the role of the NF-kappaB and JNK/AP1 pathways .
23177780	0	IL-6	0,4	vascular_endothelial_growth_factor	32,66	IL-6	vascular endothelial growth factor	3569	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	IL-6 promotes the expression of vascular_endothelial_growth_factor through the p38 signalling pathway in hypertrophied adenoids in children .
17404025	0	IL-6	57,61	vascular_endothelial_growth_factor-D	8,44	IL-6	vascular endothelial growth factor-D	24498(Tax:10116)	360457(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of vascular_endothelial_growth_factor-D -LRB- VEGF-D -RRB- on IL-6 expression in cerulein-stimulated pancreatic acinar cells .
7545714	0	IL-6	0,4	vitronectin	16,27	IL-6	vitronectin	24498(Tax:10116)	29169(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	IL-6 stimulates vitronectin gene expression in vivo .
17496315	0	IL-6R	18,23	CD4	47,50	IL-6R	CD4	16194(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY blockade|nmod|signaling induces|nsubj|blockade induces|dobj|apoptosis apoptosis|compound|END_ENTITY	Local blockade of IL-6R signaling induces lung CD4 + T cell apoptosis in a murine model of asthma via regulatory T cells .
17675459	0	IL-6R	46,51	CD4	94,97	IL-6R	CD4	16194(Tax:10090)	12504(Tax:10090)	Gene	Gene	trans-signaling|nmod|START_ENTITY abrogates|nsubj|trans-signaling abrogates|dobj|induction induction|nmod|FoxP3 FoxP3|nmod|cells cells|compound|END_ENTITY	Cutting edge : trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4 + CD25 T cells .
18490707	0	IL-6R	22,27	CD4	82,85	IL-6R	CD4	3570	920	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|ectodomain ectodomain|acl|shedding shedding|nmod|cells cells|compound|END_ENTITY	Cutting edge : soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells .
18490707	0	IL-6R	43,48	CD4	82,85	IL-6R	CD4	3570	920	Gene	Gene	ectodomain|compound|START_ENTITY ectodomain|acl|shedding shedding|nmod|cells cells|compound|END_ENTITY	Cutting edge : soluble IL-6R is produced by IL-6R ectodomain shedding in activated CD4 T cells .
20019339	0	IL-6R	68,73	CD4	88,91	IL-6R	CD4	3570	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|Cells Cells|compound|END_ENTITY	Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4 + T Cells .
20083667	0	IL-6R	20,25	CD4	8,11	IL-6R	CD4	16194(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Loss of CD4 + T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells .
12479108	0	IL-6R	90,95	EGFR	84,88	IL-6R	EGFR	3570	1956	Gene	Gene	PCNA|appos|START_ENTITY PCNA|compound|END_ENTITY	-LSB- Relationship between recurrence and metastasis of gastric_cancer and expression of EGFR , IL-6R , PCNA , and DI -RSB- .
10722865	0	IL-6R	46,51	IL-6	84,88	IL-6R	IL-6	3570	3569	Gene	Gene	line|nummod|START_ENTITY respond|nsubj|line respond|nmod|END_ENTITY	Soluble interleukin-6_receptor -LRB- sIL-6R -RRB- makes IL-6R negative T cell line respond to IL-6 ; it inhibits TNF production .
10976001	0	IL-6R	31,36	IL-6	3,7	IL-6R	IL-6	3570	3569	Gene	Gene	IL-6_soluble_receptor|dep|START_ENTITY protein|amod|IL-6_soluble_receptor induces|nsubj|protein END_ENTITY|parataxis|induces	An IL-6 / IL-6_soluble_receptor -LRB- IL-6R -RRB- hybrid protein -LRB- H-IL-6 -RRB- induces EPO-independent erythroid differentiation in human CD34 -LRB- + -RRB- cells .
12476893	0	IL-6R	42,47	IL-6	37,41	IL-6R	IL-6	3570	3569	Gene	Gene	system|compound|START_ENTITY system|dep|-LSB- -LSB-|dobj|influence influence|nmod|corticosteroids corticosteroids|nmod|END_ENTITY	-LSB- The influence of corticosteroids on IL-6 / IL-6R system in patients with Graves ' _ ophthalmopathy -RSB- .
12553555	0	IL-6R	66,71	IL-6	32,36	IL-6R	IL-6	3570	3569	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Co-expression of interleukin-6 -LRB- IL-6 -RRB- and interleukin-6_receptor -LRB- IL-6R -RRB- in thyroid nodules is associated with co-expression of CD30_ligand / CD30 receptor .
12578631	0	IL-6R	20,25	IL-6	15,19	IL-6R	IL-6	3570	3569	Gene	Gene	Treatment|compound|START_ENTITY Treatment|dep|-LSB- -LSB-|dobj|Strategy Strategy|nmod|END_ENTITY	-LSB- A Strategy of IL-6 / IL-6R System Mediates Targeted Treatment for Leukemia -RSB- An inevitable trend for the development of new treatment of leukemia is to use targeted strategy .
15345308	0	IL-6R	116,121	IL-6	111,115	IL-6R	IL-6	3570	3569	Gene	Gene	complex|compound|START_ENTITY Development|dep|complex Development|nmod|gp130 gp130|nmod|END_ENTITY	Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6 / IL-6R complex and its competitive inhibition .
16257998	0	IL-6R	95,100	IL-6	90,94	IL-6R	IL-6	3570	3569	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	All-trans_retinoic_acid modulates radiation-induced proliferation of lung fibroblasts via IL-6 / IL-6R system .
16732516	0	IL-6R	107,112	IL-6	102,106	IL-6R	IL-6	3570	3569	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|/ /|amod|END_ENTITY	Chrysin inhibits lipopolysaccharide-induced angiogenesis via down-regulation of VEGF/VEGFR -2 -LRB- KDR -RRB- and IL-6 / IL-6R pathways .
18337485	0	IL-6R	5,10	IL-6	0,4	IL-6R	IL-6	16194(Tax:10090)	16193(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY plays|nsubj|axis END_ENTITY|appos|plays	IL-6 / IL-6R axis plays a critical role in acute_kidney_injury .
20083667	0	IL-6R	20,25	IL-6	79,83	IL-6R	IL-6	16194(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Loss|nmod|expression underlines|nsubj|Loss underlines|dobj|role role|nmod|trans trans|compound|END_ENTITY	Loss of CD4 + T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells .
22469658	0	IL-6R	70,75	IL-6	8,12	IL-6R	IL-6	101069438	503562(Tax:31033)	Gene	Gene	signaling|nmod|START_ENTITY promotes|nmod|signaling promotes|nsubj|END_ENTITY	Teleost IL-6 promotes antibody production through STAT3 signaling via IL-6R and gp130 .
23658720	0	IL-6R	14,19	IL-6	9,13	IL-6R	IL-6	3570	3569	Gene	Gene	signaling|compound|START_ENTITY promotes|nsubj|signaling END_ENTITY|parataxis|promotes	Enhanced IL-6 / IL-6R signaling promotes growth and malignant properties in EBV-infected premalignant and cancerous nasopharyngeal epithelial cells .
25856562	0	IL-6R	66,71	IL-6	36,40	IL-6R	IL-6	3570	3569	Gene	Gene	/|dobj|START_ENTITY /|nsubj|effects effects|nmod|interleukin-6 interleukin-6|appos|END_ENTITY	Antitumor effects of interleukin-6 -LRB- IL-6 -RRB- / interleukin-6_receptor -LRB- IL-6R -RRB- signaling pathway inhibition in clear_cell_carcinoma_of_the_ovary .
26616855	0	IL-6R	38,43	IL-6	33,37	IL-6R	IL-6	3570	3569	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling inhibition|parataxis|induces inhibition|nmod|END_ENTITY	Diacerein-mediated inhibition of IL-6 / IL-6R signaling induces apoptotic effects on breast_cancer .
26929249	0	IL-6R	57,62	IL-6	84,88	IL-6R	IL-6	3570	3569	Gene	Gene	antagonist|compound|START_ENTITY Chikusetsusaponin|appos|antagonist inhibits|nsubj|Chikusetsusaponin inhibits|dobj|STAT3 STAT3|compound|END_ENTITY	Chikusetsusaponin a butyl_ester -LRB- CS - ___ a-Be -RRB- , a novel IL-6R antagonist , inhibits IL-6 / STAT3 signaling pathway and induces cancer cell apoptosis .
8180786	0	IL-6R	63,68	IL-6	29,33	IL-6R	IL-6	24499(Tax:10116)	24498(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Expression of interleukin-6 -LRB- IL-6 -RRB- and interleukin-6_receptor -LRB- IL-6R -RRB- mRNAs in rat brain during postnatal development .
8510817	0	IL-6R	76,81	IL-6	42,46	IL-6R	IL-6	24499(Tax:10116)	24498(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Differential expression of interleukin-6 -LRB- IL-6 -RRB- and interleukin-6_receptor -LRB- IL-6R -RRB- mRNAs in rat hypothalamus .
8816254	0	IL-6R	64,69	IL-6	39,43	IL-6R	IL-6	24499(Tax:10116)	24498(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	Postnatal expression of interleukin-6 -LRB- IL-6 -RRB- and IL-6_receptor -LRB- IL-6R -RRB- mRNAs in rat sympathetic and sensory ganglia .
9651120	0	IL-6R	73,78	IL-6	44,48	IL-6R	IL-6	24499(Tax:10116)	24498(Tax:10116)	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	The expressions of mRNAs for interleukin-6 -LRB- IL-6 -RRB- and the IL-6_receptor -LRB- IL-6R -RRB- in the rat hypothalamus and midbrain during restraint stress .
15306846	0	IL-6R	36,41	IL-6_receptor	21,34	IL-6R	IL-6 receptor	3570	3570	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the IL-6_receptor -LRB- IL-6R -RRB- gene : strong evidence that serum levels of soluble IL-6R are genetically influenced .
22469658	0	IL-6R	70,75	STAT3	50,55	IL-6R	STAT3	101069438	101070968	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Teleost IL-6 promotes antibody production through STAT3 signaling via IL-6R and gp130 .
26929249	0	IL-6R	57,62	STAT3	89,94	IL-6R	STAT3	3570	6774	Gene	Gene	antagonist|compound|START_ENTITY Chikusetsusaponin|appos|antagonist inhibits|nsubj|Chikusetsusaponin inhibits|dobj|END_ENTITY	Chikusetsusaponin a butyl_ester -LRB- CS - ___ a-Be -RRB- , a novel IL-6R antagonist , inhibits IL-6 / STAT3 signaling pathway and induces cancer cell apoptosis .
10397166	0	IL-6R	50,55	interleukin-6_receptor	26,48	IL-6R	interleukin-6 receptor	3570	3570	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Generation of ` truncated ' interleukin-6_receptor -LRB- IL-6R -RRB- mRNA by alternative splicing ; a possible source of soluble IL-6R .
26484199	0	IL-6Ra	94,100	IL-6	89,93	IL-6Ra	IL-6	3570	3569	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6 / IL-6Ra axis .
26561568	0	IL-6Ra	57,63	IL-6	16,20	IL-6Ra	IL-6	16194(Tax:10090)	16193(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY signaling|nmod|cleavage END_ENTITY|acl|signaling	ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Ra from the cell surface of leukocytes during inflammatory responses .
27097661	0	IL-6Ra	68,74	IL-6	51,55	IL-6Ra	IL-6	16194(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Receptor Receptor|compound|END_ENTITY	Preproglucagon -LRB- PPG -RRB- neurons in the hindbrain have IL-6 Receptor a -LRB- IL-6Ra -RRB- and show Ca2 + influx in response to IL-6 .
26484199	0	IL-6Ra	94,100	STAT3	68,73	IL-6Ra	STAT3	3570	6774	Gene	Gene	axis|compound|START_ENTITY activation|nmod|axis activation|nummod|END_ENTITY	Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6 / IL-6Ra axis .
19553536	0	IL-6_and_TNF_via_glucocorticoid-induced_leucine_zipper	31,85	Annexin-1	0,9	IL-6 and TNF via glucocorticoid-induced leucine zipper	Annexin-1	16193(Tax:10090)	16952(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Annexin-1 regulates macrophage IL-6_and_TNF_via_glucocorticoid-induced_leucine_zipper .
12517948	0	IL-6_and_matrix_metalloproteinase-1	0,35	p21	91,94	IL-6 and matrix metalloproteinase-1	p21	16193(Tax:10090)	12575(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	IL-6_and_matrix_metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts .
21700295	0	IL-6_receptor	39,52	IL-6	22,26	IL-6 receptor	IL-6	3570	3569	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Association of plasma IL-6 and soluble IL-6_receptor levels with the Asp358Ala polymorphism of the IL-6_receptor gene in schizophrenic patients .
23136552	0	IL-6_receptor	37,50	IL-6	0,4	IL-6 receptor	IL-6	3570	3569	Gene	Gene	trans-signaling|nmod|START_ENTITY trans-signaling|compound|END_ENTITY	IL-6 trans-signaling via the soluble IL-6_receptor : importance for the pro-inflammatory activities of IL-6 .
15306846	0	IL-6_receptor	21,34	IL-6R	36,41	IL-6 receptor	IL-6R	3570	3570	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the IL-6_receptor -LRB- IL-6R -RRB- gene : strong evidence that serum levels of soluble IL-6R are genetically influenced .
23564454	0	IL-6_receptor	60,73	interleukin_6	8,21	IL-6 receptor	interleukin 6	3570	3569	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Minimal interleukin_6 -LRB- IL-6 -RRB- receptor stalk composition for IL-6_receptor shedding and IL-6 classic signaling .
17671508	0	IL-6r	48,53	interleukin_6_receptor	24,46	IL-6r	interleukin 6 receptor	3570	3570	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common variant of the interleukin_6_receptor -LRB- IL-6r -RRB- gene increases IL-6r and IL-6 levels , without other inflammatory effects .
7507002	0	IL-7	0,4	B7/BB1	35,41	IL-7	B7/BB1	3574	941	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IL-7 induces surface expression of B7/BB1 on pre-B cells and an associated increase in their costimulatory effects on T cell proliferation .
9252127	0	IL-7	49,53	Bcl-2	58,63	IL-7	Bcl-2	16196(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression .
15922716	0	IL-7	11,15	CD25	48,52	IL-7	CD25	3574	3559	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|induction induction|nmod|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
20693259	0	IL-7	45,49	CD25	11,15	IL-7	CD25	3574	3559	Gene	Gene	receptor|compound|START_ENTITY lack|dobj|receptor cells|ccomp|lack cells|compound|END_ENTITY	Numbers of CD25 + Foxp3 + T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients .
15922716	0	IL-7	11,15	CD4	96,99	IL-7	CD4	3574	920	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|compound|END_ENTITY	Effects of IL-7 and dexamethasone : induction of CD25 , the high affinity IL-2_receptor , on human CD4 + cells .
19008454	0	IL-7	0,4	CD4	45,48	IL-7	CD4	3574	920	Gene	Gene	sustains|nsubj|START_ENTITY sustains|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	IL-7 sustains CD31 expression in human naive CD4 + T cells and preferentially expands the CD31 + subset in a PI3K-dependent manner .
21673554	0	IL-7	32,36	CD4	38,41	IL-7	CD4	3574	920	Gene	Gene	response|nmod|START_ENTITY proliferate|nmod|response proliferate|nsubj|cells cells|compound|END_ENTITY	Despite an impaired response to IL-7 , CD4 + EM T cells from HIV-positive patients proliferate normally in response to IL-15 and its superagonist , RLI .
19002156	0	IL-7	44,48	CD40	0,4	IL-7	CD40	3574	958	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	CD40 regulates human dendritic cell-derived IL-7 production that , in turn , contributes to CD8 -LRB- + -RRB- T-cell antigen-specific expansion .
1717551	0	IL-7	11,15	CD56	44,48	IL-7	CD56	3574	4684	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|compound|END_ENTITY	Effects of IL-7 and IL-2 on highly enriched CD56 + natural killer cells .
8204885	0	IL-7	99,103	CDw127	92,98	IL-7	CDw127	3574	3575	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Growth inhibitory and agonistic signals of interleukin-7 -LRB- IL-7 -RRB- can be mediated through the CDw127 IL-7 receptor .
9175915	0	IL-7	107,111	CDw127	39,45	IL-7	CDw127	3574	3575	Gene	Gene	insufficient|nmod|START_ENTITY insufficient|nsubj|Absence Absence|nmod|IL-7_receptor IL-7_receptor|acl:relcl|indicates indicates|nsubj|END_ENTITY	Absence of the IL-7_receptor component CDw127 indicates that gamma -LRB- c -RRB- expression alone is insufficient for IL-7 to modulate human neutrophil responses .
23129754	0	IL-7	0,4	FOXP3	54,59	IL-7	FOXP3	3574	50943	Gene	Gene	abrogates|nsubj|START_ENTITY abrogates|dobj|activity activity|nmod|cells cells|compound|END_ENTITY	IL-7 abrogates suppressive activity of human CD4 + CD25 + FOXP3 + regulatory T cells and allows expansion of alloreactive and autoreactive T cells .
24947990	0	IL-7	57,61	FOXP3	94,99	IL-7	FOXP3	3574	50943	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4 + FOXP3 - cells versus regulatory T cells : a whole blood perspective .
21745722	0	IL-7	0,4	FoxP3	24,29	IL-7	FoxP3	16196(Tax:10090)	20371(Tax:10090)	Gene	Gene	maintains|dep|START_ENTITY maintains|nsubj|END_ENTITY	IL-7 uniquely maintains FoxP3 -LRB- + -RRB- adaptive Treg cells that reverse diabetes in NOD mice via integrin-b7-dependent localization .
19841165	0	IL-7	108,112	Foxp3	74,79	IL-7	Foxp3	16196(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|regulation regulation|nmod|autoimmune_disease autoimmune_disease|nmod|differentiation differentiation|nmod|END_ENTITY	Thymic regulation of autoimmune_disease by accelerated differentiation of Foxp3 + regulatory T cells through IL-7 signaling pathway .
20693259	0	IL-7	45,49	Foxp3	16,21	IL-7	Foxp3	3574	50943	Gene	Gene	receptor|compound|START_ENTITY lack|dobj|receptor cells|ccomp|lack cells|compound|END_ENTITY	Numbers of CD25 + Foxp3 + T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients .
22593613	0	IL-7	11,15	Foxp3	43,48	IL-7	Foxp3	16196(Tax:10090)	20371(Tax:10090)	Gene	Gene	requirement|compound|START_ENTITY requirement|nmod|END_ENTITY	An in vivo IL-7 requirement for peripheral Foxp3 + regulatory T cell homeostasis .
8569177	0	IL-7	118,122	IFN-alpha	131,140	IL-7	IFN-alpha	16196(Tax:10090)	111654(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8568231	0	IL-7	0,4	IFN-gamma	48,57	IL-7	IFN-gamma	3574	3458	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	IL-7 differentially modulates the expression of IFN-gamma and IL-4 in activated human T lymphocytes by transcriptional and post-transcriptional mechanisms .
7954438	0	IL-7	152,156	IL-10	158,163	IL-7	IL-10	16196(Tax:10090)	16153(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8569177	0	IL-7	118,122	IL-10	124,129	IL-7	IL-10	16196(Tax:10090)	16153(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
24790790	0	IL-7	66,70	IL-15	71,76	IL-7	IL-15	3574	3600	Gene	Gene	response|amod|START_ENTITY response|compound|END_ENTITY	Sustained CD4 -LRB- + -RRB- T cell-driven lymphopenia without a compensatory IL-7 / IL-15 response among high-grade glioma patients treated with radiation and temozolomide .
25200954	0	IL-7	22,26	IL-18	0,5	IL-7	IL-18	16196(Tax:10090)	16173(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IL-18 synergizes with IL-7 to drive slow proliferation of naive CD8 T cells by costimulating self-peptide-mediated TCR signals .
25780034	0	IL-7	27,31	IL-18	0,5	IL-7	IL-18	16196(Tax:10090)	16173(Tax:10090)	Gene	Gene	Expansion|amod|START_ENTITY Acts|nmod|Expansion Acts|compound|END_ENTITY	IL-18 Acts in Synergy with IL-7 To Promote Ex Vivo Expansion of T Lymphoid Progenitor Cells .
20497296	0	IL-7	32,36	IL-1beta	12,20	IL-7	IL-1beta	3574	3553	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	The role of IL-1beta in reduced IL-7 production by stromal and epithelial cells : a model for impaired_T-cell_numbers_in_the_gut_during_HIV-1_infection .
12354940	0	IL-7	26,30	IL-2	0,4	IL-7	IL-2	3574	3558	Gene	Gene	alpha|amod|START_ENTITY expression|amod|alpha regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes .
15259908	0	IL-7	0,4	IL-2	47,51	IL-7	IL-2	3574	3558	Gene	Gene	START_ENTITY|dep|regulation regulation|dep|immunotherapy immunotherapy|compound|END_ENTITY	IL-7 / IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients .
15259908	0	IL-7	5,9	IL-2	47,51	IL-7	IL-2	3574	3558	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|immunotherapy immunotherapy|compound|END_ENTITY	IL-7 / IL-7 receptor system regulation following IL-2 immunotherapy in HIV-infected patients .
1531763	0	IL-7	0,4	IL-2	82,86	IL-7	IL-2	3574	3558	Gene	Gene	induces|nsubj|START_ENTITY induces|parataxis|CD8 CD8|dep|precursors precursors|nmod|pathway pathway|compound|END_ENTITY	IL-7 induces proliferation of CD3 - / low CD4 - CD8 - human thymocyte precursors by an IL-2 independent pathway .
15577633	0	IL-7	0,4	IL-2	99,103	IL-7	IL-2	3574	3558	Gene	Gene	levels|amod|START_ENTITY increased|nsubjpass|levels increased|nmod|therapy therapy|compound|END_ENTITY	IL-7 and Flt-3L plasma levels are increased during highly active antiretroviral therapy-associated IL-2 therapy .
18981091	0	IL-7	39,43	IL-2	33,37	IL-7	IL-2	3574	3558	Gene	Gene	induce|nsubj|START_ENTITY cytokines|ccomp|induce cytokines|xcomp|END_ENTITY	The common_gamma-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 induce the expression of programmed death-1 and its ligands .
19198835	0	IL-7	90,94	IL-2	205,209	IL-7	IL-2	16196(Tax:10090)	16183(Tax:10090)	Gene	Gene	IL-15|compound|START_ENTITY ionomycin|nmod|IL-15 activated|nmod|ionomycin lymphocytes|acl|activated Incubation|nmod|lymphocytes increases|nsubj|Incubation increases|dobj|yield yield|nmod|cells cells|amod|capable capable|advcl|inducing inducing|advcl|culture culture|nmod|END_ENTITY	Incubation of antigen-sensitized T lymphocytes activated with bryostatin_1 + ionomycin in IL-7 _ + _ IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2 .
19950184	0	IL-7	0,4	IL-2	20,24	IL-7	IL-2	3574	3558	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|cells cells|amod|END_ENTITY	IL-7 is superior to IL-2 for ex vivo expansion of tumour-specific CD4 -LRB- + -RRB- T cells .
20190192	0	IL-7	0,4	IL-2	31,35	IL-7	IL-2	16196(Tax:10090)	16183(Tax:10090)	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic_lymphoma in immunodeficient mice .
21552852	0	IL-7	128,132	IL-2	78,82	IL-7	IL-2	3574	3558	Gene	Gene	induced|nmod|START_ENTITY generated|parataxis|induced generated|nmod|END_ENTITY	Comparison of adherent lymphokine-activated killer -LRB- a-lak -RRB- cells generated by IL-2 and IL-7 - cellular modifications induced by IL-7 .
22422881	0	IL-7	105,109	IL-2	99,103	IL-7	IL-2	3574	3558	Gene	Gene	associated|nsubjpass|START_ENTITY associated|ccomp|cytokines cytokines|xcomp|END_ENTITY	Antigen-independent induction of Tim-3 expression on human T cells by the common y-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway .
23994891	0	IL-7	33,37	IL-2	53,57	IL-7	IL-2	3574	3558	Gene	Gene	cultured|nmod|START_ENTITY cultured|nmod|exhibit exhibit|compound|END_ENTITY	Cord blood T cells cultured with IL-7 in addition to IL-2 exhibit a higher degree of polyfunctionality and superior proliferation potential .
8128231	0	IL-7	61,65	IL-2	32,36	IL-7	IL-2	3574	3558	Gene	Gene	complexes|compound|START_ENTITY chain|nmod|complexes chain|nsubj|participation participation|nmod|gamma gamma|compound|END_ENTITY	Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes .
8569177	0	IL-7	118,122	IL-2	106,110	IL-7	IL-2	16196(Tax:10090)	16183(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|compound|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
8622984	0	IL-7	66,70	IL-2	15,19	IL-7	IL-2	16196(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY induce|dobj|receptors induce|nsubj|Interleukin_2 Interleukin_2|appos|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- and interleukin_7 -LRB- IL-7 -RRB- reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes .
8916956	0	IL-7	30,34	IL-2	23,27	IL-7	IL-2	3574	3558	Gene	Gene	interleukin-2|amod|START_ENTITY interleukin-2|appos|END_ENTITY	Role of interleukin-2 -LRB- IL-2 -RRB- , IL-7 , and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma_c transduced severe combined immunodeficiency X1 bone marrow cells .
17898044	0	IL-7	22,26	IL-21	0,5	IL-7	IL-21	3574	59067	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells .
7596167	0	IL-7	229,233	IL-4	224,228	IL-7	IL-4	3574	3565	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Heterogeneity of proliferative responses of human B cell precursor acute_lymphoblastic_leukemia -LRB- BCP-ALL -RRB- cells to interleukin_7 -LRB- IL-7 -RRB- : no correlation with immunoglobulin gene status and expression of IL-7 receptor or IL-2 / IL-4 / IL-7 receptor common_gamma_chain genes .
7954438	0	IL-7	152,156	IL-4	140,144	IL-7	IL-4	16196(Tax:10090)	16189(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|compound|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
8569177	0	IL-7	118,122	IL-4	112,116	IL-7	IL-4	16196(Tax:10090)	16189(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|appos|END_ENTITY	Role of neutrophils and lymphocytes in inhibition of a mouse mammary_adenocarcinoma engineered to release IL-2 , IL-4 , IL-7 , IL-10 , IFN-alpha , IFN-gamma , and TNF-alpha .
7954438	0	IL-7	152,156	IL-6	146,150	IL-7	IL-6	16196(Tax:10090)	16193(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
17956896	0	IL-7	0,4	IL-7	15,19	IL-7	IL-7	3574	3574	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	IL-7 decreases IL-7 receptor alpha -LRB- CD127 -RRB- expression and induces the shedding of CD127 by human CD8 + T cells .
17956896	0	IL-7	15,19	IL-7	0,4	IL-7	IL-7	3574	3574	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	IL-7 decreases IL-7 receptor alpha -LRB- CD127 -RRB- expression and induces the shedding of CD127 by human CD8 + T cells .
2785567	0	IL-7	58,62	IL-7	81,85	IL-7	IL-7	16196(Tax:10090)	16196(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming_growth_factor-beta .
2785567	0	IL-7	81,85	IL-7	58,62	IL-7	IL-7	16196(Tax:10090)	16196(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming_growth_factor-beta .
8176200	1	IL-7	55,59	IL-7	72,76	IL-7	IL-7	3574	3574	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Human B cell_lines constitutively secrete IL-7 and express IL-7 receptors .
8176200	1	IL-7	72,76	IL-7	55,59	IL-7	IL-7	3574	3574	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Human B cell_lines constitutively secrete IL-7 and express IL-7 receptors .
12594950	0	IL-7	10,14	IL-7R	15,20	IL-7	IL-7R	3574	3575	Gene	Gene	START_ENTITY|parataxis|provides provides|nsubj|signaling signaling|compound|END_ENTITY	Transient IL-7 / IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin_heavy_chain gene rearrangements .
14561163	0	IL-7	91,95	IL-7R	96,101	IL-7	IL-7R	3574	3575	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Therapeutic approaches to chronic intestinal_inflammation by specific targeting of mucosal IL-7 / IL-7R signal pathway .
21209878	0	IL-7	37,41	IL-7R	43,48	IL-7	IL-7R	3574	3575	Gene	Gene	interleukin-7|appos|START_ENTITY /|nsubj|interleukin-7 /|dobj|levels levels|compound|END_ENTITY	Increased bone marrow interleukin-7 -LRB- IL-7 -RRB- / IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4 + gain on antiviral therapy .
23610371	0	IL-7	0,4	IL-7R	118,123	IL-7	IL-7R	16196(Tax:10090)	16197(Tax:10090)	Gene	Gene	START_ENTITY|appos|augment augment|nmod|END_ENTITY	IL-7 / anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R .
7543134	0	IL-7	90,94	IL-7R	28,33	IL-7	IL-7R	3574	3575	Gene	Gene	receptor|compound|START_ENTITY derived|nmod|receptor derived|nsubj|control control|nmod|cells cells|compound|END_ENTITY	Cell cycle control of c-kit + IL-7R + B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium .
23207282	0	IL-7	0,4	IL-7Ra	19,25	IL-7	IL-7Ra	3574	3575	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	IL-7 downregulates IL-7Ra expression in human CD8 T cells by two independent mechanisms .
1517567	0	IL-7	0,4	IL-8	36,40	IL-7	IL-8	3574	3576	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	IL-7 up-regulates the expression of IL-8 from resting and stimulated human blood monocytes .
26218271	0	IL-7	125,129	IRAK-M	101,107	IL-7	IRAK-M	16196(Tax:10090)	73914(Tax:10090)	Gene	Gene	Mediated|nmod|START_ENTITY Mediated|nmod|END_ENTITY	Tolerance and Cross-Tolerance following Toll-Like_Receptor _ -LRB- TLR -RRB- -4 _ and _ -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes .
26923586	0	IL-7	0,4	SAMHD1	13,19	IL-7	SAMHD1	3574	25939	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	IL-7 Induces SAMHD1 Phosphorylation in CD4 + T Lymphocytes , Improving Early Steps of HIV-1 Life Cycle .
9798684	0	IL-7	32,36	abl	15,18	IL-7	abl	16196(Tax:10090)	11350(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of abl and raf with IL-7 signaling pathway and transformation of pre-B cells from resistant mice .
18981091	0	IL-7	39,43	common_gamma-chain	4,22	IL-7	common gamma-chain	3574	3561	Gene	Gene	induce|nsubj|START_ENTITY cytokines|ccomp|induce cytokines|nsubj|END_ENTITY	The common_gamma-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 induce the expression of programmed death-1 and its ligands .
9190922	0	IL-7	53,57	common_gamma-chain	19,37	IL-7	common gamma-chain	3574	3561	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Association of the common_gamma-chain with the human IL-7 receptor is modulated by T cell activation .
21209281	0	IL-7	42,46	hepatocyte_growth_factor	47,71	IL-7	hepatocyte growth factor	16196(Tax:10090)	15234(Tax:10090)	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	In vivo administration of the recombinant IL-7 / hepatocyte_growth_factor b hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation .
2804342	0	IL-7	58,62	interleukin-7	43,56	IL-7	interleukin-7	16196(Tax:10090)	16196(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	A stimulatory effect of recombinant murine interleukin-7 -LRB- IL-7 -RRB- on B-cell colony formation and an inhibitory effect of IL-1_alpha .
11396992	0	IL-7	29,33	interleukin_7	14,27	IL-7	interleukin 7	3574	3574	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of interleukin_7 -LRB- IL-7 -RRB- mRNA and protein in the normal adult_human_liver : implications for extrathymic T cell development .
1678354	0	IL-7	30,34	interleukin_7	15,28	IL-7	interleukin 7	3574	3574	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of interleukin_7 -LRB- IL-7 -RRB- on human bone marrow in vitro .
8589262	0	IL-7	30,34	interleukin_7	15,28	IL-7	interleukin 7	3574	3574	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of interleukin_7 -LRB- IL-7 -RRB- with glycosaminoglycans and its biological relevance .
25161318	0	IL-7	36,40	miR-17	99,105	IL-7	miR-17	3574	406952	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	T_cell_receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus_kinase_1 .
12490655	0	IL-7	0,4	receptor_activator_of_nuclear_factor_kappa_B_ligand	47,98	IL-7	receptor activator of nuclear factor kappa B ligand	16196(Tax:10090)	21943(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	IL-7 induces bone_loss in vivo by induction of receptor_activator_of_nuclear_factor_kappa_B_ligand and tumor_necrosis_factor_alpha from T cells .
7954438	0	IL-7	152,156	tumor_necrosis_factor_alpha	165,192	IL-7	tumor necrosis factor alpha	16196(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
18566388	0	IL-7R	15,20	CD25	29,33	IL-7R	CD25	16197(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18566388	0	IL-7R	15,20	CD4	25,28	IL-7R	CD4	16197(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
18566388	0	IL-7R	15,20	Foxp3	34,39	IL-7R	Foxp3	16197(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	A function for IL-7R for CD4 + CD25 + Foxp3 + T regulatory cells .
12594950	0	IL-7R	15,20	IL-7	10,14	IL-7R	IL-7	3575	3574	Gene	Gene	signaling|compound|START_ENTITY provides|nsubj|signaling END_ENTITY|parataxis|provides	Transient IL-7 / IL-7R signaling provides a mechanism for feedback inhibition of immunoglobulin_heavy_chain gene rearrangements .
14561163	0	IL-7R	96,101	IL-7	91,95	IL-7R	IL-7	3575	3574	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Therapeutic approaches to chronic intestinal_inflammation by specific targeting of mucosal IL-7 / IL-7R signal pathway .
21209878	0	IL-7R	43,48	IL-7	37,41	IL-7R	IL-7	3575	3574	Gene	Gene	levels|compound|START_ENTITY /|dobj|levels /|nsubj|interleukin-7 interleukin-7|appos|END_ENTITY	Increased bone marrow interleukin-7 -LRB- IL-7 -RRB- / IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4 + gain on antiviral therapy .
23610371	0	IL-7R	118,123	IL-7	0,4	IL-7R	IL-7	16197(Tax:10090)	16196(Tax:10090)	Gene	Gene	augment|nmod|START_ENTITY END_ENTITY|appos|augment	IL-7 / anti-IL-7 mAb complexes augment cytokine potency in mice through association with IgG-Fc and by competition with IL-7R .
7543134	0	IL-7R	28,33	IL-7	90,94	IL-7R	IL-7	3575	3574	Gene	Gene	cells|compound|START_ENTITY control|nmod|cells derived|nsubj|control derived|nmod|receptor receptor|compound|END_ENTITY	Cell cycle control of c-kit + IL-7R + B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium .
8879216	0	IL-7R	94,99	Thy1	101,105	IL-7R	Thy1	16197(Tax:10090)	21838(Tax:10090)	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit + IL-7R + Thy1 + lympho-hemopoietic progenitors develop .
7543134	0	IL-7R	28,33	c-kit	22,27	IL-7R	c-kit	3575	3815	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Cell cycle control of c-kit + IL-7R + B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium .
8879216	0	IL-7R	94,99	c-kit	87,92	IL-7R	c-kit	16197(Tax:10090)	16590(Tax:10090)	Gene	Gene	progenitors|compound|START_ENTITY progenitors|amod|END_ENTITY	Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit + IL-7R + Thy1 + lympho-hemopoietic progenitors develop .
20623548	0	IL-7R_alpha	67,78	CD4	62,65	IL-7R alpha	CD4	16197(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	IL-2 is positively involved in the development of colitogenic CD4 + IL-7R_alpha high memory T cells in chronic_colitis .
20623548	0	IL-7R_alpha	67,78	IL-2	0,4	IL-7R alpha	IL-2	16197(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY development|nmod|cells involved|nmod|development involved|nsubjpass|END_ENTITY	IL-2 is positively involved in the development of colitogenic CD4 + IL-7R_alpha high memory T cells in chronic_colitis .
22539288	0	IL-7Ra	15,21	CD8	53,56	IL-7Ra	CD8	16197(Tax:10090)	925	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nmod|cells cells|compound|END_ENTITY	IL-15 inhibits IL-7Ra expression by memory-phenotype CD8 T cells in the bone marrow .
23207282	0	IL-7Ra	19,25	CD8	46,49	IL-7Ra	CD8	3575	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-7 downregulates IL-7Ra expression in human CD8 T cells by two independent mechanisms .
22539288	0	IL-7Ra	15,21	IL-15	0,5	IL-7Ra	IL-15	16197(Tax:10090)	16168(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-15 inhibits IL-7Ra expression by memory-phenotype CD8 T cells in the bone marrow .
23207282	0	IL-7Ra	19,25	IL-7	0,4	IL-7Ra	IL-7	3575	3574	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	IL-7 downregulates IL-7Ra expression in human CD8 T cells by two independent mechanisms .
16860834	0	IL-7Ralpha	47,57	CD8	13,16	IL-7Ralpha	CD8	16197(Tax:10090)	925	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|cells cells|compound|END_ENTITY	HIV-specific CD8 T cells express low levels of IL-7Ralpha : implications for HIV-specific T cell memory .
10570276	0	IL-7Ralpha	10,20	IL-2	160,164	IL-7Ralpha	IL-2	16197(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	IL-2Rbeta / IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte -LRB- IEL -RRB- developmental defects of gammac - / - mice : roles for both IL-2 and IL-15 in CD8alphaalpha IEL development .
11728342	0	IL-7_receptor	4,17	Stat5	70,75	IL-7 receptor	Stat5	16197(Tax:10090)	20850(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	The IL-7_receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation .
17384281	0	IL-8	83,87	AP-1	58,62	IL-8	AP-1	3576	3725	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Role of mitogen-activated protein kinases , NF-kappaB , and AP-1 on cerulein-induced IL-8 expression in pancreatic acinar cells .
26030852	0	IL-8	18,22	ATM	0,3	IL-8	ATM	3576	472	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion .
19013427	0	IL-8	23,27	Adiponectin	0,11	IL-8	Adiponectin	3576	9370	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts .
24412633	0	IL-8	28,32	Akt	45,48	IL-8	Akt	3576	207	Gene	Gene	START_ENTITY|xcomp|activate activate|dobj|END_ENTITY	Kidney_cancer cells secrete IL-8 to activate Akt and promote migration of mesenchymal stem cells .
22015631	0	IL-8	46,50	Angiopoietin-1	0,14	IL-8	Angiopoietin-1	3576	284	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Angiopoietin-1 but not angiopoietin-2 induces IL-8 synthesis and release by human neutrophils .
25744832	0	IL-8	1,5	Bcl-2	81,86	IL-8	Bcl-2	3576	596	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	-LSB- IL-8 inhibits the apoptosis of MCF-7 human breast_cancer cells by up-regulating Bcl-2 and down-regulating caspase-3 -RSB- .
12169581	0	IL-8	21,25	Bradykinin	0,10	IL-8	Bradykinin	3576	3827	Gene	Gene	generation|compound|START_ENTITY increases|dobj|generation increases|nsubj|END_ENTITY	Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids .
15664665	0	IL-8	23,27	Bradykinin	0,10	IL-8	Bradykinin	3576	3827	Gene	Gene	production|compound|START_ENTITY alpha|nsubj|production upregulates|xcomp|alpha upregulates|nsubj|END_ENTITY	Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha .
9725250	0	IL-8	22,26	Bradykinin	0,10	IL-8	Bradykinin	3576	3827	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells : role of cyclooxygenase products .
20595617	0	IL-8	26,30	CCL20	44,49	IL-8	CCL20	3576	6364	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin .
12148887	0	IL-8	12,16	CD4	31,34	IL-8	CD4	3576	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Spontaneous IL-8 production by CD4 -LRB- + -RRB- , CD7 -LRB- + -RRB- leukemia cells in erythrodermic_S __ zary_syndrome .
22031506	0	IL-8	86,90	CD4	54,57	IL-8	CD4	3576	920	Gene	Gene	promoter|compound|START_ENTITY activity|nmod|promoter activity|compound|END_ENTITY	Native X-DING-CD4 protein secreted by HIV-1 resistant CD4 + T cells blocks activity of IL-8 promoter in human endothelial cells infected with enteric bacteria .
24692846	0	IL-8	14,18	CD4	38,41	IL-8	CD4	3576	920	Gene	Gene	Generation|nmod|START_ENTITY Generation|acl|producing producing|dobj|cells cells|compound|END_ENTITY	Generation of IL-8 and IL-9 producing CD4 T cells is affected by Th17 polarizing conditions and AHR ligands .
8576572	0	IL-8	14,18	CD4	66,69	IL-8	CD4	3576	920	Gene	Gene	Production|nmod|START_ENTITY selected|nsubj|Production selected|dobj|+ +|compound|END_ENTITY	Production of IL-8 and IL-4 by positively and negatively selected CD4 + and CD8 + human T cells following a four-step cell separation method including magnetic cell sorting -LRB- MACS -RRB- .
8604020	0	IL-8	0,4	CD4	85,88	IL-8	CD4	3576	920	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|compound|END_ENTITY	IL-8 induces T cell chemotaxis , suppresses IL-4 , and up-regulates IL-8 production by CD4 + T cells .
17586662	0	IL-8	56,60	CXCL8	61,66	IL-8	CXCL8	3576	3576	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Molecular mechanisms of thrombin-induced interleukin-8 -LRB- IL-8 / CXCL8 -RRB- expression in THP-1-derived and primary human macrophages .
22394598	0	IL-8	45,49	CXCL8	50,55	IL-8	CXCL8	3576	3576	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	ALK+ALCL s induce cutaneous , HMGB-1-dependent IL-8 / CXCL8 production by keratinocytes through NF-kB activation .
10588510	0	IL-8	52,56	CXCR1	25,30	IL-8	CXCR1	3576	3577	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Ca2 Ca2|compound|END_ENTITY	CXCR2 stimulation primes CXCR1 -LSB- Ca2 + -RSB- i responses to IL-8 in human neutrophils .
11350788	0	IL-8	0,4	CXCR1	32,37	IL-8	CXCR1	3576	3577	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways .
15252057	0	IL-8	51,55	CXCR1	68,73	IL-8	CXCR1	3576	3577	Gene	Gene	interleukin-8|dep|START_ENTITY receptor|amod|interleukin-8 receptor|amod|binding binding|nmod|END_ENTITY	Dimer_dissociation is essential for interleukin-8 -LRB- IL-8 -RRB- binding to CXCR1 receptor .
16517565	0	IL-8	73,77	CXCR1	109,114	IL-8	CXCR1	3576	3577	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of combined 17beta-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture .
17876799	0	IL-8	48,52	CXCR1	25,30	IL-8	CXCR1	3576	3577	Gene	Gene	CXCL8|compound|START_ENTITY receptor|nmod|CXCL8 studies|appos|receptor studies|nmod|END_ENTITY	Computational studies of CXCR1 , the receptor of IL-8 / CXCL8 , using molecular dynamics and electrostatics .
25081383	0	IL-8	4,8	CXCR1	9,14	IL-8	CXCR1	3576	3577	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|axis axis|compound|END_ENTITY	The IL-8 / CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic_cancer cases .
9070443	0	IL-8	0,4	CXCR1	85,90	IL-8	CXCR1	3576	3577	Gene	Gene	homodimers|compound|START_ENTITY homodimers|dep|interactions interactions|nmod|END_ENTITY	IL-8 single-chain homodimers and heterodimers : interactions with chemokine receptors CXCR1 , CXCR2 , and DARC .
9725262	0	IL-8	42,46	CXCR1	61,66	IL-8	CXCR1	3576	3577	Gene	Gene	type|compound|START_ENTITY activity|nmod|type activity|dep|END_ENTITY	Expression and functional activity of the IL-8 receptor type CXCR1 and CXCR2 on human mast cells .
10588510	0	IL-8	52,56	CXCR2	0,5	IL-8	CXCR2	3576	3579	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Ca2 Ca2|compound|END_ENTITY	CXCR2 stimulation primes CXCR1 -LSB- Ca2 + -RSB- i responses to IL-8 in human neutrophils .
24883303	0	IL-8	38,42	CXCR2	43,48	IL-8	CXCR2	3576	3579	Gene	Gene	START_ENTITY|dep|axis axis|nummod|END_ENTITY	Immunohistochemical analysis of IL-6 , IL-8 / CXCR2 axis , Tyr p-STAT-3 , and SOCS-3 in lymph nodes from patients with chronic_lymphocytic_leukemia : correlation between microvascular characteristics and prognostic significance .
25389768	0	IL-8	69,73	CYLD	0,4	IL-8	CYLD	3576	1540	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CYLD negatively regulates nontypeable Haemophilus_influenzae-induced IL-8 expression via phosphatase MKP-1-dependent inhibition of ERK .
10754330	0	IL-8	40,44	Calcitonin_gene-related_peptide	0,31	IL-8	Calcitonin gene-related peptide	3576	796	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Calcitonin_gene-related_peptide induces IL-8 synthesis in human corneal epithelial cells .
24925646	0	IL-8	68,72	CysLT2	43,49	IL-8	CysLT2	3576	57105	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	ERK/Egr -1 signaling pathway is involved in CysLT2 receptor-mediated IL-8 production in HEK293 cells .
15990791	0	IL-8	20,24	Cystatin_A	0,10	IL-8	Cystatin A	3576	1475	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Cystatin_A inhibits IL-8 production by keratinocytes stimulated with Der p_1_and_Der_f_1 : biochemical skin barrier against mite cysteine proteases .
26530812	0	IL-8	0,4	E-cadherin	16,26	IL-8	E-cadherin	3576	999	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	IL-8 suppresses E-cadherin expression in nasopharyngeal_carcinoma cells by enhancing E-cadherin promoter DNA methylation .
17012372	0	IL-8	72,76	ERK1/2	84,90	IL-8	ERK1/2	3576	5595;5594	Gene	Gene	JNK|compound|START_ENTITY JNK|appos|END_ENTITY	Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8 , IL-6 , ERK1/2 , JNK , and NF-kappaB activation in a cystic fibrosis epithelial cell line .
21266854	0	IL-8	25,29	ERb	0,3	IL-8	ERb	3576	2100	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	ERb and PEA3 co-activate IL-8 expression and promote the invasion of breast_cancer cells .
23924923	0	IL-8	68,72	Ets-1	92,97	IL-8	Ets-1	3576	2113	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric_cancer cells .
11509634	0	IL-8	19,23	Fibrinogen	0,10	IL-8	Fibrinogen	3576	2244	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Fibrinogen induces IL-8 synthesis in human neutrophils stimulated with formyl-methionyl-leucyl-phenylalanine or leukotriene_B -LRB- 4 -RRB- .
8552986	0	IL-8	124,128	GM-CSF	165,171	IL-8	GM-CSF	3576	1437	Gene	Gene	G-CSF|appos|START_ENTITY erythrocytes|dep|G-CSF Adhesion|nmod|erythrocytes END_ENTITY|nsubj|Adhesion	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
20072693	0	IL-8	31,35	HGF	20,23	IL-8	HGF	3576	3082	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
7491556	0	IL-8	66,70	ICAM-1	32,38	IL-8	ICAM-1	3576	3383	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Role of elevated plasma soluble ICAM-1 and bronchial lavage fluid IL-8 levels as markers of chronic_lung_disease in premature infants .
16258194	0	IL-8	44,48	IFN-gamma	27,36	IL-8	IFN-gamma	3576	3458	Gene	Gene	IL-17|appos|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
22707092	0	IL-8	13,17	IFN-y	26,31	IL-8	IFN-y	3576	3458	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
19773182	0	IL-8	22,26	IGF-1	54,59	IL-8	IGF-1	3576	3479	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Increased circulating IL-8 is associated with reduced IGF-1 and related to poor metabolic control in adolescents with type_1_diabetes_mellitus .
14575864	0	IL-8	17,21	IGF-I	0,5	IL-8	IGF-I	3576	3479	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase .
15259026	0	IL-8	0,4	IL-1	93,97	IL-8	IL-1	3576	3553	Gene	Gene	induces|nsubj|START_ENTITY induces|parataxis|synergism synergism|nmod|LPS LPS|nmod|production production|compound|END_ENTITY	IL-8 induces a specific transcriptional profile in human neutrophils : synergism with LPS for IL-1 production .
1532945	0	IL-8	93,97	IL-1	15,19	IL-8	IL-1	3576	3553	Gene	Gene	synthesis|compound|START_ENTITY reduces|dobj|synthesis reduces|dep|END_ENTITY	Interleukin-1 -LRB- IL-1 -RRB- receptor blockade reduces endotoxin and Borrelia_burgdorferi-stimulated IL-8 synthesis in human mononuclear cells .
1937574	0	IL-8	32,36	IL-1	0,4	IL-8	IL-1	3576	3552	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IL-1 and TNF-alpha induction of IL-8 and monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- mRNA expression in a human astrocytoma cell line .
9164965	0	IL-8	89,93	IL-1	58,62	IL-8	IL-1	3576	3552	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Thrombin induces endothelial type II activation in vitro : IL-1 and TNF-alpha-independent IL-8 secretion and E-selectin expression .
8552986	0	IL-8	124,128	IL-1-beta	99,108	IL-8	IL-1-beta	3576	3553	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|compound|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
10069878	0	IL-8	12,16	IL-10	18,23	IL-8	IL-10	3576	3586	Gene	Gene	IL-13|compound|START_ENTITY IL-13|appos|END_ENTITY	Increase in IL-8 , IL-10 , IL-13 , and RANTES mRNA levels -LRB- in situ hybridization -RRB- in the nasal mucosa after nasal allergen provocation .
15804113	0	IL-8	30,34	IL-10	36,41	IL-8	IL-10	3576	3586	Gene	Gene	IL-2|dep|START_ENTITY IL-2|dep|END_ENTITY	-LSB- Analysis of cytokines -LRB- IL-2 , IL-8 , IL-10 -RRB- in the expressed prostatic secretions of chronic_prostatitis -RSB- .
17392576	0	IL-8	195,199	IL-10	202,207	IL-8	IL-10	3576	3586	Gene	Gene	START_ENTITY|appos|IL-13 IL-13|compound|END_ENTITY	Simultaneous analysis of cytokines and co-stimulatory molecules concentrations by ELISA technique and of probabilities of measurable concentrations of interleukins IL-2 , IL-4 , IL-5 , IL-6 , CXCL8 -LRB- IL-8 -RRB- , IL-10 , IL-13 occurring in plasma of healthy blood donors .
20055787	0	IL-8	20,24	IL-10	37,42	IL-8	IL-10	3576	3586	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
23316107	0	IL-8	0,4	IL-10	6,11	IL-8	IL-10	3576	3586	Gene	Gene	TGF-b|compound|START_ENTITY TGF-b|appos|END_ENTITY	IL-8 , IL-10 , TGF-b , and GCSF levels were increased in severe persistent allergic_asthma patients with the anti-IgE treatment .
24578755	0	IL-8	39,43	IL-10	45,50	IL-8	IL-10	3576	3586	Gene	Gene	Assessment|amod|START_ENTITY END_ENTITY|nsubj|Assessment	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
26441050	0	IL-8	27,31	IL-10	33,38	IL-8	IL-10	3576	3586	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Cytokine modulation -LRB- IL-6 , IL-8 , IL-10 -RRB- by human breast milk lipids on intestinal epithelial cells -LRB- Caco-2 -RRB- .
8552986	0	IL-8	124,128	IL-10	130,135	IL-8	IL-10	3576	3586	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
9665590	0	IL-8	38,42	IL-10	0,5	IL-8	IL-10	3576	3586	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation .
15743872	0	IL-8	36,40	IL-17	30,35	IL-8	IL-17	3576	3605	Gene	Gene	axis|compound|START_ENTITY activation|dep|axis activation|nmod|END_ENTITY	Intrathecal activation of the IL-17 / IL-8 axis in opticospinal_multiple_sclerosis .
8552986	0	IL-8	124,128	IL-1RA	110,116	IL-8	IL-1RA	3576	3557	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
23908665	0	IL-8	64,68	IL-1Ra	56,62	IL-8	IL-1Ra	3576	3557	Gene	Gene	b|amod|START_ENTITY b|amod|END_ENTITY	The role of cytokines in seizures : interleukin _ -LRB- IL -RRB- -1 b , IL-1Ra , IL-8 , and IL-10 .
19805069	0	IL-8	88,92	IL-1alpha	19,28	IL-8	IL-1alpha	3576	3552	Gene	Gene	network|compound|START_ENTITY regulator|nmod|network regulator|nsubj|END_ENTITY	Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6 / IL-8 cytokine network .
21475837	0	IL-8	17,21	IL-1b	0,5	IL-8	IL-1b	3576	3553	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-1b stimulates IL-8 production , including prostaglandin_E2 receptor EP4-triggered pathways , in synoviocyte MH7A cells .
22119045	0	IL-8	22,26	IL-1b	100,105	IL-8	IL-1b	3576	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nmod|stimulation stimulation|nmod|END_ENTITY	Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1b or P. _ gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling .
22707092	0	IL-8	13,17	IL-1b	0,5	IL-8	IL-1b	3576	3553	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|compound|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
24706000	0	IL-8	18,22	IL-1b	0,5	IL-8	IL-1b	3576	3553	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	IL-1b Upregulates IL-8 Production in Human M ller Cells Through Activation of the p38 MAPK and ERK1/2 Signaling Pathways .
26817313	0	IL-8	46,50	IL-1b	39,44	IL-8	IL-1b	3576	3553	Gene	Gene	concentration|dep|START_ENTITY concentration|compound|END_ENTITY	-LSB- Evaluation of the correlation between IL-1b , IL-8 , IFN-y cytokine concentration in cervico-vaginal fluid and the risk of preterm_delivery -RSB- .
26848751	0	IL-8	62,66	IL-1b	48,53	IL-8	IL-1b	3576	3553	Gene	Gene	Expression|compound|START_ENTITY Induced|dobj|Expression Induced|nsubj|Effect Effect|nmod|- -|dep|Epigallocatechin-3-Gallate Epigallocatechin-3-Gallate|nmod|END_ENTITY	The Effect of -LRB- - -RRB- - Epigallocatechin-3-Gallate on IL-1b Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated_Ophthalmopathy .
12045890	0	IL-8	42,46	IL-1beta	12,20	IL-8	IL-1beta	3576	3553	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of IL-1beta in the regulation of IL-8 and IL-6 in human corneal epithelial cells during Pseudomonas_aeruginosa colonization .
15514971	0	IL-8	34,38	IL-1beta	0,8	IL-8	IL-1beta	3576	3553	Gene	Gene	mRNA|compound|START_ENTITY stabilization|nmod|mRNA induces|dobj|stabilization induces|nsubj|END_ENTITY	IL-1beta induces stabilization of IL-8 mRNA in malignant breast_cancer cells via the 3 ' untranslated region : Involvement of divergent RNA-binding factors HuR , KSRP and TIAR .
15939312	0	IL-8	17,21	IL-1beta	0,8	IL-8	IL-1beta	3576	3553	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids .
16489252	0	IL-8	43,47	IL-1beta	21,29	IL-8	IL-1beta	3576	3553	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
17086498	0	IL-8	57,61	IL-1beta	45,53	IL-8	IL-1beta	3576	3553	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Combined effect of 25-hydroxycholesterol and IL-1beta on IL-8 production in human colon_carcinoma cell line -LRB- Caco-2 -RRB- .
17464544	0	IL-8	54,58	IL-1beta	34,42	IL-8	IL-1beta	3576	3553	Gene	Gene	secretion|compound|START_ENTITY stimulated|dobj|secretion END_ENTITY|acl|stimulated	Hepatocyte_growth_factor enhances IL-1beta stimulated IL-8 secretion by Caco-2 epithelial cells .
17586709	0	IL-8	14,18	IL-1beta	60,68	IL-8	IL-1beta	3576	3553	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	Force-induced IL-8 from periodontal ligament cells requires IL-1beta .
18060414	0	IL-8	51,55	IL-1beta	35,43	IL-8	IL-1beta	3576	3553	Gene	Gene	levels|compound|START_ENTITY importance|appos|levels importance|nmod|END_ENTITY	The prognostic importance of serum IL-1beta , IL-6 , IL-8 and TNF-alpha levels compared to trauma scoring systems for early mortality in children with blunt_trauma .
19014534	0	IL-8	33,37	IL-1beta	0,8	IL-8	IL-1beta	3576	3553	Gene	Gene	release|amod|START_ENTITY involved|nmod|release involved|nsubj|END_ENTITY	IL-1beta differently involved in IL-8 and FGF-2 release in crystalline silica-treated lung cell co-cultures .
20194723	0	IL-8	45,49	IL-1beta	25,33	IL-8	IL-1beta	3576	3553	Gene	Gene	synthesis|compound|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Proinflammatory cytokine IL-1beta stimulates IL-8 synthesis in mast cells via a leukotriene_B4_receptor_2-linked pathway , contributing to angiogenesis .
20207110	0	IL-8	67,71	IL-1beta	27,35	IL-8	IL-1beta	3576	3553	Gene	Gene	START_ENTITY|nsubj|cytokines cytokines|appos|END_ENTITY	Proinflammatory cytokines -LRB- IL-1beta and TNF-alpha -RRB- and chemokines -LRB- IL-8 and MIP-1alpha -RRB- as markers of peri-implant tissue condition .
20483667	0	IL-8	78,82	IL-1beta	11,19	IL-8	IL-1beta	3576	3553	Gene	Gene	dependent|amod|START_ENTITY fashion|amod|dependent expression|nmod|fashion reduces|dobj|expression reduces|nsubj|blockade blockade|compound|END_ENTITY	Short-term IL-1beta blockade reduces monocyte CD11b integrin expression in an IL-8 dependent fashion in patients with type 1 diabetes .
9475356	0	IL-8	27,31	IL-1beta	35,43	IL-8	IL-1beta	3576	3553	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of IL-8 by IL-1beta and TNFalpha_in_hyaline_membrane_disease .
9558101	0	IL-8	104,108	IL-1beta	20,28	IL-8	IL-1beta	3576	3553	Gene	Gene	release|compound|START_ENTITY effects|nmod|release END_ENTITY|dep|effects	Lymphocytes produce IL-1beta in response to Fcgamma receptor cross-linking : effects on parenchymal cell IL-8 release .
16489252	0	IL-8	43,47	IL-2	31,35	IL-8	IL-2	3576	3558	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
17222831	0	IL-8	167,171	IL-2	138,142	IL-8	IL-2	3576	3558	Gene	Gene	Interleukin|acl|START_ENTITY Interleukin|amod|END_ENTITY	Interleukin -LRB- IL -RRB- -12 receptor beta1 codon 378 G homozygote and allele , but not IL-1 -LRB- beta-511 promoter , 3953 exon 5 , receptor antagonist -RRB- , IL-2 114 , IL-4-590 intron 3 , IL-8 3 ' - UTR 2767 , and IL-18 105 , are associated with higher susceptibility to leiomyoma .
8144938	0	IL-8	13,17	IL-2	88,92	IL-8	IL-2	3576	3558	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression neutrophils|nsubj|Induction neutrophils|nmod|END_ENTITY	Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2 .
8360487	0	IL-8	43,47	IL-2	0,4	IL-8	IL-2	3576	3558	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-2 up-regulates but IFN-gamma suppresses IL-8 expression in human monocytes .
8397255	0	IL-8	47,51	IL-2	55,59	IL-8	IL-2	3576	3558	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|immunotherapy immunotherapy|compound|END_ENTITY	Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1_receptor_antagonist and soluble tumor necrosis factor receptor -LRB- p75 -RRB- chimera .
7871561	0	IL-8	80,84	IL-3	62,66	IL-8	IL-3	3576	3562	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
10372996	0	IL-8	52,56	IL-4	0,4	IL-8	IL-4	3576	3565	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	IL-4 potentiates IL-1beta - and TNF-alpha-stimulated IL-8 and MCP-1 protein production in human retinal pigment epithelial cells .
10565568	0	IL-8	69,73	IL-4	0,4	IL-8	IL-4	3576	3565	Gene	Gene	release|dobj|START_ENTITY stimulate|xcomp|release stimulate|nsubj|END_ENTITY	IL-4 and IL-13 stimulate human bronchial epithelial cells to release IL-8 .
10725748	0	IL-8	24,28	IL-4	42,46	IL-8	IL-4	3576	3565	Gene	Gene	receptors|amod|START_ENTITY Induction|nmod|receptors Induction|nmod|END_ENTITY	Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes .
1383379	0	IL-8	15,19	IL-4	81,85	IL-8	IL-4	3576	3565	Gene	Gene	Interleukin_8|appos|START_ENTITY inhibits|nsubj|Interleukin_8 inhibits|dobj|production production|acl|induced induced|nmod|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- selectively inhibits immunoglobulin_E production induced by IL-4 in human B cells .
16929824	0	IL-8	55,59	IL-4	37,41	IL-8	IL-4	3576	3565	Gene	Gene	tissues|amod|START_ENTITY -RSB-|nsubj|tissues -RSB-|advcl|-LSB- -LSB-|dobj|concentration concentration|nmod|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
2200823	0	IL-8	32,36	IL-4	0,4	IL-8	IL-4	3576	3565	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits the expression of IL-8 from stimulated human monocytes .
22185464	0	IL-8	13,17	IL-4	7,11	IL-8	IL-4	3576	3565	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Plasma IL-4 , IL-8 , IL-12 , interferon-y and CRP levels in pregnant women with preeclampsia , and their relation with severity of disease and fetal birth weight .
24578755	0	IL-8	39,43	IL-4	27,31	IL-8	IL-4	3576	3565	Gene	Gene	Assessment|amod|START_ENTITY Assessment|nmod|END_ENTITY	Assessment of Interleukins IL-4 , IL-6 , IL-8 , IL-10 in Acute Urticaria .
7864891	0	IL-8	15,19	IL-4	49,53	IL-8	IL-4	3576	3565	Gene	Gene	Interleukin_8|appos|START_ENTITY inhibits|nsubj|Interleukin_8 inhibits|dobj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
7864891	0	IL-8	161,165	IL-4	49,53	IL-8	IL-4	3576	3565	Gene	Gene	inhibited|nsubj|START_ENTITY kinase|acl:relcl|inhibited involve|dobj|kinase mechanisms|acl:relcl|involve inhibits|nmod|mechanisms inhibits|dobj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
7871561	0	IL-8	80,84	IL-4	68,72	IL-8	IL-4	3576	3565	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
10843719	0	IL-8	125,129	IL-6	119,123	IL-8	IL-6	3576	3569	Gene	Gene	IL-15|dep|START_ENTITY IL-15|compound|END_ENTITY	Increased CD40 expression on muscle cells of polymyositis and dermatomyositis : role of CD40-CD40_ligand interaction in IL-6 , IL-8 , IL-15 , and monocyte_chemoattractant_protein-1 production .
12382118	0	IL-8	48,52	IL-6	14,18	IL-8	IL-6	3576	3569	Gene	Gene	production|compound|START_ENTITY production|nmod|production production|compound|END_ENTITY	PKC-dependent IL-6 production and inhibition of IL-8 production by PKC activation in normal human skin fibroblasts under extremely high hydrostatic pressure .
12938511	0	IL-8	24,28	IL-6	30,34	IL-8	IL-6	3576	3569	Gene	Gene	IL-2|compound|START_ENTITY IL-2|dep|END_ENTITY	Effect of Sinomenine on IL-8 , IL-6 , IL-2 produced by peripheral blood mononuclear cells .
1382099	4	IL-8	756,760	IL-6	750,754	IL-8	IL-6	3576	3569	Gene	Gene	G-CSF|dep|START_ENTITY G-CSF|compound|END_ENTITY	On exposure of human astrocytes to IL-1_beta , high levels of IL-6 , IL-8 , M-CSF , G-CSF , and GM-CSF mRNAs were detected ; moreover , active secretion of all the above cytokines was demonstrated .
15072962	0	IL-8	95,99	IL-6	106,110	IL-8	IL-6	3576	3569	Gene	Gene	influenced|nsubjpass|START_ENTITY influenced|nmod|END_ENTITY	Cytokine gene expression in human skeletal muscle during concentric contraction : evidence that IL-8 , like IL-6 , is influenced by glycogen availability .
15298427	0	IL-8	119,123	IL-6	113,117	IL-8	IL-6	3576	3569	Gene	Gene	IL-10|amod|START_ENTITY IL-10|amod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
16258194	0	IL-8	44,48	IL-6	38,42	IL-8	IL-6	3576	3569	Gene	Gene	IL-17|appos|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16929824	0	IL-8	55,59	IL-6	49,53	IL-8	IL-6	3576	3569	Gene	Gene	tissues|amod|START_ENTITY tissues|dep|END_ENTITY	-LSB- The concentration and expression of IL-4 , IL-5 , IL-6 , IL-8 in human nasal_polyps tissues -RSB- .
17012372	0	IL-8	72,76	IL-6	78,82	IL-8	IL-6	3576	3569	Gene	Gene	JNK|compound|START_ENTITY JNK|appos|END_ENTITY	Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8 , IL-6 , ERK1/2 , JNK , and NF-kappaB activation in a cystic fibrosis epithelial cell line .
18799095	0	IL-8	31,35	IL-6	10,14	IL-8	IL-6	3576	3569	Gene	Gene	Cytokine|dep|START_ENTITY Cytokine|dep|END_ENTITY	Cytokine -LRB- IL-6 -RRB- and chemokine -LRB- IL-8 -RRB- gene polymorphisms among rheumatoid_arthritis patients in Taiwan .
19304283	0	IL-8	36,40	IL-6	13,17	IL-8	IL-6	3576	3569	Gene	Gene	secretion|compound|START_ENTITY Induction|nmod|secretion Induction|nmod|END_ENTITY	Induction of IL-6 and inhibition of IL-8 secretion in the human airway cell line Calu-3 by urban particulate matter collected with a modified method of PM sampling .
19805069	0	IL-8	88,92	IL-6	83,87	IL-8	IL-6	3576	3569	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6 / IL-8 cytokine network .
20055787	0	IL-8	20,24	IL-6	14,18	IL-8	IL-6	3576	3569	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|compound|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
20072693	0	IL-8	31,35	IL-6	25,29	IL-8	IL-6	3576	3569	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
21122279	0	IL-8	115,119	IL-6	109,113	IL-8	IL-6	3576	3569	Gene	Gene	GM-CSF|dep|START_ENTITY GM-CSF|dep|END_ENTITY	Montelukast reduces eosinophilic inflammation by inhibiting both epithelial cell cytokine secretion -LRB- GM-CSF , IL-6 , IL-8 -RRB- and eosinophil survival .
22707092	0	IL-8	13,17	IL-6	7,11	IL-8	IL-6	3576	3569	Gene	Gene	TNF-a|appos|START_ENTITY TNF-a|appos|END_ENTITY	IL-1b , IL-6 , IL-8 , IL-10 , IFN-y , TNF-a and its relationship with lipid parameters in patients with major_depression .
22832157	0	IL-8	21,25	IL-6	15,19	IL-8	IL-6	3576	3569	Gene	Gene	CRP|appos|START_ENTITY CRP|compound|END_ENTITY	Elevated serum IL-6 , IL-8 , MCP-1 , CRP , and IFN-y levels in 10 - to 11-year-old boys with increased BMI .
23156730	0	IL-8	30,34	IL-6	24,28	IL-8	IL-6	3576	3569	Gene	Gene	expression|compound|START_ENTITY -RSB-|nsubj|expression -RSB-|advcl|-LSB- -LSB-|dobj|effect effect|nmod|Hsp72 Hsp72|nmod|END_ENTITY	-LSB- The effect of Hsp72 on IL-6 , IL-8 expression and activation of NF-kappaB in synoviocytes of rheumatoid_arthritis -RSB- .
24402554	0	IL-8	29,33	IL-6	23,27	IL-8	IL-6	3576	3569	Gene	Gene	IL-4|dep|START_ENTITY IL-4|dep|END_ENTITY	Cytokine levels -LRB- IL-4 , IL-6 , IL-8 and TGFb -RRB- as potential biomarkers of systemic_inflammatory_response in trauma patients .
25358651	0	IL-8	6,10	IL-6	0,4	IL-8	IL-6	3576	3569	Gene	Gene	MMP-9|amod|START_ENTITY END_ENTITY|amod|MMP-9	IL-6 , IL-8 , MMP-2 , MMP-9 are overexpressed in Fanconi_anemia cells through a NF-kB/TNF-a dependent mechanism .
26994898	0	IL-8	46,50	IL-6	40,44	IL-8	IL-6	3576	3569	Gene	Gene	MCP-1|appos|START_ENTITY MCP-1|compound|END_ENTITY	Effects of Shock Waves on Expression of IL-6 , IL-8 , MCP-1 , and TNF-a Expression by Human Periodontal Ligament Fibroblasts : An In Vitro Study .
7683506	0	IL-8	50,54	IL-6	43,47	IL-8	IL-6	3576	3569	Gene	Gene	interleukin_6|amod|START_ENTITY interleukin_6|appos|END_ENTITY	Elevation of amniotic fluid interleukin_6 -LRB- IL-6 -RRB- , IL-8 and granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in term and preterm parturition .
7871561	0	IL-8	80,84	IL-6	74,78	IL-8	IL-6	3576	3569	Gene	Gene	-2|amod|START_ENTITY -2|amod|END_ENTITY	The value of posttransplant monitoring of interleukin -LRB- IL -RRB- -2 , IL-3 , IL-4 , IL-6 , IL-8 , and soluble CD23 in the plasma of renal allograft recipients .
8552986	0	IL-8	124,128	IL-6	118,122	IL-8	IL-6	3576	3569	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
9773833	0	IL-8	135,139	IL-6	129,133	IL-8	IL-6	3576	3569	Gene	Gene	beta|amod|START_ENTITY beta|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
1517567	0	IL-8	36,40	IL-7	0,4	IL-8	IL-7	3576	3574	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	IL-7 up-regulates the expression of IL-8 from resting and stimulated human blood monocytes .
10565569	0	IL-8	122,126	IL-8	127,131	IL-8	IL-8	3576	3576	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|system system|compound|END_ENTITY	Effects of the neuropeptides substance_P , calcitonin_gene-related_peptide and alpha-melanocyte-stimulating_hormone on the IL-8 / IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts .
10565569	0	IL-8	127,131	IL-8	122,126	IL-8	IL-8	3576	3576	Gene	Gene	system|compound|START_ENTITY Effects|dep|system Effects|nmod|END_ENTITY	Effects of the neuropeptides substance_P , calcitonin_gene-related_peptide and alpha-melanocyte-stimulating_hormone on the IL-8 / IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts .
24172227	0	IL-8	55,59	IL-8	87,91	IL-8	IL-8	3576	3576	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors .
24172227	0	IL-8	87,91	IL-8	55,59	IL-8	IL-8	3576	3576	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors .
7517209	0	IL-8	105,109	IL-8	164,168	IL-8	IL-8	3576	3576	Gene	Gene	expression|appos|START_ENTITY expression|nmod|protein protein|compound|END_ENTITY	Cytokine gene expression in B-cell_chronic_lymphocytic_leukemia : evidence of constitutive interleukin-8 -LRB- IL-8 -RRB- mRNA expression and secretion of biologically active IL-8 protein .
7517209	0	IL-8	164,168	IL-8	105,109	IL-8	IL-8	3576	3576	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein expression|appos|END_ENTITY	Cytokine gene expression in B-cell_chronic_lymphocytic_leukemia : evidence of constitutive interleukin-8 -LRB- IL-8 -RRB- mRNA expression and secretion of biologically active IL-8 protein .
9840119	0	IL-8	38,42	IL-8	6,10	IL-8	IL-8	3576	3576	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum IL-8 levels and localization of IL-8 in liver from patients with chronic_viral_hepatitis .
9840119	0	IL-8	6,10	IL-8	38,42	IL-8	IL-8	3576	3576	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Serum IL-8 levels and localization of IL-8 in liver from patients with chronic_viral_hepatitis .
25840641	0	IL-8	13,17	IL-9	0,4	IL-9	IL-9	3578	3578	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes : A plausible mechanism of IL-9R in atopic_dermatitis .
25840641	0	IL-8	13,17	IL-9	0,4	IL-9	IL-9	3578	3578	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes : A plausible mechanism of IL-9R in atopic_dermatitis .
9326248	0	IL-8	31,35	Interleukin-15	0,14	IL-8	Interleukin-15	3576	3600	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- induces IL-8 and monocyte_chemotactic_protein_1 production in human monocytes .
15208668	0	IL-8	29,33	Interleukin-1beta	0,17	IL-8	Interleukin-1beta	3576	3553	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric_carcinoma cells .
18607537	0	IL-8	0,4	JNK	45,48	IL-8	JNK	3576	5599	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	IL-8 and p53 are inversely regulated through JNK , p38 and NF-kappaB_p65 in HepG2 cells during an inflammatory response .
10528206	0	IL-8	25,29	L-selectin	43,53	IL-8	L-selectin	3576	6402	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Neutrophil dysfunctions , IL-8 , and soluble L-selectin plasma levels in rapidly progressive versus adult and localized juvenile_periodontitis : variations according to disease severity and microbial flora .
21532911	0	IL-8	71,75	LFA-1	40,45	IL-8	LFA-1	3576	3689	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling and Dynamics of Activation of LFA-1 and Mac-1 by Immobilized IL-8 .
19307752	0	IL-8	39,43	LL-37	0,5	IL-8	LL-37	3576	820	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	LL-37 inhibits serum_amyloid_A-induced IL-8 production in human neutrophils .
18501560	0	IL-8	15,19	Leptin	0,6	IL-8	Leptin	3576	3952	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin induces IL-8 expression via leptin receptor , IRS-1 , PI3K , Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts .
1937574	0	IL-8	32,36	MCAF	85,89	IL-8	MCAF	3576	6347	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	IL-1 and TNF-alpha induction of IL-8 and monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- mRNA expression in a human astrocytoma cell line .
11835523	0	IL-8	80,84	MCP-1	54,59	IL-8	MCP-1	3576	6347	Gene	Gene	monocyte_chemoattractant_protein-1|appos|START_ENTITY monocyte_chemoattractant_protein-1|appos|END_ENTITY	Urinary levels of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and interleukin-8 -LRB- IL-8 -RRB- , and renal_injuries in patients with type 2 diabetic_nephropathy .
22832157	0	IL-8	21,25	MCP-1	27,32	IL-8	MCP-1	3576	6347	Gene	Gene	CRP|appos|START_ENTITY CRP|appos|END_ENTITY	Elevated serum IL-6 , IL-8 , MCP-1 , CRP , and IFN-y levels in 10 - to 11-year-old boys with increased BMI .
25704572	0	IL-8	36,40	MCP-1	12,17	IL-8	MCP-1	3576	6347	Gene	Gene	appraisal|compound|START_ENTITY END_ENTITY|nmod|appraisal	Addition of MCP-1 and MIP-3b to the IL-8 appraisal in peritoneal fluid enhances the probability of identifying women with endometriosis .
25785032	0	IL-8	53,57	MCP-1	59,64	IL-8	MCP-1	3576	6347	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Ghrelin inhibits AngII - induced expression of TNF-a , IL-8 , MCP-1 in human umbilical vein endothelial cells .
9132652	0	IL-8	14,18	MCP-1	8,13	IL-8	MCP-1	3576	6347	Gene	Gene	ratio|compound|START_ENTITY ratio|dep|END_ENTITY	Inverse MCP-1 / IL-8 ratio in effluents of CAPD patients with peritonitis and in isolated cultured human peritoneal macrophages .
20872800	0	IL-8	81,85	Macrophage_migration_inhibitory_factor	0,38	IL-8	Macrophage migration inhibitory factor	3576	4282	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal_carcinoma .
1711550	0	IL-8	75,79	NAP-1	69,74	IL-8	NAP-1	3576	3576	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Upper keratinocytes of psoriatic skin_lesions express high levels of NAP-1 / IL-8 mRNA in situ .
2405845	0	IL-8	6,10	NAP-1	0,5	IL-8	NAP-1	3576	3576	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|appos|induces	NAP-1 / IL-8 induces up-regulation of CR1 receptors in human neutrophil leukocytes .
8334226	0	IL-8	48,52	NAP-1	53,58	IL-8	NAP-1	3576	3576	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Cell type specific expression of members of the IL-8 / NAP-1 gene family .
12164866	0	IL-8	114,118	NF-kappaB	77,86	IL-8	NF-kappaB	3576	4790	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|dependent dependent|advmod|END_ENTITY	Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-kappaB dependent up-regulation of IL-8 and MCP-1 .
12960242	0	IL-8	46,50	NF-kappaB	120,129	IL-8	NF-kappaB	3576	4790	Gene	Gene	produce|dobj|START_ENTITY produce|nmod|generation generation|nmod|activation activation|nmod|END_ENTITY	Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB .
15280021	0	IL-8	52,56	NF-kappaB	101,110	IL-8	NF-kappaB	3576	4790	Gene	Gene	production|nmod|START_ENTITY stimulates|nmod|production stimulates|nmod|mechanism mechanism|nmod|END_ENTITY	Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB .
15521010	0	IL-8	74,78	NF-kappaB	48,57	IL-8	NF-kappaB	3576	4790	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|dobj|secretion	hPepT1 transports muramyl_dipeptide , activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells .
16076765	0	IL-8	36,40	NF-kappaB	60,69	IL-8	NF-kappaB	3576	4790	Gene	Gene	production|compound|START_ENTITY induce|dobj|production induce|nmod|activation activation|amod|END_ENTITY	Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells .
16128401	0	IL-8	50,54	NF-kappaB	174,183	IL-8	NF-kappaB	3576	4790	Gene	Gene	cytokines|amod|START_ENTITY Expression|nmod|cytokines Expression|dep|regulation regulation|nmod|END_ENTITY	Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia_rickettsii_infection : regulation by nuclear transcription factor NF-kappaB .
16871430	0	IL-8	97,101	NF-kappaB	59,68	IL-8	NF-kappaB	3576	4790	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|amod|END_ENTITY	Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic_adenocarcinoma cells .
17471497	0	IL-8	30,34	NF-kappaB	98,107	IL-8	NF-kappaB	3576	4790	Gene	Gene	regulation|nmod|START_ENTITY independent|nsubj|regulation independent|nmod|END_ENTITY	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2 - and p38 kinase-dependent activation of AP-1 .
17581194	0	IL-8	27,31	NF-kappaB	59,68	IL-8	NF-kappaB	3576	4790	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB , but not RANTES , IL-6 , eotaxin or TARC expression in nasal epithelium .
18258920	0	IL-8	81,85	NF-kappaB	46,55	IL-8	NF-kappaB	3576	4790	Gene	Gene	transcription|nmod|START_ENTITY inhibit|dobj|transcription inhibit|advmod|END_ENTITY	Transcription factor oligodeoxynucleotides to NF-kappaB inhibit transcription of IL-8 in bronchial cells .
19837667	0	IL-8	37,41	NF-kappaB	131,140	IL-8	NF-kappaB	3576	4790	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nmod|synergy synergy|amod|END_ENTITY	Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate_cancer cells through suppressing EGR-1 / NF-kappaB synergy .
22043704	0	IL-8	43,47	NF-kappaB	12,21	IL-8	NF-kappaB	3576	4790	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of NF-kappaB on the expression of IL-8 in human bronchial epithelial cells induced by cigarette smoke condensates -RSB- .
22772035	0	IL-8	133,137	NF-kappaB	116,125	IL-8	NF-kappaB	3576	4790	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
22772035	0	IL-8	133,137	NF-kappaB	37,46	IL-8	NF-kappaB	3576	4790	Gene	Gene	gene|compound|START_ENTITY NF-kappaB|nmod|gene promoter|amod|NF-kappaB recruitment|nmod|promoter Effects|dep|recruitment Effects|nmod|molecules molecules|acl|targeting targeting|dobj|factors factors|amod|END_ENTITY	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
22772035	0	IL-8	177,181	NF-kappaB	116,125	IL-8	NF-kappaB	3576	4790	Gene	Gene	gene|compound|START_ENTITY recruitment|nmod|gene recruitment|nmod|promoter promoter|amod|END_ENTITY	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
22772035	0	IL-8	177,181	NF-kappaB	37,46	IL-8	NF-kappaB	3576	4790	Gene	Gene	gene|compound|START_ENTITY recruitment|nmod|gene Effects|dep|recruitment Effects|nmod|molecules molecules|acl|targeting targeting|dobj|factors factors|amod|END_ENTITY	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
23156730	0	IL-8	30,34	NF-kappaB	64,73	IL-8	NF-kappaB	3576	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- The effect of Hsp72 on IL-6 , IL-8 expression and activation of NF-kappaB in synoviocytes of rheumatoid_arthritis -RSB- .
9665590	0	IL-8	38,42	NF-kappaB	60,69	IL-8	NF-kappaB	3576	4790	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nmod|inhibition inhibition|nmod|activation activation|amod|END_ENTITY	IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation .
27013197	0	IL-8	25,29	NFAT1	0,5	IL-8	NFAT1	3576	4773	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	NFAT1 directly regulates IL-8 and MMP-3 to promote melanoma_tumor growth and metastasis .
21670316	0	IL-8	18,22	NTPDase1	0,8	IL-8	NTPDase1	3576	953	Gene	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	NTPDase1 controls IL-8 production by human neutrophils .
15070680	0	IL-8	52,56	PAR-2	103,108	IL-8	PAR-2	3576	2150	Gene	Gene	expression|compound|START_ENTITY up-regulation|nmod|expression mediated|nsubjpass|up-regulation mediated|nmod|END_ENTITY	Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration .
17581194	0	IL-8	27,31	PAR-2	0,5	IL-8	PAR-2	3576	2150	Gene	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|activation activation|compound|END_ENTITY	PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB , but not RANTES , IL-6 , eotaxin or TARC expression in nasal epithelium .
19889021	0	IL-8	85,89	PAR-2	95,100	IL-8	PAR-2	3576	2150	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation .
19286927	0	IL-8	55,59	PP2A	19,23	IL-8	PP2A	3576	5524	Gene	Gene	production|compound|START_ENTITY regulation|nmod|production regulation|compound|END_ENTITY	Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells .
15568616	0	IL-8	20,24	Prolactin	0,9	IL-8	Prolactin	3576	5617	Gene	Gene	production|compound|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Prolactin modulates IL-8 production induced by porins or LPS through different signaling mechanisms .
8738804	0	IL-8	74,78	Proteinase_3	0,12	IL-8	Proteinase 3	3576	5657	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Proteinase_3 , the major autoantigen of Wegener 's _ granulomatosis , enhances IL-8 production by endothelial cells in vitro .
19064995	0	IL-8	173,177	RelA	121,125	IL-8	RelA	3576	5970	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Pseudomonas_aeruginosa induces interleukin-8 -LRB- IL-8 -RRB- gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding _ protein_beta to the IL-8 promoter .
19064995	0	IL-8	46,50	RelA	121,125	IL-8	RelA	3576	5970	Gene	Gene	interleukin-8|dep|START_ENTITY expression|amod|interleukin-8 induces|dobj|expression induces|nmod|recruitment recruitment|nmod|END_ENTITY	Pseudomonas_aeruginosa induces interleukin-8 -LRB- IL-8 -RRB- gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding _ protein_beta to the IL-8 promoter .
19135383	0	IL-8	92,96	RelA	203,207	IL-8	RelA	3576	5970	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression infrared|nmod|regulation infrared|nmod|IL-1beta-stimulated IL-1beta-stimulated|acl:relcl|involves involves|dobj|phosphorylation phosphorylation|nmod|subunit subunit|compound|END_ENTITY	Effects of linear polarized infrared light irradiation on the transcriptional regulation of IL-8 expression in IL-1beta-stimulated human rheumatoid synoviocytes involves phosphorylation of the NF-kappaB RelA subunit .
8207232	0	IL-8	46,50	RelA	75,79	IL-8	RelA	3576	5970	Gene	Gene	gene|compound|START_ENTITY activation|nmod|gene transcriptional|dobj|activation transcriptional|nmod|p65 p65|appos|END_ENTITY	Synergistic transcriptional activation of the IL-8 gene by NF-kappa_B p65 -LRB- RelA -RRB- and NF-IL-6 .
26321412	0	IL-8	34,38	S1PR1	68,73	IL-8	S1PR1	3576	1901	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Sphingosine_1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8 / SVneo cells .
11306951	0	IL-8	14,18	SDF-1	0,5	IL-8	SDF-1	3576	6387	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	SDF-1 induces IL-8 production and transendothelial migration of human cord blood-derived mast cells .
24660467	0	IL-8	36,40	SP-C1	55,60	IL-8	SP-C1	3576	28972	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	8-hydroxycudraxanthone_G suppresses IL-8 production in SP-C1 tongue_cancer cells .
11053288	0	IL-8	38,42	Substance_P	0,11	IL-8	Substance P	3576	6863	Gene	Gene	synthesis|compound|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Substance_P differentially stimulates IL-8 synthesis in human corneal epithelial cells .
10893219	0	IL-8	21,25	TGF-beta1	0,9	IL-8	TGF-beta1	3576	7040	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	TGF-beta1 stimulates IL-8 release , COX-2 expression , and PGE -LRB- 2 -RRB- release in human airway_smooth_muscle cells .
16204411	0	IL-8	18,22	TGF-beta1	0,9	IL-8	TGF-beta1	3576	7040	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	TGF-beta1 induces IL-8 and MCP-1 through a connective_tissue_growth_factor-independent pathway .
18435575	0	IL-8	40,44	TGF-beta1	19,28	IL-8	TGF-beta1	20309(Tax:10090)	21803(Tax:10090)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Osteoblast-derived TGF-beta1 stimulates IL-8 release through AP-1 and NF-kappaB in human cancer cells .
9844046	0	IL-8	48,52	TGF-beta1	160,169	IL-8	TGF-beta1	3576	7040	Gene	Gene	expression|compound|START_ENTITY cells|dep|expression cells|dep|role role|nmod|transforming_growth_factor-beta_1 transforming_growth_factor-beta_1|appos|END_ENTITY	Human intestinal epithelial cells down-regulate IL-8 expression in human intestinal microvascular endothelial cells ; role of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- .
8552986	0	IL-8	124,128	TGF_beta	137,145	IL-8	TGF beta	3576	7040	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
10799807	0	IL-8	15,19	THP-1	81,86	IL-8	THP-1	3576	2736	Gene	Gene	production|compound|START_ENTITY Enhancement|nmod|production Enhancement|amod|END_ENTITY	Enhancement of IL-8 production from human monocytic and granulocytic cell lines , THP-1 and HL-60 , stimulated with Malassezia furfur .
17761353	0	IL-8	24,28	THP-1	138,143	IL-8	THP-1	20309(Tax:10090)	2736	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nmod|activation activation|nmod|factors factors|nmod|cells cells|compound|END_ENTITY	Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-kappaB and AP-1 in PMA-differentiated THP-1 cells .
19938227	0	IL-8	57,61	THP-1	88,93	IL-8	THP-1	3576	2736	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells .
21969073	0	IL-8	24,28	THP-1	48,53	IL-8	THP-1	3576	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin .
9588080	0	IL-8	15,19	THP-1	27,32	IL-8	THP-1	3576	2736	Gene	Gene	START_ENTITY|nmod|line line|amod|monocyte monocyte|amod|END_ENTITY	-LSB- Production of IL-8 by the THP-1 monocyte cell line is regulated differently by cyclosporin and retinoic_acid -RSB- .
26088451	0	IL-8	20,24	THP1	43,47	IL-8	THP1	3576	2736	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|compound|END_ENTITY	Cancer cell-derived IL-8 induces monocytic THP1 cells to secrete IL-8 via the mitogen-activated protein kinase pathway .
18494145	0	IL-8	45,49	THp-1	88,93	IL-8	THp-1	3576	2736	Gene	Gene	release|nmod|START_ENTITY MAPK|nmod|release Role|nmod|MAPK induced|nsubj|Role induced|nmod|allergen allergen|nmod|cells cells|amod|END_ENTITY	Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells .
12561375	0	IL-8	57,61	TLR-4	27,32	IL-8	TLR-4	3576	7099	Gene	Gene	transcription|compound|START_ENTITY END_ENTITY|nmod|transcription	-LSB- Assessment of the role of TLR-4 in shear-stress-induced IL-8 gene transcription activation in vascular endothelial cells by gene mutation and gene transfection technology -RSB- .
22762377	0	IL-8	28,32	TLR3	63,67	IL-8	TLR3	3576	7098	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes .
10843739	0	IL-8	14,18	TNF	87,90	IL-8	TNF	3576	7124	Gene	Gene	gene|compound|START_ENTITY Expression|nmod|gene Expression|dep|regulation regulation|nmod|END_ENTITY	Expression of IL-8 gene in human monocytes and lymphocytes : differential regulation by TNF and IL-1 .
11500086	0	IL-8	21,25	TNF	0,3	IL-8	TNF	3576	7124	Gene	Gene	transactivation|compound|START_ENTITY promote|dobj|transactivation promote|nsubj|END_ENTITY	TNF and CD95 promote IL-8 gene transactivation via independent elements in colon_carcinoma cells .
12960727	0	IL-8	17,21	TNF	23,26	IL-8	TNF	3576	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Cytokines -LRB- IL-6 , IL-8 , TNF -RRB- : early and reliable predictors of severe acute_pancreatitis .
20827577	0	IL-8	37,41	TNF-a	0,5	IL-8	TNF-a	3576	7124	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	TNF-a induces vectorial secretion of IL-8 in Caco-2 cells .
24455739	0	IL-8	30,34	TNF-a	61,66	IL-8	TNF-a	3576	7124	Gene	Gene	production|compound|START_ENTITY reduce|dobj|production reduce|nmod|challenge challenge|amod|END_ENTITY	Lactobacilli reduce chemokine IL-8 production in response to TNF-a and Salmonella challenge of Caco-2 cells .
25785032	0	IL-8	53,57	TNF-a	46,51	IL-8	TNF-a	3576	7124	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Ghrelin inhibits AngII - induced expression of TNF-a , IL-8 , MCP-1 in human umbilical vein endothelial cells .
11332087	0	IL-8	25,29	TNF-alpha	12,21	IL-8	TNF-alpha	3576	7124	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of TNF-alpha on IL-8 mRNA expression in endothelial cells -RSB- .
11597930	0	IL-8	27,31	TNF-alpha	84,93	IL-8	TNF-alpha	3576	7124	Gene	Gene	transcription|nmod|START_ENTITY regulated|nsubjpass|transcription regulated|nmod|phospholipids phospholipids|amod|END_ENTITY	Increased transcription of IL-8 in endothelial cells is differentially regulated by TNF-alpha and oxidized phospholipids .
12204776	0	IL-8	113,117	TNF-alpha	56,65	IL-8	TNF-alpha	3576	7124	Gene	Gene	secretion|amod|START_ENTITY blocking|dobj|secretion stimulated|advcl|blocking END_ENTITY|acl|stimulated	17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion , but not its transcription .
15081568	0	IL-8	68,72	TNF-alpha	14,23	IL-8	TNF-alpha	3576	7124	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of TNF-alpha , PMA , and LPS on plasma and cell-associated IL-8 in human leukocytes .
15162444	0	IL-8	91,95	TNF-alpha	23,32	IL-8	TNF-alpha	3576	7124	Gene	Gene	release|compound|START_ENTITY mediated|nmod|release mediated|nsubjpass|effect effect|nmod|END_ENTITY	The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa_B-dependent IL-8 release .
15217317	0	IL-8	63,67	TNF-alpha	97,106	IL-8	TNF-alpha	3576	7124	Gene	Gene	response|compound|START_ENTITY response|acl:relcl|unlinked unlinked|nmod|responses responses|amod|END_ENTITY	Leprosy patients with lepromatous_disease have an up-regulated IL-8 response that is unlinked to TNF-alpha responses .
15225374	0	IL-8	60,64	TNF-alpha	21,30	IL-8	TNF-alpha	3576	7124	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression inhibition|nmod|production production|amod|END_ENTITY	Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ_67657 , a p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- inhibitor .
15273081	0	IL-8	12,16	TNF-alpha	39,48	IL-8	TNF-alpha	3576	7124	Gene	Gene	responses|amod|START_ENTITY Exaggerated|dobj|responses Exaggerated|nmod|END_ENTITY	Exaggerated IL-8 and IL-6 responses to TNF-alpha by parainfluenza_virus_type_4-infected NCI-H292 cells .
15298427	0	IL-8	119,123	TNF-alpha	102,111	IL-8	TNF-alpha	3576	7124	Gene	Gene	IL-10|amod|START_ENTITY reaction|amod|IL-10 reaction|dep|effects effects|nmod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
16258194	0	IL-8	44,48	TNF-alpha	16,25	IL-8	TNF-alpha	3576	7124	Gene	Gene	IL-17|appos|START_ENTITY IL-17|compound|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16489252	0	IL-8	43,47	TNF-alpha	49,58	IL-8	TNF-alpha	3576	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
16949835	0	IL-8	36,40	TNF-alpha	55,64	IL-8	TNF-alpha	3576	7124	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha - and dexamethasone-stimulated human periodontal ligament cells .
17306937	0	IL-8	66,70	TNF-alpha	43,52	IL-8	TNF-alpha	3576	7124	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	The role of sphingosine_1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells .
17546909	0	IL-8	43,47	TNF-alpha	49,58	IL-8	TNF-alpha	3576	7124	Gene	Gene	IL-2R|dep|START_ENTITY IL-2R|dep|END_ENTITY	Platelet storage time and cytokine -LRB- IL-2R , IL-8 , TNF-alpha -RRB- levels .
19874800	0	IL-8	0,4	TNF-alpha	97,106	IL-8	TNF-alpha	3576	7124	Gene	Gene	production|compound|START_ENTITY enhanced|nsubj|production enhanced|ccomp|combined combined|nmod|END_ENTITY	IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-alpha .
20055787	0	IL-8	20,24	TNF-alpha	26,35	IL-8	TNF-alpha	3576	7124	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
22561123	0	IL-8	104,108	TNF-alpha	72,81	IL-8	TNF-alpha	3576	7124	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|amod|END_ENTITY	Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells .
24994458	0	IL-8	23,27	TNF-alpha	29,38	IL-8	TNF-alpha	3576	7124	Gene	Gene	IL-6|appos|START_ENTITY END_ENTITY|nsubj|IL-6	Increased plasma IL-6 , IL-8 , TNF-alpha , and G-CSF in Japanese narcolepsy .
12585121	0	IL-8	42,46	TNF_alpha	91,100	IL-8	TNF alpha	3576	7124	Gene	Gene	production|compound|START_ENTITY production|acl|induced induced|nmod|END_ENTITY	-LSB- Inhibitory effects of isorhapotigenin on IL-8 production and mRNA expression induced with TNF_alpha in normal human synovial cells -RSB- .
8552986	0	IL-8	124,128	TNF_alpha	147,156	IL-8	TNF alpha	3576	7124	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8574751	0	IL-8	9,13	TNF_alpha	96,105	IL-8	TNF alpha	3576	7124	Gene	Gene	production|compound|START_ENTITY associated|nsubjpass|production associated|nmod|secretion secretion|nmod|END_ENTITY	Elevated IL-8 production by trauma patients ' monocytes is associated with elevated secretion of TNF_alpha .
9427069	0	IL-8	0,4	TNF_alpha	31,40	IL-8	TNF alpha	100009129(Tax:9986)	100009088(Tax:9986)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	IL-8 is involved in homologous TNF_alpha - , but not in IL-1_beta-induced neutrophil infiltration in rabbits .
18056395	0	IL-8	132,136	TNF_receptor-associated_factor_6	25,57	IL-8	TNF receptor-associated factor 6	3576	222344	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Caspase-4 interacts with TNF_receptor-associated_factor_6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 -LRB- macrophage-inflammatory protein-1 -RRB- .
22525504	0	IL-8	14,18	TNFa	1,5	IL-8	TNFa	3576	7124	Gene	Gene	production|compound|START_ENTITY induced|dobj|production END_ENTITY|acl|induced	-LSB- TNFa induced IL-8 production through p38 MAPK - NF-kB pathway in human hepatocellular_carcinoma cells -RSB- .
8683138	0	IL-8	61,65	Transforming_growth_factor-beta_1	0,33	IL-8	Transforming growth factor-beta 1	3576	7040	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium .
19229069	0	IL-8	6,10	VCAM-1	40,46	IL-8	VCAM-1	3576	7412	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow .
21631990	0	IL-8	0,4	VCAM-1	13,19	IL-8	VCAM-1	3576	7412	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|secretion secretion|compound|END_ENTITY	IL-8 reduces VCAM-1 secretion of smooth muscle cells by increasing p-ERK expression when 3-D co-cultured with vascular endothelial cells .
19597830	0	IL-8	46,50	VEGF	30,34	IL-8	VEGF	3576	7422	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Gingko_biloba extract reduces VEGF and CXCL-8 / IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate .
20072693	0	IL-8	31,35	VEGF	14,18	IL-8	VEGF	3576	7422	Gene	Gene	MMP-9|appos|START_ENTITY MMP-9|compound|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
20156197	0	IL-8	69,73	VEGF	10,14	IL-8	VEGF	280828(Tax:9913)	281572(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of VEGF -LRB- vascular_endothelial_growth_factor -RRB- on expression of IL-8 -LRB- interleukin-8 -RRB- , IL-1beta and their receptors in bovine theca cells .
23495770	0	IL-8	40,44	VEGF	82,86	IL-8	VEGF	3576	7422	Gene	Gene	START_ENTITY|appos|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Regulatory T cells , interleukin _ -LRB- IL -RRB- -6 , IL-8 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , CXCL10 , CXCL11 , epidermal_growth_factor -LRB- EGF -RRB- and hepatocyte_growth_factor -LRB- HGF -RRB- as surrogate markers of host immunity in patients with renal_cell_carcinoma .
12729795	0	IL-8	30,34	Von_Willebrand_factor	0,21	IL-8	Von Willebrand factor	3576	7450	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	Von_Willebrand_factor targets IL-8 to Weibel-Palade_bodies in an endothelial cell line .
23197259	0	IL-8	15,19	YKL-40	0,6	IL-8	YKL-40	3576	1116	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	YKL-40 induces IL-8 expression from bronchial epithelium via MAPK -LRB- JNK and ERK -RRB- and NF-kB pathways , causing bronchial smooth muscle proliferation and migration .
16039610	0	IL-8	29,33	adiponectin	14,25	IL-8	adiponectin	3576	9370	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells .
9472473	0	IL-8	37,41	albumin	21,28	IL-8	albumin	3576	213	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Glycated human serum albumin induces IL-8 and MCP-1 gene expression in human corneal keratocytes .
26305549	0	IL-8	88,92	androgen_receptor	93,110	IL-8	androgen receptor	3576	367	Gene	Gene	/|amod|START_ENTITY END_ENTITY|amod|/	Tumor microenvironment B cells increase bladder_cancer metastasis via modulation of the IL-8 / androgen_receptor -LRB- AR -RRB- / MMPs signals .
19346317	0	IL-8	11,15	arylsulfatase_B	62,77	IL-8	arylsulfatase B	3576	411	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase_B silencing due to sequestration with chondroitin-4-sulfate .
15197351	0	IL-8	61,65	endostatin	36,46	IL-8	endostatin	3576	80781	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic_cancer .
9363923	0	IL-8	14,18	eosinophil-derived_neurotoxin	34,63	IL-8	eosinophil-derived neurotoxin	3576	6036	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of IL-8 and release of eosinophil-derived_neurotoxin by normal peripheral blood eosinophils .
19112101	0	IL-8	43,47	epidermal_growth_factor-receptor	81,113	IL-8	epidermal growth factor-receptor	3576	1956	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal_growth_factor-receptor in human bronchial epithelial cells .
12161534	0	IL-8	39,43	fas_ligand	14,24	IL-8	fas ligand	3576	356	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of fas_ligand expression by IL-8 in human endometrium .
16498082	0	IL-8	90,94	granulocyte_colony-stimulating_factor	51,88	PAR2	granulocyte colony-stimulating factor	2150	1440	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Proteinase-activated_receptor2 agonists upregulate granulocyte_colony-stimulating_factor , IL-8 , and VCAM-1 expression in human bronchial fibroblasts .
9773833	0	IL-8	135,139	granulocyte_colony-stimulating_factor	37,74	IL-8	granulocyte colony-stimulating factor	3576	1440	Gene	Gene	beta|amod|START_ENTITY expression|dep|beta expression|nmod|_ _|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
18400834	0	IL-8	74,78	hypoxia-inducible_factor-1alpha	8,39	IL-8	hypoxia-inducible factor-1alpha	3576	3091	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of hypoxia-inducible_factor-1alpha in hypoxia-induced expressions of IL-8 , MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes .
21765616	0	IL-8	137,141	interleukin-15	65,79	IL-8	interleukin-15	3576	3600	Gene	Gene	crosstalk|nmod|START_ENTITY END_ENTITY|dep|crosstalk	Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin_D -LRB- 3 -RRB- : a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic_rhinitis .
10086655	0	IL-8	125,129	interleukin-8	10,23	IL-8	interleukin-8	3576	3576	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role END_ENTITY|dep|evidence	Increased interleukin-8 -LRB- IL-8 -RRB- in rectal dialysate from patients with ulcerative_colitis : evidence for a biological role for IL-8 in inflammation of the colon .
10853906	0	IL-8	25,29	interleukin-8	10,23	IL-8	interleukin-8	3576	3576	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Increased interleukin-8 -LRB- IL-8 -RRB- expression is related to aseptic_loosening_of_total_hip_replacement .
12561382	0	IL-8	33,37	interleukin-8	18,31	IL-8	interleukin-8	3576	3576	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The study on the interleukin-8 -LRB- IL-8 -RRB- -RSB- .
12781210	0	IL-8	62,66	interleukin-8	47,60	IL-8	interleukin-8	3576	3576	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of interleukin-1alpha -LRB- IL-1alpha -RRB- and interleukin-8 -LRB- IL-8 -RRB- expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization .
16739069	0	IL-8	41,45	interleukin-8	26,39	IL-8	interleukin-8	3576	3576	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Green tea extract induces interleukin-8 -LRB- IL-8 -RRB- mRNA and protein expression but specifically inhibits IL-8 secretion in caco-2 cells .
16819095	0	IL-8	69,73	interleukin-8	54,67	IL-8	interleukin-8	3576	3576	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ozone enhances diesel exhaust particles -LRB- DEP -RRB- - induced interleukin-8 -LRB- IL-8 -RRB- gene expression in human airway epithelial cells through activation of nuclear factors - kappaB -LRB- NF-kappaB -RRB- and IL-6 -LRB- NF-IL6 -RRB- .
19095436	0	IL-8	39,43	interleukin-8	24,37	IL-8	interleukin-8	3576	3576	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The predictive value of interleukin-8 -LRB- IL-8 -RRB- in hospitalised patients with fever and chemotherapy-induced neutropenia .
1932367	0	IL-8	28,32	interleukin-8	13,26	IL-8	interleukin-8	3576	3576	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Elevation of interleukin-8 -LRB- IL-8 -RRB- levels in joint fluids of patients with rheumatoid_arthritis and the induction by IL-8 of leukocyte infiltration and synovitis in rabbit_joints .
21530580	0	IL-8	72,76	interleukin-8	57,70	IL-8	interleukin-8	100036815(Tax:8355)	100036815(Tax:8355)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Molecular cloning , expression and functional analysis of interleukin-8 -LRB- IL-8 -RRB- in South African clawed_frog -LRB- Xenopus_laevis -RRB- .
22244449	0	IL-8	47,51	interleukin-8	32,45	IL-8	interleukin-8	3576	3576	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	An immunohistochemical study of interleukin-8 -LRB- IL-8 -RRB- in breast_cancer .
22293942	0	IL-8	118,122	interleukin-8	103,116	IL-8	interleukin-8	3576	3576	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Association of glutathione_S-transferase 1-1 polymorphisms -LRB- A140D and E208K -RRB- with the expression of interleukin-8 -LRB- IL-8 -RRB- , transforming_growth_factor_beta -LRB- TGF-b -RRB- , and apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- in humans chronically exposed to arsenic in drinking water .
24337575	0	IL-8	127,131	interleukin-8	112,125	IL-8	interleukin-8	3576	3576	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Proteasome inhibition increases recruitment of IkB_kinase_b -LRB- IKKb -RRB- , S536P-p65 , and transcription factor EGR1 to interleukin-8 -LRB- IL-8 -RRB- promoter , resulting in increased IL-8 production in ovarian_cancer cells .
7517209	0	IL-8	105,109	interleukin-8	90,103	IL-8	interleukin-8	3576	3576	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cytokine gene expression in B-cell_chronic_lymphocytic_leukemia : evidence of constitutive interleukin-8 -LRB- IL-8 -RRB- mRNA expression and secretion of biologically active IL-8 protein .
7518426	0	IL-8	33,37	interleukin-8	18,31	IL-8	interleukin-8	100009129(Tax:9986)	3576	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The N terminus of interleukin-8 -LRB- IL-8 -RRB- receptor confers high affinity binding to human IL-8 .
7964163	0	IL-8	40,44	interleukin-8	25,38	IL-8	interleukin-8	3576	3576	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Essential involvement of interleukin-8 -LRB- IL-8 -RRB- in acute inflammation .
8246610	0	IL-8	42,46	interleukin-8	27,40	IL-8	interleukin-8	3576	3576	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Constitutive production of interleukin-8 -LRB- IL-8 -RRB- by normal and malignant human B-cells and other cell types .
8454590	0	IL-8	52,56	interleukin-8	37,50	IL-8	interleukin-8	3576	3576	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Modification of sulfhydryl groups of interleukin-8 -LRB- IL-8 -RRB- receptor impairs binding of IL-8 and IL-8-mediated chemotactic response of human polymorphonuclear neutrophils .
9125224	0	IL-8	68,72	interleukin-8	53,66	IL-8	interleukin-8	20309(Tax:10090)	20309(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Redox regulation of lipopolysaccharide -LRB- LPS -RRB- - induced interleukin-8 -LRB- IL-8 -RRB- gene expression mediated by NF kappa B and AP-1 in human astrocytoma U373 cells .
18501560	0	IL-8	15,19	leptin	35,41	IL-8	leptin	3576	3952	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cascade cascade|amod|END_ENTITY	Leptin induces IL-8 expression via leptin receptor , IRS-1 , PI3K , Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts .
26449498	0	IL-8	14,18	miR-93	58,64	IL-8	miR-93	3576	407051	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of IL-8 gene expression in gliomas by microRNA miR-93 .
26986724	0	IL-8	43,47	miR-93-5p	9,18	IL-8	miR-93-5p	3576	100126325	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells .
19596978	0	IL-8	0,4	mucin	15,20	IL-8	mucin	3576	100508689	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells .
19121622	0	IL-8	34,38	neuraminidase	10,23	IL-8	neuraminidase	3576	4758	Gene	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Bacterial neuraminidase increases IL-8 production in lung epithelial cells via NF-kappaB-dependent pathway .
1505106	0	IL-8	53,57	neutrophil_activating_peptide-1	14,45	IL-8	neutrophil activating peptide-1	3576	3576	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of neutrophil_activating_peptide-1 -LRB- NAP-1 / IL-8 -RRB- by blood and synovial fluid mononuclear cells from patients with arthritis .
2156928	0	IL-8	68,72	neutrophil_chemotactic_factor	38,67	IL-8	neutrophil chemotactic factor	3576	4689	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Cytokine-induced gene expression of a neutrophil_chemotactic_factor / IL-8 in human hepatocytes .
12667212	0	IL-8	114,118	p38_mitogen-activated_protein_kinase	4,40	IL-8	p38 mitogen-activated protein kinase	3576	1432	Gene	Gene	promoter|compound|START_ENTITY effect|nmod|promoter expression|nmod|effect regulates|dobj|expression regulates|nsubj|END_ENTITY	The p38_mitogen-activated_protein_kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells .
12667212	0	IL-8	77,81	p38_mitogen-activated_protein_kinase	4,40	IL-8	p38 mitogen-activated protein kinase	3576	1432	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The p38_mitogen-activated_protein_kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells .
15225374	0	IL-8	60,64	p38_mitogen-activated_protein_kinase	139,175	IL-8	p38 mitogen-activated protein kinase	3576	1432	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression inhibition|nmod|RWJ_67657 RWJ_67657|appos|inhibitor inhibitor|amod|END_ENTITY	Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ_67657 , a p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- inhibitor .
16192891	0	IL-8	28,32	p38_mitogen-activated_protein_kinase	51,87	IL-8	p38 mitogen-activated protein kinase	3576	1432	Gene	Gene	secretion|compound|START_ENTITY enhances|dobj|secretion enhances|nmod|species species|amod|END_ENTITY	Interleukin-1alpha enhances IL-8 secretion through p38_mitogen-activated_protein_kinase and reactive oxygen species signaling in human pancreatic_cancer cells .
18277946	0	IL-8	99,103	p38_mitogen-activated_protein_kinase	4,40	IL-8	p38 mitogen-activated protein kinase	3576	1432	Gene	Gene	production|compound|START_ENTITY role|nmod|production plays|dobj|role plays|nsubj|pathway pathway|amod|END_ENTITY	The p38_mitogen-activated_protein_kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion .
26011935	0	IL-8	36,40	phosphodiesterase_4B	12,32	IL-8	phosphodiesterase 4B	3576	5142	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	IL-8	36,40	phosphodiesterase_4B	12,32	IL-8	phosphodiesterase 4B	3576	5142	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	IL-8	36,40	phosphodiesterase_4B	99,119	IL-8	phosphodiesterase 4B	3576	5142	Gene	Gene	role|nmod|START_ENTITY role|parataxis|evaluated evaluated|nmod|inhibitor inhibitor|amod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	IL-8	36,40	phosphodiesterase_4B	99,119	IL-8	phosphodiesterase 4B	3576	5142	Gene	Gene	role|nmod|START_ENTITY role|parataxis|evaluated evaluated|nmod|inhibitor inhibitor|amod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
8913284	0	IL-8	116,120	stem_cell_factor	145,161	IL-8	stem cell factor	20309(Tax:10090)	17311(Tax:10090)	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nmod|END_ENTITY	Improved survival of lethally irradiated recipient mice transplanted with circulating progenitor cells mobilized by IL-8 after pretreatment with stem_cell_factor .
10565569	0	IL-8	122,126	substance_P	29,40	IL-8	substance P	3576	6863	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the neuropeptides substance_P , calcitonin_gene-related_peptide and alpha-melanocyte-stimulating_hormone on the IL-8 / IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts .
10565569	0	IL-8	127,131	substance_P	29,40	IL-8	substance P	3576	6863	Gene	Gene	system|compound|START_ENTITY Effects|dep|system Effects|nmod|END_ENTITY	Effects of the neuropeptides substance_P , calcitonin_gene-related_peptide and alpha-melanocyte-stimulating_hormone on the IL-8 / IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts .
19472082	0	IL-8	79,83	toll-like_receptor_3	8,28	IL-8	toll-like receptor 3	3576	7098	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of toll-like_receptor_3 , RIG-I , and MDA5 in the expression of mesothelial IL-8 induced by viral RNA .
9344494	0	IL-8	40,44	transforming_growth_factor-beta	69,100	IL-8	transforming growth factor-beta	3576	7040	Gene	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	Cocaine inhibits human endothelial cell IL-8 production : the role of transforming_growth_factor-beta .
22293942	0	IL-8	118,122	transforming_growth_factor_beta	125,156	IL-8	transforming growth factor beta	3576	7040	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Association of glutathione_S-transferase 1-1 polymorphisms -LRB- A140D and E208K -RRB- with the expression of interleukin-8 -LRB- IL-8 -RRB- , transforming_growth_factor_beta -LRB- TGF-b -RRB- , and apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- in humans chronically exposed to arsenic in drinking water .
9773833	0	IL-8	135,139	tumor_necrosis_factor-alpha	76,103	IL-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	beta|amod|START_ENTITY expression|dep|beta expression|nmod|_ _|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
18657446	0	IL-8R	74,79	interleukin-8_receptor	50,72	IL-8R	interleukin-8 receptor	100135914(Tax:8022)	100135914(Tax:8022)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- interleukin-8_receptor -LRB- IL-8R -RRB- gene transcription in response to viral_hemorrhagic_septicemia virus -LRB- VHSV -RRB- , DNA vaccination and chemokines .
10088599	0	IL-8RA	14,20	CXCR1	22,27	IL-8RA	CXCR1	3577	3577	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Regulation of IL-8RA -LRB- CXCR1 -RRB- expression in polymorphonuclear leukocytes by hypoxia/reoxygenation .
8598483	0	IL-8_and_granulocyte-macrophage_colony-stimulating_factor	49,106	Oncostatin_M	0,12	IL-8 and granulocyte-macrophage colony-stimulating factor	Oncostatin M	3576;1437	5008	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Oncostatin_M inhibits IL-1-induced expression of IL-8_and_granulocyte-macrophage_colony-stimulating_factor by synovial and lung fibroblasts .
12952969	0	IL-8_and_tumor_necrosis_factor-alpha	82,118	Interleukin-6	0,13	IL-8 and tumor necrosis factor-alpha	Interleukin-6	3576;7124	3569	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- induces insulin resistance in 3T3-L1 adipocytes and is , like IL-8_and_tumor_necrosis_factor-alpha , overexpressed in human fat cells from insulin-resistant subjects .
20169197	0	IL-9	0,4	CCL11	13,18	IL-9	CCL11	3578	6356	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	IL-9 induces CCL11 expression via STAT3 signalling in human airway_smooth_muscle cells .
20020328	0	IL-9	0,4	CD4	43,46	IL-9	CD4	3578	920	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	IL-9 : basic biology , signaling pathways in CD4 + T cells and implications for autoimmunity .
20090929	0	IL-9	40,44	CD4	36,39	IL-9	CD4	3578	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Human CD4 memory T cells can become CD4 + IL-9 + T cells .
20090929	0	IL-9	40,44	CD4	6,9	IL-9	CD4	3578	920	Gene	Gene	cells|compound|START_ENTITY become|xcomp|cells become|nsubj|cells cells|compound|END_ENTITY	Human CD4 memory T cells can become CD4 + IL-9 + T cells .
20540113	0	IL-9	69,73	CD4	94,97	IL-9	CD4	16198(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY trigger|dobj|production trigger|nmod|T T|compound|END_ENTITY	TGF-b interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4 -LRB- + -RRB- T cells .
26322481	0	IL-9	40,44	CD4	59,62	IL-9	CD4	3578	920	Gene	Gene	production|compound|START_ENTITY production|nmod|T T|compound|END_ENTITY	The DNA-binding inhibitor Id3 regulates IL-9 production in CD4 -LRB- + -RRB- T cells .
27094152	0	IL-9	0,4	CD4	73,76	IL-9	CD4	3578	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|dep|CD8 CD8|compound|END_ENTITY	IL-9 promotes the survival and function of human melanoma - infiltrating CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- double-positive T cells .
7930607	0	IL-9	0,4	CD4	25,28	IL-9	CD4	16198(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	IL-9 production of naive CD4 + T cells depends on IL-2 , is synergistically enhanced by a combination of TGF-beta and IL-4 , and is inhibited by IFN-gamma .
16650898	0	IL-9	58,62	GATA-1	106,112	IL-9	GATA-1	16198(Tax:10090)	14460(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1 .
22904310	0	IL-9	36,40	Gcn5	0,4	IL-9	Gcn5	3578	2648	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells .
23119059	0	IL-9	43,47	IFN-b	0,5	IL-9	IFN-b	16198(Tax:10090)	15977(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IFN-b inhibits the increased expression of IL-9 during experimental autoimmune uveoretinitis .
10657629	0	IL-9	152,156	IL-10	129,134	IL-9	IL-10	3578	3586	Gene	Gene	cytokine|nmod|START_ENTITY cytokine|xcomp|related related|nmod|END_ENTITY	Cloning and characterization of IL-10-related_T_cell-derived_inducible_factor -LRB- IL-TIF -RRB- , a novel cytokine structurally related to IL-10 and inducible by IL-9 .
10820228	0	IL-9	61,65	IL-10	93,98	IL-9	IL-10	16198(Tax:10090)	16153(Tax:10090)	Gene	Gene	producers|nmod|START_ENTITY producers|dep|function function|nmod|END_ENTITY	Murine bone marrow-derived mast cells as potent producers of IL-9 : costimulatory function of IL-10 and kit_ligand in the presence of IL-1 .
18997793	0	IL-9	85,89	IL-10	91,96	IL-9	IL-10	16198(Tax:10090)	16153(Tax:10090)	Gene	Gene	Foxp3|compound|START_ENTITY Foxp3|compound|END_ENTITY	IL-4 inhibits TGF-beta-induced Foxp3 + T cells and , together with TGF-beta , generates IL-9 + IL-10 + Foxp3 -LRB- - -RRB- effector T cells .
10984364	0	IL-9	0,4	IL-1beta	52,60	IL-9	IL-1beta	3578	3553	Gene	Gene	expression|compound|START_ENTITY expression|dep|regulation regulation|nmod|END_ENTITY	IL-9 expression by human eosinophils : regulation by IL-1beta and TNF-alpha .
20154671	0	IL-9	14,18	IL-25	33,38	IL-9	IL-25	3578	64806	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|signaling signaling|compound|END_ENTITY	Regulation of IL-9 expression by IL-25 signaling .
7691943	0	IL-9	13,17	IL-3	37,41	IL-9	IL-3	16198(Tax:10090)	16187(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases .
21765905	0	IL-9	14,18	IL-33	0,5	IL-9	IL-33	3578	90865	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-33 induces IL-9 production in human CD4 + T cells and basophils .
25840641	0	IL-9	0,4	IL-8	13,17	IL-9	IL-9	3578	3578	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes : A plausible mechanism of IL-9R in atopic_dermatitis .
25840641	0	IL-9	0,4	IL-8	13,17	IL-9	IL-9	3578	3578	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes : A plausible mechanism of IL-9R in atopic_dermatitis .
20169197	0	IL-9	0,4	STAT3	34,39	IL-9	STAT3	3578	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	IL-9 induces CCL11 expression via STAT3 signalling in human airway_smooth_muscle cells .
11937570	0	IL-9	0,4	TGF-beta	109,117	IL-9	TGF-beta	3578	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta .
20498357	0	IL-9	17,21	TGF-beta	0,8	IL-9	TGF-beta	3578	7040	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	TGF-beta induces IL-9 production from human Th17 cells .
18339896	0	IL-9	17,21	Tax	37,40	IL-9	Tax	3578	1491938(Tax:11908)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult_T-cell_leukemia cells by a paracrine mechanism .
1433974	0	IL-9	80,84	interleukin_9	65,78	IL-9	interleukin 9	16198(Tax:10090)	16198(Tax:10090)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Function , molecular structure and gene expression regulation of interleukin_9 -LRB- IL-9 -RRB- -RSB- .
8666384	0	IL-9_receptor	4,17	IL9R	24,28	IL-9 receptor	IL9R	3581	3581	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The IL-9_receptor gene -LRB- IL9R -RRB- : genomic structure , chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes , and identification of IL9R pseudogenes at 9qter , 10pter , 16pter , and 18pter .
3010001	0	IL1	20,23	Interleukin-1	0,13	IL1	Interleukin-1	3552	3552	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin-1 gene -LRB- IL1 -RRB- assigned to long arm of human chromosome 2 .
18844578	0	IL10	54,58	AUF1	0,4	IL10	AUF1	3586	3184	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nummod|END_ENTITY	AUF1 isoform-specific regulation of anti-inflammatory IL10 expression in monocytes .
21135123	0	IL10	62,66	AUF1	20,24	IL10	AUF1	3586	3184	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNA-binding_protein AUF1 regulates lipopolysaccharide-induced IL10 expression by activating IkappaB kinase complex in monocytes .
10580805	0	IL10	16,20	Interleukin-10	0,14	IL10	Interleukin-10	3586	3586	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Interleukin-10 -LRB- IL10 -RRB- promoter polymorphisms and multiple_sclerosis .
24971461	0	IL10	109,113	TLR4	54,58	IL10	TLR4	3586	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
25409741	0	IL10	42,46	TNF	48,51	IL10	TNF	3586	7124	Gene	Gene	IL6|dep|START_ENTITY IL6|dep|END_ENTITY	A study of genes encoding cytokines -LRB- IL6 , IL10 , TNF -RRB- , cytokine receptors -LRB- IL6R , IL6ST -RRB- , and glucocorticoid_receptor -LRB- NR3C1 -RRB- and susceptibility to bronchopulmonary_dysplasia .
24747960	0	IL10	122,126	histone_deacetylase_6	19,40	IL10	histone deacetylase 6	3586	10013	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Divergent roles of histone_deacetylase_6 -LRB- HDAC6 -RRB- and histone_deacetylase_11 -LRB- HDAC11 -RRB- on the transcriptional regulation of IL10 in antigen presenting cells .
23898109	0	IL10	31,35	interleukin-10	15,29	IL10	interleukin-10	3586	3586	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Association of interleukin-10 -LRB- IL10 -RRB- promoter genotypes with nasopharyngeal_carcinoma risk in Taiwan .
25627396	0	IL10A	0,5	IL-10	43,48	IL10A	IL-10	3586	3586	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon .
25627396	0	IL10A	0,5	IL-10	43,48	IL10A	IL-10	3586	3586	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon .
1386338	0	IL11	72,76	interleukin-11	51,65	IL11	interleukin-11	3589	3589	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic sequence and chromosomal location of human interleukin-11 gene -LRB- IL11 -RRB- .
8786120	0	IL11RA	46,52	interleukin-11_receptor_alpha	10,39	IL11RA	interleukin-11 receptor alpha	3590	3590	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human interleukin-11_receptor_alpha gene -LRB- IL11RA -RRB- : genomic organization and chromosome mapping .
18367309	0	IL12B	25,30	Interleukin-12_p40	0,18	IL12B	Interleukin-12 p40	3593	3593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin-12_p40 gene -LRB- IL12B -RRB- polymorphisms and the risk of cervical_cancer in Korean women .
12424623	0	IL12B	65,70	interleukin-12_p40	45,63	IL12B	interleukin-12 p40	3593	3593	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A promoter polymorphism in the gene encoding interleukin-12_p40 -LRB- IL12B -RRB- is associated with mortality from cerebral_malaria and with reduced nitric_oxide production .
15993716	0	IL12RB1	52,59	interleukin_12_receptor	27,50	IL12RB1	interleukin 12 receptor	3594	3594	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin 12 -LRB- IL12B -RRB- and interleukin_12_receptor -LRB- IL12RB1 -RRB- gene polymorphisms in rheumatoid_arthritis .
11340333	0	IL13	4,8	CD4	0,3	IL13	CD4	3596	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	CD4 + IL13 + T lymphocytes at birth and the development of wheezing and/or asthma during the 1st year of life .
11555670	0	IL13	110,114	IL13Ralpha2	74,85	IL13	IL13Ralpha2	3596	3598	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	Expression of interleukin_13 receptor in glioma_and_renal_cell_carcinoma : IL13Ralpha2 as a decoy receptor for IL13 .
26831416	0	IL13	98,102	IL4	92,95	IL13	IL4	3596	3565	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
8798406	0	IL13	96,100	IL4	77,80	IL13	IL4	3596	3565	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	Receptor for interleukin _ -LRB- IL -RRB- _ 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells .
26831416	0	IL13	98,102	interleukin_4	77,90	IL13	interleukin 4	3596	3565	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
11555670	0	IL13Ralpha2	74,85	IL13	110,114	IL13Ralpha2	IL13	3598	3596	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	Expression of interleukin_13 receptor in glioma_and_renal_cell_carcinoma : IL13Ralpha2 as a decoy receptor for IL13 .
25412359	0	IL15Ra	82,88	IL-15	76,81	IL15Ra	IL-15	3601	3600	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	NK cell activation in human hantavirus_infection explained by virus-induced IL-15 / IL15Ra expression .
26367076	0	IL17	31,35	IL17A	0,5	IL17	IL17A	3605	3605	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	IL17A gene polymorphism , serum IL17 and total IgE in Egyptian population with chronic HCV and hepatocellular_carcinoma .
19277040	0	IL17A	58,63	CD4	54,57	IL17A	CD4	3605	920	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	The effects of trastuzumab on the CD4 + CD25 + FoxP3 + and CD4 + IL17A + T-cell axis in patients with breast_cancer .
26367076	0	IL17A	0,5	IL17	31,35	IL17A	IL17	3605	3605	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	IL17A gene polymorphism , serum IL17 and total IgE in Egyptian population with chronic HCV and hepatocellular_carcinoma .
19210369	0	IL17A	38,43	interleukin_17A	21,36	IL17A	interleukin 17A	3605	3605	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The polymorphisms of interleukin_17A -LRB- IL17A -RRB- gene and its association with pediatric asthma in Taiwanese population .
23220496	0	IL17RA	77,83	Interleukin_17_receptor_A	50,75	IL17RA	Interleukin 17 receptor A	23765	23765	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of single nucleotide polymorphisms on Interleukin_17_receptor_A -LRB- IL17RA -RRB- gene with aspirin hypersensitivity in asthmatics .
22070932	0	IL17RB	17,23	Smurf2	0,6	IL17RB	Smurf2	55540	64750	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2 .
19229765	0	IL18	21,25	Interleukin-18	0,14	IL18	Interleukin-18	3606	3606	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin-18 gene -LRB- IL18 -RRB- promoter polymorphisms in patients with rheumatoid_arthritis .
23557801	0	IL18	16,20	Interleukin_18	0,14	IL18	Interleukin 18	3606	3606	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Interleukin_18 -LRB- IL18 -RRB- gene promoter polymorphisms are associated with type_1_diabetes_mellitus in Brazilian patients .
25955681	0	IL1A	68,72	miRNA-122	38,47	IL1A	miRNA-122	3552	406906	Gene	Gene	Site|nmod|START_ENTITY Site|amod|END_ENTITY	An Insertion/Deletion Polymorphism at miRNA-122 Binding Site in the IL1A Is Associated with a Reduced Risk of Cervical_Squamous_Cell_Carcinoma .
19016479	0	IL1B	52,56	IL-1beta	37,45	IL1B	IL-1beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Tagging SNP association study of the IL-1beta gene -LRB- IL1B -RRB- and childhood-onset_mood_disorders .
25422961	0	IL1B	21,25	Interleukin_1B	0,14	IL1B	Interleukin 1B	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin_1B gene -LRB- IL1B -RRB- variation and internalizing symptoms in maltreated preschoolers .
16435917	0	IL1B	19,23	Interleukin_1beta	0,17	IL1B	Interleukin 1beta	16176(Tax:10090)	16176(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Interleukin_1beta -LRB- IL1B -RRB- signaling is a critical component of radiation-induced skin fibrosis .
24839897	0	IL1B	45,49	interleukin-1b	24,38	IL1B	interleukin-1b	3553	3553	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between the interleukin-1b Gene -LRB- IL1B -RRB- C-511T polymorphism and the risk of diabetic_nephropathy in type 2 diabetes : a candidate-gene association study .
19043479	0	IL1B	76,80	interleukin_1_beta	56,74	IL1B	interleukin 1 beta	3553	3553	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Association of -31 T > C and -511 _ C > T polymorphisms in the interleukin_1_beta -LRB- IL1B -RRB- promoter in Korean keratoconus patients .
20044070	0	IL1B	24,28	interleukin_1_beta	4,22	IL1B	interleukin 1 beta	3553	3553	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The interleukin_1_beta -LRB- IL1B -RRB- gene is associated with failure to achieve remission and impaired emotion processing in major_depression .
7799967	0	IL1B	61,65	prointerleukin_1_beta	33,54	IL1B	prointerleukin 1 beta	3553	3553	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Monocyte expression of the human prointerleukin_1_beta gene -LRB- IL1B -RRB- is dependent on promoter sequences which bind the hematopoietic transcription factor Spi-1 / PU .1 .
11197691	0	IL1R1	96,101	interleukin-1_receptor_type_1	65,94	IL1R1	interleukin-1 receptor type 1	3554	3554	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of new polymorphisms in the 5 ' UTR of the human interleukin-1_receptor_type_1 -LRB- IL1R1 -RRB- gene : linkage to type 1 diabetes and correlation to IL-1RI plasma level .
20714405	0	IL1RAPL1	60,68	JNK	9,12	IL1RAPL1	JNK	331461(Tax:10090)	26419(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1 , a protein required for development of cognitive functions .
21926414	0	IL1RAPL1	45,53	PTP	104,107	IL1RAPL1	PTP	11141	10076	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The X-linked intellectual_disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTP and RhoGAP2 .
23785489	0	IL1RAPL1	0,8	RhoA	151,155	IL1RAPL1	RhoA	11141	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	IL1RAPL1 associated with mental_retardation and autism regulates the formation and stabilization of glutamatergic synapses of cortical neurons through RhoA signaling pathway .
15365221	0	IL1RN	71,76	IL-1_receptor_antagonist	40,64	IL1RN	IL-1 receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Replication test for association of the IL-1_receptor_antagonist gene , IL1RN , with attention-deficit/hyperactivity _ disorder .
8432529	0	IL1RN	45,50	interleukin-1_receptor_antagonist	10,43	IL1RN	interleukin-1 receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human interleukin-1_receptor_antagonist -LRB- IL1RN -RRB- gene is located in the chromosome 2q14 region .
24952603	0	IL1RN	50,55	interleukin_1_receptor_antagonist	15,48	IL1RN	interleukin 1 receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of interleukin_1_receptor_antagonist -LRB- IL1RN -RRB- gene polymorphism with recurrent pregnancy_loss risk in the North Indian Population and a meta-analysis .
18423886	0	IL1Ra	55,60	interleukin_1_receptor_antagonist	20,53	IL1Ra	interleukin 1 receptor antagonist	3557	3557	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism of the interleukin_1_receptor_antagonist -LRB- IL1Ra -RRB- gene and placental_abruption .
15745939	0	IL1_alpha	36,45	VEGF	15,19	IL1 alpha	VEGF	3552	7422	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Correlation of VEGF production with IL1_alpha and IL6 secretion by human pituitary_adenoma_cells .
26204512	0	IL1b	44,48	S100B	0,5	IL1b	S100B	16176(Tax:10090)	20203(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	S100B Up-Regulates Macrophage Production of IL1b and CCL22 and Influences Severity of Retinal Inflammation .
26204512	0	IL1b	44,48	S100B	0,5	IL1b	S100B	16176(Tax:10090)	20203(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	S100B Up-Regulates Macrophage Production of IL1b and CCL22 and Influences Severity of Retinal Inflammation .
22114704	0	IL1b	35,39	TLR2/1	19,25	IL1b	TLR2/1	16176(Tax:10090)	24088;21897	Gene	Gene	expression|amod|START_ENTITY mediated|dobj|expression mediated|nsubj|END_ENTITY	Nod2 downregulates TLR2/1 mediated IL1b gene expression in mouse peritoneal macrophages .
25800347	0	IL1b	45,49	Xanthine_oxidoreductase	0,23	IL1b	Xanthine oxidoreductase	3553	7498	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Xanthine_oxidoreductase regulates macrophage IL1b secretion upon NLRP3 inflammasome activation .
16809611	0	IL2	41,44	CD4	64,67	IL2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	BCL11B participates in the activation of IL2 gene expression in CD4 + T lymphocytes .
22371423	0	IL2	21,24	CD4	50,53	IL2	CD4	3558	920	Gene	Gene	role|nmod|START_ENTITY Modeling|dobj|role Modeling|nmod|interplay interplay|nmod|helper helper|nummod|+ +|compound|END_ENTITY	Modeling the role of IL2 in the interplay between CD4 + helper and regulatory T cells : studying the impact of IL2 modulation therapies .
1931717	0	IL2	72,75	IFN_alpha	101,110	IL2	IFN alpha	3558	3439	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|appos|END_ENTITY	Clinical experience with the combined use of recombinant interleukin-2 -LRB- IL2 -RRB- and interferon alfa-2a -LRB- IFN_alpha -RRB- in metastatic_melanoma .
3087589	0	IL2	15,18	IL2_receptor	36,48	IL2	IL2 receptor	3558	3560	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	-LSB- Production of IL2 and induction of IL2_receptor : two independent and dissociable events during allogenic stimulation in vitro in man -RSB- .
2279527	0	IL2	37,40	interleukin-2	23,36	IL2	interleukin-2	3558	3558	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Impaired production of interleukin-2 -LRB- IL2 -RRB- in patients with Graves ' _ disease by newly developed IL2 radioimmunoassay .
8222752	0	IL2	51,54	interleukin-2	36,49	IL2	interleukin-2	280822(Tax:9913)	280822(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regional localization of the bovine interleukin-2 -LRB- IL2 -RRB- gene to chromosome 17q22 -- > q23 by in situ hybridization .
3143716	0	IL2	95,98	p55	69,72	IL2	p55	3558	3559	Gene	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Interleukin_2 -LRB- IL2 -RRB- PE40 is cytotoxic to cells displaying either the p55 or p70 subunit of the IL2 receptor .
15941730	0	IL23A	78,83	interleukin_23	62,76	IL23A	interleukin 23	51561	51561	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin 12 -LRB- IL12B -RRB- , interleukin 12 receptor -LRB- IL12RB1 -RRB- and interleukin_23 -LRB- IL23A -RRB- gene polymorphism in systemic_lupus_erythematosus .
18499543	0	IL23R	27,32	ATG16L1	0,7	IL23R	ATG16L1	149233	55054	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	ATG16L1 and IL23_receptor -LRB- IL23R -RRB- genes are associated with disease susceptibility in Hungarian_CD patients .
22182694	0	IL23R	132,137	CD4	139,142	IL23R	CD4	149233	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Preliminary study : treatment with intramuscular interferon beta-1a results in increased levels of IL-12Rb2 + and decreased levels of IL23R + CD4 + T - Lymphocytes in multiple_sclerosis .
19877036	0	IL23R	30,35	ERAP1	15,20	IL23R	ERAP1	149233	51752	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of ERAP1 , but not IL23R , with ankylosing_spondylitis in a Han Chinese population .
24971461	0	IL23R	115,120	TLR4	54,58	IL23R	TLR4	149233	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
25287681	0	IL28B	51,56	IFNL3	44,49	IL28B	IFNL3	282617	282617	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Detection of allele specific differences in IFNL3 -LRB- IL28B -RRB- mRNA expression .
16698664	0	IL2R	10,14	CD25	16,20	IL2R	CD25	3559	3559	Gene	Gene	level|compound|START_ENTITY level|appos|END_ENTITY	A reduced IL2R -LRB- CD25 -RRB- expression level in first and second degree female relatives of autoimmune_thyroid_disease patients .
10037026	0	IL2R	124,128	interleukin_2_receptor	100,122	IL2R	interleukin 2 receptor	3559	3559	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin_2_receptor -LRB- IL2R -RRB- system : Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery .
3087589	0	IL2_receptor	36,48	IL2	15,18	IL2 receptor	IL2	3560	3558	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	-LSB- Production of IL2 and induction of IL2_receptor : two independent and dissociable events during allogenic stimulation in vitro in man -RSB- .
3139430	0	IL3	39,42	GM-CSF	98,104	IL3	GM-CSF	16187(Tax:10090)	12981(Tax:10090)	Gene	Gene	interleukin_3|appos|START_ENTITY interleukin_3|appos|END_ENTITY	Selective production of interleukin_3 -LRB- IL3 -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in vitro by murine L3T4 + T cells : lack of spontaneous IL3 and GM-CSF production by Ly-2 - / L3T4 - lpr subset .
20738848	0	IL3	41,44	RhoH	26,30	IL3	RhoH	3562	399	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression .
23226269	0	IL3	24,27	interleukin_3	4,17	IL3	interleukin 3	3562	3562	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The interleukin_3 gene -LRB- IL3 -RRB- contributes to human brain volume variation by regulating proliferation and survival of neural progenitors .
8454603	0	IL3	45,48	interleukin_3	30,43	IL3	interleukin 3	3562	3562	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of interleukin_3 -LRB- IL3 -RRB- in primary human T lymphocytes .
18647857	0	IL4	11,14	CD8	15,18	IL4	CD8	3565	925	Gene	Gene	+|nsubj|START_ENTITY +|dobj|cells cells|nummod|END_ENTITY	Regulatory IL4 + CD8 + T cells in patients with ankylosing_spondylitis and healthy controls .
26831416	0	IL4	92,95	IL13	98,102	IL4	IL13	3565	3596	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
8798406	0	IL4	77,80	IL13	96,100	IL4	IL13	3565	3596	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	Receptor for interleukin _ -LRB- IL -RRB- _ 13 does not interact with IL4 but receptor for IL4 interacts with IL13 on human glioma cells .
26831416	0	IL4	92,95	interleukin_4	77,90	IL4	interleukin 4	3565	3565	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
8314773	0	IL4	53,56	interleukin_4	38,51	IL4	interleukin 4	3565	3565	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	A wide range of human cancers express interleukin_4 -LRB- IL4 -RRB- receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin .
1319084	0	IL4R	57,61	interleukin-4_receptor	33,55	IL4R	interleukin-4 receptor	3566	3566	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Histological distribution of the interleukin-4_receptor -LRB- IL4R -RRB- within the normal and pathological synovium .
1679753	0	IL4R	33,37	interleukin-4_receptor	4,26	IL4R	interleukin-4 receptor	3566	3566	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The interleukin-4_receptor gene -LRB- IL4R -RRB- maps to 16p11.2-16p12 .1 in human and to the distal region of mouse chromosome 7 .
20852920	0	IL6	14,17	BNIP3	0,5	IL6	BNIP3	3569	664	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	BNIP3 induces IL6 and calcineurin/NFAT3 hypertrophic-related pathways in H9c2 cardiomyoblast cells .
21535154	0	IL6	23,26	GDF15	16,21	IL6	GDF15	3569	9518	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Erythropoietin , GDF15 , IL6 , hepcidin and testosterone levels in a large cohort of elderly individuals with anaemia of known and unknown cause .
8754861	1	IL6	67,70	Granzyme_A	48,58	IL6	Granzyme A	3569	3001	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	I. Granzyme_A induces IL6 and IL8 production in fibroblast and epithelial cell lines .
15772702	0	IL6	16,19	HLXB9	0,5	IL6	HLXB9	3569	3110	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	HLXB9 activates IL6 in Hodgkin_lymphoma cell lines and is regulated by PI3K signalling involving E2F3 .
26198920	0	IL6	49,52	IL6R	72,76	IL6	IL6R	3569	3570	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Family-based association study of interleukin_6 -LRB- IL6 -RRB- and its receptor -LRB- IL6R -RRB- functional polymorphisms in schizophrenia in the Polish population .
26198920	0	IL6	49,52	IL6R	72,76	IL6	IL6R	3569	3570	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Family-based association study of interleukin_6 -LRB- IL6 -RRB- and its receptor -LRB- IL6R -RRB- functional polymorphisms in schizophrenia in the Polish population .
20826731	0	IL6	93,96	RELA	77,81	IL6	RELA	16193(Tax:10090)	19697(Tax:10090)	Gene	Gene	pathway|nummod|START_ENTITY END_ENTITY|dep|pathway	Neuromedin_B and its receptor induce labor onset and are associated with the RELA -LRB- NFKB_P65 -RRB- / IL6 pathway in pregnant mice .
12044971	0	IL6	11,14	aFGF	30,34	IL6	aFGF	3569	2246	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of IL6 and IL1beta on aFGF expression and excitotoxicity in NT2N cells .
18001296	0	IL6	19,22	interleukin-6	4,17	IL6	interleukin-6	3569	3569	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	The interleukin-6 -LRB- IL6 -RRB- -174 _ G/C promoter genotype is associated with the presence of septic_shock and the ex vivo secretion of IL6 .
9169458	0	IL6	55,58	interleukin-6	40,53	IL6	interleukin-6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	HIV-1 Tat induces the expression of the interleukin-6 -LRB- IL6 -RRB- gene by binding to the IL6 leader RNA and by interacting with CAAT_enhancer-binding_protein beta -LRB- NF-IL6 -RRB- transcription factors .
23662429	0	IL6	100,103	interleukin_6	80,93	IL6	interleukin 6	3569	3569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Allele frequency distributions of -174 G/C polymorphism in regulatory region of interleukin_6 gene -LRB- IL6 -RRB- in Russian and worldwide populations -RSB- .
26198920	0	IL6R	72,76	IL6	49,52	IL6R	IL6	3570	3569	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Family-based association study of interleukin_6 -LRB- IL6 -RRB- and its receptor -LRB- IL6R -RRB- functional polymorphisms in schizophrenia in the Polish population .
26198920	0	IL6R	72,76	IL6	49,52	IL6R	IL6	3570	3569	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Family-based association study of interleukin_6 -LRB- IL6 -RRB- and its receptor -LRB- IL6R -RRB- functional polymorphisms in schizophrenia in the Polish population .
24971461	0	IL6R	103,107	TLR4	54,58	IL6R	TLR4	3570	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
12655571	0	IL6R	65,69	interleukin_6_receptor	36,58	IL6R	interleukin 6 receptor	3570	3570	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of novel SNPs in the interleukin_6_receptor gene -LRB- IL6R -RRB- .
17997171	0	IL6ST	63,68	IL-6	39,43	IL6ST	IL-6	3572	3569	Gene	Gene	transducer|appos|START_ENTITY transducer|compound|END_ENTITY	A non-conservative polymorphism in the IL-6 signal transducer -LRB- IL6ST -RRB- / gp130 is associated with myocardial_infarction in a hypertensive population .
7736792	0	IL6ST	35,40	gp130	6,11	IL6ST	gp130	3572	3572	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human gp130 transducer chain gene -LRB- IL6ST -RRB- is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11 .
9379683	0	IL7	40,43	insulin-like_growth_factor	63,89	IL7	insulin-like growth factor	3574	3479	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of cytokines , including IL4 , IL7 , stem_cell_factor , insulin-like_growth_factor on childhood acute_lymphoblastic_leukemia .
11474182	0	IL7	63,66	interleukin_7	43,56	IL7	interleukin 7	3574	3574	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and assignment of the interleukin_7 gene -LRB- IL7 -RRB- to porcine chromosome 4q11 -- > q13 by FISH and by analysis of radiation hybrid panels .
2786840	0	IL7	34,37	interleukin_7	19,32	IL7	interleukin 7	3574	3574	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for human interleukin_7 -LRB- IL7 -RRB- is at 8q12-13 .
24147013	0	IL7Ra	0,5	IFNb	37,41	IL7Ra	IFNb	3575	3456	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	IL7Ra expression and upregulation by IFNb in dendritic cell subsets is haplotype-dependent .
23163132	0	IL8	12,15	TRAIL	34,39	IL8	TRAIL	3576	8743	Gene	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Erratum to `` IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon_cancer '' -LSB- Clin .
26199092	0	IL8	75,78	miR-302c	66,74	IL8	miR-302c	3576	442895	Gene	Gene	Loop|compound|START_ENTITY Loop|amod|END_ENTITY	Loss of RACK1 Promotes Metastasis of Gastric_Cancer by Inducing a miR-302c / IL8 Signaling Loop .
1680606	0	IL9	72,75	interleukin-9	57,70	IL9	interleukin-9	3578	3578	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Regional localization of the human glutaminase -LRB- GLS -RRB- and interleukin-9 -LRB- IL9 -RRB- genes by in situ hybridization .
8666384	0	IL9R	24,28	IL-9_receptor	4,17	IL9R	IL-9 receptor	3581	3581	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The IL-9_receptor gene -LRB- IL9R -RRB- : genomic structure , chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes , and identification of IL9R pseudogenes at 9qter , 10pter , 16pter , and 18pter .
8974006	0	ILF2	52,56	interleukin_enhancer_binding_factor_2	8,45	ILF2	interleukin enhancer binding factor 2	3608	3608	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping interleukin_enhancer_binding_factor_2 gene -LRB- ILF2 -RRB- to human chromosome 1 -LRB- 1q11-qter and 1p11-p12 -RRB- by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates .
11167023	0	ILF3	73,77	interleukin_enhancer_binding_factor_3	34,71	ILF3	interleukin enhancer binding factor 3	3609	3609	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternative splicing in the human interleukin_enhancer_binding_factor_3 -LRB- ILF3 -RRB- gene .
9620363	0	ILF3	52,56	interleukin_enhancer_binding_factor_3	8,45	ILF3	interleukin enhancer binding factor 3	3609	3609	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping interleukin_enhancer_binding_factor_3 gene -LRB- ILF3 -RRB- to human chromosome 19 -LRB- 19q11-qter and 19p11-p13 .1 -RRB- by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates .
10215450	0	ILGF-1	96,102	EPO	57,60	ILGF-1	EPO	3479	2056	Gene	Gene	erythropoietin|appos|START_ENTITY erythropoietin|appos|END_ENTITY	The relationship between serum levels of erythropoietin -LRB- EPO -RRB- and insulin-like_growth_factor-1 -LRB- ILGF-1 -RRB- and hematocrit -LRB- HCT -RRB- in breast_cancer patients receiving non-nephrotoxic chemotherapy .
20232298	0	ILK	37,40	BMP-2	16,21	ILK	BMP-2	3611	650	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Hypoxia induces BMP-2 expression via ILK , Akt , mTOR , and HIF-1 pathways in osteoblasts .
17498677	0	ILK	59,62	ERK1/2	8,14	ILK	ERK1/2	3611	5595;5594	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression Role|nmod|regulation Role|nmod|END_ENTITY	Role of ERK1/2 and PI3-K in the regulation of CTGF-induced ILK expression in HK-2 cells .
15105053	0	ILK	24,27	Integrin-linked_kinase	0,22	ILK	Integrin-linked kinase	3611	3611	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Integrin-linked_kinase -LRB- ILK -RRB- regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398 .
22814720	0	ILK	24,27	Integrin-linked_kinase	0,22	ILK	Integrin-linked kinase	3611	3611	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Integrin-linked_kinase -LRB- ILK -RRB- expression correlates with tumor severity in clear_cell_renal_carcinoma .
11687976	0	ILK	22,25	hDab-2	6,12	ILK	hDab-2	3611	1601	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	DOC-2 / hDab-2 inhibits ILK activity and induces anoikis in breast_cancer cells through an Akt-independent pathway .
10716737	0	ILK	38,41	integrin-linked_kinase	14,36	ILK	integrin-linked kinase	3611	3611	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of integrin-linked_kinase -LRB- ILK -RRB- suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate_cancer cells .
12884912	0	ILK	36,39	integrin-linked_kinase	12,34	ILK	integrin-linked kinase	3611	3611	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of integrin-linked_kinase -LRB- ILK -RRB- in cancer progression .
15970428	0	ILK	56,59	integrin-linked_kinase	32,54	ILK	integrin-linked kinase	16202(Tax:10090)	16202(Tax:10090)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Differential involvement of the integrin-linked_kinase -LRB- ILK -RRB- in RhoA-dependent rearrangement of F-actin fibers and induction of connective_tissue_growth_factor -LRB- CTGF -RRB- .
16643659	0	ILK	38,41	integrin-linked_kinase	14,36	ILK	integrin-linked kinase	3611	3611	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of integrin-linked_kinase -LRB- ILK -RRB- expression in human oesophageal_squamous_cell_carcinoma cell lines by the EGF and TGFbeta1 growth factors .
23108908	0	ILK	42,45	integrin-linked_kinase	18,40	ILK	integrin-linked kinase	3611	3611	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of integrin-linked_kinase -LRB- ILK -RRB- is associated with tumor progression and an unfavorable prognosis in patients with colorectal_cancer .
24045896	0	ILK	42,45	integrin-linked_kinase	18,40	ILK	integrin-linked kinase	3611	3611	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of integrin-linked_kinase -LRB- ILK -RRB- promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-kB pathway .
24360977	0	ILK	42,45	integrin-linked_kinase	18,40	ILK	integrin-linked kinase	3611	3611	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of integrin-linked_kinase -LRB- ILK -RRB- promotes migration and invasion of colorectal_cancer cells by inducing epithelial-mesenchymal transition via NF-kB signaling .
25800559	0	ILP-2	68,73	Birc-8	61,67	ILP-2	Birc-8	112401	112401	Gene	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	Fumonisin_B inhibits apoptosis in HepG2 cells by inducing Birc-8 / ILP-2 .
12853576	0	ILT2	49,53	CD8	77,80	ILT2	CD8	10859	925	Gene	Gene	Ig-like_transcript_2|appos|START_ENTITY compete|nsubj|Ig-like_transcript_2 compete|nmod|END_ENTITY	Human inhibitory receptors Ig-like_transcript_2 -LRB- ILT2 -RRB- and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G .
14592815	0	ILT2	99,103	CD8	18,21	ILT2	CD8	10859	925	Gene	Gene	ligand|appos|START_ENTITY express|dobj|ligand express|nsubj|+ +|nummod|END_ENTITY	Primary cutaneous CD8 + and CD56 + T-cell_lymphomas express HLA-G and killer-cell inhibitory ligand , ILT2 .
15100307	0	ILT2	62,66	CD8	70,73	ILT2	CD8	10859	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Specific recognition of the viral protein UL18 by CD85j/LIR -1 / ILT2 on CD8 + T cells mediates the non-MHC-restricted lysis of human_cytomegalovirus-infected cells .
21213105	0	ILT2	22,26	CD8	59,62	ILT2	CD8	10859	925	Gene	Gene	receptor|compound|START_ENTITY receptor|dep|inhibitor inhibitor|nmod|T T|compound|END_ENTITY	High affinity soluble ILT2 receptor : a potent inhibitor of CD8 -LRB- + -RRB- T cell activation .
14592815	0	ILT2	99,103	HLA-G	58,63	ILT2	HLA-G	10859	3135	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	Primary cutaneous CD8 + and CD56 + T-cell_lymphomas express HLA-G and killer-cell inhibitory ligand , ILT2 .
11857488	0	ILT2	104,108	HLA-G_antigen	68,81	ILT2	HLA-G antigen	10859	3135	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Specific activation of the non-classical class I histocompatibility HLA-G_antigen and expression of the ILT2 inhibitory receptor in human breast_cancer .
18652845	0	ILT2	49,53	ILT3	55,59	ILT2	ILT3	10859	11006	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Rapamycin downregulates the inhibitory receptors ILT2 , ILT3 , ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction .
18652845	0	ILT2	49,53	ILT4	61,65	ILT2	ILT4	10859	10288	Gene	Gene	receptors|nummod|START_ENTITY inhibitory|dep|receptors END_ENTITY|amod|inhibitory	Rapamycin downregulates the inhibitory receptors ILT2 , ILT3 , ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction .
11410407	0	ILT2	23,27	LIR-1	29,34	ILT2	LIR-1	10859	10859	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	High expression of the ILT2 -LRB- LIR-1 -RRB- inhibitory receptor for major histocompatibility complex class I molecules on clonal expansions of T large granular lymphocytes in asymptomatic patients .
22005288	0	ILT3	82,86	CD34	115,119	ILT3	CD34	11006	947	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Induction of CD4 + CD25 + Foxp3 + T regulatory cells by dendritic cells derived from ILT3 lentivirus-transduced human CD34 + cells .
18652845	0	ILT3	55,59	ILT2	49,53	ILT3	ILT2	11006	10859	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Rapamycin downregulates the inhibitory receptors ILT2 , ILT3 , ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction .
15226269	0	ILT3	64,68	ILT4	70,74	ILT3	ILT4	11006	10288	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Alloantigen specific CD8 + CD28 - FOXP3 + T suppressor cells induce ILT3 + ILT4 + tolerogenic endothelial cells , inhibiting alloreactivity .
18652845	0	ILT3	55,59	ILT4	61,65	ILT3	ILT4	11006	10288	Gene	Gene	receptors|nummod|START_ENTITY inhibitory|dep|receptors END_ENTITY|amod|inhibitory	Rapamycin downregulates the inhibitory receptors ILT2 , ILT3 , ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction .
22159546	0	ILT3	1,5	ILT4	7,11	ILT3	ILT4	11006	10288	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	-LSB- ILT3 + / ILT4 + tolerogenic dendritic cells and their influence on allograft survival -RSB- .
18652845	0	ILT4	61,65	ILT2	49,53	ILT4	ILT2	10288	10859	Gene	Gene	START_ENTITY|amod|inhibitory inhibitory|dep|receptors receptors|nummod|END_ENTITY	Rapamycin downregulates the inhibitory receptors ILT2 , ILT3 , ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction .
15226269	0	ILT4	70,74	ILT3	64,68	ILT4	ILT3	10288	11006	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Alloantigen specific CD8 + CD28 - FOXP3 + T suppressor cells induce ILT3 + ILT4 + tolerogenic endothelial cells , inhibiting alloreactivity .
18652845	0	ILT4	61,65	ILT3	55,59	ILT4	ILT3	10288	11006	Gene	Gene	START_ENTITY|amod|inhibitory inhibitory|dep|receptors receptors|nummod|END_ENTITY	Rapamycin downregulates the inhibitory receptors ILT2 , ILT3 , ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 induction .
22159546	0	ILT4	7,11	ILT3	1,5	ILT4	ILT3	10288	11006	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	-LSB- ILT3 + / ILT4 + tolerogenic dendritic cells and their influence on allograft survival -RSB- .
24899637	0	ILT6	35,39	Immunoglobulin-like_transcripts_6	0,33	ILT6	Immunoglobulin-like transcripts 6	11026	11026	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Immunoglobulin-like_transcripts_6 -LRB- ILT6 -RRB- polymorphism influences the anti-Ro60 / 52 autoantibody status in South Indian SLE patients .
23238213	0	ILT6	28,32	LILRA3	20,26	ILT6	LILRA3	11026	11026	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	6.7-kbp deletion in LILRA3 -LRB- ILT6 -RRB- gene is associated with later onset of the multiple_sclerosis in a Polish population .
10550547	0	IL_10	20,25	IFN-alpha	0,9	IL 10	IFN-alpha	3586	3439	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	IFN-alpha regulates IL_10 production by CML cells in vitro .
2945863	0	IL_2	12,16	BCL1	149,153	IL 2	BCL1	16183(Tax:10090)	12443(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|clone clone|nmod|cells cells|appos|END_ENTITY	Recombinant IL_2 but not recombinant interferon-gamma stimulates both proliferation and IgM secretion in a Ly-1 + clone of neoplastic murine B cells -LRB- BCL1 -RRB- .
3102601	0	IL_2	30,34	BCL1	77,81	IL 2	BCL1	3558	595	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Demonstration of up-regulated IL_2 receptor expression on an in vitro cloned BCL1 subline .
2951262	0	IL_2	145,149	BSF-1	107,112	IL 2	BSF-1	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Bone_marrow_pro-T and pro-B lymphocyte clones express functional receptors for interleukin _ -LRB- IL -RRB- _ 3 and IL_4 / BSF-1 and nonfunctional receptors for IL_2 .
3926887	0	IL_2	49,53	IL_2	62,66	IL 2	IL 2	3558	3558	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mechanisms of human T cell response to mitogens : IL_2 induces IL_2 receptor expression and proliferation but not IL_2 synthesis in PHA-stimulated T cells .
3926887	0	IL_2	62,66	IL_2	49,53	IL 2	IL 2	3558	3558	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mechanisms of human T cell response to mitogens : IL_2 induces IL_2 receptor expression and proliferation but not IL_2 synthesis in PHA-stimulated T cells .
2338453	0	IL_2	15,19	Interleukin_2	0,13	IL 2	Interleukin 2	3558	3558	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Interleukin_2 -LRB- IL_2 -RRB- inhibitor in rheumatoid synovial fluid : correlation with prognosis and soluble IL_2 receptor levels .
1953054	0	IL_2	76,80	TNF_alpha	46,55	IL 2	TNF alpha	3558	7124	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY tumor_necrosis_factor_alpha|appos|END_ENTITY	Determination of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- and interleukin_2 -LRB- IL_2 -RRB- in women with idiopathic_recurrent_miscarriage .
1999222	0	IL_2	51,55	interleukin_2	36,49	IL 2	interleukin 2	3558	3558	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	T cell activation in the absence of interleukin_2 -LRB- IL_2 -RRB- results in the induction of high-affinity IL_2 receptor unable to transmit a proliferative signal .
2973414	0	IL_2	57,61	interleukin_2	42,55	IL 2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Comparison of the structure of the murine interleukin_2 -LRB- IL_2 -RRB- receptor on cytotoxic and helper T cell lines by chemical cross-linking of 125I-labeled IL_2 .
3876375	0	IL_2	29,33	interleukin_2	14,27	IL 2	interleukin 2	3558	3558	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of interleukin_2 -LRB- IL_2 -RRB- by salivary gland lymphocytes in Sj __ gren 's _ syndrome .
2318250	0	IL_2	92,96	p55	31,34	IL 2	p55	16183(Tax:10090)	17524(Tax:10090)	Gene	Gene	responsiveness|nummod|START_ENTITY control|dobj|responsiveness control|nsubj|level level|nmod|component component|amod|END_ENTITY	Evidence that the level of the p55 component of the interleukin -LRB- IL -RRB- 2 receptor can control IL_2 responsiveness in a murine IL_3-dependent cell .
8516548	0	IL_2	29,33	p55	1,4	IL 2	p55	3558	3559	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	-LSB- p55 and p75 subunits of the IL_2 receptor , membrane bound and soluble , in peripheral lymphocytes in patients with solid tumors -RSB- .
3259477	0	IL_2	74,78	transferrin	28,39	IL 2	transferrin	3558	7018	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Simultaneous measurement of transferrin receptor and DNA content of human IL_2 dependent T cells by flow cytometry .
1370410	4	IL_2R	796,801	p55	802,805	IL 2R	p55	3560	3559	Gene	Gene	chain|compound|START_ENTITY chain|amod|END_ENTITY	Incubation with IL_2 alone or irradiated target cells alone could induce expression of the IL_2R p55 chain by both CD56bright and CD56dim NK cells ; a combination of both stimuli was most effective .
3114369	0	IL_4	52,56	interleukin_4	37,50	IL 4	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Interleukin 1-mediated activation of interleukin_4 -LRB- IL_4 -RRB- - producing T lymphocytes .
1978708	0	IL_5	49,53	TH2	123,126	IL 5	TH2	16191(Tax:10090)	15111(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Induction of antibody synthesis by CD4 + T cells : IL_5 is essential for induction of antigen-specific antibody responses by TH2 but not TH1 clones .
16520310	0	IMF_and_BF	75,85	MC4R	40,44	IMF and BF	MC4R	100326761(Tax:9823)	397359(Tax:9823)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	-LSB- Distributions of polymorphism of ADD1 , MC4R , H-FABP gene , associated with IMF_and_BF in 3 populations in pig -RSB- .
24147952	0	IMP1	60,64	C-myc	87,92	IMP1	C-myc	10642	4609	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	IMP1	60,64	P16	66,69	IMP1	P16	10642	1029	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	IMP1	60,64	P53	55,58	IMP1	P53	10642	7157	Gene	Gene	Survivn|appos|START_ENTITY Survivn|compound|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	IMP1	60,64	P62	82,85	IMP1	P62	10642	23636	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
23911878	0	IMP1	0,4	RSK2	86,90	IMP1	RSK2	10642	6197	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1 .
24147952	0	IMP1	60,64	cyclin_B1	71,80	IMP1	cyclin B1	10642	891	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
22266872	0	IMP3	14,18	EGFR	22,26	IMP3	EGFR	55272	1956	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Regulation of IMP3 by EGFR signaling and repression by ERb : implications for triple-negative breast_cancer .
26158423	0	IMP3	63,67	Lin28B	43,49	IMP3	Lin28B	55272	389421	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 -LRB- IMP3 -RRB- is associated with chemoresistance and poor disease outcome in ovarian_cancer .
25982283	0	IMP3	0,4	SLUG	82,86	IMP3	SLUG	10643	6591	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	IMP3 promotes stem-like properties in triple-negative_breast_cancer by regulating SLUG .
25982283	0	IMP3	0,4	SLUG	82,86	IMP3	SLUG	10643	6591	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	IMP3 promotes stem-like properties in triple-negative_breast_cancer by regulating SLUG .
23570281	0	IMP3	17,21	TFF3	10,14	IMP3	TFF3	55272	7033	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	ER + / PR + / TFF3 + / IMP3 - immunoprofile distinguishes endometrioid from serous and clear_cell_carcinomas of the endometrium : a study of 401 cases .
19192721	0	IMP3	68,72	insulin-like_growth_factor-II_mRNA_binding_protein_3	14,66	IMP3	insulin-like growth factor-II mRNA binding protein 3	55272	55272	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor-II_mRNA_binding_protein_3 -LRB- IMP3 -RRB- in osteosarcoma .
22500655	0	IMP3	56,60	insulin-like_growth_factor_mRNA-binding_protein_3	5,54	IMP3	insulin-like growth factor mRNA-binding protein 3	55272	55272	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	High insulin-like_growth_factor_mRNA-binding_protein_3 -LRB- IMP3 -RRB- protein expression is associated with poor survival in muscle-invasive bladder_cancer .
15504365	0	IMPA2	60,65	inositol_monophosphatase_2	32,58	IMPA2	inositol monophosphatase 2	3613	3613	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Lithium modulation of the human inositol_monophosphatase_2 -LRB- IMPA2 -RRB- promoter .
11317223	0	IMPA2	64,69	myo-inositol_monophosphatase_2	32,62	IMPA2	myo-inositol monophosphatase 2	3613	3613	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence for association of the myo-inositol_monophosphatase_2 -LRB- IMPA2 -RRB- gene with schizophrenia in Japanese samples .
7905856	0	IMPDHL1	82,89	IMP_dehydrogenase-like_locus	52,80	IMPDHL1	IMP dehydrogenase-like locus	727833	727833	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Identification and regional localization of a human IMP_dehydrogenase-like_locus -LRB- IMPDHL1 -RRB- at 16p13 .13 .
10601738	0	IMPG1	53,58	IPM_150	39,46	IMPG1	IPM 150	3617	3617	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Expression and characterization of the IPM_150 gene -LRB- IMPG1 -RRB- product , a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan .
9691169	0	IMPG1	99,104	interphotoreceptor_matrix_proteoglycan-1	57,97	IMPG1	interphotoreceptor matrix proteoglycan-1	3617	3617	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and chromosomal localization of the interphotoreceptor_matrix_proteoglycan-1 -LRB- IMPG1 -RRB- gene : a candidate for 6q-linked_retinopathies .
9719369	0	IMPG1	60,65	interphotoreceptor_matrix_proteoglycan-1	18,58	IMPG1	interphotoreceptor matrix proteoglycan-1	3617	3617	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assessment of the interphotoreceptor_matrix_proteoglycan-1 -LRB- IMPG1 -RRB- gene localised to 6q13-q15 in autosomal_dominant_Stargardt-like_disease -LRB- ADSTGD -RRB- , progressive bifocal chorioretinal_atrophy -LRB- PBCRA -RRB- , and North Carolina_macular_dystrophy -LRB- MCDR1 -RRB- .
7905856	0	IMP_dehydrogenase-like_locus	52,80	IMPDHL1	82,89	IMP dehydrogenase-like locus	IMPDHL1	727833	727833	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Identification and regional localization of a human IMP_dehydrogenase-like_locus -LRB- IMPDHL1 -RRB- at 16p13 .13 .
12551726	0	IMPase_1	58,66	inositol_monophosphatase_1	30,56	IMPase 1	inositol monophosphatase 1	83523(Tax:10116)	83523(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regional changes in rat brain inositol_monophosphatase_1 -LRB- IMPase_1 -RRB- activity with chronic lithium treatment .
25949126	0	IMUP-2	49,55	Immortalization-Upregulated_Protein-2	10,47	IMUP-2	Immortalization-Upregulated Protein-2	64073	64073	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of Immortalization-Upregulated_Protein-2 -LRB- IMUP-2 -RRB- on Cell Death of Trophoblast .
25799587	0	INAD	84,88	Inactivation_No_Afterpotential_D	50,82	INAD	Inactivation No Afterpotential D	37629(Tax:7227)	37629(Tax:7227)	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	Light-Dependent Phosphorylation of the Drosophila Inactivation_No_Afterpotential_D -LRB- INAD -RRB- Scaffolding Protein at Thr170 and Ser174 by Eye-Specific Protein Kinase C. Drosophila inactivation_no_afterpotential_D -LRB- INAD -RRB- is a PDZ domain-containing scaffolding protein that tethers components of the phototransduction cascade to form a supramolecular signaling complex .
10996078	0	INCENP	0,6	AIRK2	39,44	INCENP	AIRK2	3619	398457(Tax:8355)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes , the central spindle and cleavage furrow .
15866179	0	INCENP	36,42	Aurora_B	13,21	INCENP	Aurora B	3619	9212	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of Aurora_B activation by INCENP and inhibition by hesperadin .
18767990	0	INCENP	22,28	Aurora_B	32,40	INCENP	Aurora B	3619	9212	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	The catalytic role of INCENP in Aurora_B activation and the kinetic mechanism of Aurora_B / INCENP .
18767990	0	INCENP	90,96	Aurora_B	32,40	INCENP	Aurora B	3619	9212	Gene	Gene	START_ENTITY|nsubj|role role|nmod|INCENP INCENP|nmod|activation activation|compound|END_ENTITY	The catalytic role of INCENP in Aurora_B activation and the kinetic mechanism of Aurora_B / INCENP .
18767990	0	INCENP	22,28	INCENP	90,96	INCENP	INCENP	3619	3619	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The catalytic role of INCENP in Aurora_B activation and the kinetic mechanism of Aurora_B / INCENP .
18767990	0	INCENP	90,96	INCENP	22,28	INCENP	INCENP	3619	3619	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The catalytic role of INCENP in Aurora_B activation and the kinetic mechanism of Aurora_B / INCENP .
22920039	0	INCENP	52,58	aurora_B	27,35	INCENP	aurora B	3619	9212	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human aurora_B in complex with INCENP and VX-680 .
15316025	0	INCENP	50,56	inner_centromere_protein	24,48	INCENP	inner centromere protein	3619	3619	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Direct association with inner_centromere_protein -LRB- INCENP -RRB- activates the novel chromosomal passenger protein , Aurora-C .
25586992	0	INCENP	52,58	inner_centromere_protein	26,50	INCENP	inner centromere protein	3619	3619	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Inherited variants in the inner_centromere_protein -LRB- INCENP -RRB- gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast_cancer .
1899303	0	INF-gamma	75,84	interferon-gamma	57,73	INF-gamma	interferon-gamma	3458	3458	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The use of polymerase chain reaction -LRB- PCR -RRB- for assessing interferon-gamma -LRB- INF-gamma -RRB- mRNA levels in human lymphocytes .
20493814	0	INF2	11,15	Cdc42	101,106	INF2	Cdc42	490877(Tax:9615)	403934(Tax:9615)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2 .
20881207	0	INF2	7,11	Lck	48,51	INF2	Lck	64423	3932	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transport transport|nmod|END_ENTITY	Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes .
17763999	0	ING1	46,50	inhibitor_of_growth_1	23,44	ING1	inhibitor of growth 1	3621	3621	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Down-regulation of the inhibitor_of_growth_1 -LRB- ING1 -RRB- tumor suppressor sensitizes p53-deficient glioblastoma cells to cisplatin-induced cell death .
11991811	0	ING1	69,73	inhibitor_of_growth_1_gene	41,67	ING1	inhibitor of growth 1 gene	3621	3621	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Comparative assessment expression of the inhibitor_of_growth_1_gene -LRB- ING1 -RRB- in normal and neoplastic tissues .
11835353	0	ING1	40,44	p33	36,39	ING1	p33	3621	3621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression and sequence analyses of p33 -LRB- ING1 -RRB- gene in myeloid_leukemia .
20621832	0	ING2	58,62	Smurf1	22,28	ING2	Smurf1	3622	57154	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation .
24157826	0	ING4	0,4	JWA	15,18	ING4	JWA	51147	10550	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	ING4 regulates JWA in angiogenesis and their prognostic value in melanoma patients .
20381459	0	ING4	21,25	MicroRNA-650	0,12	ING4	MicroRNA-650	51147	723778	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-650 targets ING4 to promote gastric_cancer tumorigenicity .
19250543	0	ING4	60,64	inhibitor_of_growth_family_member_4	23,58	ING4	inhibitor of growth family member 4	51147	51147	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of the inhibitor_of_growth_family_member_4 -LRB- ING4 -RRB- in different forms of pulmonary_fibrosis .
15882981	0	ING4	31,35	p53	71,74	ING4	p53	51147	7157	Gene	Gene	signal|nmod|START_ENTITY plays|nsubj|signal plays|nmod|END_ENTITY	Nuclear localization signal of ING4 plays a key role in its binding to p53 .
23967213	0	ING4	4,8	p53	22,25	ING4	p53	51147	7157	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human_Papillomavirus_16 E6 .
17709882	0	INGAP	49,54	islet_neogenesis-associated_protein	12,47	INGAP	islet neogenesis-associated protein	5068	5068	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of islet_neogenesis-associated_protein -LRB- INGAP -RRB- in islet neogenesis .
9151782	0	INGAP	78,83	islet_neogenesis_associated_protein	41,76	INGAP	islet neogenesis associated protein	5068	5068	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and sequencing of the pancreatic islet_neogenesis_associated_protein -LRB- INGAP -RRB- gene and its expression in islet neogenesis in hamsters .
25111790	0	INHA	23,27	Inhibin_alpha-subunit	0,21	INHA	Inhibin alpha-subunit	3623	3623	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibin_alpha-subunit -LRB- INHA -RRB- expression in adrenocortical_cancer is linked to genetic and epigenetic INHA promoter variation .
21566516	0	INI1	118,122	SMARCB1	109,116	INI1	SMARCB1	6598	6598	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nonsense mutation and inactivation of SMARCA4 -LRB- BRG1 -RRB- in an atypical teratoid/rhabdoid _ tumor showing retained SMARCB1 -LRB- INI1 -RRB- expression .
22949514	0	INI1	23,27	SMARCB1	14,21	INI1	SMARCB1	6598	6598	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of SMARCB1 -LRB- INI1 -RRB- mutations in familial_schwannomatosis .
11700040	0	INK4	23,27	CIP1	37,41	INK4	CIP1	1029	1026	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Influence of human p16 -LRB- INK4 -RRB- and p21 -LRB- CIP1 -RRB- on the in vitro activity of recombinant Plasmodium_falciparum cyclin-dependent protein kinases .
12169206	0	INK4	24,28	FHIT	7,11	INK4	FHIT	1029	2272	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	MYCL1 , FHIT , SPARC , p16 -LRB- INK4 -RRB- and TP53 genes associated to lung_cancer in idiopathic_pulmonary_fibrosis .
10585280	0	INK4	94,98	KIP1	108,112	INK4	KIP1	1029	1027	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16 -LRB- INK4 -RRB- and p27 -LRB- KIP1 -RRB- to CDKs , loss of E2F-binding activity , and premature senescence of human melanocytes .
12169206	0	INK4	24,28	SPARC	13,18	INK4	SPARC	1029	6678	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	MYCL1 , FHIT , SPARC , p16 -LRB- INK4 -RRB- and TP53 genes associated to lung_cancer in idiopathic_pulmonary_fibrosis .
10799744	0	INK4	12,16	p16	8,11	INK4	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Loss of p16 -LRB- INK4 -RRB- protein , alone and together with loss of retinoblastoma protein , correlate with hepatocellular_carcinoma progression .
25457887	0	INK4	4,8	p16	0,3	INK4	p16	1029	1029	Gene	Gene	Expression|appos|START_ENTITY Expression|amod|END_ENTITY	p16 -LRB- INK4 -RRB- Expression is not associated with human_papillomavirus_in_oral_lichen_planus .
8910511	0	INK4	32,36	p16	28,31	INK4	p16	1029	1029	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Defective folding of mutant p16 -LRB- INK4 -RRB- proteins encoded by tumor-derived alleles .
7739547	0	INK4	6,10	p19	21,24	INK4	p19	1029	12581(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Novel INK4 proteins , p19 and p18 , are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6 .
16998811	0	INK4A	64,69	EZH2	49,53	INK4A	EZH2	1029	2146	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
11932901	0	INK4A	111,116	FHIT	102,106	INK4A	FHIT	1029	2272	Gene	Gene	p16|appos|START_ENTITY END_ENTITY|appos|p16	Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT , p16 -LRB- INK4A -RRB- , and p19 -LRB- ARF -RRB- genes in nasopharyngeal_carcinoma .
10556039	0	INK4A	76,81	INK4C	91,96	INK4A	INK4C	1029	1031	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Tumor suppressor INK4 : comparisons of conformational properties between p16 -LRB- INK4A -RRB- and p18 -LRB- INK4C -RRB- .
16317707	0	INK4A	52,57	P16	48,51	INK4A	P16	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Role of HSP90 , CDC37 , and CRM1 as modulators of P16 -LRB- INK4A -RRB- activity in rat liver carcinogenesis and human liver_cancer .
16998811	0	INK4A	64,69	VEGF	43,47	INK4A	VEGF	1029	7422	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
21174181	0	INK4A	100,105	cyclin_B1	35,44	INK4A	cyclin B1	1029	891	Gene	Gene	expression|appos|START_ENTITY expression|nmod|protein protein|amod|END_ENTITY	Aberrant cytoplasmic expression of cyclin_B1 protein and its correlation with EBV-LMP1 , P53 and P16 -LRB- INK4A -RRB- in classical Hodgkin_lymphoma in China .
11102889	0	INK4A	93,98	cyclin_D1	113,122	INK4A	cyclin D1	1029	595	Gene	Gene	p16|appos|START_ENTITY p16|amod|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11751403	0	INK4A	32,37	cyclin_D1	14,23	INK4A	cyclin D1	12578(Tax:10090)	12443(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cyclin_D1 and p16 -LRB- INK4A -RRB- is critical for growth arrest during mammary involution .
21467228	0	INK4A	66,71	epidermal_growth_factor_receptor	21,53	INK4A	epidermal growth factor receptor	1029	1956	Gene	Gene	status|appos|START_ENTITY status|compound|END_ENTITY	Relationship between epidermal_growth_factor_receptor status , p16 -LRB- INK4A -RRB- , and outcome in head_and_neck_squamous_cell_carcinoma .
21747645	0	INK4A	28,33	hMLH1	36,41	INK4A	hMLH1	1029	4292	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Promoter methylation of p16 -LRB- INK4A -RRB- , hMLH1 , and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence .
15312681	0	INK4A	33,38	p14	20,23	INK4A	p14	1029	1029	Gene	Gene	expression|compound|START_ENTITY Correlation|dep|expression Correlation|nmod|END_ENTITY	Correlation between p14 -LRB- ARF -RRB- / p16 -LRB- INK4A -RRB- expression and HPV_infection_in_uterine_cervical_cancer .
10567907	0	INK4A	38,43	p16	34,37	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA methylation and expression of p16 -LRB- INK4A -RRB- gene in pulmonary_adenocarcinoma and anthracosis in background lung .
10649246	0	INK4A	36,41	p16	32,35	INK4A	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Differential_retinoblastoma and p16 -LRB- INK4A -RRB- protein expression in neuroendocrine_tumors of the lung .
10679192	0	INK4A	98,103	p16	94,97	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Retinoic_acid extends the in vitro life span of normal human oral keratinocytes by decreasing p16 -LRB- INK4A -RRB- expression and maintaining telomerase activity .
11165758	0	INK4A	61,66	p16	57,60	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High frequency of homozygous deletion and methylation of p16 -LRB- INK4A -RRB- gene in oral_squamous_cell_carcinomas .
11171828	0	INK4A	41,46	p16	37,40	INK4A	p16	1029	1029	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Detection of hypermethylation of the p16 -LRB- INK4A -RRB- gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C_virus .
11291057	0	INK4A	22,27	p16	18,21	INK4A	p16	1029	1029	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of p16 -LRB- INK4A -RRB- as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri .
12970888	4	INK4A	606,611	p16	602,605	INK4A	p16	1029	1029	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	The methylation status of p16 -LRB- INK4A -RRB- promoter in HT-29 cells was also determined by methylation-specific PCR -LRB- MSP -RRB- .
14500697	0	INK4A	4,9	p16	0,3	INK4A	p16	1029	1029	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|END_ENTITY	p16 -LRB- INK4A -RRB- immunohistochemical overexpression in premalignant and malignant_oral_lesions infected with human_papillomavirus .
15312681	0	INK4A	33,38	p16	29,32	INK4A	p16	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Correlation between p14 -LRB- ARF -RRB- / p16 -LRB- INK4A -RRB- expression and HPV_infection_in_uterine_cervical_cancer .
15312681	8	INK4A	1120,1125	p16	1116,1119	INK4A	p16	1029	1029	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	In four HPV-negative_cancers , reduced expression of p14 -LRB- ARF -RRB- mRNA was detected in two cases -LRB- 50 % -RRB- and reduced p16 -LRB- INK4A -RRB- mRNA in three cases -LRB- 75 % -RRB- .
15381905	0	INK4A	4,9	p16	0,3	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p16 -LRB- INK4A -RRB- expression is related to grade of cin and high-risk human_papillomavirus but does not predict virus clearance after conization or disease outcome .
16175083	0	INK4A	114,119	p16	110,113	INK4A	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Abnormalities of the RB1 pathway in ovarian_serous_papillary_carcinoma as determined by overexpression of the p16 -LRB- INK4A -RRB- protein .
16540739	0	INK4A	13,18	p16	8,11	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of p16 -LRB- INK4A -RRB- expression is associated with allelic_imbalance / loss of heterozygosity of chromosome 9p21 in microdissected malignant_peripheral_nerve_sheath_tumors .
17069677	0	INK4A	14,19	p16	10,13	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Study of p16 -LRB- INK4A -RRB- expression and DNA ploidy in HPV-negative_cervical_cancers and precursors -RSB- .
17415114	0	INK4A	38,43	p16	34,37	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of p16 -LRB- INK4A -RRB- in normal uterine cervix , nonneoplastic epithelial lesions , and low-grade squamous intraepithelial lesions .
18058237	0	INK4A	18,23	p16	14,17	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of p16 -LRB- INK4A -RRB- gene in human pituitary_tumours .
18346352	0	INK4A	35,40	p16	31,34	INK4A	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	-LSB- Role of HPV DNA detection and p16 -LRB- INK4A -RRB- protein expression in diagnosis of endocervical_adenocarcinoma -RSB- .
19016326	0	INK4A	43,48	p16	39,42	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Progression of hypermethylation of the p16 -LRB- INK4A -RRB- gene from normal liver to nontumorous liver_and_hepatocellular_carcinoma : an evaluation using quantitative PCR analysis .
19125298	0	INK4A	26,31	p16	22,25	INK4A	p16	1029	1029	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast_cancer .
19732323	0	INK4A	60,65	p16	56,59	INK4A	p16	1029	1029	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Hepatitis_B_virus X protein induces hypermethylation of p16 -LRB- INK4A -RRB- promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis .
20620135	0	INK4A	61,66	p16	57,60	INK4A	p16	1029	1029	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Hepatitis_B_virus X protein promotes hypermethylation of p16 -LRB- INK4A -RRB- promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis .
20955378	0	INK4A	38,43	p16	34,37	INK4A	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Immunohistochemical expression of p16 -LRB- INK4A -RRB- protein as a helpful marker of a subset of potentially malignant oral epithelial lesions : study on a series with long-term follow-up .
21166704	0	INK4A	83,88	p16	79,82	INK4A	p16	1029	1029	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|END_ENTITY	Primary_squamous_cell_carcinoma_of_the_vagina : human_papillomavirus detection , p16 -LRB- INK4A -RRB- overexpression and clinicopathological correlations .
21290054	0	INK4A	19,24	p16	15,18	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Correlation of p16 -LRB- INK4A -RRB- expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical_cancer cells .
21533340	0	INK4A	89,94	p16	85,88	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Growth suppression of non-small_cell_lung_carcinoma cells by the introduction of the p16 -LRB- INK4A -RRB- gene .
21612953	0	INK4A	38,43	p16	34,37	INK4A	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Immunohistochemical expression of p16 -LRB- INK4A -RRB- protein in oral_lichen_planus .
22354873	0	INK4A	16,21	p16	12,15	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of p16 -LRB- INK4A -RRB- expression of oral_squamous_cell_carcinomas in Taiwan : prognostic correlation without relevance to betel quid consumption .
22724384	0	INK4A	12,17	p16	8,11	INK4A	p16	1029	1029	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A novel p16 -LRB- INK4A -RRB- mutation associated with esophageal_squamous_cell_carcinoma in a high risk population .
22924132	0	INK4A	12,17	p16	8,11	INK4A	p16	1029	1029	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of p16 -LRB- INK4A -RRB- in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells .
23226740	0	INK4A	41,46	p16	37,40	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter and histone methylation and p16 -LRB- INK4A -RRB- gene expression in colon_cancer .
25497382	0	INK4A	42,47	p16	38,41	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epigenetic regulation of p14 -LRB- ARF -RRB- and p16 -LRB- INK4A -RRB- expression in cutaneous_and_uveal_melanoma .
25575976	0	INK4A	40,45	p16	36,39	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	High-grade acute organ_toxicity and p16 -LRB- INK4A -RRB- expression as positive prognostic factors in primary radio -LRB- chemo -RRB- therapy for patients with head_and_neck_squamous_cell_carcinoma .
25688737	0	INK4A	45,50	p16	41,44	INK4A	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Frequency and prognostic significance of p16 -LRB- INK4A -RRB- protein overexpression and transcriptionally active human_papillomavirus_infection in laryngeal_squamous_cell_carcinoma .
25908244	0	INK4A	33,38	p16	29,32	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The lncRNA MIR31HG regulates p16 -LRB- INK4A -RRB- expression to modulate senescence .
26927017	0	INK4A	86,91	p16	82,85	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	LncRNA PANDAR regulates the G1/S transition of breast_cancer cells by suppressing p16 -LRB- INK4A -RRB- expression .
9788631	0	INK4A	25,30	p16	20,23	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inactivation of the p16 -LRB- INK4A -RRB- tumor-suppressor gene in pancreatic_duct_lesions : loss of intranuclear expression .
9815612	0	INK4A	24,29	p16	20,23	INK4A	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Characterization of p16 -LRB- INK4A -RRB- expression in multiple_myeloma and plasma_cell_leukemia .
9888465	0	INK4A	63,68	p16	46,49	INK4A	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA methylation in the promoter region of the p16 -LRB- CDKN2/MTS -1 / INK4A -RRB- gene in human breast_tumours .
12698196	0	INK4A	61,66	p18	69,72	INK4A	p18	1029	1031	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
12698196	0	INK4A	61,66	p19	81,84	INK4A	p19	1029	1032	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
11102889	0	INK4A	93,98	p21	101,104	INK4A	p21	1029	1026	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
12698196	0	INK4A	61,66	p21	93,96	INK4A	p21	1029	1026	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
16998811	0	INK4A	64,69	p21	83,86	INK4A	p21	1029	1026	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
16998811	0	INK4A	64,69	p27	72,75	INK4A	p27	1029	3429	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
11102889	0	INK4A	93,98	p53	84,87	INK4A	p53	1029	7157	Gene	Gene	p16|appos|START_ENTITY END_ENTITY|appos|p16	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
16998811	0	INK4A	64,69	p53	55,58	INK4A	p53	1029	7157	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
27076841	0	INK4A	27,32	p53	0,3	INK4A	p53	1029	7157	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	p53 expression but not p16 -LRB- INK4A -RRB- correlates with human_papillomavirus-associated esophageal_squamous_cell_carcinoma in Kazakh population .
9788631	0	INK4A	25,30	tumor-suppressor	32,48	INK4A	tumor-suppressor	1029	7248	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inactivation of the p16 -LRB- INK4A -RRB- tumor-suppressor gene in pancreatic_duct_lesions : loss of intranuclear expression .
14536079	0	INK4A-ARF	20,29	Bmi-1	0,5	INK4A-ARF	Bmi-1	1029	648	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1 .
11355949	0	INK4A-ARF	100,109	bmi-1	4,9	INK4A-ARF	bmi-1	1029	648	Gene	Gene	expression|compound|START_ENTITY expressed|nmod|expression expressed|nsubjpass|oncoprotein oncoprotein|amod|END_ENTITY	The bmi-1 oncoprotein is differentially expressed in non-small_cell_lung_cancer and correlates with INK4A-ARF locus expression .
10090949	0	INK4B	34,39	p15	30,33	INK4B	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Acquisition of p16 -LRB- INK4A -RRB- and p15 -LRB- INK4B -RRB- gene abnormalities between initial diagnosis and relapse in children with acute_lymphoblastic_leukemia .
10574984	0	INK4B	45,50	p15	41,44	INK4B	p15	1030	1030	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Transforming_growth_factor-beta-mediated p15 -LRB- INK4B -RRB- induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines .
10812241	0	INK4B	52,57	p15	48,51	INK4B	p15	1030	1030	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cyclin-dependent kinase inhibitor p15 -LRB- INK4B -RRB- during normal and leukemic myeloid differentiation .
11167795	0	INK4B	23,28	p15	19,22	INK4B	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylation of the p15 -LRB- INK4B -RRB- gene in myelodysplastic_syndrome : it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation .
12150726	0	INK4B	28,33	p15	24,27	INK4B	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hypermethylation of the p15 -LRB- INK4B -RRB- gene in acute_leukemia and myelodysplastic_syndromes .
12485524	0	INK4B	26,31	p15	22,25	INK4B	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The re-expression of p15 -LRB- INK4B -RRB- gene in leukemia cells induced by in vitro DNA methyltransferase and histone deacetylase inhibition -RSB- .
12578663	0	INK4B	29,34	p15	25,28	INK4B	p15	1030	1030	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	-LSB- Study on Methylation of p15 -LRB- INK4B -RRB- Gene in Acute Myeloid_Leukemia and Chronic_Myeloid_Leukemia -RSB- In order to explore the role of p15 -LRB- INK4B -RRB- gene with highly methylated CpG island in the pathogenesis of leukemia , the expression levels of p15 -LRB- INK4B -RRB- gene was detected in patients with AML and CML .
21544337	0	INK4B	35,40	p15	31,34	INK4B	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of RB , p16/CDKN2 and p15 -LRB- INK4B -RRB- gene alterations with immunohistochemical studies in human prostate_carcinomas .
8847892	0	INK4B	107,112	p15	103,106	INK4B	p15	1030	1030	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	A novel pre-B acute_lymphoblastic_leukemia cell line with chromosomal translocation between p16 -LRB- INK4A -RRB- / p15 -LRB- INK4B -RRB- tumor suppressor and immunoglobulin heavy chain genes : TGFbeta/IL -7 inhibitory signaling mechanism .
10556039	0	INK4C	91,96	INK4A	76,81	INK4C	INK4A	1031	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Tumor suppressor INK4 : comparisons of conformational properties between p16 -LRB- INK4A -RRB- and p18 -LRB- INK4C -RRB- .
12796810	0	INK4C	30,35	P18	26,29	INK4C	P18	1031	1031	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The effects of inhibiting P18 -LRB- INK4C -RRB- expression on the invasion of gastric_adenocarcinoma cell line .
15349907	0	INK4C	47,52	p18	43,46	INK4C	p18	1031	1031	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of cell cycle regulator p18 -LRB- INK4C -RRB- in human hepatocellular_carcinoma .
18642058	0	INK4C	45,50	p18	40,43	INK4C	p18	1031	1031	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sodium_butyrate-induced upregulation of p18 -LRB- INK4C -RRB- gene affects K562 cell G -LRB- 0 -RRB- / G -LRB- 1 -RRB- arrest and differentiation .
26350239	6	INK4C	798,803	p18	794,797	INK4C	p18	1031	1031	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Furthermore , we found that DNMT3A modulated p18 -LRB- INK4C -RRB- by directly binding to and silencing the p18 -LRB- INK4C -RRB- gene via promoter hypermethylation .
25872337	0	INK4a	29,34	COX-2	37,42	INK4a	COX-2	1029	4513	Gene	Gene	survivin|appos|START_ENTITY survivin|amod|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
25872337	0	INK4a	29,34	COX-2	37,42	INK4a	COX-2	1029	4513	Gene	Gene	survivin|appos|START_ENTITY survivin|amod|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
21263217	0	INK4a	19,24	CREG1	0,5	INK4a	CREG1	1029	8804	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	CREG1 enhances p16 -LRB- INK4a -RRB- - induced cellular senescence .
15138269	0	INK4a	42,47	Id1	63,66	INK4a	Id1	1029	3397	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulation of cellular senescence and p16 -LRB- INK4a -RRB- expression by Id1 and E47 proteins in human diploid fibroblast .
10398427	0	INK4a	12,17	P16	8,11	INK4a	P16	1029	1029	Gene	Gene	CDKN2A|appos|START_ENTITY CDKN2A|dep|END_ENTITY	CDKN2A -LRB- P16 -LRB- INK4a -RRB- -RRB- and CDK4 mutation analysis in 131 Australian melanoma probands : effect of family history and multiple primary melanomas .
16411180	0	INK4a	12,17	P16	8,11	INK4a	P16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Role of P16 -LRB- INK4a -RRB- expression in identifying CIN2 or more severe lesions among HPV-positive patients referred for colposcopy after abnormal cytology .
21211322	0	INK4a	19,24	P16	15,18	INK4a	P16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- Evaluation of P16 -LRB- INK4a -RRB- expression in Thinprep cervical specimens for the predication of high-grade cervical intraepithelial_neoplasia -RSB- .
26261680	0	INK4a	27,32	P16	23,26	INK4a	P16	1029	1029	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Comments on Bu et al. `` P16 -LRB- INK4a -RRB- overexpression and survival in osteosarcoma patients : a meta analysis '' .
16258956	0	INK4a	91,96	p15	99,102	INK4a	p15	1029	1030	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors -LSB- p16 -LRB- INK4a -RRB- , p15 -LRB- INK4b -RRB- , p14 -LRB- ARF -RRB- -RSB- in mantle_cell_lymphoma .
10469011	0	INK4a	5,10	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p16 -LRB- INK4a , MTS-1 -RRB- gene polymorphism and methylation status in human pituitary_tumours .
10694947	0	INK4a	34,39	p16	29,32	INK4a	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inactivation patterns of the p16 -LRB- INK4a -RRB- gene in oral_squamous_cell_carcinoma cell lines .
10856241	0	INK4a	72,77	p16	68,71	INK4a	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	JunB suppresses cell proliferation by transcriptional activation of p16 -LRB- INK4a -RRB- expression .
10861481	0	INK4a	95,100	p16	91,94	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Methylation of specific CpG sites in the promoter region could significantly down-regulate p16 -LRB- INK4a -RRB- expression in gastric_adenocarcinoma .
10942530	0	INK4a	31,36	p16	27,30	INK4a	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of p16 -LRB- INK4a -RRB- in azoxymethane-induced mouse colon_tumorigenesis .
11025365	8	INK4a	1014,1019	p16	1010,1013	INK4a	p16	1029	1029	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	None_of_the_insulinomas carried intragenic p16 -LRB- INK4a -RRB- mutations .
11040180	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p16 -LRB- INK4a -RRB- expression begins early in human colon_neoplasia and correlates inversely with markers of cell proliferation .
11241308	0	INK4a	12,17	p16	8,11	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of p16 -LRB- INK4a -RRB- expression correlates with decreased survival in pediatric_osteosarcomas .
11281650	0	INK4a	150,155	p16	146,149	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16 -LRB- INK4a -RRB- expression .
11282486	0	INK4a	38,43	p16	34,37	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Correlation between p21 -LRB- waf1 -RRB- and p16 -LRB- INK4a -RRB- expression in hepatocellular_carcinoma .
11485924	0	INK4a	54,59	p16	50,53	INK4a	p16	1029	1029	Gene	Gene	CDKN2A|appos|START_ENTITY CDKN2A|dep|END_ENTITY	Alterations of the tumor suppressor genes CDKN2A -LRB- p16 -LRB- INK4a -RRB- -RRB- , p14 -LRB- ARF -RRB- , CDKN2B -LRB- p15 -LRB- INK4b -RRB- -RRB- , and CDKN2C -LRB- p18 -LRB- INK4c -RRB- -RRB- in atypical and anaplastic_meningiomas .
11706079	0	INK4a	198,203	p16	194,197	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical -LSB- corrected -RSB- detection of the alternate INK4a-encoded tumor suppressor protein p14 -LRB- ARF -RRB- in archival human cancers and cell lines using commercial antibodies : correlation with p16 -LRB- INK4a -RRB- expression .
11859122	0	INK4a	33,38	p16	29,32	INK4a	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	cyclin-dependent|appos|START_ENTITY cyclin-dependent|amod|END_ENTITY	Transgenic expression of the p16 -LRB- INK4a -RRB- cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8 - immature thymocytes .
12170463	0	INK4a	30,35	p16	26,29	INK4a	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	-LSB- Conditional targeting of p16 -LRB- INK4a -RRB- exon 1a in mouse embryonic stem cells -RSB- .
12538475	0	INK4a	49,54	p16	45,48	INK4a	p16	1029	1029	Gene	Gene	CDKN2A|appos|START_ENTITY CDKN2A|dep|END_ENTITY	Detecting homozygous_deletions in the CDKN2A -LRB- p16 -LRB- INK4a -RRB- -RRB- / ARF -LRB- p14 -LRB- ARF -RRB- -RRB- gene in urinary_bladder_cancer using real-time quantitative PCR .
15138269	0	INK4a	42,47	p16	38,41	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of cellular senescence and p16 -LRB- INK4a -RRB- expression by Id1 and E47 proteins in human diploid fibroblast .
15260845	0	INK4a	53,58	p16	49,52	INK4a	p16	1029	1029	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Aberrant methylation of p14 -LRB- ARF -RRB- , p15 -LRB- INK4b -RRB- and p16 -LRB- INK4a -RRB- genes and location of the primary site in pulmonary_squamous_cell_carcinoma .
15870532	0	INK4a	39,44	p16	35,38	INK4a	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Human_papillomavirus infection and p16 -LRB- INK4a -RRB- protein expression in vulvar_intraepithelial_neoplasia and invasive squamous_cell_carcinoma .
15892997	0	INK4a	66,71	p16	62,65	INK4a	p16	1029	1029	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Expression of the p16 -LRB- INK4a -RRB- gene product , methylation of the p16 -LRB- INK4a -RRB- promoter region and expression of the polycomb-group gene BMI-1 in squamous_cell_lung_carcinoma and premalignant_endobronchial_lesions .
16647956	0	INK4a	118,123	p16	114,117	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p16 -LRB- INK4a -RRB- promoter methylation and 9p21 allelic loss in colorectal_carcinomas : relation with immunohistochemical p16 -LRB- INK4a -RRB- expression and with tumor budding .
16647956	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	p16 -LRB- INK4a -RRB- promoter methylation and 9p21 allelic loss in colorectal_carcinomas : relation with immunohistochemical p16 -LRB- INK4a -RRB- expression and with tumor budding .
16767161	0	INK4a	23,28	p16	19,22	INK4a	p16	1029	1029	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Methylation of the p16 -LRB- INK4a -RRB- promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells .
16820088	0	INK4a	38,43	p16	34,37	INK4a	p16	1029	1029	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of the tumor-suppressor p16 -LRB- INK4a -RRB- within regenerative epithelial crypts in ulcerative_colitis .
16828922	0	INK4a	55,60	p16	51,54	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The reduced expression and aberrant methylation of p16 -LRB- INK4a -RRB- in chromate workers with lung_cancer .
16973350	0	INK4a	18,23	p16	14,17	INK4a	p16	1029	1029	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of p16 -LRB- INK4a -RRB- in relation to histopathology and viral load of ` high-risk ' HPV types in cervical neoplastic_lesions .
17046239	0	INK4a	36,41	p16	32,35	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	An immunohistochemical study of p16 -LRB- INK4a -RRB- expression in multistep thyroid tumourigenesis .
17152048	0	INK4a	18,23	p16	14,17	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Comparison of p16 -LRB- INK4a -RRB- expression with p53 alterations in head_and_neck_cancer by tissue microarray analysis .
17192788	0	INK4a	128,133	p16	124,127	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	IMP3 is a novel biomarker for adenocarcinoma_in_situ of the uterine cervix : an immunohistochemical study in comparison with p16 -LRB- INK4a -RRB- expression .
17367324	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	Expression|appos|START_ENTITY Expression|amod|END_ENTITY	p16 -LRB- INK4a -RRB- Expression does not predict the outcome of cervical_intraepithelial_neoplasia_grade_2 .
17459456	0	INK4a	28,33	p16	24,27	INK4a	p16	1029	1029	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	A common variant of the p16 -LRB- INK4a -RRB- genetic region is associated with physical function in older people .
17906698	0	INK4a	25,30	p16	21,24	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	P300 plays a role in p16 -LRB- INK4a -RRB- expression and cell cycle arrest .
17989730	0	INK4a	85,90	p16	81,84	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Premature senescence of balding dermal papilla cells in vitro is associated with p16 -LRB- INK4a -RRB- expression .
18365017	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	translation|appos|START_ENTITY translation|amod|END_ENTITY	p16 -LRB- INK4a -RRB- translation suppressed by miR-24 .
18692948	0	INK4a	50,55	p16	46,49	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Classical and non-classical HLA molecules and p16 -LRB- INK4a -RRB- expression in precursors lesions and invasive_cervical_cancer .
19100258	0	INK4a	73,78	p16	69,72	INK4a	p16	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transition_of_cervical_carcinoma in situ to invasive_cancer : role of p16 INK4a expression in progression and in recurrence .
19196247	0	INK4a	20,25	p16	16,19	INK4a	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Aging increases p16 INK4a expression in vascular smooth-muscle cells .
19450526	0	INK4a	32,37	p16	28,31	INK4a	p16	1029	1029	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Epigenetic silencing of the p16 -LRB- INK4a -RRB- tumor suppressor is associated with loss of CTCF binding and a chromatin boundary .
19656618	0	INK4a	92,97	p16	88,91	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hepatitis_B_virus X protein overcomes stress-induced premature senescence by repressing p16 -LRB- INK4a -RRB- expression via DNA methylation .
19683687	0	INK4a	13,18	p16	9,12	INK4a	p16	1029	1029	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	Value of p16 -LRB- INK4a -RRB- as a marker of progression/regression in cervical_intraepithelial_neoplasia_grade_1 .
20340136	0	INK4a	60,65	p16	56,59	INK4a	p16	1029	1029	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Predicting functional significance of cancer-associated p16 -LRB- INK4a -RRB- mutations in CDKN2A .
21035853	0	INK4a	31,36	p16	27,30	INK4a	p16	1029	1029	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Quantitative evaluation of p16 -LRB- INK4a -RRB- promoter methylation using pyrosequencing in de novo diffuse_large_B-cell_lymphoma .
21225495	0	INK4a	34,39	p16	29,32	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	High-risk HPV DNA status and p16 -LRB- INK4a -RRB- expression as prognostic markers in patients with squamous_cell_cancer_of_oral_cavity and oropharynx .
21390332	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	suppression|appos|START_ENTITY suppression|amod|END_ENTITY	p16 -LRB- INK4a -RRB- suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms .
21657082	0	INK4a	136,141	p16	132,135	INK4a	p16	1029	1029	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Experimental study of relationship between effect of ginsenoside_Rg1 to delay hematopoietic stem cell senescence and expression of p16 -LRB- INK4a -RRB- -RSB- .
21920875	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p16 -LRB- INK4a -RRB- expression and breast_cancer risk in women with atypical_hyperplasia .
21990227	0	INK4a	19,24	p16	15,18	INK4a	p16	1029	1029	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of p16 -LRB- INK4a -RRB- overexpression with improved outcomes in young patients with squamous_cell_cancers of the oral tongue .
22395468	0	INK4a	89,94	p16	84,87	INK4a	p16	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Histone_deacetylase_3 -LRB- HDAC3 -RRB- participates in the transcriptional repression of the p16 -LRB- INK4a -RRB- gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet .
22419364	0	INK4a	13,18	p16	9,12	INK4a	p16	1029	1029	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	Value of p16 -LRB- INK4a -RRB- in the diagnosis of low-grade urothelial_carcinoma of the urinary_bladder in urinary cytology .
22489695	0	INK4a	194,199	p16	190,193	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal_squamous_cell_carcinoma , with emphasis on smoking , protein p16 -LRB- INK4a -RRB- expression , and HPV status .
22738669	0	INK4a	18,23	p16	14,17	INK4a	p16	1029	1029	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of p16 -LRB- INK4a -RRB- as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy .
22850945	0	INK4a	21,26	p16	17,20	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	An evaluation of p16 -LRB- INK4a -RRB- expression in cervical_intraepithelial_neoplasia specimens , including women with HIV-1 .
22863066	0	INK4a	152,157	p16	148,151	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Identification and genotyping of human_papillomavirus in a Spanish cohort of penile_squamous_cell_carcinomas : correlation with pathologic subtypes , p16 -LRB- INK4a -RRB- expression , and prognosis .
23443045	0	INK4a	19,24	p16	15,18	INK4a	p16	1029	1029	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	FOXA1 mediates p16 -LRB- INK4a -RRB- activation during cellular senescence .
24421848	0	INK4a	75,80	p16	71,74	INK4a	p16	1029	1029	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Primary_Squamous_Cell_Carcinoma of the Upper Genital Tract : Utility of p16 -LRB- INK4a -RRB- Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical_Squamous_Cell_Carcinoma .
24760498	0	INK4a	24,29	p16	20,23	INK4a	p16	1029	1029	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of protein p16 -LRB- INK4a -RRB- in glottic laryngeal_squamous_cell_carcinoma .
24837742	0	INK4a	58,63	p16	54,57	INK4a	p16	1029	1029	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Methylation of CpG island of p14 -LRB- ARK -RRB- , p15 -LRB- INK4b -RRB- and p16 -LRB- INK4a -RRB- genes in coke oven workers .
24839133	0	INK4a	38,43	p16	34,37	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human_papillomavirus DNA load and p16 -LRB- INK4a -RRB- expression predict for local control in patients with anal_squamous_cell_carcinoma treated with chemoradiotherapy .
24908414	0	INK4a	54,59	p16	49,52	INK4a	p16	1029	1029	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Aberrant promoter methylation of p15 -LRB- INK4b -RRB- and p16 -LRB- INK4a -RRB- genes may contribute to the pathogenesis of multiple_myeloma : a meta-analysis .
24937448	0	INK4a	173,178	p16	169,172	INK4a	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16 -LRB- INK4a -RRB- gene in human colorectal_carcinoma -LRB- Caco-2 -RRB- cells .
25257576	0	INK4a	161,166	p16	157,160	INK4a	p16	1029	1029	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	No evidence of oncogenic KRAS mutations in squamous_cell_carcinomas of the anogenital tract and head and neck region independent of human_papillomavirus and p16 -LRB- INK4a -RRB- status .
25499675	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	p16 INK4a expression in retinoblastoma : a marker of differentiation grade .
25542698	0	INK4a	59,64	p16	55,58	INK4a	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Quantitative analysis of CDKN2A methylation , mRNA , and p16 -LRB- INK4a -RRB- protein expression in children and adolescents with Burkitt_lymphoma : Biological and clinical implications .
25885064	0	INK4a	36,41	p16	32,35	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The role of histologic subtype , p16 -LRB- INK4a -RRB- expression , and presence of human_papillomavirus DNA in penile_squamous_cell_carcinoma .
25923845	0	INK4a	20,25	p16	16,19	INK4a	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Ablation of the p16 -LRB- INK4a -RRB- tumour suppressor reverses ageing phenotypes of klotho mice .
26268412	0	INK4a	98,103	p16	94,97	INK4a	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	-LSB- The natural history of cervical_intraepithelial_neoplasia_I and the clinical significance of p16 -LRB- INK4a -RRB- protein as a marker of progression in cervical_intraepithelial_neoplasia_I -RSB- .
26622834	0	INK4a	69,74	p16	65,68	INK4a	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Effect of phosphorylation and methylation on the function of the p16 -LRB- INK4a -RRB- protein in non-small_cell_lung_cancer A549 cells .
26731175	0	INK4a	96,101	p16	92,95	INK4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16 -LRB- INK4a -RRB- expression in subjects on combination therapy .
26835415	0	INK4a	127,132	p16	122,125	INK4a	p16	1029	1029	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	The rs11515 Polymorphism Is More Frequent and Associated With Aggressive_Breast_Tumors with Increased ANRIL and Decreased p16 -LRB- INK4a -RRB- Expression .
26940728	0	INK4a	100,105	p16	96,99	INK4a	p16	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16 -LRB- INK4a -RRB- expression in head_and_neck_squamous_cell_carcinoma patients .
9531609	0	INK4a	4,9	p16	0,3	INK4a	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p16 -LRB- INK4a -RRB- gene inactivation by deletions , mutations , and hypermethylation is associated with transformed and aggressive_variants_of_non-Hodgkin 's _ lymphomas .
20683015	0	INK4a	42,47	p27	14,17	INK4a	p27	1029	3429	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of p27 , p21 -LRB- WAF/Cip1 -RRB- , and p16 -LRB- INK4a -RRB- in normal oral epithelium , oral_squamous_papilloma , and oral_squamous_cell_carcinoma .
10922393	0	INK4a	24,29	p53	46,49	INK4a	p53	1029	7157	Gene	Gene	Absence|appos|START_ENTITY alterations|nsubj|Absence alterations|nmod|families families|nummod|END_ENTITY	Absence of germline p16 -LRB- INK4a -RRB- alterations in p53 wild type Li-Fraumeni_syndrome families .
10986054	0	INK4a	32,37	p53	66,69	INK4a	p53	1029	7157	Gene	Gene	START_ENTITY|dep|hypermethylation hypermethylation|appos|mutation mutation|compound|END_ENTITY	Differential frequencies of p16 -LRB- INK4a -RRB- promoter hypermethylation , p53 mutation , and K-ras mutation in exfoliative material mark the development of lung_cancer in symptomatic chronic smokers .
11313791	0	INK4a	44,49	p53	32,35	INK4a	p53	1029	7157	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|END_ENTITY	Adenovirus-mediated transfer of p53 and p16 -LRB- INK4a -RRB- results in pancreatic_cancer regression in vitro and in vivo .
11777345	0	INK4a	33,38	p53	23,26	INK4a	p53	1029	7157	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Expression profiles of p53 - , p16 -LRB- INK4a -RRB- - , and telomere-regulating genes in replicative senescent primary human , mouse , and chicken fibroblast cells .
17152048	0	INK4a	18,23	p53	41,44	INK4a	p53	1029	7157	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Comparison of p16 -LRB- INK4a -RRB- expression with p53 alterations in head_and_neck_cancer by tissue microarray analysis .
19069712	0	INK4a	67,72	p53	55,58	INK4a	p53	1029	7157	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	-LSB- Histopathological characteristics and coexpression of p53 and p16 -LRB- INK4a -RRB- proteins in renal_cancer -RSB- .
25410620	0	INK4a	123,128	p53	111,114	INK4a	p53	25163(Tax:10116)	301300(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down-regulation of p53 and p16 -LRB- INK4a -RRB- genes in rat liver .
15257544	0	INK4a	18,23	pRb	122,125	INK4a	pRb	1029	5925	Gene	Gene	START_ENTITY|nmod|status status|compound|END_ENTITY	Profiles of the 2 INK4a gene products , p16 and p14ARF , in human reference urothelium and bladder_carcinomas , according to pRb and p53 protein status .
11418489	0	INK4b	19,24	p15	15,18	INK4b	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p16 -LRB- INK4a -RRB- and p15 -LRB- INK4b -RRB- gene methylations in plasma cells from monoclonal_gammopathy of undetermined significance .
11445839	0	INK4b	39,44	p15	35,38	INK4b	p15	1030	1030	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Hypermethylation of p16 -LRB- INK4a -RRB- and p15 -LRB- INK4b -RRB- genes in non-small cell lung_cancer .
12513775	0	INK4b	20,25	p15	16,19	INK4b	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Abnormality of p15 -LRB- INK4b -RRB- gene and myelodysplastic_syndrome -RSB- .
12750706	0	INK4b	115,120	p15	111,114	INK4b	p15	1030	1030	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hypermethylation of GpG islands in the promoter region of p15 -LRB- INK4b -RRB- in acute_promyelocytic_leukemia represses p15 -LRB- INK4b -RRB- expression and correlates with poor prognosis .
15474025	0	INK4b	70,75	p15	66,69	INK4b	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15 -LRB- INK4b -RRB- gene .
17316622	0	INK4b	63,68	p15	59,62	INK4b	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Oct-1 is involved in the transcriptional repression of the p15 -LRB- INK4b -RRB- gene .
22783444	0	INK4b	19,24	p15	15,18	INK4b	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p16 -LRB- INK4a -RRB- and p15 -LRB- INK4b -RRB- gene promoter methylation in cervical_cancer patients .
9033652	0	INK4b	61,66	p15	57,60	INK4b	p15	1030	1030	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Multiple types of aberrations in the p16 -LRB- INK4a -RRB- and the p15 -LRB- INK4b -RRB- genes in 30 esophageal squamous-cell-carcinoma cell lines .
9531610	0	INK4b	23,28	p15	19,22	INK4b	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylation of the p15 -LRB- INK4b -RRB- gene in myelodysplastic_syndromes is frequent and acquired during disease progression .
11544316	0	INK4c	39,44	p18	35,38	INK4c	p18	12580(Tax:10090)	12580(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	An important role of CDK inhibitor p18 -LRB- INK4c -RRB- in modulating antigen receptor-mediated T cell proliferation .
11255035	0	INK4d	139,144	p19	135,138	INK4d	p19	1032	1032	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Retroviral manipulation of the expression of bone morphogenetic protein receptor Ia by SVZa progenitor cells leads to changes in their p19 -LRB- INK4d -RRB- expression but not in their neuronal commitment .
12062451	0	INK4d	56,61	p19	52,55	INK4d	p19	1032	1032	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning and characterization of the human p19 -LRB- INK4d -RRB- gene promoter .
12941628	0	INK4d	89,94	p19	85,88	INK4d	p19	12581(Tax:10090)	12581(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19 -LRB- INK4d -RRB- expression during odontogenesis .
17873901	0	INK4d	55,60	p19	51,54	INK4d	p19	12581(Tax:10090)	12581(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	FOXO transcription factor-dependent p15 -LRB- INK4b -RRB- and p19 -LRB- INK4d -RRB- expression .
19331820	0	INMAP	39,44	interphase_nucleus_and_mitotic_apparatus	54,94	INMAP	interphase nucleus and mitotic apparatus	55703	55703	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification and characterization of INMAP , a novel interphase_nucleus_and_mitotic_apparatus protein that is involved in spindle formation and cell cycle progression .
3025587	0	INO1	74,78	inositol-1-phosphate_synthase	43,72	INO1	inositol-1-phosphate synthase	853288(Tax:4932)	853288(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the Saccharomyces_cerevisiae inositol-1-phosphate_synthase -LRB- INO1 -RRB- gene is regulated by factors that affect phospholipid synthesis .
24152841	0	INOS	38,42	HO-1	33,37	INOS	HO-1	4843	3162	Gene	Gene	interaction|dep|START_ENTITY interaction|nmod|END_ENTITY	Negative feedback interaction of HO-1 / INOS in PBMC of acute congestive heart_failure patients .
10780272	0	INPP1	94,99	inositol_polyphosphate_1-phosphatase	51,87	INPP1	inositol polyphosphate 1-phosphatase	3628	3628	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and sequence analysis of a human inositol_polyphosphate_1-phosphatase gene -LRB- INPP1 -RRB- .
25395580	0	INPP5E	0,6	AURKA	22,27	INPP5E	AURKA	56623	6790	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	INPP5E interacts with AURKA , linking phosphoinositide signalling to primary cilium stability .
26490104	0	INPP5E	23,29	MKS1	0,4	INPP5E	MKS1	56623	54903	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	MKS1 regulates ciliary INPP5E levels in Joubert_syndrome .
19668216	0	INPP5E	13,19	inositol_polyphosphate-5-phosphatase_E	30,68	INPP5E	inositol polyphosphate-5-phosphatase E	56623	56623	Gene	Gene	Mutations|nmod|START_ENTITY Mutations|amod|END_ENTITY	Mutations in INPP5E , encoding inositol_polyphosphate-5-phosphatase_E , link phosphatidyl_inositol signaling to the ciliopathies .
20644547	0	INS-1	125,130	AMPK	0,4	PDX-1	AMPK	29535(Tax:10116)	78975(Tax:10116)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	AMPK enhances the expression of pancreatic_duodenal_homeobox-1 via PPARalpha , but not PPARgamma , in rat_insulinoma cell line INS-1 .
24625528	0	INS-1	74,79	AMPK	54,58	INS-1	AMPK	2305	5562	Gene	Gene	pancreatic|amod|START_ENTITY beta-cells|amod|pancreatic b1|nmod|beta-cells _|dep|b1 analysis|dep|_ analysis|nmod|AMP-activated_protein_kinase AMP-activated_protein_kinase|appos|END_ENTITY	Interactome analysis of AMP-activated_protein_kinase -LRB- AMPK -RRB- - a1_and _ - b1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry .
16547599	0	INS-1	73,78	Ccnd1	20,25	INS-1	Ccnd1	24505(Tax:10116)	58919(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Upregulation of rat Ccnd1 gene by exendin-4 in pancreatic beta cell line INS-1 : interaction of early growth response-1 with cis-regulatory element .
11145745	0	INS-1	73,78	Growth_hormone	0,14	INS-1	Growth hormone	2305	2688	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Growth_hormone - and prolactin-induced proliferation_of_insulinoma cells , INS-1 , depends on activation of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- .
10909970	0	INS-1	58,63	IA-2	50,54	INS-1	IA-2	2305	5798	Gene	Gene	pancreatic|amod|START_ENTITY beta-cells|amod|pancreatic Regulation|nmod|beta-cells Regulation|nmod|END_ENTITY	Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells .
12239095	0	INS-1	102,107	IA-2	94,98	INS-1	IA-2	24505(Tax:10116)	116660(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Effect of proinflammatory cytokines on gene expression of the diabetes-associated autoantigen IA-2 in INS-1 cells .
14604813	0	INS-1	54,59	IRS-2	11,16	INS-1	IRS-2	2305	8660	Gene	Gene	beta-cells|appos|START_ENTITY expression|nmod|beta-cells expression|compound|END_ENTITY	Decreasing IRS-2 expression in pancreatic beta-cells -LRB- INS-1 -RRB- promotes apoptosis , which can be compensated for by introduction of IRS-4 expression .
15269981	0	INS-1	49,54	IRS-2	15,20	INS-1	IRS-2	24505(Tax:10116)	29376(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells Impairment|acl|signaling Impairment|nmod|END_ENTITY	-LSB- Impairment of IRS-2 signaling in rat insulinoma INS-1 cells by nelfinavir -RSB- .
26919700	0	INS-1	69,74	IRS-2	60,65	INS-1	IRS-2	2305	8660	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 b Cells .
18082128	0	INS-1	109,114	Insulin	52,59	INS-1	Insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY composition|nmod|cells alter|dobj|composition alter|nsubj|secretagogues secretagogues|compound|END_ENTITY	The role of rapid lipogenesis in insulin secretion : Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells .
21076579	0	INS-1	92,97	Insulin	65,72	INS-1	Insulin	2305	3630	Gene	Gene	Cells|compound|START_ENTITY Effect|nmod|Cells Effect|nmod|Tribbles-Related_Protein_3 Tribbles-Related_Protein_3|nmod|Expression Expression|compound|END_ENTITY	The Effect of Tribbles-Related_Protein_3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells .
25310693	0	INS-1	64,69	Insulin	27,34	INS-1	Insulin	2305	3630	Gene	Gene	Beta-Cells|compound|START_ENTITY Dependence|nmod|Beta-Cells Dependence|nmod|Dynamics Dynamics|compound|END_ENTITY	Cytoskeletal Dependence of Insulin Granule Movement Dynamics in INS-1 Beta-Cells in Response to Glucose .
26986474	0	INS-1	83,88	Insulin	62,69	INS-1	Insulin	2305	3630	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|compound|END_ENTITY	Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells .
21537415	0	INS-1	106,111	Pancreatic_and_Duodenal_Homeobox_1	68,102	INS-1	Pancreatic and Duodenal Homeobox 1	24505(Tax:10116)	29535(Tax:10116)	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic_and_Duodenal_Homeobox_1 in INS-1 Cells Exposed to High Glucose and Palmitate .
19479076	0	INS-1	38,43	ZnT8	19,23	INS-1	ZnT8	24505(Tax:10116)	299903(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion .
10512366	0	INS-1	113,118	c-fos	63,68	INS-1	c-fos	24505(Tax:10116)	314322(Tax:10116)	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1 .
11845326	0	INS-1	59,64	glucagon-like_peptide-1_receptor	23,55	INS-1	glucagon-like peptide-1 receptor	24505(Tax:10116)	25051(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Over-expression of the glucagon-like_peptide-1_receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity : a strategy for production of pancreatic beta-cell lines for use in transplantation .
12054498	0	INS-1	59,64	insulin	38,45	INS-1	insulin	2305	3630	Gene	Gene	lines|amod|START_ENTITY secretion|nmod|lines secretion|compound|END_ENTITY	Extracellular acidification parallels insulin secretion in INS-1 and HIT-T15 beta-cell lines .
15650027	0	INS-1	68,73	insulin	34,41	INS-1	insulin	2305	3630	Gene	Gene	pancreatic|amod|START_ENTITY beta-cells|amod|pancreatic attenuates|nmod|beta-cells attenuates|dobj|activity activity|compound|END_ENTITY	Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element .
15756539	0	INS-1	95,100	insulin	53,60	INS-1	insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY signalling|nmod|cells secretion|acl|signalling secretion|compound|END_ENTITY	Suppression of Pdx-1 perturbs proinsulin processing , insulin secretion and GLP-1 signalling in INS-1 cells .
17686476	0	INS-1	80,85	insulin	40,47	INS-1	insulin	2305	3630	Gene	Gene	beta-cells|appos|START_ENTITY secretion|nmod|beta-cells secretion|nsubj|3H-serotonin 3H-serotonin|nmod|marker marker|nmod|END_ENTITY	3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells -LRB- INS-1 -RRB- .
18082128	0	INS-1	109,114	insulin	33,40	INS-1	insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY composition|nmod|cells alter|dobj|composition role|parataxis|alter role|nmod|secretion secretion|compound|END_ENTITY	The role of rapid lipogenesis in insulin secretion : Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells .
18562674	0	INS-1	80,85	insulin	59,66	INS-1	insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	CaV1 .2 rather than CaV1 .3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells .
22008547	0	INS-1	30,35	insulin	9,16	INS-1	insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb 's cycle flux independent of ATP synthesis .
26942217	0	INS-1	99,104	insulin	77,84	INS-1	insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY granules|nmod|cells granules|nsubj|method method|nmod|enrichment enrichment|nmod|END_ENTITY	An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells .
8662272	0	INS-1	121,126	insulin	100,107	INS-1	insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY accompanied|nmod|cells accompanied|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Adrenaline - , not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells .
8958215	0	INS-1	120,125	insulin	19,26	INS-1	insulin	2305	3630	Gene	Gene	cells|compound|START_ENTITY +|nmod|cells +|nsubj|correlates correlates|compound|END_ENTITY	Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2 + in aequorin-expressing INS-1 cells .
9482663	0	INS-1	41,46	insulin	52,59	INS-1	insulin	2305	3630	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity .
24798654	0	INS-1	60,65	neutral_ceramidase	26,44	INS-1	neutral ceramidase	24505(Tax:10116)	114104(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Low-dose cytokine-induced neutral_ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect .
9268630	0	INSIG1	86,92	CL-6	81,85	INSIG1	CL-6	3638	3638	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Cloning , human chromosomal assignment , and adipose and hepatic expression of the CL-6 / INSIG1 gene .
20145255	0	INSIG2	54,60	insulin-induced_gene_2	30,52	INSIG2	insulin-induced gene 2	51141	51141	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Characterization of the human insulin-induced_gene_2 -LRB- INSIG2 -RRB- promoter : the role of Ets-binding motifs .
23729566	0	INSL3	48,53	insulin-like_peptide_3	24,46	INSL3	insulin-like peptide 3	100861214	100861214	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	The active form of goat insulin-like_peptide_3 -LRB- INSL3 -RRB- is a single-chain structure comprising three domains B-C-A , constitutively expressed and secreted by testicular Leydig cells .
23934571	0	INSL3	48,53	insulin-like_peptide_3	24,46	INSL3	insulin-like peptide 3	100861214	100861214	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	The active form of goat insulin-like_peptide_3 -LRB- INSL3 -RRB- is a single-chain structure comprising three domains B-C-A , constitutively expressed and secreted by testicular Leydig cells .
11061561	0	INSL4	63,68	insulin-like_4	47,61	INSL4	insulin-like 4	3641	3641	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of pro-EPIL peptides encoded by the insulin-like_4 -LRB- INSL4 -RRB- gene in chromosomally abnormal pregnancies .
9284764	0	INSL4	77,82	insulin-like_4	61,75	INSL4	insulin-like 4	3641	3641	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Identification of pro-EPIL and EPIL peptides translated from insulin-like_4 -LRB- INSL4 -RRB- mRNA in human placenta .
14522968	0	INSL7	28,33	GPCR135	100,107	INSL7	GPCR135	117579	51289	Gene	Gene	Identification|nmod|START_ENTITY ligand|nsubj|Identification ligand|nmod|END_ENTITY	Identification of relaxin-3 / INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135 .
21072619	0	INSL7	10,15	Relaxin-3	0,9	INSL7	Relaxin-3	266997(Tax:10116)	266997(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Relaxin-3 / INSL7 regulates the stress-response system in the rat hypothalamus .
14522967	0	INSL7	28,33	relaxin-3	18,27	INSL7	relaxin-3	117579	117579	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of relaxin-3 / INSL7 as a ligand for GPCR142 .
17870193	0	INSL7	66,71	relaxin_3	56,65	INSL7	relaxin 3	266997(Tax:10116)	266997(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Developmental expression and serotonergic regulation of relaxin_3 / INSL7 in the nucleus incertus of rat brain .
17545194	0	INSR	68,72	NQO1	80,84	INSR	NQO1	3643	1728	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Cross-species microarray analysis with the OSCAR system suggests an INSR - > Pax6 - > NQO1 neuro-protective pathway in aging and Alzheimer 's _ disease .
17545194	0	INSR	68,72	Pax6	74,78	INSR	Pax6	3643	5080	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Cross-species microarray analysis with the OSCAR system suggests an INSR - > Pax6 - > NQO1 neuro-protective pathway in aging and Alzheimer 's _ disease .
19387820	0	INSR	54,58	SERPINE1	60,68	INSR	SERPINE1	3643	5054	Gene	Gene	polymorphisms|nmod|START_ENTITY END_ENTITY|nsubj|polymorphisms	Genetic polymorphisms of FSHR , CYP17 , CYP1A1 , CAPN10 , INSR , SERPINE1 genes in adolescent girls with polycystic_ovary_syndrome .
7697605	0	INT-2	57,62	c-erbB-2	13,21	INT-2	c-erbB-2	2248	2064	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Detection of c-erbB-2 / neu and fibroblast_growth_factor-3 / INT-2 but not epidermal_growth_factor_receptor gene amplification in endometrial_cancer by differential polymerase chain reaction .
17310990	0	INT6	6,10	MCM7	26,30	INT6	MCM7	3646	4176	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle .
25686840	0	INTS6	46,51	INTS6P1	11,18	INTS6	INTS6P1	26512	285634	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular_carcinoma .
25686840	0	INTS6P1	11,18	INTS6	46,51	INTS6P1	INTS6	285634	26512	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular_carcinoma .
18218308	0	INVS	15,19	NPHP2	21,26	INVS	NPHP2	27130	27130	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Association of INVS -LRB- NPHP2 -RRB- mutation in an adolescent exhibiting nephronophthisis -LRB- NPH -RRB- and complete situs inversus .
12360409	0	INrf2	100,105	Nrf2	0,4	INrf2	Nrf2	9817	4780	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|degradation degradation|amod|END_ENTITY	Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132 , the human homolog to INrf2 .
12947090	0	INrf2	115,120	Nrf2	105,109	INrf2	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	leads|nmod|START_ENTITY leads|nmod|release release|nmod|END_ENTITY	Phosphorylation of Nrf2 at Ser40 by protein_kinase_C in response to antioxidants leads to the release of Nrf2 from INrf2 , but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD -LRB- P -RRB- H : quinone_oxidoreductase-1 gene expression .
12947090	0	INrf2	115,120	Nrf2	19,23	INrf2	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	leads|nmod|START_ENTITY leads|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Nrf2 at Ser40 by protein_kinase_C in response to antioxidants leads to the release of Nrf2 from INrf2 , but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD -LRB- P -RRB- H : quinone_oxidoreductase-1 gene expression .
19666107	0	INrf2	5,10	Nrf2	0,4	INrf2	Nrf2	9817	4780	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Nrf2 : INrf2 -LRB- Keap1 -RRB- signaling in oxidative stress .
19920073	0	INrf2	36,41	Nrf2	177,181	INrf2	Nrf2	9817	4780	Gene	Gene	151|amod|START_ENTITY modification|nmod|151 required|nsubjpass|modification required|nmod|translocation translocation|nmod|END_ENTITY	Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance .
20864537	0	INrf2	23,28	Nrf2	60,64	INrf2	Nrf2	9817	4780	Gene	Gene	interaction|nmod|START_ENTITY mediates|nsubj|interaction mediates|dobj|activation activation|amod|END_ENTITY	Hsp90 interaction with INrf2 -LRB- Keap1 -RRB- mediates stress-induced Nrf2 activation .
22072718	0	INrf2	19,24	Nrf2	13,17	INrf2	Nrf2	9817	4780	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Inhibitor of Nrf2 -LRB- INrf2 or Keap1 -RRB- protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis .
22448038	0	INrf2	20,25	Nrf2	153,157	INrf2	Nrf2	9817	4780	Gene	Gene	tyrosine|nsubj|START_ENTITY tyrosine|ccomp|controls controls|xcomp|allow allow|dobj|activation activation|amod|END_ENTITY	Antioxidant-induced INrf2 -LRB- Keap1 -RRB- tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression .
25108015	0	INrf2	19,24	Nrf2	13,17	INrf2	Nrf2	9817	4780	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Inhibitor of Nrf2 -LRB- INrf2 or Keap1 -RRB- protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis .
25976679	0	INrf2	47,52	Nrf2	80,84	INrf2	Nrf2	9817	4780	Gene	Gene	Downregulation|nmod|START_ENTITY Leads|nsubj|Downregulation Leads|nmod|END_ENTITY	Aromatase Inhibitor-Mediated Downregulation of INrf2 -LRB- Keap1 -RRB- Leads to Increased Nrf2 and Resistance in Breast_Cancer .
1437149	0	IP-1	29,33	AP-1	0,4	IP-1	AP-1	8517	16476(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	AP-1 -LRB- Fos-Jun -RRB- regulation by IP-1 : effect of signal transduction pathways and cell growth .
18095157	0	IP-10	36,41	APP	70,73	IP-10	APP	15945(Tax:10090)	11820(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Decreased fractalkine and increased IP-10 expression in aged brain of APP -LRB- swe -RRB- transgenic_mice .
18716376	0	IP-10	39,44	Angiotensin_II	0,14	IP-10	Angiotensin II	3627	183	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases expression of IP-10 and the renin-angiotensin system in endothelial cells .
18811584	0	IP-10	118,123	CCL27	111,116	IP-10	CCL27	3627	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IP-10	118,123	CCR4	125,129	IP-10	CCR4	3627	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IP-10	118,123	CCR5	131,135	IP-10	CCR5	3627	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
15963988	0	IP-10	118,123	CXCL-10	124,131	IP-10	CXCL-10	3627	3627	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	TNF-alpha enhances phenotypic and functional maturation of human epidermal Langerhans cells and induces IL-12 p40 and IP-10 / CXCL-10 production .
12107104	0	IP-10	14,19	CXCL10	20,26	IP-10	CXCL10	3627	3627	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of IP-10 / CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10 / CXCL10 in the serum of patients with recent-onset Graves ' _ disease .
12107104	0	IP-10	14,19	CXCL10	86,92	IP-10	CXCL10	3627	3627	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of IP-10 / CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10 / CXCL10 in the serum of patients with recent-onset Graves ' _ disease .
16382019	0	IP-10	62,67	CXCL10	68,74	IP-10	CXCL10	245920(Tax:10116)	245920(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Compartment-specific expression and function of the chemokine IP-10 / CXCL10 in a model of renal_endothelial_microvascular_injury .
16825661	0	IP-10	8,13	CXCL10	14,20	IP-10	CXCL10	15945(Tax:10090)	15945(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of IP-10 / CXCL10 in the progression of pancreatitis-like_injury in mice after murine retroviral_infection .
21303517	0	IP-10	38,43	CXCL10	44,50	IP-10	CXCL10	3627	3627	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Dysregulated expression of MIG/CXCL9 , IP-10 / CXCL10 and CXCL16 and their receptors in systemic_sclerosis .
11029363	0	IP-10	15,20	CXCR3	79,84	IP-10	CXCR3	3627	2833	Gene	Gene	START_ENTITY|dep|cells cells|nummod|END_ENTITY	CXC chemokines IP-10 and mig expression and direct migration of pulmonary CD8 + / CXCR3 + T cells in the lungs of patients with HIV_infection_and_T-cell_alveolitis .
18811584	0	IP-10	118,123	CXCR3	137,142	IP-10	CXCR3	3627	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IP-10	118,123	IFN-beta	161,169	IP-10	IFN-beta	3627	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
17996064	0	IP-10	71,76	IFN-gamma-inducible_protein_10	39,69	IP-10	IFN-gamma-inducible protein 10	3627	3627	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The role of IFN-gamma in regulation of IFN-gamma-inducible_protein_10 -LRB- IP-10 -RRB- expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures .
12947309	0	IP-10	63,68	Interferon_regulatory_factor-1	0,30	IP-10	Interferon regulatory factor-1	15945(Tax:10090)	16362(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Interferon_regulatory_factor-1 down-regulates cytokine-induced IP-10 expression in pancreatic islets .
18811584	0	IP-10	118,123	MIP-1alpha	99,109	IP-10	MIP-1alpha	3627	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IP-10	118,123	PD1	144,147	IP-10	PD1	3627	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	IP-10	118,123	PDL2	149,153	IP-10	PDL2	3627	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
15194146	0	IP-10	38,43	TARC	70,74	IP-10	TARC	3627	6361	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants , TARC and MDC , are elevated in patients with systemic_sclerosis .
12668159	0	IP-10	0,5	leptin	41,47	IP-10	leptin	3627	3952	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	IP-10 , but not RANTES , is upregulated by leptin in monocytic cells .
14578618	0	IP10	32,36	CXCR3	0,5	IP10	CXCR3	3627	2833	Gene	Gene	interaction|compound|START_ENTITY chemokine|dobj|interaction chemokine|nsubj|END_ENTITY	CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary_artery_disease .
9541591	0	IP10	127,131	CXCR3	23,28	IP10	CXCR3	3627	2833	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig .
24378454	0	IP3R	81,85	Gp130	55,60	IP3R	Gp130	25262(Tax:10116)	25205(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Interleukin-6 prevents NMDA-induced neuronal_death via Gp130 signaling-dependent IP3R inhibition .
9566589	0	IP3R1	48,53	beta-actin	55,65	IP3R1	beta-actin	3708	728378	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Effects of ischemic tolerance on mRNA levels of IP3R1 , beta-actin , and neuron-specific enolase in hippocampal CA1 area of the gerbil brain .
26260683	0	IP3_receptor	86,98	Bcl-2	101,106	IP3 receptor	Bcl-2	3710	596	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP3_receptor / Bcl-2 complexes .
12491767	0	IP3_receptor	1,13	IP3_receptor	41,53	IP3 receptor	IP3 receptor	16438(Tax:10090)	16438(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	-LSB- IP3_receptor , a Ca2 + oscilator -- role of IP3_receptor in development and neural plasticity -RSB- .
12491767	0	IP3_receptor	41,53	IP3_receptor	1,13	IP3 receptor	IP3 receptor	16438(Tax:10090)	16438(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	-LSB- IP3_receptor , a Ca2 + oscilator -- role of IP3_receptor in development and neural plasticity -RSB- .
16527252	0	IP3_receptor	24,36	IRBIT	11,16	IP3 receptor	IRBIT	3710	10768	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of IRBIT to the IP3_receptor : determinants and functional effects .
16793548	0	IP3_receptor	17,29	IRBIT	0,5	IP3 receptor	IRBIT	3710	10768	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	IRBIT suppresses IP3_receptor activity by competing with IP3 for the common binding site on the IP3_receptor .
8313912	0	IP90	21,25	calnexin	11,19	IP90	calnexin	821	821	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for calnexin -LRB- IP90 -RRB- in the assembly of class II MHC molecules .
25085021	0	IPAF	45,49	IL-1b	24,29	IPAF	IL-1b	268973(Tax:10090)	16176(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY release|nmod|pathway release|compound|END_ENTITY	TLR4 activation induces IL-1b release via an IPAF dependent but caspase_1 / 11/8 independent pathway in the lung .
10545531	0	IPF-1	54,59	insulin_promoter_factor-1	27,52	IPF-1	insulin promoter factor-1	3651	3651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Defective mutations in the insulin_promoter_factor-1 -LRB- IPF-1 -RRB- gene in late-onset type_2_diabetes_mellitus .
8635654	0	IPF-1	93,98	insulin_promoter_factor_1	66,91	IPF-1	insulin promoter factor 1	3651	3651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation , characterization , and chromosomal mapping of the human insulin_promoter_factor_1 -LRB- IPF-1 -RRB- gene .
11270685	0	IPF1	56,60	MODY4	44,49	IPF1	MODY4	3651	3651	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Functional consequences of mutations in the MODY4 gene -LRB- IPF1 -RRB- and coexistence with MODY3 mutations .
17003361	0	IPF1	62,66	insulin_promoter_factor_1	35,60	IPF1	insulin promoter factor 1	3651	3651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of a proline insertion in the insulin_promoter_factor_1 -LRB- IPF1 -RRB- gene in African Americans with type 2 diabetes .
10601738	0	IPM_150	39,46	IMPG1	53,58	IPM 150	IMPG1	3617	3617	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Expression and characterization of the IPM_150 gene -LRB- IMPG1 -RRB- product , a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan .
19874272	0	IPP5	10,14	PP1	37,40	IPP5	PP1	151242	5464	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Effect of IPP5 , a novel inhibitor of PP1 , on apoptosis and the underlying mechanisms involved .
19635904	0	IPS-1	78,83	CD8_alpha	43,52	IPS-1	CD8 alpha	228607(Tax:10090)	12525(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Poly_I : C-induced activation of NK cells by CD8_alpha + dendritic cells via the IPS-1 and TRIF-dependent pathways .
19576240	0	IPS-1	16,21	IFNa1	44,49	IPS-1	IFNa1	57506	100137019(Tax:8030)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Atlantic_salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappaB and localizes to mitochondria .
20661427	0	IPS-1	82,87	MFN1	100,104	IPS-1	MFN1	57506	55669	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Virus-infection or 5 ` ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1 .
19576240	0	IPS-1	16,21	NF-kappaB	68,77	IPS-1	NF-kappaB	57506	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Atlantic_salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappaB and localizes to mitochondria .
25158146	0	IPS-1	116,121	Phosphatidylinositol-3-kinase	0,29	IPS-1	Phosphatidylinositol-3-kinase	57506	5293	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1 .
25950488	0	IPS-1	0,5	TRAIL	29,34	IPS-1	TRAIL	57506	8743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	IPS-1 differentially induces TRAIL , BCL2 , BIRC3 and PRKCE in type I interferons-dependent and - independent anticancer activity .
9368028	0	IPT1	110,114	YDR072c	116,123	IPT1	YDR072c	851644(Tax:4932)	851644(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Synthesis of mannose - -LRB- inositol-P -RRB- 2-ceramide , the major sphingolipid in Saccharomyces_cerevisiae , requires the IPT1 -LRB- YDR072c -RRB- gene .
17255093	0	IQ-domain_GTPase-activating_protein_1	0,37	beta-catenin	48,60	IQ-domain GTPase-activating protein 1	beta-catenin	8826	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IQ-domain_GTPase-activating_protein_1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous_polyposis_coli .
22483753	0	IQGAP1	0,6	Aurora-A	22,30	IQGAP1	Aurora-A	8826	6790	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	IQGAP1 interacts with Aurora-A and enhances its stability and its role in cancer .
23907317	0	IQGAP1	0,6	CA1	28,31	IQGAP1	CA1	29875(Tax:10090)	12346(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	IQGAP1 expression in spared CA1 neurons after an excitotoxic lesion in the mouse hippocampus .
19638411	0	IQGAP1	70,76	CLASP2	19,25	IQGAP1	CLASP2	8826	23122	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1 , EB1 and microtubules .
9368021	0	IQGAP1	49,55	Cdc42	70,75	IQGAP1	Cdc42	104968536	532712(Tax:9913)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Regulation of cross-linking of actin filament by IQGAP1 , a target for Cdc42 .
14970219	0	IQGAP1	0,6	ERK2	13,17	IQGAP1	ERK2	8826	5594	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	IQGAP1 binds ERK2 and modulates its activity .
24237756	0	IQGAP1	146,152	IQ_motif-containing_GTPase-activating_protein_1	97,144	IQGAP1	IQ motif-containing GTPase-activating protein 1	104968536	104968536	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A study based on records taken at time of hoof trimming reveals a strong association between the IQ_motif-containing_GTPase-activating_protein_1 -LRB- IQGAP1 -RRB- gene and sole hemorrhage in Holstein cattle .
24462863	0	IQGAP1	0,6	K-Ras	34,39	IQGAP1	K-Ras	8826	3845	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function .
21653857	0	IQGAP1	0,6	NR2A	17,21	IQGAP1	NR2A	29875(Tax:10090)	14811(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	IQGAP1 regulates NR2A signaling , spine density , and cognitive processes .
23788642	0	IQGAP1	39,45	Nrf2	55,59	IQGAP1	Nrf2	8826	4780	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase -LRB- ERK -RRB- kinase -LRB- MEK -RRB- - ERK pathway .
20875083	0	IQGAP1	65,71	RNase_L	15,22	IQGAP1	RNase L	8826	6041	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of RNase_L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line .
17517894	0	IQGAP1	0,6	Rap1	13,17	IQGAP1	Rap1	8826	5906	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	IQGAP1 binds Rap1 and modulates its activity .
26242911	0	IQGAP1	27,33	SKAP	87,91	IQGAP1	SKAP	8826	90417	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration .
22328503	0	IQGAP1	20,26	TOR	41,44	IQGAP1	TOR	8826	21977(Tax:10090)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	A conserved role of IQGAP1 in regulating TOR complex 1 .
24550401	0	IQGAP1	0,6	estrogen_receptor-a	16,35	IQGAP1	estrogen receptor-a	8826	2099	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	IQGAP1 binds to estrogen_receptor-a and modulates its function .
26398880	0	IQGAP1	61,67	miR-506	0,7	IQGAP1	miR-506	8826	574511	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-506 regulates breast_cancer cell metastasis by targeting IQGAP1 .
15217908	0	IQGAP1	0,6	vascular_endothelial_growth_factor	16,50	IQGAP1	vascular endothelial growth factor	361598(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	IQGAP1 , a novel vascular_endothelial_growth_factor receptor binding protein , is involved in reactive oxygen species -- dependent endothelial migration and proliferation .
27002143	0	IQ_Motif_and_SEC7_Domain-containing_Protein_3	0,45	gephyrin	70,78	IQ Motif and SEC7 Domain-containing Protein 3	gephyrin	440073	10243	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	IQ_Motif_and_SEC7_Domain-containing_Protein_3 -LRB- IQSEC3 -RRB- interacts with gephyrin to promote inhibitory synapse formation .
21885850	0	IQ_domain_GTPase-activating_protein_1	24,61	Angiopoietin-1	0,14	IQ domain GTPase-activating protein 1	Angiopoietin-1	8826	284	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	Angiopoietin-1 requires IQ_domain_GTPase-activating_protein_1 to activate Rac1 and promote endothelial barrier defense .
21885850	0	IQ_domain_GTPase-activating_protein_1	24,61	Rac1	74,78	IQ domain GTPase-activating protein 1	Rac1	8826	5879	Gene	Gene	START_ENTITY|xcomp|activate activate|dobj|END_ENTITY	Angiopoietin-1 requires IQ_domain_GTPase-activating_protein_1 to activate Rac1 and promote endothelial barrier defense .
24237756	0	IQ_motif-containing_GTPase-activating_protein_1	97,144	IQGAP1	146,152	IQ motif-containing GTPase-activating protein 1	IQGAP1	104968536	104968536	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A study based on records taken at time of hoof trimming reveals a strong association between the IQ_motif-containing_GTPase-activating_protein_1 -LRB- IQGAP1 -RRB- gene and sole hemorrhage in Holstein cattle .
21259294	0	IR	134,136	IGF-1R	110,116	IR	IGF-1R	24954(Tax:10116)	25718(Tax:10116)	Gene	Gene	dominance|nmod|START_ENTITY dominance|nmod|END_ENTITY	Unique expression pattern of the three insulin_receptor family members in the rat mammary gland : dominance of IGF-1R and IRR over the IR , and cyclical IGF-1R expression .
19170714	0	IR	116,118	insulin_receptor	98,114	IR	insulin receptor	3643	3643	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulin_receptor -LRB- IR -RRB- gene .
16046709	0	IRAK	116,120	EL-4	139,143	IRAK	EL-4	16179(Tax:10090)	111979(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Curcumin blocks interleukin-1 -LRB- IL-1 -RRB- signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells .
12751790	0	IRAK	69,73	IL-1RI	43,49	IRAK	IL-1RI	3654	3554	Gene	Gene	receptor|dep|START_ENTITY receptor|appos|END_ENTITY	Recruitment of the interleukin-1 receptor -LRB- IL-1RI -RRB- - associated kinase IRAK to the IL-1RI is redox regulated .
11254583	0	IRAK	53,57	MyD88	45,50	IRAK	MyD88	3654	4615	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
11254583	0	IRAK	53,57	NF-kappaB	79,88	IRAK	NF-kappaB	3654	4790	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
11254583	0	IRAK	53,57	NIK	67,70	IRAK	NIK	3654	9020	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
10854325	0	IRAK	53,57	Tollip	0,6	IRAK	Tollip	3654	54472	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Tollip , a new component of the IL-1RI pathway , links IRAK to the IL-1 receptor .
9371760	0	IRAK	15,19	interleukin_1_receptor_accessory_protein	67,107	IRAK	interleukin 1 receptor accessory protein	3654	3556	Gene	Gene	Recruitment|nmod|START_ENTITY requires|nsubj|Recruitment requires|dobj|END_ENTITY	Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin_1_receptor_accessory_protein .
19380824	0	IRAK-1	79,85	CD4	57,60	IRAK-1	CD4	16179(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|cells cells|compound|END_ENTITY	Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1 .
19380824	0	IRAK-1	79,85	Foxp3	27,32	IRAK-1	Foxp3	16179(Tax:10090)	20371(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1 .
18562480	0	IRAK-1	34,40	TNF_R1	82,88	IRAK-1	TNF R1	3654	7132	Gene	Gene	recruitment|nmod|START_ENTITY requires|nsubj|recruitment requires|dobj|END_ENTITY	Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF_R1 .
20937840	0	IRAK-1	71,77	microRNA-146a	93,106	IRAK-1	microRNA-146a	3654	406938	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of interleukin-1_receptor-associated_kinase-1 -LRB- IRAK-1 -RRB- and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer_disease .
15905496	0	IRAK-4	63,69	IL-1	28,32	IRAK-4	IL-1	51135	3552	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Cutting edge : expression of IL-1 receptor-associated kinase-4 -LRB- IRAK-4 -RRB- proteins with mutations identified in a patient with recurrent bacterial_infections alters normal IRAK-4 interaction with components of the IL-1 receptor complex .
20429783	0	IRAK-4	105,111	interleukin-1_receptor_associated_kinase_4	61,103	IRAK-4	interleukin-1 receptor associated kinase 4	51135	51135	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Quantitative structure-activity relationship -LRB- QSAR -RRB- study of interleukin-1_receptor_associated_kinase_4 -LRB- IRAK-4 -RRB- inhibitor activity by the genetic algorithm and multiple linear regression -LRB- GA-MLR -RRB- method .
21690387	0	IRAK-M	43,49	IL-1_receptor-associated_kinase-M	8,41	IRAK-M	IL-1 receptor-associated kinase-M	73914(Tax:10090)	73914(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of IL-1_receptor-associated_kinase-M -LRB- IRAK-M -RRB- in priming of immune and inflammatory responses by nitrogen bisphosphonates .
26218271	0	IRAK-M	101,107	IL-7	125,129	IRAK-M	IL-7	73914(Tax:10090)	16196(Tax:10090)	Gene	Gene	Mediated|nmod|START_ENTITY Mediated|nmod|END_ENTITY	Tolerance and Cross-Tolerance following Toll-Like_Receptor _ -LRB- TLR -RRB- -4 _ and _ -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes .
15275867	0	IRAK-M	41,47	TNF-alpha	67,76	IRAK-M	TNF-alpha	11213	7124	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Nitric_oxide activates the expression of IRAK-M via the release of TNF-alpha in human monocytes .
15833358	0	IRAK-M	119,125	alpha-melanocyte-stimulating_hormone	34,70	IRAK-M	alpha-melanocyte-stimulating hormone	11213	5443	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	The immunomodulating neuropeptide alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- suppresses LPS-stimulated TLR4 with IRAK-M in macrophages .
25341731	0	IRAK1	44,49	Interleukin_1_receptor-associated_kinase_1	0,42	IRAK1	Interleukin 1 receptor-associated kinase 1	3654	3654	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Interleukin_1_receptor-associated_kinase_1 -LRB- IRAK1 -RRB- mutation is a common , essential driver for Kaposi_sarcoma herpesvirus_lymphoma .
14673102	0	IRAK1	77,82	NF-kappaB	59,68	IRAK1	NF-kappaB	3654	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 activation of NF-kappaB through IRAK1 and TRAF6 .
12860405	0	IRAK1	45,50	Pellino2	20,28	IRAK1	Pellino2	3654	57161	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Pellino2 , a substrate of IRAK1 and IRAK4 .
18391954	0	IRAK1	109,114	SHP-1	12,17	IRAK1	SHP-1	3654	8431	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	Phosphatase SHP-1 promotes TLR - and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1 .
14673102	0	IRAK1	77,82	latent_membrane_protein_1	19,44	IRAK1	latent membrane protein 1	3654	9260	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 activation of NF-kappaB through IRAK1 and TRAF6 .
24642374	0	IRAK4	104,109	MicroRNA-93	0,11	IRAK4	MicroRNA-93	266632(Tax:10090)	723968(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-93 inhibits inflammatory cytokine production in LPS-stimulated murine macrophages by targeting IRAK4 .
26552593	0	IRAK4	85,90	MicroRNA367	0,11	IRAK4	MicroRNA367	266632(Tax:10090)	723911(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral_hemorrhage .
23209321	0	IRAK4	23,28	TLR2	48,52	MyD88	TLR2	4615	24088(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Complete dependence on IRAK4 kinase activity in TLR2 , but not TLR4 , signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus_pneumoniae_infection in IRAK4 kinase-inactive mice .
25558444	0	IRAP	48,52	Insulin-Regulated_Aminopeptidase	14,46	IRAP	Insulin-Regulated Aminopeptidase	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Insulin-Regulated_Aminopeptidase -LRB- IRAP -RRB- by Arylsulfonamides .
21216232	0	IRAP	15,19	Vimentin	0,8	IRAP	Vimentin	4012	7431	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking .
15187412	0	IRAP	45,49	insulin	53,60	IRAP	insulin	4012	3630	Gene	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Role of the insulin-regulated_aminopeptidase IRAP in insulin action and diabetes .
19647771	0	IRAP	72,76	insulin-regulated_aminopeptidase	38,70	IRAP	insulin-regulated aminopeptidase	240028(Tax:10090)	240028(Tax:10090)	Gene	Gene	behavior|appos|START_ENTITY behavior|nmod|END_ENTITY	Reproduction and maternal behavior in insulin-regulated_aminopeptidase -LRB- IRAP -RRB- knockout mice .
21476495	0	IRAP	67,71	insulin-regulated_aminopeptidase	33,65	IRAP	insulin-regulated aminopeptidase	4012	4012	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|nmod|END_ENTITY	Potent macrocyclic inhibitors of insulin-regulated_aminopeptidase -LRB- IRAP -RRB- by olefin ring-closing metathesis .
21679152	0	IRAP	80,84	insulin-regulated_aminopeptidase	46,78	IRAP	insulin-regulated aminopeptidase	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Alpha-1-adrenergic receptor blockade modifies insulin-regulated_aminopeptidase -LRB- IRAP -RRB- activity in rat prostate and modulates oxytocin functions .
12868002	0	IRAS	0,4	Nischarin	29,38	IRAS	Nischarin	11188	11188	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	IRAS , the human homologue of Nischarin , prolongs survival of transfected PC12 cells .
16527252	0	IRBIT	11,16	IP3_receptor	24,36	IRBIT	IP3 receptor	10768	3710	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of IRBIT to the IP3_receptor : determinants and functional effects .
16793548	0	IRBIT	0,5	IP3_receptor	17,29	IRBIT	IP3 receptor	10768	3710	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|amod|END_ENTITY	IRBIT suppresses IP3_receptor activity by competing with IP3 for the common binding site on the IP3_receptor .
27062503	0	IRBIT	17,22	ITPR1	33,38	IRBIT	ITPR1	10768	3708	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Mutations in the IRBIT domain of ITPR1 are a frequent cause of autosomal dominant nonprogressive congenital_ataxia .
12069545	0	IRBP	100,104	cytochrome_b	141,153	IRBP	cytochrome b	5949	4519	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Phylogeny of the genus Apodemus with a special emphasis on the subgenus Sylvaemus using the nuclear IRBP gene and two mitochondrial markers : cytochrome_b and 12S rRNA .
8328337	0	IRBP	56,60	interphotoreceptor-retinoid-binding-protein	11,54	IRBP	interphotoreceptor-retinoid-binding-protein	100723349	100723349	Gene	Gene	Change|appos|START_ENTITY Change|nmod|END_ENTITY	-LSB- Change in interphotoreceptor-retinoid-binding-protein -LRB- IRBP -RRB- after retinal_photocoagulation and cryopexy -RSB- .
11134581	0	IRBP	59,63	interphotoreceptor_retinoid-binding_protein	14,57	IRBP	interphotoreceptor retinoid-binding protein	5949	5949	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- gene expression by cAMP in differentiated retinoblastoma cells .
11278819	0	IRBP	133,137	interphotoreceptor_retinoid-binding_protein	83,126	IRBP	interphotoreceptor retinoid-binding protein	5949	5949	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The zinc finger transcription factor , MOK2 , negatively modulates expression of the interphotoreceptor_retinoid-binding_protein gene , IRBP .
11821982	0	IRBP	129,133	interphotoreceptor_retinoid-binding_protein	84,127	IRBP	interphotoreceptor retinoid-binding protein	281443(Tax:9913)	281443(Tax:9913)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Structural characterization and comparison of promoter activity of mouse and bovine interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- gene 5 ' flanking regions in WERI , Y79 , chick retina cells , and transgenic_mice .
1426058	0	IRBP	90,94	interphotoreceptor_retinoid-binding_protein	45,88	IRBP	interphotoreceptor retinoid-binding protein	5949	5949	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Photoreceptor-specific activity of the human interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- promoter in transgenic_mice .
2592435	0	IRBP	72,76	interphotoreceptor_retinoid-binding_protein	27,70	IRBP	interphotoreceptor retinoid-binding protein	19661(Tax:10090)	19661(Tax:10090)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and secretion of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- by isolated normal and rd mouse retinal photoreceptor neurons in culture .
2697513	0	IRBP	74,78	interphotoreceptor_retinoid-binding_protein	29,72	IRBP	interphotoreceptor retinoid-binding protein	5949	5949	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Differential distribution of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- around retinal rod and cone photoreceptors .
9841935	0	IRBP	73,77	interphotoreceptor_retinoid-binding_protein	28,71	IRBP	interphotoreceptor retinoid-binding protein	30735(Tax:7955)	30735(Tax:7955)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Novel expression pattern of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- in the adult and developing zebrafish retina and RPE .
1987260	0	IRBP	58,62	interphotoreceptor_retinoid_binding_protein	13,56	IRBP	interphotoreceptor retinoid binding protein	5949	5949	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Detection of interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- mRNA in human and cone-dominant squirrel retinas by in situ hybridization .
8660440	0	IRBP	73,77	interphotoreceptor_retinoid_binding_protein	28,71	IRBP	interphotoreceptor retinoid binding protein	5949	5949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mammalian evolution and the interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- gene : convincing evidence for several superordinal clades .
6686234	0	IRBP	70,74	interphotoreceptor_retinol-binding_protein	26,68	IRBP	interphotoreceptor retinol-binding protein	5949	5949	Gene	Gene	presence|appos|START_ENTITY presence|nmod|END_ENTITY	The presence of a soluble interphotoreceptor_retinol-binding_protein -LRB- IRBP -RRB- in the retinal interphotoreceptor_space .
10372988	0	IRBP	86,90	interstitial_retinoid-binding_protein	47,84	IRBP	interstitial retinoid-binding protein	5949	5949	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Elements regulating the transcription of human interstitial_retinoid-binding_protein -LRB- IRBP -RRB- gene in cultured retinoblastoma cells .
10750831	0	IRBP	36,40	rhodopsin	4,13	IRBP	rhodopsin	19661(Tax:10090)	212541(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY preserved|nmod|mice preserved|nsubjpass|cycle cycle|compound|END_ENTITY	The rhodopsin cycle is preserved in IRBP `` knockout '' mice despite abnormalities in retinal structure and function .
1623951	0	IRBP	96,100	rhodopsin	37,46	IRBP	rhodopsin	281443(Tax:9913)	509933(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Early expression and localization of rhodopsin and interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- in the developing fetal bovine retina .
8150029	0	IRBP	45,49	rhodopsin	60,69	IRBP	rhodopsin	5949	6010	Gene	Gene	Interphotoreceptor_retinoid_binding_protein|appos|START_ENTITY enhances|nsubj|Interphotoreceptor_retinoid_binding_protein enhances|dobj|regeneration regeneration|compound|END_ENTITY	Interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- enhances rhodopsin regeneration in the experimentally detached retina .
9352446	0	IRBP	104,108	rhodopsin	8,17	IRBP	rhodopsin	19661(Tax:10090)	212541(Tax:10090)	Gene	Gene	interphotoreceptor_retinoid_binding_protein|appos|START_ENTITY regeneration|nmod|interphotoreceptor_retinoid_binding_protein regeneration|compound|END_ENTITY	Delayed rhodopsin regeneration and altered distribution of interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- in the mi -LRB- vit -RRB- / mi -LRB- vit -RRB- -LRB- vitiligo -RRB- mouse .
24812669	0	IRE-1	35,40	XBP-1	41,46	IRE-1	XBP-1	26918(Tax:10090)	22433(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|reduces reduces|nsubj|END_ENTITY	Inhibition of ER stress-associated IRE-1 / XBP-1 pathway reduces leukemic cell survival .
25469499	0	IRE-1	0,5	XBP-1	6,11	IRE-1	XBP-1	174305(Tax:6239)	175541(Tax:6239)	Gene	Gene	START_ENTITY|appos|required required|nsubjpass|pathway pathway|compound|END_ENTITY	IRE-1 / XBP-1 pathway of the unfolded protein response is required for properly localizing neuronal UNC-6 / Netrin for axon guidance in C. __ elegans .
27055592	0	IRE-1	59,64	XBP-1	65,70	IRE-1	XBP-1	174305(Tax:6239)	175541(Tax:6239)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	PEK-1 is crucial for hormesis induced by inhibition of the IRE-1 / XBP-1 pathway in the Caenorhabditis_elegans mev-1 mutant .
25870107	0	IRE1	28,32	BLOC1S1	12,19	IRE1	BLOC1S1	2081	2647	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Cleavage of BLOC1S1 mRNA by IRE1 is sequence-specific , temporally separate from XBP1 splicing , and dispensable for cell viability under acute ER-stress .
22446326	0	IRE1	50,54	BiP	17,20	IRE1	BiP	2081	2662	Gene	Gene	requires|nsubj|START_ENTITY transducers|ccomp|requires transducers|nsubj|Binding Binding|nmod|END_ENTITY	Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP .
15465829	0	IRE1	44,48	Protein-tyrosine_phosphatase_1B	0,31	IRE1	Protein-tyrosine phosphatase 1B	26918(Tax:10090)	19246(Tax:10090)	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	Protein-tyrosine_phosphatase_1B potentiates IRE1 signaling during endoplasmic reticulum stress .
23473031	0	IRE1a	78,83	netrin-1	99,107	IRE1a	netrin-1	2081	9423	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1a degradation of netrin-1 .
22883233	0	IRE1a	0,5	thioredoxin-interacting_protein	14,45	IRE1a	thioredoxin-interacting protein	78943(Tax:10090)	56338(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	IRE1a induces thioredoxin-interacting_protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress .
19328063	0	IRE1alpha	64,73	BAX_inhibitor-1	0,15	IRE1alpha	BAX inhibitor-1	78943(Tax:10090)	110213(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	BAX_inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha .
19996103	0	IRE1alpha	33,42	Bax_inhibitor-1	8,23	IRE1alpha	Bax inhibitor-1	78943(Tax:10090)	110213(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Hepatic Bax_inhibitor-1 inhibits IRE1alpha and protects from obesity-associated insulin resistance and glucose_intolerance .
20103773	0	IRE1alpha	65,74	RACK1	19,24	IRE1alpha	RACK1	78943(Tax:10090)	14694(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells .
19135427	0	IRE1alpha	62,71	USP14	0,5	IRE1alpha	USP14	2081	9097	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	USP14 inhibits ER-associated degradation via interaction with IRE1alpha .
23168839	0	IRE1b	25,30	mucin	65,70	IRE1b	mucin	10595	100508689	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|production production|compound|END_ENTITY	The ER stress transducer IRE1b is required for airway epithelial mucin production .
15897636	0	IREG1	52,57	ferroportin_1	37,50	IREG1	ferroportin 1	30061	30061	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hemochromatosis with mutation of the ferroportin_1 -LRB- IREG1 -RRB- gene .
17918184	0	IRF-1	27,32	EGFR	0,4	IRF-1	EGFR	3659	1956	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells .
1886766	0	IRF-1	34,39	IFN-beta	14,22	IRF-1	IFN-beta	3659	3456	Gene	Gene	element|nmod|START_ENTITY element|amod|END_ENTITY	Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis .
10376977	0	IRF-1	103,108	IFN-gamma	51,60	IRF-1	IFN-gamma	3659	3458	Gene	Gene	mRNA|compound|START_ENTITY induction|nmod|mRNA associated|nmod|induction associated|nsubjpass|response response|nmod|lines lines|nmod|END_ENTITY	Cytotoxic response of ovarian_cancer cell lines to IFN-gamma is associated with sustained induction of IRF-1 and p21 mRNA .
10882409	0	IRF-1	86,91	IFN-gamma	0,9	IRF-1	IFN-gamma	16362(Tax:10090)	15978(Tax:10090)	Gene	Gene	modulation|compound|START_ENTITY regulate|nmod|modulation regulate|nsubj|END_ENTITY	IFN-gamma and IL-4 differently regulate inducible_NO_synthase gene expression through IRF-1 modulation .
12479817	0	IRF-1	40,45	IFN-gamma	0,9	IRF-1	IFN-gamma	3659	3458	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 .
12584735	0	IRF-1	8,13	IFN-gamma	31,40	IRF-1	IFN-gamma	3659	3458	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|enhancement enhancement|amod|END_ENTITY	Role of IRF-1 and caspase-7 in IFN-gamma enhancement of Fas-mediated apoptosis in ACHN_renal_cell_carcinoma cells .
15511228	0	IRF-1	51,56	IFN-gamma	0,9	IRF-1	IFN-gamma	3659	3458	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	IFN-gamma enhances TRAIL-induced apoptosis through IRF-1 .
15871905	0	IRF-1	0,5	IFN-gamma	122,131	IRF-1	IFN-gamma	16362(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|dep|bind bind|nmod|END_ENTITY	IRF-1 and NF-kappaB_p50 / cRel bind to distinct regions of the proximal murine IL-12_p35 promoter during costimulation with IFN-gamma and LPS .
15907481	0	IRF-1	0,5	IFN-gamma	39,48	IRF-1	IFN-gamma	16362(Tax:10090)	15978(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|expression expression|amod|END_ENTITY	IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome .
23807161	0	IRF-1	0,5	IFN-y	24,29	IRF-1	IFN-y	3659	3458	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	IRF-1 responsiveness to IFN-y predicts different cancer immune phenotypes .
12479817	0	IRF-1	40,45	IL-4	20,24	IRF-1	IL-4	3659	3565	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	IFN-gamma represses IL-4 expression via IRF-1 and IRF-2 .
10566682	0	IRF-1	103,108	IRF-1	48,53	IRF-1	IRF-1	3659	3659	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Localization of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in nonpregnant human endometrium : expression of IRF-1 is up-regulated by prolactin during the secretory phase of the menstrual cycle .
10566682	0	IRF-1	48,53	IRF-1	103,108	IRF-1	IRF-1	3659	3659	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Localization of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in nonpregnant human endometrium : expression of IRF-1 is up-regulated by prolactin during the secretory phase of the menstrual cycle .
18291530	0	IRF-1	80,85	IRF-2	88,93	IRF-1	IRF-2	3659	3660	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Gene structures and promoter characteristics of interferon regulatory factor 1 -LRB- IRF-1 -RRB- , IRF-2 and IRF-7 from snakehead Channa_argus .
22182512	0	IRF-1	72,77	MKP-7	0,5	IRF-1	MKP-7	3659	80824	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
25880742	0	IRF-1	48,53	PGC-1a	0,6	IRF-1	PGC-1a	16362(Tax:10090)	19017(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PGC-1a regulates the expression and activity of IRF-1 .
25880742	0	IRF-1	48,53	PGC-1a	0,6	IRF-1	PGC-1a	16362(Tax:10090)	19017(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PGC-1a regulates the expression and activity of IRF-1 .
16555329	0	IRF-1	115,120	STAT-1	108,114	IRF-1	STAT-1	24508(Tax:10116)	25124(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1 / IRF-1 pathway during tolerance induction .
17918184	0	IRF-1	27,32	STAT1	37,42	IRF-1	STAT1	3659	6772	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells .
10918594	0	IRF-1	115,120	Stat-1	43,49	IRF-1	Stat-1	3659	6772	Gene	Gene	induction|nmod|START_ENTITY apoptosis|nmod|induction apoptosis|amod|END_ENTITY	IFN-beta induces serine phosphorylation of Stat-1 in Ewing 's _ sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7 .
11804954	0	IRF-1	98,103	Stat1	9,14	IRF-1	Stat1	3659	6772	Gene	Gene	regulation|nmod|START_ENTITY Roles|nmod|regulation Roles|nmod|END_ENTITY	Roles of Stat1 , Stat2 , and interferon_regulatory_factor-9 -LRB- IRF-9 -RRB- in interferon tau regulation of IRF-1 .
14668793	0	IRF-1	98,103	Stat1	35,40	IRF-1	Stat1	3659	6772	Gene	Gene	expression|nmod|START_ENTITY leading|nmod|expression interferon_gamma|acl|leading enhances|nmod|interferon_gamma enhances|dobj|activation activation|nmod|END_ENTITY	Arsenic enhances the activation of Stat1 by interferon_gamma leading to synergistic expression of IRF-1 .
12537697	0	IRF-1	47,52	cyclooxygenase-2	79,95	IRF-1	cyclooxygenase-2	16362(Tax:10090)	19225(Tax:10090)	Gene	Gene	role|amod|START_ENTITY role|nmod|END_ENTITY	The role of the interferon regulatory factors , IRF-1 and IRF-2 , in LPS-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vivo and in vitro .
1614874	0	IRF-1	66,71	interferon-alpha	30,46	IRF-1	interferon-alpha	16362(Tax:10090)	111654(Tax:10090)	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Distinct activation of murine interferon-alpha promoter region by IRF-1 / ISFG-2 and virus_infection .
17516545	0	IRF-1	48,53	interferon_regulatory_factor-1	16,46	IRF-1	interferon regulatory factor-1	3659	3659	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Central role of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in controlling retinoic_acid_inducible_gene-I -LRB- RIG-I -RRB- expression .
8034037	0	IRF-1	74,79	interferon_regulatory_factor_1	42,72	IRF-1	interferon regulatory factor 1	3659	3659	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Possible role of the transcription factor interferon_regulatory_factor_1 -LRB- IRF-1 -RRB- in the regulation of ornithine_decarboxylase -LRB- ODC -RRB- gene expression during IFN_gamma macrophage activation .
23670564	0	IRF-1	38,43	p300	0,4	IRF-1	p300	3659	2033	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	p300 , but not PCAF , collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity .
17516545	0	IRF-1	48,53	retinoic_acid_inducible_gene-I	70,100	IRF-1	retinoic acid inducible gene-I	3659	23586	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Central role of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in controlling retinoic_acid_inducible_gene-I -LRB- RIG-I -RRB- expression .
10674401	0	IRF-1	186,191	stat1	110,115	IRF-1	stat1	3659	6772	Gene	Gene	promoter|compound|START_ENTITY signaling|nmod|promoter END_ENTITY|acl|signaling	Association of 2 ' ,5 ' - oligoadenylate_synthetase with the prolactin _ -LRB- PRL -RRB- _ receptor : alteration in PRL-inducible stat1 -LRB- signal_transducer_and_activator_of_transcription_1 -RRB- signaling to the IRF-1 -LRB- interferon-regulatory_factor_1 -RRB- promoter .
9679752	0	IRF-1	65,70	tumor-suppressor	48,64	IRF-1	tumor-suppressor	3659	7248	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric_cancer .
18291530	0	IRF-2	88,93	IRF-1	80,85	IRF-2	IRF-1	3660	3659	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Gene structures and promoter characteristics of interferon regulatory factor 1 -LRB- IRF-1 -RRB- , IRF-2 and IRF-7 from snakehead Channa_argus .
18395009	0	IRF-2	0,5	NF-kappaB	16,25	IRF-2	NF-kappaB	3660	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB .
16154084	0	IRF-3	21,26	CBP	43,46	IRF-3	CBP	3661	1387	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of IRF-3 in complex with CBP .
23027953	0	IRF-3	27,32	IFI16	8,13	IRF-3	IFI16	3661	3428	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein .
23027953	0	IRF-3	27,32	IFI16	91,96	IRF-3	IFI16	3661	3428	Gene	Gene	induction|nmod|START_ENTITY induction|acl|signaling signaling|nmod|infection infection|nmod|END_ENTITY	Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein .
24335302	0	IRF-3	7,12	IRF-7	20,25	IRF-3	IRF-7	54131(Tax:10090)	54123(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis : lessons from a murine retrovirus-induced AIDS model .
14668346	0	IRF-3	107,112	vIRF-3	48,54	IRF-3	vIRF-3	3661	4961493(Tax:37296)	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus-encoded vIRF-3 stimulates the transcriptional activity of cellular IRF-3 and IRF-7 .
10714679	0	IRF-4	32,37	FKBP52	67,73	IRF-4	FKBP52	3662	2288	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity regulation|nmod|END_ENTITY	Posttranslational regulation of IRF-4 activity by the immunophilin FKBP52 .
21728176	0	IRF-4	15,20	SWAP-70	35,42	IRF-4	SWAP-70	16364(Tax:10090)	20947(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Fine tuning of IRF-4 expression by SWAP-70 controls the initiation of plasma cell development .
10770796	0	IRF-4	44,49	interferon_regulatory_factor_4	12,42	IRF-4	interferon regulatory factor 4	3662	3662	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Rel induces interferon_regulatory_factor_4 -LRB- IRF-4 -RRB- expression in lymphocytes : modulation of interferon-regulated gene expression by rel/nuclear factor kappaB .
19062315	0	IRF-4-binding_protein	0,21	interleukin-17	31,45	IRF-4-binding protein	interleukin-17	23853(Tax:10090)	16171(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	IRF-4-binding_protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor .
24335302	0	IRF-7	20,25	IRF-3	7,12	IRF-7	IRF-3	54123(Tax:10090)	54131(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis : lessons from a murine retrovirus-induced AIDS model .
20980251	0	IRF-7	79,84	ORF45	136,141	IRF-7	ORF45	3665	4961474(Tax:37296)	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|nmod|END_ENTITY	Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi 's _ sarcoma-associated_herpesvirus protein ORF45 .
11877397	0	IRF-7	15,20	tumor_necrosis_factor_alpha	40,67	IRF-7	tumor necrosis factor alpha	3665	7124	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Stimulation of IRF-7 gene expression by tumor_necrosis_factor_alpha : requirement for NFkappa_B transcription factor and gene accessibility .
15688197	0	IRF-8	24,29	ICSBP	17,22	IRF-8	ICSBP	292060(Tax:10116)	292060(Tax:10116)	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Analysis of PU .1 / ICSBP -LRB- IRF-8 -RRB- complex formation with various PU .1 mutants : molecular cloning of rat Icsbp -LRB- Irf-8 -RRB- cDNA .
22295238	0	IRF1	44,48	Interferon_Regulatory_Factor-1	12,42	IRF1	Interferon Regulatory Factor-1	3659	3659	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Interferon_Regulatory_Factor-1 -LRB- IRF1 -RRB- in Overcoming Antiestrogen Resistance in the Treatment of Breast_Cancer .
22240255	0	IRF1	103,107	interferon-gamma	76,92	IRF1	interferon-gamma	3659	3458	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene .
17475929	0	IRF1	65,69	interferon-regulatory_factor_1	33,63	IRF1	interferon-regulatory factor 1	396611(Tax:9823)	396611(Tax:9823)	Gene	Gene	increase|appos|START_ENTITY increase|amod|END_ENTITY	Pig conceptuses increase uterine interferon-regulatory_factor_1 -LRB- IRF1 -RRB- , but restrict expression to stroma through estrogen-induced IRF2 in luminal epithelium .
1680796	0	IRF1	56,60	interferon_regulatory_factor-1	24,54	IRF1	interferon regulatory factor-1	3659	3659	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human interferon_regulatory_factor-1 -LRB- IRF1 -RRB- gene to chromosome 5q23-q31 .
20825659	0	IRF1	218,222	interferon_regulatory_factor_1	181,211	IRF1	interferon regulatory factor 1	3659	3659	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal_transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- - activated transcription of the interferon_regulatory_factor_1 gene -LRB- IRF1 -RRB- .
24954358	0	IRF1	49,53	interferon_regulatory_factor_1	17,47	IRF1	interferon regulatory factor 1	16362(Tax:10090)	16362(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for interferon_regulatory_factor_1 -LRB- IRF1 -RRB- in regulation of bone metabolism .
9213219	0	IRF2	86,90	interferon_regulatory_factor_2	54,84	IRF2	interferon regulatory factor 2	3660	3660	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of the oncogenic transcription factor interferon_regulatory_factor_2 -LRB- IRF2 -RRB- in vitro and in vivo .
25506707	0	IRF3	21,25	HSPD1	0,5	IRF3	HSPD1	3661	3329	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	HSPD1 Interacts with IRF3 to Facilitate Interferon-Beta Induction .
16199137	0	IRF3	22,26	IKK-i	0,5	IRF3	IKK-i	3661	9641	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines .
25636800	0	IRF3	80,84	TRIF	67,71	IRF3	TRIF	3661	148022	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Phosphorylation of innate immune adaptor proteins MAVS , STING , and TRIF induces IRF3 activation .
22479513	0	IRF3	97,101	TRIM21	52,58	IRF3	TRIM21	3661	6737	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity .
25763818	0	IRF3	129,133	TRIM26	0,6	IRF3	TRIM26	54131(Tax:10090)	22670(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	TRIM26 Negatively Regulates Interferon-b Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3 .
20631144	0	IRF3	89,93	interferon_regulatory_factor_3	57,87	IRF3	interferon regulatory factor 3	3661	3661	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Varicella-zoster_virus immediate-early protein 62 blocks interferon_regulatory_factor_3 -LRB- IRF3 -RRB- phosphorylation at key serine residues : a novel mechanism of IRF3 inhibition among herpesviruses .
22158869	0	IRF3	165,169	interferon_regulatory_factor_3	133,163	IRF3	interferon regulatory factor 3	54131(Tax:10090)	54131(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Phospholipase Cy-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like_receptor_4 -LRB- TLR4 -RRB- endocytosis and interferon_regulatory_factor_3 -LRB- IRF3 -RRB- activation .
21919915	0	IRF4	24,28	CD4	41,44	IRF4	CD4	3662	920	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of IRF4 and ETS1 in CD4 + cells from patients with intermittent_allergic_rhinitis .
19821826	0	IRF4	0,4	CD40L	21,26	IRF4	CD40L	3662	959	Gene	Gene	modulated|nsubjpass|START_ENTITY modulated|nmod|END_ENTITY	IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin_lymphoma .
19843941	0	IRF4	77,81	Fas_apoptosis_inhibitory_molecule	0,33	IRF4	Fas apoptosis inhibitory molecule	3662	55179	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Fas_apoptosis_inhibitory_molecule expression in B cells is regulated through IRF4 in a feed-forward mechanism .
21305677	0	IRF4	0,4	IL-17A	15,21	IRF4	IL-17A	3662	3605	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	IRF4 regulates IL-17A promoter activity and controls RORyt-dependent Th17 colitis in vivo .
22961652	0	IRF4	71,75	IL-17A	98,104	IRF4	IL-17A	16364(Tax:10090)	16171(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Unlike ab T cells , y T cells , LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22 .
23666852	0	IRF4	0,4	JNK	36,39	IRF4	JNK	3662	5599	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	IRF4 promotes cell proliferation by JNK pathway in multiple myeloma .
11749693	0	IRF4	56,60	interferon_regulatory_factor_4	24,54	IRF4	interferon regulatory factor 4	3662	3662	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of interferon_regulatory_factor_4 -LRB- IRF4 -RRB- in a clinical subtype of adult_T-cell_leukemia .
25337792	0	IRF5	45,49	IFIH1	38,43	IRF5	IFIH1	3663	64135	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|appos|END_ENTITY	Genetic Association Study of TNFAIP3 , IFIH1 , IRF5 Polymorphisms with Polymyositis/Dermatomyositis in Chinese Han Population .
26519527	0	IRF5	57,61	IFN-a	75,80	IRF5	IFN-a	3663	3438	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-a Production in Women .
18268344	0	IRF5	62,66	IFN_regulatory_factor_5	37,60	IRF5	IFN regulatory factor 5	27056(Tax:10090)	27056(Tax:10090)	Gene	Gene	requirement|appos|START_ENTITY requirement|nmod|END_ENTITY	A cell-type-specific requirement for IFN_regulatory_factor_5 -LRB- IRF5 -RRB- in Fas-induced apoptosis .
17881657	0	IRF5	74,78	interferon_regulatory_Factor_5	42,72	IRF5	interferon regulatory Factor 5	3663	3663	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An insertion-deletion polymorphism in the interferon_regulatory_Factor_5 -LRB- IRF5 -RRB- gene confers risk of inflammatory_bowel_diseases .
20127100	0	IRF5	69,73	interferon_regulatory_factor_5	37,67	IRF5	interferon regulatory factor 5	3663	3663	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Assessment of DNA methylation at the interferon_regulatory_factor_5 -LRB- IRF5 -RRB- promoter region in inflammatory_bowel_diseases .
22053985	0	IRF5	40,44	interferon_regulatory_factor_5	8,38	IRF5	interferon regulatory factor 5	3663	3663	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Loss of interferon_regulatory_factor_5 -LRB- IRF5 -RRB- expression in human ductal_carcinoma correlates with disease stage and contributes to metastasis .
25564941	0	IRF5	77,81	interferon_regulatory_factor_5	45,75	IRF5	interferon regulatory factor 5	3663	3663	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between genetic polymorphisms in interferon_regulatory_factor_5 -LRB- IRF5 -RRB- gene and Malaysian patients with Crohn 's _ disease .
25896037	0	IRF6	0,4	AP-2a	5,10	IRF6	AP-2a	3664	7020	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	IRF6 AP-2a binding site promoter polymorphism is associated with oral clefts in Latvia .
22815909	0	IRF7	0,4	CD11c	51,56	IRF7	CD11c	54123(Tax:10090)	16411(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	IRF7 regulates TLR2-mediated activation of splenic CD11c -LRB- hi -RRB- dendritic cells .
20392859	0	IRF7	72,76	LMP1	53,57	IRF7	LMP1	3665	9260	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7 .
25907537	0	IRF7	94,98	TRIM35	0,6	IRF7	TRIM35	3665	23087	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	TRIM35 negatively regulates TLR7 - and TLR9-mediated type I interferon production by targeting IRF7 .
21148039	0	IRF7	23,27	activating_transcription_factor_4	42,75	IRF7	activating transcription factor 4	3665	468	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Negative regulation of IRF7 activation by activating_transcription_factor_4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses .
21949018	0	IRF8	14,18	Bax	29,32	IRF8	Bax	15900(Tax:10090)	12028(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Cutting edge : IRF8 regulates Bax transcription in vivo in primary myeloid cells .
25236377	0	IRF8	0,4	C/EBPa	14,20	IRF8	C/EBPa	3394	1050	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	IRF8 inhibits C/EBPa activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils .
24485804	0	IRF8	25,29	TGF-b	58,63	IRF8	TGF-b	15900(Tax:10090)	21803(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The transcription factor IRF8 activates integrin-mediated TGF-b signaling and promotes neuroinflammation .
21487040	0	IRF8	0,4	acid_ceramidase	15,30	IRF8	acid ceramidase	3394	427	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	IRF8 regulates acid_ceramidase expression to mediate apoptosis and suppresses myelogeneous_leukemia .
21757726	0	IRGM	27,31	Immunity-related_GTPase_M	0,25	IRGM	Immunity-related GTPase M	345611	345611	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Immunity-related_GTPase_M -LRB- IRGM -RRB- proteins influence the localization of guanylate-binding_protein_2 -LRB- GBP2 -RRB- by modulating macroautophagy .
15970401	0	IRP1	10,14	Friedreich_ataxia	27,44	IRP1	Friedreich ataxia	48	2395	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Increased IRP1 activity in Friedreich_ataxia .
10535406	0	IRR	107,110	insulin_receptor-related_receptor	72,105	IRR	insulin receptor-related receptor	3645	3645	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Correlation of type_I_insulin-like_growth factor receptor -LRB- IGF-I-R -RRB- and insulin_receptor-related_receptor -LRB- IRR -RRB- messenger RNA levels in tumor cell lines from pediatric_tumors of neuronal origin .
20018868	0	IRS-1	44,49	AKT	51,54	IRS-1	AKT	3667	207	Gene	Gene	insulin_receptor_substrate_1|appos|START_ENTITY Regulation|nmod|insulin_receptor_substrate_1 Regulation|parataxis|signaling signaling|nsubj|insulin insulin|compound|END_ENTITY	Regulation of insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- / AKT kinase-mediated insulin signaling by O-Linked_beta-N-acetylglucosamine in 3T3-L1 adipocytes .
22820890	0	IRS-1	104,109	Akt	110,113	IRS-1	Akt	3667	207	Gene	Gene	overexpressing|nmod|START_ENTITY impaired|xcomp|overexpressing ameliorates|acl|impaired ameliorates|parataxis|signaling signaling|nsubj|END_ENTITY	a-Lipoic_acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1 / Akt signaling pathway .
23639858	0	IRS-1	131,136	Akt	137,140	IRS-1	Akt	16367(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Paraoxonase1 -LRB- PON1 -RRB- reduces insulin resistance in mice fed a high-fat diet , and promotes GLUT4 overexpression in myocytes , via the IRS-1 / Akt pathway .
10080958	0	IRS-1	14,19	GLUT4	59,64	IRS-1	GLUT4	25467(Tax:10116)	25139(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY Inhibition|nmod|phosphorylation Inhibition|nmod|END_ENTITY	Inhibition of IRS-1 phosphorylation and the alterations of GLUT4 in isolated adipocytes from cachectic tumor-bearing rats .
11230180	0	IRS-1	81,86	Grb-2	113,118	IRS-1	Grb-2	3667	2885	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|dep|END_ENTITY	PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1 / Grb-2 / Sos complex formation in a breast_cancer model .
12493740	0	IRS-1	152,157	Grb10	0,5	IRS-1	Grb10	3667	2887	Gene	Gene	IRS-2|compound|START_ENTITY association|nmod|IRS-2 disrupting|dobj|association signaling|advcl|disrupting 3-kinase/Akt|acl|signaling substrate|dep|3-kinase/Akt substrate|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
10049759	0	IRS-1	16,21	IGF-I	0,5	IRS-1	IGF-I	3667	3479	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IGF-I regulates IRS-1 expression in 3T3-L1 adipocytes .
12101028	0	IRS-1	54,59	IGF-I	106,111	IRS-1	IGF-I	16367(Tax:10090)	16000(Tax:10090)	Gene	Gene	insulin_receptor_substrate-1|appos|START_ENTITY expression|nmod|insulin_receptor_substrate-1 fails|nsubj|expression fails|xcomp|block block|dobj|stimulation stimulation|appos|END_ENTITY	Deficient expression of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- fails to block insulin-like_growth_factor-I -LRB- IGF-I -RRB- stimulation of brain growth and myelination .
11522686	0	IRS-1	38,43	IRS-2	62,67	IRS-1	IRS-2	3667	8660	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic_ovary_syndrome .
11788357	0	IRS-1	60,65	IRS-2	68,73	IRS-1	IRS-2	25467(Tax:10116)	29376(Tax:10116)	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Calorie restriction increases muscle insulin action but not IRS-1 - , IRS-2 - , or phosphotyrosine-PI 3-kinase .
16921752	0	IRS-1	65,70	IRS-2	72,77	IRS-1	IRS-2	25467(Tax:10116)	29376(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	-LSB- Influence of chronic ethanol intake insulin sensitivity and IR , IRS-1 , IRS-2 mRNA expression of liver in male rats -RSB- .
8902843	0	IRS-1	85,90	Insulin_receptor	0,16	IRS-1	Insulin receptor	3667	3643	Gene	Gene	complex|nmod|START_ENTITY formation|nmod|complex END_ENTITY|nmod|formation	Insulin_receptor structural requirements for the formation of a ternary complex with IRS-1 and PI 3-kinase .
19996384	0	IRS-1	130,135	c-Jun_NH2-terminal_kinase	74,99	IRS-1	c-Jun NH2-terminal kinase	25467(Tax:10116)	116554(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Exercise maintains euglycemia in association with decreased activation of c-Jun_NH2-terminal_kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats .
11484076	0	IRS-1	194,199	insulin_receptor	164,180	IRS-1	insulin receptor	25467(Tax:10116)	24954(Tax:10116)	Gene	Gene	that|nmod|START_ENTITY END_ENTITY|nmod|that	Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin_receptor from that of IRS-1 .
12493740	0	IRS-1	152,157	insulin_receptor	173,189	IRS-1	insulin receptor	3667	3643	Gene	Gene	IRS-2|compound|START_ENTITY IRS-2|nmod|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
12493740	0	IRS-1	152,157	insulin_receptor	34,50	IRS-1	insulin receptor	3667	3643	Gene	Gene	IRS-2|compound|START_ENTITY association|nmod|IRS-2 disrupting|dobj|association signaling|advcl|disrupting 3-kinase/Akt|acl|signaling substrate|dep|3-kinase/Akt substrate|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
15069075	0	IRS-1	89,94	insulin_receptor	132,148	IRS-1	insulin receptor	3667	3643	Gene	Gene	insulin_receptor_substrate-1|appos|START_ENTITY Ser318|nmod|insulin_receptor_substrate-1 phosphorylation|nmod|Ser318 attenuates|nsubj|phosphorylation attenuates|dobj|interaction interaction|nmod|END_ENTITY	Protein_kinase_C-zeta-induced phosphorylation of Ser318 in insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- attenuates the interaction with the insulin_receptor and the tyrosine phosphorylation of IRS-1 .
15590636	0	IRS-1	36,41	insulin_receptor	97,113	IRS-1	insulin receptor	3667	3643	Gene	Gene	G972R|compound|START_ENTITY causes|nsubj|G972R causes|nmod|END_ENTITY	Human insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- polymorphism G972R causes IRS-1 to associate with the insulin_receptor and inhibit receptor autophosphorylation .
15590636	0	IRS-1	69,74	insulin_receptor	97,113	IRS-1	insulin receptor	3667	3643	Gene	Gene	causes|xcomp|START_ENTITY causes|nmod|END_ENTITY	Human insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- polymorphism G972R causes IRS-1 to associate with the insulin_receptor and inhibit receptor autophosphorylation .
7593251	0	IRS-1	119,124	insulin_receptor	65,81	IRS-1	insulin receptor	3667	3643	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Combination of insulinomimetic agents H2O2 and vanadate enhances insulin_receptor mediated tyrosine phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase .
7593251	0	IRS-1	136,141	insulin_receptor	65,81	IRS-1	insulin receptor	3667	3643	Gene	Gene	association|compound|START_ENTITY leading|nmod|association IRS-1|acl|leading phosphorylation|nmod|IRS-1 phosphorylation|amod|END_ENTITY	Combination of insulinomimetic agents H2O2 and vanadate enhances insulin_receptor mediated tyrosine phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase .
7999100	0	IRS-1	97,102	insulin_receptor	22,38	IRS-1	insulin receptor	3667	3643	Gene	Gene	role|nmod|START_ENTITY makes|parataxis|role makes|nsubj|overexpression overexpression|nmod|END_ENTITY	The overexpression of insulin_receptor makes CHO cells resistant to the action of IGF-1 : role of IRS-1 .
8349691	0	IRS-1	50,55	insulin_receptor	23,39	IRS-1	insulin receptor	25467(Tax:10116)	24954(Tax:10116)	Gene	Gene	substrate|dobj|START_ENTITY substrate|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of the insulin_receptor substrate IRS-1 by casein kinase II .
8549754	0	IRS-1	96,101	insulin_receptor	52,68	IRS-1	insulin receptor	25467(Tax:10116)	24954(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Glucose - and insulin-induced phosphorylation of the insulin_receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets .
8646778	0	IRS-1	17,22	insulin_receptor	75,91	IRS-1	insulin receptor	3667	3643	Gene	Gene	domain|compound|START_ENTITY Structure|nmod|domain bound|nsubj|Structure bound|nmod|region region|nmod|END_ENTITY	Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin_receptor .
9346913	0	IRS-1	55,60	insulin_receptor	68,84	IRS-1	insulin receptor	3667	3643	Gene	Gene	do|dobj|START_ENTITY do|nmod|END_ENTITY	Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin_receptor .
9368067	1	IRS-1	87,92	insulin_receptor	161,177	IRS-1	insulin receptor	25467(Tax:10116)	24954(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY inhibits|nsubj|phosphorylation inhibits|dobj|region region|nmod|END_ENTITY	Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin_receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation .
11025561	0	IRS-1	70,75	insulin_receptor_substrate-1	40,68	IRS-1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular scanning for mutations in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene in Mexican Americans with Type_2_diabetes mellitus .
11317670	0	IRS-1	55,60	insulin_receptor_substrate-1	25,53	IRS-1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The G972R variant of the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene , body fat distribution and insulin-resistance .
15636429	0	IRS-1	55,60	insulin_receptor_substrate-1	25,53	IRS-1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The G972R variant of the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene is associated with insulin resistance in `` uncomplicated '' obese subjects evaluated by hyperinsulinemic-euglycemic_clamp .
16037106	0	IRS-1	51,56	insulin_receptor_substrate-1	21,49	IRS-1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene and the insulin_receptor_substrate-2 -LRB- IRS-2 -RRB- gene influence glucose homeostasis and body mass index in women with polycystic_ovary_syndrome and non-hyperandrogenic controls .
16284438	0	IRS-1	70,75	insulin_receptor_substrate-1	40,68	IRS-1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular scanning for mutations in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene in Turkish with type_2_diabetes_mellitus .
17020651	0	IRS-1	83,88	insulin_receptor_substrate-1	53,81	IRS-1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The influence of polymorphism the Gly972Arg variant insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene , and G-308A TNF-alpha gene on obesity and insulin resistance in children with obesity -RSB- .
7544300	0	IRS-1	52,57	insulin_receptor_substrate-1	22,50	IRS-1	insulin receptor substrate-1	25467(Tax:10116)	25467(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Effect of glucagon on insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- phosphorylation and association with phosphatidylinositol 3-kinase -LRB- PI 3-kinase -RRB- .
8167159	0	IRS-1	51,56	insulin_receptor_substrate-1	21,49	IRS-1	insulin receptor substrate-1	16367(Tax:10090)	16367(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the mouse insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene and complete sequence of mouse IRS-1 .
8739921	0	IRS-1	56,61	insulin_receptor_substrate-1	26,54	IRS-1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular scanning of the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene in Japanese patients with NIDDM : identification of five novel polymorphisms .
11208867	0	IRS-1	226,231	insulin_receptor_substrate_1	196,224	IRS-1	insulin receptor substrate 1	16367(Tax:10090)	16367(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription _ -LRB- STAT -RRB- - induced_STAT_inhibitor_1 -LRB- SSI-1 -RRB- / suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- inhibits insulin signal transduction pathway through modulating insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- phosphorylation .
11948686	0	IRS-1	35,40	mTOR	8,12	IRS-1	mTOR	3667	21977(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	Role of mTOR in the degradation of IRS-1 : regulation of PP2A activity .
16099428	0	IRS-1	83,88	mTOR	9,13	IRS-1	mTOR	3667	21977(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of mTOR and JNK in serine phosphorylation , translocation , and degradation of IRS-1 .
16530700	0	IRS-1	0,5	mTOR	37,41	IRS-1	mTOR	3667	21977(Tax:10090)	Gene	Gene	START_ENTITY|dep|auditing auditing|dep|effectiveness effectiveness|nmod|inhibitors inhibitors|compound|END_ENTITY	IRS-1 : auditing the effectiveness of mTOR inhibitors .
17721885	0	IRS-1	93,98	mTOR	85,89	IRS-1	mTOR	3667	21977(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells .
19561084	0	IRS-1	135,140	mTOR	159,163	IRS-1	mTOR	3667	21977(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|dobj|phosphorylation regulates|nmod|639 639|nmod|END_ENTITY	Raptor binds the SAIN -LRB- Shc and IRS-1 NPXY binding -RRB- domain of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- and regulates the phosphorylation of IRS-1 at Ser-636 / 639 by mTOR .
20555424	0	IRS-2	14,19	IGF-1_receptor	33,47	IRS-2	IGF-1 receptor	29376(Tax:10116)	25718(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of IRS-2 signaling by IGF-1_receptor in the diabetic rat heart .
14604813	0	IRS-2	11,16	INS-1	54,59	IRS-2	INS-1	8660	2305	Gene	Gene	expression|compound|START_ENTITY expression|nmod|beta-cells beta-cells|appos|END_ENTITY	Decreasing IRS-2 expression in pancreatic beta-cells -LRB- INS-1 -RRB- promotes apoptosis , which can be compensated for by introduction of IRS-4 expression .
15269981	0	IRS-2	15,20	INS-1	49,54	IRS-2	INS-1	29376(Tax:10116)	24505(Tax:10116)	Gene	Gene	Impairment|nmod|START_ENTITY Impairment|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	-LSB- Impairment of IRS-2 signaling in rat insulinoma INS-1 cells by nelfinavir -RSB- .
26919700	0	IRS-2	60,65	INS-1	69,74	IRS-2	INS-1	8660	2305	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 b Cells .
11522686	0	IRS-2	62,67	IRS-1	38,43	IRS-2	IRS-1	8660	3667	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic_ovary_syndrome .
11788357	0	IRS-2	68,73	IRS-1	60,65	IRS-2	IRS-1	29376(Tax:10116)	25467(Tax:10116)	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Calorie restriction increases muscle insulin action but not IRS-1 - , IRS-2 - , or phosphotyrosine-PI 3-kinase .
16921752	0	IRS-2	72,77	IRS-1	65,70	IRS-2	IRS-1	29376(Tax:10116)	25467(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	-LSB- Influence of chronic ethanol intake insulin sensitivity and IR , IRS-1 , IRS-2 mRNA expression of liver in male rats -RSB- .
16327801	0	IRS-2	41,46	TFE3	0,4	IRS-2	TFE3	384783(Tax:10090)	209446(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TFE3 transcriptionally activates hepatic IRS-2 , participates in insulin signaling and ameliorates diabetes .
8662806	0	IRS-2	45,50	insulin_receptor_substrate-2	15,43	IRS-2	insulin receptor substrate-2	8660	8660	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of insulin_receptor_substrate-2 -LRB- IRS-2 -RRB- with the insulin_and_insulin-like_growth_factor_I receptors .
9535722	0	IRS-2	76,81	phospholipase_C_gamma-1	42,65	IRS-2	phospholipase C gamma-1	8660	5335	Gene	Gene	association|compound|START_ENTITY association|amod|END_ENTITY	IL-13 induces tyrosine phosphorylation of phospholipase_C_gamma-1 following IRS-2 association in human monocytes : relationship with the inhibitory effect of IL-13 on ROI production .
12488959	0	IRS-3	52,57	insulin_receptor_substrate-3	22,50	IRS-3	insulin receptor substrate-3	442338	442338	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Absence of functional insulin_receptor_substrate-3 -LRB- IRS-3 -RRB- gene in humans .
22635093	0	IRS-3	114,119	insulin_receptor_substrate-3	84,112	IRS-3	insulin receptor substrate-3	442338	442338	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence for a negative association between schizophrenia and a polymorphism in the insulin_receptor_substrate-3 -LRB- IRS-3 -RRB- gene .
24967972	0	IRS-4	101,106	CTR1	71,75	IRS-4	CTR1	8471	1317	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4 .
21407155	0	IRS-4	34,39	insulin_receptor_substrate-4	4,32	IRS-4	insulin receptor substrate-4	8471	8471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The insulin_receptor_substrate-4 -LRB- IRS-4 -RRB- gene and schizophrenia : no evidence for a main genetic factor , however one report of a single schizophrenia patient with a mutation .
22167131	0	IRS-4	70,75	insulin_receptor_substrate-4	40,68	IRS-4	insulin receptor substrate-4	8471	8471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between body mass index and insulin_receptor_substrate-4 -LRB- IRS-4 -RRB- gene polymorphisms in patients with schizophrenia .
8491186	0	IRS1	82,86	GRB2	38,42	IRS1	GRB2	3667	2885	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc : implications for insulin control of ras signalling .
21289241	0	IRS1	55,59	S6K1	22,26	IRS1	S6K1	3667	6198	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired_glucose_tolerance_postpartum .
22005517	0	IRS1	21,25	Sam68	0,5	IRS1	Sam68	3667	10657	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sam68 interacts with IRS1 .
20444996	0	IRS1	46,50	UL44	108,112	IRS1	UL44	3077574(Tax:10359)	3077460(Tax:10359)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human_cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44 .
16128672	0	IRS1	22,26	insulin_receptor_substrate-1	28,56	IRS1	insulin receptor substrate-1	3667	3667	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	A novel regulation of IRS1 -LRB- insulin_receptor_substrate-1 -RRB- expression following short term insulin administration .
8477879	0	IRS1	41,45	insulin_receptor_substrate-1	6,34	IRS1	insulin receptor substrate-1	3667	3667	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human insulin_receptor_substrate-1 gene -LRB- IRS1 -RRB- : chromosomal localization to 2q35-q36 .1 and identification of a simple tandem repeat DNA polymorphism .
24451368	0	IRS1	131,135	insulin_receptor_substrate_1	101,129	IRS1	insulin receptor substrate 1	16367(Tax:10090)	16367(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Myostatin induces insulin resistance via Casitas_B-lineage_lymphoma_b -LRB- Cblb -RRB- - mediated degradation of insulin_receptor_substrate_1 -LRB- IRS1 -RRB- protein in response to high calorie diet intake .
18057093	0	IRS2	18,22	ATF3	31,35	IRS2	ATF3	29376(Tax:10116)	25389(Tax:10116)	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	The repression of IRS2 gene by ATF3 , a stress-inducible gene , contributes to pancreatic beta-cell apoptosis .
22560222	0	IRS2	0,4	FoxO1	44,49	IRS2	FoxO1	384783(Tax:10090)	56458(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action .
19875459	0	IRS2	39,43	ZBP89	72,77	IRS2	ZBP89	8660	7707	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Neuronal insulin_receptor_substrate_2 -LRB- IRS2 -RRB- expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter .
23775122	0	IRS2	32,36	angiotensin_II	50,64	IRS2	angiotensin II	29376(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|acl|activated activated|nmod|END_ENTITY	Serine phosphorylation sites on IRS2 activated by angiotensin_II and protein kinase C to induce selective insulin resistance in endothelial cells .
19875459	0	IRS2	39,43	insulin_receptor_substrate_2	9,37	IRS2	insulin receptor substrate 2	8660	8660	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Neuronal insulin_receptor_substrate_2 -LRB- IRS2 -RRB- expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter .
21104145	0	IRS4	38,42	insulin_receptor_substrate_4	8,36	IRS4	insulin receptor substrate 4	8471	8471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Porcine insulin_receptor_substrate_4 -LRB- IRS4 -RRB- gene : cloning , polymorphism and association study .
12504591	0	IRSp53	31,37	cdc42	87,92	IRSp53	cdc42	10458	998	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42 .
22179776	0	IRSp53	48,54	mDia1	0,5	IRSp53	mDia1	10458	13367(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|proteins proteins|compound|END_ENTITY	mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation .
12504591	0	IRSp53	31,37	shank1	57,63	IRSp53	shank1	10458	50944	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42 .
16681430	0	IRTA2	92,97	FcRH5	99,104	IRTA2	FcRH5	83416	83416	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
16681430	0	IRTA2	92,97	immunoglobulin_superfamily_receptor_translocation-associated_2	28,90	IRTA2	immunoglobulin superfamily receptor translocation-associated 2	83416	83416	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
17588661	0	IRp60	12,17	CD300a	4,10	IRp60	CD300a	11314	11314	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The CD300a -LRB- IRp60 -RRB- inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a -LRB- FcgammaRIIa -RRB- mediated signaling .
6363207	0	IS1	66,69	Leu_2	26,31	IS1	Leu 2	20493545	850342(Tax:4932)	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Regulation of yeast gene Leu_2 expression in Escherichia_coli by IS1 element -RSB- .
6282714	0	IS2	52,55	TRP5	74,78	IS2	TRP5	8381885(Tax:562)	852858(Tax:4932)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	DNA sequences flanking an E. _ coli insertion element IS2 in a cloned yeast TRP5 gene .
22977270	0	ISCU	55,59	HIF-1a	35,41	ISCU	HIF-1a	27247	3091	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a signaling axis HIF-1a / microRNA-210 / ISCU independent of SDH mutation that defines a subgroup of head and neck_paragangliomas .
25597503	0	ISCU	80,84	NFS1	56,60	ISCU	NFS1	23479	9054	Gene	Gene	thiols|amod|START_ENTITY enhances|nmod|thiols enhances|dobj|transfer transfer|nmod|persulfide persulfide|compound|END_ENTITY	Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols .
24573684	0	ISCU	109,113	iron-sulfur_cluster_scaffold_protein	71,107	ISCU	iron-sulfur cluster scaffold protein	27247	27247	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The presence of multiple cellular defects associated with a novel G50E iron-sulfur_cluster_scaffold_protein -LRB- ISCU -RRB- mutation leads to development of mitochondrial_myopathy .
17331979	0	ISD11	38,43	frataxin	14,22	ISD11	frataxin	57128	2395	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones .
18287095	0	ISG15	0,5	Nedd4	15,20	ISG15	Nedd4	9636	4734	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response .
11788588	0	ISG15	35,40	UBP43	0,5	ISG15	UBP43	100038882(Tax:10090)	24110(Tax:10090)	Gene	Gene	removes|dobj|START_ENTITY removes|nsubj|END_ENTITY	UBP43 -LRB- USP18 -RRB- specifically removes ISG15 from conjugated proteins .
20429933	0	ISG20L1	0,7	p53	13,16	ISG20L1	p53	64782	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy .
24630834	0	ISG54	0,5	TLR3	31,35	ISG54	TLR3	3433	7098	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	ISG54 and ISG56 are induced by TLR3 signaling in U373MG human astrocytoma cells : possible involvement in CXCL10 expression .
7529187	0	ISGF-3	64,70	interferon-stimulated_gene_factor-3	27,62	ISGF-3	interferon-stimulated gene factor-3	6773	6773	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Induction of expression of interferon-stimulated_gene_factor-3 -LRB- ISGF-3 -RRB- proteins by interferons .
9242679	0	ISGF3	131,136	p48	63,66	ISGF3	p48	6772	10379	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 .
7843405	0	ISGF3_gamma	49,60	IFN-beta	96,104	ISGF3 gamma	IFN-beta	16391(Tax:10090)	15977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	Possible involvement of the transcription factor ISGF3_gamma in virus-induced expression of the IFN-beta gene .
8990168	0	ISGF3gamma	53,63	p48	65,68	ISGF3gamma	p48	16391(Tax:10090)	16391(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interferon_gamma-induced transcription of the murine ISGF3gamma -LRB- p48 -RRB- gene is mediated by novel factors .
9207073	0	ISGF3gamma	37,47	p48	32,35	ISGF3gamma	p48	16391(Tax:10090)	16391(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The interferon-inducible murine p48 -LRB- ISGF3gamma -RRB- gene is regulated by protooncogene c-myc .
22303449	0	ISL1	0,4	FGF10	24,29	ISL1	FGF10	3670	2255	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	ISL1 directly regulates FGF10 transcription during human cardiac outflow formation .
24751901	0	ISL1	59,63	Islet-1	65,72	ISL1	Islet-1	3670	3670	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the LIM homeobox domain transcription factor ISL1 -LRB- Islet-1 -RRB- is frequent in rhabdomyosarcoma but very limited in other soft tissue sarcoma types .
10512678	0	ISLR	16,20	immunoglobulin_superfamily_containing_leucine-rich_repeat	22,79	ISLR	immunoglobulin superfamily containing leucine-rich repeat	26968(Tax:10090)	26968(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Human and mouse ISLR -LRB- immunoglobulin_superfamily_containing_leucine-rich_repeat -RRB- genes : genomic structure and tissue expression .
26752192	0	ISO-1	19,24	MIF	4,7	ISO-1	MIF	10209	4282	Gene	Gene	Inflammation|compound|START_ENTITY Inflammation|compound|END_ENTITY	The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD .
17491017	0	ISW2	20,24	Dpb4	4,8	ISW2	Dpb4	854480(Tax:4932)	851699(Tax:4932)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The Dpb4 subunit of ISW2 is anchored to extranucleosomal DNA .
22167269	0	ISWI	32,36	ATPase	37,43	ISWI	ATPase	6594	1769	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry .
17760996	0	ISWI	29,33	GCN5	37,41	ISWI	GCN5	36390(Tax:7227)	39431(Tax:7227)	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|nmod|END_ENTITY	Site-specific acetylation of ISWI by GCN5 .
9730600	0	ISWI	86,90	hSNF2H	40,46	ISWI	hSNF2H	36390(Tax:7227)	8467	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Cloning and mapping of SMARCA5 encoding hSNF2H , a novel human homologue of Drosophila ISWI .
25777360	0	ITCH	0,4	SIRT6	15,20	ITCH	SIRT6	16396(Tax:10090)	50721(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice .
26796253	0	ITCH	30,34	Thioredoxin-Interacting_Protein	50,81	ITCH	Thioredoxin-Interacting Protein	16396(Tax:10090)	56338(Tax:10090)	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting_Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity .
22009753	0	ITCH	27,31	lysosomal-associated_protein_multispanning_transmembrane_5	40,98	ITCH	lysosomal-associated protein multispanning transmembrane 5	83737	7805	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	HECT-type ubiquitin ligase ITCH targets lysosomal-associated_protein_multispanning_transmembrane_5 -LRB- LAPTM5 -RRB- and prevents LAPTM5-mediated cell death .
24855211	0	ITD	15,18	FLT3	10,14	ITD	FLT3	2322	2322	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of FLT3 -LRB- ITD -RRB- mutant allele level on relapse risk in intermediate-risk acute_myeloid_leukemia .
25776570	0	ITF	49,52	intestinal_trefoil_factor	22,47	ITF	intestinal trefoil factor	7033	7033	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Protective effects of intestinal_trefoil_factor -LRB- ITF -RRB- on gastric mucosal epithelium through activation of extracellular_signal-regulated_kinase_1 / 2 -LRB- ERK1/2 -RRB- .
12663147	0	ITF	53,56	trefoil_factor_3	36,52	ITF	trefoil factor 3	7033	7033	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Ontogeny and prenatal expression of trefoil_factor_3 / ITF in the human intestine .
20603605	0	ITF2	0,4	CXCR4	20,25	ITF2	CXCR4	6925	7852	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	ITF2 is a target of CXCR4 in MDA-MB-231_breast_cancer cells and is associated with reduced survival in estrogen receptor-negative breast_cancer .
12392762	0	ITGA11	45,51	integrin_alpha11	22,38	ITGA11	integrin alpha11	22801	22801	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the human integrin_alpha11 gene -LRB- ITGA11 -RRB- and its promoter .
26559905	0	ITGA4	7,12	CD49d	0,5	ITGA4	CD49d	3676	3676	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CD49d -LRB- ITGA4 -RRB- expression is a predictor of time to first treatment in patients with chronic_lymphocytic_leukaemia and mutated IGHV status .
10403775	0	ITGA7	134,139	integrin_alpha7	112,127	ITGA7	integrin alpha7	3679	3679	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure , genetic localization , and identification of the cardiac and skeletal muscle transcripts of the human integrin_alpha7 gene -LRB- ITGA7 -RRB- .
15579315	0	ITGA8	87,92	integrin_subunit_alpha8	57,80	ITGA8	integrin subunit alpha8	8516	8516	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and sequence variation of the human integrin_subunit_alpha8 gene -LRB- ITGA8 -RRB- .
12020947	0	ITGAL	45,50	CD11a	52,57	ITGAL	CD11a	3683	3683	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Age-dependent DNA methylation changes in the ITGAL -LRB- CD11a -RRB- promoter .
19129174	0	ITGAM	79,84	integrin-alpha-M	61,77	ITGAM	integrin-alpha-M	3684	3684	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of imputation-based association in and around the integrin-alpha-M -LRB- ITGAM -RRB- gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic_lupus_erythematosus -LRB- SLE -RRB- .
26766915	0	ITGB1	88,93	MiR-29c	0,7	ITGB1	MiR-29c	3688	407026	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-29c inhibits cell growth , invasion , and migration of pancreatic_cancer by targeting ITGB1 .
20017903	0	ITGB1BP2	14,22	Melusin	0,7	ITGB1BP2	Melusin	26548	26548	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Melusin gene -LRB- ITGB1BP2 -RRB- nucleotide variations study in hypertensive and cardiopathic patients .
25322676	0	ITGB2	6,11	CD18	0,4	ITGB2	CD18	3689	3689	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CD18 -LRB- ITGB2 -RRB- expression in chronic_lymphocytic_leukaemia is regulated by DNA methylation-dependent and - independent mechanisms .
10512685	0	ITGB2	49,54	beta-2	27,33	ITGB2	beta-2	3689	10242	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A missense mutation in the beta-2 integrin gene -LRB- ITGB2 -RRB- causes canine leukocyte_adhesion_deficiency .
19544212	0	ITGB2	61,66	integrin_beta_2	44,59	ITGB2	integrin beta 2	102400120	102400120	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of novel allelic variants of integrin_beta_2 -LRB- ITGB2 -RRB- gene and screening for Bubaline leukocyte_adhesion_deficiency syndrome in Indian water buffaloes -LRB- Bubalus_bubalis -RRB- .
15705408	0	ITGB3	40,45	PLA2	15,19	ITGB3	PLA2	3690	5319	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	Association of PLA2 polymorphism of the ITGB3 gene with early fetal loss .
23981581	0	ITGB3	97,102	let-7c	9,15	ITGB3	let-7c	3690	406885	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA let-7c inhibits migration and invasion of human non-small_cell_lung_cancer by targeting ITGB3 and MAP4K3 .
15009117	0	ITGB4	120,125	integrin_beta4	99,113	ITGB4	integrin beta4	3691	3691	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pyloric_atresia-junctional_epidermolysis_bullosa_syndrome showing novel 594insC/Q425P mutations in integrin_beta4 gene -LRB- ITGB4 -RRB- .
9892956	0	ITGB4	97,102	integrin_beta4	76,90	ITGB4	integrin beta4	3691	3691	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pyloric_atresia-junctional_epidermolysis_bullosa_syndrome : mutations in the integrin_beta4 gene -LRB- ITGB4 -RRB- in two unrelated patients with mild disease .
9194858	0	ITGB4	50,55	integrin_beta_4	28,43	ITGB4	integrin beta 4	3691	3691	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the integrin_beta_4 gene -LRB- ITGB4 -RRB- : a homozygous splice-site mutation in a patient with junctional_epidermolysis_bullosa associated with pyloric_atresia .
25531330	0	ITGb4	21,26	SYK	0,3	ITGb4	SYK	3691	6850	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	SYK interaction with ITGb4 suppressed by Epstein-Barr_virus LMP2A modulates migration and invasion of nasopharyngeal_carcinoma cells .
18226209	0	ITIH	71,75	Inter-alpha-trypsin_inhibitor_heavy_chain	28,69	ITIH	Inter-alpha-trypsin inhibitor heavy chain	3697	3697	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Frequent expression loss of Inter-alpha-trypsin_inhibitor_heavy_chain -LRB- ITIH -RRB- genes in multiple human solid_tumors : a systematic expression analysis .
8797089	0	ITIHL1	122,128	IHRP	110,114	ITIHL1	IHRP	3700	3700	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene -LRB- ITIHL1 -RRB- .
7587397	0	ITIHL1	88,94	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	17,81	ITIHL1	inter-alpha-trypsin inhibitor family heavy chain-related protein	3700	3700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein gene -LRB- ITIHL1 -RRB- to human chromosome 3p21 -- > p14 .
8797089	0	ITIHL1	122,128	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	44,108	ITIHL1	inter-alpha-trypsin inhibitor family heavy chain-related protein	3700	3700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene -LRB- ITIHL1 -RRB- .
8893810	0	ITK	61,64	IL-2-inducible_T-cell_kinase	26,54	ITK	IL-2-inducible T-cell kinase	3702	3702	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization of the human IL-2-inducible_T-cell_kinase gene -LRB- ITK -RRB- to chromosome band 5q34 and the mouse gene -LRB- Itk -RRB- to chromosome 15 by fluorescence in situ hybridization .
26950250	0	ITK	111,114	Interleukin-2_Inducible_T-Cell_Kinase	72,109	ITK	Interleukin-2 Inducible T-Cell Kinase	3702	3702	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2_Inducible_T-Cell_Kinase -LRB- ITK -RRB- Inhibitors .
17420479	0	ITK	66,69	SLP-76	0,6	ITK	SLP-76	3702	3937	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T_cell_antigen_receptor-induced association between SLP-76 and ITK .
17420479	0	ITK	66,69	SLP-76	130,136	ITK	SLP-76	3702	3937	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T_cell_antigen_receptor-induced association between SLP-76 and ITK .
23293025	0	ITK	17,20	SLP-76	128,134	ITK	SLP-76	3702	3937	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|dep|SYK SYK|acl:relcl|dependent dependent|nmod|END_ENTITY	Signaling of the ITK -LRB- interleukin 2-inducible T cell kinase -RRB- - SYK -LRB- spleen tyrosine kinase -RRB- fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70 .
23293025	0	ITK	17,20	SYK	61,64	ITK	SYK	3702	6850	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|dep|END_ENTITY	Signaling of the ITK -LRB- interleukin 2-inducible T cell kinase -RRB- - SYK -LRB- spleen tyrosine kinase -RRB- fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70 .
20305788	0	ITK	65,68	T_cell_specific_adapter_protein	0,31	ITK	T cell specific adapter protein	3702	9047	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	T_cell_specific_adapter_protein -LRB- TSAd -RRB- interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells .
9326591	0	ITK	51,54	inducible_T_cell_kinase	26,49	ITK	inducible T cell kinase	16428(Tax:10090)	16428(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Src-induced activation of inducible_T_cell_kinase -LRB- ITK -RRB- requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible_T_cell_kinase .
18223458	0	ITPA	48,52	inosine_triphosphatase	24,46	ITPA	inosine triphosphatase	3704	3704	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the inosine_triphosphatase -LRB- ITPA -RRB- gene : haplotype structure , haplotype-phenotype correlation and promoter function .
27062503	0	ITPR1	33,38	IRBIT	17,22	ITPR1	IRBIT	3708	10768	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Mutations in the IRBIT domain of ITPR1 are a frequent cause of autosomal dominant nonprogressive congenital_ataxia .
10072581	0	ITSN	80,84	intersectin	62,73	ITSN	intersectin	6453	6453	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure , sequence , and refined mapping of the human intersectin gene -LRB- ITSN -RRB- , which encompasses 250 kb on chromosome 21q22 .1 -- > q22 .2 .
9799604	0	ITSN	37,41	intersectin	24,35	ITSN	intersectin	6453	6453	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Two isoforms of a human intersectin -LRB- ITSN -RRB- protein are produced by brain-specific alternative splicing in a stop codon .
18298590	0	ITSN-1	0,6	DAB-1	95,100	ITSN-1	DAB-1	178491(Tax:6239)	174323(Tax:6239)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1 .
17576084	0	IVD	65,68	isovaleryl-CoA_dehydrogenase	35,63	IVD	isovaleryl-CoA dehydrogenase	3712	3712	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Different spectrum of mutations of isovaleryl-CoA_dehydrogenase -LRB- IVD -RRB- gene in Korean patients with isovaleric_acidemia .
20139304	0	IWS1	12,16	BES1	53,57	IWS1	BES1	840105(Tax:3702)	838518(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arabidopsis IWS1 interacts with transcription factor BES1 and is involved in plant steroid hormone brassinosteroid regulated gene expression .
20146743	0	IZH2	60,64	eos1	43,47	IZH2	eos1	854160(Tax:4932)	855644(Tax:4932)	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	Multicopy suppression of oxidant-sensitive eos1 mutation by IZH2 in Saccharomyces_cerevisiae and the involvement of Eos1 in zinc homeostasis .
25053419	0	I_insulin-like_growth_factor_receptor	39,76	FOXO1/3/4	116,125	I insulin-like growth factor receptor	FOXO1/3/4	3480	2308;2309;4303	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	GSK3 protein positively regulates type I_insulin-like_growth_factor_receptor through forkhead transcription factors FOXO1/3/4 .
18809274	0	I_kappaB_alpha	65,79	NF-kappaB	22,31	I kappaB alpha	NF-kappaB	4792	4790	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Paeoniflorin suppress NF-kappaB activation through modulation of I_kappaB_alpha and enhances 5-fluorouracil-induced apoptosis in human gastric_carcinoma cells .
8806678	0	I_kappa_B-alpha	88,103	Bcl-2	0,5	I kappa B-alpha	Bcl-2	396093(Tax:9031)	396282(Tax:9031)	Gene	Gene	effects|nmod|START_ENTITY have|dobj|effects have|nsubj|END_ENTITY	Bcl-2 and CrmA have different effects on transformation , apoptosis and the stability of I_kappa_B-alpha in chicken spleen cells transformed by temperature-sensitive v-Rel oncoproteins .
8262046	0	I_kappa_B-alpha	43,58	MAD3	59,63	I kappa B-alpha	MAD3	4792	4792	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Promoter analysis of the gene encoding the I_kappa_B-alpha / MAD3 inhibitor of NF-kappa_B : positive regulation by members of the rel/NF-kappa _ B family .
8797825	0	I_kappa_B-alpha	28,43	NF-kappa_B	54,64	I kappa B-alpha	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY activates|nsubj|phosphorylation activates|dobj|END_ENTITY	Tyrosine phosphorylation of I_kappa_B-alpha activates NF-kappa_B without proteolytic degradation of I_kappa_B-alpha .
8622692	0	I_kappa_B_alpha	32,47	Casein_kinase_II	0,16	I kappa B alpha	Casein kinase II	4792	1457	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Casein_kinase_II phosphorylates I_kappa_B_alpha at S-283 , S-289 , S-293 , and T-291 and is required for its degradation .
7532282	0	I_kappa_B_alpha	135,150	MAD-3	151,156	I kappa B alpha	MAD-3	4792	4792	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Transcription-independent turnover of I_kappa_B_alpha during monocyte adherence : implications for a translational component regulating I_kappa_B_alpha / MAD-3 mRNA levels .
10582246	0	I_kappa_B_alpha	82,97	NF-kappa_B	11,21	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	proteolysis|nmod|START_ENTITY induced|dobj|proteolysis induced|nsubj|Control Control|nmod|activation activation|amod|END_ENTITY	Control of NF-kappa_B transcriptional activation by signal induced proteolysis of I_kappa_B_alpha .
10779782	0	I_kappa_B_alpha	21,36	NF-kappa_B	82,92	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	mechanisms|compound|START_ENTITY switch|nmod|mechanisms mediates|nsubj|switch mediates|dobj|activation activation|amod|END_ENTITY	A switch in distinct I_kappa_B_alpha degradation mechanisms mediates constitutive NF-kappa_B activation in mature B cells .
10882738	0	I_kappa_B_alpha	13,28	NF-kappa_B	40,50	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|amod|binding binding|nmod|dimers dimers|amod|END_ENTITY	Mechanism of I_kappa_B_alpha binding to NF-kappa_B dimers .
11780335	0	I_kappa_B_alpha	45,60	NF-kappa_B	15,25	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	LMP1 activates NF-kappa_B via degradation of I_kappa_B_alpha in nasopharyngeal_carcinoma cells .
12193729	0	I_kappa_B_alpha	70,85	NF-kappa_B	14,24	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	mutant|nmod|START_ENTITY Inhibition|nmod|mutant Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of NF-kappa_B activity by a membrane-transducing mutant of I_kappa_B_alpha .
12244195	0	I_kappa_B_alpha	54,69	NF-kappa_B	0,10	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	neutrophils|nmod|START_ENTITY regulation|nmod|neutrophils regulation|amod|END_ENTITY	NF-kappa_B regulation in human neutrophils by nuclear I_kappa_B_alpha : correlation to apoptosis .
12618762	0	I_kappa_B_alpha	50,65	NF-kappa_B	27,37	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	M|compound|START_ENTITY activity|nmod|M activity|amod|END_ENTITY	Inhibition of constitutive NF-kappa_B activity by I_kappa_B_alpha M suppresses tumorigenesis .
12711606	0	I_kappa_B_alpha	75,90	NF-kappa_B	28,38	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Hydrogen_peroxide activates NF-kappa_B through tyrosine phosphorylation of I_kappa_B_alpha and serine phosphorylation of p65 : evidence for the involvement of I_kappa_B_alpha kinase and Syk protein-tyrosine kinase .
12917341	0	I_kappa_B_alpha	151,166	NF-kappa_B	46,56	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	reappearance|nmod|START_ENTITY associated|nmod|reappearance associated|nsubjpass|activation activation|amod|END_ENTITY	Potentiation of tumor necrosis factor-induced NF-kappa_B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I_kappa_B_alpha .
12963487	0	I_kappa_B_alpha	84,99	NF-kappa_B	18,28	I kappa B alpha	NF-kappa B	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY cells|nmod|cleavage END_ENTITY|nmod|cells	Genistein reduces NF-kappa_B in T_lymphoma cells via a caspase-mediated cleavage of I_kappa_B_alpha .
15265936	0	I_kappa_B_alpha	123,138	NF-kappa_B	65,75	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase inhibition|nmod|activation abrogates|nmod|inhibition abrogates|dobj|activation activation|amod|END_ENTITY	Cyclooxygenase _ -LRB- COX -RRB- -2 inhibitor celecoxib abrogates TNF-induced NF-kappa_B activation through inhibition of activation of I_kappa_B_alpha kinase and Akt in human non-small_cell_lung_carcinoma : correlation with suppression of COX-2 synthesis .
15596146	0	I_kappa_B_alpha	53,68	NF-kappa_B	14,24	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|nmod|form	Inhibition of NF-kappa_B by a cell permeable form of I_kappa_B_alpha induces apoptosis in eosinophils .
15950952	0	I_kappa_B_alpha	143,158	NF-kappa_B	25,35	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	stabilizes|dobj|START_ENTITY prevents|parataxis|stabilizes prevents|dobj|activation activation|amod|END_ENTITY	HDAC inhibition prevents NF-kappa_B activation by suppressing proteasome activity : down-regulation of proteasome subunit expression stabilizes I_kappa_B_alpha .
16081774	0	I_kappa_B_alpha	94,109	NF-kappa_B	57,67	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	degradation|compound|START_ENTITY independent|nmod|degradation independent|amod|END_ENTITY	A helminth glycan induces APC maturation via alternative NF-kappa_B activation independent of I_kappa_B_alpha degradation .
7479848	0	I_kappa_B_alpha	22,37	NF-kappa_B	64,74	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|compound|START_ENTITY marks|nsubj|phosphorylation marks|dobj|inhibitor inhibitor|amod|END_ENTITY	Stimulation-dependent I_kappa_B_alpha phosphorylation marks the NF-kappa_B inhibitor for degradation via the ubiquitin-proteasome pathway .
7629157	0	I_kappa_B_alpha	83,98	NF-kappa_B	14,24	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY involves|dobj|phosphorylation involves|nsubj|Activation Activation|nmod|END_ENTITY	Activation of NF-kappa_B by phosphatase inhibitors involves the phosphorylation of I_kappa_B_alpha at phosphatase 2A-sensitive sites .
7675460	0	I_kappa_B_alpha	60,75	NF-kappa_B	14,24	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	degradation|nmod|START_ENTITY involves|dobj|degradation involves|nsubj|Activation Activation|nmod|Rel Rel|compound|END_ENTITY	Activation of NF-kappa_B / Rel by Tax involves degradation of I_kappa_B_alpha and is blocked by a proteasome inhibitor .
7739549	0	I_kappa_B_alpha	50,65	NF-kappa_B	133,143	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	expression|nmod|START_ENTITY regulates|nsubj|expression regulates|dobj|activities activities|nmod|END_ENTITY	Inducible nuclear expression of newly synthesized I_kappa_B_alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa_B .
7739562	0	I_kappa_B_alpha	40,55	NF-kappa_B	81,91	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	domain|nmod|START_ENTITY Coupling|nmod|domain Coupling|nmod|activation activation|amod|END_ENTITY	Coupling of a signal response domain in I_kappa_B_alpha to multiple pathways for NF-kappa_B activation .
7775482	0	I_kappa_B_alpha	31,46	NF-kappa_B	86,96	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	Induction|nmod|START_ENTITY mediates|nsubj|Induction mediates|dobj|inhibition inhibition|nmod|END_ENTITY	Induction and stabilization of I_kappa_B_alpha by nitric_oxide mediates inhibition of NF-kappa_B .
7884865	0	I_kappa_B_alpha	64,79	NF-kappa_B	16,26	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	LMP-1 activates NF-kappa_B by targeting the inhibitory molecule I_kappa_B_alpha .
7891711	0	I_kappa_B_alpha	23,38	NF-kappa_B	69,79	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	organization|nmod|START_ENTITY organization|nmod|p65 p65|amod|END_ENTITY	Domain organization of I_kappa_B_alpha and sites of interaction with NF-kappa_B p65 .
7925301	0	I_kappa_B_alpha	59,74	NF-kappa_B	121,131	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	complexes|nmod|START_ENTITY interactions|nmod|complexes determine|nsubj|interactions determine|dobj|pools pools|nmod|activity activity|amod|END_ENTITY	Differential interactions of Rel-NF-kappa_B complexes with I_kappa_B_alpha determine pools of constitutive and inducible NF-kappa_B activity .
7935451	0	I_kappa_B_alpha	112,127	NF-kappa_B	53,63	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY involves|dobj|phosphorylation mediated|parataxis|involves mediated|nsubj|activation activation|nmod|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
7991551	0	I_kappa_B_alpha	29,44	NF-kappa_B	89,99	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY sufficient|nsubj|phosphorylation sufficient|nmod|dissociation dissociation|nmod|END_ENTITY	Inducible phosphorylation of I_kappa_B_alpha is not sufficient for its dissociation from NF-kappa_B and is inhibited by protease inhibitors .
8096091	0	I_kappa_B_alpha	44,59	NF-kappa_B	0,10	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	NF-kappa_B controls expression of inhibitor I_kappa_B_alpha : evidence for an inducible autoregulatory pathway .
8164680	0	I_kappa_B_alpha	9,24	NF-kappa_B	69,79	I kappa B alpha	NF-kappa B	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY responsible|nsubj|degradation responsible|nmod|activity activity|amod|END_ENTITY	Enhanced I_kappa_B_alpha degradation is responsible for constitutive NF-kappa_B activity in mature murine B-cell lines .
8223478	0	I_kappa_B_alpha	44,59	NF-kappa_B	19,29	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|control control|nmod|END_ENTITY	In vivo control of NF-kappa_B activation by I_kappa_B_alpha .
8255759	0	I_kappa_B_alpha	33,48	NF-kappa_B	149,159	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	MAD3|appos|START_ENTITY degradation|nmod|MAD3 steps|nsubj|degradation steps|nmod|activation activation|nmod|END_ENTITY	Proteolytic degradation of MAD3 -LRB- I_kappa_B_alpha -RRB- and enhanced processing of the NF-kappa_B precursor p105 are obligatory steps in the activation of NF-kappa_B .
8497253	0	I_kappa_B_alpha	76,91	NF-kappa_B	109,119	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY necrosis|nmod|phosphorylation necrosis|parataxis|mechanism mechanism|nmod|activation activation|amod|END_ENTITY	Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I_kappa_B_alpha : a mechanism for NF-kappa_B activation .
8642242	0	I_kappa_B_alpha	79,94	NF-kappa_B	137,147	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of endothelial cell activation by adenovirus-mediated expression of I_kappa_B_alpha , an inhibitor of the transcription factor NF-kappa_B .
8758892	0	I_kappa_B_alpha	105,120	NF-kappa_B	20,30	I kappa B alpha	NF-kappa B	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY apoptosis|dep|activation inducing|dobj|apoptosis END_ENTITY|parataxis|inducing	TGF_beta_1 inhibits NF-kappa_B / Rel activity inducing apoptosis of B cells : transcriptional activation of I_kappa_B_alpha .
9057089	0	I_kappa_B_alpha	24,39	NF-kappa_B	69,79	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	localization|nmod|START_ENTITY promotes|nsubj|localization promotes|dobj|transport transport|nmod|END_ENTITY	Nuclear localization of I_kappa_B_alpha promotes active transport of NF-kappa_B from the nucleus to the cytoplasm .
9338014	0	I_kappa_B_alpha	155,170	NF-kappa_B	0,10	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	cDNA|compound|START_ENTITY transfer|nmod|cDNA cells|nmod|transfer responses|nmod|cells suppression|nmod|responses END_ENTITY|dep|suppression	NF-kappa_B as a target for anti-inflammatory gene therapy : suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of I_kappa_B_alpha cDNA .
9442373	0	I_kappa_B_alpha	37,52	NF-kappa_B	14,24	I kappa B alpha	NF-kappa B	4792	4790	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of NF-kappa_B activity by I_kappa_B_alpha and I_kappa_B_beta stability .
16540234	0	I_kappa_B_alpha	32,47	NFKBIA	54,60	I kappa B alpha	NFKBIA	4792	4792	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Haplotypic structure across the I_kappa_B_alpha gene -LRB- NFKBIA -RRB- and association with multiple_myeloma .
12429743	0	I_kappa_B_alpha	28,43	NF_kappa_B	54,64	I kappa B alpha	NF kappa B	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY activates|nsubj|phosphorylation activates|dobj|END_ENTITY	Tyrosine phosphorylation of I_kappa_B_alpha activates NF_kappa_B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation .
14690537	0	I_kappa_B_alpha	84,99	NF_kappa_B	123,133	I kappa B alpha	NF kappa B	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Protection by pioglitazone in the MPTP model of Parkinson 's _ disease correlates with I_kappa_B_alpha induction and block of NF_kappa_B and iNOS activation .
7488149	0	I_kappa_B_alpha	97,112	NF_kappa_B	18,28	I kappa B alpha	NF kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY inhibiting|dobj|phosphorylation blocks|advcl|inhibiting blocks|dobj|activation activation|compound|END_ENTITY	Cupric ion blocks NF_kappa_B activation through inhibiting the signal-induced phosphorylation of I_kappa_B_alpha .
10713713	0	I_kappa_B_alpha	27,42	c-Rel	87,92	I kappa B alpha	c-Rel	4792	5966	Gene	Gene	determinants|nmod|START_ENTITY determinants|amod|necessary necessary|nmod|regulation regulation|nmod|END_ENTITY	N-terminal determinants of I_kappa_B_alpha necessary for the cytoplasmic regulation of c-Rel .
7636983	0	I_kappa_B_alpha	6,21	c-Rel	54,59	I kappa B alpha	c-Rel	4792	5966	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Avian I_kappa_B_alpha is transcriptionally induced by c-Rel and v-Rel with different kinetics .
7935451	0	I_kappa_B_alpha	112,127	c-rel	169,174	I kappa B alpha	c-rel	4792	5966	Gene	Gene	phosphorylation|nmod|START_ENTITY involves|dobj|phosphorylation mediated|parataxis|involves mediated|dobj|induction induction|nmod|gene gene|amod|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
8816457	0	I_kappa_B_beta	44,58	NF-kappa_B	87,97	I kappa B beta	NF-kappa B	4793	4790	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of unphosphorylated , newly synthesized I_kappa_B_beta in persistent activation of NF-kappa_B .
9442374	0	I_kappa_B_beta	38,52	NF-kappa_B	11,21	I kappa B beta	NF-kappa B	4793	4790	Gene	Gene	inhibitor|compound|START_ENTITY Control|nmod|inhibitor Control|nmod|activity activity|amod|END_ENTITY	Control of NF-kappa_B activity by the I_kappa_B_beta inhibitor .
9135156	0	I_kappa_B_epsilon	0,17	RelA	68,72	I kappa B epsilon	RelA	9641	5970	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	I_kappa_B_epsilon , a novel member of the I kappa B family , controls RelA and cRel NF-kappa_B activity .
11160335	0	I_kappa_B_kinase-2	25,43	NF-kappa_B	0,10	I kappa B kinase-2	NF-kappa B	3551	4790	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	NF-kappa_B regulation by I_kappa_B_kinase-2 in rheumatoid_arthritis synoviocytes .
17616684	0	I_kappa_B_kinase_alpha	95,117	mammalian_target_of_rapamycin	14,43	I kappa B kinase alpha	mammalian target of rapamycin	1147	2475	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of mammalian_target_of_rapamycin activity in PTEN-inactive prostate_cancer cells by I_kappa_B_kinase_alpha .
10934190	0	I_kappa_b_alpha	64,79	NF-kappa_B	29,39	I kappa b alpha	NF-kappa B	4792	4790	Gene	Gene	homologue|nmod|START_ENTITY Mechanism|nmod|homologue Mechanism|nmod|END_ENTITY	Mechanism of inactivation of NF-kappa_B by a viral homologue of I_kappa_b_alpha .
24185710	0	Ia1	21,24	Ets-1	62,67	Ia1	Ets-1	3642	2113	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Activation of the Ig Ia1 promoter by the transcription factor Ets-1 triggers Ig Ia1-Ca1 germline transcription in epithelial cancer cells .
12016466	0	Ia1	13,16	SP1	17,20	Ia1	SP1	3642	6667	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The collagen Ia1 SP1 polymorphism is associated with differences in ultrasound transmission velocity in the calcaneus in postmenopausal women .
26485593	0	Iba1	13,17	CD163	5,10	Iba1	CD163	199	9332	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Anti CD163 + , Iba1 + , and CD68 + Cells in the Adult Human Inner Ear : Normal Distribution of an Unappreciated Class of Macrophages/Microglia and Implications for Inflammatory Otopathology in Humans .
14756805	0	Iba1	38,42	fimbrin	52,59	Iba1	fimbrin	199	5357	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity .
8954078	0	Ice	25,28	Interferon-gamma	0,16	Ice	Interferon-gamma	834	3458	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interferon-gamma induces Ice gene expression and enhances cellular susceptibility to apoptosis in the U937 leukemia cell line .
16622178	0	Id-1	16,20	BMP-2	25,30	Id-1	BMP-2	15901(Tax:10090)	12156(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes .
18158619	0	Id-1	0,4	Bcl-2	15,20	Id-1	Bcl-2	3397	596	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast_cancer cells .
17448024	0	Id-1	27,31	EGFR	57,61	Id-1	EGFR	3397	1956	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of Id-1 and its association with EGFR in renal_cell_cancer .
21111670	0	Id-1	10,14	VEGF-C	69,75	Id-1	VEGF-C	3397	7424	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	Silencing Id-1 inhibits lymphangiogenesis through down-regulation of VEGF-C in oral_squamous_cell_carcinoma .
19201527	0	Id-1	0,4	androgen_receptor	98,115	Id-1	androgen receptor	3397	367	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Id-1 expression in androgen-dependent prostate_cancer is negatively regulated by androgen through androgen_receptor .
18158619	0	Id-1	0,4	p53	48,51	Id-1	p53	3397	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast_cancer cells .
17145808	0	Id-1	30,34	vascular_endothelial_growth_factor	84,118	Id-1	vascular endothelial growth factor	3397	7422	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|compound|END_ENTITY	Regulation of angiogenesis by Id-1 through hypoxia-inducible_factor-1alpha-mediated vascular_endothelial_growth_factor up-regulation in hepatocellular_carcinoma .
26084673	0	Id1	31,34	AKT	14,17	Id1	AKT	15901(Tax:10090)	11651(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of AKT signaling by Id1 controls t -LRB- 8 ; 21 -RRB- _ leukemia initiation and progression .
22245935	0	Id1	18,21	Akt	94,97	Id1	Akt	3397	207	Gene	Gene	Downregulation|nmod|START_ENTITY inhibits|nsubj|Downregulation inhibits|dobj|growth growth|nmod|pathway pathway|compound|END_ENTITY	Downregulation of Id1 by small interfering RNA in gastric_cancer inhibits cell growth via the Akt pathway .
15138269	0	Id1	63,66	INK4a	42,47	Id1	INK4a	3397	1029	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation of cellular senescence and p16 -LRB- INK4a -RRB- expression by Id1 and E47 proteins in human diploid fibroblast .
19486931	0	Id1	32,35	Inhibitor_of_differentiation_1	0,30	Id1	Inhibitor of differentiation 1	3397	3397	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibitor_of_differentiation_1 -LRB- Id1 -RRB- expression attenuates the degree of TiO2-induced cytotoxicity in H1299 non-small_cell_lung_cancer cells .
20235117	0	Id1	52,55	MyoD	43,47	Id1	MyoD	3397	4654	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Affinity of synthetic peptide fragments of MyoD for Id1 protein and their biological effects in several cancer cells .
24123584	0	Id1	84,87	MyoD	56,60	Id1	MyoD	3397	4654	Gene	Gene	development|nmod|START_ENTITY END_ENTITY|nmod|development	Structure activity relationships of peptidic analogs of MyoD for the development of Id1 inhibitors as antiproliferative agents .
25204555	0	Id1	15,18	PTK7	0,4	Id1	PTK7	15901(Tax:10090)	71461(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PTK7 regulates Id1 expression in CD44-high glioma cells .
19920078	0	Id1	22,25	Presenilin-1	0,12	Id1	Presenilin-1	15901(Tax:10090)	19164(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner .
20697353	0	Id1	0,3	RING1b	13,19	Id1	RING1b	3397	6045	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18 / Bmi-1 polycomb group complex .
18381431	0	Id1	14,17	SRC	32,35	Id1	SRC	3397	6714	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of Id1 expression by SRC : implications for targeting of the bone morphogenetic protein pathway in cancer .
19079362	0	Id1	44,47	Smad3	0,5	Id1	Smad3	3397	4088	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Smad3 mediates immediate early induction of Id1 by TGF-beta .
18413773	0	Id1	29,32	cyclin_D1	42,51	Id1	cyclin D1	3397	595	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	The helix-loop-helix protein Id1 requires cyclin_D1 to promote the proliferation of mammary epithelial cell acini .
23558671	0	Id1	71,74	inhibitor_of_differentiation-1	39,69	Id1	inhibitor of differentiation-1	15901(Tax:10090)	15901(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Spatial-temporal protein expression of inhibitor_of_differentiation-1 -LRB- Id1 -RRB- during fetal embryogenesis and in different mouse and human cancer types .
15138269	0	Id1	63,66	p16	38,41	Id1	p16	3397	1029	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of cellular senescence and p16 -LRB- INK4a -RRB- expression by Id1 and E47 proteins in human diploid fibroblast .
21933340	0	Id1	50,53	p16	64,67	Id1	p16	3397	1029	Gene	Gene	ubiquitination|nmod|START_ENTITY regulates|nsubj|ubiquitination regulates|dobj|expression expression|amod|END_ENTITY	Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence .
16547003	0	Id2	60,63	BMP4	0,4	Id2	BMP4	25587(Tax:10116)	25296(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	BMP4 regulates pancreatic progenitor cell expansion through Id2 .
17631285	0	Id2	27,30	Egr-1	62,67	Id2	Egr-1	3398	1958	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|nmod|END_ENTITY	Interleukin-1_beta-induced Id2 gene expression is mediated by Egr-1 in vascular smooth muscle cells .
20453161	0	Id2	14,17	Gfi-1	32,37	Id2	Gfi-1	15902(Tax:10090)	14581(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid development .
16772532	0	Id2	183,186	Mammalian_target_of_rapamycin	0,29	Id2	Mammalian target of rapamycin	3398	2475	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Mammalian_target_of_rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional differentiation through Id2 .
24980046	0	Id2	87,90	Mtg16	19,24	Id2	Mtg16	3398	863	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2 .
23033267	0	Id2	61,64	STAT5	23,28	Id2	STAT5	3398	6776	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development .
26175937	0	Id2	21,24	Snail	0,5	Id2	Snail	3398	6615	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Snail interacts with Id2 in the regulation of TNF-a-induced cancer cell invasion and migration in OSCC .
19137015	0	Id2	23,26	TGF-beta	0,8	Id2	TGF-beta	25587(Tax:10116)	59086(Tax:10116)	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	TGF-beta repression of Id2 induces apoptosis in gut epithelial cells .
16223775	0	Id2	37,40	TGF-beta1	55,64	Id2	TGF-beta1	3398	7040	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Differential involvement of PU .1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment .
22172709	0	Id2	78,81	inhibitor_of_DNA_binding_2	50,76	Id2	inhibitor of DNA binding 2	25587(Tax:10116)	25587(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Developmental changes and subcellular location in inhibitor_of_DNA_binding_2 -LRB- Id2 -RRB- immunoreactivity in the rat Corpus callosum .
11278691	0	Id2	14,17	insulin-like_growth_factor_I_receptor	41,78	Id2	insulin-like growth factor I receptor	15902(Tax:10090)	16001(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of Id2 gene expression by the insulin-like_growth_factor_I_receptor requires signaling by phosphatidylinositol_3-kinase .
21608079	0	Id2	23,26	p53	0,3	Id2	p53	3398	7157	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells .
23342268	0	Id3	79,82	CDKN1B	108,114	Id3	CDKN1B	3399	1027	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Id1 and Id3 expression is associated with increasing grade of prostate_cancer : Id3 preferentially regulates CDKN1B .
21857655	0	Id3	70,73	E2A	47,50	Id3	E2A	15903(Tax:10090)	21423(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells .
19618124	0	Id3	43,46	Inhibitor_of_DNA_binding_3	15,41	Id3	Inhibitor of DNA binding 3	3399	3399	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Inhibitor_of_DNA_binding_3 -LRB- Id3 -RRB- with Gut-enriched Kr ppel-like factor -LRB- GKLF -RRB- and p53 regulates proliferation of vascular smooth muscle cells .
19458195	0	Id3	0,3	Pax7	42,46	Id3	Pax7	15903(Tax:10090)	18509(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells .
26135667	0	Id3	38,41	S100A8	21,27	Id3	S100A8	15903(Tax:10090)	20201(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Inflammation-induced S100A8 activates Id3 and promotes colorectal_tumorigenesis .
23042815	0	Id3	8,11	VCAM-1	22,28	Id3	VCAM-1	15903(Tax:10090)	22329(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Loss of Id3 increases VCAM-1 expression , macrophage accumulation , and atherogenesis in Ldlr - / - mice .
16449966	0	Id3	0,3	caspase-3	14,23	Id3	caspase-3	3399	836	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Id3 induces a caspase-3 - and -9 - dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes .
9016574	0	Id3	49,52	muscle-specific	14,29	Id3	muscle-specific	3399	27335	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of muscle-specific gene expression by Id3 : requirement of the C-terminal region of the protein for stable expression and function .
9543182	0	Idd10	49,54	Idd3	44,48	Idd10	Idd3	110712(Tax:10090)	110655(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Pancreatic IL-10 induces diabetes in NOD.B6 Idd3 Idd10 mice .
9543182	0	Idd3	44,48	Idd10	49,54	Idd3	Idd10	110655(Tax:10090)	110712(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Pancreatic IL-10 induces diabetes in NOD.B6 Idd3 Idd10 mice .
17785827	0	Idd6	26,30	TLR1	40,44	Idd6	TLR1	107835(Tax:10090)	21897(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	The type 1 diabetes locus Idd6 controls TLR1 expression .
26582899	0	Idol	24,28	LDL_receptor	44,56	Idol	LDL receptor	218203(Tax:10090)	16835(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	The E3 ubiquitin ligase Idol controls brain LDL_receptor expression , ApoE clearance , and Ab_amyloidosis .
24454794	0	Idursulfase	55,66	iduronate-2-sulfatase	32,53	Idursulfase	iduronate-2-sulfatase	3423	3423	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant human iduronate-2-sulfatase -LRB- Idursulfase -RRB- on growth in young patients with mucopolysaccharidosis_type_II .
14764608	0	Ifi202	36,42	Interleukin-6	0,13	Ifi202	Interleukin-6	26388(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-6 induces expression of Ifi202 , an interferon-inducible candidate gene for lupus susceptibility .
17947638	0	Ifng	27,31	CD4	54,57	Ifng	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|cells cells|compound|END_ENTITY	Histone acetylation at the Ifng promoter in tolerized CD4 cells is associated with increased IFN-gamma expression during subsequent immunization to the same antigen .
19050254	0	Ifng	70,74	Th1	88,91	Ifng	Th1	3458	51497	Gene	Gene	locus|compound|START_ENTITY complexes|nmod|locus removal|nmod|complexes drives|nsubj|removal drives|dobj|differentiation differentiation|amod|END_ENTITY	T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation .
20027288	0	Ifng	27,31	Th1	76,79	Ifng	Th1	15978(Tax:10090)	57314(Tax:10090)	Gene	Gene	GTPases|compound|START_ENTITY induces|dobj|GTPases induces|nmod|part part|nmod|response response|amod|END_ENTITY	Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic_asthma .
22685315	0	Ifng	17,21	Th1	36,39	Ifng	Th1	3458	51497	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function .
22851706	0	Ifng	90,94	Th1	98,101	Ifng	Th1	15978(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Cutting edge : influence of Tmevpg1 , a long intergenic noncoding RNA , on the expression of Ifng by Th1 cells .
25225667	0	Ifng	41,45	Th1	18,21	Ifng	Th1	3458	51497	Gene	Gene	Locus|advcl|START_ENTITY Locus|nsubj|Regulation Regulation|nmod|Genomic Genomic|compound|END_ENTITY	Regulation of the Th1 Genomic Locus from Ifng through Tmevpg1 by T-bet .
22851706	0	Ifng	90,94	Tmevpg1	27,34	Ifng	Tmevpg1	15978(Tax:10090)	103214(Tax:10090)	Gene	Gene	expression|acl|START_ENTITY END_ENTITY|nmod|expression	Cutting edge : influence of Tmevpg1 , a long intergenic noncoding RNA , on the expression of Ifng by Th1 cells .
22685315	0	Ifng	17,21	Twist1	0,6	Ifng	Twist1	3458	7291	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function .
25828538	0	Ift88	17,22	TGF-b	0,5	Ift88	TGF-b	8100	7040	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells .
7525081	0	Ig	25,27	CD5	42,45	Ig	CD5	17329(Tax:10090)	12507(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Signals through membrane Ig of peritoneal CD5 B cells to suppress LPS-induced Ig secretion .
7525081	0	Ig	78,80	CD5	42,45	Ig	CD5	17329(Tax:10090)	12507(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY suppress|dobj|secretion Signals|acl|suppress Signals|nmod|Ig Ig|nmod|cells cells|compound|END_ENTITY	Signals through membrane Ig of peritoneal CD5 B cells to suppress LPS-induced Ig secretion .
14500810	0	Ig-alpha	78,86	Pax-5	109,114	Ig-alpha	Pax-5	973	5079	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Requirements for selective recruitment of Ets proteins and activation of mb-1 / Ig-alpha gene transcription by Pax-5 -LRB- BSAP -RRB- .
10753858	0	Ig-beta	14,21	CD79b	23,28	Ig-beta	CD79b	974	974	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Ig-beta -LRB- CD79b -RRB- by chronic_lymphocytic_leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion .
10839814	0	IgA	70,73	CD89	18,22	IgA	CD89	12518(Tax:10090)	2204	Gene	Gene	nephropathy|appos|START_ENTITY development|nmod|nephropathy mediates|dobj|development mediates|nsubj|receptor receptor|appos|END_ENTITY	Fcalpha receptor -LRB- CD89 -RRB- mediates the development of immunoglobulin_A -LRB- IgA -RRB- nephropathy -LRB- Berger 's _ disease -RRB- .
15371488	0	IgA	40,43	CD89	55,59	IgA	CD89	973	2204	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|appos|END_ENTITY	Differential expression and function of IgA receptors -LRB- CD89 and CD71 -RRB- during maturation of dendritic cells .
23201915	0	IgA	30,33	CD89	47,51	IgA	CD89	973	2204	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Anti-inflammatory role of the IgA Fc receptor -LRB- CD89 -RRB- : from autoimmunity to therapeutic perspectives .
9870466	0	IgA	100,103	CD89	117,121	IgA	CD89	973	2204	Gene	Gene	Fc-receptor|compound|START_ENTITY nephropathy|nmod|Fc-receptor binding|amod|nephropathy binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9870466	0	IgA	37,40	CD89	117,121	IgA	CD89	973	2204	Gene	Gene	binding|appos|START_ENTITY binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9870466	0	IgA	69,72	CD89	117,121	IgA	CD89	973	2204	Gene	Gene	patients|nmod|START_ENTITY binding|nmod|patients binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9741339	0	IgA	11,14	IL-5	50,54	IgA	IL-5	12518(Tax:10090)	16191(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY dependent|nsubj|cells dependent|advmod|END_ENTITY	Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent .
9870466	0	IgA	100,103	IgA	37,40	IgA	IgA	973	973	Gene	Gene	Fc-receptor|compound|START_ENTITY nephropathy|nmod|Fc-receptor binding|amod|nephropathy binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9870466	0	IgA	37,40	IgA	100,103	IgA	IgA	973	973	Gene	Gene	binding|appos|START_ENTITY binding|amod|nephropathy nephropathy|nmod|Fc-receptor Fc-receptor|compound|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9870466	0	IgA	37,40	IgA	69,72	IgA	IgA	973	973	Gene	Gene	binding|appos|START_ENTITY binding|nmod|patients patients|nmod|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
9870466	0	IgA	69,72	IgA	37,40	IgA	IgA	973	973	Gene	Gene	patients|nmod|START_ENTITY binding|nmod|patients binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
12354881	0	IgA	63,66	immunoglobulin_A	45,61	IgA	immunoglobulin A	973	973	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Serodiagnosis of tuberculosis : comparison of immunoglobulin_A -LRB- IgA -RRB- response to sulfolipid_I with IgG and IgM responses to 2,3-diacyltrehalose , 2,3,6-triacyltrehalose , and cord factor antigens .
1921736	0	IgA	26,29	immunoglobulin_A	8,24	IgA	immunoglobulin A	973	973	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Vaginal immunoglobulin_A -LRB- IgA -RRB- levels in post-menopausal women : influence of oestriol therapy .
9870466	0	IgA	37,40	immunoglobulin_A	19,35	IgA	immunoglobulin A	973	973	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
8160012	0	IgA	37,40	interleukin-6	12,25	IgA	interleukin-6	973	3569	Gene	Gene	responses|compound|START_ENTITY role|nmod|responses role|nmod|END_ENTITY	The role of interleukin-6 in mucosal IgA antibody responses in vivo .
12538733	0	IgA1	42,46	CD71	127,131	IgA1	CD71	3493	7037	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|dep|association association|nmod|expression expression|compound|END_ENTITY	Enhanced expression of the CD71 mesangial IgA1 receptor in Berger_disease and Henoch-Sch nlein nephritis : association between CD71 expression and IgA deposits .
12538733	0	IgA1	42,46	CD71	27,31	IgA1	CD71	3493	7037	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Enhanced expression of the CD71 mesangial IgA1 receptor in Berger_disease and Henoch-Sch nlein nephritis : association between CD71 expression and IgA deposits .
24462875	0	IgA1	105,109	CagA	0,4	IgA1	CagA	3493	6279	Gene	Gene	production|nmod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	CagA , a major virulence factor of Helicobacter_pylori , promotes the production and underglycosylation of IgA1 in DAKIKI cells .
10514392	0	IgA1	42,46	IgA1	54,58	IgA1	IgA1	3493	3493	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Increased mucosal production of monomeric IgA1 but no IgA1 protease activity in Helicobacter_pylori_gastritis .
10514392	0	IgA1	54,58	IgA1	42,46	IgA1	IgA1	3493	3493	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Increased mucosal production of monomeric IgA1 but no IgA1 protease activity in Helicobacter_pylori_gastritis .
19178875	0	IgA1	6,10	IgA_nephropathy	30,45	IgA1	IgA nephropathy	3493	60498	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Serum IgA1 from patients with IgA_nephropathy up-regulates integrin-linked_kinase synthesis and inhibits adhesive capacity in podocytes through indirect pathways .
17495453	0	IgA1	45,49	Transferrin_receptor	0,20	IgA1	Transferrin receptor	3493	7037	Gene	Gene	engagement|nmod|START_ENTITY engagement|amod|END_ENTITY	Transferrin_receptor engagement by polymeric IgA1 induces receptor expression and mesangial cell proliferation : role in IgA nephropathy .
12704129	0	IgA1	41,45	immunoglobulin_A1	22,39	IgA1	immunoglobulin A1	3493	3493	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Cleavage of the human immunoglobulin_A1 -LRB- IgA1 -RRB- hinge region by IgA1 proteases requires structures in the Fc region of IgA .
25510296	0	IgAN	54,58	CD147	0,5	IgAN	CD147	60498	682	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	CD147 renal expression as a biomarker for progressive IgAN .
18202089	0	IgA_nephropathy	68,83	Cosmc	54,59	IgA nephropathy	Cosmc	60498	29071	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	External suppression causes the low expression of the Cosmc gene in IgA_nephropathy .
22332537	0	IgA_nephropathy	98,113	Cosmc	57,62	IgA nephropathy	Cosmc	60498	29071	Gene	Gene	patients|compound|START_ENTITY lymphocyte|nmod|patients gene|nmod|lymphocyte gene|amod|END_ENTITY	-LSB- Effect of methylation modification on the expression of Cosmc gene in peripheral B lymphocyte of IgA_nephropathy patients -RSB- .
23136028	0	IgA_nephropathy	97,112	Cosmc	77,82	IgA nephropathy	Cosmc	60498	29071	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Mycophenolic_acid reverses IgA1 aberrant glycosylation through up-regulating Cosmc expression in IgA_nephropathy .
10354275	0	IgA_nephropathy	74,89	GroEL	50,55	IgA nephropathy	GroEL	60498	3329	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Small bowel T cells , HLA class II antigen DR , and GroEL stress protein in IgA_nephropathy .
12566693	0	IgA_nephropathy	77,92	ICAM-1	39,45	IgA nephropathy	ICAM-1	60498	3383	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Tubular and interstitial expression of ICAM-1 as a marker of renal_injury in IgA_nephropathy .
19178875	0	IgA_nephropathy	30,45	IgA1	6,10	IgA nephropathy	IgA1	60498	3493	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Serum IgA1 from patients with IgA_nephropathy up-regulates integrin-linked_kinase synthesis and inhibits adhesive capacity in podocytes through indirect pathways .
12874461	0	IgA_nephropathy	44,59	Protease-activated_receptor-2	0,29	IgA nephropathy	Protease-activated receptor-2	60498	2150	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Protease-activated_receptor-2 expression in IgA_nephropathy : a potential role in the pathogenesis of interstitial_fibrosis .
16517231	0	IgBP1	54,59	alpha4	38,44	IgBP1	alpha4	3476	3476	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Low resolution structure of the human alpha4 protein -LRB- IgBP1 -RRB- and studies on the stability of alpha4 and of its yeast ortholog Tap42 .
25057009	0	IgD	17,20	Zfp318	0,6	IgD	Zfp318	3495	24149	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus .
16172256	0	IgE	54,57	CD23	23,27	IgE	CD23	3497	2208	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure of human CD23 and its interactions with IgE and CD21 .
22802656	0	IgE	21,24	CD23	54,58	IgE	CD23	3497	2208	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc __ RI .
16942574	0	IgE	46,49	FcepsilonRIalpha	51,67	IgE	FcepsilonRIalpha	3497	2205	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The alpha-chain of high-affinity receptor for IgE -LRB- FcepsilonRIalpha -RRB- gene polymorphisms and serum IgE levels .
9398286	0	IgE	42,45	FcepsilonRIalpha	68,84	IgE	FcepsilonRIalpha	3497	2205	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Identification of contact residues in the IgE binding site of human FcepsilonRIalpha .
22578203	0	IgE	42,45	STAT6	17,22	IgE	STAT6	3497	6778	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Polymorphisms of STAT6 and specific serum IgE levels in patients with penicillin allergy .
24055037	0	IgE	28,31	Syntaxin-4	0,10	IgE	Syntaxin-4	3497	6810	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Syntaxin-4 is essential for IgE secretion by plasma cells .
10413189	0	IgE	27,30	immunoglobulin_E	9,25	IgE	immunoglobulin E	3497	3497	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Elevated immunoglobulin_E -LRB- IgE -RRB- levels in children with exposure to environmental lead .
15807855	0	IgE	72,75	immunoglobulin_E	54,70	IgE	immunoglobulin E	3497	3497	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Different natural_killer _ -LRB- NK -RRB- _ receptor expression and immunoglobulin_E -LRB- IgE -RRB- regulation by NK1 and NK2 cells .
23198022	0	IgE	24,27	immunoglobulin_E	6,22	IgE	immunoglobulin E	3497	3497	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum immunoglobulin_E -LRB- IgE -RRB- levels and dietary intake of Korean infants and young children with atopic_dermatitis .
6846921	0	IgE	27,30	immunoglobulin_E	9,25	IgE	immunoglobulin E	3497	3497	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	Value of immunoglobulin_E -LRB- IgE -RRB- in the private practice of allergy .
923104	0	IgE	28,31	immunoglobulin_E	10,26	IgE	immunoglobulin E	3497	3497	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of immunoglobulin_E -LRB- IgE -RRB- in paired examinations of serum and synovial fluid in rheumatoid_arthritis and reactive synovitis of local origin .
11991851	0	IgE	55,58	immunoglobulin_e	37,53	IgE	immunoglobulin e	3497	3497	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Alcohol-induced alterations in serum immunoglobulin_e -LRB- IgE -RRB- levels in human subjects .
2666067	0	IgE	0,3	insulin	18,25	IgE	insulin	3497	3630	Gene	Gene	START_ENTITY|nmod|peptides peptides|compound|END_ENTITY	IgE antibodies to insulin and related peptides , a result of insulin treatment ?
18362472	0	IgE	20,23	lupin	35,40	IgE	lupin	3497	51251	Gene	Gene	Characterization|nmod|START_ENTITY binding|nsubj|Characterization binding|nmod|END_ENTITY	Characterization of IgE binding to lupin , peanut and almond with sera from lupin-allergic patients .
14616317	0	IgE	43,46	mast_cell_tryptase	14,32	IgE	mast cell tryptase	3497	25823	Gene	Gene	antibodies|compound|START_ENTITY antibodies|compound|END_ENTITY	Screening for mast_cell_tryptase and serum IgE antibodies in 18 patients with anaphylactic shock during general anaesthesia .
20351305	0	IgG	22,25	IL-6	0,4	IgG	IL-6	16059(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production .
19570000	0	IgG1	45,49	CD4	61,64	IgG1	CD4	16017(Tax:10090)	12504(Tax:10090)	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Subcutaneous bioavailability of a PRIMATIZED IgG1 anti-human CD4 monoclonal antibody is dose dependent in transgenic_mice bearing human CD4 .
12734361	0	IgG1	31,35	CD86	53,57	IgG1	CD86	16017(Tax:10090)	12524(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY transcription|nsubj|regulation transcription|nmod|END_ENTITY	Selective regulation of mature IgG1 transcription by CD86 and beta 2-adrenergic receptor stimulation .
17353163	0	IgG1	32,36	IL-27	0,5	IgG1	IL-27	16017(Tax:10090)	246778	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-27 induces the production of IgG1 by human B cells .
810516	0	IgG1	45,49	IgG1	86,90	IgG1	IgG1	105243590	105243590	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	A preparation of Fc fragment of normal mouse IgG1 for production of rabbit anti mouse IgG1 serum .
810516	0	IgG1	86,90	IgG1	45,49	IgG1	IgG1	105243590	105243590	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	A preparation of Fc fragment of normal mouse IgG1 for production of rabbit anti mouse IgG1 serum .
11212944	0	IgG1	40,44	IgG2a	46,51	IgG1	IgG2a	16017(Tax:10090)	668478(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY IL-2|dep|END_ENTITY	Quantitative modeling of suppression of IgG1 , IgG2a , IL-2 , and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress .
6799571	0	IgG1	32,36	IgG3	24,28	IgG1	IgG3	16017(Tax:10090)	380795(Tax:10090)	Gene	Gene	Switch|nmod|START_ENTITY Switch|nmod|END_ENTITY	Switch from NP-specific IgG3 to IgG1 in the mouse hybridoma cell line S24/63/63 .
12593784	1	IgG1	29,33	IgM	35,38	IgG1	IgM	105243590	16019(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|dep|END_ENTITY	IgG1 , IgM -RRB- response in mice infected with trichinella_spiralis treated with L-mimosine .
1902147	0	IgG2a	32,37	IFN-gamma	0,9	IgG2a	IFN-gamma	668478(Tax:10090)	15978(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells : implications for the role of IFN-gamma in class switching .
1902147	0	IgG2a	32,37	IFN-gamma	119,128	IgG2a	IFN-gamma	668478(Tax:10090)	15978(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|dep|implications implications|nmod|role role|nmod|END_ENTITY	IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells : implications for the role of IFN-gamma in class switching .
3127461	0	IgG2a	21,26	IFN-gamma	0,9	IgG2a	IFN-gamma	668478(Tax:10090)	15978(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide .
11212944	0	IgG2a	46,51	IgG1	40,44	IgG2a	IgG1	668478(Tax:10090)	16017(Tax:10090)	Gene	Gene	IL-2|dep|START_ENTITY IL-2|compound|END_ENTITY	Quantitative modeling of suppression of IgG1 , IgG2a , IL-2 , and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress .
18184825	0	IgG2a	150,155	immunoglobulin_G1	125,142	IgG2a	immunoglobulin G1	668478(Tax:10090)	16017(Tax:10090)	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|dep|ratio	Optimized immune response elicited by a DNA vaccine expressing pneumococcal_surface_protein_a is characterized by a balanced immunoglobulin_G1 -LRB- IgG1 -RRB- / IgG2a ratio and proinflammatory cytokine production .
8225387	0	IgG2b	28,33	c-fos	12,17	IgG2b	c-fos	16016(Tax:10090)	14281(Tax:10090)	Gene	Gene	production|amod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Deregulated c-fos modulates IgG2b production of B cells mediated by lipopolysaccharide .
6799571	0	IgG3	24,28	IgG1	32,36	IgG3	IgG1	380795(Tax:10090)	16017(Tax:10090)	Gene	Gene	Switch|nmod|START_ENTITY Switch|nmod|END_ENTITY	Switch from NP-specific IgG3 to IgG1 in the mouse hybridoma cell line S24/63/63 .
1373759	0	IgG3	13,17	interferon_gamma	31,47	IgG3	interferon gamma	380795(Tax:10090)	15978(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Induction of IgG3 secretion by interferon_gamma : a model for T cell-independent class switching in response to T cell-independent type 2 antigens .
12208673	0	IgG_Fc_binding_protein	27,49	FcgammaBP	51,60	IgG Fc binding protein	FcgammaBP	8857	8857	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of IgG_Fc_binding_protein -LRB- FcgammaBP -RRB- in human normal thyroid tissue , thyroid adenomas and thyroid_carcinomas .
10555759	0	IgH	19,22	BCL-2	13,18	IgH	BCL-2	3492	596	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Evolution of BCL-2 / IgH hybrid gene RNA expression during treatment of T -LRB- 14 ; 18 -RRB- - bearing follicular_lymphomas .
10828038	0	IgH	28,31	BCL-2	22,27	IgH	BCL-2	3492	596	Gene	Gene	junctions|compound|START_ENTITY junctions|compound|END_ENTITY	Follicular_lymphomas ' BCL-2 / IgH junctions contain templated nucleotide insertions : novel insights into the mechanism of t -LRB- 14 ; 18 -RRB- translocation .
11920254	0	IgH	43,46	BCL-2	3,8	IgH	BCL-2	3492	596	Gene	Gene	rearrangements|compound|START_ENTITY protein|dep|rearrangements protein|compound|END_ENTITY	No BCL-2 protein over expression but BCL-2 / IgH rearrangements in B cells of patients with persistent polyclonal B-cell_lymphocytosis .
11920254	0	IgH	43,46	BCL-2	37,42	IgH	BCL-2	3492	596	Gene	Gene	rearrangements|compound|START_ENTITY protein|dep|rearrangements protein|nmod|END_ENTITY	No BCL-2 protein over expression but BCL-2 / IgH rearrangements in B cells of patients with persistent polyclonal B-cell_lymphocytosis .
16215945	0	IgH	7,10	BCL-2	1,6	IgH	BCL-2	3492	596	Gene	Gene	translocation|nsubj|START_ENTITY END_ENTITY|parataxis|translocation	-LSB- BCL-2 / IgH translocation in peripheral blood cells of healthy Chinese individuals of Han nationality located in Zhejiang area -RSB- .
20368567	0	IgH	6,9	BCL-2	0,5	IgH	BCL-2	3492	596	Gene	Gene	status|amod|START_ENTITY predictive|nsubj|status END_ENTITY|appos|predictive	BCL-2 / IgH polymerase chain reaction status at the end of induction treatment is not predictive for progression-free survival in relapsed/resistant follicular_lymphoma : results of a prospective randomized EORTC 20981 phase III intergroup study .
21518492	0	IgH	7,10	BCL-2	1,6	IgH	BCL-2	3492	596	Gene	Gene	rearrangements|compound|START_ENTITY rearrangements|dep|END_ENTITY	-LSB- BCL-2 / IgH and IgH gene rearrangements in bone marrow mononuclear cells of patients with non-Hodgkin 's _ lymphoma -RSB- .
11208834	0	IgH	23,26	Bcl-2	17,22	IgH	Bcl-2	3492	596	Gene	Gene	rearrangement|compound|START_ENTITY rearrangement|nmod|END_ENTITY	Frequency of the Bcl-2 / IgH rearrangement in normal individuals : implications for the monitoring of disease in patients with follicular_lymphoma .
12139744	0	IgH	74,77	Bcl-2	68,73	IgH	Bcl-2	3492	596	Gene	Gene	rearrangements|nsubj|START_ENTITY assay|parataxis|rearrangements assay|nmod|END_ENTITY	JH probe real-time quantitative polymerase chain reaction assay for Bcl-2 / IgH rearrangements .
12663733	0	IgH	35,38	Bcl-2	29,34	IgH	Bcl-2	3492	596	Gene	Gene	rearrangements|compound|START_ENTITY common|nsubj|rearrangements END_ENTITY|parataxis|common	PCR-detectable nonneoplastic Bcl-2 / IgH rearrangements are common in normal subjects and cancer patients at diagnosis but rare in subjects treated with chemotherapy .
12962724	0	IgH	20,23	Bcl-2	14,19	IgH	Bcl-2	3492	596	Gene	Gene	reaction|compound|START_ENTITY reaction|compound|END_ENTITY	Recurrence of Bcl-2 / IgH polymerase chain reaction positivity following a prolonged molecular remission can be unrelated to the original follicular_lymphoma clone .
18072430	0	IgH	17,20	Bcl-2	11,16	IgH	Bcl-2	3492	596	Gene	Gene	negativity|compound|START_ENTITY implies|nsubj|negativity END_ENTITY|parataxis|implies	-LSB- Achieving Bcl-2 / IgH negativity in peripheral blood/bone marrow after therapy implies better prognosis for patients with follicular_lymphoma -RSB- .
18636259	0	IgH	103,106	Bcl-2	97,102	IgH	Bcl-2	3492	596	Gene	Gene	rearrangement|nsubj|START_ENTITY PCR|parataxis|rearrangement PCR|acl|PCR PCR|nmod|monitoring monitoring|nmod|END_ENTITY	Commercial LightCycler-based quantitative real-time PCR compared to nested PCR for monitoring of Bcl-2 / IgH rearrangement in patients with follicular_lymphoma .
18665753	0	IgH	63,66	Bcl-2	57,62	IgH	Bcl-2	3492	596	Gene	Gene	rearrangement|compound|START_ENTITY characteristics|dep|rearrangement characteristics|nmod|END_ENTITY	Molecular characteristics and prognostic significance of Bcl-2 / IgH gene rearrangement in Serbian follicular_lymphoma patients .
1902122	0	IgH	24,27	Bcl-2	65,70	IgH	Bcl-2	3492	596	Gene	Gene	gene|compound|START_ENTITY organization|nmod|gene organization|nmod|gene gene|compound|END_ENTITY	Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t -LRB- 14 ; 18 -RRB- - positive lymphoma .
19858392	0	IgH	36,39	Bcl-2	30,35	IgH	Bcl-2	3492	596	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Quantitative PCR analysis for Bcl-2 / IgH in a phase III study of Yttrium-90 Ibritumomab Tiuxetan as consolidation of first remission in patients with follicular_lymphoma .
21309729	0	IgH	24,27	Bcl-2	18,23	IgH	Bcl-2	3492	596	Gene	Gene	sequences|compound|START_ENTITY using|nsubj|sequences Identification|parataxis|using Identification|nmod|END_ENTITY	Identification of Bcl-2 / IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis .
22052344	0	IgH	6,9	Bcl-2	0,5	IgH	Bcl-2	3492	596	Gene	Gene	expression|compound|START_ENTITY infiltration|nsubj|expression END_ENTITY|parataxis|infiltration	Bcl-2 / IgH expression in minimal bone marrow infiltration by follicular_lymphoma cells .
26239087	0	IgH	38,41	Bcl-2	32,37	IgH	Bcl-2	3492	596	Gene	Gene	levels|compound|START_ENTITY levels|dep|Prognostic Prognostic|dobj|value value|acl|circulating circulating|dobj|END_ENTITY	Prognostic value of circulating Bcl-2 / IgH levels in patients with follicular_lymphoma receiving first-line immunochemotherapy .
12153169	0	IgH	6,9	Bcl-3	0,5	IgH	Bcl-3	3492	602	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Bcl-3 / IgH translocation -LRB- 14 ; 19 -RRB- -LRB- q32 ; q13 -RRB- in non-Hodgkin 's _ lymphomas .
14514791	0	IgH	37,40	CCND1	17,22	IgH	CCND1	3495	595	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Insertion of the CCND1 gene into the IgH locus in a case of leukaemic small cell mantle_lymphoma with normal chromosomes 11 and 14 .
15101720	0	IgH	59,62	bcl-2	53,58	IgH	bcl-2	3492	596	Gene	Gene	rearrangement|compound|START_ENTITY Correlation|dep|rearrangement Correlation|nmod|END_ENTITY	Correlation between histological subtype and type of bcl-2 / IgH rearrangement in follicular_lymphomas .
15875184	0	IgH	82,85	bcl-2	76,81	IgH	bcl-2	3492	596	Gene	Gene	translocation|compound|START_ENTITY translocation|amod|END_ENTITY	Molecular epidemiology of follicular_lymphoma in Chinese : relationship with bcl-2 / IgH translocation and bcl-6 397G/C polymorphism .
15990705	0	IgH	19,22	bcl-2	13,18	IgH	bcl-2	3492	596	Gene	Gene	START_ENTITY|dep|Frequency Frequency|dep|END_ENTITY	Frequency of bcl-2 / IgH translocation in patients with non-Hodgkin 's _ lymphoma and chronic_hepatitis_C_virus_infection .
16297448	0	IgH	10,13	bcl-2	4,9	IgH	bcl-2	3492	596	Gene	Gene	rearrangement|compound|START_ENTITY rearrangement|amod|END_ENTITY	The bcl-2 / IgH rearrangement in a population of 204 healthy individuals : occurrence , age and gender distribution , breakpoints , and detection method validity .
16530831	0	IgH	175,178	bcl-2	169,174	IgH	bcl-2	3492	596	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	One single dose of rituximab added to a standard regimen of CHOP in primary treatment of follicular_lymphoma appears to result in a high clearance rate from circulating bcl-2 / IgH positive cells : Is the end of molecular monitoring near ?
16532966	0	IgH	20,23	bcl-2	14,19	IgH	bcl-2	3492	596	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	-LSB- Detection of bcl-2 / IgH gene rearrangement in diffuse_large_B_cell_lymphoma by hemi-nested PCR -RSB- .
17157165	0	IgH	44,47	bcl-2	38,43	IgH	bcl-2	3492	596	Gene	Gene	rearrangements|compound|START_ENTITY rearrangements|amod|END_ENTITY	Cells carrying nonlymphoma-associated bcl-2 / IgH rearrangements -LRB- NLABR -RRB- are phenotypically related to follicular_lymphoma and can establish as long-term persisting clonal populations .
17408460	0	IgH	48,51	bcl-2	42,47	IgH	bcl-2	3492	596	Gene	Gene	+|nsubj|START_ENTITY follicular_lymphoma|parataxis|+ follicular_lymphoma|dep|spread spread|nmod|END_ENTITY	Stage I/II follicular_lymphoma : spread of bcl-2 / IgH + cells in blood and bone marrow from primary site of disease and possibility of clearance after involved field radiotherapy .
18695675	0	IgH	42,45	bcl-2	68,73	IgH	bcl-2	3492	596	Gene	Gene	cells|nmod:poss|START_ENTITY cells|amod|enhancers enhancers|nmod|region region|amod|END_ENTITY	Functional long-range interactions of the IgH 3 ' enhancers with the bcl-2 promoter region in t -LRB- 14 ; 18 -RRB- lymphoma cells .
19379568	0	IgH	20,23	bcl-2	14,19	IgH	bcl-2	3492	596	Gene	Gene	gene|compound|START_ENTITY Detection|dep|gene Detection|nmod|END_ENTITY	-LSB- Detection of bcl-2 / IgH fusion gene in lymphoma by real-time polymerase chain reaction and its clinical significance -RSB- .
20426554	0	IgH	49,52	bcl-2	43,48	IgH	bcl-2	3492	596	Gene	Gene	non-Hodgkin|compound|START_ENTITY non-Hodgkin|amod|END_ENTITY	A rapid two-step method for elimination of bcl-2 / IgH positive non-Hodgkin 's _ lymphoma cells from human blood or marrow stem cells , employing immunomagnetic purging with streptavidin-coated_ferrofluids .
21103627	0	IgH	52,55	bcl-2	46,51	IgH	bcl-2	3492	596	Gene	Gene	translocation|compound|START_ENTITY translocation|amod|END_ENTITY	Prognostic and predictive significance of the bcl-2 / IgH translocation in malignant follicular_lymphomas .
8417783	0	IgH	52,55	bcl-2	46,51	IgH	bcl-2	3492	596	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|expression expression|nmod|END_ENTITY	Analysis of the expression of the hybrid gene bcl-2 / IgH in follicular_lymphomas .
8700536	0	IgH	8,11	bcl-2	2,7	IgH	bcl-2	3492	596	Gene	Gene	transcript|compound|START_ENTITY transcript|amod|END_ENTITY	A bcl-2 / IgH antisense transcript deregulates bcl-2 gene expression in human follicular_lymphoma t -LRB- 14 ; 18 -RRB- cell lines .
8700536	0	IgH	8,11	bcl-2	45,50	IgH	bcl-2	3492	596	Gene	Gene	transcript|compound|START_ENTITY deregulates|nsubj|transcript deregulates|xcomp|lines lines|nsubj|expression expression|amod|END_ENTITY	A bcl-2 / IgH antisense transcript deregulates bcl-2 gene expression in human follicular_lymphoma t -LRB- 14 ; 18 -RRB- cell lines .
9592988	0	IgH	58,61	bcl-2	52,57	IgH	bcl-2	3492	596	Gene	Gene	rearrangements|compound|START_ENTITY B_lymphocytosis|dep|rearrangements B_lymphocytosis|nmod|END_ENTITY	Persistent polyclonal B_lymphocytosis with multiple bcl-2 / IgH rearrangements : a benign disorder .
9592350	0	IgH	42,45	immunoglobulin_heavy_chain	14,40	IgH	immunoglobulin heavy chain	3495	3495	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Detection of immunoglobulin_heavy_chain -LRB- IgH -RRB- gene rearrangement in ANLL by polymerase chain reaction amplification and Southern blot -RSB- .
12593784	1	IgM	35,38	IgG1	29,33	IgM	IgG1	16019(Tax:10090)	105243590	Gene	Gene	response|dep|START_ENTITY response|compound|END_ENTITY	IgG1 , IgM -RRB- response in mice infected with trichinella_spiralis treated with L-mimosine .
9381890	0	Ig_E	24,28	immunoglobulin_E	6,22	Ig E	immunoglobulin E	3497	3497	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Serum immunoglobulin_E -LRB- Ig_E -RRB- levels after myocardial_infarction .
15040449	0	Ig_beta	42,49	B29	37,40	Ig beta	B29	974	974	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A conserved sequence upstream of the B29 -LRB- Ig_beta , CD79b -RRB- gene interacts with YY1 .
12459553	0	Igbeta	40,46	Phosphoinositide_3-kinase	0,25	Igbeta	Phosphoinositide 3-kinase	974	5293	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Phosphoinositide_3-kinase activation by Igbeta controls de novo formation of an antigen-processing compartment .
25790853	0	Igf1	14,18	Ezh2	33,37	Igf1	Ezh2	16000(Tax:10090)	14056(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung .
10942631	0	Igf1	28,32	GLUT1	8,13	Igf1	GLUT1	16000(Tax:10090)	20512(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduced GLUT1 expression in Igf1 - / - null oocytes and follicles .
15060168	0	Igf2	96,100	CTCF	21,25	Igf2	CTCF	3481	10664	Gene	Gene	patterns|amod|START_ENTITY loss|nmod|patterns leads|nmod|loss leads|nsubj|Mutation Mutation|nmod|site site|compound|END_ENTITY	Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance .
16815976	0	Igf2	147,151	CTCF	0,4	Igf2	CTCF	3481	10664	Gene	Gene	restrict|nmod|START_ENTITY inherited|advcl|restrict inherited|nsubj|mediates mediates|nummod|END_ENTITY	CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2 .
18662993	0	Igf2	37,41	CTCF	0,4	Igf2	CTCF	16002(Tax:10090)	13018(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb_repressive_complex_2_intrachromosomal_loop .
22514330	0	Igf2	69,73	insulin-like_growth_factor_2	39,67	Igf2	insulin-like growth factor 2	16002(Tax:10090)	16002(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	IkB kinase/nuclear factor kB-dependent insulin-like_growth_factor_2 -LRB- Igf2 -RRB- expression regulates synapse formation and spine maturation via Igf2 receptor signaling .
7720562	0	Igf2r	157,162	insulin-like_growth_factor_2_receptor	118,155	Igf2r	insulin-like growth factor 2 receptor	16004(Tax:10090)	16004(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mouse embryonic germ -LRB- EG -RRB- cell lines : transmission through the germline and differences in the methylation imprint of insulin-like_growth_factor_2_receptor -LRB- Igf2r -RRB- gene compared with embryonic stem -LRB- ES -RRB- cell lines .
19332648	0	Igfbp5	73,79	insulin-like_growth_factor_binding_protein-5	27,71	Igfbp5	insulin-like growth factor binding protein-5	16011(Tax:10090)	16011(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	IGF-independent effects of insulin-like_growth_factor_binding_protein-5 -LRB- Igfbp5 -RRB- in vivo .
3920661	0	Igh	58,61	immunoglobulin_heavy_chain_locus	63,95	Igh	immunoglobulin heavy chain locus	111507(Tax:10090)	111507(Tax:10090)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Suppressor T-cell factor -LRB- s -RRB- display an altered pattern of Igh -LRB- immunoglobulin_heavy_chain_locus -RRB- genetic restriction when developed in an Igh-congeneic host .
8100806	0	Igk	65,68	transforming_growth_factor_alpha	22,54	Igk	transforming growth factor alpha	243469(Tax:10090)	21802(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Linkage of the murine transforming_growth_factor_alpha gene with Igk , Ly-2 , and Fabp1 on chromosome 6 .
16141219	0	Ihh	0,3	Gli3	51,55	Ihh	Gli3	16147(Tax:10090)	14634(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Ihh controls cartilage development by antagonizing Gli3 , but requires additional effectors to regulate osteoblast and vascular development .
21044292	0	Ihog	0,4	Hedgehog	31,39	Ihog	Hedgehog	33972(Tax:7227)	42737(Tax:7227)	Gene	Gene	essential|nsubj|START_ENTITY essential|advcl|END_ENTITY	Ihog and Boi are essential for Hedgehog signaling in Drosophila .
23154411	0	Ihog	131,135	Hedgehog	67,75	Ihog	Hedgehog	33972(Tax:7227)	42737(Tax:7227)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi .
25777566	0	Ik-1	26,30	IGF-IR	53,59	Ik-1	IGF-IR	10320	3480	Gene	Gene	downregulate|nsubj|START_ENTITY downregulate|dobj|expression expression|compound|END_ENTITY	The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK -LRB- + -RRB- T-cell_lymphoma .
25884514	0	Ik-1	26,30	IGF-IR	53,59	Ik-1	IGF-IR	10320	3480	Gene	Gene	downregulate|nsubj|START_ENTITY downregulate|dobj|expression expression|compound|END_ENTITY	The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALK -LRB- + -RRB- T-cell_lymphoma .
23613522	0	IkB	0,3	SNAP-23	30,37	IkB	SNAP-23	18036(Tax:10090)	20619(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	IkB kinase phosphorylation of SNAP-23 controls platelet secretion .
22988300	0	IkB_kinase_2	0,12	TPL-2	23,28	IkB kinase 2	TPL-2	3551	1326	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	IkB_kinase_2 regulates TPL-2 activation of extracellular_signal-regulated_kinases_1_and_2 by direct phosphorylation of TPL-2 serine 400 .
22988300	0	IkB_kinase_2	0,12	extracellular_signal-regulated_kinases_1_and_2	43,89	IkB kinase 2	extracellular signal-regulated kinases 1 and 2	3551	5595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	IkB_kinase_2 regulates TPL-2 activation of extracellular_signal-regulated_kinases_1_and_2 by direct phosphorylation of TPL-2 serine 400 .
25881508	0	IkBa	20,24	GRK6	0,4	IkBa	GRK6	4792	2870	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	GRK6 phosphorylates IkBa at Ser -LRB- 32 -RRB- / Ser -LRB- 36 -RRB- and enhances TNF-a-induced inflammation .
24457201	0	IkBa	56,60	Ribosomal_protein_S3	0,20	IkBa	Ribosomal protein S3	4792	6188	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ribosomal_protein_S3 interacts with the NF-kB inhibitor IkBa .
9367996	0	IkappaB-alpha	19,32	CPP32	66,71	IkappaB-alpha	CPP32	396093(Tax:9031)	836	Gene	Gene	Phosphorylation|nmod|START_ENTITY inhibits|nsubj|Phosphorylation inhibits|nmod|END_ENTITY	Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro .
12411051	0	IkappaB-alpha	27,40	TNF-alpha	52,61	IkappaB-alpha	TNF-alpha	4792	7124	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Study on the expression of IkappaB-alpha protein in TNF-alpha induced apoptosis of U937 cells .
17644309	0	IkappaB-kinase_alpha	33,53	Protein_kinase_C_delta	0,22	IkappaB-kinase alpha	Protein kinase C delta	1147	5580	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Protein_kinase_C_delta activates IkappaB-kinase_alpha to induce the p53 tumor suppressor in response to oxidative stress .
19595668	0	IkappaB-zeta	16,28	STAT3	54,59	IkappaB-zeta	STAT3	80859(Tax:10090)	20848(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Nuclear protein IkappaB-zeta inhibits the activity of STAT3 .
15749903	0	IkappaBNS	28,37	IL-6	86,90	IkappaBNS	IL-6	243910(Tax:10090)	16193(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic_lamina_propria .
11246458	0	IkappaBR	63,71	NFKBIL2	78,85	IkappaBR	NFKBIL2	4796	4796	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation , sequence , and chromosomal localisation of the human IkappaBR gene -LRB- NFKBIL2 -RRB- .
18688039	0	IkappaB_Kinase-alpha	36,56	RelB	0,4	IkappaB Kinase-alpha	RelB	12675(Tax:10090)	19698(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	RelB is differentially regulated by IkappaB_Kinase-alpha in B cells and mouse lung by cigarette smoke .
11902829	0	IkappaB_kinase	39,53	IKK-i	55,60	IkappaB kinase	IKK-i	9641	9641	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of inducible IkappaB_kinase -LRB- IKK-i -RRB- in human fibroblast-like synoviocytes .
19168710	0	IkappaB_kinase-2	41,57	IKK-2	59,64	IkappaB kinase-2	IKK-2	3551	3551	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	A novel , highly selective , tight binding IkappaB_kinase-2 -LRB- IKK-2 -RRB- inhibitor : a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kappaB pathway in arthritis-relevant cells and animal models .
9346485	0	IkappaB_kinase-alpha	69,89	NF-kappaB	21,30	IkappaB kinase-alpha	NF-kappaB	1147	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	IkappaB_kinase-beta : NF-kappaB activation and complex formation with IkappaB_kinase-alpha and NIK .
20534585	0	IkappaB_kinase-beta	41,60	IKKbeta	62,69	IkappaB kinase-beta	IKKbeta	3551	3551	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Tyrosine phosphorylation is required for IkappaB_kinase-beta -LRB- IKKbeta -RRB- activation and function in osteoclastogenesis .
18704119	0	IkappaB_kinase_2	61,77	JNK	24,27	IkappaB kinase 2	JNK	16150(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB_kinase_2 to prevent endotoxin-induced liver_failure .
10779355	0	IkappaB_kinase_alpha	0,20	IKKbeta	46,53	IkappaB kinase alpha	IKKbeta	1147	3551	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	IkappaB_kinase_alpha -LRB- IKKalpha -RRB- regulation of IKKbeta kinase activity .
10593965	0	IkappaB_kinase_alpha	29,49	IkappaBalpha	69,81	IkappaB kinase alpha	IkappaBalpha	12675(Tax:10090)	18035(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Aminosalicylic_acid inhibits IkappaB_kinase_alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells .
15155743	0	IkappaB_kinase_alpha	0,20	IkappaBalpha	125,137	IkappaB kinase alpha	IkappaBalpha	1147	4792	Gene	Gene	contribute|nsubj|START_ENTITY contribute|xcomp|optimal optimal|dobj|expression expression|nmod|degradation degradation|compound|END_ENTITY	IkappaB_kinase_alpha and p65/RelA contribute to optimal epidermal_growth_factor-induced c-fos gene expression independent of IkappaBalpha degradation .
9689078	0	IkappaB_kinase_alpha	21,41	MEKK1	0,5	IkappaB kinase alpha	MEKK1	1147	4214	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	MEKK1 activates both IkappaB_kinase_alpha and IkappaB_kinase_beta .
17897950	0	IkappaB_kinase_alpha	46,66	USP11	28,33	IkappaB kinase alpha	USP11	1147	8237	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	The deubiquitinating enzyme USP11 controls an IkappaB_kinase_alpha -LRB- IKKalpha -RRB- - p53 signaling pathway in response to tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- .
17709380	0	IkappaB_kinase_beta	0,19	A20	58,61	IkappaB kinase beta	A20	3551	28935	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	IkappaB_kinase_beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway .
16230390	0	IkappaB_kinase_beta	28,47	Cyclin_D1	0,9	IkappaB kinase beta	Cyclin D1	16150(Tax:10090)	595	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cyclin_D1 induction through IkappaB_kinase_beta / nuclear_factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes .
15574499	0	IkappaB_kinase_beta	0,19	IL-1	68,72	IkappaB kinase beta	IL-1	3551	3553	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|nmod|END_ENTITY	IkappaB_kinase_beta phosphorylates Dok1 serines in response to TNF , IL-1 , or gamma radiation .
17259348	0	IkappaB_kinase_epsilon	14,36	androgen_receptor	55,72	IkappaB kinase epsilon	androgen receptor	9641	367	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of IkappaB_kinase_epsilon expression by the androgen_receptor and the nuclear factor-kappaB transcription factor in prostate_cancer .
17003035	0	IkappaB_kinase_epsilon	0,22	p52	38,41	IkappaB kinase epsilon	p52	9641	4791	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	IkappaB_kinase_epsilon interacts with p52 and promotes transactivation via p65 .
15212763	0	IkappaB_kinase_gamma	88,108	NF-kappaB	36,45	IkappaB kinase gamma	NF-kappaB	16151(Tax:10090)	18033(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	NF-kappaB inducing kinase activates NF-kappaB transcriptional activity independently of IkappaB_kinase_gamma through a p38_MAPK-dependent RelA phosphorylation pathway .
18245554	0	IkappaB_kinase_subunit_2	14,38	nuclear_factor-kappaB	83,104	IkappaB kinase subunit 2	nuclear factor-kappaB	3551	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Inhibition of IkappaB_kinase_subunit_2 in cutaneous_T-cell_lymphoma down-regulates nuclear_factor-kappaB constitutive activation , induces cell death , and potentiates the apoptotic response to antineoplastic chemotherapeutic agents .
17565996	0	IkappaBalpha	111,123	Bcl-2	72,77	IkappaBalpha	Bcl-2	4792	596	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha .
12748192	0	IkappaBalpha	107,119	CKII	74,78	IkappaBalpha	CKII	4792	1457	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2 / Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1 .
11106428	0	IkappaBalpha	18,30	Fas-associated_phosphatase-1	49,77	IkappaBalpha	Fas-associated phosphatase-1	4792	5783	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|substrate substrate|nmod|END_ENTITY	Identification of IkappaBalpha as a substrate of Fas-associated_phosphatase-1 .
20515776	0	IkappaBalpha	0,12	Hes1	23,27	IkappaBalpha	Hes1	18035(Tax:10090)	15205(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	IkappaBalpha regulates Hes1 in osteoclast differentiation and resorption .
10644755	0	IkappaBalpha	64,76	Homodimer	0,9	IkappaBalpha	Homodimer	4792	6647	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination .
10593965	0	IkappaBalpha	69,81	IkappaB_kinase_alpha	29,49	IkappaBalpha	IkappaB kinase alpha	18035(Tax:10090)	12675(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Aminosalicylic_acid inhibits IkappaB_kinase_alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells .
15155743	0	IkappaBalpha	125,137	IkappaB_kinase_alpha	0,20	IkappaBalpha	IkappaB kinase alpha	4792	1147	Gene	Gene	degradation|compound|START_ENTITY expression|nmod|degradation optimal|dobj|expression contribute|xcomp|optimal contribute|nsubj|END_ENTITY	IkappaB_kinase_alpha and p65/RelA contribute to optimal epidermal_growth_factor-induced c-fos gene expression independent of IkappaBalpha degradation .
10340762	0	IkappaBalpha	8,20	NF-kappaB	78,87	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|translocation translocation|nmod|END_ENTITY	Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells .
10383397	1	IkappaBalpha	172,184	NF-kappaB	120,129	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY activity|nmod|degradation transcriptional|dobj|activity transcriptional|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation .
10400699	0	IkappaBalpha	66,78	NF-kappaB	119,128	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	truncation|nmod|START_ENTITY truncation|acl:relcl|functions functions|nmod|inhibitor inhibitor|nmod|END_ENTITY	Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB .
10454561	0	IkappaBalpha	123,135	NF-kappaB	86,95	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	promoter|compound|START_ENTITY regulates|dobj|promoter END_ENTITY|acl:relcl|regulates	Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter .
10962577	0	IkappaBalpha	98,110	NF-kappaB	73,82	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|sensitivity sensitivity|nmod|cells cells|nmod|END_ENTITY	Paclitaxel sensitivity of breast_cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide .
11416149	0	IkappaBalpha	101,113	NF-kappaB	29,38	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	specific|nmod|START_ENTITY requires|xcomp|specific requires|nsubj|activation activation|nmod|END_ENTITY	Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha .
11416157	0	IkappaBalpha	43,55	NF-kappaB	89,98	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY provides|nsubj|association provides|dobj|mechanism mechanism|nmod|END_ENTITY	Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes .
12444159	0	IkappaBalpha	116,128	NF-kappaB	33,42	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	kinase|compound|START_ENTITY suppression|nmod|kinase inhibits|nmod|suppression inhibits|dobj|activation activation|compound|END_ENTITY	Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation .
12663663	0	IkappaBalpha	16,28	NF-kappaB	89,98	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	phosphorylation|compound|START_ENTITY control|nmod|phosphorylation control|dep|loop loop|nmod|complexes complexes|amod|END_ENTITY	RelA control of IkappaBalpha phosphorylation : a positive feedback loop for high affinity NF-kappaB complexes .
12807725	0	IkappaBalpha	111,123	NF-kappaB	68,77	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	kinase|compound|START_ENTITY inhibition|nmod|kinase smoke-induced|nmod|inhibition smoke-induced|dobj|activation activation|amod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
12909638	0	IkappaBalpha	98,110	NF-kappaB	56,65	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Hepatitis_C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease .
14630924	0	IkappaBalpha	120,132	NF-kappaB	22,31	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	kinase|compound|START_ENTITY inhibition|nmod|kinase induced|nmod|inhibition activation|acl|induced activation|amod|END_ENTITY	Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation : abrogation of cyclin_D1 , cyclooxygenase-2 , and matrix metalloprotease-9 .
15372276	0	IkappaBalpha	124,136	NF-kappaB	31,40	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	expression|compound|START_ENTITY increase|nmod|expression keratinocytes|nmod|increase activity|nmod|keratinocytes activity|amod|END_ENTITY	1alpha ,25 -LRB- OH -RRB- -LRB- 2 -RRB- D -LRB- 3 -RRB- regulates NF-kappaB DNA binding activity in cultured normal human keratinocytes through an increase in IkappaBalpha expression .
15731464	0	IkappaBalpha	68,80	NF-kappaB	9,18	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	oscillations|compound|START_ENTITY stress|nmod|oscillations regulation|nmod|stress regulation|amod|END_ENTITY	Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations : real-time analysis of flow-mediated activation in live cells .
15856023	0	IkappaBalpha	99,111	NF-kappaB	15,24	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha , IKK pathway in human prostate_cancer PC-3 cells .
16087206	0	IkappaBalpha	169,181	NF-kappaB	124,133	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	synthesis|compound|START_ENTITY increase|nmod|synthesis involves|nmod|increase involves|dobj|blockade blockade|nmod|activation activation|amod|END_ENTITY	Inhibition of lipopolysaccharide-stimulated NO production by crotafuran_B in RAW 264.7 macrophages involves the blockade of NF-kappaB activation through the increase in IkappaBalpha synthesis .
16207380	0	IkappaBalpha	14,26	NF-kappaB	52,61	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression involves|nsubj|Regulation involves|dep|signaling signaling|nsubj|END_ENTITY	Regulation of IkappaBalpha expression involves both NF-kappaB and the MAP kinase signaling pathways .
16231352	0	IkappaBalpha	110,122	NF-kappaB	89,98	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A high-fat diet impairs liver_regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor , IkappaBalpha .
16407234	0	IkappaBalpha	86,98	NF-kappaB	30,39	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	promoter|compound|START_ENTITY blocking|nmod|promoter disrupts|advcl|blocking disrupts|dobj|regulation regulation|amod|END_ENTITY	Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes .
16626517	0	IkappaBalpha	47,59	NF-kappaB	82,91	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	transfer|nmod|START_ENTITY Effects|nmod|transfer Effects|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of adenoviral gene transfer of mutated IkappaBalpha , a novel inhibitor of NF-kappaB , on human monocyte-derived dendritic cells .
17148610	0	IkappaBalpha	11,23	NF-kappaB	64,73	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	START_ENTITY|acl:relcl|critical critical|nmod|inhibition inhibition|nmod|END_ENTITY	Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB .
17310217	0	IkappaBalpha	0,12	NF-kappaB	38,47	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells .
17318178	0	IkappaBalpha	48,60	NF-kappaB	13,22	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	deubiquitinylation|nmod|START_ENTITY controls|nmod|deubiquitinylation controls|dobj|END_ENTITY	CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha .
17371256	0	IkappaBalpha	35,47	NF-kappaB	15,24	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|Control Control|nmod|END_ENTITY	Control of the NF-kappaB inhibitor IkappaBalpha in pathogen infection .
17441336	0	IkappaBalpha	22,34	NF-kappaB	38,47	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	-LSB- Regulatory effect of IkappaBalpha on NF-kappaB activity during viral gene transactivation in patients with steroid responsive simple nephrotic_syndrome -RSB- .
18224289	0	IkappaBalpha	16,28	NF-kappaB	95,104	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	Modification|nmod|START_ENTITY inhibits|nsubj|Modification inhibits|xcomp|tumor_necrosis_factor tumor_necrosis_factor|dobj|activation activation|amod|END_ENTITY	Modification of IkappaBalpha by taurine_bromamine inhibits tumor_necrosis_factor alpha-induced NF-kappaB activation .
18353872	0	IkappaBalpha	81,93	NF-kappaB	21,30	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY occurs|nmod|phosphorylation occurs|nsubj|activation activation|compound|END_ENTITY	High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells : involvement of Syk tyrosine kinase .
18401342	0	IkappaBalpha	46,58	NF-kappaB	0,9	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	pathway|nmod|START_ENTITY dictates|dobj|pathway dictates|nsubj|END_ENTITY	NF-kappaB dictates the degradation pathway of IkappaBalpha .
18511071	0	IkappaBalpha	12,24	NF-kappaB	43,52	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	alters|nsubj|START_ENTITY alters|dobj|control control|nmod|signaling signaling|compound|END_ENTITY	Pre-folding IkappaBalpha alters control of NF-kappaB signaling .
18606063	0	IkappaBalpha	33,45	NF-kappaB	15,24	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	transfection|compound|START_ENTITY transfection|compound|END_ENTITY	-LSB- Inhibition of NF-kappaB through IkappaBalpha transfection affects invasion of human lung_cancer cell line A549 -RSB- .
18632959	0	IkappaBalpha	63,75	NF-kappaB	81,90	IkappaBalpha	NF-kappaB	406188(Tax:9823)	4790	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The Npro product of classical_swine_fever_virus interacts with IkappaBalpha , the NF-kappaB inhibitor .
19327364	0	IkappaBalpha	130,142	NF-kappaB	105,114	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	binding|nmod|START_ENTITY DNA|amod|binding DNA|compound|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
19327364	0	IkappaBalpha	130,142	NF-kappaB	62,71	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	binding|nmod|START_ENTITY DNA|amod|binding inhibition|nmod|DNA insights|nmod|inhibition Interaction|dep|insights Interaction|nmod|sequence sequence|nmod|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
19327364	0	IkappaBalpha	19,31	NF-kappaB	105,114	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	sequence|compound|START_ENTITY Interaction|nmod|sequence Interaction|dep|insights insights|nmod|inhibition inhibition|nmod|DNA DNA|compound|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
19327364	0	IkappaBalpha	19,31	NF-kappaB	62,71	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
20378831	0	IkappaBalpha	63,75	NF-kappaB	14,23	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|responses responses|amod|END_ENTITY	Regulation of NF-kappaB responses by epigenetic suppression of IkappaBalpha expression in HCT116 intestinal epithelial cells .
20423347	0	IkappaBalpha	69,81	NF-kappaB	127,136	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY inhibiting|nsubj|degradation inhibiting|dobj|translocation translocation|nmod|END_ENTITY	Shikonin reduces oedema induced by phorbol_ester by interfering with IkappaBalpha degradation thus inhibiting translocation of NF-kappaB to the nucleus .
20696914	0	IkappaBalpha	117,129	NF-kappaB	33,42	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY enhancers|nmod|promoter mice|nmod|enhancers syndrome|nmod|mice underlies|dobj|syndrome underlies|nsubj|regulation regulation|nmod|END_ENTITY	Defective feedback regulation of NF-kappaB underlies Sjogren 's _ syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter .
21220295	0	IkappaBalpha	97,109	NF-kappaB	118,127	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	removes|nsubj|START_ENTITY removes|dobj|END_ENTITY	Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites .
21220295	0	IkappaBalpha	97,109	NF-kappaB	34,43	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	removes|nsubj|START_ENTITY provides|advcl|removes provides|nsubj|Detection Detection|nmod|complex complex|nmod|END_ENTITY	Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites .
8604224	0	IkappaBalpha	68,80	NF-kappaB	14,23	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	mutant|nmod|START_ENTITY activation|nmod|mutant activation|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of NF-kappaB activation by a dominant-negative mutant of IkappaBalpha .
9512545	0	IkappaBalpha	32,44	NF-kappaB	116,125	IkappaBalpha	NF-kappaB	4792	4790	Gene	Gene	degradation|nmod|START_ENTITY mediated|nsubjpass|degradation mediated|nmod|box box|acl:relcl|transferred transferred|nmod|END_ENTITY	Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB , bcl-3 or p53 .
9927206	0	IkappaBalpha	103,115	NF-kappaB	47,56	IkappaBalpha	NF-kappaB	18035(Tax:10090)	18033(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY inhibition|nmod|phosphorylation phorbol_ester|nmod|inhibition blocks|nmod|phorbol_ester blocks|dobj|activation activation|amod|END_ENTITY	Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol_ester via inhibition of IkappaBalpha phosphorylation and degradation .
10517905	0	IkappaBalpha	70,82	NF-kappaBp65	57,69	IkappaBalpha	NF-kappaBp65	4792	5970	Gene	Gene	system|compound|START_ENTITY effects|dep|system effects|nmod|END_ENTITY	Cell specific effects of glucocorticoid treatment on the NF-kappaBp65 / IkappaBalpha system in patients with Crohn 's _ disease .
10969074	0	IkappaBalpha	0,12	NF-kappa_B	31,41	IkappaBalpha	NF-kappa B	4792	4790	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	IkappaBalpha and IkappaBalpha / NF-kappa_B complexes are retained in the cytoplasm through interaction with a novel partner , RasGAP SH3-binding protein 2 .
12921778	0	IkappaBalpha	85,97	NFkappaB	45,53	IkappaBalpha	NFkappaB	4792	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Okadaic_acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils .
18981184	0	IkappaBalpha	33,45	SMAR1	17,22	IkappaBalpha	SMAR1	4792	54971	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions .
20309718	0	IkappaBalpha	105,117	THP-1	137,142	IkappaBalpha	THP-1	4792	2736	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|cells cells|compound|END_ENTITY	Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkappaBalpha phosphorylation in THP-1 cells .
20385620	0	IkappaBalpha	66,78	TNF-R1	86,92	IkappaBalpha	TNF-R1	4792	7132	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	RSK2 mediates NF - -LCB- kappa -RCB- B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway .
16050135	0	IkappaBalpha	7,19	VEGF	47,51	IkappaBalpha	VEGF	4792	7422	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells .
8657113	0	IkappaBalpha	19,31	casein_kinase_II	65,81	IkappaBalpha	casein kinase II	4792	1457	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein_kinase_II affects intrinsic protein stability .
15536134	0	IkappaBalpha	15,27	hes1	35,39	IkappaBalpha	hes1	18035(Tax:10090)	15205(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression .
17124531	0	IkappaBalpha	35,47	p105	66,70	IkappaBalpha	p105	4792	4790	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn_disease and ulcerative_colitis .
15969767	0	IkappaBalpha	30,42	p53	14,17	IkappaBalpha	p53	4792	7157	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Modulation of p53 activity by IkappaBalpha : evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors .
10224051	0	IkappaBbeta	8,19	NF-kappaB	41,50	IkappaBbeta	NF-kappaB	4793	4790	Gene	Gene	maintains|nsubj|START_ENTITY maintains|dobj|activation activation|amod|END_ENTITY	Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells .
11181838	0	IkappaBbeta	84,95	NF-kappaB	0,9	IkappaBbeta	NF-kappaB	4793	4790	Gene	Gene	association|nmod|START_ENTITY -LSB-|nsubj|association involved|parataxis|-LSB- involved|nsubjpass|END_ENTITY	NF-kappaB is involved in the survival of cerebellar granule neurons : association of IkappaBbeta -LSB- correction of Ikappabeta -RSB- phosphorylation with cell survival .
11571291	0	IkappaBbeta	0,11	NF-kappaB	118,127	IkappaBbeta	NF-kappaB	4793	4790	Gene	Gene	functions|nsubj|START_ENTITY functions|advcl|masking masking|dobj|sequences sequences|amod|END_ENTITY	IkappaBbeta , but not IkappaBalpha , functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells .
11571291	0	IkappaBbeta	0,11	NF-kappaB	85,94	IkappaBbeta	NF-kappaB	4793	4790	Gene	Gene	functions|nsubj|START_ENTITY functions|nmod|inhibitor inhibitor|nmod|dimers dimers|amod|END_ENTITY	IkappaBbeta , but not IkappaBalpha , functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells .
12672800	0	IkappaBbeta	125,136	NF-kappaB	139,148	IkappaBbeta	NF-kappaB	4793	4790	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes .
12686541	0	IkappaBbeta	30,41	NF-kappaB	44,53	IkappaBbeta	NF-kappaB	18036(Tax:10090)	18033(Tax:10090)	Gene	Gene	p65|compound|START_ENTITY p65|compound|END_ENTITY	X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex .
16792530	0	IkappaBbeta	36,47	NF-kappaB	19,28	IkappaBbeta	NF-kappaB	4793	4790	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	In vivo binding of NF-kappaB to the IkappaBbeta promoter is insufficient for transcriptional activation .
8628274	0	IkappaBbeta	16,27	NF-kappaB	138,147	IkappaBbeta	NF-kappaB	4793	4790	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|dep|mechanism mechanism|nmod|induction induction|nmod|END_ENTITY	Inactivation of IkappaBbeta by the tax protein of human_T-cell_leukemia_virus_type_1 : a potential mechanism for constitutive induction of NF-kappaB .
9621019	0	IkappaBbeta	108,119	RelA	25,29	IkappaBbeta	RelA	4793	5970	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|activation activation|nmod|END_ENTITY	Persistent activation of RelA by respiratory_syncytial_virus involves protein_kinase_C , underphosphorylated IkappaBbeta , and sequestration of protein phosphatase 2A by the viral phosphoprotein .
8628274	0	IkappaBbeta	16,27	tax	35,38	IkappaBbeta	tax	4793	1491938(Tax:11908)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Inactivation of IkappaBbeta by the tax protein of human_T-cell_leukemia_virus_type_1 : a potential mechanism for constitutive induction of NF-kappaB .
22291095	0	Ikaros	14,20	FoxO1	0,5	Ikaros	FoxO1	10320	2308	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination .
18287091	0	Ikaros	0,6	Hes1	48,52	Ikaros	Hes1	10320	3280	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line : implications for CD4 regulation .
19828627	0	Ikaros	0,6	Il10	25,29	Ikaros	Il10	22778(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Ikaros is a regulator of Il10 expression in CD4 + T cells .
17971486	0	Ikaros	63,69	Interferon_regulatory_factors_4_and_8	0,37	Ikaros	Interferon regulatory factors 4 and 8	10320	3662;3394	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Interferon_regulatory_factors_4_and_8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development .
16081070	0	Ikaros	72,78	STAT4	0,5	Ikaros	STAT4	10320	6775	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells .
11812772	0	Ikaros	119,125	Vasoactive_intestinal_peptide_receptor-1	0,40	Ikaros	Vasoactive intestinal peptide receptor-1	10320	7433	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- is a novel gene target of the hemolymphopoietic transcription factor Ikaros .
18818879	0	Ikaros	0,6	inducible_nitric_oxide_synthase	28,59	Ikaros	inducible nitric oxide synthase	10320	4843	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Ikaros negatively regulates inducible_nitric_oxide_synthase expression in macrophages : involvement of Ikaros phosphorylation by casein kinase 2 .
18818879	0	Ikaros	102,108	inducible_nitric_oxide_synthase	28,59	Ikaros	inducible nitric oxide synthase	10320	4843	Gene	Gene	phosphorylation|compound|START_ENTITY involvement|nmod|phosphorylation expression|dep|involvement expression|amod|END_ENTITY	Ikaros negatively regulates inducible_nitric_oxide_synthase expression in macrophages : involvement of Ikaros phosphorylation by casein kinase 2 .
16806387	0	Ikkepsilon	0,10	interferon_regulatory_factor-3	35,65	Ikkepsilon	interferon regulatory factor-3	9641	3661	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Ikkepsilon regulates viral-induced interferon_regulatory_factor-3 activation via a redox-sensitive pathway .
19265114	0	Il-10	90,95	CD4	128,131	Il-10	CD4	3586	920	Gene	Gene	production|nmod|START_ENTITY induce|dobj|production induce|nmod|cells cells|compound|END_ENTITY	Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10 , IFN-gamma , and IL-17A by naive CD4 + T cells .
11342660	0	Il-10	0,5	S100A8	61,67	Il-10	S100A8	16153(Tax:10090)	20201(Tax:10090)	Gene	Gene	up-regulates|amod|START_ENTITY macrophage|nsubj|up-regulates macrophage|dobj|expression expression|nmod|END_ENTITY	Il-10 up-regulates macrophage expression of the S100 protein S100A8 .
11160331	0	Il-10	0,5	cyclooxygenase-2	32,48	Il-10	cyclooxygenase-2	16153(Tax:10090)	19225(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Il-10 is a central regulator of cyclooxygenase-2 expression and prostaglandin production .
24278490	0	Il-13	104,109	Il-6	99,103	Il-13	Il-6	3596	3569	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Severe South American ocular_toxoplasmosis is associated with decreased Ifn-y/Il -17 a and increased Il-6 / Il-13 intraocular levels .
9206909	0	Il-1ra	52,58	Il-8	46,50	Il-1ra	Il-8	3557	3576	Gene	Gene	Il-6|appos|START_ENTITY Il-6|appos|END_ENTITY	-LSB- Changes in the cytokine concentration -LRB- Il-6 , Il-8 , _ Il-1ra -RRB- and their cellular expression of membrane molecules -LRB- CD25 , CD30 , HLA-DR -RRB- after surgical trauma -RSB- .
25443723	0	Il-2	24,28	Il-6	30,34	Il-2	Il-6	3558	3569	Gene	Gene	Il-1b|appos|START_ENTITY Il-1b|appos|END_ENTITY	Concentration of Il-1b , Il-2 , Il-6 , TNFa in the blood serum in children with generalized_epilepsy treated by valproate .
8525770	0	Il-2	25,29	Interleukin_2	1,14	Il-2	Interleukin 2	3558	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	-LSB- Interleukin_2 receptor -LRB- Il-2 -RRB- : structure and function -RSB- .
25443723	0	Il-2	24,28	TNFa	36,40	Il-2	TNFa	3558	7124	Gene	Gene	Il-1b|appos|START_ENTITY Il-1b|appos|END_ENTITY	Concentration of Il-1b , Il-2 , Il-6 , TNFa in the blood serum in children with generalized_epilepsy treated by valproate .
26569073	0	Il-33	11,16	St2	17,20	Il-33	St2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|pathway pathway|amod|END_ENTITY	Effects of Il-33 / St2 pathway on alteration of iron and hematological parameters in acute inflammation .
26684629	0	Il-4	76,80	Ccr4	70,74	Il-4	Ccr4	3565	1233	Gene	Gene	Il-13|dep|START_ENTITY Il-13|compound|END_ENTITY	Cd4 + Cd25 + Foxp3 + T regulatory cells , Th1 -LRB- Ccr5 , Il-2 , _ Ifn - -RRB- and Th2 -LRB- Ccr4 , Il-4 , Il-13 -RRB- type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency .
18392379	0	Il-6	31,35	CRP	85,88	Il-6	CRP	3569	1401	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of interleukin-6 -LRB- Il-6 -RRB- , interleukin-18 -LRB- Il-18 -RRB- and C-reactive_protein -LRB- CRP -RRB- in patients with type-2 diabetes and acute_coronary_syndrome without ST-segment elevation .
24278490	0	Il-6	99,103	Il-13	104,109	Il-6	Il-13	3569	3596	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Severe South American ocular_toxoplasmosis is associated with decreased Ifn-y/Il -17 a and increased Il-6 / Il-13 intraocular levels .
25443723	0	Il-6	30,34	Il-2	24,28	Il-6	Il-2	3569	3558	Gene	Gene	Il-1b|appos|START_ENTITY Il-1b|appos|END_ENTITY	Concentration of Il-1b , Il-2 , Il-6 , TNFa in the blood serum in children with generalized_epilepsy treated by valproate .
15575898	0	Il-6	35,39	STAT3	40,45	Il-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	induces|xcomp|START_ENTITY induces|dep|END_ENTITY	Severe preservation injury induces Il-6 / STAT3 activation with lack of cell cycle progression after partial liver graft transplantation .
11883273	0	Il-6	50,54	TNF-alpha	56,65	Il-6	TNF-alpha	3569	7124	Gene	Gene	Il-1_alpha|dep|START_ENTITY Il-1_alpha|dep|END_ENTITY	-LSB- Levels of proinflammatory cytokines -LRB- Il-1_alpha , Il-6 , TNF-alpha -RRB- in the semen plasma of male partners of infertile couples -RSB- .
25443723	0	Il-6	30,34	TNFa	36,40	Il-6	TNFa	3569	7124	Gene	Gene	Il-1b|appos|START_ENTITY Il-1b|appos|END_ENTITY	Concentration of Il-1b , Il-2 , Il-6 , TNFa in the blood serum in children with generalized_epilepsy treated by valproate .
11511101	0	Il-8	0,4	CXCR1	62,67	Il-8	CXCR1	3576	3577	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	Il-8 -LRB- -LRB- 3-73 -RRB- -RRB- K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2 .
9206909	0	Il-8	46,50	Il-1ra	52,58	Il-8	Il-1ra	3576	3557	Gene	Gene	Il-6|appos|START_ENTITY Il-6|appos|END_ENTITY	-LSB- Changes in the cytokine concentration -LRB- Il-6 , Il-8 , _ Il-1ra -RRB- and their cellular expression of membrane molecules -LRB- CD25 , CD30 , HLA-DR -RRB- after surgical trauma -RSB- .
12923954	0	Il-8	27,31	MCP-1	40,45	Il-8	MCP-1	3576	6347	Gene	Gene	Il-10|dep|START_ENTITY Il-10|dep|END_ENTITY	-LSB- Selected cytokines -LRB- Il-6 , Il-8 , Il-10 , MCP-1 , TNF-alpha -RRB- in children and adolescents with atherosclerosis risk factors : obesity , hypertension , diabetes -RSB- .
12923954	0	Il-8	27,31	TNF-alpha	47,56	Il-8	TNF-alpha	3576	7124	Gene	Gene	Il-10|dep|START_ENTITY Il-10|dep|END_ENTITY	-LSB- Selected cytokines -LRB- Il-6 , Il-8 , Il-10 , MCP-1 , TNF-alpha -RRB- in children and adolescents with atherosclerosis risk factors : obesity , hypertension , diabetes -RSB- .
19828627	0	Il10	25,29	Ikaros	0,6	Il10	Ikaros	16153(Tax:10090)	22778(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Ikaros is a regulator of Il10 expression in CD4 + T cells .
22786766	0	Il12b	16,21	IL-10	0,5	Il12b	IL-10	16160(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-10 regulates Il12b expression via histone deacetylation : implications for intestinal macrophage homeostasis .
21674483	0	Il17a	38,43	Mel-18	24,30	Il17a	Mel-18	3605	7703	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines .
18725523	0	Il2	27,30	Blimp-1	0,7	Il2	Blimp-1	16183(Tax:10090)	12142(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Blimp-1 directly represses Il2 and the Il2 activator Fos , attenuating T cell proliferation and survival .
9850165	0	Il6	20,23	CSF-1	0,5	Il6	CSF-1	16193(Tax:10090)	12977(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	CSF-1 regulation of Il6 gene expression by murine macrophages : a pivotal role for GM-CSF .
9850165	0	Il6	20,23	GM-CSF	82,88	Il6	GM-CSF	16193(Tax:10090)	12981(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|dep|role role|nmod|END_ENTITY	CSF-1 regulation of Il6 gene expression by murine macrophages : a pivotal role for GM-CSF .
24108699	0	Il9	54,57	Smad2	14,19	Il9	Smad2	3578	4087	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Cutting edge : Smad2 and Smad4 regulate TGF-b-mediated Il9 gene expression via EZH2 displacement .
23178405	0	Imd	51,54	zfh1	21,25	Imd	zfh1	44339(Tax:7227)	43650(Tax:7227)	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Transcription factor zfh1 downregulates Drosophila Imd pathway .
19197163	0	Ime2	52,56	Cdk2	6,10	Ime2	Cdk2	853338(Tax:4932)	1017	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Human Cdk2 is a functional homolog of budding yeast Ime2 , the meiosis-specific Cdk-like kinase .
21099355	0	Ime2	56,60	Cdk2	28,32	Ime2	Cdk2	853338(Tax:4932)	1017	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Ectopic expression of human Cdk2 and its yeast homolog , Ime2 , is deleterious to Saccharomyces_cerevisiae .
16776651	0	Ime2	25,29	Sic1	45,49	Ime2	Sic1	853338(Tax:4932)	850768(Tax:4932)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Saccharomyces_cerevisiae Ime2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation .
19087957	0	Ime2	45,49	Smk1	68,72	Ime2	Smk1	853338(Tax:4932)	856167(Tax:4932)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces_cerevisiae .
14612412	0	Ime2p	65,70	Cak1p	26,31	Ime2p	Cak1p	853338(Tax:4932)	850515(Tax:4932)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	The Cdk-activating kinase Cak1p promotes meiotic S phase through Ime2p .
20841378	0	Imh1p	64,69	Syt1p	0,5	Imh1p	Syt1p	851018(Tax:4932)	856210(Tax:4932)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p .
22157760	0	Iml3	77,81	Aft1	37,41	Iml3	Aft1	852404(Tax:4932)	852809(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Iron-responsive transcription factor Aft1 interacts with kinetochore protein Iml3 and promotes pericentromeric cohesin .
7473344	0	Immediate-early	0,15	interleukin-1_beta	44,62	Immediate-early	interleukin-1 beta	16476(Tax:10090)	16176(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|gene gene|amod|END_ENTITY	Immediate-early , transient induction of the interleukin-1_beta gene in mouse spleen macrophages by ionizing radiation .
25949126	0	Immortalization-Upregulated_Protein-2	10,47	IMUP-2	49,55	Immortalization-Upregulated Protein-2	IMUP-2	64073	64073	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of Immortalization-Upregulated_Protein-2 -LRB- IMUP-2 -RRB- on Cell Death of Trophoblast .
18094351	0	Immp2l	70,76	inner_mitochondrial_membrane_peptidase_2-like	18,63	Immp2l	inner mitochondrial membrane peptidase 2-like	93757(Tax:10090)	93757(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A mutation in the inner_mitochondrial_membrane_peptidase_2-like gene -LRB- Immp2l -RRB- affects mitochondrial function and impairs fertility in mice .
14500577	0	Immune-responsive_gene_1	0,24	progesterone_receptor	46,67	Immune-responsive gene 1	progesterone receptor	16365(Tax:10090)	18667(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Immune-responsive_gene_1 is a novel target of progesterone_receptor and plays a critical role during implantation in the mouse .
21757726	0	Immunity-related_GTPase_M	0,25	IRGM	27,31	Immunity-related GTPase M	IRGM	345611	345611	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Immunity-related_GTPase_M -LRB- IRGM -RRB- proteins influence the localization of guanylate-binding_protein_2 -LRB- GBP2 -RRB- by modulating macroautophagy .
23863714	0	Immunoglobulin-like_domain_containing_receptor_1	0,48	cholecystokinin	73,88	Immunoglobulin-like domain containing receptor 1	cholecystokinin	106347(Tax:10090)	12424(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|secretion secretion|compound|END_ENTITY	Immunoglobulin-like_domain_containing_receptor_1 mediates fat-stimulated cholecystokinin secretion .
24899637	0	Immunoglobulin-like_transcripts_6	0,33	ILT6	35,39	Immunoglobulin-like transcripts 6	ILT6	11026	11026	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Immunoglobulin-like_transcripts_6 -LRB- ILT6 -RRB- polymorphism influences the anti-Ro60 / 52 autoantibody status in South Indian SLE patients .
24701482	0	Immunoglobulin_E	25,41	IGE	43,46	Immunoglobulin E	IGE	3497	3497	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Role of Gender and Serum Immunoglobulin_E -LRB- IGE -RRB- levels on Severity of Migraine .
8188076	0	Immunosuppressive_acidic_protein	0,32	SCC	76,79	Immunosuppressive acidic protein	SCC	3375	6317	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Immunosuppressive_acidic_protein -LRB- IAP -RRB- and squamous_cell_carcinoma antigen -LRB- SCC -RRB- in patients with cervical_cancer .
18412985	0	Imp-L2	0,6	insulin	76,83	Imp-L2	insulin	38513(Tax:7227)	42549(Tax:7227)	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	Imp-L2 , a putative homolog of vertebrate IGF-binding protein 7 , counteracts insulin signaling in Drosophila and is essential for starvation resistance .
14990745	0	Imp4	40,44	Mpp10p	11,17	Imp4	Mpp10p	855649(Tax:4932)	853458(Tax:4932)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Two-hybrid Mpp10p interaction-defective Imp4 proteins are not interaction defective in vivo but do confer specific pre-rRNA processing defects in Saccharomyces_cerevisiae .
23934279	0	Importin-7	0,10	glucocorticoid_receptor	20,43	Importin-7	glucocorticoid receptor	10527	2908	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Importin-7 mediates glucocorticoid_receptor nuclear import and is impaired by oxidative stress , leading to glucocorticoid insensitivity .
17109628	0	Importin_alpha1	0,15	Zac1	101,105	Importin alpha1	Zac1	3838	5325	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Importin_alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1 .
25799587	0	Inactivation_No_Afterpotential_D	50,82	INAD	84,88	Inactivation No Afterpotential D	INAD	37629(Tax:7227)	37629(Tax:7227)	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	Light-Dependent Phosphorylation of the Drosophila Inactivation_No_Afterpotential_D -LRB- INAD -RRB- Scaffolding Protein at Thr170 and Ser174 by Eye-Specific Protein Kinase C. Drosophila inactivation_no_afterpotential_D -LRB- INAD -RRB- is a PDZ domain-containing scaffolding protein that tethers components of the phototransduction cascade to form a supramolecular signaling complex .
10369859	0	Incenp	110,116	inner_centromere_protein	79,103	Incenp	inner centromere protein	16319(Tax:10090)	16319(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Defective chromosome segregation , microtubule bundling and nuclear bridging in inner_centromere_protein gene -LRB- Incenp -RRB- - disrupted mice .
8810303	0	Inducible_cAMP_early_repressor	0,30	tyrosine_hydroxylase	44,64	Inducible cAMP early repressor	tyrosine hydroxylase	25620(Tax:10116)	25085(Tax:10116)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Inducible_cAMP_early_repressor can modulate tyrosine_hydroxylase gene expression after stimulation of cAMP synthesis .
11556540	0	Inducible_nitric_oxide_synthase	0,31	SOD1	132,136	Inducible nitric oxide synthase	SOD1	18126(Tax:10090)	20655(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and nitrotyrosine immunoreactivity in the spinal cords of transgenic_mice with a G93A mutant SOD1 gene .
19229714	0	Inducible_nitric_oxide_synthase	0,31	caspase-3	53,62	Inducible nitric oxide synthase	caspase-3	18126(Tax:10090)	12367(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Inducible_nitric_oxide_synthase mediates hippocampal caspase-3 activation in pneumococcal_meningitis .
10188914	0	Inducible_nitric_oxide_synthase	0,31	iNOS	33,37	Inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression may predict distant metastasis in human melanoma .
10779146	0	Inducible_nitric_oxide_synthase	0,31	iNOS	33,37	Inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression in liver and splenic T lymphocyte rise are associated with liver histological damage during experimental hepatitis_A_virus _ -LRB- HAV -RRB- _ infection in Callithrix_jacchus .
11971212	0	Inducible_nitric_oxide_synthase	0,31	iNOS	33,37	Inducible nitric oxide synthase	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression is increased in lipopolysaccharide -LRB- LPS -RRB- - stimulated diabetic rat glomeruli : effect of ACE inhibitor and angiotensin_II receptor blocker .
11852792	0	Indy	19,23	p115	24,28	Indy	p115	40049(Tax:7227)	31698(Tax:7227)	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	-LSB- Identification of Indy -LRB- p115 -RRB- mutation in the Na + - dicarboxylate transporter gene in Drosophila_melanogaster -RSB- .
25111790	0	Inhibin_alpha-subunit	0,21	INHA	23,27	Inhibin alpha-subunit	INHA	3623	3623	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibin_alpha-subunit -LRB- INHA -RRB- expression in adrenocortical_cancer is linked to genetic and epigenetic INHA promoter variation .
17426247	0	Inhibitor_of_DNA_binding_1	0,26	vascular_endothelial_growth_factor	37,71	Inhibitor of DNA binding 1	vascular endothelial growth factor	3397	7422	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Inhibitor_of_DNA_binding_1 activates vascular_endothelial_growth_factor through enhancing the stability and activity of hypoxia-inducible_factor-1alpha .
19618124	0	Inhibitor_of_DNA_binding_3	15,41	Id3	43,46	Inhibitor of DNA binding 3	Id3	3399	3399	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of Inhibitor_of_DNA_binding_3 -LRB- Id3 -RRB- with Gut-enriched Kr ppel-like factor -LRB- GKLF -RRB- and p53 regulates proliferation of vascular smooth muscle cells .
11377392	0	Inhibitor_of_apoptosis-1	0,24	IAP-1	26,31	Inhibitor of apoptosis-1	IAP-1	330	330	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibitor_of_apoptosis-1 -LRB- IAP-1 -RRB- expression and apoptosis in non-small-cell lung_cancer cells exposed to gemcitabine .
12833149	0	Inhibitor_of_apoptosis_protein	0,30	IAP	32,35	Inhibitor of apoptosis protein	IAP	84061	84061	Gene	Gene	survivin|amod|START_ENTITY survivin|appos|END_ENTITY	Inhibitor_of_apoptosis_protein -LRB- IAP -RRB- survivin is upregulated by oncogenic c-H-Ras .
22923192	0	Inhibitor_of_apoptosis_protein	0,30	IAP	32,35	Inhibitor of apoptosis protein	IAP	961	961	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Inhibitor_of_apoptosis_protein -LRB- IAP -RRB- antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy .
19486931	0	Inhibitor_of_differentiation_1	0,30	Id1	32,35	Inhibitor of differentiation 1	Id1	3397	3397	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibitor_of_differentiation_1 -LRB- Id1 -RRB- expression attenuates the degree of TiO2-induced cytotoxicity in H1299 non-small_cell_lung_cancer cells .
26379191	0	Inhibitory_PAS_domain_protein	0,29	PINK1	48,53	Inhibitory PAS domain protein	PINK1	64344	65018	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Inhibitory_PAS_domain_protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson 's _ disease model .
9704925	0	Ink4	19,23	p16	33,36	Ink4	p16	1029	1029	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence .
11897669	8	Ink4B	1165,1170	p15	1161,1164	Ink4B	p15	1030	1030	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	p15 -LRB- Ink4B -RRB- mRNA is also up-regulated with TGF_beta 1 treatment in OC2-9 , whereas the p15 -LRB- Ink4B -RRB- gene has been deleted in OC1 , CaOV3 , and SkOV3 cells .
10964101	0	Ink4a	29,34	p16	24,27	Ink4a	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Hypermethylation of the p16 -LRB- Ink4a -RRB- promoter in B6C3F1 mouse primary lung_adenocarcinomas and mouse lung cell lines .
11163109	0	Ink4a	23,28	p16	19,22	Ink4a	p16	1029	1029	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Methylation of the p16 -LRB- Ink4a -RRB- tumor suppressor gene 5 ' - CpG island in breast_cancer .
15534905	0	Ink4a	65,70	p16	61,64	Ink4a	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Microarray-based method for detecting methylation changes of p16 -LRB- Ink4a -RRB- gene 5 ' - CpG islands in gastric_carcinomas .
21423154	0	Ink4a	29,34	p16	25,28	Ink4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Up and downregulation of p16 -LRB- Ink4a -RRB- expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon_cancer .
22659510	0	Ink4a	84,89	p16	80,83	Ink4a	p16	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	Cdkn2a|appos|START_ENTITY Cdkn2a|dep|END_ENTITY	Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a -LRB- p16 -LRB- Ink4a -RRB- -RRB- in early-stage liver_tumor-promotion facilitating liver cell regeneration in rats .
11756558	0	Ink4a	23,28	p53	43,46	Ink4a	p53	12578(Tax:10090)	22060(Tax:10090)	Gene	Gene	p16|appos|START_ENTITY roles|nmod|p16 roles|dep|END_ENTITY	Obligate roles for p16 -LRB- Ink4a -RRB- and p19 -LRB- Arf -RRB- - p53 in the suppression of murine pancreatic neoplasia .
18983959	0	Ink4a/Arf	0,9	let-7b	24,30	Ink4a/Arf	let-7b	12578(Tax:10090)	387245(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Ink4a/Arf regulation by let-7b and Hmga2 : a genetic pathway governing stem cell aging .
23536791	0	Ink4d	49,54	p19	45,48	Ink4d	p19	1032	1032	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Polypyrimidine_tract-binding_protein induces p19 -LRB- Ink4d -RRB- expression and inhibits the proliferation of H1299 cells .
26607847	0	Inka1	70,75	PAK4	35,39	Inka1	PAK4	389119	10298	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 .
22182244	0	Ino2p	74,79	PHO5	57,61	Ino2p	PHO5	851701(Tax:4932)	852390(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcription regulation of the Saccharomyces_cerevisiae PHO5 gene by the Ino2p and Ino4p basic helix-loop-helix proteins .
25476455	0	Inositol_Polyphosphate-5-Phosphatase_F	0,38	STAT3	57,62	Inositol Polyphosphate-5-Phosphatase F	STAT3	22876	6774	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Inositol_Polyphosphate-5-Phosphatase_F -LRB- INPP5F -RRB- inhibits STAT3 activity and suppresses gliomas_tumorigenicity .
16678774	0	Inp2p	33,38	Myo2p	98,103	Inp2p	Myo2p	855198(Tax:4932)	854504(Tax:4932)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces_cerevisiae .
10610720	0	Inppl1	17,23	SHIP2	10,15	Inppl1	SHIP2	16332(Tax:10090)	16332(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse SHIP2 -LRB- Inppl1 -RRB- gene : complementary DNA , genomic structure , promoter analysis , and gene expression in the embryo and adult mouse .
10868937	0	Ins-1	73,78	IGF-I	21,26	Ins-1	IGF-I	24505(Tax:10116)	24482(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Inhibitory effect of IGF-I on type 2 nitric_oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis : involvement of phosphatidylinositol 3-kinase .
1358794	0	Ins-2	27,32	tub	64,67	Ins-2	tub	16334(Tax:10090)	22141(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of insulin-2 -LRB- Ins-2 -RRB- and the obesity mutant tubby -LRB- tub -RRB- to distinct regions of mouse chromosome 7 .
10591217	0	Inscuteable	17,28	Bazooka	0,7	Inscuteable	Bazooka	37355(Tax:7227)	32703(Tax:7227)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts .
25109869	0	Insig-1	72,79	SREBP-1c	80,88	Insig-1	SREBP-1c	64194(Tax:10116)	78968(Tax:10116)	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	Silibinin protects b cells from glucotoxicity through regulation of the Insig-1 / SREBP-1c pathway .
18187584	0	Insig-1	135,142	pregnane_X_receptor	106,125	Insig-1	pregnane X receptor	231070(Tax:10090)	18171(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulatory cross-talk between drug metabolism and lipid homeostasis : constitutive_androstane_receptor and pregnane_X_receptor increase Insig-1 expression .
26694996	0	Insig-2	117,124	SREBP-2	125,132	Insig-2	SREBP-2	51141	6721	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	Increase of circulating cholesterol in vitamin_D deficiency is linked to reduced vitamin_D_receptor activity via the Insig-2 / SREBP-2 pathway .
10650968	0	Insl3	38,43	insulin-like_factor_3	15,36	Insl3	insulin-like factor 3	16336(Tax:10090)	16336(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of insulin-like_factor_3 -LRB- Insl3 -RRB- in diethylstilbestrol-induced cryptorchidism .
25828096	0	Insm1	0,5	Neurod1	22,29	Insm1	Neurod1	53626(Tax:10090)	18012(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic b-cell function .
26105159	0	Insulin	35,42	AMPK	27,31	Insulin	AMPK	3630	5563	Gene	Gene	Expression|compound|START_ENTITY Effects|nmod|Expression Effects|nmod|END_ENTITY	The Paradoxical Effects of AMPK on Insulin Gene Expression and Glucose-Induced Insulin Secretion .
6433906	0	Insulin	0,7	ATP-citrate_lyase	74,91	Insulin	ATP-citrate lyase	3630	47	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Insulin stimulates the dephosphorylation of phosphothreonine from fat-pad ATP-citrate_lyase .
24065958	0	Insulin	151,158	Adiponectin	28,39	Insulin	Adiponectin	101334138	9370	Gene	Gene	Resistance|compound|START_ENTITY Measurements|nmod|Resistance Measurements|nmod|END_ENTITY	Ratiometric Measurements of Adiponectin by Mass Spectrometry in Bottlenose Dolphins -LRB- Tursiops_truncatus -RRB- with Iron Overload Reveal an Association with Insulin Resistance and Glucagon .
12895435	0	Insulin	0,7	Akt	118,121	Insulin	Akt	3630	207	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|dep|role role|nmod|END_ENTITY	Insulin enhances the expression of the endothelial_nitric_oxide_synthase in native endothelial cells : a dual role for Akt and AP-1 .
19318457	0	Insulin	0,7	Akt	60,63	Insulin	Akt	3630	207	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|factor-I factor-I|dep|pathway pathway|compound|END_ENTITY	Insulin attenuates the insulin-like growth factor-I -LRB- IGF-I -RRB- - Akt pathway , not IGF-I-extracellularly regulated kinase pathway , in luteinized granulosa cells with an increase in PTEN .
21871446	0	Insulin	0,7	Akt	86,89	Insulin	Akt	3630	207	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|cells cells|nmod|END_ENTITY	Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt .
26465605	0	Insulin	10,17	Akt	0,3	Insulin	Akt	3630	207	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Akt Links Insulin Signaling to Albumin Endocytosis in Proximal Tubule Epithelial Cells .
25750761	0	Insulin	75,82	Amylin	7,13	Insulin	Amylin	3630	3375	Gene	Gene	Treatment|compound|START_ENTITY END_ENTITY|nmod|Treatment	Plasma Amylin and Cognition in Diabetes in the Absence and the Presence of Insulin Treatment .
18441389	0	Insulin	0,7	CD36	77,81	Insulin	CD36	3630	948	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Insulin acutely upregulates protein expression of the fatty_acid transporter CD36 in human skeletal muscle in vivo .
20517899	0	Insulin	0,7	ERK	72,75	Insulin	ERK	3630	5594	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells .
26549747	0	Insulin	0,7	FGF2	34,38	Insulin	FGF2	3630	2247	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Insulin induces the expression of FGF2 but does not synergize with it during angiogenesis .
19608644	0	Insulin	0,7	FOXO3a	21,27	Insulin	FOXO3a	3630	2309	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Insulin acts through FOXO3a to activate transcription of plasminogen activator inhibitor type 1 .
26018652	0	Insulin	13,20	FTO	0,3	Insulin	FTO	3630	79068	Gene	Gene	Secretion|compound|START_ENTITY Inhibits|dobj|Secretion Inhibits|nsubj|END_ENTITY	FTO Inhibits Insulin Secretion and Promotes NF-kB Activation through Positively Regulating ROS Production in Pancreatic b cells .
26018652	0	Insulin	13,20	FTO	0,3	Insulin	FTO	3630	79068	Gene	Gene	Secretion|compound|START_ENTITY Inhibits|dobj|Secretion Inhibits|nsubj|END_ENTITY	FTO Inhibits Insulin Secretion and Promotes NF-kB Activation through Positively Regulating ROS Production in Pancreatic b cells .
24551104	0	Insulin	0,7	FoxO1	68,73	Insulin	FoxO1	3630	2308	Gene	Gene	rescue|nsubj|START_ENTITY rescue|dobj|differentiation differentiation|nmod|myoblasts myoblasts|amod|END_ENTITY	Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts .
25091498	0	Insulin	0,7	FoxO1	103,108	Insulin	FoxO1	3630	2308	Gene	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|nmod|regulation regulation|nmod|END_ENTITY	Insulin drives glucose-dependent_insulinotropic_peptide expression via glucose-dependent regulation of FoxO1 and LEF1/b-catenin .
25627686	0	Insulin	0,7	FoxO1	100,105	Insulin	FoxO1	3630	2308	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Insulin Regulates Retinol_Dehydrogenase Expression and All-trans-retinoic_Acid Biosynthesis through FoxO1 .
26929406	0	Insulin	186,193	FoxO1	38,43	Insulin	FoxO1	3630	2308	Gene	Gene	Genes|compound|START_ENTITY Forkhead|nmod|Genes Forkhead|nsubj|Loss Loss|nmod|Binding Binding|nmod|END_ENTITY	Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin Sensitive Genes .
14500912	0	Insulin	0,7	Foxa-2	74,80	Insulin	Foxa-2	3630	3170	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Insulin regulates the activity of forkhead transcription factor Hnf-3beta / Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization .
23997935	0	Insulin	0,7	GLP-1	146,151	Insulin	GLP-1	3630	2641	Gene	Gene	infusions|compound|START_ENTITY demonstrate|nsubj|infusions demonstrate|nmod|mammal mammal|dep|role role|nmod|END_ENTITY	Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal : potential glucogenic role for GLP-1 .
25825945	0	Insulin	78,85	GLP-1	22,27	Insulin	GLP-1	3630	2641	Gene	Gene	Sensitivity|compound|START_ENTITY Variable|nmod|Sensitivity Variable|nsubj|Sensitivity Sensitivity|nmod|END_ENTITY	b-Cell Sensitivity to GLP-1 in Healthy Humans Is Variable and Proportional to Insulin Sensitivity .
26225223	0	Insulin	117,124	GLP-1	17,22	Insulin	GLP-1	3630	2641	Gene	Gene	Model|compound|START_ENTITY Diabetes_Mellitus|nmod|Model Diabetes_Mellitus|nsubj|Effects Effects|nmod|Analog Analog|compound|END_ENTITY	The Effects of a GLP-1 Analog on Glucose Homeostasis in Type 2 Diabetes_Mellitus Quantified by an Integrated Glucose Insulin Model .
26908914	0	Insulin	23,30	GLP-1	0,5	Insulin	GLP-1	3630	100125288	Gene	Gene	Restores|dobj|START_ENTITY Restores|nsubj|END_ENTITY	GLP-1 Restores Altered Insulin and Glucagon Secretion_in_Posttransplantation_Diabetes .
25897187	0	Insulin	47,54	GLP-1_Receptor	7,21	Insulin	GLP-1 Receptor	3630	2740	Gene	Gene	Therapy|nmod|START_ENTITY Therapy|compound|END_ENTITY	Adding GLP-1_Receptor Agonist Therapy to Basal Insulin for Postprandial Glucose Control .
21291866	0	Insulin	0,7	GLT1	40,44	Insulin	GLT1	3630	6506	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Insulin increases glutamate transporter GLT1 in cultured astrocytes .
12641495	0	Insulin	0,7	GLUT4	33,38	Insulin	GLUT4	3630	6517	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Insulin and dexamethasone induce GLUT4 gene expression in foetal brown adipocytes : synergistic effect through CCAAT/enhancer-binding _ protein_alpha .
1521731	0	Insulin	0,7	GLUT_4	61,67	Insulin	GLUT 4	3630	6517	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Insulin receptor and insulin-responsive glucose transporter -LRB- GLUT_4 -RRB- mutations and polymorphisms in a Welsh type 2 -LRB- non-insulin-dependent -RRB- diabetic population .
18031314	0	Insulin	0,7	IGFBP-1	22,29	Insulin	IGFBP-1	3630	3484	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Insulin , adiponectin , IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages .
18082128	0	Insulin	52,59	INS-1	109,114	Insulin	INS-1	3630	2305	Gene	Gene	secretagogues|compound|START_ENTITY alter|nsubj|secretagogues alter|dobj|composition composition|nmod|cells cells|compound|END_ENTITY	The role of rapid lipogenesis in insulin secretion : Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells .
21076579	0	Insulin	65,72	INS-1	92,97	Insulin	INS-1	3630	2305	Gene	Gene	Expression|compound|START_ENTITY Tribbles-Related_Protein_3|nmod|Expression Effect|nmod|Tribbles-Related_Protein_3 Effect|nmod|Cells Cells|compound|END_ENTITY	The Effect of Tribbles-Related_Protein_3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells .
25310693	0	Insulin	27,34	INS-1	64,69	Insulin	INS-1	3630	2305	Gene	Gene	Dynamics|compound|START_ENTITY Dependence|nmod|Dynamics Dependence|nmod|Beta-Cells Beta-Cells|compound|END_ENTITY	Cytoskeletal Dependence of Insulin Granule Movement Dynamics in INS-1 Beta-Cells in Response to Glucose .
26986474	0	Insulin	62,69	INS-1	83,88	Insulin	INS-1	3630	2305	Gene	Gene	Secretion|compound|START_ENTITY Secretion|nmod|END_ENTITY	Rosuvastatin Treatment Affects Both Basal and Glucose-Induced Insulin Secretion in INS-1 832/13 Cells .
26432623	0	Insulin	14,21	Insulin	37,44	Insulin	Insulin	3630	3630	Gene	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Sliding Scale Insulin vs Basal-Bolus Insulin Therapy in Long-Term Care : A 21-Day Randomized Controlled Trial Comparing Efficacy , Safety and Feasibility .
26432623	0	Insulin	37,44	Insulin	14,21	Insulin	Insulin	3630	3630	Gene	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Sliding Scale Insulin vs Basal-Bolus Insulin Therapy in Long-Term Care : A 21-Day Randomized Controlled Trial Comparing Efficacy , Safety and Feasibility .
26625003	0	Insulin	178,185	Insulin	211,218	Insulin	Insulin	3630	3630	Gene	Gene	Therapy|compound|START_ENTITY Therapy|nmod|END_ENTITY	Can Fasting Glucose Levels or Post-Breakfast Glucose Fluctuations Predict the Occurrence of Nocturnal Asymptomatic Hypoglycemia in Type 1 Diabetic Patients Receiving Basal-Bolus Insulin Therapy with Long-Acting Insulin ?
26625003	0	Insulin	211,218	Insulin	178,185	Insulin	Insulin	3630	3630	Gene	Gene	Therapy|nmod|START_ENTITY Therapy|compound|END_ENTITY	Can Fasting Glucose Levels or Post-Breakfast Glucose Fluctuations Predict the Occurrence of Nocturnal Asymptomatic Hypoglycemia in Type 1 Diabetic Patients Receiving Basal-Bolus Insulin Therapy with Long-Acting Insulin ?
25101056	0	Insulin	59,66	Insulin_Receptor	31,47	Insulin	Insulin Receptor	100060077(Tax:9796)	100066248(Tax:9796)	Gene	Gene	Binding|compound|START_ENTITY Binding|compound|END_ENTITY	Estradiol Binds to Insulin and Insulin_Receptor Decreasing Insulin Binding in vitro .
26600183	0	Insulin	0,7	Interferon-a	52,64	Insulin	Interferon-a	3630	3440	Gene	Gene	Response|compound|START_ENTITY Response|nmod|END_ENTITY	Insulin Resistance Predicts Virological Response to Interferon-a in Chronic Hepatitis_B Patients .
21461291	0	Insulin	15,22	Interleukin-6	45,58	Insulin	Interleukin-6	3630	3569	Gene	Gene	Association|nmod|START_ENTITY Resistance|nsubj|Association Resistance|nmod|END_ENTITY	Association of Insulin Resistance with Serum Interleukin-6 and TNF-a Levels During Normal Pregnancy .
25821463	0	Insulin	95,102	Leptin	21,27	Insulin	Leptin	3630	3952	Gene	Gene	Resistance|compound|START_ENTITY Variations|nmod|Resistance Variations|compound|END_ENTITY	HOMA , BMI , and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic , Nonobese , and Nondiabetic_Chronic_Hepatitis_C Genotype 1 Patients .
18270300	0	Insulin	0,7	MCP-1	22,27	Insulin	MCP-1	3630	6347	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Insulin regulation of MCP-1 in human adipose tissue of obese and lean women .
11232040	0	Insulin	0,7	NFkappaB	17,25	Insulin	NFkappaB	3630	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells .
10672002	0	Insulin	0,7	NHE1	19,23	Insulin	NHE1	3630	6548	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein_kinase_C zeta in human erythrocytes .
12208671	0	Insulin	0,7	P450_aromatase	59,73	Insulin	P450 aromatase	280829(Tax:9913)	281740(Tax:9913)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	Insulin and IGF-I are necessary for FSH-induced cytochrome P450_aromatase but not cytochrome P450 side-chain cleavage gene expression in oestrogenic bovine granulosa cells in vitro .
16375695	0	Insulin	0,7	PEPCK	22,27	Insulin	PEPCK	3630	5106	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Insulin regulation of PEPCK gene expression : a model for rapid and reversible modulation .
12007784	0	Insulin	0,7	PFKFB3	16,22	Insulin	PFKFB3	3630	5209	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Insulin induces PFKFB3 gene expression in HT29 human colon_adenocarcinoma cells .
18518905	0	Insulin	0,7	PI3-K	68,73	Insulin	PI3-K	3630	5293	Gene	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	Insulin blocks cytochrome_c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding .
26712196	0	Insulin	11,18	Part_1	42,48	Insulin	Part 1	3630	25859	Gene	Gene	Misperceptions|compound|START_ENTITY Misperceptions|dep|END_ENTITY	Addressing Insulin Misperceptions -LRB- AIM -RRB- - Part_1 .
17158802	0	Insulin	0,7	Pdx1	43,47	Insulin	Pdx1	3630	3651	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|nmod|END_ENTITY	Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome .
24969115	0	Insulin	17,24	Pen	25,28	Insulin	Pen	3630	340348	Gene	Gene	Errors|compound|START_ENTITY Errors|compound|END_ENTITY	A New `` Twist '' on Insulin Pen Administrat ion Errors .
25662503	0	Insulin	23,30	Pen	59,62	Insulin	Pen	3630	340348	Gene	Gene	Delivered|compound|START_ENTITY Delivered|nmod|Needle Needle|compound|END_ENTITY	Safety and Efficacy of Insulin Therapy Delivered via a 4mm Pen Needle in Obese Patients With Diabetes .
25673892	0	Insulin	71,78	Pen	35,38	Insulin	Pen	3630	340348	Gene	Gene	Delivery|compound|START_ENTITY Impact|nmod|Delivery Impact|acl|Converting Converting|nmod|Vial Vial|amod|END_ENTITY	Economic Impact of Converting from Pen and 10-mL Vial to 3-mL Vial for Insulin Delivery in a Hospital Setting .
26085903	0	Insulin	13,20	Pen	21,24	Insulin	Pen	3630	340348	Gene	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Adherence to Insulin Pen Therapy Is Associated with Reduction in Healthcare Costs Among Patients with Type_2_Diabetes_Mellitus .
26078977	0	Insulin	34,41	RAGE	24,28	Insulin	RAGE	3630	101669765	Gene	Gene	Resistance|compound|START_ENTITY END_ENTITY|nmod|Resistance	Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type_2_Diabetes_Mellitus .
19996311	0	Insulin	0,7	REDD1	16,21	Insulin	REDD1	3630	54541	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Insulin induces REDD1 expression through hypoxia-inducible_factor_1 activation in adipocytes .
25497100	0	Insulin	15,22	RFX6	0,4	Insulin	RFX6	3630	222546	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	RFX6 Regulates Insulin Secretion by Modulating Ca -LRB- 2 + -RRB- Homeostasis in Human b Cells .
25128719	0	Insulin	10,17	Resistin	0,8	Insulin	Resistin	3630	56729	Gene	Gene	resistance|amod|START_ENTITY END_ENTITY|dep|resistance	Resistin : Insulin resistance to malignancy .
25627686	0	Insulin	0,7	Retinol_Dehydrogenase	18,39	Insulin	Retinol Dehydrogenase	3630	131	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Insulin Regulates Retinol_Dehydrogenase Expression and All-trans-retinoic_Acid Biosynthesis through FoxO1 .
12820960	0	Insulin	0,7	Rheb	22,26	Insulin	Rheb	3630	6009	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Insulin activation of Rheb , a mediator of mTOR/S6K/4E-BP signaling , is inhibited by TSC1_and_2 .
26515129	0	Insulin	0,7	Rip11	17,22	Insulin	Rip11	3630	26056	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|amod|END_ENTITY	Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin - and PI3-kinase-dependent , but Akt-independent , internalisation event .
17668875	0	Insulin	103,110	SOCS3	36,41	Insulin	SOCS3	3630	9021	Gene	Gene	resistance|compound|START_ENTITY expression|dep|resistance expression|appos|END_ENTITY	Suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- expression and hepatitis_C virus-related chronic hepatitis : Insulin resistance and response to antiviral therapy .
12890573	0	Insulin	0,7	STAT3	34,39	Insulin	STAT3	3630	6774	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|tyrosine-phosphorylation tyrosine-phosphorylation|compound|END_ENTITY	Insulin attenuates leptin-induced STAT3 tyrosine-phosphorylation in a hepatoma cell line .
8647800	0	Insulin	0,7	STAT3	103,108	Insulin	STAT3	3630	6774	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|isoform isoform|appos|END_ENTITY	Insulin stimulates the serine phosphorylation of the signal_transducer_and_activator_of_transcription -LRB- STAT3 -RRB- isoform .
10618497	0	Insulin	0,7	STAT5b	30,36	Insulin	STAT5b	3630	6777	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Insulin selectively activates STAT5b , but not STAT5a , via a JAK2-independent signalling pathway in Kym-1 rhabdomyosarcoma cells .
19006485	0	Insulin	0,7	Sec8	62,66	Insulin	Sec8	3630	60412	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes .
11278505	0	Insulin	0,7	Shc	46,49	Insulin	Shc	3630	6464	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|prenyltransferases prenyltransferases|nmod|branch branch|compound|END_ENTITY	Insulin signals to prenyltransferases via the Shc branch of intracellular signaling .
26714029	0	Insulin	28,35	Sirt1	12,17	Insulin	Sirt1	3630	23411	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Correction : Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells .
9399641	0	Insulin	0,7	Stat3	18,23	Insulin	Stat3	3630	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction .
12912916	0	Insulin	0,7	TC10	67,71	Insulin	TC10	3630	23433	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation .
17352408	0	Insulin	0,7	TRAIL	23,28	Insulin	TRAIL	3630	246775(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro .
19164449	0	Insulin	0,7	TRB3	18,22	Insulin	TRB3	3630	57761	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta .
12820960	0	Insulin	0,7	TSC1_and_2	84,94	Insulin	TSC1 and 2	3630	7248;7249	Gene	Gene	activation|compound|START_ENTITY inhibited|nsubjpass|activation inhibited|nmod|END_ENTITY	Insulin activation of Rheb , a mediator of mTOR/S6K/4E-BP signaling , is inhibited by TSC1_and_2 .
21076579	0	Insulin	65,72	Tribbles-Related_Protein_3	14,40	Insulin	Tribbles-Related Protein 3	3630	57761	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	The Effect of Tribbles-Related_Protein_3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells .
26714029	0	Insulin	28,35	UCP2	60,64	Insulin	UCP2	3630	7351	Gene	Gene	Secretion|compound|START_ENTITY Secretion|nmod|END_ENTITY	Correction : Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells .
26848765	0	Insulin	40,47	UCP3	32,36	Insulin	UCP3	3630	7352	Gene	Gene	Resistance|compound|START_ENTITY END_ENTITY|nmod|Resistance	Effect of -55 CT Polymorphism of UCP3 on Insulin Resistance and Cardiovascular Risk Factors after a High Protein/Low Carbohydrate versus a Standard Hypocaloric Diet .
23698113	0	Insulin	0,7	VEGF-A	28,34	Insulin	VEGF-A	3630	22339(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Insulin directly stimulates VEGF-A production in the glomerular podocyte .
12660877	0	Insulin	0,7	adiponectin	24,35	Insulin	adiponectin	3630	9370	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|levels levels|compound|END_ENTITY	Insulin decreases human adiponectin plasma levels .
18031314	0	Insulin	0,7	adiponectin	9,20	Insulin	adiponectin	3630	9370	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Insulin , adiponectin , IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages .
18208577	0	Insulin	0,7	adiponectin	38,49	Insulin	adiponectin	3630	9370	Gene	Gene	effect|compound|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Insulin effect on adipose_tissue -LRB- AT -RRB- adiponectin expression is regulated by the insulin resistance status of the patients .
21156037	0	Insulin	0,7	adiponectin	20,31	Insulin	adiponectin	3630	9370	Gene	Gene	outcomes|compound|START_ENTITY outcomes|compound|END_ENTITY	Insulin resistance , adiponectin and adverse outcomes following elective cardiac surgery : a prospective follow-up study .
23431015	0	Insulin	0,7	adiponectin	22,33	Insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY resistance|nmod|deficiency deficiency|compound|END_ENTITY	Insulin resistance by adiponectin deficiency : is the action in skeletal muscle ?
24973036	0	Insulin	0,7	adiponectin	67,78	Insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nsubj|resistance	Insulin resistance and its relationship with high molecular weight adiponectin in adolescents with polycystic_ovary_syndrome and a maternal history of polycystic_ovary_syndrome .
25286962	0	Insulin	0,7	adiponectin	61,72	Insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY resistance|dep|relation relation|nmod|END_ENTITY	Insulin resistance in patients on valproic_acid : relation to adiponectin .
2679882	0	Insulin	0,7	adipsin	40,47	Insulin	adipsin	3630	1675	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes .
14617233	0	Insulin	0,7	angiotensinogen	18,33	Insulin	angiotensinogen	3630	183	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Insulin increases angiotensinogen expression in human abdominal subcutaneous adipocytes .
9735335	0	Insulin	0,7	angiotensinogen	23,38	Insulin	angiotensinogen	3630	183	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	Insulin down-regulates angiotensinogen gene expression and angiotensinogen secretion in cultured adipose cells .
7512956	0	Insulin	0,7	c-Jun	38,43	Insulin	c-Jun	3630	3725	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Insulin stimulates phosphorylation of c-Jun , c-Fos , and Fos-related proteins in cultured adipocytes .
24843127	0	Insulin	0,7	carboxypeptidase_E	18,36	Insulin	carboxypeptidase E	3630	1363	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Insulin regulates carboxypeptidase_E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic b cells .
16885156	0	Insulin	0,7	cholesterol_7alpha-hydroxylase	22,52	Insulin	cholesterol 7alpha-hydroxylase	3630	1581	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Insulin regulation of cholesterol_7alpha-hydroxylase expression in human hepatocytes : roles of forkhead_box_O1 and sterol regulatory element-binding protein 1c .
3313393	0	Insulin	0,7	choline_acetyltransferase	19,44	Insulin	choline acetyltransferase	396145(Tax:9031)	395314(Tax:9031)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Insulin stimulates choline_acetyltransferase activity in cultured embryonic_chicken_retina_neurons .
9806796	0	Insulin	0,7	delta-aminolevulinate_synthase	17,47	Insulin	delta-aminolevulinate synthase	3630	211	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Insulin inhibits delta-aminolevulinate_synthase gene expression in rat hepatocytes and human hepatoma cells .
22236491	0	Insulin	0,7	elastin	34,41	Insulin	elastin	3630	2006	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Insulin induces production of new elastin in cultures of human aortic smooth muscle cells .
12895435	0	Insulin	0,7	endothelial_nitric_oxide_synthase	39,72	Insulin	endothelial nitric oxide synthase	3630	4846	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Insulin enhances the expression of the endothelial_nitric_oxide_synthase in native endothelial cells : a dual role for Akt and AP-1 .
10458717	0	Insulin	0,7	endothelin	24,34	Insulin	endothelin	3630	1906	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Insulin stimulates both endothelin and nitric_oxide activity in the human forearm .
7883838	0	Insulin	0,7	endothelin-1	19,31	Insulin	endothelin-1	3630	1906	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo .
8345807	0	Insulin	0,7	endothelin-1	30,42	Insulin	endothelin-1	3630	1906	Gene	Gene	modulates|nsubj|START_ENTITY modulates|xcomp|circulating circulating|dobj|levels levels|amod|END_ENTITY	Insulin modulates circulating endothelin-1 levels in humans .
1947790	0	Insulin	0,7	epidermal_growth_factor	17,40	Insulin	epidermal growth factor	100379579(Tax:10141)	100714471	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|growth growth|amod|END_ENTITY	Insulin enhances epidermal_growth_factor - and transforming_growth_factor-alpha-stimulated growth in primary cultures of guinea_pig gastric mucous epithelial cells .
8760113	0	Insulin	0,7	epidermal_growth_factor	40,63	Insulin	epidermal growth factor	100379579(Tax:10141)	100714471	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|effect effect|nmod|END_ENTITY	Insulin potentiates mitogenic effect of epidermal_growth_factor on cultured guinea_pig gastric mucous cells .
17274952	0	Insulin	0,7	epiregulin	48,58	Insulin	epiregulin	3630	2069	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Insulin induces a transcriptional activation of epiregulin , HB-EGF and amphiregulin , by a PI3K-dependent mechanism : identification of a specific insulin-responsive promoter element .
21904878	0	Insulin	0,7	glucagon-like_peptide-1	75,98	Insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	contributes|nsubj|START_ENTITY contributes|xcomp|fine-tuning fine-tuning|nmod|END_ENTITY	Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like_peptide-1 .
9921815	0	Insulin	0,7	glucagon-like_peptide-1	52,75	Insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	calcium|compound|START_ENTITY responsiveness|nsubj|calcium responsiveness|xcomp|END_ENTITY	Insulin and intracellular calcium responsiveness to glucagon-like_peptide-1 and pituitary_adenylate_cyclase-activating_peptide by dispersed adult porcine islet cells .
9169094	0	Insulin	0,7	glucose-6-phosphatase	48,69	Insulin	glucose-6-phosphatase	483665(Tax:9615)	403492(Tax:9615)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Insulin resistance and the transcription of the glucose-6-phosphatase gene in newborn dogs .
25091498	0	Insulin	0,7	glucose-dependent_insulinotropic_peptide	15,55	Insulin	glucose-dependent insulinotropic peptide	3630	2695	Gene	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|amod|END_ENTITY	Insulin drives glucose-dependent_insulinotropic_peptide expression via glucose-dependent regulation of FoxO1 and LEF1/b-catenin .
7705803	0	Insulin	0,7	glucose-dependent_insulinotropic_peptide	39,79	Insulin	glucose-dependent insulinotropic peptide	3630	2695	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Insulin secretion and plasma levels of glucose-dependent_insulinotropic_peptide and glucagon-like_peptide_1 -LSB- 7-36 amide -RSB- after oral glucose in cirrhosis .
10224108	0	Insulin	0,7	growth_hormone	17,31	Insulin	growth hormone	3630	2688	Gene	Gene	inhibits|compound|START_ENTITY END_ENTITY|nsubj|inhibits	Insulin inhibits growth_hormone signaling via the growth_hormone receptor/JAK2/STAT5B pathway .
10442567	0	Insulin	0,7	growth_hormone	23,37	Insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Insulin sensitivity in growth_hormone -LRB- GH -RRB- - deficient adults and effect of GH replacement therapy .
16439844	0	Insulin	0,7	growth_hormone	35,49	Insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|adults adults|nmod|deficiency deficiency|amod|END_ENTITY	Insulin sensitivity in adults with growth_hormone deficiency and effect of growth_hormone treatment .
16439844	0	Insulin	0,7	growth_hormone	75,89	Insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|treatment treatment|amod|END_ENTITY	Insulin sensitivity in adults with growth_hormone deficiency and effect of growth_hormone treatment .
2903152	0	Insulin	0,7	growth_hormone	42,56	Insulin	growth hormone	3630	2688	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Insulin regulates expression of the human growth_hormone gene in transfected cells .
360062	0	Insulin	0,7	growth_hormone	52,66	Insulin	growth hormone	3630	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Insulin binding and insulin sensitivity in isolated growth_hormone deficiency .
7042427	0	Insulin	0,7	growth_hormone	127,141	Insulin	growth hormone	3630	2688	Gene	Gene	absorption|compound|START_ENTITY absorption|dep|glucose glucose|appos|levels levels|compound|END_ENTITY	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise : blood glucose , plasma insulin , growth_hormone , adrenaline and noradrenaline levels .
719944	0	Insulin	1,8	growth_hormone	106,120	Insulin	growth hormone	3630	2688	Gene	Gene	therapy|compound|START_ENTITY antagonist|nsubj|therapy antagonist|nmod|reactions reactions|nmod|END_ENTITY	-LSB- Insulin therapy and behaviors of insulin antagonist hormones , with special reference to the reactions of growth_hormone and cortisol during the hypoglycemic stage in juvenile diabetes -RSB- .
8582710	0	Insulin	0,7	growth_hormone	32,46	Insulin	growth hormone	3630	2688	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Insulin antagonistic effects of growth_hormone in short children .
9326618	0	Insulin	0,7	growth_hormone	82,96	Insulin	growth hormone	3630	2688	Gene	Gene	factor-I|compound|START_ENTITY inhibit|nsubj|factor-I inhibit|dobj|translocation translocation|nmod|receptors receptors|amod|END_ENTITY	Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth_hormone receptors in osteoblasts : a novel mechanism of growth_hormone receptor regulation .
12032158	0	Insulin	0,7	hypoxia-inducible_factor_1	19,45	Insulin	hypoxia-inducible factor 1	3630	3091	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Insulin stimulates hypoxia-inducible_factor_1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway .
19996311	0	Insulin	0,7	hypoxia-inducible_factor_1	41,67	Insulin	hypoxia-inducible factor 1	3630	3091	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Insulin induces REDD1 expression through hypoxia-inducible_factor_1 activation in adipocytes .
16893359	0	Insulin	0,7	insulin	18,25	Insulin	insulin	3630	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|resistance resistance|compound|END_ENTITY	Insulin levels in insulin resistance : phantom of the metabolic opera ?
17429060	0	Insulin	96,103	insulin	47,54	Insulin	insulin	3630	3630	Gene	Gene	Resistance|amod|START_ENTITY END_ENTITY|dep|Resistance	Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort : the Insulin Resistance Atherosclerosis Study .
20425567	0	Insulin	0,7	insulin	9,16	Insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Insulin , insulin resistance , obesity , and cancer .
2055417	0	Insulin	0,7	insulin	62,69	Insulin	insulin	3630	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Insulin and C-peptide levels following oral administration of insulin in intestinal-enzyme protected capsules .
22444446	1	Insulin	100,107	insulin	148,155	Insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Insulin response with and without a long-acting insulin treatment .
3296383	0	Insulin	0,7	insulin	50,57	Insulin	insulin	3630	3630	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Insulin receptor binding and metabolic effects of insulin in human subcutaneous adipose tissue in untreated non-insulin_dependent_diabetes_mellitus .
3304396	0	Insulin	1,8	insulin	38,45	Insulin	insulin	3630	3630	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	-LSB- Insulin secretion and utilization of insulin in piglets after insulin , arginine and glucose loads -RSB- .
3308560	0	Insulin	0,7	insulin	73,80	Insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Insulin as a growth regulator of arterial smooth muscle cells : effect of insulin of I.G.F.I. .
8745203	0	Insulin	0,7	insulin	32,39	Insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Insulin versus a combination of insulin and sulfonylurea in the treatment of NIDDM patients with secondary oral failure .
967015	0	Insulin	0,7	insulin	77,84	Insulin	insulin	3630	3630	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Insulin sensitivity of adipose tissue in vitro and the response to exogenous insulin in obese human subjects .
9514933	0	Insulin	0,7	insulin-degrading_enzyme	52,76	Insulin	insulin-degrading enzyme	3630	3416	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Insulin acts intracellularly on proteasomes through insulin-degrading_enzyme .
1375600	0	Insulin	0,7	insulin-like_growth_factor_binding_protein-1	22,66	Insulin	insulin-like growth factor binding protein-1	3630	3484	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Insulin regulation of insulin-like_growth_factor_binding_protein-1 in obese and nonobese humans .
10902810	0	Insulin	0,7	intercellular_adhesion_molecule-1	35,68	Insulin	intercellular adhesion molecule-1	3630	3383	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Insulin inhibits the expression of intercellular_adhesion_molecule-1 by human_aortic_endothelial_cells through stimulation of nitric_oxide .
14532168	0	Insulin	0,7	interleukin-6	19,32	Insulin	interleukin-6	3630	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Insulin stimulates interleukin-6 and tumor_necrosis_factor-alpha gene expression in human subcutaneous adipose tissue .
18617614	0	Insulin	0,7	interleukin-6	19,32	Insulin	interleukin-6	3630	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes through multiple signaling pathways .
10353113	0	Insulin	1,8	leptin	104,110	Insulin	leptin	3630	3952	Gene	Gene	constitute|nsubj|START_ENTITY constitute|dobj|determinants determinants|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Insulin secretion in women and insulin_sensitivity in men constitute independent determinants of serum leptin concentration -RSB- .
10447517	0	Insulin	0,7	leptin	24,30	Insulin	leptin	3630	3952	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|concentrations concentrations|compound|END_ENTITY	Insulin increases serum leptin concentrations in children and adolescents with newly diagnosed type_I_diabetes_mellitus with and without ketoacidosis .
10833328	0	Insulin	0,7	leptin	18,24	Insulin	leptin	3630	3952	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans .
10875631	0	Insulin	0,7	leptin	22,28	Insulin	leptin	397415(Tax:9823)	396832(Tax:9823)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Insulin regulation of leptin expression in streptozotocin diabetic pigs .
10968481	0	Insulin	0,7	leptin	91,97	Insulin	leptin	3630	3952	Gene	Gene	determinants|nsubj|START_ENTITY determinants|nmod|variation variation|nmod|END_ENTITY	Insulin and insulin resistance index are not independent determinants for the variation in leptin in obese children and adolescents .
11387233	0	Insulin	0,7	leptin	52,58	Insulin	leptin	3630	3952	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes .
12935365	0	Insulin	0,7	leptin	20,26	Insulin	leptin	3630	3952	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Insulin resistance , leptin and TNF-alpha system in morbidly obese women after gastric bypass .
19267279	0	Insulin	0,7	leptin	20,26	Insulin	leptin	3630	3952	Gene	Gene	START_ENTITY|dobj|levels levels|compound|END_ENTITY	Insulin resistance , leptin and monocyte_chemotactic_protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects .
23718986	0	Insulin	0,7	leptin	17,23	Insulin	leptin	3630	3952	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Insulin enhances leptin expression in human trophoblastic cells .
8826983	0	Insulin	0,7	leptin	29,35	Insulin	leptin	3630	3952	Gene	Gene	promote|nsubj|START_ENTITY promote|dobj|production production|compound|END_ENTITY	Insulin and cortisol promote leptin production in cultured human fat cells .
8858224	0	Insulin	0,7	leptin	25,31	Insulin	leptin	3630	3952	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|concentrations concentrations|compound|END_ENTITY	Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM .
9690055	0	Insulin	0,7	leptin	66,72	Insulin	leptin	3630	3952	Gene	Gene	have|nsubj|START_ENTITY have|dobj|effect effect|nmod|levels levels|compound|END_ENTITY	Insulin and body fat distribution have no direct effect on plasma leptin levels in obese Caucasian women with and without type_2_diabetes_mellitus .
7683660	0	Insulin	0,7	nucleolin	39,48	Insulin	nucleolin	3630	4691	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Insulin induces the phosphorylation of nucleolin .
1989989	0	Insulin	0,7	ornithine_decarboxylase	21,44	Insulin	ornithine decarboxylase	3630	4953	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Insulin induction of ornithine_decarboxylase .
10560468	0	Insulin	0,7	pen	23,26	Insulin	pen	3630	340348	Gene	Gene	delivery|compound|START_ENTITY delivery|acl|using using|dobj|devices devices|compound|END_ENTITY	Insulin delivery using pen devices .
17954427	0	Insulin	0,7	pen	8,11	Insulin	pen	3630	340348	Gene	Gene	devices|amod|START_ENTITY devices|compound|END_ENTITY	Insulin pen injection devices for management of patients with type 2 diabetes : considerations based on an endocrinologist 's practical experience in the United States .
19075079	0	Insulin	0,7	pen	71,74	Insulin	pen	3630	340348	Gene	Gene	devices|compound|START_ENTITY devices|dep|addressing addressing|nmod|therapy therapy|nmod|END_ENTITY	Insulin devices : addressing barriers to insulin therapy with the ideal pen .
19885358	0	Insulin	0,7	pen	49,52	Insulin	pen	3630	340348	Gene	Gene	pen-the|nsubj|START_ENTITY pen-the|parataxis|wins wins|nsubj|END_ENTITY	Insulin pen-the `` iPod '' for insulin delivery -LRB- why pen wins over syringe -RRB- .
20515313	0	Insulin	0,7	pen	8,11	Insulin	pen	3630	340348	Gene	Gene	use|compound|START_ENTITY use|compound|END_ENTITY	Insulin pen use for type 2 diabetes -- a clinical perspective .
20615098	0	Insulin	0,7	pen	37,40	Insulin	pen	3630	340348	Gene	Gene	leakage|nsubj|START_ENTITY leakage|nmod|length length|compound|END_ENTITY	Insulin leakage value in relation to pen needle length and administered dose after subcutaneous injection .
23790553	0	Insulin	0,7	pen	8,11	Insulin	pen	3630	340348	Gene	Gene	needles|amod|START_ENTITY needles|compound|END_ENTITY	Insulin pen needles : effects of extra-thin wall needle technology on preference , confidence , and other patient ratings .
10102684	0	Insulin	0,7	peroxisome_proliferator-activated_receptor-gamma	48,96	Insulin	peroxisome proliferator-activated receptor-gamma	3630	5468	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Insulin acutely regulates the expression of the peroxisome_proliferator-activated_receptor-gamma in human adipocytes .
17095578	0	Insulin	0,7	phosphoenolpyruvate_carboxykinase	18,51	Insulin	phosphoenolpyruvate carboxykinase	3630	5106	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	Insulin represses phosphoenolpyruvate_carboxykinase gene transcription by causing the rapid disruption of an active transcription complex : a potential epigenetic effect .
2558935	0	Insulin	0,7	phosphoinositide-specific_phospholipase_C	28,69	Insulin	phosphoinositide-specific phospholipase C	3630	23236	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Insulin does not activate a phosphoinositide-specific_phospholipase_C in adipocytes .
3149048	0	Insulin	0,7	plasminogen_activator_inhibitor_1	36,69	Insulin	plasminogen activator inhibitor 1	3630	5054	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|nmod|END_ENTITY	Insulin stimulates the synthesis of plasminogen_activator_inhibitor_1 by the human hepatocellular cell line Hep G2 .
2656248	0	Insulin	0,7	prolactin	48,57	Insulin	prolactin	3630	5617	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|nmod|END_ENTITY	Insulin stimulates the synthesis and release of prolactin from human decidual cells .
20118282	0	Insulin	0,7	protease-activated_receptor_2	18,47	Insulin	protease-activated receptor 2	3630	14063(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|signaling signaling|amod|END_ENTITY	Insulin modulates protease-activated_receptor_2 signaling : implications for the innate immune response .
11444881	0	Insulin	0,7	resistin	58,66	Insulin	resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY related|nsubjpass|resistance related|xcomp|END_ENTITY	Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle .
12627322	0	Insulin	0,7	resistin	114,122	Insulin	resistin	3630	56729	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|nmod|synthesis synthesis|nmod|protein protein|acl:relcl|accelerate accelerate|dobj|degradation degradation|nmod|mRNA mRNA|compound|END_ENTITY	Insulin down-regulates resistin mRNA through the synthesis of protein -LRB- s -RRB- that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes .
12627322	0	Insulin	0,7	resistin	23,31	Insulin	resistin	3630	56729	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|mRNA mRNA|compound|END_ENTITY	Insulin down-regulates resistin mRNA through the synthesis of protein -LRB- s -RRB- that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes .
6105428	0	Insulin	0,7	secretin	20,28	Insulin	secretin	3630	6343	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Insulin response to secretin , a possible basis for diagnostic test of primary_hyperparathyroidism .
15646039	0	Insulin	0,7	stratifin	53,62	Insulin	stratifin	3630	2810	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|effect effect|nmod|END_ENTITY	Insulin suppresses collagenase stimulatory effect of stratifin in dermal fibroblasts .
11340211	0	Insulin	0,7	tissue_plasminogen_activator	42,70	Insulin	tissue plasminogen activator	3630	100128998	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Insulin resistance and elevated levels of tissue_plasminogen_activator in first-degree relatives of South Asian patients with ischemic cerebrovascular_disease .
10329259	0	Insulin	0,7	vascular_endothelial_growth_factor	108,142	Insulin	vascular endothelial growth factor	3630	7422	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Insulin stimulates the growth and tube formation of human microvascular endothelial cells through autocrine vascular_endothelial_growth_factor .
10777488	0	Insulin	0,7	vascular_endothelial_growth_factor	48,82	Insulin	vascular endothelial growth factor	3630	7422	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Insulin and insulin-like growth factor-I induce vascular_endothelial_growth_factor mRNA expression via different signaling pathways .
11232025	0	Insulin	0,7	vascular_endothelial_growth_factor	21,55	Insulin	vascular endothelial growth factor	3630	7422	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Insulin up-regulates vascular_endothelial_growth_factor and stabilizes its messengers in endometrial_adenocarcinoma cells .
14633819	0	Insulin	0,7	vascular_endothelial_growth_factor	43,77	Insulin	vascular endothelial growth factor	3630	7422	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|concentration concentration|nmod|metalloproteinase-9 metalloproteinase-9|compound|END_ENTITY	Insulin suppresses plasma concentration of vascular_endothelial_growth_factor and matrix metalloproteinase-9 .
15473891	0	Insulin	0,7	vascular_endothelial_growth_factor	18,52	Insulin	vascular endothelial growth factor	3630	83785(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Insulin activates vascular_endothelial_growth_factor in vascular smooth muscle cells : influence of nitric_oxide and of insulin resistance .
6255473	0	Insulin	0,7	vasopressin	55,66	Insulin	vasopressin	397415(Tax:9823)	396995(Tax:9823)	Gene	Gene	increase|nsubj|START_ENTITY increase|dobj|number number|nmod|receptors receptors|nmod|END_ENTITY	Insulin and serum increase the number of receptors for vasopressin in a kidney-derived line of cells grown in a defined medium .
3106082	0	Insulin	0,7	vinculin	69,77	Insulin	vinculin	3630	7414	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin but not phorbol_ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H-1 myocytes .
25398592	0	Insulin-Like_Growth_Factor-1	0,28	Cbx8	48,52	Insulin-Like Growth Factor-1	Cbx8	3479	57332	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Insulin-Like_Growth_Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon_Cancer Cell Apoptosis .
25765099	0	Insulin-Like_Growth_Factor-1	56,84	Growth_Hormone	18,32	Insulin-Like Growth Factor-1	Growth hormone	3479	2688	Gene	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Recombinant Human Growth_Hormone Plus Recombinant Human Insulin-Like_Growth_Factor-1 Coadministration Therapy in Short Children with Low Insulin-Like_Growth_Factor-1 and Growth_Hormone Sufficiency : Results from a Randomized , Multicenter , Open-Label , Parallel-Group , Active Treatment-Controlled Trial .
22303302	0	Insulin-Like_Growth_Factor_1	39,67	IGF-1	69,74	Insulin-Like Growth Factor 1	IGF-1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Single Nucleotide Polymorphisms in the Insulin-Like_Growth_Factor_1 -LRB- IGF-1 -RRB- Gene are Associated with Performance in Holstein-Friesian Dairy Cattle .
27038749	0	Insulin-Like_Growth_Factor_1	12,40	IGF-1	42,47	Insulin-Like Growth Factor 1	IGF-1	3479	3479	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of Insulin-Like_Growth_Factor_1 -LRB- IGF-1 -RRB- in brain development , maturation and neuroplasticity .
25520502	0	Insulin-Like_Growth_Factor_1	28,56	IGF1	58,62	Insulin-Like Growth Factor 1	IGF1	3479	3479	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
25520502	0	Insulin-Like_Growth_Factor_1	28,56	LMP1	0,4	Insulin-Like Growth Factor 1	LMP1	3479	9260	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
25601855	0	Insulin-Like_Growth_Factor_Binding_Protein-6	24,68	IGFBP-6	70,77	Insulin-Like Growth Factor Binding Protein-6	IGFBP-6	3489	3489	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Differential Effects of Insulin-Like_Growth_Factor_Binding_Protein-6 -LRB- IGFBP-6 -RRB- on Migration of Two Ovarian_Cancer Cell Lines .
26559475	0	Insulin-Like_Growth_Factor_Binding_Protein_2	12,56	IGFBP2	58,64	Insulin-Like Growth Factor Binding Protein 2	IGFBP2	3485	3485	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Insulin-Like_Growth_Factor_Binding_Protein_2 -LRB- IGFBP2 -RRB- in the Regulation of Corneal Fibroblast Differentiation .
25558444	0	Insulin-Regulated_Aminopeptidase	14,46	IRAP	48,52	Insulin-Regulated Aminopeptidase	IRAP	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of Insulin-Regulated_Aminopeptidase -LRB- IRAP -RRB- by Arylsulfonamides .
26553165	0	Insulin-like_Growth_Factor-1	21,49	IGF-1	51,56	Insulin-like Growth Factor-1	IGF-1	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Donepezil may reduce Insulin-like_Growth_Factor-1 -LRB- IGF-1 -RRB- levels in Alzheimer 's _ disease .
27089502	0	Insulin-like_Growth_Factor-1	42,70	IGF-1	72,77	Insulin-like Growth Factor-1	IGF-1	3479	3479	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Receptor-mediated Selective Impairment of Insulin-like_Growth_Factor-1 -LRB- IGF-1 -RRB- activity in Congenital_Disorders_of_Glycosylation Patients .
26265685	0	Insulin-like_Growth_Factor-1_Receptor	11,48	IGF1R	50,55	Insulin-like Growth Factor-1 Receptor	IGF1R	3480	3480	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Membranous Insulin-like_Growth_Factor-1_Receptor -LRB- IGF1R -RRB- Expression Is Predictive of Poor Prognosis in Patients with Epidermal_Growth_Factor_Receptor -LRB- <i> EGFR </i> -RRB- - Mutant Lung Adenocarcinoma .
26245897	0	Insulin-like_Growth_Factor-Binding_Protein_1	95,139	Macrophage_Colony_Stimulating_Factor	21,57	Insulin-like Growth Factor-Binding Protein 1	Macrophage Colony Stimulating Factor	3484	1435	Gene	Gene	Release|nmod|START_ENTITY Induces|dobj|Release Induces|nsubj|END_ENTITY	Glioblastoma-derived Macrophage_Colony_Stimulating_Factor -LRB- MCSF -RRB- Induces Microglial Release of Insulin-like_Growth_Factor-Binding_Protein_1 -LRB- IGFBP1 -RRB- to Promote Angiogenesis .
26245897	0	Insulin-like_Growth_Factor-Binding_Protein_1	95,139	Macrophage_Colony_Stimulating_Factor	21,57	Insulin-like Growth Factor-Binding Protein 1	Macrophage Colony Stimulating Factor	3484	1435	Gene	Gene	Release|nmod|START_ENTITY Induces|dobj|Release Induces|nsubj|END_ENTITY	Glioblastoma-derived Macrophage_Colony_Stimulating_Factor -LRB- MCSF -RRB- Induces Microglial Release of Insulin-like_Growth_Factor-Binding_Protein_1 -LRB- IGFBP1 -RRB- to Promote Angiogenesis .
26680853	0	Insulin-like_Growth_Factor-I	15,43	IGF-I	45,50	Insulin-like Growth Factor-I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	The Effects of Insulin-like_Growth_Factor-I -LRB- IGF-I -RRB- in Mouse Lung_Cancer Cells .
26743528	0	Insulin-like_Growth_Factor_1	0,28	ATP-Binding_Cassette_Transporter_A1	57,92	Insulin-like Growth Factor 1	ATP-Binding Cassette Transporter A1	24482(Tax:10116)	313210(Tax:10116)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|nmod|END_ENTITY	Insulin-like_Growth_Factor_1 Regulates the Expression of ATP-Binding_Cassette_Transporter_A1 in Pancreatic Beta Cells .
7949595	1	Insulin-like_Growth_Factor_I	126,154	Growth_Hormone	168,182	Insulin-like Growth Factor I	Growth Hormone	3479	2688	Gene	Gene	Treatment|compound|START_ENTITY Group|nmod|Treatment Group|nmod|Syndromes Syndromes|compound|END_ENTITY	Pharmacia Study Group on Insulin-like_Growth_Factor_I Treatment in Growth_Hormone Insensitivity Syndromes .
8722689	0	Insulin-like_growth_factor	0,26	IGF-I	28,33	Insulin-like growth factor	IGF-I	3479	3479	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Insulin-like_growth_factor -LRB- IGF-I -RRB- mRNA and IGF-I_receptor in trout testis and in isolated spermatogenic and Sertoli cells .
17308090	0	Insulin-like_growth_factor-1	0,28	CCN5	52,56	Insulin-like growth factor-1	CCN5	3479	8839	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- induces WISP-2 / CCN5 via multiple molecular cross-talks and is essential for mitogenic switch by IGF-1 axis in estrogen_receptor-positive breast_tumor cells .
23211593	0	Insulin-like_growth_factor-1	0,28	ERK1	67,71	Insulin-like growth factor-1	ERK1	3479	5595	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Insulin-like_growth_factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells .
20034543	0	Insulin-like_growth_factor-1	0,28	KiSS-1	57,63	Insulin-like growth factor-1	KiSS-1	24482(Tax:10116)	289023(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expression expression|compound|END_ENTITY	Insulin-like_growth_factor-1 stimulation of hypothalamic KiSS-1 gene expression is mediated by Akt : effect of alcohol .
23211593	0	Insulin-like_growth_factor-1	0,28	MUC8	37,41	Insulin-like growth factor-1	MUC8	3479	100129528	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Insulin-like_growth_factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells .
10027414	0	Insulin-like_growth_factor-1	0,28	Mdm2	37,41	Insulin-like growth factor-1	Mdm2	3479	4193	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Insulin-like_growth_factor-1 induces Mdm2 and down-regulates p53 , attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis .
22490886	0	Insulin-like_growth_factor-1	0,28	PRAS40	60,66	Insulin-like growth factor-1	PRAS40	24482(Tax:10116)	292887(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Insulin-like_growth_factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells .
15304489	0	Insulin-like_growth_factor-1	0,28	RUNX2	50,55	Insulin-like growth factor-1	RUNX2	3479	860	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Insulin-like_growth_factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol_3-kinase / ERK-dependent and Akt-independent signaling pathway .
14522909	0	Insulin-like_growth_factor-1	0,28	beta1-integrin	110,124	Insulin-like growth factor-1	beta1-integrin	3479	3688	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Insulin-like_growth_factor-1 induces adhesion and migration in human multiple_myeloma cells via activation of beta1-integrin and phosphatidylinositol_3 ' - kinase/AKT signaling .
12065326	0	Insulin-like_growth_factor-1	0,28	c-Jun	127,132	Insulin-like growth factor-1	c-Jun	3479	3725	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Insulin-like_growth_factor-1 enhances inflammatory responses in endothelial cells : role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression .
9591782	0	Insulin-like_growth_factor-1	0,28	prolactin	44,53	Insulin-like growth factor-1	prolactin	24482(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Insulin-like_growth_factor-1 stimulates rat prolactin gene expression by a Ras , ETS and phosphatidylinositol 3-kinase dependent mechanism .
21567071	0	Insulin-like_growth_factor-1	0,28	prostate_apoptosis_response-4	61,90	Insulin-like growth factor-1	prostate apoptosis response-4	3479	5074	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor-1 and 17b-estradiol down-regulate prostate_apoptosis_response-4 expression in MCF-7 breast_cancer cells .
26131572	0	Insulin-like_growth_factor-1_receptor	0,37	IGF-1R	39,45	Insulin-like growth factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibition promotes expansion of human NK cells which maintain their potent antitumor activity against Ewing_sarcoma cells .
22430216	0	Insulin-like_growth_factor-I	0,28	GPER	39,43	Insulin-like growth factor-I	GPER	3479	2852	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Insulin-like_growth_factor-I regulates GPER expression and function in cancer cells .
17116363	0	Insulin-like_growth_factor-I	0,28	IGF-I	30,35	Insulin-like growth factor-I	IGF-I	104978413	104978413	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- system during follicle development in the bovine ovary : relationship among IGF-I , type 1 IGF receptor -LRB- IGFR-1 -RRB- and pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- .
7684393	0	Insulin-like_growth_factor-I	0,28	IGF-binding_protein-1	60,81	Insulin-like growth factor-I	IGF-binding protein-1	3479	3484	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- inhibits production of IGF-binding_protein-1 while stimulating estradiol secretion in granulosa cells from normal and polycystic human ovaries .
7546777	0	Insulin-like_growth_factor-I	0,28	IGFBP-3	47,54	Insulin-like growth factor-I	IGFBP-3	3479	3486	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- regulates IGFBP-3 and IGFBP-4 by multiple mechanisms in A549 human adenocarcinoma cells .
18567639	0	Insulin-like_growth_factor-I	0,28	Nox4	99,103	Insulin-like growth factor-I	Nox4	24482(Tax:10116)	85431(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Insulin-like_growth_factor-I induces reactive_oxygen_species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells .
23709620	0	Insulin-like_growth_factor-I	0,28	Wnt5a	110,115	Insulin-like growth factor-I	Wnt5a	3479	7474	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Insulin-like_growth_factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a .
16642470	0	Insulin-like_growth_factor-I	0,28	bone_sialoprotein	39,56	Insulin-like growth factor-I	bone sialoprotein	3479	3381	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Insulin-like_growth_factor-I increases bone_sialoprotein -LRB- BSP -RRB- expression through fibroblast_growth_factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene .
24323236	0	Insulin-like_growth_factor-I	0,28	growth-hormone	38,52	Insulin-like growth factor-I	growth-hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Insulin-like_growth_factor-I and fast growth-hormone levels in mild and moderately malnourished children .
1658632	0	Insulin-like_growth_factor-I	0,28	growth_hormone	52,66	Insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	attenuation|amod|START_ENTITY attenuation|nmod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- attenuation of growth_hormone is enhanced by overexpression of pituitary IGF-I_receptors .
18521839	0	Insulin-like_growth_factor-I	0,28	growth_hormone	140,154	Insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|dep|distribution distribution|nmod|administration administration|amod|END_ENTITY	Insulin-like_growth_factor-I of pejerrey , Odontesthes bonariensis : cDNA characterization , tissue distribution and expression profiles after growth_hormone administration .
22562529	0	Insulin-like_growth_factor-I	0,28	growth_hormone	58,72	Insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	correlates|nsubj|START_ENTITY correlates|advmod|closely closely|nmod|END_ENTITY	Insulin-like_growth_factor-I correlates more closely than growth_hormone with insulin resistance and glucose_intolerance in patients with acromegaly .
8858219	0	Insulin-like_growth_factor-I	0,28	growth_hormone	91,105	Insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|mobilization mobilization|acl|induced induced|nmod|pulse pulse|amod|END_ENTITY	Insulin-like_growth_factor-I in man enhances lipid mobilization and oxidation induced by a growth_hormone pulse .
9078817	0	Insulin-like_growth_factor-I	0,28	growth_hormone	68,82	Insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	screening|amod|START_ENTITY screening|nmod|diagnosis diagnosis|nmod|_ _|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- screening for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency .
9390011	0	Insulin-like_growth_factor-I	0,28	growth_hormone	116,130	Insulin-like growth factor-I	growth hormone	24482(Tax:10116)	2688	Gene	Gene	RNAs|nsubj|START_ENTITY RNAs|nmod|injection injection|nmod|END_ENTITY	Insulin-like_growth_factor-I , actin , and myosin heavy chain messenger RNAs in skeletal muscle after an injection of growth_hormone in subjects over 60 years old .
16331609	0	Insulin-like_growth_factor-I	0,28	insulin-like_growth_factor_binding_protein-3	30,74	Insulin-like growth factor-I	insulin-like growth factor binding protein-3	3479	3486	Gene	Gene	START_ENTITY|appos|risk risk|amod|END_ENTITY	Insulin-like_growth_factor-I , insulin-like_growth_factor_binding_protein-3 and the risk of fibrocystic_breast_conditions among Chinese women .
15067513	0	Insulin-like_growth_factor-I	0,28	p21	39,42	Insulin-like growth factor-I	p21	24482(Tax:10116)	24525(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Insulin-like_growth_factor-I increases p21 expression and attenuates cisplatin-induced acute renal_injury in rats .
18420583	0	Insulin-like_growth_factor-I	0,28	p85	115,118	Insulin-like growth factor-I	p85	3479	5296	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Insulin-like_growth_factor-I stimulates Shc-dependent phosphatidylinositol_3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells .
8730136	0	Insulin-like_growth_factor-I	0,28	somatomedin_C	30,43	Insulin-like growth factor-I	somatomedin C	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- somatomedin_C -RRB- levels in chronic_fatigue_syndrome and fibromyalgia .
1880476	0	Insulin-like_growth_factor-I	0,28	transforming_growth_factor-beta	115,146	Insulin-like growth factor-I	transforming growth factor-beta	3479	7040	Gene	Gene	production|amod|START_ENTITY production|dep|regulation regulation|nmod|END_ENTITY	Insulin-like_growth_factor-I production and action in porcine thyroid follicular cells in monolayer : regulation by transforming_growth_factor-beta .
16713312	0	Insulin-like_growth_factor-I	0,28	vascular_endothelial_growth_factor	39,73	Insulin-like growth factor-I	vascular endothelial growth factor	3479	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Insulin-like_growth_factor-I regulates vascular_endothelial_growth_factor secretion by human oviductal epithelial cells and stromal fibroblasts .
7683739	0	Insulin-like_growth_factor-binding_protein-1	0,44	insulin	57,64	Insulin-like growth factor-binding protein-1	insulin	3484	3630	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Insulin-like_growth_factor-binding_protein-1 response to insulin during suppression of endogenous insulin secretion .
10998426	0	Insulin-like_growth_factor-binding_protein-3	0,44	Bax	69,72	Insulin-like growth factor-binding protein-3	Bax	3486	581	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Insulin-like_growth_factor-binding_protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast_cancer cells .
10514513	0	Insulin-like_growth_factor-binding_protein-3	0,44	fibrinogen	51,61	Insulin-like growth factor-binding protein-3	fibrinogen	3486	2244	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Insulin-like_growth_factor-binding_protein-3 binds fibrinogen and fibrin .
11940579	0	Insulin-like_growth_factor-binding_protein-3	0,44	phosphotyrosine_phosphatase	57,84	Insulin-like growth factor-binding protein-3	phosphotyrosine phosphatase	3486	995	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Insulin-like_growth_factor-binding_protein-3 activates a phosphotyrosine_phosphatase .
23543219	0	Insulin-like_growth_factor-binding_protein-7	0,44	IGFBP7	46,52	Insulin-like growth factor-binding protein-7	IGFBP7	3490	3490	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Insulin-like_growth_factor-binding_protein-7 -LRB- IGFBP7 -RRB- transcript : A-to-I editing events in normal and cancerous human keratinocytes .
23555857	0	Insulin-like_growth_factor_1	0,28	CFTR	72,76	Insulin-like growth factor 1	CFTR	3479	1080	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- enhances the protein expression of CFTR .
23619527	0	Insulin-like_growth_factor_1	0,28	IGF-1	30,35	Insulin-like growth factor 1	IGF-1	3479	3479	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar_disorder patients .
2557967	0	Insulin-like_growth_factor_1	0,28	IGF-1	30,35	Insulin-like growth factor 1	IGF-1	3479	3479	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- receptors in the human brain : quantitative autoradiographic localization .
23089282	0	Insulin-like_growth_factor_1	0,28	IGF1	30,34	Insulin-like growth factor 1	IGF1	3479	3479	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF1 -RRB- polymorphism is associated with Alzheimer 's _ disease in Han Chinese .
15772344	0	Insulin-like_growth_factor_1	0,28	extracellular_signal-regulated_kinase	38,75	Insulin-like growth factor 1	extracellular signal-regulated kinase	3479	5594	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Insulin-like_growth_factor_1 inhibits extracellular_signal-regulated_kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway .
9084006	0	Insulin-like_growth_factor_1	0,28	growth_hormone	61,75	Insulin-like growth factor 1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	has|nsubj|START_ENTITY has|advcl|has has|nsubj|END_ENTITY	Insulin-like_growth_factor_1 has beneficial effects , whereas growth_hormone has limited effects on postoperative protein metabolism , gut integrity , and splenic weight in rats with chronic mild liver_injury .
21406062	0	Insulin-like_growth_factor_1	0,28	methionine_adenosyltransferase_2A	39,72	Insulin-like growth factor 1	methionine adenosyltransferase 2A	3479	4144	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Insulin-like_growth_factor_1 activates methionine_adenosyltransferase_2A transcription by multiple pathways in human colon_cancer cells .
26486515	0	Insulin-like_growth_factor_1	0,28	prolactin	47,56	Insulin-like growth factor 1	prolactin	114433(Tax:7955)	791526(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- regulates prolactin , growth hormone , and IGF-1 receptor expression in the pituitary gland of the gilthead sea bream Sparus aurata .
21092510	0	Insulin-like_growth_factor_1	1,29	stem_cell_factor	54,70	Insulin-like growth factor 1	stem cell factor	24482(Tax:10116)	60427(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Insulin-like_growth_factor_1 regulates expression of stem_cell_factor through ERKMAPK signaling pathway in gastric smooth muscle cell -RSB- .
23497056	0	Insulin-like_growth_factor_1_and_2	0,34	IGF1	36,40	Insulin-like growth factor 1 and 2	IGF1	3481;3479	3479	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Insulin-like_growth_factor_1_and_2 -LRB- IGF1 , IGF2 -RRB- expression in human microglia : differential regulation by inflammatory mediators .
21936711	0	Insulin-like_growth_factor_1_receptor	0,37	IGF-1R	39,45	Insulin-like growth factor 1 receptor	IGF-1R	3480	3480	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- inhibitor : another arrow in the quiver - Will it hit the moving target ?
26475121	0	Insulin-like_growth_factor_1_receptor	0,37	IGF1R	39,44	Insulin-like growth factor 1 receptor	IGF1R	3480	3480	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification .
2118859	0	Insulin-like_growth_factor_I	0,28	IGF-I	30,35	Insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels in follicular fluid from human preovulatory follicles : correlation with serum IGF-I levels .
11245675	0	Insulin-like_growth_factor_I	0,28	IGF-I_receptor	129,143	Insulin-like growth factor I	IGF-I receptor	3479	3480	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- protects cells from apoptosis by Alzheimer 's V642I mutant amyloid_precursor_protein through IGF-I_receptor in an IGF-binding protein-sensitive manner .
11245675	0	Insulin-like_growth_factor_I	0,28	amyloid_precursor_protein	95,120	Insulin-like growth factor I	amyloid precursor protein	3479	351	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|nmod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- protects cells from apoptosis by Alzheimer 's V642I mutant amyloid_precursor_protein through IGF-I_receptor in an IGF-binding protein-sensitive manner .
9457064	0	Insulin-like_growth_factor_I	0,28	c-myc	42,47	Insulin-like growth factor I	c-myc	104978413	511077(Tax:9913)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Insulin-like_growth_factor_I induction of c-myc expression in bovine fibroblasts can be blocked by antecedent insulin_receptor activation .
10537147	0	Insulin-like_growth_factor_I	0,28	growth_hormone	78,92	Insulin-like growth factor I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|xcomp|END_ENTITY	Insulin-like_growth_factor_I is essential for postnatal growth in response to growth_hormone .
15583470	0	Insulin-like_growth_factor_I	0,28	growth_hormone	88,102	Insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|markers markers|nmod|deficiency deficiency|amod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein_3 as diagnostic markers of growth_hormone deficiency in infancy .
16039893	0	Insulin-like_growth_factor_I	0,28	growth_hormone	53,67	Insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- measurements in growth_hormone -LRB- GH -RRB- therapy of idiopathic_short_stature -LRB- ISS -RRB- .
3016022	0	Insulin-like_growth_factor_I	0,28	growth_hormone	39,53	Insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	Insulin-like_growth_factor_I regulates growth_hormone secretion and messenger ribonucleic_acid levels in human pituitary_tumor cells .
8282965	0	Insulin-like_growth_factor_I	0,28	growth_hormone	93,107	Insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	values|amod|START_ENTITY values|dep|relationship relationship|nmod|levels levels|compound|END_ENTITY	Insulin-like_growth_factor_I values in patients on maintenance hemodialysis : relationship to growth_hormone and albumin levels .
8664976	0	Insulin-like_growth_factor_I	0,28	growth_hormone	101,115	Insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	alters|nsubj|START_ENTITY alters|dobj|metabolism metabolism|dep|comparison comparison|nmod|END_ENTITY	Insulin-like_growth_factor_I alters peripheral thyroid hormone metabolism in humans : comparison with growth_hormone .
7903898	0	Insulin-like_growth_factor_I	0,28	growth_hormone_releasing_factor	75,106	Insulin-like growth factor I	growth hormone releasing factor	24482(Tax:10116)	29446(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Insulin-like_growth_factor_I modulates hypothalamic somatostatin through a growth_hormone_releasing_factor increased somatostatin release and messenger ribonucleic_acid levels .
10714634	0	Insulin-like_growth_factor_I	0,28	insulin-like_growth_factor_binding_protein_3	49,93	Insulin-like growth factor I	insulin-like growth factor binding protein 3	24482(Tax:10116)	24484(Tax:10116)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Insulin-like_growth_factor_I in combination with insulin-like_growth_factor_binding_protein_3 affects the hepatic acute phase response and hepatic morphology in thermally injured rats .
10207105	0	Insulin-like_growth_factor_I	0,28	interleukin_4	45,58	Insulin-like growth factor I	interleukin 4	3479	3565	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Insulin-like_growth_factor_I synergizes with interleukin_4 for hematopoietic cell proliferation independent of insulin receptor substrate expression .
2973977	0	Insulin-like_growth_factor_I	0,28	prolactin	69,78	Insulin-like growth factor I	prolactin	3479	5617	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|nmod|END_ENTITY	Insulin-like_growth_factor_I stimulates the synthesis and release of prolactin from human decidual cells .
3652657	0	Insulin-like_growth_factor_I	0,28	tropoelastin	70,82	Insulin-like growth factor I	tropoelastin	100327329(Tax:9031)	396441(Tax:9031)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Insulin-like_growth_factor_I , somatomedin_C , induces the synthesis of tropoelastin in aortic tissue .
17316097	0	Insulin-like_growth_factor_binding_protein-1	0,44	insulin	59,66	Insulin-like growth factor binding protein-1	insulin	3484	3630	Gene	Gene	START_ENTITY|xcomp|screen screen|nmod|resistance resistance|compound|END_ENTITY	Insulin-like_growth_factor_binding_protein-1 to screen for insulin resistance in children .
27044294	0	Insulin-like_growth_factor_binding_protein-2	0,44	b-catenin	55,64	Insulin-like growth factor binding protein-2	b-catenin	3485	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Insulin-like_growth_factor_binding_protein-2 regulates b-catenin signaling pathway in glioma cells and together contributes to poor patient prognosis .
8726240	0	Insulin-like_growth_factor_binding_protein-3	0,44	growth_hormone	69,83	Insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	generation|amod|START_ENTITY generation|dep|index index|nmod|insensitivity insensitivity|amod|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 generation : an index of growth_hormone insensitivity .
22494072	0	Insulin-like_growth_factor_binding_protein-3	0,44	vascular_endothelial_growth_factor	56,90	Insulin-like growth factor binding protein-3	vascular endothelial growth factor	16009(Tax:10090)	22339(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 suppresses vascular_endothelial_growth_factor expression and tumor angiogenesis in head_and_neck_squamous_cell_carcinoma .
23770368	0	Insulin-like_growth_factor_binding_protein-3	0,44	vitamin_D_receptor	103,121	Insulin-like growth factor binding protein-3	vitamin D receptor	3486	7421	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 modulates osteoblast differentiation via interaction with vitamin_D_receptor .
16103088	0	Insulin-like_growth_factor_binding_protein-5	0,44	matrix_metalloproteinase-7	60,86	Insulin-like growth factor binding protein-5	matrix metalloproteinase-7	3488	4316	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Insulin-like_growth_factor_binding_protein-5 is a target of matrix_metalloproteinase-7 : implications for epithelial-mesenchymal signaling .
17595320	0	Insulin-like_growth_factor_binding_protein-5	0,44	vitamin_D_receptor	64,82	Insulin-like growth factor binding protein-5	vitamin D receptor	3488	7421	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Insulin-like_growth_factor_binding_protein-5 interacts with the vitamin_D_receptor and modulates the vitamin_D response in osteoblasts .
20188166	0	Insulin-like_growth_factor_binding_protein-6	0,44	Ku80	94,98	Insulin-like growth factor binding protein-6	Ku80	3489	7520	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Insulin-like_growth_factor_binding_protein-6 -LRB- IGFBP-6 -RRB- interacts with DNA-end binding protein Ku80 to regulate cell fate .
1280613	0	Insulin-like_growth_factor_binding_protein_1	0,44	IGFBP-1	46,53	Insulin-like growth factor binding protein 1	IGFBP-1	3484	3484	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Insulin-like_growth_factor_binding_protein_1 -LRB- IGFBP-1 -RRB- levels in Turner_syndrome .
7523002	0	Insulin-like_growth_factor_binding_protein_1	0,44	insulin	63,70	Insulin-like growth factor binding protein 1	insulin	3484	3630	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Insulin-like_growth_factor_binding_protein_1 response to acute insulin induced hypoglycaemia in type 1 diabetes .
19767315	0	Insulin-like_growth_factor_receptor_1	0,37	IGF1R	39,44	Insulin-like growth factor receptor 1	IGF1R	3480	3480	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Insulin-like_growth_factor_receptor_1 -LRB- IGF1R -RRB- expression and survival in surgically resected non-small-cell_lung_cancer -LRB- NSCLC -RRB- patients .
25101056	0	Insulin_Receptor	31,47	Insulin	59,66	Insulin Receptor	Insulin	100066248(Tax:9796)	100060077(Tax:9796)	Gene	Gene	Binding|compound|START_ENTITY Binding|compound|END_ENTITY	Estradiol Binds to Insulin and Insulin_Receptor Decreasing Insulin Binding in vitro .
25516545	0	Insulin_Receptor	87,103	Pre-B_Cell_Colony_Enhancing_Factor	0,34	Insulin Receptor	Pre-B Cell Colony Enhancing Factor	3643	10135	Gene	Gene	Translocation|nmod|START_ENTITY Induces|dobj|Translocation Induces|nsubj|END_ENTITY	Pre-B_Cell_Colony_Enhancing_Factor -LRB- PBEF -RRB- Induces Nampt-Dependent Translocation of the Insulin_Receptor Out of Lipid Microdomains in A549 Lung Epithelial Cells .
11725000	0	Insulin_Receptor	31,47	Protein_Kinase	0,14	Insulin Receptor	Protein Kinase	3643	1022	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Protein_Kinase Activity of the Insulin_Receptor Is Essential for Insulin-Regulated Gene Expression .
23381670	0	Insulin_Receptor_Substrate_1	46,74	PP2A	27,31	Insulin Receptor Substrate 1	PP2A	3667	5524	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Phosphoprotein_Phosphatase PP2A Regulation of Insulin_Receptor_Substrate_1 and Insulin Metabolic Signaling .
23381670	0	Insulin_Receptor_Substrate_1	46,74	Phosphoprotein_Phosphatase	0,26	Insulin Receptor Substrate 1	Phosphoprotein Phosphatase	3667	5504	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Phosphoprotein_Phosphatase PP2A Regulation of Insulin_Receptor_Substrate_1 and Insulin Metabolic Signaling .
11681709	0	Insulin_like_growth_factor-1	0,28	matrix_metalloproteinase-2	69,95	Insulin like growth factor-1	matrix metalloproteinase-2	3479	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Insulin_like_growth_factor-1 selectively regulates the expression of matrix_metalloproteinase-2 in malignant H-ras transformed cells .
24380854	0	Insulin_like_growth_factor_2	0,28	aryl_hydrocarbon_receptor	43,68	Insulin like growth factor 2	aryl hydrocarbon receptor	3481	196	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Insulin_like_growth_factor_2 regulation of aryl_hydrocarbon_receptor in MCF-7 breast_cancer cells .
25887188	0	Insulin_like_growth_factor_binding_protein_7	0,44	IGFBP7	46,52	Insulin like growth factor binding protein 7	IGFBP7	3490	3490	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Insulin_like_growth_factor_binding_protein_7 -LRB- IGFBP7 -RRB- expression is linked to poor prognosis but may protect from bone_disease in multiple_myeloma .
25887188	0	Insulin_like_growth_factor_binding_protein_7	0,44	IGFBP7	46,52	Insulin like growth factor binding protein 7	IGFBP7	3490	3490	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Insulin_like_growth_factor_binding_protein_7 -LRB- IGFBP7 -RRB- expression is linked to poor prognosis but may protect from bone_disease in multiple_myeloma .
21518241	0	Insulin_receptor	0,16	FOXO	68,72	Insulin receptor	FOXO	42549(Tax:7227)	41709(Tax:7227)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Insulin_receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan .
19211682	0	Insulin_receptor	15,31	Foxo	32,36	Insulin receptor	Foxo	42549(Tax:7227)	41709(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Integration of Insulin_receptor / Foxo signaling and dMyc activity during muscle growth regulates body size in Drosophila .
10229198	0	Insulin_receptor	0,16	IGF-II	31,37	Insulin receptor	IGF-II	3643	3481	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Insulin_receptor activation by IGF-II in breast_cancers : evidence for a new autocrine/paracrine mechanism .
8902843	0	Insulin_receptor	0,16	IRS-1	85,90	Insulin receptor	IRS-1	3643	3667	Gene	Gene	START_ENTITY|nmod|formation formation|nmod|complex complex|nmod|END_ENTITY	Insulin_receptor structural requirements for the formation of a ternary complex with IRS-1 and PI 3-kinase .
11514062	0	Insulin_receptor	0,16	p53	35,38	Insulin receptor	p53	24954(Tax:10116)	301300(Tax:10116)	Gene	Gene	localization|amod|START_ENTITY localization|compound|END_ENTITY	Insulin_receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine_neurodegeneration .
26972481	0	Insulin_receptor	0,16	sulfakinin	47,57	Insulin receptor	sulfakinin	661524(Tax:7070)	103313277	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Insulin_receptor regulates food intake through sulfakinin signaling in the red_flour_beetle , Tribolium_castaneum .
17902048	0	Insulin_receptor_substrate-1	0,28	epidermal_growth_factor_receptor	44,76	Insulin receptor substrate-1	epidermal growth factor receptor	3667	1956	Gene	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Insulin_receptor_substrate-1 involvement in epidermal_growth_factor_receptor and insulin-like growth factor receptor signalling : implication for Gefitinib -LRB- ` Iressa ' -RRB- response and resistance .
20226764	0	Insulin_receptor_substrate-3	0,28	p50	63,66	Insulin receptor substrate-3	p50	442338	4790	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Insulin_receptor_substrate-3 , interacting with Bcl-3 , enhances p50 NF-kappaB activity .
15255944	0	Insulin_receptor_substrate_of_53_kDa	0,36	PSD-95	65,71	Insulin receptor substrate of 53 kDa	PSD-95	10458	1742	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	Insulin_receptor_substrate_of_53_kDa links postsynaptic shank to PSD-95 .
3805277	0	Insulinlike_growth_factor_I	0,27	growth_hormone	42,56	Insulinlike growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Insulinlike_growth_factor_I regulation of growth_hormone gene transcription in primary rat pituitary cells .
11590142	0	Int-6	41,46	HSPC021	18,25	Int-6	HSPC021	3646	51386	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic_translation_initiation_factor_3 .
16171792	0	Int6	111,115	CYP21B	119,125	Int6	CYP21B	3646	1589	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Linkage between I172N mutation , a marker_of_21-hydroxylase_deficiency , and a single nucleotide polymorphism in Int6 of CYP21B gene : a genetic study of Sardinian family .
20016281	0	Int6	0,4	Cdc48	28,33	Int6	Cdc48	3646	851431(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation .
17324924	0	Int6	27,31	hypoxia_inducible_factor_2_alpha	53,85	Int6	hypoxia inducible factor 2 alpha	3646	2034	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Mammalian tumor suppressor Int6 specifically targets hypoxia_inducible_factor_2_alpha for degradation by hypoxia - and pVHL-independent regulation .
10891456	0	Integrin-associated_protein	0,27	CD47	28,32	Integrin-associated protein	CD47	961	961	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Integrin-associated_protein / CD47 regulates motile activity in human B-cell lines through CDC42 .
14563713	0	Integrin-associated_protein	0,27	thrombospondin-1	46,62	Integrin-associated protein	thrombospondin-1	961	7057	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Integrin-associated_protein binding domain of thrombospondin-1 enhances insulin-like_growth_factor-I receptor signaling in vascular smooth muscle cells .
18773488	0	Integrin-linked_kinase	0,22	E-cadherin	33,43	Integrin-linked kinase	E-cadherin	3611	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Integrin-linked_kinase regulates E-cadherin expression through PARP-1 .
19439446	0	Integrin-linked_kinase	0,22	ELMO2	41,46	Integrin-linked kinase	ELMO2	3611	63916	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Integrin-linked_kinase interactions with ELMO2 modulate cell polarity .
15105053	0	Integrin-linked_kinase	0,22	ILK	24,27	Integrin-linked kinase	ILK	3611	3611	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Integrin-linked_kinase -LRB- ILK -RRB- regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398 .
22814720	0	Integrin-linked_kinase	0,22	ILK	24,27	Integrin-linked kinase	ILK	3611	3611	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Integrin-linked_kinase -LRB- ILK -RRB- expression correlates with tumor severity in clear_cell_renal_carcinoma .
16474180	0	Integrin-linked_kinase	0,22	MMP-2	55,60	Integrin-linked kinase	MMP-2	3611	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Integrin-linked_kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells .
17526737	0	Integrin-linked_kinase	0,22	Notch1	32,38	Integrin-linked kinase	Notch1	3611	4851	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Integrin-linked_kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase .
18773488	0	Integrin-linked_kinase	0,22	PARP-1	63,69	Integrin-linked kinase	PARP-1	3611	142	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Integrin-linked_kinase regulates E-cadherin expression through PARP-1 .
21150927	0	Integrin-linked_kinase	0,22	TGF-b1	39,45	Integrin-linked kinase	TGF-b1	3611	7040	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	Integrin-linked_kinase is required for TGF-b1 induction of dermal myofibroblast differentiation .
11724787	0	Integrin-linked_kinase	0,22	inducible_nitric_oxide_synthase	33,64	Integrin-linked kinase	inducible nitric oxide synthase	16202(Tax:10090)	18126(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Integrin-linked_kinase regulates inducible_nitric_oxide_synthase and cyclooxygenase-2 expression in an NF-kappa_B-dependent manner .
21719054	0	Integrin-linked_kinase	0,22	phosphatase_and_tensin_homologue	33,65	Integrin-linked kinase	phosphatase and tensin homologue	3611	5728	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Integrin-linked_kinase regulates phosphatase_and_tensin_homologue activity to promote tumorigenesis in neuroblastoma cells .
24147211	0	Integrin_Alpha_4	76,92	Vascular_Cell_Adhesion_Molecule_1	31,64	Integrin Alpha 4	Vascular Cell Adhesion Molecule 1	16401(Tax:10090)	22329(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	Amino_Acid Sequences Mediating Vascular_Cell_Adhesion_Molecule_1 Binding to Integrin_Alpha_4 : Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein .
20631908	0	Integrin_alpha6	50,65	Thrombospondin-1	0,16	Integrin alpha6	Thrombospondin-1	3655	7057	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dep|Expression	Thrombospondin-1 -LRB- TSP-1 -RRB- Stimulates Expression of Integrin_alpha6 in Human Breast_Carcinoma Cells : A Downstream Modulator of TSP-1-Induced Cellular Adhesion .
17600088	0	Integrin_alpha_11	0,17	IGF2	28,32	Integrin alpha 11	IGF2	22801	3481	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Integrin_alpha_11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell_lung_cancer cells .
20651226	0	Integrin_alpha_7	0,16	high_temperature_requirement_A2	32,63	Integrin alpha 7	high temperature requirement A2	3679	27429	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Integrin_alpha_7 interacts with high_temperature_requirement_A2 -LRB- HtrA2 -RRB- to induce prostate_cancer cell death .
19334037	0	Integrin_alphavbeta3	0,20	integrin-linked_kinase	33,55	Integrin alphavbeta3	integrin-linked kinase	3685	3611	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Integrin_alphavbeta3 upregulates integrin-linked_kinase expression in human ovarian_cancer cells via enhancement of ILK gene transcription .
11919189	0	Integrin_cytoplasmic_domain-associated_protein_1alpha	0,53	nm23-H2	119,126	Integrin cytoplasmic domain-associated protein 1alpha	nm23-H2	9270	4831	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Integrin_cytoplasmic_domain-associated_protein_1alpha -LRB- ICAP-1alpha -RRB- interacts directly with the metastasis suppressor nm23-H2 , and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement .
18226209	0	Inter-alpha-trypsin_inhibitor_heavy_chain	28,69	ITIH	71,75	Inter-alpha-trypsin inhibitor heavy chain	ITIH	3697	3697	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Frequent expression loss of Inter-alpha-trypsin_inhibitor_heavy_chain -LRB- ITIH -RRB- genes in multiple human solid_tumors : a systematic expression analysis .
12920129	0	Interaction_protein_for_cytohesin_exchange_factors_1	0,52	cytohesin_2	68,79	Interaction protein for cytohesin exchange factors 1	cytohesin 2	26034	9266	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Interaction_protein_for_cytohesin_exchange_factors_1 -LRB- IPCEF1 -RRB- binds cytohesin_2 and modifies its activity .
26897511	0	Intercellular_Adhesion_Molecule_1	32,65	ICAM-1	67,73	Intercellular Adhesion Molecule 1	ICAM-1	3383	3383	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of Polymorphisms in Intercellular_Adhesion_Molecule_1 -LRB- ICAM-1 -RRB- Gene with Cancer Susceptibility : A Meta-Analysis of 14 Case-Control Studies .
12027924	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- polymorphism is associated with diabetic_retinopathy in Type_2_diabetes_mellitus .
12783117	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is upregulated by thrombin in human monocytes and THP-1 cells in vitro and in pregnant subjects in vivo .
1351874	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by lymph node dendritic cells : comparison with epidermal Langerhans cells .
17990298	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy .
1968316	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is upregulated in autoimmune murine lupus_nephritis .
20422421	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphism and endometriosis in northern Iran .
23364881	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression correlates with oral_cancer progression and induces macrophage/cancer cell adhesion .
8938544	0	Intercellular_adhesion_molecule-1	0,33	ICAM-1	35,41	Intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 ; CD54 -RRB- expression in human hepatocytic cells depends on protein kinase C. BACKGROUND/AIMS : Intracellular regulation of intercellular_adhesion_molecule-1 has mainly been studied in lymphoid , endothelial , and epithelial cells .
7906962	0	Intercellular_adhesion_molecule-1	0,33	MIP-1_alpha	78,89	Intercellular adhesion molecule-1	MIP-1 alpha	3383	6348	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Intercellular_adhesion_molecule-1 mediates the expression of monocyte-derived MIP-1_alpha during monocyte-endothelial cell interactions .
10077630	0	Intercellular_adhesion_molecule-1	0,33	interleukin_4	43,56	Intercellular adhesion molecule-1	interleukin 4	15894(Tax:10090)	16189(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Intercellular_adhesion_molecule-1 inhibits interleukin_4 production by naive T cells .
14621802	0	Intercellular_adhesion_molecule_1	0,33	ICAM-1	35,41	Intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- induction on hepatocytes is an early marker of acute liver allograft rejection .
15682683	0	Intercellular_adhesion_molecule_1	0,33	ICAM-1	35,41	Intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene variant is associated with coronary_artery_calcification independent of soluble ICAM-1 levels .
24022011	0	Intercellular_adhesion_molecule_1	0,33	Th1	56,59	Intercellular adhesion molecule 1	Th1	3383	51497	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|migration migration|nmod|cells cells|amod|END_ENTITY	Intercellular_adhesion_molecule_1 mediates migration of Th1 and Th17 cells across human retinal_vascular_endothelium .
25973438	0	Interferon-Gamma	22,38	CD8	53,56	Interferon-Gamma	CD8	3458	925	Gene	Gene	Expression|compound|START_ENTITY Control|nmod|Expression Control|nmod|Cells Cells|compound|END_ENTITY	Epigenetic Control of Interferon-Gamma Expression in CD8 T Cells .
25822580	0	Interferon-Gamma	0,16	TLR3	26,30	Interferon-Gamma	TLR3	3458	7098	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Interferon-Gamma Enhances TLR3 Expression and Anti-Viral Activity in Keratinocytes .
25816333	0	Interferon-Induced_Protein_with_Tetratricopeptide_Repeats_5	46,105	IFIT5	107,112	Interferon-Induced Protein with Tetratricopeptide Repeats 5	IFIT5	101797569	101797569	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Identification and Expression Analysis of the Interferon-Induced_Protein_with_Tetratricopeptide_Repeats_5 -LRB- IFIT5 -RRB- Gene in Duck -LRB- Anas_platyrhynchos domesticus -RRB- .
26600183	0	Interferon-a	52,64	Insulin	0,7	Interferon-a	Insulin	3440	3630	Gene	Gene	Response|nmod|START_ENTITY Response|compound|END_ENTITY	Insulin Resistance Predicts Virological Response to Interferon-a in Chronic Hepatitis_B Patients .
7577656	0	Interferon-alpha	0,16	granulocyte-macrophage_colony-stimulating_factor	38,86	Interferon-alpha	granulocyte-macrophage colony-stimulating factor	111654(Tax:10090)	12981(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Interferon-alpha -LRB- IFN-alpha -RRB- inhibits granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- expression at the post-transcriptional level in murine bone marrow stromal cells .
12101078	0	Interferon-alpha	0,16	leptin	28,34	Interferon-alpha	leptin	111654(Tax:10090)	3952	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Interferon-alpha suppresses leptin levels : studies in interferon-alpha treated patients with hepatitis_C virus infection and murine adipocytes .
1289407	0	Interferon-alpha/beta	0,21	interferon-gamma	67,83	Interferon-alpha/beta	interferon-gamma	15974(Tax:10090)	15978(Tax:10090)	Gene	Gene	synergize|nsubj|START_ENTITY synergize|nmod|END_ENTITY	Interferon-alpha/beta , pentoxifylline , and caffeine synergize with interferon-gamma to induce major histocompatibility complex class I expression on a constitutively class I-negative murine tumor cell line .
11755467	0	Interferon-alpha_2b	0,19	tumor_necrosis_factor-alpha	56,83	Interferon-alpha 2b	tumor necrosis factor-alpha	3440	7124	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Interferon-alpha_2b and vesnarinone influence levels of tumor_necrosis_factor-alpha , apoptosis , or interleukin_6 in ESKOL , a hairy cell leukemic cell line .
3171244	0	Interferon-beta_2	0,17	BSF-2	19,24	Interferon-beta 2	BSF-2	3569	3569	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Interferon-beta_2 -LRB- BSF-2 -RRB- mRNA is expressed in human monocytes .
8641346	0	Interferon-gamma	0,16	AP-1	72,76	Interferon-gamma	AP-1	3458	2353	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Interferon-gamma modulates the lipopolysaccharide-induced expression of AP-1 and NF-kappa_B at the mRNA and protein level in human monocytes .
3097125	0	Interferon-gamma	0,16	BSF-1	55,60	Interferon-gamma	BSF-1	3458	3565	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Interferon-gamma suppresses B cell stimulation factor -LRB- BSF-1 -RRB- induction of class II MHC determinants on B cells .
1375107	0	Interferon-gamma	0,16	CD34	74,78	Interferon-gamma	CD34	3458	947	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|proliferation proliferation|nmod|hematopoietic_progenitor_cells hematopoietic_progenitor_cells|compound|END_ENTITY	Interferon-gamma enhances factor-dependent myeloid proliferation of human CD34 + hematopoietic_progenitor_cells .
18511701	0	Interferon-gamma	0,16	CD4	65,68	Interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY +|ccomp|regulates +|nsubj|END_ENTITY	Interferon-gamma regulates idiopathic_pneumonia_syndrome , a Th17 + CD4 + T-cell-mediated graft-versus-host_disease .
10529600	0	Interferon-gamma	0,16	CD62L	27,32	Interferon-gamma	CD62L	3458	6402	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Interferon-gamma increases CD62L expression on human eosinophils .
10444028	0	Interferon-gamma	0,16	CD8	56,59	Interferon-gamma	CD8	3458	925	Gene	Gene	preferentially|amod|START_ENTITY reduces|nsubj|preferentially reduces|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Interferon-gamma preferentially reduces memory/effector CD8 T lymphocytes in healthy subjects .
11703361	0	Interferon-gamma	0,16	CD8	47,50	Interferon-gamma	CD8	3458	925	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|T T|compound|END_ENTITY	Interferon-gamma secretion of peripheral blood CD8 + T lymphocytes in patients with bronchial_asthma : in vitro stimulus determines cytokine production .
12536237	0	Interferon-gamma	0,16	CD8	67,70	Interferon-gamma	CD8	3458	925	Gene	Gene	secretion|amod|START_ENTITY impaired|nsubjpass|secretion impaired|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Interferon-gamma secretion and perforin expression are impaired in CD8 + T lymphocytes from patients with undifferentiated_carcinoma of nasopharyngeal type .
15958073	0	Interferon-gamma	0,16	CD8	32,35	Interferon-gamma	CD8	3458	925	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|cells cells|compound|END_ENTITY	Interferon-gamma is produced by CD8 T cells in response to HLA-A24-restricted hepatitis_C_virus epitopes after sustained virus loss .
25721262	0	Interferon-gamma	0,16	CD8	96,99	Interferon-gamma	CD8	3458	925	Gene	Gene	Melanogenesis|amod|START_ENTITY Melanogenesis|dep|Role Role|nmod|Lymphocytes Lymphocytes|compound|END_ENTITY	Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes : A Pivotal Role of CD8 + Cytotoxic T Lymphocytes in Vitiligo .
12368221	0	Interferon-gamma	0,16	CD95	26,30	Interferon-gamma	CD95	3458	355	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|END_ENTITY	Interferon-gamma augments CD95 -LRB- APO-1 / Fas -RRB- and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95-mediated apoptosis .
7526699	0	Interferon-gamma	0,16	CFTR	31,35	Interferon-gamma	CFTR	3458	1080	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Interferon-gamma downregulates CFTR gene expression in epithelial cells .
9612303	0	Interferon-gamma	0,16	Clara_cell_secretory_protein	34,62	Interferon-gamma	Clara cell secretory protein	3458	7356	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Interferon-gamma stimulates human Clara_cell_secretory_protein production by human airway epithelial cells .
7684703	0	Interferon-gamma	0,16	G-CSF	42,47	Interferon-gamma	G-CSF	3458	1440	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Interferon-gamma enhances the LPS-induced G-CSF gene expression in human adherent monocytes , which is regulated at transcriptional and posttranscriptional levels .
12700631	0	Interferon-gamma	0,16	Hsp27	31,36	Interferon-gamma	Hsp27	3458	3315	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Interferon-gamma downregulates Hsp27 expression and suppresses the negative regulation of cell death in oral_squamous_cell_carcinoma lines .
10573217	0	Interferon-gamma	0,16	ICAM-1	59,65	Interferon-gamma	ICAM-1	3458	3383	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Interferon-gamma and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts .
7905278	0	Interferon-gamma	0,16	ICAM-1	149,155	Interferon-gamma	ICAM-1	3458	3383	Gene	Gene	increases|amod|START_ENTITY increases|dep|concentration concentration|dep|relation relation|nmod|expression expression|compound|END_ENTITY	Interferon-gamma increases cellular calcium ion concentration and inositol_1 ,4,5 - trisphosphate formation in human renal_carcinoma cells : relation to ICAM-1 antigen expression .
8645468	0	Interferon-gamma	0,16	ICAM-1	110,116	Interferon-gamma	ICAM-1	3458	3383	Gene	Gene	increases|amod|START_ENTITY inositol_phosphate|nsubj|increases inositol_phosphate|xcomp|independent independent|nmod|enhancement enhancement|compound|END_ENTITY	Interferon-gamma increases inositol_phosphate formation and cellular calcium ion concentration independent of ICAM-1 antigen enhancement in renal tubular cells .
9409637	0	Interferon-gamma	0,16	ICAM-1	116,122	Interferon-gamma	ICAM-1	3458	3383	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- down-regulates the rhinovirus-induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on human airway epithelial cells .
11164459	0	Interferon-gamma	0,16	IFN-gamma	18,27	Interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- levels finally become stable with increasing age as revealed by using an ELISA corresponding to the bioactivity .
3125740	0	Interferon-gamma	0,16	IFN-gamma	18,27	Interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Interferon-gamma -LRB- IFN-gamma -RRB- as in vitro enhancing factor of peritoneal macrophage defective bactericidal activity during continuous_ambulatory_peritoneal_dialysis -LRB- CAPD -RRB- .
10673399	0	Interferon-gamma	0,16	IL-18_binding_protein	45,66	Interferon-gamma	IL-18 binding protein	3458	10068	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Interferon-gamma mediates gene expression of IL-18_binding_protein in nonleukocytic cells .
2518658	0	Interferon-gamma	0,16	IL-5	105,109	Interferon-gamma	IL-5	15978(Tax:10090)	16191(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Interferon-gamma inhibits the proliferation but not the differentiation of murine B cells in response to IL-5 .
11205286	0	Interferon-gamma	0,16	IL-6	27,31	Interferon-gamma	IL-6	3458	3569	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Interferon-gamma increases IL-6 production in human glioblastoma cell lines .
8383024	0	Interferon-gamma	0,16	IL-6	62,66	Interferon-gamma	IL-6	25712(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Interferon-gamma stimulates the secretion of IL-1 , but not of IL-6 , by glomerular mesangial cells .
8954078	0	Interferon-gamma	0,16	Ice	25,28	Interferon-gamma	Ice	3458	834	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interferon-gamma induces Ice gene expression and enhances cellular susceptibility to apoptosis in the U937 leukemia cell line .
7921639	0	Interferon-gamma	0,16	MHC	39,42	Interferon-gamma	MHC	3458	3133	Gene	Gene	expression|amod|START_ENTITY expression|nmod|antigens antigens|compound|END_ENTITY	Interferon-gamma induced expression of MHC antigens facilitates identification of donor cells in chimeric transplant recipients .
9521058	0	Interferon-gamma	0,16	PTX3	59,63	Interferon-gamma	PTX3	3458	5806	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes .
11970912	0	Interferon-gamma	0,16	RANTES	45,51	Interferon-gamma	RANTES	3458	6352	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Interferon-gamma enhances rhinovirus-induced RANTES secretion by airway epithelial cells .
9852039	0	Interferon-gamma	0,16	Rab5a	37,42	Interferon-gamma	Rab5a	3458	5868	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells .
16314732	0	Interferon-gamma	0,16	SOCS_3	52,58	Interferon-gamma	SOCS 3	3458	9021	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Interferon-gamma , but not interferon-alpha , induces SOCS_3 expression in human melanoma cell lines .
10102295	0	Interferon-gamma	0,16	STAT1	81,86	Interferon-gamma	STAT1	3458	6772	Gene	Gene	START_ENTITY|dep|mediated mediated|nmod|END_ENTITY	Interferon-gamma signaling in human_retinal_pigment_epithelial cells mediated by STAT1 , ICSBP , and IRF-1 transcription factors .
12868960	0	Interferon-gamma	0,16	STAT1	139,144	Interferon-gamma	STAT1	15978(Tax:10090)	20846(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|systems systems|nmod|macrophages macrophages|nmod|signal_transduction_and_activator_of_transduction_factor_1 signal_transduction_and_activator_of_transduction_factor_1|appos|END_ENTITY	Interferon-gamma regulates nucleoside transport systems in macrophages through signal_transduction_and_activator_of_transduction_factor_1 -LRB- STAT1 -RRB- - dependent and - independent signalling pathways .
21594375	0	Interferon-gamma	0,16	TNF	26,29	Interferon-gamma	TNF	3458	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|sensitivity sensitivity|compound|END_ENTITY	Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line .
18658050	0	Interferon-gamma	0,16	Th1	20,23	Interferon-gamma	Th1	15978(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|appos|cytokine cytokine|amod|END_ENTITY	Interferon-gamma , a Th1 cytokine , regulates fat inflammation : a role for adaptive immunity in obesity .
9582275	0	Interferon-gamma	0,16	Th1	31,34	Interferon-gamma	Th1	15978(Tax:10090)	57314(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway .
11059759	0	Interferon-gamma	0,16	caspase-8	36,45	Interferon-gamma	caspase-8	3458	841	Gene	Gene	treatment|amod|START_ENTITY elevates|nsubj|treatment elevates|dobj|expression expression|amod|END_ENTITY	Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast_tumor cells to a death receptor-induced mitochondria-operated apoptotic program .
15065018	0	Interferon-gamma	0,16	caspase-8	25,34	Interferon-gamma	caspase-8	3458	841	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter .
15065018	0	Interferon-gamma	0,16	caspase-8	86,95	Interferon-gamma	caspase-8	3458	841	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|affecting affecting|dobj|methylation methylation|nmod|promoter promoter|amod|END_ENTITY	Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter .
17525260	0	Interferon-gamma	0,16	caspase-8	149,158	Interferon-gamma	caspase-8	3458	841	Gene	Gene	sensitizes|amod|START_ENTITY resistant|nsubj|sensitizes resistant|nmod|up-regulation up-regulation|nmod|END_ENTITY	Interferon-gamma sensitizes resistant Ewing 's _ sarcoma cells to tumor_necrosis_factor_apoptosis-inducing_ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity .
17627812	0	Interferon-gamma	0,16	caspase-8	43,52	Interferon-gamma	caspase-8	3458	841	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio - and chemotherapy .
17302735	0	Interferon-gamma	0,16	cathepsin_G	27,38	Interferon-gamma	cathepsin G	493965(Tax:9685)	101098719	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Interferon-gamma regulates cathepsin_G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin_basic_protein in vitro .
11269728	0	Interferon-gamma	0,16	cathepsin_K	51,62	Interferon-gamma	cathepsin K	15978(Tax:10090)	13038(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interferon-gamma down-regulates gene expression of cathepsin_K in osteoclasts and inhibits osteoclast formation .
12943524	0	Interferon-gamma	0,16	claudin-1	32,41	Interferon-gamma	claudin-1	3458	9076	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Interferon-gamma down-regulates claudin-1 and impairs the epithelial barrier function in primary cultured human thyrocytes .
7904591	0	Interferon-gamma	0,16	dipeptidylpeptidase_IV	25,47	Interferon-gamma	dipeptidylpeptidase IV	3458	1803	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interferon-gamma induces dipeptidylpeptidase_IV expression in human glomerular epithelial cells .
15681246	0	Interferon-gamma	0,16	familial_Mediterranean_fever	27,55	Interferon-gamma	familial Mediterranean fever	3458	4210	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Interferon-gamma levels in familial_Mediterranean_fever .
11509334	0	Interferon-gamma	0,16	fractalkine	28,39	Interferon-gamma	fractalkine	3458	6376	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Interferon-gamma stimulates fractalkine expression in human bronchial epithelial cells and regulates mononuclear cell adherence .
7776981	0	Interferon-gamma	0,16	insulin-like_growth_factor-I	37,65	Interferon-gamma	insulin-like growth factor-I	3458	3479	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|compound|END_ENTITY	Interferon-gamma inhibits macrophage insulin-like_growth_factor-I synthesis at the transcriptional level .
12813035	0	Interferon-gamma	0,16	interferon_regulatory_factor-1	73,103	Interferon-gamma	interferon regulatory factor-1	3458	3659	Gene	Gene	augments|amod|START_ENTITY CARD4/NOD1|nsubj|augments CARD4/NOD1|advcl|END_ENTITY	Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon_regulatory_factor-1 in intestinal epithelial cells .
9010676	0	Interferon-gamma	0,16	interleukin-10	91,105	Interferon-gamma	interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inhibiting inhibiting|dobj|transcription transcription|amod|END_ENTITY	Interferon-gamma enhances tumor_necrosis_factor-alpha production by inhibiting early phase interleukin-10 transcription .
12626794	0	Interferon-gamma	0,16	interleukin-18_binding_protein	39,69	Interferon-gamma	interleukin-18 binding protein	3458	10068	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interferon-gamma induces expression of interleukin-18_binding_protein in fibroblast-like synoviocytes .
1637783	0	Interferon-gamma	0,16	interleukin-2	58,71	Interferon-gamma	interleukin-2	3458	3558	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|administration administration|nmod|END_ENTITY	Interferon-gamma induced by administration of recombinant interleukin-2 to patients with cancer : kinetics , dose dependence , and correlation with physiological and therapeutic response .
19514839	0	Interferon-gamma	0,16	interleukin-2	101,114	Interferon-gamma	interleukin-2	3458	3558	Gene	Gene	induced|nsubjpass|START_ENTITY induced|advcl|vitro vitro|nmod|END_ENTITY	Interferon-gamma is induced in human peripheral blood immune cells in vitro by sodium_stibogluconate / interleukin-2 and mediates its antitumor activity in vivo .
7540883	0	Interferon-gamma	0,16	interleukin-3	29,42	Interferon-gamma	interleukin-3	3458	3562	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Interferon-gamma upregulates interleukin-3 -LRB- IL-3 -RRB- receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production .
8156003	0	Interferon-gamma	0,16	interleukin-3	25,38	Interferon-gamma	interleukin-3	3458	3562	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Interferon-gamma induces interleukin-3 release from peripheral blood eosinophils .
17304101	0	Interferon-gamma	0,16	interleukin-8	101,114	Interferon-gamma	interleukin-8	3458	3576	Gene	Gene	lipopolysaccharide|amod|START_ENTITY act|nsubj|lipopolysaccharide act|nmod|neutrophils neutrophils|acl|enhancing enhancing|dobj|secretion secretion|amod|p70 p70|dep|END_ENTITY	Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8 , interleukin-1beta , tumor_necrosis_factor-alpha , and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like_receptor_4 .
8286750	0	Interferon-gamma	0,16	interleukin-8	29,42	Interferon-gamma	interleukin-8	3458	3576	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Interferon-gamma upregulates interleukin-8 gene expression in human monocytic cells by a posttranscriptional mechanism .
8473010	0	Interferon-gamma	0,16	interleukin-8	26,39	Interferon-gamma	interleukin-8	3458	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interferon-gamma inhibits interleukin-8 production by human polymorphonuclear leucocytes .
2867114	0	Interferon-gamma	0,16	interleukin_2	64,77	Interferon-gamma	interleukin 2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|dep|dependence dependence|nmod|END_ENTITY	Interferon-gamma induction by lipopolysaccharide : dependence on interleukin_2 and macrophages .
3084288	0	Interferon-gamma	0,16	interleukin_2	50,63	Interferon-gamma	interleukin 2	3458	3558	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Interferon-gamma induces light chain synthesis in interleukin_2 stimulated human B cells .
3102253	0	Interferon-gamma	0,16	interleukin_2	43,56	Interferon-gamma	interleukin 2	3458	3558	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	Interferon-gamma induces expression of the interleukin_2 receptor gene in human monocytes .
11838858	0	Interferon-gamma	0,16	interleukin_4	17,30	Interferon-gamma	interleukin 4	3458	3565	Gene	Gene	START_ENTITY|dep|ratios ratios|amod|END_ENTITY	Interferon-gamma : interleukin_4 ratios and associated type 1 cytokine expression in juvenile_rheumatoid_arthritis synovial tissue .
7526705	0	Interferon-gamma	0,16	interleukin_6	31,44	Interferon-gamma	interleukin 6	3458	3569	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Interferon-gamma regulation of interleukin_6 in monocytic cells .
15012733	0	Interferon-gamma	0,16	macrophage_migration_inhibitory_factor	25,63	Interferon-gamma	macrophage migration inhibitory factor	25712(Tax:10116)	103694877	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Interferon-gamma induces macrophage_migration_inhibitory_factor synthesis and secretion by tubular epithelial cells .
2503068	0	Interferon-gamma	0,16	major_histocompatibility_complex	30,62	Interferon-gamma	major histocompatibility complex	281237(Tax:9913)	515712(Tax:9913)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Interferon-gamma induction of major_histocompatibility_complex antigens on cultured bovine luteal cells .
2514776	0	Interferon-gamma	0,16	p17	118,121	Interferon-gamma	p17	3458	653820	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Interferon-gamma is associated with the surface of the human_immunodeficiency_virus and binds to the gag gene product p17 .
20195830	0	Interferon-gamma	0,16	p53	98,101	Interferon-gamma	p53	3458	7157	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Interferon-gamma enhances the apoptosis of macrophages under trophic stress through activation of p53 and the JAK1 pathway .
7723404	0	Interferon-gamma	0,16	p53	57,60	Interferon-gamma	p53	3458	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	Interferon-gamma inhibits apoptosis induced by wild-type p53 , cytotoxic anti-cancer agents and viability factor deprivation in myeloid cells .
8724359	0	Interferon-gamma	0,16	renin	55,60	Interferon-gamma	renin	3458	5972	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|END_ENTITY	Interferon-gamma inhibits the synthesis and release of renin from human decidual cells .
15370293	0	Interferon-gamma	0,16	retinoic_acid-inducible_gene-I	25,55	Interferon-gamma	retinoic acid-inducible gene-I	3458	23586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interferon-gamma induces retinoic_acid-inducible_gene-I in endothelial cells .
2161422	0	Interferon-gamma	0,16	thyroglobulin	46,59	Interferon-gamma	thyroglobulin	3458	7038	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Interferon-gamma inhibits thyrotropin-induced thyroglobulin gene transcription in cultured human thyrocytes .
2124978	0	Interferon-gamma	0,16	transforming_growth_factor-beta	93,124	Interferon-gamma	transforming growth factor-beta	3458	7040	Gene	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	Interferon-gamma reverses the stimulation of collagen but not fibronectin gene expression by transforming_growth_factor-beta in normal human fibroblasts .
8194369	0	Interferon-gamma	0,16	transforming_growth_factor-beta	39,70	Interferon-gamma	transforming growth factor-beta	3458	7040	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interferon-gamma induces high-affinity transforming_growth_factor-beta receptor expression on human corneal fibroblasts .
12423273	0	Interferon-gamma	0,16	tumor_necrosis_factor	58,79	Interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|releasing releasing|dobj|receptors receptors|compound|END_ENTITY	Interferon-gamma regulates apoptosis by releasing soluble tumor_necrosis_factor receptors in a gastric epithelial cell line .
1330686	0	Interferon-gamma	0,16	tumor_necrosis_factor	67,88	Interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|types types|nmod|receptors receptors|compound|END_ENTITY	Interferon-gamma induces cell surface expression for both types of tumor_necrosis_factor receptors .
3005410	0	Interferon-gamma	0,16	tumor_necrosis_factor	63,84	Interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|receptors receptors|nmod|END_ENTITY	Interferon-gamma enhances expression of cellular receptors for tumor_necrosis_factor .
3117888	2	Interferon-gamma	64,80	tumor_necrosis_factor	90,111	Interferon-gamma	tumor necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Interferon-gamma requires tumor_necrosis_factor to restrain tumor cell growth in peritoneal cell cultures from tumor-dormant mice .
12960156	0	Interferon-gamma	0,16	tumor_necrosis_factor-alpha	93,120	Interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	differentially|amod|START_ENTITY regulates|nsubj|differentially regulates|nmod|END_ENTITY	Interferon-gamma differentially regulates monocyte matrix metalloproteinase-1 and -9 through tumor_necrosis_factor-alpha and caspase_8 .
1516623	1	Interferon-gamma	54,70	tumor_necrosis_factor-alpha	107,134	Interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|cytokine cytokine|appos|END_ENTITY	I. Interferon-gamma in combination with a cytokine -LRB- not tumor_necrosis_factor-alpha -RRB- is required , but can not act alone in the inhibition of intracellular forms of L. aethiopica in THP1 cells .
16525716	0	Interferon-gamma	0,16	tumor_necrosis_factor-alpha	46,73	Interferon-gamma	tumor necrosis factor-alpha	25712(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|enzyme/a enzyme/a|amod|END_ENTITY	Interferon-gamma down-regulates expression of tumor_necrosis_factor-alpha converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats .
17051336	0	Interferon-gamma	0,16	tumor_necrosis_factor-alpha	72,99	Interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	sensitizes|nsubj|START_ENTITY sensitizes|dobj|line line|nmod|activation activation|amod|END_ENTITY	Interferon-gamma sensitizes the human salivary gland cell line , HSG , to tumor_necrosis_factor-alpha induced activation of dual apoptotic pathways .
7693830	0	Interferon-gamma	0,16	tumor_necrosis_factor-alpha	65,92	Interferon-gamma	tumor necrosis factor-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Interferon-gamma , but not interferon-alpha_beta , synergizes with tumor_necrosis_factor-alpha and lipid_A in the induction of nitric_oxide production by murine L929 cells .
17412608	0	Interferon-gamma	0,16	tumour_necrosis_factor	33,55	Interferon-gamma	tumour necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	synergises|nsubj|START_ENTITY synergises|nmod|END_ENTITY	Interferon-gamma synergises with tumour_necrosis_factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells .
2342469	0	Interferon-regulatory_factor_1	0,30	prolactin	94,103	Interferon-regulatory factor 1	prolactin	16362(Tax:10090)	19109(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Interferon-regulatory_factor_1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells .
12810567	0	Interferon-stimulated_gene-15	0,29	Isg15	31,36	Interferon-stimulated gene-15	Isg15	100038882(Tax:10090)	100038882(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interferon-stimulated_gene-15 -LRB- Isg15 -RRB- expression is up-regulated in the mouse uterus in response to the implanting conceptus .
10819777	0	Interferon-tau	0,14	granulocyte-macrophage_colony-stimulating_factor	26,74	Interferon-tau	granulocyte-macrophage colony-stimulating factor	317698(Tax:9913)	281095(Tax:9913)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Interferon-tau stimulates granulocyte-macrophage_colony-stimulating_factor gene expression in bovine lymphocytes and endometrial stromal cells .
26618646	0	Interferon-y	47,59	IFN-y	61,66	Interferon-y	IFN-y	3458	3458	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Aqueous_Tear_Deficiency Increases Conjunctival Interferon-y -LRB- IFN-y -RRB- Expression and Goblet Cell Loss .
24479685	0	Interferon-y	0,12	LRRK2	48,53	Interferon-y	LRRK2	3458	120892	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interferon-y induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages .
22295238	0	Interferon_Regulatory_Factor-1	12,42	IRF1	44,48	Interferon Regulatory Factor-1	IRF1	3659	3659	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Interferon_Regulatory_Factor-1 -LRB- IRF1 -RRB- in Overcoming Antiestrogen Resistance in the Treatment of Breast_Cancer .
25342322	0	Interferon_Regulatory_Factor-1	0,30	Phosphatidylserine_Receptor	71,98	Interferon Regulatory Factor-1	Phosphatidylserine Receptor	3659	23210	Gene	Gene	Involved|nsubj|START_ENTITY Involved|nmod|Induction Induction|nmod|END_ENTITY	Interferon_Regulatory_Factor-1 -LRB- IRF-1 -RRB- Is Involved in the Induction of Phosphatidylserine_Receptor -LRB- PSR -RRB- in Response to dsRNA Virus Infection and Contributes to Apoptotic Cell Clearance in CHSE-214 Cell .
22200613	0	Interferon_Regulatory_Factor_1	0,30	p21	47,50	Interferon Regulatory Factor 1	p21	3659	1026	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interferon_Regulatory_Factor_1 -LRB- IRF-1 -RRB- induces p21 -LRB- WAF1/CIP1 -RRB- dependent cell cycle arrest and p21 -LRB- WAF1/CIP1 -RRB- independent modulation of survivin in cancer cells .
2633333	0	Interferon_beta_2	0,17	interleukin-6	18,31	Interferon beta 2	interleukin-6	3569	3569	Gene	Gene	/|compound|START_ENTITY /|amod|END_ENTITY	Interferon_beta_2 / interleukin-6 and interleukin-3 synergize in stimulating proliferation of human early hematopoietic progenitor cells .
2472425	0	Interferon_beta_2	0,17	interleukin_6	18,31	Interferon beta 2	interleukin 6	3569	3569	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|END_ENTITY	Interferon_beta_2 / interleukin_6 modulates synthesis of alpha_1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells .
7520470	0	Interferon_gamma	0,16	CD38	59,63	Interferon gamma	CD38	3458	952	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interferon_gamma selectively inhibits very primitive CD342 + CD38 - and not more mature CD34 + CD38 + human hematopoietic progenitor cells .
10452631	0	Interferon_gamma	0,16	IFN-gamma	18,27	Interferon gamma	IFN-gamma	3458	3458	Gene	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Interferon_gamma -LRB- IFN-gamma -RRB- deficiency in generalized Epstein-Barr_virus infection with interstitial lymphoid and granulomatous_pneumonia , focal cerebral_lesions , and genital ulcers : remission following IFN-gamma substitution therapy .
7519632	0	Interferon_gamma	0,16	alpha_2_macroglobulin	30,51	Interferon gamma	alpha 2 macroglobulin	3458	2	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Interferon_gamma up-regulates alpha_2_macroglobulin expression in human astrocytoma cells .
22447512	0	Interferon_gamma	0,16	frataxin	29,37	Interferon gamma	frataxin	3458	2395	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Interferon_gamma upregulates frataxin and corrects the functional deficits in a Friedreich_ataxia model .
1904523	0	Interferon_gamma	0,16	interleukin_1	41,54	Interferon gamma	interleukin 1	15978(Tax:10090)	111343(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|nmod|END_ENTITY	Interferon_gamma modulates production of interleukin_1 and tumor_necrosis_factor by murine Kupffer cells .
8426121	0	Interferon_gamma	0,16	interleukin_10	26,40	Interferon gamma	interleukin 10	3458	3586	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interferon_gamma inhibits interleukin_10 production by monocytes .
8879215	0	Interferon_gamma	0,16	platelet_endothelial_cell_adhesion_molecule_1	27,72	Interferon gamma	platelet endothelial cell adhesion molecule 1	15978(Tax:10090)	18613(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interferon_gamma regulates platelet_endothelial_cell_adhesion_molecule_1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas .
12947309	0	Interferon_regulatory_factor-1	0,30	IP-10	63,68	Interferon regulatory factor-1	IP-10	16362(Tax:10090)	15945(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	Interferon_regulatory_factor-1 down-regulates cytokine-induced IP-10 expression in pancreatic islets .
9115258	0	Interferon_regulatory_factor-1	0,30	angiotensin_II_type_2_receptor	44,74	Interferon regulatory factor-1	angiotensin II type 2 receptor	16362(Tax:10090)	11609(Tax:10090)	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Interferon_regulatory_factor-1 up-regulates angiotensin_II_type_2_receptor and induces apoptosis .
21740303	0	Interferon_regulatory_factor-1	0,30	c-Cbl	37,42	Interferon regulatory factor-1	c-Cbl	3659	867	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Interferon_regulatory_factor-1 binds c-Cbl , enhances mitogen activated protein kinase signaling and promotes retinoic_acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells .
12545159	0	Interferon_regulatory_factor-1	0,30	interferon-gamma	57,73	Interferon regulatory factor-1	interferon-gamma	3659	3458	Gene	Gene	mediator|nsubj|START_ENTITY mediator|nmod|attenuation attenuation|amod|END_ENTITY	Interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression .
24412152	0	Interferon_regulatory_factor-1	0,30	regulated_in_development_and_DNA_damage_response_2	54,104	Interferon regulatory factor-1	regulated in development and DNA damage response 2	16362(Tax:10090)	73284(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- interacts with regulated_in_development_and_DNA_damage_response_2 -LRB- REDD2 -RRB- in the cytoplasm of mouse bone marrow cells .
11867762	0	Interferon_regulatory_factor-3	0,30	DNA-PK	55,61	Interferon regulatory factor-3	DNA-PK	3661	5591	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Interferon_regulatory_factor-3 is an in vivo target of DNA-PK .
7823961	0	Interferon_regulatory_factor_1	0,30	Gbp	53,56	Interferon regulatory factor 1	Gbp	16362(Tax:10090)	16854(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Interferon_regulatory_factor_1 is required for mouse Gbp gene activation by gamma interferon .
16219795	0	Interferon_regulatory_factor_3	0,30	Toll-like_receptor_4	46,66	Interferon regulatory factor 3	Toll-like receptor 4	3661	7099	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Interferon_regulatory_factor_3 is involved in Toll-like_receptor_4 -LRB- TLR4 -RRB- - and TLR3-induced IL-12p35 gene activation .
11956291	0	Interferon_regulatory_factor_4	0,30	NFATc2	53,59	Interferon regulatory factor 4	NFATc2	16364(Tax:10090)	18019(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Interferon_regulatory_factor_4 -LRB- IRF4 -RRB- interacts with NFATc2 to modulate interleukin_4 gene expression .
22888789	0	Interferon_regulatory_factor_4_binding_protein	0,46	p53	58,61	Interferon regulatory factor 4 binding protein	p53	50619	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Interferon_regulatory_factor_4_binding_protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast_cancer cells .
11119603	0	Interferon_regulatory_factor_7	0,30	Tap-2	54,59	Interferon regulatory factor 7	Tap-2	3665	6891	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Interferon_regulatory_factor_7 mediates activation of Tap-2 by Epstein-Barr_virus latent membrane protein 1 .
25331958	0	Interferon_regulatory_factor_8	0,30	BCOR	94,98	Interferon regulatory factor 8	BCOR	15900(Tax:10090)	71458(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Interferon_regulatory_factor_8 -LRB- IRF8 -RRB- interacts with the B_cell_lymphoma 6 -LRB- BCL6 -RRB- corepressor BCOR .
16707500	0	Interferon_regulatory_factor_8	0,30	RANTES	41,47	Interferon regulatory factor 8	RANTES	3394	6352	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Interferon_regulatory_factor_8 regulates RANTES gene transcription in cooperation with interferon_regulatory_factor-1 , NF-kappaB , and PU .1 .
23020843	0	Interferon_regulatory_factor_8	0,30	interferon_consensus_sequence_binding_protein	31,76	Interferon regulatory factor 8	interferon consensus sequence binding protein	15900(Tax:10090)	15900(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|factor factor|nsubj|END_ENTITY	Interferon_regulatory_factor_8 / interferon_consensus_sequence_binding_protein is a critical transcription factor for the physiological phenotype of microglia .
16707500	0	Interferon_regulatory_factor_8	0,30	interferon_regulatory_factor-1	87,117	Interferon regulatory factor 8	interferon regulatory factor-1	3394	3659	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Interferon_regulatory_factor_8 regulates RANTES gene transcription in cooperation with interferon_regulatory_factor-1 , NF-kappaB , and PU .1 .
17971486	0	Interferon_regulatory_factors_4_and_8	0,37	Ikaros	63,69	Interferon regulatory factors 4 and 8	Ikaros	3662;3394	10320	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Interferon_regulatory_factors_4_and_8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development .
22384041	0	Interleukin-1	0,13	ADAM17	25,31	Interleukin-1	ADAM17	3552	6868	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735 .
2799385	0	Interleukin-1	0,13	AP-1	71,75	Interleukin-1	AP-1	3552	2353	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1 .
11485304	0	Interleukin-1	0,13	FGF-2	24,29	Interleukin-1	FGF-2	3552	2247	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|mRNA mRNA|compound|END_ENTITY	Interleukin-1 regulates FGF-2 mRNA and localization of FGF-2 protein in human osteoblasts .
1533794	0	Interleukin-1	0,13	IL-1	15,19	Interleukin-1	IL-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Interleukin-1 -LRB- IL-1 -RRB- receptors on murine splenic B cells and the 70Z/3 pre-B-cell line appear to be identical and bind human IL-1_alpha and IL-1_beta differentially .
2138628	0	Interleukin-1	0,13	IL-1	15,19	Interleukin-1	IL-1	3552	3552	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Interleukin-1 -LRB- IL-1 -RRB- regulation of human endometrial function : presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin_E2 production .
3010001	0	Interleukin-1	0,13	IL1	20,23	Interleukin-1	IL1	3552	3552	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin-1 gene -LRB- IL1 -RRB- assigned to long arm of human chromosome 2 .
20079164	0	Interleukin-1	0,13	Sox9	23,27	Interleukin-1	Sox9	3552	6662	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear_factor-kappaB in the cultured human intervertebral disc cells .
2821621	0	Interleukin-1	0,13	corticotropin-releasing_factor	55,85	Interleukin-1	corticotropin-releasing factor	3552	1392	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing_factor .
7886628	0	Interleukin-1	0,13	corticotropin-releasing_factor	28,58	Interleukin-1	corticotropin-releasing factor	3552	1392	Gene	Gene	alpha|compound|START_ENTITY induces|nsubj|alpha induces|dobj|secretion secretion|amod|END_ENTITY	Interleukin-1 alpha induces corticotropin-releasing_factor secretion and synthesis from NPLC-KC cells through various second messenger pathways .
9607726	0	Interleukin-1	0,13	corticotropin-releasing_factor	28,58	Interleukin-1	corticotropin-releasing factor	3552	1392	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Interleukin-1 regulation of corticotropin-releasing_factor -LRB- CRF -RRB- , glucocorticoid_receptor , c-fos and c-jun messenger RNA in the NPLC-KC cell line .
1874173	0	Interleukin-1	0,13	cytochrome_P450	55,70	Interleukin-1	cytochrome P450	3552	4051	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Interleukin-1 inhibits cholesterol side-chain cleavage cytochrome_P450 expression in primary cultures of Leydig cells .
2478229	0	Interleukin-1	0,13	granulocyte-macrophage_colony-stimulating_factor	30,78	Interleukin-1	granulocyte-macrophage colony-stimulating factor	3552	1437	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Interleukin-1 synergizes with granulocyte-macrophage_colony-stimulating_factor on granulocytic colony formation by intermediate production of granulocyte colony-stimulating factor .
15831712	0	Interleukin-1	0,13	growth_hormone	72,86	Interleukin-1	growth hormone	3552	2688	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth_hormone in CWSV-1 hepatocytes .
1533388	0	Interleukin-1	0,13	interleukin-2	124,137	Interleukin-1	interleukin-2	3552	3558	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Interleukin-1 down-regulates gene and surface expression of interleukin-1_receptor_type_I by destabilizing its mRNA whereas interleukin-2 increases its expression .
1493810	0	Interleukin-1	0,13	interleukin-6	99,112	Interleukin-1	interleukin-6	3552	3569	Gene	Gene	factor|nsubj|START_ENTITY factor|dep|effect effect|nmod|END_ENTITY	Interleukin-1 is a motility factor for human breast_carcinoma cells in vitro : additive effect with interleukin-6 .
21795706	0	Interleukin-1	0,13	interleukin-6	37,50	Interleukin-1	interleukin-6	3552	3569	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|synthesis synthesis|nmod|mechanism mechanism|amod|END_ENTITY	Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type_splicing_regulatory_protein -LRB- KSRP -RRB- - dependent translational silencing mechanism .
2786435	0	Interleukin-1	0,13	interleukin-6	68,81	Interleukin-1	interleukin-6	3552	3569	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|END_ENTITY	Interleukin-1 accelerates autocrine growth of myeloma_cells through interleukin-6 in human myeloma .
8391194	0	Interleukin-1	0,13	interleukin-6	40,53	Interleukin-1	interleukin-6	3552	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|cells cells|amod|END_ENTITY	Interleukin-1 stimulates the release of interleukin-6 from cultured human pituitary_adenoma cells .
7994038	0	Interleukin-1	0,13	interleukin-8	22,35	Interleukin-1	interleukin-8	3552	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism .
3257870	0	Interleukin-1	0,13	phospholipase_A2	24,40	Interleukin-1	phospholipase A2	3552	151056	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Interleukin-1 activates phospholipase_A2 in human synovial cells .
8178956	0	Interleukin-1	0,13	phospholipase_D	52,67	Interleukin-1	phospholipase D	3552	2822	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Interleukin-1 stimulates phosphatidic_acid-mediated phospholipase_D activity in human mesangial cells .
19074142	0	Interleukin-1	0,13	sphingosine_kinase_1	42,62	Interleukin-1	sphingosine kinase 1	3552	8877	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-1 regulates the expression of sphingosine_kinase_1 in glioblastoma cells .
2788696	0	Interleukin-1	0,13	thyroglobulin	50,63	Interleukin-1	thyroglobulin	3552	7038	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Interleukin-1 inhibits thyrotrophin-induced human thyroglobulin gene expression .
3262504	0	Interleukin-1	0,13	transforming_growth_factor-alpha	34,66	Interleukin-1	transforming growth factor-alpha	3552	7124	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Interleukin-1 in combination with transforming_growth_factor-alpha produces enhanced bone resorption in vitro .
10506136	0	Interleukin-1	0,13	tumor_necrosis_factor-related_apoptosis-inducing_ligand	54,109	Interleukin-1	tumor necrosis factor-related apoptosis-inducing ligand	3552	8743	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|amod|END_ENTITY	Interleukin-1 protects transformed keratinocytes from tumor_necrosis_factor-related_apoptosis-inducing_ligand - and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis .
17390208	0	Interleukin-1	0,13	vascular_endothelial_growth_factor	40,74	Interleukin-1	vascular endothelial growth factor	3552	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin-1 induces the expression of vascular_endothelial_growth_factor in human pericardial mesothelial cells .
10771998	0	Interleukin-1-beta	0,18	insulin	49,56	Interleukin-1-beta	insulin	3553	3630	Gene	Gene	START_ENTITY|appos|secretion secretion|compound|END_ENTITY	Interleukin-1-beta , tumor_necrosis_factor-alpha , insulin secretion and oral glucose tolerance in non-diabetic siblings of children with IDDM .
26600159	0	Interleukin-10	84,98	ABO_Blood_Group	50,65	Interleukin-10	ABO Blood Group	3586	28	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Genome-Wide Association Study Identifies That the ABO_Blood_Group System Influences Interleukin-10 Levels and the Risk of Clinical Events in Patients with Acute_Coronary_Syndrome .
7589143	0	Interleukin-10	0,14	B7-1	40,44	Interleukin-10	B7-1	3586	941	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Interleukin-10 differentially regulates B7-1 -LRB- CD80 -RRB- and B7-2 -LRB- CD86 -RRB- expression on human peripheral blood dendritic cells .
8839847	0	Interleukin-10	0,14	Bcl-2	25,30	Interleukin-10	Bcl-2	3586	596	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Interleukin-10 increases Bcl-2 expression and survival in primary human CD34 + hematopoietic progenitor cells .
9370916	0	Interleukin-10	0,14	Bcl-2	94,99	Interleukin-10	Bcl-2	3586	596	Gene	Gene	rescues|nsubj|START_ENTITY rescues|parataxis|association association|nmod|upregulation upregulation|nmod|END_ENTITY	Interleukin-10 rescues T cells from apoptotic cell death : association with an upregulation of Bcl-2 .
12219016	0	Interleukin-10	0,14	C/EBP	50,55	Interleukin-10	C/EBP	3586	1050	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells .
15325277	0	Interleukin-10	0,14	CD14	103,107	Interleukin-10	CD14	3586	929	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|development development|nmod|population population|nmod|+ +|compound|END_ENTITY	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
19796181	0	Interleukin-10	0,14	CD14	30,34	Interleukin-10	CD14	3586	929	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|cells cells|nummod|END_ENTITY	Interleukin-10 secretion from CD14 + peripheral blood mononuclear cells is downregulated in patients with acne_vulgaris .
15325277	0	Interleukin-10	0,14	CD16	108,112	Interleukin-10	CD16	3586	2214	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|development development|nmod|population population|nmod|+ +|compound|END_ENTITY	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
8839847	0	Interleukin-10	0,14	CD34	72,76	Interleukin-10	CD34	3586	947	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Interleukin-10 increases Bcl-2 expression and survival in primary human CD34 + hematopoietic progenitor cells .
11529935	0	Interleukin-10	0,14	CD4	80,83	Interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressed|advmod|START_ENTITY expressed|dep|induces induces|dobj|generation generation|nmod|T-regulatory T-regulatory|compound|END_ENTITY	Interleukin-10 expressed at early_tumour sites induces subsequent generation of CD4 -LRB- + -RRB- T-regulatory cells and systemic collapse of antitumour immunity .
21817097	0	Interleukin-10	0,14	CD4	27,30	Interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	released|advmod|START_ENTITY released|nmod|CD25 CD25|compound|END_ENTITY	Interleukin-10 released by CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice .
7510582	0	Interleukin-10	0,14	CD4	37,40	Interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Interleukin-10 production by splenic CD4 + cells and cell subsets from young and old mice .
8691133	0	Interleukin-10	0,14	CD4	75,78	Interleukin-10	CD4	3586	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|state state|nmod|cells cells|compound|END_ENTITY	Interleukin-10 induces a long-term antigen-specific anergic state in human CD4 + T cells .
8840221	0	Interleukin-10	0,14	CD4	107,110	Interleukin-10	CD4	3586	920	Gene	Gene	secretion|amod|START_ENTITY secretion|dep|T T|compound|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- secretion in systemic_lupus_erythematosus and rheumatoid_arthritis : IL-10-dependent CD4 + CD45RO + T cell-B cell antibody synthesis .
9825821	0	Interleukin-10	0,14	CD4	44,47	Interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|+ +|compound|END_ENTITY	Interleukin-10 dose-dependent regulation of CD4 + and CD8 + T cell-mediated graft-versus-host_disease .
9720722	0	Interleukin-10	0,14	CD5	79,82	Interleukin-10	CD5	3586	921	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|B-cells B-cells|compound|END_ENTITY	Interleukin-10 inhibits the in vitro proliferation of human activated leukemic CD5 + B-cells .
11568001	0	Interleukin-10	0,14	CD8	53,56	Interleukin-10	CD8	3586	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|maintenance maintenance|nmod|T-cell T-cell|compound|END_ENTITY	Interleukin-10 promotes the maintenance of antitumor CD8 -LRB- + -RRB- T-cell effector function in situ .
12508773	0	Interleukin-10	0,14	CD8	64,67	Interleukin-10	CD8	3586	925	Gene	Gene	expression|amod|START_ENTITY expression|parataxis|contribution contribution|nmod|cells cells|compound|END_ENTITY	Interleukin-10 expression : is there a neglected contribution of CD8 + T cells in rheumatoid_arthritis joints ?
16287061	0	Interleukin-10	0,14	CD8	62,65	Interleukin-10	CD8	3586	925	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|infiltration infiltration|compound|END_ENTITY	Interleukin-10 expression significantly correlates with minor CD8 + T-cell infiltration and high microvessel density in patients with gastric_cancer .
8624379	0	Interleukin-10	0,14	CD8	116,119	Interleukin-10	CD8	3586	925	Gene	Gene	influence|nsubj|START_ENTITY influence|dobj|proliferation proliferation|nmod|+ +|compound|END_ENTITY	Interleukin-10 , interleukin-12 , and tumor_necrosis_factor-alpha differentially influence the proliferation of human CD8 + and CD4 + T-cell clones .
9064342	0	Interleukin-10	0,14	E-selectin	23,33	Interleukin-10	E-selectin	3586	6401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin-10 induces E-selectin on small and large blood vessel endothelial cells .
10580805	0	Interleukin-10	0,14	IL10	16,20	Interleukin-10	IL10	3586	3586	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Interleukin-10 -LRB- IL10 -RRB- promoter polymorphisms and multiple_sclerosis .
15325277	0	Interleukin-10	0,14	M-CSF	35,40	Interleukin-10	M-CSF	3586	1435	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
17627913	0	Interleukin-10	0,14	NFATc1	53,59	Interleukin-10	NFATc1	16153(Tax:10090)	18018(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264 .7 cells and mouse bone marrow cells .
18093541	0	Interleukin-10	0,14	Pbx1	116,120	Interleukin-10	Pbx1	3586	5087	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|nmod|END_ENTITY	Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1 .
11083779	0	Interleukin-10	0,14	THP-1	84,89	Interleukin-10	THP-1	3586	2736	Gene	Gene	modulates|amod|START_ENTITY cytokines|nsubj|modulates cytokines|nmod|END_ENTITY	Interleukin-10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia_burgdorferi lipoproteins .
17689273	0	Interleukin-10	0,14	THP-1	118,123	Interleukin-10	THP-1	3586	2736	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|factor-alpha factor-alpha|nmod|cells cells|amod|macrophage-derived macrophage-derived|amod|END_ENTITY	Interleukin-10 inhibits the down-regulation of ATP_binding_cassette_transporter_A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells .
18023359	0	Interleukin-10	0,14	TNF-alpha	50,59	Interleukin-10	TNF-alpha	3586	7124	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro .
23141143	0	Interleukin-10	0,14	Toll-like_receptor_4	25,45	Interleukin-10	Toll-like receptor 4	3586	7099	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Interleukin-10 activates Toll-like_receptor_4 and requires MyD88 for cardiomyocyte survival .
17652887	0	Interleukin-10	0,14	adiponectin	31,42	Interleukin-10	adiponectin	3586	9370	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Interleukin-10 associates with adiponectin predominantly in subjects with metabolic_syndrome .
8282815	0	Interleukin-10	0,14	bcl-2	89,94	Interleukin-10	bcl-2	3586	596	Gene	Gene	prevents|nsubj|START_ENTITY prevents|nmod|induction induction|nmod|protein protein|amod|END_ENTITY	Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein .
23364980	0	Interleukin-10	0,14	cathepsin_B	30,41	Interleukin-10	cathepsin B	25325(Tax:10116)	64529(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Interleukin-10 down-regulates cathepsin_B expression in fetal rat alveolar type II cells exposed to hyperoxia .
19074677	0	Interleukin-10	0,14	endothelin-1	48,60	Interleukin-10	endothelin-1	16153(Tax:10090)	13614(Tax:10090)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway .
18405889	0	Interleukin-10	0,14	granzyme_B	54,64	Interleukin-10	granzyme B	3586	3002	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Interleukin-10 containing normal human serum inhibits granzyme_B release but not perforin release from alloreactive and EBV-specific T cell clones .
12774458	0	Interleukin-10	0,14	inducible_nitric_oxide_synthase	24,55	Interleukin-10	inducible nitric oxide synthase	25325(Tax:10116)	24599(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interleukin-10 inhibits inducible_nitric_oxide_synthase in an animal model of necrotizing_enterocolitis .
10210769	0	Interleukin-10	0,14	interferon-gamma	35,51	Interleukin-10	interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Interleukin-10 in combination with interferon-gamma and tumor_necrosis_factor-alpha enhances in vitro production of nitric_oxide by murine resident paritoneal macrophage .
11172617	0	Interleukin-10	0,14	interferon-gamma	50,66	Interleukin-10	interferon-gamma	3586	3458	Gene	Gene	relieves|nsubj|START_ENTITY relieves|dobj|effects effects|nmod|END_ENTITY	Interleukin-10 relieves the inhibitory effects of interferon-gamma on normal human lung fibroblasts .
1371674	0	Interleukin-10	0,14	interferon-gamma	74,90	Interleukin-10	interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- inhibits the induction of nitric_oxide synthase by interferon-gamma in murine macrophages .
8181527	0	Interleukin-10	0,14	interferon-gamma	24,40	Interleukin-10	interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|compound|END_ENTITY	Interleukin-10 controls interferon-gamma and tumor_necrosis_factor production during experimental endotoxemia .
20937231	0	Interleukin-10	1,15	interferon_regulatory_factor-1	43,73	Interleukin-10	interferon regulatory factor-1	3586	3659	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	-LSB- Interleukin-10 inhibits the expression of interferon_regulatory_factor-1 with anoxia-reoxygenation in vitro -RSB- .
12394188	0	Interleukin-10	0,14	interleukin-6	16,29	Interleukin-10	interleukin-6	3586	3569	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Interleukin-10 , interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients .
18684450	0	Interleukin-10	0,14	interleukin-6	44,57	Interleukin-10	interleukin-6	3586	3569	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|amod|END_ENTITY	Interleukin-10 attenuates TNF-alpha-induced interleukin-6 production in endometriotic stromal cells .
7725065	0	Interleukin-10	0,14	interleukin-6	37,50	Interleukin-10	interleukin-6	3586	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin-10 directly inhibits the interleukin-6 production in T-cells .
8344757	0	Interleukin-10	0,14	interleukin-6	80,93	Interleukin-10	interleukin-6	3586	3569	Gene	Gene	production|amod|START_ENTITY production|nmod|expression expression|amod|END_ENTITY	Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression .
8885776	0	Interleukin-10	0,14	interleukin-6	29,42	Interleukin-10	interleukin-6	3586	3569	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Interleukin-10 inhibition of interleukin-6 in human amniochorionic membrane : transcriptional regulation .
12507912	0	Interleukin-10	0,14	interleukin-8	43,56	Interleukin-10	interleukin-8	3586	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Interleukin-10 inhibits elevated chemokine interleukin-8 and regulated on activation normal T cell expressed and secreted production in cystic_fibrosis bronchial epithelial cells by targeting the I -LRB- k -RRB- B kinase alpha/beta complex .
8167346	0	Interleukin-10	0,14	interleukin-8	24,37	Interleukin-10	interleukin-8	3586	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin-10 inhibits interleukin-8 production in human neutrophils .
12488502	0	Interleukin-10	0,14	monocyte_chemoattractant_protein-1	37,71	Interleukin-10	monocyte chemoattractant protein-1	3586	6347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interleukin-10 differently regulates monocyte_chemoattractant_protein-1 gene expression depending on the environment in a human monoblastic cell line , UG3 .
12857749	0	Interleukin-10	0,14	nitric-oxide_synthase	28,49	Interleukin-10	nitric-oxide synthase	3586	4846	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Interleukin-10 induction of nitric-oxide_synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells .
11447117	0	Interleukin-10	0,14	p38_MAPK	23,31	Interleukin-10	p38 MAPK	16153(Tax:10090)	26416(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Interleukin-10 targets p38_MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology .
11254592	0	Interleukin-10	0,14	tumor_necrosis_factor	83,104	Interleukin-10	tumor necrosis factor	3586	7124	Gene	Gene	Coxiella_burnetii|compound|START_ENTITY Coxiella_burnetii|acl|replication replication|nmod|down-modulation down-modulation|compound|END_ENTITY	Interleukin-10 stimulates Coxiella_burnetii replication in human monocytes through tumor_necrosis_factor down-modulation : role in microbicidal defect of Q_fever .
8646564	0	Interleukin-10	0,14	tumor_necrosis_factor	51,72	Interleukin-10	tumor necrosis factor	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interleukin-10 inhibits lipopolysaccharide-induced tumor_necrosis_factor and interleukin-1 beta production in the brain without affecting the activation of the hypothalamus-pituitary-adrenal_axis .
8648229	0	Interleukin-10	0,14	tumor_necrosis_factor	27,48	Interleukin-10	tumor necrosis factor	3586	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Interleukin-10 and soluble tumor_necrosis_factor receptors in cerebrospinal fluid of children with bacterial_meningitis .
8699123	0	Interleukin-10	0,14	tumor_necrosis_factor	46,67	Interleukin-10	tumor necrosis factor	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Interleukin-10 inhibits interleukin-2-induced tumor_necrosis_factor production but does not reduce toxicity in C3H/HeN mice .
18787467	0	Interleukin-10	0,14	tumor_necrosis_factor-alpha	133,160	Interleukin-10	tumor necrosis factor-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	biomarker|nsubj|START_ENTITY biomarker|nmod|fatty_liver_disease fatty_liver_disease|amod|interleukin-10 interleukin-10|nmod|ratio ratio|amod|END_ENTITY	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
18787467	0	Interleukin-10	0,14	tumor_necrosis_factor-alpha	18,45	Interleukin-10	tumor necrosis factor-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
11695989	0	Interleukin-10	0,14	tumour-necrosis-factor-alpha-related_apoptosis-inducing_ligand	28,90	Interleukin-10	tumour-necrosis-factor-alpha-related apoptosis-inducing ligand	16153(Tax:10090)	22035(Tax:10090)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- gene expression in mammary epithelial cells at the involution stage .
19716605	0	Interleukin-11	0,14	STAT3	83,88	Interleukin-11	STAT3	3589	6774	Gene	Gene	increases|nsubj|START_ENTITY increases|advcl|modulating modulating|dobj|expression expression|compound|END_ENTITY	Interleukin-11 increases invasiveness of JEG-3 choriocarcinoma cells by modulating STAT3 expression .
24504547	0	Interleukin-11	0,14	matrix_metalloproteinase_13	41,68	Interleukin-11	matrix metalloproteinase 13	3589	4322	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin-11 induces the expression of matrix_metalloproteinase_13 in gastric_cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways .
7694867	0	Interleukin-11	0,14	stem_cell_factor	117,133	Interleukin-11	stem cell factor	3589	4254	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|proliferation proliferation|dep|cells cells|nmod|END_ENTITY	Interleukin-11 stimulates the proliferation of human hematopoietic CD34 + and CD34 + CD33-DR - cells and synergizes with stem_cell_factor , interleukin-3 , and granulocyte-macrophage_colony-stimulating_factor .
18367309	0	Interleukin-12_p40	0,18	IL12B	25,30	Interleukin-12 p40	IL12B	3593	3593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin-12_p40 gene -LRB- IL12B -RRB- polymorphisms and the risk of cervical_cancer in Korean women .
16005098	0	Interleukin-12p40	0,17	IL-12B	24,30	Interleukin-12p40	IL-12B	3593	3593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin-12p40 gene -LRB- IL-12B -RRB- polymorphism and Type_1_diabetes_mellitus in Japanese : possible role in subjects without having high-risk HLA haplotypes .
12748293	0	Interleukin-13	0,14	15-lipoxygenase	28,43	Interleukin-13	15-lipoxygenase	3596	246	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Interleukin-13 induction of 15-lipoxygenase gene expression requires p38_mitogen-activated_protein_kinase-mediated serine 727 phosphorylation of Stat1 and Stat3 .
25597757	0	Interleukin-13	0,14	Alix	38,42	Interleukin-13	Alix	16163(Tax:10090)	18571(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Interleukin-13 promotes expression of Alix to compromise renal tubular epithelial barrier function .
26646664	0	Interleukin-13	0,14	BPIFA1	51,57	Interleukin-13	BPIFA1	3596	51297	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Interleukin-13 Inhibits Lipopolysaccharide-Induced BPIFA1 Expression in Nasal Epithelial Cells .
20030665	0	Interleukin-13	0,14	CCL11	58,63	Interleukin-13	CCL11	16163(Tax:10090)	20292(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|nmod|END_ENTITY	Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils .
9192766	0	Interleukin-13	0,14	CD40_ligand	35,46	Interleukin-13	CD40 ligand	3596	959	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Interleukin-13 in combination with CD40_ligand potently inhibits apoptosis in human B lymphocytes : upregulation of Bcl-xL and Mcl-1 .
17553491	0	Interleukin-13	0,14	CFTR	31,35	Interleukin-13	CFTR	3596	1080	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation .
11893731	0	Interleukin-13	0,14	GATA-3	47,53	Interleukin-13	GATA-3	16163(Tax:10090)	14462(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Interleukin-13 gene expression is regulated by GATA-3 in T cells : role of a critical association of a GATA and two GATG motifs .
8605347	0	Interleukin-13	0,14	IL-1_receptor_antagonist	31,55	Interleukin-13	IL-1 receptor antagonist	3596	3557	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-13 -LRB- IL-13 -RRB- induces IL-1_receptor_antagonist gene expression and protein synthesis in peripheral blood mononuclear cells : inhibition by an IL-4 mutant protein .
7908231	0	Interleukin-13	0,14	IL-1ra	76,82	Interleukin-13	IL-1ra	3596	3557	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Interleukin-13 induces the production of interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- and the expression of the mRNA for the intracellular -LRB- keratinocyte -RRB- form of IL-1ra in human myelomonocytic cells .
16818793	0	Interleukin-13	0,14	cyclooxygenase-2	24,40	Interleukin-13	cyclooxygenase-2	116553(Tax:10116)	29527(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia : implications for death of activated microglia .
7909299	0	Interleukin-13	0,14	interleukin-6	26,39	Interleukin-13	interleukin-6	3596	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Interleukin-13 stimulates interleukin-6 production by human keratinocytes .
9794606	0	Interleukin-13	0,14	macrophage_inflammatory_protein-1_alpha	67,106	Interleukin-13	macrophage inflammatory protein-1 alpha	3596	6348	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-13 down-regulates the expression of neutrophil-derived macrophage_inflammatory_protein-1_alpha .
9301536	0	Interleukin-13	0,14	monocyte_chemoattractant_protein-1	35,69	Interleukin-13	monocyte chemoattractant protein-1	3596	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Interleukin-13 selectively induces monocyte_chemoattractant_protein-1 synthesis and secretion by human endothelial cells .
10886401	0	Interleukin-15	0,14	CD154	46,51	Interleukin-15	CD154	3600	959	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-15 up-regulates the expression of CD154 on synovial fluid T cells .
17644042	0	Interleukin-15	0,14	CD28	41,45	Interleukin-15	CD28	3600	940	Gene	Gene	expands|nsubj|START_ENTITY expands|dobj|END_ENTITY	Interleukin-15 selectively expands CD57 + CD28 - CD4 + T cells , which are increased in active rheumatoid_arthritis .
9326248	0	Interleukin-15	0,14	IL-8	31,35	Interleukin-15	IL-8	3600	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Interleukin-15 -LRB- IL-15 -RRB- induces IL-8 and monocyte_chemotactic_protein_1 production in human monocytes .
10882748	0	Interleukin-15	0,14	STAT6	57,62	Interleukin-15	STAT6	16168(Tax:10090)	20852(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells .
10233697	0	Interleukin-15	0,14	interferon-gamma	57,73	Interleukin-15	interferon-gamma	3600	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Interleukin-15 differentially enhances the expression of interferon-gamma and interleukin-4 in activated human -LRB- CD4 + -RRB- T lymphocytes .
24603895	0	Interleukin-15	0,14	interleukin-15	27,41	Interleukin-15	interleukin-15	3600	3600	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Interleukin-15 and soluble interleukin-15 receptor a in coronary_artery_disease patients : association with epicardial fat and indices of adipose tissue distribution .
9176231	0	Interleukin-15	0,14	interleukin-2	74,87	Interleukin-15	interleukin-2	3600	3558	Gene	Gene	signals|nsubj|START_ENTITY signals|dobj|cells cells|nmod|absence absence|nmod|beta-chain beta-chain|compound|END_ENTITY	Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain .
10594681	0	Interleukin-15	0,14	interleukin-8	33,46	Interleukin-15	interleukin-8	3600	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin-15 strongly inhibits interleukin-8 and monocyte_chemoattractant_protein-1 production in human colonic epithelial cells .
16423044	0	Interleukin-16	0,14	interleukin-13	24,38	Interleukin-16	interleukin-13	3603	3596	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin-16 inhibits interleukin-13 production by allergen-stimulated blood mononuclear cells .
25201147	0	Interleukin-17	0,14	CC_chemokine_receptor_6	23,46	Interleukin-17	CC chemokine receptor 6	3605	1235	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-17 induces CC_chemokine_receptor_6 expression and cell migration in colorectal_cancer cells .
25038765	0	Interleukin-17	0,14	COX-2	88,93	Interleukin-17	COX-2	3605	5743	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	Interleukin-17 Indirectly Promotes M2 Macrophage Differentiation through Stimulation of COX-2 / PGE2 Pathway in the Cancer Cells .
25807214	0	Interleukin-17	0,14	IL-17	16,21	Interleukin-17	IL-17	3605	3605	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Interleukin-17 -LRB- IL-17 -RRB- Inhibitors in the Treatment of Plaque Psoriasis : A Review .
24708416	0	Interleukin-17	0,14	Toll-like_receptor_3	43,63	Interleukin-17	Toll-like receptor 3	3605	7098	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Interleukin-17 increases the expression of Toll-like_receptor_3 via the STAT3 pathway in rheumatoid_arthritis fibroblast-like synoviocytes .
23331180	0	Interleukin-17	0,14	interferon-y	42,54	Interleukin-17	interferon-y	3605	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Interleukin-17 enhances the production of interferon-y and tumour_necrosis_factor-a by bone marrow T lymphocytes from patients with lower risk myelodysplastic_syndromes .
23283206	0	Interleukin-17A	81,96	CCL20	61,66	Interleukin-17A	CCL20	3605	6364	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Synergistic Induction of Macrophage_Inflammatory_Protein-3a ; / CCL20 Production by Interleukin-17A and Tumor_Necrosis_Factor-a ; in Nasal Polyp Fibroblasts .
26830368	0	Interleukin-17A	0,15	IL-1b	24,29	Interleukin-17A	IL-1b	3605	3553	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Interleukin-17A Induces IL-1b Secretion From RPE Cells Via the NLRP3 Inflammasome .
24892823	0	Interleukin-17A	0,15	MUC5AC	25,31	Interleukin-17A	MUC5AC	3605	4586	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Interleukin-17A promotes MUC5AC expression and goblet cell hyperplasia in nasal_polyps via the Act1-mediated pathway .
26830368	0	Interleukin-17A	0,15	NLRP3	63,68	Interleukin-17A	NLRP3	3605	114548	Gene	Gene	Secretion|compound|START_ENTITY Via|nsubj|Secretion Via|dobj|Inflammasome Inflammasome|compound|END_ENTITY	Interleukin-17A Induces IL-1b Secretion From RPE Cells Via the NLRP3 Inflammasome .
20937352	0	Interleukin-17A	0,15	cathepsin_K	24,35	Interleukin-17A	cathepsin K	16171(Tax:10090)	13038(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-17A induces cathepsin_K and MMP-9 expression in osteoclasts via celecoxib-blocked prostaglandin_E2 in osteoblasts .
26733204	0	Interleukin-17A	0,15	p38	118,121	Interleukin-17A	p38	3605	1432	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 MAPK Pathway .
22498566	0	Interleukin-18	0,14	ATP-binding_cassette_transporter_A1	56,91	Interleukin-18	ATP-binding cassette transporter A1	3606	19	Gene	Gene	downregulate|nsubj|START_ENTITY downregulate|dobj|expression expression|compound|END_ENTITY	Interleukin-18 and interleukin-12 together downregulate ATP-binding_cassette_transporter_A1 expression through the interleukin-18R / nuclear factor-kB signaling pathway in THP-1 macrophage-derived foam cells .
24331389	0	Interleukin-18	0,14	CD8	27,30	Interleukin-18	CD8	3606	925	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-18 expression , CD8 -LRB- + -RRB- T cells , and eosinophils in lungs of nonsmokers with fatal asthma .
20693392	0	Interleukin-18	0,14	EMMPRIN	112,119	Interleukin-18	EMMPRIN	3606	682	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|part part|nmod|END_ENTITY	Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation .
20693392	0	Interleukin-18	0,14	EMMPRIN	23,30	Interleukin-18	EMMPRIN	3606	682	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation .
10714558	0	Interleukin-18	0,14	IL-2	35,39	Interleukin-18	IL-2	16173(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Interleukin-18 in combination with IL-2 enhances natural killer cell activity without inducing large amounts of IFN-gamma in vivo .
11221875	0	Interleukin-18	0,14	IL-2	39,43	Interleukin-18	IL-2	3606	3558	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Interleukin-18 -LRB- IL-18 -RRB- synergizes with IL-2 to enhance cytotoxicity , interferon-gamma production , and expansion of natural killer cells .
19229765	0	Interleukin-18	0,14	IL18	21,25	Interleukin-18	IL18	3606	3606	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin-18 gene -LRB- IL18 -RRB- promoter polymorphisms in patients with rheumatoid_arthritis .
26292095	0	Interleukin-18	0,14	Multidrug_Resistance-Associated_Protein_2	30,71	Interleukin-18	Multidrug Resistance-Associated Protein 2	3606	1244	Gene	Gene	Down-Regulates|compound|START_ENTITY END_ENTITY|nsubj|Down-Regulates	Interleukin-18 Down-Regulates Multidrug_Resistance-Associated_Protein_2 Expression through Farnesoid_X_Receptor Associated with Nuclear Factor Kappa B and Yin_Yang_1 in Human Hepatoma HepG2 Cells .
26292095	0	Interleukin-18	0,14	Multidrug_Resistance-Associated_Protein_2	30,71	Interleukin-18	Multidrug Resistance-Associated Protein 2	3606	1244	Gene	Gene	Down-Regulates|compound|START_ENTITY END_ENTITY|nsubj|Down-Regulates	Interleukin-18 Down-Regulates Multidrug_Resistance-Associated_Protein_2 Expression through Farnesoid_X_Receptor Associated with Nuclear Factor Kappa B and Yin_Yang_1 in Human Hepatoma HepG2 Cells .
17308068	0	Interleukin-18	0,14	T-bet	34,39	Interleukin-18	T-bet	3606	30009	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-kappaB in acute_myeloid_leukemia-derived predendritic KG-1 cells .
11170988	0	Interleukin-18	14,28	Th1	32,35	Interleukin-18	Th1	3606	51497	Gene	Gene	START_ENTITY|appos|cytokine cytokine|amod|END_ENTITY	Expression of Interleukin-18 , a Th1 cytokine , in human gastric mucosa is increased in Helicobacter_pylori_infection .
11244043	0	Interleukin-18	0,14	Th1	30,33	Interleukin-18	Th1	3606	51497	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Interleukin-18 regulates both Th1 and Th2 responses .
18538609	0	Interleukin-18	0,14	Th2	26,29	Interleukin-18	Th2	16173(Tax:10090)	15111(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice .
18086672	0	Interleukin-18	0,14	adiponectin	26,37	Interleukin-18	adiponectin	3606	9370	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation .
10486154	0	Interleukin-18	0,14	interferon-gamma	23,39	Interleukin-18	interferon-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells .
11834721	0	Interleukin-18	0,14	interferon-gamma	89,105	Interleukin-18	interferon-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|release release|nmod|END_ENTITY	Interleukin-18 enhances atherosclerosis in apolipoprotein_E -LRB- - / - -RRB- mice through release of interferon-gamma .
14640238	0	Interleukin-18	0,14	interferon-gamma	74,90	Interleukin-18	interferon-gamma	3606	3458	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Interleukin-18 , interleukin-18_binding_protein and impaired production of interferon-gamma in chronic renal_failure .
15162834	0	Interleukin-18	0,14	interferon-gamma	42,58	Interleukin-18	interferon-gamma	3606	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Interleukin-18 enhances the production of interferon-gamma -LRB- IFN-gamma -RRB- by allergen-specific and unspecific stimulated cord blood mononuclear cells .
9815245	0	Interleukin-18	0,14	interferon-gamma	51,67	Interleukin-18	interferon-gamma	3606	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures .
9490698	0	Interleukin-18	0,14	interferon_gamma	29,45	Interleukin-18	interferon gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|production production|amod|END_ENTITY	Interleukin-18 regulation of interferon_gamma production and cell proliferation as shown in interleukin-1beta-converting_enzyme -LRB- caspase-1 -RRB- - deficient mice .
16115484	0	Interleukin-18	0,14	interleukin-10	16,30	Interleukin-18	interleukin-10	3606	3586	Gene	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	Interleukin-18 : interleukin-10 ratio and in-hospital adverse events in patients with acute_coronary_syndrome .
11298325	0	Interleukin-18	0,14	interleukin-8	42,55	Interleukin-18	interleukin-8	3606	3576	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Interleukin-18 enhances the production of interleukin-8 by eosinophils .
9266843	0	Interleukin-18	0,14	p56	53,56	Interleukin-18	p56	16173(Tax:10090)	15957(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Interleukin-18 induces activation and association of p56 -LRB- lck -RRB- and MAPK in a murine TH1 clone .
18165223	0	Interleukin-18	0,14	parathyroid_hormone	31,50	Interleukin-18	parathyroid hormone	29197(Tax:10116)	24694(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Interleukin-18 is regulated by parathyroid_hormone and is required for its bone anabolic actions .
19535202	0	Interleukin-18	0,14	transferrin	23,34	Interleukin-18	transferrin	3606	7018	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-18 induces transferrin expression in breast_cancer cell line MCF-7 .
14872485	0	Interleukin-18	0,14	tumor_necrosis_factor_alpha	33,60	Interleukin-18	tumor necrosis factor alpha	3606	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Interleukin-18 enhances monocyte tumor_necrosis_factor_alpha and interleukin-1beta production induced by direct contact with T lymphocytes : implications in rheumatoid_arthritis .
16368150	0	Interleukin-18	0,14	vascular_endothelial_growth_factor	41,75	Interleukin-18	vascular endothelial growth factor	3606	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Interleukin-18 induces the production of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts via AP-1-dependent pathways .
22158875	0	Interleukin-19	0,14	heme_oxygenase-1	31,47	Interleukin-19	heme oxygenase-1	29949	3162	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-19 -LRB- IL-19 -RRB- induces heme_oxygenase-1 -LRB- HO-1 -RRB- expression and decreases reactive oxygen species in human vascular smooth muscle cells .
16120148	0	Interleukin-19	0,14	keratinocyte_growth_factor	27,53	Interleukin-19	keratinocyte growth factor	29949	2252	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Interleukin-19 upregulates keratinocyte_growth_factor and is associated with psoriasis .
9858899	0	Interleukin-1_alpha	0,19	CAPL	187,191	Interleukin-1 alpha	CAPL	3552	6275	Gene	Gene	modulated|nsubjpass|START_ENTITY modulated|nmod|END_ENTITY	Interleukin-1_alpha and basic fibroblast growth factor induction of matrix metalloproteinases and their inhibitors in osteosarcoma cells is modulated by the metastasis_associated_protein CAPL .
1429687	0	Interleukin-1_alpha	0,19	cytosolic_phospholipase_A2	48,74	Interleukin-1 alpha	cytosolic phospholipase A2	3552	5321	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|accumulation accumulation|nmod|END_ENTITY	Interleukin-1_alpha induces the accumulation of cytosolic_phospholipase_A2 and the release of prostaglandin_E2 in human fibroblasts .
1695108	0	Interleukin-1_alpha	0,19	granulocyte-macrophage_colony-stimulating_factor	33,81	Interleukin-1 alpha	granulocyte-macrophage colony-stimulating factor	3552	1437	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin-1_alpha also induces granulocyte-macrophage_colony-stimulating_factor in immature normal bone marrow cells .
21816944	0	Interleukin-1_alpha	0,19	intercellular_adhesion_molecule-1	93,126	Interleukin-1 alpha	intercellular adhesion molecule-1	3552	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1_alpha produced by human T-cell_leukaemia_virus_type_I-infected T cells induces intercellular_adhesion_molecule-1 expression on lung epithelial cells .
8725537	0	Interleukin-1_alpha	0,19	interleukin-1_beta	21,39	Interleukin-1 alpha	interleukin-1 beta	3552	3553	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Interleukin-1_alpha , interleukin-1_beta and interleukin-8 gene expression in human aural_cholesteatomas .
8915952	0	Interleukin-1_alpha	0,19	interleukin-8	21,34	Interleukin-1 alpha	interleukin-8	3552	3576	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Interleukin-1_alpha , interleukin-8 and interferon-alpha levels in gingival crevicular fluid .
8996657	0	Interleukin-1_alpha	0,19	surfactant_protein-A	50,70	Interleukin-1 alpha	surfactant protein-A	100009250(Tax:9986)	100009044(Tax:9986)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-1_alpha upregulates the expression of surfactant_protein-A in rabbit lung explants .
1774433	0	Interleukin-1_alpha	0,19	tumor_necrosis_factor-alpha	47,74	Interleukin-1 alpha	tumor necrosis factor-alpha	16175(Tax:10090)	21926(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|hepatotoxicity hepatotoxicity|nmod|END_ENTITY	Interleukin-1_alpha enhances hepatotoxicity of tumor_necrosis_factor-alpha in galactosamine-sensitized mice .
7505212	0	Interleukin-1_and_B7	0,20	CD28	21,25	Interleukin-1 and B7	CD28	3552	940	Gene	Gene	START_ENTITY|parataxis|interaction interaction|nsubj|END_ENTITY	Interleukin-1_and_B7 / CD28 interaction regulate interleukin-6 production by human T cells .
12727445	0	Interleukin-1_beta	0,18	Akt	83,86	Interleukin-1 beta	Akt	3553	207	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Interleukin-1_beta protects neurons via the interleukin-1 -LRB- IL-1 -RRB- receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo .
1536949	0	Interleukin-1_beta	0,18	IL-1_beta	20,29	Interleukin-1 beta	IL-1 beta	3553	3553	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , M-CSF , and IL-3 .
1732310	0	Interleukin-1_beta	0,18	IL-1_beta	20,29	Interleukin-1 beta	IL-1 beta	3553	3553	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- levels in gingival crevicular fluid from adults with previous evidence of destructive_periodontitis .
18021299	0	Interleukin-1_beta	0,18	TACE	32,36	Interleukin-1 beta	TACE	3553	6868	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Interleukin-1_beta up-regulates TACE to enhance alpha-cleavage of APP in neurons : resulting decrease in Abeta production .
7615646	0	Interleukin-1_beta	0,18	TIMP-1	71,77	Interleukin-1 beta	TIMP-1	3553	7076	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Interleukin-1_beta induction of tissue inhibitor of metalloproteinase -LRB- TIMP-1 -RRB- is functionally antagonized by prostaglandin_E2 in human synovial fibroblasts .
1639861	0	Interleukin-1_beta	0,18	TNF-alpha	32,41	Interleukin-1 beta	TNF-alpha	3553	7124	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Interleukin-1_beta induction of TNF-alpha gene expression : involvement of protein_kinase_C .
8863511	0	Interleukin-1_beta	0,18	alpha_1-antichymotrypsin	72,96	Interleukin-1 beta	alpha 1-antichymotrypsin	3553	12	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Interleukin-1_beta and tumor_necrosis_factor-alpha induce expression of alpha_1-antichymotrypsin in human astrocytoma cells by activation of nuclear_factor-kappa_B .
8348296	0	Interleukin-1_beta	0,18	c-fos	72,77	Interleukin-1 beta	c-fos	24494(Tax:10116)	314322(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Interleukin-1_beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat .
1381374	0	Interleukin-1_beta	0,18	colony-stimulating_factor-1	30,57	Interleukin-1 beta	colony-stimulating factor-1	3553	1435	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Interleukin-1_beta stimulates colony-stimulating_factor-1 production in placental villous core mesenchymal cells .
1517398	0	Interleukin-1_beta	0,18	corticotropin-releasing_factor-41	27,60	Interleukin-1 beta	corticotropin-releasing factor-41	24494(Tax:10116)	81648(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Interleukin-1_beta induces corticotropin-releasing_factor-41 release from cultured hypothalamic cells through protein kinase C and cAMP-dependent protein kinase pathways .
10533051	0	Interleukin-1_beta	0,18	cyclooxygenase-2	194,210	Interleukin-1 beta	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|platelet-activating_factor platelet-activating_factor|nmod|mediator mediator|nmod|expression expression|amod|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
10533051	0	Interleukin-1_beta	0,18	cyclooxygenase-2	43,59	Interleukin-1 beta	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
21683339	0	Interleukin-1_beta	0,18	cyclooxygenase-2	27,43	Interleukin-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Interleukin-1_beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle .
8526991	0	Interleukin-1_beta	0,18	cyclooxygenase-2	27,43	Interleukin-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Interleukin-1_beta induces cyclooxygenase-2 in cultured human decidual cells .
8543370	0	Interleukin-1_beta	0,18	cyclooxygenase-2	41,57	Interleukin-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Interleukin-1_beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts .
8632179	0	Interleukin-1_beta	0,18	cyclooxygenase-2	57,73	Interleukin-1 beta	cyclooxygenase-2	16176(Tax:10090)	19225(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|prostaglandin_G prostaglandin_G|dobj|H H|dep|END_ENTITY	Interleukin-1_beta induces prostaglandin_G / H synthase-2 -LRB- cyclooxygenase-2 -RRB- in primary murine astrocyte cultures .
9467571	0	Interleukin-1_beta	0,18	cyclooxygenase-2	27,43	Interleukin-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1_beta induces cyclooxygenase-2 gene expression in cultured endometrial stromal cells .
8273584	0	Interleukin-1_beta	0,18	cytosolic_PLA2	27,41	Interleukin-1 beta	cytosolic PLA2	3553	5321	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin-1_beta induces cytosolic_PLA2 in parallel with prostaglandin_E2 in rheumatoid synovial fibroblasts .
7480804	0	Interleukin-1_beta	0,18	cytosolic_phospholipase_A2	57,83	Interleukin-1 beta	cytosolic phospholipase A2	3553	5321	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Interleukin-1_beta induces the synthesis and activity of cytosolic_phospholipase_A2 and the release of prostaglandin_E2 in human amnion-derived WISH cells .
2199215	0	Interleukin-1_beta	0,18	glucokinase	28,39	Interleukin-1 beta	glucokinase	3553	2645	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Interleukin-1_beta inhibits glucokinase activity in clonal HIT-T15 beta-cells .
1536949	0	Interleukin-1_beta	0,18	granulocyte-macrophage_colony-stimulating_factor	111,159	Interleukin-1 beta	granulocyte-macrophage colony-stimulating factor	3553	1437	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , M-CSF , and IL-3 .
8639772	0	Interleukin-1_beta	0,18	granulocyte_colony-stimulating_factor	41,78	Interleukin-1 beta	granulocyte colony-stimulating factor	3553	1440	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Interleukin-1_beta induces production of granulocyte_colony-stimulating_factor in human hepatoma cells .
8796827	0	Interleukin-1_beta	0,18	granulocyte_colony-stimulating_factor	61,98	Interleukin-1 beta	granulocyte colony-stimulating factor	3553	1440	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|production production|amod|END_ENTITY	Interleukin-1_beta and tumor_necrosis_factor-alpha stimulate granulocyte_colony-stimulating_factor production by placental villous core mesenchymal cells .
1954872	0	Interleukin-1_beta	0,18	interleukin-1_alpha	27,46	Interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1_beta induces interleukin-1_alpha messenger ribonucleic acid expression in primary cultures of Leydig cells .
2506855	0	Interleukin-1_beta	0,18	interleukin-1_alpha	39,58	Interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	potent|nsubj|START_ENTITY potent|advcl|END_ENTITY	Interleukin-1_beta is more potent than interleukin-1_alpha in suppressing follicle-stimulating hormone-induced differentiation_of_ovarian_granulosa cells .
9168406	0	Interleukin-1_beta	0,18	interleukin-1_receptor_type_II	67,97	Interleukin-1 beta	interleukin-1 receptor type II	3553	7850	Gene	Gene	START_ENTITY|appos|secretion secretion|amod|END_ENTITY	Interleukin-1_beta , interleukin-1_receptor_antagonist , and soluble interleukin-1_receptor_type_II secretion in chronic_fatigue_syndrome .
11197112	0	Interleukin-1_beta	0,18	interleukin-5	20,33	Interleukin-1 beta	interleukin-5	3553	3567	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Interleukin-1_beta , interleukin-5 , interleukin-6 , interleukin-8 , and tumor_necrosis_factor-alpha in chronic sinusitis : response to systemic corticosteroids .
11197112	0	Interleukin-1_beta	0,18	interleukin-6	35,48	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Interleukin-1_beta , interleukin-5 , interleukin-6 , interleukin-8 , and tumor_necrosis_factor-alpha in chronic sinusitis : response to systemic corticosteroids .
12190816	0	Interleukin-1_beta	0,18	interleukin-6	27,40	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1_beta induces interleukin-6 mRNA expression and protein production in synovial cells from human temporomandibular_joint .
2335234	0	Interleukin-1_beta	0,18	interleukin-6	54,67	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Interleukin-1_beta induces synthesis and secretion of interleukin-6 in human chondrocytes .
7700568	0	Interleukin-1_beta	0,18	interleukin-6	20,33	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	elevated|advmod|START_ENTITY elevated|nsubj|END_ENTITY	Interleukin-1_beta , interleukin-6 , epidermal_growth_factor and transforming_growth_factor-alpha are elevated in the brain from parkinsonian patients .
7711382	0	Interleukin-1_beta	0,18	interleukin-6	20,33	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Interleukin-1_beta , interleukin-6 , and growth_hormone levels in human follicular fluid .
8024037	0	Interleukin-1_beta	0,18	interleukin-6	64,77	Interleukin-1 beta	interleukin-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	causes|nsubj|START_ENTITY causes|dobj|increase increase|nmod|anterior anterior|amod|END_ENTITY	Interleukin-1_beta causes the increase in anterior hypothalamic interleukin-6 during LPS-induced fever in rats .
8275959	0	Interleukin-1_beta	0,18	interleukin-6	30,43	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Interleukin-1_beta stimulates interleukin-6 production in placental villous core mesenchymal cells .
8627304	0	Interleukin-1_beta	0,18	interleukin-6	84,97	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	uses|nsubj|START_ENTITY uses|xcomp|signaling signaling|nmod|induction induction|nmod|genes genes|amod|END_ENTITY	Interleukin-1_beta uses common and distinct signaling pathways for induction of the interleukin-6 and tumor_necrosis_factor_alpha genes in the human astrocytoma cell line U373 .
8964907	0	Interleukin-1_beta	0,18	interleukin-6	42,55	Interleukin-1 beta	interleukin-6	704701(Tax:9544)	705819(Tax:9544)	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|interleukin-6_receptor interleukin-6_receptor|amod|END_ENTITY	Interleukin-1_beta differentially affects interleukin-6 and soluble interleukin-6_receptor in the blood and central nervous system of the monkey .
9329125	0	Interleukin-1_beta	0,18	interleukin-6	49,62	Interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|production production|amod|END_ENTITY	Interleukin-1_beta and interferon-gamma regulate interleukin-6 production in cultured human intestinal epithelial cells .
11705672	0	Interleukin-1_beta	0,18	nerve_growth_factor	49,68	Interleukin-1 beta	nerve growth factor	24494(Tax:10116)	310738(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|secretion secretion|compound|END_ENTITY	Interleukin-1_beta , but not IL-1_alpha , mediates nerve_growth_factor secretion from rat astrocytes via type I IL-1 receptor .
1951711	0	Interleukin-1_beta	0,18	nerve_growth_factor	77,96	Interleukin-1 beta	nerve growth factor	24494(Tax:10116)	310738(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|synthesis synthesis|compound|END_ENTITY	Interleukin-1_beta and tumor_necrosis_factor-alpha synergistically stimulate nerve_growth_factor synthesis in rat mesangial cells .
10735599	0	Interleukin-1_beta	0,18	oxytocin_receptor	38,55	Interleukin-1 beta	oxytocin receptor	3553	5021	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Interleukin-1_beta down-regulates the oxytocin_receptor in cultured uterine smooth muscle cells .
1575744	0	Interleukin-1_beta	0,18	phospholipase_A2	40,56	Interleukin-1 beta	phospholipase A2	3553	151056	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Interleukin-1_beta stimulates cytosolic phospholipase_A2 in rheumatoid synovial fibroblasts .
2803314	0	Interleukin-1_beta	0,18	phospholipase_A2	30,46	Interleukin-1 beta	phospholipase A2	100008990(Tax:9986)	151056	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|amod|END_ENTITY	Interleukin-1_beta stimulates phospholipase_A2 mRNA synthesis in rabbit articular chondrocytes .
8185692	0	Interleukin-1_beta	0,18	phospholipase_A2	37,53	Interleukin-1 beta	phospholipase A2	3553	151056	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin-1_beta induces cytosolic phospholipase_A2 and prostaglandin_H synthase in rheumatoid synovial fibroblasts .
10533051	0	Interleukin-1_beta	0,18	platelet-activating_factor	137,163	Interleukin-1 beta	platelet-activating factor	24494(Tax:10116)	300795(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
1478730	0	Interleukin-1_beta	0,18	proenkephalin	29,42	Interleukin-1 beta	proenkephalin	24494(Tax:10116)	29237(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Interleukin-1_beta regulates proenkephalin gene expression in astrocytes cultured from rat cortex .
25418470	0	Interleukin-1_beta	0,18	stem_cell_factor	60,76	Interleukin-1 beta	stem cell factor	3553	4254	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin-1_beta induces the expression and production of stem_cell_factor by epithelial cells : crucial involvement of the PI-3K / mTOR pathway and HIF-1 transcription complex .
8874752	0	Interleukin-1_beta	0,18	tissue-type_plasminogen_activator	31,64	Interleukin-1 beta	tissue-type plasminogen activator	3553	5327	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Interleukin-1_beta upregulates tissue-type_plasminogen_activator in a keratinocyte cell line -LRB- HaCaT -RRB- .
12845752	0	Interleukin-1_beta	0,18	tumor_necrosis_factor-alpha	20,47	Interleukin-1 beta	tumor necrosis factor-alpha	281251(Tax:9913)	280943(Tax:9913)	Gene	Gene	induce|advmod|START_ENTITY induce|nsubj|END_ENTITY	Interleukin-1_beta , tumor_necrosis_factor-alpha and lipopolysaccharide induce expression of monocyte_chemoattractant_protein-1 in calf aortic smooth muscle cells .
1732280	0	Interleukin-1_beta	0,18	tumor_necrosis_factor-alpha	32,59	Interleukin-1 beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Interleukin-1_beta induction of tumor_necrosis_factor-alpha gene expression in human astroglioma cells .
8796819	0	Interleukin-1_beta	0,18	tumor_necrosis_factor-alpha	51,78	Interleukin-1 beta	tumor necrosis factor-alpha	704701(Tax:9544)	715467(Tax:9544)	Gene	Gene	infusion|amod|START_ENTITY induces|nsubj|infusion induces|dobj|END_ENTITY	Interleukin-1_beta intra-amniotic infusion induces tumor_necrosis_factor-alpha , prostaglandin production , and preterm contractions in pregnant rhesus_monkeys .
15050606	0	Interleukin-1_beta	0,18	tumor_necrosis_factor_alpha	38,65	Interleukin-1 beta	tumor necrosis factor alpha	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1_beta -LRB- IL-1beta -RRB- induces tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation .
10198191	0	Interleukin-1_beta	0,18	vascular_endothelial_growth_factor	53,87	Interleukin-1 beta	vascular endothelial growth factor	3553	7422	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-1_beta upregulates cardiac expression of vascular_endothelial_growth_factor and its receptor KDR/flk -1 via activation of protein tyrosine kinases .
7945810	0	Interleukin-1_receptor_antagonist	0,33	IL-1ra	35,41	Interleukin-1 receptor antagonist	IL-1ra	3557	3557	Gene	Gene	production|nummod|START_ENTITY production|compound|END_ENTITY	Interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- production by human amnion , chorion , and decidua .
17321000	0	Interleukin-1_receptor_antagonist	4,37	PPARalpha	65,74	Interleukin-1 receptor antagonist	PPARalpha	3557	5465	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	The Interleukin-1_receptor_antagonist is a direct target gene of PPARalpha in liver .
10460756	0	Interleukin-1_receptor_antagonist	0,33	interleukin-8	43,56	Interleukin-1 receptor antagonist	interleukin-8	3557	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Interleukin-1_receptor_antagonist inhibits interleukin-8 expression in A549 respiratory epithelial cells infected in vitro with a replication-deficient recombinant adenovirus vector .
16006751	0	Interleukin-1_receptor_antagonist	0,33	vascular_endothelial_growth_factor	61,95	Interleukin-1 receptor antagonist	vascular endothelial growth factor	3557	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Interleukin-1_receptor_antagonist inhibits the expression of vascular_endothelial_growth_factor in colorectal_carcinoma .
18332090	0	Interleukin-1_receptor_antagonist_gene	0,38	IL-1RN	40,46	Interleukin-1 receptor antagonist gene	IL-1RN	3557	3557	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Interleukin-1_receptor_antagonist_gene -LRB- IL-1RN -RRB- polymorphism is a predictive factor of clinical pregnancy after IVF .
8332913	0	Interleukin-1_type_II_receptor	0,30	IL-1	51,55	Interleukin-1 type II receptor	IL-1	7850	3552	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	Interleukin-1_type_II_receptor : a decoy target for IL-1 that is regulated by IL-4 .
9056477	0	Interleukin-1alpha	0,18	Thy-1	29,34	Interleukin-1alpha	Thy-1	24493(Tax:10116)	24832(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Interleukin-1alpha regulates Thy-1 expression on rat vascular endothelial cells .
9811056	0	Interleukin-1alpha	0,18	interleukin-11	118,132	Interleukin-1alpha	interleukin-11	3552	3589	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|production production|nmod|END_ENTITY	Interleukin-1alpha and tumor_necrosis_factor_alpha synergistically stimulate prostaglandin_E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts .
16635168	0	Interleukin-1alpha	0,18	interleukin-6_and_tumor_necrosis_factor-alpha	20,65	Interleukin-1alpha	interleukin-6 and tumor necrosis factor-alpha	3552	3569;7124	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Interleukin-1alpha , interleukin-6_and_tumor_necrosis_factor-alpha levels in children with sepsis and meningitis .
12580761	0	Interleukin-1alpha	0,18	steroidogenic_acute_regulatory	30,60	Interleukin-1alpha	steroidogenic acute regulatory	24493(Tax:10116)	25557(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Interleukin-1alpha stimulates steroidogenic_acute_regulatory protein expression via p38 MAP kinase in immature rat Leydig cells .
26069075	0	Interleukin-1b	0,14	Angptl4	25,32	Interleukin-1b	Angptl4	16176(Tax:10090)	57875(Tax:10090)	Gene	Gene	START_ENTITY|dobj|Expression Expression|compound|END_ENTITY	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
27086348	0	Interleukin-1b	0,14	Ank	48,51	Interleukin-1b	Ank	3553	286	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|END_ENTITY	Interleukin-1b Suppresses the Transporter Genes Ank and Ent1 Expression in Stromal Progenitor Cells Retaining Mineralization .
27086348	0	Interleukin-1b	0,14	Ank	48,51	Interleukin-1b	Ank	3553	286	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|END_ENTITY	Interleukin-1b Suppresses the Transporter Genes Ank and Ent1 Expression in Stromal Progenitor Cells Retaining Mineralization .
26473326	0	Interleukin-1b	79,93	CREB	52,56	Interleukin-1b	CREB	24494(Tax:10116)	81646(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Long-Lasting Activation of the Transcription Factor CREB in Sensory Neurons by Interleukin-1b During Antigen-Induced Arthritis in Rats : A Mechanism of Persistent Arthritis Pain ?
20596246	0	Interleukin-1b	92,106	Caspase-1	68,77	Interleukin-1b	Caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Ac-YVAD-CMK Decreases Blood-Brain Barrier Degradation by Inhibiting Caspase-1 Activation of Interleukin-1b in Intracerebral_Hemorrhage Mouse Model .
25091703	0	Interleukin-1b	0,14	ERK	136,139	Interleukin-1b	ERK	3553	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|parataxis|activation activation|nmod|END_ENTITY	Interleukin-1b promotes the LC3-mediated secretory function of osteoclast precursors by stimulating the Ca - dependent activation of ERK .
26858639	0	Interleukin-1b	56,70	ERK	121,124	Interleukin-1b	ERK	3553	5594	Gene	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Thromboxane_A2 Receptor Stimulation Enhances Microglial Interleukin-1b and NO_Biosynthesis Mediated by the Activation of ERK Pathway .
26069075	0	Interleukin-1b	0,14	FIAF	34,38	Interleukin-1b	FIAF	16176(Tax:10090)	57875(Tax:10090)	Gene	Gene	START_ENTITY|dobj|Expression Expression|appos|END_ENTITY	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
22302133	0	Interleukin-1b	0,14	MICA	50,54	Interleukin-1b	MICA	3553	100507436	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Interleukin-1b enhances the production of soluble MICA in human hepatocellular_carcinoma .
21183380	0	Interleukin-1b	0,14	NLRP3	82,87	Interleukin-1b	NLRP3	3553	114548	Gene	Gene	activation|amod|START_ENTITY activation|dep|role role|nmod|inflammasome inflammasome|compound|END_ENTITY	Interleukin-1b activation during acute_joint_inflammation : a limited role for the NLRP3 inflammasome in vivo .
25548278	0	Interleukin-1b	112,126	NLRP3	0,5	Interleukin-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	Independent|nmod|START_ENTITY Exacerbates|nmod|Independent Exacerbates|nsubj|Protein_Deficiency Protein_Deficiency|compound|END_ENTITY	NLRP3 Protein_Deficiency Exacerbates Hyperoxia-induced Lethality through Stat3 Protein Signaling Independent of Interleukin-1b .
26502906	0	Interleukin-1b	108,122	NLRP3	26,31	Interleukin-1b	NLRP3	3553	114548	Gene	Gene	Production|nmod|START_ENTITY Promote|dobj|Production Activate|xcomp|Promote Activate|dobj|Pathway Pathway|compound|END_ENTITY	Shiga Toxins Activate the NLRP3 Inflammasome Pathway to Promote both Production of Proinflammatory Cytokine Interleukin-1b and Apoptotic Cell Death .
25548278	0	Interleukin-1b	112,126	Stat3	73,78	Interleukin-1b	Stat3	16176(Tax:10090)	20848(Tax:10090)	Gene	Gene	Independent|nmod|START_ENTITY Independent|compound|END_ENTITY	NLRP3 Protein_Deficiency Exacerbates Hyperoxia-induced Lethality through Stat3 Protein Signaling Independent of Interleukin-1b .
21762900	0	Interleukin-1b	0,14	cyclooxygenase-2	23,39	Interleukin-1b	cyclooxygenase-2	3553	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1b induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian_endometrioma .
26811540	0	Interleukin-1b	0,14	fibroblast_growth_factor_2	23,49	Interleukin-1b	fibroblast growth factor 2	16176(Tax:10090)	14173(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1b induces fibroblast_growth_factor_2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes .
20801015	0	Interleukin-1b	0,14	hypoxia-inducible_factor-1a	93,120	Interleukin-1b	hypoxia-inducible factor-1a	3553	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Interleukin-1b regulates the migratory potential of MDAMB231 breast_cancer cells through the hypoxia-inducible_factor-1a .
24330727	0	Interleukin-1b	0,14	hypoxia_inducible_factor_2a	26,53	Interleukin-1b	hypoxia inducible factor 2a	3553	2034	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	Interleukin-1b sequesters hypoxia_inducible_factor_2a to the primary cilium .
24126863	0	Interleukin-1b	0,14	matrix_metalloproteinase-13	27,54	Interleukin-1b	matrix metalloproteinase-13	24494(Tax:10116)	171052(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Interleukin-1b upregulates matrix_metalloproteinase-13 gene expression via c-Jun_N-terminal_kinase and p38 MAPK pathways in rat hepatic stellate cells .
22888172	0	Interleukin-1b	0,14	thymic_stromal_lymphopoietin	43,71	Interleukin-1b	thymic stromal lymphopoietin	3553	85480	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Interleukin-1b stimulates the secretion of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- from endometrioma stromal cells : possible involvement of TSLP in endometriosis .
23647831	0	Interleukin-1b	0,14	tumor_necrosis_factor-a	23,46	Interleukin-1b	tumor necrosis factor-a	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Interleukin-1b induces tumor_necrosis_factor-a secretion from rat hepatocytes .
9614202	0	Interleukin-1beta	0,17	B2_receptor	37,48	Interleukin-1beta	B2 receptor	3553	624	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta induces bradykinin B2_receptor gene expression through a prostanoid cyclic_AMP-dependent pathway in human bronchial smooth muscle cells .
10657593	0	Interleukin-1beta	0,17	CFTR	28,32	Interleukin-1beta	CFTR	3553	1080	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta regulates CFTR expression in human intestinal T84 cells .
15950780	0	Interleukin-1beta	0,17	CREB-binding_protein	26,46	Interleukin-1beta	CREB-binding protein	24494(Tax:10116)	54244(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|amod|END_ENTITY	Interleukin-1beta induces CREB-binding_protein -LRB- CBP -RRB- mRNA in brain and the sequencing of rat CBP .
17027275	0	Interleukin-1beta	0,17	GDNF	27,31	Interleukin-1beta	GDNF	3553	2668	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Interleukin-1beta mediates GDNF up-regulation upon dopaminergic injury in ventral midbrain cell cultures .
12688541	0	Interleukin-1beta	34,51	Growth_hormone	0,14	Interleukin-1beta	Growth hormone	3553	2688	Gene	Gene	expression|amod|START_ENTITY down-regulation|nmod|expression down-regulation|amod|END_ENTITY	Growth_hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute_phase_protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3 .
20432452	0	Interleukin-1beta	0,17	ICAM-1	26,32	Interleukin-1beta	ICAM-1	3553	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid_arthritis synovial fibroblasts : involvement of ERK , JNK , AP-1 , and NF-kappaB .
10498857	0	Interleukin-1beta	0,17	IL-1beta	19,27	Interleukin-1beta	IL-1beta	24494(Tax:10116)	24494(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Interleukin-1beta -LRB- IL-1beta -RRB- inhibition : a possible mechanism for the anti-inflammatory potency of liposomally conjugated methotrexate formulations in arthritis .
15208668	0	Interleukin-1beta	0,17	IL-8	29,33	Interleukin-1beta	IL-8	3553	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric_carcinoma cells .
17184847	0	Interleukin-1beta	53,70	Interleukin-6	154,167	Interleukin-1beta	Interleukin-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|acl|infected infected|nmod|effect effect|nmod|level level|nmod|END_ENTITY	Interleukin-10 reduces hyperalgesia and the level of Interleukin-1beta in BALB/c mice infected with Leishmania_major with no major effect on the level of Interleukin-6 .
10547161	0	Interleukin-1beta	0,17	MMP-9	30,35	Interleukin-1beta	MMP-9	3553	4318	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant_cell_tumor_of_bone .
17311279	0	Interleukin-1beta	0,17	MMP-9	26,31	Interleukin-1beta	MMP-9	3553	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK , p38 MAPK , JNK , and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells .
12391274	0	Interleukin-1beta	0,17	MUC2	26,30	Interleukin-1beta	MUC2	3553	4583	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|compound|END_ENTITY	Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells .
12482999	0	Interleukin-1beta	0,17	MUC2	26,30	Interleukin-1beta	MUC2	3553	4583	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells .
16286467	0	Interleukin-1beta	0,17	NFkappaB	31,39	Interleukin-1beta	NFkappaB	3553	4790	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase .
18262272	0	Interleukin-1beta	0,17	NFkappaB	98,106	Interleukin-1beta	NFkappaB	3553	4790	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|inducing inducing|dobj|END_ENTITY	Interleukin-1beta stimulates acute phase response and C-reactive_protein synthesis by inducing an NFkappaB - and C/EBPbeta-dependent autocrine interleukin-6 loop .
15390113	0	Interleukin-1beta	0,17	NK-1R	78,83	Interleukin-1beta	NK-1R	3553	6869	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-1beta upregulates functional expression of neurokinin-1_receptor -LRB- NK-1R -RRB- via NF-kappaB in astrocytes .
15482330	0	Interleukin-1beta	0,17	RANTES	28,34	Interleukin-1beta	RANTES	3553	6352	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Interleukin-1beta increases RANTES gene expression and production in synovial fibroblasts from human temporomandibular_joint .
18260825	0	Interleukin-1beta	0,17	RGS4	31,35	Interleukin-1beta	RGS4	100008990(Tax:9986)	100009014(Tax:9986)	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle .
9923604	0	Interleukin-1beta	0,17	STAT-3	36,42	Interleukin-1beta	STAT-3	3553	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|isoform isoform|compound|END_ENTITY	Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells .
18163503	0	Interleukin-1beta	0,17	Smad7	35,40	Interleukin-1beta	Smad7	3553	4092	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Interleukin-1beta up-regulation of Smad7 via NF-kappaB activation in human chondrocytes .
9570721	0	Interleukin-1beta	0,17	TGF-beta1	115,124	Interleukin-1beta	TGF-beta1	24494(Tax:10116)	59086(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Interleukin-1beta system -LRB- ligand , receptor type I , receptor accessory protein and receptor antagonist -RRB- , TNF-alpha , TGF-beta1 and neuropeptide_Y mRNAs in specific brain regions during bacterial LPS-induced anorexia .
9570721	0	Interleukin-1beta	0,17	TNF-alpha	104,113	Interleukin-1beta	TNF-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Interleukin-1beta system -LRB- ligand , receptor type I , receptor accessory protein and receptor antagonist -RRB- , TNF-alpha , TGF-beta1 and neuropeptide_Y mRNAs in specific brain regions during bacterial LPS-induced anorexia .
12967645	0	Interleukin-1beta	0,17	UCP-2	41,46	Interleukin-1beta	UCP-2	24494(Tax:10116)	54315(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|mRNA mRNA|compound|END_ENTITY	Interleukin-1beta swiftly down-regulates UCP-2 mRNA in beta-cells by mechanisms not directly coupled to toxicity .
19179618	0	Interleukin-1beta	0,17	Zip14	115,120	Interleukin-1beta	Zip14	16176(Tax:10090)	213053(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Interleukin-1beta contributes via nitric_oxide to the upregulation and functional activity of the zinc transporter Zip14 -LRB- Slc39a14 -RRB- in murine hepatocytes .
12688541	0	Interleukin-1beta	34,51	acute_phase_protein	78,97	Interleukin-1beta	acute phase protein	3553	351	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Growth_hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute_phase_protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3 .
19317852	0	Interleukin-1beta	0,17	amyloid_precursor_protein	76,101	Interleukin-1beta	amyloid precursor protein	24494(Tax:10116)	351	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|processing processing|compound|END_ENTITY	Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid_precursor_protein processing in rat primary cortical neurons via up-regulation of the P2Y -LRB- 2 -RRB- receptor .
15126358	0	Interleukin-1beta	0,17	angiopoietin-1	28,42	Interleukin-1beta	angiopoietin-1	3553	284	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells .
15833737	0	Interleukin-1beta	0,17	beta2_adrenoreceptor	43,63	Interleukin-1beta	beta2 adrenoreceptor	3553	154	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Interleukin-1beta differentially regulates beta2_adrenoreceptor and prostaglandin_E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells .
9614202	0	Interleukin-1beta	0,17	bradykinin	26,36	Interleukin-1beta	bradykinin	3553	3827	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta induces bradykinin B2_receptor gene expression through a prostanoid cyclic_AMP-dependent pathway in human bronchial smooth muscle cells .
19233230	0	Interleukin-1beta	0,17	chemerin	46,54	Interleukin-1beta	chemerin	16176(Tax:10090)	71660(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro .
10976987	0	Interleukin-1beta	0,17	connexin_43	57,68	Interleukin-1beta	connexin 43	100008990(Tax:9986)	100008935(Tax:9986)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Interleukin-1beta increases the functional expression of connexin_43 in articular chondrocytes : evidence for a Ca2 + - dependent mechanism .
11686835	0	Interleukin-1beta	0,17	cyclo-oxygenase-2	26,43	Interleukin-1beta	cyclo-oxygenase-2	3553	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric_cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways .
10537081	0	Interleukin-1beta	0,17	cyclooxygenase-2	88,104	Interleukin-1beta	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|system system|amod|END_ENTITY	Interleukin-1beta induces substance P release from primary afferent neurons through the cyclooxygenase-2 system .
11032891	0	Interleukin-1beta	0,17	cyclooxygenase-2	26,42	Interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Interleukin-1beta induces cyclooxygenase-2 and prostaglandin_E -LRB- 2 -RRB- synthesis in human neuroblastoma cells : involvement of p38_mitogen-activated_protein_kinase and nuclear factor-kappaB .
12107235	0	Interleukin-1beta	0,17	cyclooxygenase-2	27,43	Interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	elevates|nsubj|START_ENTITY elevates|dobj|level level|amod|END_ENTITY	Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells : an effect mediated by extracellularly regulated kinases 1 and 2 .
12391274	0	Interleukin-1beta	0,17	cyclooxygenase-2	60,76	Interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells .
14670842	0	Interleukin-1beta	0,17	cyclooxygenase-2	208,224	Interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	attenuate|dep|START_ENTITY production|amod|attenuate smooth|nsubj|production smooth|advcl|prostacyclin prostacyclin|nmod|induction induction|amod|END_ENTITY	Interleukin-1beta , transforming_growth_factor-beta1 , and bradykinin attenuate cyclic_AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin_E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1 , 2 , and 4 .
19393083	0	Interleukin-1beta	0,17	cyclooxygenase-2	78,94	Interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|xcomp|induce induce|xcomp|END_ENTITY	Interleukin-1beta and fibroblast_growth_factor_receptor_1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis .
11250126	0	Interleukin-1beta	0,17	cyclooxygenase_2	26,42	Interleukin-1beta	cyclooxygenase 2	3553	5743	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta induced cyclooxygenase_2 expression and prostaglandin_E2 secretion by human neuroblastoma cells : implications for Alzheimer 's _ disease .
15039285	0	Interleukin-1beta	0,17	fibrinogen	45,55	Interleukin-1beta	fibrinogen	3553	2244	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form .
11726788	0	Interleukin-1beta	0,17	galectin-9	29,39	Interleukin-1beta	galectin-9	3553	3965	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta stimulates galectin-9 expression in human astrocytes .
9931117	0	Interleukin-1beta	0,17	inducible_nitric_oxide_synthase	32,63	Interleukin-1beta	inducible nitric oxide synthase	3553	4843	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Interleukin-1beta regulation of inducible_nitric_oxide_synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes .
11108281	0	Interleukin-1beta	0,17	insulin-like_growth_factor_binding_protein-1	44,88	Interleukin-1beta	insulin-like growth factor binding protein-1	101023446	101026642	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin-1beta induces the expression of insulin-like_growth_factor_binding_protein-1 during decidualization in the primate .
10467171	0	Interleukin-1beta	0,17	interleukin-6	26,39	Interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Interleukin-1beta induces interleukin-6 production through the production of prostaglandin_E -LRB- 2 -RRB- in human osteoblasts , MG-63 cells .
16202978	0	Interleukin-1beta	0,17	interleukin-6	26,39	Interleukin-1beta	interleukin-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	Interleukin-1beta targets interleukin-6 in progressing dextran sulfate_sodium-induced experimental colitis .
21398280	0	Interleukin-1beta	0,17	interleukin-6	65,78	Interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|pathway pathway|amod|END_ENTITY	Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway .
9927320	0	Interleukin-1beta	0,17	interleukin-6	63,76	Interleukin-1beta	interleukin-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|amod|END_ENTITY	Interleukin-1beta and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro : a potential role for lysophosphatidylcholine .
12089685	0	Interleukin-1beta	0,17	interleukin-8	29,42	Interleukin-1beta	interleukin-8	3553	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Interleukin-1beta stimulates interleukin-8 production and gene expression in synovial cells from human temporomandibular_joint .
11311405	0	Interleukin-1beta	0,17	lipocortin_1	44,56	Interleukin-1beta	lipocortin 1	24494(Tax:10116)	25380(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|mRNA mRNA|amod|END_ENTITY	Interleukin-1beta induces the expression of lipocortin_1 mRNA in cultured rat cortical astrocytes .
14746807	0	Interleukin-1beta	0,17	macrophage_inflammatory_protein-1beta	26,63	Interleukin-1beta	macrophage inflammatory protein-1beta	3553	6351	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta induces macrophage_inflammatory_protein-1beta expression in human hepatocytes .
15272234	0	Interleukin-1beta	0,17	matrix_metalloproteinase-2	29,55	Interleukin-1beta	matrix metalloproteinase-2	3553	4313	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta stimulates matrix_metalloproteinase-2 expression via a prostaglandin_E2-dependent mechanism in human chondrocytes .
16987994	0	Interleukin-1beta	0,17	matrix_metalloproteinase-2	55,81	Interleukin-1beta	matrix metalloproteinase-2	3553	4313	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Interleukin-1beta increases expression and activity of matrix_metalloproteinase-2 in cardiac microvascular endothelial cells : role of PKCalpha/beta1 and MAPKs .
19671357	0	Interleukin-1beta	1,18	matrix_metalloproteinase-2	31,57	Interleukin-1beta	matrix metalloproteinase-2	3553	4313	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	-LSB- Interleukin-1beta upregulates matrix_metalloproteinase-2 expression and activity in cardiac fibroblasts via nitric_oxide synthase pathway -RSB- .
11483667	0	Interleukin-1beta	0,17	neurofilament_light	45,64	Interleukin-1beta	neurofilament light	3553	4747	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin-1beta up-regulates expression of neurofilament_light in human neuronal cells .
11277982	0	Interleukin-1beta	0,17	neuropeptide_Y	40,54	Interleukin-1beta	neuropeptide Y	3553	4852	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin-1beta induces expression of neuropeptide_Y in primary astrocyte cultures in a cytokine-specific manner : induction in human but not rat astrocytes .
10623442	0	Interleukin-1beta	0,17	ornithine_decarboxylase	26,49	Interleukin-1beta	ornithine decarboxylase	24494(Tax:10116)	24609(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Interleukin-1beta induces ornithine_decarboxylase activity in insulin-producing cells .
12569180	0	Interleukin-1beta	0,17	oxytocinase	62,73	Interleukin-1beta	oxytocinase	3553	4012	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Interleukin-1beta stimulates placental_leucine_aminopeptidase / oxytocinase expression in BeWo choriocarcinoma cells .
10919268	0	Interleukin-1beta	0,17	phospholipase_D-1	28,45	Interleukin-1beta	phospholipase D-1	24494(Tax:10116)	25096(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interleukin-1beta regulates phospholipase_D-1 expression in rat pancreatic beta-cells .
12569180	0	Interleukin-1beta	0,17	placental_leucine_aminopeptidase	29,61	Interleukin-1beta	placental leucine aminopeptidase	3553	4012	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Interleukin-1beta stimulates placental_leucine_aminopeptidase / oxytocinase expression in BeWo choriocarcinoma cells .
17071533	0	Interleukin-1beta	0,17	vascular_endothelial_growth_factor	28,62	Interleukin-1beta	vascular endothelial growth factor	3553	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	Interleukin-1beta regulates vascular_endothelial_growth_factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts .
18309287	0	Interleukin-2	0,13	Akt	53,56	Interleukin-2	Akt	3558	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS .
8943845	0	Interleukin-2	0,13	BAG-1	33,38	Interleukin-2	BAG-1	3558	573	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- upregulates BAG-1 gene expression through serine-rich region within IL-2 receptor beta c chain .
20235165	0	Interleukin-2	0,13	BCL10	51,56	Interleukin-2	BCL10	3558	8915	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer_lymphoma cells .
10720515	0	Interleukin-2	0,13	CCR5	92,96	Interleukin-2	CCR5	3558	1234	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin-2 up-regulates expression of the human_immunodeficiency_virus fusion coreceptor CCR5 by CD4 + lymphocytes in vivo .
15217455	0	Interleukin-2	0,13	CD25	68,72	Interleukin-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	blocks|nsubj|START_ENTITY blocks|dobj|activity activity|acl|caused caused|nmod|depletion depletion|nmod|cells cells|nummod|END_ENTITY	Interleukin-2 blocks the antitumour activity caused by depletion of CD25 cells in a murine renal_adenocarcinoma model .
15307180	0	Interleukin-2	0,13	CD25	35,39	Interleukin-2	CD25	3558	3559	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|function function|compound|END_ENTITY	Interleukin-2 is essential for CD4 + CD25 + regulatory T cell function .
25485946	0	Interleukin-2	68,81	CD25	96,100	Interleukin-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	Reactivity|nmod|START_ENTITY +|dobj|Reactivity +|nmod|Expression Expression|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
10720515	0	Interleukin-2	0,13	CD4	100,103	Interleukin-2	CD4	3558	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|CCR5 CCR5|nmod|+ +|compound|END_ENTITY	Interleukin-2 up-regulates expression of the human_immunodeficiency_virus fusion coreceptor CCR5 by CD4 + lymphocytes in vivo .
12370501	0	Interleukin-2	0,13	CD4	26,29	Interleukin-2	CD4	3558	920	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|dobj|reconstitution reconstitution|compound|END_ENTITY	Interleukin-2 accelerates CD4 cell reconstitution in HIV-infected patients with severe immunosuppression despite highly active antiretroviral therapy : the ILSTIM study -- ANRS 082 .
15075538	0	Interleukin-2	0,13	CD4	60,63	Interleukin-2	CD4	3558	920	Gene	Gene	exerts|nsubj|START_ENTITY exerts|dobj|effect effect|nmod|dynamics dynamics|compound|END_ENTITY	Interleukin-2 immunotherapy exerts a differential effect on CD4 and CD8 T cell dynamics .
15307180	0	Interleukin-2	0,13	CD4	31,34	Interleukin-2	CD4	3558	920	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|function function|compound|END_ENTITY	Interleukin-2 is essential for CD4 + CD25 + regulatory T cell function .
17312008	0	Interleukin-2	0,13	CD4	23,26	Interleukin-2	CD4	3558	920	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|memory memory|compound|END_ENTITY	Interleukin-2 enhances CD4 + T cell memory by promoting the generation of IL-7R_alpha-expressing cells .
17671219	0	Interleukin-2	0,13	CD4	40,43	Interleukin-2	CD4	3558	920	Gene	Gene	administration|amod|START_ENTITY alters|nsubj|administration alters|dobj|pool pool|compound|END_ENTITY	Interleukin-2 administration alters the CD4 + FOXP3 + T-cell pool and tumor trafficking in patients with ovarian_carcinoma .
18702891	0	Interleukin-2	0,13	CD4	90,93	Interleukin-2	CD4	3558	920	Gene	Gene	treatment|amod|START_ENTITY treatment|nmod|child child|nmod|T_lymphocytopenia T_lymphocytopenia|compound|END_ENTITY	Interleukin-2 treatment for persistent cryptococcal_meningitis in a child with idiopathic CD4 -LRB- + -RRB- T_lymphocytopenia .
24416451	0	Interleukin-2	91,104	CD4	42,45	Interleukin-2	CD4	3558	920	Gene	Gene	conditions|compound|START_ENTITY priming|nmod|conditions survival|acl|priming survival|compound|END_ENTITY	Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions .
25119341	0	Interleukin-2	70,83	CD4	122,125	Interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY activation|nmod|cells independent|nsubj|activation independent|nmod|help help|compound|END_ENTITY	Bystander activation and anti-tumor effects of CD8 + T cells following Interleukin-2 based immunotherapy is independent of CD4 + T cell help .
25485946	0	Interleukin-2	68,81	CD4	30,33	Interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	Reactivity|nmod|START_ENTITY +|dobj|Reactivity +|nsubj|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
7868930	0	Interleukin-2	98,111	CD4	1,4	Interleukin-2	CD4	3558	920	Gene	Gene	IL-2|appos|START_ENTITY treated|nmod|IL-2 patients|acl|treated induce|nmod|patients induce|nsubj|TIL TIL|compound|END_ENTITY	-LSB- CD4 TIL -LRB- Tumor_Infiltrating_Lymphocytes -RRB- induce complete response in patients treated with IL-2 -LRB- Interleukin-2 -RRB- .
7909457	0	Interleukin-2	0,13	CD4	71,74	Interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Interleukin-2 inhibits graft-versus-host_disease-promoting activity of CD4 + cells while preserving CD4 - and CD8-mediated graft-versus-leukemia effects .
7909457	0	Interleukin-2	0,13	CD4	99,102	Interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preserving preserving|dobj|effects effects|amod|END_ENTITY	Interleukin-2 inhibits graft-versus-host_disease-promoting activity of CD4 + cells while preserving CD4 - and CD8-mediated graft-versus-leukemia effects .
15577620	0	Interleukin-2	0,13	CD8	31,34	Interleukin-2	CD8	3558	925	Gene	Gene	therapy|amod|START_ENTITY restores|nsubj|therapy restores|dobj|responses responses|nummod|END_ENTITY	Interleukin-2 therapy restores CD8 cell non-cytotoxic anti-HIV responses in primary_infection subjects receiving HAART .
19296053	0	Interleukin-2	0,13	CD8	17,20	Interleukin-2	CD8	3558	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Interleukin-2 in CD8 + T cells correlates with Banff score during organ rejection in liver transplant recipients .
21621553	0	Interleukin-2	0,13	CD8	40,43	Interleukin-2	CD8	3558	925	Gene	Gene	rescues|nsubj|START_ENTITY rescues|dobj|cells cells|compound|END_ENTITY	Interleukin-2 rescues helpless effector CD8 + T cells by diminishing the susceptibility to TRAIL mediated death .
17671219	0	Interleukin-2	0,13	FOXP3	44,49	Interleukin-2	FOXP3	3558	50943	Gene	Gene	administration|amod|START_ENTITY alters|nsubj|administration alters|dobj|pool pool|compound|END_ENTITY	Interleukin-2 administration alters the CD4 + FOXP3 + T-cell pool and tumor trafficking in patients with ovarian_carcinoma .
16805135	0	Interleukin-2	0,13	IL-2	15,19	Interleukin-2	IL-2	3558	3558	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- expression in livers of patients with chronic hepatitis_C_virus _ -LRB- HCV -RRB- infection .
2788510	0	Interleukin-2	0,13	LAK	31,34	Interleukin-2	LAK	3558	80216	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Interleukin-2 with and without LAK cells in metastatic renal_cell_carcinoma : the Lyon first-year experience in 20 patients .
9129156	0	Interleukin-2	0,13	SHP-2	50,55	Interleukin-2	SHP-2	3558	5781	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2_receptor beta chain .
11435608	0	Interleukin-2	0,13	STAT5	102,107	Interleukin-2	STAT5	3558	6776	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|mechanism mechanism|nmod|END_ENTITY	Interleukin-2 inhibits glucocorticoid_receptor transcriptional activity through a mechanism involving STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- but not AP-1 .
17363300	0	Interleukin-2	0,13	STAT5	28,33	Interleukin-2	STAT5	3558	6776	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|T T|compound|END_ENTITY	Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation .
23167249	0	Interleukin-2	0,13	STAT5	142,147	Interleukin-2	STAT5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|suppresses suppresses|nmod|pathways pathways|compound|END_ENTITY	Interleukin-2 / anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced_arthritis in mice by fortifying interleukin-2 / STAT5 signalling pathways .
8617237	0	Interleukin-2	0,13	STAT5	28,33	Interleukin-2	STAT5	3558	6776	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway .
12377952	0	Interleukin-2	0,13	Stat5	85,90	Interleukin-2	Stat5	3558	6776	Gene	Gene	cytokines|amod|START_ENTITY stimulate|nsubj|cytokines stimulate|dobj|phosphorylation phosphorylation|nmod|motif motif|nmod|factors factors|amod|END_ENTITY	Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells : resistance to suppression of multiple serine kinase pathways .
2993359	0	Interleukin-2	0,13	Tac_antigen	24,35	Interleukin-2	Tac antigen	3558	3559	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Interleukin-2 receptor -LRB- Tac_antigen -RRB- expressed on adult_T_cell_leukemia cells .
9258403	0	Interleukin-2	0,13	angiotensin_II	46,60	Interleukin-2	angiotensin II	3558	183	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Interleukin-2 modulates the responsiveness to angiotensin_II in cultured vascular smooth muscle cells .
9027322	0	Interleukin-2	0,13	c-fos	39,44	Interleukin-2	c-fos	3558	2353	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- and IL-6 regulate c-fos protooncogene expression in human pituitary_adenoma explants .
7853199	0	Interleukin-2	0,13	corticotropin-releasing_factor	29,59	Interleukin-2	corticotropin-releasing factor	3558	1392	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- induces corticotropin-releasing_factor -LRB- CRF -RRB- release from the amygdala and involves a nitric_oxide-mediated signaling ; comparison with the hypothalamic response .
21262836	0	Interleukin-2	0,13	flt3L	67,72	Interleukin-2	flt3L	16183(Tax:10090)	14256(Tax:10090)	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	Interleukin-2 inhibits FMS-like_tyrosine_kinase_3_receptor ligand -LRB- flt3L -RRB- - dependent development and function of conventional and plasmacytoid dendritic cells .
11435608	0	Interleukin-2	0,13	glucocorticoid_receptor	23,46	Interleukin-2	glucocorticoid receptor	3558	2908	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Interleukin-2 inhibits glucocorticoid_receptor transcriptional activity through a mechanism involving STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- but not AP-1 .
7797254	0	Interleukin-2	0,13	interferon-gamma	57,73	Interleukin-2	interferon-gamma	3558	3458	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|step step|nmod|activation activation|nmod|expression expression|amod|END_ENTITY	Interleukin-2 induces an early step in the activation of interferon-gamma gene expression .
8382095	0	Interleukin-2	0,13	interferon-gamma	15,31	Interleukin-2	interferon-gamma	3558	3458	Gene	Gene	lavage|advmod|START_ENTITY lavage|nsubj|END_ENTITY	Interleukin-2 , interferon-gamma and natural killer cell activity in bronchoalveolar lavage fluid from marrow transplant recipients with cytomegalovirus_pneumonia .
23167249	0	Interleukin-2	0,13	interleukin-2	128,141	Interleukin-2	interleukin-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|suppresses suppresses|nmod|pathways pathways|compound|END_ENTITY	Interleukin-2 / anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced_arthritis in mice by fortifying interleukin-2 / STAT5 signalling pathways .
3311208	0	Interleukin-2	0,13	interleukin-2	41,54	Interleukin-2	interleukin-2	3558	3558	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Interleukin-2 production and response to interleukin-2 by peripheral blood mononuclear cells from patients after bone marrow transplantation : II .
7774310	0	Interleukin-2	0,13	interleukin-2	26,39	Interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Interleukin-2 and soluble interleukin-2 receptor in bronchoalveolar lavage fluid from patients with bronchial_asthma .
8490104	0	Interleukin-2	0,13	interleukin-2	26,39	Interleukin-2	interleukin-2	3558	3558	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Interleukin-2 and soluble interleukin-2 receptor levels in children with active pulmonary_tuberculosis and atypical mycobacterial adenitis .
2075380	0	Interleukin-2	0,13	interleukin-2_receptor	23,45	Interleukin-2	interleukin-2 receptor	3558	3559	Gene	Gene	factor|advmod|START_ENTITY factor|nsubj|END_ENTITY	Interleukin-2 , soluble interleukin-2_receptor and tumor necrosis factor in sera from patients with rheumatoid_arthritis .
9166099	0	Interleukin-2	0,13	interleukin-2_receptor	61,83	Interleukin-2	interleukin-2 receptor	3558	3559	Gene	Gene	protein|amod|START_ENTITY protein|dep|therapy therapy|nmod|malignancies malignancies|amod|END_ENTITY	Interleukin-2 fusion protein : an investigational therapy for interleukin-2_receptor expressing malignancies .
15493273	0	Interleukin-2	0,13	lymphocyte_function-associated_antigen-one	42,84	Interleukin-2	lymphocyte function-associated antigen-one	3558	3683	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-2 modulates the expression of lymphocyte_function-associated_antigen-one -LRB- LFA-1 -RRB- and p150 ,95 during the generation of lymphokine-activated killer -LRB- LAK -RRB- cells .
2783911	0	Interleukin-2	0,13	ornithine_decarboxylase	40,63	Interleukin-2	ornithine decarboxylase	16183(Tax:10090)	18263(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Interleukin-2 regulates the activity of ornithine_decarboxylase in a cloned murine T lymphocytic cell line : evidence for a protein_kinase_C-dependent pathway .
10022437	0	Interleukin-2	0,13	prolactin	52,61	Interleukin-2	prolactin	3558	5617	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|END_ENTITY	Interleukin-2 inhibits the synthesis and release of prolactin from human decidual cells .
1639773	0	Interleukin-2	0,13	raf-1	79,84	Interleukin-2	raf-1	3558	5894	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2_receptor into the cytosol .
7528668	0	Interleukin-2	0,13	stat3	76,81	Interleukin-2	stat3	3558	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes .
23271730	0	Interleukin-20	0,14	extracellular_signal-regulated_kinase	66,103	Interleukin-20	extracellular signal-regulated kinase	50604	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Interleukin-20 promotes migration of bladder_cancer cells through extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated MMP-9 protein expression leading to nuclear factor -LRB- NF-kB -RRB- activation by inducing the up-regulation of p21 -LRB- WAF1 -RRB- protein expression .
18190607	0	Interleukin-21	0,14	CD4	87,90	Interleukin-21	CD4	60505(Tax:10090)	12504(Tax:10090)	Gene	Gene	antigen|amod|START_ENTITY uptake|nsubj|antigen uptake|dobj|activity activity|nmod|proliferation proliferation|compound|END_ENTITY	Interleukin-21 stimulates antigen uptake , protease activity , survival and induction of CD4 + T cell proliferation by murine macrophages .
21227406	0	Interleukin-21	0,14	CD4	105,108	Interleukin-21	CD4	59067	920	Gene	Gene	maintains|nsubj|START_ENTITY maintains|nmod|monocytes monocytes|nmod|production production|nmod|cells cells|amod|IL-10 IL-10|nmod|T T|compound|END_ENTITY	Interleukin-21 maintains the expression of CD16 on monocytes via the production of IL-10 by human na ve CD4 + T cells .
24416451	0	Interleukin-21	0,14	CD4	42,45	Interleukin-21	CD4	59067	920	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|survival survival|compound|END_ENTITY	Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions .
26744522	0	Interleukin-21	68,82	CD8	96,99	Interleukin-21	CD8	59067	925	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Cells Cells|compound|END_ENTITY	Improved Treatment of Breast_Cancer with Anti-HER2 Therapy Requires Interleukin-21 Signaling in CD8 + T Cells .
25939532	0	Interleukin-22	0,14	HB-EGF	27,33	Interleukin-22	HB-EGF	50616	1839	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Interleukin-22 upregulates HB-EGF expression in HaCaT cells via JAK2/STAT3 and ERK1/2 signalling .
15120652	0	Interleukin-22	0,14	STAT3	25,30	Interleukin-22	STAT3	50616	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells .
21674558	0	Interleukin-22	0,14	STAT3	72,77	Interleukin-22	STAT3	50616	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Interleukin-22 promotes human hepatocellular_carcinoma by activation of STAT3 .
21564072	0	Interleukin-22	0,14	filaggrin	29,38	Interleukin-22	filaggrin	50616	2312	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes .
20131264	0	Interleukin-23	0,14	T-bet	59,64	Interleukin-23	T-bet	83430(Tax:10090)	57765(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22 , but not interleukin-21 , in autoimmune experimental arthritis .
20404153	0	Interleukin-23	0,14	phosphatase_2A	80,94	Interleukin-23	phosphatase 2A	27178	5524	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase_2A .
26222305	0	Interleukin-23_Receptor	0,23	IL-23_Receptor	72,86	Interleukin-23 Receptor	IL-23 Receptor	149233	149233	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Interleukin-23_Receptor Gene Polymorphism May Enhance Expression of the IL-23_Receptor , IL-17 , TNF-a and IL-6 in Behcet 's _ Disease .
26222305	0	Interleukin-23_Receptor	0,23	IL-23_Receptor	72,86	Interleukin-23 Receptor	IL-23 Receptor	149233	149233	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Interleukin-23_Receptor Gene Polymorphism May Enhance Expression of the IL-23_Receptor , IL-17 , TNF-a and IL-6 in Behcet 's _ Disease .
26417027	0	Interleukin-24	0,14	IL-24	16,21	Interleukin-24	IL-24	11009	11009	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Interleukin-24 -LRB- IL-24 -RRB- Expression and Biological Impact on HECV Endothelial Cells .
23106660	0	Interleukin-25	0,14	IL-17RB	118,125	Interleukin-25	IL-17RB	64806	55540	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|interaction interaction|nmod|END_ENTITY	Interleukin-25 promotes basic_fibroblast_growth_factor expression by human endothelial cells through interaction with IL-17RB , but not IL-17RA .
20944558	0	Interleukin-25	0,14	TNF-a	54,59	Interleukin-25	TNF-a	64806	7124	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Interleukin-25 production is differently regulated by TNF-a and TGF-b1 in the human gut .
23106660	0	Interleukin-25	0,14	basic_fibroblast_growth_factor	24,54	Interleukin-25	basic fibroblast growth factor	64806	2247	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Interleukin-25 promotes basic_fibroblast_growth_factor expression by human endothelial cells through interaction with IL-17RB , but not IL-17RA .
21506940	0	Interleukin-27	0,14	tumour_necrosis_factor-a	42,66	Interleukin-27	tumour necrosis factor-a	246778	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Interleukin-27 enhances the production of tumour_necrosis_factor-a and interferon-y by bone marrow T lymphocytes in aplastic_anaemia .
24973639	0	Interleukin-28A	0,15	IFN-y	25,30	Interleukin-28A	IFN-y	282616	3458	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|amod|END_ENTITY	Interleukin-28A promotes IFN-y production by peripheral blood mononuclear cells from patients with Beh __ et 's _ disease .
26950250	0	Interleukin-2_Inducible_T-Cell_Kinase	72,109	ITK	111,114	Interleukin-2 Inducible T-Cell Kinase	ITK	3702	3702	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2_Inducible_T-Cell_Kinase -LRB- ITK -RRB- Inhibitors .
11726317	0	Interleukin-3	0,13	CD123	36,41	Interleukin-3	CD123	3562	3563	Gene	Gene	chain|compound|START_ENTITY chain|appos|END_ENTITY	Interleukin-3 receptor alpha chain -LRB- CD123 -RRB- is widely expressed in hematologic_malignancies .
26474588	0	Interleukin-3	0,13	CD123	32,37	Interleukin-3	CD123	3562	3563	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Interleukin-3 receptor a chain -LRB- CD123 -RRB- is preferentially expressed in immature T-ALL and may not associate with outcomes of chemotherapy .
17624239	0	Interleukin-3	0,13	CD203C	48,54	Interleukin-3	CD203C	3562	5169	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Interleukin-3 promotes the expression of E-NPP3 / CD203C on human blood basophils in healthy subjects and in patients with birch pollen allergy .
9110989	0	Interleukin-3	0,13	SHIP	68,72	Interleukin-3	SHIP	3562	3635	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2 .
9361008	0	Interleukin-3	0,13	SHP2	70,74	Interleukin-3	SHP2	16187(Tax:10090)	19247(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells .
9395328	0	Interleukin-3	0,13	Syk	24,27	Interleukin-3	Syk	3562	6850	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Interleukin-3 activates Syk in a human myeloblastic_leukemia cell line , AML193 .
15060062	0	Interleukin-3	0,13	betaIL-3	36,44	Interleukin-3	betaIL-3	16187(Tax:10090)	12984(Tax:10090)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains .
8280711	0	Interleukin-3	0,13	interleukin-2	64,77	Interleukin-3	interleukin-2	3562	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Interleukin-3 inhibits the generation of nonspecific killers by interleukin-2 .
9242874	0	Interleukin-3	0,13	interleukin-5	14,27	Interleukin-3	interleukin-5	3562	3567	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Interleukin-3 interleukin-5 , and granulocyte-macrophage_colony-stimulating_factor expression in nasal_polyps .
8630401	0	Interleukin-3	0,13	tumor_necrosis_factor_alpha	30,57	Interleukin-3	tumor necrosis factor alpha	3562	7124	Gene	Gene	cooperates|compound|START_ENTITY cooperates|nmod|END_ENTITY	Interleukin-3 cooperates with tumor_necrosis_factor_alpha for the development of human dendritic/Langerhans cells from cord blood CD34 + hematopoietic_progenitor_cells .
24396867	0	Interleukin-32	0,14	IL-32b	32,38	Interleukin-32	IL-32b	9235	9235	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Interleukin-32 interacts with IL-32b and inhibits IL-32b-mediated IL-10 production .
24512848	0	Interleukin-32	0,14	IL-32b	32,38	Interleukin-32	IL-32b	9235	9235	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Interleukin-32 interacts with IL-32b and inhibits IL-32b-mediated IL-10 production .
21113894	0	Interleukin-33	0,14	IL-18	43,48	Interleukin-33	IL-18	90865	3606	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Interleukin-33 , a novel member of the IL-1 / IL-18 cytokine family , in cardiology and cardiac surgery .
24105680	0	Interleukin-33	0,14	ST2	15,18	Interleukin-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|axis axis|compound|END_ENTITY	Interleukin-33 / ST2 axis promotes breast_cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells .
24866242	0	Interleukin-33	0,14	ST2	15,18	Interleukin-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|signaling signaling|compound|END_ENTITY	Interleukin-33 / ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic_obstructive_pulmonary_disease mice .
25712928	0	Interleukin-33	32,46	ST2	47,50	Interleukin-33	ST2	90865	6761	Gene	Gene	Role|nmod|START_ENTITY Role|dep|Axis Axis|compound|END_ENTITY	Crucial and Diverse Role of the Interleukin-33 / ST2 Axis in Infectious_Diseases .
25896545	0	Interleukin-33	0,14	ST2	15,18	Interleukin-33	ST2	90865	6761	Gene	Gene	START_ENTITY|parataxis|attenuates attenuates|nsubj|system system|compound|END_ENTITY	Interleukin-33 / ST2 system attenuates aldosterone-induced adipogenesis and inflammation .
22540331	0	Interleukin-33	0,14	interleukin-17F	23,38	Interleukin-33	interleukin-17F	90865	112744	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Interleukin-33 induces interleukin-17F in bronchial epithelial cells .
23711851	0	Interleukin-33	0,14	tumor_necrosis_factor_alpha	63,90	Interleukin-33	tumor necrosis factor alpha	90865	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Interleukin-33 synergistically enhances immune complex-induced tumor_necrosis_factor_alpha and interleukin-8 production in cultured human synovium-derived mast cells .
9870918	0	Interleukin-4	0,13	15-lipoxygenase	23,38	Interleukin-4	15-lipoxygenase	3565	246	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Interleukin-4 enhances 15-lipoxygenase activity and incorporation of 15 -LRB- S -RRB- - HETE into cellular phospholipids in cultured pulmonary epithelial cells .
16675443	0	Interleukin-4	0,13	15-lipoxygenase-1	22,39	Interleukin-4	15-lipoxygenase-1	3565	246	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves_disease .
18819102	0	Interleukin-4	0,13	CBP/p300	50,58	Interleukin-4	CBP/p300	3565	1387;2033	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Interleukin-4 activates androgen_receptor through CBP/p300 .
17073944	0	Interleukin-4	0,13	CCR7	54,58	Interleukin-4	CCR7	3565	1236	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Interleukin-4 promotes human CD8 T cell expression of CCR7 .
20201040	0	Interleukin-4	0,13	CD127	28,33	Interleukin-4	CD127	3565	3575	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8 + T cells .
20713631	0	Interleukin-4	0,13	CD209	42,47	Interleukin-4	CD209	3565	30835	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-4 regulates the expression of CD209 and subsequent uptake of Mycobacterium_leprae by Schwann cells in human leprosy .
19191911	0	Interleukin-4	0,13	CD4	92,95	Interleukin-4	CD4	3565	920	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dep|adaptive adaptive|dobj|cells cells|compound|END_ENTITY	Interleukin-4 suppresses the cytotoxic potential of in vitro generated , adaptive regulatory CD4 T cells by down-regulation of granzyme_B .
24139939	1	Interleukin-4	71,84	CD4	124,127	Interleukin-4	CD4	287287(Tax:10116)	24932(Tax:10116)	Gene	Gene	maintain|nsubj|START_ENTITY maintain|dobj|CD25 CD25|compound|END_ENTITY	Interleukin-4 does not maintain alloantigen specific CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Treg .
3262830	0	Interleukin-4	0,13	CD4	46,49	Interleukin-4	CD4	3565	920	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|clones clones|compound|END_ENTITY	Interleukin-4 mediates CD8 induction on human CD4 + T-cell clones .
11175852	0	Interleukin-4	0,13	CD8	103,106	Interleukin-4	CD8	3565	925	Gene	Gene	acts|nsubj|START_ENTITY acts|xcomp|counter-regulate counter-regulate|dobj|responses responses|compound|END_ENTITY	Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8 + T-cell responses .
15958076	0	Interleukin-4	0,13	CD8	97,100	Interleukin-4	CD8	3565	925	Gene	Gene	down-regulation|amod|START_ENTITY down-regulation|nmod|skin skin|acl|homing homing|nmod|cells cells|compound|END_ENTITY	Interleukin-4 induced down-regulation of skin homing receptor expression by human viral-specific CD8 T cells may contribute to atopic risk of cutaneous_infection .
17073944	0	Interleukin-4	0,13	CD8	29,32	Interleukin-4	CD8	3565	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Interleukin-4 promotes human CD8 T cell expression of CCR7 .
3262830	0	Interleukin-4	0,13	CD8	23,26	Interleukin-4	CD8	3565	925	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nummod|END_ENTITY	Interleukin-4 mediates CD8 induction on human CD4 + T-cell clones .
8641459	0	Interleukin-4	0,13	Hsp90alpha	49,59	Interleukin-4	Hsp90alpha	3565	3320	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Interleukin-4 upregulates the heat_shock protein Hsp90alpha and enhances transcription of a reporter gene coupled to a single heat_shock element .
24518693	0	Interleukin-4	27,40	IL-4	42,46	Interleukin-4	IL-4	3565	3565	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	rs2243268 and rs2243274 of Interleukin-4 -LRB- IL-4 -RRB- gene are associated with reduced risk for extrapulmonary and severe tuberculosis in Chinese Han children .
7939136	0	Interleukin-4	0,13	IL-4	15,19	Interleukin-4	IL-4	3565	3565	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces down-modulation and shedding of the p55 tumour_necrosis_factor_receptor and inhibits TNF_alpha 's effect on rheumatoid synovial fibroblasts .
8390454	0	Interleukin-4	0,13	IL-4_receptor	139,152	Interleukin-4	IL-4 receptor	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|IL-4_receptor IL-4_receptor|nmod|line line|amod|3-kinase 3-kinase|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
8390454	0	Interleukin-4	0,13	IL-4_receptor	69,82	Interleukin-4	IL-4 receptor	16189(Tax:10090)	16190(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- induces protein tyrosine phosphorylation of the IL-4_receptor and association of phosphatidylinositol 3-kinase to the IL-4_receptor in a mouse T cell line , HT2 .
7520776	0	Interleukin-4	0,13	Kit_and_tryptase	41,57	Interleukin-4	Kit and tryptase	3565	3815	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Interleukin-4 inhibits the expression of Kit_and_tryptase during stem_cell_factor-dependent development of human mast cells from fetal liver cells .
15752732	0	Interleukin-4	0,13	NFATc1	51,57	Interleukin-4	NFATc1	16189(Tax:10090)	18018(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos : a possible mechanism for downregulation of osteoclastogenesis .
21751242	0	Interleukin-4	0,13	NFATc1	37,43	Interleukin-4	NFATc1	3565	4772	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6 : a novel mechanism mediating its blockade of osteoclastogenesis .
10339476	0	Interleukin-4	0,13	Raf-1	30,35	Interleukin-4	Raf-1	16189(Tax:10090)	110157(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase .
10631093	0	Interleukin-4	0,13	STAT6	23,28	Interleukin-4	STAT6	3565	6778	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nummod|END_ENTITY	Interleukin-4 mediates STAT6 activation in 3T3-L1 preadipocytes but not adipocytes .
10982806	0	Interleukin-4	0,13	STAT6	14,19	Interleukin-4	STAT6	3565	6778	Gene	Gene	START_ENTITY|parataxis|represses represses|nsubj|END_ENTITY	Interleukin-4 / STAT6 represses STAT1 and NF-kappa_B-dependent transcription through distinct mechanisms .
11266117	0	Interleukin-4	0,13	STAT6	103,108	Interleukin-4	STAT6	3565	6778	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|complexes complexes|acl|containing containing|dobj|STAT6 STAT6|dep|evidence evidence|nmod|binding binding|nmod|monomer monomer|compound|END_ENTITY	Interleukin-4 induces two distinct GAS-binding complexes containing STAT6 : evidence for DNA binding of STAT6 monomer .
11266117	0	Interleukin-4	0,13	STAT6	68,73	Interleukin-4	STAT6	3565	6778	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|complexes complexes|acl|containing containing|dobj|END_ENTITY	Interleukin-4 induces two distinct GAS-binding complexes containing STAT6 : evidence for DNA binding of STAT6 monomer .
17134490	0	Interleukin-4	0,13	STAT6	103,108	Interleukin-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY mediated|nsubjpass|induction mediated|nmod|sites sites|compound|END_ENTITY	Interleukin-4 induction of the CC chemokine TARC -LRB- CCL17 -RRB- in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter .
18251702	0	Interleukin-4	0,13	STAT6	123,128	Interleukin-4	STAT6	3565	6778	Gene	Gene	START_ENTITY|dep|stimulate stimulate|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway .
19857574	0	Interleukin-4	0,13	STAT6	60,65	Interleukin-4	STAT6	3565	6778	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|protein protein|nmod|activation activation|nmod|END_ENTITY	Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells .
21751242	0	Interleukin-4	0,13	STAT6	59,64	Interleukin-4	STAT6	3565	6778	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6 : a novel mechanism mediating its blockade of osteoclastogenesis .
23935100	0	Interleukin-4	0,13	STAT6	77,82	Interleukin-4	STAT6	3565	6778	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin-4 induces senescence in human renal_carcinoma cell lines through STAT6 and p38 MAPK .
9092569	0	Interleukin-4	0,13	STAT6	113,118	Interleukin-4	STAT6	3565	6778	Gene	Gene	suppression|amod|START_ENTITY mediated|nsubjpass|suppression mediated|nmod|antagonism antagonism|compound|END_ENTITY	Interleukin-4 suppression of tumor_necrosis_factor_alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB .
24943510	0	Interleukin-4	0,13	Stat6	160,165	Interleukin-4	Stat6	3565	6778	Gene	Gene	up-regulation|amod|START_ENTITY involves|nsubj|up-regulation involves|dobj|the the|nmod|END_ENTITY	Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal_transducer_and_activator_of_transcription_6 -LRB- Stat6 -RRB- to the imperfect Stat6 sites .
24943510	0	Interleukin-4	0,13	Stat6	184,189	Interleukin-4	Stat6	3565	6778	Gene	Gene	up-regulation|amod|START_ENTITY involves|nsubj|up-regulation involves|dobj|the the|nmod|Stat6 Stat6|nmod|sites sites|amod|END_ENTITY	Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal_transducer_and_activator_of_transcription_6 -LRB- Stat6 -RRB- to the imperfect Stat6 sites .
26918372	0	Interleukin-4	0,13	Stat6	96,101	Interleukin-4	Stat6	3565	6778	Gene	Gene	Downregulation|compound|START_ENTITY Downregulation|nmod|Sequestration Sequestration|compound|END_ENTITY	Interleukin-4 Downregulation of Involucrin Expression in Human Epidermal Keratinocytes Involves Stat6 Sequestration of the Coactivator CREB-Binding_Protein .
17134490	0	Interleukin-4	0,13	TARC	122,126	Interleukin-4	TARC	16189(Tax:10090)	20295(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY mediated|nsubjpass|induction mediated|nmod|sites sites|nmod|promoter promoter|compound|END_ENTITY	Interleukin-4 induction of the CC chemokine TARC -LRB- CCL17 -RRB- in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter .
17134490	0	Interleukin-4	0,13	TARC	44,48	Interleukin-4	TARC	16189(Tax:10090)	20295(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Interleukin-4 induction of the CC chemokine TARC -LRB- CCL17 -RRB- in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter .
7556668	0	Interleukin-4	0,13	VCAM-1	69,75	Interleukin-4	VCAM-1	3565	7412	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Interleukin-4 induces endothelial vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by an NF-kappa_b-independent mechanism .
12970746	0	Interleukin-4	0,13	androgen_receptor	81,98	Interleukin-4	androgen receptor	3565	367	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Interleukin-4 enhances prostate-specific_antigen expression by activation of the androgen_receptor and Akt pathway .
18819102	0	Interleukin-4	0,13	androgen_receptor	24,41	Interleukin-4	androgen receptor	3565	367	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Interleukin-4 activates androgen_receptor through CBP/p300 .
17114647	0	Interleukin-4	0,13	caspase-3	23,32	Interleukin-4	caspase-3	3565	836	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Interleukin-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human T helper 2 cell differentiation .
11967989	0	Interleukin-4	0,13	connective_tissue_growth_factor	24,55	Interleukin-4	connective tissue growth factor	3565	1490	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Interleukin-4 regulates connective_tissue_growth_factor expression in human lung fibroblasts .
25207963	0	Interleukin-4	0,13	eomesodermin	24,36	Interleukin-4	eomesodermin	16189(Tax:10090)	13813(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Interleukin-4 regulates eomesodermin in CD8 + T cell development and differentiation .
3061382	0	Interleukin-4	0,13	interleukin-1	23,36	Interleukin-4	interleukin-1	3565	3552	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Interleukin-4 inhibits interleukin-1 synthesis by a posttranscriptional mechanism .
7628587	0	Interleukin-4	0,13	interleukin-1	41,54	Interleukin-4	interleukin-1	3565	3552	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Interleukin-4 inhibits the production of interleukin-1 by adult_T-cell_leukemia cells .
10085445	0	Interleukin-4	0,13	interleukin-10	30,44	Interleukin-4	interleukin-10	3565	3586	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|END_ENTITY	Interleukin-4 cooperates with interleukin-10 to inhibit vascular_permeability_factor release by peripheral blood mononuclear cells from patients with minimal-change nephrotic_syndrome .
12111847	0	Interleukin-4	0,13	interleukin-10	15,29	Interleukin-4	interleukin-10	287287(Tax:10116)	25325(Tax:10116)	Gene	Gene	induce|advmod|START_ENTITY induce|nsubj|END_ENTITY	Interleukin-4 , interleukin-10 , and interleukin-1-receptor antagonist but not transforming_growth_factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells .
10908690	0	Interleukin-4	0,13	interleukin-11	23,37	Interleukin-4	interleukin-11	3565	3589	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin-4 inhibits interleukin-11 production by rheumatoid synovial cells .
14871295	0	Interleukin-4	0,13	interleukin-2	35,48	Interleukin-4	interleukin-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Interleukin-4 selectively inhibits interleukin-2 secretion by lipopolysaccharide-activated dendritic cells .
10632444	0	Interleukin-4	0,13	interleukin-6	73,86	Interleukin-4	interleukin-6	3565	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interleukin-4 inhibits granulocyte-macrophage_colony-stimulating_factor , interleukin-6 , and tumor_necrosis_factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro .
15304279	0	Interleukin-4	0,13	interleukin-6	79,92	Interleukin-4	interleukin-6	3565	3569	Gene	Gene	interleukin-1|amod|START_ENTITY induced|nsubj|interleukin-1 induced|dobj|secretion secretion|nmod|END_ENTITY	Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells .
1779891	0	Interleukin-4	0,13	interleukin-6	28,41	Interleukin-4	interleukin-6	3565	3569	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|production production|amod|END_ENTITY	Interleukin-4 downregulates interleukin-6 production by human alveolar macrophages at protein and mRNA levels .
1912585	0	Interleukin-4	0,13	interleukin-6	66,79	Interleukin-4	interleukin-6	3565	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	Interleukin-4 inhibits growth of multiple_myelomas by suppressing interleukin-6 expression .
2335755	0	Interleukin-4	0,13	interleukin-6	28,41	Interleukin-4	interleukin-6	3565	3569	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|production production|amod|END_ENTITY	Interleukin-4 downregulates interleukin-6 production in human peripheral blood mononuclear cells .
21552940	0	Interleukin-4	0,13	lak	23,26	Interleukin-4	lak	3565	80216	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interleukin-4 inhibits lak and initial phase til activity via interleukin-2 receptor .
7805751	0	Interleukin-4	0,13	leukemia_inhibitory_factor	64,90	Interleukin-4	leukemia inhibitory factor	3565	3976	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Interleukin-4 but not interleukin-10 inhibits the production of leukemia_inhibitory_factor by rheumatoid synovium and synoviocytes .
11463954	0	Interleukin-4	0,13	nuclear_factor-erythroid_2	28,54	Interleukin-4	nuclear factor-erythroid 2	3565	4778	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Interleukin-4 downregulates nuclear_factor-erythroid_2 -LRB- NF-E2 -RRB- expression in primary megakaryocytes and in megakaryoblastic cell lines .
16601843	0	Interleukin-4	0,13	osteoprotegerin	39,54	Interleukin-4	osteoprotegerin	3565	4982	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Interleukin-4 differentially regulates osteoprotegerin expression and induces calcification in vascular smooth muscle cells .
18251702	0	Interleukin-4	0,13	osteoprotegerin	68,83	Interleukin-4	osteoprotegerin	3565	4982	Gene	Gene	START_ENTITY|dep|stimulate stimulate|dobj|END_ENTITY	Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway .
12970746	0	Interleukin-4	0,13	prostate-specific_antigen	23,48	Interleukin-4	prostate-specific antigen	3565	354	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Interleukin-4 enhances prostate-specific_antigen expression by activation of the androgen_receptor and Akt pathway .
1571090	0	Interleukin-4	0,13	tumor_necrosis_factor-alpha	39,66	Interleukin-4	tumor necrosis factor-alpha	3565	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interleukin-4 differentially regulates tumor_necrosis_factor-alpha gene expression by human T lymphocytes and monocytes .
15816837	0	Interleukin-4	0,13	tumor_necrosis_factor-alpha	119,146	Interleukin-4	tumor necrosis factor-alpha	3565	7124	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|enhancement enhancement|nmod|synthesis synthesis|acl|induced induced|nmod|END_ENTITY	Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor_necrosis_factor-alpha and interferon-gamma in human epidermis .
7556668	0	Interleukin-4	0,13	vascular_cell_adhesion_molecule-1	34,67	Interleukin-4	vascular cell adhesion molecule-1	3565	7412	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin-4 induces endothelial vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by an NF-kappa_b-independent mechanism .
8639787	0	Interleukin-4	0,13	vascular_cell_adhesion_molecule-1	101,134	Interleukin-4	vascular cell adhesion molecule-1	3565	7412	Gene	Gene	START_ENTITY|acl|mediating mediating|dobj|induction induction|amod|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular_cell_adhesion_molecule-1 induction in the absence of the common_gamma_chain .
9569232	0	Interleukin-4	0,13	vascular_cell_adhesion_molecule-1	57,90	Interleukin-4	vascular cell adhesion molecule-1	3565	7412	Gene	Gene	synergize|nsubj|START_ENTITY synergize|xcomp|induce induce|dobj|expression expression|amod|END_ENTITY	Interleukin-4 and lipopolysaccharide synergize to induce vascular_cell_adhesion_molecule-1 expression in human lung microvascular endothelial cells .
11149012	0	Interleukin-4	0,13	vascular_endothelial_growth_factor	51,85	Interleukin-4	vascular endothelial growth factor	3565	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Interleukin-4 inhibits the increased production of vascular_endothelial_growth_factor by peripheral blood mononuclear cells in patients with inflammatory_bowel_disease .
16407046	0	Interleukin-4_and_13	0,20	interleukin-6	94,107	Interleukin-4 and 13	interleukin-6	3565;3596	3569	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Interleukin-4_and_13 induce the expression and release of monocyte_chemoattractant_protein_1 , interleukin-6 and stem_cell_factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha .
16407046	0	Interleukin-4_and_13	0,20	monocyte_chemoattractant_protein_1	58,92	Interleukin-4 and 13	monocyte chemoattractant protein 1	3565;3596	6347	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Interleukin-4_and_13 induce the expression and release of monocyte_chemoattractant_protein_1 , interleukin-6 and stem_cell_factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha .
23940537	0	Interleukin-5	0,13	CD4	119,122	Interleukin-5	CD4	3567	920	Gene	Gene	supports|nsubj|START_ENTITY supports|dobj|expansion expansion|acl:relcl|induce induce|dobj|cells cells|compound|apoptosis apoptosis|nmod|T T|compound|END_ENTITY	Interleukin-5 supports the expansion of fas_ligand-expressing killer B cells that induce antigen-specific apoptosis of CD4 -LRB- + -RRB- T cells and secrete interleukin-10 .
8648029	0	Interleukin-5	0,13	CD4	59,62	Interleukin-5	CD4	3567	920	Gene	Gene	messenger|amod|START_ENTITY RNA|nsubj|messenger RNA|nmod|cells cells|compound|END_ENTITY	Interleukin-5 messenger RNA expression in peripheral blood CD4 + cells in asthma .
7819742	0	Interleukin-5	0,13	intercellular_adhesion_molecule-1	26,59	Interleukin-5	intercellular adhesion molecule-1	3567	3383	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Interleukin-5 upregulates intercellular_adhesion_molecule-1 gene expression in the nasal mucosa in nasal_allergy but not in nonallergic rhinitis .
22324945	0	Interleukin-6	0,13	ADAMTS-4	40,48	Interleukin-6	ADAMTS-4	3569	9507	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid_arthritis .
17785926	0	Interleukin-6	35,48	C-Reactive_Protein	91,109	Interleukin-6	C-Reactive Protein	3569	1401	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|nmod|Concentrations Concentrations|compound|END_ENTITY	Effects of the Interaction between Interleukin-6 -634 C/G Polymorphism and Smoking on Serum C-Reactive_Protein Concentrations .
25748492	0	Interleukin-6	106,119	C-reactive_Protein	0,18	Interleukin-6	C-reactive Protein	3569	1401	Gene	Gene	Up-regulated|nmod|START_ENTITY Up-regulated|nsubj|Expression Expression|compound|END_ENTITY	C-reactive_Protein Expression Is Up-regulated in Apical Lesions of Endodontic Origin in Association with Interleukin-6 .
14993508	0	Interleukin-6	0,13	C-reactive_protein	81,99	Interleukin-6	C-reactive protein	3569	1401	Gene	Gene	predictor|nsubj|START_ENTITY predictor|nmod|END_ENTITY	Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive_protein in haemodialysis patients .
17374948	0	Interleukin-6	0,13	C-reactive_protein	15,33	Interleukin-6	C-reactive protein	3569	1401	Gene	Gene	START_ENTITY|appos|parameters parameters|amod|END_ENTITY	Interleukin-6 , C-reactive_protein and biochemical parameters during prolonged intermittent fasting .
18285696	0	Interleukin-6	0,13	C-reactive_protein	64,82	Interleukin-6	C-reactive protein	3569	1401	Gene	Gene	predictor|nsubj|START_ENTITY predictor|nmod|mortality mortality|acl|products products|amod|END_ENTITY	Interleukin-6 is a better predictor of mortality as compared to C-reactive_protein , homocysteine , pentosidine and advanced oxidation protein products in hemodialysis patients .
19626399	0	Interleukin-6	0,13	C-reactive_protein	69,87	Interleukin-6	C-reactive protein	3569	1401	Gene	Gene	predictor|nsubj|START_ENTITY predictor|nmod|END_ENTITY	Interleukin-6 is a stronger prognostic predictor than high-sensitive C-reactive_protein in patients with chronic stable heart_failure .
21190868	0	Interleukin-6	0,13	C-reactive_protein	122,140	Interleukin-6	C-reactive protein	3569	1401	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients : comparison with C-reactive_protein .
8658073	0	Interleukin-6	0,13	C-reactive_protein	15,33	Interleukin-6	C-reactive protein	3569	1401	Gene	Gene	count|advmod|START_ENTITY count|nsubj|cell cell|compound|lactoferrin lactoferrin|amod|END_ENTITY	Interleukin-6 , C-reactive_protein , lactoferrin and white blood cell count in patients with S. _ aureus_septicemia .
18389078	0	Interleukin-6	0,13	CD4	65,68	Interleukin-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nsubj|START_ENTITY cells|amod|crucial crucial|nmod|recall recall|nmod|T T|compound|END_ENTITY	Interleukin-6 is crucial for recall of influenza-specific memory CD4 T cells .
19959384	0	Interleukin-6	0,13	CX3CR1	33,39	Interleukin-6	CX3CR1	24498(Tax:10116)	171056(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-6 induces microglial CX3CR1 expression in the spinal cord after peripheral nerve_injury through the activation of p38 MAPK .
25333344	0	Interleukin-6	0,13	CYP1B1	39,45	Interleukin-6	CYP1B1	3569	1545	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal_cancer involves DNA methylation , miR27b and STAT3 .
24378454	0	Interleukin-6	0,13	Gp130	55,60	Interleukin-6	Gp130	24498(Tax:10116)	25205(Tax:10116)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|dobj|neuronal_death neuronal_death|nmod|inhibition inhibition|amod|END_ENTITY	Interleukin-6 prevents NMDA-induced neuronal_death via Gp130 signaling-dependent IP3R inhibition .
10377335	0	Interleukin-6	0,13	IL-6	71,75	Interleukin-6	IL-6	3569	3569	Gene	Gene	production|amod|START_ENTITY production|dep|regulation regulation|nmod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- production by astrocytes : autocrine regulation by IL-6 and the soluble IL-6 receptor .
1381679	0	Interleukin-6	0,13	IL-6	15,19	Interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- gene expression and secretion by cytokine-stimulated human retinal pigment epithelial cells .
14521945	0	Interleukin-6	0,13	IL-6	87,91	Interleukin-6	IL-6	3569	3569	Gene	Gene	production|amod|START_ENTITY production|dep|regulation regulation|nmod|END_ENTITY	Interleukin-6 production by contracting human skeletal muscle : autocrine regulation by IL-6 .
15081444	0	Interleukin-6	0,13	IL-6	15,19	Interleukin-6	IL-6	3569	3569	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- expression and natural killer -LRB- NK -RRB- cell dysfunction and anergy in heart_failure .
22695063	0	Interleukin-6	0,13	IL-6	20,24	Interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin-6 gene -LRB- IL-6 -RRB- : a possible role in brain morphology in the healthy adult brain .
7632810	0	Interleukin-6	0,13	IL-6	15,19	Interleukin-6	IL-6	3569	3569	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- levels in febrile children during maximal aplasia after bone marrow transplantation -LRB- BMT -RRB- are similar to those in children with normal hematopoiesis .
12952969	0	Interleukin-6	0,13	IL-8_and_tumor_necrosis_factor-alpha	82,118	Interleukin-6	IL-8 and tumor necrosis factor-alpha	3569	3576;7124	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- induces insulin resistance in 3T3-L1 adipocytes and is , like IL-8_and_tumor_necrosis_factor-alpha , overexpressed in human fat cells from insulin-resistant subjects .
14764608	0	Interleukin-6	0,13	Ifi202	36,42	Interleukin-6	Ifi202	16193(Tax:10090)	26388(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 induces expression of Ifi202 , an interferon-inducible candidate gene for lupus susceptibility .
21461291	0	Interleukin-6	45,58	Insulin	15,22	Interleukin-6	Insulin	3569	3630	Gene	Gene	Resistance|nmod|START_ENTITY Resistance|nsubj|Association Association|nmod|END_ENTITY	Association of Insulin Resistance with Serum Interleukin-6 and TNF-a Levels During Normal Pregnancy .
17184847	0	Interleukin-6	154,167	Interleukin-1beta	53,70	Interleukin-6	Interleukin-1beta	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	level|nmod|START_ENTITY effect|nmod|level infected|nmod|effect mice|acl|infected END_ENTITY|nmod|mice	Interleukin-10 reduces hyperalgesia and the level of Interleukin-1beta in BALB/c mice infected with Leishmania_major with no major effect on the level of Interleukin-6 .
16820800	0	Interleukin-6	0,13	KDR	40,43	Interleukin-6	KDR	3569	3791	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells .
10198259	0	Interleukin-6	0,13	Kip1	57,61	Interleukin-6	Kip1	3569	1027	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	Interleukin-6 induces G1 arrest through induction of p27 -LRB- Kip1 -RRB- , a cyclin-dependent kinase inhibitor , and neuron-like morphology in LNCaP prostate_tumor cells .
10894816	0	Interleukin-6	0,13	LDL_receptor	25,37	Interleukin-6	LDL receptor	3569	3949	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Interleukin-6 stimulates LDL_receptor gene expression via activation of sterol-responsive and Sp1 binding elements .
20122990	0	Interleukin-6	0,13	PMP22	44,49	Interleukin-6	PMP22	24498(Tax:10116)	24660(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 upregulates the expression of PMP22 in cultured rat Schwann cells via a JAK2-dependent pathway .
22962574	0	Interleukin-6	0,13	S100A9	22,28	Interleukin-6	S100A9	3569	6280	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative_colitis .
24242046	0	Interleukin-6	0,13	STAT1/3	126,133	Interleukin-6	STAT1/3	3569	6772;6774	Gene	Gene	inhibition|amod|START_ENTITY mediated|nsubjpass|inhibition mediated|nmod|END_ENTITY	Interleukin-6 inhibition of peroxisome_proliferator-activated_receptor_alpha expression is mediated by JAK2 - and PI3K-induced STAT1/3 in HepG2 hepatocyte cells .
12629515	0	Interleukin-6	0,13	STAT3	82,87	Interleukin-6	STAT3	3569	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|angiogenesis angiogenesis|nmod|pathway pathway|compound|END_ENTITY	Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway .
12665506	0	Interleukin-6	0,13	STAT3	73,78	Interleukin-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	family|amod|START_ENTITY mediates|nsubj|family mediates|dobj|activation activation|compound|END_ENTITY	Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart .
12865171	0	Interleukin-6	0,13	STAT3	58,63	Interleukin-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|translocation translocation|compound|END_ENTITY	Interleukin-6 mediates lipopolysaccharide-induced nuclear STAT3 translocation in astrocytes of rat sensory circumventricular organs .
14586407	0	Interleukin-6	0,13	STAT3	113,118	Interleukin-6	STAT3	3569	6774	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|activation activation|nmod|END_ENTITY	Interleukin-6 acts as an antiapoptotic factor in human esophageal_carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways .
15532800	0	Interleukin-6	0,13	STAT3	91,96	Interleukin-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	augments|amod|START_ENTITY augments|dep|involvement involvement|nmod|activation activation|compound|END_ENTITY	Interleukin-6 augments hepatocyte_growth_factor-induced liver_regeneration ; involvement of STAT3 activation .
16835372	0	Interleukin-6	0,13	STAT3	50,55	Interleukin-6	STAT3	3569	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin-6 induces hepcidin expression through STAT3 .
17581928	0	Interleukin-6	0,13	STAT3	88,93	Interleukin-6	STAT3	3569	6774	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|involvement involvement|nmod|END_ENTITY	Interleukin-6 stimulates alpha-MG uptake in renal proximal tubule cells : involvement of STAT3 , PI3K/Akt , MAPKs , and NF-kappaB .
19020307	0	Interleukin-6	0,13	STAT3	14,19	Interleukin-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Interleukin-6 / STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities .
21954831	0	Interleukin-6	0,13	STAT3	78,83	Interleukin-6	STAT3	3569	6774	Gene	Gene	autocrine|nsubj|START_ENTITY mediates|dep|autocrine mediates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Interleukin-6 autocrine signaling mediates melatonin MT -LRB- 1/2 -RRB- receptor-induced STAT3 Tyr -LRB- 705 -RRB- phosphorylation .
22962574	0	Interleukin-6	0,13	STAT3	76,81	Interleukin-6	STAT3	3569	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nummod|END_ENTITY	Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative_colitis .
23114963	0	Interleukin-6	0,13	STAT3	92,97	Interleukin-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|differentiation differentiation|dep|role role|nmod|pathway pathway|compound|END_ENTITY	Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells : role of the STAT3 pathway .
25968456	0	Interleukin-6	0,13	STAT3	14,19	Interleukin-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|parataxis|Drives Drives|nsubj|Signaling Signaling|compound|END_ENTITY	Interleukin-6 / STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma .
25968456	0	Interleukin-6	0,13	STAT3	14,19	Interleukin-6	STAT3	3569	6774	Gene	Gene	START_ENTITY|parataxis|Drives Drives|nsubj|Signaling Signaling|compound|END_ENTITY	Interleukin-6 / STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma .
26663388	0	Interleukin-6	0,13	STAT3	85,90	Interleukin-6	STAT3	3569	6774	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Interleukin-6 increases expression of serine_protease_inhibitor_Kazal_type_1 through STAT3 in colorectal_adenocarcinoma .
8617307	0	Interleukin-6	0,13	Shc	77,80	Interleukin-6	Shc	3569	6464	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc , and its complex formation with Grb2 in the human multiple myeloma cell line LP-1 .
15176047	0	Interleukin-6	0,13	Stat3	94,99	Interleukin-6	Stat3	3569	6774	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|acl|induced induced|nmod|pathway pathway|amod|END_ENTITY	Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway .
22522232	0	Interleukin-6	0,13	Stat3	81,86	Interleukin-6	Stat3	100628202	733648(Tax:9823)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Interleukin-6 enhances porcine parthenote development in vitro , through the IL-6 / Stat3 signaling pathway .
18176176	0	Interleukin-6	0,13	TNF-alpha	51,60	Interleukin-6	TNF-alpha	3569	7124	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
8858917	0	Interleukin-6	0,13	Trk	67,70	Interleukin-6	Trk	24498(Tax:10116)	59109(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|receptor receptor|compound|END_ENTITY	Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signaling to promote neuronal differentiation in PC12 cells .
15863613	0	Interleukin-6	0,13	Zip14	45,50	Interleukin-6	Zip14	16193(Tax:10090)	213053(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response .
11410519	0	Interleukin-6	0,13	androgen_receptor	96,113	Interleukin-6	androgen receptor	3569	367	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Interleukin-6 induces androgen responsiveness in prostate_cancer cells through up-regulation of androgen_receptor expression .
12431817	0	Interleukin-6	0,13	androgen_receptor	24,41	Interleukin-6	androgen receptor	3569	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Interleukin-6 regulates androgen_receptor activity and prostate_cancer cell growth .
12763015	0	Interleukin-6	0,13	androgen_receptor	39,56	Interleukin-6	androgen receptor	3569	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transactivation transactivation|compound|END_ENTITY	Interleukin-6 differentially regulates androgen_receptor transactivation via PI3K-Akt , STAT3 , and MAPK , three distinct signal pathways in prostate_cancer cells .
17373716	0	Interleukin-6	0,13	androgen_receptor	133,150	Interleukin-6	androgen receptor	3569	367	Gene	Gene	undergoes|nsubj|START_ENTITY undergoes|nmod|inhibitor inhibitor|acl|associated associated|nmod|stimulator stimulator|acl|accompanied accompanied|nmod|activation activation|compound|END_ENTITY	Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen_receptor activation during LNCaP_prostate_cancer cell progression .
19011039	0	Interleukin-6	0,13	androgen_receptor	102,119	Interleukin-6	androgen receptor	3569	367	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|activation activation|nmod|END_ENTITY	Interleukin-6 stimulation of growth of prostate_cancer in vitro and in vivo through activation of the androgen_receptor .
9788616	0	Interleukin-6	0,13	androgen_receptor	110,127	Interleukin-6	androgen receptor	3569	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Interleukin-6 regulates prostate-specific protein expression in prostate_carcinoma cells by activation of the androgen_receptor .
1901940	0	Interleukin-6	0,13	c-myc	157,162	Interleukin-6	c-myc	3569	4609	Gene	Gene	differentiation|amod|START_ENTITY blocked|nsubjpass|differentiation blocked|nmod|END_ENTITY	Interleukin-6 - and leukemia_inhibitory_factor-induced terminal differentiation of myeloid_leukemia cells is blocked at an intermediate stage by constitutive c-myc .
2346497	0	Interleukin-6	0,13	c-myc	25,30	Interleukin-6	c-myc	3569	4609	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Interleukin-6 stimulates c-myc expression and proliferation of cultured vascular smooth muscle cells .
10761792	0	Interleukin-6	0,13	carcinoembryonic_antigen	57,81	Interleukin-6	carcinoembryonic antigen	3569	1084	Gene	Gene	level|amod|START_ENTITY associated|nsubjpass|level associated|advcl|circulating circulating|dobj|END_ENTITY	Interleukin-6 blood level is associated with circulating carcinoembryonic_antigen and prognosis in patients with colorectal_cancer .
1477074	0	Interleukin-6	0,13	carcinoembryonic_antigen	24,48	Interleukin-6	carcinoembryonic antigen	3569	1084	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Interleukin-6 increases carcinoembryonic_antigen and histocompatibility leukocyte antigen expression on the surface of human colorectal_carcinoma cells .
20110692	0	Interleukin-6	0,13	cathepsin_B	52,63	Interleukin-6	cathepsin B	3569	1508	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 increases expression and secretion of cathepsin_B by breast_tumor-associated monocytes .
21771795	0	Interleukin-6	0,13	claudin-2	31,40	Interleukin-6	claudin-2	3569	9075	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- regulates claudin-2 expression and tight junction permeability in intestinal epithelium .
24662742	0	Interleukin-6	0,13	claudin-2	119,128	Interleukin-6	claudin-2	16193(Tax:10090)	12738(Tax:10090)	Gene	Gene	modulation|amod|START_ENTITY mediated|nsubjpass|modulation mediated|nmod|activation activation|nmod|gene gene|amod|END_ENTITY	Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene .
8391424	0	Interleukin-6	0,13	corticosteroid-binding_globulin	23,54	Interleukin-6	corticosteroid-binding globulin	3569	866	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Interleukin-6 inhibits corticosteroid-binding_globulin synthesis by human hepatoblastoma-derived -LRB- Hep G2 -RRB- cells .
1819551	0	Interleukin-6	0,13	gonadotropin-releasing_hormone	25,55	Interleukin-6	gonadotropin-releasing hormone	24498(Tax:10116)	25194(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Interleukin-6 stimulates gonadotropin-releasing_hormone secretion from rat hypothalamic cells .
10025579	0	Interleukin-6	0,13	gp130	151,156	Interleukin-6	gp130	3569	3572	Gene	Gene	decreased|nsubjpass|START_ENTITY decreased|nmod|major_depression major_depression|dep|alteration alteration|nmod|END_ENTITY	Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major_depression : no alteration of soluble gp130 .
2788034	0	Interleukin-6	0,13	gp130	90,95	Interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	triggers|nsubj|START_ENTITY triggers|nmod|transducer transducer|appos|END_ENTITY	Interleukin-6 triggers the association of its receptor with a possible signal transducer , gp130 .
8662918	0	Interleukin-6	0,13	gp130	96,101	Interleukin-6	gp130	3569	3572	Gene	Gene	family|amod|START_ENTITY expressed|nsubj|family expressed|nmod|protein protein|amod|END_ENTITY	Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein .
9490696	0	Interleukin-6	0,13	granulocyte_colony-stimulating_factor	93,130	Interleukin-6	granulocyte colony-stimulating factor	3569	1440	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Interleukin-6 production by human neutrophils after Fc-receptor cross-linking or exposure to granulocyte_colony-stimulating_factor .
12519742	0	Interleukin-6	0,13	growth_hormone	31,45	Interleukin-6	growth hormone	16193(Tax:10090)	14599(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interleukin-6 inhibits hepatic growth_hormone signaling via upregulation of Cis and Socs-3 .
11397854	0	Interleukin-6	0,13	haptoglobin	40,51	Interleukin-6	haptoglobin	3569	3240	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Interleukin-6 differentially stimulates haptoglobin production by peritoneal and endometriotic cells in vitro : a model for endometrial-peritoneal interaction in endometriosis .
10856890	0	Interleukin-6	0,13	insulin	24,31	Interleukin-6	insulin	3569	3630	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Interleukin-6 increases insulin secretion and preproinsulin mRNA expression via Ca2 + - dependent mechanism .
2404746	0	Interleukin-6	0,13	insulin	22,29	Interleukin-6	insulin	24498(Tax:10116)	3630	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|secretion secretion|compound|END_ENTITY	Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro .
1792940	0	Interleukin-6	0,13	interleukin-1	131,144	Interleukin-6	interleukin-1	3569	3552	Gene	Gene	expression|compound|START_ENTITY expression|dep|regulation regulation|nmod|END_ENTITY	Interleukin-6 messenger RNA expression and interleukin-6 protein secretion in cells isolated from normal human bone : regulation by interleukin-1 .
1918169	0	Interleukin-6	0,13	interleukin-1	101,114	Interleukin-6	interleukin-1	3569	3552	Gene	Gene	production|amod|START_ENTITY production|dep|regulation regulation|nmod|END_ENTITY	Interleukin-6 production by the blast cells of acute_myeloblastic_leukemia : regulation by endogenous interleukin-1 and biological implications .
25109676	0	Interleukin-6	0,13	interleukin-1	15,28	Interleukin-6	interleukin-1	3569	3552	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Interleukin-6 , interleukin-1 gene cluster and interleukin-1_receptor polymorphisms in Iranian patients with juvenile systemic_lupus_erythematosus .
8819122	0	Interleukin-6	0,13	interleukin-1	83,96	Interleukin-6	interleukin-1	3569	3552	Gene	Gene	production|amod|START_ENTITY production|dep|regulation regulation|nmod|END_ENTITY	Interleukin-6 production and secretion in human melanoma cell lines : regulation by interleukin-1 .
17346426	0	Interleukin-6	0,13	interleukin-10	15,29	Interleukin-6	interleukin-10	3569	3586	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Interleukin-6 , interleukin-10 and heat_shock protein-90 expression in renal_epithelial_neoplasias and surrounding normal-appearing renal_parenchyma .
19762082	0	Interleukin-6	0,13	interleukin-10	23,37	Interleukin-6	interleukin-10	3569	3586	Gene	Gene	leads|nsubj|START_ENTITY leads|nmod|production production|amod|END_ENTITY	Interleukin-6 leads to interleukin-10 production in several human multiple_myeloma cell lines .
23566695	0	Interleukin-6	0,13	interleukin-1_beta	15,33	Interleukin-6	interleukin-1 beta	3569	3553	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Interleukin-6 , interleukin-1_beta and interleukin-1_receptor_antagonist levels in epileptic_seizures .
1715237	0	Interleukin-6	0,13	interleukin-2	31,44	Interleukin-6	interleukin-2	3569	3558	Gene	Gene	support|nsubj|START_ENTITY support|dobj|generation generation|compound|END_ENTITY	Interleukin-6 does not support interleukin-2 induced generation of human lymphokine-activated killer cells .
12423307	0	Interleukin-6	0,13	interleukin-4	41,54	Interleukin-6	interleukin-4	3569	3565	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|nmod|END_ENTITY	Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and - independent mechanisms in freshly isolated human T cells .
2469502	0	Interleukin-6	0,13	interleukin-4	29,42	Interleukin-6	interleukin-4	16193(Tax:10090)	16189(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic , erythroid , myeloid , and multipotential progenitor cells .
21467819	0	Interleukin-6	0,13	interleukin-6	26,39	Interleukin-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Interleukin-6 and soluble interleukin-6 receptor suppress osteoclastic differentiation by inducing PGE -LRB- 2 -RRB- production in chondrocytes .
23375410	0	Interleukin-6	0,13	interleukin-6	96,109	Interleukin-6	interleukin-6	3569	3569	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Interleukin-6 in the pathogenesis of posterior capsule opacification and the potential role for interleukin-6 inhibition in the future of cataract surgery .
25245339	0	Interleukin-6	0,13	interleukin-6	46,59	Interleukin-6	interleukin-6	3569	3569	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	Interleukin-6 , soluble interleukin-6_receptor / interleukin-6 complex and insulin resistance in obese children and adolescents .
8770701	0	Interleukin-6	0,13	interleukin-6	26,39	Interleukin-6	interleukin-6	3569	16193(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid_arthritis patients are responsible for osteoclast-like cell formation .
16056242	0	Interleukin-6	0,13	interleukin-6_receptor	22,44	Interleukin-6	interleukin-6 receptor	24498(Tax:10116)	24499(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|reduces reduces|nsubj|complex complex|amod|END_ENTITY	Interleukin-6 / soluble interleukin-6_receptor complex reduces infarct size via inhibiting myocardial_apoptosis .
16690760	0	Interleukin-6	0,13	interleukin-6_receptor	104,126	Interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	signalling|amod|START_ENTITY limited|nsubjpass|signalling limited|nmod|END_ENTITY	Interleukin-6 signalling in juvenile_idiopathic_arthritis is limited by proteolytically cleaved soluble interleukin-6_receptor .
18980999	0	Interleukin-6	0,13	interleukin-6_receptor	26,48	Interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Interleukin-6 and soluble interleukin-6_receptor levels as markers of disease extent and prognosis in neuroblastoma .
22591418	0	Interleukin-6	0,13	interleukin-6_receptor	14,36	Interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	START_ENTITY|parataxis|target target|nsubj|pathway pathway|amod|END_ENTITY	Interleukin-6 / interleukin-6_receptor pathway as a new therapy target in epithelial_ovarian_cancer .
24695006	0	Interleukin-6	0,13	interleukin-6_receptor	26,48	Interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Interleukin-6 and soluble interleukin-6_receptor levels in posttraumatic_stress_disorder : associations with lifetime diagnostic status and psychological context .
24702712	0	Interleukin-6	0,13	interleukin-6_receptor	38,60	Interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|glucose glucose|amod|END_ENTITY	Interleukin-6 in combination with the interleukin-6_receptor stimulates glucose uptake in resting human skeletal muscle independently of insulin action .
26725994	0	Interleukin-6	0,13	interleukin-6_receptor	15,37	Interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	START_ENTITY|appos|dementia dementia|amod|END_ENTITY	Interleukin-6 , interleukin-6_receptor gene variant , small-vessel_disease and incident dementia .
23791833	0	Interleukin-6	0,13	paraoxonase_1	26,39	Interleukin-6	paraoxonase 1	3569	5444	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Interleukin-6 upregulates paraoxonase_1 gene expression via an AKT/NF-kB-dependent pathway .
10379905	0	Interleukin-6	0,13	parathyroid_hormone	44,63	Interleukin-6	parathyroid hormone	280826(Tax:9913)	280903(Tax:9913)	Gene	Gene	induced|nsubj|START_ENTITY induced|dobj|suppression suppression|nmod|secretion secretion|compound|END_ENTITY	Interleukin-6 induced suppression of bovine parathyroid_hormone secretion .
8858917	0	Interleukin-6	0,13	peripherin	36,46	Interleukin-6	peripherin	24498(Tax:10116)	24688(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signaling to promote neuronal differentiation in PC12 cells .
17616429	0	Interleukin-6	0,13	peroxisome_proliferator_activated_receptor_alpha	29,77	Interleukin-6	peroxisome proliferator activated receptor alpha	3569	5465	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Interleukin-6 inhibits human peroxisome_proliferator_activated_receptor_alpha gene expression via CCAAT/enhancer-binding proteins in hepatocytes .
8033820	0	Interleukin-6	0,13	placental_lactogen	25,43	Interleukin-6	placental lactogen	3569	1443	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Interleukin-6 stimulates placental_lactogen expression by human trophoblast cells .
8613706	0	Interleukin-6	0,13	platelet-activating_factor	50,76	Interleukin-6	platelet-activating factor	3569	9768	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Interleukin-6 stimulates neutrophil production of platelet-activating_factor .
10924340	0	Interleukin-6	0,13	pregnane_X_receptor	53,72	Interleukin-6	pregnane X receptor	3569	8856	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 negatively regulates the expression of pregnane_X_receptor and constitutively_activated_receptor in primary human hepatocytes .
17324931	0	Interleukin-6	0,13	prohibitin	42,52	Interleukin-6	prohibitin	3569	5245	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells .
26663388	0	Interleukin-6	0,13	serine_protease_inhibitor_Kazal_type_1	38,76	Interleukin-6	serine protease inhibitor Kazal type 1	3569	6690	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Interleukin-6 increases expression of serine_protease_inhibitor_Kazal_type_1 through STAT3 in colorectal_adenocarcinoma .
16840717	0	Interleukin-6	0,13	signal_transducer_and_activator_of_transcription_3	58,108	Interleukin-6	signal transducer and activator of transcription 3	3569	6774	Gene	Gene	induction|amod|START_ENTITY regulated|nsubjpass|induction regulated|nmod|END_ENTITY	Interleukin-6 induction of protein s is regulated through signal_transducer_and_activator_of_transcription_3 .
24168060	0	Interleukin-6	0,13	signal_transducer_and_activator_of_transcription_3	119,169	Interleukin-6	signal transducer and activator of transcription 3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|ccomp|stem stem|nmod|signaling signaling|nmod|END_ENTITY	Interleukin-6 induces malignant transformation of rat mesenchymal stem cells in association with enhanced signaling of signal_transducer_and_activator_of_transcription_3 .
10639195	0	Interleukin-6	0,13	stat3	79,84	Interleukin-6	stat3	3569	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|growth growth|acl|accompanied accompanied|nmod|activation activation|nmod|END_ENTITY	Interleukin-6 induces prostate_cancer cell growth accompanied by activation of stat3 signaling pathway .
11166453	0	Interleukin-6	0,13	stem_cell_factor	60,76	Interleukin-6	stem cell factor	3569	17311(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Interleukin-6 and the soluble interleukin-6 receptor induce stem_cell_factor and Flt-3L expression in vivo and in vitro .
10841078	0	Interleukin-6	0,13	thrombopoietin	24,38	Interleukin-6	thrombopoietin	3569	7066	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Interleukin-6 increases thrombopoietin production in human hepatoma cells HepG2 and Hep3B .
11716039	0	Interleukin-6	0,13	thyrotropin_receptor	25,45	Interleukin-6	thyrotropin receptor	3569	7253	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Interleukin-6 stimulates thyrotropin_receptor expression in human orbital preadipocyte fibroblasts from patients with Graves ' _ ophthalmopathy .
11892999	0	Interleukin-6	0,13	transforming_growth_factor-alpha	23,55	Interleukin-6	transforming growth factor-alpha	3569	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Interleukin-6 enhances transforming_growth_factor-alpha mRNA expression in macrophage-like human monocytoid -LRB- U-937-1 -RRB- cells .
1524837	0	Interleukin-6	0,13	tumor_necrosis_factor	51,72	Interleukin-6	tumor necrosis factor	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|mice mice|amod|lethality lethality|nmod|END_ENTITY	Interleukin-6 is a better marker of lethality than tumor_necrosis_factor in endotoxin treated mice .
1653625	0	Interleukin-6	0,13	tumor_necrosis_factor	41,62	Interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|receptors receptors|compound|END_ENTITY	Interleukin-6 enhances the expression of tumor_necrosis_factor receptors on hepatoma cells and hepatocytes .
2192263	0	Interleukin-6	0,13	tumor_necrosis_factor	27,48	Interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Interleukin-6 induction by tumor_necrosis_factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence .
8274730	0	Interleukin-6	0,13	tumor_necrosis_factor	117,138	Interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	START_ENTITY|dep|induction induction|acl|circulating circulating|dobj|p55 p55|compound|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- as an anti-inflammatory cytokine : induction of circulating IL-1_receptor_antagonist and soluble tumor_necrosis_factor receptor p55 .
1601643	0	Interleukin-6	0,13	tumor_necrosis_factor-alpha	69,96	Interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	prime|nsubj|START_ENTITY prime|nmod|production production|nmod|END_ENTITY	Interleukin-6 can prime THP-1 macrophages for enhanced production of tumor_necrosis_factor-alpha in response to LPS .
18176176	0	Interleukin-6	0,13	tumor_necrosis_factor-alpha	22,49	Interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
8386026	0	Interleukin-6	0,13	tumor_necrosis_factor-alpha	100,127	Interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|acl:relcl|induced induced|nmod|beta beta|amod|END_ENTITY	Interleukin-6 inhibits the proliferation of B-chronic_lymphocytic_leukemia cells that is induced by tumor_necrosis_factor-alpha or - beta .
11426961	0	Interleukin-6	0,13	vascular_endothelial_growth_factor	56,90	Interleukin-6	vascular endothelial growth factor	3569	7422	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Interleukin-6 in cervical_cancer : the relationship with vascular_endothelial_growth_factor .
15153787	0	Interleukin-6	0,13	vascular_endothelial_growth_factor	24,58	Interleukin-6	vascular endothelial growth factor	3569	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Interleukin-6 increases vascular_endothelial_growth_factor and angiogenesis in gastric_carcinoma .
15688401	0	Interleukin-6	0,13	vascular_endothelial_growth_factor	52,86	Interleukin-6	vascular endothelial growth factor	16193(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Interleukin-6 induces transcriptional activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1 .
23219526	0	Interleukin-6	0,13	vascular_endothelial_growth_factor	22,56	Interleukin-6	vascular endothelial growth factor	3569	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin-6 induces vascular_endothelial_growth_factor expression and promotes angiogenesis through apoptosis_signal-regulating_kinase_1 in human osteosarcoma .
10497240	0	Interleukin-6_and_leukemia_inhibitory_factor	0,44	JunB	58,62	Interleukin-6 and leukemia inhibitory factor	JunB	16193;16878	16477(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Interleukin-6_and_leukemia_inhibitory_factor induction of JunB is regulated by distinct cell type-specific cis-acting elements .
11177576	0	Interleukin-6_and_transforming_growth_factor-beta_1	0,51	cathepsins_B_and_L	74,92	Interleukin-6 and transforming growth factor-beta 1	cathepsins B and L	3569;7040	1508;1514	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin-6_and_transforming_growth_factor-beta_1 control expression of cathepsins_B_and_L in human lung epithelial cells .
15837717	0	Interleukin-6_receptor	0,22	IL-6	91,95	Interleukin-6 receptor	IL-6	3570	3569	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Interleukin-6_receptor expression in contracting human skeletal muscle : regulating role of IL-6 .
20186139	0	Interleukin-6_receptor	0,22	interleukin-6	51,64	Interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	polymorphism|amod|START_ENTITY modulates|nsubj|polymorphism modulates|dobj|levels levels|amod|END_ENTITY	Interleukin-6_receptor gene polymorphism modulates interleukin-6 levels and the metabolic_syndrome : GBCS-CVD .
19933849	0	Interleukin-7	0,13	Bim	24,27	Interleukin-7	Bim	16196(Tax:10090)	12125(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival .
8938103	0	Interleukin-7	0,13	CD23	43,47	Interleukin-7	CD23	3574	2208	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|compound|END_ENTITY	Interleukin-7 modulates intracytoplasmatic CD23 production and induces adhesion molecule expression and adhesiveness in activated CD4 + CD23 + T cell subsets .
16380489	0	Interleukin-7	0,13	CD25	44,48	Interleukin-7	CD25	16196(Tax:10090)	16184(Tax:10090)	Gene	Gene	factor|nsubj|START_ENTITY factor|nmod|T-cells T-cells|compound|END_ENTITY	Interleukin-7 is a survival factor for CD4 + CD25 + T-cells and is expressed by diabetes-suppressive_dendritic_cells .
25485946	0	Interleukin-7	0,13	CD25	96,100	Interleukin-7	CD25	16196(Tax:10090)	16184(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY +|nsubj|CD4 +|nmod|Expression Expression|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
11581400	0	Interleukin-7	0,13	CD4	40,43	Interleukin-7	CD4	3574	920	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|depletion depletion|compound|END_ENTITY	Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human_immunodeficiency_virus_type_1-positive individuals .
15720434	0	Interleukin-7	0,13	CD4	86,89	Interleukin-7	CD4	3574	920	Gene	Gene	signalling|amod|START_ENTITY sufficient|nsubj|signalling sufficient|nmod|cells cells|amod|naive naive|advmod|END_ENTITY	Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells .
16380489	0	Interleukin-7	0,13	CD4	39,42	Interleukin-7	CD4	16196(Tax:10090)	12504(Tax:10090)	Gene	Gene	factor|nsubj|START_ENTITY factor|nmod|T-cells T-cells|compound|END_ENTITY	Interleukin-7 is a survival factor for CD4 + CD25 + T-cells and is expressed by diabetes-suppressive_dendritic_cells .
17855550	0	Interleukin-7	0,13	CD4	88,91	Interleukin-7	CD4	3574	920	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|ve ve|dobj|cells cells|nummod|END_ENTITY	Interleukin-7 enhances proliferation responses to T-cell receptor stimulation in na ve CD4 + T cells from human_immunodeficiency_virus-infected persons .
20167604	0	Interleukin-7	0,13	CD4	75,78	Interleukin-7	CD4	3574	920	Gene	Gene	compartmentalizes|nsubj|START_ENTITY compartmentalizes|xcomp|signaling signaling|xcomp|complex complex|xcomp|initiate initiate|dobj|response response|compound|END_ENTITY	Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response .
20465565	0	Interleukin-7	0,13	CD4	45,48	Interleukin-7	CD4	3574	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|nmod|END_ENTITY	Interleukin-7 promotes the survival of human CD4 + effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway .
22586481	0	Interleukin-7	0,13	CD4	31,34	Interleukin-7	CD4	16196(Tax:10090)	12504(Tax:10090)	Gene	Gene	influences|nsubj|START_ENTITY influences|xcomp|cells cells|nsubj|+ +|compound|END_ENTITY	Interleukin-7 influences FOXP3 + CD4 + regulatory T cells peripheral homeostasis .
23215679	0	Interleukin-7	0,13	CD4	64,67	Interleukin-7	CD4	16196(Tax:10090)	12504(Tax:10090)	Gene	Gene	supports|nsubj|START_ENTITY supports|xcomp|thymocytes thymocytes|nsubj|survival survival|nmod|CD8 CD8|compound|END_ENTITY	Interleukin-7 supports survival of T-cell_receptor-b-expressing CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- double-negative thymocytes .
26319414	0	Interleukin-7	0,13	CD4	30,33	Interleukin-7	CD4	3574	920	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|T T|compound|END_ENTITY	Interleukin-7 is required for CD4 -LRB- + -RRB- T cell activation and autoimmune_neuroinflammation .
26965634	0	Interleukin-7	0,13	CD4	66,69	Interleukin-7	CD4	3574	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|development development|nmod|stage stage|compound|END_ENTITY	Interleukin-7 promotes human regulatory T cell development at the CD4 + CD8 + double-positive thymocyte stage .
9079802	0	Interleukin-7	0,13	CD4	36,39	Interleukin-7	CD4	3574	920	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|compound|END_ENTITY	Interleukin-7 activates human naive CD4 + cells and primes for interleukin-4 production .
26965634	0	Interleukin-7	0,13	CD8	70,73	Interleukin-7	CD8	3574	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|development development|nmod|stage stage|compound|END_ENTITY	Interleukin-7 promotes human regulatory T cell development at the CD4 + CD8 + double-positive thymocyte stage .
22586481	0	Interleukin-7	0,13	FOXP3	25,30	Interleukin-7	FOXP3	16196(Tax:10090)	20371(Tax:10090)	Gene	Gene	influences|nsubj|START_ENTITY influences|xcomp|cells cells|nsubj|+ +|compound|END_ENTITY	Interleukin-7 influences FOXP3 + CD4 + regulatory T cells peripheral homeostasis .
25485946	0	Interleukin-7	0,13	FOXP3	24,29	Interleukin-7	FOXP3	16196(Tax:10090)	20371(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|compound|END_ENTITY	Interleukin-7 Optimizes FOXP3 + CD4 + Regulatory T Cells Reactivity to Interleukin-2 by Modulating CD25 Expression .
21413939	0	Interleukin-7	0,13	FoxP3	103,108	Interleukin-7	FoxP3	3574	50943	Gene	Gene	matures|nsubj|START_ENTITY T|dep|matures T|nmod|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
21413939	0	Interleukin-7	0,13	FoxP3	60,65	Interleukin-7	FoxP3	3574	50943	Gene	Gene	matures|nsubj|START_ENTITY matures|dobj|forkhead_box_P3 forkhead_box_P3|appos|END_ENTITY	Interleukin-7 matures suppressive CD127 -LRB- + -RRB- forkhead_box_P3 -LRB- FoxP3 -RRB- -LRB- + -RRB- T cells into CD127 -LRB- - -RRB- CD25 -LRB- high -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
24528037	0	Interleukin-7	0,13	IFN-gamma	104,113	Interleukin-7	IFN-gamma	16196(Tax:10090)	15978(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|induction induction|nmod|END_ENTITY	Interleukin-7 enhances the in vivo anti-tumor activity of tumor-reactive CD8 + T cells with induction of IFN-gamma in a murine breast_cancer model .
1730410	0	Interleukin-7	0,13	N-myc	22,27	Interleukin-7	N-myc	3574	4613	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes .
9203963	0	Interleukin-7	0,13	interferon-gamma	96,112	Interleukin-7	interferon-gamma	16196(Tax:10090)	15978(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|decrease decrease|nmod|production production|amod|END_ENTITY	Interleukin-7 in the skin of Schistosoma_mansoni-infected mice is associated with a decrease in interferon-gamma production and leads to an aggravation of the disease .
15207247	0	Interleukin-8	0,13	AP-1	116,120	Interleukin-8	AP-1	3576	3727	Gene	Gene	production|amod|START_ENTITY mediated|nsubjpass|production mediated|nmod|pathways pathways|compound|END_ENTITY	Interleukin-8 production by THP-1 cells stimulated by Salmonella_enterica_serovar_Typhimurium porins is mediated by AP-1 , NF-kappaB and MAPK pathways .
12687191	0	Interleukin-8	70,83	C-Reactive_Protein	16,34	Interleukin-8	C-Reactive Protein	3576	1401	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of C-Reactive_Protein and Serum_Amyloid_P_Component with Interleukin-8 and Their Role in Regulation of Neutrophil Functions .
15545974	0	Interleukin-8	0,13	CXCL8	14,19	Interleukin-8	CXCL8	3576	3576	Gene	Gene	START_ENTITY|parataxis|factor factor|nsubj|END_ENTITY	Interleukin-8 / CXCL8 is a growth factor for human lung_cancer cells .
12738812	0	Interleukin-8	0,13	CXCR1	112,117	Interleukin-8	CXCR1	3576	3577	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1 .
25944115	0	Interleukin-8	111,124	CXCR1	78,83	Interleukin-8	CXCR1	280828(Tax:9913)	281863(Tax:9913)	Gene	Gene	incubation|compound|START_ENTITY genotype|dobj|incubation genotype|nsubj|generation generation|nmod|neutrophils neutrophils|nmod|END_ENTITY	Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 -LRB- IL8RA -RRB- genotype following Interleukin-8 incubation .
25944115	0	Interleukin-8	111,124	CXCR1	78,83	Interleukin-8	CXCR1	280828(Tax:9913)	281863(Tax:9913)	Gene	Gene	incubation|compound|START_ENTITY genotype|dobj|incubation genotype|nsubj|generation generation|nmod|neutrophils neutrophils|nmod|END_ENTITY	Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 -LRB- IL8RA -RRB- genotype following Interleukin-8 incubation .
26065367	0	Interleukin-8	0,13	CXCR1	73,78	Interleukin-8	CXCR1	20309(Tax:10090)	227288(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Interleukin-8 Induces Expression of FOXC1 to Promote Trans-activation of CXCR1 and CCL2 in Hepatocellular_Carcinoma Cell Lines and Formation of Metastases in Mice .
19967052	0	Interleukin-8	30,43	ERK	9,12	Interleukin-8	ERK	3576	5594	Gene	Gene	Expression|compound|START_ENTITY Roles|nmod|Expression Roles|nmod|END_ENTITY	Roles of ERK and NF-kappaB in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells .
18472935	0	Interleukin-8	89,102	Endothelin-1	0,12	Interleukin-8	Endothelin-1	3576	1906	Gene	Gene	Identified|nmod|START_ENTITY vitro|nmod|Identified Monocytes|advcl|vitro Monocytes|nsubj|Stimulates Stimulates|compound|END_ENTITY	Endothelin-1 Stimulates Monocytes in vitro to Release Chemotactic Activity Identified as Interleukin-8 and Monocyte_Chemotactic_Protein-1 .
26065367	0	Interleukin-8	0,13	FOXC1	36,41	Interleukin-8	FOXC1	20309(Tax:10090)	17300(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Interleukin-8 Induces Expression of FOXC1 to Promote Trans-activation of CXCR1 and CCL2 in Hepatocellular_Carcinoma Cell Lines and Formation of Metastases in Mice .
25239884	0	Interleukin-8	61,74	SMAR1	29,34	Interleukin-8	SMAR1	3576	54971	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Chromatin remodeling protein SMAR1 regulates NF-kB dependent Interleukin-8 transcription in breast_cancer .
14767470	0	Interleukin-8	0,13	Src	115,118	Interleukin-8	Src	20309(Tax:10090)	20779(Tax:10090)	Gene	Gene	confers|nsubj|START_ENTITY confers|dobj|growth growth|dep|effects effects|nmod|END_ENTITY	Interleukin-8 confers androgen-independent growth and migration of LNCaP : differential effects of tyrosine kinases Src and FAK .
15207247	0	Interleukin-8	0,13	THP-1	28,33	Interleukin-8	THP-1	3576	2736	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Interleukin-8 production by THP-1 cells stimulated by Salmonella_enterica_serovar_Typhimurium porins is mediated by AP-1 , NF-kappaB and MAPK pathways .
25411513	0	Interleukin-8	38,51	Thyrotropin_Receptor	0,20	Interleukin-8	Thyrotropin Receptor	3576	7253	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Thyrotropin_Receptor and CD40 Mediate Interleukin-8 Expression in Fibrocytes : Implications for Thyroid-Associated_Ophthalmopathy -LRB- An American Ophthalmological Society Thesis -RRB- .
12524080	0	Interleukin-8	0,13	interleukin-1beta	62,79	Interleukin-8	interleukin-1beta	3576	3553	Gene	Gene	gene|amod|START_ENTITY up-regulated|nsubj|gene up-regulated|advcl|END_ENTITY	Interleukin-8 gene and protein expression are up-regulated by interleukin-1beta in normal human ovarian cells and a granulosa tumor cell line .
20373993	0	Interleukin-8	0,13	interleukin-1beta	15,32	Interleukin-8	interleukin-1beta	100620730	396565(Tax:9823)	Gene	Gene	linked|advmod|START_ENTITY linked|nsubjpass|END_ENTITY	Interleukin-8 , interleukin-1beta , and interferon-gamma levels are linked to PRRS virus clearance .
8277774	0	Interleukin-8	0,13	interleukin-2	62,75	Interleukin-8	interleukin-2	20309(Tax:10090)	16183(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|effect effect|nmod|END_ENTITY	Interleukin-8 suppresses the toxicity and antitumor effect of interleukin-2 .
8205398	0	Interleukin-8	0,13	interleukin-4	116,129	Interleukin-8	interleukin-4	3576	3565	Gene	Gene	secretion|amod|START_ENTITY secretion|dep|effects effects|nmod|END_ENTITY	Interleukin-8 secretion and 15-lipoxygenase activity in rheumatoid_arthritis : in vitro anti-inflammatory effects by interleukin-4 and interleukin-10 , but not by interleukin-1_receptor_antagonist_protein .
17203209	0	Interleukin-8	0,13	protease-activated_receptor_2	29,58	Interleukin-8	protease-activated receptor 2	3576	2150	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Interleukin-8 production via protease-activated_receptor_2 in human esophageal epithelial cells .
14527339	0	Interleukin-8	0,13	syndecan-2	23,33	Interleukin-8	syndecan-2	3576	6383	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Interleukin-8 binds to syndecan-2 on human endothelial cells .
21271591	0	Interleukin-8	0,13	tumor_necrosis_factor-alpha	40,67	Interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	production|amod|START_ENTITY production|acl|END_ENTITY	Interleukin-8 production in response to tumor_necrosis_factor-alpha by cholesteatoma keratinocytes in cell culture .
8228354	0	Interleukin-8	0,13	tumor_necrosis_factor-alpha	78,105	Interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|nmod|response response|nmod|END_ENTITY	Interleukin-8 production by human peritoneal mesothelial cells in response to tumor_necrosis_factor-alpha , interleukin-1 , and medium conditioned by macrophages cocultured with Staphylococcus_epidermidis .
18307536	0	Interleukin-8	0,13	vascular_endothelial_growth_factor	24,58	Interleukin-8	vascular endothelial growth factor	3576	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Interleukin-8 increases vascular_endothelial_growth_factor and neuropilin expression and stimulates ERK activation in human pancreatic_cancer .
11282560	0	Interleukin-9	0,13	24P3	22,26	Interleukin-9	24P3	16198(Tax:10090)	16819(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Interleukin-9 induces 24P3 lipocalin gene expression in murine T_cell_lymphomas .
16266865	0	Interleukin-9	0,13	interleukin-5	43,56	Interleukin-9	interleukin-5	16198(Tax:10090)	16191(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|cells cells|amod|END_ENTITY	Interleukin-9 stimulates the production of interleukin-5 in CD4 + T cells .
3275721	0	Interleukin_1	0,13	CD1	22,25	Interleukin 1	CD1	3552	911	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin_1 induces CD1 antigen expression on human gingival epithelial cells .
8830657	0	Interleukin_1	0,13	JNK1	47,51	Interleukin 1	JNK1	3552	5599	Gene	Gene	activates|nsubj|START_ENTITY activates|ccomp|kinases kinases|dobj|END_ENTITY	Interleukin_1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase -LRB- ERK -RRB- in human glomerular mesangial cells .
1386364	0	Interleukin_1	0,13	NF-kappa_B	22,32	Interleukin 1	NF-kappa B	111343(Tax:10090)	18033(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin_1 induces NF-kappa_B through its type I but not its type II receptor in lymphocytes .
8806690	0	Interleukin_1	0,13	c-Met	65,70	Interleukin 1	c-Met	111343(Tax:10090)	17295(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Interleukin_1 induces an autocrine loop hepatocyte_growth_factor / c-Met in murine Kaposi-like spindle cells .
3298430	0	Interleukin_1	0,13	granulocyte-macrophage_colony-stimulating_factor	60,108	Interleukin 1	granulocyte-macrophage colony-stimulating factor	3552	1437	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|produce produce|dobj|END_ENTITY	Interleukin_1 stimulates human endothelial cells to produce granulocyte-macrophage_colony-stimulating_factor and granulocyte_colony-stimulating_factor .
3491839	0	Interleukin_1	0,13	granulocyte-macrophage_colony-stimulating_factor	68,116	Interleukin 1	granulocyte-macrophage colony-stimulating factor	3552	1437	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Interleukin_1 induces cultured human endothelial cell production of granulocyte-macrophage_colony-stimulating_factor .
1898777	0	Interleukin_1	0,13	heparin-binding_growth_factor_2	24,55	Interleukin 1	heparin-binding growth factor 2	3552	2247	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Interleukin_1 regulates heparin-binding_growth_factor_2 gene expression in vascular smooth muscle cells .
2542734	0	Interleukin_1	0,13	interleukin_2	28,41	Interleukin 1	interleukin 2	3552	3558	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|activation activation|amod|END_ENTITY	Interleukin_1 regulation of interleukin_2 and interferon-gamma gene activation in a human leukemic HSB .2 subclone .
2578047	0	Interleukin_1	0,13	interleukin_2	115,128	Interleukin 1	interleukin 2	3552	3558	Gene	Gene	production|amod|START_ENTITY requires|nsubj|production requires|xcomp|distinct distinct|nmod|END_ENTITY	Interleukin_1 production by the human monocyte cell line U937 requires a lymphokine induction signal distinct from interleukin_2 or interferons .
3490673	0	Interleukin_1	0,13	platelet_activating_factor	25,51	Interleukin 1	platelet activating factor	3552	9768	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Interleukin_1 stimulates platelet_activating_factor production in cultured human endothelial cells .
3109496	0	Interleukin_1	0,13	tissue-type_plasminogen_activator	58,91	Interleukin 1	tissue-type plasminogen activator	3552	5327	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Interleukin_1 preferentially stimulates the production of tissue-type_plasminogen_activator by human articular chondrocytes .
22853041	0	Interleukin_1-beta	0,18	brain-derived_neurotrophic_factor	31,64	Interleukin 1-beta	brain-derived neurotrophic factor	3553	627	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Interleukin_1-beta upregulates brain-derived_neurotrophic_factor , neurotrophin_3 and neuropilin_2 gene expression and NGF production in annulus cells .
26557732	0	Interleukin_10	61,75	CD38	141,145	Interleukin 10	CD38	3586	952	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Effect of Stress-Free Therapy on immune system : Induction of Interleukin_10 expression in lymphocytes through activation of CD19 -LRB- + -RRB- CD24 -LRB- hi -RRB- CD38 -LRB- hi -RRB- regulatory B Cells .
26603204	0	Interleukin_10	126,140	CXCR2	89,94	Interleukin 10	CXCR2	16153(Tax:10090)	12765(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|compound|END_ENTITY	Toll-like_Receptor_4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin_10 During Intra-abdominal_Sepsis .
8711645	0	Interleukin_10	0,14	IL-10	16,21	Interleukin 10	IL-10	3586	3586	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- regulation of tumour necrosis factor alpha -LRB- TNF-alpha -RRB- from human alveolar macrophages and peripheral blood monocytes .
9918218	0	Interleukin_10	0,14	IL-10	16,21	Interleukin 10	IL-10	3586	3586	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- inhibition of primary human prostate cell-induced angiogenesis : IL-10 stimulation of tissue inhibitor of metalloproteinase-1 and inhibition of matrix_metalloproteinase _ -LRB- MMP -RRB- -2 / MMP-9 secretion .
20714339	0	Interleukin_10	0,14	MICA	25,29	Interleukin 10	MICA	3586	100507436	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Interleukin_10 decreases MICA expression on melanoma cell surface .
10484681	0	Interleukin_10	0,14	TNF-alpha	24,33	Interleukin 10	TNF-alpha	3586	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin_10 inhibits TNF-alpha production in human monocytes independently of interleukin 12 and interleukin_1_beta .
26603204	0	Interleukin_10	126,140	Toll-like_Receptor_4	0,20	Interleukin 10	Toll-like Receptor 4	16153(Tax:10090)	21898(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Suppresses|xcomp|Expression Suppresses|nsubj|Signaling Signaling|compound|END_ENTITY	Toll-like_Receptor_4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin_10 During Intra-abdominal_Sepsis .
8092983	0	Interleukin_10	0,14	elastin	28,35	Interleukin 10	elastin	3586	2006	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Interleukin_10 up-regulates elastin gene expression in vivo and in vitro at the transcriptional level .
8596138	0	Interleukin_10	0,14	interleukin_4	31,44	Interleukin 10	interleukin 4	3586	3565	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Interleukin_10 cooperates with interleukin_4 to suppress inflammatory cytokine production by freshly prepared adherent rheumatoid synovial cells .
8744678	0	Interleukin_10	0,14	interleukin_6	24,37	Interleukin 10	interleukin 6	3586	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin_10 inhibits interleukin_6 production and acute phase response in rheumatoid_arthritis .
9041534	0	Interleukin_10	0,14	vascular_permeability_factor	24,52	Interleukin 10	vascular permeability factor	3586	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Interleukin_10 inhibits vascular_permeability_factor release by peripheral blood mononuclear cells in patients with lipoid_nephrosis .
20232770	0	Interleukin_10_receptor_alpha_subunit	0,37	IL-10RA	39,46	Interleukin 10 receptor alpha subunit	IL-10RA	3587	3587	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin_10_receptor_alpha_subunit -LRB- IL-10RA -RRB- gene polymorphism and IL-10 serum levels in Egyptian atopic patients .
20068108	0	Interleukin_13	0,14	interleukin_13_receptor_alpha2	52,82	Interleukin 13	interleukin 13 receptor alpha2	3596	3598	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Interleukin_13 mediates signal transduction through interleukin_13_receptor_alpha2 in pancreatic_ductal_adenocarcinoma : role of IL-13 Pseudomonas exotoxin in pancreatic_cancer therapy .
8810643	0	Interleukin_13	0,14	macrophage_inflammatory_protein-1_alpha	24,63	Interleukin 13	macrophage inflammatory protein-1 alpha	3596	6348	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin_13 inhibits macrophage_inflammatory_protein-1_alpha production from human alveolar macrophages and monocytes .
12589789	0	Interleukin_15	0,14	ERK	70,73	Interleukin 15	ERK	3600	5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin_15 induces the signals of epidermal proliferation through ERK and PI 3-kinase in a human epidermal keratinocyte cell line , HaCaT .
11237433	0	Interleukin_15	0,14	matrix_metalloproteinase-9_and_tissue_inhibitor_of_metalloproteinase-1	40,110	Interleukin 15	matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1	3600	4318	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|cells cells|amod|END_ENTITY	Interleukin_15 stimulates production of matrix_metalloproteinase-9_and_tissue_inhibitor_of_metalloproteinase-1 by human peripheral blood mononuclear cells .
26161406	0	Interleukin_16	0,14	IL-16	17,22	Interleukin 16	IL-16	3603	3603	Gene	Gene	-|compound|START_ENTITY -|dep|END_ENTITY	Interleukin_16 - -LRB- IL-16 - -RRB- Targeted Ultrasound Imaging Agent Improves Detection of Ovarian_Tumors in Laying Hens , a Preclinical Model of Spontaneous Ovarian_Cancer .
11709514	0	Interleukin_16	0,14	interleukin_16	43,57	Interleukin 16	interleukin 16	3603	3603	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Interleukin_16 expression and phenotype of interleukin_16 producing cells in Crohn 's _ disease .
12064845	0	Interleukin_17	0,14	IL-17	167,172	Interleukin 17	IL-17	3605	3605	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Interleukin_17 -LRB- IL-17 -RRB- induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation : differential activation of AP-1 members by IL-17 and IL-1beta .
23220496	0	Interleukin_17_receptor_A	50,75	IL17RA	77,83	Interleukin 17 receptor A	IL17RA	23765	23765	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of single nucleotide polymorphisms on Interleukin_17_receptor_A -LRB- IL17RA -RRB- gene with aspirin hypersensitivity in asthmatics .
9413156	0	Interleukin_18	0,14	Fas_ligand	24,34	Interleukin 18	Fas ligand	3606	356	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Interleukin_18 enhances Fas_ligand expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells .
10998752	0	Interleukin_18	0,14	IL-18	16,21	Interleukin 18	IL-18	3606	3606	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Interleukin_18 -LRB- IL-18 -RRB- levels in patients with sepsis .
23557801	0	Interleukin_18	0,14	IL18	16,20	Interleukin 18	IL18	3606	3606	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Interleukin_18 -LRB- IL18 -RRB- gene promoter polymorphisms are associated with type_1_diabetes_mellitus in Brazilian patients .
18514661	0	Interleukin_18	0,14	lectin-like_oxidized_LDL_receptor-1	45,80	Interleukin 18	lectin-like oxidized LDL receptor-1	3606	4973	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Interleukin_18 stimulates release of soluble lectin-like_oxidized_LDL_receptor-1 -LRB- sLOX-1 -RRB- .
25422961	0	Interleukin_1B	0,14	IL1B	21,25	Interleukin 1B	IL1B	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin_1B gene -LRB- IL1B -RRB- variation and internalizing symptoms in maltreated preschoolers .
9284748	0	Interleukin_1_alpha	0,19	leptin	36,42	Interleukin 1 alpha	leptin	3552	3952	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|concentrations concentrations|compound|END_ENTITY	Interleukin_1_alpha increases serum leptin concentrations in humans .
23442095	0	Interleukin_1_beta	15,33	IL-1B	35,40	Interleukin 1 beta	IL-1B	3553	3553	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of Interleukin_1_beta -LRB- IL-1B -RRB- gene polymorphism with early pregnancy_loss risk in the North Indian population .
16860880	0	Interleukin_1_beta	0,18	interleukin_11	33,47	Interleukin 1 beta	interleukin 11	3553	3589	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Interleukin_1_beta is induced by interleukin_11 during decidualization of human endometrial stromal cells , but is not released in a bioactive form .
7917907	0	Interleukin_1_beta	0,18	interleukin_2	35,48	Interleukin 1 beta	interleukin 2	3553	3558	Gene	Gene	synergises|nsubj|START_ENTITY synergises|nmod|END_ENTITY	Interleukin_1_beta synergises with interleukin_2 in the outgrowth of autologous_tumour-reactive CD8 + effectors .
7768376	0	Interleukin_1_beta	0,18	interleukin_6	45,58	Interleukin 1 beta	interleukin 6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Interleukin_1_beta induces the expression of interleukin_6 in rat intestinal smooth muscle cells .
25341731	0	Interleukin_1_receptor-associated_kinase_1	0,42	IRAK1	44,49	Interleukin 1 receptor-associated kinase 1	IRAK1	3654	3654	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Interleukin_1_receptor-associated_kinase_1 -LRB- IRAK1 -RRB- mutation is a common , essential driver for Kaposi_sarcoma herpesvirus_lymphoma .
14699442	0	Interleukin_1alpha	0,18	IL-1alpha	20,29	Interleukin 1alpha	IL-1alpha	16175(Tax:10090)	16175(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	Interleukin_1alpha -LRB- IL-1alpha -RRB- induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function .
9828188	0	Interleukin_1alpha	0,18	lactate_dehydrogenase_A	30,53	Interleukin 1alpha	lactate dehydrogenase A	3552	3939	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Interleukin_1alpha stimulates lactate_dehydrogenase_A expression and lactate production in cultured porcine sertoli cells .
16435917	0	Interleukin_1beta	0,17	IL1B	19,23	Interleukin 1beta	IL1B	16176(Tax:10090)	16176(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Interleukin_1beta -LRB- IL1B -RRB- signaling is a critical component of radiation-induced skin fibrosis .
10510091	0	Interleukin_2	0,13	CD4	107,110	Interleukin 2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	reverse|nsubj|START_ENTITY reverse|dobj|defect defect|nmod|generation generation|nmod|cells cells|compound|END_ENTITY	Interleukin_2 , but not other common gamma chain-binding cytokines , can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice .
12235217	0	Interleukin_2	0,13	CD4	40,43	Interleukin 2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling required|nmod|function function|amod|END_ENTITY	Interleukin_2 signaling is required for CD4 -LRB- + -RRB- regulatory T cell function .
25629163	0	Interleukin_2	73,86	CD4	104,107	Interleukin 2	CD4	3558	920	Gene	Gene	Transcription|compound|START_ENTITY Transcription|nmod|Cells Cells|compound|END_ENTITY	Inhibition of G-Protein by Signaling Enhances T Cell Receptor-Stimulated Interleukin_2 Transcription in CD4 + T Helper Cells .
2575597	0	Interleukin_2	0,13	CD4	51,54	Interleukin 2	CD4	3558	920	Gene	Gene	production|amod|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Interleukin_2 production by alloantigen-stimulated CD4 + and CD8 + human T cell subsets : frequency of HLA class I or class II-reactive precursor cells and clonal specificity of activated T cells .
7479922	0	Interleukin_2	0,13	CD4	102,105	Interleukin 2	CD4	3558	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|suppression suppression|nmod|replication replication|nmod|cells cells|compound|END_ENTITY	Interleukin_2 induces CD8 + T cell-mediated suppression of human immunodeficiency virus replication in CD4 + T cells and this effect overrides its ability to stimulate virus expression .
1850360	0	Interleukin_2	0,13	CD45	51,55	Interleukin 2	CD45	16183(Tax:10090)	19264(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin_2 stimulates serine phosphorylation of CD45 in CTLL-2 .4 cells .
6175428	0	Interleukin_2	0,13	IFN_gamma	68,77	Interleukin 2	IFN gamma	3558	3458	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Interleukin_2 regulation of mitogen induction of immune_interferon -LRB- IFN_gamma -RRB- in spleen cells and thymocytes .
6231106	0	Interleukin_2	0,13	IL-2	15,19	Interleukin 2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- activity during tumor growth : IL-2 production kinetics , absorption of and responses to exogenous IL-2 .
2338453	0	Interleukin_2	0,13	IL_2	15,19	Interleukin 2	IL 2	3558	3558	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Interleukin_2 -LRB- IL_2 -RRB- inhibitor in rheumatoid synovial fluid : correlation with prognosis and soluble IL_2 receptor levels .
8525770	0	Interleukin_2	1,14	Il-2	25,29	Interleukin 2	Il-2	3558	3558	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- Interleukin_2 receptor -LRB- Il-2 -RRB- : structure and function -RSB- .
3493642	0	Interleukin_2	1,14	S-antigen	29,38	Interleukin 2	S-antigen	116562(Tax:10116)	25539(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	-LSB- Interleukin_2 production in S-antigen immunized rats and effects of cyclosporine -RSB- .
6092510	0	Interleukin_2	0,13	Tac_antigen	42,53	Interleukin 2	Tac antigen	3558	3559	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin_2 regulates the expression of Tac_antigen on peripheral blood T lymphocytes .
6408175	0	Interleukin_2	0,13	gamma-interferon	22,38	Interleukin 2	gamma-interferon	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Interleukin_2 induces gamma-interferon production : participation of macrophages and NK-like cells .
3097133	0	Interleukin_2	0,13	interferon-gamma	27,43	Interleukin 2	interferon-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|synthesis synthesis|amod|END_ENTITY	Interleukin_2 induction of interferon-gamma mRNA synthesis .
3121725	0	Interleukin_2	0,13	interferon-gamma	43,59	Interleukin 2	interferon-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	Interleukin_2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways .
3000665	2	Interleukin_2	39,52	interleukin_2	127,140	Interleukin 2	interleukin 2	3558	3558	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin_2 receptor_and_transferrin_receptor expression on T cells and production of interleukin_2 in patients with acquired_immune_deficiency_syndrome -LRB- AIDS -RRB- and AIDS-related_complex .
8200459	0	Interleukin_2	0,13	p72syk	23,29	Interleukin 2	p72syk	3558	6850	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Interleukin_2 mediates p72syk activation in peripheral blood lymphocytes .
2106566	0	Interleukin_2	0,13	p75	71,74	Interleukin 2	p75	3558	3560	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- - induced tyrosine phosphorylation of IL-2_receptor p75 .
1691263	0	Interleukin_2	0,13	pore-forming_protein	27,47	Interleukin 2	pore-forming protein	3558	5551	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Interleukin_2 induction of pore-forming_protein gene expression in human peripheral blood CD8 + T cells .
3000665	2	Interleukin_2	39,52	receptor_and_transferrin_receptor	53,86	Interleukin 2	receptor and transferrin receptor	3558	3558	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Interleukin_2 receptor_and_transferrin_receptor expression on T cells and production of interleukin_2 in patients with acquired_immune_deficiency_syndrome -LRB- AIDS -RRB- and AIDS-related_complex .
1937586	0	Interleukin_2	0,13	tumor_necrosis_factor	22,43	Interleukin 2	tumor necrosis factor	16183(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin_2 induces tumor_necrosis_factor gene expression in vivo .
23250909	0	Interleukin_23	0,14	interleukin-23_receptor	117,140	Interleukin 23	interleukin-23 receptor	27178	149233	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Interleukin_23 regulates proliferation of lung_cancer cells in a concentration-dependent way in association with the interleukin-23_receptor .
25718332	1	Interleukin_27	14,28	IL-27	30,35	Interleukin 27	IL-27	246778	246778	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Interleukin_27 -LRB- IL-27 -RRB- in the Colonic Mucosa of Patients with Inflammatory_Bowel_Disease .
26905929	0	Interleukin_27	19,33	IL-27	35,40	Interleukin 27	IL-27	246778	246778	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Protective role of Interleukin_27 -LRB- IL-27 -RRB- gene polymorphisms in patients with ulcerative_colitis .
23029250	0	Interleukin_27	0,14	complement_factor_H	41,60	Interleukin 27	complement factor H	246778	3075	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin_27 induces the expression of complement_factor_H -LRB- CFH -RRB- in the retina .
21847628	0	Interleukin_29	0,14	Toll_receptor_3	38,53	Interleukin 29	Toll receptor 3	282618	7098	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Interleukin_29 enhances expression of Toll_receptor_3 and mediates antiviral signals in human keratinocytes .
11222392	0	Interleukin_3	0,13	BCR/ABL	169,176	Interleukin 3	BCR/ABL	16187(Tax:10090)	110279;11350	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Interleukin_3 and granulocyte-macrophage_colony-stimulating_factor are not required for induction of chronic_myeloid_leukemia-like_myeloproliferative_disease in mice by BCR/ABL .
8630039	0	Interleukin_3	0,13	JAK2	33,37	Interleukin 3	JAK2	16187(Tax:10090)	16452(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Interleukin_3 activates not only JAK2 and STAT5 , but also Tyk2 , STAT1 , and STAT3 .
7651724	0	Interleukin_3	0,13	Vav	55,58	Interleukin 3	Vav	3562	7409	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	Interleukin_3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain .
3923475	0	Interleukin_3	0,13	erythropoietin	93,107	Interleukin 3	erythropoietin	16187(Tax:10090)	13856(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Interleukin_3 promotes erythroid burst formation in `` serum-free '' cultures without detectable erythropoietin .
24459820	0	Interleukin_33	0,14	tumor_necrosis_factor_alpha	29,56	Interleukin 33	tumor necrosis factor alpha	77125(Tax:10090)	21926(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Interleukin_33 is induced by tumor_necrosis_factor_alpha and interferon_gamma in keratinocytes and contributes to allergic_contact_dermatitis .
26316892	0	Interleukin_37	0,14	STAT3	35,40	Interleukin 37	STAT3	27178	6774	Gene	Gene	Inhibits|compound|START_ENTITY END_ENTITY|nsubj|Inhibits	Interleukin_37 Expression Inhibits STAT3 to Suppress the Proliferation and Invasion of Human Cervical_Cancer Cells .
22197009	0	Interleukin_4	0,13	CCR9	24,28	Interleukin 4	CCR9	416330(Tax:9031)	428454(Tax:9031)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Interleukin_4 increases CCR9 expression and homing of lymphocytes to gut-associated lymphoid tissue in chickens .
1701391	0	Interleukin_4	0,13	CD14	47,51	Interleukin 4	CD14	3565	929	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin_4 down-regulates the expression of CD14 in normal human monocytes .
1725131	0	Interleukin_4	0,13	CD14	47,51	Interleukin 4	CD14	3565	929	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Interleukin_4 down-regulates the expression of CD14 and the production of interleukin_6 in acute_myeloid_leukemia cells .
1826374	0	Interleukin_4	0,13	CD4	62,65	Interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Interleukin_4 and interferon_gamma production in restimulated CD4 + and CD8 + cells indicates memory type responsiveness .
1970729	0	Interleukin_4	0,13	CD4	22,25	Interleukin 4	CD4	3565	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	Interleukin_4	0,13	CD4	40,43	Interleukin 4	CD4	3565	920	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
7869030	0	Interleukin_4	0,13	CD4	28,31	Interleukin 4	CD4	3565	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|nummod|END_ENTITY	Interleukin_4 production by CD4 + T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type .
1970729	0	Interleukin_4	0,13	CD8	27,30	Interleukin 4	CD8	3565	925	Gene	Gene	+|compound|START_ENTITY +|dep|CD4 CD4|dep|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1970729	0	Interleukin_4	0,13	CD8	35,38	Interleukin 4	CD8	3565	925	Gene	Gene	+|compound|START_ENTITY +|dep|CD4 CD4|dep|CD8 CD8|nmod|+ +|compound|END_ENTITY	Interleukin_4 induces CD4 + / CD8 - to CD8 + / CD4 - transformation of human neonatal T cells by way of a double positive intermediate .
1905643	0	Interleukin_4	0,13	CD8_alpha	22,31	Interleukin 4	CD8 alpha	16189(Tax:10090)	12525(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin_4 induces CD8_alpha expression on T cell receptor V gamma 5 thymocytes .
7608118	0	Interleukin_4	0,13	GD3	35,38	Interleukin 4	GD3	3565	117189	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Interleukin_4 enhances ganglioside GD3 expression on the human fibroblast cell line WI-38 .
2901096	0	Interleukin_4	0,13	Thy-1	31,36	Interleukin 4	Thy-1	16189(Tax:10090)	21838(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Interleukin_4 induces membrane Thy-1 expression on normal murine B cells .
8519688	0	Interleukin_4	0,13	c-kit	43,48	Interleukin 4	c-kit	3565	3815	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin_4 down-regulates expression of c-kit and autocrine stem_cell_factor in human colorectal_carcinoma cells .
1899386	0	Interleukin_4	0,13	interferon-gamma	82,98	Interleukin 4	interferon-gamma	3565	3458	Gene	Gene	induces|nsubj|START_ENTITY induces|parataxis|synergy synergy|nmod|END_ENTITY	Interleukin_4 induces interleukin_6 production by endothelial cells : synergy with interferon-gamma .
1900240	1	Interleukin_4	63,76	interferon-gamma	93,109	Interleukin 4	interferon-gamma	16189(Tax:10090)	15978(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Interleukin_4 synergizes with interferon-gamma to activate murine macrophages for killing of Leishmania_major_amastigotes .
1679715	0	Interleukin_4	0,13	interleukin_4	143,156	Interleukin 4	interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Interleukin_4 receptor targeted cytotoxicity : genetic construction and in vivo immunosuppressive activity of a diphtheria toxin-related murine interleukin_4 fusion protein .
1899386	0	Interleukin_4	0,13	interleukin_6	22,35	Interleukin 4	interleukin 6	3565	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Interleukin_4 induces interleukin_6 production by endothelial cells : synergy with interferon-gamma .
2677211	0	Interleukin_4	0,13	interleukin_6	46,59	Interleukin 4	interleukin 6	3565	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Interleukin_4 induces selective production of interleukin_6 from normal human B lymphocytes .
16139999	0	Interleukin_4	0,13	lysyl_hydroxylase_2	71,90	Interleukin 4	lysyl hydroxylase 2	3565	5352	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Interleukin_4 and prolonged hypoxia induce a higher gene expression of lysyl_hydroxylase_2 and an altered cross-link pattern : important pathogenetic steps in early and late stage of systemic_scleroderma ?
8519688	0	Interleukin_4	0,13	stem_cell_factor	63,79	Interleukin 4	stem cell factor	3565	4254	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Interleukin_4 down-regulates expression of c-kit and autocrine stem_cell_factor in human colorectal_carcinoma cells .
8200916	0	Interleukin_4	0,13	type_5_acid_phosphatase	24,47	Interleukin 4	type 5 acid phosphatase	16189(Tax:10090)	11433(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Interleukin_4 increases type_5_acid_phosphatase mRNA expression in murine bone marrow macrophages .
1394231	0	Interleukin_4_receptor	0,22	interleukin_4	86,99	Interleukin 4 receptor	interleukin 4	3566	3565	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin_4_receptor expression and growth inhibition of gastric_carcinoma cells by interleukin_4 .
9448048	0	Interleukin_5	0,13	Shc	30,33	Interleukin 5	Shc	3567	6464	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Interleukin_5 signals through Shc and Grb2 in human eosinophils .
3262706	0	Interleukin_5	0,13	interleukin_4	47,60	Interleukin 5	interleukin 4	3567	3565	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Interleukin_5 and interleukin_2 cooperate with interleukin_4 to induce IgG1 secretion from anti-Ig-treated B cells .
23257175	0	Interleukin_6	0,13	C-reactive_protein	49,67	Interleukin 6	C-reactive protein	3569	1401	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|synthesis synthesis|amod|END_ENTITY	Interleukin_6 augments mechanical strain-induced C-reactive_protein synthesis via the stretch-activated channel-nuclear factor k B signal pathway .
8525439	0	Interleukin_6	0,13	IL-6	15,19	Interleukin 6	IL-6	3569	3569	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Interleukin_6 -LRB- IL-6 -RRB- levels in the monitoring of surgical trauma .
1623561	0	Interleukin_6	0,13	c-sis	24,29	Interleukin 6	c-sis	3569	5155	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Interleukin_6 modulates c-sis gene expression in cultured human endothelial cells .
8425178	0	Interleukin_6	0,13	endothelin_1	58,70	Interleukin 6	endothelin 1	3569	1906	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Interleukin_6 stimulates the production of immunoreactive endothelin_1 in human breast_cancer cells .
7487347	1	Interleukin_6	35,48	interleukin_1	90,103	Interleukin 6	interleukin 1	3569	3552	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Interleukin_6 produced by activated thymocytes induces interleukin_1 production by macrophages .
2107652	0	Interleukin_6	0,13	interleukin_1_beta	34,52	Interleukin 6	interleukin 1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Interleukin_6 possibly induced by interleukin_1_beta in the pituitary gland stimulates the release of gonadotropins and prolactin .
12357369	0	Interleukin_6	0,13	monocyte_chemoattractant_protein-1	22,56	Interleukin 6	monocyte chemoattractant protein-1	3569	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Interleukin_6 induces monocyte_chemoattractant_protein-1 expression in myeloma cells .
16317687	0	Interleukin_6	0,13	myeloid_cell_leukemia-1	26,49	Interleukin 6	myeloid cell leukemia-1	3569	4170	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Interleukin_6 upregulates myeloid_cell_leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells .
24531714	0	Interleukin_6	0,13	p53	28,31	Interleukin 6	p53	3569	7157	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Interleukin_6 downregulates p53 expression and activity by stimulating ribosome biogenesis : a new pathway connecting inflammation to cancer .
26566817	0	Interleukin_6	0,13	p63	33,36	Interleukin 6	p63	3569	8626	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Interleukin_6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration .
8265646	0	Interleukin_6	0,13	placental_lactogen_II	29,50	Interleukin 6	placental lactogen II	16193(Tax:10090)	18776(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interleukin_6 inhibits mouse placental_lactogen_II but not mouse placental_lactogen_I secretion in vitro .
22711534	0	Interleukin_6	0,13	promyelocytic_leukemia_protein	34,64	Interleukin 6	promyelocytic leukemia protein	3569	5371	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling regulates|dobj|expression expression|compound|END_ENTITY	Interleukin_6 signaling regulates promyelocytic_leukemia_protein gene expression in human normal and cancer cells .
25356114	0	Interleukin_6	0,13	sirtuin_1	69,78	Interleukin 6	sirtuin 1	24498(Tax:10116)	309757(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Interleukin_6 increases dysfunction of organs in sepsis rats through sirtuin_1 .
2166509	0	Interleukin_6	0,13	tissue_inhibitor_of_metalloproteinases	41,79	Interleukin 6	tissue inhibitor of metalloproteinases	3569	7076	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Interleukin_6 enhances the production of tissue_inhibitor_of_metalloproteinases -LRB- TIMP -RRB- but not that of matrix metalloproteinases by human fibroblasts .
8557680	0	Interleukin_6	0,13	vascular_endothelial_growth_factor	40,74	Interleukin 6	vascular endothelial growth factor	3569	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin_6 induces the expression of vascular_endothelial_growth_factor .
19136960	0	Interleukin_7	0,13	CD4	101,104	Interleukin 7	CD4	3574	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Interleukin_7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4 + T cells .
9918799	0	Interleukin_8	0,13	B1_receptor	53,64	Interleukin 8	B1 receptor	3576	623	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- induces the expression of kinin B1_receptor in human lung fibroblasts .
1383379	0	Interleukin_8	0,13	IL-4	81,85	Interleukin 8	IL-4	3576	3565	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|acl|induced induced|nmod|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- selectively inhibits immunoglobulin_E production induced by IL-4 in human B cells .
7864891	0	Interleukin_8	0,13	IL-4	49,53	Interleukin 8	IL-4	3576	3565	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
1383379	0	Interleukin_8	0,13	immunoglobulin_E	42,58	Interleukin 8	immunoglobulin E	3576	3497	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- selectively inhibits immunoglobulin_E production induced by IL-4 in human B cells .
7864891	0	Interleukin_8	0,13	interleukin_4	34,47	Interleukin 8	interleukin 4	3576	3565	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|IL-4 IL-4|nummod|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
20842712	0	Intersectin_1	34,47	GEF	18,21	Intersectin 1	GEF	6453	5923	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Autoinhibition of GEF activity in Intersectin_1 is mediated by the short SH3-DH domain linker .
26247961	0	Intestinal_Alkaline_Phosphatase	97,128	IAP	130,133	Intestinal Alkaline Phosphatase	IAP	11648(Tax:10090)	11648(Tax:10090)	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	Partial Enteral Nutrition Preserves Elements of Gut Barrier Function , Including Innate Immunity , Intestinal_Alkaline_Phosphatase -LRB- IAP -RRB- Level , and Intestinal Microbiota in Mice .
26247961	0	Intestinal_Alkaline_Phosphatase	97,128	IAP	130,133	Intestinal Alkaline Phosphatase	IAP	11648(Tax:10090)	11648(Tax:10090)	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	Partial Enteral Nutrition Preserves Elements of Gut Barrier Function , Including Innate Immunity , Intestinal_Alkaline_Phosphatase -LRB- IAP -RRB- Level , and Intestinal Microbiota in Mice .
18326859	0	Intestinal_trefoil_factor	0,25	TFF3	26,30	Intestinal trefoil factor	TFF3	21786(Tax:10090)	21786(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Intestinal_trefoil_factor / TFF3 promotes re-epithelialization of corneal wounds .
11564806	0	Intestinal_trefoil_factor	0,25	decay-accelerating_factor	34,59	Intestinal trefoil factor	decay-accelerating factor	7033	1604	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Intestinal_trefoil_factor induces decay-accelerating_factor expression and enhances the protective activities against complement activation in intestinal epithelial cells .
16648852	0	Ipaf	29,33	caspase-1	52,61	Ipaf	caspase-1	58484	834	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin_1beta in salmonella-infected macrophages .
17696608	0	Ipaf	79,83	caspase-1	27,36	Ipaf	caspase-1	58484	834	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activation activation|amod|END_ENTITY	Differential regulation of caspase-1 activation , pyroptosis , and autophagy via Ipaf and ASC in Shigella-infected macrophages .
16817903	0	Ipaf	43,47	caspase_1	15,24	Ipaf	caspase 1	58484	834	Gene	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of caspase_1 and its activator Ipaf upstream of mitochondrial events in apoptosis .
15196924	0	Ipaf	0,4	tumor_necrosis_factor-alpha	23,50	Ipaf	tumor necrosis factor-alpha	58484	7124	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Ipaf is upregulated by tumor_necrosis_factor-alpha in human leukemia cells .
7490099	0	Ipf1	47,51	insulin_promoter_factor_1	15,40	Ipf1	insulin promoter factor 1	18609(Tax:10090)	18609(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the insulin_promoter_factor_1 gene -LRB- Ipf1 -RRB- to distal mouse chromosome 5 .
20363740	0	IpgB2	22,27	RhoA	50,54	IpgB2	RhoA	13917053	387	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Structure of Shigella IpgB2 in complex with human RhoA : implications for the mechanism of bacterial guanine_nucleotide exchange factor mimicry .
9153231	0	Ipl1	142,146	Aik	95,98	Ipl1	Aik	855892(Tax:4932)	6790	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase , Aik , related to Aurora of Drosophila and yeast Ipl1 .
15796781	0	Iporin	39,45	rab1	81,85	Iporin	rab1	9853	5861	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of Iporin as a novel interaction partner for rab1 .
16793550	0	Ira1	115,119	Gpb1	19,23	Ira1	Gpb1	852437(Tax:4932)	854553(Tax:4932)	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2 .
20160012	0	Ira2	20,24	Gpb1	71,75	Ira2	Gpb1	854073(Tax:4932)	854553(Tax:4932)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans .
15075275	0	Ira2p	49,54	Tfs1p	0,5	Ira2p	Tfs1p	854073(Tax:4932)	850875(Tax:4932)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Tfs1p , a member of the PEBP family , inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces_cerevisiae .
15520230	0	Ire1	83,87	BiP	11,14	Ire1	BiP	2081	3309	Gene	Gene	stress-sensing|dobj|START_ENTITY stress-sensing|nsubj|role role|nmod|END_ENTITY	A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1 .
25692299	0	Ire1	45,49	BiP	24,27	Ire1	BiP	2081	2662	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling .
26692521	0	Irf6	0,4	Klf17	24,29	Irf6	Klf17	393570(Tax:7955)	65238(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium , and dominant-negative KLF4 variants are present in patients with cleft_lip_and_palate .
26693220	0	Irisin	43,49	PPAR-a	0,6	Irisin	PPAR-a	252995	5465	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
21566147	0	Iron_regulatory_protein_1	0,25	iron_regulatory_protein_2	38,63	Iron regulatory protein 1	iron regulatory protein 2	11428(Tax:10090)	64602(Tax:10090)	Gene	Gene	outcompetes|nsubj|START_ENTITY outcompetes|dobj|END_ENTITY	Iron_regulatory_protein_1 outcompetes iron_regulatory_protein_2 in regulating cellular iron homeostasis in response to nitric_oxide .
24814716	0	Irxl1	34,39	MyoD	61,65	Irxl1	MyoD	210719(Tax:10090)	17927(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The homeobox transcription factor Irxl1 negatively regulates MyoD expression and myoblast differentiation .
11208532	0	IsK	52,55	KvLQT1	27,33	IsK	KvLQT1	16509(Tax:10090)	16535(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Differential expression of KvLQT1 and its regulator IsK in mouse epithelia .
11414731	0	IsK	58,61	KvLQT1	23,29	IsK	KvLQT1	16509(Tax:10090)	16535(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Mice disrupted for the KvLQT1 potassium channel regulator IsK gene accumulate mature T cells .
8204631	0	IsK	96,99	minK	101,105	IsK	minK	398417(Tax:8355)	398417(Tax:8355)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Secondary structure and membrane localization of synthetic segments and a truncated form of the IsK -LRB- minK -RRB- protein .
9609707	0	IsK	116,119	minK	121,125	IsK	minK	3753	3753	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Conformation and ion-channeling activity of a 27-residue peptide modeled on the single-transmembrane segment of the IsK -LRB- minK -RRB- protein .
17603005	0	IscU	69,73	Nfs1	39,43	IscU	Nfs1	66383(Tax:10090)	18041(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the cysteine desulfurase Nfs1 and the scaffold protein IscU in macrophages stimulated with interferon-gamma and lipopolysaccharide .
12810567	0	Isg15	31,36	Interferon-stimulated_gene-15	0,29	Isg15	Interferon-stimulated gene-15	100038882(Tax:10090)	100038882(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interferon-stimulated_gene-15 -LRB- Isg15 -RRB- expression is up-regulated in the mouse uterus in response to the implanting conceptus .
10728423	0	Isk	79,82	KvLQT1	19,25	Isk	KvLQT1	3753	3784	Gene	Gene	interactions|nmod|START_ENTITY affect|nmod|interactions END_ENTITY|acl:relcl|affect	Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk .
11502362	0	Isl-1	87,92	Nerve_growth_factor	0,19	Isl-1	Nerve growth factor	64444(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Nerve_growth_factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion .
16613990	0	Isl-1	29,34	steroidogenic_factor_1	53,75	Isl-1	steroidogenic factor 1	3670	2516	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic_factor_1 to enhance gonadotrope-specific activity of the gonadotropin-releasing_hormone_receptor gene promoter .
21388963	0	Islet-1	0,7	Arx	18,21	Islet-1	Arx	3670	170302	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development .
24751901	0	Islet-1	65,72	ISL1	59,63	Islet-1	ISL1	3670	3670	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the LIM homeobox domain transcription factor ISL1 -LRB- Islet-1 -RRB- is frequent in rhabdomyosarcoma but very limited in other soft tissue sarcoma types .
26495868	0	Islet-1	21,28	SSBP3	0,5	Islet-1	SSBP3	16392(Tax:10090)	72475(Tax:10090)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic b-Cell Target Genes .
24469454	0	Isocitrate_Dehydrogenase	49,73	IDH	75,78	Isocitrate Dehydrogenase	IDH	3417	3417	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of ten-eleven_translocation_1 -LRB- TET1 -RRB- , Isocitrate_Dehydrogenase -LRB- IDH -RRB- expression , a-Ketoglutarate -LRB- a-KG -RRB- , and DNA hydroxymethylation levels by interleukin-1b in primary human chondrocytes .
26245674	0	Isocitrate_Dehydrogenase	73,97	IDH	99,102	Isocitrate Dehydrogenase	IDH	3417	3417	Gene	Gene	Mutant|compound|START_ENTITY Mutant|compound|END_ENTITY	Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate_Dehydrogenase -LRB- IDH -RRB- Mutant and IDH Wild-Type_Intrahepatic_Cholangiocarcinoma .
26245674	0	Isocitrate_Dehydrogenase	73,97	IDH	99,102	Isocitrate Dehydrogenase	IDH	3417	3417	Gene	Gene	Mutant|compound|START_ENTITY Mutant|compound|END_ENTITY	Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate_Dehydrogenase -LRB- IDH -RRB- Mutant and IDH Wild-Type_Intrahepatic_Cholangiocarcinoma .
24760710	0	Isocitrate_dehydrogenase_1	0,26	IDH1	28,32	Isocitrate dehydrogenase 1	IDH1	3417	3417	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Isocitrate_dehydrogenase_1 -LRB- IDH1 -RRB- mutation in breast_adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate .
20719964	0	Ist1	69,73	spartin	14,21	Ist1	spartin	9798	23111	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis .
18278048	0	Itch	24,28	Foxp3	74,79	Itch	Foxp3	16396(Tax:10090)	20371(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 .
20108139	0	Itch	86,90	Foxp3	0,5	Itch	Foxp3	83737	50943	Gene	Gene	regulation|nmod|START_ENTITY cells|dep|regulation cells|amod|END_ENTITY	Foxp3 positive regulatory T cells : a functional regulation by the E3 ubiquitin ligase Itch .
26694745	0	Itch	34,38	Itch	74,78	Itch	Itch	83737	83737	Gene	Gene	START_ENTITY|nmod|Patients Patients|nmod|END_ENTITY	Psychophysiological Processing of Itch in Patients with Chronic Post-burn Itch : An Exploratory Study .
26694745	0	Itch	74,78	Itch	34,38	Itch	Itch	83737	83737	Gene	Gene	Patients|nmod|START_ENTITY END_ENTITY|nmod|Patients	Psychophysiological Processing of Itch in Patients with Chronic Post-burn Itch : An Exploratory Study .
21093410	0	Itch	78,82	MDM2	0,4	Itch	MDM2	83737	4193	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|nsubj|END_ENTITY	MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells .
19710465	0	Itch	27,31	MEKK1	0,5	Itch	MEKK1	83737	4214	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression .
25632008	0	Itch	17,21	Ndfip1	0,6	Itch	Ndfip1	16396(Tax:10090)	65113(Tax:10090)	Gene	Gene	Activity|compound|START_ENTITY Regulates|dobj|Activity Regulates|nsubj|END_ENTITY	Ndfip1 Regulates Itch Ligase Activity and Airway Inflammation via UbcH7 .
20818436	0	Itch	29,33	Numb	0,4	Itch	Numb	83737	8650	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal .
25518932	0	Itch	0,4	TGF-b	46,51	Itch	TGF-b	83737	7040	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	Itch E3 Ubiquitin Ligase Positively Regulates TGF-b Signaling to EMT via Smad7 Ubiquitination .
15678106	0	Itch	29,33	p73	44,47	Itch	p73	83737	7161	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	The ubiquitin-protein ligase Itch regulates p73 stability .
20491914	0	Itch	24,28	sorting_nexin_9	39,54	Itch	sorting nexin 9	83737	51429	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The E3 ubiquitin ligase Itch regulates sorting_nexin_9 through an unconventional substrate recognition domain .
20884890	0	ItgaL	78,83	VEGF	0,4	ItgaL	VEGF	3683	7422	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	VEGF differentially regulates neutrophil and T cell adhesion through ItgaL - and ItgaM-dependent mechanisms .
24130503	0	Itgal	47,52	integrin_alpha_L	29,45	Itgal	integrin alpha L	16408(Tax:10090)	16408(Tax:10090)	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Natural genetic variation of integrin_alpha_L -LRB- Itgal -RRB- modulates ischemic_brain_injury in stroke .
23789592	0	Itgb1	66,71	integrin_b1	53,64	Itgb1	integrin b1	16412(Tax:10090)	16412(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The use of alternative polyadenylation sites renders integrin_b1 -LRB- Itgb1 -RRB- mRNA isoforms with differential stability during mammary gland development .
15814667	0	Itk	0,3	CD28	25,29	Itk	CD28	16428(Tax:10090)	12487(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Itk is not essential for CD28 signaling in naive T cells .
16424186	0	Itk	12,15	CD4	111,114	Itk	CD4	16428(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|xcomp|virus_infection virus_infection|nmod|help help|compound|END_ENTITY	Tec kinases Itk and Rlk are required for CD8 + T cell responses to virus_infection independent of their role in CD4 + T cell help .
18453573	0	Itk	86,89	CD4	34,37	Itk	CD4	16428(Tax:10090)	12504(Tax:10090)	Gene	Gene	requirements|nmod|START_ENTITY have|dobj|requirements have|nsubj|cells cells|compound|END_ENTITY	Naive and innate memory phenotype CD4 + T cells have different requirements for active Itk for their development .
19443662	0	Itk	66,69	CD4	24,27	Itk	CD4	16428(Tax:10090)	12504(Tax:10090)	Gene	Gene	results|compound|START_ENTITY absence|nmod|results +|nmod|absence +|nsubj|development development|nmod|END_ENTITY	Enhanced development of CD4 + gammadelta T cells in the absence of Itk results in elevated IgE production .
25568116	0	Itk	0,3	CD4	52,55	Itk	CD4	16428(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Itk Signals Promote Neuroinflammation by Regulating CD4 + T-Cell Activation and Trafficking .
17579028	0	Itk	15,18	IFN_gamma	27,36	Itk	IFN gamma	16428(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|production production|compound|END_ENTITY	A key role for Itk in both IFN_gamma and IL-4 production by NKT cells .
21158938	0	Itk	50,53	IL-2-inducible_tyrosine_kinase	18,48	Itk	IL-2-inducible tyrosine kinase	16428(Tax:10090)	16428(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Inhibition of the IL-2-inducible_tyrosine_kinase -LRB- Itk -RRB- activity : a new concept for the therapy of inflammatory skin_diseases .
15661896	0	Itk	33,36	Vav	66,69	Itk	Vav	3702	7409	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton .
11830645	0	Itk	34,37	cyclophilin_A	71,84	Itk	cyclophilin A	3702	5478	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin_A .
9130632	0	Itk	0,3	interleukin-2	69,82	Itk	interleukin-2	3702	3558	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Itk , a T cell-specific tyrosine kinase , is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat .
25590759	0	Iws1	49,53	LEDGF/p75	23,32	Iws1	LEDGF/p75	55677	11168	Gene	Gene	Associates|nmod|START_ENTITY Associates|compound|END_ENTITY	The Integrase Cofactor LEDGF/p75 Associates with Iws1 and Spt6 for Postintegration Silencing of HIV-1 Gene Expression in Latently Infected Cells .
20345897	0	Ixr1p	0,5	HEM13	33,38	Ixr1p	HEM13	853836(Tax:4932)	851614(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Ixr1p regulates oxygen-dependent HEM13 transcription .
25209248	0	Izumo1	25,31	Juno	53,57	Izumo1	Juno	284359	390243	Gene	Gene	Binding|nmod|START_ENTITY drives|dep|Binding drives|nsubj|END_ENTITY	Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization .
25533103	0	Izumo1	91,97	Juno	55,59	Izumo1	Juno	284359	390243	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Cross-species fertilization : the hamster egg receptor , Juno , binds the human sperm ligand , Izumo1 .
9883901	0	JAB	64,67	JAK2	42,46	JAB	JAK2	8651	3717	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Cytokine-inducible_SH2_protein -LRB- CIS3 -RRB- and JAK2 binding protein -LRB- JAB -RRB- abolish prolactin_receptor-mediated STAT5 signaling .
9789053	0	JAB	39,42	SOCS-1	32,38	JAB	SOCS-1	8651	8651	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Three distinct domains of SSI-1 / SOCS-1 / JAB protein are required for its suppression of interleukin_6 signaling .
9789053	0	JAB	39,42	SSI-1	26,31	JAB	SSI-1	8651	8651	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Three distinct domains of SSI-1 / SOCS-1 / JAB protein are required for its suppression of interleukin_6 signaling .
10766246	0	JAB1	63,67	LFA-1	9,14	JAB1	LFA-1	10987	3689	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity .
23911788	0	JAB1	0,4	STAT3	32,37	JAB1	STAT3	10987	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon_cancer cells .
15930262	0	JAB1	67,71	p27	33,36	JAB1	p27	10987	3429	Gene	Gene	stability|nmod|START_ENTITY stability|amod|END_ENTITY	Tumor suppressor VDUP1 increases p27 -LRB- kip1 -RRB- stability by inhibiting JAB1 .
20698225	0	JAB1	0,4	p27	57,60	JAB1	p27	10987	3429	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|nmod|kip1 kip1|amod|END_ENTITY	JAB1 expression is associated with inverse expression of p27 -LRB- kip1 -RRB- in hepatocellular_carcinoma .
10722692	0	JAB1	0,4	progesterone_receptor	29,50	JAB1	progesterone receptor	10987	5241	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	JAB1 interacts with both the progesterone_receptor and SRC-1 .
11698665	0	JAC	0,3	Jun	55,58	JAC	Jun	425968(Tax:9031)	3725	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	JAC , a direct target of oncogenic transcription factor Jun , is involved in cell transformation and tumorigenesis .
12836255	0	JAGGED1	30,37	HOXD3	0,5	JAGGED1	HOXD3	182	3232	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HOXD3 regulates expression of JAGGED1 , a ligand for Notch receptors .
22822207	0	JAGGED_LATERAL_ORGANS	12,33	ASYMMETRIC_LEAVES2	44,62	JAGGED LATERAL ORGANS	ASYMMETRIC LEAVES2	828084(Tax:3702)	842873(Tax:3702)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Arabidopsis JAGGED_LATERAL_ORGANS acts with ASYMMETRIC_LEAVES2 to coordinate KNOX and PIN expression in shoot and root meristems .
7796812	0	JAK	41,44	Janus_kinase	27,39	JAK	Janus kinase	32080(Tax:7227)	32080(Tax:7227)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of a Drosophila Janus_kinase -LRB- JAK -RRB- causes hematopoietic_neoplasia and developmental defects .
17090651	0	JAK-2	151,156	STAT-5	157,163	JAK-2	STAT-5	3717	6776	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Adaptive secretion of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- mediates imatinib and nilotinib resistance in BCR/ABL + progenitors via JAK-2 / STAT-5 pathway activation .
23214979	0	JAK1	72,76	JAK3	64,68	JAK1	JAK3	3716	3718	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	3-Amido_pyrrolopyrazine JAK kinase inhibitors : development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models .
21551237	0	JAK1	37,41	PTPN2	0,5	JAK1	PTPN2	3716	5771	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PTPN2 negatively regulates oncogenic JAK1 in T-cell_acute_lymphoblastic_leukemia .
23296072	0	JAK1	38,42	SHP-1	32,37	JAK1	SHP-1	3716	5777	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Structure-guided studies of the SHP-1 / JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition .
20974963	0	JAK1	72,76	STAT5	38,43	JAK1	STAT5	3716	6776	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Thymic_stromal_lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling .
9815665	0	JAK1	47,51	bcr-abl	18,25	JAK1	bcr-abl	3716	25	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Potential role of bcr-abl in the activation of JAK1 kinase .
7525556	0	JAK1	41,45	growth_hormone	66,80	JAK1	growth hormone	3716	2688	Gene	Gene	phosphorylation|nmod|START_ENTITY tyrosine|dobj|phosphorylation tyrosine|nmod|END_ENTITY	Differential tyrosine phosphorylation of JAK1 , JAK2 , and STAT1 by growth_hormone and interferon-gamma in IM-9 cells .
7537214	0	JAK1	45,49	interleukin-6	109,122	Tyk2	interleukin-6	7297	3569	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nmod|END_ENTITY	A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6 .
24325359	0	JAK2	71,75	CALR	8,12	JAK2	CALR	3717	811	Gene	Gene	mutations|nmod|START_ENTITY mutations|nsubj|END_ENTITY	Somatic CALR mutations in myeloproliferative_neoplasms with nonmutated JAK2 .
22489043	0	JAK2	53,57	CBL	28,31	JAK2	CBL	3717	867	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
23696637	0	JAK2	152,156	CBL	0,3	KRAS	CBL	3845	867	Gene	Gene	levels|nmod|START_ENTITY signaling|nmod|levels granulocyte-macrophage_colony-stimulating_factor|acl|signaling lead|nmod|granulocyte-macrophage_colony-stimulating_factor lead|nsubj|region region|compound|END_ENTITY	CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- signaling via elevated levels of JAK2 and LYN .
10676635	0	JAK2	71,75	CD30	79,83	JAK2	CD30	3717	943	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30 + Hodgkin cells .
22489043	0	JAK2	53,57	DNMT3A	33,39	JAK2	DNMT3A	3717	1788	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
11881154	0	JAK2	112,116	EGF_receptor	79,91	JAK2	EGF receptor	3717	1956	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- H2O2-induced activation of transcription factors STAT1 and STAT3 : the role of EGF_receptor and tyrosine kinase JAK2 -RSB- .
25869210	0	JAK2	0,4	EGF_receptor	107,119	JAK2	EGF receptor	3717	1956	Gene	Gene	TG101348|compound|START_ENTITY overcomes|nsubj|TG101348 overcomes|xcomp|erlotinib-resistance erlotinib-resistance|nmod|cells cells|nmod|END_ENTITY	JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small_cell_lung_carcinoma cells with mutated EGF_receptor .
16290054	0	JAK2	27,31	Endothelin-1	0,12	JAK2	Endothelin-1	24514(Tax:10116)	24323(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD -LRB- P -RRB- H oxidase-derived reactive oxygen species .
21620963	0	JAK2	144,148	Erythropoietin	0,14	JAK2	Erythropoietin	3717	2056	Gene	Gene	PI3K|compound|START_ENTITY role|nmod|PI3K cells|dep|role protects|dobj|cells protects|nsubj|END_ENTITY	Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions : essential role of JAK2 / PI3K signaling .
24004818	0	JAK2	20,24	Erythropoietin	0,14	JAK2	Erythropoietin	3717	2056	Gene	Gene	effector|compound|START_ENTITY effector|nsubj|END_ENTITY	Erythropoietin is a JAK2 and ERK1/2 effector that can promote renal_tumor cell proliferation under hypoxic conditions .
8068943	0	JAK2	42,46	Erythropoietin	0,14	JAK2	Erythropoietin	3717	2056	Gene	Gene	kinase|compound|START_ENTITY association|nmod|kinase induces|dobj|association induces|nsubj|END_ENTITY	Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo .
19884384	0	JAK2	131,135	GHR	91,94	JAK2	GHR	16452(Tax:10090)	14600(Tax:10090)	Gene	Gene	signal|nmod|START_ENTITY signal|nsubj|END_ENTITY	In vivo targeting of the growth_hormone_receptor -LRB- GHR -RRB- Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2 .
8631962	0	JAK2	60,64	Granulocyte-macrophage_colony-stimulating_factor	0,48	JAK2	Granulocyte-macrophage colony-stimulating factor	3717	1437	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor stimulates JAK2 signaling pathway and rapidly activates p93fes , STAT1 p91 , and STAT3_p92 in polymorphonuclear leukocytes .
8770909	0	JAK2	54,58	Growth_hormone	0,14	JAK2	Growth hormone	24514(Tax:10116)	81668(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates tyrosine phosphorylation of JAK2 and STAT5 , but not insulin_receptor_substrate-1 or SHC proteins in liver and skeletal muscle of normal rats in vivo .
9553131	0	JAK2	112,116	Growth_hormone	0,14	JAK2	Growth hormone	16452(Tax:10090)	14599(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
9886807	0	JAK2	58,62	Growth_hormone	0,14	JAK2	Growth hormone	24514(Tax:10116)	81668(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin_receptor substrates and Shc in rat tissues .
22489043	0	JAK2	53,57	IDH1	41,45	JAK2	IDH1	3717	3417	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	JAK2	53,57	IDH2	47,51	JAK2	IDH2	3717	3418	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
7499845	0	JAK2	55,59	IFN-gamma	127,136	JAK2	IFN-gamma	16452(Tax:10090)	15978(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
7499845	0	JAK2	55,59	IFN-gamma	18,27	JAK2	IFN-gamma	16452(Tax:10090)	15978(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|sites sites|amod|END_ENTITY	Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma -LRB- 95-133 -RRB- .
7528775	0	JAK2	59,63	IL-2	127,131	JAK2	IL-2	3717	3558	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nmod|END_ENTITY	Interleukin 12 -LRB- IL-12 -RRB- induces tyrosine phosphorylation of JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 .
8630039	0	JAK2	33,37	Interleukin_3	0,13	JAK2	Interleukin 3	16452(Tax:10090)	16187(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Interleukin_3 activates not only JAK2 and STAT5 , but also Tyk2 , STAT1 , and STAT3 .
9883901	0	JAK2	42,46	JAB	64,67	JAK2	JAB	3717	8651	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Cytokine-inducible_SH2_protein -LRB- CIS3 -RRB- and JAK2 binding protein -LRB- JAB -RRB- abolish prolactin_receptor-mediated STAT5 signaling .
22622019	0	JAK2	40,44	Janus-activated_kinase-2	14,38	JAK2	Janus-activated kinase-2	3717	3717	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Janus-activated_kinase-2 -LRB- JAK2 -RRB- by diindolylmethane in ovarian_cancer in vitro and in vivo .
17133423	0	JAK2	33,37	Janus_kinase_2	17,31	JAK2	Janus kinase 2	3717	3717	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Clearance of the Janus_kinase_2 -LRB- JAK2 -RRB- V617F mutation after allogeneic stem cell transplantation in a patient with myelofibrosis with myeloid_metaplasia .
19215672	0	JAK2	39,43	Janus_kinase_2	23,37	JAK2	Janus kinase 2	3717	3717	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Quantitative assay for Janus_kinase_2 -LRB- JAK2 -RRB- mutation in Chinese patients with chronic_myeloproliferative_disorders .
20359349	0	JAK2	81,85	Janus_kinase_2	65,79	JAK2	Janus kinase 2	3717	3717	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Quantitative assay for the detection of the V617F variant in the Janus_kinase_2 -LRB- JAK2 -RRB- gene using the Luminex xMAP technology .
21477644	0	JAK2	28,32	Janus_kinase_2	12,26	JAK2	Janus kinase 2	3717	3717	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	The role of Janus_kinase_2 -LRB- JAK2 -RRB- activation in pneumococcal EstA protein-induced inflammatory response in RAW 264.7 macrophages .
18479730	0	JAK2	130,134	MPL	42,45	JAK2	MPL	3717	4352	Gene	Gene	V617F|compound|START_ENTITY chronic_myeloproliferative_disorders|nmod|V617F seen|nmod|chronic_myeloproliferative_disorders that|acl|seen similar|nmod|that similar|nsubj|pattern pattern|nmod|mutation mutation|compound|END_ENTITY	Phospho-STAT5 expression pattern with the MPL W515L mutation is similar to that seen in chronic_myeloproliferative_disorders with JAK2 V617F .
21326037	0	JAK2	24,28	MPL	0,3	JAK2	MPL	3717	4352	Gene	Gene	patients|nummod|START_ENTITY mutation|nmod|patients mutation|nsubj|END_ENTITY	MPL mutation profile in JAK2 mutation-negative patients with myeloproliferative_disorders .
22489043	0	JAK2	53,57	MPL	59,62	JAK2	MPL	3717	4352	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22565617	0	JAK2	0,4	MPL	23,26	JAK2	MPL	3717	4352	Gene	Gene	GGCC|compound|START_ENTITY haplotype|nsubj|GGCC haplotype|nmod|myeloproliferative_neoplasms myeloproliferative_neoplasms|compound|END_ENTITY	JAK2 GGCC haplotype in MPL mutated myeloproliferative_neoplasms .
22596167	0	JAK2	0,4	MPL	26,29	JAK2	MPL	3717	4352	Gene	Gene	V617F|compound|START_ENTITY down-modulates|nsubj|V617F down-modulates|dobj|END_ENTITY	JAK2 V617F down-modulates MPL .
25781882	0	JAK2	94,98	Mcl-1	17,22	JAK2	Mcl-1	3717	4170	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	JAK2V617F Drives Mcl-1 Expression and Sensitizes Hematologic Cell Lines to Dual Inhibition of JAK2 and Bcl-xL .
20548334	0	JAK2	92,96	MiR-375	0,7	JAK2	MiR-375	3717	494324	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-375 frequently downregulated in gastric_cancer inhibits cell proliferation by targeting JAK2 .
25055044	0	JAK2	93,97	MiR-375	16,23	JAK2	MiR-375	3717	494324	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Snail-regulated MiR-375 inhibits migration and invasion of gastric_cancer cells by targeting JAK2 .
7556623	0	JAK2	78,82	NF-kappa_B	24,34	JAK2	NF-kappa B	3717	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Herbimycin_A suppresses NF-kappa_B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric_oxide synthase in C6 glioma cells .
22489043	0	JAK2	53,57	NF1	64,67	JAK2	NF1	3717	4763	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
8876196	0	JAK2	39,43	Raf-1	54,59	JAK2	Raf-1	3717	5894	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner .
22489043	0	JAK2	53,57	SF3B1	69,74	JAK2	SF3B1	3717	23451	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
15970430	0	JAK2	53,57	STAT3	82,87	JAK2	STAT3	3717	6774	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2 .
16517948	0	JAK2	71,75	STAT3	93,98	JAK2	STAT3	24514(Tax:10116)	25125(Tax:10116)	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	The JAK/STAT pathway is essential for opioid-induced_cardioprotection : JAK2 as a mediator of STAT3 , Akt , and GSK-3_beta .
19063868	0	JAK2	134,138	STAT3	153,158	JAK2	STAT3	24514(Tax:10116)	25125(Tax:10116)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation : central role for JAK2 activation of STAT3 and NF-kappaB .
21993263	0	JAK2	19,23	STAT3	71,76	JAK2	STAT3	3717	6774	Gene	Gene	receptor|amod|START_ENTITY Phosphorylation|nmod|receptor activates|nsubj|Phosphorylation activates|dobj|pathways pathways|compound|END_ENTITY	Phosphorylation of JAK2 by serotonin_5-HT _ -LRB- 2A -RRB- _ receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental_choriocarcinoma cell .
22319590	0	JAK2	22,26	STAT3	0,5	JAK2	STAT3	3717	6774	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small_cell_lung_carcinoma .
24890449	0	JAK2	108,112	STAT3	90,95	JAK2	STAT3	3717	6774	Gene	Gene	phosphorylation|amod|START_ENTITY blocking|dobj|phosphorylation induces|advcl|blocking induces|nmod|inactivation inactivation|nmod|END_ENTITY	Thymoquinone induces apoptosis in human colon_cancer HCT116 cells through inactivation of STAT3 by blocking JAK2 - and Src - mediated phosphorylation of EGF receptor tyrosine kinase .
25107644	0	JAK2	55,59	STAT3	87,92	JAK2	STAT3	3717	6774	Gene	Gene	inhibitors|nummod|START_ENTITY class|nmod|inhibitors analogues|appos|class N|dep|analogues N|dep|END_ENTITY	N -LRB- 6 -RRB- - Substituted adenosine analogues , a novel class of JAK2 inhibitors , potently block STAT3 signaling in human cancer cells .
25619393	0	JAK2	51,55	STAT3	19,24	JAK2	STAT3	3717	6774	Gene	Gene	inactivating|dobj|START_ENTITY signaling|advcl|inactivating END_ENTITY|acl|signaling	Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells .
26343046	0	JAK2	105,109	STAT3	128,133	JAK2	STAT3	16452(Tax:10090)	20848(Tax:10090)	Gene	Gene	kinase|appos|START_ENTITY kinase|dep|transcription transcription|dobj|3 3|appos|END_ENTITY	Protective effect of Fenofibrate in renal_ischemia reperfusion injury : Involved in suppressing kinase 2 -LRB- JAK2 -RRB- / transcription 3 -LRB- STAT3 -RRB- / p53 signaling activation .
26936086	0	JAK2	93,97	STAT3	100,105	JAK2	STAT3	3717	6774	Gene	Gene	osteoarthritis|nmod|START_ENTITY model|nmod|osteoarthritis chondrocytes|nmod|model apoptosis|nmod|chondrocytes apoptosis|dep|END_ENTITY	Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2 - STAT3 signaling pathway .
10585851	0	JAK2	130,134	STAT5	188,193	JAK2	STAT5	24514(Tax:10116)	24918(Tax:10116)	Gene	Gene	janus_kinase_2|appos|START_ENTITY janus_kinase_2|dep|signal_transducer_and_activator_of_transcription_5 signal_transducer_and_activator_of_transcription_5|appos|END_ENTITY	Stimulation of pancreatic beta-cell proliferation by growth_hormone is glucose-dependent : signal transduction via janus_kinase_2 -LRB- JAK2 -RRB- / signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- with no crosstalk to insulin receptor substrate-mediated mitogenic signalling .
12107179	0	JAK2	139,143	STAT5	197,202	JAK2	STAT5	24514(Tax:10116)	24918(Tax:10116)	Gene	Gene	transducers|appos|START_ENTITY transducers|nmod|system system|appos|END_ENTITY	1Alpha,25-dihydroxyvitamin _ D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus_kinase -LRB- JAK2 -RRB- / signal transducers and activators of transcription -LRB- STAT5 -RRB- system in osteoblast-like cells .
15671147	0	JAK2	118,122	STAT5	65,70	JAK2	STAT5	3717	6776	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Stem_cell_factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase .
20028972	0	JAK2	103,107	STAT5	0,5	JAK2	STAT5	16452(Tax:10090)	20850(Tax:10090)	Gene	Gene	mutant|compound|START_ENTITY mediated|nmod|mutant transformation|acl|mediated critical|nmod|transformation critical|nsubj|activation activation|compound|END_ENTITY	STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant .
22382519	0	JAK2	115,119	STAT5	173,178	JAK2	STAT5	3717	6776	Gene	Gene	Janus_kinase-2|appos|START_ENTITY Janus_kinase-2|dep|signalling signalling|dep|transducer transducer|nmod|transcription-5 transcription-5|appos|END_ENTITY	Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus_kinase-2 -LRB- JAK2 -RRB- / signal transducer and activator of transcription-5 -LRB- STAT5 -RRB- signalling .
17652621	0	JAK2	97,101	STAT6	131,136	JAK2	STAT6	3717	6778	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin_lymphoma is accompanied by high JAK2 expression and activation of STAT6 .
19962667	0	JAK2	4,8	Stat3	43,48	JAK2	Stat3	3717	6774	Gene	Gene	AZD1480|compound|START_ENTITY blocks|nsubj|AZD1480 blocks|dobj|signaling signaling|amod|END_ENTITY	The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid_tumors .
21941370	0	JAK2	27,31	Stat5	63,68	JAK2	Stat5	16452(Tax:10090)	20850(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY elevates|nsubj|activation elevates|dobj|signalling signalling|amod|END_ENTITY	Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling , promotes alveologenesis and resistance to cell death , and contributes to tumourigenesis .
17229652	0	JAK2	29,33	Tyrosine_kinase	0,15	JAK2	Tyrosine kinase	3717	7294	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Tyrosine_kinase mutations of JAK2 are rare events in AML but influence prognosis of patients with CBF-leukemias .
21904853	0	JAK2	44,48	c-CBL	29,34	JAK2	c-CBL	3717	867	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	TET2 , ASXL1 , IDH1 , IDH2 , and c-CBL genes in JAK2 - and MPL-negative myeloproliferative_neoplasms .
8677747	0	JAK2	0,4	c-Kit	39,44	JAK2	c-Kit	3717	3815	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem_cell_factor .
23393003	0	JAK2	58,62	era	51,54	JAK2	era	3717	26284	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Diagnosis and therapy of polycythemia_vera in the era of JAK2 -RSB- .
16465216	0	JAK2	81,85	erythropoietin	50,64	JAK2	erythropoietin	3717	2056	Gene	Gene	involvement|nmod|START_ENTITY kinases|nsubj|involvement erythroid|parataxis|kinases erythroid|nmod|END_ENTITY	Prevention of apoptosis in J2E erythroid cells by erythropoietin : involvement of JAK2 but not MAP kinases .
16827884	0	JAK2	145,149	erythropoietin	15,29	JAK2	erythropoietin	3717	2056	Gene	Gene	analysis|compound|START_ENTITY role|nmod|analysis implications|nmod|role levels|dep|implications levels|compound|END_ENTITY	Elevated serum erythropoietin levels in patients with Budd-Chiari_syndrome secondary to polycythemia vera : clinical implications for the role of JAK2 mutation analysis .
17389763	0	JAK2	4,8	erythropoietin	34,48	JAK2	erythropoietin	3717	2056	Gene	Gene	mutation|compound|START_ENTITY triggers|nsubj|mutation triggers|dobj|hypersensitivity hypersensitivity|compound|END_ENTITY	The JAK2 617V > F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia_vera .
17719087	0	JAK2	115,119	erythropoietin	80,94	JAK2	erythropoietin	3717	2056	Gene	Gene	V617F-positive|compound|START_ENTITY show|nmod|V617F-positive show|nmod|END_ENTITY	Most pediatric patients with essential_thrombocythemia show hypersensitivity to erythropoietin in vitro , with rare JAK2 V617F-positive erythroid colonies .
18055983	0	JAK2	17,21	erythropoietin	93,107	JAK2	erythropoietin	3717	2056	Gene	Gene	frequency|nmod|START_ENTITY exon|nsubj|frequency exon|nmod|levels levels|compound|END_ENTITY	The frequency of JAK2 exon 12 mutations in idiopathic_erythrocytosis patients with low serum erythropoietin levels .
7889566	0	JAK2	86,90	erythropoietin	39,53	JAK2	erythropoietin	3717	2056	Gene	Gene	inactivation|nmod|START_ENTITY causes|dobj|inactivation causes|nsubj|recruitment recruitment|nmod|SH-PTP1 SH-PTP1|nmod|receptor receptor|compound|END_ENTITY	Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals .
8068943	0	JAK2	42,46	erythropoietin	80,94	JAK2	erythropoietin	3717	2056	Gene	Gene	kinase|compound|START_ENTITY association|nmod|kinase induces|dobj|association induces|nmod|receptor receptor|compound|END_ENTITY	Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo .
8343951	0	JAK2	0,4	erythropoietin	25,39	JAK2	erythropoietin	3717	2056	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin .
8943308	0	JAK2	15,19	erythropoietin	35,49	JAK2	erythropoietin	3717	2056	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|receptors receptors|compound|END_ENTITY	Association of JAK2 and STAT5 with erythropoietin receptors .
9052992	0	JAK2	61,65	erythropoietin	18,32	JAK2	erythropoietin	3717	2056	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells .
21255641	0	JAK2	141,145	erythropoietin_receptor	46,69	JAK2	erythropoietin receptor	16452(Tax:10090)	13857(Tax:10090)	Gene	Gene	transformation|compound|START_ENTITY required|nmod|transformation required|nsubjpass|Akt Akt|acl|activation activation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Akt activation through the phosphorylation of erythropoietin_receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation .
9553131	0	JAK2	112,116	focal_adhesion_kinase	79,100	JAK2	focal adhesion kinase	16452(Tax:10090)	14083(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
23696637	0	JAK2	152,156	granulocyte-macrophage_colony-stimulating_factor	61,109	KRAS	granulocyte-macrophage colony-stimulating factor	3845	1437	Gene	Gene	levels|nmod|START_ENTITY signaling|nmod|levels END_ENTITY|acl|signaling	CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- signaling via elevated levels of JAK2 and LYN .
8007942	0	JAK2	0,4	granulocyte-macrophage_colony-stimulating_factor	58,106	JAK2	granulocyte-macrophage colony-stimulating factor	3717	1437	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|chain chain|nmod|receptor receptor|nmod|END_ENTITY	JAK2 associates with the beta_c chain of the receptor for granulocyte-macrophage_colony-stimulating_factor , and its activation requires the membrane-proximal region .
8647882	0	JAK2	0,4	granulocyte-macrophage_colony-stimulating_factor	103,151	JAK2	granulocyte-macrophage colony-stimulating factor	3717	12981(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|receptor receptor|amod|END_ENTITY	JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage_colony-stimulating_factor receptor in BA/F3 cells .
9028317	0	JAK2	14,18	granulocyte-macrophage_colony-stimulating_factor	58,106	JAK2	granulocyte-macrophage colony-stimulating factor	3717	1437	Gene	Gene	Activation|nmod|START_ENTITY endothelial|nsubj|Activation endothelial|nmod|END_ENTITY	Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage_colony-stimulating_factor .
9680354	0	JAK2	135,139	granulocyte-macrophage_colony-stimulating_factor	42,90	JAK2	granulocyte-macrophage colony-stimulating factor	3717	1437	Gene	Gene	activation|nmod|START_ENTITY alpha|nmod|activation alpha|nsubj|Characterization Characterization|nmod|role role|nmod|receptor receptor|amod|END_ENTITY	Characterization of the role of the human granulocyte-macrophage_colony-stimulating_factor receptor alpha subunit in the activation of JAK2 and STAT5 .
10912517	0	JAK2	28,32	growth_hormone	59,73	JAK2	growth hormone	3717	2688	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Role of the tyrosine kinase JAK2 in signal transduction by growth_hormone .
8537333	0	JAK2	0,4	growth_hormone	124,138	JAK2	growth hormone	3717	2688	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	JAK2 , Ras , and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth_hormone .
25101218	0	JAK2	58,62	growth_hormone_receptor	20,43	JAK2	growth hormone receptor	3717	2690	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	A new mechanism for growth_hormone_receptor activation of JAK2 , and implications for related cytokine receptors .
16959246	0	JAK2	113,117	janus_kinase_2	97,111	JAK2	janus kinase 2	3717	3717	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chronic_idiopathic_myelofibrosis -LRB- CIMF -RRB- resulting from a unique 3 ; 9 translocation disrupting the janus_kinase_2 -LRB- JAK2 -RRB- gene .
7508935	0	JAK2	50,54	prolactin	58,67	JAK2	prolactin	24514(Tax:10116)	24683(Tax:10116)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Activation of receptor-associated tyrosine kinase JAK2 by prolactin .
7925093	0	JAK2	0,4	prolactin_receptor	68,86	JAK2	prolactin receptor	3717	5618	Gene	Gene	activation|nummod|START_ENTITY induced|nsubj|activation induced|nmod|dimerization dimerization|compound|END_ENTITY	JAK2 activation and cell proliferation induced by antibody-mediated prolactin_receptor dimerization .
9099911	0	JAK2	157,161	prolactin_receptor	82,100	JAK2	prolactin receptor	100358134(Tax:9986)	100009046(Tax:9986)	Gene	Gene	activation|compound|START_ENTITY obligatory|nmod|activation obligatory|nsubj|part part|nmod|END_ENTITY	Prolactin signal transduction to milk protein genes : carboxy-terminal part of the prolactin_receptor and its tyrosine phosphorylation are not obligatory for JAK2 and STAT5 activation .
9202403	0	JAK2	60,64	prolactin_receptor	98,116	JAK2	prolactin receptor	3717	5618	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin_receptor .
24948418	0	JAK2	37,41	protein_tyrosine_phosphatase_1B	73,104	JAK2	protein tyrosine phosphatase 1B	16452(Tax:10090)	19246(Tax:10090)	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Regulation of growth_hormone induced JAK2 and mTOR signalling by hepatic protein_tyrosine_phosphatase_1B .
23214979	0	JAK3	64,68	JAK1	72,76	JAK3	JAK1	3718	3716	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	3-Amido_pyrrolopyrazine JAK kinase inhibitors : development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models .
15368094	0	JAK3	16,20	Janus_kinase-3	0,14	JAK3	Janus kinase-3	3718	3718	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Janus_kinase-3 -LRB- JAK3 -RRB- inhibition : a novel immunosuppressive option for allogeneic transplantation .
25762693	0	JAK3	49,53	Janus_kinase_3	33,47	JAK3	Janus kinase 3	3718	3718	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	VX-509 is a potent and selective Janus_kinase_3 -LRB- JAK3 -RRB- inhibitor that attenuates inflammation in animal models of autoimmune_disease .
24762999	0	JAK3	65,69	SHP-1	58,63	JAK3	SHP-1	3718	5777	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	-LSB- Effect of arsenic_trioxide and 5-aza-2 ' - deoxycytidine on SHP-1 , JAK3 , TYK2 gene expression in K562 cells -RSB- .
24762999	0	JAK3	65,69	TYK2	71,75	JAK3	TYK2	3718	7297	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	-LSB- Effect of arsenic_trioxide and 5-aza-2 ' - deoxycytidine on SHP-1 , JAK3 , TYK2 gene expression in K562 cells -RSB- .
7538655	0	JAK3	0,4	interleukin_4_receptor	31,53	JAK3	interleukin 4 receptor	3718	3566	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	JAK3 associates with the human interleukin_4_receptor and is tyrosine phosphorylated following receptor triggering .
20709526	0	JAK3	155,159	vascular_endothelial_growth_factor	79,113	JAK3	vascular endothelial growth factor	3718	7422	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	STAT3 activation induced by Epstein-Barr_virus latent membrane protein1 causes vascular_endothelial_growth_factor expression and cellular invasiveness via JAK3 And ERK signaling .
12953056	0	JAM	34,37	JAM-2	54,59	JAM	JAM-2	50848	58494	Gene	Gene	members|appos|START_ENTITY members|amod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
12953056	0	JAM	34,37	junctional_adhesion_molecule	4,32	JAM	junctional adhesion molecule	50848	50848	Gene	Gene	members|appos|START_ENTITY members|amod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
11812992	0	JAM-1	0,5	LFA-1	42,47	JAM-1	LFA-1	50848	3683	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	JAM-1 is a ligand of the beta -LRB- 2 -RRB- integrin LFA-1 involved in transendothelial migration of leukocytes .
12953056	0	JAM-2	54,59	JAM	34,37	JAM-2	JAM	58494	50848	Gene	Gene	members|amod|START_ENTITY members|appos|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
12953056	0	JAM-2	54,59	PAR-3	111,116	JAM-2	PAR-3	58494	56288	Gene	Gene	members|amod|START_ENTITY associate|nsubj|members associate|nmod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
12953056	0	JAM-2	54,59	junctional_adhesion_molecule	4,32	JAM-2	junctional adhesion molecule	58494	50848	Gene	Gene	members|amod|START_ENTITY members|amod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
26306570	0	JAM-A	0,5	Cdc42	53,58	JAM-A	Cdc42	50848	998	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis .
23885123	0	JAM-A	0,5	ZO-2	22,26	JAM-A	ZO-2	16456(Tax:10090)	21873(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	JAM-A associates with ZO-2 , afadin , and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function .
23588236	0	JAM-A	59,64	junctional_adhesion_molecule-A	27,57	JAM-A	junctional adhesion molecule-A	50848	50848	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mast cell tryptase reduces junctional_adhesion_molecule-A -LRB- JAM-A -RRB- expression in intestinal epithelial cells : implications for the mechanisms of barrier_dysfunction in irritable_bowel_syndrome .
16195363	0	JAM-C	44,49	junctional_adhesion_molecule-C	12,42	JAM-C	junctional adhesion molecule-C	83700	83700	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of junctional_adhesion_molecule-C -LRB- JAM-C -RRB- in oxidized LDL-mediated leukocyte recruitment .
19060272	0	JAM-C	74,79	junctional_adhesion_molecule-C	42,72	JAM-C	junctional adhesion molecule-C	83700	83700	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression , localization , and function of junctional_adhesion_molecule-C -LRB- JAM-C -RRB- in human retinal pigment epithelium .
16767690	0	JAM-C	44,49	junctional_adhesion_molecule_C	12,42	JAM-C	junctional adhesion molecule C	83964(Tax:10090)	83964(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of junctional_adhesion_molecule_C -LRB- JAM-C -RRB- in acute pancreatitis .
19636912	0	JARID1C	102,109	SMCX	111,115	JARID1C	SMCX	8242	8242	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Backbone and sidechain 1H , 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C -LRB- SMCX -RRB- protein .
25331946	0	JAZ	0,3	p21	75,78	JAZ	p21	23567	1026	Gene	Gene	Protects|nsubj|START_ENTITY Protects|nmod|END_ENTITY	JAZ -LRB- Znf346 -RRB- , a SIRT1-interacting Protein , Protects Neurons by Stimulating p21 -LRB- WAF/CIP1 -RRB- Protein Expression .
24930994	0	JAZF1	0,5	visfatin	16,24	JAZF1	visfatin	221895	10135	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	JAZF1 regulates visfatin expression in adipocytes via PPARa and PPARb / signaling .
10903903	0	JBP1	36,40	Hsl7p	0,5	JBP1	Hsl7p	10419	852431(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Hsl7p , the yeast homologue of human JBP1 , is a protein methyltransferase .
20214788	0	JDP2	28,32	AP-1	4,8	JDP2	AP-1	81703(Tax:10090)	16476(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The AP-1 repressor protein , JDP2 , potentiates hepatocellular_carcinoma in mice .
23612584	0	JDP2	32,36	AP-1	14,18	JDP2	AP-1	81703(Tax:10090)	16476(Tax:10090)	Gene	Gene	overexpression|compound|START_ENTITY signaling|nmod|overexpression END_ENTITY|acl|signaling	Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction .
18396163	0	JDP2	22,26	CHOP	72,76	JDP2	CHOP	122953	1649	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|transcription transcription|nmod|END_ENTITY	Role of the repressor JDP2 in the amino_acid-regulated transcription of CHOP .
21525011	0	JDP2	43,47	Jun_dimerization_protein_2	15,41	JDP2	Jun dimerization protein 2	122953	122953	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Jun_dimerization_protein_2 -LRB- JDP2 -RRB- in the maintenance of Epstein-Barr_virus latency .
24582561	0	JDP2	104,108	doublecortin-like_protein_kinase	25,57	JDP2	doublecortin-like protein kinase	436766(Tax:7955)	572548(Tax:7955)	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Nuclear translocation of doublecortin-like_protein_kinase and phosphorylation of a transcription factor JDP2 .
25961985	0	JDP2	45,49	p16Ink4a	25,33	JDP2	p16Ink4a	81703(Tax:10090)	12578(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of p16Ink4a and Arf by JDP2 in cellular senescence .
10602419	0	JEM-1	0,5	AP-1	79,83	JEM-1	AP-1	8548	3725	Gene	Gene	START_ENTITY|dep|interaction interaction|nmod|END_ENTITY	JEM-1 , a novel nuclear co-factor : localisation and functional interaction with AP-1 .
11056056	0	JEM-1	28,33	BLZF1	35,40	JEM-1	BLZF1	8548	8548	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the JEM-1 -LRB- BLZF1 -RRB- gene on human chromosome 1q24 : molecular cloning and analysis of its promoter region .
15998322	0	JFC1	73,77	Akt	0,3	JFC1	Akt	84958	207	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation .
16254246	0	JIL-1_kinase	4,16	lamin_Dm0	32,41	JIL-1 kinase	lamin Dm0	39241(Tax:7227)	33782(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The JIL-1_kinase interacts with lamin_Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells .
9933567	0	JIP-1	135,140	c-Jun-amino-terminal_kinase_interacting_protein-1	84,133	JIP-1	c-Jun-amino-terminal kinase interacting protein-1	9479	9479	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization , fine-mapping , and expression of the human islet-brain_1 -LRB- IB1 -RRB- / c-Jun-amino-terminal_kinase_interacting_protein-1 -LRB- JIP-1 -RRB- gene .
9933567	0	JIP-1	135,140	islet-brain_1	64,77	JIP-1	islet-brain 1	9479	9479	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization , fine-mapping , and expression of the human islet-brain_1 -LRB- IB1 -RRB- / c-Jun-amino-terminal_kinase_interacting_protein-1 -LRB- JIP-1 -RRB- gene .
19036714	0	JIP-3	56,61	JNK	65,68	JIP-3	JNK	30957(Tax:10090)	26419(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage .
12756254	0	JIP1	22,26	JIP1	45,49	JIP1	JIP1	9479	9479	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation .
12756254	0	JIP1	45,49	JIP1	22,26	JIP1	JIP1	9479	9479	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation .
12756254	0	JIP1	22,26	JNK	15,18	JIP1	JNK	9479	5599	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation .
12756254	0	JIP1	45,49	JNK	15,18	JIP1	JNK	9479	5599	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation .
15141161	0	JIP1	81,85	JNK1	49,53	JIP1	JNK1	9479	5599	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|inhibition inhibition|nmod|END_ENTITY	Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 .
20508646	0	JIP1	0,4	RBP-Jk	16,22	JIP1	RBP-Jk	9479	3516	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway .
19211056	0	JIP4	20,24	ARF6	0,4	JIP4	ARF6	9043	382	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis .
19644450	0	JIP4	98,102	ARF6	75,79	JIP4	ARF6	9043	382	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The structural basis of Arf effector specificity : the crystal structure of ARF6 in a complex with JIP4 .
24973512	0	JK-1	13,17	FAM134B	19,26	JK-1	FAM134B	54463	54463	Gene	Gene	expressions|amod|START_ENTITY expressions|appos|END_ENTITY	The roles of JK-1 -LRB- FAM134B -RRB- expressions in colorectal_cancer .
15987681	0	JLP	0,3	kinesin_light_chain_1	20,41	JLP	kinesin light chain 1	9043	3831	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	JLP associates with kinesin_light_chain_1 through a novel leucine zipper-like domain .
26279298	0	JMJD1A	58,64	c-Myc	14,19	JMJD1A	c-Myc	55818	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate_cancer cell growth and survival .
26731476	0	JMJD2A	20,26	ETV1	86,90	JMJD2A	ETV1	9682	2115	Gene	Gene	drives|nsubj|START_ENTITY drives|nmod|END_ENTITY	Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1 .
17555712	0	JMJD2A	56,62	androgen_receptor	14,31	JMJD2A	androgen receptor	9682	367	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of androgen_receptor by histone demethylases JMJD2A and JMJD2D .
25607726	0	JMJD2B	124,130	PARP1	91,96	JMJD2B	PARP1	23030	142	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Emodin attenuates radioresistance induced by hypoxia in HepG2 cells via the enhancement of PARP1 cleavage and inhibition of JMJD2B .
20682797	0	JMJD2B	24,30	estrogen_receptor_alpha	47,70	JMJD2B	estrogen receptor alpha	23030	2099	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The histone demethylase JMJD2B is regulated by estrogen_receptor_alpha and hypoxia , and is a key mediator of estrogen induced growth .
23376847	0	JMJD2b	57,63	p53	0,3	JMJD2b	p53	23030	7157	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression .
25079229	0	JMJD3	75,80	Jumonji_D3	63,73	JMJD3	Jumonji D3	216850(Tax:10090)	216850(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Stage-dependent and locus-specific role of histone demethylase Jumonji_D3 -LRB- JMJD3 -RRB- in the embryonic stages of lung development .
24726732	0	JMJD3	17,22	MIR146A	0,7	JMJD3	MIR146A	23135	406938	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MIR146A inhibits JMJD3 expression and osteogenic differentiation in human mesenchymal stem cells .
23711388	0	JMJD3	49,54	THP-1	93,98	JMJD3	THP-1	23135	2736	Gene	Gene	START_ENTITY|nmod|cells cells|appos|END_ENTITY	Proteomic changes induced by histone demethylase JMJD3 in TNF_alpha-treated human monocytic -LRB- THP-1 -RRB- cells .
21358285	0	JMJD5	0,5	TOC1	32,36	JMJD5	TOC1	79831	836259(Tax:3702)	Gene	Gene	Functions|compound|START_ENTITY Functions|nmod|END_ENTITY	JMJD5 Functions in concert with TOC1 in the arabidopsis circadian system .
26025680	0	JMJD5	0,5	p53	21,24	JMJD5	p53	79831	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	JMJD5 interacts with p53 and negatively regulates p53 function in control of cell cycle and proliferation .
26896934	0	JMJD6	47,52	Jumonji_C-domain_containing_protein_6	8,45	JMJD6	Jumonji C-domain containing protein 6	23210	23210	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Jumonji_C-domain_containing_protein_6 -LRB- JMJD6 -RRB- in infectivity of foot-and-mouth_disease virus .
17170761	0	JMY	44,47	Mdm2	0,4	JMY	Mdm2	57748(Tax:10090)	17246(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Mdm2 targets the p53 transcription cofactor JMY for degradation .
25244799	0	JNK	64,67	ALDH2	26,31	JNK	ALDH2	116554(Tax:10116)	24188(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of activation of ALDH2 by ethanol on the expression of JNK in kidney of diabetic rats -RSB- .
12663670	0	JNK	45,48	ATF2	146,150	JNK	ATF2	5599	1386	Gene	Gene	kinase|appos|START_ENTITY activation|nmod|kinase serves|nsubj|activation serves|xcomp|promote promote|dobj|resistance resistance|nmod|activating_transcription_factor_2 activating_transcription_factor_2|appos|END_ENTITY	The activation of c-Jun NH2-terminal kinase -LRB- JNK -RRB- by DNA-damaging agents serves to promote drug resistance via activating_transcription_factor_2 -LRB- ATF2 -RRB- - dependent enhanced DNA repair .
21384452	0	JNK	17,20	ATF2	79,83	JNK	ATF2	5599	1386	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nmod|interaction interaction|nmod|JNK JNK|nummod|END_ENTITY	GST pi modulates JNK activity through a direct interaction with JNK substrate , ATF2 .
7824938	0	JNK	44,47	ATF2	21,25	JNK	ATF2	5599	1386	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Transcription factor ATF2 regulation by the JNK signal transduction pathway .
16132952	0	JNK	100,103	Akt	131,134	JNK	Akt	5599	207	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Nitric_oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt .
18402055	0	JNK	16,19	Akt	53,56	JNK	Akt	116554(Tax:10116)	24185(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY suppressed|nsubj|activation suppressed|nmod|END_ENTITY	Ethanol-induced JNK activation suppressed via active Akt in hepatocytes .
19526300	0	JNK	155,158	Akt	124,127	JNK	Akt	116554(Tax:10116)	24185(Tax:10116)	Gene	Gene	kinases|compound|START_ENTITY Protection|nmod|kinases Protection|nmod|activation activation|nmod|pathway pathway|amod|END_ENTITY	Protection against chronic hypoperfusion-induced retinal_neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases .
19768546	0	JNK	141,144	Akt	103,106	JNK	Akt	5599	207	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK .
24820448	0	JNK	120,123	Akt	82,85	JNK	Akt	5599	207	Gene	Gene	kinase|dobj|START_ENTITY kinase|dobj|END_ENTITY	Human cord blood stem cell paracrine factors activate the survival protein kinase Akt and inhibit death protein kinases JNK and p38 in injured cardiomyocytes .
25275048	0	JNK	14,17	Akt	111,114	JNK	Akt	5599	207	Gene	Gene	Inhibition|nmod|START_ENTITY potentiates|nsubj|Inhibition potentiates|nmod|cells cells|nmod|suppression suppression|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Inhibition of JNK potentiates temozolomide-induced cytotoxicity in U87MG glioblastoma cells via suppression of Akt phosphorylation .
26126628	0	JNK	111,114	Angiotensin_II	0,14	JNK	Angiotensin II	116554(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
26069075	0	JNK	59,62	Angptl4	25,32	JNK	Angptl4	26419(Tax:10090)	57875(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Expression|nmod|Pathway Expression|compound|END_ENTITY	Interleukin-1b Increases Angptl4 -LRB- FIAF -RRB- Expression via the JNK Signaling Pathway in Osteoblastic MC3T3-E1 Cells .
12189144	0	JNK	0,3	BAD	38,41	JNK	BAD	116554(Tax:10116)	64639(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery .
14967141	0	JNK	0,3	BAD	86,89	JNK	BAD	5599	572	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|apoptosis apoptosis|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD .
19681889	0	JNK	18,21	BAG3	130,134	JNK	BAG3	5599	9531	Gene	Gene	signalling|compound|START_ENTITY Inhibition|nmod|signalling enhances|nsubj|Inhibition enhances|nmod|suppression suppression|nmod|expression expression|compound|END_ENTITY	Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney_cancer cells by suppression of BAG3 expression .
22020323	0	JNK	15,18	BAG3	74,78	JNK	BAG3	5599	9531	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|expression expression|compound|END_ENTITY	Involvement of JNK and NF-kB pathways in lipopolysaccharide -LRB- LPS -RRB- - induced BAG3 expression in human monocytic cells .
23395971	0	JNK	56,59	BAG3	29,33	JNK	BAG3	5599	9531	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	The combination of silencing BAG3 and inhibition of the JNK pathway enhances hyperthermia sensitivity in human oral_squamous_cell_carcinoma cells .
16158421	0	JNK	33,36	Bak	17,20	JNK	Bak	5599	578	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of Bak and Bim via JNK downstream pathway in the response to nitric_oxide in human glioblastoma cells .
12879014	0	JNK	53,56	Bax	82,85	JNK	Bax	5599	581	Gene	Gene	pathway|appos|START_ENTITY activation|nmod|pathway fails|nsubj|activation fails|xcomp|elicit elicit|dobj|activation activation|compound|END_ENTITY	Selective activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3 ' - kinase -LRB- PI3K -RRB- pathway is inhibited .
15071501	0	JNK	0,3	Bax	13,16	JNK	Bax	5599	581	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|translocation translocation|compound|END_ENTITY	JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins .
16243436	0	JNK	166,169	Bax	113,116	JNK	Bax	116554(Tax:10116)	24887(Tax:10116)	Gene	Gene	c-Jun_N-terminal_kinase|appos|START_ENTITY mediated|nmod|c-Jun_N-terminal_kinase mediated|nsubjpass|dimmers dimmers|amod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16243436	0	JNK	166,169	Bax	98,101	JNK	Bax	116554(Tax:10116)	24887(Tax:10116)	Gene	Gene	c-Jun_N-terminal_kinase|appos|START_ENTITY mediated|nmod|c-Jun_N-terminal_kinase mediated|nsubjpass|dimmers dimmers|dep|expression expression|appos|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
16458303	0	JNK	58,61	Bax	18,21	JNK	Bax	5599	581	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	The regulation of Bax by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- is a prerequisite to the mitochondrial-induced apoptotic pathway .
16709574	0	JNK	0,3	Bax	48,51	JNK	Bax	5599	581	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	JNK - and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells .
17113036	0	JNK	40,43	Bax	86,89	JNK	Bax	5599	581	Gene	Gene	signaling|nsubj|START_ENTITY signaling|dobj|activation activation|nmod|END_ENTITY	PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax .
18636161	0	JNK	108,111	Bax	62,65	JNK	Bax	5599	581	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
20709060	0	JNK	4,7	Bax	89,92	JNK	Bax	5599	581	Gene	Gene	SP600125|compound|START_ENTITY enhances|nsubj|SP600125 enhances|advcl|accelerating accelerating|dobj|translocation translocation|compound|END_ENTITY	The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung_adenocarcinoma cells .
15467450	0	JNK	0,3	Bcl-2	23,28	JNK	Bcl-2	5599	596	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	JNK is associated with Bcl-2 and PP1 in mitochondria : paclitaxel induces its activation and its association with the phosphorylated form of Bcl-2 .
22822094	0	JNK	16,19	Bcl-2	64,69	JNK	Bcl-2	5599	596	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	ROS-independent JNK activation and multisite phosphorylation of Bcl-2 link diallyl_tetrasulfide-induced mitotic_arrest to apoptosis .
17869087	0	JNK	148,151	Bcl-XL	123,129	JNK	Bcl-XL	116554(Tax:10116)	24888(Tax:10116)	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	Piceatannol attenuates hydrogen-peroxide - and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK .
18636161	0	JNK	108,111	Bcl-xL	34,40	JNK	Bcl-xL	5599	598	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR .
18758060	0	JNK	157,160	Bcl-xL	113,119	JNK	Bcl-xL	5599	598	Gene	Gene	cells|appos|START_ENTITY regulation|nmod|cells regulation|appos|END_ENTITY	Differential regulation of the antiapoptotic action of B-cell_lymphoma_2 -LRB- Bcl-2 -RRB- and B-cell_lymphoma extra long -LRB- Bcl-xL -RRB- by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 1-involved pathway in neuroglioma cells .
16771680	0	JNK	25,28	C-Jun_N-terminal_kinase	0,23	JNK	C-Jun N-terminal kinase	5599	5599	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	C-Jun_N-terminal_kinase -LRB- JNK -RRB- regulation of iNOS expression in glial cells : predominant role of JNK1 isoform .
14627919	0	JNK	25,28	C-jun_N-terminal_kinase	0,23	JNK	C-jun N-terminal kinase	5599	5599	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	C-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitor , SP600125 , blocks interleukin _ -LRB- IL -RRB- -6 - induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- production : cyclosporine_A partially mimics this inhibitory effect .
22410671	0	JNK	50,53	CCL2	30,34	JNK	CCL2	116554(Tax:10116)	24770(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	Curcumin inhibits LPS-induced CCL2 expression via JNK pathway in C6 rat astrocytoma cells .
15496400	0	JNK	23,26	CYLD	61,65	JNK	CYLD	5599	1540	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Negative regulation of JNK signaling by the tumor suppressor CYLD .
21448133	0	JNK	24,27	CYLD	76,80	JNK	CYLD	5599	1540	Gene	Gene	activation|compound|START_ENTITY requires|nsubj|activation requires|dobj|inactivation inactivation|nmod|END_ENTITY	T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1 .
19546888	0	JNK	25,28	Cbl	0,3	JNK	Cbl	5599	867	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Cbl negatively regulates JNK activation and cell death .
26772997	0	JNK	36,39	Cindr	20,25	JNK	Cindr	44801(Tax:7227)	43654(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The adaptor protein Cindr regulates JNK activity to maintain epithelial sheet integrity .
10777559	0	JNK	18,21	Crk	0,3	JNK	Crk	26419(Tax:10090)	12928(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|dobj|activation	Crk activation of JNK via C3G and R-Ras .
20510502	0	JNK	87,90	DJ-1	0,4	JNK	DJ-1	5599	11315	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	DJ-1 , a cancer and Parkinson 's _ disease associated protein , regulates autophagy through JNK pathway in cancer cells .
12198495	0	JNK	88,91	DTRAF1	44,50	JNK	DTRAF1	44801(Tax:7227)	33638(Tax:7227)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila .
11104676	0	JNK	108,111	ERK	74,77	JNK	ERK	26419(Tax:10090)	26413(Tax:10090)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Compartment-specific regulation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- mitogen-activated protein kinases -LRB- MAPKs -RRB- by ERK-dependent and non-ERK-dependent inductions of MAPK_phosphatase _ -LRB- MKP -RRB- -3 and MKP-1 in differentiating P19 cells .
11330828	0	JNK	165,168	ERK	131,134	JNK	ERK	5599	5594	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Insulin regulates MAP kinase phosphatase-1 induction in Hirc B cells via activation of both extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun-N-terminal_kinase -LRB- JNK -RRB- .
12237195	0	JNK	147,150	ERK	113,116	JNK	ERK	116554(Tax:10116)	24338(Tax:10116)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus .
14667452	0	JNK	109,112	ERK	75,78	JNK	ERK	5599	5594	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Nitric_oxide-mediated activation of extracellular signal-regulated kinase -LRB- ERK -RRB- and c-jun_N-terminal_kinase -LRB- JNK -RRB- during hypoxia in cerebral cortical nuclei of newborn piglets .
20432452	0	JNK	145,148	ERK	140,143	JNK	ERK	5599	5594	Gene	Gene	AP-1|appos|START_ENTITY AP-1|compound|END_ENTITY	Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid_arthritis synovial fibroblasts : involvement of ERK , JNK , AP-1 , and NF-kappaB .
21604264	0	JNK	15,18	ERK	37,40	JNK	ERK	5599	5594	Gene	Gene	pathway|nmod|START_ENTITY decreased|nsubj|pathway decreased|dobj|activities activities|compound|END_ENTITY	A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation .
22689214	0	JNK	40,43	ERK	45,48	JNK	ERK	5599	5594	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Effect of HSP70 and 90 in modulation of JNK , ERK expression in preeclamptic placental endothelial cell .
9362525	0	JNK	131,134	ERK	97,100	JNK	ERK	5599	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|extracellular_signal-regulated_kinase extracellular_signal-regulated_kinase|dep|END_ENTITY	Cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA-4 -RRB- interferes with extracellular_signal-regulated_kinase -LRB- ERK -RRB- and Jun_NH2-terminal_kinase -LRB- JNK -RRB- activation , but does not affect phosphorylation of T cell receptor zeta and ZAP70 .
15454338	0	JNK	75,78	ERK1/2	116,122	JNK	ERK1/2	26419(Tax:10090)	5595;5594	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Protective effects of SP600125 a new inhibitor of c-jun N-terminal kinase -LRB- JNK -RRB- and extracellular-regulated kinase -LRB- ERK1/2 -RRB- in an experimental model of cerulein-induced pancreatitis .
15778501	0	JNK	115,118	FAK	125,128	JNK	FAK	5599	5747	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix : JNK links FAK and p53 .
21604264	0	JNK	15,18	FOXO3a	64,70	JNK	FOXO3a	5599	2309	Gene	Gene	pathway|nmod|START_ENTITY decreased|nsubj|pathway decreased|nmod|translocation translocation|amod|END_ENTITY	A pathway from JNK through decreased ERK and Akt activities for FOXO3a nuclear translocation in response to UV irradiation .
22297293	0	JNK	0,3	FOXO3a	14,20	JNK	FOXO3a	116554(Tax:10116)	294515(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart_failure .
26947074	0	JNK	68,71	Fibroblast_Growth_Factor_21	0,27	JNK	Fibroblast Growth Factor 21	26419(Tax:10090)	56636(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Fibroblast_Growth_Factor_21 Mediates Glycemic Regulation by Hepatic JNK .
15569384	0	JNK	76,79	Foxo3a	0,6	JNK	Foxo3a	5599	2309	Gene	Gene	cooperation|nmod|START_ENTITY pathway|nmod|cooperation induces|nmod|pathway induces|nsubj|END_ENTITY	Foxo3a induces motoneuron death through the Fas pathway in cooperation with JNK .
22068640	0	JNK	26,29	GSTP1-1	10,17	JNK	GSTP1-1	5599	2950	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and - resistant human osteosarcoma cell lines .
17428471	0	JNK	100,103	Gadd45a	0,7	JNK	Gadd45a	26419(Tax:10090)	13197(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Gadd45a , the gene induced by the mood stabilizer valproic_acid , regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells .
12135322	0	JNK	48,51	Galpha13	0,8	JNK	Galpha13	5599	10672	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Galpha13 induces preproET-1 gene expression via JNK .
14766760	0	JNK	0,3	HIPK3	14,19	JNK	HIPK3	5599	10114	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate_carcinoma cells .
21985290	0	JNK	100,103	HO-1	121,125	JNK	HO-1	26419(Tax:10090)	15368(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute_hepatic_injury through JNK pathway-mediated HO-1 expression .
24366007	0	JNK	47,50	HO-1	17,21	JNK	HO-1	5599	3162	Gene	Gene	activating|dobj|START_ENTITY induces|advcl|activating induces|dobj|expression expression|compound|END_ENTITY	Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53 .
18348256	0	JNK	51,54	HSP70	27,32	JNK	HSP70	26419(Tax:10090)	15511(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Differential regulation of HSP70 expression by the JNK kinases SEK1 and MKK7 in mouse embryonic_stem cells treated with cadmium .
22409343	0	JNK	13,16	HSP70	48,53	JNK	HSP70	5599	3308	Gene	Gene	Mechanism|nmod|START_ENTITY signal|nsubj|Mechanism signal|nmod|END_ENTITY	Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia .
22689214	0	JNK	40,43	HSP70	10,15	JNK	HSP70	5599	3308	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of HSP70 and 90 in modulation of JNK , ERK expression in preeclamptic placental endothelial cell .
21561986	0	JNK	37,40	Hipk	72,76	JNK	Hipk	44801(Tax:7227)	38070(Tax:7227)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus .
9821948	0	JNK	45,48	Hsp70	8,13	JNK	Hsp70	5599	3308	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of Hsp70 in regulation of stress-kinase JNK : implications in apoptosis and aging .
15996190	0	JNK	109,112	IL-1beta	72,80	JNK	IL-1beta	5599	3553	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|dobj|expression expression|compound|END_ENTITY	Actinobacillus_actinomycetemcomitans Y4 capsular polysaccharide induces IL-1beta mRNA expression through the JNK pathway in differentiated THP-1 cells .
18228247	0	JNK	56,59	IL-6	27,31	JNK	IL-6	26419(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	TLR7 and CD40 cooperate in IL-6 production via enhanced JNK and AP-1 activation .
24752352	0	JNK	133,136	IL-6	0,4	JNK	IL-6	5599	3569	Gene	Gene	pathway|compound|START_ENTITY mediated|nmod|pathway cells|acl|mediated upregulates|nmod|cells upregulates|dep|END_ENTITY	IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 -LRB- ADAMTS-2 -RRB- in human osteosarcoma cells mediated by JNK pathway .
18607537	0	JNK	45,48	IL-8	0,4	JNK	IL-8	5599	3576	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	IL-8 and p53 are inversely regulated through JNK , p38 and NF-kappaB_p65 in HepG2 cells during an inflammatory response .
20714405	0	JNK	9,12	IL1RAPL1	60,68	JNK	IL1RAPL1	26419(Tax:10090)	331461(Tax:10090)	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	Neuronal JNK pathway activation by IL-1 is mediated through IL1RAPL1 , a protein required for development of cognitive functions .
23666852	0	JNK	36,39	IRF4	0,4	JNK	IRF4	5599	3662	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	IRF4 promotes cell proliferation by JNK pathway in multiple myeloma .
18704119	0	JNK	24,27	IkappaB_kinase_2	61,77	JNK	IkappaB kinase 2	26419(Tax:10090)	16150(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB_kinase_2 to prevent endotoxin-induced liver_failure .
19036714	0	JNK	65,68	JIP-3	56,61	JNK	JIP-3	26419(Tax:10090)	30957(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage .
12756254	0	JNK	15,18	JIP1	22,26	JNK	JIP1	5599	9479	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation .
12756254	0	JNK	15,18	JIP1	45,49	JNK	JIP1	5599	9479	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation .
11476966	0	JNK	33,36	Jun_N-terminal_kinase	10,31	JNK	Jun N-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Prolonged Jun_N-terminal_kinase -LRB- JNK -RRB- activation and the upregulation of p53 and p21 -LRB- WAF1/CIP1 -RRB- preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin .
15536494	0	JNK	37,40	Jun_N-terminal_kinase	14,35	JNK	Jun N-terminal kinase	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Jun_N-terminal_kinase -LRB- JNK -RRB- enhances glucocorticoid receptor-mediated function in mouse hippocampal HT22 cells .
9415029	0	JNK	21,24	L-selectin	0,10	JNK	L-selectin	5599	6402	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac .
17848570	0	JNK	54,57	MAPK_phosphatase-1	8,26	JNK	MAPK phosphatase-1	5599	1843	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of MAPK_phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells .
16186362	0	JNK	0,3	MCP-1	14,19	JNK	MCP-1	5599	6347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	JNK regulates MCP-1 expression in adenovirus type 19-infected human corneal fibroblasts .
24086554	0	JNK	149,152	MCP-1	84,89	JNK	MCP-1	5599	6347	Gene	Gene	inactivation|nmod|START_ENTITY production|nmod|inactivation production|compound|END_ENTITY	Febuxostat , an inhibitor of xanthine oxidase , suppresses lipopolysaccharide-induced MCP-1 production via MAPK_phosphatase-1-mediated inactivation of JNK .
24966899	0	JNK	118,121	MCP-1	49,54	JNK	MCP-1	5599	6347	Gene	Gene	pathways|compound|START_ENTITY stimulates|nmod|pathways stimulates|dobj|secretion secretion|nmod|END_ENTITY	TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-kB signal pathways .
17078934	0	JNK	32,35	MEKK-1	25,31	JNK	MEKK-1	5599	4214	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Divergent effects of the MEKK-1 / JNK pathway on NB2a/d1 differentiation : some activity is required for outgrowth and stabilization of neurites but overactivation inhibits both phenomena .
11278622	0	JNK	49,52	MEKK2	0,5	JNK	MEKK2	5599	10746	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression .
16802349	0	JNK	14,17	MKK-7	21,26	JNK	MKK-7	5599	5609	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of JNK by MKK-7 in fibroblast-like synoviocytes .
17187786	0	JNK	45,48	MKK4	28,32	JNK	MKK4	5599	6416	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|END_ENTITY	Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins .
21333379	0	JNK	18,21	MKK4	77,81	JNK	MKK4	5599	6416	Gene	Gene	signaling|compound|START_ENTITY bottleneck|nmod|signaling bottleneck|dep|characteristics characteristics|nmod|END_ENTITY	The bottleneck of JNK signaling : molecular and functional characteristics of MKK4 and MKK7 .
25244576	0	JNK	76,79	MKK4	150,154	JNK	MKK4	5599	6416	Gene	Gene	affinity|appos|START_ENTITY affinity|dep|protein protein|nmod|END_ENTITY	Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase -LRB- JNK -RRB- - interacting protein 4 for mitogen-activated_protein_kinase_kinase_4 -LRB- MKK4 -RRB- and suppresses the phosphorylation of MKK4 , p38 , and JNK , thereby inhibiting apoptosis .
25244576	0	JNK	76,79	MKK4	194,198	JNK	MKK4	5599	6416	Gene	Gene	affinity|appos|START_ENTITY affinity|nmod|END_ENTITY	Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase -LRB- JNK -RRB- - interacting protein 4 for mitogen-activated_protein_kinase_kinase_4 -LRB- MKK4 -RRB- and suppresses the phosphorylation of MKK4 , p38 , and JNK , thereby inhibiting apoptosis .
22182512	0	JNK	31,34	MKP-7	0,5	JNK	MKP-7	5599	80824	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
23280045	0	JNK	44,47	MKP-7	61,66	JNK	MKP-7	116554(Tax:10116)	297682(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral_ischemia in rat hippocampus .
22082235	0	JNK	111,114	MMP-2	90,95	JNK	MMP-2	5599	4313	Gene	Gene	signaling|compound|START_ENTITY expression|nmod|signaling expression|compound|END_ENTITY	EGCG inhibits the invasion of highly invasive CL1-5 lung_cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest .
17106880	0	JNK	50,53	MMP1	94,98	JNK	MMP1	5599	4312	Gene	Gene	activation|appos|START_ENTITY upregulates|nsubj|activation upregulates|dobj|mRNA mRNA|compound|END_ENTITY	Oxidative stress-induced c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation in tendon cells upregulates MMP1 mRNA and protein expression .
25955575	0	JNK	153,156	Matrix_Metalloproteinase_2	38,64	JNK	Matrix Metalloproteinase 2	5599	4313	Gene	Gene	Cells|nmod|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	Angiotensin_II Induces an Increase in Matrix_Metalloproteinase_2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic_Aneurysms Through JNK , ERK1/2 , and p38 MAPK Activation .
25955575	0	JNK	153,156	Matrix_Metalloproteinase_2	38,64	JNK	Matrix Metalloproteinase 2	5599	4313	Gene	Gene	Cells|nmod|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	Angiotensin_II Induces an Increase in Matrix_Metalloproteinase_2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic_Aneurysms Through JNK , ERK1/2 , and p38 MAPK Activation .
19888449	0	JNK	93,96	Mkk4	36,40	JNK	Mkk4	44801(Tax:7227)	41020(Tax:7227)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK .
17082773	0	JNK	0,3	Mmp1	23,27	JNK	Mmp1	44801(Tax:7227)	37949(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	JNK - and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila .
21504622	0	JNK	24,27	NAG-1	14,19	JNK	NAG-1	5599	9518	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP_prostate_cancer cells .
15913957	0	JNK	9,12	NESK	27,31	JNK	NESK	5599	203447	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Enhanced JNK activation by NESK without kinase activity upon caspase-mediated cleavage during apoptosis .
16483929	0	JNK	37,40	NF-kappaB	0,9	JNK	NF-kappaB	26419(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta .
10484329	0	JNK	0,3	Na-K-2Cl_cotransporter	57,79	JNK	Na-K-2Cl cotransporter	5599	6558	Gene	Gene	kinase|nsubj|START_ENTITY kinase|acl:relcl|phosphorylates phosphorylates|dobj|END_ENTITY	JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl_cotransporter in vitro .
24362969	0	JNK	147,150	P2Y2	124,128	JNK	P2Y2	5599	5029	Gene	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute_liver_failure is modulated by P2Y2 receptor-mediated JNK activation .
26740179	0	JNK	104,107	PDK4	56,60	JNK	PDK4	26419(Tax:10090)	27273(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Inflammation increases pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- expression via the Jun N-Terminal Kinase -LRB- JNK -RRB- pathway in C2C12 cells .
15596544	0	JNK	38,41	PINCH	22,27	JNK	PINCH	44801(Tax:7227)	40999(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras_suppressor_1 .
14709334	0	JNK	67,70	PKC-alpha	20,29	JNK	PKC-alpha	5599	5578	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|END_ENTITY	Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung_cancer cells .
16339571	0	JNK	83,86	PTX3	32,36	JNK	PTX3	5599	5806	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK .
16061178	0	JNK	29,32	RACK1	0,5	JNK	RACK1	26419(Tax:10090)	14694(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	RACK1 mediates activation of JNK by protein_kinase_C -LSB- corrected -RSB- .
26137143	0	JNK	32,35	RACK1	0,5	JNK	RACK1	5599	10399	Gene	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|expression expression|compound|END_ENTITY	RACK1 expression contributes to JNK activity , but JNK activity does not enhance RACK1 expression in hepatocellular_carcinoma SMMC-7721 cells .
26137143	0	JNK	50,53	RACK1	80,85	JNK	RACK1	5599	10399	Gene	Gene	activity|compound|START_ENTITY enhance|nsubj|activity enhance|dobj|expression expression|nummod|END_ENTITY	RACK1 expression contributes to JNK activity , but JNK activity does not enhance RACK1 expression in hepatocellular_carcinoma SMMC-7721 cells .
21278800	0	JNK	42,45	RASSF7	0,6	JNK	RASSF7	5599	8045	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7 .
16597320	0	JNK	80,83	RIP1	50,54	JNK	RIP1	379876(Tax:8355)	734234(Tax:8355)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB .
16142755	0	JNK	92,95	STAT-6	65,71	JNK	STAT-6	26419(Tax:10090)	20852(Tax:10090)	Gene	Gene	blockade|nmod|START_ENTITY END_ENTITY|nmod|blockade	Inhibition of inflammatory bone_erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation .
10400627	0	JNK	64,67	Shc	0,3	JNK	Shc	5599	6464	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Shc regulates epidermal growth factor-induced activation of the JNK signaling pathway .
21561986	0	JNK	37,40	Smt3	11,15	JNK	Smt3	44801(Tax:7227)	33981(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus .
10634792	0	JNK	14,17	Src	21,24	JNK	Src	44801(Tax:7227)	48973(Tax:7227)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of JNK by Src during Drosophila development .
10766791	0	JNK	20,23	Src	0,3	JNK	Src	26419(Tax:10090)	20779(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species .
16311020	0	JNK	57,60	TAB2	11,15	JNK	TAB2	44801(Tax:7227)	37216(Tax:7227)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB .
15260968	0	JNK	0,3	TGF-beta1	52,61	JNK	TGF-beta1	5599	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|nmod|END_ENTITY	JNK regulates expression and autocrine signaling of TGF-beta1 .
15260977	0	JNK	0,3	TGF-beta1	38,47	JNK	TGF-beta1	26419(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	JNK regulates autocrine expression of TGF-beta1 .
11353829	0	JNK	52,55	TNF-alpha	28,37	JNK	TNF-alpha	5599	7124	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells : Inhibitory crosstalk among MAPK family members .
16516830	0	JNK	71,74	TNF-alpha	20,29	JNK	TNF-alpha	5599	7124	Gene	Gene	action|compound|START_ENTITY determines|dobj|action factor|dep|determines itch|dep|factor itch|nmod|cytotoxicity cytotoxicity|amod|END_ENTITY	A five-year itch in TNF-alpha cytotoxicity : the time factor determines JNK action .
18097057	0	JNK	54,57	TNF-alpha	28,37	JNK	TNF-alpha	5599	7124	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|Activation Activation|nmod|kinase kinase|nmod|END_ENTITY	Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells .
18297686	0	JNK	83,86	TNF-alpha	0,9	JNK	TNF-alpha	5599	7124	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling keratinocytes|nmod|activation represses|nmod|keratinocytes represses|nsubj|END_ENTITY	TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling .
20371967	0	JNK	33,36	TNF-alpha	81,90	JNK	TNF-alpha	26419(Tax:10090)	21926(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|acl|regulating regulating|dobj|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|appos|END_ENTITY	Role of c-Jun N-terminal kinase -LRB- JNK -RRB- in regulating tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- mediated increase of acetaminophen -LRB- APAP -RRB- and chlorpromazine -LRB- CPZ -RRB- toxicity in murine hepatocytes .
12502848	0	JNK	33,36	TRAF1	0,5	JNK	TRAF1	5599	7185	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr_virus-encoded latent infection membrane protein 1 but not CD40 .
26610752	0	JNK	15,18	TRAF2	0,5	JNK	TRAF2	116554(Tax:10116)	311786(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TRAF2 mediates JNK and STAT3 activation in response to IL-1b and IFNy and facilitates apoptotic death of insulin-producing b-cells .
9390693	0	JNK	23,26	TRAF2	0,5	JNK	TRAF2	5599	7186	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival .
16157600	0	JNK	48,51	TRAF4	38,43	JNK	TRAF4	5599	9618	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	MEKK4 is an effector of the embryonic TRAF4 for JNK activation .
16955144	0	JNK	24,27	TRAIL	0,5	JNK	TRAIL	26419(Tax:10090)	22035(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver_damage and lethality .
23857473	0	JNK	123,126	TRAIL	66,71	JNK	TRAIL	5599	8743	Gene	Gene	p38|nmod|START_ENTITY activation|nmod|p38 receptors|nmod|activation receptors|amod|END_ENTITY	CAPE promotes TRAIL-induced apoptosis through the upregulation of TRAIL receptors via activation of p38 and suppression of JNK in SK-Hep1 hepatocellular carcinoma cells .
25446254	0	JNK	16,19	TRAIL	0,5	JNK	TRAIL	5599	8743	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TRAIL activates JNK and NF-kB through RIP1-dependent and - independent pathways .
20680486	0	JNK	38,41	TrkA	84,88	JNK	TrkA	5599	4914	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Control of TrkA-induced cell death by JNK activation and differential expression of TrkA upon DNA damage .
23946597	0	JNK	33,36	Tumor_necrosis_factor-a	0,23	JNK	Tumor necrosis factor-a	116554(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Tumor_necrosis_factor-a mediates JNK activation response to intestinal_ischemia-reperfusion injury .
18032781	0	JNK	104,107	VCAM-1	78,84	JNK	VCAM-1	5599	7412	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Activation of thromboxane receptor upregulates interleukin -LRB- IL -RRB- -1 beta-induced VCAM-1 expression through JNK signaling .
22182512	0	JNK	31,34	VCAM-1	46,52	JNK	VCAM-1	5599	7412	Gene	Gene	regulator|nmod|START_ENTITY MKP-7|appos|regulator regulates|nsubj|MKP-7 regulates|dobj|expression expression|compound|END_ENTITY	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
25496994	0	JNK	0,3	VMAT2	18,23	JNK	VMAT2	5599	6571	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron_death .
11751577	0	JNK	0,3	Wnt	35,38	JNK	Wnt	44801(Tax:7227)	32838(Tax:7227)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates .
21364637	0	JNK	0,3	Yes-associated_protein	19,41	JNK	Yes-associated protein	5599	10413	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	JNK phosphorylates Yes-associated_protein -LRB- YAP -RRB- to regulate apoptosis .
12054679	0	JNK	88,91	angiotensin_II	51,65	JNK	angiotensin II	116554(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Quercetin glucuronide prevents VSMC hypertrophy by angiotensin_II via the inhibition of JNK and AP-1 signaling pathway .
17060633	0	JNK	25,28	beta-catenin	47,59	JNK	beta-catenin	379876(Tax:8355)	399274(Tax:8355)	Gene	Gene	Jun_NH2-terminal_kinase|appos|START_ENTITY prevents|nsubj|Jun_NH2-terminal_kinase prevents|dobj|accumulation accumulation|amod|END_ENTITY	Jun_NH2-terminal_kinase -LRB- JNK -RRB- prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos .
19667122	0	JNK	0,3	beta-catenin	19,31	JNK	beta-catenin	5599	1499	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	JNK phosphorylates beta-catenin and regulates adherens junctions .
24457077	0	JNK	25,28	c-JUN	0,5	JNK	c-JUN	5599	3725	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	c-JUN N-terminal kinase -LRB- JNK -RRB- is activated and contributes to tumor cell proliferation in classical Hodgkin_lymphoma .
15721365	0	JNK	41,44	c-Jun	14,19	JNK	c-Jun	5599	3725	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Activation of c-Jun NH2-terminal kinase -LRB- JNK -RRB- signaling pathway is essential for the stimulation of hepatitis_C_virus _ -LRB- HCV -RRB- non-structural protein 3 -LRB- NS3 -RRB- - mediated cell growth .
19116455	0	JNK	65,68	c-Jun	77,82	JNK	c-Jun	26419(Tax:10090)	16476(Tax:10090)	Gene	Gene	activated|nmod|START_ENTITY activated|nmod|END_ENTITY	Transcription of the protein_kinase_C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin .
24471892	0	JNK	69,72	c-Jun	87,92	JNK	c-Jun	5599	3725	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Procyanidin induces apoptosis of esophageal_adenocarcinoma cells via JNK activation of c-Jun .
27080425	0	JNK	48,51	c-Jun-NH2-terminal_kinase	21,46	JNK	c-Jun-NH2-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of spinal c-Jun-NH2-terminal_kinase -LRB- JNK -RRB- improves locomotor activity of spinal cord injured rats .
24763745	0	JNK	33,36	c-Jun_N-Terminal_Kinase	8,31	JNK	c-Jun N-Terminal Kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	Activation|appos|START_ENTITY Activation|amod|END_ENTITY	Role of c-Jun_N-Terminal_Kinase -LRB- JNK -RRB- Activation in Micturition Reflexes in Cyclophosphamide -LRB- CYP -RRB- - Induced Cystitis in Female Rats .
11287640	0	JNK	52,55	c-Jun_N-terminal_kinase	27,50	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	IL-1-induced NFkappa B and c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation diverge at IL-1_receptor-associated_kinase -LRB- IRAK -RRB- .
11846804	0	JNK	53,56	c-Jun_N-terminal_kinase	28,51	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Transient activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- activity by ligation of the tetraspan CD53 antigen in different cell types .
11856743	0	JNK	43,46	c-Jun_N-terminal_kinase	18,41	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling pathway is essential during PBOX-6-induced apoptosis in chronic_myelogenous_leukemia -LRB- CML -RRB- cells .
12879014	0	JNK	53,56	c-Jun_N-terminal_kinase	28,51	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Selective activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3 ' - kinase -LRB- PI3K -RRB- pathway is inhibited .
12880208	0	JNK	37,40	c-Jun_N-terminal_kinase	12,35	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of c-Jun_N-terminal_kinase -LRB- JNK -RRB- in Parkinson 's _ disease .
16367930	0	JNK	39,42	c-Jun_N-terminal_kinase	14,37	JNK	c-Jun N-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- signalling in experimentally induced gastric_lesions in rats .
17070508	0	JNK	105,108	c-Jun_N-terminal_kinase	80,103	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	IL-2 / IL-18 prevent the down-modulation of NKG2D by TGF-beta in NK cells via the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
17106880	0	JNK	50,53	c-Jun_N-terminal_kinase	25,48	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Oxidative stress-induced c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation in tendon cells upregulates MMP1 mRNA and protein expression .
17959308	0	JNK	89,92	c-Jun_N-terminal_kinase	64,87	JNK	c-Jun N-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Expression of FasL and its interaction with Fas are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway in 6-OHDA-induced rat model of Parkinson_disease .
18222647	0	JNK	39,42	c-Jun_N-terminal_kinase	14,37	JNK	c-Jun N-terminal kinase	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- by widely used specific p38_MAPK inhibitors SB202190 and SB203580 : a MLK-3-MKK7-dependent mechanism .
18506470	0	JNK	54,57	c-Jun_N-terminal_kinase	29,52	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- in endometrial cells in vivo and in vitro .
19477251	0	JNK	109,112	c-Jun_N-terminal_kinase	84,107	JNK	c-Jun N-terminal kinase	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	1,3-Dinitrobenzene induces apoptosis in TM4 mouse Sertoli cells : Involvement of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- MAPK pathway .
19900593	0	JNK	25,28	c-Jun_N-terminal_kinase	0,23	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling : recent advances and challenges .
20709173	0	JNK	81,84	c-Jun_N-terminal_kinase	56,79	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation by phosphorylation and purification of human c-Jun_N-terminal_kinase -LRB- JNK -RRB- isoforms in milligram amounts .
21162712	0	JNK	28,31	c-Jun_N-terminal_kinase	33,56	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|END_ENTITY	Characterization of a novel JNK -LRB- c-Jun_N-terminal_kinase -RRB- inhibitory peptide .
21277902	0	JNK	133,136	c-Jun_N-terminal_kinase	108,131	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	IDO metabolite produced by EBV-transformed B cells inhibits surface expression of NKG2D in NK cells via the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
22496813	0	JNK	39,42	c-Jun_N-terminal_kinase	14,37	JNK	c-Jun N-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- during mitosis in retinal progenitor cells .
22577133	0	JNK	187,190	c-Jun_N-terminal_kinase	162,185	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Lysophosphatidic_acid induces early growth response-1 -LRB- Egr-1 -RRB- protein expression via protein kinase C - regulated extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation in vascular smooth muscle cells .
23184940	0	JNK	34,37	c-Jun_N-terminal_kinase	9,32	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Blocking c-Jun_N-terminal_kinase -LRB- JNK -RRB- translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo .
23430246	0	JNK	76,79	c-Jun_N-terminal_kinase	51,74	JNK	c-Jun N-terminal kinase	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	b2 adrenergic receptor , protein kinase A -LRB- PKA -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling pathways mediate tau pathology in Alzheimer_disease models .
23597429	0	JNK	99,102	c-Jun_N-terminal_kinase	74,97	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	TNF-a up-regulates cellular_inhibitor_of_apoptosis_protein_2 -LRB- c-IAP2 -RRB- via c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway in nasopharyngeal_carcinoma .
24825906	0	JNK	90,93	c-Jun_N-terminal_kinase	65,88	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation .
8647130	0	JNK	134,137	c-Jun_N-terminal_kinase	109,132	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	signal|appos|START_ENTITY signal|amod|END_ENTITY	Sphingomyelin-derived lipids differentially regulate the extracellular_signal-regulated_kinase_2 -LRB- ERK-2 -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- signal cascades in airway smooth muscle .
9792916	0	JNK	39,42	c-Jun_N-terminal_kinase	14,37	JNK	c-Jun N-terminal kinase	5599	5599	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- by lysophosphatidic_acid in Swiss 3T3 fibroblasts .
18758060	0	JNK	157,160	c-Jun_N-terminal_protein_kinase	124,155	JNK	c-Jun N-terminal protein kinase	5599	5599	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Differential regulation of the antiapoptotic action of B-cell_lymphoma_2 -LRB- Bcl-2 -RRB- and B-cell_lymphoma extra long -LRB- Bcl-xL -RRB- by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 1-involved pathway in neuroglioma cells .
16491125	0	JNK	135,138	c-Jun_NH2-terminal_kinase	108,133	JNK	c-Jun NH2-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun_NH2-terminal_kinase -LRB- JNK -RRB- pathway .
17225125	0	JNK	41,44	c-Jun_NH2-terminal_kinase	14,39	JNK	c-Jun NH2-terminal kinase	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Activation of c-Jun_NH2-terminal_kinase -LRB- JNK -RRB- pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor .
18773087	0	JNK	64,67	c-Jun_amino_terminal_kinase	35,62	JNK	c-Jun amino terminal kinase	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A predominant role for parenchymal c-Jun_amino_terminal_kinase -LRB- JNK -RRB- in the regulation of systemic_insulin_sensitivity .
12149148	0	JNK	121,124	c-Jun_terminal_kinase	126,147	JNK	c-Jun terminal kinase	5599	5599	Gene	Gene	activation|compound|START_ENTITY activation|dep|END_ENTITY	An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small_cell_lung_cancer cells via JNK -LRB- c-Jun_terminal_kinase -RRB- activation .
12719447	0	JNK	72,75	c-Src	42,47	JNK	c-Src	5599	6714	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Selective involvement of p130Cas/Crk/Pyk2 / c-Src in endothelin-1-induced JNK activation .
9930727	0	JNK	57,60	c-fos	14,19	JNK	c-fos	5599	2353	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of c-fos , c-jun , and c-jun_N-terminal_kinase -LRB- JNK -RRB- in a developmental model of induced apoptotic death in neurons of the substantia nigra .
19947601	0	JNK	116,119	c-jun-N-terminal_kinase	91,114	JNK	c-jun-N-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis , biological evaluation , X-ray structure , and pharmacokinetics of aminopyrimidine c-jun-N-terminal_kinase -LRB- JNK -RRB- inhibitors .
12931215	0	JNK	47,50	c-jun-terminal_kinase	24,45	JNK	c-jun-terminal kinase	5599	5599	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Sustained activation of c-jun-terminal_kinase -LRB- JNK -RRB- is closely related to arsenic_trioxide-induced apoptosis in an acute_myeloid_leukemia -LRB- M2 -RRB- - derived cell line , NKM-1 .
10381634	0	JNK	57,60	c-jun_N-terminal_kinase	32,55	JNK	c-jun N-terminal kinase	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Etoposide-induced activation of c-jun_N-terminal_kinase -LRB- JNK -RRB- correlates with drug-induced apoptosis in salivary gland acinar cells .
24332487	0	JNK	73,76	c-jun_N-terminal_kinase	48,71	JNK	c-jun N-terminal kinase	5599	5599	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and SAR of novel isoxazoles as potent c-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitors .
10942386	0	JNK	28,31	cJun	4,8	JNK	cJun	26419(Tax:10090)	16476(Tax:10090)	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	The cJun N-terminal kinase -LRB- JNK -RRB- signaling pathway mediates induction of urokinase-type_plasminogen_activator -LRB- uPA -RRB- by the alkylating agent MNNG .
16294326	0	JNK	70,73	connective_tissue_growth_factor	88,119	JNK	connective tissue growth factor	116554(Tax:10116)	64032(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Microarray and phosphokinase screenings leading to studies on ERK and JNK regulation of connective_tissue_growth_factor expression by angiotensin_II 1a and bradykinin B2 receptors in Rat1 fibroblasts .
10910907	0	JNK	0,3	erythropoietin	29,43	JNK	erythropoietin	5599	2056	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	JNK and p38 are activated by erythropoietin -LRB- EPO -RRB- but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells .
9362525	0	JNK	131,134	extracellular_signal-regulated_kinase	58,95	JNK	extracellular signal-regulated kinase	5599	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA-4 -RRB- interferes with extracellular_signal-regulated_kinase -LRB- ERK -RRB- and Jun_NH2-terminal_kinase -LRB- JNK -RRB- activation , but does not affect phosphorylation of T cell receptor zeta and ZAP70 .
23846687	0	JNK	83,86	interleukin-1a	120,134	JNK	interleukin-1a	5599	3552	Gene	Gene	activation|compound|START_ENTITY activation|nmod|cells cells|amod|END_ENTITY	N-myc_downstream-regulated_gene_1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1a by human gastric_cancer cells .
21181166	0	JNK	89,92	interleukin-34	65,79	JNK	interleukin-34	5599	146433	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Proinflammatory cytokines , IL-1b and TNF-a , induce expression of interleukin-34 mRNA via JNK - and p44/42 MAPK-NF-kB pathway but not p38 pathway in osteoblasts .
14507925	0	JNK	53,56	islet-brain_1	74,87	JNK	islet-brain 1	5599	9479	Gene	Gene	degradation|nmod|START_ENTITY scaffold|nsubj|degradation scaffold|xcomp|END_ENTITY	Calcium - and proteasome-dependent degradation of the JNK scaffold protein islet-brain_1 .
14561487	0	JNK	4,7	islet-brain_1	26,39	JNK	islet-brain 1	116554(Tax:10116)	116457(Tax:10116)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|activity activity|amod|END_ENTITY	The JNK binding domain of islet-brain_1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines .
14561487	0	JNK	62,65	islet-brain_1	26,39	JNK	islet-brain 1	116554(Tax:10116)	116457(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	The JNK binding domain of islet-brain_1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines .
21132267	0	JNK	114,117	lipocalin_2	82,93	JNK	lipocalin 2	5599	3934	Gene	Gene	blockade|nmod|START_ENTITY END_ENTITY|nmod|blockade	Inhibition of the proliferation and invasion of hepatocellular_carcinoma cells by lipocalin_2 through blockade of JNK and PI3K/Akt signaling .
20398340	0	JNK	16,19	mPGES-1	130,137	JNK	mPGES-1	5599	64292(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Signal pathways JNK and NF-kappaB , identified by global gene expression profiling , are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts .
24434654	0	JNK	75,78	mdig	53,57	JNK	mdig	5599	84864	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation .
11257445	0	JNK	143,146	mitogen-activated_protein_kinase_phosphatase-2	32,78	JNK	mitogen-activated protein kinase phosphatase-2	5599	1846	Gene	Gene	translocation|compound|START_ENTITY dependent|nmod|translocation dependent|nsubj|Inactivation Inactivation|nmod|activity activity|nmod|END_ENTITY	Inactivation of JNK activity by mitogen-activated_protein_kinase_phosphatase-2 in EAhy926 endothelial cells is dependent upon agonist-specific JNK translocation to the nucleus .
11257445	0	JNK	16,19	mitogen-activated_protein_kinase_phosphatase-2	32,78	JNK	mitogen-activated protein kinase phosphatase-2	5599	1846	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Inactivation of JNK activity by mitogen-activated_protein_kinase_phosphatase-2 in EAhy926 endothelial cells is dependent upon agonist-specific JNK translocation to the nucleus .
11709198	0	JNK	209,212	p38	170,173	JNK	p38	5599	5594	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Potentiation of cadmium-induced cytotoxicity by sulfur amino_acid deprivation through activation of extracellular_signal-regulated_kinase1 / 2 -LRB- ERK1/2 -RRB- in conjunction with p38 kinase or c-jun_N-terminal_kinase -LRB- JNK -RRB- .
21986805	0	JNK	124,127	p38	119,122	JNK	p38	116554(Tax:10116)	81649(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Mimosine-induced apoptosis in C6_glioma cells requires the release of mitochondria-derived reactive oxygen species and p38 , JNK activation .
10656807	0	JNK	12,15	p53	76,79	JNK	p53	5599	7157	Gene	Gene	Analysis|nmod|START_ENTITY contribution|nsubj|Analysis contribution|nmod|regulation regulation|nmod|stability stability|compound|END_ENTITY	Analysis of JNK , Mdm2 and p14 -LRB- ARF -RRB- contribution to the regulation of mutant p53 stability .
14724588	0	JNK	14,17	p53	54,57	JNK	p53	5599	7157	Gene	Gene	Inhibition|nmod|START_ENTITY reduces|nsubj|Inhibition reduces|dobj|proliferation proliferation|amod|independent independent|nmod|END_ENTITY	Inhibition of JNK reduces G2/M transit independent of p53 , leading to endoreduplication , decreased proliferation , and apoptosis in breast_cancer cells .
15778501	0	JNK	115,118	p53	34,37	JNK	p53	5599	7157	Gene	Gene	links|nsubj|START_ENTITY regulate|parataxis|links regulate|dobj|END_ENTITY	JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix : JNK links FAK and p53 .
17125918	0	JNK	135,138	p53	60,63	JNK	p53	5599	7157	Gene	Gene	signalling|nmod|START_ENTITY requiring|advcl|signalling pathway|acl|requiring pathway|compound|END_ENTITY	Simvastatin induces apoptosis in human breast_cancer cells : p53 and estrogen_receptor independent pathway requiring signalling through JNK .
21763279	0	JNK	118,121	p53	0,3	JNK	p53	5599	7157	Gene	Gene	activation|compound|START_ENTITY suppression|nmod|activation apoptosis|nmod|suppression inhibits|dobj|apoptosis inhibits|nsubj|activation activation|compound|END_ENTITY	p53 activation inhibits ochratoxin_A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation .
22276160	0	JNK	18,21	p53	10,13	JNK	p53	5599	7157	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Targeting p53 via JNK pathway : a novel role of RITA for apoptotic signaling in multiple_myeloma .
22467874	3	JNK	421,424	p53	520,523	p53	JNK	22060(Tax:10090)	44801(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY extent|nmod|activity dependent|nsubj|extent dependent|nmod|p53 p53|nmod|fibroblasts fibroblasts|nmod|loss loss|nmod|END_ENTITY	Likewise , the extent of JNK activity after UV irradiation is dependent on p53 in murine embryonic fibroblasts with loss of p53 resulting in diminished JNK activity .
24366007	0	JNK	47,50	p53	92,95	JNK	p53	5599	7157	Gene	Gene	START_ENTITY|nmod|manner manner|nmod|END_ENTITY	Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53 .
24413150	0	JNK	28,31	p53	41,44	JNK	p53	5599	7157	Gene	Gene	activation|nmod|START_ENTITY converts|nsubj|activation converts|dobj|END_ENTITY	ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis .
26112108	0	JNK	8,11	p53	32,35	JNK	p53	5599	7157	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro .
26388570	0	JNK	8,11	p53	32,35	JNK	p53	5599	7157	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor .
26388570	0	JNK	8,11	p53	32,35	JNK	p53	5599	7157	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor .
26608375	0	JNK	8,11	p53	31,34	JNK	p53	5599	7157	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid_Songorine .
9732264	0	JNK	0,3	p53	12,15	JNK	p53	5599	7157	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|ubiquitination ubiquitination|compound|END_ENTITY	JNK targets p53 ubiquitination and degradation in nonstressed cells .
12135322	0	JNK	48,51	preproET-1	17,27	JNK	preproET-1	5599	1906	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Galpha13 induces preproET-1 gene expression via JNK .
26740179	0	JNK	104,107	pyruvate_dehydrogenase_kinase_4	23,54	JNK	pyruvate dehydrogenase kinase 4	26419(Tax:10090)	27273(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inflammation increases pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- expression via the Jun N-Terminal Kinase -LRB- JNK -RRB- pathway in C2C12 cells .
26126628	0	JNK	111,114	sFRP5	62,67	JNK	sFRP5	116554(Tax:10116)	309377(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
26126628	0	JNK	111,114	secreted_frizzled-related_protein_5	25,60	JNK	secreted frizzled-related protein 5	116554(Tax:10116)	309377(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
24556843	0	JNK	133,136	vascular_peroxidase-1	106,127	JNK	vascular peroxidase-1	5599	7837	Gene	Gene	manner|compound|START_ENTITY END_ENTITY|nmod|manner	Activation of a7_nicotinic_acetylcholine_receptor protects against oxidant stress damage through reducing vascular_peroxidase-1 in a JNK signaling-dependent manner in endothelial cells .
21542902	0	JNK	83,86	visfatin	59,67	JNK	visfatin	5599	10135	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	Tumor_necrosis_factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells .
16238095	0	JNK-1	49,54	PP4	24,27	JNK-1	PP4	5599	5531	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Role of the phosphatase PP4 in the activation of JNK-1 in prostate_carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity .
23523351	0	JNK-1	80,85	TIR-1	74,79	JNK-1	TIR-1	177460(Tax:6239)	175502(Tax:6239)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Forgetting in C. _ elegans is accelerated by neuronal communication via the TIR-1 / JNK-1 pathway .
24865582	0	JNK-1	65,70	c-Jun	71,76	JNK-1	c-Jun	5599	3725	Gene	Gene	ovarian_cancer|nmod|START_ENTITY Upregulation|nmod|ovarian_cancer /|nsubj|Upregulation /|dobj|pathway pathway|amod|END_ENTITY	Upregulation of miR-21 in cisplatin resistant ovarian_cancer via JNK-1 / c-Jun pathway .
25541976	0	JNK-1	77,82	c-Jun	83,88	JNK-1	c-Jun	5599	3725	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Correction : Upregulation of miR-21 in Cisplatin_Resistant_Ovarian_Cancer via JNK-1 / c-Jun Pathway .
11384840	0	JNK-1	41,46	c-Jun_N-terminal_kinase_1	14,39	JNK-1	c-Jun N-terminal kinase 1	5599	5599	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-Jun_N-terminal_kinase_1 -LRB- JNK-1 -RRB- after amino_acid deficiency in HeLa cells .
19385034	0	JNK-binding_protein_1	0,21	TRAF2	61,66	JNK-binding protein 1	TRAF2	23005	7186	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	JNK-binding_protein_1 regulates NF-kappaB activation through TRAF2 and TAK1 .
12783873	0	JNK-interacting_protein_1	0,25	Akt1	35,39	JNK-interacting protein 1	Akt1	9479	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activation activation|amod|END_ENTITY	JNK-interacting_protein_1 promotes Akt1 activation .
19616077	0	JNK-interacting_protein_1	12,37	islet_brain_1	38,51	JNK-interacting protein 1	islet brain 1	9479	9479	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of the JNK-interacting_protein_1 / islet_brain_1 in cell degeneration in Alzheimer_disease and diabetes .
12600107	0	JNK/SAPK	16,24	ICAM-1	56,62	JNK/SAPK	ICAM-1	5599;5601	3383	Gene	Gene	activity|compound|START_ENTITY Correlation|nmod|activity Correlation|nmod|END_ENTITY	-LSB- Correlation of JNK/SAPK activity and the production of ICAM-1 on renal mesangial cells in vitro -RSB- .
15908180	0	JNK/SAPK	26,34	TNF-alpha	46,55	JNK/SAPK	TNF-alpha	5599;5601	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma : apoptosis of pancreatic beta-cells via the p53 and ROS pathway .
9343388	0	JNK/SAPK	226,234	TNF-alpha	144,153	JNK/SAPK	TNF-alpha	5599;5601	7124	Gene	Gene	blocking|dobj|START_ENTITY inhibit|advcl|blocking required|ccomp|inhibit required|nmod|stimulation stimulation|nmod|translation translation|appos|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
9343388	0	JNK/SAPK	226,234	TNF-alpha	192,201	JNK/SAPK	TNF-alpha	5599;5601	7124	Gene	Gene	blocking|dobj|START_ENTITY inhibit|advcl|blocking inhibit|dobj|translation translation|amod|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
9343388	0	JNK/SAPK	55,63	TNF-alpha	144,153	JNK/SAPK	TNF-alpha	5599;5601	7124	Gene	Gene	kinase|appos|START_ENTITY required|nsubjpass|kinase required|nmod|stimulation stimulation|nmod|translation translation|appos|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
9343388	0	JNK/SAPK	55,63	TNF-alpha	192,201	JNK/SAPK	TNF-alpha	5599;5601	7124	Gene	Gene	kinase|appos|START_ENTITY required|nsubjpass|kinase required|ccomp|inhibit inhibit|dobj|translation translation|amod|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
17065197	0	JNK1	0,4	COX-2	36,41	JNK1	COX-2	5599	5743	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	JNK1 , but not JNK2 , is required for COX-2 induction by nickel compounds .
21856198	0	JNK1	0,4	Cdt1	24,28	JNK1	Cdt1	5599	81620	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress .
22778214	0	JNK1	94,98	FGF21	106,111	JNK1	FGF21	26419(Tax:10090)	56636(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	TNF-a represses b-Klotho expression and impairs FGF21 action in adipose cells : involvement of JNK1 in the FGF21 pathway .
20068160	0	JNK1	0,4	HIF-1alpha	26,36	JNK1	HIF-1alpha	5599	3091	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70 .
8830657	0	JNK1	47,51	Interleukin_1	0,13	JNK1	Interleukin 1	5599	3552	Gene	Gene	kinases|dobj|START_ENTITY activates|ccomp|kinases activates|nsubj|END_ENTITY	Interleukin_1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase -LRB- ERK -RRB- in human glomerular mesangial cells .
15141161	0	JNK1	49,53	JIP1	81,85	JNK1	JIP1	5599	9479	Gene	Gene	inhibition|nmod|START_ENTITY basis|nmod|inhibition basis|nmod|END_ENTITY	Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 .
24989893	0	JNK1	86,90	Mark4	0,5	JNK1	Mark4	26419(Tax:10090)	232944(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways .
20150185	0	JNK1	23,27	Mixed_lineage_kinase-3	0,22	JNK1	Mixed lineage kinase-3	5599	4296	Gene	Gene	axis|compound|START_ENTITY promotes|nsubj|axis END_ENTITY|parataxis|promotes	Mixed_lineage_kinase-3 / JNK1 axis promotes migration of human gastric_cancer cells following gastrin stimulation .
23593480	0	JNK1	35,39	Noxa	27,31	JNK1	Noxa	26419(Tax:10090)	58801(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors .
16618812	0	JNK1	0,4	SCG10	24,29	JNK1	SCG10	5599	11075	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic_length .
17074809	0	JNK1	62,66	TBP	0,3	JNK1	TBP	5599	6908	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TBP is differentially regulated by c-Jun N-terminal kinase 1 -LRB- JNK1 -RRB- and JNK2 through Elk-1 , controlling c-Jun expression and cell proliferation .
20552320	0	JNK1	19,23	TNF-alpha	40,49	JNK1	TNF-alpha	5599	7124	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Distinct roles for JNK1 and JNK3 during TNF-alpha - or etoposide-induced apoptosis in HeLa cells .
24388750	0	JNK1	69,73	WDR62	32,37	JNK1	WDR62	5599	284403	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex .
12040039	0	JNK1	139,143	c-Jun	89,94	JNK1	c-Jun	26419(Tax:10090)	16476(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY presence|nmod|activity activated|nmod|presence activated|xcomp|mediating mediating|dobj|activation activation|amod|END_ENTITY	c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 2/3 is specifically activated by stress , mediating c-Jun activation , in the presence of constitutive JNK1 activity in cerebellar neurons .
12376563	0	JNK1	0,4	c-Jun	47,52	JNK1	c-Jun	26419(Tax:10090)	16476(Tax:10090)	Gene	Gene	modulates|compound|START_ENTITY osteoclastogenesis|nsubj|modulates osteoclastogenesis|nmod|phosphorylation-dependent phosphorylation-dependent|amod|END_ENTITY	JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and - independent mechanisms .
15572687	0	JNK1	35,39	c-Jun	109,114	JNK1	c-Jun	26419(Tax:10090)	16476(Tax:10090)	Gene	Gene	1|appos|START_ENTITY essential|nsubj|1 essential|nmod|activation activation|amod|END_ENTITY	c-Jun_N-terminal_protein_kinase 1 -LRB- JNK1 -RRB- , but not JNK2 , is essential for tumor_necrosis_factor_alpha-induced c-Jun kinase activation and apoptosis .
21604193	0	JNK1	77,81	c-Jun	14,19	JNK1	c-Jun	5599	3725	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1 .
7890669	0	JNK1	130,134	c-Jun	116,121	JNK1	c-Jun	26419(Tax:10090)	16476(Tax:10090)	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase , JNK1 .
11077051	0	JNK1	41,45	c-Jun_N-terminal_kinase_1	14,39	JNK1	c-Jun N-terminal kinase 1	5599	5599	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells .
16157589	0	JNK1	75,79	c-Jun_N-terminal_kinase_1	48,73	JNK1	c-Jun N-terminal kinase 1	5599	5599	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- inhibits c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation by transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 -LRB- TAK1 -RRB- .
21540183	0	JNK1	91,95	c-Jun_N-terminal_kinase_1	64,89	JNK1	c-Jun N-terminal kinase 1	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- protein degradation in response to persistent c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation contributes to hepatic_steatosis in obesity .
8557665	0	JNK1	52,56	c-Jun_N-terminal_kinase_1	25,50	JNK1	c-Jun N-terminal kinase 1	5599	5599	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Persistent activation of c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- in gamma radiation-induced apoptosis .
19339050	0	JNK1	81,85	c-Jun_N-terminal_kinase_2	0,25	JNK1	c-Jun N-terminal kinase 2	5599	5601	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	c-Jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- antagonizes the signaling of differentiation by JNK1 in human myeloid_leukemia cells resistant to vitamin_D .
10487526	0	JNK1	134,138	c-Jun_NH2-terminal_kinase_1	105,132	JNK1	c-Jun NH2-terminal kinase 1	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Induction of apoptosis by dexrazoxane -LRB- ICRF-187 -RRB- through caspases in the absence of c-jun expression and c-Jun_NH2-terminal_kinase_1 -LRB- JNK1 -RRB- activation in VM-26-resistant CEM cells .
17061159	0	JNK1	45,49	c-Jun_NH2-terminal_kinase_1	16,43	JNK1	c-Jun NH2-terminal kinase 1	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Crucial role of c-Jun_NH2-terminal_kinase_1 -LRB- JNK1 -RRB- in cold-restraint stress-induced gastric_lesions in mice .
12534344	0	JNK1	38,42	p53	113,116	JNK1	p53	5599	7157	Gene	Gene	START_ENTITY|nmod|stabilization stabilization|nmod|END_ENTITY	A role for c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- , but not JNK2 , in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons .
15778501	0	JNK1	0,4	p53	34,37	JNK1	p53	5599	7157	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix : JNK links FAK and p53 .
20018857	0	JNK1	131,135	phosphatidylinositol_3-kinase	65,94	JNK1	phosphatidylinositol 3-kinase	5599	5293	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol_3-kinase - and focal adhesion kinase-mediated JNK1 activation .
16157589	0	JNK1	75,79	transforming_growth_factor_beta1	95,127	JNK1	transforming growth factor beta1	5599	7040	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- inhibits c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation by transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 -LRB- TAK1 -RRB- .
15797868	0	JNK1/2	115,121	Akt1	165,169	JNK1/2	Akt1	5599;5601	207	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of preconditioning ischemia on ischemic_brain_injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation .
20231852	0	JNK1/2	16,22	CD150	0,5	JNK1/2	CD150	5599;5601	6504	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	CD150 regulates JNK1/2 activation in normal and Hodgkin 's _ lymphoma B cells .
22166618	0	JNK2	146,150	c-jun_N-terminal_kinase_2	119,144	JNK2	c-jun N-terminal kinase 2	26420(Tax:10090)	26420(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- pathway .
17680991	0	JNK3	25,29	Cone_arrestin	0,13	JNK3	Cone arrestin	5602	407	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Cone_arrestin binding to JNK3 and Mdm2 : conformational preference and localization of interaction sites .
12436199	0	JNK3	100,104	Fas-associated_phosphatase-1	30,58	JNK3	Fas-associated phosphatase-1	5602	5783	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Head-to-head juxtaposition of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- and c-Jun_NH2-terminal_kinase_3 -LRB- JNK3 -RRB- genes : genomic structure and seven polymorphisms of the FAP-1 gene .
15944381	0	JNK3	107,111	beta-amyloid_precursor_protein	32,62	JNK3	beta-amyloid precursor protein	5602	351	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|regulation regulation|nmod|END_ENTITY	Physiological regulation of the beta-amyloid_precursor_protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation .
16989998	0	JNK3	173,177	c-Jun_N-terminal_kinase-3	146,171	JNK3	c-Jun N-terminal kinase-3	5602	5602	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Three-dimensional quantitative structure-activity relationship -LRB- 3 D-QSAR -RRB- and docking studies on -LRB- benzothiazole-2-yl -RRB- acetonitrile derivatives as c-Jun_N-terminal_kinase-3 -LRB- JNK3 -RRB- inhibitors .
20219637	0	JNK3	123,127	c-Jun_N-terminal_kinase_3	96,121	JNK3	c-Jun N-terminal kinase 3	5602	5602	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Neuroprotection of ethanol against ischemia/reperfusion-induced brain_injury through decreasing c-Jun_N-terminal_kinase_3 -LRB- JNK3 -RRB- activation by enhancing GABA release .
11322657	0	JNK3	32,36	c-Jun_NH2-terminal_kinase3	4,30	JNK3	c-Jun NH2-terminal kinase3	5602	5602	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The c-Jun_NH2-terminal_kinase3 -LRB- JNK3 -RRB- gene : genomic structure , chromosomal assignment , and loss of expression in brain_tumors .
19525941	0	JNK3	67,71	huntingtin	11,21	JNK3	huntingtin	26414(Tax:10090)	15194(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin .
10715136	0	JNK3_alpha	108,118	MKK4	41,45	JNK3 alpha	MKK4	5602	6416	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|dep|characterization	Activation of JNK3_alpha 1 requires both MKK4 and MKK7 : kinetic characterization of in vitro phosphorylated JNK3_alpha 1 .
10715136	0	JNK3_alpha	14,24	MKK4	41,45	JNK3 alpha	MKK4	5602	6416	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of JNK3_alpha 1 requires both MKK4 and MKK7 : kinetic characterization of in vitro phosphorylated JNK3_alpha 1 .
26468278	0	JNK_associated_leucine_zipper_protein	0,37	Forkhead_box_protein_K1	148,171	JNK associated leucine zipper protein	Forkhead box protein K1	9043	221937	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	JNK_associated_leucine_zipper_protein functions as a docking platform for Polo_like_kinase_1 and regulation of the associating transcription factor Forkhead_box_protein_K1 .
16735438	0	JPO2	79,83	p75	29,32	JPO2	p75	55536	11168	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin .
8345107	0	JUN	0,3	FOS	5,8	JUN	FOS	24516(Tax:10116)	314322(Tax:10116)	Gene	Gene	transcription|advmod|START_ENTITY transcription|nsubj|END_ENTITY	JUN , FOS , KROX , and CREB transcription factor proteins in the rat cortex : basal expression and induction by spreading depression and epileptic_seizures .
19219074	0	JUN	58,61	GLI	75,78	JUN	GLI	3725	2735	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes .
24127737	0	JUN	19,22	HSF1	74,78	JUN	HSF1	3725	3297	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The proto-oncogene JUN is a target of the heat shock transcription factor HSF1 .
18755854	0	JUN	12,15	STAR	52,56	JUN	STAR	16476(Tax:10090)	20845(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	The role of JUN in the regulation of PRKCC-mediated STAR expression and steroidogenesis in mouse Leydig cells .
17690253	0	JUNB	66,70	ERK1/2	89,95	JUNB	ERK1/2	3726	5595;5594	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	The oncoprotein NPM-ALK of anaplastic_large-cell_lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling .
17651017	0	JUND	41,45	Stat2	21,26	JUND	Stat2	3727	6773	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Interferon-inducible Stat2 activation of JUND and CLDN4 : mediators of IFN responses .
24157826	0	JWA	15,18	ING4	0,4	JWA	ING4	10550	51147	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	ING4 regulates JWA in angiogenesis and their prognostic value in melanoma patients .
19208635	0	JWA	0,3	XRCC1	14,19	JWA	XRCC1	10550	7515	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks .
15911144	0	Jab1	59,63	Brn-2	38,43	Jab1	Brn-2	10987	5454	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The neuronal POU transcription factor Brn-2 interacts with Jab1 , a gene involved in the onset of neurodegenerative_diseases .
18534028	0	Jab1	0,4	EGFR	20,24	Jab1	EGFR	10987	1956	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Jab1 is a target of EGFR signaling in ERalpha-negative breast_cancer .
20978819	0	Jab1	21,25	Fank1	0,5	Jab1	Fank1	10987	92565	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway .
11707426	0	Jab1	0,4	HIF-1alpha	29,39	Jab1	HIF-1alpha	10987	3091	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Jab1 interacts directly with HIF-1alpha and regulates its stability .
22609399	0	Jab1	0,4	brain-specific_kinase_2	20,43	Jab1	brain-specific kinase 2	10987	9024	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Jab1 interacts with brain-specific_kinase_2 -LRB- BRSK2 -RRB- and promotes its degradation in the ubiquitin-proteasome pathway .
11751512	0	Jab1	0,4	kip1	61,65	Jab1	kip1	10987	1027	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|nmod|END_ENTITY	Jab1 expression is associated with inverse expression of p27 -LRB- kip1 -RRB- and poor prognosis in epithelial_ovarian_tumors .
11751512	0	Jab1	0,4	p27	57,60	Jab1	p27	10987	3429	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|nmod|kip1 kip1|amod|END_ENTITY	Jab1 expression is associated with inverse expression of p27 -LRB- kip1 -RRB- and poor prognosis in epithelial_ovarian_tumors .
16300740	0	Jab1	42,46	p27	78,81	Jab1	p27	10987	10671	Gene	Gene	p8|nmod|START_ENTITY Interaction|nmod|p8 required|nsubjpass|Interaction required|nmod|translocation translocation|nummod|END_ENTITY	Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation .
24170542	0	Jab1	90,94	p27	32,35	Jab1	p27	10987	10534	Gene	Gene	down-regulation|nmod|START_ENTITY accumulation|nmod|down-regulation accumulation|amod|END_ENTITY	Adhesion to fibronectin induces p27 -LRB- Kip1 -RRB- nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance -LRB- CAM-DR -RRB- in RPMI 8,226 cells .
24344238	0	Jab1	0,4	p27	69,72	Jab1	p27	26754(Tax:10090)	12576(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Jab1 regulates Schwann cell proliferation and axonal sorting through p27 .
24949832	0	Jab1	86,90	p27	60,63	Jab1	p27	3725	10671	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1 .
18684714	0	Jade-1	8,14	HBO1	54,58	Jade-1	HBO1	79960	11143	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of Jade-1 in the histone acetyltransferase -LRB- HAT -RRB- HBO1 complex .
21685392	0	Jagged-1	61,69	miR-143	4,11	Jagged-1	miR-143	182	406935	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	The miR-143 / 145 cluster is a novel transcriptional target of Jagged-1 / Notch signaling in vascular smooth muscle cells .
18449946	0	Jagged-1_and_Delta-1	47,67	Notch-1	14,21	Jagged-1 and Delta-1	Notch-1	29146;84010	25496(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of Notch-1 receptor and its ligands Jagged-1_and_Delta-1 in amoeboid microglia in postnatal rat brain and murine_BV-2 cells .
10473135	0	Jagged1	35,42	Delta1	14,20	Jagged1	Delta1	16449(Tax:10090)	13388(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Delta1 and Serrate1 -LRB- Jagged1 -RRB- in the mouse inner ear .
26276215	0	Jagged1	26,33	Fe65	0,4	Jagged1	Fe65	182	322	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1 .
26276215	0	Jagged1	58,65	Fe65	0,4	Jagged1	Fe65	182	322	Gene	Gene	stability|amod|START_ENTITY decreasing|dobj|stability signaling|advcl|decreasing Jagged1|acl|signaling regulates|dobj|Jagged1 regulates|nsubj|END_ENTITY	Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1 .
14743446	0	Jagged1	12,19	Jagged2	21,28	Jagged1	Jagged2	29146(Tax:10116)	29147(Tax:10116)	Gene	Gene	1|amod|START_ENTITY 1|amod|END_ENTITY	Patterns of Jagged1 , Jagged2 , Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells .
15788413	0	Jagged1	55,62	MAGP-2	33,39	Jagged1	MAGP-2	182	8076	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface .
10934472	0	Jagged1	32,39	Notch1	70,76	Jagged1	Notch1	182	4851	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 .
26249804	0	Jagged1	0,7	Notch1	52,58	Jagged1	Notch1	16449(Tax:10090)	18128(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Jagged1 intracellular domain-mediated inhibition of Notch1 signaling regulates cardiac homeostasis in the postnatal heart .
26249804	0	Jagged1	0,7	Notch1	52,58	Jagged1	Notch1	16449(Tax:10090)	18128(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Jagged1 intracellular domain-mediated inhibition of Notch1 signaling regulates cardiac homeostasis in the postnatal heart .
20169621	0	Jagged1	17,24	TGFbeta1	0,8	Jagged1	TGFbeta1	182	7040	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation .
20727876	0	Jagged1	0,7	Twist1	32,38	Jagged1	Twist1	182	7291	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells .
26751719	0	Jagged1	0,7	osteoprotegerin	17,32	Jagged1	osteoprotegerin	182	4982	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Jagged1 inhibits osteoprotegerin expression by human periodontal ligament cells .
26537340	0	Jagged1	8,15	renin	19,24	Jagged1	renin	182	5972	Gene	Gene	START_ENTITY|nmod|progenitors progenitors|compound|END_ENTITY	Loss of Jagged1 in renin progenitors leads to focal kidney_fibrosis .
14743446	0	Jagged2	21,28	Jagged1	12,19	Jagged2	Jagged1	29147(Tax:10116)	29146(Tax:10116)	Gene	Gene	1|amod|START_ENTITY 1|amod|END_ENTITY	Patterns of Jagged1 , Jagged2 , Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells .
16245338	0	Jagged2	23,30	Notch1	0,6	Jagged2	Notch1	3714	4851	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud .
9315665	0	Jagged2	54,61	Notch1	96,102	Jagged2	Notch1	3714	4851	Gene	Gene	cDNA|nmod|START_ENTITY analysis|nmod|cDNA analysis|appos|gene gene|acl|encoding encoding|dobj|ligand ligand|nmod|receptor receptor|amod|END_ENTITY	Isolation and functional analysis of a cDNA for human Jagged2 , a gene encoding a ligand for the Notch1 receptor .
26940787	0	Jagged_1	70,78	Notch_1	61,68	Jagged 1	Notch 1	16449(Tax:10090)	18128(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	DHA Suppresses Primary Macrophage Inflammatory Responses via Notch_1 / Jagged_1 Signaling .
12130510	0	Jak1	54,58	Akt	26,29	Jak1	Akt	3716	207	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Functional involvement of Akt signaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells .
9794795	0	Jak1	141,145	SHP2	47,51	Jak1	SHP2	3716	5781	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression .
12370803	0	Jak2	0,4	Bcr-Abl	39,46	Jak2	Bcr-Abl	3717	25	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Jak2 is involved in c-Myc induction by Bcr-Abl .
18682290	0	Jak2	23,27	Epo	80,83	Jak2	Epo	3717	2056	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway .
9657743	0	Jak2	51,55	Erythropoietin	0,14	Jak2	Erythropoietin	3717	2056	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces tyrosine phosphorylation of Jak2 , STAT5A , and STAT5B in primary cultured human erythroid precursors .
10551884	0	Jak2	23,27	Fyn	87,90	Jak2	Fyn	3717	2534	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	A catalytically active Jak2 is required for the angiotensin_II-dependent activation of Fyn .
9440544	0	Jak2	108,112	Granulocyte-macrophage_colony-stimulating_factor	0,48	Jak2	Granulocyte-macrophage colony-stimulating factor	3717	1437	Gene	Gene	kinase|amod|START_ENTITY activate|nmod|kinase activate|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils .
15354294	0	Jak2	68,72	Janus_kinase_2	52,66	Jak2	Janus kinase 2	16452(Tax:10090)	16452(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Generation of a conditional knockout allele for the Janus_kinase_2 -LRB- Jak2 -RRB- gene in mice .
17519522	0	Jak2	136,140	Janus_kinase_2	120,134	Jak2	Janus kinase 2	24514(Tax:10116)	24514(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance -LRB- HAA -RRB- rats may be mediated through Janus_kinase_2 -LRB- Jak2 -RRB- activity .
21457752	0	Jak2	18,22	Prolactin	0,9	Jak2	Prolactin	3717	5617	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Prolactin induces Jak2 phosphorylation of RUSHY195 .
23747947	0	Jak2	8,12	Raf-1	57,62	Jak2	Raf-1	16452(Tax:10090)	110157(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY impairs|nsubj|Loss impairs|nmod|END_ENTITY	Loss of Jak2 impairs endothelial function by attenuating Raf-1 / MEK1/Sp -1 signaling along with altered eNOS activities .
11278738	0	Jak2	17,21	Rantes	0,6	Jak2	Rantes	3717	6352	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells .
12952963	0	Jak2	53,57	Receptor_activator_of_NF-kappaB_ligand	0,38	Jak2	Receptor activator of NF-kappaB ligand	16452(Tax:10090)	21943(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Receptor_activator_of_NF-kappaB_ligand induction via Jak2 and Stat5a in mammary epithelial cells .
10772872	0	Jak2	71,75	SH2-Containing_protein_tyrosine_phosphatase-1	0,45	Jak2	SH2-Containing protein tyrosine phosphatase-1	3717	5777	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	SH2-Containing_protein_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- association with Jak2 in UT-7 / Epo cells .
10772872	0	Jak2	71,75	SHP-1	47,52	Jak2	SHP-1	3717	5777	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	SH2-Containing_protein_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- association with Jak2 in UT-7 / Epo cells .
20603212	0	Jak2	73,77	STAT3	34,39	Jak2	STAT3	3717	6774	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression IL-6-induced|nmod|regulation IL-6-induced|dobj|activation activation|compound|END_ENTITY	TGF-beta1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells .
26575024	0	Jak2	24,28	STAT5	74,79	Jak2	STAT5	16452(Tax:10090)	20850(Tax:10090)	Gene	Gene	has|nsubj|START_ENTITY has|dobj|effects effects|nmod|END_ENTITY	Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic_cancer .
19034877	0	Jak2	10,14	Stat1	36,41	Jak2	Stat1	3717	6772	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery .
19118011	0	Jak2	51,55	Stat3	28,33	Jak2	Stat3	16452(Tax:10090)	20848(Tax:10090)	Gene	Gene	mutations|amod|START_ENTITY Independently|nmod|mutations Independently|compound|END_ENTITY	Consistent up-regulation of Stat3 Independently of Jak2 mutations in a new murine model of essential_thrombocythemia .
8702638	0	Jak2	36,40	Stat5	108,113	Jak2	Stat5	3717	6776	Gene	Gene	tyrosine|nsubj|START_ENTITY tyrosine|ccomp|induces induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	An epidermal_growth_factor_receptor / Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells .
9602424	0	Jak2	39,43	Stat5	25,30	Jak2	Stat5	24514(Tax:10116)	24918(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY activates|nmod|kinase activates|dobj|END_ENTITY	Angiotensin_II activates Stat5 through Jak2 kinase in cardiac myocytes .
22090359	0	Jak2	43,47	c-Src	77,82	Jak2	c-Src	3717	6714	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous_carcinoma .
8034573	0	Jak2	76,80	erythropoietin	32,46	Jak2	erythropoietin	16452(Tax:10090)	13856(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY nonessential|nmod|activation nonessential|nsubj|subdomain subdomain|nmod|receptor receptor|compound|END_ENTITY	The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells .
16982687	0	Jak2	62,66	erythropoietin_receptor	19,42	Jak2	erythropoietin receptor	3717	2057	Gene	Gene	binding/activation|amod|START_ENTITY sufficient|nmod|binding/activation sufficient|nsubj|domains domains|nmod|END_ENTITY	Two domains of the erythropoietin_receptor are sufficient for Jak2 binding/activation and function .
18160720	0	Jak2	0,4	erythropoietin_receptor	38,61	Jak2	erythropoietin receptor	3717	2057	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Jak2 FERM domain interaction with the erythropoietin_receptor regulates Jak2 kinase activity .
18160720	0	Jak2	72,76	erythropoietin_receptor	38,61	Jak2	erythropoietin receptor	3717	2057	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|interaction interaction|nmod|END_ENTITY	Jak2 FERM domain interaction with the erythropoietin_receptor regulates Jak2 kinase activity .
9923445	0	Jak2	124,128	erythropoietin_receptor	8,31	Jak2	erythropoietin receptor	3717	2057	Gene	Gene	rates|nmod|START_ENTITY deregulation|nmod|rates associated|nmod|deregulation associated|nsubjpass|mutant mutant|compound|END_ENTITY	A human erythropoietin_receptor gene mutant causing familial_erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation .
9464845	0	Jak2	94,98	granulocyte-macrophage_colony-stimulating_factor	26,74	Jak2	granulocyte-macrophage colony-stimulating factor	3717	1437	Gene	Gene	kinase|amod|START_ENTITY transduced|nmod|kinase transduced|nsubjpass|signals signals|nmod|END_ENTITY	Anti-apoptotic signals of granulocyte-macrophage_colony-stimulating_factor are transduced via Jak2 tyrosine kinase in eosinophils .
7537736	0	Jak2	31,35	prolactin_receptor	55,73	Jak2	prolactin receptor	3717	5618	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Proline-rich sequence-mediated Jak2 association to the prolactin_receptor is required but not sufficient for signal transduction .
7534285	0	Jak2	73,77	thrombopoietin	18,32	Jak2	thrombopoietin	16452(Tax:10090)	21832(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	The c-Mpl_ligand -LRB- thrombopoietin -RRB- stimulates tyrosine phosphorylation of Jak2 , Shc , and c-Mpl .
11134353	0	Jak3	0,4	Bax	27,30	Jak3	Bax	16453(Tax:10090)	12028(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development .
9133417	0	Jak3	0,4	CD40	24,28	Jak3	CD40	3718	958	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells .
16096332	0	Jak3	14,18	Jak3	78,82	Jak3	Jak3	3718	3718	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of Jak3 , STAT1 , STAT4 , and STAT6 in inflammatory_arthritis : unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid_arthritis .
16096332	0	Jak3	78,82	Jak3	14,18	Jak3	Jak3	3718	3718	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of Jak3 , STAT1 , STAT4 , and STAT6 in inflammatory_arthritis : unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid_arthritis .
10733938	0	Jak3	30,34	MAJN	16,20	Jak3	MAJN	3718	9220	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival .
26866290	0	Jam-a	0,5	cxcr4	129,134	Jam-a	cxcr4	50848	7852	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Jam-a is highly expressed on human hematopoietic repopulating cells and associates with the key hematopoietic chemokine receptor cxcr4 .
22622019	0	Janus-activated_kinase-2	14,38	JAK2	40,44	Janus-activated kinase-2	JAK2	3717	3717	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of Janus-activated_kinase-2 -LRB- JAK2 -RRB- by diindolylmethane in ovarian_cancer in vitro and in vivo .
18829531	0	Janus-activated_kinase_2	45,69	cyclophilin_A	17,30	Janus-activated kinase 2	cyclophilin A	3717	5478	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Prolyl isomerase cyclophilin_A regulation of Janus-activated_kinase_2 and the progression of human breast_cancer .
7796812	0	Janus_kinase	27,39	JAK	41,44	Janus kinase	JAK	32080(Tax:7227)	32080(Tax:7227)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of a Drosophila Janus_kinase -LRB- JAK -RRB- causes hematopoietic_neoplasia and developmental defects .
17204555	0	Janus_kinase-2	79,93	SH2B1	48,53	Janus kinase-2	SH2B1	3717	25970	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Identification of SH2B2beta as an inhibitor for SH2B1 - and SH2B2alpha-promoted Janus_kinase-2 activation and insulin signaling .
16939498	0	Janus_kinase-3	34,48	ALK	168,171	Janus kinase-3	ALK	3718	238	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	JSI-124 -LRB- cucurbitacin_I -RRB- inhibits Janus_kinase-3 / signal_transducer_and_activator_of_transcription-3 signalling , downregulates nucleophosmin-anaplastic_lymphoma kinase -LRB- ALK -RRB- , and induces apoptosis in ALK-positive_anaplastic_large_cell_lymphoma cells .
15368094	0	Janus_kinase-3	0,14	JAK3	16,20	Janus kinase-3	JAK3	3718	3718	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Janus_kinase-3 -LRB- JAK3 -RRB- inhibition : a novel immunosuppressive option for allogeneic transplantation .
11786531	0	Janus_kinase_1	14,28	oncostatin_M_receptor	50,71	Janus kinase 1	oncostatin M receptor	3716	9180	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Novel role of Janus_kinase_1 in the regulation of oncostatin_M_receptor surface expression .
14668333	0	Janus_kinase_2	0,14	ABCA1	62,67	Janus kinase 2	ABCA1	3717	19	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Janus_kinase_2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol .
16210729	0	Janus_kinase_2	0,14	ABCA1	113,118	Janus kinase 2	ABCA1	3717	19	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Janus_kinase_2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1 .
21813872	0	Janus_kinase_2	24,38	Angiotensin_II	0,14	Janus kinase 2	Angiotensin II	24514(Tax:10116)	24179(Tax:10116)	Gene	Gene	utilizes|dobj|START_ENTITY utilizes|nsubj|END_ENTITY	Angiotensin_II utilizes Janus_kinase_2 in hypertension , but not in the physiological control of blood pressure , during low-salt intake .
21183952	0	Janus_kinase_2	0,14	Bcr-Abl	25,32	Janus kinase 2	Bcr-Abl	3717	25	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Janus_kinase_2 regulates Bcr-Abl signaling in chronic_myeloid_leukemia .
17133423	0	Janus_kinase_2	17,31	JAK2	33,37	Janus kinase 2	JAK2	3717	3717	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Clearance of the Janus_kinase_2 -LRB- JAK2 -RRB- V617F mutation after allogeneic stem cell transplantation in a patient with myelofibrosis with myeloid_metaplasia .
19215672	0	Janus_kinase_2	23,37	JAK2	39,43	Janus kinase 2	JAK2	3717	3717	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Quantitative assay for Janus_kinase_2 -LRB- JAK2 -RRB- mutation in Chinese patients with chronic_myeloproliferative_disorders .
20359349	0	Janus_kinase_2	65,79	JAK2	81,85	Janus kinase 2	JAK2	3717	3717	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Quantitative assay for the detection of the V617F variant in the Janus_kinase_2 -LRB- JAK2 -RRB- gene using the Luminex xMAP technology .
21477644	0	Janus_kinase_2	12,26	JAK2	28,32	Janus kinase 2	JAK2	3717	3717	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	The role of Janus_kinase_2 -LRB- JAK2 -RRB- activation in pneumococcal EstA protein-induced inflammatory response in RAW 264.7 macrophages .
15354294	0	Janus_kinase_2	52,66	Jak2	68,72	Janus kinase 2	Jak2	16452(Tax:10090)	16452(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Generation of a conditional knockout allele for the Janus_kinase_2 -LRB- Jak2 -RRB- gene in mice .
17519522	0	Janus_kinase_2	120,134	Jak2	136,140	Janus kinase 2	Jak2	24514(Tax:10116)	24514(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance -LRB- HAA -RRB- rats may be mediated through Janus_kinase_2 -LRB- Jak2 -RRB- activity .
11818507	0	Janus_kinase_2	39,53	PKCdelta	26,34	Janus kinase 2	PKCdelta	3717	5580	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Requirement of Ca -LRB- 2 + -RRB- and PKCdelta for Janus_kinase_2 activation by angiotensin_II : involvement of PYK2 .
18653779	0	Janus_kinase_2	48,62	Prolactin	0,9	Janus kinase 2	Prolactin	16452(Tax:10090)	19109(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY signaling|dobj|interact END_ENTITY|acl|signaling	Prolactin and ErbB4/HER4 signaling interact via Janus_kinase_2 to induce mammary epithelial cell gene expression differentiation .
22392353	0	Janus_kinase_2	52,66	Prolactin	0,9	Janus kinase 2	Prolactin	3717	5617	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Prolactin promotes hepatocellular_carcinoma through Janus_kinase_2 .
11818507	0	Janus_kinase_2	39,53	angiotensin_II	68,82	Janus kinase 2	angiotensin II	3717	183	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Requirement of Ca -LRB- 2 + -RRB- and PKCdelta for Janus_kinase_2 activation by angiotensin_II : involvement of PYK2 .
9731195	0	Janus_kinase_2	0,14	angiotensin_II	101,115	Janus kinase 2	angiotensin II	3717	183	Gene	Gene	active|nsubj|START_ENTITY active|nmod|END_ENTITY	Janus_kinase_2 -LRB- Jak2 -RRB- must be catalytically active to associate with the AT1 receptor in response to angiotensin_II .
11042169	0	Janus_kinase_2	104,118	phosphatidylinositol_3-kinase_gamma	67,102	Janus kinase 2	phosphatidylinositol 3-kinase gamma	3717	5294	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol_3-kinase_gamma / Janus_kinase_2 / MEK-1-dependent pathway .
14500680	0	Janus_kinase_2	0,14	platelet-activating_factor_receptor	33,68	Janus kinase 2	platelet-activating factor receptor	3717	5724	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Janus_kinase_2 activation by the platelet-activating_factor_receptor -LRB- PAFR -RRB- : roles of Tyk2 and PAFR C terminus .
17519522	0	Janus_kinase_2	120,134	prolactin	18,27	Janus kinase 2	prolactin	24514(Tax:10116)	24683(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY mediated|nmod|activity mediated|nsubjpass|effects effects|nmod|rats rats|amod|END_ENTITY	Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance -LRB- HAA -RRB- rats may be mediated through Janus_kinase_2 -LRB- Jak2 -RRB- activity .
25762693	0	Janus_kinase_3	33,47	JAK3	49,53	Janus kinase 3	JAK3	3718	3718	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	VX-509 is a potent and selective Janus_kinase_3 -LRB- JAK3 -RRB- inhibitor that attenuates inflammation in animal models of autoimmune_disease .
24795043	0	Janus_kinase_3	30,44	Shc	16,19	Janus kinase 3	Shc	3718	6464	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Adapter protein Shc regulates Janus_kinase_3 phosphorylation .
16308103	0	Janus_kinase_3	27,41	matrix_metalloproteinase_13	50,77	Janus kinase 3	matrix metalloproteinase 13	16453(Tax:10090)	17386(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of Janus_kinase_3 -LRB- JAK3 -RRB- , matrix_metalloproteinase_13 -LRB- MMP13 -RRB- , heat_shock protein 60 -LRB- HSP60 -RRB- , and mouse double minute 2 -LRB- MDM2 -RRB- in human colorectal_cancer progression using human cancer cDNA microarrays .
23478800	0	Janus_tyrosine_kinase_2	132,155	Rac1	24,28	Janus tyrosine kinase 2	Rac1	3717	5879	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Cucurbitacin_I inhibits Rac1 activation in breast_cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus_tyrosine_kinase_2 and P-Rex1 .
15016718	0	Janus_tyrosine_kinase_2	35,58	signal_transducer_and_activator_of_transcription_5	59,109	Janus tyrosine kinase 2	signal transducer and activator of transcription 5	16452(Tax:10090)	20850(Tax:10090)	Gene	Gene	Suppression|nmod|START_ENTITY Suppression|parataxis|signaling signaling|nsubj|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- Janus_tyrosine_kinase_2 / signal_transducer_and_activator_of_transcription_5 signaling pathway in transgenic_mice overexpressing bovine GH .
22728763	0	Janus_tyrosine_kinase_3	10,33	CD4	89,92	Janus tyrosine kinase 3	CD4	16453(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|compound|END_ENTITY	Targeting Janus_tyrosine_kinase_3 -LRB- JAK3 -RRB- with an inhibitor induces secretion of TGF-b by CD4 + T cells .
22728763	0	Janus_tyrosine_kinase_3	10,33	TGF-b	80,85	Janus tyrosine kinase 3	TGF-b	16453(Tax:10090)	21803(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Targeting Janus_tyrosine_kinase_3 -LRB- JAK3 -RRB- with an inhibitor induces secretion of TGF-b by CD4 + T cells .
24649241	0	Jarid1b	16,23	Jumonji/Arid1b	0,14	Jarid1b	Jumonji/Arid1b	10765	57492	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Jumonji/Arid1b -LRB- Jarid1b -RRB- protein modulates human esophageal_cancer cell growth .
22110129	0	Jarid2	0,6	NOTCH1	57,63	Jarid2	NOTCH1	16468(Tax:10090)	18128(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Jarid2 -LRB- Jumonji , AT rich interactive domain 2 -RRB- regulates NOTCH1 expression via histone modification in the developing heart .
26190104	0	Jarid2	0,6	Nanog	19,24	Jarid2	Nanog	3720	79923	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development .
19010785	0	Jarid2	11,17	jumonji	2,9	Jarid2	jumonji	3720	3720	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	A jumonji -LRB- Jarid2 -RRB- protein complex represses cyclin_D1 expression by methylation of histone H3-K9 .
17285636	0	Jelly_Belly	11,22	RTK	58,61	Jelly Belly	RTK	36295(Tax:7227)	38559(Tax:7227)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The ligand Jelly_Belly -LRB- Jeb -RRB- activates the Drosophila Alk RTK to drive PC12 cell differentiation , but is unable to activate the mouse ALK RTK .
20876658	0	Jelly_belly	12,23	Mind_the_gap	96,108	Jelly belly	Mind the gap	36295(Tax:7227)	40970(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Anterograde Jelly_belly ligand to Alk receptor signaling at developing synapses is regulated by Mind_the_gap .
11152631	0	Jing	0,4	slbo	29,33	Jing	slbo	35555(Tax:7227)	37889(Tax:7227)	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	Jing : a downstream target of slbo required for developmental control of border cell migration .
16988490	0	Jmjd1a	18,24	STAT3	30,35	Jmjd1a	STAT3	104263(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of Jmjd1a as a STAT3 downstream gene in mES cells .
26795455	0	Jmjd3	20,25	Bcl-2	98,103	Jmjd3	Bcl-2	23135	596	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim .
21735477	0	Jmjd3	77,82	Nfatc1	115,121	Jmjd3	Nfatc1	23135	4772	Gene	Gene	START_ENTITY|nmod|demethylation demethylation|nmod|END_ENTITY	Epigenetic regulation of osteoclast differentiation : possible involvement of Jmjd3 in the histone demethylation of Nfatc1 .
26334721	0	Jmjd5	0,5	p53	34,37	Jmjd5	p53	77035(Tax:10090)	22059(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|regulator regulator|nmod|END_ENTITY	Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis .
26531897	0	Jmjd6	42,47	Aire	23,27	Jmjd6	Aire	107817(Tax:10090)	11634(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|regulation regulation|nmod|END_ENTITY	Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus .
26756900	0	Jnk	106,109	p53	54,57	Jnk	p53	5599	7157	Gene	Gene	activation|compound|START_ENTITY inhibition|nmod|activation suppresses|nmod|inhibition suppresses|dobj|accumulation accumulation|compound|END_ENTITY	COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation .
20564202	0	Jnk	43,46	wnt11	23,28	Jnk	wnt11	65236(Tax:7955)	791595(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation .
15867147	0	Jnk2	18,22	Mapk9	24,29	Jnk2	Mapk9	26420(Tax:10090)	26420(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of the Jnk2 -LRB- Mapk9 -RRB- gene reduces destructive insulitis and diabetes in a mouse model of type_I_diabetes .
16020535	0	Josephin	30,38	ataxin-3	49,57	Josephin	ataxin-3	4287	4287	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The solution structure of the Josephin domain of ataxin-3 : structural determinants for molecular recognition .
17096206	0	Josephin	28,36	ataxin-3	47,55	Josephin	ataxin-3	4287	4287	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Structure validation of the Josephin domain of ataxin-3 : conclusive evidence for an open conformation .
19382171	0	Josephin	0,8	ataxin-3	19,27	Josephin	ataxin-3	4287	4287	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites .
24251111	0	Josephin	95,103	ataxin-3	114,122	Josephin	ataxin-3	4287	4287	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Enzymatic production of mono-ubiquitinated proteins for structural studies : The example of the Josephin domain of ataxin-3 .
17384261	0	Jpk	0,3	Hoxa7	61,66	Jpk	Hoxa7	11827(Tax:10090)	15404(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Jpk , a novel cell death inducer , regulates the expression of Hoxa7 in F9 teratocarcinoma cells , but not during apoptosis .
15542826	0	Jumonji	0,7	atrial_natriuretic_factor	18,43	Jumonji	atrial natriuretic factor	16468(Tax:10090)	230899(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Jumonji represses atrial_natriuretic_factor gene expression by inhibiting transcriptional activities of cardiac transcription factors .
24649241	0	Jumonji/Arid1b	0,14	Jarid1b	16,23	Jumonji/Arid1b	Jarid1b	57492	10765	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Jumonji/Arid1b -LRB- Jarid1b -RRB- protein modulates human esophageal_cancer cell growth .
26896934	0	Jumonji_C-domain_containing_protein_6	8,45	JMJD6	47,52	Jumonji C-domain containing protein 6	JMJD6	23210	23210	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Jumonji_C-domain_containing_protein_6 -LRB- JMJD6 -RRB- in infectivity of foot-and-mouth_disease virus .
25079229	0	Jumonji_D3	63,73	JMJD3	75,80	Jumonji D3	JMJD3	216850(Tax:10090)	216850(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Stage-dependent and locus-specific role of histone demethylase Jumonji_D3 -LRB- JMJD3 -RRB- in the embryonic stages of lung development .
2497053	0	Jun	84,87	AP-1	69,73	Jun	AP-1	24516(Tax:10116)	24516(Tax:10116)	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	The product of a fos-related gene , fra-1 , binds cooperatively to the AP-1 site with Jun : transcription factor AP-1 is comprised of multiple protein complexes .
12437352	0	Jun	71,74	CBP	64,67	Jun	CBP	3725	1387	Gene	Gene	modes|nmod|START_ENTITY modes|nmod|END_ENTITY	Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB .
10036969	0	Jun	78,81	Fos	62,65	Jun	Fos	3725	2353	Gene	Gene	dimerization|compound|START_ENTITY peptides|nmod|dimerization peptides|compound|END_ENTITY	Uncoiling c-Jun coiled coils : inhibitory effects of truncated Fos peptides on Jun dimerization and DNA binding in vitro .
10188588	0	Jun	63,66	Fos	25,28	Jun	Fos	24516(Tax:10116)	314322(Tax:10116)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubjpass|translocation translocation|nmod|END_ENTITY	Nuclear translocation of Fos is stimulated by interaction with Jun through the leucine zipper .
11402340	0	Jun	18,21	Fos	24,27	Jun	Fos	424673(Tax:9031)	396512(Tax:9031)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Distinct roles of Jun : Fos and Jun : ATF dimers in oncogenesis .
1313772	0	Jun	91,94	Fos	0,3	Jun	Fos	3725	2353	Gene	Gene	terminus|nmod|START_ENTITY mediate|nsubj|terminus repress|parataxis|mediate repress|nsubj|END_ENTITY	Fos and Jun repress transcriptional activation by myogenin and MyoD : the amino terminus of Jun can mediate repression .
1594243	0	Jun	18,21	Fos	114,117	Jun	Fos	424673(Tax:9031)	396512(Tax:9031)	Gene	Gene	Transformation|nmod|START_ENTITY Transformation|dep|requirement requirement|nmod|END_ENTITY	Transformation by Jun : requirement for leucine zipper , basic region and transactivation domain and enhancement by Fos .
2111328	0	Jun	24,27	Fos	70,73	Jun	Fos	3725	2353	Gene	Gene	activity|nmod|START_ENTITY increased|nsubjpass|activity increased|nmod|END_ENTITY	DNA-binding activity of Jun is increased through its interaction with Fos .
2494630	0	Jun	34,37	Fos	102,105	Jun	Fos	3725	2353	Gene	Gene	oncoprotein|compound|START_ENTITY terminus|nmod|oncoprotein required|nsubjpass|terminus required|nmod|protein protein|compound|END_ENTITY	The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein .
2506451	0	Jun	29,32	Fos	2,5	Jun	Fos	3725	2353	Gene	Gene	zipper|compound|START_ENTITY containing|dobj|zipper protein|acl|containing protein|compound|END_ENTITY	A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the AP1 binding site .
2516828	0	Jun	40,43	Fos	58,61	Jun	Fos	3725	2353	Gene	Gene	formation|nmod|START_ENTITY requirements|nmod|formation requirements|dep|END_ENTITY	Different requirements for formation of Jun : Jun and Jun : Fos complexes .
2516828	0	Jun	45,48	Fos	58,61	Jun	Fos	3725	2353	Gene	Gene	requirements|dep|START_ENTITY requirements|dep|END_ENTITY	Different requirements for formation of Jun : Jun and Jun : Fos complexes .
3142691	0	Jun	39,42	Fos	68,71	Jun	Fos	16476(Tax:10090)	14281(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY activities|nmod|proteins activities|dep|stimulation stimulation|nmod|END_ENTITY	DNA binding activities of three murine Jun proteins : stimulation by Fos .
8140895	0	Jun	0,3	Fos	5,8	Jun	Fos	24516(Tax:10116)	314322(Tax:10116)	Gene	Gene	MyoD1|compound|START_ENTITY MyoD1|appos|END_ENTITY	Jun , Fos , MyoD1 , and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation .
11698665	0	Jun	55,58	JAC	0,3	Jun	JAC	3725	425968(Tax:9031)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	JAC , a direct target of oncogenic transcription factor Jun , is involved in cell transformation and tumorigenesis .
2516828	0	Jun	40,43	Jun	45,48	Jun	Jun	3725	3725	Gene	Gene	formation|nmod|START_ENTITY requirements|nmod|formation requirements|dep|END_ENTITY	Different requirements for formation of Jun : Jun and Jun : Fos complexes .
2516828	0	Jun	45,48	Jun	40,43	Jun	Jun	3725	3725	Gene	Gene	requirements|dep|START_ENTITY requirements|nmod|formation formation|nmod|END_ENTITY	Different requirements for formation of Jun : Jun and Jun : Fos complexes .
11818961	0	Jun	24,27	JunB	0,4	Jun	JunB	16476(Tax:10090)	16477(Tax:10090)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	JunB can substitute for Jun in mouse development and cell proliferation .
8043951	0	Jun	18,21	Junb	53,57	Jun	Junb	24516(Tax:10116)	24517(Tax:10116)	Gene	Gene	genes|compound|START_ENTITY Assignment|nmod|genes Assignment|nmod|chromosome chromosome|appos|END_ENTITY	Assignment of rat Jun family genes to chromosome 19 -LRB- Junb -RRB- , chromosome 5q31-33 -LRB- Jun -RRB- , and chromosome 16 -LRB- Jund -RRB- .
14720506	0	Jun	48,51	ZO-2	27,31	Jun	ZO-2	3725	9414	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	The tight junction protein ZO-2 associates with Jun , Fos and C/EBP transcription factors in epithelial cells .
2513128	0	Jun-B	0,5	c-Jun	81,86	Jun-B	c-Jun	3726	3725	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Jun-B differs in its biological properties from , and is a negative regulator of , c-Jun .
16086581	0	Jun-N-terminal_kinase	44,65	Raf	27,30	Jun-N-terminal kinase	Raf	5599	22882	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Functional interactions of Raf and MEK with Jun-N-terminal_kinase -LRB- JNK -RRB- result in a positive feedback loop on the oncogenic Ras signaling pathway .
12522006	0	JunB	49,53	C/EBPalpha	22,32	JunB	C/EBPalpha	3726	1050	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region .
15920551	0	JunB	0,4	CD30	39,43	JunB	CD30	3726	943	Gene	Gene	expression|compound|START_ENTITY feature|nsubj|expression feature|nmod|lymphomas lymphomas|compound|END_ENTITY	JunB expression is a common feature of CD30 + lymphomas and lymphomatoid_papulosis .
16140928	0	JunB	0,4	CD30	133,137	JunB	CD30	3726	943	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic_large_cell_lymphoma and reed-sternberg cells of Hodgkin_lymphoma .
16982741	0	JunB	123,127	CD30	18,22	JunB	CD30	3726	943	Gene	Gene	level|compound|START_ENTITY regulated|nmod|level regulated|nsubjpass|expression expression|nmod|END_ENTITY	The expression of CD30 in anaplastic_large_cell_lymphoma is regulated by nucleophosmin-anaplastic lymphoma kinase-mediated JunB level in a cell type-specific manner .
17965727	0	JunB	50,54	CD30	19,23	JunB	CD30	3726	943	Gene	Gene	expression|compound|START_ENTITY islands|nmod|expression islands|compound|END_ENTITY	Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin_lymphoma and anaplastic_large_cell_lymphoma .
17965727	0	JunB	50,54	CD30	73,77	JunB	CD30	3726	943	Gene	Gene	expression|compound|START_ENTITY islands|nmod|expression Hypomethylation|nmod|islands drives|nsubj|Hypomethylation drives|dobj|induction induction|nummod|END_ENTITY	Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin_lymphoma and anaplastic_large_cell_lymphoma .
18641637	0	JunB	10,14	G-CSF	25,30	JunB	G-CSF	16477(Tax:10090)	12985(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation .
10497240	0	JunB	58,62	Interleukin-6_and_leukemia_inhibitory_factor	0,44	JunB	Interleukin-6 and leukemia inhibitory factor	16477(Tax:10090)	16193;16878	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Interleukin-6_and_leukemia_inhibitory_factor induction of JunB is regulated by distinct cell type-specific cis-acting elements .
11818961	0	JunB	0,4	Jun	24,27	JunB	Jun	16477(Tax:10090)	16476(Tax:10090)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	JunB can substitute for Jun in mouse development and cell proliferation .
26318166	0	JunB	13,17	PDK1	0,4	JunB	PDK1	3726	5163	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	PDK1 induces JunB , EMT , cell migration and invasion in human gallbladder_cancer .
15084595	0	JunB	21,25	Smad3	0,5	JunB	Smad3	3726	4088	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Smad3 interacts with JunB and Cbfa1/Runx2 for transforming_growth_factor-beta1-stimulated collagenase-3 expression in human breast_cancer cells .
11602259	0	JunB	29,33	TAK1	0,4	JunB	TAK1	16477(Tax:10090)	26409(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nummod|END_ENTITY	TAK1 activation of the mouse JunB promoter is mediated through a CCAAT box and NF-Y .
8383624	0	JunB	0,4	c-Jun	18,23	JunB	c-Jun	3726	3725	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	JunB differs from c-Jun in its DNA-binding and dimerization domains , and represses c-Jun by formation of inactive heterodimers .
17204476	0	JunB	0,4	heme_oxygenase-1	29,45	JunB	heme oxygenase-1	3726	3162	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	JunB and JunD regulate human heme_oxygenase-1 gene expression in renal epithelial cells .
22391036	0	JunB	0,4	transforming_growth_factor-b	92,120	JunB	transforming growth factor-b	3726	7040	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming_growth_factor-b .
24136993	0	JunB	8,12	vascular_endothelial_growth_factor	48,82	JunB	vascular endothelial growth factor	16477(Tax:10090)	22339(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|production production|compound|END_ENTITY	Role of JunB in adenosine A2B receptor-mediated vascular_endothelial_growth_factor production .
15563473	0	JunD	77,81	AP-1	64,68	JunD	AP-1	16478(Tax:10090)	16476(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Menin suppresses osteoblast differentiation by antagonizing the AP-1 factor , JunD .
16157375	0	JunD	73,77	AP-1	47,51	JunD	AP-1	3727	3727	Gene	Gene	downregulation|nmod|START_ENTITY END_ENTITY|nmod|downregulation	Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines .
20460526	0	JunD	27,31	Androgen_receptor	0,17	JunD	Androgen receptor	3727	367	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Androgen_receptor requires JunD as a coactivator to switch on an oxidative stress generation pathway in prostate_cancer cells .
22990073	0	JunD	76,80	CD11c	40,45	JunD	CD11c	16478(Tax:10090)	16411(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells .
15044019	0	JunD	19,23	HBZ	0,3	JunD	HBZ	3727	3050	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HBZ interacts with JunD and stimulates its transcriptional activity .
16264271	0	JunD	16,20	Nur77	81,86	JunD	Nur77	3727	3164	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Menin represses JunD transcriptional activity in protein_kinase_C theta-mediated Nur77 expression .
7969116	0	JunD	15,19	nur77	78,83	JunD	nur77	24518(Tax:10116)	79240(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY END_ENTITY|nsubj|Involvement	Involvement of JunD in transcriptional activation of the orphan_receptor gene nur77 by nerve_growth_factor and membrane depolarization in PC12 cells .
11476966	0	Jun_N-terminal_kinase	10,31	JNK	33,36	Jun N-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Prolonged Jun_N-terminal_kinase -LRB- JNK -RRB- activation and the upregulation of p53 and p21 -LRB- WAF1/CIP1 -RRB- preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin .
15536494	0	Jun_N-terminal_kinase	14,35	JNK	37,40	Jun N-terminal kinase	JNK	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of Jun_N-terminal_kinase -LRB- JNK -RRB- enhances glucocorticoid receptor-mediated function in mouse hippocampal HT22 cells .
19289495	0	Jun_N-terminal_kinase	93,114	MEKK4	73,78	Jun N-terminal kinase	MEKK4	26419(Tax:10090)	26407(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Trophoblast stem cell maintenance by fibroblast_growth_factor_4 requires MEKK4 activation of Jun_N-terminal_kinase .
17277363	0	Jun_N-terminal_kinase	73,94	PP1beta	33,40	Jun N-terminal kinase	PP1beta	44801(Tax:7227)	49260(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The nonmuscle myosin phosphatase PP1beta -LRB- flapwing -RRB- negatively regulates Jun_N-terminal_kinase in wing imaginal discs of Drosophila .
16168987	0	Jun_N-terminal_kinase	138,159	activator_protein-1	160,179	Jun N-terminal kinase	activator protein-1	116554(Tax:10116)	24516(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly _ -LRB- ADP-ribose -RRB- polymerase activity and Jun_N-terminal_kinase / activator_protein-1 pathway inhibition .
17322004	0	Jun_N-terminal_kinase	91,112	inducible_nitric-oxide_synthase	41,72	Jun N-terminal kinase	inducible nitric-oxide synthase	5599	4843	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Post-transcriptional regulation of human inducible_nitric-oxide_synthase expression by the Jun_N-terminal_kinase .
17403137	0	Jun_N-terminal_kinase	146,167	mitogen_activated_protein_kinase_phosphatase-1	75,121	Jun N-terminal kinase	mitogen activated protein kinase phosphatase-1	116554(Tax:10116)	114856(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dexamethasone suppresses monocyte_chemoattractant_protein-1 production via mitogen_activated_protein_kinase_phosphatase-1 dependent inhibition of Jun_N-terminal_kinase and p38_mitogen-activated_protein_kinase in activated rat microglia .
14736735	0	Jun_N-terminal_kinase	39,60	p38	62,65	Jun N-terminal kinase	p38	5599	5594	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Extracellular signal-regulated kinase , Jun_N-terminal_kinase , p38 , and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone beta-subunit promoter .
12809946	0	Jun_N-terminal_kinase	0,21	p53	53,56	Jun N-terminal kinase	p53	116554(Tax:10116)	301300(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Jun_N-terminal_kinase activation and upregulation of p53 and p21 -LRB- WAF1/CIP1 -RRB- in selenite-induced apoptosis of regenerating liver .
8940056	0	Jun_N-terminal_kinase	0,21	skeletal_muscle_glycogen_synthase	45,78	Jun N-terminal kinase	skeletal muscle glycogen synthase	5599	2997	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Jun_N-terminal_kinase mediates activation of skeletal_muscle_glycogen_synthase by insulin in vivo .
19112600	0	Jun_N-terminal_kinases	16,38	Leptin	0,6	Jun N-terminal kinases	Leptin	5599	3952	Gene	Gene	utilizes|dobj|START_ENTITY utilizes|nsubj|END_ENTITY	Leptin utilizes Jun_N-terminal_kinases to stimulate the invasion of MCF-7_breast_cancer cells .
11283254	0	Jun_NH2-terminal_kinase	0,23	p53	43,46	Jun NH2-terminal kinase	p53	5599	7157	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Jun_NH2-terminal_kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress .
11283254	0	Jun_NH2-terminal_kinase	0,23	p53	74,77	Jun NH2-terminal kinase	p53	5599	7157	Gene	Gene	phosphorylation|amod|START_ENTITY important|nsubj|phosphorylation important|nmod|stabilization stabilization|nummod|END_ENTITY	Jun_NH2-terminal_kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress .
12782606	0	Jun_activation_domain-binding_protein_1	0,39	Kip1	123,127	Jun activation domain-binding protein 1	Kip1	10987	1027	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|p27 p27|appos|END_ENTITY	Jun_activation_domain-binding_protein_1 expression in breast_cancer inversely correlates with the cell cycle inhibitor p27 -LRB- Kip1 -RRB- .
16175894	0	Jun_activation_domain-binding_protein_1	14,53	Kip1	63,67	Jun activation domain-binding protein 1	Kip1	10987	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Jun_activation_domain-binding_protein_1 and p27 -LRB- Kip1 -RRB- in thyroid medullary_carcinoma .
17133595	0	Jun_activation_domain-binding_protein_1	0,39	Smad5	46,51	Jun activation domain-binding protein 1	Smad5	10987	4090	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Jun_activation_domain-binding_protein_1 binds Smad5 and inhibits bone morphogenetic protein signaling .
12782606	0	Jun_activation_domain-binding_protein_1	0,39	p27	119,122	Jun activation domain-binding protein 1	p27	10987	3429	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Jun_activation_domain-binding_protein_1 expression in breast_cancer inversely correlates with the cell cycle inhibitor p27 -LRB- Kip1 -RRB- .
16721818	0	Jun_activation_domain-binding_protein_1	18,57	p27	111,114	Jun activation domain-binding protein 1	p27	10987	10534	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|expression expression|amod|END_ENTITY	Overexpression of Jun_activation_domain-binding_protein_1 in nonsmall_cell_lung_cancer and its significance in p27 expression and clinical features .
19139918	0	Jun_activation_domain-binding_protein_1	14,53	p27	79,82	Jun activation domain-binding protein 1	p27	10987	10671	Gene	Gene	Expression|nmod|START_ENTITY phosphorylated|nsubj|Expression phosphorylated|dobj|protein protein|amod|END_ENTITY	Expression of Jun_activation_domain-binding_protein_1 and Ser10 phosphorylated p27 protein in human epithelial_ovarian_carcinoma .
21837501	0	Jun_activation_domain-binding_protein_1	18,57	p27	77,80	Jun activation domain-binding protein 1	p27	10987	3429	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Potential role of Jun_activation_domain-binding_protein_1 and phosphorylated p27 expression in prognosis of glioma .
22311264	0	Jun_activation_domain-binding_protein_1	0,39	p27	135,138	Jun activation domain-binding protein 1	p27	10987	3429	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Jun_activation_domain-binding_protein_1 expression in oral_squamous_cell_carcinomas inversely correlates with the cell cycle inhibitor p27 .
18285702	0	Jun_activation_domain-binding_protein_1	0,39	p27_kip1	60,68	Jun activation domain-binding protein 1	p27 kip1	10987	1027	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Jun_activation_domain-binding_protein_1 negatively regulate p27_kip1 in non-Hodgkin 's _ lymphomas .
16951171	0	Jun_activation_domain-binding_protein_1	18,57	p27kip1	85,92	Jun activation domain-binding protein 1	p27kip1	10987	1027	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Potential role of Jun_activation_domain-binding_protein_1 as a negative regulator of p27kip1 in pancreatic_adenocarcinoma .
11231009	0	Jun_dimerization_protein_2	24,50	ATF-2	75,80	Jun dimerization protein 2	ATF-2	81703(Tax:10090)	11909(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of mouse Jun_dimerization_protein_2 as a novel repressor of ATF-2 .
21525011	0	Jun_dimerization_protein_2	15,41	JDP2	43,47	Jun dimerization protein 2	JDP2	122953	122953	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Jun_dimerization_protein_2 -LRB- JDP2 -RRB- in the maintenance of Epstein-Barr_virus latency .
8562955	0	Jun_kinase	35,45	CD45	74,78	Jun kinase	CD45	5601	5788	Gene	Gene	independently|compound|START_ENTITY independently|nmod|END_ENTITY	Fas ligation induces apoptosis and Jun_kinase activation independently of CD45 and Lck in human T cells .
9224720	0	Jun_kinase	11,21	DJun	127,131	Jun kinase	DJun	44801(Tax:7227)	36057(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Drosophila Jun_kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure .
12417721	0	Jun_kinase	86,96	tumor_necrosis_factor	108,129	Jun kinase	tumor necrosis factor	5601	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The p65/RelA subunit of NF-kappaB suppresses the sustained , antiapoptotic activity of Jun_kinase induced by tumor_necrosis_factor .
8043951	0	Junb	53,57	Jun	18,21	Junb	Jun	24517(Tax:10116)	24516(Tax:10116)	Gene	Gene	chromosome|appos|START_ENTITY Assignment|nmod|chromosome Assignment|nmod|genes genes|compound|END_ENTITY	Assignment of rat Jun family genes to chromosome 19 -LRB- Junb -RRB- , chromosome 5q31-33 -LRB- Jun -RRB- , and chromosome 16 -LRB- Jund -RRB- .
11489913	0	Junctional_adhesion_molecule	0,28	PAR-3	44,49	Junctional adhesion molecule	PAR-3	50848	56288	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Junctional_adhesion_molecule -LRB- JAM -RRB- binds to PAR-3 : a possible mechanism for the recruitment of PAR-3 to tight junctions .
11489913	0	Junctional_adhesion_molecule	0,28	PAR-3	95,100	Junctional adhesion molecule	PAR-3	50848	56288	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|mechanism mechanism|nmod|recruitment recruitment|nmod|junctions junctions|amod|tight tight|amod|END_ENTITY	Junctional_adhesion_molecule -LRB- JAM -RRB- binds to PAR-3 : a possible mechanism for the recruitment of PAR-3 to tight junctions .
20378847	0	Junctional_adhesion_molecule_A	0,30	CD34	50,54	Junctional adhesion molecule A	CD34	50848	947	Gene	Gene	START_ENTITY|acl|expressed expressed|nmod|cells cells|compound|END_ENTITY	Junctional_adhesion_molecule_A expressed on human CD34 + cells promotes adhesion on vascular wall and differentiation into endothelial progenitor cells .
25209248	0	Juno	53,57	Izumo1	25,31	Juno	Izumo1	390243	284359	Gene	Gene	drives|nsubj|START_ENTITY drives|dep|Binding Binding|nmod|END_ENTITY	Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilization .
25533103	0	Juno	55,59	Izumo1	91,97	Juno	Izumo1	390243	284359	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Cross-species fertilization : the hamster egg receptor , Juno , binds the human sperm ligand , Izumo1 .
3818598	0	K	74,75	kininogen	82,91	K	kininogen	288001(Tax:10116)	288001(Tax:10116)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Differing utilization of homologous transcription initiation sites of rat K and T kininogen genes under inflammation condition .
15742156	0	K-12	29,33	IFN-gamma	82,91	K-12	IFN-gamma	3859	3458	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|regulation regulation|nmod|END_ENTITY	Expression of the CD7 ligand K-12 in human thymic epithelial cells : regulation by IFN-gamma .
3034844	0	K-13	0,4	angiotensin_I_converting_enzyme	27,58	K-13	angiotensin I converting enzyme	287699(Tax:10116)	24310(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	K-13 , a novel inhibitor of angiotensin_I_converting_enzyme produced by Micromonospora halophytica subsp .
3034845	0	K-13	0,4	angiotensin_I_converting_enzyme	27,58	K-13	angiotensin I converting enzyme	3860	1636	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	K-13 , a novel inhibitor of angiotensin_I_converting_enzyme produced by Micromonospora halophytica subsp .
3005218	0	K-26	0,4	angiotensin_I_converting_enzyme	27,58	K-26	angiotensin I converting enzyme	353288	1636	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	K-26 , a novel inhibitor of angiotensin_I_converting_enzyme produced by an actinomycete K-26 .
3009378	0	K-4	0,3	angiotensin_I_converting_enzyme	26,57	K-4	angiotensin I converting enzyme	315323(Tax:10116)	24310(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	K-4 , a novel inhibitor of angiotensin_I_converting_enzyme produced by Actinomadura spiculosospora .
9950760	0	K-Cl_cotransporter	30,48	KCC1	50,54	K-Cl cotransporter	KCC1	6560	6560	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Functional interaction of the K-Cl_cotransporter -LRB- KCC1 -RRB- with the Na-K-Cl_cotransporter in HEK-293 cells .
21392397	0	K-RAS	20,25	YB-1	29,33	K-RAS	YB-1	3845	4904	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation .
22043453	0	K-Ras	55,60	C-Raf	0,5	K-Ras	C-Raf	16653(Tax:10090)	110157(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	C-Raf is required for the initiation of lung_cancer by K-Ras -LRB- G12D -RRB- .
20375073	0	K-Ras	39,44	E-cadherin	14,24	K-Ras	E-cadherin	3845	999	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of E-cadherin expression by K-Ras ; involvement of DNA_methyltransferase-3b .
22342683	0	K-Ras	0,5	ERK	47,50	K-Ras	ERK	3845	5594	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic_ductal_adenocarcinomas .
24215674	0	K-Ras	57,62	ERK	71,74	K-Ras	ERK	3845	5594	Gene	Gene	oleanane_triterpenoid|dobj|START_ENTITY oleanane_triterpenoid|nmod|END_ENTITY	Novel synthetic oleanane_triterpenoid AMR-MeOAc inhibits K-Ras through ERK , Akt and survivin in pancreatic_cancer cells .
21441955	0	K-Ras	7,12	GSK-3b	23,29	K-Ras	GSK-3b	3845	2932	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Mutant K-Ras increases GSK-3b gene expression via an ETS-p300 transcriptional complex in pancreatic_cancer .
17460778	0	K-Ras	10,15	H-Ras	79,84	K-Ras	H-Ras	3845	3265	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Oncogenic K-Ras signals through epidermal_growth_factor_receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal_carcinoma cells .
24462863	0	K-Ras	73,78	H-Ras	53,58	K-Ras	H-Ras	3845	3265	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function .
27057007	0	K-Ras	53,58	H-Ras	78,83	K-Ras	H-Ras	3845	3265	Gene	Gene	dimers|compound|START_ENTITY differ|nsubj|dimers differ|nmod|dimers dimers|compound|END_ENTITY	Membrane-associated Ras dimers are isoform-specific : K-Ras dimers differ from H-Ras dimers .
19029954	0	K-Ras	21,26	Hdm2	0,4	K-Ras	Hdm2	3845	4193	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic_cancer cells .
24462863	0	K-Ras	34,39	IQGAP1	0,6	K-Ras	IQGAP1	3845	8826	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function .
22195963	0	K-Ras	7,12	MST2	44,48	K-Ras	MST2	3845	6788	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras .
23459937	0	K-Ras	50,55	MST2	59,63	K-Ras	MST2	3845	6788	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics .
20585519	0	K-Ras	37,42	Nucleophosmin	0,13	K-Ras	Nucleophosmin	3845	4869	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Nucleophosmin and nucleolin regulate K-Ras signaling .
14745729	0	K-Ras	12,17	P53	0,3	K-Ras	P53	3845	7157	Gene	Gene	N|dep|START_ENTITY N|compound|END_ENTITY	P53 , N - and K-Ras , and beta-catenin gene mutations and prognostic factors in nasal NK/T-cell _ lymphoma from Hokkaido , Japan .
16257181	0	K-Ras	10,15	Rac1	31,35	K-Ras	Rac1	3845	5879	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic_carcinoma cells through activation of p38 .
17332339	0	K-Ras	0,5	Raf	92,95	K-Ras	Raf	3845	22882	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol_3-kinase signaling .
12594205	0	K-Ras	82,87	Suprachiasmatic_nucleus_circadian_oscillatory_protein	0,53	K-Ras	Suprachiasmatic nucleus circadian oscillatory protein	24525(Tax:10116)	59265(Tax:10116)	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Suprachiasmatic_nucleus_circadian_oscillatory_protein , a novel binding partner of K-Ras in the membrane rafts , negatively regulates MAPK pathway .
22411898	0	K-Ras	160,165	TUBB3	5,10	K-Ras	TUBB3	3845	10381	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	High TUBB3 expression , an independent prognostic marker in patients with early non-small_cell_lung_cancer treated by preoperative chemotherapy , is regulated by K-Ras signaling pathway .
22826122	0	K-Ras	0,5	c-myc	99,104	K-Ras	c-myc	3845	4609	Gene	Gene	oncogenes|amod|START_ENTITY inhibit|nsubj|oncogenes inhibit|nmod|up-regulation up-regulation|nmod|END_ENTITY	K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc .
20802526	0	K-Ras	75,80	calmodulin	50,60	K-Ras	calmodulin	3845	808	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function .
19107228	0	K-Ras	53,58	p53	69,72	K-Ras	p53	3845	7157	Gene	Gene	promoted|nmod|START_ENTITY Blocking|acl|promoted recovers|nsubj|Blocking recovers|dobj|expression expression|compound|END_ENTITY	Blocking of p53-Snail binding , promoted by oncogenic K-Ras , recovers p53 expression and function .
24344114	0	K-Ras	37,42	p53	14,17	K-Ras	p53	3845	7157	Gene	Gene	START_ENTITY|nsubj|re-enters re-enters|compound|END_ENTITY	Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system .
12763212	0	K-ras	27,32	CD34	52,56	K-ras	CD34	3845	947	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
25305448	0	K-ras	8,13	CDK8	24,28	K-ras	CDK8	16653(Tax:10090)	264064(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic_cancer in part via the Wnt/b-catenin signaling pathway .
11162624	0	K-ras	35,40	ERK	50,53	K-ras	ERK	3845	5594	Gene	Gene	cells|nmod|START_ENTITY suppress|nsubj|cells suppress|dobj|activity activity|compound|END_ENTITY	Pancreatic_tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP_kinase_phosphatase-2 .
15699632	0	K-ras	53,58	ERK1/2	36,42	K-ras	ERK1/2	3845	5595;5594	Gene	Gene	activated|nmod|START_ENTITY activated|nmod|END_ENTITY	Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells .
10402237	0	K-ras	86,91	Erk	29,32	K-ras	Erk	3845	5594	Gene	Gene	expression|compound|START_ENTITY MAP|nmod|expression MAP|dobj|activity activity|appos|END_ENTITY	Lack of elevated MAP kinase -LRB- Erk -RRB- activity in pancreatic_carcinomas despite oncogenic K-ras expression .
15699632	0	K-ras	53,58	Ets1	0,4	K-ras	Ets1	3845	2113	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells .
12460470	0	K-ras	58,63	H-ras	65,70	K-ras	H-ras	3845	3265	Gene	Gene	N-ras|dep|START_ENTITY N-ras|dep|END_ENTITY	Molecular analysis of oncogenes , ras family genes -LRB- N-ras , K-ras , H-ras -RRB- , myc family genes -LRB- c-myc , N-myc -RRB- and mdm2 in natural killer cell neoplasms .
9815992	0	K-ras	13,18	H-ras	43,48	K-ras	H-ras	3845	3265	Gene	Gene	oncogene|compound|START_ENTITY oncogene|nmod|mutations mutations|compound|END_ENTITY	Mutations of K-ras oncogene and absence of H-ras mutations in squamous_cell_carcinomas of the lung .
26168827	0	K-ras	73,78	P53	80,83	K-ras	P53	3845	7157	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	Evaluation of Intraductal Ultrasonography , Endoscopic Brush Cytology and K-ras , P53 Gene Mutation in the Early Diagnosis of Malignant Bile_Duct_Stricture .
12763212	0	K-ras	27,32	PCNA	46,50	K-ras	PCNA	3845	5111	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
16679305	0	K-ras	0,5	Raf	42,45	K-ras	Raf	3845	22882	Gene	Gene	Asp12|amod|START_ENTITY mutant|nsubj|Asp12 mutant|nmod|END_ENTITY	K-ras Asp12 mutant neither interacts with Raf , nor signals through Erk and is less tumorigenic than K-ras Val12 .
17369402	0	K-ras	30,35	Sprouty-2	0,9	K-ras	Sprouty-2	3845	10253	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis .
22471946	0	K-ras	60,65	Syndecan-2	0,10	K-ras	Syndecan-2	3845	6383	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic_cancer cell phenotype .
12763212	0	K-ras	27,32	bcl-2	39,44	K-ras	bcl-2	3845	596	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
21528323	0	K-ras	12,17	bcl-2	24,29	K-ras	bcl-2	3845	596	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|expression expression|amod|END_ENTITY	Analysis of K-ras , p53 , bcl-2 and Rb expression in non-small_cell_lung_cancer cell lines .
12460470	0	K-ras	58,63	c-myc	91,96	K-ras	c-myc	3845	4609	Gene	Gene	N-ras|dep|START_ENTITY genes|appos|N-ras analysis|appos|genes myc|nsubj|analysis myc|dobj|genes genes|appos|END_ENTITY	Molecular analysis of oncogenes , ras family genes -LRB- N-ras , K-ras , H-ras -RRB- , myc family genes -LRB- c-myc , N-myc -RRB- and mdm2 in natural killer cell neoplasms .
14764072	0	K-ras	0,5	gastrin	55,62	K-ras	gastrin	3845	2520	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	K-ras and B-raf gene mutations are not associated with gastrin - and CCK2-receptor mRNA expression in human colorectal_tumour tissues .
12805379	0	K-ras	0,5	matrix_metalloproteinase_2	47,73	K-ras	matrix metalloproteinase 2	3845	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	K-ras regulates the steady-state expression of matrix_metalloproteinase_2 in fibroblasts .
11195463	0	K-ras	0,5	p21	6,9	K-ras	p21	16653(Tax:10090)	12575(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	K-ras p21 expression and activity in lung and lung_tumors .
10353750	0	K-ras	157,162	p53	26,29	K-ras	p53	3845	7157	Gene	Gene	mutation|compound|START_ENTITY comparison|nmod|mutation Detection|dep|comparison Detection|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic_cancer : comparison with K-ras mutation .
11836595	0	K-ras	52,57	p53	18,21	K-ras	p53	3845	7157	Gene	Gene	genes|compound|START_ENTITY protein|nmod|genes protein|compound|END_ENTITY	Overexpression of p53 protein and point mutation of K-ras genes in primary_carcinoma of the small intestine .
12374683	0	K-ras	0,5	p53	16,19	K-ras	p53	3845	7157	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|overexpression overexpression|compound|END_ENTITY	K-ras mutation , p53 overexpression , and microsatellite_instability in biliary_tract_cancers : a population-based study in China .
12763212	0	K-ras	27,32	p53	34,37	K-ras	p53	3845	7157	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
12911661	0	K-ras	16,21	p53	0,3	K-ras	p53	3845	7157	Gene	Gene	mutation|compound|START_ENTITY expression|appos|mutation expression|compound|END_ENTITY	p53 expression , K-ras gene mutation and microsatellite_instability in gastric_B-cell_lymphomas .
15824025	0	K-ras	0,5	p53	36,39	K-ras	p53	16653(Tax:10090)	22060(Tax:10090)	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|lung_tumors lung_tumors|nmod|mice mice|nummod|END_ENTITY	K-ras mutations in lung_tumors from p53 mutant mice exposed to cigarette smoke .
18283039	0	K-ras	79,84	p53	85,88	K-ras	p53	16653(Tax:10090)	22060(Tax:10090)	Gene	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	Telomere_dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung_cancer .
21528323	0	K-ras	12,17	p53	19,22	K-ras	p53	3845	7157	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of K-ras , p53 , bcl-2 and Rb expression in non-small_cell_lung_cancer cell lines .
21952947	0	K-ras	116,121	p53	24,27	K-ras	p53	3845	7157	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Gain-of-function mutant p53 but not p53 deletion promotes head_and_neck_cancer progression in response to oncogenic K-ras .
23168708	0	K-ras	17,22	p53	12,15	K-ras	p53	3845	7157	Gene	Gene	Helicobacter_pylori_infection|compound|START_ENTITY END_ENTITY|appos|Helicobacter_pylori_infection	Analysis of p53 , K-ras gene mutation _ Helicobacter_pylori_infection in patients with gastric_cancer _ peptic_ulcer_disease at a tertiary care hospital in north India .
24038521	0	K-ras	28,33	p53	8,11	K-ras	p53	3845	7157	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|compound|END_ENTITY	Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner .
25857071	0	K-ras	11,16	p53	18,21	K-ras	p53	3845	7157	Gene	Gene	START_ENTITY|dep|DPC4 DPC4|compound|END_ENTITY	-LSB- Oncogene -LRB- K-ras , p53 , p16 , DPC4 , hTERTmRNA -RRB- -RSB- .
7586136	0	K-ras	57,62	p53	26,29	K-ras	p53	16653(Tax:10090)	22060(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|mutations mutations|nmod|gene gene|compound|END_ENTITY	Frequent mutations of the p53 gene and infrequent H - and K-ras mutations in urinary_bladder_carcinomas of NON/Shi mice treated with N-butyl-N - -LRB- 4-hydroxybutyl -RRB- nitrosamine .
7835585	0	K-ras	28,33	p53	60,63	K-ras	p53	3845	7157	Gene	Gene	START_ENTITY|dep|activation activation|nmod|accumulation accumulation|compound|END_ENTITY	Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant_crypt_foci of the colon .
7852189	0	K-ras	68,73	p53	18,21	K-ras	p53	3845	7157	Gene	Gene	activation|compound|START_ENTITY occurs|nmod|activation occurs|nsubj|Alteration Alteration|nmod|gene gene|compound|END_ENTITY	Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial_tumors of the human ovary .
7914949	0	K-ras	41,46	p53	79,82	K-ras	p53	3845	7157	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|overexpression overexpression|nmod|protein protein|compound|END_ENTITY	Prognostic factors of colorectal_cancer : K-ras mutation , overexpression of the p53 protein , and cell proliferative activity .
8121190	0	K-ras	9,14	p53	40,43	K-ras	p53	3845	7157	Gene	Gene	START_ENTITY|dep|mutations mutations|nmod|mutations mutations|compound|END_ENTITY	Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas .
9230291	0	K-ras	21,26	p53	103,106	K-ras	p53	16653(Tax:10090)	22060(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY incidence|nmod|mutations incidence|acl|carrying carrying|dobj|transgene transgene|compound|END_ENTITY	Similar incidence of K-ras mutations in lung_carcinomas of FVB/N _ mice and FVB/N _ mice carrying a mutant p53 transgene .
9402497	0	K-ras	78,83	p53	66,69	K-ras	p53	3845	7157	Gene	Gene	mutation|compound|START_ENTITY expressing|nmod|mutation expressing|dobj|END_ENTITY	Carcinoma_of_the_colon in childhood ; report of 2 cases expressing p53 without K-ras mutation .
14989985	0	K-ras4B	22,29	estrogen_receptor	61,78	K-ras4B	estrogen receptor	3845	2099	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Regulation of -LSB- 12Asp -RSB- K-ras4B on transcriptional activity of estrogen_receptor in endometrial_carcinoma HEC-1A cell lines -RSB- .
18761727	0	K1-3	12,16	E-selectin	25,35	K1-3	E-selectin	3860	6401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Angiostatin K1-3 induces E-selectin via AP1 and Ets1 : a mediator for anti-angiogenic action of K1-3 .
18761727	0	K1-3	95,99	E-selectin	25,35	K1-3	E-selectin	3860	6401	Gene	Gene	action|nmod|START_ENTITY mediator|nmod|action END_ENTITY|dep|mediator	Angiostatin K1-3 induces E-selectin via AP1 and Ets1 : a mediator for anti-angiogenic action of K1-3 .
10652336	0	K12	48,51	SECTM1	53,59	K12	SECTM1	3859	6398	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of CD7 as a cognate of the human K12 -LRB- SECTM1 -RRB- protein .
21531730	0	K13	103,106	A20	0,3	K13	A20	3860	7128	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	A20 is induced by Kaposi_sarcoma-associated herpesvirus-encoded viral FLICE inhibitory protein -LRB- vFLIP -RRB- K13 and blocks K13-induced nuclear factor-kappaB in a negative feedback manner .
20023696	0	K13	87,90	CXCR4	102,107	K13	CXCR4	3860	7852	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus-encoded viral FLICE inhibitory protein -LRB- vFLIP -RRB- K13 suppresses CXCR4 expression by upregulating miR-146a .
9154804	0	K3_keratin	14,24	Sp1	47,50	K3 keratin	Sp1	100353668(Tax:9986)	100351317(Tax:9986)	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of K3_keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells .
24382117	3	K5/14	677,682	p63	672,675	K5/14	p63	3852;3861	8626	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	METHODS AND RESULTS : Using triple immunofluorescence labelling and quantitative RT-PCR for keratins , p63 , and smooth muscle actin , we demonstrated that syringomatous_tumour and LGAdSC contain p63 + / K5/14 + tumour cells , K10 + squamous cells , and K8/18 + glandular cells , with intermediary cells being found in both lineages .
10887174	1	K6b	94,97	Tumor_necrosis_factor_alpha	58,85	K6b	Tumor necrosis factor alpha	3854	7124	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa_B and C/EBPbeta .
23617728	0	KAI-1	83,88	COX-2	55,60	KAI-1	COX-2	12521(Tax:10090)	17709(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Papillary_carcinoma of the thyroid : high expression of COX-2 and low expression of KAI-1 / CD82 are associated with increased tumor invasiveness .
17621632	0	KAI-1	49,54	c-Met	14,19	KAI-1	c-Met	3732	4233	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of c-Met signaling by the tetraspanin KAI-1 / CD82 affects cancer cell migration .
16862154	0	KAI1	15,19	DARC	40,44	KAI1	DARC	3732	2532	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression .
22390300	0	KAI1	0,4	HIF-1a	16,22	KAI1	HIF-1a	3732	3091	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	KAI1 suppresses HIF-1a and VEGF expression by blocking CDCP1-enhanced Src activation in prostate_cancer .
15205336	0	KAI1	105,109	KAI1_COOH-terminal_interacting_tetraspanin	0,42	KAI1	KAI1 COOH-terminal interacting tetraspanin	12521(Tax:10090)	229658(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	KAI1_COOH-terminal_interacting_tetraspanin -LRB- KITENIN -RRB- , a member of the tetraspanin family , interacts with KAI1 , a tumor metastasis suppressor , and enhances metastasis of cancer .
18037895	0	KAI1	67,71	gp78	21,25	KAI1	gp78	3732	267	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation .
20089858	0	KAI1	11,15	gp78	88,92	KAI1	gp78	3732	267	Gene	Gene	role|nmod|START_ENTITY role|nmod|proliferation proliferation|nmod|ligase ligase|amod|END_ENTITY	A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase .
12810384	0	KAI1	33,37	tumor_suppressor	11,27	KAI1	tumor suppressor	3732	7248	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|gene gene|compound|END_ENTITY	-LSB- Effect of tumor_suppressor gene KAI1 on the biological behaviors of human colorectal_carcinoma -RSB- .
15205336	0	KAI1_COOH-terminal_interacting_tetraspanin	0,42	KAI1	105,109	KAI1 COOH-terminal interacting tetraspanin	KAI1	229658(Tax:10090)	12521(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	KAI1_COOH-terminal_interacting_tetraspanin -LRB- KITENIN -RRB- , a member of the tetraspanin family , interacts with KAI1 , a tumor metastasis suppressor , and enhances metastasis of cancer .
14521834	0	KAP	11,14	KLP64D	59,65	KAP	KLP64D	32071(Tax:7227)	38611(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Drosophila KAP interacts with the kinesin_II motor subunit KLP64D to assemble chordotonal sensory cilia , but not sperm tails .
24704824	0	KAP	0,3	ROCK2	14,19	KAP	ROCK2	1033	9475	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway .
7569954	0	KAP	88,91	cyclin	110,116	KAP	cyclin	1033	5111	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin .
1991048	0	KAP	86,89	kidney_androgen-regulated_protein	51,84	KAP	kidney androgen-regulated protein	16483(Tax:10090)	16483(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and DNA sequence of the mouse kidney_androgen-regulated_protein -LRB- KAP -RRB- gene .
21153285	0	KAP	84,87	kidney_androgen-regulated_protein	49,82	KAP	kidney androgen-regulated protein	24937(Tax:10116)	24937(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Cell-specific and hormonal regulation of the rat kidney_androgen-regulated_protein -LRB- KAP -RRB- gene .
10669749	0	KAP	49,52	kinase-associated_phosphatase	18,47	KAP	kinase-associated phosphatase	1033	1033	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of kinase-associated_phosphatase -LRB- KAP -RRB- in breast_and_prostate_cancer and inhibition of the transformed phenotype by antisense KAP expression .
17704056	0	KAP1	55,59	E2F1	14,18	KAP1	E2F1	10155	1869	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of E2F1 function by the nuclear corepressor KAP1 .
23645696	0	KAP1	141,145	HP1a	178,182	KAP1	HP1a	10155	23468	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Phosphorylation of KRAB-associated_protein_1 -LRB- KAP1 -RRB- at Tyr-449 , Tyr-458 , and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin_protein_1a -LRB- HP1a -RRB- with heterochromatin .
16107876	0	KAP1	42,46	MDM2	0,4	KAP1	MDM2	10155	4193	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation .
25585209	0	KAP1	0,4	PRMT5	61,66	KAP1	PRMT5	10155	10419	Gene	Gene	Substrate|nsubj|START_ENTITY Substrate|nmod|END_ENTITY	KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5 .
23954693	0	KAP1	57,61	Zfp819	0,6	KAP1	Zfp819	21849(Tax:10090)	74400(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Zfp819 , a novel KRAB-zinc_finger_protein , interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells .
26725010	0	KAP1	0,4	snRNP	28,33	KAP1	snRNP	10155	57819	Gene	Gene	Recruitment|compound|START_ENTITY Recruitment|nmod|END_ENTITY	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II .
21400094	0	KAP11-1	28,35	KRTAP11-1	42,51	KAP11-1	KRTAP11-1	16693(Tax:10090)	100607967	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of the ovine KAP11-1 gene -LRB- KRTAP11-1 -RRB- and genetic variation in its coding sequence .
22995344	0	KAP24-1	77,84	keratin-associated_protein_24-1	44,75	KAP24-1	keratin-associated protein 24-1	101116882	101116882	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and sequence analysis of the keratin-associated_protein_24-1 -LRB- KAP24-1 -RRB- gene homologue in sheep .
8423809	0	KAR2	33,37	BiP	39,42	KAR2	BiP	853418(Tax:4932)	3309	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The promoter region of the yeast KAR2 -LRB- BiP -RRB- gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum .
24750026	0	KAT2A	93,98	MBD5	0,4	KAT2A	MBD5	14534(Tax:10090)	109241(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice .
20110770	0	KAT3	71,75	CBP	86,89	KAT3	CBP	56267	1387	Gene	Gene	family|compound|START_ENTITY family|nmod|END_ENTITY	Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases .
24647121	0	KAT_II	57,63	kynurenine_aminotransferase_II	25,55	KAT II	kynurenine aminotransferase II	29416(Tax:10116)	29416(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A systemically-available kynurenine_aminotransferase_II -LRB- KAT_II -RRB- inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats .
20621975	0	KBP	0,3	SCG10	19,24	KBP	SCG10	606294(Tax:10116)	84510(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	KBP interacts with SCG10 , linking Goldberg-Shprintzen_syndrome to microtubule dynamics and neuronal differentiation .
22542517	0	KBTBD13	0,7	Cullin_3	23,31	KBTBD13	Cullin 3	390594	8452	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	KBTBD13 interacts with Cullin_3 to form a functional ubiquitin ligase .
9950760	0	KCC1	50,54	K-Cl_cotransporter	30,48	KCC1	K-Cl cotransporter	6560	6560	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of the K-Cl_cotransporter -LRB- KCC1 -RRB- with the Na-K-Cl_cotransporter in HEK-293 cells .
11325574	0	KCC3	58,62	SLC12A6	64,71	KCC3	SLC12A6	9990	9990	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Mutation analysis of the potassium_chloride cotransporter KCC3 -LRB- SLC12A6 -RRB- in rolandic and idiopathic_generalized_epilepsy .
16314831	0	KCMF1	15,20	CD99	42,46	KCMF1	CD99	56888	4267	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Suppression of KCMF1 by constitutive high CD99 expression is involved in the migratory ability of Ewing 's _ sarcoma cells .
25582440	0	KCMF1	0,5	UBR4	60,64	KCMF1	UBR4	56888	23352	Gene	Gene	Links|nsubj|START_ENTITY Links|dobj|END_ENTITY	KCMF1 -LRB- potassium_channel_modulatory_factor_1 -RRB- Links RAD6 to UBR4 -LRB- ubiquitin_N-recognin_domain-containing_E3_ligase_4 -RRB- and Lysosome-Mediated Degradation .
20018001	0	KCNB1	15,20	HLA-DRB1	66,74	KCNB1	HLA-DRB1	3745	3123	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of KCNB1 to rheumatoid_arthritis via interaction with HLA-DRB1 .
20962273	0	KCNE1	29,34	KCNQ1	21,26	KCNE1	KCNQ1	3753	3784	Gene	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Stoichiometry of the KCNQ1 - KCNE1 ion channel complex .
16266404	0	KCNE1	34,39	minK	41,45	KCNE1	minK	3753	3753	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Possible association of the human KCNE1 -LRB- minK -RRB- gene and QT interval in healthy subjects : evidence from association and linkage analyses in Israeli families .
19660109	0	KCNE1	44,49	minK	53,57	KCNE1	minK	3753	3753	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Positive selection at codon 38 of the human KCNE1 -LRB- = minK -RRB- gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes .
17161791	0	KCNE2	0,5	KCNQ1	26,31	KCNE2	KCNQ1	171138(Tax:10116)	84020(Tax:10116)	Gene	Gene	colocalized|nsubjpass|START_ENTITY colocalized|nmod|END_ENTITY	KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I -LRB- Ks -RRB- current amplitude in the heart .
12185453	0	KCNE2	58,63	MiRP1	65,70	KCNE2	MiRP1	9992	9992	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Identification and functional characterization of a novel KCNE2 -LRB- MiRP1 -RRB- mutation that alters HERG channel kinetics .
17335661	0	KCNE4	62,67	KCNQ1	14,19	KCNE4	KCNQ1	100773476	100761481	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Modulation of KCNQ1 current by atrial_fibrillation-associated KCNE4 -LRB- 145E/D -RRB- gene polymorphism .
10790218	0	KCNH2	22,27	HERG	28,32	KCNH2	HERG	3757	3757	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of the human KCNH2 -LRB- HERG -RRB- gene : identification and characterization of a novel mutation Y667X associated with long_QT_syndrome and a non-pathological 9 bp insertion .
12736144	0	KCNH2	27,32	HERG	34,38	KCNH2	HERG	3757	3757	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of KCNH2 -LRB- HERG -RRB- in the human jejunum .
19765650	0	KCNH2	37,42	HERG	31,35	KCNH2	HERG	3757	3757	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and significance of HERG -LRB- KCNH2 -RRB- potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration .
19859662	0	KCNH2	20,25	HERG	14,18	KCNH2	HERG	3757	3757	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HERG -LRB- KCNH2 -RRB- potassium channel surface expression by diacylglycerol .
12890647	0	KCNH8	48,53	Elk1	55,59	KCNH8	Elk1	131096	2002	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Distribution and functional properties of human KCNH8 -LRB- Elk1 -RRB- potassium channels .
24400161	0	KCNJ1	40,45	ROMK	66,70	KCNJ1	ROMK	447262(Tax:8355)	447262(Tax:8355)	Gene	Gene	mutations|nummod|START_ENTITY mutations|appos|END_ENTITY	Identification of compound heterozygous KCNJ1 mutations -LRB- encoding ROMK -RRB- in a kindred with Bartter 's _ syndrome and a functional analysis of their pathogenicity .
23902843	0	KCNJ11	8,14	ABCC8	1,6	KCNJ11	ABCC8	3767	6833	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- ABCC8 , KCNJ11 and GLUD1 gene mutation analysis in congenital_hyperinsulinism pedigree -RSB- .
19862325	0	KCNJ11	7,13	CDKAL1	15,21	KCNJ11	CDKAL1	3767	54901	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	PPARG , KCNJ11 , CDKAL1 , CDKN2A-CDKN2B , IDE-KIF11-HHEX , IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population .
22443257	0	KCNJ11	92,98	CDKAL1	78,84	KCNJ11	CDKAL1	3767	54901	Gene	Gene	TCF7L2|nummod|START_ENTITY TCF7L2|nummod|END_ENTITY	Polycystic_ovary_syndrome is not associated with polymorphisms of the TCF7L2 , CDKAL1 , HHEX , KCNJ11 , FTO and SLC30A8 genes .
20424228	0	KCNJ11	36,42	CDKN2A	67,73	KCNJ11	CDKN2A	3767	1029	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	KCNJ11	36,42	HHEX	61,65	KCNJ11	HHEX	3767	3087	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
19862325	0	KCNJ11	7,13	PPARG	0,5	KCNJ11	PPARG	3767	5468	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	PPARG , KCNJ11 , CDKAL1 , CDKN2A-CDKN2B , IDE-KIF11-HHEX , IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population .
20424228	0	KCNJ11	36,42	PPARG	29,34	KCNJ11	PPARG	3767	5468	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	KCNJ11	36,42	SLC30A8	52,59	KCNJ11	SLC30A8	3767	169026	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	KCNJ11	36,42	TCF7L2	44,50	KCNJ11	TCF7L2	3767	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20597906	0	KCNJ11	76,82	TCF7L2	62,68	KCNJ11	TCF7L2	3767	6934	Gene	Gene	HHEX|nummod|START_ENTITY HHEX|nummod|END_ENTITY	A validation study of type_2_diabetes-related variants of the TCF7L2 , HHEX , KCNJ11 , and ADIPOQ genes in one endogamous ethnic group of north India .
8088798	0	KCNJ3	76,81	GIRK1	63,68	KCNJ3	GIRK1	3760	3760	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Human G-protein-coupled inwardly rectifying potassium channel -LRB- GIRK1 -RRB- gene -LRB- KCNJ3 -RRB- : localization to chromosome 2 and identification of a simple tandem repeat polymorphism .
19756153	0	KCNJ6	20,25	GIRK2	27,32	KCNJ6	GIRK2	3763	3763	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between KCNJ6 -LRB- GIRK2 -RRB- gene polymorphisms and postoperative analgesic requirements after major abdominal surgery .
23994450	0	KCNJ6	21,26	GIRK2	28,33	KCNJ6	GIRK2	3763	3763	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations between KCNJ6 -LRB- GIRK2 -RRB- gene polymorphisms and pain-related phenotypes .
7796919	0	KCNJ6	78,83	inwardly-rectifying-K-channel	42,71	KCNJ6	inwardly-rectifying-K-channel	3763	3758	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization and variation of a human inwardly-rectifying-K-channel gene -LRB- KCNJ6 -RRB- : a putative ATP-sensitive K-channel subunit .
21680658	0	KCNK5	38,43	estrogen_receptor_alpha	58,81	KCNK5	estrogen receptor alpha	8645	2099	Gene	Gene	START_ENTITY|dep|induction induction|nmod|END_ENTITY	The two-pore domain potassium channel KCNK5 : induction by estrogen_receptor_alpha and role in proliferation of breast_cancer cells .
15178438	0	KCNK9	30,35	TASK-3	22,28	KCNK9	TASK-3	84429(Tax:10116)	84429(Tax:10116)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of TASK-3 -LRB- KCNK9 -RRB- to a subset of cortical neurons in the rat CNS .
23564779	0	KCNK9	78,83	TASK-3	85,91	KCNK9	TASK-3	51305	51305	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Expression and prognostic significance of the oncogenic K2P potassium channel KCNK9 -LRB- TASK-3 -RRB- in ovarian_carcinoma .
22114151	0	KCNMB1	38,44	Hypoxia-inducible_factor-1a	0,27	KCNMB1	Hypoxia-inducible factor-1a	3779	3091	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor-1a regulates KCNMB1 expression in human pulmonary artery smooth muscle cells .
10516439	0	KCNN1	115,120	SK1	105,108	KCNN1	SK1	3780	3780	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene -LRB- KCNN1 -RRB- .
23156743	0	KCNN2	67,72	SK2	62,65	KCNN2	SK2	3781	3781	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Construction and identification of the expression plasmid of SK2 -LRB- KCNN2 -RRB- gene from human atrial myocytes with overlapping PCR -RSB- .
24885636	0	KCNN4	112,117	PRL-3	101,106	KCNN4	PRL-3	3783	11156	Gene	Gene	manner|compound|START_ENTITY END_ENTITY|nmod|manner	Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner .
14998624	0	KCNQ1	109,114	HERG	67,71	KCNQ1	HERG	3784	3757	Gene	Gene	mutations|nummod|START_ENTITY END_ENTITY|nmod|mutations	Long_QT_syndrome in neonates : conduction_disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations .
20962273	0	KCNQ1	21,26	KCNE1	29,34	KCNQ1	KCNE1	3784	3753	Gene	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	Stoichiometry of the KCNQ1 - KCNE1 ion channel complex .
17161791	0	KCNQ1	26,31	KCNE2	0,5	KCNQ1	KCNE2	84020(Tax:10116)	171138(Tax:10116)	Gene	Gene	colocalized|nmod|START_ENTITY colocalized|nsubjpass|END_ENTITY	KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I -LRB- Ks -RRB- current amplitude in the heart .
17335661	0	KCNQ1	14,19	KCNE4	62,67	KCNQ1	KCNE4	100761481	100773476	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Modulation of KCNQ1 current by atrial_fibrillation-associated KCNE4 -LRB- 145E/D -RRB- gene polymorphism .
23977394	0	KCTD10	49,55	ETV1	36,40	KCTD10	ETV1	83892	2115	Gene	Gene	reveals|dobj|START_ENTITY reveals|nsubj|analysis analysis|nmod|END_ENTITY	Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal_stromal_tumor .
22810651	0	KCTD10	23,29	TNFAIP1	0,7	KCTD10	TNFAIP1	83892	7126	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-kB and AP-1 .
22810651	0	KCTD10	60,66	TNFAIP1	0,7	KCTD10	TNFAIP1	83892	7126	Gene	Gene	proteins|nummod|START_ENTITY degradation|nmod|proteins promote|dobj|degradation interacts|xcomp|promote interacts|nsubj|END_ENTITY	TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-kB and AP-1 .
19125419	0	KCTD10	0,6	proliferating_cell_nuclear_antigen	22,56	KCTD10	proliferating cell nuclear antigen	83892	5111	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	KCTD10 interacts with proliferating_cell_nuclear_antigen and its down-regulation could inhibit cell proliferation .
24156551	0	KCTD20	0,6	Akt	57,60	KCTD20	Akt	222658	207	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	KCTD20 , a relative of BTBD10 , is a positive regulator of Akt .
11747815	0	KChIP2	50,56	Kv_channel-interacting_protein_2	16,48	KChIP2	Kv channel-interacting protein 2	80906(Tax:10090)	80906(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A defect in the Kv_channel-interacting_protein_2 -LRB- KChIP2 -RRB- gene leads to a complete loss of I -LRB- to -RRB- and confers susceptibility to ventricular_tachycardia .
25580204	0	KDM1A	77,82	LSD1	71,75	KDM1A	LSD1	23028	23028	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	3,5-Diamino-1 ,2,4 - triazoles as a novel scaffold for potent , reversible LSD1 -LRB- KDM1A -RRB- inhibitors .
23400681	0	KDM1A	75,80	MiR-137	0,7	KDM1A	MiR-137	23028	406928	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A .
26682034	0	KDM2A	101,106	FBXL11	108,114	KDM2A	FBXL11	22992	22992	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A -LRB- FBXL11 -RRB- inhibitor .
25488809	0	KDM3A	31,36	estrogen_receptor	46,63	KDM3A	estrogen receptor	55818	2099	Gene	Gene	regulator|nsubj|START_ENTITY regulator|compound|END_ENTITY	The histone demethylase enzyme KDM3A is a key estrogen_receptor regulator in breast_cancer .
25413303	0	KDM3B	65,70	ANGPT1	30,36	KDM3B	ANGPT1	51780	284	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B .
25534856	0	KDM4B	24,29	MyoD	45,49	KDM4B	MyoD	193796(Tax:10090)	17927(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The histone demethylase KDM4B interacts with MyoD to regulate myogenic differentiation in C2C12 myoblast cells .
10825432	0	KDR	25,28	3G2	44,47	KDR	3G2	3791	10180	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Targeting of endothelial KDR receptors with 3G2 immunoliposomes in vitro .
10331422	0	KDR	67,70	Basic_fibroblast_growth_factor	0,30	KDR	Basic fibroblast growth factor	3791	2247	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces expression of VEGF receptor KDR through a protein_kinase_C and p44/p42 mitogen-activated protein kinase-dependent pathway .
19170841	0	KDR	18,21	CD34	12,16	KDR	CD34	3791	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Circulating CD34 + KDR + endothelial progenitor cells correlate with erectile function and endothelial function in overweight men .
19173675	0	KDR	18,21	CD34	12,16	KDR	CD34	3791	947	Gene	Gene	+|compound|START_ENTITY +|dep|Circulating Circulating|dobj|+ +|compound|END_ENTITY	Circulating CD34 + / KDR + endothelial progenitor cells are reduced in chronic_heart_failure patients as a function of Type_D personality .
21030714	0	KDR	12,15	CD34	54,58	KDR	CD34	3791	947	Gene	Gene	cells|compound|START_ENTITY generated|nsubjpass|cells generated|advcl|circulating circulating|dobj|cells cells|nummod|END_ENTITY	Human CD34 + / KDR + cells are generated from circulating CD34 + cells after immobilization on activated platelets .
21030714	0	KDR	12,15	CD34	6,10	KDR	CD34	3791	947	Gene	Gene	cells|compound|START_ENTITY generated|nsubjpass|cells +|parataxis|generated +|compound|END_ENTITY	Human CD34 + / KDR + cells are generated from circulating CD34 + cells after immobilization on activated platelets .
21543296	0	KDR	35,38	CD34	30,34	KDR	CD34	3791	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Endothelial progenitor cells -LRB- CD34 + KDR + -RRB- and monocytes may provide the development of good coronary collaterals despite the vascular risk factors and extensive atherosclerosis .
22805118	0	KDR	22,25	CD34	16,20	KDR	CD34	3791	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Mobilization of CD34 + KDR + endothelial progenitor cells predicts target_lesion revascularization .
22855739	0	KDR	34,37	CD34	28,32	KDR	CD34	3791	947	Gene	Gene	cells|dep|START_ENTITY END_ENTITY|dep|cells	Osteocalcin positive CD133 + / CD34 - / KDR + progenitor cells as an independent marker for unstable atherosclerosis .
23171577	0	KDR	36,39	CD34	30,34	KDR	CD34	3791	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Quantification of circulating CD34 + / KDR + / CD45dim endothelial progenitor cells : analytical considerations .
23383116	0	KDR	25,28	CD34	19,23	KDR	CD34	25589(Tax:10116)	305081(Tax:10116)	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Analysis of CD45 - -LSB- CD34 + / KDR + -RSB- endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic_stroke .
23895310	0	KDR	99,102	CD34	58,62	KDR	CD34	3791	947	Gene	Gene	platelets|dep|START_ENTITY platelets|acl:relcl|correlate correlate|nmod|mobilization mobilization|nmod|cells cells|compound|END_ENTITY	Activated platelets correlate with mobilization of na ve CD34 -LRB- + -RRB- cells and generation of CD34 -LRB- + -RRB- / KDR -LRB- + -RRB- cells in the circulation .
24365195	0	KDR	28,31	CD34	22,26	KDR	CD34	3791	947	Gene	Gene	cells|compound|START_ENTITY predict|nsubj|cells Levels|parataxis|predict Levels|acl|circulating circulating|dobj|+ +|compound|END_ENTITY	Levels of circulating CD34 + / KDR + cells do not predict coronary_in-stent_restenosis .
10864920	0	KDR	118,121	Flk-1	112,117	KDR	Flk-1	3791	3791	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Nuclear_factor-kappaB and cAMP_response_element_binding_protein mediate opposite transcriptional effects on the Flk-1 / KDR gene promoter .
15996656	0	KDR	115,118	Flk-1	109,114	KDR	Flk-1	407170(Tax:9913)	407170(Tax:9913)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	VEGF189 stimulates endothelial cells proliferation and migration in vitro and up-regulates the expression of Flk-1 / KDR mRNA .
16820800	0	KDR	40,43	Interleukin-6	0,13	KDR	Interleukin-6	3791	3569	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-6 upregulates expression of KDR and stimulates proliferation of human cerebrovascular smooth muscle cells .
22408460	0	KDR	79,82	Kinase_Insert_Domain_Receptor	48,77	KDR	Kinase Insert Domain Receptor	3791	3791	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Pyrrolo -LSB- 3,2-d -RSB- pyrimidine Derivatives as Type II Kinase_Insert_Domain_Receptor -LRB- KDR -RRB- Inhibitors : CoMFA and CoMSIA Studies .
21385572	0	KDR	38,41	MARCH-I	0,7	KDR	MARCH-I	3791	55016	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	MARCH-I expression in cord blood CD34 + KDR + cells .
16513643	0	KDR	180,183	NP-1	172,176	KDR	NP-1	3791	8829	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Characterization of a bicyclic peptide neuropilin-1 -LRB- NP-1 -RRB- antagonist -LRB- EG3287 -RRB- reveals importance of vascular_endothelial_growth_factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling .
25986862	0	KDR	27,30	PTK7	19,23	KDR	PTK7	3791	5754	Gene	Gene	activity|compound|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Biphasic effect of PTK7 on KDR activity in endothelial cells and angiogenesis .
10749680	0	KDR	107,110	Sck	33,36	KDR	Sck	3791	25759	Gene	Gene	forms|dobj|START_ENTITY forms|nsubj|protein protein|appos|END_ENTITY	The Shc-related adaptor protein , Sck , forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells .
9790910	0	KDR	19,22	Sck	0,3	KDR	Sck	3791	25759	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sck interacts with KDR and Flt-1 via its SH2 domain .
10066445	0	KDR	44,47	VEGF	0,4	KDR	VEGF	3791	7422	Gene	Gene	cells|compound|START_ENTITY translocation|nmod|cells induces|dobj|translocation induces|nsubj|END_ENTITY	VEGF induces nuclear translocation of Flk-1 / KDR , endothelial_nitric_oxide_synthase , and caveolin-1 in vascular endothelial cells .
10748050	0	KDR	39,42	VEGF	150,154	KDR	VEGF	3791	7422	Gene	Gene	modulation|nmod|START_ENTITY mRNAs|nsubj|modulation mRNAs|nmod|END_ENTITY	Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- receptor mRNAs by VEGF .
11348872	0	KDR	129,132	VEGF	0,4	KDR	VEGF	3791	7422	Gene	Gene	receptor|compound|START_ENTITY endothelial|nmod|receptor protects|xcomp|endothelial protects|nsubj|END_ENTITY	VEGF protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor .
11349728	0	KDR	48,51	VEGF	19,23	KDR	VEGF	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Gene expression of VEGF and its receptors Flk-1 / KDR and Flt-1 in cultured and transplanted rat islets .
12052848	0	KDR	0,3	VEGF	74,78	KDR	VEGF	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	mediator|nsubj|START_ENTITY mediator|nmod|effect effect|nmod|END_ENTITY	KDR -LRB- VEGF receptor 2 -RRB- is the major mediator for the hypotensive effect of VEGF .
12226078	0	KDR	76,79	VEGF	55,59	KDR	VEGF	407170(Tax:9913)	281572(Tax:9913)	Gene	Gene	involved|nsubjpass|START_ENTITY Transactivation|parataxis|involved Transactivation|nmod|Flk-1 Flk-1|amod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|dep|END_ENTITY	Transactivation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR is involved in sphingosine_1-phosphate-stimulated phosphorylation of Akt and endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- .
12665467	0	KDR	53,56	VEGF	14,18	KDR	VEGF	443087(Tax:9940)	443103(Tax:9940)	Gene	Gene	altered|nsubjpass|START_ENTITY Expression|parataxis|altered Expression|nmod|END_ENTITY	Expression of VEGF and its receptors Flt-1 and Flk-1 / KDR is altered in lambs with increased_pulmonary_blood_flow and pulmonary_hypertension .
12670961	0	KDR	120,123	VEGF	102,106	KDR	VEGF	3791	7422	Gene	Gene	phosphorylation|appos|START_ENTITY function|dobj|phosphorylation function|advmod|upstream upstream|nmod|factor factor|appos|END_ENTITY	Heterotrimeric G alpha q/G _ alpha_11 proteins function upstream of vascular endothelial growth factor -LRB- VEGF -RRB- receptor-2 -LRB- KDR -RRB- phosphorylation in vascular permeability factor/VEGF signaling .
12974081	0	KDR	41,44	VEGF	35,39	KDR	VEGF	3791	7422	Gene	Gene	MMP-1|appos|START_ENTITY MMP-1|compound|END_ENTITY	-LSB- Expression and significance about VEGF , KDR , MMP-1 , and transcription factor Ets-1 in human cervical_carcinoma -RSB- .
15124924	0	KDR	82,85	VEGF	49,53	KDR	VEGF	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|molecules molecules|nmod|expressions expressions|nmod|END_ENTITY	Regulatory molecules for coronary expressions of VEGF and its angiogenic receptor KDR in hypoestrogenic middle-aged female rats .
15262130	0	KDR	170,173	VEGF	153,157	KDR	VEGF	3791	7422	Gene	Gene	transducers|appos|START_ENTITY transducers|nmod|transcription transcription|nmod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- and ovarian_carcinoma cell supernatant activate signal transducers and activators of transcription -LRB- STATs -RRB- via VEGF receptor-2 -LRB- KDR -RRB- in human hemopoietic progenitor cells .
15262130	0	KDR	170,173	VEGF	36,40	KDR	VEGF	3791	7422	Gene	Gene	transducers|appos|START_ENTITY activate|dobj|transducers activate|nsubj|Vascular_endothelial_growth_factor Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- and ovarian_carcinoma cell supernatant activate signal transducers and activators of transcription -LRB- STATs -RRB- via VEGF receptor-2 -LRB- KDR -RRB- in human hemopoietic progenitor cells .
16010973	0	KDR	78,81	VEGF	45,49	KDR	VEGF	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|changes changes|nmod|expression expression|nmod|END_ENTITY	Age-related changes in cardiac expression of VEGF and its angiogenic receptor KDR in stroke-prone spontaneously hypertensive rats .
16394178	0	KDR	75,78	VEGF	100,104	KDR	VEGF	3791	7422	Gene	Gene	Flk-1|dobj|START_ENTITY Flk-1|nmod|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16394178	0	KDR	75,78	VEGF	54,58	KDR	VEGF	3791	7422	Gene	Gene	Flk-1|dobj|START_ENTITY Flk-1|nsubj|Regulation Regulation|nmod|receptor receptor|appos|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
17382929	0	KDR	18,21	VEGF	0,4	KDR	VEGF	3791	7422	Gene	Gene	internalization|appos|START_ENTITY internalization|compound|END_ENTITY	VEGF and VEGFR-2 -LRB- KDR -RRB- internalization is required for endothelial recovery during wound healing .
19244479	0	KDR	88,91	VEGF	27,31	KDR	VEGF	3791	7422	Gene	Gene	downregulation|nmod|START_ENTITY attenuates|nmod|downregulation attenuates|dobj|signaling signaling|compound|END_ENTITY	Chronic_hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells .
19356742	0	KDR	114,117	VEGF	99,103	KDR	VEGF	3791	7422	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Stimulatory effect of Cinnamomum cassia and cinnamic_acid on angiogenesis through up-regulation of VEGF and Flk-1 / KDR expression .
19520294	0	KDR	122,125	VEGF	47,51	KDR	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY peptide|nmod|gene exon|dobj|peptide exon|nsubj|Imaging Imaging|acl|targeted targeted|nmod|END_ENTITY	Imaging targeted at tumor with -LRB- 188 -RRB- Re-labeled VEGF -LRB- 189 -RRB- exon 6-encoded peptide and effects of the transfecting truncated KDR gene in tumor-bearing nude_mice .
23250775	0	KDR	155,158	VEGF	90,94	KDR	VEGF	3791	7422	Gene	Gene	follow-up|appos|START_ENTITY follow-up|nmod|analysis analysis|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
23393131	0	KDR	147,150	VEGF	99,103	KDR	VEGF	3791	7422	Gene	Gene	activation|appos|START_ENTITY activation|amod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|dep|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
7585655	0	KDR	75,78	VEGF	54,58	KDR	VEGF	3791	7422	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor gene , KDR , in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation .
7734144	0	KDR	23,26	VEGF	0,4	KDR	VEGF	3791	7422	Gene	Gene	show|nsubj|START_ENTITY subtypes|ccomp|show subtypes|nsubj|receptor receptor|compound|END_ENTITY	VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor .
9386990	0	KDR	79,82	VEGF	83,87	KDR	VEGF	3791	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor .
12453432	0	KDR	144,147	VEGFR-2	136,143	KDR	VEGFR-2	16542(Tax:10090)	16542(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2 / KDR expression .
10037737	0	KDR	44,47	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	3791	7422	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues .
10455194	0	KDR	118,121	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	3791	7422	Gene	Gene	activation|compound|START_ENTITY signals|nmod|activation signals|nsubj|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
10850461	0	KDR	35,38	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	3791	7422	Gene	Gene	activated|nsubj|START_ENTITY END_ENTITY|parataxis|activated	Vascular_endothelial_growth_factor / KDR activated microvessel density versus CD31 standard microvessel density in non-small_cell_lung_cancer .
11018037	0	KDR	93,96	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	407170(Tax:9913)	281572(Tax:9913)	Gene	Gene	connective_tissue_growth_factor|nmod|START_ENTITY expression|nmod|connective_tissue_growth_factor induces|dobj|expression induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces expression of connective_tissue_growth_factor via KDR , Flt1 , and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal_vascular_cells .
11058594	0	KDR	35,38	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	3791	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Vascular_endothelial_growth_factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells .
15262130	0	KDR	170,173	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	3791	7422	Gene	Gene	transducers|appos|START_ENTITY activate|dobj|transducers activate|nsubj|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- and ovarian_carcinoma cell supernatant activate signal transducers and activators of transcription -LRB- STATs -RRB- via VEGF receptor-2 -LRB- KDR -RRB- in human hemopoietic progenitor cells .
18164591	0	KDR	113,116	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	3791	7422	Gene	Gene	regulation|nmod|START_ENTITY expression|nmod|regulation regulates|dobj|expression regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast_growth_factor-2 .
20367253	0	KDR	66,69	Vascular_endothelial_growth_factor	0,34	KDR	Vascular endothelial growth factor	3791	7422	Gene	Gene	receptor|appos|START_ENTITY insult|dep|receptor fetal_liver_kinase_1|dep|insult fetal_liver_kinase_1|compound|END_ENTITY	Vascular_endothelial_growth_factor / kinase insult domain receptor -LRB- KDR -RRB- / fetal_liver_kinase_1 -LRB- FLK1 -RRB- - mediated skin-epithelial progenitor cells reprogramming .
23164459	0	KDR	52,55	Vascular_endothelial_growth_factor_receptor_2	0,45	KDR	Vascular endothelial growth factor receptor 2	3791	3791	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Vascular_endothelial_growth_factor_receptor_2 gene -LRB- KDR -RRB- polymorphisms and expression levels in depressive_disorder .
10455194	0	KDR	118,121	c-Src	136,141	KDR	c-Src	3791	6714	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
10455194	0	KDR	118,121	flk-1	112,117	KDR	flk-1	3791	3791	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
11098056	0	KDR	67,70	flk-1	61,66	KDR	flk-1	3791	3791	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Transforming_growth_factor-beta_1-mediated inhibition of the flk-1 / KDR gene is mediated by a 5 ' - untranslated region palindromic GATA site .
23158831	0	KDR	57,60	kinase_insert_domain-containing_receptor	15,55	KDR	kinase insert domain-containing receptor	3791	3791	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of kinase_insert_domain-containing_receptor -LRB- KDR -RRB- gene polymorphisms with idiopathic recurrent_spontaneous_abortion in Korean women .
21695506	0	KDR	148,151	kinase_insert_domain_receptor	117,146	KDR	kinase insert domain receptor	3791	3791	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Molecular docking and 3D-QSAR study on 4 - -LRB- 1H-indazol-4-yl -RRB- phenylamino and aminopyrazolopyridine_urea derivatives as kinase_insert_domain_receptor -LRB- KDR -RRB- inhibitors .
23393131	0	KDR	147,150	kinase_insert_domain_receptor	116,145	KDR	kinase insert domain receptor	3791	3791	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
26634469	0	KDR	42,45	kinase_insert_domain_receptor	11,40	KDR	kinase insert domain receptor	3791	3791	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of kinase_insert_domain_receptor -LRB- KDR -RRB- gene silencing on the sensitivity of A549 cells to erlotinib .
10799512	0	KDR	62,65	vascular_endothelial_growth_factor	97,131	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	region|nmod|START_ENTITY residues|nmod|region Identification|nmod|residues Identification|amod|important important|nmod|interaction interaction|nmod|antibodies antibodies|compound|END_ENTITY	Identification of the residues in the extracellular region of KDR important for interaction with vascular_endothelial_growth_factor and neutralizing anti-KDR antibodies .
12135291	0	KDR	87,90	vascular_endothelial_growth_factor	18,52	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of vascular_endothelial_growth_factor and its endothelial cell receptor KDR in type 1 leprosy reaction .
12226078	0	KDR	76,79	vascular_endothelial_growth_factor	19,53	KDR	vascular endothelial growth factor	407170(Tax:9913)	281572(Tax:9913)	Gene	Gene	involved|nsubjpass|START_ENTITY Transactivation|parataxis|involved Transactivation|nmod|Flk-1 Flk-1|amod|END_ENTITY	Transactivation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR is involved in sphingosine_1-phosphate-stimulated phosphorylation of Akt and endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- .
12439912	0	KDR	67,70	vascular_endothelial_growth_factor	14,48	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptors KDR and Flt-1 in gastric_cancer cells .
12859876	0	KDR	68,71	vascular_endothelial_growth_factor	15,49	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of vascular_endothelial_growth_factor and its receptors KDR and Flt1 in acute_myeloid_leukemia -RSB- .
15946674	0	KDR	157,160	vascular_endothelial_growth_factor	102,136	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	receptor-2|appos|START_ENTITY receptor-2|compound|END_ENTITY	Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular_endothelial_growth_factor receptor-2 -LRB- VEGFR-2 / KDR -RRB- .
16210956	0	KDR	77,80	vascular_endothelial_growth_factor	16,50	KDR	vascular endothelial growth factor	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	Function|dep|START_ENTITY Function|nmod|receptors receptors|compound|END_ENTITY	Function of the vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 / KDR in the alloimmune response in vivo .
16394178	0	KDR	75,78	vascular_endothelial_growth_factor	18,52	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	Flk-1|dobj|START_ENTITY Flk-1|nsubj|Regulation Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16556453	0	KDR	70,73	vascular_endothelial_growth_factor	12,46	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor and its receptor Flk-1 / KDR in promoting tumour angiogenesis in feline and canine mammary carcinomas : a preliminary study of autocrine and paracrine loops .
18763120	0	KDR	68,71	vascular_endothelial_growth_factor	16,50	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|Coexpression Coexpression|nmod|END_ENTITY	Coexpression of vascular_endothelial_growth_factor and its receptor KDR on gastric_adenocarcinoma MGC803 cell line and stimulation of exogenous VEGF -LRB- 165 -RRB- to MGC803 cells .
19218116	0	KDR	73,76	vascular_endothelial_growth_factor	15,49	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of vascular_endothelial_growth_factor and its receptor Flk-1 / KDR in benign and malignant_breast_neoplasms -RSB- .
20538805	0	KDR	62,65	vascular_endothelial_growth_factor	10,44	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of vascular_endothelial_growth_factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo .
23250775	0	KDR	155,158	vascular_endothelial_growth_factor	54,88	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	follow-up|appos|START_ENTITY follow-up|nmod|analysis analysis|nmod|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
23393131	0	KDR	147,150	vascular_endothelial_growth_factor	63,97	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
7585655	0	KDR	75,78	vascular_endothelial_growth_factor	18,52	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor gene , KDR , in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation .
7664263	0	KDR	67,70	vascular_endothelial_growth_factor	14,48	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor , KDR , correlates with vascularity , metastasis , and proliferation of human colon_cancer .
7929268	1	KDR	162,165	vascular_endothelial_growth_factor	40,74	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|dep|Potentiation Potentiation|nmod|bioactivity bioactivity|compound|END_ENTITY	Potentiation of vascular_endothelial_growth_factor bioactivity , in vitro and in vivo , and high affinity binding to Flt-1 but not to Flk-1 / KDR .
7929439	0	KDR	44,47	vascular_endothelial_growth_factor	76,110	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	properties|nmod|START_ENTITY properties|appos|receptors receptors|nmod|END_ENTITY	Different signal transduction properties of KDR and Flt1 , two receptors for vascular_endothelial_growth_factor .
8621427	0	KDR	78,81	vascular_endothelial_growth_factor	18,52	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	determinants|nmod|START_ENTITY determinants|nsubj|Identification Identification|nmod|END_ENTITY	Identification of vascular_endothelial_growth_factor determinants for binding KDR and FLT-1 receptors .
8806634	0	KDR	132,135	vascular_endothelial_growth_factor	48,82	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|form form|nmod|receptor receptor|compound|END_ENTITY	Identification of a natural soluble form of the vascular_endothelial_growth_factor receptor , FLT-1 , and its heterodimerization with KDR .
8840857	0	KDR	75,78	vascular_endothelial_growth_factor	31,65	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|upregulation upregulation|nmod|receptor receptor|compound|END_ENTITY	Functional upregulation of the vascular_endothelial_growth_factor receptor KDR by hypoxia .
9732240	0	KDR	58,61	vascular_endothelial_growth_factor	14,48	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor receptor KDR in vitro by a soluble factor in confluent endothelial cells .
9846628	0	KDR	67,70	vascular_endothelial_growth_factor	14,48	KDR	vascular endothelial growth factor	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor , KDR , following retinal_ischemia-reperfusion injury in the rat .
9889193	0	KDR	127,130	vascular_endothelial_growth_factor	8,42	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	VEGFR-2|appos|START_ENTITY signalling|nmod|VEGFR-2 angiogenesis|acl|signalling Orf_virus|appos|angiogenesis encoded|nmod|Orf_virus encoded|nsubj|END_ENTITY	A novel vascular_endothelial_growth_factor encoded by Orf_virus , VEGF-E , mediates angiogenesis via signalling through VEGFR-2 -LRB- KDR -RRB- but not VEGFR-1 -LRB- Flt-1 -RRB- receptor tyrosine kinases .
9892193	0	KDR	101,104	vascular_endothelial_growth_factor	50,84	KDR	vascular endothelial growth factor	3791	7422	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|nmod|receptor receptor|compound|END_ENTITY	SU5416 is a potent and selective inhibitor of the vascular_endothelial_growth_factor receptor -LRB- Flk-1 / KDR -RRB- that inhibits tyrosine kinase catalysis , tumor vascularization , and growth of multiple tumor types .
26980696	0	KEAP1	35,40	MBD1	0,4	KEAP1	MBD1	9817	4152	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MBD1 is an epigenetic regulator of KEAP1 in pancreatic_cancer .
20061377	0	KEAP1	59,64	NRF2	14,18	KEAP1	NRF2	9817	4780	Gene	Gene	formation|nummod|START_ENTITY involves|dobj|formation involves|nsubj|Activation Activation|nmod|END_ENTITY	Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation .
21357422	0	KEAP1	51,56	NRF2	41,45	KEAP1	NRF2	9817	4780	Gene	Gene	mechanism|compound|START_ENTITY activate|nmod|mechanism activate|dobj|END_ENTITY	Electrophilic nitro-fatty_acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism .
22215675	0	KEAP1	107,112	NRF2	63,67	KEAP1	NRF2	9817	4780	Gene	Gene	protein|compound|START_ENTITY competitive|nmod|protein inhibits|nmod|competitive inhibits|dobj|degradation degradation|nmod|protein protein|compound|END_ENTITY	Wilms_tumor gene on X chromosome -LRB- WTX -RRB- inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein .
22331464	0	KEAP1	21,26	NRF2	38,42	KEAP1	NRF2	9817	4780	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|promote promote|dobj|accumulation accumulation|amod|END_ENTITY	PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function .
23382044	0	KEAP1	39,44	NRF2	86,90	KEAP1	NRF2	9817	4780	Gene	Gene	analysis|nmod|START_ENTITY reveals|nsubj|analysis reveals|dobj|proteins proteins|acl:relcl|inhibit inhibit|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination .
24322982	0	KEAP1	28,33	NRF2	41,45	KEAP1	NRF2	9817	4780	Gene	Gene	mutations|nmod|START_ENTITY impair|nsubj|mutations impair|dobj|degradation degradation|compound|END_ENTITY	Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination .
25793262	0	KEAP1	73,78	NRF2	80,84	KEAP1	NRF2	9817	4780	Gene	Gene	Activation|compound|START_ENTITY Activation|appos|END_ENTITY	Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1 , NRF2 Activation , and Glutathione Depletion In Vitro .
26301506	0	KEAP1	84,89	NRF2	76,80	KEAP1	NRF2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	Deletion|compound|START_ENTITY Affected|nmod|Deletion Affected|nmod|Activation Activation|nmod|END_ENTITY	Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid , RTA_405 .
22331464	0	KEAP1	21,26	PALB2	0,5	KEAP1	PALB2	9817	79728	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function .
22684020	0	KEAP1	19,24	PPARy	37,42	KEAP1	PPARy	9817	5468	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	Regulatory role of KEAP1 and NRF2 in PPARy expression and chemoresistance in human non-small-cell_lung_carcinoma cells .
19819304	0	KEPI	10,14	Ppp1r14c	16,24	KEPI	Ppp1r14c	76142(Tax:10090)	76142(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of KEPI -LRB- Ppp1r14c -RRB- deletion on morphine analgesia and tolerance in mice of different genetic backgrounds : when a knockout is near a relevant quantitative trait locus .
17699606	0	KGB-1	66,71	GLH-1	0,5	KGB-1	GLH-1	176866(Tax:6239)	172414(Tax:6239)	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	GLH-1 , the C. _ elegans P granule protein , is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5 .
26508592	0	KGF	28,31	FGF7	22,26	KGF	FGF7	2252	2252	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of FGF7 -LRB- KGF -RRB- in the regenerating tail of lizard suggests it is involved in the differentiation of the epidermis .
10873663	0	KGF	69,72	keratinocyte_growth_factor	35,61	KGF	keratinocyte growth factor	2252	2252	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Vitamin_D induced up-regulation of keratinocyte_growth_factor -LRB- FGF-7 / KGF -RRB- in MCF-7 human breast_cancer cells .
1696274	0	KGF	142,145	keratinocyte_growth_factor	6,32	KGF	keratinocyte growth factor	2252	2252	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Human keratinocyte_growth_factor activity on proliferation and differentiation of human keratinocytes : differentiation response distinguishes KGF from EGF family .
20213138	0	KGF	73,76	keratinocyte_growth_factor	45,71	KGF	keratinocyte growth factor	2252	2252	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of tumour-cell-derived or recombinant keratinocyte_growth_factor -LRB- KGF -RRB- on proliferation and radioresponse of human epithelial_tumour cells -LRB- HNSCC -RRB- and normal keratinocytes in vitro .
9430821	0	KGF	51,54	keratinocyte_growth_factor	23,49	KGF	keratinocyte growth factor	403915(Tax:9615)	403915(Tax:9615)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Differential effect of keratinocyte_growth_factor -LRB- KGF -RRB- on aromatase activity in cultured canine prostatic epithelial cells .
9614385	0	KGF	39,42	keratinocyte_growth_factor	11,37	KGF	keratinocyte growth factor	29348(Tax:10116)	29348(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of keratinocyte_growth_factor -LRB- KGF -RRB- on gut growth and repair .
20815256	0	KGF2	47,51	keratinocyte_growth_factor_2	12,40	KGF2	keratinocyte growth factor 2	2255	2255	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Cloning of keratinocyte_growth_factor_2 gene -LRB- KGF2 -RRB- and its transformation to Brassica_napus_L -RSB- .
21725612	0	KHDRBS3	24,31	SerpinB5	0,8	KHDRBS3	SerpinB5	10656	5268	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric_cancer cells .
26521124	0	KHK	144,147	ketohexokinase	128,142	KHK	ketohexokinase	3795	3795	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Pharmacophore modeling , virtual screening , molecular docking studies and density functional theory approaches to identify novel ketohexokinase -LRB- KHK -RRB- inhibitors .
21673012	0	KIAA0101	0,8	BRCA1	24,29	KIAA0101	BRCA1	9768	672	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	KIAA0101 interacts with BRCA1 and regulates centrosome number .
23455931	0	KIAA0196	70,78	SPG8	80,84	KIAA0196	SPG8	9897	9897	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pure adult-onset spastic_paraplegia caused by a novel mutation in the KIAA0196 -LRB- SPG8 -RRB- gene .
19419997	0	KIAA0319	32,40	adaptor_protein_2	56,73	KIAA0319	adaptor protein 2	9856	7020	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The dyslexia-associated protein KIAA0319 interacts with adaptor_protein_2 and follows the classical clathrin-mediated endocytosis pathway .
19144723	0	KIAA0586	18,26	Talpid3	4,11	KIAA0586	Talpid3	423540(Tax:9031)	423540(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Talpid3 gene -LRB- KIAA0586 -RRB- encodes a centrosomal protein that is essential for primary cilia formation .
26386044	0	KIAA0586	54,62	talpid3	40,47	KIAA0586	talpid3	423540(Tax:9031)	423540(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in human homologue of chicken talpid3 gene -LRB- KIAA0586 -RRB- cause a hybrid ciliopathy with overlapping features of Jeune and Joubert_syndromes .
19338451	0	KIAA1217	51,59	SKT	41,44	KIAA1217	SKT	56243	56243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the tag SNPs in the human SKT gene -LRB- KIAA1217 -RRB- with lumbar_disc_herniation .
25382612	0	KIAA1549	0,8	BRAF	9,13	KIAA1549	BRAF	57670	673	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	KIAA1549 : BRAF fusion gene in pediatric brain_tumors of various histogenesis .
26083571	0	KIAA1549	0,8	BRAF	10,14	KIAA1549	BRAF	57670	673	Gene	Gene	START_ENTITY|dep|Fusion Fusion|compound|END_ENTITY	KIAA1549 : BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic_Astrocytomas .
20084082	0	KIAA1718	37,45	FGF4	95,99	KIAA1718	FGF4	338523(Tax:10090)	2249	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Dual-specificity histone demethylase KIAA1718 -LRB- KDM7A -RRB- regulates neural differentiation through FGF4 .
23224238	0	KIDARI	32,38	HFR1	60,64	KIDARI	HFR1	839585(Tax:3702)	839300(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	A competitive peptide inhibitor KIDARI negatively regulates HFR1 by forming nonfunctional heterodimers in Arabidopsis photomorphogenesis .
26245936	0	KIF1-binding_protein	0,20	KIF3A	36,41	KIF1-binding protein	KIF3A	72320(Tax:10090)	16568(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	KIF1-binding_protein interacts with KIF3A in haploid male germ cells .
26245936	0	KIF1-binding_protein	0,20	KIF3A	36,41	KIF1-binding protein	KIF3A	72320(Tax:10090)	16568(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	KIF1-binding_protein interacts with KIF3A in haploid male germ cells .
15923660	0	KIF13B	63,69	Centaurin-alpha1	0,16	KIF13B	Centaurin-alpha1	305967(Tax:10116)	171097(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B .
23077056	0	KIF13B	110,116	Cyclin-dependent_kinase_5	0,25	KIF13B	Cyclin-dependent kinase 5	23303	1020	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B .
25106407	0	KIF14	73,78	Sox17	0,5	KIF14	Sox17	9928	64321	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression inhibits|nmod|downregulation inhibits|nsubj|END_ENTITY	Sox17 inhibits hepatocellular_carcinoma progression by downregulation of KIF14 expression .
19190782	0	KIF14	0,5	retinoblastoma	40,54	KIF14	retinoblastoma	9928	5925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association .
26823018	0	KIF17	32,37	Septin_9	0,8	KIF17	Septin 9	500571(Tax:10116)	83788(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Septin_9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport .
17196196	0	KIF17b	98,104	Spatial	24,31	KIF17b	Spatial	16559(Tax:10090)	65971(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Dynamic distribution of Spatial during mouse spermatogenesis and its interaction with the kinesin KIF17b .
22258533	0	KIF1A	0,5	SPG30	28,33	KIF1A	SPG30	547	547	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	KIF1A missense mutations in SPG30 , an autosomal_recessive_spastic_paraplegia : distinct phenotypes according to the nature of the mutations .
25353516	0	KIF1A	93,98	microtubule-associated_protein_tau	14,48	KIF1A	microtubule-associated protein tau	547	4137	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the microtubule-associated_protein_tau on dynamics of single-headed motor proteins KIF1A .
25961928	0	KIF20A	37,43	FOXM1	19,24	KIF20A	FOXM1	10112	2305	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|xcomp|regulate	Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast_cancer paclitaxel resistance .
25961928	0	KIF20A	37,43	FOXM1	19,24	KIF20A	FOXM1	10112	2305	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|xcomp|regulate	Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast_cancer paclitaxel resistance .
23864681	0	KIF20B	30,36	Shootin1	0,8	KIF20B	Shootin1	240641(Tax:10090)	71653(Tax:10090)	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons .
24426772	0	KIF21A	58,64	kinesin_family_member_21A	31,56	KIF21A	kinesin family member 21A	55605	55605	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Maternal germline mosaicism of kinesin_family_member_21A -LRB- KIF21A -RRB- mutation causes complex phenotypes in a Chinese family with congenital fibrosis of the extraocular muscles .
16298999	0	KIF3	38,42	kinesin-2	12,21	KIF3	kinesin-2	16568(Tax:10090)	16563(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Role of the kinesin-2 family protein , KIF3 , during mitosis .
26127003	0	KIF3A	15,20	ACTL9	40,45	KIF3A	ACTL9	11127	284382	Gene	Gene	Correlation|nmod|START_ENTITY END_ENTITY|nsubj|Correlation	Correlation of KIF3A and OVOL1 , but not ACTL9 , with atopic_dermatitis in Chinese pediatric patients .
26127003	0	KIF3A	15,20	ACTL9	40,45	KIF3A	ACTL9	11127	284382	Gene	Gene	Correlation|nmod|START_ENTITY END_ENTITY|nsubj|Correlation	Correlation of KIF3A and OVOL1 , but not ACTL9 , with atopic_dermatitis in Chinese pediatric patients .
26245936	0	KIF3A	36,41	KIF1-binding_protein	0,20	KIF3A	KIF1-binding protein	16568(Tax:10090)	72320(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	KIF1-binding_protein interacts with KIF3A in haploid male germ cells .
26245936	0	KIF3A	36,41	KIF1-binding_protein	0,20	KIF3A	KIF1-binding protein	16568(Tax:10090)	72320(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	KIF1-binding_protein interacts with KIF3A in haploid male germ cells .
25878107	0	KIF3A	51,56	US3	23,26	KIF3A	US3	11127	2703401(Tax:10298)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Herpes_simplex_virus-1 US3 phosphorylates cellular KIF3A to down-regulate CD1d expression .
25878107	0	KIF3A	51,56	US3	23,26	KIF3A	US3	11127	2703401(Tax:10298)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Herpes_simplex_virus-1 US3 phosphorylates cellular KIF3A to down-regulate CD1d expression .
15297875	0	KIF4	19,23	PRC1	48,52	KIF4	PRC1	24137	9055	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation .
19451621	0	KIFAP3	56,62	Kinesin-Associated_Protein_3	26,54	KIFAP3	Kinesin-Associated Protein 3	22920	22920	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Reduced expression of the Kinesin-Associated_Protein_3 -LRB- KIFAP3 -RRB- gene increases survival in sporadic amyotrophic_lateral_sclerosis .
26843789	0	KIFAP3	48,54	Kinesin_Associated_Protein_3	18,46	KIFAP3	Kinesin Associated Protein 3	22920	22920	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Kinesin_Associated_Protein_3 -LRB- KIFAP3 -RRB- in Breast_Cancer .
16638812	0	KIFC5A	14,20	Nubp1	36,41	KIFC5A	Nubp1	16580(Tax:10090)	26425(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Motor protein KIFC5A interacts with Nubp1 and Nubp2 , and is implicated in the regulation of centrosome duplication .
11139340	0	KILLER/DR5	32,42	TRAIL	43,48	KILLER/DR5	TRAIL	8795	8743	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma .
9372844	0	KIP	70,73	DNA-dependent_protein_kinase	20,48	KIP	DNA-dependent protein kinase	23991(Tax:10090)	19090(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between DNA-dependent_protein_kinase and a novel protein , KIP .
10585280	0	KIP1	108,112	INK4	94,98	KIP1	INK4	1027	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16 -LRB- INK4 -RRB- and p27 -LRB- KIP1 -RRB- to CDKs , loss of E2F-binding activity , and premature senescence of human melanocytes .
11307151	0	KIP1	18,22	P27	14,17	KIP1	P27	1027	3429	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of P27 -LRB- KIP1 -RRB- is prognostic and independent of MYCN amplification in human neuroblastoma .
11250155	0	KIP1	76,80	SKP2	118,122	KIP1	SKP2	1027	6502	Gene	Gene	p27|appos|START_ENTITY degradation|nmod|p27 regulates|dobj|degradation regulates|nmod|SCF SCF|appos|END_ENTITY	PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27 -LRB- KIP1 -RRB- through the ubiquitin E3 ligase SCF -LRB- SKP2 -RRB- .
12586749	0	KIP1	108,112	SKP2	32,36	KIP1	SKP2	1027	6502	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Inhibition of F-Box protein p45 -LRB- SKP2 -RRB- expression and stabilization of cyclin-dependent kinase inhibitor p27 -LRB- KIP1 -RRB- in vitamin_D analog-treated cancer cells .
16988944	0	KIP1	45,49	SKP2	68,72	KIP1	SKP2	1027	6502	Gene	Gene	p27|appos|START_ENTITY Downregulation|nmod|p27 Downregulation|nmod|END_ENTITY	Downregulation of the KIP family members p27 -LRB- KIP1 -RRB- and p57 -LRB- KIP2 -RRB- by SKP2 and the role of methylation in p57 -LRB- KIP2 -RRB- inactivation in nonsmall_cell_lung_cancer .
17438373	0	KIP1	61,65	SKP2	18,22	KIP1	SKP2	1027	6502	Gene	Gene	assembly|appos|START_ENTITY proteolysis|nsubj|assembly E3|ccomp|proteolysis E3|nsubj|Regulation Regulation|nmod|ubiquitin ubiquitin|appos|END_ENTITY	Regulation of SCF -LRB- SKP2 -RRB- ubiquitin E3 ligase assembly and p27 -LRB- KIP1 -RRB- proteolysis by the PTEN pathway and cyclin_D1 .
21245140	0	KIP1	69,73	SKP2	83,87	KIP1	SKP2	1027	6502	Gene	Gene	p27|appos|START_ENTITY MYC|dobj|p27 MYC|nmod|END_ENTITY	SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27 -LRB- KIP1 -RRB- through SKP2 in human leukemia cells .
22372491	0	KIP1	46,50	SKP2	27,31	KIP1	SKP2	1027	6502	Gene	Gene	stabilization|appos|START_ENTITY induce|dobj|stabilization END_ENTITY|xcomp|induce	Prodigiosin down-regulates SKP2 to induce p27 -LRB- KIP1 -RRB- stabilization and antiproliferation in human lung_adenocarcinoma cells .
25070589	0	KIP1	50,54	SKP2	28,32	KIP1	SKP2	1027	6502	Gene	Gene	p27|appos|START_ENTITY stabilize|dobj|p27 END_ENTITY|xcomp|stabilize	Sulforaphane down-regulates SKP2 to stabilize p27 -LRB- KIP1 -RRB- for inducing antiproliferation in human colon_adenocarcinoma cells .
11818378	0	KIP1	19,23	Skp2	40,44	KIP1	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	p27|appos|START_ENTITY Involvement|nmod|p27 degradation|nsubj|Involvement degradation|nmod|END_ENTITY	Involvement of p27 -LRB- KIP1 -RRB- degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium .
14707456	0	KIP1	71,75	Skp2	0,4	KIP1	Skp2	1027	6502	Gene	Gene	p27|appos|START_ENTITY expression|nmod|p27 associated|nmod|expression associated|nsubjpass|END_ENTITY	Skp2 and Jab1 expression are associated with inverse expression of p27 -LRB- KIP1 -RRB- and poor prognosis in oral_squamous_cell_carcinomas .
14734747	0	KIP1	58,62	Skp2	113,117	KIP1	Skp2	1027	6502	Gene	Gene	p27|appos|START_ENTITY regulation|dep|p27 regulation|dep|arrest arrest|acl|mediated mediated|nmod|inhibition inhibition|nmod|transcription transcription|amod|END_ENTITY	Nuclear pro-IL-16 regulation of T cell proliferation : p27 -LRB- KIP1 -RRB- - dependent G0/G1 arrest mediated by inhibition of Skp2 transcription .
23339869	0	KIP1	20,24	TRIP6	0,5	KIP1	TRIP6	1027	7205	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TRIP6 regulates p27 KIP1 to promote tumorigenesis .
16465393	0	KIP1	27,31	cdc2	14,18	KIP1	cdc2	1027	983	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of cdc2 and p27 -LRB- KIP1 -RRB- phosphorylation in mitotic cells of the human retinoblastoma .
16075224	0	KIP1	65,69	extracellular_signal-regulated_kinase	19,56	KIP1	extracellular signal-regulated kinase	12576(Tax:10090)	26413(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of extracellular_signal-regulated_kinase and p27 -LRB- KIP1 -RRB- after retinal_detachment .
10454569	0	KIP1	86,90	p27	82,85	KIP1	p27	1027	3429	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Elevated cyclin E levels , inactive retinoblastoma protein , and suppression of the p27 -LRB- KIP1 -RRB- inhibitor characterize early development of promyeloid cells into macrophages .
10469613	0	KIP1	44,48	p27	40,43	KIP1	p27	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of the CDK inhibitor p27 -LRB- KIP1 -RRB- in rat two-stage bladder_carcinogenesis and its association with expression profiles of p21 -LRB- WAF1/Cip1 -RRB- and p53 .
10469613	4	KIP1	753,757	p27	749,752	KIP1	p27	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	In a rat two-stage urinary_bladder_carcinogenesis model , with N-butyl-N - -LRB- 4-hydroxybutyl -RRB- nitrosamine -LRB- BBN -RRB- initiation followed by promotion with sodium_L-ascorbate -LRB- Na-AsA -RRB- , we evaluated the expression of p27 -LRB- KIP1 -RRB- protein using immunohistochemistry during various stages of urinary_bladder_carcinogenesis .
10702262	0	KIP1	131,135	p27	127,130	KIP1	p27	1027	3429	Gene	Gene	independent|appos|START_ENTITY independent|amod|END_ENTITY	Reversible G -LRB- 1 -RRB- arrest induced by inhibition of the epidermal_growth_factor_receptor tyrosine kinase requires up-regulation of p27 -LRB- KIP1 -RRB- independent of MAPK activity .
10704940	0	KIP1	44,48	p27	40,43	KIP1	p27	1027	3429	Gene	Gene	increase|appos|START_ENTITY increase|amod|END_ENTITY	Induction of G -LRB- 1 -RRB- cell cycle arrest and p27 -LRB- KIP1 -RRB- increase by panaxydol isolated from Panax_ginseng .
10705242	0	KIP1	12,16	p27	8,11	KIP1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of p27 -LRB- KIP1 -RRB- expression predicts poor prognosis in patients with esophageal_squamous_cell_carcinoma .
11093779	0	KIP1	17,21	p27	13,16	KIP1	p27	1027	10671	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of p27 -LRB- KIP1 -RRB- as a mechanism underlying NS398-induced growth inhibition in human lung_cancer cells .
11093779	11	KIP1	1598,1602	p27	1594,1597	KIP1	p27	1027	10671	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Metabolic labeling experiments showed that the synthesis rate of p27 -LRB- KIP1 -RRB- protein was not altered by NS398 .
11141482	0	KIP1	27,31	p27	23,26	KIP1	p27	1027	10671	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Protective function of p27 -LRB- KIP1 -RRB- against apoptosis in small_cell_lung_cancer cells in unfavorable microenvironments .
11340156	0	KIP1	20,24	p27	16,19	KIP1	p27	1027	10671	Gene	Gene	Requirement|appos|START_ENTITY Requirement|nmod|END_ENTITY	Requirement for p27 -LRB- KIP1 -RRB- in retinoblastoma protein-mediated senescence .
11819639	0	KIP1	22,26	p27	18,21	KIP1	p27	1027	3429	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of p27 -LRB- KIP1 -RRB- induced cell cycle arrest in G -LRB- 1 -RRB- phase and subsequent apoptosis in HCC-9204 cell line .
12429803	0	KIP1	150,154	p27	146,149	KIP1	p27	1027	10671	Gene	Gene	down-regulation|appos|START_ENTITY down-regulation|compound|END_ENTITY	Over-expression of p45 -LRB- SKP2 -RRB- in Kaposi 's _ sarcoma correlates with higher_tumor stage and extracutaneous involvement but is not directly related to p27 -LRB- KIP1 -RRB- down-regulation .
12586749	4	KIP1	825,829	p27	821,824	SKP2	p45	6502	6502	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Here , we show that treatment of AT-84 head and neck squamous_carcinoma cells with the 1,25 -LRB- OH -RRB- -LRB- 2 -RRB- D -LRB- 3 -RRB- analog EB1089 increases p27 -LRB- KIP1 -RRB- protein levels without significantly affecting expression of its mRNA .
15007644	0	KIP1	19,23	p27	15,18	KIP1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p27 -LRB- KIP1 -RRB- in proliferation of the retinal pigment epithelium and ciliary body .
16407831	0	KIP1	90,94	p27	86,89	KIP1	p27	1027	3429	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27 -LRB- KIP1 -RRB- protein .
16437650	0	KIP1	14,18	p27	10,13	KIP1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of p27 -LRB- KIP1 -RRB- on cell cycle and apoptosis in gastric_cancer cells .
16603463	0	KIP1	23,27	p27	19,22	KIP1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of p27 -LRB- KIP1 -RRB- in the mitotic cells of the corneal epithelium .
17854759	0	KIP1	60,64	p27	56,59	KIP1	p27	1027	10671	Gene	Gene	activity|appos|START_ENTITY activity|acl:relcl|cleaves cleaves|dobj|END_ENTITY	Cell cycle-dependent caspase-like activity that cleaves p27 -LRB- KIP1 -RRB- is the beta -LRB- 1 -RRB- subunit of the 20S proteasome .
20728136	0	KIP1	38,42	p27	34,37	KIP1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The physiological significance of p27 -LRB- KIP1 -RRB- expression in detrusor function .
21553651	0	KIP1	83,87	p27	79,82	KIP1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	PDE4 inhibitor suppresses PGE2-induced osteoclast formation via COX-2-mediated p27 -LRB- KIP1 -RRB- expression in RAW264 .7 cells .
22372491	0	KIP1	46,50	p27	42,45	KIP1	p27	1027	10671	Gene	Gene	stabilization|appos|START_ENTITY stabilization|amod|END_ENTITY	Prodigiosin down-regulates SKP2 to induce p27 -LRB- KIP1 -RRB- stabilization and antiproliferation in human lung_adenocarcinoma cells .
22584582	0	KIP1	34,38	p27	30,33	KIP1	p27	1027	10671	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Successive phosphorylation of p27 -LRB- KIP1 -RRB- protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2 .
26687548	0	KIP1	55,59	p27	50,53	KIP1	p27	1027	10671	Gene	Gene	translation|appos|START_ENTITY translation|amod|END_ENTITY	NSun2 delays replicative senescence by repressing p27 -LRB- KIP1 -RRB- translation and elevating CDK1 translation .
12586749	0	KIP1	108,112	p45	28,31	KIP1	p45	1027	6502	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of F-Box protein p45 -LRB- SKP2 -RRB- expression and stabilization of cyclin-dependent kinase inhibitor p27 -LRB- KIP1 -RRB- in vitamin_D analog-treated cancer cells .
16988944	0	KIP2	59,63	SKP2	68,72	KIP2	SKP2	1028	6502	Gene	Gene	p27|appos|START_ENTITY Downregulation|nmod|p27 Downregulation|nmod|END_ENTITY	Downregulation of the KIP family members p27 -LRB- KIP1 -RRB- and p57 -LRB- KIP2 -RRB- by SKP2 and the role of methylation in p57 -LRB- KIP2 -RRB- inactivation in nonsmall_cell_lung_cancer .
21360479	0	KIP2	40,44	decorin	24,31	KIP2	decorin	1028	1634	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of decorin and p57 -LRB- KIP2 -RRB- correlates with poor survival and lymphatic metastasis in lung_cancer patients .
10446277	0	KIP2	39,43	p57	35,38	KIP2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Spatial and temporal expression of p57 -LRB- KIP2 -RRB- during murine lens development .
10944603	0	KIP2	28,32	p57	24,27	KIP2	p57	1028	1028	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Decreased expression of p57 -LRB- KIP2 -RRB- mRNA in human bladder_cancer .
11891335	0	KIP2	17,21	p57	13,16	KIP2	p57	1028	1028	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of p57 -LRB- KIP2 -RRB- expression by p73beta .
12239171	0	KIP2	32,36	p57	28,31	KIP2	p57	1028	1028	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aberrant DNA methylation of p57 -LRB- KIP2 -RRB- gene in the promoter region in lymphoid malignancies of B-cell phenotype .
15279631	0	KIP2	4,8	p57	0,3	KIP2	p57	1028	1028	Gene	Gene	staining|compound|START_ENTITY staining|amod|END_ENTITY	p57 -LRB- KIP2 -RRB- immunohistochemical staining of gestational_trophoblastic_tumours does not identify the type of the causative pregnancy .
20626178	0	KIP2	57,61	p57	53,56	KIP2	p57	1028	1028	Gene	Gene	expression|appos|START_ENTITY expression|dep|END_ENTITY	Simultaneous detection of imprinted gene expression -LRB- p57 -LRB- KIP2 -RRB- -RRB- and molecular cytogenetics -LRB- FICTION -RRB- in the evaluation of molar_pregnancies .
9858559	0	KIP2	46,50	p57	42,45	KIP2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Cyclin D - and E-dependent kinases and the p57 -LRB- KIP2 -RRB- inhibitor : cooperative interactions in vivo .
17874532	0	KIP_1	14,19	p27	9,12	KIP 1	p27	1027	10534	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	-LSB- Role of p27 -LRB- KIP_1 -RRB- in regulation of retinal cell proliferation -RSB- .
15778373	0	KIR	140,143	KIR2DL4	149,156	KIR	KIR2DL4	553128	3805	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer_cell_Ig-like_receptors -LRB- KIR -RRB- , of KIR2DL4 , and of KIR3DL3 .
16829306	0	KIR	11,14	KIR2DS1	40,47	KIR	KIR2DS1	3805	3806	Gene	Gene	gene|compound|START_ENTITY role|nmod|gene variants|nsubj|role variants|xcomp|other other|nmod|END_ENTITY	A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis .
24529855	0	KIR	43,46	KIR2DS1	12,19	KIR	KIR2DS1	3805	3806	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of KIR2DS1 in multiple_sclerosis -- KIR in Portuguese MS patients .
25205074	0	KIR	55,58	Killer_Cell_Immunoglobulin-like_Receptor	13,53	KIR	Killer Cell Immunoglobulin-like Receptor	3806	3806	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Diversity of Killer_Cell_Immunoglobulin-like_Receptor -LRB- KIR -RRB- genes in the Bengali population of Northern West Bengal , India .
22139069	0	KIR	75,78	Killer_Ig-Like_Receptors	49,73	KIR	Killer Ig-Like Receptors	3805	3805	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	Differential impact of inhibitory and activating Killer_Ig-Like_Receptors -LRB- KIR -RRB- on high-risk patients with myeloid and lymphoid_malignancies undergoing reduced intensity transplantation from haploidentical related donors .
20082621	0	KIR	42,45	Killer_cell_immunoglobulin-like_receptor	0,40	KIR	Killer cell immunoglobulin-like receptor	3806	3806	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genes in systemic_sclerosis .
24131019	0	KIR	62,65	Killer_cell_immunoglobulin-like_receptor	20,60	KIR	Killer cell immunoglobulin-like receptor	3806	3806	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genotypes and haplotypes in Chinese Han population .
26312867	0	KIR	84,87	NKG2C	78,83	KIR	NKG2C	3805	3822	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Natural killer cell maturation markers in the human liver and expansion of an NKG2C + KIR + population .
16671942	0	KIR	58,61	killer-cell_immunoglobulin-like_receptor	16,56	KIR	killer-cell immunoglobulin-like receptor	3806	3806	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of killer-cell_immunoglobulin-like_receptor -LRB- KIR -RRB- in Comoros and Southeast France .
16818466	0	KIR	97,100	killer_cell_Ig-like_receptor	67,95	KIR	killer cell Ig-like receptor	553128	553128	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional redundancy of transcription factor-binding sites in the killer_cell_Ig-like_receptor -LRB- KIR -RRB- gene promoter .
17579070	0	KIR	43,46	killer_cell_Ig-like_receptor	13,41	KIR	killer cell Ig-like receptor	553128	553128	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Evolution of killer_cell_Ig-like_receptor -LRB- KIR -RRB- genes : definition of an orangutan KIR haplotype reveals expansion of lineage III KIR associated with the emergence of MHC-C .
12493005	0	KIR	46,49	killer_cell_immunoglobulin-like_receptor	4,44	KIR	killer cell immunoglobulin-like receptor	3806	3806	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	The killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genomic region : gene-order , haplotypes and allelic polymorphism .
18668235	0	KIR	101,104	killer_cell_immunoglobulin-like_receptor	59,99	KIR	killer cell immunoglobulin-like receptor	3806	3806	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Asian population frequencies and haplotype distribution of killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genes among Chinese , Malay , and Indian in Singapore .
19309280	0	KIR	58,61	killer_cell_immunoglobulin-like_receptor	16,56	KIR	killer cell immunoglobulin-like receptor	3806	3806	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genotypes in patients with familial_Mediterranean_fever .
20033655	0	KIR	118,121	killer_cell_immunoglobulin-like_receptor	76,116	KIR	killer cell immunoglobulin-like receptor	3806	3806	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Identification and analysis of novel transcripts and promoters in the human killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genes .
18687225	0	KIR	72,75	killer_cell_immunoglobulin_like_receptor	30,70	KIR	killer cell immunoglobulin like receptor	3806	3806	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Study on the polymorphism of killer_cell_immunoglobulin_like_receptor -LRB- KIR -RRB- gene with systemic_lupus_erythematosus of North population in China -RSB- .
10803839	0	KIR	91,94	killer_immunoglobulin-like_receptor	54,89	KIR	killer immunoglobulin-like receptor	3805	3805	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The genomic organization and evolution of the natural killer_immunoglobulin-like_receptor -LRB- KIR -RRB- gene cluster .
21114902	0	KIR	68,71	killer_immunoglobulin-like_receptor	31,66	KIR	killer immunoglobulin-like receptor	3805	3805	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of donor-derived killer_immunoglobulin-like_receptor -LRB- KIR -RRB- by sequential genotyping in hematopoietic stem cell-transplanted patients .
17060849	0	KIR	69,72	killer_immunoglobulin-like_receptors	31,67	KIR	killer immunoglobulin-like receptors	3805	3805	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Low number of donor activating killer_immunoglobulin-like_receptors -LRB- KIR -RRB- genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem_cell_transplantation .
15833103	0	KIR2DL1	68,75	killer_immunoglobulin-like_receptor	31,66	KIR2DL1	killer immunoglobulin-like receptor	3802	3805	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of inhibitory-motif killer_immunoglobulin-like_receptor , KIR2DL1 , is increased in natural killer cells from women with pelvic_endometriosis .
11821086	0	KIR2DL1	37,44	killer_inhibitory_receptor	10,36	KIR2DL1	killer inhibitory receptor	3802	3805	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Increased killer_inhibitory_receptor KIR2DL1 expression among natural killer cells in women with pelvic_endometriosis .
19700612	0	KIR2DL4	34,41	HLA-G	66,71	KIR2DL4	HLA-G	3805	3135	Gene	Gene	interaction|nmod|START_ENTITY ligand|nsubj|interaction ligand|dobj|END_ENTITY	Possible gene-gene interaction of KIR2DL4 with its cognate ligand HLA-G in modulating risk for preeclampsia .
22934097	0	KIR2DL4	0,7	HLA-G	45,50	KIR2DL4	HLA-G	3805	3135	Gene	Gene	START_ENTITY|dep|receptor receptor|nmod|END_ENTITY	KIR2DL4 -LRB- CD158d -RRB- : An activation receptor for HLA-G .
25855135	0	KIR2DL4	65,72	HLA-G	40,45	KIR2DL4	HLA-G	3805	3135	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Genetic polymorphisms and expression of HLA-G and its receptors , KIR2DL4 and LILRB1 , in non-small_cell_lung_cancer .
15778373	0	KIR2DL4	149,156	KIR	140,143	KIR2DL4	KIR	3805	553128	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer_cell_Ig-like_receptors -LRB- KIR -RRB- , of KIR2DL4 , and of KIR3DL3 .
23234877	0	KIR2DL5A	132,140	TOMM40	105,111	KIR2DL5A	TOMM40	57292	10452	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|nmod|END_ENTITY	Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A , PLOD1 , and SLC2A8 among fast progressors in early Alzheimer 's _ disease .
16829306	0	KIR2DS1	40,47	KIR	11,14	KIR2DS1	KIR	3806	3805	Gene	Gene	other|nmod|START_ENTITY variants|xcomp|other variants|nsubj|role role|nmod|gene gene|compound|END_ENTITY	A role for KIR gene variants other than KIR2DS1 in conferring susceptibility to psoriasis .
24529855	0	KIR2DS1	12,19	KIR	43,46	KIR2DS1	KIR	3806	3805	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of KIR2DS1 in multiple_sclerosis -- KIR in Portuguese MS patients .
19176033	0	KIR3DL1	25,32	E2F1	73,77	KIR3DL1	E2F1	3811	1869	Gene	Gene	expression|compound|START_ENTITY expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Molecular regulation of KIR3DL1 gene expression by transcription factor E2F1 -RSB- .
26321090	0	KIR3DL1	0,7	HLA-B27	25,32	KIR3DL1	HLA-B27	3811	3106	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	KIR3DL1 interaction with HLA-B27 is altered by ankylosing_spondylitis associated ERAP1 and enhanced by MHC class I cross-linking .
15580659	0	KIR3DP1	11,18	CD158c	25,31	KIR3DP1	CD158c	548594	548594	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The silent KIR3DP1 gene -LRB- CD158c -RRB- is transcribed and might encode a secreted receptor in a minority of humans , in whom the KIR3DP1 , KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated .
17411378	0	KIR3DS1	8,15	Bw4	39,42	KIR3DS1	Bw4	3813	474272	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8 + T cell epitopes .
17516061	0	KIRL1	57,62	NK1	83,86	KIRL1	NK1	245616(Tax:10090)	17059(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of murine killer immunoglobulin-like receptor KIRL1 on CD1d-independent NK1 .1 -LRB- + -RRB- T cells .
18424411	0	KISS-1	1,7	GPR54	8,13	KISS-1	GPR54	3814	84634	Gene	Gene	genes|dep|START_ENTITY genes|nummod|END_ENTITY	-LSB- KISS-1 / GPR54 genes and their role in reproduction -RSB- .
23716269	0	KISS1	14,19	GPR54	32,37	KISS1	GPR54	3814	84634	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of KISS1 and KISS1R -LRB- GPR54 -RRB- may be used as favorable prognostic markers for patients with non-small_cell_lung_cancer .
15654978	0	KIT	70,73	Bcl-2	0,5	KIT	Bcl-2	16590(Tax:10090)	12043(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Bcl-2 reduced and fas activated by the inhibition of stem_cell_factor / KIT signaling in murine melanocyte precursors .
11914628	0	KIT	14,17	CD117	19,24	KIT	CD117	3815	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of KIT -LRB- CD117 -RRB- in angiomyolipoma .
14677065	0	KIT	5,8	CD117	10,15	KIT	CD117	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Rare KIT -LRB- CD117 -RRB- expression in multiple_myeloma abrogates the usefulness of imatinib mesylate treatment .
14692559	0	KIT	14,17	CD117	19,24	KIT	CD117	3815	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of KIT -LRB- CD117 -RRB- in biphasic_pulmonary_blastoma .
15198361	0	KIT	18,21	CD117	23,28	KIT	CD117	3815	3815	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of KIT -LRB- CD117 -RRB- in chromophobe_renal_cell_carcinoma and renal_oncocytoma .
15336730	0	KIT	12,15	CD117	17,22	KIT	CD117	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Analysis of KIT -LRB- CD117 -RRB- expression in gallbladder_carcinomas by tissue microarray .
16015044	0	KIT	14,17	CD117	19,24	KIT	CD117	3815	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of KIT -LRB- CD117 -RRB- in renal_cell_carcinoma and renal_oncocytoma .
17381803	0	KIT	37,40	CD117	42,47	KIT	CD117	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Merkel_cell_carcinoma : evaluation of KIT -LRB- CD117 -RRB- expression and failure to demonstrate activating mutations in the C-KIT proto-oncogene - implications for treatment with imatinib_mesylate .
19683721	0	KIT	38,41	CD117	51,56	KIT	CD117	3815	3815	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein expression|appos|END_ENTITY	Immunohistochemical expression of the KIT protein -LRB- CD117 -RRB- in normal and neoplastic canine testes .
25634571	0	KIT	0,3	CD117	5,10	KIT	CD117	3815	3815	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	KIT -LRB- CD117 -RRB- Expression in Benign and Malignant Sweat Gland Tumors .
14513377	0	KIT	71,74	CD_117	76,82	KIT	CD 117	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Sequence analysis and high-throughput immunohistochemical profiling of KIT -LRB- CD_117 -RRB- expression in uveal_melanoma using tissue_microarrays .
16406868	0	KIT	19,22	KIT	38,41	KIT	KIT	3815	3815	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|mutations mutations|compound|END_ENTITY	Rare expression of KIT and absence of KIT mutations in high grade renal_cell_carcinoma .
16406868	0	KIT	38,41	KIT	19,22	KIT	KIT	3815	3815	Gene	Gene	mutations|compound|START_ENTITY expression|nmod|mutations expression|nmod|END_ENTITY	Rare expression of KIT and absence of KIT mutations in high grade renal_cell_carcinoma .
24412084	0	KIT	28,31	MicroRNA-137	0,12	KIT	MicroRNA-137	3815	406928	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	MicroRNA-137 down-regulates KIT and inhibits small_cell_lung_cancer cell proliferation .
19035305	0	KIT	155,158	PDGFRA	22,28	KIT	PDGFRA	3815	5156	Gene	Gene	mutation|compound|START_ENTITY leukaemias|nmod|mutation leukaemias|nsubj|analysis analysis|nmod|genes genes|compound|END_ENTITY	Molecular analysis of PDGFRA and PDGFRB genes by rapid single-strand conformation polymorphism -LRB- SSCP -RRB- in patients with core-binding factor leukaemias with KIT or FLT3 mutation .
22355509	0	KIT	74,77	PDGFRA	124,130	KIT	PDGFRA	3815	5156	Gene	Gene	examination|nmod|START_ENTITY examination|appos|END_ENTITY	Malignant_melanoma of the nasal cavity : a case report with examination of KIT and platelet_derived_growth_factor_receptor-a -LRB- PDGFRA -RRB- .
25165019	0	KIT	87,90	PDGFRA	92,98	KIT	PDGFRA	3815	5156	Gene	Gene	SDH|compound|START_ENTITY SDH|appos|END_ENTITY	Quadruple wild-type -LRB- WT -RRB- GIST : defining the subset of GIST that lacks abnormalities of KIT , PDGFRA , SDH , or RAS signaling pathways .
26848617	0	KIT	13,16	PDGFRA	61,67	KIT	PDGFRA	3815	5156	Gene	Gene	mutational|nsubj|START_ENTITY mutational|dobj|mutations mutations|dep|END_ENTITY	Intratumoral KIT mutational heterogeneity and recurrent KIT / PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal_stromal_tumors .
26848617	0	KIT	56,59	PDGFRA	61,67	KIT	PDGFRA	3815	5156	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Intratumoral KIT mutational heterogeneity and recurrent KIT / PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal_stromal_tumors .
18521081	0	KIT	33,36	Protein_kinase_C-theta	0,22	KIT	Protein kinase C-theta	3815	5588	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Protein_kinase_C-theta regulates KIT expression and proliferation in gastrointestinal_stromal_tumors .
15990278	0	KIT	159,162	SHIP1	91,96	KIT	SHIP1	16590(Tax:10090)	16331(Tax:10090)	Gene	Gene	mutants|nmod|START_ENTITY END_ENTITY|nmod|mutants	Differences in signaling pathways and expression level of the phosphoinositide phosphatase SHIP1 between two oncogenic mutants of the receptor_tyrosine_kinase KIT .
25962936	0	KIT	26,29	Stem_Cell_Factor	79,95	KIT	Stem Cell Factor	3815	4254	Gene	Gene	Maintenance|nmod|START_ENTITY Human|nsubj|Maintenance Human|dobj|Secretion Secretion|nmod|END_ENTITY	Maintenance of Clonogenic KIT -LRB- + -RRB- Human Colon_Tumor Cells Requires Secretion of Stem_Cell_Factor by Differentiated Tumor Cells .
25962936	0	KIT	26,29	Stem_Cell_Factor	79,95	KIT	Stem Cell Factor	3815	4254	Gene	Gene	Maintenance|nmod|START_ENTITY Human|nsubj|Maintenance Human|dobj|Secretion Secretion|nmod|END_ENTITY	Maintenance of Clonogenic KIT -LRB- + -RRB- Human Colon_Tumor Cells Requires Secretion of Stem_Cell_Factor by Differentiated Tumor Cells .
12444320	0	KIT	66,69	bcl-2	104,109	KIT	bcl-2	3815	596	Gene	Gene	Activation|appos|START_ENTITY associated|nsubjpass|Activation associated|nmod|expression expression|nmod|END_ENTITY	Activation of human mast cells through stem_cell_factor receptor -LRB- KIT -RRB- is associated with expression of bcl-2 .
25766129	0	KIT	6,9	c-KIT	47,52	KIT	c-KIT	3815	3815	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	BRAF , KIT and NRAS mutations and expression of c-KIT , phosphorylated extracellular signal-regulated kinase and phosphorylated AKT in Japanese melanoma patients .
17298867	0	KIT	22,25	c-kit	47,52	KIT	c-kit	3815	3815	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing_sarcomas .
11522667	0	KIT	43,46	receptor_tyrosine_kinase	18,42	KIT	receptor tyrosine kinase	16590(Tax:10090)	22174(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the receptor_tyrosine_kinase KIT in mature beta-cells and in the pancreas in development .
11874486	0	KIT	137,140	stem_cell_factor	120,136	KIT	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	proliferation|dep|START_ENTITY proliferation|nmod|END_ENTITY	Transforming_growth_factor_beta1 regulates melanocyte proliferation and differentiation in mouse neural crest cells via stem_cell_factor / KIT signaling .
12444320	0	KIT	66,69	stem_cell_factor	39,55	KIT	stem cell factor	3815	4254	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|cells cells|nmod|receptor receptor|compound|END_ENTITY	Activation of human mast cells through stem_cell_factor receptor -LRB- KIT -RRB- is associated with expression of bcl-2 .
17662946	0	KIT	64,67	stem_cell_factor	71,87	KIT	stem cell factor	3815	4254	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Structural basis for activation of the receptor tyrosine kinase KIT by stem_cell_factor .
18830255	0	KIT	33,36	stem_cell_factor	16,32	KIT	stem cell factor	3815	4254	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	The key role of stem_cell_factor / KIT signaling in the proliferation of blast cells from Down syndrome-related_leukemia .
20857409	0	KIT	0,3	stem_cell_factor	51,67	KIT	stem cell factor	3815	4254	Gene	Gene	receptor|compound|START_ENTITY activation|nsubj|receptor activation|nmod|growth growth|compound|END_ENTITY	KIT receptor activation by autocrine and paracrine stem_cell_factor stimulates growth of merkel_cell_carcinoma in vitro .
25213795	0	KITLG	0,5	miR-34c	27,34	KITLG	miR-34c	4254	407042	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	KITLG is a novel target of miR-34c that is associated with the inhibition of growth and invasion in colorectal_cancer cells .
15378028	0	KIT_ligand	6,16	HMGA1	53,58	KIT ligand	HMGA1	4254	3159	Gene	Gene	promoter|compound|START_ENTITY regulated|nsubjpass|promoter regulated|nmod|END_ENTITY	Human KIT_ligand promoter is positively regulated by HMGA1 in breast_and_ovarian_cancer cells .
18602222	0	KIT_ligand	40,50	SCF	32,35	KIT ligand	SCF	4254	4254	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- , a KIT_ligand , in gastrointestinal_stromal_tumors -LRB- GISTs -RRB- : a potential marker for tumor proliferation .
11090434	0	KIT_ligand	83,93	growth_differentiation_factor-9	26,57	KIT ligand	growth differentiation factor-9	17311(Tax:10090)	14566(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Comparison of recombinant growth_differentiation_factor-9 and oocyte regulation of KIT_ligand messenger ribonucleic acid expression in mouse ovarian follicles .
24120139	0	KIT_ligand	38,48	p53	14,17	KIT ligand	p53	4254	7157	Gene	Gene	element|nmod|START_ENTITY element|compound|END_ENTITY	A polymorphic p53 response element in KIT_ligand influences cancer risk and has undergone natural selection .
16647379	0	KIT_ligand	44,54	stem_cell_factor	27,43	KIT ligand	stem cell factor	4254	4254	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Investigation of the human stem_cell_factor KIT_ligand gene , KITLG , in women with 46 , XX spontaneous premature_ovarian_failure .
18602222	0	KIT_ligand	40,50	stem_cell_factor	14,30	KIT ligand	stem cell factor	4254	4254	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- , a KIT_ligand , in gastrointestinal_stromal_tumors -LRB- GISTs -RRB- : a potential marker for tumor proliferation .
26329623	0	KL-6	56,60	Krebs_von_den_Lungen-6	33,55	KL-6	Krebs von den Lungen-6	4582	4582	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	-LSB- Immunohistochemical Analysis of Krebs_von_den_Lungen-6 -LRB- KL-6 -RRB- Expression in Lung Tissue in Primary Lung_Cancer Patients with High Serum KL-6 Levels -RSB- .
12924525	0	KL-6	0,4	MUC1	14,18	KL-6	MUC1	4582	4582	Gene	Gene	START_ENTITY|appos|mucin mucin|compound|END_ENTITY	KL-6 , a human MUC1 mucin , is expressed early in premature lung .
16289035	0	KL-6	0,4	MUC1	14,18	KL-6	MUC1	4582	4582	Gene	Gene	START_ENTITY|appos|mucin mucin|compound|END_ENTITY	KL-6 , a human MUC1 mucin , promotes proliferation and survival of lung fibroblasts .
21466814	0	KL-6	14,18	MUC1	19,23	KL-6	MUC1	4582	4582	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of KL-6 / MUC1 in pancreatic_ductal_carcinoma and its potential relationship with b-catenin in tumor progression .
21617869	0	KL-6	14,18	MUC1	19,23	KL-6	MUC1	4582	4582	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of KL-6 / MUC1 in pancreatic_cancer tissues and its potential involvement in tumor metastasis .
9330247	0	KL-6	111,115	MUC1	125,129	KL-6	MUC1	4582	4582	Gene	Gene	START_ENTITY|appos|mucin mucin|compound|END_ENTITY	Detection of interstitial_pneumonitis in patients with rheumatoid_arthritis by measuring circulating levels of KL-6 , a human MUC1 mucin .
9376125	0	KL-6	0,4	MUC1	14,18	KL-6	MUC1	4582	4582	Gene	Gene	START_ENTITY|appos|mucin mucin|compound|END_ENTITY	KL-6 , a human MUC1 mucin , is chemotactic for human fibroblasts .
17511270	0	KL-6	54,58	SP-D	48,52	KL-6	SP-D	4582	6441	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Immunity tests for respiratory_diseases -- SP-A , SP-D , KL-6 -RSB- .
17135299	0	KLF-4	61,66	hSMVT	43,48	KLF-4	hSMVT	9314	8884	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2 : confirmation of promoter activity in vivo .
20676097	0	KLF1	0,4	BCL11A	15,21	KLF1	BCL11A	10661	53335	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	KLF1 regulates BCL11A expression and gamma - to beta-globin gene switching .
24866116	0	KLF1	41,45	EKLF	35,39	KLF1	EKLF	10661	10661	Gene	Gene	control|appos|START_ENTITY control|nmod|END_ENTITY	Extrinsic and intrinsic control by EKLF -LRB- KLF1 -RRB- within a specialized erythroid niche .
22566683	0	KLF1	23,27	KLF2	30,34	KLF1	KLF2	16596(Tax:10090)	16598(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Kruppel-like factor 1 -LRB- KLF1 -RRB- , KLF2 , and Myc control a regulatory network essential for embryonic erythropoiesis .
24060634	0	KLF11	0,5	glycodelin-A	31,43	KLF11	glycodelin-A	8462	5047	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	KLF11 epigenetically regulates glycodelin-A , a marker of endometrial biology via histone-modifying chromatin mechanisms .
15716005	0	KLF13	38,43	FKLF-2	30,36	KLF13	FKLF-2	51621	51621	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of FKLF-2 -LRB- KLF13 -RRB- gene in erythroid cells .
12097321	0	KLF15	25,30	GLUT4	83,88	KLF15	GLUT4	66277(Tax:10090)	20528(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The Kr ppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4 .
24680826	0	KLF15	0,5	NFATc1	59,65	KLF15	NFATc1	66277(Tax:10090)	18018(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	KLF15 regulates slow myosin heavy chain expression through NFATc1 in C2C12 myotubes .
18586263	0	KLF15	24,29	connective_tissue_growth_factor	39,70	KLF15	connective tissue growth factor	85497(Tax:10116)	64032(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	The Kruppel-like factor KLF15 inhibits connective_tissue_growth_factor -LRB- CTGF -RRB- expression in cardiac fibroblasts .
18555530	0	KLF2	68,72	Dpp2	29,33	KLF2	Dpp2	16598(Tax:10090)	83768(Tax:10090)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1 .
20042720	0	KLF2	107,111	HDAC5	74,79	KLF2	HDAC5	10365	10014	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS .
22566683	0	KLF2	30,34	KLF1	23,27	KLF2	KLF1	16598(Tax:10090)	16596(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Kruppel-like factor 1 -LRB- KLF1 -RRB- , KLF2 , and Myc control a regulatory network essential for embryonic erythropoiesis .
25672609	0	KLF2	78,82	SUZ12	0,5	KLF2	SUZ12	10365	23512	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	SUZ12 promotes gastric_cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin .
17194892	0	KLF2	0,4	TGF-beta	16,24	KLF2	TGF-beta	10365	7040	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1 .
22737924	0	KLF2	36,40	gamma-GCS	58,67	KLF2	gamma-GCS	306330(Tax:10116)	25283(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The effect of transcription factor KLF2 in expression of gamma-GCS depend on regulation by Nrf2 in lung of rats with chronic_obstructive_pulmonary_disease -RSB- .
12426306	0	KLF2	25,29	peroxisome_proliferator-activated_receptor-gamma	39,87	KLF2	peroxisome proliferator-activated receptor-gamma	10365	5468	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	The Kr ppel-like factor KLF2 inhibits peroxisome_proliferator-activated_receptor-gamma expression and adipogenesis .
22306741	0	KLF4	36,40	DLK2	0,4	KLF4	DLK2	16600(Tax:10090)	106565(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis .
23272250	0	KLF4	70,74	EP300	4,9	KLF4	EP300	16600(Tax:10090)	328572(Tax:10090)	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	The EP300 , KDM5A , KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1 .
18379898	0	KLF4	54,58	HSC70	45,50	KLF4	HSC70	16600(Tax:10090)	15481(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|dobj|END_ENTITY	Upregulation of the constitutively expressed HSC70 by KLF4 .
23846700	0	KLF4	0,4	IL-6	29,33	KLF4	IL-6	9314	3569	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification .
26224477	0	KLF4	16,20	MiR-375	0,7	KLF4	MiR-375	9314	494324	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MiR-375 targets KLF4 and impacts the proliferation of colorectal_carcinoma .
25181544	0	KLF4	80,84	MiR-7	0,5	KLF4	MiR-7	9314	10859	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-7 promotes epithelial cell transformation by targeting the tumor suppressor KLF4 .
20075075	0	KLF4	53,57	MicroRNA-10b	0,12	KLF4	MicroRNA-10b	9314	406903	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal_cancer cell lines .
24573354	0	KLF4	53,57	MicroRNA-10b	0,12	KLF4	MicroRNA-10b	9314	406903	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder_cancer .
20689077	0	KLF4	11,15	OCT3/4	111,117	KLF4	OCT3/4	9314	5460	Gene	Gene	expression|compound|START_ENTITY allows|nsubj|expression allows|advcl|reprogramming reprogramming|xcomp|pluripotency pluripotency|nmod|END_ENTITY	Endogenous KLF4 expression in human fetal endothelial cells allows for reprogramming to pluripotency with just OCT3/4 and SOX2 -- brief report .
24792165	0	KLF4	77,81	OCT4	54,58	KLF4	OCT4	9314	5460	Gene	Gene	SOX2|appos|START_ENTITY END_ENTITY|appos|SOX2	Engineered zinc-finger transcription factors activate OCT4 -LRB- POU5F1 -RRB- , SOX2 , KLF4 , c-MYC -LRB- MYC -RRB- and miR302/367 .
16563348	0	KLF4	74,78	PSG-5	56,61	KLF4	PSG-5	9314	5673	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|promoter promoter|compound|END_ENTITY	Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1 .
20454664	0	KLF4	41,45	Platelet_factor_4	0,17	KLF4	Platelet factor 4	16600(Tax:10090)	56744(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Platelet_factor_4 regulation of monocyte KLF4 in experimental cerebral_malaria .
25882815	0	KLF4	12,16	TGFb	20,24	KLF4	TGFb	9314	7040	Gene	Gene	role|nmod|START_ENTITY role|nmod|responses responses|compound|END_ENTITY	The role of KLF4 in TGFb induced inflammatory and fibrotic responses in human proximal tubule cells .
22364861	0	KLF4	41,45	ZNF750	0,6	KLF4	ZNF750	9314	79755	Gene	Gene	induces|dobj|START_ENTITY gene|acl:relcl|induces gene|nsubj|END_ENTITY	ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation .
25228645	0	KLF4	22,26	ZNF750	0,6	KLF4	ZNF750	9314	79755	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ZNF750 interacts with KLF4 and RCOR1 , KDM1A , and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes .
21132436	0	KLF4	12,16	cyclin_D1	87,96	KLF4	cyclin D1	16600(Tax:10090)	12443(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of KLF4 in UVB-induced murine skin_tumor development and its correlation with cyclin_D1 , p53 , and p21 -LRB- Waf1/Cip1 -RRB- in epithelial_tumors of the human skin .
23384942	0	KLF4	81,85	miR-7	0,5	KLF4	miR-7	9314	10859	Gene	Gene	modulating|dobj|START_ENTITY suppresses|advcl|modulating suppresses|nsubj|END_ENTITY	miR-7 suppresses brain metastasis of breast_cancer stem-like cells by modulating KLF4 .
26269755	0	KLF4	21,25	microRNA-544	36,48	KLF4	microRNA-544	9314	664613	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Transcription factor KLF4 regulates microRNA-544 that targets YWHAZ in cervical_cancer .
25896712	0	KLF5	0,4	AKT	76,79	KLF5	AKT	688	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|compound|END_ENTITY	KLF5 inhibits angiogenesis in PTEN-deficient_prostate_cancer by attenuating AKT activation and subsequent HIF1a accumulation .
18178156	0	KLF5	27,31	Complement_3	0,12	KLF5	Complement 3	84410(Tax:10116)	24232(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY activates|dobj|gene activates|nsubj|END_ENTITY	Complement_3 activates the KLF5 gene in rat vascular smooth muscle cells .
19569049	0	KLF5	37,41	ER	65,67	KLF5	ER	688	2099	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Estrogen-induced interaction between KLF5 and estrogen_receptor -LRB- ER -RRB- suppresses the function of ER in ER-positive breast_cancer cells .
26786295	0	KLF5	0,4	FYN	46,49	KLF5	FYN	12224(Tax:10090)	14360(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	KLF5 promotes cell migration by up-regulating FYN in bladder_cancer cells .
26574507	0	KLF5	16,20	Ppara	31,36	KLF5	Ppara	12224(Tax:10090)	19013(Tax:10090)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|compound|END_ENTITY	Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function .
16595680	0	KLF5	0,4	p53	20,23	KLF5	p53	688	7157	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	KLF5 Interacts with p53 in regulating survivin expression in acute_lymphoblastic_leukemia .
21868761	0	KLF5	29,33	p53	52,55	KLF5	p53	688	7157	Gene	Gene	START_ENTITY|nmod|context context|nmod|ablation ablation|compound|END_ENTITY	Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous_cell_cancer .
22990386	0	KLF5	66,70	p53	0,3	KLF5	p53	688	7157	Gene	Gene	effect|nmod|START_ENTITY alters|dobj|effect alters|nsubj|mutation mutation|compound|END_ENTITY	p53 mutation alters the effect of the esophageal_tumor suppressor KLF5 on keratinocyte proliferation .
24398995	0	KLF6	83,87	COL6A3	68,74	KLF6	COL6A3	420463(Tax:9031)	396548(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	KLF6	83,87	EDNRB	76,81	KLF6	EDNRB	420463(Tax:9031)	408082(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
23085750	0	KLF6	29,33	GSK3b	0,5	KLF6	GSK3b	1316	2932	Gene	Gene	suppressor|compound|START_ENTITY phosphorylation|nmod|suppressor phosphorylation|amod|END_ENTITY	GSK3b phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21 .
24398995	0	KLF6	83,87	IGF2R	55,60	KLF6	IGF2R	420463(Tax:9031)	395817(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
15486921	0	KLF6	69,73	Kruppel-like_factor_6	46,67	KLF6	Kruppel-like factor 6	1316	1316	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Frequent inactivation of the tumor suppressor Kruppel-like_factor_6 -LRB- KLF6 -RRB- in hepatocellular_carcinoma .
26850053	0	KLF6	21,25	MMP14	68,73	KLF6	MMP14	1316	4323	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular_injury .
26874000	0	KLF6	0,4	NUR77	21,26	KLF6	NUR77	1316	3164	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 Leydig cells .
23353867	0	KLF6	49,53	PPAR_alpha	35,45	KLF6	PPAR alpha	1316	5465	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Post-transcriptional activation of PPAR_alpha by KLF6 in hepatic_steatosis .
24398995	0	KLF6	83,87	RGS2	62,66	KLF6	RGS2	420463(Tax:9031)	378912(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
20801538	0	KLF6	19,23	SV2	4,7	KLF6	SV2	1316	9900	Gene	Gene	variant|nmod|START_ENTITY variant|compound|END_ENTITY	The SV2 variant of KLF6 is down-regulated in hepatocellular_carcinoma and displays anti-proliferative and pro-apoptotic functions .
19076057	0	KLF6	58,62	TGF-beta	0,8	KLF6	TGF-beta	1316	7040	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction .
24398995	0	KLF6	83,87	folr1	48,53	KLF6	folr1	420463(Tax:9031)	395638(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
20123021	0	KLF6/7	39,45	Tuba1a	0,6	KLF6/7	Tuba1a	280650;553670	573216(Tax:7955)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish .
26320172	0	KLF8	0,4	FHL2	113,117	KLF8	FHL2	11279	2274	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	KLF8 promotes tumorigenesis , invasion and metastasis of colorectal_cancer cells by transcriptional activation of FHL2 .
21151179	0	KLF8	0,4	MMP9	96,100	KLF8	MMP9	11279	4318	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	KLF8 promotes human breast_cancer cell invasion and metastasis by transcriptional activation of MMP9 .
11836360	0	KLF8	27,31	ZNF741	33,39	KLF8	ZNF741	11279	11279	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Abnormal expression of the KLF8 -LRB- ZNF741 -RRB- gene in a female patient with an X ; autosome translocation t -LRB- X ; 21 -RRB- -LRB- p11 .2 ; q22 .3 -RRB- and non-syndromic_mental_retardation .
18353772	0	KLF8	14,18	focal_adhesion_kinase	36,57	KLF8	focal adhesion kinase	11279	5747	Gene	Gene	Activation|nmod|START_ENTITY transcription|nsubj|Activation transcription|nmod|END_ENTITY	Activation of KLF8 transcription by focal_adhesion_kinase in human ovarian epithelial and cancer cells .
23102700	0	KLHDC10	25,32	ASK1	68,72	KLHDC10	ASK1	23008	4217	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5 .
18303015	0	KLHL12	12,18	dopamine_D4_receptor	31,51	KLHL12	dopamine D4 receptor	59349	1815	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	BTB Protein KLHL12 targets the dopamine_D4_receptor for ubiquitination by a Cul3-based E3 ligase .
20686372	0	KLK10	33,38	Kallikrein-related_peptidase_10	0,31	KLK10	Kallikrein-related peptidase 10	5655	5655	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Kallikrein-related_peptidase_10 -LRB- KLK10 -RRB- expression and single nucleotide polymorphisms in ovarian_cancer survival .
21487810	0	KLK10	80,85	kallikrein-related_peptidase_10	47,78	KLK10	kallikrein-related peptidase 10	5655	5655	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis and clinical evaluation of kallikrein-related_peptidase_10 -LRB- KLK10 -RRB- in colorectal_cancer .
11920956	0	KLK10	78,83	kallikrein_10	63,76	KLK10	kallikrein 10	5655	5655	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the human kallikrein_10 -LRB- KLK10 -RRB- gene and their association with prostate , breast , testicular , and ovarian_cancers .
14568187	0	KLK10	55,60	kallikrein_10	40,53	KLK10	kallikrein 10	5655	5655	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Steroid hormone regulation of the human kallikrein_10 -LRB- KLK10 -RRB- gene in cancer cell lines and functional characterization of the KLK10 gene promoter .
16800741	0	KLK11	49,54	kallikrein_11	34,47	KLK11	kallikrein 11	11012	11012	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	mRNA expression analysis of human kallikrein_11 -LRB- KLK11 -RRB- may be useful in the discrimination of benign_prostatic_hyperplasia from prostate_cancer after needle prostate biopsy .
22429520	0	KLK11	63,68	kallikrein_11	48,61	KLK11	kallikrein 11	11012	11012	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Diagnostic and prognostic significance of human kallikrein_11 -LRB- KLK11 -RRB- mRNA expression levels in patients with laryngeal_cancer .
15300858	0	KLK12	61,66	kallikrein_12	46,59	KLK12	kallikrein 12	43849	43849	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Splice-site genetic polymorphism of the human kallikrein_12 -LRB- KLK12 -RRB- gene correlates with no substantial expression of KLK12 protein having serine_protease activity .
11986781	0	KLK13	26,31	kallikrein_gene_13	6,24	KLK13	kallikrein gene 13	26085	26085	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Human kallikrein_gene_13 -LRB- KLK13 -RRB- expression by quantitative RT-PCR : an independent indicator of favourable prognosis in breast_cancer .
21057706	0	KLK14	100,105	kallikrein-related_peptidase_14	62,93	KLK14	kallikrein-related peptidase 14	43847	43847	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Quantitative expression analysis and study of the novel human kallikrein-related_peptidase_14 gene -LRB- KLK14 -RRB- in malignant and benign breast tissues .
20155713	0	KLK14	21,26	kallikrein_14	6,19	KLK14	kallikrein 14	43847	43847	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human kallikrein_14 -LRB- KLK14 -RRB- expression in salivary_gland_tumors .
12858357	0	KLK14	57,62	kallikrein_gene_14	37,55	KLK14	kallikrein gene 14	43847	43847	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of the human kallikrein_gene_14 -LRB- KLK14 -RRB- in normal and cancerous prostatic tissues .
11010966	0	KLK15	51,56	kallikrein	31,41	KLK15	kallikrein	55554	9622	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of the human kallikrein 15 gene -LRB- KLK15 -RRB- .
17085659	0	KLK2	34,38	hK2	16,19	KLK2	hK2	3817	58164	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of the hK2 protein gene -LRB- KLK2 -RRB- are associated with serum hK2 levels and predict the presence of prostate_cancer at biopsy .
17085659	0	KLK2	34,38	hK2	66,69	KLK2	hK2	3817	58164	Gene	Gene	gene|appos|START_ENTITY Variants|nmod|gene associated|nsubjpass|Variants associated|nmod|levels levels|amod|END_ENTITY	Variants of the hK2 protein gene -LRB- KLK2 -RRB- are associated with serum hK2 levels and predict the presence of prostate_cancer at biopsy .
24270797	0	KLK2	21,25	hK2	72,75	KLK2	hK2	3817	58164	Gene	Gene	variation|nmod|START_ENTITY associated|nsubjpass|variation associated|nmod|concentrations concentrations|nmod|END_ENTITY	Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men .
19407151	0	KLK4	18,22	DPPI	0,4	KLK4	DPPI	56640(Tax:10090)	13032(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	DPPI may activate KLK4 during enamel formation .
23201139	0	KLK4	32,36	Kallikrein-related_peptidase_4	0,30	KLK4	Kallikrein-related peptidase 4	9622	9622	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Kallikrein-related_peptidase_4 -LRB- KLK4 -RRB- mRNA predicts short-term relapse in colorectal_adenocarcinoma patients .
15766562	0	KLK5	0,4	kallikrein	47,57	KLK5	kallikrein	25818	9622	Gene	Gene	START_ENTITY|appos|members members|nmod|family family|compound|END_ENTITY	KLK5 and KLK7 , two members of the human tissue kallikrein family , are differentially expressed in lung_cancer .
21906360	0	KLK5	51,55	kallikrein-related_peptidase_5	19,49	KLK5	kallikrein-related peptidase 5	25818	25818	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Down-regulation of kallikrein-related_peptidase_5 -LRB- KLK5 -RRB- expression in breast_cancer patients : a biomarker for the differential diagnosis of breast_lesions .
19299547	0	KLK5	45,49	kallikrein_5	31,43	KLK5	kallikrein 5	25818	25818	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Quantitative analysis of human kallikrein_5 -LRB- KLK5 -RRB- expression in prostate needle biopsies : an independent cancer biomarker .
11948967	0	KLK5	48,52	kallikrein_gene_5	29,46	KLK5	kallikrein gene 5	25818	25818	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of the human kallikrein_gene_5 -LRB- KLK5 -RRB- in prostate_cancer tissues .
12142380	0	KLK5	25,29	kallikrein_gene_5	6,23	KLK5	kallikrein gene 5	25818	25818	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Human kallikrein_gene_5 -LRB- KLK5 -RRB- expression by quantitative PCR : an independent indicator of poor prognosis in breast_cancer .
24430362	0	KLK6	32,36	Kallikrein-related_peptidase-6	0,30	KLK6	Kallikrein-related peptidase-6	5653	5653	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Kallikrein-related_peptidase-6 -LRB- KLK6 -RRB- mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal_adenocarcinoma .
22373580	0	KLK6	62,66	kallikrein-related_peptidase_6	30,60	KLK6	kallikrein-related peptidase 6	5653	5653	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation and secretion of kallikrein-related_peptidase_6 -LRB- KLK6 -RRB- in gastric_cancer .
23376368	0	KLK6	52,56	kallikrein-related_peptidase_6	20,50	KLK6	kallikrein-related peptidase 6	19144(Tax:10090)	19144(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	In vivo analysis of kallikrein-related_peptidase_6 -LRB- KLK6 -RRB- function in oligodendrocyte development and the expression of myelin proteins .
12480753	0	KLK6	50,54	neurosin	40,48	KLK6	neurosin	5653	5653	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Decreased cerebrospinal fluid levels of neurosin -LRB- KLK6 -RRB- , an aging-related protease , as a possible new risk factor for Alzheimer 's _ disease .
10974542	0	KLK7	4,8	PRSS6	10,15	KLK7	PRSS6	5650	5650	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The KLK7 -LRB- PRSS6 -RRB- gene , encoding for the stratum_corneum_chymotryptic_enzyme is a new member of the human kallikrein gene family - genomic characterization , mapping , tissue expression and hormonal regulation .
12147714	0	KLK8	52,56	serine_protease	24,39	KLK8	serine protease	11202	2147	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Epidermal expression of serine_protease , neuropsin -LRB- KLK8 -RRB- in normal and pathological skin samples .
20940292	0	KLK8	32,36	serine_protease	51,66	KLK8	serine protease	11202	2147	Gene	Gene	Kallikrein-related_peptidase-8|appos|START_ENTITY END_ENTITY|nsubj|Kallikrein-related_peptidase-8	Kallikrein-related_peptidase-8 -LRB- KLK8 -RRB- is an active serine_protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade .
12725415	0	KLK9	53,57	kallikrein_gene_9	34,51	KLK9	kallikrein gene 9	284366	284366	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The prognostic value of the human kallikrein_gene_9 -LRB- KLK9 -RRB- in breast_cancer .
10188912	0	KLK_3	44,49	prostate_specific_antigen	51,76	KLK 3	prostate specific antigen	354	354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The promoter and the enhancer region of the KLK_3 -LRB- prostate_specific_antigen -RRB- gene is frequently mutated in breast_tumours and in breast_carcinoma cell lines .
19085836	0	KLK_5	21,26	kallikrein	9,19	KLK 5	kallikrein	25818	9622	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Multiple kallikrein -LRB- KLK_5 , 7 , 8 , and 10 -RRB- expression in squamous_cell_carcinoma_of_the_oral_cavity .
14521834	0	KLP64D	59,65	KAP	11,14	KLP64D	KAP	38611(Tax:7227)	32071(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Drosophila KAP interacts with the kinesin_II motor subunit KLP64D to assemble chordotonal sensory cilia , but not sperm tails .
24337749	0	KLRG1	0,5	CD4	14,17	KLRG1	CD4	10219	920	Gene	Gene	responses|nummod|START_ENTITY responses|compound|END_ENTITY	KLRG1 impairs CD4 + T cell responses via p16ink4a and p27kip1 pathways : role in hepatitis_B_vaccine_failure in individuals with hepatitis_C_virus infection .
16140789	0	KLRG1	45,50	CD8	69,72	KLRG1	CD8	10219	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation .
19406987	0	KLRG1	0,5	CD8	118,121	KLRG1	CD8	10219	925	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling induces|dobj|phosphorylation phosphorylation|nmod|cells cells|compound|END_ENTITY	KLRG1 signaling induces defective Akt -LRB- ser473 -RRB- phosphorylation and proliferative dysfunction of highly differentiated CD8 + T cells .
23089397	0	KLRG1	26,31	CD8	53,56	KLRG1	CD8	10219	925	Gene	Gene	Contribution|nmod|START_ENTITY END_ENTITY|nsubj|Contribution	Contribution of pulmonary KLRG1 -LRB- high -RRB- and KLRG1 -LRB- low -RRB- CD8 T cells to effector and memory responses during influenza_virus_infection .
24022692	0	KLRG1	74,79	CD8	9,12	KLRG1	CD8	10219	925	Gene	Gene	phenotype|compound|START_ENTITY driven|nmod|phenotype driven|nsubjpass|cells cells|compound|END_ENTITY	Expanded CD8 + T cells of murine and human CLL are driven into a senescent KLRG1 + effector memory phenotype .
19604491	0	KLRG1	42,47	E-cadherin	57,67	KLRG1	E-cadherin	10219	999	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Structure of natural killer cell receptor KLRG1 bound to E-cadherin reveals basis for MHC-independent missing self recognition .
21346231	0	KLRG1	0,5	NKG2A	6,11	KLRG1	NKG2A	50928(Tax:10090)	16641(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	KLRG1 + NKG2A + CD8 T cells mediate protection and participate in memory responses during y-herpesvirus infection .
17307799	0	KLRG1	0,5	SHIP-1	57,63	KLRG1	SHIP-1	50928(Tax:10090)	16331(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	KLRG1 binds cadherins and preferentially associates with SHIP-1 .
11220622	0	KLRG1	111,116	killer_cell_lectin-like_receptor_G1	69,104	KLRG1	killer cell lectin-like receptor G1	50928(Tax:10090)	50928(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure , alternative splicing , and physical mapping of the killer_cell_lectin-like_receptor_G1 gene -LRB- KLRG1 -RRB- , the mouse homologue of MAFA .
24886118	0	KMT2A	24,29	MLL	31,34	KMT2A	MLL	4297	4297	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	De Novo variants in the KMT2A -LRB- MLL -RRB- gene causing atypical Wiedemann-Steiner_syndrome in two unrelated individuals identified by clinical exome sequencing .
26164398	0	KMT2A	0,5	MLLT1	12,17	KMT2A	MLLT1	4297	4298	Gene	Gene	START_ENTITY|dep|rearrangement rearrangement|compound|END_ENTITY	KMT2A -LRB- MLL -RRB- - MLLT1 rearrangement in blastic plasmacytoid dendritic_cell_neoplasm .
18390591	0	KNAT6	15,20	BREVIPEDICELLUS	36,51	KNAT6	BREVIPEDICELLUS	838946(Tax:3702)	826364(Tax:3702)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of KNAT6 and KNAT2 with BREVIPEDICELLUS and PENNYWISE in Arabidopsis inflorescences .
21457372	0	KNAT7	46,51	OFP4	23,27	KNAT7	OFP4	842602(Tax:3702)	837202(Tax:3702)	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	OVATE FAMILY PROTEIN4 -LRB- OFP4 -RRB- interaction with KNAT7 regulates secondary cell wall formation in Arabidopsis_thaliana .
1733668	0	KNG	45,48	kininogen	29,38	KNG	kininogen	3827	3827	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal mapping of human kininogen gene -LRB- KNG -RRB- to 3q26 -- qter .
12839500	0	KNS2	67,71	kinesin_light_chain_1	44,65	KNS2	kinesin light chain 1	3831	3831	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternatively spliced products of the human kinesin_light_chain_1 -LRB- KNS2 -RRB- gene .
25147605	0	KOR	57,60	k_Opioid_Receptor	38,55	KOR	k Opioid Receptor	4986	4986	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and Pharmacology of a Novel k_Opioid_Receptor -LRB- KOR -RRB- Agonist with a 1,3,5-Trioxazatriquinane Skeleton .
21406623	0	KP1	20,23	VDAC3	52,57	KP1	VDAC3	823602(Tax:3702)	831361(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arabidopsis kinesin KP1 specifically interacts with VDAC3 , a mitochondrial protein , and regulates respiration during seed germination at low temperature .
26974341	0	KPC-1	53,58	DMA-1	44,49	KPC-1	DMA-1	173051(Tax:6239)	187968(Tax:6239)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Precise regulation of the guidance receptor DMA-1 by KPC-1 / Furin instructs dendritic_branching_decisions .
22978676	0	KPC-2	38,43	bla	34,37	KPC-2	bla	13914015	1238792(Tax:573)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization of the bla -LRB- KPC-2 -RRB- gene in clinical isolates of carbapenem-resistant Klebsiella_pneumoniae from the pediatric wards of a Chinese hospital .
23268335	0	KPNA2	60,65	karyopherin_a_2	43,58	KPNA2	karyopherin a 2	3838	3838	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The functional role of the novel biomarker karyopherin_a_2 -LRB- KPNA2 -RRB- in cancer .
22253232	0	KR-POK	0,6	p53	22,25	KR-POK	p53	207259(Tax:10090)	22060(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A .
22787409	0	KRAS	68,72	ALK	58,61	KRAS	ALK	3845	238	Gene	Gene	MET|dep|START_ENTITY MET|appos|END_ENTITY	Biomarkers that currently affect clinical practice : EGFR , ALK , MET , KRAS .
26373952	0	KRAS	35,39	ALK	47,50	KRAS	ALK	3845	238	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
19638574	0	KRAS	80,84	B-RAF	71,76	KRAS	B-RAF	3845	673	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Sorafenib inhibits non-small_cell_lung_cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells .
26245900	0	KRAS	11,15	BCL-XL	34,40	KRAS	BCL-XL	3845	598	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism .
22383492	0	KRAS	10,14	BMP4	25,29	KRAS	BMP4	3845	652	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Oncogenic KRAS regulates BMP4 expression in colon_cancer cell lines .
16144912	0	KRAS	73,77	BRAF	0,4	KRAS	BRAF	3845	673	Gene	Gene	correlation|nmod|START_ENTITY mutation|dep|correlation mutation|compound|END_ENTITY	BRAF mutation in endometrial_carcinoma and hyperplasia : correlation with KRAS and p53 mutations and mismatch repair protein expression .
16256179	0	KRAS	80,84	BRAF	22,26	KRAS	BRAF	3845	673	Gene	Gene	status|compound|START_ENTITY mutations|nmod|status mutations|nsubj|absence absence|nmod|END_ENTITY	Consistent absence of BRAF mutations in cervical and endometrial_cancer despite KRAS mutation status .
19087308	0	KRAS	32,36	BRAF	56,60	KRAS	BRAF	3845	673	Gene	Gene	G12D|compound|START_ENTITY expression|nmod|G12D expression|nmod|context context|compound|END_ENTITY	Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context .
20012784	0	KRAS	23,27	BRAF	11,15	KRAS	BRAF	3845	673	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
20627194	0	KRAS	126,130	BRAF	180,184	KRAS	BRAF	24525(Tax:10116)	114486(Tax:10116)	Gene	Gene	V-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog|dep|START_ENTITY V-raf_murine_sarcoma_viral_oncogene_homolog_B1|amod|V-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog V-raf_murine_sarcoma_viral_oncogene_homolog_B1|appos|END_ENTITY	Cycleave polymerase chain reaction method is practically applicable for V-Ki-ras2_Kirsten_rat_sarcoma_viral_oncogene_homolog -LRB- KRAS -RRB- / V-raf_murine_sarcoma_viral_oncogene_homolog_B1 -LRB- BRAF -RRB- genotyping in colorectal_cancer .
21163703	0	KRAS	0,4	BRAF	6,10	KRAS	BRAF	3845	673	Gene	Gene	PIK3CA|compound|START_ENTITY PIK3CA|appos|END_ENTITY	KRAS , BRAF , PIK3CA , and PTEN mutations : implications for targeted therapies in metastatic colorectal_cancer .
21340604	0	KRAS	12,16	BRAF	18,22	KRAS	BRAF	3845	673	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
22938585	0	KRAS	87,91	BRAF	94,98	KRAS	BRAF	3845	673	Gene	Gene	PIK3CA|compound|START_ENTITY PIK3CA|appos|END_ENTITY	High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS , BRAF , PIK3CA , and AKT1 mutations in formalin-fixed , paraffin-embedded tissues .
23585181	0	KRAS	27,31	BRAF	15,19	KRAS	BRAF	3845	673	Gene	Gene	START_ENTITY|nsubj|Application Application|nmod|NRAS NRAS|compound|END_ENTITY	Application of BRAF , NRAS , KRAS mutations as markers for the detection of papillary thyroid_cancer from FNAB specimens by pyrosequencing analysis .
24549645	0	KRAS	0,4	BRAF	14,18	KRAS	BRAF	3845	673	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	KRAS -LRB- but not BRAF -RRB- mutations in ovarian_serous_borderline_tumour are associated with recurrent low-grade serous_carcinoma .
24594201	0	KRAS	26,30	BRAF	32,36	KRAS	BRAF	3845	673	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
24861115	0	KRAS	33,37	BRAF	1,5	KRAS	BRAF	3845	673	Gene	Gene	patients|compound|START_ENTITY mutation|nmod|patients mutation|compound|END_ENTITY	-LSB- BRAF gene mutation in wild-type KRAS patients with colorectal_cancers -RSB- .
25153497	0	KRAS	55,59	BRAF	69,73	KRAS	BRAF	3845	673	Gene	Gene	Genes|appos|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
26004768	4	KRAS	1076,1080	BRAF	1082,1086	KRAS	NRAS	3845	4893	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26325103	0	KRAS	0,4	BRAF	12,16	KRAS	BRAF	3845	673	Gene	Gene	START_ENTITY|appos|comparison comparison|amod|END_ENTITY	KRAS , NRAS , BRAF mutation comparison of endoscopic and surgically removed primary CRC paired samples : is endoscopy biopsy material adequate for molecular evaluation ?
26341080	0	KRAS	108,112	BRAF	20,24	KRAS	BRAF	3845	673	Gene	Gene	Chemotherapy|compound|START_ENTITY Patients|nmod|Chemotherapy Value|nmod|Patients Value|nmod|Number Number|compound|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26352110	0	KRAS	0,4	BRAF	12,16	KRAS	BRAF	3845	673	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	KRAS , NRAS , BRAF mutations and high counts of poorly_differentiated_clusters of neoplastic cells in colorectal_cancer : observational analysis of 175 cases .
26373952	0	KRAS	35,39	BRAF	41,45	KRAS	BRAF	3845	673	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26842788	0	KRAS	75,79	BRAF	81,85	KRAS	BRAF	3845	673	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
26991109	0	KRAS	58,62	BRAF	0,4	KRAS	BRAF	3845	673	Gene	Gene	Status|compound|START_ENTITY Alterations|nmod|Status Alterations|nsubj|PIK3CA PIK3CA|compound|END_ENTITY	BRAF , PIK3CA , and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal_Cancers with Distant Metastasis .
26991344	0	KRAS	10,14	BRAF	16,20	KRAS	BRAF	3845	673	Gene	Gene	PIK3CA|compound|START_ENTITY PIK3CA|appos|END_ENTITY	Impact of KRAS , BRAF , PIK3CA , TP53 status and intra-individual mutation heterogeneity on outcome after liver resection for colorectal_cancer metastases .
19638574	0	KRAS	114,118	C-RAF	105,110	KRAS	C-RAF	3845	5894	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Sorafenib inhibits non-small_cell_lung_cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells .
26121339	0	KRAS	44,48	CTNNB1	35,41	KRAS	CTNNB1	3845	1499	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Correction : Selective Targeting of CTNNB1 - , KRAS - or MYC-Driven Cell Growth by Combinations of Existing Drugs .
23558076	0	KRAS	67,71	DAB2IP	24,30	KRAS	DAB2IP	3845	153090	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of DAB2IP in pancreatic_cancer with wild-type KRAS .
17534846	0	KRAS	35,39	EGFR	116,120	KRAS	EGFR	16653(Tax:10090)	13649(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY representation|nmod|mutation representation|nmod|adenomatous_hyperplasia adenomatous_hyperplasia|nmod|distribution distribution|nmod|mutation mutation|amod|END_ENTITY	Disproportionate representation of KRAS gene mutation in atypical adenomatous_hyperplasia , but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas .
17591931	0	KRAS	82,86	EGFR	52,56	KRAS	EGFR	3845	1956	Gene	Gene	mutation|compound|START_ENTITY correlates|nmod|mutation correlates|nmod|mutation mutation|amod|END_ENTITY	Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung_adenocarcinomas with bronchioloalveolar_features .
18619559	0	KRAS	0,4	EGFR	35,39	KRAS	EGFR	3845	1956	Gene	Gene	mutations|compound|START_ENTITY predict|nsubj|mutations predict|nmod|inhibitors inhibitors|amod|END_ENTITY	KRAS mutations predict response to EGFR inhibitors .
19378369	0	KRAS	0,4	EGFR	75,79	KRAS	EGFR	3845	1956	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|use use|nmod|inhibitors inhibitors|amod|END_ENTITY	KRAS mutation in metastatic colorectal_cancer and its impact on the use of EGFR inhibitors .
19596959	0	KRAS	36,40	EGFR	13,17	KRAS	EGFR	3845	1956	Gene	Gene	START_ENTITY|nsubj|Dominance Dominance|nmod|END_ENTITY	Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status .
19943202	0	KRAS	12,16	EGFR	44,48	KRAS	EGFR	3845	1956	Gene	Gene	role|nmod|START_ENTITY mutations|nsubj|role mutations|nmod|inhibition inhibition|amod|END_ENTITY	The role of KRAS mutations in resistance to EGFR inhibition in the treatment of cancer .
20034873	0	KRAS	1,5	EGFR	20,24	KRAS	EGFR	3845	1956	Gene	Gene	START_ENTITY|dobj|status status|nmod|status status|amod|END_ENTITY	-LSB- KRAS status versus EGFR status in lung_cancer therapy -RSB- .
20049837	0	KRAS	75,79	EGFR	20,24	KRAS	EGFR	3845	1956	Gene	Gene	status|compound|START_ENTITY signaling|nmod|status downstream|xcomp|signaling downstream|nsubj|value value|nmod|END_ENTITY	Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal_cancer .
20108024	0	KRAS	40,44	EGFR	111,115	KRAS	EGFR	3845	1956	Gene	Gene	mutations|compound|START_ENTITY significance|nmod|mutations significance|dep|driver driver|acl:relcl|contrasts contrasts|nmod|mutation mutation|amod|END_ENTITY	Biological and clinical significance of KRAS mutations in lung_cancer : an oncogenic driver that contrasts with EGFR mutation .
20381121	0	KRAS	94,98	EGFR	0,4	KRAS	EGFR	3845	1956	Gene	Gene	mutations|compound|START_ENTITY coexisting|dobj|mutations incidence|acl|coexisting fluorescence|dep|incidence fluorescence|amod|END_ENTITY	EGFR fluorescence in situ hybridization-positive lung_adenocarcinoma : incidence of coexisting KRAS and BRAF mutations .
20616015	0	KRAS	69,73	EGFR	45,49	KRAS	EGFR	3845	1956	Gene	Gene	cells|amod|START_ENTITY eliminate|dobj|cells eliminate|nsubj|antibodies antibodies|nmod|END_ENTITY	T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS - and BRAF-mutated colorectal_cancer cells .
20884623	0	KRAS	107,111	EGFR	0,4	KRAS	EGFR	3845	1956	Gene	Gene	cetuximab|nmod|START_ENTITY patients|amod|cetuximab predicts|nmod|patients predicts|nsubj|fluorescence fluorescence|amod|END_ENTITY	EGFR fluorescence in situ hybridization pattern of chromosome 7 disomy predicts resistance to cetuximab in KRAS wild-type metastatic colorectal_cancer patients .
21118963	0	KRAS	70,74	EGFR	122,126	KRAS	EGFR	3845	1956	Gene	Gene	START_ENTITY|acl|mutated mutated|dobj|colorectal_cancer colorectal_cancer|acl:relcl|resistant resistant|nmod|therapy therapy|amod|END_ENTITY	MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal_cancer that is resistant to EGFR monoclonal antibody therapy .
22082529	0	KRAS	116,120	EGFR	69,73	KRAS	EGFR	3845	1956	Gene	Gene	cells|compound|START_ENTITY inhibition|nmod|cells enhances|nmod|inhibition enhances|nsubj|Down-regulation Down-regulation|appos|regulator regulator|nmod|END_ENTITY	Down-regulation of mitogen-inducible_gene_6 , a negative regulator of EGFR , enhances resistance to MEK inhibition in KRAS mutant cancer cells .
22329297	0	KRAS	13,17	EGFR	100,104	KRAS	EGFR	3845	1956	Gene	Gene	testing|compound|START_ENTITY role|nmod|testing -LSB-|dobj|role -LSB-|nmod|END_ENTITY	-LSB- The role of KRAS gene mutation testing in colorectal_cancer -- a predictive biomarker of response to EGFR inhibitors therapy -RSB- .
22491422	0	KRAS	148,152	EGFR	21,25	KRAS	EGFR	3845	1956	Gene	Gene	cells|compound|START_ENTITY cetuximab|nmod|cells contribute|xcomp|cetuximab contribute|nsubj|Cross-suppression Cross-suppression|nmod|amphiregulin amphiregulin|amod|END_ENTITY	Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells .
22496619	0	KRAS	10,14	EGFR	23,27	KRAS	EGFR	16653(Tax:10090)	13649(Tax:10090)	Gene	Gene	impairs|nsubj|START_ENTITY impairs|dobj|efficiency efficiency|nmod:poss|antibodies antibodies|compound|END_ENTITY	Oncogenic KRAS impairs EGFR antibodies ' efficiency by C/EBPb-dependent suppression of EGFR expression .
22496619	0	KRAS	10,14	EGFR	86,90	KRAS	EGFR	16653(Tax:10090)	13649(Tax:10090)	Gene	Gene	impairs|nsubj|START_ENTITY impairs|nmod|suppression suppression|nmod|expression expression|amod|END_ENTITY	Oncogenic KRAS impairs EGFR antibodies ' efficiency by C/EBPb-dependent suppression of EGFR expression .
22706026	0	KRAS	66,70	EGFR	89,93	KRAS	EGFR	3845	1956	Gene	Gene	START_ENTITY|dobj|tumors tumors|nmod|repression repression|amod|END_ENTITY	Triepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression .
22770374	0	KRAS	26,30	EGFR	124,128	KRAS	EGFR	3845	1956	Gene	Gene	Impact|nmod|START_ENTITY advanced|nsubj|Impact advanced|nmod|genotype genotype|amod|END_ENTITY	Impact of specific mutant KRAS on clinical outcome of EGFR-TKI-treated advanced non-small_cell_lung_cancer patients with an EGFR wild_type genotype .
22787409	0	KRAS	68,72	EGFR	52,56	KRAS	EGFR	3845	1956	Gene	Gene	MET|dep|START_ENTITY MET|compound|END_ENTITY	Biomarkers that currently affect clinical practice : EGFR , ALK , MET , KRAS .
23874486	0	KRAS	49,53	EGFR	80,84	KRAS	EGFR	3845	1956	Gene	Gene	mutation|compound|START_ENTITY abundance|nmod|mutation patients|nmod|abundance benefit|nsubj|patients benefit|nmod|therapy therapy|amod|END_ENTITY	Colorectal_cancer patients with low abundance of KRAS mutation may benefit from EGFR antibody therapy .
23930206	0	KRAS	6,10	EGFR	0,4	KRAS	EGFR	3845	1956	Gene	Gene	BRAF|appos|START_ENTITY BRAF|compound|END_ENTITY	EGFR , KRAS , BRAF , and HER-2 molecular status in brain metastases from 77 NSCLC patients .
24025416	0	KRAS	56,60	EGFR	10,14	KRAS	EGFR	3845	1956	Gene	Gene	colorectal_carcinoma|compound|START_ENTITY detected|nmod|colorectal_carcinoma detected|nsubjpass|mutation mutation|compound|END_ENTITY	The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal_carcinoma before exposure to EGFR monoclonal antibodies .
24025416	0	KRAS	56,60	EGFR	111,115	KRAS	EGFR	3845	1956	Gene	Gene	colorectal_carcinoma|compound|START_ENTITY detected|nmod|colorectal_carcinoma detected|nmod|antibodies antibodies|amod|END_ENTITY	The S492R EGFR ectodomain mutation is never detected in KRAS wild-type colorectal_carcinoma before exposure to EGFR monoclonal antibodies .
24122611	0	KRAS	6,10	EGFR	0,4	KRAS	EGFR	3845	1956	Gene	Gene	BRAF|appos|START_ENTITY BRAF|compound|END_ENTITY	EGFR , KRAS , BRAF , and PIK3CA characterization in squamous_cell_anal_cancer .
24139827	0	KRAS	154,158	EGFR	88,92	KRAS	EGFR	3845	1956	Gene	Gene	status|compound|START_ENTITY segregated|nmod|status segregated|nsubj|outcome outcome|nmod|chemotherapy chemotherapy|nmod|patients patients|nmod|non-small-cell_lung_cancer non-small-cell_lung_cancer|compound|END_ENTITY	Clinical outcome with platinum-based chemotherapy in patients with advanced nonsquamous EGFR wild-type non-small-cell_lung_cancer segregated according to KRAS mutation status .
24594201	0	KRAS	26,30	EGFR	20,24	KRAS	EGFR	3845	1956	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
24595598	0	KRAS	93,97	EGFR	0,4	KRAS	EGFR	3845	1956	Gene	Gene	colorectal_cancer|compound|START_ENTITY patients|nmod|colorectal_cancer factors|nmod|patients factors|nsubj|gain gain|amod|END_ENTITY	EGFR gene gain and PTEN protein expression are favorable prognostic factors in patients with KRAS wild-type metastatic colorectal_cancer treated with cetuximab .
25153497	0	KRAS	55,59	EGFR	49,53	KRAS	EGFR	3845	1956	Gene	Gene	Genes|appos|START_ENTITY Genes|compound|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
25808440	0	KRAS	73,77	EGFR	10,14	KRAS	EGFR	3845	1956	Gene	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	Targeting EGFR in metastatic colorectal_cancer beyond the limitations of KRAS status : alternative biomarkers and therapeutic strategies .
25992771	0	KRAS	74,78	EGFR	118,122	KRAS	EGFR	3845	1956	Gene	Gene	lung_cancer|compound|START_ENTITY subsets|nmod|lung_cancer efficacy|nmod|subsets resistant|nsubj|efficacy resistant|nmod|blockade blockade|compound|END_ENTITY	Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung_cancer resistant to single EGFR blockade .
26341080	0	KRAS	108,112	EGFR	38,42	KRAS	EGFR	3845	1956	Gene	Gene	Chemotherapy|compound|START_ENTITY Patients|nmod|Chemotherapy Value|nmod|Patients Value|nmod|Number Number|appos|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26373952	0	KRAS	35,39	EGFR	29,33	KRAS	EGFR	3845	1956	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|compound|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26448020	0	KRAS	59,63	EGFR	21,25	KRAS	EGFR	3845	1956	Gene	Gene	Colorectal_Cancer|compound|START_ENTITY Analysis|nmod|Colorectal_Cancer Analysis|nmod|Status Status|compound|END_ENTITY	Combined Analysis of EGFR and PTEN Status in Patients With KRAS Wild-Type Metastatic Colorectal_Cancer .
26668065	0	KRAS	155,159	EGFR	26,30	KRAS	EGFR	3845	1956	Gene	Gene	Status|compound|START_ENTITY Independent|nmod|Status Cells|nmod|Independent Activity|nmod|Cells Shows|dobj|Activity Shows|nsubj|Afatinib Afatinib|appos|Inhibitor Inhibitor|compound|END_ENTITY	Afatinib , an Irreversible EGFR Family Inhibitor , Shows Activity Toward Pancreatic_Cancer Cells , Alone and in Combination with Radiotherapy , Independent of KRAS Status .
26799287	0	KRAS	16,20	EGFR	101,105	KRAS	EGFR	3845	1956	Gene	Gene	Contribution|nmod|START_ENTITY mutations|nsubj|Contribution mutations|nmod|NSCLC NSCLC|compound|END_ENTITY	Contribution of KRAS mutations and c. 2369C _ > _ T -LRB- p.T790M -RRB- EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC : a study on circulating tumor DNA .
26799287	0	KRAS	16,20	EGFR	57,61	KRAS	EGFR	3845	1956	Gene	Gene	Contribution|nmod|START_ENTITY mutations|nsubj|Contribution mutations|dobj|END_ENTITY	Contribution of KRAS mutations and c. 2369C _ > _ T -LRB- p.T790M -RRB- EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC : a study on circulating tumor DNA .
26842788	0	KRAS	75,79	EGFR	69,73	KRAS	EGFR	3845	1956	Gene	Gene	PIK3CA|appos|START_ENTITY PIK3CA|compound|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
24685132	0	KRAS	42,46	ERBB3	113,118	KRAS	ERBB3	3845	2065	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon_cancer through transcriptional induction of ERBB3 .
26732596	0	KRAS	48,52	ERK	22,25	KRAS	ERK	24525(Tax:10116)	24338(Tax:10116)	Gene	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	MiR-126 Regulates the ERK Pathway via Targeting KRAS to Inhibit the Glioma Cell Proliferation and Invasion .
17611392	6	KRAS	1184,1188	G12V	1189,1193	KRAS	IGF1	3845	3479	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	A series of such KRAS radiohybridization probes with 0 , 1 , 2 or 3 mismatches to KRAS G12D mRNA , including exact matches to wild type KRAS mRNA and KRAS G12V mRNA , along with a double d -LRB- Ala -RRB- replacement IGF1 peptide control , were assembled by continuous solid phase synthesis .
20012784	0	KRAS	23,27	HRAS	29,33	KRAS	HRAS	3845	3265	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
22820081	0	KRAS	33,37	HRAS	27,31	KRAS	HRAS	3845	3265	Gene	Gene	NRAS|dep|START_ENTITY NRAS|compound|END_ENTITY	The mutational spectrum of HRAS , KRAS , NRAS and FGFR3 genes in bladder_cancer .
23666916	0	KRAS	90,94	HRAS	102,106	KRAS	HRAS	3845	3265	Gene	Gene	START_ENTITY|dep|BRAF BRAF|compound|END_ENTITY	FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type -LRB- KRAS , NRAS , HRAS , BRAF -RRB- metastatic colorectal_cancer patients : a phase II trial by the Gruppo Oncologico Nord Ovest -LRB- GONO -RRB- .
21340604	0	KRAS	12,16	IGF1R	30,35	KRAS	IGF1R	3845	3480	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
24054548	0	KRAS	17,21	LKB1	0,4	KRAS	LKB1	3845	6794	Gene	Gene	adenocarcinoma_of_the_lung|compound|START_ENTITY mutant|nmod|adenocarcinoma_of_the_lung mutant|compound|END_ENTITY	LKB1 mutant in a KRAS activated adenocarcinoma_of_the_lung associated with Peutz-Jeghers_syndrome : a case report .
25500543	0	KRAS	10,14	LRP6	69,73	KRAS	LRP6	3845	4040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Oncogenic KRAS signalling promotes the Wnt/b-catenin pathway through LRP6 in colorectal_cancer .
19018267	0	KRAS	0,4	MEK	69,72	KRAS	MEK	3845	5609	Gene	Gene	predictor|nsubj|START_ENTITY predictor|nmod|sensitivity sensitivity|nmod|inhibition_in_ovarian_cancer inhibition_in_ovarian_cancer|compound|END_ENTITY	KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition_in_ovarian_cancer .
19401449	0	KRAS	65,69	MEK	47,50	KRAS	MEK	3845	5609	Gene	Gene	cancers|compound|START_ENTITY inhibitors|nmod|cancers inhibitors|compound|END_ENTITY	PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers .
20358631	0	KRAS	0,4	MEK	63,66	KRAS	MEK	3845	5609	Gene	Gene	START_ENTITY|acl:relcl|responsive responsive|nmod|activation activation|compound|END_ENTITY	KRAS mutant lung_cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation : implication for combinatorial approach .
22082529	0	KRAS	116,120	MEK	98,101	KRAS	MEK	3845	5609	Gene	Gene	cells|compound|START_ENTITY inhibition|nmod|cells inhibition|compound|END_ENTITY	Down-regulation of mitogen-inducible_gene_6 , a negative regulator of EGFR , enhances resistance to MEK inhibition in KRAS mutant cancer cells .
23934108	0	KRAS	58,62	MEK	13,16	KRAS	MEK	3845	5609	Gene	Gene	efficacy|nmod|START_ENTITY determines|dobj|efficacy determines|nsubj|Mechanism Mechanism|nmod|inhibition inhibition|compound|END_ENTITY	Mechanism of MEK inhibition determines efficacy in mutant KRAS - versus BRAF-driven cancers .
24685132	0	KRAS	42,46	MEK	24,27	KRAS	MEK	3845	5609	Gene	Gene	START_ENTITY|nsubj|resistance resistance|nmod|inhibition inhibition|compound|END_ENTITY	Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon_cancer through transcriptional induction of ERBB3 .
24746704	0	KRAS	87,91	MEK	28,31	KRAS	MEK	3845	5609	Gene	Gene	tumors|compound|START_ENTITY inhibition|nmod|tumors required|nmod|inhibition required|nsubjpass|Disruption Disruption|nmod|activation activation|compound|END_ENTITY	Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors .
24746704	0	KRAS	87,91	MEK	69,72	KRAS	MEK	3845	5609	Gene	Gene	tumors|compound|START_ENTITY inhibition|nmod|tumors inhibition|compound|END_ENTITY	Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors .
24931611	0	KRAS	80,84	MEK	62,65	KRAS	MEK	3845	5609	Gene	Gene	colorectal_cancer|compound|START_ENTITY inhibitors|nmod|colorectal_cancer inhibitors|compound|END_ENTITY	ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal_cancer .
25167228	0	KRAS	0,4	MEK	107,110	KRAS	MEK	3845	5609	Gene	Gene	subtype|compound|START_ENTITY predict|nsubj|subtype predict|nmod|inhibition inhibition|compound|END_ENTITY	KRAS mutational subtype and copy number predict in vitro response of human pancreatic_cancer cell lines to MEK inhibition .
25199829	0	KRAS	50,54	MEK	32,35	KRAS	MEK	3845	5609	Gene	Gene	cells|compound|START_ENTITY inhibition|nmod|cells inhibition|compound|END_ENTITY	RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells .
25326806	0	KRAS	89,93	MEK	8,11	KRAS	MEK	16653(Tax:10090)	17242(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY inhibition|nmod|effect inhibition|compound|END_ENTITY	Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF_and_matrix_metallopeptidase-9 .
26075998	0	KRAS	86,90	MEK	12,15	KRAS	MEK	3845	5609	Gene	Gene	mutation|compound|START_ENTITY cervix|nmod|mutation small_cell_neuroendocrine_carcinoma|nmod|cervix inhibitor|nmod|small_cell_neuroendocrine_carcinoma inhibitor|nsubj|Response Response|nmod|END_ENTITY	Response to MEK inhibitor in small_cell_neuroendocrine_carcinoma of the cervix with a KRAS mutation .
26404261	0	KRAS	43,47	MEK	19,22	KRAS	MEK	3845	5609	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|Pathway Pathway|compound|END_ENTITY	Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal_Cancers .
25756961	0	KRAS	24,28	MiR-4689	40,48	KRAS	MiR-4689	3845	100616421	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal_Cancer .
11668501	0	KRAS	45,49	NF2	28,31	KRAS	NF2	3845	4771	Gene	Gene	NRAS|dep|START_ENTITY NRAS|compound|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
20012784	0	KRAS	23,27	NRAS	17,21	KRAS	NRAS	3845	4893	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
23585181	0	KRAS	27,31	NRAS	21,25	KRAS	NRAS	3845	4893	Gene	Gene	START_ENTITY|nsubj|Application Application|nmod|END_ENTITY	Application of BRAF , NRAS , KRAS mutations as markers for the detection of papillary thyroid_cancer from FNAB specimens by pyrosequencing analysis .
25132659	0	KRAS	21,25	NRAS	68,72	KRAS	NRAS	3845	4893	Gene	Gene	mutations|compound|START_ENTITY nodules|nmod|mutations different|nsubj|nodules different|nmod|nodules nodules|nmod|mutations mutations|compound|END_ENTITY	Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics .
26004768	4	KRAS	1076,1080	NRAS	1088,1092	KRAS	BRAF	3845	673	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26352110	0	KRAS	0,4	NRAS	6,10	KRAS	NRAS	3845	4893	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	KRAS , NRAS , BRAF mutations and high counts of poorly_differentiated_clusters of neoplastic cells in colorectal_cancer : observational analysis of 175 cases .
20571907	0	KRAS	20,24	PIK3CA	0,6	KRAS	PIK3CA	3845	5290	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	PIK3CA mutations in KRAS and BRAF wild type colorectal_cancer patients .
22039088	0	KRAS	103,107	PIK3CA	0,6	KRAS	PIK3CA	3845	5290	Gene	Gene	colorectal_cancer|compound|START_ENTITY antibodies|nmod|colorectal_cancer exon|nmod|antibodies END_ENTITY|acl|exon	PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal_cancer : a systematic review and meta-analysis .
22285706	0	KRAS	163,167	PIK3CA	42,48	KRAS	PIK3CA	3845	5290	Gene	Gene	colorectal_cancer|compound|START_ENTITY patients|nmod|colorectal_cancer therapy|nmod|patients PTEN|nmod|therapy PTEN|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal_growth_factor_receptor antibody therapy in patients with KRAS wild-type metastatic colorectal_cancer .
22302407	0	KRAS	111,115	PIK3CA	117,123	KRAS	PIK3CA	3845	5290	Gene	Gene	MET|compound|START_ENTITY MET|appos|END_ENTITY	Optimization of patient selection for EGFR-TKIs in advanced non-small_cell_lung_cancer by combined analysis of KRAS , PIK3CA , MET , and non-sensitizing EGFR mutations .
24576621	0	KRAS	93,97	PIK3CA	75,81	KRAS	PIK3CA	16653(Tax:10090)	18706(Tax:10090)	Gene	Gene	colorectal_cancer|compound|START_ENTITY wild-type|appos|colorectal_cancer wild-type|nummod|END_ENTITY	Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type , KRAS mutant colorectal_cancer .
24701207	0	KRAS	159,163	PIK3CA	139,145	KRAS	PIK3CA	3845	5290	Gene	Gene	patients|compound|START_ENTITY mutations|nmod|patients mutations|nummod|END_ENTITY	Anti-epidermal_growth_factor_receptor monoclonal antibody-based therapy for metastatic colorectal_cancer : a meta-analysis of the effect of PIK3CA mutations in KRAS wild-type patients .
25153497	0	KRAS	55,59	PIK3CA	61,67	KRAS	PIK3CA	3845	5290	Gene	Gene	Genes|appos|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
26004768	4	KRAS	1076,1080	PIK3CA	1094,1100	KRAS	PIK3CA	3845	5290	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26019684	0	KRAS	117,121	PIK3CA	0,6	KRAS	PIK3CA	3845	5290	Gene	Gene	Mutation|compound|START_ENTITY Adenomas|nmod|Mutation Common|nmod|Adenomas Common|nsubj|Amplification Amplification|compound|END_ENTITY	PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation .
26019684	0	KRAS	117,121	PIK3CA	0,6	KRAS	PIK3CA	3845	5290	Gene	Gene	Mutation|compound|START_ENTITY Adenomas|nmod|Mutation Common|nmod|Adenomas Common|nsubj|Amplification Amplification|compound|END_ENTITY	PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation .
26373952	0	KRAS	35,39	PIK3CA	52,58	KRAS	PIK3CA	3845	5290	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26991109	0	KRAS	58,62	PIK3CA	6,12	KRAS	PIK3CA	3845	5290	Gene	Gene	Status|compound|START_ENTITY Alterations|nmod|Status Alterations|nsubj|END_ENTITY	BRAF , PIK3CA , and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal_Cancers with Distant Metastasis .
11668501	0	KRAS	45,49	PTEN	39,43	KRAS	PTEN	3845	5728	Gene	Gene	NRAS|dep|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
19212633	0	KRAS	119,123	PTEN	0,4	KRAS	PTEN	3845	5728	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells downstream|acl|signaling mediating|dobj|downstream cetuximab|advcl|mediating response|acl|cetuximab controls|dobj|response controls|nsubj|expression expression|compound|END_ENTITY	PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-type , hormone refractory_prostate_cancer cells .
19884556	0	KRAS	99,103	PTEN	12,16	KRAS	PTEN	3845	5728	Gene	Gene	colon_cancer|compound|START_ENTITY therapy|nmod|colon_cancer determining|nmod|therapy status|advcl|determining status|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of PTEN , BRAF , and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon_cancer .
21340604	0	KRAS	12,16	PTEN	24,28	KRAS	PTEN	3845	5728	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
22285706	0	KRAS	163,167	PTEN	0,4	KRAS	PTEN	3845	5728	Gene	Gene	colorectal_cancer|compound|START_ENTITY patients|nmod|colorectal_cancer therapy|nmod|patients END_ENTITY|nmod|therapy	PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal_growth_factor_receptor antibody therapy in patients with KRAS wild-type metastatic colorectal_cancer .
23996432	0	KRAS	174,178	PTEN	12,16	KRAS	PTEN	3845	5728	Gene	Gene	chemotherapy|nmod|START_ENTITY refractory|xcomp|chemotherapy refractory|nsubj|status status|nmod|END_ENTITY	Analysis of PTEN , BRAF and PI3K status for determination of benefit from cetuximab therapy in metastatic colorectal_cancer patients refractory to chemotherapy with wild-type KRAS .
24594201	0	KRAS	26,30	PTEN	38,42	KRAS	PTEN	3845	5728	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
26341080	0	KRAS	108,112	PTEN	32,36	KRAS	PTEN	3845	5728	Gene	Gene	Chemotherapy|compound|START_ENTITY Patients|nmod|Chemotherapy Value|nmod|Patients Value|nmod|Number Number|appos|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26245900	0	KRAS	11,15	STAT3	53,58	KRAS	STAT3	3845	6774	Gene	Gene	Protein|compound|START_ENTITY Protein|nmod|END_ENTITY	The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism .
11668501	0	KRAS	45,49	TP53	33,37	KRAS	TP53	3845	7157	Gene	Gene	NRAS|dep|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
22430215	0	KRAS	10,14	dual-specificity_phosphatase_4	91,121	KRAS	dual-specificity phosphatase 4	3845	1846	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity_phosphatase_4 -LRB- DUSP4/MKP2 -RRB- resulting in nuclear ERK1/2 inhibition .
21873159	0	KRAS	10,14	miR-200c	25,33	KRAS	miR-200c	3845	406985	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|222 222|amod|END_ENTITY	Oncogenic KRAS regulates miR-200c and miR-221 / 222 in a 3D-specific manner in colorectal_cancer cells .
24368337	0	KRAS	19,23	miR-200c	39,47	KRAS	miR-200c	3845	406985	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|advcl|END_ENTITY	The proto-oncogene KRAS is targeted by miR-200c .
26392416	0	KRAS	59,63	miR-200c	0,8	KRAS	miR-200c	3845	406985	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	miR-200c inhibits breast_cancer proliferation by targeting KRAS .
20675343	0	KRAS	112,116	miR-217	4,11	KRAS	miR-217	16653(Tax:10090)	387213(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	The miR-217 microRNA functions as a potential tumor suppressor in pancreatic_ductal_adenocarcinoma by targeting KRAS .
22701724	0	KRAS	89,93	miR-30c	67,74	KRAS	miR-30c	3845	407031	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|advcl|regulating	Deregulated miRNAs in hereditary_breast_cancer revealed a role for miR-30c in regulating KRAS oncogene .
26755660	0	KRAS	114,118	miR-3923	105,113	KRAS	miR-3923	3845	100500877	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic_cancer by derepressing the miR-3923 / KRAS pathway .
20610624	0	KRAS	20,24	miRNA-96	0,8	KRAS	miRNA-96	3845	407053	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic_cancer .
8256512	0	KRE2	26,30	KTR2	0,4	KRE2	KTR2	852094(Tax:4932)	853935(Tax:4932)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	KTR2 : a new member of the KRE2 mannosyltransferase gene family .
25413039	0	KRIT-1	97,103	CCM1	105,109	KRIT-1	CCM1	889	889	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Cerebral_Cavernous_Malformations and Unilateral Moyamoya in a Patient with a New Mutation in the KRIT-1 / CCM1 Gene .
11161805	0	KRIT1	89,94	CCM1	96,100	KRIT1	CCM1	889	889	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 -LRB- CCM1 -RRB- gene .
11854171	0	KRIT1	0,5	ICAP-1	52,58	KRIT1	ICAP-1	889	9270	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	KRIT1 association with the integrin-binding protein ICAP-1 : a new direction in the elucidation of cerebral_cavernous_malformations -LRB- CCM1 -RRB- pathogenesis .
16712798	0	KRIT1	153,158	Sorting_nexin_17	0,16	KRIT1	Sorting nexin 17	889	9784	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sorting_nexin_17 , a non-self-assembling and a PtdIns -LRB- 3 -RRB- P high class affinity protein , interacts with the cerebral_cavernous_malformation related protein KRIT1 .
25059659	0	KRIT1	127,132	sorting_nexin_17	39,55	KRIT1	sorting nexin 17	889	9784	Gene	Gene	Krev_interaction_trapped_1|appos|START_ENTITY Krev_interaction_trapped_1|amod|binding binding|nmod|END_ENTITY	Structural determinants for binding of sorting_nexin_17 -LRB- SNX17 -RRB- to the cytoplasmic_adaptor protein Krev_interaction_trapped_1 -LRB- KRIT1 -RRB- .
20423613	0	KRP4	42,46	Kip-related_protein_4	14,35	KRP4	Kip-related protein 4	817831(Tax:3702)	817831(Tax:3702)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|gene gene|compound|END_ENTITY	Expression of Kip-related_protein_4 gene -LRB- KRP4 -RRB- in response to auxin and cytokinin during growth of Arabidopsis_thaliana .
8675026	0	KRR1	52,56	YCL059c	58,65	KRR1	YCL059c	850298(Tax:4932)	850298(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel cross-phylum family of proteins comprises a KRR1 -LRB- YCL059c -RRB- gene which is essential for viability of Saccharomyces_cerevisiae cells .
16352477	0	KRT12	112,117	keratin_12	100,110	KRT12	keratin 12	3859	3859	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Meesmann_corneal_dystrophy -LRB- MECD -RRB- : report of 2 families and a novel mutation in the cornea specific keratin_12 -LRB- KRT12 -RRB- gene .
1385306	0	KRT13	50,55	cytokeratin_13	29,43	KRT13	cytokeratin 13	3860	3860	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal mapping of human cytokeratin_13 gene -LRB- KRT13 -RRB- .
18713255	0	KRT14	99,104	keratin_14	82,92	KRT14	keratin 14	3861	3861	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical heterogeneity in recessive_epidermolysis_bullosa due to mutations in the keratin_14 gene , KRT14 .
9804355	0	KRT14	128,133	keratin_14	111,121	KRT14	keratin 14	3861	3861	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Severe palmo-plantar_hyperkeratosis in Dowling-Meara epidermolysis_bullosa simplex caused by a mutation in the keratin_14 gene -LRB- KRT14 -RRB- .
9804344	0	KRT2E	62,67	keratin_2e	45,55	KRT2E	keratin 2e	3849	3849	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and fine mapping of the keratin_2e gene -LRB- KRT2E -RRB- : K2e V1 domain polymorphism and novel mutations in ichthyosis_bullosa_of_Siemens .
7510223	0	KRT3	44,48	cytokeratin_3	24,37	KRT3	cytokeratin 3	3850	3850	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human cytokeratin_3 gene -LRB- KRT3 -RRB- to 12q12 -- > q13 by FISH .
1377166	0	KRT5	44,48	keratin_5	33,42	KRT5	keratin 5	3852	3852	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regional assignment of the human keratin_5 -LRB- KRT5 -RRB- gene to chromosome 12q near D12S14 by PCR analysis of somatic cell hybrids and multicolor in situ hybridization .
21188418	0	KRT74	35,40	keratin-74	23,33	KRT74	keratin-74	121391	121391	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations in the keratin-74 -LRB- KRT74 -RRB- gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families .
18573708	0	KRT9	33,37	keratin_9	22,31	KRT9	keratin 9	3857	3857	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Identification of the keratin_9 -LRB- KRT9 -RRB- N161S mutation in a Chinese kindred with epidermolytic_palmoplantar_keratoderma .
9720175	0	KRT9	50,54	keratin_9	39,48	KRT9	keratin 9	490980(Tax:9615)	490980(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and analysis of the dog keratin_9 -LRB- KRT9 -RRB- gene .
21771088	0	KRTAP1-2	68,76	keratin-associated_protein_KAP1-2	28,61	KRTAP1-2	keratin-associated protein KAP1-2	100294612(Tax:9940)	100294612(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the ovine keratin-associated_protein_KAP1-2 gene -LRB- KRTAP1-2 -RRB- .
21400094	0	KRTAP11-1	42,51	KAP11-1	28,35	KRTAP11-1	KAP11-1	100607967	16693(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of the ovine KAP11-1 gene -LRB- KRTAP11-1 -RRB- and genetic variation in its coding sequence .
25748236	0	KRas	43,47	Akt1	22,26	KRas	Akt1	16653(Tax:10090)	11651(Tax:10090)	Gene	Gene	Cooperates|nmod|START_ENTITY Cooperates|nsubj|END_ENTITY	Constitutively Active Akt1 Cooperates with KRas -LRB- G12D -RRB- to Accelerate In Vivo Pancreatic_Tumor Onset and Progression .
26457492	0	KRas	200,204	BRAF	194,198	KRas	BRAF	3845	673	Gene	Gene	oraz|compound|START_ENTITY END_ENTITY|appos|oraz	Frequency assessment of BRAF mutation , KRas mutation , and RASSF1A methylation in nodular_goitre based on fine-needle aspiration cytology specimens Ocena cz sto ci wyst powania mutacji gen w BRAF , KRas oraz .
26457492	0	KRas	200,204	BRAF	24,28	KRas	BRAF	3845	673	Gene	Gene	oraz|compound|START_ENTITY BRAF|appos|oraz gen|dobj|BRAF gen|nsubj|assessment assessment|nmod|mutation mutation|compound|END_ENTITY	Frequency assessment of BRAF mutation , KRas mutation , and RASSF1A methylation in nodular_goitre based on fine-needle aspiration cytology specimens Ocena cz sto ci wyst powania mutacji gen w BRAF , KRas oraz .
21441910	0	KSR	39,42	MEK	73,76	KSR	ERK	8844	5594	Gene	Gene	transition|nmod|START_ENTITY stimulates|nsubj|transition stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK .
9371754	0	KSR	0,3	Raf-1	15,20	KSR	Raf-1	16706(Tax:10090)	110157(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	KSR stimulates Raf-1 activity in a kinase-independent manner .
17613518	0	KSR1	76,80	ERK	40,43	KSR1	ERK	16706(Tax:10090)	26413(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Caspase-dependent cleavage disrupts the ERK cascade scaffolding function of KSR1 .
24023901	0	KSRP	60,64	DDX1	17,21	KSRP	DDX1	8570	1653	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	DEAD box protein DDX1 regulates cytoplasmic localization of KSRP .
11849592	0	KST1	41,45	SKT1	15,19	KST1	SKT1	102583546	102581965	Gene	Gene	co-expressed|nmod|START_ENTITY co-expressed|nsubjpass|END_ENTITY	The K + channel SKT1 is co-expressed with KST1 in potato guard cells -- both channels can co-assemble via their conserved KT domains .
8256512	0	KTR2	0,4	KRE2	26,30	KTR2	KRE2	853935(Tax:4932)	852094(Tax:4932)	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	KTR2 : a new member of the KRE2 mannosyltransferase gene family .
22740656	0	KU80	47,51	Terminal_deoxynucleotidyl_transferase	0,37	KU80	Terminal deoxynucleotidyl transferase	7520	1791	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Terminal_deoxynucleotidyl_transferase requires KU80 and XRCC4 to promote N-addition at non-V -LRB- D -RRB- J chromosomal breaks in non-lymphoid cells .
26065264	0	Kaiso	32,37	S100A3	1,7	Kaiso	S100A3	56805(Tax:10090)	20197(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	-LSB- S100A3 is a new target gene of Kaiso in mouse skin -RSB- .
10207085	0	Kaiso	37,42	p120	12,16	Kaiso	p120	56805(Tax:10090)	1500	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The catenin p120 -LRB- ctn -RRB- interacts with Kaiso , a novel BTB/POZ domain zinc finger transcription factor .
12087177	0	Kaiso	30,35	p120	4,8	Kaiso	p120	56805(Tax:10090)	1500	Gene	Gene	protein|nsubj|START_ENTITY partner|acl:relcl|protein END_ENTITY|dep|partner	The p120 -LRB- ctn -RRB- - binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated_CpG_dinucleotides .
17050009	0	Kaiso	74,79	p120	35,39	Kaiso	p120	56805(Tax:10090)	12388(Tax:10090)	Gene	Gene	factor|dobj|START_ENTITY factor|nsubj|ctn ctn|amod|END_ENTITY	Dancing in and out of the nucleus : p120 -LRB- ctn -RRB- and the transcription factor Kaiso .
18628310	0	Kalirin	14,21	Cdk5	25,29	Kalirin	Cdk5	84009(Tax:10116)	140908(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Kalirin by Cdk5 .
16272198	0	Kallikrein	0,10	bradykinin	21,31	Kallikrein	bradykinin	9622	3827	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|receptors receptors|amod|END_ENTITY	Kallikrein activates bradykinin B2 receptors in absence of kininogen .
23129128	0	Kallikrein-binding_protein	0,26	TNF-a	48,53	Kallikrein-binding protein	TNF-a	16625(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Kallikrein-binding_protein inhibits LPS-induced TNF-a by upregulating SOCS3 expression .
10506588	0	Kallikrein-binding_protein	0,26	growth_hormone	41,55	Kallikrein-binding protein	growth hormone	24794(Tax:10116)	81668(Tax:10116)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Kallikrein-binding_protein is induced by growth_hormone in the dwarf rat .
24430362	0	Kallikrein-related_peptidase-6	0,30	KLK6	32,36	Kallikrein-related peptidase-6	KLK6	5653	5653	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Kallikrein-related_peptidase-6 -LRB- KLK6 -RRB- mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal_adenocarcinoma .
20686372	0	Kallikrein-related_peptidase_10	0,31	KLK10	33,38	Kallikrein-related peptidase 10	KLK10	5655	5655	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Kallikrein-related_peptidase_10 -LRB- KLK10 -RRB- expression and single nucleotide polymorphisms in ovarian_cancer survival .
23201139	0	Kallikrein-related_peptidase_4	0,30	KLK4	32,36	Kallikrein-related peptidase 4	KLK4	9622	9622	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Kallikrein-related_peptidase_4 -LRB- KLK4 -RRB- mRNA predicts short-term relapse in colorectal_adenocarcinoma patients .
17804733	0	Kallikrein_6	0,12	E-cadherin	21,31	Kallikrein 6	E-cadherin	19144(Tax:10090)	999	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Kallikrein_6 induces E-cadherin shedding and promotes cell proliferation , migration , and invasion .
23647384	0	Kallikrein_6	0,12	PAR1	29,33	Kallikrein 6	PAR1	19144(Tax:10090)	14062(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Kallikrein_6 signals through PAR1 and PAR2 to promote neuron_injury and exacerbate glutamate neurotoxicity .
25014196	0	Kalrn	15,20	POMC	35,39	Kalrn	POMC	545156(Tax:10090)	18976(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning .
14996948	0	Kappa-opioid_receptor	0,21	Src	38,41	Kappa-opioid receptor	Src	4986	6714	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Kappa-opioid_receptor signals through Src and focal_adhesion_kinase to stimulate c-Jun_N-terminal_kinases in transfected COS-7 cells and human monocytic THP-1 cells .
10958688	0	Kar2p	47,52	Sls1p	0,5	Kar2p	Sls1p	853418(Tax:4932)	850830(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum .
16107877	0	Kar3	0,4	Cik1	22,26	Kar3	Cik1	856263(Tax:4932)	855238(Tax:4932)	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Kar3 interaction with Cik1 alters motor structure and function .
18753131	0	Kat1p	22,27	Hat1p	15,20	Kat1p	Hat1p	856106(Tax:4932)	856106(Tax:4932)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Involvement of Hat1p -LRB- Kat1p -RRB- catalytic activity and subcellular localization in telomeric silencing .
24361185	0	Kbtbd5	0,6	MyoD	23,27	Kbtbd5	MyoD	131377	4654	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage .
23291559	0	Kcnk1	68,73	CAR	17,20	Kcnk1	CAR	16525(Tax:10090)	12355(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY activates|dobj|gene activates|nsubj|END_ENTITY	Nuclear receptor CAR specifically activates the two-pore K + channel Kcnk1 gene in male mouse livers , which attenuates phenobarbital-induced hepatic_hyperplasia .
15891643	0	Kcnq1	29,34	Kvlqt1	36,42	Kcnq1	Kvlqt1	16535(Tax:10090)	16535(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Inner_ear_abnormalities in a Kcnq1 -LRB- Kvlqt1 -RRB- knockout mouse : a model of Jervell and Lange-Nielsen_syndrome .
18383901	0	Kdr	149,152	Flk-1	143,148	Kdr	Flk-1	3791	3791	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Laryngeal_carcinoma recurrence rate and disease-free interval are related to CD105 expression but not to vascular endothelial growth factor 2 -LRB- Flk-1 / Kdr -RRB- expression .
23660188	0	Kdx1	0,4	RCK1	15,19	Kdx1	RCK1	853696(Tax:4932)	852719(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Kdx1 regulates RCK1 gene expression by interacting with Rlm1 in Saccharomyces_cerevisiae .
18476723	0	Keap1	0,5	GST_A1	47,53	Keap1	GST A1	9817	2938	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Keap1 regulates the constitutive expression of GST_A1 during differentiation of Caco-2 cells .
16581765	0	Keap1	0,5	Neh2	15,19	Keap1	Neh2	9817	252969	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Keap1 recruits Neh2 through binding to ETGE and DLG motifs : characterization of the two-site molecular recognition model .
12145307	0	Keap1	4,9	Nrf2	65,69	Keap1	Nrf2	9817	4780	Gene	Gene	function|compound|START_ENTITY required|nsubjpass|function required|xcomp|sequester sequester|dobj|END_ENTITY	The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm .
12653965	0	Keap1	0,5	Nrf2	70,74	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|shuttling shuttling|nmod|END_ENTITY	Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles .
14585973	0	Keap1	30,35	Nrf2	87,91	Keap1	Nrf2	9817	4780	Gene	Gene	residues|nmod|START_ENTITY required|nsubjpass|residues required|nmod|ubiquitination ubiquitination|nmod|END_ENTITY	Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress .
14764898	0	Keap1	15,20	Nrf2	72,76	Keap1	Nrf2	9817	4780	Gene	Gene	Scaffolding|nmod|START_ENTITY controls|nsubj|Scaffolding controls|dobj|function function|nmod|END_ENTITY	Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes .
15282312	0	Keap1	24,29	Nrf2	118,122	Keap1	Nrf2	9817	4780	Gene	Gene	functions|compound|START_ENTITY ligase|nsubj|functions ligase|xcomp|regulate regulate|dobj|degradation degradation|nmod|END_ENTITY	Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 .
15601839	0	Keap1	12,17	Nrf2	59,63	Keap1	Nrf2	9817	4780	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin_3-Roc1 ligase .
15899855	0	Keap1	0,5	Nrf2	53,57	Keap1	Nrf2	9817	4780	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|shuttling shuttling|nmod|END_ENTITY	Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism .
16000310	0	Keap1	139,144	Nrf2	0,4	Keap1	Nrf2	9817	4780	Gene	Gene	involving|nmod|START_ENTITY pathway|acl|involving controls|nmod|pathway controls|nsubj|END_ENTITY	Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 .
16006525	0	Keap1	63,68	Nrf2	119,123	Keap1	Nrf2	9817	4780	Gene	Gene	protein|compound|START_ENTITY cysteines|nmod|protein insufficient|nsubj|cysteines insufficient|xcomp|disrupt disrupt|dobj|Neh2 Neh2|amod|binding binding|nmod|domain domain|amod|END_ENTITY	Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 .
16354693	0	Keap1	100,105	Nrf2	46,50	Keap1	Nrf2	9817	4780	Gene	Gene	activity|nmod|START_ENTITY inhibition|nmod|activity activate|nmod|inhibition activate|dobj|END_ENTITY	Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1 .
16449638	0	Keap1	91,96	Nrf2	83,87	Keap1	Nrf2	9817	4780	Gene	Gene	required|nmod|START_ENTITY required|nmod|repression repression|nmod|END_ENTITY	CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1 .
16785233	0	Keap1	74,79	Nrf2	67,71	Keap1	Nrf2	9817	4780	Gene	Gene	x|dep|START_ENTITY complex|dep|x x|dep|complex Maf|dep|x disrupting|dep|Maf disrupting|dobj|END_ENTITY	Arsenic induces NAD -LRB- P -RRB- H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer .
16888629	0	Keap1	17,22	Nrf2	23,27	Keap1	Nrf2	9817	4780	Gene	Gene	interface|amod|START_ENTITY interface|compound|END_ENTITY	Structure of the Keap1 : Nrf2 interface provides mechanistic insight into Nrf2 signaling .
16888629	0	Keap1	17,22	Nrf2	72,76	Keap1	Nrf2	9817	4780	Gene	Gene	interface|amod|START_ENTITY Structure|nmod|interface provides|nsubj|Structure provides|nmod|END_ENTITY	Structure of the Keap1 : Nrf2 interface provides mechanistic insight into Nrf2 signaling .
17127771	0	Keap1	95,100	Nrf2	49,53	Keap1	Nrf2	9817	4780	Gene	Gene	association|nmod|START_ENTITY activate|nmod|association activate|dobj|END_ENTITY	Novel n-3_fatty_acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3 .
17636022	0	Keap1	0,5	Nrf2	113,117	Keap1	Nrf2	9817	4780	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|escorting escorting|dobj|export export|nmod|END_ENTITY	Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 .
17822677	0	Keap1	14,19	Nrf2	74,78	Keap1	Nrf2	9817	4780	Gene	Gene	mutation|nmod|START_ENTITY found|nsubj|mutation found|dobj|ability ability|acl|repress repress|dobj|activity activity|amod|END_ENTITY	A mutation of Keap1 found in breast_cancer impairs its ability to repress Nrf2 activity .
18268004	0	Keap1	60,65	Nrf2	81,85	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	residues|nmod|START_ENTITY cysteine|dobj|residues cysteine|advcl|determining determining|dobj|activity activity|amod|END_ENTITY	Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity .
18316592	0	Keap1	8,13	Nrf2	33,37	Keap1	Nrf2	9817	4780	Gene	Gene	function|amod|START_ENTITY Loss|nmod|function activates|nsubj|Loss activates|dobj|END_ENTITY	Loss of Keap1 function activates Nrf2 and provides advantages for lung_cancer cell growth .
18421157	0	Keap1	113,118	Nrf2	46,50	Keap1	Nrf2	9817	4780	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|insights insights|nmod|modes modes|nmod|END_ENTITY	Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1 .
18692501	0	Keap1	22,27	Nrf2	49,53	Keap1	Nrf2	9817	4780	Gene	Gene	alteration|nmod|START_ENTITY confers|nsubj|alteration confers|dobj|activation activation|amod|END_ENTITY	Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder_cancer .
19386581	0	Keap1	119,124	Nrf2	45,49	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	knockout|amod|START_ENTITY profiles|nmod|knockout Genetic|dep|profiles Genetic|nmod|activation activation|nmod|signaling signaling|amod|END_ENTITY	Genetic versus chemoprotective activation of Nrf2 signaling : overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice .
19489739	0	Keap1	145,150	Nrf2	14,18	Keap1	Nrf2	9817	4780	Gene	Gene	151|nmod|START_ENTITY volume|nmod|151 dependent|nmod|volume dependent|nsubj|ubiquitination ubiquitination|amod|END_ENTITY	Cul3-mediated Nrf2 ubiquitination and antioxidant response element -LRB- ARE -RRB- activation are dependent on the partial molar volume at position 151 of Keap1 .
19666107	0	Keap1	12,17	Nrf2	0,4	Keap1	Nrf2	9817	4780	Gene	Gene	INrf2|appos|START_ENTITY signaling|nsubj|INrf2 END_ENTITY|parataxis|signaling	Nrf2 : INrf2 -LRB- Keap1 -RRB- signaling in oxidative stress .
19952498	0	Keap1	106,111	Nrf2	42,46	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|dobj|activation activation|nmod|END_ENTITY	Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1 .
20173742	0	Keap1	120,125	Nrf2	91,95	Keap1	Nrf2	9817	4780	Gene	Gene	inactivation|nmod|START_ENTITY transcription|nmod|inactivation transcription|dobj|END_ENTITY	The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 .
20175229	0	Keap1	44,49	Nrf2	1,5	Keap1	Nrf2	9817	4780	Gene	Gene	over-expression|amod|START_ENTITY H460-N5|nmod|over-expression H460-N5|amod|END_ENTITY	-LSB- Nrf2 down-regulated cell line H460-N5 with Keap1 over-expression increased sensitivity to anti-cancer drugs -RSB- .
20421418	0	Keap1	96,101	Nrf2	28,32	Keap1	Nrf2	9817	4780	Gene	Gene	interaction|nmod|START_ENTITY mechanism|dep|interaction mechanism|nmod|activation activation|amod|END_ENTITY	A noncanonical mechanism of Nrf2 activation by autophagy deficiency : direct interaction between Keap1 and p62 .
20486933	0	Keap1	104,109	Nrf2	45,49	Keap1	Nrf2	9817	4780	Gene	Gene	region|nmod|START_ENTITY target|dobj|region designed|xcomp|target inducers|dep|designed inducers|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of novel Nrf2 inducers designed to target the intervening region of Keap1 .
20498004	0	Keap1	64,69	Nrf2	29,33	Keap1	Nrf2	9817	4780	Gene	Gene	message|amod|START_ENTITY downregulating|dobj|message increases|advcl|downregulating increases|dobj|content content|amod|END_ENTITY	Benzo -LSB- a -RSB- pyrene increases the Nrf2 content by downregulating the Keap1 message .
20864537	0	Keap1	29,34	Nrf2	60,64	Keap1	Nrf2	9817	4780	Gene	Gene	INrf2|appos|START_ENTITY interaction|nmod|INrf2 mediates|nsubj|interaction mediates|dobj|activation activation|amod|END_ENTITY	Hsp90 interaction with INrf2 -LRB- Keap1 -RRB- mediates stress-induced Nrf2 activation .
21251164	0	Keap1	28,33	Nrf2	36,40	Keap1	Nrf2	9817	4780	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Molecular mechanisms of the Keap1 Nrf2 pathway in stress response and cancer evolution .
21651925	0	Keap1	42,47	Nrf2	69,73	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone , an electrophilic metabolite of butylated_hydroxyanisole .
21703357	0	Keap1	55,60	Nrf2	23,27	Keap1	Nrf2	117519(Tax:10116)	83619(Tax:10116)	Gene	Gene	S-nitrosylation|nmod|START_ENTITY activates|nmod|S-nitrosylation activates|dobj|END_ENTITY	Nitric_oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells .
21799073	0	Keap1	40,45	Nrf2	10,14	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	disruption|nmod|START_ENTITY Enhancing|nmod|disruption Enhancing|dobj|pathway pathway|amod|END_ENTITY	Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis .
21920027	0	Keap1	111,116	Nrf2	76,80	Keap1	Nrf2	9817	4780	Gene	Gene	required|nmod|START_ENTITY required|nsubj|analyses analyses|nmod|interaction interaction|nmod|sequence sequence|amod|END_ENTITY	Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance .
21926171	0	Keap1	48,53	Nrf2	19,23	Keap1	Nrf2	9817	4780	Gene	Gene	mRNA|amod|START_ENTITY targeting|dobj|mRNA regulates|advcl|targeting regulates|dobj|activation activation|amod|END_ENTITY	miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast_cancer cells .
22448038	0	Keap1	27,32	Nrf2	153,157	Keap1	Nrf2	9817	4780	Gene	Gene	INrf2|appos|START_ENTITY tyrosine|nsubj|INrf2 tyrosine|ccomp|controls controls|xcomp|allow allow|dobj|activation activation|amod|END_ENTITY	Antioxidant-induced INrf2 -LRB- Keap1 -RRB- tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression .
22743616	0	Keap1	0,5	Nrf2	35,39	Keap1	Nrf2	9817	4780	Gene	Gene	START_ENTITY|parataxis|kills kills|dep|END_ENTITY	Keap1 : one stone kills three birds Nrf2 , IKKb and Bcl-2 / Bcl-xL .
23274085	0	Keap1	76,81	Nrf2	18,22	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY promoting|dobj|degradation activate|advcl|promoting activate|dobj|END_ENTITY	Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver_damage .
23455180	0	Keap1	109,114	Nrf2	33,37	Keap1	Nrf2	9817	4780	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubj|study study|nmod|pathway pathway|amod|END_ENTITY	Immunohistochemical study of the Nrf2 pathway in colorectal_cancer : Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue .
23455180	0	Keap1	109,114	Nrf2	68,72	Keap1	Nrf2	9817	4780	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubj|study study|nmod|pathway pathway|dep|expression expression|amod|END_ENTITY	Immunohistochemical study of the Nrf2 pathway in colorectal_cancer : Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue .
23727018	0	Keap1	60,65	Nrf2	27,31	Keap1	Nrf2	9817	4780	Gene	Gene	deubiquitination|nmod|START_ENTITY regulates|nmod|deubiquitination regulates|dobj|END_ENTITY	USP15 negatively regulates Nrf2 through deubiquitination of Keap1 .
24489685	0	Keap1	0,5	Nrf2	72,76	Keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	cysteine|nsubj|START_ENTITY cysteine|nmod|target target|nmod|activation activation|amod|END_ENTITY	Keap1 cysteine 288 as a potential target for diallyl_trisulfide-induced Nrf2 activation .
24505412	0	Keap1	126,131	Nrf2	35,39	Keap1	Nrf2	9817	4780	Gene	Gene	dimers|amod|START_ENTITY formation|nmod|dimers mediated|nmod|formation mediated|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers .
25049078	0	Keap1	49,54	Nrf2	23,27	Keap1	Nrf2	9817	4780	Gene	Gene	controls|nmod|START_ENTITY controls|dobj|activation activation|amod|END_ENTITY	MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis .
25301875	0	Keap1	28,33	Nrf2	86,90	Keap1	Nrf2	117519(Tax:10116)	83619(Tax:10116)	Gene	Gene	modifications|nmod|START_ENTITY regulate|nsubj|modifications regulate|nmod|END_ENTITY	Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic_retinopathy .
25307732	0	Keap1	55,60	Nrf2	86,90	Keap1	Nrf2	9817	4780	Gene	Gene	Kelch-like_ECH-associated_protein_1|appos|START_ENTITY Activation|nmod|Kelch-like_ECH-associated_protein_1 Activation|parataxis|isolated isolated|nsubjpass|NF-E2-related_factor_2 NF-E2-related_factor_2|appos|END_ENTITY	Activation of the Kelch-like_ECH-associated_protein_1 -LRB- Keap1 -RRB- / NF-E2-related_factor_2 -LRB- Nrf2 -RRB- pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L. Phytochemicals able to activate the transcription factor NF-E2-related_factor_2 -LRB- Nrf2 -RRB- were isolated from an extract of Coriandrum sativum L. -LRB- C. sativum -RRB- leaves by preparative octadecyl_silica column chromatography .
25505069	0	Keap1	173,178	Nrf2	48,52	Keap1	Nrf2	9817	4780	Gene	Gene	_|nmod|START_ENTITY _|dobj|Activation Activation|compound|END_ENTITY	Kaposi 's _ Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently-Infected Endothelial Cells Through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1 .
25742418	0	Keap1	52,57	Nrf2	34,38	Keap1	Nrf2	9817	4780	Gene	Gene	Cross-Linking|compound|START_ENTITY Signaling|nmod|Cross-Linking END_ENTITY|acl|Signaling	Tetrachlorobenzoquinone Activates Nrf2 Signaling by Keap1 Cross-Linking and Ubiquitin Translocation but Not Keap1-Cullin3 Complex Dissociation .
25976679	0	Keap1	54,59	Nrf2	80,84	Keap1	Nrf2	9817	4780	Gene	Gene	INrf2|appos|START_ENTITY Downregulation|nmod|INrf2 Leads|nsubj|Downregulation Leads|nmod|END_ENTITY	Aromatase Inhibitor-Mediated Downregulation of INrf2 -LRB- Keap1 -RRB- Leads to Increased Nrf2 and Resistance in Breast_Cancer .
26012548	0	Keap1	69,74	Nrf2	22,26	Keap1	Nrf2	9817	4780	Gene	Gene	Degradation|compound|START_ENTITY Activation|dep|Degradation Activation|compound|END_ENTITY	TLR Signaling Induces Nrf2 Pathway Activation through p62 - Triggered Keap1 Degradation .
26057936	0	Keap1	20,25	Nrf2	44,48	Keap1	Nrf2	9817	4780	Gene	Gene	interactions|amod|START_ENTITY basis|nmod|interactions basis|nmod|END_ENTITY	Structural basis of Keap1 interactions with Nrf2 .
26282199	0	Keap1	49,54	Nrf2	22,26	Keap1	Nrf2	9817	4780	Gene	Gene	degradation|amod|START_ENTITY activates|nmod|degradation activates|dobj|END_ENTITY	Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation .
26282199	0	Keap1	49,54	Nrf2	22,26	Keap1	Nrf2	9817	4780	Gene	Gene	degradation|amod|START_ENTITY activates|nmod|degradation activates|dobj|END_ENTITY	Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation .
26348991	0	Keap1	51,56	Nrf2	84,88	Keap1	Nrf2	9817	4780	Gene	Gene	START_ENTITY|nmod|Affinity Affinity|nmod|END_ENTITY	Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2 : A Molecular Dynamics Simulation Study .
26381178	0	Keap1	131,136	Nrf2	73,77	Keap1	Nrf2	9817	4780	Gene	Gene	degradation|nmod|START_ENTITY promoting|dobj|degradation activates|advcl|promoting activates|dobj|END_ENTITY	PF-4708671 , a specific inhibitor of p70 ribosomal S6_kinase_1 , activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1 .
26453926	0	Keap1	47,52	Nrf2	21,25	Keap1	Nrf2	9817	4780	Gene	Gene	expression|amod|START_ENTITY targeting|dobj|expression activates|advcl|targeting activates|dobj|pathway pathway|amod|END_ENTITY	MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression .
26653613	0	Keap1	46,51	Nrf2	41,45	Keap1	Nrf2	9817	4780	Gene	Gene	interactions|amod|START_ENTITY profiling|dep|interactions profiling|nmod|inhibitors inhibitors|nmod|END_ENTITY	Thermodynamic profiling of inhibitors of Nrf2 : Keap1 interactions .
23047008	0	Keap1	61,66	Sp1	122,125	Keap1	Sp1	9817	6667	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	A possible gene silencing mechanism : hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung_cancer cells .
24630991	0	Keap1	46,51	VP24	18,22	Keap1	VP24	9817	911828(Tax:186538)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway .
21262351	0	Keap1	34,39	p65	15,18	Keap1	p65	9817	5970	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway .
11132157	0	Kel	33,36	Kell_blood_group	10,26	Kel	Kell blood group	23925(Tax:10090)	23925(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse Kell_blood_group gene -LRB- Kel -RRB- : cDNA sequence , genomic organization , expression , and enzymatic function .
11132157	0	Kell_blood_group	10,26	Kel	33,36	Kell blood group	Kel	23925(Tax:10090)	23925(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse Kell_blood_group gene -LRB- Kel -RRB- : cDNA sequence , genomic organization , expression , and enzymatic function .
7720696	0	Kem1	18,22	Sep1	10,14	Kem1	Sep1	852702(Tax:4932)	852702(Tax:4932)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role of Sep1 -LRB- = Kem1 , Xrn1 -RRB- as a microtubule-associated protein in Saccharomyces_cerevisiae .
8529461	0	Kem1	60,64	Sep1	44,48	Kem1	Sep1	852702(Tax:4932)	852702(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Identification of functional domains in the Sep1 protein -LRB- = Kem1 , Xrn1 -RRB- , which is required for transition through meiotic prophase in Saccharomyces_cerevisiae .
22580161	0	Ken	28,31	BCL6	15,19	Ken	BCL6	37785(Tax:7227)	604	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche .
22542101	0	Kendrin	0,7	separase	33,41	Kendrin	separase	5116	9700	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Kendrin is a novel substrate for separase involved in the licensing of centriole duplication .
21574054	0	Keratin_15	0,10	Hox-B13	47,54	Keratin 15	Hox-B13	3866	10481	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Keratin_15 , transcobalamin_I and homeobox gene Hox-B13 expression in breast_phyllodes_tumors : novel markers in biological classification .
26747697	0	Keratin_17	46,56	p53	0,3	Keratin 17	p53	287702(Tax:10116)	301300(Tax:10116)	Gene	Gene	Repressor|nmod|START_ENTITY Repressor|nsubj|END_ENTITY	p53 Is a Direct Transcriptional Repressor of Keratin_17 : Lessons from a Rat Model of Radiation Dermatitis .
25113562	0	Keratin_8	16,25	Piwil2	0,6	Keratin 8	Piwil2	3856	55124	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Piwil2 Inhibits Keratin_8 Degradation through Promoting p38-Induced Phosphorylation To Resist Fas-Mediated Apoptosis .
24244820	0	Keratin_8	61,70	Transglutaminase-2	110,128	Keratin 8	Transglutaminase-2	3856	7052	Gene	Gene	START_ENTITY|dobj|Phosphorylation Phosphorylation|nmod|Inhibition Inhibition|compound|END_ENTITY	Ethacrynic_Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin_8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition .
24753817	0	Keratin_8	45,54	Transglutaminase-2	108,126	Keratin 8	Transglutaminase-2	3856	7052	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin_8 Phosphorylation and Reorganization via Expression of Transglutaminase-2 .
10101018	0	Keratinocyte_growth_factor	0,26	CLC-2	38,43	Keratinocyte growth factor	CLC-2	29348(Tax:10116)	29232(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Keratinocyte_growth_factor stimulates CLC-2 expression in primary fetal rat distal lung epithelial cells .
18025186	0	Keratinocyte_growth_factor	0,26	Foxp3	70,75	Keratinocyte growth factor	Foxp3	14178(Tax:10090)	20371(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expansion expansion|nmod|cells cells|compound|END_ENTITY	Keratinocyte_growth_factor induces expansion of murine peripheral CD4 + Foxp3 + regulatory T cells and increases their thymic output .
19661335	0	Keratinocyte_growth_factor	0,26	estrogen_receptor-alpha	43,66	Keratinocyte growth factor	estrogen receptor-alpha	2252	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
22159401	0	Keratinocyte_growth_factor	0,26	matrix_metalloproteinase-9	35,61	Keratinocyte growth factor	matrix metalloproteinase-9	2252	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Keratinocyte_growth_factor induces matrix_metalloproteinase-9 expression and correlates with venous_invasion in pancreatic_cancer .
7769270	0	Keratinocyte_growth_factor	0,26	matrix_metalloproteinase-9	54,80	Keratinocyte growth factor	matrix metalloproteinase-9	2252	4318	Gene	Gene	START_ENTITY|dobj|stimulation stimulation|nmod|gelatinase gelatinase|dep|END_ENTITY	Keratinocyte_growth_factor stimulation of gelatinase -LRB- matrix_metalloproteinase-9 -RRB- and plasminogen activator in histiotypic epithelial cell culture .
12169631	0	Keren	0,5	epidermal_growth_factor_receptor	38,70	Keren	epidermal growth factor receptor	326198(Tax:7227)	37455(Tax:7227)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Keren , a new ligand of the Drosophila epidermal_growth_factor_receptor , undergoes two modes of cleavage .
18656533	0	Ketel	92,97	importin-beta	69,82	Ketel	importin-beta	35336(Tax:7227)	35336(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The DRE motif is a key component in the expression regulation of the importin-beta encoding Ketel gene in Drosophila .
15269173	0	Kette	21,26	Sra-1	0,5	Kette	Sra-1	40462(Tax:7227)	41861(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila .
17588515	0	Khd1p	75,80	ASH1	26,30	Khd1p	ASH1	852248(Tax:4932)	853650(Tax:4932)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Local activation of yeast ASH1 mRNA translation through phosphorylation of Khd1p by the casein kinase Yck1p .
20953064	0	Khd1p	58,63	MTL1	21,25	Khd1p	MTL1	852248(Tax:4932)	852905(Tax:4932)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast .
1758054	0	Ki-1	36,40	CD30	42,46	Ki-1	CD30	943	943	Gene	Gene	lymphoma|compound|START_ENTITY lymphoma|appos|END_ENTITY	-LSB- Temporary spontaneous remission in Ki-1 -LRB- CD30 -RRB- lymphoma with gastric_lesion -RSB- .
2537734	0	Ki-1	0,4	CD30	6,10	Ki-1	CD30	943	943	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Ki-1 -LRB- CD30 -RRB- antigen is released by Ki-1-positive tumor cells in vitro and in vivo .
2849300	0	Ki-1	0,4	CD30	6,10	Ki-1	CD30	943	943	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Ki-1 -LRB- CD30 -RRB- antigen is regularly expressed by tumor cells of embryonal_carcinoma .
7665144	0	Ki-1	6,10	CD30	0,4	Ki-1	CD30	943	943	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	CD30 -LRB- Ki-1 -RRB- expression in adult_T-cell_leukaemia / lymphoma is associated with distinctive immunohistological and clinical characteristics .
8390600	0	Ki-1	32,36	CD30	38,42	Ki-1	CD30	943	943	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Anaplastic_large_cell_lymphoma -LRB- Ki-1 + / CD30 + -RRB- in childhood .
9094181	0	Ki-1	48,52	CD30	54,58	Ki-1	CD30	943	943	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Carbamazepine-induced lymphadenopathy mimicking Ki-1 -LRB- CD30 + -RRB- T-cell_lymphoma .
9415340	0	Ki-1	61,65	CD30	55,59	Ki-1	CD30	943	943	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Traumatic eosinophilic_granuloma_of_the_oral_mucosa : a CD30 + -LRB- Ki-1 -RRB- lymphoproliferative_disorder ?
2169996	0	Ki-1_antigen	14,26	CD30	28,32	Ki-1 antigen	CD30	943	943	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Ki-1_antigen -LRB- CD30 -RRB- in mesenchymal_tumors .
3553214	0	Ki-RAS	10,16	p21	6,9	Ki-RAS	p21	24525(Tax:10116)	24525(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Viral p21 Ki-RAS protein : a potent intracellular mitogen that stimulates adenylate cyclase activity in early G1 phase of cultured rat cells .
15923430	0	Ki-ras	21,27	TP53	9,13	Ki-ras	TP53	3845	7157	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal_adenocarcinomas : results of a 5-year Gruppo Oncologico dell ` Italia Meridionale -LRB- GOIM -RRB- prospective study .
12503187	0	Ki-ras	59,65	c-jun	29,34	Ki-ras	c-jun	3845	3725	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of serum-induced c-jun expression by activated Ki-ras in human colon_cancer cells .
12014640	0	Ki-ras	26,32	p21	22,25	Ki-ras	p21	24525(Tax:10116)	24525(Tax:10116)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Expression of p53 and p21 Ki-ras proteins in rat thyroid gland tumors induced by 3-chloro-4 - -LRB- dichloromethyl -RRB- -5 - hydroxy-2 -LRB- 5H -RRB- - furanone -LRB- MX -RRB- .
9364215	0	Ki-ras	15,21	p21	22,25	Ki-ras	p21	3845	644914	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic_cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation .
20034543	0	KiSS-1	57,63	Insulin-like_growth_factor-1	0,28	KiSS-1	Insulin-like growth factor-1	289023(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression stimulation|amod|END_ENTITY	Insulin-like_growth_factor-1 stimulation of hypothalamic KiSS-1 gene expression is mediated by Akt : effect of alcohol .
24910643	0	KiSS-1	40,46	Leptin	14,20	KiSS-1	Leptin	289023(Tax:10116)	25608(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of Leptin and Adiponectin on KiSS-1 and KissR mRNA Expression in Rat Islets of Langerhans and CRI-D2 Cell Line .
12898236	0	KiSS-1	74,80	hOT7T175	120,128	KiSS-1	hOT7T175	3814	84634	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor -LRB- hOT7T175 -RRB- gene expression in hepatocellular_carcinoma .
14977840	0	KiSS-1	37,43	hOT7T175	83,91	KiSS-1	hOT7T175	3814	84634	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor -LRB- hOT7T175 -RRB- gene expression in esophageal_squamous_cell_carcinoma .
25375207	0	KiSS-1	82,88	kisspeptin	70,80	KiSS-1	kisspeptin	101107719	101107719	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Influences of melatonin treatment , melatonin_receptor_1A -LRB- MTNR1A -RRB- and kisspeptin -LRB- KiSS-1 -RRB- gene polymorphisms on first conception in Sarda ewe lambs .
16503925	0	KiSS-1	0,6	leptin	39,45	KiSS-1	leptin	280287(Tax:10090)	16846(Tax:10090)	Gene	Gene	neurones|amod|START_ENTITY targets|nsubj|neurones targets|nmod|END_ENTITY	KiSS-1 neurones are direct targets for leptin in the ob/ob mouse .
23049591	0	KiSS-1	39,45	leptin	10,16	KiSS-1	Leptin	280287(Tax:10090)	16846(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|Excess Excess|nmod|END_ENTITY	Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice .
8944003	0	KiSS-1	0,6	malignant_melanoma_metastasis-suppressor	22,62	KiSS-1	malignant melanoma metastasis-suppressor	3814	3814	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	KiSS-1 , a novel human malignant_melanoma_metastasis-suppressor gene .
16964286	0	KiSS-1	30,36	specificity_protein-1	79,100	KiSS-1	specificity protein-1	3814	6667	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity_protein-1 and its coactivator DRIP-130 .
11323438	0	Kidney_androgen-regulated_protein	0,33	cyclophilin_B	49,62	Kidney androgen-regulated protein	cyclophilin B	16483(Tax:10090)	19035(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Kidney_androgen-regulated_protein interacts with cyclophilin_B and reduces cyclosporine_A-mediated toxicity in proximal tubule cells .
19818618	0	Kif15	0,5	eg5	22,25	Kif15	eg5	56992	3832	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Kif15 cooperates with eg5 to promote bipolar spindle assembly .
21737685	0	Kif18B	0,6	EB1	22,25	Kif18B	EB1	146909	22919	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Kif18B interacts with EB1 and controls astral microtubule length during mitosis .
21620453	0	Kif24	19,24	CP110	40,45	Kif24	CP110	347240	9738	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Centriolar kinesin Kif24 interacts with CP110 to remodel microtubules and regulate ciliogenesis .
26290419	0	Kif24	19,24	Nek2	0,4	Kif24	Nek2	347240	4751	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle .
26290419	0	Kif24	19,24	Nek2	0,4	Kif24	Nek2	347240	4751	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle .
18411309	0	Kif2a	39,44	DDA3	0,4	Kif2a	DDA3	3796	84722	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement .
22535524	0	Kif2b	38,43	Plk1	0,4	Kif2b	Plk1	84643	5347	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation .
23034632	0	Kif7	0,4	Gli2	15,19	Kif7	Gli2	374654	2736	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Kif7 regulates Gli2 through Sufu-dependent and - independent functions during skin development and tumorigenesis .
25205074	0	Killer_Cell_Immunoglobulin-like_Receptor	13,53	KIR	55,58	Killer Cell Immunoglobulin-like Receptor	KIR	3806	3806	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Diversity of Killer_Cell_Immunoglobulin-like_Receptor -LRB- KIR -RRB- genes in the Bengali population of Northern West Bengal , India .
22139069	0	Killer_Ig-Like_Receptors	49,73	KIR	75,78	Killer Ig-Like Receptors	KIR	3805	3805	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	Differential impact of inhibitory and activating Killer_Ig-Like_Receptors -LRB- KIR -RRB- on high-risk patients with myeloid and lymphoid_malignancies undergoing reduced intensity transplantation from haploidentical related donors .
20082621	0	Killer_cell_immunoglobulin-like_receptor	0,40	KIR	42,45	Killer cell immunoglobulin-like receptor	KIR	3806	3806	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genes in systemic_sclerosis .
24131019	0	Killer_cell_immunoglobulin-like_receptor	20,60	KIR	62,65	Killer cell immunoglobulin-like receptor	KIR	3806	3806	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of Killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genotypes and haplotypes in Chinese Han population .
23549267	0	Kinase_Activation_and_Tumor_Necrosis_Factor-Alpha	78,127	p38	48,51	Kinase Activation and Tumor Necrosis Factor-Alpha	p38	7124	1432	Gene	Gene	Expression|compound|START_ENTITY Expression|amod|END_ENTITY	A Role for Protein Phosphatase 2A in Regulating p38 Mitogen Activated Protein Kinase_Activation_and_Tumor_Necrosis_Factor-Alpha Expression during Influenza Virus_Infection .
22408460	0	Kinase_Insert_Domain_Receptor	48,77	KDR	79,82	Kinase Insert Domain Receptor	KDR	3791	3791	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Pyrrolo -LSB- 3,2-d -RSB- pyrimidine Derivatives as Type II Kinase_Insert_Domain_Receptor -LRB- KDR -RRB- Inhibitors : CoMFA and CoMSIA Studies .
20865788	0	Kinase_suppressor_of_Ras_1	0,26	ERK	48,51	Kinase suppressor of Ras 1	ERK	16706(Tax:10090)	26413(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Kinase_suppressor_of_Ras_1 is required for full ERK activation in thymocytes but not for thymocyte selection .
21518958	0	Kinase_suppressor_of_ras_1	0,26	PGC1a	44,49	Kinase suppressor of ras 1	PGC1a	16706(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Kinase_suppressor_of_ras_1 -LRB- KSR1 -RRB- regulates PGC1a and estrogen-related receptor a to promote oncogenic Ras-dependent anchorage-independent growth .
25237194	0	Kindlin-2	0,9	Src	56,59	Kindlin-2	Src	218952(Tax:10090)	20779(Tax:10090)	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|Serve Serve|compound|END_ENTITY	Kindlin-2 Tyrosine Phosphorylation and Interaction with Src Serve as a Regulatable Switch in the Integrin_Outside-in Signaling Circuit .
26037143	0	Kindlin-2	0,9	Src	29,32	Kindlin-2	Src	10979	6714	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions .
26037143	0	Kindlin-2	0,9	Src	50,53	Kindlin-2	Src	10979	6714	Gene	Gene	phosphorylation|amod|START_ENTITY enhances|nsubj|phosphorylation enhances|dobj|activity activity|compound|END_ENTITY	Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions .
25807898	0	Kindlin-3	56,65	EMMPRIN	0,7	Kindlin-3	EMMPRIN	83706	682	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	EMMPRIN regulates b1 integrin-mediated adhesion through Kindlin-3 in human melanoma cells .
23717433	0	Kindlin_2	0,9	myogenin	44,52	Kindlin 2	myogenin	218952(Tax:10090)	17928(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Kindlin_2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation .
12403717	0	Kinesin	0,7	Kinesin_heavy_chain	48,67	Kinesin	Kinesin heavy chain	36810(Tax:7227)	36810(Tax:7227)	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Kinesin light chain-independent function of the Kinesin_heavy_chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte .
20630947	0	Kinesin-1	32,41	PAT1	11,15	Kinesin-1	PAT1	36810(Tax:7227)	31593(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility .
19451621	0	Kinesin-Associated_Protein_3	26,54	KIFAP3	56,62	Kinesin-Associated Protein 3	KIFAP3	22920	22920	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Reduced expression of the Kinesin-Associated_Protein_3 -LRB- KIFAP3 -RRB- gene increases survival in sporadic amyotrophic_lateral_sclerosis .
25063455	0	Kinesin-II	0,10	Armadillo	20,29	Kinesin-II	Armadillo	39332(Tax:7227)	31151(Tax:7227)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Kinesin-II recruits Armadillo and Dishevelled for Wingless signaling in Drosophila .
26843789	0	Kinesin_Associated_Protein_3	18,46	KIFAP3	48,54	Kinesin Associated Protein 3	KIFAP3	22920	22920	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Kinesin_Associated_Protein_3 -LRB- KIFAP3 -RRB- in Breast_Cancer .
22766233	0	Kinesin_family_member_26B	95,120	Abelson_interactor_protein_1	33,61	Kinesin family member 26B	Abelson interactor protein 1	55083	10006	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The postsynaptic density protein Abelson_interactor_protein_1 interacts with the motor protein Kinesin_family_member_26B in hippocampal neurons .
12403717	0	Kinesin_heavy_chain	48,67	Kinesin	0,7	Kinesin heavy chain	Kinesin	36810(Tax:7227)	36810(Tax:7227)	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Kinesin light chain-independent function of the Kinesin_heavy_chain in cytoplasmic streaming and posterior localisation in the Drosophila oocyte .
20833961	0	Kinin_B1_receptor	0,17	angiotensin_II	34,48	Kinin B1 receptor	angiotensin II	81509(Tax:10116)	24179(Tax:10116)	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Kinin_B1_receptor upregulation by angiotensin_II and endothelin-1 in rat vascular smooth muscle cells : receptors and mechanisms .
3038783	0	Kininase_I	0,10	kininase_II	12,23	Kininase I	kininase II	1369	1636	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Kininase_I , kininase_II and aminopeptidase levels in patients with gastrointestinal_tumors .
20423613	0	Kip-related_protein_4	14,35	KRP4	42,46	Kip-related protein 4	KRP4	817831(Tax:3702)	817831(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY Expression|nmod|gene Expression|appos|END_ENTITY	Expression of Kip-related_protein_4 gene -LRB- KRP4 -RRB- in response to auxin and cytokinin during growth of Arabidopsis_thaliana .
11118465	0	Kip1	35,39	BRCA1/2	9,16	Kip1	BRCA1/2	1027	672;675	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Germline BRCA1/2 mutations and p27 -LRB- Kip1 -RRB- protein levels independently predict outcome after breast_cancer .
24806449	0	Kip1	67,71	DYRK1A	41,47	Kip1	DYRK1A	12576(Tax:10090)	13548(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The Down syndrome-related protein kinase DYRK1A phosphorylates p27 -LRB- Kip1 -RRB- and Cyclin_D1 and induces cell cycle exit and neuronal differentiation .
10198259	0	Kip1	57,61	Interleukin-6	0,13	Kip1	Interleukin-6	1027	3569	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	Interleukin-6 induces G1 arrest through induction of p27 -LRB- Kip1 -RRB- , a cyclin-dependent kinase inhibitor , and neuron-like morphology in LNCaP prostate_tumor cells .
12782606	0	Kip1	123,127	Jun_activation_domain-binding_protein_1	0,39	Kip1	Jun activation domain-binding protein 1	1027	10987	Gene	Gene	p27|appos|START_ENTITY correlates|nmod|p27 correlates|nsubj|expression expression|amod|END_ENTITY	Jun_activation_domain-binding_protein_1 expression in breast_cancer inversely correlates with the cell cycle inhibitor p27 -LRB- Kip1 -RRB- .
16175894	0	Kip1	63,67	Jun_activation_domain-binding_protein_1	14,53	Kip1	Jun activation domain-binding protein 1	1027	10987	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Jun_activation_domain-binding_protein_1 and p27 -LRB- Kip1 -RRB- in thyroid medullary_carcinoma .
22856547	0	Kip1	68,72	MT1	10,13	Kip1	MT1	1027	644314	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|compound|END_ENTITY	Melatonin MT1 receptor-induced transcriptional up-regulation of p27 -LRB- Kip1 -RRB- in prostate_cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B -LRB- NF-kB -RRB- : potential implications on prostate_cancer chemoprevention and therapy .
17534820	0	Kip1	31,35	P27	27,30	Kip1	P27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	alterations|appos|START_ENTITY alterations|nmod|END_ENTITY	Optic nerve alterations in P27 -LRB- Kip1 -RRB- knockout mice .
21236467	0	Kip1	101,105	Pirh2	14,19	Kip1	Pirh2	1027	25898	Gene	Gene	correlation|nmod|START_ENTITY Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	Kip1	27,31	Pirh2	14,19	Kip1	Pirh2	1027	25898	Gene	Gene	ligase|appos|START_ENTITY Expression|appos|ligase Expression|nmod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
16289056	0	Kip1	48,52	Prointerleukin-16	22,39	Kip1	Prointerleukin-16	1027	3603	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of nuclear Prointerleukin-16 and p27 -LRB- Kip1 -RRB- in primary human T lymphocytes .
10375532	0	Kip1	4,8	Skp2	65,69	Kip1	Skp2	1027	6502	Gene	Gene	ubiquitination|appos|START_ENTITY regulated|nsubjpass|ubiquitination regulated|nmod|complex complex|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
11335900	0	Kip1	39,43	Skp2	81,85	Kip1	Skp2	1027	6502	Gene	Gene	p27|appos|START_ENTITY levels|nmod|p27 relation|nmod|levels ligase|nsubj|relation ligase|dobj|END_ENTITY	Inverse relation between levels of p27 -LRB- Kip1 -RRB- and of its ubiquitin ligase subunit Skp2 in colorectal_carcinomas .
12351407	0	Kip1	26,30	Skp2	14,18	Kip1	Skp2	1027	6502	Gene	Gene	ligase|appos|START_ENTITY Expression|appos|ligase Expression|nmod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	Kip1	94,98	Skp2	14,18	Kip1	Skp2	1027	6502	Gene	Gene	correlation|nmod|START_ENTITY Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
16209941	0	Kip1	58,62	Skp2	75,79	Kip1	Skp2	1027	6502	Gene	Gene	START_ENTITY|nmod|ubiquitin ubiquitin|appos|END_ENTITY	Structural basis of the Cks1-dependent recognition of p27 -LRB- Kip1 -RRB- by the SCF -LRB- Skp2 -RRB- ubiquitin ligase .
17384652	0	Kip1	73,77	Skp2	0,4	Kip1	Skp2	1027	6502	Gene	Gene	p27|appos|START_ENTITY gallbladder_carcinoma|nmod|p27 prognosticator|nmod|gallbladder_carcinoma prognosticator|nsubj|END_ENTITY	Skp2 is an independent prognosticator of gallbladder_carcinoma among p27 -LRB- Kip1 -RRB- - interacting cell cycle regulators : an immunohistochemical study of 62 cases by tissue microarray .
19724954	0	Kip1	41,45	Skp2	28,32	Kip1	Skp2	1027	6502	Gene	Gene	correlation|appos|START_ENTITY correlation|nmod|END_ENTITY	Inverse correlation between Skp2 and p27 -LRB- Kip1 -RRB- in normal endometrium and endometrial_carcinoma .
21299246	0	Kip1	133,137	Skp2	139,143	Kip1	Skp2	1027	6502	Gene	Gene	p27|appos|START_ENTITY p27|dep|complex complex|dep|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21299246	0	Kip1	95,99	Skp2	139,143	Kip1	Skp2	1027	6502	Gene	Gene	START_ENTITY|acl|attributed attributed|nmod|disruption disruption|nmod|p27 p27|dep|complex complex|dep|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
23474082	0	Kip1	72,76	Skp2	0,4	Kip1	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	accumulation|appos|START_ENTITY independent|nmod|accumulation inhibits|xcomp|independent inhibits|nsubj|deficiency deficiency|amod|END_ENTITY	Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27 -LRB- Kip1 -RRB- accumulation .
26682002	0	Kip1	44,48	Skp2	107,111	Kip1	Skp2	1027	6502	Gene	Gene	p27|appos|START_ENTITY Increase|dobj|p27 Increase|advcl|Affecting Affecting|nmod|Downregulation Downregulation|compound|END_ENTITY	Histone Deacetylase Inhibitors Increase p27 -LRB- Kip1 -RRB- by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation .
26298725	0	Kip1	141,145	TRIP6	18,23	Kip1	TRIP6	1027	7205	Gene	Gene	p27|appos|START_ENTITY expression|nsubj|p27 regulating|xcomp|expression promotes|advcl|regulating promotes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance -LRB- CAM-DR -RRB- via regulating nuclear p27 -LRB- Kip1 -RRB- expression in non-Hodgkin 's _ lymphoma .
11749217	0	Kip1	90,94	c-Fos	76,81	Kip1	c-Fos	1027	2353	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Effects of macromolecular crowding on the intrinsically disordered proteins c-Fos and p27 -LRB- Kip1 -RRB- .
19397698	0	Kip1	164,168	cIAP-1	143,149	Kip1	cIAP-1	1027	329	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Human_papillomavirus_16 E6/E7-immortalized human gingival keratinocytes with epithelial mesenchymal transition acquire increased expression of cIAP-1 , Bclx and p27 -LRB- Kip1 -RRB- .
12370811	0	Kip1	41,45	cyclin_D2	23,32	Kip1	cyclin D2	12576(Tax:10090)	12444(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Functional analysis of cyclin_D2 and p27 -LRB- Kip1 -RRB- in cyclin_D2 transgenic mouse mammary gland during development .
12393444	0	Kip1	134,138	p21	116,119	Kip1	p21	12576(Tax:10090)	12575(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	GATA-2 / estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21 -LRB- WAF1 -RRB- and p27 -LRB- Kip1 -RRB- proteins .
10318797	0	Kip1	23,27	p27	19,22	Kip1	p27	1027	10671	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of p27 -LRB- Kip1 -RRB- by two mechanisms , ubiquitin-mediated degradation and proteolytic processing .
10361114	0	Kip1	42,46	p27	38,41	Kip1	p27	1027	10534	Gene	Gene	cyclin-dependent|appos|START_ENTITY cyclin-dependent|amod|END_ENTITY	Expression of p21 -LRB- Cip1/Waf1/Sdi1 -RRB- and p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitors during human hematopoiesis .
10375532	0	Kip1	4,8	p27	0,3	Kip1	p27	1027	10671	Gene	Gene	ubiquitination|appos|START_ENTITY ubiquitination|amod|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
10375532	0	Kip1	4,8	p27	112,115	Kip1	p27	1027	10671	Gene	Gene	ubiquitination|appos|START_ENTITY regulated|nsubjpass|ubiquitination regulated|nmod|complex complex|nmod|Thr187 Thr187|nmod|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
10398135	0	Kip1	31,35	p27	27,30	Kip1	p27	1027	3429	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of p27 -LRB- Kip1 -RRB- expression in colorectal_cancer : a clinico-pathological characterization .
10490638	0	Kip1	70,74	p27	66,69	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Targeted disruption of CDK4 delays cell cycle entry with enhanced p27 -LRB- Kip1 -RRB- activity .
10491517	0	Kip1	26,30	p27	22,25	Kip1	p27	1027	10671	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Reduced expression of p27 -LRB- Kip1 -RRB- protein in relation to salivary adenoid cystic carcinoma metastasis .
10534337	0	Kip1	14,18	p27	10,13	Kip1	p27	1027	3429	Gene	Gene	influence|dep|START_ENTITY influence|nsubj|END_ENTITY	Decreased p27 -LRB- Kip1 -RRB- expression and cyclin_D1 overexpression , alone and in combination , influence recurrence and survival of patients with resectable extrahepatic_bile_duct_carcinoma .
10542271	0	Kip1	75,79	p27	71,74	Kip1	p27	1027	3429	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Sp1 and NF-Y synergistically mediate the effect of vitamin_D -LRB- 3 -RRB- in the p27 -LRB- Kip1 -RRB- gene promoter that lacks vitamin_D response elements .
10662779	0	Kip1	31,35	p27	27,30	Kip1	p27	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differential regulation of p27 -LRB- Kip1 -RRB- expression by mitogenic and hypertrophic factors : Involvement of transcriptional and posttranscriptional mechanisms .
10694472	0	Kip1	28,32	p27	24,27	Kip1	p27	1027	10671	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Activation of the human p27 -LRB- Kip1 -RRB- promoter by IFNalpha 2b .
10704741	0	Kip1	38,42	p27	34,37	Kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- expression in transitional cell carcinoma_of_renal_pelvis_and_ureter .
10796881	0	Kip1	4,8	p27	0,3	Kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p27 -LRB- Kip1 -RRB- expression in normal epithelia , precancerous_lesions , and carcinomas of the gallbladder : association with cancer progression and prognosis .
10888749	0	Kip1	38,42	p27	34,37	Kip1	p27	1027	10671	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- expression in thyroid cells obtained by fine-needle aspiration biopsy : a preliminary report .
10942583	0	Kip1	30,34	p27	26,29	Kip1	p27	1027	10671	Gene	Gene	Accumulation|appos|START_ENTITY Accumulation|nmod|form form|nmod|END_ENTITY	Accumulation of a form of p27 -LRB- Kip1 -RRB- not associated with Cdk-cyclin complexes in transforming_growth_factor-beta-arrested Mv1Lu cells .
10942583	1	Kip1	316,320	p27	312,315	Kip1	p27	1027	10671	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor translocates in response to transforming_growth_factor-beta to a Cdk2-cyclin E complex inhibiting its catalytic activity , but the p27 -LRB- Kip1 -RRB- protein levels are unaffected -LSB- 1 -RSB- .
11080613	0	Kip1	29,33	p27	25,28	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Changes in p21 -LRB- Cip1 -RRB- and p27 -LRB- Kip1 -RRB- expression are not required for cell cycle entry and progression to S phase in Swiss_3T3 cells .
11159883	0	Kip1	12,16	p27	8,11	Kip1	p27	1027	10671	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of p27 -LRB- Kip1 -RRB- in human intestinal cell differentiation .
11160939	0	Kip1	76,80	p27	72,75	Kip1	p27	100689401	10534	Gene	Gene	sense|appos|START_ENTITY sense|amod|END_ENTITY	Streptogramin - and tetracycline-responsive dual regulated expression of p27 -LRB- Kip1 -RRB- sense and antisense enables positive and negative growth control of Chinese_hamster_ovary cells .
11266285	0	Kip1	32,36	p27	28,31	Kip1	p27	1027	10534	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Anomalous overexpression of p27 -LRB- Kip1 -RRB- in sporadic_pancreatic_endocrine_tumors .
11313917	0	Kip1	39,43	p27	35,38	Kip1	p27	1027	10534	Gene	Gene	cyclin-dependent|appos|START_ENTITY cyclin-dependent|amod|END_ENTITY	Repression of transcription of the p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor gene by c-Myc .
11353044	0	Kip1	18,22	p27	14,17	Kip1	p27	1027	3429	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of p27 -LRB- Kip1 -RRB- protein in transitional cell carcinoma of the upper urinary tract .
11400230	0	Kip1	22,26	p27	18,21	Kip1	p27	1027	10671	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Low expression of p27 -LRB- Kip1 -RRB- in advanced mucoepidermoid_carcinomas of head and neck .
11400230	9	Kip1	1567,1571	p27	1563,1566	Kip1	p27	1027	10671	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Also patients with low p27 -LRB- Kip1 -RRB- expression showed poor prognosis -LRB- p = .002 -RRB- .
11413088	0	Kip1	13,17	p27	9,12	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role for p27 -LRB- Kip1 -RRB- in Vascular Smooth Muscle Cell Migration .
11466560	0	Kip1	27,31	p27	23,26	Kip1	p27	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II induces p27 -LRB- Kip1 -RRB- expression in renal tubules in vivo : role of reactive oxygen species .
11527971	0	Kip1	46,50	p27	42,45	Kip1	p27	1027	10671	Gene	Gene	deregulation|appos|START_ENTITY deregulation|amod|END_ENTITY	Constitutive MEK/MAPK activation leads to p27 -LRB- Kip1 -RRB- deregulation and antiestrogen resistance in human breast_cancer cells .
11557117	0	Kip1	47,51	p27	43,46	Kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of cell-cycle regulator p27 -LRB- Kip1 -RRB- correlates with a shortened survival in non-small_cell_lung_cancer .
11557735	0	Kip1	102,106	p27	98,101	Kip1	p27	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27 -LRB- Kip1 -RRB- expression in the vasculature of hypertensive rats .
11579684	0	Kip1	37,41	p27	32,35	Kip1	p27	1027	3429	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Immunohistochemical analysis of p27 -LRB- Kip1 -RRB- in human pituitary glands and in various types of pituitary_adenomas .
11590147	0	Kip1	95,99	p27	91,94	Kip1	p27	1027	10671	Gene	Gene	association|appos|START_ENTITY association|amod|END_ENTITY	Cyclin_D1 overexpression induces progestin resistance in T-47D breast_cancer cells despite p27 -LRB- Kip1 -RRB- association with cyclin E-Cdk2 .
11716548	0	Kip1	37,41	p27	33,36	Kip1	p27	1027	10534	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Transcriptional up-regulation of p27 -LRB- Kip1 -RRB- during contact-induced growth_arrest in vascular endothelial cells .
11753978	0	Kip1	43,47	p27	39,42	Kip1	p27	1027	10671	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the cell cycle regulator p27 -LRB- Kip1 -RRB- in normal squamous epithelium , cervical_intraepithelial_neoplasia , and invasive squamous_cell_carcinoma_of_the_uterine_cervix .
11854065	0	Kip1	23,27	p27	19,22	Kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic role of p27 -LRB- Kip1 -RRB- expression in oral_squamous_cell_carcinoma in Taiwan .
12146978	0	Kip1	22,26	p27	18,21	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	ACTH promotion of p27 -LRB- Kip1 -RRB- induction in mouse Y1 adrenocortical_tumor cells is dependent on both PKA activation and Akt/PKB inactivation .
12149143	0	Kip1	38,42	p27	34,37	Kip1	p27	1027	10534	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Troglitazone induces G1_arrest by p27 -LRB- Kip1 -RRB- induction that is mediated by inhibition of proteasome in human gastric_cancer cells .
12351407	0	Kip1	26,30	p27	22,25	Kip1	p27	1027	10671	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	Kip1	26,30	p27	90,93	Kip1	p27	1027	10671	Gene	Gene	ligase|appos|START_ENTITY Expression|appos|ligase Expression|dep|correlation correlation|nmod|Kip1 Kip1|amod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	Kip1	94,98	p27	22,25	Kip1	p27	1027	10671	Gene	Gene	correlation|nmod|START_ENTITY Expression|dep|correlation Expression|appos|ligase ligase|amod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12451619	0	Kip1	17,21	p27	13,16	Kip1	p27	1027	10534	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Low level of p27 -LRB- Kip1 -RRB- protein expression in gastric_adenocarcinoma is associated with disease progression and poor outcome .
12700629	0	Kip1	14,18	p27	10,13	Kip1	p27	1027	10534	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Inducible p27 -LRB- Kip1 -RRB- expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors .
12776284	0	Kip1	43,47	p27	39,42	Kip1	p27	1027	3429	Gene	Gene	cyclin-dependent|appos|START_ENTITY cyclin-dependent|amod|END_ENTITY	Increased expression of p16 -LRB- INK4a -RRB- and p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor genes in aging human kidney and chronic_allograft_nephropathy .
14654548	0	Kip1	78,82	p27	74,77	Kip1	p27	1027	3429	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Jun_activation_domain_binding_protein_1 expression is associated with low p27 -LRB- Kip1 -RRB- levels in node-negative breast_cancer .
14977358	0	Kip1	18,22	p27	14,17	Kip1	p27	1027	10671	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of p27 -LRB- Kip1 -RRB- by intracellular iron levels .
15075339	0	Kip1	4,8	p27	0,3	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	stabilization|appos|START_ENTITY stabilization|amod|END_ENTITY	p27 -LRB- Kip1 -RRB- stabilization and G -LRB- 1 -RRB- arrest by 1,25-dihydroxyvitamin _ D -LRB- 3 -RRB- in ovarian_cancer cells mediated through down-regulation of cyclin E/cyclin-dependent _ kinase_2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase .
15110991	0	Kip1	16,20	p27	12,15	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of p27 -LRB- Kip1 -RRB- in maintaining the levels of D-type cyclins in vivo .
15176022	0	Kip1	4,8	p27	0,3	Kip1	p27	1027	10671	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p27 -LRB- Kip1 -RRB- expression and grading of breast_cancer diagnosed on cytological samples .
15568022	0	Kip1	18,22	p27	14,17	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Protection of p27 -LRB- Kip1 -RRB- mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation .
16135812	0	Kip1	72,76	p27	68,71	Kip1	p27	1027	10534	Gene	Gene	mislocalization|appos|START_ENTITY mislocalization|amod|END_ENTITY	Pathway - and expression level-dependent effects of oncogenic N-Ras : p27 -LRB- Kip1 -RRB- mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling .
16359379	0	Kip1	141,145	p27	137,140	Kip1	p27	1027	3429	Gene	Gene	cyclin-dependent|appos|START_ENTITY cyclin-dependent|amod|END_ENTITY	Up-regulation of cell cycle regulatory genes after renal_ischemia / reperfusion : differential expression of p16 -LRB- INK4a -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor genes depending on reperfusion time .
16489017	0	Kip1	27,31	p27	23,26	Kip1	p27	1027	10534	Gene	Gene	Reduction|appos|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of cytosolic p27 -LRB- Kip1 -RRB- inhibits cancer cell motility , survival , and tumorigenicity .
16528608	0	Kip1	16,20	p27	12,15	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of p27 -LRB- Kip1 -RRB- expression in insulinomas developed in pancreatic beta-cell specific Men1 mutant mice .
16972266	0	Kip1	106,110	p27	102,105	Kip1	p27	1027	10671	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Extracellular adenosine_triphosphate protects oxidative stress-induced increase of p21 -LRB- WAF1/Cip1 -RRB- and p27 -LRB- Kip1 -RRB- expression in primary cultured renal proximal tubule cells : role of PI3K and Akt signaling .
17216128	0	Kip1	94,98	p27	90,93	Kip1	p27	1027	10671	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27 -LRB- Kip1 -RRB- induction .
17310312	0	Kip1	12,16	p27	8,11	Kip1	p27	1027	10534	Gene	Gene	CDKI|appos|START_ENTITY CDKI|compound|END_ENTITY	Loss of p27 -LRB- Kip1 -RRB- CDKI is a predictor of poor recurrence-free and cancer-specific survival in patients with renal_cancer .
17356514	0	Kip1	104,108	p27	100,103	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Defects in retinal_pigment_epithelium cell proliferation and retinal attachment in mutant mice with p27 -LRB- Kip1 -RRB- gene ablation .
17577273	0	Kip1	8,12	p27	4,7	Kip1	p27	1027	3429	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Low p27 -LRB- Kip1 -RRB- expression is associated with poor prognostic factors in breast_carcinomas .
17627278	0	Kip1	22,26	p27	18,21	Kip1	p27	1027	10534	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Regulation of the p27 -LRB- Kip1 -RRB- tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation .
18075313	0	Kip1	28,32	p27	24,27	Kip1	p27	1027	3429	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Multiple mechanisms for p27 -LRB- Kip1 -RRB- translocation and degradation .
18311148	0	Kip1	87,91	p27	83,86	Kip1	p27	1027	3429	Gene	Gene	stability|appos|START_ENTITY stability|amod|END_ENTITY	Protein kinase CK2 links extracellular growth factor signaling with the control of p27 -LRB- Kip1 -RRB- stability in the heart .
18566599	0	Kip1	54,58	p27	50,53	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The death domain-containing kinase RIP1 regulates p27 -LRB- Kip1 -RRB- levels through the PI3K-Akt-forkhead pathway .
19066472	0	Kip1	49,53	p27	45,48	Kip1	p27	1027	10671	Gene	Gene	tyrosine|appos|START_ENTITY tyrosine|amod|END_ENTITY	Tyrosine phosphatase SHP-2 is a regulator of p27 -LRB- Kip1 -RRB- tyrosine phosphorylation .
19077036	0	Kip1	25,29	p27	21,24	Kip1	p27	1027	10671	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	E2F-like elements in p27 -LRB- Kip1 -RRB- promoter specifically sense deregulated E2F activity .
19079342	0	Kip1	50,54	p27	46,49	Kip1	p27	1027	3429	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Id-1 activates Akt-mediated Wnt signaling and p27 -LRB- Kip1 -RRB- phosphorylation through PTEN inhibition .
19451650	4	Kip1	855,859	p27	851,854	Kip1	p27	1027	10671	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	Experiments with BGLF4 knockdown by small interfering RNA and BGLF4 knock-out viruses clarified that EBV PK is involved in p27 -LRB- Kip1 -RRB- degradation upon lytic replication .
19513905	0	Kip1	136,140	p27	132,135	Kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27 -LRB- Kip1 -RRB- expression .
19672859	0	Kip1	53,57	p27	49,52	Kip1	p27	1027	3429	Gene	Gene	reduction|appos|START_ENTITY reduction|nmod|END_ENTITY	The reduction of cell death and proliferation by p27 -LRB- Kip1 -RRB- minimizes DNA damage in an experimental model of genotoxicity .
19866239	0	Kip1	171,175	p27	166,169	Kip1	p27	1027	3429	Gene	Gene	turnover|appos|START_ENTITY turnover|dep|prognosticator prognosticator|nmod|END_ENTITY	CKS1B overexpression implicates clinical aggressiveness_of_hepatocellular_carcinomas but not p27 -LRB- Kip1 -RRB- protein turnover : an independent prognosticator with potential p27 -LRB- Kip1 -RRB- - independent oncogenic attributes ?
19959471	0	Kip1	28,32	p27	24,27	Kip1	p27	1027	10671	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mitogenic regulation of p27 -LRB- Kip1 -RRB- gene is mediated by AP-1 transcription factors .
20170512	0	Kip1	45,49	p27	41,44	Kip1	p27	1027	10671	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upstream molecular signaling pathways of p27 -LRB- Kip1 -RRB- expression : effects of 4-hydroxytamoxifen , dexamethasone , and retinoic_acids .
20356461	0	Kip1	80,84	p27	76,79	Kip1	p27	1027	3429	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Novel p104 protein regulates cell proliferation through PI3K inhibition and p27 -LRB- Kip1 -RRB- expression .
20837141	0	Kip1	24,28	p27	20,23	Kip1	p27	1027	10671	Gene	Gene	stability|appos|START_ENTITY stability|amod|END_ENTITY	Cyclin_D1 regulates p27 -LRB- Kip1 -RRB- stability in B cells .
20837141	4	Kip1	534,538	p27	530,533	Kip1	p27	1027	10671	Gene	Gene	phosphorylated|appos|START_ENTITY phosphorylated|amod|END_ENTITY	But , only the p27 -LRB- Kip1 -RRB- form phosphorylated on serine 10 -LRB- pSer10-p27 -LRB- Kip1 -RRB- -RRB- accumulates in BD1-9 cells .
20935455	0	Kip1	78,82	p27	74,77	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Oct1 is required for mTOR-induced G1 cell cycle arrest via the control of p27 -LRB- Kip1 -RRB- expression .
21067268	0	Kip1	16,20	p27	12,15	Kip1	p27	1027	10534	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of p27 -LRB- Kip1 -RRB- phosphorylation at serine 10 in the migration of malignant_glioma cells in vitro .
21216562	0	Kip1	52,56	p27	47,50	Kip1	p27	1027	10534	Gene	Gene	Ser|appos|START_ENTITY Ser|amod|END_ENTITY	Variation of gene expression profile linked to p27 -LRB- Kip1 -RRB- Ser -LRB- 10 -RRB- phosphorylation status in MCF-7 cell line .
21236467	0	Kip1	101,105	p27	23,26	Kip1	p27	1027	3429	Gene	Gene	correlation|nmod|START_ENTITY Expression|dep|correlation Expression|appos|ligase ligase|amod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	Kip1	27,31	p27	23,26	Kip1	p27	1027	3429	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	Kip1	27,31	p27	97,100	Kip1	p27	1027	3429	Gene	Gene	ligase|appos|START_ENTITY Expression|appos|ligase Expression|dep|correlation correlation|nmod|Kip1 Kip1|amod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21299246	0	Kip1	133,137	p27	91,94	Kip1	p27	1027	10671	Gene	Gene	p27|appos|START_ENTITY disruption|nmod|p27 attributed|nmod|disruption Kip1|acl|attributed Kip1|amod|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21299246	0	Kip1	95,99	p27	129,132	Kip1	p27	1027	10671	Gene	Gene	START_ENTITY|acl|attributed attributed|nmod|disruption disruption|nmod|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21593789	5	Kip1	797,801	p27	793,796	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	We show that in 3D cocultured PKC - null keratinocytes , p27 -LRB- Kip1 -RRB- mRNA was downregulated , whereas JNK/c-Jun signaling was enhanced .
21795702	0	Kip1	102,106	p27	98,101	Kip1	p27	1027	10671	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	WW_domain-containing_E3_ubiquitin_protein_ligase_1 -LRB- WWP1 -RRB- delays cellular senescence by promoting p27 -LRB- Kip1 -RRB- degradation in human diploid fibroblasts .
21813412	0	Kip1	16,20	p27	12,15	Kip1	p27	1027	10671	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of p27 -LRB- Kip1 -RRB- in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian_cancer cells .
21906315	0	Kip1	45,49	p27	41,44	Kip1	p27	1027	3429	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upstream molecular signaling pathways of p27 -LRB- Kip1 -RRB- expression in human breast_cancer cells in vitro : differential effects of 4-hydroxytamoxifen and deficiency of either D - -LRB- + -RRB- - glucose or L-leucine .
22014979	0	Kip1	77,81	p27	73,76	Kip1	p27	1027	3429	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27 -LRB- Kip1 -RRB- phosphorylation .
22580455	0	Kip1	19,23	p27	14,17	Kip1	p27	1027	10671	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of p27 -LRB- Kip1 -RRB- by mitogen-induced tyrosine phosphorylation .
23312942	0	Kip1	44,48	p27	40,43	Kip1	p27	1027	3429	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A single nucleotide polymorphism in the p27 -LRB- Kip1 -RRB- gene is associated with primary patency of lower extremity vein bypass grafts .
23354589	0	Kip1	50,54	p27	46,49	Kip1	p27	1027	10671	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	A novel cyclinE/cyclinA-CDK inhibitor targets p27 -LRB- Kip1 -RRB- degradation , cell cycle progression and cell survival : implications in cancer therapy .
23910095	0	Kip1	51,55	p27	47,50	Kip1	p27	1027	10671	Gene	Gene	Identification|appos|START_ENTITY Identification|nmod|inhibitors inhibitors|nmod|END_ENTITY	Identification of small molecule inhibitors of p27 -LRB- Kip1 -RRB- ubiquitination by high-throughput screening .
24170542	0	Kip1	36,40	p27	32,35	Kip1	p27	1027	10534	Gene	Gene	accumulation|compound|START_ENTITY accumulation|amod|END_ENTITY	Adhesion to fibronectin induces p27 -LRB- Kip1 -RRB- nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance -LRB- CAM-DR -RRB- in RPMI 8,226 cells .
24751519	0	Kip1	29,33	p27	25,28	Kip1	p27	1027	10671	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	IKK-b/NF-kB p65 mediates p27 -LRB- Kip1 -RRB- protein degradation in arsenite response .
25430995	0	Kip1	108,112	p27	104,107	Kip1	p27	1027	10671	Gene	Gene	arrest|appos|START_ENTITY arrest|amod|END_ENTITY	Nardostachys chinensis induces granulocytic differentiation with the suppression of cell growth through p27 -LRB- Kip1 -RRB- protein-related G0/G1 phase arrest in human promyelocytic leukemic cells .
25960164	0	Kip1	166,170	p27	162,165	Kip1	p27	1027	3429	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The activation of type 1 corticotropin_releasing_factor receptor -LRB- CRF-R1 -RRB- inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27 -LRB- Kip1 -RRB- protein up-regulation and c-Myc mRNA down-regulation .
26507530	0	Kip1	70,74	p27	66,69	Kip1	p27	1027	3429	Gene	Gene	Protein|appos|START_ENTITY Protein|appos|END_ENTITY	Discovery of Small Molecules that Inhibit the Disordered Protein , p27 -LRB- Kip1 -RRB- .
26902224	0	Kip1	138,142	p27	134,137	Kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Fad24 , a Positive Regulator of Adipogenesis , Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27 -LRB- Kip1 -RRB- Expression at the Protein Level .
27082696	0	Kip1	35,39	p27	31,34	Kip1	p27	1027	10534	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	The non-canonical functions of p27 -LRB- Kip1 -RRB- in normal and tumor biology .
8630967	0	Kip1	110,114	p27	106,109	Kip1	p27	1027	3429	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Molecular analysis of the cyclin-dependent kinase inhibitor family : p16 -LRB- CDKN2/MTS1/INK4A -RRB- , p18 -LRB- INK4C -RRB- and p27 -LRB- Kip1 -RRB- genes in neuroblastomas .
9054402	0	Kip1	38,42	p27	34,37	Kip1	p27	1027	3429	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Enhanced ribosomal association of p27 -LRB- Kip1 -RRB- mRNA is a mechanism contributing to accumulation during growth_arrest .
9815577	0	Kip1	30,34	p27	26,29	Kip1	p27	1027	3429	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Deregulated expression of p27 -LRB- Kip1 -RRB- in human breast_cancers .
9815624	0	Kip1	50,54	p27	46,49	Kip1	p27	1027	10534	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Loss of the cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- protein in human prostate_cancer correlates with tumor grade .
9927425	0	Kip1	18,22	p27	14,17	Kip1	p27	1027	3429	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Modulation of p27 -LRB- Kip1 -RRB- levels by the cyclin encoded by Kaposi 's _ sarcoma-associated_herpesvirus .
10708569	0	Kip2	32,36	p57	28,31	Kip2	p57	246060(Tax:10116)	246060(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Possible involvement of the p57 -LRB- Kip2 -RRB- gene in bone metabolism .
12176039	0	Kip2	48,52	p57	44,47	Kip2	p57	1028	1028	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	A pro-apoptotic effect of the CDK inhibitor p57 -LRB- Kip2 -RRB- on staurosporine-induced apoptosis in HeLa cells .
12482580	0	Kip2	79,83	p57	75,78	Kip2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of vascular_endothelial_growth_factor in placentas of p57 -LRB- Kip2 -RRB- null embryos .
17112701	0	Kip2	26,30	p57	22,25	Kip2	p57	1028	1028	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	BMP2 and BMP6 control p57 -LRB- Kip2 -RRB- expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes .
17553990	0	Kip2	23,27	p57	19,22	Kip2	p57	1028	1028	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A crucial role for p57 -LRB- Kip2 -RRB- in the intracellular timer that controls oligodendrocyte differentiation .
26165599	0	Kip2	35,39	p57	73,76	Kip2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	p57|dep|START_ENTITY mice|amod|p57 deficiency|nmod|mice occurs|nsubj|deficiency occurs|nmod|manner manner|amod|END_ENTITY	Liver maturation deficiency in p57 -LRB- Kip2 -RRB- - / - mice occurs in a hepatocytic p57 -LRB- Kip2 -RRB- expression-independent manner .
26165599	0	Kip2	77,81	p57	31,34	Kip2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	manner|appos|START_ENTITY occurs|nmod|manner occurs|nsubj|deficiency deficiency|nmod|mice mice|amod|END_ENTITY	Liver maturation deficiency in p57 -LRB- Kip2 -RRB- - / - mice occurs in a hepatocytic p57 -LRB- Kip2 -RRB- expression-independent manner .
26165599	0	Kip2	77,81	p57	73,76	Kip2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	manner|appos|START_ENTITY manner|amod|END_ENTITY	Liver maturation deficiency in p57 -LRB- Kip2 -RRB- - / - mice occurs in a hepatocytic p57 -LRB- Kip2 -RRB- expression-independent manner .
26309408	0	Kip2	18,22	p57	14,17	Kip2	p57	1028	1028	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	High Skp2/Low p57 -LRB- Kip2 -RRB- Expression is Associated with Poor Prognosis in Human Breast_Carcinoma .
27015986	0	Kip2	4,8	p57	0,3	Kip2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	p57 -LRB- Kip2 -RRB- knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann_syndrome .
12482580	0	Kip2	79,83	vascular_endothelial_growth_factor	24,58	Kip2	vascular endothelial growth factor	12577(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of vascular_endothelial_growth_factor in placentas of p57 -LRB- Kip2 -RRB- null embryos .
17404431	0	Kip_1	31,36	p27	27,30	Kip 1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of p27 -LRB- Kip_1 -RRB- expression in renal_cell_carcinoma .
17404436	0	Kip_1	23,28	p27	19,22	Kip 1	p27	1027	3429	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Down-regulation of p27 -LRB- Kip_1 -RRB- cyclin-dependent kinase inhibitor in prostate_cancer : distinct expression in various prostate cells associating with tumor stage and grades .
20066900	0	Kiss-1	0,6	MMP-9	18,23	Kiss-1	MMP-9	3814	4318	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Kiss-1 suppresses MMP-9 expression by activating p38_MAP_kinase in human stomach_cancer .
20066900	0	Kiss-1	0,6	p38_MAP_kinase	49,63	Kiss-1	p38 MAP kinase	3814	1432	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|activating activating|dobj|END_ENTITY	Kiss-1 suppresses MMP-9 expression by activating p38_MAP_kinase in human stomach_cancer .
21458520	0	Kiss1	61,66	DBP	33,36	Kiss1	DBP	289023(Tax:10116)	24309(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Circadian transcriptional factor DBP regulates expression of Kiss1 in the anteroventral periventricular nucleus .
17595229	0	Kiss1	0,5	Gpr54	54,59	Kiss1	Gpr54	280287(Tax:10090)	114229(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|hypogonadism hypogonadism|nmod|END_ENTITY	Kiss1 - / - mice exhibit more variable hypogonadism than Gpr54 - / - mice .
21156837	0	Kiss1	67,72	Gpr54	0,5	Kiss1	Gpr54	280287(Tax:10090)	114229(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY spermatogenesis|nmod|mice show|nmod|spermatogenesis show|nsubj|mice mice|amod|END_ENTITY	Gpr54 - / - mice show more pronounced defects in spermatogenesis than Kiss1 - / - mice and improved spermatogenesis with age when exposed to dietary phytoestrogens .
21852382	0	Kiss1	40,45	Gpr54	55,60	Kiss1	Gpr54	3814	84634	Gene	Gene	receptor|amod|START_ENTITY breast_tumor|nmod|receptor breast_tumor|nsubj|delays delays|amod|END_ENTITY	Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast_tumor initiation , progression , and lung metastasis .
15665093	0	Kisspeptin	0,10	G_protein-coupled_receptor_54	74,103	Kisspeptin	G protein-coupled receptor 54	280287(Tax:10090)	114229(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Kisspeptin directly stimulates gonadotropin-releasing_hormone release via G_protein-coupled_receptor_54 .
25269483	0	Kisspeptin	0,10	PI3K	25,29	Kisspeptin	PI3K	280287(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility .
19477231	0	Kisspeptin	22,32	ghrelin	11,18	Kisspeptin	ghrelin	289023(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat .
15665093	0	Kisspeptin	0,10	gonadotropin-releasing_hormone	31,61	Kisspeptin	gonadotropin-releasing hormone	280287(Tax:10090)	14714(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Kisspeptin directly stimulates gonadotropin-releasing_hormone release via G_protein-coupled_receptor_54 .
18450966	0	Kisspeptin	0,10	gonadotropin-releasing_hormone	25,55	Kisspeptin	gonadotropin-releasing hormone	280287(Tax:10090)	14714(Tax:10090)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|release release|amod|END_ENTITY	Kisspeptin can stimulate gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by a direct action at GnRH nerve terminals .
25269483	0	Kisspeptin	0,10	kisspeptin	63,73	Kisspeptin	kisspeptin	280287(Tax:10090)	280287(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling regulates|dobj|expression expression|compound|END_ENTITY	Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility .
20685868	0	Kisspeptin	0,10	neuropeptide_Y	30,44	Kisspeptin	neuropeptide Y	280287(Tax:10090)	109648(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|amod|END_ENTITY	Kisspeptin directly regulates neuropeptide_Y synthesis and secretion via the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways in NPY-secreting hypothalamic neurons .
21793946	0	Kisspeptin	0,10	prolactin_receptor	54,72	Kisspeptin	prolactin receptor	101107719	443020(Tax:9940)	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	Kisspeptin cells in the ovine arcuate nucleus express prolactin_receptor but not melatonin receptor .
17960174	0	Kit	18,21	BMP-4	0,5	Kit	BMP-4	16590(Tax:10090)	12159(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	BMP-4 upregulates Kit expression in mouse melanoblasts prior to the Kit-dependent cycle of melanogenesis .
19447101	0	Kit	0,3	PI3K	18,22	Kit	PI3K	16590(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation .
11307935	0	Kit	14,17	stem_cell_factor	36,52	Kit	stem cell factor	280832(Tax:9913)	281885(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|receptor receptor|nmod|END_ENTITY	Expression of Kit , the receptor for stem_cell_factor , in bovine peripheral blood .
24999927	0	Kit	21,24	stem_cell_factor	4,20	Kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY regulates|nsubj|signalling END_ENTITY|parataxis|regulates	The stem_cell_factor / Kit signalling pathway regulates mitochondrial function and energy expenditure .
8636116	0	Kit	109,112	stem_cell_factor	6,22	Kit	stem cell factor	3815	4254	Gene	Gene	receptor|appos|START_ENTITY domain|nmod|receptor forms|dobj|domain forms|nsubj|dimer dimer|compound|END_ENTITY	Human stem_cell_factor dimer forms a complex with two molecules of the extracellular domain of its receptor , Kit .
7520776	0	Kit_and_tryptase	41,57	Interleukin-4	0,13	Kit and tryptase	Interleukin-4	3815	3565	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits the expression of Kit_and_tryptase during stem_cell_factor-dependent development of human mast cells from fetal liver cells .
17266790	0	Kit_ligand	4,14	c-Kit_receptor	15,29	Kit ligand	c-Kit receptor	100860807	100861386	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	The Kit_ligand / c-Kit_receptor system in goat ovaries : gene expression and protein localization .
23361909	0	Klf1	48,52	Bcl11a	54,60	Klf1	Bcl11a	16596(Tax:10090)	14025(Tax:10090)	Gene	Gene	START_ENTITY|dobj|mice mice|amod|END_ENTITY	Erythropoiesis and globin switching in compound Klf1 : : Bcl11a mutant mice .
21807894	0	Klf1	0,4	DNase_II-alpha	13,27	Klf1	DNase II-alpha	16596(Tax:10090)	13423(Tax:10090)	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Klf1 affects DNase_II-alpha expression in the central macrophage of a fetal liver erythroblastic island : a non-cell-autonomous role in definitive erythropoiesis .
25075100	0	Klf1	27,31	Dok2	0,4	Klf1	Dok2	16596(Tax:10090)	13449(Tax:10090)	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	Dok2 likely down-regulates Klf1 in mouse erythroleukemia cells .
23065757	0	Klf10	0,5	IL-12p40	15,23	Klf10	IL-12p40	21847(Tax:10090)	16160(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Klf10 inhibits IL-12p40 production in macrophage_colony-stimulating_factor-induced mouse bone marrow-derived macrophages .
26692521	0	Klf17	24,29	Irf6	0,4	Klf17	Irf6	65238(Tax:7955)	393570(Tax:7955)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium , and dominant-negative KLF4 variants are present in patients with cleft_lip_and_palate .
12845703	0	Klf4	46,50	AP-2alpha	86,95	Klf4	AP-2alpha	16600(Tax:10090)	21418(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Dynamic expression of Kr __ ppel-like_factor_4 -LRB- Klf4 -RRB- , a target of transcription factor AP-2alpha during murine mid-embryogenesis .
24084696	0	Klf4	23,27	MicroRNA-137	0,12	Klf4	MicroRNA-137	16600(Tax:10090)	387155(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	MicroRNA-137 represses Klf4 and Tbx3 during differentiation of mouse embryonic stem cells .
16954384	0	Klf4	0,4	Oct3/4	21,27	Klf4	Oct3/4	9314	5460	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells .
19816951	0	Klf4	0,4	Oct4	29,33	Klf4	Oct4	16600(Tax:10090)	100846986	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming .
23139280	0	Klf4	0,4	Slurp1	33,39	Klf4	Slurp1	16600(Tax:10090)	57277(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Klf4 regulates the expression of Slurp1 , which functions as an immunomodulatory peptide in the mouse cornea .
23747203	0	Klf4	0,4	oct4	60,64	Klf4	oct4	9314	5460	Gene	Gene	organizes|nsubj|START_ENTITY organizes|nmod|locus locus|amod|END_ENTITY	Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency .
24066149	0	Klkb1	23,28	Cyp4v3	30,36	Klkb1	Cyp4v3	16621(Tax:10090)	102294(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Regulation of the F11 , Klkb1 , Cyp4v3 gene cluster in livers of metabolically challenged mice .
24066149	0	Klkb1	23,28	F11	18,21	Klkb1	F11	16621(Tax:10090)	109821(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Regulation of the F11 , Klkb1 , Cyp4v3 gene cluster in livers of metabolically challenged mice .
26517365	0	Klotho	0,6	14-3-3	17,23	Klotho	14-3-3	9365	10971	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	Klotho Regulates 14-3-3 Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress .
25377663	0	Klotho	19,25	Akt	93,96	Klotho	Akt	9365	207	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation .
25573451	0	Klotho	31,37	Akt	105,108	Klotho	Akt	83504(Tax:10116)	24185(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY -RSB-|dobj|role -RSB-|nmod|hypoxia/reoxygenation hypoxia/reoxygenation|nmod|downregulation downregulation|nmod|phosphorylation phosphorylation|compound|END_ENTITY	-LSB- Retracted -RSB- Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation .
25855833	1	Klotho	31,37	Akt	105,108	Klotho	Akt	9365	207	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation .
26471128	0	Klotho	15,21	CYP11B2	40,47	Klotho	CYP11B2	16591(Tax:10090)	13072(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Antiaging Gene Klotho Regulates Adrenal CYP11B2 Expression and Aldosterone Synthesis .
25475745	0	Klotho	8,14	Fibroblast_Growth_Factor_23	71,98	Klotho	Fibroblast Growth Factor 23	16591(Tax:10090)	64654(Tax:10090)	Gene	Gene	Protects|nsubj|START_ENTITY Protects|nmod|Independently Independently|nmod|END_ENTITY	Soluble Klotho Protects against Uremic_Cardiomyopathy Independently of Fibroblast_Growth_Factor_23 and Phosphate .
24088960	0	Klotho	99,105	Fibroblast_growth_factor_23	0,27	Klotho	Fibroblast growth factor 23	83504(Tax:10116)	170583(Tax:10116)	Gene	Gene	deficiency|compound|START_ENTITY absence|nmod|deficiency accelerates|nmod|absence accelerates|nsubj|END_ENTITY	Fibroblast_growth_factor_23 accelerates phosphate-induced vascular_calcification in the absence of Klotho deficiency .
25693117	0	Klotho	56,62	Growth_hormone	10,24	Klotho	Growth hormone	9365	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|therapy therapy|compound|END_ENTITY	Effect of Growth_hormone replacement therapy on soluble Klotho in patients with Growth_hormone_deficiency .
18547997	0	Klotho	0,6	PPAR-gamma	27,37	Klotho	PPAR-gamma	9365	5468	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Klotho is a target gene of PPAR-gamma .
18606998	0	Klotho	33,39	TRPV5	73,78	Klotho	TRPV5	9365	56302	Gene	Gene	sialic_acid|nmod|START_ENTITY Removal|nmod|sialic_acid causes|nsubj|Removal causes|dobj|retention retention|nmod|channel channel|nummod|END_ENTITY	Removal of sialic_acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1 .
25378396	0	Klotho	0,6	TRPV5	84,89	Klotho	TRPV5	9365	56302	Gene	Gene	Transient_Receptor_Potential_Vanilloid_5|compound|START_ENTITY Transient_Receptor_Potential_Vanilloid_5|appos|END_ENTITY	Klotho Up-regulates Renal Calcium Channel Transient_Receptor_Potential_Vanilloid_5 -LRB- TRPV5 -RRB- by Intra - and Extracellular N-glycosylation-dependent Mechanisms .
22836100	0	Klotho	14,20	VEGF-A	62,68	Klotho	VEGF-A	9365	7422	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Soluble serum Klotho in diabetic_nephropathy : relationship to VEGF-A .
20966350	0	Klotho	0,6	VEGF_receptor-2	26,41	Klotho	VEGF receptor-2	16591(Tax:10090)	16542(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Klotho is associated with VEGF_receptor-2 and the transient receptor potential canonical-1 Ca2 + channel to maintain endothelial integrity .
24979306	0	Klotho	15,21	endothelin-1	32,44	Klotho	endothelin-1	83504(Tax:10116)	24323(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Antiaging gene Klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats .
19913601	0	Klotho	40,46	epidermal_growth_factor	55,78	Klotho	epidermal growth factor	9365	1950	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the human Klotho gene by epidermal_growth_factor in HEK293 cells ; role of Egr-1 .
25113414	0	Klotho	105,111	fibroblast_growth_factor_23	43,70	Klotho	fibroblast growth factor 23	9365	8074	Gene	Gene	levels|compound|START_ENTITY increasing|dobj|levels accompanied|advcl|increasing END_ENTITY|acl|accompanied	Long-term sevelamer treatment lowers serum fibroblast_growth_factor_23 accompanied with increasing serum Klotho levels in chronic haemodialysis patients .
26069066	0	Klotho	47,53	fibroblast_growth_factor_23	11,38	Klotho	fibroblast growth factor 23	9365	8074	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	The couple fibroblast_growth_factor_23 -LRB- FGF23 -RRB- / Klotho .
22020932	0	Klotho_beta	40,51	FGF19	52,57	Klotho beta	FGF19	152831	9965	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Short hairpin RNA screen indicates that Klotho_beta / FGF19 protein overcomes stasis in human colonic epithelial cells .
22365849	0	Klp10A	0,6	CP110	65,70	Klp10A	CP110	32049(Tax:7227)	33136(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Klp10A , a microtubule-depolymerizing kinesin-13 , cooperates with CP110 to control Drosophila centriole length .
24553290	0	Knittrig	33,41	Rok	55,58	Knittrig	Rok	39004(Tax:7227)	43916(Tax:7227)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response .
25246613	0	Knl1	41,45	Mps1	17,21	Knl1	Mps1	57082	219972	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing .
11677954	0	Kp43	18,22	CD_94	24,29	Kp43	CD 94	3824	3824	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of the Kp43 -LRB- CD_94 -RRB- receptor by natural killer -LRB- NK -RRB- cells in ulcerative_colitis .
26498772	0	Kpnb1	37,42	nuclear_transporter	16,35	Kpnb1	nuclear transporter	3837	84268	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of nuclear_transporter , Kpnb1 , contributes to accelerated cell proliferation - and cell adhesion-mediated drug resistance -LRB- CAM-DR -RRB- in diffuse_large_B-cell_lymphoma .
22331133	0	Kr-pok	0,6	FASN	17,21	Kr-pok	FASN	207259(Tax:10090)	14104(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter .
21698197	0	Kras	20,24	Cten	0,4	Kras	Cten	3845	84951	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas .
25801914	0	Kras	30,34	Dnmt3a	8,14	Kras	Dnmt3a	3845	1788	Gene	Gene	START_ENTITY|nsubj|Loss Loss|nmod|END_ENTITY	Loss of Dnmt3a and endogenous Kras -LRB- G12D / + -RRB- cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis .
24823639	0	Kras	10,14	IL-17	55,60	Kras	IL-17	3845	3605	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic_neoplasia .
20452353	0	Kras	40,44	LKB1	0,4	Kras	LKB1	3845	6794	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	LKB1 haploinsufficiency cooperates with Kras to promote pancreatic_cancer through suppression of p21-dependent growth_arrest .
21451123	0	Kras	56,60	MEK	2,5	Kras	MEK	16653(Tax:10090)	17242(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY disease|nmod|mice abrogates|dobj|disease abrogates|nsubj|inhibitor inhibitor|compound|END_ENTITY	A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice .
21632463	0	Kras	63,67	MEK	43,46	Kras	MEK	16653(Tax:10090)	17242(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras -LRB- G12D -RRB- ; Pten deletion mouse model of ovarian_cancer .
21856775	0	Kras	24,28	MT1-MMP	0,7	Kras	MT1-MMP	16653(Tax:10090)	17387(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	MT1-MMP cooperates with Kras -LRB- G12D -RRB- to promote pancreatic fibrosis through increased TGF-b signaling .
19351816	0	Kras	10,14	PI3K	37,41	Kras	PI3K	16653(Tax:10090)	18708(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo .
26683769	0	Kras	21,25	c-Raf	87,92	Kras	c-Raf	16653(Tax:10090)	110157(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|acl|initiated initiated|nmod|t-CUPM t-CUPM|amod|END_ENTITY	Inhibition of mutant Kras -LRB- G12D -RRB- - initiated murine pancreatic_carcinoma growth by a dual c-Raf and soluble_epoxide_hydrolase inhibitor t-CUPM .
24058630	0	Kras	27,31	p53	52,55	Kras	p53	16653(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial_hyperplasia .
26329623	0	Krebs_von_den_Lungen-6	33,55	KL-6	56,60	Krebs von den Lungen-6	KL-6	4582	4582	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	-LSB- Immunohistochemical Analysis of Krebs_von_den_Lungen-6 -LRB- KL-6 -RRB- Expression in Lung Tissue in Primary Lung_Cancer Patients with High Serum KL-6 Levels -RSB- .
12421700	0	Kremen	0,6	Dickkopf1	30,39	Kremen	Dickkopf1	398249(Tax:8355)	373592(Tax:8355)	Gene	Gene	proteins|compound|START_ENTITY interact|nsubj|proteins interact|nmod|END_ENTITY	Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning .
18068158	0	Kremen1	37,44	Dickkopf-1	9,19	Kremen1	Dickkopf-1	84035(Tax:10090)	13380(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice .
1899909	0	Krev-1	39,45	Rap1A	32,37	Krev-1	Rap1A	109905(Tax:10090)	109905(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The COOH-terminal domain of the Rap1A -LRB- Krev-1 -RRB- protein is isoprenylated and supports transformation by an H-Ras : Rap1A chimeric protein .
25059659	0	Krev_interaction_trapped_1	99,125	sorting_nexin_17	39,55	Krev interaction trapped 1	sorting nexin 17	889	9784	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Structural determinants for binding of sorting_nexin_17 -LRB- SNX17 -RRB- to the cytoplasmic_adaptor protein Krev_interaction_trapped_1 -LRB- KRIT1 -RRB- .
9418958	0	Krox-20	49,56	Egr-1	70,75	Krox-20	Egr-1	13654(Tax:10090)	13653(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Differential regulation of the zinc finger genes Krox-20 and Krox-24 -LRB- Egr-1 -RRB- suggests antagonistic roles in Schwann cells .
8625806	0	Krox-20	73,80	Hoxa-2	24,30	Krox-20	Hoxa-2	13654(Tax:10090)	15399(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20 .
10068633	0	Krox-20	0,7	SCIP	17,21	Krox-20	SCIP	13654(Tax:10090)	18991(Tax:10090)	Gene	Gene	controls|amod|START_ENTITY END_ENTITY|nsubj|controls	Krox-20 controls SCIP expression , cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells .
22511272	0	Krox-20	47,54	p38	33,36	Krox-20	p38	114090(Tax:10116)	81649(Tax:10116)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination .
1793734	0	Krox-24	24,31	P19	91,94	Krox-24	P19	13653(Tax:10090)	83430(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Regulated expression of Krox-24 and other serum-responsive genes during differentiation of P19 embryonal_carcinoma cells .
16864584	0	Krox-24	13,20	cannabinoid_type_1	35,53	Krox-24	cannabinoid type 1	13653(Tax:10090)	12801(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Induction of Krox-24 by endogenous cannabinoid_type_1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway .
20553903	0	Krox20	139,145	FGF3	113,117	Krox20	FGF3	107053633	396267(Tax:9031)	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Analysis of expression and function of FGF-MAPK signaling components in the hindbrain reveals a central role for FGF3 in the regulation of Krox20 , mediated by Pea3 .
8093858	0	Krox20	21,27	HoxB2	38,43	Krox20	HoxB2	13654(Tax:10090)	103889(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The zinc finger gene Krox20 regulates HoxB2 -LRB- Hox2 .8 -RRB- during hindbrain segmentation .
19922439	0	Krox20	14,20	Sox10	40,45	Krox20	Sox10	1959	6663	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells .
26046762	0	Krt19	0,5	Lgr5	9,13	Krt19	Lgr5	3880	8549	Gene	Gene	Cells|amod|START_ENTITY Cells|compound|END_ENTITY	Krt19 -LRB- + -RRB- / Lgr5 -LRB- - -RRB- Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine .
17143583	0	Krt2-6g	63,70	Krt71	56,61	Krt2-6g	Krt71	56735(Tax:10090)	56735(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Morphologic and molecular characterization of two novel Krt71 -LRB- Krt2-6g -RRB- mutations : Krt71rco12 and Krt71rco13 .
17143583	0	Krt71	56,61	Krt2-6g	63,70	Krt71	Krt2-6g	56735(Tax:10090)	56735(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Morphologic and molecular characterization of two novel Krt71 -LRB- Krt2-6g -RRB- mutations : Krt71rco12 and Krt71rco13 .
26226504	0	Kruppel-Like_Factor_4	0,21	Pax6	45,49	Kruppel-Like Factor 4	Pax6	16600(Tax:10090)	18508(Tax:10090)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|compound|END_ENTITY	Kruppel-Like_Factor_4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development .
25230316	0	Kruppel-like_Factor_6	48,69	miR-101	0,7	Kruppel-like Factor 6	miR-101	1316	387143(Tax:10090)	Gene	Gene	Acts|nmod|START_ENTITY Acts|amod|END_ENTITY	miR-101 Acts as a Tumor Suppressor by Targeting Kruppel-like_Factor_6 in Glioblastoma Stem Cells .
15277472	0	Kruppel-like_factor_15	0,22	rhodopsin	79,88	Kruppel-like factor 15	rhodopsin	407241(Tax:9913)	509933(Tax:9913)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Kruppel-like_factor_15 , a zinc-finger transcriptional regulator , represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters .
26212440	0	Kruppel-like_factor_2	0,21	ERK1/2	112,118	Kruppel-like factor 2	ERK1/2	10365	5595;5594	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Kruppel-like_factor_2 inhibit the angiogenesis of cultured human liver sinusoidal endothelial cells through the ERK1/2 signaling pathway .
14565932	0	Kruppel-like_factor_2	65,86	lung_Kruppel-like_factor	39,63	Kruppel-like factor 2	lung Kruppel-like factor	10365	10365	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differential role for IL-7 in inducing lung_Kruppel-like_factor -LRB- Kruppel-like_factor_2 -RRB- expression by naive versus activated T cells .
26471298	0	Kruppel-like_factor_4	61,82	MiR-32	0,6	Kruppel-like factor 4	MiR-32	9314	407036	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MiR-32 promotes gastric_carcinoma tumorigenesis by targeting Kruppel-like_factor_4 .
25037223	0	Kruppel-like_factor_5	185,206	intestinal_alkaline_phosphatase	54,85	Kruppel-like factor 5	intestinal alkaline phosphatase	688	248	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The intestinal epithelial cell differentiation marker intestinal_alkaline_phosphatase -LRB- ALPi -RRB- is selectively induced by histone deacetylase inhibitors -LRB- HDACi -RRB- in colon_cancer cells in a Kruppel-like_factor_5 -LRB- KLF5 -RRB- - dependent manner .
26092983	0	Kruppel-like_factor_5	185,206	intestinal_alkaline_phosphatase	54,85	Kruppel-like factor 5	intestinal alkaline phosphatase	688	248	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The intestinal epithelial cell differentiation marker intestinal_alkaline_phosphatase -LRB- ALPi -RRB- is selectively induced by histone deacetylase inhibitors -LRB- HDACi -RRB- in colon_cancer cells in a Kruppel-like_factor_5 -LRB- KLF5 -RRB- - dependent manner .
15486921	0	Kruppel-like_factor_6	46,67	KLF6	69,73	Kruppel-like factor 6	KLF6	1316	1316	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Frequent inactivation of the tumor suppressor Kruppel-like_factor_6 -LRB- KLF6 -RRB- in hepatocellular_carcinoma .
21109018	0	Kruppel-like_factor_6_and_peroxisome_proliferator-activated_receptor-y	13,83	macrophage_inflammatory_protein-3a	105,139	Kruppel-like factor 6 and peroxisome proliferator-activated receptor-y	macrophage inflammatory protein-3a	58954(Tax:10116)	29538(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The roles of Kruppel-like_factor_6_and_peroxisome_proliferator-activated_receptor-y in the regulation of macrophage_inflammatory_protein-3a at early onset of diabetes .
20463357	0	Kruppel-like_factor_9	16,37	HOXA10	0,6	Kruppel-like factor 9	HOXA10	687	3206	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	HOXA10 inhibits Kruppel-like_factor_9 expression in the human endometrial epithelium .
17717078	0	Kruppel-like_factor_9	0,21	estrogen_receptor_alpha	66,89	Kruppel-like factor 9	estrogen receptor alpha	687	2099	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Kruppel-like_factor_9 is a negative regulator of ligand-dependent estrogen_receptor_alpha signaling in Ishikawa endometrial_adenocarcinoma cells .
24532790	0	Kruppel-like_transcription_factor_4	107,142	S100A14	88,95	Kruppel-like transcription factor 4	S100A14	9314	57402	Gene	Gene	level|nmod|START_ENTITY level|compound|END_ENTITY	12-O-tetradecanoylphorbol-13-acetate promotes breast_cancer cell motility by increasing S100A14 level in a Kruppel-like_transcription_factor_4 -LRB- KLF4 -RRB- - dependent manner .
11779640	0	Kruppel_type_zinc_finger_protein	89,121	ZF5128	73,79	Kruppel type zinc finger protein	ZF5128	57209	25799	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Nucleotide sequence and cell cycle-associated differential expression of ZF5128 , a novel Kruppel_type_zinc_finger_protein gene .
9427625	0	Ksr	7,10	MEK	26,29	Ksr	MEK	16706(Tax:10090)	17242(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Murine Ksr interacts with MEK and inhibits Ras-induced transformation .
9427629	0	Ksr	50,53	MEK	86,89	Ksr	MEK	8844	5609	Gene	Gene	kinase|nmod|START_ENTITY kinase|nmod|interaction interaction|nmod|END_ENTITY	Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK .
8668180	0	Kss1	137,141	Ste7	187,191	Kss1	Ste7	852931(Tax:4932)	851396(Tax:4932)	Gene	Gene	kinases|dobj|START_ENTITY kinases|nmod|END_ENTITY	Signaling in the yeast pheromone response pathway : specific and high-affinity interaction of the mitogen-activated protein -LRB- MAP -RRB- kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7 .
23223795	0	Ku70	31,35	CREB-binding_protein	0,20	Ku70	CREB-binding protein	2547	1387	Gene	Gene	acetylation|amod|START_ENTITY regulates|dobj|acetylation regulates|nsubj|END_ENTITY	CREB-binding_protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma .
20047046	0	Ku70	28,32	Ku80	44,48	Ku70	Ku80	2547	7520	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity .
21075794	0	Ku70	48,52	MSH6	24,28	Ku70	MSH6	2547	2956	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair .
24769731	0	Ku70	8,12	Mcl-1	36,41	Ku70	Mcl-1	2547	4170	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis .
12324457	0	Ku70	14,18	NF-kappa_B	40,50	Ku70	NF-kappa B	2547	4790	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Expression of Ku70 and Ku80 mediated by NF-kappa_B and cyclooxygenase-2 is related to proliferation of human gastric_cancer cells .
17662272	0	Ku70	40,44	Runx3	0,5	Ku70	Runx3	2547	864	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Runx3 interacts with DNA repair protein Ku70 .
10984620	0	Ku70	21,25	TRF2	31,35	Ku70	TRF2	2547	7014	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human Ku70 with TRF2 .
17617666	0	Ku70	76,80	TrkA	29,33	Ku70	TrkA	2547	4914	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|END_ENTITY	Nerve growth factor receptor TrkA signaling in breast_cancer cells involves Ku70 to prevent apoptosis .
11112778	0	Ku70	6,10	heterochromatin_protein_1alpha	26,56	Ku70	heterochromatin protein 1alpha	2547	23468	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human Ku70 interacts with heterochromatin_protein_1alpha .
15824061	0	Ku70/80	6,13	hTR	38,41	Ku70/80	hTR	2547;7520	7012	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human Ku70/80 interacts directly with hTR , the RNA component of human telomerase .
20966962	0	Ku70/86	23,30	Apaf1	41,46	Ku70/86	Apaf1	2547;7520	317	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage .
25797267	0	Ku80	0,4	CBP	21,24	Ku80	CBP	7520	1387	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Ku80 cooperates with CBP to promote COX-2 expression and tumor growth .
16061663	0	Ku80	43,47	H-Ras	10,15	Ku80	H-Ras	22596(Tax:10090)	15461(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Oncogenic H-Ras up-regulates expression of Ku80 to protect cells from gamma-ray irradiation in NIH3T3 cells .
20188166	0	Ku80	94,98	Insulin-like_growth_factor_binding_protein-6	0,44	Ku80	Insulin-like growth factor binding protein-6	7520	3489	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein-6 -LRB- IGFBP-6 -RRB- interacts with DNA-end binding protein Ku80 to regulate cell fate .
20047046	0	Ku80	44,48	Ku70	28,32	Ku80	Ku70	7520	2547	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity .
23851348	0	Ku80	20,24	Nek1	0,4	Ku80	Nek1	7520	4750	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression .
17984099	0	Ku80	0,4	thymosin_beta4	29,43	Ku80	thymosin beta4	7520	7114	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	Ku80 as a novel receptor for thymosin_beta4 that mediates its intracellular activity different from G-actin sequestering .
14672664	0	Ku86	54,58	C-terminal_region	33,50	Ku86	C-terminal region	7520	799	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The 3D solution structure of the C-terminal_region of Ku86 -LRB- Ku86CTR -RRB- .
9244301	0	Kuzbanian	0,9	Notch	45,50	Kuzbanian	Notch	34772(Tax:7227)	31293(Tax:7227)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|processing processing|nmod|END_ENTITY	Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis .
11208532	0	KvLQT1	27,33	IsK	52,55	KvLQT1	IsK	16535(Tax:10090)	16509(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Differential expression of KvLQT1 and its regulator IsK in mouse epithelia .
11414731	0	KvLQT1	23,29	IsK	58,61	KvLQT1	IsK	16535(Tax:10090)	16509(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Mice disrupted for the KvLQT1 potassium channel regulator IsK gene accumulate mature T cells .
10728423	0	KvLQT1	19,25	Isk	79,82	KvLQT1	Isk	3784	3753	Gene	Gene	START_ENTITY|acl:relcl|affect affect|nmod|interactions interactions|nmod|END_ENTITY	Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk .
11747815	0	Kv_channel-interacting_protein_2	16,48	KChIP2	50,56	Kv channel-interacting protein 2	KChIP2	80906(Tax:10090)	80906(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A defect in the Kv_channel-interacting_protein_2 -LRB- KChIP2 -RRB- gene leads to a complete loss of I -LRB- to -RRB- and confers susceptibility to ventricular_tachycardia .
15891643	0	Kvlqt1	36,42	Kcnq1	29,34	Kvlqt1	Kcnq1	16535(Tax:10090)	16535(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Inner_ear_abnormalities in a Kcnq1 -LRB- Kvlqt1 -RRB- knockout mouse : a model of Jervell and Lange-Nielsen_syndrome .
20978132	0	Kzp	0,3	Wnt8	23,27	Kzp	Wnt8	798710(Tax:7955)	30122(Tax:7955)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation .
16134148	0	L-2-hydroxyglutaric_aciduria	43,71	L2HGDH	6,12	L-2-hydroxyglutaric aciduria	L2HGDH	79944	79944	Gene	Gene	mutations|nmod|START_ENTITY mutations|nsubj|END_ENTITY	Novel L2HGDH mutations in 21 patients with L-2-hydroxyglutaric_aciduria of Portuguese origin .
931437	0	L-5	61,64	L-929	54,59	L-5	L-929	654462(Tax:10090)	654462(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Characterization of the synthesized collagen by mouse L-929 -LRB- L-5 -RRB- cells .
931437	0	L-929	54,59	L-5	61,64	L-929	L-5	654462(Tax:10090)	654462(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Characterization of the synthesized collagen by mouse L-929 -LRB- L-5 -RRB- cells .
6617981	0	L-CAT	50,55	lecithin-cholesterol-acyl-transferase	11,48	L-CAT	lecithin-cholesterol-acyl-transferase	3931	3931	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Pattern of lecithin-cholesterol-acyl-transferase -LRB- L-CAT -RRB- activity in the course of liver_cirrhosis .
11171094	0	L-CPT_I	77,84	liver_carnitine_palmitoyltransferase_I	32,70	L-CPT I	liver carnitine palmitoyltransferase I	12894(Tax:10090)	12894(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Long-chain fatty_acids regulate liver_carnitine_palmitoyltransferase_I gene -LRB- L-CPT_I -RRB- expression through a peroxisome-proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- - independent pathway .
18586020	0	L-Dopa_decarboxylase	44,64	DDC	66,69	L-Dopa decarboxylase	DDC	1644	1644	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression analysis and clinical utility of L-Dopa_decarboxylase -LRB- DDC -RRB- in prostate_cancer .
26067610	0	L-FABP	40,46	ACE2	8,12	L-FABP	ACE2	2168	59272	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Urinary ACE2 is associated with urinary L-FABP and albuminuria in patients with chronic_kidney_disease .
21525165	0	L-FABP	57,63	L-type_fatty_acid-binding_protein	22,55	L-FABP	L-type fatty acid-binding protein	14080(Tax:10090)	14080(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Protective effects of L-type_fatty_acid-binding_protein -LRB- L-FABP -RRB- in proximal tubular cells against glomerular_injury in anti-GBM antibody-mediated glomerulonephritis .
19289416	0	L-FABP	0,6	PPARalpha	31,40	L-FABP	PPARalpha	14080(Tax:10090)	19013(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	L-FABP directly interacts with PPARalpha in cultured primary hepatocytes .
12128206	0	L-Maf	0,5	Pax6	30,34	L-Maf	Pax6	395881(Tax:9031)	395943(Tax:9031)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	L-Maf , a downstream target of Pax6 , is essential for chick lens development .
17428264	0	L-Maf	0,5	p27kip1	16,23	L-Maf	p27kip1	395881(Tax:9031)	1027	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	L-Maf regulates p27kip1 expression during chick lens fiber differentiation .
12406576	0	L-SOX5	68,74	long_form_of_Sox5	49,66	L-SOX5	long form of Sox5	6660	6660	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of the human long_form_of_Sox5 -LRB- L-SOX5 -RRB- gene .
25330112	0	L-Selectin	60,70	CD4	98,101	L-Selectin	CD4	6402	920	Gene	Gene	Suppression|appos|START_ENTITY Suppression|nmod|Cells Cells|compound|END_ENTITY	Suppression of Foxo1 Activity and Down-Modulation of CD62L -LRB- L-Selectin -RRB- in HIV-1 Infected Resting CD4 T Cells .
18713968	0	L-Selectin	16,26	FOXO1	0,5	L-Selectin	FOXO1	6402	2308	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase .
25330112	0	L-Selectin	60,70	Foxo1	15,20	L-Selectin	Foxo1	6402	2308	Gene	Gene	Suppression|appos|START_ENTITY Suppression|nmod|Activity Activity|amod|END_ENTITY	Suppression of Foxo1 Activity and Down-Modulation of CD62L -LRB- L-Selectin -RRB- in HIV-1 Infected Resting CD4 T Cells .
26881177	0	L-Selectin	50,60	TNF-a	16,21	L-Selectin	TNF-a	6402	7124	Gene	Gene	Significance|dep|START_ENTITY Significance|nmod|END_ENTITY	Significance of TNF-a and the Adhesion Molecules : L-Selectin and VCAM-1 in Papillary_Thyroid_Carcinoma .
21188077	0	L-Tyrosine_Aminotransferase	50,77	TAT	79,82	L-Tyrosine Aminotransferase	TAT	817022(Tax:3702)	817022(Tax:3702)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Identification and Partial Characterization of an L-Tyrosine_Aminotransferase -LRB- TAT -RRB- from Arabidopsis_thaliana .
10343976	0	L-amino_acid_decarboxylase	28,54	AADC	56,60	L-amino acid decarboxylase	AADC	24311(Tax:10116)	24311(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	L-deprenyl induces aromatic L-amino_acid_decarboxylase -LRB- AADC -RRB- mRNA in the rat substantia nigra and ventral tegmentum .
11148450	0	L-amino_acid_decarboxylase	31,57	AADC	59,63	L-amino acid decarboxylase	AADC	1644	1644	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the aromatic L-amino_acid_decarboxylase -LRB- AADC -RRB- gene and its expression in the attachment and metamorphosis of the barnacle , Balanus amphitrite .
16269145	0	L-amino_acid_decarboxylase	47,73	Vesicular_monoamine_transporter-2	0,33	L-amino acid decarboxylase	Vesicular monoamine transporter-2	24311(Tax:10116)	25549(Tax:10116)	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Vesicular_monoamine_transporter-2 and aromatic L-amino_acid_decarboxylase gene therapy prevents development of motor complications in parkinsonian rats after chronic intermittent L-3 ,4 - dihydroxyphenylalanine administration .
9853519	0	L-amino_acid_decarboxylase	124,150	tyrosine_hydroxylase	90,110	L-amino acid decarboxylase	tyrosine hydroxylase	24311(Tax:10116)	25085(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine_hydroxylase and aromatic L-amino_acid_decarboxylase genes using two separate adeno-associated virus vectors .
22185211	0	L-asparaginase	43,57	AKT	80,83	L-asparaginase	AKT	80150	207	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Curcumin potentiates antitumor activity of L-asparaginase via inhibition of the AKT signaling pathway in acute_lymphoblastic_leukemia .
2080916	0	L-asparaginase	22,36	MB-10	70,75	L-asparaginase	MB-10	66514(Tax:10090)	11536(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Antitumor activity of L-asparaginase from Cylindrocarpon obtusisporum MB-10 and its effect on the immune system .
90334	0	L-asparaginase	42,56	alpha_2-macroglobulin	15,36	L-asparaginase	alpha 2-macroglobulin	80150	2	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of alpha_2-macroglobulin with L-asparaginase .
19422445	0	L-asparaginase	113,127	antithrombin	97,109	L-asparaginase	antithrombin	80150	462	Gene	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Dexamethasone induces a heat-stress response that ameliorates the conformational consequences on antithrombin of L-asparaginase treatment .
20561401	0	L-asparaginase	85,99	asparagine_synthetase	22,43	L-asparaginase	asparagine synthetase	80150	440	Gene	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	-LSB- Relationship between asparagine_synthetase expression level and cell sensitivity to L-asparaginase in human leukemic cell lines -RSB- .
23619474	0	L-ficolin	61,70	ficolin-2	50,59	L-ficolin	ficolin-2	2220	2220	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	The relationship between FCN2 genotypes and serum ficolin-2 -LRB- L-ficolin -RRB- protein concentrations from a large cohort of neonates .
26780456	0	L-glutamate_Decarboxylase_65_Isoform	20,56	GAD65	58,63	L-glutamate Decarboxylase 65 Isoform	GAD65	2572	2572	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of Brain L-glutamate_Decarboxylase_65_Isoform -LRB- GAD65 -RRB- by Phosphorylation at Threonine 95 -LRB- T95 -RRB- .
4857865	2	L-glutamic_acid_60-L-alanine30-L-tyrosine10	90,133	GAT	135,138	L-glutamic acid 60-L-alanine30-L-tyrosine10	GAT	107146(Tax:10090)	107146(Tax:10090)	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Tolerogenic properties of the terpolymer L-glutamic_acid_60-L-alanine30-L-tyrosine10 -LRB- GAT -RRB- for spleen cells from nonresponder -LRB- H-2s and H-2q -RRB- mice .
10467707	0	L-gulono-gamma-lactone_oxidase	4,34	GULO	41,45	L-gulono-gamma-lactone oxidase	GULO	396759(Tax:9823)	396759(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The L-gulono-gamma-lactone_oxidase gene -LRB- GULO -RRB- which is a candidate for vitamin_C deficiency in pigs maps to chromosome 14 .
15021979	0	L-histidine_decarboxylase	26,51	HDC	53,56	L-histidine decarboxylase	HDC	15186(Tax:10090)	15186(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Different patterns of the L-histidine_decarboxylase -LRB- HDC -RRB- gene expression in mice resistant and susceptible to experimental cutaneous_leishmaniasis .
16511063	0	L-lactate_oxidase	59,76	LOX	78,81	L-lactate oxidase	LOX	4015	4015	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Crystallization and preliminary X-ray diffraction study of L-lactate_oxidase -LRB- LOX -RRB- , R181M mutant , from Aerococcus viridans .
12193715	0	L-selectin	95,105	CCR7	125,129	L-selectin	CCR7	20343(Tax:10090)	12775(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
17675559	0	L-selectin	55,65	CD11b	29,34	L-selectin	CD11b	6402	3684	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils .
17765649	0	L-selectin	181,191	CD133	28,33	L-selectin	CD133	6402	8842	Gene	Gene	ligand|amod|START_ENTITY expression|nmod|ligand consumption|nmod|expression stem|nmod|consumption stem|nsubj|Mobilization Mobilization|nmod|+ +|compound|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
7507963	1	L-selectin	146,156	CD16	161,165	L-selectin	CD16	6402	2214	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cleavage of L-selectin via CD16 .
12193715	0	L-selectin	95,105	CD25	25,29	L-selectin	CD25	20343(Tax:10090)	16184(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY expresses|dobj|levels splenocytes|ccomp|expresses splenocytes|nsubj|subpopulation subpopulation|nmod|+ +|compound|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
17182566	0	L-selectin	47,57	CD25	0,4	L-selectin	CD25	20343(Tax:10090)	16184(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY requires|dobj|expression requires|nsubj|migration migration|compound|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
17182566	0	L-selectin	70,80	CD25	0,4	L-selectin	CD25	20343(Tax:10090)	16184(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY balances|nsubj|regulation requires|parataxis|balances requires|nsubj|migration migration|compound|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
10367780	0	L-selectin	0,10	CD34	47,51	L-selectin	CD34	6402	947	Gene	Gene	expression|amod|START_ENTITY enhances|nsubj|expression enhances|dobj|clonogenesis clonogenesis|nmod|progenitors progenitors|compound|END_ENTITY	L-selectin expression enhances clonogenesis of CD34 + cord blood progenitors .
10435581	0	L-selectin	97,107	CD34	128,132	L-selectin	CD34	6402	947	Gene	Gene	ligand|amod|START_ENTITY ligand|acl|displayed displayed|nmod|END_ENTITY	A novel , high endothelial venule-specific sulfotransferase expresses 6-sulfo_sialyl Lewis -LRB- x -RRB- , an L-selectin ligand displayed by CD34 .
10681720	0	L-selectin	0,10	CD34	32,36	L-selectin	CD34	6402	947	Gene	Gene	expression|amod|START_ENTITY expression|nsubj|expression expression|advmod|low low|nmod|cells cells|nummod|+ +|compound|END_ENTITY	L-selectin expression is low on CD34 + cells from patients with chronic_myeloid_leukemia and interferon-a up-regulates this expression .
11164112	0	L-selectin	12,22	CD34	43,47	L-selectin	CD34	6402	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Decrease of L-selectin expression on human CD34 + cells on freeze-thawing and rapid recovery with short-term incubation .
11895802	0	L-selectin	69,79	CD34	36,40	L-selectin	CD34	6402	947	Gene	Gene	recognition|amod|START_ENTITY participating|nmod|recognition putatively|xcomp|participating putatively|nsubj|O-glycans O-glycans|nmod|END_ENTITY	O-glycans on human high endothelial CD34 putatively participating in L-selectin recognition .
12063026	0	L-selectin	83,93	CD34	35,39	L-selectin	CD34	6402	947	Gene	Gene	role|nmod|START_ENTITY outgrowth|dep|role outgrowth|nmod|cells cells|amod|END_ENTITY	Homing and clonogenic outgrowth of CD34 -LRB- + -RRB- peripheral blood stem cells : a role for L-selectin ?
12889478	0	L-selectin	57,67	CD34	28,32	L-selectin	CD34	6402	947	Gene	Gene	ligand|nsubj|START_ENTITY functions|advcl|ligand functions|nsubj|Endoglycan Endoglycan|appos|member member|nmod|family family|compound|END_ENTITY	Endoglycan , a member of the CD34 family , functions as an L-selectin ligand through modification with tyrosine sulfation and sialyl Lewis x .
17765649	0	L-selectin	181,191	CD34	22,26	L-selectin	CD34	6402	947	Gene	Gene	ligand|amod|START_ENTITY expression|nmod|ligand consumption|nmod|expression stem|nmod|consumption stem|nsubj|Mobilization Mobilization|nmod|+ +|compound|END_ENTITY	Mobilization of human CD34 + CD133 + and CD34 + CD133 -LRB- - -RRB- stem cells in vivo by consumption of an extract from Aphanizomenon flos-aquae -- related to modulation of CXCR4 expression by an L-selectin ligand ?
19359410	0	L-selectin	47,57	CD34	32,36	L-selectin	CD34	6402	947	Gene	Gene	carry|nsubj|START_ENTITY END_ENTITY|ccomp|carry	Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O - and N-glycans .
7522633	0	L-selectin	84,94	CD34	37,41	L-selectin	CD34	20343(Tax:10090)	12490(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|expression expression|nmod|END_ENTITY	Global vascular expression of murine CD34 , a sialomucin-like endothelial ligand for L-selectin .
7538823	0	L-selectin	55,65	CD34	36,40	L-selectin	CD34	6402	947	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|molecules molecules|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Expression of adhesion molecules on CD34 + cells : CD34 + L-selectin + cells predict a rapid platelet recovery after peripheral blood stem cell transplantation .
7692600	0	L-selectin	11,21	CD34	49,53	L-selectin	CD34	6402	947	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of L-selectin to the vascular sialomucin CD34 .
8542944	0	L-selectin	27,37	CD34	59,63	L-selectin	CD34	6402	947	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of L-selectin , VLA-4 , and LFA-1 on CD34 + progenitor cells from bone_marrow and peripheral blood during G-CSF-enhanced recovery .
9134437	0	L-selectin	95,105	CD34	58,62	L-selectin	CD34	6402	947	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|requirements requirements|nmod|glycoform glycoform|nmod|END_ENTITY	Sulfation and sialylation requirements for a glycoform of CD34 , a major endothelial ligand for L-selectin in porcine peripheral lymph nodes .
9517512	0	L-selectin	0,10	CD34	25,29	L-selectin	CD34	6402	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	L-selectin expression in CD34 positive cells in chronic myeloid_leukemia .
9625756	0	L-selectin	83,93	CD34	108,112	L-selectin	CD34	6402	947	Gene	Gene	ligand|nmod|START_ENTITY venule|acl|ligand podocalyxin-like_protein|nmod|venule Identification|nmod|podocalyxin-like_protein Identification|dep|parallels parallels|nmod|END_ENTITY	Identification of podocalyxin-like_protein as a high endothelial venule ligand for L-selectin : parallels to CD34 .
10967018	0	L-selectin	77,87	CD4	58,61	L-selectin	CD4	6402	920	Gene	Gene	CD45RO|appos|START_ENTITY END_ENTITY|appos|CD45RO	Adenoids provide a microenvironment for the generation of CD4 -LRB- + -RRB- , CD45RO -LRB- + -RRB- , L-selectin -LRB- - -RRB- , CXCR4 -LRB- + -RRB- , CCR5 -LRB- + -RRB- T lymphocytes , a lymphocyte phenotype found in the middle_ear_effusion .
11859099	0	L-selectin	65,75	CD4	98,101	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligands|amod|START_ENTITY show|nsubj|ligands show|dobj|+ +|compound|END_ENTITY	Fucosyltransferase_VII-deficient mice with defective E - , P - , and L-selectin ligands show impaired CD4 + and CD8 + T cell migration into the skin , but normal extravasation into visceral organs .
11882033	0	L-selectin	57,67	CD4	71,74	L-selectin	CD4	6402	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential expression of beta1 and beta2 integrins and L-selectin on CD4 + and CD8 + T lymphocytes in human blood : comparative analysis between isolated cells , whole blood samples and cryopreserved preparations .
12193715	0	L-selectin	95,105	CD4	21,24	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY expresses|dobj|levels splenocytes|ccomp|expresses splenocytes|nsubj|subpopulation subpopulation|nmod|+ +|compound|END_ENTITY	The subpopulation of CD4 + CD25 + splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7 .
12355444	0	L-selectin	39,49	CD4	77,80	L-selectin	CD4	6402	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Inhibition of TCR-mediated shedding of L-selectin -LRB- CD62L -RRB- on human and mouse CD4 + T cells by metalloproteinase inhibition : analysis of the regulation of Th1/Th2 function .
12496379	0	L-selectin	14,24	CD4	79,82	L-selectin	CD4	6402	920	Gene	Gene	expression|amod|START_ENTITY edge|dep|expression Cutting|dobj|edge Cutting|nsubj|cells cells|nummod|END_ENTITY	Cutting edge : L-selectin -LRB- CD62L -RRB- expression distinguishes small resting memory CD4 + T cells that preferentially respond to recall antigen .
15292057	0	L-selectin	27,37	CD4	42,45	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	L-Selectin|nmod|START_ENTITY L-Selectin|acl|END_ENTITY	L-Selectin -LRB- hi -RRB- but not the L-selectin -LRB- lo -RRB- CD4 +25 + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection .
15699171	0	L-selectin	0,10	CD4	72,75	L-selectin	CD4	6402	920	Gene	Gene	beta|amod|START_ENTITY participate|nsubj|beta participate|nmod|recruitment recruitment|compound|END_ENTITY	L-selectin , alpha 4 beta 1 , and alpha 4 beta 7 integrins participate in CD4 + T cell recruitment to chronically inflamed small intestine .
16105972	0	L-selectin	0,10	CD4	39,42	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	integrin|amod|START_ENTITY integrin|nmod|cells cells|compound|END_ENTITY	L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute_colitis of graft-versus-host_disease .
17182566	0	L-selectin	47,57	CD4	5,8	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY requires|dobj|expression requires|nsubj|migration migration|compound|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
17182566	0	L-selectin	70,80	CD4	5,8	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY balances|nsubj|regulation requires|parataxis|balances requires|nsubj|migration migration|compound|END_ENTITY	CD25 + CD4 + regulatory T cell migration requires L-selectin expression : L-selectin transcriptional regulation balances constitutive receptor turnover .
19419934	0	L-selectin	24,34	CD4	65,68	L-selectin	CD8	6402	925	Gene	Gene	+|compound|START_ENTITY percentage|nmod|+ +|nsubj|percentage +|dep|blood blood|dep|+ +|compound|END_ENTITY	Increased percentage of L-selectin + and ICAM-1 + peripheral blood CD4 + / CD8 + T cells in active Graves ' _ ophthalmopathy .
19553533	0	L-selectin	47,57	CD4	72,75	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY down-regulate|dobj|expression down-regulate|nmod|+ +|compound|END_ENTITY	Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4 + and CD8 + T cells .
7525854	0	L-selectin	64,74	CD4	15,18	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|Entry Entry|nmod|cells cells|compound|END_ENTITY	Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin .
8698378	0	L-selectin	14,24	CD4	91,94	L-selectin	CD4	6402	920	Gene	Gene	Expression|nmod|START_ENTITY discriminates|nsubj|Expression discriminates|dobj|cells cells|compound|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
8921958	0	L-selectin	33,43	CD4	0,3	L-selectin	CD4	29259(Tax:10116)	24932(Tax:10116)	Gene	Gene	protect|nsubj|START_ENTITY express|ccomp|protect thymocytes|acl:relcl|express CD8|dep|thymocytes CD8|compound|END_ENTITY	CD4 + CD8 - thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer .
9111498	0	L-selectin	97,107	CD4	65,68	L-selectin	CD4	6402	920	Gene	Gene	expression|amod|START_ENTITY cells|nmod|expression cells|compound|END_ENTITY	Severe allergic_reactions to foods are predicted by increases of CD4 + CD45RO + T cells and loss of L-selectin expression .
9174603	0	L-selectin	0,10	CD4	38,41	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|trafficking trafficking|amod|naive naive|dep|END_ENTITY	L-selectin is not essential for naive CD4 cell trafficking or development of primary responses in Peyer 's patches .
9531305	0	L-selectin	16,26	CD4	79,82	L-selectin	CD4	6402	920	Gene	Gene	cells|amod|START_ENTITY Purification|nmod|cells promotes|nsubj|Purification promotes|dobj|generation generation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Purification of L-selectin -LRB- low -RRB- cells promotes the generation of highly potent CD4 antitumor effector T lymphocytes .
9725264	0	L-selectin	60,70	CD4	33,36	L-selectin	CD4	20343(Tax:10090)	12504(Tax:10090)	Gene	Gene	tolerance|amod|START_ENTITY expressing|dobj|tolerance thymocytes|xcomp|expressing thymocytes|nsubj|+ +|compound|END_ENTITY	Mature mainstream TCR_alpha beta + CD4 + thymocytes expressing L-selectin mediate `` active tolerance '' in the nonobese diabetic mouse .
9893333	0	L-selectin	15,25	CD4	47,50	L-selectin	CD4	6402	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	-LSB- Expression of L-selectin on peripheral memory CD4 + T cells in atopic_diseases -RSB- .
11095749	0	L-selectin	35,45	CD44	24,28	L-selectin	CD44	6402	960	Gene	Gene	ligand|amod|START_ENTITY ligand|nsubj|glycoform glycoform|nmod|END_ENTITY	A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells .
8757865	0	L-selectin	129,139	CD44	141,145	L-selectin	CD44	20343(Tax:10090)	12505(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Increased susceptibility to primary_infection with Listeria_monocytogenes in germfree mice may be due to lack of accumulation of L-selectin + CD44 + T cells in sites of inflammation .
10622231	0	L-selectin	68,78	CD62L	80,85	L-selectin	CD62L	6402	6402	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inverse association between endogenous glucocorticoid secretion and L-selectin -LRB- CD62L -RRB- expression in trauma patients .
10733478	0	L-selectin	38,48	CD62L	50,55	L-selectin	CD62L	6402	6402	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Circulating concentrations of soluble L-selectin -LRB- CD62L -RRB- in patients with primary Sj __ gren 's _ syndrome .
12496379	0	L-selectin	14,24	CD62L	26,31	L-selectin	CD62L	6402	6402	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cutting edge : L-selectin -LRB- CD62L -RRB- expression distinguishes small resting memory CD4 + T cells that preferentially respond to recall antigen .
12580810	0	L-selectin	55,65	CD62L	67,72	L-selectin	CD62L	6402	6402	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Decreased intercellular_adhesion_molecule-1 -LRB- CD54 -RRB- and L-selectin -LRB- CD62L -RRB- expression on peripheral blood natural killer cells in asthmatic children with acute exacerbation .
14667200	0	L-selectin	4,14	CD62L	16,21	L-selectin	CD62L	6402	6402	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Low L-selectin -LRB- CD62L -RRB- expression in acute_myeloid_leukemia correlates with a bad cytogenetic risk .
15776384	0	L-selectin	10,20	CD62L	22,27	L-selectin	CD62L	6402	6402	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of L-selectin -LRB- CD62L -RRB- on human leukocytes in disseminated_cryptococcosis_with_and_without_associated_HIV-1_infection .
16788684	0	L-selectin	141,151	CD62L	153,158	L-selectin	CD62L	6402	6402	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Apoptotic lymphocytes and CD34 + cells in cryopreserved cord blood detected by the fluorescent vital dye SYTO 16 and correlation with loss of L-selectin -LRB- CD62L -RRB- expression .
19240088	0	L-selectin	23,33	CD62L	35,40	L-selectin	CD62L	6402	6402	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cyclical expression of L-selectin -LRB- CD62L -RRB- by recirculating T cells .
7543141	0	L-selectin	64,74	CD62L	76,81	L-selectin	CD62L	6402	6402	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Structural requirements regulate endoproteolytic release of the L-selectin -LRB- CD62L -RRB- adhesion receptor from the cell surface of leukocytes .
7591847	0	L-selectin	24,34	CD62L	36,41	L-selectin	CD62L	6402	6402	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Spatial distribution of L-selectin -LRB- CD62L -RRB- on human lymphocytes and transfected murine L1-2 cells .
8698378	0	L-selectin	14,24	CD62L	26,31	L-selectin	CD62L	6402	6402	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
9038755	0	L-selectin	37,47	CD62L	49,54	L-selectin	CD62L	6402	6402	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differential regulation of leucocyte L-selectin -LRB- CD62L -RRB- expression in normal lymphoid and inflamed extralymphoid tissues .
9422729	0	L-selectin	33,43	CD62L	45,50	L-selectin	CD62L	6402	6402	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Affinity and kinetic analysis of L-selectin -LRB- CD62L -RRB- binding to glycosylation-dependent cell-adhesion molecule-1 .
11472411	0	L-selectin	15,25	CD8	72,75	L-selectin	CD8	6402	925	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Elevated serum L-selectin levels and decreased L-selectin expression on CD8 -LRB- + -RRB- lymphocytes in systemic_sclerosis .
22719212	0	L-selectin	83,93	CD8	106,109	L-selectin	CD8	6402	925	Gene	Gene	subset|amod|START_ENTITY subset|compound|END_ENTITY	Treatment with transcatheter arterial chemoembolization induces an increase of the L-selectin -LRB- low -RRB- CXCR3 + CD8 + T cell subset in patients with hepatocellular_carcinoma .
18619508	0	L-selectin	0,10	CSF-1	28,33	L-selectin	CSF-1	6402	1435	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	L-selectin ligation-induced CSF-1 gene transcription is regulated by AP-1 in a c-Abl kinase-dependent manner .
22719212	0	L-selectin	83,93	CXCR3	99,104	L-selectin	CXCR3	6402	2833	Gene	Gene	subset|amod|START_ENTITY subset|compound|END_ENTITY	Treatment with transcatheter arterial chemoembolization induces an increase of the L-selectin -LRB- low -RRB- CXCR3 + CD8 + T cell subset in patients with hepatocellular_carcinoma .
12165498	0	L-selectin	0,10	E-selectin	24,34	L-selectin	E-selectin	6402	6401	Gene	Gene	serves|nsubj|START_ENTITY serves|nmod|ligand ligand|amod|END_ENTITY	L-selectin serves as an E-selectin ligand on cultured human T lymphoblasts .
12612222	0	L-selectin	28,38	E-selectin	8,18	L-selectin	E-selectin	6402	6401	Gene	Gene	ICAM-1|amod|START_ENTITY END_ENTITY|appos|ICAM-1	Soluble E-selectin , soluble L-selectin and soluble ICAM-1 in bronchopulmonary_dysplasia , and changes with dexamethasone .
1374233	0	L-selectin	14,24	E-selectin	90,100	L-selectin	E-selectin	6402	6401	Gene	Gene	Comparison|nmod|START_ENTITY ligand|nsubj|Comparison ligand|parataxis|bind bind|xcomp|Le Le|nsubj|ligands ligands|amod|END_ENTITY	Comparison of L-selectin and E-selectin ligand specificities : the L-selectin can bind the E-selectin ligands sialyl Le -LRB- x -RRB- and sialyl Le -LRB- a -RRB- .
1374233	0	L-selectin	66,76	E-selectin	90,100	L-selectin	E-selectin	6402	6401	Gene	Gene	bind|nsubj|START_ENTITY bind|xcomp|Le Le|nsubj|ligands ligands|amod|END_ENTITY	Comparison of L-selectin and E-selectin ligand specificities : the L-selectin can bind the E-selectin ligands sialyl Le -LRB- x -RRB- and sialyl Le -LRB- a -RRB- .
15187162	0	L-selectin	27,37	E-selectin	78,88	L-selectin	E-selectin	6402	6401	Gene	Gene	capping|nmod|START_ENTITY capping|nmod|END_ENTITY	Shear-dependent capping of L-selectin and P-selectin_glycoprotein_ligand_1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils .
20564190	0	L-selectin	20,30	E-selectin	74,84	L-selectin	E-selectin	6402	6401	Gene	Gene	neutrophil|amod|START_ENTITY neutrophil|acl|rolling rolling|nmod|END_ENTITY	PI3K is involved in L-selectin - and PSGL-1-mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly .
23451187	0	L-selectin	108,118	E-selectin	65,75	L-selectin	E-selectin	6402	6401	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	P-selectin_glycoprotein_ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces .
8902148	0	L-selectin	8,18	E-selectin	77,87	L-selectin	E-selectin	6402	6401	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Soluble L-selectin in peripheral_arterial_disease : relationship with soluble E-selectin and soluble P-selectin .
8977216	0	L-selectin	23,33	E-selectin	42,52	L-selectin	E-selectin	6402	6401	Gene	Gene	kinetics|nmod|START_ENTITY kinetics|acl|rolling rolling|advmod|than than|nmod|END_ENTITY	The faster kinetics of L-selectin than of E-selectin and P-selectin rolling at comparable binding strength .
9024699	0	L-selectin	0,10	E-selectin	72,82	L-selectin	E-selectin	6402	20339(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	L-selectin from human , but not from mouse neutrophils binds directly to E-selectin .
9133922	0	L-selectin	90,100	E-selectin	78,88	L-selectin	E-selectin	6402	6401	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
23133314	0	L-selectin	25,35	FOXO1	0,5	L-selectin	FOXO1	6402	2308	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FOXO1 Up-Regulates Human L-selectin Expression Through Binding to a Consensus FOXO1 Motif .
23133314	0	L-selectin	25,35	FOXO1	78,83	L-selectin	FOXO1	6402	2308	Gene	Gene	Expression|compound|START_ENTITY Expression|dep|Binding Binding|nmod|Motif Motif|compound|END_ENTITY	FOXO1 Up-Regulates Human L-selectin Expression Through Binding to a Consensus FOXO1 Motif .
19136962	0	L-selectin	63,73	Foxo1	0,5	L-selectin	Foxo1	6402	2308	Gene	Gene	receptor|compound|START_ENTITY regulating|dobj|receptor links|advcl|regulating links|nsubj|END_ENTITY	Foxo1 links homing and survival of naive T cells by regulating L-selectin , CCR7 and interleukin 7 receptor .
22814108	0	L-selectin	63,73	GSK3	37,41	L-selectin	GSK3	20343(Tax:10090)	56637(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	AKT/SGK-sensitive phosphorylation of GSK3 in the regulation of L-selectin and perforin expression as well as activation induced cell death of T-lymphocytes .
9236448	0	L-selectin	48,58	Glucocorticoid_receptor	0,23	L-selectin	Glucocorticoid receptor	6402	2908	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glucocorticoid_receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils .
7538131	0	L-selectin	74,84	GlyCAM-1	30,38	L-selectin	GlyCAM-1	6402	644076	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Structure of the O-glycans in GlyCAM-1 , an endothelial-derived ligand for L-selectin .
8879206	0	L-selectin	35,45	GlyCAM-1	0,8	L-selectin	GlyCAM-1	6402	644076	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	GlyCAM-1 , a physiologic ligand for L-selectin , activates beta_2 integrins on naive peripheral lymphocytes .
22977256	0	L-selectin	91,101	Glycodelin-A	0,12	L-selectin	Glycodelin-A	6402	5047	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Glycodelin-A stimulates interleukin-6 secretion by human monocytes and macrophages through L-selectin and the extracellular signal-regulated kinase pathway .
8933279	0	L-selectin	51,61	ICAM-1	27,33	L-selectin	ICAM-1	20343(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune_insulitis of NOD mice and association with both Th1 - and Th2-type infiltrates .
9133922	0	L-selectin	90,100	ICAM-1	54,60	L-selectin	ICAM-1	6402	3383	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|compound|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
9133922	0	L-selectin	90,100	ICAM-3	62,68	L-selectin	ICAM-3	6402	3385	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	A distinct profile of six soluble adhesion molecules -LRB- ICAM-1 , ICAM-3 , VCAM-1 , E-selectin , L-selectin and P-selectin -RRB- in rheumatoid_arthritis .
10528206	0	L-selectin	43,53	IL-8	25,29	L-selectin	IL-8	6402	3576	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Neutrophil dysfunctions , IL-8 , and soluble L-selectin plasma levels in rapidly progressive versus adult and localized juvenile_periodontitis : variations according to disease severity and microbial flora .
9415029	0	L-selectin	0,10	JNK	21,24	L-selectin	JNK	6402	5599	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	L-selectin activates JNK via src-like tyrosine kinases and the small G-protein Rac .
9529172	0	L-selectin	40,50	L-selectin	82,92	L-selectin	L-selectin	6402	6402	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b .
9529172	0	L-selectin	82,92	L-selectin	40,50	L-selectin	L-selectin	6402	6402	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b .
7690324	0	L-selectin	33,43	LECAM-1	24,31	L-selectin	LECAM-1	29259(Tax:10116)	29259(Tax:10116)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of rat LECAM-1 -LRB- L-selectin -RRB- by the use of monoclonal antibodies and evidence for the presence of soluble LECAM-1 in rat sera .
18653462	0	L-selectin	24,34	Lck	17,20	L-selectin	Lck	20343(Tax:10090)	16818(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Critical role of Lck in L-selectin signaling induced by sulfatides engagement .
8839831	0	L-selectin	58,68	P-selectin_glycoprotein_ligand-1	0,32	L-selectin	P-selectin glycoprotein ligand-1	6402	6404	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- is a ligand for L-selectin in neutrophil aggregation .
15579466	0	L-selectin	39,49	PSGL-1	14,20	L-selectin	PSGL-1	6402	6404	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Regulation of PSGL-1 interactions with L-selectin , P-selectin , and E-selectin : role of human fucosyltransferase-IV_and _ - VII .
9725264	0	L-selectin	60,70	TCR_alpha	18,27	L-selectin	TCR alpha	20343(Tax:10090)	21473(Tax:10090)	Gene	Gene	tolerance|amod|START_ENTITY expressing|dobj|tolerance thymocytes|xcomp|expressing thymocytes|nsubj|+ +|compound|END_ENTITY	Mature mainstream TCR_alpha beta + CD4 + thymocytes expressing L-selectin mediate `` active tolerance '' in the nonobese diabetic mouse .
15859550	0	L-selectin	15,25	TNF-alpha	70,79	L-selectin	TNF-alpha	6402	7124	Gene	Gene	Expression|nmod|START_ENTITY stimulated|nsubj|Expression stimulated|nmod|END_ENTITY	-LSB- Expression of L-selectin on the surface of neutrophils stimulated by TNF-alpha and level of sL-selectin in serum of patients with lung_cancer -RSB- .
10221651	1	L-selectin	148,158	Versican	80,88	L-selectin	Versican	6402	1462	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	I. Versican , a large chondroitin sulfate proteoglycan , is a ligand for L-selectin .
11342653	0	L-selectin	83,93	annexin_1	21,30	L-selectin	annexin 1	6402	301	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	A potential role for annexin_1 as a physiologic mediator of glucocorticoid-induced L-selectin shedding from myeloid cells .
12181114	0	L-selectin	31,41	interleukin-6	14,27	L-selectin	interleukin-6	6402	3569	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	The effect of interleukin-6 on L-selectin levels on polymorphonuclear_leukocytes .
8583820	0	L-selectin	124,134	interleukin-8	161,174	L-selectin	interleukin-8	6402	3576	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Effects of inhibition of complement activation using recombinant soluble complement receptor 1 on neutrophil CD11b/CD18 and L-selectin expression and release of interleukin-8 and elastase in simulated cardiopulmonary bypass .
7678616	1	L-selectin	116,126	lymph_node_homing_receptor	89,115	L-selectin	lymph node homing receptor	6402	6402	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	I. Differential regulation of the peripheral lymph_node_homing_receptor L-selectin on T cells during the virgin to memory cell transition .
11129654	0	L-selectin	47,57	neutral_sphingomyelinase	101,125	L-selectin	neutral sphingomyelinase	6402	6610	Gene	Gene	shed|dobj|START_ENTITY shed|nmod|generation generation|nmod|END_ENTITY	Streptolysin_O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral_sphingomyelinase .
9716456	0	L-selectin	0,10	neutral_sphingomyelinase	26,50	L-selectin	neutral sphingomyelinase	6402	6610	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	L-selectin stimulates the neutral_sphingomyelinase and induces release of ceramide .
26279759	0	L-type_amino_acid_transporter_1	27,58	LAT1	60,64	L-type amino acid transporter 1	LAT1	8140	8140	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of L-type_amino_acid_transporter_1 -LRB- LAT1 -RRB- expression in patients with ovarian_tumors .
26279759	0	L-type_amino_acid_transporter_1	27,58	LAT1	60,64	L-type amino acid transporter 1	LAT1	8140	8140	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of L-type_amino_acid_transporter_1 -LRB- LAT1 -RRB- expression in patients with ovarian_tumors .
21525165	0	L-type_fatty_acid-binding_protein	22,55	L-FABP	57,63	L-type fatty acid-binding protein	L-FABP	14080(Tax:10090)	14080(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Protective effects of L-type_fatty_acid-binding_protein -LRB- L-FABP -RRB- in proximal tubular cells against glomerular_injury in anti-GBM antibody-mediated glomerulonephritis .
14612427	0	L11	18,21	MDM2	55,59	L11	MDM2	6135	4193	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway .
23776465	0	L11	43,46	Myeloma_overexpressed_2	0,23	L11	Myeloma overexpressed 2	6135	150678	Gene	Gene	localization|nummod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Myeloma_overexpressed_2 -LRB- Myeov2 -RRB- regulates L11 subnuclear localization through Nedd8 modification .
25829192	0	L11	18,21	erythropoietin	91,105	L11	erythropoietin	6135	2056	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Ribosomal protein L11 and retinol_dehydrogenase_11 induced erythroid_proliferation without erythropoietin in UT-7 / Epo erythroleukemic cells .
6773542	1	L12	148,151	L13	153,156	L12	L13	46003	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	L16	158,161	L12	L16	46003	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	L18	163,166	L12	L18	46003	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	L19	168,171	L12	L19	46003	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	S13	73,76	L12	S13	46003	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	S14	78,81	L12	S14	46003	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	S16	83,86	L12	S16	46003	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	S19	88,91	L12	S19	46003	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L12	148,151	S24	111,114	L12	S24	46003	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
3883346	0	L12	36,39	ribosomal_protein_L7	15,35	L12	ribosomal protein L7	6136	6129	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of ribosomal_protein_L7 / L12 in control of translational accuracy .
6773542	1	L13	153,156	L12	148,151	L13	L12	249394	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	L16	158,161	L13	L16	249394	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	L18	163,166	L13	L18	249394	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	L19	168,171	L13	L19	249394	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	S13	73,76	L13	S13	249394	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	S14	78,81	L13	S14	249394	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	S16	83,86	L13	S16	249394	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	S19	88,91	L13	S19	249394	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L13	153,156	S24	111,114	L13	S24	249394	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	L12	148,151	L16	L12	5657033	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	L13	153,156	L16	L13	5657033	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	L18	163,166	L16	L18	5657033	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	L19	168,171	L16	L19	5657033	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	S13	73,76	L16	S13	5657033	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	S14	78,81	L16	S14	5657033	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	S16	83,86	L16	S16	5657033	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	S19	88,91	L16	S19	5657033	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L16	158,161	S24	111,114	L16	S24	5657033	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	L12	148,151	L18	L12	251730	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	L13	153,156	L18	L13	251730	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	L16	158,161	L18	L16	251730	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	L19	168,171	L18	L19	251730	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	S13	73,76	L18	S13	251730	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	S14	78,81	L18	S14	251730	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	S16	83,86	L18	S16	251730	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	S19	88,91	L18	S19	251730	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L18	163,166	S24	111,114	L18	S24	251730	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	L12	148,151	L19	L12	247160	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	L13	153,156	L19	L13	247160	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	L16	158,161	L19	L16	247160	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	L18	163,166	L19	L18	247160	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	S13	73,76	L19	S13	247160	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	S14	78,81	L19	S14	247160	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	S16	83,86	L19	S16	247160	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	S19	88,91	L19	S19	247160	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	L19	168,171	S24	111,114	L19	S24	247160	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
21360711	0	L1CAM	27,32	L1_Cell_adhesion_molecule	0,25	L1CAM	L1 Cell adhesion molecule	3897	3897	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	L1_Cell_adhesion_molecule -LRB- L1CAM -RRB- expression at the cancer invasive front is a novel prognostic marker of pancreatic_ductal_adenocarcinoma .
27028855	0	L1CAM	85,90	L1_cell_adhesion_molecule	58,83	L1CAM	L1 cell adhesion molecule	3897	3897	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value and clinicopathologic characteristics of L1_cell_adhesion_molecule -LRB- L1CAM -RRB- in a large series of vulvar_squamous_cell_carcinomas .
9521424	0	L1CAM	144,149	L1_cell_adhesion_molecule	117,142	L1CAM	L1 cell adhesion molecule	3897	3897	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple exon screening using restriction endonuclease fingerprinting -LRB- REF -RRB- : detection of six novel mutations in the L1_cell_adhesion_molecule -LRB- L1CAM -RRB- gene .
21297581	0	L1CAM	0,5	NBS1	82,86	L1CAM	NBS1	3897	4683	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1 .
21109948	0	L1CAM	126,131	Slug	36,40	L1CAM	Slug	3897	6591	Gene	Gene	expression|compound|START_ENTITY transforming_growth_factor-b1|dep|expression essential|nmod|transforming_growth_factor-b1 essential|nsubj|Binding Binding|acl|END_ENTITY	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
21109948	0	L1CAM	48,53	Slug	36,40	L1CAM	Slug	3897	6591	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
25149066	0	L1CAM	37,42	miR-21-3p	0,9	L1CAM	miR-21-3p	3897	406995	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	miR-21-3p is a positive regulator of L1CAM in several human carcinomas .
26770450	0	L1CAM	72,77	miR-503	0,7	L1CAM	miR-503	3897	574506	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-503 inhibits cell proliferation and invasion in glioma by targeting L1CAM .
21109948	0	L1CAM	126,131	transforming_growth_factor-b1	80,109	L1CAM	transforming growth factor-b1	3897	7040	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
22162396	0	L1TD1	20,25	LIN28	41,46	L1TD1	LIN28	54596	79727	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation .
21360711	0	L1_Cell_adhesion_molecule	0,25	L1CAM	27,32	L1 Cell adhesion molecule	L1CAM	3897	3897	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	L1_Cell_adhesion_molecule -LRB- L1CAM -RRB- expression at the cancer invasive front is a novel prognostic marker of pancreatic_ductal_adenocarcinoma .
27028855	0	L1_cell_adhesion_molecule	58,83	L1CAM	85,90	L1 cell adhesion molecule	L1CAM	3897	3897	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value and clinicopathologic characteristics of L1_cell_adhesion_molecule -LRB- L1CAM -RRB- in a large series of vulvar_squamous_cell_carcinomas .
9521424	0	L1_cell_adhesion_molecule	117,142	L1CAM	144,149	L1 cell adhesion molecule	L1CAM	3897	3897	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple exon screening using restriction endonuclease fingerprinting -LRB- REF -RRB- : detection of six novel mutations in the L1_cell_adhesion_molecule -LRB- L1CAM -RRB- gene .
22711166	0	L1_cell_adhesion_molecule	26,51	microRNA-146a	0,13	L1 cell adhesion molecule	microRNA-146a	3897	406938	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	microRNA-146a targets the L1_cell_adhesion_molecule and suppresses the metastatic potential of gastric_cancer .
15314173	0	L23	18,21	p53	32,35	L23	p53	9349	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition .
16134148	0	L2HGDH	6,12	L-2-hydroxyglutaric_aciduria	43,71	L2HGDH	L-2-hydroxyglutaric aciduria	79944	79944	Gene	Gene	mutations|nsubj|START_ENTITY mutations|nmod|END_ENTITY	Novel L2HGDH mutations in 21 patients with L-2-hydroxyglutaric_aciduria of Portuguese origin .
2456858	0	L3T4	31,35	B220	25,29	L3T4	B220	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Ontogeny and function of B220 + L3T4 + T-cell subset of MRL/Mp-lpr/lpr mice .
2456858	4	L3T4	780,784	B220	774,778	L3T4	B220	12504(Tax:10090)	19264(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ that|dep|cells that|nmod|END_ENTITY	The expression level of L3T4 antigen on the T subset was lower than that on B220 - L3T4 + cells , while the level of B220 antigen was similar to that of B220 + L3T4 - or B220 + Lyt_2 - cells .
1866603	0	L3T4	21,25	CD4	16,19	L3T4	CD4	12504(Tax:10090)	12504(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	A novel form of CD4 -LRB- L3T4 -RRB- mRNA in the murine fetal liver results in cell-surface expression of the L3T4 antigen .
2467816	0	L3T4	0,4	Ly-24	100,105	L3T4	Ly-24	12504(Tax:10090)	12505(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY express|nsubj|cells express|dobj|END_ENTITY	L3T4 + T cells promoting susceptibility to murine cutaneous_leishmaniasis express the surface marker Ly-24 -LRB- Pgp-1 -RRB- .
2879623	0	L3T4	89,93	Lyt-1	95,100	L3T4	Lyt-1	12504(Tax:10090)	12507(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Induction of `` innocent bystander '' cytotoxicity in nonimmune mice by adoptive transfer of L3T4 + Lyt-1 +2 - mammary tumor immune T-cells .
2942460	1	L3T4	209,213	Lyt-2	215,220	L3T4	Lyt-2	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	+|nummod|START_ENTITY END_ENTITY|nmod:npmod|+	The expression of L3T4 and Lyt-2 cell surface molecules separates T cells into two broad , non-overlapping subsets : typical T helper cells are L3T4 + Lyt-2 - whereas most T killer cells and their precursors are L3T4 - Lyt-2 + .
2602913	0	L3T4	65,69	Lyt2	59,63	L3T4	Lyt2	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|amod|END_ENTITY	Cyclosporine_A prevents the generation of single positive -LRB- Lyt2 + L3T4 - , Lyt2 - L3T4 + -RRB- mature T cells , but not single positive -LRB- Lyt2 + T3 - -RRB- Immature thymocytes , in newborn mice .
2602913	0	L3T4	65,69	Lyt2	72,76	L3T4	Lyt2	12504(Tax:10090)	12525(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|dep|END_ENTITY	Cyclosporine_A prevents the generation of single positive -LRB- Lyt2 + L3T4 - , Lyt2 - L3T4 + -RRB- mature T cells , but not single positive -LRB- Lyt2 + T3 - -RRB- Immature thymocytes , in newborn mice .
3316384	0	L3T4	61,65	c-myb	28,33	L3T4	c-myb	12504(Tax:10090)	17863(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Molecular basis of elevated c-myb expression in the abnormal L3T4 - , Lyt-2 - T lymphocytes of autoimmune mice .
11756152	0	L540	116,120	CD30	0,4	IL-4	CD30	3565	943	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 .
11756152	0	L540	116,120	CXCR4	50,55	IL-4	CXCR4	3565	7852	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 .
1811340	0	LACI	56,60	lipoprotein-associated_coagulation_inhibitor	10,54	LACI	lipoprotein-associated coagulation inhibitor	7035	7035	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of lipoprotein-associated_coagulation_inhibitor -LRB- LACI -RRB- on thromboplastin-induced coagulation of normal and hemophiliac plasmas .
26603571	0	LACTB	125,130	THP-1	134,139	LACTB	THP-1	114294	2736	Gene	Gene	START_ENTITY|nmod|macrophages macrophages|compound|END_ENTITY	MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte_chemoattractant_protein-1 production by targeting inhibiting LACTB in THP-1 macrophages .
17968322	0	LAF4	54,58	AML1	28,32	LAF4	AML1	3899	861	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of the novel AML1 fusion partner gene , LAF4 , a fusion partner of MLL , in childhood T-cell_acute_lymphoblastic_leukemia with t -LRB- 2 ; 21 -RRB- -LRB- q11 ; q22 -RRB- by bubble PCR method for cDNA .
17968322	0	LAF4	54,58	MLL	80,83	LAF4	MLL	3899	4297	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Identification of the novel AML1 fusion partner gene , LAF4 , a fusion partner of MLL , in childhood T-cell_acute_lymphoblastic_leukemia with t -LRB- 2 ; 21 -RRB- -LRB- q11 ; q22 -RRB- by bubble PCR method for cDNA .
18706403	0	LAG-1	29,34	hlh-6	54,59	LAG-1	hlh-6	177373(Tax:6239)	188539(Tax:6239)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. _ elegans .
7568229	0	LAG-2	37,42	APX-1	0,5	LAG-2	APX-1	178755(Tax:6239)	178759(Tax:6239)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis_elegans development .
26927558	0	LAG-3	32,37	CD14	51,55	LAG-3	CD14	3902	929	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	-LSB- Decreased expression levels of LAG-3 and CD49b on CD14 -LRB- + -RRB- ; cells in peripheral blood of patients with recurrent spontaneous_abortion -RSB- .
12775570	0	LAG-3	91,96	CD223	106,111	LAG-3	CD223	3902	3902	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	MHC class II signal transduction in human dendritic cells induced by a natural ligand , the LAG-3 protein -LRB- CD223 -RRB- .
9647260	0	LAG-3	30,35	Lymphocyte_activation_gene-3	0,28	LAG-3	Lymphocyte activation gene-3	3902	3902	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lymphocyte_activation_gene-3 -LRB- LAG-3 -RRB- expression and IFN-gamma production are variably coregulated in different human T lymphocyte subpopulations .
9341765	0	LAG-3	95,100	lymphocyte_activation_gene-3	65,93	LAG-3	lymphocyte activation gene-3	3902	3902	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Opposite role for interleukin-4 and interferon-gamma on CD30 and lymphocyte_activation_gene-3 -LRB- LAG-3 -RRB- expression by activated naive T cells .
25695838	0	LAG3	31,35	CD4	18,21	LAG3	CD4	3902	920	Gene	Gene	START_ENTITY|nsubj|CD25 CD25|compound|END_ENTITY	TGF-b3-expressing CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- LAG3 -LRB- + -RRB- regulatory T cells control humoral immune responses .
21131422	0	LAGE-1	58,64	CD4	33,36	LAGE-1	CD4	30848	920	Gene	Gene	T|nmod|START_ENTITY T|nsubj|hierarchy hierarchy|nmod|+ +|compound|END_ENTITY	Epitope hierarchy of spontaneous CD4 + T cell responses to LAGE-1 .
24380839	0	LAIR-1	12,18	CD305	20,25	LAIR-1	CD305	3903	3903	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of LAIR-1 -LRB- CD305 -RRB- in T cells and monocytes/macrophages in patients with rheumatoid_arthritis .
15939744	0	LAIR-1	28,34	CD85j	21,26	LAIR-1	CD85j	3903	10859	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	Inhibitory receptors CD85j , LAIR-1 , and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes .
23778340	0	LAIR-1	67,73	leukocyte-associated_immunoglobulin-like_receptor-1	14,65	LAIR-1	leukocyte-associated immunoglobulin-like receptor-1	3903	3903	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of leukocyte-associated_immunoglobulin-like_receptor-1 -LRB- LAIR-1 -RRB- on osteoclasts and its potential role in rheumatoid_arthritis .
24415628	0	LAIR1	25,30	CD305	32,37	LAIR1	CD305	3903	3903	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of LAIR1 -LRB- CD305 -RRB- as assessed by flow cytometry in a prospective series of patients with chronic_lymphocytic_leukemia .
1658591	0	LAK	50,53	IL-2	34,38	LAK	IL-2	80216	3558	Gene	Gene	cell|compound|START_ENTITY cell|amod|END_ENTITY	-LSB- Adopted immunochemotherapy using IL-2 and spleen LAK cell -- randomized study -RSB- .
2031145	0	LAK	55,58	IL-2	111,115	LAK	IL-2	320982(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY cells|nmod|activity precursors|nmod|cells precursors|nmod|influence influence|nmod|END_ENTITY	Differentiation of macrophage precursors to cells with LAK activity under the influence of CSF-1 and high dose IL-2 .
2390269	0	LAK	20,23	IL-2	71,75	LAK	IL-2	80216	3558	Gene	Gene	cells|compound|START_ENTITY Generation|nmod|cells Generation|acl|using using|dobj|END_ENTITY	Generation of human LAK cells in tissue culture bags using recombinant IL-2 and serum free medium .
3262092	0	LAK	59,62	IL-2	35,39	LAK	IL-2	80216	3558	Gene	Gene	killer|appos|START_ENTITY Heterogeneity|dep|killer Heterogeneity|nmod|lymphokine lymphokine|appos|END_ENTITY	Heterogeneity of human lymphokine -LRB- IL-2 -RRB- - activated killer -LRB- LAK -RRB- precursors and regulation of their LAK induction by blood monocytes .
3262092	0	LAK	99,102	IL-2	35,39	LAK	IL-2	80216	3558	Gene	Gene	precursors|nmod|START_ENTITY killer|dep|precursors Heterogeneity|dep|killer Heterogeneity|nmod|lymphokine lymphokine|appos|END_ENTITY	Heterogeneity of human lymphokine -LRB- IL-2 -RRB- - activated killer -LRB- LAK -RRB- precursors and regulation of their LAK induction by blood monocytes .
8110993	0	LAK	61,64	IL-2	48,52	LAK	IL-2	71481(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Asialo-positive cells are overexpressed whereas IL-2 induced LAK activity is impaired in mice hyperimmunized with an immunomodulating mycobacterial fraction .
2788510	0	LAK	31,34	Interleukin-2	0,13	LAK	Interleukin-2	80216	3558	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Interleukin-2 with and without LAK cells in metastatic renal_cell_carcinoma : the Lyon first-year experience in 20 patients .
2563135	0	LAK	63,66	interleukin-2	33,46	LAK	interleukin-2	80216	3558	Gene	Gene	cells|compound|START_ENTITY Hypothyroidism|nmod|cells Hypothyroidism|nmod|therapy therapy|compound|END_ENTITY	Hypothyroidism and goitre during interleukin-2 therapy without LAK cells .
3264344	0	LAK	87,90	interleukin-2	148,161	LAK	interleukin-2	80216	3558	Gene	Gene	cell|compound|START_ENTITY cell|acl|generated generated|nmod|dose dose|nmod|END_ENTITY	Fractionated extract of Astragalus membranaceus , a Chinese medicinal herb , potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2 .
7754446	0	LAK	48,51	interleukin-2	20,33	LAK	interleukin-2	80216	3558	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Immunotherapy with interleukin-2 and allogenic LAK cells in a patient with acute_myeloblastic_leukemia -RSB- .
2591971	0	LAMA	23,27	laminin_A_chain	6,21	LAMA	laminin A chain	284217	284217	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human laminin_A_chain -LRB- LAMA -RRB- gene : chromosomal mapping to locus 18p11 .3 .
20556798	0	LAMB2	38,43	laminin_beta2	23,36	LAMB2	laminin beta2	3913	3913	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the human laminin_beta2 -LRB- LAMB2 -RRB- gene and the associated phenotypic spectrum .
10372560	0	LAMC2	135,140	gamma2	116,122	LAMC2	gamma2	16782(Tax:10090)	14406(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Laminin-5 promotes adhesion and migration of epithelial cells : identification of a migration-related element in the gamma2 chain gene -LRB- LAMC2 -RRB- with activity in transgenic_mice .
15844168	0	LAMP	63,67	limbic_system-associated_membrane_protein	20,61	LAMP	limbic system-associated membrane protein	29561(Tax:10116)	29561(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of the limbic_system-associated_membrane_protein -LRB- LAMP -RRB- in pigeon forebrain and midbrain .
23826410	0	LAMP-1	59,65	lysosomal-associated_membrane_protein-1	18,57	LAMP-1	lysosomal-associated membrane protein-1	3916	3916	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the lysosomal-associated_membrane_protein-1 -LRB- LAMP-1 -RRB- in astrocytomas .
12950108	0	LAMP-1	66,72	lysosomal_associated_membrane_protein	27,64	LAMP-1	lysosomal associated membrane protein	3916	3916	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of lysosomal_associated_membrane_protein -LRB- LAMP-1 -RRB- during mammalian spermiogenesis .
27069538	0	LAMP3	62,67	lysosome-associated_membrane_protein_3	22,60	LAMP3	lysosome-associated membrane protein 3	239739(Tax:10090)	239739(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The potential role of lysosome-associated_membrane_protein_3 -LRB- LAMP3 -RRB- on cardiac_remodelling .
2253878	0	LAP	0,3	C/EBP	27,32	LAP	C/EBP	7939	1050	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	LAP , a novel member of the C/EBP gene family , encodes a liver-enriched_transcriptional_activator_protein .
16540527	0	LAP	113,116	CD4	109,112	LAP	CD4	219103(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Recovery from experimental_allergic_encephalomyelitis is TGF-beta dependent and associated with increases in CD4 + LAP + and CD4 + CD25 + T cells .
16715091	0	LAP	90,93	CD4	79,82	LAP	CD4	7040	920	Gene	Gene	T|compound|START_ENTITY CD25|dep|T CD25|compound|END_ENTITY	Oral CD3-specific antibody suppresses autoimmune_encephalomyelitis by inducing CD4 + CD25 - LAP + T cells .
18941193	0	LAP	84,87	CD4	73,76	LAP	CD4	13708(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY lupus|parataxis|+ lupus|advcl|inducing inducing|dobj|CD25 CD25|compound|END_ENTITY	Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4 + CD25 - LAP + regulatory T cell and is associated with down-regulation of IL-17 + CD4 + ICOS + CXCR5 + follicular helper T cells .
21124798	0	LAP	22,25	CD4	47,50	LAP	CD4	219103(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
22552859	0	LAP	4,7	CD4	0,3	LAP	CD4	219103(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + LAP + and CD4 + CD25 + Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE - / - mice .
22939403	0	LAP	110,113	CD4	106,109	LAP	CD4	13708(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Hsp65-producing Lactococcus_lactis prevents experimental_autoimmune_encephalomyelitis in mice by inducing CD4 + LAP + regulatory T cells .
26004193	0	LAP	69,72	CD4	59,62	LAP	CD4	13708(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vitamin_A supplementation leads to increases in regulatory CD4 + Foxp3 + LAP + T cells in mice .
26582240	0	LAP	0,3	CD4	23,26	LAP	CD4	7040	920	Gene	Gene	Subset|compound|START_ENTITY Subset|nmod|CD25 CD25|compound|END_ENTITY	LAP TGF-Beta Subset of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- - -RRB- Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients .
19299332	0	LAP	52,55	FOXP3	120,125	LAP	FOXP3	7040	50943	Gene	Gene	latency-associated_peptide|appos|START_ENTITY expression|nmod|latency-associated_peptide expression|nmod|END_ENTITY	Selective expression of latency-associated_peptide -LRB- LAP -RRB- and IL-1 receptor type I/II -LRB- CD121a/CD121b -RRB- on activated human FOXP3 + regulatory T cells allows for their purification from expansion cultures .
21124798	0	LAP	22,25	Foxp3	74,79	LAP	Foxp3	219103(Tax:10090)	20371(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nmod|induction induction|amod|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
24064667	0	LAP	48,51	Foxp3	124,129	LAP	Foxp3	7040	50943	Gene	Gene	cells|compound|START_ENTITY exhibit|nsubj|cells exhibit|nmod|cells cells|amod|END_ENTITY	Highly prevalent colorectal_cancer-infiltrating LAP Foxp3 T cells exhibit more potent immunosuppressive activity than Foxp3 regulatory T cells .
24064667	0	LAP	48,51	Foxp3	55,60	LAP	Foxp3	7040	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Highly prevalent colorectal_cancer-infiltrating LAP Foxp3 T cells exhibit more potent immunosuppressive activity than Foxp3 regulatory T cells .
26004193	0	LAP	69,72	Foxp3	63,68	LAP	Foxp3	13708(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vitamin_A supplementation leads to increases in regulatory CD4 + Foxp3 + LAP + T cells in mice .
26582240	0	LAP	0,3	TGF-Beta	4,12	LAP	TGF-Beta	7040	7040	Gene	Gene	Subset|compound|START_ENTITY Subset|compound|END_ENTITY	LAP TGF-Beta Subset of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- - -RRB- Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients .
21124798	0	LAP	22,25	TGF-b	0,5	LAP	TGF-b	219103(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
26379781	0	LAP	12,15	TGF-b	6,11	LAP	TGF-b	219103(Tax:10090)	21803(Tax:10090)	Gene	Gene	products|compound|START_ENTITY serve|nsubj|products END_ENTITY|ccomp|serve	L -LRB- 59 -RRB- TGF-b LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice .
21420308	0	LAP	37,40	leucine_aminopeptidase	13,35	LAP	leucine aminopeptidase	7939	7939	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of leucine_aminopeptidase -LRB- LAP -RRB- like activity with wounding and methyl_jasmonate in pigeonpea -LRB- Cajanas cajan -RRB- suggests the role of these enzymes in plant defense in leguminosae .
3798485	0	LAP	38,41	leucine_aminopeptidase	14,36	LAP	leucine aminopeptidase	289668(Tax:10116)	289668(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of leucine_aminopeptidase -LRB- LAP -RRB- activity in the small intestines of rats exposed to dietary cadmium .
6813027	0	LAP	131,134	leucine_aminopeptidase	37,59	LAP	leucine aminopeptidase	7939	7939	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and quantification of leucine_aminopeptidase in aged normal and cataractous human lenses and ability of bovine lens LAP to cleave bovine crystallins .
20163606	0	LAP	53,56	lingual_antimicrobial_peptide	22,51	LAP	lingual antimicrobial peptide	403090(Tax:9913)	403090(Tax:9913)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of lingual_antimicrobial_peptide -LRB- LAP -RRB- in the bovine mammary gland .
2689224	1	LAP4	74,78	APE1	68,72	LAP4	APE1	853758(Tax:4932)	853758(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and regulation of the APE1 -LRB- LAP4 -RRB- structural gene .
21553234	0	LAPTM4A	0,7	hOCT2	23,28	LAPTM4A	hOCT2	9741	6582	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment .
25998573	0	LAPTM5	77,83	Lysosome-Associated_Protein_Transmembrane_5	32,75	LAPTM5	Lysosome-Associated Protein Transmembrane 5	7805	16792(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and Polymorphisms of Lysosome-Associated_Protein_Transmembrane_5 -LRB- LAPTM5 -RRB- in Patients with Systemic_Lupus_Erythematosus in a Chinese Population .
24923102	0	LAR	63,66	GLP-1_receptor	29,43	LAR	GLP-1 receptor	5792	2740	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	-LSB- Bydureon : first once weekly GLP-1_receptor agonist -LRB- exenatide LAR -RRB- -RSB- .
11158333	0	LAR	70,73	insulin_receptor	142,158	LAR	insulin receptor	5792	3643	Gene	Gene	domains|nmod|START_ENTITY tyrosine|dobj|domains tyrosine|nmod|dephosphorylation dephosphorylation|nmod|END_ENTITY	Distinct functions of the two protein tyrosine phosphatase domains of LAR -LRB- leukocyte common antigen-related -RRB- on tyrosine dephosphorylation of insulin_receptor .
7769120	0	LAR	70,73	insulin_receptor	100,116	LAR	insulin receptor	5792	3643	Gene	Gene	abundance|nmod|START_ENTITY accounts|nsubj|abundance accounts|nmod|END_ENTITY	Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin_receptor dephosphorylating activity in adipose tissue of obese human subjects .
8995282	0	LAR	103,106	insulin_receptor	35,51	LAR	insulin receptor	5792	3643	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Functional association between the insulin_receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells .
9023010	0	LAR	97,100	insulin_receptor	15,31	LAR	insulin receptor	360406(Tax:10116)	24954(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|activation activation|compound|END_ENTITY	Suppression of insulin_receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells .
9207225	0	LAR	33,36	insulin_receptor	59,75	LAR	insulin receptor	360406(Tax:10116)	24954(Tax:10116)	Gene	Gene	has|nsubj|START_ENTITY has|dobj|impact impact|nmod|dephosphorylation dephosphorylation|compound|END_ENTITY	The protein tyrosine phosphatase LAR has a major impact on insulin_receptor dephosphorylation .
1486801	0	LAR	61,64	leukocyte_antigen-related_tyrosine_phosphatase	13,59	LAR	leukocyte antigen-related tyrosine phosphatase	5792	5792	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for leukocyte_antigen-related_tyrosine_phosphatase -LRB- LAR -RRB- is localized to human chromosome 1p32 , a region frequently deleted in tumors of neuroectodermal origin .
10320483	0	LAR	35,38	p130Cas	96,103	LAR	p130Cas	5792	9564	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Transmembrane_tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas .
10064080	0	LARC	66,70	liver_and_activation-regulated_chemokine	24,64	LARC	liver and activation-regulated chemokine	20297(Tax:10090)	20297(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Selective expression of liver_and_activation-regulated_chemokine -LRB- LARC -RRB- in intestinal epithelium in mice and humans .
26483157	0	LARG	65,69	Cdk1	74,78	LARG	Cdk1	23365	983	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Mitotic-dependent phosphorylation of leukemia-associated_RhoGEF -LRB- LARG -RRB- by Cdk1 .
24740538	0	LARG	66,70	GEF	61,64	LARG	GEF	69632(Tax:10090)	16800(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Jun_kinase-induced overexpression of leukemia-associated Rho GEF -LRB- LARG -RRB- mediates sustained hypercontraction of longitudinal smooth muscle in inflammation .
24585879	0	LARG	45,49	RhoA	4,8	LARG	RhoA	23365	387	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	The RhoA guanine_nucleotide exchange factor , LARG , mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration .
25143398	0	LARG	16,20	TGF-b	0,5	LARG	TGF-b	23365	7040	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TGF-b regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion .
26483157	0	LARG	65,69	leukemia-associated_RhoGEF	37,63	LARG	leukemia-associated RhoGEF	23365	23365	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Mitotic-dependent phosphorylation of leukemia-associated_RhoGEF -LRB- LARG -RRB- by Cdk1 .
25531318	0	LARP1	0,5	mTOR	39,43	LARP1	mTOR	23367	21977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression .
26644407	0	LARP4	0,5	TNFa	22,26	LARP4	TNFa	113251	7124	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	LARP4 is regulated by TNFa in a Tristetraprolin -LRB- TTP -RRB- - dependent manner .
26644407	0	LARP4	0,5	Tristetraprolin	32,47	LARP4	Tristetraprolin	113251	7538	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	LARP4 is regulated by TNFa in a Tristetraprolin -LRB- TTP -RRB- - dependent manner .
26932461	0	LARP6	32,37	Akt	0,3	LARP6	Akt	55323	207	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Akt mediated phosphorylation of LARP6 ; critical step in biosynthesis of type I collagen .
15919814	0	LARS2	56,61	leucyl_tRNA_synthetase	32,54	LARS2	leucyl tRNA synthetase	23395	51520	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence that the mitochondrial leucyl_tRNA_synthetase -LRB- LARS2 -RRB- gene represents a novel type 2 diabetes susceptibility gene .
22897902	0	LASP-1	73,79	LIM_and_SH3_protein_1	50,71	LASP-1	LIM and SH3 protein 1	3927	3927	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Role of hepatitis_B virus X protein in regulating LIM_and_SH3_protein_1 -LRB- LASP-1 -RRB- expression to mediate proliferation and migration of hepatoma cells .
26797416	0	LASP-1	0,6	S100P	122,127	LASP-1	S100P	3927	6286	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	LASP-1 induces proliferation , metastasis and cell cycle arrest at the G2/M phase in gallbladder_cancer by down-regulating S100P via the PI3K/AKT pathway .
20924110	0	LASP1	31,36	LIM_and_SH3_protein_1	8,29	LASP1	LIM and SH3 protein 1	3927	3927;10611	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of LIM_and_SH3_protein_1 -LRB- LASP1 -RRB- in the metastatic dissemination of medulloblastoma .
18677772	0	LASP2	37,42	LIM-nebulette	22,35	LASP2	LIM-nebulette	10529	10529	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Ectopic expression of LIM-nebulette -LRB- LASP2 -RRB- reveals roles in cell migration and spreading .
12209631	0	LAT	106,109	CD2	181,184	LAT	CD2	27040	914	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	Lipid rafts as the signaling scaffold for NK cell activation : tyrosine phosphorylation and association of LAT with phosphatidylinositol_3-kinase and phospholipase C-gamma following CD2 stimulation .
10567557	0	LAT	0,3	GPVI	119,123	LAT	GPVI	16797(Tax:10090)	243816(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	LAT is required for tyrosine phosphorylation of phospholipase_cgamma2 and platelet activation by the collagen receptor GPVI .
9846483	0	LAT	0,3	PLCgamma1	47,56	LAT	PLCgamma1	27040	5335	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway .
10358158	0	LAT	73,76	ZAP-70	24,30	LAT	ZAP-70	16797(Tax:10090)	22637(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes .
17492476	0	LAT	22,25	ZAP-70	14,20	LAT	ZAP-70	27040	7535	Gene	Gene	SLP-76|appos|START_ENTITY SLP-76|compound|END_ENTITY	Prevalence of ZAP-70 , LAT , SLP-76 , and DNA_methyltransferase_1 expression in CD4 + T cells of patients with systemic_lupus_erythematosus .
9489702	0	LAT	0,3	ZAP-70	9,15	LAT	ZAP-70	27040	7535	Gene	Gene	START_ENTITY|dep|substrate substrate|amod|tyrosine tyrosine|amod|END_ENTITY	LAT : the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation .
11368773	0	LAT	44,47	Zap-70	12,18	LAT	Zap-70	27040	7535	Gene	Gene	Mapping|nmod|START_ENTITY Mapping|dobj|sites sites|amod|END_ENTITY	Mapping the Zap-70 phosphorylation sites on LAT -LRB- linker for activation of T cells -RRB- required for recruitment and activation of signalling proteins in T cells .
12209631	0	LAT	106,109	phosphatidylinositol_3-kinase	115,144	LAT	phosphatidylinositol 3-kinase	27040	5294	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|amod|END_ENTITY	Lipid rafts as the signaling scaffold for NK cell activation : tyrosine phosphorylation and association of LAT with phosphatidylinositol_3-kinase and phospholipase C-gamma following CD2 stimulation .
26054677	0	LAT-1	72,77	MicroRNA-126	0,12	LAT-1	MicroRNA-126	8140	406913	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-126 inhibits cell proliferation in gastric_cancer by targeting LAT-1 .
25901202	0	LAT1	70,74	CD147	21,26	LAT1	CD147	8140	682	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between CD147 and expression of amino_acid transporters -LRB- LAT1 and ASCT2 -RRB- in patients with pancreatic_cancer .
26279759	0	LAT1	60,64	L-type_amino_acid_transporter_1	27,58	LAT1	L-type amino acid transporter 1	8140	8140	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of L-type_amino_acid_transporter_1 -LRB- LAT1 -RRB- expression in patients with ovarian_tumors .
26279759	0	LAT1	60,64	L-type_amino_acid_transporter_1	27,58	LAT1	L-type amino acid transporter 1	8140	8140	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of L-type_amino_acid_transporter_1 -LRB- LAT1 -RRB- expression in patients with ovarian_tumors .
17485849	0	LATERAL_ORGAN_BOUNDARIES	92,116	AS2/LOB	83,90	LATERAL ORGAN BOUNDARIES	AS2/LOB	836429(Tax:3702)	842873;836429	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	A link between cytokinin and ASL9 -LRB- ASYMMETRIC_LEAVES_2_LIKE_9 -RRB- that belongs to the AS2/LOB -LRB- LATERAL_ORGAN_BOUNDARIES -RRB- family genes in Arabidopsis_thaliana .
21750030	0	LATE_MERISTEM_IDENTITY2	0,23	APETALA1	61,69	LATE MERISTEM IDENTITY2	APETALA1	825297(Tax:3702)	843244(Tax:3702)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	LATE_MERISTEM_IDENTITY2 acts together with LEAFY to activate APETALA1 .
21750030	0	LATE_MERISTEM_IDENTITY2	0,23	LEAFY	43,48	LATE MERISTEM IDENTITY2	LEAFY	825297(Tax:3702)	836307(Tax:3702)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	LATE_MERISTEM_IDENTITY2 acts together with LEAFY to activate APETALA1 .
16674920	0	LATS1	28,33	MOB1	56,60	LATS1	MOB1	9113	55233	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	The human tumour suppressor LATS1 is activated by human MOB1 at the membrane .
25119020	0	LATS1	55,60	large_tumor_suppressor_1	29,53	LATS1	large tumor suppressor 1	9113	9113	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Biallelic alterations of the large_tumor_suppressor_1 -LRB- LATS1 -RRB- gene in infiltrative , but not superficial , basal_cell_carcinomas in a Japanese patient with nevoid_basal_cell_carcinoma_syndrome .
22888524	0	LATS2	86,91	MiR-195	0,7	LATS2	MiR-195	26524	406971	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-195 regulates cell apoptosis of human hepatocellular_carcinoma cells by targeting LATS2 .
25179841	0	LATS2	71,76	MiR-25	0,6	LATS2	MiR-25	26524	407014	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-25 promotes ovarian_cancer proliferation and motility by targeting LATS2 .
25782587	0	LATS2	0,5	TNF-alpha	17,26	LATS2	TNF-alpha	26524	7124	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral_squamous_cell_carcinoma .
25655308	0	LB-1	0,4	HIF-1a	66,72	LB-1	HIF-1a	26586	3091	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	LB-1 Exerts Antitumor Activity in Pancreatic_Cancer by Inhibiting HIF-1a and Stat3 Signaling .
12500535	0	LB1	58,61	CKAP2	51,56	LB1	CKAP2	26586	26586	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- The structure of the human oncogenesis-associated CKAP2 -LRB- LB1 -RRB- gene -RSB- .
25897893	0	LB100	0,5	PP2A	37,41	LB100	PP2A	1154026(Tax:189518)	5524	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	LB100 , a small molecule inhibitor of PP2A with potent chemo - and radio-sensitizing potential .
25897893	0	LB100	0,5	PP2A	37,41	LB100	PP2A	1154026(Tax:189518)	5524	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	LB100 , a small molecule inhibitor of PP2A with potent chemo - and radio-sensitizing potential .
26059335	0	LBD16	0,5	AUX1	38,42	LBD16	AUX1	818843(Tax:3702)	818390(Tax:3702)	Gene	Gene	Downstream|compound|START_ENTITY Downstream|nmod|END_ENTITY	LBD16 and LBD18 Act Downstream of the AUX1 and LAX3 Auxin Influx Carriers to Control Lateral Root Development in Arabidopsis_thaliana .
23299420	0	LBD18	35,40	EXPANSIN14	21,31	LBD18	EXPANSIN14	819150(Tax:3702)	835731(Tax:3702)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Direct activation of EXPANSIN14 by LBD18 in the gene regulatory network of lateral root formation in Arabidopsis .
11940594	0	LBM180	18,24	ABCA3	126,131	LBM180	ABCA3	21	21	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of LBM180 , a lamellar body limiting membrane protein of alveolar_type_II cells , as the ABC transporter protein ABCA3 .
23742867	0	LBP	129,132	BPI	88,91	LBP	BPI	3929	671	Gene	Gene	lipopolysaccharide-binding_protein|appos|START_ENTITY /|dobj|lipopolysaccharide-binding_protein /|nsubj|analysis analysis|appos|END_ENTITY	Identification and expression analysis on bactericidal_permeability-increasing_protein -LRB- BPI -RRB- / lipopolysaccharide-binding_protein -LRB- LBP -RRB- of ark shell , Scapharca broughtonii .
7507806	0	LBP	108,111	BPI	63,66	LBP	BPI	3929	671	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Plasma levels of bactericidal/permeability-increasing _ protein -LRB- BPI -RRB- and lipopolysaccharide-binding protein -LRB- LBP -RRB- during hemodialysis .
8432532	0	LBP	54,57	BPI	113,116	LBP	BPI	3929	671	Gene	Gene	lipopolysaccharide_binding_protein|appos|START_ENTITY lipopolysaccharide_binding_protein|appos|END_ENTITY	The genes for the lipopolysaccharide_binding_protein -LRB- LBP -RRB- and the bactericidal_permeability_increasing_protein -LRB- BPI -RRB- are encoded in the same region of human chromosome 20 .
9240454	0	LBP	84,87	BPI	139,142	LBP	BPI	3929	671	Gene	Gene	lipopolysaccharide_binding_protein|appos|START_ENTITY lipopolysaccharide_binding_protein|appos|END_ENTITY	The genomic organization of the genes for human lipopolysaccharide_binding_protein -LRB- LBP -RRB- and bactericidal_permeability_increasing_protein -LRB- BPI -RRB- is highly conserved .
19115038	0	LBP	57,60	CD14	34,38	LBP	CD14	29469(Tax:10116)	60350(Tax:10116)	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Screening of mimetic peptides for CD14 binding site with LBP and antiendotoxin activity of mimetic peptide in vivo and in vitro .
7515085	0	LBP	79,82	LPS-binding_protein	58,77	LBP	LPS-binding protein	3929	3929	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Radioimmunoassay versus flow cytometric assay to quantify LPS-binding_protein -LRB- LBP -RRB- concentrations in human plasma .
19560454	0	LBP	36,39	Lipopolysaccharide-binding_protein	0,34	LBP	Lipopolysaccharide-binding protein	3929	3929	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lipopolysaccharide-binding_protein -LRB- LBP -RRB- gene polymorphisms : rapid genotyping by real-time PCR and association with infective_endocarditis .
12856185	0	LBP	54,57	lipopolysaccharide-binding_protein	18,52	LBP	lipopolysaccharide-binding protein	3929	3929	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Clinical value of lipopolysaccharide-binding_protein -LRB- LBP -RRB- determinations in acute pancreatitis .
22733492	0	LBP	49,52	lipopolysaccharide-binding_protein	13,47	LBP	lipopolysaccharide-binding protein	512242(Tax:9913)	512242(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in lipopolysaccharide-binding_protein -LRB- LBP -RRB- gene change the susceptibility to clinical mastitis in Chinese Holstein .
9287245	0	LBP	81,84	lipopolysaccharide_binding_protein	45,79	LBP	lipopolysaccharide binding protein	3929	3929	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Control of transcriptional activation of the lipopolysaccharide_binding_protein -LRB- LBP -RRB- gene by proinflammatory cytokines .
27059139	0	LBR	43,46	lamin_B_receptor	25,41	LBR	lamin B receptor	3930	3930	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Aberrant localization of lamin_B_receptor -LRB- LBR -RRB- in cellular senescence in human cells .
20820887	0	LBX2	40,44	ladybird-like_homeobox_2	14,38	LBX2	ladybird-like homeobox 2	16815(Tax:10090)	16815(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ladybird-like_homeobox_2 -LRB- LBX2 -RRB- during ovarian development and folliculogenesis in the mouse .
20479004	0	LC-3	34,38	Pin1	21,25	LC-3	Pin1	84557	5300	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast_cancer .
8084610	0	LC-PTP	23,29	HePTP	31,36	LC-PTP	HePTP	5778	5778	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the human LC-PTP -LRB- HePTP -RRB- gene : similarity in genomic organization within protein-tyrosine phosphatase genes .
19696020	0	LC3	27,30	AKAP-Lbc	65,73	LC3	AKAP-Lbc	84557	11214	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-Lbc .
11060023	0	LC3	0,3	Apg8p	36,41	LC3	Apg8p	84557	852200(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	LC3 , a mammalian homologue of yeast Apg8p , is localized in autophagosome membranes after processing .
16874114	0	LC3	67,70	Atg4B	103,108	LC3	Atg4B	25291(Tax:10116)	316640(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues .
16874114	0	LC3	67,70	Atg4B	31,36	LC3	Atg4B	25291(Tax:10116)	316640(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues .
18768752	0	LC3	42,45	Atg4B	3,8	LC3	Atg4B	84557	23192	Gene	Gene	paralogues|nummod|START_ENTITY lipidation|nmod|paralogues hampers|dobj|lipidation hampers|nsubj|mutant mutant|amod|END_ENTITY	An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure .
26772398	0	LC3	42,45	CD44	60,64	LC3	CD44	84557	960	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Decreased expression of autophagy protein LC3 and stemness -LRB- CD44 + / CD24 - / low -RRB- indicate poor prognosis in triple-negative_breast_cancer .
20153330	0	LC3	67,70	PINK1	0,5	LC3	PINK1	84557	65018	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy .
24796733	0	LC3	21,24	STAT3	0,5	LC3	STAT3	84557	6774	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	STAT3 down regulates LC3 to inhibit autophagy and pancreatic_cancer cell growth .
22421968	0	LC3	45,48	TP53INP1	0,8	LC3	TP53INP1	84557	94241	Gene	Gene	proteins|compound|START_ENTITY interacts|nmod|proteins interacts|nsubj|END_ENTITY	TP53INP1 , a tumor suppressor , interacts with LC3 and ATG8-family proteins through the LC3-interacting region -LRB- LIR -RRB- and promotes autophagy-dependent cell death .
26431026	0	LC3C	23,27	TECPR2	0,6	LC3C	TECPR2	440738	9895	Gene	Gene	Cooperates|nmod|START_ENTITY Cooperates|compound|END_ENTITY	TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export .
21971545	0	LC8	0,3	DYNLL1	24,30	LC8	DYNLL1	8655	8655	Gene	Gene	chain|compound|START_ENTITY chain|appos|END_ENTITY	LC8 dynein light chain -LRB- DYNLL1 -RRB- binds to the C-terminal domain of ATM-interacting_protein -LRB- ATMIN/ASCIZ -RRB- and regulates its subcellular localization .
23038268	0	LC8	22,25	light_chain_1	7,20	LC8	light chain 1	8655	8655	Gene	Gene	association|compound|START_ENTITY association|amod|END_ENTITY	Dynein light_chain_1 -LRB- LC8 -RRB- association enhances microtubule stability and promotes microtubule bundling .
278893	0	LCAT	38,42	Lecithin-cholesterol_acyltransferase	0,36	LCAT	Lecithin-cholesterol acyltransferase	3931	3931	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Lecithin-cholesterol_acyltransferase -LRB- LCAT -RRB- activity in chronic_uremia .
19682715	0	LCAT	38,42	Lecithin_cholesterol_acyltransferase	0,36	LCAT	Lecithin cholesterol acyltransferase	3931	3931	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Lecithin_cholesterol_acyltransferase -LRB- LCAT -RRB- activity as a predictor for ketosis and parturient haemoglobinuria in Egyptian water buffaloes .
24383078	0	LCAT	38,42	Lecithin_cholesterol_acyltransferase	0,36	LCAT	Lecithin cholesterol acyltransferase	3931	3931	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Lecithin_cholesterol_acyltransferase -LRB- LCAT -RRB- activity in the presence of Apo-AI-derived peptides exposed to disorder-order conformational transitions .
24513206	0	LCAT	38,42	Lecithin_cholesterol_acyltransferase	0,36	LCAT	Lecithin cholesterol acyltransferase	3931	3931	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Lecithin_cholesterol_acyltransferase -LRB- LCAT -RRB- activity in the presence of Apo-AI-derived peptides exposed to disorder-order conformational transitions .
11018467	0	LCAT	168,172	apolipoprotein_A-I	135,153	LCAT	apolipoprotein A-I	24530(Tax:10116)	25081(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein_A-I transgenic rats is diminished through dose-dependent apolipoprotein_A-I activation of LCAT .
1226995	0	LCAT	89,93	lecithin-cholesterol_acyltransferase	51,87	LCAT	lecithin-cholesterol acyltransferase	100008978(Tax:9986)	100008978(Tax:9986)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Effect of essential phospholipids -LRB- EPL -RRB- on plasma lecithin-cholesterol_acyltransferase -LRB- LCAT -RRB- activity in vivo and in vitro in the rabbit -RSB- .
8326012	0	LCAT	83,87	lecithin-cholesterol_acyltransferase	45,81	LCAT	lecithin-cholesterol acyltransferase	3931	3931	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fish_eye_syndrome : a molecular defect in the lecithin-cholesterol_acyltransferase -LRB- LCAT -RRB- gene associated with normal alpha-LCAT-specific activity .
8609388	0	LCK	73,76	EMT	115,118	LCK	EMT	3932	3702	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	The EMT/ITK/TSK -LRB- EMT -RRB- tyrosine kinase is activated during TCR signaling : LCK is required for optimal activation of EMT .
24688028	0	LCK	46,49	NTB-A	53,58	LCK	NTB-A	3932	114836	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced_cell_death .
16446380	0	LCK	75,78	T_cell-specific_adapter_protein	22,53	LCK	T cell-specific adapter protein	16818(Tax:10090)	27371(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Essential role of the T_cell-specific_adapter_protein in the activation of LCK in peripheral T cells .
15331563	0	LCK	73,76	lymphocyte-specific_protein_tyrosine_kinase	28,71	LCK	lymphocyte-specific protein tyrosine kinase	16818(Tax:10090)	16818(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis of the lymphocyte-specific_protein_tyrosine_kinase -LRB- LCK -RRB- gene in type 1 diabetes .
20971076	0	LCK	53,56	lymphocyte-specific_protein_tyrosine_kinase	8,51	LCK	lymphocyte-specific protein tyrosine kinase	3932	3932	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of lymphocyte-specific_protein_tyrosine_kinase -LRB- LCK -RRB- in the expansion of glioma-initiating cells by fractionated radiation .
21044074	0	LCMT1	52,57	phosphatase_2A	22,36	LCMT1	phosphatase 2A	51451	5524	Gene	Gene	methylation|nmod|START_ENTITY methylation|amod|END_ENTITY	Regulation of protein phosphatase_2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells .
16400612	0	LCT	56,59	lactase	42,49	LCT	lactase	3938	3938	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the translated region of the lactase gene -LRB- LCT -RRB- underlie congenital_lactase_deficiency .
19161632	0	LCT	42,45	lactase	28,35	LCT	lactase	3938	3938	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Four novel mutations in the lactase gene -LRB- LCT -RRB- underlying congenital_lactase_deficiency -LRB- CLD -RRB- .
26215149	0	LCT	42,45	lactase	28,35	LCT	lactase	3938	3938	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation within the lactase gene -LRB- LCT -RRB- : the first report of congenital_lactase_deficiency diagnosed in Central Europe .
17934640	0	LCT	117,120	lactase-phlorizin_hydrolase	88,115	LCT	lactase-phlorizin hydrolase	3938	3938	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Correlation between lactose absorption and the C/T -13910 and G/A -22018 mutations of the lactase-phlorizin_hydrolase -LRB- LCT -RRB- gene in adult-type hypolactasia .
8843546	0	LD78	72,76	macrophage_inflammatory_protein-1_alpha	31,70	LD78	macrophage inflammatory protein-1 alpha	414062	6348	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The inhibitory effect of human macrophage_inflammatory_protein-1_alpha -LRB- LD78 -RRB- on acute_myeloid_leukemia cells in vitro .
9192621	0	LDH-A	25,30	c-Myc	0,5	LDH-A	c-Myc	3939	4609	Gene	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	c-Myc transactivation of LDH-A : implications for tumor metabolism and growth .
12441634	0	LDH-A	44,49	lactate_dehydrogenase	21,42	LDH-A	lactate dehydrogenase	102094829	102094829	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	PCR-RFLPs within the lactate_dehydrogenase -LRB- LDH-A -RRB- gene of the domestic_pigeon -LRB- Columba_livia var .
17434848	0	LDL-C	49,54	ACTG	84,88	LDL-C	ACTG	22796	71	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|dep|END_ENTITY	Comparison of direct and indirect measurement of LDL-C in HIV-infected individuals : ACTG 5087 .
25097526	0	LDL-R	76,81	Low_Density_Lipoprotein_Receptor	42,74	LDL-R	Low Density Lipoprotein Receptor	3949	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single step PCR for the identification of Low_Density_Lipoprotein_Receptor -LRB- LDL-R -RRB- gene mutations .
8767445	0	LDL-R	93,98	low_density_lipoprotein_receptor	59,91	LDL-R	low density lipoprotein receptor	3949	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Rapid characterization of disease-causing mutations in the low_density_lipoprotein_receptor -LRB- LDL-R -RRB- gene by overexpression in COS cells .
18602894	0	LDL-receptor	25,37	SREBP-2	66,73	LDL-receptor	SREBP-2	3949	6721	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Rapamycin down-regulates LDL-receptor expression independently of SREBP-2 .
21549101	5	LDLR	869,873	Angptl4	878,885	LDLR	Angptl4	16835(Tax:10090)	57875(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Fasting total cholesterol , VLDL-C , LDL-C , HDL-C and TG levels were decreased in LDLR -LRB- - / - -RRB- Angptl4 -LRB- - / - -RRB- mice compared with LDLR -LRB- - / - -RRB- Angptl4 -LRB- + / + -RRB- mice .
18217154	0	LDLR	60,64	C-reactive_protein	13,31	LDLR	C-reactive protein	3949	1401	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	No effect of C-reactive_protein on early atherosclerosis in LDLR - / - / human C-reactive_protein transgenic_mice .
18217154	0	LDLR	60,64	C-reactive_protein	76,94	LDLR	C-reactive protein	3949	1401	Gene	Gene	effect|nmod|START_ENTITY effect|parataxis|transgenic_mice transgenic_mice|amod|END_ENTITY	No effect of C-reactive_protein on early atherosclerosis in LDLR - / - / human C-reactive_protein transgenic_mice .
25714599	0	LDLR	149,153	CD11c	102,107	LDLR	CD11c	16835(Tax:10090)	16411(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Probucol protects against atherosclerosis through lipid-lowering and suppressing immune maturation of CD11c + dendritic cells in STZ-induced diabetic LDLR - / - mice .
11247302	0	LDLR	32,36	Disabled-2	0,10	LDLR	Disabled-2	3949	1601	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2 .
8100212	0	LDLR	66,70	LDL_receptor	52,64	LDLR	LDL receptor	3949	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Two new polymorphisms in the coding sequence of the LDL_receptor -LRB- LDLR -RRB- gene .
11137106	0	LDLR	39,43	Low-density_lipoprotein_receptor	0,32	LDLR	Low-density lipoprotein receptor	3949	3949	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Low-density_lipoprotein_receptor gene -LRB- LDLR -RRB- world-wide website in familial_hypercholesterolaemia : update , new features and mutation analysis .
19751783	0	LDLR	52,56	MCP-1	37,42	LDLR	MCP-1	16835(Tax:10090)	17224(Tax:10090)	Gene	Gene	level|nmod|START_ENTITY level|compound|END_ENTITY	Ghrelin vaccination decreases plasma MCP-1 level in LDLR -LRB- - / - -RRB- - mice .
20498851	0	LDLR	82,86	PCSK9	63,68	LDLR	PCSK9	16835(Tax:10090)	100102(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	A locked nucleic acid antisense oligonucleotide -LRB- LNA -RRB- silences PCSK9 and enhances LDLR expression in vitro and in vivo .
23085658	0	LDLR	98,102	TNF-a	66,71	LDLR	TNF-a	16835(Tax:10090)	21926(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	c-IAP1 binds and processes PCSK9 protein : linking the c-IAP1 in a TNF-a pathway to PCSK9-mediated LDLR degradation pathway .
20005558	0	LDLR	97,101	apoE	89,93	LDLR	apoE	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	effect|parataxis|START_ENTITY effect|nmod|END_ENTITY	The effect of the long term aspirin administration on the progress of atherosclerosis in apoE - / - LDLR - / - double knockout mouse .
19467224	0	LDLR	84,88	familial_hypercholesterolemia	97,126	LDLR	familial hypercholesterolemia	3949	3949	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	An apparent inconsistency in parent to offspring transmission of point mutations of LDLR gene in familial_hypercholesterolemia .
22378787	0	LDLR	80,84	low-density_lipoprotein_receptor	46,78	LDLR	low-density lipoprotein receptor	3949	3949	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Fibroblast_growth_factor-21 -LRB- FGF21 -RRB- regulates low-density_lipoprotein_receptor -LRB- LDLR -RRB- levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 -LRB- Cnpy2 -RRB- / Mylip-interacting saposin-like protein -LRB- Msap -RRB- .
25349780	0	LDLR	66,70	low-density_lipoprotein_receptor	32,64	LDLR	low-density lipoprotein receptor	3949	3949	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Quercetin-3-glucoside increases low-density_lipoprotein_receptor -LRB- LDLR -RRB- expression , attenuates proprotein_convertase_subtilisin / kexin_9 -LRB- PCSK9 -RRB- secretion , and stimulates LDL uptake by Huh7 human hepatocytes in culture .
15330118	0	LDLR	77,81	low_density_lipoprotein_receptor	43,75	LDLR	low density lipoprotein receptor	3949	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evolution of a hypervariable region of the low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene in humans and other hominoids .
17399720	0	LDLR	65,69	low_density_lipoprotein_receptor	31,63	LDLR	low density lipoprotein receptor	3949	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Two new large deletions in the low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene not revealed by PCR-based molecular diagnosis of familial_hypercholesterolemia .
22875854	0	LDLR	130,134	low_density_lipoprotein_receptor	96,128	LDLR	low density lipoprotein receptor	3949	3949	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	Loss - and gain-of-function PCSK9 variants : cleavage specificity , dominant negative effects , and low_density_lipoprotein_receptor -LRB- LDLR -RRB- degradation .
24529145	0	LDLR	55,59	low_density_lipoprotein_receptor	21,53	LDLR	low density lipoprotein receptor	3949	3949	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Presence and type of low_density_lipoprotein_receptor -LRB- LDLR -RRB- mutation influences the lipid profile and response to lipid-lowering therapy in Brazilian patients with heterozygous familial_hypercholesterolemia .
7868136	0	LDLR	88,92	low_density_lipoprotein_receptor	54,86	LDLR	low density lipoprotein receptor	3949	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new restriction-site polymorphism in exon 18 of the low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene .
26520906	0	LDLR	17,21	miR-27b	0,7	LDLR	miR-27b	16835(Tax:10090)	387221(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice .
22734645	0	LDLR-related_protein_10	0,23	amyloid_precursor_protein	42,67	LDLR-related protein 10	amyloid precursor protein	26020	351	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	LDLR-related_protein_10 -LRB- LRP10 -RRB- regulates amyloid_precursor_protein -LRB- APP -RRB- trafficking and processing : evidence for a role in Alzheimer 's _ disease .
23675033	0	LDL_Receptor	117,129	Apolipoprotein_E	100,116	LDL Receptor	Apolipoprotein E	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	Mice|compound|START_ENTITY Mice|compound|END_ENTITY	Medial Expression of TNF-a and TNF Receptors Precedes the Development of Atherosclerotic Lesions in Apolipoprotein_E / LDL_Receptor Double Knockout Mice .
26047795	0	LDL_Receptor-Related_Protein_6	0,30	Ret	41,44	LDL Receptor-Related Protein 6	Ret	16974(Tax:10090)	19713(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	LDL_Receptor-Related_Protein_6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic_Dysplasia .
12042130	0	LDL_receptor	55,67	APOE	29,33	LDL receptor	APOE	3949	348	Gene	Gene	mutations|compound|START_ENTITY genotype|nmod|mutations END_ENTITY|dobj|genotype	-LSB- Influence of plasma lipids , APOE genotype and type of LDL_receptor gene mutations on myocardial_infarction in subjects with familial_hypercholesterolemia -RSB- .
27014949	0	LDL_receptor	107,119	APOE	28,32	LDL receptor	APOE	3949	348	Gene	Gene	expression|compound|START_ENTITY down-regulation|nmod|expression causes|nmod|down-regulation causes|nsubj|mutation mutation|nmod|gene gene|amod|END_ENTITY	The p.Leu167del mutation in APOE gene causes autosomal dominant hypercholesterolemia by down-regulation of LDL_receptor expression in hepatocytes .
20197419	0	LDL_receptor	25,37	ApoE	143,147	LDL receptor	ApoE	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY study|nmod|mouse fed|nsubj|study fed|ccomp|reveals reveals|dobj|perturbations perturbations|acl:relcl|shared shared|nmod|mice mice|amod|END_ENTITY	Metabolomic study of the LDL_receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice .
22150227	0	LDL_receptor	86,98	ApoE	76,80	LDL receptor	ApoE	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	double|nmod:npmod|START_ENTITY model|dep|double lessons|parataxis|model lessons|nmod|END_ENTITY	Mixed testicular_atrophy related to atherosclerosis : first lessons from the ApoE -LRB- - / - -RRB- / LDL_receptor -LRB- - / - -RRB- double knockout mouse model .
3958613	0	LDL_receptor	96,108	ApoE	0,4	LDL receptor	ApoE	3949	348	Gene	Gene	lipoproteins|nmod|START_ENTITY the|nmod|lipoproteins necessary|nmod|the necessary|nsubj|END_ENTITY	ApoE is necessary and sufficient for the binding of large triglyceride-rich lipoproteins to the LDL_receptor ; apoB is unnecessary .
26582899	0	LDL_receptor	44,56	Idol	24,28	LDL receptor	Idol	16835(Tax:10090)	218203(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	The E3 ubiquitin ligase Idol controls brain LDL_receptor expression , ApoE clearance , and Ab_amyloidosis .
10894816	0	LDL_receptor	25,37	Interleukin-6	0,13	LDL receptor	Interleukin-6	3949	3569	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates LDL_receptor gene expression via activation of sterol-responsive and Sp1 binding elements .
8100212	0	LDL_receptor	52,64	LDLR	66,70	LDL receptor	LDLR	3949	3949	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Two new polymorphisms in the coding sequence of the LDL_receptor -LRB- LDLR -RRB- gene .
14764453	0	LDL_receptor	9,21	LR11	0,4	LDL receptor	LR11	16835(Tax:10090)	20660(Tax:10090)	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	LR11 , an LDL_receptor gene family member , is a novel regulator of smooth muscle cell migration .
23813961	0	LDL_receptor	19,31	NDRG1	0,5	LDL receptor	NDRG1	16835(Tax:10090)	17988(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	NDRG1 functions in LDL_receptor trafficking by regulating endosomal recycling and degradation .
18054331	0	LDL_receptor	35,47	OLR-1	54,59	LDL receptor	OLR-1	3949	4973	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	The G501C polymorphism of oxidized LDL_receptor gene -LSB- OLR-1 -RSB- is associated with susceptibility and serum C-reactive_protein concentration in Chinese essential hypertensives .
12646194	0	LDL_receptor	9,21	OLR1	28,32	LDL receptor	OLR1	3949	4973	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Oxidized LDL_receptor gene -LRB- OLR1 -RRB- is associated with the risk of myocardial_infarction .
17022953	0	LDL_receptor	31,43	OLR1	50,54	LDL receptor	OLR1	3949	4973	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	G501C polymorphism of oxidized LDL_receptor gene -LRB- OLR1 -RRB- and ischemic_stroke .
12524230	0	LDL_receptor	32,44	SCAP	59,63	LDL receptor	SCAP	3949	22937	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Synergistic activation of human LDL_receptor expression by SCAP ligand and cytokine oncostatin_M .
16211244	0	LDL_receptor	106,118	SCAP	52,56	LDL receptor	SCAP	3949	22937	Gene	Gene	gene|compound|START_ENTITY activation|nmod|gene activation|compound|END_ENTITY	Blockage of the ERK signaling pathway abrogates the SCAP ligand-induced transcriptional activation of the LDL_receptor gene in HepG2 cells .
10357834	0	LDL_receptor	0,12	apoE	37,41	LDL receptor	apoE	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	LDL_receptor binds newly synthesized apoE in macrophages .
12475897	0	LDL_receptor	95,107	apoE	108,112	LDL receptor	apoE	3949	348	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Pharmacological interference with intestinal bile_acid transport reduces plasma cholesterol in LDL_receptor / apoE deficiency .
10683382	0	LDL_receptor	16,28	apolipoprotein_B	32,48	LDL receptor	apolipoprotein B	16835(Tax:10090)	238055(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|amod|END_ENTITY	The role of the LDL_receptor in apolipoprotein_B secretion .
1744074	0	LDL_receptor	68,80	apolipoprotein_E	36,52	LDL receptor	apolipoprotein E	3949	348	Gene	Gene	binds|dobj|START_ENTITY END_ENTITY|acl:relcl|binds	A synthetic peptide mimic of plasma apolipoprotein_E that binds the LDL_receptor .
19013141	0	LDL_receptor	42,54	familial_hypercholesterolemia	67,96	LDL receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	A novel method for determining functional LDL_receptor activity in familial_hypercholesterolemia : application of the CD3/CD28 assay in lymphocytes .
22292497	0	LDL_receptor	140,152	gp96	66,70	LDL receptor	gp96	16835(Tax:10090)	22027(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members , including the LDL_receptor and LRP6 .
8725151	0	LDL_receptor	14,26	hepatocyte_growth_factor	61,85	LDL receptor	hepatocyte growth factor	3949	3082	Gene	Gene	expression|compound|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of LDL_receptor gene expression in HepG2 cells by hepatocyte_growth_factor .
14998783	0	LDL_receptor	69,81	insulin	90,97	LDL receptor	insulin	396801(Tax:9823)	397415(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL_receptor gene by insulin and LH in cultured porcine granulosa-luteal cells .
9374126	0	LDL_receptor	57,69	oncostatin_M	73,85	LDL receptor	oncostatin M	3949	5008	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Novel mechanism of transcriptional activation of hepatic LDL_receptor by oncostatin_M .
18281370	0	LDL_receptor-related_protein	27,55	Angiotensin_II	0,14	LDL receptor-related protein	Angiotensin II	4035	183	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Angiotensin_II upregulates LDL_receptor-related_protein -LRB- LRP1 -RRB- expression in the vascular wall : a new pro-atherogenic mechanism of hypertension .
14659844	0	LDL_receptor-related_protein	8,36	LRP	38,41	LDL receptor-related protein	LRP	4035	4035	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of LDL_receptor-related_protein -LRB- LRP -RRB- in coronary_atherosclerosis .
15698441	0	LDL_receptor-related_protein	27,55	LRP	57,60	LDL receptor-related protein	LRP	25167(Tax:10116)	25167(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of hepatic LDL_receptor-related_protein -LRB- LRP -RRB- in chronic_renal_failure .
17376415	0	LDL_receptor-related_protein	56,84	LRP1	86,90	LDL receptor-related protein	LRP1	4035	4035	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sterol regulatory element binding proteins downregulate LDL_receptor-related_protein -LRB- LRP1 -RRB- expression and LRP1-mediated aggregated LDL uptake by human macrophages .
18281370	0	LDL_receptor-related_protein	27,55	LRP1	57,61	LDL receptor-related protein	LRP1	4035	4035	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II upregulates LDL_receptor-related_protein -LRB- LRP1 -RRB- expression in the vascular wall : a new pro-atherogenic mechanism of hypertension .
7687998	0	LDL_receptor-related_protein	80,108	alpha_2-macroglobulin	109,130	LDL receptor-related protein	alpha 2-macroglobulin	16971(Tax:10090)	232345(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	A comparison of the roles of the low_density_lipoprotein _ -LRB- LDL -RRB- _ receptor and the LDL_receptor-related_protein / alpha_2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo .
10772929	0	LDL_receptor-related_protein	0,28	midkine	51,58	LDL receptor-related protein	midkine	16971(Tax:10090)	17242(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	LDL_receptor-related_protein as a component of the midkine receptor .
23132925	0	LDL_receptor-related_protein-1	0,30	myelin-associated_glycoprotein	73,103	LDL receptor-related protein-1	myelin-associated glycoprotein	4035	4099	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	LDL_receptor-related_protein-1 is a sialic-acid-independent receptor for myelin-associated_glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin .
21711236	0	LDL_receptor-related_protein-1	47,77	uPAR	38,42	LDL receptor-related protein-1	uPAR	4035	5329	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the urokinase receptor -LRB- uPAR -RRB- by LDL_receptor-related_protein-1 -LRB- LRP1 -RRB- .
12579474	0	LDL_receptor-related_protein_5	36,66	LRP5	68,72	LDL receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Six novel missense mutations in the LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- gene in different conditions with an increased bone density .
14735475	0	LDL_receptor-related_protein_5	14,44	LRP5	46,50	LDL receptor-related protein 5	LRP5	4041	4041	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- as a novel marker for disease progression in high-grade osteosarcoma .
15824851	0	LDL_receptor-related_protein_5	30,60	LRP5	62,66	LDL receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Heterozygous mutations in the LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with primary_osteoporosis in children .
24014470	0	LDL_receptor-related_protein_5	67,97	LRP5	99,103	LDL receptor-related protein 5	LRP5	4041	4041	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Pregnancy-associated_osteoporosis with a heterozygous deactivating LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- mutation and a homozygous methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism .
14978770	0	LDLr	74,78	low_density_lipoprotein_receptor	40,72	LDLr	low density lipoprotein receptor	16835(Tax:10090)	16835(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Non-physiological overexpression of the low_density_lipoprotein_receptor -LRB- LDLr -RRB- gene in the liver induces pathological intracellular lipid and cholesterol storage .
16272576	0	LDOC1	43,48	WAVE3	0,5	LDOC1	WAVE3	23641	10810	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	WAVE3 functions as a negative regulator of LDOC1 .
11973282	0	LEAFY	15,20	FLOWER1	43,50	LEAFY	FLOWER1	836307(Tax:3702)	829845(Tax:3702)	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction of LEAFY , AGAMOUS and TERMINAL FLOWER1 in maintaining floral meristem identity in Arabidopsis .
21750030	0	LEAFY	43,48	LATE_MERISTEM_IDENTITY2	0,23	LEAFY	LATE MERISTEM IDENTITY2	836307(Tax:3702)	825297(Tax:3702)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	LATE_MERISTEM_IDENTITY2 acts together with LEAFY to activate APETALA1 .
26537561	0	LEAFY	53,58	PLETHORA3	36,45	LEAFY	PLETHORA3	836307(Tax:3702)	830915(Tax:3702)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	AINTEGUMENTA and AINTEGUMENTA-LIKE6 / PLETHORA3 induce LEAFY expression in response to auxin to promote the onset of flower formation in Arabidopsis .
15516508	0	LEAFY_COTYLEDON2	110,126	AtGA3ox2	0,8	LEAFY COTYLEDON2	AtGA3ox2	839724(Tax:3702)	844374(Tax:3702)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	AtGA3ox2 , a key gene responsible for bioactive gibberellin biosynthesis , is regulated during embryogenesis by LEAFY_COTYLEDON2 and FUSCA3 in Arabidopsis .
16339853	0	LEAFY_PETIOLE	57,70	AP2	31,34	LEAFY PETIOLE	AP2	831238(Tax:3702)	829845(Tax:3702)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	A new role for the Arabidopsis AP2 transcription factor , LEAFY_PETIOLE , in gibberellin-induced germination is revealed by the misexpression of a homologous gene , SOB2/DRN-LIKE .
15350756	0	LEAP-2	88,94	liver-expressed_antimicrobial_peptide_2	47,86	LEAP-2	liver-expressed antimicrobial peptide 2	100136189(Tax:8022)	100136189(Tax:8022)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Discovery and characterization of two types of liver-expressed_antimicrobial_peptide_2 -LRB- LEAP-2 -RRB- genes in rainbow_trout .
7690324	0	LECAM-1	24,31	L-selectin	33,43	LECAM-1	L-selectin	29259(Tax:10116)	29259(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of rat LECAM-1 -LRB- L-selectin -RRB- by the use of monoclonal antibodies and evidence for the presence of soluble LECAM-1 in rat sera .
12200076	0	LECAM-1	48,55	Leukocyte-endothelial_cell_adhesion_molecule_1	0,46	LECAM-1	Leukocyte-endothelial cell adhesion molecule 1	6402	6402	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Leukocyte-endothelial_cell_adhesion_molecule_1 -LRB- LECAM-1 -RRB- polymorphism is associated with diabetic_nephropathy in type_2_diabetes_mellitus .
24076354	0	LECT2	83,88	leukocyte_cell-derived_chemotaxin-2	46,81	LECT2	leukocyte cell-derived chemotaxin-2	101797061	101797061	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and expression analysis of the leukocyte_cell-derived_chemotaxin-2 -LRB- LECT2 -RRB- gene in duck -LRB- Anas_platyrhynchos -RRB- .
24390366	0	LECT2	53,58	leukocyte_cell-derived_chemotaxin_2	16,51	LECT2	leukocyte cell-derived chemotaxin 2	3950	3950	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increased serum leukocyte_cell-derived_chemotaxin_2 -LRB- LECT2 -RRB- levels in obesity_and_fatty_liver .
19864417	0	LEDGF	29,34	Cdc7-activator_of_S-phase_kinase	50,82	LEDGF	Cdc7-activator of S-phase kinase	11168	10926	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transcriptional co-activator LEDGF interacts with Cdc7-activator_of_S-phase_kinase -LRB- ASK -RRB- and stimulates its enzymatic activity .
12697420	0	LEDGF	0,5	PKC_gamma_and_gap	20,37	LEDGF	PKC gamma and gap	11168	5582	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	LEDGF activation of PKC_gamma_and_gap junction disassembly in lens epithelial cells .
23386123	0	LEDGF	25,30	SUV39H1	69,76	LEDGF	SUV39H1	11168	6839	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island .
18343576	0	LEDGF	0,5	alphaB-crystallin	51,68	LEDGF	alphaB-crystallin	313323(Tax:10116)	25420(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	LEDGF binding to stress response element increases alphaB-crystallin expression in astrocytes with oxidative stress .
24604027	0	LEDGF	102,107	lens_epithelial-derived_growth_factor	63,100	LEDGF	lens epithelial-derived growth factor	11168	11168	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Oncogenic human papillomaviruses activate the tumor-associated lens_epithelial-derived_growth_factor -LRB- LEDGF -RRB- gene .
25590759	0	LEDGF/p75	23,32	Iws1	49,53	LEDGF/p75	Iws1	11168	55677	Gene	Gene	Associates|compound|START_ENTITY Associates|nmod|END_ENTITY	The Integrase Cofactor LEDGF/p75 Associates with Iws1 and Spt6 for Postintegration Silencing of HIV-1 Gene Expression in Latently Infected Cells .
22275515	0	LEDGF/p75	23,32	MeCP2	79,84	LEDGF/p75	MeCP2	11168	4204	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The stress oncoprotein LEDGF/p75 interacts with the methyl_CpG binding protein MeCP2 and influences its transcriptional activity .
11696550	0	LEF-1	16,21	Alx4	0,4	LEF-1	Alx4	16842(Tax:10090)	11695(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|advmod|END_ENTITY	Alx4 binding to LEF-1 regulates N-CAM promoter activity .
10428961	0	LEF-1	92,97	Axin	0,4	LEF-1	Axin	51176	8312	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Axin and Frat1 interact with dvl and GSK , bridging Dvl to GSK in Wnt-mediated regulation of LEF-1 .
17090604	0	LEF-1	52,57	Beta-catenin	0,12	LEF-1	Beta-catenin	51176	1499	Gene	Gene	suppression|nmod|START_ENTITY relieves|dobj|suppression relieves|nsubj|END_ENTITY	Beta-catenin relieves I-mfa-mediated suppression of LEF-1 in mammalian cells .
17980157	0	LEF-1	0,5	E2F1	37,41	LEF-1	E2F1	51176	1869	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	LEF-1 activates the transcription of E2F1 .
25178368	0	LEF-1	74,79	Lymphoid_Enhancer_Binding_Factor_1	38,72	LEF-1	Lymphoid Enhancer Binding Factor 1	100170126(Tax:9823)	100170126(Tax:9823)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of Novel Polymorphisms in Lymphoid_Enhancer_Binding_Factor_1 -LRB- LEF-1 -RRB- Gene with Number of Teats in Different Breeds of Pig .
12032083	0	LEF-1	62,67	Microphthalmia-associated_transcription_factor	0,46	LEF-1	Microphthalmia-associated transcription factor	51176	4286	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Microphthalmia-associated_transcription_factor interacts with LEF-1 , a mediator of Wnt signaling .
20525792	0	LEF-1	50,55	YY1	11,14	LEF-1	YY1	51176	7528	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A role for YY1 in repression of dominant negative LEF-1 expression in colon_cancer .
10330485	0	LEF-1	103,108	beta-catenin	109,121	LEF-1	beta-catenin	779101(Tax:8355)	399274(Tax:8355)	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1 / beta-catenin complex in Xenopus_laevis .
10330485	0	LEF-1	103,108	beta-catenin	41,53	LEF-1	beta-catenin	779101(Tax:8355)	399274(Tax:8355)	Gene	Gene	complex|compound|START_ENTITY signaling|nmod|complex necessary|advcl|signaling necessary|nsubj|domain domain|nmod|END_ENTITY	The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1 / beta-catenin complex in Xenopus_laevis .
10966653	0	LEF-1	48,53	beta-catenin	13,25	LEF-1	beta-catenin	51176	1499	Gene	Gene	interactions|nmod|START_ENTITY spots|nmod|interactions spots|nmod|END_ENTITY	Hot spots in beta-catenin for interactions with LEF-1 , conductin and APC .
11029052	0	LEF-1	98,103	beta-catenin	18,30	LEF-1	beta-catenin	51176	1499	Gene	Gene	function|nmod|START_ENTITY independent|nmod|function induces|xcomp|independent induces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators .
11913959	0	LEF-1	63,68	beta-catenin	124,136	LEF-1	beta-catenin	16842(Tax:10090)	12387(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|advcl|END_ENTITY	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
11913959	0	LEF-1	63,68	beta-catenin	47,59	LEF-1	beta-catenin	16842(Tax:10090)	12387(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|import import|nmod|END_ENTITY	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
11913959	0	LEF-1	86,91	beta-catenin	124,136	LEF-1	beta-catenin	16842(Tax:10090)	12387(Tax:10090)	Gene	Gene	import|compound|START_ENTITY END_ENTITY|dep|import	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
11913959	0	LEF-1	86,91	beta-catenin	47,59	LEF-1	beta-catenin	16842(Tax:10090)	12387(Tax:10090)	Gene	Gene	import|compound|START_ENTITY beta-catenin|dep|import dependent|advcl|beta-catenin dependent|nsubj|import import|nmod|END_ENTITY	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
12052822	0	LEF-1	61,66	beta-catenin	7,19	LEF-1	beta-catenin	51176	1499	Gene	Gene	promoter|compound|START_ENTITY induces|nmod|promoter induces|nsubj|signaling signaling|amod|END_ENTITY	Wnt-3A / beta-catenin signaling induces transcription from the LEF-1 promoter .
16378739	0	LEF-1	14,19	beta-catenin	80,92	LEF-1	beta-catenin	51176	1499	Gene	Gene	proteins|compound|START_ENTITY display|nsubj|proteins display|dobj|patterns patterns|nmod|END_ENTITY	Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells .
8757136	0	LEF-1	69,74	beta-catenin	26,38	LEF-1	beta-catenin	51176	31151(Tax:7227)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of beta-catenin with the transcription factor LEF-1 .
8892228	0	LEF-1	78,83	beta-catenin	24,36	LEF-1	beta-catenin	16842(Tax:10090)	12387(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of beta-catenin by interaction with transcription factor LEF-1 .
9671490	0	LEF-1	44,49	beta-catenin	102,114	LEF-1	beta-catenin	16842(Tax:10090)	12387(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY Modulation|nmod|regulation Modulation|nmod|END_ENTITY	Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin .
18579517	0	LEF-1	0,5	interleukin-4	26,39	LEF-1	interleukin-4	51176	3565	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element .
19861271	0	LEF-1	115,120	lymphoid_enhancer-binding_factor_1	79,113	LEF-1	lymphoid enhancer-binding factor 1	51176	51176	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Functional study of the eukaryotic fluorescent expression vector of truncated lymphoid_enhancer-binding_factor_1 -LRB- LEF-1 -RRB- gene in SW480 cells -RSB- .
22157808	0	LEF1	113,117	CYLD	100,104	LEF1	CYLD	51176	1540	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Dysregulation of TNFa-induced necroptotic signaling in chronic_lymphocytic_leukemia : suppression of CYLD gene by LEF1 .
24658583	0	LEF1	54,58	Lymphoid_Enhancer-Binding_Factor_1	18,52	LEF1	Lymphoid Enhancer-Binding Factor 1	51176	51176	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Lymphoid_Enhancer-Binding_Factor_1 -LRB- LEF1 -RRB- in solid-pseudopapillary_neoplasms of the pancreas .
23677615	0	LEF1	113,117	SLUG	129,133	LEF1	SLUG	51176	6591	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 -LRB- SLUG -RRB- .
22261717	0	LEF1/TCF	51,59	IGF1R	8,13	LEF1/TCF	IGF1R	51176;3172	3480	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF .
11943586	0	LEKTI	0,5	proteinase	28,38	LEKTI	proteinase	11005	100616101	Gene	Gene	START_ENTITY|dep|inhibitor inhibitor|compound|END_ENTITY	LEKTI : a multidomain serine proteinase inhibitor with pathophysiological relevance .
20069636	0	LEKTI	38,43	proteinase	17,27	LEKTI	proteinase	11005	100616101	Gene	Gene	START_ENTITY|nsubj|Synthesis Synthesis|nmod|inhibitor inhibitor|amod|END_ENTITY	Synthesis of the proteinase inhibitor LEKTI domain 6 by the fragment condensation method and regioselective disulfide bond formation .
21997416	0	LEKTI	36,41	proteinase	86,96	LEKTI	proteinase	11005	100616101	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	When activity requires breaking up : LEKTI proteolytic activation cascade for specific proteinase inhibition .
17387579	0	LELP1	108,113	late_cornified_envelope-like_proline-rich_1	63,106	LELP1	late cornified envelope-like proline-rich 1	149018	149018	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a chromosome 1q21 locus in close proximity to a late_cornified_envelope-like_proline-rich_1 -LRB- LELP1 -RRB- gene with total serum IgE levels .
24686170	0	LEO1	0,4	PRL-3	21,26	LEO1	PRL-3	123169	11156	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute_myelogenous_leukemia .
22290286	0	LEP	75,78	H-FABP	80,86	LEP	H-FABP	396832(Tax:9823)	399532(Tax:9823)	Gene	Gene	START_ENTITY|appos|genes genes|amod|END_ENTITY	Distribution and linkage disequilibrium analysis of polymorphisms of MC4R , LEP , H-FABP genes in the different populations of pigs , associated with economic traits in DIV2 line .
11531701	0	LEP	34,37	leptin	26,32	LEP	leptin	396832(Tax:9823)	396832(Tax:9823)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of swine leptin -LRB- LEP -RRB- polymorphisms and their association with production traits .
16261186	0	LEP	54,57	leptin	41,47	LEP	leptin	3952	3952	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Microsatellite polymorphism of the human leptin gene -LRB- LEP -RRB- and risk of cardiovascular_disease .
23544120	0	LEP	87,90	leptin	79,85	LEP	leptin	16846(Tax:10090)	16846(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Chito-oligosaccharide inhibits the de-methylation of a ` CpG ' island within the leptin -LRB- LEP -RRB- promoter during adipogenesis of 3T3-L1 cells .
24823393	0	LEP	48,51	leptin	32,38	LEP	leptin	3952	3952	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Discovery of a novel functional leptin protein -LRB- LEP -RRB- in zebra_finches : evidence for the existence of an authentic avian leptin gene predominantly expressed in the brain and pituitary .
27075752	0	LEP	33,36	leptin	25,31	LEP	leptin	3952	3952	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The p. _ N103K mutation of leptin -LRB- LEP -RRB- gene and severe early onset obesity in Pakistan .
25383655	0	LEPR	43,47	Leptin_Receptor_Gene	21,41	LEPR	Leptin Receptor Gene	3953	3953	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Serum Leptin Levels , Leptin_Receptor_Gene -LRB- LEPR -RRB- Polymorphism , and the Risk of Systemic_Lupus_Erythematosus in Kashmiri Population .
22028824	0	LEPR	58,62	leptin_receptor	36,51	LEPR	leptin receptor	3953	3953	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between variants of the leptin_receptor gene -LRB- LEPR -RRB- and overweight : a systematic review and an analysis of the CoLaus study .
23090836	0	LEPR	25,29	leptin_receptor	8,23	LEPR	leptin receptor	3953	3953	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Role of leptin_receptor -LRB- LEPR -RRB- gene polymorphisms and haplotypes in susceptibility to hepatocellular_carcinoma in subjects with chronic hepatitis_B_virus infection .
11342119	0	LEPROTL1	98,106	leptin_receptor_overlapping_transcript-like_1	46,91	LEPROTL1	leptin receptor overlapping transcript-like 1	23484	23484	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a novel human leptin_receptor_overlapping_transcript-like_1 gene -LRB- LEPROTL1 -RRB- .
23815345	0	LET-418	27,34	Mi2	35,38	LET-418	Mi2	178970(Tax:6239)	40170(Tax:7227)	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	The Caenorhabditis_elegans LET-418 / Mi2 plays a conserved role in lifespan regulation .
26188247	0	LET-502	75,82	RHGF-2	32,38	LET-502	RHGF-2	172088(Tax:6239)	173748(Tax:6239)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. _ elegans .
26188247	0	LET-502	75,82	RHGF-2	32,38	LET-502	RHGF-2	172088(Tax:6239)	173748(Tax:6239)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. _ elegans .
9671465	0	LET-60	82,88	SUR-5	23,28	LET-60	SUR-5	178104(Tax:6239)	180992(Tax:6239)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Caenorhabditis_elegans SUR-5 , a novel but conserved protein , negatively regulates LET-60 Ras activity during vulval induction .
1522074	0	LEU2	157,161	3-isopropylmalate_dehydrogenase	119,150	LEU2	3-isopropylmalate dehydrogenase	850342(Tax:4932)	850342(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Directed mutagenesis in an asporogenous methylotrophic yeast : cloning , sequencing , and one-step gene disruption of the 3-isopropylmalate_dehydrogenase gene -LRB- LEU2 -RRB- of Candida boidinii to derive doubly auxotrophic marker strains .
7743940	0	LEUNIG	0,6	AGAMOUS	17,24	LEUNIG	AGAMOUS	829390(Tax:3702)	827631(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	LEUNIG regulates AGAMOUS expression in Arabidopsis flowers .
11782418	0	LEUNIG	111,117	SEUSS	0,5	LEUNIG	SEUSS	829390(Tax:3702)	840981(Tax:3702)	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	SEUSS , a member of a novel family of plant regulatory proteins , represses floral homeotic gene expression with LEUNIG .
24446090	0	LEUTX	29,34	leucine_twenty_homeobox	4,27	LEUTX	leucine twenty homeobox	342900	342900	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The leucine_twenty_homeobox -LRB- LEUTX -RRB- gene , which lacks a histone acetyltransferase domain , is fused to KAT6A in therapy-related acute_myeloid_leukemia with t -LRB- 8 ; 19 -RRB- -LRB- p11 ; q13 -RRB- .
12064793	0	LFA-1	24,29	CD11a	17,22	LFA-1	CD11a	3683	3683	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Up-regulation of CD11a -LRB- LFA-1 -RRB- expression on peripheral CD4 + T cells in primary_biliary_cirrhosis .
9420139	0	LFA-1	49,54	CD23	132,136	LFA-1	CD23	3683	2208	Gene	Gene	induction|nmod|START_ENTITY interleukin-7|nmod|induction molecules|amod|interleukin-7 role|nmod|molecules role|nmod|subset subset|compound|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
11399626	0	LFA-1	14,19	CD34	34,38	LFA-1	CD34	3683	947	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Regulation of LFA-1 Expression by CD34 Positive Cells and Inducible Growth Factor Production by Stroma Enable Formation of Bone Marrow Compartments ; Subject Heading .
12847234	0	LFA-1	28,33	CD34	111,115	LFA-1	CD34	3683	947	Gene	Gene	induction|nmod|START_ENTITY step|nsubj|induction step|acl|required required|nmod|Lin Lin|compound|END_ENTITY	IL-15-mediated induction of LFA-1 is a late step required for cytotoxic differentiation of human NK cells from CD34 + Lin - bone marrow cells .
1378320	0	LFA-1	130,135	CD34	124,128	LFA-1	CD34	3683	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
1378320	0	LFA-1	130,135	CD34	81,85	LFA-1	CD34	3683	947	Gene	Gene	cells|compound|START_ENTITY primitive|nmod|cells primitive|nsubj|Expression Expression|nmod|molecules molecules|nmod|cells cells|dep|LFA-1 LFA-1|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
1378320	0	LFA-1	87,92	CD34	124,128	LFA-1	CD34	3683	947	Gene	Gene	cells|dep|START_ENTITY molecules|nmod|cells Expression|nmod|molecules primitive|nsubj|Expression primitive|nmod|cells cells|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
8639769	0	LFA-1	13,18	CD34	34,38	LFA-1	CD34	3683	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Induction of LFA-1 on pluripotent CD34 + bone marrow cells does not affect lineage commitment .
11412874	0	LFA-1	0,5	CD4	20,23	LFA-1	CD4	3683	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|CD45RO CD45RO|compound|END_ENTITY	LFA-1 expression on CD4 -LRB- + -RRB- CD45RO -LRB- + -RRB- peripheral blood T-lymphocytes in RR MS : effects induced by rIFNbeta-1a .
12064793	0	LFA-1	24,29	CD4	56,59	LFA-1	CD4	3683	920	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Up-regulation of CD11a -LRB- LFA-1 -RRB- expression on peripheral CD4 + T cells in primary_biliary_cirrhosis .
1347547	1	LFA-1	158,163	CD4	88,91	LFA-1	CD4	3683	920	Gene	Gene	pathway|compound|START_ENTITY mediated|nmod|pathway signal|acl|mediated require|dobj|signal require|nsubj|cells cells|compound|END_ENTITY	Naive CD4 +45 RA + T cells require a costimulatory signal mediated through the LFA-1 / ICAM-1 pathway .
1350461	0	LFA-1	26,31	CD4	115,118	LFA-1	CD4	16414(Tax:10090)	12504(Tax:10090)	Gene	Gene	molecules|amod|START_ENTITY CD3|nmod|molecules Co-engagement|nmod|CD3 enhances|nsubj|Co-engagement enhances|dobj|frequency frequency|nmod|activation activation|nmod|+ +|compound|END_ENTITY	Co-engagement of CD3 with LFA-1 or ICAM-1 adhesion molecules enhances the frequency of activation of single murine CD4 + and CD8 + T cells and induces synthesis of IL-3 and IFN-gamma but not IL-4 or IL-6 .
15383575	0	LFA-1	0,5	CD4	9,12	LFA-1	CD4	16408(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	LFA-1 on CD4 + T cells is required for optimal antigen-dependent activation in vivo .
15544853	0	LFA-1	28,33	CD4	78,81	LFA-1	CD4	3683	920	Gene	Gene	activation|compound|START_ENTITY down-regulates|dobj|activation down-regulates|advcl|modulating modulating|nmod|+ +|compound|END_ENTITY	Somatostatin down-regulates LFA-1 activation by modulating Rap1 expression in CD4 + and CD8 + T cells .
16002691	0	LFA-1	14,19	CD4	144,147	LFA-1	CD4	3683	920	Gene	Gene	activity|compound|START_ENTITY remodeling|nsubj|activity Regulation|acl|remodeling modulates|nsubj|Regulation modulates|dobj|efficiency efficiency|nmod|entry entry|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Regulation of LFA-1 activity through cytoskeleton remodeling and signaling components modulates the efficiency of HIV_type-1 entry in activated CD4 + T lymphocytes .
1671082	0	LFA-1	92,97	CD4	48,51	LFA-1	CD4	3683	920	Gene	Gene	deficient|nmod|START_ENTITY lymphocytes|xcomp|deficient lymphocytes|nsubj|infection infection|nmod|T T|compound|END_ENTITY	Human_immunodeficiency_virus _ -LRB- HIV -RRB- _ infection in CD4 + T lymphocytes genetically deficient in LFA-1 : LFA-1 is required for HIV-mediated cell fusion but not for viral transmission .
1671082	0	LFA-1	99,104	CD4	48,51	LFA-1	CD4	3683	920	Gene	Gene	required|nsubjpass|START_ENTITY _|parataxis|required _|ccomp|lymphocytes lymphocytes|nsubj|infection infection|nmod|T T|compound|END_ENTITY	Human_immunodeficiency_virus _ -LRB- HIV -RRB- _ infection in CD4 + T lymphocytes genetically deficient in LFA-1 : LFA-1 is required for HIV-mediated cell fusion but not for viral transmission .
1706184	0	LFA-1	12,17	CD4	66,69	LFA-1	CD4	3683	920	Gene	Gene	epitopes|appos|START_ENTITY involved|nsubj|epitopes involved|nmod|T-cells T-cells|compound|END_ENTITY	CD11a/CD18 -LRB- LFA-1 -RRB- epitopes involved in syncytium formation among CD4 + T-cells following cell free HIV-1_infection .
19235605	0	LFA-1	45,50	CD4	54,57	LFA-1	CD4	3683	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	The effect of rhG-CSF on the conformation of LFA-1 on CD4 + T cells in hemopoietic stem cell transplantation .
21850260	0	LFA-1	29,34	CD4	38,41	LFA-1	CD4	3683	920	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin -LRB- LtxA -RRB- .
26740009	0	LFA-1	87,92	CD4	16,19	LFA-1	CD4	16414(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-cell|nmod|START_ENTITY T-cell|nsubj|END_ENTITY	PI3K promotes CD4 -LRB- + -RRB- T-cell interactions with antigen-presenting_cells by increasing LFA-1 binding to ICAM-1 .
7522975	0	LFA-1	8,13	CD4	62,65	LFA-1	CD4	3683	920	Gene	Gene	Role|nmod|START_ENTITY surface|nsubj|Role surface|dobj|receptors receptors|nmod|adhesion adhesion|compound|END_ENTITY	Role of LFA-1 , CD2 , VLA-5 / CD29 , and CD43 surface receptors in CD4 + T cell adhesion to B cells .
7911073	0	LFA-1	34,39	CD4	0,3	LFA-1	CD4	16408(Tax:10090)	12504(Tax:10090)	Gene	Gene	ICAM-1|compound|START_ENTITY adhesion|nmod|ICAM-1 require|dobj|adhesion require|nsubj|cells cells|compound|END_ENTITY	CD4 + T cells require adhesion via LFA-1 / ICAM-1 to induce target apoptosis in TNF-independent pathway .
8547030	0	LFA-1	11,16	CD4	99,102	LFA-1	CD4	3683	920	Gene	Gene	interaction|compound|START_ENTITY critical|nsubj|interaction critical|nmod|cells cells|compound|END_ENTITY	The ICAM-3 / LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4 + T cells .
9420139	0	LFA-1	49,54	CD4	127,130	LFA-1	CD4	3683	920	Gene	Gene	induction|nmod|START_ENTITY interleukin-7|nmod|induction molecules|amod|interleukin-7 role|nmod|molecules role|nmod|subset subset|compound|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
9837689	0	LFA-1	12,17	CD4	65,68	LFA-1	CD4	308995(Tax:10116)	24932(Tax:10116)	Gene	Gene	Decrease|nmod|START_ENTITY associated|nsubjpass|Decrease associated|nmod|T T|compound|END_ENTITY	Decrease of LFA-1 is associated with upregulation of TGF-beta in CD4 -LRB- + -RRB- T cell clones derived from rats nasally tolerized against experimental autoimmune_myasthenia_gravis .
12193230	0	LFA-1	94,99	CD44	101,105	LFA-1	CD44	16414(Tax:10090)	12505(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY VCAM-1|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
19483086	0	LFA-1	0,5	CD8	16,19	LFA-1	CD8	3689	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	LFA-1 regulates CD8 + T cell activation via T_cell_receptor-mediated and LFA-1-mediated Erk1/2 signal pathways .
9278313	0	LFA-1	26,31	CD99	0,4	LFA-1	CD99	3683	4267	Gene	Gene	adhesion|compound|START_ENTITY regulates|dobj|adhesion regulates|nsubj|END_ENTITY	CD99 -LRB- MIC2 -RRB- regulates the LFA-1 / ICAM-1-mediated adhesion of lymphocytes , and its gene encodes both positive and negative regulators of cellular adhesion .
24346075	0	LFA-1	20,25	Galectin-8	0,10	LFA-1	Galectin-8	3683	3964	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Galectin-8 binds to LFA-1 , blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients .
18274961	0	LFA-1	103,108	ICAM	109,113	LFA-1	ICAM	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	Preclinical absorption , distribution , metabolism and excretion -LRB- ADME -RRB- characterization of ICAM1988 , an LFA-1 / ICAM antagonist , and its prodrug .
10195438	0	LFA-1	64,69	ICAM-1	84,90	LFA-1	ICAM-1	3683	3383	Gene	Gene	alpha-subunit|nmod|START_ENTITY derived|nmod|alpha-subunit peptide|acl|derived peptide|dep|inhibitor inhibitor|nmod|adhesion adhesion|compound|END_ENTITY	A Ca2 + binding cyclic peptide derived from the alpha-subunit of LFA-1 : inhibitor of ICAM-1 / LFA-1-mediated T-cell adhesion .
10233694	0	LFA-1	94,99	ICAM-1	100,106	LFA-1	ICAM-1	3683	3383	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA-1 / ICAM-1 pathway .
10375080	0	LFA-1	116,121	ICAM-1	109,115	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	VLA-4|dep|START_ENTITY VLA-4|compound|END_ENTITY	Differential Th1 and Th2 cell regulation of murine cardiac allograft acceptance by blocking cell adhesion of ICAM-1 / LFA-1 and VCAM-1 / VLA-4 .
10556544	0	LFA-1	56,61	ICAM-1	49,55	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	interactions|compound|START_ENTITY using|nsubj|interactions Development|parataxis|using Development|nmod|assay assay|nmod|END_ENTITY	Development of a cell-free binding assay for rat ICAM-1 / LFA-1 interactions using a novel anti-rat LFA-1 monoclonal antibody and comparison with a cell-based assay .
10556544	0	LFA-1	98,103	ICAM-1	49,55	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	antibody|compound|START_ENTITY using|dobj|antibody Development|parataxis|using Development|nmod|assay assay|nmod|END_ENTITY	Development of a cell-free binding assay for rat ICAM-1 / LFA-1 interactions using a novel anti-rat LFA-1 monoclonal antibody and comparison with a cell-based assay .
10835320	0	LFA-1	17,22	ICAM-1	10,16	LFA-1	ICAM-1	3683	3383	Gene	Gene	mediates|compound|START_ENTITY altered|nsubj|mediates END_ENTITY|parataxis|altered	Intrinsic ICAM-1 / LFA-1 activation mediates altered responsiveness of atopic asthmatic airway_smooth_muscle .
10836363	0	LFA-1	91,96	ICAM-1	97,103	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|parataxis|END_ENTITY	Induction of unresponsiveness to islet xenograft by MMC treatment of graft and blockage of LFA-1 / ICAM-1 pathway .
10861083	0	LFA-1	4,9	ICAM-1	49,55	LFA-1	ICAM-1	3689	3383	Gene	Gene	integrin|compound|START_ENTITY supports|nsubj|integrin supports|dobj|adhesions adhesions|nmod|END_ENTITY	The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment .
10998349	0	LFA-1	147,152	ICAM-1	56,62	LFA-1	ICAM-1	3683	3383	Gene	Gene	site|appos|START_ENTITY integrity|nmod|site maintains|dobj|integrity maintains|nsubj|domain domain|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	The second domain of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- maintains the structural integrity of the leucocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- ligand-binding site in the first domain .
11327603	0	LFA-1	52,57	ICAM-1	58,64	LFA-1	ICAM-1	3683	3383	Gene	Gene	Discovery|nmod|START_ENTITY /|nsubj|Discovery /|dobj|antagonists antagonists|compound|END_ENTITY	Discovery and SAR of diarylsulfide_cyclopropylamide LFA-1 / ICAM-1 interaction antagonists .
11590197	0	LFA-1	79,84	ICAM-1	72,78	LFA-1	ICAM-1	3683	3383	Gene	Gene	VLA-4|dep|START_ENTITY VLA-4|compound|END_ENTITY	Differential regulation of transendothelial migration of THP-1 cells by ICAM-1 / LFA-1 and VCAM-1 / VLA-4 .
11786177	0	LFA-1	69,74	ICAM-1	75,81	LFA-1	ICAM-1	3683	3383	Gene	Gene	activity|nmod|START_ENTITY activity|parataxis|interaction interaction|nsubj|END_ENTITY	Synergistic inhibitory activity of alpha - and beta-LFA-1 peptides on LFA-1 / ICAM-1 interaction .
11800139	0	LFA-1	8,13	ICAM-1	14,20	LFA-1	ICAM-1	3683	3383	Gene	Gene	VCAM-1|compound|START_ENTITY VCAM-1|dep|END_ENTITY	Role of LFA-1 / ICAM-1 , CLA/E-selectin and VLA-4 / VCAM-1 pathways in recruiting leukocytes to the various regions of the chronic leg ulcer .
11834174	0	LFA-1	22,27	ICAM-1	15,21	LFA-1	ICAM-1	3683	3383	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of ICAM-1 / LFA-1 in the pocket area of adult_periodontitis -RSB- .
11834839	0	LFA-1	17,22	ICAM-1	57,63	LFA-1	ICAM-1	3683	3383	Gene	Gene	antagonist|compound|START_ENTITY antagonist|nmod|transfer transfer|nmod|immunoregulatory immunoregulatory|compound|END_ENTITY	Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule .
11882913	0	LFA-1	25,30	ICAM-1	18,24	LFA-1	ICAM-1	3683	3383	Gene	Gene	interaction|compound|START_ENTITY role|dep|interaction role|nmod|END_ENTITY	Essential role of ICAM-1 / LFA-1 interaction in synergistic effect of IL-18 and IL-12 on IFN-gamma production in human PBMC .
11922836	0	LFA-1	82,87	ICAM-1	105,111	LFA-1	ICAM-1	3683	3383	Gene	Gene	I-domain|nmod|START_ENTITY peptide|nmod|I-domain properties|nmod|peptide properties|dep|inhibitor inhibitor|nmod|END_ENTITY	Structural and ICAM-1-docking properties of a cyclic peptide from the I-domain of LFA-1 : an inhibitor of ICAM-1 / LFA - _ 1-mediated T-cell adhesion .
11929876	0	LFA-1	22,27	ICAM-1	99,105	LFA-1	ICAM-1	3689	3383	Gene	Gene	activation|compound|START_ENTITY regulation|nmod|activation regulation|appos|END_ENTITY	Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in shear flow .
12454403	0	LFA-1	23,28	ICAM-1	29,35	LFA-1	ICAM-1	3683	3383	Gene	Gene	studies|nmod|START_ENTITY studies|dep|interaction interaction|compound|END_ENTITY	Comparative studies of LFA-1 / ICAM-1 interaction by micropipette and flow chamber techniques .
12643766	0	LFA-1	23,28	ICAM-1	85,91	LFA-1	ICAM-1	3683	3383	Gene	Gene	protein|compound|START_ENTITY protein|acl:relcl|modulates modulates|nmod|protein protein|compound|END_ENTITY	A peptide derived from LFA-1 protein that modulates T-cell adhesion binds to soluble ICAM-1 protein .
12659746	0	LFA-1	78,83	ICAM-1	71,77	LFA-1	ICAM-1	3683	3383	Gene	Gene	study|parataxis|START_ENTITY study|nmod|END_ENTITY	QSAR study on some p-arylthio_cinnamides as antagonists of biochemical ICAM-1 / LFA-1 interaction and ICAM-1 / JY-8 cell adhesion in relation to anti-inflammatory activity .
12732350	0	LFA-1	17,22	ICAM-1	10,16	LFA-1	ICAM-1	3683	3383	Gene	Gene	interaction|compound|START_ENTITY interaction|dep|Targeting Targeting|dobj|END_ENTITY	Targeting ICAM-1 / LFA-1 interaction for controlling autoimmune_diseases : designing peptide and small molecule inhibitors .
1346257	0	LFA-1	80,85	ICAM-1	49,55	LFA-1	ICAM-1	3683	15894(Tax:10090)	Gene	Gene	distinct|nmod|START_ENTITY site|amod|distinct erythrocytes|nmod|site erythrocytes|dobj|END_ENTITY	Plasmodium_falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1 , Mac-1 , and human rhinovirus .
1347547	1	LFA-1	158,163	ICAM-1	164,170	LFA-1	ICAM-1	3683	3383	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Naive CD4 +45 RA + T cells require a costimulatory signal mediated through the LFA-1 / ICAM-1 pathway .
1348286	0	LFA-1	43,48	ICAM-1	24,30	LFA-1	ICAM-1	3683	3383	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	Expression of the CD54 -LRB- ICAM-1 -RRB- and CD11a -LRB- LFA-1 -RRB- adhesion molecules in oral mucosal_inflammation .
1355751	0	LFA-1	88,93	ICAM-1	35,41	LFA-1	ICAM-1	3683	3383	Gene	Gene	expression|appos|START_ENTITY function-associated|dobj|expression function-associated|nsubj|Intercellular_adhesion_molecule-1 Intercellular_adhesion_molecule-1|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and leukocyte function-associated antigen-1 -LRB- LFA-1 -RRB- expression in human epiretinal membranes .
1358901	0	LFA-1	26,31	ICAM-1	32,38	LFA-1	ICAM-1	3683	3383	Gene	Gene	contribution|nmod|START_ENTITY contribution|dep|complex complex|compound|END_ENTITY	Force contribution of the LFA-1 / ICAM-1 complex to T cell adhesion .
14616784	0	LFA-1	92,97	ICAM-1	98,104	LFA-1	ICAM-1	3683	3383	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Transendothelial migration confers a survival advantage to activated T lymphocytes : role of LFA-1 / ICAM-1 interactions .
15058041	0	LFA-1	11,16	ICAM-1	70,76	LFA-1	ICAM-1	3683	3383	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	-LSB- Effect of LFA-1 expression on neutrophils and serum level of soluble ICAM-1 in patients with chronic_myelogenous_leukemia -RSB- .
15109637	0	LFA-1	66,71	ICAM-1	72,78	LFA-1	ICAM-1	3683	3383	Gene	Gene	inhibitors|nmod|START_ENTITY 1,3-oxazinan-2-ones|nmod|inhibitors interaction|dep|1,3-oxazinan-2-ones interaction|compound|END_ENTITY	Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1 / ICAM-1 interaction : stabilization of the metabolically labile vanillyl side chain .
15142527	0	LFA-1	0,5	ICAM-1	6,12	LFA-1	ICAM-1	3683	3383	Gene	Gene	START_ENTITY|appos|lowers lowers|nsubj|interaction interaction|compound|END_ENTITY	LFA-1 / ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation .
15363150	0	LFA-1	19,24	ICAM-1	25,31	LFA-1	ICAM-1	3683	3383	Gene	Gene	advance|nmod|START_ENTITY advance|dep|signal signal|compound|END_ENTITY	-LSB- Recent advance on LFA-1 / ICAM-1 costimulatory signal of T cell-review -RSB- .
15582439	0	LFA-1	143,148	ICAM-1	149,155	LFA-1	ICAM-1	3683	3383	Gene	Gene	Amino-substituted_heterocycles|nmod|START_ENTITY Amino-substituted_heterocycles|parataxis|END_ENTITY	Amino-substituted_heterocycles as isosteres of trans-cinnamides : design and synthesis of heterocyclic_biaryl_sulfides as potent antagonists of LFA-1 / ICAM-1 binding .
16116032	0	LFA-1	100,105	ICAM-1	45,51	LFA-1	ICAM-1	3683	3383	Gene	Gene	interactions|compound|START_ENTITY involved|nsubjpass|interactions express|parataxis|involved express|xcomp|END_ENTITY	Germinal center dendritic cells express more ICAM-1 than extrafollicular dendritic cells and ICAM-1 / LFA-1 interactions are involved in the capacity of dendritic cells to induce PBMCs proliferation .
16250049	0	LFA-1	93,98	ICAM-1	86,92	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	dependent|dep|START_ENTITY END_ENTITY|parataxis|dependent	Early intrahepatic antigen-specific retention of na ve CD8 + T cells is predominantly ICAM-1 / LFA-1 dependent in mice .
1672776	0	LFA-1	62,67	ICAM-1	26,32	LFA-1	ICAM-1	3683	3383	Gene	Gene	integrin|compound|START_ENTITY domain|nmod|integrin END_ENTITY|nmod|domain	Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit .
1676615	0	LFA-1	18,23	ICAM-1	46,52	LFA-1	ICAM-1	3683	3383	Gene	Gene	cell-associated|nsubj|START_ENTITY cell-associated|dobj|cluster cluster|compound|END_ENTITY	B cell-associated LFA-1 and T cell-associated ICAM-1 transiently cluster in the area of contact between interacting cells .
1680610	0	LFA-1	65,70	ICAM-1	111,117	LFA-1	ICAM-1	3683	3383	Gene	Gene	leukocyte_function_associated_antigen-1|appos|START_ENTITY leukocyte_function_associated_antigen-1|appos|END_ENTITY	Increased expression of leukocyte_function_associated_antigen-1 -LRB- LFA-1 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by alveolar macrophages of patients with pulmonary_sarcoidosis .
1680920	0	LFA-1	12,17	ICAM-1	18,24	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|interactions interactions|compound|END_ENTITY	The role of LFA-1 / ICAM-1 interactions during murine T lymphocyte development .
1682230	0	LFA-1	144,149	ICAM-1	62,68	LFA-1	ICAM-1	3683	3383	Gene	Gene	lymphocyte_function_associated_antigen_1|appos|START_ENTITY infiltration|nmod|lymphocyte_function_associated_antigen_1 correlated|nmod|infiltration correlated|nsubj|expression expression|nmod|intercellular_adhesion_molecule_1 intercellular_adhesion_molecule_1|appos|END_ENTITY	Keratinocyte expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- correlated with infiltration of lymphocyte_function_associated_antigen_1 -LRB- LFA-1 -RRB- positive cells in evolving allergic_contact_dermatitis reactions .
16920492	0	LFA-1	63,68	ICAM-1	14,20	LFA-1	ICAM-1	3683	3383	Gene	Gene	pathway|compound|START_ENTITY activates|dobj|pathway activates|nsubj|Engagement Engagement|nmod|END_ENTITY	Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1 / ICAM-3 cell adhesion pathway in mononuclear phagocytes .
16923022	0	LFA-1	61,66	ICAM-1	42,48	LFA-1	ICAM-1	3683	3383	Gene	Gene	peptides|nmod|START_ENTITY peptides|compound|END_ENTITY	Characterization of binding properties of ICAM-1 peptides to LFA-1 : inhibitors of T-cell adhesion .
16937496	0	LFA-1	64,69	ICAM-1	31,37	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	receptors|xcomp|START_ENTITY receptors|nsubj|Expression Expression|nmod|END_ENTITY	Expression and significance of ICAM-1 and its counter receptors LFA-1 and Mac-1 in experimental acute_pancreatitis of rats .
1707641	0	LFA-1	66,71	ICAM-1	59,65	LFA-1	ICAM-1	3683	3383	Gene	Gene	Re-evaluation|dep|START_ENTITY Re-evaluation|nmod|involvement involvement|nmod|END_ENTITY	Re-evaluation of the involvement of the adhesion molecules ICAM-1 / LFA-1 in syncytia formation of HIV-1-infected subclones of a CEM_T-cell_leukemic_line .
17868072	0	LFA-1	76,81	ICAM-1	0,6	LFA-1	ICAM-1	3683	3383	Gene	Gene	site|nmod|START_ENTITY peptide|nmod|site peptide|nsubj|END_ENTITY	ICAM-1 peptide inhibitors of T-cell adhesion bind to the allosteric site of LFA-1 .
18337659	0	LFA-1	21,26	ICAM-1	14,20	LFA-1	ICAM-1	3683	3383	Gene	Gene	interactions|compound|START_ENTITY prevents|nsubj|interactions Inhibition|parataxis|prevents Inhibition|nmod|END_ENTITY	Inhibition of ICAM-1 / LFA-1 interactions prevents B-cell-dependent anti-CD45RB-induced transplantation tolerance .
18781967	0	LFA-1	25,30	ICAM-1	31,37	LFA-1	ICAM-1	3683	3383	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Inhibitors targeting the LFA-1 / ICAM-1 cell-adhesion interaction : design and mechanism of action .
19184433	0	LFA-1	12,17	ICAM-1	60,66	LFA-1	ICAM-1	3683	3383	Gene	Gene	Kinetics|nmod|START_ENTITY mediated|nsubj|Kinetics mediated|nmod|END_ENTITY	Kinetics of LFA-1 mediated adhesion of human neutrophils to ICAM-1 -- role of E-selectin signaling post-activation .
19307754	0	LFA-1	7,12	ICAM-1	0,6	LFA-1	ICAM-1	3683	3383	Gene	Gene	interaction|compound|START_ENTITY contributes|nsubj|interaction END_ENTITY|appos|contributes	ICAM-1 / LFA-1 interaction contributes to the induction of endothelial cell-cell separation : implication for enhanced leukocyte diapedesis .
1972160	0	LFA-1	4,9	ICAM-1	17,23	LFA-1	ICAM-1	3689	3383	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|provides provides|nsubj|END_ENTITY	The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells .
1972656	0	LFA-1	30,35	ICAM-1	36,42	LFA-1	ICAM-1	3683	3383	Gene	Gene	involvement|nmod|START_ENTITY involvement|dep|system system|compound|END_ENTITY	Functional involvement of the LFA-1 / ICAM-1 adhesion system in the autologous mixed lymphocyte reaction .
20409465	0	LFA-1	85,90	ICAM-1	36,42	LFA-1	ICAM-1	3689	3383	Gene	Gene	bonds|compound|START_ENTITY lifetimes|nmod|bonds states|dep|lifetimes states|nmod|bonds bonds|compound|END_ENTITY	Long-lived , high-strength states of ICAM-1 bonds to beta2 integrin , II : lifetimes of LFA-1 bonds under force in leukocyte signaling .
20655213	0	LFA-1	89,94	ICAM-1	95,101	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Discovery of tetrahydroisoquinoline -LRB- THIQ -RRB- derivatives as potent and orally bioavailable LFA-1 / ICAM-1 antagonists .
21078912	0	LFA-1	113,118	ICAM-1	53,59	LFA-1	ICAM-1	3683	3383	Gene	Gene	conversion|compound|START_ENTITY not|nmod|conversion critical|parataxis|not critical|nsubj|Occupancy Occupancy|nmod|LFA-1 LFA-1|nmod|END_ENTITY	Occupancy of lymphocyte LFA-1 by surface-immobilized ICAM-1 is critical for TCR - but not for chemokine-triggered LFA-1 conversion to an open headpiece high-affinity state .
21109434	0	LFA-1	114,119	ICAM-1	120,126	LFA-1	ICAM-1	3683	3383	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Structure-activity relationship -LRB- SAR -RRB- of the a-amino_acid residue of potent tetrahydroisoquinoline -LRB- THIQ -RRB- - derived LFA-1 / ICAM-1 antagonists .
21536861	0	LFA-1	62,67	ICAM-1	68,74	LFA-1	ICAM-1	3683	3383	Gene	Gene	stabilization|nmod|START_ENTITY stabilization|dep|bonds bonds|compound|END_ENTITY	Kindlin-3 is required for the stabilization of TCR-stimulated LFA-1 : ICAM-1 bonds critical for lymphocyte arrest and spreading on dendritic cells .
24487103	0	LFA-1	94,99	ICAM-1	87,93	LFA-1	ICAM-1	3683	3383	Gene	Gene	studied|nsubj|START_ENTITY effect|parataxis|studied effect|nmod|efficacy efficacy|nmod|peptides peptides|nmod|END_ENTITY	The effect of acidic pH on the inhibitory efficacy of peptides against the interaction ICAM-1 / LFA-1 studied by surface plasmon resonance -LRB- SPR -RRB- .
2477252	1	LFA-1	105,110	ICAM-1	111,117	LFA-1	ICAM-1	3683	3383	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	The binding is elicited by both CD2/LFA -3 and LFA-1 / ICAM-1 interactions .
24900456	0	LFA-1	36,41	ICAM-1	42,48	LFA-1	ICAM-1	3683	3383	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|dep|SAR_1118 SAR_1118|compound|END_ENTITY	Discovery and Development of Potent LFA-1 / ICAM-1 Antagonist SAR_1118 as an Ophthalmic Solution for Treating Dry_Eye .
24945611	0	LFA-1	74,79	ICAM-1	105,111	LFA-1	ICAM-1	3683	3383	Gene	Gene	mobility|nmod|START_ENTITY restricts|dobj|mobility restricts|nmod|nano-aggregates nano-aggregates|compound|END_ENTITY	Priming by chemokines restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nano-aggregates on human mature dendritic cells .
2497351	0	LFA-1	57,62	ICAM-1	77,83	LFA-1	ICAM-1	3683	3383	Gene	Gene	ligand|nmod|START_ENTITY ligand|nmod|END_ENTITY	Functional cloning of ICAM-2 , a cell adhesion ligand for LFA-1 homologous to ICAM-1 .
25032811	0	LFA-1	125,130	ICAM-1	172,178	LFA-1	ICAM-1	3683	3383	Gene	Gene	leukocyte_function-associated_antigen-1|appos|START_ENTITY interactions|nmod|leukocyte_function-associated_antigen-1 based|nmod|interactions based|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	FRET based quantification and screening technology platform for the interactions of leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- with intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- .
25613092	0	LFA-1	99,104	ICAM-1	105,111	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Anti-OX40L monoclonal antibody prolongs secondary heart allograft survival based on CD40/CD40L and LFA-1 / ICAM-1 blockade .
26410859	0	LFA-1	49,54	ICAM-1	55,61	LFA-1	ICAM-1	3683	3383	Gene	Gene	cells|amod|START_ENTITY stiffness|nmod|cells stiffness|dep|interaction interaction|compound|END_ENTITY	Substrate stiffness of endothelial cells directs LFA-1 / ICAM-1 interaction : A physical trigger of immune-related diseases ?
3134364	0	LFA-1	42,47	ICAM-1	101,107	LFA-1	ICAM-1	3683	3383	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	Lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- interaction with intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells .
3315233	0	LFA-1	110,115	ICAM-1	44,50	LFA-1	ICAM-1	3683	3383	Gene	Gene	lymphocyte_function-associated_antigen_1|appos|START_ENTITY ligand|nmod|lymphocyte_function-associated_antigen_1 ligand|nsubj|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	Purified intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is a ligand for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
3525675	0	LFA-1	63,68	ICAM-1	41,47	LFA-1	ICAM-1	3683	3383	Gene	Gene	distinct|nmod|START_ENTITY molecule|amod|distinct molecule|appos|END_ENTITY	A human intercellular adhesion molecule -LRB- ICAM-1 -RRB- distinct from LFA-1 .
7518468	0	LFA-1	33,38	ICAM-1	71,77	LFA-1	ICAM-1	3683	3383	Gene	Gene	domain|nmod|START_ENTITY Involvement|nmod|domain Involvement|nmod|ligands ligands|amod|END_ENTITY	Involvement of the `` I '' domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3 .
7519104	0	LFA-1	25,30	ICAM-1	31,37	LFA-1	ICAM-1	3683	3383	Gene	Gene	aspects|nmod|START_ENTITY aspects|dep|pathways pathways|compound|END_ENTITY	Morphological aspects of LFA-1 / ICAM-1 and VLA4/VCAM -1 adhesion pathways in human lymph nodes .
7523142	0	LFA-1	28,33	ICAM-1	34,40	LFA-1	ICAM-1	3689	3383	Gene	Gene	VCAM-1|compound|START_ENTITY VCAM-1|dep|END_ENTITY	Adhesion molecules from the LFA-1 / ICAM-1 ,3 and VLA-4 / VCAM-1 pathways on T lymphocytes and vascular endothelium in Graves ' and Hashimoto 's _ thyroid_glands .
7539005	0	LFA-1	122,127	ICAM-1	167,173	LFA-1	ICAM-1	3683	3383	Gene	Gene	binding|nmod|START_ENTITY important|nmod|binding Leukocyte_function-associated_antigen-1|amod|important Leukocyte_function-associated_antigen-1|appos|END_ENTITY	Identification of amino_acids in the CD11a I-domain important for binding of the leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- to intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- Leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- is a cell surface adhesion receptor for intercellular_adhesion_molecule-1 , -2 , and -3 -LRB- ICAM-1 , -2 , -3 -RRB- .
7586691	0	LFA-1	222,227	ICAM-1	168,174	LFA-1	ICAM-1	16414(Tax:10090)	15894(Tax:10090)	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Prevention of adoptive transfer of murine Sj gren 's syndrome into severe_combined_immunodeficient -LRB- SCID -RRB- mice by antibodies against intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- .
7641842	0	LFA-1	55,60	ICAM-1	36,42	LFA-1	ICAM-1	3683	3383	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	Monoclonal antibodies against CD54 -LRB- ICAM-1 -RRB- and CD11a -LRB- LFA-1 -RRB- prevent and inhibit endotoxin-induced uveitis .
7642561	0	LFA-1	81,86	ICAM-1	162,168	LFA-1	ICAM-1	3683	3383	Gene	Gene	START_ENTITY|acl|required required|nmod|intercellular_adhesion_molecule_1 intercellular_adhesion_molecule_1|appos|END_ENTITY	A binding interface on the I domain of lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- required for specific interaction with intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- .
7684326	2	LFA-1	47,52	ICAM-1	53,59	LFA-1	ICAM-1	3683	3383	Gene	Gene	Role|nmod|START_ENTITY Role|dep|molecules molecules|compound|END_ENTITY	Role of LFA-1 / ICAM-1 and CD2/LFA -3 adhesion molecules in CD3-induced proliferative response .
7707308	0	LFA-1	51,56	ICAM-1	57,63	LFA-1	ICAM-1	3683	3383	Gene	Gene	inhibitors|nmod|START_ENTITY based|nmod|inhibitors thiazole|acl|based thiazole|parataxis|mediated mediated|nsubj|END_ENTITY	Novel thiazole based heterocycles as inhibitors of LFA-1 / ICAM-1 mediated cell adhesion .
7821966	0	LFA-1	7,12	ICAM-1	0,6	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	interactions|compound|START_ENTITY END_ENTITY|dep|interactions	ICAM-1 / LFA-1 interactions in T-lymphocyte activation and adhesion to cells of the blood-retina barrier in the rat .
7844171	0	LFA-1	0,5	ICAM-1	120,126	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	integrin|compound|START_ENTITY redistribution|nsubj|integrin redistribution|nmod|END_ENTITY	LFA-1 integrin redistribution during T-cell hybridoma invasion of hepatocyte cultures and manganese-induced adhesion to ICAM-1 .
7852849	0	LFA-1	13,18	ICAM-1	19,25	LFA-1	ICAM-1	3683	3383	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|parataxis|lymphoid lymphoid|nsubj|stimulation stimulation|amod|dependent dependent|amod|END_ENTITY	Evidence for LFA-1 / ICAM-1 dependent stimulation of protein tyrosine phosphorylation in human B lymphoid cell lines during homotypic adhesion .
7868060	0	LFA-1	23,28	ICAM-1	16,22	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	molecule|compound|START_ENTITY molecule|compound|END_ENTITY	-LSB- Involvement of ICAM-1 / LFA-1 adhesion molecule set in rat orthotopic liver transplantation -RSB- .
7879317	0	LFA-1	97,102	ICAM-1	43,49	LFA-1	ICAM-1	3683	3383	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- in peripheral blood mononuclear cell activation by human renal_carcinoma cells .
7901223	0	LFA-1	46,51	ICAM-1	52,58	LFA-1	ICAM-1	3683	3383	Gene	Gene	adhesion|compound|START_ENTITY adhesion|compound|END_ENTITY	ICAM-3 interacts with LFA-1 and regulates the LFA-1 / ICAM-1 cell adhesion pathway .
7903074	0	LFA-1	8,13	ICAM-1	14,20	LFA-1	ICAM-1	3683	3383	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of LFA-1 / ICAM-1 in interleukin-2-stimulated lymphocyte proliferation .
7908635	0	LFA-1	33,38	ICAM-1	26,32	LFA-1	ICAM-1	3683	3383	Gene	Gene	adhesion|compound|START_ENTITY requirements|dep|adhesion requirements|nmod|END_ENTITY	Different requirements of ICAM-1 / LFA-1 adhesion in allorecognition and self-restricted antigen recognition by class II-specific T cell clones .
7909511	0	LFA-1	9,14	ICAM-1	41,47	LFA-1	ICAM-1	3683	3383	Gene	Gene	contains|nsubj|START_ENTITY contains|dobj|site site|compound|END_ENTITY	Integrin LFA-1 alpha subunit contains an ICAM-1 binding site in domains V and VI .
7910490	0	LFA-1	85,90	ICAM-1	91,97	LFA-1	ICAM-1	3683	3383	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	TNF-induced microvascular pathology : active role for platelets and importance of the LFA-1 / ICAM-1 interaction .
7910869	0	LFA-1	11,16	ICAM-1	4,10	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	interaction|nsubj|START_ENTITY END_ENTITY|parataxis|interaction	The ICAM-1 / LFA-1 interaction in glomerular leukocytic accumulation in anti-GBM glomerulonephritis .
7927492	0	LFA-1	92,97	ICAM-1	98,104	LFA-1	ICAM-1	3689	3383	Gene	Gene	dependence|nmod|START_ENTITY function|dep|dependence function|dep|END_ENTITY	Human hepatoma cells expressing MHC antigens display accessory cell function : dependence on LFA-1 / ICAM-1 interaction .
8094944	0	LFA-1	11,16	ICAM-1	17,23	LFA-1	ICAM-1	3683	3383	Gene	Gene	Discordant|xcomp|START_ENTITY expression|dep|Discordant expression|compound|END_ENTITY	Discordant LFA-1 / ICAM-1 expression in a case of secondary plasma_cell_leukemia associated with subcutaneous plasmacytoma .
8096435	0	LFA-1	115,120	ICAM-1	166,172	LFA-1	ICAM-1	3683	3383	Gene	Gene	lymphocyte_function-associated_antigen-1|appos|START_ENTITY lymphocyte_function-associated_antigen-1|appos|END_ENTITY	CD45 mAb induces cell adhesion in peripheral blood mononuclear cells via lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- and intercellular_cell_adhesion_molecule_1 -LRB- ICAM-1 -RRB- .
8526098	0	LFA-1	96,101	ICAM-1	102,108	LFA-1	ICAM-1	3683	3383	Gene	Gene	recognition|compound|START_ENTITY recognition|compound|END_ENTITY	T-lymphocyte proliferation stimulated by alpha beta TCR/CD2 bispecific antibody is dependent on LFA-1 / ICAM-1 recognition of accessory cells .
8982116	0	LFA-1	77,82	ICAM-1	83,89	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Substance_P promotes lymphocyte-endothelial cell adhesion preferentially via LFA-1 / ICAM-1 interactions .
9068010	0	LFA-1	19,24	ICAM-1	12,18	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY Role|dep|pathway Role|nmod|END_ENTITY	Role of the ICAM-1 / LFA-1 pathway during the development of autoimmune_dacryoadenitis in an animal model for Sj __ gren 's _ syndrome .
9129035	0	LFA-1	77,82	ICAM-1	83,89	LFA-1	ICAM-1	3683	3383	Gene	Gene	molecules|compound|START_ENTITY molecules|compound|END_ENTITY	Interleukin-4 induces homotypic aggregation of human mast cells by promoting LFA-1 / ICAM-1 adhesion molecules .
9283612	0	LFA-1	7,12	ICAM-1	0,6	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	ICAM-1 / LFA-1 expression in acute_osteodestructive_joint_lesions in collagen-induced arthritis in rats .
9337197	0	LFA-1	132,137	ICAM-1	125,131	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	START_ENTITY|dep|Regulation Regulation|nmod|allograft allograft|acl|induced induced|advcl|blocking blocking|dobj|END_ENTITY	Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1 / LFA-1 adhesion .
9381658	0	LFA-1	18,23	ICAM-1	24,30	LFA-1	ICAM-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|influences influences|nsubj|END_ENTITY	Adhesion molecule LFA-1 / ICAM-1 influences on LPS-induced megakaryocytic emperipolesis in the rat bone marrow .
9452454	0	LFA-1	25,30	ICAM-1	46,52	LFA-1	ICAM-1	3683	3383	Gene	Gene	domain|nmod|START_ENTITY interacts|nsubj|domain interacts|nmod|domain domain|compound|END_ENTITY	The I domain of integrin LFA-1 interacts with ICAM-1 domain 1 at residue Glu-34 but not Gln-73 .
9499066	0	LFA-1	29,34	ICAM-1	141,147	LFA-1	ICAM-1	3683	3383	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing susceptible|nsubj|cells susceptible|nmod|infection infection|nmod|particles particles|acl|bearing bearing|dobj|END_ENTITY	T cells expressing activated LFA-1 are more susceptible to infection with human_immunodeficiency_virus_type_1 particles bearing host-encoded ICAM-1 .
9531273	0	LFA-1	104,109	ICAM-1	110,116	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Purified MHC class I and peptide complexes activate naive CD8 + T cells independently of the CD28/B7 and LFA-1 / ICAM-1 costimulatory interactions .
9574521	0	LFA-1	30,35	ICAM-1	47,53	LFA-1	ICAM-1	3683	3383	Gene	Gene	requirements|nmod|START_ENTITY requirements|amod|binding binding|nmod|aggregation aggregation|amod|END_ENTITY	Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation .
9587631	0	LFA-1	85,90	ICAM-1	35,41	LFA-1	ICAM-1	3683	3383	Gene	Gene	leucocyte_function-associated_antigen-1|appos|START_ENTITY END_ENTITY|appos|leucocyte_function-associated_antigen-1	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , leucocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- and leucocyte infiltration in proliferative human glomerulonephritis .
9671153	0	LFA-1	32,37	ICAM-1	85,91	LFA-1	ICAM-1	3683	3383	Gene	Gene	form|nmod|START_ENTITY Expression|nmod|form Expression|nmod|END_ENTITY	Expression of a soluble form of LFA-1 and demonstration of its binding activity with ICAM-1 .
9820482	0	LFA-1	0,5	ICAM-1	23,29	LFA-1	ICAM-1	16408(Tax:10090)	15894(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production .
9951802	0	LFA-1	129,134	ICAM-1	122,128	LFA-1	ICAM-1	3683	3383	Gene	Gene	Atherosclerosis|parataxis|START_ENTITY Atherosclerosis|nmod|implication implication|nmod|END_ENTITY	Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1 / LFA-1 pathway in atherogenesis .
10639327	0	LFA-1	120,125	ICAM-3	19,25	LFA-1	ICAM-3	3683	3385	Gene	Gene	redistribution|nmod|START_ENTITY cell|nmod|redistribution interactions|dep|cell interactions|compound|END_ENTITY	Low-affinity LFA-1 / ICAM-3 interactions augment LFA-1 / ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1 .
10639327	0	LFA-1	13,18	ICAM-3	19,25	LFA-1	ICAM-3	3683	3385	Gene	Gene	START_ENTITY|dep|interactions interactions|compound|END_ENTITY	Low-affinity LFA-1 / ICAM-3 interactions augment LFA-1 / ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1 .
10639327	0	LFA-1	47,52	ICAM-3	19,25	LFA-1	ICAM-3	3683	3385	Gene	Gene	interactions|dep|START_ENTITY interactions|compound|END_ENTITY	Low-affinity LFA-1 / ICAM-3 interactions augment LFA-1 / ICAM-1-mediated T cell adhesion and signaling by redistribution of LFA-1 .
1448173	0	LFA-1	48,53	ICAM-3	21,27	LFA-1	ICAM-3	3683	3385	Gene	Gene	ligand|nmod|START_ENTITY cloning|appos|ligand cloning|nmod|END_ENTITY	Molecular cloning of ICAM-3 , a third ligand for LFA-1 , constitutively expressed on resting leukocytes .
16920492	0	LFA-1	63,68	ICAM-3	69,75	LFA-1	ICAM-3	3683	3385	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Engagement of ICAM-1 by major group rhinoviruses activates the LFA-1 / ICAM-3 cell adhesion pathway in mononuclear phagocytes .
7516162	0	LFA-1	60,65	ICAM-3	22,28	LFA-1	ICAM-3	3683	3385	Gene	Gene	counter-receptor|nmod|START_ENTITY Expression|appos|counter-receptor Expression|nmod|ICAM-R ICAM-R|appos|END_ENTITY	Expression of ICAM-R -LRB- ICAM-3 -RRB- , a novel counter-receptor for LFA-1 , in rheumatoid_and_nonrheumatoid_synovium .
7531103	0	LFA-1	0,5	ICAM-3	22,28	LFA-1	ICAM-3	3683	3385	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	LFA-1 binding site in ICAM-3 contains a conserved motif and non-contiguous amino_acids .
7544645	0	LFA-1	78,83	ICAM-3	92,98	LFA-1	ICAM-3	3683	3385	Gene	Gene	ICAM-1|compound|START_ENTITY ICAM-1|appos|interactions interactions|compound|END_ENTITY	B-cell homotypic adhesion through exon-A restricted epitopes of CD45 involves LFA-1 / ICAM-1 , ICAM-3 interactions , and induces coclustering of CD45 and LFA-1 .
7901223	0	LFA-1	22,27	ICAM-3	0,6	LFA-1	ICAM-3	3683	3385	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ICAM-3 interacts with LFA-1 and regulates the LFA-1 / ICAM-1 cell adhesion pathway .
8223855	0	LFA-1	18,23	ICAM-3	0,6	LFA-1	ICAM-3	3689	3385	Gene	Gene	counterreceptor|compound|START_ENTITY END_ENTITY|appos|counterreceptor	ICAM-3 , the third LFA-1 counterreceptor , is a co-stimulatory molecule for both resting and activated T lymphocytes .
8547030	0	LFA-1	11,16	ICAM-3	4,10	LFA-1	ICAM-3	3683	3385	Gene	Gene	interaction|compound|START_ENTITY critical|nsubj|interaction END_ENTITY|parataxis|critical	The ICAM-3 / LFA-1 interaction is critical for epidermal Langerhans cell alloantigen presentation to CD4 + T cells .
8660847	0	LFA-1	40,45	ICAM-3	46,52	LFA-1	ICAM-3	3683	3385	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|dep|mediated	Homotypic interactions mediated through LFA-1 / ICAM-3 decrease the proliferative response of activated T cells .
8707894	0	LFA-1	0,5	ICAM-3	6,12	LFA-1	ICAM-3	3683	3385	Gene	Gene	START_ENTITY|appos|mediates mediates|nsubj|END_ENTITY	LFA-1 / ICAM-3 mediates neutrophil homotypic aggregation under fluid shear stress .
8798624	0	LFA-1	125,130	ICAM-3	71,77	LFA-1	ICAM-3	3683	3385	Gene	Gene	lymphocyte_function-associated_antigen_1|appos|START_ENTITY Localization|nmod|lymphocyte_function-associated_antigen_1 Localization|appos|END_ENTITY	Localization of the binding site on intercellular_adhesion_molecule-3 -LRB- ICAM-3 -RRB- for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
9686599	0	LFA-1	45,50	ICAM-3	68,74	LFA-1	ICAM-3	3683	3385	Gene	Gene	leukocyte_function-associated_antigen-1|appos|START_ENTITY leukocyte_function-associated_antigen-1|dep|site site|nmod|residues residues|compound|END_ENTITY	The leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- - binding site on ICAM-3 comprises residues on both faces of the first immunoglobulin domain .
12193230	0	LFA-1	94,99	IFN-gamma	44,53	LFA-1	IFN-gamma	16414(Tax:10090)	15978(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY cytokines|appos|VCAM-1 cytokines|appos|IL-2 IL-2|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
12193230	0	LFA-1	94,99	IL-10	55,60	LFA-1	IL-10	16414(Tax:10090)	16153(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY cytokines|appos|VCAM-1 cytokines|appos|IL-2 IL-2|dep|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
12847222	0	LFA-1	172,177	IL-10	148,153	LFA-1	IL-10	16408(Tax:10090)	16153(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver _ injury in the presence of TNF-alpha and IL-12 is mediated by IL-10 : a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance .
12193230	0	LFA-1	94,99	IL-2	38,42	LFA-1	IL-2	16414(Tax:10090)	16183(Tax:10090)	Gene	Gene	VCAM-1|dep|START_ENTITY cytokines|appos|VCAM-1 cytokines|appos|END_ENTITY	Differential expression of cytokines -LRB- IL-2 , IFN-gamma , IL-10 -RRB- and adhesion molecules -LRB- VCAM-1 , LFA-1 , CD44 -RRB- between spleen and lymph nodes associates with remission in chronic relapsing experimental autoimmune encephalomyelitis .
2547869	0	LFA-1	13,18	IL-4	0,4	LFA-1	IL-4	3683	3565	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-4 induces LFA-1 and LFA-3 expression on Burkitt 's _ lymphoma cell lines .
21532911	0	LFA-1	40,45	IL-8	71,75	LFA-1	IL-8	3689	3576	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling and Dynamics of Activation of LFA-1 and Mac-1 by Immobilized IL-8 .
10766246	0	LFA-1	9,14	JAB1	63,67	LFA-1	JAB1	3689	10987	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity .
11812992	0	LFA-1	42,47	JAM-1	0,5	LFA-1	JAM-1	3683	50848	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	JAM-1 is a ligand of the beta -LRB- 2 -RRB- integrin LFA-1 involved in transendothelial migration of leukocytes .
1378320	0	LFA-1	130,135	LFA-1	87,92	LFA-1	LFA-1	3683	3683	Gene	Gene	cells|compound|START_ENTITY primitive|nmod|cells primitive|nsubj|Expression Expression|nmod|molecules molecules|nmod|cells cells|dep|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
1378320	0	LFA-1	87,92	LFA-1	130,135	LFA-1	LFA-1	3683	3683	Gene	Gene	cells|dep|START_ENTITY molecules|nmod|cells Expression|nmod|molecules primitive|nsubj|Expression primitive|nmod|cells cells|compound|END_ENTITY	Expression and function of adhesion molecules on human hematopoietic stem cells : CD34 + LFA-1 - cells are more primitive than CD34 + LFA-1 + cells .
10828007	0	LFA-1	44,49	SDF-1	14,19	LFA-1	SDF-1	3683	6387	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The chemokine SDF-1 activates the integrins LFA-1 , VLA-4 , and VLA-5 on immature human CD34 -LRB- + -RRB- cells : role in transendothelial/stromal migration and engraftment of NOD/SCID mice .
7759886	0	LFA-1	117,122	TNF-alpha	78,87	LFA-1	TNF-alpha	308995(Tax:10116)	24835(Tax:10116)	Gene	Gene	utilizes|dobj|START_ENTITY utilizes|nsubj|END_ENTITY	In vivo blood monocyte migration to acute inflammatory reactions , IL-1_alpha , TNF-alpha , IFN-gamma , and C5a utilizes LFA-1 , Mac-1 , and VLA-4 .
11857637	0	LFA-1	14,19	VCAM-1	37,43	LFA-1	VCAM-1	3683	7412	Gene	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of LFA-1 / ICAM-1 and VLA-4 / VCAM-1 as a therapeutic approach to inflammation and autoimmune_diseases .
10510363	0	LFA-1	0,5	ZAP-70	59,65	LFA-1	ZAP-70	3683	7535	Gene	Gene	LFA-1|amod|START_ENTITY signals|amod|LFA-1 involve|nsubj|signals involve|dobj|kinase kinase|compound|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
10510363	0	LFA-1	9,14	ZAP-70	59,65	LFA-1	ZAP-70	3683	7535	Gene	Gene	signals|amod|START_ENTITY involve|nsubj|signals involve|dobj|kinase kinase|compound|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
21200022	0	LFA-1	13,18	ZAP-70	35,41	LFA-1	ZAP-70	3683	7535	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes .
21200022	0	LFA-1	82,87	ZAP-70	35,41	LFA-1	ZAP-70	3683	7535	Gene	Gene	expression|nmod|START_ENTITY regulate|dobj|expression signals|xcomp|regulate signals|nmod|END_ENTITY	The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes .
21850260	0	LFA-1	29,34	gp120	13,18	LFA-1	gp120	3683	3700	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin -LRB- LtxA -RRB- .
15749873	0	LFA-1	46,51	intercellular_adhesion_molecule-1	12,45	LFA-1	intercellular adhesion molecule-1	3683	3383	Gene	Gene	interactions|compound|START_ENTITY role|dep|interactions role|nmod|END_ENTITY	The role of intercellular_adhesion_molecule-1 / LFA-1 interactions in the generation of tumor-specific CD8 + T cell responses .
3134364	0	LFA-1	42,47	intercellular_adhesion_molecule-1	66,99	LFA-1	intercellular adhesion molecule-1	3683	3383	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- interaction with intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells .
15023143	0	LFA-1	89,94	intercellular_adhesion_molecule-2	24,57	LFA-1	intercellular adhesion molecule-2	3683	414387(Tax:9823)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of pig intercellular_adhesion_molecule-2 and its interaction with human LFA-1 .
11929876	0	LFA-1	22,27	intercellular_adhesion_molecule_1	64,97	LFA-1	intercellular adhesion molecule 1	3689	3383	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in shear flow .
2475518	0	LFA-1	105,110	interferon-gamma	11,27	LFA-1	interferon-gamma	3683	3458	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of interferon-gamma -LRB- IFN-gamma -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on the expression of LFA-1 in the moderate phenotype of leukocyte_adhesion_deficiency -LRB- LAD -RRB- .
9420139	0	LFA-1	49,54	interleukin-7	15,28	LFA-1	interleukin-7	3683	3574	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
3301869	0	LFA-1	56,61	leukocyte_function-associated_antigen-1	15,54	LFA-1	leukocyte function-associated antigen-1	3683	3683	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- in the invasion of hepatocyte cultures by lymphoma and T-cell hybridoma cells .
2553807	0	LFA-1	109,114	lymphocyte_function-associated_antigen	69,107	LFA-1	lymphocyte function-associated antigen	3683	3683	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Heterogeneous distribution and transmembrane signaling properties of lymphocyte_function-associated_antigen -LRB- LFA-1 -RRB- in human lymphocyte subsets .
3065089	0	LFA-1	69,74	lymphocyte_function-associated_antigen-1	27,67	LFA-1	lymphocyte function-associated antigen-1	16414(Tax:10090)	16414(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Higher level expression of lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- on in vivo natural killer cells .
24593905	0	LFA-1	171,176	lymphocyte_function-associated_antigen_1	129,169	LFA-1	lymphocyte function-associated antigen 1	3683	3683	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Application of encoded library technology -LRB- ELT -RRB- to a protein-protein interaction target : discovery of a potent class of integrin lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- antagonists .
2685124	0	LFA-1	69,74	lymphocyte_function-associated_antigen_1	27,67	LFA-1	lymphocyte function-associated antigen 1	16414(Tax:10090)	16414(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- on epidermotropic and non-epidermotropic T-cell clones .
2956113	0	LFA-1	63,68	lymphocyte_function-associated_antigen_1	21,61	LFA-1	lymphocyte function-associated antigen 1	3683	3683	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of monocyte lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- in accessory cell function .
7688472	0	LFA-1	16,21	phospholipase_C-gamma_1	40,63	LFA-1	phospholipase C-gamma 1	3683	5335	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|amod|END_ENTITY	Beta_2-integrin LFA-1 signaling through phospholipase_C-gamma_1 activation .
10626910	0	LFA-3	27,32	CD2	56,59	LFA-3	CD2	965	914	Gene	Gene	Low|nmod|START_ENTITY Low|parataxis|independent independent|nsubj|protein protein|nmod|cells cells|compound|END_ENTITY	Low affinity binding of an LFA-3 / IgG1 fusion protein to CD2 + T cells is independent of cell activation .
11970990	0	LFA-3	43,48	CD2	129,132	LFA-3	CD2	965	914	Gene	Gene	protein|compound|START_ENTITY Alefacept|appos|protein induces|nsubj|Alefacept induces|dobj|signaling signaling|nmod|cells cells|amod|END_ENTITY	Alefacept , an immunomodulatory recombinant LFA-3 / IgG1 fusion protein , induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2 -LRB- + -RRB- cells .
1279193	0	LFA-3	63,68	CD2	54,57	LFA-3	CD2	965	914	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|interaction interaction|nmod|END_ENTITY	Enhancement of B cell responses by the interaction of CD2 with LFA-3 .
1710564	0	LFA-3	6,11	CD2	42,45	LFA-3	CD2	965	12481(Tax:10090)	Gene	Gene	START_ENTITY|acl|studied studied|nmod|END_ENTITY	Mouse LFA-3 studied with chimeric soluble CD2 shows preferential expression on lymphoid cells .
2448792	0	LFA-3	141,146	CD2	42,45	LFA-3	CD2	965	914	Gene	Gene	antigen|appos|START_ENTITY role|nmod|antigen define|dobj|role mutant|xcomp|define mutant|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 -LRB- LFA-3 -RRB- in T-cell activation .
2458315	0	LFA-3	10,15	CD2	89,92	LFA-3	CD2	965	914	Gene	Gene	gene|compound|START_ENTITY located|nsubjpass|gene located|nmod|gene gene|nmod|END_ENTITY	The human LFA-3 gene is located at the same chromosome band as the gene for its receptor CD2 .
2459236	0	LFA-3	51,56	CD2	93,96	LFA-3	CD2	965	914	Gene	Gene	lymphocyte_function-associated_antigen-3|appos|START_ENTITY activates|nsubj|lymphocyte_function-associated_antigen-3 activates|dobj|thymocytes thymocytes|nmod|pathway pathway|compound|END_ENTITY	Purified lymphocyte_function-associated_antigen-3 -LRB- LFA-3 -RRB- activates human thymocytes via the CD2 pathway .
2460248	0	LFA-3	32,37	CD2	19,22	LFA-3	CD2	965	914	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|nmod|ligand	The interaction of CD2 with its LFA-3 ligand expressed by autologous erythrocytes results in enhancement of B cell responses .
2471647	0	LFA-3	25,30	CD2	36,39	LFA-3	CD2	965	914	Gene	Gene	antibody|nmod|START_ENTITY antibody|appos|ligand ligand|compound|END_ENTITY	A monoclonal antibody to LFA-3 , the CD2 ligand , specifically immobilizes major histocompatibility complex proteins .
2834437	0	LFA-3	36,41	CD2	15,18	LFA-3	CD2	965	914	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CD2 with its ligand , LFA-3 , in human T cell proliferation .
3313052	0	LFA-3	3,8	CD2	88,91	LFA-3	CD2	965	914	Gene	Gene	cDNA|compound|START_ENTITY encodes|nsubj|cDNA encodes|dobj|protein protein|nmod|END_ENTITY	An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2 .
7505442	0	LFA-3	10,15	CD2	111,114	LFA-3	CD2	965	914	Gene	Gene	CD58|appos|START_ENTITY area|nsubj|CD58 area|nmod|face face|nmod|domain domain|compound|END_ENTITY	The CD58 -LRB- LFA-3 -RRB- binding site is a localized and highly charged surface area on the AGFCC ` C '' face of the human CD2 adhesion domain .
7520278	0	LFA-3	45,50	CD2	29,32	LFA-3	CD2	965	914	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Human cell-adhesion molecule CD2 binds CD58 -LRB- LFA-3 -RRB- with a very low affinity and an extremely fast dissociation rate but does not bind CD48 or CD59 .
8636222	0	LFA-3	38,43	CD2	17,20	LFA-3	CD2	965	914	Gene	Gene	interaction|nmod|START_ENTITY interaction|nsubj|Visualization Visualization|nmod|END_ENTITY	Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area .
10959555	0	LFA-3	14,19	CD58	21,25	LFA-3	CD58	965	965	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of LFA-3 -LRB- CD58 -RRB- by dexamethasone and retinoic_acids in vitro .
1375302	0	LFA-3	65,70	ICAM-1	47,53	LFA-3	ICAM-1	965	3383	Gene	Gene	CD54|appos|START_ENTITY CD54|appos|END_ENTITY	Expression of surface adhesion molecules CD54 -LRB- ICAM-1 -RRB- and CD58 -LRB- LFA-3 -RRB- in adult acute_leukemia : relationship with initial characteristics and prognosis .
10099837	0	LFA-3	69,74	lymphocyte_function_associated_antigen-3	27,67	LFA-3	lymphocyte function associated antigen-3	965	965	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of lymphocyte_function_associated_antigen-3 -LRB- LFA-3 -RRB- at the blood-brain barrier .
8417340	0	LFB1	83,87	HNF1	89,93	LFB1	HNF1	378589(Tax:8355)	378589(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Developmental regulation and tissue distribution of the liver transcription factor LFB1 -LRB- HNF1 -RRB- in Xenopus_laevis .
8735941	0	LFB1	80,84	HNF1_alpha	68,78	LFB1	HNF1 alpha	378589(Tax:8355)	378589(Tax:8355)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation and function of the tissue-specific transcription factor HNF1_alpha -LRB- LFB1 -RRB- during Xenopus development .
15663956	0	LGA	50,53	liver-type_glutaminase	26,48	LGA	liver-type glutaminase	27165	27165	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Lack of expression of the liver-type_glutaminase -LRB- LGA -RRB- mRNA in human malignant_gliomas .
19330599	0	LGALS2	12,18	Galectin-2	0,10	LGALS2	Galectin-2	3957	3957	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Galectin-2 -LRB- LGALS2 -RRB- 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid_arthritis .
24755837	0	LGALS3	20,26	galectin-3	28,38	LGALS3	galectin-3	3958	3958	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|END_ENTITY	Characterization of LGALS3 -LRB- galectin-3 -RRB- as a player in DNA damage response .
22864925	0	LGALS3BP	0,8	vascular_endothelial_growth_factor	72,106	LGALS3BP	vascular endothelial growth factor	3959	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	LGALS3BP , lectin_galactoside-binding soluble 3 binding protein , induces vascular_endothelial_growth_factor in human breast_cancer cells and promotes angiogenesis .
26687600	0	LGG-1	84,89	Atg8	69,73	LGG-1	Atg8	174050(Tax:6239)	852200(Tax:4932)	Gene	Gene	Homologs|amod|START_ENTITY Homologs|compound|END_ENTITY	Structural Basis of the Differential Function of the Two C. __ elegans Atg8 Homologs , LGG-1 and LGG-2 , in Autophagy .
20523114	0	LGG-1	59,64	LGG-2	27,32	LGG-1	LGG-2	174050(Tax:6239)	177989(Tax:6239)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. _ elegans .
20523114	0	LGG-2	27,32	LGG-1	59,64	LGG-2	LGG-1	177989(Tax:6239)	174050(Tax:6239)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. _ elegans .
17681454	0	LGI1	28,32	ADAM22	42,48	LGI1	ADAM22	9211	53616	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal_dominant_lateral_temporal_epilepsy .
18974846	0	LGI1	0,4	ADAM22	22,28	LGI1	ADAM22	56839(Tax:10090)	11496(Tax:10090)	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	LGI1 and LGI4 bind to ADAM22 , ADAM23 and ADAM11 .
17387609	0	LGI3	39,43	Abeta	0,5	LGI3	Abeta	306013(Tax:10116)	54226(Tax:10116)	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|nsubj|END_ENTITY	Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes .
2365999	1	LGL-1	117,122	LGL-1	55,60	LGL-1	LGL-1	16897(Tax:10090)	16897(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|compound|END_ENTITY	NK-1 .1 + / LGL-1 + cells restricted to lysing NK targets , whereas NK-1 .1 + / LGL-1 - cells generate lymphokine-activated killer cells .
2365999	1	LGL-1	55,60	LGL-1	117,122	LGL-1	LGL-1	16897(Tax:10090)	16897(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	NK-1 .1 + / LGL-1 + cells restricted to lysing NK targets , whereas NK-1 .1 + / LGL-1 - cells generate lymphokine-activated killer cells .
16010686	0	LGMD2B	23,29	Dysferlin	0,9	LGMD2B	Dysferlin	8291	8291	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Dysferlin mutations in LGMD2B , Miyoshi_myopathy , and atypical_dysferlinopathies .
23374535	0	LGR-5	14,19	MSI-1	21,26	LGR-5	MSI-1	299802(Tax:10116)	259272(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Expression of LGR-5 , MSI-1 and DCAMKL-1 , putative stem cell markers , in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis : correlation with nuclear b-catenin .
27064449	0	LGR4	0,4	RANKL	23,28	LGR4	RANKL	107515(Tax:10090)	21943(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption .
26366338	0	LGR5	82,86	DCLK1	69,74	LGR5	DCLK1	8549	9201	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1 , MSI1 , LGR5 , and BMI1 .
26366338	0	LGR5	82,86	MSI1	76,80	LGR5	MSI1	8549	4440	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1 , MSI1 , LGR5 , and BMI1 .
26123262	0	LGR5	82,86	R-spondin_2	21,32	LGR5	R-spondin 2	8549	340419	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of R-spondin_2 in complex with the ectodomains of its receptors LGR5 and ZNRF3 .
26123262	0	LGR5	82,86	R-spondin_2	21,32	LGR5	R-spondin 2	8549	340419	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of R-spondin_2 in complex with the ectodomains of its receptors LGR5 and ZNRF3 .
19813087	0	LGR5	42,46	neurogenin_1	21,33	LGR5	neurogenin 1	8549	4762	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|expression expression|nmod|END_ENTITY	Stable expression of neurogenin_1 induces LGR5 , a novel stem cell marker , in an immortalized human neural stem cell line HB1.F3 .
16467492	0	LGR8	67,71	insulin-like_peptide_3	18,40	LGR8	insulin-like peptide 3	122042	3640	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Expression of the insulin-like_peptide_3 -LRB- INSL3 -RRB- hormone-receptor -LRB- LGR8 -RRB- system in the testis .
15708846	0	LGR8	0,4	relaxin-like_factor	30,49	LGR8	relaxin-like factor	122042	6018	Gene	Gene	signal|nsubj|START_ENTITY signal|nmod|END_ENTITY	LGR8 signal activation by the relaxin-like_factor .
3091737	0	LH-RH	57,62	LH-RH	91,96	LH-RH	LH-RH	2796	2796	Gene	Gene	START_ENTITY|nmod|test test|compound|END_ENTITY	-LSB- Study on the correlation between self-priming effect of LH-RH and luteal_insufficiency by LH-RH two step test -RSB- .
3091737	0	LH-RH	91,96	LH-RH	57,62	LH-RH	LH-RH	2796	2796	Gene	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	-LSB- Study on the correlation between self-priming effect of LH-RH and luteal_insufficiency by LH-RH two step test -RSB- .
6372946	0	LH-RH	39,44	Luteinizing_hormone-releasing_hormone	0,37	LH-RH	Luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- cells and their projections in the forebrain of the bat Myotis lucifugus lucifugus .
6788946	0	LH-RH	40,45	Prolactin	0,9	LH-RH	Prolactin	443529(Tax:9940)	443317(Tax:9940)	Gene	Gene	response|nmod|START_ENTITY release|nmod|response release|nsubj|END_ENTITY	Prolactin and LH release in response to LH-RH and TRH in ewes during dioestrus , pregnancy and post partum .
11903807	0	LH-RH	70,75	luteinizing_hormone-releasing_hormone	31,68	LH-RH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	analogue|appos|START_ENTITY analogue|nmod|END_ENTITY	Targeted cytotoxic analogue of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- only transiently decreases the gene expression of pituitary receptors for LH-RH .
19605087	0	LH-RH	60,65	luteinizing_hormone-releasing_hormone	21,58	LH-RH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Local degradation of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- in the rat central nervous system .
325980	0	LH-RH	86,91	luteinizing_hormone-releasing_hormone	47,84	LH-RH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Temporal changes in the hypothalamic and serum luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- levels and the circulating ovarian steroids during the rat oestrous cycle .
6095443	0	LH-RH	78,83	luteinizing_hormone-releasing_hormone	39,76	LH-RH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Identification and characterization of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- receptors in the endometrial tissue of pregnant rats .
6256722	0	LH-RH	106,111	luteinizing_hormone-releasing_hormone	67,104	LH-RH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Minimal steric difference study of structural requirements for the luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- receptor .
773817	0	LH-RH	49,54	luteinizing_hormone-releasing_hormone	10,47	LH-RH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- on the multiunit activity of the arcuate nucleus in the proestrous rats .
782712	0	LH-RH	90,95	luteinizing_hormone-releasing_hormone	51,88	LH-RH	luteinizing hormone-releasing hormone	100135531(Tax:10141)	100135531(Tax:10141)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- in the median eminence of the guinea_pig .
1092712	0	LH-RH	59,64	luteinizing_hormone_releasing_hormone	20,57	LH-RH	luteinizing hormone releasing hormone	2796	2796	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of synthetic luteinizing_hormone_releasing_hormone -LRB- LH-RH -RRB- on the release of gonadotropins in Cushing 's _ disease .
324526	0	LH-RH	54,59	luteinizing_hormone_releasing_hormone	15,52	LH-RH	luteinizing hormone releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of luteinizing_hormone_releasing_hormone -LRB- LH-RH -RRB- in pregnant rats .
344872	0	LH-RH	52,57	prolactin	10,19	LH-RH	prolactin	2796	5617	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolactin on the LH response to synthetic LH-RH in ovariectomized ewes .
6300718	0	LH-RH	0,5	prolactin	146,155	LH-RH	prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|acl|bearing bearing|dobj|pituitary_tumor pituitary_tumor|amod|END_ENTITY	LH-RH and dopamine levels in hypophysial stalk plasma and their relationship to plasma gonadotrophins and prolactin levels in male rats bearing a prolactin - and adrenocorticotrophin-secreting pituitary_tumor .
14697302	0	LH-beta	162,169	FSH-beta	30,38	LH-beta	FSH-beta	100174897(Tax:69293)	100174866(Tax:69293)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning and sequencing of the FSH-beta and LH_beta-subunit in the three-spined_stickleback , Gasterosteus_aculeatus , and effects of photoperiod and temperature on LH-beta and FSH-beta mRNA expression .
3044516	0	LH-releasing_hormone	45,65	LHRH	67,71	LH-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	The release of pituitary LH and sprouting of LH-releasing_hormone -LRB- LHRH -RRB- - containing neurons after anterior hypothalamic deafferentation .
393365	0	LH-releasing_hormone	59,79	LHRH	81,85	LH-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Effects of suprachiasmatic nucleus lesions on hypothalamic LH-releasing_hormone -LRB- LHRH -RRB- content and gonadotropin secretion in the ovariectomized -LRB- OVX -RRB- female rat .
16752389	0	LHFPL5	53,59	lipoma_HMGIC_fusion_partner-like_5	17,51	LHFPL5	lipoma HMGIC fusion partner-like 5	222662	222662	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the lipoma_HMGIC_fusion_partner-like_5 -LRB- LHFPL5 -RRB- gene cause autosomal_recessive_nonsyndromic_hearing_loss .
26025051	0	LHP1	65,69	BPC6	36,40	LHP1	BPC6	831635(Tax:3702)	834259(Tax:3702)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The Arabidopsis GAGA-binding factor BPC6 recruits PRC1 component LHP1 to GAGA DNA-motifs .
21193408	0	LHR	96,99	luteinizing_hormone_receptor	66,94	LHR	luteinizing hormone receptor	3973	3973	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Coactivator function of positive_cofactor_4 -LRB- PC4 -RRB- in Sp1-directed luteinizing_hormone_receptor -LRB- LHR -RRB- gene transcription .
23096696	0	LHR	48,51	luteinizing_hormone_receptor	18,46	LHR	luteinizing hormone receptor	101113228	101113228	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the luteinizing_hormone_receptor -LRB- LHR -RRB- gene in ovine non-gonadal tissues during estrous cycle .
23376535	0	LHR	45,48	luteinizing_hormone_receptor	15,43	LHR	luteinizing hormone receptor	3973	3973	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Association of luteinizing_hormone_receptor -LRB- LHR -RRB- mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies .
21193408	0	LHR	96,99	positive_cofactor_4	24,43	LHR	positive cofactor 4	3973	10923	Gene	Gene	gene|appos|START_ENTITY END_ENTITY|nmod|gene	Coactivator function of positive_cofactor_4 -LRB- PC4 -RRB- in Sp1-directed luteinizing_hormone_receptor -LRB- LHR -RRB- gene transcription .
8641215	0	LHRH	115,119	Basic_fibroblast_growth_factor	0,30	LHRH	Basic fibroblast growth factor	2796	2247	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor regulates the conversion of pro-luteinizing hormone-releasing hormone -LRB- Pro-LHRH -RRB- to LHRH in immortalized hypothalamic neurons .
3044516	0	LHRH	67,71	LH-releasing_hormone	45,65	LHRH	LH-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	The release of pituitary LH and sprouting of LH-releasing_hormone -LRB- LHRH -RRB- - containing neurons after anterior hypothalamic deafferentation .
393365	0	LHRH	81,85	LH-releasing_hormone	59,79	LHRH	LH-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Effects of suprachiasmatic nucleus lesions on hypothalamic LH-releasing_hormone -LRB- LHRH -RRB- content and gonadotropin secretion in the ovariectomized -LRB- OVX -RRB- female rat .
23418666	0	LHRH	39,43	Luteinizing_hormone-releasing_hormone	0,37	LHRH	Luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptor agonists vs antagonists : a matter of the receptors ?
9045998	0	LHRH	64,68	cFos	69,73	LHRH	cFos	25194(Tax:10116)	314322(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Alpha1-adrenergic receptor blockade blocks LH secretion but not LHRH cFos activation .
8886627	0	LHRH	11,15	follistatin	38,49	LHRH	follistatin	25194(Tax:10116)	24373(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of LHRH , FSH and activin_A on follistatin secretion from cultured rat anterior pituitary cells .
9627099	0	LHRH	14,18	interferon-gamma	36,52	LHRH	interferon-gamma	2796	3458	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	The effect of LHRH and TRH on human interferon-gamma production in vivo and in vitro .
12127507	0	LHRH	72,76	luteinizing_hormone-releasing_hormone	33,70	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	A new class of potent nonpeptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists : design and synthesis of 2-phenylimidazo -LSB- 1,2-a -RSB- pyrimidin-5-ones .
1493257	0	LHRH	62,66	luteinizing_hormone-releasing_hormone	23,60	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Behavioural effects of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in rats .
15006412	0	LHRH	94,98	luteinizing_hormone-releasing_hormone	55,92	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Elimination of antibacterial activities of non-peptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists derived from erythromycin_A .
15664860	0	LHRH	85,89	luteinizing_hormone-releasing_hormone	46,83	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Benzimidazole derivatives as novel nonpeptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists .
15664861	0	LHRH	85,89	luteinizing_hormone-releasing_hormone	46,83	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Benzimidazole derivatives as novel nonpeptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists .
15837306	0	LHRH	69,73	luteinizing_hormone-releasing_hormone	30,67	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Benzimidazoles as non-peptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists .
1661880	0	LHRH	75,79	luteinizing_hormone-releasing_hormone	36,73	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Content and distribution pattern of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the hypothalamus of neonatally estrogenized female rats .
17216287	0	LHRH	94,98	luteinizing_hormone-releasing_hormone	55,92	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	QSAR models for predicting the activity of non-peptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists derived from erythromycin_A using quantum chemical properties .
1740548	0	LHRH	74,78	luteinizing_hormone-releasing_hormone	35,72	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the nervus terminalis and brain of the big brown bat , Eptesicus fuscus .
1846575	0	LHRH	74,78	luteinizing_hormone-releasing_hormone	35,72	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Blockade of central and peripheral luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors in neonatal rats with a potent LHRH-antagonist inhibits the morphofunctional development of the thymus and maturation of the cell-mediated and humoral immune responses .
1999181	0	LHRH	51,55	luteinizing_hormone-releasing_hormone	12,49	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Presence of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- mRNA in rat spleen lymphocytes .
2436893	0	LHRH	138,142	luteinizing_hormone-releasing_hormone	67,104	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	replacement|nmod|START_ENTITY END_ENTITY|dep|replacement	Pulsatile follicle-stimulating hormone secretion is independent of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- : pulsatile replacement of LHRH bioactivity in LHRH-immunoneutralized rats .
3036261	0	LHRH	59,63	luteinizing_hormone-releasing_hormone	20,57	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Absence of specific luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors in the ovaries of Djungarian hamsters -LRB- Phodopus sungorus -RRB- .
3149759	0	LHRH	59,63	luteinizing_hormone-releasing_hormone	20,57	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- neurons and fibers in the Formosan rock-monkey .
3283711	0	LHRH	67,71	luteinizing_hormone-releasing_hormone	28,65	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Proteolytic inactivation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- by the whole rat ovary in vitro .
3511544	0	LHRH	50,54	luteinizing_hormone-releasing_hormone	6,43	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human luteinizing_hormone-releasing_hormone gene -LRB- LHRH -RRB- is located on short arm of chromosome 8 -LRB- region 8p11 .2 -- p21 -RRB- .
3512631	0	LHRH	74,78	luteinizing_hormone-releasing_hormone	35,72	LHRH	luteinizing hormone-releasing hormone	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- pathways in the sheep brain during anestrus and the mid-luteal phase of the estrous cycle .
405202	0	LHRH	59,63	luteinizing_hormone-releasing_hormone	20,57	LHRH	luteinizing hormone-releasing hormone	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the hypothalamus of the rhesus_monkey .
6092043	0	LHRH	114,118	luteinizing_hormone-releasing_hormone	75,112	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Maternal modulation of infantile ovarian development and available ovarian luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors via milk LHRH .
6166655	0	LHRH	74,78	luteinizing_hormone-releasing_hormone	35,72	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in Vibratome-sectioned brain .
6263596	0	LHRH	72,76	luteinizing_hormone-releasing_hormone	33,70	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Dissociated changes of pituitary luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors and responsiveness to the neurohormone induced by 17_beta-estradiol and LHRH in vivo in the rat .
6400339	0	LHRH	74,78	luteinizing_hormone-releasing_hormone	35,72	LHRH	luteinizing hormone-releasing hormone	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	An immunocytochemical study of the luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- system in the white-footed mouse : effect of blinding and melatonin .
7036108	0	LHRH	83,87	luteinizing_hormone-releasing_hormone	44,81	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence and localization of immunoreactive luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- within the olfactory bulbs of adult male and female rats .
7626711	0	LHRH	53,57	luteinizing_hormone-releasing_hormone	14,51	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- secretion by melatonin in the ewe .
7626716	0	LHRH	53,57	luteinizing_hormone-releasing_hormone	14,51	LHRH	luteinizing hormone-releasing hormone	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- secretion by melatonin in the ewe .
780101	0	LHRH	55,59	luteinizing_hormone-releasing_hormone	16,53	LHRH	luteinizing hormone-releasing hormone	100135531(Tax:10141)	100135531(Tax:10141)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the guinea_pig brain .
8778229	0	LHRH	90,94	luteinizing_hormone-releasing_hormone	51,88	LHRH	luteinizing hormone-releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The effect of castration on steady state levels of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- mRNA and proLHRH processing : time course study utilizing semi-quantitative reverse transcription/polymerase chain reaction .
9590126	0	LHRH	68,72	luteinizing_hormone-releasing_hormone	29,66	LHRH	luteinizing hormone-releasing hormone	2796	2796	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Growth-inhibitory effects of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- agonists on xenografts of the DU 145 human androgen-independent prostate_cancer cell line in nude_mice .
122596	0	LHRH	53,57	luteinizing_hormone_releasing_hormone	14,51	LHRH	luteinizing hormone releasing hormone	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- antiserum administration on gonadotropin secretion in the rhesus_monkey .
12384185	0	LHRH	64,68	luteinizing_hormone_releasing_hormone	25,62	LHRH	luteinizing hormone releasing hormone	2796	2796	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Enzymatic degradation of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- by mucosal homogenates from the intestine of the common_brushtail possum -LRB- Trichosurus_vulpecula -RRB- .
24014	0	LHRH	63,67	luteinizing_hormone_releasing_hormone	24,61	LHRH	luteinizing hormone releasing hormone	2796	2796	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Postnidatory effects of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- in hamsters .
3010923	0	LHRH	74,78	luteinizing_hormone_releasing_hormone	35,72	LHRH	luteinizing hormone releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Autoradiographical localization of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- receptors on rat testicular intertubular cells fractionated on Percoll density gradients .
3019631	0	LHRH	51,55	luteinizing_hormone_releasing_hormone	12,49	LHRH	luteinizing hormone releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- in milk .
3329439	0	LHRH	53,57	luteinizing_hormone_releasing_hormone	14,51	LHRH	luteinizing hormone releasing hormone	2796	2796	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- on steroidogenesis by the human luteal tissue .
6356168	0	LHRH	52,56	luteinizing_hormone_releasing_hormone	13,50	LHRH	luteinizing hormone releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- on the behavioral effects of amphetamine in rats .
7724042	0	LHRH	58,62	luteinizing_hormone_releasing_hormone	19,56	LHRH	luteinizing hormone releasing hormone	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Melatonin inhibits luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- induction of LH release from fetal rat pituitary cells .
8126131	0	LHRH	59,63	luteinizing_hormone_releasing_hormone	20,57	LHRH	luteinizing hormone releasing hormone	2796	2796	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Predictive value of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- bolus testing before and after 36-hour pulsatile LHRH administration in the differential diagnosis of constitutional_delay_of_puberty and male hypogonadotropic_hypogonadism .
18619506	0	LHRH-1	85,91	luteinizing_hormone_releasing_hormone	46,83	LHRH-1	luteinizing hormone releasing hormone	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Postmenopausal increase in KiSS-1 , GPR54 , and luteinizing_hormone_releasing_hormone -LRB- LHRH-1 -RRB- mRNA in the basal hypothalamus of female rhesus_monkeys .
26189214	0	LHX2	50,54	miR-1238	0,8	LHX2	miR-1238	9355	100302226	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-1238 inhibits cell proliferation by targeting LHX2 in non-small_cell_lung_cancer .
21965270	0	LHX4	50,54	alpha-fetoprotein	18,35	LHX4	alpha-fetoprotein	89884	174	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of alpha-fetoprotein expression by LHX4 : a critical role in hepatocarcinogenesis .
10903894	0	LHX_3	96,101	LIM-homeobox3	81,94	LHX 3	LIM-homeobox3	8022	8022	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure , chromosomal localization , and expression pattern of the human LIM-homeobox3 -LRB- LHX_3 -RRB- gene .
26125466	0	LH_Receptor	29,40	TNF-a	0,5	LH Receptor	TNF-a	25477(Tax:10116)	24835(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TNF-a Suppressed FSH-Induced LH_Receptor Expression Through Transcriptional Regulation in Rat Granulosa Cells .
26125464	0	LH_Receptor	18,29	miR-122	0,7	LH Receptor	miR-122	25477(Tax:10116)	100314023(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|amod|END_ENTITY	miR-122 Regulates LH_Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries .
11123515	0	LH_beta	81,88	FSH_beta	52,60	LH beta	FSH beta	16866(Tax:10090)	14308(Tax:10090)	Gene	Gene	that|nmod|START_ENTITY resemble|xcomp|that Manipulating|xcomp|resemble Manipulating|nmod|profile profile|nmod|END_ENTITY	Manipulating the in vivo mRNA expression profile of FSH_beta to resemble that of LH_beta does not promote a concomitant increase in intracellular storage of follicle-stimulating hormone .
9229355	0	LH_beta	31,38	FSH_beta	41,49	LH beta	FSH beta	3972	2488	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Ontogeny of growth_hormone and LH_beta - , FSH_beta - and alpha-subunit mRNA levels in the porcine fetal and neonatal anterior pituitary .
9179297	0	LH_receptor	104,115	HC11	119,123	LH receptor	HC11	3973	6347	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Recombinant expression and secretion of a natural splicing variant containing the ectodomain of porcine LH_receptor in HC11 mammary epithelial cells .
24064360	0	LH_receptor	14,25	miR-122	50,57	LH receptor	miR-122	25477(Tax:10116)	100314023(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY mRNA|nsubj|Regulation mRNA|advcl|END_ENTITY	Regulation of LH_receptor mRNA binding protein by miR-122 in rat ovaries .
189552	0	LH_receptor	118,129	prolactin	76,85	LH receptor	prolactin	25477(Tax:10116)	24683(Tax:10116)	Gene	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Localization of prolactin binding in prostate and testis : The role of serum prolactin concentration on the testicular LH_receptor .
19175184	0	LH_receptor	14,25	regulator_of_G_protein_signaling_2	66,100	LH receptor	regulator of G protein signaling 2	3973	5997	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of LH_receptor and PGF2alpha_receptor signaling by the regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- in human and mouse granulosa cells .
16530935	0	LHbeta	33,39	Egr-1	59,64	LHbeta	Egr-1	16866(Tax:10090)	13653(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Insulin augments GnRH-stimulated LHbeta gene expression by Egr-1 .
20430510	0	LHbeta	39,45	Luteinizing_hormone_beta-subunit	0,32	LHbeta	Luteinizing hormone beta-subunit	3972	3972	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Luteinizing_hormone_beta-subunit gene -LRB- LHbeta -RRB- polymorphism in infertility and endometriosis-associated infertility .
16087728	0	LHbeta	44,50	Pituitary_homeobox_1	0,20	LHbeta	Pituitary homeobox 1	25329(Tax:10116)	113983(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Pituitary_homeobox_1 -LRB- Pitx1 -RRB- stimulates rat LHbeta gene expression via two functional DNA-regulatory regions .
25078593	0	LIAS	48,52	lipoic_acid_synthase	26,46	LIAS	lipoic acid synthase	100627627	100627627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the porcine lipoic_acid_synthase -LRB- LIAS -RRB- gene in Escherichia_coli .
10486560	0	LIF	38,41	BMP2	62,66	LIF	BMP2	16878(Tax:10090)	12156(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Astrocyte differentiation mediated by LIF in cooperation with BMP2 .
16797728	0	LIF	47,50	IFN-beta	11,19	LIF	IFN-beta	3976	3456	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of IFN-beta , leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls .
133010	0	LIF	39,42	Leucocyte_migration_inhibition_factor	0,37	LIF	Leucocyte migration inhibition factor	3976	3976	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Leucocyte_migration_inhibition_factor -LRB- LIF -RRB- production by lymphocytes of normal children , newborns , and children with immune_deficiency .
17392578	0	LIF	0,3	NK-1R	30,35	LIF	NK-1R	3976	6869	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	LIF upregulates expression of NK-1R in NHBE cells .
7540557	0	LIF	78,81	SCF	41,44	LIF	SCF	16878(Tax:10090)	17311(Tax:10090)	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	Hematologic effects of stem_cell_factor -LRB- SCF -RRB- and leukemia_inhibitory_factor -LRB- LIF -RRB- in vivo : LIF-induced thrombocytosis in SCF-primed mice .
16497512	0	LIF	27,30	SOCS3	0,5	LIF	SOCS3	3976	9021	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SOCS3 negatively regulates LIF signaling in neural precursor cells .
12372629	0	LIF	41,44	Thrombopoietin	0,14	LIF	Thrombopoietin	16878(Tax:10090)	21832(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic_stem cells homozygous for a Shp-2 deletion mutation .
20564184	0	LIF	36,39	Tumor_necrosis_factor_alpha	0,27	LIF	Tumor necrosis factor alpha	3976	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells .
25378661	0	LIF	38,41	calreticulin	15,27	LIF	calreticulin	3976	811	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells .
639351	0	LIF	53,56	leucocyte_migration_inhibitory_factor	14,51	LIF	leucocyte migration inhibitory factor	3976	3976	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of leucocyte_migration_inhibitory_factor -LRB- LIF -RRB- in infectious_mononucleosis .
7032773	0	LIF	52,55	leucocyte_migration_inhibitory_factor	13,50	LIF	leucocyte migration inhibitory factor	100713602	100713602	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of leucocyte_migration_inhibitory_factor -LRB- LIF -RRB- by stimulation with free hapten and water-insoluble epoxy resin .
10704254	0	LIF	48,51	leukaemia_inhibitory_factor	19,46	LIF	leukaemia inhibitory factor	3976	3976	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Renal synthesis of leukaemia_inhibitory_factor -LRB- LIF -RRB- , under normal and inflammatory conditions .
11349461	0	LIF	38,41	leukaemia_inhibitory_factor	9,36	LIF	leukaemia inhibitory factor	3976	3976	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Elevated leukaemia_inhibitory_factor -LRB- LIF -RRB- expression in lesional psoriatic skin : correlation with interleukin _ -LRB- IL -RRB- -8 expression .
11756390	0	LIF	46,49	leukaemia_inhibitory_factor	17,44	LIF	leukaemia inhibitory factor	3976	3976	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of leukaemia_inhibitory_factor -LRB- LIF -RRB- in uterine flushing fluid is highly predictive of embryo implantation .
1425017	0	LIF	61,64	leukaemia_inhibitory_factor	32,59	LIF	leukaemia inhibitory factor	3976	3976	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Reconstitution of high affinity leukaemia_inhibitory_factor -LRB- LIF -RRB- receptors in haemopoietic cells transfected with the cloned human LIF_receptor .
1461995	0	LIF	43,46	leukaemia_inhibitory_factor	14,41	LIF	leukaemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of leukaemia_inhibitory_factor -LRB- LIF -RRB- on embryogenesis .
16024536	0	LIF	77,80	leukaemia_inhibitory_factor	48,75	LIF	leukaemia inhibitory factor	3976	3976	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Removal of hydrosalpinges increases endometrial leukaemia_inhibitory_factor -LRB- LIF -RRB- expression at the time of the implantation window .
8568779	0	LIF	56,59	leukaemia_inhibitory_factor	27,54	LIF	leukaemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Trophic effects of myeloid leukaemia_inhibitory_factor -LRB- LIF -RRB- on mouse embryos .
8572536	0	LIF	37,40	leukaemia_inhibitory_factor	8,35	LIF	leukaemia inhibitory factor	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of leukaemia_inhibitory_factor -LRB- LIF -RRB- in rat peripheral nerve regeneration .
9124702	0	LIF	68,71	leukaemia_inhibitory_factor	39,66	LIF	leukaemia inhibitory factor	280840(Tax:9913)	280840(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic characterization of the bovine leukaemia_inhibitory_factor -LRB- LIF -RRB- gene : isolation and sequencing , chromosome assignment and microsatellite analysis .
9401818	0	LIF	51,54	leukaemia_inhibitory_factor	22,49	LIF	leukaemia inhibitory factor	3976	3976	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Controlled release of leukaemia_inhibitory_factor -LRB- LIF -RRB- to tissues .
11587067	0	LIF	136,139	leukemia_inhibitory_factor	108,134	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia_inhibitory_factor -LRB- LIF -RRB- gene .
14673505	0	LIF	98,101	leukemia_inhibitory_factor	66,92	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Cloning , eukaryotic expression and function assay of recombinant leukemia_inhibitory_factor gene LIF -RSB- .
14970834	0	LIF	111,114	leukemia_inhibitory_factor	83,109	LIF	leukemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia_inhibitory_factor -LRB- LIF -RRB- gene .
1561703	0	LIF	55,58	leukemia_inhibitory_factor	27,53	LIF	leukemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive expression of leukemia_inhibitory_factor -LRB- LIF -RRB- mRNA and production of LIF by a cloned murine thymic stromal cell line .
15685635	0	LIF	38,41	leukemia_inhibitory_factor	10,36	LIF	leukemia inhibitory factor	280840(Tax:9913)	280840(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of leukemia_inhibitory_factor -LRB- LIF -RRB- on in vitro produced bovine embryos and their outgrowth colonies .
15889014	0	LIF	53,56	leukemia_inhibitory_factor	25,51	LIF	leukemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Transgenic expression of leukemia_inhibitory_factor -LRB- LIF -RRB- blocks normal vascular development but not pathological neovascularization in the eye .
18672620	0	LIF	38,41	leukemia_inhibitory_factor	10,36	LIF	leukemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of leukemia_inhibitory_factor -LRB- LIF -RRB- on the quality of in vitro produced mouse blastocysts and subsequent derivation of embryonic stem -LRB- ES -RRB- cells .
1950765	0	LIF	39,42	leukemia_inhibitory_factor	11,37	LIF	leukemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of leukemia_inhibitory_factor -LRB- LIF -RRB- on gene transfer efficiency into murine hematolymphoid progenitors .
21191816	0	LIF	56,59	leukemia_inhibitory_factor	28,54	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Epigenetic up-regulation of leukemia_inhibitory_factor -LRB- LIF -RRB- gene during the progression to breast_cancer .
21613225	0	LIF	65,68	leukemia_inhibitory_factor	37,63	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Extensive mannose phosphorylation on leukemia_inhibitory_factor -LRB- LIF -RRB- controls its extracellular levels by multiple mechanisms .
21729793	0	LIF	42,45	leukemia_inhibitory_factor	14,40	LIF	leukemia inhibitory factor	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of leukemia_inhibitory_factor -LRB- LIF -RRB- in a rat model of postoperative_pain .
23628981	0	LIF	121,124	leukemia_inhibitory_factor	93,119	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High-level expression and efficient one-step chromatographic purification of a soluble human leukemia_inhibitory_factor -LRB- LIF -RRB- in Escherichia_coli .
23831429	0	LIF	10,13	leukemia_inhibitory_factor	15,41	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Impact of LIF -LRB- leukemia_inhibitory_factor -RRB- expression in malignant_melanoma .
2491897	0	LIF	47,50	leukemia_inhibitory_factor	19,45	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for human leukemia_inhibitory_factor -LRB- LIF -RRB- maps to 22q12 .
25162623	0	LIF	44,47	leukemia_inhibitory_factor	16,42	LIF	leukemia inhibitory factor	555717(Tax:7955)	555717(Tax:7955)	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of leukemia_inhibitory_factor -LRB- LIF -RRB- during the early stage of optic nerve regeneration in zebrafish .
7999791	0	LIF	59,62	leukemia_inhibitory_factor	31,57	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High level expression of human leukemia_inhibitory_factor -LRB- LIF -RRB- from a synthetic gene in Escherichia_coli and the physical and biological characterization of the protein .
8260605	0	LIF	123,126	leukemia_inhibitory_factor	95,121	LIF	leukemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Delineation of positive and negative control elements within the promoter region of the murine leukemia_inhibitory_factor -LRB- LIF -RRB- gene .
8770940	0	LIF	45,48	leukemia_inhibitory_factor	17,43	LIF	leukemia inhibitory factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Disrupted murine leukemia_inhibitory_factor -LRB- LIF -RRB- gene attenuates adrenocorticotropic_hormone -LRB- ACTH -RRB- secretion .
8899749	0	LIF	51,54	leukemia_inhibitory_factor	23,49	LIF	leukemia inhibitory factor	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Neuronal expression of leukemia_inhibitory_factor -LRB- LIF -RRB- in the rat brain .
9052938	0	LIF	64,67	leukemia_inhibitory_factor	36,62	LIF	leukemia inhibitory factor	100358914(Tax:9986)	100358914(Tax:9986)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential hormonal regulation of leukemia_inhibitory_factor -LRB- LIF -RRB- in rabbit and mouse uterus .
9151079	0	LIF	41,44	leukemia_inhibitory_factor	13,39	LIF	leukemia inhibitory factor	3976	3976	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of leukemia_inhibitory_factor -LRB- LIF -RRB- on the survival , proliferation and differentiation of human erythroid progenitor cells .
9666105	0	LIF	38,41	leukemia_inhibitory_factor	10,36	LIF	leukemia inhibitory factor	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of leukemia_inhibitory_factor -LRB- LIF -RRB- on the morphology and survival of cultured hippocampal neurons and glial cells .
618069	0	LIF	57,60	leukocyte_inhibiting_factor	28,55	LIF	leukocyte inhibiting factor	3976	3976	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	The effect of levamisole on leukocyte_inhibiting_factor -LRB- LIF -RRB- production `` in vitro '' .
3027180	0	LIF	40,43	leukocyte_inhibitory_factor	11,38	LIF	leukocyte inhibitory factor	3976	3976	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of leukocyte_inhibitory_factor -LRB- LIF -RRB- on neutrophil mediated antibody-dependent_cellular_cytotoxicity .
6305834	0	LIF	40,43	leukocyte_inhibitory_factor	11,38	LIF	leukocyte inhibitory factor	3976	3976	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of leukocyte_inhibitory_factor -LRB- LIF -RRB- on human neutrophil function .
852151	0	LIF	43,46	leukocyte_inhibitory_factor	14,41	LIF	leukocyte inhibitory factor	3976	3976	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of leukocyte_inhibitory_factor -LRB- LIF -RRB- in Hodgkin 's _ disease .
1106109	0	LIF	59,62	leukocyte_migration_inhibitory_factor	20,57	LIF	leukocyte migration inhibitory factor	3976	3976	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human leukocyte_migration_inhibitory_factor -LRB- LIF -RRB- by alpha-L-fucose .
18046411	0	LIF	44,47	p53	0,3	LIF	p53	16878(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p53 regulates maternal reproduction through LIF .
19907922	0	LIF	14,17	p53	0,3	LIF	p53	3976	7157	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	p53 Regulates LIF expression in human medulloblastoma cells .
25323535	0	LIF	0,3	p53	43,46	LIF	p53	3976	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal_cancers .
26161442	0	LIF	0,3	p53	13,16	LIF	p53	3976	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|compound|END_ENTITY	LIF is a new p53 negative regulator .
25165882	0	LIF	0,3	poFUT1	16,22	LIF	poFUT1	3976	23509	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface .
15372367	0	LIF-R	58,63	leukemia_inhibitory_factor-receptor	21,56	LIF-R	leukemia inhibitory factor-receptor	3977	3977	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Mutation analysis of leukemia_inhibitory_factor-receptor -LRB- LIF-R -RRB- in ACTH-secreting pituitary_adenomas .
1542794	0	LIF_receptor	91,103	oncostatin_M	38,50	LIF receptor	oncostatin M	3977	5008	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
23238213	0	LILRA3	20,26	ILT6	28,32	LILRA3	ILT6	11026	11026	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	6.7-kbp deletion in LILRA3 -LRB- ILT6 -RRB- gene is associated with later onset of the multiple_sclerosis in a Polish population .
26969150	0	LILRA3	19,25	TLR8	0,4	LILRA3	TLR8	11026	51311	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency_virus_infection and correlates to CD4 counts and virus loads .
24906639	0	LILRA3	57,63	leucocyte_immunoglobulin-like_receptor_A3	14,55	LILRA3	leucocyte immunoglobulin-like receptor A3	11026	11026	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of the leucocyte_immunoglobulin-like_receptor_A3 -LRB- LILRA3 -RRB- on susceptibility and subphenotypes of systemic_lupus_erythematosus and Sj gren 's syndrome .
17549736	0	LILRB1	98,104	HLA-G	25,30	LILRB1	HLA-G	10859	3135	Gene	Gene	antigen-presenting_cells|nmod|START_ENTITY modulates|dobj|antigen-presenting_cells modulates|nsubj|complex complex|nmod|END_ENTITY	A homodimeric complex of HLA-G on normal trophoblast cells modulates antigen-presenting_cells via LILRB1 .
25853899	0	LILRB1	73,79	HLA-G	64,69	LILRB1	HLA-G	10859	3135	Gene	Gene	Receptor|compound|START_ENTITY END_ENTITY|nmod|Receptor	The Paradox of High Availability and Low Recognition of Soluble HLA-G by LILRB1 Receptor in Rheumatoid_Arthritis Patients .
26769854	0	LILRB3	31,37	cytokeratin_8	54,67	LILRB3	cytokeratin 8	11025	3856	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin_8 - associated ligand on necrotic glandular epithelial cells .
11029037	0	LIM	19,22	Ajuba	0,5	LIM	Ajuba	56376(Tax:10090)	16475(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Ajuba , a cytosolic LIM protein , shuttles into the nucleus and affects embryonal cell proliferation and fate decisions .
15706082	0	LIM	104,107	Hic-5	117,122	LIM	Hic-5	10611	7041	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Involvement of FAK and PTP-PEST in the regulation of redox-sensitive nuclear-cytoplasmic shuttling of a LIM protein , Hic-5 .
18762808	0	LIM	68,71	Hic-5	80,85	LIM	Hic-5	10611	7041	Gene	Gene	ARA55|compound|START_ENTITY ARA55|compound|END_ENTITY	Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5 / ARA55 .
9286712	0	LIM	8,11	Lhx4	0,4	LIM	Lhx4	56376(Tax:10090)	16872(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Lhx4 , a LIM homeobox gene .
9417918	0	LIM	35,38	Limatin	0,7	LIM	Limatin	10611	3983	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Limatin -LRB- LIMAB1 -RRB- , an actin-binding LIM protein , maps to mouse chromosome 19 and human chromosome 10q25 , a region frequently deleted in human cancers .
16044170	0	LIM	44,47	PDLIM5	49,55	LIM	PDLIM5	10611	10611	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression and association analyses of LIM -LRB- PDLIM5 -RRB- in bipolar_disorder and schizophrenia .
16595163	0	LIM	44,47	PDLIM5	49,55	LIM	PDLIM5	10611	10611	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression and association analysis of LIM -LRB- PDLIM5 -RRB- in major_depression .
17332327	0	LIM	7,10	RIL	0,3	LIM	RIL	10611	8572	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	RIL , a LIM gene on 5q31 , is silenced by methylation in cancer and sensitizes cancer cells to apoptosis .
7590899	0	LIM	80,83	TGF-beta	10,18	LIM	TGF-beta	10611	7040	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of TGF-beta on differentiated organoids of the colon_carcinoma cell line LIM 1863 .
9664039	0	LIM	19,22	hic-5	31,36	LIM	hic-5	10611	7041	Gene	Gene	protein|compound|START_ENTITY Recruitment|nmod|protein Recruitment|amod|END_ENTITY	Recruitment of the LIM protein hic-5 to focal contacts of human platelets .
10903894	0	LIM-homeobox3	81,94	LHX_3	96,101	LIM-homeobox3	LHX 3	8022	8022	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure , chromosomal localization , and expression pattern of the human LIM-homeobox3 -LRB- LHX_3 -RRB- gene .
14530263	0	LIM-kinase_1	62,74	p57Kip2	0,7	LIM-kinase 1	p57Kip2	16885(Tax:10090)	12577(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase_1 to the nucleus .
18677772	0	LIM-nebulette	22,35	LASP2	37,42	LIM-nebulette	LASP2	10529	10529	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Ectopic expression of LIM-nebulette -LRB- LASP2 -RRB- reveals roles in cell migration and spreading .
9724756	0	LIM-only	15,23	dLMO	30,34	LIM-only	dLMO	32846(Tax:7227)	32846(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Drosophila LIM-only gene , dLMO , is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development .
7789634	0	LIM/homeodomain	24,39	islet-1	45,52	LIM/homeodomain	islet-1	10611	3670	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM .
10623575	0	LIM1	29,33	OTX2	0,4	LIM1	OTX2	16869(Tax:10090)	18424(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	OTX2 directly interacts with LIM1 and HNF-3beta .
15968979	0	LIM2	135,139	MP19	124,128	LIM2	MP19	3982	3982	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Identification of a lens-specific cis-acting element within the basal promoter of the human lens intrinsic membrane protein MP19 gene -LRB- LIM2 -RRB- .
8922390	0	LIM3	18,22	vinculin	152,160	LIM3	vinculin	8022	7414	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal_adhesion_kinase binding .
15538389	0	LIMK1	14,19	BMP	38,41	LIMK1	BMP	3984	649	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|binding binding|nmod|END_ENTITY	Activation of LIMK1 by binding to the BMP receptor , BMPRII , regulates BMP-dependent dendritogenesis .
15538389	0	LIMK1	14,19	BMPRII	52,58	LIMK1	BMPRII	3984	659	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of LIMK1 by binding to the BMP receptor , BMPRII , regulates BMP-dependent dendritogenesis .
25019203	0	LIMK1	102,107	MiR-20a	0,7	LIMK1	MiR-20a	3984	406982	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-20a inhibits cutaneous_squamous_cell_carcinoma metastasis and proliferation by directly targeting LIMK1 .
24390089	0	LIMK1	16,21	MiR-27b	0,7	LIMK1	MiR-27b	3984	407019	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MiR-27b targets LIMK1 to inhibit growth and invasion of NSCLC cells .
23082153	0	LIMK2	25,30	Nf1	0,3	LIMK2	Nf1	3985	4763	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways .
23082153	0	LIMK2	25,30	RasGAP	4,10	LIMK2	RasGAP	3985	5921	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways .
17512523	0	LIM_Kinase_1	22,34	Parkin	0,6	LIM Kinase 1	Parkin	3984	5071	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Parkin interacts with LIM_Kinase_1 and reduces its cofilin-phosphorylation activity via ubiquitination .
22897902	0	LIM_and_SH3_protein_1	50,71	LASP-1	73,79	LIM and SH3 protein 1	LASP-1	3927	3927	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Role of hepatitis_B virus X protein in regulating LIM_and_SH3_protein_1 -LRB- LASP-1 -RRB- expression to mediate proliferation and migration of hepatoma cells .
20924110	0	LIM_and_SH3_protein_1	8,29	LASP1	31,36	LIM and SH3 protein 1	LASP1	3927;10611	3927	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of LIM_and_SH3_protein_1 -LRB- LASP1 -RRB- in the metastatic dissemination of medulloblastoma .
22222369	0	LIM_domain_only_2	101,118	Lmo2	120,124	LIM domain only 2	Lmo2	4005	4005	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Nuclear localization of lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- and its role in regulating LIM_domain_only_2 -LRB- Lmo2 -RRB- gene .
22241179	0	LIM_domain_protein-3	0,20	BMP7	44,48	LIM domain protein-3	BMP7	9260	655	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	LIM_domain_protein-3 -LRB- LMP3 -RRB- cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells .
18332102	0	LIM_kinase	19,29	Nischarin	0,9	LIM kinase	Nischarin	3984	11188	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Nischarin inhibits LIM_kinase to regulate cofilin phosphorylation and cell invasion .
16230460	0	LIM_kinase	55,65	cofilin	35,42	LIM kinase	cofilin	3984	1072	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Spatial and temporal regulation of cofilin activity by LIM_kinase and Slingshot is critical for directional cell migration .
18096821	0	LIM_kinase	39,49	cofilin	19,26	LIM kinase	cofilin	3984	1072	Gene	Gene	phosphatase|compound|START_ENTITY activity|nmod|phosphatase activity|compound|END_ENTITY	Dual regulation of cofilin activity by LIM_kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells .
18332102	0	LIM_kinase	19,29	cofilin	42,49	LIM kinase	cofilin	3984	1072	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|xcomp|regulate regulate|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Nischarin inhibits LIM_kinase to regulate cofilin phosphorylation and cell invasion .
16204183	0	LIM_kinase_1	42,54	Rnf6	21,25	LIM kinase 1	Rnf6	16885(Tax:10090)	74132(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	The ubiquitin ligase Rnf6 regulates local LIM_kinase_1 levels in axonal growth cones .
14684741	0	LIM_kinase_1	0,12	cAMP-responsive_element-binding_protein	23,62	LIM kinase 1	cAMP-responsive element-binding protein	3984	1385	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	LIM_kinase_1 activates cAMP-responsive_element-binding_protein during the neuronal differentiation of immortalized hippocampal progenitor cells .
24247826	0	LIM_kinase_1	0,12	insulin	29,36	LIM kinase 1	insulin	3984	3630	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	LIM_kinase_1 is required for insulin - dependent cell growth of osteosarcoma cell lines .
23086941	0	LIM_kinase_1	0,12	tropomyosin-related_kinase_B	36,64	LIM kinase 1	tropomyosin-related kinase B	3984	4915	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LIM_kinase_1 -LRB- LIMK1 -RRB- interacts with tropomyosin-related_kinase_B -LRB- TrkB -RRB- and Mediates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced axonal elongation .
9753323	0	LIN-10	16,22	LIN-2	4,9	LIN-10	LIN-2	172597(Tax:6239)	181400(Tax:6239)	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	The LIN-2 / LIN-7 / LIN-10 complex mediates basolateral membrane localization of the C. _ elegans EGF receptor LET-23 in vulval epithelial cells .
20951046	0	LIN-12	21,27	LIN-14	0,6	LIN-12	LIN-14	176282(Tax:6239)	181337(Tax:6239)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	LIN-14 inhibition of LIN-12 contributes to precision and timing of C. _ elegans vulval fate patterning .
18050403	0	LIN-12	0,6	Notch	7,12	LIN-12	Notch	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	START_ENTITY|appos|signaling signaling|nsubj|END_ENTITY	LIN-12 / Notch signaling in C. _ elegans .
23483278	0	LIN-12	0,6	Notch	7,12	LIN-12	Notch	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	LIN-12 / Notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification .
24512688	0	LIN-12	14,20	Notch	21,26	LIN-12	Notch	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	A role of the LIN-12 / Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. _ elegans .
9442877	0	LIN-12	4,10	Notch	11,16	LIN-12	Notch	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	The LIN-12 / Notch signaling pathway and its regulation .
9043078	0	LIN-12	70,76	SEL-1	39,44	LIN-12	SEL-1	176282(Tax:6239)	179720(Tax:6239)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Structure , function , and expression of SEL-1 , a negative regulator of LIN-12 and GLP-1 in C. _ elegans .
11784090	0	LIN-12	29,35	nicastrin	6,15	LIN-12	nicastrin	176282(Tax:6239)	172905(Tax:6239)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	APH-2 / nicastrin functions in LIN-12 / Notch signaling in the Caenorhabditis_elegans somatic gonad .
20951046	0	LIN-14	0,6	LIN-12	21,27	LIN-14	LIN-12	181337(Tax:6239)	176282(Tax:6239)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	LIN-14 inhibition of LIN-12 contributes to precision and timing of C. _ elegans vulval fate patterning .
10642801	0	LIN-14	93,99	lin-4	4,9	LIN-14	lin-4	181337(Tax:6239)	266860(Tax:6239)	Gene	Gene	synthesis|compound|START_ENTITY blocking|dobj|synthesis controls|advcl|blocking controls|nsubj|RNA RNA|amod|END_ENTITY	The lin-4 regulatory RNA controls developmental timing in Caenorhabditis_elegans by blocking LIN-14 protein synthesis after the initiation of translation .
22692424	0	LIN-14	31,37	lin-4	4,9	LIN-14	lin-4	181337(Tax:6239)	266860(Tax:6239)	Gene	Gene	factor|compound|START_ENTITY targets|dobj|factor targets|nsubj|microRNA microRNA|amod|END_ENTITY	The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction .
9753323	0	LIN-2	4,9	LIN-10	16,22	LIN-2	LIN-10	181400(Tax:6239)	172597(Tax:6239)	Gene	Gene	START_ENTITY|amod|complex complex|amod|END_ENTITY	The LIN-2 / LIN-7 / LIN-10 complex mediates basolateral membrane localization of the C. _ elegans EGF receptor LET-23 in vulval epithelial cells .
25805859	0	LIN-28	21,27	let-7	42,47	LIN-28	let-7	172626(Tax:6239)	266952(Tax:6239)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. _ elegans .
23154983	0	LIN-45	54,60	SEL-10	0,6	LIN-45	SEL-10	177436(Tax:6239)	179878(Tax:6239)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	SEL-10 / Fbw7-dependent negative feedback regulation of LIN-45 / Braf signaling in C. _ elegans via a conserved phosphodegron .
18286632	0	LIN-7	66,71	LIN-7	81,86	LIN-7	LIN-7	8825	8825	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association study of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and LIN-7 homolog -LRB- LIN-7 -RRB- genes with adult attention-deficit/hyperactivity _ disorder .
18286632	0	LIN-7	81,86	LIN-7	66,71	LIN-7	LIN-7	8825	8825	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Association study of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and LIN-7 homolog -LRB- LIN-7 -RRB- genes with adult attention-deficit/hyperactivity _ disorder .
22162396	0	LIN28	41,46	L1TD1	20,25	LIN28	L1TD1	79727	54596	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation .
25479749	0	LIN28A	46,52	SET7/9	0,6	LIN28A	SET7/9	79727	80854	Gene	Gene	Methylation|nmod|START_ENTITY Methylation|compound|END_ENTITY	SET7/9 Methylation of the Pluripotency Factor LIN28A Is a Nucleolar Localization Mechanism that Blocks let-7 Biogenesis in Human ESCs .
25368430	0	LIN28B	19,25	HMGA2	36,41	LIN28B	HMGA2	389421	8091	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	MUC1-C Induces the LIN28B > LET-7 > HMGA2 Axis to Regulate Self-Renewal in NSCLC .
26609473	0	LIN28B	0,6	let-7b	27,33	LIN28B	let-7b	389421	406884	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	LIN28B suppresses microRNA let-7b expression to promote CD44 + / LIN28B + human pancreatic_cancer stem cell proliferation and invasion .
17237226	0	LIN7	65,69	MPP7	28,32	LIN7	MPP7	8825	143098	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions .
23667535	0	LIN9	0,4	DREAM	23,28	LIN9	DREAM	286826	30818	Gene	Gene	START_ENTITY|appos|subunit subunit|nmod|complex complex|compound|END_ENTITY	LIN9 , a subunit of the DREAM complex , regulates mitotic gene expression and proliferation of embryonic stem cells .
26540343	0	LINC00152	0,9	EpCAM	74,79	LINC00152	EpCAM	112597	4072	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	LINC00152 promotes proliferation in hepatocellular_carcinoma by targeting EpCAM via the mTOR signaling pathway .
26546150	0	LINGO-1	14,21	Trk	43,46	LINGO-1	Trk	315691(Tax:10116)	59109(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptor receptor|compound|END_ENTITY	Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling .
20377621	0	LINGO-1	0,7	TrkB	29,33	LINGO-1	TrkB	84894	4915	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	LINGO-1 negatively regulates TrkB phosphorylation after ocular_hypertension .
19363035	0	LINGO-1	0,7	WNK1	23,27	LINGO-1	WNK1	84894	65125	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension .
25758563	0	LINGO-1	0,7	amyloid-b_protein_precursor	42,69	LINGO-1	amyloid-b protein precursor	84894	351	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	LINGO-1 promotes lysosomal degradation of amyloid-b_protein_precursor .
26017382	0	LIP	64,67	C/EBP	79,84	LIP	C/EBP	23049	1050	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	Degradation of polyomavirus_JC T-antigen by stress involves the LIP isoform of C/EBP .
15592826	0	LIP1	43,47	LIP1	91,95	LIP1	LIP1	855344(Tax:4932)	855344(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Multiple mutagenesis of the Candida rugosa LIP1 gene and optimum production of recombinant LIP1 expressed in Pichia_pastoris .
15592826	0	LIP1	91,95	LIP1	43,47	LIP1	LIP1	855344(Tax:4932)	855344(Tax:4932)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Multiple mutagenesis of the Candida rugosa LIP1 gene and optimum production of recombinant LIP1 expressed in Pichia_pastoris .
19357255	0	LIP5	0,4	aquaporin_2	20,31	LIP5	aquaporin 2	66201(Tax:10090)	11827(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LIP5 interacts with aquaporin_2 and facilitates its lysosomal degradation .
25620107	0	LIPA	80,84	lysosomal_acid_lipase	52,73	LIPA	lysosomal acid lipase	3988	3988	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression and functional characterization of human lysosomal_acid_lipase gene -LRB- LIPA -RRB- mutation responsible for cholesteryl_ester_storage_disease -LRB- CESD -RRB- phenotype .
8020990	0	LIPA	62,66	lysosomal_acid_lipase	34,55	LIPA	lysosomal acid lipase	3988	3988	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the human lysosomal_acid_lipase gene -LRB- LIPA -RRB- .
25550127	0	LIPC	16,20	Hepatic_lipase	0,14	LIPC	Hepatic lipase	3990	3990	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Hepatic_lipase -LRB- LIPC -RRB- C-514T gene polymorphism is associated with cardiometabolic parameters and cardiovascular risk factors but not with fatty_liver in Mexican population .
20385826	0	LIPC	121,125	hepatic_lipase	100,114	LIPC	hepatic lipase	3990	3990	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genome-wide association study of advanced age-related_macular_degeneration identifies a role of the hepatic_lipase gene -LRB- LIPC -RRB- .
9469601	0	LIPC	149,153	hepatic_lipase	128,142	LIPC	hepatic lipase	3990	3990	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hepatic_lipase activity is lower in African American men than in white American men : effects of 5 ' flanking polymorphism in the hepatic_lipase gene -LRB- LIPC -RRB- .
9684756	0	LIPC	50,54	hepatic_lipase	29,43	LIPC	hepatic lipase	3990	3990	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The -514 polymorphism in the hepatic_lipase gene -LRB- LIPC -RRB- does not influence androgen-mediated stimulation of hepatic_lipase activity .
14984737	0	LIPG	79,83	endothelial_lipase	59,77	LIPG	endothelial lipase	9388	9388	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between single-nucleotide polymorphisms in the endothelial_lipase -LRB- LIPG -RRB- gene and high-density lipoprotein cholesterol levels .
17333281	0	LIPH	28,32	lipase_H	18,26	LIPH	lipase H	200879	200879	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A mutation in the lipase_H -LRB- LIPH -RRB- gene underlie autosomal recessive hypotrichosis .
19167195	0	LIPH	38,42	lipase_H	28,36	LIPH	lipase H	200879	200879	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel missense mutations in lipase_H -LRB- LIPH -RRB- gene causing autosomal_recessive_hypotrichosis -LRB- LAH2 -RRB- .
26314621	0	LIR-1	96,101	CD8	102,105	LIR-1	CD8	10859	925	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Latent Cytomegalovirus_Infection in Rheumatoid_Arthritis and Increased Frequencies of Cytolytic LIR-1 + CD8 + T Cells .
11410407	0	LIR-1	29,34	ILT2	23,27	LIR-1	ILT2	10859	10859	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	High expression of the ILT2 -LRB- LIR-1 -RRB- inhibitory receptor for major histocompatibility complex class I molecules on clonal expansions of T large granular lymphocytes in asymptomatic patients .
12390682	0	LIR-1	61,66	UL18	160,164	LIR-1	UL18	10859	3077466(Tax:10359)	Gene	Gene	START_ENTITY|nmod|regions regions|acl|implicated implicated|nmod|the the|acl:relcl|MHC MHC|xcomp|homolog homolog|dobj|END_ENTITY	Crystal structure of LIR-2 -LRB- ILT4 -RRB- at 1.8 A : differences from LIR-1 -LRB- ILT2 -RRB- in regions implicated in the binding of the Human_Cytomegalovirus class I MHC homolog UL18 .
17372005	0	LIR-1	60,65	UL18	46,50	LIR-1	UL18	10859	3077466(Tax:10359)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The human_cytomegalovirus MHC class I homolog UL18 inhibits LIR-1 + but activates LIR-1 - NK cells .
8804025	0	LIS-1	48,53	lissencephaly_gene_1	26,46	LIS-1	lissencephaly gene 1	5048	5048	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Molecular analysis of the lissencephaly_gene_1 -LRB- LIS-1 -RRB- in medulloblastomas .
11163260	0	LIS1	53,57	Cdk5	17,21	LIS1	Cdk5	5048	1020	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein .
8038180	0	LIS1	13,17	ERG6	19,23	LIS1	ERG6	855003(Tax:4932)	855003(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in LIS1 -LRB- ERG6 -RRB- gene confer increased sodium and lithium uptake in Saccharomyces_cerevisiae .
15572112	0	LIS1	58,62	PAF-acetylhydrolase	79,98	LIS1	PAF-acetylhydrolase	5048	7941	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Coupling PAF signaling to dynein regulation : structure of LIS1 in complex with PAF-acetylhydrolase .
11754098	0	LIS1	74,78	PAFAH1B1	85,93	LIS1	PAFAH1B1	5048	5048	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Clinical and molecular basis of classical lissencephaly : Mutations in the LIS1 gene -LRB- PAFAH1B1 -RRB- .
20846927	0	LIS1	154,158	PAFAH1B1	144,152	LIS1	PAFAH1B1	5048	5048	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An isolated case of lissencephaly caused by the insertion of a mitochondrial genome-derived DNA sequence into the 5 ' untranslated region of the PAFAH1B1 -LRB- LIS1 -RRB- gene .
21595003	0	LIS1	70,74	PAFAH1B1	60,68	LIS1	PAFAH1B1	5048	5048	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A microduplication on chromosome 17p13 .1 p13 .3 including the PAFAH1B1 -LRB- LIS1 -RRB- gene .
10940388	0	LIS1	22,26	rNUDE	129,134	LIS1	rNUDE	5048	83836(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	Direct association of LIS1 , the lissencephaly gene product , with a mammalian homologue of a fungal nuclear distribution protein , rNUDE .
23795761	0	LITAF	0,5	BCL6	9,13	LITAF	BCL6	9516	604	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	LITAF , a BCL6 target gene , regulates autophagy in mature B-cell_lymphomas .
21980379	0	LITAF	51,56	CCL2	20,24	LITAF	CCL2	56722(Tax:10090)	20296(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Novel regulation of CCL2 gene expression by murine LITAF and STAT6B .
19426809	0	LITAF	95,100	LPS-induced_TNF-alpha_factor	65,93	LITAF	LPS-induced TNF-alpha factor	9516	9516	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization and expression analysis of a putative LPS-induced_TNF-alpha_factor -LRB- LITAF -RRB- from pearl oyster Pinctada fucata .
16954198	0	LITAF	30,35	TNF-alpha	12,21	LITAF	TNF-alpha	56722(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	LPS-induced TNF-alpha factor -LRB- LITAF -RRB- - deficient mice express reduced LPS-induced cytokine : Evidence for LITAF-dependent LPS signaling pathways .
18554501	0	LITAF	95,100	TNF-alpha	77,86	LITAF	TNF-alpha	9516	7124	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Identification and characterization of a putative lipopolysaccharide-induced TNF-alpha factor -LRB- LITAF -RRB- homolog from Singapore_grouper_iridovirus .
15487973	0	LK6	30,33	ERK	50,53	LK6	ERK	44672(Tax:7227)	3354888(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo .
22575644	0	LKB1	22,26	14-3-3	0,6	LKB1	14-3-3	6794	10971	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function .
15780593	0	LKB1	18,22	AMPK	25,29	LKB1	AMPK	6794	5563	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	New roles for the LKB1 -- > AMPK pathway .
19937189	0	LKB1	5,9	AMPK	60,64	LKB1	AMPK	314621(Tax:10116)	78975(Tax:10116)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|kinase kinase|appos|END_ENTITY	Does LKB1 mediate activation of hepatic AMP-protein kinase -LRB- AMPK -RRB- and sirtuin1 -LRB- SIRT1 -RRB- after Roux-en-Y_gastric_bypass in obese rats ?
20029389	0	LKB1	28,32	AMPK	83,87	LKB1	AMPK	6794	5563	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|regulation regulation|nmod|activation activation|compound|END_ENTITY	The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression .
21145922	0	LKB1	115,119	AMPK	28,32	LKB1	AMPK	6794	5563	Gene	Gene	dependent|nmod|START_ENTITY mediated|advcl|dependent mediated|nmod|END_ENTITY	eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1 .
21872575	0	LKB1	56,60	AMPK	0,4	LKB1	AMPK	6794	5563	Gene	Gene	pathway|compound|START_ENTITY senescence|nmod|pathway vascular|dobj|senescence induces|xcomp|vascular induces|nsubj|END_ENTITY	AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway .
24998845	0	LKB1	8,12	AMPK	30,34	LKB1	AMPK	6794	5563	Gene	Gene	isoform|compound|START_ENTITY enhances|nsubj|isoform enhances|dobj|activity activity|compound|END_ENTITY	A novel LKB1 isoform enhances AMPK metabolic activity and displays oncogenic properties .
25874865	0	LKB1	41,45	AMPK	19,23	LKB1	AMPK	6794	5562	Gene	Gene	Independently|nmod|START_ENTITY END_ENTITY|dobj|Independently	MLK3 Phophorylates AMPK Independently of LKB1 .
25874865	0	LKB1	41,45	AMPK	19,23	LKB1	AMPK	6794	5562	Gene	Gene	Independently|nmod|START_ENTITY END_ENTITY|dobj|Independently	MLK3 Phophorylates AMPK Independently of LKB1 .
11445556	0	LKB1	0,4	Brg1	21,25	LKB1	Brg1	6794	6597	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	LKB1 associates with Brg1 and is necessary for Brg1-induced growth_arrest .
26498531	0	LKB1	44,48	DEC1	0,4	LKB1	DEC1	20869(Tax:10090)	20893(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	DEC1 negatively regulates AMPK activity via LKB1 .
12489981	0	LKB1	46,50	Heat-shock_protein_90	0,21	LKB1	Heat-shock protein 90	6794	3320	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Heat-shock_protein_90 and Cdc37 interact with LKB1 and regulate its stability .
24054548	0	LKB1	0,4	KRAS	17,21	LKB1	KRAS	6794	3845	Gene	Gene	mutant|compound|START_ENTITY mutant|nmod|adenocarcinoma_of_the_lung adenocarcinoma_of_the_lung|compound|END_ENTITY	LKB1 mutant in a KRAS activated adenocarcinoma_of_the_lung associated with Peutz-Jeghers_syndrome : a case report .
20452353	0	LKB1	0,4	Kras	40,44	LKB1	Kras	6794	3845	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	LKB1 haploinsufficiency cooperates with Kras to promote pancreatic_cancer through suppression of p21-dependent growth_arrest .
16580634	0	LKB1	21,25	LMO4	71,75	LKB1	LMO4	6794	8543	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4 , GATA-6 , and Ldb1 .
22226967	0	LKB1	28,32	Liver_kinase_B1	0,15	LKB1	Liver kinase B1	6794	6794	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Liver_kinase_B1 expression -LRB- LKB1 -RRB- is repressed by estrogen_receptor_alpha -LRB- ERa -RRB- in MCF-7 human breast_cancer cells .
25155037	0	LKB1	91,95	Mir-155	0,7	LKB1	Mir-155	6794	406947	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	Mir-155 promotes cervical_cancer cell proliferation through suppression of its target gene LKB1 .
22983157	0	LKB1	44,48	Nur77	28,33	LKB1	Nur77	20869(Tax:10090)	15370(Tax:10090)	Gene	Gene	localization|nummod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK .
25850957	0	LKB1	14,18	PTEN	74,78	LKB1	PTEN	6794	5728	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of LKB1 on the PI3K/Akt Pathway Activation in Association with PTEN and PIK3CA in HNC .
23393134	0	LKB1	28,32	SIK2	66,70	LKB1	SIK2	6794	23235	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases .
10353780	0	LKB1	26,30	STK11	32,37	LKB1	STK11	6794	6794	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Germline mutations of the LKB1 -LRB- STK11 -RRB- gene in Peutz-Jeghers patients .
12805220	0	LKB1	43,47	STRAD	79,84	LKB1	STRAD	6794	92335	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD .
20974850	0	LKB1	52,56	TGFb	23,27	LKB1	TGFb	6794	7040	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of TGFb signaling by the kinase LKB1 and the scaffolding protein LIP1 .
26976973	0	LKB1	46,50	Tumor-suppressor	24,40	LKB1	Tumor-suppressor	6794	7248	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric_Cancer .
26701726	0	LKB1	19,23	bone_morphogenetic_protein	45,71	LKB1	bone morphogenetic protein	6794	649	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptor receptor|compound|END_ENTITY	The protein kinase LKB1 negatively regulates bone_morphogenetic_protein receptor signaling .
23637231	0	LKB1	0,4	focal_adhesion_kinase	15,36	LKB1	focal adhesion kinase	20869(Tax:10090)	14083(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	LKB1 represses focal_adhesion_kinase -LRB- FAK -RRB- signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence .
12045203	0	LKB1	21,25	p21	57,60	LKB1	p21	6794	1026	Gene	Gene	suppressor|compound|START_ENTITY Growth_arrest|nmod|suppressor Growth_arrest|dep|induction induction|nmod|END_ENTITY	Growth_arrest by the LKB1 tumor suppressor : induction of p21 -LRB- WAF1/CIP1 -RRB- .
16580634	0	LKB1	21,25	p21	34,37	LKB1	p21	6794	644914	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4 , GATA-6 , and Ldb1 .
20400510	0	LKB1	0,4	p21-activated_kinase-1	16,38	LKB1	p21-activated kinase-1	6794	5058	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	LKB1 suppresses p21-activated_kinase-1 -LRB- PAK1 -RRB- by phosphorylation of Thr109 in the p21-binding domain .
17108107	0	LKB1	0,4	p53	46,49	LKB1	p53	6794	7157	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation .
20368693	0	LKB1	11,15	p53	64,67	LKB1	p53	6794	7157	Gene	Gene	G|compound|START_ENTITY /|nsubj|G /|nmod|pathways pathways|compound|END_ENTITY	Endogenous LKB1 knockdown accelerates G -LRB- 1 -RRB- / S transition through p53 and p16 pathways .
21411391	0	LKB1	28,32	p53	107,110	LKB1	p53	6794	7157	Gene	Gene	gene|nummod|START_ENTITY mutation|nmod|gene diminished|nsubj|mutation diminished|dobj|activity activity|compound|END_ENTITY	A novel de novo mutation in LKB1 gene in a Chinese Peutz_Jeghers_syndrome patient significantly diminished p53 activity .
23995788	0	LKB1	0,4	p53	38,41	LKB1	p53	6794	7157	Gene	Gene	loss|nummod|START_ENTITY loss|parataxis|promotes promotes|nsubj|END_ENTITY	LKB1 loss by alteration of the NKX2-1 / p53 pathway promotes tumor malignancy and predicts poor survival and relapse in lung_adenocarcinomas .
25042259	0	LKB1	50,54	p53	92,95	LKB1	p53	6794	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Loss of LKB1 in high-grade endometrial_carcinoma : LKB1 is a novel transcriptional target of p53 .
25042259	0	LKB1	8,12	p53	92,95	LKB1	p53	6794	7157	Gene	Gene	Loss|nmod|START_ENTITY Loss|parataxis|target target|nmod|END_ENTITY	Loss of LKB1 in high-grade endometrial_carcinoma : LKB1 is a novel transcriptional target of p53 .
19812202	0	LL-37	27,32	APCs	71,75	LL-37	APCs	820	325	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs .
9837875	0	LL-37	80,85	Apolipoprotein_A-I	0,18	LL-37	Apolipoprotein A-I	820	335	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Apolipoprotein_A-I binds and inhibits the human antibacterial/cytotoxic peptide LL-37 .
19812202	0	LL-37	27,32	IFN-gamma	58,67	LL-37	IFN-gamma	820	3458	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs .
22486751	0	LL-37	16,21	IL-31	87,92	LL-37	IL-31	820	386653	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Decreased serum LL-37 and vitamin_D3 levels in atopic_dermatitis : relationship between IL-31 and oncostatin_M .
20375583	0	LL-37	21,26	IL-6	35,39	LL-37	IL-6	820	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Host defence peptide LL-37 induces IL-6 expression in human bronchial epithelial cells by activation of the NF-kappaB signaling pathway .
20570250	0	LL-37	36,41	IL-6	102,106	LL-37	IL-6	820	3569	Gene	Gene	Effect|nmod|START_ENTITY _|nsubj|Effect _|dobj|expression expression|nmod|END_ENTITY	Effect of the antimicrobial peptide LL-37 on Toll-like_receptors_2 - , _ 3 - _ and_4-triggered expression of IL-6 , IL-8 and CXCL10 in human gingival fibroblasts .
19307752	0	LL-37	0,5	IL-8	39,43	LL-37	IL-8	820	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	LL-37 inhibits serum_amyloid_A-induced IL-8 production in human neutrophils .
22069323	0	LL-37	96,101	Mas-related_gene_X2	0,19	LL-37	Mas-related gene X2	820	117194	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Mas-related_gene_X2 -LRB- MrgX2 -RRB- is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells : resistance to receptor phosphorylation , desensitization , and internalization .
20054823	0	LL-37	25,30	bone_morphogenetic_protein	63,89	LL-37	bone morphogenetic protein	820	649	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The host defense peptide LL-37 activates the tumor-suppressing bone_morphogenetic_protein signaling via inhibition of proteasome in gastric_cancer cells .
12860015	0	LL-37	14,19	hCAP-18	20,27	LL-37	hCAP-18	820	820	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|gene gene|amod|END_ENTITY	Expression of LL-37 / hCAP-18 gene in human leukemia cells .
15364108	0	LL-37	73,78	hCAP-18	65,72	LL-37	hCAP-18	820	820	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Bacterial products increase expression of the human cathelicidin hCAP-18 / LL-37 in cultured human sinus epithelial cells .
20646232	0	LL-37	30,35	hCAP-18	22,29	LL-37	hCAP-18	820	820	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Antimicrobial peptide hCAP-18 / LL-37 protein and mRNA expressions in different_periodontal_diseases .
26433491	0	LL-37	82,87	hCAP-18	74,81	LL-37	hCAP-18	820	820	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Vitamin_D3 modulates the innate immune response through regulation of the hCAP-18 / LL-37 gene expression and cytokine production .
24697598	0	LL-37	61,66	p33	25,28	LL-37	p33	820	3621	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability .
25100161	0	LL37	0,4	VEGF	13,17	LL37	VEGF	820	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	LL37 induces VEGF expression in dental pulp cells through ERK signalling .
22943069	0	LL37	22,26	vascular_endothelial_growth_factor-A	36,72	LL37	vascular endothelial growth factor-A	820	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Antimicrobial peptide LL37 promotes vascular_endothelial_growth_factor-A expression in human periodontal ligament cells .
23525008	0	LL5b	22,26	Amotl2	0,6	LL5b	Amotl2	90102	51421	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Amotl2 interacts with LL5b , localizes to podosomes and regulates postsynaptic differentiation in muscle .
8565641	0	LLGL	46,50	Llglh	34,39	LLGL	Llglh	16897(Tax:10090)	16897(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human homologue of the murine Llglh gene -LRB- LLGL -RRB- maps within the Smith-Magenis_syndrome region in 17p11 .2 .
26829983	0	LLT1	0,4	B_Cell_Activation	61,78	LLT1	B Cell Activation	29121	29760	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	LLT1 and CD161 Expression in Human Germinal Centers Promotes B_Cell_Activation and CXCR4 Downregulation .
24352438	0	LLT1	103,107	CD161	90,95	LLT1	CD161	29121	3820	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Respiratory_syncytial_virus_infection , TLR3 ligands , and proinflammatory cytokines induce CD161 ligand LLT1 expression on the respiratory epithelium .
16044454	0	LMAN1	56,61	MCFD2	17,22	FVIII	MCFD2	2157	90411	Gene	Gene	gene|compound|START_ENTITY Mutations|nmod|gene Mutations|nmod|gene gene|compound|END_ENTITY	Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency_of_factor_V and VIII .
17471240	0	LMO1	67,71	GASDERMIN	0,9	LMO1	GASDERMIN	4004	284110	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	GASDERMIN , suppressed frequently in gastric_cancer , is a target of LMO1 in TGF-beta-dependent apoptotic signalling .
16103065	0	LMO1	91,95	OLIG2	0,5	LMO1	OLIG2	109594(Tax:10090)	50913(Tax:10090)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	OLIG2 -LRB- BHLHB1 -RRB- , a bHLH transcription factor , contributes to leukemogenesis in concert with LMO1 .
16314316	0	LMO2	26,30	Bex2	6,10	LMO2	Bex2	4005	84707	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human Bex2 interacts with LMO2 and regulates the transcriptional activity of a novel DNA-binding complex .
21844373	0	LMO2	79,83	GATA1	127,132	LMO2	GATA1	4005	2623	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1 .
21573214	0	LMO3	10,14	HEN2	33,37	LMO3	HEN2	55885	4808	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1 .
26328011	0	LMO3	16,20	miR-630	0,7	LMO3	miR-630	55885	693215	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-630 targets LMO3 to regulate cell growth and metastasis in lung_cancer .
19995558	0	LMO3	0,4	p53	20,23	LMO3	p53	55885	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LMO3 interacts with p53 and inhibits its transcriptional activity .
21976498	0	LMO4	35,39	Alk	0,3	LMO4	Alk	16911(Tax:10090)	11682(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Alk is a transcriptional target of LMO4 and ERa that promotes cocaine sensitization and reward .
17452977	0	LMO4	20,24	BMP7	53,57	LMO4	BMP7	8543	655	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism , and controls cell proliferation and apoptosis of mammary epithelial cells .
11751867	0	LMO4	23,27	CtIP	56,60	LMO4	CtIP	8543	5932	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity .
22723967	0	LMO4	92,96	DEAF1	16,21	LMO4	DEAF1	8543	10522	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|domains domains|nummod|END_ENTITY	Contribution of DEAF1 structural domains to the interaction with the breast_cancer oncogene LMO4 .
25310299	0	LMO4	145,149	DEAF1	94,99	LMO4	DEAF1	8543	10522	Gene	Gene	Reveals|nmod|START_ENTITY Reveals|nsubj|Structure Structure|nmod|Protein Protein|appos|END_ENTITY	The Structure of an LIM-Only Protein 4 -LRB- LMO4 -RRB- and Deformed_Epidermal_Autoregulatory_Factor-1 -LRB- DEAF1 -RRB- Complex Reveals a Common Mode of Binding to LMO4 .
25310299	0	LMO4	40,44	DEAF1	94,99	LMO4	DEAF1	8543	10522	Gene	Gene	Protein|appos|START_ENTITY Protein|appos|END_ENTITY	The Structure of an LIM-Only Protein 4 -LRB- LMO4 -RRB- and Deformed_Epidermal_Autoregulatory_Factor-1 -LRB- DEAF1 -RRB- Complex Reveals a Common Mode of Binding to LMO4 .
12878195	0	LMO4	21,25	HEN1	68,72	LMO4	HEN1	8543	4807	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	The LIM-only protein LMO4 modulates the transcriptional activity of HEN1 .
16580634	0	LMO4	71,75	LKB1	21,25	LMO4	LKB1	8543	6794	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4 , GATA-6 , and Ldb1 .
25310299	0	LMO4	145,149	LMO4	40,44	LMO4	LMO4	8543	8543	Gene	Gene	Reveals|nmod|START_ENTITY Reveals|nsubj|Structure Structure|nmod|Protein Protein|appos|END_ENTITY	The Structure of an LIM-Only Protein 4 -LRB- LMO4 -RRB- and Deformed_Epidermal_Autoregulatory_Factor-1 -LRB- DEAF1 -RRB- Complex Reveals a Common Mode of Binding to LMO4 .
25310299	0	LMO4	40,44	LMO4	145,149	LMO4	LMO4	8543	8543	Gene	Gene	Protein|appos|START_ENTITY Structure|nmod|Protein Reveals|nsubj|Structure Reveals|nmod|END_ENTITY	The Structure of an LIM-Only Protein 4 -LRB- LMO4 -RRB- and Deformed_Epidermal_Autoregulatory_Factor-1 -LRB- DEAF1 -RRB- Complex Reveals a Common Mode of Binding to LMO4 .
15737692	0	LMO7	41,45	Transforming_growth_factor-beta1	0,32	LMO7	Transforming growth factor-beta1	361084(Tax:10116)	59086(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells .
20876453	0	LMP-1	127,132	EBNA-2	147,153	LMP-1	EBNA-2	17494204	17494192	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr_virus-encoded protein LMP-1 in absence of EBNA-2 : implications for the type II EBV latent gene expression in Hodgkin_lymphoma .
19250735	0	LMP-1	4,9	Par-4	72,77	LMP-1	Par-4	9260	5074	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal_carcinoma cells .
20876453	0	LMP-1	127,132	STAT6	0,5	LMP-1	STAT6	17494204	6778	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr_virus-encoded protein LMP-1 in absence of EBNA-2 : implications for the type II EBV latent gene expression in Hodgkin_lymphoma .
9242637	0	LMP-1	87,92	TRAF3	65,70	LMP-1	TRAF3	9260	7187	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Localization of the major NF-kappaB-activating site and the sole TRAF3 binding site of LMP-1 defines two distinct signaling motifs .
1321789	0	LMP-1	51,56	latent_membrane_protein	26,49	LMP-1	latent membrane protein	9260	9260	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of the EBV latent_membrane_protein -LRB- LMP-1 -RRB- is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin 's _ disease .
12673717	0	LMP-1	82,87	latent_membrane_protein_1	55,80	LMP-1	latent membrane protein 1	9260	9260	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Screening nasopharyngeal_carcinoma by detection of the latent_membrane_protein_1 -LRB- LMP-1 -RRB- gene with nasopharyngeal swabs .
10810379	0	LMP-7	84,89	MHC_class_I_antigen	22,41	LMP-7	MHC class I antigen	5696	100507703	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of MHC_class_I_antigen in human cancer cell lines with defective LMP-7 .
17546492	0	LMP1	75,79	AP-2	20,24	LMP1	AP-2	9260	7020	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Role of a consensus AP-2 regulatory sequence within the Epstein-Barr_virus LMP1 promoter in EBNA2 mediated transactivation .
27049918	0	LMP1	47,51	ATOH8	18,23	LMP1	ATOH8	9260	84913	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal_carcinoma .
17963943	0	LMP1	31,35	Bcl-3	111,116	LMP1	Bcl-3	9260	602	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The latent membrane protein 1 -LRB- LMP1 -RRB- encoded by Epstein-Barr_virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB .
17148591	0	LMP1	52,56	Bmi-1	0,5	LMP1	Bmi-1	9260	648	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Bmi-1 is induced by the Epstein-Barr_virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin_lymphoma cells .
9583684	0	LMP1	20,24	C15	16,19	LMP1	C15	9260	51316	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
7537255	0	LMP1	79,83	CD44	13,17	LMP1	CD44	17494204	960	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Induction of CD44 expression by the Epstein-Barr_virus latent membrane protein LMP1 is associated with lymphoma_dissemination .
21527913	0	LMP1	0,4	CD63	22,26	LMP1	CD63	9260	967	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-kB activation .
22589722	0	LMP1	27,31	Cdc42	64,69	LMP1	Cdc42	9260	998	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Epstein-Barr_virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal_carcinoma cells .
11783104	0	LMP1	51,55	EGFR	13,17	LMP1	EGFR	17494204	1956	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Increase of EGFR expression by Epstein-Barr_virus LMP1 in nasopharyngeal_carcinoma cells -RSB- .
15177893	0	LMP1	104,108	EGFR	147,151	LMP1	EGFR	9260	1956	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Nuclear factor kappa B -LRB- NFkappaB -RRB- dependent modulation of Epstein-Barr_virus latent membrane protein 1 -LRB- LMP1 -RRB- in epidermal growth factor receptor -LRB- EGFR -RRB- promoter activity .
21307189	0	LMP1	19,23	EGFR	34,38	LMP1	EGFR	9260	1956	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Epstein-Barr_virus LMP1 activates EGFR , STAT3 , and ERK through effects on PKCdelta .
24499623	0	LMP1	27,31	EGFR	81,85	LMP1	EGFR	9260	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Epstein-Barr_Virus encoded LMP1 regulates cyclin_D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells .
9583684	0	LMP1	20,24	EGFR	96,100	LMP1	EGFR	9260	1956	Gene	Gene	protein|compound|START_ENTITY confers|nsubj|protein confers|dobj|activation activation|nmod|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
26096068	0	LMP1	77,81	FGFR1	18,23	LMP1	FGFR1	9260	2260	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Activation of the FGFR1 signalling pathway by the Epstein-Barr_virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells .
25520502	0	LMP1	0,4	IGF1	58,62	LMP1	IGF1	9260	3479	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
25520502	0	LMP1	0,4	IGF1	88,92	LMP1	IGF1	9260	3479	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Receptor Receptor|compound|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
17013900	0	LMP1	24,28	IL-2-receptor_alpha	39,58	LMP1	IL-2-receptor alpha	9260	3559	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Concomitant increase of LMP1 and CD25 -LRB- IL-2-receptor_alpha -RRB- expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3 .
16778376	0	LMP1	88,92	IRF7	50,54	LMP1	IRF7	9260	3665	Gene	Gene	protein|appos|START_ENTITY membrane|dobj|protein membrane|nsubj|Colocalization Colocalization|nmod|interferon_regulatory_factor_7 interferon_regulatory_factor_7|appos|END_ENTITY	Colocalization of interferon_regulatory_factor_7 -LRB- IRF7 -RRB- with latent membrane protein 1 -LRB- LMP1 -RRB- of Epstein-Barr_virus .
20392859	0	LMP1	53,57	IRF7	72,76	LMP1	IRF7	9260	3665	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7 .
25520502	0	LMP1	0,4	Insulin-Like_Growth_Factor_1	28,56	LMP1	Insulin-Like Growth Factor 1	9260	3479	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	LMP1 Promotes Expression of Insulin-Like_Growth_Factor_1 -LRB- IGF1 -RRB- To Selectively Activate IGF1 Receptor and Drive Cell Proliferation .
11780335	0	LMP1	0,4	NF-kappa_B	15,25	LMP1	NF-kappa B	9260	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	LMP1 activates NF-kappa_B via degradation of I_kappa_B_alpha in nasopharyngeal_carcinoma cells .
7520093	0	LMP1	72,76	NF-kappa_B	133,143	LMP1	NF-kappa B	17494204	4790	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|dep|response response|acl:relcl|delayed delayed|nmod|activation activation|amod|END_ENTITY	Upregulation of bcl-2 by the Epstein-Barr_virus latent membrane protein LMP1 : a B-cell-specific response that is delayed relative to NF-kappa_B activation and to induction of cell surface markers .
7769726	0	LMP1	14,18	NF-kappa_B	85,95	LMP1	NF-kappa B	9260	4790	Gene	Gene	Expression|nmod|START_ENTITY leads|nsubj|Expression leads|nmod|activation activation|nmod|subset subset|nmod|proteins proteins|compound|END_ENTITY	Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa_B / Rel family proteins .
7845680	0	LMP1	50,54	NF-kappa_B	79,89	LMP1	NF-kappa B	9260	4790	Gene	Gene	protein-1|appos|START_ENTITY mediates|nsubj|protein-1 mediates|dobj|activation activation|nmod|phenotype phenotype|compound|END_ENTITY	The Epstein-Barr_virus latent membrane protein-1 -LRB- LMP1 -RRB- mediates activation of NF-kappa_B and cell surface phenotype via two effector regions in its carboxy-terminal cytoplasmic domain .
9583684	0	LMP1	20,24	NF-kappa_B	64,74	LMP1	NF-kappa B	9260	4790	Gene	Gene	protein|compound|START_ENTITY confers|nsubj|protein confers|dobj|activation activation|nmod|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
9813661	0	LMP1	78,82	NF-kappa_B	30,40	LMP1	NF-kappa B	9260	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|activity activity|amod|END_ENTITY	Transcriptional activation of NF-kappa_B activity by Epstein-Barr_virus _ -LRB- EBV -RRB- LMP1 as a selective therapeutic strategy for EBV-associated diseases .
17721998	0	LMP1	68,72	RANTES	14,20	LMP1	RANTES	9260	6352	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of RANTES and MCP-1 in epithelial cells is regulated via LMP1 and CD40 .
7769726	0	LMP1	14,18	Rel	96,99	LMP1	Rel	9260	5966	Gene	Gene	Expression|nmod|START_ENTITY leads|nsubj|Expression leads|nmod|activation activation|nmod|subset subset|nmod|proteins proteins|compound|END_ENTITY	Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa_B / Rel family proteins .
23975427	0	LMP1	94,98	TNFAIP2	47,54	LMP1	TNFAIP2	9260	7127	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	NF-kB-mediated transcriptional upregulation of TNFAIP2 by the Epstein-Barr_virus oncoprotein , LMP1 , promotes cell motility in nasopharyngeal_carcinoma .
11222727	0	LMP1	56,60	TRADD	0,5	LMP1	TRADD	9260	8717	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	TRADD domain of Epstein-Barr_virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts .
8950992	0	LMP1	93,97	TRAF3	114,119	LMP1	TRAF3	9260	7187	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr_Virus-encoded LMP1 : involvement of TRAF3 as a common mediator .
24499623	0	LMP1	27,31	cyclin_D1	42,51	LMP1	cyclin D1	9260	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Epstein-Barr_Virus encoded LMP1 regulates cyclin_D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells .
24814906	0	LMP1	0,4	eIF4E	37,42	LMP1	eIF4E	9260	1977	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|nmod|END_ENTITY	LMP1 stimulates the transcription of eIF4E to promote the proliferation , migration and invasion of human nasopharyngeal_carcinoma .
26397141	0	LMP1	0,4	eIF4E	56,61	LMP1	eIF4E	9260	1977	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	LMP1 promotes nasal NK/T-cell _ lymphoma cell function by eIF4E via NF-kB pathway .
8985387	0	LMP1	19,23	epidermal_growth_factor_receptor	41,73	LMP1	epidermal growth factor receptor	9260	1956	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Epstein-Barr_virus LMP1 induction of the epidermal_growth_factor_receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation .
9570524	0	LMP1	120,124	epidermal_growth_factor_receptor	155,187	LMP1	epidermal growth factor receptor	9260	1956	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|expression expression|compound|END_ENTITY	A fusion of the EBV latent membrane protein-1 -LRB- LMP1 -RRB- transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal_growth_factor_receptor expression , nuclear factor-kappa B , and stress-activated protein kinase .
9570524	0	LMP1	47,51	epidermal_growth_factor_receptor	155,187	LMP1	epidermal growth factor receptor	9260	1956	Gene	Gene	fusion|appos|START_ENTITY transmembrane|nsubj|fusion transmembrane|ccomp|similar similar|xcomp|LMP1 LMP1|nmod|activation activation|nmod|expression expression|compound|END_ENTITY	A fusion of the EBV latent membrane protein-1 -LRB- LMP1 -RRB- transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal_growth_factor_receptor expression , nuclear factor-kappa B , and stress-activated protein kinase .
16227255	0	LMP1	54,58	galectin_9	74,84	LMP1	galectin 9	9260	3965	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	In nasopharyngeal_carcinoma cells , Epstein-Barr_virus LMP1 interacts with galectin_9 in membrane raft elements resistant to simvastatin .
18087217	0	LMP1	140,144	latent_membrane_protein_1	113,138	LMP1	latent membrane protein 1	9260	9260	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Expression of immune-related molecules in primary EBV-positive Chinese nasopharyngeal_carcinoma : associated with latent_membrane_protein_1 -LRB- LMP1 -RRB- expression .
18851787	0	LMP1	70,74	latent_membrane_protein_1	43,68	LMP1	latent membrane protein 1	9260	9260	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	-LSB- Correlation of Epstein-Barr_virus-encoded latent_membrane_protein_1 -LRB- LMP1 -RRB- to fascin and phosphorylated Stat3 in nasopharyngeal_carcinoma -RSB- .
26698246	0	LMP1	27,31	miR-155	42,49	LMP1	miR-155	9260	406947	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Epstein-Barr_virus-encoded LMP1 increases miR-155 expression , which promotes radioresistance of nasopharyngeal_carcinoma via suppressing UBQLN1 .
22185663	0	LMP1	43,47	p53	56,59	LMP1	p53	9260	7157	Gene	Gene	reduces|nsubj|START_ENTITY reduces|iobj|levels levels|compound|END_ENTITY	Epstein-Barr_virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway .
22266808	0	LMP1	31,35	p53	70,73	LMP1	p53	9260	7157	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Epstein-Barr_virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal_carcinoma .
22684299	0	LMP1	18,22	p53	124,127	LMP1	p53	9260	7157	Gene	Gene	disrupts|nsubj|START_ENTITY disrupts|advcl|modulating modulating|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53 .
7907993	0	LMP2	77,81	RING12	83,89	LMP2	RING12	5698	5698	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	PRE3 , highly homologous to the human major histocompatibility complex-linked LMP2 -LRB- RING12 -RRB- gene , codes for a yeast proteasome subunit necessary for the peptidylglutamyl-peptide hydrolyzing activity .
16944024	0	LMP2	101,105	low_molecular_mass_polypeptide_2	67,99	LMP2	low molecular mass polypeptide 2	16912(Tax:10090)	16912(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Dextran sulfate sodium-induced colitis is associated with enhanced low_molecular_mass_polypeptide_2 -LRB- LMP2 -RRB- expression and is attenuated in LMP2 knockout mice .
15303969	0	LMP7	60,64	NS3	41,44	LMP7	NS3	5696	3845	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Hepatitis_C virus non-structural protein NS3 interacts with LMP7 , a component of the immunoproteasome , and affects its proteasome activity .
16646031	0	LMP7	64,68	proteasome_subunit_beta5i	37,62	LMP7	proteasome subunit beta5i	5696	5696	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Tissue-specific up-regulation of the proteasome_subunit_beta5i -LRB- LMP7 -RRB- in Sj gren 's _ syndrome .
12149261	1	LMW-PTP	147,154	PDGF-r	164,170	LMW-PTP	PDGF-r	52	5159	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|activity activity|amod|END_ENTITY	LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation .
24018208	0	LMX1A	46,51	Sp1	12,15	LMX1A	Sp1	4009	6667	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	The role of Sp1 and EZH2 in the regulation of LMX1A in cervical cancer cells .
8390628	0	LNGFR	115,120	low-affinity_nerve_growth_factor_receptor	72,113	LNGFR	low-affinity nerve growth factor receptor	24596(Tax:10116)	24596(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Nerve growth factor -LRB- NGF -RRB- , brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and low-affinity_nerve_growth_factor_receptor -LRB- LNGFR -RRB- mRNA levels in cultured rat Schwann cells ; differential time - and dose-dependent regulation by cAMP .
23590807	0	LNK	7,10	SH2B3	0,5	LNK	SH2B3	10019	10019	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	SH2B3 -LRB- LNK -RRB- mutations from myeloproliferative_neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F .
19701800	0	LNX	0,3	RhoC	46,50	LNX	RhoC	84708	389	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LNX -LRB- Ligand of Numb-protein X -RRB- interacts with RhoC , both of which regulate AP-1-mediated transcriptional activation .
25279559	0	LNX2	24,28	Caspr4	0,6	LNX2	Caspr4	140887(Tax:10090)	170571(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|compound|END_ENTITY	Caspr4 Interaction with LNX2 Modulates the Proliferation and Neuronal Differentiation of Mouse Neural Progenitor Cells .
7912753	0	LOH	37,40	p53	49,52	p53	p53	7157	7157	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	-LSB- Analysis of loss of heterozygosity -LRB- LOH -RRB- at the p53 and Rb suppressor genes in urinary_bladder_carcinoma -RSB- .
23196397	0	LOV1	5,9	phototropin2	30,42	LOV1	phototropin2	837635(Tax:3702)	835926(Tax:3702)	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Both LOV1 and LOV2 domains of phototropin2 function as the photosensory domain for hypocotyl phototropic responses in Arabidopsis_thaliana -LRB- Brassicaceae -RRB- .
26567111	0	LOX	50,53	Endo180	17,24	LOX	Endo180	4015	9902	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic_prostate_cancer cell migration on human ECM surfaces .
16511063	0	LOX	78,81	L-lactate_oxidase	59,76	LOX	L-lactate oxidase	4015	4015	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Crystallization and preliminary X-ray diffraction study of L-lactate_oxidase -LRB- LOX -RRB- , R181M mutant , from Aerococcus viridans .
18566459	0	LOX	61,64	Lysyl_oxidase	0,13	LOX	Lysyl oxidase	4015	4015	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Lysyl_oxidase activity in the ocular tissues and the role of LOX in proliferative_diabetic_retinopathy and rhegmatogenous_retinal_detachment .
23190333	0	LOX	42,45	Lysyl_oxidase	27,40	LOX	Lysyl oxidase	16948(Tax:10090)	16948(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression and role of Lysyl_oxidase -LRB- LOX -RRB- in dentinogenesis .
24502826	0	LOX	30,33	Lysyl_oxidase	15,28	LOX	Lysyl oxidase	4015	4015	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of Lysyl_oxidase -LRB- LOX -RRB- polymorphisms with the risk of Keratoconus in an Iranian population .
26398628	0	LOX	149,152	lipoxygenase	135,147	LOX	lipoxygenase	100037829(Tax:4577)	100037829(Tax:4577)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Resistance to Fusarium_verticillioides and fumonisin accumulation in maize inbred lines involves an earlier and enhanced expression of lipoxygenase -LRB- LOX -RRB- genes .
11005237	0	LOX	39,42	lysyl_oxidase	24,37	LOX	lysyl oxidase	4015	4015	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Selective expression of lysyl_oxidase -LRB- LOX -RRB- in the stromal reactions of broncho-pulmonary_carcinomas .
12685868	0	LOX	50,53	lysyl_oxidase	35,48	LOX	lysyl oxidase	16948(Tax:10090)	16948(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis of recombinant lysyl_oxidase -LRB- LOX -RRB- in myofibroblastlike cells .
15488859	0	LOX	73,76	lysyl_oxidase	36,49	LOX	lysyl oxidase	4015	4015	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	High levels of homocysteine inhibit lysyl_oxidase -LRB- LOX -RRB- and downregulate LOX expression in vascular endothelial cells .
21546528	0	LOX	98,101	lysyl_oxidase	83,96	LOX	lysyl oxidase	4015	4015	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Transforming_growth_factor-beta induces extracellular matrix protein cross-linking lysyl_oxidase -LRB- LOX -RRB- genes in human trabecular meshwork cells .
22883193	0	LOX	29,32	lysyl_oxidase	14,27	LOX	lysyl oxidase	4015	4015	Gene	Gene	Mechanism|appos|START_ENTITY Mechanism|nmod|END_ENTITY	-LSB- Mechanism of lysyl_oxidase -LRB- LOX -RRB- in breast_cancer invasion and metastasis -RSB- .
23748100	0	LOX	85,88	lysyl_oxidase	70,83	LOX	lysyl oxidase	4015	4015	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Gremlin utilizes canonical and non-canonical TGFb signaling to induce lysyl_oxidase -LRB- LOX -RRB- genes in human trabecular meshwork cells .
23970168	0	LOX	109,112	lysyl_oxidase	14,27	LOX	lysyl oxidase	4015	4015	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of lysyl_oxidase in human osteosarcoma and its clinical significance : a tumor suppressive role of LOX in human osteosarcoma cells .
24065528	0	LOX	38,41	lysyl_oxidase	23,36	LOX	lysyl oxidase	4015	4015	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of association of lysyl_oxidase -LRB- LOX -RRB- gene polymorphisms with intracranial aneurysm in a south Indian population .
25488748	0	LOX	16,19	miR30a	0,6	LOX	miR30a	4015	407029	Gene	Gene	Expression|compound|START_ENTITY Inhibits|dobj|Expression Inhibits|nsubj|END_ENTITY	miR30a Inhibits LOX Expression and Anaplastic Thyroid Cancer Progression .
10468518	0	LOX-1	23,28	Angiotensin_II	0,14	LOX-1	Angiotensin II	4973	183	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces LOX-1 , the human endothelial receptor for oxidized low-density lipoprotein .
17893372	0	LOX-1	74,79	Angiotensin_II	0,14	LOX-1	Angiotensin II	108078(Tax:10090)	11606(Tax:10090)	Gene	Gene	dependent|amod|START_ENTITY pathway|amod|dependent cells|nmod|pathway induces|nmod|cells induces|nsubj|END_ENTITY	Angiotensin_II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
15472120	0	LOX-1	28,33	C-reactive_protein	0,18	LOX-1	C-reactive protein	4973	1401	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	C-reactive_protein enhances LOX-1 expression in human aortic endothelial cells : relevance of LOX-1 to C-reactive_protein-induced endothelial_dysfunction .
15472120	0	LOX-1	93,98	C-reactive_protein	0,18	LOX-1	C-reactive protein	4973	1401	Gene	Gene	relevance|nmod|START_ENTITY expression|dep|relevance enhances|dobj|expression enhances|nsubj|END_ENTITY	C-reactive_protein enhances LOX-1 expression in human aortic endothelial cells : relevance of LOX-1 to C-reactive_protein-induced endothelial_dysfunction .
19074514	0	LOX-1	22,27	C-reactive_protein	37,55	LOX-1	C-reactive protein	140914(Tax:10116)	25419(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Oxidized LDL_receptor LOX-1 binds to C-reactive_protein and mediates its vascular effects .
23950953	0	LOX-1	122,127	C-reactive_protein	50,68	LOX-1	C-reactive protein	4973	1401	Gene	Gene	receptor|compound|START_ENTITY increases|nmod|receptor increases|dobj|expression expression|amod|END_ENTITY	Electronegative low-density lipoprotein increases C-reactive_protein expression in vascular endothelial cells through the LOX-1 receptor .
18326914	0	LOX-1	20,25	IL-10	11,16	LOX-1	IL-10	4973	3586	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of IL-10 on LOX-1 expression of peripheral blood monocytes in patients with acute_coronary_syndrome -RSB- .
23811604	0	LOX-1	19,24	IL-10	10,15	LOX-1	IL-10	4973	3586	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effect of IL-10 on LOX-1 expression , signalling and functional activity : an atheroprotective response .
12829655	0	LOX-1	29,34	LOX-1	56,61	LOX-1	LOX-1	4973	4973	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Glucose enhances endothelial LOX-1 expression : role for LOX-1 in glucose-induced human monocyte adhesion to endothelium .
12829655	0	LOX-1	56,61	LOX-1	29,34	LOX-1	LOX-1	4973	4973	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Glucose enhances endothelial LOX-1 expression : role for LOX-1 in glucose-induced human monocyte adhesion to endothelium .
15001526	0	LOX-1	34,39	LOX-1	61,66	LOX-1	LOX-1	4973	4973	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Glucose enhances human macrophage LOX-1 expression : role for LOX-1 in glucose-induced macrophage foam cell formation .
15001526	0	LOX-1	61,66	LOX-1	34,39	LOX-1	LOX-1	4973	4973	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Glucose enhances human macrophage LOX-1 expression : role for LOX-1 in glucose-induced macrophage foam cell formation .
18191942	0	LOX-1	34,39	LOXIN	19,24	LOX-1	LOXIN	4973	4973	Gene	Gene	function|compound|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization .
19218767	0	LOX-1	37,42	Lectin-like_oxidized_LDL_receptor-1	0,35	LOX-1	Lectin-like oxidized LDL receptor-1	4973	4973	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in the tubulointerstitial area likely plays an important role in human diabetic_nephropathy .
17888218	0	LOX-1	57,62	Lectin-like_oxidized_low_density_lipoprotein_receptor_1	0,55	LOX-1	Lectin-like oxidized low density lipoprotein receptor 1	4973	4973	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lectin-like_oxidized_low_density_lipoprotein_receptor_1 -LRB- LOX-1 -RRB- expression in human articular chondrocytes .
16173915	0	LOX-1	57,62	Oct-1	94,99	LOX-1	Oct-1	4973	5451	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- transcriptional regulation by Oct-1 in human endothelial cells : implications for atherosclerosis .
16266460	4	LOX-1	719,724	TLR4	713,717	LOX-1	TLR4	4973	7099	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	METHODS : HUVECs were incubated with purified LPS for 24 h. TLR4 , LOX-1 , ICAM-1 , E-selectin mRNA were measured by RT-PCR ; the protein expression of TLR4 , LOX-1 and activation of NF-kappaB were detected by Western blot ; the adhesive percentage between HUVECs and monocytes was determined by direct counting .
24615033	5	LOX-1	1082,1087	TLR4	1076,1080	LOX-1	TLR4	4973	7099	Gene	Gene	MCP-1|appos|START_ENTITY MCP-1|compound|END_ENTITY	After 48 h of processing HUVECs with pyrrolidine_dithiocarbamate -LRB- PDTC -RRB- , protein expressions of TLR4 , LOX-1 , MCP-1 , and VCAM - _ 1 were detected by Western blot .
17868983	0	LOX-1	17,22	TNF-alpha	37,46	LOX-1	TNF-alpha	4973	7124	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of LOX-1 expression by TNF-alpha promotes trans-endothelial migration of MDA-MB-231 breast_cancer cells .
19126408	0	LOX-1	0,5	angiotensin_II	83,97	LOX-1	angiotensin II	108078(Tax:10090)	11606(Tax:10090)	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|END_ENTITY	LOX-1 dependent overexpression of immunoglobulins in cardiomyocytes in response to angiotensin_II .
25005756	0	LOX-1	0,5	angiotensin_II	57,71	LOX-1	angiotensin II	108078(Tax:10090)	11606(Tax:10090)	Gene	Gene	deletion|compound|START_ENTITY limits|nsubj|deletion limits|nmod|mice mice|acl|given given|dobj|END_ENTITY	LOX-1 deletion limits cardiac angiogenesis in mice given angiotensin_II .
26498522	0	LOX-1	90,95	desmoglein_1	44,56	LOX-1	desmoglein 1	4973	1828	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Oxidized low-density lipoprotein attenuated desmoglein_1 and desmocollin_2 expression via LOX-1 / Ca -LRB- 2 + -RRB- / PKC-b signal in human umbilical vein endothelial cells .
19782984	0	LOX-1	58,63	lectin-like_oxidized_LDL_receptor	23,56	LOX-1	lectin-like oxidized LDL receptor	108078(Tax:10090)	108078(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Palmitic_acid enhances lectin-like_oxidized_LDL_receptor -LRB- LOX-1 -RRB- expression and promotes uptake of oxidized LDL in macrophage cells .
11573959	0	LOX-1	55,60	lectin-like_oxidized_LDL_receptor-1	18,53	LOX-1	lectin-like oxidized LDL receptor-1	140914(Tax:10116)	140914(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Diabetes enhances lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in the vascular endothelium : possible role of LOX-1 ligand and AGE .
15855339	0	LOX-1	61,66	lectin-like_oxidized_LDL_receptor-1	24,59	LOX-1	lectin-like oxidized LDL receptor-1	4973	4973	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Linoleic acid increases lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in human aortic endothelial cells .
17055514	0	LOX-1	144,149	lectin-like_oxidized_LDL_receptor-1	107,142	LOX-1	lectin-like oxidized LDL receptor-1	281368(Tax:9913)	281368(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB -LRB- NF-kappaB -RRB- activation and lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in vascular endothelial cells .
16790013	0	LOX-1	95,100	lectin-like_oxidized_low-density_lipoprotein_receptor	40,93	LOX-1	lectin-like oxidized low-density lipoprotein receptor	4973	4973	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Chlamydia_pneumoniae_infection enhances lectin-like_oxidized_low-density_lipoprotein_receptor -LRB- LOX-1 -RRB- expression on human endothelial cells .
9837956	0	LOX-1	112,117	lectin-like_oxidized_low-density_lipoprotein_receptor	57,110	LOX-1	lectin-like oxidized low-density lipoprotein receptor	140914(Tax:10116)	140914(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and regulation of expression of the lectin-like_oxidized_low-density_lipoprotein_receptor -LRB- LOX-1 -RRB- gene .
15010359	0	LOX-1	73,78	lectin-like_oxidized_low-density_lipoprotein_receptor-1	16,71	LOX-1	lectin-like oxidized low-density lipoprotein receptor-1	4973	4973	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- in endothelial cells by nitric_oxide deficiency .
15480893	0	LOX-1	65,70	lectin-like_oxidized_low-density_lipoprotein_receptor-1	8,63	LOX-1	lectin-like oxidized low-density lipoprotein receptor-1	281368(Tax:9913)	281368(Tax:9913)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- in the development of hypertensive organ damage .
18474940	0	LOX-1	88,93	lectin-like_oxidized_low-density_lipoprotein_receptor-1	31,86	LOX-1	lectin-like oxidized low-density lipoprotein receptor-1	108078(Tax:10090)	4973	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- in murine and human placentas .
18469066	0	LOX-1	80,85	lectin-like_oxidized_low-density_lipoprotein_receptor_1	23,78	LOX-1	lectin-like oxidized low-density lipoprotein receptor 1	4973	4973	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variation in the human lectin-like_oxidized_low-density_lipoprotein_receptor_1 -LRB- LOX-1 -RRB- gene is associated with plasma soluble LOX-1 levels .
12810610	0	LOX1	78,82	lectin-like_oxidized_low-density_lipoprotein_receptor_1	21,76	LOX1	lectin-like oxidized low-density lipoprotein receptor 1	4973	4973	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in lectin-like_oxidized_low-density_lipoprotein_receptor_1 -LRB- LOX1 -RRB- gene and the risk of coronary_artery_disease .
18191942	0	LOXIN	19,24	LOX-1	34,39	LOXIN	LOX-1	4973	4973	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|compound|END_ENTITY	The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization .
10022501	0	LOXL	45,49	lysyl_oxidase-like	20,38	LOXL	lysyl oxidase-like	16949(Tax:10090)	16949(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Coexpression of the lysyl_oxidase-like gene -LRB- LOXL -RRB- and the gene encoding type III procollagen in induced liver_fibrosis .
15609098	0	LOXL	95,99	lysyl_oxidase-like	75,93	LOXL	lysyl oxidase-like	16949(Tax:10090)	16949(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Comparative immunocytochemical localization of lysyl_oxidase -LRB- LOX -RRB- and the lysyl_oxidase-like -LRB- LOXL -RRB- proteins : changes in the expression of LOXL during development and growth of mouse tissues .
10773658	0	LOXL1	44,49	lysyl_oxidase-like	24,42	LOXL1	lysyl oxidase-like	4016	4016	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Physical linkage of the lysyl_oxidase-like -LRB- LOXL1 -RRB- gene to the PML gene on human chromosome 15q22 .
17354256	0	LOXL4	70,75	lysyl_oxidase_like-4	48,68	LOXL4	lysyl oxidase like-4	84171	84171	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Selective upregulation and amplification of the lysyl_oxidase_like-4 -LRB- LOXL4 -RRB- gene in head_and_neck_squamous_cell_carcinoma .
23572561	0	LOXL4	0,5	transforming_growth_factor_b1	20,49	LOXL4	transforming growth factor b1	84171	7040	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	LOXL4 is induced by transforming_growth_factor_b1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling .
21878565	0	LPA1	109,113	lysophosphatidic_acid_receptor_1	75,107	LPA1	lysophosphatidic acid receptor 1	1902	1902	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic_acid_receptor_1 -LRB- LPA1 -RRB- signaling .
24828490	0	LPA1	124,128	lysophosphatidic_acid_receptor_type_1	85,122	LPA1	lysophosphatidic acid receptor type 1	1902	1902	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Identification of heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- as a biomarker for lysophosphatidic_acid_receptor_type_1 -LRB- LPA1 -RRB- activation in human breast_and_prostate_cancers .
26048993	0	LPCAT1	0,6	StarD10	35,42	LPCAT1	StarD10	79888	10809	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	LPCAT1 Specifically Interacts with StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type_II_Cells .
20837115	0	LPCAT3	14,20	LXR	24,27	LPCAT3	LXR	418293(Tax:9031)	395221(Tax:9031)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of LPCAT3 by LXR .
6143618	0	LPH	68,71	MSH	63,66	LPH	MSH	3938	5443	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Differentiation of cells producing polypeptide hormones -LRB- ACTH , MSH , LPH , alpha - _ and_beta-endorphin , GH and PRL -RRB- in the fetal porcine anterior pituitary .
20157310	0	LPHN3	44,49	latrophilin_3	24,37	LPHN3	latrophilin 3	23284	23284	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common variant of the latrophilin_3 gene , LPHN3 , confers susceptibility to ADHD and predicts effectiveness of stimulant medication .
17890220	0	LPL	116,119	GIP	76,79	LPL	GIP	24539(Tax:10116)	25040(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY stimulation|nmod|activity stimulation|appos|END_ENTITY	Resistin is a key mediator of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- stimulation of lipoprotein_lipase -LRB- LPL -RRB- activity in adipocytes .
20693566	0	LPL	101,104	GIP	0,3	LPL	GIP	4023	2695	Gene	Gene	gene|compound|START_ENTITY trans-activation|nmod|gene increases|nmod|trans-activation increases|nsubj|END_ENTITY	GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene .
20693566	0	LPL	30,33	GIP	0,3	LPL	GIP	4023	2695	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene .
21334410	0	LPL	72,75	GIP	37,40	LPL	GIP	16956(Tax:10090)	14607(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY decreases|dobj|activity decreases|nsubj|administration administration|nmod|analog analog|compound|END_ENTITY	Sub-chronic administration of stable GIP analog in mice decreases serum LPL activity and body weight .
18986377	0	LPL	75,78	GSTM1	49,54	LPL	GSTM1	4023	2944	Gene	Gene	PSTI|appos|START_ENTITY PSTI|compound|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
18986377	0	LPL	75,78	GSTT1	56,61	LPL	GSTT1	4023	2952	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
12690214	0	LPL	20,23	Lipoprotein_lipase	0,18	LPL	Lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lipoprotein_lipase -LRB- LPL -RRB- gene variation and progression of carotid_artery_plaque .
24703657	0	LPL	28,31	Lipoprotein_lipase	8,26	LPL	Lipoprotein lipase	4023	4023	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	A novel Lipoprotein_lipase -LRB- LPL -RRB- agonist rescues the enzyme from inhibition by angiopoietin-like_4 -LRB- ANGPTL4 -RRB- .
22963823	0	LPL	22,25	MicroRNA-467b	0,13	LPL	MicroRNA-467b	16956(Tax:10090)	735257(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MicroRNA-467b targets LPL gene in RAW 264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion .
18986377	0	LPL	75,78	NAT2	69,73	LPL	NAT2	4023	10	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
18986377	0	LPL	75,78	NQO1	63,67	LPL	NQO1	4023	1728	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
18986377	0	LPL	75,78	PRSS1	80,85	LPL	PRSS1	4023	5644	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
25066055	0	LPL	62,65	Sel1L	46,51	LPL	Sel1L	16956(Tax:10090)	20338(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism .
10407500	0	LPL	50,53	lipoprotein_lipase	30,48	LPL	lipoprotein lipase	4023	4023	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Evidence of a major locus for lipoprotein_lipase -LRB- LPL -RRB- activity in addition to a pleiotropic locus for both LPL and fasting insulin : results from the HERITAGE Family Study .
11395037	0	LPL	49,52	lipoprotein_lipase	24,42	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common mutations in the lipoprotein_lipase gene -LRB- LPL -RRB- : effects on HDL-cholesterol levels in a Chinese Canadian population .
12687649	0	LPL	40,43	lipoprotein_lipase	20,38	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between lipoprotein_lipase -LRB- LPL -RRB- gene and blood lipids : a common variant for a common trait ?
1406652	0	LPL	50,53	lipoprotein_lipase	30,48	LPL	lipoprotein lipase	4023	4023	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Characterization of the human lipoprotein_lipase -LRB- LPL -RRB- promoter : evidence of two cis-regulatory regions , LP-alpha and LP-beta , of importance for the differentiation-linked induction of the LPL gene during adipogenesis .
1562620	0	LPL	74,77	lipoprotein_lipase	54,72	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A newly identified null allelic mutation in the human lipoprotein_lipase -LRB- LPL -RRB- gene of a compound heterozygote with familial_LPL_deficiency .
16029634	0	LPL	35,38	lipoprotein_lipase	15,33	LPL	lipoprotein lipase	4023	4023	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	-LSB- The effect of lipoprotein_lipase -LRB- LPL -RRB- polymorphism on plasma LPL concentration and triglyceride -RSB- .
17727701	0	LPL	61,64	lipoprotein_lipase	41,59	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The D9N , N291S and S447X variants in the lipoprotein_lipase -LRB- LPL -RRB- gene are not associated with Type_III_hyperlipidemia .
17890220	0	LPL	116,119	lipoprotein_lipase	96,114	LPL	lipoprotein lipase	24539(Tax:10116)	24539(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Resistin is a key mediator of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- stimulation of lipoprotein_lipase -LRB- LPL -RRB- activity in adipocytes .
18619685	0	LPL	48,51	lipoprotein_lipase	28,46	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Apolipoprotein_E -LRB- APOE -RRB- and lipoprotein_lipase -LRB- LPL -RRB- gene variants and carotid atherosclerotic_lesions in the oldest old : a population-based autopsy study .
18985010	0	LPL	35,38	lipoprotein_lipase	15,33	LPL	lipoprotein lipase	4023	4023	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of lipoprotein_lipase -LRB- LPL -RRB- single nucleotide polymorphisms with type_2_diabetes_mellitus .
21159338	0	LPL	41,44	lipoprotein_lipase	21,39	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rare variants in the lipoprotein_lipase -LRB- LPL -RRB- gene are common in hypertriglyceridemia but rare in Type_III_hyperlipidemia .
23271120	0	LPL	90,93	lipoprotein_lipase	70,88	LPL	lipoprotein lipase	280843(Tax:9913)	280843(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of novel single nucleotide polymorphisms -LRB- SNPs -RRB- of the lipoprotein_lipase -LRB- LPL -RRB- gene associated with fatty_acid composition in Korean cattle .
24314358	0	LPL	65,68	lipoprotein_lipase	45,63	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Resequencing the untranslated regions of the lipoprotein_lipase -LRB- LPL -RRB- gene reveals that variants in microRNA target sequences are associated with triglyceride levels .
7753827	0	LPL	54,57	lipoprotein_lipase	34,52	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A mutation in the promoter of the lipoprotein_lipase -LRB- LPL -RRB- gene in a patient with familial_combined_hyperlipidemia and low LPL activity .
8314591	0	LPL	75,78	lipoprotein_lipase	55,73	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human clusterin -LRB- CLI -RRB- maps to 8p21 in proximity to the lipoprotein_lipase -LRB- LPL -RRB- gene .
8449037	0	LPL	44,47	lipoprotein_lipase	24,42	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human lipoprotein_lipase -LRB- LPL -RRB- gene to chromosome band 8p22 .
8728326	0	LPL	64,67	lipoprotein_lipase	44,62	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Homozygosity for two point mutations in the lipoprotein_lipase -LRB- LPL -RRB- gene in a patient with familial_LPL_deficiency : LPL -LRB- Asp9 -- > Asn , Tyr262 -- > His -RRB- .
8732780	0	LPL	92,95	lipoprotein_lipase	37,55	LPL	lipoprotein lipase	16956(Tax:10090)	16956(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|production production|amod|END_ENTITY	Role of oxidant injury on macrophage lipoprotein_lipase -LRB- LPL -RRB- production and sensitivity to LPL .
9034134	0	LPL	43,46	lipoprotein_lipase	23,41	LPL	lipoprotein lipase	16956(Tax:10090)	16956(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Prolactin 's effects on lipoprotein_lipase -LRB- LPL -RRB- activity and on LPL mRNA levels in cultured mouse mammary gland explants .
9714430	0	LPL	51,54	lipoprotein_lipase	31,49	LPL	lipoprotein lipase	4023	4023	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ile225Thr loop mutation in the lipoprotein_lipase -LRB- LPL -RRB- gene is a de novo event .
15649318	0	LPP	68,71	Scrib	21,26	LPP	Scrib	4026	23513	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The tumor suppressor Scrib interacts with the zyxin-related protein LPP , which shuttles between cell adhesion sites and the nucleus .
12441356	0	LPP	98,101	lipoma-preferred_partner	72,96	LPP	lipoma-preferred partner	4026	4026	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred_partner -LRB- LPP -RRB- protein .
11163183	0	LPS	23,26	TNF-alpha	0,9	LPS	TNF-alpha	21898(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway .
11715476	0	LPS	47,50	TNF-alpha	54,63	LPS	TNF-alpha	3664	7124	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The role of activation of p38 MAPK induced by LPS in TNF-alpha gene expression -RSB- .
9766626	0	LPS	90,93	TNF-alpha	135,144	LPS	TNF-alpha	21898(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Ionizing radiation potentiates the induction of nitric_oxide_synthase by IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha .
7515085	0	LPS-binding_protein	58,77	LBP	79,82	LPS-binding protein	LBP	3929	3929	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Radioimmunoassay versus flow cytometric assay to quantify LPS-binding_protein -LRB- LBP -RRB- concentrations in human plasma .
10219599	0	LPS-binding_protein	29,48	decay-accelerating_factor	60,85	LPS-binding protein	decay-accelerating factor	3929	1604	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the 80-kDa LPS-binding_protein -LRB- LMP80 -RRB- as decay-accelerating_factor -LRB- DAF , CD55 -RRB- .
19426809	0	LPS-induced_TNF-alpha_factor	65,93	LITAF	95,100	LPS-induced TNF-alpha factor	LITAF	9516	9516	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization and expression analysis of a putative LPS-induced_TNF-alpha_factor -LRB- LITAF -RRB- from pearl oyster Pinctada fucata .
15090700	0	LQT2	63,67	HERG	69,73	LQT2	HERG	3757	3757	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Long-term follow-up of notched T waves in female patients with LQT2 -LRB- HERG -RRB- mutations .
22173492	0	LQT2	53,57	hERG	36,40	LQT2	hERG	3757	2078	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	Electrophysiological study of V535M hERG mutation of LQT2 .
14764453	0	LR11	0,4	LDL_receptor	9,21	LR11	LDL receptor	20660(Tax:10090)	16835(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	LR11 , an LDL_receptor gene family member , is a novel regulator of smooth muscle cell migration .
19853566	0	LRF	0,3	GATA1	41,46	LRF	GATA1	51341	2623	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis .
23868260	0	LRG1	0,4	TGF-b	53,58	LRG1	TGF-b	76905(Tax:10090)	21803(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|modulating modulating|dobj|signalling signalling|amod|END_ENTITY	LRG1 promotes angiogenesis by modulating endothelial TGF-b signalling .
26049667	0	LRG1	0,4	TGF-b	67,72	LRG1	TGF-b	116844	7040	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	LRG1 modulates invasion and migration_of_glioma cell lines through TGF-b signaling pathway .
25987835	0	LRH-1	55,60	Apolipoprotein_M	0,16	LRH-1	Apolipoprotein M	2494	55937	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Apolipoprotein_M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells .
25987835	0	LRH-1	55,60	Apolipoprotein_M	0,16	LRH-1	Apolipoprotein M	2494	55937	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Apolipoprotein_M regulates the orphan nuclear receptor LRH-1 gene expression through binding to its promoter region in HepG2 cells .
20937355	0	LRH-1	0,5	Dax1	25,29	LRH-1	Dax1	26424(Tax:10090)	11614(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	LRH-1 and Nanog regulate Dax1 transcription in mouse embryonic stem cells .
24737860	0	LRH-1	17,22	NR5A2	23,28	LRH-1	NR5A2	26424(Tax:10090)	26424(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	Nuclear receptor LRH-1 / NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution .
25896302	0	LRH-1	0,5	SF-1	17,21	LRH-1	SF-1	2494	7536	Gene	Gene	Deficiency|compound|START_ENTITY Deficiency|compound|END_ENTITY	LRH-1 May Rescue SF-1 Deficiency for Steroidogenesis : An in vitro and in vivo Study .
17977826	0	LRH-1	95,100	apolipoprotein_M	31,47	LRH-1	apolipoprotein M	2494	55937	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of anti-atherogenic apolipoprotein_M gene expression by the orphan nuclear receptor LRH-1 .
23504956	0	LRH-1	17,22	kisspeptin	61,71	LRH-1	kisspeptin	26424(Tax:10090)	280287(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus .
22961990	0	LRH-1	54,59	liver_receptor_homolog-1	28,52	LRH-1	liver receptor homolog-1	2494	2494	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of a new class of liver_receptor_homolog-1 -LRB- LRH-1 -RRB- antagonists : virtual screening , synthesis and biological evaluation .
22100809	0	LRH-1_and_SHP	51,64	PPARa	44,49	LRH-1 and SHP	PPARa	2494;8431	5465	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of miR-200c by nuclear receptors PPARa , LRH-1_and_SHP .
25048475	0	LRIG1	0,5	BCL-2	46,51	LRIG1	BCL-2	26018	596	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|modulating modulating|dobj|expression expression|compound|END_ENTITY	LRIG1 enhances chemosensitivity by modulating BCL-2 expression and receptor_tyrosine_kinase signaling in glioma cells .
25323917	0	LRIG1	12,17	BCL-2	58,63	LRIG1	BCL-2	26018	596	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Erratum to `` LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor_Tyrosine_Kinase Signaling in Glioma Cells '' by Guo Z , et al. -LRB- Yonsei Med J 2014 ; 55:1196 -205 . -RRB- .
25449296	0	LRIG1	0,5	BCL-2	54,59	LRIG1	BCL-2	26018	596	Gene	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	LRIG1 Improves Chemosensitivity Through Inhibition of BCL-2 and MnSOD in Glioblastoma .
25492572	0	LRIG1	12,17	BCL-2	58,63	LRIG1	BCL-2	26018	596	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	Erratum to `` LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor_Tyrosine_Kinase Signaling in Glioma Cells '' by Guo Z , et al. -LRB- Yonsei Med J 2014 ; 55:1196 -205 . -RRB- .
23850692	0	LRIG1	0,5	Bcl-2	130,135	LRIG1	Bcl-2	26018	596	Gene	Gene	dictates|nsubj|START_ENTITY dictates|nmod|cells cells|nmod|down-regulation down-regulation|nmod|END_ENTITY	LRIG1 dictates the chemo-sensitivity of temozolomide -LRB- TMZ -RRB- in U251 glioblastoma cells via down-regulation of EGFR/topoisomerase -2 / Bcl-2 .
25801120	0	LRIG1	0,5	EGFR	13,17	LRIG1	EGFR	26018	1956	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	LRIG1 , human EGFR inhibitor , reverses multidrug resistance through modulation of ABCB1 and ABCG2 .
20553099	0	LRIG1	21,26	LRIG2	0,5	LRIG1	LRIG2	26018	9860	Gene	Gene	contrast|nmod|START_ENTITY END_ENTITY|nmod|contrast	LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous_cell_carcinoma_of_the_uterine_cervix .
20553099	0	LRIG2	0,5	LRIG1	21,26	LRIG2	LRIG1	9860	26018	Gene	Gene	START_ENTITY|nmod|contrast contrast|nmod|END_ENTITY	LRIG2 in contrast to LRIG1 predicts poor survival in early-stage squamous_cell_carcinoma_of_the_uterine_cervix .
11245926	0	LRP	95,98	APP	56,59	LRP	APP	4035	351	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP .
14659844	0	LRP	38,41	LDL_receptor-related_protein	8,36	LRP	LDL receptor-related protein	4035	4035	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of LDL_receptor-related_protein -LRB- LRP -RRB- in coronary_atherosclerosis .
15698441	0	LRP	57,60	LDL_receptor-related_protein	27,55	LRP	LDL receptor-related protein	25167(Tax:10116)	25167(Tax:10116)	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of hepatic LDL_receptor-related_protein -LRB- LRP -RRB- in chronic_renal_failure .
15017692	0	LRP	41,44	MRP	36,39	LRP	MRP	9961	4363	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	-LSB- Expression and implication of Pgp , MRP , LRP , GST-pi , Topo II alpha in tongue_squamous_cell_carcinoma -RSB- .
18972317	0	LRP	83,86	MRP	47,50	LRP	MRP	9961	4363	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma : further exploring the role of P53 and WT1 gene .
7671223	0	LRP	4,7	MRP	169,172	LRP	MRP	4035	4363	Gene	Gene	gene|compound|START_ENTITY proximal|nsubj|gene proximal|xcomp|MRP MRP|nmod|chromosome chromosome|dep|evidence evidence|dep|plays plays|dobj|role role|nmod|amplification amplification|compound|END_ENTITY	The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16 : evidence that chromosome breakage plays a key role in MRP or LRP gene amplification .
7671223	0	LRP	4,7	MRP	93,96	LRP	MRP	4035	4363	Gene	Gene	gene|compound|START_ENTITY proximal|nsubj|gene proximal|xcomp|END_ENTITY	The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16 : evidence that chromosome breakage plays a key role in MRP or LRP gene amplification .
8798151	0	LRP	119,122	PAI-1	99,104	LRP	PAI-1	16971(Tax:10090)	18787(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Embryo implantation in mouse : fetomaternal coordination in the pattern of expression of uPA , uPAR , PAI-1 and alpha_2MR / LRP genes .
8790445	0	LRP	78,81	PTP_alpha	68,77	LRP	PTP alpha	16971(Tax:10090)	19262(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Regional localization of rat and mouse protein-tyrosine phosphatase PTP_alpha / LRP gene -LRB- Ptpra -RRB- by fluorescence in situ hybridization .
8790445	0	LRP	78,81	Ptpra	88,93	LRP	Ptpra	16971(Tax:10090)	19262(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regional localization of rat and mouse protein-tyrosine phosphatase PTP_alpha / LRP gene -LRB- Ptpra -RRB- by fluorescence in situ hybridization .
11435418	1	LRP	144,147	alpha_2-macroglobulin	59,80	LRP	alpha 2-macroglobulin	4035	2	Gene	Gene	lipoprotein_receptor-related_protein|appos|START_ENTITY complex|nmod|lipoprotein_receptor-related_protein complex|amod|END_ENTITY	alpha_2-macroglobulin complex with low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- .
11435418	2	LRP	188,191	alpha_2-macroglobulin	166,187	LRP	alpha 2-macroglobulin	4035	2	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Evidence for an alpha_2-macroglobulin / LRP receptor-mediated system participating in LCAT clearance .
7518435	0	LRP	81,84	lipoprotein_receptor-related_protein	43,79	LRP	lipoprotein receptor-related protein	4035	4035	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of the low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- in mammalian central neurons .
9350853	0	LRP	77,80	lipoprotein_receptor-related_protein	39,75	LRP	lipoprotein receptor-related protein	4035	4035	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No association between the low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- gene and late-onset Alzheimer 's _ disease in a community-based sample .
17346883	0	LRP	86,89	low-density_lipoprotein_receptor	36,68	LRP	low-density lipoprotein receptor	16971(Tax:10090)	16835(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Estradiol replacement increases the low-density_lipoprotein_receptor related protein -LRB- LRP -RRB- in the mouse brain .
12110277	0	LRP	45,48	lung_resistance-related_protein	12,43	LRP	lung resistance-related protein	9961	9961	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the lung_resistance-related_protein -LRB- LRP -RRB- in the drug sensitivity of cultured tumor cells .
15154630	0	LRP	72,75	lung_resistance-related_protein	39,70	LRP	lung resistance-related protein	9961	9961	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Expression and prognostic value of the lung_resistance-related_protein -LRB- LRP -RRB- in germ cell testicular_tumors .
17438350	0	LRP	75,78	lung_resistance-related_protein	42,73	LRP	lung resistance-related protein	9961	9961	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunolocalization and cell expression of lung_resistance-related_protein -LRB- LRP -RRB- in normal and tumoral human respiratory cells .
9311441	0	LRP	47,50	lung_resistance-related_protein	14,45	LRP	lung resistance-related protein	9961	9961	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of lung_resistance-related_protein -LRB- LRP -RRB- in initial and relapsed childhood acute_lymphoblastic_leukemia .
9436635	0	LRP	47,50	lung_resistance-related_protein	14,45	LRP	lung resistance-related protein	9961	9961	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of lung_resistance-related_protein -LRB- LRP -RRB- in non-small_cell_lung_carcinomas of smokers and non-smokers and its predictive value for doxorubicin_resistance .
9778689	0	LRP	18,21	lung_resistance-related_protein	23,54	LRP	lung resistance-related protein	9961	9961	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Activation of the LRP -LRB- lung_resistance-related_protein -RRB- gene by short-term exposure of human leukemia cells to phorbol_ester and cytarabine .
10697509	0	LRP	43,46	lung_resistance_protein	18,41	LRP	lung resistance protein	9961	9961	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the lung_resistance_protein -LRB- LRP -RRB- in primary breast_cancer .
15591119	0	LRP	109,112	platelet_factor_4	83,100	LRP	platelet factor 4	4035	5196	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet_factor_4 through LRP in an NF-kappaB-dependent manner .
14623925	0	LRP-1	80,85	low-density_lipoprotein_receptor-related_protein-1	28,78	LRP-1	low-density lipoprotein receptor-related protein-1	299858(Tax:10116)	299858(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of the low-density_lipoprotein_receptor-related_protein-1 -LRB- LRP-1 -RRB- in rats with prostate_cancer .
24392029	0	LRP-6	98,103	STAT3	122,127	LRP-6	STAT3	4040	6774	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Syndecan-1 -LRB- CD138 -RRB- modulates triple-negative breast_cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling .
11742004	0	LRP-6	88,93	dishevelled	111,122	LRP-6	dishevelled	16974(Tax:10090)	13542(Tax:10090)	Gene	Gene	independently|compound|START_ENTITY independently|nmod|END_ENTITY	Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled .
19371428	0	LRP1	0,4	ADAM10	39,45	LRP1	ADAM10	4035	102	Gene	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	LRP1 shedding in human brain : roles of ADAM10 and ADAM17 .
26464978	0	LRP1	0,4	BACE1	47,52	LRP1	BACE1	4035	23621	Gene	Gene	Downregulates|nsubj|START_ENTITY Downregulates|dobj|END_ENTITY	LRP1 Downregulates the Alzheimer 's b-Secretase BACE1 by Modulating Its Intraneuronal Trafficking -LRB- 1,2,3 -RRB- .
24947444	0	LRP1	24,28	FLVCR1	63,69	LRP1	FLVCR1	4035	28982	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status .
17376415	0	LRP1	86,90	LDL_receptor-related_protein	56,84	LRP1	LDL receptor-related protein	4035	4035	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sterol regulatory element binding proteins downregulate LDL_receptor-related_protein -LRB- LRP1 -RRB- expression and LRP1-mediated aggregated LDL uptake by human macrophages .
18281370	0	LRP1	57,61	LDL_receptor-related_protein	27,55	LRP1	LDL receptor-related protein	4035	4035	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II upregulates LDL_receptor-related_protein -LRB- LRP1 -RRB- expression in the vascular wall : a new pro-atherogenic mechanism of hypertension .
25238221	0	LRP1	70,74	lipoprotein_receptor-related_protein_1	30,68	LRP1	lipoprotein receptor-related protein 1	4035	4035	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Role of rs1466535 low density lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- gene polymorphism in carotid artery_disease .
12793904	0	LRP1	58,62	low-density_lipoprotein_receptor-related_protein_1	6,56	LRP1	low-density lipoprotein receptor-related protein 1	4035	4035	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	C766T low-density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- gene polymorphism and susceptibility to breast_cancer .
24139096	0	LRP1	132,136	low-density_lipoprotein_receptor-related_protein_1	80,130	LRP1	low-density lipoprotein receptor-related protein 1	4035	4035	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- expression .
20685197	0	LRP1	52,56	low-density_receptor-related_protein_1	12,50	LRP1	low-density receptor-related protein 1	4035	4035	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of low-density_receptor-related_protein_1 -LRB- LRP1 -RRB- as a competitive substrate of the amyloid_precursor_protein -LRB- APP -RRB- for BACE1 .
26164207	0	LRP1	86,90	plasminogen_activator_inhibitor-1	15,48	LRP1	plasminogen activator inhibitor-1	4035	5054	Gene	Gene	cells|nummod|START_ENTITY recruitment|nmod|cells regulates|dobj|recruitment regulates|nsubj|END_ENTITY	Glioma-derived plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- regulates the recruitment of LRP1 positive mast cells .
26555266	0	LRP1	134,138	plasminogen_activator_inhibitor-1	34,67	LRP1	plasminogen activator inhibitor-1	4035	5054	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The high-affinity binding site on plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- for the low density lipoprotein receptor-related protein -LRB- LRP1 -RRB- is composed of four basic residues .
19022849	0	LRP16	32,37	androgen_receptor	66,83	LRP16	androgen receptor	28992	367	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	The single-macro domain protein LRP16 is an essential cofactor of androgen_receptor .
12790785	0	LRP16	17,22	estrogen_receptor_alpha	70,93	LRP16	estrogen receptor alpha	28992	2099	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|proliferation proliferation|amod|17beta-estradiol 17beta-estradiol|nmod|activation activation|nmod|END_ENTITY	Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen_receptor_alpha -LRB- ERalpha -RRB- , but not ERbeta , and promotion of human breast_cancer MCF-7 cell proliferation : a preliminary report .
17914104	0	LRP16	25,30	estrogen_receptor_alpha	46,69	LRP16	estrogen receptor alpha	28992	2099	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Estrogenically regulated LRP16 interacts with estrogen_receptor_alpha and enhances the receptor 's transcriptional activity .
19403568	0	LRP16	26,31	estrogen_receptor_alpha	59,82	LRP16	estrogen receptor alpha	28992	2099	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Differential induction of LRP16 by liganded and unliganded estrogen_receptor_alpha in SKOV3 ovarian_carcinoma cells .
15172977	0	LRP1B	75,80	low_density_lipoprotein_receptor-related_protein_1B	22,73	LRP1B	low density lipoprotein receptor-related protein 1B	53353	53353	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Frequent silencing of low_density_lipoprotein_receptor-related_protein_1B -LRB- LRP1B -RRB- expression by genetic and epigenetic mechanisms in esophageal_squamous_cell_carcinoma .
18174661	0	LRP2	75,79	low-density_lipoprotein_receptor-related_protein_2	23,73	LRP2	low-density lipoprotein receptor-related protein 2	4036	4036	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Genetic association of low-density_lipoprotein_receptor-related_protein_2 -LRB- LRP2 -RRB- with plasma lipid levels .
18957220	0	LRP4	0,4	agrin	31,36	LRP4	agrin	4038	375790	Gene	Gene	serves|nsubj|START_ENTITY serves|nmod|coreceptor coreceptor|nmod|END_ENTITY	LRP4 serves as a coreceptor of agrin .
17319939	0	LRP4	118,122	low_density_lipoprotein_receptor-related_protein_4	61,111	LRP4	low density lipoprotein receptor-related protein 4	504317(Tax:9913)	504317(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Congenital_syndactyly in cattle : four novel mutations in the low_density_lipoprotein_receptor-related_protein_4 gene -LRB- LRP4 -RRB- .
12579474	0	LRP5	68,72	LDL_receptor-related_protein_5	36,66	LRP5	LDL receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Six novel missense mutations in the LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- gene in different conditions with an increased bone density .
14735475	0	LRP5	46,50	LDL_receptor-related_protein_5	14,44	LRP5	LDL receptor-related protein 5	4041	4041	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- as a novel marker for disease progression in high-grade osteosarcoma .
15824851	0	LRP5	62,66	LDL_receptor-related_protein_5	30,60	LRP5	LDL receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Heterozygous mutations in the LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with primary_osteoporosis in children .
24014470	0	LRP5	99,103	LDL_receptor-related_protein_5	67,97	LRP5	LDL receptor-related protein 5	4041	4041	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Pregnancy-associated_osteoporosis with a heterozygous deactivating LDL_receptor-related_protein_5 -LRB- LRP5 -RRB- mutation and a homozygous methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism .
19810105	0	LRP5	52,56	Low-density_lipoprotein_receptor-related_protein_5	0,50	LRP5	Low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- expression in human osteoarthritic chondrocytes .
15143163	0	LRP5	48,52	Mesd	70,74	LRP5	Mesd	4041	23184	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd .
20446724	0	LRP5	49,53	Mesd	0,4	LRP5	Mesd	4041	23184	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells .
21542013	0	LRP5	96,100	RUNX2	87,92	LRP5	RUNX2	4041	860	Gene	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Functional relevance of the BMD-associated polymorphism rs312009 : novel involvement of RUNX2 in LRP5 transcriptional regulation .
24058663	0	LRP5	12,16	VLDLR	20,25	LRP5	VLDLR	16973(Tax:10090)	22359(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Deletion of LRP5 in VLDLR knockout mice inhibits_retinal_neovascularization .
15077203	0	LRP5	73,77	low-density_lipoprotein_receptor-related_protein_5	21,71	LRP5	low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with variation in vertebral bone mass , vertebral bone size , and stature in whites .
15979013	0	LRP5	70,74	low-density_lipoprotein_receptor-related_protein_5	18,68	LRP5	low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotypes of the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene : are they a risk factor in osteoarthritis ?
16723389	0	LRP5	73,77	low-density_lipoprotein_receptor-related_protein_5	21,71	LRP5	low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with obesity phenotypes in a large family-based association study .
17306638	0	LRP5	118,122	low-density_lipoprotein_receptor-related_protein_5	61,111	LRP5	low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a single-nucleotide variation -LRB- A1330V -RRB- in the low-density_lipoprotein_receptor-related_protein_5 gene -LRB- LRP5 -RRB- with bone_mineral_density in adult Japanese women .
18058054	0	LRP5	73,77	low-density_lipoprotein_receptor-related_protein_5	21,71	LRP5	low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with peak bone mass in non-sedentary men : results from the Odense androgen study .
18073493	0	LRP5	67,71	low-density_lipoprotein_receptor-related_protein_5	15,65	LRP5	low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Association of low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- promoter SNP with peak bone_mineral_density in Chinese women .
19571442	0	LRP5	74,78	low-density_lipoprotein_receptor-related_protein_5	22,72	LRP5	low-density lipoprotein receptor-related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A1330V variant of the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene decreases Wnt signaling and affects the total body bone_mineral_density in Japanese women .
11793484	0	LRP5	95,99	low_density_lipoprotein_receptor_related_protein_5	43,93	LRP5	low density lipoprotein receptor related protein 5	4041	4041	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Seven novel sequence variants in the human low_density_lipoprotein_receptor_related_protein_5 -LRB- LRP5 -RRB- gene .
22000856	0	LRP5/6	68,74	Dickkopf	48,56	LRP5/6	Dickkopf	4041;4040	22943	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6 .
15778503	0	LRP5/6	20,26	Sclerostin	0,10	LRP5/6	Sclerostin	4041;4040	50964	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling .
12857724	0	LRP6	88,92	FZD5	81,85	LRP6	FZD5	312781(Tax:10116)	317674(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Functional characterization of WNT7A signaling in PC12 cells : interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins .
17376403	0	LRP6	15,19	GRB10	0,5	LRP6	GRB10	4040	2887	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	GRB10 binds to LRP6 , the Wnt co-receptor and inhibits canonical Wnt signaling pathway .
19107203	0	LRP6	74,78	GSK3beta	21,29	LRP6	GSK3beta	378494(Tax:8355)	399097(Tax:8355)	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling .
25500543	0	LRP6	69,73	KRAS	10,14	LRP6	KRAS	4040	3845	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Oncogenic KRAS signalling promotes the Wnt/b-catenin pathway through LRP6 in colorectal_cancer .
17400545	0	LRP6	41,45	LRP6	58,62	LRP6	LRP6	4040	4040	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling .
17400545	0	LRP6	58,62	LRP6	41,45	LRP6	LRP6	4040	4040	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling .
26239517	0	LRP6	65,69	miR-126	0,7	LRP6	miR-126	4040	406913	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-126 inhibits papillary_thyroid_carcinoma growth by targeting LRP6 .
27089893	0	LRP6	49,53	miR-29b	85,92	LRP6	miR-29b	4040	407024	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Posttranscriptional Regulation of Wnt-coreceptor LRP6 and RNA-binding Protein HuR by miR-29b in Intestinal Epithelial Cells .
26120271	0	LRP6	9,13	vascular_endothelial_growth_factor	36,70	LRP6	vascular endothelial growth factor	4040	7422	Gene	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	Elevated LRP6 levels correlate with vascular_endothelial_growth_factor in the vitreous of proliferative_diabetic_retinopathy .
20353975	0	LRP8	12,16	ApoER2	18,24	LRP8	ApoER2	7804	7804	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of LRP8 -LRB- ApoER2 ' -RRB- in the pathophysiology of the antiphospholipid_syndrome .
25299387	0	LRP8	61,65	F-spondin	0,9	LRP8	F-spondin	16975(Tax:10090)	233744(Tax:10090)	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	F-spondin Inhibits Differentiation of Clastic Precursors via LRP8 .
19497050	0	LRP9	16,20	Calnuc	0,6	LRP9	Calnuc	6653	4924	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Calnuc binds to LRP9 and affects its endosomal sorting .
25089713	0	LRPPRC	25,31	ABCB1	0,5	LRPPRC	ABCB1	10128	5243	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	ABCB1 regulation through LRPPRC is influenced by the methylation status of the GC -100 box in its promoter .
22326293	0	LRPPRC	72,78	leucine-rich_pentatricopeptide_repeat_motif-containing_protein	8,70	LRPPRC	leucine-rich pentatricopeptide repeat motif-containing protein	10128	10128	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of leucine-rich_pentatricopeptide_repeat_motif-containing_protein -LRB- LRPPRC -RRB- for anti-apoptosis and tumourigenesis in cancers .
21541782	0	LRR-RLK	77,84	Rhg4	66,70	LRR-RLK	Rhg4	547710(Tax:3847)	100286794(Tax:3847)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Soybean cyst nematode resistance in soybean is independent of the Rhg4 locus LRR-RLK gene .
26462420	0	LRRC31	0,6	IL-13	21,26	LRRC31	IL-13	79782	3596	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium .
20642442	1	LRRC32	54,60	GARP	48,52	LRRC32	GARP	2615	2615	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	the role of GARP -LRB- LRRC32 -RRB- as a safeguard of the regulatory phenotype .
19559015	0	LRRFIP1	20,27	MicroRNA-21	0,11	LRRFIP1	MicroRNA-21	9208	406991	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme .
23942110	0	LRRFIP2	0,7	NLRP3	29,34	LRRFIP2	NLRP3	9209	114548	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition .
25500533	0	LRRK2	19,24	ARHGEF7	112,119	LRRK2	ARHGEF7	66725(Tax:10090)	54126(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of LRRK2 by casein kinase 1a regulates trans-Golgi clustering via differential interaction with ARHGEF7 .
21658387	0	LRRK2	0,5	Akt1	30,34	LRRK2	Akt1	120892	207	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	LRRK2 directly phosphorylates Akt1 as a possible physiological substrate : impairment of the kinase activity by Parkinson 's _ disease-associated mutations .
20728949	0	LRRK2	0,5	B-2	22,25	LRRK2	B-2	66725(Tax:10090)	12062(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	LRRK2 is expressed in B-2 but not in B-1 B cells , and downregulated by cellular activation .
26930193	0	LRRK2	18,23	Cdk5	48,52	LRRK2	Cdk5	120892	1020	Gene	Gene	R1628P|compound|START_ENTITY Enables|nsubj|R1628P Enables|dobj|Phosphorylation Phosphorylation|compound|END_ENTITY	Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity .
26930193	0	LRRK2	72,77	Cdk5	48,52	LRRK2	Cdk5	120892	1020	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase Activity .
22652643	0	LRRK2	40,45	GST_P1	0,6	LRRK2	GST P1	120892	2950	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	GST_P1 , a novel downstream regulator of LRRK2 , G2019S-induced neuronal cell death .
24479685	0	LRRK2	48,53	Interferon-y	0,12	LRRK2	Interferon-y	120892	3458	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interferon-y induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages .
24014121	0	LRRK2	71,76	Leucine-Rich_repeat_kinase_2	41,69	LRRK2	Leucine-Rich repeat kinase 2	120892	120892	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Patient-control association study of the Leucine-Rich_repeat_kinase_2 -LRB- LRRK2 -RRB- gene in South African Parkinson 's _ disease patients .
26375402	0	LRRK2	0,5	PAK6	21,25	LRRK2	PAK6	120892	56924	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LRRK2 interacts with PAK6 to control neurite complexity in mammalian brain .
17804834	0	LRRK2	0,5	PARK8	82,87	LRRK2	PARK8	120892	120892	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|END_ENTITY	LRRK2 mutation analysis in Parkinson_disease families with evidence of linkage to PARK8 .
23395371	0	LRRK2	22,27	RAB7L1	0,6	LRRK2	RAB7L1	120892	8934	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson 's _ disease risk .
23949442	0	LRRK2	0,5	Snapin	21,27	LRRK2	Snapin	300160(Tax:10116)	295217(Tax:10116)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25 .
27004687	0	LRRK2	14,19	Sp1	61,64	LRRK2	Sp1	120892	6667	Gene	Gene	Regulation|nmod|START_ENTITY promoter|nsubj|Regulation promoter|nmod|END_ENTITY	Regulation of LRRK2 promoter activity and gene expression by Sp1 .
18496192	0	LRRK2	104,109	dardarin	110,118	LRRK2	dardarin	120892	120892	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Outcome of bilateral deep brain subthalamic stimulation in patients carrying the R1441G mutation in the LRRK2 dardarin gene .
20403420	0	LRRK2	44,49	leucine-rich-repeat-kinase_2	14,42	LRRK2	leucine-rich-repeat-kinase 2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of leucine-rich-repeat-kinase_2 -LRB- LRRK2 -RRB- during embryonic development .
21088684	0	LRRK2	42,47	leucine-rich_repeat_kinase_2	12,40	LRRK2	leucine-rich repeat kinase 2	120892	120892	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- in Parkinson 's _ disease .
21806997	0	LRRK2	57,62	leucine-rich_repeat_kinase_2	27,55	LRRK2	leucine-rich repeat kinase 2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Autophosphorylation in the leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- GTPase domain modifies kinase and GTP-binding activities .
21972245	0	LRRK2	91,96	leucine-rich_repeat_kinase_2	61,89	LRRK2	leucine-rich repeat kinase 2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional responses to loss or gain of function of the leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- gene uncover biological processes modulated by LRRK2 activity .
22703868	0	LRRK2	94,99	leucine-rich_repeat_kinase_2	64,92	LRRK2	leucine-rich repeat kinase 2	120892	120892	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Dyskinesias in patients with Parkinson 's _ disease : effect of the leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- G2019S mutation .
17447891	0	LRRK2	0,5	moesin	21,27	LRRK2	moesin	300160(Tax:10116)	81521(Tax:10116)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	LRRK2 phosphorylates moesin at threonine-558 : characterization of how Parkinson 's _ disease mutants affect kinase activity .
20434426	0	LRRK2	73,78	moesin	109,115	LRRK2	moesin	120892	4478	Gene	Gene	measuring|dobj|START_ENTITY assay|acl|measuring Development|nmod|assay kinase|nsubj|Development kinase|dobj|activity activity|acl|using using|dobj|substrate substrate|amod|END_ENTITY	Development of a high-throughput AlphaScreen assay measuring full-length LRRK2 -LRB- G2019S -RRB- kinase activity using moesin protein substrate .
20064388	0	LRRTM2	0,6	Neurexin1	22,31	LRRTM2	Neurexin1	26045	9378	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation .
17098871	0	LRRTM3	0,6	BACE1	59,64	LRRTM3	BACE1	347731	23621	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer 's _ disease .
25624497	0	LRRTM4	61,67	glypican-4	50,60	LRRTM4	glypican-4	500219(Tax:10116)	317322(Tax:10116)	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	PTP functions as a presynaptic receptor for the glypican-4 / LRRTM4 complex and is essential for excitatory synaptic transmission .
23275029	0	LRWD1	142,147	Leucine-Rich_Repeats_and_WD_Repeat_Domain_Containing_1	86,140	LRWD1	Leucine-Rich Repeats and WD Repeat Domain Containing 1	222229	222229	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Nuclear Factor - _ # 954 ; B -LRB- NF - _ # 954 ; B -RRB- Regulates the Expression of Human Testis-Enriched Leucine-Rich_Repeats_and_WD_Repeat_Domain_Containing_1 -LRB- LRWD1 -RRB- Gene .
25580204	0	LSD1	71,75	KDM1A	77,82	LSD1	KDM1A	23028	23028	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	3,5-Diamino-1 ,2,4 - triazoles as a novel scaffold for potent , reversible LSD1 -LRB- KDM1A -RRB- inhibitors .
22920283	0	LSD1	23,27	Lysine-specific_demethylase_1	29,58	LSD1	Lysine-specific demethylase 1	23028	23028	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elevated expression of LSD1 -LRB- Lysine-specific_demethylase_1 -RRB- during tumour progression from pre-invasive to invasive ductal_carcinoma_of_the_breast .
24687155	0	LSD1	79,83	Lysine_Specific_Demethylase_1	48,77	LSD1	Lysine Specific Demethylase 1	23028	23028	Gene	Gene	Assay|appos|START_ENTITY Assay|nmod|END_ENTITY	Heterogeneous Antibody-Based Activity Assay for Lysine_Specific_Demethylase_1 -LRB- LSD1 -RRB- on a Histone Peptide Substrate .
27027352	0	LSD1	85,89	NCALD	120,125	LSD1	NCALD	23028	83988	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell_lung_cancer .
25285406	0	LSD1	0,4	PXN	79,82	LSD1	PXN	99982(Tax:10090)	19303(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	LSD1 controls metastasis of androgen-independent prostate_cancer cells through PXN and LPAR6 .
23626788	0	LSD1	30,34	Prox1	0,5	LSD1	Prox1	23028	5629	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription .
23592795	0	LSD1	22,26	SFMBT1	0,6	LSD1	SFMBT1	23028	51460	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors .
25036127	0	LSD1	108,112	TFPI-2	49,55	LSD1	TFPI-2	23028	7980	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
18391013	0	LSD1	65,69	TLX	28,31	LSD1	TLX	23028	4179	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|function function|nmod|END_ENTITY	Transrepressive function of TLX requires the histone demethylase LSD1 .
24075993	0	LSD1	36,40	USP28	19,24	LSD1	USP28	23028	57646	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast_cancer cells .
23508577	0	LSD1	120,124	lysine-specific_demethylase-1	89,118	LSD1	lysine-specific demethylase-1	23028	23028	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific_demethylase-1 -LRB- LSD1 -RRB- inhibitor in human acute_myeloid_leukemia cell lines .
24165091	0	LSD1	57,61	lysine-specific_demethylase_1	26,55	LSD1	lysine-specific demethylase 1	23028	23028	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Analysis of the levels of lysine-specific_demethylase_1 -LRB- LSD1 -RRB- mRNA in human ovarian_tumors and the effects of chemical LSD1 inhibitors in ovarian_cancer cell lines .
25036127	0	LSD1	108,112	lysine-specific_demethylase_1	71,100	LSD1	lysine-specific demethylase 1	23028	23028	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
27062244	0	LSD1	50,54	lysine-specific_demethylase_1	19,48	LSD1	lysine-specific demethylase 1	99982(Tax:10090)	99982(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Tranylcypromine , a lysine-specific_demethylase_1 -LRB- LSD1 -RRB- inhibitor , suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis .
26833707	0	LSD1	8,12	miR-708	0,7	LSD1	miR-708	23028	100126333	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	miR-708 / LSD1 axis regulates the proliferation and invasion of breast_cancer cells .
17805299	0	LSD1	43,47	p53	0,3	LSD1	p53	23028	7157	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	p53 is regulated by the lysine demethylase LSD1 .
23072722	0	LSD1	8,12	p53	123,126	LSD1	p53	23028	7157	Gene	Gene	Loss|nmod|START_ENTITY suppresses|nsubj|Loss suppresses|dobj|expression expression|nmod|cells cells|nmod|END_ENTITY	Loss of LSD1 -LRB- lysine-specific_demethylase_1 -RRB- suppresses growth and alters gene expression of human colon_cancer cells in a p53 - and DNMT1 -LRB- DNA_methyltransferase_1 -RRB- - independent manner .
25036127	0	LSD1	108,112	tissue_factor_pathway_inhibitor-2	14,47	LSD1	tissue factor pathway inhibitor-2	23028	7980	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
20127679	0	LSECtin	26,33	CD44	55,59	LSECtin	CD44	339390	960	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	The DC-SIGN family member LSECtin is a novel ligand of CD44 on activated T cells .
15254976	0	LSH	53,56	TP53	86,90	LSH	TP53	3070	7157	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	TP53 in gastric_cancer : mutations in the l3 loop and LSH motif DNA-binding domains of TP53 predict poor outcome .
9890705	0	LSP1	59,63	lymphocyte-specific_protein_1	28,57	LSP1	lymphocyte-specific protein 1	4046	4046	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Developmental regulation of lymphocyte-specific_protein_1 -LRB- LSP1 -RRB- expression in thymus during human T-cell maturation .
8995217	0	LSP1	0,4	mitogen-activated_protein_kinase-activated_protein_kinase_2	32,91	LSP1	mitogen-activated protein kinase-activated protein kinase 2	4046	9261	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	LSP1 is the major substrate for mitogen-activated_protein_kinase-activated_protein_kinase_2 in human neutrophils .
11137562	0	LSP1	71,75	pp52	65,69	LSP1	pp52	4046	4046	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Aberrant expression and localization of the cytoskeleton-binding pp52 -LRB- LSP1 -RRB- protein in hairy_cell_leukemia .
11368895	0	LSP1	43,47	pp52	37,41	LSP1	pp52	4046	4046	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Leukocyte-specific expression of the pp52 -LRB- LSP1 -RRB- promoter is controlled by the cis-acting pp52 silencer and anti-silencer elements .
10330397	0	LST1	0,4	SEC24	10,15	LST1	SEC24	856498(Tax:4932)	854697(Tax:4932)	Gene	Gene	homologue|nsubj|START_ENTITY homologue|compound|END_ENTITY	LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum .
20431118	0	LSY-22	74,80	UNC-37	21,27	LSY-22	UNC-37	172536(Tax:6239)	172394(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. _ elegans .
11164894	0	LT-alpha	37,45	HveA	82,86	LT-alpha	HveA	4049	8764	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	The three HveA receptor ligands , gD , LT-alpha and LIGHT bind to distinct sites on HveA .
12474234	0	LT-beta	32,39	lymphotoxin-beta	14,30	LT-beta	lymphotoxin-beta	4050	4050	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of lymphotoxin-beta -LRB- LT-beta -RRB- in chronic inflammatory conditions .
21482522	0	LTA	46,49	lymphotoxin-alpha	27,44	LTA	lymphotoxin-alpha	4049	4049	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Identification of a novel lymphotoxin-alpha -LRB- LTA -RRB- gene associated with ankylosing_spondylitis in Ningxia population -RSB- .
6258182	0	LTB4	30,34	leukotriene_B4	14,28	LTB4	leukotriene B4	100135572(Tax:10141)	100135572(Tax:10141)	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	The action of leukotriene_B4 -LRB- LTB4 -RRB- on the lung .
14762110	0	LTBP-1	76,82	latent_transforming_growth_factor-beta_binding_protein_1	18,74	LTBP-1	latent transforming growth factor-beta binding protein 1	268977(Tax:10090)	268977(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of latent_transforming_growth_factor-beta_binding_protein_1 -LRB- LTBP-1 -RRB- in dioxin receptor-null mouse embryo fibroblasts .
25858550	0	LTBP-1	54,60	transforming_growth_factor-b	7,35	LTBP-1	transforming growth factor-b	4052	7040	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	Latent transforming_growth_factor-b binding proteins -LRB- LTBP-1 and LTBP-2 -RRB- and gingiva keratinization .
25858550	0	LTBP-1	54,60	transforming_growth_factor-b	7,35	LTBP-1	transforming growth factor-b	4052	7040	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	Latent transforming_growth_factor-b binding proteins -LRB- LTBP-1 and LTBP-2 -RRB- and gingiva keratinization .
24148803	0	LTBP-2	0,6	tropoelastin	21,33	LTBP-2	tropoelastin	4053	2006	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin , and is a negative modulator of elastinogenesis .
16223572	0	LTBP-3	19,25	TGF-beta1	47,56	LTBP-3	TGF-beta1	4054	7040	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements .
10025676	0	LTBP1	32,37	TGF-beta1	49,58	LTBP1	TGF-beta1	59107(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Vitamin_D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes .
25528440	0	LTBP1	96,101	c-Myc	77,82	LTBP1	c-Myc	4052	4609	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	Marek * _ s_disease_virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-b signaling pathway .
25669657	0	LTBP3	52,57	latent_TGF-beta_binding_protein_3	17,50	LTBP3	latent TGF-beta binding protein 3	16998(Tax:10090)	16998(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the latent_TGF-beta_binding_protein_3 -LRB- LTBP3 -RRB- gene cause brachyolmia with amelogenesis_imperfecta .
7949732	0	LTF	29,32	lactoferrin	11,22	LTF	lactoferrin	280846(Tax:9913)	280846(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The bovine lactoferrin gene -LRB- LTF -RRB- maps to chromosome 22 and syntenic group U12 .
11960981	0	LTRPC2	78,84	long_transient_receptor_potential_channel_2	33,76	LTRPC2	long transient receptor potential channel 2	7226	7226	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of the cation channel long_transient_receptor_potential_channel_2 -LRB- LTRPC2 -RRB- by hydrogen_peroxide .
9354470	0	LTbeta	40,46	CD3	35,38	LTbeta	CD3	16994(Tax:10090)	12501(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|dep|cells	Developing lymph nodes collect CD4 + CD3 - LTbeta + cells that can differentiate to APC , NK cells , and follicular cells but not T or B cells .
18230648	0	LUMA	0,4	emerin	20,26	LUMA	emerin	79188	2010	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	LUMA interacts with emerin and influences its distribution at the inner nuclear membrane .
20546900	0	LUMAN	57,62	DC-STAMP	0,8	LUMAN	DC-STAMP	10488	81501	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation .
10924356	0	LXR	77,80	ABC1	0,4	LXR	ABC1	22259(Tax:10090)	11303(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR .
12777468	0	LXR	125,128	ABCG5	25,30	LXR	ABCG5	22259(Tax:10090)	27409(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages : differential role of LXR .
18242221	0	LXR	58,61	Cd36	31,35	LXR	Cd36	22259(Tax:10090)	12491(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Hepatic fatty_acid transporter Cd36 is a common target of LXR , PXR , and PPARgamma in promoting steatosis .
20837115	0	LXR	24,27	LPCAT3	14,20	LXR	LPCAT3	395221(Tax:9031)	418293(Tax:9031)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of LPCAT3 by LXR .
25084760	0	LXR	74,77	Liver_X_Receptor	56,72	LXR	Liver X Receptor	22259(Tax:10090)	22259(Tax:10090)	Gene	Gene	Pathway|appos|START_ENTITY Pathway|compound|END_ENTITY	Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver_X_Receptor -LRB- LXR -RRB- Pathway by Activating Small Guanosine_Triphosphate-Binding Proteins -LRB- sGTPases -RRB- in Neuronal Cells .
12518032	0	LXR	54,57	angiopoietin-like_protein_3	18,45	LXR	angiopoietin-like protein 3	22259(Tax:10090)	30924(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of the angiopoietin-like_protein_3 gene by LXR .
19416695	0	LXR	73,76	liver_X_receptor	55,71	LXR	liver X receptor	100270809(Tax:8030)	100270809(Tax:8030)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Molecular cloning , tissue expression and regulation of liver_X_receptor -LRB- LXR -RRB- transcription factors of Atlantic_salmon -LRB- Salmo_salar -RRB- and rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
17177110	0	LXR_alpha	0,9	organic_solute_transporter_alpha	31,63	LXR alpha	organic solute transporter alpha	22259(Tax:10090)	106407(Tax:10090)	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	LXR_alpha transactivates mouse organic_solute_transporter_alpha and beta via IR-1 elements shared with FXR .
25661920	0	LXRa	44,48	CCAR2	0,5	LXRa	CCAR2	10062	57805	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	CCAR2 negatively regulates nuclear receptor LXRa by competing with SIRT1 deacetylase .
22503545	0	LXRa	76,80	PAPP-A	0,6	LXRa	PAPP-A	10062	5069	Gene	Gene	inhibiting|dobj|START_ENTITY regulates|advcl|inhibiting regulates|nsubj|END_ENTITY	PAPP-A negatively regulates ABCA1 , ABCG1 and SR-B1 expression by inhibiting LXRa through the IGF-I-mediated signaling pathway .
20871621	0	LXRa	47,51	THP-1	73,78	LXRa	THP-1	10062	2736	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Ibrolipim increases ABCA1/G1 expression by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
23564066	0	LXRa	68,72	THP-1	94,99	LXRa	THP-1	10062	2736	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
24751522	0	LXRa	50,54	THP-1	84,89	LXRa	THP-1	10062	2736	Gene	Gene	START_ENTITY|nmod|macrophages macrophages|compound|END_ENTITY	miR-613 regulates cholesterol efflux by targeting LXRa and ABCA1 in PPARy activated THP-1 macrophages .
26261553	0	LXRa	72,76	THP-1	98,103	LXRa	THP-1	10062	2736	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Lipoxin_A4 promotes ABCA1 expression and cholesterol efflux through the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
24603323	0	LXRa	17,21	miR-206	0,7	LXRa	miR-206	10062	406989	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	miR-206 controls LXRa expression and promotes LXR-mediated cholesterol efflux in macrophages .
24751522	0	LXRa	50,54	miR-613	0,7	LXRa	miR-613	10062	693198	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-613 regulates cholesterol efflux by targeting LXRa and ABCA1 in PPARy activated THP-1 macrophages .
18562803	0	LXRalpha	24,32	CETP	50,54	LXRalpha	CETP	10062	1071	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|promoter promoter|compound|END_ENTITY	FXRalpha down-regulates LXRalpha signaling at the CETP promoter via a common element .
20494359	0	LXRalpha	0,8	CETP	25,29	LXRalpha	CETP	10062	1071	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	LXRalpha regulates human CETP expression in vitro and in transgenic_mice .
16489206	0	LXRalpha	79,87	CYP7A1	115,121	LXRalpha	CYP7A1	100352900(Tax:9986)	100328551(Tax:9986)	Gene	Gene	site|compound|START_ENTITY site|nmod|promoter promoter|compound|END_ENTITY	The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a LXRalpha binding site in the rabbit CYP7A1 promoter .
19229075	0	LXRalpha	28,36	FGF-1	0,5	LXRalpha	FGF-1	58852(Tax:10116)	25317(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes .
17054913	0	LXRalpha	14,22	VDR	73,76	LXRalpha	VDR	58852(Tax:10116)	24873(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of LXRalpha signaling by vitamin_D_receptor : possible role of VDR in bile_acid synthesis .
17054913	0	LXRalpha	14,22	vitamin_D_receptor	36,54	LXRalpha	vitamin D receptor	58852(Tax:10116)	24873(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Inhibition of LXRalpha signaling by vitamin_D_receptor : possible role of VDR in bile_acid synthesis .
12393874	0	LXRbeta	54,61	ALK-1	14,19	LXRbeta	ALK-1	7376	94	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of ALK-1 signaling by the nuclear receptor LXRbeta .
1680927	0	LY-49	54,59	NKR-P1	22,28	LY-49	NKR-P1	17055(Tax:10090)	17059(Tax:10090)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49 .
25313399	0	LY5	41,44	STAT3	24,29	LY5	STAT3	5788	6774	Gene	Gene	Viability|compound|START_ENTITY Inhibitor|appos|Viability Inhibitor|compound|END_ENTITY	A Novel Small Molecular STAT3 Inhibitor , LY5 Inhibits Cell Viability , Cell Migration , And Angiogenesis in Medulloblastoma Cells .
26883202	0	LY5	40,43	STAT3	23,28	LY5	STAT3	5788	6774	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel small molecule STAT3 inhibitor , LY5 , inhibits cell viability , colony_formation , _ and_migration_of_colon_and_liver_cancer cells .
16964412	0	LY52	38,42	matrix_metalloproteinase-2	69,95	LY52	matrix metalloproteinase-2	12484(Tax:10090)	4313	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Using caffeoyl_pyrrolidine derivative LY52 , a potential inhibitor of matrix_metalloproteinase-2 , to suppress tumor invasion and metastasis .
15930324	0	LY6A/E	0,6	SCA-1	8,13	LY6A/E	SCA-1	110454(Tax:10090)	110454(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	LY6A/E -LRB- SCA-1 -RRB- expression in the mouse testis .
21390520	0	LY96	0,4	CD14	32,36	LY96	CD14	23643	929	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	LY96 , UPKIB mutations and TLR4 , CD14 , MBL polymorphisms in children with urinary_tract_infection .
24971461	0	LY96	66,70	TLR4	54,58	LY96	TLR4	23643	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
22172515	0	LYCAT	0,5	acl-8	33,38	LYCAT	acl-8	225010(Tax:10090)	179031(Tax:6239)	Gene	Gene	START_ENTITY|appos|homologue homologue|amod|END_ENTITY	LYCAT , a homologue of C. _ elegans acl-8 , acl-9 , and acl-10 , determines the fatty_acid composition of phosphatidylinositol in mice .
15896657	0	LYST	16,20	CHS1	10,14	LYST	CHS1	1130	1130	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Two novel CHS1 -LRB- LYST -RRB- mutations : clinical correlations in an infant with Chediak-Higashi_syndrome .
17468262	0	LYST-INTERACTING_PROTEIN5	122,147	SKD1	27,31	LYST-INTERACTING PROTEIN5	SKD1	828782(Tax:3702)	817306(Tax:3702)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The Arabidopsis AAA ATPase SKD1 is involved in multivesicular endosome function and interacts with its positive regulator LYST-INTERACTING_PROTEIN5 .
19170073	0	LYVE-1	38,44	CD44	45,49	LYVE-1	CD44	114332(Tax:10090)	12505(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Lack of lymphatic vessel phenotype in LYVE-1 / CD44 double knockout mice .
26116468	0	LYVE-1	34,40	S1P3	24,28	LYVE-1	S1P3	10894	1903	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The cooperative role of S1P3 with LYVE-1 in LMW-HA-induced lymphangiogenesis .
25270205	0	LYVE-1	46,52	Vascular_endothelial_growth_factor_C	1,37	LYVE-1	Vascular endothelial growth factor C	10894	7424	Gene	Gene	cells|amod|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	-LSB- Vascular_endothelial_growth_factor_C induces LYVE-1 -LRB- + -RRB- endothelial cells to reconstruct hepatic sinusoid during liver regeneration -RSB- .
16569201	0	LYVE-1	68,74	lymphatic_vascular_endothelial_hyaluronan_receptor-1	14,66	LYVE-1	lymphatic vascular endothelial hyaluronan receptor-1	10894	10894	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of lymphatic_vascular_endothelial_hyaluronan_receptor-1 -LRB- LYVE-1 -RRB- in the human placenta .
24745549	0	LYZL6	14,19	c-type_lysozyme	35,50	LYZL6	c-type lysozyme	57151	4069	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of LYZL6 , a novel human c-type_lysozyme , in recombinant Pichia_pastoris employing high cell density fed-batch fermentation .
15001559	0	LZIP	6,10	CCR1	20,24	LZIP	CCR1	10488	1230	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines .
18587271	0	LZIP	6,10	CC_chemokine_receptor_2	28,51	LZIP	CC chemokine receptor 2	10488	729230	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Human LZIP induces monocyte CC_chemokine_receptor_2 expression leading to enhancement of monocyte_chemoattractant_protein_1 / CCL2-induced cell migration .
12186766	0	LZK	82,85	leucine_zipper-bearing_kinase	51,80	LZK	leucine zipper-bearing kinase	9175	9175	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and fine-mapping of the human leucine_zipper-bearing_kinase -LRB- LZK -RRB- gene .
23692385	0	LZTFL1	80,86	BBS17	88,93	LZTFL1	BBS17	54585	1194524(Tax:224326)	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Mesoaxial polydactyly is a major feature in Bardet-Biedl_syndrome patients with LZTFL1 -LRB- BBS17 -RRB- mutations .
25813822	0	LZTS1	52,57	Leucine_Zipper_Putative_Tumor_Suppressor_1	8,50	LZTS1	Leucine Zipper Putative Tumor Suppressor 1	11178	11178	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Loss of Leucine_Zipper_Putative_Tumor_Suppressor_1 -LRB- LZTS1 -RRB- Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary_Carcinoma .
24802407	0	LZTS1	100,105	miR-214	0,7	LZTS1	miR-214	11178	406996	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1 .
9003378	0	Lactoferrin	0,11	chymase	75,82	Lactoferrin	chymase	301034(Tax:10116)	29265(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Lactoferrin regulates the activity of heparin proteoglycan-bound mast cell chymase : characterization of the binding of heparin to lactoferrin .
2670003	0	Lactoferrin	0,11	colony_stimulating_factor	23,48	Lactoferrin	colony stimulating factor	17002(Tax:10090)	12981(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Lactoferrin stimulates colony_stimulating_factor production in vitro and in vivo .
24562308	0	Lactoferrin	0,11	insulin-like_growth_factor_I	39,67	Lactoferrin	insulin-like growth factor I	301034(Tax:10116)	24482(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Lactoferrin inhibits apoptosis through insulin-like_growth_factor_I in primary rat osteoblasts .
9279212	0	Lactoferrin	0,11	tryptase	22,30	Lactoferrin	tryptase	554321(Tax:9940)	443433(Tax:9940)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Lactoferrin , a potent tryptase inhibitor , abolishes late-phase airway responses in allergic sheep .
21153198	0	Lactogen	0,8	Nb2	18,21	Lactogen	Nb2	1443	53942	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Lactogen enhances Nb2 cell GTPase activity after 4 hours incubation .
11463744	0	Laloo	90,95	FRS2	8,12	Laloo	FRS2	373700(Tax:8355)	380490(Tax:8355)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Xenopus FRS2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo .
11526510	0	Laloo	14,19	Xcsk	58,62	Laloo	Xcsk	373700(Tax:8355)	378532(Tax:8355)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of Laloo by the Xenopus C-terminal_Src_kinase -LRB- Xcsk -RRB- during early vertebrate development .
9403717	0	LamC1	32,37	laminin-gamma1	77,91	LamC1	laminin-gamma1	3915	39118(Tax:7227)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Sp1-mediated transactivation of LamC1 promoter and coordinated expression of laminin-gamma1 and Sp1 in human hepatocellular_carcinomas .
26598132	0	LamR	24,28	Gelsolin	0,8	LamR	Gelsolin	3921	2934	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Gelsolin interacts with LamR , hnRNP_U , nestin , Arp3 and b-tubulin in human melanoma cells as revealed by immunoprecipitation and mass spectrometry .
7874173	0	Lama2	71,76	laminin_alpha_2	54,69	Lama2	laminin alpha 2	16773(Tax:10090)	16773(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Murine muscular_dystrophy caused by a mutation in the laminin_alpha_2 -LRB- Lama2 -RRB- gene .
9735344	0	Lama5	14,19	Ra	57,59	Lama5	Ra	16776(Tax:10090)	20672(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Evaluation of Lama5 as a candidate for the mouse ragged -LRB- Ra -RRB- mutation .
20826821	0	Lamin_B	0,7	Eg5	32,35	Lamin B	Eg5	379745(Tax:8355)	397908(Tax:8355)	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	Lamin_B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly .
11035933	0	Laminin-1	0,9	Cdc42	20,25	Laminin-1	Cdc42	316758(Tax:10116)	64465(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Laminin-1 activates Cdc42 in the mechanism of laminin-1-mediated neurite outgrowth .
25761317	0	Lan	16,19	Lan	31,34	Lan	Lan	9993	9993	Gene	Gene	antigen|compound|START_ENTITY antigen|nmod|+ +|compound|END_ENTITY	Quantitation of Lan antigen in Lan + , Lan + -LRB- w -RRB- and Lan - phenotypes .
25761317	0	Lan	31,34	Lan	16,19	Lan	Lan	9993	9993	Gene	Gene	+|compound|START_ENTITY antigen|nmod|+ antigen|compound|END_ENTITY	Quantitation of Lan antigen in Lan + , Lan + -LRB- w -RRB- and Lan - phenotypes .
19293638	0	Langerhans_cell_protein_1	0,25	PNUTS	42,47	Langerhans cell protein 1	PNUTS	3936	5514	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Langerhans_cell_protein_1 -LRB- LCP1 -RRB- binds to PNUTS in the nucleus : implications for this complex in transcriptional regulation .
12884872	0	Langerin	36,44	CD207	46,51	Langerin	CD207	50489	50489	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	TNF-alpha induces the generation of Langerin / -LRB- CD207 -RRB- + immature Langerhans-type dendritic cells from both CD14-CD1a and CD14 + CD1a - precursors derived from CD34 + cord blood cells .
22167195	0	Late_SV40_factor	0,16	matrix_metalloproteinase-9	80,106	Late SV40 factor	matrix metalloproteinase-9	7024	4318	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Late_SV40_factor -LRB- LSF -RRB- enhances angiogenesis by transcriptionally up-regulating matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- .
18490732	0	Latency-associated_peptide	0,26	CD4	46,49	Latency-associated peptide	CD4	7040	920	Gene	Gene	identifies|nsubj|START_ENTITY identifies|dobj|subset subset|compound|END_ENTITY	Latency-associated_peptide identifies a novel CD4 + CD25 + regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis .
18926796	0	Latent_membrane_protein-1	0,25	B-cell_integration_cluster	74,100	Latent membrane protein-1	B-cell integration cluster	9260	114614	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Latent_membrane_protein-1 of Epstein-Barr_virus induces the expression of B-cell_integration_cluster , a precursor form of microRNA-155 , in B_lymphoma cell lines .
7636179	0	Latent_membrane_protein-1	0,25	cyclin_D2	34,43	Latent membrane protein-1	cyclin D2	9260	894	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Latent_membrane_protein-1 induces cyclin_D2 expression , pRb hyperphosphorylation , and loss of TGF-beta_1-mediated growth inhibition in EBV-positive B cells .
12857898	0	Latent_membrane_protein_1	0,25	CD83	56,60	Latent membrane protein 1	CD83	9260	9308	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Latent_membrane_protein_1 of Epstein-Barr_virus induces CD83 by the NF-kappaB signaling pathway .
12857898	0	Latent_membrane_protein_1	0,25	NF-kappaB	68,77	Latent membrane protein 1	NF-kappaB	9260	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Latent_membrane_protein_1 of Epstein-Barr_virus induces CD83 by the NF-kappaB signaling pathway .
17099724	0	Latent_membrane_protein_1	0,25	RASSF1A	37,44	Latent membrane protein 1	RASSF1A	9260	11186	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Latent_membrane_protein_1 suppresses RASSF1A expression , disrupts microtubule structures and induces chromosomal_aberrations in human epithelial cells .
15795279	0	Latent_membrane_protein_1	0,25	STAT1	36,41	Latent membrane protein 1	STAT1	9260	6772	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Latent_membrane_protein_1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr_virus-immortalized B cells .
15777619	0	Lats1	46,51	large_tumor_suppressor_gene	17,44	Lats1	large tumor suppressor gene	9113	9113	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Two forms of the large_tumor_suppressor_gene -LRB- Lats1 -RRB- protein expressed in the vertebrate retina .
15147269	0	Lats2	24,29	Aurora-A_kinase	61,76	Lats2	Aurora-A kinase	26524	6790	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The centrosomal protein Lats2 is a phosphorylation target of Aurora-A_kinase .
8921873	0	Lcb2	92,96	serine_palmitoyltransferase	108,135	Lcb2	serine palmitoyltransferase	9517	189	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Sphingolipid synthesis : identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine_palmitoyltransferase .
11983176	0	Lcd1p	0,5	Mec1p	15,20	Lcd1p	Mec1p	7045	545	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo .
16116473	0	Lck	20,23	Bak	102,105	Lck	Bak	3932	578	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|pathway pathway|nmod|expression expression|compound|END_ENTITY	The tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expression .
16186791	0	Lck	21,24	Bak	26,29	Lck	Bak	3932	578	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	A novel link between Lck , Bak expression and chemosensitivity .
18371298	0	Lck	14,17	Bak	94,97	Lck	Bak	3932	578	Gene	Gene	Activation|nmod|START_ENTITY required|nsubjpass|Activation required|nmod|activation activation|nmod|END_ENTITY	Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death .
10843386	0	Lck	70,73	CD4	100,103	Lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY reveals|dobj|role reveals|nmod|differentiation differentiation|nmod|thymocytes thymocytes|compound|END_ENTITY	Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes .
11828322	0	Lck	14,17	CD4	30,33	Lck	CD4	3932	920	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of Lck activity by CD4 and CD28 in the immunological synapse .
12517957	0	Lck	82,85	CD4	27,30	Lck	CD4	3932	920	Gene	Gene	palmitoylation|nmod|START_ENTITY depends|nmod|palmitoylation depends|nsubj|distribution distribution|nmod|END_ENTITY	Lipid raft distribution of CD4 depends on its palmitoylation and association with Lck , and evidence for CD4-induced lipid raft aggregation as an additional mechanism to enhance CD3 signaling .
15247914	0	Lck	59,62	CD4	0,3	Lck	CD4	3932	920	Gene	Gene	accumulation|compound|START_ENTITY coordinating|dobj|accumulation enhances|advcl|coordinating enhances|nsubj|END_ENTITY	CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse .
16631599	0	Lck	78,81	CD4	26,29	Lck	CD4	3932	920	Gene	Gene	p56|appos|START_ENTITY dissociation|nmod|p56 END_ENTITY|nmod|dissociation	Lipoic_acid downmodulates CD4 from human T lymphocytes by dissociation of p56 -LRB- Lck -RRB- .
18031691	0	Lck	29,32	CD4	0,3	Lck	CD4	3932	920	Gene	Gene	hogging|dobj|START_ENTITY END_ENTITY|parataxis|hogging	CD4 and CD8 : hogging all the Lck .
19019957	0	Lck	61,64	CD4	18,21	Lck	CD4	3932	920	Gene	Gene	redistribution|nmod|START_ENTITY affects|dobj|redistribution affects|nsubj|Engagement Engagement|nmod|receptor receptor|compound|END_ENTITY	Engagement of the CD4 receptor affects the redistribution of Lck to the immunological synapse in primary T cells : implications for T-cell activation during human_immunodeficiency_virus_type_1_infection .
20837541	0	Lck	63,66	CD4	0,3	Lck	CD4	3932	920	Gene	Gene	delivery|compound|START_ENTITY enhance|dobj|delivery acts|xcomp|enhance acts|nsubj|END_ENTITY	CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery .
22529380	0	Lck	28,31	CD4	39,42	Lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|maturation maturation|compound|END_ENTITY	Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold .
8887682	0	Lck	77,80	CD4	50,53	Lck	CD4	3932	920	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|Binding Binding|nmod|END_ENTITY	Binding of human_immunodeficiency_virus_type_1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway .
20417561	0	Lck	29,32	CD44	0,4	Lck	CD44	3932	960	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD44 interacts directly with Lck in a zinc-dependent manner .
9573028	0	Lck	76,79	CD44	0,4	Lck	CD44	3932	960	Gene	Gene	kinases|dobj|START_ENTITY kinases|nsubj|associates associates|nummod|END_ENTITY	CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes .
10636863	1	Lck	133,136	Cd38	72,76	Lck	Cd38	3932	952	Gene	Gene	transduces|nmod|START_ENTITY transduces|nsubj|END_ENTITY	Cd38 transduces T cell activation signals through associated Lck .
12560083	0	Lck	25,28	Ezrin	0,5	Lck	Ezrin	3932	7430	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Ezrin is a substrate for Lck in T cells .
12732664	0	Lck	53,56	Fyn	14,17	Lck	Fyn	3932	2534	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Fyn through translocation of activated Lck into lipid rafts .
18660530	0	Lck	86,89	Fyn	14,17	Lck	Fyn	16818(Tax:10090)	14360(Tax:10090)	Gene	Gene	targeting|nmod|START_ENTITY requires|xcomp|targeting requires|nsubj|activation activation|compound|END_ENTITY	Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts .
8934569	0	Lck	33,36	Fyn	0,3	Lck	Fyn	16818(Tax:10090)	14360(Tax:10090)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	Fyn can partially substitute for Lck in T lymphocyte development .
15199125	0	Lck	36,39	Hsp90	43,48	Lck	Hsp90	3932	3320	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Regulation of the Src family kinase Lck by Hsp90 and ubiquitination .
21061443	0	Lck	0,3	IL-10	14,19	Lck	IL-10	16818(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Lck regulates IL-10 expression in memory-like Th1 cells .
20881207	0	Lck	48,51	INF2	7,11	Lck	INF2	3932	64423	Gene	Gene	transport|nmod|START_ENTITY regulates|dobj|transport regulates|nsubj|END_ENTITY	Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes .
18653462	0	Lck	17,20	L-selectin	24,34	Lck	L-selectin	16818(Tax:10090)	20343(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Critical role of Lck in L-selectin signaling induced by sulfatides engagement .
10544125	0	Lck	96,99	Nef	58,61	Lck	Nef	3932	156110(Tax:11676)	Gene	Gene	association|nmod|START_ENTITY essential|nmod|association essential|nsubj|core core|nmod|END_ENTITY	The conserved core of human_immunodeficiency_virus_type_1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes .
15976924	0	Lck	59,62	Nef	46,49	Lck	Nef	3932	156110(Tax:11676)	Gene	Gene	SH3|compound|START_ENTITY Mapping|nmod|SH3 Mapping|dobj|site site|nmod|END_ENTITY	Mapping the binding site of full length HIV-1 Nef on human Lck SH3 by NMR spectroscopy .
18030346	0	Lck	54,57	Nef	6,9	Lck	Nef	3932	6285	Gene	Gene	localization|compound|START_ENTITY employs|nmod|localization employs|nsubj|END_ENTITY	HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling .
19050260	0	Lck	47,50	Nef	34,37	Lck	Nef	3932	6285	Gene	Gene	activation|compound|START_ENTITY involves|dobj|activation involves|nsubj|Induction Induction|nmod|transcription transcription|nmod|END_ENTITY	Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B .
8626429	0	Lck	48,51	Nef	39,42	Lck	Nef	3932	6285	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of Nef with Lck .
8794306	0	Lck	58,61	Nef	36,39	Lck	Nef	3932	6285	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef binds directly to Lck and mitogen-activated protein kinase , inhibiting kinase activity .
9075929	0	Lck	82,85	Nef	18,21	Lck	Nef	3932	156110(Tax:11676)	Gene	Gene	containing|dobj|START_ENTITY complex|acl|containing associates|nmod|complex associates|dep|N-terminus N-terminus|nmod|END_ENTITY	The N-terminus of Nef from HIV-1 / SIV associates with a protein complex containing Lck and a serine kinase .
9705913	0	Lck	90,93	Nef	40,43	Lck	Nef	3932	156110(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY binds|dobj|domain binds|nsubj|protein protein|compound|END_ENTITY	The human_immunodeficiency_virus_type_1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism .
19192391	0	Lck	20,23	PKD2	0,4	Lck	PKD2	3932	25865	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PKD2 interacts with Lck and regulates NFAT activity in T cells .
8939988	0	Lck	75,78	Raf-1	21,26	Lck	Raf-1	3932	5894	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck .
12837766	0	Lck	98,101	SAP-1	15,20	Lck	SAP-1	3932	5794	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of SAP-1 , a transmembrane-type protein-tyrosine phosphatase , with the tyrosine kinase Lck .
17078813	0	Lck	117,120	STAT3	18,23	Lck	STAT3	3932	6774	Gene	Gene	requires|dobj|START_ENTITY END_ENTITY|acl:relcl|requires	Cr -LRB- VI -RRB- - stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck .
10975797	0	Lck	73,76	T_cell-specific_adapter_protein	0,31	Lck	T cell-specific adapter protein	3932	9047	Gene	Gene	activity|compound|START_ENTITY modulating|dobj|activity inhibits|advcl|modulating inhibits|nsubj|END_ENTITY	T_cell-specific_adapter_protein inhibits T cell activation by modulating Lck activity .
15827961	0	Lck	102,105	T_cell-specific_adapter_protein	18,49	Lck	T cell-specific adapter protein	3932	9047	Gene	Gene	activity|compound|START_ENTITY inhibition|nmod|activity necessary|nmod|inhibition necessary|nsubj|terminus terminus|nmod|END_ENTITY	The C terminus of T_cell-specific_adapter_protein -LRB- TSAd -RRB- is necessary for TSAd-mediated inhibition of Lck activity .
18541536	0	Lck	14,17	T_cell-specific_adapter_protein	56,87	Lck	T cell-specific adapter protein	3932	9047	Gene	Gene	Modulation|nmod|START_ENTITY function|nsubj|Modulation function|nmod|multisite multisite|acl|docking docking|nmod|END_ENTITY	Modulation of Lck function through multisite docking to T_cell-specific_adapter_protein .
21061443	0	Lck	0,3	Th1	46,49	Lck	Th1	16818(Tax:10090)	57314(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Lck regulates IL-10 expression in memory-like Th1 cells .
10903801	0	Lck	0,3	interleukin-2	19,32	Lck	interleukin-2	3932	3558	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Lck is involved in interleukin-2 induced proliferation but not cell survival in human T cells through a MAP kinase-independent pathway .
26628998	0	Lck	74,77	lymphocyte-specific_protein_tyrosine_kinase	29,72	Lck	lymphocyte-specific protein tyrosine kinase	16818(Tax:10090)	16818(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of siRNA-mediated lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- inhibition on pulmonary_inflammation in a mouse model of asthma .
10330160	0	Lck	22,25	p56	18,21	Lck	p56	16818(Tax:10090)	15957(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Expression of the p56 -LRB- Lck -RRB- Y505F mutation in CD45-deficient mice rescues thymocyte development .
19046675	0	Lck	105,108	p56	101,104	Lck	p56	3932	8999	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Validated quantitative structure-activity relationship analysis of a series of 2-aminothiazole based p56 -LRB- Lck -RRB- inhibitors .
24382649	0	Lcn2	13,17	Lipocalin-2	0,11	Lcn2	Lipocalin-2	170496(Tax:10116)	170496(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lipocalin-2 -LRB- Lcn2 -RRB- expression is mediated by maternal nutrition during the development of the fetal liver .
22609543	0	Ldb1	0,4	carbonic_anhydrase_1	15,35	Ldb1	carbonic anhydrase 1	8861	759	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Ldb1 regulates carbonic_anhydrase_1 during erythroid differentiation .
18930904	0	Ldhc	38,42	lactate_dehydrogenase_c	13,36	Ldhc	lactate dehydrogenase c	3948	3948	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Homo_sapiens lactate_dehydrogenase_c -LRB- Ldhc -RRB- gene expression in cancer cells is regulated by transcription factor Sp1 , CREB , and CpG island methylation .
23431047	0	Ldlr	95,99	farnesoid_X_receptor	71,91	Ldlr	farnesoid X receptor	16835(Tax:10090)	20186(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of bile_acid and cholesterol metabolism by the farnesoid_X_receptor in Ldlr - / - mice versus hamsters .
14976239	0	LeMAN5	43,49	endo-beta-mannanase	8,27	LeMAN5	endo-beta-mannanase	544170(Tax:4081)	543823(Tax:4081)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	A novel endo-beta-mannanase gene in tomato LeMAN5 is associated with anther and pollen development .
15255864	0	LePRK1	74,80	LeSTIG1	0,7	LePRK1	LeSTIG1	544021(Tax:4081)	543904(Tax:4081)	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	LeSTIG1 , an extracellular binding partner for the pollen receptor kinases LePRK1 and LePRK2 , promotes pollen tube growth in vitro .
15255864	0	LeSTIG1	0,7	LePRK1	74,80	LeSTIG1	LePRK1	543904(Tax:4081)	544021(Tax:4081)	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	LeSTIG1 , an extracellular binding partner for the pollen receptor kinases LePRK1 and LePRK2 , promotes pollen tube growth in vitro .
278893	0	Lecithin-cholesterol_acyltransferase	0,36	LCAT	38,42	Lecithin-cholesterol acyltransferase	LCAT	3931	3931	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Lecithin-cholesterol_acyltransferase -LRB- LCAT -RRB- activity in chronic_uremia .
19682715	0	Lecithin_cholesterol_acyltransferase	0,36	LCAT	38,42	Lecithin cholesterol acyltransferase	LCAT	3931	3931	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Lecithin_cholesterol_acyltransferase -LRB- LCAT -RRB- activity as a predictor for ketosis and parturient haemoglobinuria in Egyptian water buffaloes .
24383078	0	Lecithin_cholesterol_acyltransferase	0,36	LCAT	38,42	Lecithin cholesterol acyltransferase	LCAT	3931	3931	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Lecithin_cholesterol_acyltransferase -LRB- LCAT -RRB- activity in the presence of Apo-AI-derived peptides exposed to disorder-order conformational transitions .
24513206	0	Lecithin_cholesterol_acyltransferase	0,36	LCAT	38,42	Lecithin cholesterol acyltransferase	LCAT	3931	3931	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Lecithin_cholesterol_acyltransferase -LRB- LCAT -RRB- activity in the presence of Apo-AI-derived peptides exposed to disorder-order conformational transitions .
24902807	0	Lectin-Like_ox-LDL_Receptor-1	0,29	Toll-Like_Receptor_4	38,58	Lectin-Like ox-LDL Receptor-1	Toll-Like Receptor 4	108078(Tax:10090)	21898(Tax:10090)	Gene	Gene	START_ENTITY|dep|Interaction Interaction|compound|END_ENTITY	Lectin-Like_ox-LDL_Receptor-1 -LRB- LOX-1 -RRB- - Toll-Like_Receptor_4 -LRB- TLR4 -RRB- Interaction and Autophagy in CATH.a Differentiated Cells Exposed to Angiotensin_II .
19218767	0	Lectin-like_oxidized_LDL_receptor-1	0,35	LOX-1	37,42	Lectin-like oxidized LDL receptor-1	LOX-1	4973	4973	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in the tubulointerstitial area likely plays an important role in human diabetic_nephropathy .
16173915	0	Lectin-like_oxidized_low-density_lipoprotein_receptor-1	0,55	Oct-1	94,99	Lectin-like oxidized low-density lipoprotein receptor-1	Oct-1	4973	5451	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	Lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- transcriptional regulation by Oct-1 in human endothelial cells : implications for atherosclerosis .
17888218	0	Lectin-like_oxidized_low_density_lipoprotein_receptor_1	0,55	LOX-1	57,62	Lectin-like oxidized low density lipoprotein receptor 1	LOX-1	4973	4973	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lectin-like_oxidized_low_density_lipoprotein_receptor_1 -LRB- LOX-1 -RRB- expression in human articular chondrocytes .
17335794	0	Lef-1	16,21	Wnt3a	0,5	Lef-1	Wnt3a	16842(Tax:10090)	22416(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis .
11854293	0	Lef-1	129,134	beta-catenin	135,147	Lef-1	beta-catenin	16842(Tax:10090)	12387(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY perturbed|nmod|stimulation END_ENTITY|dep|perturbed	Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1 / beta-catenin signaling .
17945188	0	Lef1	0,4	COX-2	15,20	Lef1	COX-2	16842(Tax:10090)	17709(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Lef1 regulates COX-2 transcription in chondrocytes .
23637337	0	Lef1	0,4	Dusp6	15,20	Lef1	Dusp6	30701(Tax:7955)	353314(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium .
17971297	0	Lef1	39,43	MMP13	30,35	Lef1	MMP13	16842(Tax:10090)	17386(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of MMP13 by Lef1 in chondrocytes .
17445771	0	Lef1	20,24	NF-kappaB	0,9	Lef1	NF-kappaB	51176	4790	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappaB regulates Lef1 gene expression in chondrocytes .
20736303	0	Leiomodin-2	0,11	tropomodulin-1	32,46	Leiomodin-2	tropomodulin-1	442721	7111	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle .
26012374	0	Lep	117,120	Lep	126,129	Lep	Lep	16846(Tax:10090)	16846(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Beneficial Effects of Supplementation of the Rare Sugar `` D-allulose '' Against Hepatic_Steatosis and Severe_Obesity in Lep -LRB- ob -RRB- / Lep -LRB- ob -RRB- Mice .
26012374	0	Lep	126,129	Lep	117,120	Lep	Lep	16846(Tax:10090)	16846(Tax:10090)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Beneficial Effects of Supplementation of the Rare Sugar `` D-allulose '' Against Hepatic_Steatosis and Severe_Obesity in Lep -LRB- ob -RRB- / Lep -LRB- ob -RRB- Mice .
10426312	0	Lep	24,27	leptin	14,20	Lep	leptin	3952	3952	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	The effect of leptin on Lep expression is tissue-specific and nutritionally regulated .
27101301	0	LepR	48,52	GnRH-R	56,62	LepR	GnRH-R	16847(Tax:10090)	14715(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Leptin_receptor null mice with re-expression of LepR in GnRH-R expressing cells display elevated FSH levels but remain in a prepubertal state .
12612136	0	Lepr	138,142	Lepr	147,151	Lepr	Lepr	16847(Tax:10090)	16847(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Altering dietary protein type and quantity reduces urinary albumin excretion without affecting plasma glucose concentrations in BKS.cg-m + Lepr db / + Lepr db -LRB- db/db -RRB- mice .
12612136	0	Lepr	147,151	Lepr	138,142	Lepr	Lepr	16847(Tax:10090)	16847(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Altering dietary protein type and quantity reduces urinary albumin excretion without affecting plasma glucose concentrations in BKS.cg-m + Lepr db / + Lepr db -LRB- db/db -RRB- mice .
12730408	0	Lepr	39,43	leptin_receptor	4,19	Lepr	leptin receptor	16847(Tax:10090)	16847(Tax:10090)	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	New leptin_receptor mutations in mice : Lepr -LRB- db-rtnd -RRB- , Lepr -LRB- db-dmpg -RRB- and Lepr -LRB- db-rlpy -RRB- .
20614101	0	Leptin	0,6	ACE	17,20	Leptin	ACE	16846(Tax:10090)	11421(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Leptin regulates ACE activity in mice .
12734209	0	Leptin	0,6	AP-1	21,25	Leptin	AP-1	3952	2354	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Leptin enhances , via AP-1 , expression of aromatase in the MCF-7 cell line .
25499980	0	Leptin	0,6	ATPase	31,37	Leptin	ATPase	3952	1769	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Leptin inhibits the Na -LRB- + -RRB- / K -LRB- + -RRB- ATPase in Caco-2 cells via PKC and p38MAPK .
25793395	0	Leptin	15,21	Adiponectin	49,60	Leptin	Adiponectin	3952	9370	Gene	Gene	START_ENTITY|nmod|Ratio Ratio|compound|END_ENTITY	Elevated Serum Leptin , Adiponectin and Leptin to Adiponectin Ratio Is Associated with Chronic_Kidney_Disease in Asian Adults .
26078399	0	Leptin	7,13	Adiponectin	15,26	Leptin	Adiponectin	3952	9370	Gene	Gene	START_ENTITY|appos|Levels Levels|compound|END_ENTITY	Plasma Leptin , Adiponectin , Neuropeptide_Y Levels in Drug Naive Children With ADHD .
12411472	0	Leptin	0,6	Akt	50,53	Leptin	Akt	3952	207	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Leptin induces endothelial cell migration through Akt , which is inhibited by PPARgamma-ligands .
17660512	0	Leptin	0,6	Akt	57,60	Leptin	Akt	16846(Tax:10090)	11651(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Leptin induces CD40 expression through the activation of Akt in murine dendritic cells .
25989537	0	Leptin	0,6	Akt	140,143	Leptin	Akt	3952	207	Gene	Gene	START_ENTITY|parataxis|Pathway Pathway|compound|END_ENTITY	Leptin and Neutrophil-Activating_Peptide_2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol_3-Kinase / Akt Pathway in Patients With Systemic Lupus Erythematosus .
26655697	0	Leptin	41,47	Amylin	13,19	Leptin	Amylin	16846(Tax:10090)	15874(Tax:10090)	Gene	Gene	Concert|nmod|START_ENTITY Acts|nmod|Concert Acts|nsubj|END_ENTITY	Hypothalamic Amylin Acts in Concert with Leptin to Regulate Food Intake .
26933237	0	Leptin	42,48	C-Reactive_Protein	6,24	Leptin	C-Reactive Protein	3952	1401	Gene	Gene	Entry|nmod|START_ENTITY Impedes|dobj|Entry Impedes|nsubj|END_ENTITY	Human C-Reactive_Protein Impedes Entry of Leptin into the CNS and Attenuates Its Physiological Actions in the CNS .
26005385	0	Leptin	15,21	C-reactive_Protein	82,100	Leptin	C-reactive Protein	3952	1401	Gene	Gene	Level|compound|START_ENTITY Associated|nsubj|Level Associated|dep|Not Not|nmod|END_ENTITY	Elevated Serum Leptin Level Is Associated with Body Mass Index But Not with Serum C-reactive_Protein and Erythrocyte Sedimentation Rate Values in Hemodialysis Patients .
16764962	0	Leptin	0,6	C-reactive_protein	75,93	Leptin	C-reactive protein	3952	1401	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Leptin , triglycerides , and interleukin_6 are independently associated with C-reactive_protein in Japanese type 2 diabetic patients .
17615382	0	Leptin	0,6	C-reactive_protein	15,33	Leptin	C-reactive protein	3952	1401	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Leptin induces C-reactive_protein expression in vascular endothelial cells .
19571581	0	Leptin	0,6	C-reactive_protein	18,36	Leptin	C-reactive protein	3952	1401	Gene	Gene	stimulated|nsubj|START_ENTITY stimulated|dobj|production production|amod|END_ENTITY	Leptin stimulated C-reactive_protein production by human coronary artery endothelial cells .
25303952	0	Leptin	0,6	CD16	17,21	Leptin	CD16	3952	2214	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Leptin regulates CD16 expression on human monocytes in a sex-specific manner .
17660512	0	Leptin	0,6	CD40	15,19	Leptin	CD40	16846(Tax:10090)	21939(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Leptin induces CD40 expression through the activation of Akt in murine dendritic cells .
24351431	0	Leptin	0,6	COXIV	22,27	Leptin	COXIV	3952	1327	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Leptin stimulation of COXIV is impaired_in_obese_skeletal_muscle_myotubes .
24631339	0	Leptin	0,6	CYP1B1	15,21	Leptin	CYP1B1	3952	1545	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Leptin induces CYP1B1 expression in MCF-7 cells through ligand-independent activation of the ERa pathway .
25583546	0	Leptin	0,6	Dentin_Sialophosphoprotein	16,42	Leptin	Dentin Sialophosphoprotein	3952	1834	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Leptin Promotes Dentin_Sialophosphoprotein Expression in Human Dental Pulp .
10619403	0	Leptin	0,6	ERK2	72,76	Leptin	ERK2	16846(Tax:10090)	26413(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2 .
10853188	0	Leptin	0,6	GH	41,43	Leptin	GH	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Leptin stimulates basal and GHRH-induced GH release from cultured rat anterior pituitary cells in vitro .
9724042	0	Leptin	0,6	GH	71,73	Leptin	GH	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulator|nsubj|START_ENTITY stimulator|nmod|secretion secretion|appos|END_ENTITY	Leptin is a potent stimulator of spontaneous pulsatile growth_hormone -LRB- GH -RRB- secretion and the GH response to GH-releasing_hormone .
10633224	0	Leptin	0,6	GHRH	41,45	Leptin	GHRH	25608(Tax:10116)	29446(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Leptin increases in vivo GH responses to GHRH and GH-releasing_peptide-6 in food-deprived rats .
18262553	0	Leptin	0,6	HER2	76,80	Leptin	HER2	3952	2064	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|proliferation proliferation|nmod|cells cells|nmod|transactivation transactivation|nmod|END_ENTITY	Leptin augments proliferation of breast_cancer cells via transactivation of HER2 .
23228483	0	Leptin	0,6	HER2	17,21	Leptin	HER2	3952	2064	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nummod|END_ENTITY	Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast_cancer cells .
25649687	0	Leptin	0,6	HLA-G	16,21	Leptin	HLA-G	3952	3135	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways .
26276826	0	Leptin	0,6	ICAM-1	16,22	Leptin	ICAM-1	3952	3383	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Leptin Enhances ICAM-1 Expression , Induces Migration and Cytokine Synthesis , and Prolongs Survival of Human Airway Epithelial Cells .
10670656	0	Leptin	0,6	IGF-1	133,138	Leptin	IGF-1	396832(Tax:9823)	101055342	Gene	Gene	expression|compound|START_ENTITY reduced|nsubjpass|expression reduced|nmod|endotoxemia endotoxemia|dep|correlation correlation|nmod|glucose glucose|appos|END_ENTITY	Leptin expression is reduced with acute endotoxemia in the pig : correlation with glucose , insulin , and insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- .
11081190	0	Leptin	0,6	IGF-I	13,18	Leptin	IGF-I	3952	3479	Gene	Gene	START_ENTITY|nmod|generation generation|amod|END_ENTITY	Leptin after IGF-I generation test in a patient with hypopituitarism and myotonic_dystrophy_disease .
15141093	0	Leptin	0,6	IL-1_receptor_antagonist	41,65	Leptin	IL-1 receptor antagonist	3952	3557	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Leptin modulates beta cell expression of IL-1_receptor_antagonist and release of IL-1beta in human islets .
15141093	0	Leptin	0,6	IL-1beta	81,89	Leptin	IL-1beta	3952	3553	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Leptin modulates beta cell expression of IL-1_receptor_antagonist and release of IL-1beta in human islets .
17565544	0	Leptin	0,6	IL-6	51,55	Leptin	IL-6	3952	3569	Gene	Gene	markers|amod|START_ENTITY markers|appos|TNF-alpha TNF-alpha|dep|END_ENTITY	Leptin , IL-10 and inflammatory markers -LRB- TNF-alpha , IL-6 and IL-8 -RRB- in pre-eclamptic , normotensive pregnant and healthy non-pregnant women .
24086566	0	Leptin	0,6	IL-6	15,19	Leptin	IL-6	3952	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Leptin induces IL-6 expression through OBRl receptor signaling pathway in human synovial fibroblasts .
9728091	0	Leptin	0,6	IL-6	96,100	Leptin	IL-6	16846(Tax:10090)	16193(Tax:10090)	Gene	Gene	causes|nsubj|START_ENTITY causes|xcomp|typical typical|nmod|cytokines cytokines|nmod|family family|compound|END_ENTITY	Leptin causes body weight_loss in the absence of in vivo activities typical of cytokines of the IL-6 family .
18501560	0	Leptin	0,6	IL-8	15,19	Leptin	IL-8	3952	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Leptin induces IL-8 expression via leptin receptor , IRS-1 , PI3K , Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts .
25821463	0	Leptin	21,27	Insulin	95,102	Leptin	Insulin	3952	3630	Gene	Gene	Variations|compound|START_ENTITY Variations|nmod|Resistance Resistance|compound|END_ENTITY	HOMA , BMI , and Serum Leptin Levels Variations during Antiviral Treatment Suggest Virus-Related Insulin Resistance in Noncirrhotic , Nonobese , and Nondiabetic_Chronic_Hepatitis_C Genotype 1 Patients .
19112600	0	Leptin	0,6	Jun_N-terminal_kinases	16,38	Leptin	Jun N-terminal kinases	3952	5599	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|END_ENTITY	Leptin utilizes Jun_N-terminal_kinases to stimulate the invasion of MCF-7_breast_cancer cells .
24910643	0	Leptin	14,20	KiSS-1	40,46	Leptin	KiSS-1	25608(Tax:10116)	289023(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of Leptin and Adiponectin on KiSS-1 and KissR mRNA Expression in Rat Islets of Langerhans and CRI-D2 Cell Line .
26180527	0	Leptin	0,6	Leptin	23,29	Leptin	Leptin	3952	3952	Gene	Gene	Receptor|amod|START_ENTITY Receptor|compound|END_ENTITY	Leptin as well as Free Leptin Receptor Is Associated with Polycystic_Ovary_Syndrome in Young Women .
26180527	0	Leptin	23,29	Leptin	0,6	Leptin	Leptin	3952	3952	Gene	Gene	Receptor|compound|START_ENTITY Receptor|amod|END_ENTITY	Leptin as well as Free Leptin Receptor Is Associated with Polycystic_Ovary_Syndrome in Young Women .
21345293	0	Leptin	0,6	MMP-1	16,21	Leptin	MMP-1	3952	4312	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Leptin enhances MMP-1 , MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients .
22065732	0	Leptin	0,6	MMP9	116,120	Leptin	MMP9	16846(Tax:10090)	17395(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9 .
20497020	0	Leptin	0,6	MUC5B	20,25	Leptin	MUC5B	3952	727897	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway .
26078399	0	Leptin	7,13	Neuropeptide_Y	28,42	Leptin	Neuropeptide Y	3952	4852	Gene	Gene	START_ENTITY|appos|Levels Levels|appos|END_ENTITY	Plasma Leptin , Adiponectin , Neuropeptide_Y Levels in Drug Naive Children With ADHD .
26538454	0	Leptin	207,213	Neuropeptide_Y	87,101	Leptin	Neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY Changes|nmod|Signaling Independently|nmod|Changes Associated|nmod|Independently Associated|nmod|Expression Expression|nmod|END_ENTITY	Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide_Y and Proopiomelanocortin in the Arcuate Nucleus , Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling .
26824363	0	Leptin	10,16	PCSK9	32,37	Leptin	PCSK9	16846(Tax:10090)	100102(Tax:10090)	Gene	Gene	Replacement|compound|START_ENTITY Replacement|nmod|END_ENTITY	Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients .
26218179	0	Leptin	0,6	PGC1a	52,57	Leptin	PGC1a	3952	10891	Gene	Gene	Effect|compound|START_ENTITY Effect|nmod|END_ENTITY	Leptin Effect on Acetylation and Phosphorylation of PGC1a in Muscle Cells Associated With AMPK and Akt Activation in High-Glucose Medium .
15581426	0	Leptin	0,6	PI3K	83,87	Leptin	PI3K	16846(Tax:10090)	18708(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|dep|reorganization reorganization|nummod|END_ENTITY	Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones : PI3K dependent actin reorganization and KATP channel activation .
16335797	0	Leptin	0,6	PPAR-gamma	72,82	Leptin	PPAR-gamma	3952	5468	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Leptin down-regulates peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- mRNA levels in primary human monocyte-derived macrophages .
20226837	0	Leptin	0,6	PPARgamma	16,25	Leptin	PPARgamma	16846(Tax:10090)	19016(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver_damage .
24032047	0	Leptin	15,21	Pdx1	41,45	Leptin	Pdx1	25608(Tax:10116)	29535(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Leptin and Adiponectin on Pdx1 , Foxm1 , and PPARy Transcription in Rat Islets of Langerhans .
16479591	0	Leptin	0,6	RANKL	17,22	Leptin	RANKL	16846(Tax:10090)	21943(Tax:10090)	Gene	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts .
12556536	0	Leptin	0,6	STAT3	82,87	Leptin	STAT3	3952	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Leptin activates the anandamide hydrolase promoter in human T lymphocytes through STAT3 .
17095713	0	Leptin	0,6	STAT3	132,137	Leptin	STAT3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|dep|leptin_receptor leptin_receptor|parataxis|signaling signaling|nsubj|END_ENTITY	Leptin regulates neointima formation after arterial_injury through mechanisms independent of blood pressure and the leptin_receptor / STAT3 signaling pathways involved in energy balance .
19203792	0	Leptin	0,6	STAT3	90,95	Leptin	STAT3	3952	6774	Gene	Gene	affects|nsubj|START_ENTITY affects|nmod|mechanisms mechanisms|nummod|END_ENTITY	Leptin affects system A amino_acid transport activity in the human placenta : evidence for STAT3 dependent mechanisms .
21671179	0	Leptin	0,6	STAT3	17,22	Leptin	STAT3	3952	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|ccomp|pathways pathways|nsubj|END_ENTITY	Leptin activates STAT3 and ERK1/2 pathways and induces endometrial_cancer_cell_proliferation .
23216800	0	Leptin	0,6	STAT3	31,36	Leptin	STAT3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|activation activation|compound|END_ENTITY	Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells .
25550283	0	Leptin	0,6	STAT3	55,60	Leptin	STAT3	25608(Tax:10116)	25125(Tax:10116)	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus .
26341832	0	Leptin	0,6	STAT3	55,60	Leptin	STAT3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|Effects Effects|acl|Running Running|nmod|Signaling Signaling|compound|END_ENTITY	Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons .
26403688	0	Leptin	0,6	STAT3	65,70	Leptin	STAT3	373955(Tax:9031)	420027(Tax:9031)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Leptin activates chicken growth_hormone promoter without chicken STAT3 in vitro .
26936086	0	Leptin	0,6	STAT3	100,105	Leptin	STAT3	3952	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|dep|END_ENTITY	Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2 - STAT3 signaling pathway .
22133921	0	Leptin	0,6	Signal_Transducers_and_Activators_of_Transcription_3	61,113	Leptin	Signal Transducers and Activators of Transcription 3	3952	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Leptin promotes human glioblastoma growth through activating Signal_Transducers_and_Activators_of_Transcription_3 signaling .
11064148	0	Leptin	0,6	Stat3	17,22	Leptin	Stat3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Leptin activates Stat3 , Stat1 and AP-1 in mouse adipose tissue .
24486192	0	Leptin	0,6	Stat3	133,138	Leptin	Stat3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling regulates|dobj|expression expression|nmod|Nhlh2 Nhlh2|nmod|signal_transducer_and_activator_3 signal_transducer_and_activator_3|appos|END_ENTITY	Leptin signaling regulates hypothalamic expression of nescient_helix-loop-helix_2 -LRB- Nhlh2 -RRB- through signal_transducer_and_activator_3 -LRB- Stat3 -RRB- .
8782827	0	Leptin	0,6	Stat3	21,26	Leptin	Stat3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice .
14552388	0	Leptin	0,6	TNF	37,40	Leptin	TNF	443534(Tax:9940)	443540(Tax:9940)	Gene	Gene	START_ENTITY|appos|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|appos|END_ENTITY	Leptin , tumor_necrosis_factor-alpha -LRB- TNF -RRB- , and CD14 in ovine adipose tissue and changes in circulating TNF in lean and fat sheep .
25047119	0	Leptin	0,6	TNF-a	17,22	Leptin	TNF-a	16846(Tax:10090)	21926(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Leptin increases TNF-a expression and production through phospholipase_D1 in Raw 264.7 cells .
15979653	0	Leptin	0,6	TNF-alpha	16,25	Leptin	TNF-alpha	25608(Tax:10116)	24835(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells .
25230157	0	Leptin	0,6	VEGF	17,21	Leptin	VEGF	3952	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Leptin increases VEGF expression and enhances angiogenesis in human chondrosarcoma cells .
15126241	0	Leptin	0,6	adiponectin	43,54	Leptin	adiponectin	16846(Tax:10090)	11450(Tax:10090)	Gene	Gene	markedly|compound|START_ENTITY increased|nsubj|markedly increased|dobj|END_ENTITY	Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice .
17823381	0	Leptin	0,6	adiponectin	7,18	Leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|parataxis|predictor predictor|nsubj|ratio ratio|compound|END_ENTITY	Leptin : adiponectin ratio is an independent predictor of intima_media_thickness of the common carotid artery .
19441676	0	Leptin	1,7	adiponectin	11,22	Leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	-LSB- Leptin to adiponectin ratio , as an index of insulin resistance and atherosclerosis development -RSB- .
19855365	0	Leptin	0,6	adiponectin	31,42	Leptin	adiponectin	3952	9370	Gene	Gene	leptin|nsubj|START_ENTITY leptin|xcomp|END_ENTITY	Leptin , adiponectin , leptin to adiponectin ratio and insulin resistance in depressive women .
21779189	0	Leptin	0,6	adiponectin	7,18	Leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Leptin : adiponectin ratio and metabolic_syndrome in the general Japanese population .
21951069	0	Leptin	0,6	adiponectin	8,19	Leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|appos|adipokines_in_gestational_diabetes_mellitus adipokines_in_gestational_diabetes_mellitus|compound|END_ENTITY	Leptin , adiponectin and other adipokines_in_gestational_diabetes_mellitus and pre-eclampsia .
23066861	0	Leptin	0,6	adiponectin	10,21	Leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Leptin to adiponectin ratio as a useful predictor for cardiac_syndrome_X .
23923407	0	Leptin	0,6	adiponectin	10,21	Leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Leptin to adiponectin ratio in preeclampsia .
25622736	0	Leptin	1,7	adiponectin	9,20	Leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|appos|hormone hormone|compound|END_ENTITY	-LSB- Leptin , adiponectin and sex hormone in benign_acanthosis_nigricans of males -RSB- .
11152449	0	Leptin	0,6	angiopoietin-2	15,29	Leptin	angiopoietin-2	25608(Tax:10116)	89805(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Leptin induces angiopoietin-2 expression in adipose tissues .
16144973	0	Leptin	0,6	angiotensin_II	63,77	Leptin	angiotensin II	25608(Tax:10116)	24179(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Leptin induces vascular smooth muscle cell hypertrophy through angiotensin_II - and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy .
20592755	0	Leptin	0,6	angiotensin_II	77,91	Leptin	angiotensin II	25608(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|cells cells|acl|induced induced|nmod|END_ENTITY	Leptin inhibits the proliferation of vascular smooth muscle cells induced by angiotensin_II through nitric_oxide-dependent mechanisms .
18556347	0	Leptin	0,6	beta-defensin-2	22,37	Leptin	beta-defensin-2	3952	1673	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Leptin enhances human beta-defensin-2 production in human keratinocytes .
21074769	0	Leptin	0,6	caveolin-1	19,29	Leptin	caveolin-1	3952	857	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Leptin upregulates caveolin-1 expression : implications for development of atherosclerosis .
10422768	0	Leptin	0,6	cholecystokinin	38,53	Leptin	cholecystokinin	25608(Tax:10116)	25298(Tax:10116)	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Leptin in gastroprotection induced by cholecystokinin or by a meal .
15734493	0	Leptin	0,6	cholecystokinin	46,61	Leptin	cholecystokinin	16846(Tax:10090)	12424(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|response response|acl|END_ENTITY	Leptin increases small intestinal response to cholecystokinin in leptin-deficient_obese_mice .
22412960	0	Leptin	0,6	cholecystokinin	53,68	Leptin	cholecystokinin	25608(Tax:10116)	25298(Tax:10116)	Gene	Gene	resistance|compound|START_ENTITY inhibits|nsubj|resistance inhibits|dobj|signaling signaling|amod|END_ENTITY	Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats .
17639064	0	Leptin	0,6	cyclin_D1	96,105	Leptin	cyclin D1	3952	595	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|END_ENTITY	Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin_D1 and down-regulating Bax via a Janus_kinase_2-linked pathway .
21472344	0	Leptin	0,6	cyclin_D1	31,40	Leptin	cyclin D1	3952	595	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Leptin and zeranol up-regulate cyclin_D1 expression in primary cultured normal human breast pre-adipocytes .
22692856	0	Leptin	0,6	cyclin_D1	17,26	Leptin	cyclin D1	16846(Tax:10090)	12443(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Leptin regulates cyclin_D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary_tumors .
23300886	0	Leptin	0,6	cyclin_D1	15,24	Leptin	cyclin D1	3952	595	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Leptin induces cyclin_D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT , PI3K/Akt and MEK/ERK pathways .
23354006	0	Leptin	0,6	cyclin_D1	82,91	Leptin	cyclin D1	3952	595	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|increasing increasing|dobj|expression expression|amod|END_ENTITY	Leptin stimulates ovarian_cancer cell growth and inhibits apoptosis by increasing cyclin_D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways .
17074047	0	Leptin	0,6	cyclooxygenase-2	15,31	Leptin	cyclooxygenase-2	25608(Tax:10116)	29527(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain .
19154413	0	Leptin	0,6	cyclooxygenase-2	40,56	Leptin	cyclooxygenase-2	3952	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|pathways pathways|amod|END_ENTITY	Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3 , MAPK/ERK , and PI3K/AKT pathways in human endometrial_cancer cells .
11934840	0	Leptin	0,6	endothelin-1	15,27	Leptin	endothelin-1	3952	1906	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Leptin induces endothelin-1 in endothelial cells in vitro .
17678888	0	Leptin	0,6	endothelin-1	18,30	Leptin	endothelin-1	25608(Tax:10116)	24323(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal_growth_factor_receptor transactivation in rat aortic smooth muscle cells .
23372172	0	Leptin	0,6	endothelin-1	23,35	Leptin	endothelin-1	3952	1906	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Leptin stimulates both endothelin-1 and nitric_oxide activity in lean subjects but not in patients with obesity-related metabolic_syndrome .
24213635	0	Leptin	0,6	extracellular-signal_regulated_kinase	83,120	Leptin	extracellular-signal regulated kinase	3952	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|amod|END_ENTITY	Leptin promotes the proliferation and migration of human breast_cancer through the extracellular-signal_regulated_kinase pathway .
20200981	0	Leptin	0,6	fibroblast_growth_factor_23	18,45	Leptin	fibroblast growth factor 23	16846(Tax:10090)	64654(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Leptin stimulates fibroblast_growth_factor_23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin _ D3 synthesis in leptin-deficient mice .
10651760	0	Leptin	0,6	growth_hormone	64,78	Leptin	growth hormone	3952	2688	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|nsubj|concentrations	Leptin concentrations in Prader-Willi_syndrome before and after growth_hormone replacement .
12970164	0	Leptin	0,6	growth_hormone	15,29	Leptin	growth hormone	3952	2688	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Leptin induces growth_hormone secretion from peripheral blood mononuclear cells via a protein_kinase_C - and nitric_oxide-dependent mechanism .
15153755	0	Leptin	0,6	growth_hormone	18,32	Leptin	growth hormone	3952	2688	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Leptin stimulates growth_hormone secretion via a direct pituitary effect combined with a decreased somatostatin tone in a median eminence-pituitary perifusion study .
18445667	0	Leptin	0,6	growth_hormone	62,76	Leptin	growth hormone	3952	2688	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|pulsatility pulsatility|amod|END_ENTITY	Leptin does not mediate short-term fasting-induced changes in growth_hormone pulsatility but increases IGF-I in leptin_deficiency states .
26403688	0	Leptin	0,6	growth_hormone	25,39	Leptin	growth hormone	373955(Tax:9031)	378781(Tax:9031)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Leptin activates chicken growth_hormone promoter without chicken STAT3 in vitro .
9724042	0	Leptin	0,6	growth_hormone	55,69	Leptin	growth hormone	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulator|nsubj|START_ENTITY stimulator|nmod|secretion secretion|compound|END_ENTITY	Leptin is a potent stimulator of spontaneous pulsatile growth_hormone -LRB- GH -RRB- secretion and the GH response to GH-releasing_hormone .
17406896	0	Leptin	0,6	heat_shock_protein-70	21,42	Leptin	heat shock protein-70	373955(Tax:9031)	423504(Tax:9031)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Leptin downregulates heat_shock_protein-70 -LRB- HSP-70 -RRB- gene expression in chicken liver and hypothalamus .
10323373	0	Leptin	0,6	insulin	24,31	Leptin	insulin	3952	3630	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Leptin before and after insulin therapy in children with new-onset type 1 diabetes .
10523021	0	Leptin	0,6	insulin	19,26	Leptin	insulin	3952	3630	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Leptin response to insulin in humans is related to the lipolytic state of abdominal subcutaneous fat .
10690955	0	Leptin	0,6	insulin	80,87	Leptin	insulin	3952	3630	Gene	Gene	START_ENTITY|dep|relation relation|acl|serum serum|dobj|sensitivity sensitivity|compound|END_ENTITY	Leptin during and after preeclamptic or normal pregnancy : its relation to serum insulin and insulin sensitivity .
12369715	0	Leptin	0,6	insulin	67,74	Leptin	insulin	3952	3630	Gene	Gene	START_ENTITY|dep|effect effect|nmod|therapy therapy|compound|END_ENTITY	Leptin in children with newly diagnosed type 1 diabetes : effect of insulin therapy .
17441374	0	Leptin	1,7	insulin	74,81	Leptin	insulin	3952	3630	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|distribution distribution|nmod|tissue tissue|nmod|END_ENTITY	-LSB- Leptin correlates with distribution of fatty tissue and plasma levels of insulin , testosterone and tumor_necrosis_factor_alpha in perimenopausal women with increased testosterone level and central location of body fat -RSB- .
18370722	0	Leptin	0,6	insulin	26,33	Leptin	insulin	3952	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Leptin is associated with insulin resistance in Japanese migrants .
19115596	0	Leptin	1,7	insulin	9,16	Leptin	insulin	3952	3630	Gene	Gene	START_ENTITY|appos|mass mass|compound|END_ENTITY	-LSB- Leptin , insulin , IGF-1 and bone mass in a group of sedentary adolescent girls -RSB- .
19995720	0	Leptin	0,6	insulin	116,123	Leptin	insulin	3952	3630	Gene	Gene	concentrations|nsubj|START_ENTITY concentrations|advcl|index index|compound|END_ENTITY	Leptin concentrations in patients with polycystic_ovary_syndrome before and after met-formin treatment depending on insulin resistance , body mass index and androgen con-centrations -- introductory report .
22759970	0	Leptin	0,6	insulin	15,22	Leptin	insulin	16846(Tax:10090)	3630	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|action action|compound|END_ENTITY	Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity .
8801538	0	Leptin	0,6	insulin	61,68	Leptin	insulin	3952	3630	Gene	Gene	enters|nsubj|START_ENTITY enters|nmod|independent independent|nmod|END_ENTITY	Leptin enters the brain by a saturable system independent of insulin .
9024222	0	Leptin	0,6	insulin	50,57	Leptin	insulin	3952	3630	Gene	Gene	synthesis|compound|START_ENTITY resistant|nsubj|synthesis resistant|nmod|effects effects|nmod|END_ENTITY	Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes_mellitus patients .
9451467	0	Leptin	0,6	insulin	21,28	Leptin	insulin	3952	3630	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Leptin inhibition of insulin secretion from isolated human islets .
9725819	0	Leptin	0,6	insulin	84,91	Leptin	insulin	3952	3630	Gene	Gene	expression|compound|START_ENTITY expression|dep|regulation regulation|nmod|END_ENTITY	Leptin expression in adipose tissue from obese humans : depot-specific regulation by insulin and dexamethasone .
12213309	0	Leptin	0,6	interleukin-1beta	17,34	Leptin	interleukin-1beta	16846(Tax:10090)	16176(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms .
17074047	0	Leptin	0,6	interleukin-1beta	56,73	Leptin	interleukin-1beta	25608(Tax:10116)	24494(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|cyclooxygenase-2 cyclooxygenase-2|nmod|interaction interaction|nmod|END_ENTITY	Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain .
17419800	0	Leptin	0,6	interleukin-1beta	15,32	Leptin	interleukin-1beta	25608(Tax:10116)	24494(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Leptin induces interleukin-1beta release from rat microglial cells through a caspase_1 independent mechanism .
18535786	0	Leptin	0,6	interleukin-1beta	50,67	Leptin	interleukin-1beta	25608(Tax:10116)	24494(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	Leptin modulates the negative inotropic effect of interleukin-1beta in cardiac myocytes .
15719623	0	Leptin	0,6	interleukin-6	44,57	Leptin	interleukin-6	3952	3569	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Leptin in acute leukaemias : relationship to interleukin-6 and vascular_endothelial_growth_factor .
23622344	0	Leptin	0,6	interleukin-6	18,31	Leptin	interleukin-6	3952	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Leptin stimulates interleukin-6 production via janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 in rheumatoid synovial fibroblasts .
12643450	0	Leptin	0,6	leptin	8,14	Leptin	leptin	3952	3952	Gene	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Leptin , leptin resistance and endothelial_dysfunction in pre-eclampsia .
15950978	0	Leptin	0,6	leptin	42,48	Leptin	leptin	3952	3952	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Leptin receptor and functional effects of leptin in human endothelial progenitor cells .
17635573	0	Leptin	0,6	leptin	8,14	Leptin	leptin	3952	3952	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	Leptin , leptin soluble receptor and coronary_atherosclerosis .
18050615	0	Leptin	1,7	leptin	9,15	Leptin	leptin	3952	3952	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	-LSB- Leptin , leptin gene , leptin gene receptor polymorphisms and pregnancy -RSB- .
21584748	0	Leptin	0,6	leptin	8,14	Leptin	leptin	3952	3952	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Leptin , leptin gene and leptin_receptor gene polymorphism in heart_failure with preserved ejection fraction .
25010649	0	Leptin	0,6	leptin	47,53	Leptin	leptin	3952	3952	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Leptin as an uremic toxin : Deleterious role of leptin in chronic_kidney_disease .
9024259	0	Leptin	0,6	leptin	36,42	Leptin	leptin	3952	3952	Gene	Gene	START_ENTITY|dep|levels levels|compound|END_ENTITY	Leptin in human reproduction : serum leptin levels in pregnant and lactating women .
10329976	0	Leptin	0,6	leptin_receptor	42,57	Leptin	leptin receptor	25608(Tax:10116)	24536(Tax:10116)	Gene	Gene	responsiveness|amod|START_ENTITY responsiveness|nmod|mutation mutation|compound|END_ENTITY	Leptin responsiveness and gene dosage for leptin_receptor mutation -LRB- fa -RRB- in newborn rats .
11092515	0	Leptin	0,6	leptin_receptor	50,65	Leptin	leptin receptor	25608(Tax:10116)	24536(Tax:10116)	Gene	Gene	resistance|compound|START_ENTITY associated|nsubjpass|resistance associated|nmod|mRNA mRNA|compound|END_ENTITY	Leptin resistance is associated with hypothalamic leptin_receptor mRNA and protein downregulation .
14601735	0	Leptin	0,6	leptin_receptor	32,47	Leptin	leptin receptor	373955(Tax:9031)	374223(Tax:9031)	Gene	Gene	downregulate|nsubj|START_ENTITY downregulate|dobj|expression expression|compound|END_ENTITY	Leptin and insulin downregulate leptin_receptor gene expression in chicken-derived leghorn male hepatoma cells .
17400175	0	Leptin	0,6	leptin_receptor	117,132	Leptin	leptin receptor	16846(Tax:10090)	16847(Tax:10090)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|mice mice|nmod|form form|nmod|END_ENTITY	Leptin attenuates gene expression for renal 25-hydroxyvitamin_D3-1alpha-hydroxylase in mice via the long form of the leptin_receptor .
17010228	0	Leptin	0,6	lipase	44,50	Leptin	lipase	25608(Tax:10116)	291437(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat .
12882931	0	Leptin	0,6	lipoprotein_lipase	17,35	Leptin	lipoprotein lipase	3952	4023	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Leptin increases lipoprotein_lipase secretion by macrophages : involvement of oxidative stress and protein kinase C. Recent data suggest that plasma leptin may represent a cardiovascular_risk factor in diabetic patients .
21078910	0	Leptin	0,6	mammalian_target_of_rapamycin	95,124	Leptin	mammalian target of rapamycin	3952	2475	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Leptin modulates the survival of autoreactive CD4 + T cells through the nutrient/energy-sensing mammalian_target_of_rapamycin signaling pathway .
10102700	0	Leptin	0,6	neuropeptide_Y	51,65	Leptin	neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY identifies|nsubj|mRNA identifies|dobj|subpopulation subpopulation|nmod|neurons neurons|amod|END_ENTITY	Leptin receptor mRNA identifies a subpopulation of neuropeptide_Y neurons activated by fasting in rat hypothalamus .
15036374	0	Leptin	0,6	neuropeptide_Y	62,76	Leptin	neuropeptide Y	280836(Tax:9913)	504216(Tax:9913)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|effects effects|nmod|END_ENTITY	Leptin attenuates the acute effects of centrally administered neuropeptide_Y on somatotropin but not gonadotropin secretion in ovariectomized cows .
19009650	0	Leptin	0,6	neuropeptide_Y	100,114	Leptin	neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|orexin orexin|nmod|regulation regulation|nmod|+ +|acl|signaling signaling|nmod|neurons neurons|amod|END_ENTITY	Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2 + signaling in neuropeptide_Y neurons of the arcuate nucleus .
25198901	0	Leptin	0,6	oncostatin_M	15,27	Leptin	oncostatin M	3952	5008	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Leptin induces oncostatin_M production in osteoblasts by downregulating miR-93 through the Akt signaling pathway .
15979653	0	Leptin	0,6	p38	41,44	Leptin	p38	25608(Tax:10116)	81649(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells .
12957679	0	Leptin	0,6	paraoxonase_1	24,37	Leptin	paraoxonase 1	25608(Tax:10116)	84024(Tax:10116)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Leptin decreases plasma paraoxonase_1 -LRB- PON1 -RRB- activity and induces oxidative stress : the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia .
21317313	0	Leptin	0,6	peroxisome_proliferator-activated_receptor-y	85,129	Leptin	peroxisome proliferator-activated receptor-y	3952	5468	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	Leptin promotes fibroproliferative acute_respiratory_distress_syndrome by inhibiting peroxisome_proliferator-activated_receptor-y .
20738325	0	Leptin	0,6	peroxisome_proliferator-activated_receptor_a	50,94	Leptin	peroxisome proliferator-activated receptor a	25608(Tax:10116)	25747(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|pathway pathway|amod|END_ENTITY	Leptin induces hypertrophy through activating the peroxisome_proliferator-activated_receptor_a pathway in cultured neonatal rat cardiomyocytes .
16335797	0	Leptin	0,6	peroxisome_proliferator-activated_receptor_gamma	22,70	Leptin	peroxisome proliferator-activated receptor gamma	3952	5468	Gene	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Leptin down-regulates peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- mRNA levels in primary human monocyte-derived macrophages .
25047119	0	Leptin	0,6	phospholipase_D1	57,73	Leptin	phospholipase D1	16846(Tax:10090)	18805(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Leptin increases TNF-a expression and production through phospholipase_D1 in Raw 264.7 cells .
9392508	0	Leptin	0,6	pro-opiomelanocortin	30,50	Leptin	pro-opiomelanocortin	16846(Tax:10090)	18976(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus .
17082312	0	Leptin	0,6	signal_transducer_and_activator_of_transcription_3	64,114	Leptin	signal transducer and activator of transcription 3	25608(Tax:10116)	25125(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY reveals|nsubj|antagonist reveals|dobj|uncoupling uncoupling|nmod|responses responses|compound|signaling signaling|amod|END_ENTITY	Leptin antagonist reveals an uncoupling between leptin receptor signal_transducer_and_activator_of_transcription_3 signaling and metabolic responses with central leptin resistance .
23622344	0	Leptin	0,6	signal_transducer_and_activator_of_transcription_3	62,112	Leptin	signal transducer and activator of transcription 3	3952	6774	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Leptin stimulates interleukin-6 production via janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 in rheumatoid synovial fibroblasts .
15333742	0	Leptin	0,6	stearoyl-CoA_desaturase-1	47,72	Leptin	stearoyl-CoA desaturase-1	3952	6319	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Leptin and the control of metabolism : role for stearoyl-CoA_desaturase-1 -LRB- SCD-1 -RRB- .
20723213	0	Leptin	0,6	telomerase_reverse_transcriptase	99,131	Leptin	telomerase reverse transcriptase	3952	7015	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Leptin as a critical regulator of hepatocellular_carcinoma development through modulation of human telomerase_reverse_transcriptase .
25383655	0	Leptin_Receptor_Gene	21,41	LEPR	43,47	Leptin Receptor Gene	LEPR	3953	3953	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Serum Leptin Levels , Leptin_Receptor_Gene -LRB- LEPR -RRB- Polymorphism , and the Risk of Systemic_Lupus_Erythematosus in Kashmiri Population .
23558862	0	Leptin_receptor	0,15	leptin	49,55	Leptin receptor	leptin	3953	3952	Gene	Gene	mRNA|nsubj|START_ENTITY mRNA|dobj|concentration concentration|compound|END_ENTITY	Leptin_receptor -LRB- Ob-R -RRB- mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal_cancer .
22781587	0	Let-7b	0,6	growth_hormone_receptor	39,62	Let-7b	growth hormone receptor	777926(Tax:9031)	107049315	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Let-7b regulates the expression of the growth_hormone_receptor gene in deletion-type dwarf chickens .
23534758	0	Let-7c	0,6	HOXA1	54,59	Let-7c	HOXA1	406885	3198	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Let-7c inhibits NSCLC cell proliferation by targeting HOXA1 .
25197332	0	Let-7g	0,6	Aurora-B	71,79	Let-7g	Aurora-B	406890	9212	Gene	Gene	reverses|nsubj|START_ENTITY reverses|nmod|END_ENTITY	Let-7g reverses malignant phenotype of osteosarcoma cells by targeting Aurora-B .
20338660	0	Let-7g	0,6	collagen_type_I_alpha2	15,37	Let-7g	collagen type I alpha2	406890	1278	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Let-7g targets collagen_type_I_alpha2 and inhibits cell migration_in_hepatocellular_carcinoma .
25997616	0	Let-7i	0,6	Aurora-B	75,83	Let-7i	Aurora-B	406891	9212	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Let-7i inhibits the malignant phenotype of osteosarcoma cells by targeting Aurora-B .
23509825	0	Let-7i	70,76	miR-146a	85,93	Let-7i	miR-146a	406891	406938	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Helminth excreted/secreted antigens repress expression of LPS-induced Let-7i but not miR-146a and miR-155 in human dendritic cells .
8676862	0	LetD	109,113	CcdB	115,119	LetD	CcdB	6382275(Tax:562)	6276084(Tax:526563)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Co-induction of DNA relaxation and synthesis of DnaK and GroEL proteins in Escherichia_coli by expression of LetD -LRB- CcdB -RRB- protein , an inhibitor of DNA gyrase encoded by the F factor .
24379167	0	Lethal_hybrid_rescue	25,45	Lhr	47,50	Lethal hybrid rescue	Lhr	36957(Tax:7227)	36957(Tax:7227)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Allelic asymmetry of the Lethal_hybrid_rescue -LRB- Lhr -RRB- gene expression in the hybrid between Drosophila_melanogaster and D. _ simulans : confirmation by using genetic variations of D. _ melanogaster .
3259609	0	Leu-1	61,66	CD5	56,59	Leu-1	CD5	921	921	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Human monoclonal rheumatoid factor-like antibodies from CD5 -LRB- Leu-1 -RRB- + B cells are polyreactive .
2398277	0	Leu-13_antigen	96,110	TAPA-1	0,6	Leu-13 antigen	TAPA-1	8519	975	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	TAPA-1 , the target of an antiproliferative antibody , is associated on the cell surface with the Leu-13_antigen .
2472027	0	Leu-7	5,10	CD4	0,3	Leu-7	CD4	27087	920	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	CD4 + / Leu-7 + large granular lymphocytes in long-term renal allograft recipients .
1695560	0	Leu-7	9,14	CD8	4,7	Leu-7	CD8	27087	925	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	The CD8 + Leu-7 + subset of T cells in Crohn 's _ disease : distinction between cytotoxic and covert suppressor functions .
1696205	0	Leu-7	25,30	CD8	20,23	Leu-7	CD8	27087	925	Gene	Gene	+|compound|START_ENTITY lymphocytes|nsubj|+ +|dep|lymphocytes +|compound|END_ENTITY	Abnormally expanded CD8 + / Leu-7 + lymphocytes persisting in long-term bone marrow-transplanted patients are resting pre-cytotoxic T-lymphocytes .
1698559	0	Leu-7	65,70	CD8	60,63	Leu-7	CD8	27087	925	Gene	Gene	cells|nummod|START_ENTITY Induction|dep|cells Induction|nmod|+ +|compound|END_ENTITY	Induction of cytolytic function in resting peripheral blood CD8 + / Leu-7 + T cells through IL2/p 75 IL2-receptor interaction : a study in the allogeneic human bone marrow transplantation model .
2570740	0	Leu-8	63,68	CD4	57,60	Leu-8	CD4	6402	920	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Defective immunoregulation in primary_biliary_cirrhosis : CD4 + , Leu-8 + T cells have abnormal activation and suppressor function in vitro .
7515343	0	Leu-8	72,77	CD4	51,54	Leu-8	CD4	6402	920	Gene	Gene	receptor|compound|START_ENTITY bearing|dobj|receptor proliferation|acl|bearing proliferation|nmod|cells cells|compound|END_ENTITY	Defective proliferation and regulatory function of CD4 + T cells bearing Leu-8 homing receptor in primary_biliary_cirrhosis .
4069309	1	Leu-enkephalin	48,62	albumin	69,76	Leu-enkephalin	albumin	5173	213	Gene	Gene	interaction|amod|START_ENTITY interaction|compound|END_ENTITY	II : Leu-enkephalin serum albumin interaction .
3096877	0	Leu1	52,56	CD5	58,61	Leu1	CD5	921	921	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Phenotypic and functional characterization of human Leu1 -LRB- CD5 -RRB- B cells .
1712684	3	Leu8	558,562	CD4	554,557	Leu8	CD8	6402	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	In normal subjects , CD4 + Leu8 + cells are necessary for the initiation of the AMLR response , and sequentially lead to activation and proliferation of both CD4 + Leu8 - cells and CD8 + Leu8 + cells .
1725219	0	Leu8	174,178	CD4	138,141	Leu8	CD4	6402	920	Gene	Gene	regulated|nsubjpass|START_ENTITY expressing|ccomp|regulated expressing|nsubj|lymphocytes lymphocytes|appos|END_ENTITY	Pituitary-adrenal-immune system in normal subjects and in patients with anorexia_nervosa : the number of circulating helper T lymphocytes -LRB- CD4 -RRB- expressing the homing receptor Leu8 is regulated in part by pituitary-adrenal products .
23008432	0	LeuT	75,79	SGLT1	52,57	LeuT	SGLT1	3343	6523	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Simulated annealing reveals the kinetic activity of SGLT1 , a member of the LeuT structural family .
6363207	0	Leu_2	26,31	IS1	66,69	Leu 2	IS1	850342(Tax:4932)	20493545	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Regulation of yeast gene Leu_2 expression in Escherichia_coli by IS1 element -RSB- .
2787420	0	Leu_7	27,32	CD_4	20,24	Leu 7	CD 4	27087	920	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	-LSB- A novel phenotype -LRB- CD_4 + , Leu_7 + -RRB- in large_granular_lymphocyte_leukemia : a case report -RSB- .
6207141	0	Leu_7	16,21	HNK-1	23,28	Leu 7	HNK-1	27087	27087	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Distribution of Leu_7 -LRB- HNK-1 -RRB- antigen in human digestive organs : an immunohistochemical study with monoclonal antibody .
6344083	0	Leu_7	98,103	HNK-1	105,110	Leu 7	HNK-1	27087	27087	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Fluorescence-activated cell sorting of mouse-human hybrid cells aids in locating the gene for the Leu_7 -LRB- HNK-1 -RRB- antigen to human chromosome 11 .
2852081	0	Leu_7	50,55	HNK1	43,47	Leu 7	HNK1	27087	27087	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Flow cytometric and morphologic studies of HNK1 + -LRB- Leu_7 + -RRB- lymphocytes in relation to cytomegalovirus carrier status .
1371790	0	Leu_8	49,54	lymph_node_homing_receptor	21,47	Leu 8	lymph node homing receptor	6402	6402	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of human lymph_node_homing_receptor -LRB- Leu_8 -RRB- with the TCR/CD3 complex .
1701799	0	Leu_8	87,92	lymph_node_homing_receptor	49,75	Leu 8	lymph node homing receptor	6402	6402	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Monoclonal antibody against the human peripheral lymph_node_homing_receptor homologue -LRB- Leu_8 -RRB- inhibits B cell differentiation but not B cell proliferation .
26384650	0	Leucine-Rich_Repeat_Kinase_2	0,28	p53	52,55	Leucine-Rich Repeat Kinase 2	p53	120892	7157	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Leucine-Rich_Repeat_Kinase_2 -LRB- LRRK2 -RRB- phosphorylates p53 and induces p21 -LRB- WAF1/CIP1 -RRB- expression .
23275029	0	Leucine-Rich_Repeats_and_WD_Repeat_Domain_Containing_1	86,140	LRWD1	142,147	Leucine-Rich Repeats and WD Repeat Domain Containing 1	LRWD1	222229	222229	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Nuclear Factor - _ # 954 ; B -LRB- NF - _ # 954 ; B -RRB- Regulates the Expression of Human Testis-Enriched Leucine-Rich_Repeats_and_WD_Repeat_Domain_Containing_1 -LRB- LRWD1 -RRB- Gene .
24014121	0	Leucine-Rich_repeat_kinase_2	41,69	LRRK2	71,76	Leucine-Rich repeat kinase 2	LRRK2	120892	120892	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Patient-control association study of the Leucine-Rich_repeat_kinase_2 -LRB- LRRK2 -RRB- gene in South African Parkinson 's _ disease patients .
23912594	0	Leucine-rich_repeat-containing_G-protein_coupled_receptor_5	0,59	GPR49	60,65	Leucine-rich repeat-containing G-protein coupled receptor 5	GPR49	8549	8549	Gene	Gene	START_ENTITY|parataxis|activates activates|nsubj|END_ENTITY	Leucine-rich_repeat-containing_G-protein_coupled_receptor_5 / GPR49 activates G12/13-Rho GTPase pathway .
26646749	0	Leucine-rich_repeat_kinase_2	0,28	NF-kB_p50	82,91	Leucine-rich repeat kinase 2	NF-kB p50	120892	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Leucine-rich_repeat_kinase_2 positively regulates inflammation and down-regulates NF-kB_p50 signaling in cultured microglia cells .
25201882	0	Leucine-rich_repeat_kinase_2	0,28	Sec16A	39,45	Leucine-rich repeat kinase 2	Sec16A	120892	9919	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Leucine-rich_repeat_kinase_2 regulates Sec16A at ER exit sites to allow ER-Golgi export .
18322396	0	Leucine-rich_repeat_kinase_2	0,28	alpha-synuclein	46,61	Leucine-rich repeat kinase 2	alpha-synuclein	120892	6622	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	Leucine-rich_repeat_kinase_2 colocalizes with alpha-synuclein in Parkinson 's _ disease , but not tau-containing deposits in tauopathies .
19535993	0	Leucine-rich_repeat_kinase_2	0,28	alpha-synuclein	97,112	Leucine-rich repeat kinase 2	alpha-synuclein	120892	6622	Gene	Gene	expression|amod|START_ENTITY leads|nsubj|expression leads|xcomp|aggresome aggresome|dobj|formation formation|acl:relcl|associated associated|nmod|inclusions inclusions|amod|END_ENTITY	Leucine-rich_repeat_kinase_2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions .
20074637	0	Leucine-rich_repeat_kinase_2	0,28	alpha-synuclein	37,52	Leucine-rich repeat kinase 2	alpha-synuclein	120892	6622	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Leucine-rich_repeat_kinase_2 induces alpha-synuclein expression via the extracellular_signal-regulated_kinase pathway .
24360742	0	Leucine-rich_repeat_kinase_2	0,28	cyclooxygenase_2	39,55	Leucine-rich repeat kinase 2	cyclooxygenase 2	120892	5743	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Leucine-rich_repeat_kinase_2 modulates cyclooxygenase_2 and the inflammatory response in idiopathic and genetic Parkinson 's _ disease .
27039297	0	Leucine-rich_repeat_kinase_2	12,40	p50	100,103	Leucine-rich repeat kinase 2	p50	120892	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Erratum to : Leucine-rich_repeat_kinase_2 positively regulates inflammation and down-regulates NF-kB p50 signaling in cultured microglia cells .
25813822	0	Leucine_Zipper_Putative_Tumor_Suppressor_1	8,50	LZTS1	52,57	Leucine Zipper Putative Tumor Suppressor 1	LZTS1	11178	11178	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Loss of Leucine_Zipper_Putative_Tumor_Suppressor_1 -LRB- LZTS1 -RRB- Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary_Carcinoma .
133010	0	Leucocyte_migration_inhibition_factor	0,37	LIF	39,42	Leucocyte migration inhibition factor	LIF	3976	3976	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Leucocyte_migration_inhibition_factor -LRB- LIF -RRB- production by lymphocytes of normal children , newborns , and children with immune_deficiency .
22424774	0	Leucyl-tRNA_synthetase	0,22	TORC1	32,37	Leucyl-tRNA synthetase	TORC1	51520	23373	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Leucyl-tRNA_synthetase controls TORC1 via the EGO complex .
15670816	0	Leukaemia_inhibitory_factor	0,27	axotrophin	60,70	Leukaemia inhibitory factor	axotrophin	16878(Tax:10090)	57438(Tax:10090)	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	Leukaemia_inhibitory_factor -LRB- LIF -RRB- is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance .
11373293	0	Leukemia-associated_Rho_guanine_nucleotide_exchange_factor	0,58	Dbl	62,65	Leukemia-associated Rho guanine nucleotide exchange factor	Dbl	23365	4168	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Leukemia-associated_Rho_guanine_nucleotide_exchange_factor , a Dbl family protein found mutated in leukemia , causes transformation by activation of RhoA .
12084939	0	Leukemia_inhibitory_factor	0,26	STAT3	78,83	Leukemia inhibitory factor	STAT3	16878(Tax:10090)	20848(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|compound|END_ENTITY	Leukemia_inhibitory_factor inhibits neuronal terminal differentiation through STAT3 activation .
20014282	0	Leukemia_inhibitory_factor	0,26	STAT3	59,64	Leukemia inhibitory factor	STAT3	16878(Tax:10090)	20848(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Leukemia_inhibitory_factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells .
26271643	0	Leukemia_inhibitory_factor	0,26	STAT3	101,106	Leukemia inhibitory factor	STAT3	3976	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|growth growth|nmod|osteosarcoma osteosarcoma|nmod|END_ENTITY	Leukemia_inhibitory_factor promotes tumor growth and metastasis in human osteosarcoma via activating STAT3 .
9042332	0	Leukemia_inhibitory_factor	0,26	cytosolic_phospholipase_A2	46,72	Leukemia inhibitory factor	cytosolic phospholipase A2	3976	5321	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Leukemia_inhibitory_factor induces the 85-kDa cytosolic_phospholipase_A2 gene expression in cultured human bronchial epithelial cells .
7655023	0	Leukemia_inhibitory_factor	0,26	interleukin-8	35,48	Leukemia inhibitory factor	interleukin-8	3976	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Leukemia_inhibitory_factor induces interleukin-8 and monocyte_chemotactic_and_activating_factor in human monocytes : differential regulation by interferon-gamma .
12574225	0	Leukemia_inhibitory_factor	0,26	prolactin	37,46	Leukemia inhibitory factor	prolactin	3976	5617	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Leukemia_inhibitory_factor regulates prolactin secretion in prolactinoma and lactotroph cells .
11150513	0	Leukemia_inhibitory_factor	0,26	stat3	105,110	Leukemia inhibitory factor	stat3	3976	6774	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Leukemia_inhibitory_factor enhances mast cell growth in a mast cell/fibroblast co-culture system through stat3 signaling pathway of fibroblasts .
24585933	0	Leukocyte-associated_Ig-like_receptor-1	0,39	protein_D	86,95	Leukocyte-associated Ig-like receptor-1	protein D	3903	10202	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Leukocyte-associated_Ig-like_receptor-1 is a novel inhibitory receptor for surfactant protein_D .
12200076	0	Leukocyte-endothelial_cell_adhesion_molecule_1	0,46	LECAM-1	48,55	Leukocyte-endothelial cell adhesion molecule 1	LECAM-1	6402	6402	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Leukocyte-endothelial_cell_adhesion_molecule_1 -LRB- LECAM-1 -RRB- polymorphism is associated with diabetic_nephropathy in type_2_diabetes_mellitus .
8794952	0	Leukocyte_chemotactic_factor	0,28	CD4	50,53	Leukocyte chemotactic factor	CD4	3603	920	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Leukocyte_chemotactic_factor , a natural ligand to CD4 , is expressed by lymphocytes and microglial cells of the MS plaque .
19669929	0	Leukotactin-1	0,13	CCL15	14,19	Leukotactin-1	CCL15	6359	6359	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Leukotactin-1 / CCL15 induces cell migration and differentiation of human eosinophilic_leukemia EoL-1 cells through PKCdelta activation .
22396544	0	Leukotriene_B4_receptor-2	0,25	signal_transducer_and_activator_of_transcription_3	95,145	Leukotriene B4 receptor-2	signal transducer and activator of transcription 3	56413	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Leukotriene_B4_receptor-2 promotes invasiveness and metastasis of ovarian_cancer cells through signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- - dependent up-regulation of matrix_metalloproteinase_2 .
9565592	0	Leupaxin	0,8	PYK2	65,69	Leupaxin	PYK2	9404	2185	Gene	Gene	protein|nsubj|START_ENTITY protein|acl:relcl|forms forms|dobj|complex complex|nmod|END_ENTITY	Leupaxin is a novel LIM domain protein that forms a complex with PYK2 .
7678223	0	Lewisx	79,85	E-selectin	27,37	Lewisx	E-selectin	2526	6401	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of surface E-selectin and the effect of soluble ligand -LRB- sialyl Lewisx -RRB- on the half-life of E-selectin .
25220057	0	Lgl	0,3	Notch	14,19	Lgl	Notch	33156(Tax:7227)	31293(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	Lgl regulates Notch signaling via endocytosis , independently of the apical aPKC-Par6-Baz polarity complex .
24096609	0	Lgl	37,40	lethal_giant_larvae	16,35	Lgl	lethal giant larvae	16862(Tax:10090)	16862(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Distribution of lethal_giant_larvae -LRB- Lgl -RRB- protein in the tegument and negative impact of siRNA-based gene silencing on worm surface structure and egg hatching in Schistosoma_japonicum .
16210631	0	Lgp2	17,21	retinoic_acid-inducible_gene-I	79,109	Lgp2	retinoic acid-inducible gene-I	80861(Tax:10090)	230073(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic_acid-inducible_gene-I .
26429885	0	Lgr3	90,94	Dilp8	73,78	Lgr3	Dilp8	43098(Tax:7227)	39909(Tax:7227)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3 .
26510564	0	Lgr3	45,49	Dilp8	0,5	Lgr3	Dilp8	43098(Tax:7227)	39909(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing .
26332449	0	Lgr4	15,19	BMP-2	0,5	Lgr4	BMP-2	55366	650	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	BMP-2 Enhances Lgr4 Gene Expression in Osteoblastic Cells .
23712846	0	Lgr4	0,4	Sox2	110,114	Lgr4	Sox2	107515(Tax:10090)	20674(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2 .
26046762	0	Lgr5	9,13	Krt19	0,5	Lgr5	Krt19	8549	3880	Gene	Gene	Cells|compound|START_ENTITY Cells|amod|END_ENTITY	Krt19 -LRB- + -RRB- / Lgr5 -LRB- - -RRB- Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine .
20195621	0	Lgr5	14,18	beta-catenin	89,101	Lgr5	beta-catenin	8549	1499	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Lgr5 in human colorectal_carcinogenesis and its potential correlation with beta-catenin .
19416211	0	Lgr8	21,25	Rxfp2	14,19	Lgr8	Rxfp2	140498(Tax:10090)	140498(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of Rxfp2 -LRB- Lgr8 -RRB- expression in the mouse fetal kidney by the transcription factor Pod1 -LRB- Tcf_21 -RRB- .
23536856	0	Lhb	16,19	NR5A2	0,5	Lhb	NR5A2	16866(Tax:10090)	26424(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro , but is dispensable for gonadotropin synthesis and fertility in vivo .
24379167	0	Lhr	47,50	Lethal_hybrid_rescue	25,45	Lhr	Lethal hybrid rescue	36957(Tax:7227)	36957(Tax:7227)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Allelic asymmetry of the Lethal_hybrid_rescue -LRB- Lhr -RRB- gene expression in the hybrid between Drosophila_melanogaster and D. _ simulans : confirmation by using genetic variations of D. _ melanogaster .
17331196	0	Lhx3	0,4	Pou4f3	57,63	Lhx3	Pou4f3	16871(Tax:10090)	18998(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Lhx3 , a LIM domain transcription factor , is regulated by Pou4f3 in the auditory but not in the vestibular system .
9286712	0	Lhx4	0,4	LIM	8,11	Lhx4	LIM	16872(Tax:10090)	56376(Tax:10090)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Lhx4 , a LIM homeobox gene .
24742460	0	Lhx6	0,4	Arx	24,27	Lhx6	Arx	26468	170302	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position .
21658586	0	Lhx6	0,4	Shh	57,60	Lhx6	Shh	26468	6469	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors .
1477476	0	Lif	44,47	leukemia_inhibition_factor	11,37	Lif	leukemia inhibition factor	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The murine leukemia_inhibition_factor gene -LRB- Lif -RRB- is located on proximal chromosome 11 , not chromosome 13 .
10679327	0	Lif1p	0,5	Lig4p	29,34	Lif1p	Lig4p	852790(Tax:4932)	3981	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks .
10679327	0	Lig4p	29,34	Lif1p	0,5	Lig4p	Lif1p	3981	852790(Tax:4932)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Lif1p targets the DNA ligase Lig4p to sites of DNA double-strand breaks .
8001783	0	Lighten_up	4,14	Lip	16,19	Lighten up	Lip	40739(Tax:7227)	40739(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Lighten_up -LRB- Lip -RRB- gene of Drosophila_melanogaster , a modifier of retroelement expression , position effect variegation and white locus insertion alleles .
11290961	0	Lim2	64,68	MP19	53,57	Lim2	MP19	233187(Tax:10090)	233187(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse lens fiber-cell intrinsic membrane protein MP19 gene -LRB- Lim2 -RRB- and granule membrane protein GMP-17 gene -LRB- Nkg7 -RRB- : Isolation and sequence analysis of two neighboring genes .
9417918	0	Limatin	0,7	LIM	35,38	Limatin	LIM	3983	10611	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Limatin -LRB- LIMAB1 -RRB- , an actin-binding LIM protein , maps to mouse chromosome 19 and human chromosome 10q25 , a region frequently deleted in human cancers .
22540148	0	Lin28	63,68	Aire	0,4	Lin28	Aire	79727	326	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Aire promotes the self-renewal of embryonic stem cells through Lin28 .
23255092	0	Lin28	0,5	BMP4	16,20	Lin28	BMP4	79727	652	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Lin28 regulates BMP4 and functions with Oct4 to affect ovarian_tumor microenvironment .
22713243	0	Lin28	0,5	HER2	16,20	Lin28	HER2	79727	2064	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Lin28 regulates HER2 and promotes malignancy through multiple mechanisms .
23255092	0	Lin28	0,5	Oct4	40,44	Lin28	Oct4	79727	5460	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Lin28 regulates BMP4 and functions with Oct4 to affect ovarian_tumor microenvironment .
19713958	0	Lin28	0,5	Zcchc11	26,33	Lin28	Zcchc11	83557(Tax:10090)	230594(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells .
26944953	0	Lin28A	0,6	Her2	47,51	Lin28A	Her2	79727	2064	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Lin28A and androgen_receptor expression in ER - / Her2 + _ breast_cancer .
26158423	0	Lin28B	43,49	IMP3	63,67	Lin28B	IMP3	389421	55272	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 -LRB- IMP3 -RRB- is associated with chemoresistance and poor disease outcome in ovarian_cancer .
23494474	0	Lin28B	34,40	TF_II_D	56,63	Lin28B	TF II D	389421	6908	Gene	Gene	START_ENTITY|acl|activating activating|dobj|END_ENTITY	The oncoprotein HBXIP upregulates Lin28B via activating TF_II_D to promote proliferation of breast_cancer cells .
25753579	0	Lin28b	0,6	Arid3a	71,77	Lin28b	Arid3a	380669(Tax:10090)	13496(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a .
20404087	0	Lin9	0,4	DREAM	33,38	Lin9	DREAM	286826	30818	Gene	Gene	START_ENTITY|appos|subunit subunit|nmod|complex complex|compound|END_ENTITY	Lin9 , a subunit of the mammalian DREAM complex , is essential for embryonic development , for survival of adult mice , and for tumor suppression .
26656491	0	Linc-RoR	0,8	c-Myc	18,23	Linc-RoR	c-Myc	100885779	4609	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Linc-RoR promotes c-Myc expression through hnRNP_I and AUF1 .
26656491	0	Linc-RoR	0,8	hnRNP_I	43,50	Linc-RoR	hnRNP I	100885779	5725	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Linc-RoR promotes c-Myc expression through hnRNP_I and AUF1 .
8001783	0	Lip	16,19	Lighten_up	4,14	Lip	Lighten up	40739(Tax:7227)	40739(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Lighten_up -LRB- Lip -RRB- gene of Drosophila_melanogaster , a modifier of retroelement expression , position effect variegation and white locus insertion alleles .
26212120	0	LipN	20,24	Rv2970c	26,33	LipN	Rv2970c	887194(Tax:83332)	887194(Tax:83332)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of LipN -LRB- Rv2970c -RRB- of Mycobacterium_Tuberculosis_H37Rv and Its Probable Role in Xenobiotic Degradation .
25035425	0	Lipase_maturation_factor_1	0,26	Atf6a	121,126	Lipase maturation factor 1	Atf6a	76483(Tax:10090)	226641(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Lipase_maturation_factor_1 -LRB- lmf1 -RRB- is induced by endoplasmic reticulum stress through activating_transcription_factor_6a -LRB- Atf6a -RRB- signaling .
23926469	0	Lipid_Binding_Protein	14,35	PERF15	49,55	Lipid Binding Protein	PERF15	646480	646480	Gene	Gene	Gene|compound|START_ENTITY Gene|dep|END_ENTITY	A Novel Human Lipid_Binding_Protein Coding Gene : PERF15 , Sequence and Cloning .
24955089	0	Lipid_Phosphate_Phosphohydrolase_1	73,107	Peroxisome_Proliferator-Activated_Receptor_y	0,44	Lipid Phosphate Phosphohydrolase 1	Peroxisome Proliferator-Activated Receptor y	8611	5468	Gene	Gene	Expression|nmod|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_y Regulates the Expression of Lipid_Phosphate_Phosphohydrolase_1 in Human Vascular Endothelial Cells .
23627357	0	Lipin1	0,6	PPARy	17,22	Lipin1	PPARy	23175	5468	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Lipin1 regulates PPARy transcriptional activity .
24382649	0	Lipocalin-2	0,11	Lcn2	13,17	Lipocalin-2	Lcn2	170496(Tax:10116)	170496(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lipocalin-2 -LRB- Lcn2 -RRB- expression is mediated by maternal nutrition during the development of the fetal liver .
25086218	0	Lipocalin-2	0,11	PLIN5	29,34	Lipocalin-2	PLIN5	16819(Tax:10090)	66968(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Lipocalin-2 -LRB- LCN2 -RRB- regulates PLIN5 expression and intracellular lipid droplet formation in the liver .
23696034	0	Lipocalin-2	0,11	epidermal_growth_factor	114,137	Lipocalin-2	epidermal growth factor	3934	1950	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular_carcinoma through the epidermal_growth_factor -LRB- TGF-beta1 -RRB- / Lcn2/Twist1 pathway .
19009554	0	Lipocalin-2	0,11	interleukin-1beta	26,43	Lipocalin-2	interleukin-1beta	16819(Tax:10090)	16176(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Lipocalin-2 is induced by interleukin-1beta in murine adipocytes in vitro .
18190883	0	Lipocalin-2	70,81	neutrophil_gelatinase-B_associated_lipocalin	18,62	Lipocalin-2	neutrophil gelatinase-B associated lipocalin	3934	3934	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The novel role of neutrophil_gelatinase-B_associated_lipocalin -LRB- NGAL -RRB- / Lipocalin-2 as a biomarker for lupus_nephritis .
19560454	0	Lipopolysaccharide-binding_protein	0,34	LBP	36,39	Lipopolysaccharide-binding protein	LBP	3929	3929	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lipopolysaccharide-binding_protein -LRB- LBP -RRB- gene polymorphisms : rapid genotyping by real-time PCR and association with infective_endocarditis .
16105094	0	Lipopolysaccharide-binding_protein	0,34	interleukin-6	68,81	Lipopolysaccharide-binding protein	interleukin-6	3929	3569	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Lipopolysaccharide-binding_protein down-regulates the expression of interleukin-6 by human gingival fibroblast .
9396923	0	Lipopolysaccharide_binding_protein	0,34	CD14	47,51	Lipopolysaccharide binding protein	CD14	3929	929	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Lipopolysaccharide_binding_protein and soluble CD14 receptor protein in amniotic fluid and cord blood in patients at term .
19500354	0	Lipoprotein-associated_phospholipase_A2	0,39	Lp-PLA2	41,48	Lipoprotein-associated phospholipase A2	Lp-PLA2	7941	7941	Gene	Gene	activity|nummod|START_ENTITY activity|compound|END_ENTITY	Lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity , platelet-activating factor acetylhydrolase -LRB- PAF-AH -RRB- in leukocytes and body composition in healthy adults .
12690214	0	Lipoprotein_lipase	0,18	LPL	20,23	Lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lipoprotein_lipase -LRB- LPL -RRB- gene variation and progression of carotid_artery_plaque .
24703657	0	Lipoprotein_lipase	8,26	LPL	28,31	Lipoprotein lipase	LPL	4023	4023	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	A novel Lipoprotein_lipase -LRB- LPL -RRB- agonist rescues the enzyme from inhibition by angiopoietin-like_4 -LRB- ANGPTL4 -RRB- .
2765502	0	Lipoprotein_lipase	0,18	THP-1	38,43	Lipoprotein lipase	THP-1	4023	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Lipoprotein_lipase gene expression in THP-1 cells .
7538426	0	Lipoprotein_lipase	0,18	interferon_gamma	35,51	Lipoprotein lipase	interferon gamma	4023	3458	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Lipoprotein_lipase synergizes with interferon_gamma to induce macrophage nitric_oxide synthetase mRNA expression and nitric_oxide production .
11836260	0	Liprin_beta_1	0,13	Mts1	164,168	Liprin beta 1	Mts1	8496	6275	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Liprin_beta_1 , a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins , is a new target for the metastasis-associated_protein_S100A4 -LRB- Mts1 -RRB- .
11825870	0	Liquid_facets	60,73	Fat_facets	94,104	Liquid facets	Fat facets	38846(Tax:7227)	43749(Tax:7227)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	A specific protein substrate for a deubiquitinating enzyme : Liquid_facets is the substrate of Fat_facets .
11734602	0	Lis1	21,25	NudC	0,4	Lis1	NudC	5048	10726	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	NudC associates with Lis1 and the dynein motor at the leading pole of neurons .
14970193	0	Lis1	68,72	Nudel	0,5	Lis1	Nudel	5048	81565	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein .
9697693	0	Lis1	30,34	Pafah1b1	20,28	Lis1	Pafah1b1	18472(Tax:10090)	18472(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Graded reduction of Pafah1b1 -LRB- Lis1 -RRB- activity results in neuronal migration defects and early embryonic_lethality .
21521687	0	Liver-enriched_inhibitory_protein	0,33	histone_deacetylase_1	95,116	Liver-enriched inhibitory protein	histone deacetylase 1	23049	3065	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Liver-enriched_inhibitory_protein -LRB- LIP -RRB- actively inhibits preadipocyte differentiation through histone_deacetylase_1 -LRB- HDAC1 -RRB- .
22676223	0	Liver-intestine_cadherin	0,24	epidermal_growth_factor_receptor	38,70	Liver-intestine cadherin	epidermal growth factor receptor	1015	1956	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Liver-intestine_cadherin induction by epidermal_growth_factor_receptor is associated with intestinal differentiation of gastric_cancer .
25084760	0	Liver_X_Receptor	56,72	LXR	74,77	Liver X Receptor	LXR	22259(Tax:10090)	22259(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|appos|END_ENTITY	Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver_X_Receptor -LRB- LXR -RRB- Pathway by Activating Small Guanosine_Triphosphate-Binding Proteins -LRB- sGTPases -RRB- in Neuronal Cells .
19036902	0	Liver_X_receptor-alpha	0,22	proopiomelanocortin	33,52	Liver X receptor-alpha	proopiomelanocortin	58852(Tax:10116)	24664(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	Liver_X_receptor-alpha regulates proopiomelanocortin -LRB- POMC -RRB- gene transcription in the pituitary .
23041609	0	Liver_X_receptor_a	0,18	CYP1A1	56,62	Liver X receptor a	CYP1A1	10062	1543	Gene	Gene	transactivates|nsubj|START_ENTITY transactivates|dobj|END_ENTITY	Liver_X_receptor_a bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes .
22226967	0	Liver_kinase_B1	0,15	LKB1	28,32	Liver kinase B1	LKB1	6794	6794	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Liver_kinase_B1 expression -LRB- LKB1 -RRB- is repressed by estrogen_receptor_alpha -LRB- ERa -RRB- in MCF-7 human breast_cancer cells .
15181096	0	Liver_receptor_homolog-1	0,24	steroidogenic_acute_regulatory_protein	53,91	Liver receptor homolog-1	steroidogenic acute regulatory protein	2494	6770	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Liver_receptor_homolog-1 regulates the expression of steroidogenic_acute_regulatory_protein in human granulosa cells .
18270374	0	Liver_receptor_homolog_1	0,24	bile_salt_export_pump	59,80	Liver receptor homolog 1	bile salt export pump	2494	8647	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Liver_receptor_homolog_1 transcriptionally regulates human bile_salt_export_pump expression .
11024045	0	Livin	0,5	inhibitor_of_apoptosis_protein	15,45	Livin	inhibitor of apoptosis protein	79444	84061	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Livin , a novel inhibitor_of_apoptosis_protein family member .
20717925	0	Livin	26,31	mTOR	58,62	Livin	mTOR	79444	21977(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY enhances|dobj|synthesis enhances|nmod|END_ENTITY	VEGF stimulation enhances Livin protein synthesis through mTOR signaling .
21378336	0	Lkb1	48,52	Stk11	41,46	Lkb1	Stk11	314621(Tax:10116)	314621(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations and aberrant transcriptions of Stk11 -LRB- Lkb1 -RRB- gene in rat liver_tumors .
20972424	0	Lkb1	61,65	mTORC1	23,29	Lkb1	mTORC1	20869(Tax:10090)	382056(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Primary cilia regulate mTORC1 activity and cell size through Lkb1 .
16278673	0	Lkb1	76,80	p53	83,86	Lkb1	p53	20869(Tax:10090)	22060(Tax:10090)	Gene	Gene	+|amod|START_ENTITY carcinomas|nmod|+ onsets|dep|carcinomas onsets|parataxis|/ /|dep|END_ENTITY	Accelerated onsets of gastric_hamartomas and hepatic_adenomas / carcinomas in Lkb1 + / - p53 - / - compound mutant mice .
21266325	0	Lkb1	12,16	pro-opiomelanocortin	20,40	Lkb1	pro-opiomelanocortin	20869(Tax:10090)	18976(Tax:10090)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice .
8565641	0	Llglh	34,39	LLGL	46,50	Llglh	LLGL	16897(Tax:10090)	16897(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human homologue of the murine Llglh gene -LRB- LLGL -RRB- maps within the Smith-Magenis_syndrome region in 17p11 .2 .
12067721	0	Lmo2	23,27	AF6	37,40	Lmo2	AF6	4005	4301	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The LIM domain protein Lmo2 binds to AF6 , a translocation partner of the MLL oncogene .
22222369	0	Lmo2	120,124	LIM_domain_only_2	101,118	Lmo2	LIM domain only 2	4005	4005	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Nuclear localization of lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- and its role in regulating LIM_domain_only_2 -LRB- Lmo2 -RRB- gene .
26156403	0	Lmo3	10,14	Hen2	31,35	Lmo3	Hen2	109593(Tax:10090)	18072(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice .
21525034	0	Lmo7	16,20	Pax3	36,40	Lmo7	Pax3	4008	5077	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes .
24010014	0	Lmo7	40,44	p130Cas	78,85	Lmo7	p130Cas	4008	9564	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions .
24194952	0	Lmx1a	65,70	DNA-dependent_protein_kinase	0,28	Lmx1a	DNA-dependent protein kinase	110648(Tax:10090)	19090(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	DNA-dependent_protein_kinase is a context dependent regulator of Lmx1a and midbrain specification .
11375911	0	Lmx1a	42,47	Dreher	34,40	Lmx1a	Dreher	110648(Tax:10090)	110648(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Neuronal migration defects in the Dreher -LRB- Lmx1a -RRB- mutant mouse : role of disorders of the glial limiting membrane .
20035737	0	Lmx1a	0,5	Foxa2	31,36	Lmx1a	Foxa2	110648(Tax:10090)	15376(Tax:10090)	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon .
17166916	0	Lmx1b	0,5	Fgf8	23,27	Lmx1b	Fgf8	16917(Tax:10090)	14179(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice .
19562271	0	Lmx1b	53,58	NPHS2	43,48	Lmx1b	NPHS2	4010	7827	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	The transcriptional regulation of podocin -LRB- NPHS2 -RRB- by Lmx1b and a promoter single nucleotide polymorphism .
20333234	0	Lnk	89,92	SH2B	75,79	Lnk	SH2B	43130(Tax:7227)	43130(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Regulation of lifespan , metabolism , and stress responses by the Drosophila SH2B protein , Lnk .
21496118	0	Lnk	29,32	SH2B3	34,39	Lnk	SH2B3	10019	10019	Gene	Gene	transfer|nmod|START_ENTITY transfer|appos|END_ENTITY	Gene transfer of the adaptor Lnk -LRB- SH2B3 -RRB- prevents porcine endothelial cell activation and apoptosis : implication for xenograft 's cytoprotection .
17007883	0	Lnk	18,21	TNF-alpha	0,9	Lnk	TNF-alpha	10019	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells .
16644735	0	Lnk	21,24	VCAM-1	84,90	Lnk	VCAM-1	10019	7412	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The adaptor molecule Lnk negatively regulates tumor_necrosis_factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1_and _ -2 pathways .
18588518	0	Lnk	16,19	c-Kit	48,53	Lnk	c-Kit	10019	3815	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Adaptor protein Lnk associates with Tyr -LRB- 568 -RRB- in c-Kit .
23213426	0	Lola	0,4	glutamate_receptor	15,33	Lola	glutamate receptor	44548(Tax:7227)	33275(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Lola regulates glutamate_receptor expression at the Drosophila neuromuscular junction .
25128872	0	Lon_protease	25,37	Sirtuin_3	0,9	Lon protease	Sirtuin 3	9361	23410	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sirtuin_3 interacts with Lon_protease and regulates its acetylation status .
20308079	0	Long_chain_acyl-CoA_synthetase-3	0,32	peroxisome_proliferator-activated_receptor_delta	59,107	Long chain acyl-CoA synthetase-3	peroxisome proliferator-activated receptor delta	2181	5467	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Long_chain_acyl-CoA_synthetase-3 is a molecular target for peroxisome_proliferator-activated_receptor_delta in HepG2 hepatoma cells .
19346254	0	Lot1	0,4	pituitary_adenylate_cyclase-activating_polypeptide	29,79	Lot1	pituitary adenylate cyclase-activating polypeptide	25157(Tax:10116)	24166(Tax:10116)	Gene	Gene	element|dep|START_ENTITY element|nmod|END_ENTITY	Lot1 is a key element of the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- / cyclic_AMP pathway that negatively regulates neuronal precursor proliferation .
25196457	0	Low-Density_Lipoprotein_Receptor	31,63	Raf-1	131,136	Low-Density Lipoprotein Receptor	Raf-1	300438(Tax:10116)	24703(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Berberine Up-Regulates Hepatic Low-Density_Lipoprotein_Receptor through Ras-Independent but AMP-Activated Protein Kinase-Dependent Raf-1 Activation .
11137106	0	Low-density_lipoprotein_receptor	0,32	LDLR	39,43	Low-density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Low-density_lipoprotein_receptor gene -LRB- LDLR -RRB- world-wide website in familial_hypercholesterolaemia : update , new features and mutation analysis .
6501314	0	Low-density_lipoprotein_receptor	0,32	apolipoprotein_B	86,102	Low-density lipoprotein receptor	apolipoprotein B	3949	338	Gene	Gene	determinants|amod|START_ENTITY switch|nsubj|determinants switch|xcomp|END_ENTITY	Low-density_lipoprotein_receptor binding determinants switch from apolipoprotein_E to apolipoprotein_B during conversion of hypertriglyceridemic very-low-density lipoprotein to low-density lipoproteins .
11336703	0	Low-density_lipoprotein_receptor-related_protein-5	0,50	Axin	60,64	Low-density lipoprotein receptor-related protein-5	Axin	4041	8312	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Low-density_lipoprotein_receptor-related_protein-5 binds to Axin and regulates the canonical Wnt signaling pathway .
19810105	0	Low-density_lipoprotein_receptor-related_protein_5	0,50	LRP5	52,56	Low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- expression in human osteoarthritic chondrocytes .
25097526	0	Low_Density_Lipoprotein_Receptor	42,74	LDL-R	76,81	Low Density Lipoprotein Receptor	LDL-R	3949	3949	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single step PCR for the identification of Low_Density_Lipoprotein_Receptor -LRB- LDL-R -RRB- gene mutations .
11668627	0	Low_density_lipoprotein_receptor	0,32	familial_hypercholesterolemia	81,110	Low density lipoprotein receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene mutations in Canadian subjects with familial_hypercholesterolemia , but not of French descent .
6290485	0	Low_density_lipoprotein_receptor	0,32	familial_hypercholesterolemia	56,85	Low density lipoprotein receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Low_density_lipoprotein_receptor activity in homozygous familial_hypercholesterolemia fibroblasts .
8095446	0	Lox	30,33	lysyl_oxidase	10,23	Lox	lysyl oxidase	16948(Tax:10090)	16948(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse lysyl_oxidase gene -LRB- Lox -RRB- resides on chromosome 18 .
16384560	0	Lox-1	77,82	ERK1/2	62,68	Lox-1	ERK1/2	4973	5595;5594	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	Low-density lipoprotein oxidized to various degrees activates ERK1/2 through Lox-1 .
12111211	0	Lozenge	14,21	Yan	0,3	Lozenge	Yan	31883(Tax:7227)	33392(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Yan regulates Lozenge during Drosophila eye development .
21241231	0	Lp-PLA	53,59	lipoprotein-associated_phospholipase_A2	12,51	Lp-PLA	lipoprotein-associated phospholipase A2	7941	7941	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA -RRB- in cardiovascular_disease .
19500354	0	Lp-PLA2	41,48	Lipoprotein-associated_phospholipase_A2	0,39	Lp-PLA2	Lipoprotein-associated phospholipase A2	7941	7941	Gene	Gene	activity|compound|START_ENTITY activity|nummod|END_ENTITY	Lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity , platelet-activating factor acetylhydrolase -LRB- PAF-AH -RRB- in leukocytes and body composition in healthy adults .
19500354	0	Lp-PLA2	41,48	PAF-AH	104,110	Lp-PLA2	PAF-AH	7941	7941	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity , platelet-activating factor acetylhydrolase -LRB- PAF-AH -RRB- in leukocytes and body composition in healthy adults .
17928209	0	Lp-PLA2	102,109	lipoprotein-associated_phospholipase_A2	61,100	Lp-PLA2	lipoprotein-associated phospholipase A2	7941	7941	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of a low-calorie diet associated with weight_loss on lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity in healthy obese women .
23413990	0	Lp-PLA2	92,99	lipoprotein-associated_phospholipase_A2	51,90	Lp-PLA2	lipoprotein-associated phospholipase A2	7941	7941	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Influence of obesity and cardiometabolic makers on lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity in adolescents : the healthy young cross-sectional study .
18560444	0	Lpa	114,117	lipoprotein_a	99,112	Lpa	lipoprotein a	4018	4018	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Genome-wide linkage analysis for identifying quantitative trait loci involved in the regulation of lipoprotein_a -LRB- Lpa -RRB- levels .
11254124	0	Lpe10p	41,47	Mrs2p	64,69	Lpe10p	Mrs2p	856045(Tax:4932)	854511(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The mitochondrial inner membrane protein Lpe10p , a homologue of Mrs2p , is essential for magnesium homeostasis and group II intron splicing in yeast .
22055193	0	Lpin1	30,35	p53	13,16	Lpin1	p53	14245(Tax:10090)	22060(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	ROS-mediated p53 induction of Lpin1 regulates fatty_acid oxidation in response to nutritional stress .
21757706	0	Lpl0329	141,148	Lpl0330	41,48	Lpl0329	Lpl0330	3114060(Tax:297245)	3116235(Tax:297245)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	The atypical two-component sensor kinase Lpl0330 from Legionella_pneumophila controls the bifunctional diguanylate cyclase-phosphodiesterase Lpl0329 to modulate bis - -LRB- 3 ' -5 ' -RRB- - cyclic_dimeric_GMP synthesis .
21757706	0	Lpl0330	41,48	Lpl0329	141,148	Lpl0330	Lpl0329	3116235(Tax:297245)	3114060(Tax:297245)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	The atypical two-component sensor kinase Lpl0330 from Legionella_pneumophila controls the bifunctional diguanylate cyclase-phosphodiesterase Lpl0329 to modulate bis - -LRB- 3 ' -5 ' -RRB- - cyclic_dimeric_GMP synthesis .
11580836	0	Lre1	0,4	Cbk1	104,108	Lre1	Cbk1	850306(Tax:4932)	855561(Tax:4932)	Gene	Gene	affects|nsubj|START_ENTITY affects|xcomp|chitinase chitinase|nmod|inhibition inhibition|nmod|kinase kinase|amod|END_ENTITY	Lre1 affects chitinase expression , trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces_cerevisiae .
23954433	0	Lre1	0,4	Cbk1	43,47	Lre1	Cbk1	850306(Tax:4932)	855561(Tax:4932)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner .
12837754	0	Lrh-1	55,60	Abcc3	70,75	Lrh-1	Abcc3	26424(Tax:10090)	76408(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Tumor_necrosis_factor_alpha-dependent up-regulation of Lrh-1 and Mrp3 -LRB- Abcc3 -RRB- reduces liver_injury in obstructive cholestasis .
18848351	0	Lrp4	0,4	Agrin	23,28	Lrp4	Agrin	4038	375790	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Lrp4 is a receptor for Agrin and forms a complex with MuSK .
21969364	0	Lrp4	40,44	Agrin	0,5	Lrp4	Agrin	4038	375790	Gene	Gene	protein|amod|START_ENTITY region|nmod|protein binds|nmod|region binds|nsubj|END_ENTITY	Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific_kinase -LRB- MuSK -RRB- .
21969364	0	Lrp4	88,92	Agrin	0,5	Lrp4	Agrin	4038	375790	Gene	Gene	protein|nmod|START_ENTITY region|nmod|protein binds|nmod|region binds|nsubj|END_ENTITY	Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific_kinase -LRB- MuSK -RRB- .
19936252	0	Lrp4	0,4	Dickkopf_1	27,37	Lrp4	Dickkopf 1	228357(Tax:10090)	13380(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Lrp4 , a novel receptor for Dickkopf_1 and sclerostin , is expressed by osteoblasts and regulates bone growth and turnover in vivo .
21969364	0	Lrp4	40,44	Lrp4	88,92	Lrp4	Lrp4	4038	4038	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific_kinase -LRB- MuSK -RRB- .
21969364	0	Lrp4	88,92	Lrp4	40,44	Lrp4	Lrp4	4038	4038	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific_kinase -LRB- MuSK -RRB- .
16434236	0	Lrp4	66,70	low_density_lipoprotein_receptor-related_protein_4	14,64	Lrp4	low density lipoprotein receptor-related protein 4	228357(Tax:10090)	228357(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of low_density_lipoprotein_receptor-related_protein_4 -LRB- Lrp4 -RRB- gene in the mouse germ cells .
25406935	0	Lrp6	61,65	Cdo	0,3	Lrp6	Cdo	4040	1036	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation .
23751912	0	Lrrc10	0,6	Nkx2-5	50,56	Lrrc10	Nkx2-5	237560(Tax:10090)	18091(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4 .
24991885	0	Lrrc34	0,6	Npm1	50,54	Lrrc34	Npm1	151827	4869	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	Lrrc34 , a Novel Nucleolar Protein , Interacts with Npm1 and Ncl and Has an Impact on Pluripotent Stem Cells .
23880186	0	Lrrfip1	29,36	microRNA_miR-132	4,20	Lrrfip1	microRNA miR-132	367314(Tax:10116)	100314029(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	The microRNA_miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia .
19878656	0	Lrrk2	0,5	alpha-synuclein	23,38	Lrrk2	alpha-synuclein	120892	6622	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Lrrk2 interaction with alpha-synuclein in diffuse_Lewy_body_disease .
17611037	0	Lrrk2	56,61	leucine-rich_repeat_kinase_2	26,54	Lrrk2	leucine-rich repeat kinase 2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A comparative analysis of leucine-rich_repeat_kinase_2 -LRB- Lrrk2 -RRB- expression in mouse brain and Lewy_body_disease .
15081109	0	Lsamp	98,103	limbic_system-associated_membrane_protein	55,96	Lsamp	limbic system-associated membrane protein	268890(Tax:10090)	268890(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the genomic structure of the mouse limbic_system-associated_membrane_protein -LRB- Lsamp -RRB- gene .
15651983	0	Lsb5p	0,5	Sla1p	38,43	Lsb5p	Sla1p	850323(Tax:4932)	852276(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Lsb5p interacts with actin regulators Sla1p and Las17p , ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes .
7964512	0	Lsk	22,25	IL-4	0,4	Lsk	IL-4	4145	3565	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	IL-4 and IL-13 induce Lsk , a Csk-like tyrosine kinase , in human monocytes .
19014439	0	Luc7	73,77	Prp40	41,46	Luc7	Prp40	851471(Tax:4932)	853857(Tax:4932)	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71 .
26503158	0	Luman	0,5	DC-STAMP	66,74	Luman	DC-STAMP	10488	81501	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression , stability and localization .
15705566	0	Luman	97,102	Zhangfei	0,8	Luman	Zhangfei	10488	58487	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman .
20403257	0	Lun	65,68	Ding	45,49	Lun	Ding	10210	6045	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Healthcare in marriage and pregnancy in Tai Ding Yang Sheng Zhu Lun -RSB- .
17242461	0	Lungkine	22,30	CXCL15	14,20	Lungkine	CXCL15	20309(Tax:10090)	20309(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CXCL15 -LRB- Lungkine -RRB- in murine gastrointestinal , urogenital , and endocrine organs .
2114646	0	Luteinizing_hormone-releasing_hormone	0,37	Fos	54,57	Luteinizing hormone-releasing hormone	Fos	25194(Tax:10116)	314322(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY express|nsubj|neurons express|dobj|protein protein|compound|END_ENTITY	Luteinizing_hormone-releasing_hormone neurons express Fos protein during the proestrous surge of luteinizing hormone .
6372946	0	Luteinizing_hormone-releasing_hormone	0,37	LH-RH	39,44	Luteinizing hormone-releasing hormone	LH-RH	2796	2796	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- cells and their projections in the forebrain of the bat Myotis lucifugus lucifugus .
23418666	0	Luteinizing_hormone-releasing_hormone	0,37	LHRH	39,43	Luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptor agonists vs antagonists : a matter of the receptors ?
20430510	0	Luteinizing_hormone_beta-subunit	0,32	LHbeta	39,45	Luteinizing hormone beta-subunit	LHbeta	3972	3972	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Luteinizing_hormone_beta-subunit gene -LRB- LHbeta -RRB- polymorphism in infertility and endometriosis-associated infertility .
2467816	0	Ly-24	100,105	L3T4	0,4	Ly-24	L3T4	12505(Tax:10090)	12504(Tax:10090)	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|nummod|END_ENTITY	L3T4 + T cells promoting susceptibility to murine cutaneous_leishmaniasis express the surface marker Ly-24 -LRB- Pgp-1 -RRB- .
2192903	0	Ly-24	30,35	Pgp-1	23,28	Ly-24	Pgp-1	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of Pgp-1 -LRB- Ly-24 -RRB- by murine peritoneal B lymphocytes .
2784763	0	Ly-24	26,31	Pgp-1	33,38	Ly-24	Pgp-1	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mouse_strain variation in Ly-24 -LRB- Pgp-1 -RRB- expression by peripheral T cells and thymocytes : implications for T cell differentiation .
11342639	0	Ly-49	96,101	T_cell_factor-1	48,63	Ly-49	T cell factor-1	17055(Tax:10090)	21414(Tax:10090)	Gene	Gene	acquisition|nmod|START_ENTITY END_ENTITY|nmod|acquisition	Positive and negative roles of the trans-acting T_cell_factor-1 for the acquisition of distinct Ly-49 MHC class I receptors by NK cells .
11160290	0	Ly-49G	104,110	Ly-49W	0,6	Ly-49G	Ly-49W	16638(Tax:10090)	79410(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Ly-49W , an activating receptor of nonobese diabetic mice with close homology to the inhibitory receptor Ly-49G , recognizes H-2D -LRB- k -RRB- and H-2D -LRB- d -RRB- .
11160290	0	Ly-49W	0,6	Ly-49G	104,110	Ly-49W	Ly-49G	79410(Tax:10090)	16638(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Ly-49W , an activating receptor of nonobese diabetic mice with close homology to the inhibitory receptor Ly-49G , recognizes H-2D -LRB- k -RRB- and H-2D -LRB- d -RRB- .
10807778	0	Ly-6	49,53	Ly-6M	20,25	Ly-6	Ly-6M	17062(Tax:10090)	57248(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Characterization of Ly-6M , a novel member of the Ly-6 family of hematopoietic proteins .
23536638	0	Ly-6C	76,81	CCL2	97,101	Ly-6C	CCL2	17067(Tax:10090)	20296(Tax:10090)	Gene	Gene	monocytes|compound|START_ENTITY monocytes|nmod|END_ENTITY	Circulating fibrocytes prepare the lung for cancer metastasis by recruiting Ly-6C + monocytes via CCL2 .
1717166	0	Ly-6E	40,45	Ly-6E	78,83	Ly-6E	Ly-6E	4061	4061	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Multiple cytokine interactions regulate Ly-6E antigen expression : cooperative Ly-6E induction by IFNs , TNF , and IL-1 in a T_cell_lymphoma and in its induction-deficient variants .
1717166	0	Ly-6E	78,83	Ly-6E	40,45	Ly-6E	Ly-6E	4061	4061	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Multiple cytokine interactions regulate Ly-6E antigen expression : cooperative Ly-6E induction by IFNs , TNF , and IL-1 in a T_cell_lymphoma and in its induction-deficient variants .
20144655	3	Ly-6G	519,524	CD11b	510,515	Ly-6G	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	population|amod|START_ENTITY population|amod|END_ENTITY	Our data demonstrated that CTX actually did mobilize an immunosuppressive myeloid CD11b -LRB- + -RRB- Ly-6G -LRB- - -RRB- population in the NOD mouse spleen in addition to a well-identified neutrophil CD11b -LRB- + -RRB- Ly-6G -LRB- + -RRB- population .
20574007	0	Ly-6G	80,85	CD11b	74,79	Ly-6G	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Tim-3 / galectin-9 pathway : regulation of Th1 immunity through promotion of CD11b + Ly-6G + myeloid cells .
10807778	0	Ly-6M	20,25	Ly-6	49,53	Ly-6M	Ly-6	57248(Tax:10090)	17062(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Characterization of Ly-6M , a novel member of the Ly-6 family of hematopoietic proteins .
23355739	0	Ly108	11,16	promyelocytic_zinc_finger_transcription_factor	37,83	Ly108	promyelocytic zinc finger transcription factor	30925(Tax:10090)	235320(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Ly108 in the induction of promyelocytic_zinc_finger_transcription_factor in developing thymocytes .
3102251	0	Ly24	24,28	Pgp-1	14,19	Ly24	Pgp-1	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of Pgp-1 -LRB- or Ly24 -RRB- by subpopulations of mouse thymocytes and activated peripheral T lymphocytes .
11009081	0	Ly49	27,31	CD4	46,49	Ly49	CD4	17055(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Differential regulation of Ly49 expression on CD4 + and CD4-CD8 - -LRB- double negative -RRB- NK1 .1 + T cells .
25926675	0	Ly49	32,36	Pro1	44,48	Ly49	Pro1	17055(Tax:10090)	19125(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The distal upstream promoter in Ly49 genes , Pro1 , is active in mature NK cells and T cells , does not require TATA boxes , and displays enhancer activity .
8574853	0	Ly49A	12,17	Ly49C	26,31	Ly49A	Ly49C	16627(Tax:10090)	16634(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of Ly49A and 5E6 -LRB- Ly49C -RRB- molecules in hybrid_resistance mediated by murine natural killer cells against normal T cell blasts .
8574853	0	Ly49C	26,31	Ly49A	12,17	Ly49C	Ly49A	16634(Tax:10090)	16627(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of Ly49A and 5E6 -LRB- Ly49C -RRB- molecules in hybrid_resistance mediated by murine natural killer cells against normal T cell blasts .
19726683	0	Ly6	38,41	GPIHBP1	52,59	Ly6	GPIHBP1	17062(Tax:10090)	68453(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein_lipase .
22101863	0	Ly6	17,20	Msq1	30,34	Ly6	Msq1	17062(Tax:10090)	100035637(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1 .
27057101	0	Ly6C	65,69	MIF	0,3	Ly6C	MIF	17067(Tax:10090)	17319(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	MIF Promotes Classical Activation and Conversion of Inflammatory Ly6C -LRB- high -RRB- Monocytes into TipDCs during Murine Toxoplasmosis .
21170045	0	Ly6G	130,134	CD11b	124,129	Ly6G	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Histamine_deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b + Ly6G + immature myeloid cells .
23374140	0	Ly6G	32,36	CD11b	38,43	Ly6G	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	rescues|dobj|START_ENTITY rescues|parataxis|monocyte monocyte|nsubj|blood blood|amod|END_ENTITY	A modified superantigen rescues Ly6G - CD11b + blood monocyte suppressor function and suppresses antigen-specific inflammation in EAE .
24114144	0	Ly6G	21,25	CD11b	13,18	Ly6G	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	Ly6C|amod|START_ENTITY Ly6C|amod|END_ENTITY	Expansion of CD11b -LRB- + -RRB- Ly6G -LRB- + -RRB- Ly6C -LRB- int -RRB- cells driven by medroxyprogesterone_acetate in mice bearing breast_tumors restrains NK cell effector functions .
24711563	0	Ly6G	14,18	CD11b	0,5	Ly6G	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	START_ENTITY|nummod|+ +|compound|END_ENTITY	CD11b + Ly6Chi Ly6G - immature myeloid cells recruited in response to Salmonella_enterica_serovar_Typhimurium infection exhibit protective and immunosuppressive properties .
26942073	0	Ly6G	6,10	CD11b	0,5	Ly6G	CD11b	546644(Tax:10090)	16409(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD11b + Ly6G + cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis .
12242590	0	Ly9	12,15	CD150	47,52	Ly9	CRACC	17085(Tax:10090)	75345(Tax:10090)	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	Mouse novel Ly9 : a new member of the expanding CD150 -LRB- SLAM -RRB- family of leukocyte cell-surface receptors .
17897297	0	LyGDI	22,27	ARHGDIB	29,36	LyGDI	ARHGDIB	397	397	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Loss of expression of LyGDI -LRB- ARHGDIB -RRB- , a rho GDP-dissociation inhibitor , in Hodgkin_lymphoma .
1384316	0	Lyb-2	6,11	CD72	20,24	Lyb-2	CD72	971	971	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	Human Lyb-2 homolog CD72 is a marker for progenitor B-cell_leukemias .
7876545	0	Lyb-2	29,34	CD72	23,27	Lyb-2	CD72	12517(Tax:10090)	12517(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Structure of the mouse CD72 -LRB- Lyb-2 -RRB- gene and its alternatively spliced transcripts .
8757957	0	Lyb8	33,37	CD22	27,31	Lyb8	CD22	12483(Tax:10090)	12483(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of CD22 -LRB- Lyb8 -RRB- on murine B cells .
26210498	0	Lymphocyte-specific_protein_tyrosine_kinase	0,43	CR6-interacting_factor_1	65,89	Lymphocyte-specific protein tyrosine kinase	CR6-interacting factor 1	3932	90480	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- interacts with CR6-interacting_factor_1 -LRB- CRIF1 -RRB- in mitochondria to repress oxidative phosphorylation .
26210498	0	Lymphocyte-specific_protein_tyrosine_kinase	0,43	CR6-interacting_factor_1	65,89	Lymphocyte-specific protein tyrosine kinase	CR6-interacting factor 1	3932	90480	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- interacts with CR6-interacting_factor_1 -LRB- CRIF1 -RRB- in mitochondria to repress oxidative phosphorylation .
9647260	0	Lymphocyte_activation_gene-3	0,28	LAG-3	30,35	Lymphocyte activation gene-3	LAG-3	3902	3902	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lymphocyte_activation_gene-3 -LRB- LAG-3 -RRB- expression and IFN-gamma production are variably coregulated in different human T lymphocyte subpopulations .
10072520	0	Lymphocyte_activation_gene-3	0,28	TNF-alpha	95,104	Lymphocyte activation gene-3	TNF-alpha	3902	7124	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Lymphocyte_activation_gene-3 , a MHC class II ligand expressed on activated T cells , stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells .
3134364	0	Lymphocyte_function-associated_antigen-1	0,40	intercellular_adhesion_molecule-1	66,99	Lymphocyte function-associated antigen-1	intercellular adhesion molecule-1	3683	3383	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- interaction with intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells .
24658583	0	Lymphoid_Enhancer-Binding_Factor_1	18,52	LEF1	54,58	Lymphoid Enhancer-Binding Factor 1	LEF1	51176	51176	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Lymphoid_Enhancer-Binding_Factor_1 -LRB- LEF1 -RRB- in solid-pseudopapillary_neoplasms of the pancreas .
25178368	0	Lymphoid_Enhancer_Binding_Factor_1	38,72	LEF-1	74,79	Lymphoid Enhancer Binding Factor 1	LEF-1	100170126(Tax:9823)	100170126(Tax:9823)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of Novel Polymorphisms in Lymphoid_Enhancer_Binding_Factor_1 -LRB- LEF-1 -RRB- Gene with Number of Teats in Different Breeds of Pig .
1716614	0	Lymphokine	0,10	CD4	53,56	Lymphokine	CD4	3558	920	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Lymphokine secretion and cytotoxic activity of human CD4 + T-cell clones against Bordetella_pertussis .
8244777	0	Lymphokine	0,10	CD8	37,40	Lymphokine	CD8	3558	925	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Lymphokine gene transcription in CD4 + CD8 - T cells of a type_III_bare_lymphocyte_syndrome patient .
6978826	0	Lymphokine	0,10	interleukin-2	12,25	Lymphokine	interleukin-2	3558	3558	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Lymphokine -LRB- interleukin-2 -RRB- production by mitogen-stimulated human lymphocytes in small reactors .
20473944	0	Lymphotoxin-b_receptor	0,22	lymphotoxin-a	37,50	Lymphotoxin-b receptor	lymphotoxin-a	17000(Tax:10090)	16992(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Lymphotoxin-b_receptor activation by lymphotoxin-a -LRB- 1 -RRB- b -LRB- 2 -RRB- and LIGHT promotes tumor growth in an NFkB-dependent manner .
7916655	0	Lymphotoxin_beta	0,16	TNF	40,43	Lymphotoxin beta	TNF	4050	7124	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Lymphotoxin_beta , a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface .
12169272	0	Lymphotoxin_beta_receptor	0,25	interleukin_8	34,47	Lymphotoxin beta receptor	interleukin 8	4055	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Lymphotoxin_beta_receptor induces interleukin_8 gene expression via NF-kappaB and AP-1 activation .
16621960	0	Lyn	15,18	CCR5	35,39	Lyn	CCR5	4067	1234	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The Src kinase Lyn is required for CCR5 signaling in response to MIP-1beta and R5 HIV-1_gp120 in human macrophages .
7545683	0	Lyn	66,69	CD20	109,113	Lyn	CD20	4067	54474	Gene	Gene	kinases|dobj|START_ENTITY kinases|nmod|END_ENTITY	Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn , Fyn , and Lck with the B cell molecule CD20 .
12393728	0	Lyn	139,142	CD45	0,4	Lyn	CD45	17096(Tax:10090)	19264(Tax:10090)	Gene	Gene	inactivation|nmod|START_ENTITY associated|nmod|inactivation cells|acl|associated differentiation|nmod|cells inhibits|dobj|differentiation inhibits|nsubj|phosphatase phosphatase|nummod|END_ENTITY	CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34 + cells associated with selective inactivation of Lyn .
7499277	0	Lyn	24,27	CD45	47,51	Lyn	CD45	4067	5788	Gene	Gene	regulation|nmod|START_ENTITY tyrosine|nsubj|regulation tyrosine|xcomp|kinase kinase|nmod|END_ENTITY	Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells .
22731636	0	Lyn	0,3	ERK1/2	32,38	Lyn	ERK1/2	4067	5595;5594	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|activation activation|compound|END_ENTITY	Lyn is involved in CD24-induced ERK1/2 activation in colorectal_cancer .
10643150	0	Lyn	26,29	G-CSFR	110,116	Lyn	G-CSFR	4067	1441	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte_colony-stimulating_factor receptor -LRB- G-CSFR -RRB- is not abrogated in neutrophils from severe congenital_neutropenia patients with point mutations in the G-CSFR mRNA .
21636860	0	Lyn	44,47	G-CSF_receptor	0,14	Lyn	G-CSF receptor	17096(Tax:10090)	12986(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	G-CSF_receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase .
10713104	0	Lyn	19,22	HS1	0,3	Lyn	HS1	4067	3059	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells .
22768161	0	Lyn	7,10	HS1	0,3	Lyn	HS1	4067	3059	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	HS1 , a Lyn kinase substrate , is abnormally expressed in B-chronic_lymphocytic_leukemia and correlates with response to fludarabine-based regimen .
23450709	0	Lyn	116,119	MicroRNA-30a	0,12	Lyn	MicroRNA-30a	4067	407029	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|nsubj|END_ENTITY	MicroRNA-30a promotes B cell hyperactivity in patients with systemic_lupus_erythematosus by direct interaction with Lyn .
20564182	0	Lyn	58,61	PTPROt	78,84	Lyn	PTPROt	4067	5800	Gene	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	Lyn kinase and ZAP70 are substrates of PTPROt in B-cells : Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib .
20944008	0	Lyn	19,22	PTPalpha	0,8	Lyn	PTPalpha	17096(Tax:10090)	19262(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses .
12374219	0	Lyn	65,68	TAG-1	36,41	Lyn	TAG-1	81515(Tax:10116)	25356(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of GPI-anchored protein TAG-1 with src-family kinase Lyn in lipid rafts of cerebellar granule cells .
9452436	0	Lyn	26,29	granulocyte_colony-stimulating_factor	64,101	Lyn	granulocyte colony-stimulating factor	421127(Tax:9031)	1440	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte_colony-stimulating_factor .
12586738	0	Lyn	44,47	p54	4,7	Lyn	p54	4067	3433	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis .
8734569	0	Lyp	107,110	IDDM1	80,85	Lyp	IDDM1	326380(Tax:10116)	326381(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	T cells from BB-DP rats show a unique cytokine mRNA profile associated with the IDDM1 susceptibility gene , Lyp .
22920283	0	Lysine-specific_demethylase_1	29,58	LSD1	23,27	Lysine-specific demethylase 1	LSD1	23028	23028	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of LSD1 -LRB- Lysine-specific_demethylase_1 -RRB- during tumour progression from pre-invasive to invasive ductal_carcinoma_of_the_breast .
24687155	0	Lysine_Specific_Demethylase_1	48,77	LSD1	79,83	Lysine Specific Demethylase 1	LSD1	23028	23028	Gene	Gene	Assay|nmod|START_ENTITY Assay|appos|END_ENTITY	Heterogeneous Antibody-Based Activity Assay for Lysine_Specific_Demethylase_1 -LRB- LSD1 -RRB- on a Histone Peptide Substrate .
26126825	0	Lysosomal-Associated_Transmembrane_Protein_4B	0,45	TGF-b1	66,72	Lysosomal-Associated Transmembrane Protein 4B	TGF-b1	55353	7040	Gene	Gene	Decreases|nsubj|START_ENTITY Decreases|dobj|Production Production|compound|END_ENTITY	Lysosomal-Associated_Transmembrane_Protein_4B -LRB- LAPTM4B -RRB- Decreases TGF-b1 Production in Human Regulatory T Cells .
9478926	0	Lysosomal_integral_membrane_protein_II	0,38	thrombospondin-1	45,61	Lysosomal integral membrane protein II	thrombospondin-1	950	7057	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Lysosomal_integral_membrane_protein_II binds thrombospondin-1 .
25998573	0	Lysosome-Associated_Protein_Transmembrane_5	32,75	LAPTM5	77,83	Lysosome-Associated Protein Transmembrane 5	LAPTM5	16792(Tax:10090)	7805	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and Polymorphisms of Lysosome-Associated_Protein_Transmembrane_5 -LRB- LAPTM5 -RRB- in Patients with Systemic_Lupus_Erythematosus in a Chinese Population .
25899805	0	Lysozyme	29,37	HMGB1	46,51	Lysozyme	HMGB1	4069	3146	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Anti-Inflammatory Effects of Lysozyme Against HMGB1 in Human Endothelial Cells and in Mice .
8618042	0	Lysozyme	0,8	elastin	18,25	Lysozyme	elastin	4069	2006	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Lysozyme binds to elastin and protects elastin from elastase-mediated degradation .
2669620	0	Lysozyme	0,8	lysozyme	39,47	Lysozyme	lysozyme	4069	4069	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Lysozyme and cancer : role of exogenous lysozyme as anticancer agent -LRB- review -RRB- .
7442124	0	Lysozyme	0,8	lysozyme	102,110	Lysozyme	lysozyme	100340903(Tax:9986)	100340903(Tax:9986)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Lysozyme activity in gastrointestinal and lymphoreticular tissues of rabbits_genetically_deficient in lysozyme .
27029493	0	Lysyl_Oxidase	0,13	SNAI2	48,53	Lysyl Oxidase	SNAI2	4015	6591	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Lysyl_Oxidase -LRB- LOX -RRB- transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers .
18566459	0	Lysyl_oxidase	0,13	LOX	61,64	Lysyl oxidase	LOX	4015	4015	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Lysyl_oxidase activity in the ocular tissues and the role of LOX in proliferative_diabetic_retinopathy and rhegmatogenous_retinal_detachment .
23190333	0	Lysyl_oxidase	27,40	LOX	42,45	Lysyl oxidase	LOX	16948(Tax:10090)	16948(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression and role of Lysyl_oxidase -LRB- LOX -RRB- in dentinogenesis .
24502826	0	Lysyl_oxidase	15,28	LOX	30,33	Lysyl oxidase	LOX	4015	4015	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of Lysyl_oxidase -LRB- LOX -RRB- polymorphisms with the risk of Keratoconus in an Iranian population .
25759215	0	Lysyl_oxidase-like_2	0,20	Notch1	31,37	Lysyl oxidase-like 2	Notch1	94352(Tax:10090)	18128(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Lysyl_oxidase-like_2 represses Notch1 expression in the skin to promote squamous_cell_carcinoma progression .
2879623	0	Lyt-1	95,100	L3T4	89,93	Lyt-1	L3T4	12507(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Induction of `` innocent bystander '' cytotoxicity in nonimmune mice by adoptive transfer of L3T4 + Lyt-1 +2 - mammary tumor immune T-cells .
2858391	0	Lyt-1	80,85	Lyt-2	87,92	Lyt-1	Lyt-2	12507(Tax:10090)	12525(Tax:10090)	Gene	Gene	Relationship|amod|START_ENTITY granulated|nsubj|Relationship granulated|parataxis|+ +|nsubj|END_ENTITY	Murine intestinal intraepithelial lymphocytes I. Relationship of a novel Thy-1 - , Lyt-1 - , Lyt-2 + , granulated subpopulation to natural killer cells and mast cells .
6217978	0	Lyt-1	102,107	Lyt-2	108,113	Lyt-1	Lyt-2	12507(Tax:10090)	12525(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Suppression of cell-mediated lymphocytotoxicity against minor histocompatibility antigens mediated by Lyt-1 + Lyt-2 + T cells of stimulator-strain origin .
2879865	1	Lyt-1	143,148	Thy-1	137,142	Lyt-1	Thy-1	12507(Tax:10090)	21838(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	I. Induction of a nylon-adherent , Thy-1 + Lyt-1 +2 - suppressor cell .
2888223	1	Lyt-1	75,80	Thy-1	68,73	Lyt-1	Thy-1	12507(Tax:10090)	21838(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Destruction of a Thy-1 + Lyt-1 +2 - spleen cell implicated in the expression of hybrid resistance .
2942460	1	Lyt-2	215,220	L3T4	209,213	Lyt-2	L3T4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod:npmod|+ +|nummod|END_ENTITY	The expression of L3T4 and Lyt-2 cell surface molecules separates T cells into two broad , non-overlapping subsets : typical T helper cells are L3T4 + Lyt-2 - whereas most T killer cells and their precursors are L3T4 - Lyt-2 + .
2858391	0	Lyt-2	87,92	Lyt-1	80,85	Lyt-2	Lyt-1	12525(Tax:10090)	12507(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY granulated|parataxis|+ granulated|nsubj|Relationship Relationship|amod|END_ENTITY	Murine intestinal intraepithelial lymphocytes I. Relationship of a novel Thy-1 - , Lyt-1 - , Lyt-2 + , granulated subpopulation to natural killer cells and mast cells .
6217978	0	Lyt-2	108,113	Lyt-1	102,107	Lyt-2	Lyt-1	12525(Tax:10090)	12507(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Suppression of cell-mediated lymphocytotoxicity against minor histocompatibility antigens mediated by Lyt-1 + Lyt-2 + T cells of stimulator-strain origin .
3085100	0	Lyt-2	15,20	Lyt-2	63,68	Lyt-2	Lyt-2	12525(Tax:10090)	12525(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Involvement of Lyt-2 and L3T4 in activation of hapten-specific Lyt-2 + L3T4 + T-cell clones .
3085100	0	Lyt-2	63,68	Lyt-2	15,20	Lyt-2	Lyt-2	12525(Tax:10090)	12525(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Involvement of Lyt-2 and L3T4 in activation of hapten-specific Lyt-2 + L3T4 + T-cell clones .
3487583	0	Lyt-2	45,50	T_cell_differentiation_antigen	51,81	Lyt-2	T cell differentiation antigen	12525(Tax:10090)	21939(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Structure , sequence , and polymorphism of the Lyt-2 T_cell_differentiation_antigen gene .
3116095	0	Lyt-2	63,68	c-myb	33,38	Lyt-2	c-myb	12525(Tax:10090)	17863(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	The expression and regulation of c-myb transcription in B6/lpr Lyt-2 - , L3T4-T lymphocytes .
3096774	5	Lyt1	1107,1111	Lyt2	1113,1117	Lyt1	Lyt2	12507(Tax:10090)	12525(Tax:10090)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	In M , two significant peaks were found in Lyt1 + / Lyt2 + cell ratio .
2602913	0	Lyt2	59,63	L3T4	65,69	Lyt2	L3T4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	-|amod|START_ENTITY -|compound|END_ENTITY	Cyclosporine_A prevents the generation of single positive -LRB- Lyt2 + L3T4 - , Lyt2 - L3T4 + -RRB- mature T cells , but not single positive -LRB- Lyt2 + T3 - -RRB- Immature thymocytes , in newborn mice .
2602913	0	Lyt2	72,76	L3T4	65,69	Lyt2	L3T4	12525(Tax:10090)	12504(Tax:10090)	Gene	Gene	-|dep|START_ENTITY -|compound|END_ENTITY	Cyclosporine_A prevents the generation of single positive -LRB- Lyt2 + L3T4 - , Lyt2 - L3T4 + -RRB- mature T cells , but not single positive -LRB- Lyt2 + T3 - -RRB- Immature thymocytes , in newborn mice .
3096774	5	Lyt2	1113,1117	Lyt1	1107,1111	Lyt2	Lyt1	12525(Tax:10090)	12507(Tax:10090)	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	In M , two significant peaks were found in Lyt1 + / Lyt2 + cell ratio .
3093094	0	Lyt_1	77,82	MHC_class_I_antigen	22,41	Lyt 1	MHC class I antigen	12507(Tax:10090)	547348(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	402AX teratocarcinoma MHC_class_I_antigen expression is regulated in vivo by Lyt_1 , Lyt_2 , and L3T4 expressing splenic T cells .
25508922	0	M-CSF	34,39	ABCA1	1,6	M-CSF	ABCA1	1435	19	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	-LSB- ABCA1 mRNA and protein levels IN M-CSF macrophages from patients with arterial_stenosis -RSB- .
7858491	0	M-CSF	54,59	C-FMS	70,75	M-CSF	C-FMS	1435	1436	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression and genomic configuration of GM-CSF , IL-3 , M-CSF receptor -LRB- C-FMS -RRB- , early_growth_response_gene-1 _ -LRB- EGR-1 -RRB- and M-CSF genes in primary myelodysplastic_syndromes .
8305020	0	M-CSF	44,49	C-fms	0,5	M-CSF	C-fms	1435	1436	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	C-fms expression in B-cells and response to M-CSF .
19008293	0	M-CSF	27,32	C-reactive_protein	0,18	M-CSF	C-reactive protein	1435	1401	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	C-reactive_protein induces M-CSF release and macrophage proliferation .
3105621	0	M-CSF	18,23	CSF-1	25,30	M-CSF	CSF-1	1435	1435	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the M-CSF -LRB- CSF-1 -RRB- gene by human monocytes .
10897214	0	M-CSF	98,103	G-CSF	148,153	M-CSF	G-CSF	1435	1440	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	-LSB- In vitro growth and clinical response of leukemia cells to macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in acute_leukemia -RSB- .
1492809	0	M-CSF	48,53	G-CSF	98,103	M-CSF	G-CSF	1435	1440	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	Origin of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in amniotic fluid .
16685390	0	M-CSF	13,18	G-CSF	0,5	M-CSF	G-CSF	12977(Tax:10090)	12985(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|and/or and/or|compound|END_ENTITY	G-CSF and/or M-CSF accelerate differentiation of bone marrow cells into endothelial progenitor cells in vitro .
17243911	0	M-CSF	104,109	G-CSF	55,60	M-CSF	G-CSF	1435	1440	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	Serum levels of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and macrophage colony-stimulating factor -LRB- M-CSF -RRB- in pancreatic_cancer patients .
1370208	0	M-CSF	89,94	GM-CSF	48,54	M-CSF	GM-CSF	1435	1437	Gene	Gene	not|nmod|START_ENTITY downregulate|dep|not downregulate|dobj|expression expression|nmod|END_ENTITY	Glucocorticoids downregulate gene expression of GM-CSF , NAP-1 / IL-8 , and IL-6 , but not of M-CSF in human fibroblasts .
15358207	0	M-CSF	29,34	GM-CSF	0,6	M-CSF	GM-CSF	1435	1437	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	GM-CSF can not substitute for M-CSF in human osteoclastogenesis .
1623556	0	M-CSF	52,57	GM-CSF	109,115	M-CSF	GM-CSF	1435	1437	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY Production|nmod|macrophage_colony-stimulating_factor regulated|nsubjpass|Production regulated|nmod|END_ENTITY	Production of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- by human monocytes is differentially regulated by GM-CSF , TNF_alpha , and IFN-gamma .
1701692	0	M-CSF	18,23	GM-CSF	96,102	M-CSF	GM-CSF	12977(Tax:10090)	12981(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor controlled|nsubjpass|Expression controlled|nmod|actions actions|nmod|END_ENTITY	Expression of the M-CSF receptor is controlled posttranscriptionally by the dominant actions of GM-CSF or multi-CSF .
25202910	0	M-CSF	72,77	GM-CSF	0,6	M-CSF	GM-CSF	12977(Tax:10090)	12981(Tax:10090)	Gene	Gene	macrophages|amod|START_ENTITY similar|nmod|macrophages improve|xcomp|similar treated|ccomp|improve treated|nsubj|END_ENTITY	GM-CSF treated F4/80 + BMCs improve murine hind_limb_ischemia similar to M-CSF differentiated macrophages .
7858491	0	M-CSF	54,59	GM-CSF	40,46	M-CSF	GM-CSF	1435	1437	Gene	Gene	receptor|amod|START_ENTITY configuration|appos|receptor configuration|nmod|END_ENTITY	Expression and genomic configuration of GM-CSF , IL-3 , M-CSF receptor -LRB- C-FMS -RRB- , early_growth_response_gene-1 _ -LRB- EGR-1 -RRB- and M-CSF genes in primary myelodysplastic_syndromes .
7884321	0	M-CSF	116,121	GM-CSF	177,183	M-CSF	GM-CSF	1435	1437	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	Differential regulation of fyn-associated protein tyrosine kinase activity by macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
17022947	0	M-CSF	44,49	Hepatocyte_growth_factor	0,24	M-CSF	Hepatocyte growth factor	1435	3082	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	Hepatocyte_growth_factor can substitute for M-CSF to support osteoclastogenesis .
24748497	0	M-CSF	0,5	IL-32	38,43	M-CSF	IL-32	1435	9235	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	M-CSF inhibits anti-HIV-1 activity of IL-32 , but they enhance M2-like phenotypes of macrophages .
8726670	0	M-CSF	157,162	IL-4	97,101	M-CSF	IL-4	1435	3565	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Leukaemia_inhibitory_factor -LRB- LIF -RRB- production in pleural_effusions : comparison with production of IL-4 , IL-8 , IL-10 and macrophage-colony_stimulating_factor -LRB- M-CSF -RRB- .
1382099	4	M-CSF	762,767	IL-6	750,754	M-CSF	IL-6	1435	3569	Gene	Gene	G-CSF|dep|START_ENTITY G-CSF|compound|END_ENTITY	On exposure of human astrocytes to IL-1_beta , high levels of IL-6 , IL-8 , M-CSF , G-CSF , and GM-CSF mRNAs were detected ; moreover , active secretion of all the above cytokines was demonstrated .
15325277	0	M-CSF	35,40	Interleukin-10	0,14	M-CSF	Interleukin-10	1435	3586	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interleukin-10 in combination with M-CSF and IL-4 contributes to development of the rare population of CD14 + CD16 + + cells derived from human monocytes .
1883525	0	M-CSF	14,19	M-CSF	34,39	M-CSF	M-CSF	1435	1435	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of M-CSF expression by M-CSF : role of protein_kinase_C and transcription factor NF_kappa_B .
1883525	0	M-CSF	34,39	M-CSF	14,19	M-CSF	M-CSF	1435	1435	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of M-CSF expression by M-CSF : role of protein_kinase_C and transcription factor NF_kappa_B .
9158105	0	M-CSF	55,60	MIF	95,98	M-CSF	MIF	78965(Tax:10116)	81683(Tax:10116)	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	Up-regulation of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and migration_inhibitory_factor -LRB- MIF -RRB- expression and monocyte recruitment during lipid-induced glomerular_injury in the exogenous hypercholesterolaemic -LRB- ExHC -RRB- rat .
7634342	0	M-CSF	38,43	Macrophage_colony-stimulating_factor	0,36	M-CSF	Macrophage colony-stimulating factor	1435	1435	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- induction of enhanced anticryptococcal activity in human monocyte-derived macrophages : synergy with fluconazole for killing .
1883525	0	M-CSF	14,19	NF_kappa_B	91,101	M-CSF	NF kappa B	1435	4790	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of M-CSF expression by M-CSF : role of protein_kinase_C and transcription factor NF_kappa_B .
18839612	0	M-CSF	110,115	SCF	63,66	M-CSF	SCF	1435	4254	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	-LSB- The plasma levels and diagnostic utility of stem_cell_factor -LRB- SCF -RRB- and macrophage-colony_stimulating_factor -LRB- M-CSF -RRB- in cervical_cancer patients -RSB- .
15840777	0	M-CSF	138,143	VEGF	90,94	M-CSF	VEGF	12977(Tax:10090)	22339(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Effects of cyclic tensile forces on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and macrophage-colony-stimulating_factor -LRB- M-CSF -RRB- in murine osteoblastic MC3T3-E1 cells .
18852899	0	M-CSF	0,5	VEGF	61,65	M-CSF	VEGF	1435	7422	Gene	Gene	signals|nsubj|START_ENTITY signals|xcomp|induce induce|dobj|production production|amod|END_ENTITY	M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo .
22906984	0	M-CSF	51,56	VEGF	0,4	M-CSF	VEGF	1435	7422	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	VEGF , FLT3_ligand , PlGF and HGF can substitute for M-CSF to induce human osteoclast formation : implications for giant_cell_tumour pathobiology .
17420256	0	M-CSF	0,5	c-Fms	86,91	M-CSF	c-Fms	1435	1436	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|cytoskeleton cytoskeleton|nmod|recruitment recruitment|nmod|697/721 697/721|amod|multimeric multimeric|dep|signaling signaling|xcomp|complex complex|nmod|Tyr-559 Tyr-559|amod|END_ENTITY	M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559 / 697/721 .
19705931	0	M-CSF	3,8	c-Fms	18,23	M-CSF	c-Fms	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	antibody|amod|START_ENTITY antibody|compound|END_ENTITY	An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice .
9852586	0	M-CSF	69,74	c-fms	48,53	M-CSF	c-fms	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells .
20604722	0	M-CSF	69,74	macrophage-colony_stimulating_factor	31,67	M-CSF	macrophage-colony stimulating factor	1435	1435	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of serum macrophage-colony_stimulating_factor -LRB- M-CSF -RRB- in esophageal_cancer patients and its comparison with classical tumor markers .
10632665	0	M-CSF	49,54	macrophage_colony-stimulating_factor	11,47	M-CSF	macrophage colony-stimulating factor	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on anti-fungal activity of mononuclear phagocytes against Trichosporon asahii .
10926834	0	M-CSF	79,84	macrophage_colony-stimulating_factor	41,77	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	cAMP attenuates interleukin-1-stimulated macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- expression .
1581229	0	M-CSF	73,78	macrophage_colony-stimulating_factor	35,71	M-CSF	macrophage colony-stimulating factor	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Epidermal_growth_factor stimulates macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- mRNA expression and M-CSF release in cultured murine stromal cells .
17880962	0	M-CSF	53,58	macrophage_colony-stimulating_factor	15,51	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- in the function of follicular granulosa cells .
1838015	0	M-CSF	52,57	macrophage_colony-stimulating_factor	14,50	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- in two Hodgkin 's Reed-Sternberg -LRB- H-RS -RRB- cell lines , HDLM-1 and KM-H2 , and in H-RS cells in tissues .
8107489	0	M-CSF	68,73	macrophage_colony-stimulating_factor	30,66	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Basal expression of the human macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- gene in K562 cells .
8199046	0	M-CSF	44,49	macrophage_colony-stimulating_factor	6,42	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL .
8347686	0	M-CSF	52,57	macrophage_colony-stimulating_factor	14,50	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- by human articular cartilage and chondrocytes .
8573750	0	M-CSF	52,57	macrophage_colony-stimulating_factor	14,50	M-CSF	macrophage colony-stimulating factor	78965(Tax:10116)	78965(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on the progression of lipid-induced nephrotoxicity in diabetic_nephropathy .
8929623	0	M-CSF	138,143	macrophage_colony-stimulating_factor	100,136	M-CSF	macrophage colony-stimulating factor	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Neonatal changes of osteoclasts in osteopetrosis -LRB- op/op -RRB- mice defective in production of functional macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- protein and effects of M-CSF on osteoclast development and differentiation .
9543701	0	M-CSF	48,53	macrophage_colony-stimulating_factor	10,46	M-CSF	macrophage colony-stimulating factor	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on mouse immune responses in vivo .
9629620	0	M-CSF	92,97	macrophage_colony-stimulating_factor	54,90	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Exposure-based safety evaluation of recombinant human macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- in cynomolgus_monkeys .
9698485	0	M-CSF	44,49	macrophage_colony-stimulating_factor	6,42	M-CSF	macrophage colony-stimulating factor	1435	1435	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- levels in patients with epithelial_ovarian_cancer .
7814798	0	M-CSF	54,59	macrophage_colony_stimulating_factor	16,52	M-CSF	macrophage colony stimulating factor	1435	1435	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of macrophage_colony_stimulating_factor -LRB- M-CSF -RRB- in liver_disease .
7720833	0	M-CSF	58,63	monocyte-macrophage_colony-stimulating_factor	11,56	M-CSF	monocyte-macrophage colony-stimulating factor	1435	1435	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of monocyte-macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on in vitro erythropoiesis of marrow progenitor cells from patients with renal_anemia .
25007875	0	M-CSF	83,88	p38_MAPK	104,112	M-CSF	p38 MAPK	12977(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Rho-kinase regulation of TNF-a-induced nuclear translocation of NF-kB RelA/p65 and M-CSF expression via p38_MAPK in mesangial cells .
12928417	0	M-CSF	0,5	vascular_endothelial_growth_factor	14,48	M-CSF	vascular endothelial growth factor	1435	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	M-CSF induces vascular_endothelial_growth_factor production and angiogenic activity from human monocytes .
1385639	0	M-CSF_and_its_receptor	14,36	C-FMS	38,43	M-CSF and its receptor	C-FMS	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of M-CSF_and_its_receptor -LRB- C-FMS -RRB- during factor-independent cell line evolution from hematopoietic progenitor cells cocultivated with gamma irradiated marrow stromal cell lines .
12138204	0	M-Ras	7,12	R-Ras3	0,6	M-Ras	R-Ras3	25482(Tax:10116)	22808	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	R-Ras3 / M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade .
22121046	0	M-Ras	0,5	Ral	14,17	M-Ras	Ral	22808	5898	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast_cancer cells .
16923128	0	M-Ras	24,29	nerve_growth_factor	41,60	M-Ras	nerve growth factor	25482(Tax:10116)	310738(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Sustained activation of M-Ras induced by nerve_growth_factor is essential for neuronal differentiation of PC12 cells .
10498616	0	M-Ras	0,5	p21_Ras	45,52	M-Ras	p21 Ras	22808	3265	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	M-Ras , a widely expressed 29-kD homologue of p21_Ras : expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line .
22114306	0	M-cadherin	36,46	GSK-3b	15,21	M-cadherin	GSK-3b	12555(Tax:10090)	56637(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Suppression of GSK-3b activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation .
7853543	0	M1	48,50	matrix_protein	32,46	M1	matrix protein	100507027	100507027	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Nucleus-targeting domain of the matrix_protein -LRB- M1 -RRB- of influenza virus .
15703380	0	M1	75,77	mu_opioid_receptor	36,54	M1	mu opioid receptor	12669(Tax:10090)	18390(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of mouse mu_opioid_receptor gene : Sp3 isoforms -LRB- M1 , M2 -RRB- function as repressors in neuronal cells to regulate the mu_opioid_receptor gene .
21911481	0	M18BP1	16,22	CENP-C	0,6	M18BP1	CENP-C	55320	1060	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly .
12500666	0	M1_and_P1	46,55	glutathione_S-transferase_T1	16,44	M1 and P1	glutathione S-transferase T1	100507027	2952	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Polymorphism of glutathione_S-transferase_T1 , M1_and_P1 genes in a Shanghai population : patients with occupational or non-occupational_bladder_cancer .
10516442	0	M31	0,3	HP1	36,39	M31	HP1	110831(Tax:10090)	31834(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	M31 , a murine homolog of Drosophila HP1 , is concentrated in the XY body during spermatogenesis .
8751383	0	M32	0,3	heterochromatin_protein_1	38,63	M32	heterochromatin protein 1	12417(Tax:10090)	34119(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	M32 , a murine homologue of Drosophila heterochromatin_protein_1 -LRB- HP1 -RRB- , localises to euchromatin within interphase nuclei and is largely excluded from constitutive heterochromatin .
10373480	0	M3_muscarinic_acetylcholine_receptors	0,37	myosin	59,65	M3 muscarinic acetylcholine receptors	myosin	1131	79784	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	M3_muscarinic_acetylcholine_receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein_kinase_C isoforms .
18581270	0	M6B	22,25	serotonin_transporter	51,72	M6B	serotonin transporter	2824	6532	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Membrane glycoprotein M6B interacts with the human serotonin_transporter .
25884643	0	MACC1	67,72	Metastasis_Associated_in_Colon_Cancer_1	26,65	MACC1	Metastasis Associated in Colon Cancer 1	346389	346389	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Heterogeneity analysis of Metastasis_Associated_in_Colon_Cancer_1 -LRB- MACC1 -RRB- for survival prognosis of colorectal_cancer patients : a retrospective cohort study .
24568531	0	MACC1	0,5	PFKFB2	33,39	MACC1	PFKFB2	346389	5208	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	MACC1 expression correlates with PFKFB2 and survival_in_hepatocellular_carcinoma .
23291068	0	MACC1	82,87	metastasis-associated_in_colon_cancer_1	41,80	MACC1	metastasis-associated in colon cancer 1	346389	346389	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression and clinical significance of metastasis-associated_in_colon_cancer_1 -LRB- MACC1 -RRB- in HBV-related_hepatocellular_carcinoma -RSB- .
25579553	0	MACC1	68,73	metastasis_associated_in_colon_cancer_1	27,66	MACC1	metastasis associated in colon cancer 1	346389	346389	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of metastasis_associated_in_colon_cancer_1 -LRB- MACC1 -RRB- expression in patients with gallbladder_cancer .
16815997	0	MACF1	54,59	microtubule_actin_cross-linking_factor_1	12,52	MACF1	microtubule actin cross-linking factor 1	11426(Tax:10090)	11426(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of microtubule_actin_cross-linking_factor_1 -LRB- MACF1 -RRB- in the Wnt signaling pathway .
1860846	0	MACS	71,75	MARCKS	57,63	MACS	MARCKS	4082	4082	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- gene -LRB- MACS -RRB- .
1860846	0	MACS	71,75	myristoylated_alanine-rich_C_kinase_substrate	10,55	MACS	myristoylated alanine-rich C kinase substrate	4082	4082	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- gene -LRB- MACS -RRB- .
7532282	0	MAD-3	151,156	I_kappa_B_alpha	135,150	MAD-3	I kappa B alpha	4792	4792	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Transcription-independent turnover of I_kappa_B_alpha during monocyte adherence : implications for a translational component regulating I_kappa_B_alpha / MAD-3 mRNA levels .
22024768	0	MAD1	31,35	E-cadherin	64,74	MAD1	E-cadherin	8379	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The spindle checkpoint protein MAD1 regulates the expression of E-cadherin and prevents cell migration .
18203738	0	MAD1	18,22	G-CSF	35,40	MAD1	G-CSF	8379	1440	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the MAD1 promoter by G-CSF .
26698869	0	MAD1	23,27	TCP10L	0,6	MAD1	TCP10L	4084	140290	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction .
21345218	0	MAD1	15,19	TGFb1	0,5	MAD1	TGFb1	4084	7040	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TGFb1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation : basic functions of C/EBP , SP and SMAD3 transcription factors .
20870947	0	MAD2	68,72	Pcid2	17,22	MAD2	Pcid2	56150(Tax:10090)	234069(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression role|nmod|regulation role|nmod|END_ENTITY	Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression .
25232865	0	MAD2	19,23	WT1	0,3	MAD2	WT1	4085	7490	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	WT1 interacts with MAD2 and regulates mitotic checkpoint function .
21335556	0	MAD2	79,83	mitotic_arrest_deficient_2	51,77	MAD2	mitotic arrest deficient 2	4085	4085	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Orderly inactivation of the key checkpoint protein mitotic_arrest_deficient_2 -LRB- MAD2 -RRB- during mitotic progression .
19753112	0	MAD2B	37,42	RAN	75,78	MAD2B	RAN	10459	5901	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The mitotic_arrest_deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle .
21152103	0	MAD2B	37,42	clathrin_light_chain_A	62,84	MAD2B	clathrin light chain A	10459	1211	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The mitotic_arrest_deficient protein MAD2B interacts with the clathrin_light_chain_A during mitosis .
10527948	0	MAD2beta	229,237	MDC9	189,193	MAD2beta	MDC9	10459	8754	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Evidence for an interaction of the metalloprotease-disintegrin tumour_necrosis_factor_alpha_convertase -LRB- TACE -RRB- with mitotic_arrest_deficient_2 -LRB- MAD2 -RRB- , and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein , MAD2beta .
8262046	0	MAD3	59,63	I_kappa_B-alpha	43,58	MAD3	I kappa B-alpha	4792	4792	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Promoter analysis of the gene encoding the I_kappa_B-alpha / MAD3 inhibitor of NF-kappa_B : positive regulation by members of the rel/NF-kappa _ B family .
8505309	0	MAD3	46,50	NF-kappa_B	87,97	MAD3	NF-kappa B	4792	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|proteins proteins|compound|END_ENTITY	Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa_B proteins in human monocytic THP-1 cells .
15469726	0	MAD4	60,64	TCP10L	44,50	MAD4	TCP10L	10608	140290	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human liver specific transcriptional factor TCP10L binds to MAD4 .
24038283	0	MADD	0,4	PTEN	31,35	MADD	PTEN	8567	5728	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MADD is a downstream target of PTEN in triggering apoptosis .
20627078	0	MADD-2	0,6	MID1	48,52	MADD-2	MID1	178619(Tax:6239)	4281	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	MADD-2 , a homolog of the Opitz_syndrome protein MID1 , regulates guidance to the midline through UNC-40 in Caenorhabditis_elegans .
20627077	0	MADD-2	29,35	UNC-40	64,70	MADD-2	UNC-40	178619(Tax:6239)	172233(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY motif|dobj|functions motif|nmod|END_ENTITY	The tripartite motif protein MADD-2 functions with the receptor UNC-40 -LRB- DCC -RRB- in Netrin-mediated axon attraction and branching .
20627078	0	MADD-2	0,6	UNC-40	96,102	MADD-2	UNC-40	178619(Tax:6239)	172233(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MADD-2 , a homolog of the Opitz_syndrome protein MID1 , regulates guidance to the midline through UNC-40 in Caenorhabditis_elegans .
8694785	0	MADM	21,25	mammalian_disintegrin-metalloprotease	50,87	MADM	mammalian disintegrin-metalloprotease	29959	102	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Molecular cloning of MADM : a catalytically active mammalian_disintegrin-metalloprotease expressed in various cell types .
2646299	0	MAF	69,72	BSF-1	57,62	MAF	BSF-1	17132(Tax:10090)	16189(Tax:10090)	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and sequencing of glycosylation variants of BSF-1 , as a MAF , from the EL-4 leukaemia cell line .
21859424	0	MAF	70,73	macrophage_activating_factor	40,68	MAF	macrophage activating factor	4094	4094	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Phenotype of Gc-globulin influences the macrophage_activating_factor -LRB- MAF -RRB- levels in serum .
3316511	0	MAF	66,69	macrophage_activating_factor	36,64	MAF	macrophage activating factor	4094	4094	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Preparation and antitumor effect of macrophage_activating_factor -LRB- MAF -RRB- encapsulated in liposomes bearing a monoclonal anti-human melanoma -LRB- A375 -RRB- antibody .
6371237	0	MAF	56,59	macrophage_activation_factor	26,54	MAF	macrophage activation factor	4094	4094	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human macrophage_activation_factor -LRB- MAF -RRB- prepared from antigen-stimulated lymphocytes .
4389002	0	MAF	38,41	muscle_activity_factor	14,36	MAF	muscle activity factor	4094	4094	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of muscle_activity_factor -LRB- MAF -RRB- on cardiac contractility and sugar transport .
26067234	0	MAF1	0,4	CDKN1A	15,21	MAF1	CDKN1A	84232	1026	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	MAF1 represses CDKN1A through a Pol III-dependent mechanism .
10488241	0	MAF1	0,4	MFP1	86,90	MAF1	MFP1	543586(Tax:4081)	544122(Tax:4081)	Gene	Gene	START_ENTITY|appos|protein protein|acl|interacting interacting|nmod|END_ENTITY	MAF1 , a novel plant protein interacting with matrix attachment region binding protein MFP1 , is located at the nuclear envelope .
26910647	0	MAF1	0,4	PTEN	74,78	MAF1	PTEN	84232	5728	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Transcription Transcription|compound|END_ENTITY	MAF1 Suppresses AKT-mTOR Signaling and Liver_Cancer through Activation of PTEN Transcription .
20516213	0	MAF1	51,55	mTORC1	0,6	MAF1	mTORC1	84232	382056(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	mTORC1 directly phosphorylates and regulates human MAF1 .
21428925	0	MAF1	0,4	mTORC1	22,28	MAF1	mTORC1	84232	382056(Tax:10090)	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	MAF1 : a new target of mTORC1 .
15531760	0	MAFbx	41,46	SCF	36,39	MAFbx	SCF	114907	4254	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Degradation of MyoD mediated by the SCF -LRB- MAFbx -RRB- ubiquitin ligase .
21126200	0	MAFbx	24,29	atrogin-1	14,23	MAFbx	atrogin-1	67731(Tax:10090)	67731(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Inhibition of atrogin-1 / MAFbx expression by adenovirus-delivered small hairpin RNAs attenuates muscle_atrophy in fasting mice .
18785187	0	MAFbx	32,37	muscle_atrophy_F-box	10,30	MAFbx	muscle atrophy F-box	67731(Tax:10090)	67731(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Decreased muscle_atrophy_F-box -LRB- MAFbx -RRB- expression in regenerating muscle after muscle-damaging exercise .
2433811	0	MAG	95,98	anti-myelin-associated_glycoprotein	58,93	MAG	anti-myelin-associated glycoprotein	4099	4099	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Chronic_T_cell_leukemia with a NK phenotype reacting with anti-myelin-associated_glycoprotein -LRB- MAG -RRB- mouse monoclonal antibody .
9690744	0	MAG	52,55	myelin-associated_glycoprotein	20,50	MAG	myelin-associated glycoprotein	4099	4099	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of myelin-associated_glycoprotein -LRB- MAG -RRB- proteolysis in the human central nervous system .
21574154	0	MAGE	29,33	Melanoma-associated_antigen	0,27	MAGE	Melanoma-associated antigen	57730	57730	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Melanoma-associated_antigen -LRB- MAGE -RRB- expression in the normal mucosa around colorectal_cancer after curative resection : presence of undetectable free cancer cells .
10706124	0	MAGE	35,39	melanoma_antigen	17,33	MAGE	melanoma antigen	17276(Tax:10090)	17276(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mage-b4 , a novel melanoma_antigen -LRB- MAGE -RRB- gene specifically expressed during germ cell differentiation .
9323494	0	MAGE-1	37,43	melanoma_antigen-1	17,35	MAGE-1	melanoma antigen-1	4100	4100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Heterogeneity of melanoma_antigen-1 -LRB- MAGE-1 -RRB- gene and protein expression in malignant_melanoma .
21042944	0	MAGE-1	59,65	melanoma_antigen-encoding_gene-1	25,57	MAGE-1	melanoma antigen-encoding gene-1	4100	4100	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical significance of melanoma_antigen-encoding_gene-1 -LRB- MAGE-1 -RRB- expression and its correlation with poor prognosis in differentiated advanced_gastric_cancer .
18212060	0	MAGE-11	74,81	androgen_receptor	117,134	MAGE-11	androgen receptor	4110	367	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen_receptor .
16140943	0	MAGE-A1	136,143	BORIS	69,74	MAGE-A1	BORIS	4100	140690	Gene	Gene	demethylation|nmod|START_ENTITY END_ENTITY|nmod|demethylation	Conditional expression of the CTCF-paralogous transcriptional factor BORIS in normal cells results in demethylation and derepression of MAGE-A1 and reactivation of other cancer-testis genes .
17957795	0	MAGE-A1	58,65	BORIS	14,19	MAGE-A1	BORIS	4100	140690	Gene	Gene	activation|compound|START_ENTITY association|nmod|activation lack|nmod|association Expression|dep|lack Expression|nmod|END_ENTITY	Expression of BORIS in melanoma : lack of association with MAGE-A1 activation .
25363021	0	MAGE-A1	27,34	BORIS	56,61	MAGE-A1	BORIS	4100	140690	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1 , both interacting with the TATA_binding_protein .
27045082	0	MAGE-A1	0,7	C-JUN	62,67	MAGE-A1	C-JUN	4100	3725	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|amod|END_ENTITY	MAGE-A1 promotes melanoma_proliferation and migration through C-JUN activation .
15496961	0	MAGE-A1	84,91	CD8alpha	132,140	MAGE-A1	CD8alpha	4100	925	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Redirecting human CD4 + T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha .
15316101	0	MAGE-A1	0,7	SKIP	31,35	MAGE-A1	SKIP	4100	22938	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription .
26330556	0	MAGE-A11	60,68	Melanoma_antigen-A11	38,58	MAGE-A11	Melanoma antigen-A11	4110	4110	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Post-translational Down-regulation of Melanoma_antigen-A11 -LRB- MAGE-A11 -RRB- by Human p14-ARF_Tumor_Suppressor .
12525503	0	MAGE-A4	0,7	gankyrin	45,53	MAGE-A4	gankyrin	4103	5716	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity .
26540345	0	MAGE-C2	22,29	Rbx1	36,40	MAGE-C2	Rbx1	51438	9978	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. UNASSIGNED : Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors .
15272023	0	MAGE-D1	55,62	Msx2	26,30	MAGE-D1	Msx2	94275(Tax:10090)	17702(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells .
24481586	0	MAGEA2	86,92	adherens_junction-associated_protein_1	4,42	MAGEA2	adherens junction-associated protein 1	4101	55966	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The adherens_junction-associated_protein_1 is a negative transcriptional regulator of MAGEA2 , which potentiates temozolomide-induced apoptosis in GBM .
25725070	0	MAGI	11,15	RASSF8	31,37	MAGI	RASSF8	37403(Tax:7227)	43096(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye .
15383320	0	MAGI-1	77,83	ESAM	30,34	MAGI-1	ESAM	9223	90952	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts .
21426345	0	MAGI-1	45,51	GLT-1	36,41	MAGI-1	GLT-1	9223	6506	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of glutamate transporter GLT-1 by MAGI-1 .
16339077	0	MAGI-1	0,6	Rap1	23,27	MAGI-1	Rap1	9223	27342	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular_endothelial_cadherin-mediated cell adhesion .
10772923	0	MAGI-1	0,6	beta-catenin	22,34	MAGI-1	beta-catenin	476565(Tax:9615)	477032(Tax:9615)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures .
11274227	0	MAGI-1	49,55	megalin	62,69	MAGI-1	megalin	14924(Tax:10090)	14725(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes .
20353789	0	MAGI-3	84,90	Beta-2_adrenergic_receptor	0,26	MAGI-3	Beta-2 adrenergic receptor	260425	154	Gene	Gene	regulated|nmod|START_ENTITY mediated|ccomp|regulated mediated|nsubj|END_ENTITY	Beta-2_adrenergic_receptor mediated ERK activation is regulated by interaction with MAGI-3 .
16904289	0	MAGI-3	0,6	Erk	43,46	MAGI-3	Erk	260425	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	MAGI-3 regulates LPA-induced activation of Erk and RhoA .
21134377	0	MAGI-3	0,6	NHERF-2	21,28	MAGI-3	NHERF-2	260425	9351	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon_cancer cells .
15908431	0	MAGI1	0,5	Dll1	15,19	MAGI1	Dll1	9223	28514	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface .
24204926	0	MAGL	25,29	Monoacylglycerol_lipase	0,23	MAGL	Monoacylglycerol lipase	23945(Tax:10090)	23945(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Monoacylglycerol_lipase -LRB- MAGL -RRB- inhibition attenuates acute_lung_injury in mice .
24633487	0	MAGL	37,41	monoacylglycerol_lipase	12,35	MAGL	monoacylglycerol lipase	11343	11343	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of monoacylglycerol_lipase -LRB- MAGL -RRB- in the cancer progress .
26490035	0	MAGL	39,43	monoacylglycerol_lipase	14,37	MAGL	monoacylglycerol lipase	23945(Tax:10090)	23945(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoacylglycerol_lipase -LRB- MAGL -RRB- enhances cue-induced reinstatement of nicotine-seeking behavior in mice .
3315986	0	MAGP	77,81	microfibril-associated_glycoprotein	40,75	MAGP	microfibril-associated glycoprotein	281912(Tax:9913)	281912(Tax:9913)	Gene	Gene	localisation|appos|START_ENTITY localisation|nmod|END_ENTITY	The immunohistochemical localisation of microfibril-associated_glycoprotein -LRB- MAGP -RRB- in elastic and non-elastic tissues .
10664011	0	MAGP-1	53,59	microfibril-associated_glycoprotein-1	14,51	MAGP-1	microfibril-associated glycoprotein-1	4237	4237	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of microfibril-associated_glycoprotein-1 -LRB- MAGP-1 -RRB- in human epidermal keratinocytes .
15560107	0	MAGP-1	91,97	microfibril-associated_glycoprotein_1	52,89	MAGP-1	microfibril-associated glycoprotein 1	281912(Tax:9913)	281912(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The pattern of fibrillin deposition correlates with microfibril-associated_glycoprotein_1 -LRB- MAGP-1 -RRB- expression in cultured blood and lymphatic endothelial cells .
15788413	0	MAGP-2	33,39	Jagged1	55,62	MAGP-2	Jagged1	8076	182	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface .
10723723	0	MAGP-2	65,71	microfibril-associated_glycoprotein-2	26,63	MAGP-2	microfibril-associated glycoprotein-2	50530(Tax:10090)	50530(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Organization of the mouse microfibril-associated_glycoprotein-2 -LRB- MAGP-2 -RRB- gene .
19783680	0	MAIL	0,4	IL-6	30,34	MAIL	IL-6	64332	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	MAIL regulates human monocyte IL-6 production .
10733938	0	MAJN	16,20	Jak3	30,34	MAJN	Jak3	9220	3718	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival .
24878628	0	MAL	57,60	Myelin_and_Lymphocyte_Protein	26,55	MAL	Myelin and Lymphocyte Protein	25263(Tax:10116)	25263(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	The Expression Changes of Myelin_and_Lymphocyte_Protein -LRB- MAL -RRB- Following Optic Nerve Crush in Adult Rats Retinal Ganglion Cells .
21218381	0	MAL	22,25	TIRAP	15,20	MAL	TIRAP	4118	114609	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of TIRAP -LRB- MAL -RRB- gene polymorhisms with susceptibility to tuberculosis in a Chinese population .
23196718	0	MAL	47,50	myelin_and_lymphocyte_protein	16,45	MAL	myelin and lymphocyte protein	25263(Tax:10116)	25263(Tax:10116)	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of myelin_and_lymphocyte_protein -LRB- MAL -RRB- after traumatic spinal_cord_injury in rats .
23224601	0	MAL	45,48	myelin_and_lymphocyte_protein	14,43	MAL	myelin and lymphocyte protein	4118	4118	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of myelin_and_lymphocyte_protein -LRB- MAL -RRB- in oral carcinogenesis .
2571505	0	MALA-2	0,6	ICAM-1	51,57	MALA-2	ICAM-1	15894(Tax:10090)	3383	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	MALA-2 , mouse homologue of human adhesion molecule ICAM-1 -LRB- CD54 -RRB- .
26887056	0	MALAT1	20,26	AKAP-9	37,43	MALAT1	AKAP-9	378938	10142	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Long non-coding RNA MALAT1 increases AKAP-9 expression by promoting SRPK1-catalyzed SRSF1 phosphorylation in colorectal_cancer cells .
26964565	0	MALAT1	20,26	CREB	71,75	MALAT1	CREB	378938	1385	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signaling signaling|compound|END_ENTITY	Long non-coding RNA MALAT1 regulates retinal_neurodegeneration through CREB signaling .
26884868	0	MALAT1	37,43	MAPK1	0,5	MALAT1	MAPK1	378938	5594	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway .
26938295	0	MALAT1	49,55	MMP2	93,97	MALAT1	MMP2	378938	4313	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling .
26265046	0	MALAT1	14,20	TDP43	35,40	MALAT1	TDP43	378938	23435	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung_cancer cells in vitro .
27015363	0	MALAT1	19,25	b-catenin	108,117	MALAT1	b-catenin	378938	1499	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Long noncoding RNA MALAT1 promotes malignant development of esophageal_squamous_cell_carcinoma by targeting b-catenin via Ezh2 .
26917489	0	MALAT1	68,74	hsa-miR-448	112,123	MALAT1	hsa-miR-448	378938	554212	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|END_ENTITY	Aberrant KDM5B expression promotes aggressive breast_cancer through MALAT1 overexpression and downregulation of hsa-miR-448 .
26926567	0	MALAT1	0,6	miR-1	92,97	MALAT1	miR-1	378938	79187	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	MALAT1 induced migration and invasion of human breast_cancer cells by competitively binding miR-1 with cdc42 .
16341151	0	MALT1	0,5	BCL10	84,89	MALT1	BCL10	10892	8915	Gene	Gene	aberrations|nsubj|START_ENTITY aberrations|nmod|expression expression|nmod|END_ENTITY	MALT1 and BCL10 aberrations in MALT_lymphomas and their effect on the expression of BCL10 in the tumour cells .
18086859	0	MALT1	82,87	Bcl10	76,81	MALT1	Bcl10	10892	8915	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
21041303	0	MALT1	111,116	Bcl10	104,109	MALT1	Bcl10	10892	8915	Gene	Gene	signalosome|compound|START_ENTITY signalosome|compound|END_ENTITY	Thrombin-dependent NF - -LCB- kappa -RCB- B activation and monocyte/endothelial adhesion are mediated by the CARMA3 Bcl10 MALT1 signalosome .
18086859	0	MALT1	82,87	CARMA1	47,53	MALT1	CARMA1	10892	84433	Gene	Gene	formation|compound|START_ENTITY contributes|nmod|formation contributes|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
18086859	0	MALT1	82,87	CARMA1	69,75	MALT1	CARMA1	10892	84433	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	IkappaB_kinase_beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells .
21041303	0	MALT1	111,116	CARMA3	96,102	MALT1	CARMA3	10892	29775	Gene	Gene	signalosome|compound|START_ENTITY signalosome|compound|END_ENTITY	Thrombin-dependent NF - -LCB- kappa -RCB- B activation and monocyte/endothelial adhesion are mediated by the CARMA3 Bcl10 MALT1 signalosome .
15598810	0	MALT1	0,5	CD40	44,48	MALT1	CD40	10892	958	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-kappa_B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells .
16891304	1	MALT1	49,54	TRAF1	104,109	MALT1	TRAF1	10892	7185	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2 .
17287209	0	MALT1	30,35	TRAF6	8,13	MALT1	TRAF6	10892	7189	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions .
19234489	0	MALT1	36,41	c-IAP2	29,35	MALT1	c-IAP2	10892	330	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	TRAF2-binding BIR1 domain of c-IAP2 / MALT1 fusion protein is essential for activation of NF-kappaB .
23727036	0	MALT1	50,55	mucosa-associated_lymphoid_tissue_1	13,48	MALT1	mucosa-associated lymphoid tissue 1	10892	10892	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A homozygous mucosa-associated_lymphoid_tissue_1 -LRB- MALT1 -RRB- mutation in a family with combined_immunodeficiency .
22158899	0	MALT1	85,90	mucosa-associated_lymphoid_tissue_lymphoma_translocation_1	25,83	MALT1	mucosa-associated lymphoid tissue lymphoma translocation 1	10892	10892	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Crystal structure of the mucosa-associated_lymphoid_tissue_lymphoma_translocation_1 -LRB- MALT1 -RRB- paracaspase region .
22158899	0	MALT1	85,90	paracaspase	92,103	MALT1	paracaspase	10892	10892	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Crystal structure of the mucosa-associated_lymphoid_tissue_lymphoma_translocation_1 -LRB- MALT1 -RRB- paracaspase region .
24285545	0	MAM	143,146	mitochondria-associated_endoplasmic_reticulum_membrane	87,141	MAM	mitochondria-associated endoplasmic reticulum membrane	6445	6445	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Regulation of mitochondrial_antiviral_signaling -LRB- MAVS -RRB- expression and signaling by the mitochondria-associated_endoplasmic_reticulum_membrane -LRB- MAM -RRB- protein Gp78 .
23029358	0	MAML1	0,5	EGR1	30,34	MAML1	EGR1	9794	1958	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	MAML1 acts cooperatively with EGR1 to activate EGR1-regulated promoters : implications for nephrogenesis and the development of renal_cancer .
19740771	0	MAML1	68,73	GSK3beta	0,8	MAML1	GSK3beta	9794	2932	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	GSK3beta is a negative regulator of the transcriptional coactivator MAML1 .
23326237	0	MAML1	0,5	Runx2	47,52	MAML1	Runx2	103806(Tax:10090)	12393(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development .
17317671	0	MAML1	20,25	p53	41,44	MAML1	p53	9794	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The notch regulator MAML1 interacts with p53 and functions as a coactivator .
26033683	0	MAML1	117,122	p53	0,3	MAML1	p53	9794	7157	Gene	Gene	Associating|nmod|START_ENTITY Modulates|advcl|Associating Modulates|nsubj|END_ENTITY	p53 Modulates Notch Signaling in MCF-7 Breast_Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1 .
25182847	0	MAN1	25,29	BMAL1	54,59	MAN1	BMAL1	23592	406	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Nuclear envelope protein MAN1 regulates clock through BMAL1 .
20036230	0	MAN1	34,38	BMP	51,54	MAN1	BMP	37838(Tax:7227)	33432(Tax:7227)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins .
15601644	0	MAN1	0,4	Smad2	63,68	MAN1	Smad2	23592	4087	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	MAN1 , an integral protein of the inner nuclear membrane , binds Smad2 and Smad3 and antagonizes transforming_growth_factor-beta signaling .
17329363	0	MAN1	29,33	TGFbeta	44,51	MAN1	TGFbeta	380664(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac .
9192839	0	MANB	65,69	lysosomal_alpha-mannosidase	31,58	MANB	lysosomal alpha-mannosidase	4125	4125	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure of the human lysosomal_alpha-mannosidase gene -LRB- MANB -RRB- .
1871416	0	MAO	25,28	Angiotensin_II	0,14	MAO	Angiotensin II	29253(Tax:10116)	24179(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Angiotensin_II increases MAO activity in rat central nervous system .
2696882	2	MAO	93,96	Monoamine_oxidase	74,91	MAO	Monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Monoamine_oxidase -LRB- MAO -RRB- activity in the rat brain after porta - caval shunt using 2 different methods -RSB- .
16797252	0	MAO	62,65	monoamine_oxidase	43,60	MAO	monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Immobilization stress increases endogenous monoamine_oxidase -LRB- MAO -RRB- inhibitor in rat liver .
2063399	0	MAO	39,42	monoamine_oxidase	20,37	MAO	monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Gossypol effects on monoamine_oxidase -LRB- MAO -RRB- activity in several organs of term rats .
2127505	0	MAO	41,44	monoamine_oxidase	22,39	MAO	monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of various monoamine_oxidase -LRB- MAO -RRB- inhibitors on the response of blood pressure of rats and cats to tyramine .
24373881	0	MAO	33,36	monoamine_oxidase	14,31	MAO	monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase -LRB- MAO -RRB- by b-carbolines and their interactions in live neuronal -LRB- PC12 -RRB- and liver -LRB- HuH-7 and MH1C1 -RRB- cells .
2626178	1	MAO	103,106	monoamine_oxidase	84,101	MAO	monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	I. Changes in monoamine_oxidase -LRB- MAO -RRB- activity in the cerebral cortex and cerebellum of rats after portacaval shunt -RSB- .
2873956	0	MAO	59,62	monoamine_oxidase	40,57	MAO	monoamine oxidase	100136729(Tax:8022)	100136729(Tax:8022)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The characteristics and distribution of monoamine_oxidase -LRB- MAO -RRB- activity in different tissues of the rainbow_trout , Salmo_gairdneri .
523335	0	MAO	40,43	monoamine_oxidase	21,38	MAO	monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of selective monoamine_oxidase -LRB- MAO -RRB- inhibitors on conditioned avoidance responses -LRB- CAR -RRB- of rats .
708472	0	MAO	46,49	monoamine_oxidase	27,44	MAO	monoamine oxidase	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effect of reserpine on the monoamine_oxidase -LRB- MAO -RRB- activity in rat liver and brain .
3148140	0	MAO-A	24,29	MAO-B	35,40	MAO-A	MAO-B	29253(Tax:10116)	25750(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Selective inhibition of MAO-A , not MAO-B , results in antidepressant-like effects on DRL 72-s behavior .
22169038	0	MAO-A	16,21	SIRT1	0,5	MAO-A	SIRT1	4128	23411	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive .
3131149	0	MAO-A	30,35	monoamine_oxidase-A	9,28	MAO-A	monoamine oxidase-A	17161(Tax:10090)	17161(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role for monoamine_oxidase-A -LRB- MAO-A -RRB- in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog , 2 ` Me-MPTP .
7845378	0	MAO-A	69,74	monoamine_oxidase-A	48,67	MAO-A	monoamine oxidase-A	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effect of aluminium -LRB- Al -RRB- on brain mitochondrial monoamine_oxidase-A -LRB- MAO-A -RRB- activity -- an in vitro kinetic study .
16192108	0	MAO-A	107,112	monoamine_oxidase_A	86,105	MAO-A	monoamine oxidase A	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Stereospecific oxidation of the -LRB- S -RRB- - enantiomer of RS-8359 , a selective and reversible monoamine_oxidase_A -LRB- MAO-A -RRB- inhibitor , by aldehyde oxidase .
17298646	0	MAO-A	25,30	monoamine_oxidase_A	4,23	MAO-A	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The monoamine_oxidase_A -LRB- MAO-A -RRB- gene , family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption .
3148140	0	MAO-B	35,40	MAO-A	24,29	MAO-B	MAO-A	25750(Tax:10116)	29253(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of MAO-A , not MAO-B , results in antidepressant-like effects on DRL 72-s behavior .
24011391	0	MAO-B	21,26	Monoamine_oxidase-B	0,19	MAO-B	Monoamine oxidase-B	4129	4129	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Monoamine_oxidase-B -LRB- MAO-B -RRB- inhibitors : implications for disease-modification in Parkinson 's _ disease .
14692725	0	MAO-B	35,40	monoamine_oxidase_B	14,33	MAO-B	monoamine oxidase B	25750(Tax:10116)	25750(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of monoamine_oxidase_B -LRB- MAO-B -RRB- by Chinese herbal medicines .
15959855	0	MAO-B	30,35	monoamine_oxidase_B	9,28	MAO-B	monoamine oxidase B	4129	4129	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Platelet monoamine_oxidase_B -LRB- MAO-B -RRB- activity and its relationship to DL-fenfluramine-induced prolactin response in healthy men .
25600407	0	MAO-B	78,83	monoamine_oxidase_B	57,76	MAO-B	monoamine oxidase B	4129	4129	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|nmod|END_ENTITY	Reversible and irreversible small molecule inhibitors of monoamine_oxidase_B -LRB- MAO-B -RRB- investigated by biophysical techniques .
1906004	0	MAO-B	56,61	monoamine_oxidase_type_B	30,54	MAO-B	monoamine oxidase type B	4129	4129	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Measurement of human cerebral monoamine_oxidase_type_B -LRB- MAO-B -RRB- activity with positron emission tomography -LRB- PET -RRB- : a dose ranging study with the reversible inhibitor Ro_19-6327 .
19168625	0	MAOA	26,30	Monoamine_oxidase_A	0,19	MAOA	Monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Monoamine_oxidase_A gene -LRB- MAOA -RRB- predicts behavioral_aggression following provocation .
20046877	0	MAOA	26,30	Monoamine_oxidase_A	0,19	MAOA	Monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Monoamine_oxidase_A gene -LRB- MAOA -RRB- associated with attitude towards longshot risks .
24173666	0	MAOA	83,87	Monoamine_oxidase_A	57,76	MAOA	Monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sudden_infant_death_syndrome -LRB- SIDS -RRB- and polymorphisms in Monoamine_oxidase_A gene -LRB- MAOA -RRB- : a revisit .
23221997	0	MAOA	6,10	TPH1	0,4	MAOA	TPH1	4128	7166	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	TPH1 , MAOA , serotonin receptor 2A and 2C genes in citalopram response : possible effect in melancholic and psychotic_depression .
10402508	0	MAOA	37,41	monoamine_oxidase_A	16,35	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of the monoamine_oxidase_A -LRB- MAOA -RRB- gene in bipolar affective_disorder by association studies , meta-analyses , and sequencing of the promoter .
17894408	0	MAOA	64,68	monoamine_oxidase_A	38,57	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Meta-study on association between the monoamine_oxidase_A gene -LRB- MAOA -RRB- and schizophrenia .
19224413	0	MAOA	36,40	monoamine_oxidase_A	15,34	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of monoamine_oxidase_A -LRB- MAOA -RRB- polymorphisms and clinical subgroups of major_depressive_disorders in the Han Chinese population .
19368859	0	MAOA	45,49	monoamine_oxidase_A	24,43	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	An association study of monoamine_oxidase_A -LRB- MAOA -RRB- gene polymorphism in methamphetamine psychosis .
21698196	0	MAOA	101,105	monoamine_oxidase_A	75,94	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic susceptibility for individual cooperation preferences : the role of monoamine_oxidase_A gene -LRB- MAOA -RRB- in the voluntary provision of public goods .
22162429	0	MAOA	53,57	monoamine_oxidase_A	32,51	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Study of a possible role of the monoamine_oxidase_A -LRB- MAOA -RRB- gene in paranoid schizophrenia among a Chinese population .
22948232	0	MAOA	64,68	monoamine_oxidase_A	43,62	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence that the methylation state of the monoamine_oxidase_A -LRB- MAOA -RRB- gene predicts brain activity of MAO_A enzyme in healthy men .
24422758	0	MAOA	60,64	monoamine_oxidase_A	39,58	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Family-based association study between monoamine_oxidase_A -LRB- MAOA -RRB- gene promoter VNTR polymorphism and Tourette 's _ syndrome in Chinese Han population .
26298506	0	MAOA	121,125	monoamine_oxidase_A	100,119	MAOA	monoamine oxidase A	4128	4128	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between variable number of tandem repeats -LRB- VNTR -RRB- polymorphism in the promoter region of monoamine_oxidase_A -LRB- MAOA -RRB- gene and susceptibility to heroin_dependence .
10091612	0	MAOB	39,43	monoamine_oxidase_B	18,37	MAOB	monoamine oxidase B	4129	4129	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variations in the monoamine_oxidase_B -LRB- MAOB -RRB- gene are associated with Parkinson 's _ disease .
24658549	0	MAOB	46,50	monoamine_oxidase_B	25,44	MAOB	monoamine oxidase B	4129	4129	Gene	Gene	relationship|appos|START_ENTITY relationship|nmod|END_ENTITY	The relationship between monoamine_oxidase_B -LRB- MAOB -RRB- A644G polymorphism and Parkinson_disease risk : a meta-analysis .
19883764	0	MAO_A	116,121	monoamine_oxidase_A	46,65	MAO A	monoamine oxidase A	4128	29253(Tax:10116)	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|nmod|END_ENTITY	High-level expression and purification of rat monoamine_oxidase_A -LRB- MAO_A -RRB- in Pichia_pastoris : comparison with human MAO_A .
10906284	0	MAP	43,46	microtubule-associated_protein	11,41	MAP	microtubule-associated protein	54141(Tax:10090)	54141(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of microtubule-associated_protein -LRB- MAP -RRB- expression on methylmercury-induced microtubule disassembly .
8383965	0	MAP	106,109	microtubule-associated_protein_2	72,104	MAP	microtubule-associated protein 2	4133	4133	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated_protein_2 -LRB- MAP -RRB- kinase and a MAP kinase kinase in polymorphonuclear leucocytes .
18455509	0	MAP-2	73,78	Gap-43	15,21	MAP-2	Gap-43	25595(Tax:10116)	29423(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Gap-43 -LRB- neuromodulin -RRB- with microtubule-associated protein MAP-2 in neuronal cells .
12079519	0	MAP-2	67,72	microtubule-associated_protein-2	33,65	MAP-2	microtubule-associated protein-2	4133	4133	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunocytochemical expression of microtubule-associated_protein-2 -LRB- MAP-2 -RRB- in small_cell_lung_cancer cell lines with neuronal-like processes .
1484385	0	MAP-2	46,51	microtubule-associated_protein_2	12,44	MAP-2	microtubule-associated protein 2	4133	4133	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of microtubule-associated_protein_2 -LRB- MAP-2 -RRB- in neuronal growth , plasticity , and degeneration .
7566447	0	MAP-2	57,62	microtubule-associated_protein_2	23,55	MAP-2	microtubule-associated protein 2	4133	4133	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of microtubule-associated_protein_2 -LRB- MAP-2 -RRB- in neocortex in Rett_syndrome .
11546790	0	MAP-2c	18,24	Fyn	11,14	MAP-2c	Fyn	4133	2534	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Fyn to MAP-2c through an SH3 binding domain .
15536091	0	MAP-2c	25,31	Fyn	0,3	MAP-2c	Fyn	4133	2534	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Fyn phosphorylates human MAP-2c on tyrosine 67 .
6704120	0	MAP1	19,23	MAP2	0,4	MAP1	MAP2	64112	4133	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	MAP2 competes with MAP1 for binding to microtubules .
8701988	0	MAP17	84,89	membrane-associated_protein	55,82	MAP17	membrane-associated protein	10158	10158	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Identification and partial characterization of a novel membrane-associated_protein -LRB- MAP17 -RRB- up-regulated in human carcinomas and modulating cell replication and tumor growth .
7629894	0	MAP1A	70,75	microtubule-associated_protein_1A	35,68	MAP1A	microtubule-associated protein 1A	4130	4130	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Brain-specific expression of human microtubule-associated_protein_1A -LRB- MAP1A -RRB- gene and its assignment to human chromosome 15 .
8714690	0	MAP1A	51,56	microtubule-associated_protein_1A	16,49	MAP1A	microtubule-associated protein 1A	17754(Tax:10090)	17754(Tax:10090)	Gene	Gene	Accumulation|appos|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of microtubule-associated_protein_1A -LRB- MAP1A -RRB- in differentiating P19 embryonal_carcinoma cells .
8812494	0	MAP1A	41,46	microtubule-associated_protein_1a	6,39	MAP1A	microtubule-associated protein 1a	4130	4130	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human microtubule-associated_protein_1a -LRB- MAP1A -RRB- gene : genomic organization , cDNA sequence , and developmental - and tissue-specific expression .
22779921	0	MAP1A	67,72	osteopontin	39,50	MAP1A	osteopontin	4130	6696	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability , apoptosis and protein degradation in the human brain .
7906711	0	MAP1B	91,96	Claustrin	0,9	MAP1B	Claustrin	396174(Tax:9031)	396174(Tax:9031)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Claustrin , an antiadhesive neural keratan sulfate proteoglycan , is structurally related to MAP1B .
23572079	0	MAP1B	0,5	EB1/3	53,58	MAP1B	EB1/3	4131	22919;22924	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells .
11733059	0	MAP1B	48,53	Futsch	62,68	MAP1B	Futsch	5740544(Tax:7227)	5740544(Tax:7227)	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function .
14622124	0	MAP1B	37,42	GSK3beta	46,54	MAP1B	GSK3beta	29456(Tax:10116)	84027(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY activates|dobj|phosphorylation activates|nmod|END_ENTITY	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
15737742	0	MAP1B	98,103	GSK3beta	56,64	MAP1B	GSK3beta	29456(Tax:10116)	84027(Tax:10116)	Gene	Gene	phosphorylate|dobj|START_ENTITY enables|xcomp|phosphorylate END_ENTITY|acl:relcl|enables	The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth .
16949836	0	MAP1B	145,150	GSK3beta	112,120	MAP1B	GSK3beta	5740544(Tax:7227)	31248(Tax:7227)	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	The Drosophila microtubule associated protein Futsch is phosphorylated by Shaggy/Zeste-white _ 3 at an homologous GSK3beta phosphorylation site in MAP1B .
15731007	0	MAP1B	50,55	Glycogen_synthase_kinase-3beta	0,30	MAP1B	Glycogen synthase kinase-3beta	29456(Tax:10116)	84027(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Glycogen_synthase_kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons .
20304030	0	MAP1B	0,5	NR3A	41,45	MAP1B	NR3A	17755(Tax:10090)	242443(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations .
20719958	0	MAP1B	0,5	Rac1	60,64	MAP1B	Rac1	17755(Tax:10090)	19353(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY	MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity .
19912782	0	MAP1B	47,52	microtubule-associated_protein	15,45	MAP1B	microtubule-associated protein	4131	51115	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of microtubule-associated_protein -LRB- MAP1B -RRB- with growing axons in cultured hippocampal neurons .
26654586	0	MAP1LC3B	21,29	BAG3	0,4	MAP1LC3B	BAG3	81631	9531	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism .
26571030	0	MAP1S	83,88	TGFb	27,31	MAP1S	TGFb	55201	7040	Gene	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	Transforming Growth Factor TGFb Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic_Ductal_Adenocarcinomas .
24466264	0	MAP1S	0,5	TLR5	34,38	MAP1S	TLR5	55201	7100	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	MAP1S controls breast_cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression .
16597486	0	MAP2	21,25	ERK3	0,4	MAP2	ERK3	25595(Tax:10116)	58840(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	ERK3 associates with MAP2 and is involved in glucose-induced insulin secretion .
6704120	0	MAP2	0,4	MAP1	19,23	MAP2	MAP1	4133	64112	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	MAP2 competes with MAP1 for binding to microtubules .
15450909	0	MAP2	31,35	Microtubule-associated_protein	0,30	MAP2	Microtubule-associated protein	4133	51115	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Microtubule-associated_protein MAP2 expression in olfactory bulb in schizophrenia .
1905296	0	MAP2	142,146	microtubule-associated_protein	28,58	MAP2	microtubule-associated protein	4133	4134	Gene	Gene	domains|nmod|START_ENTITY contains|nmod|domains contains|nsubj|END_ENTITY	Non-neuronal 210 x 10 -LRB- 3 -RRB- Mr microtubule-associated_protein -LRB- MAP4 -RRB- contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau .
3121794	0	MAP2	67,71	microtubule-associated_protein	16,46	MAP2	microtubule-associated protein	4133	51115	Gene	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	A 70-kilodalton microtubule-associated_protein -LRB- MAP2c -RRB- , related to MAP2 .
17229541	0	MAP2	45,49	microtubule-associated_protein-2	11,43	MAP2	microtubule-associated protein-2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Changes in microtubule-associated_protein-2 -LRB- MAP2 -RRB- expression during development and after status_epilepticus in the immature rat hippocampus .
2484443	0	MAP2	48,52	microtubule-associated_protein_2	14,46	MAP2	microtubule-associated protein 2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Regulation of microtubule-associated_protein_2 -LRB- MAP2 -RRB- mRNA expression during rat brain development .
3512042	0	MAP2	65,69	microtubule-associated_protein_2	31,63	MAP2	microtubule-associated protein 2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and distribution of microtubule-associated_protein_2 -LRB- MAP2 -RRB- in neuroblastoma and primary neuronal cells .
8965322	0	MAP2	45,49	microtubule-associated_protein_2	11,43	MAP2	microtubule-associated protein 2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Diminished microtubule-associated_protein_2 -LRB- MAP2 -RRB- immunoreactivity following cortical impact_brain_injury .
2026175	0	MAP2	48,52	microtubule_associated_protein_2	14,46	MAP2	microtubule associated protein 2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of microtubule_associated_protein_2 -LRB- MAP2 -RRB- expression by nerve_growth_factor in PC12 cells .
2026175	0	MAP2	48,52	nerve_growth_factor	68,87	MAP2	nerve growth factor	25595(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulation of microtubule_associated_protein_2 -LRB- MAP2 -RRB- expression by nerve_growth_factor in PC12 cells .
8579600	0	MAP2	46,50	porin	18,23	MAP2	porin	4133	7416	Gene	Gene	site|nmod|START_ENTITY Identification|nmod|site Identification|nmod|END_ENTITY	Identification of porin as a binding site for MAP2 .
26609480	0	MAP2K1	48,54	MiR-449a	0,8	MAP2K1	MiR-449a	5604	554213	Gene	Gene	inhibiting|dobj|START_ENTITY suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	MiR-449a suppresses cell invasion by inhibiting MAP2K1 in non-small_cell_lung_cancer .
20128690	0	MAP3K1	0,6	Axin1	35,40	MAP3K1	Axin1	4214	8312	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway .
15670770	0	MAP3K8	56,62	CD40	69,73	MAP3K8	CD40	1326	958	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	TRAF-dependent association of protein kinase Tpl2/COT1 -LRB- MAP3K8 -RRB- with CD40 .
20736176	0	MAP3K8	10,16	Cot/tpl2	0,8	MAP3K8	Cot/tpl2	26410(Tax:10090)	26410(Tax:10090)	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Cot/tpl2 -LRB- MAP3K8 -RRB- mediates myeloperoxidase activity and hypernociception following peripheral inflammation .
16804917	0	MAP4	75,79	microtubule-associated_protein_4	41,73	MAP4	microtubule-associated protein 4	4134	4134	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel fusion of the MALT1 gene and the microtubule-associated_protein_4 -LRB- MAP4 -RRB- gene occurs in diffuse large B-cell_lymphoma .
22801218	0	MAP4K1	29,35	Pdcd4	0,5	MAP4K1	Pdcd4	11184	27250	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc .
1517758	0	MAP5	68,72	microtubule-associated_protein_5	34,66	MAP5	microtubule-associated protein 5	4131	4131	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of microtubule-associated_protein_5 -LRB- MAP5 -RRB- in glial cells in multiple_system_atrophy .
9440798	0	MAP5	63,67	microtubule-associated_protein_5	29,61	MAP5	microtubule-associated protein 5	4131	4131	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Immunohistochemical study of microtubule-associated_protein_5 -LRB- MAP5 -RRB- expression in the developing human brain .
9533556	0	MAP5	58,62	microtubule-associated_protein_5	24,56	MAP5	microtubule-associated protein 5	4131	4131	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of microtubule-associated_protein_5 -LRB- MAP5 -RRB- in the molecular layer of cerebellum in preterm infants with olivocerebellar_lesions .
21455028	0	MAP65-1	21,28	PLEIADE	75,82	MAP65-1	PLEIADE	835616(Tax:3702)	835234(Tax:3702)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	Arabidopsis_thaliana MAP65-1 and MAP65-2 function redundantly with MAP65-3 / PLEIADE in cytokinesis downstream of MPK4 .
22672907	0	MAP9	19,23	ASAP	13,17	MAP9	ASAP	79884	79884	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of ASAP -LRB- MAP9 -RRB- contributes to p53 stabilization in response to DNA damage .
21057191	0	MAPK	14,18	MKP2	64,68	MAPK	MKP2	837559(Tax:3702)	819784(Tax:3702)	Gene	Gene	signaling|compound|START_ENTITY Regulation|nmod|signaling Regulation|nmod|END_ENTITY	Regulation of MAPK signaling and cell death by MAPK phosphatase MKP2 .
10606727	0	MAPK	31,35	Nerve_growth_factor	0,19	MAPK	Nerve growth factor	50689(Tax:10116)	310738(Tax:10116)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Nerve_growth_factor stimulates MAPK via the low affinity receptor p75 -LRB- LNTR -RRB- .
12943808	0	MAPK	112,116	p38	108,111	MAPK	p38	5594	5594	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha -LRB- i -RRB- - and pi3-kinase-dependent p38 -LRB- MAPK -RRB- activation .
26609108	0	MAPK-Interacting_Protein_Kinases	43,75	ZEB1	27,31	MAPK-Interacting Protein Kinases	ZEB1	538	6935	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Differential Regulation of ZEB1 and EMT by MAPK-Interacting_Protein_Kinases -LRB- MNK -RRB- and eIF4E in Pancreatic_Cancer .
16424170	0	MAPK-activated_protein_kinase_2	97,128	TNF-alpha	22,31	MAPK-activated protein kinase 2	TNF-alpha	9261	7124	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated_protein_kinase_2 .
26884868	0	MAPK1	0,5	MALAT1	37,43	MAPK1	MALAT1	5594	378938	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway .
24139413	0	MAPK1	80,85	MiR-378	0,7	MAPK1	MiR-378	5594	494327	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-378 inhibits progression of human gastric_cancer MGC-803 cells by targeting MAPK1 in vitro .
24974389	0	MAPK1	66,71	mitogen-activated_protein_kinase_1	30,64	MAPK1	mitogen-activated protein kinase 1	101800319	101800319	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of the duck mitogen-activated_protein_kinase_1 -LRB- MAPK1 -RRB- gene and the development of a quantitative real-time PCR assay to detect its expression .
21084714	0	MAPK14	0,6	MAPK3/1	23,30	MAPK14	MAPK3/1	1432	5595;5594	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	MAPK14 cooperates with MAPK3/1 to regulate endothelin-1-mediated prostaglandin synthase 2 induction and survival in leiomyoma but not in normal myometrial cells .
20808308	0	MAPK3/1	91,98	AMP-activated_protein_kinase	27,55	MAPK3/1	AMP-activated protein kinase	5595;5594	5563	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of AMP-activated_protein_kinase expression and modifying effect of MAPK3/1 in colorectal_cancer .
21084714	0	MAPK3/1	23,30	MAPK14	0,6	MAPK3/1	MAPK14	5595;5594	1432	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	MAPK14 cooperates with MAPK3/1 to regulate endothelin-1-mediated prostaglandin synthase 2 induction and survival in leiomyoma but not in normal myometrial cells .
22508986	0	MAPK6	81,86	extracellular_signal-regulated_kinase_3	4,43	MAPK6	extracellular signal-regulated kinase 3	50772(Tax:10090)	50772(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	The extracellular_signal-regulated_kinase_3 -LRB- mitogen-activated_protein_kinase_6 -LSB- MAPK6 -RSB- -RRB- - MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology .
22508986	0	MAPK6	81,86	mitogen-activated_protein_kinase_6	45,79	MAPK6	mitogen-activated protein kinase 6	50772(Tax:10090)	50772(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	The extracellular_signal-regulated_kinase_3 -LRB- mitogen-activated_protein_kinase_6 -LSB- MAPK6 -RSB- -RRB- - MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology .
16095439	0	MAPKAP-K2	44,53	Nogo-B	0,6	MAPKAP-K2	Nogo-B	9261	57142	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Nogo-B is a new physiological substrate for MAPKAP-K2 .
11042204	0	MAPKAPK-2	21,30	Akt	97,100	MAPKAPK-2	Akt	9261	207	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils .
16086037	0	MAPKAPK-2	107,116	HSP27	117,122	MAPKAPK-2	HSP27	289014(Tax:10116)	24471(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Mechanisms of xenon - and isoflurane-induced preconditioning - a potential link to the cytoskeleton via the MAPKAPK-2 / HSP27 pathway .
11042204	0	MAPKAPK-2	21,30	p38	0,3	MAPKAPK-2	p38	9261	1432	Gene	Gene	functions|compound|START_ENTITY functions|amod|END_ENTITY	p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils .
26280535	0	MAPKAPK2	15,23	mTOR	0,4	MAPKAPK2	mTOR	9261	21977(Tax:10090)	Gene	Gene	translation|compound|START_ENTITY regulates|dobj|translation regulates|nsubj|END_ENTITY	mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype .
26419804	0	MAPKAPK2	24,32	mTOR	9,13	MAPKAPK2	mTOR	9261	21977(Tax:10090)	Gene	Gene	translation|compound|START_ENTITY regulates|dobj|translation regulates|nsubj|END_ENTITY	Erratum : mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype .
9480836	0	MAPKAPK5	0,8	extracellular-regulated_kinase	106,136	MAPKAPK5	extracellular-regulated kinase	8550	5594	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	MAPKAPK5 , a novel mitogen-activated protein kinase -LRB- MAPK -RRB- - activated protein kinase , is a substrate of the extracellular-regulated_kinase -LRB- ERK -RRB- and p38 kinase .
22950522	0	MAPKAPK5	119,127	mitogen-activated_protein_kinase-activated_protein_kinase_5	58,117	MAPKAPK5	mitogen-activated protein kinase-activated protein kinase 5	8550	8550	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacokinetics , safety , and tolerability of GLPG0259 , a mitogen-activated_protein_kinase-activated_protein_kinase_5 -LRB- MAPKAPK5 -RRB- inhibitor , given as single and multiple doses to healthy male subjects .
26299622	0	MAPKAP_kinase_2	0,15	IL-10	26,31	MAPKAP kinase 2	IL-10	9261	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MAPKAP_kinase_2 regulates IL-10 expression and prevents formation of intrahepatic myeloid cell aggregates during cytomegalovirus_infections .
15094067	0	MAPKAP_kinase_2	25,40	P66	0,3	MAPKAP kinase 2	P66	9261	10714	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	P66 -LRB- ShcA -RRB- interacts with MAPKAP_kinase_2 and regulates its activity .
10318869	0	MAPKAP_kinase_2	0,15	serum_response_factor	31,52	MAPKAP kinase 2	serum response factor	17164(Tax:10090)	20807(Tax:10090)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	MAPKAP_kinase_2 phosphorylates serum_response_factor in vitro and in vivo .
14688255	0	MAPKAP_kinase_2	0,15	tristetraprolin	31,46	MAPKAP kinase 2	tristetraprolin	17164(Tax:10090)	22695(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	MAPKAP_kinase_2 phosphorylates tristetraprolin on in vivo sites including Ser178 , a site required for 14-3-3 binding .
26443375	0	MAPKKK18	33,41	ABI1	81,85	MAPKKK18	ABI1	839324(Tax:3702)	828714(Tax:3702)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Arabidopsis ABA-activated kinase MAPKKK18 is regulated by protein phosphatase 2C ABI1 and the ubiquitin proteasome pathway .
21841136	0	MAPK_kinase_3	0,13	IL-4	59,63	MAPK kinase 3	IL-4	26397(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	MAPK_kinase_3 specifically regulates Fc epsilonRI-mediated IL-4 production by mast cells .
17848570	0	MAPK_phosphatase-1	8,26	JNK	54,57	MAPK phosphatase-1	JNK	1843	5599	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of MAPK_phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells .
15269202	0	MAPK_phosphatase-1	8,26	MKP-1	28,33	MAPK phosphatase-1	MKP-1	1843	1843	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of MAPK_phosphatase-1 -LRB- MKP-1 -RRB- in adipocyte differentiation .
21558315	0	MAPK_phosphatase-1	0,18	MKP-1	20,25	MAPK phosphatase-1	MKP-1	1843	1843	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MAPK_phosphatase-1 -LRB- MKP-1 -RRB- expression is up-regulated by hCG/cAMP and modulates steroidogenesis in MA-10 Leydig cells .
21068409	0	MAPK_phosphatase-1	21,39	MicroRNA-101	0,12	MAPK phosphatase-1	MicroRNA-101	19252(Tax:10090)	387143(Tax:10090)	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-101 targets MAPK_phosphatase-1 to regulate the activation of MAPKs in macrophages .
20178133	0	MAPK_phosphatase_1	129,147	MAPK_phosphatase_1	195,213	MAPK phosphatase 1	MAPK phosphatase 1	19252(Tax:10090)	19252(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Aurothiomalate inhibits cyclooxygenase_2 , matrix_metalloproteinase_3 , and interleukin-6 expression in chondrocytes by increasing MAPK_phosphatase_1 expression and decreasing p38 phosphorylation : MAPK_phosphatase_1 as a novel target for antirheumatic drugs .
20178133	0	MAPK_phosphatase_1	195,213	MAPK_phosphatase_1	129,147	MAPK phosphatase 1	MAPK phosphatase 1	19252(Tax:10090)	19252(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Aurothiomalate inhibits cyclooxygenase_2 , matrix_metalloproteinase_3 , and interleukin-6 expression in chondrocytes by increasing MAPK_phosphatase_1 expression and decreasing p38 phosphorylation : MAPK_phosphatase_1 as a novel target for antirheumatic drugs .
26159201	0	MAPT	29,33	PSEN1	10,15	MAPT	PSEN1	4137	5663	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer 's _ disease .
19558713	0	MAPT	64,68	microtubule-associated_protein_tau	28,62	MAPT	microtubule-associated protein tau	4137	4137	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of the H1 haplotype of microtubule-associated_protein_tau -LRB- MAPT -RRB- gene in Greek patients with Parkinson 's _ disease .
20579400	0	MAPT	69,73	microtubule-associated_protein_tau	33,67	MAPT	microtubule-associated protein tau	4137	4137	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The estrogen_receptor influences microtubule-associated_protein_tau -LRB- MAPT -RRB- expression and the selective estrogen_receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast_cancer cells .
6343400	0	MAP_2	49,54	microtubule-associated_protein_2	15,47	MAP 2	microtubule-associated protein 2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of microtubule-associated_protein_2 -LRB- MAP_2 -RRB- with microtubules and intermediate filaments in cultured brain cells .
11476570	0	MAP_kinase	14,24	BMP-4	32,37	MAP kinase	BMP-4	398985(Tax:8355)	399322(Tax:8355)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MAP_kinase by the BMP-4 / TAK1 pathway in Xenopus ectoderm .
8398135	0	MAP_kinase	34,44	Mitogen-activated_protein_kinase	0,32	MAP kinase	Mitogen-activated protein kinase	397785(Tax:8355)	397785(Tax:8355)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Mitogen-activated_protein_kinase -LRB- MAP_kinase -RRB- activation in Xenopus oocytes : roles of MPF and protein synthesis .
8690082	0	MAP_kinase_kinase	14,31	MEK	33,36	MAP kinase kinase	MEK	5609	5609	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of MAP_kinase_kinase -LRB- MEK -RRB- blocks endothelial PGI2 release but has no effect on von_Willebrand factor secretion or E-selectin expression .
10623478	0	MAP_kinase_kinase	27,44	MEK1	46,50	MAP kinase kinase	MEK1	26395(Tax:10090)	26395(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Constitutive activation of MAP_kinase_kinase -LRB- MEK1 -RRB- is critical and sufficient for the activation of MMP-2 .
8414521	0	MAP_kinase_kinase_kinase	34,58	Raf	60,63	MAP kinase kinase kinase	Raf	4216	22882	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Specific association of activated MAP_kinase_kinase_kinase -LRB- Raf -RRB- with the plasma membranes of ras-transformed retinal cells .
11055544	0	MAP_kinase_phosphatase-1	109,133	MKP-1	135,140	MAP kinase phosphatase-1	MKP-1	1843	1843	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Substitution of two insulin receptor carboxy-terminal tyrosines with phenylalanine impairs the expression of MAP_kinase_phosphatase-1 -LRB- MKP-1 -RRB- mRNA .
20547488	0	MAP_kinase_phosphatase-1	66,90	p38alpha	23,31	MAP kinase phosphatase-1	p38alpha	1843	1432	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP_kinase_phosphatase-1 determines cellular sensitivity to UV radiation .
19091959	0	MAP_kinase_phosphatase-3	105,129	Sphingosine-1-phosphate	0,23	MAP kinase phosphatase-3	Sphingosine-1-phosphate	67603(Tax:10090)	13609(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY inhibits|nmod|induction inhibits|nsubj|END_ENTITY	Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP_kinase_phosphatase-3 .
23300075	0	MARCH-8	53,60	membrane-associated_RING-CH-8	22,51	MARCH-8	membrane-associated RING-CH-8	220972	220972	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Ubiquitination by the membrane-associated_RING-CH-8 -LRB- MARCH-8 -RRB- ligase controls steady-state cell surface expression of tumor_necrosis_factor-related_apoptosis_inducing_ligand _ -LRB- TRAIL -RRB- _ receptor_1 .
21385572	0	MARCH-I	0,7	KDR	38,41	MARCH-I	KDR	55016	3791	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	MARCH-I expression in cord blood CD34 + KDR + cells .
21937444	0	MARCH10	32,39	Membrane-associated_RING-CH_10	0,30	MARCH10	Membrane-associated RING-CH 10	303596(Tax:10116)	303596(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Membrane-associated_RING-CH_10 -LRB- MARCH10 protein -RRB- is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella .
18410486	0	MARCH7	24,30	USP7	91,95	MARCH7	USP7	64844	7874	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X .
1544410	0	MARCKS	41,47	80_kDa	33,39	MARCKS	80 kDa	17118(Tax:10090)	13139(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Multisite phosphorylation of the 80_kDa -LRB- MARCKS -RRB- protein kinase C substrate in C3H/10T1/2 fibroblasts .
1860846	0	MARCKS	57,63	MACS	71,75	MARCKS	MACS	4082	4082	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- gene -LRB- MACS -RRB- .
1516135	0	MARCKS	33,39	MacMARCKS	0,9	MARCKS	MacMARCKS	100345174(Tax:9986)	100009158(Tax:9986)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	MacMARCKS , a novel member of the MARCKS family of protein_kinase_C substrates .
19302977	0	MARCKS	29,35	MicroRNA-21	0,11	MARCKS	MicroRNA-21	4082	406991	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate_cancer cells .
10679575	0	MARCKS	36,42	calmodulin	80,90	MARCKS	calmodulin	4082	808	Gene	Gene	phosphorylation|nmod|START_ENTITY alter|nsubj|phosphorylation alter|nmod|END_ENTITY	Thrombin-induced phosphorylation of MARCKS does not alter its interactions with calmodulin or actin .
16046479	0	MARCKS	0,6	calmodulin	45,55	MARCKS	calmodulin	4082	808	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MARCKS is a major PKC-dependent regulator of calmodulin targeting in smooth muscle .
7840634	0	MARCKS	55,61	calmodulin	113,123	MARCKS	calmodulin	4082	808	Gene	Gene	responses|dep|START_ENTITY phosphorylation|nsubj|responses phosphorylation|nmod|END_ENTITY	Differential responses of protein_kinase_C substrates -LRB- MARCKS , neuromodulin , and neurogranin -RRB- phosphorylation to calmodulin and S100 .
14507707	0	MARCKS	63,69	myristoylated_alanine-rich_C-kinase_substrate	16,61	MARCKS	myristoylated alanine-rich C-kinase substrate	4082	4082	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Location of the myristoylated_alanine-rich_C-kinase_substrate -LRB- MARCKS -RRB- effector domain in negatively charged phospholipid bicelles .
8216211	0	MARCKS	41,47	myristoylated_alanine-rich_C-kinase_substrate	49,94	MARCKS	myristoylated alanine-rich C-kinase substrate	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|dep|END_ENTITY	Effects of insulin and phorbol_esters on MARCKS -LRB- myristoylated_alanine-rich_C-kinase_substrate -RRB- phosphorylation -LRB- and other parameters of protein kinase C activation -RRB- in rat adipocytes , rat soleus muscle and BC3H-1 myocytes .
10859236	0	MARCKS	66,72	myristoylated_alanine-rich_C_kinase_substrate	19,64	MARCKS	myristoylated alanine-rich C kinase substrate	613548(Tax:9913)	613548(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein is associated with bovine luteal oxytocin exocytosis .
10871043	0	MARCKS	76,82	myristoylated_alanine-rich_C_kinase_substrate	29,74	MARCKS	myristoylated alanine-rich C kinase substrate	4082	4082	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Regulation of the binding of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- related protein to lipid bilayer membranes by calmodulin .
12067241	0	MARCKS	80,86	myristoylated_alanine-rich_C_kinase_substrate	33,78	MARCKS	myristoylated alanine-rich C kinase substrate	4082	4082	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of rho-kinase-induced myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- phosphorylation in human neuronal cells by H-1152 , a novel and specific Rho-kinase inhibitor .
12675922	0	MARCKS	89,95	myristoylated_alanine-rich_C_kinase_substrate	42,87	MARCKS	myristoylated alanine-rich C kinase substrate	17118(Tax:10090)	17118(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression and regulation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- in the hippocampus of C57/BL6J and DBA/2J mice .
12849934	0	MARCKS	89,95	myristoylated_alanine-rich_C_kinase_substrate	42,87	MARCKS	myristoylated alanine-rich C kinase substrate	4082	4082	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression and phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- in postmortem brain of suicide victims with or without depression .
12930725	0	MARCKS	78,84	myristoylated_alanine-rich_C_kinase_substrate	31,76	MARCKS	myristoylated alanine-rich C kinase substrate	613548(Tax:9913)	613548(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Spatiotemporal interactions of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein with the actin cytoskeleton and exocytosis of oxytocin upon prostaglandin_F2alpha stimulation of bovine luteal cells .
1332970	0	MARCKS	75,81	myristoylated_alanine-rich_C_kinase_substrate	28,73	MARCKS	myristoylated alanine-rich C kinase substrate	4082	4082	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Membrane association of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor .
1527003	0	MARCKS	82,88	myristoylated_alanine-rich_C_kinase_substrate	35,80	MARCKS	myristoylated alanine-rich C kinase substrate	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Glucose-induced phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- in isolated rat pancreatic islets .
1860846	0	MARCKS	57,63	myristoylated_alanine-rich_C_kinase_substrate	10,55	MARCKS	myristoylated alanine-rich C kinase substrate	4082	4082	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The human myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- gene -LRB- MACS -RRB- .
20205598	0	MARCKS	61,67	myristoylated_alanine-rich_C_kinase_substrate	14,59	MARCKS	myristoylated alanine-rich C kinase substrate	4082	4082	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Inhibition of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein inhibits ozone-induced airway neutrophilia and inflammation .
7616238	0	MARCKS	66,72	myristoylated_alanine-rich_C_kinase_substrate	19,64	MARCKS	myristoylated alanine-rich C kinase substrate	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- by proline-directed protein kinases and its dephosphorylation .
7768946	0	MARCKS	75,81	myristoylated_alanine-rich_C_kinase_substrate	28,73	MARCKS	myristoylated alanine-rich C kinase substrate	396473(Tax:9031)	396473(Tax:9031)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Membrane association of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein .
7859929	0	MARCKS	119,125	myristoylated_alanine-rich_C_kinase_substrate	72,117	MARCKS	myristoylated alanine-rich C kinase substrate	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Arginine vasopressin -LRB- AVP -RRB- causes the reversible phosphorylation of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein in the ovine anterior pituitary : evidence that MARCKS phosphorylation is associated with adrenocorticotropin -LRB- ACTH -RRB- secretion .
9397959	0	MARCKS	119,125	myristoylated_alanine-rich_C_kinase_substrate	72,117	MARCKS	myristoylated alanine-rich C kinase substrate	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Arginine vasopressin -LRB- AVP -RRB- causes the reversible phosphorylation of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein in the ovine anterior pituitary : evidence that MARCKS phosphorylation is associated with adrenocorticotropin -LRB- ACTH -RRB- secretion .
1335598	0	MARCKS	118,124	myristoylated_alanine_rich_C_kinase_substrate	71,116	MARCKS	myristoylated alanine rich C kinase substrate	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Transforming growth factor-beta -LRB- TGF-b -RRB- induced phosphorylation of the myristoylated_alanine_rich_C_kinase_substrate -LRB- MARCKS -RRB- protein in ovarian granulosa cells is modulated by follicle stimulating hormone -LRB- FSH -RRB- .
23197261	0	MARCO	0,5	TLR2	22,26	MARCO	TLR2	17167(Tax:10090)	24088(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|responses responses|amod|END_ENTITY	MARCO is required for TLR2 - and Nod2-mediated responses to Streptococcus_pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx .
20878136	0	MARK	142,146	mitogen_activated_protein_kinase	108,140	MARK	mitogen activated protein kinase	4139	4139	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	The antiandrogen bicalutamide activates the androgen_receptor -LRB- AR -RRB- with a mutation in codon 741 through the mitogen_activated_protein_kinase -LRB- MARK -RRB- pathway in human prostate_cancer PC3 cells .
16971810	0	MART-1	105,111	CD8	121,124	MART-1	CD8	388015	925	Gene	Gene	immunity|amod|START_ENTITY immunity|compound|END_ENTITY	Dendritic cells loaded with killed allogeneic melanoma cells can induce objective clinical responses and MART-1 specific CD8 + T-cell immunity .
22768350	0	MART-1	58,64	CD8	76,79	MART-1	CD8	2315	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Human macrophages and dendritic cells can equally present MART-1 antigen to CD8 -LRB- + -RRB- T cells after phagocytosis of gamma-irradiated melanoma cells .
9378560	0	MART-1	59,65	CD8	15,18	MART-1	CD8	2315	925	Gene	Gene	Stimulation|dep|START_ENTITY Stimulation|nmod|responses responses|compound|END_ENTITY	Stimulation of CD8 + T cell responses to MAGE-3 and Melan_A / MART-1 by immunization to a polyvalent melanoma vaccine .
9850054	0	MART-1	101,107	CD8	14,17	MART-1	CD8	2315	925	Gene	Gene	gene|compound|START_ENTITY express|dobj|gene engineered|xcomp|express cells|amod|engineered +|nmod|cells +|nsubj|Generation Generation|nmod|+ +|compound|END_ENTITY	Generation of CD8 + and CD4 + T-cell response to dendritic cells genetically engineered to express the MART-1 / Melan-A gene .
9850054	0	MART-1	101,107	Melan-A	108,115	MART-1	Melan-A	2315	2315	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Generation of CD8 + and CD4 + T-cell response to dendritic cells genetically engineered to express the MART-1 / Melan-A gene .
9706977	0	MART1	23,28	melan-A	14,21	MART1	melan-A	2315	2315	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of melan-A -LRB- MART1 -RRB- in benign_melanocytic_nevi and primary cutaneous_malignant_melanoma .
25885414	0	MARVELD2	0,8	DFNB49	10,16	MARVELD2	DFNB49	153562	153562	Gene	Gene	Mutations|compound|START_ENTITY Mutations|appos|END_ENTITY	MARVELD2 -LRB- DFNB49 -RRB- Mutations in the Hearing Impaired Central European_Roma Population - Prevalence , Clinical Impact and the Common Origin .
10781804	0	MASH-1	39,45	Myocyte_enhancer_factor_2C	0,26	MASH-1	Myocyte enhancer factor 2C	17172(Tax:10090)	17260(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Myocyte_enhancer_factor_2C upregulates MASH-1 expression and induces neurogenesis in P19 cells .
17409112	0	MASH1	26,31	Dlx1/2	52,58	MASH1	Dlx1/2	429	1745;1746	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The proneural determinant MASH1 regulates forebrain Dlx1/2 expression through the I12b intergenic enhancer .
24472859	0	MASP-1	6,12	MBL	29,32	MASP-1	MBL	5648	4153	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Serum MASP-1 in complex with MBL activates endothelial cells .
26645987	0	MASP-1	71,77	Prothrombin	45,56	MASP-1	Prothrombin	5648	2147	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	MASP-1 Induced Clotting - The First Model of Prothrombin Activation by MASP-1 .
26046446	0	MASP-2	38,44	MBL-associated_serine_protease_2	4,36	MASP-2	MBL-associated serine protease 2	10747	10747	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Low MBL-associated_serine_protease_2 -LRB- MASP-2 -RRB- levels correlate with urogenital_schistosomiasis in Nigerian children .
17045845	0	MASP-2	138,144	mannan-binding_lectin	4,25	MASP-2	mannan-binding lectin	10747	4153	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	The mannan-binding_lectin pathway and lung_disease in cystic_fibrosis -- disfunction of mannan-binding_lectin-associated serine protease 2 -LRB- MASP-2 -RRB- may be a major modifier .
18456010	0	MASP1	48,53	MBL-associated_serine_protease_1	14,46	MASP1	MBL-associated serine protease 1	5648	5648	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	The action of MBL-associated_serine_protease_1 -LRB- MASP1 -RRB- on factor XIII and fibrinogen .
18439947	0	MASPIN	59,65	mammary_serine_protease_inhibitor	24,57	MASPIN	mammary serine protease inhibitor	5268	5268	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of mammary_serine_protease_inhibitor -LRB- MASPIN -RRB- : is its impact on the prognosis in laryngeal_carcinoma due to a proapoptotic effect ?
9368058	0	MAT1	69,73	CAK	47,50	MAT1	CAK	4331	1022	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	The cyclin-dependent kinase-activating kinase -LRB- CAK -RRB- assembly factor , MAT1 , targets and enhances CAK activity on the POU domains of octamer transcription factors .
12527756	0	MAT1	20,24	MTA1	0,4	MAT1	MTA1	4331	9112	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	MTA1 interacts with MAT1 , a cyclin-dependent kinase-activating kinase complex ring finger factor , and regulates estrogen receptor transactivation functions .
11099469	0	MAT1A	31,36	S-adenosylmethionine	0,20	MAT1A	S-adenosylmethionine	25331(Tax:10116)	25331(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes : a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver .
21460102	0	MAT2A	111,116	HIF-1a	68,74	MAT2A	HIF-1a	4144	3091	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Hypoxia induces genomic DNA demethylation through the activation of HIF-1a and transcriptional upregulation of MAT2A in hepatoma cells .
22542325	0	MAT2A	59,64	methionine_adenosyltransferase_II_alpha	18,57	MAT2A	methionine adenosyltransferase II alpha	4144	4144	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of methionine_adenosyltransferase_II_alpha -LRB- MAT2A -RRB- in gastric_cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene .
23876341	0	MATE1	83,88	OCT2	35,39	MATE1	OCT2	55244	6582	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine .
22722930	0	MATE1	67,72	multidrug_and_toxin_extruder_1	74,104	MATE1	multidrug and toxin extruder 1	55244	55244	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Twelve transmembrane helices form the functional core of mammalian MATE1 -LRB- multidrug_and_toxin_extruder_1 -RRB- protein .
22149660	0	MATE1	54,59	multidrug_and_toxin_extrusion_1	21,52	MATE1	multidrug and toxin extrusion 1	55244	55244	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human multidrug_and_toxin_extrusion_1 -LRB- MATE1 -RRB- transporter with antineoplastic agents .
19542546	0	MATER	0,5	PKCepsilon	30,40	MATER	PKCepsilon	126206	5581	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	MATER protein as substrate of PKCepsilon in human cumulus cells .
17176459	0	MATN1	47,52	matrilin-1	30,40	MATN1	matrilin-1	17180(Tax:10090)	17180(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence of a linkage between matrilin-1 gene -LRB- MATN1 -RRB- and idiopathic_scoliosis .
17044855	0	MATP	48,52	SLC45A2	39,46	MATP	SLC45A2	51151	51151	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Distribution of the F374 allele of the SLC45A2 -LRB- MATP -RRB- gene and founder-haplotype analysis .
17358008	0	MATP	30,34	SLC45A2	36,43	MATP	SLC45A2	51151	51151	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter polymorphisms in the MATP -LRB- SLC45A2 -RRB- gene are associated with normal human skin color variation .
25847972	0	MAVS	0,4	ASC	51,54	MAVS	ASC	57506	29108	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3 .
20161788	0	MAVS	32,36	TRAF5	0,5	MAVS	TRAF5	57506	7188	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	TRAF5 is a downstream target of MAVS in antiviral innate immune signaling .
23545497	0	MAVS	90,94	UBXN1	0,5	MAVS	UBXN1	57506	51035	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS .
24285545	0	MAVS	49,53	mitochondrial_antiviral_signaling	14,47	MAVS	mitochondrial antiviral signaling	57506	57506	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Regulation of mitochondrial_antiviral_signaling -LRB- MAVS -RRB- expression and signaling by the mitochondria-associated_endoplasmic_reticulum_membrane -LRB- MAM -RRB- protein Gp78 .
26919985	0	MAX2	14,18	SCARECROW	25,34	MAX2	SCARECROW	818862(Tax:3702)	824589(Tax:3702)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Expression of MAX2 under SCARECROW promoter enhances the strigolactone/MAX2 dependent response of Arabidopsis roots to low-phosphate conditions .
16491076	0	MAZR	103,107	CD8	23,26	MAZR	CD8	23598	925	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR .
16491076	0	MAZR	103,107	Cd8	42,45	MAZR	Cd8	23598	925	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|recruitment recruitment|amod|END_ENTITY	Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR .
18308860	0	MAdCAM-1	83,91	CCL25	0,5	MAdCAM-1	CCL25	8174	6370	Gene	Gene	promote|nmod|START_ENTITY promote|nsubj|END_ENTITY	CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow .
12003644	0	MAdCAM-1	46,54	TNF-a	18,23	MAdCAM-1	TNF-a	8174	7124	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB .
11481030	0	MAdCAM-1	30,38	TNF-alpha	0,9	MAdCAM-1	TNF-alpha	8174	7124	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous , not endogenous nitric_oxide .
10627468	0	MAdCAM-1	30,38	VCAM-1	0,6	MAdCAM-1	VCAM-1	8174	7412	Gene	Gene	effective|nmod|START_ENTITY effective|nsubj|END_ENTITY	VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow .
15030510	0	MAdCAM-1	126,134	colitis	196,203	MAdCAM-1	LTbetaR	17123(Tax:10090)	17000(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Blocking lymphotoxin-beta_receptor activation diminishes inflammation via reduced mucosal_addressin_cell_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- expression and leucocyte margination in chronic DSS-induced colitis .
15030510	0	MAdCAM-1	126,134	mucosal_addressin_cell_adhesion_molecule-1	82,124	MAdCAM-1	mucosal addressin cell adhesion molecule-1	17123(Tax:10090)	17123(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Blocking lymphotoxin-beta_receptor activation diminishes inflammation via reduced mucosal_addressin_cell_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- expression and leucocyte margination in chronic DSS-induced colitis .
17202440	0	MAdCAM-1	89,97	mucosal_addressin_cellular_adhesion_molecule-1	41,87	MAdCAM-1	mucosal addressin cellular adhesion molecule-1	17123(Tax:10090)	17123(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Parenteral nutrition and fasting reduces mucosal_addressin_cellular_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- mRNA in Peyer 's patches of mice .
15117939	0	MAp19	74,79	mannan-binding_lectin	111,132	MAp19	mannan-binding lectin	10747	4153	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The X-ray structure of human mannan-binding_lectin-associated_protein_19 -LRB- MAp19 -RRB- and its interaction site with mannan-binding_lectin and L-ficolin .
2080916	0	MB-10	70,75	L-asparaginase	22,36	MB-10	L-asparaginase	11536(Tax:10090)	66514(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Antitumor activity of L-asparaginase from Cylindrocarpon obtusisporum MB-10 and its effect on the immune system .
3890265	0	MB1	121,124	DR5	115,118	MB1	DR5	5693	8795	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Immunochemical analysis of class II molecules expressed by a human B cell line with the unusual class II genotype , DR5 + , MB1 + , -LRB- MB3 - -RRB- , MT2 + .
26980696	0	MBD1	0,4	KEAP1	35,40	MBD1	KEAP1	4152	9817	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MBD1 is an epigenetic regulator of KEAP1 in pancreatic_cancer .
18842587	0	MBD1-containing_chromatin-associated_factor_1	75,120	SUMO-3	130,136	MBD1-containing chromatin-associated factor 1	SUMO-3	55729	6612	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Structure of the small ubiquitin-like modifier -LRB- SUMO -RRB- - interacting motif of MBD1-containing_chromatin-associated_factor_1 bound to SUMO-3 .
23071088	0	MBD2	0,4	CHD4	29,33	MBD2	CHD4	8932	1108	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2 / NuRD complexes .
19661918	0	MBD2	120,124	FAK	99,102	MBD2	FAK	17191(Tax:10090)	14083(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nsubj|Regulation Regulation|nmod|remodelling remodelling|nmod|differentiation differentiation|nmod|END_ENTITY	Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2 .
19949307	0	MBD2	21,25	FAK	0,3	MBD2	FAK	8932	5747	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	FAK interaction with MBD2 : A link from cell adhesion to nuclear chromatin remodeling ?
24939308	0	MBD2	47,51	Methyl-CpG_binding_domain_protein_2	10,45	MBD2	Methyl-CpG binding domain protein 2	17191(Tax:10090)	17191(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of Methyl-CpG_binding_domain_protein_2 -LRB- MBD2 -RRB- on AMD-like lesions in ApoE-deficient mice .
15516265	0	MBD2/3	42,48	p55	85,88	MBD2/3	p55	41151(Tax:7227)	41836(Tax:7227)	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2 .
15701600	0	MBD3	22,26	MBD3L2	0,6	MBD3	MBD3L2	53615	125997	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing .
12504854	0	MBD3L1	0,6	MBD3L1	117,123	MBD3L1	MBD3L1	85509	85509	Gene	Gene	START_ENTITY|dep|characterization characterization|nmod|END_ENTITY	MBD3L1 and MBD3L2 , two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3 : characterization of MBD3L1 as a testis-specific transcriptional repressor .
12504854	0	MBD3L1	117,123	MBD3L1	0,6	MBD3L1	MBD3L1	85509	85509	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|dep|characterization	MBD3L1 and MBD3L2 , two new proteins homologous to the methyl-CpG-binding proteins MBD2 and MBD3 : characterization of MBD3L1 as a testis-specific transcriptional repressor .
15701600	0	MBD3L2	0,6	MBD3	22,26	MBD3L2	MBD3	125997	53615	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing .
24434851	0	MBD4	0,4	DNMT1	21,26	MBD4	DNMT1	8930	1786	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress .
11267993	0	MBD4	14,18	MED1	8,12	MBD4	MED1	8930	5469	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Role of MED1 -LRB- MBD4 -RRB- Gene in DNA repair and human cancer .
25358258	0	MBD4	0,4	USP7	33,37	MBD4	USP7	8930	7874	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	MBD4 Interacts with and Recruits USP7 to heterochromatic foci .
24750026	0	MBD5	0,4	KAT2A	93,98	MBD5	KAT2A	109241(Tax:10090)	14534(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 through KAT2A in mice .
23052207	0	MBD6	0,4	Oct4	27,31	MBD6	Oct4	114785	5460	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MBD6 is a direct target of Oct4 and controls the stemness and differentiation of adipose tissue-derived stem cells .
12506002	0	MBF1	11,15	Tracheae_Defective	38,56	MBF1	Tracheae Defective	39842(Tax:7227)	37734(Tax:7227)	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	Drosophila MBF1 is a co-activator for Tracheae_Defective and contributes to the formation of tracheal and nervous systems .
18166085	0	MBII-85	16,23	snoRNA	24,30	MBII-85	snoRNA	100616072	85389	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal_growth_retardation .
10878362	0	MBL	46,49	C1q	15,18	MBL	C1q	4153	712	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C1q and mannan-binding_lectin -LRB- MBL -RRB- with C1r , C1s , MBL-associated_serine_proteases_1_and_2 , and the MBL-associated protein MAp19 .
10878362	0	MBL	46,49	C1r	56,59	MBL	C1r	4153	715	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C1q and mannan-binding_lectin -LRB- MBL -RRB- with C1r , C1s , MBL-associated_serine_proteases_1_and_2 , and the MBL-associated protein MAp19 .
21591983	0	MBL	64,67	IFN-gamma	53,62	MBL	IFN-gamma	50639	3458	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
21591983	0	MBL	64,67	IL-10	40,45	MBL	IL-10	50639	3586	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
21591983	0	MBL	64,67	IL-6	47,51	MBL	IL-6	50639	3569	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
24472859	0	MBL	29,32	MASP-1	6,12	MBL	MASP-1	4153	5648	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Serum MASP-1 in complex with MBL activates endothelial cells .
12472676	0	MBL	61,64	MBL	76,79	MBL	MBL	4153	4153	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Analysis of the relationship between mannose-binding_lectin -LRB- MBL -RRB- genotype , MBL levels and function in an Australian blood donor population .
12472676	0	MBL	76,79	MBL	61,64	MBL	MBL	4153	4153	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Analysis of the relationship between mannose-binding_lectin -LRB- MBL -RRB- genotype , MBL levels and function in an Australian blood donor population .
21088049	0	MBL	51,54	MBL	71,74	MBL	MBL	4153	4153	Gene	Gene	Association|appos|START_ENTITY END_ENTITY|nsubj|Association	Association of genetic variants of mannan-binding -LRB- MBL -RRB- lectin-2 gene , MBL levels and function in ulcerative_colitis and Crohn 's _ disease .
21088049	0	MBL	71,74	MBL	51,54	MBL	MBL	4153	4153	Gene	Gene	START_ENTITY|nsubj|Association Association|appos|END_ENTITY	Association of genetic variants of mannan-binding -LRB- MBL -RRB- lectin-2 gene , MBL levels and function in ulcerative_colitis and Crohn 's _ disease .
24134411	0	MBL	123,126	MBL2	91,95	MBL	MBL2	4153	4153	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Characterization of mannose-binding_lectin -LRB- MBL -RRB- variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels .
11607788	0	MBL	23,26	Mannan-binding_lectin	0,21	MBL	Mannan-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mannan-binding_lectin -LRB- MBL -RRB- gene polymorphisms in ulcerative_colitis and Crohn 's _ disease .
18368489	0	MBL	23,26	Mannan-binding_lectin	0,21	MBL	Mannan-binding lectin	4153	4153	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Mannan-binding_lectin -LRB- MBL -RRB- polymorphism and gastric_cancer risk in Japanese population .
21591983	0	MBL	64,67	TGF-beta_1	28,38	MBL	TGF-beta 1	50639	7040	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
21591983	0	MBL	64,67	TNF-alpha	17,26	MBL	TNF-alpha	50639	7124	Gene	Gene	GPIA|appos|START_ENTITY GPIA|compound|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
10022380	0	MBL	68,71	mannan-binding_lectin	45,66	MBL	mannan-binding lectin	4153	4153	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	High-level and effective production of human mannan-binding_lectin -LRB- MBL -RRB- in Chinese_hamster_ovary -LRB- CHO -RRB- cells .
10915847	0	MBL	96,99	mannan-binding_lectin	73,94	MBL	mannan-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of structural gene mutations and promoter polymorphisms in the mannan-binding_lectin -LRB- MBL -RRB- gene by polymerase chain reaction with sequence-specific primers .
16487239	0	MBL	54,57	mannan-binding_lectin	19,40	MBL	mannan-binding lectin	4153	4153	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	Elevated levels of mannan-binding_lectin -LSB- corrected -RSB- -LRB- MBL -RRB- and eosinophilia in patients of bronchial_asthma with allergic_rhinitis and allergic_bronchopulmonary_aspergillosis associate with a novel intronic polymorphism in MBL .
12472676	0	MBL	61,64	mannose-binding_lectin	37,59	MBL	mannose-binding lectin	4153	4153	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Analysis of the relationship between mannose-binding_lectin -LRB- MBL -RRB- genotype , MBL levels and function in an Australian blood donor population .
12472676	0	MBL	76,79	mannose-binding_lectin	37,59	MBL	mannose-binding lectin	4153	4153	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Analysis of the relationship between mannose-binding_lectin -LRB- MBL -RRB- genotype , MBL levels and function in an Australian blood donor population .
16517152	0	MBL	36,39	mannose-binding_lectin	12,34	MBL	mannose-binding lectin	4153	4153	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of mannose-binding_lectin -LRB- MBL -RRB- in paediatric oncology patients with febrile_neutropenia .
17711490	0	MBL	28,31	mannose-binding_lectin	4,26	MBL	mannose-binding lectin	4153	4153	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Low mannose-binding_lectin -LRB- MBL -RRB- levels in neonates with pneumonia and sepsis .
21333363	0	MBL	41,44	mannose-binding_lectin	17,39	MBL	mannose-binding lectin	100302094(Tax:9940)	100302094(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in mannose-binding_lectin -LRB- MBL -RRB- gene and their association with MBL protein levels in serum in the Hu sheep .
21681178	0	MBL	30,33	mannose-binding_lectin	6,28	MBL	mannose-binding lectin	4153	4153	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Serum mannose-binding_lectin -LRB- MBL -RRB- gene polymorphism and low MBL levels are associated with neonatal_sepsis and pneumonia .
24134411	0	MBL	44,47	mannose-binding_lectin	20,42	MBL	mannose-binding lectin	4153	4153	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of mannose-binding_lectin -LRB- MBL -RRB- variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels .
25105751	0	MBL	28,31	mannose-binding_lectin	4,26	MBL	mannose-binding lectin	4153	4153	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Low mannose-binding_lectin -LRB- MBL -RRB- levels and MBL genetic polymorphisms associated with the risk of neonatal_sepsis : An updated meta-analysis .
26188838	0	MBL	45,48	mannose-binding_lectin	21,43	MBL	mannose-binding lectin	4153	4153	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human mannose-binding_lectin -LRB- MBL -RRB- with Yersinia_enterocolitica lipopolysaccharide .
14994386	0	MBL	45,48	mannose_binding_lectin	21,43	MBL	mannose binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the mannose_binding_lectin -LRB- MBL -RRB- gene are not associated with radiographic erosions in rheumatoid or inflammatory_polyarthritis .
23891525	0	MBL	71,74	metallo-b-lactamase	50,69	MBL	metallo-b-lactamase	17195(Tax:10090)	17195(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	In vivo efficacy of biapenem with ME1071 , a novel metallo-b-lactamase -LRB- MBL -RRB- inhibitor , in a murine model mimicking ventilator-associated_pneumonia caused by MBL-producing Pseudomonas_aeruginosa .
20499118	0	MBL-2	29,34	Mannose-binding_lectin	0,22	MBL-2	Mannose-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mannose-binding_lectin gene -LRB- MBL-2 -RRB- polymorphism in oral_lichen_planus .
16040048	0	MBL-2	98,103	mannose_binding_lectin	74,96	MBL-2	mannose binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	PCR-RFLP genotyping for exon 1 and promoter region mutations of the human mannose_binding_lectin -LRB- MBL-2 -RRB- gene .
18456010	0	MBL-associated_serine_protease_1	14,46	MASP1	48,53	MBL-associated serine protease 1	MASP1	5648	5648	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	The action of MBL-associated_serine_protease_1 -LRB- MASP1 -RRB- on factor XIII and fibrinogen .
17177967	0	MBL-associated_serine_protease_1	128,160	mannan-binding_lectin	100,121	MBL-associated serine protease 1	mannan-binding lectin	5648	4153	Gene	Gene	complex|dep|START_ENTITY END_ENTITY|dep|complex	Severe fibrosis in hepatitis_C_virus-infected patients is associated with increased activity of the mannan-binding_lectin -LRB- MBL -RRB- / MBL-associated_serine_protease_1 -LRB- MASP-1 -RRB- complex .
26046446	0	MBL-associated_serine_protease_2	4,36	MASP-2	38,44	MBL-associated serine protease 2	MASP-2	10747	10747	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Low MBL-associated_serine_protease_2 -LRB- MASP-2 -RRB- levels correlate with urogenital_schistosomiasis in Nigerian children .
21274526	0	MBL1	66,70	mannose-binding_lectin_1	40,64	MBL1	mannose-binding lectin 1	492276(Tax:9823)	492276(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural gene variants in the porcine mannose-binding_lectin_1 -LRB- MBL1 -RRB- gene are associated with low serum MBL-A concentrations .
23114911	0	MBL1	88,92	somatic_cell_score	59,77	MBL1	somatic cell score	497014(Tax:9913)	100532666	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	SNPs identification and its correlation analysis with milk somatic_cell_score in bovine MBL1 gene .
24134411	0	MBL2	91,95	MBL	123,126	MBL2	MBL	4153	4153	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Characterization of mannose-binding_lectin -LRB- MBL -RRB- variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels .
21510992	0	MBL2	29,33	Mannose_binding_lectin	0,22	MBL2	Mannose binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mannose_binding_lectin gene -LRB- MBL2 -RRB- functional polymorphisms are associated with systemic_lupus_erythematosus in southern Brazilians .
19416237	0	MBL2	90,94	mannan-binding_lectin	67,88	MBL2	mannan-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of genetic association of promoter and structural variants of mannan-binding_lectin -LRB- MBL2 -RRB- gene with susceptibility to generalized vitiligo .
15306844	0	MBL2	49,53	mannose-binding_lectin	25,47	MBL2	mannose-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence analysis of the mannose-binding_lectin -LRB- MBL2 -RRB- gene reveals a high degree of heterozygosity with evidence of selection .
18637753	0	MBL2	47,51	mannose-binding_lectin	23,45	MBL2	mannose-binding lectin	4153	4153	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Detrimental effects of mannose-binding_lectin -LRB- MBL2 -RRB- promoter genotype XA/XA on HIV-1 vertical transmission and AIDS progression .
22131319	0	MBL2	77,81	mannose-binding_lectin	48,70	MBL2	mannose-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Study of the effect of DNA polymorphisms in the mannose-binding_lectin gene -LRB- MBL2 -RRB- on disease severity in Slovak cystic_fibrosis patients .
25725598	0	MBL2	69,73	mannose-binding_lectin	40,62	MBL2	mannose-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The presence of variant genotype of the mannose-binding_lectin gene -LRB- MBL2 -RRB- is not associated with increased restenosis rate in carotid surgery .
17380431	0	MBL2	78,82	mannose-binding_lectin_2	52,76	MBL2	mannose-binding lectin 2	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between genetic variants in the mannose-binding_lectin_2 -LRB- MBL2 -RRB- gene and HPV_infection .
20712490	0	MBL2	67,71	mannose-binding_lectin_2	41,65	MBL2	mannose-binding lectin 2	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	High frequency of variant alleles of the mannose-binding_lectin_2 -LRB- MBL2 -RRB- gene are associated with patients infected by hepatitis_B_virus .
25211016	0	MBNL1	23,28	RBFOX1	0,6	MBNL1	RBFOX1	56758(Tax:10090)	268859(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	RBFOX1 cooperates with MBNL1 to control splicing in muscle , including events altered in myotonic_dystrophy type 1 .
18335541	0	MBNL1	0,5	YB-1	22,26	MBNL1	YB-1	4154	4904	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	MBNL1 associates with YB-1 in cytoplasmic stress granules .
22347229	0	MBP	68,71	Mannose_Binding_Protein	43,66	MBP	Mannose Binding Protein	4155	4155	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Molecular Identification and Sequencing of Mannose_Binding_Protein -LRB- MBP -RRB- Gene of Acanthamoeba palestinensis .
18616943	0	MBP	120,123	U24	19,22	MBP	U24	4155	26820	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of U24 from Human_Herpes_Virus_type_6 -LRB- HHV-6 -RRB- and its potential role in mimicking myelin_basic_protein -LRB- MBP -RRB- in multiple_sclerosis .
9720214	0	MBP	60,63	mannan-binding_protein	36,58	MBP	mannan-binding protein	4155	4155	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of truncated human mannan-binding_protein -LRB- MBP -RRB- expressed in Escherichia_coli .
8125525	0	MBP	52,55	mannose-binding_protein	27,50	MBP	mannose-binding protein	4155	4155	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Perinatal changes in serum mannose-binding_protein -LRB- MBP -RRB- levels .
11122251	0	MBP	36,39	myelin_basic_protein	14,34	MBP	myelin basic protein	4155	4155	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of myelin_basic_protein -LRB- MBP -RRB- epitopes in human non-neural cells revealed by two anti-MBP IgM monoclonal antibodies .
1697235	0	MBP	32,35	myelin_basic_protein	10,30	MBP	myelin basic protein	100344447(Tax:9986)	100344447(Tax:9986)	Gene	Gene	Assay|appos|START_ENTITY Assay|nmod|END_ENTITY	-LSB- Assay of myelin_basic_protein -LRB- MBP -RRB- antibody in the cerebrospinal fluid and serum of rabbits with experimental_allergic_encephalomyelitis -LRB- EAE -RRB- before and after sensitization -RSB- .
19556180	0	MBP	36,39	myelin_basic_protein	14,34	MBP	myelin basic protein	24547(Tax:10116)	24547(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of myelin_basic_protein -LRB- MBP -RRB- on the bioelectric activity of spinal cord and cerebellar neurones .
2414074	0	MBP	53,56	myelin_basic_protein	26,46	MBP	myelin basic protein	4155	4155	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization of the human myelin_basic_protein gene -LRB- MBP -RRB- to region 18q22 -- qter by in situ hybridization .
8621121	0	MBP	117,120	myelin_basic_protein	95,115	MBP	myelin basic protein	4155	4155	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	PCR typing of DNA fragments of the two short tandem repeat -LRB- STR -RRB- systems upstream of the human myelin_basic_protein -LRB- MBP -RRB- gene in Danes and Greenland Eskimos .
9345452	0	MBP	100,103	myelin_basic_protein	78,98	MBP	myelin basic protein	4155	4155	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	PCR typing of two short tandem repeat -LRB- STR -RRB- structures upstreams of the human myelin_basic_protein -LRB- MBP -RRB- gene ; the genetic susceptibility in multiple_sclerosis and monosymptomatic idiopathic optic_neuritis in Danes .
19846662	0	MBP-1	0,5	COX-2	71,76	MBP-1	COX-2	4153	5743	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	MBP-1 suppresses growth and metastasis of gastric_cancer cells through COX-2 .
23421821	0	MBP-1	50,55	ERBB2	36,41	MBP-1	ERBB2	2023	2064	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	Negative transcriptional control of ERBB2 gene by MBP-1 and HDAC1 : diagnostic implications in breast_cancer .
10403782	0	MBP-1	0,5	histone_deacetylase	33,52	MBP-1	histone deacetylase	4153	9734	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	MBP-1 physically associates with histone_deacetylase for transcriptional repression .
20657750	0	MBP-1	0,5	miR-29b	18,25	MBP-1	miR-29b	30008	407024	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	MBP-1 upregulates miR-29b that represses Mcl-1 , collagens , and matrix-metalloproteinase-2 in prostate_cancer cells .
23224873	0	MC1R	105,109	NCKX5	0,5	MC1R	NCKX5	4157	283652	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NCKX5 , a natural regulator of human skin colour variation , regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes .
21733131	0	MC1R	16,20	UBE3A	0,5	MC1R	UBE3A	4157	7337	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	UBE3A regulates MC1R expression : a link to hypopigmentation in Angelman_syndrome .
12503610	0	MC1R	50,54	melanocortin-1_receptor	25,48	MC1R	melanocortin-1 receptor	17199(Tax:10090)	17199(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Homologous regulation of melanocortin-1_receptor -LRB- MC1R -RRB- expression in melanoma_tumor cells in vivo .
23915680	0	MC1R	155,159	melanocortin-1_receptor	125,148	MC1R	melanocortin-1 receptor	106145744	106145744	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Color differences among feral pigeons -LRB- Columba_livia -RRB- are not attributable to sequence variation in the coding region of the melanocortin-1_receptor gene -LRB- MC1R -RRB- .
11030758	0	MC1R	52,56	melanocortin_1_receptor	27,50	MC1R	melanocortin 1 receptor	4157	4157	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pleiotropic effects of the melanocortin_1_receptor -LRB- MC1R -RRB- gene on human pigmentation .
14961558	0	MC1R	54,58	melanocortin_1_receptor	29,52	MC1R	melanocortin 1 receptor	4157	4157	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of four novel melanocortin_1_receptor -LRB- MC1R -RRB- gene variants in a Mediterranean population .
15963603	0	MC1R	46,50	melanocortin_1_receptor	21,44	MC1R	melanocortin 1 receptor	4157	4157	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	The relation between melanocortin_1_receptor -LRB- MC1R -RRB- variation and the generation of phenotypic diversity in the cutaneous response to ultraviolet radiation .
16978179	0	MC1R	42,46	melanocortin_1_receptor	17,40	MC1R	melanocortin 1 receptor	100340038(Tax:9986)	100340038(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the melanocortin_1_receptor -LRB- MC1R -RRB- gene are associated with coat colours in the domestic_rabbit -LRB- Oryctolagus_cuniculus -RRB- .
18717860	0	MC1R	54,58	melanocortin_1_receptor	29,52	MC1R	melanocortin 1 receptor	4157	4157	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Main pigmentary features and melanocortin_1_receptor -LRB- MC1R -RRB- gene polymorphisms in the population of the Canary Islands .
19706191	0	MC1R	60,64	melanocortin_1_receptor	35,58	MC1R	melanocortin 1 receptor	106503093	106503093	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Missense and nonsense mutations in melanocortin_1_receptor -LRB- MC1R -RRB- gene of different goat breeds : association with red and black coat colour phenotypes but with unexpected evidences .
20594318	0	MC1R	69,73	melanocortin_1_receptor	44,67	MC1R	melanocortin 1 receptor	100340038(Tax:9986)	100340038(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A composite six bp in-frame deletion in the melanocortin_1_receptor -LRB- MC1R -RRB- gene is associated with the Japanese brindling coat colour in rabbits -LRB- Oryctolagus_cuniculus -RRB- .
20634512	0	MC1R	44,48	melanocortin_1_receptor	19,42	MC1R	melanocortin 1 receptor	100542545	100542545	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variability of the melanocortin_1_receptor -LRB- MC1R -RRB- gene explains the segregation of the bronze locus in turkey -LRB- Meleagris_gallopavo -RRB- .
21214968	0	MC1R	27,31	melanocortin_1_receptor	2,25	MC1R	melanocortin 1 receptor	102099064	102099064	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	A melanocortin_1_receptor -LRB- MC1R -RRB- gene polymorphism is useful for authentication of Massese sheep dairy products .
22011200	0	MC1R	95,99	melanocortin_1_receptor	70,93	MC1R	melanocortin 1 receptor	4157	4157	Gene	Gene	ligand|appos|START_ENTITY ligand|amod|END_ENTITY	Development of melanoma-targeted polymer micelles by conjugation of a melanocortin_1_receptor -LRB- MC1R -RRB- specific ligand .
24830563	0	MC1R	65,69	melanocortin_1_receptor	40,63	MC1R	melanocortin 1 receptor	427562(Tax:9031)	427562(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of exonic variants within the melanocortin_1_receptor -LRB- MC1R -RRB- gene in Black Silky , White Leghorn and Golden duckwing Araucana chicken .
12018414	0	MC1R	76,80	melanocortin_receptor_1	51,74	MC1R	melanocortin receptor 1	281298(Tax:9913)	281298(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Holstein 's milk detection in cheeses inferred from melanocortin_receptor_1 -LRB- MC1R -RRB- gene polymorphism .
14669512	0	MC1R	56,60	melanocortin_receptor_1	32,55	MC1R	melanocortin receptor 1	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Studies of the relationship of melanocortin_receptor_1 -LRB- MC1R -RRB- gene with coat color phenotype in pigs -RSB- .
15524286	0	MC1R	68,72	melanocortin_receptor_1	43,66	MC1R	melanocortin receptor 1	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Single nucleotide polymorphism analysis on melanocortin_receptor_1 -LRB- MC1R -RRB- of Chinese native pig .
17369176	0	MC1R	51,55	melanocortin_receptor_1	26,49	MC1R	melanocortin receptor 1	281298(Tax:9913)	281298(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Relationship between the melanocortin_receptor_1 -LRB- MC1R -RRB- gene and the coat color phenotype in cattle -RSB- .
17884687	0	MC1R	39,43	melanocortin_receptor_1	14,37	MC1R	melanocortin receptor 1	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variations of melanocortin_receptor_1 -LRB- MC1R -RRB- gene in three pig breeds .
26431999	0	MC1R	98,102	melanocortin_receptor_1	73,96	MC1R	melanocortin receptor 1	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of genetic diversity and selection at the coding region of the melanocortin_receptor_1 -LRB- MC1R -RRB- gene in Tibetan pigs and Landrace pigs .
18388300	0	MC1r	56,60	alpha-MSH	16,25	MC1r	alpha-MSH	17199(Tax:10090)	18976(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264 .7 macrophages .
17712720	0	MC2-R	20,25	CREB	45,49	MC2-R	CREB	4158	1385	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of human MC2-R gene expression by CREB , CREM , and ICER in the adrenocortical cell line Y1 .
17456795	0	MC2R	92,96	melanocortin-2_receptor	67,90	MC2R	melanocortin-2 receptor	4158	4158	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	Differential regulation of the human adrenocorticotropin_receptor -LSB- melanocortin-2_receptor -LRB- MC2R -RRB- -RSB- by human MC2R_accessory_protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells .
23724142	0	MC2R	81,85	melanocortin_2_receptor	56,79	MC2R	melanocortin 2 receptor	4158	4158	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization and functional regulation of melanocortin_2_receptor -LRB- MC2R -RRB- in the sea bass .
20962024	0	MC2R	51,55	melanocortin_receptor_2	26,49	MC2R	melanocortin receptor 2	4158	4158	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Loss of the C terminus of melanocortin_receptor_2 -LRB- MC2R -RRB- results in impaired cell surface expression and ACTH insensitivity .
18359160	0	MC2R	66,70	melanocortin_receptor_type_2	36,64	MC2R	melanocortin receptor type 2	4158	4158	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of polymorphisms in the melanocortin_receptor_type_2 -LRB- MC2R , ACTH_receptor -RRB- gene with heroin_addiction .
23201148	0	MC2_receptor	115,127	hormone/receptor	65,81	MC2 receptor	hormone/receptor	4158	3164	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Using the human melanocortin-2 receptor as a model for analyzing hormone/receptor interactions between a mammalian MC2_receptor and ACTH -LRB- 1-24 -RRB- .
18528843	0	MC3	97,100	thioredoxin-like_2	35,53	MC3	thioredoxin-like 2	4159	347736	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and distribution of thioredoxin-like_2 as the antigen for the monoclonal antibody MC3 specific to colorectal_cancer .
20882712	0	MC3R	42,46	melanocortin-3_receptor	17,40	MC3R	melanocortin-3 receptor	4159	4159	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the melanocortin-3_receptor -LRB- MC3R -RRB- gene : Impact on human obesity or adiposity .
11889220	0	MC3R	38,42	melanocortin_3_receptor	8,31	MC3R	melanocortin 3 receptor	4159	4159	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A novel melanocortin_3_receptor gene -LRB- MC3R -RRB- mutation associated with severe obesity .
21695122	0	MC3R	50,54	melanocortin_3_receptor	20,43	MC3R	melanocortin 3 receptor	4159	4159	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic variants of melanocortin_3_receptor gene -LRB- MC3R -RRB- and weight_loss in obesity : a randomised trial of hypo-energetic high - versus low-fat diets .
25501231	0	MC4R	25,29	FTO	20,23	MC4R	FTO	4160	79068	Gene	Gene	SLC30A8|appos|START_ENTITY SLC30A8|compound|END_ENTITY	Association between FTO , MC4R , SLC30A8 , and KCNQ1 gene variants and type 2 diabetes in Saudi population .
19817504	0	MC4R	38,42	IL-6	48,52	MC4R	IL-6	25635(Tax:10116)	24498(Tax:10116)	Gene	Gene	levels|nummod|START_ENTITY levels|compound|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
16520310	0	MC4R	40,44	IMF_and_BF	75,85	MC4R	IMF and BF	397359(Tax:9823)	100326761(Tax:9823)	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	-LSB- Distributions of polymorphism of ADD1 , MC4R , H-FABP gene , associated with IMF_and_BF in 3 populations in pig -RSB- .
26788538	0	MC4R	49,53	Melanocortin_4_receptor	24,47	MC4R	Melanocortin 4 receptor	4160	4160	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic variants of the Melanocortin_4_receptor -LRB- MC4R -RRB- gene in a South African study group .
19817504	0	MC4R	38,42	NPY	27,30	MC4R	NPY	25635(Tax:10116)	24604(Tax:10116)	Gene	Gene	levels|nummod|START_ENTITY levels|compound|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
10656927	0	MC4R	59,63	melanocortin-4_receptor	34,57	MC4R	melanocortin-4 receptor	4160	4160	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A missense variant of the porcine melanocortin-4_receptor -LRB- MC4R -RRB- gene is associated with fatness , growth , and feed intake traits .
15533382	0	MC4R	52,56	melanocortin-4_receptor	27,50	MC4R	melanocortin-4 receptor	4160	4160	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of the melanocortin-4_receptor -LRB- MC4R -RRB- gene in children with premature_pubarche and adolescent girls with hyperandrogenism .
16441297	0	MC4R	73,77	melanocortin-4_receptor	48,71	MC4R	melanocortin-4 receptor	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An effect of a missense mutation in the porcine melanocortin-4_receptor -LRB- MC4R -RRB- gene on production traits in Polish pig breeds is doubtful .
17286227	0	MC4R	69,73	melanocortin-4_receptor	39,62	MC4R	melanocortin-4 receptor	4160	4160	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	A novel non-synonymous mutation in the melanocortin-4_receptor gene -LRB- MC4R -RRB- in a 2-year-old Austrian girl with extreme obesity .
17306938	0	MC4R	45,49	melanocortin-4_receptor	51,74	MC4R	melanocortin-4 receptor	483961(Tax:9615)	483961(Tax:9615)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Polymorphism and chromosomal location of the MC4R -LRB- melanocortin-4_receptor -RRB- gene in the dog and red fox .
17312994	0	MC4R	72,76	melanocortin-4_receptor	47,70	MC4R	melanocortin-4 receptor	428485(Tax:9031)	428485(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The single nucleotide polymorphisms of chicken melanocortin-4_receptor -LRB- MC4R -RRB- gene and their association analysis with carcass traits .
20374902	0	MC4R	44,48	melanocortin-4_receptor	19,42	MC4R	melanocortin-4 receptor	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of the melanocortin-4_receptor -LRB- MC4R -RRB- with feed intake , growth , fatness and carcass composition in pigs raised in Poland .
22062063	0	MC4R	94,98	melanocortin-4_receptor	69,92	MC4R	melanocortin-4 receptor	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Allelic incidence in several pig breeds of a missense variant of pig melanocortin-4_receptor -LRB- MC4R -RRB- gene associated with carcass and productive traits ; its relation to IGF2 genotype .
22444853	0	MC4R	73,77	melanocortin-4_receptor	47,70	MC4R	melanocortin-4 receptor	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Asp298Asn missense mutation in the porcine melanocortin-4_receptor -LRB- MC4R -RRB- gene can be used to affect growth and carcass traits without an effect on meat quality .
16420261	0	MC4R	42,46	melanocortin_4_receptor	17,40	MC4R	melanocortin 4 receptor	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association of a melanocortin_4_receptor -LRB- MC4R -RRB- polymorphism with performance traits in Lithuanian White pigs .
16879346	0	MC4R	51,55	melanocortin_4_receptor	26,49	MC4R	melanocortin 4 receptor	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of the porcine melanocortin_4_receptor -LRB- MC4R -RRB- gene as a positional candidate for a fatness_QTL in a cross between Landrace and Hampshire .
19301229	0	MC4R	42,46	melanocortin_4_receptor	17,40	MC4R	melanocortin 4 receptor	4160	4160	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the melanocortin_4_receptor -LRB- MC4R -RRB- gene in obese patients in Norway .
20820905	0	MC4R	50,54	melanocortin_4_receptor	25,48	MC4R	melanocortin 4 receptor	4160	4160	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic diversity of the melanocortin_4_receptor -LRB- MC4R -RRB- gene and its association with slaughter traits in the Landes goose .
23124548	0	MC4R	55,59	melanocortin_4_receptor	25,48	MC4R	melanocortin 4 receptor	4160	4160	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Selected variants of the melanocortin_4_receptor gene -LRB- MC4R -RRB- do not confer susceptibility to female pattern hair loss .
23947663	0	MC4R	59,63	melanocortin_4_receptor	34,57	MC4R	melanocortin 4 receptor	100355375(Tax:9986)	100355375(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A missense mutation in the rabbit melanocortin_4_receptor -LRB- MC4R -RRB- gene is associated with finishing weight in a meat rabbit line .
25103139	0	MC4R	71,75	melanocortin_4_receptor	41,64	MC4R	melanocortin 4 receptor	4160	4160	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variation in and near the melanocortin_4_receptor gene -LRB- MC4R -RRB- is associated with body mass index in American Indian adults and children .
10687856	0	MC5-R	54,59	melanocortin_receptor-5	29,52	MC5-R	melanocortin receptor-5	507987(Tax:9913)	507987(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of melanocortin_receptor-5 -LRB- MC5-R -RRB- in the bovine adrenal cortex .
7956366	0	MC5R	56,60	melanocortin-5_receptor	26,49	MC5R	melanocortin-5 receptor	4161	4161	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human melanocortin-5_receptor gene -LRB- MC5R -RRB- to chromosome band 18p11 .2 by fluorescence in situ hybridization .
7905878	1	MCAD	139,143	hsp60	166,171	MCAD	hsp60	34	3329	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Demonstration of impaired transfer of K304E-variant MCAD from its complex with hsp60 to the native tetramer .
1684086	0	MCAD	156,160	medium-chain_Acyl-CoA_dehydrogenase	119,154	MCAD	medium-chain Acyl-CoA dehydrogenase	34	34	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular survey of a prevalent mutation , 985A-to-G transition , and identification of five infrequent mutations in the medium-chain_Acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in 55 patients with MCAD_deficiency .
10463467	0	MCAD	78,82	medium-chain_acyl-CoA_dehydrogenase	41,76	MCAD	medium-chain acyl-CoA dehydrogenase	34	34	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prevalence of the 985A > G mutation in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in Sweden .
19551636	0	MCAD	69,73	medium-chain_acyl-CoA_dehydrogenase	32,67	MCAD	medium-chain acyl-CoA dehydrogenase	34	34	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A985G mutation incidence in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in Brazil .
8099254	0	MCAD	115,119	medium-chain_acyl-CoA_dehydrogenase	78,113	MCAD	medium-chain acyl-CoA dehydrogenase	34	34	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Three RFLPs defining a haplotype associated with the common mutation in human medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- deficiency occur in Alu repeats .
8102510	0	MCAD	79,83	medium-chain_acyl-CoA_dehydrogenase	42,77	MCAD	medium-chain acyl-CoA dehydrogenase	34	34	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A rare disease-associated mutation in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene changes a conserved arginine , previously shown to be functionally essential in short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- .
8127075	0	MCAD	91,95	medium-chain_acyl-CoA_dehydrogenase	54,89	MCAD	medium-chain acyl-CoA dehydrogenase	34	34	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Scottish frequency of the common G985 mutation in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene and the role of MCAD_deficiency in sudden_infant_death_syndrome -LRB- SIDS -RRB- .
8590228	0	MCAD	73,77	medium-chain_acyl-CoA_dehydrogenase	36,71	MCAD	medium-chain acyl-CoA dehydrogenase	34	34	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Screening of A985_to_G mutation of medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in Normandy .
8682492	0	MCAD	79,83	medium-chain_acyl-CoA_dehydrogenase	42,77	MCAD	medium-chain acyl-CoA dehydrogenase	34	34	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Prevalence of carriers of the most common medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- deficiency mutation -LRB- G985A -RRB- in The Netherlands .
11400780	0	MCAD	66,70	medium-chain_acyl_CoA_dehydrogenase	29,64	MCAD	medium-chain acyl CoA dehydrogenase	34	34	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Screening of the most common medium-chain_acyl_CoA_dehydrogenase -LRB- MCAD -RRB- deficiency mutation -LRB- K329E -RRB- in the Czech newborn population .
1363805	0	MCAD	54,58	medium_chain_acyl-CoA_dehydrogenase	17,52	MCAD	medium chain acyl-CoA dehydrogenase	34	34	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the medium_chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene .
1937574	0	MCAF	85,89	IL-8	32,36	MCAF	IL-8	6347	3576	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	IL-1 and TNF-alpha induction of IL-8 and monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- mRNA expression in a human astrocytoma cell line .
2161898	0	MCAF	58,62	monocyte_chemotactic_and_activating_factor	14,56	MCAF	monocyte chemotactic and activating factor	6347	6347	Gene	Gene	Properties|appos|START_ENTITY Properties|nmod|END_ENTITY	Properties of monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- purified from a human fibrosarcoma cell line .
2471522	0	MCAF	58,62	monocyte_chemotactic_and_activating_factor	14,56	MCAF	monocyte chemotactic and activating factor	6347	6347	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- by human dermal fibroblasts in response to interleukin 1 or tumor_necrosis_factor .
24598729	0	MCAF1	0,5	BZLF1	24,29	MCAF1	BZLF1	55729	3783744(Tax:10376)	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	MCAF1 and Rta-activated BZLF1 transcription in Epstein-Barr_virus .
20385599	0	MCAF1	0,5	Rta	91,94	MCAF1	Rta	55729	116535	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	MCAF1 and synergistic activation of the transcription of Epstein-Barr_virus lytic genes by Rta and Zta .
14960279	0	MCAK	19,23	Aurora_B	0,8	MCAK	Aurora B	11004	9212	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Aurora_B regulates MCAK at the mitotic centromere .
14972678	0	MCAK	36,40	Aurora_B	0,8	MCAK	Aurora B	380006(Tax:8355)	398457(Tax:8355)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Aurora_B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity .
15120087	0	MCAK	9,13	Aurora_B	32,40	MCAK	Aurora B	11004	9212	Gene	Gene	START_ENTITY|nmod|aura aura|nmod|END_ENTITY	Mitosis : MCAK under the aura of Aurora_B .
16950107	0	MCAK	71,75	Aurora_B	0,8	MCAK	Aurora B	11004	9212	Gene	Gene	regulates|dobj|START_ENTITY sites|acl:relcl|regulates enriched|nmod|sites enriched|nsubjpass|END_ENTITY	Aurora_B is enriched at merotelic attachment sites , where it regulates MCAK .
24291095	0	MCAK	18,22	Aurora_B	0,8	MCAK	Aurora B	11004	9212	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Aurora_B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association .
17968321	0	MCAK	0,4	EB1	21,24	MCAK	EB1	11004	22919	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	MCAK associates with EB1 .
25002679	0	MCAK	27,31	Rac1	0,4	MCAK	Rac1	11004	5879	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Rac1 and Aurora_A regulate MCAK to polarize microtubule growth in migrating endothelial cells .
25595133	0	MCAM	59,63	CD146	65,70	MCAM	CD146	4162	4162	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Endothelial-binding , proinflammatory T cells identified by MCAM -LRB- CD146 -RRB- expression : Characterization and role in human autoimmune_diseases .
15610525	0	MCAM	25,29	Endothelin-1	0,12	MCAM	Endothelin-1	4162	1906	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Endothelin-1 upregulates MCAM in melanocytes .
11934156	0	MCAM	33,37	Melanoma_Cell_Adhesion_Molecule	0,31	MCAM	Melanoma Cell Adhesion Molecule	448832(Tax:9031)	448832(Tax:9031)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Melanoma_Cell_Adhesion_Molecule -LRB- MCAM -RRB- expression in the myogenic lineage during early chick embryonic development .
17569608	0	MCAM	63,67	melanoma_cell_adhesion_molecule	30,61	MCAM	melanoma cell adhesion molecule	4162	4162	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Stratification of patients by melanoma_cell_adhesion_molecule -LRB- MCAM -RRB- expression on the basis of risk : implications for sentinel_lymph_node_biopsy .
24824780	0	MCC	0,3	DBC1	67,71	MCC	DBC1	328949(Tax:10090)	56710(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm .
19555689	0	MCC	0,3	Scrib	35,40	MCC	Scrib	4163	23513	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	MCC , a new interacting protein for Scrib , is required for cell migration in epithelial cells .
24824780	0	MCC	0,3	beta-catenin	13,25	MCC	beta-catenin	328949(Tax:10090)	12387(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm .
10449536	0	MCC	16,19	mutated_in_colorectal_cancer	21,49	MCC	mutated in colorectal cancer	328949(Tax:10090)	328949(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of MCC -LRB- mutated_in_colorectal_cancer -RRB- in various tissues of mice and its involvement in cell differentiation .
11311560	0	MCC2	15,19	AIE-75	88,94	MCC2	AIE-75	83878	10083	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of MCC2 , a novel homologue of MCC_tumor suppressor , with PDZ-domain Protein AIE-75 .
16752391	0	MCEE	72,76	methylmalonyl-CoA_epimerase	38,65	MCEE	methylmalonyl-CoA epimerase	84693	84693	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A homozygous nonsense mutation in the methylmalonyl-CoA_epimerase gene -LRB- MCEE -RRB- results in mild methylmalonic_aciduria .
17010120	0	MCFD2	34,39	ERGIC-53	25,33	MCFD2	ERGIC-53	90411	3998	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Cargo selectivity of the ERGIC-53 / MCFD2 transport receptor complex .
16044454	0	MCFD2	17,22	LMAN1	56,61	MCFD2	FVIII	90411	2157	Gene	Gene	gene|compound|START_ENTITY Mutations|nmod|gene Mutations|nmod|gene gene|compound|END_ENTITY	Mutations in the MCFD2 gene and a novel mutation in the LMAN1 gene in Indian families with combined deficiency_of_factor_V and VIII .
10891498	0	MCG10	0,5	p53	15,18	MCG10	p53	57060	7157	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	MCG10 , a novel p53 target gene that encodes a KH domain RNA-binding protein , is capable of inducing apoptosis and cell cycle arrest in G -LRB- 2 -RRB- - M. p53 , a tumor suppressor , inhibits cell proliferation by inducing cellular genes involved in the regulation of the cell cycle .
11274220	0	MCH	73,76	MCH2	53,57	MCH	MCH2	5367	84539	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Molecular cloning and functional characterization of MCH2 , a novel human MCH receptor .
11278733	0	MCH	123,126	SLC-1	106,111	MCH	SLC-1	5367	2847	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Structure-activity relationship studies of melanin-concentrating_hormone -LRB- MCH -RRB- - related peptide ligands at SLC-1 , the human MCH receptor .
10071774	0	MCH	100,103	melanin-concentrating_hormone	69,98	MCH	melanin-concentrating hormone	5367	5367	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Synthesis and characterization of new radioligands for the mammalian melanin-concentrating_hormone -LRB- MCH -RRB- receptor .
20144885	0	MCH	96,99	melanin_concentrating_hormone	65,94	MCH	melanin concentrating hormone	5367	5367	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Distribution of hypothalamic neurons with orexin -LRB- hypocretin -RRB- or melanin_concentrating_hormone -LRB- MCH -RRB- immunoreactivity and multisynaptic connections with diaphragm motoneurons .
17329101	0	MCH-R1	98,104	melanin-concentrating_hormone_receptor-1	56,96	MCH-R1	melanin-concentrating hormone receptor-1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Thienopyrimidinone_bis-aminopyrrolidine ureas as potent melanin-concentrating_hormone_receptor-1 -LRB- MCH-R1 -RRB- antagonists .
18682323	0	MCH-R1	106,112	melanin-concentrating_hormone_receptor_1	64,104	MCH-R1	melanin-concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
19500982	0	MCH-R1	89,95	melanin-concentrating_hormone_receptor_1	47,87	MCH-R1	melanin-concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Optimization of piperidin-4-yl-urea-containing melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists : Reducing hERG-associated liabilities .
21420863	0	MCH-R1	119,125	melanin-concentrating_hormone_receptor_1	77,117	MCH-R1	melanin-concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
22249825	0	MCH-R1	65,71	melanin-concentrating_hormone_receptor_1	23,63	MCH-R1	melanin-concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Antiobesity effects of melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
23411080	0	MCH-R1	116,122	melanin_concentrating_hormone_receptor_1	74,114	MCH-R1	melanin concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Synthesis and SAR study of pyrrolo -LSB- 3,4-b -RSB- pyridin-7 -LRB- 6H -RRB- - one derivatives as melanin_concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
17897030	0	MCH1-R	57,63	melanin-concentrating_hormone_1-receptor	15,55	MCH1-R	melanin-concentrating hormone 1-receptor	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Aminoquinoline melanin-concentrating_hormone_1-receptor -LRB- MCH1-R -RRB- antagonists .
19457661	0	MCH1R	92,97	melanin-concentrating_hormone_1-receptor	50,90	MCH1R	melanin-concentrating hormone 1-receptor	83567(Tax:10116)	83567(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Identification of 2-aminobenzimidazoles as potent melanin-concentrating_hormone_1-receptor -LRB- MCH1R -RRB- antagonists .
11274220	0	MCH2	53,57	MCH	73,76	MCH2	MCH	84539	5367	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Molecular cloning and functional characterization of MCH2 , a novel human MCH receptor .
18940788	0	MCH5	103,107	Put3	43,47	MCH5	Put3	854483(Tax:4932)	853854(Tax:4932)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces_cerevisiae .
20724156	0	MCHR1	97,102	melanin_concentrating_hormone_receptor_1	55,95	MCHR1	melanin concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of novel , orally available benzimidazoles as melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonists .
22487182	0	MCHR1	96,101	melanin_concentrating_hormone_receptor_1	54,94	MCHR1	melanin concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Design and optimization of quinazoline derivatives as melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonists .
22497763	0	MCHR1	96,101	melanin_concentrating_hormone_receptor_1	54,94	MCHR1	melanin concentrating hormone receptor 1	2847	2847	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Design and optimization of quinazoline derivatives as melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonists : part 2 .
22542010	0	MCHR1	63,68	melanin_concentrating_hormone_receptor_1	21,61	MCHR1	melanin concentrating hormone receptor 1	207911(Tax:10090)	207911(Tax:10090)	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of a novel melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonist with reduced hERG inhibition .
12220661	0	MCHR1	53,58	ppMCH	27,32	MCHR1	ppMCH	2847	5367	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|dobj|receptor	Human immune cells express ppMCH mRNA and functional MCHR1 receptor .
16049974	0	MCJ	27,30	DNAJD1	32,38	MCJ	DNAJD1	29103	29103	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Epigenetic inactivation of MCJ -LRB- DNAJD1 -RRB- in malignant paediatric_brain_tumours .
9464547	0	MCK	46,49	p53	62,65	MCK	p53	1158	7157	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Synergistic transcriptional activation of the MCK promoter by p53 : tetramers link separated DNA response elements by DNA looping .
18089567	0	MCL-1	0,5	BAX	15,18	MCL-1	BAX	4170	581	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	MCL-1	0,5	BAX	43,46	MCL-1	BAX	4170	581	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|BAX BAX|nmod|absence absence|nmod|Interaction Interaction|compound|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	MCL-1	37,42	BAX	15,18	MCL-1	BAX	4170	581	Gene	Gene	Interaction|compound|START_ENTITY absence|nmod|Interaction END_ENTITY|nmod|absence	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	MCL-1	37,42	BAX	43,46	MCL-1	BAX	4170	581	Gene	Gene	Interaction|compound|START_ENTITY Interaction|compound|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
23681223	0	MCL-1	32,37	BECN1	0,5	MCL-1	BECN1	4170	8678	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells .
18789152	0	MCL-1	138,143	BIRC5	130,135	MCL-1	BIRC5	4170	332	Gene	Gene	survivin|amod|START_ENTITY survivin|appos|END_ENTITY	Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans_retinoic_acid -LRB- ATRA -RRB- through downregulation of survivin -LRB- BIRC5 -RRB- , MCL-1 and LTbeta-R in hormone - and drug resistant_prostate_cancer cell line , DU-145 .
18089567	0	MCL-1	0,5	MCL-1	37,42	MCL-1	MCL-1	4170	4170	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|BAX BAX|nmod|absence absence|nmod|Interaction Interaction|compound|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
18089567	0	MCL-1	37,42	MCL-1	0,5	MCL-1	MCL-1	4170	4170	Gene	Gene	Interaction|compound|START_ENTITY absence|nmod|Interaction BAX|nmod|absence inhibits|dobj|BAX inhibits|nsubj|END_ENTITY	MCL-1 inhibits BAX in the absence of MCL-1 / BAX Interaction .
21471522	0	MCL-1	114,119	MiR-29a	0,7	MCL-1	MiR-29a	17210(Tax:10090)	387222(Tax:10090)	Gene	Gene	overexpression|compound|START_ENTITY apoptosis|nmod|overexpression contributes|xcomp|apoptosis contributes|nsubj|down-regulation down-regulation|amod|END_ENTITY	MiR-29a down-regulation in ALK-positive anaplastic_large_cell_lymphomas contributes to apoptosis blockade through MCL-1 overexpression .
22361683	0	MCL-1	126,131	NOXA	0,4	MCL-1	NOXA	4170	5366	Gene	Gene	blocked|nmod|START_ENTITY pathway|acl:relcl|blocked degraded|nmod|pathway degraded|nsubjpass|END_ENTITY	NOXA , a sensor of proteasome integrity , is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1 .
24525728	0	MCL-1	46,51	Noxa	0,4	MCL-1	Noxa	4170	5366	Gene	Gene	sensitivity|compound|START_ENTITY localization|nmod|sensitivity determines|dobj|localization determines|nsubj|END_ENTITY	Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small_cell_lung_cancer .
25724519	0	MCL-1	78,83	miR-137	0,7	MCL-1	miR-137	4170	406928	Gene	Gene	Apoptosis|nmod|START_ENTITY Apoptosis|compound|END_ENTITY	miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple_Myeloma .
24260268	0	MCL-1ES	0,7	BAX	33,36	MCL-1ES	BAX	4170	581	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	MCL-1ES induces MCL-1L-dependent BAX - and BAK-independent mitochondrial apoptosis .
19683529	0	MCL-1ES	0,7	MCL-1L	51,57	MCL-1ES	MCL-1L	4170	4170	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	MCL-1ES , a novel variant of MCL-1 , associates with MCL-1L and induces mitochondrial cell death .
19683529	0	MCL-1L	51,57	MCL-1ES	0,7	MCL-1L	MCL-1ES	4170	4170	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	MCL-1ES , a novel variant of MCL-1 , associates with MCL-1L and induces mitochondrial cell death .
21368833	0	MCL1	52,56	SCF	0,3	MCL1	SCF	4170	4254	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	SCF -LRB- FBW7 -RRB- regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction .
22653344	0	MCM-2	76,81	MCM-5	83,88	MCM-2	MCM-5	4171	4174	Gene	Gene	index|compound|START_ENTITY index|dep|END_ENTITY	Replication protein A in nonearly ovarian_adenocarcinomas : correlation with MCM-2 , MCM-5 , Ki-67 index and prognostic significance .
22653344	0	MCM-5	83,88	MCM-2	76,81	MCM-5	MCM-2	4174	4171	Gene	Gene	index|dep|START_ENTITY index|compound|END_ENTITY	Replication protein A in nonearly ovarian_adenocarcinomas : correlation with MCM-2 , MCM-5 , Ki-67 index and prognostic significance .
9745018	0	MCM10	150,155	DNA43	143,148	MCM10	DNA43	854656(Tax:4932)	854656(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	The essential schizosaccharomyces_pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces_cerevisiae DNA43 -LRB- MCM10 -RRB- gene .
11278932	0	MCM2	20,24	HBO1	78,82	MCM2	HBO1	4171	11143	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1 .
26712671	0	MCM2	30,34	Minichromosome_maintenance-2	0,28	MCM2	Minichromosome maintenance-2	4171	4171	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Minichromosome_maintenance-2 -LRB- MCM2 -RRB- expression differentiates oral_squamous_cell_carcinoma from pre-cancerous lesions .
18373176	0	MCM2	30,34	Minichromosome_maintenance_2	0,28	MCM2	Minichromosome maintenance 2	4171	4171	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Minichromosome_maintenance_2 -LRB- MCM2 -RRB- immunoreactivity in stage III human gastric_carcinoma : clinicopathological significance .
20122406	0	MCM2-7	18,24	helicase	25,33	MCM2-7	helicase	40973(Tax:7227)	33118(Tax:7227)	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins .
25809478	0	MCM3	50,54	Chk1	59,63	MCM3	Chk1	4172	1111	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of mini-chromosome_maintenance 3 -LRB- MCM3 -RRB- by Chk1 negatively regulates DNA replication and checkpoint activation .
11258703	0	MCM3	70,74	MCM3AP	0,6	MCM3	MCM3AP	4172	8888	Gene	Gene	acetylates|dobj|START_ENTITY acetyltransferase|acl:relcl|acetylates END_ENTITY|appos|acetyltransferase	MCM3AP , a novel acetyltransferase that acetylates replication protein MCM3 .
12226073	0	MCM3	107,111	MCM3AP	19,25	MCM3	MCM3AP	4172	8888	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The MCM3 acetylase MCM3AP inhibits initiation , but not elongation , of DNA replication via interaction with MCM3 .
11258703	0	MCM3AP	0,6	MCM3	70,74	MCM3AP	MCM3	8888	4172	Gene	Gene	START_ENTITY|appos|acetyltransferase acetyltransferase|acl:relcl|acetylates acetylates|dobj|END_ENTITY	MCM3AP , a novel acetyltransferase that acetylates replication protein MCM3 .
12226073	0	MCM3AP	19,25	MCM3	107,111	MCM3AP	MCM3	8888	4172	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The MCM3 acetylase MCM3AP inhibits initiation , but not elongation , of DNA replication via interaction with MCM3 .
17046832	0	MCM4	19,23	Cdc7	27,31	MCM4	Cdc7	4173	8317	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin .
17310990	0	MCM7	26,30	INT6	6,10	MCM7	INT6	4176	3646	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle .
18657502	0	MCM9	0,4	Cdt1	11,15	MCM9	Cdt1	254394	81620	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	MCM9 binds Cdt1 and is required for the assembly of prereplication complexes .
19763610	0	MCOLN-2	42,49	TRPML2	34,40	MCOLN-2	TRPML2	68279(Tax:10090)	68279(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The tissue-specific expression of TRPML2 -LRB- MCOLN-2 -RRB- gene is influenced by the presence of TRPML1 .
1386357	0	MCP	144,147	C4b	52,55	MCP	C4b	4179	721	Gene	Gene	receptor|appos|START_ENTITY pathway|nmod|receptor inactivation|nmod|pathway inactivation|nmod|END_ENTITY	Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- and membrane_cofactor_protein -LRB- MCP , CD46 -RRB- .
1386357	0	MCP	144,147	CR1	102,105	MCP	CR1	4179	1378	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Factor I-dependent inactivation of human complement C4b of the classical pathway by C3b/C4b _ receptor -LRB- CR1 , CD35 -RRB- and membrane_cofactor_protein -LRB- MCP , CD46 -RRB- .
1940444	0	MCP	63,66	membrane_co-factor_protein	35,61	MCP	membrane co-factor protein	4179	4179	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and characterization of membrane_co-factor_protein -LRB- MCP -RRB- in human skin .
10468303	0	MCP	41,44	membrane_cofactor_protein	14,39	MCP	membrane cofactor protein	4179	4179	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of membrane_cofactor_protein -LRB- MCP , CD46 -RRB- in human liver_diseases .
12112588	0	MCP	53,56	membrane_cofactor_protein	26,51	MCP	membrane cofactor protein	4179	4179	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human membrane_cofactor_protein -LRB- MCP ; CD46 -RRB- on spermatozoa .
1694203	0	MCP	52,55	membrane_cofactor_protein	25,50	MCP	membrane cofactor protein	4179	4179	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Quantitative analysis of membrane_cofactor_protein -LRB- MCP -RRB- of complement .
2521358	0	MCP	53,56	membrane_cofactor_protein	26,51	MCP	membrane cofactor protein	4179	4179	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Structural gene for human membrane_cofactor_protein -LRB- MCP -RRB- of complement maps to within 100 kb of the 3 ' end of the C3b/C4b _ receptor gene .
7861396	0	MCP	73,76	membrane_cofactor_protein	46,71	MCP	membrane cofactor protein	4179	4179	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of the complement-regulatory protein membrane_cofactor_protein -LRB- MCP , CD46 -RRB- as a membrane-associated product in seminal plasma .
18296557	0	MCP-1	48,53	12/15-lipoxygenase	8,26	MCP-1	12/15-lipoxygenase	20296(Tax:10090)	11687(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Role of 12/15-lipoxygenase in the expression of MCP-1 in mouse macrophages .
25914608	0	MCP-1	29,34	ATF4	0,4	MCP-1	ATF4	20296(Tax:10090)	11911(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells .
25914608	0	MCP-1	29,34	ATF4	0,4	MCP-1	ATF4	20296(Tax:10090)	11911(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells .
14733413	0	MCP-1	51,56	Adrenomedullin	0,14	MCP-1	Adrenomedullin	24770(Tax:10116)	25026(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Adrenomedullin inhibits pressure-induced mesangial MCP-1 expression through activation of protein_kinase_A .
26488172	0	MCP-1	40,45	Akt	88,91	MCP-1	Akt	6347	207	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Activation Activation|nmod|END_ENTITY	sPLA2-IIA Augments Oxidized LDL-Induced MCP-1 Expression in Vitro Through Activation of Akt .
19448902	0	MCP-1	26,31	Angiotensin_II	0,14	MCP-1	Angiotensin II	24770(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates MCP-1 production in rat glomerular endothelial cells via NAD -LRB- P -RRB- H oxidase-dependent nuclear factor-kappa B signaling .
12851645	0	MCP-1	33,38	CCL2	27,31	MCP-1	CCL2	6347	6347	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Significant involvement of CCL2 -LRB- MCP-1 -RRB- in inflammatory disorders of the lung .
17709550	0	MCP-1	24,29	CCL2	30,34	MCP-1	CCL2	6347	6347	Gene	Gene	START_ENTITY|parataxis|sufficient sufficient|nsubj|END_ENTITY	Tumor-derived chemokine MCP-1 / CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells .
20652055	0	MCP-1	38,43	CCL2	44,48	MCP-1	CCL2	20296(Tax:10090)	20296(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Rhizoma Coptidis inhibits LPS-induced MCP-1 / CCL2 production in murine macrophages via an AP-1 and NFkappaB-dependent pathway .
21029462	0	MCP-1	34,39	CCL2	40,44	MCP-1	CCL2	6347	6347	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|END_ENTITY	Spiral ligament fibrocyte-derived MCP-1 / CCL2 contributes to inner_ear_inflammation secondary to nontypeable H. _ influenzae-induced otitis media .
21385934	0	MCP-1	124,129	CCL2	130,134	MCP-1	CCL2	6347	6347	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral_squamous_cell_carcinoma metastasis by downregulating MCP-1 / CCL2 expression .
22240432	0	MCP-1	4,9	CCL2	11,15	MCP-1	CCL2	6347	6347	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	The MCP-1 -LRB- CCL2 -RRB- -2518 GG genotype is associated with protection against pulmonary_tuberculosis in Moroccan patients .
25199511	0	MCP-1	136,141	CCL2	142,146	MCP-1	CCL2	6347	6347	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Focal_Adhesion_Kinase Knockdown in Carcinoma-Associated Fibroblasts Inhibits Oral Squamous Cell Carcinoma Metastasis via Downregulating MCP-1 / CCL2 Expression .
10419877	0	MCP-1	152,157	CCR2	8,12	MCP-1	CCR2	6347	729230	Gene	Gene	role|nmod|START_ENTITY Loss|dep|role Loss|nmod|expression expression|compound|END_ENTITY	Loss of CCR2 expression and functional response to monocyte_chemotactic_protein -LRB- MCP-1 -RRB- during the differentiation of human monocytes : role of secreted MCP-1 in the regulation of the chemotactic response .
10419877	0	MCP-1	81,86	CCR2	8,12	MCP-1	CCR2	6347	729230	Gene	Gene	monocyte_chemotactic_protein|appos|START_ENTITY expression|nmod|monocyte_chemotactic_protein expression|compound|END_ENTITY	Loss of CCR2 expression and functional response to monocyte_chemotactic_protein -LRB- MCP-1 -RRB- during the differentiation of human monocytes : role of secreted MCP-1 in the regulation of the chemotactic response .
10479649	0	MCP-1	59,64	CCR2	14,18	MCP-1	CCR2	6347	729230	Gene	Gene	implications|nmod|START_ENTITY Expression|dep|implications Expression|nmod|END_ENTITY	Expression of CCR2 by endothelial cells : implications for MCP-1 mediated wound_injury repair and In vivo inflammatory activation of endothelium .
10710532	0	MCP-1	0,5	CCR2	25,29	MCP-1	CCR2	6347	729230	Gene	Gene	START_ENTITY|dep|haptotaxis haptotaxis|nummod|END_ENTITY	MCP-1 in pleural_injury : CCR2 mediates haptotaxis of pleural mesothelial cells .
11518728	0	MCP-1	32,37	CCR2	38,42	MCP-1	CCR2	17224(Tax:10090)	12772(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Critical role for the chemokine MCP-1 / CCR2 in the pathogenesis of bronchiolitis_obliterans_syndrome .
12078856	0	MCP-1	13,18	CCR2	66,70	MCP-1	CCR2	6347	729230	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression Induction|dep|role role|nmod|receptor receptor|nummod|END_ENTITY	Induction of MCP-1 expression in airway epithelial cells : role of CCR2 receptor in airway epithelial injury .
15629146	0	MCP-1	116,121	CCR2	29,33	MCP-1	CCR2	6347	729230	Gene	Gene	binding|compound|START_ENTITY important|nmod|binding transmembrane|xcomp|important identified|advcl|transmembrane identified|nsubj|mutagenesis mutagenesis|nmod|END_ENTITY	Site-directed mutagenesis of CCR2 identified amino_acid residues in transmembrane helices 1 , 2 , and 7 important for MCP-1 binding and biological functions .
16095529	0	MCP-1	11,16	CCR2	17,21	MCP-1	CCR2	6347	729230	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for MCP-1 / CCR2 in interstitial_lung_disease in children .
16150057	0	MCP-1	69,74	CCR2	27,31	MCP-1	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	CCL2|compound|START_ENTITY chemokine|nmod|CCL2 chemokine|nsubj|expression expression|nmod|END_ENTITY	Constitutive expression of CCR2 chemokine receptor and inhibition by MCP-1 / CCL2 of GABA-induced currents in spinal cord neurones .
16196033	0	MCP-1	148,153	CCR2	36,40	MCP-1	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY expression|dep|effect expression|nmod|receptor receptor|compound|END_ENTITY	Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain : functional effect of MCP-1 / CCL2 on calcium mobilization in primary cultured neurons .
16518346	0	MCP-1	4,9	CCR2	10,14	MCP-1	CCR2	6347	729230	Gene	Gene	START_ENTITY|parataxis|has has|nsubj|system system|compound|END_ENTITY	The MCP-1 / CCR2 system has direct proinflammatory effects in human mesangial cells .
16857270	0	MCP-1	0,5	CCR2	25,29	MCP-1	CCR2	6347	729230	Gene	Gene	chemokine|amod|START_ENTITY END_ENTITY|amod|chemokine	MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic_lateral_sclerosis -LRB- sALS -RRB- .
17222215	0	MCP-1	0,5	CCR2	6,10	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|pathway pathway|compound|END_ENTITY	MCP-1 / CCR2 signalling pathway regulates hyperoxia-induced acute_lung_injury via nitric_oxide production .
17631861	0	MCP-1	14,19	CCR2	20,24	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|ameliorates ameliorates|nsubj|END_ENTITY	Inhibition of MCP-1 / CCR2 pathway ameliorates the development of diabetic_nephropathy .
18463419	0	MCP-1	14,19	CCR2	20,24	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|inhibit inhibit|nsubj|signaling signaling|compound|END_ENTITY	Inhibition of MCP-1 / CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model .
18579703	0	MCP-1	0,5	CCR2	6,10	MCP-1	CCR2	6347	729230	Gene	Gene	START_ENTITY|appos|involved involved|nsubjpass|system system|compound|END_ENTITY	MCP-1 / CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells .
19002595	0	MCP-1	14,19	CCR2	20,24	MCP-1	CCR2	6347	729230	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|promotes promotes|nsubj|axis axis|compound|END_ENTITY	Activation of MCP-1 / CCR2 axis promotes prostate_cancer growth in bone .
19942750	0	MCP-1	6,11	CCR2	0,4	MCP-1	CCR2	6347	729230	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|compound|END_ENTITY	CCR2 , MCP-1 , SDF-1a _ DC-SIGN gene polymorphisms in HIV-1 infected patients with _ without tuberculosis .
20180766	0	MCP-1	14,19	CCR2	20,24	MCP-1	CCR2	6347	729230	Gene	Gene	Targeting|dobj|START_ENTITY System|dep|Targeting System|compound|END_ENTITY	Targeting the MCP-1 / CCR2 System in diabetic_kidney_disease .
21589925	0	MCP-1	0,5	CCR2	137,141	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	MCP-1 upregulates amylin expression in murine pancreatic b cells through ERK/JNK-AP 1 and NF-kB related signaling pathways independent of CCR2 .
22006533	0	MCP-1	4,9	CCR2	10,14	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|axis axis|nummod|END_ENTITY	The MCP-1 / CCR2 axis in podocytes is involved in apoptosis induced by diabetic_conditions .
22740067	0	MCP-1	0,5	CCR2	6,10	MCP-1	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	START_ENTITY|appos|interactions interactions|nsubj|END_ENTITY	MCP-1 / CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes .
23007133	0	MCP-1	40,45	CCR2	47,51	MCP-1	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	monocyte_chemoattractant_protein-1|dep|START_ENTITY system|amod|monocyte_chemoattractant_protein-1 system|compound|END_ENTITY	The monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- / CCR2 system is involved in peritoneal_dialysis-related epithelial-mesenchymal transition of peritoneal mesothelial cells .
23107893	0	MCP-1	14,19	CCR2	20,24	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|involved involved|nsubjpass|signaling signaling|compound|END_ENTITY	Inhibition of MCP-1 / CCR2 signaling pathway is involved in synergistic inhibitory effects of irbesartan with rosuvastatin on vascular remodeling .
23408426	0	MCP-1	159,164	CCR2	41,45	MCP-1	CCR2	6347	729230	Gene	Gene	monocyte_chemoattractant_protein-1|appos|START_ENTITY forms|nmod|monocyte_chemoattractant_protein-1 enhances|nmod|forms enhances|nsubj|sulfation sulfation|nmod|END_ENTITY	Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- .
24252211	0	MCP-1	0,5	CCR2	6,10	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	START_ENTITY|appos|accelerated accelerated|nsubjpass|astrocytosis astrocytosis|nummod|END_ENTITY	MCP-1 / CCR2 signaling-mediated astrocytosis is accelerated in a transgenic mouse model of SOD1-mutated familial ALS .
24416305	0	MCP-1	42,47	CCR2	48,52	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Monocytes infiltrate the pancreas via the MCP-1 / CCR2 pathway and differentiate into stellate cells .
25970072	0	MCP-1	25,30	CCR2	31,35	MCP-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	Spiegelmer-Inhibition|nmod|START_ENTITY Spiegelmer-Inhibition|dep|END_ENTITY	Spiegelmer-Inhibition of MCP-1 / CCR2 - potential as an adjunct immunosuppressive therapy in transplantation .
26733169	0	MCP-1	94,99	CCR2	100,104	MCP-1	CCR2	6347	729230	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Human umbilical cord mesenchymal stem cells delivering sTRAIL home to lung_cancer mediated by MCP-1 / CCR2 axis and exhibit antitumor effects .
25132583	0	MCP-1	177,182	CCR5	171,175	MCP-1	CCR5	6347	1234	Gene	Gene	IL-10|dep|START_ENTITY IL-10|compound|END_ENTITY	Incidence and dynamics of active cytomegalovirus_infection in allogeneic stem cell transplant patients according to single nucleotide polymorphisms in donor and recipient CCR5 , MCP-1 , IL-10 , and TLR9 genes .
20100200	0	MCP-1	9,14	CD14	33,37	MCP-1	CD14	6347	929	Gene	Gene	release|compound|START_ENTITY release|nmod|cells cells|compound|END_ENTITY	Enhanced MCP-1 release by keloid CD14 + cells augments fibroblast proliferation : role of MCP-1 and Akt pathway in keloids .
12126640	0	MCP-1	28,33	Ccr2	0,4	MCP-1	Ccr2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	CCL2|compound|START_ENTITY level|nmod|CCL2 regulates|dobj|level regulates|nsubj|END_ENTITY	Ccr2 regulates the level of MCP-1 / CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen .
19942750	0	MCP-1	6,11	DC-SIGN	22,29	MCP-1	DC-SIGN	6347	30835	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|compound|END_ENTITY	CCR2 , MCP-1 , SDF-1a _ DC-SIGN gene polymorphisms in HIV-1 infected patients with _ without tuberculosis .
19822078	0	MCP-1	121,126	Duffy_antigen	17,30	MCP-1	Duffy antigen	6347	2532	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of the Duffy_antigen on pharmacokinetics and pharmacodynamics of recombinant monocyte chemoattractant protein -LRB- MCP-1 , CCL-2 -RRB- in vivo .
24993819	0	MCP-1	15,20	IL-1b	0,5	MCP-1	IL-1b	6347	3553	Gene	Gene	induction|compound|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	IL-1b mediates MCP-1 induction by Wnt5a in gastric_cancer cells .
11866893	0	MCP-1	76,81	IL-1beta	12,20	MCP-1	IL-1beta	6347	3553	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	-LSB- Effects of IL-1beta , TNF-alpha and lipopolysaccharide on the expression of MCP-1 in human umbilical vein endothelial cells -RSB- .
10644881	0	MCP-1	23,28	IL-6	61,65	MCP-1	IL-6	6347	3569	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Selective induction of MCP-1 in human mesangial cells by the IL-6 / sIL-6R complex .
18400310	0	MCP-1	15,20	IL-6	0,4	MCP-1	IL-6	6347	3569	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-6 regulates MCP-1 , ICAM-1 and IL-6 expression in human myoblasts .
18976114	0	MCP-1	155,160	IL-6	149,153	MCP-1	IL-6	100360872	24498(Tax:10116)	Gene	Gene	glucose|appos|START_ENTITY glucose|appos|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
22683409	0	MCP-1	65,70	IL-6	12,16	MCP-1	IL-6	6347	3569	Gene	Gene	production|nmod|START_ENTITY inhibited|dobj|production inhibited|nsubj|Blockade Blockade|nmod|END_ENTITY	Blockade of IL-6 and TNF-a inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction .
22832157	0	MCP-1	27,32	IL-6	15,19	MCP-1	IL-6	6347	3569	Gene	Gene	CRP|appos|START_ENTITY CRP|compound|END_ENTITY	Elevated serum IL-6 , IL-8 , MCP-1 , CRP , and IFN-y levels in 10 - to 11-year-old boys with increased BMI .
11835523	0	MCP-1	54,59	IL-8	80,84	MCP-1	IL-8	6347	3576	Gene	Gene	monocyte_chemoattractant_protein-1|appos|START_ENTITY monocyte_chemoattractant_protein-1|appos|END_ENTITY	Urinary levels of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and interleukin-8 -LRB- IL-8 -RRB- , and renal_injuries in patients with type 2 diabetic_nephropathy .
22832157	0	MCP-1	27,32	IL-8	21,25	MCP-1	IL-8	6347	3576	Gene	Gene	CRP|appos|START_ENTITY CRP|appos|END_ENTITY	Elevated serum IL-6 , IL-8 , MCP-1 , CRP , and IFN-y levels in 10 - to 11-year-old boys with increased BMI .
25704572	0	MCP-1	12,17	IL-8	36,40	MCP-1	IL-8	6347	3576	Gene	Gene	START_ENTITY|nmod|appraisal appraisal|compound|END_ENTITY	Addition of MCP-1 and MIP-3b to the IL-8 appraisal in peritoneal fluid enhances the probability of identifying women with endometriosis .
25785032	0	MCP-1	59,64	IL-8	53,57	MCP-1	IL-8	6347	3576	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Ghrelin inhibits AngII - induced expression of TNF-a , IL-8 , MCP-1 in human umbilical vein endothelial cells .
9132652	0	MCP-1	8,13	IL-8	14,18	MCP-1	IL-8	6347	3576	Gene	Gene	ratio|dep|START_ENTITY ratio|compound|END_ENTITY	Inverse MCP-1 / IL-8 ratio in effluents of CAPD patients with peritonitis and in isolated cultured human peritoneal macrophages .
12923954	0	MCP-1	40,45	Il-8	27,31	MCP-1	Il-8	6347	3576	Gene	Gene	Il-10|dep|START_ENTITY Il-10|dep|END_ENTITY	-LSB- Selected cytokines -LRB- Il-6 , Il-8 , Il-10 , MCP-1 , TNF-alpha -RRB- in children and adolescents with atherosclerosis risk factors : obesity , hypertension , diabetes -RSB- .
18270300	0	MCP-1	22,27	Insulin	0,7	MCP-1	Insulin	6347	3630	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Insulin regulation of MCP-1 in human adipose tissue of obese and lean women .
16186362	0	MCP-1	14,19	JNK	0,3	MCP-1	JNK	6347	5599	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	JNK regulates MCP-1 expression in adenovirus type 19-infected human corneal fibroblasts .
24086554	0	MCP-1	84,89	JNK	149,152	MCP-1	JNK	6347	5599	Gene	Gene	production|compound|START_ENTITY production|nmod|inactivation inactivation|nmod|END_ENTITY	Febuxostat , an inhibitor of xanthine oxidase , suppresses lipopolysaccharide-induced MCP-1 production via MAPK_phosphatase-1-mediated inactivation of JNK .
24966899	0	MCP-1	49,54	JNK	118,121	MCP-1	JNK	6347	5599	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nmod|pathways pathways|compound|END_ENTITY	TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-kB signal pathways .
19751783	0	MCP-1	37,42	LDLR	52,56	MCP-1	LDLR	17224(Tax:10090)	16835(Tax:10090)	Gene	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Ghrelin vaccination decreases plasma MCP-1 level in LDLR -LRB- - / - -RRB- - mice .
10891427	0	MCP-1	52,57	MCP-1	74,79	MCP-1	MCP-1	6347	6347	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Human endothelial cells express CCR2 and respond to MCP-1 : direct role of MCP-1 in angiogenesis and tumor progression .
10891427	0	MCP-1	74,79	MCP-1	52,57	MCP-1	MCP-1	6347	6347	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Human endothelial cells express CCR2 and respond to MCP-1 : direct role of MCP-1 in angiogenesis and tumor progression .
20711880	0	MCP-1	127,132	MCP-1	93,98	MCP-1	MCP-1	6347	6347	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Effect of the C-terminal domain peptide fragment -LRB- 65-76 -RRB- of monocytic_chemotactic_protein-1 -LRB- MCP-1 -RRB- on the interaction between MCP-1 and heparin .
20711880	0	MCP-1	93,98	MCP-1	127,132	MCP-1	MCP-1	6347	6347	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Effect of the C-terminal domain peptide fragment -LRB- 65-76 -RRB- of monocytic_chemotactic_protein-1 -LRB- MCP-1 -RRB- on the interaction between MCP-1 and heparin .
7542307	0	MCP-1	167,172	MCP-1	216,221	MCP-1	MCP-1	6347	6347	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	IL-1 activation of endothelium supports VLA-4 -LRB- CD49d/CD29 -RRB- - mediated monocyte transendothelial migration to C5a , MIP-1_alpha , RANTES , and PAF but inhibits migration to MCP-1 : a regulatory role for endothelium-derived MCP-1 .
7542307	0	MCP-1	216,221	MCP-1	167,172	MCP-1	MCP-1	6347	6347	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	IL-1 activation of endothelium supports VLA-4 -LRB- CD49d/CD29 -RRB- - mediated monocyte transendothelial migration to C5a , MIP-1_alpha , RANTES , and PAF but inhibits migration to MCP-1 : a regulatory role for endothelium-derived MCP-1 .
25033895	0	MCP-1	0,5	MMP-9	17,22	MCP-1	MMP-9	6347	4318	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MCP-1 stimulates MMP-9 expression via ERK_1 / 2 and p38 MAPK signaling pathways in human aortic smooth muscle cells .
15976326	0	MCP-1	50,55	Mast_cell_tryptase	0,18	MCP-1	Mast cell tryptase	6347	25823	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Mast_cell_tryptase in mast cell granules enhances MCP-1 and interleukin-8 production in human endothelial cells .
10209485	0	MCP-1	36,41	Monocyte_chemoattractant_protein-1	0,34	MCP-1	Monocyte chemoattractant protein-1	6347	6347	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- expression in primary_lymphoepithelioma-like_carcinomas -LRB- LELCs -RRB- of the lung .
15288699	0	MCP-1	36,41	Monocyte_chemoattractant_protein-1	0,34	MCP-1	Monocyte chemoattractant protein-1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene polymorphism and risk of Alzheimer 's _ disease in Italians .
16936342	0	MCP-1	36,41	Monocyte_chemoattractant_protein_1	0,34	MCP-1	Monocyte chemoattractant protein 1	6347	6347	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- gene polymorphism is not associated with severe and cerebral_malaria in Thailand .
8283136	0	MCP-1	36,41	Monocyte_chemoattractant_protein_1	0,34	MCP-1	Monocyte chemoattractant protein 1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- expression occurs in toxic rat liver_injury and human liver_disease .
8679249	0	MCP-1	32,37	Monocyte_chemotactic_protein-1	0,30	MCP-1	Monocyte chemotactic protein-1	6347	6347	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- mRNA is down-regulated in human dermal fibroblasts by dexamethasone : differential regulation by TGF-beta .
10891398	0	MCP-1	69,74	NF-kappa_B	47,57	MCP-1	NF-kappa B	6347	4790	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Macrophages stimulated with IFN-gamma activate NF-kappa_B and induce MCP-1 gene expression in primary human endothelial cells .
25942184	0	MCP-1	83,88	Nox-4	77,82	MCP-1	Nox-4	6347	50507	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Abstract 73 : MicroRNA Regulates Hemangioendothelioma Growth by Targeting the Nox-4 / MCP-1 Pathway .
25942184	0	MCP-1	83,88	Nox-4	77,82	MCP-1	Nox-4	6347	50507	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Abstract 73 : MicroRNA Regulates Hemangioendothelioma Growth by Targeting the Nox-4 / MCP-1 Pathway .
12605701	0	MCP-1	79,84	RANTES	17,23	MCP-1	RANTES	6347	6352	Gene	Gene	levels|compound|START_ENTITY related|nsubjpass|levels elevated|advcl|related elevated|nsubj|END_ENTITY	Monocyte-derived RANTES is intrinsically elevated in periodontal_disease while MCP-1 levels are related to inflammation and are inversely correlated with IL-12 levels .
15631778	0	MCP-1	40,45	RANTES	47,53	MCP-1	RANTES	6347	6352	Gene	Gene	-LSB-|nmod|START_ENTITY -RSB-|advcl|-LSB- -RSB-|nsubj|expression expression|compound|END_ENTITY	-LSB- The role of Cubilin in albumin-induced MCP-1 , RANTES expression by renal tubular epithelial cells -RSB- .
15848524	0	MCP-1	70,75	RANTES	77,83	MCP-1	RANTES	6347	6352	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
22750227	0	MCP-1	8,13	RANTES	0,6	MCP-1	RANTES	6347	6352	Gene	Gene	chemokines|compound|START_ENTITY END_ENTITY|appos|chemokines	RANTES , MCP-1 chemokines and factors describing rheumatoid_arthritis .
15389752	0	MCP-1	0,5	SCYA2	12,17	MCP-1	SCYA2	6347	6347	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	MCP-1 gene -LRB- SCYA2 -RRB- and schizophrenia : a case-control association study .
19923858	0	MCP-1	4,9	SCYA2	16,21	MCP-1	SCYA2	6347	6347	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The MCP-1 gene -LRB- SCYA2 -RRB- and mood_disorders : preliminary results of a case-control association study .
24291552	0	MCP-1	47,52	TGF-b1	32,38	MCP-1	TGF-b1	6347	7040	Gene	Gene	expression|compound|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	Inhibition of KCa3 .1 suppresses TGF-b1 induced MCP-1 expression in human proximal tubular cells through Smad3 , p38 and ERK1/2 signaling pathways .
15848524	0	MCP-1	70,75	TGF-beta	36,44	MCP-1	TGF-beta	6347	7040	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|compound|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
18704440	0	MCP-1	35,40	TGF-beta1	44,53	MCP-1	TGF-beta1	6347	7040	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of mRNA expression of MCP-1 by TGF-beta1 in fibroblast cells from Peyronie 's _ disease .
18490175	0	MCP-1	72,77	THP-1	113,118	MCP-1	THP-1	6347	2736	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nmod|cells cells|compound|END_ENTITY	House dust mite , Dermatophagoides pteronissinus increases expression of MCP-1 , IL-6 , and IL-8 in human monocytic THP-1 cells .
21677444	0	MCP-1	63,68	TLR4	6,10	MCP-1	TLR4	6347	7099	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|compound|END_ENTITY	Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-b in patients with chronic_kidney_disease .
22658637	0	MCP-1	62,67	TNF-a	0,5	MCP-1	TNF-a	6347	7124	Gene	Gene	effects|nmod|START_ENTITY modulates|dobj|effects modulates|nsubj|END_ENTITY	TNF-a modulates statin effects on secretion and expression of MCP-1 , PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes .
24826069	0	MCP-1	17,22	TNF-a	50,55	MCP-1	TNF-a	24770(Tax:10116)	24835(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Retinal neuronal MCP-1 induced by AGEs stimulates TNF-a expression in rat microglia via p38 , ERK , and NF-kB pathways .
25785032	0	MCP-1	59,64	TNF-a	46,51	MCP-1	TNF-a	6347	7124	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Ghrelin inhibits AngII - induced expression of TNF-a , IL-8 , MCP-1 in human umbilical vein endothelial cells .
10331497	0	MCP-1	0,5	TNF-alpha	91,100	MCP-1	TNF-alpha	6347	7124	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|parataxis|plays plays|nsubj|END_ENTITY	MCP-1 is selectively expressed in the late phase by cytokine-stimulated human neutrophils : TNF-alpha plays a role in maximal MCP-1 mRNA expression .
10331497	0	MCP-1	125,130	TNF-alpha	91,100	MCP-1	TNF-alpha	6347	7124	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression plays|dobj|role plays|nsubj|END_ENTITY	MCP-1 is selectively expressed in the late phase by cytokine-stimulated human neutrophils : TNF-alpha plays a role in maximal MCP-1 mRNA expression .
11027549	0	MCP-1	25,30	TNF-alpha	0,9	MCP-1	TNF-alpha	6347	7124	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression stimulation|amod|END_ENTITY	TNF-alpha stimulation of MCP-1 expression is mediated by the Akt/PKB signal transduction pathway in vascular endothelial cells .
12923954	0	MCP-1	40,45	TNF-alpha	47,56	MCP-1	TNF-alpha	6347	7124	Gene	Gene	Il-10|dep|START_ENTITY Il-10|dep|END_ENTITY	-LSB- Selected cytokines -LRB- Il-6 , Il-8 , Il-10 , MCP-1 , TNF-alpha -RRB- in children and adolescents with atherosclerosis risk factors : obesity , hypertension , diabetes -RSB- .
14736953	0	MCP-1	58,63	TNF-alpha	40,49	MCP-1	TNF-alpha	6347	7124	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Dexamethasone regulates AP-1 to repress TNF-alpha induced MCP-1 production in human glomerular endothelial cells .
18976114	0	MCP-1	155,160	TNF-alpha	138,147	MCP-1	TNF-alpha	100360872	24835(Tax:10116)	Gene	Gene	glucose|appos|START_ENTITY glucose|compound|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
19107603	0	MCP-1	68,73	TNF-alpha	50,59	MCP-1	TNF-alpha	6347	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	c-Jun_N-terminal_kinases inhibitor suppresses the TNF-alpha induced MCP-1 expression in human umbilical vein endothelial cells .
19379593	0	MCP-1	25,30	TNF-alpha	12,21	MCP-1	TNF-alpha	6347	7124	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of TNF-alpha on MCP-1 and IL-8 mRNA expression in human umbilical vein endothelial cells -RSB- .
22611924	0	MCP-1	47,52	TNF-alpha	72,81	MCP-1	TNF-alpha	6347	7124	Gene	Gene	expression|nmod|START_ENTITY citreoviridin|nmod|expression Effects|nmod|citreoviridin Effects|acl|induced induced|nmod|END_ENTITY	-LSB- Effects of citreoviridin on the expression of MCP-1 and ILs induced by TNF-alpha in vein endothelial cells -RSB- .
24966899	0	MCP-1	49,54	TSLP	0,4	MCP-1	TSLP	6347	85480	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-kB signal pathways .
26382008	0	MCP-1	0,5	TWEAK	18,23	MCP-1	TWEAK	6347	8742	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	MCP-1 and soluble TWEAK levels are independently associated with coronary_artery_disease severity in patients with chronic_kidney_disease .
12758167	0	MCP-1	14,19	Tat	58,61	MCP-1	Tat	6347	155871(Tax:11676)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells .
20564194	0	MCP-1	94,99	Thrombin	0,8	MCP-1	Thrombin	6347	2147	Gene	Gene	expression|nmod|START_ENTITY GRO|dep|expression motility|nmod|GRO motility|compound|END_ENTITY	Thrombin stimulates RPE cell motility by PKC-zeta - and NF-kappaB-dependent gene expression of MCP-1 and CINC-1 / GRO chemokines .
21787749	0	MCP-1	17,22	Thrombin	0,8	MCP-1	Thrombin	20296(Tax:10090)	14061(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-kB signaling pathway activation in vascular endothelial cells .
20035281	0	MCP-1	36,41	Visfatin	0,8	MCP-1	Visfatin	6347	10135	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Visfatin is a positive regulator of MCP-1 in human adipocytes in vitro and in mice in vivo .
24993819	0	MCP-1	15,20	Wnt5a	34,39	MCP-1	Wnt5a	6347	7474	Gene	Gene	induction|compound|START_ENTITY mediates|dobj|induction mediates|nmod|END_ENTITY	IL-1b mediates MCP-1 induction by Wnt5a in gastric_cancer cells .
21589925	0	MCP-1	0,5	amylin	18,24	MCP-1	amylin	20296(Tax:10090)	15874(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	MCP-1 upregulates amylin expression in murine pancreatic b cells through ERK/JNK-AP 1 and NF-kB related signaling pathways independent of CCR2 .
26045772	0	MCP-1	51,56	miR-98	57,63	MCP-1	miR-98	6347	407054	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	A crosstalk triggered by hypoxia and maintained by MCP-1 / miR-98 / IL-6 / p38 regulatory loop between human aortic smooth muscle cells and macrophages leads to aortic smooth muscle cells apoptosis via Stat1 activation .
10918580	0	MCP-1	83,88	monocyte-chemoattractant_protein-1	47,81	MCP-1	monocyte-chemoattractant protein-1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Differential transcriptional regulation of the monocyte-chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene in tumorigenic and non-tumorigenic HPV 18 positive cells : the role of the chromatin structure and AP-1 composition .
10378384	0	MCP-1	56,61	monocyte_chemoattractant_protein-1	20,54	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Local expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in idiopathic_inflammatory_myopathies .
10759766	0	MCP-1	87,92	monocyte_chemoattractant_protein-1	51,85	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Thromboxane_A2 -LRB- TXA2 -RRB- receptor blockade suppresses monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- expression by stimulated vascular endothelial cells .
17694504	0	MCP-1	171,176	monocyte_chemoattractant_protein-1	135,169	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating advanced glycation end products -LRB- AGEs -RRB- and soluble form of receptor for AGEs -LRB- sRAGE -RRB- are independent determinants of serum monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- levels in patients with type 2 diabetes .
18230355	0	MCP-1	89,94	monocyte_chemoattractant_protein-1	53,87	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the -2518 G/A polymorphism in the monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene and myocardial_infarction in Tunisian patients .
18977211	0	MCP-1	89,94	monocyte_chemoattractant_protein-1	53,87	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the -2518 G/A polymorphism in the monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene and hypertension in Tunisian patients .
22531750	0	MCP-1	58,63	monocyte_chemoattractant_protein-1	22,56	MCP-1	monocyte chemoattractant protein-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of spinal monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in cancer-induced_bone_pain in rats .
23017229	0	MCP-1	160,165	monocyte_chemoattractant_protein-1	124,158	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Genome-wide association replicates the association of Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- polymorphisms with serum monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- levels in Hispanic children .
23375122	0	MCP-1	44,49	monocyte_chemoattractant_protein-1	8,42	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- as an immune-diagnostic biomarker in the pathogenesis of chronic_periodontal_disease .
23930970	0	MCP-1	89,94	monocyte_chemoattractant_protein-1	53,87	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of -2518 A > G promoter polymorphism in the monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene with type_2_diabetes and coronary_artery_disease .
7510962	0	MCP-1	65,70	monocyte_chemoattractant_protein-1	29,63	MCP-1	monocyte chemoattractant protein-1	281043(Tax:9913)	281043(Tax:9913)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Porcine luteal cells express monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- : analysis by polymerase chain reaction and cDNA cloning .
7589574	0	MCP-1	61,66	monocyte_chemoattractant_protein-1	25,59	MCP-1	monocyte chemoattractant protein-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Synergistic induction of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- by platelet-derived growth factor and interleukin-1 .
8195247	0	MCP-1	73,78	monocyte_chemoattractant_protein-1	37,71	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Structure/activity analysis of human monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- by mutagenesis .
8230263	0	MCP-1	58,63	monocyte_chemoattractant_protein-1	22,56	MCP-1	monocyte chemoattractant protein-1	6347	6347	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Quantitative study of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in cerebrospinal fluid and cyst fluid from patients with malignant_glioma .
9227349	0	MCP-1	48,53	monocyte_chemoattractant_protein-1	12,46	MCP-1	monocyte chemoattractant protein-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in the pathogenesis of collagen-induced arthritis in rats .
26429331	0	MCP-1	51,56	monocyte_chemoattractant_protein_1	15,49	MCP-1	monocyte chemoattractant protein 1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- gene polymorphism with lupus_nephritis in Egyptian patients .
8107690	0	MCP-1	48,53	monocyte_chemotactic_protein	18,46	MCP-1	monocyte chemotactic protein	6347	6347	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of monocyte_chemotactic_protein -LRB- MCP-1 -RRB- in human vascular endothelium in vitro and in vivo .
10444270	0	MCP-1	116,121	monocyte_chemotactic_protein-1	84,114	MCP-1	monocyte chemotactic protein-1	6347	6347	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Low-density lipoproteins enhance transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- and monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- expression induced by cyclosporin in human mesangial cells .
10475624	0	MCP-1	67,72	monocyte_chemotactic_protein-1	35,65	MCP-1	monocyte chemotactic protein-1	6347	6347	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive protein expression of monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- by myelomonocytic cell lines and regulation of the secretion by anti- and proinflammatory stimuli .
15552841	0	MCP-1	54,59	monocyte_chemotactic_protein-1	22,52	MCP-1	monocyte chemotactic protein-1	100009130(Tax:9986)	100009130(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Aortic expression of monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- gene in rabbits with experimental atherosclerosis -RSB- .
9927154	0	MCP-1	59,64	monocyte_chemotactic_protein-1	27,57	MCP-1	monocyte chemotactic protein-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- in transforming rat hepatic stellate cells .
19569526	0	MCP-1	110,115	monocytic_chemotaxic_protein-1	78,108	MCP-1	monocytic chemotaxic protein-1	6347	6347	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Development of a new anti-inflammatory peptide preparation -- inhibitor of the monocytic_chemotaxic_protein-1 -LRB- MCP-1 -RRB- -RSB- .
24936866	0	MCP-1	80,85	p65	14,17	MCP-1	p65	6347	5970	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Nuclear NF-kB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1 , RANTES and the severity of type 2 diabetic_nephropathy .
19666473	0	MCP-1	0,5	peroxisome_proliferator-activated_receptor_gamma	153,201	MCP-1	peroxisome proliferator-activated receptor gamma	20296(Tax:10090)	19016(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	MCP-1 -LRB- monocyte_chemotactic_protein-1 -RRB- - induced protein , a recently identified zinc finger protein , induces adipogenesis in 3T3-L1 pre-adipocytes without peroxisome_proliferator-activated_receptor_gamma .
8793801	0	MCP-1	54,59	tumor_necrosis_factor-alpha	8,35	MCP-1	tumor necrosis factor-alpha	6347	7124	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Role of tumor_necrosis_factor-alpha on mesangial cell MCP-1 expression and monocyte migration : mechanisms mediated by signal transduction .
19166999	0	MCP-1	72,77	visfatin	42,50	MCP-1	visfatin	6347	10135	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Pre-B_cell_colony_enhancing_factor -LRB- PBEF -RRB- / visfatin induces secretion of MCP-1 in human endothelial cells : role in visfatin-induced angiogenesis .
9009224	0	MCP-1_receptor	69,83	Monocyte_chemoattractant_protein-2	0,34	MCP-1 receptor	Monocyte chemoattractant protein-2	729230	6355	Gene	Gene	exert|nmod|START_ENTITY exert|nsubj|END_ENTITY	Monocyte_chemoattractant_protein-2 can exert its effects through the MCP-1_receptor -LRB- CC CKR2B -RRB- .
10496322	0	MCP-2	37,42	IFN-gamma	60,69	MCP-2	IFN-gamma	6355	3458	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Transcriptional control of the human MCP-2 gene promoter by IFN-gamma and IL-1beta in connective tissue cells .
20470822	0	MCP-2	26,31	IFN-gamma	0,9	MCP-2	IFN-gamma	6355	3458	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	IFN-gamma , but not IP-10 , MCP-2 or IL-2 response to RD1 selected peptides associates to active_tuberculosis .
20470822	0	MCP-2	26,31	RD1	52,55	MCP-2	RD1	6355	5158	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	IFN-gamma , but not IP-10 , MCP-2 or IL-2 response to RD1 selected peptides associates to active_tuberculosis .
9119400	0	MCP-2	10,15	SCYA8	22,27	MCP-2	SCYA8	6355	6355	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human MCP-2 gene -LRB- SCYA8 -RRB- : cloning , sequence analysis , tissue expression , and assignment to the CC chemokine gene contig on chromosome 17q11 .2 .
17487826	0	MCP-2	104,109	angiotensin_II	65,79	MCP-2	angiotensin II	6355	183	Gene	Gene	induces|dobj|START_ENTITY stimulated|parataxis|induces stimulated|nmod|END_ENTITY	Changes of gene expression profiles in macrophages stimulated by angiotensin_II -- angiotensin_II induces MCP-2 through AT1-receptor .
17487826	0	MCP-2	104,109	angiotensin_II	81,95	MCP-2	angiotensin II	6355	183	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Changes of gene expression profiles in macrophages stimulated by angiotensin_II -- angiotensin_II induces MCP-2 through AT1-receptor .
7999015	0	MCP-2	65,70	monocyte_chemoattractant_protein-2	29,63	MCP-2	monocyte chemoattractant protein-2	281044(Tax:9913)	281044(Tax:9913)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Porcine luteal cells express monocyte_chemoattractant_protein-2 -LRB- MCP-2 -RRB- : analysis by cDNA cloning and northern analysis .
26302185	0	MCP-3	121,126	CCR2	127,131	MCP-3	CCR2	20306(Tax:10090)	12772(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Tissue_factor_pathway_inhibitor gene transfer prevents vascular smooth muscle cell proliferation by interfering with the MCP-3 / CCR2 pathway .
7916328	0	MCP-3	10,15	SCYA7	22,27	MCP-3	SCYA7	6354	6354	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human MCP-3 gene -LRB- SCYA7 -RRB- : cloning , sequence analysis , and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12 .
12439927	0	MCP-3	55,60	monocyte_chemotactic_protein-3	62,92	MCP-3	monocyte chemotactic protein-3	20306(Tax:10090)	20306(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Transfection of colorectal_cancer cells with chemokine MCP-3 -LRB- monocyte_chemotactic_protein-3 -RRB- gene retards_tumor growth and inhibits_tumor metastasis .
9647242	0	MCP-3	98,103	monocyte_chemotactic_protein-3	66,96	MCP-3	monocyte chemotactic protein-3	20306(Tax:10090)	20306(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Reduced tumorigenicity and augmented leukocyte infiltration after monocyte_chemotactic_protein-3 -LRB- MCP-3 -RRB- gene transfer : perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor .
23375121	0	MCP-4	15,20	C-reactive_protein	42,60	MCP-4	C-reactive protein	6357	1401	Gene	Gene	Correlation|nmod|START_ENTITY END_ENTITY|nsubj|Correlation	Correlation of MCP-4 and high-sensitivity C-reactive_protein as a marker of inflammation in obesity and chronic_periodontitis .
10049733	0	MCP-4	84,89	SCYA13	106,112	MCP-4	SCYA13	6357	6357	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization , sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene -LRB- SCYA13 -RRB- in dermal fibroblasts : a comparison to other eosinophilic beta-chemokines .
11400154	0	MCP-4	51,56	monocyte_chemotactic_protein-4	19,49	MCP-4	monocyte chemotactic protein-4	6357	6357	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role for monocyte_chemotactic_protein-4 -LRB- MCP-4 -RRB- in monocyte/macrophage recruitment in acute_renal_inflammation .
20561987	0	MCP-induced_protein_1	0,21	VCAM-1	50,56	MCP-induced protein 1	VCAM-1	80149	7412	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	MCP-induced_protein_1 suppresses TNFalpha-induced VCAM-1 expression in human endothelial cells .
26694804	0	MCP1	163,167	TLR2	128,132	MCP1	TLR2	17224(Tax:10090)	24088(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	A peptide tetramer Tk-tPN induces tolerance of cardiac allo-grafting by conversion of type-1 to type-2 immune responses via the TLR2 signal-promoted activation of MCP1 gene .
7545673	1	MCP3	190,194	C-C_CKR1	83,91	MCP3	C-C CKR1	6354	1230	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	C-C_CKR1 , a receptor for macrophage_inflammatory_protein-1_alpha / Rantes , is also a functional receptor for MCP3 .
19267414	0	MCPH1	41,46	Microcephalin	26,39	MCPH1	Microcephalin	79648	79648	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The c. 940G variant of the Microcephalin -LRB- MCPH1 -RRB- gene is not associated with microcephaly or mental_retardation .
22139841	0	MCPH1	54,59	microcephalin	39,52	MCPH1	microcephalin	79648	79648	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Molecular basis for the association of microcephalin -LRB- MCPH1 -RRB- protein with the cell_division_cycle_protein_27 -LRB- Cdc27 -RRB- subunit of the anaphase-promoting complex .
23185455	0	MCPIP1	0,6	IL-2	22,26	MCPIP1	IL-2	80149	3558	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	MCPIP1 down-regulates IL-2 expression through an ARE-independent pathway .
23551903	0	MCPIP1	36,42	MG-132	21,27	MCPIP1	MG-132	80149	875581(Tax:243273)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Proteasome inhibitor MG-132 induces MCPIP1 expression .
24992982	0	MCPIP1	0,6	MG-132	59,65	MCPIP1	MG-132	80149	875581(Tax:243273)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|toxicity toxicity|nmod|END_ENTITY	MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-kB .
23996627	0	MCR	33,36	melanocortin_receptor	10,31	MCR	melanocortin receptor	4306	4306	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Family of melanocortin_receptor -LRB- MCR -RRB- genes in mammals-mutations , polymorphisms and phenotypic effects .
25728771	0	MCRIP1	0,6	ERK	11,14	MCRIP1	ERK	348262	5594	Gene	Gene	START_ENTITY|appos|Substrate Substrate|compound|END_ENTITY	MCRIP1 , an ERK Substrate , Mediates ERK-Induced Gene Silencing during Epithelial-Mesenchymal Transition by Regulating the Co-Repressor CtBP .
8634143	0	MCS	103,106	mitochondrial_capsule_selenoprotein	61,96	MCS	mitochondrial capsule selenoprotein	24899(Tax:10116)	24899(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning , expression , and chromosomal localization of the rat mitochondrial_capsule_selenoprotein gene -LRB- MCS -RRB- : the reading frame does not contain potential UGA selenocysteine codons .
19537933	0	MCS-18	10,16	capsaicin_receptor	85,103	MCS-18	capsaicin receptor	100302898(Tax:10116)	83810(Tax:10116)	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin_receptor , TRPV1 , in rat cultured sensory neurons .
8833144	0	MCSP	107,111	mitochondrial_capsule_selenoprotein	65,100	MCSP	mitochondrial capsule selenoprotein	4184	4184	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation , expression , and chromosomal localization of the human mitochondrial_capsule_selenoprotein gene -LRB- MCSP -RRB- .
19789340	0	MCT-1	85,90	Extracellular_signal-regulated_kinase	0,37	MCT-1	Extracellular signal-regulated kinase	6566	5594	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase positively regulates the oncogenic activity of MCT-1 in diffuse large B-cell_lymphoma .
21792931	0	MCT1	28,32	Basigin	0,7	MCT1	Basigin	17236(Tax:10090)	12215(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Basigin interacts with both MCT1 and MCT2 in murine spermatozoa .
10921872	0	MCT1	54,58	CD147	0,5	MCT1	CD147	6566	682	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression .
16901736	0	MCT1	53,57	CD147	14,19	MCT1	CD147	780423(Tax:9823)	100141312(Tax:9823)	Gene	Gene	transporters|dobj|START_ENTITY transporters|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD147 and monocarboxylate transporters MCT1 , MCT2 and MCT4 in porcine small intestine and colon .
21930917	0	MCT1	39,43	CD147	0,5	MCT1	CD147	6566	682	Gene	Gene	subunit|nmod|START_ENTITY subunit|nummod|END_ENTITY	CD147 subunit of lactate/H + symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic_tumors .
22281667	0	MCT1	48,52	CD147	73,78	MCT1	CD147	6566	682	Gene	Gene	monocarboxylate_transporter_1|appos|START_ENTITY monocarboxylate_transporter_1|appos|END_ENTITY	Co-expression of monocarboxylate_transporter_1 -LRB- MCT1 -RRB- and its chaperone -LRB- CD147 -RRB- is associated with low survival in patients with gastrointestinal_stromal_tumors -LRB- GISTs -RRB- .
24013424	0	MCT1	34,38	CD147	0,5	MCT1	CD147	6566	682	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CD147 regulates the expression of MCT1 and lactate export in multiple_myeloma cells .
12759536	0	MCT1	45,49	GNA11	22,27	MCT1	GNA11	6566	2767	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of GNA11 and silencing of MCT1 in human breast_cancers .
25281618	0	MCT1	45,49	Monocarboxylate_Transporter-1	14,43	MCT1	Monocarboxylate Transporter-1	6566	6566	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Monocarboxylate_Transporter-1 -LRB- MCT1 -RRB- by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport .
19881260	0	MCT1	26,30	SLC16A1	32,39	MCT1	SLC16A1	6566	6566	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variations in the MCT1 -LRB- SLC16A1 -RRB- gene in the Chinese population of Singapore .
19876643	0	MCT1	78,82	monocarboxylate_transporter	49,76	MCT1	monocarboxylate transporter	6566	6566	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Hypoxia stimulates lactate release and modulates monocarboxylate_transporter -LRB- MCT1 , MCT2 , and MCT4 -RRB- expression in human adipocytes .
22184616	0	MCT1	42,46	monocarboxylate_transporter	14,41	MCT1	monocarboxylate transporter	6566	6566	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulation of monocarboxylate_transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors .
15894023	0	MCT1	62,66	monocarboxylate_transporter_1	31,60	MCT1	monocarboxylate transporter 1	509911(Tax:9913)	509911(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and distribution of monocarboxylate_transporter_1 -LRB- MCT1 -RRB- in the gastrointestinal tract of calves .
18313333	0	MCT1	49,53	monocarboxylate_transporter_1	18,47	MCT1	monocarboxylate transporter 1	6566	6566	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the monocarboxylate_transporter_1 -LRB- MCT1 -RRB- in cells of the porcine intestine .
24166504	0	MCT1	61,65	monocarboxylate_transporter_1	30,59	MCT1	monocarboxylate transporter 1	6566	6566	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucose deprivation increases monocarboxylate_transporter_1 -LRB- MCT1 -RRB- expression and MCT1-dependent tumor cell migration .
25656974	0	MCT1	50,54	monocarboxylate_transporter_1	19,48	MCT1	monocarboxylate transporter 1	6566	6566	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Down-regulation of monocarboxylate_transporter_1 -LRB- MCT1 -RRB- gene expression in the colon of piglets is linked to bacterial protein fermentation and pro-inflammatory cytokine-mediated signalling .
26035357	0	MCT2	48,52	SLC16A7	39,46	MCT2	SLC16A7	9194	9194	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic and oncogenic regulation of SLC16A7 -LRB- MCT2 -RRB- results in protein over-expression , impacting on signalling and cellular phenotypes in prostate_cancer .
12773420	0	MCT2	76,80	monocarboxylate_transporter_2	45,74	MCT2	monocarboxylate transporter 2	20503(Tax:10090)	20503(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Developmental and hormonal regulation of the monocarboxylate_transporter_2 -LRB- MCT2 -RRB- expression in the mouse germ cells .
23417128	0	MCT2	70,74	monocarboxylate_transporters	40,68	MCT2	monocarboxylate transporters	614573(Tax:9913)	614573(Tax:9913)	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Expression and cellular localization of monocarboxylate_transporters -LRB- MCT2 , MCT7 , and MCT8 -RRB- along the cattle gastrointestinal tract .
22240841	0	MCT4	26,30	SLC16A3	32,39	MCT4	SLC16A3	9123	9123	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variations of the MCT4 -LRB- SLC16A3 -RRB- gene in the Chinese and Indian populations of Singapore .
23780984	0	MCT4	85,89	vascular_endothelial_growth_factor	142,176	MCT4	vascular endothelial growth factor	9122	7422	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Expression of monocarboxylate_transporter _ -LRB- MCT -RRB- -4 in colorectal_cancer and its role : MCT4 contributes to the growth of colorectal_cancer with vascular_endothelial_growth_factor .
22535767	0	MCT8	82,86	PTTG-binding_factor	0,19	MCT8	PTTG-binding factor	20502(Tax:10090)	108705(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PTTG-binding_factor -LRB- PBF -RRB- is a novel regulator of the thyroid hormone transporter MCT8 .
18636565	0	MCT8	60,64	SLC16A2	66,73	MCT8	SLC16A2	6567	6567	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 -LRB- SLC16A2 -RRB- mutations .
24815697	0	MCU	57,60	ERp57	0,5	MCU	ERp57	90550	2923	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	ERp57 modulates mitochondrial calcium uptake through the MCU .
24339336	0	MD-2	29,33	CD14	14,18	MD-2	CD14	17087(Tax:10090)	12475(Tax:10090)	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Modulation of CD14 and TLR4 MD-2 activities by a synthetic lipid A mimetic .
19109192	0	MD-2	15,19	IL-10	0,5	MD-2	IL-10	23643	3586	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients .
25049357	0	MD-2	11,15	PTX3	0,4	MD-2	PTX3	17087(Tax:10090)	19288(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis .
24858600	0	MD-2	16,20	STAT1	0,5	MD-2	STAT1	23643	6772	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a .
16303092	0	MD-2	20,24	TLR-4	14,19	MD-2	TLR-4	23643	7099	Gene	Gene	signaling|nsubj|START_ENTITY Inhibition|parataxis|signaling Inhibition|nmod|END_ENTITY	Inhibition of TLR-4 / MD-2 signaling by RP105/MD -1 .
12496426	0	MD-2	24,28	TLR4	193,197	MD-2	TLR4	17087(Tax:10090)	21898(Tax:10090)	Gene	Gene	residues|compound|START_ENTITY Identification|nmod|residues recognized|nsubj|Identification recognized|nmod|END_ENTITY	Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies , and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis .
15184344	0	MD-2	104,108	TLR4	128,132	MD-2	TLR4	23643	7099	Gene	Gene	oligomerization|compound|START_ENTITY oligomerization|compound|END_ENTITY	Lipid_A antagonist , lipid IVa , is distinct from lipid_A in interaction with Toll-like_receptor_4 -LRB- TLR4 -RRB- - MD-2 and ligand-induced TLR4 oligomerization .
15184344	0	MD-2	104,108	TLR4	98,102	MD-2	TLR4	23643	7099	Gene	Gene	oligomerization|compound|START_ENTITY Toll-like_receptor_4|dep|oligomerization Toll-like_receptor_4|appos|END_ENTITY	Lipid_A antagonist , lipid IVa , is distinct from lipid_A in interaction with Toll-like_receptor_4 -LRB- TLR4 -RRB- - MD-2 and ligand-induced TLR4 oligomerization .
15557191	0	MD-2	74,78	TLR4	57,61	MD-2	TLR4	23643	29260(Tax:10116)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling .
16272300	0	MD-2	96,100	TLR4	79,83	MD-2	TLR4	23643	7099	Gene	Gene	coreceptor|appos|START_ENTITY coreceptor|compound|END_ENTITY	Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor , MD-2 .
16946018	0	MD-2	0,4	TLR4	84,88	MD-2	TLR4	23643	7099	Gene	Gene	expression|compound|START_ENTITY required|nsubjpass|expression required|nmod|surface surface|acl|targeting targeting|nmod|Toll-like_receptor_4 Toll-like_receptor_4|appos|END_ENTITY	MD-2 expression is not required for cell surface targeting of Toll-like_receptor_4 -LRB- TLR4 -RRB- .
17217428	0	MD-2	120,124	TLR4	84,88	MD-2	TLR4	23643	7099	Gene	Gene	site|compound|START_ENTITY block|nmod|site block|nmod|END_ENTITY	Antagonistic lipopolysaccharides block E. _ coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site .
17545685	0	MD-2	6,10	TLR4	80,84	MD-2	TLR4	23643	7099	Gene	Gene	discrimination|compound|START_ENTITY discrimination|nmod|END_ENTITY	Human MD-2 discrimination of meningococcal lipid_A structures and activation of TLR4 .
18203953	0	MD-2	42,46	TLR4	90,94	MD-2	TLR4	17087(Tax:10090)	21898(Tax:10090)	Gene	Gene	Phagocytosis|nmod|START_ENTITY opsonized|nsubj|Phagocytosis opsonized|ccomp|depend depend|nmod|signaling signaling|compound|END_ENTITY	Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling .
18424732	0	MD-2	23,27	TLR4	167,171	MD-2	TLR4	23643	7099	Gene	Gene	variant|compound|START_ENTITY activity|nmod|variant different|nsubj|activity different|nmod|forms forms|dep|endotoxin endotoxin|nmod|ectodomain ectodomain|compound|END_ENTITY	Functional activity of MD-2 polymorphic variant is significantly different in soluble and TLR4-bound forms : decreased endotoxin binding by G56R MD-2 and its rescue by TLR4 ectodomain .
18977229	0	MD-2	51,55	TLR4	22,26	MD-2	TLR4	23643	7099	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Taxanes inhibit human TLR4 signaling by binding to MD-2 .
20212095	0	MD-2	97,101	TLR4	122,126	MD-2	TLR4	23643	7099	Gene	Gene	coexpression|nmod|START_ENTITY depends|nmod|coexpression depends|advcl|does does|dobj|END_ENTITY	Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4 .
20212095	0	MD-2	97,101	TLR4	60,64	MD-2	TLR4	23643	7099	Gene	Gene	coexpression|nmod|START_ENTITY depends|nmod|coexpression depends|nsubj|Expression Expression|nmod|variant variant|nmod|END_ENTITY	Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4 .
20435923	0	MD-2	32,36	TLR4	105,109	MD-2	TLR4	23643	7099	Gene	Gene	Identification|nmod|START_ENTITY splice|nsubj|Identification splice|dobj|variant variant|acl:relcl|regulates regulates|dobj|END_ENTITY	Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling .
21402551	0	MD-2	0,4	TLR4	83,87	MD-2	TLR4	23643	7099	Gene	Gene	chalcone|nsubj|START_ENTITY chalcone|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity .
23439691	0	MD-2	33,37	TLR4	100,104	MD-2	TLR4	23643	7099	Gene	Gene	complex|compound|START_ENTITY Radioiodination|nmod|complex generates|nsubj|Radioiodination generates|nmod|END_ENTITY	Radioiodination of an endotoxin MD-2 complex generates a novel sensitive , high-affinity ligand for TLR4 .
24688705	0	MD-2	81,85	TLR4	74,78	MD-2	TLR4	23643	100066890(Tax:9796)	Gene	Gene	complexes|compound|START_ENTITY complexes|dep|Reviewing Reviewing|dobj|amino_acids amino_acids|nmod|END_ENTITY	Reviewing and identifying amino_acids of human , murine , canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid _ A , or antagonistic effects by Eritoran , in contrast to species-dependent modulation by lipid IVa .
25037631	0	MD-2	86,90	TLR4	91,95	MD-2	TLR4	17087(Tax:10090)	7099	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The molecular mechanism of species-specific recognition of lipopolysaccharides by the MD-2 / TLR4 receptor complex .
25203747	0	MD-2	98,102	TLR4	31,35	MD-2	TLR4	17087(Tax:10090)	21898(Tax:10090)	Gene	Gene	residues|nmod|START_ENTITY governed|nmod|residues governed|nsubj|activation activation|nmod|END_ENTITY	Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2 .
25394365	0	MD-2	55,59	TLR4	61,65	MD-2	TLR4	23643	7099	Gene	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Anti-endotoxic activity and structural basis for human MD-2 TLR4 antagonism of tetraacylated_lipid_A mimetics based on bGlcN -LRB- 1 1 -RRB- aGlcN scaffold .
25559892	0	MD-2	0,4	TLR4	47,51	MD-2	TLR4	17087(Tax:10090)	21898(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|signaling signaling|compound|END_ENTITY	MD-2 is required for disulfide HMGB1-dependent TLR4 signaling .
25803856	0	MD-2	0,4	TLR4	68,72	MD-2	TLR4	23643	7099	Gene	Gene	Determinants|compound|START_ENTITY Determinants|nmod|END_ENTITY	MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4 .
26160169	0	MD-2	83,87	TLR4	42,46	MD-2	TLR4	23643	7099	Gene	Gene	Myeloid_Differentiation_Factor_2|appos|START_ENTITY Myeloid_Differentiation_Factor_2|appos|END_ENTITY	Activation of Human Toll-like_Receptor_4 -LRB- TLR4 -RRB- Myeloid_Differentiation_Factor_2 -LRB- MD-2 -RRB- by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia_cenocepacia .
26330549	0	MD-2	17,21	TLR4	46,50	MD-2	TLR4	17087(Tax:10090)	21898(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Gedunin Binds to MD-2 and Impairs LPS-Induced TLR4 Signaling in Macrophages .
24858600	0	MD-2	16,20	miR-30a	59,66	MD-2	miR-30a	23643	407029	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a .
18845299	0	MD2	8,11	TLR4	22,26	MD2	TLR4	23643	7099	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|levels levels|nummod|END_ENTITY	Soluble MD2 increases TLR4 levels on the epithelial cell surface .
12907144	0	MDA-7	17,22	IL-24	23,28	MDA-7	IL-24	170819(Tax:10116)	170819(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	Tumor suppressor MDA-7 / IL-24 selectively inhibits vascular smooth_muscle_cell growth and migration .
15709189	0	MDA-7	14,19	IL-24	20,25	MDA-7	IL-24	11009	11009	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of MDA-7 / IL-24 and its clinical significance in resected non-small cell lung_cancer .
15880678	0	MDA-7	0,5	IL-24	6,11	MDA-7	IL-24	11009	11009	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	MDA-7 / IL-24 regulates proliferation , invasion and tumor cell radiosensitivity : a new cancer therapy ?
16710719	0	MDA-7	22,27	IL-24	28,33	MDA-7	IL-24	11009	11009	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Human interleukin_24 -LRB- MDA-7 / IL-24 -RRB- protein kills breast_cancer cells via the IL-20 receptor and is antagonized by IL-10 .
16912197	0	MDA-7	41,46	IL-24	47,52	MDA-7	IL-24	11009	11009	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	BiP/GRP78 is an intracellular target for MDA-7 / IL-24 induction of cancer-specific apoptosis .
16995981	0	MDA-7	30,35	IL-24	36,41	MDA-7	IL-24	11009	11009	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	-LSB- Adenovirus vector expressing MDA-7 / IL-24 selectively induces growth arrests and apoptosis in human hepatocellular_carcinoma cell lines independent of the state of p53 gene -RSB- .
17828282	0	MDA-7	132,137	IL-24	138,143	MDA-7	IL-24	11009	11009	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	MDA-7 / IL-24 , a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin-proteasome system , and inhibition of MDA-7 / IL-24 degradation enhances the antitumor activity .
18278464	0	MDA-7	51,56	IL-24	57,62	MDA-7	IL-24	11009	11009	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Replication-incompetent adenovirus vector-mediated MDA-7 / IL-24 selectively induces growth suppression and apoptosis of hepatoma cell Line SMMC-7721 .
22588557	0	MDA-7	62,67	IL-24	68,73	MDA-7	IL-24	11009	11009	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	A novel oncogenic pathway by TLS-CHOP involving repression of MDA-7 / IL-24 expression .
22629368	0	MDA-7	0,5	IL-24	6,11	MDA-7	IL-24	11009	11009	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|END_ENTITY	MDA-7 / IL-24 induces Bcl-2 denitrosylation and ubiquitin-degradation involved in cancer cell apoptosis .
26474456	0	MDA-7	0,5	IL-24	6,11	MDA-7	IL-24	93672(Tax:10090)	93672(Tax:10090)	Gene	Gene	START_ENTITY|dep|functions functions|compound|END_ENTITY	MDA-7 / IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast_cancer .
12907143	0	MDA-7	0,5	beta-catenin	31,43	MDA-7	beta-catenin	11009	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast_and_lung_tumor cells .
12533668	0	MDA-7	135,140	iNOS	151,155	MDA-7	iNOS	11009	4843	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Negative association of melanoma differentiation-associated gene -LRB- mda-7 -RRB- and inducible nitric_oxide synthase -LRB- iNOS -RRB- in human melanoma : MDA-7 regulates iNOS expression in melanoma cells .
18046450	0	MDA-7	95,100	interleukin-24	101,115	MDA-7	interleukin-24	11009	11009	Gene	Gene	/|compound|START_ENTITY /|amod|END_ENTITY	Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7 / interleukin-24 for B-lymphoblastic_leukemia via induction of apoptosis .
16710719	0	MDA-7	22,27	interleukin_24	6,20	MDA-7	interleukin 24	11009	11009	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Human interleukin_24 -LRB- MDA-7 / IL-24 -RRB- protein kills breast_cancer cells via the IL-20 receptor and is antagonized by IL-10 .
25593999	0	MDA-9	0,5	Syntenin	6,14	MDA-9	Syntenin	6386	6386	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	MDA-9 / Syntenin regulates differentiation and angiogenesis programs in head_and_neck_squamous_cell_carcinoma .
23684765	0	MDA5	0,4	CXCL10	23,29	MDA5	CXCL10	64135	3627	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MDA5 and ISG56 mediate CXCL10 expression induced by toll-like_receptor_4 activation in U373MG human astrocytoma cells .
24800889	0	MDA5	100,104	interferon_regulatory_factor_3	24,54	MDA5	interferon regulatory factor 3	64135	3661	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|activation activation|nmod|END_ENTITY	Sustained activation of interferon_regulatory_factor_3 during infection by paramyxoviruses requires MDA5 .
22459580	0	MDA5	72,76	melanoma_differentiation-associated_gene_5	28,70	MDA5	melanoma differentiation-associated gene 5	424185(Tax:9031)	424185(Tax:9031)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of chicken melanoma_differentiation-associated_gene_5 -LRB- MDA5 -RRB- from alternative translation initiation .
26504669	0	MDA5	70,74	melanoma_differentiation-associated_protein_5	23,68	MDA5	melanoma differentiation-associated protein 5	71586(Tax:10090)	71586(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Targeted activation of melanoma_differentiation-associated_protein_5 -LRB- MDA5 -RRB- for immunotherapy of pancreatic_carcinoma .
24046408	0	MDA5	102,106	melanoma_differentiation_associated_gene_5	58,100	MDA5	melanoma differentiation associated gene 5	64135	64135	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Identification and expression profiling analysis of goose melanoma_differentiation_associated_gene_5 -LRB- MDA5 -RRB- gene .
24361916	0	MDA7	73,77	CB2	60,63	MDA7	CB2	170819(Tax:10116)	57302(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Spinal gene expression profiling and pathways analysis of a CB2 agonist -LRB- MDA7 -RRB- - targeted prevention of paclitaxel-induced neuropathy .
12629149	0	MDC	19,22	CCL22	12,17	MDC	CCL22	20299(Tax:10090)	20299(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of CCL22 -LRB- MDC -RRB- for the recruitment of eosinophils during allergic_pleurisy in mice .
11876749	0	MDC	36,39	macrophage-derived_chemokine	6,34	MDC	macrophage-derived chemokine	6367	6367	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum macrophage-derived_chemokine -LRB- MDC -RRB- levels are closely related with the disease activity of atopic_dermatitis .
9581805	0	MDC	44,47	macrophage-derived_chemokine	14,42	MDC	macrophage-derived chemokine	6367	6367	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of macrophage-derived_chemokine -LRB- MDC -RRB- mRNA in macrophages is enhanced by interleukin-1beta , tumor_necrosis_factor_alpha , and lipopolysaccharide .
16377563	0	MDC1	0,4	H2AX	43,47	MDC1	H2AX	9656	3014	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks .
20521098	0	MDC1	45,49	Mediator_of_DNA_damage_checkpoint_protein_1	0,43	MDC1	Mediator of DNA damage checkpoint protein 1	9656	9656	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mediator_of_DNA_damage_checkpoint_protein_1 -LRB- MDC1 -RRB- expression as a prognostic marker for nodal recurrence in early-stage_breast_cancer patients treated with breast-conserving surgery and radiation therapy .
18678890	0	MDC1	0,4	NBS1	53,57	MDC1	NBS1	9656	4683	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks .
21857162	0	MDC1	53,57	RAP80	76,81	MDC1	RAP80	9656	51720	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Recruitment of proteins to DNA double-strand breaks : MDC1 directly recruits RAP80 .
16186822	0	MDC1	0,4	Rad51	20,25	MDC1	Rad51	9656	5888	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MDC1 interacts with Rad51 and facilitates homologous recombination .
21482717	0	MDC1	0,4	TopBP1	23,29	MDC1	TopBP1	9656	11073	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	MDC1 collaborates with TopBP1 in DNA replication checkpoint control .
10527948	0	MDC9	189,193	MAD2beta	229,237	MDC9	MAD2beta	8754	10459	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Evidence for an interaction of the metalloprotease-disintegrin tumour_necrosis_factor_alpha_convertase -LRB- TACE -RRB- with mitotic_arrest_deficient_2 -LRB- MAD2 -RRB- , and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein , MAD2beta .
2091050	0	MDGI	90,94	mammary_derived_growth_inhibitor	56,88	MDGI	mammary derived growth inhibitor	281758(Tax:9913)	281758(Tax:9913)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Characterization and function dependent localization of mammary_derived_growth_inhibitor -LRB- MDGI -RRB- in mammary glands of bovine and mice .
11169757	0	MDH2	98,102	Cat8	0,4	MDH2	Cat8	853994(Tax:4932)	855323(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	Cat8 and Sip4 mediate regulated transcriptional activation of the yeast malate dehydrogenase gene MDH2 by three carbon source-responsive promoter elements .
9299784	0	MDH2	50,54	malate_dehydrogenase	28,48	MDH2	malate dehydrogenase	853994(Tax:4932)	853994(Tax:4932)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of cytosolic malate_dehydrogenase -LRB- MDH2 -RRB- causes overproduction of specific organic acids in Saccharomyces_cerevisiae .
9010230	0	MDK1	90,94	Elf-1	18,23	MDK1	Elf-1	13841(Tax:10090)	13709(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Elf-1 and B61 as high affinity ligands for the receptor_tyrosine_kinase MDK1 .
7115281	0	MDL-1	65,70	malate_dehydrogenase-like_enzyme	31,63	MDL-1	malate dehydrogenase-like enzyme	24551(Tax:10116)	24551(Tax:10116)	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	A new genetic variation of the malate_dehydrogenase-like_enzyme -LRB- MDL-1 -RRB- in inbred rats and its possible linkage .
7619220	0	MDM-2	18,23	p53	49,52	MDM-2	p53	4193	7157	Gene	Gene	mRNA|compound|START_ENTITY Overexpression|nmod|mRNA Overexpression|nmod|gene gene|compound|END_ENTITY	Overexpression of MDM-2 mRNA and mutation of the p53 tumor suppressor gene in bladder_carcinoma cell lines .
8297484	0	MDM-2	11,16	p53	83,86	MDM-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Absence|nmod|gene amplification|nsubj|Absence amplification|nmod|status status|compound|END_ENTITY	Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status .
9267820	0	MDM-2	0,5	p53	98,101	MDM-2	p53	4193	7157	Gene	Gene	overexpression|compound|START_ENTITY overexpression|dep|association association|nmod|accumulation accumulation|compound|END_ENTITY	MDM-2 oncoprotein overexpression in laryngeal_squamous_cell_carcinoma : association with wild-type p53 accumulation .
16982679	0	MDM2	0,4	Akt1	59,63	MDM2	Akt1	17246(Tax:10090)	11651(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells .
10398121	0	MDM2	93,97	CDK4	83,87	MDM2	CDK4	4193	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
11505267	0	MDM2	0,4	CDK4	6,10	MDM2	CDK4	4193	1019	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	MDM2 + / CDK4 + / p53 + oral_liposarcoma : case report and review of the literature .
18214854	0	MDM2	24,28	CDK4	94,98	MDM2	CDK4	4193	1019	Gene	Gene	partner|nmod|START_ENTITY partner|advcl|belongs belongs|nsubj|END_ENTITY	HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated_liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon .
25803170	0	MDM2	0,4	CDK4	107,111	MDM2	CDK4	4193	1019	Gene	Gene	turnover|compound|START_ENTITY determine|nsubj|turnover determine|nmod|inhibition inhibition|compound|END_ENTITY	MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition .
8221695	0	MDM2	38,42	CDK4	23,27	MDM2	CDK4	4193	1019	Gene	Gene	Coamplification|nmod|START_ENTITY Coamplification|nmod|gene gene|compound|END_ENTITY	Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas .
11284721	0	MDM2	49,53	CK2	95,98	MDM2	CK2	17246(Tax:10090)	13000(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Phosphorylation of murine double minute clone 2 -LRB- MDM2 -RRB- protein at serine-267 by protein kinase CK2 in vitro and in cultured cells .
24361594	0	MDM2	18,22	DNAJB1	0,6	MDM2	DNAJB1	4193	3337	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner .
15364927	0	MDM2	68,72	Daxx	40,44	MDM2	Daxx	4193	1616	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of p53 functions by Daxx and the involvement of MDM2 .
19638586	0	MDM2	20,24	HIPK2	0,5	MDM2	HIPK2	4193	28996	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating_drugs_nutlin-3_and_RITA .
21478269	0	MDM2	38,42	HSP90	55,60	MDM2	HSP90	4193	3320	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells .
19648273	0	MDM2	34,38	IFN_regulatory_factor_8	0,23	MDM2	IFN regulatory factor 8	17246(Tax:10090)	15900(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IFN_regulatory_factor_8 regulates MDM2 in germinal center B cells .
21093410	0	MDM2	0,4	Itch	78,82	MDM2	Itch	4193	83737	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|interaction interaction|nmod|END_ENTITY	MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells .
16107876	0	MDM2	0,4	KAP1	42,46	MDM2	KAP1	4193	10155	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation .
14612427	0	MDM2	55,59	L11	18,21	MDM2	L11	4193	6135	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway .
26001071	0	MDM2	38,42	MDM4	99,103	MDM2	MDM4	4193	4194	Gene	Gene	Function|compound|START_ENTITY Function|nmod|END_ENTITY	MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4 .
10218570	0	MDM2	0,4	MDMX	20,24	MDM2	MDMX	4193	4194	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MDM2 interacts with MDMX through their RING finger domains .
10608892	0	MDM2	21,25	MDMX	83,87	MDM2	MDMX	4193	4194	Gene	Gene	Stabilization|nmod|START_ENTITY oncoprotein|nsubj|Stabilization oncoprotein|nmod|protein protein|compound|END_ENTITY	Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein .
12860999	0	MDM2	0,4	MDMX	48,52	MDM2	MDMX	4193	4194	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	MDM2 promotes ubiquitination and degradation of MDMX .
12963717	0	MDM2	51,55	MDMX	19,23	MDM2	MDMX	4193	4194	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|degradation degradation|compound|END_ENTITY	DNA damage-induced MDMX degradation is mediated by MDM2 .
16905541	0	MDM2	51,55	MDMX	0,4	MDM2	MDMX	4193	4194	Gene	Gene	Nutlin|compound|START_ENTITY prevents|nmod|Nutlin prevents|nsubj|overexpression overexpression|compound|END_ENTITY	MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin .
17159902	0	MDM2	51,55	MDMX	75,79	MDM2	MDMX	4193	4194	Gene	Gene	C-terminus|nmod|START_ENTITY function|nmod|C-terminus provided|nsubjpass|function provided|nmod|END_ENTITY	An essential function of the extreme C-terminus of MDM2 can be provided by MDMX .
18520179	0	MDM2	9,13	MDMX	91,95	MDM2	MDMX	4193	4194	Gene	Gene	boosts|nsubj|START_ENTITY boosts|advcl|facilitating facilitating|dobj|degradation degradation|compound|END_ENTITY	Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation .
25659040	0	MDM2	55,59	MDMX	27,31	MDM2	MDMX	4193	4194	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|isoform isoform|compound|END_ENTITY	The alternative translated MDMX -LRB- p60 -RRB- isoform regulates MDM2 activity .
8895579	0	MDM2	69,73	MDMX	0,4	MDM2	MDMX	4193	4194	Gene	Gene	properties|nmod|START_ENTITY protein|nmod|properties END_ENTITY|dep|protein	MDMX : a novel p53-binding protein with some functional properties of MDM2 .
15644444	0	MDM2	24,28	MYCN	67,71	MDM2	MYCN	4193	4613	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma .
15917661	0	MDM2	0,4	MYCN	35,39	MDM2	MYCN	17246(Tax:10090)	18109(Tax:10090)	Gene	Gene	START_ENTITY|nmod|effector effector|nmod|oncogene oncogene|compound|END_ENTITY	MDM2 as a critical effector of the MYCN oncogene in tumorigenesis .
15927364	0	MDM2	0,4	MYCN	8,12	MDM2	MYCN	17246(Tax:10090)	18109(Tax:10090)	Gene	Gene	START_ENTITY|nmod|target target|compound|END_ENTITY	MDM2 as MYCN transcriptional target : implications for neuroblastoma pathogenesis .
21822304	0	MDM2	0,4	MYCN	15,19	MDM2	MYCN	4193	4613	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stabilization stabilization|compound|END_ENTITY	MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells .
19308274	0	MDM2	42,46	Murine_Double_Minute_2	18,40	MDM2	Murine Double Minute 2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	The Expression of Murine_Double_Minute_2 -LRB- MDM2 -RRB- on Helicobacter_pylori-Infected Intestinal_Metaplasia and Gastric_Cancer .
24413661	0	MDM2	81,85	NIR	26,29	MDM2	NIR	4193	26155	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2 .
21504894	0	MDM2	0,4	NME2	20,24	MDM2	NME2	4193	4831	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MDM2 interacts with NME2 -LRB- non-metastatic_cells_2 , protein -RRB- and suppresses the ability of NME2 to negatively regulate cell motility .
23252402	0	MDM2	71,75	Notch1	38,44	MDM2	Notch1	17246(Tax:10090)	18128(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway .
23167335	0	MDM2	0,4	P21	41,44	MDM2	P21	4193	644914	Gene	Gene	T309G|compound|START_ENTITY has|nsubj|T309G has|dobj|effect effect|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	MDM2 T309G has a synergistic effect with P21 ser31arg single nucleotide polymorphisms on the risk of acute_myeloid_leukemia .
11400116	0	MDM2	96,100	P53	30,33	MDM2	P53	4193	7157	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|distribution distribution|nmod|immunoreactivity immunoreactivity|nummod|END_ENTITY	Heterogeneous distribution of P53 immunoreactivity in human lung_adenocarcinoma correlates with MDM2 protein expression , rather than with P53 gene mutation .
16696307	0	MDM2	36,40	P53	0,3	MDM2	P53	4193	7157	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	P53 gene mutation and expression of MDM2 , P53 , P16 protein and their relationship in human glioma .
17120736	0	MDM2	54,58	P53	0,3	MDM2	P53	4193	7157	Gene	Gene	blockage|nmod|START_ENTITY regulation|nmod|blockage regulation|nummod|END_ENTITY	P53 regulation of leukemia cells with the blockage of MDM2 by antisense oligonucleotides .
20156327	0	MDM2	93,97	P53	73,76	MDM2	P53	4193	7157	Gene	Gene	R72P|nmod|START_ENTITY R72P|nmod|END_ENTITY	Have the roles of two functional polymorphisms in breast_cancer , R72P in P53 and MDM2-309 in MDM2 , become clearer ?
23084521	0	MDM2	14,18	P53	44,47	MDM2	P53	4193	7157	Gene	Gene	RG7112|compound|START_ENTITY RG7112|nmod|pathway pathway|compound|END_ENTITY	Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified , well-differentiated or dedifferentiated liposarcoma : an exploratory proof-of-mechanism study .
19833129	0	MDM2	34,38	Polo-like_kinase-1	0,18	MDM2	Polo-like kinase-1	4193	5347	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Polo-like_kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover .
26926424	0	MDM2	80,84	RNF12	0,5	MDM2	RNF12	4193	51132	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction .
26220995	0	MDM2	19,23	RPL11	39,44	MDM2	RPL11	4193	6135	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
26220995	0	MDM2	19,23	RPL11	39,44	MDM2	RPL11	4193	6135	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
10611293	0	MDM2	80,84	TAF	42,45	MDM2	TAF	4193	129685	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	The alpha-helical FXXPhiPhi motif in p53 : TAF interaction and discrimination by MDM2 .
9856953	0	MDM2	24,28	TGF-beta1	32,41	MDM2	TGF-beta1	4193	7040	Gene	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	p53-independent role of MDM2 in TGF-beta1 resistance .
10329038	0	MDM2	64,68	TP53	58,62	MDM2	TP53	4193	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	MDM2	93,97	TP53	0,4	MDM2	TP53	4193	7157	Gene	Gene	proteins|nummod|START_ENTITY cycle-associated|xcomp|proteins cell|acl|cycle-associated alterations|nmod|cell alterations|nsubj|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
18262501	0	MDM2	13,17	TP53	58,62	MDM2	TP53	4193	7157	Gene	Gene	SNP309|compound|START_ENTITY Influence|nmod|SNP309 Influence|nmod|polymorphism polymorphism|compound|END_ENTITY	Influence of MDM2 SNP309 alone or in combination with the TP53 R72P polymorphism in oligodendroglial_tumors .
18462472	0	MDM2	28,32	TP53	77,81	MDM2	TP53	4193	7157	Gene	Gene	genes|compound|START_ENTITY polymorphisms|nmod|genes polymorphisms|nmod|mutations mutations|nummod|END_ENTITY	Common polymorphisms in the MDM2 and TP53 genes and the relationship between TP53 mutations and patient outcomes in glioblastomas .
19541936	0	MDM2	94,98	TP53	77,81	MDM2	TP53	17246(Tax:10090)	22059(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression essential|xcomp|regulate essential|nmod|END_ENTITY	NOLC1 , an enhancer of nasopharyngeal_carcinoma progression , is essential for TP53 to regulate MDM2 expression .
20520810	0	MDM2	11,15	TP53	102,106	MDM2	TP53	4193	7157	Gene	Gene	Effects|nmod|START_ENTITY codon|nsubj|Effects codon|dobj|polymorphisms polymorphisms|nmod|risk risk|nmod|study study|nmod|carriers carriers|nmod|mutations mutations|nummod|END_ENTITY	Effects of MDM2 , MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations .
23982177	0	MDM2	0,4	TP53	55,59	MDM2	TP53	4193	7157	Gene	Gene	phenotypic|compound|START_ENTITY phenotypic|appos|status status|nummod|END_ENTITY	MDM2 phenotypic and genotypic profiling , respective to TP53 genetic status , in diffuse_large_B-cell_lymphoma patients treated with rituximab-CHOP immunochemotherapy : a report from the International DLBCL Rituximab-CHOP Consortium Program .
25621298	0	MDM2	78,82	TP53	116,120	MDM2	TP53	4193	7157	Gene	Gene	combined|nmod|START_ENTITY combined|nmod|cells cells|nmod|mutation mutation|compound|END_ENTITY	MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation .
25621298	0	MDM2	78,82	TP53	35,39	MDM2	TP53	4193	7157	Gene	Gene	combined|nmod|START_ENTITY reactivation|nmod|combined reactivation|nsubj|expression expression|nmod|indicator indicator|nmod|END_ENTITY	MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation .
25842826	0	MDM2	66,70	TP53	48,52	MDM2	TP53	4193	7157	Gene	Gene	genes|nummod|START_ENTITY Association|nmod|genes Association|nmod|END_ENTITY	-LSB- Association of polymorphic markers Arg72Pro of TP53 and T309g of MDM2 genes with non_small_cell_lung_cancer in Russians of Moscow region -RSB- .
7547235	0	MDM2	0,4	TP53	65,69	MDM2	TP53	4193	7157	Gene	Gene	overexpression|compound|START_ENTITY rare|nsubj|overexpression rare|nmod|irrespective irrespective|nmod|status status|compound|END_ENTITY	MDM2 overexpression is rare in ovarian_carcinoma irrespective of TP53 mutation status .
8721685	0	MDM2	66,70	TP53	28,32	MDM2	TP53	4193	7157	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene mutations|nmod|gene gene|compound|END_ENTITY	Infrequent mutations of the TP53 gene and no amplification of the MDM2 gene in hepatoblastomas .
9120719	0	MDM2	77,81	TP53	0,4	MDM2	TP53	4193	7157	Gene	Gene	overexpression|nmod|START_ENTITY relation|nmod|overexpression accumulation|nmod|relation accumulation|compound|END_ENTITY	TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein_in_ovarian_borderline_tumours_and_stage_I_carcinomas .
24777531	0	MDM2	17,21	USP15	0,5	MDM2	USP15	4193	9958	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses .
10329038	0	MDM2	64,68	cdk4	80,84	MDM2	cdk4	4193	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10329038	0	MDM2	64,68	cyclin_D1	86,95	MDM2	cyclin D1	4193	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	MDM2	93,97	cyclin_D1	72,81	MDM2	cyclin D1	4193	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
24870800	0	MDM2	24,28	cyclin_D1	73,82	MDM2	cyclin D1	4193	595	Gene	Gene	promoter|compound|START_ENTITY SNP|nmod|promoter mediates|nsubj|SNP mediates|xcomp|modulate modulate|dobj|expression expression|amod|END_ENTITY	A functional SNP in the MDM2 promoter mediates E2F1 affinity to modulate cyclin_D1 expression in tumor cell proliferation .
18451149	0	MDM2	0,4	dihydrofolate_reductase	15,38	MDM2	dihydrofolate reductase	4193	1719	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	MDM2 regulates dihydrofolate_reductase activity through monoubiquitination .
18433484	0	MDM2	89,93	murine_double_minute-2	65,87	MDM2	murine double minute-2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Early onset lung_cancer , cigarette smoking and the SNP309 of the murine_double_minute-2 -LRB- MDM2 -RRB- gene .
12085228	0	MDM2	73,77	p14ARF	43,49	MDM2	p14ARF	4193	1029	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2 .
26509911	0	MDM2	45,49	p16	0,3	MDM2	p16	4193	1029	Gene	Gene	Useful|nmod|START_ENTITY Useful|nsubj|Immunohistochemistry Immunohistochemistry|compound|END_ENTITY	p16 Immunohistochemistry is Less Useful Than MDM2 and CDK4 to Distinguish Dedifferentiated_Liposarcomas From Other Retroperitoneal Mimics .
11753042	0	MDM2	100,104	p16INK4a	0,8	MDM2	p16INK4a	4193	1029	Gene	Gene	p16INK4a|appos|START_ENTITY analysis|nmod|p16INK4a marker|dep|analysis marker|nsubj|END_ENTITY	p16INK4a is a prognostic marker in resected_ductal_pancreatic_cancer : an analysis of p16INK4a , p53 , MDM2 , an Rb .
10329038	0	MDM2	64,68	p21	70,73	MDM2	p21	4193	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	MDM2	93,97	p21	67,70	MDM2	p21	4193	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
10490460	0	MDM2	19,23	p21	48,51	MDM2	p21	17246(Tax:10090)	12575(Tax:10090)	Gene	Gene	protein|nummod|START_ENTITY expression|nmod|protein expression|nmod|expression expression|amod|END_ENTITY	High expression of MDM2 protein and low rate of p21 -LRB- WAF1/CIP1 -RRB- expression in SCID mice Epstein_Barr_virus-induced lymphoproliferation .
19428175	0	MDM2	29,33	p21	55,58	MDM2	p21	4193	1026	Gene	Gene	oncogene|nsubj|START_ENTITY oncogene|dobj|expression expression|amod|END_ENTITY	Gambogic_acid down-regulates MDM2 oncogene and induces p21 -LRB- Waf1/CIP1 -RRB- expression independent of p53 .
14761977	0	MDM2	0,4	p21WAF1/CIP1	32,44	MDM2	p21WAF1/CIP1	4193	1026	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MDM2 is a negative regulator of p21WAF1/CIP1 , independent of p53 .
10329038	0	MDM2	64,68	p27	75,78	MDM2	p27	4193	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10072445	0	MDM2	70,74	p53	24,27	MDM2	p53	4193	7157	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression induction|nmod|inhibition induction|nmod|END_ENTITY	Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression .
10086736	0	MDM2	47,51	p53	19,22	MDM2	p53	4193	7157	Gene	Gene	appear|nsubj|START_ENTITY appear|ccomp|Aberrations Aberrations|nmod|p53 p53|compound|END_ENTITY	Aberrations of the p53 pathway components p53 , MDM2 and CDKN2A appear independent in diffuse large B_cell_lymphoma .
10086736	0	MDM2	47,51	p53	42,45	MDM2	p53	4193	7157	Gene	Gene	appear|nsubj|START_ENTITY appear|ccomp|Aberrations Aberrations|nmod|END_ENTITY	Aberrations of the p53 pathway components p53 , MDM2 and CDKN2A appear independent in diffuse large B_cell_lymphoma .
10208414	0	MDM2	43,47	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	overexpressing|dobj|START_ENTITY cells|acl|overexpressing death|nmod|cells mediated|dobj|death mediated|nsubj|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10208414	0	MDM2	43,47	p53	89,92	MDM2	p53	4193	7157	Gene	Gene	overexpressing|dobj|START_ENTITY overexpressing|nmod|inhibitor inhibitor|nmod|interaction interaction|nmod|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10208414	0	MDM2	67,71	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	interaction|nummod|START_ENTITY inhibitor|nmod|interaction overexpressing|nmod|inhibitor cells|acl|overexpressing death|nmod|cells mediated|dobj|death mediated|nsubj|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10208414	0	MDM2	67,71	p53	89,92	MDM2	p53	4193	7157	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10347217	0	MDM2	71,75	p53	32,35	MDM2	p53	4193	7157	Gene	Gene	ubiquitinated|nmod|START_ENTITY efficiently|dep|ubiquitinated be|advmod|efficiently required|xcomp|be required|nmod|END_ENTITY	Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2 .
10611293	0	MDM2	80,84	p53	37,40	MDM2	p53	4193	7157	Gene	Gene	interaction|nmod|START_ENTITY motif|dep|interaction motif|nmod|END_ENTITY	The alpha-helical FXXPhiPhi motif in p53 : TAF interaction and discrimination by MDM2 .
10611322	0	MDM2	39,43	p53	53,56	MDM2	p53	4193	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY precedes|nsubj|phosphorylation precedes|dobj|accumulation accumulation|compound|END_ENTITY	Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage .
10626788	0	MDM2	41,45	p53	16,19	MDM2	p53	4193	7157	Gene	Gene	down-regulation|compound|START_ENTITY induces|nmod|down-regulation induces|dobj|accumulation accumulation|compound|END_ENTITY	Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation .
10645001	0	MDM2	56,60	p53	21,24	MDM2	p53	4193	7157	Gene	Gene	function|compound|START_ENTITY requires|dobj|function requires|nsubj|exclusion exclusion|nmod|END_ENTITY	Nuclear exclusion of p53 in a subset of tumors requires MDM2 function .
10681559	0	MDM2	38,42	p53	59,62	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	p90|appos|START_ENTITY p90|acl|destabilize destabilize|dobj|END_ENTITY	p76 -LRB- MDM2 -RRB- inhibits the ability of p90 -LRB- MDM2 -RRB- to destabilize p53 .
10681559	0	MDM2	4,8	p53	59,62	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	p76|appos|START_ENTITY inhibits|nsubj|p76 inhibits|dobj|ability ability|nmod|p90 p90|acl|destabilize destabilize|dobj|END_ENTITY	p76 -LRB- MDM2 -RRB- inhibits the ability of p90 -LRB- MDM2 -RRB- to destabilize p53 .
10688649	0	MDM2	84,88	p53	4,7	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY expression|nmod|inhibitor regulate|dobj|expression regulate|nsubj|protein protein|nummod|END_ENTITY	The p53 tumor suppressor protein does not regulate expression of its own inhibitor , MDM2 , except under conditions of stress .
10721693	0	MDM2	0,4	p53	30,33	MDM2	p53	4193	7157	Gene	Gene	START_ENTITY|dep|regulator regulator|nmod|protein protein|compound|END_ENTITY	MDM2 -- master regulator of the p53 tumor suppressor protein .
10830726	0	MDM2	137,141	p53	40,43	MDM2	p53	4193	7157	Gene	Gene	overexpressing|dobj|START_ENTITY mediated|xcomp|overexpressing mediated|nmod|CTS1 CTS1|appos|derivative derivative|compound|END_ENTITY	Cancer gene therapy mediated by CTS1 , a p53 derivative : advantage over wild-type p53 in growth inhibition of human tumors overexpressing MDM2 .
10830726	0	MDM2	137,141	p53	81,84	MDM2	p53	4193	7157	Gene	Gene	overexpressing|dobj|START_ENTITY mediated|xcomp|overexpressing mediated|nmod|CTS1 CTS1|appos|derivative derivative|dep|advantage advantage|nmod|END_ENTITY	Cancer gene therapy mediated by CTS1 , a p53 derivative : advantage over wild-type p53 in growth inhibition of human tumors overexpressing MDM2 .
10835493	0	MDM2	0,4	p53	43,46	MDM2	p53	4193	7157	Gene	Gene	overexpression|nsubj|START_ENTITY overexpression|nmod|alteration alteration|nmod|protein protein|compound|END_ENTITY	MDM2 overexpression with alteration of the p53 protein and gene status in oral carcinogenesis .
10845931	0	MDM2	113,117	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	loop|compound|START_ENTITY stabilization|dep|loop stabilization|compound|END_ENTITY	p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14 -LRB- ARF -RRB- - MDM2 loop in ex vivo and cultured adult_T-cell_leukemia / lymphoma cells .
10914734	0	MDM2	166,170	p53	132,135	MDM2	p53	4193	7157	Gene	Gene	down-regulation|compound|START_ENTITY accumulation|nmod|down-regulation accumulation|compound|END_ENTITY	Induction of apoptosis in human esophageal_cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes : involvement of p53 accumulation via ARF-mediated MDM2 down-regulation .
10914734	0	MDM2	166,170	p53	96,99	MDM2	p53	4193	7157	Gene	Gene	down-regulation|compound|START_ENTITY accumulation|nmod|down-regulation involvement|nmod|accumulation Induction|dep|involvement Induction|nmod|apoptosis apoptosis|nmod|cells cells|nmod|transfer transfer|nmod|END_ENTITY	Induction of apoptosis in human esophageal_cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes : involvement of p53 accumulation via ARF-mediated MDM2 down-regulation .
10949923	0	MDM2	19,23	p53	12,15	MDM2	p53	4193	7157	Gene	Gene	Switch|nmod|START_ENTITY Switch|nmod|END_ENTITY	Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size .
10963376	0	MDM2	18,22	p53	85,88	MDM2	p53	4193	7157	Gene	Gene	protein|nummod|START_ENTITY Overexpression|nmod|protein Overexpression|dep|relationship relationship|nmod|overexpression overexpression|compound|END_ENTITY	Overexpression of MDM2 protein in intrahepatic_cholangiocarcinoma : relationship with p53 overexpression , Ki-67 labeling , and clinicopathological features .
10980696	0	MDM2	4,8	p53	51,54	MDM2	p53	4193	7157	Gene	Gene	domain|compound|START_ENTITY required|nsubjpass|domain required|xcomp|promote promote|dobj|export export|nummod|END_ENTITY	The MDM2 RING-finger domain is required to promote p53 nuclear export .
11012984	0	MDM2	60,64	p53	106,109	MDM2	p53	4193	7157	Gene	Gene	overexpression|compound|START_ENTITY concomitant|nmod|overexpression inactivation|nmod|concomitant correlates|nsubj|inactivation correlates|nmod|overexpression overexpression|compound|END_ENTITY	Immunohistochemical inactivation of p14ARF concomitant with MDM2 overexpression inversely correlates with p53 overexpression in oral_squamous_cell_carcinoma .
11070080	0	MDM2	0,4	p53	28,31	MDM2	p53	4193	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|acetylation acetylation|compound|END_ENTITY	MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins .
11091516	0	MDM2	27,31	p53	81,84	MDM2	p53	4193	7157	Gene	Gene	Gene|compound|START_ENTITY Amplification|nmod|Gene Amplification|nmod|Breast_Cancers Breast_Cancers|nmod|Alterations Alterations|compound|END_ENTITY	Low Grade Amplification of MDM2 Gene in a Subset of Human Breast_Cancers without p53 Alterations .
11125034	0	MDM2	0,4	p53	35,38	MDM2	p53	4193	7157	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|attenuates attenuates|nsubj|exclusion exclusion|nmod|END_ENTITY	MDM2 mediated nuclear exclusion of p53 attenuates etoposide-induced apoptosis in neuroblastoma cells .
11152666	0	MDM2	21,25	p53	48,51	MDM2	p53	4193	7157	Gene	Gene	Stabilization|nmod|START_ENTITY oncoprotein|nsubj|Stabilization oncoprotein|nmod|END_ENTITY	Stabilization of the MDM2 oncoprotein by mutant p53 .
11223035	0	MDM2	18,22	p53	34,37	MDM2	p53	4193	7157	Gene	Gene	Downregulation|nmod|START_ENTITY stabilizes|nsubj|Downregulation stabilizes|dobj|END_ENTITY	Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents .
11223035	0	MDM2	18,22	p53	52,55	MDM2	p53	4193	7157	Gene	Gene	Downregulation|nmod|START_ENTITY stabilizes|nsubj|Downregulation stabilizes|advcl|inhibiting inhibiting|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents .
11245471	0	MDM2	62,66	p53	44,47	MDM2	p53	4193	7157	Gene	Gene	level|nmod|START_ENTITY level|nsubj|role role|nmod|p73 p73|nmod|modulation modulation|nmod|END_ENTITY	A possible role of p73 on the modulation of p53 level through MDM2 .
11313871	0	MDM2	41,45	p53	49,52	MDM2	p53	4193	7157	Gene	Gene	domain|nmod|START_ENTITY contribution|nmod|domain contribution|nmod|stability stability|compound|END_ENTITY	The contribution of the acidic domain of MDM2 to p53 and MDM2 stability .
11331246	0	MDM2	52,56	p53	11,14	MDM2	p53	4193	7157	Gene	Gene	Control|nmod|START_ENTITY Control|nmod|ubiquitination ubiquitination|compound|END_ENTITY	Control of p53 ubiquitination and nuclear export by MDM2 and ARF .
11331871	0	MDM2	53,57	p53	17,20	MDM2	p53	4193	7157	Gene	Gene	relocation|nmod|START_ENTITY p14ARF|nmod|relocation Stabilization|nmod|p14ARF Stabilization|nmod|END_ENTITY	Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus .
11423970	0	MDM2	57,61	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	expression|compound|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of p53 by roscovitine-mediated suppression of MDM2 expression .
11485818	0	MDM2	0,4	p53	19,22	MDM2	p53	4193	7157	Gene	Gene	START_ENTITY|dep|life life|nmod|END_ENTITY	MDM2 : life without p53 .
11505267	0	MDM2	0,4	p53	12,15	MDM2	p53	4193	7157	Gene	Gene	+|compound|START_ENTITY +|dep|CDK4 CDK4|dep|oral_liposarcoma oral_liposarcoma|compound|END_ENTITY	MDM2 + / CDK4 + / p53 + oral_liposarcoma : case report and review of the literature .
11507088	0	MDM2	14,18	p53	50,53	MDM2	p53	4193	7157	Gene	Gene	Inhibition|nmod|START_ENTITY contributes|nsubj|Inhibition contributes|nmod|stabilization stabilization|compound|END_ENTITY	Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization .
11528400	0	MDM2	104,108	p53	121,124	MDM2	p53	17246(Tax:10090)	22059(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|acl|regulate regulate|dobj|END_ENTITY	Rescue of embryonic_lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 .
11559539	0	MDM2	72,76	p53	28,31	MDM2	p53	4193	7157	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|distribution distribution|nmod|END_ENTITY	Subcellular distribution of p53 and p73 are differentially regulated by MDM2 .
11692147	0	MDM2	15,19	p53	88,91	MDM2	p53	4193	7157	Gene	Gene	expression|nummod|START_ENTITY Alterations|nmod|expression Alterations|dep|relationship relationship|nmod|status status|compound|END_ENTITY	Alterations in MDM2 expression in esophageal_squamous_cell_carcinoma : relationship with p53 status .
11715018	0	MDM2	54,58	p53	18,21	MDM2	p53	4193	7157	Gene	Gene	phosphorylation|compound|START_ENTITY ubiquitination|nmod|phosphorylation ubiquitination|compound|END_ENTITY	HER-2 / neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation .
11753042	0	MDM2	100,104	p53	95,98	MDM2	p53	4193	7157	Gene	Gene	p16INK4a|appos|START_ENTITY p16INK4a|appos|END_ENTITY	p16INK4a is a prognostic marker in resected_ductal_pancreatic_cancer : an analysis of p16INK4a , p53 , MDM2 , an Rb .
11820589	0	MDM2	5,9	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	staining|dep|START_ENTITY staining|compound|END_ENTITY	p53 , MDM2 , bcl-2 staining in follicular_neoplasms of the thyroid gland .
11925449	0	MDM2	94,98	p53	155,158	MDM2	p53	4193	7157	Gene	Gene	site|compound|START_ENTITY site|acl:relcl|increases increases|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo .
11925449	0	MDM2	94,98	p53	73,76	MDM2	p53	4193	7157	Gene	Gene	site|compound|START_ENTITY contains|dobj|site contains|nsubj|region region|nmod|domain domain|nmod|END_ENTITY	The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo .
11953423	0	MDM2	21,25	p53	71,74	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	dependence|nmod|START_ENTITY dependence|nmod|END_ENTITY	Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 .
11971195	0	MDM2	96,100	p53	47,50	MDM2	p53	4193	7157	Gene	Gene	mediated|nmod|START_ENTITY degradation|acl|mediated resistant|nmod|degradation make|xcomp|resistant make|nsubj|mutations mutations|nmod|C-terminus C-terminus|nmod|END_ENTITY	Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human_papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells .
12027449	0	MDM2	134,138	p53	0,3	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	forming|nmod|START_ENTITY occurs|advcl|forming p51B|acl:relcl|occurs p51|dep|p51B p51|nummod|END_ENTITY	p53 gene family p51 -LRB- p63 -RRB- - encoded , secondary transactivator p51B -LRB- TAp63alpha -RRB- occurs without forming an immunoprecipitable complex with MDM2 , but responds to genotoxic stress by accumulation .
12068014	0	MDM2	0,4	p53	74,77	MDM2	p53	4193	7157	Gene	Gene	PCAF|compound|START_ENTITY PCAF|dep|END_ENTITY	MDM2 inhibits PCAF -LRB- p300/CREB-binding protein-associated factor -RRB- - mediated p53 acetylation .
12208736	0	MDM2	94,98	p53	51,54	MDM2	p53	4193	7157	Gene	Gene	disrupting|nmod|START_ENTITY stabilize|advcl|disrupting stabilize|dobj|END_ENTITY	The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 .
12208736	0	MDM2	94,98	p53	87,90	MDM2	p53	4193	7157	Gene	Gene	disrupting|nmod|START_ENTITY disrupting|dobj|regulation regulation|nmod|END_ENTITY	The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 .
12536604	0	MDM2	45,49	p53	36,39	MDM2	p53	4193	7157	Gene	Gene	overexpression|nummod|START_ENTITY END_ENTITY|nmod|overexpression	-LSB- Role of functional inactivation of p53 from MDM2 overexpression in hepatocarcinogenesis -RSB- .
12832479	0	MDM2	29,33	p53	51,54	MDM2	p53	4193	7157	Gene	Gene	domain|compound|START_ENTITY contribution|nmod|domain contribution|nmod|ubiquitination ubiquitination|compound|END_ENTITY	Critical contribution of the MDM2 acidic domain to p53 ubiquitination .
14507915	0	MDM2	0,4	p53	92,95	MDM2	p53	4193	7157	Gene	Gene	antagonize|nsubj|START_ENTITY antagonize|nmod|interaction interaction|nmod|END_ENTITY	MDM2 and promyelocytic_leukemia antagonize each other through their direct interaction with p53 .
14704432	0	MDM2	71,75	p53	26,29	MDM2	p53	4193	7157	Gene	Gene	antagonists|nmod|START_ENTITY pathway|nmod|antagonists pathway|nsubj|activation activation|nmod|END_ENTITY	In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 .
14761977	0	MDM2	0,4	p53	61,64	MDM2	p53	4193	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|p21WAF1/CIP1 p21WAF1/CIP1|appos|independent independent|nmod|END_ENTITY	MDM2 is a negative regulator of p21WAF1/CIP1 , independent of p53 .
15029243	0	MDM2	12,16	p53	80,83	MDM2	p53	4193	7157	Gene	Gene	auto-degradation|compound|START_ENTITY required|nsubjpass|auto-degradation required|nmod|activation activation|compound|END_ENTITY	Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation .
15064742	0	MDM2	31,35	p53	54,57	MDM2	p53	4193	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|pathway pathway|compound|END_ENTITY	A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway .
15094782	0	MDM2	101,105	p53	24,27	MDM2	p53	4193	7157	Gene	Gene	levels|nmod|START_ENTITY due|nmod|levels due|nsubj|accumulation accumulation|nmod|inhibition inhibition|compound|END_ENTITY	Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2 .
15122315	0	MDM2	18,22	p53	43,46	MDM2	p53	4193	7157	Gene	Gene	inhibition|nummod|START_ENTITY inhibition|acl|rescuing rescuing|dobj|activity activity|compound|END_ENTITY	HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function .
15314173	0	MDM2	50,54	p53	32,35	MDM2	p53	4193	7157	Gene	Gene	function|nummod|START_ENTITY inhibiting|dobj|function activates|advcl|inhibiting activates|dobj|END_ENTITY	Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition .
15358376	0	MDM2	29,33	p53	34,37	MDM2	p53	4193	7157	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide .
15358376	0	MDM2	29,33	p53	68,71	MDM2	p53	4193	7157	Gene	Gene	domain|compound|START_ENTITY domain|nmod|fusion fusion|nmod|transactivation transactivation|compound|END_ENTITY	Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide .
15364927	0	MDM2	68,72	p53	23,26	MDM2	p53	4193	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|functions functions|compound|END_ENTITY	Negative regulation of p53 functions by Daxx and the involvement of MDM2 .
15371552	0	MDM2	19,23	p53	42,45	MDM2	p53	4193	7157	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA -LRB- peptide nucleic acid -RRB- conjugates .
15550242	0	MDM2	40,44	p53	69,72	MDM2	p53	4193	7157	Gene	Gene	promoter|compound|START_ENTITY polymorphism|nmod|promoter attenuates|nsubj|polymorphism attenuates|dobj|suppressor suppressor|compound|END_ENTITY	A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans .
15600307	0	MDM2	53,57	p53	22,25	MDM2	p53	4193	7157	Gene	Gene	inhibitor|nmod|START_ENTITY peptide|nmod|inhibitor peptide|nsubj|Use Use|nmod|END_ENTITY	Use of a retroinverso p53 peptide as an inhibitor of MDM2 .
15610030	0	MDM2	111,115	p53	131,134	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	sites|appos|START_ENTITY sites|acl:relcl|regulate regulate|dobj|turnover turnover|compound|END_ENTITY	Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine_double-minute_clone_2_protein -LRB- MDM2 -RRB- that regulate p53 turnover .
15656374	0	MDM2	24,28	p53	19,22	MDM2	p53	314856(Tax:10116)	301300(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY treated|nsubj|gene treated|advcl|-LSB- -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression of p53 , MDM2 and Ref1 gene in cultured retina neurons of SD rats treated with vitamin_B1 and/or elevated pressure -RSB- .
15684615	0	MDM2	51,55	p53	88,91	MDM2	p53	4193	7157	Gene	Gene	destabilization|compound|START_ENTITY loop|dep|destabilization twist|nmod|loop required|nsubjpass|twist required|nmod|activation activation|compound|END_ENTITY	A new twist in the feedback loop : stress-activated MDM2 destabilization is required for p53 activation .
15720184	0	MDM2	0,4	p53	30,33	MDM2	p53	4193	7157	Gene	Gene	node|nsubj|START_ENTITY node|nmod|pathway pathway|compound|END_ENTITY	MDM2 is a central node in the p53 pathway : 12 years and counting .
15753391	0	MDM2	21,25	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	antagonists|nummod|START_ENTITY END_ENTITY|nmod|antagonists	Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors .
16107876	0	MDM2	0,4	p53	62,65	MDM2	p53	4193	7157	Gene	Gene	interaction|nummod|START_ENTITY contributes|nsubj|interaction contributes|nmod|inactivation inactivation|compound|END_ENTITY	MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation .
16202543	0	MDM2	81,85	p53	28,31	MDM2	p53	4193	7157	Gene	Gene	oncogene|compound|START_ENTITY intron|nmod|oncogene down-regulated|nmod|intron down-regulated|nsubj|Characterisation Characterisation|nmod|END_ENTITY	Characterisation of a novel p53 down-regulated promoter in intron 3 of the human MDM2 oncogene .
16443686	0	MDM2	15,19	p53	48,51	MDM2	p53	4193	7157	Gene	Gene	antagonists|compound|START_ENTITY reveal|nsubj|antagonists reveal|dobj|END_ENTITY	Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer : implications for therapy .
16789731	0	MDM2	72,76	p53	78,81	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	murine_double_minute_2|appos|START_ENTITY inhibitor|nmod|murine_double_minute_2 Discovery|nmod|inhibitor Discovery|dep|interaction interaction|compound|END_ENTITY	Discovery of a nanomolar inhibitor of the human murine_double_minute_2 -LRB- MDM2 -RRB- - p53 interaction through an integrated , virtual database screening strategy .
16861890	0	MDM2	104,108	p53	51,54	MDM2	p53	4193	7157	Gene	Gene	complexes|compound|START_ENTITY polyubiquitination|nmod|complexes polyubiquitination|compound|END_ENTITY	L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes .
16905541	0	MDM2	51,55	p53	29,32	MDM2	p53	4193	7157	Gene	Gene	Nutlin|compound|START_ENTITY prevents|nmod|Nutlin prevents|dobj|activation activation|compound|END_ENTITY	MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin .
16925398	0	MDM2	74,78	p53	38,41	MDM2	p53	4193	7157	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubj|analysis analysis|nmod|analogue analogue|compound|END_ENTITY	Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2 .
17002294	0	MDM2	31,35	p53	124,127	MDM2	p53	4193	7157	Gene	Gene	specificity|nmod|START_ENTITY Determinants|nmod|specificity Determinants|dep|disrupts disrupts|dep|motif motif|nmod|END_ENTITY	Determinants of specificity of MDM2 for the activation_domains of p53 and p65 : proline27 disrupts the MDM2-binding motif of p53 .
17002294	0	MDM2	31,35	p53	66,69	MDM2	p53	4193	7157	Gene	Gene	START_ENTITY|nmod|activation_domains activation_domains|nmod|END_ENTITY	Determinants of specificity of MDM2 for the activation_domains of p53 and p65 : proline27 disrupts the MDM2-binding motif of p53 .
17139261	0	MDM2	40,44	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	p53 mediates the negative regulation of MDM2 by orphan receptor TR3 .
17339337	0	MDM2	4,8	p53	60,63	MDM2	p53	4193	7157	Gene	Gene	signal|compound|START_ENTITY signal|nmod|domain domain|nmod|END_ENTITY	The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members .
17363365	0	MDM2	0,4	p53	48,51	MDM2	p53	4193	7157	Gene	Gene	binding|compound|START_ENTITY induces|nsubj|binding induces|nmod|END_ENTITY	MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation .
17363597	0	MDM2	40,44	p53	78,81	MDM2	p53	4193	7157	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene disrupts|nsubj|polymorphism disrupts|dobj|oscillation oscillation|nmod|levels levels|compound|END_ENTITY	A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells .
17369817	0	MDM2	34,38	p53	74,77	MDM2	p53	4193	7157	Gene	Gene	dissociation|compound|START_ENTITY dissociation|nmod|END_ENTITY	C-terminal modifications regulate MDM2 dissociation and nuclear export of p53 .
17499002	0	MDM2	0,4	p53	15,18	MDM2	p53	4193	7157	Gene	Gene	START_ENTITY|dep|regulators regulators|compound|END_ENTITY	MDM2 and MDM4 : p53 regulators as targets in anticancer therapy .
17848574	0	MDM2	0,4	p53	20,23	MDM2	p53	4193	7157	Gene	Gene	chaperones|nsubj|START_ENTITY chaperones|dobj|suppressor suppressor|compound|END_ENTITY	MDM2 chaperones the p53 tumor suppressor .
17875722	0	MDM2	80,84	p53	10,13	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY disruption|nmod|binding Efficient|nmod|disruption Efficient|dobj|activation activation|compound|END_ENTITY	Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX .
17971485	0	MDM2	107,111	p53	56,59	MDM2	p53	4193	7157	Gene	Gene	inhibitors|nummod|START_ENTITY identifies|nmod|inhibitors identifies|dobj|status status|compound|END_ENTITY	Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic_lymphocytic_leukemia .
18256546	0	MDM2	29,33	p53	120,123	MDM2	p53	4193	7157	Gene	Gene	surface|nmod|START_ENTITY modulates|nsubj|surface modulates|nmod|peptides peptides|compound|END_ENTITY	The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides .
18273046	0	MDM2	0,4	p53	121,124	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	inducer|nsubj|START_ENTITY inducer|nmod|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute_lymphoblastic_leukemia cells with wild-type p53 and overexpression of MDM2 .
18273046	0	MDM2	147,151	p53	121,124	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	inducer|nmod|START_ENTITY inducer|nmod|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute_lymphoblastic_leukemia cells with wild-type p53 and overexpression of MDM2 .
18316739	0	MDM2	41,45	p53	23,26	MDM2	p53	4193	7157	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition .
18414049	0	MDM2	137,141	p53	108,111	MDM2	p53	4193	7157	Gene	Gene	apoptosis|nummod|START_ENTITY uncovers|nmod|apoptosis uncovers|dobj|role role|nmod|status status|compound|END_ENTITY	The pre-clinical development of MDM2 inhibitors in chronic_lymphocytic_leukemia uncovers a central role for p53 status in sensitivity to MDM2 inhibitor-mediated apoptosis .
18414049	0	MDM2	32,36	p53	108,111	MDM2	p53	4193	7157	Gene	Gene	inhibitors|nummod|START_ENTITY development|nmod|inhibitors uncovers|nsubj|development uncovers|dobj|role role|nmod|status status|compound|END_ENTITY	The pre-clinical development of MDM2 inhibitors in chronic_lymphocytic_leukemia uncovers a central role for p53 status in sensitivity to MDM2 inhibitor-mediated apoptosis .
18566224	0	MDM2	34,38	p53	16,19	MDM2	p53	4193	7157	Gene	Gene	antagonist|compound|START_ENTITY END_ENTITY|nmod|antagonist	Reactivation of p53 by a specific MDM2 antagonist -LRB- MI-43 -RRB- leads to p21-mediated cell cycle arrest and selective cell death in colon_cancer .
18607552	0	MDM2	0,4	p53	28,31	MDM2	p53	4193	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	MDM2 mRNA expression in the p53 pathway may predict the potential of invasion and liver metastasis in colorectal_cancer .
18638452	0	MDM2	35,39	p53	82,85	MDM2	p53	4193	7157	Gene	Gene	indispensable|nmod|START_ENTITY indispensable|xcomp|regulate regulate|dobj|acetylation acetylation|nmod|END_ENTITY	Acidic domain is indispensable for MDM2 to negatively regulate the acetylation of p53 .
18826207	0	MDM2	44,48	p53	109,112	MDM2	p53	4193	7157	Gene	Gene	transitions|nmod|START_ENTITY Targeting|dobj|transitions Targeting|nmod|dissimilarities dissimilarities|nmod|recognition recognition|compound|END_ENTITY	Targeting the conformational transitions of MDM2 and MDMX : insights into dissimilarities and similarities of p53 recognition .
19098711	0	MDM2	34,38	p53	16,19	MDM2	p53	4193	7157	Gene	Gene	modulating|dobj|START_ENTITY stabilizes|advcl|modulating stabilizes|dobj|END_ENTITY	RYBP stabilizes p53 by modulating MDM2 .
19166840	0	MDM2	73,77	p53	33,36	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY induces|dobj|degradation induces|nsubj|FKBP25 FKBP25|appos|regulator regulator|nmod|pathway pathway|compound|END_ENTITY	FKBP25 , a novel regulator of the p53 pathway , induces the degradation of MDM2 and activation of p53 .
19166840	0	MDM2	73,77	p53	96,99	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	FKBP25 , a novel regulator of the p53 pathway , induces the degradation of MDM2 and activation of p53 .
19255450	0	MDM2	79,83	p53	57,60	MDM2	p53	4193	7157	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|inhibition inhibition|nmod|interactions interactions|compound|END_ENTITY	Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX .
19286999	0	MDM2	56,60	p53	21,24	MDM2	p53	4193	7157	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner .
19321440	0	MDM2	0,4	p53	24,27	MDM2	p53	4193	7157	Gene	Gene	acts|nummod|START_ENTITY acts|nmod|END_ENTITY	MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation .
19369353	0	MDM2	85,89	p53	108,111	MDM2	p53	4193	7157	Gene	Gene	sarcoma-associated_herpesvirus|dobj|START_ENTITY sarcoma-associated_herpesvirus|xcomp|deregulate deregulate|dobj|suppressor suppressor|compound|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway .
19375142	0	MDM2	102,106	p53	71,74	MDM2	p53	4193	7157	Gene	Gene	independent|nmod|START_ENTITY independent|compound|END_ENTITY	Expression of Epstein-Barr_virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2 , leading to repression of p53-mediated transcription .
19421231	0	MDM2	21,25	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	antagonists|nummod|START_ENTITY END_ENTITY|nmod|antagonists	Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr_virus -LRB- EBV -RRB- - positive and EBV-negative Burkitt 's _ lymphoma cells .
19428175	0	MDM2	29,33	p53	96,99	MDM2	p53	4193	7157	Gene	Gene	oncogene|nsubj|START_ENTITY oncogene|dobj|expression expression|amod|independent independent|nmod|END_ENTITY	Gambogic_acid down-regulates MDM2 oncogene and induces p21 -LRB- Waf1/CIP1 -RRB- expression independent of p53 .
19507240	0	MDM2	44,48	p53	96,99	MDM2	p53	4193	7157	Gene	Gene	transitions|nmod|START_ENTITY Targeting|dobj|transitions insights|dep|Targeting insights|nmod|residues residues|acl|affecting affecting|dobj|recognition recognition|compound|END_ENTITY	Targeting the conformational transitions of MDM2 and MDMX : insights into key residues affecting p53 recognition .
19513075	0	MDM2	54,58	p53	119,122	MDM2	p53	4193	7157	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene association|nmod|polymorphism dependent|nsubj|association dependent|nmod|status status|compound|END_ENTITY	The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models .
19565011	0	MDM2	27,31	p53	99,102	MDM2	p53	4193	7157	Gene	Gene	protein|nummod|START_ENTITY inhibition|nmod|protein dependent|nsubj|inhibition dependent|nmod|levels levels|compound|END_ENTITY	Progesterone inhibition of MDM2 p90 protein in MCF-7 human breast_cancer cell line is dependent on p53 levels .
19710698	0	MDM2	49,53	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	antagonist|nmod|START_ENTITY Activation|appos|antagonist Activation|nmod|END_ENTITY	Activation of p53 by Nutlin-3a , an antagonist of MDM2 , induces apoptosis and cellular senescence in adult_T-cell_leukemia cells .
19713735	0	MDM2	18,22	p53	52,55	MDM2	p53	4193	7157	Gene	Gene	peptide|compound|START_ENTITY Design|nmod|peptide based|nsubj|Design based|nmod|family family|compound|END_ENTITY	Design of a novel MDM2 binding peptide based on the p53 family .
19759023	0	MDM2	43,47	p53	59,62	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	control|nummod|START_ENTITY control|nmod|stability stability|compound|END_ENTITY	CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability .
19816404	0	MDM2	32,36	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	oligomerization|amod|START_ENTITY regulating|dobj|oligomerization activates|advcl|regulating activates|dobj|END_ENTITY	ATM activates p53 by regulating MDM2 oligomerization and E3 processivity .
19842060	0	MDM2	91,95	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	transcription|nmod|START_ENTITY Promotes|nmod|transcription Promotes|nsubj|END_ENTITY	p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2 .
19903807	0	MDM2	36,40	p53	113,116	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY antagonist|nsubj|activity antagonist|nmod|END_ENTITY	Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53 .
19910468	0	MDM2	88,92	p53	79,82	MDM2	p53	4193	7157	Gene	Gene	inhibiting|nmod|START_ENTITY inhibiting|dobj|interaction interaction|nmod|END_ENTITY	Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX .
19941079	0	MDM2	16,20	p53	147,150	MDM2	p53	4193	7157	Gene	Gene	SNP309|compound|START_ENTITY Associations|nmod|SNP309 stage|nsubj|Associations stage|xcomp|patients patients|nmod|tumors tumors|compound|END_ENTITY	Associations of MDM2 SNP309 , transcriptional activity , mRNA expression , and survival in stage I non-small-cell lung_cancer patients with wild-type p53 tumors .
19945467	0	MDM2	76,80	p53	18,21	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2 .
19958516	0	MDM2	29,33	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of p53 binding to MDM2 : computational studies reveal important roles of Tyr100 .
19958544	0	MDM2	3,7	p53	37,40	MDM2	p53	4193	7157	Gene	Gene	antagonist|compound|START_ENTITY restores|nsubj|antagonist restores|dobj|functions functions|compound|END_ENTITY	An MDM2 antagonist -LRB- MI-319 -RRB- restores p53 functions and increases the life span of orally treated follicular_lymphoma bearing animals .
20019189	0	MDM2	29,33	p53	45,48	MDM2	p53	4193	7157	Gene	Gene	regulation|nmod|START_ENTITY influences|nsubj|regulation influences|dobj|activity activity|compound|END_ENTITY	Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis .
20156675	0	MDM2	0,4	p53	115,118	MDM2	p53	4193	7157	Gene	Gene	MI-319|compound|START_ENTITY treatment|nsubj|MI-319 treatment|nmod|pancreatic_cancer pancreatic_cancer|nmod|function function|compound|END_ENTITY	MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic_cancer independent of p53 function .
20157557	0	MDM2	87,91	p53	40,43	MDM2	p53	4193	7157	Gene	Gene	nutlin-3|compound|START_ENTITY revealed|nmod|nutlin-3 revealed|nsubj|activity activity|nmod|pathway pathway|compound|END_ENTITY	Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3 .
20190571	0	MDM2	42,46	p53	24,27	MDM2	p53	4193	7157	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Differential binding of p53 and nutlin to MDM2 and MDMX : computational studies .
20333547	0	MDM2	18,22	p53	73,76	MDM2	p53	4193	7157	Gene	Gene	Interplay|nmod|START_ENTITY Interplay|dep|regulators regulators|nmod|END_ENTITY	Interplay between MDM2 , MDMX , Pirh2 and COP1 : the negative regulators of p53 .
20372076	0	MDM2	20,24	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	loops|compound|START_ENTITY inactivation|nmod|loops inactivation|compound|END_ENTITY	p53 inactivation by MDM2 and MDMX negative feedback loops in testicular_germ_cell_tumors .
20406950	0	MDM2	60,64	p53	139,142	MDM2	p53	4193	7157	Gene	Gene	antagonist|compound|START_ENTITY activity|nmod|antagonist nutlin-3a|nsubj|activity nutlin-3a|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	1,25-dihydroxyvitamin _ D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute_myeloid_leukemia cells expressing wild-type p53 .
20484049	0	MDM2	107,111	p53	62,65	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	stabilizing|dobj|START_ENTITY promotes|advcl|stabilizing promotes|dobj|degradation degradation|compound|END_ENTITY	Smad ubiquitylation regulatory factor 1/2 -LRB- Smurf1/2 -RRB- promotes p53 degradation by stabilizing the E3 ligase MDM2 .
20588255	0	MDM2	0,4	p53	56,59	MDM2	p53	4193	7157	Gene	Gene	recruitment|compound|START_ENTITY regulates|nsubj|recruitment regulates|dobj|output output|nummod|END_ENTITY	MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output .
20588277	0	MDM2	42,46	p53	135,138	MDM2	p53	4193	7157	Gene	Gene	inhibitor|nmod|START_ENTITY Nutlin-3|appos|inhibitor promotes|nsubj|Nutlin-3 promotes|dobj|cells cells|acl|harbouring harbouring|dobj|END_ENTITY	Nutlin-3 , the small-molecule inhibitor of MDM2 , promotes senescence and radiosensitises laryngeal_carcinoma cells harbouring wild-type p53 .
20639885	0	MDM2	53,57	p53	18,21	MDM2	p53	4193	7157	Gene	Gene	domain|nmod|START_ENTITY binds|dobj|domain binds|nsubj|terminus terminus|nmod|END_ENTITY	The C terminus of p53 binds the N-terminal domain of MDM2 .
20680659	0	MDM2	129,133	p53	86,89	MDM2	p53	4193	7157	Gene	Gene	expression|compound|START_ENTITY hyperacetylation|nmod|expression hyperacetylation|compound|END_ENTITY	Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression .
20847049	0	MDM2	44,48	p53	8,11	MDM2	p53	4193	7157	Gene	Gene	signal|compound|START_ENTITY site|nmod|signal site|compound|END_ENTITY	A novel p53 phosphorylation site within the MDM2 ubiquitination signal : II .
20851891	0	MDM2	44,48	p53	138,141	MDM2	p53	4193	7157	Gene	Gene	signal|compound|START_ENTITY site|nmod|signal linked|nsubjpass|site linked|nmod|inactivation inactivation|nmod|function function|compound|END_ENTITY	A novel p53 phosphorylation site within the MDM2 ubiquitination signal : I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function .
20851891	0	MDM2	44,48	p53	8,11	MDM2	p53	4193	7157	Gene	Gene	signal|compound|START_ENTITY site|nmod|signal site|compound|END_ENTITY	A novel p53 phosphorylation site within the MDM2 ubiquitination signal : I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function .
21060154	0	MDM2	40,44	p53	28,31	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice .
21191186	0	MDM2	43,47	p53	57,60	MDM2	p53	4193	7157	Gene	Gene	lid|nmod|START_ENTITY states|nmod|lid regulate|nsubj|states regulate|dobj|END_ENTITY	Chemical states of the N-terminal `` lid '' of MDM2 regulate p53 binding : simulations reveal complexities of modulation .
21261729	0	MDM2	0,4	p53	93,96	MDM2	p53	4193	7157	Gene	Gene	antagonist|compound|START_ENTITY inhibit|nsubj|antagonist inhibit|nmod|types types|nmod|END_ENTITY	MDM2 antagonist can inhibit tumor growth in hepatocellular_carcinoma with different types of p53 in vitro .
21295542	0	MDM2	48,52	p53	88,91	MDM2	p53	4193	7157	Gene	Gene	transactivation|nmod|START_ENTITY represses|dobj|transactivation represses|nmod|formation formation|nmod|END_ENTITY	CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose_deprivation .
21314128	0	MDM2	56,60	p53	62,65	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	murine_double_minute_2|appos|START_ENTITY inhibitors|nmod|murine_double_minute_2 inhibitors|dep|interaction interaction|compound|END_ENTITY	Isoindolinone inhibitors of the murine_double_minute_2 -LRB- MDM2 -RRB- - p53 protein-protein interaction : structure-activity studies leading to improved potency .
21391906	0	MDM2	50,54	p53	28,31	MDM2	p53	4193	7157	Gene	Gene	antagonists|compound|START_ENTITY activation|nmod|antagonists activation|nmod|END_ENTITY	Pharmacologic activation of p53 by small-molecule MDM2 antagonists .
21454483	0	MDM2	46,50	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	domain|compound|START_ENTITY function|nmod|domain function|nsubj|Inhibition Inhibition|nmod|binding binding|compound|END_ENTITY	Inhibition of p53 DNA binding function by the MDM2 protein acidic domain .
21460101	0	MDM2	87,91	p53	27,30	MDM2	p53	4193	7157	Gene	Gene	using|dobj|START_ENTITY cells|acl|using pathway|nmod|cells pathway|compound|END_ENTITY	Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3 .
21478269	0	MDM2	38,42	p53	101,104	MDM2	p53	4193	7157	Gene	Gene	inactivation|nmod|START_ENTITY causes|nsubj|inactivation causes|dobj|stabilization stabilization|nmod|END_ENTITY	Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells .
21685937	0	MDM2	82,86	p53	57,60	MDM2	p53	4193	7157	Gene	Gene	phosphorylation|compound|START_ENTITY inactivating|nmod|phosphorylation inactivating|dobj|END_ENTITY	SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival .
21785463	0	MDM2	64,68	p53	33,36	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	enhancing|dobj|START_ENTITY regulates|advcl|enhancing regulates|dobj|stabilization stabilization|compound|END_ENTITY	JAK2 -LRB- V617F -RRB- negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative_neoplasms .
21900752	0	MDM2	0,4	p53	39,42	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|SUMO-2 SUMO-2|dep|modification modification|nmod|END_ENTITY	MDM2 promotes SUMO-2 / 3 modification of p53 to modulate transcriptional activity .
22134502	0	MDM2	0,4	p53	56,59	MDM2	p53	4193	7157	Gene	Gene	SNP309|compound|START_ENTITY modifies|nsubj|SNP309 modifies|dobj|significance significance|nmod|status status|compound|END_ENTITY	MDM2 SNP309 modifies the prognostic significance of the p53 mutational status in patients with ovarian_cancer .
22208493	0	MDM2	0,4	p53	79,82	MDM2	p53	4193	7157	Gene	Gene	amplification|nummod|START_ENTITY correlates|nsubj|amplification correlates|nmod|expression expression|compound|END_ENTITY	MDM2 amplification in malignant_peripheral_nerve_sheath_tumors correlates with p53 protein expression .
22348305	0	MDM2	76,80	p53	30,33	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	p19|nmod|START_ENTITY inhibited|nmod|p19 inhibited|nsubjpass|suppression suppression|nmod|END_ENTITY	Bach1-mediated suppression of p53 is inhibited by p19 -LRB- ARF -RRB- independently of MDM2 .
22377766	0	MDM2	0,4	p53	96,99	MDM2	p53	4193	7157	Gene	Gene	nutlin-3a|compound|START_ENTITY induces|nsubj|nutlin-3a induces|parataxis|role role|nmod|END_ENTITY	MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous_T-cell_lymphoma : role of p53 .
22411991	0	MDM2	81,85	p53	43,46	MDM2	p53	4193	7157	Gene	Gene	sumoylation|compound|START_ENTITY regulation|nmod|sumoylation leads|nmod|regulation leads|nmod|degradation degradation|compound|END_ENTITY	Overexpression of SKI_oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation .
22444248	0	MDM2	136,140	p53	41,44	MDM2	p53	4193	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY role|nmod|phosphorylation reexamined|nsubj|role using|parataxis|reexamined using|nsubj|Interrogation Interrogation|nmod|phosphorylation phosphorylation|nmod|activation activation|compound|END_ENTITY	Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation : the functional role of Ser17 phosphorylation in MDM2 reexamined .
22444248	0	MDM2	17,21	p53	41,44	MDM2	p53	4193	7157	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|activation activation|compound|END_ENTITY	Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation : the functional role of Ser17 phosphorylation in MDM2 reexamined .
22525275	0	MDM2	52,56	p53	22,25	MDM2	p53	4193	7157	Gene	Gene	auto-ubiquitination|nummod|START_ENTITY inhibiting|dobj|auto-ubiquitination promotes|advcl|inhibiting promotes|dobj|degradation degradation|compound|END_ENTITY	Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic_syndrome with chromosome 5q deletion .
22578852	0	MDM2	42,46	p53	114,117	MDM2	p53	4193	7157	Gene	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|lines lines|nmod|mutation mutation|compound|END_ENTITY	Comparison of the antitumor effects of an MDM2 inhibitor , nutlin-3 , in feline lymphoma cell lines with or without p53 mutation .
22703554	0	MDM2	177,181	p53	131,134	MDM2	p53	4193	7157	Gene	Gene	expression|compound|START_ENTITY displaying|nmod|expression displaying|dobj|pattern pattern|nmod|concomitant concomitant|compound|END_ENTITY	Hypermethylation of the 5 ' CpG island of the p14ARF flanking exon 1b in human colorectal_cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression .
22745160	0	MDM2	56,60	p53	18,21	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization .
22807444	0	MDM2	76,80	p53	122,125	MDM2	p53	4193	7157	Gene	Gene	protein|compound|START_ENTITY subdomains|nmod|protein binding|nmod|subdomains binding|dep|implications implications|acl|regulating regulating|dobj|interaction interaction|compound|END_ENTITY	Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein : implications for regulating the p53 MDM2/MDMX interaction .
22807444	0	MDM2	76,80	p53	36,39	MDM2	p53	4193	7157	Gene	Gene	protein|compound|START_ENTITY subdomains|nmod|protein subdomains|compound|END_ENTITY	Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein : implications for regulating the p53 MDM2/MDMX interaction .
23032264	0	MDM2	46,50	p53	62,65	MDM2	p53	4193	7157	Gene	Gene	activation|nmod|START_ENTITY represses|dobj|activation represses|xcomp|prevent prevent|dobj|degradation degradation|compound|END_ENTITY	cIAP2 represses IKKa/b-mediated activation of MDM2 to prevent p53 degradation .
23150753	0	MDM2	68,72	p53	27,30	MDM2	p53	4193	7157	Gene	Gene	Mediated|nmod|START_ENTITY Mediated|nsubjpass|Regulation Regulation|nmod|Responses Responses|compound|END_ENTITY	The Regulation of Multiple p53 Stress Responses is Mediated through MDM2 .
23150757	0	MDM2	115,119	p53	134,137	MDM2	p53	4193	7157	Gene	Gene	Repression|compound|START_ENTITY Repression|nmod|Activity Activity|compound|END_ENTITY	Dual Roles of MDM2 in the Regulation of p53 : Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity .
23150757	0	MDM2	14,18	p53	40,43	MDM2	p53	4193	7157	Gene	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|END_ENTITY	Dual Roles of MDM2 in the Regulation of p53 : Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity .
23150760	0	MDM2	13,17	p53	66,69	MDM2	p53	4193	7157	Gene	Gene	Phosphorylation|compound|START_ENTITY Roles|nmod|Phosphorylation Roles|nmod|Signaling Signaling|nmod|END_ENTITY	The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53 .
23201157	0	MDM2	79,83	p53	45,48	MDM2	p53	4193	7157	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2 .
23324352	0	MDM2	67,71	p53	35,38	MDM2	p53	4193	7157	Gene	Gene	proteins|compound|START_ENTITY peptide|nmod|proteins peptide|nsubj|mechanisms mechanisms|nmod|END_ENTITY	On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins : a Brownian dynamics study .
23398638	0	MDM2	81,85	p53	21,24	MDM2	p53	4193	7157	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|access access|nmod|END_ENTITY	Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2 .
23400593	0	MDM2	0,4	p53	48,51	MDM2	p53	4193	7157	Gene	Gene	RG7112|nummod|START_ENTITY activates|nsubj|RG7112 activates|dobj|END_ENTITY	MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models .
23623661	0	MDM2	61,65	p53	10,13	MDM2	p53	4193	7157	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin_B1 / CDK1-phosphorylated nuclear iASPP .
23652204	0	MDM2	52,56	p53	102,105	MDM2	p53	4193	7157	Gene	Gene	apoptosis|compound|START_ENTITY ligases|dobj|apoptosis ligases|nmod|END_ENTITY	A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53 .
23826318	0	MDM2	0,4	p53	27,30	MDM2	p53	4193	7157	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Independently Independently|compound|END_ENTITY	MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity .
23839035	0	MDM2	66,70	p53	43,46	MDM2	p53	4193	7157	Gene	Gene	binds|nummod|START_ENTITY mechanism|dep|binds mechanism|nmod|crosstalk crosstalk|nmod|pathways pathways|compound|END_ENTITY	A novel mechanism of crosstalk between the p53 and NFkB pathways : MDM2 binds and inhibits p65RelA .
23977270	0	MDM2	59,63	p53	31,34	MDM2	p53	4193	7157	Gene	Gene	inhibitor|compound|START_ENTITY reactivation|nmod|inhibitor reactivation|compound|END_ENTITY	Human glioblastoma_multiforme : p53 reactivation by a novel MDM2 inhibitor .
24240203	0	MDM2	28,32	p53	72,75	MDM2	p53	4193	7157	Gene	Gene	overexpression|compound|START_ENTITY reactivates|nsubj|overexpression reactivates|dobj|END_ENTITY	Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood_leukemia .
24264557	0	MDM2	70,74	p53	86,89	MDM2	p53	4193	7157	Gene	Gene	modes|nmod|START_ENTITY analysis|nmod|modes induced|nsubj|analysis induced|nmod|bindings bindings|compound|END_ENTITY	A computational analysis of binding modes and conformation changes of MDM2 induced by p53 and inhibitor bindings .
24309210	0	MDM2	25,29	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	RG7112|compound|START_ENTITY END_ENTITY|nmod|RG7112	Activation of p53 by the MDM2 inhibitor RG7112 impairs thrombopoiesis .
24356649	0	MDM2	8,12	p53	37,40	MDM2	p53	4193	7157	Gene	Gene	isoforms|nsubj|START_ENTITY isoforms|xcomp|promote promote|dobj|accumulation accumulation|compound|END_ENTITY	Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis .
24418072	0	MDM2	101,105	p53	72,75	MDM2	p53	4193	7157	Gene	Gene	bound|nmod|START_ENTITY bound|csubj|Probing Probing|dobj|origin origin|nmod|stability stability|nmod|analogs analogs|compound|END_ENTITY	Probing the origin of structural stability of single and double stapled p53 peptide analogs bound to MDM2 .
24584189	0	MDM2	61,65	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	terminal|dep|START_ENTITY END_ENTITY|nmod|terminal	p53 N - terminal binding and stabilisation by PIAS3 inhibits MDM2 - induced p53 ubiquitination and regulates cell growth .
24584189	0	MDM2	61,65	p53	76,79	MDM2	p53	4193	7157	Gene	Gene	terminal|dep|START_ENTITY p53|nmod|terminal induced|dep|p53 induced|dobj|ubiquitination ubiquitination|compound|END_ENTITY	p53 N - terminal binding and stabilisation by PIAS3 inhibits MDM2 - induced p53 ubiquitination and regulates cell growth .
24882579	0	MDM2	67,71	p53	25,28	MDM2	p53	4193	7157	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|dobj|pathway pathway|compound|END_ENTITY	miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2 .
25172547	0	MDM2	77,81	p53	51,54	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY downregulates|nmod|activation downregulates|dobj|expression expression|nmod|END_ENTITY	Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B .
25181509	0	MDM2	18,22	p53	89,92	MDM2	p53	4193	7157	Gene	Gene	Ligase|compound|START_ENTITY Inhibition|nmod|Ligase induces|nsubj|Inhibition induces|nmod|models models|compound|END_ENTITY	Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple_myeloma , and acts synergistically with ABT-737 .
25263199	0	MDM2	42,46	p53	23,26	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY due|nmod|loss END_ENTITY|amod|due	Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens_dysmorphogenesis .
25275651	0	MDM2	39,43	p53	44,47	MDM2	p53	4193	7157	Gene	Gene	Inhibition|nmod|START_ENTITY Basis|nmod|Inhibition Basis|dep|Interaction Interaction|compound|END_ENTITY	Structural Basis for Inhibition of the MDM2 : p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display .
25543083	0	MDM2	49,53	p53	89,92	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	Lid|nmod|START_ENTITY Mutation|nmod|Lid Enhances|nsubj|Mutation Enhances|dobj|Polyubiquitination Polyubiquitination|nmod|END_ENTITY	Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis .
25584963	0	MDM2	95,99	p53	51,54	MDM2	p53	4193	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nsubj|characterization characterization|nmod|effect effect|nmod|END_ENTITY	A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2 .
25591003	0	MDM2	77,81	p53	39,42	MDM2	p53	4193	7157	Gene	Gene	recognition|compound|START_ENTITY domains|nmod|recognition domains|nsubj|convergence convergence|nmod|transactivation transactivation|compound|END_ENTITY	Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition .
25840370	0	MDM2	76,80	p53	61,64	MDM2	p53	4193	7157	Gene	Gene	peptide|nmod|START_ENTITY peptide|compound|END_ENTITY	The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans .
25902914	0	MDM2	57,61	p53	122,125	MDM2	p53	4193	7157	Gene	Gene	transcription|nummod|START_ENTITY regulation|nmod|transcription promotes|dobj|regulation promotes|xcomp|stabilize stabilize|dobj|END_ENTITY	Oroxylin_A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells .
26220995	0	MDM2	19,23	p53	76,79	MDM2	p53	4193	7157	Gene	Gene	Structure|nmod|START_ENTITY reveals|nsubj|Structure reveals|dobj|basis basis|nmod|activation activation|compound|END_ENTITY	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
26220995	0	MDM2	19,23	p53	76,79	MDM2	p53	4193	7157	Gene	Gene	Structure|nmod|START_ENTITY reveals|nsubj|Structure reveals|dobj|basis basis|nmod|activation activation|compound|END_ENTITY	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
26350565	0	MDM2	109,113	p53	59,62	MDM2	p53	4193	7157	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast_cancer cells .
26428461	0	MDM2	32,36	p53	125,128	MDM2	p53	4193	7157	Gene	Gene	antagonist|nmod|START_ENTITY sensitizes|nsubj|antagonist sensitizes|xcomp|glioblastoma glioblastoma|xcomp|temozolomide temozolomide|nmod|activation activation|compound|END_ENTITY	A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation .
26431162	0	MDM2	42,46	p53	23,26	MDM2	p53	4193	7157	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
26440941	0	MDM2	0,4	p53	35,38	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|Autophagy Autophagy|compound|END_ENTITY	MDM2 Inhibitor , Nutlin 3a , Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation .
26475335	0	MDM2	47,51	p53	52,55	MDM2	p53	4193	7157	Gene	Gene	Inhibitor|nmod|START_ENTITY SAR405838|dep|Inhibitor SAR405838|dep|Axis Axis|compound|END_ENTITY	SAR405838 : A Novel and Potent Inhibitor of the MDM2 : p53 Axis for the Treatment of Dedifferentiated_Liposarcoma .
26492369	0	MDM2	24,28	p53	16,19	MDM2	p53	4193	7157	Gene	Gene	inhibition|compound|START_ENTITY Reactivation|nmod|inhibition Reactivation|nmod|END_ENTITY	Reactivation of p53 via MDM2 inhibition .
26823446	0	MDM2	80,84	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	Interact|nmod|START_ENTITY Have|ccomp|Interact Have|nsubj|mRNA mRNA|compound|END_ENTITY	p53 mRNA and p53 Protein Structures Have Evolved Independently to Interact with MDM2 .
26832796	0	MDM2	117,121	p53	33,36	MDM2	p53	4193	7157	Gene	Gene	inhibitors|nummod|START_ENTITY potentiates|nmod|inhibitors potentiates|nsubj|inhibition inhibition|nmod|END_ENTITY	Chemical inhibition of wild-type p53 induced phosphatase 1 -LRB- WIP1/PPM1D -RRB- by GSK2830371 potentiates the sensitivity to MDM2 inhibitors in a p53-dependent manner .
26840028	0	MDM2	24,28	p53	69,72	MDM2	p53	4193	7157	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|END_ENTITY	microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis .
26998348	0	MDM2	4,8	p53	77,80	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	RG7388|nummod|START_ENTITY leads|nsubj|RG7388 leads|nmod|inhibition inhibition|nmod|neuroblastoma neuroblastoma|compound|END_ENTITY	The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma .
27040927	0	MDM2	37,41	p53	0,3	MDM2	p53	4193	7157	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	p53 expression and relationship with MDM2 amplification in breast_carcinomas .
7618270	0	MDM2	114,118	p53	19,22	MDM2	p53	4193	7157	Gene	Gene	expression|compound|START_ENTITY up-regulation|nmod|expression cause|dobj|up-regulation cause|nsubj|levels levels|nmod|cells cells|nummod|END_ENTITY	The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression .
7624121	0	MDM2	129,133	p53	161,164	MDM2	p53	4193	7157	Gene	Gene	protein|compound|START_ENTITY protein|nmod|arrest arrest|compound|END_ENTITY	Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal_adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation .
7624121	0	MDM2	129,133	p53	59,62	MDM2	p53	4193	7157	Gene	Gene	protein|compound|START_ENTITY induction|nmod|protein demonstrated|nmod|induction dominant|advcl|demonstrated dominant|nmod|END_ENTITY	Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal_adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation .
7624121	0	MDM2	129,133	p53	7,10	MDM2	p53	4193	7157	Gene	Gene	protein|compound|START_ENTITY induction|nmod|protein demonstrated|nmod|induction dominant|advcl|demonstrated dominant|nsubj|END_ENTITY	Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal_adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation .
7698255	0	MDM2	19,23	p53	13,16	MDM2	p53	4193	7157	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|END_ENTITY	Induction of p53 - , MDM2 - , and WAF1/CIP1-like molecules in insect cells by DNA-damaging agents .
7756655	0	MDM2	0,4	p53	68,71	MDM2	p53	4193	7157	Gene	Gene	overexpression|compound|START_ENTITY account|nsubj|overexpression account|nmod|stabilization stabilization|nmod|protein protein|compound|END_ENTITY	MDM2 overexpression does not account for stabilization of wild-type p53 protein in non-Hodgkin 's _ lymphomas .
7888679	0	MDM2	22,26	p53	105,108	MDM2	p53	4193	7157	Gene	Gene	gene|compound|START_ENTITY Overexpression|nmod|gene Overexpression|acl|expressing expressing|dobj|gene gene|compound|END_ENTITY	Overexpression of the MDM2 gene by childhood acute_lymphoblastic_leukemia cells expressing the wild-type p53 gene .
8058315	0	MDM2	55,59	p53	103,106	MDM2	p53	4193	7157	Gene	Gene	p53|nmod|START_ENTITY interaction|nmod|p53 analysis|nmod|interaction analysis|dep|mapping mapping|nmod|site site|nmod|END_ENTITY	Immunochemical analysis of the interaction of p53 with MDM2 ; -- fine mapping of the MDM2 binding site on p53 using synthetic peptides .
8058315	0	MDM2	82,86	p53	103,106	MDM2	p53	4193	7157	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Immunochemical analysis of the interaction of p53 with MDM2 ; -- fine mapping of the MDM2 binding site on p53 using synthetic peptides .
8058315	0	MDM2	82,86	p53	46,49	MDM2	p53	4193	7157	Gene	Gene	site|compound|START_ENTITY mapping|nmod|site analysis|dep|mapping analysis|nmod|interaction interaction|nmod|END_ENTITY	Immunochemical analysis of the interaction of p53 with MDM2 ; -- fine mapping of the MDM2 binding site on p53 using synthetic peptides .
8334996	0	MDM2	98,102	p53	33,36	MDM2	p53	4193	7157	Gene	Gene	p53|dep|START_ENTITY binding|nmod|p53 complexes|amod|binding sites|nmod|complexes identification|nmod|sites DNA|dep|identification DNA|amod|binding binding|nmod|END_ENTITY	Sequence-specific DNA binding by p53 : identification of target sites and lack of binding to p53 - MDM2 complexes .
8350630	0	MDM2	28,32	p53	54,57	MDM2	p53	4193	7157	Gene	Gene	gene|compound|START_ENTITY amplification|nmod|gene Absence|nmod|amplification Absence|appos|regulator regulator|nmod|function function|compound|END_ENTITY	Absence of amplification of MDM2 gene , a regulator of p53 function , in myelodysplastic_syndromes .
8378080	0	MDM2	59,63	p53	30,33	MDM2	p53	4193	7157	Gene	Gene	amplification|compound|START_ENTITY spectrum|nmod|amplification spectrum|nmod|mutations mutations|amod|infrequent infrequent|dep|END_ENTITY	Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing_tumours .
8413278	0	MDM2	106,110	p53	21,24	MDM2	p53	4193	7157	Gene	Gene	protein|compound|START_ENTITY domains|nmod|protein bind|nmod|domains bind|nsubj|END_ENTITY	The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein .
8504413	0	MDM2	40,44	p53	97,100	MDM2	p53	4193	7157	Gene	Gene	gene|compound|START_ENTITY Amplification|nmod|gene Amplification|nmod|mutations mutations|compound|END_ENTITY	Amplification and overexpression of the MDM2 gene in a subset of human malignant_gliomas without p53 mutations .
8570197	0	MDM2	0,4	p53	38,41	MDM2	p53	4193	7157	Gene	Gene	transformation|nummod|START_ENTITY transformation|nmod|absence absence|nmod|END_ENTITY	MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest .
8625108	0	MDM2	22,26	p53	35,38	MDM2	p53	4193	7157	Gene	Gene	gene|compound|START_ENTITY gene|appos|protein protein|compound|END_ENTITY	The expression of the MDM2 gene , a p53 binding protein , in thyroid_carcinogenesis .
8875929	0	MDM2	17,21	p53	47,50	MDM2	p53	4193	7157	Gene	Gene	oncoprotein|compound|START_ENTITY Structure|nmod|oncoprotein bound|nsubj|Structure bound|nmod|domain domain|compound|END_ENTITY	Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain .
8932331	0	MDM2	15,19	p53	70,73	MDM2	p53	4193	7157	Gene	Gene	levels|nmod|START_ENTITY correlated|nsubjpass|levels correlated|nmod|presence presence|nmod|END_ENTITY	High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant_mesothelioma cell lines .
9072003	0	MDM2	105,109	p53	85,88	MDM2	p53	4193	7157	Gene	Gene	+|appos|START_ENTITY status|dep|+ status|compound|END_ENTITY	p21WAF1/CIP1 and MDM2 expression in non-Hodgkin 's _ lymphoma and their relationship to p53 status : a p53 + , MDM2 - , _ p21-immunophenotype associated with missense p53 mutations .
9072003	0	MDM2	105,109	p53	99,102	MDM2	p53	4193	7157	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	p21WAF1/CIP1 and MDM2 expression in non-Hodgkin 's _ lymphoma and their relationship to p53 status : a p53 + , MDM2 - , _ p21-immunophenotype associated with missense p53 mutations .
9178766	0	MDM2	89,93	p53	24,27	MDM2	p53	4193	7157	Gene	Gene	phosphorylation|compound|START_ENTITY effect|nmod|phosphorylation mimics|dobj|effect mimics|nsubj|terminus terminus|nmod|END_ENTITY	The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation .
9363941	0	MDM2	67,71	p53	38,41	MDM2	p53	4193	7157	Gene	Gene	alleviates|nmod|START_ENTITY alleviates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 .
9388063	0	MDM2	19,23	p53	14,17	MDM2	p53	4193	7157	Gene	Gene	bcl-2|dep|START_ENTITY bcl-2|compound|END_ENTITY	Expression of p53 , MDM2 , p21waf1 , bcl-2 , and retinoblastoma gene proteins in myelodysplastic_syndrome after autologous bone marrow_transplantation_for_lymphoma .
9419352	0	MDM2	47,51	p53	26,29	MDM2	p53	4193	7157	Gene	Gene	expression|amod|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage .
9450543	0	MDM2	12,16	p53	63,66	MDM2	p53	4193	7157	Gene	Gene	E3|nsubj|START_ENTITY E3|nmod|END_ENTITY	Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 .
9472631	0	MDM2	97,101	p53	11,14	MDM2	p53	4193	7157	Gene	Gene	gene|compound|START_ENTITY element|nmod|gene derived|nmod|element derived|nsubj|Effects Effects|nmod|mutants mutants|compound|END_ENTITY	Effects of p53 mutants derived from lung_carcinomas on the p53-responsive element -LRB- p53RE -RRB- of the MDM2 gene .
9529248	0	MDM2	85,89	p53	106,109	MDM2	p53	4193	7157	Gene	Gene	inhibition|nmod:poss|START_ENTITY inhibition|nmod|END_ENTITY	The Ink4a tumor suppressor gene product , p19Arf , interacts with MDM2 and neutralizes MDM2 's inhibition of p53 .
9569028	0	MDM2	18,22	p53	90,93	MDM2	p53	4193	7157	Gene	Gene	Overexpression|nmod|START_ENTITY results|nsubj|Overexpression results|nmod|inactivation inactivation|nmod|END_ENTITY	Overexpression of MDM2 , due to enhanced translation , results in inactivation of wild-type p53 in Burkitt 's _ lymphoma cells .
9651526	0	MDM2	0,4	p53	66,69	MDM2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	MDM2 expression during mouse embryogenesis and the requirement of p53 .
9819415	0	MDM2	64,68	p53	57,60	MDM2	p53	4193	7157	Gene	Gene	E6|compound|START_ENTITY required|nmod|E6 required|nmod|degradation degradation|nmod|END_ENTITY	Nuclear export is required for degradation of endogenous p53 by MDM2 and human_papillomavirus E6 .
9875138	0	MDM2	68,72	p53	53,56	MDM2	p53	4193	7157	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	No evidence for functional inactivation of wild-type p53 protein by MDM2 overexpression in gastric_carcinogenesis .
19638586	0	MDM2	20,24	p53-reactivating_drugs_nutlin-3_and_RITA	63,103	MDM2	p53-reactivating drugs nutlin-3 and RITA	4193	84934	Gene	Gene	regulation|nmod|START_ENTITY determines|nsubj|regulation determines|dobj|response response|nmod|END_ENTITY	HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating_drugs_nutlin-3_and_RITA .
19015526	0	MDM2	111,115	p53R2	89,94	MDM2	p53R2	4193	50484	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage .
21093410	0	MDM2	0,4	p73	45,48	MDM2	p73	4193	7161	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells .
19565011	0	MDM2	27,31	p90	32,35	MDM2	p90	4193	57650	Gene	Gene	protein|nummod|START_ENTITY protein|amod|END_ENTITY	Progesterone inhibition of MDM2 p90 protein in MCF-7 human breast_cancer cell line is dependent on p53 levels .
19103650	0	MDM2	66,70	peroxisome_proliferator-activated_receptor-alpha	14,62	MDM2	peroxisome proliferator-activated receptor-alpha	17246(Tax:10090)	19013(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of peroxisome_proliferator-activated_receptor-alpha by MDM2 .
21986500	0	MDM2	0,4	vascular_endothelial_growth_factor	15,49	MDM2	vascular endothelial growth factor	4193	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stabilization stabilization|compound|END_ENTITY	MDM2 regulates vascular_endothelial_growth_factor mRNA stabilization in hypoxia .
25969952	0	MDM2	0,4	vitamin_D_receptor	24,42	MDM2	vitamin D receptor	4193	7421	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	MDM2 binds and inhibits vitamin_D_receptor .
26001071	0	MDM4	99,103	MDM2	38,42	MDM4	MDM2	4194	4193	Gene	Gene	Function|nmod|START_ENTITY Function|compound|END_ENTITY	MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4 .
10626796	0	MDM4	40,44	MDMX	46,50	MDM4	MDMX	4194	4194	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Amplification and overexpression of the MDM4 -LRB- MDMX -RRB- gene from 1q32 in a subset of malignant_gliomas without TP53 mutation or MDM2 amplification .
20697359	0	MDM4	14,18	MDMX	20,24	MDM4	MDMX	4194	4194	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of MDM4 -LRB- MDMX -RRB- function by p76 -LRB- MDM2 -RRB- : a new facet in the control of p53 activity .
22845047	0	MDM4	71,75	TP53	99,103	MDM4	TP53	4194	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	TP53 pathway analysis in paediatric Burkitt_lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases .
23724042	0	MDM4	64,68	miR-191	40,47	MDM4	miR-191	4194	406966	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal_squamous_cell_carcinoma .
20697359	0	MDM4	14,18	p76	38,41	MDM4	p76	4194	196463	Gene	Gene	Regulation|nmod|START_ENTITY function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of MDM4 -LRB- MDMX -RRB- function by p76 -LRB- MDM2 -RRB- : a new facet in the control of p53 activity .
16163388	0	MDMX	42,46	ATM	0,3	MDMX	ATM	4194	472	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage .
18356162	0	MDMX	19,23	Akt	36,39	MDMX	Akt	4194	207	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding .
10218570	0	MDMX	20,24	MDM2	0,4	MDMX	MDM2	4194	4193	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MDM2 interacts with MDMX through their RING finger domains .
10608892	0	MDMX	83,87	MDM2	21,25	MDMX	MDM2	4194	4193	Gene	Gene	protein|compound|START_ENTITY oncoprotein|nmod|protein oncoprotein|nsubj|Stabilization Stabilization|nmod|END_ENTITY	Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein .
12860999	0	MDMX	48,52	MDM2	0,4	MDMX	MDM2	4194	4193	Gene	Gene	ubiquitination|nmod|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	MDM2 promotes ubiquitination and degradation of MDMX .
12963717	0	MDMX	19,23	MDM2	51,55	MDMX	MDM2	4194	4193	Gene	Gene	degradation|compound|START_ENTITY mediated|nsubjpass|degradation mediated|nmod|END_ENTITY	DNA damage-induced MDMX degradation is mediated by MDM2 .
16905541	0	MDMX	0,4	MDM2	51,55	MDMX	MDM2	4194	4193	Gene	Gene	overexpression|compound|START_ENTITY prevents|nsubj|overexpression prevents|nmod|Nutlin Nutlin|compound|END_ENTITY	MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin .
17159902	0	MDMX	75,79	MDM2	51,55	MDMX	MDM2	4194	4193	Gene	Gene	provided|nmod|START_ENTITY provided|nsubjpass|function function|nmod|C-terminus C-terminus|nmod|END_ENTITY	An essential function of the extreme C-terminus of MDM2 can be provided by MDMX .
18520179	0	MDMX	91,95	MDM2	9,13	MDMX	MDM2	4194	4193	Gene	Gene	degradation|compound|START_ENTITY facilitating|dobj|degradation boosts|advcl|facilitating boosts|nsubj|END_ENTITY	Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation .
25659040	0	MDMX	27,31	MDM2	55,59	MDMX	MDM2	4194	4193	Gene	Gene	isoform|compound|START_ENTITY regulates|nsubj|isoform regulates|dobj|activity activity|compound|END_ENTITY	The alternative translated MDMX -LRB- p60 -RRB- isoform regulates MDM2 activity .
8895579	0	MDMX	0,4	MDM2	69,73	MDMX	MDM2	4194	4193	Gene	Gene	START_ENTITY|dep|protein protein|nmod|properties properties|nmod|END_ENTITY	MDMX : a novel p53-binding protein with some functional properties of MDM2 .
10626796	0	MDMX	46,50	MDM4	40,44	MDMX	MDM4	4194	4194	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Amplification and overexpression of the MDM4 -LRB- MDMX -RRB- gene from 1q32 in a subset of malignant_gliomas without TP53 mutation or MDM2 amplification .
20697359	0	MDMX	20,24	MDM4	14,18	MDMX	MDM4	4194	4194	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MDM4 -LRB- MDMX -RRB- function by p76 -LRB- MDM2 -RRB- : a new facet in the control of p53 activity .
10075736	0	MDMX	8,12	p53	113,116	MDMX	p53	4194	7157	Gene	Gene	transcript|compound|START_ENTITY encodes|nsubj|transcript encodes|nmod|activity activity|compound|END_ENTITY	A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity .
12162806	0	MDMX	0,4	p53	51,54	MDMX	p53	4194	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|acetylation acetylation|nmod|END_ENTITY	MDMX inhibits the p300/CBP-mediated acetylation of p53 .
14660608	0	MDMX	6,10	p53	68,71	MDMX	p53	17248(Tax:10090)	22060(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY enhances|nsubj|overexpression enhances|dobj|stabilization stabilization|nmod|END_ENTITY	MDM4 -LRB- MDMX -RRB- overexpression enhances stabilization of stress-induced p53 and promotes apoptosis .
16163388	0	MDMX	42,46	p53	61,64	MDMX	p53	4194	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY contribute|nsubj|phosphorylation contribute|nmod|activation activation|compound|END_ENTITY	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage .
16511572	0	MDMX	21,25	p53	84,87	MDMX	p53	4194	7157	Gene	Gene	START_ENTITY|acl:relcl|phosphorylated phosphorylated|xcomp|resulting resulting|nmod|activation activation|compound|END_ENTITY	14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1 , resulting in p53 activation .
16905541	0	MDMX	0,4	p53	29,32	MDMX	p53	4194	7157	Gene	Gene	overexpression|compound|START_ENTITY prevents|nsubj|overexpression prevents|dobj|activation activation|compound|END_ENTITY	MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin .
17110929	0	MDMX	0,4	p53	19,22	MDMX	p53	17248(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|response response|compound|END_ENTITY	MDMX regulation of p53 response to ribosomal stress .
17327702	0	MDMX	18,22	p53	44,47	MDMX	p53	4194	7157	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|regulation regulation|nmod|response response|compound|END_ENTITY	Distinct roles of MDMX in the regulation of p53 response to ribosomal stress .
20697359	0	MDMX	20,24	p53	79,82	MDMX	p53	4194	7157	Gene	Gene	Regulation|appos|START_ENTITY function|nsubj|Regulation function|nmod|p76 p76|dep|facet facet|nmod|control control|nmod|activity activity|compound|END_ENTITY	Regulation of MDM4 -LRB- MDMX -RRB- function by p76 -LRB- MDM2 -RRB- : a new facet in the control of p53 activity .
21075910	0	MDMX	30,34	p53	45,48	MDMX	p53	4194	7157	Gene	Gene	inhibitor|nmod|START_ENTITY activates|nsubj|inhibitor activates|dobj|END_ENTITY	A small-molecule inhibitor of MDMX activates p53 and induces apoptosis .
21750655	0	MDMX	68,72	p53	17,20	MDMX	p53	4194	7157	Gene	Gene	expression|compound|START_ENTITY inhibiting|dobj|expression induces|advcl|inhibiting induces|nsubj|activator activator|compound|END_ENTITY	A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast_cancer cells .
23028042	0	MDMX	30,34	p53	75,78	MDMX	p53	4194	7157	Gene	Gene	interaction|compound|START_ENTITY regulates|dobj|interaction regulates|xcomp|stimulate stimulate|dobj|END_ENTITY	Casein kinase 1a regulates an MDMX intramolecular interaction to stimulate p53 binding .
24190973	0	MDMX	60,64	p53	37,40	MDMX	p53	4194	7157	Gene	Gene	phosphorylating|dobj|START_ENTITY induces|advcl|phosphorylating induces|dobj|END_ENTITY	AMP-activated_protein_kinase induces p53 by phosphorylating MDMX and inhibiting its activity .
25825738	0	MDMX	18,22	p53	41,44	MDMX	p53	4194	7157	Gene	Gene	Autoinhibition|nmod|START_ENTITY Autoinhibition|nmod|mimicry mimicry|compound|END_ENTITY	Autoinhibition of MDMX by intramolecular p53 mimicry .
26148237	0	MDMX	39,43	p53	70,73	MDMX	p53	4194	7157	Gene	Gene	phosphorylation|compound|START_ENTITY activates|nsubj|phosphorylation activates|dobj|END_ENTITY	Structural basis of how stress-induced MDMX phosphorylation activates p53 .
16007679	0	MDP77	75,80	muscle-derived_protein_with_molecular_mass_of_77_kDa	21,73	MDP77	muscle-derived protein with molecular mass of 77 kDa	167838	167838	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Long-term effects of muscle-derived_protein_with_molecular_mass_of_77_kDa -LRB- MDP77 -RRB- on nerve regeneration .
2002063	0	MDR	67,70	MDR3	23,27	MDR	MDR3	18669(Tax:10090)	5244	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Structure of the human MDR3 gene and physical mapping of the human MDR locus .
22907429	0	MDR-1	30,35	HOXC6	39,44	MDR-1	HOXC6	5243	3223	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of MDR-1 by HOXC6 in multidrug-resistant cells .
12138126	0	MDR-1	14,19	P-glycoprotein	21,35	MDR-1	P-glycoprotein	24646(Tax:10116)	287115(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of MDR-1 -LRB- P-glycoprotein -RRB- by cyclooxygenase-2 .
8590843	0	MDR-1	14,19	P-glycoprotein	20,34	MDR-1	P-glycoprotein	5243	5243	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of MDR-1 / P-glycoprotein in childhood acute_megakaryoblastic_leukemia cells .
12138126	0	MDR-1	14,19	cyclooxygenase-2	40,56	MDR-1	cyclooxygenase-2	24646(Tax:10116)	29527(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MDR-1 -LRB- P-glycoprotein -RRB- by cyclooxygenase-2 .
15507937	0	MDR-1	192,197	multidrug_resistance-1	168,190	MDR-1	multidrug resistance-1	5243	5243	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Internalization of cytotoxic analog AN-152 of luteinizing_hormone-releasing_hormone induces apoptosis in human endometrial_and_ovarian_cancer cell lines independent of multidrug_resistance-1 -LRB- MDR-1 -RRB- system .
9618515	0	MDR-1	43,48	p-glycoprotein	27,41	MDR-1	p-glycoprotein	5243	5243	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	A physiologic function for p-glycoprotein -LRB- MDR-1 -RRB- during the migration of dendritic cells from skin via afferent lymphatic vessels .
10500781	0	MDR-1_and_MDR-3	42,57	Pgp	58,61	MDR-1 and MDR-3	Pgp	5243;5244	283871	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Preliminary immunocytochemical studies of MDR-1_and_MDR-3 Pgp expression in B-cell_leukaemias .
12112526	0	MDR1	60,64	ABCB1	66,71	MDR1	ABCB1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Preferential expression of a mutant allele of the amplified MDR1 -LRB- ABCB1 -RRB- gene in drug-resistant variants of a human sarcoma .
12352921	0	MDR1	113,117	ABCB1	106,111	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Neurotoxicity induced by tacrolimus after liver transplantation : relation to genetic polymorphisms of the ABCB1 -LRB- MDR1 -RRB- gene .
12893986	0	MDR1	63,67	ABCB1	56,61	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence diversity and haplotype structure in the human ABCB1 -LRB- MDR1 , multidrug_resistance_transporter -RRB- gene .
15228162	0	MDR1	24,28	ABCB1	30,35	MDR1	ABCB1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical aspects of the MDR1 -LRB- ABCB1 -RRB- gene polymorphism .
15280437	0	MDR1	90,94	ABCB1	96,101	MDR1	ABCB1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 -LRB- ABCB1 -RRB- gene .
15692830	0	MDR1	42,46	ABCB1	35,40	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphisms of ABCB1 -LRB- MDR1 -RRB- gene and distinct haplotype profile in a West Black African population .
16431292	0	MDR1	17,21	ABCB1	10,15	MDR1	ABCB1	5243	5243	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of ABCB1 -LRB- MDR1 -RRB- haplotypes on tacrolimus dosing in adult lung transplant patients who are CYP3A5 * 3 / * 3 non-expressors .
16797284	0	MDR1	14,18	ABCB1	20,25	MDR1	ABCB1	5243	5243	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of MDR1 -LRB- ABCB1 -RRB- polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients .
16869811	0	MDR1	17,21	ABCB1	10,15	MDR1	ABCB1	5243	5243	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of ABCB1 -LRB- MDR1 -RRB- haplotypes derived from G2677T/C3435T on the pharmacokinetics of amlodipine in healthy subjects .
17038891	0	MDR1	31,35	ABCB1	24,29	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No influence of 3435C > T ABCB1 -LRB- MDR1 -RRB- gene polymorphism on risk of adult_acute_myeloid_leukemia and P-glycoprotein expression in blast cells .
17085864	0	MDR1	0,4	ABCB1	6,11	MDR1	ABCB1	5243	5243	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	MDR1 -LRB- ABCB1 -RRB- gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell_chronic_lymphocytic_leukemia .
17225463	0	MDR1	86,90	ABCB1	79,84	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analyses of single nucleotide polymorphisms and haplotype linkage of the human ABCB1 -LRB- MDR1 -RRB- gene in Korean .
17377214	0	MDR1	17,21	ABCB1	10,15	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Impact of ABCB1 -LRB- MDR1 -RRB- gene polymorphism and P-glycoprotein inhibitors on digoxin serum concentration in congestive heart_failure patients .
17913323	0	MDR1	7,11	ABCB1	0,5	MDR1	ABCB1	5243	5243	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	ABCB1 -LRB- MDR1 -RRB- gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive_disorder .
18003028	0	MDR1	49,53	ABCB1	54,59	MDR1	ABCB1	5243	5243	Gene	Gene	GENE|compound|START_ENTITY GENE|appos|END_ENTITY	MDRView : a visualization of the polymorphisms of MDR1 -LRB- ABCB1 -RRB- GENE in breast_cancer .
18436433	0	MDR1	128,132	ABCB1	121,126	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multidrug resistance in patients undergoing resective epilepsy surgery is not associated with C3435T polymorphism in the ABCB1 -LRB- MDR1 -RRB- gene .
19005421	0	MDR1	44,48	ABCB1	50,55	MDR1	ABCB1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations between common variants in the MDR1 -LRB- ABCB1 -RRB- gene and ulcerative_colitis among North Indians .
19714749	0	MDR1	24,28	ABCB1	30,35	MDR1	ABCB1	5243	5243	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High gene expression of MDR1 -LRB- ABCB1 -RRB- is associated with medical treatment response and long-term remission in patients with ulcerative_colitis .
20520719	0	MDR1	21,25	ABCB1	14,19	MDR1	ABCB1	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Inhibition of ABCB1 -LRB- MDR1 -RRB- expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma .
21851199	0	MDR1	27,31	ABCB1	20,25	MDR1	ABCB1	5243	5243	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between ABCB1 -LRB- MDR1 -RRB- gene 3435_C > T polymorphism and colchicine unresponsiveness of FMF patients .
21987299	0	MDR1	44,48	ABCB1	37,42	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations between variants in the ABCB1 -LRB- MDR1 -RRB- gene and corticosteroid dependence in children with Crohn 's _ disease .
23930592	0	MDR1	48,52	ABCB1	54,59	MDR1	ABCB1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genotype variability and haplotype frequency of MDR1 -LRB- ABCB1 -RRB- gene polymorphism in Morocco .
24413370	0	MDR1	87,91	ABCB1	93,98	MDR1	ABCB1	5243	5243	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Hepatopathy-Thrombocytopenia_Syndrome During Actinomycin_D Treatment May Be Related to MDR1 -LRB- ABCB1 -RRB- Gene Polymorphisms .
25725700	0	MDR1	53,57	ABCB1	46,51	MDR1	ABCB1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genotype variability and haplotype profile of ABCB1 -LRB- MDR1 -RRB- gene polymorphisms in macedonian population .
22504573	0	MDR1	31,35	C3435	36,41	MDR1	C3435	5243	1039312(Tax:199310)	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Meta-analysis of the effect of MDR1 C3435 polymorphism on tacrolimus pharmacokinetics in renal transplant recipients .
22049617	0	MDR1	86,90	CD133	79,84	MDR1	CD133	5243	8842	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Isolation , characterization and mobilization of prostate_cancer tissue derived CD133 + MDR1 + cells .
25823028	0	MDR1	26,30	CD133	0,5	MDR1	CD133	5243	8842	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	CD133 and DNA-PK regulate MDR1 via the PI3K - or Akt-NF-kB pathway in multidrug-resistant glioblastoma cells in vitro .
16220110	0	MDR1	24,28	CYP2C19	8,15	MDR1	CYP2C19	5243	1557	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	CYP2C9 , CYP2C19 , ABCB1 -LRB- MDR1 -RRB- genetic polymorphisms and phenytoin metabolism in a Black Beninese population .
14676821	0	MDR1	55,59	CYP2C9	32,38	MDR1	CYP2C9	5243	1559	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	Warfarin sensitivity related to CYP2C9 , CYP3A5 , ABCB1 -LRB- MDR1 -RRB- and other factors .
16220110	0	MDR1	24,28	CYP2C9	0,6	MDR1	CYP2C9	5243	1559	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	CYP2C9 , CYP2C19 , ABCB1 -LRB- MDR1 -RRB- genetic polymorphisms and phenytoin metabolism in a Black Beninese population .
12172213	0	MDR1	27,31	CYP3A4	80,86	MDR1	CYP3A4	5243	1576	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene affects|nsubj|polymorphism affects|dobj|level level|nmod|END_ENTITY	C3435T polymorphism in the MDR1 gene affects the enterocyte expression level of CYP3A4 rather than Pgp in recipients of living-donor liver transplantation .
12625868	0	MDR1	45,49	CYP3A4	19,25	MDR1	CYP3A4	5243	1576	Gene	Gene	ABC-transporters|appos|START_ENTITY ABC-transporters|compound|END_ENTITY	Gene expression of CYP3A4 , ABC-transporters -LRB- MDR1 and MRP1-MRP5 -RRB- and hPXR in three different human colon_carcinoma cell lines .
18636247	0	MDR1	15,19	CYP3A4	21,27	MDR1	CYP3A4	5243	1576	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of MDR1 , CYP3A4 * 18B , and CYP3A5 * 3 polymorphisms with cyclosporine pharmacokinetics in Chinese_renal_transplant_recipients .
19267185	0	MDR1	0,4	CYP3A4	65,71	MDR1	CYP3A4	5243	1576	Gene	Gene	haplotypes|nsubj|START_ENTITY haplotypes|xcomp|conferring conferring|dobj|expression expression|nmod|END_ENTITY	MDR1 haplotypes conferring an increased expression of intestinal CYP3A4 rather than MDR1 in female living-donor liver transplant patients .
14676821	0	MDR1	55,59	CYP3A5	40,46	MDR1	CYP3A5	5243	1577	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Warfarin sensitivity related to CYP2C9 , CYP3A5 , ABCB1 -LRB- MDR1 -RRB- and other factors .
23542036	0	MDR1	18,22	E2F1	35,39	MDR1	E2F1	5243	1869	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the MDR1 promoter by E2F1 and EAPP .
23478574	0	MDR1	62,66	Egr-1	0,5	MDR1	Egr-1	5243	1958	Gene	Gene	expression|compound|START_ENTITY modulating|dobj|expression enhances|advcl|modulating enhances|nsubj|END_ENTITY	Egr-1 enhances drug resistance of breast_cancer by modulating MDR1 expression in a GGPPS-independent manner .
21538359	0	MDR1	0,4	GCS	43,46	MDR1	GCS	5243	7357	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	MDR1 -LRB- multidrug_resistence_1 -RRB- can regulate GCS -LRB- glucosylceramide_synthase -RRB- in breast_cancer cells .
15252144	0	MDR1	21,25	MDR3	38,42	MDR1	MDR3	5243	5244	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Inhibition of ABCB1 -LRB- MDR1 -RRB- and ABCB4 -LRB- MDR3 -RRB- expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian_cancer cells .
11077043	0	MDR1	191,195	MT-II	220,225	MDR1	MT-II	5243	4502	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Increased mRNA levels of xeroderma_pigmentosum_complementation_group_B -LRB- XPB -RRB- and Cockayne 's _ syndrome complementation group B -LRB- CSB -RRB- without increased mRNA levels of multidrug-resistance gene -LRB- MDR1 -RRB- or metallothionein-II -LRB- MT-II -RRB- in platinum-resistant human ovarian_cancer tissues .
21127835	0	MDR1	25,29	Multi_drug_resistance-1	0,23	MDR1	Multi drug resistance-1	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Multi_drug_resistance-1 -LRB- MDR1 -RRB- expression in response to chronic diazinon exposure : an in vitro study on Caco-2 cells .
25816099	0	MDR1	53,57	Multidrug_Resistance	31,51	MDR1	Multidrug Resistance	5243	5243	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	The Roles of Variants in Human Multidrug_Resistance -LRB- MDR1 -RRB- Gene and Their Haplotypes on Antiepileptic Drugs Response : A Meta-Analysis of 57 Studies .
8709631	0	MDR1	24,28	Multidrug_resistance-1	0,22	MDR1	Multidrug resistance-1	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Multidrug_resistance-1 -LRB- MDR1 -RRB- expression and functional dye/drug efflux is highly correlated with the t -LRB- 8 ; 21 -RRB- chromosomal translocation in pediatric acute_myeloid_leukemia .
27039718	0	MDR1	23,27	NOS3	17,21	MDR1	NOS3	5243	4846	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|appos|END_ENTITY	Effects of TNFa , NOS3 , MDR1 Gene Polymorphisms on Clinical Parameters , Prognosis and Survival of Multiple_Myeloma Cases .
25932627	0	MDR1	118,122	P-Glycoprotein	16,30	MDR1	P-Glycoprotein	5243	67078(Tax:10090)	Gene	Gene	Quantification|nmod|START_ENTITY Humanized|nmod|Quantification Humanized|nsubj|Validation Validation|nmod|P-gp P-gp|amod|END_ENTITY	Validation of a P-Glycoprotein -LRB- P-gp -RRB- Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1 , Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport .
10384961	0	MDR1	63,67	P-glycoprotein	68,82	MDR1	P-glycoprotein	5243	5243	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Epitope mapping of the monoclonal antibody MM12 .10 to external MDR1 P-glycoprotein domain by synthetic peptide scanning and phage display technologies .
10581184	0	MDR1	34,38	P-glycoprotein	61,75	MDR1	P-glycoprotein	18669(Tax:10090)	67078(Tax:10090)	Gene	Gene	resistant|dep|START_ENTITY leukemia|amod|resistant multidrug|dobj|leukemia multidrug|nmod|substrates substrates|amod|END_ENTITY	Treatment of multidrug resistant -LRB- MDR1 -RRB- murine leukemia with P-glycoprotein substrates accelerates the course of the disease .
10755319	0	MDR1	101,105	P-glycoprotein	85,99	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Effect of high-dose cyclosporine on etoposide pharmacodynamics in a trial to reverse P-glycoprotein -LRB- MDR1 gene -RRB- mediated drug resistance .
11160305	0	MDR1	9,13	P-glycoprotein	14,28	MDR1	P-glycoprotein	5243	5243	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro .
11240981	0	MDR1	84,88	P-glycoprotein	52,66	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects .
11369136	0	MDR1	26,30	P-glycoprotein	114,128	MDR1	P-glycoprotein	18669(Tax:10090)	67078(Tax:10090)	Gene	Gene	apoptosis|nmod|START_ENTITY Induction|nmod|apoptosis expressing|nsubj|Induction expressing|nmod|combinations combinations|nmod|concentrations concentrations|nmod|modulators modulators|amod|END_ENTITY	Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P-glycoprotein modulators .
11391622	0	MDR1	51,55	P-glycoprotein	35,49	MDR1	P-glycoprotein	5243	5243	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug-resistance P-glycoprotein -LRB- MDR1 -RRB- in human brain_tumors .
11678332	0	MDR1	28,32	P-glycoprotein	12,26	MDR1	P-glycoprotein	5243	5243	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of P-glycoprotein -LRB- MDR1 -RRB- polymorphisms and mutations in colorectal_cancer .
12426522	0	MDR1	83,87	P-glycoprotein	68,82	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene .
12525496	0	MDR1	16,20	P-glycoprotein	0,14	MDR1	P-glycoprotein	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	P-glycoprotein -LRB- MDR1 -RRB- expression in leukemic cells is regulated at two distinct steps , mRNA stabilization and translational initiation .
12724617	0	MDR1	52,56	P-glycoprotein	20,34	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the P-glycoprotein drug transporter MDR1 gene : a possible link between environmental and genetic factors in Parkinson 's _ disease .
1346497	0	MDR1	16,20	P-glycoprotein	22,36	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The role of the MDR1 -LRB- P-glycoprotein -RRB- gene in multidrug resistance in vitro and in vivo .
1359152	0	MDR1	23,27	P-glycoprotein	29,43	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Clinical correlates of MDR1 -LRB- P-glycoprotein -RRB- gene expression in ovarian_and_small-cell_lung_carcinomas .
1360276	0	MDR1	14,18	P-glycoprotein	20,34	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Activation of MDR1 -LRB- P-glycoprotein -RRB- gene expression in human cells by protein_kinase_C agonists .
15695797	0	MDR1	73,77	P-glycoprotein	78,92	MDR1	P-glycoprotein	18669(Tax:10090)	5243	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo : validation in multidrug-resistant tumors and at the blood-brain barrier .
15824923	0	MDR1	65,69	P-glycoprotein	14,28	MDR1	P-glycoprotein	403879(Tax:9615)	610926(Tax:9615)	Gene	Gene	resistance|compound|START_ENTITY function|nmod|resistance function|nsubj|Inhibition Inhibition|nmod|transport transport|amod|END_ENTITY	Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin .
15912392	0	MDR1	52,56	P-glycoprotein	20,34	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon_cancer patients .
16998727	0	MDR1	48,52	P-glycoprotein	54,68	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of multidrug resistance type 1 gene -LRB- MDR1 -RRB- P-glycoprotein in intractable epilepsy with different aetiologies : a double-labelling and electron microscopy study .
1704872	0	MDR1	74,78	P-glycoprotein	93,107	MDR1	P-glycoprotein	5243	5243	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product -LRB- P-glycoprotein -RRB- : determination of P-glycoprotein expression in multi-drug-resistant KB and CEM cell variants .
17085864	0	MDR1	0,4	P-glycoprotein	57,71	MDR1	P-glycoprotein	5243	5243	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|activity activity|amod|END_ENTITY	MDR1 -LRB- ABCB1 -RRB- gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell_chronic_lymphocytic_leukemia .
17268526	0	MDR1	77,81	P-glycoprotein	96,110	MDR1	P-glycoprotein	5243	5243	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	The farnesyl transferase inhibitor , tipifarnib , is a potent inhibitor of the MDR1 gene product , P-glycoprotein , and demonstrates significant cytotoxic synergism against human leukemia cell lines .
17556798	0	MDR1	52,56	P-glycoprotein	20,34	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the P-glycoprotein drug transporter MDR1 gene in renal transplant patients treated with cyclosporin_A in a Polish population .
17933684	0	MDR1	83,87	P-glycoprotein	60,74	MDR1	P-glycoprotein	18669(Tax:10090)	67078(Tax:10090)	Gene	Gene	ABCB1|dep|START_ENTITY protein|appos|ABCB1 protein|appos|END_ENTITY	Drug-drug interactions affected by the transporter protein , P-glycoprotein -LRB- ABCB1 , MDR1 -RRB- I. Preclinical aspects .
17955490	0	MDR1	38,42	P-glycoprotein	14,28	MDR1	P-glycoprotein	5243	5243	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast_cancer .
18054347	0	MDR1	88,92	P-glycoprotein	8,22	MDR1	P-glycoprotein	396910(Tax:9823)	5243	Gene	Gene	cells|nummod|START_ENTITY Role|nmod|cells Role|nmod|END_ENTITY	Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung_adenocarcinoma cells .
18605086	0	MDR1	17,21	P-glycoprotein	22,36	MDR1	P-glycoprotein	5243	5243	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Detection of the MDR1 P-glycoprotein expression and function .
26286731	0	MDR1	115,119	P-glycoprotein	121,135	MDR1	P-glycoprotein	5243	5243	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	The Role of Multidrug Resistance Efflux Pumps in Cancer : Revisiting a JNCI Publication Exploring Expression of the MDR1 -LRB- P-glycoprotein -RRB- Gene .
8099226	0	MDR1	18,22	P-glycoprotein	29,43	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY Expression|nmod|gene Expression|appos|END_ENTITY	Expression of the MDR1 gene -LRB- P-glycoprotein -RRB- in breast cancer .
8103760	0	MDR1	74,78	P-glycoprotein	80,94	MDR1	P-glycoprotein	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variable effects of sodium_butyrate on the expression and function of the MDR1 -LRB- P-glycoprotein -RRB- gene in colon_carcinoma cell lines .
8575863	0	MDR1	102,106	P-glycoprotein	54,68	MDR1	P-glycoprotein	18669(Tax:10090)	67078(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY proliferation|nmod|gene expressing|nsubj|proliferation blockers|advcl|expressing blockers|nsubj|Effect Effect|nmod|combination combination|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of MDR1 gene expressing cells .
8900436	0	MDR1	33,37	P-glycoprotein	39,53	MDR1	P-glycoprotein	5243	5243	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of cytarabine-induced MDR1 -LRB- P-glycoprotein -RRB- gene activation in human tumor cells by fatty_acid-polyethylene glycol-fatty_acid diesters , novel inhibitors of P-glycoprotein function .
16122788	0	MDR1	0,4	P-gp	5,9	MDR1	P-gp	5243	283871	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MDR1 P-gp expression and activity in intact human placental tissue ; upregulation by retroviral transduction .
22206665	0	MDR1	130,134	PC3	87,90	MDR1	PC3	5243	5122	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	ETS1 promotes chemoresistance and invasion of paclitaxel-resistant , hormone-refractory PC3 prostate cancer cells by up-regulating MDR1 and MMP9 expression .
26876203	0	MDR1	16,20	Pygo2	0,5	MDR1	Pygo2	5243	90780	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Pygo2 activates MDR1 expression and mediates chemoresistance in breast_cancer via the Wnt/b-catenin pathway .
9667638	0	MDR1	41,45	RAR_alpha	23,32	MDR1	RAR alpha	5243	5914	Gene	Gene	expression|compound|START_ENTITY gene|nmod|expression gene|compound|END_ENTITY	Influence of exogenous RAR_alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines .
15910691	0	MDR1	30,34	RARalpha	13,21	MDR1	RARalpha	5243	5914	Gene	Gene	expression|compound|START_ENTITY gene|nmod|expression gene|compound|END_ENTITY	Influence of RARalpha gene on MDR1 expression and P-glycoprotein function in human leukemic cells .
8103518	0	MDR1	18,22	SP1	0,3	MDR1	SP1	5243	6667	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity .
20037778	0	MDR1	15,19	UHRF1	0,5	MDR1	UHRF1	5243	29128	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	UHRF1 inhibits MDR1 gene transcription and sensitizes breast_cancer cells to anticancer drugs .
16006237	0	MDR1	82,86	constitutive_androstane_receptor	11,43	MDR1	constitutive androstane receptor	5243	9970	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression role|nmod|regulation role|nmod|END_ENTITY	A role for constitutive_androstane_receptor in the regulation of human intestinal MDR1 expression .
10806806	0	MDR1	46,50	multi-drug_resistance_gene	18,44	MDR1	multi-drug resistance gene	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical study of multi-drug_resistance_gene -LRB- MDR1 -RRB- expression in primary ovarian_cancer .
11039467	0	MDR1	42,46	multidrug-resistance_1	18,40	MDR1	multidrug-resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the multidrug-resistance_1 -LRB- MDR1 -RRB- gene and prognosis in human pancreatic_cancer .
11426620	0	MDR1	28,32	multidrug_resistance	34,54	MDR1	multidrug resistance	5243	5243	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Differential effects of the MDR1 -LRB- multidrug_resistance -RRB- gene-activating agents on protein_kinase_C : evidence for redundancy of mechanisms of acquired MDR in leukemia cells .
11990778	0	MDR1	60,64	multidrug_resistance	38,58	MDR1	multidrug resistance	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphisms of the human multidrug_resistance -LRB- MDR1 -RRB- gene : correlation with P_glycoprotein expression and activity in vivo .
1360648	0	MDR1	108,112	multidrug_resistance	86,106	MDR1	multidrug resistance	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Purification and characterization of NF-R1 that regulates the expression of the human multidrug_resistance -LRB- MDR1 -RRB- gene .
17519790	0	MDR1	44,48	multidrug_resistance	17,37	MDR1	multidrug resistance	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of multidrug_resistance gene -LRB- MDR1 -RRB- and cyclosporine absorption in de novo renal transplant patients .
1976252	0	MDR1	25,29	multidrug_resistance	31,51	MDR1	multidrug resistance	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Quantitative analysis of MDR1 -LRB- multidrug_resistance -RRB- gene expression in human tumors by polymerase chain reaction .
7949467	0	MDR1	51,55	multidrug_resistance	29,49	MDR1	multidrug resistance	5243	5243	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Transactivation of the human multidrug_resistance -LRB- MDR1 -RRB- gene promoter by p53 mutants .
8098026	0	MDR1	108,112	multidrug_resistance	86,106	MDR1	multidrug resistance	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Purification and characterization of NF-R2 that regulates the expression of the human multidrug_resistance -LRB- MDR1 -RRB- gene .
8387754	0	MDR1	13,17	multidrug_resistance	19,39	MDR1	multidrug resistance	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Analysis of MDR1 -LRB- multidrug_resistance -RRB- gene expression by RT-PCR -RSB- .
9375821	0	MDR1	14,18	multidrug_resistance	20,40	MDR1	multidrug resistance	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Expression of MDR1 -LRB- multidrug_resistance -RRB- gene and its protein in normal human kidney .
9384659	0	MDR1	16,20	multidrug_resistance	22,42	MDR1	multidrug resistance	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transfer of the MDR1 -LRB- multidrug_resistance -RRB- gene : protection of hematopoietic cells from cytotoxic chemotherapy , and selection of transduced cells in vivo .
15081455	0	MDR1	45,49	multidrug_resistance-1	21,43	MDR1	multidrug resistance-1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the multidrug_resistance-1 -LRB- MDR1 -RRB- gene influence the response to atorvastatin treatment in a gender-specific manner .
10933203	0	MDR1	109,113	multidrug_resistance_1	80,102	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical scale production of an improved retroviral vector expressing the human multidrug_resistance_1 gene -LRB- MDR1 -RRB- .
15115917	0	MDR1	131,135	multidrug_resistance_1	102,124	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug_resistance_1 gene -LRB- MDR1 , ABCB1 -RRB- .
15505619	0	MDR1	41,45	multidrug_resistance_1	17,39	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in multidrug_resistance_1 -LRB- MDR1 -RRB- gene are associated with refractory Crohn_disease and ulcerative_colitis .
17118775	0	MDR1	50,54	multidrug_resistance_1	26,48	MDR1	multidrug resistance 1	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chemoprotection effect of multidrug_resistance_1 -LRB- MDR1 -RRB- gene transfer to hematopoietic progenitor cells and engrafted in mice with cancer allows intensified chemotherapy .
17568669	0	MDR1	52,56	multidrug_resistance_1	28,50	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulatory polymorphisms of multidrug_resistance_1 -LRB- MDR1 -RRB- gene are associated with the development of childhood acute_lymphoblastic_leukemia .
19250544	0	MDR1	28,32	multidrug_resistance_1	4,26	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The multidrug_resistance_1 -LRB- MDR1 -RRB- gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal_adenoma and colorectal_cancer ; a case control study .
19331170	0	MDR1	58,62	multidrug_resistance_1	34,56	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effect of promoter methylation of multidrug_resistance_1 -LRB- MDR1 -RRB- gene in gastric_carcinogenesis .
20840328	0	MDR1	81,85	multidrug_resistance_1	57,79	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of steroid_and_xenobiotic_receptor -LRB- SXR -RRB- and multidrug_resistance_1 -LRB- MDR1 -RRB- gene expression with survival among patients with invasive bladder_carcinoma .
25544376	0	MDR1	55,59	multidrug_resistance_1	31,53	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Differential expression of the multidrug_resistance_1 -LRB- MDR1 -RRB- protein in prostate_cancer cells is independent from anticancer drug treatment and Y_box_binding_protein_1 -LRB- YB-1 -RRB- activity .
9292393	0	MDR1	55,59	multidrug_resistance_1	31,53	MDR1	multidrug resistance 1	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Quantitative analysis of human multidrug_resistance_1 -LRB- MDR1 -RRB- gene expression by nonisotopic competitive reverse transcriptase polymerase chain reaction assay .
11254880	0	MDR1	60,64	multidrug_resistance_associated_transporters	14,58	MDR1	multidrug resistance associated transporters	5243	5243	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance_associated_transporters -LRB- MDR1 , MRP1 , LRP and BCRP -RRB- in porcine oocyte .
1349537	0	MDR1	85,89	multidrug_resistance_gene	58,83	MDR1	multidrug resistance gene	5243	5243	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Quercetin , a bioflavonoid , inhibits the increase of human multidrug_resistance_gene -LRB- MDR1 -RRB- expression caused by arsenite .
23876050	0	MDR1	56,60	multidrug_resistance_gene	29,54	MDR1	multidrug resistance gene	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Small molecule inhibitors of multidrug_resistance_gene -LRB- MDR1 -RRB- expression : preclinical evaluation and mechanisms of action .
7912240	0	MDR1	45,49	multidrug_resistance_gene	18,43	MDR1	multidrug resistance gene	5243	5243	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the multidrug_resistance_gene -LRB- MDR1 -RRB- in non-small cell lung_cancer .
22363234	0	MDR1	101,105	multiple_drug_resistance_1	73,99	MDR1	multiple drug resistance 1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
18540626	0	MDR1	51,55	pregnane_X_receptor	14,33	MDR1	pregnane X receptor	5243	8856	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of pregnane_X_receptor and induction of MDR1 by dietary phytochemicals .
19273348	0	MDR3	26,30	ABCB4	32,37	MDR3	ABCB4	5244	5244	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Liver_diseases related to MDR3 -LRB- ABCB4 -RRB- gene deficiency .
14527955	0	MDR3	70,74	Farnesoid_X_receptor	0,20	MDR3	Farnesoid X receptor	5244	9971	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Farnesoid_X_receptor activates transcription of the phospholipid pump MDR3 .
2002063	0	MDR3	23,27	MDR	67,70	MDR3	MDR	5244	18669(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Structure of the human MDR3 gene and physical mapping of the human MDR locus .
15252144	0	MDR3	38,42	MDR1	21,25	MDR3	MDR1	5244	5243	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Inhibition of ABCB1 -LRB- MDR1 -RRB- and ABCB4 -LRB- MDR3 -RRB- expression by small interfering RNA and reversal of paclitaxel resistance in human ovarian_cancer cells .
14585371	0	MDS1-EVI1-like-1	18,34	EL1	59,62	MDS1-EVI1-like-1	EL1	63976	2035	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Low expression of MDS1-EVI1-like-1 -LRB- MEL1 -RRB- and EVI1-like-1 -LRB- EL1 -RRB- genes in favorable-risk acute_myeloid_leukemia .
15018808	0	ME1	51,54	Tcf12	44,49	ME1	Tcf12	17436(Tax:10090)	21406(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the bHLH transcription factor Tcf12 -LRB- ME1 -RRB- gene is linked to the expansion of precursor cell populations during neurogenesis .
17405739	0	ME1	37,40	Tcf12	30,35	ME1	Tcf12	17436(Tax:10090)	21406(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	The bHLH transcription factor Tcf12 -LRB- ME1 -RRB- mRNA is abundantly expressed in Paneth cells of mouse intestine .
22445368	0	ME1	45,48	malic_enzyme_1	28,42	ME1	malic enzyme 1	100860863	100860863	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism of the caprine malic_enzyme_1 -LRB- ME1 -RRB- gene and its association with milk quality traits in Murciano-Granadina goats .
7545545	0	MEC1	136,140	TEL1	0,4	MEC1	TEL1	852433(Tax:4932)	852190(Tax:4932)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	TEL1 , an S. _ cerevisiae homolog of the human gene mutated in ataxia_telangiectasia , is functionally related to the yeast checkpoint gene MEC1 .
19217433	0	MECP2	96,101	Bdnf	0,4	MECP2	Bdnf	4204	627	Gene	Gene	mutations|compound|START_ENTITY caused|nmod|mutations prevents|dep|caused prevents|nsubj|overexpression overexpression|compound|END_ENTITY	Bdnf overexpression in hippocampal neurons prevents dendritic_atrophy caused by Rett-associated MECP2 mutations .
24399845	0	MECP2	30,35	Methyl-CpG-binding_protein_2	0,28	MECP2	Methyl-CpG-binding protein 2	4204	4204	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Methyl-CpG-binding_protein_2 -LRB- MECP2 -RRB- mutation type is associated with disease severity in Rett_syndrome .
23591336	0	MECP2	58,63	methyl-CpG-binding_protein_2	28,56	MECP2	methyl-CpG-binding protein 2	4204	4204	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Mutational analysis of the methyl-CpG-binding_protein_2 -LRB- MECP2 -RRB- gene in male autism patients -RSB- .
22123427	0	MECP2	55,60	methyl-CpG_binding_protein_2	25,53	MECP2	methyl-CpG binding protein 2	4204	4204	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Algorithmic approach for methyl-CpG_binding_protein_2 -LRB- MECP2 -RRB- gene testing in patients with neurodevelopmental_disabilities .
23400946	0	MECP2	53,58	methyl-CpG_binding_protein_2	23,51	MECP2	methyl-CpG binding protein 2	4204	4204	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of methyl-CpG_binding_protein_2 -LRB- MECP2 -RRB- gene in Indian cases of Rett_syndrome .
11267993	0	MED1	8,12	MBD4	14,18	MED1	MBD4	5469	8930	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Role of MED1 -LRB- MBD4 -RRB- Gene in DNA repair and human cancer .
10097147	0	MED1	0,4	MLH1	96,100	MED1	MLH1	5469	4292	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MED1 , a novel human methyl-CpG-binding endonuclease , interacts with DNA mismatch repair protein MLH1 .
25644604	0	MED1	13,17	PRDM16	0,6	MED1	PRDM16	5469	63976	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program .
22162340	0	MED13	47,52	THRAP1	54,60	MED13	THRAP1	9969	9969	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An 800 kb deletion at 17q23 .2 including the MED13 -LRB- THRAP1 -RRB- gene , revealed by aCGH in a patient with a SMC 17p .
16239257	0	MED14	0,5	glucocorticoid_receptor	78,101	MED14	glucocorticoid receptor	9282	2908	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid_receptor .
19049968	0	MED19	0,5	RE1_silencing_transcription_factor	58,92	MED19	RE1 silencing transcription factor	219541	5978	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	MED19 and MED26 are synergistic functional targets of the RE1_silencing_transcription_factor in epigenetic silencing of neuronal gene expression .
27033977	0	MED23	9,14	RUNX2	31,36	MED23	RUNX2	70208(Tax:10090)	12393(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development .
19460352	0	MED23	9,14	insulin	21,28	MED23	insulin	9439	3630	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Mediator MED23 links insulin signaling to the adipogenesis transcription cascade .
21110951	0	MED25	18,23	PTOV1	0,5	MED25	PTOV1	81857	53635	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	PTOV1 antagonizes MED25 in RAR transcriptional activation .
21110951	0	MED25	18,23	RAR	27,30	MED25	RAR	81857	5914	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	PTOV1 antagonizes MED25 in RAR transcriptional activation .
8895518	0	MEF	0,3	Elf-1	42,47	MEF	Elf-1	2000	1997	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	MEF , a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties .
15013761	0	MEF	0,3	beta-defensin_2	23,38	MEF	beta-defensin 2	2000	1673	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	MEF up-regulates human beta-defensin_2 expression in epithelial cells .
17167770	0	MEF	53,56	myeloid_Elf-1-like_factor	26,51	MEF	myeloid Elf-1-like factor	56501(Tax:10090)	56501(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The suppressive effect of myeloid_Elf-1-like_factor -LRB- MEF -RRB- in osteogenic differentiation .
1656214	0	MEF-2	62,67	Myogenin	0,8	MEF-2	Myogenin	17260(Tax:10090)	17928(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products .
8449897	0	MEF-2	50,55	myocyte-specific_enhancer-binding_factor	8,48	MEF-2	myocyte-specific enhancer-binding factor	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of myocyte-specific_enhancer-binding_factor -LRB- MEF-2 -RRB- in transcriptional regulation of the alpha-cardiac myosin heavy chain gene .
17172641	0	MEF2	17,21	Cabin1	0,6	MEF2	Cabin1	4205	23523	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase , SUV39H1 .
17101791	0	MEF2	39,43	HDAC9	14,19	MEF2	HDAC9	4205	9734	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of HDAC9 gene expression by MEF2 establishes a negative-feedback loop in the transcriptional circuitry of muscle differentiation .
15082771	0	MEF2	42,46	HRC	0,3	MEF2	HRC	17260(Tax:10090)	15464(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	HRC is a direct transcriptional target of MEF2 during cardiac , skeletal , and arterial smooth muscle development in vivo .
26455966	0	MEF2	96,100	Macrophage_migration_inhibitory_factor	0,38	MEF2	Macrophage migration inhibitory factor	17260(Tax:10090)	17319(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes .
22484155	0	MEF2	27,31	Myocyte_enhancer_factor_2	0,25	MEF2	Myocyte enhancer factor 2	4205	4205	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- tethering to muscle selective A-kinase anchoring protein -LRB- mAKAP -RRB- is necessary for myogenic differentiation .
8269842	0	MEF2	15,19	hMEF2D	42,48	MEF2	hMEF2D	4205	4209	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	A fourth human MEF2 transcription factor , hMEF2D , is an early marker of the myogenic lineage .
22484155	0	MEF2	27,31	mAKAP	91,96	MEF2	mAKAP	4205	11640(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- tethering to muscle selective A-kinase anchoring protein -LRB- mAKAP -RRB- is necessary for myogenic differentiation .
8817457	0	MEF2	77,81	myocyte_enhancer_factor-2	50,75	MEF2	myocyte enhancer factor-2	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Early expression of the different isoforms of the myocyte_enhancer_factor-2 -LRB- MEF2 -RRB- protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis .
23137781	0	MEF2	104,108	myocyte_enhancer_factor_2	77,102	MEF2	myocyte enhancer factor 2	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Cross-talk between glycogen_synthase_kinase_3b -LRB- GSK3b -RRB- and p38MAPK regulates myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- activity in skeletal and cardiac muscle .
9753748	0	MEF2	42,46	myocyte_enhancer_factor_2	15,40	MEF2	myocyte enhancer factor 2	4205	4205	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- with a mitogen-activated protein kinase , ERK5/BMK1 .
21278418	0	MEF2	27,31	p300	13,17	MEF2	p300	4205	2033	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly .
18216015	0	MEF2A	43,48	GLUT4_enhancer_factor	0,21	MEF2A	GLUT4 enhancer factor	4205	56731	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GLUT4_enhancer_factor -LRB- GEF -RRB- interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes .
21233771	0	MEF2A	0,5	Glut4	21,26	MEF2A	Glut4	17258(Tax:10090)	20528(Tax:10090)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	MEF2A binding to the Glut4 promoter occurs via an AMPKa2-dependent mechanism .
17046827	0	MEF2A	46,51	Myomaxin	0,8	MEF2A	Myomaxin	17258(Tax:10090)	241431(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein .
16407236	0	MEF2A	48,53	Myospryn	0,8	MEF2A	Myospryn	17258(Tax:10090)	76469(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle , alpha-actinin-interacting , costamere-localized protein .
15890826	0	MEF2C	95,100	BOP	0,3	MEF2C	BOP	17260(Tax:10090)	12180(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	BOP , a regulator of right ventricular heart development , is a direct transcriptional target of MEF2C in the developing heart .
18949272	0	MEF2C	45,50	Myocyte-specific_enhancer_binding_factor_2C	0,43	MEF2C	Myocyte-specific enhancer binding factor 2C	499497(Tax:10116)	499497(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Myocyte-specific_enhancer_binding_factor_2C -LRB- MEF2C -RRB- expression in the dentate gyrus during development and after pilocarpine-induced status_epilepticus : a preliminary report .
11554755	0	MEF2C	30,35	SOX18	0,5	MEF2C	SOX18	17260(Tax:10090)	20672(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SOX18 directly interacts with MEF2C in endothelial cells .
22073279	0	MEF2C	94,99	VEGF	0,4	MEF2C	VEGF	4208	7422	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	VEGF promotes the transcription of the human PRL-3 gene in HUVEC through transcription factor MEF2C .
14515274	0	MEF2C	0,5	c-Jun	16,21	MEF2C	c-Jun	17260(Tax:10090)	16476(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells .
20585884	0	MEF2C	77,82	myocyte_enhancer_factor_2C	49,75	MEF2C	myocyte enhancer factor 2C	512254(Tax:9913)	512254(Tax:9913)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Nucleotide sequence and variations of the bovine myocyte_enhancer_factor_2C -LRB- MEF2C -RRB- gene promoter in Bos_taurus cattle .
25472877	0	MEF2D	89,94	miR-122	71,78	MEF2D	miR-122	4209	406906	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Oleanolic_acid suppresses the proliferation of lung_carcinoma cells by miR-122 / Cyclin_G1 / MEF2D axis .
22714905	0	MEF2D	71,76	myocyte_enhancer_factor_2D	43,69	MEF2D	myocyte enhancer factor 2D	100336730	100336730	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of new polymorphisms in the bovine myocyte_enhancer_factor_2D -LRB- MEF2D -RRB- gene on the expression rates of the longissimus dorsi muscle .
22532615	0	MEFV	35,39	Mediterranean_FeVer	9,28	MEFV	Mediterranean FeVer	4210	4210	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Familial Mediterranean_FeVer gene -LRB- MEFV -RRB- mutations as a modifier of systemic_lupus_erythematosus .
17520284	0	MEFV	34,38	Mediterranean_fever	13,32	MEFV	Mediterranean fever	4210	4210	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The familial Mediterranean_fever -LRB- MEFV -RRB- gene may be a modifier factor of inflammatory_bowel_disease in infancy .
23297013	0	MEFV	58,62	Mediterranean_fever	37,56	MEFV	Mediterranean fever	4210	4210	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of missense mutations of Mediterranean_fever -LRB- MEFV -RRB- gene with multiple_sclerosis in Turkish population .
10807793	0	MEFV	43,47	familial_Mediterranean_fever	13,41	MEFV	familial Mediterranean fever	4210	4210	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for familial_Mediterranean_fever , MEFV , is expressed in early leukocyte development and is regulated in response to inflammatory mediators .
14727057	0	MEFV	0,4	familial_Mediterranean_fever	18,46	MEFV	familial Mediterranean fever	4210	4210	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	MEFV mutations in familial_Mediterranean_fever : association of M694V homozygosity with arthritis .
18328141	0	MEFV	0,4	familial_Mediterranean_fever	26,54	MEFV	familial Mediterranean fever	4210	4210	Gene	Gene	analysis|amod|START_ENTITY analysis|nmod|END_ENTITY	MEFV mutation analysis of familial_Mediterranean_fever in Japan .
19784369	0	MEFV	60,64	familial_Mediterranean_fever	25,53	MEFV	familial Mediterranean fever	4210	4210	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variation in the familial_Mediterranean_fever gene -LRB- MEFV -RRB- and risk for Crohn 's _ disease and ulcerative_colitis .
19863562	0	MEFV	0,4	familial_Mediterranean_fever	54,82	MEFV	familial Mediterranean fever	4210	4210	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	MEFV mutations in Iranian Azeri Turkish patients with familial_Mediterranean_fever .
24515776	0	MEG3	19,23	DNA_methyltransferase_1	55,78	MEG3	DNA methyltransferase 1	55384	1786	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	MiR-148a regulates MEG3 in gastric_cancer by targeting DNA_methyltransferase_1 .
26676363	0	MEG3	45,49	DNMT1	62,67	MEG3	DNMT1	55384	1786	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas .
24515776	0	MEG3	19,23	MiR-148a	0,8	MEG3	MiR-148a	55384	406940	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MiR-148a regulates MEG3 in gastric_cancer by targeting DNA_methyltransferase_1 .
26090403	0	MEG3	23,27	VEGF	75,79	MEG3	VEGF	55384	7422	Gene	Gene	Associated|nsubj|START_ENTITY Associated|nmod|Levels Levels|compound|END_ENTITY	The Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis .
12732210	0	MEIS1	7,12	PREP1	0,5	MEIS1	PREP1	4211	5316	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	PREP1 , MEIS1 homolog protein , regulates PF4 gene expression .
18941885	0	MEISETZ	46,53	PRDM9	39,44	MEISETZ	PRDM9	56979	56979	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Two single nucleotide polymorphisms in PRDM9 -LRB- MEISETZ -RRB- gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic_arrest .
19168450	0	MEISETZ	46,53	PRDM9	39,44	MEISETZ	PRDM9	56979	56979	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single-nucleotide polymorphisms of the PRDM9 -LRB- MEISETZ -RRB- gene in patients with nonobstructive azoospermia .
25779166	0	MEK	0,3	CDK4	6,10	MEK	CDK4	5609	1019	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nsubj|+	MEK + CDK4 a regimen for non-BRAF V6000 melanoma .
21040761	0	MEK	11,14	Cyclin-D1	95,104	MEK	Cyclin-D1	5609	595	Gene	Gene	Effects|nmod|START_ENTITY inhibitors|nsubj|Effects inhibitors|nmod|END_ENTITY	Effects of MEK and DNMT inhibitors on arsenic-treated human uroepithelial cells in relation to Cyclin-D1 and p16 .
26251290	0	MEK	62,65	EGFR	71,75	MEK	EGFR	5609	1956	Gene	Gene	INHIBITION|compound|START_ENTITY INHIBITION|compound|END_ENTITY	A MULTICENTER , OPEN-LABEL PHASE II CLINICAL TRIAL OF COMBINED MEK PLUS EGFR INHIBITION FOR CHEMOTHERAPY-REFRACTORY ADVANCED PANCREATIC ADENOCARCINOMA .
21453480	0	MEK	164,167	ERK	208,211	MEK	ERK	5609	5594	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
25774218	0	MEK	176,179	ERK	220,223	MEK	ERK	5609	5594	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Erratum to : Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
16210650	0	MEK	15,18	IL-4	0,4	MEK	IL-4	5609	3565	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-4 regulates MEK expression required for lysophosphatidic_acid-mediated chemokine generation by human mast cells .
19018267	0	MEK	69,72	KRAS	0,4	MEK	KRAS	5609	3845	Gene	Gene	inhibition_in_ovarian_cancer|compound|START_ENTITY sensitivity|nmod|inhibition_in_ovarian_cancer predictor|nmod|sensitivity predictor|nsubj|END_ENTITY	KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition_in_ovarian_cancer .
19401449	0	MEK	47,50	KRAS	65,69	MEK	KRAS	5609	3845	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|cancers cancers|compound|END_ENTITY	PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers .
20358631	0	MEK	63,66	KRAS	0,4	MEK	KRAS	5609	3845	Gene	Gene	activation|compound|START_ENTITY responsive|nmod|activation END_ENTITY|acl:relcl|responsive	KRAS mutant lung_cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation : implication for combinatorial approach .
22082529	0	MEK	98,101	KRAS	116,120	MEK	KRAS	5609	3845	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|cells cells|compound|END_ENTITY	Down-regulation of mitogen-inducible_gene_6 , a negative regulator of EGFR , enhances resistance to MEK inhibition in KRAS mutant cancer cells .
23934108	0	MEK	13,16	KRAS	58,62	MEK	KRAS	5609	3845	Gene	Gene	inhibition|compound|START_ENTITY Mechanism|nmod|inhibition determines|nsubj|Mechanism determines|dobj|efficacy efficacy|nmod|END_ENTITY	Mechanism of MEK inhibition determines efficacy in mutant KRAS - versus BRAF-driven cancers .
24685132	0	MEK	24,27	KRAS	42,46	MEK	KRAS	5609	3845	Gene	Gene	inhibition|compound|START_ENTITY resistance|nmod|inhibition END_ENTITY|nsubj|resistance	Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon_cancer through transcriptional induction of ERBB3 .
24746704	0	MEK	28,31	KRAS	87,91	MEK	KRAS	5609	3845	Gene	Gene	activation|compound|START_ENTITY Disruption|nmod|activation required|nsubjpass|Disruption required|nmod|inhibition inhibition|nmod|tumors tumors|compound|END_ENTITY	Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors .
24746704	0	MEK	69,72	KRAS	87,91	MEK	KRAS	5609	3845	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|tumors tumors|compound|END_ENTITY	Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors .
24931611	0	MEK	62,65	KRAS	80,84	MEK	KRAS	5609	3845	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal_cancer .
25167228	0	MEK	107,110	KRAS	0,4	MEK	KRAS	5609	3845	Gene	Gene	inhibition|compound|START_ENTITY predict|nmod|inhibition predict|nsubj|subtype subtype|compound|END_ENTITY	KRAS mutational subtype and copy number predict in vitro response of human pancreatic_cancer cell lines to MEK inhibition .
25199829	0	MEK	32,35	KRAS	50,54	MEK	KRAS	5609	3845	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|cells cells|compound|END_ENTITY	RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells .
25326806	0	MEK	8,11	KRAS	89,93	MEK	KRAS	17242(Tax:10090)	16653(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|effect effect|nmod|END_ENTITY	Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF_and_matrix_metallopeptidase-9 .
26075998	0	MEK	12,15	KRAS	86,90	MEK	KRAS	5609	3845	Gene	Gene	Response|nmod|START_ENTITY inhibitor|nsubj|Response inhibitor|nmod|small_cell_neuroendocrine_carcinoma small_cell_neuroendocrine_carcinoma|nmod|cervix cervix|nmod|mutation mutation|compound|END_ENTITY	Response to MEK inhibitor in small_cell_neuroendocrine_carcinoma of the cervix with a KRAS mutation .
26404261	0	MEK	19,22	KRAS	43,47	MEK	KRAS	5609	3845	Gene	Gene	Pathway|compound|START_ENTITY Inhibition|nmod|Pathway Inhibition|nmod|END_ENTITY	Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal_Cancers .
21441910	0	MEK	73,76	KSR	39,42	ERK	KSR	5594	8844	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|transition transition|nmod|END_ENTITY	A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK .
21451123	0	MEK	2,5	Kras	56,60	MEK	Kras	17242(Tax:10090)	16653(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY abrogates|nsubj|inhibitor abrogates|dobj|disease disease|nmod|mice mice|compound|END_ENTITY	A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice .
21632463	0	MEK	43,46	Kras	63,67	MEK	Kras	17242(Tax:10090)	16653(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras -LRB- G12D -RRB- ; Pten deletion mouse model of ovarian_cancer .
9427625	0	MEK	26,29	Ksr	7,10	MEK	Ksr	17242(Tax:10090)	16706(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Murine Ksr interacts with MEK and inhibits Ras-induced transformation .
9427629	0	MEK	86,89	Ksr	50,53	MEK	Ksr	5609	8844	Gene	Gene	interaction|nmod|START_ENTITY kinase|nmod|interaction kinase|nmod|END_ENTITY	Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK .
8690082	0	MEK	33,36	MAP_kinase_kinase	14,31	MEK	MAP kinase kinase	5609	5609	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of MAP_kinase_kinase -LRB- MEK -RRB- blocks endothelial PGI2 release but has no effect on von_Willebrand factor secretion or E-selectin expression .
21705440	0	MEK	105,108	MEK1	22,26	MEK	MEK1	5609	5604	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the MEK1 -LRB- F129L -RRB- activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation .
15930308	0	MEK	34,37	RAF	28,31	MEK	RAF	5609	22882	Gene	Gene	inhibition|dep|START_ENTITY inhibition|nmod|END_ENTITY	Pharmacologic inhibition of RAF -- > MEK -- > ERK signaling elicits pancreatic_cancer cell cycle arrest through induced expression of p27Kip1 .
24849047	0	MEK	31,34	RAF	52,55	MEK	RAF	5609	22882	Gene	Gene	independently|compound|START_ENTITY independently|nmod|END_ENTITY	Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors .
21444672	0	MEK	29,32	STAT3	0,5	MEK	STAT3	5609	6774	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	STAT3 mediates resistance to MEK inhibitor through microRNA miR-17 .
10350046	0	MEK	0,3	Stat5b	31,37	MEK	Stat5b	5609	6777	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MEK is a negative regulator of Stat5b in PDGF-stimulated cells .
12730674	0	MEK	21,24	c-Raf-1	13,20	MEK	c-Raf-1	5609	7187	Gene	Gene	cascade|compound|START_ENTITY cascade|amod|END_ENTITY	Integrity of c-Raf-1 / MEK signal transduction cascade is essential for hepatitis_B virus gene expression .
9528964	0	MEK	41,44	insulin-like_growth_factor_1	120,148	MEK	insulin-like growth factor 1	5609	3479	Gene	Gene	required|dep|START_ENTITY required|nmod|END_ENTITY	Mitogen-activated protein kinase kinase -LRB- MEK -RRB- activity is required for inhibition of skeletal muscle differentiation by insulin-like_growth_factor_1 or fibroblast_growth_factor_2 .
16432158	0	MEK	180,183	interleukin-6_receptor	91,113	MEK	interleukin-6 receptor	5609	3570	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6_receptor and epidermal_growth_factor_receptor signaling through JAK and/or MEK in head_and_neck_squamous_cell_carcinomas .
15069060	0	MEK	0,3	interleukin-8	40,53	MEK	interleukin-8	5609	3576	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|END_ENTITY	MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells .
24706368	0	MEK	81,84	mitogen-activated_protein_kinase_kinase	40,79	MEK	mitogen-activated protein kinase kinase	5609	5609	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	MR-detectable metabolic consequences of mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- inhibition .
7835430	0	MEK-1	68,73	B-Raf	52,57	MEK-1	B-Raf	170851(Tax:10116)	114486(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Regulation of the MAP kinase cascade in PC12 cells : B-Raf activates MEK-1 -LRB- MAP kinase or ERK kinase -RRB- and is inhibited by cAMP .
23360980	0	MEK-1	0,5	C-Raf	16,21	MEK-1	C-Raf	5604	5894	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	MEK-1 activates C-Raf through a Ras-independent mechanism .
8621729	0	MEK1	24,28	A-Raf	45,50	MEK1	A-Raf	5604	369	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Selective activation of MEK1 but not MEK2 by A-Raf from epidermal_growth_factor-stimulated Hela cells .
26208884	0	MEK1	0,4	ERK	31,34	MEK1	ERK	26395(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages .
15020233	0	MEK1	61,65	Glycogen_synthase_kinase-3beta	0,30	MEK1	Glycogen synthase kinase-3beta	5604	2932	Gene	Gene	tyrosine-phosphorylated|nmod|START_ENTITY tyrosine-phosphorylated|nsubjpass|END_ENTITY	Glycogen_synthase_kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts .
11527379	0	MEK1	68,72	IL-1beta	27,35	MEK1	IL-1beta	26395(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral_ischemia in mice .
10623478	0	MEK1	46,50	MAP_kinase_kinase	27,44	MEK1	MAP kinase kinase	26395(Tax:10090)	26395(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Constitutive activation of MAP_kinase_kinase -LRB- MEK1 -RRB- is critical and sufficient for the activation of MMP-2 .
21705440	0	MEK1	22,26	MEK	105,108	MEK1	MEK	5604	5609	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the MEK1 -LRB- F129L -RRB- activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation .
7624324	0	MEK1	21,25	MEKK1	0,5	MEK1	MEKK1	5604	4214	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase .
23241949	0	MEK1	0,4	Myt1	17,21	MEK1	Myt1	5604	4661	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells .
12876277	0	MEK1	24,28	PAK1	0,4	MEK1	PAK1	5604	5058	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation .
22723831	0	MEK1	0,4	PPARa	22,27	MEK1	PPARa	26395(Tax:10090)	19013(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	MEK1 inhibits cardiac PPARa activity by direct interaction and prevents its nuclear localization .
23453810	0	MEK1	0,4	PTEN	21,25	MEK1	PI3K	5604	5293	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|recruitment recruitment|compound|END_ENTITY	MEK1 is required for PTEN membrane recruitment , AKT regulation , and the maintenance of peripheral tolerance .
18593598	0	MEK1	15,19	WNK2	0,4	MEK1	WNK2	5604	65268	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	WNK2 modulates MEK1 activity through the Rho GTPase pathway .
23217386	0	MEK1	0,4	insulin	44,51	MEK1	insulin	5604	3630	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	MEK1 and MEK2 differentially regulate human insulin - _ and_insulin glargine-induced human bladder_cancer T24 cell proliferation .
10465442	0	MEK1	89,93	mitogen-activated_protein_kinase_kinase1	47,87	MEK1	mitogen-activated protein kinase kinase1	170851(Tax:10116)	170851(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The topography and subcellular distribution of mitogen-activated_protein_kinase_kinase1 -LRB- MEK1 -RRB- in adult rat brain and differentiating PC12 cells .
26242183	0	MEK1/2	15,21	Plk1	0,4	MEK1/2	Plk1	5604;5605	5347	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells .
26242183	0	MEK1/2	15,21	Plk1	0,4	MEK1/2	Plk1	5604;5605	5347	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells .
24819614	0	MEK1_and_2	58,68	mitogen-activated_protein_kinase_kinase_1_and_2	9,56	MEK1 and 2	mitogen-activated protein kinase kinase 1 and 2	5604;5605	5604;5605	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	U0126 , a mitogen-activated_protein_kinase_kinase_1_and_2 -LRB- MEK1_and_2 -RRB- inhibitor , selectively up-regulates main isoforms of CYP3A subfamily via a pregnane_X_receptor -LRB- PXR -RRB- in HepG2 cells .
12608905	0	MEK2	132,136	Basic_fibroblast_growth_factor	0,30	MEK2	Basic fibroblast growth factor	5605	2247	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces the expression of matrix_metalloproteinase-3 in human periodontal ligament cells through the MEK2 mitogen-activated protein kinase pathway .
9733728	0	MEK3	84,88	involucrin	20,30	MEK3	involucrin	5606	3713	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of human involucrin promoter activity by a protein kinase C , Ras , MEKK1 , MEK3 , p38/RK , AP1 signal transduction pathway .
12912994	0	MEK5	49,53	PB1	54,57	MEK5	PB1	5607	26952	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway .
10593883	0	MEK5	25,29	mitogen-activated_protein_kinase_1	58,92	MEK5	mitogen-activated protein kinase 1	5607	5594	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated_protein_kinase_1 -LRB- BMK1 -RRB- signaling pathway .
11454875	0	MEK6	0,4	involucrin	21,31	MEK6	involucrin	5608	3713	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MEK6 regulates human involucrin gene expression via a p38alpha - and p38delta - dependent mechanism .
17078934	0	MEKK-1	25,31	JNK	32,35	MEKK-1	JNK	4214	5599	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Divergent effects of the MEKK-1 / JNK pathway on NB2a/d1 differentiation : some activity is required for outgrowth and stabilization of neurites but overactivation inhibits both phenomena .
14734742	0	MEKK-2	41,47	c-Jun_N-terminal_kinase	14,37	MEKK-2	c-Jun N-terminal kinase	10746	5599	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Regulation of c-Jun_N-terminal_kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid_arthritis .
24277696	0	MEKK1	91,96	CXCL8	70,75	MEKK1	CXCL8	4214	3576	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Thrombin-induced CCAAT/enhancer-binding protein b activation and IL-8 / CXCL8 expression via MEKK1 , ERK , and p90 ribosomal S6 kinase 1 in lung epithelial cells .
16427076	0	MEKK1	31,36	Caspase-3	0,9	MEKK1	Caspase-3	4214	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity .
16006144	0	MEKK1	0,5	ERK1/2	71,77	MEKK1	ERK1/2	116667(Tax:10116)	50689;116590	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling .
9689078	0	MEKK1	0,5	IkappaB_kinase_alpha	21,41	MEKK1	IkappaB kinase alpha	4214	1147	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	MEKK1 activates both IkappaB_kinase_alpha and IkappaB_kinase_beta .
19710465	0	MEKK1	0,5	Itch	27,31	MEKK1	Itch	4214	83737	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression .
7624324	0	MEKK1	0,5	MEK1	21,25	MEKK1	MEK1	4214	5604	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase .
10196170	0	MEKK1	42,47	MEK_kinase_1	28,40	MEKK1	MEK kinase 1	4214	4214	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Differential involvement of MEK_kinase_1 -LRB- MEKK1 -RRB- in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents .
17023433	0	MEKK1	0,5	MPK4	22,26	MEKK1	MPK4	826409(Tax:3702)	828151(Tax:3702)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis .
17142480	0	MEKK1	0,5	MPK4	36,40	MEKK1	MPK4	826409(Tax:3702)	828151(Tax:3702)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants .
7997270	0	MEKK1	49,54	SEK1	88,92	MEKK1	SEK1	4214	6416	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 .
14612408	0	MEKK1	62,67	TR3	36,39	MEKK1	TR3	4214	3164	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung_cancer cells .
10401575	0	MEKK1	0,5	alpha-actinin	21,34	MEKK1	alpha-actinin	4214	87	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions .
11075819	0	MEKK1	0,5	estrogen_receptor_alpha	26,49	MEKK1	estrogen receptor alpha	4214	2099	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	MEKK1 activation of human estrogen_receptor_alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial_and_ovarian_cancer cells .
15159407	0	MEKK1	0,5	p38	24,27	MEKK1	p38	4214	1432	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis .
17906693	0	MEKK1/2	23,30	serine-threonine_kinase_38	44,70	MEKK1/2	serine-threonine kinase 38	4214;10746	11329	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of MEKK1/2 signaling by serine-threonine_kinase_38 -LRB- STK38 -RRB- .
14978743	0	MEKK2	0,5	ERK5	45,49	MEKK2	ERK5	26405(Tax:10090)	23939(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts .
14978743	0	MEKK2	0,5	FGF-2	73,78	MEKK2	FGF-2	26405(Tax:10090)	14173(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts .
11278622	0	MEKK2	0,5	JNK	49,52	MEKK2	JNK	10746	5599	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression .
21471448	0	MEKK3	0,5	IFN-gamma	16,25	MEKK3	IFN-gamma	26406(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades .
11429546	0	MEKK3	22,27	NF-kappaB	43,52	MEKK3	NF-kappaB	4215	4790	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	The essential role of MEKK3 in TNF-induced NF-kappaB activation .
19289495	0	MEKK4	73,78	Jun_N-terminal_kinase	93,114	MEKK4	Jun N-terminal kinase	26407(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Trophoblast stem cell maintenance by fibroblast_growth_factor_4 requires MEKK4 activation of Jun_N-terminal_kinase .
18775659	0	MEKK4	0,5	RIP2	17,21	MEKK4	RIP2	4216	8767	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	MEKK4 sequesters RIP2 to dictate NOD2 signal specificity .
15731347	0	MEKK4	58,63	mitogen-activated_protein_kinase_kinase_kinase_4	8,56	MEKK4	mitogen-activated protein kinase kinase kinase 4	4216	4216	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Loss of mitogen-activated_protein_kinase_kinase_kinase_4 -LRB- MEKK4 -RRB- results in enhanced apoptosis and defective_neural_tube development .
10196170	0	MEK_kinase_1	28,40	MEKK1	42,47	MEK kinase 1	MEKK1	4214	4214	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Differential involvement of MEK_kinase_1 -LRB- MEKK1 -RRB- in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents .
16044153	0	MEK_kinase_1	0,12	STAT3	46,51	MEK kinase 1	STAT3	4214	6774	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	MEK_kinase_1 is essential for Bcr-Abl-induced STAT3 and self-renewal activity in embryonic_stem cells .
14627958	0	MEK_kinase_1	0,12	c-Jun	23,28	MEK kinase 1	c-Jun	26401(Tax:10090)	16476(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	MEK_kinase_1 regulates c-Jun phosphorylation in the control of corneal morphogenesis .
10805784	0	MEK_kinase_1	0,12	c-Jun_N-terminal_kinase	40,63	MEK kinase 1	c-Jun N-terminal kinase	4214	5599	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	MEK_kinase_1 is critically required for c-Jun_N-terminal_kinase activation by proinflammatory stimuli and growth factor-induced cell migration .
12458213	0	MEK_kinase_1	0,12	focal_adhesion_kinase	28,49	MEK kinase 1	focal adhesion kinase	26401(Tax:10090)	14083(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MEK_kinase_1 interacts with focal_adhesion_kinase and regulates insulin_receptor_substrate-1 expression .
12640115	0	MEK_kinase_2	0,12	epidermal_growth_factor	104,127	MEK kinase 2	epidermal growth factor	10746	1950	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	MEK_kinase_2 and the adaptor protein Lad regulate extracellular_signal-regulated_kinase_5 activation by epidermal_growth_factor via Src .
10818102	0	MEK_kinase_2	0,12	protein_kinase_C-related_kinase_2	33,66	MEK kinase 2	protein kinase C-related kinase 2	10746	5586	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	MEK_kinase_2 binds and activates protein_kinase_C-related_kinase_2 .
9162092	1	MEK_kinase_3	157,169	MKK3	180,184	MEK kinase 3	MKK3	4215	5606	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	MEK_kinase_3 activates MKK3 but does not cause activation of p38 kinase in vivo .
18211895	0	MEL-18	0,6	HSF2	22,26	MEL-18	HSF2	7703	3298	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation .
18211895	0	MEL-18	0,6	HSF2	59,63	MEL-18	HSF2	7703	3298	Gene	Gene	interacts|nsubj|START_ENTITY interacts|xcomp|inhibit inhibit|dobj|sumoylation sumoylation|compound|END_ENTITY	MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation .
17403899	0	MEL-26	104,110	CIF-1	0,5	MEL-26	CIF-1	172737(Tax:6239)	177236(Tax:6239)	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	CIF-1 , a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes , regulates MEL-26 levels in the Caenorhabditis_elegans embryo .
22621901	0	MEL-26	27,33	UNC-89	0,6	MEL-26	UNC-89	172737(Tax:6239)	171990(Tax:6239)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	UNC-89 -LRB- obscurin -RRB- binds to MEL-26 , a BTB-domain protein , and affects the function of MEI-1 -LRB- katanin -RRB- in striated muscle of Caenorhabditis_elegans .
24167714	0	MELK	37,41	RACK1	62,67	MELK	RACK1	397927(Tax:8355)	495666(Tax:8355)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme-like cells in Xenopus embryo .
25365263	0	MELK	66,70	maternal_embryonic_leucine-zipper_kinase	24,64	MELK	maternal embryonic leucine-zipper kinase	9833	9833	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Preclinical efficacy of maternal_embryonic_leucine-zipper_kinase -LRB- MELK -RRB- inhibition in acute_myeloid_leukemia .
9922473	0	MEN-1	88,93	multiple_endocrine_neoplasia_type-1	51,86	MEN-1	multiple endocrine neoplasia type-1	4221	4221	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Molecular diagnosis in an Argentinian family with multiple_endocrine_neoplasia_type-1 -LRB- MEN-1 -RRB- -RSB- .
7587389	0	MEN1	45,49	Plcb3	90,95	MEN1	Plcb3	4221	5331	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the mouse homologue of a human MEN1 candidate gene , phospholipase_C-beta_3 -LRB- Plcb3 -RRB- , to chromosome region 19B by FISH .
17135306	0	MEN1	24,28	gastrin	46,53	MEN1	gastrin	4221	2520	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions .
10576763	0	MEN1	9,13	multiple_endocrine_neoplasia_type_1	58,93	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	mutations|nsubj|START_ENTITY mutations|nmod|END_ENTITY	Germline MEN1 mutations in sixteen Japanese families with multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- .
10715991	0	MEN1	62,66	multiple_endocrine_neoplasia_type_1	25,60	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Somatic mutations of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene in patients with sporadic , nonfamilial primary_hyperparathyroidism .
12941803	0	MEN1	83,87	multiple_endocrine_neoplasia_type_1	46,81	MEN1	multiple endocrine neoplasia type 1	17283(Tax:10090)	17283(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pancreatic beta-cell-specific ablation of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene causes full penetrance of insulinoma development in mice .
15240620	0	MEN1	47,51	multiple_endocrine_neoplasia_type_1	10,45	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effect of multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene mutations on premature mortality in familial_MEN1_syndrome with founder mutations .
17188139	0	MEN1	96,100	multiple_endocrine_neoplasia_type_1	59,94	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Recognizing genes differentially regulated in vitro by the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene , using RNA interference and oligonucleotide microarrays .
17953629	0	MEN1	0,4	multiple_endocrine_neoplasia_type_1	47,82	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	MEN1 gene mutations in Hungarian patients with multiple_endocrine_neoplasia_type_1 .
9067266	0	MEN1	91,95	multiple_endocrine_neoplasia_type_1	54,89	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotype analysis defines a minimal interval for the multiple_endocrine_neoplasia_type_1 _ -LRB- MEN1 -RRB- _ gene .
9205115	0	MEN1	66,70	multiple_endocrine_neoplasia_type_1	29,64	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	A 2.8-Mb clone contig of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- region at 11q13 .
9215690	0	MEN1	59,63	multiple_endocrine_neoplasia_type_1	22,57	MEN1	multiple endocrine neoplasia type 1	539431(Tax:9913)	539431(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene .
9286704	0	MEN1	121,125	multiple_endocrine_neoplasia_type_1	84,119	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene .
9385379	0	MEN1	77,81	multiple_endocrine_neoplasia_type_1	40,75	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Eighteen new polymorphic markers in the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- region .
9506756	0	MEN1	75,79	multiple_endocrine_neoplasia_type_1	38,73	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Absence of germ-line mutations of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene in familial_pituitary_adenoma in contrast to MEN1 in Japanese .
9747036	0	MEN1	6,10	multiple_endocrine_neoplasia_type_1	38,73	MEN1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Novel MEN1 gene mutations in familial multiple_endocrine_neoplasia_type_1 .
9157974	0	MEN1	57,61	multiple_endocrine_neoplasia_type_I	20,55	MEN1	multiple endocrine neoplasia type I	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the multiple_endocrine_neoplasia_type_I -LRB- MEN1 -RRB- gene based on tumor loss of heterozygosity analysis .
12210500	0	MEN1	73,77	multiple_endocrine_neoplasm_type_1	37,71	MEN1	multiple endocrine neoplasm type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Determination of allelic deletion of multiple_endocrine_neoplasm_type_1 -LRB- MEN1 -RRB- gene in acute_myeloid_leukemia -LRB- AML -RRB- by application of FISH-TSA technique .
7824936	0	MEN2A	75,80	RET	14,17	MEN2A	RET	5979	5979	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B .
8570194	0	MEN2A	27,32	RET	0,3	MEN2A	RET	5979	5979	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	RET activation by germline MEN2A and MEN2B mutations .
17923033	0	MEN2A	94,99	multiple_endocrine_neoplasia_type_2A	56,92	MEN2A	multiple endocrine neoplasia type 2A	5979	5979	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- DelD631 : a novel mutation of the RET proto-oncogene in multiple_endocrine_neoplasia_type_2A -LRB- MEN2A -RRB- -RSB- .
11446674	0	MEN_1	75,80	multiple_endocrine_neoplasia_type_1	38,73	MEN 1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A germline mutation , 1001delC , of the multiple_endocrine_neoplasia_type_1 -LRB- MEN_1 -RRB- gene in a Japanese family .
9003511	0	MEN_1	146,151	multiple_endocrine_neoplasia_type_1	109,144	MEN 1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 -LRB- PLC_beta_3 -RRB- gene as candidate for the multiple_endocrine_neoplasia_type_1 -LRB- MEN_1 -RRB- gene .
9066984	0	MEN_1	112,117	multiple_endocrine_neoplasia_type_1	75,110	MEN 1	multiple endocrine neoplasia type 1	4221	4221	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exclusion of the nuclear_factor-kappa_B3 -LRB- REL_A -RRB- gene as candidate for the multiple_endocrine_neoplasia_type_1 -LRB- MEN_1 -RRB- gene .
7915165	0	MEN_2A	26,32	RET	9,12	MEN 2A	RET	5979	5979	Gene	Gene	mutations|nmod|START_ENTITY mutations|nsubj|END_ENTITY	Germline RET mutations in MEN_2A and FMTC and their detection by simple DNA diagnostic tests .
19340300	0	MEOX2	53,58	INK4a	93,98	MEOX2	INK4a	4223	1029	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a .
16712789	0	MEP50	59,64	SUZ12	30,35	MEP50	SUZ12	79084	23512	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro .
15664000	0	MEPE	46,50	PHEX	60,64	MEPE	PHEX	94111(Tax:10090)	18675(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Surface plasmon resonance -LRB- SPR -RRB- confirms that MEPE binds to PHEX via the MEPE-ASARM motif : a model for impaired_mineralization in X-linked_rickets -LRB- HYP -RRB- .
22339660	0	MEPE	79,83	PHEX	60,64	MEPE	PHEX	56955	5251	Gene	Gene	ASARM|appos|START_ENTITY END_ENTITY|appos|ASARM	Regulation of bone-renal mineral and energy metabolism : the PHEX , FGF23 , DMP1 , MEPE ASARM pathway .
12220505	0	MEPE	14,18	Phex	31,35	MEPE	Phex	94111(Tax:10090)	18675(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY cleavage|nsubj|Inhibition cleavage|nmod|END_ENTITY	Inhibition of MEPE cleavage by Phex .
21248358	0	MEPE	0,4	furin	18,23	MEPE	furin	56955	5045	Gene	Gene	START_ENTITY|acl|activated activated|nmod|END_ENTITY	MEPE activated by furin promotes pulpal cell adhesion .
26338419	0	MERIT40	0,7	BRCA2	24,29	MERIT40	BRCA2	68251(Tax:10090)	12190(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links .
15380065	0	MES-2	4,9	MES-6	16,21	MES-2	MES-6	175096(Tax:6239)	177657(Tax:6239)	Gene	Gene	START_ENTITY|amod|complex complex|amod|END_ENTITY	The MES-2 / MES-3 / MES-6 complex and regulation of histone H3 methylation in C. _ elegans .
15380065	0	MES-6	16,21	MES-2	4,9	MES-6	MES-2	177657(Tax:6239)	175096(Tax:6239)	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	The MES-2 / MES-3 / MES-6 complex and regulation of histone H3 methylation in C. _ elegans .
1789010	0	MET3	18,22	TDH2	0,4	MET3	TDH2	853466(Tax:4932)	853465(Tax:4932)	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	TDH2 is linked to MET3 on chromosome X of Saccharomyces_cerevisiae .
24501276	0	METTL23	0,7	GABPA	38,43	METTL23	GABPA	124512	2551	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	METTL23 , a transcriptional partner of GABPA , is essential for human cognition .
23408853	0	MEX3A	43,48	CDX2	0,4	MEX3A	CDX2	72640(Tax:10090)	12591(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	CDX2 regulation by the RNA-binding protein MEX3A : impact on intestinal differentiation and stemness .
18322703	0	MFAP4	84,89	microfibril-associated_glycoprotein	39,74	MFAP4	microfibril-associated glycoprotein	287382(Tax:10116)	287382(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential gene expression of 36-kDa microfibril-associated_glycoprotein -LRB- MAGP-36 / MFAP4 -RRB- in rat organs .
26899386	0	MFAP4	49,54	microfibrillar-associated_protein_4	12,47	MFAP4	microfibrillar-associated protein 4	76293(Tax:10090)	76293(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of microfibrillar-associated_protein_4 -LRB- MFAP4 -RRB- in the formation and function of splenic compartments during embryonic and adult life .
18392683	0	MFG-E8	18,24	Prolactin	0,9	MFG-E8	Prolactin	4240	5617	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Prolactin induces MFG-E8 production in macrophages via transcription factor C/EBPbeta-dependent pathway .
17638889	0	MFG-E8	0,6	lactadherin	7,18	MFG-E8	lactadherin	17304(Tax:10090)	17304(Tax:10090)	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	MFG-E8 / lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis .
21841820	0	MFG-E8	0,6	lactadherin	7,18	MFG-E8	lactadherin	17304(Tax:10090)	17304(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	MFG-E8 / lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells .
20213738	0	MFG-E8	56,62	milk_fat_globule-EGF_factor_8	25,54	MFG-E8	milk fat globule-EGF factor 8	4240	4240	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aberrant splicing of the milk_fat_globule-EGF_factor_8 -LRB- MFG-E8 -RRB- gene in human systemic_lupus_erythematosus .
23454767	0	MFGE8	0,5	IL-1b	36,41	MFGE8	IL-1b	17304(Tax:10090)	16176(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	MFGE8 inhibits inflammasome-induced IL-1b production and limits postischemic_cerebral_injury .
20661427	0	MFN1	100,104	IPS-1	82,87	MFN1	IPS-1	55669	57506	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Virus-infection or 5 ` ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1 .
24876927	0	MFN2	29,33	MNS1	80,84	MFN2	MNS1	170731(Tax:10090)	17427(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mitochondrial fusion protein MFN2 interacts with the mitostatin-related protein MNS1 required for mouse sperm flagellar structure and function .
16762064	0	MFN2	81,85	mitofusin_2	63,74	MFN2	mitofusin 2	9927	9927	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Charcot-Marie-Tooth_neuropathy type 2A : novel mutations in the mitofusin_2 gene -LRB- MFN2 -RRB- .
20951042	0	MFN2	77,81	mitofusin_2	59,70	MFN2	mitofusin 2	567448(Tax:7955)	567448(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Developmental_defects_and_neuromuscular_alterations due to mitofusin_2 gene -LRB- MFN2 -RRB- silencing in zebrafish : a new model for Charcot-Marie-Tooth_type_2A_neuropathy .
21526202	0	MFN2	50,54	mitofusin_2	32,43	MFN2	mitofusin 2	534574(Tax:9913)	534574(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An unusual splice defect in the mitofusin_2 gene -LRB- MFN2 -RRB- is associated with degenerative_axonopathy in Tyrolean Grey cattle .
10488241	0	MFP1	86,90	MAF1	0,4	MFP1	MAF1	544122(Tax:4081)	543586(Tax:4081)	Gene	Gene	interacting|nmod|START_ENTITY protein|acl|interacting END_ENTITY|appos|protein	MAF1 , a novel plant protein interacting with matrix attachment region binding protein MFP1 , is located at the nuclear envelope .
17122143	0	MFRP	35,39	CTRP5	65,70	MFRP	CTRP5	259172(Tax:10090)	235312(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Spatial and temporal expression of MFRP and its interaction with CTRP5 .
16352475	0	MFRP	63,67	membrane-type_frizzled-related_protein	23,61	MFRP	membrane-type frizzled-related protein	83552	83552	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation screen of the membrane-type_frizzled-related_protein -LRB- MFRP -RRB- gene in patients with inherited_retinal_degenerations .
18781223	0	MFRP	54,58	membrane_frizzled-related_protein	19,52	MFRP	membrane frizzled-related protein	83552	83552	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association of membrane_frizzled-related_protein -LRB- MFRP -RRB- gene with acute_angle-closure_glaucoma -- a pilot study .
23177091	0	MFSD2a	0,6	Syncytin-2	12,22	MFSD2a	Syncytin-2	84879	405754	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	MFSD2a , the Syncytin-2 receptor , is important for trophoblast fusion .
23551903	0	MG-132	21,27	MCPIP1	36,42	MG-132	MCPIP1	875581(Tax:243273)	80149	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Proteasome inhibitor MG-132 induces MCPIP1 expression .
24992982	0	MG-132	59,65	MCPIP1	0,6	MG-132	MCPIP1	875581(Tax:243273)	80149	Gene	Gene	toxicity|nmod|START_ENTITY contributes|nmod|toxicity contributes|nsubj|END_ENTITY	MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-kB .
12067409	0	MG-132	21,27	interleukin-6	55,68	MG-132	interleukin-6	875581(Tax:243273)	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Proteasome inhibitor MG-132 enhances the expression of interleukin-6 in human umbilical vein endothelial cells : Involvement of MAP/ERK kinase .
7768993	0	MG-160	0,6	basic_fibroblast_growth_factor	95,125	MG-160	basic fibroblast growth factor	875275(Tax:243273)	54250(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	MG-160 , a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus , binds basic_fibroblast_growth_factor and exhibits a high level of sequence identity to a chicken fibroblast growth factor receptor .
2595297	0	MG111	17,22	hEGF	11,15	MG111	hEGF	875452(Tax:243273)	1950	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of hEGF -LRB- MG111 -RRB- on gastric mucosal potential difference in rats .
19006120	0	MG132	21,26	BAG3	35,39	MG132	BAG3	875581(Tax:243273)	9531	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Proteasome inhibitor MG132 induces BAG3 expression through activation of heat_shock factor 1 .
21811429	0	MG132	60,65	DR5	21,24	MG132	DR5	875581(Tax:243273)	8795	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of the DR5 expression by proteasome inhibitor MG132 augments TRAIL-induced apoptosis in soft tissue sarcoma cell lines .
23261467	0	MG132	21,26	GDF15	41,46	MG132	GDF15	875581(Tax:243273)	9518	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Proteasome inhibitor MG132 induces NAG-1 / GDF15 expression through the p38 MAPK pathway in glioblastoma cells .
23261467	0	MG132	21,26	NAG-1	35,40	MG132	NAG-1	875581(Tax:243273)	9518	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Proteasome inhibitor MG132 induces NAG-1 / GDF15 expression through the p38 MAPK pathway in glioblastoma cells .
23430855	0	MG132	69,74	NPC1	40,44	MG132	NPC1	875581(Tax:243273)	4864	Gene	Gene	Mutations|nmod|START_ENTITY Mutations|compound|END_ENTITY	Treatment of Human Fibroblasts Carrying NPC1 Missense Mutations with MG132 Leads to an Improvement of Intracellular Cholesterol Trafficking .
14691451	0	MG132	21,26	death_receptor_5	39,55	MG132	death receptor 5	875581(Tax:243273)	8795	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Proteasome inhibitor MG132 upregulates death_receptor_5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and - deficient cells .
15994939	0	MG132	21,26	death_receptor_5	35,51	MG132	death receptor 5	875581(Tax:243273)	8795	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Proteasome inhibitor MG132 induces death_receptor_5 through CCAAT/enhancer-binding _ protein_homologous_protein .
12868001	0	MG132	86,91	pRb	121,124	MG132	pRb	875581(Tax:243273)	5925	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb .
11172811	0	MG132	25,30	steroidogenic_acute_regulatory_protein	60,98	MG132	steroidogenic acute regulatory protein	875581(Tax:243273)	6770	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|nmod|END_ENTITY	The proteasome inhibitor MG132 promotes accumulation of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- and steroidogenesis .
23904368	0	MG132	33,38	transforming_growth_factor-b	46,74	MG132	transforming growth factor-b	875581(Tax:243273)	7040	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of the protease inhibitor MG132 on the transforming_growth_factor-b / Smad signaling pathway in HSC-T6 cells .
21075079	0	MGA2	11,15	ERG1	66,70	MGA2	ERG1	854851(Tax:4932)	853086(Tax:4932)	Gene	Gene	role|nmod|START_ENTITY role|nmod|transcription transcription|nmod|END_ENTITY	A role for MGA2 , but not SPT23 , in activation of transcription of ERG1 in Saccharomyces_cerevisiae .
22869740	0	MGAT1	71,76	monoacylglycerol_O-acyltransferase_1	33,69	MGAT1	monoacylglycerol O-acyltransferase 1	68393(Tax:10090)	68393(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Nuclear receptor PPARy-regulated monoacylglycerol_O-acyltransferase_1 -LRB- MGAT1 -RRB- expression is responsible for the lipid accumulation in diet-induced hepatic_steatosis .
7822271	0	MGDF	87,91	megakaryocyte_growth_and_development_factor	42,85	MGDF	megakaryocyte growth and development factor	7066	7066	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and characterization of the human megakaryocyte_growth_and_development_factor -LRB- MGDF -RRB- gene .
7514283	0	MGF	110,113	mast_cell_growth_factor	85,108	MGF	mast cell growth factor	4254	4254	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Protein kinase C-dependent release of a functional whole extracellular domain of the mast_cell_growth_factor -LRB- MGF -RRB- receptor by MGF-dependent human myeloid cells .
24075770	0	MGL-3196	68,76	thyroid_hormone_receptor-b	95,121	MGL-3196	thyroid hormone receptor-b	5853958(Tax:425265)	7068	Gene	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196 , a liver-targeted thyroid_hormone_receptor-b agonist .
21405945	0	MGMT	68,72	Akt	50,53	MGMT	Akt	4255	207	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells .
22288845	0	MGMT	58,62	CDKN2A	64,70	MGMT	CDKN2A	4255	1029	Gene	Gene	GSTP1|compound|START_ENTITY GSTP1|appos|END_ENTITY	Identification of promoter region methylation patterns of MGMT , CDKN2A , GSTP1 , and THBS1 genes in intracranial_meningioma patients .
16140920	0	MGMT	58,62	IFN-beta	0,8	MGMT	IFN-beta	4255	3456	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide .
19274096	0	MGMT	12,16	MGMT	66,70	MGMT	MGMT	4255	4255	Gene	Gene	START_ENTITY|nmod|status status|compound|END_ENTITY	Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors .
19274096	0	MGMT	66,70	MGMT	12,16	MGMT	MGMT	4255	4255	Gene	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	Homogeneous MGMT immunoreactivity correlates with an unmethylated MGMT promoter status in brain metastases of various solid tumors .
9653449	0	MGMT	101,105	MGMT	87,91	MGMT	MGMT	4255	4255	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
9653449	0	MGMT	87,91	MGMT	101,105	MGMT	MGMT	4255	4255	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
1832990	0	MGMT	53,57	O-6_methylguanine_DNA_methyltransferase	12,51	MGMT	O-6 methylguanine DNA methyltransferase	4255	4255	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of O-6_methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- in drug resistance and strategies for its inhibition .
12483540	0	MGMT	82,86	O6-Methylguanine-DNA_Methyltransferase	42,80	MGMT	O6-Methylguanine-DNA Methyltransferase	4255	4255	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Frequent promoter hypermethylation of the O6-Methylguanine-DNA_Methyltransferase -LRB- MGMT -RRB- gene in testicular_cancer .
14647440	0	MGMT	117,121	O6-methylguanine-DNA_methyltransferase	77,115	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene expression in human cancer .
1635460	0	MGMT	74,78	O6-methylguanine-DNA_methyltransferase	34,72	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Chromosomal localization of human O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene by in situ hybridization .
2233795	0	MGMT	55,59	O6-methylguanine-DNA_methyltransferase	15,53	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The control of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- activity in mammalian cells : a pre-molecular view .
23387271	0	MGMT	128,132	O6-methylguanine-DNA_methyltransferase	88,126	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	-LSB- Bioinformatic analysis of potential post-translational modification sites of the human O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- protein -RSB- .
26261487	0	MGMT	144,148	O6-methylguanine-DNA_methyltransferase	104,142	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Overexpression of DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein in astrocytic_tumour and its correlation with O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- expression .
8565132	0	MGMT	53,57	O6-methylguanine-DNA_methyltransferase	13,51	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Targeting of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- activity by antimessenger oligonucleotide sensitizes CHO/Mex + transfected cells to mitozolomide .
8621235	0	MGMT	61,65	O6-methylguanine-DNA_methyltransferase	21,59	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Protective effect of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- on the cytotoxic and recombinogenic activity of different antineoplastic drugs .
9653449	0	MGMT	101,105	O6-methylguanine-DNA_methyltransferase	47,85	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
9653449	0	MGMT	87,91	O6-methylguanine-DNA_methyltransferase	47,85	MGMT	O6-methylguanine-DNA methyltransferase	4255	4255	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
7554086	0	MGMT	88,92	O6-methylguanine_DNA_methyltransferase	48,86	MGMT	O6-methylguanine DNA methyltransferase	4255	4255	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The role of mRNA stability and transcription in O6-methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- expression in Mer + human tumor cells .
8006031	0	MGMT	91,95	O6-methylguanine_DNA_methyltransferase	51,89	MGMT	O6-methylguanine DNA methyltransferase	4255	4255	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Graded methylation in the promoter and body of the O6-methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- gene correlates with MGMT expression in human glioma cells .
22380407	0	MGMT	89,93	methylguanine_DNA_methyltransferase	52,87	MGMT	methylguanine DNA methyltransferase	4255	4255	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	A study of clinico-pathological parameters and O - methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- promoter methylation status in the prognostication of gliosarcoma .
19419315	0	MGP	34,37	ERK1/2	62,68	MGP	ERK1/2	17313(Tax:10090)	26417;26413	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Phosphate-dependent regulation of MGP in osteoblasts : role of ERK1/2 and Fra-1 .
24228496	0	MGP	33,36	matrix_Gla-protein	13,31	MGP	matrix Gla-protein	4256	4256	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	-LSB- Analysis of matrix_Gla-protein -LRB- MGP -RRB- G-7A polymorphism association with ischemic atherothrombotic_stroke in persons with risk factors -RSB- .
1757478	0	MGP	80,83	matrix_Gla_protein	60,78	MGP	matrix Gla protein	25333(Tax:10116)	25333(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Developmental expression and hormonal regulation of the rat matrix_Gla_protein -LRB- MGP -RRB- gene in chondrogenesis and osteogenesis .
8319825	0	MGP	47,50	matrix_Gla_protein	27,45	MGP	matrix Gla protein	4256	4256	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of matrix_Gla_protein -LRB- MGP -RRB- gene expression by retinoic_acid and estrogen in human breast_carcinoma cells .
9738924	0	MGP	34,37	matrix_Gla_protein	14,32	MGP	matrix Gla protein	282660(Tax:9913)	282660(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of matrix_Gla_protein -LRB- MGP -RRB- in an in vitro model of vascular_calcification .
19306294	0	MGP	64,67	matrix_gla_protein	44,62	MGP	matrix gla protein	17313(Tax:10090)	17313(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sp proteins and Runx2 mediate regulation of matrix_gla_protein -LRB- MGP -RRB- expression by parathyroid_hormone .
19306294	0	MGP	64,67	parathyroid_hormone	83,102	MGP	parathyroid hormone	17313(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Sp proteins and Runx2 mediate regulation of matrix_gla_protein -LRB- MGP -RRB- expression by parathyroid_hormone .
16730372	0	MGR	13,16	P450scc	39,46	MGR	P450scc	317773	1583	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Human LBP-32 / MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3 .
7482442	0	MGSA	27,31	GRO_alpha	17,26	MGSA	GRO alpha	2919	2919	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Thrombin induces GRO_alpha / MGSA production in human umbilical vein endothelial cells .
7482442	0	MGSA	27,31	Thrombin	0,8	MGSA	Thrombin	2919	2147	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Thrombin induces GRO_alpha / MGSA production in human umbilical vein endothelial cells .
11380625	0	MHC	12,15	BAT1	22,26	MHC	BAT1	3133	10212	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The central MHC gene , BAT1 , may encode a protein that down-regulates cytokine production .
8870652	0	MHC	50,53	G13	9,12	MHC	G13	3133	1388	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein .
11311334	0	MHC	48,51	ICAM-1	91,97	MHC	ICAM-1	3133	3383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive and cytokine-induced expression of MHC and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on human myoblasts .
10403908	0	MHC	23,26	IFN-gamma	79,88	MHC	IFN-gamma	3133	3458	Gene	Gene	molecules|compound|START_ENTITY expression|nmod|molecules expression|appos|END_ENTITY	Impaired expression of MHC class II molecules in response to interferon-gamma -LRB- IFN-gamma -RRB- on human thymoma neoplastic epithelial cells .
12538455	0	MHC	33,36	IFN-gamma	9,18	MHC	IFN-gamma	3133	3458	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Low-dose IFN-gamma induces tumor MHC expression in metastatic malignant_melanoma .
9916700	0	MHC	25,28	IFN-gamma	0,9	MHC	IFN-gamma	3133	3458	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	IFN-gamma down-regulates MHC expression and antigen processing in a human B cell line .
7921639	0	MHC	39,42	Interferon-gamma	0,16	MHC	Interferon-gamma	3133	3458	Gene	Gene	antigens|compound|START_ENTITY expression|nmod|antigens expression|amod|END_ENTITY	Interferon-gamma induced expression of MHC antigens facilitates identification of donor cells in chimeric transplant recipients .
10725724	0	MHC	60,63	RFX-B	27,32	MHC	RFX-B	3133	8625	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class_II_transactivator in RFX-B-deficient cells .
10403908	0	MHC	23,26	interferon-gamma	61,77	MHC	interferon-gamma	3133	3458	Gene	Gene	molecules|compound|START_ENTITY molecules|nmod|response response|nmod|END_ENTITY	Impaired expression of MHC class II molecules in response to interferon-gamma -LRB- IFN-gamma -RRB- on human thymoma neoplastic epithelial cells .
3106398	0	MHC	22,25	interferon-gamma	152,168	MHC	interferon-gamma	3133	3458	Gene	Gene	_|compound|START_ENTITY induction|nmod|_ induction|dep|enhancement enhancement|nmod|expression expression|nmod|END_ENTITY	Separate induction of MHC and thyroid_microsomal_antigen _ -LRB- McAg -RRB- expression on thyroid cell monolayers : enhancement of lectin-induced McAg expression by interferon-gamma .
3135484	0	MHC	14,17	interferon-gamma	65,81	MHC	interferon-gamma	3133	25712(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of MHC protein expression in pancreatic beta-cells by interferon-gamma and tumor_necrosis_factor-alpha .
21470888	0	MHC	38,41	myosin_heavy_chain	18,36	MHC	myosin heavy chain	3133	3133	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The expression of myosin_heavy_chain -LRB- MHC -RRB- genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes .
25946330	0	MHC-II	25,31	SYK	0,3	MHC-II	SYK	111364(Tax:10090)	20963(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL .
25946330	0	MHC-II	25,31	SYK	0,3	MHC-II	SYK	111364(Tax:10090)	20963(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL .
17911618	0	MHC2TA	52,58	IFN-gamma	32,41	MHC2TA	IFN-gamma	4261	3458	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal_melanoma .
23391492	0	MHCII	15,20	Vav1	0,4	MHCII	Vav1	111364(Tax:10090)	22324(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Vav1 regulates MHCII expression in murine resting and activated B cells .
10819246	0	MHC_Class_I_chain-related_A	15,42	MIC-A	44,49	MHC Class I chain-related A	MIC-A	100507436	100507436	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of MHC_Class_I_chain-related_A -LRB- MIC-A -RRB- gene polymorphism with Type_I_diabetes .
18166336	0	MHC_II	185,191	CD11c	178,183	MHC II	CD11c	111364(Tax:10090)	16411(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Stress-induced differences in primary and secondary resistance against bacterial_sepsis corresponds with diverse corticotropin releasing hormone receptor expression by pulmonary CD11c + MHC_II + and CD11c - MHC_II + APCs .
18166336	0	MHC_II	204,210	CD11c	197,202	MHC II	CD11c	111364(Tax:10090)	16411(Tax:10090)	Gene	Gene	APCs|compound|START_ENTITY END_ENTITY|dep|APCs	Stress-induced differences in primary and secondary resistance against bacterial_sepsis corresponds with diverse corticotropin releasing hormone receptor expression by pulmonary CD11c + MHC_II + and CD11c - MHC_II + APCs .
15494508	0	MHC_class_I-related_chain_A_gene	39,71	NF-kappa_B	0,10	MHC class I-related chain A gene	NF-kappa B	100507436	4790	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappa_B regulates expression of the MHC_class_I-related_chain_A_gene in activated T lymphocytes .
18395517	0	MHC_class_I-related_chain_B	13,40	MICB	42,46	MHC class I-related chain B	MICB	4277	4277	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of MHC_class_I-related_chain_B -LRB- MICB -RRB- by 5-aza-2 ' - deoxycytidine .
10810379	0	MHC_class_I_antigen	22,41	LMP-7	84,89	MHC class I antigen	LMP-7	100507703	5696	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of MHC_class_I_antigen in human cancer cell lines with defective LMP-7 .
3093094	0	MHC_class_I_antigen	22,41	Lyt_1	77,82	MHC class I antigen	Lyt 1	547348(Tax:10090)	12507(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	402AX teratocarcinoma MHC_class_I_antigen expression is regulated in vivo by Lyt_1 , Lyt_2 , and L3T4 expressing splenic T cells .
15522921	0	MHC_class_I_chain-related_A	16,43	MICA	45,49	MHC class I chain-related A	MICA	100507436	100507436	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Contribution of MHC_class_I_chain-related_A -LRB- MICA -RRB- gene polymorphism to genetic susceptibility for systemic_lupus_erythematosus .
17130560	0	MHC_class_I_chain-related_gene-A	0,32	IA2	52,55	MHC class I chain-related gene-A	IA2	100507436	5798	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	MHC_class_I_chain-related_gene-A is associated with IA2 and IAA but not GAD in Swedish type_1_diabetes_mellitus .
16151576	0	MHC_class_I_chain-related_gene_A	0,32	MICA	34,38	MHC class I chain-related gene A	MICA	100507436	100507436	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	MHC_class_I_chain-related_gene_A -LRB- MICA -RRB- polymorphism and the different histological types of cervical_cancer .
24461475	0	MHC_class_I_polypeptide-related_sequence_A	42,84	Matrix_metallopeptidase_2	0,25	MHC class I polypeptide-related sequence A	Matrix metallopeptidase 2	100507436	4313	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Matrix_metallopeptidase_2 -LRB- MMP2 -RRB- mediates MHC_class_I_polypeptide-related_sequence_A -LRB- MICA -RRB- shedding in renal_cell_carcinoma .
15089901	0	MHC_class_I_related_gene_B	15,41	MICB	43,47	MHC class I related gene B	MICB	4277	4277	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of MHC_class_I_related_gene_B -LRB- MICB -RRB- to celiac_disease .
11483763	0	MHVR	36,40	Ceacam1	27,34	MHVR	Ceacam1	26365(Tax:10090)	26365(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Targeted disruption of the Ceacam1 -LRB- MHVR -RRB- gene leads to reduced susceptibility of mice to mouse_hepatitis_virus_infection .
17977671	0	MIA	153,156	CD-RAP	115,121	MIA	CD-RAP	100064799(Tax:9796)	8190	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Molecular characterization and chromosomal assignment of equine cartilage derived retinoic_acid sensitive protein -LRB- CD-RAP -RRB- / melanoma_inhibitory_activity -LRB- MIA -RRB- .
15170138	0	MIA	65,68	S100	26,30	MIA	S100	8190	6271	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Clinical value of protein S100 and melanoma-inhibitory_activity -LRB- MIA -RRB- in malignant_melanoma .
11027436	0	MIA	48,51	melanoma_inhibitory_activity	18,46	MIA	melanoma inhibitory activity	8190	8190	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of melanoma_inhibitory_activity -LRB- MIA -RRB- enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo .
11157741	0	MIA	54,57	melanoma_inhibitory_activity	24,52	MIA	melanoma inhibitory activity	8190	8190	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The extracellular human melanoma_inhibitory_activity -LRB- MIA -RRB- protein adopts an SH3 domain-like fold .
15201979	0	MIB-1	65,70	p53	43,46	MIB-1	p53	57534	7157	Gene	Gene	HER-2|amod|START_ENTITY expression|amod|HER-2 expression|nmod|END_ENTITY	Relation between HPV-DNA and expression of p53 , bcl-2 , p21WAF-1 , MIB-1 , HER-2 / neu and DNA ploidy in early cervical carcinoma : correlation with clinical outcome .
16328355	0	MIB-1	46,51	p53	58,61	MIB-1	p53	57534	7157	Gene	Gene	p16|compound|START_ENTITY p16|nummod|END_ENTITY	Expression of cell cycle-regulatory proteins , MIB-1 , p16 , p53 , and p63 , in squamous_cell_carcinoma of conjunctiva : not associated with human_papillomavirus_infection .
20414055	0	MIB-1	65,70	p53	42,45	MIB-1	p53	57534	7157	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|protein protein|compound|END_ENTITY	Immunohistochemical overexpression of the p53 protein and Ki-67 -LRB- MIB-1 -RRB- antigen in patients with GERD and chronic_esophagitis .
20598040	0	MIB-1	30,35	p53	15,18	MIB-1	p53	57534	7157	Gene	Gene	expressions|appos|START_ENTITY expressions|amod|END_ENTITY	Correlation of p53 and Ki-67 -LRB- MIB-1 -RRB- expressions with clinicopathological features and prognosis of early stage cervical squamous_cell_carcinomas .
8735719	0	MIB-1	0,5	p53	130,133	MIB-1	p53	57534	7157	Gene	Gene	expression|compound|START_ENTITY expression|dep|study study|nmod|correlations correlations|nmod|characteristics characteristics|amod|END_ENTITY	MIB-1 expression and iododeoxyuridine labelling in soft tissue sarcomas : an immunohistochemical study including correlations with p53 , bcl-2 and histological characteristics .
9477105	0	MIB-1	112,117	p53	107,110	MIB-1	p53	57534	7157	Gene	Gene	grade|amod|START_ENTITY grade|nmod|END_ENTITY	Invasion of the bladder_by_transitional_cell_carcinoma : its relation to histologic grade and expression of p53 , MIB-1 , c-erb_B-2 , epidermal_growth_factor_receptor , and bcl-2 .
9493195	0	MIB-1	73,78	p53	17,20	MIB-1	p53	57534	7157	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Significance of p53 protein expression and proliferative potential with MIB-1 on tumor recurrence of pituitary_adenomas -RSB- .
16006797	0	MIB1	134,138	BCL2	140,144	MIB1	BCL2	57534	596	Gene	Gene	neu|dep|START_ENTITY neu|dep|END_ENTITY	An immunohistochemical comparison between low-grade and high-grade ovarian_serous_carcinomas : significantly higher expression of p53 , MIB1 , BCL2 , HER-2 / neu , and C-KIT in high-grade neoplasms .
16006797	0	MIB1	134,138	p53	129,132	MIB1	p53	57534	7157	Gene	Gene	neu|dep|START_ENTITY neu|compound|END_ENTITY	An immunohistochemical comparison between low-grade and high-grade ovarian_serous_carcinomas : significantly higher expression of p53 , MIB1 , BCL2 , HER-2 / neu , and C-KIT in high-grade neoplasms .
11579380	5	MIC-1	1004,1009	GDF-15	997,1003	MIC-1	GDF-15	9518	29455(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Unilateral cryogenic cortical lesioning induced a significant increase of GDF-15 / MIC-1 mRNA expression and ir at the lesion site and expression in presumed neurons within the dorsal thalamic area .
19133249	0	MIC-1	64,69	macrophage_inhibitory_cytokine-1	30,62	MIC-1	macrophage inhibitory cytokine-1	9518	9518	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation and secretion of macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- in gastric_cancers .
23836903	0	MIC-1	92,97	macrophage_inhibitory_cytokine-1	58,90	MIC-1	macrophage inhibitory cytokine-1	9518	9518	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	RNPC1 , an RNA-binding protein and a p53 target , regulates macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- expression through mRNA stability .
12082608	0	MIC-1	49,54	p53	95,98	MIC-1	p53	9518	7157	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Anoxia induces macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- in glioblastoma cells independently of p53 and HIF-1 .
11556754	0	MIC-2	144,149	CD99	138,142	MIC-2	CD99	4267	4267	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical detection of EWS and FLI-1 proteinss in Ewing_sarcoma and primitive_neuroectodermal_tumors : comparative analysis with CD99 -LRB- MIC-2 -RRB- expression .
10819246	0	MIC-A	44,49	MHC_Class_I_chain-related_A	15,42	MIC-A	MHC Class I chain-related A	100507436	100507436	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of MHC_Class_I_chain-related_A -LRB- MIC-A -RRB- gene polymorphism with Type_I_diabetes .
10354133	0	MIC2	6,10	CD99	0,4	MIC2	CD99	4267	4267	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CD99 -LRB- MIC2 -RRB- expression in paediatric B-lineage leukaemia/lymphoma reflects maturation-associated patterns of normal B-lymphopoiesis .
10786814	0	MIC2	20,24	CD99	26,30	MIC2	CD99	4267	4267	Gene	Gene	Immunoreactivity|nmod|START_ENTITY Immunoreactivity|appos|END_ENTITY	Immunoreactivity of MIC2 -LRB- CD99 -RRB- in acute_myelogenous_leukemia and related_diseases .
17570210	0	MICA	91,95	CD4	0,3	MICA	CD4	100507436	920	Gene	Gene	interactions|compound|START_ENTITY mediate|nmod|interactions T|ccomp|mediate T|nsubj|+ +|compound|END_ENTITY	CD4 + NKG2D + T cells in Crohn 's _ disease mediate inflammatory and cytotoxic responses through MICA interactions .
22215138	0	MICA	109,113	ERp5	14,18	MICA	ERp5	100507436	10130	Gene	Gene	association|nmod|START_ENTITY Expression|dep|association Expression|nmod|END_ENTITY	Expression of ERp5 and GRP78 on the membrane of chronic_lymphocytic_leukemia cells : association with soluble MICA shedding .
21092233	0	MICA	35,39	HIF-1	12,17	MICA	HIF-1	100507436	3091	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of HIF-1 in up-regulating MICA expression on human renal proximal tubular epithelial cells during hypoxia/reoxygenation .
19895570	0	MICA	0,4	HLA-B	39,44	MICA	HLA-B	100507436	3106	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|nmod|END_ENTITY	MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans .
22302133	0	MICA	50,54	Interleukin-1b	0,14	MICA	Interleukin-1b	100507436	3553	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interleukin-1b enhances the production of soluble MICA in human hepatocellular_carcinoma .
20714339	0	MICA	25,29	Interleukin_10	0,14	MICA	Interleukin 10	100507436	3586	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Interleukin_10 decreases MICA expression on melanoma cell surface .
15522921	0	MICA	45,49	MHC_class_I_chain-related_A	16,43	MICA	MHC class I chain-related A	100507436	100507436	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Contribution of MHC_class_I_chain-related_A -LRB- MICA -RRB- gene polymorphism to genetic susceptibility for systemic_lupus_erythematosus .
16151576	0	MICA	34,38	MHC_class_I_chain-related_gene_A	0,32	MICA	MHC class I chain-related gene A	100507436	100507436	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	MHC_class_I_chain-related_gene_A -LRB- MICA -RRB- polymorphism and the different histological types of cervical_cancer .
21143201	0	MICA	14,18	MMP9	0,4	MICA	MMP9	100507436	4318	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	MMP9 mediates MICA shedding in human osteosarcomas .
11323699	0	MICA	89,93	NKG2D	51,56	MICA	NKG2D	100507436	22914	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|structure structure|nmod|END_ENTITY	Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA .
11491531	0	MICA	45,49	NKG2D	22,27	MICA	NKG2D	100507436	22914	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of human NKG2D with its ligands MICA , MICB , and homologs of the mouse RAE-1 protein family .
16750166	0	MICA	36,40	NKG2D	23,28	MICA	NKG2D	100507436	22914	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of the NKG2D ligand MICA by the human_cytomegalovirus glycoprotein UL142 .
17570210	0	MICA	91,95	NKG2D	4,9	MICA	NKG2D	100507436	22914	Gene	Gene	interactions|compound|START_ENTITY mediate|nmod|interactions T|ccomp|mediate T|nsubj|+ +|compound|END_ENTITY	CD4 + NKG2D + T cells in Crohn 's _ disease mediate inflammatory and cytotoxic responses through MICA interactions .
18981088	0	MICA	102,106	NKG2D	89,94	MICA	NKG2D	100507436	22914	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Interaction Interaction|nmod|monocytes monocytes|nmod|cells cells|nmod|expression expression|nmod|END_ENTITY	Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA .
19793804	0	MICA	13,17	NKG2D	0,5	MICA	NKG2D	100507436	22914	Gene	Gene	retained|nsubjpass|START_ENTITY ligand|ccomp|retained ligand|nsubj|END_ENTITY	NKG2D ligand MICA is retained in the cis-Golgi apparatus by human_cytomegalovirus protein UL142 .
21928280	0	MICA	18,22	NKG2D	37,42	MICA	NKG2D	100507436	22914	Gene	Gene	Palmitoylation|nmod|START_ENTITY Palmitoylation|appos|ligand ligand|nmod|END_ENTITY	Palmitoylation of MICA , a ligand for NKG2D , mediates its recruitment to membrane microdomains and promotes its shedding .
23686482	0	MICA	64,68	NKG2D	51,56	MICA	NKG2D	100507436	22914	Gene	Gene	expression|compound|START_ENTITY ligand|dobj|expression ligand|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple_myeloma cells : role of STAT3 .
23860405	0	MICA	84,88	NKG2D	55,60	MICA	NKG2D	100507436	22914	Gene	Gene	expression|compound|START_ENTITY regulating|dobj|expression modulate|advcl|regulating modulate|dobj|activity activity|compound|END_ENTITY	Endothelial cell activation and proliferation modulate NKG2D activity by regulating MICA expression and shedding .
24846123	0	MICA	16,20	NKG2D	44,49	MICA	NKG2D	100507436	22914	Gene	Gene	START_ENTITY|dep|not not|nmod|down-modulation down-modulation|amod|ULBP2-induced ULBP2-induced|dep|END_ENTITY	c-Cbl regulates MICA - but not ULBP2-induced NKG2D down-modulation in human NK cells .
26909862	0	MICA	36,40	NKG2D	52,57	MICA	NKG2D	100507436	22914	Gene	Gene	immunosurveillance|compound|START_ENTITY immunosurveillance|compound|END_ENTITY	VEGFR2 targeted antibody fused with MICA stimulates NKG2D mediated immunosurveillance and exhibits potent anti-tumor activity against breast_cancer .
18208618	0	MICA	83,87	major_histocompatibility_complex_class_I-related_chain_A	25,81	MICA	major histocompatibility complex class I-related chain A	100507436	100507436	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Augmented serum level of major_histocompatibility_complex_class_I-related_chain_A -LRB- MICA -RRB- protein and reduced NKG2D expression on NK and T cells in patients with cervical_cancer and precursor lesions .
16906033	0	MICA	99,103	major_histocompatibility_complex_class_I_chain-related_molecule_A	32,97	MICA	major histocompatibility complex class I chain-related molecule A	100507436	100507436	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The predictive value of soluble major_histocompatibility_complex_class_I_chain-related_molecule_A -LRB- MICA -RRB- levels on heart allograft rejection .
19864458	0	MICAL-L1	0,8	EHD1	15,19	MICAL-L1	EHD1	85377	10938	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	MICAL-L1 links EHD1 to tubular recycling endosomes and regulates receptor recycling .
25403488	0	MICAL3	69,75	PAX5	79,83	MICAL3	PAX5	57553	5079	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	miR-648 targets ET-1 mRNA and is co-transcriptionally regulated with MICAL3 by PAX5 .
18395517	0	MICB	42,46	MHC_class_I-related_chain_B	13,40	MICB	MHC class I-related chain B	4277	4277	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of MHC_class_I-related_chain_B -LRB- MICB -RRB- by 5-aza-2 ' - deoxycytidine .
15089901	0	MICB	43,47	MHC_class_I_related_gene_B	15,41	MICB	MHC class I related gene B	4277	4277	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of MHC_class_I_related_gene_B -LRB- MICB -RRB- to celiac_disease .
21664939	0	MICB	87,91	major_histocompatibility_complex_class_I_chain-related_gene_B	24,85	MICB	major histocompatibility complex class I chain-related gene B	4277	4277	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Characterization of the major_histocompatibility_complex_class_I_chain-related_gene_B -LRB- MICB -RRB- polymorphism in a northern Chinese Han population : the identification of a new MICB allele , MICB * 023 .
22245785	0	MICS-1	0,6	ATAD-3	36,42	MICS-1	ATAD-3	179475(Tax:6239)	174590(Tax:6239)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. _ elegans .
26336993	0	MICU1	75,80	RPS3	0,4	MICU1	RPS3	10367	6188	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto_C / Ca2 + / MICU1 dependent mitochondrial signaling .
14726168	0	MIC_1	58,63	macrophage_inhibitory_cytokine_1	24,56	MIC 1	macrophage inhibitory cytokine 1	9518	9518	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of macrophage_inhibitory_cytokine_1 -LRB- MIC_1 -RRB- as a predictor of miscarriage .
21930711	0	MID1	56,60	3-phosphoinositide-dependent_protein_kinase-1	133,178	MID1	3-phosphoinositide-dependent protein kinase-1	4281	5170	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Protein phosphatase 2A -LRB- PP2A -RRB- - specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent_protein_kinase-1 -LRB- PDPK-1 -RRB- .
25216264	0	MID1	27,31	Bbox1	32,37	MID1	Bbox1	4281	8424	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding .
25874572	0	MID1	115,119	Bbox1	133,138	MID1	Bbox1	4281	8424	Gene	Gene	Domain|compound|START_ENTITY Domain|compound|END_ENTITY	Molecular Dynamics Simulation Reveals Insights into the Mechanism of Unfolding by the A130T/V Mutations within the MID1 Zinc-Binding Bbox1 Domain .
25874572	0	MID1	115,119	Bbox1	133,138	MID1	Bbox1	4281	8424	Gene	Gene	Domain|compound|START_ENTITY Domain|compound|END_ENTITY	Molecular Dynamics Simulation Reveals Insights into the Mechanism of Unfolding by the A130T/V Mutations within the MID1 Zinc-Binding Bbox1 Domain .
20627078	0	MID1	48,52	MADD-2	0,6	MID1	MADD-2	4281	178619(Tax:6239)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	MADD-2 , a homolog of the Opitz_syndrome protein MID1 , regulates guidance to the midline through UNC-40 in Caenorhabditis_elegans .
10400986	0	MID1	45,49	MID2	0,4	MID1	MID2	17318(Tax:10090)	23947(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	MID2 , a homologue of the Opitz_syndrome gene MID1 : similarities in subcellular localization and differences in expression during development .
10400986	0	MID2	0,4	MID1	45,49	MID2	MID1	23947(Tax:10090)	17318(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	MID2 , a homologue of the Opitz_syndrome gene MID1 : similarities in subcellular localization and differences in expression during development .
21701560	0	MIEF1	6,11	Drp1	21,25	MIEF1	Drp1	54471	10059	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission .
19428548	0	MIF	67,70	CD4	80,83	MIF	CD4	4282	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	NF-kappaB inhibition leads to increased synthesis and secretion of MIF in human CD4 + T cells .
18842989	0	MIF	4,7	CD74	17,21	MIF	CD74	4282	972	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	The MIF receptor CD74 in diabetic_podocyte_injury .
23044992	0	MIF	29,32	CD74	12,16	MIF	CD74	17319(Tax:10090)	16149(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Deletion of CD74 , a putative MIF receptor , in mice enhances osteoclastogenesis and decreases bone mass .
24760155	0	MIF	0,3	CXCR4	53,58	MIF	CXCR4	17319(Tax:10090)	12767(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling .
26139098	0	MIF	0,3	CXCR7	19,24	MIF	CXCR7	4282	57007	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MIF interacts with CXCR7 to promote receptor internalization , ERK1/2 and ZAP-70 signaling , and lymphocyte chemotaxis .
26139098	0	MIF	0,3	CXCR7	19,24	MIF	CXCR7	4282	57007	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MIF interacts with CXCR7 to promote receptor internalization , ERK1/2 and ZAP-70 signaling , and lymphocyte chemotaxis .
24504014	0	MIF	43,46	Developmental_endothelial_locus-1	0,33	MIF	Developmental endothelial locus-1	17319(Tax:10090)	13612(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Developmental_endothelial_locus-1 inhibits MIF production through suppression of NF-kB in macrophages .
26314331	0	MIF	0,3	EGFR	37,41	MIF	EGFR	4282	1956	Gene	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|nmod|END_ENTITY	MIF Is an Extracellular Inhibitor of EGFR .
26280537	0	MIF	28,31	EGF_receptor	51,63	MIF	EGF receptor	4282	1956	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Secreted and O-GlcNAcylated MIF binds to the human EGF_receptor and inhibits its activation .
10233671	0	MIF	90,93	HLA-DRB1	105,113	MIF	HLA-DRB1	4282	3123	Gene	Gene	peptide|compound|START_ENTITY peptide|nmod|END_ENTITY	Human B cells secrete migration_inhibition_factor -LRB- MIF -RRB- and present a naturally processed MIF peptide on HLA-DRB1 * 0405 by a FXXL motif .
26752645	0	MIF	42,45	ICBP90	21,27	MIF	ICBP90	4282	29128	Gene	Gene	promoter|compound|START_ENTITY regulates|dobj|promoter regulates|nsubj|END_ENTITY	Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus .
26752192	0	MIF	4,7	ISO-1	19,24	MIF	ISO-1	4282	10209	Gene	Gene	Inflammation|compound|START_ENTITY Inflammation|compound|END_ENTITY	The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD .
27057101	0	MIF	0,3	Ly6C	65,69	MIF	Ly6C	17319(Tax:10090)	17067(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	MIF Promotes Classical Activation and Conversion of Inflammatory Ly6C -LRB- high -RRB- Monocytes into TipDCs during Murine Toxoplasmosis .
9158105	0	MIF	95,98	M-CSF	55,60	MIF	M-CSF	81683(Tax:10116)	78965(Tax:10116)	Gene	Gene	macrophage_colony-stimulating_factor|appos|START_ENTITY macrophage_colony-stimulating_factor|appos|END_ENTITY	Up-regulation of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- and migration_inhibitory_factor -LRB- MIF -RRB- expression and monocyte recruitment during lipid-induced glomerular_injury in the exogenous hypercholesterolaemic -LRB- ExHC -RRB- rat .
23985752	0	MIF	86,89	Macrophage_Migration_Inhibitory_Factor	46,84	MIF	Macrophage Migration Inhibitory Factor	4282	4282	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Chemokines mRNA expression in relation to the Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- mRNA and Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- mRNA expression in the microenvironment of endometrial_cancer tissue and normal endometrium : a pilot study .
24281172	0	MIF	52,55	Macrophage_Migration_Inhibitory_Factor	12,50	MIF	Macrophage Migration Inhibitory Factor	4282	4282	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- in Ultraviolet Radiation-Induced Carcinogenesis .
24826917	0	MIF	68,71	Macrophage_Migration_Inhibitory_Factor	28,66	MIF	Macrophage Migration Inhibitory Factor	4282	4282	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Hypoxia Signaling Regulates Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- Expression in Stroke .
25647395	0	MIF	48,51	Macrophage_Migration_Inhibitory_Factor	8,46	MIF	Macrophage Migration Inhibitory Factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- in Pollen-Induced Allergic_Conjunctivitis and Pollen Dermatitis in Mice .
12445161	0	MIF	40,43	Macrophage_migration_inhibitory_factor	0,38	MIF	Macrophage migration inhibitory factor	4282	4282	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in human glioblastomas correlates with vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
17728788	0	MIF	40,43	Macrophage_migration_inhibitory_factor	0,38	MIF	Macrophage migration inhibitory factor	4282	4282	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene polymorphisms are associated with increased_prostate_cancer incidence .
21773885	0	MIF	40,43	Macrophage_migration_inhibitory_factor	0,38	MIF	Macrophage migration inhibitory factor	4282	4282	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in human malignant_gliomas contributes to immune escape and tumour progression .
24951298	0	MIF	40,43	Macrophage_migration_inhibitory_factor	0,38	MIF	Macrophage migration inhibitory factor	4282	4282	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- -173 polymorphism is associated with clinical erythema_nodosum in L __ fgren 's _ syndrome .
24138931	0	MIF	55,58	MiR-451	0,7	MIF	MiR-451	4282	574411	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-451 inhibits cell growth and invasion by targeting MIF and is associated with survival in nasopharyngeal_carcinoma .
20829434	0	MIF	41,44	NURR1	18,23	MIF	NURR1	4282	4929	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	Identification of NURR1 as a mediator of MIF signaling during chronic arthritis : effects on glucocorticoid-induced MKP1 .
21269946	0	MIF	41,44	THP-1	88,93	MIF	THP-1	4282	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|macrophages macrophages|compound|END_ENTITY	Effect of asymmetric dimethylarginine on MIF expression and TNF-a and IL-8 secretion in THP-1 monocytes-derived macrophages .
9085256	0	MIF	29,32	TNF-alpha	0,9	MIF	TNF-alpha	81683(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNF-alpha up-regulates renal MIF expression in rat crescentic glomerulonephritis .
19530702	0	MIF	44,47	epidermal_growth_factor_receptor	52,84	MIF	epidermal growth factor receptor	4282	1956	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of macrophage_inhibitory_factor -LRB- MIF -RRB- by epidermal_growth_factor_receptor -LRB- EGFR -RRB- in the MCF10AT model of breast_cancer_progression .
19530702	0	MIF	44,47	macrophage_inhibitory_factor	14,42	MIF	macrophage inhibitory factor	4282	4282	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of macrophage_inhibitory_factor -LRB- MIF -RRB- by epidermal_growth_factor_receptor -LRB- EGFR -RRB- in the MCF10AT model of breast_cancer_progression .
24272203	0	MIF	56,59	macrophage_migration-inhibitory_factor	16,54	MIF	macrophage migration-inhibitory factor	4282	4282	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of macrophage_migration-inhibitory_factor -LRB- MIF -RRB- have diagnostic , predictive and prognostic roles in epithelial_ovarian_cancer patients .
10404515	0	MIF	62,65	macrophage_migration_inhibitory_factor	22,60	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	An essential role for macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in angiogenesis and the growth of a murine lymphoma .
10415161	0	MIF	54,57	macrophage_migration_inhibitory_factor	14,52	MIF	macrophage migration inhibitory factor	81683(Tax:10116)	103694877	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression by glucose and insulin in adipocytes in vitro .
10576686	0	MIF	54,57	macrophage_migration_inhibitory_factor	14,52	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- tautomerase activity by dopachrome analogs .
10776792	0	MIF	63,66	macrophage_migration_inhibitory_factor	23,61	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	Different influence of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in signal transduction pathway of various T cell subsets .
10865055	0	MIF	84,87	macrophage_migration_inhibitory_factor	44,82	MIF	macrophage migration inhibitory factor	103694877	103694877	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Expression and glucocorticoid regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in hippocampal and neocortical rat brain cells in culture .
10877450	0	MIF	48,51	macrophage_migration_inhibitory_factor	8,46	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in allergic and endotoxin-induced airway inflammation in mice .
11118621	0	MIF	95,98	macrophage_migration_inhibitory_factor	55,93	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Japanese_encephalitis_virus up-regulates expression of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- mRNA in the mouse brain .
11126199	0	MIF	55,58	macrophage_migration_inhibitory_factor	15,53	MIF	macrophage migration inhibitory factor	81683(Tax:10116)	103694877	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in experimental uric_acid nephropathy .
11773615	0	MIF	54,57	macrophage_migration_inhibitory_factor	14,52	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- tautomerase and biological activities by acetaminophen metabolites .
12070782	0	MIF	82,85	macrophage_migration_inhibitory_factor	42,80	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A functional promoter polymorphism in the macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene associated with disease severity in rheumatoid_arthritis .
14574584	0	MIF	76,79	macrophage_migration_inhibitory_factor	36,74	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in human gingival tissue and its pathophysiological functions .
15654833	0	MIF	49,52	macrophage_migration_inhibitory_factor	9,47	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Elevated macrophage_migration_inhibitory_factor -LRB- MIF -RRB- levels in the urine of patients with focal_glomerular_sclerosis .
15659324	0	MIF	48,51	macrophage_migration_inhibitory_factor	8,46	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in the skin .
15821118	0	MIF	65,68	macrophage_migration_inhibitory_factor	25,63	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucocorticoids suppress macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in a cell-type-specific manner .
16077028	0	MIF	105,108	macrophage_migration_inhibitory_factor	65,103	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Simultaneous detection of microsatellite repeats and SNPs in the macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene by thin-film biosensor chips and application to rural field studies .
16461006	0	MIF	62,65	macrophage_migration_inhibitory_factor	22,60	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Decreased circulating macrophage_migration_inhibitory_factor -LRB- MIF -RRB- protein and blood mononuclear cell MIF transcripts in children with Plasmodium_falciparum_malaria .
16682188	0	MIF	118,121	macrophage_migration_inhibitory_factor	78,116	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- tautomerase activity .
16854377	0	MIF	59,62	macrophage_migration_inhibitory_factor	19,57	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Dual regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in hypoxia by CREB and HIF-1 .
16860715	0	MIF	50,53	macrophage_migration_inhibitory_factor	10,48	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- on acute_graft-versus-host_disease in a murine model of allogeneic stem cell transplantation .
18081874	0	MIF	46,49	macrophage_migration_inhibitory_factor	6,44	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum macrophage_migration_inhibitory_factor -LRB- MIF -RRB- levels after allogeneic hematopoietic stem cell transplantation .
18347935	0	MIF	64,67	macrophage_migration_inhibitory_factor	24,62	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The diagnostic value of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in gastric_cancer .
19394321	0	MIF	52,55	macrophage_migration_inhibitory_factor	12,50	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Increase of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in cardiomyocytes during chronic hypoxia .
19464392	0	MIF	52,55	macrophage_migration_inhibitory_factor	12,50	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in patients with idiopathic_pulmonary_fibrosis .
19602265	0	MIF	53,56	macrophage_migration_inhibitory_factor	13,51	MIF	Macrophage migration inhibitory factor	4282	4282	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Dual role of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in human breast_cancer .
19747950	0	MIF	79,82	macrophage_migration_inhibitory_factor	39,77	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Histone deacetylase inhibitors repress macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression by targeting MIF gene transcription through a local chromatin deacetylation .
20093039	0	MIF	102,105	macrophage_migration_inhibitory_factor	62,100	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization and functional analysis of porcine macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene .
20169062	0	MIF	67,70	macrophage_migration_inhibitory_factor	27,65	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in melioidosis .
20621719	0	MIF	97,100	macrophage_migration_inhibitory_factor	57,95	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between functional promoter polymorphisms of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene and ulcerative_colitis in Japan .
21536912	0	MIF	90,93	macrophage_migration_inhibitory_factor	50,88	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Thyroxine is a potential endogenous antagonist of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- activity .
21641401	0	MIF	50,53	macrophage_migration_inhibitory_factor	10,48	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in human placental explants infected with Toxoplasma_gondii depends on gestational age .
21730129	0	MIF	58,61	macrophage_migration_inhibitory_factor	18,56	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role for macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in Ross_River_virus-induced arthritis and myositis .
22476444	0	MIF	69,72	macrophage_migration_inhibitory_factor	29,67	MIF	macrophage migration inhibitory factor	595146(Tax:9615)	595146(Tax:9615)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in feeding American dog ticks , Dermacentor variabilis .
23721694	0	MIF	59,62	macrophage_migration_inhibitory_factor	19,57	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A genetic role for macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in adult-onset_Still 's _ disease .
24916123	0	MIF	61,64	macrophage_migration_inhibitory_factor	21,59	MIF	macrophage migration inhibitory factor	4282	4282	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Potent inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- by myeloperoxidase-dependent oxidation of epicatechins .
9203559	0	MIF	76,79	macrophage_migration_inhibitory_factor	36,74	MIF	macrophage migration inhibitory factor	81683(Tax:10116)	103694877	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in tanycytes , subcommissural organ and choroid plexus in the rat brain .
9932108	0	MIF	55,58	macrophage_migration_inhibitory_factor	15,53	MIF	macrophage migration inhibitory factor	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in the mechanism of tumor cell growth .
37848	0	MIF	18,21	melanocyte-stimulating_hormone-release_inhibiting_factor	23,79	MIF	melanocyte-stimulating hormone-release inhibiting factor	4282	4282	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	-LSB- The influence of MIF -LRB- melanocyte-stimulating_hormone-release_inhibiting_factor -RRB- on psychomotor function and mood in parkinsonian patients .
4614981	0	MIF	68,71	melanocyte-stimulating_hormone-release_inhibiting_factor	10,66	MIF	melanocyte-stimulating hormone-release inhibiting factor	4282	4282	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of melanocyte-stimulating_hormone-release_inhibiting_factor -LRB- MIF -RRB- in Parkinson 's _ syndrom .
21485220	0	MIF	55,58	migration_inhibition_factor	26,53	MIF	migration inhibition factor	4282	4282	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of macrophage migration_inhibition_factor -LRB- MIF -RRB- in serum of patients with prostate_cancer and its clinical significance -RSB- .
6458429	0	MIF	43,46	migration_inhibition_factor	14,41	MIF	migration inhibition factor	4282	4282	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of migration_inhibition_factor -LRB- MIF -RRB- by purified human T cell subpopulations .
1090541	0	MIF	63,66	migration_inhibitory_factor	34,61	MIF	migration inhibitory factor	4282	4282	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Intracellular localization of the migration_inhibitory_factor -LRB- MIF -RRB- in a long-term human lymphoid cell line .
370028	2	MIF	100,103	migration_inhibitory_factor	71,98	MIF	migration inhibitory factor	4282	4282	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of migration_inhibitory_factor -LRB- MIF -RRB- on macrophage microtubules .
18980207	0	MIG	30,33	CXCL9	23,28	MIG	CXCL9	4283	4283	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abundant expression of CXCL9 -LRB- MIG -RRB- by stromal cells that include dendritic_cells and accumulation of CXCR3 + T cells in lymphocyte-rich gastric_carcinoma .
18980207	0	MIG	30,33	CXCR3	101,106	MIG	CXCR3	4283	2833	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|acl:relcl|include include|dobj|dendritic_cells dendritic_cells|nmod|+ +|compound|END_ENTITY	Abundant expression of CXCL9 -LRB- MIG -RRB- by stromal cells that include dendritic_cells and accumulation of CXCR3 + T cells in lymphocyte-rich gastric_carcinoma .
15959530	0	MIG	123,126	monokine_induced_by_interferon-gamma	85,121	MIG	monokine induced by interferon-gamma	17329(Tax:10090)	17329(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple_myeloma oncogene 1 -LRB- MUM1 -RRB- / interferon_regulatory_factor_4 -LRB- IRF4 -RRB- upregulates monokine_induced_by_interferon-gamma -LRB- MIG -RRB- gene expression in B-cell malignancy .
26828323	0	MIG	46,49	monokine_induced_by_interferon-gamma	8,44	MIG	monokine induced by interferon-gamma	4283	4283	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of monokine_induced_by_interferon-gamma -LRB- MIG -RRB- in discrimination and prognosis of patients with Chagas ' _ disease and idiopathic_dilated_cardiomyopathy .
23209429	0	MIG-10	0,6	ABI-1	22,27	MIG-10	ABI-1	5230	10006	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways .
21937599	0	MIG-15	0,6	UNC-116	74,81	MIG-15	UNC-116	181248(Tax:6239)	176179(Tax:6239)	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|END_ENTITY	MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1 .
26239118	0	MIG6	28,32	DNAJB1	0,6	MIG6	DNAJB1	54206	3337	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	DNAJB1 negatively regulates MIG6 to promote epidermal_growth_factor_receptor signaling .
24425048	0	MIG6	51,55	EGFR	76,80	MIG6	EGFR	54206	1956	Gene	Gene	targets|dobj|START_ENTITY targets|xcomp|regulate regulate|dobj|END_ENTITY	microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastoma .
25873164	0	MIIP	96,100	migration_and_invasion_inhibitory_protein	53,94	MIIP	migration and invasion inhibitory protein	60672	60672	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Altered expression and loss of heterozygosity of the migration_and_invasion_inhibitory_protein -LRB- MIIP -RRB- gene in breast_cancer .
25873164	0	MIIP	96,100	migration_and_invasion_inhibitory_protein	53,94	MIIP	migration and invasion inhibitory protein	60672	60672	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Altered expression and loss of heterozygosity of the migration_and_invasion_inhibitory_protein -LRB- MIIP -RRB- gene in breast_cancer .
16337592	0	MINK	15,19	Ste20	23,28	MINK	Ste20	50488	8428	Gene	Gene	START_ENTITY|appos|kinase kinase|amod|END_ENTITY	Involvement of MINK , a Ste20 family kinase , in Ras oncogene-induced growth_arrest in human_ovarian_surface_epithelial cells .
7525161	0	MIP	45,48	AQP2	6,10	MIP	AQP2	4284	359	Gene	Gene	family|compound|START_ENTITY members|nmod|family END_ENTITY|appos|members	Human AQP2 and MIP genes , two members of the MIP family , map within chromosome band 12q13 on the basis of two-color FISH .
7504555	0	MIP	21,24	DIP	0,3	MIP	DIP	280859(Tax:9913)	613430(Tax:9913)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	DIP : a member of the MIP family of membrane proteins that is expressed in mature seeds and dark-grown seedlings of Antirrhinum majus .
11852078	0	MIP	70,73	main_intrinsic_protein	46,68	MIP	main intrinsic protein	25480(Tax:10116)	25480(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Heterologous expression and topography of the main_intrinsic_protein -LRB- MIP -RRB- from rat lens .
22792407	0	MIP-1	0,5	NFATc1	18,24	MIP-1	NFATc1	238799(Tax:10090)	18018(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	MIP-1 activates NFATc1 and enhances osteoclastogenesis : involvement of both PLCy2 and NFkB signaling .
18619972	0	MIP-1_alpha	6,17	CCL3	0,4	MIP-1 alpha	CCL3	6348	6348	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	CCL3 -LRB- MIP-1_alpha -RRB- levels are elevated during acute_coronary_syndromes and show strong prognostic power for future ischemic events .
7536684	0	MIP-1_alpha	53,64	CD34	145,149	MIP-1 alpha	CD34	6348	947	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nmod|proliferation proliferation|nmod|subpopulations subpopulations|nmod|cells cells|nummod|END_ENTITY	Differential effects of the hematopoietic inhibitors MIP-1_alpha , TGF-beta , and TNF-alpha on cytokine-induced proliferation of subpopulations of CD34 + cells purified from cord blood and fetal liver .
7539383	0	MIP-1_alpha	72,83	CD34	103,107	MIP-1 alpha	CD34	6348	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Comparison of the inhibitory effect of AcSDKP , TNF-alpha , TGF-beta , and MIP-1_alpha on marrow-purified CD34 + progenitors .
9766815	0	MIP-1_alpha	81,92	CD34	25,29	MIP-1 alpha	CD34	6348	947	Gene	Gene	blood|nmod|START_ENTITY isolated|nmod|blood isolated|nsubj|response response|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Differential response of CD34 + cells isolated from cord blood and bone marrow to MIP-1_alpha and the expression of MIP-1_alpha receptors on these immature cells .
7906962	0	MIP-1_alpha	78,89	Intercellular_adhesion_molecule-1	0,33	MIP-1 alpha	Intercellular adhesion molecule-1	6348	3383	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Intercellular_adhesion_molecule-1 mediates the expression of monocyte-derived MIP-1_alpha during monocyte-endothelial cell interactions .
12427015	0	MIP-1_beta	46,56	CCR5	60,64	MIP-1 beta	CCR5	6351	1234	Gene	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Characterization of the role of the N-loop of MIP-1_beta in CCR5 binding .
21403648	0	MIP-1a	23,29	CCL3	17,21	MIP-1a	CCL3	6348	6348	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for CCL3 -LRB- MIP-1a -RRB- in myeloma-induced bone_disease via osteocalcin downregulation and inhibition of osteoblast function .
21332278	0	MIP-1a	26,32	CXCL12	42,48	MIP-1a	CXCL12	25542(Tax:10116)	24772(Tax:10116)	Gene	Gene	Spatiotemporal|appos|START_ENTITY END_ENTITY|nsubj|Spatiotemporal	Spatiotemporal CCR1 , CCL3 -LRB- MIP-1a -RRB- , CXCR4 , CXCL12 -LRB- SDF-1a -RRB- expression patterns in a rat spinal_cord_injury model of posttraumatic neuropathic_pain .
26782821	0	MIP-1a	14,20	IL-17	0,5	MIP-1a	IL-17	20302(Tax:10090)	16171(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-17 induces MIP-1a expression in primary mouse astrocytes via TRPC channel .
24989845	0	MIP-1a	15,21	IL-17A	0,6	MIP-1a	IL-17A	20302(Tax:10090)	16171(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	IL-17A Induces MIP-1a Expression in Primary Astrocytes via Src/MAPK/PI3K / NF-kB Pathways : Implications for Multiple_Sclerosis .
18811584	0	MIP-1alpha	99,109	CCL27	111,116	MIP-1alpha	CCL27	6348	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
15831559	0	MIP-1alpha	0,10	CCL3	11,15	MIP-1alpha	CCL3	20302(Tax:10090)	20302(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	MIP-1alpha -LSB- CCL3 -RSB- acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4 .
15730850	0	MIP-1alpha	0,10	CCR1	25,29	MIP-1alpha	CCR1	1230	1230	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|END_ENTITY	MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells .
18811584	0	MIP-1alpha	99,109	CCR4	125,129	MIP-1alpha	CCR4	6348	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	MIP-1alpha	99,109	CCR5	131,135	MIP-1alpha	CCR5	6348	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	MIP-1alpha	99,109	CXCR3	137,142	MIP-1alpha	CXCR3	6348	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
16849642	0	MIP-1alpha	0,10	FGFR3	44,49	MIP-1alpha	FGFR3	6348	2261	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MIP-1alpha -LRB- CCL3 -RRB- is a downstream target of FGFR3 and RAS-MAPK signaling in multiple_myeloma .
18811584	0	MIP-1alpha	99,109	IFN-beta	161,169	MIP-1alpha	IFN-beta	6348	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	MIP-1alpha	99,109	IP-10	118,123	MIP-1alpha	IP-10	6348	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	MIP-1alpha	99,109	PD1	144,147	MIP-1alpha	PD1	6348	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	MIP-1alpha	99,109	PDL2	149,153	MIP-1alpha	PDL2	6348	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
12771199	0	MIP-1alpha	40,50	RUNX1	63,68	MIP-1alpha	RUNX1	6348	861	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ .
11426325	0	MIP-1alpha	70,80	macrophage_inflammatory_protein-1_alpha	29,68	MIP-1alpha	macrophage inflammatory protein-1 alpha	6348	6348	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Novel polymorphisms in human macrophage_inflammatory_protein-1_alpha -LRB- MIP-1alpha -RRB- gene .
9528906	0	MIP-1alpha	107,117	monocyte_chemoattractant_protein-1	22,56	MIP-1alpha	monocyte chemoattractant protein-1	6348	6347	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Correlation of plasma monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and monocyte inflammatory protein-1alpha -LRB- MIP-1alpha -RRB- levels with disease activity and clinical course of sarcoidosis .
22810435	0	MIP-1b	97,103	TNF-a	90,95	MIP-1b	TNF-a	6351	7124	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Acute myocardial_infarction and cardiogenic_shock : prognostic impact of cytokines : INF-y , TNF-a , MIP-1b , G-CSF , and MCP-1b .
19620252	0	MIP-1beta	62,71	CCL4	72,76	MIP-1beta	CCL4	6351	6351	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta / CCL4 signaling and chemotaxis of primary human macrophages .
8658171	0	MIP-1beta	31,40	CC_CKR5	0,7	MIP-1beta	CC CKR5	6351	1234	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	CC_CKR5 : a RANTES , MIP-1alpha , MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 .
11972057	0	MIP-1beta	12,21	IFN-gamma	76,85	MIP-1beta	IFN-gamma	20303(Tax:10090)	15978(Tax:10090)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	MIP-1alpha , MIP-1beta , RANTES , and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines .
9038318	0	MIP-1beta	204,213	IL-1beta	63,71	MIP-1beta	IL-1beta	20303(Tax:10090)	16176(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of mannose receptor in cytokine interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , and granulocyte-macrophage_colony-stimulating_factor responses , but not in chemokine macrophage_inflammatory_protein_1beta -LRB- MIP-1beta -RRB- , MIP-2 , and KC responses , caused by attachment of Candida_albicans to macrophages .
12445801	0	MIP-1beta	46,55	RANTES	64,70	MIP-1beta	RANTES	6351	6352	Gene	Gene	IP-10|dep|START_ENTITY MCP-1|dep|IP-10 MCP-1|dep|END_ENTITY	The presence of chemokine -LRB- MCP-1 , MIP-1alpha , MIP-1beta , IP-10 , RANTES -RRB- - positive cells and chemokine_receptor -LRB- CCR5 , CXCR3 -RRB- - positive cells in inflamed human gingival tissues .
8658171	0	MIP-1beta	31,40	RANTES	11,17	MIP-1beta	RANTES	6351	6352	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	CC_CKR5 : a RANTES , MIP-1alpha , MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 .
12381680	0	MIP-1beta	157,166	hCCR1	137,142	MIP-1beta	hCCR1	6351	1230	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Pharmacological characterization of the chemokine_receptor , hCCR1 in a stable transfectant and differentiated HL-60 cells : antagonism of hCCR1 activation by MIP-1beta .
12381680	0	MIP-1beta	157,166	hCCR1	60,65	MIP-1beta	hCCR1	6351	1230	Gene	Gene	activation|nmod|START_ENTITY antagonism|nmod|activation characterization|dep|antagonism characterization|nmod|chemokine_receptor chemokine_receptor|appos|END_ENTITY	Pharmacological characterization of the chemokine_receptor , hCCR1 in a stable transfectant and differentiated HL-60 cells : antagonism of hCCR1 activation by MIP-1beta .
17130903	0	MIP-2	16,21	CXCL2	23,28	MIP-2	CXCL2	20310(Tax:10090)	20310(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Upregulation of MIP-2 -LRB- CXCL2 -RRB- expression by 15-deoxy-Delta -LRB- 12,14 -RRB- - prostaglandin_J -LRB- 2 -RRB- in mouse peritoneal macrophages .
9038318	0	MIP-2	216,221	IL-1beta	63,71	MIP-2	IL-1beta	20310(Tax:10090)	16176(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of mannose receptor in cytokine interleukin-1beta -LRB- IL-1beta -RRB- , IL-6 , and granulocyte-macrophage_colony-stimulating_factor responses , but not in chemokine macrophage_inflammatory_protein_1beta -LRB- MIP-1beta -RRB- , MIP-2 , and KC responses , caused by attachment of Candida_albicans to macrophages .
26502930	0	MIP-2	78,83	MMP-9	102,107	MIP-2	MMP-9	114105(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Effect of rutin on spinal_cord_injury through inhibition of the expression of MIP-2 and activation of MMP-9 , and downregulation of Akt phosphorylation .
17662312	0	MIP-2	0,5	RhoA	40,44	MIP-2	RhoA	20310(Tax:10090)	11848(Tax:10090)	Gene	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	MIP-2 causes differential activation of RhoA in mouse aortic versus pulmonary artery endothelial cells .
11591793	0	MIP-2	62,67	macrophage-inflammatory_protein_2	27,60	MIP-2	macrophage-inflammatory protein 2	20310(Tax:10090)	20310(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Constitutive expression of macrophage-inflammatory_protein_2 -LRB- MIP-2 -RRB- mRNA in bone marrow gives rise to peripheral neutrophils with preformed MIP-2 protein .
21142721	0	MIP-2	97,102	macrophage_inflammatory_protein-2	62,95	MIP-2	macrophage inflammatory protein-2	114105(Tax:10116)	114105(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Low-level laser therapy associated to N-acetylcysteine lowers macrophage_inflammatory_protein-2 -LRB- MIP-2 -RRB- mRNA expression and generation of intracellular reactive oxygen species in alveolar macrophages .
11152502	0	MIP-2	58,63	macrophage_inflammatory_protein_2	23,56	MIP-2	macrophage inflammatory protein 2	20310(Tax:10090)	20310(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Enhanced production of macrophage_inflammatory_protein_2 -LRB- MIP-2 -RRB- by in vitro and in vivo infections with encephalomyocarditis_virus and modulation of myocarditis with an antibody against MIP-2 .
11994140	0	MIP-3_alpha	32,43	CCL20	44,49	MIP-3 alpha	CCL20	6364	6364	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dep|Expression	Expression of the C-C chemokine MIP-3_alpha / CCL20 in human epidermis with impaired permeability barrier function .
12414801	0	MIP-3alpha	66,76	ESE-1	0,5	MIP-3alpha	ESE-1	6364	1999	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ESE-1 , an enterocyte-specific Ets transcription factor , regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells .
9893054	0	MIP-3alpha	0,10	MIP-3beta	12,21	MIP-3alpha	MIP-3beta	6364	6363	Gene	Gene	induce|advmod|START_ENTITY induce|nsubj|END_ENTITY	MIP-3alpha , MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium , and activate the heterotrimeric G proteins in human natural killer cells .
9223454	0	MIP-3alpha	42,52	STRL22	0,6	MIP-3alpha	STRL22	6364	1235	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	STRL22 is a receptor for the CC chemokine MIP-3alpha .
9893054	0	MIP-3beta	12,21	MIP-3alpha	0,10	MIP-3beta	MIP-3alpha	6363	6364	Gene	Gene	induce|nsubj|START_ENTITY induce|advmod|END_ENTITY	MIP-3alpha , MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium , and activate the heterotrimeric G proteins in human natural killer cells .
1790714	0	MIP26	78,83	Calmodulin	0,10	MIP26	Calmodulin	4284	808	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26 .
2487274	0	MIP26	76,81	Calmodulin	0,10	MIP26	Calmodulin	4284	808	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26 .
3286127	0	MIP26	51,56	main_intrinsic_polypeptide	23,49	MIP26	main intrinsic polypeptide	4284	4284	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Proteolytic changes in main_intrinsic_polypeptide -LRB- MIP26 -RRB- from membranes in selenite cataract .
21971746	0	MIPS	76,80	Myo-inositol-1-phosphate_synthase	41,74	MIPS	Myo-inositol-1-phosphate synthase	542841(Tax:4565)	542841(Tax:4565)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression analysis of a heat-inducible , Myo-inositol-1-phosphate_synthase -LRB- MIPS -RRB- gene from wheat and the alternatively spliced variants of rice and Arabidopsis .
24942805	0	MIR-23a	96,103	p53	35,38	MIR-23a	p53	407010	7157	Gene	Gene	network|nmod|START_ENTITY involved|nmod|network gets|xcomp|involved gets|nsubj|suppressor suppressor|dep|up-regulation up-regulation|compound|END_ENTITY	Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular_carcinoma .
12582153	0	MIR1	84,88	c-MIR	0,5	MIR1	c-MIR	79187	220972	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	c-MIR , a human E3_ubiquitin_ligase , is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity .
25217366	0	MIR137	38,44	TCF4	46,50	MIR137	TCF4	406928	6925	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	No effect of schizophrenia risk genes MIR137 , TCF4 , and ZNF804A on macroscopic brain structure .
24275578	0	MIR137	0,6	miR-137	39,46	MIR137	miR-137	406928	406928	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese .
24726732	0	MIR146A	0,7	JMJD3	17,22	MIR146A	JMJD3	406938	23135	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	MIR146A inhibits JMJD3 expression and osteogenic differentiation in human mesenchymal stem cells .
10760272	0	MIR16	0,5	RGS16	83,88	MIR16	RGS16	51573	6004	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MIR16 , a putative membrane glycerophosphodiester phosphodiesterase , interacts with RGS16 .
21496004	0	MIR29B	0,6	MLLT11	31,37	MIR29B	MLLT11	407024	10962	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MIR29B regulates expression of MLLT11 -LRB- AF1Q -RRB- , an MLL fusion partner , and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML .
25908244	0	MIR31HG	11,18	p16	29,32	MIR31HG	p16	554202	1029	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The lncRNA MIR31HG regulates p16 -LRB- INK4A -RRB- expression to modulate senescence .
24418846	0	MIR34A	0,6	HMGB1	54,59	MIR34A	HMGB1	407040	3146	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell .
19056816	0	MIS	111,114	Mullerian-inhibiting_substance	79,109	MIS	Mullerian-inhibiting substance	268	268	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Interaction of the vitamin_D_receptor with a vitamin_D response element in the Mullerian-inhibiting_substance -LRB- MIS -RRB- promoter : regulation of MIS expression by calcitriol in prostate_cancer cells .
20599950	0	MIST1	0,5	Atp2c2	57,63	MIST1	Atp2c2	17341(Tax:10090)	69047(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MIST1 regulates the pancreatic acinar cell expression of Atp2c2 , the gene encoding secretory pathway calcium ATPase 2 .
20038531	0	MIST1	54,59	RAB26	0,5	MIST1	RAB26	168620	25837	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation .
21203491	0	MITF	30,34	ATF2	11,15	MITF	ATF2	17342(Tax:10090)	11909(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for ATF2 in regulating MITF and melanoma development .
18628967	0	MITF	84,88	BRAF	10,14	MITF	BRAF	4286	673	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF .
20596077	0	MITF	57,61	CXCL1	33,38	MITF	CXCL1	4286	2919	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth .
23261059	0	MITF	94,98	ERK	159,162	MITF	ERK	17342(Tax:10090)	26413(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Caffeoylserotonin on inhibition of melanogenesis through the downregulation of MITF via the reduction of intracellular cAMP and acceleration of ERK activation in B16 murine melanoma cells .
26263195	0	MITF	107,111	ERK	83,86	MITF	ERK	4286	5594	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	Inhibitory effects of N,N,N-trimethyl _ phytosphingosine-iodide on melanogenesis via ERK activation-mediated MITF degradation .
26262610	0	MITF	77,81	Erk1/2	61,67	MITF	Erk1/2	4286	5595;5594	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Hesperidin , A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation .
24390218	0	MITF	46,50	FN1	37,40	MITF	FN1	4286	2335	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	A novel hypoxia-associated subset of FN1 high MITF low melanoma cells : identification , characterization , and prognostic value .
19403660	0	MITF	108,112	FOXD3	0,5	MITF	FOXD3	17342(Tax:10090)	15221(Tax:10090)	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism .
25889792	0	MITF	25,29	GPNMB	57,62	MITF	GPNMB	4286	10457	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells .
25889792	0	MITF	25,29	GPNMB	57,62	MITF	GPNMB	4286	10457	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells .
22647378	0	MITF	37,41	HINT1	21,26	MITF	HINT1	4286	3094	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The tumor suppressor HINT1 regulates MITF and b-catenin transcriptional activity in melanoma cells .
25648896	0	MITF	84,88	HINT1	129,134	MITF	HINT1	4286	3094	Gene	Gene	activity|nmod|START_ENTITY induces|dobj|activity induces|nmod|END_ENTITY	The intracellular_domain of teneurin-1 induces the activity of transcription factor MITF by binding to transcriptional repressor HINT1 .
25584612	0	MITF	192,196	Microphthalmia-Associated_Transcription_Factor	144,190	MITF	Microphthalmia-Associated Transcription Factor	17342(Tax:10090)	17342(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Hair Dyes Resorcinol and Lawsone Reduce Production of Melanin in Melanoma Cells by Tyrosinase Activity Inhibition and Decreasing Tyrosinase and Microphthalmia-Associated_Transcription_Factor -LRB- MITF -RRB- Expression .
18444964	0	MITF	21,25	PPAR_gamma	0,10	MITF	PPAR gamma	17342(Tax:10090)	19016(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PPAR_gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91 .
10982026	0	MITF	70,74	SOX10	89,94	MITF	SOX10	4286	6663	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcription factor hierarchy in Waardenburg_syndrome : regulation of MITF expression by SOX10 and PAX3 .
14744763	0	MITF	83,87	TRPM1	73,78	MITF	TRPM1	4286	4308	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of the melanoma prognostic marker melastatin -LRB- TRPM1 -RRB- by MITF in melanocytes and melanoma .
26301891	0	MITF	0,4	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	36,93	MITF	carcinoembryonic antigen-related cell adhesion molecule 1	4286	634	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MITF is a critical regulator of the carcinoembryonic_antigen-related_cell_adhesion_molecule_1 -LRB- CEACAM1 -RRB- in malignant_melanoma .
15892717	0	MITF	67,71	dopachrome_tautomerase	32,54	MITF	dopachrome tautomerase	4286	1638	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Dynamic regulation of the human dopachrome_tautomerase promoter by MITF , ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes .
15577322	0	MITF	43,47	melastatin_1	6,18	MITF	melastatin 1	4286	4308	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Human melastatin_1 -LRB- TRPM1 -RRB- is regulated by MITF and produces multiple polypeptide isoforms in melanocytes and melanoma .
10694430	0	MITF	61,65	microphthalmia-associated_transcription_factor	14,60	MITF	microphthalmia-associated transcription factor	4286	4286	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of microphthalmia-associated_transcription_factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9 .
25414259	0	MITF	85,89	microphthalmia-associated_transcription_factor	37,83	MITF	microphthalmia-associated transcription factor	4286	4286	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	MicroRNA-340-mediated degradation of microphthalmia-associated_transcription_factor -LRB- MITF -RRB- mRNA is inhibited by coding_region_determinant-binding_protein -LRB- CRD-BP -RRB- .
16411896	0	MITF	0,4	protein_kinase_C-beta	27,48	MITF	protein kinase C-beta	4286	5579	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	MITF mediates cAMP-induced protein_kinase_C-beta expression in human melanocytes .
11741327	0	MITF	10,14	transmembrane_tryptase	35,57	MITF	transmembrane tryptase	17342(Tax:10090)	26945(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|gene gene|amod|END_ENTITY	Effect of MITF on transcription of transmembrane_tryptase gene in cultured mast cells of mice .
24445257	0	MITF	171,175	tyrosinase	108,118	MITF	tyrosinase	17342(Tax:10090)	22173(Tax:10090)	Gene	Gene	expressions|appos|START_ENTITY expressions|amod|END_ENTITY	Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor -LRB- MITF -RRB- expressions and the activation of caspase-3 , _ -8 _ and _ -9 .
15950311	0	MIZIP	36,41	Melanin-concentrating_hormone_receptor_1	73,113	MIZIP	Melanin-concentrating hormone receptor 1	116225	2847	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating_hormone_receptor_1 in the adult rodent brain .
20410075	0	MJ1434	28,34	TTC0482	91,98	MJ1434	TTC0482	1452338(Tax:243232)	2776011(Tax:262724)	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Helix-hairpin-helix protein MJ1434 from Methanocaldococcus_jannaschii and EndoIV homologue TTC0482 from Thermus_thermophilus_HB27 do not process DNA uracil residues .
15233999	0	MJD	121,124	Machado-Joseph_disease	97,119	MJD	Machado-Joseph disease	110616(Tax:10090)	110616(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure , promoter activity , and developmental expression of the mouse homologue of the Machado-Joseph_disease -LRB- MJD -RRB- gene .
18160752	0	MJD	21,24	SCA_2	7,12	MJD	SCA 2	4287	6311	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	SCA_1 , SCA_2 _ SCA_3 / MJD mutations in ataxia_syndromes in southern India .
18160752	0	MJD	21,24	SCA_3	15,20	MJD	SCA 3	4287	4287	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	SCA_1 , SCA_2 _ SCA_3 / MJD mutations in ataxia_syndromes in southern India .
8537330	0	MK	9,11	Midkine	0,7	MK	Midkine	17242(Tax:10090)	17242(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Midkine -LRB- MK -RRB- expression in extraembryonic tissues , amniotic fluid , and cerebrospinal fluid during mouse embryogenesis .
25165473	0	MK-0431	50,57	Dipeptidyl_Peptidase-4	11,33	MK-0431	Dipeptidyl Peptidase-4	1477734(Tax:190192)	13482(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|compound|END_ENTITY	Effects of Dipeptidyl_Peptidase-4 Inhibition with MK-0431 on Syngeneic Mouse Islet Transplantation .
17244767	0	MK-0431	89,96	dipeptidyl_peptidase-4	101,123	MK-0431	dipeptidyl peptidase-4	1477734(Tax:190192)	1803	Gene	Gene	pharmacokinetics|appos|START_ENTITY pharmacokinetics|appos|inhibitor inhibitor|amod|END_ENTITY	Effect of a single cyclosporine dose on the single-dose pharmacokinetics of sitagliptin -LRB- MK-0431 -RRB- , a dipeptidyl_peptidase-4 inhibitor , in healthy male subjects .
8039530	0	MK-0434	82,89	5_alpha-reductase	101,118	MK-0434	5 alpha-reductase	1477737(Tax:190192)	6715	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434 , a steroid 5_alpha-reductase inhibitor , in healthy subjects .
25127392	0	MK-0457	19,26	BCR-ABL	44,51	MK-0457	BCR-ABL	1477760(Tax:190192)	25	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic_myelogenous_leukemia and philadelphia_chromosome-positive_acute_lymphoblastic_leukemia .
2545579	0	MK-0521	54,61	Angiotensin_converting_enzyme	1,30	MK-0521	Angiotensin converting enzyme	1476622(Tax:190192)	610668(Tax:9615)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	-LSB- Angiotensin_converting_enzyme inhibitory activity of MK-0521 in vivo and antihypertensive effect of its single oral administration on blood pressure and effect on the renin-angiotensin system in 2-kidney Goldblatt hypertensive dogs -RSB- .
2545578	0	MK-0521	80,87	angiotensin_converting_enzyme	92,121	MK-0521	angiotensin converting enzyme	1476622(Tax:190192)	24310(Tax:10116)	Gene	Gene	L-lysyl-L-proline|appos|START_ENTITY L-lysyl-L-proline|nmod|END_ENTITY	-LSB- Inhibitory effect of N-alpha - -LSB- -LRB- S -RRB- -1 - carboxy-3-phenylpropyl -RSB- - L-lysyl-L-proline -LRB- MK-0521 -RRB- on angiotensin_converting_enzyme in vitro -RSB- .
7822663	0	MK-0591	14,21	5-lipoxygenase	31,45	MK-0591	5-lipoxygenase	1476692(Tax:190192)	240	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The effect of MK-0591 , a novel 5-lipoxygenase activating protein inhibitor , on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo .
25473177	0	MK-0626	0,7	DPP-4	21,26	MK-0626	DPP-4	1476727(Tax:190192)	13482(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MK-0626 , a selective DPP-4 inhibitor , attenuates hepatic_steatosis in ob/ob mice .
24059225	0	MK-0626	0,7	dipeptidyl_peptidase-4	11,33	MK-0626	dipeptidyl peptidase-4	1476727(Tax:190192)	13482(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK-0626 , a dipeptidyl_peptidase-4 inhibitor , improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric_oxide synthetase expression .
20970976	0	MK-0633	0,7	5-lipoxygenase	18,32	MK-0633	5-lipoxygenase	1476734(Tax:190192)	240	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK-0633 , a potent 5-lipoxygenase inhibitor , in chronic_obstructive_pulmonary_disease .
21945511	0	MK-0633	33,40	5-lipoxygenase	44,58	MK-0633	5-lipoxygenase	1476734(Tax:190192)	240	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The efficacy and tolerability of MK-0633 , a 5-lipoxygenase inhibitor , in chronic_asthma .
20061146	0	MK-0674	17,24	cathepsin_K	49,60	MK-0674	cathepsin K	1476775(Tax:190192)	1513	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	The discovery of MK-0674 , an orally bioavailable cathepsin_K inhibitor .
17303970	0	MK-0703	0,7	cyclooxygenase-2	11,27	MK-0703	cyclooxygenase-2	1476804(Tax:190192)	5743	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	MK-0703 -LRB- a cyclooxygenase-2 inhibitor -RRB- in acute pain associated with dental surgery : a randomized , double-blind , placebo - and active comparator-controlled dose-ranging study .
18321743	0	MK-0873	0,7	PDE4	11,15	MK-0873	PDE4	1476974(Tax:190192)	5141	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	MK-0873 , a PDE4 inhibitor , does not influence the pharmacokinetics of theophylline in healthy male volunteers .
18835163	0	MK-0873	130,137	PDE4	162,166	MK-0873	PDE4	1476974(Tax:190192)	5141	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Optimization and structure-activity relationship of a series of 1-phenyl-1 ,8 - naphthyridin-4-one-3-carboxamides : identification of MK-0873 , a potent and effective PDE4 inhibitor .
25523287	0	MK-0888	76,83	FLT-3	95,100	MK-0888	FLT-3	1476989(Tax:190192)	2322	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888 , a VEGFR-2 / FLT-3 kinase inhibitor .
25523287	0	MK-0888	76,83	VEGFR-2	87,94	MK-0888	VEGFR-2	1476989(Tax:190192)	3791	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888 , a VEGFR-2 / FLT-3 kinase inhibitor .
23238431	0	MK-0911	22,29	ORL1	103,107	MK-0911	ORL1	1477012(Tax:190192)	4987	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of -LSB- F -RSB- MK-0911 , a positron emission tomography -LRB- PET -RRB- tracer for opioid receptor-like 1 -LRB- ORL1 -RRB- , in rhesus_monkey and human .
8299317	0	MK-0963	20,27	5_alpha-reductase	35,52	MK-0963	5 alpha-reductase	1477064(Tax:190192)	6715	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacodynamics of MK-0963 , a new 5_alpha-reductase inhibitor : effects on serum androgen concentrations .
18811135	0	MK-1256	72,79	cathepsin_K	49,60	MK-1256	cathepsin K	1477851(Tax:190192)	1513	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Identification of a nonbasic , nitrile-containing cathepsin_K inhibitor -LRB- MK-1256 -RRB- that is efficacious in a monkey model of osteoporosis .
20180778	0	MK-STYX	22,29	G3BP	45,49	MK-STYX	G3BP	51657	10146	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation .
19073764	0	MK0431	40,46	Dipeptidyl_peptidase_IV	0,23	MK0431	Dipeptidyl peptidase IV	1477734(Tax:190192)	13482(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Dipeptidyl_peptidase_IV inhibition with MK0431 improves islet graft survival in diabetic_NOD mice partially via T-cell modulation .
18299314	0	MK0431	56,62	dipeptidyl_peptidase_IV	14,37	MK0431	dipeptidyl peptidase IV	1477734(Tax:190192)	13482(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV with sitagliptin -LRB- MK0431 -RRB- prolongs islet graft survival in streptozotocin-induced diabetic mice .
20368408	0	MK0431	13,19	dipeptidyl_peptidase_IV	35,58	MK0431	dipeptidyl peptidase IV	1477734(Tax:190192)	13482(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Sitagliptin -LRB- MK0431 -RRB- inhibition of dipeptidyl_peptidase_IV decreases nonobese diabetic mouse CD4 + T-cell migration through incretin-dependent and - independent pathways .
20501446	0	MK2	36,39	HSP60	14,19	MK2	HSP60	17164(Tax:10090)	15510(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis .
22268119	0	MK2	0,3	ICAM-1	64,70	MK2	ICAM-1	9261	3383	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MK2 posttranscriptionally regulates TNF-a-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascular endothelial cells .
24020373	0	MK2	93,96	Ube2j1	62,68	MK2	Ube2j1	9261	51465	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 -LRB- MAPKAP_kinase-2 -RRB- involved in MK2-mediated TNFa production .
21873449	0	MK2	105,108	p38_MAPK	96,104	MK2	p38 MAPK	17164(Tax:10090)	26416(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38_MAPK / MK2 pathway .
21586572	0	MK2	107,110	signal_transducers_and_activators_of_transcription_3	147,199	MK2	signal transducers and activators of transcription 3	9261	6774	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Distinct functions of the mitogen-activated protein kinase-activated protein -LRB- MAPKAP -RRB- kinases MK2 and MK3 : MK2 mediates lipopolysaccharide-induced signal_transducers_and_activators_of_transcription_3 -LRB- STAT3 -RRB- activation by preventing negative regulatory effects of MK3 .
23878308	0	MK5	0,3	Foxo1	36,41	MK5	Foxo1	8550	2308	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	MK5 activates Rag transcription via Foxo1 in developing B cells .
9490724	0	MKBP	0,4	myotonic_dystrophy_protein_kinase	85,118	MKBP	myotonic dystrophy protein kinase	3316	1760	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	MKBP , a novel member of the small heat_shock protein family , binds and activates the myotonic_dystrophy_protein_kinase .
16802349	0	MKK-7	21,26	JNK	14,17	MKK-7	JNK	5609	5599	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of JNK by MKK-7 in fibroblast-like synoviocytes .
9162092	1	MKK3	180,184	MEK_kinase_3	157,169	MKK3	MEK kinase 3	5606	4215	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	MEK_kinase_3 activates MKK3 but does not cause activation of p38 kinase in vivo .
19427893	0	MKK3	0,4	p38	31,34	MKK3	p38	26397(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	MKK3 , an upstream activator of p38 , contributes to formalin phase 2 and late allodynia in mice .
17187786	0	MKK4	28,32	JNK	45,48	MKK4	JNK	6416	5599	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|END_ENTITY	Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins .
21333379	0	MKK4	77,81	JNK	18,21	MKK4	JNK	6416	5599	Gene	Gene	characteristics|nmod|START_ENTITY bottleneck|dep|characteristics bottleneck|nmod|signaling signaling|compound|END_ENTITY	The bottleneck of JNK signaling : molecular and functional characteristics of MKK4 and MKK7 .
25244576	0	MKK4	150,154	JNK	76,79	MKK4	JNK	6416	5599	Gene	Gene	protein|nmod|START_ENTITY affinity|dep|protein affinity|appos|END_ENTITY	Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase -LRB- JNK -RRB- - interacting protein 4 for mitogen-activated_protein_kinase_kinase_4 -LRB- MKK4 -RRB- and suppresses the phosphorylation of MKK4 , p38 , and JNK , thereby inhibiting apoptosis .
25244576	0	MKK4	194,198	JNK	76,79	MKK4	JNK	6416	5599	Gene	Gene	affinity|nmod|START_ENTITY affinity|appos|END_ENTITY	Knockdown of Sec8 enhances the binding affinity of c-Jun N-terminal kinase -LRB- JNK -RRB- - interacting protein 4 for mitogen-activated_protein_kinase_kinase_4 -LRB- MKK4 -RRB- and suppresses the phosphorylation of MKK4 , p38 , and JNK , thereby inhibiting apoptosis .
10715136	0	MKK4	41,45	JNK3_alpha	108,118	MKK4	JNK3 alpha	6416	5602	Gene	Gene	START_ENTITY|dep|characterization characterization|nmod|END_ENTITY	Activation of JNK3_alpha 1 requires both MKK4 and MKK7 : kinetic characterization of in vitro phosphorylated JNK3_alpha 1 .
10715136	0	MKK4	41,45	JNK3_alpha	14,24	MKK4	JNK3 alpha	6416	5602	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of JNK3_alpha 1 requires both MKK4 and MKK7 : kinetic characterization of in vitro phosphorylated JNK3_alpha 1 .
16805806	0	MKK4	91,95	mitogen-activated_protein_kinase_kinase_4	48,89	MKK4	mitogen-activated protein kinase kinase 4	287398(Tax:10116)	287398(Tax:10116)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Blockade of the translocation and activation of mitogen-activated_protein_kinase_kinase_4 -LRB- MKK4 -RRB- signaling attenuates neuronal_damage during later ischemia-reperfusion .
26554816	0	MKL1	41,45	Filamin_A	0,9	MKL1	Filamin A	57591	2316	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Filamin_A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration .
18036521	0	MKL1	73,77	SPT16	62,67	MKL1	SPT16	57591	11198	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of SRF-dependent gene expression by association of SPT16 with MKL1 .
25888165	0	MKL1	0,4	p21	45,48	MKL1	p21	223701(Tax:10090)	12575(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MKL1 inhibits cell cycle progression through p21 in podocytes .
25888165	0	MKL1	0,4	p21	45,48	MKL1	p21	223701(Tax:10090)	12575(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MKL1 inhibits cell cycle progression through p21 in podocytes .
10640805	0	MKLN1	65,70	muskelin	22,30	MKLN1	muskelin	4289	4289	Gene	Gene	gene|appos|START_ENTITY END_ENTITY|nmod|gene	cDNA cloning of human muskelin and localisation of the muskelin -LRB- MKLN1 -RRB- gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH .
10640805	0	MKLN1	65,70	muskelin	55,63	MKLN1	muskelin	4289	4289	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	cDNA cloning of human muskelin and localisation of the muskelin -LRB- MKLN1 -RRB- gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH .
22249268	0	MKNK1	0,5	YB-1	11,15	MKNK1	YB-1	8569	4904	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition .
8550616	0	MKP-1	53,58	Atrial_natriuretic_peptide	0,26	MKP-1	Atrial natriuretic peptide	114856(Tax:10116)	24602(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Atrial_natriuretic_peptide induces the expression of MKP-1 , a mitogen-activated protein kinase phosphatase , in glomerular mesangial cells .
26829212	0	MKP-1	82,87	BRAF	51,55	MKP-1	BRAF	1843	673	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1 .
11878930	0	MKP-1	143,148	ERK	72,75	MKP-1	ERK	1843	5594	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	Hepatitis_C_virus core protein induces cell proliferation and activates ERK , JNK , and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line .
16286470	0	MKP-1	35,40	ERK	15,18	MKP-1	ERK	1843	5594	Gene	Gene	destruction|compound|START_ENTITY Cooperation|nmod|destruction Cooperation|nmod|END_ENTITY	Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling .
18824214	0	MKP-1	123,128	ERK	53,56	MKP-1	ERK	114856(Tax:10116)	24338(Tax:10116)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|extracellular_signal-regulated_kinase extracellular_signal-regulated_kinase|appos|END_ENTITY	Activation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and induction of mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP-1 -RRB- by perifused thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation in rat pituitary GH3 cells .
21059338	0	MKP-1	135,140	ERK	120,123	MKP-1	ERK	1843	5594	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor , MKP-1 .
21840882	0	MKP-1	102,107	ERK	80,83	MKP-1	ERK	1843	5594	Gene	Gene	induction|compound|START_ENTITY END_ENTITY|nmod|induction	Tauroursodeoxycholate -LRB- TUDCA -RRB- inhibits neointimal hyperplasia by suppression of ERK via PKCa-mediated MKP-1 induction .
22573375	0	MKP-1	93,98	ERK	77,80	MKP-1	ERK	1843	5594	Gene	Gene	inducing|dobj|START_ENTITY upregulates|advcl|inducing upregulates|nmod|suppression suppression|nmod|END_ENTITY	Hypotonic stress upregulates b - and y-ENaC expression through suppression of ERK by inducing MKP-1 .
18434324	0	MKP-1	133,138	Erk1/2	103,109	MKP-1	Erk1/2	1843	5595;5594	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Phosphorylation of protein_kinase_Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1 : role in the apoptotic effect of etoposide .
15269202	0	MKP-1	28,33	MAPK_phosphatase-1	8,26	MKP-1	MAPK phosphatase-1	1843	1843	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of MAPK_phosphatase-1 -LRB- MKP-1 -RRB- in adipocyte differentiation .
21558315	0	MKP-1	20,25	MAPK_phosphatase-1	0,18	MKP-1	MAPK phosphatase-1	1843	1843	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MAPK_phosphatase-1 -LRB- MKP-1 -RRB- expression is up-regulated by hCG/cAMP and modulates steroidogenesis in MA-10 Leydig cells .
11055544	0	MKP-1	135,140	MAP_kinase_phosphatase-1	109,133	MKP-1	MAP kinase phosphatase-1	1843	1843	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Substitution of two insulin receptor carboxy-terminal tyrosines with phenylalanine impairs the expression of MAP_kinase_phosphatase-1 -LRB- MKP-1 -RRB- mRNA .
10212278	0	MKP-1	48,53	Mitogen-activated_protein_kinase_phosphatase-1	0,46	MKP-1	Mitogen-activated protein kinase phosphatase-1	1843	1843	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- expression is induced by low oxygen conditions found in solid tumor microenvironments .
20920579	0	MKP-1	14,19	PARP-1	128,134	MKP-1	PARP-1	1843	142	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|dep|mechanism mechanism|nmod|effect effect|nmod|activation activation|compound|END_ENTITY	Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress : a new mechanism for the cytoplasmic effect of PARP-1 activation .
20920579	0	MKP-1	14,19	PARP-1	54,60	MKP-1	PARP-1	1843	142	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress : a new mechanism for the cytoplasmic effect of PARP-1 activation .
23449457	0	MKP-1	43,48	TGF-b1	0,6	MKP-1	TGF-b1	1843	7040	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	TGF-b1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death .
19289102	0	MKP-1	72,77	TRH	113,116	MKP-1	TRH	114856(Tax:10116)	25569(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Possible involvement of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced prolactin gene expression .
18003751	0	MKP-1	25,30	VEGF	0,4	MKP-1	VEGF	1843	7422	Gene	Gene	pathways|xcomp|START_ENTITY pathways|nsubj|END_ENTITY	VEGF and thrombin induce MKP-1 through distinct signaling pathways : role for MKP-1 in endothelial cell migration .
24552656	0	MKP-1	84,89	cyclooxygenase-2	52,68	MKP-1	cyclooxygenase-2	19252(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Valproic_acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells .
18824214	0	MKP-1	123,128	extracellular_signal-regulated_kinase	14,51	MKP-1	extracellular signal-regulated kinase	114856(Tax:10116)	24338(Tax:10116)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and induction of mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP-1 -RRB- by perifused thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation in rat pituitary GH3 cells .
12432554	0	MKP-1	62,67	mitogen-activated_protein_kinase_phosphatase-1	14,60	MKP-1	mitogen-activated protein kinase phosphatase-1	1843	1843	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in primary human ovarian_carcinoma .
17647144	0	MKP-1	70,75	mitogen-activated_protein_kinase_phosphatase-1	22,68	MKP-1	mitogen-activated protein kinase phosphatase-1	114856(Tax:10116)	114856(Tax:10116)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Expression changes of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in myocardium of streptozotocin-induced diabetic rats .
22333693	0	MKP-1	52,57	mitogen-activated_protein_kinase_phosphatase-1	4,50	MKP-1	mitogen-activated protein kinase phosphatase-1	1843	1843	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- gene is a potential methylation biomarker for malignancy of breast_cancer .
8900190	0	MKP-1	111,116	mitogen-activated_protein_kinase_phosphatase-1	63,109	MKP-1	mitogen-activated protein kinase phosphatase-1	1843	1843	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The selective protein_kinase_C inhibitor , Ro-31-8220 , inhibits mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- expression , induces c-Jun expression , and activates Jun_N-terminal_kinase .
23533638	0	MKP-1	112,117	mitogen-activated_protein_kinase_phosphatase_1	64,110	MKP-1	mitogen-activated protein kinase phosphatase 1	1843	1843	Gene	Gene	increase|appos|START_ENTITY increase|amod|END_ENTITY	Long-acting b2-agonists increase fluticasone_propionate-induced mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP-1 -RRB- in airway_smooth_muscle cells .
18573614	0	MKP-1	29,34	p38	85,88	MKP-1	p38	114856(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Cadmium specifically induces MKP-1 expression via the glutathione depletion-mediated p38 MAPK activation in C6 glioma cells .
21084841	0	MKP-2	81,86	ERK	91,94	MKP-2	ERK	1846	5594	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Post-translational regulation of mitogen-activated_protein_kinase_phosphatase-2 -LRB- MKP-2 -RRB- by ERK .
21084841	0	MKP-2	81,86	mitogen-activated_protein_kinase_phosphatase-2	33,79	MKP-2	mitogen-activated protein kinase phosphatase-2	1846	1846	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Post-translational regulation of mitogen-activated_protein_kinase_phosphatase-2 -LRB- MKP-2 -RRB- by ERK .
15033693	0	MKP-3	25,30	ERK	45,48	MKP-3	ERK	40081(Tax:7227)	3354888(Tax:7227)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Drosophila MKP-3 by Drosophila ERK .
11239467	0	MKP-3	62,67	ERK2	114,118	MKP-3	ERK2	1848	5594	Gene	Gene	domain|nmod|START_ENTITY structure|nmod|domain structure|dep|insights insights|nmod|activation activation|nmod|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
11239467	0	MKP-3	62,67	ERK2	22,26	MKP-3	ERK2	1848	5594	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
11239467	0	MKP-3	94,99	ERK2	114,118	MKP-3	ERK2	1848	5594	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
11239467	0	MKP-3	94,99	ERK2	22,26	MKP-3	ERK2	1848	5594	Gene	Gene	activation|compound|START_ENTITY insights|nmod|activation structure|dep|insights structure|nmod|domain domain|compound|END_ENTITY	Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3 : structural insights into MKP-3 activation by ERK2 .
9596579	0	MKP-3	40,45	ERK2	49,53	MKP-3	ERK2	1848	5594	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase .
22848439	0	MKP-3	8,13	FOXO1	14,19	MKP-3	FOXO1	67603(Tax:10090)	56458(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|interaction interaction|nsubj|END_ENTITY	Mapping MKP-3 / FOXO1 interaction and evaluating the effect on gluconeogenesis .
22182512	0	MKP-7	0,5	IRF-1	72,77	MKP-7	IRF-1	80824	3659	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
22182512	0	MKP-7	0,5	JNK	31,34	MKP-7	JNK	80824	5599	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
23280045	0	MKP-7	61,66	JNK	44,47	MKP-7	JNK	297682(Tax:10116)	116554(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	PI3K/Akt-independent negative regulation of JNK signaling by MKP-7 after cerebral_ischemia in rat hippocampus .
22182512	0	MKP-7	0,5	VCAM-1	46,52	MKP-7	VCAM-1	80824	7412	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
26807102	0	MKP1	59,63	mitogen-activated_protein_kinase_phosphatase_1	11,57	MKP1	mitogen-activated protein kinase phosphatase 1	1843	1843	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP1 -RRB- in neural cell development and survival .
12890671	0	MKP1	16,20	p53	52,55	MKP1	p53	1843	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation .
15611668	0	MKP1	35,39	p53	0,3	MKP1	p53	1843	7157	Gene	Gene	Transactivates|dobj|START_ENTITY Transactivates|nsubj|END_ENTITY	p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elements .
15611668	0	MKP1	35,39	p53	73,76	MKP1	p53	1843	7157	Gene	Gene	Transactivates|dobj|START_ENTITY Transactivates|nmod|END_ENTITY	p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elements .
22100392	0	MKP3	0,4	Akt	39,42	MKP3	Akt	67603(Tax:10090)	11651(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis .
14690430	0	MKP3	43,47	ERK	36,39	MKP3	ERK	1848	5594	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Intramolecular dephosphorylation of ERK by MKP3 .
23246965	0	MKP3	36,40	Erk	18,21	MKP3	Erk	1848	5594	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	/ \ Np63a regulates Erk signaling via MKP3 to inhibit cancer metastasis .
24602610	0	MKP3	109,113	Erk	47,50	MKP3	Erk	67603(Tax:10090)	26413(Tax:10090)	Gene	Gene	MAP_kinase_phosphatase_3|appos|START_ENTITY induction|nmod|MAP_kinase_phosphatase_3 kinase|nmod|induction kinase|nsubj|MAP MAP|compound|END_ENTITY	Constitutively active Ras negatively regulates Erk MAP kinase through induction of MAP_kinase_phosphatase_3 -LRB- MKP3 -RRB- in NIH3T3 cells .
12766772	0	MKP3	0,4	FGF8	39,43	MKP3	FGF8	67603(Tax:10090)	14179(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb .
9559664	0	MKP3	62,66	nerve_growth_factor	70,89	MKP3	nerve growth factor	116663(Tax:10116)	310738(Tax:10116)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Induction of the mitogen-activated protein kinase phosphatase MKP3 by nerve_growth_factor in differentiating PC12 .
26175221	0	MKRN3	43,48	makorin_ring-finger_protein-3	12,41	MKRN3	makorin ring-finger protein-3	7681	7681	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels in healthy men and in men with hypogonadotropic_hypogonadism .
26175221	0	MKRN3	43,48	makorin_ring-finger_protein-3	12,41	MKRN3	makorin ring-finger protein-3	7681	7681	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels in healthy men and in men with hypogonadotropic_hypogonadism .
26970436	0	MKRN3	43,48	makorin_ring-finger_protein-3	12,41	MKRN3	makorin ring-finger protein-3	7681	7681	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels in healthy men and in men with hypogonadotropic_hypogonadism .
27025240	0	MKRN3	43,48	makorin_ring-finger_protein-3	12,41	MKRN3	makorin ring-finger protein-3	7681	7681	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels decline in boys before the clinical onset of puberty .
26490104	0	MKS1	0,4	INPP5E	23,29	MKS1	INPP5E	54903	56623	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	MKS1 regulates ciliary INPP5E levels in Joubert_syndrome .
21149564	0	MKlp2	34,39	Mad2	0,4	MKlp2	Mad2	10112	4085	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Mad2 inhibits the mitotic kinesin MKlp2 .
8630096	0	ML-1	77,81	c-myb	52,57	ML-1	c-myb	112744	4602	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Induction of differentiation and down-regulation of c-myb gene expression in ML-1 human myeloblastic_leukemia cells by the clinically effective anti-leukemia agent meisoindigo .
10953004	0	MLC	70,73	MLCK	40,44	MLC	MLCK	23209	91807	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Distinct roles of ROCK -LRB- Rho-kinase -RRB- and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts .
12748065	0	MLC	84,87	Rho	30,33	MLC	Rho	23209	6010	Gene	Gene	phosphorylation|compound|START_ENTITY involvement|nmod|phosphorylation END_ENTITY|dep|involvement	Hyperosmotic stress activates Rho : differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation .
12748065	0	MLC	84,87	Rho	63,66	MLC	Rho	23209	6010	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Hyperosmotic stress activates Rho : differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation .
6180065	0	MLC	118,121	gamma-interferon	72,88	MLC	gamma-interferon	170790(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Characteristics of alloantigens and cellular mechanisms responsible for gamma-interferon production in primary murine MLC .
24100445	0	MLC	54,57	myosin_light_chain	34,52	MLC	myosin light chain	23209	23209	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	cAMP signaling regulates platelet myosin_light_chain -LRB- MLC -RRB- phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway .
22425609	0	MLC2	120,124	myosin_regulatory_light_chain	89,118	MLC2	myosin regulatory light chain	4633	4633	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Gene duplication and conversion events shaped three homologous , differentially expressed myosin_regulatory_light_chain -LRB- MLC2 -RRB- genes .
10953004	0	MLCK	40,44	MLC	70,73	MLCK	MLC	91807	23209	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Distinct roles of ROCK -LRB- Rho-kinase -RRB- and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts .
16571721	0	MLDP	0,4	peroxisome_proliferator-activated_receptor_alpha	104,152	MLDP	peroxisome proliferator-activated receptor alpha	66968(Tax:10090)	19013(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	MLDP , a novel PAT family protein localized to lipid droplets and enriched in the heart , is regulated by peroxisome_proliferator-activated_receptor_alpha .
25249451	0	MLH1	20,24	DCC	15,18	MLH1	DCC	4292	1630	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association of DCC , MLH1 , GSTT1 , GSTM1 , and TP53 gene polymorphisms with colorectal_cancer in Kazakhstan .
20708344	0	MLH1	88,92	GSTM1	68,73	MLH1	GSTM1	4292	2944	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	MLH1	88,92	GSTT1	75,80	MLH1	GSTT1	4292	2952	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
25249451	0	MLH1	20,24	GSTT1	26,31	MLH1	GSTT1	4292	2952	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association of DCC , MLH1 , GSTT1 , GSTM1 , and TP53 gene polymorphisms with colorectal_cancer in Kazakhstan .
10097147	0	MLH1	96,100	MED1	0,4	MLH1	MED1	4292	5469	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MED1 , a novel human methyl-CpG-binding endonuclease , interacts with DNA mismatch repair protein MLH1 .
10612836	0	MLH1	18,22	MSH2	11,15	MLH1	MSH2	4292	4436	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Four novel MSH2 / MLH1 gene mutations in portuguese HNPCC families .
11600610	0	MLH1	57,61	MSH2	0,4	MLH1	MSH2	4292	4436	Gene	Gene	carriers|compound|START_ENTITY risk|nmod|carriers risk|nsubj|carriers carriers|compound|END_ENTITY	MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers : a study of hereditary nonpolyposis colorectal_cancer families .
11830542	0	MLH1	20,24	MSH2	0,4	MLH1	MSH2	4292	4436	Gene	Gene	contrast|nmod|START_ENTITY END_ENTITY|nmod|contrast	MSH2 in contrast to MLH1 and MSH6 is frequently inactivated by exonic and promoter rearrangements in hereditary_nonpolyposis_colorectal_cancer .
15942939	0	MLH1	99,103	MSH2	93,97	MLH1	MSH2	4292	4436	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2 , MLH1 , MSH6 , and PMS2 responsible for hereditary nonpolyposis colorectal_cancer -LRB- HNPCC -RRB- .
16237223	0	MLH1	119,123	MSH2	125,129	MLH1	MSH2	4292	4436	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Assay validation for identification of hereditary_nonpolyposis_colon cancer-causing mutations in mismatch repair genes MLH1 , MSH2 , and MSH6 .
16540742	0	MLH1	73,77	MSH2	79,83	MLH1	MSH2	4292	4436	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Optimization of antibodies for detection of the mismatch repair proteins MLH1 , MSH2 , MSH6 , and PMS2 using a biotin-free visualization system .
17724798	0	MLH1	29,33	MSH2	53,57	MLH1	MSH2	4292	4436	Gene	Gene	homologue|nsubj|START_ENTITY homologue|dobj|expression expression|nummod|END_ENTITY	Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal_cancer .
18787700	0	MLH1	6,10	MSH2	120,124	MLH1	MSH2	4292	4436	Gene	Gene	protein|compound|START_ENTITY participates|nsubj|protein participates|nmod|checkpoint checkpoint|acl|signaling signaling|advcl|repair repair|nsubj|functions functions|nummod|END_ENTITY	Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks , while MSH2 functions in DNA repair .
20708344	0	MLH1	88,92	MSH2	82,86	MLH1	MSH2	4292	4436	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
21242524	0	MLH1	31,35	MSH2	25,29	MLH1	MSH2	17350(Tax:10090)	17685(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Mismatch repair proteins MSH2 , MLH1 , and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining .
22669205	0	MLH1	22,26	MSH2	28,32	MLH1	MSH2	4292	4436	Gene	Gene	KRAS|compound|START_ENTITY KRAS|dep|END_ENTITY	Missense mutations in MLH1 , MSH2 , KRAS , and APC genes in colorectal_cancer patients in Malaysia .
22892529	0	MLH1	48,52	MSH2	54,58	MLH1	MSH2	4292	4436	Gene	Gene	START_ENTITY|dep|MSH6 MSH6|compound|END_ENTITY	Clinical utility gene card for : Lynch_syndrome -LRB- MLH1 , MSH2 , MSH6 , PMS2 , EPCAM -RRB- - update 2012 .
24122742	0	MLH1	104,108	MSH2	67,71	MLH1	MSH2	4292	4436	Gene	Gene	germline|nmod|START_ENTITY germline|nsubj|Excess Excess|nmod|cancers cancers|nmod|END_ENTITY	Excess of extracolonic non-endometrial multiple primary cancers in MSH2 germline mutation carriers over MLH1 .
24924810	0	MLH1	69,73	MSH2	75,79	MLH1	MSH2	4292	4436	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Assessing how reduced expression levels of the mismatch repair genes MLH1 , MSH2 , and MSH6 affect repair efficiency .
24995467	0	MLH1	43,47	MSH2	49,53	MLH1	MSH2	4292	4436	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of DNA mismatch repair proteins MLH1 , MSH2 , and MSH6 in recurrent glioblastoma .
8993979	0	MLH1	13,17	MSH2	44,48	MLH1	MSH2	4292	4436	Gene	Gene	Mutations|nmod|START_ENTITY frequent|nsubj|Mutations frequent|nmod|END_ENTITY	Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal_cancers with microsatellite_instability .
12610360	0	MLH1	68,72	MSH6	80,84	MLH1	MSH6	4292	2956	Gene	Gene	START_ENTITY|appos|MSH2 MSH2|nummod|END_ENTITY	The immunohistochemical detection of mismatch repair gene proteins -LRB- MLH1 , MSH2 , MSH6 , and PMS2 -RRB- : practical aspects in antigen retrieval and biotin blocking protocols .
15483016	0	MLH1	151,155	MSH6	99,103	MLH1	MSH6	4292	2956	Gene	Gene	mutations|nummod|START_ENTITY families|nmod|mutations germline|advcl|families germline|nsubj|incidence incidence|nmod|age age|nmod|onset onset|nmod|families families|nmod|END_ENTITY	Lower incidence of colorectal_cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations : the German Hereditary_Nonpolyposis_Colorectal_Cancer_Consortium .
15942939	0	MLH1	99,103	MSH6	105,109	MLH1	MSH6	4292	2956	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2 , MLH1 , MSH6 , and PMS2 responsible for hereditary nonpolyposis colorectal_cancer -LRB- HNPCC -RRB- .
16540742	0	MLH1	73,77	MSH6	85,89	MLH1	MSH6	4292	2956	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Optimization of antibodies for detection of the mismatch repair proteins MLH1 , MSH2 , MSH6 , and PMS2 using a biotin-free visualization system .
24919261	0	MLH1	48,52	MSH6	54,58	MLH1	MSH6	4292	2956	Gene	Gene	examination|nmod|START_ENTITY END_ENTITY|nsubj|examination	-LSB- Immunohistochemical examination of MSH2 , PMS2 , MLH1 , MSH6 compared with the analysis of microsatellite instability in colon_adenocarcinoma -RSB- .
20708344	0	MLH1	88,92	XPD	63,66	MLH1	XPD	4292	2068	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	MLH1	88,92	XRCC3	56,61	MLH1	XRCC3	4292	7517	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
12939400	0	MLH1	18,22	p53	43,46	MLH1	p53	4292	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates .
15923109	0	MLK	36,39	mixed-lineage_kinase	14,34	MLK	mixed-lineage kinase	9175	9175	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of mixed-lineage_kinase -LRB- MLK -RRB- activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells .
15258589	0	MLK3	0,4	B-Raf	43,48	MLK3	B-Raf	4296	673	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	MLK3 is required for mitogen activation of B-Raf , ERK and cell proliferation .
15467451	0	MLK3	41,45	mixed_lineage_kinase_3	17,39	MLK3	mixed lineage kinase 3	4296	4296	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for mixed_lineage_kinase_3 -LRB- MLK3 -RRB- in B-Raf activation and cell proliferation .
22700880	0	MLK3	0,4	paxillin	15,23	MLK3	paxillin	26403(Tax:10090)	19303(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	MLK3 regulates paxillin phosphorylation in chemokine-mediated breast_cancer cell migration and invasion to drive metastasis .
24703947	0	MLKL	41,45	RIP3	106,110	MLKL	RIP3	197259	11035	Gene	Gene	causes|nsubj|START_ENTITY causes|nmod|END_ENTITY	Mixed_lineage_kinase_domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3 .
8950979	0	MLL	14,17	AF-6	49,53	MLL	AF-6	4297	4301	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Fusion of the MLL gene with two different genes , AF-6 and AF-5alpha , by a complex translocation involving chromosomes 5 , 6 , 8 and 11 in infant_leukemia .
8703835	0	MLL	42,45	ALL-1	35,40	MLL	ALL-1	4297	100310785	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Exon/intron structure of the human ALL-1 -LRB- MLL -RRB- gene involved in translocations to chromosomal region 11q23 and acute_leukaemias .
11196198	0	MLL	41,44	ALL1	46,50	MLL	ALL1	4297	100310785	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The partial nontandem duplication of the MLL -LRB- ALL1 -RRB- gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell_acute_lymphoblastic_leukemia .
26308138	0	MLL	11,14	CD7	31,34	MLL	CD7	4297	924	Gene	Gene	CD56|compound|START_ENTITY CD56|compound|END_ENTITY	Aggressive MLL gene rearranged CD7 + CD56 + myeloid/natural killer cell precursor acute leukaemia with extramedullary relapse in the uterus and breast .
24736461	0	MLL	0,3	CDK6	32,36	MLL	CDK6	4297	1021	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL .
12620411	0	MLL	22,25	FLT3	14,18	MLL	FLT3	214162(Tax:10090)	14255(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of FLT3 in MLL .
18024407	0	MLL	43,46	FLT3	30,34	MLL	FLT3	4297	2322	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid_acute_lymphoblastic_leukemia .
11110714	0	MLL	72,75	GMPS	85,89	MLL	GMPS	4297	8833	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	t -LRB- 3 ; 11 -RRB- translocation in treatment-related acute_myeloid_leukemia fuses MLL with the GMPS -LRB- GUANOSINE 5 ' MONOPHOSPHATE SYNTHETASE -RRB- gene .
24886118	0	MLL	31,34	KMT2A	24,29	MLL	KMT2A	4297	4297	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	De Novo variants in the KMT2A -LRB- MLL -RRB- gene causing atypical Wiedemann-Steiner_syndrome in two unrelated individuals identified by clinical exome sequencing .
17968322	0	MLL	80,83	LAF4	54,58	MLL	LAF4	4297	3899	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Identification of the novel AML1 fusion partner gene , LAF4 , a fusion partner of MLL , in childhood T-cell_acute_lymphoblastic_leukemia with t -LRB- 2 ; 21 -RRB- -LRB- q11 ; q22 -RRB- by bubble PCR method for cDNA .
19549311	0	MLL	0,3	MLL	80,83	MLL	MLL	4297	4297	Gene	Gene	rearrangements|compound|START_ENTITY rearrangements|dep|END_ENTITY	MLL rearrangements in pediatric acute_lymphoblastic_and_myeloblastic_leukemias : MLL specific and lineage specific signatures .
19549311	0	MLL	80,83	MLL	0,3	MLL	MLL	4297	4297	Gene	Gene	rearrangements|dep|START_ENTITY rearrangements|compound|END_ENTITY	MLL rearrangements in pediatric acute_lymphoblastic_and_myeloblastic_leukemias : MLL specific and lineage specific signatures .
21665178	0	MLL	115,118	MLL	125,128	MLL	MLL	4297	4297	Gene	Gene	START_ENTITY|nmod|translocation translocation|compound|END_ENTITY	Expression of HOXB genes is significantly different in acute_myeloid_leukemia with a partial_tandem_duplication of MLL vs. a MLL translocation : a cross-laboratory study .
21665178	0	MLL	125,128	MLL	115,118	MLL	MLL	4297	4297	Gene	Gene	translocation|compound|START_ENTITY END_ENTITY|nmod|translocation	Expression of HOXB genes is significantly different in acute_myeloid_leukemia with a partial_tandem_duplication of MLL vs. a MLL translocation : a cross-laboratory study .
19710696	0	MLL	24,27	Mixed-lineage-leukemia	0,22	MLL	Mixed-lineage-leukemia	214162(Tax:10090)	214162(Tax:10090)	Gene	Gene	fusion|appos|START_ENTITY fusion|amod|END_ENTITY	Mixed-lineage-leukemia -LRB- MLL -RRB- fusion protein collaborates with Ras to induce acute_leukemia through aberrant Hox expression and Raf activation .
21998658	0	MLL	61,64	Mixed_Lineage_Leukemia	37,59	MLL	Mixed Lineage Leukemia	4297	4297	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	3 ` UTR-mediated gene silencing of the Mixed_Lineage_Leukemia -LRB- MLL -RRB- gene .
15087374	0	MLL	107,110	breakpoint-cluster_region	68,93	MLL	breakpoint-cluster region	4297	613	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster_region of the human MLL gene .
20093773	0	MLL	12,15	c-Myb	0,5	MLL	c-Myb	4297	4602	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis .
21896721	0	MLL	51,54	mixed_lineage_leukemia_1	25,49	MLL	mixed lineage leukemia 1	4297	4297	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Function of leukemogenic mixed_lineage_leukemia_1 -LRB- MLL -RRB- fusion proteins through distinct partner protein complexes .
17066095	0	MLL	35,38	tumor_necrosis_factor-related_apoptosis-inducing_ligand	56,111	MLL	tumor necrosis factor-related apoptosis-inducing ligand	4297	8743	Gene	Gene	rearrangement|compound|START_ENTITY rearrangement|nmod|END_ENTITY	Resistance of infant_leukemia with MLL rearrangement to tumor_necrosis_factor-related_apoptosis-inducing_ligand : a possible mechanism for poor sensitivity to antitumor immunity .
12885467	0	MLL-3	60,65	AF4	66,69	MLL-3	AF4	58508	4299	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Insertion of chromosome 11 in chromosome 4 resulting in a 5 ` MLL-3 ` AF4 fusion gene in a case of adult acute_lymphoblastic_leukemia .
22902925	0	MLL-AF9	115,122	C/EBPa	72,78	MLL-AF9	C/EBPa	4297	1050	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
22902925	0	MLL-AF9	115,122	DACH1	58,63	MLL-AF9	DACH1	4297	1602	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
22902925	0	MLL-AF9	115,122	HOXA9	14,19	MLL-AF9	HOXA9	4297	3205	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of HOXA9 activity by predominant expression of DACH1 against C/EBPa and GATA-1 in myeloid_leukemia with MLL-AF9 .
18082152	0	MLL1	41,45	CpG_binding_protein	6,25	MLL1	CpG binding protein	4297	30827	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human CpG_binding_protein interacts with MLL1 , MLL2 and hSet1 and regulates Hox gene expression .
14970849	0	MLL1	6,10	TRITHORAX	38,47	MLL1	TRITHORAX	4297	41737(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	ALL-1 / MLL1 , a homologue of Drosophila TRITHORAX , modifies chromatin and is directly involved in infant acute_leukaemia .
24813891	0	MLL1	42,46	histone_methyltransferase	4,29	MLL1	histone methyltransferase	4297	3176	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The histone_methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis .
24831003	0	MLL1	43,47	mixed_lineage_leukemia_1	18,42	MLL1	mixed lineage leukemia 1	4297	4297	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Identification of mixed_lineage_leukemia_1 -LRB- MLL1 -RRB- protein as a coactivator of heat_shock_factor_1 -LRB- HSF1 -RRB- protein in response to heat_shock_protein_90 -LRB- HSP90 -RRB- inhibition .
23629655	0	MLL5	26,30	Mixed_lineage_leukemia_5	0,24	MLL5	Mixed lineage leukemia 5	55904	55904	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Mixed_lineage_leukemia_5 -LRB- MLL5 -RRB- protein regulates cell cycle progression and E2F1-responsive gene expression via association with host_cell_factor-1 -LRB- HCF-1 -RRB- .
26164398	0	MLLT1	12,17	KMT2A	0,5	MLLT1	KMT2A	4298	4297	Gene	Gene	rearrangement|compound|START_ENTITY END_ENTITY|dep|rearrangement	KMT2A -LRB- MLL -RRB- - MLLT1 rearrangement in blastic plasmacytoid dendritic_cell_neoplasm .
21496004	0	MLLT11	31,37	MIR29B	0,6	MLLT11	MIR29B	10962	407024	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MIR29B regulates expression of MLLT11 -LRB- AF1Q -RRB- , an MLL fusion partner , and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML .
10673329	0	MLL_septin-like_fusion	76,98	MSF	105,108	MLL septin-like fusion	MSF	10216	10216	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic and expression analyses of alternatively spliced transcripts of the MLL_septin-like_fusion gene -LRB- MSF -RRB- that map to a 17q25 region of loss in breast_and_ovarian_tumors .
17375189	0	MLN51	0,5	RNA-helicase	21,33	MLN51	RNA-helicase	22794	55308	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	MLN51 stimulates the RNA-helicase activity of eIF4AIII .
17375189	0	MLN51	0,5	eIF4AIII	46,54	MLN51	eIF4AIII	22794	9775	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	MLN51 stimulates the RNA-helicase activity of eIF4AIII .
16519896	0	MLP	31,34	muscle_LIM_protein	11,29	MLP	muscle LIM protein	117505(Tax:10116)	117505(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for muscle_LIM_protein -LRB- MLP -RRB- in vascular remodeling .
15958794	0	MLPH	56,60	melanophilin	37,49	MLPH	melanophilin	171531(Tax:10090)	171531(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal assignment of the canine melanophilin gene -LRB- MLPH -RRB- : a candidate gene for coat color dilution in Pinschers .
17519392	0	MLPH	31,35	melanophilin	12,24	MLPH	melanophilin	607077(Tax:9615)	607077(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A noncoding melanophilin gene -LRB- MLPH -RRB- SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs .
12761180	0	MLTK	64,68	mitogen-activated_protein_kinase_kinase_kinase	16,62	MLTK	mitogen-activated protein kinase kinase kinase	51776	65268	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of a mitogen-activated_protein_kinase_kinase_kinase , MLTK by PKN .
25294237	0	MLXIPL	55,61	MLX_interacting_protein-like	25,53	MLXIPL	MLX interacting protein-like	51085	51085	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Is C771G polymorphism of MLX_interacting_protein-like -LRB- MLXIPL -RRB- gene a novel genetic risk factor for non-alcoholic_fatty_liver_disease ?
26177557	0	MLXIPL	55,61	MLX_interacting_protein-like	25,53	MLXIPL	MLX interacting protein-like	51085	51085	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Is C771G polymorphism of MLX_interacting_protein-like -LRB- MLXIPL -RRB- gene a novel genetic risk factor for non-alcoholic_fatty_liver_disease ?
25294237	0	MLX_interacting_protein-like	25,53	MLXIPL	55,61	MLX interacting protein-like	MLXIPL	51085	51085	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Is C771G polymorphism of MLX_interacting_protein-like -LRB- MLXIPL -RRB- gene a novel genetic risk factor for non-alcoholic_fatty_liver_disease ?
26177557	0	MLX_interacting_protein-like	25,53	MLXIPL	55,61	MLX interacting protein-like	MLXIPL	51085	51085	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Is C771G polymorphism of MLX_interacting_protein-like -LRB- MLXIPL -RRB- gene a novel genetic risk factor for non-alcoholic_fatty_liver_disease ?
11908870	0	MMAC1	53,58	PTEN	60,64	MMAC1	PTEN	5728	5728	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Primary malignant_lymphoma of the brain : analysis of MMAC1 -LRB- PTEN -RRB- tumor suppressor gene .
9690672	0	MMAC1	6,11	PTEN	0,4	MMAC1	PTEN	5728	5728	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	PTEN -LRB- MMAC1 -RRB- mutations are frequent in primary_glioblastomas -LRB- de novo -RRB- but not in secondary_glioblastomas .
11978483	0	MMH	30,33	OGG1	25,29	MMH	OGG1	4968	4968	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of mammalian OGG1 -LRB- MMH -RRB- in excision of the 8-hydroxyguanine residue in DNA .
26992058	0	MMP-1	21,26	Aryl_Hydrocarbon_Receptor	62,87	MMP-1	Aryl Hydrocarbon Receptor	300339(Tax:10116)	25690(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Kynurenine Modulates MMP-1 and Type-I Collagen Expression via Aryl_Hydrocarbon_Receptor Activation in Dermal Fibroblasts .
14592848	0	MMP-1	30,35	C-reactive_protein	0,18	MMP-1	C-reactive protein	4312	1401	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	C-reactive_protein stimulates MMP-1 expression in U937 histiocytes through Fc -LSB- gamma -RSB- RII and extracellular signal-regulated kinase pathway : : an implication of CRP involvement in plaque destabilization .
21344389	0	MMP-1	50,55	CCAAT-enhancer-binding_protein_beta	0,35	MMP-1	CCAAT-enhancer-binding protein beta	4312	1051	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|amod|END_ENTITY	CCAAT-enhancer-binding_protein_beta activation of MMP-1 gene expression in SW1353 cells : independent roles of extracellular signal-regulated and p90/ribosomal _ S6_kinases .
26687824	0	MMP-1	158,163	CITED2	133,139	MMP-1	CITED2	4312	10370	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Strain-induced mechanotransduction through primary cilia , extracellular ATP , purinergic calcium signaling , and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes .
15728253	0	MMP-1	20,25	Cdc42	0,5	MMP-1	Cdc42	4312	998	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway .
18851945	0	MMP-1	31,36	Ets-1	0,5	MMP-1	Ets-1	4312	2113	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Ets-1 upregulates HER2-induced MMP-1 expression in breast_cancer cells .
25339983	0	MMP-1	47,52	Fra-1	0,5	MMP-1	Fra-1	4312	8061	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Fra-1 regulation of Matrix_Metallopeptidase-1 -LRB- MMP-1 -RRB- in metastatic variants of MDA-MB-231 breast_cancer cells .
23840483	0	MMP-1	52,57	Heme_oxygenase-1	0,16	MMP-1	Heme oxygenase-1	4312	3162	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Heme_oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes .
17921324	0	MMP-1	17,22	IL-17	0,5	MMP-1	IL-17	4312	3605	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK - and ERK1/2-dependent C/EBP-beta , NF-kappaB , and AP-1 activation .
21345293	0	MMP-1	16,21	Leptin	0,6	MMP-1	Leptin	4312	3952	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Leptin enhances MMP-1 , MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients .
12824028	0	MMP-1	51,56	MMP-13	22,28	MMP-1	MMP-13	4312	4322	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	Phosphinic_acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3 .
11478691	0	MMP-1	14,19	MMP-8	21,26	MMP-1	MMP-8	4312	4317	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Evaluation of MMP-1 , MMP-8 , MMP-9 serum levels in patients with adrenal_tumors prior to and after surgery .
26422857	0	MMP-1	18,23	MMP-8	25,30	MMP-1	MMP-8	4312	4317	Gene	Gene	PDGF-AB|compound|START_ENTITY PDGF-AB|dep|END_ENTITY	Evaluation of GCF MMP-1 , MMP-8 , TGF-b1 , PDGF-AB , and VEGF levels in periodontally healthy smokers .
10820278	0	MMP-1	87,92	MMP-9	111,116	MMP-1	MMP-9	4312	4318	Gene	Gene	matrix_metalloproteinase-1|dep|START_ENTITY matrix_metalloproteinase-1|ccomp|decreasing decreasing|dobj|production production|compound|END_ENTITY	Th2 cell membrane factors in association with IL-4 enhance matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- while decreasing MMP-9 production by granulocyte-macrophage_colony-stimulating_factor-differentiated human monocytes .
11119537	0	MMP-1	123,128	MMP-9	97,102	MMP-1	MMP-9	4312	4318	Gene	Gene	matrix_metalloproteinase_gelatinase_B|appos|START_ENTITY matrix_metalloproteinase_gelatinase_B|appos|END_ENTITY	Borrelia spirochetes upregulate release and activation of matrix_metalloproteinase_gelatinase_B -LRB- MMP-9 -RRB- and collagenase 1 -LRB- MMP-1 -RRB- in human cells .
11478691	0	MMP-1	14,19	MMP-9	28,33	MMP-1	MMP-9	4312	4318	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Evaluation of MMP-1 , MMP-8 , MMP-9 serum levels in patients with adrenal_tumors prior to and after surgery .
16786739	0	MMP-1	54,59	MMP-9	68,73	MMP-1	MMP-9	4312	4318	Gene	Gene	START_ENTITY|dep|MMP-13 MMP-13|dep|END_ENTITY	-LSB- Correlations between serum matrix metalloproteinase -LRB- MMP-1 , MMP-3 , MMP-9 , MMP-13 -RRB- concentrations and markers of disease activity in early rheumatoid_arthritis -RSB- .
16970595	0	MMP-1	54,59	MMP-9	85,90	MMP-1	MMP-9	4312	4318	Gene	Gene	combining|dobj|START_ENTITY combining|advcl|acid acid|amod|END_ENTITY	Longitudinal evaluation of a fibrosis index combining MMP-1 and PIIINP compared with MMP-9 , TIMP-1 and hyaluronic acid in patients with chronic hepatitis_C treated by interferon-alpha and ribavirin .
25339983	0	MMP-1	47,52	Matrix_Metallopeptidase-1	20,45	MMP-1	Matrix Metallopeptidase-1	4312	4312	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Fra-1 regulation of Matrix_Metallopeptidase-1 -LRB- MMP-1 -RRB- in metastatic variants of MDA-MB-231 breast_cancer cells .
14550952	0	MMP-1	51,56	Matrix_metalloproteinase-1	23,49	MMP-1	Matrix metalloproteinase-1	4312	4312	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	A relationship between Matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- promoter polymorphism and cervical cancer progression .
18507028	0	MMP-1	90,95	PAR-1	51,56	MMP-1	PAR-1	4312	2149	Gene	Gene	protease-activated_receptor-1|appos|START_ENTITY protease-activated_receptor-1|appos|END_ENTITY	Prognostic value of protease-activated_receptor-1 -LRB- PAR-1 -RRB- and matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- in gastric_cancer .
21966428	0	MMP-1	142,147	PAR-1	103,108	MMP-1	PAR-1	4312	2149	Gene	Gene	protease-activated_receptor-1|appos|START_ENTITY protease-activated_receptor-1|appos|END_ENTITY	Galectin-3 facilitates cell motility in gastric_cancer by up-regulating protease-activated_receptor-1 -LRB- PAR-1 -RRB- and matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- .
22086466	0	MMP-1	0,5	PAR-1	6,11	MMP-1	PAR-1	4312	2149	Gene	Gene	START_ENTITY|appos|signal signal|nsubj|END_ENTITY	MMP-1 / PAR-1 signal transduction axis and its prognostic impact in esophageal_squamous_cell_carcinoma .
26170698	0	MMP-1	14,19	PAR-1	20,25	MMP-1	PAR-1	4312	2149	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of MMP-1 / PAR-1 and patterns of invasion in oral_squamous_cell_carcinoma as potential prognostic markers .
26783471	0	MMP-1	4,9	PAR-1	10,15	MMP-1	PAR-1	17386(Tax:10090)	14062(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|Cells Cells|nsubj|Proliferation Proliferation|compound|END_ENTITY	The MMP-1 / PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells .
23687338	0	MMP-1	6,11	PAR1	34,38	MMP-1	PAR1	4312	145624	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination .
9499937	0	MMP-1	33,38	PF4	0,3	MMP-1	PF4	4312	5196	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	PF4 inhibits thrombin-stimulated MMP-1 and MMP-3 metalloproteinase expression in human vascular endothelial cells .
16549373	0	MMP-1	44,49	Runx2	146,151	MMP-1	Runx2	4312	860	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells : potential role of Runx2 in mediating p38 effects .
16455304	0	MMP-1	69,74	SCC-S2	8,14	MMP-1	SCC-S2	4312	25816	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2 , MMP-1 , and MMP-9 expression .
25926075	0	MMP-1	68,73	STAT3	90,95	MMP-1	STAT3	4312	6774	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Activation Activation|compound|END_ENTITY	Lung_Adenocarcinomas and Lung_Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation .
26422857	0	MMP-1	18,23	TGF-b1	32,38	MMP-1	TGF-b1	4312	7040	Gene	Gene	PDGF-AB|compound|START_ENTITY PDGF-AB|dep|END_ENTITY	Evaluation of GCF MMP-1 , MMP-8 , TGF-b1 , PDGF-AB , and VEGF levels in periodontally healthy smokers .
12120711	0	MMP-1	26,31	TIMP-1	33,39	MMP-1	TIMP-1	300339(Tax:10116)	116510(Tax:10116)	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Sequential expressions of MMP-1 , TIMP-1 , IL-6 , and COX-2 genes in induced periapical_lesions in rats .
17217211	0	MMP-1	41,46	TIMP-1	87,93	MMP-1	TIMP-1	4312	7076	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-1 , MMP-2 and MMP-9 -RRB- and their inhibitors -LRB- TIMP-1 and TIMP-2 -RRB- in oral_submucous_fibrosis .
26058005	0	MMP-1	78,83	TIMP-1	116,122	MMP-1	TIMP-1	4312	7076	Gene	Gene	metalloproteinases|dep|START_ENTITY metalloproteinases|appos|END_ENTITY	In vitro effect of caffeic_acid_phenethyl_ester on matrix metalloproteinases -LRB- MMP-1 and MMP-9 -RRB- and their inhibitor -LRB- TIMP-1 -RRB- in lipopolysaccharide-activated human monocytes .
10792621	0	MMP-1	28,33	beta2-microglobulin	0,19	MMP-1	beta2-microglobulin	4312	567	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	beta2-microglobulin induces MMP-1 but not TIMP-1 expression in human synovial fibroblasts .
8776762	0	MMP-1	61,66	fibroblast_collagenase	37,59	MMP-1	fibroblast collagenase	4312	4312	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and purification of human fibroblast_collagenase -LRB- MMP-1 -RRB- expressed in the methylotrophic yeast Pichia_pastoris .
19577645	0	MMP-1	101,106	matrix_metalloproteinase	75,99	MMP-1	matrix metalloproteinase	4312	4312	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Site controlled transgenic_mice validating increased expression from human matrix_metalloproteinase -LRB- MMP-1 -RRB- promoter due to a naturally occurring SNP .
11039223	0	MMP-1	32,37	matrix_metalloproteinase-1	4,30	MMP-1	matrix metalloproteinase-1	4312	4312	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression in the human endometrium is inversely regulated by interleukin-1_alpha and sex steroids .
11741975	0	MMP-1	68,73	matrix_metalloproteinase-1	40,66	MMP-1	matrix metalloproteinase-1	4312	4312	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	A single nucleotide polymorphism in the matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- promoter influences amnion cell MMP-1 expression and risk for preterm premature_rupture of the fetal membranes .
18571622	0	MMP-1	44,49	matrix_metalloproteinase-1	16,42	MMP-1	matrix metalloproteinase-1	4312	4312	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression in oral_carcinomas of betel quid -LRB- BQ -RRB- users : roles of BQ ingredients in the acceleration of tumour cell motility through MMP-1 .
18705799	0	MMP-1	82,87	matrix_metalloproteinase-1	54,80	MMP-1	matrix metalloproteinase-1	4312	4312	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	The effect of a single nucleotide polymorphism in the matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- promoter on force-induced MMP-1 expression in human periodontal ligament cells .
21359852	0	MMP-1	60,65	matrix_metalloproteinase-1	32,58	MMP-1	matrix metalloproteinase-1	4312	4312	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epidermal growth factor induces matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression and invasion in glioma cell lines via the MAPK pathway .
21730072	0	MMP-1	80,85	matrix_metalloproteinase-1	52,78	MMP-1	matrix metalloproteinase-1	17386(Tax:10090)	17386(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TLR4 protein contributes to cigarette smoke-induced matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression in chronic_obstructive_pulmonary_disease .
24587395	0	MMP-1	66,71	matrix_metalloproteinase-1	38,64	MMP-1	matrix metalloproteinase-1	4312	4312	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Extra-cellular matrix proteins induce matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- activity and increase airway smooth muscle contraction in asthma .
16549373	0	MMP-1	44,49	p38	75,78	MMP-1	p38	4312	1432	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells : potential role of Runx2 in mediating p38 effects .
11908571	0	MMP-1	91,96	tumor_necrosis_factor-alpha	32,59	MMP-1	tumor necrosis factor-alpha	4312	7124	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of interleukin_1beta , tumor_necrosis_factor-alpha , and interstitial collagenase -LRB- MMP-1 -RRB- is eicosanoid dependent in human osteoarthritis synovial membrane explants : interactions with antiinflammatory cytokines .
18164189	0	MMP-1	30,35	type_I_procollagen	53,71	MMP-1	type I procollagen	4312	1278	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Berberine prevents UV-induced MMP-1 and reduction of type_I_procollagen expression in human dermal fibroblasts .
22142512	0	MMP-10	13,19	CRP	0,3	MMP-10	CRP	4319	1401	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	CRP promotes MMP-10 expression via c-Raf/MEK/ERK and JAK1/ERK pathways in cardiomyocytes .
20032397	0	MMP-10	15,21	IL-6	0,4	MMP-10	IL-6	4319	3569	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung_adenocarcinoma cell line .
19317417	0	MMP-10	35,41	MMP-9	9,14	MMP-10	MMP-9	4319	4318	Gene	Gene	up-regulation|compound|START_ENTITY END_ENTITY|dep|up-regulation	Vascular MMP-9 / TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke : a combined laser microdissection and protein array study .
21998657	0	MMP-10	0,6	stromelysin-2	7,20	MMP-10	stromelysin-2	4319	4319	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	MMP-10 / stromelysin-2 promotes invasion of head_and_neck_cancer .
9662124	0	MMP-10	41,47	stromelysin-2	26,39	MMP-10	stromelysin-2	4319	4319	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Stromelysin-1 _ -LRB- MMP-3 -RRB- and stromelysin-2 -LRB- MMP-10 -RRB- expression in developing human bone : potential roles in skeletal development .
15272933	0	MMP-11	15,21	stromelysin-3	23,36	MMP-11	stromelysin-3	17385(Tax:10090)	17385(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Stimulation of MMP-11 -LRB- stromelysin-3 -RRB- expression in mouse fibroblasts by cytokines , collagen and co-culture with human breast_cancer cell lines .
22799384	0	MMP-12	45,51	Fucosyltransferase_IV	0,21	MMP-12	Fucosyltransferase IV	4321	2526	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Fucosyltransferase_IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2 , p38 and NF-kB pathways in A431 cells .
22771631	0	MMP-12	86,92	MMP-13	93,99	MMP-12	MMP-13	4321	4322	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	N-O-isopropyl_sulfonamido-based hydroxamates : kinetic characterisation of a series of MMP-12 / MMP-13 dual target inhibitors .
26676790	0	MMP-12	28,34	PAR2	50,54	MMP-12	PAR2	4321	2150	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the Long-Term Airway Inflammation and Airway Hyperresponsiveness Induced by Respiratory_Syncytial_Virus Infection .
10993890	0	MMP-12	67,73	macrophage_elastase	46,65	MMP-12	macrophage elastase	17381(Tax:10090)	17381(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Proteinase-activated receptor-1 regulation of macrophage_elastase -LRB- MMP-12 -RRB- secretion by serine proteinases .
15605420	0	MMP-12	34,40	macrophage_elastase	13,32	MMP-12	macrophage elastase	17381(Tax:10090)	17381(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of macrophage_elastase -LRB- MMP-12 -RRB- gene expression by statins .
16636074	0	MMP-13	43,49	Cbfa-1	0,6	MMP-13	Cbfa-1	17386(Tax:10090)	12393(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	Cbfa-1 mediates nitric_oxide regulation of MMP-13 in osteoblasts .
16144844	0	MMP-13	45,51	GADD45beta	17,27	MMP-13	GADD45beta	17386(Tax:10090)	17873(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation .
26378022	0	MMP-13	31,37	Golgi_protein_73	0,16	MMP-13	Golgi protein 73	4322	51280	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Golgi_protein_73 activation of MMP-13 promotes hepatocellular_carcinoma cell invasion .
21278254	0	MMP-13	15,21	IL-6	0,4	MMP-13	IL-6	4322	3569	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells .
12824028	0	MMP-13	22,28	MMP-1	51,56	MMP-13	MMP-1	4322	4312	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	Phosphinic_acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3 .
22771631	0	MMP-13	93,99	MMP-12	86,92	MMP-13	MMP-12	4322	4321	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	N-O-isopropyl_sulfonamido-based hydroxamates : kinetic characterisation of a series of MMP-12 / MMP-13 dual target inhibitors .
19929954	0	MMP-13	121,127	MMP-9	128,133	MMP-13	MMP-9	4322	4318	Gene	Gene	cascade|compound|START_ENTITY cascade|compound|END_ENTITY	Proteolytic roles of matrix metalloproteinase -LRB- MMP -RRB- -13 during progression of chronic_periodontitis : initial evidence for MMP-13 / MMP-9 activation cascade .
20407279	0	MMP-13	46,52	MMP-9	23,28	MMP-13	MMP-9	17386(Tax:10090)	17395(Tax:10090)	Gene	Gene	gelatinase|appos|START_ENTITY gelatinase|appos|END_ENTITY	Absence of gelatinase -LRB- MMP-9 -RRB- or collagenase -LRB- MMP-13 -RRB- attenuates adriamycin-induced albuminuria and glomerulosclerosis .
26298724	0	MMP-13	69,75	MicroRNA-148a	0,13	MMP-13	MicroRNA-148a	4322	406940	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-148a inhibits migration of breast_cancer cells by targeting MMP-13 .
15564063	0	MMP-13	14,20	RUNX2	35,40	MMP-13	RUNX2	4322	860	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage .
19422937	0	MMP-13	16,22	Runx2	27,32	MMP-13	Runx2	4322	860	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of MMP-13 via Runx2 in the stromal cell of Giant_Cell_Tumor_of_bone .
26721462	0	MMP-13	87,93	S100A4	46,52	MMP-13	S100A4	171052(Tax:10116)	24615(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Involvement of fibroblast-specific protein 1 -LRB- S100A4 -RRB- and matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- in CCl4-induced reversible liver_fibrosis .
26305372	0	MMP-13	32,38	SERPINE2	0,8	MMP-13	SERPINE2	4322	5270	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	SERPINE2 Inhibits IL-1a-Induced MMP-13 Expression in Human Chondrocytes : Involvement of ERK/NF-kB/AP -1 Pathways .
26305372	0	MMP-13	32,38	SERPINE2	0,8	MMP-13	SERPINE2	4322	5270	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	SERPINE2 Inhibits IL-1a-Induced MMP-13 Expression in Human Chondrocytes : Involvement of ERK/NF-kB/AP -1 Pathways .
25147440	0	MMP-13	36,42	amphiregulin	15,27	MMP-13	amphiregulin	4322	374	Gene	Gene	production|compound|START_ENTITY induced|dobj|production END_ENTITY|acl|induced	The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast .
20067416	0	MMP-13	36,42	c-Maf	62,67	MMP-13	c-Maf	4322	4094	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte .
23218521	0	MMP-13	43,49	matrix_metalloproteinase-13	14,41	MMP-13	matrix metalloproteinase-13	395683(Tax:9031)	395683(Tax:9031)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- in the testes of growing and adult chicken .
15026307	0	MMP-13	52,58	matrix_metalloproteinase_13	23,50	MMP-13	matrix metalloproteinase 13	171052(Tax:10116)	171052(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Nmp4/CIZ regulation of matrix_metalloproteinase_13 -LRB- MMP-13 -RRB- response to parathyroid_hormone in osteoblasts .
15074358	0	MMP-13	65,71	matrix_metalloproteinase_13	36,63	MMP-13	matrix metalloproteinase 13	17386(Tax:10090)	17386(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of matrix_metalloproteinase_13 -LRB- MMP-13 -RRB- in mouse mandibular condylar cartilage .
11145962	1	MMP-13	102,108	transforming_growth_factor-beta	126,157	MMP-13	transforming growth factor-beta	4322	7040	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	a role for matrix vesicle-associated MMP-13 in activation of transforming_growth_factor-beta .
21419107	0	MMP-14	56,62	HOXD10	87,93	MMP-14	HOXD10	4323	3236	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10 .
10515879	0	MMP-14	131,137	MMP-2	97,102	MMP-14	MMP-2	4323	4313	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Fibronectin upregulates gelatinase B -LRB- MMP-9 -RRB- and induces coordinated expression of gelatinase A -LRB- MMP-2 -RRB- and its activator MT1-MMP -LRB- MMP-14 -RRB- by human T lymphocyte cell lines .
9325265	0	MMP-14	33,39	matrix_metalloproteinase-14	4,31	MMP-14	matrix metalloproteinase-14	17387(Tax:10090)	17387(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The matrix_metalloproteinase-14 -LRB- MMP-14 -RRB- gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis .
23228395	0	MMP-15	119,125	matrix_metalloproteinase-15	90,117	MMP-15	matrix metalloproteinase-15	4324	4324	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Multiple steps of HLA-G in ovarian_carcinoma metastasis : alter NK cytotoxicity and induce matrix_metalloproteinase-15 -LRB- MMP-15 -RRB- expression .
26700939	0	MMP-19	29,35	Estrogen_Receptor_b	0,19	MMP-19	Estrogen Receptor b	58223(Tax:10090)	13983(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Estrogen_Receptor_b controls MMP-19 expression in mouse ovaries during ovulation .
22200661	0	MMP-2	15,20	ADAM17	0,6	MMP-2	ADAM17	4313	6868	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate_cancer cell invasion .
11739124	0	MMP-2	37,42	AP-2	81,85	MMP-2	AP-2	17390(Tax:10090)	21418(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Estradiol upregulates mesangial cell MMP-2 activity via the transcription factor AP-2 .
15670768	0	MMP-2	23,28	Angiotensin_II	0,14	MMP-2	Angiotensin II	4313	183	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces MMP-2 in a p47phox-dependent manner .
24219285	0	MMP-2	58,63	Angiotensin_II	0,14	MMP-2	Angiotensin II	4313	183	Gene	Gene	activity|compound|START_ENTITY enhancement|nmod|activity downregulates|dobj|enhancement downregulates|nsubj|END_ENTITY	Angiotensin_II downregulates ACE2-mediated enhancement of MMP-2 activity in human cardiofibroblasts .
26071572	0	MMP-2	38,43	Angiotensin_II	0,14	MMP-2	Angiotensin II	4313	183	Gene	Gene	expresison|compound|START_ENTITY increase|nmod|expresison induces|dobj|increase induces|nsubj|END_ENTITY	Angiotensin_II induces an increase in MMP-2 expresison in idiopathic_ascending_aortic_aneurysm via AT1 receptor and JNK pathway .
26631755	0	MMP-2	19,24	B7-H3	25,30	MMP-2	B7-H3	4313	80381	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|END_ENTITY	The interaction of MMP-2 / B7-H3 in human osteoporosis .
21316839	0	MMP-2	51,56	BAG3	0,4	MMP-2	BAG3	4313	9531	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BAG3 -LRB- BCL2-associated_athanogene_3 -RRB- interacts with MMP-2 to positively regulate invasion by ovarian_carcinoma cells .
26622824	0	MMP-2	62,67	BRD4	0,4	MMP-2	BRD4	4313	23476	Gene	Gene	activation|amod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway .
23889688	0	MMP-2	79,84	Bcl-2	103,108	MMP-2	Bcl-2	81686(Tax:10116)	24224(Tax:10116)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Delayed cardioprotective effects of WY-14643 are associated with inhibition of MMP-2 and modulation of Bcl-2 family proteins through PPAR-a activation in rat hearts subjected to global ischaemia-reperfusion .
19258038	0	MMP-2	29,34	Bcl2	0,4	MMP-2	Bcl2	4313	596	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Bcl2 enhances c-Myc-mediated MMP-2 expression of vascular smooth muscle cells .
16996112	0	MMP-2	0,5	CA_125	33,39	MMP-2	CA 125	4313	94025	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	MMP-2 expression associates with CA_125 and clinical course in endometrial_carcinoma .
15904490	0	MMP-2	42,47	CD147	15,20	MMP-2	CD147	4313	682	Gene	Gene	overexpression|nmod|START_ENTITY Involvement|nmod|overexpression Involvement|nmod|END_ENTITY	Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1 .
24996644	0	MMP-2	35,40	CD147	20,25	MMP-2	CD147	4313	682	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Full-length soluble CD147 promotes MMP-2 expression and is a potential serological marker in detection of hepatocellular_carcinoma .
16000878	0	MMP-2	24,29	CD9	12,15	MMP-2	CD9	4313	928	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK , JNK and c-Jun pathways in human melanoma cells .
25806956	0	MMP-2	75,80	COX-2	89,94	MMP-2	COX-2	4313	4513	Gene	Gene	RANK/RANKL|compound|START_ENTITY RANK/RANKL|appos|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
18062285	0	MMP-2	19,24	E-cadherin	26,36	MMP-2	E-cadherin	4313	999	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The expression of MMP-2 , E-cadherin in supraglottic_carcinoma and their relationship with cervical lymph node metastasis -RSB- .
26304749	0	MMP-2	84,89	EGFR-ERK	49,57	MMP-2	EGFR-ERK	4313	1956;5594	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal_cell_carcinoma .
26304749	0	MMP-2	84,89	EGFR-ERK	49,57	MMP-2	EGFR-ERK	4313	1956;5594	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal_cell_carcinoma .
16046057	0	MMP-2	148,153	EMMPRIN	133,140	MMP-2	EMMPRIN	4313	682	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of reversion-inducing_cysteine-rich_protein_with_kazal_motifs -LRB- RECK -RRB- and extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- , with MMP-2 , MMP-9 , and survival in colorectal_cancer .
18035727	0	MMP-2	41,46	EMMPRIN	101,108	MMP-2	EMMPRIN	4313	682	Gene	Gene	matrix_metalloproteinase|appos|START_ENTITY matrix_metalloproteinase|appos|END_ENTITY	-LSB- Expression of matrix_metalloproteinase -LRB- MMP-2 -RRB- and extracellular matrix_metalloproteinases inducer -LRB- EMMPRIN -RRB- in benign and advanced breast_cancer tissue samples -RSB- .
23471663	0	MMP-2	38,43	ER-b	57,61	MMP-2	ER-b	17390(Tax:10090)	13983(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Raloxifene upregulated mesangial cell MMP-2 activity via ER-b through transcriptional regulation .
16815629	0	MMP-2	45,50	ERK1/2	129,135	MMP-2	ERK1/2	17390(Tax:10090)	26417;26413	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nmod|line line|nmod|pathway pathway|compound|END_ENTITY	siRNA targeted against HAb18G/CD147 inhibits MMP-2 secretion , actin and FAK expression in hepatocellular_carcinoma cell line via ERK1/2 pathway .
22211962	0	MMP-2	83,88	ERK1/2	154,160	MMP-2	ERK1/2	4313	5595;5594	Gene	Gene	expression|amod|START_ENTITY suppresses|dobj|expression suppresses|nmod|suppression suppression|nmod|MAPK MAPK|compound|END_ENTITY	The butanol fraction of guava -LRB- Psidium cattleianum Sabine -RRB- leaf extract suppresses MMP-2 and MMP-9 expression and activity through the suppression of the ERK1/2 MAPK signaling pathway .
22282250	0	MMP-2	15,20	ERK1/2	59,65	MMP-2	ERK1/2	4313	5595;5594	Gene	Gene	START_ENTITY|nmod|resistance resistance|amod|dependent dependent|nmod|END_ENTITY	Involvement of MMP-2 in adriamycin resistance dependent on ERK1/2 signal pathway in human osteosarcoma MG-63 cells .
23790167	0	MMP-2	121,126	ERK1/2	97,103	MMP-2	ERK1/2	4313	5595;5594	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	p21-activated_kinase_4 regulation of endometrial_cancer cell migration and invasion involves the ERK1/2 pathway mediated MMP-2 secretion .
25563790	0	MMP-2	141,146	ERK1/2	100,106	MMP-2	ERK1/2	4313	5595;5594	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Nobiletin inhibits invasion and migration of human nasopharyngeal_carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2 .
16417466	0	MMP-2	29,34	Endothelin-1	0,12	MMP-2	Endothelin-1	4313	1906	Gene	Gene	induction|amod|START_ENTITY promotes|dobj|induction promotes|nsubj|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma .
22550139	0	MMP-2	0,5	Erk1/2	16,22	MMP-2	Erk1/2	17390(Tax:10090)	26417;26413	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	MMP-2 regulates Erk1/2 phosphorylation and aortic_dilatation in Marfan_syndrome .
23377549	0	MMP-2	60,65	FGF-1	66,71	MMP-2	FGF-1	4313	2246	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2 / FGF-1 / FGFR-1-dependent pathway in endothelial cells in vitro .
26559469	0	MMP-2	98,103	GM-CSF	84,90	MMP-2	GM-CSF	101098838	493805(Tax:9685)	Gene	Gene	TGF-b|appos|START_ENTITY TGF-b|compound|END_ENTITY	Gene expression profiles of some cytokines , growth factors , receptors , and enzymes -LRB- GM-CSF , IFNy , MMP-2 , IGF-II , EGF , TGF-b , IGF-IIR -RRB- during pregnancy in the cat uterus .
26513500	0	MMP-2	50,55	IGF-1	0,5	MMP-2	IGF-1	4313	3479	Gene	Gene	Level|nmod|START_ENTITY Regulates|dobj|Level Regulates|nsubj|END_ENTITY	IGF-1 Regulates the Extracellular Level of Active MMP-2 and Promotes M ller Glial Cell Motility .
23843954	0	MMP-2	46,51	IL-1b	20,25	MMP-2	IL-1b	81686(Tax:10116)	24494(Tax:10116)	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Carvedilol decrease IL-1b and TNF-a , inhibits MMP-2 , MMP-9 , COX-2 , and RANKL expression , and up-regulates OPG in a rat model of periodontitis .
25531650	0	MMP-2	63,68	IL-1b	31,36	MMP-2	IL-1b	81686(Tax:10116)	24494(Tax:10116)	Gene	Gene	RANK/RANKL|nmod:npmod|START_ENTITY RANK/RANKL|dep|END_ENTITY	Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
22349830	0	MMP-2	8,13	IL-6	35,39	MMP-2	IL-6	4313	3569	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of MMP-2 in the regulation of IL-6 / Stat3 survival signaling via interaction with a5b1 integrin in glioma .
25358651	0	MMP-2	12,17	IL-6	0,4	MMP-2	IL-6	4313	3569	Gene	Gene	MMP-9|amod|START_ENTITY END_ENTITY|amod|MMP-9	IL-6 , IL-8 , MMP-2 , MMP-9 are overexpressed in Fanconi_anemia cells through a NF-kB/TNF-a dependent mechanism .
16474180	0	MMP-2	55,60	Integrin-linked_kinase	0,22	MMP-2	Integrin-linked kinase	4313	3611	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Integrin-linked_kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells .
22082235	0	MMP-2	90,95	JNK	111,114	MMP-2	JNK	4313	5599	Gene	Gene	expression|compound|START_ENTITY expression|nmod|signaling signaling|compound|END_ENTITY	EGCG inhibits the invasion of highly invasive CL1-5 lung_cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest .
10515879	0	MMP-2	97,102	MMP-14	131,137	MMP-2	MMP-14	4313	4323	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Fibronectin upregulates gelatinase B -LRB- MMP-9 -RRB- and induces coordinated expression of gelatinase A -LRB- MMP-2 -RRB- and its activator MT1-MMP -LRB- MMP-14 -RRB- by human T lymphocyte cell lines .
10389763	0	MMP-2	140,145	MMP-2	42,47	MMP-2	MMP-2	4313	4313	Gene	Gene	expression|compound|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane_type-1_MMP .
10389763	0	MMP-2	42,47	MMP-2	140,145	MMP-2	MMP-2	4313	4313	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|compound|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane_type-1_MMP .
12039803	0	MMP-2	140,145	MMP-2	155,160	MMP-2	MMP-2	4313	4313	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Factor_Xa releases matrix metalloproteinase-2 -LRB- MMP-2 -RRB- from human vascular smooth muscle cells and stimulates the conversion of pro-MMP-2 to MMP-2 : role of MMP-2 in factor_Xa-induced DNA synthesis and matrix invasion .
12039803	0	MMP-2	155,160	MMP-2	140,145	MMP-2	MMP-2	4313	4313	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Factor_Xa releases matrix metalloproteinase-2 -LRB- MMP-2 -RRB- from human vascular smooth muscle cells and stimulates the conversion of pro-MMP-2 to MMP-2 : role of MMP-2 in factor_Xa-induced DNA synthesis and matrix invasion .
12439941	0	MMP-2	14,19	MMP-2	52,57	MMP-2	MMP-2	4313	4313	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of MMP-2 , TIMP-2 protein and the ratio of MMP-2 / TIMP-2 in gallbladder_carcinoma and their significance .
12439941	0	MMP-2	52,57	MMP-2	14,19	MMP-2	MMP-2	4313	4313	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of MMP-2 , TIMP-2 protein and the ratio of MMP-2 / TIMP-2 in gallbladder_carcinoma and their significance .
15144129	0	MMP-2	0,5	MMP-9	7,12	MMP-2	MMP-9	4313	4318	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	MMP-2 , MMP-9 , TIMP-1 and TIMP-2 levels in patients with rheumatoid_arthritis and psoriatic_arthritis .
15556929	0	MMP-2	36,41	MMP-9	28,33	MMP-2	MMP-9	4313	4318	Gene	Gene	Matrix_metalloproteinase-9|appos|START_ENTITY Matrix_metalloproteinase-9|appos|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- , MMP-2 , and serum elastase activity are associated with systolic_hypertension and arterial stiffness .
18540849	0	MMP-2	113,118	MMP-9	89,94	MMP-2	MMP-9	4313	4318	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Culture of human A375 melanoma cells in the presence of fibronectin causes expression of MMP-9 and activation of MMP-2 in culture supernatants .
20137537	0	MMP-2	83,88	MMP-9	95,100	MMP-2	MMP-9	81686(Tax:10116)	81687(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY expression|nmod|mRNA Effects|appos|expression Effects|appos|mRNA mRNA|compound|END_ENTITY	-LSB- Effects of losartan and simvastatin on collagen content , myocardial expression of MMP-2 mRNA , MMP-9 mRNA and TIMP-1 mRNA , TIMP-2 mRNA in pressure overload rat hearts -RSB- .
25806956	0	MMP-2	75,80	MMP-9	82,87	MMP-2	MMP-9	4313	4318	Gene	Gene	RANK/RANKL|compound|START_ENTITY RANK/RANKL|appos|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
9561025	0	MMP-2	119,124	MMP-9	125,130	MMP-2	MMP-9	17390(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
10206300	0	MMP-2	14,19	MT1-MMP	89,96	MMP-2	MT1-MMP	4313	4323	Gene	Gene	Gelatinase-A|appos|START_ENTITY Gelatinase-A|appos|END_ENTITY	Gelatinase-A -LRB- MMP-2 -RRB- , gelatinase-B -LRB- MMP-9 -RRB- and membrane_type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- are involved in different aspects of the pathophysiology of malignant_gliomas .
10685633	0	MMP-2	42,47	MT1-MMP	98,105	MMP-2	MT1-MMP	4313	4323	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Expression of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and of membrane-type-1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in transitional_cell_carcinoma of the upper urinary tract .
10840163	0	MMP-2	89,94	MT1-MMP	121,128	MMP-2	MT1-MMP	4313	4323	Gene	Gene	matrix_metalloproteinase-2|dep|START_ENTITY upregulates|amod|matrix_metalloproteinase-2 upregulates|appos|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor upregulates matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and membrane_type-1_MMP -LRB- MT1-MMP -RRB- in human head_and_neck_cancer cells .
10861447	0	MMP-2	152,157	MT1-MMP	111,118	MMP-2	MT1-MMP	4313	4323	Gene	Gene	membrane-type_matrix_metalloproteinase-1|appos|START_ENTITY membrane-type_matrix_metalloproteinase-1|appos|END_ENTITY	Expression of integrin_alpha -LRB- v -RRB- beta -LRB- 3 -RRB- correlates with activation of membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- and matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- in human melanoma cells in vitro and in vivo .
10878545	0	MMP-2	57,62	MT1-MMP	135,142	MMP-2	MT1-MMP	4313	4323	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|correlate correlate|appos|END_ENTITY	Expression and activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and its co-localization with membrane-type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- correlate with melanoma progression .
10895974	0	MMP-2	86,91	MT1-MMP	158,165	MMP-2	MT1-MMP	4313	4323	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY activation|nmod|matrix_metalloproteinase-2 correlated|nsubjpass|activation correlated|nmod|expression expression|amod|membrane-type-1_matrix_metalloproteinase membrane-type-1_matrix_metalloproteinase|dep|END_ENTITY	Matrix metalloproteinases in human gliomas : activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- may be correlated with membrane-type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- expression .
11161720	0	MMP-2	90,95	MT1-MMP	0,7	MMP-2	MT1-MMP	4313	4323	Gene	Gene	maturation|nmod|START_ENTITY promotes|dobj|maturation promotes|nsubj|activation activation|compound|END_ENTITY	MT1-MMP initiates activation of pro-MMP-2 and integrin_alphavbeta3 promotes maturation of MMP-2 in breast_carcinoma cells .
11420151	0	MMP-2	14,19	MT1-MMP	67,74	MMP-2	MT1-MMP	4313	4323	Gene	Gene	activation|appos|START_ENTITY activation|dep|dependence dependence|nmod|expression expression|compound|END_ENTITY	Gelatinase A -LRB- MMP-2 -RRB- activation by skin fibroblasts : dependence on MT1-MMP expression and fibrillar collagen form .
11857380	0	MMP-2	108,113	MT1-MMP	56,63	MMP-2	MT1-MMP	4313	4323	Gene	Gene	activation|compound|START_ENTITY associated|nmod|activation associated|nsubjpass|Expression Expression|nmod|membrane_type_1_matrix_metalloproteinase membrane_type_1_matrix_metalloproteinase|appos|END_ENTITY	Expression of membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization .
12056775	0	MMP-2	40,45	MT1-MMP	82,89	MMP-2	MT1-MMP	4313	4323	Gene	Gene	Expression|nmod|START_ENTITY membrane|nsubj|Expression membrane|dobj|type type|appos|END_ENTITY	Expression of matrix_metalloprotease-2 -LRB- MMP-2 -RRB- and the activator membrane type 1 -LRB- MT1-MMP -RRB- in canine mammary carcinomas .
12480918	0	MMP-2	106,111	MT1-MMP	48,55	MMP-2	MT1-MMP	4313	4323	Gene	Gene	accumulation|nmod|START_ENTITY leading|nmod|accumulation inhibits|advcl|leading inhibits|dobj|activity activity|compound|END_ENTITY	-LRB- - -RRB- Epigallocatechin-3-gallate directly inhibits MT1-MMP activity , leading to accumulation of nonactivated MMP-2 at the cell surface .
15297252	0	MMP-2	14,19	MT1-MMP	120,127	MMP-2	MT1-MMP	4313	4323	Gene	Gene	Activation|nmod|START_ENTITY mediated|nsubjpass|Activation mediated|nmod|expression expression|nmod|END_ENTITY	Activation of MMP-2 in response to vascular_injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP .
17341206	0	MMP-2	57,62	MT1-MMP	25,32	MMP-2	MT1-MMP	4313	4323	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|amod|dependent dependent|amod|END_ENTITY	Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa -LRB- human cervical_cancer -RRB- cells .
18627313	0	MMP-2	99,104	MT1-MMP	27,34	MMP-2	MT1-MMP	4313	4323	Gene	Gene	activation|nmod|START_ENTITY step|nmod|activation step|nsubj|Dimerization Dimerization|nmod|END_ENTITY	Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells .
22006368	0	MMP-2	69,74	MT1-MMP	82,89	MMP-2	MT1-MMP	4313	4323	Gene	Gene	involves|xcomp|START_ENTITY osteoblasts|acl:relcl|involves END_ENTITY|nsubj|osteoblasts	Mechanical forces-induced human osteoblasts differentiation involves MMP-2 / MMP-13 / MT1-MMP proteolytic cascade .
22140598	0	MMP-2	128,133	MT1-MMP	42,49	MMP-2	MT1-MMP	4313	4323	Gene	Gene	expression|nmod|START_ENTITY correlates|nmod|expression correlates|nsubj|Membrane_type-1_matrix_metalloproteinase Membrane_type-1_matrix_metalloproteinase|appos|END_ENTITY	Membrane_type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- correlates with the expression and activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- in inflammatory breast_cancer .
23166329	0	MMP-2	110,115	MT1-MMP	163,170	MMP-2	MT1-MMP	4313	4323	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Neurokinin-1_receptor directly mediates glioma cell migration by up-regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- .
23796708	0	MMP-2	18,23	MT1-MMP	0,7	MMP-2	MT1-MMP	4313	4323	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells .
25317077	0	MMP-2	171,176	MT1-MMP	120,127	MMP-2	MT1-MMP	4313	4323	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY activation|nmod|matrix_metalloproteinase_2 activation|appos|END_ENTITY	High threshold of b1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase -LRB- MT1-MMP -RRB- activation of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- .
9062387	0	MMP-2	24,29	MT1-MMP	0,7	MMP-2	MT1-MMP	4313	4323	Gene	Gene	potential|compound|START_ENTITY correlates|nmod|potential correlates|nsubj|END_ENTITY	MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast_carcinoma cells .
9294857	0	MMP-2	27,32	MT1-MMP	61,68	MMP-2	MT1-MMP	4313	4323	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Co-ordinated expression of MMP-2 and its putative activator , MT1-MMP , in human placentation .
9748137	0	MMP-2	61,66	MT1-MMP	52,59	MMP-2	MT1-MMP	4313	4323	Gene	Gene	messenger|compound|START_ENTITY membrane_type_1_matrix_metalloproteinase|dep|messenger membrane_type_1_matrix_metalloproteinase|appos|END_ENTITY	Augmented membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- : MMP-2 messenger RNA ratio in gastric_carcinomas with poor prognosis .
9794486	0	MMP-2	141,146	MT1-MMP	86,93	MMP-2	MT1-MMP	81686(Tax:10116)	81707(Tax:10116)	Gene	Gene	membrane_type_matrix_metalloproteinase_1|appos|START_ENTITY membrane_type_matrix_metalloproteinase_1|appos|END_ENTITY	Coordinated and cell-specific regulation of membrane_type_matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- and its substrate matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- by physiological signals during follicular development and ovulation .
10880236	0	MMP-2	49,54	Macrophage_migration_inhibitory_factor	0,38	MMP-2	Macrophage migration inhibitory factor	4313	4282	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor increases MMP-2 activity in DU-145 prostate cells .
26025700	0	MMP-2	28,33	Matrix_metalloproteinase-2	0,26	MMP-2	Matrix metalloproteinase-2	4313	4313	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- gene polymorphism and cardiovascular comorbidity in type 2 diabetes patients .
10896208	0	MMP-2	28,33	Matrix_metalloproteinase_2	0,26	MMP-2	Matrix metalloproteinase 2	4313	4313	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- immunoreactive protein is associated with poor grade and survival in brain_neoplasms .
9658163	0	MMP-2	68,73	Mpv17	52,57	MMP-2	Mpv17	17390(Tax:10090)	17527(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts , the kidney , and the inner ear of mice .
16417466	0	MMP-2	29,34	NF-kappaB	90,99	MMP-2	NF-kappaB	4313	4790	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma .
19768635	0	MMP-2	31,36	NF-kappaB	92,101	MMP-2	NF-kappaB	4313	4790	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|advcl|reducing reducing|dobj|activities activities|nmod|END_ENTITY	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung_cancer cells .
20654108	0	MMP-2	22,27	NF-kappaB	88,97	MMP-2	NF-kappaB	4313	4790	Gene	Gene	expressions|amod|START_ENTITY upregulates|dobj|expressions upregulates|advcl|activating activating|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Visfatin upregulates MMP-2 and MMP-9 expressions in human monocytes through activating NF-kappaB -RSB- .
26622883	0	MMP-2	14,19	NGAL	59,63	MMP-2	NGAL	4313	3934	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|END_ENTITY	Evaluation of MMP-2 , MMP-9 , TIMP-1 , TIMP-2 , NGAL and MMP-9 / NGAL complex in urine and sera from patients with bladder_cancer .
15554384	0	MMP-2	31,36	Nerve_growth_factor	0,19	MMP-2	Nerve growth factor	4313	4803	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Nerve_growth_factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic_cancer cells .
21104439	0	MMP-2	72,77	Osteopontin	0,11	MMP-2	Osteopontin	4313	6696	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Osteopontin promotes hepatocellular_carcinoma invasion by up-regulating MMP-2 and uPA expression .
21909361	0	MMP-2	52,57	Osteopontin	0,11	MMP-2	Osteopontin	4313	6696	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Osteopontin enhances the expression and activity of MMP-2 via the SDF-1 / CXCR4 axis in hepatocellular_carcinoma cell lines .
24986570	0	MMP-2	18,23	SKP2	102,106	MMP-2	SKP2	4313	6502	Gene	Gene	Imbalance|nmod|START_ENTITY promote|nsubj|Imbalance promote|dep|signaling signaling|nsubj|invasion invasion|nmod|renal_cell_carcinoma renal_cell_carcinoma|nmod|END_ENTITY	Imbalance between MMP-2 , 9 and TIMP-1 promote the invasion and metastasis of renal_cell_carcinoma via SKP2 signaling pathways .
16084059	0	MMP-2	53,58	SPARC	110,115	MMP-2	SPARC	4313	6678	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Effect of resveratrol on matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and Secreted_Protein_Acidic_and_Rich_in_Cysteine -LRB- SPARC -RRB- on human cultured glioblastoma cells .
26501276	0	MMP-2	50,55	STAT3	9,14	MMP-2	STAT3	4313	6774	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|compound|END_ENTITY	Elevated STAT3 Signaling-Mediated Upregulation of MMP-2 / 9 Confers Enhanced Invasion Ability in Multidrug-Resistant Breast Cancer Cells .
19625121	0	MMP-2	48,53	Skp2	0,4	MMP-2	Skp2	4313	6502	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|overexpression overexpression|amod|END_ENTITY	Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung_cancer cells .
26874697	0	MMP-2	33,38	Skp2	0,4	MMP-2	Skp2	4313	6502	Gene	Gene	Expression|nmod|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	Skp2 Regulates the Expression of MMP-2 and MMP-9 , and Enhances the Invasion Potential of Oral_Squamous_Cell_Carcinoma .
21219858	0	MMP-2	74,79	TGF-b1	0,6	MMP-2	TGF-b1	4313	7040	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	TGF-b1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-kB / IL-6 / MMP-2 .
19219652	0	MMP-2	27,32	TGF-beta2	14,23	MMP-2	TGF-beta2	4313	7042	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	The effect of TGF-beta2 on MMP-2 production and activity in highly metastatic human bladder_carcinoma cell line 5637 .
10769686	0	MMP-2	67,72	TIMP-1	120,126	MMP-2	TIMP-1	4313	7076	Gene	Gene	matrix-metalloproteinase-2|appos|START_ENTITY matrix-metalloproteinase-2|appos|END_ENTITY	Nafoxidine modulates the expression of matrix-metalloproteinase-2 -LRB- MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in endothelial cells .
10810401	0	MMP-2	75,80	TIMP-1	141,147	MMP-2	TIMP-1	4313	7076	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10995877	0	MMP-2	41,46	TIMP-1	86,92	MMP-2	TIMP-1	4313	7076	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
12460604	0	MMP-2	14,19	TIMP-1	77,83	MMP-2	TIMP-1	4313	7076	Gene	Gene	Expression|nmod|START_ENTITY counterregulators|nsubj|Expression counterregulators|xcomp|END_ENTITY	Expression of MMP-2 , MMP-9 , and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson 's _ disease .
12890147	0	MMP-2	13,18	TIMP-1	31,37	MMP-2	TIMP-1	4313	7076	Gene	Gene	Gelatinases|dep|START_ENTITY Gelatinases|appos|expression expression|compound|END_ENTITY	Gelatinases -LRB- MMP-2 and MMP-9 -RRB- , TIMP-1 expression and the extent of neovascularization in aggressive_non-Hodgkin 's _ lymphomas .
16101153	0	MMP-2	62,67	TIMP-1	136,142	MMP-2	TIMP-1	4313	7076	Gene	Gene	matrix_metalloproteinases_2_and_7|appos|START_ENTITY matrix_metalloproteinases_2_and_7|appos|END_ENTITY	Quantitative estimation of matrix_metalloproteinases_2_and_7 -LRB- MMP-2 , MMP-7 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases_1_and_2 -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_carcinoma tissue samples .
16188099	0	MMP-2	23,28	TIMP-1	29,35	MMP-2	TIMP-1	4313	7076	Gene	Gene	START_ENTITY|parataxis|induced induced|nsubj|imbalance imbalance|compound|END_ENTITY	-LSB- AP-1 Decoy modulating MMP-2 / TIMP-1 imbalance induced by bleomycin-A5 in pulmonary fibroblasts -RSB- .
17217211	0	MMP-2	48,53	TIMP-1	87,93	MMP-2	TIMP-1	4313	7076	Gene	Gene	MMP-1|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-1 matrix_metalloproteinases|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-1 , MMP-2 and MMP-9 -RRB- and their inhibitors -LRB- TIMP-1 and TIMP-2 -RRB- in oral_submucous_fibrosis .
17879211	0	MMP-2	32,37	TIMP-1	88,94	MMP-2	TIMP-1	4313	7076	Gene	Gene	MMP-9|dep|START_ENTITY inhibitors|amod|MMP-9 inhibitors|amod|END_ENTITY	Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic_nephropathy .
18607832	0	MMP-2	0,5	TIMP-1	7,13	MMP-2	TIMP-1	4313	7076	Gene	Gene	E-cadherin|compound|START_ENTITY E-cadherin|appos|END_ENTITY	MMP-2 , TIMP-1 , E-cadherin , and beta-catenin expression in endometrial_serous_carcinoma compared with low-grade endometrial_endometrioid_carcinoma and proliferative endometrium .
19723139	0	MMP-2	40,45	TIMP-1	81,87	MMP-2	TIMP-1	4313	7076	Gene	Gene	Expression|nmod|START_ENTITY inhibitors|nsubj|Expression inhibitors|xcomp|END_ENTITY	Expression of matrix metalloproteinases MMP-2 , MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic_adenomas .
19953348	0	MMP-2	25,30	TIMP-1	78,84	MMP-2	TIMP-1	4313	7076	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Serum metalloproteinases MMP-2 , MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in patients on hemodialysis .
20712241	0	MMP-2	34,39	TIMP-1	72,78	MMP-2	TIMP-1	4313	7076	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|xcomp|END_ENTITY	-LSB- Plasma matrix metalloproteinases MMP-2 and MMP-9 and tissue inhibitors TIMP-1 and TIMP-2 in children treated for acute_lymphoblastic_leukemia -RSB- .
20853628	0	MMP-2	53,58	TIMP-1	83,89	MMP-2	TIMP-1	4313	7076	Gene	Gene	pro-MMP-1|dep|START_ENTITY metalloproteinases|appos|pro-MMP-1 metalloproteinases|appos|END_ENTITY	-LSB- Evaluation of matrix metalloproteinases -LRB- pro-MMP-1 , MMP-2 ,8 -RRB- and their inhibitor -LRB- TIMP-1 -RRB- contents in patients with occupational_lung_diseases -RSB- .
22712465	0	MMP-2	13,18	TIMP-1	47,53	MMP-2	TIMP-1	4313	7076	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Imbalance of MMP-2 and MMP-9 expression versus TIMP-1 and TIMP-2 reflects increased invasiveness of human testicular germ cell tumours .
23029478	0	MMP-2	44,49	TIMP-1	17,23	MMP-2	TIMP-1	4313	7076	Gene	Gene	activities|compound|START_ENTITY inhibits|dobj|activities inhibits|nsubj|Up-regulation Up-regulation|nmod|END_ENTITY	Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular_carcinoma .
25380883	0	MMP-2	45,50	TIMP-1	87,93	MMP-2	TIMP-1	4313	7076	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|inhibitor inhibitor|nmod|proteinase-1 proteinase-1|appos|END_ENTITY	Increased plasma matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- , tissue inhibitor of proteinase-1 -LRB- TIMP-1 -RRB- , TIMP-2 , and urine MMP-2 concentrations correlate with proteinuria in renal transplant recipients .
25441368	0	MMP-2	41,46	TIMP-1	77,83	MMP-2	TIMP-1	4313	7076	Gene	Gene	Matrix_Metalloproteinases|appos|START_ENTITY Matrix_Metalloproteinases|appos|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
25576870	0	MMP-2	135,140	TIMP-1	99,105	MMP-2	TIMP-1	17390(Tax:10090)	21857(Tax:10090)	Gene	Gene	activities|amod|START_ENTITY induction|nmod|activities induction|compound|END_ENTITY	Platelet-derived_growth_factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities .
26711243	0	MMP-2	20,25	TIMP-1	43,49	MMP-2	TIMP-1	4313	7076	Gene	Gene	Decreases|nmod|START_ENTITY END_ENTITY|nsubj|Decreases	Decreases in plasma MMP-2 / TIMP-2 and MMP-9 / TIMP-1 ratios in uremic patients during hemodialysis .
27034654	0	MMP-2	42,47	TIMP-1	89,95	MMP-2	TIMP-1	4313	7076	Gene	Gene	Matrix_Metalloproteinases|dep|START_ENTITY Matrix_Metalloproteinases|appos|END_ENTITY	Expressions of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-7 , and MMP-9 -RRB- and Their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Inflammatory_Bowel_Diseases .
9561025	0	MMP-2	119,124	TIMP-1	94,100	MMP-2	TIMP-1	17390(Tax:10090)	21857(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression stimulation|nmod|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
10579795	0	MMP-2	72,77	TIMP-2	131,137	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY mRNA|nmod|matrix_metalloproteinase-2 Localization|nmod|mRNA Localization|appos|END_ENTITY	Localization and quantification of mRNA for matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and tissue inhibitor of matrix_metalloproteinase-2 -LRB- TIMP-2 -RRB- in human benign and malignant prostatic tissue .
10810401	0	MMP-2	75,80	TIMP-2	149,155	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10995877	0	MMP-2	41,46	TIMP-2	94,100	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
11373158	0	MMP-2	27,32	TIMP-2	97,103	MMP-2	TIMP-2	282872(Tax:9913)	282093(Tax:9913)	Gene	Gene	metalloproteinases|dep|START_ENTITY metalloproteinases|appos|END_ENTITY	Matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- and tissue_inhibitor-2_of_matrix_metalloproteinases -LRB- TIMP-2 -RRB- in the placenta and interplacental uterine wall in normal cows and in cattle with retention of fetal membranes .
11565199	0	MMP-2	34,39	TIMP-2	60,66	MMP-2	TIMP-2	4313	7077	Gene	Gene	gelatinase|appos|START_ENTITY gelatinase|appos|END_ENTITY	A role for the 72 kDa gelatinase -LRB- MMP-2 -RRB- and its inhibitor -LRB- TIMP-2 -RRB- in human parturition , premature_rupture_of_membranes and intraamniotic_infection .
11802202	0	MMP-2	17,22	TIMP-2	23,29	MMP-2	TIMP-2	4313	7077	Gene	Gene	role|nmod|START_ENTITY role|dep|imbalance imbalance|compound|END_ENTITY	Clinical role of MMP-2 / TIMP-2 imbalance in hepatocellular_carcinoma .
11928819	0	MMP-2	39,44	TIMP-2	84,90	MMP-2	TIMP-2	81686(Tax:10116)	29543(Tax:10116)	Gene	Gene	matrix_metalloproteases|appos|START_ENTITY matrix_metalloproteases|appos|END_ENTITY	Expression of matrix_metalloproteases -LRB- MMP-2 , MT1 _ - MMP -RRB- and their tissue inhibitor -LRB- TIMP-2 -RRB- by rat sertoli cells in culture : implications for spermatogenesis .
12439941	0	MMP-2	14,19	TIMP-2	58,64	MMP-2	TIMP-2	4313	7077	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of MMP-2 , TIMP-2 protein and the ratio of MMP-2 / TIMP-2 in gallbladder_carcinoma and their significance .
12439941	0	MMP-2	52,57	TIMP-2	58,64	MMP-2	TIMP-2	4313	7077	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of MMP-2 , TIMP-2 protein and the ratio of MMP-2 / TIMP-2 in gallbladder_carcinoma and their significance .
12602913	0	MMP-2	0,5	TIMP-2	64,70	MMP-2	TIMP-2	4313	7077	Gene	Gene	protein|compound|START_ENTITY protein|dep|phenotype phenotype|compound|END_ENTITY	MMP-2 protein in invasive breast_cancer and the impact of MMP-2 / TIMP-2 phenotype on overall survival .
12755684	0	MMP-2	59,64	TIMP-2	0,6	MMP-2	TIMP-2	4313	7077	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	TIMP-2 -LRB- tissue_inhibitor_of_metalloproteinase-2 -RRB- regulates MMP-2 -LRB- matrix_metalloproteinase-2 -RRB- activity in the extracellular environment after pro-MMP-2 activation by MT1 _ -LRB- membrane_type_1 -RRB- - MMP .
12801521	0	MMP-2	157,162	TIMP-2	174,180	MMP-2	TIMP-2	4313	7077	Gene	Gene	enhances|dobj|START_ENTITY enhances|nmod|END_ENTITY	Epigallocatechin-3-gallate binding to MMP-2 inhibits gelatinolytic activity without influencing the attachment to extracellular matrix proteins but enhances MMP-2 binding to TIMP-2 .
15374620	0	MMP-2	13,18	TIMP-2	30,36	MMP-2	TIMP-2	282872(Tax:9913)	282093(Tax:9913)	Gene	Gene	Isolation|nmod|START_ENTITY Isolation|dep|complex complex|compound|END_ENTITY	Isolation of MMP-2 from MMP-2 / TIMP-2 complex : characterization of the complex and the free enzyme in pulmonary vascular smooth muscle plasma membrane .
15374620	0	MMP-2	24,29	TIMP-2	30,36	MMP-2	TIMP-2	282872(Tax:9913)	282093(Tax:9913)	Gene	Gene	Isolation|nmod|START_ENTITY Isolation|dep|complex complex|compound|END_ENTITY	Isolation of MMP-2 from MMP-2 / TIMP-2 complex : characterization of the complex and the free enzyme in pulmonary vascular smooth muscle plasma membrane .
15451196	0	MMP-2	67,72	TIMP-2	119,125	MMP-2	TIMP-2	102184364	102178107	Gene	Gene	MT1-MMP|dep|START_ENTITY matrix_metalloproteinases|appos|MT1-MMP matrix_metalloproteinases|appos|END_ENTITY	Expression and localization of matrix_metalloproteinases -LRB- MT1-MMP , MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- during synepitheliochorial placentation of goats -LRB- Capra_hircus -RRB- .
15982804	0	MMP-2	7,12	TIMP-2	82,88	MMP-2	TIMP-2	4313	7077	Gene	Gene	corrected|nsubj|START_ENTITY corrected|ccomp|factors factors|dep|END_ENTITY	Tissue MMP-2 and MMP-9 -LSB- corrected -RSB- are better prognostic factors than serum MMP-2 / TIMP-2 -- complex or TIMP-1 -LSB- corrected -RSB- in stage -LSB- corrected -RSB- I-III lung_carcinoma .
15982804	0	MMP-2	76,81	TIMP-2	82,88	MMP-2	TIMP-2	4313	7077	Gene	Gene	factors|nmod|START_ENTITY factors|dep|END_ENTITY	Tissue MMP-2 and MMP-9 -LSB- corrected -RSB- are better prognostic factors than serum MMP-2 / TIMP-2 -- complex or TIMP-1 -LSB- corrected -RSB- in stage -LSB- corrected -RSB- I-III lung_carcinoma .
16101153	0	MMP-2	62,67	TIMP-2	144,150	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinases_2_and_7|appos|START_ENTITY matrix_metalloproteinases_2_and_7|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Quantitative estimation of matrix_metalloproteinases_2_and_7 -LRB- MMP-2 , MMP-7 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases_1_and_2 -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_carcinoma tissue samples .
16289164	0	MMP-2	19,24	TIMP-2	26,32	MMP-2	TIMP-2	386583(Tax:9031)	374178(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Changes in scleral MMP-2 , TIMP-2 and TGFbeta-2 mRNA expression after imposed myopic and hyperopic defocus in chickens .
17154296	0	MMP-2	80,85	TIMP-2	147,153	MMP-2	TIMP-2	282872(Tax:9913)	282093(Tax:9913)	Gene	Gene	expression|dep|START_ENTITY expression|amod|tissue_inhibitor-2_of_matrix_metalloproteinases tissue_inhibitor-2_of_matrix_metalloproteinases|dep|END_ENTITY	Quantitative analysis of messenger RNA expression of matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- , tissue_inhibitor-2_of_matrix_metalloproteinases -LRB- TIMP-2 -RRB- , and steroidogenic enzymes in bovine placentomes during gestation and postpartum .
17355922	0	MMP-2	1,6	TIMP-2	7,13	MMP-2	TIMP-2	4313	7077	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	-LSB- MMP-2 / TIMP-2 expression in the trophoblasts of patients with gestational_trophoblastic_disease -RSB- .
17374529	0	MMP-2	117,122	TIMP-2	47,53	MMP-2	TIMP-2	4313	7077	Gene	Gene	inhibitor|appos|START_ENTITY Serum|nmod|inhibitor Serum|xcomp|tissue_inhibitor_of_metalloproteinase-2 tissue_inhibitor_of_metalloproteinase-2|dep|END_ENTITY	Serum tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- and matrix_metalloproteinase-2 in complex with the inhibitor -LRB- MMP-2 : TIMP-2 -RRB- as prognostic markers in bladder_cancer .
17466450	0	MMP-2	83,88	TIMP-2	121,127	MMP-2	TIMP-2	4313	7077	Gene	Gene	metalloproteinases|dep|START_ENTITY metalloproteinases|appos|END_ENTITY	Noninvasive diagnosis of bladder_cancer by detection of matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- and their inhibitor -LRB- TIMP-2 -RRB- in urine .
17642161	0	MMP-2	20,25	TIMP-2	27,33	MMP-2	TIMP-2	4313	7077	Gene	Gene	nm23|appos|START_ENTITY Expression|nmod|nm23 END_ENTITY|nsubj|Expression	Expression of nm23 , MMP-2 , TIMP-2 in breast_neoplasm in Zhengzhou Center Hospital , China .
17982970	0	MMP-2	13,18	TIMP-2	19,25	MMP-2	TIMP-2	81686(Tax:10116)	29543(Tax:10116)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	The roles of MMP-2 / TIMP-2 in extracellular matrix remodelling in the hearts of STZ-induced diabetic rats .
18651826	0	MMP-2	42,47	TIMP-2	94,100	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY matrix_metalloproteinase_2|appos|END_ENTITY	Expression of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinase_2 -LRB- TIMP-2 -RRB- in medullary_thyroid_carcinoma : prognostic implications .
19391484	0	MMP-2	74,79	TIMP-2	132,138	MMP-2	TIMP-2	4313	7077	Gene	Gene	metalloproteinases|amod|START_ENTITY immunoexpression|nmod|metalloproteinases immunoexpression|appos|END_ENTITY	Aberrant tubulointerstitial immunoexpression of matrix metalloproteinases MMP-2 , MMP-9 and tissue_inhibitor_of_matrix_proteinase-2 -LRB- TIMP-2 -RRB- in acute cellular rejection of human renal allograft .
20137537	0	MMP-2	83,88	TIMP-2	123,129	MMP-2	TIMP-2	81686(Tax:10116)	29543(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY expression|nmod|mRNA Effects|appos|expression Effects|appos|mRNA mRNA|compound|END_ENTITY	-LSB- Effects of losartan and simvastatin on collagen content , myocardial expression of MMP-2 mRNA , MMP-9 mRNA and TIMP-1 mRNA , TIMP-2 mRNA in pressure overload rat hearts -RSB- .
21526499	0	MMP-2	69,74	TIMP-2	102,108	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY matrix_metalloproteinase_2|appos|END_ENTITY	Clinical significance of serum levels of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and its tissue inhibitor -LRB- TIMP-2 -RRB- in gastric_cancer .
21839835	0	MMP-2	155,160	TIMP-2	87,93	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY activation|nmod|matrix_metalloproteinase-2 inhibits|dobj|activation inhibits|nsubj|Peptide Peptide|nmod|domain domain|nmod|tissue_inhibitor_of_matrix_metalloproteinases-2 tissue_inhibitor_of_matrix_metalloproteinases-2|appos|END_ENTITY	Peptide from the C-terminal domain of tissue_inhibitor_of_matrix_metalloproteinases-2 -LRB- TIMP-2 -RRB- inhibits membrane activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- .
22429332	0	MMP-2	19,24	TIMP-2	25,31	MMP-2	TIMP-2	4313	7077	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Irradiation alters MMP-2 / TIMP-2 system and collagen type IV degradation in brain .
22545131	0	MMP-2	128,133	TIMP-2	0,6	MMP-2	TIMP-2	4313	7077	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression potentiates|advcl|suppressing potentiates|nsubj|protein protein|compound|END_ENTITY	TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression .
22621753	0	MMP-2	41,46	TIMP-2	97,103	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinase|appos|START_ENTITY matrix_metalloproteinase|appos|END_ENTITY	Higher risk of matrix_metalloproteinase -LRB- MMP-2 , 7 , 9 -RRB- and tissue_inhibitor_of_metalloproteinase -LRB- TIMP-2 -RRB- genetic variants to gallbladder_cancer .
23398532	0	MMP-2	24,29	TIMP-2	0,6	MMP-2	TIMP-2	17390(Tax:10090)	21858(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY decreases|dobj|activity decreases|nsubj|mutant mutant|compound|END_ENTITY	TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV_dysfunction and heart_failure .
24384769	0	MMP-2	28,33	TIMP-2	65,71	MMP-2	TIMP-2	4313	7077	Gene	Gene	Matrix_metalloproteinase_2|appos|START_ENTITY inhibitor|nsubj|Matrix_metalloproteinase_2 inhibitor|dobj|2 2|appos|END_ENTITY	Matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and their tissue inhibitor 2 -LRB- TIMP-2 -RRB- in gastric_cancer patients .
24395652	0	MMP-2	66,71	TIMP-2	119,125	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY matrix_metalloproteinase_2|appos|END_ENTITY	Serum levels and tissue expression of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinases_2 -LRB- TIMP-2 -RRB- in colorectal_cancer patients .
24899319	0	MMP-2	43,48	TIMP-2	97,103	MMP-2	TIMP-2	4313	7077	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of matrix_metalloproteinases-2 -LRB- MMP-2 -RRB- and tissue inhibitors of metalloproteinases-2 -LRB- TIMP-2 -RRB- in oral_submucous_fibrosis and their correlation with disease severity .
25380883	0	MMP-2	45,50	TIMP-2	96,102	MMP-2	TIMP-2	4313	7077	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY END_ENTITY|nsubj|matrix_metalloproteinase-2	Increased plasma matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- , tissue inhibitor of proteinase-1 -LRB- TIMP-1 -RRB- , TIMP-2 , and urine MMP-2 concentrations correlate with proteinuria in renal transplant recipients .
25412957	0	MMP-2	29,34	TIMP-2	35,41	MMP-2	TIMP-2	4313	7077	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Stoichiometric expression of MMP-2 / TIMP-2 in benign and malignant_tumours of the salivary gland .
25441368	0	MMP-2	41,46	TIMP-2	85,91	MMP-2	TIMP-2	4313	7077	Gene	Gene	Matrix_Metalloproteinases|appos|START_ENTITY Matrix_Metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
26395636	0	MMP-2	58,63	TIMP-2	102,108	MMP-2	TIMP-2	386583(Tax:9031)	374178(Tax:9031)	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Expression and localization of matrix_metalloproteinases -LRB- MMP-2 , _ -7 , _ -9 -RRB- and their tissue inhibitors -LRB- TIMP-2 , -3 -RRB- in the chicken oviduct during maturation .
26711243	0	MMP-2	20,25	TIMP-2	26,32	MMP-2	TIMP-2	4313	7077	Gene	Gene	Decreases|nmod|START_ENTITY Decreases|dep|END_ENTITY	Decreases in plasma MMP-2 / TIMP-2 and MMP-9 / TIMP-1 ratios in uremic patients during hemodialysis .
27034654	0	MMP-2	42,47	TIMP-2	97,103	MMP-2	TIMP-2	4313	7077	Gene	Gene	Matrix_Metalloproteinases|dep|START_ENTITY Matrix_Metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Expressions of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-7 , and MMP-9 -RRB- and Their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Inflammatory_Bowel_Diseases .
8861023	0	MMP-2	40,45	TIMP-2	0,6	MMP-2	TIMP-2	4313	7077	Gene	Gene	binding|nmod|START_ENTITY mediates|dobj|binding mediates|nsubj|END_ENTITY	TIMP-2 mediates cell surface binding of MMP-2 .
25356871	0	MMP-2	14,19	TLX	0,3	MMP-2	TLX	4313	4179	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TLX activates MMP-2 , promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival .
21344498	0	MMP-2	48,53	TNF-a	20,25	MMP-2	TNF-a	4313	7124	Gene	Gene	production|compound|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Combined effects of TNF-a , IL-1b , and HIF-1a on MMP-2 production in ACL fibroblasts under mechanical stretch : an in vitro study .
25047892	0	MMP-2	89,94	Thrombin	0,8	MMP-2	Thrombin	81686(Tax:10116)	29251(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY stimulates|parataxis|involvement stimulates|nsubj|END_ENTITY	Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway : involvement of MMP-2 .
10865990	0	MMP-2	42,47	VEGF	89,93	MMP-2	VEGF	81686(Tax:10116)	83785(Tax:10116)	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Expression of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in inflammation-associated corneal_neovascularization .
17908800	0	MMP-2	311,316	VEGF	181,185	MMP-2	VEGF	17390(Tax:10090)	22339(Tax:10090)	Gene	Gene	proteolysis|compound|START_ENTITY tissue_growth_factor|nmod|proteolysis Identification|parataxis|tissue_growth_factor Identification|acl|processed processed|nmod|matrix_metalloproteinase_2 matrix_metalloproteinase_2|dep|disruption disruption|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Identification of candidate angiogenic inhibitors processed by matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in cell-based proteomic screens : disruption of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / heparin_affin_regulatory_peptide -LRB- pleiotrophin -RRB- and VEGF/Connective _ tissue_growth_factor angiogenic inhibitory complexes by MMP-2 proteolysis .
17908800	0	MMP-2	91,96	VEGF	181,185	MMP-2	VEGF	17390(Tax:10090)	22339(Tax:10090)	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY matrix_metalloproteinase_2|dep|disruption disruption|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Identification of candidate angiogenic inhibitors processed by matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in cell-based proteomic screens : disruption of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / heparin_affin_regulatory_peptide -LRB- pleiotrophin -RRB- and VEGF/Connective _ tissue_growth_factor angiogenic inhibitory complexes by MMP-2 proteolysis .
18829111	0	MMP-2	13,18	VEGF	40,44	MMP-2	VEGF	4313	7422	Gene	Gene	Secretion|nmod|START_ENTITY induced|nsubj|Secretion induced|nmod|correlates correlates|compound|END_ENTITY	Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical features in childhood acute_lymphoblastic_leukemia .
20027628	0	MMP-2	0,5	VEGF	13,17	MMP-2	VEGF	4313	7422	Gene	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung_cancer cells .
20665024	0	MMP-2	49,54	VEGF	104,108	MMP-2	VEGF	4313	7422	Gene	Gene	gelatinases|amod|START_ENTITY levels|nmod|gelatinases levels|nmod|END_ENTITY	Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis .
23884892	0	MMP-2	47,52	VEGF	0,4	MMP-2	VEGF	4313	7422	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	VEGF secreted by hypoxic M ller cells induces MMP-2 expression and activity in endothelial cells to promote retinal_neovascularization in proliferative_diabetic_retinopathy .
22659470	0	MMP-2	72,77	VEGF-A	113,119	MMP-2	VEGF-A	4313	7422	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Highly invasive melanoma cells activate the vascular endothelium via an MMP-2 / integrin avb5-induced secretion of VEGF-A .
21453685	0	MMP-2	17,22	WISP-1	0,6	MMP-2	WISP-1	4313	8840	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells .
21641389	0	MMP-2	23,28	angiotensin_II	101,115	MMP-2	angiotensin II	4313	183	Gene	Gene	activity|compound|START_ENTITY mediated|nsubjpass|activity mediated|nmod|type type|amod|END_ENTITY	Angiotensin_II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin_II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal_pigment_epithelium : implications for age-related_macular_degeneration .
25867313	0	MMP-2	42,47	angiotensin_II	11,25	MMP-2	angiotensin II	81686(Tax:10116)	24179(Tax:10116)	Gene	Gene	TIMP-1|compound|START_ENTITY Effects|nmod|TIMP-1 Effects|nmod|intervention intervention|amod|END_ENTITY	Effects of angiotensin_II intervention on MMP-2 , MMP-9 , TIMP-1 , and collagen expression in rats with pulmonary_hypertension .
15781321	0	MMP-2	45,50	bFGF	36,40	MMP-2	bFGF	4313	2247	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of basic fibroblast factor -LRB- bFGF -RRB- on MMP-2 , TIMP-2 , and type-I collagen levels in human lung_carcinoma fibroblasts .
12898250	0	MMP-2	32,37	gelatinase_A	18,30	MMP-2	gelatinase A	337179(Tax:7955)	337179(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of gelatinase_A -LRB- MMP-2 -RRB- is required for normal development of zebrafish embryos .
16815061	0	MMP-2	0,5	growth_hormone	48,62	MMP-2	growth hormone	81686(Tax:10116)	81668(Tax:10116)	Gene	Gene	increased|nsubjpass|START_ENTITY increased|nmod|END_ENTITY	MMP-2 in the left rat ventricle is increased by growth_hormone .
24790864	0	MMP-2	39,44	hepatocyte_growth_factor	11,35	MMP-2	hepatocyte growth factor	100719361	100730730	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of hepatocyte_growth_factor on MMP-2 expression in scleral fibroblasts from a guinea_pig myopia model .
21401309	0	MMP-2	57,62	hypoxia_inducible_factor-1a	12,39	MMP-2	hypoxia inducible factor-1a	4313	3091	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	The role of hypoxia_inducible_factor-1a in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles .
9130458	0	MMP-2	14,19	interferon-gamma	63,79	MMP-2	interferon-gamma	4313	3458	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of MMP-2 -LRB- gelatinase A -RRB- and MMP-9 -LRB- gelatinase B -RRB- by interferon-gamma in a human salivary gland cell line .
23349885	0	MMP-2	34,39	interleukin-8	86,99	MMP-2	interleukin-8	4313	3576	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|advcl|inducing inducing|xcomp|END_ENTITY	Human_papillomavirus up-regulates MMP-2 and MMP-9 expression and activity by inducing interleukin-8 in lung_adenocarcinomas .
9327744	0	MMP-2	65,70	interleukin-8	14,27	MMP-2	interleukin-8	4313	3576	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis .
14960229	0	MMP-2	73,78	macrophage_migration_inhibitory_factor	11,49	MMP-2	macrophage migration inhibitory factor	4313	4282	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- on expression of MMP-2 , MMP-9 , and IL-8 in nasopharyngeal_carcinoma cell strains -RSB- .
12238810	0	MMP-2	55,60	matrix_metalloproteinase-2	27,53	MMP-2	matrix metalloproteinase-2	81686(Tax:10116)	81686(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and activity of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- in the development of rat first molar tooth germ .
14530987	0	MMP-2	107,112	matrix_metalloproteinase-2	79,105	MMP-2	matrix metalloproteinase-2	4313	4313	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Influence of cultured dermal fibroblasts on human melanoma cell proliferation , matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- expression and invasion in vitro .
16309203	0	MMP-2	48,53	matrix_metalloproteinase-2	20,46	MMP-2	matrix metalloproteinase-2	4313	4313	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic value of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- expression in endometrial_endometrioid_adenocarcinoma .
16929121	0	MMP-2	42,47	matrix_metalloproteinase-2	14,40	MMP-2	matrix metalloproteinase-2	4313	4313	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Evaluation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- activity with film in situ zymography for improved cytological diagnosis of breast_tumors .
17435175	0	MMP-2	42,47	matrix_metalloproteinase-2	14,40	MMP-2	matrix metalloproteinase-2	4313	4313	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- activity by phosphorylation .
18974156	0	MMP-2	42,47	matrix_metalloproteinase-2	14,40	MMP-2	matrix metalloproteinase-2	4313	4313	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2 .
25767848	0	MMP-2	66,71	matrix_metalloproteinase-2	38,64	MMP-2	matrix metalloproteinase-2	4313	4313	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Captopril and lisinopril only inhibit matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- activity at millimolar concentrations .
9879815	0	MMP-2	64,69	matrix_metalloproteinase-2	36,62	MMP-2	matrix metalloproteinase-2	4313	4313	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Tumor progression and expression of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- mRNA by human urinary bladder_cancer cells .
10433819	0	MMP-2	121,126	matrix_metalloproteinase_2	11,37	MMP-2	matrix metalloproteinase 2	17390(Tax:10090)	17390(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Diminished matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in ectomesenchyme-derived tissues of the Patch mutant mouse : regulation of MMP-2 by PDGF and effects on mesenchymal cell migration .
15167830	0	MMP-2	21,26	matrix_metalloproteinase_2	28,54	MMP-2	matrix metalloproteinase 2	4313	4313	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Comparative study of MMP-2 -LRB- matrix_metalloproteinase_2 -RRB- immune expression in normal uterine cervix , intraepithelial neoplasias , and squamous cells cervical_carcinoma .
23503864	0	MMP-2	79,84	matrix_metalloproteinase_2	51,77	MMP-2	matrix metalloproteinase 2	4313	4313	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Zimography is an effective method for detection of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- activity in cultured human fibroblasts .
21437907	0	MMP-2	79,84	matrix_metalloproteinsase-2	50,77	MMP-2	matrix metalloproteinsase-2	4313	4313	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Endothelial cell microparticles act as centers of matrix_metalloproteinsase-2 -LRB- MMP-2 -RRB- activation and vascular matrix remodeling .
9648071	0	MMP-2	131,136	membrane-type-1-matrix_metalloproteinase	18,58	MMP-2	membrane-type-1-matrix metalloproteinase	17390(Tax:10090)	17387(Tax:10090)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of murine membrane-type-1-matrix_metalloproteinase -LRB- MT-1-MMP -RRB- and its metanephric developmental regulation with respect to MMP-2 and its inhibitor .
10389763	0	MMP-2	140,145	membrane_type-1_MMP	202,221	MMP-2	membrane type-1 MMP	4313	4323	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane_type-1_MMP .
10389763	0	MMP-2	42,47	membrane_type-1_MMP	202,221	MMP-2	membrane type-1 MMP	4313	4323	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane_type-1_MMP .
25866219	0	MMP-2	84,89	miR-29b	0,7	MMP-2	miR-29b	4313	407024	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-29b inhibits the progression of esophageal_squamous_cell_carcinoma by targeting MMP-2 .
14975209	0	MMP-2	79,84	osteopontin	16,27	MMP-2	osteopontin	4313	6696	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of human osteopontin on proliferation , transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells .
20207476	0	MMP-2	56,61	osteopontin	30,41	MMP-2	osteopontin	4313	6696	Gene	Gene	expressions|amod|START_ENTITY downregulates|dobj|expressions downregulates|nsubj|END_ENTITY	A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate_cancer PC-3 cells .
21174062	0	MMP-2	111,116	osteopontin	19,30	MMP-2	osteopontin	17390(Tax:10090)	20750(Tax:10090)	Gene	Gene	mechanism|nmod|START_ENTITY cells|nmod|mechanism metastasis|nmod|cells inhibits|dobj|metastasis inhibits|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of osteopontin inhibits metastasis of hepatocellular_carcinoma cells via a mechanism involving MMP-2 and uPA .
22917927	0	MMP-2	8,13	osteopontin	48,59	MMP-2	osteopontin	17390(Tax:10090)	20750(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY upregulates|nsubj|Loss upregulates|dobj|expression expression|compound|END_ENTITY	Loss of MMP-2 in murine osteoblasts upregulates osteopontin and bone sialoprotein expression in a circuit regulating bone homeostasis .
9639398	0	MMP-2	14,19	osteopontin	70,81	MMP-2	osteopontin	4313	6696	Gene	Gene	START_ENTITY|nmod|cells cells|acl|induced induced|nmod|END_ENTITY	Activation of MMP-2 by human GCT23 giant_cell_tumour cells induced by osteopontin , bone sialoprotein and GRGDSP peptides is RGD and cell shape change dependent .
19590887	0	MMP-2	26,31	p38	47,50	MMP-2	p38	4313	5594	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Mechanical force enhances MMP-2 activation via p38 signaling pathway in human retinal_pigment_epithelial cells .
20683677	0	MMP-2	17,22	p38_MAPK	58,66	MMP-2	p38 MAPK	17390(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Leptin regulates MMP-2 , TIMP-1 and collagen synthesis via p38_MAPK in HL-1 murine cardiomyocytes .
7882615	0	MMP-2	71,76	phospholipase_D	8,23	MMP-2	phospholipase D	4313	2822	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of phospholipase_D in laminin-induced production of gelatinase A -LRB- MMP-2 -RRB- in metastatic cells .
16046057	0	MMP-2	148,153	reversion-inducing_cysteine-rich_protein_with_kazal_motifs	15,73	MMP-2	reversion-inducing cysteine-rich protein with kazal motifs	4313	8434	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of reversion-inducing_cysteine-rich_protein_with_kazal_motifs -LRB- RECK -RRB- and extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- , with MMP-2 , MMP-9 , and survival in colorectal_cancer .
17154296	0	MMP-2	80,85	tissue_inhibitor-2_of_matrix_metalloproteinases	98,145	MMP-2	tissue inhibitor-2 of matrix metalloproteinases	282872(Tax:9913)	282093(Tax:9913)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Quantitative analysis of messenger RNA expression of matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- , tissue_inhibitor-2_of_matrix_metalloproteinases -LRB- TIMP-2 -RRB- , and steroidogenic enzymes in bovine placentomes during gestation and postpartum .
19903858	0	MMP-2	131,136	urokinase_plasminogen_activator_receptor	70,110	MMP-2	urokinase plasminogen activator receptor	4313	5329	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase_plasminogen_activator_receptor signaling-dependent MMP-2 activation .
18340378	0	MMP-2	68,73	vitronectin	86,97	MMP-2	vitronectin	4313	7448	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	The initial steps of ovarian_cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin .
12202640	0	MMP-20	49,55	matrix_metalloproteinase-20	20,47	MMP-20	matrix metalloproteinase-20	64386	64386	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	The localization of matrix_metalloproteinase-20 -LRB- MMP-20 , enamelysin -RRB- in mature human teeth .
15333466	0	MMP-26	29,35	matrilysin-2	15,27	MMP-26	matrilysin-2	56547	56547	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Association of matrilysin-2 -LRB- MMP-26 -RRB- expression with tumor progression and activation of MMP-9 in esophageal_squamous_cell_carcinoma .
12164918	0	MMP-28	10,16	Epilysin	0,8	MMP-28	Epilysin	79148	79148	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Epilysin -LRB- MMP-28 -RRB- expression is associated with cell proliferation during epithelial repair .
20923448	0	MMP-28	54,60	epilysin	44,52	MMP-28	epilysin	79148	79148	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nicotine modulates gelatinase B -LRB- MMP-9 -RRB- and epilysin -LRB- MMP-28 -RRB- expression in reconstituted human oral epithelium .
21321996	0	MMP-3	22,27	Adiponectin	0,11	MMP-3	Adiponectin	4314	9370	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathway .
23277113	0	MMP-3	41,46	Angiotensin_II	0,14	MMP-3	Angiotensin II	4314	183	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Angiotensin_II induces the production of MMP-3 and MMP-13 through the MAPK signaling pathways via the AT -LRB- 1 -RRB- receptor in osteoblasts .
18036345	0	MMP-3	62,67	ERK	83,86	MMP-3	ERK	17392(Tax:10090)	26413(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblasts .
24604010	0	MMP-3	108,113	Eotaxin-1	0,9	MMP-3	Eotaxin-1	4314	6356	Gene	Gene	expression|compound|START_ENTITY pathway|nmod|expression activation|nmod|pathway invasion|nmod|activation promotes|dobj|invasion promotes|nsubj|END_ENTITY	Eotaxin-1 promotes prostate_cancer cell invasion via activation of the CCR3-ERK pathway and upregulation of MMP-3 expression .
23328930	0	MMP-3	42,47	IL-1b	35,40	MMP-3	IL-1b	4314	3553	Gene	Gene	production|compound|START_ENTITY END_ENTITY|appos|production	Resveratrol inhibits TNF-a-induced IL-1b , MMP-3 production in human rheumatoid_arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway .
26937219	0	MMP-3	115,120	MMP-3	82,87	MMP-3	MMP-3	100009111(Tax:9986)	100009111(Tax:9986)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of prunetin on the proteolytic activity , secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo .
26937219	0	MMP-3	82,87	MMP-3	115,120	MMP-3	MMP-3	100009111(Tax:9986)	100009111(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of prunetin on the proteolytic activity , secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo .
23608488	0	MMP-3	60,65	Matrix_metalloproteinase-3	32,58	MMP-3	Matrix metalloproteinase-3	4314	4314	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	IL-4 inhibition of IL-1 induced Matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun_N-terminal_kinase -LRB- JNK -RRB- .
19275880	0	MMP-3	30,35	NF-kappaB	0,9	MMP-3	NF-kappaB	4314	4790	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	NF-kappaB and ZBP-89 regulate MMP-3 expression via a polymorphic site in the promoter .
24984269	0	MMP-3	104,109	NF-kappa_B	75,85	MMP-3	NF-kappa B	4314	4790	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	CCL20/CCR6 promotes the invasion and migration of thyroid_cancer cells via NF-kappa_B signaling-induced MMP-3 production .
16100390	0	MMP-3	39,44	Osteoactivin	0,12	MMP-3	Osteoactivin	17392(Tax:10090)	93695(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Osteoactivin upregulates expression of MMP-3 and MMP-9 in fibroblasts infiltrated into denervated skeletal muscle in mice .
21867693	0	MMP-3	39,44	TNF-a	67,72	MMP-3	TNF-a	4314	7124	Gene	Gene	expression|compound|START_ENTITY expression|dep|induced induced|nmod|END_ENTITY	Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-a and bradykinin in human colonic myofibroblasts .
25956994	0	MMP-3	17,22	TNF-a	0,5	MMP-3	TNF-a	17392(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	TNF-a stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38_MAPK pathway in a murine cementoblast cell line .
19608750	0	MMP-3	64,69	Tissue-type_plasminogen_activator	0,33	MMP-3	Tissue-type plasminogen activator	17392(Tax:10090)	18791(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Tissue-type_plasminogen_activator -LRB- t-PA -RRB- induces stromelysin-1 -LRB- MMP-3 -RRB- in endothelial cells through activation of lipoprotein_receptor-related_protein .
22114952	0	MMP-3	14,19	eotaxin-1	62,71	MMP-3	eotaxin-1	4314	6356	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes .
19608750	0	MMP-3	64,69	lipoprotein_receptor-related_protein	114,150	MMP-3	lipoprotein receptor-related protein	17392(Tax:10090)	16971(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Tissue-type_plasminogen_activator -LRB- t-PA -RRB- induces stromelysin-1 -LRB- MMP-3 -RRB- in endothelial cells through activation of lipoprotein_receptor-related_protein .
24985902	0	MMP-3	50,55	matrix_metalloprotease-3	24,48	MMP-3	matrix metalloprotease-3	171045(Tax:10116)	171045(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Temporary inductions of matrix_metalloprotease-3 -LRB- MMP-3 -RRB- expression and cell apoptosis are associated with tendon_degeneration or rupture after corticosteroid injection .
10672313	0	MMP-3	54,59	matrix_metalloproteinase-3	26,52	MMP-3	matrix metalloproteinase-3	4314	4314	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Selective distribution of matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- in Alzheimer 's _ disease brain .
15993717	0	MMP-3	47,52	matrix_metalloproteinase-3	19,45	MMP-3	matrix metalloproteinase-3	4314	4314	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Association of the matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- promoter polymorphism with celiac_disease in male subjects .
20822909	0	MMP-3	61,66	matrix_metalloproteinase-3	33,59	MMP-3	matrix metalloproteinase-3	4314	4314	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The rs522616 polymorphism in the matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- gene is associated with sporadic brain_arteriovenous_malformation in a Chinese population .
24682924	0	MMP-3	41,46	matrix_metalloproteinase-3	13,39	MMP-3	matrix metalloproteinase-3	4314	4314	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in the microglia by lipopolysaccharide -LRB- LPS -RRB- via upregulation of glycoprotein_nonmetastatic_melanoma_B -LRB- GPNMB -RRB- expression .
12385578	0	MMP-3	61,66	matrix_metalloproteinase_3	33,59	MMP-3	matrix metalloproteinase 3	4314	4314	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The promoter polymorphism of the matrix_metalloproteinase_3 -LRB- MMP-3 -RRB- gene in women with ovarian_cancer .
22215634	0	MMP-7	12,17	BMP-7	33,38	MMP-7	BMP-7	4316	655	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Matrilysin -LRB- MMP-7 -RRB- inhibition of BMP-7 induced renal tubular branching morphogenesis suggests a role in the pathogenesis of human renal_dysplasia .
23790336	0	MMP-7	7,12	COX-2	0,5	MMP-7	COX-2	4316	4513	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	COX-2 , MMP-7 expression in oral_lichen_planus_and_oral_squamous_cell_carcinoma .
24704993	0	MMP-7	0,5	COX-2	24,29	MMP-7	COX-2	4316	5743	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung_adenocarcinoma cells .
19682489	0	MMP-7	91,96	HB-EGF	97,103	MMP-7	HB-EGF	4316	1839	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Cellular senescence of human mammary epithelial cells -LRB- HMEC -RRB- is associated with an altered MMP-7 / HB-EGF signaling and increased formation of elastin-like structures .
20113256	0	MMP-7	28,33	Matrix_metalloproteinase-7	0,26	MMP-7	Matrix metalloproteinase-7	4316	4316	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Matrix_metalloproteinase-7 -LRB- MMP-7 -RRB- polymorphism is a risk factor for endometrial_cancer susceptibility .
8514452	0	MMP-7	14,19	PUMP-1	20,26	MMP-7	PUMP-1	4316	4316	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of MMP-7 -LRB- PUMP-1 -RRB- mRNA in human colorectal_cancers .
17525740	0	MMP-7	58,63	VEGF	4,8	MMP-7	VEGF	4316	7422	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|switch switch|amod|END_ENTITY	The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells .
18974372	0	MMP-7	42,47	VEGF	23,27	MMP-7	VEGF	4316	7422	Gene	Gene	receptor-1|nmod|START_ENTITY END_ENTITY|amod|receptor-1	Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells .
18974372	0	MMP-7	42,47	VEGF	55,59	MMP-7	VEGF	4316	7422	Gene	Gene	receptor-1|nmod|START_ENTITY VEGF|amod|receptor-1 Degradation|nmod|VEGF allows|nsubj|Degradation allows|dobj|access access|amod|END_ENTITY	Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells .
22024063	0	MMP-7	87,92	VEGF	65,69	MMP-7	VEGF	4316	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Immunohistochemical study of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and matrilysin -LRB- MMP-7 -RRB- in T1 adenocarcinoma_of_the_colon_and_rectum to predict lymph node metastases or distant metastases .
23256367	0	MMP-7	55,60	beta-catenin	41,53	MMP-7	beta-catenin	25335(Tax:10116)	84353(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Influence of Bushen Huoxue decoction on beta-catenin , MMP-7 of synoviocytes in rats with knee_osteoarthritis -RSB- .
12851697	0	MMP-7	110,115	epidermal_growth_factor	82,105	MMP-7	epidermal growth factor	4316	1950	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Difference in responsiveness of human esophageal_squamous_cell_carcinoma lines to epidermal_growth_factor for MMP-7 expression .
11927011	0	MMP-7	55,60	matrix_metalloproteinase-7	27,53	MMP-7	matrix metalloproteinase-7	4316	4316	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of matrix_metalloproteinase-7 -LRB- MMP-7 -RRB- expression at the invasive front in gastric_carcinoma .
21224131	0	MMP-7	199,204	matrix_metalloproteinase_7	32,58	MMP-7	matrix metalloproteinase 7	4316	4316	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of recombinant human matrix_metalloproteinase_7 -LRB- Matrilysin -RRB- with potential role in tumor invasion by refolding from Escherichia_coli inclusion bodies and development of sandwich ELISA of MMP-7 .
8531010	0	MMP-7	51,56	matrix_metalloproteinase_matrilysin	14,49	MMP-7	matrix metalloproteinase matrilysin	4316	4316	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of matrix_metalloproteinase_matrilysin -LRB- MMP-7 -RRB- was induced by activated Ki-ras via AP-1 activation in SW1417 colon_cancer cells .
9727011	0	MMP-8	15,20	Collagenase_2	0,13	MMP-8	Collagenase 2	17394(Tax:10090)	17394(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Collagenase_2 -LRB- MMP-8 -RRB- expression in murine tissue-remodeling processes .
11478691	0	MMP-8	21,26	MMP-1	14,19	MMP-8	MMP-1	4317	4312	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Evaluation of MMP-1 , MMP-8 , MMP-9 serum levels in patients with adrenal_tumors prior to and after surgery .
26422857	0	MMP-8	25,30	MMP-1	18,23	MMP-8	MMP-1	4317	4312	Gene	Gene	PDGF-AB|dep|START_ENTITY PDGF-AB|compound|END_ENTITY	Evaluation of GCF MMP-1 , MMP-8 , TGF-b1 , PDGF-AB , and VEGF levels in periodontally healthy smokers .
11478691	0	MMP-8	21,26	MMP-9	28,33	MMP-8	MMP-9	4317	4318	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	Evaluation of MMP-1 , MMP-8 , MMP-9 serum levels in patients with adrenal_tumors prior to and after surgery .
24099107	0	MMP-8	25,30	MMP-9	31,36	MMP-8	MMP-9	4317	4318	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Regulatory expression of MMP-8 / MMP-9 and inhibition of proliferation , migration and invasion in human lung_cancer A549 cells in the presence of HGF variants .
11400153	0	MMP-8	23,28	collagenase-2	8,21	MMP-8	collagenase-2	4317	4317	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	In vivo collagenase-2 -LRB- MMP-8 -RRB- expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis .
12081207	0	MMP-8	44,49	collagenase-2	29,42	MMP-8	collagenase-2	4317	4317	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of collagenase-2 -LRB- MMP-8 -RRB- in head and neck squamous_cell_carcinomas .
12429813	0	MMP-8	50,55	collagenase-2	35,48	MMP-8	collagenase-2	4317	4317	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Airway_obstruction correlates with collagenase-2 -LRB- MMP-8 -RRB- expression and activation in bronchial_asthma .
11005153	0	MMP-8	35,40	matrix_metalloproteinase	9,33	MMP-8	matrix metalloproteinase	4317	4317	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Salivary matrix_metalloproteinase -LRB- MMP-8 -RRB- levels and gelatinase -LRB- MMP-9 -RRB- activities in patients with type_2_diabetes_mellitus .
15672011	0	MMP-8	56,61	matrix_metalloproteinase-8	28,54	MMP-8	matrix metalloproteinase-8	4317	4317	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Midtrimester amniotic fluid matrix_metalloproteinase-8 -LRB- MMP-8 -RRB- levels above the 90th percentile are a marker for subsequent preterm premature rupture_of_membranes .
17254561	0	MMP-8	48,53	matrix_metalloproteinase-8	20,46	MMP-8	matrix metalloproteinase-8	4317	4317	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Correlates of serum matrix_metalloproteinase-8 -LRB- MMP-8 -RRB- concentrations in nondiabetic subjects without cardiovascular_disease .
21320567	0	MMP-9	14,19	A2b_adenosine_receptor	38,60	MMP-9	A2b adenosine receptor	17395(Tax:10090)	11541(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of MMP-9 expression by the A2b_adenosine_receptor and its dependency on TNF-a signaling .
19355890	0	MMP-9	32,37	ACE	52,55	MMP-9	ACE	4318	1636	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Pharmacological implications of MMP-9 inhibition by ACE inhibitors .
20093780	0	MMP-9	0,5	ACE	20,23	MMP-9	ACE	4318	1636	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|inhibitor inhibitor|compound|END_ENTITY	MMP-9 inhibition by ACE inhibitor reduces oxidized LDL-mediated foam-cell formation .
25481090	0	MMP-9	65,70	AKT	95,98	MMP-9	AKT	4318	207	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells .
10935492	0	MMP-9	163,168	AP-1	146,150	MMP-9	AP-1	4318	2353	Gene	Gene	promoter|compound|START_ENTITY site|nmod|promoter site|compound|END_ENTITY	Transcriptional inhibition of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity by a c-fos/estrogen _ receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion .
10935492	0	MMP-9	58,63	AP-1	146,150	MMP-9	AP-1	4318	2353	Gene	Gene	activity|appos|START_ENTITY inhibition|nmod|activity mediated|nsubjpass|inhibition mediated|nmod|site site|compound|END_ENTITY	Transcriptional inhibition of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity by a c-fos/estrogen _ receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion .
17936676	0	MMP-9	15,20	AP-1	54,58	MMP-9	AP-1	4318	3725	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nmod|activation activation|nmod|END_ENTITY	Iron increases MMP-9 expression through activation of AP-1 via ERK/Akt pathway in human head and neck squamous_carcinoma cells .
25200491	0	MMP-9	14,19	AP-1	56,60	MMP-9	AP-1	4318	3726	Gene	Gene	production|compound|START_ENTITY induces|dobj|production END_ENTITY|dep|induces	FSL-1 induces MMP-9 production through TLR-2 and NF-kB / AP-1 signaling pathways in monocytic THP-1 cells .
25875631	0	MMP-9	40,45	AP-1	69,73	MMP-9	AP-1	4318	3725	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
25875631	0	MMP-9	40,45	AP-1	69,73	MMP-9	AP-1	4318	3725	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
24141084	0	MMP-9	97,102	BDNF	59,63	MMP-9	BDNF	4318	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Plasma levels of mature brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in treatment-resistant schizophrenia treated with clozapine .
21136273	0	MMP-9	15,20	BMP-6	0,5	MMP-9	BMP-6	4318	654	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast_cancer cells .
22865631	0	MMP-9	65,70	Bcr/Abl	110,117	MMP-9	Bcr/Abl	4318	25;613	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Gallic_acid downregulates matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and MMP-9 in human leukemia cells with expressed Bcr/Abl .
19450561	0	MMP-9	66,71	Bone_morphogenetic_protein-4	0,28	MMP-9	Bone morphogenetic protein-4	4318	652	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Bone_morphogenetic_protein-4 induced by NDRG2 expression inhibits MMP-9 activity in breast_cancer cells .
19662350	0	MMP-9	37,42	C-reactive_protein	46,64	MMP-9	C-reactive protein	4318	1401	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression and activity of MMP-9 in C-reactive_protein - induced human THP-1 mononuclear cells is related to activation of nuclear_factor_kappa-B .
22138288	0	MMP-9	15,20	CCL2	0,4	MMP-9	CCL2	4318	6347	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK / ERK/NF-kB signaling pathway .
18567920	0	MMP-9	27,32	CD147	86,91	MMP-9	CD147	4318	682	Gene	Gene	expression|compound|START_ENTITY expression|nmod|monocytes/macrophages monocytes/macrophages|nmod|END_ENTITY	Cyclophilin_A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid_arthritis .
20107538	0	MMP-9	33,38	CD147	19,24	MMP-9	CD147	4318	682	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages : Implication for Atherosclerosis .
20473759	0	MMP-9	182,187	CD147	189,194	MMP-9	CD147	4318	682	Gene	Gene	MMP-2|nummod|START_ENTITY MMP-2|nummod|END_ENTITY	Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2 , MMP-9 , CD147 .
21355964	0	MMP-9	30,35	CD147	9,14	MMP-9	CD147	4318	682	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- regulation of MMP-9 in bronchial epithelial cells in COPD .
23536308	0	MMP-9	116,121	CD147	27,32	MMP-9	CD147	4318	682	Gene	Gene	downregulating|dobj|START_ENTITY inhibits|advcl|downregulating inhibits|nsubj|END_ENTITY	RNA interference targeting CD147 inhibits the invasion of human cervical squamous_carcinoma cells by downregulating MMP-9 .
24305990	0	MMP-9	13,18	CD34	31,35	MMP-9	CD34	4318	947	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Differential MMP-9 activity in CD34 -LRB- + -RRB- progenitor cell-derived foam cells from diabetic and normoglycemic patients .
21179773	0	MMP-9	32,37	CGRP	12,16	MMP-9	CGRP	81687(Tax:10116)	24241(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Effects of CGRP on LPS-induced MMP-9 secretion by alveolar macrophages -RSB- .
20472833	0	MMP-9	33,38	EGF	20,23	MMP-9	EGF	4318	1950	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	EGR-1 activation by EGF inhibits MMP-9 expression and lymphoma growth .
21355964	0	MMP-9	30,35	EMMPRIN	0,7	MMP-9	EMMPRIN	4318	682	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	EMMPRIN -LRB- CD147 -RRB- regulation of MMP-9 in bronchial epithelial cells in COPD .
11069776	0	MMP-9	66,71	ERK	10,13	MMP-9	ERK	4318	5594	Gene	Gene	regulation|compound|START_ENTITY sufficient|nmod|regulation sufficient|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells : involvement of Ras-dependent and - independent pathways .
18834856	0	MMP-9	14,19	ERK	35,38	MMP-9	ERK	4318	5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|compound|END_ENTITY	TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells .
19082492	0	MMP-9	50,55	ERK	93,96	MMP-9	ERK	4318	5594	Gene	Gene	downregulation|nmod|START_ENTITY leads|nsubj|downregulation leads|nmod|apoptosis apoptosis|nmod|activation activation|nmod|END_ENTITY	RNAi-mediated downregulation of radiation-induced MMP-9 leads to apoptosis via activation of ERK and Akt in IOMM-Lee cells .
19308943	0	MMP-9	63,68	ERK	83,86	MMP-9	ERK	4318	5594	Gene	Gene	activation|compound|START_ENTITY ameliorates|dobj|activation ameliorates|nmod|pathway pathway|compound|END_ENTITY	Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway .
19837106	0	MMP-9	26,31	ERK	107,110	MMP-9	ERK	17395(Tax:10090)	26413(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nmod|macrophages macrophages|nmod|activation activation|nmod|END_ENTITY	4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38_MAPK .
20107538	0	MMP-9	33,38	ERK	58,61	MMP-9	ERK	4318	5594	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages : Implication for Atherosclerosis .
21205837	0	MMP-9	98,103	ERK	123,126	MMP-9	ERK	4318	5594	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	CXCR4 promotes oral_squamous_cell_carcinoma migration and invasion through inducing expression of MMP-9 and MMP-13 via the ERK signaling pathway .
22326992	0	MMP-9	22,27	ERK	65,68	MMP-9	ERK	17395(Tax:10090)	26413(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|advcl|signaling signaling|nsubj|macrophages macrophages|nmod|END_ENTITY	Homocysteine enhances MMP-9 production in murine macrophages via ERK and Akt signaling pathways .
22814256	0	MMP-9	75,80	ERK	140,143	MMP-9	ERK	17395(Tax:10090)	26413(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY up-regulate|dobj|expression up-regulate|advcl|regulating regulating|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Atorvastatin and simvastatin , but not pravastatin , up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB .
23271730	0	MMP-9	119,124	ERK	105,108	MMP-9	ERK	4318	5594	Gene	Gene	expression|compound|START_ENTITY extracellular_signal-regulated_kinase|dep|expression extracellular_signal-regulated_kinase|appos|END_ENTITY	Interleukin-20 promotes migration of bladder_cancer cells through extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated MMP-9 protein expression leading to nuclear factor -LRB- NF-kB -RRB- activation by inducing the up-regulation of p21 -LRB- WAF1 -RRB- protein expression .
23681803	0	MMP-9	96,101	ERK	154,157	MMP-9	ERK	4318	5594	Gene	Gene	matrix_metalloproteinase_9|appos|START_ENTITY upregulates|dobj|matrix_metalloproteinase_9 upregulates|xcomp|promote promote|advcl|activating activating|dobj|pathways pathways|compound|END_ENTITY	Ataxia-telangiectasia group D complementing gene -LRB- ATDC -RRB- upregulates matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- to promote lung_cancer cell invasion by activating ERK and JNK pathways .
24448387	0	MMP-9	101,106	ERK	174,177	MMP-9	ERK	4318	5594	Gene	Gene	down-regulation|compound|START_ENTITY down-regulation|nmod|cells cells|nmod|suppression suppression|nmod|pathway pathway|compound|END_ENTITY	9-Hydroxypheophorbide_a-mediated photodynamic therapy induces matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and MMP-9 down-regulation in Hep-2 cells via ROS-mediated suppression of the ERK pathway .
25724188	0	MMP-9	42,47	ERK	109,112	MMP-9	ERK	4318	5594	Gene	Gene	Activation|nmod|START_ENTITY promotes|nsubj|Activation promotes|nmod|END_ENTITY	Activation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by neurotensin promotes cell invasion and migration through ERK pathway in gastric_cancer .
25875631	0	MMP-9	40,45	ERK	93,96	MMP-9	ERK	4318	5594	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Pathways Pathways|compound|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
25875631	0	MMP-9	40,45	ERK	93,96	MMP-9	ERK	4318	5594	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Pathways Pathways|compound|END_ENTITY	Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric_Cancer Cells .
23671886	0	MMP-9	71,76	ERK1/2	4,10	MMP-9	ERK1/2	81687(Tax:10116)	50689;116590	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|compound|END_ENTITY	The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina .
12177807	0	MMP-9	48,53	ERK2	34,38	MMP-9	ERK2	4318	5594	Gene	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Integrin alpha -LRB- v -RRB- beta6-associated ERK2 mediates MMP-9 secretion in colon_cancer cells .
26232046	0	MMP-9	22,27	ETB	0,3	MMP-9	ETB	81687(Tax:10116)	50672(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status_epilepticus .
11369454	0	MMP-9	34,39	Edpm5	54,59	MMP-9	Edpm5	81687(Tax:10116)	326390(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Suppression of estrogen-dependent MMP-9 expression by Edpm5 , a genetic locus for pituitary_tumor growth in rat .
20578063	0	MMP-9	63,68	Epidermal_growth_factor	0,23	MMP-9	Epidermal growth factor	282871(Tax:9913)	521832(Tax:9913)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells .
24390612	0	MMP-9	20,25	Filamin_A	0,9	MMP-9	Filamin A	4318	2316	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Filamin_A regulates MMP-9 expression and suppresses prostate_cancer cell migration and invasion .
24575369	0	MMP-9	14,19	Gelatinase_B	0,12	MMP-9	Gelatinase B	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gelatinase_B -LRB- MMP-9 -RRB- gene silencing does not affect murine preadipocyte differentiation .
14631115	0	MMP-9	51,56	IL-1alpha	28,37	MMP-9	IL-1alpha	4318	3552	Gene	Gene	role|nmod|START_ENTITY role|nmod|induction induction|compound|END_ENTITY	Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line .
25531650	0	MMP-9	70,75	IL-1b	31,36	MMP-9	IL-1b	81687(Tax:10116)	24494(Tax:10116)	Gene	Gene	RANK/RANKL|nmod:npmod|START_ENTITY RANK/RANKL|dep|END_ENTITY	Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
25806956	0	MMP-9	82,87	IL-1b	43,48	MMP-9	IL-1b	4318	3553	Gene	Gene	RANK/RANKL|appos|START_ENTITY RANK/RANKL|compound|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
12387824	0	MMP-9	17,22	IL-1beta	0,8	MMP-9	IL-1beta	17395(Tax:10090)	16176(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-1beta induces MMP-9 via reactive oxygen species and NF-kappaB in murine macrophage RAW 264.7 cells .
17158965	0	MMP-9	49,54	IL-1beta	25,33	MMP-9	IL-1beta	4318	3553	Gene	Gene	secretion|compound|START_ENTITY synergizes|nmod|secretion synergizes|nmod|END_ENTITY	IFNgamma synergizes with IL-1beta to up-regulate MMP-9 secretion in a cellular model of central_nervous_system_tuberculosis .
19455716	0	MMP-9	17,22	IL-1beta	0,8	MMP-9	IL-1beta	81687(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-1beta induces MMP-9 expression via a Ca2 + - dependent CaMKII/JNK/c-JUN cascade in rat brain astrocytes .
24829419	0	MMP-9	14,19	IL-23p19	29,37	MMP-9	IL-23p19	17395(Tax:10090)	83430(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Cutting Edge : MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response .
10547161	0	MMP-9	30,35	Interleukin-1beta	0,17	MMP-9	Interleukin-1beta	4318	3553	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant_cell_tumor_of_bone .
17311279	0	MMP-9	26,31	Interleukin-1beta	0,17	MMP-9	Interleukin-1beta	4318	3553	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK , p38 MAPK , JNK , and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells .
20066900	0	MMP-9	18,23	Kiss-1	0,6	MMP-9	Kiss-1	4318	3814	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Kiss-1 suppresses MMP-9 expression by activating p38_MAP_kinase in human stomach_cancer .
25033895	0	MMP-9	17,22	MCP-1	0,5	MMP-9	MCP-1	4318	6347	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MCP-1 stimulates MMP-9 expression via ERK_1 / 2 and p38 MAPK signaling pathways in human aortic smooth muscle cells .
26502930	0	MMP-9	102,107	MIP-2	78,83	MMP-9	MIP-2	81687(Tax:10116)	114105(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Effect of rutin on spinal_cord_injury through inhibition of the expression of MIP-2 and activation of MMP-9 , and downregulation of Akt phosphorylation .
10820278	0	MMP-9	111,116	MMP-1	87,92	MMP-9	MMP-1	4318	4312	Gene	Gene	production|compound|START_ENTITY decreasing|dobj|production matrix_metalloproteinase-1|ccomp|decreasing matrix_metalloproteinase-1|dep|END_ENTITY	Th2 cell membrane factors in association with IL-4 enhance matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- while decreasing MMP-9 production by granulocyte-macrophage_colony-stimulating_factor-differentiated human monocytes .
11119537	0	MMP-9	97,102	MMP-1	123,128	MMP-9	MMP-1	4318	4312	Gene	Gene	matrix_metalloproteinase_gelatinase_B|appos|START_ENTITY matrix_metalloproteinase_gelatinase_B|appos|END_ENTITY	Borrelia spirochetes upregulate release and activation of matrix_metalloproteinase_gelatinase_B -LRB- MMP-9 -RRB- and collagenase 1 -LRB- MMP-1 -RRB- in human cells .
11478691	0	MMP-9	28,33	MMP-1	14,19	MMP-9	MMP-1	4318	4312	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Evaluation of MMP-1 , MMP-8 , MMP-9 serum levels in patients with adrenal_tumors prior to and after surgery .
16786739	0	MMP-9	68,73	MMP-1	54,59	MMP-9	MMP-1	4318	4312	Gene	Gene	MMP-13|dep|START_ENTITY END_ENTITY|dep|MMP-13	-LSB- Correlations between serum matrix metalloproteinase -LRB- MMP-1 , MMP-3 , MMP-9 , MMP-13 -RRB- concentrations and markers of disease activity in early rheumatoid_arthritis -RSB- .
16970595	0	MMP-9	85,90	MMP-1	54,59	MMP-9	MMP-1	4318	4312	Gene	Gene	acid|amod|START_ENTITY combining|advcl|acid combining|dobj|END_ENTITY	Longitudinal evaluation of a fibrosis index combining MMP-1 and PIIINP compared with MMP-9 , TIMP-1 and hyaluronic acid in patients with chronic hepatitis_C treated by interferon-alpha and ribavirin .
19317417	0	MMP-9	9,14	MMP-10	35,41	MMP-9	MMP-10	4318	4319	Gene	Gene	START_ENTITY|dep|up-regulation up-regulation|compound|END_ENTITY	Vascular MMP-9 / TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke : a combined laser microdissection and protein array study .
19929954	0	MMP-9	128,133	MMP-13	121,127	MMP-9	MMP-13	4318	4322	Gene	Gene	cascade|compound|START_ENTITY cascade|compound|END_ENTITY	Proteolytic roles of matrix metalloproteinase -LRB- MMP -RRB- -13 during progression of chronic_periodontitis : initial evidence for MMP-13 / MMP-9 activation cascade .
20407279	0	MMP-9	23,28	MMP-13	46,52	MMP-9	MMP-13	17395(Tax:10090)	17386(Tax:10090)	Gene	Gene	gelatinase|appos|START_ENTITY gelatinase|appos|END_ENTITY	Absence of gelatinase -LRB- MMP-9 -RRB- or collagenase -LRB- MMP-13 -RRB- attenuates adriamycin-induced albuminuria and glomerulosclerosis .
15144129	0	MMP-9	7,12	MMP-2	0,5	MMP-9	MMP-2	4318	4313	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	MMP-2 , MMP-9 , TIMP-1 and TIMP-2 levels in patients with rheumatoid_arthritis and psoriatic_arthritis .
15556929	0	MMP-9	28,33	MMP-2	36,41	MMP-9	MMP-2	4318	4313	Gene	Gene	Matrix_metalloproteinase-9|appos|START_ENTITY Matrix_metalloproteinase-9|appos|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- , MMP-2 , and serum elastase activity are associated with systolic_hypertension and arterial stiffness .
18540849	0	MMP-9	89,94	MMP-2	113,118	MMP-9	MMP-2	4318	4313	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Culture of human A375 melanoma cells in the presence of fibronectin causes expression of MMP-9 and activation of MMP-2 in culture supernatants .
20137537	0	MMP-9	95,100	MMP-2	83,88	MMP-9	MMP-2	81687(Tax:10116)	81686(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY Effects|appos|mRNA Effects|appos|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effects of losartan and simvastatin on collagen content , myocardial expression of MMP-2 mRNA , MMP-9 mRNA and TIMP-1 mRNA , TIMP-2 mRNA in pressure overload rat hearts -RSB- .
25806956	0	MMP-9	82,87	MMP-2	75,80	MMP-9	MMP-2	4318	4313	Gene	Gene	RANK/RANKL|appos|START_ENTITY RANK/RANKL|compound|END_ENTITY	Correction : Olmesartan Decreased Levels of IL-1b and TNF-a , Down-Regulated MMP-2 , MMP-9 , COX-2 , RANK/RANKL and Up-Regulated SOCs-1 in an Intestinal Mucositis Model .
9561025	0	MMP-9	125,130	MMP-2	119,124	MMP-9	MMP-2	17395(Tax:10090)	17390(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
11478691	0	MMP-9	28,33	MMP-8	21,26	MMP-9	MMP-8	4318	4317	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	Evaluation of MMP-1 , MMP-8 , MMP-9 serum levels in patients with adrenal_tumors prior to and after surgery .
24099107	0	MMP-9	31,36	MMP-8	25,30	MMP-9	MMP-8	4318	4317	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Regulatory expression of MMP-8 / MMP-9 and inhibition of proliferation , migration and invasion in human lung_cancer A549 cells in the presence of HGF variants .
19353331	0	MMP-9	23,28	MMP-9	46,51	MMP-9	MMP-9	4318	4318	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of MMP-9 and imbalance of MMP-9 / TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol .
19353331	0	MMP-9	46,51	MMP-9	23,28	MMP-9	MMP-9	4318	4318	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of MMP-9 and imbalance of MMP-9 / TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol .
10995877	0	MMP-9	48,53	MT1-MMP	55,62	MMP-9	MT1-MMP	4318	4323	Gene	Gene	MMP-2|dep|START_ENTITY MMP-2|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
22232712	0	MMP-9	62,67	MUC5B	41,46	MMP-9	MUC5B	4318	727897	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells .
15585220	0	MMP-9	47,52	Macrophage_migration_inhibitory_factor	0,38	MMP-9	Macrophage migration inhibitory factor	4318	4282	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor induces MMP-9 expression : implications for destabilization of human atherosclerotic_plaques .
17316137	0	MMP-9	47,52	Macrophage_migration_inhibitory_factor	0,38	MMP-9	Macrophage migration inhibitory factor	17395(Tax:10090)	17319(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway .
26713823	0	MMP-9	40,45	Matrix_Metalloproteinase-9	12,38	MMP-9	Matrix Metalloproteinase-9	4318	4318	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Matrix_Metalloproteinase-9 -LRB- MMP-9 -RRB- as a Prognostic Factor in Epithelial and Lymphatic Neoplasia .
15736480	0	MMP-9	28,33	Matrix_metalloproteinase-9	0,26	MMP-9	Matrix metalloproteinase-9	4318	4318	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- immunoreactive protein has modest prognostic value in locally advanced breast_carcinoma patients treated with an adjuvant antiestrogen therapy .
20298757	0	MMP-9	28,33	Matrix_metalloproteinase-9	0,26	MMP-9	Matrix metalloproteinase-9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression and extracellular_signal-regulated_kinase_1_and_2 -LRB- ERK1/2 -RRB- activation in exercise-reduced neuronal apoptosis after stroke .
15316122	0	MMP-9	28,33	Matrix_metalloproteinase_9	0,26	MMP-9	Matrix metalloproteinase 9	4318	4318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- gene polymorphism and MMP-9 plasma levels in primary_Sjogren 's _ syndrome .
25000305	0	MMP-9	35,40	NF-kB	68,73	MMP-9	NF-kB	4318	4790	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|advcl|blocking blocking|dobj|activation activation|amod|END_ENTITY	Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kB activation through MAPK signaling pathways in MCF-7 human breast_carcinoma cells .
17052690	0	MMP-9	37,42	NF-kappaB	70,79	MMP-9	NF-kappaB	4318	4790	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|advcl|blocking blocking|dobj|activation activation|amod|END_ENTITY	Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human_aortic_smooth_muscle_cells .
18345028	0	MMP-9	39,44	NF-kappaB	76,85	MMP-9	NF-kappaB	4318	4790	Gene	Gene	activity|compound|START_ENTITY inducing|dobj|activity inducing|nmod|activation activation|nmod|END_ENTITY	Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1 .
20082219	0	MMP-9	95,100	NF-kappaB	66,75	MMP-9	NF-kappaB	4318	4790	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression .
20093109	0	MMP-9	44,49	NF-kappaB	31,40	MMP-9	NF-kappaB	4318	4790	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2 - -LRB- 4-bromophenyl -RRB- _ ethyl_caffeamide in human monocytic cells .
18181170	0	MMP-9	55,60	NF-kappabeta	79,91	MMP-9	NF-kappabeta	17395(Tax:10090)	18033(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Cytochrome P450 -LRB- CYP -RRB- 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia .
23478276	0	MMP-9	8,13	NGAL	14,18	MMP-9	NGAL	4318	3934	Gene	Gene	ratio|dep|START_ENTITY ratio|amod|END_ENTITY	Urinary MMP-9 / NGAL ratio as a potential marker of FSGS in nephrotic children .
25064356	0	MMP-9	95,100	Nur77	24,29	MMP-9	Nur77	4318	3164	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Orphan nuclear receptor Nur77 promotes colorectal_cancer_invasion and metastasis by regulating MMP-9 and E-cadherin .
20434371	0	MMP-9	28,33	PARP-1	18,24	MMP-9	PARP-1	17395(Tax:10090)	11545(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated_cardiomyopathy .
12947137	0	MMP-9	14,19	PPARgamma	34,43	MMP-9	PPARgamma	4318	5468	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of MMP-9 expression by PPARgamma activators in human bronchial epithelial cells .
16651437	0	MMP-9	180,185	RANK_ligand	168,179	MMP-9	RANK ligand	4318	8600	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB -LRB- RANK -RRB- / RANK_ligand / MMP-9 signaling in prostate_cancer .
26261088	0	MMP-9	0,5	RECK	6,10	MMP-9	RECK	4318	8434	Gene	Gene	Imbalance|compound|START_ENTITY Imbalance|compound|END_ENTITY	MMP-9 / RECK Imbalance : A Mechanism Associated with High-Grade Cervical Lesions_and_Genital_Infection_by_Human_Papillomavirus and Chlamydia_trachomatis .
26261088	0	MMP-9	0,5	RECK	6,10	MMP-9	RECK	4318	8434	Gene	Gene	Imbalance|compound|START_ENTITY Imbalance|compound|END_ENTITY	MMP-9 / RECK Imbalance : A Mechanism Associated with High-Grade Cervical Lesions_and_Genital_Infection_by_Human_Papillomavirus and Chlamydia_trachomatis .
17222798	0	MMP-9	33,38	RRM2	0,4	MMP-9	RRM2	4318	6241	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness .
14644158	0	MMP-9	13,18	RhoA	0,4	MMP-9	RhoA	4318	387	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion .
21557327	0	MMP-9	17,22	Rictor	0,6	MMP-9	Rictor	4318	253260	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells .
22519702	0	MMP-9	19,24	SP-1	0,4	MMP-9	SP-1	4318	6667	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	SP-1 regulation of MMP-9 expression requires Ser586 in the PEST domain .
20975318	0	MMP-9	68,73	SPARC	99,104	MMP-9	SPARC	4318	6678	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Ukrain affects pancreas cancer cell phenotype in vitro by targeting MMP-9 and intra - / extracellular SPARC expression .
17460244	0	MMP-9	107,112	Sp1	82,85	MMP-9	Sp1	4318	6667	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells .
21577212	0	MMP-9	42,47	TGF-b	28,33	MMP-9	TGF-b	4318	7040	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Absence of Thy-1 results in TGF-b induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts .
24280647	0	MMP-9	55,60	TGF-b	88,93	MMP-9	TGF-b	17395(Tax:10090)	21803(Tax:10090)	Gene	Gene	Restoration|nmod|START_ENTITY Restoration|parataxis|critical critical|nsubj|activation activation|nmod|END_ENTITY	Restoration of intrahepatic regulatory T cells through MMP-9 / 13-dependent activation of TGF-b is critical for immune homeostasis following acute liver_injury .
25825495	0	MMP-9	43,48	TGF-b	119,124	MMP-9	TGF-b	4318	7040	Gene	Gene	Matrix_Metalloproteinase-9|appos|START_ENTITY Recruitment|nmod|Matrix_Metalloproteinase-9 triggers|nsubj|Recruitment triggers|dobj|activation activation|amod|END_ENTITY	Recruitment of Matrix_Metalloproteinase-9 -LRB- MMP-9 -RRB- to the fibroblast cell surface by Lysyl_Hydroxylase-3 -LRB- LH3 -RRB- triggers TGF-b activation and fibroblast differentiation .
24993912	0	MMP-9	11,16	TIMP	17,21	MMP-9	TIMP	4318	7076	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	Low sputum MMP-9 / TIMP ratio is associated with airway narrowing in smokers with asthma .
10810401	0	MMP-9	82,87	TIMP-1	141,147	MMP-9	TIMP-1	4318	7076	Gene	Gene	MMP-2|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-2 matrix_metalloproteinases|appos|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10919715	0	MMP-9	132,137	TIMP-1	185,191	MMP-9	TIMP-1	4318	7076	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY matrix_metalloproteinase-9|appos|END_ENTITY	Infiltrative capacity of T_leukemia cell lines : a distinct functional property coupled to expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- .
10995877	0	MMP-9	48,53	TIMP-1	86,92	MMP-9	TIMP-1	4318	7076	Gene	Gene	MMP-2|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-2 matrix_metalloproteinases|appos|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
11118636	0	MMP-9	7,12	TIMP-1	0,6	MMP-9	TIMP-1	4318	7076	Gene	Gene	imbalance|compound|START_ENTITY END_ENTITY|dep|imbalance	TIMP-1 / MMP-9 imbalance in an EBV-immortalized B lymphocyte cellular model : evidence for TIMP-1 multifunctional properties .
11118636	0	MMP-9	7,12	TIMP-1	88,94	MMP-9	TIMP-1	4318	7076	Gene	Gene	imbalance|compound|START_ENTITY imbalance|dep|evidence evidence|nmod|properties properties|compound|END_ENTITY	TIMP-1 / MMP-9 imbalance in an EBV-immortalized B lymphocyte cellular model : evidence for TIMP-1 multifunctional properties .
11471571	0	MMP-9	79,84	TIMP-1	144,150	MMP-9	TIMP-1	4318	7076	Gene	Gene	matrix_metalloproteinase-9|dep|START_ENTITY tissue_inhibitor_of_metalloproteinase-1|amod|matrix_metalloproteinase-9 tissue_inhibitor_of_metalloproteinase-1|appos|END_ENTITY	All trans-retinoic_acid selectively down-regulates matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and up-regulates tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in human bronchoalveolar lavage cells .
12014920	0	MMP-9	122,127	TIMP-1	58,64	MMP-9	TIMP-1	100008993(Tax:9986)	100009047(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY imbalance|nmod|expression _|nsubj|imbalance induces|parataxis|_ induces|dobj|expression expression|nmod|END_ENTITY	Platelet-activating factor induces the gene expression of TIMP-1 , -2 , and PAI-1 : imbalance between the gene expression of MMP-9 and TIMP-1_and _ -2 .
12525717	0	MMP-9	15,20	TIMP-1	21,27	MMP-9	TIMP-1	4318	7076	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	IFNbeta lowers MMP-9 / TIMP-1 ratio , which predicts new enhancing lesions in patients with SPMS .
12576963	0	MMP-9	45,50	TIMP-1	107,113	MMP-9	TIMP-1	4318	7076	Gene	Gene	metalloproteinases|dep|START_ENTITY Imbalance|nmod|metalloproteinases Imbalance|dep|END_ENTITY	Imbalance between matrix metalloproteinases -LRB- MMP-9 and MMP-2 -RRB- and tissue inhibitors of metalloproteinases -LRB- TIMP-1 and TIMP-2 -RRB- in acute_respiratory_distress_syndrome patients .
14569458	0	MMP-9	35,40	TIMP-1	18,24	MMP-9	TIMP-1	17395(Tax:10090)	21857(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic_mice .
14971882	0	MMP-9	55,60	TIMP-1	114,120	MMP-9	TIMP-1	4318	7076	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY matrix_metalloproteinase-9|appos|END_ENTITY	Determination of the serum matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_matrix_metalloproteinase-1 -LRB- TIMP-1 -RRB- in patients with either advanced small-cell lung_cancer or non-small-cell lung_cancer prior to treatment .
15015006	0	MMP-9	66,71	TIMP-1	123,129	MMP-9	TIMP-1	4318	7076	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY matrix_metalloproteinase-9|appos|END_ENTITY	Effect of interferon beta-1a on serum matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_matrix_metalloproteinase -LRB- TIMP-1 -RRB- in relapsing remitting multiple_sclerosis patients .
15291899	0	MMP-9	35,40	TIMP-1	42,48	MMP-9	TIMP-1	4318	7076	Gene	Gene	flunisolide|nmod|START_ENTITY effects|nmod|flunisolide isolated|nmod|effects isolated|nsubj|release release|compound|END_ENTITY	In vitro effects of flunisolide on MMP-9 , TIMP-1 , fibronectin , TGF-beta1 release and apoptosis in sputum cells freshly isolated from mild to moderate asthmatics .
15810979	0	MMP-9	16,21	TIMP-1	22,28	MMP-9	TIMP-1	17395(Tax:10090)	21857(Tax:10090)	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Upregulation of MMP-9 / TIMP-1 enzymatic system in eosinophilic_meningitis caused by Angiostrongylus_cantonensis .
16042227	0	MMP-9	6,11	TIMP-1	12,18	MMP-9	TIMP-1	4318	7076	Gene	Gene	ratios|dep|START_ENTITY ratios|amod|END_ENTITY	Serum MMP-9 / TIMP-1 and MMP-2 / TIMP-2 ratios in multiple_sclerosis : relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment .
16257222	0	MMP-9	88,93	TIMP-1	94,100	MMP-9	TIMP-1	4318	7076	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	In bacterial_meningitis cortical brain_damage is associated with changes in parenchymal MMP-9 / TIMP-1 ratio and increased collagen type IV degradation .
16374054	0	MMP-9	79,84	TIMP-1	72,78	MMP-9	TIMP-1	17395(Tax:10090)	21857(Tax:10090)	Gene	Gene	TIMP-2|amod|START_ENTITY MMP-2|dep|TIMP-2 MMP-2|compound|END_ENTITY	rd1 mouse retina shows imbalance in cellular distribution and levels of TIMP-1 / MMP-9 , TIMP-2 / MMP-2 and sulfated glycosaminoglycans .
16412833	0	MMP-9	28,33	TIMP-1	85,91	MMP-9	TIMP-1	4318	7076	Gene	Gene	Matrix_metalloproteinase-9|appos|START_ENTITY Matrix_metalloproteinase-9|appos|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinase -LRB- TIMP-1 -RRB- in patients with relapsing-remitting multiple_sclerosis treated with interferon beta .
16916326	0	MMP-9	114,119	TIMP-1	120,126	MMP-9	TIMP-1	17395(Tax:10090)	21857(Tax:10090)	Gene	Gene	/|dep|START_ENTITY /|dobj|balance balance|compound|END_ENTITY	Overexpression of nitric_oxide synthase by the endothelium attenuates bleomycin-induced lung_fibrosis and impairs MMP-9 / TIMP-1 balance .
17184595	0	MMP-9	48,53	TIMP-1	54,60	MMP-9	TIMP-1	4318	7076	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Simvastatin could prevent increase of the serum MMP-9 / TIMP-1 ratio in acute ischaemic_stroke .
17251814	0	MMP-9	34,39	TIMP-1	90,96	MMP-9	TIMP-1	4318	7076	Gene	Gene	MMP-8|dep|START_ENTITY metalloproteinases|appos|MMP-8 inhibitors|nsubj|metalloproteinases inhibitors|nmod|metalloproteinases metalloproteinases|appos|END_ENTITY	Matrix metalloproteinases -LRB- MMP-8 , MMP-9 -RRB- and the tissue inhibitors of metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in patients with fungal_keratitis .
17879211	0	MMP-9	42,47	TIMP-1	88,94	MMP-9	TIMP-1	4318	7076	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic_nephropathy .
17976016	0	MMP-9	7,12	TIMP-1	25,31	MMP-9	TIMP-1	4318	7076	Gene	Gene	bound|nsubjpass|START_ENTITY bound|nmod|END_ENTITY	Latent MMP-9 is bound to TIMP-1 before secretion .
18850474	0	MMP-9	42,47	TIMP-1	99,105	MMP-9	TIMP-1	4318	7076	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY Expression|nmod|matrix_metalloproteinase-9 Expression|appos|END_ENTITY	Expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinase -LRB- TIMP-1 -RRB- in tissues with a diagnosis of childhood_lymphoma .
18945772	0	MMP-9	48,53	TIMP-1	54,60	MMP-9	TIMP-1	17395(Tax:10090)	7076	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	Infection with human_cytomegalovirus alters the MMP-9 / TIMP-1 balance in human macrophages .
19235898	0	MMP-9	47,52	TIMP-1	9,15	MMP-9	TIMP-1	4318	7076	Gene	Gene	secretion|compound|START_ENTITY accompanies|dobj|secretion accompanies|nsubj|release release|compound|END_ENTITY	Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment .
19353331	0	MMP-9	23,28	TIMP-1	52,58	MMP-9	TIMP-1	4318	7076	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|associated associated|nsubjpass|END_ENTITY	Abnormal expression of MMP-9 and imbalance of MMP-9 / TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol .
19353331	0	MMP-9	46,51	TIMP-1	52,58	MMP-9	TIMP-1	4318	7076	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|associated associated|nsubjpass|END_ENTITY	Abnormal expression of MMP-9 and imbalance of MMP-9 / TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol .
19608737	0	MMP-9	11,16	TIMP-1	44,50	MMP-9	TIMP-1	4318	7076	Gene	Gene	proenzyme|compound|START_ENTITY proenzyme|amod|unencumbered unencumbered|nmod|END_ENTITY	Neutrophil MMP-9 proenzyme , unencumbered by TIMP-1 , undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast_growth_factor -LRB- FGF-2 -RRB- / FGFR-2 pathway .
19728856	0	MMP-9	69,74	TIMP-1	129,135	MMP-9	TIMP-1	4318	7076	Gene	Gene	matrix_metalloproteinase_9|appos|START_ENTITY serum|nmod|matrix_metalloproteinase_9 metalloproteinases|nsubj|serum metalloproteinases|dobj|1 1|appos|END_ENTITY	Pre-treatment serum and plasma levels of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinases 1 -LRB- TIMP-1 -RRB- in gastric_cancer patients .
19847138	0	MMP-9	19,24	TIMP-1	60,66	MMP-9	TIMP-1	4318	7076	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|TIMP-2 TIMP-2|compound|END_ENTITY	Metalloproteinases MMP-9 , MMP-2 and their tissue inhibitors TIMP-1 , TIMP-2 in peripheral transbronchial lung biopsies of patients with sarcoidosis .
19889076	0	MMP-9	40,45	TIMP-1	52,58	MMP-9	TIMP-1	4318	7076	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|parataxis|have have|nsubj|372 372|compound|END_ENTITY	Host single nucleotide polymorphisms of MMP-9 -1562 / TIMP-1 372 have gender differences in the risk of gastric_intestinal_metaplasia after Helicobacter_pylori_infection .
19927649	0	MMP-9	33,38	TIMP-1	39,45	MMP-9	TIMP-1	4318	7076	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of SiO2 on expression of MMP-9 / TIMP-1 in human alveolar macrophages in vitro -RSB- .
20030715	0	MMP-9	0,5	TIMP-1	6,12	MMP-9	TIMP-1	4318	7076	Gene	Gene	START_ENTITY|appos|induced induced|nsubj|imbalance imbalance|compound|END_ENTITY	MMP-9 / TIMP-1 imbalance induced in human dendritic cells by Porphyromonas_gingivalis .
20801641	0	MMP-9	42,47	TIMP-1	95,101	MMP-9	TIMP-1	4318	7076	Gene	Gene	matrix_metalloproteinase_9|appos|START_ENTITY matrix_metalloproteinase_9|appos|END_ENTITY	Expression of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_metalloproteinases_1 -LRB- TIMP-1 -RRB- by colorectal_cancer cells and adjacent stroma cells -- associations with histopathology and patients outcome .
20840538	0	MMP-9	114,119	TIMP-1	120,126	MMP-9	TIMP-1	81687(Tax:10116)	116510(Tax:10116)	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	KMUP-3 attenuates ventricular remodelling after myocardial_infarction through eNOS enhancement and restoration of MMP-9 / TIMP-1 balance .
20854798	0	MMP-9	48,53	TIMP-1	54,60	MMP-9	TIMP-1	81687(Tax:10116)	116510(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY modulation|dep|system system|compound|END_ENTITY	Differential modulation of the cytokine-induced MMP-9 / TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin .
21963718	0	MMP-9	58,63	TIMP-1	64,70	MMP-9	TIMP-1	4318	7076	Gene	Gene	equilibrium|compound|START_ENTITY equilibrium|compound|END_ENTITY	Thioredoxin stimulates MMP-9 expression , de-regulates the MMP-9 / TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231_breast_cancer cells .
21993004	0	MMP-9	21,26	TIMP-1	27,33	MMP-9	TIMP-1	4318	7076	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Tamoxifen lowers the MMP-9 / TIMP-1 ratio and inhibits the invasion capacity of ER-positive non-small cell lung_cancer cells .
22020222	0	MMP-9	69,74	TIMP-1	10,16	MMP-9	TIMP-1	4318	7076	Gene	Gene	activity|compound|START_ENTITY assessment|nmod|activity correlates|nmod|assessment correlates|nsubj|ratio ratio|compound|END_ENTITY	Pro-MMP-9 / TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity .
22139647	0	MMP-9	0,5	TIMP-1	28,34	MMP-9	TIMP-1	4318	7076	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|due due|nmod|underexpression underexpression|compound|END_ENTITY	MMP-9 overexpression due to TIMP-1 and RECK underexpression is associated with prognosis in prostate_cancer .
22438979	0	MMP-9	4,9	TIMP-1	10,16	MMP-9	TIMP-1	17395(Tax:10090)	21857(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|axis axis|compound|END_ENTITY	The MMP-9 / TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration .
23131422	0	MMP-9	15,20	TIMP-1	21,27	MMP-9	TIMP-1	4318	7076	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Elevated serum MMP-9 / TIMP-1 ratio in patients with homozygous familial_hypercholesterolemia : effects of LDL-apheresis .
23792071	0	MMP-9	25,30	TIMP-1	48,54	MMP-9	TIMP-1	4318	7076	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	The circulating level of MMP-9 and its ratio to TIMP-1 as a predictor of severity in patients with community-acquired_pneumonia .
24330623	0	MMP-9	21,26	TIMP-1	27,33	MMP-9	TIMP-1	4318	7076	Gene	Gene	levels|nmod|START_ENTITY levels|dep|complex complex|compound|END_ENTITY	Plasma levels of the MMP-9 : TIMP-1 complex as prognostic biomarker in breast_cancer : a retrospective study .
24340960	0	MMP-9	46,51	TIMP-1	53,59	MMP-9	TIMP-1	4318	7076	Gene	Gene	MMP-2|dep|START_ENTITY MMP-2|dep|END_ENTITY	-LSB- Indices of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , TIMP-1 -RRB- with juvenile_arthritis in children -RSB- .
24727739	0	MMP-9	70,75	TIMP-1	63,69	MMP-9	TIMP-1	4318	7076	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Association of sepsis-related mortality with early increase of TIMP-1 / MMP-9 ratio .
24727739	3	MMP-9	498,503	TIMP-1	491,497	MMP-9	TIMP-1	4318	7076	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	2 -RRB- Is there an association between TIMP-1 / MMP-9 ratio and sepsis severity and mortality during such period ?
25330860	0	MMP-9	80,85	TIMP-1	86,92	MMP-9	TIMP-1	81687(Tax:10116)	116510(Tax:10116)	Gene	Gene	Balance|compound|START_ENTITY Balance|compound|END_ENTITY	Resveratrol Attenuates the Blood-Brain Barrier Dysfunction by Regulation of the MMP-9 / TIMP-1 Balance after Cerebral_Ischemia Reperfusion in Rats .
25441368	0	MMP-9	48,53	TIMP-1	77,83	MMP-9	TIMP-1	4318	7076	Gene	Gene	MMP-2|dep|START_ENTITY Matrix_Metalloproteinases|appos|MMP-2 Matrix_Metalloproteinases|appos|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
26570691	0	MMP-9	38,43	TIMP-1	45,51	MMP-9	TIMP-1	4318	7076	Gene	Gene	MRPROANP|compound|START_ENTITY MRPROANP|appos|END_ENTITY	1030 : BIOMARKERS IN PEDIATRIC SEPSIS : MMP-9 , TIMP-1 , MRPROANP , AND ADIPOCYTE_FATTY-ACID_BINDING_PROTEIN .
26626455	0	MMP-9	15,20	TIMP-1	24,30	MMP-9	TIMP-1	4318	7076	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Association of MMP-9 to TIMP-1 ratio with long-term body weight and waist circumference after dietary weight reduction in men with metabolic_syndrome .
9300240	0	MMP-9	52,57	TIMP-1	104,110	MMP-9	TIMP-1	81687(Tax:10116)	116510(Tax:10116)	Gene	Gene	gelatinase_B|appos|START_ENTITY gelatinase_B|appos|END_ENTITY	Differential regulation of glomerular gelatinase_B -LRB- MMP-9 -RRB- and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in obese Zucker rats .
9561025	0	MMP-9	125,130	TIMP-1	94,100	MMP-9	TIMP-1	17395(Tax:10090)	21857(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression stimulation|nmod|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
10810401	0	MMP-9	82,87	TIMP-2	149,155	MMP-9	TIMP-2	4318	7077	Gene	Gene	MMP-2|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-2 matrix_metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10995877	0	MMP-9	48,53	TIMP-2	94,100	MMP-9	TIMP-2	4318	7077	Gene	Gene	MMP-2|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-2 matrix_metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
16042227	0	MMP-9	6,11	TIMP-2	29,35	MMP-9	TIMP-2	4318	7077	Gene	Gene	ratios|dep|START_ENTITY ratios|compound|END_ENTITY	Serum MMP-9 / TIMP-1 and MMP-2 / TIMP-2 ratios in multiple_sclerosis : relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment .
17251814	0	MMP-9	34,39	TIMP-2	98,104	MMP-9	TIMP-2	4318	7077	Gene	Gene	MMP-8|dep|START_ENTITY metalloproteinases|appos|MMP-8 inhibitors|nsubj|metalloproteinases inhibitors|nmod|metalloproteinases metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Matrix metalloproteinases -LRB- MMP-8 , MMP-9 -RRB- and the tissue inhibitors of metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in patients with fungal_keratitis .
19141395	0	MMP-9	32,37	TIMP-2	57,63	MMP-9	TIMP-2	4318	7077	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|expression expression|compound|END_ENTITY	Immunohistochemical analysis of MMP-9 , MMP-2 and TIMP-1 , TIMP-2 expression in the central nervous system following infection with viral and bacterial_meningitis .
19317417	0	MMP-9	9,14	TIMP-2	15,21	MMP-9	TIMP-2	4318	7077	Gene	Gene	START_ENTITY|dep|up-regulation up-regulation|compound|END_ENTITY	Vascular MMP-9 / TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke : a combined laser microdissection and protein array study .
19847138	0	MMP-9	19,24	TIMP-2	68,74	MMP-9	TIMP-2	4318	7077	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	Metalloproteinases MMP-9 , MMP-2 and their tissue inhibitors TIMP-1 , TIMP-2 in peripheral transbronchial lung biopsies of patients with sarcoidosis .
20137537	0	MMP-9	95,100	TIMP-2	123,129	MMP-9	TIMP-2	81687(Tax:10116)	29543(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY Effects|appos|mRNA Effects|appos|mRNA mRNA|compound|END_ENTITY	-LSB- Effects of losartan and simvastatin on collagen content , myocardial expression of MMP-2 mRNA , MMP-9 mRNA and TIMP-1 mRNA , TIMP-2 mRNA in pressure overload rat hearts -RSB- .
23320481	0	MMP-9	37,42	TIMP-2	53,59	MMP-9	TIMP-2	4318	7077	Gene	Gene	metalloproteinase|amod|START_ENTITY Circulating|dobj|metalloproteinase complex|dep|Circulating complex|compound|END_ENTITY	Circulating matrix metalloproteinase MMP-9 and MMP-2 / TIMP-2 complex are associated with spontaneous early_pregnancy_failure .
25441368	0	MMP-9	48,53	TIMP-2	85,91	MMP-9	TIMP-2	4318	7077	Gene	Gene	MMP-2|dep|START_ENTITY Matrix_Metalloproteinases|appos|MMP-2 Matrix_Metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
26823777	0	MMP-9	14,19	TIMP-2	20,26	MMP-9	TIMP-2	4318	7077	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of MMP-9 / TIMP-2 in nasal_polyps and its functional implications .
21320567	0	MMP-9	14,19	TNF-a	83,88	MMP-9	TNF-a	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|signaling signaling|compound|END_ENTITY	Regulation of MMP-9 expression by the A2b_adenosine_receptor and its dependency on TNF-a signaling .
22440312	0	MMP-9	161,166	TNF-a	146,151	MMP-9	TNF-a	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	115 kDa serine protease confers sustained protection to visceral_leishmaniasis caused by Leishmania_donovani via IFN-y induced down-regulation of TNF-a mediated MMP-9 activity .
22572236	0	MMP-9	58,63	TNF-a	15,20	MMP-9	TNF-a	282871(Tax:9913)	280943(Tax:9913)	Gene	Gene	release|amod|START_ENTITY pathway|nmod|release pathway|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of TNF-a and MAPK pathway in the intramammary MMP-9 release via degranulation of cow neutrophils during acute mammary gland involution .
22820188	0	MMP-9	108,113	TNF-a	0,5	MMP-9	TNF-a	4318	7124	Gene	Gene	expression|appos|START_ENTITY inducing|dobj|expression migration|acl|inducing epithelial|dep|migration promotes|nsubj|epithelial promotes|dep|END_ENTITY	TNF-a promotes human retinal pigment epithelial -LRB- RPE -RRB- cell migration by inducing matrix_metallopeptidase_9 -LRB- MMP-9 -RRB- expression through activation of Akt/mTORC1 signaling .
24200302	0	MMP-9	45,50	TNF-a	10,15	MMP-9	TNF-a	4318	7124	Gene	Gene	production|nmod|START_ENTITY suppresses|dobj|production suppresses|nsubj|END_ENTITY	Targeting TNF-a suppresses the production of MMP-9 in human salivary gland cells .
24667088	0	MMP-9	8,13	TNF-a	94,99	MMP-9	TNF-a	282871(Tax:9913)	280943(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of MMP-9 in the breakdown of barrier integrity of the corneal endothelium in response to TNF-a .
25889878	0	MMP-9	26,31	TNF-a	12,17	MMP-9	TNF-a	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
25889878	0	MMP-9	26,31	TNF-a	12,17	MMP-9	TNF-a	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
11704541	0	MMP-9	13,18	TNF-alpha	65,74	MMP-9	TNF-alpha	4318	7124	Gene	Gene	Induction|nmod|START_ENTITY epithelial|nsubj|Induction epithelial|nmod|END_ENTITY	Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa_B-mediated pathway .
14516792	0	MMP-9	69,74	TNF-alpha	96,105	MMP-9	TNF-alpha	4318	7124	Gene	Gene	secretion|compound|START_ENTITY secretion|acl|induced induced|nmod|END_ENTITY	The inhibition of MAPK pathway is correlated with down-regulation of MMP-9 secretion induced by TNF-alpha in human keratinocytes .
15273742	0	MMP-9	45,50	TNF-alpha	0,9	MMP-9	TNF-alpha	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	alphavbeta6|compound|START_ENTITY expression|nmod|alphavbeta6 regulates|dobj|expression regulates|nsubj|END_ENTITY	TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion .
15458430	0	MMP-9	46,51	TNF-alpha	0,9	MMP-9	TNF-alpha	4318	7124	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells .
15855236	0	MMP-9	58,63	TNF-alpha	81,90	MMP-9	TNF-alpha	4318	7124	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Breast_cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta .
17158602	0	MMP-9	18,23	TNF-alpha	0,9	MMP-9	TNF-alpha	4318	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNF-alpha induces MMP-9 expression via activation of Src/EGFR , PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells .
17890880	0	MMP-9	47,52	TNF-alpha	0,9	MMP-9	TNF-alpha	4318	7124	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	TNF-alpha and IL-1_beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells .
18606251	0	MMP-9	92,97	TNF-alpha	63,72	MMP-9	TNF-alpha	4318	7124	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-alpha and its associated MMP-9 activity and CD44 expression .
18773430	0	MMP-9	154,159	TNF-alpha	174,183	MMP-9	TNF-alpha	4318	7124	Gene	Gene	expression|compound|START_ENTITY expression|nmod|HASMC HASMC|compound|END_ENTITY	3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix_metalloproteinase_9 ; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-alpha induced HASMC .
18824875	0	MMP-9	93,98	TNF-alpha	28,37	MMP-9	TNF-alpha	4318	7124	Gene	Gene	cell|amod|START_ENTITY changes|nmod|cell changes|nsubj|involvement involvement|nmod|END_ENTITY	Nitric_oxide involvement in TNF-alpha and IL-1_beta-mediated changes in human mesangial cell MMP-9 and TIMP-1 .
21502320	0	MMP-9	135,140	TNF-alpha	83,92	MMP-9	TNF-alpha	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY induction|nmod|matrix_metalloproteinase-9 induction|appos|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
9743290	0	MMP-9	23,28	TNF-alpha	43,52	MMP-9	TNF-alpha	4318	7124	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor -LRB- MMPSF -RRB- .
20020446	0	MMP-9	16,21	TNFalpha	36,44	MMP-9	TNFalpha	4318	7124	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin_D .
25889878	0	MMP-9	26,31	TRAF2	74,79	MMP-9	TRAF2	17395(Tax:10090)	22030(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
25889878	0	MMP-9	26,31	TRAF2	74,79	MMP-9	TRAF2	17395(Tax:10090)	22030(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
18834856	0	MMP-9	14,19	TRAIL	0,5	MMP-9	TRAIL	4318	8743	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells .
21963718	0	MMP-9	23,28	Thioredoxin	0,11	MMP-9	Thioredoxin	4318	7295	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Thioredoxin stimulates MMP-9 expression , de-regulates the MMP-9 / TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231_breast_cancer cells .
11360674	0	MMP-9	20,25	Thrombin	0,8	MMP-9	Thrombin	17395(Tax:10090)	14061(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Thrombin stimulates MMP-9 mRNA expression through AP-1 pathway in human mesangial cells .
18336852	0	MMP-9	36,41	Tumor_necrosis_factor-alpha	0,27	MMP-9	Tumor necrosis factor-alpha	4318	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces MMP-9 expression via p42/p44 _ MAPK , JNK , and nuclear factor-kappaB in A549 cells .
16584583	0	MMP-9	38,43	VEGF	22,26	MMP-9	VEGF	4318	7422	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	-LSB- Relationship between VEGF and MMP-2 , MMP-9 in 82 patients with acute_myeloid_leukemia -RSB- .
18691882	0	MMP-9	16,21	VEGF	0,4	MMP-9	VEGF	4318	7422	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal_cancer_angiogenesis .
21442180	0	MMP-9	31,36	VEGF	42,46	MMP-9	VEGF	4318	7422	Gene	Gene	component|nsubj|START_ENTITY component|amod|END_ENTITY	Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic_ductal_adenocarcinoma .
25797250	0	MMP-9	88,93	WIP1	0,4	MMP-9	WIP1	4318	8493	Gene	Gene	inducing|dobj|START_ENTITY stimulates|advcl|inducing stimulates|nsubj|END_ENTITY	WIP1 stimulates migration and invasion of salivary adenoid_cystic_carcinoma by inducing MMP-9 and VEGF-C .
18007068	0	MMP-9	46,51	calcitonin-gene-related_peptide	11,42	MMP-9	calcitonin-gene-related peptide	4318	796	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	-LSB- Effect of calcitonin-gene-related_peptide on MMP-9 production in human bronchial epithelial cells -RSB- .
23271730	0	MMP-9	119,124	extracellular_signal-regulated_kinase	66,103	MMP-9	extracellular signal-regulated kinase	4318	5594	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Interleukin-20 promotes migration of bladder_cancer cells through extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated MMP-9 protein expression leading to nuclear factor -LRB- NF-kB -RRB- activation by inducing the up-regulation of p21 -LRB- WAF1 -RRB- protein expression .
8563023	0	MMP-9	28,33	gelatinase_B	35,47	MMP-9	gelatinase B	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Developmental expression of MMP-9 -LRB- gelatinase_B -RRB- mRNA in mouse embryos .
12874388	0	MMP-9	65,70	integrin_alphavbeta3	10,30	MMP-9	integrin alphavbeta3	4318	3685	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Activated integrin_alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast_cancer cells .
16939904	0	MMP-9	73,78	interleukin-1beta	9,26	MMP-9	interleukin-1beta	4318	3553	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|advcl|regulating	-LSB- Role of interleukin-1beta in regulating human cultured endometrial cell MMP-9 and TIMP-3 expressions in the mid-secretory phase -RSB- .
12062105	0	MMP-9	77,82	kit-ligand	103,113	MMP-9	kit-ligand	17395(Tax:10090)	17311(Tax:10090)	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand .
15333466	0	MMP-9	89,94	matrilysin-2	15,27	MMP-9	matrilysin-2	4318	56547	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|expression expression|amod|END_ENTITY	Association of matrilysin-2 -LRB- MMP-26 -RRB- expression with tumor progression and activation of MMP-9 in esophageal_squamous_cell_carcinoma .
9131273	0	MMP-9	68,73	matrix-metalloproteinase-9	40,66	MMP-9	matrix-metalloproteinase-9	4318	4318	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Sequential production and activation of matrix-metalloproteinase-9 -LRB- MMP-9 -RRB- with breast_cancer progression .
22820188	0	MMP-9	108,113	matrix_metallopeptidase_9	81,106	MMP-9	matrix metallopeptidase 9	4318	4318	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TNF-a promotes human retinal pigment epithelial -LRB- RPE -RRB- cell migration by inducing matrix_metallopeptidase_9 -LRB- MMP-9 -RRB- expression through activation of Akt/mTORC1 signaling .
9325178	0	MMP-9	55,60	matrix_metalloprotease-9	29,53	MMP-9	matrix metalloprotease-9	4318	4318	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and activation of matrix_metalloprotease-9 -LRB- MMP-9 -RRB- by HL-60 promyelocytic_leukemia cells .
10224058	0	MMP-9	42,47	matrix_metalloproteinase-9	14,40	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- via a converging plasmin/stromelysin -1 cascade enhances tumor cell invasion .
11438179	0	MMP-9	105,110	matrix_metalloproteinase-9	77,103	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Development of an ultrasensitive enzyme immunoassay for the determination of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- levels in normal human cerebrospinal fluid .
11529928	0	MMP-9	53,58	matrix_metalloproteinase-9	25,51	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated serum levels of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in Kawasaki_disease .
11912173	0	MMP-9	42,47	matrix_metalloproteinase-9	14,40	MMP-9	matrix metalloproteinase-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by translational efficiency in murine prostate_carcinoma cells .
12929930	0	MMP-9	121,126	matrix_metalloproteinase-9	93,119	MMP-9	matrix metalloproteinase-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- recruits osteoclast precursors by inducing chemotaxis , matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- activity , and collagen transmigration .
16475914	0	MMP-9	37,42	matrix_metalloproteinase-9	9,35	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Systemic matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- levels as prognostic indexes of bone_disease in patients with multiple_myeloma .
16736997	0	MMP-9	79,84	matrix_metalloproteinase-9	51,77	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The C -LRB- -1562 -RRB- T polymorphism in the promoter of the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene and coronary_atherosclerosis -RSB- .
17034838	0	MMP-9	55,60	matrix_metalloproteinase-9	27,53	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in epithelial_ovarian_cancer .
17617834	0	MMP-9	68,73	matrix_metalloproteinase-9	40,66	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Functional -1562 _ C-to-T polymorphism in matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- promoter is associated with the risk for oral_squamous_cell_carcinoma in younger male areca users .
17889183	0	MMP-9	47,52	matrix_metalloproteinase-9	19,45	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Down-regulation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression in the myocardium of congestive_heart_failure patients .
18194081	0	MMP-9	76,81	matrix_metalloproteinase-9	48,74	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphisms in the promoter of the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene are not linked with significant plasma MMP-9 variations in healthy subjects .
19264454	0	MMP-9	59,64	matrix_metalloproteinase-9	31,57	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphism of the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene in schizophrenia .
19626678	0	MMP-9	72,77	matrix_metalloproteinase-9	44,70	MMP-9	matrix metalloproteinase-9	100008993(Tax:9986)	100008993(Tax:9986)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cytokines and signaling pathways regulating matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression in corneal epithelial cells .
19921474	0	MMP-9	55,60	matrix_metalloproteinase-9	27,53	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in stage II colorectal_carcinoma .
20197064	0	MMP-9	55,60	matrix_metalloproteinase-9	27,53	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphism of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene in alcohol_dependence : family and case control study .
20663046	0	MMP-9	60,65	matrix_metalloproteinase-9	32,58	MMP-9	matrix metalloproteinase-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Melatonin inhibits postischemic matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral_ischemia .
21077523	0	MMP-9	42,47	matrix_metalloproteinase-9	14,40	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in human midpregnancy amniotic fluid and risk of preterm_labor .
21175737	0	MMP-9	36,41	matrix_metalloproteinase-9	8,34	MMP-9	matrix metalloproteinase-9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in striatal blood-brain barrier disruption in a 3-nitropropionic_acid model of Huntington 's _ disease .
21437990	0	MMP-9	55,60	matrix_metalloproteinase-9	27,53	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphism of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene and response to lithium prophylaxis in bipolar patients .
22730324	0	MMP-9	59,64	matrix_metalloproteinase-9	31,57	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	A 17-residue sequence from the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- hemopexin domain binds a4b1 integrin and inhibits MMP-9-induced functions in chronic_lymphocytic_leukemia B cells .
22858217	0	MMP-9	44,49	matrix_metalloproteinase-9	16,42	MMP-9	matrix metalloproteinase-9	4318	4318	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increased serum matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- levels in young patients during bipolar_depression .
9706876	0	MMP-9	97,102	matrix_metalloproteinase-9	69,95	MMP-9	matrix metalloproteinase-9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intermittent administration of parathyroid_hormone -LRB- 1-34 -RRB- stimulates matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression in rat long bone .
10935492	0	MMP-9	58,63	matrix_metalloproteinase_9	30,56	MMP-9	matrix metalloproteinase 9	4318	4318	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Transcriptional inhibition of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity by a c-fos/estrogen _ receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion .
11296850	0	MMP-9	57,62	matrix_metalloproteinase_9	29,55	MMP-9	matrix metalloproteinase 9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Chronic vasodilation induces matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- expression during microvascular remodeling in rat skeletal muscle .
11531282	0	MMP-9	49,54	matrix_metalloproteinase_9	21,47	MMP-9	matrix metalloproteinase 9	4318	4318	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of latent matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- predicts survival in advanced ovarian_cancer .
16309207	0	MMP-9	41,46	matrix_metalloproteinase_9	13,39	MMP-9	matrix metalloproteinase 9	4318	4318	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- on the metastatic behavior of oropharyngeal_cancer .
16497166	0	MMP-9	73,78	matrix_metalloproteinase_9	45,71	MMP-9	matrix metalloproteinase 9	4318	4318	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of autocrine TNF-alpha-stimulated matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- expression by mitogen-activated protein kinases in THP-1 monocytic cells .
18777539	0	MMP-9	123,128	matrix_metalloproteinase_9	95,121	MMP-9	matrix metalloproteinase 9	4318	4318	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dynamic contrast-enhanced -LRB- DCE -RRB- derived transfer coefficient -LRB- ktrans -RRB- is a surrogate marker of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- expression in brain_tuberculomas .
18929380	0	MMP-9	51,56	matrix_metalloproteinase_9	23,49	MMP-9	matrix metalloproteinase 9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Increased gelatinase_B / matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity in a murine model of acute coxsackievirus B4-induced pancreatitis .
24344026	0	MMP-9	45,50	matrix_metalloproteinase_9	17,43	MMP-9	matrix metalloproteinase 9	4318	4318	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Determination of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- protein expression in laryngeal_squamous_cell_carcinomas based on digital image analysis .
23443810	0	MMP-9	49,54	miR-21	10,16	MMP-9	miR-21	17395(Tax:10090)	387140(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|advcl|regulating	Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic_nephropathy mice .
25901555	0	MMP-9	112,117	microRNA-15b	81,93	MMP-9	microRNA-15b	4318	406949	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression .
16153722	0	MMP-9	52,57	nucleolin	8,17	MMP-9	nucleolin	4318	4691	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of nucleolin in posttranscriptional control of MMP-9 expression .
11468147	0	MMP-9	35,40	p38	113,116	MMP-9	p38	4318	1432	Gene	Gene	cytopathogenic|amod|START_ENTITY production|amod|cytopathogenic production|acl:relcl|abolished abolished|nmod|inhibition inhibition|nmod|kinase kinase|amod|END_ENTITY	HIV-1 glycoprotein_120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway .
11716547	0	MMP-9	53,58	p38	4,7	MMP-9	p38	4318	1432	Gene	Gene	collagenase|compound|START_ENTITY expression|nmod|collagenase regulates|dobj|expression regulates|nsubj|SAPK SAPK|amod|END_ENTITY	The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation .
14631115	0	MMP-9	51,56	p38	21,24	MMP-9	p38	4318	1432	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line .
15483673	0	MMP-9	61,66	p38	41,44	MMP-9	p38	4318	1432	Gene	Gene	production|compound|START_ENTITY critical|nmod|production critical|nsubj|activation activation|nmod|END_ENTITY	Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells .
18801463	0	MMP-9	40,45	p38	76,79	MMP-9	p38	4318	1432	Gene	Gene	expression|compound|START_ENTITY pathway|nmod|expression pathway|dep|mediation mediation|nmod|MAP MAP|compound|END_ENTITY	Signaling pathway for TNF-alpha-induced MMP-9 expression : mediation through p38 MAP kinase , and inhibition by anti-cancer molecule magnolol in human urinary_bladder_cancer 5637 cells .
19576641	0	MMP-9	23,28	p38	74,77	MMP-9	p38	4318	1432	Gene	Gene	expression|compound|START_ENTITY reduces|dobj|expression reduces|nmod|prevention prevention|nmod|activation activation|amod|END_ENTITY	Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages .
22812390	0	MMP-9	93,98	p38	119,122	MMP-9	p38	4318	1432	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|pathway pathway|amod|END_ENTITY	Fibronectin-a4b1 interactions in hepatic cold ischemia and reperfusion injury : regulation of MMP-9 and MT1-MMP via the p38 MAPK pathway .
22820569	0	MMP-9	36,41	p38	10,13	MMP-9	p38	81687(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY lowers|dobj|expression lowers|nsubj|signal signal|amod|END_ENTITY	-LSB- Blocking p38 signal pathway lowers MMP-9 expression and reduces brain_edema in rats with traumatic_brain_injury -RSB- .
23229870	0	MMP-9	20,25	p38	53,56	MMP-9	p38	4318	1432	Gene	Gene	migration|compound|START_ENTITY migration|nmod|kinase kinase|amod|END_ENTITY	Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells .
23468369	0	MMP-9	47,52	p38	15,18	MMP-9	p38	4318	1432	Gene	Gene	enhancement|compound|START_ENTITY MAPK|nmod|enhancement MAPK|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes .
24819308	0	MMP-9	58,63	p38	83,86	MMP-9	p38	4318	1432	Gene	Gene	expression|compound|START_ENTITY invasion|nmod|expression enhances|dobj|invasion enhances|nmod|pathway pathway|amod|END_ENTITY	SDF-1 / CXCR7 axis enhances ovarian_cancer cell invasion by MMP-9 expression through p38 MAPK pathway .
25449697	0	MMP-9	25,30	p38	86,89	MMP-9	p38	4318	5594	Gene	Gene	up-regulates|amod|START_ENTITY /|nsubj|up-regulates /|nmod|pathways pathways|compound|END_ENTITY	Aldosterone up-regulates MMP-9 and MMP-9 / NGAL expression in human neutrophils through p38 , ERK1/2 and PI3K pathways .
25217631	0	MMP-9	64,69	rpS6	0,4	MMP-9	rpS6	4318	6194	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	rpS6 regulates blood-testis barrier dynamics via its effects on MMP-9 mediated by Akt signaling .
20087345	0	MMP-9	12,17	secreted_protein_acidic_and_rich_in_cysteine	51,95	MMP-9	secreted protein acidic and rich in cysteine	4318	6678	Gene	Gene	role|nmod|START_ENTITY role|nmod|effect effect|nmod|END_ENTITY	The role of MMP-9 in the anti-angiogenic effect of secreted_protein_acidic_and_rich_in_cysteine .
21428909	0	MMP-9	28,33	tumor_necrosis_factor-a	76,99	MMP-9	tumor necrosis factor-a	4318	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Double-stranded RNA induces MMP-9 gene expression in HaCaT keratinocytes by tumor_necrosis_factor-a .
11297541	0	MMP-9	116,121	tumor_necrosis_factor-alpha	38,65	MMP-9	tumor necrosis factor-alpha	4318	7124	Gene	Gene	activation|nmod|START_ENTITY mediated|dobj|activation mediated|nsubj|Transforming_growth_factor-beta Transforming_growth_factor-beta|dep|END_ENTITY	Transforming_growth_factor-beta - and tumor_necrosis_factor-alpha - mediated induction and proteolytic activation of MMP-9 in human skin .
9917505	0	MMP-9	30,35	tumor_necrosis_factor-alpha	101,128	MMP-9	tumor necrosis factor-alpha	4318	7124	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of MMP-9 expression in stromal cells of human giant_cell_tumor_of_bone by tumor_necrosis_factor-alpha .
16708801	0	MMP-9	57,62	vasoactive_intestinal_peptide	12,41	MMP-9	vasoactive intestinal peptide	81687(Tax:10116)	117064(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of vasoactive_intestinal_peptide on LPS-induced MMP-9 expression by alveolar macrophages in rats -RSB- .
20201953	0	MMP1	28,32	Akt	0,3	MMP1	Akt	4312	207	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts .
21440529	0	MMP1	62,66	EGFR	41,45	MMP1	EGFR	4312	1956	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	ERK/MAPK pathways play critical roles in EGFR ligands-induced MMP1 expression .
17106880	0	MMP1	94,98	JNK	50,53	MMP1	JNK	4312	5599	Gene	Gene	mRNA|compound|START_ENTITY upregulates|dobj|mRNA upregulates|nsubj|activation activation|appos|END_ENTITY	Oxidative stress-induced c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation in tendon cells upregulates MMP1 mRNA and protein expression .
18366705	0	MMP1	7,11	MMP8	69,73	MMP1	MMP8	4312	4317	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Plasma MMP1 and MMP8 expression in breast_cancer : protective role of MMP8 against lymph node metastasis .
12802622	0	MMP1	106,110	TIMP1	168,173	MMP1	TIMP1	4312	7076	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Effects of a vegetable extract from Lupinus albus -LRB- LU105 -RRB- on the production of matrix_metalloproteinases -LRB- MMP1 , MMP2 , MMP9 -RRB- and tissue_inhibitor_of_metalloproteinases -LRB- TIMP1 , TIMP2 -RRB- by human gingival fibroblasts in culture .
16596214	0	MMP1	63,67	TIMP1	108,113	MMP1	TIMP1	4312	7076	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	In situ gene expression and localization of metalloproteinases MMP1 , MMP2 , MMP3 , MMP9 , and their inhibitors TIMP1 and TIMP2 in human renal_cell_carcinoma .
24063540	0	MMP1	145,149	p65	105,108	MMP1	p65	4312	5970	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Astrocyte_elevated_gene-1 is associated with metastasis in head_and_neck_squamous_cell_carcinoma through p65 phosphorylation and upregulation of MMP1 .
15987457	0	MMP12	63,68	matrix_metalloproteinase_12	29,56	MMP12	matrix metalloproteinase 12	4321	4321	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms in the matrix_metalloproteinase_12 gene -LRB- MMP12 -RRB- and breast_cancer risk and survival : the Shanghai Breast_Cancer Study .
16459052	0	MMP13	59,64	IL-1beta	28,36	MMP13	IL-1beta	4322	3553	Gene	Gene	expression|nmod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	TAK1 downregulation reduces IL-1beta induced expression of MMP13 , MMP1 and TNF-alpha .
17971297	0	MMP13	30,35	Lef1	39,43	MMP13	Lef1	17386(Tax:10090)	16842(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of MMP13 by Lef1 in chondrocytes .
26201898	0	MMP13	88,93	Pituitary_tumor-transforming_gene_1	0,35	MMP13	Pituitary tumor-transforming gene 1	4322	9232	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Pituitary_tumor-transforming_gene_1 regulates invasion of prostate_cancer cells through MMP13 .
26201898	0	MMP13	88,93	Pituitary_tumor-transforming_gene_1	0,35	MMP13	Pituitary tumor-transforming gene 1	4322	9232	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Pituitary_tumor-transforming_gene_1 regulates invasion of prostate_cancer cells through MMP13 .
26369384	0	MMP13	16,21	SENP2	0,5	MMP13	SENP2	4322	59343	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SENP2 regulates MMP13 expression in a bladder_cancer cell line through SUMOylation of TBL1/TBLR1 .
26395178	0	MMP13	18,23	TGF-b	98,103	MMP13	TGF-b	4322	7040	Gene	Gene	Overexpression|nmod|START_ENTITY associated|nsubjpass|Overexpression associated|nmod|END_ENTITY	Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-b signalling pathway .
26650545	0	MMP13	54,59	TIPE2	0,5	MMP13	TIPE2	4322	79626	Gene	Gene	Mediates|nmod|START_ENTITY Mediates|nsubj|END_ENTITY	TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells .
22869368	0	MMP13	110,115	matrix_metalloproteinase_13	81,108	MMP13	matrix metalloproteinase 13	17386(Tax:10090)	17386(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Osterix regulates calcification and degradation of chondrogenic matrices through matrix_metalloproteinase_13 -LRB- MMP13 -RRB- expression in association with transcription factor Runx2 during endochondral ossification .
26850053	0	MMP14	68,73	KLF6	21,25	MMP14	KLF6	4323	1316	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular_injury .
26610210	0	MMP14	89,94	MicroRNA-22	0,11	MMP14	MicroRNA-22	4323	407004	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-22 inhibits tumor growth and metastasis in gastric_cancer by directly targeting MMP14 and Snail .
26284550	0	MMP14	0,5	VEGFR1	18,24	MMP14	VEGFR1	17387(Tax:10090)	14254(Tax:10090)	Gene	Gene	Cleavage|compound|START_ENTITY Cleavage|nmod|END_ENTITY	MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect .
26284550	0	MMP14	0,5	VEGFR1	18,24	MMP14	VEGFR1	17387(Tax:10090)	14254(Tax:10090)	Gene	Gene	Cleavage|compound|START_ENTITY Cleavage|nmod|END_ENTITY	MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect .
9609663	0	MMP15	73,78	membrane-type_2_matrix_metalloproteinase	26,66	MMP15	membrane-type 2 matrix metalloproteinase	4324	4324	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human membrane-type_2_matrix_metalloproteinase gene -LRB- MMP15 -RRB- to 16q12 .1 near DNA elements that are part of centromeric and non-centromeric heterochromatin of 11 human chromosomes .
12173047	0	MMP2	57,61	EMMPRIN	27,34	MMP2	EMMPRIN	4313	682	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Breast_cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A -LRB- 2 -RRB- and 5-lipoxygenase catalyzed pathway .
26938295	0	MMP2	93,97	MALAT1	49,55	MMP2	MALAT1	4313	378938	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling .
15449075	0	MMP2	38,42	MMP9	62,66	MMP2	MMP9	4313	4318	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Possible involvement of gelatinase A -LRB- MMP2 -RRB- and gelatinase B -LRB- MMP9 -RRB- in toxic_epidermal_necrolysis or Stevens-Johnson_syndrome .
20039633	0	MMP2	28,32	Matrix_metalloproteinase_2	0,26	MMP2	Matrix metalloproteinase 2	4313	4313	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Matrix_metalloproteinase_2 -LRB- MMP2 -RRB- inhibition : DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT .
24210072	0	MMP2	25,29	MicroRNA-29a	0,12	MMP2	MicroRNA-29a	4313	407021	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	MicroRNA-29a upregulates MMP2 in oral squamous_cell_carcinoma to promote cancer invasion and anti-apoptosis .
24168165	0	MMP2	102,106	NRD1	0,4	MMP2	NRD1	4313	4898	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression promotes|nmod|induction promotes|nsubj|END_ENTITY	NRD1 , which encodes nardilysin protein , promotes esophageal_cancer cell invasion through induction of MMP2 and MMP3 expression .
23902685	0	MMP2	32,36	Rab40b	0,6	MMP2	Rab40b	4313	10966	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast_cancer cells .
17498626	0	MMP2	21,25	SHIP-1	11,17	MMP2	SHIP-1	17390(Tax:10090)	16331(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells .
24347177	0	MMP2	64,68	TIMP1	57,62	MMP2	TIMP1	4313	7076	Gene	Gene	IL-6|appos|START_ENTITY IL-6|appos|END_ENTITY	The activation of TLR7 regulates the expression of VEGF , TIMP1 , MMP2 , IL-6 , and IL-15 in Hela cells .
26872030	0	MMP2	79,83	TIMP3	47,52	MMP2	TIMP3	81686(Tax:10116)	25358(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nmod|Regulation	The Angiogenic Effect of microRNA-21 Targeting TIMP3 through the Regulation of MMP2 and MMP9 .
24347177	0	MMP2	64,68	VEGF	51,55	MMP2	VEGF	4313	7422	Gene	Gene	IL-6|appos|START_ENTITY IL-6|compound|END_ENTITY	The activation of TLR7 regulates the expression of VEGF , TIMP1 , MMP2 , IL-6 , and IL-15 in Hela cells .
24192303	0	MMP2	46,50	matrix_metalloproteinase	20,44	MMP2	matrix metalloproteinase	4313	4313	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variants of matrix_metalloproteinase -LRB- MMP2 -RRB- gene influence metabolic_syndrome susceptibility .
11431697	0	MMP2	49,53	matrix_metalloproteinase_2	16,42	MMP2	matrix metalloproteinase 2	4313	4313	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation of the matrix_metalloproteinase_2 gene -LRB- MMP2 -RRB- causes a multicentric_osteolysis and arthritis_syndrome .
24637309	0	MMP2	57,61	matrix_metalloproteinase_2	29,55	MMP2	matrix metalloproteinase 2	4313	4313	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Patient with mutation in the matrix_metalloproteinase_2 -LRB- MMP2 -RRB- gene - a case report and review of the literature .
17223283	0	MMP20	68,73	matrix_metalloproteinase-20	39,66	MMP20	matrix metalloproteinase-20	64386	64386	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Identification and characterization of matrix_metalloproteinase-20 -LRB- MMP20 ; enamelysin -RRB- genes in reptile and amphibian .
22367194	0	MMP25	115,120	leukolysin	59,69	MMP25	leukolysin	64386	64386	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization and N-terminomics analysis of leukolysin , the membrane-type 6 matrix metalloprotease -LRB- MMP25 -RRB- : chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities .
14519668	0	MMP3	15,19	NOVH	0,4	MMP3	NOVH	4314	4856	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism .
23967200	0	MMP3	16,20	STAT3	0,5	MMP3	STAT3	4314	6774	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis .
22150225	0	MMP3	14,18	laminin_alpha_4	22,37	MMP3	laminin alpha 4	4314	3910	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MMP3 by laminin_alpha_4 in human osteoarthritic cartilage .
17065356	0	MMP3	55,59	matrix_metalloproteinase_3	27,53	MMP3	matrix metalloproteinase 3	4314	4314	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of matrix_metalloproteinase_3 -LRB- MMP3 -RRB- in preadipocytes/stromal vascular cells from nonobese nondiabetic versus obese nondiabetic Pima Indians .
22974215	0	MMP7	0,4	EpCAM	50,55	MMP7	EpCAM	4316	4072	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MMP7 is a target of the tumour-associated antigen EpCAM .
25234715	0	MMP7	17,21	MiR99a	0,6	MMP7	MiR99a	4316	407055	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	MiR99a modulates MMP7 and MMP13 to regulate invasiveness of Kaposi 's _ sarcoma .
24143235	0	MMP7	92,96	PTEN	102,106	MMP7	PTEN	4316	5728	Gene	Gene	START_ENTITY|nmod|manner manner|compound|END_ENTITY	Differential activation of Wnt-b-catenin pathway in triple negative breast_cancer increases MMP7 in a PTEN dependent manner .
24663337	0	MMP7	84,88	S100A8	89,95	MMP7	S100A8	4316	6279	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7 + S100A8 + in vitro and in vivo .
22645147	0	MMP7	114,118	matrix_metalloprotease_7	88,112	MMP7	matrix metalloprotease 7	4316	4316	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The forkhead box transcription factor FOXC1 promotes breast_cancer invasion by inducing matrix_metalloprotease_7 -LRB- MMP7 -RRB- expression .
21487925	0	MMP8	15,19	AKT3	21,25	MMP8	AKT3	4317	10000	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Uncommon GNAQ , MMP8 , AKT3 , EGFR , and PIK3R1 mutations in thyroid_cancers .
21487925	0	MMP8	15,19	GNAQ	9,13	MMP8	GNAQ	4317	2776	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Uncommon GNAQ , MMP8 , AKT3 , EGFR , and PIK3R1 mutations in thyroid_cancers .
18366705	0	MMP8	69,73	MMP1	7,11	MMP8	MMP1	4317	4312	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Plasma MMP1 and MMP8 expression in breast_cancer : protective role of MMP8 against lymph node metastasis .
19233360	0	MMP8	14,18	angiotensin_II	32,46	MMP8	angiotensin II	4317	183	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of MMP8 and MMP13 by angiotensin_II correlates to severe intra-plaque_hemorrhages and collagen breakdown in atherosclerotic_lesions with a vulnerable phenotype .
24705862	0	MMP9	36,40	Astrocyte_elevated_gene-1	0,25	MMP9	Astrocyte elevated gene-1	4318	92140	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Astrocyte_elevated_gene-1 activates MMP9 to increase invasiveness of colorectal_cancer .
23292863	0	MMP9	7,11	CD147	0,5	MMP9	CD147	4318	682	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	CD147 , MMP9 expression and clinical significance of basal-like breast_cancer .
21151179	0	MMP9	96,100	KLF8	0,4	MMP9	KLF8	4318	11279	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	KLF8 promotes human breast_cancer cell invasion and metastasis by transcriptional activation of MMP9 .
22065732	0	MMP9	116,120	Leptin	0,6	MMP9	Leptin	17395(Tax:10090)	16846(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Leptin promotes the mobilization of vascular progenitor cells and neovascularization by NOX2-mediated activation of MMP9 .
21143201	0	MMP9	0,4	MICA	14,18	MMP9	MICA	4318	100507436	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	MMP9 mediates MICA shedding in human osteosarcomas .
15449075	0	MMP9	62,66	MMP2	38,42	MMP9	MMP2	4318	4313	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Possible involvement of gelatinase A -LRB- MMP2 -RRB- and gelatinase B -LRB- MMP9 -RRB- in toxic_epidermal_necrolysis or Stevens-Johnson_syndrome .
18276934	0	MMP9	28,32	Matrix_metalloproteinase_9	0,26	MMP9	Matrix metalloproteinase 9	4318	4318	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Matrix_metalloproteinase_9 -LRB- MMP9 -RRB- expression in preeclamptic decidua and MMP9 induction by tumor_necrosis_factor_alpha and interleukin_1_beta in human first trimester decidual cells .
26864323	0	MMP9	43,47	NOTCH1	23,29	MMP9	NOTCH1	17395(Tax:10090)	18128(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic_Acid-free fatty_acid in colon_cancer cells .
23956041	0	MMP9	34,38	PTHrP	11,16	MMP9	PTHrP	4318	5744	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effects of PTHrP on expression of MMP9 and MMP13 in sika deer antler chondrocytes .
23526143	0	MMP9	38,42	Platelet-type_12-lipoxygenase	0,29	MMP9	Platelet-type 12-lipoxygenase	4318	239	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Platelet-type_12-lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/Akt/NF-kB .
25605249	0	MMP9	99,103	Protein_arginine_methyltransferase_7	0,36	MMP9	Protein arginine methyltransferase 7	4318	54496	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression promotes|nmod|induction promotes|nsubj|END_ENTITY	Protein_arginine_methyltransferase_7 promotes breast_cancer cell invasion through the induction of MMP9 expression .
25095981	0	MMP9	16,20	SEMA4b	0,6	MMP9	SEMA4b	4318	10509	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	SEMA4b inhibits MMP9 to prevent metastasis of non-small_cell_lung_cancer .
22821546	0	MMP9	125,129	Semaphorin_5A	0,13	MMP9	Semaphorin 5A	4318	9037	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Semaphorin_5A , an axon guidance molecule , enhances the invasion and metastasis of human gastric_cancer through activation of MMP9 .
12454321	0	MMP9	12,16	TIMP-1	49,55	MMP9	TIMP-1	4318	7076	Gene	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Circulating MMP9 , vitamin_D and variation in the TIMP-1 response with VDR genotype : mechanisms for inflammatory damage in chronic_disorders ?
23867621	0	MMP9	39,43	TRKB	31,35	MMP9	TRKB	4318	4915	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain .
21898400	0	MMP9	32,36	mTOR	61,65	MMP9	mTOR	4318	21977(Tax:10090)	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1 , and activate the Ras/Raf/MEK / Erk signaling pathway and NF-kB factor in human fibrosarcoma cells .
12830465	0	MMP9	83,87	matrix_metalloproteinase_9	55,81	MMP9	matrix metalloproteinase 9	4318	4318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of genetic variation and association in the matrix_metalloproteinase_9 -LRB- MMP9 -RRB- gene in ESRD patients .
25824442	0	MMP9	34,38	mir29b	66,72	MMP9	mir29b	4318	407024	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Cardiosome mediated regulation of MMP9 in diabetic heart : role of mir29b and mir455 in exercise .
15147870	0	MMP_2	63,68	MT1_MMP	31,38	MMP 2	MT1 MMP	4313	4323	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Cellular cholesterol regulates MT1_MMP dependent activation of MMP_2 via MEK-1 in HT1080 fibrosarcoma cells .
23394438	0	MN1	14,17	Meningioma_1	0,12	MN1	Meningioma 1	4330	4330	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Meningioma_1 -LRB- MN1 -RRB- expression : refined risk stratification in acute_myeloid_leukemia with normal cytogenetics -LRB- CN-AML -RRB- .
25549701	0	MN1	115,118	neurofibromatosis_type_2	66,90	MN1	neurofibromatosis type 2	4330	4771	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Exome sequencing on malignant_meningiomas identified mutations in neurofibromatosis_type_2 -LRB- NF2 -RRB- and meningioma_1 -LRB- MN1 -RRB- genes .
2259228	0	MNDA	66,70	myeloid_cell_nuclear_differentiation_antigen	20,64	MNDA	myeloid cell nuclear differentiation antigen	4332	4332	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human myeloid_cell_nuclear_differentiation_antigen -LRB- MNDA -RRB- in acute_leukemias .
24876927	0	MNS1	80,84	MFN2	29,33	MNS1	MFN2	17427(Tax:10090)	170731(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mitochondrial fusion protein MFN2 interacts with the mitostatin-related protein MNS1 required for mouse sperm flagellar structure and function .
8078587	0	MO15	51,55	cyclin	2,8	MO15	cyclin	1022	5111	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	A cyclin associated with the CDK-activating kinase MO15 .
23434407	0	MO25	38,42	MST4	17,21	MO25	MST4	51719	51765	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structure of the MST4 in complex with MO25 provides insights into its activation mechanism .
16674920	0	MOB1	56,60	LATS1	28,33	MOB1	LATS1	55233	9113	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The human tumour suppressor LATS1 is activated by human MOB1 at the membrane .
10866048	0	MODY1	134,139	HNF-4alpha	123,133	MODY1	HNF-4alpha	3172	3172	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Reduced pancreatic_polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha / MODY1 gene .
9294105	0	MODY1	102,107	hepatocyte_nuclear_factor-4alpha	69,101	MODY1	hepatocyte nuclear factor-4alpha	3172	3172	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Hepatic function in a family with a nonsense mutation -LRB- R154X -RRB- in the hepatocyte_nuclear_factor-4alpha / MODY1 gene .
9356021	0	MODY1	144,149	hepatocyte_nuclear_factor-4alpha	111,143	MODY1	hepatocyte nuclear factor-4alpha	3172	3172	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte_nuclear_factor-4alpha / MODY1 gene .
23139355	0	MODY2	104,109	glucokinase	86,97	MODY2	glucokinase	2645	2645	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene -LRB- MODY2 -RRB- .
11174836	0	MODY3	135,140	HNF-1alpha	108,118	MODY3	HNF-1alpha	6927	6927	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Counterregulatory responses to hypoglycemia in patients with maturity-onset diabetes_of_the_young caused by HNF-1alpha gene mutations -LRB- MODY3 -RRB- .
12488960	0	MODY3	78,83	HNF1_alpha	66,76	MODY3	HNF1 alpha	6927	6927	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a naturally occurring mutation -LRB- L107I -RRB- in the HNF1_alpha -LRB- MODY3 -RRB- gene .
20069546	0	MODY3	19,24	PSMD9	0,5	MODY3	PSMD9	6927	5715	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	PSMD9 is linked to MODY3 .
11270685	0	MODY4	44,49	IPF1	56,60	MODY4	IPF1	3651	3651	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional consequences of mutations in the MODY4 gene -LRB- IPF1 -RRB- and coexistence with MODY3 mutations .
15142986	0	MODY5	36,41	Hnf1beta	26,34	MODY5	Hnf1beta	6928	21410(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Selective deletion of the Hnf1beta -LRB- MODY5 -RRB- gene in beta-cells leads to altered gene expression and defective insulin release .
21617276	0	MODY_5	38,44	hepatocyte_nuclear_factor-1b	8,36	MODY 5	hepatocyte nuclear factor-1b	6928	6928	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A novel hepatocyte_nuclear_factor-1b -LRB- MODY_5 -RRB- gene mutation in a Romanian boy with pancreatic_calcifications , _ renal_and_hepatic_dysfunction .
15274043	0	MOG	37,40	Myelin_oligodendrocyte_glycoprotein	0,35	MOG	Myelin oligodendrocyte glycoprotein	4340	4340	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- gene is associated with obsessive-compulsive_disorder .
14561137	0	MOG	61,64	myelin_oligodendrocyte_glycoprotein	24,59	MOG	myelin oligodendrocyte glycoprotein	24558(Tax:10116)	24558(Tax:10116)	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Extracellular domain of myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- exhibits solvent-dependent conformational transitions .
15660663	0	MOG	58,61	myelin_oligodendrocyte_glycoprotein	21,56	MOG	myelin oligodendrocyte glycoprotein	4340	4340	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic study of the myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- gene in schizophrenia .
8522338	0	MOG	106,109	myelin_oligodendrocyte_glycoprotein	69,104	MOG	myelin oligodendrocyte glycoprotein	4340	4340	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphic tri - and tetranucleotide repeats in exons 1 and 8 of the myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- gene .
9192283	0	MOG	66,69	myelin_oligodendrocyte_glycoprotein	29,64	MOG	myelin oligodendrocyte glycoprotein	24558(Tax:10116)	24558(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The regional distribution of myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- in the developing rat CNS : an in vivo immunohistochemical study .
9394837	0	MOG	150,153	myelin_oligodendrocyte_glycoprotein	43,78	MOG	myelin oligodendrocyte glycoprotein	4340	4340	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Predominance of the autoimmune response to myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- in multiple_sclerosis : reactivity to the extracellular domain of MOG is directed against three main regions .
26292279	0	MOM-5	26,31	UNC-5	46,51	MOM-5	UNC-5	172856(Tax:6239)	177334(Tax:6239)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Receptor Receptor|compound|END_ENTITY	The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells .
26292279	0	MOM-5	26,31	UNC-5	46,51	MOM-5	UNC-5	172856(Tax:6239)	177334(Tax:6239)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Receptor Receptor|compound|END_ENTITY	The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells .
19369397	0	MONOPTEROS	60,70	DORNROSCHEN	0,11	MONOPTEROS	DORNROSCHEN	838573(Tax:3702)	837856(Tax:3702)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	DORNROSCHEN is a direct target of the auxin response factor MONOPTEROS in the Arabidopsis embryo .
18213645	0	MOR	55,58	mu-opioid_receptor	35,53	MOR	mu-opioid receptor	100033967(Tax:9796)	100033967(Tax:9796)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of the mu-opioid_receptor -LRB- MOR -RRB- in the equine cumulus-oocyte complex and its involvement in the seasonal regulation of oocyte meiotic competence .
10712637	0	MOR	47,50	mu_opioid_receptor	27,45	MOR	mu opioid receptor	18390(Tax:10090)	18390(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Specific activation of the mu_opioid_receptor -LRB- MOR -RRB- by endomorphin 1 and endomorphin 2 .
17130167	0	MOR	134,137	mu_opioid_receptor	114,132	MOR	mu opioid receptor	18390(Tax:10090)	18390(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence of the neuron-restrictive silencer factor -LRB- NRSF -RRB- interaction with Sp3 and its synergic repression to the mu_opioid_receptor -LRB- MOR -RRB- gene .
16122888	0	MOR-1	80,85	mu-opioid_receptor	60,78	MOR-1	mu-opioid receptor	4988	4988	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Characterization of the 3 ' untranslated region of the human mu-opioid_receptor -LRB- MOR-1 -RRB- mRNA .
7583338	0	MOR-1	34,39	mu_opioid_receptor	14,32	MOR-1	mu opioid receptor	25601(Tax:10116)	25601(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	CNS levels of mu_opioid_receptor -LRB- MOR-1 -RRB- mRNA during chronic treatment with morphine or naltrexone .
19144786	0	MOR1	78,82	mu-opioid_receptor	58,76	MOR1	mu-opioid receptor	4988	4988	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Long-term morphine treatment decreases the association of mu-opioid_receptor -LRB- MOR1 -RRB- mRNA with polysomes through miRNA23b .
12119101	0	MOR28	48,53	odorant_receptor	31,47	MOR28	odorant receptor	57269(Tax:10090)	258501(Tax:10090)	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Genomic analysis of the murine odorant_receptor MOR28 cluster : a possible role of gene conversion in maintaining the olfactory map .
26476214	0	MORC2	0,5	ArgBP2	20,26	MORC2	ArgBP2	22880	8470	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	MORC2 downregulates ArgBP2 via histone methylation in gastric_cancer cells .
26098774	0	MORC2	21,26	HDAC1	14,19	MORC2	HDAC1	22880	3065	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	By recruiting HDAC1 , MORC2 suppresses p21 Waf1/Cip1 in gastric_cancer .
12665628	0	MOST-1	16,22	C8orf17	24,31	MOST-1	C8orf17	100507249	100507249	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The novel human MOST-1 -LRB- C8orf17 -RRB- gene exhibits tissue specific expression , maps to chromosome 8q24 .2 , and is overexpressed/amplified in high grade cancers of the breast and prostate .
20215113	0	MOV10	27,32	Moloney_leukemia_virus_10	0,25	MOV10	Moloney leukemia virus 10	4343	4343	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Moloney_leukemia_virus_10 -LRB- MOV10 -RRB- protein inhibits retrovirus replication .
19254709	0	MOZ	24,27	Brpf1	0,5	MOZ	Brpf1	244349(Tax:10090)	78783(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex END_ENTITY|appos|subunit	Brpf1 , a subunit of the MOZ histone_acetyl_transferase complex , maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons .
15968979	0	MP19	124,128	LIM2	135,139	MP19	LIM2	3982	3982	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Identification of a lens-specific cis-acting element within the basal promoter of the human lens intrinsic membrane protein MP19 gene -LRB- LIM2 -RRB- .
11290961	0	MP19	53,57	Lim2	64,68	MP19	Lim2	233187(Tax:10090)	233187(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse lens fiber-cell intrinsic membrane protein MP19 gene -LRB- Lim2 -RRB- and granule membrane protein GMP-17 gene -LRB- Nkg7 -RRB- : Isolation and sequence analysis of two neighboring genes .
8654111	0	MP70	60,64	connexin49	27,37	MP70	connexin49	74140(Tax:10090)	100170231(Tax:9940)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of sheep connexin49 and its identity with MP70 .
9119380	0	MPB1	84,88	c-myc_promoter-binding_protein	52,82	MPB1	c-myc promoter-binding protein	2023	10260	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Chromosomal localization of the human gene encoding c-myc_promoter-binding_protein -LRB- MPB1 -RRB- to chromosome 1p35-pter .
26895100	0	MPC1	0,4	COUPTFII	55,63	MPC1	COUPTFII	51660	7026	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	MPC1 , a key gene in cancer metabolism , is regulated by COUPTFII in human prostate_cancer .
7541376	0	MPF	57,60	cdc2	44,48	MPF	cdc2	379785(Tax:8355)	379785(Tax:8355)	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Brefeldin_A provokes indirect activation of cdc2 kinase -LRB- MPF -RRB- in Xenopus oocytes , resulting in meiotic cell division .
10926775	0	MPF	42,45	cyclin_A1	11,20	MPF	cyclin A1	56047(Tax:10090)	12427(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	A role for cyclin_A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice .
1830371	0	MPF_and_cytostatic_factor	28,53	Mos	55,58	MPF and cytostatic factor	Mos	380246(Tax:8355)	397924(Tax:8355)	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Independent inactivation of MPF_and_cytostatic_factor -LRB- Mos -RRB- upon fertilization of Xenopus eggs .
10854423	0	MPG	33,36	3-Methyladenine-DNA_glycosylase	0,31	MPG	3-Methyladenine-DNA glycosylase	4350	4350	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	3-Methyladenine-DNA_glycosylase -LRB- MPG protein -RRB- interacts with human RAD23 proteins .
12014652	0	MPG	78,81	N-methylpurine-DNA_glycosylase	46,76	MPG	N-methylpurine-DNA glycosylase	4350	4350	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression of the DNA_repair_protein , N-methylpurine-DNA_glycosylase -LRB- MPG -RRB- in human gonads .
9328183	0	MPG	100,103	N-methylpurine-DNA_glycosylase	68,98	MPG	N-methylpurine-DNA glycosylase	4350	4350	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning and characterization of the promoter of the human N-methylpurine-DNA_glycosylase -LRB- MPG -RRB- gene .
9684856	0	MPG	78,81	N-methylpurine-DNA_glycosylase	46,76	MPG	N-methylpurine-DNA glycosylase	4350	4350	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression of the DNA_repair_protein , N-methylpurine-DNA_glycosylase -LRB- MPG -RRB- in breast_cancer .
26920759	0	MPH1	20,24	MTE1	0,4	MPH1	MTE1	7272	10965	Gene	Gene	Functions|nmod|START_ENTITY Functions|compound|END_ENTITY	MTE1 Functions with MPH1 in Double-Strand Break Repair .
25417716	0	MPK3	96,100	DRB1	27,31	MPK3	DRB1	823706(Tax:3702)	837498(Tax:3702)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MicroRNA biogenesis factor DRB1 is a phosphorylation target of mitogen activated protein kinase MPK3 in both rice and Arabidopsis .
25485581	0	MPK38	63,68	ASK1	107,111	MPK38	ASK1	17279(Tax:10090)	26408(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A crucial role for the phosphorylation of STRAP at Ser -LRB- 188 -RRB- by MPK38 in STRAP-dependent cell death through ASK1 , TGF-b , p53 , and PI3K/PDK1 signaling pathways .
25485581	0	MPK38	63,68	STRAP	42,47	MPK38	STRAP	17279(Tax:10090)	20901(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A crucial role for the phosphorylation of STRAP at Ser -LRB- 188 -RRB- by MPK38 in STRAP-dependent cell death through ASK1 , TGF-b , p53 , and PI3K/PDK1 signaling pathways .
17023433	0	MPK4	22,26	MEKK1	0,5	MPK4	MEKK1	828151(Tax:3702)	826409(Tax:3702)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis .
17142480	0	MPK4	36,40	MEKK1	0,5	MPK4	MEKK1	828151(Tax:3702)	826409(Tax:3702)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants .
22489043	0	MPL	59,62	CBL	28,31	MPL	CBL	4352	867	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	MPL	59,62	DNMT3A	33,39	MPL	DNMT3A	4352	1788	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	MPL	59,62	IDH1	41,45	MPL	IDH1	4352	3417	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	MPL	59,62	IDH2	47,51	MPL	IDH2	4352	3418	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
18479730	0	MPL	42,45	JAK2	130,134	MPL	JAK2	4352	3717	Gene	Gene	mutation|compound|START_ENTITY pattern|nmod|mutation similar|nsubj|pattern similar|nmod|that that|acl|seen seen|nmod|chronic_myeloproliferative_disorders chronic_myeloproliferative_disorders|nmod|V617F V617F|compound|END_ENTITY	Phospho-STAT5 expression pattern with the MPL W515L mutation is similar to that seen in chronic_myeloproliferative_disorders with JAK2 V617F .
21326037	0	MPL	0,3	JAK2	24,28	MPL	JAK2	4352	3717	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|patients patients|nummod|END_ENTITY	MPL mutation profile in JAK2 mutation-negative patients with myeloproliferative_disorders .
22489043	0	MPL	59,62	JAK2	53,57	MPL	JAK2	4352	3717	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22565617	0	MPL	23,26	JAK2	0,4	MPL	JAK2	4352	3717	Gene	Gene	myeloproliferative_neoplasms|compound|START_ENTITY haplotype|nmod|myeloproliferative_neoplasms haplotype|nsubj|GGCC GGCC|compound|END_ENTITY	JAK2 GGCC haplotype in MPL mutated myeloproliferative_neoplasms .
22596167	0	MPL	26,29	JAK2	0,4	MPL	JAK2	4352	3717	Gene	Gene	down-modulates|dobj|START_ENTITY down-modulates|nsubj|V617F V617F|compound|END_ENTITY	JAK2 V617F down-modulates MPL .
22489043	0	MPL	59,62	NF1	64,67	MPL	NF1	4352	4763	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	MPL	59,62	SF3B1	69,74	MPL	SF3B1	4352	23451	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
20113333	0	MPL	14,17	STAT3	134,139	MPL	STAT3	4352	6774	Gene	Gene	mutations|compound|START_ENTITY Screening|nmod|mutations Screening|dep|expression expression|nmod|END_ENTITY	Screening for MPL mutations in essential_thrombocythemia and primary myelofibrosis : normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets .
8751457	0	MPL	43,46	Thrombopoietin	0,14	MPL	Thrombopoietin	4352	7066	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Thrombopoietin : expression of its receptor MPL and proliferative effects on leukemic cells .
8020956	0	MPL	53,56	c-mpl	41,46	MPL	c-mpl	4352	4352	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and transcription of the human c-mpl gene -LRB- MPL -RRB- .
8948024	0	MPL	29,32	megakaryocyte_growth_and_development_factor	34,77	MPL	megakaryocyte growth and development factor	4352	7066	Gene	Gene	ligand|nmod|START_ENTITY ligand|appos|END_ENTITY	Recombinant human ligand for MPL , megakaryocyte_growth_and_development_factor -LRB- MGDF -RRB- , stimulates thrombopoiesis in vivo in normal and myelosuppressed baboons .
10736563	0	MPL	76,79	thrombopoietin	44,58	MPL	thrombopoietin	4352	7066	Gene	Gene	START_ENTITY|nsubj|Determination Determination|nmod|interactions interactions|nmod|END_ENTITY	Determination of interactions between human thrombopoietin and its receptor MPL by yeast two-hybrid system and affinity biosensor .
22389068	0	MPL	20,23	thrombopoietin	53,67	MPL	thrombopoietin	4352	7066	Gene	Gene	mutation|nmod|START_ENTITY results|nsubj|mutation results|nmod|sensitivity sensitivity|compound|END_ENTITY	A novel mutation in MPL -LRB- Y252H -RRB- results in increased thrombopoietin sensitivity in essential thrombocythemia .
8637239	0	MPL	27,30	thrombopoietin	71,85	MPL	thrombopoietin	4352	7066	Gene	Gene	START_ENTITY|dobj|effects effects|nmod|END_ENTITY	Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells .
8960108	0	MPL	57,60	thrombopoietin	14,28	MPL	thrombopoietin	4352	7066	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of thrombopoietin and thrombopoietin receptor MPL in human leukemia-lymphoma and solid tumor cell lines .
12460800	0	MPO	48,51	CYP2E1	40,46	MPO	CYP2E1	4353	1571	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association of genetic polymorphisms in CYP2E1 , MPO , NQO1 , GSTM1 , and GSTT1 genes with benzene_poisoning .
17424838	0	MPO	26,29	GSTP1	37,42	MPO	GSTP1	4353	2950	Gene	Gene	UGT1A6|compound|START_ENTITY UGT1A6|appos|END_ENTITY	-LSB- Genetic polymorphisms of MPO , NQO1 , GSTP1 , UGT1A6 associated with susceptibility of chronic benzene_poisoning -RSB- .
12460800	0	MPO	48,51	NQO1	53,57	MPO	NQO1	4353	1728	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association of genetic polymorphisms in CYP2E1 , MPO , NQO1 , GSTM1 , and GSTT1 genes with benzene_poisoning .
17424838	0	MPO	26,29	NQO1	31,35	MPO	NQO1	4353	1728	Gene	Gene	UGT1A6|compound|START_ENTITY UGT1A6|appos|END_ENTITY	-LSB- Genetic polymorphisms of MPO , NQO1 , GSTP1 , UGT1A6 associated with susceptibility of chronic benzene_poisoning -RSB- .
25698787	0	MPO	27,30	PF-1355	0,7	MPO	PF-1355	4353	1469230(Tax:186497)	Gene	Gene	Inhibitor|compound|START_ENTITY END_ENTITY|appos|Inhibitor	PF-1355 , a Mechanism-Based MPO Inhibitor , for the Prevention of Immune-Complex Vasculitis and Anti-GBM Glomerulonephritis .
12167444	0	MPO	38,41	myeloperoxidase	21,36	MPO	myeloperoxidase	100725291	100725291	Gene	Gene	Immunoreactivity|appos|START_ENTITY Immunoreactivity|nmod|END_ENTITY	Immunoreactivity for myeloperoxidase -LRB- MPO -RRB- in the vestibule after the injection of bacterial lipopolysaccharide into the middle ear .
15865234	0	MPO	88,91	myeloperoxidase	71,86	MPO	myeloperoxidase	4353	4353	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Cytofluorimetric assay for evaluation of CD16 receptor expression and myeloperoxidase -LRB- MPO -RRB- activity of neutrophils in patients with psoriasis_vulgaris treated with PUVA -RSB- .
1653580	0	MPO	44,47	myeloperoxidase	27,42	MPO	myeloperoxidase	4353	4353	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Cytofluorometric study of myeloperoxidase -LRB- MPO -RRB- expression in neutrophilic granulocytes of subjects with primary or secondary MPO_deficiency : analysis of the histographic antigen distribution using the Kolmogorov-Smirnov mathematical model -RSB- .
17613595	0	MPO	86,89	myeloperoxidase	69,84	MPO	myeloperoxidase	4353	4353	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An association study of two functional promotor polymorphisms in the myeloperoxidase -LRB- MPO -RRB- gene in multiple_sclerosis .
22427832	0	MPO	83,86	myeloperoxidase	66,81	MPO	myeloperoxidase	4353	4353	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Menopausal status modifies breast_cancer risk associated with the myeloperoxidase -LRB- MPO -RRB- G463A polymorphism in Caucasian women : a meta-analysis .
24222831	0	MPO	29,32	myeloperoxidase	12,27	MPO	myeloperoxidase	4353	4353	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of myeloperoxidase -LRB- MPO -RRB- for prognostic evaluation in sensitive cardiac_troponin_I negative chest_pain patients in the emergency_department .
2550177	0	MPO	46,49	myeloperoxidase	24,39	MPO	myeloperoxidase	4353	4353	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the human myeloperoxidase gene -LRB- MPO -RRB- to bands q21 .3 -- q23 of chromosome 17 .
26232301	0	MPO	68,71	myeloperoxidase	51,66	MPO	myeloperoxidase	4353	4353	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Smart imaging of acute_lung_injury : exploration of myeloperoxidase -LRB- MPO -RRB- activity using in vivo endoscopic confocal fluorescence microscopy -LRB- ECFM -RRB- .
26232301	0	MPO	68,71	myeloperoxidase	51,66	MPO	myeloperoxidase	4353	4353	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Smart imaging of acute_lung_injury : exploration of myeloperoxidase -LRB- MPO -RRB- activity using in vivo endoscopic confocal fluorescence microscopy -LRB- ECFM -RRB- .
8182931	0	MPO	75,78	myeloperoxidase	58,73	MPO	myeloperoxidase	17523(Tax:10090)	17523(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase -LRB- MPO -RRB- gene .
8683986	0	MPO	66,69	myeloperoxidase	49,64	MPO	myeloperoxidase	4353	4353	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cis-elements in the promoter region of the human myeloperoxidase -LRB- MPO -RRB- gene .
9783807	0	MPO	93,96	myeloperoxidase	76,91	MPO	myeloperoxidase	4353	4353	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of an upstream enhancer containing an AML1 site in the human myeloperoxidase -LRB- MPO -RRB- gene .
8824805	0	MPP1	63,67	p55	53,56	MPP1	p55	4354	4354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Complete genomic organization of the human erythroid p55 gene -LRB- MPP1 -RRB- , a membrane-associated guanylate kinase homologue .
19665017	0	MPP2	16,20	c-Src	36,41	MPP2	c-Src	50997(Tax:10090)	6714	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The PDZ protein MPP2 interacts with c-Src in epithelial cells .
13679854	0	MPP3	50,54	Dlg	105,108	MPP3	Dlg	4356	32083(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Association of a lung_tumor suppressor TSLC1 with MPP3 , a human homologue of Drosophila_tumor suppressor Dlg .
15914641	0	MPP4	14,18	MPP5	0,4	MPP4	MPP5	58538	64398	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	MPP5 recruits MPP4 to the CRB1 complex in photoreceptors .
15914641	0	MPP5	0,4	MPP4	14,18	MPP5	MPP4	64398	58538	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	MPP5 recruits MPP4 to the CRB1 complex in photoreceptors .
17237226	0	MPP7	28,32	LIN7	65,69	MPP7	LIN7	143098	8825	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions .
17332497	0	MPP7	18,22	hDlg1	53,58	MPP7	hDlg1	143098	1739	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation .
24108125	0	MPS1	21,25	RecQ-mediated_genome_instability_protein_2	64,106	MPS1	RecQ-mediated genome instability protein 2	7272	116028	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Monopolar_spindle_1 -LRB- MPS1 -RRB- protein-dependent phosphorylation of RecQ-mediated_genome_instability_protein_2 -LRB- RMI2 -RRB- at serine 112 is essential for BLM-Topo III a-RMI1-RMI2 -LRB- BTR -RRB- protein complex function upon spindle assembly checkpoint -LRB- SAC -RRB- activation during mitosis .
9848095	0	MPTP	57,61	Manganese_superoxide_dismutase	0,30	MPTP	Manganese superoxide dismutase	19255(Tax:10090)	20656(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|attenuates attenuates|amod|END_ENTITY	Manganese_superoxide_dismutase overexpression attenuates MPTP toxicity .
3265770	0	MPTP	18,22	glial_fibrillary_acidic_protein	80,111	MPTP	glial fibrillary acidic protein	19255(Tax:10090)	14580(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	The neurotoxicant MPTP -LRB- 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -RRB- increases glial_fibrillary_acidic_protein and decreases dopamine levels of the mouse striatum : evidence for glial response to injury .
21170271	0	MPYS	41,45	IFNb	59,63	MPYS	IFNb	340061	3456	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Cellular reactive oxygen species inhibit MPYS induction of IFNb .
10071056	0	MPZ	62,65	myelin_protein_zero	41,60	MPZ	myelin protein zero	4359	4359	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Thr124Met mutation in the peripheral myelin_protein_zero -LRB- MPZ -RRB- gene is associated with a clinically distinct Charcot-Marie-Tooth phenotype .
12845552	0	MPZ	84,87	myelin_protein_zero	63,82	MPZ	myelin protein zero	4359	4359	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Charcot-Marie-Tooth_disease : a novel Tyr145Ser mutation in the myelin_protein_zero -LRB- MPZ , P0 -RRB- gene causes different phenotypes in homozygous and heterozygous carriers within one family .
25720167	0	MPZ	95,98	myelin_protein_zero	74,93	MPZ	myelin protein zero	4359	4359	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A Costa Rican family affected with Charcot-Marie-Tooth_disease due to the myelin_protein_zero -LRB- MPZ -RRB- p.Thr124Met mutation shares the Belgian haplotype .
11439343	0	MPc3	21,25	AF9	41,44	MPc3	AF9	30951(Tax:10090)	70122(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The polycomb protein MPc3 interacts with AF9 , an MLL fusion partner in t -LRB- 9 ; 11 -RRB- -LRB- p22 ; q23 -RRB- acute_leukemias .
10721694	0	MPc3	60,64	Polycomb	45,53	MPc3	Polycomb	30951(Tax:10090)	12416(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and analysis of a third mouse Polycomb gene , MPc3 .
16632198	0	MR-1	37,41	Myofibrillogenesis_regulator_1	0,30	MR-1	Myofibrillogenesis regulator 1	25953	25953	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Myofibrillogenesis_regulator_1 gene -LRB- MR-1 -RRB- mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia .
26576642	0	MRAP	63,67	melanocortin_2_receptor_accessory_protein	20,61	MRAP	melanocortin 2 receptor accessory protein	56246	56246	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	H295R expression of melanocortin_2_receptor_accessory_protein -LRB- MRAP -RRB- results in ACTH responsiveness .
21139347	0	MRAP2	77,82	melanocortin_2_receptor_accessory_protein_2	32,75	MRAP2	melanocortin 2 receptor accessory protein 2	112609	112609	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	siRNA-mediated knockdown of the melanocortin_2_receptor_accessory_protein_2 -LRB- MRAP2 -RRB- gene confers resistance to methylmercury on HEK293 cells .
25162823	0	MRC2	0,4	TGFb1	32,37	MRC2	TGFb1	9902	7040	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	MRC2 expression correlates with TGFb1 and survival in hepatocellular_carcinoma .
21240187	0	MRCKb	38,43	ZO-1	33,37	MRCKb	ZO-1	9578	7082	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Cdc42-dependent formation of the ZO-1 / MRCKb complex at the leading edge controls cell migration .
7797078	0	MRF4	39,43	myogenin	72,80	MRF4	myogenin	17878(Tax:10090)	17928(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY results|nsubj|Inactivation results|nmod|up-regulation up-regulation|nmod|END_ENTITY	Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib_anomalies .
9186058	0	MRF4	0,4	myogenin	24,32	MRF4	myogenin	17878(Tax:10090)	17928(Tax:10090)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	MRF4 can substitute for myogenin during early stages of myogenesis .
14739931	0	MRF4	19,23	p38	50,53	MRF4	p38	4618	1432	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Phosphorylation of MRF4 transactivation domain by p38 mediates repression of specific myogenic genes .
20332121	0	MRG15	0,5	PALB2	24,29	MRG15	PALB2	10933	79728	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks .
18296658	0	MRG4	52,56	CaBP4	34,39	MRG4	CaBP4	22248(Tax:10090)	73660(Tax:10090)	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction and colocalization of CaBP4 and Unc119 -LRB- MRG4 -RRB- in photoreceptors .
10745140	0	MRI	20,23	CEA	70,73	MRI	CEA	78996	5670	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Ferumoxide-enhanced MRI in patients with colorectal_cancer and rising CEA : surgical correlation in early recurrence .
10457217	0	MRL/MP-lpr/lpr	113,127	p125FAK	90,97	MRL/MP-lpr/lpr	p125FAK	14102(Tax:10090)	14083(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Glomerular overexpression and increased tyrosine phosphorylation of focal adhesion kinase p125FAK in lupus-prone MRL/MP-lpr/lpr mice .
15017692	0	MRP	36,39	LRP	41,44	MRP	LRP	4363	9961	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	-LSB- Expression and implication of Pgp , MRP , LRP , GST-pi , Topo II alpha in tongue_squamous_cell_carcinoma -RSB- .
18972317	0	MRP	47,50	LRP	83,86	MRP	LRP	4363	9961	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma : further exploring the role of P53 and WT1 gene .
7671223	0	MRP	169,172	LRP	4,7	MRP	LRP	4363	4035	Gene	Gene	amplification|compound|START_ENTITY role|nmod|amplification plays|dobj|role evidence|dep|plays chromosome|dep|evidence MRP|nmod|chromosome proximal|xcomp|MRP proximal|nsubj|gene gene|compound|END_ENTITY	The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16 : evidence that chromosome breakage plays a key role in MRP or LRP gene amplification .
7671223	0	MRP	93,96	LRP	4,7	MRP	LRP	4363	4035	Gene	Gene	proximal|xcomp|START_ENTITY proximal|nsubj|gene gene|compound|END_ENTITY	The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16 : evidence that chromosome breakage plays a key role in MRP or LRP gene amplification .
10533474	0	MRP	41,44	Multidrug_resistance-associated_protein	0,39	MRP	Multidrug resistance-associated protein	8714	8714	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Multidrug_resistance-associated_protein -LRB- MRP -RRB- expression is correlated with expression of aberrant p53 protein in colorectal_cancer .
8712746	0	MRP	41,44	Multidrug_resistance-associated_protein	0,39	MRP	Multidrug resistance-associated protein	8714	8714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multidrug_resistance-associated_protein -LRB- MRP -RRB- gene expression in human lung_cancer .
9192801	0	MRP	30,33	Multidrug_resistance_protein	0,28	MRP	Multidrug resistance protein	4363	4363	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Multidrug_resistance_protein -LRB- MRP -RRB- expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein .
7591304	0	MRP	72,75	multidrug-resistance-associated_protein	31,70	MRP	multidrug-resistance-associated protein	8714	8714	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Preferential expression of the multidrug-resistance-associated_protein -LRB- MRP -RRB- in adenocarcinoma_of_the_lung .
7927879	0	MRP	65,68	multidrug-resistance-associated_protein	24,63	MRP	multidrug-resistance-associated protein	8714	8714	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of multidrug-resistance-associated_protein -LRB- MRP -RRB- gene expression in spontaneous drug resistance to vincristine , etoposide and adriamycin in human glioma cells .
9344662	0	MRP	89,92	multidrug-resistance_protein	54,82	MRP	multidrug-resistance protein	4363	4363	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the intron-exon organization of the human multidrug-resistance_protein gene -LRB- MRP -RRB- and alternative splicing of its mRNA .
10213370	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of multidrug_resistance-associated_protein -LRB- MRP -RRB- functional activity with pluronic block copolymers .
10330452	0	MRP	77,80	multidrug_resistance-associated_protein	36,75	MRP	multidrug resistance-associated protein	17250(Tax:10090)	17250(Tax:10090)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Tissue and cell distribution of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in mouse intestine and kidney .
10408915	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of multidrug_resistance-associated_protein -LRB- MRP -RRB- activity by rifampicin in human multidrug-resistant lung_tumor cells .
11206006	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in human gliomas .
7656221	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in thyroid_cancers .
7803281	0	MRP	64,67	multidrug_resistance-associated_protein	23,62	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in chronic_and_prolymphocytic_leukaemia .
7808005	0	MRP	59,62	multidrug_resistance-associated_protein	18,57	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in acute leukaemia .
7911548	0	MRP	59,62	multidrug_resistance-associated_protein	18,57	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in acute_and_chronic_leukemias .
7914828	0	MRP	72,75	multidrug_resistance-associated_protein	32,71	MRP	multidrug resistance-associated protein	24565(Tax:10116)	24565(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|detection detection|nmod|END_ENTITY	Immunochemical detection of the multidrug_resistance-associated_protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies .
7923112	0	MRP	59,62	multidrug_resistance-associated_protein	18,57	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma .
8050090	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in anaplastic_carcinoma of the thyroid .
8062263	0	MRP	53,56	multidrug_resistance-associated_protein	12,51	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of multidrug_resistance-associated_protein -LRB- MRP -RRB- messenger RNA in normal and malignant hematopoietic cells .
8275468	0	MRP	59,62	multidrug_resistance-associated_protein	18,57	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of multidrug_resistance-associated_protein -LRB- MRP -RRB- increases resistance to natural product drugs .
8558937	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- mRNA in blast cells from acute_myeloid_leukemia -LRB- AML -RRB- patients .
8605104	0	MRP	74,77	multidrug_resistance-associated_protein	33,72	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alterations in expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- gene in high-grade transitional_cell_carcinoma of the bladder .
8612802	0	MRP	69,72	multidrug_resistance-associated_protein	28,67	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Transport properties of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in human tumour cells .
8947528	0	MRP	59,62	multidrug_resistance-associated_protein	18,57	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in pancreatic_adenocarcinoma cell lines .
9096673	0	MRP	62,65	multidrug_resistance-associated_protein	21,60	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Possible role of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in chemoresistance of human melanoma cells .
9147606	0	MRP	53,56	multidrug_resistance-associated_protein	12,51	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The role of multidrug_resistance-associated_protein -LRB- MRP -RRB- expression in multidrug resistance .
9500978	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in brain microvessel endothelial cells .
9563653	0	MRP	55,58	multidrug_resistance-associated_protein	14,53	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in head_and_neck_squamous_cell_carcinoma .
9666517	0	MRP	80,83	multidrug_resistance-associated_protein	39,78	MRP	multidrug resistance-associated protein	8714	8714	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical significance of the increased multidrug_resistance-associated_protein -LRB- MRP -RRB- gene expression in patients with primary breast_cancer .
8534927	0	MRP	118,121	multidrug_resistance-related_protein	80,116	MRP	multidrug resistance-related protein	84798	84798	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Difloxacin reverses multidrug resistance in HL-60 / AR cells that overexpress the multidrug_resistance-related_protein -LRB- MRP -RRB- gene .
18003156	0	MRP	85,88	multidrug_resistance_associated_protein	44,83	MRP	multidrug resistance associated protein	8714	8714	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Poly -LRB- Ethylene_Glycol -RRB- hydrogels as possible multidrug_resistance_associated_protein -LRB- MRP -RRB- inhibitors .
8831715	0	MRP	67,70	multidrug_resistance_protein	37,65	MRP	multidrug resistance protein	4363	4363	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multidrug resistance mediated by the multidrug_resistance_protein -LRB- MRP -RRB- gene .
8926361	0	MRP	38,41	multidrug_resistance_protein	8,36	MRP	multidrug resistance protein	4363	4363	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of multidrug_resistance_protein -LRB- MRP -RRB- in glutathione_S-conjugate transport in mammalian cells .
9187270	0	MRP	123,126	multidrug_resistance_protein	93,121	MRP	multidrug resistance protein	4363	4363	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	ATP-dependent transport of aflatoxin_B1 and its glutathione conjugates by the product of the multidrug_resistance_protein -LRB- MRP -RRB- gene .
9393741	0	MRP	25,28	multidrug_resistance_protein	30,58	MRP	multidrug resistance protein	17250(Tax:10090)	17250(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Disruption of the murine MRP -LRB- multidrug_resistance_protein -RRB- gene leads to increased sensitivity to etoposide -LRB- VP-16 -RRB- and increased levels of glutathione .
9624242	0	MRP	48,51	multidrug_resistance_protein	18,46	MRP	multidrug resistance protein	4363	4363	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the multidrug_resistance_protein -LRB- MRP -RRB- in squamous_cell_carcinoma_of_the_oesophagus and response to pre-operative chemotherapy .
12564036	0	MRP	85,88	multidrug_resistant-associated_protein_gene	40,83	MRP	multidrug resistant-associated protein gene	4363	4363	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression and clinical implication of multidrug_resistant-associated_protein_gene -LRB- MRP -RRB- in patients with laryngeal_squamous_cell_carcinoma -RSB- .
9736046	0	MRP-1	28,33	CD9	34,37	MRP-1	CD9	928	928	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|expression expression|compound|END_ENTITY	Correlation of reduction in MRP-1 / CD9 and KAI1/CD82 expression with recurrences in breast_cancer patients .
10973813	0	MRP-14	35,41	S100A12	22,29	MRP-14	S100A12	6280	6283	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of human S100A12 with MRP-14 -LRB- S100A9 -RRB- .
12640137	0	MRP-14	25,31	S100A9	33,39	MRP-14	S100A9	20202(Tax:10090)	20202(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Myeloid cell function in MRP-14 -LRB- S100A9 -RRB- null mice .
11139250	0	MRP1	53,57	ABCC1	59,64	MRP1	ABCC1	4363	4363	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Identification of novel polymorphisms in the pM5 and MRP1 -LRB- ABCC1 -RRB- genes at locus 16p13 .1 and exclusion of both genes as responsible for pseudoxanthoma_elasticum .
21177244	0	MRP1	33,37	ABCC1	39,44	MRP1	ABCC1	4363	4363	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of human MRP1 -LRB- ABCC1 -RRB- is dependent on amino_acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2 .
16201286	0	MRP1	68,72	ACHN	76,80	MRP1	ACHN	4363	55323	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of trastuzumab in combination with IFN alpha-2b on HER2 and - MRP1 of ACHN .
11016657	0	MRP1	52,56	MRP2	58,62	MRP1	MRP2	4363	1244	Gene	Gene	MRP5|compound|START_ENTITY MRP5|appos|END_ENTITY	Specific detection of multidrug resistance proteins MRP1 , MRP2 , MRP3 , MRP5 , and MDR3 P-glycoprotein with a panel of monoclonal antibodies .
11164610	0	MRP1	73,77	MRP2	49,53	MRP1	MRP2	403453(Tax:9615)	403632(Tax:9615)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|gene gene|compound|END_ENTITY	Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1 .
12384350	0	MRP1	91,95	MRP2	154,158	MRP1	MRP2	4363	1244	Gene	Gene	multidrug_resistance-associated_protein|appos|START_ENTITY multidrug_resistance-associated_protein|appos|END_ENTITY	Direct evidence that saquinavir is transported by multidrug_resistance-associated_protein -LRB- MRP1 -RRB- and canalicular multispecific_organic_anion_transporter -LRB- MRP2 -RRB- .
14709322	0	MRP1	72,76	MRP2	78,82	MRP1	MRP2	396909(Tax:9823)	397535(Tax:9823)	Gene	Gene	P-glycoprotein|dep|START_ENTITY P-glycoprotein|dep|LRP LRP|compound|END_ENTITY	Induction of proteins involved in multidrug resistance -LRB- P-glycoprotein , MRP1 , MRP2 , LRP -RRB- and of CYP 3A4 by rifampicin in LLC-PK1 cells .
19844775	0	MRP1	63,67	MRP2	69,73	MRP1	MRP2	396909(Tax:9823)	397535(Tax:9823)	Gene	Gene	efflux|appos|START_ENTITY efflux|appos|END_ENTITY	Expression and distribution of CYP3A genes , CYP2B22 , and MDR1 , MRP1 , MRP2 , LRP efflux transporters in brain of control and rifampicin-treated pigs .
21511945	0	MRP1	112,116	MRP2	118,122	MRP1	MRP2	4363	1244	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1 , MRP2 , MRP3 , and MRP4 .
9270026	0	MRP1	126,130	MRP2	33,37	MRP1	MRP2	4363	1244	Gene	Gene	gene|appos|START_ENTITY homologues|nmod|gene Analysis|appos|homologues Analysis|nmod|expression expression|nmod|cMOAT cMOAT|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
11016657	0	MRP1	52,56	MRP3	64,68	MRP1	MRP3	4363	8714	Gene	Gene	MRP5|compound|START_ENTITY MRP5|appos|END_ENTITY	Specific detection of multidrug resistance proteins MRP1 , MRP2 , MRP3 , MRP5 , and MDR3 P-glycoprotein with a panel of monoclonal antibodies .
21511945	0	MRP1	112,116	MRP3	124,128	MRP1	MRP3	4363	8714	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1 , MRP2 , MRP3 , and MRP4 .
9270026	0	MRP1	126,130	MRP3	40,44	MRP1	MRP3	4363	8714	Gene	Gene	gene|appos|START_ENTITY homologues|nmod|gene Analysis|appos|homologues Analysis|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
15810950	0	MRP1	41,45	Multidrug_resistance-associated_protein	0,39	MRP1	Multidrug resistance-associated protein	4363	4363	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multidrug_resistance-associated_protein -LRB- MRP1 -RRB- gene is strongly expressed in gastric_carcinomas .
11697834	0	MRP1	76,80	P-glycoprotein	18,32	MRP1	P-glycoprotein	4363	5243	Gene	Gene	1|appos|START_ENTITY expression|dep|1 expression|nmod|proteins proteins|amod|END_ENTITY	The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 -LRB- MRP1 and MRP2 -RRB- in human malignant_mesothelioma .
11901101	0	MRP1	205,209	P-glycoprotein	142,156	MRP1	P-glycoprotein	403453(Tax:9615)	610926(Tax:9615)	Gene	Gene	protein|appos|START_ENTITY cells|appos|protein cells|acl|overexpressing overexpressing|dobj|Pgp Pgp|compound|END_ENTITY	Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney -LRB- MDCK -RRB- cells overexpressing P-glycoprotein -LRB- Pgp -RRB- , multidrug resistance-associated protein -LRB- MRP1 -RRB- , and canalicular multispecific organic anion transporter -LRB- cMOAT -RRB- .
11025451	0	MRP1	13,17	interleukin_1beta	75,92	MRP1	interleukin 1beta	4363	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of MRP1 and gamma-glutamylcysteine_synthetase gene expression by interleukin_1beta is mediated by nitric_oxide-related signalings in human colorectal_cancer cells .
19969624	0	MRP1	80,84	lung_resistance_protein	14,37	MRP1	lung resistance protein	4363	9961	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of lung_resistance_protein and multidrug_resistance-related_protein -LRB- MRP1 -RRB- in pediatric acute_lymphoblastic_leukemia .
10025956	0	MRP1	63,67	multidrug_resistance-associated_protein	22,61	MRP1	multidrug resistance-associated protein	8714	8714	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the multidrug_resistance-associated_protein -LRB- MRP1 -RRB- in human heavy metal-selected tumor cells .
11745741	0	MRP1	86,90	multidrug_resistance-associated_protein	45,84	MRP1	multidrug resistance-associated protein	8714	8714	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ritonavir induces P-glycoprotein expression , multidrug_resistance-associated_protein -LRB- MRP1 -RRB- expression , and drug transporter-mediated activity in a human intestinal cell line .
19306688	0	MRP1	66,70	multidrug_resistance-associated_protein	25,64	MRP1	multidrug resistance-associated protein	4363	4363	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Expression inhibition of multidrug_resistance-associated_protein -LRB- MRP1 -RRB- by multi-ribozyme expression system in HEK293 cells .
9270026	0	MRP1	126,130	multidrug_resistance-associated_protein	80,119	MRP1	multidrug resistance-associated protein	4363	8714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
10697508	0	MRP1	48,52	multidrug_resistance_protein	18,46	MRP1	multidrug resistance protein	4363	4363	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the multidrug_resistance_protein -LRB- MRP1 -RRB- in breast_cancer .
10791901	0	MRP1	88,92	multidrug_resistance_protein	51,79	MRP1	multidrug resistance protein	4363	4363	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Retroviral-mediated transfer and expression of the multidrug_resistance_protein 1 gene -LRB- MRP1 -RRB- protect human hematopoietic cells from antineoplastic drugs .
10828037	0	MRP1	45,49	multidrug_resistance_protein	16,44	MRP1	multidrug resistance protein	4363	4363	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Deletion of the multidrug_resistance_protein MRP1 gene in acute_myeloid_leukemia : the impact on MRP activity .
11467849	0	MRP1	133,137	multidrug_resistance_protein	103,131	MRP1	multidrug resistance protein	4363	4363	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of DNA-protein interactions in the 5 ' flanking and 5 ' untranslated regions of the human multidrug_resistance_protein -LRB- MRP1 -RRB- gene : evaluation of a putative antioxidant response element/AP -1 binding site .
20206183	0	MRP1	44,48	multidrug_resistance_protein-1	12,42	MRP1	multidrug resistance protein-1	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the multidrug_resistance_protein-1 -LRB- MRP1 -RRB- for endothelial progenitor cell function and survival .
11259786	0	MRP1	46,50	multidrug_resistance_protein_1	14,44	MRP1	multidrug resistance protein 1	24565(Tax:10116)	24565(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance_protein_1 -LRB- MRP1 -RRB- in the rat cochlea with special reference to the blood-inner ear barrier .
12391280	0	MRP1	50,54	multidrug_resistance_protein_1	18,48	MRP1	multidrug resistance protein 1	4363	4363	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the multidrug_resistance_protein_1 -LRB- MRP1 -RRB- by peptidomimetic glutathione-conjugate analogs .
10632726	0	MRP14	51,56	S100A9	43,49	MRP14	S100A9	20202(Tax:10090)	20202(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Biochemical characterization of the murine S100A9 -LRB- MRP14 -RRB- protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology .
9717674	0	MRP14	84,89	c-myb	26,31	MRP14	c-myb	6280	4602	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	The transcription factors c-myb and C/EBP _ alpha regulate the monocytic/myeloic gene MRP14 .
16863439	0	MRP2	30,34	ABCC2	36,41	MRP2	ABCC2	1244	1244	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Structure and function of the MRP2 -LRB- ABCC2 -RRB- protein and its role in drug disposition .
18926681	0	MRP2	17,21	ABCC2	23,28	MRP2	ABCC2	1244	1244	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms of MRP2 -LRB- ABCC2 -RRB- are associated with susceptibility to nonalcoholic_fatty_liver_disease .
23135210	0	MRP2	0,4	ABCC2	6,11	MRP2	ABCC2	1244	1244	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MRP2 -LRB- ABCC2 , cMOAT -RRB- expression in nuclear envelope of primary fallopian_tube_cancer cells is a new unfavorable prognostic factor .
26703673	0	MRP2	43,47	BCRP	60,64	MRP2	BCRP	1244	9429	Gene	Gene	ABCC2|appos|START_ENTITY ABCC2|appos|END_ENTITY	Genistein and Glyceollin Effects on ABCC2 -LRB- MRP2 -RRB- and ABCG2 -LRB- BCRP -RRB- in Caco-2 Cells .
11016657	0	MRP2	58,62	MRP1	52,56	MRP2	MRP1	1244	4363	Gene	Gene	MRP5|appos|START_ENTITY MRP5|compound|END_ENTITY	Specific detection of multidrug resistance proteins MRP1 , MRP2 , MRP3 , MRP5 , and MDR3 P-glycoprotein with a panel of monoclonal antibodies .
11164610	0	MRP2	49,53	MRP1	73,77	MRP2	MRP1	403632(Tax:9615)	403453(Tax:9615)	Gene	Gene	gene|compound|START_ENTITY distribution|nmod|gene distribution|nmod|END_ENTITY	Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1 .
12384350	0	MRP2	154,158	MRP1	91,95	MRP2	MRP1	1244	4363	Gene	Gene	multidrug_resistance-associated_protein|appos|START_ENTITY multidrug_resistance-associated_protein|appos|END_ENTITY	Direct evidence that saquinavir is transported by multidrug_resistance-associated_protein -LRB- MRP1 -RRB- and canalicular multispecific_organic_anion_transporter -LRB- MRP2 -RRB- .
14709322	0	MRP2	78,82	MRP1	72,76	MRP2	MRP1	397535(Tax:9823)	396909(Tax:9823)	Gene	Gene	LRP|compound|START_ENTITY P-glycoprotein|dep|LRP P-glycoprotein|dep|END_ENTITY	Induction of proteins involved in multidrug resistance -LRB- P-glycoprotein , MRP1 , MRP2 , LRP -RRB- and of CYP 3A4 by rifampicin in LLC-PK1 cells .
19844775	0	MRP2	69,73	MRP1	63,67	MRP2	MRP1	397535(Tax:9823)	396909(Tax:9823)	Gene	Gene	efflux|appos|START_ENTITY efflux|appos|END_ENTITY	Expression and distribution of CYP3A genes , CYP2B22 , and MDR1 , MRP1 , MRP2 , LRP efflux transporters in brain of control and rifampicin-treated pigs .
21511945	0	MRP2	118,122	MRP1	112,116	MRP2	MRP1	1244	4363	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1 , MRP2 , MRP3 , and MRP4 .
9270026	0	MRP2	33,37	MRP1	126,130	MRP2	MRP1	1244	4363	Gene	Gene	cMOAT|appos|START_ENTITY expression|nmod|cMOAT Analysis|nmod|expression Analysis|appos|homologues homologues|nmod|gene gene|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
11016657	0	MRP2	58,62	MRP3	64,68	MRP2	MRP3	1244	8714	Gene	Gene	MRP5|appos|START_ENTITY MRP5|appos|END_ENTITY	Specific detection of multidrug resistance proteins MRP1 , MRP2 , MRP3 , MRP5 , and MDR3 P-glycoprotein with a panel of monoclonal antibodies .
12631611	0	MRP2	107,111	MRP3	113,117	MRP2	MRP3	1244	8714	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
18250047	0	MRP2	55,59	MRP3	61,65	MRP2	MRP3	1244	8714	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	-LSB- Detection of multidrug resistance-associated proteins MRP2 , MRP3 , and MRP5 mRNA expressions in hepatocarcinoma cells using SYBR real-time PCR -RSB- .
21511945	0	MRP2	118,122	MRP3	124,128	MRP2	MRP3	1244	8714	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1 , MRP2 , MRP3 , and MRP4 .
26751618	0	MRP2	70,74	MRP3	76,80	MRP2	MRP3	1244	8714	Gene	Gene	UGT2B7|appos|START_ENTITY UGT2B7|appos|END_ENTITY	Oral Morphine Pharmacokinetic in Obesity : The Role of P-Glycoprotein , MRP2 , MRP3 , UGT2B7 , and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers .
9270026	0	MRP2	33,37	MRP3	40,44	MRP2	MRP3	1244	8714	Gene	Gene	cMOAT|appos|START_ENTITY expression|nmod|cMOAT Analysis|nmod|expression Analysis|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
12631611	0	MRP2	107,111	MRP4	119,123	MRP2	MRP4	1244	10257	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
9270026	0	MRP2	33,37	MRP4	46,50	MRP2	MRP4	1244	10257	Gene	Gene	cMOAT|appos|START_ENTITY expression|nmod|cMOAT Analysis|nmod|expression Analysis|appos|MRP3 MRP3|nummod|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
12631611	0	MRP2	107,111	MRP5	125,129	MRP2	MRP5	1244	10057	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
10464142	0	MRP2	70,74	multidrug-resistance_protein_2	38,68	MRP2	multidrug-resistance protein 2	1244	1244	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exon-intron organization of the human multidrug-resistance_protein_2 -LRB- MRP2 -RRB- gene mutated in Dubin-Johnson_syndrome .
19124075	0	MRP2	100,104	multidrug-resistance_protein_2	68,98	MRP2	multidrug-resistance protein 2	1244	1244	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Support vector machine and pharmacophore-based prediction models of multidrug-resistance_protein_2 -LRB- MRP2 -RRB- inhibitors .
11408547	0	MRP2	77,81	multidrug_resistance-associated_protein_2	34,75	MRP2	multidrug resistance-associated protein 2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Arsenic induces expression of the multidrug_resistance-associated_protein_2 -LRB- MRP2 -RRB- gene in primary rat and human hepatocytes .
12121239	0	MRP2	57,61	multidrug_resistance-associated_protein_2	14,55	MRP2	multidrug resistance-associated protein 2	1244	1244	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance-associated_protein_2 -LRB- MRP2 -RRB- in normal human tissues and carcinomas using tissue microarrays .
10691972	0	MRP2	88,92	multidrug_resistance_protein_2	56,86	MRP2	multidrug resistance protein 2	1244	1244	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the 5 ' - flanking region of the human multidrug_resistance_protein_2 -LRB- MRP2 -RRB- gene and its regulation in comparison withthe multidrug_resistance_protein_3 -LRB- MRP3 -RRB- gene .
11682439	0	MRP2	40,44	multidrug_resistance_protein_2	8,38	MRP2	multidrug resistance protein 2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of multidrug_resistance_protein_2 -LRB- MRP2 -RRB- in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells .
14569069	0	MRP2	40,44	multidrug_resistance_protein_2	8,38	MRP2	multidrug resistance protein 2	1244	1244	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of multidrug_resistance_protein_2 -LRB- MRP2 , ABCC2 -RRB- in alkylating agent detoxification : MRP2 potentiates glutathione_S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity .
15519272	0	MRP2	57,61	multidrug_resistance_protein_2	25,55	MRP2	multidrug resistance protein 2	1244	1244	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the multidrug_resistance_protein_2 -LRB- MRP2 -RRB- gene in a Japanese patient with Dubin-Johnson_syndrome .
21206495	0	MRP2	40,44	multidrug_resistance_protein_2	8,38	MRP2	multidrug resistance protein 2	1244	1244	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of multidrug_resistance_protein_2 -LRB- MRP2 -RRB- in chemoresistance and clinical outcome in oesophageal_squamous_cell_carcinoma .
23612356	0	MRP2	46,50	multidrug_resistance_protein_2	14,44	MRP2	multidrug resistance protein 2	1244	1244	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of multidrug_resistance_protein_2 -LRB- MRP2 , ABCC2 -RRB- expression by statins : involvement of SREBP-mediated gene regulation .
20600890	0	MRP2	125,129	p-glycoprotein	98,112	MRP2	p-glycoprotein	1244	5243	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 -LRB- p-glycoprotein -RRB- and ABCC2 -LRB- MRP2 -RRB- .
14570758	0	MRP3	20,24	ABCC3	13,18	MRP3	ABCC3	76408(Tax:10090)	76408(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of ABCC3 -LRB- MRP3 -RRB- by pregnane_X_receptor activators .
22585709	0	MRP3	47,51	ABCC3	40,45	MRP3	ABCC3	8714	8714	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Amplification and overexpression of the ABCC3 -LRB- MRP3 -RRB- gene in primary breast_cancer .
11016657	0	MRP3	64,68	MRP1	52,56	MRP3	MRP1	8714	4363	Gene	Gene	MRP5|appos|START_ENTITY MRP5|compound|END_ENTITY	Specific detection of multidrug resistance proteins MRP1 , MRP2 , MRP3 , MRP5 , and MDR3 P-glycoprotein with a panel of monoclonal antibodies .
21511945	0	MRP3	124,128	MRP1	112,116	MRP3	MRP1	8714	4363	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1 , MRP2 , MRP3 , and MRP4 .
9270026	0	MRP3	40,44	MRP1	126,130	MRP3	MRP1	8714	4363	Gene	Gene	Analysis|appos|START_ENTITY Analysis|appos|homologues homologues|nmod|gene gene|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
11016657	0	MRP3	64,68	MRP2	58,62	MRP3	MRP2	8714	1244	Gene	Gene	MRP5|appos|START_ENTITY MRP5|appos|END_ENTITY	Specific detection of multidrug resistance proteins MRP1 , MRP2 , MRP3 , MRP5 , and MDR3 P-glycoprotein with a panel of monoclonal antibodies .
12631611	0	MRP3	113,117	MRP2	107,111	MRP3	MRP2	8714	1244	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
18250047	0	MRP3	61,65	MRP2	55,59	MRP3	MRP2	8714	1244	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	-LSB- Detection of multidrug resistance-associated proteins MRP2 , MRP3 , and MRP5 mRNA expressions in hepatocarcinoma cells using SYBR real-time PCR -RSB- .
21511945	0	MRP3	124,128	MRP2	118,122	MRP3	MRP2	8714	1244	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Cannabinoid type 1 receptor antagonists modulate transport activity of multidrug resistance-associated proteins MRP1 , MRP2 , MRP3 , and MRP4 .
26751618	0	MRP3	76,80	MRP2	70,74	MRP3	MRP2	8714	1244	Gene	Gene	UGT2B7|appos|START_ENTITY UGT2B7|appos|END_ENTITY	Oral Morphine Pharmacokinetic in Obesity : The Role of P-Glycoprotein , MRP2 , MRP3 , UGT2B7 , and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers .
9270026	0	MRP3	40,44	MRP2	33,37	MRP3	MRP2	8714	1244	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|expression expression|nmod|cMOAT cMOAT|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
12631611	0	MRP3	113,117	MRP4	119,123	MRP3	MRP4	8714	10257	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
12631611	0	MRP3	113,117	MRP5	125,129	MRP3	MRP5	8714	10057	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
10691972	0	MRP3	172,176	multidrug_resistance_protein_3	140,170	MRP3	multidrug resistance protein 3	5244	5244	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Characterization of the 5 ' - flanking region of the human multidrug_resistance_protein_2 -LRB- MRP2 -RRB- gene and its regulation in comparison withthe multidrug_resistance_protein_3 -LRB- MRP3 -RRB- gene .
17344354	0	MRP4	15,19	ABCC4	21,26	MRP4	ABCC4	239273(Tax:10090)	239273(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of MRP4 -LRB- ABCC4 -RRB- in the luminal efflux of ceftizoxime and cefazolin in the kidney .
12631611	0	MRP4	119,123	MRP2	107,111	MRP4	MRP2	10257	1244	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
9270026	0	MRP4	46,50	MRP2	33,37	MRP4	MRP2	10257	1244	Gene	Gene	MRP3|nummod|START_ENTITY Analysis|appos|MRP3 Analysis|nmod|expression expression|nmod|cMOAT cMOAT|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
12631611	0	MRP4	119,123	MRP3	113,117	MRP4	MRP3	10257	8714	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
12631611	0	MRP4	119,123	MRP5	125,129	MRP4	MRP5	10257	10057	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
23503867	0	MRP4	32,36	Multidrug_resistance_protein_4	0,30	MRP4	Multidrug resistance protein 4	10257	10257	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Multidrug_resistance_protein_4 -LRB- MRP4 -RRB- expression in prostate_cancer is associated with androgen signaling and decreases with tumor progression .
18625884	0	MRP4	43,47	multidrug_resistance_protein_4	11,41	MRP4	multidrug resistance protein 4	10257	10257	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for multidrug_resistance_protein_4 -LRB- MRP4 ; ABCC4 -RRB- in human dendritic cell migration .
12631611	0	MRP5	125,129	MRP2	107,111	MRP5	MRP2	10057	1244	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
12631611	0	MRP5	125,129	MRP3	113,117	MRP5	MRP3	10057	8714	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
12631611	0	MRP5	125,129	MRP4	119,123	MRP5	MRP4	10057	10257	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2 , MRP3 , MRP4 , MRP5 , and SMRP in childhood acute_myeloid_leukemia .
19323627	0	MRP5	57,61	multidrug_resistance_associated_protein_5	14,55	MRP5	multidrug resistance associated protein 5	10057	10057	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of multidrug_resistance_associated_protein_5 -LRB- MRP5 -RRB- on cornea and its role in drug efflux .
15645653	0	MRP6	85,89	ABCC6	78,83	MRP6	ABCC6	368	368	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of two novel missense mutations -LRB- p.R1221C and p.R1357W -RRB- in the ABCC6 -LRB- MRP6 -RRB- gene in a Japanese patient with pseudoxanthoma_elasticum -LRB- PXE -RRB- .
15889270	0	MRP6	19,23	ABCC6	12,17	MRP6	ABCC6	368	368	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of ABCC6 -LRB- MRP6 -RRB- in normal human tissues .
10464253	0	MRP8	77,81	S100A12	0,7	MRP8	S100A12	6279	6283	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14 .
10486246	0	MRP8	79,83	cell_surface_antigen	24,44	MRP8	cell surface antigen	6279	963	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a B cell_surface_antigen with homology to the S100 protein MRP8 .
7542868	0	MRP8	144,148	migration_inhibitory_factor-related_protein_8	97,142	MRP8	migration inhibitory factor-related protein 8	6279	6279	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration_inhibitory_factor-related_protein_8 -LRB- MRP8 -RRB- and MRP14 to keratin intermediate filaments .
20079882	0	MRPS29	51,57	mitochondrial_ribosomal_protein_S29	14,49	MRPS29	mitochondrial ribosomal protein S29	7818	7818	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of mitochondrial_ribosomal_protein_S29 -LRB- MRPS29 -RRB- expression by a 5 ' - upstream open reading frame .
26427135	0	MRT5	77,81	NSUN2	70,75	MRT5	NSUN2	54888	54888	Gene	Gene	Genes|appos|START_ENTITY Genes|compound|END_ENTITY	Frequencies of Six -LRB- Five Novel -RRB- STR Markers Linked to TUSC3 -LRB- MRT7 -RRB- or NSUN2 -LRB- MRT5 -RRB- Genes Used for Homozygosity Mapping of Recessive Intellectual_Disability .
25955164	0	MRTF-A	52,58	Myocardin_Related_Transcription_Factor-A	10,50	MRTF-A	Myocardin Related Transcription Factor-A	223701(Tax:10090)	223701(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	A Role of Myocardin_Related_Transcription_Factor-A -LRB- MRTF-A -RRB- in Scleroderma Related Fibrosis .
25446178	0	MRTF-A	12,18	angiotensin_II	28,42	MRTF-A	angiotensin II	223701(Tax:10090)	11606(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Endothelial MRTF-A mediates angiotensin_II induced cardiac_hypertrophy .
25955685	0	MRTF-A	57,63	miR-206	0,7	MRTF-A	miR-206	57591	406989	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	miR-206 inhibits metastasis-relevant traits by degrading MRTF-A in anaplastic_thyroid_cancer .
26494001	0	MRTO4	42,47	Mrt4	28,32	MRTO4	Mrt4	51154	100009675	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Molecular behavior of human Mrt4 protein , MRTO4 , in stress conditions is regulated by its C-terminal region .
17006958	0	MS-KIF18A	0,9	estrogen_receptor	41,58	MS-KIF18A	estrogen receptor	81930	2099	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	MS-KIF18A , a kinesin , is associated with estrogen_receptor .
23354597	0	MS110	33,38	BRCA1	58,63	MS110	BRCA1	3207690(Tax:155537)	672	Gene	Gene	Validation|nmod|START_ENTITY Validation|nmod|END_ENTITY	Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast_and_ovarian_tumours .
7934914	0	MS2	59,62	coat-protein	32,44	MS2	coat-protein	100271694	64083	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Translational initiation at the coat-protein gene of phage MS2 : native upstream RNA relieves inhibition by local secondary structure .
19818099	0	MS4A3	44,49	HTm4	38,42	MS4A3	HTm4	170813(Tax:10090)	170813(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Characterization of the expression of HTm4 -LRB- MS4A3 -RRB- , a cell cycle regulator , in human peripheral blood cells and normal and malignant tissues .
21072172	0	MS4a4B	0,6	CD20	10,14	MS4a4B	CD20	60361(Tax:10090)	12482(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	MS4a4B , a CD20 homologue in T cells , inhibits T cell propagation by modulation of cell cycle .
15215198	0	MSAP	0,4	meichroacidin	10,23	MSAP	meichroacidin	66902(Tax:10090)	22092(Tax:10090)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	MSAP , the meichroacidin homolog of carp -LRB- Cyprinus_carpio -RRB- , differs from the rodent counterpart in germline expression and involves flagellar differentiation .
21715650	0	MSBP1	12,17	HY5	34,37	MSBP1	HY5	835300(Tax:3702)	830996(Tax:3702)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Arabidopsis MSBP1 is activated by HY5 and HYH and is involved in photomorphogenesis and brassinosteroid sensitivity regulation .
10673329	0	MSF	105,108	MLL_septin-like_fusion	76,98	MSF	MLL septin-like fusion	10216	10216	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic and expression analyses of alternatively spliced transcripts of the MLL_septin-like_fusion gene -LRB- MSF -RRB- that map to a 17q25 region of loss in breast_and_ovarian_tumors .
6999821	0	MSF	22,25	macrophage_slowing_factor	27,52	MSF	macrophage slowing factor	10216	10216	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of the MSF -LRB- macrophage_slowing_factor -RRB- release by phytohemagglutinin using the macrophage electrophoretic mobility test -LRB- MEM test -RRB- .
6143618	0	MSH	63,66	LPH	68,71	MSH	LPH	5443	3938	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Differentiation of cells producing polypeptide hormones -LRB- ACTH , MSH , LPH , alpha - _ and_beta-endorphin , GH and PRL -RRB- in the fetal porcine anterior pituitary .
3607524	0	MSH	49,52	melanocyte_stimulating_hormone	17,47	MSH	melanocyte stimulating hormone	5443	5443	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of melanocyte_stimulating_hormone -LRB- MSH -RRB- within specific brain regions in aged squirrel monkeys .
21528083	0	MSH2	15,19	E-cadherin	21,31	MSH2	E-cadherin	4436	999	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
20708344	0	MSH2	82,86	GSTM1	68,73	MSH2	GSTM1	4436	2944	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	MSH2	82,86	GSTT1	75,80	MSH2	GSTT1	4436	2952	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
10612836	0	MSH2	11,15	MLH1	18,22	MSH2	MLH1	4436	4292	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Four novel MSH2 / MLH1 gene mutations in portuguese HNPCC families .
11600610	0	MSH2	0,4	MLH1	57,61	MSH2	MLH1	4436	4292	Gene	Gene	carriers|compound|START_ENTITY risk|nsubj|carriers risk|nmod|carriers carriers|compound|END_ENTITY	MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers : a study of hereditary nonpolyposis colorectal_cancer families .
11830542	0	MSH2	0,4	MLH1	20,24	MSH2	MLH1	4436	4292	Gene	Gene	START_ENTITY|nmod|contrast contrast|nmod|END_ENTITY	MSH2 in contrast to MLH1 and MSH6 is frequently inactivated by exonic and promoter rearrangements in hereditary_nonpolyposis_colorectal_cancer .
15942939	0	MSH2	93,97	MLH1	99,103	MSH2	MLH1	4436	4292	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2 , MLH1 , MSH6 , and PMS2 responsible for hereditary nonpolyposis colorectal_cancer -LRB- HNPCC -RRB- .
16237223	0	MSH2	125,129	MLH1	119,123	MSH2	MLH1	4436	4292	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Assay validation for identification of hereditary_nonpolyposis_colon cancer-causing mutations in mismatch repair genes MLH1 , MSH2 , and MSH6 .
16540742	0	MSH2	79,83	MLH1	73,77	MSH2	MLH1	4436	4292	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Optimization of antibodies for detection of the mismatch repair proteins MLH1 , MSH2 , MSH6 , and PMS2 using a biotin-free visualization system .
17724798	0	MSH2	53,57	MLH1	29,33	MSH2	MLH1	4436	4292	Gene	Gene	expression|nummod|START_ENTITY homologue|dobj|expression homologue|nsubj|END_ENTITY	Importance of MutL homologue MLH1 and MutS homologue MSH2 expression in Turkish patients with sporadic colorectal_cancer .
18787700	0	MSH2	120,124	MLH1	6,10	MSH2	MLH1	4436	4292	Gene	Gene	functions|nummod|START_ENTITY repair|nsubj|functions signaling|advcl|repair checkpoint|acl|signaling participates|nmod|checkpoint participates|nsubj|protein protein|compound|END_ENTITY	Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks , while MSH2 functions in DNA repair .
20708344	0	MSH2	82,86	MLH1	88,92	MSH2	MLH1	4436	4292	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
21242524	0	MSH2	25,29	MLH1	31,35	MSH2	MLH1	17685(Tax:10090)	17350(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Mismatch repair proteins MSH2 , MLH1 , and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining .
22669205	0	MSH2	28,32	MLH1	22,26	MSH2	MLH1	4436	4292	Gene	Gene	KRAS|dep|START_ENTITY KRAS|compound|END_ENTITY	Missense mutations in MLH1 , MSH2 , KRAS , and APC genes in colorectal_cancer patients in Malaysia .
22892529	0	MSH2	54,58	MLH1	48,52	MSH2	MLH1	4436	4292	Gene	Gene	MSH6|compound|START_ENTITY END_ENTITY|dep|MSH6	Clinical utility gene card for : Lynch_syndrome -LRB- MLH1 , MSH2 , MSH6 , PMS2 , EPCAM -RRB- - update 2012 .
24122742	0	MSH2	67,71	MLH1	104,108	MSH2	MLH1	4436	4292	Gene	Gene	cancers|nmod|START_ENTITY Excess|nmod|cancers germline|nsubj|Excess germline|nmod|END_ENTITY	Excess of extracolonic non-endometrial multiple primary cancers in MSH2 germline mutation carriers over MLH1 .
24924810	0	MSH2	75,79	MLH1	69,73	MSH2	MLH1	4436	4292	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Assessing how reduced expression levels of the mismatch repair genes MLH1 , MSH2 , and MSH6 affect repair efficiency .
24995467	0	MSH2	49,53	MLH1	43,47	MSH2	MLH1	4436	4292	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of DNA mismatch repair proteins MLH1 , MSH2 , and MSH6 in recurrent glioblastoma .
8993979	0	MSH2	44,48	MLH1	13,17	MSH2	MLH1	4436	4292	Gene	Gene	frequent|nmod|START_ENTITY frequent|nsubj|Mutations Mutations|nmod|END_ENTITY	Mutations in MLH1 are more frequent than in MSH2 in sporadic colorectal_cancers with microsatellite_instability .
15942939	0	MSH2	93,97	MSH6	105,109	MSH2	MSH6	4436	2956	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2 , MLH1 , MSH6 , and PMS2 responsible for hereditary nonpolyposis colorectal_cancer -LRB- HNPCC -RRB- .
16540742	0	MSH2	79,83	MSH6	85,89	MSH2	MSH6	4436	2956	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Optimization of antibodies for detection of the mismatch repair proteins MLH1 , MSH2 , MSH6 , and PMS2 using a biotin-free visualization system .
22277660	0	MSH2	66,70	MSH6	78,82	MSH2	MSH6	4436	2956	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Biochemical analysis of the human mismatch repair proteins hMutSa MSH2 -LRB- G674A -RRB- - MSH6 and MSH2-MSH6 -LRB- T1219D -RRB- .
22581703	0	MSH2	38,42	MSH6	50,54	MSH2	MSH6	4436	2956	Gene	Gene	pairs|compound|START_ENTITY pairs|compound|END_ENTITY	Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients .
24919261	0	MSH2	36,40	MSH6	54,58	MSH2	MSH6	4436	2956	Gene	Gene	MLH1|compound|START_ENTITY examination|nmod|MLH1 END_ENTITY|nsubj|examination	-LSB- Immunohistochemical examination of MSH2 , PMS2 , MLH1 , MSH6 compared with the analysis of microsatellite instability in colon_adenocarcinoma -RSB- .
25761822	0	MSH2	16,20	MSH6	22,26	MSH2	MSH6	4436	2956	Gene	Gene	MLH1|nummod|START_ENTITY MLH1|nummod|END_ENTITY	Origin of MLH1 , MSH2 , MSH6 , and PMS2 mutations can help inform long term care strategies for patients with colorectal_and_endometrial_cancer .
8723353	0	MSH2	88,92	MSH6	0,4	MSH2	MSH6	854063(Tax:4932)	851671(Tax:4932)	Gene	Gene	heterodimer|nmod|START_ENTITY mismatches|nmod|heterodimer binds|xcomp|mismatches protein|acl:relcl|binds END_ENTITY|appos|protein	MSH6 , a Saccharomyces_cerevisiae protein that binds to mismatches as a heterodimer with MSH2 .
18635600	0	MSH2	24,28	MutS_homolog_2	8,22	MSH2	MutS homolog 2	4436	4436	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of MutS_homolog_2 -LRB- MSH2 -RRB- in intestinal myofibroblast proliferation during Crohn 's _ disease stricture formation .
23143036	0	MSH2	125,129	MutS_homolog_2	109,123	MSH2	MutS homolog 2	406845(Tax:7955)	406845(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cadmium -LRB- Cd -RRB- - induced oxidative stress down-regulates the gene expression of DNA mismatch recognition proteins MutS_homolog_2 -LRB- MSH2 -RRB- and MSH6 in zebrafish -LRB- Danio_rerio -RRB- embryos .
21528083	0	MSH2	15,19	Shp2	9,13	MSH2	Shp2	4436	5781	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
20708344	0	MSH2	82,86	XPD	63,66	MSH2	XPD	4436	2068	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	MSH2	82,86	XRCC3	56,61	MSH2	XRCC3	4436	7517	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
19015635	0	MSH2	45,49	hTERT	18,23	MSH2	hTERT	4436	7015	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of the hTERT promoter activity by MSH2 , the hnRNPs_K_and_D , and GRHL2 in human oral_squamous_cell_carcinoma cells .
21528083	0	MSH2	15,19	p53	33,36	MSH2	p53	4436	7157	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
21075794	0	MSH6	24,28	Ku70	48,52	MSH6	Ku70	2956	2547	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Mismatch-repair protein MSH6 is associated with Ku70 and regulates DNA double-strand break repair .
12610360	0	MSH6	80,84	MLH1	68,72	MSH6	MLH1	2956	4292	Gene	Gene	MSH2|nummod|START_ENTITY END_ENTITY|appos|MSH2	The immunohistochemical detection of mismatch repair gene proteins -LRB- MLH1 , MSH2 , MSH6 , and PMS2 -RRB- : practical aspects in antigen retrieval and biotin blocking protocols .
15483016	0	MSH6	99,103	MLH1	151,155	MSH6	MLH1	2956	4292	Gene	Gene	families|nmod|START_ENTITY onset|nmod|families age|nmod|onset incidence|nmod|age germline|nsubj|incidence germline|advcl|families families|nmod|mutations mutations|nummod|END_ENTITY	Lower incidence of colorectal_cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations : the German Hereditary_Nonpolyposis_Colorectal_Cancer_Consortium .
15942939	0	MSH6	105,109	MLH1	99,103	MSH6	MLH1	2956	4292	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2 , MLH1 , MSH6 , and PMS2 responsible for hereditary nonpolyposis colorectal_cancer -LRB- HNPCC -RRB- .
16540742	0	MSH6	85,89	MLH1	73,77	MSH6	MLH1	2956	4292	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Optimization of antibodies for detection of the mismatch repair proteins MLH1 , MSH2 , MSH6 , and PMS2 using a biotin-free visualization system .
24919261	0	MSH6	54,58	MLH1	48,52	MSH6	MLH1	2956	4292	Gene	Gene	START_ENTITY|nsubj|examination examination|nmod|END_ENTITY	-LSB- Immunohistochemical examination of MSH2 , PMS2 , MLH1 , MSH6 compared with the analysis of microsatellite instability in colon_adenocarcinoma -RSB- .
15942939	0	MSH6	105,109	MSH2	93,97	MSH6	MSH2	2956	4436	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2 , MLH1 , MSH6 , and PMS2 responsible for hereditary nonpolyposis colorectal_cancer -LRB- HNPCC -RRB- .
16540742	0	MSH6	85,89	MSH2	79,83	MSH6	MSH2	2956	4436	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Optimization of antibodies for detection of the mismatch repair proteins MLH1 , MSH2 , MSH6 , and PMS2 using a biotin-free visualization system .
22277660	0	MSH6	78,82	MSH2	66,70	MSH6	MSH2	2956	4436	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Biochemical analysis of the human mismatch repair proteins hMutSa MSH2 -LRB- G674A -RRB- - MSH6 and MSH2-MSH6 -LRB- T1219D -RRB- .
22581703	0	MSH6	50,54	MSH2	38,42	MSH6	MSH2	2956	4436	Gene	Gene	pairs|compound|START_ENTITY pairs|compound|END_ENTITY	Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients .
24919261	0	MSH6	54,58	MSH2	36,40	MSH6	MSH2	2956	4436	Gene	Gene	START_ENTITY|nsubj|examination examination|nmod|MLH1 MLH1|compound|END_ENTITY	-LSB- Immunohistochemical examination of MSH2 , PMS2 , MLH1 , MSH6 compared with the analysis of microsatellite instability in colon_adenocarcinoma -RSB- .
25761822	0	MSH6	22,26	MSH2	16,20	MSH6	MSH2	2956	4436	Gene	Gene	MLH1|nummod|START_ENTITY MLH1|nummod|END_ENTITY	Origin of MLH1 , MSH2 , MSH6 , and PMS2 mutations can help inform long term care strategies for patients with colorectal_and_endometrial_cancer .
8723353	0	MSH6	0,4	MSH2	88,92	MSH6	MSH2	851671(Tax:4932)	854063(Tax:4932)	Gene	Gene	START_ENTITY|appos|protein protein|acl:relcl|binds binds|xcomp|mismatches mismatches|nmod|heterodimer heterodimer|nmod|END_ENTITY	MSH6 , a Saccharomyces_cerevisiae protein that binds to mismatches as a heterodimer with MSH2 .
20696460	0	MSH6	114,118	MutS_homolog_6	98,112	MSH6	MutS homolog 6	260437(Tax:7955)	260437(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Sublethal levels of cadmium down-regulate the gene expression of DNA mismatch recognition protein MutS_homolog_6 -LRB- MSH6 -RRB- in zebrafish -LRB- Danio_rerio -RRB- embryos .
23374535	0	MSI-1	21,26	LGR-5	14,19	MSI-1	LGR-5	259272(Tax:10116)	299802(Tax:10116)	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Expression of LGR-5 , MSI-1 and DCAMKL-1 , putative stem cell markers , in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis : correlation with nuclear b-catenin .
26366338	0	MSI1	76,80	DCLK1	69,74	MSI1	DCLK1	4440	9201	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1 , MSI1 , LGR5 , and BMI1 .
26366338	0	MSI1	76,80	LGR5	82,86	MSI1	LGR5	4440	8549	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1 , MSI1 , LGR5 , and BMI1 .
26639245	0	MSI2	42,46	Musashi-2	31,40	MSI2	Musashi-2	124540	124540	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prognostic significance of the Musashi-2 -LRB- MSI2 -RRB- gene in childhood acute_lymphoblastic_leukemia .
11466217	0	MSJ-1	0,5	Hsp70-2	150,157	MSJ-1	Hsp70-2	15504(Tax:10090)	15512(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	MSJ-1 , a mouse testis-specific DnaJ protein , is highly expressed in haploid male germ cells and interacts with the testis-specific heat_shock protein Hsp70-2 .
15342353	0	MSJ-1	88,93	mUBPy	28,33	MSJ-1	mUBPy	15504(Tax:10090)	84092(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1 : the relation with the proteasome , acrosome , and centrosome in mouse male germ cells .
11553624	0	MSK1	0,4	STAT3	41,46	MSK1	STAT3	73086(Tax:10090)	20848(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells .
22733812	0	MSK1	181,185	mitogen_stress-activated_kinase_1	146,179	MSK1	mitogen stress-activated kinase 1	9252	9252	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Dimethyl_fumarate inhibits dendritic cell maturation via nuclear factor kB -LRB- NF-kB -RRB- and extracellular_signal-regulated_kinase_1_and_2 -LRB- ERK1/2 -RRB- and mitogen_stress-activated_kinase_1 -LRB- MSK1 -RRB- signaling .
23533666	0	MSK1/2	42,48	IL-10	19,24	MSK1/2	IL-10	73086;56613	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers .
19797274	0	MSK2	0,4	p53	14,17	MSK2	p53	8986	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	MSK2 inhibits p53 activity in the absence of stress .
16119455	0	MSL-1	124,129	hampin	88,94	MSL-1	hampin	35121(Tax:7227)	74026(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	-LSB- Tissue specificity of alternative splicing products of mouse mRNA encoding new protein hampin homologous to the Drosophila MSL-1 protein -RSB- .
20573372	0	MSLN	12,16	Mesothelin	0,10	MSLN	Mesothelin	10232	10232	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Mesothelin -LRB- MSLN -RRB- promoter is hypomethylated in malignant_mesothelioma , but its expression is not associated with methylation status of the promoter .
17909009	0	MSLN	47,51	mesothelin	35,45	MSLN	mesothelin	10232	10232	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High cancer-specific expression of mesothelin -LRB- MSLN -RRB- is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif .
8125014	0	MSN	37,40	moesin	24,30	MSN	moesin	4478	4478	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the human moesin gene -LRB- MSN -RRB- to chromosome region Xq11 .2 -- > q12 .
11002340	0	MSP	55,58	muscle-specific_protein	30,53	MSP	muscle-specific protein	259260(Tax:7955)	259260(Tax:7955)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Asynchronous activation of 10 muscle-specific_protein -LRB- MSP -RRB- genes during zebrafish somitogenesis .
26849376	0	MSP58	43,48	Microspherule_Protein	20,41	MSP58	Microspherule Protein	10445	10445	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of 58-kD Microspherule_Protein -LRB- MSP58 -RRB- is Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients .
15260083	0	MSR1	60,64	macrophage_scavenger_receptor_1	27,58	MSR1	macrophage scavenger receptor 1	4481	4481	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of the macrophage_scavenger_receptor_1 -LRB- MSR1 -RRB- gene in primary lung_cancer .
16541104	0	MSS4	83,87	Rab8	62,66	MSS4	Rab8	5877	4218	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Nucleotide exchange via local protein unfolding -- structure of Rab8 in complex with MSS4 .
11278283	0	MST	0,3	caspase	21,28	MST	caspase	55154	177391(Tax:6239)	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	MST , a physiological caspase substrate , highly sensitizes apoptosis both upstream and downstream of caspase activation .
12384512	0	MST1	33,37	Death-associated_protein_4	0,26	MST1	Death-associated protein 4	4485	5612	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Death-associated_protein_4 binds MST1 and augments MST1-induced apoptosis .
19962960	0	MST1	53,57	RASSF2	29,35	MST1	RASSF2	4485	9770	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity .
23893242	0	MST1	107,111	Scaffold_attachment_factor_B1	0,29	MST1	Scaffold attachment factor B1	4485	6294	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Scaffold_attachment_factor_B1 regulates the androgen_receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2 .
23893242	0	MST1	107,111	androgen_receptor	44,61	MST1	androgen receptor	4485	367	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Scaffold_attachment_factor_B1 regulates the androgen_receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2 .
17548476	0	MST1	53,57	c-Jun_N-terminal_kinase	18,41	MST1	c-Jun N-terminal kinase	4485	5599	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Activation of the c-Jun_N-terminal_kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis .
22195963	0	MST2	44,48	K-Ras	7,12	MST2	K-Ras	6788	3845	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras .
23459937	0	MST2	59,63	K-Ras	50,55	MST2	K-Ras	6788	3845	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics .
15618521	0	MST2	19,23	Raf-1	82,87	MST2	Raf-1	6788	5894	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|apoptosis apoptosis|nmod|END_ENTITY	Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1 .
23434407	0	MST4	17,21	MO25	38,42	MST4	MO25	51765	51719	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Structure of the MST4 in complex with MO25 provides insights into its activation mechanism .
17360971	0	MST4	43,47	PDCD10	0,6	MST4	PDCD10	51765	11235	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PDCD10 interacts with Ste20-related_kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway .
12212941	0	MSTN	60,64	myostatin	44,53	MSTN	myostatin	399534(Tax:9823)	399534(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of three SNPs in the porcine myostatin gene -LRB- MSTN -RRB- .
19392824	0	MSTN	66,70	myostatin	50,59	MSTN	myostatin	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A frameshift mutation in the coding region of the myostatin gene -LRB- MSTN -RRB- affects carcass conformation and fatness in Norwegian White Sheep -LRB- Ovis_aries -RRB- .
19505313	0	MSTN	52,56	myostatin	41,50	MSTN	myostatin	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An insertion in the coding region of the myostatin -LRB- MSTN -RRB- gene affects carcass conformation and fatness in the Norwegian Spaelsau -LRB- Ovis_aries -RRB- .
19799595	0	MSTN	43,47	myostatin	27,36	MSTN	myostatin	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the ovine myostatin gene -LRB- MSTN -RRB- and their association with growth and carcass traits in New Zealand Romney sheep .
20932346	0	MSTN	105,109	myostatin	94,103	MSTN	myostatin	100033832(Tax:9796)	100033832(Tax:9796)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A genome-wide SNP-association study confirms a sequence variant -LRB- g. 66493737C > T -RRB- in the equine myostatin -LRB- MSTN -RRB- gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses .
23613242	0	MSTN	37,41	myostatin	21,30	MSTN	myostatin	100860887	100860887	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of the myostatin gene -LRB- MSTN -RRB- and its relationship with growth traits in goat breeds .
24299184	0	MSTN	99,103	myostatin	88,97	MSTN	myostatin	100860887	100860887	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of 5 ' upstream region and investigation of TTTTA deletion in 5 ' UTR of myostatin -LRB- MSTN -RRB- gene in Indian goat breeds .
24796976	0	MSTN	86,90	myostatin	75,84	MSTN	myostatin	100125998(Tax:9986)	100125998(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new single nucleotide polymorphism in the rabbit -LRB- Oryctolagus_cuniculus -RRB- myostatin -LRB- MSTN -RRB- gene is associated with carcass composition traits .
25273961	0	MSTN	109,113	myostatin	98,107	MSTN	myostatin	100033832(Tax:9796)	100033832(Tax:9796)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the 227 bp short interspersed nuclear element -LRB- SINE -RRB- insertion of the promoter of the myostatin -LRB- MSTN -RRB- gene in different horse breeds .
26081604	0	MSTN	81,85	myostatin	65,74	MSTN	myostatin	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Two single nucleotide polymorphisms in the promoter of the ovine myostatin gene -LRB- MSTN -RRB- and their effect on growth and carcass muscle traits in New Zealand Romney sheep .
15192231	0	MSX1	0,4	H1b	29,32	MSX1	H1b	17701(Tax:10090)	56702(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis .
7664340	0	MSX1	0,4	myoD	14,18	MSX1	myoD	4487	4654	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids .
9733777	0	MSY-1	21,26	growth_hormone_receptor	62,85	MSY-1	growth hormone receptor	22608(Tax:10090)	14600(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Transcription factor MSY-1 regulates expression of the murine growth_hormone_receptor gene .
18606161	0	MSY2	41,45	CDC2A	0,5	MSY2	CDC2A	53422(Tax:10090)	12534(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	CDC2A -LRB- CDK1 -RRB- - mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation .
18041740	0	MT	96,98	V1/V2	80,85	MT	V1/V2	3176	28299;6983	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Stimulus-contrast-induced biases in activation order reveal interaction between V1/V2 and human MT + .
18687470	0	MT	44,46	metallothionein	27,42	MT	metallothionein	105931605	105931605	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Differential expression of metallothionein -LRB- MT -RRB- gene by trace metals and endocrine-disrupting chemicals in the hermaphroditic mangrove killifish , Kryptolebias_marmoratus .
19938953	0	MT-1	33,37	metallothionein-1	14,31	MT-1	metallothionein-1	24567(Tax:10116)	24567(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of metallothionein-1 -LRB- MT-1 -RRB- mRNA in the rat testes and liver after cadmium injection .
9372231	0	MT-I	32,36	metallothionein-I	13,30	MT-I	metallothionein-I	24567(Tax:10116)	24567(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Induction of metallothionein-I -LRB- MT-I -RRB- mRNA in primary astrocyte cultures is mediated by hypotonicity and not ethanol -LRB- EtOH -RRB- per se .
11077043	0	MT-II	220,225	MDR1	191,195	MT-II	MDR1	4502	5243	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Increased mRNA levels of xeroderma_pigmentosum_complementation_group_B -LRB- XPB -RRB- and Cockayne 's _ syndrome complementation group B -LRB- CSB -RRB- without increased mRNA levels of multidrug-resistance gene -LRB- MDR1 -RRB- or metallothionein-II -LRB- MT-II -RRB- in platinum-resistant human ovarian_cancer tissues .
21551541	0	MT-III	54,60	Growth_Inhibitory_Factor	22,46	MT-III	Growth Inhibitory Factor	117038(Tax:10116)	117038(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Altered expression of Growth_Inhibitory_Factor -LRB- GIF / MT-III -RRB- mRNA in the rat facial nucleus after facial_nerve_injury is closely related with facial function .
7482533	0	MT-III	48,54	metallothionein-III	27,46	MT-III	metallothionein-III	17751(Tax:10090)	17751(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive expression of metallothionein-III -LRB- MT-III -RRB- , but not MT-I , inhibits growth when cells become zinc deficient .
7708715	0	MT-MMP	40,46	Membrane-type_matrix_metalloproteinase	0,38	MT-MMP	Membrane-type matrix metalloproteinase	4323	4323	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Membrane-type_matrix_metalloproteinase -LRB- MT-MMP -RRB- gene is expressed in stromal cells of human colon , _ breast , _ and_head_and_neck_carcinomas .
9446829	0	MT-MMP-1	56,64	membrane-type_matrix_metalloproteinase-1	14,54	MT-MMP-1	membrane-type matrix metalloproteinase-1	4323	4323	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of membrane-type_matrix_metalloproteinase-1 -LRB- MT-MMP-1 -RRB- in early human placenta .
7559440	0	MT-MMP-2	69,77	membrane-type_matrix_metalloproteinase	29,67	MT-MMP-2	membrane-type matrix metalloproteinase	4324	4324	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the second membrane-type_matrix_metalloproteinase -LRB- MT-MMP-2 -RRB- gene from a human placenta cDNA library .
22856547	0	MT1	10,13	Kip1	68,72	MT1	Kip1	644314	1027	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Melatonin MT1 receptor-induced transcriptional up-regulation of p27 -LRB- Kip1 -RRB- in prostate_cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B -LRB- NF-kB -RRB- : potential implications on prostate_cancer chemoprevention and therapy .
15943478	0	MT1	88,91	MT2	49,52	MT1	MT2	644314	4502	Gene	Gene	antagonists|nmod|START_ENTITY antagonists|nummod|END_ENTITY	Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models .
24031039	0	MT1	95,98	MT2	100,103	MT1	MT2	644314	4502	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|dep|agonist agonist|nummod|END_ENTITY	Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1 / MT2 agonist and 5-HT2C antagonist .
15033980	0	MT1	141,144	MT4	105,108	MT1	MT4	17748(Tax:10090)	17752(Tax:10090)	Gene	Gene	features|nmod|START_ENTITY features|nmod|END_ENTITY	Functional differentiation in the mammalian metallothionein gene family : metal binding features of mouse MT4 and comparison with its paralog MT1 .
22632802	0	MT1-MMP	0,7	ADAM9	20,25	MT1-MMP	ADAM9	4323	8754	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis .
22065321	0	MT1-MMP	28,35	BST-2	0,5	MT1-MMP	BST-2	4323	684	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity .
25566991	0	MT1-MMP	50,57	CD44	0,4	MT1-MMP	CD44	4323	960	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CD44 regulates pancreatic_cancer_invasion through MT1-MMP .
20195390	0	MT1-MMP	34,41	COX-2	77,82	MT1-MMP	COX-2	17387(Tax:10090)	17709(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	The lectin concanavalin-A signals MT1-MMP catalytic independent induction of COX-2 through an IKKgamma/NF-kappaB-dependent pathway .
22971618	0	MT1-MMP	89,96	COX-2	111,116	MT1-MMP	COX-2	4323	4513	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Concanavalin-A triggers inflammatory response through JAK/STAT3 signalling and modulates MT1-MMP regulation of COX-2 in mesenchymal stromal cells .
19758589	0	MT1-MMP	46,53	EMMPRIN	0,7	MT1-MMP	EMMPRIN	4323	682	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	EMMPRIN and its ligand cyclophilin_A regulate MT1-MMP , MMP-9 and M-CSF during foam cell formation .
19112015	0	MT1-MMP	46,53	Endo180	0,7	MT1-MMP	Endo180	4323	9902	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate_cancer progression .
23629968	0	MT1-MMP	18,25	EphA2	0,5	MT1-MMP	EphA2	4323	1969	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion .
21738685	0	MT1-MMP	19,26	HIF-1a	12,18	MT1-MMP	HIF-1a	4323	3091	Gene	Gene	axis|compound|START_ENTITY regulates|nsubj|axis END_ENTITY|parataxis|regulates	A concerted HIF-1a / MT1-MMP signalling axis regulates the expression of the 3BP2 adaptor protein in hypoxic mesenchymal stromal cells .
18196535	0	MT1-MMP	88,95	IGF-1R	78,84	MT1-MMP	IGF-1R	4323	3480	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Differential localization of MT1-MMP in human prostate_cancer tissue : role of IGF-1R in MT1-MMP expression .
21856775	0	MT1-MMP	0,7	Kras	24,28	MT1-MMP	Kras	17387(Tax:10090)	16653(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	MT1-MMP cooperates with Kras -LRB- G12D -RRB- to promote pancreatic fibrosis through increased TGF-b signaling .
10206300	0	MT1-MMP	89,96	MMP-2	14,19	MT1-MMP	MMP-2	4323	4313	Gene	Gene	Gelatinase-A|appos|START_ENTITY Gelatinase-A|appos|END_ENTITY	Gelatinase-A -LRB- MMP-2 -RRB- , gelatinase-B -LRB- MMP-9 -RRB- and membrane_type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- are involved in different aspects of the pathophysiology of malignant_gliomas .
10685633	0	MT1-MMP	98,105	MMP-2	42,47	MT1-MMP	MMP-2	4323	4313	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Expression of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and of membrane-type-1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in transitional_cell_carcinoma of the upper urinary tract .
10840163	0	MT1-MMP	121,128	MMP-2	89,94	MT1-MMP	MMP-2	4323	4313	Gene	Gene	upregulates|appos|START_ENTITY upregulates|amod|matrix_metalloproteinase-2 matrix_metalloproteinase-2|dep|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor upregulates matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and membrane_type-1_MMP -LRB- MT1-MMP -RRB- in human head_and_neck_cancer cells .
10861447	0	MT1-MMP	111,118	MMP-2	152,157	MT1-MMP	MMP-2	4323	4313	Gene	Gene	membrane-type_matrix_metalloproteinase-1|appos|START_ENTITY membrane-type_matrix_metalloproteinase-1|appos|END_ENTITY	Expression of integrin_alpha -LRB- v -RRB- beta -LRB- 3 -RRB- correlates with activation of membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- and matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- in human melanoma cells in vitro and in vivo .
10878545	0	MT1-MMP	135,142	MMP-2	57,62	MT1-MMP	MMP-2	4323	4313	Gene	Gene	correlate|appos|START_ENTITY Expression|nmod|correlate Expression|nmod|END_ENTITY	Expression and activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and its co-localization with membrane-type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- correlate with melanoma progression .
10895974	0	MT1-MMP	158,165	MMP-2	86,91	MT1-MMP	MMP-2	4323	4313	Gene	Gene	membrane-type-1_matrix_metalloproteinase|dep|START_ENTITY expression|amod|membrane-type-1_matrix_metalloproteinase correlated|nmod|expression correlated|nsubjpass|activation activation|nmod|matrix_metalloproteinase-2 matrix_metalloproteinase-2|appos|END_ENTITY	Matrix metalloproteinases in human gliomas : activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- may be correlated with membrane-type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- expression .
11161720	0	MT1-MMP	0,7	MMP-2	90,95	MT1-MMP	MMP-2	4323	4313	Gene	Gene	activation|compound|START_ENTITY promotes|nsubj|activation promotes|dobj|maturation maturation|nmod|END_ENTITY	MT1-MMP initiates activation of pro-MMP-2 and integrin_alphavbeta3 promotes maturation of MMP-2 in breast_carcinoma cells .
11420151	0	MT1-MMP	67,74	MMP-2	14,19	MT1-MMP	MMP-2	4323	4313	Gene	Gene	expression|compound|START_ENTITY dependence|nmod|expression activation|dep|dependence activation|appos|END_ENTITY	Gelatinase A -LRB- MMP-2 -RRB- activation by skin fibroblasts : dependence on MT1-MMP expression and fibrillar collagen form .
11857380	0	MT1-MMP	56,63	MMP-2	108,113	MT1-MMP	MMP-2	4323	4313	Gene	Gene	membrane_type_1_matrix_metalloproteinase|appos|START_ENTITY Expression|nmod|membrane_type_1_matrix_metalloproteinase associated|nsubjpass|Expression associated|nmod|activation activation|compound|END_ENTITY	Expression of membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization .
12056775	0	MT1-MMP	82,89	MMP-2	40,45	MT1-MMP	MMP-2	4323	4313	Gene	Gene	type|appos|START_ENTITY membrane|dobj|type membrane|nsubj|Expression Expression|nmod|END_ENTITY	Expression of matrix_metalloprotease-2 -LRB- MMP-2 -RRB- and the activator membrane type 1 -LRB- MT1-MMP -RRB- in canine mammary carcinomas .
12480918	0	MT1-MMP	48,55	MMP-2	106,111	MT1-MMP	MMP-2	4323	4313	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|advcl|leading leading|nmod|accumulation accumulation|nmod|END_ENTITY	-LRB- - -RRB- Epigallocatechin-3-gallate directly inhibits MT1-MMP activity , leading to accumulation of nonactivated MMP-2 at the cell surface .
15297252	0	MT1-MMP	120,127	MMP-2	14,19	MT1-MMP	MMP-2	4323	4313	Gene	Gene	expression|nmod|START_ENTITY mediated|nmod|expression mediated|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of MMP-2 in response to vascular_injury is mediated by phosphatidylinositol 3-kinase-dependent expression of MT1-MMP .
17341206	0	MT1-MMP	25,32	MMP-2	57,62	MT1-MMP	MMP-2	4323	4313	Gene	Gene	dependent|amod|START_ENTITY activation|amod|dependent activation|nmod|cells cells|amod|END_ENTITY	Cell membrane-associated MT1-MMP dependent activation of MMP-2 in SiHa -LRB- human cervical_cancer -RRB- cells .
18627313	0	MT1-MMP	27,34	MMP-2	99,104	MT1-MMP	MMP-2	4323	4313	Gene	Gene	Dimerization|nmod|START_ENTITY step|nsubj|Dimerization step|nmod|activation activation|nmod|END_ENTITY	Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells .
22006368	0	MT1-MMP	82,89	MMP-2	69,74	MT1-MMP	MMP-2	4323	4313	Gene	Gene	START_ENTITY|nsubj|osteoblasts osteoblasts|acl:relcl|involves involves|xcomp|END_ENTITY	Mechanical forces-induced human osteoblasts differentiation involves MMP-2 / MMP-13 / MT1-MMP proteolytic cascade .
22140598	0	MT1-MMP	42,49	MMP-2	128,133	MT1-MMP	MMP-2	4323	4313	Gene	Gene	Membrane_type-1_matrix_metalloproteinase|appos|START_ENTITY correlates|nsubj|Membrane_type-1_matrix_metalloproteinase correlates|nmod|expression expression|nmod|END_ENTITY	Membrane_type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- correlates with the expression and activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- in inflammatory breast_cancer .
23166329	0	MT1-MMP	163,170	MMP-2	110,115	MT1-MMP	MMP-2	4323	4313	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Neurokinin-1_receptor directly mediates glioma cell migration by up-regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- .
23796708	0	MT1-MMP	0,7	MMP-2	18,23	MT1-MMP	MMP-2	4323	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells .
25317077	0	MT1-MMP	120,127	MMP-2	171,176	MT1-MMP	MMP-2	4323	4313	Gene	Gene	activation|appos|START_ENTITY activation|nmod|matrix_metalloproteinase_2 matrix_metalloproteinase_2|appos|END_ENTITY	High threshold of b1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase -LRB- MT1-MMP -RRB- activation of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- .
9062387	0	MT1-MMP	0,7	MMP-2	24,29	MT1-MMP	MMP-2	4323	4313	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|potential potential|compound|END_ENTITY	MT1-MMP correlates with MMP-2 activation potential seen after epithelial to mesenchymal transition in human breast_carcinoma cells .
9294857	0	MT1-MMP	61,68	MMP-2	27,32	MT1-MMP	MMP-2	4323	4313	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Co-ordinated expression of MMP-2 and its putative activator , MT1-MMP , in human placentation .
9748137	0	MT1-MMP	52,59	MMP-2	61,66	MT1-MMP	MMP-2	4323	4313	Gene	Gene	membrane_type_1_matrix_metalloproteinase|appos|START_ENTITY membrane_type_1_matrix_metalloproteinase|dep|messenger messenger|compound|END_ENTITY	Augmented membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- : MMP-2 messenger RNA ratio in gastric_carcinomas with poor prognosis .
9794486	0	MT1-MMP	86,93	MMP-2	141,146	MT1-MMP	MMP-2	81707(Tax:10116)	81686(Tax:10116)	Gene	Gene	membrane_type_matrix_metalloproteinase_1|appos|START_ENTITY membrane_type_matrix_metalloproteinase_1|appos|END_ENTITY	Coordinated and cell-specific regulation of membrane_type_matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- and its substrate matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- by physiological signals during follicular development and ovulation .
10995877	0	MT1-MMP	55,62	MMP-9	48,53	MT1-MMP	MMP-9	4323	4318	Gene	Gene	MMP-2|dep|START_ENTITY MMP-2|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
20620173	0	MT1-MMP	189,196	MT1-MMP	74,81	MT1-MMP	MT1-MMP	17387(Tax:10090)	17387(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulation|dep|expression regulation|nmod|END_ENTITY	Posttranslational regulation of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in mouse PTEN null prostate_cancer cells : Enhanced surface expression and differential O-glycosylation of MT1-MMP .
20620173	0	MT1-MMP	74,81	MT1-MMP	189,196	MT1-MMP	MT1-MMP	17387(Tax:10090)	17387(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|expression expression|nmod|END_ENTITY	Posttranslational regulation of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in mouse PTEN null prostate_cancer cells : Enhanced surface expression and differential O-glycosylation of MT1-MMP .
26204513	0	MT1-MMP	122,129	Membrane-Type_1_Matrix_Metalloproteinase	80,120	MT1-MMP	Membrane-Type 1 Matrix Metalloproteinase	4323	4323	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	The Oncogenic Response to MiR-335 Is Associated with Cell Surface Expression of Membrane-Type_1_Matrix_Metalloproteinase -LRB- MT1-MMP -RRB- Activity .
26204513	0	MT1-MMP	122,129	Membrane-Type_1_Matrix_Metalloproteinase	80,120	MT1-MMP	Membrane-Type 1 Matrix Metalloproteinase	4323	4323	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	The Oncogenic Response to MiR-335 Is Associated with Cell Surface Expression of Membrane-Type_1_Matrix_Metalloproteinase -LRB- MT1-MMP -RRB- Activity .
22315223	0	MT1-MMP	42,49	Membrane_type_1_matrix_metalloproteinase	0,40	MT1-MMP	Membrane type 1 matrix metalloproteinase	4323	4323	Gene	Gene	ubiquitination|appos|START_ENTITY ubiquitination|amod|END_ENTITY	Membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- ubiquitination at Lys581 increases cellular invasion through type I collagen .
23548673	0	MT1-MMP	14,21	PEDF	46,50	MT1-MMP	PEDF	4323	57104	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MT1-MMP and MMP-2 by the serpin PEDF : a promising new target for metastatic_cancer .
20620173	0	MT1-MMP	189,196	PTEN	92,96	MT1-MMP	PTEN	17387(Tax:10090)	19211(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulation|dep|expression regulation|nmod|MT1-MMP MT1-MMP|nmod|cells cells|compound|END_ENTITY	Posttranslational regulation of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in mouse PTEN null prostate_cancer cells : Enhanced surface expression and differential O-glycosylation of MT1-MMP .
20620173	0	MT1-MMP	74,81	PTEN	92,96	MT1-MMP	PTEN	17387(Tax:10090)	19211(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Posttranslational regulation of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in mouse PTEN null prostate_cancer cells : Enhanced surface expression and differential O-glycosylation of MT1-MMP .
14691682	0	MT1-MMP	89,96	Parathyroid_hormone	0,19	MT1-MMP	Parathyroid hormone	4323	5741	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Parathyroid_hormone inhibits the expression of membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- in osteoblast-like MG-63 cells .
18505793	0	MT1-MMP	71,78	RhoGAP	6,12	MT1-MMP	RhoGAP	4323	392	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2 .
17490812	0	MT1-MMP	18,25	SPARC	0,5	MT1-MMP	SPARC	4323	6678	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	SPARC upregulates MT1-MMP expression , MMP-2 activation , and the secretion and cleavage of galectin-3 in U87MG glioma cells .
10995877	0	MT1-MMP	55,62	TIMP-1	86,92	MT1-MMP	TIMP-1	4323	7076	Gene	Gene	MMP-2|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-2 matrix_metalloproteinases|appos|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
10995877	0	MT1-MMP	55,62	TIMP-2	94,100	MT1-MMP	TIMP-2	4323	7077	Gene	Gene	MMP-2|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-2 matrix_metalloproteinases|appos|TIMP-1 TIMP-1|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
12630911	0	MT1-MMP	169,176	TIMP-2	61,67	MT1-MMP	TIMP-2	4323	7077	Gene	Gene	determining|nmod|START_ENTITY motifs|acl|determining motifs|nmod|tissue_inhibitor_of_metalloproteinases_2 tissue_inhibitor_of_metalloproteinases_2|appos|END_ENTITY	Sequence motifs of tissue_inhibitor_of_metalloproteinases_2 -LRB- TIMP-2 -RRB- determining progelatinase_A -LRB- proMMP-2 -RRB- binding and activation by membrane-type metalloproteinase 1 -LRB- MT1-MMP -RRB- .
14729066	0	MT1-MMP	62,69	TIMP-2	0,6	MT1-MMP	TIMP-2	4323	7077	Gene	Gene	binding|nmod|START_ENTITY surface|amod|binding molecule|nmod|surface released|nmod|molecule released|nsubjpass|END_ENTITY	TIMP-2 is released as an intact molecule following binding to MT1-MMP on the cell surface .
15095267	0	MT1-MMP	36,43	TIMP-2	127,133	MT1-MMP	TIMP-2	4323	7077	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Activation of pro-MMP-2 mediated by MT1-MMP in human salivary_gland_carcinomas : possible regulation of pro-MMP-2 activation by TIMP-2 .
15451196	0	MT1-MMP	58,65	TIMP-2	119,125	MT1-MMP	TIMP-2	100861171	102178107	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Expression and localization of matrix_metalloproteinases -LRB- MT1-MMP , MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- during synepitheliochorial placentation of goats -LRB- Capra_hircus -RRB- .
26331622	0	MT1-MMP	24,31	TIMP-2	0,6	MT1-MMP	TIMP-2	4323	7077	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|compound|END_ENTITY	TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis .
9422789	0	MT1-MMP	153,160	TIMP-2	41,47	MT1-MMP	TIMP-2	4323	7077	Gene	Gene	membrane_type_1-matrix_metalloproteinase_1|dep|START_ENTITY binds|xcomp|membrane_type_1-matrix_metalloproteinase_1 binds|nsubj|Tissue_inhibitor_of_metalloproteinase-2 Tissue_inhibitor_of_metalloproteinase-2|appos|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- binds to the catalytic domain of the cell surface receptor , membrane_type_1-matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- .
9685743	0	MT1-MMP	158,165	TIMP-2	50,56	MT1-MMP	TIMP-2	4323	7077	Gene	Gene	membrane-type_matrix_metalloproteinase-1|appos|START_ENTITY catalyzed|nmod|membrane-type_matrix_metalloproteinase-1 catalyzed|nsubj|Role Role|nmod|END_ENTITY	Role of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in regulation of pro-gelatinase A activation catalyzed by membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- in human cancer cells .
11178970	0	MT1-MMP	67,74	TIMP-4	22,28	MT1-MMP	TIMP-4	4323	7079	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP .
19551841	0	MT1-MMP	29,36	Timp-2	0,6	MT1-MMP	Timp-2	4323	7077	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells .
26464124	0	MT1-MMP	16,23	Tip60	0,5	MT1-MMP	Tip60	4323	10524	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-kB pathway .
20021822	0	MT1-MMP	1,8	VEGF	22,26	MT1-MMP	VEGF	4323	7422	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	-LSB- MT1-MMP up-regulates VEGF expression in human breast_carcinoma MCF-7 cells and induces tumor angiogenesis -RSB- .
21062896	0	MT1-MMP	0,7	VEGF-A	18,24	MT1-MMP	VEGF-A	4323	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src .
22670674	0	MT1-MMP	0,7	VEGF-A	31,37	MT1-MMP	VEGF-A	4323	7422	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	MT1-MMP modulates bFGF-induced VEGF-A expression in corneal fibroblasts .
20589835	0	MT1-MMP	14,21	b-catenin	34,43	MT1-MMP	b-catenin	4323	1499	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of MT1-MMP activity by b-catenin in MDCK non-cancer and HT1080 cancer cells .
20471961	0	MT1-MMP	0,7	c-Src	56,61	MT1-MMP	c-Src	4323	6714	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix .
25317077	0	MT1-MMP	120,127	matrix_metalloproteinase_2	143,169	MT1-MMP	matrix metalloproteinase 2	4323	4313	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	High threshold of b1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase -LRB- MT1-MMP -RRB- activation of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- .
10822133	0	MT1-MMP	56,63	membrane-type_1_matrix_metalloproteinase	14,54	MT1-MMP	membrane-type 1 matrix metalloproteinase	4323	4323	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of membrane-type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- on prostate_cancer cell lines .
11757910	0	MT1-MMP	56,63	membrane-type_1_matrix_metalloproteinase	14,54	MT1-MMP	membrane-type 1 matrix metalloproteinase	100861171	100861171	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of membrane-type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats -LRB- Capra_hircus -RRB- .
9062392	0	MT1-MMP	55,62	membrane-type_matrix_metalloproteinase_1	13,53	MT1-MMP	membrane-type matrix metalloproteinase 1	4323	4323	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of membrane-type_matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- expression in human fibroblasts by breast_adenocarcinoma cells .
16525713	0	MT1-MMP	56,63	membrane_type-1_matrix_metalloproteinase	14,54	MT1-MMP	membrane type-1 matrix metalloproteinase	4323	4323	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of membrane_type-1_matrix_metalloproteinase , MT1-MMP in human breast_cancer and its impact on invasiveness of breast_cancer cells .
19855192	0	MT1-MMP	64,71	membrane_type-1_matrix_metalloproteinase	22,62	MT1-MMP	membrane type-1 matrix metalloproteinase	4323	4323	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A novel and selective membrane_type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- inhibitor reduces cancer cell motility and tumor growth .
11949783	0	MT1-MMP	78,85	membrane_type_1-matrix_metalloproteinase	36,76	MT1-MMP	membrane type 1-matrix metalloproteinase	81707(Tax:10116)	81707(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in osteoclasts in vivo .
16407177	0	MT1-MMP	126,133	membrane_type_1_matrix_metalloproteinase	67,107	MT1-MMP	membrane type 1 matrix metalloproteinase	4323	4323	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Type I collagen abrogates the clathrin-mediated internalization of membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- via the MT1-MMP hemopexin domain .
22002053	0	MT1-MMP	117,124	membrane_type_1_matrix_metalloproteinase	75,115	MT1-MMP	membrane type 1 matrix metalloproteinase	4323	4323	Gene	Gene	translocation|compound|START_ENTITY translocation|amod|END_ENTITY	Fluid shear stress and sphingosine_1-phosphate activate calpain to promote membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- membrane translocation and endothelial invasion into three-dimensional collagen matrices .
18080692	0	MT1-MMP	58,65	membrane_type_I_matrix_metalloproteinase	16,56	MT1-MMP	membrane type I matrix metalloproteinase	4323	4323	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Correlation of membrane_type_I_matrix_metalloproteinase -LRB- MT1-MMP -RRB- expression with clinicomorphological features of tumor front in squamous_cell_carcinoma_of_the_larynx -RSB- .
18230350	0	MT1-MMP	76,83	membrane_type_matrix_metalloproteinase-1	34,74	MT1-MMP	membrane type matrix metalloproteinase-1	4323	4323	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Association between serum soluble membrane_type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- levels and bone_mineral_density , and biochemical markers in postmenopausal women .
9481784	0	MT1-MMP	73,80	membrane_type_matrix_metalloproteinase-1	31,71	MT1-MMP	membrane type matrix metalloproteinase-1	4323	4323	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of membrane_type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- in trophoblast cells of cultured mouse blastocysts and ectoplacental cones .
25261601	0	MT1DP	38,43	YAP	71,74	MT1DP	YAP	326343	10413	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Tumor suppressor long non-coding RNA , MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver_cancer cells .
15369632	0	MT1F	45,49	metallothionein-1F	25,43	MT1F	metallothionein-1F	4494	4494	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The relationship between metallothionein-1F -LRB- MT1F -RRB- gene and hepatocellular_carcinoma .
15147870	0	MT1_MMP	31,38	MMP_2	63,68	MT1 MMP	MMP 2	4323	4313	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Cellular cholesterol regulates MT1_MMP dependent activation of MMP_2 via MEK-1 in HT1080 fibrosarcoma cells .
15943478	0	MT2	49,52	MT1	88,91	MT2	MT1	4502	644314	Gene	Gene	antagonists|nummod|START_ENTITY antagonists|nmod|END_ENTITY	Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models .
24031039	0	MT2	100,103	MT1	95,98	MT2	MT1	4502	644314	Gene	Gene	agonist|nummod|START_ENTITY Synthesis|dep|agonist Synthesis|nmod|END_ENTITY	Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1 / MT2 agonist and 5-HT2C antagonist .
10884567	0	MT2	93,96	mt1	82,85	MT2	mt1	17750(Tax:10090)	17748(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Anxiolytic-like properties of melatonin receptor agonists in mice : involvement of mt1 and/or MT2 receptors in the regulation of emotional responsiveness .
10968369	0	MT2	118,121	mt1	101,104	MT2	mt1	4544	4543	Gene	Gene	Mel-1a|appos|START_ENTITY Mel-1a|appos|END_ENTITY	Production and characterization of antibodies directed against the human melatonin receptors Mel-1a -LRB- mt1 -RRB- and Mel-1b -LRB- MT2 -RRB- .
9179500	0	MT2-MMP	62,69	membrane-type_matrix_metalloproteinase-2	20,60	MT2-MMP	membrane-type matrix metalloproteinase-2	4324	4324	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Assignment of human membrane-type_matrix_metalloproteinase-2 -LRB- MT2-MMP -RRB- gene to 16q12 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis .
26456220	0	MT2A	22,26	HMBOX1	0,6	MT2A	HMBOX1	4502	79618	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells .
10913150	0	MT3	45,48	quinone_reductase_2	56,75	MT3	quinone reductase 2	4504	4835	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the melatonin-binding site MT3 as the quinone_reductase_2 .
9796998	0	MT3-MMP	60,67	membrane-type_3_matrix_metalloproteinase	18,58	MT3-MMP	membrane-type 3 matrix metalloproteinase	4325	4325	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the membrane-type_3_matrix_metalloproteinase -LRB- MT3-MMP -RRB- in human brain tissues .
15033980	0	MT4	105,108	MT1	141,144	MT4	MT1	17752(Tax:10090)	17748(Tax:10090)	Gene	Gene	features|nmod|START_ENTITY features|nmod|END_ENTITY	Functional differentiation in the mammalian metallothionein gene family : metal binding features of mouse MT4 and comparison with its paralog MT1 .
10727639	0	MT5-MMP	70,77	membrane_type-5_matrix_metalloproteinase	28,68	MT5-MMP	membrane type-5 matrix metalloproteinase	83513(Tax:10116)	83513(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Developmental regulation of membrane_type-5_matrix_metalloproteinase -LRB- MT5-MMP -RRB- expression in the rat nervous system .
10363975	0	MT5-MMP	45,52	progelatinase_a	88,103	MT5-MMP	progelatinase a	10893	4313	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Identification and characterization of human MT5-MMP , a new membrane-bound activator of progelatinase_a overexpressed in brain_tumors .
21813470	0	MTA1	91,95	C-myc	104,109	MTA1	C-myc	9112	4609	Gene	Gene	upregulating|dobj|START_ENTITY upregulating|nmod|END_ENTITY	Overexpression of EIF5A2 promotes colorectal_carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymaltransition .
27044752	0	MTA1	37,41	Granulocyte_Colony_Stimulating_Factor	45,82	MTA1	Granulocyte Colony Stimulating Factor	9112	1440	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of regulation of MTA1 by Granulocyte_Colony_Stimulating_Factor .
25705708	0	MTA1	0,4	HIF1a	23,28	MTA1	HIF1a	9112	3091	Gene	Gene	Regulate|nsubj|START_ENTITY Regulate|dobj|Expression Expression|compound|END_ENTITY	MTA1 and MTA3 Regulate HIF1a Expression in Hypoxia-Treated Human Trophoblast Cell Line HTR8/Svneo .
12527756	0	MTA1	0,4	MAT1	20,24	MTA1	MAT1	9112	4331	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	MTA1 interacts with MAT1 , a cyclin-dependent kinase-activating kinase complex ring finger factor , and regulates estrogen receptor transactivation functions .
16617102	0	MTA1	0,4	breast_cancer_amplified_sequence_3	37,71	MTA1	breast cancer amplified sequence 3	9112	54828	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	MTA1 , a transcriptional activator of breast_cancer_amplified_sequence_3 .
18679832	0	MTA1	67,71	estrogen_receptor_alpha	15,38	MTA1	estrogen receptor alpha	116870(Tax:10090)	13982(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Interaction of estrogen_receptor_alpha transactivation domain with MTA1 decreases in old mouse brain .
16733204	0	MTA1	47,51	metastasis-associated_protein_1	14,45	MTA1	metastasis-associated protein 1	9112	9112	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of metastasis-associated_protein_1 -LRB- MTA1 -RRB- in benign endometrium and endometrial_adenocarcinomas .
25929737	0	MTA2	0,4	IL-11	80,85	MTA2	IL-11	9219	3589	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	MTA2 enhances colony formation and tumor growth of gastric_cancer cells through IL-11 .
23510993	0	MTA3	0,4	CGB5	15,19	MTA3	CGB5	57504	93659	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|genes genes|compound|END_ENTITY	MTA3 regulates CGB5 and Snail genes in trophoblast .
24293376	0	MTA3	68,72	MiR-495	0,7	MTA3	MiR-495	57504	574453	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3 .
26088413	0	MTAP	49,53	Methylthioadenosine_Phosphorylase	14,47	MTAP	Methylthioadenosine Phosphorylase	4507	4507	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Methylthioadenosine_Phosphorylase -LRB- MTAP -RRB- in Pilocytic_Astrocytomas .
16081515	0	MTAP	110,114	methylthioadenosine_phosphorylase	75,108	MTAP	methylthioadenosine phosphorylase	4507	4507	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine_phosphorylase -LRB- MTAP -RRB- expression in hepatocellular_carcinoma .
19622299	0	MTAP	50,54	methylthioadenosine_phosphorylase	15,48	MTAP	methylthioadenosine phosphorylase	4507	4507	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Expression of methylthioadenosine_phosphorylase -LRB- MTAP -RRB- gene and demethylation of its promoter in human colorectal_cancer -RSB- .
21301207	0	MTAP	62,66	methylthioadenosine_phosphorylase	27,60	MTAP	methylthioadenosine phosphorylase	66902(Tax:10090)	66902(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Targeting tumors that lack methylthioadenosine_phosphorylase -LRB- MTAP -RRB- activity : current strategies .
21356366	0	MTAP	54,58	methylthioadenosine_phosphorylase	19,52	MTAP	methylthioadenosine phosphorylase	4507	4507	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of methylthioadenosine_phosphorylase -LRB- MTAP -RRB- induces progression of hepatocellular_carcinoma via accumulation of 5 ' - deoxy-5 ' - methylthioadenosine -LRB- MTA -RRB- .
15632057	0	MTBP	39,43	p53	14,17	MTBP	p53	27085	7157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of p53 and MDM2 activity by MTBP .
23059707	0	MTBP	39,43	p53	32,35	MTBP	p53	27085	7157	Gene	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	The enhancement of stability of p53 in MTBP induced p53-MDM2 regulatory network .
22416135	0	MTCH2	124,129	mitochondrial_carrier_homologue_2	89,122	MTCH2	mitochondrial carrier homologue 2	23788	23788	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Molecular basis of the interaction between proapoptotic truncated BID -LRB- tBID -RRB- protein and mitochondrial_carrier_homologue_2 -LRB- MTCH2 -RRB- protein : key players in mitochondrial death pathway .
26692143	0	MTCH_1	99,105	PSAP	140,144	MTCH 1	PSAP	23787	5660	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Early_growth_response_1 -LRB- EGR-1 -RRB- is a transcriptional regulator of mitochondrial_carrier_homolog_1 -LRB- MTCH_1 -RRB- / presenilin_1-associated protein -LRB- PSAP -RRB- .
26692143	0	MTCH_1	99,105	mitochondrial_carrier_homolog_1	66,97	MTCH 1	mitochondrial carrier homolog 1	23787	23787	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Early_growth_response_1 -LRB- EGR-1 -RRB- is a transcriptional regulator of mitochondrial_carrier_homolog_1 -LRB- MTCH_1 -RRB- / presenilin_1-associated protein -LRB- PSAP -RRB- .
26236947	0	MTDH	14,18	AMPK	0,4	MTDH	AMPK	92140	5564	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	AMPK inhibits MTDH expression via GSK3b and SIRT1 activation : potential role in triple_negative_breast_cancer cell proliferation .
26236947	0	MTDH	14,18	GSK3b	34,39	MTDH	GSK3b	92140	2932	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	AMPK inhibits MTDH expression via GSK3b and SIRT1 activation : potential role in triple_negative_breast_cancer cell proliferation .
26176806	0	MTDH	98,102	metadherin	86,96	MTDH	metadherin	92140	92140	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin -LRB- MTDH -RRB- expression .
26920759	0	MTE1	0,4	MPH1	20,24	MTE1	MPH1	10965	7272	Gene	Gene	Functions|compound|START_ENTITY Functions|nmod|END_ENTITY	MTE1 Functions with MPH1 in Double-Strand Break Repair .
16619271	0	MTF-1	49,54	metal-responsive_transcription_factor-1	8,47	MTF-1	metal-responsive transcription factor-1	17764(Tax:10090)	17764(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of metal-responsive_transcription_factor-1 -LRB- MTF-1 -RRB- in EGF-dependent DNA synthesis in primary hepatocytes .
8467794	0	MTF-1	28,33	metallothionein_I	54,71	MTF-1	metallothionein I	17764(Tax:10090)	17748(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Cloned transcription factor MTF-1 activates the mouse metallothionein_I promoter .
19021535	0	MTF1	76,80	metal-regulatory_transcription_factor_1	35,74	MTF1	metal-regulatory transcription factor 1	195821(Tax:7955)	195821(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Zinc-controlled gene expression by metal-regulatory_transcription_factor_1 -LRB- MTF1 -RRB- in a model vertebrate , the zebrafish .
15231665	0	MTG16	26,31	ETO-2	19,24	MTG16	ETO-2	863	863	Gene	Gene	interactions|appos|START_ENTITY interactions|amod|END_ENTITY	AML1-ETO decreases ETO-2 -LRB- MTG16 -RRB- interactions with nuclear_receptor_corepressor , an effect that impairs granulocyte differentiation .
19646530	0	MTGR1	43,48	NEUROG2	23,30	MTGR1	NEUROG2	9139	63973	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis .
22556419	0	MTH1	116,120	MTH3	6,10	MTH1	MTH3	4521	79873	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Human MTH3 -LRB- NUDT18 -RRB- protein hydrolyzes oxidized forms of guanosine and deoxyguanosine_diphosphates : comparison with MTH1 and MTH2 .
22556419	0	MTH3	6,10	MTH1	116,120	MTH3	MTH1	79873	4521	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Human MTH3 -LRB- NUDT18 -RRB- protein hydrolyzes oxidized forms of guanosine and deoxyguanosine_diphosphates : comparison with MTH1 and MTH2 .
9660395	0	MTHFR	5,10	ACE	0,3	MTHFR	ACE	4524	1636	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|advmod|END_ENTITY	ACE , MTHFR , factor_V_Leiden , and APOE polymorphisms in patients with vascular and Alzheimer 's _ dementia .
21461956	0	MTHFR	6,11	APOE	0,4	MTHFR	APOE	4524	348	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|advmod|END_ENTITY	APOE , MTHFR , LDLR and ACE polymorphisms among Angami and Lotha Naga populations of Nagaland , India .
16564429	0	MTHFR	62,67	COMT	104,108	MTHFR	COMT	4524	1312	Gene	Gene	methylenetetrahydrofolate_reductase|appos|START_ENTITY methylenetetrahydrofolate_reductase|appos|END_ENTITY	Genetic investigation of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and catechol-O-methyl_transferase -LRB- COMT -RRB- in multiple_sclerosis .
20373852	0	MTHFR	77,82	CYP1A1	30,36	MTHFR	CYP1A1	4524	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTHFR	77,82	CYP2C19	46,53	MTHFR	CYP2C19	4524	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTHFR	77,82	CYP2C9	38,44	MTHFR	CYP2C9	4524	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTHFR	77,82	CYP2D6	55,61	MTHFR	CYP2D6	4524	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTHFR	77,82	GSTM1	70,75	MTHFR	GSTM1	4524	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTHFR	77,82	GSTT1	63,68	MTHFR	GSTT1	4524	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
11807892	0	MTHFR	162,167	MTHFR	62,67	MTHFR	MTHFR	4524	4524	Gene	Gene	site|amod|START_ENTITY report|nmod|site polymorphisms|dep|report polymorphisms|nmod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- in ethnic populations in Texas ; a report of a novel MTHFR polymorphic site , G1793A .
11807892	0	MTHFR	62,67	MTHFR	162,167	MTHFR	MTHFR	4524	4524	Gene	Gene	methylenetetrahydrofolate_reductase|appos|START_ENTITY polymorphisms|nmod|methylenetetrahydrofolate_reductase polymorphisms|dep|report report|nmod|site site|amod|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- in ethnic populations in Texas ; a report of a novel MTHFR polymorphic site , G1793A .
11807892	0	MTHFR	162,167	MTRR	104,108	MTHFR	MTRR	4524	4552	Gene	Gene	site|amod|START_ENTITY report|nmod|site polymorphisms|dep|report polymorphisms|nmod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|appos|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- in ethnic populations in Texas ; a report of a novel MTHFR polymorphic site , G1793A .
11807892	0	MTHFR	62,67	MTRR	104,108	MTHFR	MTRR	4524	4552	Gene	Gene	methylenetetrahydrofolate_reductase|appos|START_ENTITY methylenetetrahydrofolate_reductase|appos|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- in ethnic populations in Texas ; a report of a novel MTHFR polymorphic site , G1793A .
12810988	0	MTHFR	14,19	MTRR	26,30	MTHFR	MTRR	4524	4552	Gene	Gene	Mutations|nmod|START_ENTITY -RSB-|nsubj|Mutations -RSB-|nsubj|genes genes|amod|END_ENTITY	-LSB- Mutations of MTHFR , MTR , MTRR genes as high risk factors for neural tube defects -RSB- .
19035314	0	MTHFR	37,42	MTRR	79,83	MTHFR	MTRR	4524	4552	Gene	Gene	Methylenetetrahydrofolate_reductase|dep|START_ENTITY Methylenetetrahydrofolate_reductase|dep|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- gene polymorphisms as risk factors for hepatocellular_carcinoma in a Korean population .
20373852	0	MTHFR	77,82	MTRR	84,88	MTHFR	MTRR	4524	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21438757	0	MTHFR	15,20	MTRR	27,31	MTHFR	MTRR	4524	4552	Gene	Gene	RFC1|compound|START_ENTITY RFC1|appos|END_ENTITY	Association of MTHFR , MTR , MTRR , RFC1 , and DHFR gene polymorphisms with susceptibility to sporadic colon_cancer .
25322900	0	MTHFR	79,84	MTRR	121,125	MTHFR	MTRR	4524	4552	Gene	Gene	methylenetetrahydrofolate_reductase|dep|START_ENTITY polymorphisms|amod|methylenetetrahydrofolate_reductase polymorphisms|appos|END_ENTITY	Riboflavin status modifies the effects of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- polymorphisms on homocysteine .
25634728	0	MTHFR	112,117	MTRR	151,155	MTHFR	MTRR	4524	4552	Gene	Gene	Supplementation|dep|START_ENTITY Complications|ccomp|Supplementation Complications|nsubj|Methionine_Synthase_Reductase Methionine_Synthase_Reductase|appos|END_ENTITY	Individualized Supplementation of Folic Acid According to Polymorphisms of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- , Methionine_Synthase_Reductase -LRB- MTRR -RRB- Reduced Pregnant Complications .
26687138	0	MTHFR	70,75	Methylenetetrahydrafolate_Reductase_Gene_Polymorphism	15,68	MTHFR	Methylenetetrahydrafolate Reductase Gene Polymorphism	4524	4524	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of Methylenetetrahydrafolate_Reductase_Gene_Polymorphism -LRB- MTHFR -RRB- in Patients with Gallbladder_Cancer .
22952513	0	MTHFR	43,48	Methylenetetrahydrofolate_Reductase	6,41	MTHFR	Methylenetetrahydrofolate Reductase	4524	4524	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	C677T Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- Gene Polymorphism in Schizophrenia and Bipolar_Disorder : An Association Study in Iranian Population .
23725631	0	MTHFR	54,59	Methylenetetrahydrofolate_Reductase	17,52	MTHFR	Methylenetetrahydrofolate Reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Determination of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- gene polymorphism in Turkish patients with nonsyndromic_cleft_lip_and_palate .
25745606	0	MTHFR	61,66	Methylenetetrahydrofolate_Reductase	24,59	MTHFR	Methylenetetrahydrofolate Reductase	4524	4524	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Common Mutations of the Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- Gene in Non-Syndromic Cleft Lips and Palates Children in North-West of Iran .
10928104	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism increases the risk of cervical_intraepithelial_neoplasia .
15300362	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism is associated with osteoporotic_vertebral_fractures , but is a weak predictor of BMD .
15385937	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene 677C > T and 1298A > C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic_lymphocytic_leukemia .
15551285	0	MTHFR	42,47	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- polymorphisms and reduced risk of malignant_lymphoma .
15916056	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism -LRB- C677T -RRB- in relation to homocysteine concentration in overweight and obese Thais .
18715139	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism is associated with spinal BMD in 9-year-old children .
20078613	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphisms and FOLFOX response in colorectal_cancer patients .
21489764	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene C677T , A1298C and G1793A polymorphisms : association with risk for clear_cell_renal_cell_carcinoma and tumour behaviour in men .
23395424	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene C677T polymorphism and risk of preeclampsia : an updated meta-analysis based on 51 studies .
24140489	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphisms and susceptibility to ischemic_stroke : a meta-analysis .
24229535	0	MTHFR	37,42	Methylenetetrahydrofolate_reductase	0,35	MTHFR	Methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C/T polymorphism is associated with antipsychotic-induced weight_gain in first-episode schizophrenia .
20373852	0	MTHFR	77,82	NAT2	96,100	MTHFR	NAT2	4524	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTHFR	77,82	NQO1	90,94	MTHFR	NQO1	4524	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
9450474	0	MTHFR	103,108	cytochrome-P450_1A1	27,46	MTHFR	cytochrome-P450 1A1	4524	1543	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Germ line polymorphisms in cytochrome-P450_1A1 -LRB- C4887 CYP1A1 -RRB- and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- genes and endometrial_cancer susceptibility .
10196703	0	MTHFR	109,114	methylene-tetrahydrofolate_reductase	66,102	MTHFR	methylene-tetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate_reductase gene -LRB- MTHFR -RRB- .
25299110	0	MTHFR	99,104	methylenetetrahydrofolate-reductase	62,97	MTHFR	methylenetetrahydrofolate-reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ethnic variation of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase -LRB- MTHFR -RRB- gene in southwestern Mexico .
10462631	0	MTHFR	112,117	methylenetetrahydrofolate_reductase	75,110	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Development of an internal restriction control in the PCR detection of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T mutation .
10666493	0	MTHFR	52,57	methylenetetrahydrofolate_reductase	15,50	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism with bone_mineral_density in postmenopausal Japanese women .
10679944	0	MTHFR	84,89	methylenetetrahydrofolate_reductase	47,82	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of six novel mutations in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in patients with homocystinuria .
10695265	0	MTHFR	137,142	methylenetetrahydrofolate_reductase	100,135	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene -LRB- C677T -RRB- .
10780318	0	MTHFR	155,160	methylenetetrahydrofolate_reductase	118,153	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of vitamin_B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene .
10860300	0	MTHFR	55,60	methylenetetrahydrofolate_reductase	18,53	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Apolipoprotein_E , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- mutation and the risk of senile_dementia -- an epidemiological study using the polymerase chain reaction -LRB- PCR -RRB- method .
11080594	0	MTHFR	57,62	methylenetetrahydrofolate_reductase	20,55	MTHFR	methylenetetrahydrofolate reductase	17769(Tax:10090)	4524	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	The human and mouse methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- genes : genomic organization , mRNA structure and linkage to the CLCN6 gene .
11142765	0	MTHFR	102,107	methylenetetrahydrofolate_reductase	65,100	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ethnic differences in the frequency of the C677T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in healthy Israeli populations .
11468972	0	MTHFR	63,68	methylenetetrahydrofolate_reductase	21,56	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Polymorphism of the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and incidence of hyperhomocysteinemia-related diseases -RSB- .
11589919	0	MTHFR	100,105	methylenetetrahydrofolate_reductase	63,98	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene : a study in an Italian population with dementia .
11692165	0	MTHFR	68,73	methylenetetrahydrofolate_reductase	31,66	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A second common variant in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and its relationship to MTHFR enzyme activity , homocysteine , and cardiovascular_disease risk .
12027572	0	MTHFR	68,73	methylenetetrahydrofolate_reductase	31,66	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 677C _ -- > _ T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in epileptic patients affected by systemic_lupus_erythematosus .
12540022	0	MTHFR	41,46	methylenetetrahydrofolate_reductase	4,39	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in colorectal_cancer : role in tumor development and significance of allelic loss in tumor progression .
14614398	0	MTHFR	81,86	methylenetetrahydrofolate_reductase	44,79	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prevalence of the C677T substitution of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in Wisconsin .
15040829	0	MTHFR	81,86	methylenetetrahydrofolate_reductase	44,79	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a common polymorphism in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with bone phenotypes depends on plasma folate status .
15114606	0	MTHFR	95,100	methylenetetrahydrofolate_reductase	58,93	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene among the Lebanese population .
15259035	0	MTHFR	63,68	methylenetetrahydrofolate_reductase	26,61	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Metabolic effects and the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism associated with neural_tube_defects in southern Brazil .
16379339	0	MTHFR	50,55	methylenetetrahydrofolate_reductase	13,48	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism , B vitamins and other factors on plasma homocysteine and risk of thromboembolic_disease in Chinese .
16545905	0	MTHFR	75,80	methylenetetrahydrofolate_reductase	38,73	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of 677C > T polymorphism of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with bipolar_disorder and schizophrenia .
16758123	0	MTHFR	52,57	methylenetetrahydrofolate_reductase	15,50	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphisms with genetic susceptibility to gastric_cancer : a meta-analysis .
16832597	0	MTHFR	55,60	methylenetetrahydrofolate_reductase	18,53	MTHFR	methylenetetrahydrofolate reductase	17769(Tax:10090)	17769(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY END_ENTITY|dobj|effect	Folic_acid rivals methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene-silencing effect on MEPM cell proliferation and apoptosis .
16936070	0	MTHFR	72,77	methylenetetrahydrofolate_reductase	30,65	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The C677T polymorphism in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- , maternal use of folic_acid supplements , and risk of isolated_clubfoot : A case-parent-triad analysis .
17111187	0	MTHFR	59,64	methylenetetrahydrofolate_reductase	17,52	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and the age of onset of sporadic_colorectal_adenocarcinoma .
17344026	0	MTHFR	52,57	methylenetetrahydrofolate_reductase	15,50	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Effects of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism on executive function in schizophrenia .
18053312	0	MTHFR	58,63	methylenetetrahydrofolate_reductase	21,56	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene , intakes of folate and related B_vitamins and colorectal_cancer : a case-control study in a population with relatively low folate intake .
18499331	0	MTHFR	53,58	methylenetetrahydrofolate_reductase	16,51	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Carriage of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow .
18979159	0	MTHFR	88,93	methylenetetrahydrofolate_reductase	51,86	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The synergistic effect of bone mineral density and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism -LRB- C677T -RRB- on fractures .
19421414	0	MTHFR	67,72	methylenetetrahydrofolate_reductase	25,60	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the methylenetetrahydrofolate_reductase gene , MTHFR , does not alter the risk of visual_failure in Leber 's _ hereditary_optic_neuropathy .
19746410	0	MTHFR	57,62	methylenetetrahydrofolate_reductase	20,55	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism and age of onset in schizophrenia .
19846566	0	MTHFR	70,75	methylenetetrahydrofolate_reductase	33,68	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Meta - and pooled analyses of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism and colorectal_cancer : a HuGE-GSEC review .
20692813	0	MTHFR	82,87	methylenetetrahydrofolate_reductase	40,75	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gene-wide association study between the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and schizophrenia in the Japanese population , with an updated meta-analysis on currently available data .
21270470	0	MTHFR	50,55	methylenetetrahydrofolate_reductase	8,43	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- 677C > T polymorphism in pediatric cerebrovascular_disorders .
21334398	0	MTHFR	69,74	methylenetetrahydrofolate_reductase	27,62	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variability in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- affects clinical expression of Wilson 's _ disease .
21506883	0	MTHFR	125,130	methylenetetrahydrofolate_reductase	88,123	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Age at menarche and menopause is not associated with two common genetic variants in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene .
21732284	0	MTHFR	83,88	methylenetetrahydrofolate_reductase	46,81	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Risk of colorectal_cancer associated with the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism in the Kashmiri population .
22103601	0	MTHFR	88,93	methylenetetrahydrofolate_reductase	51,86	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the C677T polymorphism in the human methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with the genetic predisposition for type_2_diabetes_mellitus in a Moroccan population .
22108397	0	MTHFR	72,77	methylenetetrahydrofolate_reductase	35,70	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Comparison of the frequency of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism in depressed versus nondepressed patients .
22492374	0	MTHFR	58,63	methylenetetrahydrofolate_reductase	21,56	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Prospective study of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- variant C677T and risk of all-cause and cardiovascular_disease mortality among 6000 US adults .
22528943	0	MTHFR	47,52	methylenetetrahydrofolate_reductase	10,45	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphisms on methotrexate-induced toxicities in acute_lymphoblastic_leukemia : a meta-analysis .
22846211	0	MTHFR	92,97	methylenetetrahydrofolate_reductase	55,90	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serum homocysteine , vitamin_B12 , folic_acid levels and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphism in vitiligo .
23161188	0	MTHFR	75,80	methylenetetrahydrofolate_reductase	38,73	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequency of the C677T variant of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in patients with migraine with or without aura - a preliminary report .
24247802	0	MTHFR	198,203	methylenetetrahydrofolate_reductase	161,196	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new and improved method based on polymerase chain reaction-restriction fragment length polymorphism -LRB- PCR-RFLP -RRB- for the determination of A1298C mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene .
24366618	0	MTHFR	92,97	methylenetetrahydrofolate_reductase	55,90	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of 677C _ > _ T polymorphism a single substitution in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in North Indian infertile men .
24472005	0	MTHFR	71,76	methylenetetrahydrofolate_reductase	29,64	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and risk of vitiligo in Han Chinese populations : a genotype-phenotype correlation study .
25294236	0	MTHFR	62,67	methylenetetrahydrofolate_reductase	25,60	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and susceptibility to depression in Asian population : a systematic meta-analysis .
25412139	0	MTHFR	82,87	methylenetetrahydrofolate_reductase	45,80	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of C677T transition of the human methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with male_infertility .
25832791	0	MTHFR	62,67	methylenetetrahydrofolate_reductase	25,60	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and susceptibility to depression in Asian population : a systematic meta-analysis .
25887077	0	MTHFR	63,68	methylenetetrahydrofolate_reductase	21,56	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- are associated with susceptibility to adult acute_myeloid_leukemia in a Chinese population .
25887077	0	MTHFR	63,68	methylenetetrahydrofolate_reductase	21,56	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- are associated with susceptibility to adult acute_myeloid_leukemia in a Chinese population .
25966188	0	MTHFR	52,57	methylenetetrahydrofolate_reductase	15,50	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphism with ischemic_stroke in the Eastern Chinese Han population .
26177556	0	MTHFR	62,67	methylenetetrahydrofolate_reductase	25,60	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and susceptibility to depression in Asian population : a systematic meta-analysis .
26599798	0	MTHFR	109,114	methylenetetrahydrofolate_reductase	72,107	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Associations between asymmetric_dimethylarginine , homocysteine , and the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism -LRB- rs1801133 -RRB- in rheumatoid_arthritis .
26734634	0	MTHFR	57,62	methylenetetrahydrofolate_reductase	20,55	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism and carotid intima medial thickness progression in post ischaemic_stroke patient .
8673563	0	MTHFR	93,98	methylenetetrahydrofolate_reductase	56,91	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Distribution in healthy and coronary populations of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T mutation .
8940272	0	MTHFR	78,83	methylenetetrahydrofolate_reductase	41,76	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Severe and mild mutations in cis for the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene , and description of five novel mutations in MTHFR .
9409277	0	MTHFR	92,97	methylenetetrahydrofolate_reductase	36,71	MTHFR	methylenetetrahydrofolate reductase	4524	4524	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Hyperhomocyst -LRB- e -RRB- inemia and a common methylenetetrahydrofolate_reductase mutation -LRB- Ala223Val MTHFR -RRB- in patients with inherited thrombophilic_coagulation_defects .
23227498	0	MTHFR	43,48	methyltetrahydrofolate_reductase	9,41	MTHFR	methyltetrahydrofolate reductase	4524	4524	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Role of methyltetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphism in the development of ischemic_stroke in the dwellers of the Kyrgyz Republic -RSB- .
12932832	0	MTIF2	62,67	mitochondrial_translation_initiation_factor_2	10,55	MTIF2	mitochondrial translation initiation factor 2	4528	4528	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human mitochondrial_translation_initiation_factor_2 gene -LRB- MTIF2 -RRB- : transcriptional analysis and identification of a pseudogene .
20953064	0	MTL1	21,25	Khd1p	58,63	MTL1	Khd1p	852905(Tax:4932)	852248(Tax:4932)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast .
21490059	0	MTM-1	33,38	CED-5-CED-12	89,101	MTM-1	CED-5-CED-12	172148(Tax:6239)	177942;172890	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. _ elegans .
15998640	0	MTMR13	57,63	MTMR2	35,40	MTMR13	MTMR2	81846	8898	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13 , a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth_disease .
15998640	0	MTMR2	35,40	MTMR13	57,63	MTMR2	MTMR13	8898	81846	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13 , a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth_disease .
20410104	0	MTMR2	35,40	PSD-95	56,62	MTMR2	PSD-95	8898	1742	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic .
11335693	0	MTMR2	66,71	myotubularin-related_protein_2	34,64	MTMR2	myotubularin-related protein 2	8898	8898	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the 5 ' region of the myotubularin-related_protein_2 -LRB- MTMR2 -RRB- gene in autosomal_recessive_hereditary_neuropathy with focally folded myelin .
26787466	0	MTMR3	24,29	mTORC1	45,51	MTMR3	mTORC1	8897	382056(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity .
19125695	0	MTMR4	25,30	Nedd4	73,78	MTMR4	Nedd4	9110	4734	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4 .
18396045	0	MTND5	27,32	ND5	22,25	MTND5	ND5	4540	4540	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A novel mitochondrial ND5 -LRB- MTND5 -RRB- gene mutation giving isolated exercise intolerance .
22809454	0	MTNR1A	47,53	Melatonin_Receptor_1A	24,45	MTNR1A	Melatonin Receptor 1A	443022(Tax:9940)	443022(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterisation of the Melatonin_Receptor_1A -LRB- MTNR1A -RRB- gene in the Rasa Aragonesa sheep breed : association with reproductive seasonality .
20726823	0	MTNR1A	64,70	melatonin_receptor	44,62	MTNR1A	melatonin receptor	4543	4543	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Analysis of genetic variations in the human melatonin_receptor -LRB- MTNR1A , MTNR1B -RRB- genes and antipsychotics-induced tardive_dyskinesia in schizophrenia .
21211471	0	MTNR1A	45,51	melatonin_receptor_1A	22,43	MTNR1A	melatonin receptor 1A	443022(Tax:9940)	443022(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism at the melatonin_receptor_1A -LRB- MTNR1A -RRB- gene in Sarda ewes affects fertility after AI in the spring .
21497385	0	MTNR1A	79,85	melatonin_receptor_1A	56,77	MTNR1A	melatonin receptor 1A	539948(Tax:9913)	539948(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the Mediterranean Italian buffaloes melatonin_receptor_1A -LRB- MTNR1A -RRB- gene and its association with reproductive seasonality .
21652546	0	MTNR1A	27,33	melatonin_receptor_1A	4,25	MTNR1A	melatonin receptor 1A	4543	4543	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The melatonin_receptor_1A -LRB- MTNR1A -RRB- gene is associated with recurrent and idiopathic calcium nephrolithiasis .
22935159	0	MTNR1A	43,49	melatonin_receptor_1A	20,41	MTNR1A	melatonin receptor 1A	4543	4543	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between melatonin_receptor_1A -LRB- MTNR1A -RRB- gene polymorphism and the reproductive performance of Mediterranean Italian buffaloes .
24595444	0	MTNR1A	43,49	melatonin_receptor_1A	20,41	MTNR1A	melatonin receptor 1A	4543	4543	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between melatonin_receptor_1A -LRB- MTNR1A -RRB- gene single-nucleotide polymorphisms and the velvet antler yield of Sika deer .
27038909	0	MTNR1A	46,52	melatonin_receptor_1A	23,44	MTNR1A	melatonin receptor 1A	4543	4543	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	DNA methylation within melatonin_receptor_1A -LRB- MTNR1A -RRB- mediates paternally transmitted genetic variant effect on asthma_plus_rhinitis .
26431121	0	MTNR1B	72,78	Melatonin_Receptor_1B	49,70	MTNR1B	Melatonin Receptor 1B	4544	4544	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	The Association of rs4753426 Polymorphism in the Melatonin_Receptor_1B -LRB- MTNR1B -RRB- Gene and Susceptibility to Adolescent_Idiopathic_Scoliosis : A Systematic Review and Meta-analysis .
17632395	0	MTNR1B	23,29	Melatonin_receptor_1B	0,21	MTNR1B	Melatonin receptor 1B	4544	4544	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Melatonin_receptor_1B -LRB- MTNR1B -RRB- gene polymorphism is associated with the occurrence of adolescent_idiopathic_scoliosis .
17108395	0	MTNR1B	40,46	melatonin_receptor_1B	12,33	MTNR1B	melatonin receptor 1B	4544	4544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of melatonin_receptor_1B gene -LRB- MTNR1B -RRB- in adolescent idiopathic scoliosis -- a genetic association study .
19455304	0	MTNR1B	60,66	melatonin_receptor_1B	32,53	MTNR1B	melatonin receptor 1B	4544	4544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variation in the melatonin_receptor_1B gene -LRB- MTNR1B -RRB- is associated with decreased early-phase insulin response .
25898821	0	MTNR1B	49,55	melatonin_receptor_1B	21,42	MTNR1B	melatonin receptor 1B	4544	4544	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The polymorphisms of melatonin_receptor_1B gene -LRB- MTNR1B -RRB- -LRB- rs4753426 and rs10830963 -RRB- and susceptibility to adolescent_idiopathic_scoliosis : a meta-analysis .
26043155	0	MTOR	56,60	CD4	29,32	MTOR	CD4	2475	920	Gene	Gene	restricting|dobj|START_ENTITY promotes|advcl|restricting promotes|dobj|survival survival|nmod|cells cells|compound|END_ENTITY	TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy .
25692619	0	MTOR	58,62	PTEN	115,119	MTOR	PTEN	2475	5728	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|medullary_carcinoma medullary_carcinoma|nmod|loss loss|nmod|expression expression|compound|END_ENTITY	Therapeutic approach guided by genetic alteration : use of MTOR inhibitor in renal medullary_carcinoma with loss of PTEN expression .
21907263	0	MTOR	43,47	mammalian_target_of_rapamycin	12,41	MTOR	mammalian target of rapamycin	2475	2475	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Mechanistic mammalian_target_of_rapamycin -LRB- MTOR -RRB- cell signaling : effects of select nutrients and secreted_phosphoprotein_1 on development of mammalian conceptuses .
24009738	0	MTOR	46,50	phospholipase_D	12,27	MTOR	phospholipase D	2475	2822	Gene	Gene	modulating|dobj|START_ENTITY END_ENTITY|advcl|modulating	The role of phospholipase_D in modulating the MTOR signaling pathway in polycystic_kidney_disease .
21684740	0	MTP	55,58	microsomal_triglyceride_transfer_protein	13,53	MTP	microsomal triglyceride transfer protein	4547	4547	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of microsomal_triglyceride_transfer_protein -LRB- MTP -RRB- inhibitors with potential for decreased active metabolite load compared to dirlotapide .
9831631	0	MTP	101,104	microsomal_triglyceride_transfer_protein	59,99	MTP	microsomal triglyceride transfer protein	4547	4547	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of two polymorphisms in the promoter of the microsomal_triglyceride_transfer_protein -LRB- MTP -RRB- gene : lack of association with lipoprotein profiles .
12161425	0	MTP1	51,55	Slc11a3	57,64	MTP1	Slc11a3	53945(Tax:10090)	53945(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of reticuloendothelial iron transporter MTP1 -LRB- Slc11a3 -RRB- by inflammation .
21667249	0	MTPN	92,96	Myotrophin	80,90	MTPN	Myotrophin	100521697	100521697	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization , expression patterns and subcellular localization of Myotrophin -LRB- MTPN -RRB- gene in porcine skeletal muscle .
12325027	0	MTRNR1	95,101	mitochondrial_12S_RNA	72,93	MTRNR1	mitochondrial 12S RNA	4549	4549	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Pyrosequencing for detection of mutations in the connexin_26 -LRB- GJB2 -RRB- and mitochondrial_12S_RNA -LRB- MTRNR1 -RRB- genes associated with hereditary_hearing_loss .
20373852	0	MTRR	84,88	CYP1A1	30,36	MTRR	CYP1A1	4552	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTRR	84,88	CYP2C19	46,53	MTRR	CYP2C19	4552	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTRR	84,88	CYP2C9	38,44	MTRR	CYP2C9	4552	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTRR	84,88	CYP2D6	55,61	MTRR	CYP2D6	4552	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTRR	84,88	GSTM1	70,75	MTRR	GSTM1	4552	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTRR	84,88	GSTT1	63,68	MTRR	GSTT1	4552	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
11807892	0	MTRR	104,108	MTHFR	162,167	MTRR	MTHFR	4552	4524	Gene	Gene	methylenetetrahydrofolate_reductase|appos|START_ENTITY polymorphisms|nmod|methylenetetrahydrofolate_reductase polymorphisms|dep|report report|nmod|site site|amod|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- in ethnic populations in Texas ; a report of a novel MTHFR polymorphic site , G1793A .
11807892	0	MTRR	104,108	MTHFR	62,67	MTRR	MTHFR	4552	4524	Gene	Gene	methylenetetrahydrofolate_reductase|appos|START_ENTITY methylenetetrahydrofolate_reductase|appos|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- in ethnic populations in Texas ; a report of a novel MTHFR polymorphic site , G1793A .
12810988	0	MTRR	26,30	MTHFR	14,19	MTRR	MTHFR	4552	4524	Gene	Gene	genes|amod|START_ENTITY -RSB-|nsubj|genes -RSB-|nsubj|Mutations Mutations|nmod|END_ENTITY	-LSB- Mutations of MTHFR , MTR , MTRR genes as high risk factors for neural tube defects -RSB- .
19035314	0	MTRR	79,83	MTHFR	37,42	MTRR	MTHFR	4552	4524	Gene	Gene	Methylenetetrahydrofolate_reductase|dep|START_ENTITY Methylenetetrahydrofolate_reductase|dep|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- gene polymorphisms as risk factors for hepatocellular_carcinoma in a Korean population .
20373852	0	MTRR	84,88	MTHFR	77,82	MTRR	MTHFR	4552	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
21438757	0	MTRR	27,31	MTHFR	15,20	MTRR	MTHFR	4552	4524	Gene	Gene	RFC1|appos|START_ENTITY RFC1|compound|END_ENTITY	Association of MTHFR , MTR , MTRR , RFC1 , and DHFR gene polymorphisms with susceptibility to sporadic colon_cancer .
25322900	0	MTRR	121,125	MTHFR	79,84	MTRR	MTHFR	4552	4524	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|amod|methylenetetrahydrofolate_reductase methylenetetrahydrofolate_reductase|dep|END_ENTITY	Riboflavin status modifies the effects of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- and methionine_synthase_reductase -LRB- MTRR -RRB- polymorphisms on homocysteine .
25634728	0	MTRR	151,155	MTHFR	112,117	MTRR	MTHFR	4552	4524	Gene	Gene	Methionine_Synthase_Reductase|appos|START_ENTITY Complications|nsubj|Methionine_Synthase_Reductase Complications|ccomp|Supplementation Supplementation|dep|END_ENTITY	Individualized Supplementation of Folic Acid According to Polymorphisms of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- , Methionine_Synthase_Reductase -LRB- MTRR -RRB- Reduced Pregnant Complications .
20373852	0	MTRR	84,88	NAT2	96,100	MTRR	NAT2	4552	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	MTRR	84,88	NQO1	90,94	MTRR	NQO1	4552	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
18515090	0	MTRR	61,65	methionine_synthase_reductase	30,59	MTRR	methionine synthase reductase	4552	4552	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	His595Tyr polymorphism in the methionine_synthase_reductase -LRB- MTRR -RRB- gene is associated with pancreatic_cancer risk .
9222307	0	MTS-1	35,40	p16	30,33	MTS-1	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Infrequent alterations of the p16 -LRB- MTS-1 -RRB- gene in human gastric_cancer .
7834619	0	MTS1	27,31	MTS2	42,46	MTS1	MTS2	1029	1030	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	In vivo occurrence of p16 -LRB- MTS1 -RRB- and p15 -LRB- MTS2 -RRB- alterations preferentially in non-small cell lung_cancers .
9066685	0	MTS1	16,20	NM23	10,14	MTS1	NM23	6298	4830	Gene	Gene	ratio|nummod|START_ENTITY END_ENTITY|dep|ratio	Increased NM23 : MTS1 ratio inversely correlated with metastasis behaviour in human lung_squamous_cell_carcinoma .
9120722	0	MTS1	20,24	P16	15,18	MTS1	P16	1029	1029	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of P16 -LRB- MTS1 -RRB- in node-positive non-small_cell_lung_carcinomas .
18619032	0	MTS1	22,26	S100A4	28,34	MTS1	S100A4	6275	6275	Gene	Gene	Functions|nmod|START_ENTITY Functions|appos|END_ENTITY	-LSB- Functions of protein MTS1 -LRB- S100A4 -RRB- in normal and tumor cells -RSB- .
7563391	0	MTS1	24,28	p16	19,22	MTS1	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alterations of the p16 -LRB- MTS1 -RRB- gene in testicular , ovarian , and endometrial_malignancies .
7726912	0	MTS1	64,68	p16	59,62	MTS1	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequent somatic mutations and homozygous deletions of the p16 -LRB- MTS1 -RRB- gene in pancreatic_adenocarcinoma .
9212218	0	MTS1	48,52	p16	43,46	MTS1	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Loss of heterozygosity on chromosome 9 and p16 -LRB- MTS1 , CDKN2 -RRB- gene mutations in esophageal_cancers .
9531999	0	MTS1	62,66	p16	58,61	MTS1	p16	1029	1029	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Expression of cyclin_D1 , retinoblastoma gene protein , and p16 MTS1 protein in atypical_adenomatous_hyperplasia and adenocarcinoma_of_the_lung .
8973369	0	MTS1	68,72	p16INK4a	58,66	MTS1	p16INK4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 5 ' - flanking region of the E1 alpha form of the murine p16INK4a -LRB- MTS1 -RRB- gene .
7834619	0	MTS2	42,46	MTS1	27,31	MTS2	MTS1	1030	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	In vivo occurrence of p16 -LRB- MTS1 -RRB- and p15 -LRB- MTS2 -RRB- alterations preferentially in non-small cell lung_cancers .
7675459	0	MTS2	66,70	P15	61,64	MTS2	P15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure , expression and mutational analysis of the P15 -LRB- MTS2 -RRB- gene .
8419181	0	MTSP-1	40,46	granzyme_A	28,38	MTSP-1	granzyme A	19143(Tax:10090)	14938(Tax:10090)	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Charge-dependent binding of granzyme_A -LRB- MTSP-1 -RRB- to basement membranes .
1976012	0	MTSP-1	59,65	mouse_T_cell_associated_serine_proteinase-1	14,57	MTSP-1	mouse T cell associated serine proteinase-1	19143(Tax:10090)	19143(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of mouse_T_cell_associated_serine_proteinase-1 -LRB- MTSP-1 -RRB- by proteinase inhibitors and sulfated polysaccharides .
21909138	0	MTSS1	0,5	DNA_methyltransferase_3B	25,49	MTSS1	DNA methyltransferase 3B	9788	1789	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	MTSS1 , a novel target of DNA_methyltransferase_3B , functions as a tumor suppressor in hepatocellular_carcinoma .
24318128	0	MTSS1	19,24	b-TRCP	4,10	MTSS1	b-TRCP	9788	8945	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	SCF b-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration .
25783158	0	MTSS1	81,86	miR-15b	65,72	MTSS1	miR-15b	9788	406949	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	EGF induces microRNAs that target suppressors of cell migration : miR-15b targets MTSS1 in breast_cancer .
17854051	0	MTTP	90,94	microsomal_triglyceride_transfer_protein	48,88	MTTP	microsomal triglyceride transfer protein	4547	4547	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional analysis of promoter variants in the microsomal_triglyceride_transfer_protein -LRB- MTTP -RRB- gene .
18697801	0	MTTP	109,113	microsomal_triglyceride_transfer_protein	67,107	MTTP	microsomal triglyceride transfer protein	4547	4547	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hepatocyte nuclear factor 1 binding element within the promoter of microsomal_triglyceride_transfer_protein -LRB- MTTP -RRB- gene is crucial for MTTP basal expression and insulin responsiveness .
11231300	0	MTf	86,89	membrane-bound_transferrin-like_protein	45,84	MTf	membrane-bound transferrin-like protein	30060(Tax:10090)	30060(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and promoter analysis of the mouse membrane-bound_transferrin-like_protein -LRB- MTf -RRB- gene .
10811121	0	MUC-1	134,139	MUC-1	59,64	MUC-1	MUC-1	4582	17829(Tax:10090)	Gene	Gene	express|nmod|START_ENTITY express|dobj|END_ENTITY	Immunity to murine breast_cancer cells modified to express MUC-1 , a human breast_cancer antigen , in transgenic_mice tolerant to human MUC-1 .
10811121	0	MUC-1	59,64	MUC-1	134,139	MUC-1	MUC-1	17829(Tax:10090)	4582	Gene	Gene	express|dobj|START_ENTITY express|nmod|END_ENTITY	Immunity to murine breast_cancer cells modified to express MUC-1 , a human breast_cancer antigen , in transgenic_mice tolerant to human MUC-1 .
8443822	0	MUC-1	93,98	Mucin	0,5	MUC-1	Mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY express|dobj|gene synthesis|acl:relcl|express synthesis|compound|END_ENTITY	Mucin synthesis and secretion in various human epithelial_cancer cell lines that express the MUC-1 mucin gene .
10738572	0	MUC-1	21,26	mucin	14,19	MUC-1	mucin	4582	100508689	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of mucin -LRB- MUC-1 -RRB- from a mini-Epstein-Barr_virus in immortalized B-cells to generate tumor antigen specific cytotoxic T cells .
7686886	0	MUC-1	101,106	mucin	118,123	MUC-1	mucin	4582	100508689	Gene	Gene	epithelial|amod|START_ENTITY core|amod|epithelial core|compound|END_ENTITY	Development of an anti-idiotypic antibody reactive with an antibody defining the epitope RPAP in the MUC-1 epithelial mucin core .
8443822	0	MUC-1	93,98	mucin	99,104	MUC-1	mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Mucin synthesis and secretion in various human epithelial_cancer cell lines that express the MUC-1 mucin gene .
8643693	0	MUC-1	106,111	mucin	80,85	MUC-1	mucin	4582	100508689	Gene	Gene	cDNA-transfected|amod|START_ENTITY cells|amod|cDNA-transfected END_ENTITY|nmod|cells	Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr_virus-immortalized autologous B cells .
8706053	0	MUC-1	33,38	mucin	40,45	MUC-1	mucin	4582	100508689	Gene	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	Pre-immunotherapy serum CA27 .29 -LRB- MUC-1 -RRB- mucin level and CD69 + lymphocytes correlate with effects of Theratope sialyl-Tn-KLH cancer vaccine in active specific immunotherapy .
9101416	0	MUC-1	59,64	mucin	66,71	MUC-1	mucin	4582	100508689	Gene	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	Prognostic significance of preimmunotherapy serum CA27 .29 -LRB- MUC-1 -RRB- mucin level after active specific immunotherapy of metastatic adenocarcinoma patients .
9212228	0	MUC-1	14,19	mucin	20,25	MUC-1	mucin	4582	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Comparison of MUC-1 mucin expression in epithelial and non-epithelial cancer cell lines and demonstration of a new short variant form -LRB- MUC-1 / Z -RRB- .
9346852	0	MUC-1	35,40	mucin	108,113	MUC-1	mucin	4582	100508689	Gene	Gene	mucin|appos|START_ENTITY expressed|nsubj|mucin resembles|dep|expressed resembles|nsubj|END_ENTITY	Recombinant epithelial cell mucin -LRB- MUC-1 -RRB- expressed in baculovirus resembles antigenically tumor associated mucin , target for cancer immunotherapy .
17484881	0	MUC-2	37,42	Matrix_metalloproteinase-9	0,26	MUC-2	Matrix metalloproteinase-9	17831(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Matrix_metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation .
12471471	0	MUC-2	23,28	mucin	29,34	MUC-2	mucin	4583	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model .
12632359	0	MUC-2	0,5	mucin	6,11	MUC-2	mucin	4583	100508689	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	MUC-2 mucin production in Hirschsprung 's _ disease : possible association with enterocolitis development .
1477935	0	MUC-2	53,58	mucin	30,35	MUC-2	mucin	4583	100508689	Gene	Gene	polypeptide|xcomp|START_ENTITY polypeptide|nsubj|localization localization|nmod|core core|compound|END_ENTITY	-LSB- Histological localization of mucin core polypeptide MUC-2 in application to the differential diagnosis of adenocarcinoma -RSB- .
12441351	0	MUC1	63,67	ADAM_17	46,53	MUC1	ADAM 17	4582	6868	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha_converting_enzyme / ADAM_17 mediates MUC1 shedding .
12372344	0	MUC1	64,68	CD227	70,75	MUC1	CD227	4582	4582	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive and inducible expression of the epithelial antigen MUC1 -LRB- CD227 -RRB- in human T cells .
18609108	0	MUC1	63,67	CEA	50,53	MUC1	CEA	4582	1084	Gene	Gene	intervals|appos|START_ENTITY intervals|nmod|carcinoembryonic_antigen carcinoembryonic_antigen|appos|END_ENTITY	Reference intervals for carcinoembryonic_antigen -LRB- CEA -RRB- , CA125 , MUC1 , Alfa-foeto-protein -LRB- AFP -RRB- , neuron-specific_enolase -LRB- NSE -RRB- and CA19 .9 from the NORIP study .
22457794	0	MUC1	0,4	EGFR	101,105	MUC1	EGFR	4582	1956	Gene	Gene	contributes|nsubj|START_ENTITY contributes|advcl|facilitating facilitating|dobj|activation activation|amod|END_ENTITY	MUC1 contributes to BPDE-induced human bronchial epithelial cell transformation through facilitating EGFR activation .
23686469	0	MUC1	26,30	EGFR	10,14	MUC1	EGFR	4582	1956	Gene	Gene	expression|nummod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Activated EGFR stimulates MUC1 expression in human uterine and pancreatic_cancer cell lines .
26645913	0	MUC1	92,96	EGFR	122,126	MUC1	EGFR	4582	1956	Gene	Gene	tail|compound|START_ENTITY association|nmod|tail phosphorylation|nmod|association stimulates|dobj|phosphorylation stimulates|nmod|activation activation|amod|END_ENTITY	Pseudomonas_aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation .
27092881	0	MUC1	0,4	EGFR	16,20	MUC1	EGFR	4582	1956	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	MUC1 stimulates EGFR expression and function in endometrial_cancer .
9930070	0	MUC1	0,4	EGFR	76,80	MUC1	EGFR	4582	1956	Gene	Gene	expression|compound|START_ENTITY independent|nsubj|expression independent|nmod|expression expression|compound|END_ENTITY	MUC1 -LRB- episialin -RRB- expression in non-small_cell_lung_cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients .
16874487	0	MUC1	78,82	HLA-A	56,61	MUC1	HLA-A	4582	3105	Gene	Gene	epitope|compound|START_ENTITY epitope|amod|END_ENTITY	The cytotoxic T cell response to peptide analogs of the HLA-A * 0201-restricted MUC1 signal sequence epitope , M1 .2 .
12924525	0	MUC1	14,18	KL-6	0,4	MUC1	KL-6	4582	4582	Gene	Gene	mucin|compound|START_ENTITY END_ENTITY|appos|mucin	KL-6 , a human MUC1 mucin , is expressed early in premature lung .
16289035	0	MUC1	14,18	KL-6	0,4	MUC1	KL-6	4582	4582	Gene	Gene	mucin|compound|START_ENTITY END_ENTITY|appos|mucin	KL-6 , a human MUC1 mucin , promotes proliferation and survival of lung fibroblasts .
21466814	0	MUC1	19,23	KL-6	14,18	MUC1	KL-6	4582	4582	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of KL-6 / MUC1 in pancreatic_ductal_carcinoma and its potential relationship with b-catenin in tumor progression .
21617869	0	MUC1	19,23	KL-6	14,18	MUC1	KL-6	4582	4582	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of KL-6 / MUC1 in pancreatic_cancer tissues and its potential involvement in tumor metastasis .
9330247	0	MUC1	125,129	KL-6	111,115	MUC1	KL-6	4582	4582	Gene	Gene	mucin|compound|START_ENTITY END_ENTITY|appos|mucin	Detection of interstitial_pneumonitis in patients with rheumatoid_arthritis by measuring circulating levels of KL-6 , a human MUC1 mucin .
9376125	0	MUC1	14,18	KL-6	0,4	MUC1	KL-6	4582	4582	Gene	Gene	mucin|compound|START_ENTITY END_ENTITY|appos|mucin	KL-6 , a human MUC1 mucin , is chemotactic for human fibroblasts .
8422670	0	MUC1	215,219	MUC1	95,99	MUC1	MUC1	4582	4582	Gene	Gene	gene|compound|START_ENTITY transfected|nmod|gene related|parataxis|transfected related|nmod|sequence sequence|acl|encoded encoded|nmod|gene gene|compound|END_ENTITY	Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene : effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene .
8422670	0	MUC1	95,99	MUC1	215,219	MUC1	MUC1	4582	4582	Gene	Gene	gene|compound|START_ENTITY encoded|nmod|gene sequence|acl|encoded related|nmod|sequence related|parataxis|transfected transfected|nmod|gene gene|compound|END_ENTITY	Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene : effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene .
8912645	0	MUC1	44,48	MUC1/SEC	24,32	MUC1	MUC1/SEC	4582	4582	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Detection of a secreted MUC1/SEC protein by MUC1 isoform specific monoclonal antibodies .
11889602	0	MUC1	7,11	MUC2	13,17	MUC1	MUC2	4582	4583	Gene	Gene	Mucins|nummod|START_ENTITY Mucins|nummod|END_ENTITY	Mucins MUC1 , MUC2 , MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric_carcinoma .
11889602	0	MUC1	7,11	MUC5AC	19,25	MUC1	MUC5AC	4582	4586	Gene	Gene	Mucins|nummod|START_ENTITY Mucins|nummod|END_ENTITY	Mucins MUC1 , MUC2 , MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric_carcinoma .
11724326	0	MUC1	12,16	Mucin	0,5	MUC1	Mucin	4582	100508689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mucin gene -LRB- MUC1 -RRB- transfer into human dendritic cells by cationic liposomes and recombinant adenovirus .
12439613	0	MUC1	12,16	Mucin	0,5	MUC1	Mucin	4582	100508689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mucin gene -LRB- MUC1 -RRB- transfected dendritic cells as vaccine : results of a phase I/II clinical trial .
15280401	0	MUC1	80,84	Mucin	0,5	MUC1	Mucin	4582	100508689	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Mucin expression in pleomorphic_adenoma of salivary gland : a potential role for MUC1 as a marker to predict recurrence .
26393683	0	MUC1	18,22	Mucin	23,28	MUC1	Mucin	4582	100508689	Gene	Gene	Counter-Regulates|compound|START_ENTITY Counter-Regulates|compound|END_ENTITY	Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages .
9685530	0	MUC1	23,27	Mucin	0,5	MUC1	Mucin	4582	100508689	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Mucin gene expression -LRB- MUC1 , MUC2 , and MUC5/5AC -RRB- in nasal epithelial cells of cystic_fibrosis , allergic_rhinitis , and normal individuals .
23505541	0	MUC1	0,4	NM23-H1	14,21	MUC1	NM23-H1	4582	4830	Gene	Gene	ligand|compound|START_ENTITY ligand|appos|END_ENTITY	MUC1 * ligand , NM23-H1 , is a novel growth factor that maintains human stem cells in a more na ve state .
22266848	0	MUC1	0,4	PDGFA	15,20	MUC1	PDGFA	4582	5154	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MUC1 regulates PDGFA expression during pancreatic_cancer progression .
17586693	0	MUC1	42,46	Phosphoinositide_3-kinase	0,25	MUC1	Phosphoinositide 3-kinase	4582	5295	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Phosphoinositide_3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like_receptor_5 signaling .
21637370	0	MUC1	23,27	SP-D	52,56	MUC1	SP-D	4582	6441	Gene	Gene	Independent|compound|START_ENTITY Independent|nmod|END_ENTITY	A Normal Range of KL-6 / MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography .
19578748	0	MUC1	0,4	STAT3	31,36	MUC1	STAT3	4582	6774	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MUC1 is a downstream target of STAT3 and regulates lung_cancer cell survival and invasion .
25327561	0	MUC1	81,85	STAT3	23,28	MUC1	STAT3	4582	6774	Gene	Gene	expression|compound|START_ENTITY upregulation|nmod|expression resistance|nmod|upregulation mediates|dobj|resistance mediates|nsubj|activation activation|nmod|END_ENTITY	Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression .
20448050	0	MUC1	28,32	TNF-a	0,5	MUC1	TNF-a	17829(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	TNF-a is a key regulator of MUC1 , an anti-inflammatory molecule , during airway Pseudomonas_aeruginosa_infection .
17575006	0	MUC1	18,22	TNF-alpha	0,9	MUC1	TNF-alpha	4582	7124	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	TNF-alpha induces MUC1 gene transcription in lung epithelial cells : its signaling pathway and biological implication .
15142990	0	MUC1	39,43	Tumor_necrosis_factor_alpha	0,27	MUC1	Tumor necrosis factor alpha	4582	7124	Gene	Gene	synthesis|compound|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line .
15020226	0	MUC1	0,4	adenomatous_polyposis_coli	23,49	MUC1	adenomatous polyposis coli	4582	324	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	MUC1 can interact with adenomatous_polyposis_coli in breast_cancer .
24979278	0	MUC1	0,4	cyclin_D1	15,24	MUC1	cyclin D1	4582	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MUC1 regulates cyclin_D1 gene expression through p120_catenin and b-catenin .
11278868	0	MUC1	11,15	epidermal_growth_factor_receptor	31,63	MUC1	epidermal growth factor receptor	4582	1956	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transgenic MUC1 interacts with epidermal_growth_factor_receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland .
16082192	0	MUC1	15,19	epidermal_growth_factor_receptor	62,94	MUC1	epidermal growth factor receptor	4582	1956	Gene	Gene	synthesis|compound|START_ENTITY Suppression|nmod|synthesis downregulates|nsubj|Suppression downregulates|dobj|expression expression|nmod|END_ENTITY	Suppression of MUC1 synthesis downregulates expression of the epidermal_growth_factor_receptor .
20406885	0	MUC1	0,4	epidermal_growth_factor_receptor	56,88	MUC1	epidermal growth factor receptor	17829(Tax:10090)	13649(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	MUC1 regulates nuclear localization and function of the epidermal_growth_factor_receptor .
22250084	0	MUC1	18,22	epidermal_growth_factor_receptor	50,82	MUC1	epidermal growth factor receptor	4582	1956	Gene	Gene	mucin|compound|START_ENTITY phosphorylated|nsubjpass|mucin phosphorylated|nmod|END_ENTITY	Membrane-tethered MUC1 mucin is phosphorylated by epidermal_growth_factor_receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88 .
9930070	0	MUC1	0,4	episialin	6,15	MUC1	episialin	4582	4582	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MUC1 -LRB- episialin -RRB- expression in non-small_cell_lung_cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients .
17083744	0	MUC1	88,92	estrogen_receptor_alpha	114,137	MUC1	estrogen receptor alpha	4582	2099	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	MUC1 gene overexpressed in breast_cancer : structure and transcriptional activity of the MUC1 promoter and role of estrogen_receptor_alpha -LRB- ERalpha -RRB- in regulation of the MUC1 gene expression .
19102213	0	MUC1	128,132	hTERT	169,174	MUC1	hTERT	4582	7015	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The preparation of myeloma-specific T cells activated with dendritic cells loaded with nonapeptides derived from mucin protein MUC1 and catalytic subunit of telomerase hTERT -RSB- .
12210742	0	MUC1	27,31	interferon-gamma	97,113	MUC1	interferon-gamma	4582	3458	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression stimulation|nmod|END_ENTITY	Synergistic stimulation of MUC1 expression in normal breast epithelia and breast_cancer cells by interferon-gamma and tumor_necrosis_factor-alpha .
7842630	0	MUC1	44,48	interferon-gamma	10,26	MUC1	interferon-gamma	4582	3458	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian_carcinoma cell lines .
19201396	0	MUC1	46,50	interleukin-6	19,32	MUC1	interleukin-6	4582	3569	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Macrophage-derived interleukin-6 up-regulates MUC1 , but down-regulates MUC2 expression in the human colon_cancer HT-29 cell line .
21339746	0	MUC1	0,4	matrix_metalloproteinase_13	78,105	MUC1	matrix metalloproteinase 13	4582	4322	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	MUC1 induces metastasis in esophageal_squamous_cell_carcinoma by upregulating matrix_metalloproteinase_13 .
10398137	0	MUC1	14,18	mucin	28,33	MUC1	mucin	4582	100508689	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall_bladder_carcinoma : an immunohistochemical and in situ hybridization study .
10459625	0	MUC1	42,46	mucin	23,28	MUC1	mucin	4582	100508689	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|protein protein|amod|END_ENTITY	Frequent expression of mucin core protein MUC1 in non-neoplastic_gallbladder mucosa from patients with pancreaticobiliary maljunction .
10583575	0	MUC1	14,18	mucin	28,33	MUC1	mucin	4582	100508689	Gene	Gene	products|compound|START_ENTITY products|compound|END_ENTITY	Expression of MUC1 and MUC2 mucin gene products in Barrett 's _ metaplasia , dysplasia and adenocarcinoma : an immunopathological study with clinical correlation .
10936782	0	MUC1	27,31	mucin	32,37	MUC1	mucin	4582	100508689	Gene	Gene	Detection|nmod|START_ENTITY END_ENTITY|nsubj|Detection	Detection and isolation of MUC1 mucin from larynx_squamous_cell_carcinoma .
11009623	0	MUC1	78,82	mucin	71,76	MUC1	mucin	4582	4582	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Structural effects of O-glycosylation on a 15-residue peptide from the mucin -LRB- MUC1 -RRB- core protein .
11173916	0	MUC1	0,4	mucin	5,10	MUC1	mucin	4582	100508689	Gene	Gene	protein|nummod|START_ENTITY protein|amod|END_ENTITY	MUC1 mucin core protein binds to the domain 1 of ICAM-1 .
12000758	0	MUC1	12,16	mucin	113,118	MUC1	mucin	4582	100508689	Gene	Gene	probe|compound|START_ENTITY reflects|nsubj|probe reflects|dobj|profiles profiles|nmod|END_ENTITY	Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast_cancer mucin .
12529261	0	MUC1	6,10	mucin	41,46	MUC1	mucin	17829(Tax:10090)	100508689	Gene	Gene	variants|compound|START_ENTITY contribute|nsubj|variants contribute|xcomp|END_ENTITY	Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice .
12578901	0	MUC1	14,18	mucin	28,33	MUC1	mucin	4582	100508689	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of MUC1 and MUC2 mucin gene products in human ovarian_carcinomas .
1289420	0	MUC1	24,28	mucin	29,34	MUC1	mucin	4582	100508689	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Expression of the human MUC1 mucin cDNA in a hamster pancreatic_tumor cell line HP-1 .
12925576	0	MUC1	30,34	mucin	117,122	MUC1	mucin	4582	100508689	Gene	Gene	glycopeptides|nummod|START_ENTITY studies|nmod|glycopeptides studies|dep|implication implication|nmod|O-glycosylation O-glycosylation|nmod|core core|compound|END_ENTITY	Conformational studies on the MUC1 tandem repeat glycopeptides : implication for the enzymatic O-glycosylation of the mucin protein core .
15944787	0	MUC1	20,24	mucin	25,30	MUC1	mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphism of the MUC1 mucin gene is associated with susceptibility to lung_adenocarcinoma and poor prognosis .
17213039	0	MUC1	61,65	mucin	41,46	MUC1	mucin	4582	100508689	Gene	Gene	cores|nummod|START_ENTITY peptide|dobj|cores peptide|nsubj|Relationship Relationship|nmod|immunoexpression immunoexpression|nmod|END_ENTITY	Relationship between immunoexpression of mucin peptide cores MUC1 and MUC2 and Lauren 's histologic subtypes of gastric_carcinomas .
18154934	0	MUC1	14,18	mucin	19,24	MUC1	mucin	4582	100508689	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Activation of MUC1 mucin expression by bile_acids in human esophageal_adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase .
19631667	0	MUC1	34,38	mucin	19,24	MUC1	mucin	4582	100508689	Gene	Gene	mucin|compound|START_ENTITY END_ENTITY|appos|mucin	Expression of KL-6 mucin , a human MUC1 mucin , in intrahepatic_cholangiocarcinoma and its potential involvement in tumor cell adhesion and invasion .
20598042	0	MUC1	30,34	mucin	14,19	MUC1	mucin	4582	100508689	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|antigens antigens|compound|END_ENTITY	Expression of mucin antigens -LRB- MUC1 and MUC16 -RRB- as a prognostic factor for mucinous_adenocarcinoma_of_the_uterine_cervix .
21071348	0	MUC1	14,18	mucin	19,24	MUC1	mucin	4582	100508689	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of MUC1 mucin in human umbilical vein endothelial cells -LRB- HUVEC -RRB- .
23566254	0	MUC1	20,24	mucin	14,19	MUC1	mucin	4582	100508689	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Transmembrane mucin MUC1 overexpression and its association with CD10 myeloid cells , transforming_growth_factor-b1 expression , and tumor budding grade in colorectal_cancer .
7588808	0	MUC1	48,52	mucin	53,58	MUC1	mucin	4582	100508689	Gene	Gene	glycosylation|nmod|START_ENTITY END_ENTITY|nsubj|glycosylation	Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast_cancer cells .
7591241	0	MUC1	60,64	mucin	76,81	MUC1	mucin	4582	100508689	Gene	Gene	secretion|nmod|START_ENTITY epithelial|nsubj|secretion epithelial|dobj|END_ENTITY	Heterogeneity in production , secretion and glycosylation of MUC1 epithelial mucin by primary cultures of ovarian_carcinoma .
7685318	0	MUC1	87,91	mucin	67,72	MUC1	mucin	4582	100508689	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Detection of a circulating antibody against a peptide epitope on a mucin core protein , MUC1 , in ulcerative_colitis .
7705823	0	MUC1	27,31	mucin	43,48	MUC1	mucin	4582	100508689	Gene	Gene	significance|nmod|START_ENTITY epithelial|nsubj|significance epithelial|dobj|expression expression|compound|END_ENTITY	Prognostic significance of MUC1 epithelial mucin expression in breast_cancer .
7842630	0	MUC1	44,48	mucin	49,54	MUC1	mucin	4582	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian_carcinoma cell lines .
7905449	0	MUC1	0,4	mucin	5,10	MUC1	mucin	4582	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MUC1 mucin expression as a marker of progression and metastasis of human colorectal_carcinoma .
8157358	0	MUC1	14,18	mucin	40,45	MUC1	mucin	4582	100508689	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of MUC1 , MUC2 , MUC3 and MUC4 mucin mRNAs in human pancreatic_and_intestinal_tumor cell lines .
8195140	0	MUC1	34,38	mucin	39,44	MUC1	mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the MUC1 mucin gene in colon_carcinoma cells by a soluble factor .
8308060	0	MUC1	49,53	mucin	37,42	MUC1	mucin	4582	100508689	Gene	Gene	MUC5|compound|START_ENTITY genes|dobj|MUC5 genes|nsubj|expression expression|nmod|END_ENTITY	Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations .
8422670	0	MUC1	215,219	mucin	100,105	MUC1	mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY transfected|nmod|gene related|parataxis|transfected related|nmod|sequence sequence|acl|encoded encoded|nmod|gene gene|compound|END_ENTITY	Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene : effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene .
8422670	0	MUC1	95,99	mucin	100,105	MUC1	mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene : effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene .
8638091	0	MUC1	16,20	mucin	59,64	MUC1	mucin	4582	4585	Gene	Gene	Membrane-bound|appos|START_ENTITY END_ENTITY|nsubj|Membrane-bound	Membrane-bound -LRB- MUC1 -RRB- and secretory -LRB- MUC2 , MUC3 , and MUC4 -RRB- mucin gene expression in human lung_cancer .
8813954	0	MUC1	16,20	mucin	30,35	MUC1	mucin	4582	100508689	Gene	Gene	Significance|nmod|START_ENTITY END_ENTITY|nsubj|Significance	Significance of MUC1 and MUC2 mucin expression in colorectal_cancer .
9349575	0	MUC1	0,4	mucin	5,10	MUC1	mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	MUC1 mucin gene , transcripts , and protein in adenomas and papillary_carcinomas of the thyroid .
9569234	0	MUC1	39,43	mucin	100,105	MUC1	mucin	4582	100508689	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|correlation correlation|nmod|expression expression|compound|END_ENTITY	Quantitative analysis of mRNA encoding MUC1 , MUC2 , and MUC5AC genes : a correlation between specific mucin gene expression and sialomucin expression in non-small cell lung_cancer .
9579577	0	MUC1	57,61	mucin	73,78	MUC1	mucin	4582	100508689	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Peritoneal fluid from ovarian_cancer patients stimulates MUC1 epithelial mucin expression in ovarian_cancer cell lines .
9583726	0	MUC1	73,77	mucin	53,58	MUC1	mucin	4582	100508689	Gene	Gene	cores|nummod|START_ENTITY peptide|dobj|cores peptide|nsubj|Correlation Correlation|nmod|reactivity reactivity|nmod|END_ENTITY	Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric_carcinomas .
9722669	0	MUC1	80,84	mucin	85,90	MUC1	mucin	4582	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Purification of nuclear proteins that potentially regulate transcription of the MUC1 mucin gene induced by a soluble factor .
9751614	0	MUC1	80,84	mucin	19,24	MUC1	mucin	4582	100508689	Gene	Gene	role|nmod|START_ENTITY implications|nmod|role Expression|dep|implications Expression|nmod|END_ENTITY	Expression of MUC1 mucin on activated human T cells : implications for a role of MUC1 in normal immune regulation .
9804253	0	MUC1	76,80	mucin	69,74	MUC1	mucin	4582	100508689	Gene	Gene	specialization|appos|START_ENTITY specialization|nmod|membrane-associated membrane-associated|appos|END_ENTITY	Regional specialization of the cell membrane-associated , polymorphic mucin -LRB- MUC1 -RRB- in human uterine epithelia .
10541345	0	MUC1	20,24	mucin-1	11,18	MUC1	mucin-1	4582	4582	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epithelial mucin-1 -LRB- MUC1 -RRB- expression and MA5 anti-MUC1 monoclonal antibody targeting in multiple myeloma .
17974963	0	MUC1	0,4	myelin-associated_glycoprotein	31,61	MUC1	myelin-associated glycoprotein	4582	4099	Gene	Gene	counter-receptor|nsubj|START_ENTITY counter-receptor|nmod|END_ENTITY	MUC1 is a counter-receptor for myelin-associated_glycoprotein -LRB- Siglec-4a -RRB- and their interaction contributes to adhesion in pancreatic_cancer perineural invasion .
24979278	0	MUC1	0,4	p120_catenin	49,61	MUC1	p120 catenin	4582	1500	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MUC1 regulates cyclin_D1 gene expression through p120_catenin and b-catenin .
1372533	0	MUC1	68,72	polymorphic_epithelial_mucin	38,66	MUC1	polymorphic epithelial mucin	4582	4582	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Tissue-specific expression of a human polymorphic_epithelial_mucin -LRB- MUC1 -RRB- in transgenic_mice .
8912645	0	MUC1/SEC	24,32	MUC1	44,48	MUC1/SEC	MUC1	4582	4582	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Detection of a secreted MUC1/SEC protein by MUC1 isoform specific monoclonal antibodies .
25277192	0	MUC13	21,26	MicroRNA-145	0,12	MUC13	MicroRNA-145	56667	406937	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic_cancer .
12898407	0	MUC13	48,53	mucin	78,83	MUC13	mucin	56667	100508689	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	-LSB- Normal human conjunctival epithelium expresses MUC13 , MUC15 , MUC16 and MUC17 mucin genes -RSB- .
17582096	0	MUC15	54,59	mucin	84,89	MUC15	mucin	337919(Tax:9913)	404104(Tax:9913)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of carbohydrate structures of bovine MUC15 and distribution of the mucin in bovine milk .
26918940	0	MUC16	51,56	CA125	58,63	MUC16	CA125	94025	94025	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Tumor_necrosis_factor-a and interferon-y stimulate MUC16 -LRB- CA125 -RRB- expression in breast , endometrial_and_ovarian_cancers through NFkB .
20497550	0	MUC16	47,52	Siglec-9	18,26	MUC16	Siglec-9	94025	27180	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	Identification of Siglec-9 as the receptor for MUC16 on human NK cells , B cells , and monocytes .
26918940	0	MUC16	51,56	Tumor_necrosis_factor-a	0,23	MUC16	Tumor necrosis factor-a	94025	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-a and interferon-y stimulate MUC16 -LRB- CA125 -RRB- expression in breast , endometrial_and_ovarian_cancers through NFkB .
10726166	0	MUC18	40,45	CD146	14,19	MUC18	CD146	4162	4162	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|molecules molecules|compound|END_ENTITY	Expression of CD146 adhesion molecules -LRB- MUC18 or MCAM -RRB- in the thymic microenvironment .
21239604	0	MUC18	17,22	IL-13	53,58	MUC18	IL-13	4162	3596	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Up-regulation of MUC18 in airway epithelial cells by IL-13 : implications in bacterial adherence .
12559945	0	MUC2	51,55	CDX2	20,24	MUC2	CDX2	4583	1045	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression .
17576890	0	MUC2	86,90	CDX2	107,111	MUC2	CDX2	4583	1045	Gene	Gene	START_ENTITY|nmod|concert concert|nmod|END_ENTITY	Pathogenesis of Barrett_esophagus : deoxycholic_acid up-regulates goblet-specific gene MUC2 in concert with CDX2 in human esophageal cells .
25543044	1	MUC2	74,78	ERK	105,108	MUC2	ERK	4583	5594	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	inhibit PMA-induced MUC2 and MUC5AC expression via ERK inhibition in human airway epithelial cells .
12391274	0	MUC2	26,30	Interleukin-1beta	0,17	MUC2	Interleukin-1beta	4583	3553	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells .
12482999	0	MUC2	26,30	Interleukin-1beta	0,17	MUC2	Interleukin-1beta	4583	3553	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK , and PI3K in human airway epithelial cells .
11889602	0	MUC2	13,17	MUC1	7,11	MUC2	MUC1	4583	4582	Gene	Gene	Mucins|nummod|START_ENTITY Mucins|nummod|END_ENTITY	Mucins MUC1 , MUC2 , MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric_carcinoma .
9422745	0	MUC2	18,22	MUC3	24,28	MUC2	MUC3	4583	100133790	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
8910010	0	MUC2	38,42	MUC4	44,48	MUC2	MUC4	24572(Tax:10116)	303887(Tax:10116)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The transcripts of the apomucin genes MUC2 , MUC4 , and MUC5AC are large and appear as distinct bands .
9422745	0	MUC2	18,22	MUC4	30,34	MUC2	MUC4	4583	4585	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
10567212	0	MUC2	53,57	MUC5AC	25,31	MUC2	MUC5AC	4583	4586	Gene	Gene	mucins|nummod|START_ENTITY amounts|nmod|mucins amounts|compound|END_ENTITY	Identification of MUC5B , MUC5AC and small amounts of MUC2 mucins in cystic_fibrosis airway secretions .
11889602	0	MUC2	13,17	MUC5AC	19,25	MUC2	MUC5AC	4583	4586	Gene	Gene	Mucins|nummod|START_ENTITY Mucins|nummod|END_ENTITY	Mucins MUC1 , MUC2 , MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric_carcinoma .
12493022	0	MUC2	28,32	MUC5AC	34,40	MUC2	MUC5AC	4583	4586	Gene	Gene	MUC1|dep|START_ENTITY MUC1|dep|END_ENTITY	Expression of mucins -LRB- MUC1 , MUC2 , MUC5AC and MUC6 -RRB- in mucinous_carcinoma_of_the_breast : comparison with invasive_ductal_carcinoma .
12877727	0	MUC2	84,88	MUC5AC	90,96	MUC2	MUC5AC	4583	4586	Gene	Gene	MUC1|dep|START_ENTITY MUC1|dep|END_ENTITY	Immunoreactivity of cytokeratins -LRB- CK7 , CK20 -RRB- and mucin peptide core antigens -LRB- MUC1 , MUC2 , MUC5AC -RRB- in adenocarcinomas , normal and metaplastic tissues of the distal oesophagus , oesophago-gastric junction and proximal stomach .
16988760	0	MUC2	22,26	MUC5AC	28,34	MUC2	MUC5AC	4583	4586	Gene	Gene	MUC6|compound|START_ENTITY MUC6|appos|END_ENTITY	Phenotype analysis by MUC2 , MUC5AC , MUC6 , and CD10 expression in Epstein-Barr_virus-associated_gastric_carcinoma .
18493590	0	MUC2	92,96	MUC5AC	98,104	MUC2	MUC5AC	4583	4586	Gene	Gene	MUC6|compound|START_ENTITY MUC6|dep|END_ENTITY	Alterations in mucin expression in ovarian_mucinous_tumors : immunohistochemical analysis of MUC2 , MUC5AC , MUC6 , and CD10 expression .
22261707	0	MUC2	38,42	MUC5AC	24,30	MUC2	MUC5AC	4583	4586	Gene	Gene	CD10|appos|START_ENTITY CD10|compound|END_ENTITY	Divergent expression of MUC5AC , MUC6 , MUC2 , CD10 , and CDX-2 in dysplasia and intramucosal_adenocarcinomas with intestinal and foveolar morphology : is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett_Esophagus ?
26060493	0	MUC2	78,82	MUC5AC	84,90	MUC2	MUC5AC	4583	4586	Gene	Gene	MUC6|compound|START_ENTITY MUC6|appos|END_ENTITY	Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2 , MUC5AC , MUC6 , p53 , and Clinicopathological Characteristics in Gastric_Cancer Patients with Curative Resection .
9422745	0	MUC2	18,22	MUC5AC	36,42	MUC2	MUC5AC	4583	4586	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9761738	0	MUC2	82,86	MUC5AC	6,12	MUC2	MUC5AC	4583	4586	Gene	Gene	mucin|compound|START_ENTITY dimerizes|nmod|mucin dimerizes|nsubj|mucin mucin|compound|END_ENTITY	Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum , similarly to the MUC2 mucin .
10567212	0	MUC2	53,57	MUC5B	18,23	MUC2	MUC5B	4583	727897	Gene	Gene	mucins|nummod|START_ENTITY amounts|nmod|mucins amounts|compound|MUC5AC MUC5AC|compound|END_ENTITY	Identification of MUC5B , MUC5AC and small amounts of MUC2 mucins in cystic_fibrosis airway secretions .
9422745	0	MUC2	18,22	MUC5B	44,49	MUC2	MUC5B	4583	727897	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
8838089	0	MUC2	45,49	Mucin	1,6	MUC2	Mucin	4583	100508689	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulation|nmod|expression gene|dep|regulation gene|compound|END_ENTITY	-LSB- Mucin gene -- regulation of the expression of MUC2 and MUC3 mucin gene in the airway -RSB- .
15665513	0	MUC2	20,24	NF-kappaB	43,52	MUC2	NF-kappaB	4583	4790	Gene	Gene	transcription|nummod|START_ENTITY transcription|nmod|END_ENTITY	TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation .
7988497	0	MUC2	36,40	lysozyme	16,24	MUC2	lysozyme	4583	4069	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Distribution of lysozyme and mucin -LRB- MUC2 and MUC3 -RRB- mRNA in human bronchus .
10070955	0	MUC2	82,86	mucin	69,74	MUC2	mucin	4583	100508689	Gene	Gene	MUC1|appos|START_ENTITY expression|dep|MUC1 expression|compound|END_ENTITY	Intestinal metaplasia of human stomach displays distinct patterns of mucin -LRB- MUC1 , MUC2 , MUC5AC , and MUC6 -RRB- expression .
10872659	0	MUC2	27,31	mucin	43,48	MUC2	mucin	4583	100508689	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Differential expression of MUC2 and MUC5AC mucin genes in primary ovarian and metastatic colonic_carcinoma .
11062147	0	MUC2	77,81	mucin	22,27	MUC2	mucin	4583	100508689	Gene	Gene	significance|nmod|START_ENTITY Polymorphism|dep|significance Polymorphism|nmod|genes genes|compound|END_ENTITY	Polymorphism of human mucin genes in chest_disease : possible significance of MUC2 .
11368880	0	MUC2	35,39	mucin	29,34	MUC2	mucin	4583	100508689	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of the intestinal mucin MUC2 gene expression in vivo : evidence for the role of promoter methylation .
12490305	0	MUC2	59,63	mucin	64,69	MUC2	mucin	4583	100508689	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric_carcinomas .
15345696	0	MUC2	43,47	mucin	31,36	MUC2	mucin	4583	100508689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Adenosine up-regulation of the mucin gene , MUC2 , in asthma .
16285957	0	MUC2	21,25	mucin	26,31	MUC2	mucin	4583	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Galectin-3 modulates MUC2 mucin expression in human colon_cancer cells at the level of transcription via AP-1 activation .
17674761	0	MUC2	18,22	mucin	23,28	MUC2	mucin	4583	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Up-regulation of MUC2 mucin gene in chronic rhinosinusitis -RSB- .
18493590	0	MUC2	92,96	mucin	15,20	MUC2	mucin	4583	100508689	Gene	Gene	MUC6|compound|START_ENTITY analysis|nmod|MUC6 Alterations|dep|analysis Alterations|nmod|expression expression|compound|END_ENTITY	Alterations in mucin expression in ovarian_mucinous_tumors : immunohistochemical analysis of MUC2 , MUC5AC , MUC6 , and CD10 expression .
1980995	0	MUC2	53,57	mucin	41,46	MUC2	mucin	4583	100508689	Gene	Gene	Assignment|appos|START_ENTITY Assignment|nmod|gene gene|compound|END_ENTITY	Assignment of the polymorphic intestinal mucin gene -LRB- MUC2 -RRB- to chromosome 11p15 .
7492301	0	MUC2	39,43	mucin	44,49	MUC2	mucin	4583	100508689	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Regulated and unregulated pathways for MUC2 mucin secretion in human colonic LS180 adenocarcinoma cells are distinct .
8020672	0	MUC2	23,27	mucin	16,21	MUC2	mucin	4583	100508689	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of mucin -LRB- MUC2 and MUC3 -RRB- messenger RNA and peptide expression in human normal intestine and colon_cancer .
8143972	0	MUC2	22,26	mucin	43,48	MUC2	mucin	4583	100508689	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Altered expression of MUC2 , MUC4 , and MUC5 mucin genes in pancreas tissues and cancer cell lines .
8227409	0	MUC2	14,18	mucin	30,35	MUC2	mucin	4583	100508689	Gene	Gene	Expression|nmod|START_ENTITY epithelial|nsubj|Expression epithelial|dobj|END_ENTITY	Expression of MUC2 epithelial mucin in breast_carcinoma .
8838089	0	MUC2	45,49	mucin	59,64	MUC2	mucin	4583	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Mucin gene -- regulation of the expression of MUC2 and MUC3 mucin gene in the airway -RSB- .
8948445	0	MUC2	10,14	mucin	116,121	MUC2	mucin	4583	100508689	Gene	Gene	apoprotein|compound|START_ENTITY appears|nsubj|apoprotein appears|xcomp|dimerize dimerize|nmod|epitopes epitopes|nmod|END_ENTITY	The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the ` insoluble ' mucin of rat small intestine .
8948445	0	MUC2	10,14	mucin	15,20	MUC2	mucin	4583	100508689	Gene	Gene	apoprotein|compound|START_ENTITY apoprotein|compound|END_ENTITY	The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the ` insoluble ' mucin of rat small intestine .
8997274	0	MUC2	59,63	mucin	16,21	MUC2	mucin	4583	100508689	Gene	Gene	induction|nmod|START_ENTITY reveals|dobj|induction reveals|nsubj|Quantitation Quantitation|nmod|RNA RNA|compound|END_ENTITY	Quantitation of mucin RNA by PCR reveals induction of both MUC2 and MUC5AC mRNA levels by retinoids .
9035693	0	MUC2	35,39	mucin	51,56	MUC2	mucin	4583	100508689	Gene	Gene	biosynthesis|nmod|START_ENTITY steps|nmod|biosynthesis epithelial|nsubj|steps epithelial|dobj|END_ENTITY	Early steps in the biosynthesis of MUC2 epithelial mucin in colon_cancer cells .
9065467	0	MUC2	72,76	mucin	60,65	MUC2	mucin	4583	100508689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Organization and regulatory aspects of the human intestinal mucin gene -LRB- MUC2 -RRB- locus .
9224654	0	MUC2	43,47	mucin	66,71	MUC2	mucin	4583	100508689	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of the MUC2 -LRB- human intestinal mucin -RRB- gene 5 ' - flanking region : promoter activity in cultured cells .
9422745	0	MUC2	18,22	mucin	6,11	MUC2	mucin	4583	100508689	Gene	Gene	genes|nummod|START_ENTITY express|nsubj|genes END_ENTITY|ccomp|express	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9569234	0	MUC2	45,49	mucin	100,105	MUC2	mucin	4583	100508689	Gene	Gene	MUC1|nummod|START_ENTITY analysis|nmod|MUC1 analysis|dep|correlation correlation|nmod|expression expression|compound|END_ENTITY	Quantitative analysis of mRNA encoding MUC1 , MUC2 , and MUC5AC genes : a correlation between specific mucin gene expression and sialomucin expression in non-small cell lung_cancer .
9722984	0	MUC2	4,8	mucin	42,47	MUC2	mucin	4583	100508689	Gene	Gene	product|compound|START_ENTITY product|dep|END_ENTITY	The MUC2 gene product : a human intestinal mucin .
9922317	0	MUC2	85,89	mucin	90,95	MUC2	mucin	4583	100508689	Gene	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Liver colonization by human colon_cancer cells is reduced by antisense inhibition of MUC2 mucin synthesis .
9422745	0	MUC3	24,28	MUC2	18,22	MUC3	MUC2	100133790	4583	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9422745	0	MUC3	24,28	MUC4	30,34	MUC3	MUC4	100133790	4585	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9422745	0	MUC3	24,28	MUC5AC	36,42	MUC3	MUC5AC	100133790	4586	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9422745	0	MUC3	24,28	MUC5B	44,49	MUC3	MUC5B	100133790	727897	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
12508093	0	MUC3	111,115	mucin	116,121	MUC3	mucin	100133790	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The conserved TFLK motif of mammary-associated serum amyloid A3 is responsible for up-regulation of intestinal MUC3 mucin expression in vitro .
12740338	0	MUC3	14,18	mucin	19,24	MUC3	mucin	100133790	100508689	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro .
1362870	0	MUC3	51,55	mucin	40,45	MUC3	mucin	100133790	100508689	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|gene gene|compound|END_ENTITY	Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22 .
9422745	0	MUC3	24,28	mucin	6,11	MUC3	mucin	100133790	100508689	Gene	Gene	genes|nummod|START_ENTITY express|nsubj|genes END_ENTITY|ccomp|express	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9931338	0	MUC3	93,97	mucin	81,86	MUC3	mucin	100133790	100508689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of ulcerative_colitis with rare VNTR alleles of the human intestinal mucin gene , MUC3 .
17621592	0	MUC4	56,60	AP-2alpha	21,30	MUC4	AP-2alpha	4585	7020	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Transcription factor AP-2alpha represses both the mucin MUC4 expression and pancreatic_cancer cell proliferation .
18397823	0	MUC4	0,4	ErbB2	20,25	MUC4	ErbB2	4585	2064	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	MUC4 interacts with ErbB2 in human gallbladder_carcinoma : potential pathobiological implications .
8910010	0	MUC4	44,48	MUC2	38,42	MUC4	MUC2	303887(Tax:10116)	24572(Tax:10116)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The transcripts of the apomucin genes MUC2 , MUC4 , and MUC5AC are large and appear as distinct bands .
9422745	0	MUC4	30,34	MUC2	18,22	MUC4	MUC2	4585	4583	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9422745	0	MUC4	30,34	MUC3	24,28	MUC4	MUC3	4585	100133790	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
21592537	0	MUC4	88,92	MUC5AC	37,43	MUC4	MUC5AC	100157344(Tax:9823)	100170143(Tax:9823)	Gene	Gene	mucins|appos|START_ENTITY mucins|dep|MUC2 MUC2|appos|END_ENTITY	Expression of secreted mucins -LRB- MUC2 , MUC5AC , MUC5B , and MUC6 -RRB- and membrane-bound mucin -LRB- MUC4 -RRB- in the lungs of pigs experimentally infected with Actinobacillus_pleuropneumoniae .
9422745	0	MUC4	30,34	MUC5AC	36,42	MUC4	MUC5AC	4585	4586	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9422745	0	MUC4	30,34	MUC5B	44,49	MUC4	MUC5B	4585	727897	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
24204560	0	MUC4	42,46	MicroRNA-200c	0,13	MUC4	MicroRNA-200c	4585	406985	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic_cancer .
11751498	0	MUC4	109,113	Mucin	0,5	MUC4	Mucin	4585	100508689	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Mucin -LRB- MUC -RRB- gene expression in human pancreatic_adenocarcinoma and chronic_pancreatitis : a potential role of MUC4 as a tumor marker of diagnostic significance .
1351710	0	MUC4	9,13	Mucin_4	0,7	MUC4	Mucin 4	4585	4585	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mucin_4 -LRB- MUC4 -RRB- gene : regional assignment -LRB- 3q29 -RRB- and RFLP analysis .
16799633	0	MUC4	0,4	cystic_fibrosis_transmembrane_conductance_regulator	32,83	MUC4	cystic fibrosis transmembrane conductance regulator	4585	1080	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	MUC4 expression is regulated by cystic_fibrosis_transmembrane_conductance_regulator in pancreatic_adenocarcinoma cells via transcriptional and post-translational mechanisms .
16007204	0	MUC4	29,33	interferon-gamma	48,64	MUC4	interferon-gamma	4585	3458	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic_acid in human pancreatic_tumour cells involves a reprogramming of signalling pathways .
11418607	0	MUC4	37,41	mucin	26,31	MUC4	mucin	4585	100508689	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Characterization of human mucin gene MUC4 promoter : importance of growth factors and proinflammatory cytokines for its regulation in pancreatic_cancer cells .
11596032	0	MUC4	12,16	mucin	17,22	MUC4	mucin	4585	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Analysis of MUC4 mucin expression in lung_carcinoma cells and its immunogenicity .
12153560	0	MUC4	24,28	mucin	29,34	MUC4	mucin	4585	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization of MUC4 mucin gene .
14760381	0	MUC4	0,4	mucin	5,10	MUC4	mucin	4585	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MUC4 mucin expression in human pancreatic_tumours is affected by organ environment : the possible role of TGFbeta2 .
16007204	0	MUC4	29,33	mucin	34,39	MUC4	mucin	4585	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic_acid in human pancreatic_tumour cells involves a reprogramming of signalling pathways .
20591909	0	MUC4	25,29	mucin	30,35	MUC4	mucin	4585	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Aberrant upregulation of MUC4 mucin expression in cutaneous_condyloma_acuminatum and squamous_cell_carcinoma suggests a potential role in the diagnosis and therapy of skin_diseases .
9422745	0	MUC4	30,34	mucin	6,11	MUC4	mucin	4585	100508689	Gene	Gene	genes|nummod|START_ENTITY express|nsubj|genes END_ENTITY|ccomp|express	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
19266212	0	MUC5AC	50,56	CDX2	90,94	MUC5AC	CDX2	17833(Tax:10090)	12591(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Juvenile_polyps have gastric differentiation with MUC5AC expression and downregulation of CDX2 and SMAD4 .
12403127	0	MUC5AC	17,23	IL-13	0,5	MUC5AC	IL-13	4586	3596	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	IL-13 suppresses MUC5AC gene expression and mucin secretion in nasal epithelial cells .
24487386	0	MUC5AC	19,25	IL-1b	0,5	MUC5AC	IL-1b	4586	3553	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	IL-1b induction of MUC5AC gene expression is mediated by CREB and NF-kB and repressed by dexamethasone .
14527933	0	MUC5AC	14,20	IL-1beta	77,85	MUC5AC	IL-1beta	4586	3553	Gene	Gene	secretion|compound|START_ENTITY Regulation|nmod|secretion surface|nsubj|Regulation surface|nmod|END_ENTITY	Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia .
19841186	0	MUC5AC	21,27	IL-1beta	42,50	MUC5AC	IL-1beta	4586	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of airway MUC5AC expression by IL-1beta and IL-17A ; the NF-kappaB paradigm .
24892823	0	MUC5AC	25,31	Interleukin-17A	0,15	MUC5AC	Interleukin-17A	4586	3605	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Interleukin-17A promotes MUC5AC expression and goblet cell hyperplasia in nasal_polyps via the Act1-mediated pathway .
11889602	0	MUC5AC	19,25	MUC1	7,11	MUC5AC	MUC1	4586	4582	Gene	Gene	Mucins|nummod|START_ENTITY Mucins|nummod|END_ENTITY	Mucins MUC1 , MUC2 , MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric_carcinoma .
10567212	0	MUC5AC	25,31	MUC2	53,57	MUC5AC	MUC2	4586	4583	Gene	Gene	amounts|compound|START_ENTITY amounts|nmod|mucins mucins|nummod|END_ENTITY	Identification of MUC5B , MUC5AC and small amounts of MUC2 mucins in cystic_fibrosis airway secretions .
11889602	0	MUC5AC	19,25	MUC2	13,17	MUC5AC	MUC2	4586	4583	Gene	Gene	Mucins|nummod|START_ENTITY Mucins|nummod|END_ENTITY	Mucins MUC1 , MUC2 , MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric_carcinoma .
12493022	0	MUC5AC	34,40	MUC2	28,32	MUC5AC	MUC2	4586	4583	Gene	Gene	MUC1|dep|START_ENTITY MUC1|dep|END_ENTITY	Expression of mucins -LRB- MUC1 , MUC2 , MUC5AC and MUC6 -RRB- in mucinous_carcinoma_of_the_breast : comparison with invasive_ductal_carcinoma .
12877727	0	MUC5AC	90,96	MUC2	84,88	MUC5AC	MUC2	4586	4583	Gene	Gene	MUC1|dep|START_ENTITY MUC1|dep|END_ENTITY	Immunoreactivity of cytokeratins -LRB- CK7 , CK20 -RRB- and mucin peptide core antigens -LRB- MUC1 , MUC2 , MUC5AC -RRB- in adenocarcinomas , normal and metaplastic tissues of the distal oesophagus , oesophago-gastric junction and proximal stomach .
16988760	0	MUC5AC	28,34	MUC2	22,26	MUC5AC	MUC2	4586	4583	Gene	Gene	MUC6|appos|START_ENTITY MUC6|compound|END_ENTITY	Phenotype analysis by MUC2 , MUC5AC , MUC6 , and CD10 expression in Epstein-Barr_virus-associated_gastric_carcinoma .
18493590	0	MUC5AC	98,104	MUC2	92,96	MUC5AC	MUC2	4586	4583	Gene	Gene	MUC6|dep|START_ENTITY MUC6|compound|END_ENTITY	Alterations in mucin expression in ovarian_mucinous_tumors : immunohistochemical analysis of MUC2 , MUC5AC , MUC6 , and CD10 expression .
22261707	0	MUC5AC	24,30	MUC2	38,42	MUC5AC	MUC2	4586	4583	Gene	Gene	CD10|compound|START_ENTITY CD10|appos|END_ENTITY	Divergent expression of MUC5AC , MUC6 , MUC2 , CD10 , and CDX-2 in dysplasia and intramucosal_adenocarcinomas with intestinal and foveolar morphology : is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett_Esophagus ?
26060493	0	MUC5AC	84,90	MUC2	78,82	MUC5AC	MUC2	4586	4583	Gene	Gene	MUC6|appos|START_ENTITY MUC6|compound|END_ENTITY	Correlations of Human Epithelial Growth Factor Receptor 2 Overexpression with MUC2 , MUC5AC , MUC6 , p53 , and Clinicopathological Characteristics in Gastric_Cancer Patients with Curative Resection .
9422745	0	MUC5AC	36,42	MUC2	18,22	MUC5AC	MUC2	4586	4583	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9761738	0	MUC5AC	6,12	MUC2	82,86	MUC5AC	MUC2	4586	4583	Gene	Gene	mucin|compound|START_ENTITY dimerizes|nsubj|mucin dimerizes|nmod|mucin mucin|compound|END_ENTITY	Human MUC5AC mucin dimerizes in the rough endoplasmic reticulum , similarly to the MUC2 mucin .
9422745	0	MUC5AC	36,42	MUC3	24,28	MUC5AC	MUC3	4586	100133790	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
21592537	0	MUC5AC	37,43	MUC4	88,92	MUC5AC	MUC4	100170143(Tax:9823)	100157344(Tax:9823)	Gene	Gene	MUC2|appos|START_ENTITY mucins|dep|MUC2 mucins|appos|END_ENTITY	Expression of secreted mucins -LRB- MUC2 , MUC5AC , MUC5B , and MUC6 -RRB- and membrane-bound mucin -LRB- MUC4 -RRB- in the lungs of pigs experimentally infected with Actinobacillus_pleuropneumoniae .
9422745	0	MUC5AC	36,42	MUC4	30,34	MUC5AC	MUC4	4586	4585	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
16540890	0	MUC5AC	17,23	MUC5B	114,119	MUC5AC	MUC5B	4586	727897	Gene	Gene	genes|compound|START_ENTITY Up-regulation|nmod|genes Up-regulation|nmod|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric_otitis media with effusion .
17471237	0	MUC5AC	95,101	MUC5B	103,108	MUC5AC	MUC5B	4586	727897	Gene	Gene	MUC2|dep|START_ENTITY MUC2|dep|MUC6 MUC6|compound|END_ENTITY	Epigenetic regulation -LRB- DNA methylation , histone modifications -RRB- of the 11p15 mucin genes -LRB- MUC2 , MUC5AC , MUC5B , MUC6 -RRB- in epithelial cancer cells .
9422745	0	MUC5AC	36,42	MUC5B	44,49	MUC5AC	MUC5B	4586	727897	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
22261707	0	MUC5AC	24,30	MUC6	32,36	MUC5AC	MUC6	4586	4588	Gene	Gene	CD10|compound|START_ENTITY CD10|appos|END_ENTITY	Divergent expression of MUC5AC , MUC6 , MUC2 , CD10 , and CDX-2 in dysplasia and intramucosal_adenocarcinomas with intestinal and foveolar morphology : is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett_Esophagus ?
12125997	0	MUC5AC	43,49	MUC8	16,20	MUC5AC	MUC8	4586	100129528	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal_polyps and cultured nasal epithelium .
21773870	0	MUC5AC	58,64	MiR-146a	0,8	MUC5AC	MiR-146a	4586	406938	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	MiR-146a negatively regulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells .
17197898	0	MUC5AC	25,31	Mucin	0,5	MUC5AC	Mucin	4586	100508689	Gene	Gene	MUC4|nummod|START_ENTITY MUC2|appos|MUC4 genes|dep|MUC2 genes|compound|END_ENTITY	Mucin genes -LRB- MUC2 , MUC4 , MUC5AC , and MUC6 -RRB- detection in normal and pathological endometrial tissues .
21254123	0	MUC5AC	7,13	Mucin	0,5	MUC5AC	Mucin	4586	100508689	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mucin -LRB- MUC5AC -RRB- expression by lung epithelial cells cultured in a microfluidic gradient device .
21998660	0	MUC5AC	125,131	Mucin	0,5	MUC5AC	Mucin	4586	100508689	Gene	Gene	association|nmod|START_ENTITY polymorphisms|dep|association polymorphisms|amod|END_ENTITY	Mucin variable number tandem repeat polymorphisms and severity of cystic_fibrosis lung_disease : significant association with MUC5AC .
17555715	0	MUC5AC	60,66	PAK2	18,22	MUC5AC	PAK2	4586	5062	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF .
15289936	0	MUC5AC	37,43	TFF1	20,24	MUC5AC	TFF1	4586	7031	Gene	Gene	bound|nmod|START_ENTITY bound|nsubjpass|END_ENTITY	The trefoil protein TFF1 is bound to MUC5AC in human gastric_mucosa .
12972643	0	MUC5AC	55,61	Tumor_necrosis_factor_alpha-converting_enzyme	0,45	MUC5AC	Tumor necrosis factor alpha-converting enzyme	4586	6868	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Tumor_necrosis_factor_alpha-converting_enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells .
20619258	0	MUC5AC	65,71	activator_protein-1	115,134	MUC5AC	activator protein-1	4586	3726	Gene	Gene	expression|nummod|START_ENTITY inhibits|dobj|expression inhibits|nmod|inhibition inhibition|nmod|cells cells|amod|END_ENTITY	Azithromycin inhibits nontypeable Haemophilus_influenzae-induced MUC5AC expression and secretion via inhibition of activator_protein-1 in human airway epithelial cells .
21131736	0	MUC5AC	66,72	activator_protein-1	25,44	MUC5AC	activator protein-1	17833(Tax:10090)	16476(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Regulatory mechanism of activator_protein-1 on the expression of MUC5AC induced by cigarette_smoke_extract -RSB- .
22348416	0	MUC5AC	0,6	cytokeratin_20	8,22	MUC5AC	cytokeratin 20	4586	54474	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	MUC5AC , cytokeratin_20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital_pulmonary_airway_malformations .
24975020	0	MUC5AC	71,77	extracellular_signal-regulated_kinase	82,119	MUC5AC	extracellular signal-regulated kinase	4586	5594	Gene	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	S100A8 , S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular_signal-regulated_kinase and nuclear factor-kB pathways .
10070955	0	MUC5AC	88,94	mucin	69,74	MUC5AC	mucin	4586	100508689	Gene	Gene	MUC2|nummod|START_ENTITY MUC1|appos|MUC2 expression|dep|MUC1 expression|compound|END_ENTITY	Intestinal metaplasia of human stomach displays distinct patterns of mucin -LRB- MUC1 , MUC2 , MUC5AC , and MUC6 -RRB- expression .
10681391	0	MUC5AC	102,108	mucin	52,57	MUC5AC	mucin	4586	100508689	Gene	Gene	study|appos|START_ENTITY study|nmod|expression expression|nmod|END_ENTITY	Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins -LRB- MUC5AC and MUC2 -RRB- in human gastric_carcinomas .
11052828	0	MUC5AC	31,37	mucin	82,87	MUC5AC	mucin	4586	100508689	Gene	Gene	secretion|compound|START_ENTITY regulation|nmod|secretion TNF-alpha|nmod|regulation TNF-alpha|dep|aspects aspects|nmod|hypersecretion hypersecretion|compound|END_ENTITY	TNF-alpha in the regulation of MUC5AC secretion : some aspects of cytokine-induced mucin hypersecretion on the in vitro model .
11415465	0	MUC5AC	89,95	mucin	96,101	MUC5AC	mucin	4586	100508689	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUC5AC mucin motif peptides .
11698399	0	MUC5AC	83,89	mucin	90,95	MUC5AC	mucin	4586	100508689	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Novel cytoplasmic proteins of nontypeable Haemophilus_influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway .
11923240	0	MUC5AC	42,48	mucin	36,41	MUC5AC	mucin	4586	100508689	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|END_ENTITY	Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sj gren syndrome .
15210557	0	MUC5AC	17,23	mucin	34,39	MUC5AC	mucin	4586	100508689	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis .
16055478	0	MUC5AC	59,65	mucin	66,71	MUC5AC	mucin	4586	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells .
16148149	0	MUC5AC	28,34	mucin	35,40	MUC5AC	mucin	4586	100508689	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C , reactive_oxygen_species , and TNF-alpha-converting_enzyme .
16425564	0	MUC5AC	32,38	mucin	39,44	MUC5AC	mucin	4586	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical analyses of MUC5AC mucin expression in sinus mucosa of children with sinusitis and controls .
16491824	0	MUC5AC	27,33	mucin	34,39	MUC5AC	mucin	4586	100508689	Gene	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Neutrophil elastase causes MUC5AC mucin synthesis via EGF receptor , ERK and NF-kB pathways in A549 cells .
16540890	0	MUC5AC	17,23	mucin	34,39	MUC5AC	mucin	4586	100508689	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric_otitis media with effusion .
17356062	0	MUC5AC	13,19	mucin	51,56	MUC5AC	mucin	4586	100508689	Gene	Gene	product|compound|START_ENTITY product|nmod|displays displays|compound|END_ENTITY	The isolated MUC5AC gene product from human ocular mucin displays intramolecular conformational heterogeneity .
17471237	0	MUC5AC	95,101	mucin	76,81	MUC5AC	mucin	4586	100508689	Gene	Gene	MUC2|dep|START_ENTITY genes|appos|MUC2 genes|compound|END_ENTITY	Epigenetic regulation -LRB- DNA methylation , histone modifications -RRB- of the 11p15 mucin genes -LRB- MUC2 , MUC5AC , MUC5B , MUC6 -RRB- in epithelial cancer cells .
17555715	0	MUC5AC	60,66	mucin	67,72	MUC5AC	mucin	4586	100508689	Gene	Gene	roles|nmod|START_ENTITY roles|acl|END_ENTITY	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF .
17621824	0	MUC5AC	18,24	mucin	35,40	MUC5AC	mucin	4586	100508689	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic_rhinosinusitis and nasal_polyposis .
18493590	0	MUC5AC	98,104	mucin	15,20	MUC5AC	mucin	4586	100508689	Gene	Gene	MUC6|dep|START_ENTITY analysis|nmod|MUC6 Alterations|dep|analysis Alterations|nmod|expression expression|compound|END_ENTITY	Alterations in mucin expression in ovarian_mucinous_tumors : immunohistochemical analysis of MUC2 , MUC5AC , MUC6 , and CD10 expression .
19288529	0	MUC5AC	64,70	mucin	71,76	MUC5AC	mucin	4586	100508689	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Genistein and curcumin suppress epidermal_growth_factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells .
19956440	0	MUC5AC	66,72	mucin	73,78	MUC5AC	mucin	4586	100508689	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Differential regulation of Streptococcus_pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways .
21146382	0	MUC5AC	21,27	mucin	28,33	MUC5AC	mucin	4586	100508689	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Inhibition of airway MUC5AC mucin production and gene expression induced by epidermal growth factor or phorbol_ester by glycyrrhizin and carbenoxolone .
21442679	2	MUC5AC	139,145	mucin	146,151	MUC5AC	mucin	4586	100508689	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	suppress epidermal growth factor - and phorbol_ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells .
21512244	0	MUC5AC	62,68	mucin	69,74	MUC5AC	mucin	4586	100508689	Gene	Gene	production|nummod|START_ENTITY production|compound|END_ENTITY	Inhibition of E-cadherin dependent cell-cell contact promotes MUC5AC mucin production through the activation of epidermal_growth_factor receptors .
22388989	0	MUC5AC	49,55	mucin	56,61	MUC5AC	mucin	4586	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Phorbol_ester or epidermal_growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin .
24496642	0	MUC5AC	26,32	mucin	14,19	MUC5AC	mucin	4586	100508689	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of mucin mRNA -LRB- MUC5AC and MUC5B -RRB- expression and protein production and secretion in Caco-2 / HT29-MTX co-cultures following exposure to individual and combined Fusarium mycotoxins .
25872410	0	MUC5AC	13,19	mucin	20,25	MUC5AC	mucin	4586	100508689	Gene	Gene	Induction|nmod|START_ENTITY END_ENTITY|nsubj|Induction	Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region .
25872410	0	MUC5AC	13,19	mucin	20,25	MUC5AC	mucin	4586	100508689	Gene	Gene	Induction|nmod|START_ENTITY END_ENTITY|nsubj|Induction	Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region .
7826332	0	MUC5AC	41,47	mucin	92,97	MUC5AC	mucin	4586	100508689	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|domain domain|nmod|genes genes|compound|END_ENTITY	Characterization of the human mucin gene MUC5AC : a consensus cysteine-rich domain for 11p15 mucin genes ?
8536891	0	MUC5AC	43,49	mucin	31,36	MUC5AC	mucin	4586	100508689	Gene	Gene	expression|appos|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	Aberrant expression of a human mucin gene -LRB- MUC5AC -RRB- in rectosigmoid_villous_adenoma .
9422745	0	MUC5AC	36,42	mucin	6,11	MUC5AC	mucin	4586	100508689	Gene	Gene	genes|nummod|START_ENTITY express|nsubj|genes END_ENTITY|ccomp|express	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9506983	0	MUC5AC	66,72	mucin	73,78	MUC5AC	mucin	4586	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Cloning of the amino-terminal and 5 ' - flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts .
9587664	0	MUC5AC	75,81	mucin	69,74	MUC5AC	mucin	4586	100508689	Gene	Gene	motif|compound|START_ENTITY motif|amod|END_ENTITY	Polypeptide : N-acetylgalactosaminyltransferase activities towards the mucin MUC5AC peptide motif using microsomal preparations of normal and tumoral digestive mucosa .
9620876	0	MUC5AC	51,57	mucin	134,139	MUC5AC	mucin	4586	100508689	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene organization|dep|region organization|dep|evidence evidence|nmod|gene gene|nmod|family family|compound|END_ENTITY	Genomic organization of the 3 ' - region of the human MUC5AC mucin gene : additional evidence for a common ancestral gene for the 11p15 .5 mucin gene family .
9620876	0	MUC5AC	51,57	mucin	58,63	MUC5AC	mucin	4586	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the 3 ' - region of the human MUC5AC mucin gene : additional evidence for a common ancestral gene for the 11p15 .5 mucin gene family .
9935202	0	MUC5AC	23,29	mucin	47,52	MUC5AC	mucin	4586	100508689	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Aberrant expression of MUC5AC and MUC6 gastric mucin genes in colorectal_polyps .
21418911	0	MUC5AC	71,77	sphingosine_kinase_1	15,35	MUC5AC	sphingosine kinase 1	4586	8877	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Regulation of sphingosine_kinase_1 in the TNF-a-induced expression of MUC5AC in airway epithelial cells -RSB- .
21619869	0	MUC5B	13,18	AMPK	0,4	MUC5B	AMPK	727897	5563	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells .
21832046	0	MUC5B	176,181	D-prostanoid_receptor	202,223	MUC5B	D-prostanoid receptor	727897	5729	Gene	Gene	expression|compound|START_ENTITY expression|nmod|signaling signaling|compound|END_ENTITY	The extracellular_signal-regulated_kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP_response_element-binding_protein to induce MUC5B gene expression via D-prostanoid_receptor signaling .
21618303	0	MUC5B	26,31	ERK2	47,51	MUC5B	ERK2	727897	5594	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Diallyl_disulfide induces MUC5B expression via ERK2 in human airway epithelial cells .
20935193	0	MUC5B	41,46	IL-1b	15,20	MUC5B	IL-1b	727897	3553	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	NF-kB mediates IL-1b - and IL-17A-induced MUC5B expression in airway epithelial cells .
20497020	0	MUC5B	20,25	Leptin	0,6	MUC5B	Leptin	727897	3952	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway .
22232712	0	MUC5B	41,46	MMP-9	62,67	MUC5B	MMP-9	727897	4318	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells .
10567212	0	MUC5B	18,23	MUC2	53,57	MUC5B	MUC2	727897	4583	Gene	Gene	MUC5AC|compound|START_ENTITY amounts|compound|MUC5AC amounts|nmod|mucins mucins|nummod|END_ENTITY	Identification of MUC5B , MUC5AC and small amounts of MUC2 mucins in cystic_fibrosis airway secretions .
9422745	0	MUC5B	44,49	MUC2	18,22	MUC5B	MUC2	727897	4583	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9422745	0	MUC5B	44,49	MUC3	24,28	MUC5B	MUC3	727897	100133790	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9422745	0	MUC5B	44,49	MUC4	30,34	MUC5B	MUC4	727897	4585	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
16540890	0	MUC5B	114,119	MUC5AC	17,23	MUC5B	MUC5AC	727897	4586	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|genes genes|compound|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric_otitis media with effusion .
17471237	0	MUC5B	103,108	MUC5AC	95,101	MUC5B	MUC5AC	727897	4586	Gene	Gene	MUC6|compound|START_ENTITY MUC2|dep|MUC6 MUC2|dep|END_ENTITY	Epigenetic regulation -LRB- DNA methylation , histone modifications -RRB- of the 11p15 mucin genes -LRB- MUC2 , MUC5AC , MUC5B , MUC6 -RRB- in epithelial cancer cells .
9422745	0	MUC5B	44,49	MUC5AC	36,42	MUC5B	MUC5AC	727897	4586	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
26871673	0	MUC5B	0,5	MUC5B	42,47	MUC5B	MUC5B	727897	727897	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic_Pulmonary_Fibrosis .
26871673	0	MUC5B	42,47	MUC5B	0,5	MUC5B	MUC5B	727897	727897	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	MUC5B Promoter Variant rs35705950 Affects MUC5B Expression in the Distal Airways in Idiopathic_Pulmonary_Fibrosis .
24717875	0	MUC5B	37,42	Toll-like_receptor_2	58,78	MUC5B	Toll-like receptor 2	727897	7097	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Staphylococcus enterotoxin A induces MUC5B expression via Toll-like_receptor_2 , extracellular_signal-regulated_kinase_1 / 2 , and p38_mitogen-activated_protein_kinase in human airway epithelial cells .
10764016	0	MUC5B	18,23	mucin	24,29	MUC5B	mucin	727897	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Identification of MUC5B mucin gene in human middle ear with chronic_otitis_media .
16540890	0	MUC5B	114,119	mucin	34,39	MUC5B	mucin	727897	100508689	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|genes genes|compound|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric_otitis media with effusion .
9422745	0	MUC5B	44,49	mucin	6,11	MUC5B	mucin	727897	100508689	Gene	Gene	genes|nummod|START_ENTITY express|nsubj|genes END_ENTITY|ccomp|express	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
22261707	0	MUC6	32,36	MUC5AC	24,30	MUC6	MUC5AC	4588	4586	Gene	Gene	CD10|appos|START_ENTITY CD10|compound|END_ENTITY	Divergent expression of MUC5AC , MUC6 , MUC2 , CD10 , and CDX-2 in dysplasia and intramucosal_adenocarcinomas with intestinal and foveolar morphology : is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett_Esophagus ?
10209489	0	MUC6	4,8	mucin	19,24	MUC6	mucin	4588	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues .
21851820	0	MUC6	0,4	mucin	5,10	MUC6	mucin	4588	100508689	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	MUC6 mucin expression inhibits tumor cell invasion .
20802811	0	MUC7	20,24	Mucin	25,30	MUC7	Mucin	4589	100508689	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Regulation of Human MUC7 Mucin Gene Expression by Cigarette Smoke Extract or Cigarette Smoke and Pseudomonas_aeruginosa Lipopolysaccharide in Human Airway Epithelial Cells and in MUC7 Transgenic_Mice .
10372967	0	MUC7	32,36	mucin	37,42	MUC7	mucin	4589	100508689	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	In-situ hybridization localized MUC7 mucin gene expression to the mucous acinar cells of human and MUC7-transgenic mouse salivary glands .
10642514	0	MUC7	63,67	mucin	52,57	MUC7	mucin	4589	100508689	Gene	Gene	MG2|appos|START_ENTITY MG2|compound|END_ENTITY	The recombinant N-terminal region of human salivary mucin MG2 -LRB- MUC7 -RRB- contains a binding domain for oral Streptococci and exhibits candidacidal activity .
14508262	0	MUC7	65,69	mucin	70,75	MUC7	mucin	4589	100508689	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Human epithelium from conjunctival impression cytology expresses MUC7 mucin gene .
16203048	0	MUC7	44,48	mucin	38,43	MUC7	mucin	4589	100508689	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Two-hybrid analysis of human salivary mucin MUC7 interactions .
16514118	0	MUC7	14,18	mucin	19,24	MUC7	mucin	4589	100508689	Gene	Gene	Modulation|nmod|START_ENTITY END_ENTITY|nsubj|Modulation	Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo .
16778149	0	MUC7	29,33	mucin	34,39	MUC7	mucin	4589	100508689	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Functional analysis of human MUC7 mucin gene 5 ' - flanking region in lung epithelial cells .
8838308	0	MUC7	73,77	mucin	61,66	MUC7	mucin	4589	100508689	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|gene gene|compound|END_ENTITY	Structure and chromosomal localization of the human salivary mucin gene , MUC7 .
23211593	0	MUC8	37,41	ERK1	67,71	MUC8	ERK1	100129528	5595	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Insulin-like_growth_factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells .
25975246	0	MUC8	26,30	ERK2	72,76	MUC8	ERK2	100129528	5594	Gene	Gene	expressions|compound|START_ENTITY expressions|nmod|END_ENTITY	Asian_sand_dust increases MUC8 and MUC5B expressions via TLR4-dependent ERK2 and p38 MAPK in human airway epithelial cells .
23211593	0	MUC8	37,41	Insulin-like_growth_factor-1	0,28	MUC8	Insulin-like growth factor-1	100129528	3479	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 induces MUC8 and MUC5B expression via ERK1 and p38 MAPK in human airway epithelial cells .
12125997	0	MUC8	16,20	MUC5AC	43,49	MUC8	MUC5AC	100129528	4586	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal_polyps and cultured nasal epithelium .
24885580	0	MUC8	17,21	Visfatin	0,8	MUC8	Visfatin	100129528	10135	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-kB in human airway epithelial cells .
12842905	0	MUC8	13,17	interleukin-1_beta	37,55	MUC8	interleukin-1 beta	100129528	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of MUC8 gene expression by interleukin-1_beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells .
9070607	0	MUC8	48,52	mucin	36,41	MUC8	mucin	100129528	100508689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal localization of a human mucin gene -LRB- MUC8 -RRB- and cloning of the cDNA corresponding to the carboxy terminus .
22028245	0	MUC9	31,35	mucin_9	22,29	MUC9	mucin 9	5016	5016	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of mucin_9 -LRB- MUC9 -RRB- in patients with ulcerative_colitis .
9688648	0	MUCLIN	54,60	mucinlike_glycoprotein	30,52	MUCLIN	mucinlike glycoprotein	12945(Tax:10090)	12945(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of a mucinlike_glycoprotein -LRB- MUCLIN -RRB- in pancreas and small intestine of CF mice .
8027037	0	MUC_2	56,61	mucin	62,67	MUC 2	mucin	4583	65202(Tax:10116)	Gene	Gene	homologue|compound|START_ENTITY homologue|compound|END_ENTITY	Molecular cloning of the amino-terminal region of a rat MUC_2 mucin gene homologue .
9370281	0	MUC_2	47,52	mucin	53,58	MUC 2	mucin	24572(Tax:10116)	65202(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Sp1 protein contributes to airway-specific rat MUC_2 mucin gene transcription .
22056942	0	MULAN	90,95	mitochondrial_ubiquitin_ligase_activator_of_NF-kB	39,88	MULAN	mitochondrial ubiquitin ligase activator of NF-kB	101448023	101448023	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Cloning and expression analysis of the mitochondrial_ubiquitin_ligase_activator_of_NF-kB -LRB- MULAN -RRB- in Atlantic_salmon -LRB- Salmo_salar -RRB- .
26655500	0	MULTIMERIN2	0,11	VEGF-A	18,24	MULTIMERIN2	VEGF-A	79812	7422	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth .
6549044	0	MUP	53,56	major_urinary_protein	30,51	MUP	major urinary protein	381531(Tax:10090)	381531(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Tissue-specific expression of major_urinary_protein -LRB- MUP -RRB- genes in mice : characterization of MUP mRNAs by restriction mapping of cDNA and by in vitro translation .
15364909	0	MUPP-1	90,96	coxsackievirus_and_adenovirus_receptor	4,42	MUPP-1	coxsackievirus and adenovirus receptor	8777	1525	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The coxsackievirus_and_adenovirus_receptor interacts with the multi-PDZ_domain_protein-1 -LRB- MUPP-1 -RRB- within the tight junction .
23880463	0	MUPP-1	32,38	multi-PDZ_domain_protein-1	4,30	MUPP-1	multi-PDZ domain protein-1	8777	8777	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	The multi-PDZ_domain_protein-1 -LRB- MUPP-1 -RRB- expression regulates cellular levels of the PALS-1 / PATJ polarity complex .
10967549	0	MUPP1	29,34	NG2	98,101	MUPP1	NG2	8777	1464	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2 .
24001173	0	MURC	57,61	muscle-restricted_coiled-coil_protein	18,55	MURC	muscle-restricted coiled-coil protein	313225(Tax:10116)	313225(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hypoxia activates muscle-restricted_coiled-coil_protein -LRB- MURC -RRB- expression via transforming growth factor-b in cardiac myocytes .
21686210	0	MURF1	34,39	muscle_ring-finger-1	12,32	MURF1	muscle ring-finger-1	433766(Tax:10090)	433766(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Rise above : muscle_ring-finger-1 -LRB- MURF1 -RRB- regulation of cardiomyocyte size and energy metabolism .
16293123	0	MURR1	32,37	COMMD1	24,30	MURR1	COMMD1	403590(Tax:9615)	403590(Tax:9615)	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Characterization of the COMMD1 -LRB- MURR1 -RRB- mutation causing copper_toxicosis in Bedlington terriers .
24525742	0	MUSASHI-1	27,36	NOTCH3	0,6	MUSASHI-1	NOTCH3	4440	4854	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|signaling signaling|compound|END_ENTITY	NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal_cancer cells .
15653635	0	MUT-7	21,26	RDE-2	0,5	MUT-7	RDE-2	176347(Tax:6239)	172473(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis_elegans .
26576226	0	MUTYH	14,19	DNA_Repair_Enzyme	23,40	MUTYH	DNA Repair Enzyme	4595	3981	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of MUTYH , a DNA_Repair_Enzyme , in Renal Proximal Tubular Epithelial Cells .
10975410	0	MVDP	75,79	mouse_vas_deferens_protein	47,73	MVDP	mouse vas deferens protein	11997(Tax:10090)	11997(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Acquisition of androgen-mediated expression of mouse_vas_deferens_protein -LRB- MVDP -RRB- gene in cultured epithelial cells and in vas deferens during postnatal development .
11313768	0	MVK	39,42	mevalonate_kinase	20,37	MVK	mevalonate kinase	4598	4598	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Organization of the mevalonate_kinase -LRB- MVK -RRB- gene and identification of novel mutations causing mevalonic_aciduria and hyperimmunoglobulinaemia D and periodic_fever_syndrome .
24084495	0	MVK	36,39	mevalonate_kinase	17,34	MVK	mevalonate kinase	4598	4598	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the mevalonate_kinase -LRB- MVK -RRB- gene cause nonsyndromic retinitis_pigmentosa .
15749954	0	MVP	67,70	major_vault_protein	46,65	MVP	major vault protein	9961	9961	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Expression and proteasomal degradation of the major_vault_protein -LRB- MVP -RRB- in mammalian oocytes and zygotes .
10942113	0	MX1	85,88	p78	72,75	MX1	p78	4599	10445	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Structure and polymorphism of the human gene for the interferon-induced p78 protein -LRB- MX1 -RRB- : evidence of association with alopecia areata in the Down syndrome region .
19254710	0	MXI1	19,23	HIF-1alpha	0,10	MXI1	HIF-1alpha	4601	3091	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells .
10497252	0	MXI1	14,18	Sp1	54,57	MXI1	Sp1	4601	6667	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of MXI1 , a Myc antagonist , is regulated by Sp1 and AP2 .
21325632	0	MYADM	0,5	Rac1	16,20	MYADM	Rac1	91663	5879	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration .
16172915	0	MYADM	73,78	myeloid-associated_differentiation_marker	30,71	MYADM	myeloid-associated differentiation marker	50918(Tax:10090)	50918(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the mouse myeloid-associated_differentiation_marker -LRB- MYADM -RRB- gene : promoter analysis and protein localization .
15540222	0	MYB	42,45	HLXB9	14,19	MYB	HLXB9	4602	3110	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of HLXB9 by juxtaposition with MYB via formation of t -LRB- 6 ; 7 -RRB- -LRB- q23 ; q36 -RRB- in an AML-M4 cell line -LRB- GDM-1 -RRB- .
24486218	0	MYB	105,108	MicroRNA-195	0,12	MYB	MicroRNA-195	4602	406971	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-195 inhibits non-small_cell_lung_cancer cell proliferation , migration and invasion by targeting MYB .
21296997	0	MYB	0,3	miR-155	36,43	MYB	miR-155	4602	406947	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	MYB transcriptionally regulates the miR-155 host gene in chronic_lymphocytic_leukemia .
19091873	0	MYB108	0,6	MYB24	26,31	MYB108	MYB24	819827(Tax:3702)	834033(Tax:3702)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	MYB108 acts together with MYB24 to regulate jasmonate-mediated stamen maturation in Arabidopsis .
19091873	0	MYB24	26,31	MYB108	0,6	MYB24	MYB108	834033(Tax:3702)	819827(Tax:3702)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	MYB108 acts together with MYB24 to regulate jasmonate-mediated stamen maturation in Arabidopsis .
19808805	0	MYB83	0,5	SND1	28,32	MYB83	SND1	819997(Tax:3702)	840171(Tax:3702)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MYB83 is a direct target of SND1 and acts redundantly with MYB46 in the regulation of secondary cell wall biosynthesis in Arabidopsis .
25543088	0	MYBBP1A	51,58	Myb-binding_protein_1A	27,49	MYBBP1A	Myb-binding protein 1A	10514	10514	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation and function of Myb-binding_protein_1A -LRB- MYBBP1A -RRB- in cellular senescence and pathogenesis of head_and_neck_cancer .
21297583	0	MYBBP1A	56,63	p53	36,39	MYBBP1A	p53	10514	7157	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|compound|END_ENTITY	RNA content in the nucleolus alters p53 acetylation via MYBBP1A .
26044764	0	MYBBP1A	83,90	p53	49,52	MYBBP1A	p53	10514	7157	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|compound|END_ENTITY	Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A .
17196614	0	MYBBP1a	0,7	NF-kappaB	32,41	MYBBP1a	NF-kappaB	10514	4790	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	MYBBP1a is a novel repressor of NF-kappaB .
21750041	0	MYBL1	7,12	A-MYB	0,5	MYBL1	A-MYB	4603	4603	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	A-MYB -LRB- MYBL1 -RRB- transcription factor is a master regulator of male meiosis .
23169658	0	MYBL2	0,5	BIN2	41,45	MYBL2	BIN2	843443(Tax:3702)	827605(Tax:3702)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	MYBL2 is a substrate of GSK3-like kinase BIN2 and acts as a corepressor of BES1 in brassinosteroid signaling pathway in Arabidopsis .
23068101	0	MYBPH	0,5	NMHC_IIA	59,67	MYBPH	NMHC IIA	4608	4627	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MYBPH inhibits NM_IIA_assembly via direct interaction with NMHC_IIA and reduces cell motility .
22085929	0	MYBPH	0,5	ROCK1	51,56	MYBPH	ROCK1	4608	6093	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	MYBPH , a transcriptional target of TTF-1 , inhibits ROCK1 , and reduces cell motility and metastasis .
22085929	0	MYBPH	0,5	TTF-1	35,40	MYBPH	TTF-1	4608	7270	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	MYBPH , a transcriptional target of TTF-1 , inhibits ROCK1 , and reduces cell motility and metastasis .
20345602	0	MYB_transcription_factor	16,40	CHS8	62,66	MYB transcription factor	CHS8	100780023	100170701(Tax:3847)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	A single-repeat MYB_transcription_factor , GmMYB176 , regulates CHS8 gene expression and affects isoflavonoid biosynthesis in soybean .
22140235	0	MYB_transcription_factor	30,54	TaMYB73	61,68	MYB transcription factor	TaMYB73	100286389(Tax:4565)	100873129	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Ectopic expression of a wheat MYB_transcription_factor gene , TaMYB73 , improves salinity stress tolerance in Arabidopsis_thaliana .
21394210	0	MYC	0,3	AKT	20,23	MYC	AKT	4609	207	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors .
24299953	0	MYC	24,27	AXIN2	8,13	MYC	AXIN2	4609	8313	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Nuclear AXIN2 represses MYC gene expression .
25297597	0	MYC	23,26	BCL6	17,21	MYC	BCL6	4609	604	Gene	Gene	abnormalities|appos|START_ENTITY abnormalities|compound|END_ENTITY	-LSB- Significance of BCL6 , MYC , P53 genes abnormalities for the prognosis of diffuse_large_B-cell_lymphoma -RSB- .
26966191	0	MYC	0,3	CD47	52,56	MYC	CD47	4609	961	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MYC regulates the antitumor immune response through CD47 and PD-L1 .
16760655	0	MYC	20,23	CDK2	0,4	MYC	CDK2	4609	1017	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	CDK2 is required by MYC to induce apoptosis .
18713946	0	MYC	0,3	EZH2	15,19	MYC	EZH2	4609	2146	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	MYC stimulates EZH2 expression by repression of its negative regulator miR-26a .
25669969	0	MYC	0,3	FBXW7	28,33	MYC	FBXW7	4609	55294	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MYC is a critical target of FBXW7 .
19938013	0	MYC	23,26	Hepsin	0,6	MYC	Hepsin	17869(Tax:10090)	15451(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate_cancer mouse model .
26035700	0	MYC	24,27	MYCN	35,39	MYC	MYCN	4609	4613	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma : a Children 's Oncology Group study .
26335888	0	MYC	67,70	MicroRNA-34a	0,12	MYC	MicroRNA-34a	4609	407040	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-34a inhibits human trophoblast cell invasion by targeting MYC .
3099296	0	MYC	31,34	Tumor_necrosis_factor	0,21	MYC	Tumor necrosis factor	4609	7124	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription .
22396492	0	MYC	132,135	cyclin_D1	122,131	MYC	cyclin D1	4609	595	Gene	Gene	promoters|compound|START_ENTITY promoters|amod|END_ENTITY	Estrogen_receptor_alpha mediates progestin-induced mammary tumor growth by interacting with progesterone_receptors at the cyclin_D1 / MYC promoters .
17639584	0	MYC	47,50	immunoglobulin_heavy-chain	14,40	MYC	immunoglobulin heavy-chain	4609	238412(Tax:10090)	Gene	Gene	translocation|compound|START_ENTITY translocation|amod|END_ENTITY	In a model of immunoglobulin_heavy-chain -LRB- IGH -RRB- / MYC translocation , the Igh_3 ' regulatory region induces MYC expression at the immature stage of B cell development .
23552692	0	MYC	35,38	miR-375	17,24	MYC	miR-375	4609	494324	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions .
26517351	0	MYCBP2	44,50	c-MYC	30,35	MYCBP2	c-MYC	23077	4609	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros_dysfunction in adult acute_lymphoblastic_leukemia .
20647308	0	MYCC	54,58	p27Kip1	0,7	MYCC	p27Kip1	4609	1027	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	p27Kip1 mediates addiction of ovarian_cancer cells to MYCC -LRB- c-MYC -RRB- and their dependence on MYC paralogs .
22439933	0	MYCN	32,36	ALK	10,13	MYCN	ALK	252851(Tax:7955)	564470(Tax:7955)	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	Activated ALK collaborates with MYCN in neuroblastoma pathogenesis .
24356251	0	MYCN	9,13	ALK	0,3	MYCN	ALK	18109(Tax:10090)	11682(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma .
20190806	0	MYCN	10,14	Bmi1	0,4	MYCN	Bmi1	4613	648	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma .
17643814	0	MYCN	32,36	Dickkopf-1	0,10	MYCN	Dickkopf-1	4613	22943	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|END_ENTITY	Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation .
1656953	0	MYCN	9,13	FGF_receptor	90,102	MYCN	FGF receptor	4613	2263	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|compound|END_ENTITY	Enhanced MYCN oncogene expression in human neuroblastoma cells is associated with altered FGF_receptor expression and cellular growth response to basic FGF .
16166307	0	MYCN	49,53	High_mobility_group_A1	0,22	MYCN	High mobility group A1	4613	3159	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	High_mobility_group_A1 is a molecular target for MYCN in human neuroblastoma .
15644444	0	MYCN	67,71	MDM2	24,28	MYCN	MDM2	4613	4193	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma .
15917661	0	MYCN	35,39	MDM2	0,4	MYCN	MDM2	18109(Tax:10090)	17246(Tax:10090)	Gene	Gene	oncogene|compound|START_ENTITY effector|nmod|oncogene END_ENTITY|nmod|effector	MDM2 as a critical effector of the MYCN oncogene in tumorigenesis .
15927364	0	MYCN	8,12	MDM2	0,4	MYCN	MDM2	18109(Tax:10090)	17246(Tax:10090)	Gene	Gene	target|compound|START_ENTITY END_ENTITY|nmod|target	MDM2 as MYCN transcriptional target : implications for neuroblastoma pathogenesis .
21822304	0	MYCN	15,19	MDM2	0,4	MYCN	MDM2	4613	4193	Gene	Gene	stabilization|compound|START_ENTITY regulates|dobj|stabilization regulates|nsubj|END_ENTITY	MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells .
26035700	0	MYCN	35,39	MYC	24,27	MYCN	MYC	4613	4609	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma : a Children 's Oncology Group study .
26137098	0	MYCN	23,27	Phox2B	0,6	MYCN	Phox2B	4613	8929	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development .
23851507	0	MYCN	21,25	RUNX3	0,5	MYCN	RUNX3	4613	864	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma .
23226679	0	MYCN	23,27	SKP2	5,9	MYCN	SKP2	4613	6502	Gene	Gene	Genes|compound|START_ENTITY p53|nmod|Genes p53|nummod|END_ENTITY	p53 , SKP2 , and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance .
25843293	0	MYCN	43,47	SKP2	0,4	MYCN	SKP2	4613	6502	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma .
17652624	0	MYCN	75,79	Skp2	5,9	MYCN	Skp2	4613	6502	Gene	Gene	status|compound|START_ENTITY independent|nmod|status characterizes|xcomp|independent characterizes|nsubj|expression expression|amod|END_ENTITY	High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status .
25475555	0	MYCN	45,49	TWIST1	0,6	MYCN	TWIST1	4613	7291	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma .
25100564	0	MYCN	34,38	Trim32	0,6	MYCN	Trim32	4613	22954	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|compound|END_ENTITY	Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells .
19652553	0	MYC_antagonist_MNT	68,86	miR-210	9,16	MYC antagonist MNT	miR-210	4335	406992	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	MicroRNA miR-210 modulates cellular response to hypoxia through the MYC_antagonist_MNT .
23640900	0	MYF5	23,27	MYF5	98,102	MYF5	MYF5	281335(Tax:9913)	281335(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Enhanced expression of MYF5 and MYOD1 in fibroblast cells via the forced expression of bos_taurus MYF5 .
23640900	0	MYF5	98,102	MYF5	23,27	MYF5	MYF5	281335(Tax:9913)	281335(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Enhanced expression of MYF5 and MYOD1 in fibroblast cells via the forced expression of bos_taurus MYF5 .
20377893	0	MYG1	33,37	C12orf10	39,47	MYG1	C12orf10	60314	60314	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Promoter polymorphism -119 C/G in MYG1 -LRB- C12orf10 -RRB- gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entrance of Myg1 .
16103460	0	MYH	63,66	Cyclooxygenase-2	0,16	MYH	Cyclooxygenase-2	4595	5743	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Cyclooxygenase-2 expression in FAP patients carrying germ line MYH mutations .
22976277	0	MYH11	96,101	myosin_heavy_chain_11	73,94	MYH11	myosin heavy chain 11	24582(Tax:10116)	24582(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Estrogen-induced maldevelopment of the penis involves down-regulation of myosin_heavy_chain_11 -LRB- MYH11 -RRB- expression , a biomarker for smooth muscle cell differentiation .
7835087	0	MYH12	68,73	myosin_heavy_chain_12	45,66	MYH12	myosin heavy chain 12	4644	4644	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and regional assignment of the human myosin_heavy_chain_12 -LRB- MYH12 -RRB- gene to chromosome band 15q21 .
24059862	0	MYH14	41,46	miR-499	98,105	MYH14	miR-499	79784	102466472	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499 : muscle-specific miR-499 expression persists in the absence of the ancestral host gene .
16642020	0	MYH3	43,47	myosin	23,29	MYH3	myosin	4621	79784	Gene	Gene	chain|appos|START_ENTITY chain|amod|END_ENTITY	Mutations in embryonic myosin heavy chain -LRB- MYH3 -RRB- cause Freeman-Sheldon_syndrome and Sheldon-Hall_syndrome .
25915937	0	MYH7	91,95	miR-143	76,83	MYH7	miR-143	4625	406935	Gene	Gene	Gene|compound|START_ENTITY END_ENTITY|nmod|Gene	MicroRNA Transcriptome Profile Analysis in Porcine Muscle and the Effect of miR-143 on the MYH7 Gene and Protein .
25915937	0	MYH7	91,95	miR-143	76,83	MYH7	miR-143	4625	406935	Gene	Gene	Gene|compound|START_ENTITY END_ENTITY|nmod|Gene	MicroRNA Transcriptome Profile Analysis in Porcine Muscle and the Effect of miR-143 on the MYH7 Gene and Protein .
15699387	0	MYH7	47,51	myosin	39,45	MYH7	myosin	4625	79784	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Myosin storage myopathy : slow skeletal myosin -LRB- MYH7 -RRB- mutation in two isolated cases .
25505834	0	MYH9	9,13	DFNA17	24,30	MYH9	DFNA17	4627	4627	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	c.G2114A MYH9 mutation -LRB- DFNA17 -RRB- causes non-syndromic autosomal dominant hearing_loss in a Brazilian family .
21380797	0	MYH9	80,84	IIA	75,78	MYH9	IIA	4627	4627	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA -LRB- MYH9 protein -RRB- in human podocytes .
26152646	0	MYH9	90,94	myosin_heavy_chain_9	96,116	MYH9	myosin heavy chain 9	4627	4627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Estimated glomerular filtration rate -LRB- eGFR -RRB- , 25 -LRB- OH -RRB- _ D3 , chronic_kidney_disease -LRB- CKD -RRB- , the MYH9 -LRB- myosin_heavy_chain_9 -RRB- gene in old and very elderly people .
20523037	0	MYH9	42,46	non-muscle_Myosin_heavy_chain_9	4,35	MYH9	non-muscle Myosin heavy chain 9	4627	4627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The non-muscle_Myosin_heavy_chain_9 gene -LRB- MYH9 -RRB- is not associated with lupus_nephritis in African_Americans .
19177153	0	MYH9	59,63	non-muscle_myosin_heavy_chain_9	21,52	MYH9	non-muscle myosin heavy chain 9	4627	4627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the non-muscle_myosin_heavy_chain_9 gene -LRB- MYH9 -RRB- are strongly associated with end-stage_renal_disease historically attributed to hypertension in African Americans .
23776349	0	MYH9	95,99	non-muscle_myosin_heavy_chain_9	62,93	MYH9	non-muscle myosin heavy chain 9	4627	4627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pilot study of an association between a common variant in the non-muscle_myosin_heavy_chain_9 -LRB- MYH9 -RRB- gene and type 2 diabetic_nephropathy in a Taiwanese population .
26074085	0	MYL2	35,39	myosin_light_chain-2	13,33	MYL2	myosin light chain-2	4633	4633	Gene	Gene	Functions|appos|START_ENTITY Functions|nmod|END_ENTITY	Functions of myosin_light_chain-2 -LRB- MYL2 -RRB- in cardiac muscle and disease .
10036190	0	MYLK	101,105	myosin_light_chain_kinase	74,99	MYLK	myosin light chain kinase	4638	4638	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A genomic region encompassing a cluster of olfactory receptor genes and a myosin_light_chain_kinase -LRB- MYLK -RRB- gene is duplicated on human chromosome regions 3q13-q21 and 3p13 .
11306802	0	MYLK	42,46	myosin_light_chain_kinase	15,40	MYLK	myosin light chain kinase	4638	4638	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The functional myosin_light_chain_kinase -LRB- MYLK -RRB- gene localizes with marker D3S3552 on human chromosome 3q21 in a > 5-Mb yeast artificial chromosome region and is not linked to olfactory receptor genes .
25014165	0	MYO18A	100,106	myosin_18A	88,98	MYO18A	myosin 18A	399687	399687	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of the extreme carboxyl-terminus of PAK-interacting exchange factor b -LRB- bPIX -RRB- to myosin_18A -LRB- MYO18A -RRB- is required for epithelial cell migration .
17386922	0	MYO18B	13,19	HOMER2	0,6	MYO18B	HOMER2	84700	9455	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth .
16499872	0	MYO18B	0,6	Sug1	46,50	MYO18B	Sug1	84700	5705	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway .
24616153	0	MYO1A	57,62	DFNA48	69,75	MYO1A	DFNA48	4640	4640	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Targeted and genomewide NGS data disqualify mutations in MYO1A , the `` DFNA48 gene '' , as a cause of deafness .
23028769	0	MYOC	45,49	CYP1B1	35,41	MYOC	CYP1B1	4653	1545	Gene	Gene	upregulation|compound|START_ENTITY END_ENTITY|nmod|upregulation	Molecular basis for involvement of CYP1B1 in MYOC upregulation and its potential implication in glaucoma pathogenesis .
10320784	0	MYOC	80,84	GLC1A	86,91	MYOC	GLC1A	4653	4653	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression pattern and in situ localization of the mouse homologue of the human MYOC -LRB- GLC1A -RRB- gene in adult brain .
10617907	0	MYOC	14,18	myocilin	4,12	MYOC	myocilin	4653	4653	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The myocilin -LRB- MYOC -RRB- gene expression in the human trabecular meshwork .
11133859	0	MYOC	28,32	myocilin	18,26	MYOC	myocilin	4653	4653	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of the myocilin -LRB- MYOC -RRB- glaucoma gene in monkey and human steroid-induced ocular_hypertension .
17893664	0	MYOC	45,49	myocilin	35,43	MYOC	myocilin	4653	4653	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of mutations in the myocilin -LRB- MYOC -RRB- gene in Taiwanese patients with juvenile-onset_open-angle_glaucoma .
9446806	0	MYOC	49,53	myocilin	34,42	MYOC	myocilin	4653	4653	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the human myocilin gene -LRB- MYOC -RRB- responsible for primary open angle_glaucoma -LRB- GLC1A -RRB- .
15475516	0	MYPT1	43,48	ETA	69,72	MYPT1	ETA	4659	1909	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Gq/G13 signaling by ET-1 in smooth muscle : MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB .
19744480	0	MYPT1	14,19	SIAH2	57,62	MYPT1	SIAH2	4659	6478	Gene	Gene	stability|compound|START_ENTITY Regulation|nmod|stability Regulation|nmod|END_ENTITY	Regulation of MYPT1 stability by the E3 ubiquitin ligase SIAH2 .
18341605	0	MYT1	141,145	myelin_transcription_factor_1	105,134	MYT1	myelin transcription factor 1	4661	4661	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mental_retardation in a girl with a subtelomeric deletion on chromosome 20q and complete deletion of the myelin_transcription_factor_1 gene -LRB- MYT1 -RRB- .
17851584	0	MZF1	17,21	peptidylarginine_deiminase_type_I	71,104	MZF1	peptidylarginine deiminase type I	7593	29943	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|regulation regulation|nmod|gene gene|amod|END_ENTITY	Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine_deiminase_type_I gene -LRB- PADI1 -RRB- in human keratinocytes .
17823696	0	Mac-1	40,45	CD11b	33,38	Mac-1	CD11b	3684	3684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Increased Expression of Monocyte CD11b -LRB- Mac-1 -RRB- in Overweight Recent-Onset Type 1 Diabetic Children .
9241529	0	Mac-1	49,54	CD4	44,47	Mac-1	CD4	16409(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The appearance of unusual phenotypic cells -LRB- CD4 + Mac-1 + class II + -RRB- in the liver of -LRB- NZW x BXSB -RRB- F1 mice is possibly an animal model for autoimmune_hepatitis .
16481048	0	Mac-1	5,10	CD5	0,3	Mac-1	CD5	16409(Tax:10090)	12507(Tax:10090)	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	CD5 + / Mac-1 - peritoneal B cells : a novel B cell subset that exhibits characteristics of B-1 cells .
2456938	0	Mac-1	17,22	CD5	38,41	Mac-1	CD5	3689	921	Gene	Gene	Co-expression|nmod|START_ENTITY Co-expression|nmod|cells cells|compound|END_ENTITY	Co-expression of Mac-1 and p150 ,95 on CD5 + B cells .
21233413	0	Mac-1	80,85	Cytohesin-1	0,11	Mac-1	Cytohesin-1	3689	9267	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Cytohesin-1 regulates fMLF-mediated activation and functions of the b2 integrin Mac-1 in human neutrophils .
12952972	0	Mac-1	86,91	High_molecular_weight_kininogen	0,31	Mac-1	High molecular weight kininogen	3684	3827	Gene	Gene	Ib|compound|START_ENTITY bridging|dobj|Ib regulates|advcl|bridging regulates|nsubj|END_ENTITY	High_molecular_weight_kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib .
8034694	0	Mac-1	41,46	High_molecular_weight_kininogen	0,31	Mac-1	High molecular weight kininogen	3684	3827	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	High_molecular_weight_kininogen binds to Mac-1 on neutrophils by its heavy chain -LRB- domain 3 -RRB- and its light chain -LRB- domain 5 -RRB- .
19917697	0	Mac-1	40,45	IL-10	90,95	Mac-1	IL-10	16409(Tax:10090)	16153(Tax:10090)	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	Selective down-regulation of neutrophil Mac-1 in endotoxemic_hepatic_microcirculation via IL-10 .
26160172	0	Mac-1	0,5	IL-13	16,21	Mac-1	IL-13	16409(Tax:10090)	16163(Tax:10090)	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13Ra1 .
20416175	0	Mac-1	35,40	IL-27	1,6	Mac-1	IL-27	3689	246778	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- IL-27 regulates the expression of Mac-1 , fMLP-R and IL-1beta in human neutrophils through p38 MAPK and PI3K signal pathways -RSB- .
8566068	0	Mac-1	20,25	beta_2	4,10	Mac-1	beta 2	3689	10242	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	The beta_2 integrin Mac-1 but not p150 ,95 associates with Fc_gamma_RIIA .
10050668	0	Mac-1	87,92	eotaxin	61,68	Mac-1	eotaxin	16409(Tax:10090)	20292(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1 / ICAM-1 and VLA-4 / VCAM-1 interactions .
10845911	0	Mac-1	83,88	high_molecular_weight_kininogen	8,39	Mac-1	high molecular weight kininogen	3684	3827	Gene	Gene	CD11b/CD18|appos|START_ENTITY binds|nmod|CD11b/CD18 binds|nsubj|END_ENTITY	Cleaved high_molecular_weight_kininogen binds directly to the integrin CD11b/CD18 -LRB- Mac-1 -RRB- and blocks adhesion to fibrinogen and ICAM-1 .
2428876	0	Mac-1	28,33	p150	42,46	Mac-1	p150	3684	10036	Gene	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	Regulated expression of the Mac-1 , LFA-1 , p150 ,95 glycoprotein family during leukocyte differentiation .
2521491	1	Mac-1	156,161	p150	170,174	Mac-1	p150	3684	10036	Gene	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1 , LFA-1 , p150 ,95 glycoprotein family .
1850304	0	Mac-1	122,127	protein_kinase_C	12,28	Mac-1	protein kinase C	3684	112476	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	The role of protein_kinase_C activation and inositol_phosphate production in the regulation of cell-surface expression of Mac-1 by complement fragment C5a .
7583357	0	Mac-2-binding_protein	29,50	CD14	68,72	Mac-2-binding protein	CD14	3959	929	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	LPS-dependent interaction of Mac-2-binding_protein with immobilized CD14 .
26448934	0	Mac-2BP	31,38	Galectin-1_and_90K	12,30	Mac-2BP	Galectin-1 and 90K	3959	3956	Gene	Gene	START_ENTITY|dep|Circulating Circulating|dobj|END_ENTITY	Circulating Galectin-1_and_90K / Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal_Cancer .
11980646	0	Mac-2_BP	19,27	90K	14,17	Mac-2 BP	90K	3959	3959	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of 90K -LRB- Mac-2_BP -RRB- correlates with distant metastasis and predicts survival in stage I non-small_cell_lung_cancer patients .
18942707	0	Mac-2_BP	24,32	90K	19,22	Mac-2 BP	90K	3959	3959	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High expression of 90K -LRB- Mac-2_BP -RRB- is associated with poor survival in node-negative breast_cancer patients not receiving adjuvant systemic therapies .
21248133	0	Mac1	24,28	HMGB1	0,5	Mac1	HMGB1	3684	3146	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration .
22445756	0	Mac1p	89,94	CTR2	32,36	Mac1p	CTR2	855035(Tax:4932)	856580(Tax:4932)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Low-affinity copper transporter CTR2 is regulated by copper-sensing transcription factor Mac1p in Saccharomyces_cerevisiae .
22683637	0	Mac1p	36,41	CTR2	102,106	Mac1p	CTR2	855035(Tax:4932)	856580(Tax:4932)	Gene	Gene	factors|dep|START_ENTITY regulate|nsubj|factors regulate|dobj|END_ENTITY	Metal-sensing transcription factors Mac1p and Aft1p coordinately regulate vacuolar copper transporter CTR2 in Saccharomyces_cerevisiae .
1516135	0	MacMARCKS	0,9	MARCKS	33,39	MacMARCKS	MARCKS	100009158(Tax:9986)	100345174(Tax:9986)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	MacMARCKS , a novel member of the MARCKS family of protein_kinase_C substrates .
17292354	0	MacMARCKS	18,27	integrin_beta3	42,56	MacMARCKS	integrin beta3	65108	3690	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	The regulation of MacMARCKS expression by integrin_beta3 .
22496866	0	Macf1	51,56	Nell2	30,35	Macf1	Nell2	362587(Tax:10116)	81734(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The neuronal EGF-related gene Nell2 interacts with Macf1 and supports survival of retinal ganglion cells after optic_nerve_injury .
19935829	0	Machado-Joseph_Disease	20,42	ATXN3	49,54	Machado-Joseph Disease	ATXN3	4287	4287	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The -LRB- CAG -RRB- n tract of Machado-Joseph_Disease gene -LRB- ATXN3 -RRB- : a comparison between DNA and mRNA in patients and controls .
15233999	0	Machado-Joseph_disease	97,119	MJD	121,124	Machado-Joseph disease	MJD	110616(Tax:10090)	110616(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure , promoter activity , and developmental expression of the mouse homologue of the Machado-Joseph_disease -LRB- MJD -RRB- gene .
18166131	0	MacroH2A1	0,9	Peg3	35,39	MacroH2A1	Peg3	26914(Tax:10090)	18616(Tax:10090)	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	MacroH2A1 knockdown effects on the Peg3 imprinted domain .
26138128	0	Macrophage-Inducible_C-Type_Lectin	0,34	Spleen_Tyrosine_Kinase	35,57	Macrophage-Inducible C-Type Lectin	Spleen Tyrosine Kinase	450223(Tax:10116)	25155(Tax:10116)	Gene	Gene	START_ENTITY|dep|Contributes Contributes|compound|END_ENTITY	Macrophage-Inducible_C-Type_Lectin / Spleen_Tyrosine_Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats .
26138128	0	Macrophage-Inducible_C-Type_Lectin	0,34	Spleen_Tyrosine_Kinase	35,57	Macrophage-Inducible C-Type Lectin	Spleen Tyrosine Kinase	450223(Tax:10116)	25155(Tax:10116)	Gene	Gene	START_ENTITY|dep|Contributes Contributes|compound|END_ENTITY	Macrophage-Inducible_C-Type_Lectin / Spleen_Tyrosine_Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats .
10229864	0	Macrophage-inflammatory_protein-1alpha_receptor	0,47	CD34	98,102	Macrophage-inflammatory protein-1alpha receptor	CD34	1230	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Macrophage-inflammatory_protein-1alpha_receptor expression on normal and chronic_myeloid_leukemia CD34 + cells .
12804176	0	Macrophage-stimulating_protein	0,30	erythropoietin	47,61	Macrophage-stimulating protein	erythropoietin	15235(Tax:10090)	13856(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Macrophage-stimulating_protein cooperates with erythropoietin to induce colony_formation_and_MAP kinase activation in primary erythroid progenitor cells .
26245897	0	Macrophage_Colony_Stimulating_Factor	21,57	Insulin-like_Growth_Factor-Binding_Protein_1	95,139	Macrophage Colony Stimulating Factor	Insulin-like Growth Factor-Binding Protein 1	1435	3484	Gene	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Release Release|nmod|END_ENTITY	Glioblastoma-derived Macrophage_Colony_Stimulating_Factor -LRB- MCSF -RRB- Induces Microglial Release of Insulin-like_Growth_Factor-Binding_Protein_1 -LRB- IGFBP1 -RRB- to Promote Angiogenesis .
26245897	0	Macrophage_Colony_Stimulating_Factor	21,57	Insulin-like_Growth_Factor-Binding_Protein_1	95,139	Macrophage Colony Stimulating Factor	Insulin-like Growth Factor-Binding Protein 1	1435	3484	Gene	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Release Release|nmod|END_ENTITY	Glioblastoma-derived Macrophage_Colony_Stimulating_Factor -LRB- MCSF -RRB- Induces Microglial Release of Insulin-like_Growth_Factor-Binding_Protein_1 -LRB- IGFBP1 -RRB- to Promote Angiogenesis .
23985752	0	Macrophage_Migration_Inhibitory_Factor	46,84	MIF	86,89	Macrophage Migration Inhibitory Factor	MIF	4282	4282	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Chemokines mRNA expression in relation to the Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- mRNA and Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- mRNA expression in the microenvironment of endometrial_cancer tissue and normal endometrium : a pilot study .
24281172	0	Macrophage_Migration_Inhibitory_Factor	12,50	MIF	52,55	Macrophage Migration Inhibitory Factor	MIF	4282	4282	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- in Ultraviolet Radiation-Induced Carcinogenesis .
24826917	0	Macrophage_Migration_Inhibitory_Factor	28,66	MIF	68,71	Macrophage Migration Inhibitory Factor	MIF	4282	4282	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Hypoxia Signaling Regulates Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- Expression in Stroke .
25647395	0	Macrophage_Migration_Inhibitory_Factor	8,46	MIF	48,51	Macrophage Migration Inhibitory Factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Macrophage_Migration_Inhibitory_Factor -LRB- MIF -RRB- in Pollen-Induced Allergic_Conjunctivitis and Pollen Dermatitis in Mice .
25677604	0	Macrophage_Migration_Inhibitory_Factor	106,144	Tissue_Factor_Pathway_Inhibitor	20,51	Macrophage Migration Inhibitory Factor	Tissue Factor Pathway Inhibitor	4282	7035	Gene	Gene	Secretion|nmod|START_ENTITY END_ENTITY|nmod|Secretion	Expression of Human Tissue_Factor_Pathway_Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage_Migration_Inhibitory_Factor and Attenuates_Atherosclerosis in ApoE - / - Mice .
7634342	0	Macrophage_colony-stimulating_factor	0,36	M-CSF	38,43	Macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- induction of enhanced anticryptococcal activity in human monocyte-derived macrophages : synergy with fluconazole for killing .
24882100	0	Macrophage_colony-stimulating_factor	0,36	prolactin	45,54	Macrophage colony-stimulating factor	prolactin	78965(Tax:10116)	24683(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Macrophage_colony-stimulating_factor induces prolactin expression in rat pituitary gland .
14966426	0	Macrophage_colony-stimulating_factor	0,36	tumor_necrosis_factor	46,67	Macrophage colony-stimulating factor	tumor necrosis factor	12977(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Macrophage_colony-stimulating_factor inhibits tumor_necrosis_factor production and prolongs skin graft survival .
1334462	0	Macrophage_colony_stimulating_factor	0,36	phospholipase_A2	93,109	Macrophage colony stimulating factor	phospholipase A2	1435	151056	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Macrophage_colony_stimulating_factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase_A2 .
17549607	0	Macrophage_inflammatory_protein-1alpha	0,38	RANKL	115,120	Macrophage inflammatory protein-1alpha	RANKL	20302(Tax:10090)	21943(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|appos|END_ENTITY	Macrophage_inflammatory_protein-1alpha -LRB- MIP-1alpha -RRB- enhances a receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways .
17549607	0	Macrophage_inflammatory_protein-1alpha	0,38	receptor_activator_of_nuclear_factor_kappaB_ligand	63,113	Macrophage inflammatory protein-1alpha	receptor activator of nuclear factor kappaB ligand	20302(Tax:10090)	21943(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Macrophage_inflammatory_protein-1alpha -LRB- MIP-1alpha -RRB- enhances a receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways .
11580144	0	Macrophage_inflammatory_protein-2	0,33	TNF-alpha	45,54	Macrophage inflammatory protein-2	TNF-alpha	20310(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Macrophage_inflammatory_protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver_injury in mice .
10528169	0	Macrophage_inflammatory_protein-3_beta	0,38	IL-10	48,53	Macrophage inflammatory protein-3 beta	IL-10	6363	3586	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Macrophage_inflammatory_protein-3_beta enhances IL-10 production by activated human peripheral blood monocytes and T cells .
20872800	0	Macrophage_migration_inhibitory_factor	0,38	IL-8	81,85	Macrophage migration inhibitory factor	IL-8	4282	3576	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Macrophage_migration_inhibitory_factor contributes angiogenesis by up-regulating IL-8 and correlates with poor prognosis of patients with primary nasopharyngeal_carcinoma .
26455966	0	Macrophage_migration_inhibitory_factor	0,38	MEF2	96,100	Macrophage migration inhibitory factor	MEF2	17319(Tax:10090)	17260(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Macrophage_migration_inhibitory_factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes .
12445161	0	Macrophage_migration_inhibitory_factor	0,38	MIF	40,43	Macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in human glioblastomas correlates with vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
17728788	0	Macrophage_migration_inhibitory_factor	0,38	MIF	40,43	Macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene polymorphisms are associated with increased_prostate_cancer incidence .
21773885	0	Macrophage_migration_inhibitory_factor	0,38	MIF	40,43	Macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in human malignant_gliomas contributes to immune escape and tumour progression .
24951298	0	Macrophage_migration_inhibitory_factor	0,38	MIF	40,43	Macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- -173 polymorphism is associated with clinical erythema_nodosum in L __ fgren 's _ syndrome .
10880236	0	Macrophage_migration_inhibitory_factor	0,38	MMP-2	49,54	Macrophage migration inhibitory factor	MMP-2	4282	4313	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Macrophage_migration_inhibitory_factor increases MMP-2 activity in DU-145 prostate cells .
15585220	0	Macrophage_migration_inhibitory_factor	0,38	MMP-9	47,52	Macrophage migration inhibitory factor	MMP-9	4282	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Macrophage_migration_inhibitory_factor induces MMP-9 expression : implications for destabilization of human atherosclerotic_plaques .
17316137	0	Macrophage_migration_inhibitory_factor	0,38	MMP-9	47,52	Macrophage migration inhibitory factor	MMP-9	17319(Tax:10090)	17395(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Macrophage_migration_inhibitory_factor induces MMP-9 expression in macrophages via the MEK-ERK MAP kinase pathway .
18490733	0	Macrophage_migration_inhibitory_factor	0,38	NKG2D	109,114	Macrophage migration inhibitory factor	NKG2D	4282	22914	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Macrophage_migration_inhibitory_factor contributes to the immune escape of ovarian_cancer by down-regulating NKG2D .
12803886	0	Macrophage_migration_inhibitory_factor	0,38	Toll-like_receptor_4	105,125	Macrophage migration inhibitory factor	Toll-like receptor 4	4282	7099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|endotoxin endotoxin|nmod|modulation modulation|nmod|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- regulates host responses to endotoxin through modulation of Toll-like_receptor_4 -LRB- TLR4 -RRB- .
23411097	0	Macrophage_migration_inhibitory_factor	0,38	Toll-like_receptor_4	115,135	Macrophage migration inhibitory factor	Toll-like receptor 4	4282	7099	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|modulation modulation|nmod|END_ENTITY	Macrophage_migration_inhibitory_factor is necessary for the lipo-oligosaccharide-induced response by modulation of Toll-like_receptor_4 in monocytes from GBS patients .
14736878	0	Macrophage_migration_inhibitory_factor	0,38	thrombin	53,61	Macrophage migration inhibitory factor	thrombin	4282	2147	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Macrophage_migration_inhibitory_factor is induced by thrombin and factor_Xa in endothelial cells .
26813112	0	Macrophage_migration_inhibitory_factor	0,38	toll-like_receptor_4	112,132	Macrophage migration inhibitory factor	toll-like receptor 4	4282	7099	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|inducing inducing|xcomp|END_ENTITY	Macrophage_migration_inhibitory_factor enhances lipopolysaccharide-induced fibroblast proliferation by inducing toll-like_receptor_4 .
16423395	0	Mad1	0,4	Bcl-6	39,44	Mad1	Bcl-6	17119(Tax:10090)	12053(Tax:10090)	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Mad1 is a transcriptional repressor of Bcl-6 .
11707408	0	Mad1	16,20	Mad2	0,4	Mad1	Mad2	779097(Tax:8355)	399442(Tax:8355)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Mad2 binding to Mad1 and Cdc20 , rather than oligomerization , is required for the spindle checkpoint .
18981471	0	Mad1	22,26	Tpr	0,3	Mad1	Tpr	4084	7175	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint .
15611654	0	Mad1	87,91	Trf1	36,40	Mad1	Trf1	17120(Tax:10090)	21749(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The telomere repeat binding protein Trf1 interacts with the spindle checkpoint protein Mad1 and Nek2 mitotic kinase .
23459071	0	Mad1	0,4	doxorubicin_resistance	30,52	Mad1	doxorubicin resistance	4084	5243	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Mad1 mediates hypoxia-induced doxorubicin_resistance in colon_cancer cells by inhibiting mitochondrial function .
19139260	0	Mad1p	40,45	Xpo1p	26,31	Mad1p	Xpo1p	852794(Tax:4932)	853133(Tax:4932)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast .
11907259	0	Mad2	51,55	BubR1	19,24	Mad2	BubR1	4085	701	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting_complex .
21149564	0	Mad2	0,4	MKlp2	34,39	Mad2	MKlp2	4085	10112	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Mad2 inhibits the mitotic kinesin MKlp2 .
11707408	0	Mad2	0,4	Mad1	16,20	Mad2	Mad1	399442(Tax:8355)	779097(Tax:8355)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Mad2 binding to Mad1 and Cdc20 , rather than oligomerization , is required for the spindle checkpoint .
17038523	0	Mad2	44,48	c-Kit	65,70	Mad2	c-Kit	4085	3815	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Mad2 is required for optimal hematopoiesis : Mad2 associates with c-Kit in MO7e cells .
11159190	0	Madh4	30,35	Dpc4	24,28	Madh4	Dpc4	4089	4089	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of Dpc4 -LRB- Madh4 , Smad4 -RRB- in colorectal_carcinomas and relation to mismatch repair/transforming growth factor-beta receptor defects .
20149264	0	Madm	0,4	Bunched_A	45,54	Madm	Bunched A	40710(Tax:7227)	34665(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Madm -LRB- Mlf1_adapter_molecule -RRB- cooperates with Bunched_A to promote growth in Drosophila .
7891713	0	Maf	6,9	Fos	39,42	Maf	Fos	4094	2353	Gene	Gene	proteins|compound|START_ENTITY heterodimerize|nsubj|proteins heterodimerize|nmod|END_ENTITY	Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor .
8108109	0	Maf	0,3	Fos	62,65	Maf	nrl	4094	4901	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. .
8552399	0	Maf	28,31	Fos	73,76	Maf	Fos	17132(Tax:10090)	14281(Tax:10090)	Gene	Gene	oncoprotein|compound|START_ENTITY activity|nmod|oncoprotein modulated|nsubjpass|activity modulated|nmod|proteins proteins|compound|END_ENTITY	Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins .
8552399	0	Maf	87,90	Fos	73,76	Maf	Fos	17132(Tax:10090)	14281(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins .
8552399	0	Maf	28,31	Maf	87,90	Maf	Maf	17132(Tax:10090)	17132(Tax:10090)	Gene	Gene	oncoprotein|compound|START_ENTITY activity|nmod|oncoprotein modulated|nsubjpass|activity modulated|nmod|proteins proteins|compound|END_ENTITY	Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins .
8552399	0	Maf	87,90	Maf	28,31	Maf	Maf	17132(Tax:10090)	17132(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY modulated|nmod|proteins modulated|nsubjpass|activity activity|nmod|oncoprotein oncoprotein|compound|END_ENTITY	Transactivation activity of Maf nuclear oncoprotein is modulated by Jun , Fos and small Maf proteins .
27058431	0	Maf	6,9	MafF	20,24	Maf	MafF	17132(Tax:10090)	17133(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Small Maf proteins -LRB- MafF , MafG , MafK -RRB- : History , structure and function .
10747965	0	Maf	0,3	p53	42,45	Maf	p53	17132(Tax:10090)	22060(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death .
25502566	0	Maf1	0,4	PTEN	26,30	Maf1	PTEN	68877(Tax:10090)	19211(Tax:10090)	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism .
25785728	0	Maf1	12,16	PTEN	38,42	Maf1	PTEN	84232	5728	Gene	Gene	Is|nsubj|START_ENTITY Is|xcomp|Oncogenesis Oncogenesis|nsubj|Target Target|nmod|Signaling Signaling|compound|END_ENTITY	Correction : Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism .
23736775	0	MafA	89,93	CD34	97,101	MafA	CD34	389692	947	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	A Short-activating RNA Oligonucleotide Targeting the Islet b-cell Transcriptional Factor MafA in CD34 -LRB- + -RRB- Cells .
21193557	0	MafA	40,44	Hnf1a	0,5	MafA	Hnf1a	389692	6927	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hnf1a -LRB- MODY3 -RRB- regulates b-cell-enriched MafA transcription factor expression .
16580660	0	MafA	22,26	MafB	14,18	MafA	MafB	378435(Tax:10090)	16658(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells .
22733810	0	MafA	50,54	MicroRNA-30d	0,12	MafA	MicroRNA-30d	378435(Tax:10090)	387228(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated_protein_4_kinase_4 -LRB- MAP4K4 -RRB- in pancreatic b-cells .
18522939	0	MafA	0,4	Pdx1	23,27	MafA	Pdx1	378435(Tax:10090)	18609(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells .
12011435	0	MafA	92,96	insulin	37,44	MafA	insulin	389692	3630	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Identification Identification|nmod|gene gene|compound|END_ENTITY	Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA .
12368292	0	MafA	0,4	insulin	96,103	MafA	insulin	389692	3630	Gene	Gene	activator|nsubj|START_ENTITY activator|nmod|gene gene|compound|END_ENTITY	MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene .
14973194	0	MafA	4,8	insulin	90,97	MafA	insulin	389692	3630	Gene	Gene	factor|compound|START_ENTITY appears|nsubj|factor appears|xcomp|responsible responsible|nmod|expression expression|nmod|END_ENTITY	The MafA transcription factor appears to be responsible for tissue-specific expression of insulin .
15664999	0	MafA	54,58	insulin	106,113	MafA	insulin	389692	3630	Gene	Gene	protein|compound|START_ENTITY loss|nmod|protein Oxidative|dobj|loss Oxidative|nmod|mechanism mechanism|nmod|loss loss|nmod|expression expression|compound|END_ENTITY	Oxidative stress-mediated , post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells .
15993959	0	MafA	100,104	insulin	30,37	MafA	insulin	389692	3630	Gene	Gene	enriched|xcomp|START_ENTITY enriched|nsubj|activation activation|nmod|promoter promoter|compound|END_ENTITY	Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA , Beta2 , and Pdx1 .
18515495	0	MafA	0,4	insulin	37,44	MafA	insulin	395881(Tax:9031)	396145(Tax:9031)	Gene	Gene	activator|nsubj|START_ENTITY activator|nmod|gene gene|compound|END_ENTITY	MafA is a dedicated activator of the insulin gene in vivo .
20682694	0	MafA	23,27	insulin	64,71	MafA	insulin	389692	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes .
21857924	0	MafA	29,33	insulin	82,89	MafA	insulin	389692	3630	Gene	Gene	protein|compound|START_ENTITY transduction|nmod|protein transduction|nmod|results results|nmod|expression expression|compound|END_ENTITY	TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphology .
14680841	0	MafA	6,10	somite_Maf_1	35,47	MafA	somite Maf 1	114467(Tax:7955)	100000492(Tax:7955)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Mouse MafA , homologue of zebrafish somite_Maf_1 , contributes to the specific transcriptional activity through the insulin promoter .
21713993	0	MafB	0,4	Gcm2	20,24	MafB	Gcm2	16658(Tax:10090)	107889(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MafB interacts with Gcm2 and regulates parathyroid_hormone expression and parathyroid development .
16580660	0	MafB	14,18	MafA	22,26	MafB	MafA	16658(Tax:10090)	378435(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells .
24472656	0	MafB	0,4	STAT3	41,46	MafB	STAT3	9935	6774	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	MafB is a downstream target of the IL-10 / STAT3 signaling pathway , involved in the regulation of macrophage de-activation .
27058431	0	MafF	20,24	Maf	6,9	MafF	Maf	17133(Tax:10090)	17132(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Small Maf proteins -LRB- MafF , MafG , MafK -RRB- : History , structure and function .
26501563	0	MafG	0,4	FXR	24,27	MafG	FXR	4097	9971	Gene	Gene	START_ENTITY|appos|Target Target|nmod|END_ENTITY	MafG , A Novel Target of FXR that Regulates Bile_Acid Homeostasis .
11013233	0	MafG	11,15	maf	6,9	MafG	maf	4097	4094	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Small maf -LRB- MafG and MafK -RRB- proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD -LRB- P -RRB- H : Quinone_oxidoreductase1 gene .
20233453	0	MafK	32,36	Akt	0,3	MafK	Akt	246760(Tax:10116)	24185(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Akt regulates the expression of MafK , synaptotagmin_I , and syntenin-1 , which play roles_in_neuronal_function .
10747902	1	MafK	101,105	Nrf2	78,82	MafK	Nrf2	7975	4780	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation by Nrf2 and repression by MafK .
26358767	0	MagT1	41,46	Magnesium_Transporter_Subtype_1	8,39	MagT1	Magnesium Transporter Subtype 1	116967(Tax:10116)	116967(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Magnesium_Transporter_Subtype_1 -LRB- MagT1 -RRB- in the Osteogenic Differentiation of Rat Bone Marrow Stem Cells .
26358767	0	Magnesium_Transporter_Subtype_1	8,39	MagT1	41,46	Magnesium Transporter Subtype 1	MagT1	116967(Tax:10116)	116967(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Magnesium_Transporter_Subtype_1 -LRB- MagT1 -RRB- in the Osteogenic Differentiation of Rat Bone Marrow Stem Cells .
7669668	0	Major_basic_protein	0,19	thrombomodulin	31,45	Major basic protein	thrombomodulin	4155	7056	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Major_basic_protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia .
25843798	0	Major_urinary_protein_1	0,23	cannabinoid_receptor_type_1	39,66	Major urinary protein 1	cannabinoid receptor type 1	17840(Tax:10090)	12801(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Major_urinary_protein_1 interacts with cannabinoid_receptor_type_1 in fatty_acid-induced hepatic insulin resistance in a mouse hepatocyte model .
25843798	0	Major_urinary_protein_1	0,23	cannabinoid_receptor_type_1	39,66	Major urinary protein 1	cannabinoid receptor type 1	17840(Tax:10090)	12801(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Major_urinary_protein_1 interacts with cannabinoid_receptor_type_1 in fatty_acid-induced hepatic insulin resistance in a mouse hepatocyte model .
22485159	0	Mal	72,75	TLR4	79,83	Mal	TLR4	4118	7099	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling .
25868726	0	Malat1	0,6	serum_response_factor	17,38	Malat1	serum response factor	72289(Tax:10090)	20807(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Malat1 regulates serum_response_factor through miR-133 as a competing endogenous RNA in myogenesis .
11716464	0	Malonyl-CoA_decarboxylase	0,25	AMP-activated_protein_kinase	48,76	Malonyl-CoA decarboxylase	AMP-activated protein kinase	85239(Tax:10116)	78975(Tax:10116)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Malonyl-CoA_decarboxylase is not a substrate of AMP-activated_protein_kinase in rat fast-twitch skeletal muscle or an islet cell line .
21283787	0	Malt1	31,36	C-Rel	10,15	Malt1	C-Rel	10892	5966	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Selective C-Rel activation via Malt1 controls anti-fungal T -LRB- H -RRB- -17 immunity by dectin-1 and dectin-2 .
15019995	0	Maml1	73,78	mastermind-like_1	54,71	Maml1	mastermind-like 1	103806(Tax:10090)	103806(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and functional characterization of the murine mastermind-like_1 -LRB- Maml1 -RRB- gene .
26023239	0	Mammalian_Target_of_Rapamycin	60,89	PI3K	53,57	Mammalian Target of Rapamycin	PI3K	2475	5293	Gene	Gene	mTOR|compound|START_ENTITY mTOR|dep|Signaling Signaling|nmod|Phosphatidylinositol_3-Kinase Phosphatidylinositol_3-Kinase|appos|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26023239	0	Mammalian_Target_of_Rapamycin	60,89	PI3K	53,57	Mammalian Target of Rapamycin	PI3K	2475	5293	Gene	Gene	mTOR|compound|START_ENTITY mTOR|dep|Signaling Signaling|nmod|Phosphatidylinositol_3-Kinase Phosphatidylinositol_3-Kinase|appos|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26101222	0	Mammalian_Target_of_Rapamycin	56,85	PI3K	50,54	Mammalian Target of Rapamycin	PI3K	2475	5293	Gene	Gene	Sensitizes|nsubj|START_ENTITY Inhibition|parataxis|Sensitizes Inhibition|nmod|Phosphoinositide_3-Kinase Phosphoinositide_3-Kinase|appos|END_ENTITY	Targeted Inhibition of Phosphoinositide_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Sensitizes Pancreatic_Cancer Cells to Doxorubicin without Exacerbating Cardiac_Toxicity .
26101222	0	Mammalian_Target_of_Rapamycin	56,85	Phosphoinositide_3-Kinase	23,48	Mammalian Target of Rapamycin	Phosphoinositide 3-Kinase	2475	5293	Gene	Gene	Sensitizes|nsubj|START_ENTITY Inhibition|parataxis|Sensitizes Inhibition|nmod|END_ENTITY	Targeted Inhibition of Phosphoinositide_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Sensitizes Pancreatic_Cancer Cells to Doxorubicin without Exacerbating Cardiac_Toxicity .
26176550	0	Mammalian_Target_of_Rapamycin	39,68	Rictor	87,93	Mammalian Target of Rapamycin	Rictor	2475	253260	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	Defining the Domain Arrangement of the Mammalian_Target_of_Rapamycin Complex Component Rictor Protein .
20419051	0	Mammalian_Target_of_Rapamycin	72,101	mTOR	103,107	Mammalian Target of Rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|appos|END_ENTITY	Developing Antiepileptogenic Drugs for Acquired Epilepsy : Targeting the Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Pathway .
23434669	0	Mammalian_Target_of_Rapamycin	56,85	mTOR	87,91	Mammalian Target of Rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|appos|END_ENTITY	Chemical Inhibitors and microRNAs -LRB- miRNA -RRB- Targeting the Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Pathway : Potential for Novel Anticancer Therapeutics .
26083478	0	Mammalian_Target_of_Rapamycin	13,42	mTOR	44,48	Mammalian Target of Rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Kinase Inhibitor CC-223 .
23832697	0	Mammalian_enabled	26,43	Mena	45,49	Mammalian enabled	Mena	55740	55740	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Cardiac overexpression of Mammalian_enabled -LRB- Mena -RRB- exacerbates heart_failure in mice .
12105226	0	Mammalian_suppressor_of_Sec4	0,28	Rab15	64,69	Mammalian suppressor of Sec4	Rab15	5877	376267	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	Mammalian_suppressor_of_Sec4 modulates the inhibitory effect of Rab15 during early endocytosis .
17878402	0	Mammalian_target_of_rapamycin	0,29	Akt	88,91	Mammalian target of rapamycin	Akt	2475	207	Gene	Gene	inhibition|amod|START_ENTITY activates|nsubj|inhibition activates|dobj|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition activates phosphatidylinositol_3-kinase / Akt by up-regulating insulin-like_growth_factor-1 receptor signaling in acute_myeloid_leukemia : rationale for therapeutic inhibition of both pathways .
23626014	0	Mammalian_target_of_rapamycin	0,29	IL-10	40,45	Mammalian target of rapamycin	IL-10	2475	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Mammalian_target_of_rapamycin regulates IL-10 and resistance to Pseudomonas_aeruginosa corneal_infection .
16772532	0	Mammalian_target_of_rapamycin	0,29	Id2	183,186	Mammalian target of rapamycin	Id2	2475	3398	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Mammalian_target_of_rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional differentiation through Id2 .
15805247	0	Mammalian_target_of_rapamycin	60,89	androgen_receptor	39,56	Mammalian target of rapamycin	androgen receptor	2475	367	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Post-transcriptional regulation of the androgen_receptor by Mammalian_target_of_rapamycin .
21239045	0	Mammalian_target_of_rapamycin	0,29	b-catenin	54,63	Mammalian target of rapamycin	b-catenin	2475	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Mammalian_target_of_rapamycin regulates expression of b-catenin in hepatocellular_carcinoma .
15621776	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in chronic lymphocytic_B-cell_leukemia : a new therapeutic option .
17878402	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition activates phosphatidylinositol_3-kinase / Akt by up-regulating insulin-like_growth_factor-1 receptor signaling in acute_myeloid_leukemia : rationale for therapeutic inhibition of both pathways .
19346248	0	Mammalian_target_of_rapamycin	0,29	mTOR	106,110	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY associated|nsubjpass|complex associated|nmod|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity is associated with phosphorylation of raptor by mTOR .
20615870	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- activation increases axonal growth capacity of injured peripheral nerves .
22544534	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition : potential for antiseizure , antiepileptogenic , and epileptostatic therapy .
23573198	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- activity dependent phospho-protein expression in childhood acute_lymphoblastic_leukemia -LRB- ALL -RRB- .
23819792	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition does not prevent lung_adenocarcinoma-induced malignant_pleural_effusion .
24053120	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	non-infectious_pneumonitis|compound|START_ENTITY non-infectious_pneumonitis|compound|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor-associated non-infectious_pneumonitis in patients with renal_cell_cancer : predictors , management , and outcomes .
24371138	0	Mammalian_target_of_rapamycin	0,29	mTOR	31,35	Mammalian target of rapamycin	mTOR	56717(Tax:10090)	21977(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with rapamycin improves cardiac function in type 2 diabetic mice : potential role of attenuated oxidative stress and altered contractile protein expression .
26957088	0	Mammalian_target_of_rapamycin	0,29	mTOR	39,43	Mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Mammalian_target_of_rapamycin complex -LRB- mTOR -RRB- pathway modulates blood-testis barrier -LRB- BTB -RRB- function through F-actin organization and gap junction .
19346248	0	Mammalian_target_of_rapamycin	0,29	mTORC1	41,47	Mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY associated|nsubjpass|complex associated|dep|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity is associated with phosphorylation of raptor by mTOR .
22810227	0	Mammalian_target_of_rapamycin	0,29	mTORC1	41,47	Mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- and 2 -LRB- mTORC2 -RRB- control the dendritic arbor morphology of hippocampal neurons .
23278901	0	Mammalian_target_of_rapamycin	0,29	mTORC1	41,47	Mammalian target of rapamycin	mTORC1	56717(Tax:10090)	382056(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- may modulate the timing of anagen entry in mouse hair follicles .
24270265	0	Mammalian_target_of_rapamycin	0,29	mTORC2	41,47	Mammalian target of rapamycin	mTORC2	2475	74343(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Mammalian_target_of_rapamycin complex 2 -LRB- mTORC2 -RRB- coordinates pulmonary artery smooth muscle cell metabolism , proliferation , and survival in pulmonary_arterial_hypertension .
10567225	0	Mammalian_target_of_rapamycin	0,29	protein_kinase_B	53,69	Mammalian target of rapamycin	protein kinase B	2475	2185	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Mammalian_target_of_rapamycin is a direct target for protein_kinase_B : identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation .
16049006	0	Mammary_serine_protease_inhibitor	0,33	interferon_regulatory_factor_6	61,91	Mammary serine protease inhibitor	interferon regulatory factor 6	5268	3664	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Mammary_serine_protease_inhibitor -LRB- Maspin -RRB- binds directly to interferon_regulatory_factor_6 : identification of a novel serpin partnership .
25766656	0	Manganese_Superoxide_Dismutase	21,51	AMP-Activated_Protein_Kinase	75,103	Manganese Superoxide Dismutase	AMP-Activated Protein Kinase	6648	5563	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Pathway Pathway|compound|END_ENTITY	Bavachalcone-Induced Manganese_Superoxide_Dismutase Expression through the AMP-Activated_Protein_Kinase Pathway in Human Endothelial Cells .
1904900	0	Manganese_superoxide_dismutase	0,30	IFN-gamma	45,54	Manganese superoxide dismutase	IFN-gamma	6648	3458	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Manganese_superoxide_dismutase is induced by IFN-gamma in multiple cell types .
9848095	0	Manganese_superoxide_dismutase	0,30	MPTP	57,61	Manganese superoxide dismutase	MPTP	20656(Tax:10090)	19255(Tax:10090)	Gene	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Manganese_superoxide_dismutase overexpression attenuates MPTP toxicity .
12948282	0	Manganese_superoxide_dismutase	0,30	MnSOD	32,37	Manganese superoxide dismutase	MnSOD	6648	6648	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD -RRB- polymorphism , alpha-tocopherol supplementation and prostate_cancer risk in the alpha-tocopherol , beta-carotene cancer prevention study -LRB- Finland -RRB- .
17217237	0	Manganese_superoxide_dismutase	1,31	MnSOD	38,43	Manganese superoxide dismutase	MnSOD	6648	6648	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Manganese_superoxide_dismutase gene -LRB- MnSOD -RRB- polimorphism in schizophrenics with tardive_dyskinesia from central Poland -RSB- .
17582511	0	Manganese_superoxide_dismutase	0,30	MnSOD	32,37	Manganese superoxide dismutase	MnSOD	6648	6648	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD : Ala-9Val -RRB- gene polymorphism may not be associated with schizophrenia and tardive_dyskinesia .
18646267	0	Manganese_superoxide_dismutase	0,30	MnSOD	32,37	Manganese superoxide dismutase	MnSOD	6648	6648	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD -RRB- genetic polymorphism is associated with risk of early-onset prostate_cancer .
20357718	0	Manganese_superoxide_dismutase	0,30	MnSOD	32,37	Manganese superoxide dismutase	MnSOD	6648	6648	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD -RRB- gene -LRB- Ala-9Val , Ile58Thr -RRB- polymorphism in patients with age-related_macular_degeneration -LRB- AMD -RRB- .
11607788	0	Mannan-binding_lectin	0,21	MBL	23,26	Mannan-binding lectin	MBL	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mannan-binding_lectin -LRB- MBL -RRB- gene polymorphisms in ulcerative_colitis and Crohn 's _ disease .
18368489	0	Mannan-binding_lectin	0,21	MBL	23,26	Mannan-binding lectin	MBL	4153	4153	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Mannan-binding_lectin -LRB- MBL -RRB- polymorphism and gastric_cancer risk in Japanese population .
20499118	0	Mannose-binding_lectin	0,22	MBL-2	29,34	Mannose-binding lectin	MBL-2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mannose-binding_lectin gene -LRB- MBL-2 -RRB- polymorphism in oral_lichen_planus .
22347229	0	Mannose_Binding_Protein	43,66	MBP	68,71	Mannose Binding Protein	MBP	4155	4155	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Molecular Identification and Sequencing of Mannose_Binding_Protein -LRB- MBP -RRB- Gene of Acanthamoeba palestinensis .
21510992	0	Mannose_binding_lectin	0,22	MBL2	29,33	Mannose binding lectin	MBL2	4153	4153	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mannose_binding_lectin gene -LRB- MBL2 -RRB- functional polymorphisms are associated with systemic_lupus_erythematosus in southern Brazilians .
25788676	0	Map1a	52,57	microtubule-associated_protein_1A	17,50	Map1a	microtubule-associated protein 1A	17754(Tax:10090)	17754(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the microtubule-associated_protein_1A -LRB- Map1a -RRB- gene cause Purkinje cell degeneration .
15867147	0	Mapk9	24,29	Jnk2	18,22	Mapk9	Jnk2	26420(Tax:10090)	26420(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disruption of the Jnk2 -LRB- Mapk9 -RRB- gene reduces destructive insulitis and diabetes in a mouse model of type_I_diabetes .
22069323	0	Mas-related_gene_X2	0,19	LL-37	96,101	Mas-related gene X2	LL-37	117194	820	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Mas-related_gene_X2 -LRB- MrgX2 -RRB- is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells : resistance to receptor phosphorylation , desensitization , and internalization .
12917334	0	Mash-2	99,105	USF1	0,4	Mash-2	USF1	430	7391	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia .
8090202	0	Mash-2	18,24	extraembryonic_development	28,54	Mash-2	extraembryonic development	17173(Tax:10090)	70790(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role of Mash-2 in extraembryonic_development .
18585058	0	Mash1	7,12	Ascl1	0,5	Mash1	Ascl1	429	429	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Ascl1 -LRB- Mash1 -RRB- lineage cells contribute to discrete cell populations in CNS architecture .
16020526	0	Mash1	32,37	Foxn4	0,5	Mash1	Foxn4	429	121643	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord .
16503349	0	Mash2	91,96	mammalian_achaete_scute-like_homologue_2	49,89	Mash2	mammalian achaete scute-like homologue 2	430	430	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the placenta specific bovine mammalian_achaete_scute-like_homologue_2 -LRB- Mash2 -RRB- gene .
16107707	0	Maskin	38,44	eukaryotic_translation_initiation_factor_4E	62,105	Maskin	eukaryotic translation initiation factor 4E	398145(Tax:8355)	734259(Tax:8355)	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Differential phosphorylation controls Maskin association with eukaryotic_translation_initiation_factor_4E and localization on the mitotic apparatus .
14534696	0	Maspin	0,6	p53	48,51	Maspin	p53	5268	7157	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|outcome outcome|compound|END_ENTITY	Maspin in thyroid_cancer : its relationship with p53 and clinical outcome .
17174141	0	Maspin	0,6	p53	92,95	Maspin	p53	5268	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Maspin expression in early oral_tongue_cancer and its relation to expression of mutant-type p53 and vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
17700520	0	Maspin	32,38	p53	81,84	Maspin	p53	20724(Tax:10090)	22060(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY transcription|nmod|genes controls|dobj|transcription controls|nmod|END_ENTITY	ATF-2 controls transcription of Maspin and GADD45_alpha genes independently from p53 to suppress mammary_tumors .
18091325	0	Maspin	0,6	p53	18,21	Maspin	p53	5268	7157	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Maspin and Mutant p53 expression in malignant_melanoma_and_carcinoma : use of tissue_microarray .
21503001	0	Maspin	8,14	p53	67,70	Maspin	p53	5268	7157	Gene	Gene	Expression|compound|START_ENTITY Loss|nmod|Expression Loss|dep|Relationship Relationship|nmod|END_ENTITY	Loss of Maspin Expression in Bladder_Cancer : Its Relationship with p53 and Clinicopathological Parameters .
7520725	0	Mast_cell_growth_factor	0,23	granulocyte-macrophage_colony-stimulating_factor	59,107	Mast cell growth factor	granulocyte-macrophage colony-stimulating factor	17311(Tax:10090)	12981(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Mast_cell_growth_factor -LRB- C-kit_ligand -RRB- in combination with granulocyte-macrophage_colony-stimulating_factor and interleukin-3 : in vivo hemopoietic effects in irradiated mice compared to in vitro effects .
15976326	0	Mast_cell_tryptase	0,18	MCP-1	50,55	Mast cell tryptase	MCP-1	25823	6347	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Mast_cell_tryptase in mast cell granules enhances MCP-1 and interleukin-8 production in human endothelial cells .
12376559	0	Mat1	28,32	TFIIH	44,49	Mat1	TFIIH	4331	2965	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription .
16831200	0	Math1	112,117	Cdx2	37,41	Math1	Cdx2	474	1045	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The intestine-specific_homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1 .
16230531	0	Math1	29,34	Gfi1	0,4	Math1	Gfi1	11921(Tax:10090)	14581(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation .
17878293	0	Math1	34,39	Tcf4	14,18	Math1	Tcf4	474	6925	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors .
20808762	0	Math5	30,35	Atoh7	23,28	Math5	Atoh7	53404(Tax:10090)	53404(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	A critical analysis of Atoh7 -LRB- Math5 -RRB- mRNA splicing in the developing mouse retina .
19208436	0	Math5	19,24	Pax6	0,4	Math5	Pax6	53404(Tax:10090)	18508(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Pax6 regulation of Math5 during mouse retinal neurogenesis .
11852232	0	Matn2	51,56	matrilin-2	72,82	Matn2	matrilin-2	4147	4147	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Comparative analysis of the mouse and human genes -LRB- Matn2 and MATN2 -RRB- for matrilin-2 , a filament-forming protein widely distributed in extracellular matrices .
10656920	0	Matn3	52,57	matrilin-3	35,45	Matn3	matrilin-3	17182(Tax:10090)	17182(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and mapping of the mouse matrilin-3 gene -LRB- Matn3 -RRB- , a member of a gene family containing a U12-type AT-AC intron .
24959676	0	Matrilin-2	0,10	ADAMTS-4	41,49	Matrilin-2	ADAMTS-4	4147	9507	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5 .
22967398	0	Matrilin-3	0,10	IL-1_receptor_antagonist	24,48	Matrilin-3	IL-1 receptor antagonist	4148	3557	Gene	Gene	Induction|compound|START_ENTITY Induction|nmod|END_ENTITY	Matrilin-3 Induction of IL-1_receptor_antagonist Is required for up-regulating collagen II and aggrecan and down-regulating ADAMTS-5 gene expression .
16983341	0	Matriptase	0,10	hepatocyte_growth_factor_activator_inhibitor-1	25,71	Matriptase	hepatocyte growth factor activator inhibitor-1	19143(Tax:10090)	20732(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Matriptase inhibition by hepatocyte_growth_factor_activator_inhibitor-1 is essential for placental development .
23649491	0	Matriptase-2	0,12	TMPRSS6	19,26	Matriptase-2	TMPRSS6	164656	164656	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Matriptase-2 gene -LRB- TMPRSS6 -RRB- variants associate with breast_cancer survival , and reduced expression is related to triple-negative breast_cancer .
20937842	0	Matriptase-2	0,12	hemojuvelin	57,68	Matriptase-2	hemojuvelin	164656	148738	Gene	Gene	forms|amod|START_ENTITY forms|nmod|END_ENTITY	Matriptase-2 - and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression .
26219353	0	Matrix-metalloproteinase-9	0,26	Cathepsin_K	55,66	Matrix-metalloproteinase-9	Cathepsin K	4318	1513	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin_K .
26219353	0	Matrix-metalloproteinase-9	0,26	Cathepsin_K	55,66	Matrix-metalloproteinase-9	Cathepsin K	4318	1513	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin_K .
15456771	0	Matrix_GLA_protein	0,18	VEGF	30,34	Matrix GLA protein	VEGF	4256	7422	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Matrix_GLA_protein stimulates VEGF expression through increased transforming_growth_factor-beta1 activity in endothelial cells .
11741887	0	Matrix_GLA_protein	0,18	bone_morphogenetic_protein-2	45,73	Matrix GLA protein	bone morphogenetic protein-2	4256	650	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Matrix_GLA_protein , a regulatory protein for bone_morphogenetic_protein-2 .
27009385	0	Matrix_Gla_protein	0,18	miR-155	33,40	Matrix Gla protein	miR-155	4256	406947	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	Matrix_Gla_protein repression by miR-155 promotes oncogenic signals in breast_cancer MCF-7 cells .
25339983	0	Matrix_Metallopeptidase-1	20,45	Fra-1	0,5	Matrix Metallopeptidase-1	Fra-1	4312	8061	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Fra-1 regulation of Matrix_Metallopeptidase-1 -LRB- MMP-1 -RRB- in metastatic variants of MDA-MB-231 breast_cancer cells .
25339983	0	Matrix_Metallopeptidase-1	20,45	MMP-1	47,52	Matrix Metallopeptidase-1	MMP-1	4312	4312	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Fra-1 regulation of Matrix_Metallopeptidase-1 -LRB- MMP-1 -RRB- in metastatic variants of MDA-MB-231 breast_cancer cells .
25992485	0	Matrix_Metalloproteinase-1	97,123	Cyclooxygenase-2	12,28	Matrix Metalloproteinase-1	Cyclooxygenase-2	4312	5743	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of Cyclooxygenase-2 , Interleukin-1b and Fibroblast_Growth_Factor-2 in the Activation of Matrix_Metalloproteinase-1 in Sheared-Chondrocytes and Articular Cartilage .
27001612	0	Matrix_Metalloproteinase-2	130,156	High_Mobility_Group_A1	4,26	Matrix Metalloproteinase-2	High Mobility Group A1	4313	3159	Gene	Gene	START_ENTITY|nsubj|gene gene|compound|END_ENTITY	The High_Mobility_Group_A1 -LRB- HMGA1 -RRB- gene is highly overexpressed in human uterine serous_carcinomas and carcinosarcomas and drives Matrix_Metalloproteinase-2 -LRB- MMP-2 -RRB- in a subset of tumors .
20628524	0	Matrix_Metalloproteinase-7	26,52	E-Cadherin	12,22	Matrix Metalloproteinase-7	E-Cadherin	4316	999	Gene	Gene	Proliferation|compound|START_ENTITY Cleavage|nmod|Proliferation Cleavage|nmod|END_ENTITY	Cleavage of E-Cadherin by Matrix_Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA .
20628524	0	Matrix_Metalloproteinase-7	26,52	RhoA	132,136	Matrix Metalloproteinase-7	RhoA	4316	387	Gene	Gene	Proliferation|compound|START_ENTITY Cleavage|nmod|Proliferation Cleavage|nmod|END_ENTITY	Cleavage of E-Cadherin by Matrix_Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA .
25520561	0	Matrix_Metalloproteinase-9	23,49	Cavin-3	15,22	Matrix Metalloproteinase-9	Cavin-3	4318	112464	Gene	Gene	Axis|compound|START_ENTITY Role|dep|Axis Role|nmod|END_ENTITY	A Role for the Cavin-3 / Matrix_Metalloproteinase-9 Signaling Axis in the Regulation of PMA-Activated Human HT1080 Fibrosarcoma Cell Neoplastic Phenotype .
26713823	0	Matrix_Metalloproteinase-9	12,38	MMP-9	40,45	Matrix Metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Matrix_Metalloproteinase-9 -LRB- MMP-9 -RRB- as a Prognostic Factor in Epithelial and Lymphatic Neoplasia .
26564502	0	Matrix_Metalloproteinase_1	65,91	Growth_Differentiation_Factor_15	0,32	Matrix Metalloproteinase 1	Growth Differentiation Factor 15	4312	9518	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Growth_Differentiation_Factor_15 Inhibits Elevated Expression of Matrix_Metalloproteinase_1 Induced by Pooled Serum in Patients with Coroanry_Artery_Ectasia .
24461475	0	Matrix_metallopeptidase_2	0,25	MHC_class_I_polypeptide-related_sequence_A	42,84	Matrix metallopeptidase 2	MHC class I polypeptide-related sequence A	4313	100507436	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Matrix_metallopeptidase_2 -LRB- MMP2 -RRB- mediates MHC_class_I_polypeptide-related_sequence_A -LRB- MICA -RRB- shedding in renal_cell_carcinoma .
19302792	0	Matrix_metalloproteinase-1	0,26	IL-1beta	49,57	Matrix metalloproteinase-1	IL-1beta	4312	3553	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Matrix_metalloproteinase-1 expression induced by IL-1beta requires acid_sphingomyelinase .
14550952	0	Matrix_metalloproteinase-1	23,49	MMP-1	51,56	Matrix metalloproteinase-1	MMP-1	4312	4312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A relationship between Matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- promoter polymorphism and cervical cancer progression .
9683296	0	Matrix_metalloproteinase-1	0,26	epidermal_growth_factor	41,64	Matrix metalloproteinase-1	epidermal growth factor	4312	1950	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Matrix_metalloproteinase-1 is induced by epidermal_growth_factor in human bladder_tumour cell lines and is detectable in urine of patients with bladder_tumours .
15972796	0	Matrix_metalloproteinase-1	0,26	hepatocyte_growth_factor	44,68	Matrix metalloproteinase-1	hepatocyte growth factor	4312	3082	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Matrix_metalloproteinase-1 up-regulation by hepatocyte_growth_factor in human dermal fibroblasts via ERK signaling pathway involves Ets1 and Fli1 .
16598647	0	Matrix_metalloproteinase-1	0,26	plasmin	42,49	Matrix metalloproteinase-1	plasmin	4312	5340	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Matrix_metalloproteinase-1 activation via plasmin generated on alveolar epithelial cell surfaces .
22427646	0	Matrix_metalloproteinase-10	0,27	TIMP-1	94,100	Matrix metalloproteinase-10	TIMP-1	4319	7076	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Matrix_metalloproteinase-10 -LRB- MMP-10 -RRB- interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 : binding studies and crystal structure .
19762781	0	Matrix_metalloproteinase-10	0,27	thrombin	46,54	Matrix metalloproteinase-10	thrombin	4319	2147	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Matrix_metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation .
24563279	0	Matrix_metalloproteinase-13	0,27	Matrix_metalloproteinase-13	95,122	Matrix metalloproteinase-13	Matrix metalloproteinase-13	4322	4322	Gene	Gene	expression|amod|START_ENTITY expression|dep|expression expression|compound|END_ENTITY	Matrix_metalloproteinase-13 expression in the progression of colorectal_adenoma_to_carcinoma : Matrix_metalloproteinase-13 expression in the colorectal_adenoma_and_carcinoma .
24563279	0	Matrix_metalloproteinase-13	95,122	Matrix_metalloproteinase-13	0,27	Matrix metalloproteinase-13	Matrix metalloproteinase-13	4322	4322	Gene	Gene	expression|compound|START_ENTITY expression|dep|expression expression|amod|END_ENTITY	Matrix_metalloproteinase-13 expression in the progression of colorectal_adenoma_to_carcinoma : Matrix_metalloproteinase-13 expression in the colorectal_adenoma_and_carcinoma .
26025700	0	Matrix_metalloproteinase-2	0,26	MMP-2	28,33	Matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- gene polymorphism and cardiovascular comorbidity in type 2 diabetes patients .
15307819	0	Matrix_metalloproteinase-2	0,26	adrenomedullin	39,53	Matrix metalloproteinase-2	adrenomedullin	81686(Tax:10116)	25026(Tax:10116)	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Matrix_metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator .
15570615	0	Matrix_metalloproteinase-2	0,26	tumor_necrosis_factor_alpha	64,91	Matrix metalloproteinase-2	tumor necrosis factor alpha	282872(Tax:9913)	280943(Tax:9913)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- expression and regulation by tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- in the bovine corpus luteum .
16857167	0	Matrix_metalloproteinase-2	0,26	tumor_necrosis_factor_alpha	42,69	Matrix metalloproteinase-2	tumor necrosis factor alpha	81686(Tax:10116)	24835(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Matrix_metalloproteinase-2 contributes to tumor_necrosis_factor_alpha induced apoptosis in cultured rat cardiac myocytes .
23608488	0	Matrix_metalloproteinase-3	32,58	MMP-3	60,65	Matrix metalloproteinase-3	MMP-3	4314	4314	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	IL-4 inhibition of IL-1 induced Matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun_N-terminal_kinase -LRB- JNK -RRB- .
18641052	0	Matrix_metalloproteinase-3	0,26	VEGF	65,69	Matrix metalloproteinase-3	VEGF	17392(Tax:10090)	22339(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Matrix_metalloproteinase-3 enhances the free fatty_acids-induced VEGF expression in adipocytes through toll-like_receptor_2 .
10770843	0	Matrix_metalloproteinase-3	0,26	agrin	35,40	Matrix metalloproteinase-3	agrin	4314	375790	Gene	Gene	removes|nsubj|START_ENTITY removes|dobj|END_ENTITY	Matrix_metalloproteinase-3 removes agrin from synaptic basal lamina .
20113256	0	Matrix_metalloproteinase-7	0,26	MMP-7	28,33	Matrix metalloproteinase-7	MMP-7	4316	4316	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Matrix_metalloproteinase-7 -LRB- MMP-7 -RRB- polymorphism is a risk factor for endometrial_cancer susceptibility .
20586780	0	Matrix_metalloproteinase-7	0,26	heparin-binding_epidermal_growth_factor-like_growth_factor	37,95	Matrix metalloproteinase-7	heparin-binding epidermal growth factor-like growth factor	4316	1839	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Matrix_metalloproteinase-7 activates heparin-binding_epidermal_growth_factor-like_growth_factor in cutaneous_squamous_cell_carcinoma .
15736480	0	Matrix_metalloproteinase-9	0,26	MMP-9	28,33	Matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- immunoreactive protein has modest prognostic value in locally advanced breast_carcinoma patients treated with an adjuvant antiestrogen therapy .
20298757	0	Matrix_metalloproteinase-9	0,26	MMP-9	28,33	Matrix metalloproteinase-9	MMP-9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression and extracellular_signal-regulated_kinase_1_and_2 -LRB- ERK1/2 -RRB- activation in exercise-reduced neuronal apoptosis after stroke .
17484881	0	Matrix_metalloproteinase-9	0,26	MUC-2	37,42	Matrix metalloproteinase-9	MUC-2	17395(Tax:10090)	17831(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Matrix_metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation .
14657171	0	Matrix_metalloproteinase-9	0,26	NG2	90,93	Matrix metalloproteinase-9	NG2	17395(Tax:10090)	121021(Tax:10090)	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|advcl|processing processing|dobj|proteoglycan proteoglycan|compound|END_ENTITY	Matrix_metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan .
21756907	0	Matrix_metalloproteinase-9	0,26	NG2	53,56	Matrix metalloproteinase-9	NG2	4318	1464	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Matrix_metalloproteinase-9 controls proliferation of NG2 + progenitor cells immediately after spinal_cord_injury .
21219539	0	Matrix_metalloproteinase-9	0,26	Snail	64,69	Matrix metalloproteinase-9	Snail	4318	6615	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Matrix_metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial-mesenchymal transition .
17362932	0	Matrix_metalloproteinase-9	0,26	TNF-alpha	37,46	Matrix metalloproteinase-9	TNF-alpha	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Matrix_metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal , glial cells and its absence extends life in a transgenic mouse model of amyotrophic_lateral_sclerosis .
24885469	0	Matrix_metalloproteinase_12	0,27	heterogeneous_nuclear_ribonucleoprotein_K	42,83	Matrix metalloproteinase 12	heterogeneous nuclear ribonucleoprotein K	4321	3190	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Matrix_metalloproteinase_12 is induced by heterogeneous_nuclear_ribonucleoprotein_K and promotes migration and invasion in nasopharyngeal_carcinoma .
23185634	0	Matrix_metalloproteinase_13	0,27	osterix	99,106	Matrix metalloproteinase 13	osterix	17386(Tax:10090)	170574(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Matrix_metalloproteinase_13 -LRB- MMP13 -RRB- is a direct target of osteoblast-specific transcription factor osterix -LRB- Osx -RRB- in osteoblasts .
10896208	0	Matrix_metalloproteinase_2	0,26	MMP-2	28,33	Matrix metalloproteinase 2	MMP-2	4313	4313	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- immunoreactive protein is associated with poor grade and survival in brain_neoplasms .
20039633	0	Matrix_metalloproteinase_2	0,26	MMP2	28,32	Matrix metalloproteinase 2	MMP2	4313	4313	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Matrix_metalloproteinase_2 -LRB- MMP2 -RRB- inhibition : DFT and QM/MM studies of the deprotonation-initialized ring-opening reaction of the sulfoxide analogue of SB-3CT .
16690877	0	Matrix_metalloproteinase_2	0,26	TGF-beta1	75,84	Matrix metalloproteinase 2	TGF-beta1	81686(Tax:10116)	59086(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Matrix_metalloproteinase_2 activation of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- and TGF-beta1-type_II_receptor signaling within the aged arterial wall .
23632023	0	Matrix_metalloproteinase_8	0,26	interleukins_6_and_8	69,89	Matrix metalloproteinase 8	interleukins 6 and 8	4317	3569;3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Matrix_metalloproteinase_8 -LRB- collagenase_2 -RRB- induces the expression of interleukins_6_and_8 in breast_cancer cells .
12149643	0	Matrix_metalloproteinase_9	0,26	ICAM-1	72,78	Matrix metalloproteinase 9	ICAM-1	4318	3383	Gene	Gene	cleaves|amod|START_ENTITY END_ENTITY|nsubj|cleaves	Matrix_metalloproteinase_9 -LRB- MMP-9 / gelatinase B -RRB- proteolytically cleaves ICAM-1 and participates in tumor cell resistance to natural killer cell-mediated cytotoxicity .
15316122	0	Matrix_metalloproteinase_9	0,26	MMP-9	28,33	Matrix metalloproteinase 9	MMP-9	4318	4318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- gene polymorphism and MMP-9 plasma levels in primary_Sjogren 's _ syndrome .
18276934	0	Matrix_metalloproteinase_9	0,26	MMP9	28,32	Matrix metalloproteinase 9	MMP9	4318	4318	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Matrix_metalloproteinase_9 -LRB- MMP9 -RRB- expression in preeclamptic decidua and MMP9 induction by tumor_necrosis_factor_alpha and interleukin_1_beta in human first trimester decidual cells .
11439337	0	Max	53,56	Myc	0,3	Max	Myc	60661(Tax:10116)	24577(Tax:10116)	Gene	Gene	absence|nmod|START_ENTITY cells|nmod|absence apoptosis|nmod|cells apoptosis|nsubj|drives drives|compound|END_ENTITY	Myc drives apoptosis in PC12 cells in the absence of Max .
12695332	0	Max	39,42	Myc	34,37	Max	Myc	40095(Tax:7227)	31310(Tax:7227)	Gene	Gene	network|appos|START_ENTITY network|compound|END_ENTITY	Genomic binding by the Drosophila Myc , Max , Mad/Mnt transcription factor network .
12747840	0	Max	70,73	Myc	12,15	Max	Myc	4149	4609	Gene	Gene	essential|nsubj|START_ENTITY shows|ccomp|essential shows|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression .
1459463	0	Max	19,22	Myc	26,29	Max	Myc	4149	4609	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	Biphasic effect of Max on Myc cotransformation activity and dependence on amino - and carboxy-terminal Max functions .
1644290	0	Max	118,121	Myc	0,3	Max	Myc	4149	4609	Gene	Gene	cross-interference|nmod|START_ENTITY cells|amod|cross-interference transform|dobj|cells function|xcomp|transform function|nsubj|oncoproteins oncoproteins|compound|END_ENTITY	Myc family oncoproteins function through a common pathway to transform normal cells in culture : cross-interference by Max and trans-acting dominant mutants .
19498040	0	Max	19,22	Myc	80,83	Max	Myc	4149	4609	Gene	Gene	homodimer|compound|START_ENTITY Stabilizers|nmod|homodimer inhibit|nsubj|Stabilizers inhibit|ccomp|function function|nsubj|END_ENTITY	Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function .
19887915	0	Max	26,29	Myc	0,3	Max	Myc	4149	4609	Gene	Gene	life|nmod|START_ENTITY life|nsubj|END_ENTITY	Myc 's secret life without Max .
2006410	0	Max	0,3	Myc	95,98	Max	Myc	4149	4609	Gene	Gene	START_ENTITY|dep|protein protein|acl:relcl|forms forms|nmod|END_ENTITY	Max : a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc .
20426839	0	Max	19,22	Myc	0,3	Max	Myc	4149	4609	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Myc interacts with Max and Miz1 to repress C/EBPdelta promoter activity and gene expression .
7630640	0	Max	96,99	Myc	74,77	Max	Myc	60661(Tax:10116)	24577(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Determination Determination|nmod|sequences sequences|amod|responsible responsible|nmod|regulation regulation|nmod|END_ENTITY	Determination of sequences responsible for the differential regulation of Myc function by delta Max and Max .
8417337	0	Max	70,73	Myc	48,51	Max	Myc	4149	4609	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Sequence-specific transcriptional activation by Myc and repression by Max .
8425218	0	Max	33,36	Myc	54,57	Max	Myc	4149	4609	Gene	Gene	partner|nmod|START_ENTITY partner|acl:relcl|antagonizes antagonizes|dobj|activity activity|compound|END_ENTITY	Mad : a heterodimeric partner for Max that antagonizes Myc transcriptional activity .
7700652	0	Max	22,25	c-myc	41,46	Max	c-myc	4149	4609	Gene	Gene	binding|compound|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	Analysis of c-Myc and Max binding to the c-myc promoter : evidence that autosuppression occurs via an indirect mechanism .
10229200	0	Max	68,71	dMax	45,49	Max	dMax	17187(Tax:10090)	40095(Tax:7227)	Gene	Gene	variant|nmod|START_ENTITY variant|compound|END_ENTITY	Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc .
21670079	0	Max	37,40	miR-193a	14,22	Max	miR-193a	4149	406968	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of miR-193a expression by Max and RXRa activates K-Ras and PLAU to mediate distinct aspects of cellular transformation .
20214878	0	Max	44,47	miR-22	27,33	Max	miR-22	4149	407004	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	Differentiation-associated miR-22 represses Max expression and inhibits cell cycle progression .
22964333	0	Max_binding_protein	18,37	Nck1	68,72	Max binding protein	Nck1	4335	4690	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Max_binding_protein as a novel binding protein of Nck1 and characterization of its role in inhibiting human liver_cancer SK-HEP-1 cells .
15735724	0	Mayven	0,6	c-Jun	15,20	Mayven	c-Jun	11275	3725	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Mayven induces c-Jun expression and cyclin_D1 activation in breast_cancer cells .
20650879	0	Mc2r	30,34	FOXL2	47,52	Mc2r	FOXL2	17200(Tax:10090)	26927(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Synergistic activation of the Mc2r promoter by FOXL2 and NR5A1 in mice .
10574991	0	Mcd4p	38,43	Pig-n	0,5	Mcd4p	Pig-n	853690(Tax:4932)	23556	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Pig-n , a mammalian homologue of yeast Mcd4p , is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol .
2265564	0	Mcf-2	26,31	Dbl	33,36	Mcf-2	Dbl	109904(Tax:10090)	109904(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the mouse Mcf-2 -LRB- Dbl -RRB- protooncogene within a conserved linkage group on the mouse X chromosome .
9209064	0	Mck1	0,4	pyruvate_kinase	103,118	Mck1	pyruvate kinase	855409(Tax:4932)	851193(Tax:4932)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Mck1 , a member of the glycogen synthase kinase 3 family of protein kinases , is a negative regulator of pyruvate_kinase in the yeast Saccharomyces_cerevisiae .
22268450	0	Mcl-1	164,169	Akt	128,131	Mcl-1	Akt	4170	207	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Epstein-Barr_virus latent membrane protein-1 protects B-cell_lymphoma from rituximab-induced apoptosis through miR-155-mediated Akt activation and up-regulation of Mcl-1 .
24118207	0	Mcl-1	36,41	BRAF	10,14	Mcl-1	BRAF	4170	673	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Oncogenic BRAF signalling increases Mcl-1 expression in cutaneous metastatic_melanoma .
25873592	0	Mcl-1	132,137	BRAF	83,87	Mcl-1	BRAF	4170	673	Gene	Gene	Suppression|nmod|START_ENTITY Resistance|nmod|Suppression Resistance|nsubj|Inhibitor Inhibitor|compound|END_ENTITY	The Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK Expression .
14695629	0	Mcl-1	0,5	Bax	16,19	Mcl-1	Bax	4170	581	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	Mcl-1 and Bcl-2 / Bax ratio are associated with treatment response but not with Rai stage in B-cell_chronic_lymphocytic_leukemia .
18025305	0	Mcl-1	0,5	Bax	21,24	Mcl-1	Bax	4170	581	Gene	Gene	determines|nsubj|START_ENTITY determines|dobj|dependency dependency|compound|END_ENTITY	Mcl-1 determines the Bax dependency of Nbk/Bik-induced apoptosis .
22201517	0	Mcl-1	36,41	Bax	42,45	Mcl-1	Bax	60430(Tax:10116)	24887(Tax:10116)	Gene	Gene	ratio|nmod|START_ENTITY changes|nmod|ratio changes|dep|expression expression|compound|END_ENTITY	Age-related changes in the ratio of Mcl-1 / Bax expression in the rat cochlea .
24680709	0	Mcl-1	20,25	Bax	63,66	Mcl-1	Bax	4170	581	Gene	Gene	degradation|compound|START_ENTITY induces|dobj|degradation induces|advcl|trigger trigger|dobj|translocation translocation|compound|END_ENTITY	Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma .
24865469	0	Mcl-1	144,149	Bax	48,51	Mcl-1	Bax	4170	581	Gene	Gene	protein|compound|START_ENTITY bound|nmod|protein bound|nsubj|study study|nmod|peptides peptides|nmod|Bim Bim|compound|END_ENTITY	Molecular dynamics study of segment peptides of Bax , Bim , and Mcl-1 BH3 domain of the apoptosis-regulating proteins bound to the anti-apoptotic Mcl-1 protein .
19088028	0	Mcl-1	70,75	Bcl-2	98,103	Mcl-1	Bcl-2	4170	596	Gene	Gene	expressing|xcomp|START_ENTITY expressing|nmod|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
9002967	0	Mcl-1	0,5	Bcl-2	9,14	Mcl-1	Bcl-2	17210(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Mcl-1 , a Bcl-2 family member , delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions .
16380381	0	Mcl-1	0,5	Bid	31,34	Mcl-1	Bid	4170	637	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome_c release and its role in receptor-mediated apoptosis .
26779944	0	Mcl-1	80,85	Bid	86,89	Mcl-1	Bid	4170	637	Gene	Gene	inhibitor|nmod|START_ENTITY kingiana|nmod|inhibitor polyketides|nmod|kingiana Kingianins_O-Q|dep|polyketides Kingianins_O-Q|parataxis|interaction interaction|nsubj|END_ENTITY	Kingianins_O-Q : Pentacyclic polyketides from Endiandra kingiana as inhibitor of Mcl-1 / Bid interaction .
21977009	0	Mcl-1	112,117	Bim	106,109	Mcl-1	Bim	4170	10018	Gene	Gene	imbalance|compound|START_ENTITY imbalance|compound|END_ENTITY	Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance .
22270368	0	Mcl-1	89,94	Bim	39,42	Mcl-1	Bim	4170	10018	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Up-regulation of pro-apoptotic protein Bim and down-regulation of anti-apoptotic protein Mcl-1 cooperatively mediate enhanced tumor cell death induced by the combination of ERK kinase -LRB- MEK -RRB- inhibitor and microtubule inhibitor .
25437618	0	Mcl-1	89,94	Bim	120,123	Mcl-1	Bim	4170	10018	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Design , synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1 / Bcl-xL inhibitors .
23553788	0	Mcl-1	28,33	CK2	15,18	Mcl-1	CK2	60430(Tax:10116)	81650(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Protein kinase CK2 enhances Mcl-1 gene expression through the serum_response_factor-mediated pathway in the rat hippocampus .
18292181	0	Mcl-1	63,68	CUGBP2	111,117	Mcl-1	CUGBP2	4170	10659	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Translation inhibition during cell cycle arrest and apoptosis : Mcl-1 is a novel target for RNA binding protein CUGBP2 .
21822052	0	Mcl-1	0,5	DR5	42,45	Mcl-1	DR5	4170	8795	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax -LRB- GX15-070 -RRB- contribute in the sensitization of B-NHL cells to TRAIL apoptosis .
22751450	0	Mcl-1	18,23	GSK-3b	32,38	Mcl-1	GSK-3b	4170	2932	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Downregulation of Mcl-1 through GSK-3b activation contributes to arsenic_trioxide-induced apoptosis in acute_myeloid_leukemia cells .
14999683	0	Mcl-1	33,38	Hepatocyte_growth_factor	0,24	Mcl-1	Hepatocyte growth factor	4170	3082	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces Mcl-1 in primary human hepatocytes and inhibits CD95-mediated apoptosis via Akt .
15351513	0	Mcl-1	14,19	IGF-I	66,71	Mcl-1	IGF-I	17210(Tax:10090)	16000(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of Mcl-1 in cerebellar granule neurons is regulated by IGF-I in a developmentally specific fashion .
10583232	0	Mcl-1	0,5	IL-6	37,41	Mcl-1	IL-6	4170	3569	Gene	Gene	co-regulated|nsubjpass|START_ENTITY co-regulated|nmod|END_ENTITY	Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells .
12479056	0	Mcl-1	116,121	IL-6	0,4	Mcl-1	IL-6	4170	3569	Gene	Gene	pathway|nmod|START_ENTITY activation|nmod|pathway inhibits|nmod|activation inhibits|nsubj|END_ENTITY	IL-6 inhibits apoptosis of human myeloma cell line XG-7 through activation of JAK/STAT pathway and up-regulation of Mcl-1 .
17072336	0	Mcl-1	111,116	IL-6	28,32	Mcl-1	IL-6	4170	3569	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|loop loop|compound|END_ENTITY	The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate_cancer is mediated by Mcl-1 .
18497081	0	Mcl-1	0,5	IL-6	22,26	Mcl-1	IL-6	4170	3569	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late_stage_prostate_carcinoma .
21880146	0	Mcl-1	123,128	IL-6	118,122	Mcl-1	IL-6	4170	3569	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Mesothelin confers pancreatic_cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-kB activation and IL-6 / Mcl-1 overexpression .
25781882	0	Mcl-1	17,22	JAK2	94,98	Mcl-1	JAK2	4170	3717	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	JAK2V617F Drives Mcl-1 Expression and Sensitizes Hematologic Cell Lines to Dual Inhibition of JAK2 and Bcl-xL .
24769731	0	Mcl-1	36,41	Ku70	8,12	Mcl-1	Ku70	4170	2547	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis .
21907705	0	Mcl-1	29,34	Mcl-1	80,85	Mcl-1	Mcl-1	4170	4170	Gene	Gene	ubiquitination|compound|START_ENTITY controls|dobj|ubiquitination controls|nmod|regulation regulation|nmod|interaction interaction|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
21907705	0	Mcl-1	80,85	Mcl-1	29,34	Mcl-1	Mcl-1	4170	4170	Gene	Gene	interaction|compound|START_ENTITY regulation|nmod|interaction controls|nmod|regulation controls|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
23904379	0	Mcl-1	17,22	MiR-106a	0,8	Mcl-1	MiR-106a	4170	406899	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MiR-106a targets Mcl-1 to suppress cisplatin resistance of ovarian_cancer A2780 cells .
23551751	0	Mcl-1	17,22	MiR-139	0,7	Mcl-1	MiR-139	4170	406931	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma .
26878343	0	Mcl-1	63,68	Myeloid_Cell_Leukemia_1	38,61	Mcl-1	Myeloid Cell Leukemia 1	4170	4170	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of 2-Indole-acylsulfonamide Myeloid_Cell_Leukemia_1 -LRB- Mcl-1 -RRB- Inhibitors Using Fragment-Based Methods .
23804716	0	Mcl-1	14,19	NKG2D	0,5	Mcl-1	NKG2D	4170	22914	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase .
22525702	0	Mcl-1	0,5	NOXA	83,87	Mcl-1	NOXA	4170	5366	Gene	Gene	Phosphorylation|compound|START_ENTITY defines|nsubj|Phosphorylation defines|dobj|resistance resistance|acl:relcl|overcome overcome|nmod|expression expression|compound|END_ENTITY	Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells .
17703234	0	Mcl-1	71,76	Noxa	77,81	Mcl-1	Noxa	4170	5366	Gene	Gene	acts|nmod|START_ENTITY Crosstalk|dep|acts Crosstalk|dep|axis axis|compound|END_ENTITY	Crosstalk among Bcl-2 family members in B-CLL : seliciclib acts via the Mcl-1 / Noxa axis and gradual exhaustion of Bcl-2 protection .
19088028	0	Mcl-1	70,75	Noxa	13,17	Mcl-1	Noxa	4170	5366	Gene	Gene	expressing|xcomp|START_ENTITY cells|acl|expressing sensitizes|dobj|cells sensitizes|nsubj|Induction Induction|nmod|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
19936928	0	Mcl-1	113,118	Noxa	119,123	Mcl-1	Noxa	4170	5366	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1 / Noxa balance .
19946262	0	Mcl-1	141,146	Noxa	147,151	Mcl-1	Noxa	4170	5366	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1 / Noxa axis .
19946262	0	Mcl-1	44,49	Noxa	147,151	Mcl-1	Noxa	4170	5366	Gene	Gene	neutralizes|dobj|START_ENTITY neutralizes|advcl|activating activating|nmod|axis axis|compound|END_ENTITY	Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1 / Noxa axis .
21907705	0	Mcl-1	29,34	Noxa	0,4	Mcl-1	Noxa	4170	5366	Gene	Gene	ubiquitination|compound|START_ENTITY controls|dobj|ubiquitination controls|nsubj|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
21907705	0	Mcl-1	80,85	Noxa	0,4	Mcl-1	Noxa	4170	5366	Gene	Gene	interaction|compound|START_ENTITY regulation|nmod|interaction controls|nmod|regulation controls|nsubj|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
23733106	0	Mcl-1	61,66	Noxa	6,10	Mcl-1	Noxa	17210(Tax:10090)	58801(Tax:10090)	Gene	Gene	uses|nmod|START_ENTITY uses|nsubj|END_ENTITY	Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1 .
12475993	0	Mcl-1	27,32	Tankyrase_1	0,11	Mcl-1	Tankyrase 1	4170	8658	Gene	Gene	proteins|compound|START_ENTITY interacts|nmod|proteins interacts|nsubj|END_ENTITY	Tankyrase_1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis .
21907705	0	Mcl-1	29,34	USP9X	86,91	Mcl-1	USP9X	4170	8239	Gene	Gene	ubiquitination|compound|START_ENTITY controls|dobj|ubiquitination controls|nmod|regulation regulation|nmod|interaction interaction|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
21907705	0	Mcl-1	80,85	USP9X	86,91	Mcl-1	USP9X	4170	8239	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
23171055	0	Mcl-1	22,27	USP9X	32,37	Mcl-1	USP9X	4170	8239	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition .
23097624	0	Mcl-1	70,75	USP9x	15,20	Mcl-1	USP9x	4170	8239	Gene	Gene	stabilization|nmod|START_ENTITY confers|nmod|stabilization confers|nsubj|END_ENTITY	Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1 .
24991768	0	Mcl-1	25,30	Usp9x	0,5	Mcl-1	Usp9x	4170	8239	Gene	Gene	downregulation|compound|START_ENTITY downregulation|amod|END_ENTITY	Usp9x - and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung_cancer cells .
21423203	0	Mcl-1	31,36	XBP-1	51,56	Mcl-1	XBP-1	4170	7494	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress .
24261825	0	Mcl-1	80,85	b-TrCP	25,31	Mcl-1	b-TrCP	4170	8945	Gene	Gene	degradation|compound|START_ENTITY mediates|dobj|degradation mediates|nsubj|END_ENTITY	The E3 ubiquitin ligases b-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1 , resulting in apoptosis .
21220745	0	Mcl-1	16,21	c-Abl	0,5	Mcl-1	c-Abl	4170	25	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	c-Abl regulates Mcl-1 gene expression in chronic_lymphocytic_leukemia cells .
11314001	0	Mcl-1	57,62	interleukin-6	112,125	Mcl-1	interleukin-6	4170	3569	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	The involvement of PI_3-K / Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6 .
26078955	0	Mcl-1	0,5	miR-26b	27,34	Mcl-1	miR-26b	4170	407017	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	Mcl-1 Is a Novel Target of miR-26b That Is Associated with the Apoptosis Induced by TRAIL in HCC Cells .
25674218	0	Mcl-1	90,95	miR-29a	0,7	Mcl-1	miR-29a	4170	407021	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	miR-29a promotes intestinal epithelial apoptosis in ulcerative_colitis by down-regulating Mcl-1 .
24992675	0	Mcl-1	17,22	miR-29b	49,56	Mcl-1	miR-29b	4170	407024	Gene	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian_cancer .
19582795	0	Mcl-1	52,57	myeloid_cell_leukemia-1_protein	19,50	Mcl-1	myeloid cell leukemia-1 protein	4170	4170	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic role of myeloid_cell_leukemia-1_protein -LRB- Mcl-1 -RRB- expression in human gastric_cancer .
23244564	0	Mcl-1	45,50	myeloid_cell_leukemia_1	20,43	Mcl-1	myeloid cell leukemia 1	4170	4170	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of potent myeloid_cell_leukemia_1 -LRB- Mcl-1 -RRB- inhibitors using fragment-based methods and structure-based design .
21841196	0	Mcl-1	112,117	myeloid_cell_leukemia_sequence_1	78,110	Mcl-1	myeloid cell leukemia sequence 1	4170	4170	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Activating_transcription_factor-6 -LRB- ATF6 -RRB- mediates apoptosis with reduction of myeloid_cell_leukemia_sequence_1 -LRB- Mcl-1 -RRB- protein via induction of WW_domain_binding_protein_1 .
25091479	0	Mcl-1	32,37	p32	0,3	Mcl-1	p32	4170	708	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	p32 , a novel binding partner of Mcl-1 , positively regulates mitochondrial Ca -LRB- 2 + -RRB- uptake and apoptosis .
23825534	0	Mcl-1L	15,21	IL-6	0,4	Mcl-1L	IL-6	4170	24498(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt / CREB signaling pathway in hepatocytes : implication of an anti-apoptotic role during liver_regeneration .
23824576	0	Mcl1	0,4	p27Kip1	93,100	Mcl1	p27Kip1	4170	1027	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Mcl1 regulates the terminal mitosis of neural_precursor_cells in the mammalian brain through p27Kip1 .
23675312	0	Mcm1	39,43	Bck2	0,4	Mcm1	Bck2	855060(Tax:4932)	856914(Tax:4932)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast .
19596791	0	Mcm1	124,128	PHO5	116,120	Mcm1	PHO5	855060(Tax:4932)	852390(Tax:4932)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Coupling phosphate homeostasis to cell cycle-specific transcription : mitotic activation of Saccharomyces_cerevisiae PHO5 by Mcm1 and Forkhead proteins .
2689875	0	Mcm1	79,83	alpha_2	16,23	Mcm1	alpha 2	855060(Tax:4932)	850406(Tax:4932)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Yeast repressor alpha_2 binds to its operator cooperatively with yeast protein Mcm1 .
25602958	0	Mcm10	42,47	RecQL4	0,6	Mcm10	RecQL4	55388	9401	Gene	Gene	association|nmod|START_ENTITY required|nmod|association required|nsubjpass|END_ENTITY	RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells .
20381454	0	Mcm10p	18,24	Ctf4p	0,5	Mcm10p	Ctf4p	854656(Tax:4932)	856254(Tax:4932)	Gene	Gene	facilitates|dobj|START_ENTITY facilitates|nsubj|END_ENTITY	Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast .
15448142	0	Mcm2	0,4	ATM	30,33	Mcm2	ATM	380451(Tax:8355)	398148(Tax:8355)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses .
11782448	0	Mcm22p	54,60	Ctf3p	0,5	Mcm22p	Ctf3p	853599(Tax:4932)	851097(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ctf3p , the Mis6 budding yeast homolog , interacts with Mcm22p and Mcm16p at the yeast outer kinetochore .
20623209	0	Mcm6	79,83	Cdt1	50,54	Mcm6	Cdt1	4175	81620	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	1H , _ 15N_and_13C chemical shift assignments of the Cdt1 binding domain of human Mcm6 .
24023717	0	Mcs	149,152	fry	130,133	Mcs	fry	24899(Tax:10116)	304244(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Mapping of Mcs30 , a new mammary_carcinoma susceptibility quantitative trait locus -LRB- QTL30 -RRB- on rat chromosome 12 : identification of fry as a candidate Mcs gene .
11252168	0	Mcs1	77,81	mammary_cancer_susceptibility_1	44,75	Mcs1	mammary cancer susceptibility 1	326383(Tax:10116)	326383(Tax:10116)	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Analysis of candidate genes included in the mammary_cancer_susceptibility_1 -LRB- Mcs1 -RRB- region .
12811827	0	Mda-7	0,5	IL-24	6,11	Mda-7	IL-24	11009	11009	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Mda-7 / IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways .
22938480	0	Mda-9	0,5	syntenin	6,14	Mda-9	syntenin	6386	6386	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Mda-9 / syntenin promotes human brain_glioma migration through focal adhesion kinase -LRB- FAK -RRB- - JNK and FAK-AKT signaling .
25851349	0	Mdig	0,4	p27	78,81	Mdig	p27	84864	10671	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Mdig , a lung_cancer-associated gene , regulates cell cycle progression through p27 -LRB- KIP1 -RRB- .
10096022	0	Mdk	32,35	midkine	18,25	Mdk	midkine	4192	17242(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disruption of the midkine gene -LRB- Mdk -RRB- resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour .
9371494	0	Mdm-2	0,5	DNA-dependent_protein_kinase	25,53	Mdm-2	DNA-dependent protein kinase	4193	5591	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Mdm-2 phosphorylation by DNA-dependent_protein_kinase prevents interaction with p53 .
12370832	0	Mdm-2	0,5	p53	93,96	Mdm-2	p53	4193	7157	Gene	Gene	binding|compound|START_ENTITY regulated|nsubjpass|binding regulated|nmod|disruption disruption|nmod|Thr18 Thr18|compound|END_ENTITY	Mdm-2 binding and TAF -LRB- II -RRB- 31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21 .
8720983	0	Mdm-2	0,5	p53	24,27	Mdm-2	p53	4193	7157	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Mdm-2 is not induced by p53 in human keratinocytes in vivo .
9371494	0	Mdm-2	0,5	p53	80,83	Mdm-2	p53	4193	7157	Gene	Gene	phosphorylation|amod|START_ENTITY prevents|nsubj|phosphorylation prevents|nmod|END_ENTITY	Mdm-2 phosphorylation by DNA-dependent_protein_kinase prevents interaction with p53 .
12145204	0	Mdm2	93,97	Akt	81,84	Mdm2	Akt	4193	207	Gene	Gene	E3|compound|START_ENTITY ligase|nsubj|E3 require|xcomp|ligase require|nsubj|ubiquitylation ubiquitylation|nmod|androgen_receptor androgen_receptor|nmod|END_ENTITY	Phosphorylation-dependent ubiquitylation and degradation of androgen_receptor by Akt require Mdm2 E3 ligase .
17107963	1	Mdm2	68,72	Akt	111,114	Mdm2	Akt	314856(Tax:10116)	24185(Tax:10116)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Mdm2 is activated in response to inhibited Akt signaling .
12488444	0	Mdm2	93,97	Beta-arrestin_2	0,15	Mdm2	Beta-arrestin 2	4193	409	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Beta-arrestin_2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2 .
16845383	0	Mdm2	37,41	Daxx	18,22	Mdm2	Daxx	17246(Tax:10090)	13163(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Critical role for Daxx in regulating Mdm2 .
20153724	0	Mdm2	34,38	Daxx	0,4	Mdm2	Daxx	4193	1616	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Daxx is reciprocally regulated by Mdm2 and Hausp .
10827196	0	Mdm2	16,20	Hdmx	0,4	Mdm2	Hdmx	4193	4193	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Hdmx stabilizes Mdm2 and p53 .
10027414	0	Mdm2	37,41	Insulin-like_growth_factor-1	0,28	Mdm2	Insulin-like growth factor-1	4193	3479	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 induces Mdm2 and down-regulates p53 , attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis .
17170761	0	Mdm2	0,4	JMY	44,47	Mdm2	JMY	17246(Tax:10090)	57748(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Mdm2 targets the p53 transcription cofactor JMY for degradation .
11297540	0	Mdm2	28,32	MdmX	0,4	Mdm2	MdmX	4193	4194	Gene	Gene	stability|amod|START_ENTITY affects|dobj|stability affects|nsubj|binding binding|compound|END_ENTITY	MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation .
12393902	0	Mdm2	76,80	MdmX	0,4	Mdm2	MdmX	4193	4194	Gene	Gene	ubiquitination|amod|START_ENTITY enhancing|dobj|ubiquitination capable|advcl|enhancing ligase|amod|capable ligase|nsubj|END_ENTITY	MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination .
15735705	0	Mdm2	76,80	MdmX	19,23	Mdm2	MdmX	4193	4194	Gene	Gene	export|nmod|START_ENTITY required|nmod|export required|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of MdmX by CDK2/Cdc2 -LRB- p34 -RRB- is required for nuclear export of Mdm2 .
15876864	0	Mdm2	27,31	MdmX	0,4	Mdm2	MdmX	4193	4194	Gene	Gene	sumoylation|amod|START_ENTITY mediated|dobj|sumoylation mediated|nsubj|ARF ARF|compound|END_ENTITY	MdmX inhibits ARF mediated Mdm2 sumoylation .
17301054	0	Mdm2	103,107	MdmX	28,32	Mdm2	MdmX	4193	4194	Gene	Gene	mutants|nmod|START_ENTITY RING|dobj|mutants activity|acl|RING rescues|dobj|activity rescues|nsubj|Hetero-oligomerization Hetero-oligomerization|nmod|END_ENTITY	Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2 .
21572037	0	Mdm2	30,34	MdmX	0,4	Mdm2	MdmX	4193	4194	Gene	Gene	polyubiquitination|amod|START_ENTITY essential|nmod|polyubiquitination essential|nsubj|protein protein|compound|END_ENTITY	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination .
19619542	0	Mdm2	77,81	Mdmx	0,4	Mdm2	Mdmx	4193	4194	Gene	Gene	ligase|amod|START_ENTITY preference|nmod|ligase altering|dobj|preference enhances|advcl|altering enhances|nsubj|END_ENTITY	Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase .
15734743	0	Mdm2	0,4	Nbs1	14,18	Mdm2	Nbs1	4193	4683	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair .
21402876	0	Mdm2	42,46	Notch_4	16,23	Mdm2	Notch 4	4193	4855	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Trp53 regulates Notch_4 signaling through Mdm2 .
25088421	0	Mdm2	16,20	Npas4	0,5	Mdm2	Npas4	4193	266743	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons .
12297306	0	Mdm2	53,57	P14ARF	0,6	Mdm2	P14ARF	4193	1029	Gene	Gene	accumulation|nmod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	P14ARF promotes accumulation of SUMO-1 conjugated -LRB- H -RRB- Mdm2 .
19160491	0	Mdm2	43,47	P53	0,3	Mdm2	P53	4193	7157	Gene	Gene	functions|amod|START_ENTITY controls|nmod|functions controls|nsubj|mRNA mRNA|compound|END_ENTITY	P53 mRNA controls p53 activity by managing Mdm2 functions .
19954744	0	Mdm2	0,4	P53	82,85	Mdm2	P53	4193	7157	Gene	Gene	allele|compound|START_ENTITY displays|nsubj|allele displays|dobj|frequency frequency|nmod|mutations mutations|compound|END_ENTITY	Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular_carcinoma .
15195100	0	Mdm2	44,48	PML	0,3	Mdm2	PML	4193	5371	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PML regulates p53 stability by sequestering Mdm2 to the nucleolus .
11729185	0	Mdm2	23,27	PTEN	0,4	Mdm2	PTEN	4193	5728	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy .
15090541	0	Mdm2	15,19	PTEN	0,4	Mdm2	PTEN	4193	5728	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PTEN regulates Mdm2 expression through the P1 promoter .
20657550	0	Mdm2	36,40	S6K1	0,4	Mdm2	S6K1	4193	6198	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response .
17932951	0	Mdm2	54,58	Ser15	163,168	Mdm2	Ser15	4193	3190208(Tax:176280)	Gene	Gene	phosphorylation|nsubj|START_ENTITY induces|xcomp|phosphorylation induces|advcl|induces induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Anti-diol_epoxide of benzo -LSB- a -RSB- pyrene induces transient Mdm2 and p53 Ser15 phosphorylation , while anti-diol_epoxide of dibenzo -LSB- a , l -RSB- pyrene induces a nontransient p53 Ser15 phosphorylation .
11927554	0	Mdm2	56,60	Tip60	0,5	Mdm2	Tip60	4193	10524	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation .
9400998	0	Mdm2	13,17	bFGF	54,58	Mdm2	bFGF	4193	2247	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of Mdm2 and enhancement of cell survival by bFGF .
10085066	0	Mdm2	43,47	c-Abl	0,5	Mdm2	c-Abl	4193	25	Gene	Gene	effect|nmod|START_ENTITY neutralizes|dobj|effect neutralizes|nsubj|END_ENTITY	c-Abl neutralizes the inhibitory effect of Mdm2 on p53 .
21081495	0	Mdm2	25,29	c-Abl	0,5	Mdm2	c-Abl	17246(Tax:10090)	11350(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation .
26228571	0	Mdm2	21,25	mTOR	78,82	Mdm2	mTOR	4193	21977(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G_protein-coupled_receptor_kinase_2 in the regulation of GPR17 receptor desensitization .
26470726	0	Mdm2	81,85	murine_double_minute_2	57,79	Mdm2	murine double minute 2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Apoptosis of Sertoli cells after conditional ablation of murine_double_minute_2 -LRB- Mdm2 -RRB- gene is p53-dependent and results in male_sterility .
12080472	0	Mdm2	0,4	p21	56,59	Mdm2	p21	17246(Tax:10090)	12575(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY induces|nsubj|inhibition induces|dobj|transactivation transactivation|nmod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
17371838	0	Mdm2	0,4	p21	52,55	Mdm2	p21	4193	644914	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|inhibition inhibition|nmod|activity activity|nmod|END_ENTITY	Mdm2 is required for inhibition of Cdk2 activity by p21 , thereby contributing to p53-dependent cell cycle arrest .
17536310	0	Mdm2	25,29	p21	31,34	Mdm2	p21	4193	1026	Gene	Gene	Immunoreactivity|appos|START_ENTITY Immunoreactivity|appos|Bcl-2 Bcl-2|amod|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
18485798	0	Mdm2	0,4	p21	11,14	Mdm2	p21	4193	644914	Gene	Gene	pathways|advmod|START_ENTITY pathways|nsubj|END_ENTITY	Mdm2 , p53 , p21 and pAKT protein pathways in benign neoplasms of the salivary gland .
10202144	0	Mdm2	74,78	p53	33,36	Mdm2	p53	4193	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|Ser20 Ser20|nmod|END_ENTITY	Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 .
10202144	0	Mdm2	74,78	p53	67,70	Mdm2	p53	4193	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 .
10359817	0	Mdm2	68,72	p53	20,23	Mdm2	p53	4193	7157	Gene	Gene	shuttling|nmod|START_ENTITY blocking|dobj|shuttling stabilizes|advcl|blocking stabilizes|dobj|END_ENTITY	P19 -LRB- ARF -RRB- stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2 .
10781812	0	Mdm2	0,4	p53	55,58	Mdm2	p53	4193	7157	Gene	Gene	START_ENTITY|amod|binding binding|nmod|domain domain|nmod|END_ENTITY	Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA .
10889922	0	Mdm2	20,24	p53	92,95	Mdm2	p53	4193	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|status status|compound|END_ENTITY	Immunohistochemical Mdm2 expression in minor salivary_gland_tumours and its relationship to p53 gene status .
10892746	0	Mdm2	75,79	p53	104,107	Mdm2	p53	4193	7157	Gene	Gene	ability|amod|START_ENTITY increases|dobj|ability increases|nmod|END_ENTITY	SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53 .
10980197	0	Mdm2	0,4	p53	40,43	Mdm2	p53	4193	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation .
11003613	0	Mdm2	79,83	p53	16,19	Mdm2	p53	314856(Tax:10116)	301300(Tax:10116)	Gene	Gene	accompanied|nmod|START_ENTITY accompanied|nsubjpass|Loss Loss|nmod|protein protein|compound|END_ENTITY	Loss of nuclear p53 protein in preneoplastic rat hepatocytes is accompanied by Mdm2 and Bcl-2 overexpression and by defective response to DNA damage in vivo .
11053443	0	Mdm2	62,66	p53	37,40	Mdm2	p53	4193	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|domain domain|nmod|END_ENTITY	A role for the polyproline domain of p53 in its regulation by Mdm2 .
11158620	0	Mdm2	21,25	p53	77,80	Mdm2	p53	4193	7157	Gene	Gene	switch|nmod|START_ENTITY switch|nmod|END_ENTITY	Complete switch from Mdm2 to human_papillomavirus E6-mediated degradation of p53 in cervical_cancer cells .
11328884	0	Mdm2	66,70	p53	111,114	Mdm2	p53	4193	7157	Gene	Gene	promoter|amod|START_ENTITY site|nmod|promoter Binding|dobj|site alleviates|csubj|Binding alleviates|dobj|requirement requirement|nmod|activation activation|compound|END_ENTITY	Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation .
11328884	0	Mdm2	66,70	p53	42,45	Mdm2	p53	4193	7157	Gene	Gene	promoter|amod|START_ENTITY site|nmod|promoter Binding|dobj|site Binding|nmod|END_ENTITY	Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation .
11331603	0	Mdm2	33,37	p53	61,64	Mdm2	p53	4193	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|dep|role role|nmod|activation activation|compound|END_ENTITY	ATM-dependent phosphorylation of Mdm2 on serine 395 : role in p53 activation by DNA damage .
11532197	0	Mdm2	116,120	p53	73,76	Mdm2	p53	4193	7157	Gene	Gene	levels|amod|START_ENTITY decreasing|dobj|levels increased|advcl|decreasing increased|dobj|activity activity|nummod|END_ENTITY	HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels .
11707453	0	Mdm2	118,122	p53	47,50	Mdm2	p53	4193	7157	Gene	Gene	binds|nmod|START_ENTITY domain|acl:relcl|binds Regulation|nmod|domain Regulation|nmod|accumulation accumulation|nmod|END_ENTITY	Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2 .
11729185	0	Mdm2	23,27	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	protects|nmod|START_ENTITY protects|dobj|END_ENTITY	PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy .
12080472	0	Mdm2	0,4	p53	19,22	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
12110584	0	Mdm2	28,32	p53	60,63	Mdm2	p53	4193	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|dep|implications implications|nmod|regulation regulation|compound|END_ENTITY	Tyrosine phosphorylation of Mdm2 by c-Abl : implications for p53 regulation .
12167711	0	Mdm2	23,27	p53	37,40	Mdm2	p53	4193	7157	Gene	Gene	Hypophosphorylation|nmod|START_ENTITY augments|nsubj|Hypophosphorylation augments|dobj|stability stability|compound|END_ENTITY	Hypophosphorylation of Mdm2 augments p53 stability .
12217521	0	Mdm2	10,14	p53	16,19	Mdm2	p53	4193	7157	Gene	Gene	PTEN|appos|START_ENTITY PTEN|appos|tumor tumor|compound|END_ENTITY	The PTEN , Mdm2 , p53 tumor suppressor-oncoprotein network .
12383858	0	Mdm2	44,48	p53	73,76	Mdm2	p53	4193	7157	Gene	Gene	oncoprotein|amod|START_ENTITY oncoprotein|acl:relcl|affect affect|dobj|degradation degradation|compound|END_ENTITY	Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation .
12421820	0	Mdm2	50,54	p53	15,18	Mdm2	p53	4193	7157	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|Acetylation Acetylation|nmod|END_ENTITY	Acetylation of p53 inhibits its ubiquitination by Mdm2 .
12552135	0	Mdm2	48,52	p53	71,74	Mdm2	p53	4193	7157	Gene	Gene	domain|nmod|START_ENTITY lid|nmod|domain lid|dep|implications implications|nmod|regulation regulation|compound|END_ENTITY	Flexible lid to the p53-binding domain of human Mdm2 : implications for p53 regulation .
12586367	0	Mdm2	44,48	p53	37,40	Mdm2	p53	4193	7157	Gene	Gene	Differences|nmod|START_ENTITY Differences|nmod|ubiquitination ubiquitination|nmod|END_ENTITY	Differences in the ubiquitination of p53 by Mdm2 and the HPV protein E6 .
12600196	0	Mdm2	18,22	p53	55,58	Mdm2	p53	4193	7157	Gene	Gene	proteins|compound|START_ENTITY Overexpression|nmod|proteins alters|nsubj|Overexpression alters|ccomp|mediated mediated|nsubj|END_ENTITY	Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation , ubiquitination , and degradation .
12832478	0	Mdm2	36,40	p53	66,69	Mdm2	p53	4193	7157	Gene	Gene	START_ENTITY|nmod|ubiquitylation ubiquitylation|nmod|END_ENTITY	Critical role for a central part of Mdm2 in the ubiquitylation of p53 .
12926050	0	Mdm2	0,4	p53	82,85	Mdm2	p53	4193	7157	Gene	Gene	mutants|amod|START_ENTITY act|nsubj|mutants act|nmod|END_ENTITY	Mdm2 ligase dead mutants did not act in a dominant negative manner to re-activate p53 , but promoted tumor cell growth .
14522887	0	Mdm2	19,23	p53	55,58	Mdm2	p53	4193	7157	Gene	Gene	splice|amod|START_ENTITY promotion|nmod|splice variants|nsubj|promotion variants|xcomp|unable unable|nmod|END_ENTITY	Tumor promotion by Mdm2 splice variants unable to bind p53 .
14654783	0	Mdm2	19,23	p53	65,68	Mdm2	p53	4193	7157	Gene	Gene	role|nmod|START_ENTITY phosphorylation|nsubj|role phosphorylation|nmod|attenuation attenuation|nmod|export export|compound|END_ENTITY	Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export .
14671306	0	Mdm2	69,73	p53	57,60	Mdm2	p53	4193	7157	Gene	Gene	fate|nmod|START_ENTITY control|acl|fate control|nmod|END_ENTITY	Mono - versus polyubiquitination : differential control of p53 fate by Mdm2 .
14673154	0	Mdm2	0,4	p53	15,18	Mdm2	p53	4193	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Mdm2 regulates p53 independently of p19 -LRB- ARF -RRB- in homeostatic tissues .
15013777	0	Mdm2	33,37	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	acetylation|amod|START_ENTITY Inhibition|nmod|acetylation Inhibition|nmod|degradation degradation|compound|END_ENTITY	Inhibition of p53 degradation by Mdm2 acetylation .
15150125	0	Mdm2	51,55	p53	21,24	Mdm2	p53	4193	7157	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
15150125	0	Mdm2	51,55	p53	86,89	Mdm2	p53	4193	7157	Gene	Gene	inhibition|nmod|START_ENTITY p53|nmod|inhibition induces|dobj|p53 induces|dep|END_ENTITY	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
15195100	0	Mdm2	44,48	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|stability stability|compound|END_ENTITY	PML regulates p53 stability by sequestering Mdm2 to the nucleolus .
15242638	0	Mdm2	26,30	p53	65,68	Mdm2	p53	4193	7157	Gene	Gene	catalyzed|nsubj|START_ENTITY catalyzed|nmod|END_ENTITY	Neddylating the guardian ; Mdm2 catalyzed conjugation of Nedd8 to p53 .
15337531	0	Mdm2	81,85	p53	130,133	Mdm2	p53	4193	7157	Gene	Gene	activation|nmod|START_ENTITY activation|dep|mechanisms mechanisms|acl:relcl|increase increase|dobj|function function|compound|END_ENTITY	Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2 : two mechanisms that cooperatively increase p53 function in colon_cancer cells .
15337531	0	Mdm2	81,85	p53	54,57	Mdm2	p53	4193	7157	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2 : two mechanisms that cooperatively increase p53 function in colon_cancer cells .
15782125	0	Mdm2	0,4	p53	55,58	Mdm2	p53	4193	7157	Gene	Gene	prevent|nsubj|START_ENTITY prevent|advcl|stimulating stimulating|dobj|END_ENTITY	Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation .
15782125	0	Mdm2	0,4	p53	77,80	Mdm2	p53	4193	7157	Gene	Gene	prevent|nsubj|START_ENTITY prevent|advcl|stimulating stimulating|advcl|targeting targeting|dobj|END_ENTITY	Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation .
16055726	0	Mdm2	56,60	p53	71,74	Mdm2	p53	4193	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|abundance abundance|compound|END_ENTITY	Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance .
16354690	0	Mdm2	49,53	p53	31,34	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|differences differences|nmod|END_ENTITY	Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4 .
16455486	0	Mdm2	20,24	p53	0,3	Mdm2	p53	4193	7157	Gene	Gene	ubiquitination|dep|START_ENTITY ubiquitination|compound|END_ENTITY	p53 ubiquitination : Mdm2 and beyond .
16492743	0	Mdm2	21,25	p53	39,42	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|inhibition inhibition|compound|END_ENTITY	Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development .
16866370	0	Mdm2	51,55	p53	73,76	Mdm2	p53	4193	7157	Gene	Gene	domain|nmod|START_ENTITY site|nmod|domain essential|nsubj|site essential|nmod|ubiquitination ubiquitination|compound|END_ENTITY	A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination .
16866370	0	Mdm2	51,55	p53	9,12	Mdm2	p53	4193	7157	Gene	Gene	domain|nmod|START_ENTITY site|nmod|domain site|compound|END_ENTITY	A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination .
16870621	0	Mdm2	40,44	p53	11,14	Mdm2	p53	4193	7157	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation .
17056014	0	Mdm2	66,70	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	interaction|amod|START_ENTITY agents|nmod|interaction induced|nmod|agents response|acl|induced response|compound|END_ENTITY	KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction .
17086174	0	Mdm2	67,71	p53	50,53	Mdm2	p53	4193	7157	Gene	Gene	self-ubiquitination|amod|START_ENTITY promoting|dobj|self-ubiquitination regulates|advcl|promoting regulates|dobj|END_ENTITY	SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination .
17170761	0	Mdm2	0,4	p53	17,20	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|JMY JMY|compound|END_ENTITY	Mdm2 targets the p53 transcription cofactor JMY for degradation .
17290220	0	Mdm2	73,77	p53	48,51	Mdm2	p53	4193	7157	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|pathway pathway|compound|END_ENTITY	The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 .
17386256	0	Mdm2	0,4	p53	6,9	Mdm2	p53	4193	7157	Gene	Gene	START_ENTITY|dep|lifesaver lifesaver|nmod:poss|END_ENTITY	Mdm2 : p53 's lifesaver ?
17525743	0	Mdm2	9,13	p53	44,47	Mdm2	p53	4193	7157	Gene	Gene	p53|dep|START_ENTITY HAUSP|nsubj|p53 HAUSP|ccomp|involved involved|nmod|stabilization stabilization|compound|END_ENTITY	The p53 -- Mdm2 -- HAUSP complex is involved in p53 stabilization by HAUSP .
17536310	0	Mdm2	25,29	p53	20,23	Mdm2	p53	4193	7157	Gene	Gene	Immunoreactivity|appos|START_ENTITY Immunoreactivity|nmod|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
17585950	0	Mdm2	59,63	p53	37,40	Mdm2	p53	4193	7157	Gene	Gene	ubiquitination|nmod|START_ENTITY ubiquitination|nsubj|switch switch|nmod|auto auto|nmod|END_ENTITY	HAUSP-regulated switch from auto - to p53 ubiquitination by Mdm2 -LRB- in silico discovery -RRB- .
17932951	0	Mdm2	54,58	p53	159,162	Mdm2	p53	4193	7157	Gene	Gene	phosphorylation|nsubj|START_ENTITY induces|xcomp|phosphorylation induces|advcl|induces induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Anti-diol_epoxide of benzo -LSB- a -RSB- pyrene induces transient Mdm2 and p53 Ser15 phosphorylation , while anti-diol_epoxide of dibenzo -LSB- a , l -RSB- pyrene induces a nontransient p53 Ser15 phosphorylation .
17936560	0	Mdm2	25,29	p53	118,121	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY inactivation|nmod|activity reveals|nsubj|inactivation reveals|nmod|regulation regulation|compound|END_ENTITY	Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation .
18483220	0	Mdm2	56,60	p53	35,38	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	alleviated|nmod|START_ENTITY alleviated|nsubjpass|instability instability|nmod|END_ENTITY	The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss .
18485798	0	Mdm2	0,4	p53	6,9	Mdm2	p53	4193	7157	Gene	Gene	pathways|advmod|START_ENTITY pathways|nsubj|p21 p21|compound|END_ENTITY	Mdm2 , p53 , p21 and pAKT protein pathways in benign neoplasms of the salivary gland .
18541670	0	Mdm2	0,4	p53	68,71	Mdm2	p53	4193	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|instability instability|nmod|END_ENTITY	Mdm2 promotes genetic instability and transformation independent of p53 .
18548093	0	Mdm2	68,72	p53	51,54	Mdm2	p53	4193	7157	Gene	Gene	inhibition|amod|START_ENTITY prevents|nmod|inhibition prevents|dobj|induction induction|compound|END_ENTITY	The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML .
18567799	0	Mdm2	0,4	p53	38,41	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activities activities|compound|END_ENTITY	Mdm2 and Mdm4 loss regulates distinct p53 activities .
18951086	0	Mdm2	0,4	p53	15,18	Mdm2	p53	4193	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|translation translation|compound|END_ENTITY	Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal_protein_L26 .
19160491	0	Mdm2	43,47	p53	18,21	Mdm2	p53	4193	7157	Gene	Gene	functions|amod|START_ENTITY controls|nmod|functions controls|dobj|activity activity|compound|END_ENTITY	P53 mRNA controls p53 activity by managing Mdm2 functions .
19217357	0	Mdm2	22,26	p53	0,3	Mdm2	p53	4193	7157	Gene	Gene	ubiquitination|nmod|START_ENTITY ubiquitination|nsubj|END_ENTITY	p53 ubiquitination by Mdm2 : a never ending tail ?
19244108	0	Mdm2	0,4	p53	45,48	Mdm2	p53	4193	7157	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|independent independent|nmod|END_ENTITY	Mdm2 affects genome stability independent of p53 .
19305137	0	Mdm2	65,69	p53	33,36	Mdm2	p53	4193	7157	Gene	Gene	peptide-analogue|nmod|START_ENTITY peptide-analogue|nsubj|interaction interaction|nmod|END_ENTITY	High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx .
19619542	0	Mdm2	77,81	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	ligase|amod|START_ENTITY preference|nmod|ligase altering|dobj|preference enhances|advcl|altering enhances|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase .
20172729	0	Mdm2	19,23	p53	4,7	Mdm2	p53	4193	7157	Gene	Gene	set|nsubj|START_ENTITY orchestra|parataxis|set orchestra|compound|END_ENTITY	The p53 orchestra : Mdm2 and Mdmx set the tone .
20479273	0	Mdm2	0,4	p53	36,39	Mdm2	p53	4193	7157	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|association association|nmod|END_ENTITY	Mdm2 facilitates the association of p53 with the proteasome .
20528739	0	Mdm2	86,90	p53	18,21	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	function|nmod:poss|START_ENTITY studying|dobj|function problems|acl|studying Regulation|dep|problems Regulation|nmod|pathway pathway|compound|END_ENTITY	Regulation of the p53 tumor suppressor pathway : the problems and promises of studying Mdm2 's E3 ligase function .
20812030	0	Mdm2	0,4	p53	37,40	Mdm2	p53	4193	7157	Gene	Gene	inhibition|amod|START_ENTITY induces|nsubj|inhibition induces|dobj|apoptosis apoptosis|nmod|cells cells|nummod|END_ENTITY	Mdm2 inhibition induces apoptosis in p53 deficient human colon_cancer cells by activating p73 - and E2F1-mediated expression of PUMA and Siva-1 .
21040902	0	Mdm2	0,4	p53	99,102	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|survival survival|nmod|cells/progenitors cells/progenitors|nmod|dampening dampening|nmod|activity activity|compound|END_ENTITY	Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity .
21088494	0	Mdm2	26,30	p53	67,70	Mdm2	p53	4193	7157	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of regulators Mdm2 and Mdmx with transcription factors p53 , p63 and p73 .
21211512	0	Mdm2	60,64	p53	102,105	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY maintains|dobj|expression maintains|parataxis|signaling signaling|nsubj|implication implication|nmod|regulation regulation|nmod|END_ENTITY	Transcription factor Nrf2 maintains the basal expression of Mdm2 : An implication of the regulation of p53 signaling by Nrf2 .
21213101	0	Mdm2	0,4	p53	46,49	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	Mdm2 links genotoxic stress and metabolism to p53 .
21217645	0	Mdm2	48,52	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	loop|amod|START_ENTITY joins|dobj|loop joins|dobj|network network|compound|END_ENTITY	miR-605 joins p53 network to form a p53 : miR-605 : Mdm2 positive feedback loop in response to stress .
21217645	0	Mdm2	48,52	p53	36,39	Mdm2	p53	4193	7157	Gene	Gene	loop|amod|START_ENTITY joins|dobj|loop joins|xcomp|form form|dobj|END_ENTITY	miR-605 joins p53 network to form a p53 : miR-605 : Mdm2 positive feedback loop in response to stress .
21420949	0	Mdm2	36,40	p53	20,23	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching .
21572037	0	Mdm2	30,34	p53	52,55	Mdm2	p53	4193	7157	Gene	Gene	polyubiquitination|amod|START_ENTITY polyubiquitination|compound|END_ENTITY	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination .
21730132	0	Mdm2	22,26	p53	63,66	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	Heterodimerization|nmod|START_ENTITY critical|nsubj|Heterodimerization critical|advcl|regulating regulating|dobj|activity activity|compound|END_ENTITY	Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability .
21762075	0	Mdm2	34,38	p53	16,19	Mdm2	p53	4193	7157	Gene	Gene	E3|compound|START_ENTITY ligase|nsubj|E3 inhibiting|xcomp|ligase END_ENTITY|acl|inhibiting	Reactivation of p53 by inhibiting Mdm2 E3 ligase : a novel antitumor approach .
22134240	0	Mdm2	49,53	p53	0,3	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	domains|nmod|START_ENTITY RING|dobj|domains teamwork|acl|RING regulation|dep|teamwork regulation|compound|END_ENTITY	p53 regulation : teamwork between RING domains of Mdm2 and MdmX .
22148351	0	Mdm2	46,50	p53	25,28	Mdm2	p53	4193	7157	Gene	Gene	bound|nmod|START_ENTITY peptide|xcomp|bound peptide|nsubj|Structure Structure|nmod|END_ENTITY	Structure of the stapled p53 peptide bound to Mdm2 .
22197810	0	Mdm2	0,4	p53	70,73	Mdm2	p53	4193	7157	Gene	Gene	activator|nsubj|START_ENTITY activator|acl:relcl|antagonized antagonized|nmod|inhibition inhibition|compound|END_ENTITY	Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition .
22264786	0	Mdm2	39,43	p53	4,7	Mdm2	p53	4193	7157	Gene	Gene	trafficking|amod|START_ENTITY controls|dobj|trafficking controls|nsubj|interaction interaction|compound|END_ENTITY	The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage .
22301280	0	Mdm2	30,34	p53	63,66	Mdm2	p53	4193	7157	Gene	Gene	RING|amod|START_ENTITY bind|dobj|RING molecules|acl:relcl|bind stabilize|nsubj|molecules stabilize|dobj|END_ENTITY	Small molecules that bind the Mdm2 RING stabilize and activate p53 .
22333590	0	Mdm2	103,107	p53	124,127	Mdm2	p53	4193	7157	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers .
22333590	0	Mdm2	23,27	p53	124,127	Mdm2	p53	4193	7157	Gene	Gene	tail|amod|START_ENTITY analysis|nmod|tail suggests|nsubj|analysis suggests|nmod|activity activity|nmod|END_ENTITY	Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers .
22410433	0	Mdm2	43,47	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	collaboration|nmod|START_ENTITY Regulation|dep|collaboration Regulation|nmod|END_ENTITY	Regulation of p53 : a collaboration between Mdm2 and Mdmx .
22487680	0	Mdm2	48,52	p53	4,7	Mdm2	p53	4193	7157	Gene	Gene	modified|nmod|START_ENTITY modified|nsubjpass|isoforms isoforms|compound|END_ENTITY	The p53 isoforms are differentially modified by Mdm2 .
22659184	0	Mdm2	43,47	p53	83,86	Mdm2	p53	4193	7157	Gene	Gene	domain|amod|START_ENTITY domain|nmod|regulation regulation|nmod|stability stability|compound|END_ENTITY	Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability .
22666487	0	Mdm2	0,4	p53	28,31	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY enhances|nsubj|mutation enhances|dobj|activity activity|compound|END_ENTITY	Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction .
22673503	0	Mdm2	0,4	p53	34,37	Mdm2	p53	4193	7157	Gene	Gene	partner|compound|START_ENTITY partner|acl|regulate regulate|dobj|END_ENTITY	Mdm2 and MdmX partner to regulate p53 .
24476585	0	Mdm2	139,143	p53	130,133	Mdm2	p53	4193	7157	Gene	Gene	targeting|nmod|START_ENTITY targeting|dobj|interaction interaction|nmod|END_ENTITY	The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells : targeting the interaction of p53 with Mdm2 and Mdm4 .
25117711	0	Mdm2	21,25	p53	14,17	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	function|compound|START_ENTITY END_ENTITY|nmod|function	Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development , but essential in response to DNA damage .
25486483	0	Mdm2	155,159	p53	104,107	Mdm2	p53	4193	7157	Gene	Gene	signaling|nsubj|START_ENTITY functions|parataxis|signaling functions|nmod|suppressor suppressor|nmod|gastric_cancer gastric_cancer|nmod|END_ENTITY	Epithelial cell-derived periostin functions as a tumor suppressor in gastric_cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF / Mdm2 signaling pathway .
25637791	0	Mdm2	62,66	p53	34,37	Mdm2	p53	4193	7157	Gene	Gene	activity|amod|START_ENTITY regulating|dobj|activity decreases|advcl|regulating decreases|dobj|stability stability|compound|END_ENTITY	Heat_shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver_cancer .
25746004	0	Mdm2	47,51	p53	28,31	Mdm2	p53	30637(Tax:7955)	30590(Tax:7955)	Gene	Gene	inactivation|amod|START_ENTITY mimicked|nmod|inactivation mimicked|nsubjpass|Tumor-specific Tumor-specific|acl|signaling signaling|nmod|END_ENTITY	Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish : insights from mdm2 and mdm4 mutant zebrafish .
9153395	0	Mdm2	0,4	p53	39,42	Mdm2	p53	4193	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Mdm2 promotes the rapid degradation of p53 .
9153396	0	Mdm2	31,35	p53	14,17	Mdm2	p53	4193	7157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|stability stability|compound|END_ENTITY	Regulation of p53 stability by Mdm2 .
9458382	0	Mdm2	35,39	p53	65,68	Mdm2	p53	4193	7157	Gene	Gene	detection|amod|START_ENTITY relevance|nmod|detection enhanced|nsubjpass|relevance enhanced|nmod|positivity positivity|compound|END_ENTITY	Prognostic relevance of C-terminal Mdm2 detection is enhanced by p53 positivity in soft tissue_sarcomas .
9824166	0	Mdm2	0,4	p53	22,25	Mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Mdm2 association with p53 targets its ubiquitination .
9878046	0	Mdm2	29,33	p53	98,101	Mdm2	p53	4193	7157	Gene	Gene	p19|nmod|START_ENTITY Association|nmod|p19 inhibits|nsubj|Association inhibits|dobj|activity activity|nmod|Mdm2 Mdm2|nmod|END_ENTITY	Association of p19 -LRB- ARF -RRB- with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 .
11445003	0	Mdm2	30,34	p63	14,17	Mdm2	p63	4193	8626	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of p63 function by Mdm2 and MdmX .
11297540	0	MdmX	0,4	Mdm2	28,32	MdmX	Mdm2	4194	4193	Gene	Gene	binding|compound|START_ENTITY affects|nsubj|binding affects|dobj|stability stability|amod|END_ENTITY	MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation .
12393902	0	MdmX	0,4	Mdm2	76,80	MdmX	Mdm2	4194	4193	Gene	Gene	ligase|nsubj|START_ENTITY ligase|amod|capable capable|advcl|enhancing enhancing|dobj|ubiquitination ubiquitination|amod|END_ENTITY	MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination .
15735705	0	MdmX	19,23	Mdm2	76,80	MdmX	Mdm2	4194	4193	Gene	Gene	Phosphorylation|nmod|START_ENTITY required|nsubjpass|Phosphorylation required|nmod|export export|nmod|END_ENTITY	Phosphorylation of MdmX by CDK2/Cdc2 -LRB- p34 -RRB- is required for nuclear export of Mdm2 .
15876864	0	MdmX	0,4	Mdm2	27,31	MdmX	Mdm2	4194	4193	Gene	Gene	ARF|compound|START_ENTITY mediated|nsubj|ARF mediated|dobj|sumoylation sumoylation|amod|END_ENTITY	MdmX inhibits ARF mediated Mdm2 sumoylation .
17301054	0	MdmX	28,32	Mdm2	103,107	MdmX	Mdm2	4194	4193	Gene	Gene	Hetero-oligomerization|nmod|START_ENTITY rescues|nsubj|Hetero-oligomerization rescues|dobj|activity activity|acl|RING RING|dobj|mutants mutants|nmod|END_ENTITY	Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2 .
21572037	0	MdmX	0,4	Mdm2	30,34	MdmX	Mdm2	4194	4193	Gene	Gene	protein|compound|START_ENTITY essential|nsubj|protein essential|nmod|polyubiquitination polyubiquitination|amod|END_ENTITY	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination .
10629057	0	MdmX	0,4	p53	14,17	MdmX	p53	4194	7157	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	MdmX protects p53 from Mdm2-mediated degradation .
16227609	0	MdmX	38,42	p53	67,70	MdmX	p53	4194	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY activates|nsubj|phosphorylation activates|dobj|END_ENTITY	DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation .
16227609	0	MdmX	84,88	p53	67,70	MdmX	p53	4194	7157	Gene	Gene	targeting|dobj|START_ENTITY activates|advcl|targeting activates|dobj|END_ENTITY	DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation .
19153082	0	MdmX	28,32	p53	56,59	MdmX	p53	4194	7157	Gene	Gene	Structures|nmod|START_ENTITY Structures|nmod|Complex Complex|nmod|Changes Changes|nummod|END_ENTITY	Crystal Structures of Human MdmX -LRB- HdmX -RRB- in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes .
20174603	0	MdmX	23,27	p53	59,62	MdmX	p53	4194	7157	Gene	Gene	functions|nmod|START_ENTITY fine-tuning|nsubj|functions fine-tuning|dobj|response response|nmod|END_ENTITY	Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage .
21572037	0	MdmX	0,4	p53	52,55	MdmX	p53	4194	7157	Gene	Gene	protein|compound|START_ENTITY essential|nsubj|protein essential|nmod|polyubiquitination polyubiquitination|compound|END_ENTITY	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination .
21852537	0	MdmX	14,18	p53	60,63	MdmX	p53	17248(Tax:10090)	22060(Tax:10090)	Gene	Gene	Validation|nmod|START_ENTITY Validation|nmod|END_ENTITY	Validation of MdmX as a therapeutic target for reactivating p53 in tumors .
22290440	0	MdmX	0,4	p53	21,24	MdmX	p53	4194	7157	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|interaction interaction|compound|END_ENTITY	MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress .
22989451	0	MdmX	104,108	p53	114,117	MdmX	p53	4194	7157	Gene	Gene	interaction|nmod|START_ENTITY inhibit|dobj|interaction inhibit|nmod|END_ENTITY	A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53 .
16510145	0	MdmX	11,15	pRB	51,54	MdmX	pRB	4194	5925	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of MdmX on Mdm2-mediated downregulation of pRB .
19619542	0	Mdmx	0,4	Mdm2	77,81	Mdmx	Mdm2	4194	4193	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|altering altering|dobj|preference preference|nmod|ligase ligase|amod|END_ENTITY	Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase .
11606419	0	Mdmx	0,4	p53	16,19	Mdmx	p53	4194	7157	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms .
15199139	0	Mdmx	17,21	p53	86,89	Mdmx	p53	4194	7157	Gene	Gene	Amplification|nmod|START_ENTITY contributes|nsubj|Amplification contributes|advcl|inhibiting inhibiting|dobj|activity activity|compound|END_ENTITY	Amplification of Mdmx -LRB- or Mdm4 -RRB- directly contributes to tumor formation by inhibiting p53 tumor suppressor activity .
15865931	0	Mdmx	0,4	p53	34,37	Mdmx	p53	17248(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Mdmx as an essential regulator of p53 activity .
17938582	0	Mdmx	45,49	p53	38,41	Mdmx	p53	4194	7157	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|inhibition inhibition|nmod|END_ENTITY	Molecular basis for the inhibition of p53 by Mdmx .
18677113	0	Mdmx	23,27	p53	49,52	Mdmx	p53	4194	7157	Gene	Gene	protein|compound|START_ENTITY Structure|nmod|protein bound|nsubj|Structure bound|nmod|domain domain|compound|END_ENTITY	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain .
19432880	0	Mdmx	70,74	p53	63,66	Mdmx	p53	4194	7157	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|inhibition inhibition|nmod|END_ENTITY	Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2 .
19619542	0	Mdmx	0,4	p53	14,17	Mdmx	p53	4194	7157	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase .
23277204	0	Mdmx	82,86	p53	31,34	Mdmx	p53	4194	7157	Gene	Gene	dephosphorylating|dobj|START_ENTITY signaling|advcl|dephosphorylating END_ENTITY|acl|signaling	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx .
24608433	0	Mdmx	0,4	p53	49,52	Mdmx	p53	4194	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|independent independent|nmod|END_ENTITY	Mdmx promotes genomic instability independent of p53 and Mdm2 .
24667108	0	Mdmx	17,21	p53	106,109	Mdmx	p53	4194	7157	Gene	Gene	Amplification|nmod|START_ENTITY contribute|nsubj|Amplification contribute|xcomp|mammary mammary|advcl|substituting substituting|nmod|mutations mutations|compound|END_ENTITY	Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations .
26181202	0	Mdmx	10,14	p53	54,57	Mdmx	p53	4194	7157	Gene	Gene	Targeting|dobj|START_ENTITY Targeting|xcomp|treat treat|nmod|END_ENTITY	Targeting Mdmx to treat breast_cancers with wild-type p53 .
20557448	0	Mdr1	78,82	P-glycoprotein	62,76	Mdr1	P-glycoprotein	443367(Tax:9940)	443367(Tax:9940)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cloning and heterologous expression of the ovine -LRB- Ovis_aries -RRB- P-glycoprotein -LRB- Mdr1 -RRB- in Madin-Darby canine kidney -LRB- MDCK -RRB- cells .
8678896	0	Mdr1	97,101	multidrug_resistance	75,95	Mdr1	multidrug resistance	5243	5243	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Expression of the low-density_lipoprotein_receptor , HMG-CoA_reductase , and multidrug_resistance -LRB- Mdr1 -RRB- genes in colorectal_carcinomas .
17356567	0	Mdr1	51,55	p-glycoprotein	62,76	Mdr1	p-glycoprotein	18669(Tax:10090)	67078(Tax:10090)	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|dep|END_ENTITY	The antidepressant desipramine requires the ABCB1 -LRB- Mdr1 -RRB- - type p-glycoprotein to upregulate the glucocorticoid receptor in mice .
10880020	0	Mdr1	0,4	tumor_necrosis_factor-alpha	21,48	Mdr1	tumor necrosis factor-alpha	5243	7124	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Mdr1 promoter-driven tumor_necrosis_factor-alpha expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors .
16545584	0	Mdr1a	88,93	P-glycoprotein	114,128	Mdr1a	P-glycoprotein	170913(Tax:10116)	5243	Gene	Gene	Abcb1a|appos|START_ENTITY containing|dobj|Abcb1a cells|acl|containing Development|nmod|cells Development|dep|comparison comparison|nmod|transport transport|amod|END_ENTITY	Development and characterization of LLC-PK1 cells containing Sprague-Dawley_rat Abcb1a -LRB- Mdr1a -RRB- : comparison of rat P-glycoprotein transport to human and mouse .
9580581	0	Mdr1a	14,19	P-glycoprotein	20,34	Mdr1a	P-glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	disruption|amod|START_ENTITY disruption|amod|END_ENTITY	Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ_PSC_833 , a multidrug resistance-reversing agent , in mice .
26194248	0	Mdr1b	32,37	ABCB1	38,43	Mdr1b	ABCB1	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	Genes|compound|START_ENTITY Genes|compound|END_ENTITY	Effect of Knockout of Mdr1a and Mdr1b ABCB1 Genes on the Systemic Exposure of a Doxorubicin-Conjugated Block Copolymer in Mice .
12381268	0	Mdr2	108,112	multidrug_resistance_2	84,106	Mdr2	multidrug resistance 2	18670(Tax:10090)	18670(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- - mediated regulation of multidrug_resistance_2 -LRB- Mdr2 -RRB- expression and function in mice .
15024067	0	Mdt1	0,4	Rad53	14,19	Mdt1	Rad53	852229(Tax:4932)	855950(Tax:4932)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Mdt1 , a novel Rad53 FHA1 domain-interacting protein , modulates DNA damage tolerance and G -LRB- 2 -RRB- / M cell cycle progression in Saccharomyces_cerevisiae .
14593183	0	MeCP2	81,86	BDNF	16,20	MeCP2	BDNF	17257(Tax:10090)	12064(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY involves|dobj|phosphorylation involves|nsubj|Derepression Derepression|nmod|transcription transcription|compound|END_ENTITY	Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 .
14988922	0	MeCP2	93,98	BDNF	74,78	MeCP2	BDNF	4204	627	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Dynamic regulation of DNA methylation coupled transcriptional repression : BDNF regulation by MeCP2 .
18075316	0	MeCP2	0,5	BDNF	40,44	MeCP2	BDNF	4204	627	Gene	Gene	deficiency_in_the_brain|amod|START_ENTITY decreases|nsubj|deficiency_in_the_brain decreases|dobj|levels levels|amod|END_ENTITY	MeCP2 deficiency_in_the_brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production .
20711185	0	MeCP2	0,5	BDNF	15,19	MeCP2	BDNF	4204	627	Gene	Gene	controls|amod|START_ENTITY END_ENTITY|nsubj|controls	MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212 .
22677942	0	MeCP2	32,37	BDNF	53,57	MeCP2	BDNF	4204	627	Gene	Gene	deacetylation|nmod|START_ENTITY contributes|nsubj|deacetylation contributes|xcomp|END_ENTITY	SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression .
25579386	0	MeCP2	104,109	BDNF	65,69	MeCP2	BDNF	4204	627	Gene	Gene	Protein|appos|START_ENTITY Brain-Derived_Neurotrophic_Factor|nmod|Protein Brain-Derived_Neurotrophic_Factor|appos|END_ENTITY	Transcriptional Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- by Methyl_CpG Binding Protein 2 -LRB- MeCP2 -RRB- : a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple_Sclerosis -LRB- MS -RRB- .
17046689	0	MeCP2	34,39	Bdnf	69,73	MeCP2	Bdnf	4204	627	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|transcription transcription|compound|END_ENTITY	Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription , dendritic growth , and spine maturation .
25579386	0	MeCP2	104,109	Brain-Derived_Neurotrophic_Factor	30,63	MeCP2	Brain-Derived Neurotrophic Factor	4204	627	Gene	Gene	Protein|appos|START_ENTITY END_ENTITY|nmod|Protein	Transcriptional Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- by Methyl_CpG Binding Protein 2 -LRB- MeCP2 -RRB- : a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple_Sclerosis -LRB- MS -RRB- .
20211261	0	MeCP2	17,22	CDKL5	0,5	MeCP2	CDKL5	29386(Tax:10116)	100362725	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	CDKL5 is a brain MeCP2 target gene regulated by DNA methylation .
26511729	0	MeCP2	0,5	DUSP5	88,93	MeCP2	DUSP5	4204	1847	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5 .
24990928	0	MeCP2	0,5	G9a	20,23	MeCP2	G9a	17257(Tax:10090)	110147(Tax:10090)	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	MeCP2 repression of G9a in regulation of pain and morphine reward .
24269336	0	MeCP2	0,5	GFAP	16,20	MeCP2	GFAP	29386(Tax:10116)	24387(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MeCP2 regulates GFAP expression within the developing brain .
25716866	0	MeCP2	94,99	Glua1	114,119	MeCP2	Glua1	29386(Tax:10116)	50592(Tax:10116)	Gene	Gene	Repression|amod|START_ENTITY Repression|nmod|END_ENTITY	Persistent Pain Maintains Morphine-Seeking Behavior after Morphine Withdrawal through Reduced MeCP2 Repression of Glua1 in Rat Central Amygdala .
17698499	0	MeCP2	0,5	HP1	21,24	MeCP2	HP1	4204	23468	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MeCP2 interacts with HP1 and modulates its heterochromatin association during myogenic differentiation .
22275515	0	MeCP2	79,84	LEDGF/p75	23,32	MeCP2	LEDGF/p75	4204	11168	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The stress oncoprotein LEDGF/p75 interacts with the methyl_CpG binding protein MeCP2 and influences its transcriptional activity .
26189965	0	MeCP2	53,58	Melittin	0,8	MeCP2	Melittin	4204	406130(Tax:7460)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular_carcinoma SMMC-7721 cells .
26189965	0	MeCP2	53,58	PTCH1	17,22	MeCP2	PTCH1	4204	5727	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular_carcinoma SMMC-7721 cells .
23759142	0	MeCP2	110,115	TAC1	100,104	MeCP2	TAC1	4204	6863	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Comparative DNA methylation among females with neurodevelopmental_disorders and seizures identifies TAC1 as a MeCP2 target gene .
23200852	0	MeCP2	0,5	Wnt	30,33	MeCP2	Wnt	29386(Tax:10116)	114487(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activation activation|compound|END_ENTITY	MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid_arthritis fibroblast-like synoviocytes in rats .
26344767	0	MeCP2	15,20	mTOR	26,30	MeCP2	mTOR	17257(Tax:10090)	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes .
22207122	0	MeCP2	102,107	methyl-CpG-binding_protein_2	72,100	MeCP2	methyl-CpG-binding protein 2	4204	4204	Gene	Gene	expressions|appos|START_ENTITY expressions|amod|END_ENTITY	Early intervention with psychostimulants or antidepressants to increase methyl-CpG-binding_protein_2 -LRB- MeCP2 -RRB- expressions : a potential therapy for Rett_syndrome .
22822052	0	MeCP2	65,70	methyl-CpG-binding_protein_2	35,63	MeCP2	methyl-CpG-binding protein 2	4204	4204	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Nuclear calcium signaling controls methyl-CpG-binding_protein_2 -LRB- MeCP2 -RRB- phosphorylation on serine 421 following synaptic activity .
24586187	0	Mec1	14,18	Ddc2	0,4	Mec1	Ddc2	852433(Tax:4932)	852110(Tax:4932)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Ddc2 mediates Mec1 activation through a Ddc1 - or Dpb11-independent mechanism .
19457865	0	Mec1	38,42	Mrc1	67,71	Mec1	Mrc1	852433(Tax:4932)	850297(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1 .
11154263	0	Mec1	33,37	Pie1	0,4	Mec1	Pie1	852433(Tax:4932)	852110(Tax:4932)	Gene	Gene	interacting|nmod|START_ENTITY protein|acl|interacting END_ENTITY|appos|protein	Pie1 , a protein interacting with Mec1 , controls cell growth and checkpoint responses in Saccharomyces_cerevisiae .
16365046	0	Mec1	90,94	Rad53	36,41	Mec1	Rad53	545	11200	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Activation of the checkpoint kinase Rad53 by the phosphatidyl_inositol kinase-like kinase Mec1 .
15121837	0	Mec1	71,75	Sae2	31,35	Mec1	Sae2	852433(Tax:4932)	852700(Tax:4932)	Gene	Gene	phosphorylation|amod|START_ENTITY require|dobj|phosphorylation require|nsubj|functions functions|nmod|END_ENTITY	The functions of budding yeast Sae2 in the DNA damage response require Mec1 - and Tel1-dependent phosphorylation .
16861895	0	Mec1	47,51	Sae2	14,18	Mec1	Sae2	852433(Tax:4932)	852700(Tax:4932)	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis .
14988729	0	Mec1p	23,28	Esc4p	0,5	Mec1p	Esc4p	852433(Tax:4932)	856559(Tax:4932)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Esc4p , a new target of Mec1p -LRB- ATR -RRB- , promotes resumption of DNA synthesis after DNA damage .
11983176	0	Mec1p	15,20	Lcd1p	0,5	Mec1p	Lcd1p	545	7045	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo .
11433293	0	Mec1p	0,5	Pds1p	16,21	Mec1p	Pds1p	545	7986	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Mec1p regulates Pds1p levels in S phase : complex coordination of DNA replication and mitosis .
16446138	0	Mecp2	27,32	BDNF	73,77	Mecp2	BDNF	17257(Tax:10090)	12064(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY progression|nmod|mice affected|nsubjpass|progression affected|nmod|level level|nmod|expression expression|compound|END_ENTITY	The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression .
23027959	0	Mecp2	89,94	BDNF	19,23	Mecp2	BDNF	17257(Tax:10090)	12064(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY neurons|nmod|mice impaired|nmod|neurons impaired|nsubjpass|release release|amod|END_ENTITY	Activity-dependent BDNF release and TRPC signaling is impaired in hippocampal neurons of Mecp2 mutant mice .
24639629	0	Mecp2	98,103	BDNF	53,57	Mecp2	BDNF	17257(Tax:10090)	12064(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY neurons|nmod|mice improves|nmod|neurons improves|dobj|trafficking trafficking|amod|END_ENTITY	A selective histone_deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice : implications for Rett_syndrome .
25634725	0	Mecp2	117,122	BDNF	77,81	Mecp2	BDNF	17257(Tax:10090)	12064(Tax:10090)	Gene	Gene	Isoforms|nmod|START_ENTITY Isoforms|nsubj|Expression Expression|nmod|mRNA mRNA|appos|END_ENTITY	Differential Expression and Regulation of Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- mRNA Isoforms in Brain Cells from Mecp2 -LRB- 308/y -RRB- Mouse Model .
25209930	0	Mecp2	92,97	CA3	85,88	Mecp2	CA3	17257(Tax:10090)	12350(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice .
27080430	0	Mecp2	52,57	Methyl-CpG_binding_protein_2	22,50	Mecp2	Methyl-CpG binding protein 2	17257(Tax:10090)	17257(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of nuclear Methyl-CpG_binding_protein_2 -LRB- Mecp2 -RRB- is dependent on neuronal stimulation and application of Insulin-like_growth_factor_1 .
26185009	0	Mecp2	72,77	N-Methyl-D-Aspartate_Receptor	28,57	Mecp2	N-Methyl-D-Aspartate Receptor	17257(Tax:10090)	14810(Tax:10090)	Gene	Gene	Maturation|nmod|START_ENTITY Maturation|compound|END_ENTITY	Cell-Specific Regulation of N-Methyl-D-Aspartate_Receptor Maturation by Mecp2 in Cortical Circuits .
26553192	0	Med14	0,5	brg1	22,26	Med14	brg1	336923(Tax:7955)	353295(Tax:7955)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest .
24960263	0	Med25	0,5	estrogen_receptor_alpha	22,45	Med25	estrogen receptor alpha	81857	2099	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Med25 is required for estrogen_receptor_alpha -LRB- ERa -RRB- - mediated regulation of human CYP2C9 expression .
12054864	0	Med8p	16,21	hexokinase_2	41,53	Med8p	hexokinase 2	852492(Tax:4932)	852639(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mediator factor Med8p interacts with the hexokinase_2 : implication in the glucose signalling pathway of Saccharomyces_cerevisiae .
20521098	0	Mediator_of_DNA_damage_checkpoint_protein_1	0,43	MDC1	45,49	Mediator of DNA damage checkpoint protein 1	MDC1	9656	9656	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mediator_of_DNA_damage_checkpoint_protein_1 -LRB- MDC1 -RRB- expression as a prognostic marker for nodal recurrence in early-stage_breast_cancer patients treated with breast-conserving surgery and radiation therapy .
22532615	0	Mediterranean_FeVer	9,28	MEFV	35,39	Mediterranean FeVer	MEFV	4210	4210	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Familial Mediterranean_FeVer gene -LRB- MEFV -RRB- mutations as a modifier of systemic_lupus_erythematosus .
17520284	0	Mediterranean_fever	13,32	MEFV	34,38	Mediterranean fever	MEFV	4210	4210	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The familial Mediterranean_fever -LRB- MEFV -RRB- gene may be a modifier factor of inflammatory_bowel_disease in infancy .
23297013	0	Mediterranean_fever	37,56	MEFV	58,62	Mediterranean fever	MEFV	4210	4210	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of missense mutations of Mediterranean_fever -LRB- MEFV -RRB- gene with multiple_sclerosis in Turkish population .
23889933	0	Mef2	25,29	Fas2	65,69	Mef2	Fas2	36032(Tax:7227)	31364(Tax:7227)	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	The transcription factor Mef2 links the Drosophila core clock to Fas2 , neuronal morphology , and circadian behavior .
22899845	0	Mef2	18,22	miR-92b	0,7	Mef2	miR-92b	36032(Tax:7227)	12798263	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development .
20923879	0	Mef2	41,45	myocyte_enhancer_factor-2	14,39	Mef2	myocyte enhancer factor-2	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Heterogeneous myocyte_enhancer_factor-2 -LRB- Mef2 -RRB- activation in myocytes predicts focal scarring in hypertrophic_cardiomyopathy .
25108515	0	Mef2C	98,103	myocyte_enhancer_factor_2C	70,96	Mef2C	myocyte enhancer factor 2C	512254(Tax:9913)	512254(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Postnatal expression patterns and polymorphism analysis of the bovine myocyte_enhancer_factor_2C -LRB- Mef2C -RRB- gene .
26923194	0	Mef2c	79,84	Aquaporin-1	12,23	Mef2c	Aquaporin-1	4208	358	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|Expression Expression|compound|END_ENTITY	Endothelial Aquaporin-1 -LRB- AQP1 -RRB- Expression Is Regulated by Transcription Factor Mef2c .
23789100	0	Mef2c	17,22	Cited3	0,6	Mef2c	Cited3	17260(Tax:10090)	100006037(Tax:7955)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Cited3 activates Mef2c to control muscle cell differentiation and survival .
19914232	0	Mef2c	34,39	Foxj3	0,5	Mef2c	Foxj3	17260(Tax:10090)	230700(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Foxj3 transcriptionally activates Mef2c and regulates adult skeletal muscle fiber type identity .
21715356	0	Mef2c	47,52	Rpe65	84,89	Mef2c	Rpe65	17260(Tax:10090)	19892(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Altered expression of the transcription factor Mef2c during retinal_degeneration in Rpe65 - / - mice .
22367967	0	Mef2c	32,37	Tbx1	0,4	Mef2c	Tbx1	17260(Tax:10090)	21380(Tax:10090)	Gene	Gene	modulator|nmod|START_ENTITY modulator|nsubj|END_ENTITY	Tbx1 is a negative modulator of Mef2c .
26482610	0	Meg3	57,61	Skp2	0,4	Meg3	Skp2	55384	6502	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Skp2 regulates non-small_cell_lung_cancer cell growth by Meg3 and miR-3163 .
12508107	0	MegBP	67,72	megalin	26,33	MegBP	megalin	55805	4036	Gene	Gene	interaction|dep|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of megalin with the megalinbinding protein -LRB- MegBP -RRB- , a novel tetratrico peptide repeat-containing adaptor molecule .
20637285	0	Megalin	0,7	APP	23,26	Megalin	APP	4036	351	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Megalin interacts with APP and the intracellular adapter protein FE65 in neurons .
19340093	0	Megalin	0,7	Disabled-2	79,89	Megalin	Disabled-2	29216(Tax:10116)	79128(Tax:10116)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Megalin and nonmuscle_myosin_heavy_chain_IIA interact with the adaptor protein Disabled-2 in proximal tubule cells .
15467006	0	Megalin	0,7	angiotensin_II	31,45	Megalin	angiotensin II	4036	183	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Megalin binds and internalizes angiotensin_II .
16099815	0	Megalin	0,7	apolipoprotein_M	26,42	Megalin	apolipoprotein M	29216(Tax:10116)	55939(Tax:10116)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Megalin is a receptor for apolipoprotein_M , and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein_M .
15962301	0	Megator	20,27	EAST	0,4	Megator	EAST	36264(Tax:7227)	46006(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	EAST interacts with Megator and localizes to the putative spindle matrix during mitosis in Drosophila .
23526974	0	Mei-p26	0,7	Bam	24,27	Mei-p26	Bam	45775(Tax:7227)	43038(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Mei-p26 cooperates with Bam , Bgcn and Sxl to promote early germline development in the Drosophila ovary .
15755900	0	Meis1	0,5	FLT3	32,36	Meis1	FLT3	4211	2322	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Meis1 programs transcription of FLT3 and cancer stem cell character , using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus .
24244849	0	Meis1	0,5	Foxn4	16,21	Meis1	Foxn4	4211	121643	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Meis1 regulates Foxn4 expression during retinal progenitor cell differentiation .
19620287	0	Meis1	38,43	HOXA9	0,5	Meis1	HOXA9	17268(Tax:10090)	15405(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis .
22829978	0	Meis1	55,60	c-myb	23,28	Meis1	c-myb	17268(Tax:10090)	17863(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Distinct regulation of c-myb gene expression by HoxA9 , Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells .
11262231	0	Meis3	0,5	Pbx4	22,26	Meis3	Pbx4	81885(Tax:7955)	30728(Tax:7955)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish .
26981366	0	Mek	82,85	Erk	39,42	Mek	Erk	17242(Tax:10090)	26413(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	RNA sequencing analysis to demonstrate Erk dependent and independent functions of Mek .
7876076	0	Mek-4	132,137	ELF-1	117,122	Mek-4	ELF-1	13837(Tax:10090)	13709(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|appos|END_ENTITY	cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand -LRB- ELF-1 -RRB- for the Mek-4 and Sek receptor protein-tyrosine kinases .
21674483	0	Mel-18	24,30	Il17a	38,43	Mel-18	Il17a	7703	3605	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines .
18706886	0	Mel-18	0,6	RanGAP1	22,29	Mel-18	RanGAP1	7703	5905	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mel-18 interacts with RanGAP1 and inhibits its sumoylation .
16182291	0	Mel-18	32,38	cyclin_D2	54,63	Mel-18	cyclin D2	7703	894	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The polycomb group gene product Mel-18 interacts with cyclin_D2 and modulates its activity .
19727227	0	Mel18	75,80	emerin	100,106	Mel18	emerin	7703	2010	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Association of progerin-interactive partner proteins with lamina proteins : Mel18 is associated with emerin in HGPS .
11316328	0	Mel1c	71,76	mt1	115,118	Mel1c	mt1	9248	644314	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Chimeric Galphaq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors .
9850054	0	Melan-A	108,115	CD8	14,17	Melan-A	CD8	2315	925	Gene	Gene	gene|compound|START_ENTITY express|dobj|gene engineered|xcomp|express cells|amod|engineered +|nmod|cells +|nsubj|Generation Generation|nmod|+ +|compound|END_ENTITY	Generation of CD8 + and CD4 + T-cell response to dendritic cells genetically engineered to express the MART-1 / Melan-A gene .
9850054	0	Melan-A	108,115	MART-1	101,107	Melan-A	MART-1	2315	2315	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Generation of CD8 + and CD4 + T-cell response to dendritic cells genetically engineered to express the MART-1 / Melan-A gene .
15950311	0	Melanin-concentrating_hormone_receptor_1	73,113	MIZIP	36,41	Melanin-concentrating hormone receptor 1	MIZIP	2847	116225	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Immunohistochemical distribution of MIZIP and its co-expression with the Melanin-concentrating_hormone_receptor_1 in the adult rodent brain .
25898270	0	Melanocortin-4_Receptor	154,177	Agouti-Related_Protein	86,108	Melanocortin-4 Receptor	Agouti-Related Protein	17202(Tax:10090)	11604(Tax:10090)	Gene	Gene	AGRP|nmod|START_ENTITY AGRP|nsubj|Discovery Discovery|nmod|Mimetic Mimetic|nmod|-LSB- -LSB-|compound|END_ENTITY	Discovery of a b-Hairpin Octapeptide , c -LSB- Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro -RSB- , Mimetic of Agouti-Related_Protein -LRB- 87-132 -RRB- -LSB- AGRP -LRB- 87-132 -RRB- -RSB- with Equipotent Mouse Melanocortin-4_Receptor -LRB- mMC4R -RRB- Antagonist Pharmacology .
22493442	0	Melanocortin_1_receptor	0,23	syndecan-2	73,83	Melanocortin 1 receptor	syndecan-2	17199(Tax:10090)	15529(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Melanocortin_1_receptor regulates melanoma cell migration by controlling syndecan-2 expression .
26788538	0	Melanocortin_4_receptor	24,47	MC4R	49,53	Melanocortin 4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic variants of the Melanocortin_4_receptor -LRB- MC4R -RRB- gene in a South African study group .
21664420	0	Melanocortin_4_receptor	0,23	nescient_helix-loop-helix-2	55,82	Melanocortin 4 receptor	nescient helix-loop-helix-2	4160	4808	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Melanocortin_4_receptor is a transcriptional target of nescient_helix-loop-helix-2 .
19428994	0	Melanocortin_5_receptor	0,23	ERK1/2	34,40	Melanocortin 5 receptor	ERK1/2	4161	5595;5594	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Melanocortin_5_receptor activates ERK1/2 through a PI3K-regulated signaling mechanism .
21574154	0	Melanoma-associated_antigen	0,27	MAGE	29,33	Melanoma-associated antigen	MAGE	57730	57730	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Melanoma-associated_antigen -LRB- MAGE -RRB- expression in the normal mucosa around colorectal_cancer after curative resection : presence of undetectable free cancer cells .
11934156	0	Melanoma_Cell_Adhesion_Molecule	0,31	MCAM	33,37	Melanoma Cell Adhesion Molecule	MCAM	448832(Tax:9031)	448832(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Melanoma_Cell_Adhesion_Molecule -LRB- MCAM -RRB- expression in the myogenic lineage during early chick embryonic development .
19147576	0	Melanoma_antigen-11	0,19	hypoxia-inducible_factor_prolyl_hydroxylase_2	33,78	Melanoma antigen-11	hypoxia-inducible factor prolyl hydroxylase 2	4110	54583	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|response response|amod|END_ENTITY	Melanoma_antigen-11 inhibits the hypoxia-inducible_factor_prolyl_hydroxylase_2 and activates hypoxic response .
26330556	0	Melanoma_antigen-A11	38,58	MAGE-A11	60,68	Melanoma antigen-A11	MAGE-A11	4110	4110	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Post-translational Down-regulation of Melanoma_antigen-A11 -LRB- MAGE-A11 -RRB- by Human p14-ARF_Tumor_Suppressor .
12771231	0	Melanoma_cell_adhesion_molecule	0,31	hCG	129,132	Melanoma cell adhesion molecule	hCG	4162	1081	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Melanoma_cell_adhesion_molecule -LRB- MCAM/CD146 -RRB- is expressed on human luteinizing granulosa cells : enhancement of its expression by hCG , interleukin-1_and_tumour_necrosis_factor-alpha .
22892369	0	Melanoma_differentiation-associated_gene_5	0,42	CXCL10	83,89	Melanoma differentiation-associated gene 5	CXCL10	64135	3627	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Melanoma_differentiation-associated_gene_5 regulates the expression of a chemokine CXCL10 in human mesangial cells : implications for chronic inflammatory_renal_diseases .
11980908	1	Melanophilin	36,48	Rab27a	55,61	Melanophilin	Rab27a	79083	5873	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Melanophilin links Rab27a and myosin_Va function in melanosome transport .
12062444	0	Melanophilin	0,12	Rab27a	28,34	Melanophilin	Rab27a	79083	5873	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Melanophilin directly links Rab27a and myosin_Va through its distinct coiled-coil regions .
22809454	0	Melatonin_Receptor_1A	24,45	MTNR1A	47,53	Melatonin Receptor 1A	MTNR1A	443022(Tax:9940)	443022(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterisation of the Melatonin_Receptor_1A -LRB- MTNR1A -RRB- gene in the Rasa Aragonesa sheep breed : association with reproductive seasonality .
26431121	0	Melatonin_Receptor_1B	49,70	MTNR1B	72,78	Melatonin Receptor 1B	MTNR1B	4544	4544	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	The Association of rs4753426 Polymorphism in the Melatonin_Receptor_1B -LRB- MTNR1B -RRB- Gene and Susceptibility to Adolescent_Idiopathic_Scoliosis : A Systematic Review and Meta-analysis .
17632395	0	Melatonin_receptor_1B	0,21	MTNR1B	23,29	Melatonin receptor 1B	MTNR1B	4544	4544	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Melatonin_receptor_1B -LRB- MTNR1B -RRB- gene polymorphism is associated with the occurrence of adolescent_idiopathic_scoliosis .
25053591	0	Melittin	0,8	HIF-1a	99,105	Melittin	HIF-1a	406130(Tax:7460)	3091	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Melittin enhances radiosensitivity of hypoxic head_and_neck_squamous_cell_carcinoma by suppressing HIF-1a .
26189965	0	Melittin	0,8	MeCP2	53,58	Melittin	MeCP2	406130(Tax:7460)	4204	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular_carcinoma SMMC-7721 cells .
26189965	0	Melittin	0,8	PTCH1	17,22	Melittin	PTCH1	406130(Tax:7460)	5727	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular_carcinoma SMMC-7721 cells .
16144839	0	Melk	69,73	Cnap1	44,49	Melk	Cnap1	17279(Tax:10090)	68298(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the condensin component Cnap1 and protein kinase Melk as novel E2F target genes down-regulated by 1,25-dihydroxyvitamin _ D3 .
10417823	0	Melk	14,18	protein_kinase	26,40	Melk	protein kinase	17279(Tax:10090)	53859(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Melk , a new protein_kinase , during early mouse development .
11769731	0	Meltrin-alpha	23,36	ADAM12	15,21	Meltrin-alpha	ADAM12	8038	8038	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Expression of ADAM12 -LRB- Meltrin-alpha -RRB- gene in giant_cell_tumor_of_bone -RSB- .
10753657	0	Meltrin_beta	0,12	ADAM19	14,20	Meltrin beta	ADAM19	303068(Tax:10116)	11492(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Meltrin_beta -LRB- ADAM19 -RRB- gene : cloning , mapping , and analysis of the regulatory region .
20017903	0	Melusin	0,7	ITGB1BP2	14,22	Melusin	ITGB1BP2	26548	26548	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Melusin gene -LRB- ITGB1BP2 -RRB- nucleotide variations study in hypertensive and cardiopathic patients .
18393797	0	Memapsin_2	0,10	beta-secretase	12,26	Memapsin 2	beta-secretase	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Memapsin_2 -LRB- beta-secretase -RRB- inhibitors : drug development .
26208648	0	Memb11	13,19	Arf1	48,52	Memb11	Arf1	818264(Tax:3702)	842268(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Qb-SNARE Memb11 interacts specifically with Arf1 in the Golgi apparatus of Arabidopsis_thaliana .
26208648	0	Memb11	13,19	Arf1	48,52	Memb11	Arf1	818264(Tax:3702)	842268(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Qb-SNARE Memb11 interacts specifically with Arf1 in the Golgi apparatus of Arabidopsis_thaliana .
26204513	0	Membrane-Type_1_Matrix_Metalloproteinase	80,120	MT1-MMP	122,129	Membrane-Type 1 Matrix Metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	The Oncogenic Response to MiR-335 Is Associated with Cell Surface Expression of Membrane-Type_1_Matrix_Metalloproteinase -LRB- MT1-MMP -RRB- Activity .
26204513	0	Membrane-Type_1_Matrix_Metalloproteinase	80,120	MT1-MMP	122,129	Membrane-Type 1 Matrix Metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	The Oncogenic Response to MiR-335 Is Associated with Cell Surface Expression of Membrane-Type_1_Matrix_Metalloproteinase -LRB- MT1-MMP -RRB- Activity .
21937444	0	Membrane-associated_RING-CH_10	0,30	MARCH10	32,39	Membrane-associated RING-CH 10	MARCH10	303596(Tax:10116)	303596(Tax:10116)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Membrane-associated_RING-CH_10 -LRB- MARCH10 protein -RRB- is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella .
11381077	0	Membrane-type_1_matrix_metalloproteinase	0,40	CD44	49,53	Membrane-type 1 matrix metalloproteinase	CD44	4323	960	Gene	Gene	cleaves|amod|START_ENTITY END_ENTITY|nsubj|cleaves	Membrane-type_1_matrix_metalloproteinase cleaves CD44 and promotes cell migration .
7708715	0	Membrane-type_matrix_metalloproteinase	0,38	MT-MMP	40,46	Membrane-type matrix metalloproteinase	MT-MMP	4323	4323	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Membrane-type_matrix_metalloproteinase -LRB- MT-MMP -RRB- gene is expressed in stromal cells of human colon , _ breast , _ and_head_and_neck_carcinomas .
15516694	0	Membrane_type_1-matrix_metalloproteinase	0,40	CXCL8	126,131	Membrane type 1-matrix metalloproteinase	CXCL8	4323	3576	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Membrane_type_1-matrix_metalloproteinase is regulated by chemokines monocyte-chemoattractant_protein-1 / ccl2 and interleukin-8 / CXCL8 in endothelial cells during angiogenesis .
10936671	0	Membrane_type_1-matrix_metalloproteinase	0,40	E-cadherin	68,78	Membrane type 1-matrix metalloproteinase	E-cadherin	4323	999	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Membrane_type_1-matrix_metalloproteinase expression is regulated by E-cadherin through the suppression of mitogen-activated protein kinase cascade .
22315223	0	Membrane_type_1_matrix_metalloproteinase	0,40	MT1-MMP	42,49	Membrane type 1 matrix metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	ubiquitination|amod|START_ENTITY ubiquitination|appos|END_ENTITY	Membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- ubiquitination at Lys581 increases cellular invasion through type I collagen .
8939968	0	Membrane_type_matrix_metalloproteinase_1	0,40	pro-gelatinase_A	51,67	Membrane type matrix metalloproteinase 1	pro-gelatinase A	4323	4313	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Membrane_type_matrix_metalloproteinase_1 activates pro-gelatinase_A without furin cleavage of the N-terminal domain .
17145768	0	Men1	45,49	p18Ink4c	0,8	Men1	p18Ink4c	17283(Tax:10090)	12580(Tax:10090)	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	p18Ink4c , but not p27Kip1 , collaborates with Men1 to suppress neuroendocrine_organ_tumors .
23832697	0	Mena	45,49	Mammalian_enabled	26,43	Mena	Mammalian enabled	55740	55740	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Cardiac overexpression of Mammalian_enabled -LRB- Mena -RRB- exacerbates heart_failure in mice .
24186093	0	Mena	0,4	Rac1	21,25	Mena	Rac1	13800(Tax:10090)	19353(Tax:10090)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Mena associates with Rac1 and modulates connexin_43 remodeling in cardiomyocytes .
25031323	0	Mena	80,84	mammalian_enabled	61,78	Mena	mammalian enabled	55740	55740	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Dynamin1 is a novel target for IRSp53 protein and works with mammalian_enabled -LRB- Mena -RRB- protein and Eps8 to regulate filopodial dynamics .
23394438	0	Meningioma_1	0,12	MN1	14,17	Meningioma 1	MN1	4330	4330	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Meningioma_1 -LRB- MN1 -RRB- expression : refined risk stratification in acute_myeloid_leukemia with normal cytogenetics -LRB- CN-AML -RRB- .
19383287	0	Meox2	19,24	TGF-beta	70,78	Meox2	TGF-beta	4223	7040	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of Meox2 during the epithelial cytostatic response to TGF-beta .
4077150	0	Mep-1	17,22	H-2D	31,35	Mep-1	H-2D	17287(Tax:10090)	83772(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Proximity of the Mep-1 gene to H-2D on chromosome 17 in mice .
10806353	0	Mep1b	57,62	meprin_beta	39,50	Mep1b	meprin beta	17288(Tax:10090)	17288(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the mouse metalloprotease meprin_beta gene -LRB- Mep1b -RRB- : alternative splicing in cancer cells .
17493133	0	Mep2	37,41	Npr1	74,78	Mep2	Npr1	855580(Tax:4932)	855538(Tax:4932)	Gene	Gene	START_ENTITY|appos|kinase kinase|amod|END_ENTITY	The yeast ammonium transport protein Mep2 and its positive regulator , the Npr1 kinase , play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium .
22179835	0	Mer	0,3	receptor_tyrosine_kinase	4,28	Mer	receptor tyrosine kinase	10461	5979	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Mer receptor_tyrosine_kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology .
17286053	0	Mer3	35,39	HFM1	0,4	Mer3	HFM1	852641(Tax:4932)	164045	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	HFM1 , the human homologue of yeast Mer3 , encodes a putative DNA helicase expressed specifically in germ-line cells .
14704368	0	MerTK	29,34	phospholipase_C_gamma2	45,67	MerTK	phospholipase C gamma2	17289(Tax:10090)	234779(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The receptor tyrosine kinase MerTK activates phospholipase_C_gamma2 during recognition of apoptotic thymocytes by murine macrophages .
9703963	0	Merlin	0,6	moesin	20,26	Merlin	moesin	18016(Tax:10090)	17698(Tax:10090)	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Merlin differs from moesin in binding to F-actin and in its intra - and intermolecular interactions .
10214350	0	Merlin	0,6	neurofibromatosis_2	12,31	Merlin	neurofibromatosis 2	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	START_ENTITY|dep|suppressor suppressor|amod|END_ENTITY	Merlin : the neurofibromatosis_2 tumor suppressor .
15123692	0	Merlin	0,6	transactivation-responsive_RNA-binding_protein	43,89	Merlin	transactivation-responsive RNA-binding protein	18016(Tax:10090)	21357(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Merlin , a tumor suppressor , interacts with transactivation-responsive_RNA-binding_protein and inhibits its oncogenic activity .
8830776	0	Merosin	0,7	merosin	60,67	Merosin	merosin	16773(Tax:10090)	16773(Tax:10090)	Gene	Gene	START_ENTITY|dep|requirement requirement|nmod|END_ENTITY	Merosin and laminin in myogenesis ; specific requirement for merosin in myotube stability and survival .
15143163	0	Mesd	70,74	LRP5	48,52	Mesd	LRP5	23184	4041	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd .
20446724	0	Mesd	0,4	LRP5	49,53	Mesd	LRP5	23184	4041	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells .
20573372	0	Mesothelin	0,10	MSLN	12,16	Mesothelin	MSLN	10232	10232	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Mesothelin -LRB- MSLN -RRB- promoter is hypomethylated in malignant_mesothelioma , but its expression is not associated with methylation status of the promoter .
22402664	0	Mesp1	21,26	Eomesodermin	0,12	Mesp1	Eomesodermin	55897	8320	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin .
25641698	0	Mesp2	79,84	Tbx6	48,52	Mesp2	Tbx6	17293(Tax:10090)	21389(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|compound|END_ENTITY	Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2 .
7713495	0	Met-ase	10,17	GZMM	24,28	Met-ase	GZMM	3004	3004	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human Met-ase gene -LRB- GZMM -RRB- : structure , sequence , and close physical linkage to the serine protease gene cluster on 19p13 .3 .
2087436	0	Met-enkephalin	19,33	Met-enkephalin	57,71	Met-enkephalin	Met-enkephalin	5443	5443	Gene	Gene	forms|amod|START_ENTITY forms|nmod|END_ENTITY	Release in vivo of Met-enkephalin and encrypted forms of Met-enkephalin from brain and spinal cord of the anesthetized cat .
2087436	0	Met-enkephalin	57,71	Met-enkephalin	19,33	Met-enkephalin	Met-enkephalin	5443	5443	Gene	Gene	forms|nmod|START_ENTITY forms|amod|END_ENTITY	Release in vivo of Met-enkephalin and encrypted forms of Met-enkephalin from brain and spinal cord of the anesthetized cat .
1592064	0	Met-enkephalin	0,14	beta-endorphin	16,30	Met-enkephalin	beta-endorphin	5443	5443	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	Met-enkephalin , beta-endorphin and cortisol responses to sub-maximal exercise after sleep_disturbances .
9622017	0	Met1	45,49	bradykinin	57,67	Met1	bradykinin	3004	3827	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Purification and cardiovascular activity of -LSB- Met1 , Met5 -RSB- - bradykinin from the plasma of a sturgeon -LRB- Acipenseriformes -RRB- .
25950605	0	Metabolic_Syndrome	10,28	Mitsugumin_53	32,45	Metabolic Syndrome	Mitsugumin 53	100036290(Tax:10090)	493829	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	Effect of Metabolic_Syndrome on Mitsugumin_53 Expression and Function .
25674742	0	Metadherin	0,10	Vascular_Endothelial_Growth_Factor	25,59	Metadherin	Vascular Endothelial Growth Factor	92140	7422	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|Expression Expression|compound|END_ENTITY	Metadherin Regulation of Vascular_Endothelial_Growth_Factor Expression Is Dependent Upon the PI3K/Akt Pathway in Squamous_Cell_Carcinoma of the Head_and_Neck .
23803695	0	Metallopanstimulin-1	0,20	integrin_b4	96,107	Metallopanstimulin-1	integrin b4	6232	3691	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Metallopanstimulin-1 regulates invasion and migration of gastric_cancer cells partially through integrin_b4 .
1976815	0	Metallothionein	0,15	Mto	16,19	Metallothionein	Mto	42424(Tax:7227)	42424(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Metallothionein Mto gene of Drosophila_melanogaster : structure and regulation .
21187089	0	Metallothionein-2A	0,18	matrix_metalloproteinase-9	62,88	Metallothionein-2A	matrix metalloproteinase-9	4502	4318	Gene	Gene	overexpression|amod|START_ENTITY increases|nsubj|overexpression increases|dobj|expression expression|nmod|END_ENTITY	Metallothionein-2A overexpression increases the expression of matrix_metalloproteinase-9 and invasion of breast_cancer cells .
18295594	0	Metallothionein-III	0,19	VEGF	48,52	Metallothionein-III	VEGF	17751(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells .
16162438	0	Metallothionein_1	0,17	vascular_endothelial_zinc_finger_1	44,78	Metallothionein 1	vascular endothelial zinc finger 1	644314	7716	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Metallothionein_1 is a downstream target of vascular_endothelial_zinc_finger_1 -LRB- VEZF1 -RRB- in endothelial cells and participates in the regulation of angiogenesis .
15101091	0	Metastasis-associated_S100A4	0,28	Mts1	30,34	Metastasis-associated S100A4	Mts1	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Metastasis-associated_S100A4 -LRB- Mts1 -RRB- protein is expressed in subpopulations of sensory and autonomic neurons and in Schwann cells of the adult rat .
15254226	0	Metastasis-associated_protein_1	0,31	NRIF3	47,52	Metastasis-associated protein 1	NRIF3	9112	23421	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Metastasis-associated_protein_1 interacts with NRIF3 , an estrogen-inducible nuclear receptor coregulator .
16511565	0	Metastasis-associated_protein_1	0,31	histone_deacetylase_1	108,129	Metastasis-associated protein 1	histone deacetylase 1	9112	3065	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Metastasis-associated_protein_1 enhances stability of hypoxia-inducible_factor-1alpha protein by recruiting histone_deacetylase_1 .
16645043	0	Metastasis-associated_protein_2	0,31	estrogen_receptor_alpha	50,73	Metastasis-associated protein 2	estrogen receptor alpha	9219	2099	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Metastasis-associated_protein_2 is a repressor of estrogen_receptor_alpha whose overexpression leads to estrogen-independent growth of human breast_cancer cells .
25884643	0	Metastasis_Associated_in_Colon_Cancer_1	26,65	MACC1	67,72	Metastasis Associated in Colon Cancer 1	MACC1	346389	346389	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Heterogeneity analysis of Metastasis_Associated_in_Colon_Cancer_1 -LRB- MACC1 -RRB- for survival prognosis of colorectal_cancer patients : a retrospective cohort study .
10381257	0	Metaxin_1	0,9	metaxin_2	25,34	Metaxin 1	metaxin 2	4580	10651	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Metaxin_1 interacts with metaxin_2 , a novel related protein associated with the mammalian mitochondrial outer membrane .
24794530	0	Metaxins_1_and_2	0,16	TNF_alpha	132,141	Metaxins 1 and 2	TNF alpha	4580;10651	7124	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Metaxins_1_and_2 , two proteins of the mitochondrial protein sorting and assembly machinery , are essential for Bak activation during TNF_alpha triggered apoptosis .
24735585	0	Methionine_sulfoxide_reductase	0,30	catechol-O-methyl_transferase	47,76	Methionine sulfoxide reductase	catechol-O-methyl transferase	210009(Tax:10090)	12846(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Methionine_sulfoxide_reductase regulates brain catechol-O-methyl_transferase activity .
24399845	0	Methyl-CpG-binding_protein_2	0,28	MECP2	30,35	Methyl-CpG-binding protein 2	MECP2	4204	4204	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Methyl-CpG-binding_protein_2 -LRB- MECP2 -RRB- mutation type is associated with disease severity in Rett_syndrome .
24939308	0	Methyl-CpG_binding_domain_protein_2	10,45	MBD2	47,51	Methyl-CpG binding domain protein 2	MBD2	17191(Tax:10090)	17191(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of Methyl-CpG_binding_domain_protein_2 -LRB- MBD2 -RRB- on AMD-like lesions in ApoE-deficient mice .
27080430	0	Methyl-CpG_binding_protein_2	22,50	Mecp2	52,57	Methyl-CpG binding protein 2	Mecp2	17257(Tax:10090)	17257(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of nuclear Methyl-CpG_binding_protein_2 -LRB- Mecp2 -RRB- is dependent on neuronal stimulation and application of Insulin-like_growth_factor_1 .
26687138	0	Methylenetetrahydrafolate_Reductase_Gene_Polymorphism	15,68	MTHFR	70,75	Methylenetetrahydrafolate Reductase Gene Polymorphism	MTHFR	4524	4524	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of Methylenetetrahydrafolate_Reductase_Gene_Polymorphism -LRB- MTHFR -RRB- in Patients with Gallbladder_Cancer .
22952513	0	Methylenetetrahydrofolate_Reductase	6,41	MTHFR	43,48	Methylenetetrahydrofolate Reductase	MTHFR	4524	4524	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|compound|END_ENTITY	C677T Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- Gene Polymorphism in Schizophrenia and Bipolar_Disorder : An Association Study in Iranian Population .
23725631	0	Methylenetetrahydrofolate_Reductase	17,52	MTHFR	54,59	Methylenetetrahydrofolate Reductase	MTHFR	4524	4524	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Determination of Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- gene polymorphism in Turkish patients with nonsyndromic_cleft_lip_and_palate .
25745606	0	Methylenetetrahydrofolate_Reductase	24,59	MTHFR	61,66	Methylenetetrahydrofolate Reductase	MTHFR	4524	4524	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Common Mutations of the Methylenetetrahydrofolate_Reductase -LRB- MTHFR -RRB- Gene in Non-Syndromic Cleft Lips and Palates Children in North-West of Iran .
10928104	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism increases the risk of cervical_intraepithelial_neoplasia .
15300362	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism is associated with osteoporotic_vertebral_fractures , but is a weak predictor of BMD .
15385937	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene 677C > T and 1298A > C polymorphisms are associated with differential apoptosis of leukemic B cells in vitro and disease progression in chronic_lymphocytic_leukemia .
15551285	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	42,47	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- polymorphisms and reduced risk of malignant_lymphoma .
15916056	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism -LRB- C677T -RRB- in relation to homocysteine concentration in overweight and obese Thais .
18715139	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism is associated with spinal BMD in 9-year-old children .
20078613	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphisms and FOLFOX response in colorectal_cancer patients .
21489764	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene C677T , A1298C and G1793A polymorphisms : association with risk for clear_cell_renal_cell_carcinoma and tumour behaviour in men .
23395424	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene C677T polymorphism and risk of preeclampsia : an updated meta-analysis based on 51 studies .
24140489	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphisms and susceptibility to ischemic_stroke : a meta-analysis .
24229535	0	Methylenetetrahydrofolate_reductase	0,35	MTHFR	37,42	Methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- 677C/T polymorphism is associated with antipsychotic-induced weight_gain in first-episode schizophrenia .
26088413	0	Methylthioadenosine_Phosphorylase	14,47	MTAP	49,53	Methylthioadenosine Phosphorylase	MTAP	4507	4507	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Methylthioadenosine_Phosphorylase -LRB- MTAP -RRB- in Pilocytic_Astrocytomas .
14506228	0	Methylthioadenosine_phosphorylase	0,33	ornithine_decarboxylase	44,67	Methylthioadenosine phosphorylase	ornithine decarboxylase	4507	4953	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Methylthioadenosine_phosphorylase regulates ornithine_decarboxylase by production of downstream metabolites .
22231448	0	Metnase	24,31	Chk1	0,4	Metnase	Chk1	6419	1111	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart .
25024738	0	Metnase	25,32	Chk1	43,47	Metnase	Chk1	6419	1111	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	The DNA repair component Metnase regulates Chk1 stability .
24607956	0	Metnase	64,71	SETMAR	56,62	Metnase	SETMAR	6419	6419	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Delineation of known and new transcript variants of the SETMAR -LRB- Metnase -RRB- gene and the expression profile in hematologic_neoplasms .
22357625	0	Mex3c	0,5	insulin-like_growth_factor_1	16,44	Mex3c	insulin-like growth factor 1	240396(Tax:10090)	16000(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Mex3c regulates insulin-like_growth_factor_1 -LRB- IGF1 -RRB- expression and promotes postnatal growth .
23921378	0	Mff	58,61	MiD49	17,22	Mff	MiD49	56947	125170	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission .
24824927	0	Mfn1	21,25	MicroRNA-19b	0,12	Mfn1	MicroRNA-19b	55669	406980	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-19b targets Mfn1 to inhibit Mfn1-induced apoptosis in osteosarcoma cells .
22253285	0	Mfn2	31,35	Sp1	47,50	Mfn2	Sp1	9927	6667	Gene	Gene	activity|nmod|START_ENTITY depends|nsubj|activity depends|nmod|END_ENTITY	The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells .
162581	1	Mg2	68,71	ATPase	90,96	Mg2	ATPase	4589	1769	Gene	Gene	modification|nmod|START_ENTITY +|nsubj|modification +|dobj|activity activity|amod|END_ENTITY	Ca2 + modification of Mg2 + dependent dynein ATPase activity .
6148777	0	Mg2	59,62	ATPase	64,70	Mg2	ATPase	4589	1769	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Influence of myosin antiserum on heart sarcolemmal Ca2 + or Mg2 + ATPase activity .
21928827	0	Mg2	47,50	NCX1	36,40	Mg2	NCX1	4589	6546	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The second Ca -LRB- 2 + -RRB- - binding domain of NCX1 binds Mg2 + with high affinity .
12122020	0	Mgat5	58,63	N-acetylglucosaminyltransferase_V	23,56	Mgat5	N-acetylglucosaminyltransferase V	107895(Tax:10090)	107895(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Sequences of the mouse N-acetylglucosaminyltransferase_V -LRB- Mgat5 -RRB- mRNA and an mRNA expressed by an Mgat5-deficient cell line .
14744859	0	MgcRacGAP	55,64	Cdc42	81,86	MgcRacGAP	Cdc42	29127	998	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase .
17982282	0	MgcRacGAP	0,9	HIF-1alpha	25,35	MgcRacGAP	HIF-1alpha	29127	3091	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity .
14744859	0	MgcRacGAP	55,64	PRC1	41,45	MgcRacGAP	PRC1	29127	9055	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase .
14729465	0	MgcRacGAP	0,9	RhoA	46,50	MgcRacGAP	RhoA	29127	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MgcRacGAP regulates cortical activity through RhoA during cytokinesis .
25947135	0	MgcRacGAP	0,9	RhoA	27,31	MgcRacGAP	RhoA	431862(Tax:8355)	379416(Tax:8355)	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|END_ENTITY	MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells .
26252513	0	MgcRacGAP	29,38	RhoA	78,82	MgcRacGAP	RhoA	29127	387	Gene	Gene	functions|compound|START_ENTITY non-canonically|nsubj|functions non-canonically|advcl|promoting promoting|dobj|activation activation|compound|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
26252513	0	MgcRacGAP	29,38	RhoA	78,82	MgcRacGAP	RhoA	29127	387	Gene	Gene	functions|compound|START_ENTITY non-canonically|nsubj|functions non-canonically|advcl|promoting promoting|dobj|activation activation|compound|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
12590651	0	MgcRacGAP	55,64	Rnd2	18,22	MgcRacGAP	Rnd2	29127	8153	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells .
24807907	0	MgcRacGAP	0,9	cingulin	25,33	MgcRacGAP	cingulin	29127	57530	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly .
11601843	0	Mge1	89,93	Ssc1	46,50	Mge1	Ssc1	854407(Tax:4932)	853503(Tax:4932)	Gene	Gene	compete|nmod|START_ENTITY compete|nsubj|proteins proteins|appos|END_ENTITY	The two mitochondrial heat_shock proteins 70 , Ssc1 and Ssq1 , compete for the cochaperone Mge1 .
9048947	0	Mge1	0,4	Ssc1	50,54	Mge1	Ssc1	854407(Tax:4932)	853503(Tax:4932)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Mge1 functions as a nucleotide release factor for Ssc1 , a mitochondrial Hsp70 of Saccharomyces_cerevisiae .
21773674	0	Mgl1	20,24	Hoxc8	0,5	Mgl1	Hoxc8	16897(Tax:10090)	15426(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion .
21911365	0	Mgs1	30,34	PCNA	95,99	Mgs1	PCNA	855503(Tax:4932)	5111	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA .
1979024	0	Mgsa	65,69	Afp	79,82	Mgsa	Afp	14825(Tax:10090)	11576(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Localization of mouse melanoma growth stimulatory activity gene -LRB- Mgsa -RRB- between Afp and Gus on chromosome 5 using interspecific backcross mice .
12077345	0	Mi-2	11,15	dDREF	37,42	Mi-2	dDREF	40170(Tax:7227)	34328(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA-binding activity .
15695365	0	Mi-2	27,31	p66	56,59	Mi-2	p66	40170(Tax:7227)	39212(Tax:7227)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Developmental roles of the Mi-2 / NURD-associated protein p66 in Drosophila .
14530259	0	Mi-2_beta	0,9	BRG1	26,30	Mi-2 beta	BRG1	1108	6597	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Mi-2_beta associates with BRG1 and RET_finger_protein at the distinct regions with transcriptional activating and repressing abilities .
23815345	0	Mi2	35,38	LET-418	27,34	Mi2	LET-418	40170(Tax:7227)	178970(Tax:6239)	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	The Caenorhabditis_elegans LET-418 / Mi2 plays a conserved role in lifespan regulation .
23921378	0	MiD49	17,22	Mff	58,61	MiD49	Mff	125170	56947	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission .
21643017	0	MiR-100	0,7	RBSP3	65,70	MiR-100	RBSP3	406892	10217	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-100 regulates cell differentiation and survival by targeting RBSP3 , a phosphatase-like tumor suppressor in acute myeloid_leukemia .
23904379	0	MiR-106a	0,8	Mcl-1	17,22	MiR-106a	Mcl-1	406899	4170	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MiR-106a targets Mcl-1 to suppress cisplatin resistance of ovarian_cancer A2780 cells .
25851994	0	MiR-107	0,7	SIAH1	23,28	MiR-107	SIAH1	406901	6477	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	MiR-107 down-regulates SIAH1 expression in human breast_cancer cells and silencing of miR-107 inhibits tumor growth in a nude mouse model of triple-negative_breast_cancer .
23056576	0	MiR-122	0,7	IGF1R	84,89	MiR-122	IGF1R	406906	3480	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-122 inhibits cell proliferation and tumorigenesis of breast_cancer by targeting IGF1R .
20460050	0	MiR-122	1,8	PEG10	37,42	MiR-122	PEG10	406906	23089	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	-LSB- MiR-122 regulates the expression of PEG10 in hepatoma cell lines -RSB- .
24806621	0	MiR-1246	0,8	thrombospondin_2	122,138	MiR-1246	thrombospondin 2	100302142	7058	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	MiR-1246 promotes SiHa_cervical_cancer cell proliferation , invasion , and migration through suppression of its target gene thrombospondin_2 .
25027343	0	MiR-126	0,7	Crk	74,77	MiR-126	Crk	406913	1398	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-126 inhibits the invasion of gastric_cancer cell in part by targeting Crk .
24924687	0	MiR-132	0,7	SIRT1	31,36	MiR-132	SIRT1	406921	23411	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic pathway .
26845040	0	MiR-133a	24,32	AMPK	64,68	MiR-133a	AMPK	100314030(Tax:10116)	78975(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Adiponectin Upregulates MiR-133a in Cardiac_Hypertrophy through AMPK Activation and Reduced ERK1/2 Phosphorylation .
21769867	0	MiR-133a	0,8	collagen_1A1	19,31	MiR-133a	collagen 1A1	100314030(Tax:10116)	29393(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-133a regulates collagen_1A1 : potential role of miR-133a in myocardial_fibrosis in angiotensin_II-dependent hypertension .
25414595	0	MiR-133b	0,8	Bcl-w	80,85	MiR-133b	Bcl-w	442890	599	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-133b regulates bladder_cancer cell proliferation and apoptosis by targeting Bcl-w and Akt1 .
24959893	0	MiR-133b	0,8	TAGLN2	55,61	MiR-133b	TAGLN2	723817(Tax:10090)	21346(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MiR-133b regulates the expression of the Actin protein TAGLN2 during oocyte growth and maturation : a potential target for infertility therapy .
22967897	0	MiR-136	0,7	AEG-1	56,61	MiR-136	AEG-1	406927	92140	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2 .
25139024	0	MiR-136	0,7	E2F1	16,20	MiR-136	E2F1	406927	1869	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells .
25939439	0	MiR-137	0,7	EZH2	89,93	MiR-137	EZH2	406928	2146	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-137 inhibits proliferation and angiogenesis of human glioblastoma cells by targeting EZH2 .
23400681	0	MiR-137	0,7	KDM1A	75,80	MiR-137	KDM1A	406928	23028	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A .
24318902	0	MiR-139	0,7	CXCR4	16,21	MiR-139	CXCR4	406931	7852	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MiR-139 targets CXCR4 and inhibits the proliferation and metastasis of laryngeal_squamous_carcinoma cells .
23551751	0	MiR-139	0,7	Mcl-1	17,22	MiR-139	Mcl-1	406931	4170	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	MiR-139 inhibits Mcl-1 expression and potentiates TMZ-induced apoptosis in glioma .
24551096	0	MiR-141	0,7	Tiam1	72,77	MiR-141	Tiam1	406933	7074	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1 .
25474488	0	MiR-143	0,7	IGF1R	29,34	MiR-143	IGF1R	406935	3480	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal_cancer .
26806810	0	MiR-143	0,7	STAT3	68,73	MiR-143	STAT3	406935	6774	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal_squamous_cell_carcinoma .
24448023	0	MiR-144	0,7	meis1	70,75	MiR-144	meis1	100033668(Tax:7955)	170446(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development .
21289483	0	MiR-145	0,7	EGFR	78,82	MiR-145	EGFR	406937	1956	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-145 inhibits cell proliferation of human lung_adenocarcinoma by targeting EGFR and NUDT1 .
22766504	0	MiR-145	0,7	PAK4	18,22	MiR-145	PAK4	406937	10298	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells .
23974950	0	MiR-146a	0,8	IL-6	19,23	MiR-146a	IL-6	387164(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264 .7 macrophage cells by inhibiting Notch1 .
21773870	0	MiR-146a	0,8	MUC5AC	58,64	MiR-146a	MUC5AC	406938	4586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	MiR-146a negatively regulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells .
23974950	0	MiR-146a	0,8	Notch1	105,111	MiR-146a	Notch1	387164(Tax:10090)	18128(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264 .7 macrophage cells by inhibiting Notch1 .
26800097	0	MiR-146a	0,8	Notch1	57,63	MiR-146a	Notch1	406938	4851	Gene	Gene	modulates|nsubj|START_ENTITY modulates|advcl|inhibiting inhibiting|dobj|pathway pathway|amod|END_ENTITY	MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264 .7 macrophages .
23935993	0	MiR-146a	0,8	SOD2	19,23	MiR-146a	SOD2	100314241(Tax:10116)	24787(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	MiR-146a regulates SOD2 expression in H2O2 stimulated PC12 cells .
26396677	0	MiR-146a	0,8	WAVE2	19,24	MiR-146a	WAVE2	387164(Tax:10090)	242687(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	MiR-146a activates WAVE2 expression and enhances phagocytosis in lipopolysaccharide-stimulated RAW264 .7 macrophages .
21455217	0	MiR-148a	0,8	Bcl-2	41,46	MiR-148a	Bcl-2	406940	596	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-148a promotes apoptosis by targeting Bcl-2 in colorectal_cancer .
23975374	0	MiR-148a	0,8	CCKBR	78,83	MiR-148a	CCKBR	406940	887	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-148a regulates the growth and apoptosis in pancreatic_cancer by targeting CCKBR and Bcl-2 .
24515776	0	MiR-148a	0,8	DNA_methyltransferase_1	55,78	MiR-148a	DNA methyltransferase 1	406940	1786	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MiR-148a regulates MEG3 in gastric_cancer by targeting DNA_methyltransferase_1 .
23554686	0	MiR-148a	0,8	ERBB3	44,49	MiR-148a	ERBB3	406940	2065	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-148a inhibits angiogenesis by targeting ERBB3 .
24515776	0	MiR-148a	0,8	MEG3	19,23	MiR-148a	MEG3	406940	55384	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-148a regulates MEG3 in gastric_cancer by targeting DNA_methyltransferase_1 .
26097868	0	MiR-148a	0,8	Neuropilin_1	143,155	MiR-148a	Neuropilin 1	406940	8829	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MiR-148a , a microRNA upregulated in the WNT subgroup tumors , inhibits invasion and tumorigenic potential of medulloblastoma cells by targeting Neuropilin_1 .
20067763	0	MiR-150	0,7	EGR2	94,98	MiR-150	EGR2	406942	1959	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	MiR-150 promotes gastric_cancer proliferation by negatively regulating the pro-apoptotic gene EGR2 .
25190353	0	MiR-152	0,7	FGF2	79,83	MiR-152	FGF2	406943	2247	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|END_ENTITY	MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2 .
27013470	0	MiR-154	0,7	Wnt5a	69,74	MiR-154	Wnt5a	406946	7474	Gene	Gene	Functions|compound|START_ENTITY Functions|nmod|END_ENTITY	MiR-154 Functions as a Tumor Suppressor in Glioblastoma by Targeting Wnt5a .
25601564	0	MiR-155	0,7	TP53INP1	16,24	MiR-155	TP53INP1	406947	94241	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-155 targets TP53INP1 to regulate liver_cancer stem cell acquisition and self-renewal .
22508041	0	MiR-155	0,7	c-Jun	29,34	MiR-155	c-Jun	406947	3725	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MiR-155 negatively regulates c-Jun expression at the post-transcriptional level in human dermal fibroblasts in vitro : implications in UVA irradiation-induced photoaging .
24995320	0	MiR-15b	0,7	cyclin_D1	16,25	MiR-15b	cyclin D1	406949	595	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MiR-15b targets cyclin_D1 to regulate proliferation and apoptosis in glioma cells .
26722459	0	MiR-16	0,6	BCL-2	54,59	MiR-16	BCL-2	51573	596	Gene	Gene	modulate|nsubj|START_ENTITY modulate|advcl|regulating regulating|dobj|END_ENTITY	MiR-16 modulate temozolomide resistance by regulating BCL-2 in human glioma cells .
26592823	0	MiR-16	0,6	amyloid_precursor_protein	64,89	MiR-16	amyloid precursor protein	100313997(Tax:10116)	54226(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-16 regulates cell death in Alzheimer 's _ disease by targeting amyloid_precursor_protein .
22730212	0	MiR-17-5p	0,9	TP53INP1	18,26	MiR-17-5p	TP53INP1	406952	94241	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical_cancer cells .
24345480	0	MiR-181c	0,8	Smad7	98,103	MiR-181c	Smad7	406957	4092	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	MiR-181c modulates the proliferation , migration , and invasion of neuroblastoma cells by targeting Smad7 .
26126858	0	MiR-182	18,25	RASA1	61,66	MiR-182	RASA1	406958	5921	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular_carcinoma .
26805687	0	MiR-184	0,7	GAS1	71,75	MiR-184	GAS1	406960	2619	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-184 regulates proliferation in nucleus pulposus cells by targeting GAS1 .
24894676	0	MiR-186	0,7	ROCK1	16,21	MiR-186	ROCK1	406962	6093	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells .
25969992	0	MiR-187	0,7	ALDH1A3	44,51	MiR-187	ALDH1A3	406963	220	Gene	Gene	Targets|nsubj|START_ENTITY Targets|dobj|END_ENTITY	MiR-187 Targets the Androgen-Regulated Gene ALDH1A3 in Prostate_Cancer .
22265691	0	MiR-18a	0,7	Ptf1a	68,73	MiR-18a	Ptf1a	406953	256297	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells .
26314433	0	MiR-18a	1,8	VP-16	73,78	MiR-18a	VP-16	406953	3054	Gene	Gene	Regulate|nsubj|START_ENTITY Regulate|nmod|END_ENTITY	-LSB- MiR-18a Can Regulate Chemotherapy Sensitivity of Leukemia Cell HL-60 to VP-16 and VCR by Targeting ATM -RSB- .
26191186	0	MiR-191	0,7	DAPK1	112,117	MiR-191	DAPK1	406966	1612	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-191 inhibits TNF-a induced apoptosis of ovarian_endometriosis and endometrioid_carcinoma cells by targeting DAPK1 .
21672525	0	MiR-192	0,7	ERCC3	57,62	MiR-192	ERCC3	406967	2071	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2 .2.15 cells .
25728278	0	MiR-193b	0,8	TGF-beta2	58,67	MiR-193b	TGF-beta2	574455	7042	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|dobj|END_ENTITY	MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway .
24294368	0	MiR-195	0,7	FKN	106,109	MiR-195	FKN	406971	6376	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-195 inhibits proliferation and growth and induces apoptosis of endometrial stromal cells by targeting FKN .
22888524	0	MiR-195	0,7	LATS2	86,91	MiR-195	LATS2	406971	26524	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-195 regulates cell apoptosis of human hepatocellular_carcinoma cells by targeting LATS2 .
26631043	0	MiR-195	0,7	cyclin_D1	88,97	MiR-195	cyclin D1	406971	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-195 inhibits the proliferation of human cervical_cancer cells by directly targeting cyclin_D1 .
25833695	0	MiR-197	0,7	NLK	77,80	MiR-197	NLK	406974	51701	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	MiR-197 induces Taxol resistance in human ovarian_cancer cells by regulating NLK .
25448600	0	MiR-199a-3p	0,11	ZHX1	61,65	MiR-199a-3p	ZHX1	406977	11244	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-199a-3p promotes gastric_cancer progression by targeting ZHX1 .
20501828	0	MiR-199a-3p	0,11	mTOR	22,26	MiR-199a-3p	mTOR	406977	21977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells .
26111969	0	MiR-19a	0,7	PTEN	18,22	MiR-19a	PTEN	723891(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes .
27044840	0	MiR-200b	0,8	FOXG1	89,94	MiR-200b	FOXG1	406984	2290	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	MiR-200b promotes the cell proliferation and metastasis of cervical cancer by inhibiting FOXG1 .
22072420	0	MiR-200b	0,8	Tgf-b	24,29	MiR-200b	Tgf-b	406984	7040	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	MiR-200b is involved in Tgf-b signaling to regulate mammalian palate development .
22615771	0	MiR-200c	0,8	Noxa	19,23	MiR-200c	Noxa	406985	5366	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MiR-200c regulates Noxa expression and sensitivity to proteasomal inhibitors .
25621839	0	MiR-203	0,7	ZNF217	19,25	MiR-203	ZNF217	406986	7764	Gene	Gene	Upregulation|compound|START_ENTITY Upregulation|compound|END_ENTITY	MiR-203 Suppresses ZNF217 Upregulation in Colorectal_Cancer and Its Oncogenicity .
25647033	0	MiR-204	0,7	CyclinD2	123,131	MiR-204	CyclinD2	406987	894	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-204 , down-regulated in retinoblastoma , regulates proliferation and invasion of human retinoblastoma cells by targeting CyclinD2 and MMP-9 .
26406941	0	MiR-204	0,7	HMGA2	18,23	MiR-204	HMGA2	406987	8091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MiR-204 regulates HMGA2 expression and inhibits cell proliferation in human thyroid_cancer .
23768087	0	MiR-204	0,7	SIRT1	23,28	MiR-204	SIRT1	406987	23411	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition , anoikis resistance and invasion in gastric_cancer cells .
25036738	0	MiR-204	0,7	neuritin	88,96	MiR-204	neuritin	100314051(Tax:10116)	83834(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression .
24929707	0	MiR-205	0,7	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	45,101	MiR-205	phosphatase and tensin homolog deleted on chromosome ten	406988	5728	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-205 inhibits cell apoptosis by targeting phosphatase_and_tensin_homolog_deleted_on_chromosome_ten in endometrial_cancer Ishikawa cells .
23087182	0	MiR-20a	0,7	ASK1	18,22	MiR-20a	ASK1	406982	4217	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MiR-20a regulates ASK1 expression and TLR4-dependent cytokine release in rheumatoid fibroblast-like synoviocytes .
25019203	0	MiR-20a	0,7	LIMK1	102,107	MiR-20a	LIMK1	406982	3984	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-20a inhibits cutaneous_squamous_cell_carcinoma metastasis and proliferation by directly targeting LIMK1 .
25303175	0	MiR-21	0,6	ERK1	32,36	MiR-21	ERK1	406991	5595	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	MiR-21 Simultaneously Regulates ERK1 Signaling in HSC Activation and Hepatocyte EMT in Hepatic_Fibrosis .
23504349	0	MiR-21	0,6	FASL	96,100	MiR-21	FASL	406991	356	Gene	Gene	down-regulation|amod|START_ENTITY suppresses|nsubj|down-regulation suppresses|advcl|targeting targeting|xcomp|genes genes|nsubj|END_ENTITY	MiR-21 down-regulation suppresses cell growth , invasion and induces cell apoptosis by targeting FASL , TIMP3 , and RECK genes in esophageal_carcinoma .
24335017	0	MiR-21	10,16	FasL	38,42	MiR-21	FasL	406991	356	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Impact of MiR-21 on the expression of FasL in the presence of TGF-b1 .
23904372	0	MiR-21	0,6	PDCD4	77,82	MiR-21	PDCD4	406991	27250	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|regulating regulating|dobj|END_ENTITY	MiR-21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2 .
24609942	0	MiR-21	0,6	PDCD4	100,105	MiR-21	PDCD4	406991	27250	Gene	Gene	modulates|nsubj|START_ENTITY modulates|xcomp|cisplatin cisplatin|advcl|targeting targeting|dobj|END_ENTITY	MiR-21 modulates chemosensitivity of tongue_squamous_cell_carcinoma cells to cisplatin by targeting PDCD4 .
24293118	0	MiR-21	0,6	PTEN	69,73	MiR-21	PTEN	406991	5728	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|targeting targeting|dobj|gene gene|compound|END_ENTITY	MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small_cell_lung_cancer A549 cells .
26651881	0	MiR-21	0,6	PTEN	109,113	MiR-21	PTEN	406991	5728	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	MiR-21 modulates human airway smooth muscle cell proliferation and migration in asthma through regulation of PTEN expression .
25803229	0	MiR-21	0,6	PTPN14	107,113	MiR-21	PTPN14	406991	5784	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-21 promotes intrahepatic_cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN .
26400524	0	MiR-21	0,6	SOCS6	45,50	MiR-21	SOCS6	406991	9306	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	MiR-21 and miR-183 can simultaneously target SOCS6 and modulate growth and invasion_of_hepatocellular_carcinoma -LRB- HCC -RRB- cells .
22709411	0	MiR-21	0,6	hTERT	17,22	MiR-21	hTERT	406991	7015	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth .
26244598	0	MiR-210	0,7	NF-kB	17,22	MiR-210	NF-kB	100314053(Tax:10116)	81736(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	MiR-210 inhibits NF-kB signaling pathway by targeting DR6 in osteoarthritis .
26244598	0	MiR-210	0,7	NF-kB	17,22	MiR-210	NF-kB	100314053(Tax:10116)	81736(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	MiR-210 inhibits NF-kB signaling pathway by targeting DR6 in osteoarthritis .
23960236	0	MiR-210	0,7	Oct-2	22,27	MiR-210	Oct-2	387206(Tax:10090)	18987(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	MiR-210 is induced by Oct-2 , regulates B cells , and inhibits autoantibody production .
26823713	0	MiR-211	0,7	SOX4	86,90	MiR-211	SOX4	406993	6659	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MiR-211 inhibits cell proliferation and invasion of gastric_cancer by down-regulating SOX4 .
26872365	0	MiR-214	0,7	FGFR1	86,91	MiR-214	FGFR1	387210(Tax:10090)	14182(Tax:10090)	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	MiR-214 Attenuates Osteogenic Differentiation of Mesenchymal Stem Cells via Targeting FGFR1 .
25575606	0	MiR-214	0,7	VEGF	89,93	MiR-214	VEGF	406996	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-214 regulates the pathogenesis of patients with coronary_artery_disease by targeting VEGF .
22962603	0	MiR-214	0,7	b-catenin	16,25	MiR-214	b-catenin	406996	1499	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MiR-214 targets b-catenin pathway to suppress invasion , stem-like traits and recurrence of human hepatocellular_carcinoma .
24495805	0	MiR-22	0,6	CD151	87,92	MiR-22	CD151	407004	977	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|END_ENTITY	MiR-22 suppresses the proliferation and invasion of gastric_cancer cells by inhibiting CD151 .
26556862	0	MiR-221	0,7	DNMT3b	62,68	MiR-221	DNMT3b	407006	1789	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MiR-221 promotes stemness of breast_cancer cells by targeting DNMT3b .
24286315	0	MiR-221	0,7	PTEN	100,104	MiR-221	PTEN	407006	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive_breast_cancers by targeting PTEN .
25888377	0	MiR-223	0,7	FBXW7	111,116	MiR-223	FBXW7	407008	55294	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|resistance resistance|nmod|cells cells|acl|regulating regulating|advcl|targeting targeting|dobj|END_ENTITY	MiR-223 promotes the cisplatin resistance of human gastric_cancer cells via regulating cell cycle by targeting FBXW7 .
25888377	0	MiR-223	0,7	FBXW7	111,116	MiR-223	FBXW7	407008	55294	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|resistance resistance|nmod|cells cells|acl|regulating regulating|advcl|targeting targeting|dobj|END_ENTITY	MiR-223 promotes the cisplatin resistance of human gastric_cancer cells via regulating cell cycle by targeting FBXW7 .
22752005	0	MiR-23a	0,7	E-cadherin	79,89	MiR-23a	E-cadherin	407010	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-23a regulates TGF-b-induced epithelial-mesenchymal transition by targeting E-cadherin in lung_cancer cells .
26748386	0	MiR-23b	0,7	TGF-b1	17,23	MiR-23b	TGF-b1	407011	7040	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	MiR-23b controls TGF-b1 induced airway_smooth_muscle cell proliferation via TGFbR2/p-Smad 3 signals .
22076535	0	MiR-25	0,6	Bim	40,43	MiR-25	Bim	407014	10018	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-25 regulates apoptosis by targeting Bim in human ovarian_cancer .
25179841	0	MiR-25	0,6	LATS2	71,76	MiR-25	LATS2	407014	26524	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-25 promotes ovarian_cancer proliferation and motility by targeting LATS2 .
25764156	0	MiR-25	0,6	Mitochondrial_Calcium_Uniporter	73,104	MiR-25	Mitochondrial Calcium Uniporter	407014	90550	Gene	Gene	Cardiomyocytes|compound|START_ENTITY Damage|nsubj|Cardiomyocytes Damage|advcl|Targeting Targeting|dobj|END_ENTITY	MiR-25 Protects Cardiomyocytes against Oxidative Damage by Targeting the Mitochondrial_Calcium_Uniporter .
22912667	0	MiR-25	0,6	Wwp2	17,21	MiR-25	Wwp2	723926(Tax:10090)	66894(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs .
26191168	0	MiR-26b	0,7	EphA2	99,104	MiR-26b	EphA2	407017	1969	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MiR-26b inhibits hepatocellular_carcinoma cell proliferation , migration , and invasion by targeting EphA2 .
24086481	0	MiR-27a	0,7	PI3K	67,71	MiR-27a	PI3K	407018	5293	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K .
24625818	0	MiR-27a	0,7	sFRP1	16,21	MiR-27a	sFRP1	407018	6422	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-27a targets sFRP1 in hFOB cells to regulate proliferation , apoptosis and differentiation .
24390089	0	MiR-27b	0,7	LIMK1	16,21	MiR-27b	LIMK1	407019	3984	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-27b targets LIMK1 to inhibit growth and invasion of NSCLC cells .
21638050	0	MiR-28	0,6	Nrf2	17,21	MiR-28	Nrf2	407020	4780	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism .
21471522	0	MiR-29a	0,7	MCL-1	114,119	MiR-29a	MCL-1	387222(Tax:10090)	17210(Tax:10090)	Gene	Gene	down-regulation|amod|START_ENTITY contributes|nsubj|down-regulation contributes|xcomp|apoptosis apoptosis|nmod|overexpression overexpression|compound|END_ENTITY	MiR-29a down-regulation in ALK-positive anaplastic_large_cell_lymphomas contributes to apoptosis blockade through MCL-1 overexpression .
25549087	0	MiR-29a	0,7	TIMP-1	16,22	MiR-29a	TIMP-1	407021	7076	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-b Activated Kinase 1 Binding Protein 1 , Implications for Systemic_Sclerosis .
26766915	0	MiR-29c	0,7	ITGB1	88,93	MiR-29c	ITGB1	407026	3688	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-29c inhibits cell growth , invasion , and migration of pancreatic_cancer by targeting ITGB1 .
26990571	0	MiR-301a	0,8	E-cadherin	19,29	MiR-301a	E-cadherin	407027	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MiR-301a regulates E-cadherin expression and is predictive of prostate_cancer recurrence .
25790935	0	MiR-301a	0,8	PTEN	99,103	MiR-301a	PTEN	407027	5728	Gene	Gene	Mediates|nsubj|START_ENTITY Mediates|nmod|Expression Expression|compound|END_ENTITY	MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression .
25501305	0	MiR-30a	8,15	Angiotensin_II	54,68	MiR-30a	Angiotensin II	100314011(Tax:10116)	24179(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of MiR-30a in cardiomyocyte autophagy induced by Angiotensin_II .
25621074	0	MiR-30a	0,7	IER3	28,32	MiR-30a	IER3	407029	8870	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	MiR-30a upregulates BCL2A1 , IER3 and cyclin_D2 expression by targeting FOXL2 .
27006279	0	MiR-30a	0,7	IL-21R	85,91	MiR-30a	IL-21R	387225(Tax:10090)	60504(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-30a inhibits Th17 differentiation and demyelination of EAE mice by targeting the IL-21R .
25264196	0	MiR-30a	0,7	RunX2	41,46	MiR-30a	RunX2	407029	860	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-30a inhibits osteolysis by targeting RunX2 in giant_cell_tumor_of_bone .
26449831	0	MiR-30a	0,7	Runx2	96,101	MiR-30a	Runx2	407029	860	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MiR-30a regulates the proliferation , migration , and invasion of human osteosarcoma by targeting Runx2 .
26471298	0	MiR-32	0,6	Kruppel-like_factor_4	61,82	MiR-32	Kruppel-like factor 4	407036	9314	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MiR-32 promotes gastric_carcinoma tumorigenesis by targeting Kruppel-like_factor_4 .
23696749	0	MiR-335	14,21	CtIP	30,34	MiR-335	CtIP	442904	5932	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response .
26030758	0	MiR-335	0,7	Hif-1a	18,24	MiR-335	Hif-1a	723930(Tax:10090)	15251(Tax:10090)	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	MiR-335 Regulates Hif-1a to Reduce Cell Death in Both Mouse Cell Line and Rat Ischemic Models .
25492484	0	MiR-335	0,7	c-Met	80,85	MiR-335	c-Met	442904	4233	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-335 inhibits migration of breast_cancer cells through targeting oncoprotein c-Met .
26518874	0	MiR-346	0,7	Argonaute_2	21,32	MiR-346	Argonaute 2	442911	27161	Gene	Gene	Up-regulates|compound|START_ENTITY END_ENTITY|nsubj|Up-regulates	MiR-346 Up-regulates Argonaute_2 -LRB- AGO2 -RRB- Protein Expression to Augment the Activity of Other MiRNAs and Contributes to Cervical_Cancer Cell Malignancy .
22623155	0	MiR-34a	0,7	Bcl-2	89,94	MiR-34a	Bcl-2	407040	596	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	MiR-34a inhibits proliferation and migration_of_breast_cancer through down-regulation of Bcl-2 and SIRT1 .
25910896	0	MiR-34a	0,7	Bcl-2	84,89	MiR-34a	Bcl-2	407040	596	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2 .
24220341	0	MiR-34a	0,7	GAS1	16,20	MiR-34a	GAS1	407040	2619	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary_thyroid_carcinoma via PI3K/Akt/Bad pathway .
25173798	0	MiR-34a	0,7	HDAC1	50,55	MiR-34a	HDAC1	407040	3065	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-34a regulates therapy resistance by targeting HDAC1 and HDAC7 in breast_cancer .
22483937	0	MiR-34a	0,7	Notch1	84,90	MiR-34a	Notch1	723848(Tax:10090)	18128(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-34a inhibits lipopolysaccharide-induced inflammatory response through targeting Notch1 in murine macrophages .
22701667	0	MiR-34a	0,7	Numbl	18,23	MiR-34a	Numbl	723848(Tax:10090)	18223(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	MiR-34a represses Numbl in murine neural_progenitor_cells and antagonizes neuronal differentiation .
20548334	0	MiR-375	0,7	JAK2	92,96	MiR-375	JAK2	494324	3717	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-375 frequently downregulated in gastric_cancer inhibits cell proliferation by targeting JAK2 .
25055044	0	MiR-375	16,23	JAK2	93,97	MiR-375	JAK2	494324	3717	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Snail-regulated MiR-375 inhibits migration and invasion of gastric_cancer cells by targeting JAK2 .
26224477	0	MiR-375	0,7	KLF4	16,20	MiR-375	KLF4	494324	9314	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MiR-375 targets KLF4 and impacts the proliferation of colorectal_carcinoma .
25889255	0	MiR-377	0,7	E2F3	16,20	MiR-377	E2F3	494326	1871	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma .
25889255	0	MiR-377	0,7	E2F3	16,20	MiR-377	E2F3	494326	1871	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma .
25562172	0	MiR-378	0,7	Fus	72,75	MiR-378	Fus	723889(Tax:10090)	233908(Tax:10090)	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|nmod|Expression Expression|compound|END_ENTITY	MiR-378 Promotes the Migration of Liver_Cancer Cells by Down-Regulating Fus Expression .
24139413	0	MiR-378	0,7	MAPK1	80,85	MiR-378	MAPK1	494327	5594	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-378 inhibits progression of human gastric_cancer MGC-803 cells by targeting MAPK1 in vitro .
26450928	0	MiR-381	0,7	Cx43	36,40	MiR-381	Cx43	494330	2697	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	MiR-381 suppresses C/EBPa-dependent Cx43 expression in breast_cancer cells .
26800338	0	MiR-382	0,7	NR2F2	55,60	MiR-382	NR2F2	494331	7026	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-382 inhibits cell growth and invasion by targeting NR2F2 in colorectal_cancer .
23227829	0	MiR-383	0,7	peroxiredoxin_3	56,71	MiR-383	peroxiredoxin 3	494332	10935	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|END_ENTITY	MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin_3 -LRB- PRDX3 -RRB- .
23801117	0	MiR-424	0,7	CDX2	95,99	MiR-424	CDX2	494336	1045	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-424 regulates monocytic differentiation of human leukemia U937 cells by directly targeting CDX2 .
23999873	0	MiR-429	0,7	Bcl-2	77,82	MiR-429	Bcl-2	554210	596	Gene	Gene	up-regulation|amod|START_ENTITY induces|nsubj|up-regulation induces|advcl|targeting targeting|dobj|END_ENTITY	MiR-429 up-regulation induces apoptosis and suppresses invasion by targeting Bcl-2 and SP-1 in esophageal_carcinoma .
26511969	0	MiR-429	0,7	Bcl-2	55,60	MiR-429	Bcl-2	554210	596	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	MiR-429 induces apoptosis of glioblastoma cell through Bcl-2 .
26513239	0	MiR-429	0,7	Bcl-2	57,62	MiR-429	Bcl-2	554210	596	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|dep|END_ENTITY	MiR-429 Induces Gastric_Carcinoma Cell Apoptosis Through Bcl-2 .
26934316	0	MiR-449a	0,8	CRIP2	57,62	MiR-449a	CRIP2	554213	1397	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-449a promotes breast_cancer progression by targeting CRIP2 .
26609480	0	MiR-449a	0,8	MAP2K1	48,54	MiR-449a	MAP2K1	554213	5604	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|END_ENTITY	MiR-449a suppresses cell invasion by inhibiting MAP2K1 in non-small_cell_lung_cancer .
26019450	0	MiR-451	0,7	CDKN2D	85,91	MiR-451	CDKN2D	574411	1032	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-451 inhibits proliferation of esophageal_carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1 .
26019450	0	MiR-451	0,7	CDKN2D	85,91	MiR-451	CDKN2D	574411	1032	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-451 inhibits proliferation of esophageal_carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1 .
25391425	0	MiR-451	0,7	CXCL16	55,61	MiR-451	CXCL16	574411	58191	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-451 inhibits cell growth and invasion by targeting CXCL16 and is associated with prognosis of osteosarcoma patients .
24138931	0	MiR-451	0,7	MIF	55,58	MiR-451	MIF	574411	4282	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-451 inhibits cell growth and invasion by targeting MIF and is associated with survival in nasopharyngeal_carcinoma .
25756961	0	MiR-4689	40,48	KRAS	24,28	MiR-4689	KRAS	100616421	3845	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal_Cancer .
24686007	0	MiR-489	0,7	Akt3	82,86	MiR-489	Akt3	574442	10000	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	MiR-489 modulates cisplatin resistance in human ovarian_cancer cells by targeting Akt3 .
23012423	0	MiR-494	0,7	ERK1/2	24,30	MiR-494	ERK1/2	574452	5595;5594	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell_lung_cancer through BIM down-regulation .
24293376	0	MiR-495	0,7	MTA3	68,72	MiR-495	MTA3	574453	57504	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3 .
24667580	0	MiR-497	62,69	IGF-1R	39,45	MiR-497	IGF-1R	574456	3480	Gene	Gene	levels|compound|START_ENTITY target|nmod|levels Insulin-like_growth_factor_1_receptor|nmod|target Insulin-like_growth_factor_1_receptor|appos|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic_cancer .
24667580	0	MiR-497	62,69	IGF-1R	81,87	MiR-497	IGF-1R	574456	3480	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- as a target of MiR-497 and plasma IGF-1R levels associated with TNM stage of pancreatic_cancer .
26336827	0	MiR-497	0,7	VEGFA	89,94	MiR-497	VEGFA	751537(Tax:10090)	22339(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|END_ENTITY	MiR-497 suppresses angiogenesis and metastasis of hepatocellular_carcinoma by inhibiting VEGFA and AEG-1 .
26159783	0	MiR-499	0,7	Polymerase_b	95,107	MiR-499	Polymerase b	574501	5423	Gene	Gene	Enhances|nsubj|START_ENTITY Enhances|nmod|END_ENTITY	MiR-499 Enhances the Cisplatin Sensitivity of Esophageal_Carcinoma Cell Lines by Targeting DNA Polymerase_b .
24931256	0	MiR-503	0,7	IGF1R	87,92	MiR-503	IGF1R	574506	3480	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-503 regulates cisplatin resistance of human gastric_cancer cell lines by targeting IGF1R and BCL2 .
24550137	0	MiR-503	0,7	p85	21,24	MiR-503	p85	574506	5296	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MiR-503 targets PI3K p85 and IKK-b and suppresses progression of non-small cell lung_cancer .
25856555	0	MiR-506	0,7	FOXQ1	65,70	MiR-506	FOXQ1	574511	94234	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|nmod|END_ENTITY	MiR-506 Suppresses Tumor Proliferation and Invasion by Targeting FOXQ1 in Nasopharyngeal_Carcinoma .
25608840	0	MiR-511	0,7	PIK3R3	92,98	MiR-511	PIK3R3	574445	8503	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-511 inhibits growth and metastasis of human hepatocellular_carcinoma cells by targeting PIK3R3 .
26206083	0	MiR-539	0,7	CARMA1	82,88	MiR-539	CARMA1	664612	84433	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-539 inhibits thyroid_cancer cell migration and invasion by directly targeting CARMA1 .
24355664	0	MiR-568	0,7	CD4	48,51	MiR-568	CD4	693153	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activation activation|nmod|cells cells|compound|END_ENTITY	MiR-568 inhibits the activation and function of CD4 T cells and Treg cells by targeting NFAT5 .
24355664	0	MiR-568	0,7	NFAT5	91,96	MiR-568	NFAT5	693153	10725	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-568 inhibits the activation and function of CD4 T cells and Treg cells by targeting NFAT5 .
26629010	0	MiR-592	0,7	FOXO3	18,23	MiR-592	FOXO3	693177	2309	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	MiR-592 represses FOXO3 expression and promotes the proliferation of prostate_cancer cells .
26498682	0	MiR-652	0,7	ZEB1	123,127	MiR-652	ZEB1	724022	6935	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-652 inhibits acidic microenvironment-induced epithelial-mesenchymal transition of pancreatic_cancer cells by targeting ZEB1 .
26585488	0	MiR-661	0,7	hTERT	80,85	MiR-661	hTERT	724031	7015	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-661 inhibits glioma cell proliferation , migration and invasion by targeting hTERT .
25148573	0	MiR-663	0,7	TGFB1	66,71	MiR-663	TGFB1	724033	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode .
25483041	0	MiR-663	0,7	TGFB1	66,71	MiR-663	TGFB1	724033	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode .
26877865	0	MiR-690	0,7	p65	128,131	MiR-690	p65	751543(Tax:10090)	19697(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiR-690 , a Runx2-targeted miRNA , regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65 .
25181544	0	MiR-7	0,5	KLF4	80,84	MiR-7	KLF4	10859	9314	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-7 promotes epithelial cell transformation by targeting the tumor suppressor KLF4 .
25070049	0	MiR-7	0,5	SETDB1	65,71	MiR-7	SETDB1	10859	9869	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	MiR-7 , inhibited indirectly by lincRNA HOTAIR , directly inhibits SETDB1 and reverses the EMT of breast_cancer stem cells by downregulating the STAT3 pathway .
26932538	0	MiR-708	0,7	SMAD3	115,120	MiR-708	SMAD3	100126333	4088	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-708 promotes steroid-induced osteonecrosis of femoral head , suppresses osteogenic differentiation by targeting SMAD3 .
24815691	0	MiR-718	0,7	VEGF	18,22	MiR-718	VEGF	100313781	7422	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	MiR-718 represses VEGF and inhibits ovarian_cancer cell progression .
25961434	0	MiR-744	0,7	ARHGAP5	124,131	MiR-744	ARHGAP5	100126313	394	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	MiR-744 functions as a proto-oncogene in nasopharyngeal_carcinoma progression and metastasis via transcriptional control of ARHGAP5 .
25531331	0	MiR-873	0,7	ERa	18,21	MiR-873	ERa	100126316	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	MiR-873 regulates ERa transcriptional activity and tamoxifen resistance via targeting CDK3 in breast_cancer cells .
26202215	0	MiR-873	0,7	ERa	18,21	MiR-873	ERa	100126316	26284	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	MiR-873 regulates ERa transcriptional activity and tamoxifen resistance via targeting CDK3 in breast_cancer cells .
26202215	0	MiR-873	0,7	ERa	18,21	MiR-873	ERa	100126316	26284	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	MiR-873 regulates ERa transcriptional activity and tamoxifen resistance via targeting CDK3 in breast_cancer cells .
24462679	0	MiR-874	0,7	AQP3	66,70	MiR-874	AQP3	100126343	360	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiR-874 promotes intestinal_barrier_dysfunction through targeting AQP3 following intestinal ischemic_injury .
22761336	0	MiR-96	0,6	REV1	21,25	MiR-96	REV1	407053	51455	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition .
26884926	0	MiR-98	0,6	PAK1	101,105	MiR-98	PAK1	407054	5058	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiR-98 inhibits cell proliferation and invasion of non-small_cell_carcinoma_lung_cancer by targeting PAK1 .
23594994	0	MiR199b	0,7	HIF-1a	62,68	MiR199b	HIF-1a	406978	3091	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	MiR199b Suppresses Expression of Hypoxia-Inducible_Factor_1a -LRB- HIF-1a -RRB- in Prostate_Cancer Cells .
23594994	0	MiR199b	0,7	Hypoxia-Inducible_Factor_1a	33,60	MiR199b	Hypoxia-Inducible Factor 1a	406978	3091	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	MiR199b Suppresses Expression of Hypoxia-Inducible_Factor_1a -LRB- HIF-1a -RRB- in Prostate_Cancer Cells .
26610487	0	MiR542-3p	0,9	BMP7	80,84	MiR542-3p	BMP7	104797379	85272(Tax:10116)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|nmod|END_ENTITY	MiR542-3p Regulates the Epithelial-Mesenchymal Transition by Directly Targeting BMP7 in NRK52e .
25234715	0	MiR99a	0,6	MMP7	17,21	MiR99a	MMP7	407055	4316	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	MiR99a modulates MMP7 and MMP13 to regulate invasiveness of Kaposi 's _ sarcoma .
26755652	0	MiRNA-133b	0,10	GLI3	79,83	MiRNA-133b	GLI3	442890	2737	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3 .
26261520	0	MiRNA-15a	0,9	TNFAIP1	70,77	MiRNA-15a	TNFAIP1	406948	7126	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MiRNA-15a inhibits proliferation , migration and invasion by targeting TNFAIP1 in human osteosarcoma cells .
21743293	0	MiRNA-20a	0,9	BMP	95,98	MiRNA-20a	BMP	406982	649	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MiRNA-20a promotes osteogenic differentiation of human mesenchymal stem cells by co-regulating BMP signaling .
26396669	0	MiRNA-29c	0,9	CDK6	58,62	MiRNA-29c	CDK6	407026	1021	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MiRNA-29c regulates cell growth and invasion by targeting CDK6 in bladder_cancer .
12185453	0	MiRP1	65,70	KCNE2	58,63	MiRP1	KCNE2	9992	9992	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Identification and functional characterization of a novel KCNE2 -LRB- MiRP1 -RRB- mutation that alters HERG channel kinetics .
16181637	0	Mia40	57,62	Erv1	36,40	Mia40	Erv1	853639(Tax:4932)	852916(Tax:4932)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins .
20367271	0	Mia40	66,71	Erv1	120,124	Mia40	Erv1	853639(Tax:4932)	852916(Tax:4932)	Gene	Gene	affinity|nmod|START_ENTITY transfer|amod|affinity determines|dobj|transfer determines|nmod|core core|amod|END_ENTITY	The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria .
20367271	0	Mia40	66,71	Erv1	33,37	Mia40	Erv1	853639(Tax:4932)	852916(Tax:4932)	Gene	Gene	affinity|nmod|START_ENTITY transfer|amod|affinity determines|dobj|transfer determines|nsubj|domain domain|nmod|END_ENTITY	The N-terminal shuttle domain of Erv1 determines the affinity for Mia40 and mediates electron transfer to the catalytic Erv1 core in yeast mitochondria .
25795303	0	Mib1	24,28	Plk4	39,43	Mib1	Plk4	57534	10733	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis .
20533548	0	Micro-RNA-21	0,12	PDCD4	80,85	Micro-RNA-21	PDCD4	406991	27250	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	Micro-RNA-21 regulates TGF-b-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction .
25501551	0	Micro-RNA_21	0,12	SMAD7	27,32	Micro-RNA 21	SMAD7	406991	4092	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Micro-RNA_21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic_steatohepatitis .
19506341	0	MicroRNA-1	0,10	Bcl-2	58,63	MicroRNA-1	Bcl-2	100314077(Tax:10116)	24224(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2 .
24317814	0	MicroRNA-100	0,12	Cyr61	67,72	MicroRNA-100	Cyr61	406892	3491	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MicroRNA-100 inhibits osteosarcoma cell proliferation by targeting Cyr61 .
25109390	0	MicroRNA-100	0,12	mammalian_target_of_rapamycin	53,82	MicroRNA-100	mammalian target of rapamycin	406892	2475	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-100 promotes migration and invasion through mammalian_target_of_rapamycin in esophageal_squamous_cell_carcinoma .
21068409	0	MicroRNA-101	0,12	MAPK_phosphatase-1	21,39	MicroRNA-101	MAPK phosphatase-1	387143(Tax:10090)	19252(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MicroRNA-101 targets MAPK_phosphatase-1 to regulate the activation of MAPKs in macrophages .
24440352	0	MicroRNA-106a	0,13	TIMP2	22,27	MicroRNA-106a	TIMP2	406899	7077	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-106a targets TIMP2 to regulate invasion and metastasis of gastric_cancer .
26223867	0	MicroRNA-106b	0,13	DLC1	91,95	MicroRNA-106b	DLC1	406900	10395	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-106b promotes colorectal_cancer cell migration and invasion by directly targeting DLC1 .
24842611	0	MicroRNA-106b	0,13	PTEN	117,121	MicroRNA-106b	PTEN	406900	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-106b in cancer-associated fibroblasts from gastric_cancer promotes cell migration and invasion by targeting PTEN .
26053181	0	MicroRNA-106b	0,13	RANKL	70,75	MicroRNA-106b	RANKL	723925(Tax:10090)	21943(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-106b inhibits osteoclastogenesis and osteolysis by targeting RANKL in giant_cell_tumor_of_bone .
23912048	0	MicroRNA-106b	0,13	RUNX3	45,50	MicroRNA-106b	RUNX3	406900	864	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal_carcinoma cells .
26294080	0	MicroRNA-107	0,12	Dicer-1	66,73	MicroRNA-107	Dicer-1	100314022(Tax:10116)	299284(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1 .
22528944	0	MicroRNA-10b	0,12	CADM1	53,58	MicroRNA-10b	CADM1	406903	23705	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-10b promotes migration and invasion through CADM1 in human hepatocellular_carcinoma cells .
21419107	0	MicroRNA-10b	0,12	HOXD10	87,93	MicroRNA-10b	HOXD10	406903	3236	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|modulating modulating|dobj|expression expression|nmod|END_ENTITY	MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10 .
24376640	0	MicroRNA-10b	0,12	HOXD10	96,102	MicroRNA-10b	HOXD10	406903	3236	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc_degeneration .
26311318	0	MicroRNA-10b	0,12	Hoxd10	53,59	MicroRNA-10b	Hoxd10	406903	3236	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-10b promotes migration and invasion through Hoxd10 in human gastric_cancer .
20075075	0	MicroRNA-10b	0,12	KLF4	53,57	MicroRNA-10b	KLF4	406903	9314	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-10b promotes migration and invasion through KLF4 in human esophageal_cancer cell lines .
24573354	0	MicroRNA-10b	0,12	KLF4	53,57	MicroRNA-10b	KLF4	406903	9314	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder_cancer .
24180482	0	MicroRNA-124-3p	0,15	ROCK1	90,95	MicroRNA-124-3p	ROCK1	406909	6093	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-124-3p inhibits cell migration and invasion in bladder_cancer cells by targeting ROCK1 .
26707908	0	MicroRNA-124-3p	0,15	STAT3	98,103	MicroRNA-124-3p	STAT3	406909	6774	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-124-3p inhibits the growth and metastasis of nasopharyngeal_carcinoma cells by targeting STAT3 .
18474618	0	MicroRNA-126	0,12	HOXA9	23,28	MicroRNA-126	HOXA9	406913	3205	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MicroRNA-126 regulates HOXA9 by binding to the homeobox .
26054677	0	MicroRNA-126	0,12	LAT-1	72,77	MicroRNA-126	LAT-1	406913	8140	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-126 inhibits cell proliferation in gastric_cancer by targeting LAT-1 .
26707641	0	MicroRNA-127-3p	0,15	SETD8	65,70	MicroRNA-127-3p	SETD8	100302165	387893	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells .
26708147	0	MicroRNA-127-5p	0,15	biliverdin_reductase_B	28,50	MicroRNA-127-5p	biliverdin reductase B	100302123	645	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-127-5p targets the biliverdin_reductase_B / nuclear factor-kB pathway to suppress cell growth in hepatocellular_carcinoma cells .
25912876	0	MicroRNA-129-5p	0,15	ETS1	93,97	MicroRNA-129-5p	ETS1	100302178	2113	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-129-5p inhibits hepatocellular_carcinoma cell metastasis and invasion via targeting ETS1 .
27035216	0	MicroRNA-130a	0,13	PTEN	105,109	MicroRNA-130a	PTEN	406919	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN .
24021279	0	MicroRNA-130b	0,13	Fmr1	22,26	MicroRNA-130b	Fmr1	723816(Tax:10090)	14265(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MicroRNA-130b targets Fmr1 and regulates embryonic neural progenitor cell proliferation and differentiation .
20176475	0	MicroRNA-130b	0,13	RUNX3	46,51	MicroRNA-130b	RUNX3	406920	864	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric_cancer .
25387077	0	MicroRNA-130b	0,13	peroxisome_proliferator-activated_receptor_gamma	57,105	MicroRNA-130b	peroxisome proliferator-activated receptor gamma	406920	5468	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	MicroRNA-130b promotes cell aggressiveness by inhibiting peroxisome_proliferator-activated_receptor_gamma in human hepatocellular_carcinoma .
26653558	0	MicroRNA-130b	0,13	peroxisome_proliferator-activated_receptor_gamma	64,112	MicroRNA-130b	peroxisome proliferator-activated receptor gamma	406920	5468	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-130b promotes cell migration and invasion by targeting peroxisome_proliferator-activated_receptor_gamma in human glioma .
25547017	0	MicroRNA-130b	0,13	peroxisome_proliferator-activated_receptor_y	58,102	MicroRNA-130b	peroxisome proliferator-activated receptor y	406920	5468	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-130b regulates scleroderma fibrosis by targeting peroxisome_proliferator-activated_receptor_y .
26617770	0	MicroRNA-133b	0,13	Akt	82,85	MicroRNA-133b	Akt	442890	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MicroRNA-133b inhibits proliferation and invasion of ovarian_cancer cells through Akt and Erk1/2 inactivation by targeting epidermal_growth_factor_receptor .
23810756	0	MicroRNA-133b	0,13	Foxl2	66,71	MicroRNA-133b	Foxl2	442890	668	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2 .
22883469	0	MicroRNA-133b	0,13	epidermal_growth_factor_receptor	81,113	MicroRNA-133b	epidermal growth factor receptor	442890	1956	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-133b inhibits the growth of non-small-cell_lung_cancer by targeting the epidermal_growth_factor_receptor .
26617770	0	MicroRNA-133b	0,13	epidermal_growth_factor_receptor	123,155	MicroRNA-133b	epidermal growth factor receptor	442890	1956	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-133b inhibits proliferation and invasion of ovarian_cancer cells through Akt and Erk1/2 inactivation by targeting epidermal_growth_factor_receptor .
26722242	0	MicroRNA-133b	0,13	matrix_metalloproteinase_14	64,91	MicroRNA-133b	matrix metalloproteinase 14	442890	4323	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-133b inhibits cell migration and invasion by targeting matrix_metalloproteinase_14 in glioblastoma .
25537516	0	MicroRNA-135b	0,13	HSF1	17,21	MicroRNA-135b	HSF1	442891	3297	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	MicroRNA-135b , a HSF1 target , promotes tumor invasion and metastasis by regulating RECK and EVI5_in_hepatocellular_carcinoma .
26101704	0	MicroRNA-135b	0,13	large_tumor_suppressor_kinase_2	88,119	MicroRNA-135b	large tumor suppressor kinase 2	442891	26524	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MicroRNA-135b regulates apoptosis and chemoresistance in colorectal_cancer by targeting large_tumor_suppressor_kinase_2 .
25190111	0	MicroRNA-135b	0,13	myocardin	96,105	MicroRNA-135b	myocardin	442891	93649	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-135b promotes proliferation , invasion and migration of osteosarcoma cells by degrading myocardin .
26566162	0	MicroRNA-137	0,12	CDC42	79,84	MicroRNA-137	CDC42	406928	998	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|dep|END_ENTITY	MicroRNA-137 Negatively Regulates H2O2-Induced Cardiomyocyte Apoptosis Through CDC42 .
24412084	0	MicroRNA-137	0,12	KIT	28,31	MicroRNA-137	KIT	406928	3815	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	MicroRNA-137 down-regulates KIT and inhibits small_cell_lung_cancer cell proliferation .
24084696	0	MicroRNA-137	0,12	Klf4	23,27	MicroRNA-137	Klf4	387155(Tax:10090)	16600(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	MicroRNA-137 represses Klf4 and Tbx3 during differentiation of mouse embryonic stem cells .
26617798	0	MicroRNA-137	0,12	bone_morphogenetic_protein-7	63,91	MicroRNA-137	bone morphogenetic protein-7	406928	655	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-137 inhibits cell migration and invasion by targeting bone_morphogenetic_protein-7 -LRB- BMP7 -RRB- in non-small_cell_lung_cancer cells .
26787707	0	MicroRNA-140	0,12	iASPP	95,100	MicroRNA-140	iASPP	406932	10848	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-140 regulates cell growth and invasion in pancreatic_duct_adenocarcinoma by targeting iASPP .
24722758	0	MicroRNA-143	0,12	Syndecan-1	21,31	MicroRNA-143	Syndecan-1	406935	6382	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MicroRNA-143 targets Syndecan-1 to repress cell growth in melanoma .
26309510	0	MicroRNA-145	0,12	DUSP6	82,87	MicroRNA-145	DUSP6	406937	1848	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-145 inhibits human papillary cancer TPC1 cell proliferation by targeting DUSP6 .
25277192	0	MicroRNA-145	0,12	MUC13	21,26	MicroRNA-145	MUC13	406937	56667	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic_cancer .
19409607	0	MicroRNA-145	0,12	OCT4	23,27	MicroRNA-145	OCT4	406937	5460	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MicroRNA-145 regulates OCT4 , SOX2 , and KLF4 and represses pluripotency in human embryonic stem cells .
26715279	0	MicroRNA-145	0,12	ROCK1	96,101	MicroRNA-145	ROCK1	406937	6093	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-145 inhibits growth and migration of breast_cancer cells through targeting oncoprotein ROCK1 .
22472569	0	MicroRNA-145	0,12	vascular_endothelial_growth_factor	21,55	MicroRNA-145	vascular endothelial growth factor	406937	7422	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-145 targets vascular_endothelial_growth_factor and inhibits invasion and metastasis of osteosarcoma cells .
26298724	0	MicroRNA-148a	0,13	MMP-13	69,75	MicroRNA-148a	MMP-13	406940	4322	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-148a inhibits migration of breast_cancer cells by targeting MMP-13 .
26707142	0	MicroRNA-148a	0,13	WNT-1	82,87	MicroRNA-148a	WNT-1	406940	7471	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-148a inhibits breast_cancer migration and invasion by directly targeting WNT-1 .
23549984	0	MicroRNA-148a	0,13	runt-related_transcription_factor_3	27,62	MicroRNA-148a	runt-related transcription factor 3	406940	864	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	MicroRNA-148a can regulate runt-related_transcription_factor_3 gene expression via modulation of DNA methyltransferase 1 in gastric_cancer .
24757201	0	MicroRNA-149	0,12	PARP-2	22,28	MicroRNA-149	PARP-2	387167(Tax:10090)	11546(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1 / PGC-1a network in skeletal muscle .
24385540	0	MicroRNA-150	0,12	CCR6	88,92	MicroRNA-150	CCR6	387168(Tax:10090)	12458(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6 , in advanced cutaneous_T-cell_lymphoma .
23125218	0	MicroRNA-152	0,12	DNA_methyltransferase_1	21,44	MicroRNA-152	DNA methyltransferase 1	406943	1786	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-152 targets DNA_methyltransferase_1 in NiS-transformed cells via a feedback mechanism .
27035278	0	MicroRNA-155	0,12	ARID2	82,87	MicroRNA-155	ARID2	406947	196528	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-155 promotes tumor growth of human hepatocellular_carcinoma by targeting ARID2 .
20452491	0	MicroRNA-155	0,12	CYR61	60,65	MicroRNA-155	CYR61	406947	3491	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	MicroRNA-155 contributes to preeclampsia by down-regulating CYR61 .
20371610	0	MicroRNA-155	0,12	FOXO3a	80,86	MicroRNA-155	FOXO3a	406947	2309	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-155 regulates cell survival , growth , and chemosensitivity by targeting FOXO3a in breast_cancer .
18450484	0	MicroRNA-155	0,12	activation-induced_cytidine_deaminase	40,77	MicroRNA-155	activation-induced cytidine deaminase	387173(Tax:10090)	11628(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MicroRNA-155 is a negative regulator of activation-induced_cytidine_deaminase .
16675453	0	MicroRNA-155	0,12	angiotensin_II_type_1_receptor	29,59	MicroRNA-155	angiotensin II type 1 receptor	406947	185	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-155 regulates human angiotensin_II_type_1_receptor expression in fibroblasts .
20735984	0	MicroRNA-155	0,12	angiotensin_II_type_1_receptor	23,53	MicroRNA-155	angiotensin II type 1 receptor	102465831	81638(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-155 regulates angiotensin_II_type_1_receptor expression and phenotypic differentiation in vascular adventitial fibroblasts .
25898913	0	MicroRNA-181c	0,13	Bcl-2	22,27	MicroRNA-181c	Bcl-2	406957	596	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MicroRNA-181c targets Bcl-2 and regulates mitochondrial morphology in myocardial cells .
25545945	0	MicroRNA-181c	0,13	Toll-like_receptor_4	111,131	MicroRNA-181c	Toll-like receptor 4	406957	7099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like_receptor_4 .
25682742	0	MicroRNA-182	0,12	ANUBL1	64,70	MicroRNA-182	ANUBL1	406958	93550	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric_cancer .
25012722	0	MicroRNA-182	0,12	PDCD4	102,107	MicroRNA-182	PDCD4	406958	27250	Gene	Gene	modulates|nsubj|START_ENTITY modulates|xcomp|cisplatin cisplatin|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-182 modulates chemosensitivity of human non-small_cell_lung_cancer to cisplatin by targeting PDCD4 .
23296900	0	MicroRNA-182	0,12	programmed_cell_death_4	78,101	MicroRNA-182	programmed cell death 4	406958	27250	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-182 promotes cell growth , invasion , and chemoresistance by targeting programmed_cell_death_4 -LRB- PDCD4 -RRB- in human ovarian_carcinomas .
18840437	0	MicroRNA-183	0,12	Ezrin	23,28	MicroRNA-183	Ezrin	406959	7430	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-183 regulates Ezrin expression in lung_cancer cells .
21399664	0	MicroRNA-193a	0,13	c-kit	24,29	MicroRNA-193a	c-kit	406968	3815	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute_myeloid_leukemia .
26020766	0	MicroRNA-193b	0,13	adiponectin	23,34	MicroRNA-193b	adiponectin	574455	9370	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|compound|END_ENTITY	MicroRNA-193b controls adiponectin production in human white_adipose_tissue .
25119742	0	MicroRNA-193b	0,13	amyloid_precursor_protein	32,57	MicroRNA-193b	amyloid precursor protein	574455	351	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MicroRNA-193b is a regulator of amyloid_precursor_protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer 's _ disease .
23807224	0	MicroRNA-195	0,12	ADP-ribosylation_factor-like_protein_2	21,59	MicroRNA-195	ADP-ribosylation factor-like protein 2	406971	402	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MicroRNA-195 targets ADP-ribosylation_factor-like_protein_2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells .
24486218	0	MicroRNA-195	0,12	MYB	105,108	MicroRNA-195	MYB	406971	4602	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-195 inhibits non-small_cell_lung_cancer cell proliferation , migration and invasion by targeting MYB .
23383003	0	MicroRNA-195	0,12	cyclin_D1	84,93	MicroRNA-195	cyclin D1	406971	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin_D1 and cyclin_E1 .
24740565	0	MicroRNA-195	0,12	steroid_receptor_coactivator-3	23,53	MicroRNA-195	steroid receptor coactivator-3	406971	17979(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-195 regulates steroid_receptor_coactivator-3 protein expression in hepatocellular_carcinoma cells .
25936765	0	MicroRNA-19a	0,12	BTG1	110,114	MicroRNA-19a	BTG1	406979	694	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-19a regulates proliferation and apoptosis of castration-resistant_prostate_cancer cells by targeting BTG1 .
20133739	0	MicroRNA-19a	0,12	cyclin_D1	64,73	MicroRNA-19a	cyclin D1	406979	595	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|expression expression|amod|END_ENTITY	MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin_D1 expression in human umbilical vein endothelial cells .
24824927	0	MicroRNA-19b	0,12	Mfn1	21,25	MicroRNA-19b	Mfn1	406980	55669	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-19b targets Mfn1 to inhibit Mfn1-induced apoptosis in osteosarcoma cells .
25797260	0	MicroRNA-200a	0,13	ZEB2	119,123	MicroRNA-200a	ZEB2	406983	9839	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular_carcinoma by decreasing ZEB2 .
22311119	0	MicroRNA-200b	0,13	ZEB2	90,94	MicroRNA-200b	ZEB2	406984	9839	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-200b regulates cell proliferation , invasion , and migration by directly targeting ZEB2 in gastric_carcinoma .
20683643	0	MicroRNA-200b	0,13	cyclin_D1	24,33	MicroRNA-200b	cyclin D1	406984	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-200b regulates cyclin_D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells .
23404117	0	MicroRNA-200b	0,13	oxidation_resistance_1	28,50	MicroRNA-200b	oxidation resistance 1	387243(Tax:10090)	170719(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-200b downregulates oxidation_resistance_1 -LRB- Oxr1 -RRB- expression in the retina of type 1 diabetes model .
24925028	0	MicroRNA-200b	0,13	protein_kinase_Ca	22,39	MicroRNA-200b	protein kinase Ca	406984	5578	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-200b targets protein_kinase_Ca and suppresses triple-negative breast_cancer metastasis .
24204560	0	MicroRNA-200c	0,13	MUC4	42,46	MicroRNA-200c	MUC4	406985	4585	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic_cancer .
26935975	0	MicroRNA-200c	0,13	ZEB2	87,91	MicroRNA-200c	ZEB2	406985	9839	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-200c inhibits the metastasis of non-small_cell_lung_cancer cells by targeting ZEB2 , an epithelial-mesenchymal transition regulator .
25658920	0	MicroRNA-203	41,53	BANF1	0,5	MicroRNA-203	BANF1	406986	8815	Gene	Gene	Downregulated|nmod|START_ENTITY Downregulated|nsubjpass|END_ENTITY	BANF1 Is Downregulated by IRF1-Regulated MicroRNA-203 in Cervical_Cancer .
26137120	0	MicroRNA-203	0,12	Bmi1	71,75	MicroRNA-203	Bmi1	406986	648	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small_cell_lung_cancer .
24270883	0	MicroRNA-203	0,12	PLD2	102,106	MicroRNA-203	PLD2	406986	5338	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-203 inhibits the proliferation and invasion of U251 glioblastoma cells by directly targeting PLD2 .
26136151	0	MicroRNA-203	0,12	Sam68	78,83	MicroRNA-203	Sam68	406986	10657	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68 .
20039258	0	MicroRNA-204	0,12	Runx2	23,28	MicroRNA-204	Runx2	406987	860	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation .
23612742	0	MicroRNA-205	0,12	Bcl2	62,66	MicroRNA-205	Bcl2	406988	596	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	MicroRNA-205 , a novel regulator of the anti-apoptotic protein Bcl2 , is downregulated in prostate_cancer .
22159356	0	MicroRNA-205	0,12	VEGF-A	86,92	MicroRNA-205	VEGF-A	406988	7422	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A .
26692949	0	MicroRNA-205	0,12	cAMP_responsive_element_binding_protein_1	79,120	MicroRNA-205	cAMP responsive element binding protein 1	406988	1385	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	MicroRNA-205 functions as a tumor suppressor in colorectal_cancer by targeting cAMP_responsive_element_binding_protein_1 -LRB- CREB1 -RRB- .
26186594	0	MicroRNA-206	0,12	c-Met	77,82	MicroRNA-206	c-Met	406989	4233	Gene	Gene	START_ENTITY|dep|Inhibition Inhibition|nmod|Progression Progression|nmod|Pathway Pathway|amod|END_ENTITY	MicroRNA-206 : Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway .
21317927	0	MicroRNA-21	0,11	ANP32A	43,49	MicroRNA-21	ANP32A	406991	8125	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4 .
21085192	0	MicroRNA-21	0,11	CD4	26,29	MicroRNA-21	CD4	406991	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	MicroRNA-21 expression in CD4 + T cells is regulated by STAT3 and is pathologically involved in S zary syndrome .
26191606	0	MicroRNA-21	102,113	Carbonic_Anhydrase-II	61,82	MicroRNA-21	Carbonic Anhydrase-II	406991	760	Gene	Gene	Presence|nmod|START_ENTITY END_ENTITY|nmod|Presence	Bile_Acid Conjugated DNA Chimera that Conditionally Inhibits Carbonic_Anhydrase-II in the Presence of MicroRNA-21 .
25966187	0	MicroRNA-21	0,11	FASLG	73,78	MicroRNA-21	FASLG	100314000(Tax:10116)	25385(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG .
25687183	0	MicroRNA-21	0,11	HEPN1	94,99	MicroRNA-21	HEPN1	406991	641654	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 promotes cell proliferation in human hepatocellular_carcinoma partly by targeting HEPN1 .
19559015	0	MicroRNA-21	0,11	LRRFIP1	20,27	MicroRNA-21	LRRFIP1	406991	9208	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme .
19302977	0	MicroRNA-21	0,11	MARCKS	29,35	MicroRNA-21	MARCKS	406991	4082	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate_cancer cells .
21078976	0	MicroRNA-21	0,11	MutS_homolog_2	78,92	MicroRNA-21	MutS homolog 2	406991	4436	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS_homolog_2 -LRB- hMSH2 -RRB- .
19013014	0	MicroRNA-21	0,11	PDCD4	62,67	MicroRNA-21	PDCD4	406991	27250	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G .
19336275	0	MicroRNA-21	0,11	PDCD4	97,102	MicroRNA-21	PDCD4	406991	27250	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|injury_on_cardiac_myocytes injury_on_cardiac_myocytes|nmod|END_ENTITY	MicroRNA-21 protects against the H -LRB- 2 -RRB- O -LRB- 2 -RRB- - induced injury_on_cardiac_myocytes via its target gene PDCD4 .
22526161	0	MicroRNA-21	0,11	PDCD4	130,135	MicroRNA-21	PDCD4	406991	27250	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|programmed_cell_death_protein_4 programmed_cell_death_protein_4|appos|END_ENTITY	MicroRNA-21 correlates with tumorigenesis in malignant_peripheral_nerve_sheath_tumor -LRB- MPNST -RRB- via programmed_cell_death_protein_4 -LRB- PDCD4 -RRB- .
24902663	0	MicroRNA-21	0,11	PDCD4	75,80	MicroRNA-21	PDCD4	406991	27250	Gene	Gene	downregulates|amod|START_ENTITY tumor|nsubj|downregulates tumor|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation , proliferation , and metastasis in renal_cell_carcinoma .
25520758	0	MicroRNA-21	0,11	PDCD4	55,60	MicroRNA-21	PDCD4	406991	27250	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma .
20223231	0	MicroRNA-21	0,11	PTEN	48,52	MicroRNA-21	PTEN	406991	5728	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- represses tumor suppressor PTEN and promotes growth and invasion in non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
21042775	0	MicroRNA-21	0,11	PTEN	148,152	MicroRNA-21	PTEN	406991	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|expression expression|nmod|protein protein|compound|END_ENTITY	MicroRNA-21 promotes the cell proliferation , invasion and migration abilities_in_ovarian_epithelial_carcinomas through inhibiting the expression of PTEN protein .
21820606	0	MicroRNA-21	0,11	PTEN	90,94	MicroRNA-21	PTEN	406991	5728	Gene	Gene	modulates|nsubj|START_ENTITY modulates|xcomp|doxorubicin doxorubicin|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 modulates chemosensitivity of breast_cancer cells to doxorubicin by targeting PTEN .
22956424	0	MicroRNA-21	0,11	PTEN	140,144	MicroRNA-21	PTEN	406991	5728	Gene	Gene	expression|amod|START_ENTITY promotes|nsubj|expression promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- expression promotes growth , metastasis , and chemo - or radioresistance in non-small_cell_lung_cancer cells by targeting PTEN .
23684551	0	MicroRNA-21	0,11	PTEN	23,27	MicroRNA-21	PTEN	406991	5728	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular_carcinoma progression through AKT/ERK pathways .
24342610	0	MicroRNA-21	0,11	PTEN	94,98	MicroRNA-21	PTEN	406991	5728	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|vitro vitro|nmod|PI3K/Akt PI3K/Akt|acl|signaling signaling|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN .
24817011	0	MicroRNA-21	0,11	PTEN	32,36	MicroRNA-21	PTEN	406991	5728	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|hTERT hTERT|nmod|END_ENTITY	MicroRNA-21 regulates hTERT via PTEN in hypertrophic_scar_fibroblasts .
25084400	0	MicroRNA-21	0,11	PTEN	103,107	MicroRNA-21	PTEN	406991	5728	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- regulates cellular proliferation , invasion , migration , and apoptosis by targeting PTEN , RECK and Bcl-2 in lung squamous_carcinoma , Gejiu City , China .
25357050	0	MicroRNA-21	0,11	PTEN	76,80	MicroRNA-21	PTEN	406991	5728	Gene	Gene	affects|nsubj|START_ENTITY affects|advcl|regulating regulating|dobj|expression expression|nmod|END_ENTITY	MicroRNA-21 affects proliferation and apoptosis by regulating expression of PTEN in human keloid fibroblasts .
25603978	0	MicroRNA-21	0,11	PTEN	31,35	MicroRNA-21	PTEN	406991	5728	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|hTERT hTERT|nmod|END_ENTITY	MicroRNA-21 controls hTERT via PTEN in human colorectal_cancer cell proliferation .
17968323	0	MicroRNA-21	0,11	Pdcd4	75,80	MicroRNA-21	Pdcd4	406991	27250	Gene	Gene	downregulates|amod|START_ENTITY tumor|nsubj|downregulates tumor|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion , intravasation and metastasis in colorectal_cancer .
27101583	0	MicroRNA-21	12,23	RASA1	93,98	MicroRNA-21	RASA1	406991	5921	Gene	Gene	Involved|nsubjpass|START_ENTITY Involved|nmod|END_ENTITY	Circulating MicroRNA-21 Is Involved in Lymph Node Metastasis in Cervical_Cancer by Targeting RASA1 .
25520758	0	MicroRNA-21	0,11	Rb1	27,30	MicroRNA-21	Rb1	406991	5925	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma .
21085192	0	MicroRNA-21	0,11	STAT3	55,60	MicroRNA-21	STAT3	406991	6774	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	MicroRNA-21 expression in CD4 + T cells is regulated by STAT3 and is pathologically involved in S zary syndrome .
26383248	0	MicroRNA-21	0,11	TGF-b1	54,60	MicroRNA-21	TGF-b1	406991	7040	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|END_ENTITY	MicroRNA-21 Negatively Regulates Treg Cells Through a TGF-b1 / Smad-Independent Pathway in Patients with Coronary_Heart_Disease .
24577093	0	MicroRNA-21	0,11	Tipe2	87,92	MicroRNA-21	Tipe2	406991	79626	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2 .
22034194	0	MicroRNA-21	0,11	cystathionine_gamma-lyase	28,53	MicroRNA-21	cystathionine gamma-lyase	406991	1491	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	MicroRNA-21 represses human cystathionine_gamma-lyase expression by targeting at specificity_protein-1 in smooth muscle cells .
24817011	0	MicroRNA-21	0,11	hTERT	22,27	MicroRNA-21	hTERT	406991	7015	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MicroRNA-21 regulates hTERT via PTEN in hypertrophic_scar_fibroblasts .
25603978	0	MicroRNA-21	0,11	hTERT	21,26	MicroRNA-21	hTERT	406991	7015	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	MicroRNA-21 controls hTERT via PTEN in human colorectal_cancer cell proliferation .
25059666	0	MicroRNA-21	0,11	insulin-like_growth_factor-binding_protein-3	67,111	MicroRNA-21	insulin-like growth factor-binding protein-3	406991	3486	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP3 -RRB- .
26660281	0	MicroRNA-21	0,11	miR-21	13,19	MicroRNA-21	miR-21	406991	406991	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation .
25216674	0	MicroRNA-21	0,11	p57Kip2	21,28	MicroRNA-21	p57Kip2	406991	1028	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	MicroRNA-21 inhibits p57Kip2 expression in prostate_cancer .
18372920	0	MicroRNA-21	0,11	programmed_cell_death_4	58,81	MicroRNA-21	programmed cell death 4	406991	27250	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|gene gene|amod|END_ENTITY	MicroRNA-21 promotes cell transformation by targeting the programmed_cell_death_4 gene .
24650454	0	MicroRNA-21	0,11	programmed_cell_death_4	87,110	MicroRNA-21	programmed cell death 4	406991	27250	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MicroRNA-21 regulates biological behaviors in papillary_thyroid_carcinoma by targeting programmed_cell_death_4 .
25400316	0	MicroRNA-21	0,11	programmed_cell_death_4	60,83	MicroRNA-21	programmed cell death 4	387140(Tax:10090)	18569(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|gene gene|amod|END_ENTITY	MicroRNA-21 promotes cell growth and migration by targeting programmed_cell_death_4 gene in Kazakh 's esophageal_squamous_cell_carcinoma .
25738901	0	MicroRNA-21	0,11	programmed_cell_death_4	73,96	MicroRNA-21	programmed cell death 4	406991	27250	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|apoptosis apoptosis|nmod|END_ENTITY	MicroRNA-21 , induced by high glucose , modulates macrophage apoptosis via programmed_cell_death_4 .
26531758	0	MicroRNA-21	0,11	smad7	77,82	MicroRNA-21	smad7	406991	4092	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	MicroRNA-21 induces breast_cancer cell invasion and migration by suppressing smad7 via EGF and TGF-b pathways .
17363372	0	MicroRNA-21	0,11	tropomyosin_1	46,59	MicroRNA-21	tropomyosin 1	406991	7168	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-21 targets the tumor_suppressor gene tropomyosin_1 -LRB- TPM1 -RRB- .
21044961	0	MicroRNA-210	0,12	fibroblast_growth_factor_receptor-like_1	67,107	MicroRNA-210	fibroblast growth factor receptor-like 1	406992	53834	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast_growth_factor_receptor-like_1 -LRB- FGFRL1 -RRB- .
24980667	0	MicroRNA-210	0,12	potassium_channel_modulatory_factor_1	59,96	MicroRNA-210	potassium channel modulatory factor 1	406992	56888	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	MicroRNA-210 contributes to preeclampsia by downregulating potassium_channel_modulatory_factor_1 .
22235338	0	MicroRNA-211	0,12	CHD5	114,118	MicroRNA-211	CHD5	406993	26038	Gene	Gene	expression|amod|START_ENTITY promotes|nsubj|expression promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-211 expression promotes colorectal_cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5 .
26722446	0	MicroRNA-214	0,12	PCBP2	21,26	MicroRNA-214	PCBP2	406996	5094	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-214 targets PCBP2 to suppress the proliferation and growth of glioma cells .
22308024	0	MicroRNA-217	0,12	SIRT1	89,94	MicroRNA-217	SIRT1	387213(Tax:10090)	93759(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1 .
26610210	0	MicroRNA-22	0,11	MMP14	89,94	MicroRNA-22	MMP14	407004	4323	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-22 inhibits tumor growth and metastasis in gastric_cancer by directly targeting MMP14 and Snail .
25586265	0	MicroRNA-221	0,12	Apaf-1	94,100	MicroRNA-221	Apaf-1	407006	317	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|END_ENTITY	MicroRNA-221 accelerates the proliferation of laryngeal_cancer cell line Hep-2 by suppressing Apaf-1 .
26482612	0	MicroRNA-221	0,12	PTEN	21,25	MicroRNA-221	PTEN	407006	5728	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-221 targets PTEN to reduce the sensitivity of cervical_cancer cells to gefitinib through the PI3K/Akt signaling pathway .
22569260	0	MicroRNA-223	0,12	FOXO1	23,28	MicroRNA-223	FOXO1	407008	2308	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	MicroRNA-223 regulates FOXO1 expression and cell proliferation .
26505221	0	MicroRNA-223	0,12	FOXO3	111,116	MicroRNA-223	FOXO3	407008	2309	Gene	Gene	Upregulated|nsubjpass|START_ENTITY Upregulated|nmod|END_ENTITY	MicroRNA-223 Is Upregulated in Active Tuberculosis Patients and Inhibits Apoptosis of Macrophages by Targeting FOXO3 .
23922662	0	MicroRNA-224	0,12	SMAD_family_member_4	21,41	MicroRNA-224	SMAD family member 4	407009	4089	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-224 targets SMAD_family_member_4 to promote cell proliferation and negatively influence patient survival .
24382668	0	MicroRNA-224	0,12	TRIB1	77,82	MicroRNA-224	TRIB1	407009	10221	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|downregulating downregulating|dobj|END_ENTITY	MicroRNA-224 inhibits progression of human prostate_cancer by downregulating TRIB1 .
26160225	0	MicroRNA-23a	0,12	PTEN	53,57	MicroRNA-23a	PTEN	407010	5728	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma .
26153982	0	MicroRNA-23b	0,12	Smad3	97,102	MicroRNA-23b	Smad3	100314002(Tax:10116)	25631(Tax:10116)	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|END_ENTITY	MicroRNA-23b Inhibits the Proliferation and Migration of Heat-Denatured Fibroblasts by Targeting Smad3 .
22710126	0	MicroRNA-23b	0,12	peroxiredoxin_III	27,44	MicroRNA-23b	peroxiredoxin III	407011	10935	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	MicroRNA-23b downregulates peroxiredoxin_III in human prostate_cancer .
23884416	0	MicroRNA-24	0,11	NDST1	63,68	MicroRNA-24	NDST1	407012	3340	Gene	Gene	suppression|amod|START_ENTITY suppression|appos|END_ENTITY	MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase -1 -LRB- NDST1 -RRB- reduces endothelial cell responsiveness to vascular_endothelial_growth_factor_A -LRB- VEGFA -RRB- .
22733138	0	MicroRNA-24	0,11	XIAP	22,26	MicroRNA-24	XIAP	407012	331	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells .
26631964	0	MicroRNA-24	0,11	serotonin_reuptake_transporter	21,51	MicroRNA-24	serotonin reuptake transporter	407012	6532	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	MicroRNA-24 inhibits serotonin_reuptake_transporter expression and aggravates irritable_bowel_syndrome .
26437444	0	MicroRNA-25	105,116	SOCS4	84,89	MicroRNA-25	SOCS4	407014	122809	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Interleukin-23 Facilitates Thyroid_Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25 .
23435373	0	MicroRNA-25	0,11	Smad7	83,88	MicroRNA-25	Smad7	407014	4092	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	MicroRNA-25 functions as a potential tumor suppressor in colon_cancer by targeting Smad7 .
25550809	0	MicroRNA-25	0,11	cyclin_E2	85,94	MicroRNA-25	cyclin E2	407014	9134	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MicroRNA-25 regulates small_cell_lung_cancer cell development and cell cycle through cyclin_E2 .
24890815	0	MicroRNA-26b	0,12	USP9X	97,102	MicroRNA-26b	USP9X	407017	8239	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-26b inhibits epithelial-mesenchymal_transition in hepatocellular_carcinoma by targeting USP9X .
24133204	0	MicroRNA-27	0,11	prohibitin	29,39	MicroRNA-27	prohibitin	407018	5245	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-27 -LRB- miR-27 -RRB- targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells .
25012245	0	MicroRNA-27b	0,12	Sp1	72,75	MicroRNA-27b	Sp1	407019	6667	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	MicroRNA-27b suppresses growth and invasion of NSCLC cells by targeting Sp1 .
25663918	0	MicroRNA-27b	0,12	Spry2	22,27	MicroRNA-27b	Spry2	407019	10253	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	MicroRNA-27b inhibits Spry2 expression and promotes cell invasion in glioma U251 cells .
20131257	0	MicroRNA-27b	0,12	matrix_metalloproteinase_13	41,68	MicroRNA-27b	matrix metalloproteinase 13	407019	4322	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MicroRNA-27b regulates the expression of matrix_metalloproteinase_13 in human osteoarthritis chondrocytes .
26822433	0	MicroRNA-29	0,11	PTEN	103,107	MicroRNA-29	PTEN	407021	5728	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal_pigment_epithelial cells through PTEN .
25665754	0	MicroRNA-29A	0,12	PTEN	13,17	MicroRNA-29A	PTEN	100314230(Tax:10116)	50557(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|END_ENTITY	MicroRNA-29A / PTEN pathway modulates neurite outgrowth in PC12 cells .
24210072	0	MicroRNA-29a	0,12	MMP2	25,29	MicroRNA-29a	MMP2	407021	4313	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	MicroRNA-29a upregulates MMP2 in oral squamous_cell_carcinoma to promote cancer invasion and anti-apoptosis .
25551793	0	MicroRNA-301a	0,13	TGFBR2	59,65	MicroRNA-301a	TGFBR2	407027	7048	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal_cancer .
23450709	0	MicroRNA-30a	0,12	Lyn	116,119	MicroRNA-30a	Lyn	407029	4067	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|interaction interaction|nmod|END_ENTITY	MicroRNA-30a promotes B cell hyperactivity in patients with systemic_lupus_erythematosus by direct interaction with Lyn .
25630974	0	MicroRNA-30d	0,12	HOXA11	40,46	MicroRNA-30d	HOXA11	407033	3207	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	MicroRNA-30d and microRNA-181a regulate HOXA11 expression in the uterosacral ligaments and are overexpressed in pelvic organ prolapse .
22733810	0	MicroRNA-30d	0,12	MafA	50,54	MicroRNA-30d	MafA	387228(Tax:10090)	378435(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated_protein_4_kinase_4 -LRB- MAP4K4 -RRB- in pancreatic b-cells .
24752710	0	MicroRNA-31	0,11	BRAF	38,42	MicroRNA-31	BRAF	407035	673	Gene	Gene	expression|amod|START_ENTITY expression|acl|END_ENTITY	MicroRNA-31 expression in relation to BRAF mutation , CpG island methylation and colorectal continuum in serrated lesions .
26978146	0	MicroRNA-31	19,30	CD4	34,37	MicroRNA-31	CD4	407035	920	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Down-regulation of MicroRNA-31 in CD4 + T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing .
22532441	0	MicroRNA-31	0,11	FIH-1	20,25	MicroRNA-31	FIH-1	407035	55662	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism .
23617834	0	MicroRNA-32	0,11	phosphatase_and_tensin_homologue	31,63	MicroRNA-32	phosphatase and tensin homologue	407036	5728	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-32 -LRB- miR-32 -RRB- regulates phosphatase_and_tensin_homologue -LRB- PTEN -RRB- expression and promotes growth , migration , and invasion in colorectal_carcinoma cells .
25901521	0	MicroRNA-320	0,12	E2F1	64,68	MicroRNA-320	E2F1	407037	1869	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1 .
19270061	0	MicroRNA-328	0,12	breast_cancer_resistance_protein	52,84	MicroRNA-328	breast cancer resistance protein	442901	9429	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MicroRNA-328 negatively regulates the expression of breast_cancer_resistance_protein -LRB- BCRP/ABCG2 -RRB- in human cancer cells .
23625920	0	MicroRNA-33a	0,12	thyroid_transcription_factor_1	86,116	MicroRNA-33a	thyroid transcription factor 1	407039	7080	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	MicroRNA-33a mediates the regulation of high_mobility_group_AT-hook_2 gene -LRB- HMGA2 -RRB- by thyroid_transcription_factor_1 -LRB- TTF-1 / NKX2-1 -RRB- .
25546234	0	MicroRNA-33b	0,12	c-Myc	60,65	MicroRNA-33b	c-Myc	693120	4609	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|nmod|END_ENTITY	MicroRNA-33b Suppresses Migration and Invasion by Targeting c-Myc in Osteosarcoma Cells .
26198939	0	MicroRNA-34a	1,13	CD44	48,52	MicroRNA-34a	CD44	407040	960	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	-LSB- MicroRNA-34a regulates cell cycle by targeting CD44 in human bladder_carcinoma cells -RSB- .
26198939	0	MicroRNA-34a	1,13	CD44	48,52	MicroRNA-34a	CD44	407040	960	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	-LSB- MicroRNA-34a regulates cell cycle by targeting CD44 in human bladder_carcinoma cells -RSB- .
26103003	0	MicroRNA-34a	0,12	FMNL2	21,26	MicroRNA-34a	FMNL2	407040	114793	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-34a targets FMNL2 and E2F5 and suppresses the progression of colorectal_cancer .
24792364	0	MicroRNA-34a	0,12	Forkhead_box_j2	21,36	MicroRNA-34a	Forkhead box j2	407040	55810	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-34a targets Forkhead_box_j2 to modulate differentiation of endothelial progenitor cells in response to shear stress .
26335888	0	MicroRNA-34a	0,12	MYC	67,70	MicroRNA-34a	MYC	407040	4609	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-34a inhibits human trophoblast cell invasion by targeting MYC .
22684560	0	MicroRNA-34a	0,12	Notch1	75,81	MicroRNA-34a	Notch1	407040	4851	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	MicroRNA-34a inhibits human brain_glioma cell growth by down-regulation of Notch1 .
23085450	0	MicroRNA-34a	0,12	Notch1	90,96	MicroRNA-34a	Notch1	407040	4851	Gene	Gene	modulates|nsubj|START_ENTITY modulates|xcomp|adriamycin adriamycin|nmod|END_ENTITY	MicroRNA-34a modulates chemosensitivity of breast_cancer cells to adriamycin by targeting Notch1 .
25783790	0	MicroRNA-34a	0,12	Notch1	91,97	MicroRNA-34a	Notch1	407040	4851	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|ccomp|stem stem|advcl|downregulating downregulating|dobj|END_ENTITY	MicroRNA-34a suppresses the breast_cancer stem cell-like characteristics by downregulating Notch1 pathway .
22364258	0	MicroRNA-34a	0,12	SIRT1	56,61	MicroRNA-34a	SIRT1	407040	23411	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary_artery_disease : effect of statins on SIRT1 and microRNA-34a expression .
21743299	0	MicroRNA-34a	0,12	notch1	21,27	MicroRNA-34a	notch1	407040	4851	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme .
20386864	0	MicroRNA-34a	0,12	p53	28,31	MicroRNA-34a	p53	723848(Tax:10090)	22060(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival .
24623309	0	MicroRNA-34a	0,12	p53	32,35	MicroRNA-34a	p53	723848(Tax:10090)	22060(Tax:10090)	Gene	Gene	dispensable|nsubj|START_ENTITY dispensable|nmod|function function|compound|END_ENTITY	MicroRNA-34a is dispensable for p53 function as teratogenesis inducer .
17823410	0	MicroRNA-34b	0,12	p53	45,48	MicroRNA-34b	p53	407041	7157	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth .
24936138	0	MicroRNA-365	0,12	cyclin_D1	82,91	MicroRNA-365	cyclin D1	100314252(Tax:10116)	58919(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MicroRNA-365 inhibits vascular smooth muscle cell proliferation through targeting cyclin_D1 .
24936138	0	MicroRNA-365	0,12	cyclin_D1	82,91	MicroRNA-365	cyclin D1	100314252(Tax:10116)	58919(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	MicroRNA-365 inhibits vascular smooth muscle cell proliferation through targeting cyclin_D1 .
25976502	0	MicroRNA-370	0,12	TRAF4	95,100	MicroRNA-370	TRAF4	442915	9618	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|downregulating downregulating|dobj|END_ENTITY	MicroRNA-370 inhibits the progression of non-small_cell_lung_cancer by downregulating oncogene TRAF4 .
23178988	0	MicroRNA-375	0,12	cadherin-7	33,43	MicroRNA-375	cadherin-7	494324	1005	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	MicroRNA-375 , a new regulator of cadherin-7 , suppresses the migration of chondrogenic progenitors .
26782975	0	MicroRNA-378	0,12	BMP4	60,64	MicroRNA-378	BMP4	723889(Tax:10090)	12159(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-378 promotes myogenic differentiation by targeting BMP4 .
25450356	0	MicroRNA-383	0,12	CCND1	110,115	MicroRNA-383	CCND1	494332	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-383 inhibits anchorage-independent growth and induces cell cycle arrest of glioma cells by targeting CCND1 .
24675898	0	MicroRNA-424	0,12	c-Myb	110,115	MicroRNA-424	c-Myb	494336	4602	Gene	Gene	down-regulated|nsubjpass|START_ENTITY down-regulated|nmod|END_ENTITY	MicroRNA-424 is down-regulated in hepatocellular carcinoma and suppresses cell migration and invasion through c-Myb .
27058905	0	MicroRNA-452	0,12	sox7	80,84	MicroRNA-452	sox7	574412	83595	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	MicroRNA-452 promotes stem-like cells of hepatocellular_carcinoma by inhibiting sox7 involving wnt/b-catenin signaling pathway .
22963823	0	MicroRNA-467b	0,13	LPL	22,25	MicroRNA-467b	LPL	735257(Tax:10090)	16956(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MicroRNA-467b targets LPL gene in RAW 264.7 macrophages and attenuates lipid accumulation and proinflammatory cytokine secretion .
25253996	0	MicroRNA-492	0,12	PTEN	80,84	MicroRNA-492	PTEN	574449	5728	Gene	Gene	expression|amod|START_ENTITY promotes|nsubj|expression promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-492 expression promotes the progression of hepatic_cancer by targeting PTEN .
26198045	0	MicroRNA-495	0,12	FOXC1	27,32	MicroRNA-495	FOXC1	574453	2296	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial_cancer .
26198045	0	MicroRNA-495	0,12	FOXC1	27,32	MicroRNA-495	FOXC1	574453	2296	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	MicroRNA-495 downregulates FOXC1 expression to suppress cell growth and migration in endometrial_cancer .
25846731	0	MicroRNA-506	0,12	Yap1	86,90	MicroRNA-506	Yap1	574511	10413	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-506 inhibits gastric_cancer proliferation and invasion by directly targeting Yap1 .
25143867	0	MicroRNA-570-3p	0,15	HuR	26,29	MicroRNA-570-3p	HuR	100847081	1994	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-570-3p regulates HuR and cytokine expression in airway epithelial cells .
24913918	0	MicroRNA-581	0,12	Dicer	80,85	MicroRNA-581	Dicer	693166	23405	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-581 promotes hepatitis_B virus surface antigen expression by targeting Dicer and EDEM1 .
26499912	0	MicroRNA-616	0,12	PTEN	104,108	MicroRNA-616	PTEN	693201	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-616 promotes the migration , invasion and epithelial-mesenchymal transition of HCC by targeting PTEN .
20381459	0	MicroRNA-650	0,12	ING4	21,25	MicroRNA-650	ING4	723778	51147	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	MicroRNA-650 targets ING4 to promote gastric_cancer tumorigenicity .
25281924	0	MicroRNA-874	0,12	CDK9	99,103	MicroRNA-874	CDK9	100126343	1025	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast_cancer by targeting CDK9 .
25695884	0	MicroRNA-93	0,11	CDKN1A	77,83	MicroRNA-93	CDKN1A	407051	1026	Gene	Gene	Proliferation|compound|START_ENTITY Proliferation|dep|END_ENTITY	MicroRNA-93 Promotes Ovarian Granulosa Cells Proliferation Through Targeting CDKN1A in Polycystic_Ovarian_Syndrome .
24642374	0	MicroRNA-93	0,11	IRAK4	104,109	MicroRNA-93	IRAK4	723968(Tax:10090)	266632(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-93 inhibits inflammatory cytokine production in LPS-stimulated murine macrophages by targeting IRAK4 .
23492819	0	MicroRNA-93	0,11	NRF2	22,26	MicroRNA-93	NRF2	407051	4780	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MicroRNA-93 regulates NRF2 expression and is associated with breast_carcinogenesis .
25309979	0	MicroRNA-93	0,11	cyclin_G2	22,31	MicroRNA-93	cyclin G2	407051	901	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA-93 regulates cyclin_G2 expression and plays an oncogenic role in laryngeal_squamous_cell_carcinoma .
21654638	0	MicroRNA122	0,11	a-fetoprotein	34,47	MicroRNA122	a-fetoprotein	406906	174	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	MicroRNA122 is a key regulator of a-fetoprotein expression and influences the aggressiveness of hepatocellular_carcinoma .
20332243	0	MicroRNA145	0,11	BNIP3	20,25	MicroRNA145	BNIP3	406937	664	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	MicroRNA145 targets BNIP3 and suppresses prostate_cancer progression .
26552593	0	MicroRNA367	0,11	IRAK4	85,90	MicroRNA367	IRAK4	723911(Tax:10090)	266632(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral_hemorrhage .
26090465	0	MicroRNA3686	4,16	Polo-Like_Kinase_1	93,111	MicroRNA3686	Polo-Like Kinase 1	100500839	5347	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|advcl|Targeting Targeting|dobj|END_ENTITY	The MicroRNA3686 Inhibits the Proliferation of Pancreas_Carcinoma Cell Line by Targeting the Polo-Like_Kinase_1 .
26818658	0	MicroRNA_429	0,12	mucin	23,28	MicroRNA 429	mucin	723865(Tax:10090)	100508689	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MicroRNA_429 regulates mucin gene expression and secretion in murine model of colitis .
21827835	0	MicroRNA_let-7e	0,15	caspase-3	44,53	MicroRNA let-7e	caspase-3	100313991(Tax:10116)	25402(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	MicroRNA_let-7e regulates the expression of caspase-3 during apoptosis of PC12 cells following anoxia/reoxygenation injury .
19267414	0	Microcephalin	26,39	MCPH1	41,46	Microcephalin	MCPH1	79648	79648	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The c. 940G variant of the Microcephalin -LRB- MCPH1 -RRB- gene is not associated with microcephaly or mental_retardation .
15233806	0	Microfibril-associated_glycoprotein-1	0,37	tropoelastin	49,61	Microfibril-associated glycoprotein-1	tropoelastin	4237	2006	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Microfibril-associated_glycoprotein-1 binding to tropoelastin : multiple binding sites and the role of divalent cations .
15381155	0	Microfibril-associated_glycoprotein-1	0,37	tropoelastin	74,86	Microfibril-associated glycoprotein-1	tropoelastin	4237	2006	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|deposition deposition|compound|END_ENTITY	Microfibril-associated_glycoprotein-1 and fibrillin-2 are associated with tropoelastin deposition in vitro .
25584612	0	Microphthalmia-Associated_Transcription_Factor	144,190	MITF	192,196	Microphthalmia-Associated Transcription Factor	MITF	17342(Tax:10090)	17342(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Hair Dyes Resorcinol and Lawsone Reduce Production of Melanin in Melanoma Cells by Tyrosinase Activity Inhibition and Decreasing Tyrosinase and Microphthalmia-Associated_Transcription_Factor -LRB- MITF -RRB- Expression .
16822840	0	Microphthalmia-associated_transcription_factor	0,46	14-3-3	65,71	Microphthalmia-associated transcription factor	14-3-3	4286	10971	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Microphthalmia-associated_transcription_factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors .
12032083	0	Microphthalmia-associated_transcription_factor	0,46	LEF-1	62,67	Microphthalmia-associated transcription factor	LEF-1	4286	51176	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Microphthalmia-associated_transcription_factor interacts with LEF-1 , a mediator of Wnt signaling .
22115973	0	Microphthalmia-associated_transcription_factor	0,46	PEDF	60,64	Microphthalmia-associated transcription factor	PEDF	4286	5176	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Microphthalmia-associated_transcription_factor acts through PEDF to regulate RPE cell migration .
18281284	0	Microphthalmia-associated_transcription_factor	0,46	RAB27A	57,63	Microphthalmia-associated transcription factor	RAB27A	4286	5873	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Microphthalmia-associated_transcription_factor regulates RAB27A gene expression and controls melanosome transport .
26876013	0	Microphthalmia-associated_transcription_factor	0,46	Rlbp1	80,85	Microphthalmia-associated transcription factor	Rlbp1	17342(Tax:10090)	19771(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Microphthalmia-associated_transcription_factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal_pigment_epithelium .
7969144	0	Microphthalmia-associated_transcription_factor	0,46	tyrosinase	113,123	Microphthalmia-associated transcription factor	tyrosinase	4286	7299	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Microphthalmia-associated_transcription_factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene .
18313864	0	Microphthalmia_transcription_factor	0,35	GPNMB	92,97	Microphthalmia transcription factor	GPNMB	17342(Tax:10090)	93695(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Microphthalmia_transcription_factor regulates the expression of the novel osteoclast factor GPNMB .
17564249	0	Microsomal_epoxide_hydrolase	0,28	COPD	52,56	Microsomal epoxide hydrolase	COPD	2052	260431	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Microsomal_epoxide_hydrolase is not associated with COPD in a community-based sample .
26849376	0	Microspherule_Protein	20,41	MSP58	43,48	Microspherule Protein	MSP58	10445	10445	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of 58-kD Microspherule_Protein -LRB- MSP58 -RRB- is Highly Correlated with PET Imaging of Tumor Malignancy and Cell Proliferation in Glioma Patients .
22609355	0	Microspherule_protein_2	0,23	ASK1	40,44	Microspherule protein 2	ASK1	10445	4217	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Microspherule_protein_2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation .
15450909	0	Microtubule-associated_protein	0,30	MAP2	31,35	Microtubule-associated protein	MAP2	51115	4133	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Microtubule-associated_protein MAP2 expression in olfactory bulb in schizophrenia .
17521179	0	Microtubule-associated_protein_1B	0,33	glyceraldehyde-3-phosphate_dehydrogenase	40,80	Microtubule-associated protein 1B	glyceraldehyde-3-phosphate dehydrogenase	29456(Tax:10116)	24383(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Microtubule-associated_protein_1B binds glyceraldehyde-3-phosphate_dehydrogenase .
11739659	0	Microtubule-associated_protein_1B	0,33	glycogen_synthase_kinase_3beta	53,83	Microtubule-associated protein 1B	glycogen synthase kinase 3beta	29456(Tax:10116)	84027(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Microtubule-associated_protein_1B phosphorylation by glycogen_synthase_kinase_3beta is induced during PC12 cell differentiation .
18075266	0	Microtubule-associated_protein_1B	0,33	tubulin_tyrosine_ligase	51,74	Microtubule-associated protein 1B	tubulin tyrosine ligase	4131	150465	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Microtubule-associated_protein_1B interaction with tubulin_tyrosine_ligase contributes to the control of microtubule tyrosination .
15070402	0	Mid1	119,123	Mig12	0,5	Mid1	Mig12	4281	58526	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Mig12 , a novel Opitz_syndrome gene product partner , is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules .
26748699	0	Mid2	65,69	Astrin	85,91	Mid2	Astrin	11043	10615	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division .
8537330	0	Midkine	0,7	MK	9,11	Midkine	MK	17242(Tax:10090)	17242(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Midkine -LRB- MK -RRB- expression in extraembryonic tissues , amniotic fluid , and cerebrospinal fluid during mouse embryogenesis .
23243020	0	Midkine	0,7	Notch2	39,45	Midkine	Notch2	17242(Tax:10090)	4853	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Midkine promotes neuroblastoma through Notch2 signaling .
18392135	0	Midkine	18,25	VEGF	38,42	Midkine	VEGF	4192	7422	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	The growth factor Midkine antagonizes VEGF signaling in vitro and in vivo .
11597123	0	Midkine	0,7	laminin_binding_protein_precursor	24,57	Midkine	laminin binding protein precursor	17242(Tax:10090)	16803(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Midkine binds to 37-kDa laminin_binding_protein_precursor , leading to nuclear transport of the complex .
15985215	0	Midkine	0,7	pleiotrophin	18,30	Midkine	pleiotrophin	17242(Tax:10090)	19242(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Midkine regulates pleiotrophin organ-specific gene expression : evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family .
12792744	0	Mig	18,21	CXCL9	23,28	Mig	CXCL9	17329(Tax:10090)	17329(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the Mig -LRB- CXCL9 -RRB- gene in murine lung_carcinoma cells generated angiogenesis-independent antitumor effects .
11600578	0	Mig	78,81	CXCR3	94,99	Mig	CXCR3	4283	2833	Gene	Gene	START_ENTITY|dobj|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Thyrocytes from autoimmune_thyroid_disorders produce the chemokines IP-10 and Mig and attract CXCR3 + lymphocytes .
22266086	0	Mig	104,107	Mig	49,52	Mig	Mig	17329(Tax:10090)	4283	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and purification of recombinant human Mig in Escherichia_coli and its comparison with murine Mig .
22266086	0	Mig	49,52	Mig	104,107	Mig	Mig	4283	17329(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and purification of recombinant human Mig in Escherichia_coli and its comparison with murine Mig .
11160225	0	Mig	14,17	monokine_induced_by_interferon-gamma	19,55	Mig	monokine induced by interferon-gamma	17329(Tax:10090)	17329(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Mig -LRB- monokine_induced_by_interferon-gamma -RRB- is important in T lymphocyte recruitment and host defense following viral_infection_of_the_central_nervous_system .
15070402	0	Mig12	0,5	Mid1	119,123	Mig12	Mid1	58526	4281	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Mig12 , a novel Opitz_syndrome gene product partner , is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules .
12393187	0	Mig1p	51,56	COQ5	15,19	Mig1p	COQ5	852848(Tax:4932)	854930(Tax:4932)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The yeast gene COQ5 is differentially regulated by Mig1p , Rtg3p and Hap2p .
26760771	0	Mig6	8,12	Gene_33	0,7	Mig6	Gene 33	54206	54206	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	Gene_33 / Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells .
20600851	0	Migration_Stimulating_Factor	0,28	AKT	79,82	Migration Stimulating Factor	AKT	2335	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	Migration_Stimulating_Factor -LRB- MSF -RRB- promotes fibroblast migration by inhibiting AKT .
25937984	0	Milk_Protein	55,67	Alpha_S1-Casein	39,54	Milk Protein	Alpha S1-Casein	281099(Tax:9913)	282208(Tax:9913)	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Variations in the Regulatory Region of Alpha_S1-Casein Milk_Protein Gene among Tropically Adapted Indian Native -LRB- Bos_Indicus -RRB- Cattle .
18008006	0	Milk_fat_globule-EGF_factor_8	0,29	lactadherin	30,41	Milk fat globule-EGF factor 8	lactadherin	17304(Tax:10090)	17304(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	Milk_fat_globule-EGF_factor_8 / lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium .
10213222	0	Min	135,138	Apc	131,134	Min	Apc	11789(Tax:10090)	11789(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Evaluation of 5-aminosalicylic_acid -LRB- 5-ASA -RRB- for cancer chemoprevention : lack of efficacy against nascent adenomatous_polyps in the Apc -LRB- Min -RRB- mouse .
1541640	0	Min	4,7	multiple_intestinal_neoplasia	9,38	Min	multiple intestinal neoplasia	11789(Tax:10090)	11789(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	The Min -LRB- multiple_intestinal_neoplasia -RRB- mutation : its effect on gut epithelial cell differentiation and interaction with a modifier system .
19686683	0	Mind_bomb	21,30	PAR-1	0,5	Mind bomb	PAR-1	57534	145624	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	PAR-1 phosphorylates Mind_bomb to promote vertebrate neurogenesis .
20876658	0	Mind_the_gap	96,108	Jelly_belly	12,23	Mind the gap	Jelly belly	40970(Tax:7227)	36295(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Anterograde Jelly_belly ligand to Alk receptor signaling at developing synapses is regulated by Mind_the_gap .
15775959	0	Mini_spindles	0,13	XMAP215	19,26	Mini spindles	XMAP215	41952(Tax:7227)	41952(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Mini_spindles , the XMAP215 homologue , suppresses pausing of interphase microtubules in Drosophila .
26712671	0	Minichromosome_maintenance-2	0,28	MCM2	30,34	Minichromosome maintenance-2	MCM2	4171	4171	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Minichromosome_maintenance-2 -LRB- MCM2 -RRB- expression differentiates oral_squamous_cell_carcinoma from pre-cancerous lesions .
18373176	0	Minichromosome_maintenance_2	0,28	MCM2	30,34	Minichromosome maintenance 2	MCM2	4171	4171	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Minichromosome_maintenance_2 -LRB- MCM2 -RRB- immunoreactivity in stage III human gastric_carcinoma : clinicopathological significance .
19726677	0	Mint3	0,5	HIF-1	59,64	Mint3	HIF-1	9546	3091	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Mint3 enhances the activity of hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- in macrophages by suppressing the activity of factor_inhibiting_HIF-1 .
24969300	0	Mir-126	0,7	PI3KR2_and_Crk	85,99	Mir-126	PI3KR2 and Crk	406913	1398	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Mir-126 inhibits growth of SGC-7901 cells by synergistically targeting the oncogenes PI3KR2_and_Crk , and the tumor suppressor PLK2 .
25155037	0	Mir-155	0,7	LKB1	91,95	Mir-155	LKB1	406947	6794	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	Mir-155 promotes cervical_cancer cell proliferation through suppression of its target gene LKB1 .
25058005	0	Mir-21	14,20	PTEN	21,25	Mir-21	PTEN	406991	5728	Gene	Gene	Alteration|nmod|START_ENTITY Alteration|parataxis|modulates modulates|nsubj|expression expression|compound|END_ENTITY	Alteration in Mir-21 / PTEN expression modulates gefitinib resistance in non-small_cell_lung_cancer .
26111641	0	Mir-326	20,27	Adam17	0,6	Mir-326	Adam17	442900	6868	Gene	Gene	Target|nmod|START_ENTITY END_ENTITY|appos|Target	Adam17 , a Target of Mir-326 , Promotes Emt-Induced Cells Invasion in Lung_Adenocarcinoma .
26129673	0	Mir125a	0,7	Uvrag	26,31	Mir125a	Uvrag	387235(Tax:10090)	78610(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	Mir125a and Mir351 target Uvrag and modulate autophagy .
24578347	0	Mir302a	68,75	cyclin_D1	29,38	Mir302a	cyclin D1	723920(Tax:10090)	12443(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|amod|END_ENTITY	GCNF-dependent activation of cyclin_D1 expression via repression of Mir302a during ESC differentiation .
9403694	0	Miranda	0,7	Prospero	16,24	Miranda	Prospero	42379(Tax:7227)	41363(Tax:7227)	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|END_ENTITY	Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions .
21353556	0	Mis12	32,37	Cenp-C	18,24	Mis12	Cenp-C	79003	1060	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore .
10021364	0	Misshapen	74,83	TNF-receptor-associated_factor	13,43	Misshapen	TNF-receptor-associated factor	44030(Tax:7227)	33638(Tax:7227)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	A Drosophila TNF-receptor-associated_factor -LRB- TRAF -RRB- binds the ste20 kinase Misshapen and activates Jun_kinase .
18762186	0	Mist1	0,5	WAF1	70,74	Mist1	WAF1	17341(Tax:10090)	12575(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Mist1 regulates pancreatic acinar cell proliferation through p21_CIP1 / WAF1 .
21925392	0	Mistral	18,25	Hoxa6	36,41	Mistral	Hoxa6	100736249	15403(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin .
12086670	0	Mitf	51,55	Bcl2	0,4	Mitf	Bcl2	17342(Tax:10090)	12043(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability .
19553286	0	Mitf	109,113	Beta-catenin	0,12	Mitf	Beta-catenin	17342(Tax:10090)	12387(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY controls|advcl|regulating controls|nsubj|END_ENTITY	Beta-catenin controls differentiation of the retinal_pigment_epithelium in the mouse optic cup by regulating Mitf and Otx2 expression .
15576400	0	Mitf	20,24	Chx10	0,5	Mitf	Chx10	4286	338917	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity .
17182868	0	Mitf	0,4	Dia1	19,23	Mitf	Dia1	4286	1729	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Mitf regulation of Dia1 controls melanoma proliferation and invasiveness .
25152440	0	Mitf	0,4	NFATc1	48,54	Mitf	NFATc1	17342(Tax:10090)	18018(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY	Mitf regulates osteoclastogenesis by modulating NFATc1 activity .
20357005	0	Mitf	0,4	RANKL	18,23	Mitf	RANKL	4286	8600	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Mitf induction by RANKL is critical for osteoclastogenesis .
15716956	0	Mitf	0,4	Rb1	21,24	Mitf	Rb1	4286	5925	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression .
15250937	0	Mitf	135,139	Sox10	22,27	Mitf	Sox10	17342(Tax:10090)	20665(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Sox10 with the promoter of murine Dopachrome_Tautomerase -LRB- Dct -RRB- and synergistic activation of Dct expression with Mitf .
26761346	0	Mitf	11,15	V-ATPase	30,38	Mitf	V-ATPase	3885647(Tax:7227)	40679(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway .
19515996	0	Mitf	15,19	Zeb1	0,4	Mitf	Zeb1	17342(Tax:10090)	21417(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	Zeb1 represses Mitf and regulates pigment synthesis , cell proliferation , and epithelial morphology .
17000761	0	Mitf	51,55	beta-catenin	71,83	Mitf	beta-catenin	4286	1499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression .
16455654	0	Mitf	33,37	c-Met	0,5	Mitf	c-Met	4286	4233	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	c-Met expression is regulated by Mitf in the melanocyte lineage .
17266927	0	Mitf	45,49	microphthalmia_transcription_factor	8,43	Mitf	microphthalmia transcription factor	17342(Tax:10090)	17342(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of microphthalmia_transcription_factor -LRB- Mitf -RRB- in melanoma differentiation .
18028952	0	Mitf	50,54	microphthalmia_transcription_factor	13,48	Mitf	microphthalmia transcription factor	4286	4286	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of microphthalmia_transcription_factor -LRB- Mitf -RRB- by forskolin and stimulation of melanin release in UISO-Mel-6 cells .
26092939	0	Mitf	0,4	v-ATPase	34,42	Mitf	v-ATPase	3885647(Tax:7227)	40679(Tax:7227)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Mitf is a master regulator of the v-ATPase forming an Mitf/v-ATPase/TORC1 control module for cellular homeostasis .
25764156	0	Mitochondrial_Calcium_Uniporter	73,104	MiR-25	0,6	Mitochondrial Calcium Uniporter	MiR-25	90550	407014	Gene	Gene	Targeting|dobj|START_ENTITY Damage|advcl|Targeting Damage|nsubj|Cardiomyocytes Cardiomyocytes|compound|END_ENTITY	MiR-25 Protects Cardiomyocytes against Oxidative Damage by Targeting the Mitochondrial_Calcium_Uniporter .
25816318	0	Mitochondrial_Trifunctional_Protein	69,104	NS5	50,53	Mitochondrial Trifunctional Protein	NS5	4547	5894	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	Japanese_Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial_Trifunctional_Protein and Impairs Fatty Acid b-Oxidation .
8516360	0	Mitochondrial_aldehyde_dehydrogenase	0,36	ALDH2	38,43	Mitochondrial aldehyde dehydrogenase	ALDH2	29539(Tax:10116)	29539(Tax:10116)	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Mitochondrial_aldehyde_dehydrogenase -LRB- ALDH2 -RRB- polymorphism in AA and ANA rats : lack of genotype and phenotype line differences .
16024796	0	Mitochondrial_ribosomal_protein_L41	0,35	p53	79,82	Mitochondrial ribosomal protein L41	p53	107733(Tax:10090)	22060(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Mitochondrial_ribosomal_protein_L41 suppresses cell growth in association with p53 and p27Kip1 .
22098591	0	Mitochondrial_transcription_factor_A	0,36	BCL2L1	47,53	Mitochondrial transcription factor A	BCL2L1	7019	598	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Mitochondrial_transcription_factor_A regulates BCL2L1 gene expression and is a prognostic factor in serous ovarian_cancer .
14528910	0	Mitofilin	100,109	Nit_protein_2	44,57	Mitofilin	Nit protein 2	10989	56954	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Deranged hypothetical proteins Rik protein , Nit_protein_2 and mitochondrial_inner_membrane_protein , Mitofilin , in fetal Down syndrome brain .
20804729	0	Mitofusin-2	0,11	p53	40,43	Mitofusin-2	p53	9927	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Mitofusin-2 is a novel direct target of p53 .
19690333	0	Mitofusin_2	0,11	mitochondrial_antiviral_signaling	21,54	Mitofusin 2	mitochondrial antiviral signaling	9927	57506	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Mitofusin_2 inhibits mitochondrial_antiviral_signaling .
26065894	0	Mitogen-Inducible_Gene-6	0,24	BRAF	67,71	Mitogen-Inducible Gene-6	BRAF	54206	673	Gene	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	Mitogen-Inducible_Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal_Growth_Factor_Receptor and Thereby Limits Malignant Transformation .
26065894	0	Mitogen-Inducible_Gene-6	0,24	Epidermal_Growth_Factor_Receptor	84,116	Mitogen-Inducible Gene-6	Epidermal Growth Factor Receptor	54206	1956	Gene	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	Mitogen-Inducible_Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal_Growth_Factor_Receptor and Thereby Limits Malignant Transformation .
8398135	0	Mitogen-activated_protein_kinase	0,32	MAP_kinase	34,44	Mitogen-activated protein kinase	MAP kinase	397785(Tax:8355)	397785(Tax:8355)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Mitogen-activated_protein_kinase -LRB- MAP_kinase -RRB- activation in Xenopus oocytes : roles of MPF and protein synthesis .
21454680	0	Mitogen-activated_protein_kinase_kinase_1	0,41	MyoD	60,64	Mitogen-activated protein kinase kinase 1	MyoD	5604	4654	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Mitogen-activated_protein_kinase_kinase_1 -LRB- MEK1 -RRB- stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation .
21926646	0	Mitogen-activated_protein_kinase_kinase_6	0,41	high-mobility_group_box_1	78,103	Mitogen-activated protein kinase kinase 6	high-mobility group box 1	5608	3146	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Mitogen-activated_protein_kinase_kinase_6 mediates mechanical stretch-induced high-mobility_group_box_1 protein expression in pulmonary alveolar epithelial cells .
10212278	0	Mitogen-activated_protein_kinase_phosphatase-1	0,46	MKP-1	48,53	Mitogen-activated protein kinase phosphatase-1	MKP-1	1843	1843	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- expression is induced by low oxygen conditions found in solid tumor microenvironments .
22198506	0	Mitogen-activated_protein_kinase_phosphatase-1	0,46	TNF-a	67,72	Mitogen-activated protein kinase phosphatase-1	TNF-a	19252(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase-1 inhibits myocardial TNF-a expression and improves cardiac function during endotoxemia .
21852324	0	Mitogen-activated_protein_kinase_phosphatase_1	0,46	parathyroid_hormone	118,137	Mitogen-activated protein kinase phosphatase 1	parathyroid hormone	19252(Tax:10090)	19226(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase_1 regulates bone mass , osteoblast gene expression , and responsiveness to parathyroid_hormone .
16778175	0	Mitogen-activated_protein_kinase_phosphatase_2	0,46	p53	80,83	Mitogen-activated protein kinase phosphatase 2	p53	1846	7157	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase_2 : a novel transcription target of p53 in apoptosis .
23223570	0	Mitogen-activated_protein_kinase_phosphatase_2	0,46	vaccinia-related_kinase_1	105,130	Mitogen-activated protein kinase phosphatase 2	vaccinia-related kinase 1	1846	7443	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase_2 regulates histone H3 phosphorylation via interaction with vaccinia-related_kinase_1 .
20044804	0	Mitogen-inducible_gene-6	0,24	epidermal_growth_factor_receptor	52,84	Mitogen-inducible gene-6	epidermal growth factor receptor	54206	1956	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Mitogen-inducible_gene-6 is a negative regulator of epidermal_growth_factor_receptor signaling in hepatocytes and human hepatocellular_carcinoma .
25950605	0	Mitsugumin_53	32,45	Metabolic_Syndrome	10,28	Mitsugumin 53	Metabolic Syndrome	493829	100036290(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Effect|nmod|Expression Effect|nmod|END_ENTITY	Effect of Metabolic_Syndrome on Mitsugumin_53 Expression and Function .
19710696	0	Mixed-lineage-leukemia	0,22	MLL	24,27	Mixed-lineage-leukemia	MLL	214162(Tax:10090)	214162(Tax:10090)	Gene	Gene	fusion|amod|START_ENTITY fusion|appos|END_ENTITY	Mixed-lineage-leukemia -LRB- MLL -RRB- fusion protein collaborates with Ras to induce acute_leukemia through aberrant Hox expression and Raf activation .
16537381	0	Mixed-lineage_kinase_3	0,22	B-Raf	33,38	Mixed-lineage kinase 3	B-Raf	4296	673	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Mixed-lineage_kinase_3 regulates B-Raf through maintenance of the B-Raf/Raf -1 complex and inhibition by the NF2 tumor suppressor protein .
22566623	0	Mixed-lineage_kinase_3	0,22	Pin1	55,59	Mixed-lineage kinase 3	Pin1	4296	5300	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Mixed-lineage_kinase_3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function .
21998658	0	Mixed_Lineage_Leukemia	37,59	MLL	61,64	Mixed Lineage Leukemia	MLL	4297	4297	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	3 ` UTR-mediated gene silencing of the Mixed_Lineage_Leukemia -LRB- MLL -RRB- gene .
19801649	0	Mixed_lineage_kinase	0,20	E47	57,60	Mixed lineage kinase	E47	9175	6929	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Mixed_lineage_kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal_death and survival pathways .
20150185	0	Mixed_lineage_kinase-3	0,22	JNK1	23,27	Mixed lineage kinase-3	JNK1	4296	5599	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|axis axis|compound|END_ENTITY	Mixed_lineage_kinase-3 / JNK1 axis promotes migration of human gastric_cancer cells following gastrin stimulation .
21880738	0	Mixed_lineage_kinase_3	0,22	b-catenin	33,42	Mixed lineage kinase 3	b-catenin	4296	1499	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Mixed_lineage_kinase_3 modulates b-catenin signaling in cancer cells .
23629655	0	Mixed_lineage_leukemia_5	0,24	MLL5	26,30	Mixed lineage leukemia 5	MLL5	55904	55904	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Mixed_lineage_leukemia_5 -LRB- MLL5 -RRB- protein regulates cell cycle progression and E2F1-responsive gene expression via association with host_cell_factor-1 -LRB- HCF-1 -RRB- .
16142238	0	Miz-1	45,50	BCL6	0,4	Miz-1	BCL6	7709	604	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells .
15095404	0	Miz-1	92,97	ECRG1	61,66	Miz-1	ECRG1	9063	339967	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1 .
19001505	0	Miz-1	62,67	Myc	0,3	Miz-1	Myc	7709	4609	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Myc increases self-renewal in neural progenitor cells through Miz-1 .
20697356	0	Miz-1	57,62	Wnt_inhibitory_factor-1	30,53	Miz-1	Wnt inhibitory factor-1	7709	11197	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Wnt_inhibitory_factor-1 by Miz-1 / c-Myc .
20697356	0	Miz-1	57,62	c-Myc	63,68	Miz-1	c-Myc	7709	4609	Gene	Gene	regulation|nmod|START_ENTITY regulation|parataxis|END_ENTITY	Transcriptional regulation of Wnt_inhibitory_factor-1 by Miz-1 / c-Myc .
15580267	0	Miz1	27,31	Akt_and_14-3-3eta	0,17	Miz1	Akt and 14-3-3eta	7709	207;7533	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Akt_and_14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage .
19549844	0	Miz1	29,33	BCL6	0,4	Miz1	BCL6	9063	604	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse_large_B_cell_lymphoma .
16391002	0	Miz1	83,87	Myc	0,3	Miz1	Myc	7709	4609	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1 .
26766587	0	Miz1	28,32	Myc	19,22	Miz1	Myc	7709	4609	Gene	Gene	Identity|compound|START_ENTITY Interaction|nmod|Identity Interaction|nmod|END_ENTITY	The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity .
22509363	0	Miz1	0,4	cdkn1a	32,38	Miz1	cdkn1a	7709	1026	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Miz1 is a critical repressor of cdkn1a during skin tumorigenesis .
19888449	0	Mkk4	36,40	JNK	93,96	Mkk4	JNK	41020(Tax:7227)	44801(Tax:7227)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK .
19303298	0	Mklp2	70,75	Cdk1	0,4	Mklp2	Cdk1	10112	983	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex .
17164422	0	Mkp3	7,11	ERK	64,67	Mkp3	ERK	67603(Tax:10090)	26413(Tax:10090)	Gene	Gene	Dusp6|appos|START_ENTITY regulator|nsubj|Dusp6 regulator|nmod|END_ENTITY	Dusp6 -LRB- Mkp3 -RRB- is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development .
15572144	0	Mkp3	0,4	Fgf8	41,45	Mkp3	Fgf8	1848	2253	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|END_ENTITY	Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer .
12658361	0	Mlc1	39,43	Wkl1	45,49	Mlc1	Wkl1	170790(Tax:10090)	170790(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The genomic organization of the murine Mlc1 -LRB- Wkl1 , KIAA0027 -RRB- gene .
8355600	0	Mlc1	96,100	myosin_alkali_light-chain	69,94	Mlc1	myosin alkali light-chain	43323(Tax:7227)	43323(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Conservation of alternative splicing and genomic organization of the myosin_alkali_light-chain -LRB- Mlc1 -RRB- gene among Drosophila species .
14760383	0	Mlh1	88,92	Fhit	0,4	Mlh1	Fhit	4292	2272	Gene	Gene	expression|amod|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|amod|END_ENTITY	Fhit expression in human gastric_adenomas and intramucosal_carcinomas : correlation with Mlh1 expression and gastric phenotype .
12743174	0	Mlh1	0,4	Msh2	74,78	Mlh1	Msh2	17350(Tax:10090)	17685(Tax:10090)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|recombination recombination|nmod|END_ENTITY	Mlh1 can function in antibody class switch recombination independently of Msh2 .
12042306	0	Mlh1p	188,193	Ntg2p	0,5	Mlh1p	Ntg2p	855203(Tax:4932)	854114(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ntg2p , a Saccharomyces_cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage , interacts with the DNA mismatch repair protein Mlh1p .
17082773	0	Mmp1	23,27	JNK	0,3	Mmp1	JNK	37949(Tax:7227)	44801(Tax:7227)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	JNK - and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila .
21920357	0	Mmp15	0,5	Snai1	28,33	Mmp15	Snai1	17388(Tax:10090)	20613(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development .
23936608	0	Mn-SOD	28,34	Age-related_hearing_loss	0,24	Mn-SOD	Age-related hearing loss	20656(Tax:10090)	22295(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Age-related_hearing_loss in Mn-SOD heterozygous_knockout mice .
1311566	0	Mn-superoxide_dismutase	13,36	interleukin-1	63,76	Mn-superoxide dismutase	Interleukin-6	6648	3569	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Induction of Mn-superoxide_dismutase by tumor necrosis factor , interleukin-1 and interleukin-6 in human hepatoma cells .
2222450	0	Mn-superoxide_dismutase	15,38	tumor_necrosis_factor-alpha	53,80	Mn-superoxide dismutase	tumor necrosis factor-alpha	6648	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of Mn-superoxide_dismutase expression by tumor_necrosis_factor-alpha : quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA .
22261313	0	MnSOD	58,63	Brain-derived_neurotrophic_factor	0,33	MnSOD	Brain-derived neurotrophic factor	6648	627	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor increases expression of MnSOD in human circulating angiogenic cells .
16850160	0	MnSOD	32,37	C/EBPbeta	0,9	MnSOD	C/EBPbeta	6648	1051	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	C/EBPbeta regulates TNF induced MnSOD expression and protection against apoptosis .
15705913	0	MnSOD	57,62	CAT	64,67	MnSOD	CAT	6648	847	Gene	Gene	MPO|dep|START_ENTITY MPO|dep|END_ENTITY	Polymorphisms in genes related to oxidative stress -LRB- MPO , MnSOD , CAT -RRB- and survival after treatment for breast_cancer .
20301895	0	MnSOD	94,99	CAT	89,92	MnSOD	CAT	6648	847	Gene	Gene	GPX1|compound|START_ENTITY GSTM1|dep|GPX1 GSTM1|dep|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20445800	0	MnSOD	86,91	CAT	81,84	MnSOD	CAT	6648	847	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
25436036	0	MnSOD	11,16	CAT	0,3	MnSOD	CAT	6648	847	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
18689799	0	MnSOD	36,41	DJ-1	54,58	MnSOD	DJ-1	6648	11315	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha : regulation by SUMOylation and oxidation .
20353787	0	MnSOD	13,18	ERK2	40,44	MnSOD	ERK2	6648	5594	Gene	Gene	START_ENTITY|nmod|translocation translocation|compound|END_ENTITY	ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells .
25436036	0	MnSOD	11,16	GPX1	5,9	MnSOD	GPX1	6648	2876	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
20301895	0	MnSOD	94,99	GSTM1	75,80	MnSOD	GSTM1	6648	2944	Gene	Gene	GPX1|compound|START_ENTITY END_ENTITY|dep|GPX1	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20445800	0	MnSOD	86,91	GSTM1	67,72	MnSOD	GSTM1	6648	2944	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
25436036	0	MnSOD	11,16	GSTM1	18,23	MnSOD	GSTM1	6648	2944	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	CAT , GPX1 , MnSOD , GSTM1 , GSTT1 , and GSTP1 genetic polymorphisms in chronic myeloid_leukemia : a case-control study .
20301895	0	MnSOD	94,99	GSTT1	82,87	MnSOD	GSTT1	6648	2952	Gene	Gene	GPX1|compound|START_ENTITY GSTM1|dep|GPX1 GSTM1|dep|CAT CAT|compound|END_ENTITY	-LSB- Lack of association between metabolic and antioxidant gene polymorphisms -LRB- GSTM1 , GSTT1 , CAT , MnSOD , GPX1 -RRB- and maternal quitting of smoking in pregnancy -- preliminary results -RSB- .
20445800	0	MnSOD	86,91	GSTT1	74,79	MnSOD	GSTT1	6648	2952	Gene	Gene	MPO|appos|START_ENTITY MPO|appos|END_ENTITY	Genetic Polymorphisms in Genes Related to Oxidative Stress -LRB- GSTP1 , GSTM1 , GSTT1 , CAT , MnSOD , MPO , eNOS -RRB- and Survival of Rectal_Cancer Patients after Radiotherapy .
12948282	0	MnSOD	32,37	Manganese_superoxide_dismutase	0,30	MnSOD	Manganese superoxide dismutase	6648	6648	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD -RRB- polymorphism , alpha-tocopherol supplementation and prostate_cancer risk in the alpha-tocopherol , beta-carotene cancer prevention study -LRB- Finland -RRB- .
17217237	0	MnSOD	38,43	Manganese_superoxide_dismutase	1,31	MnSOD	Manganese superoxide dismutase	6648	6648	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Manganese_superoxide_dismutase gene -LRB- MnSOD -RRB- polimorphism in schizophrenics with tardive_dyskinesia from central Poland -RSB- .
17582511	0	MnSOD	32,37	Manganese_superoxide_dismutase	0,30	MnSOD	Manganese superoxide dismutase	6648	6648	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD : Ala-9Val -RRB- gene polymorphism may not be associated with schizophrenia and tardive_dyskinesia .
18646267	0	MnSOD	32,37	Manganese_superoxide_dismutase	0,30	MnSOD	Manganese superoxide dismutase	6648	6648	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD -RRB- genetic polymorphism is associated with risk of early-onset prostate_cancer .
20357718	0	MnSOD	32,37	Manganese_superoxide_dismutase	0,30	MnSOD	Manganese superoxide dismutase	6648	6648	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Manganese_superoxide_dismutase -LRB- MnSOD -RRB- gene -LRB- Ala-9Val , Ile58Thr -RRB- polymorphism in patients with age-related_macular_degeneration -LRB- AMD -RRB- .
7476933	0	MnSOD	47,52	NF-kappa_B	87,97	MnSOD	NF-kappa B	6648	4790	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Thiol modulation of TNF_alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa_B .
7491977	0	MnSOD	42,47	NF-kappa_B	14,24	MnSOD	NF-kappa B	6648	4790	Gene	Gene	expression|compound|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of NF-kappa_B and elevation of MnSOD gene expression by thiol reducing agents in lung_adenocarcinoma -LRB- A549 -RRB- cells .
22732184	0	MnSOD	78,83	Sirt3	59,64	MnSOD	Sirt3	6648	23410	Gene	Gene	status|amod|START_ENTITY directing|dobj|status Exploring|advcl|directing Exploring|nmod|role role|nmod|END_ENTITY	Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity .
23886445	0	MnSOD	14,19	Sirt3	42,47	MnSOD	Sirt3	6648	23410	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis .
16850160	0	MnSOD	32,37	TNF	20,23	MnSOD	TNF	6648	7124	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	C/EBPbeta regulates TNF induced MnSOD expression and protection against apoptosis .
10465100	0	MnSOD	58,63	TNF-alpha	171,180	MnSOD	TNF-alpha	20656(Tax:10090)	21926(Tax:10090)	Gene	Gene	correction|appos|START_ENTITY plasmid/liposome|nsubj|correction plasmid/liposome|dep|therapy therapy|dep|modulation modulation|nmod|mRNA mRNA|nmod|END_ENTITY	Manganese -LSB- correction of Magnesium -RSB- superoxide dismutase -LRB- MnSOD -RRB- plasmid/liposome pulmonary radioprotective gene therapy : modulation of irradiation-induced mRNA for IL-I , TNF-alpha , and TGF-beta correlates with delay of organizing_alveolitis / fibrosis .
12032862	0	MnSOD	43,48	TNF-alpha	25,34	MnSOD	TNF-alpha	6648	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Tamoxifen enhancement of TNF-alpha induced MnSOD expression : modulation of NF-kappaB dimerization .
12829021	0	MnSOD	68,73	TNF-alpha	125,134	MnSOD	TNF-alpha	6648	7124	Gene	Gene	dismutase|appos|START_ENTITY transgene|nmod|dismutase Overexpression|nmod|transgene cl|nsubj|Overexpression cl|ccomp|prevents prevents|nmod|END_ENTITY	Overexpression of the transgene for manganese_superoxide dismutase -LRB- MnSOD -RRB- in 32D cl 3 cells prevents apoptosis induction by TNF-alpha , IL-3 withdrawal , and ionizing radiation .
11264281	0	MnSOD	48,53	Tumor_necrosis_factor-alpha	0,27	MnSOD	Tumor necrosis factor-alpha	6648	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha selectively induces MnSOD expression via mitochondria-to-nucleus signaling , whereas interleukin-1beta utilizes an alternative pathway .
21671088	0	MnSOD	63,68	manganese-containing_superoxide_dismutase	20,61	MnSOD	manganese-containing superoxide dismutase	6648	6648	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Manganese regulates manganese-containing_superoxide_dismutase -LRB- MnSOD -RRB- expression in the primary broiler_myocardial_cells .
27055786	0	MnSOD	52,57	manganese_superoxide_dismutase	20,50	MnSOD	manganese superoxide dismutase	6648	6648	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between manganese_superoxide_dismutase -LRB- MnSOD -RRB- polymorphism and prostate_cancer susceptibility : a meta-analysis .
20712406	0	MnSOD	8,13	p53	54,57	MnSOD	p53	6648	7157	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of MnSOD and p66shc in mitochondrial response to p53 .
21047768	0	Mnk	0,3	eIF4E	37,42	Mnk	eIF4E	538	1977	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Mnk mediates integrin a6b4-dependent eIF4E phosphorylation and translation of VEGF mRNA .
21576361	0	Mnk1	128,132	eIF4G1	110,116	Mnk1	eIF4G1	8569	1981	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4G1 -LRB- eIF4G1 -RRB- by protein_kinase_C -LCB- alpha -RCB- regulates eIF4G1 binding to Mnk1 .
21576361	0	Mnk1	128,132	eIF4G1	65,71	Mnk1	eIF4G1	8569	1981	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4G1 -LRB- eIF4G1 -RRB- by protein_kinase_C -LCB- alpha -RCB- regulates eIF4G1 binding to Mnk1 .
16856496	0	Mnk2	20,24	VHL	33,36	Mnk2	VHL	2872	7428	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction between Mnk2 and CBC -LRB- VHL -RRB- ubiquitin ligase E3 complex .
22684071	0	MoaC2	133,138	molybdenum_cofactor_biosynthesis_protein_C	89,131	MoaC2	molybdenum cofactor biosynthesis protein C	885826(Tax:83332)	885826(Tax:83332)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Overexpression , purification , crystallization and preliminary X-ray analysis of putative molybdenum_cofactor_biosynthesis_protein_C -LRB- MoaC2 -RRB- from Mycobacterium_tuberculosis_H37Rv .
25048710	0	Moesin	15,21	P-glycoprotein	81,95	Moesin	P-glycoprotein	4478	5243	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Moesin in the Development of Morphine Analgesic Tolerance through P-glycoprotein at the Blood-Brain Barrier .
20215404	0	Moesin	110,116	Slik	93,97	Moesin	Slik	31816(Tax:7227)	37893(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY regulate|dobj|activity END_ENTITY|xcomp|regulate	Sip1 , the Drosophila orthologue of EBP50/NHERF1 , functions with the sterile 20 family kinase Slik to regulate Moesin activity .
8360275	0	Moesin	0,6	ezrin	13,18	Moesin	ezrin	4478	7430	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	Moesin , like ezrin , colocalizes with actin in the cortical cytoskeleton in cultured cells , but its expression is more variable .
9928947	0	Moesin	0,6	ezrin	73,78	Moesin	ezrin	4478	7430	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Moesin , the major ERM protein of lymphocytes and platelets , differs from ezrin in its insensitivity to calpain .
21167305	0	Moesin-ezrin-radixin-like_protein	0,33	merlin	35,41	Moesin-ezrin-radixin-like protein	merlin	4771	4771	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Moesin-ezrin-radixin-like_protein -LRB- merlin -RRB- mediates protein interacting with the carboxyl terminus-1 -LRB- PICT-1 -RRB- - induced growth inhibition of glioblastoma cells in the nucleus .
20215113	0	Moloney_leukemia_virus_10	0,25	MOV10	27,32	Moloney leukemia virus 10	MOV10	4343	4343	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Moloney_leukemia_virus_10 -LRB- MOV10 -RRB- protein inhibits retrovirus replication .
16301316	0	Mon2	0,4	Dop1	57,61	Mon2	Dop1	855420(Tax:4932)	851719(Tax:4932)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Mon2 , a relative of large Arf exchange factors , recruits Dop1 to the Golgi apparatus .
23520550	0	MondoA	52,58	Thioredoxin-interacting_protein	0,31	MondoA	Thioredoxin-interacting protein	22877	10628	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Thioredoxin-interacting_protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses .
23631812	0	MondoA	0,6	thioredoxin-interacting_protein	64,95	MondoA	thioredoxin-interacting protein	22877	10628	Gene	Gene	adenine_nucleotides|compound|START_ENTITY adenine_nucleotides|dep|induction induction|nmod|END_ENTITY	MondoA senses adenine_nucleotides : transcriptional induction of thioredoxin-interacting_protein .
24204926	0	Monoacylglycerol_lipase	0,23	MAGL	25,29	Monoacylglycerol lipase	MAGL	23945(Tax:10090)	23945(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Monoacylglycerol_lipase -LRB- MAGL -RRB- inhibition attenuates acute_lung_injury in mice .
2696882	2	Monoamine_oxidase	74,91	MAO	93,96	Monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Monoamine_oxidase -LRB- MAO -RRB- activity in the rat brain after porta - caval shunt using 2 different methods -RSB- .
24011391	0	Monoamine_oxidase-B	0,19	MAO-B	21,26	Monoamine oxidase-B	MAO-B	4129	4129	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Monoamine_oxidase-B -LRB- MAO-B -RRB- inhibitors : implications for disease-modification in Parkinson 's _ disease .
19168625	0	Monoamine_oxidase_A	0,19	MAOA	26,30	Monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Monoamine_oxidase_A gene -LRB- MAOA -RRB- predicts behavioral_aggression following provocation .
20046877	0	Monoamine_oxidase_A	0,19	MAOA	26,30	Monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Monoamine_oxidase_A gene -LRB- MAOA -RRB- associated with attitude towards longshot risks .
24173666	0	Monoamine_oxidase_A	57,76	MAOA	83,87	Monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sudden_infant_death_syndrome -LRB- SIDS -RRB- and polymorphisms in Monoamine_oxidase_A gene -LRB- MAOA -RRB- : a revisit .
25281618	0	Monocarboxylate_Transporter-1	14,43	MCT1	45,49	Monocarboxylate Transporter-1	MCT1	6566	6566	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of Monocarboxylate_Transporter-1 -LRB- MCT1 -RRB- by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport .
26024713	0	Monocarboxylate_Transporter_1	117,146	EMMPRIN	24,31	Monocarboxylate Transporter 1	EMMPRIN	6566	682	Gene	Gene	Apoptosis|nmod|START_ENTITY Apoptosis|compound|END_ENTITY	Recombinant Multivalent EMMPRIN Extracellular Domain Induces U937 Human Leukemia Cell Apoptosis by Downregulation of Monocarboxylate_Transporter_1 and Activation of Procaspase-9 .
26024713	0	Monocarboxylate_Transporter_1	117,146	EMMPRIN	24,31	Monocarboxylate Transporter 1	EMMPRIN	6566	682	Gene	Gene	Apoptosis|nmod|START_ENTITY Apoptosis|compound|END_ENTITY	Recombinant Multivalent EMMPRIN Extracellular Domain Induces U937 Human Leukemia Cell Apoptosis by Downregulation of Monocarboxylate_Transporter_1 and Activation of Procaspase-9 .
25320343	0	Monocarboxylate_transporters_1_and_4	0,36	PPARa	67,72	Monocarboxylate transporters 1 and 4	PPARa	9122	5465	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Monocarboxylate_transporters_1_and_4 : expression and regulation by PPARa in ovine ruminal epithelial cells .
8877395	0	Monoclonal_nonspecific_suppressor_factor_beta	0,45	TNF-alpha	85,94	Monoclonal nonspecific suppressor factor beta	TNF-alpha	14109(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Monoclonal_nonspecific_suppressor_factor_beta -LRB- MNSF_beta -RRB- inhibits the production of TNF-alpha by lipopolysaccharide-activated macrophages .
7664805	0	Monoclonal_nonspecific_suppressor_factor_beta	0,45	interleukin-4	55,68	Monoclonal nonspecific suppressor factor beta	interleukin-4	14109(Tax:10090)	16189(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Monoclonal_nonspecific_suppressor_factor_beta inhibits interleukin-4 secretion by a type-2 helper T cell clone .
25586482	0	Monocyte_Chemoattractant_Protein-1	47,81	apoM	111,115	Monocyte Chemoattractant Protein-1	apoM	6347	55937	Gene	Gene	Production|compound|START_ENTITY Production|dep|END_ENTITY	Propofol Attenuates Lipopolysaccharide-Induced Monocyte_Chemoattractant_Protein-1 Production Through Enhancing apoM and foxa2 Expression in HepG2 Cells .
23977412	0	Monocyte_Chemotactic_Protein-1	14,44	TREK-1	102,108	Monocyte Chemotactic Protein-1	TREK-1	6347	3776	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of Monocyte_Chemotactic_Protein-1 secretion by the Two-Pore-Domain Potassium -LRB- K2P -RRB- channel TREK-1 in human alveolar epithelial cells .
22904274	0	Monocyte_chemoattractant_protein-1	0,34	CCR2	35,39	Monocyte chemoattractant protein-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|axis axis|compound|END_ENTITY	Monocyte_chemoattractant_protein-1 / CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations .
10209485	0	Monocyte_chemoattractant_protein-1	0,34	MCP-1	36,41	Monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- expression in primary_lymphoepithelioma-like_carcinomas -LRB- LELCs -RRB- of the lung .
15288699	0	Monocyte_chemoattractant_protein-1	0,34	MCP-1	36,41	Monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene polymorphism and risk of Alzheimer 's _ disease in Italians .
10843667	0	Monocyte_chemoattractant_protein-1	0,34	matrix_metalloproteinase-1	77,103	Monocyte chemoattractant protein-1	matrix metalloproteinase-1	6347	4312	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Monocyte_chemoattractant_protein-1 enhances gene expression and synthesis of matrix_metalloproteinase-1 in human fibroblasts by an autocrine IL-1_alpha loop .
11359653	0	Monocyte_chemoattractant_protein-1	0,34	p38	98,101	Monocyte chemoattractant protein-1	p38	24770(Tax:10116)	81649(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|dep|role role|nmod|END_ENTITY	Monocyte_chemoattractant_protein-1 production by intestinal epithelial cells in vitro : a role for p38 in epithelial chemokine expression .
9009224	0	Monocyte_chemoattractant_protein-2	0,34	MCP-1_receptor	69,83	Monocyte chemoattractant protein-2	MCP-1 receptor	6355	729230	Gene	Gene	exert|nsubj|START_ENTITY exert|nmod|END_ENTITY	Monocyte_chemoattractant_protein-2 can exert its effects through the MCP-1_receptor -LRB- CC CKR2B -RRB- .
7759884	0	Monocyte_chemoattractant_protein-3	0,34	monocyte_chemoattractant_protein-1_receptor	116,159	Monocyte chemoattractant protein-3	monocyte chemoattractant protein-1 receptor	6354	729230	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Monocyte_chemoattractant_protein-3 , but not monocyte_chemoattractant_protein-2 , is a functional ligand of the human monocyte_chemoattractant_protein-1_receptor .
16936342	0	Monocyte_chemoattractant_protein_1	0,34	MCP-1	36,41	Monocyte chemoattractant protein 1	MCP-1	6347	6347	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- gene polymorphism is not associated with severe and cerebral_malaria in Thailand .
8283136	0	Monocyte_chemoattractant_protein_1	0,34	MCP-1	36,41	Monocyte chemoattractant protein 1	MCP-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- expression occurs in toxic rat liver_injury and human liver_disease .
16085694	0	Monocyte_chemoattractant_protein_1	0,34	cyclooxygenase_2	50,66	Monocyte chemoattractant protein 1	cyclooxygenase 2	6347	5743	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Monocyte_chemoattractant_protein_1 and macrophage cyclooxygenase_2 expression in colonic_adenoma .
8679249	0	Monocyte_chemotactic_protein-1	0,30	MCP-1	32,37	Monocyte chemotactic protein-1	MCP-1	6347	6347	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- mRNA is down-regulated in human dermal fibroblasts by dexamethasone : differential regulation by TGF-beta .
9115216	0	Monocyte_chemotactic_protein-2	0,30	CCR1	44,48	Monocyte chemotactic protein-2	CCR1	6355	1230	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Monocyte_chemotactic_protein-2 -LRB- MCP-2 -RRB- uses CCR1 and CCR2B as its functional receptors .
11027635	0	Monocyte_chemotactic_protein_1	0,30	IL-1beta	43,51	Monocyte chemotactic protein 1	IL-1beta	6347	3553	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Monocyte_chemotactic_protein_1 upregulates IL-1beta expression in human monocytes .
22555025	0	Morg1	40,45	Angiotensin_II	0,14	Morg1	Angiotensin II	67836(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II differentially regulates Morg1 expression in kidney cells .
9582077	0	Mort1	43,48	FADD	37,41	Mort1	FADD	8772	8772	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	NMR structure and mutagenesis of the FADD -LRB- Mort1 -RRB- death-effector domain .
17050040	0	Mortalin	0,8	APOE	25,29	Mortalin	APOE	15526(Tax:10090)	348	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Mortalin is regulated by APOE in hippocampus of AD patients and by human APOE in TR mice .
1830371	0	Mos	55,58	MPF_and_cytostatic_factor	28,53	Mos	MPF and cytostatic factor	397924(Tax:8355)	380246(Tax:8355)	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Independent inactivation of MPF_and_cytostatic_factor -LRB- Mos -RRB- upon fertilization of Xenopus eggs .
9121438	0	Mos	43,46	Mos	60,63	Mos	Mos	397924(Tax:8355)	397924(Tax:8355)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	The casein kinase II beta subunit binds to Mos and inhibits Mos activity .
9121438	0	Mos	60,63	Mos	43,46	Mos	Mos	397924(Tax:8355)	397924(Tax:8355)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	The casein kinase II beta subunit binds to Mos and inhibits Mos activity .
10561505	0	Mos	14,17	MyoD	0,4	Mos	MyoD	4342	4654	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	MyoD binds to Mos and inhibits the Mos/MAP kinase pathway .
9001211	0	Mos	0,3	MyoD	74,78	Mos	MyoD	24559(Tax:10116)	17927(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|advcl|promoting promoting|dobj|heterodimerization heterodimerization|nmod|proteins proteins|compound|END_ENTITY	Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins .
11959823	0	Mos	15,18	Myt1	59,63	Mos	Myt1	397924(Tax:8355)	397982(Tax:8355)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A new role for Mos in Xenopus oocyte maturation : targeting Myt1 independently of MAPK .
10072389	0	Mos	0,3	Xe-Wee1	25,32	Mos	Xe-Wee1	397924(Tax:8355)	398017(Tax:8355)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus .
15341746	0	Mos	0,3	p42_MAPK	39,47	Mos	p42 MAPK	397924(Tax:8355)	398985(Tax:8355)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Mos mediates the mitotic activation of p42_MAPK in Xenopus egg extracts .
20186124	0	Mos	76,79	p53	54,57	Mos	p53	4342	7157	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Multipolar mitosis of tetraploid cells : inhibition by p53 and dependency on Mos .
12571241	0	Mot1	0,4	TATA-binding_protein	48,68	Mot1	TATA-binding protein	856023(Tax:4932)	856891(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Mot1 regulates the DNA binding activity of free TATA-binding_protein in an ATP-dependent manner .
10982825	0	Mot3	30,34	ANB1	83,87	Mot3	ANB1	855092(Tax:4932)	853506(Tax:4932)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of transcription factor Mot3 and chromatin in repression of the hypoxic gene ANB1 in yeast .
9458777	0	Motilin	0,7	insulin	35,42	Motilin	insulin	481748(Tax:9615)	483665(Tax:9615)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|release release|nmod|END_ENTITY	Motilin controls cyclic release of insulin through vagal cholinergic muscarinic pathways in fasted dogs .
9124345	0	Motilin	0,7	pancreatic_polypeptide	53,75	Motilin	pancreatic polypeptide	481748(Tax:9615)	490944(Tax:9615)	Gene	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Motilin is a biosignal controlling cyclic release of pancreatic_polypeptide via the vagus in fasted dogs .
14735195	0	Motility-related_protein-1	0,26	CD9	34,37	Motility-related protein-1	CD9	928	928	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Motility-related_protein-1 -LRB- MRP-1 / CD9 -RRB- expression can predict disease-free survival in patients with squamous_cell_carcinoma of the head_and_neck .
7664290	0	Motility_related_protein_1	0,26	CD9	34,37	Motility related protein 1	CD9	928	928	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Motility_related_protein_1 -LRB- MRP-1 / CD9 -RRB- expression : inverse correlation with metastases in breast_cancer .
26307549	0	Mpeg1	11,16	Perforin-2	0,10	Mpeg1	Perforin-2	219972	219972	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Perforin-2 / Mpeg1 and other pore-forming proteins throughout evolution .
26966248	0	Mph1	20,24	Mte1	0,4	Mph1	Mte1	7272	10965	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance .
17293484	0	Mpk1	107,111	Slt2	101,105	Mpk1	Slt2	856425(Tax:4932)	856425(Tax:4932)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	In the yeast heat_shock response , Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 -LRB- Mpk1 -RRB- mitogen-activated protein kinase required for cell integrity .
7565726	0	Mpk1	92,96	Slt2	98,102	Mpk1	Slt2	856425(Tax:4932)	856425(Tax:4932)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 -LRB- Slt2 -RRB- mitogen-activated protein kinase pathway .
9111331	0	Mpk1	144,148	Slt2	150,154	Mpk1	Slt2	856425(Tax:4932)	856425(Tax:4932)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Characterization of a serum response factor-like protein in Saccharomyces_cerevisiae , Rlm1 , which has transcriptional activity regulated by the Mpk1 -LRB- Slt2 -RRB- mitogen-activated protein kinase pathway .
14507918	0	Mpk1	5,9	Xp42	0,4	Mpk1	Xp42	398985(Tax:8355)	398985(Tax:8355)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Xp42 -LRB- Mpk1 -RRB- activation is not required for germinal vesicle_breakdown but for Raf complete phosphorylation in insulin-stimulated Xenopus oocytes .
21263445	0	Mpl	42,45	PlagL2	25,31	Mpl	PlagL2	17480(Tax:10090)	54711(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells .
20113333	0	Mpl	91,94	STAT3	134,139	Mpl	STAT3	4352	6774	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Screening for MPL mutations in essential_thrombocythemia and primary myelofibrosis : normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets .
10517496	0	Mpl	71,74	Thrombopoietin	0,14	Mpl	Thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY protein|acl:relcl|binds induces|dobj|protein induces|nsubj|END_ENTITY	Thrombopoietin induces an SH2-containing protein , CIS1 , which binds to Mpl : involvement of the ubiquitin proteosome pathway .
10216080	0	Mpl	25,28	thrombopoietin	79,93	Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY independent|nsubj|expression independent|nmod|END_ENTITY	High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin .
10381535	0	Mpl	83,86	thrombopoietin	135,149	Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY Deletion|nmod|receptor results|nsubj|Deletion results|nmod|growth growth|nmod|END_ENTITY	Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding .
10671297	0	Mpl	59,62	thrombopoietin	109,123	Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	loop|nmod|START_ENTITY essential|nsubj|loop essential|nmod|high-affinity high-affinity|nmod|END_ENTITY	Tyrosine 462 of the membrane-proximal F ' - G ' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin .
10971406	0	Mpl	42,45	thrombopoietin	17,31	Mpl	thrombopoietin	4352	7066	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Mutations in the thrombopoietin receptor , Mpl , in children with congenital_amegakaryocytic_thrombocytopenia .
12006617	0	Mpl	79,82	thrombopoietin	20,34	Mpl	thrombopoietin	4352	7066	Gene	Gene	level|nmod|START_ENTITY Distinct|advcl|level Distinct|dobj|effects effects|nmod|END_ENTITY	Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells .
15071178	0	Mpl	21,24	thrombopoietin	117,131	Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	screen|nmod|START_ENTITY causes|nsubj|screen causes|dobj|production production|nmod|platelets platelets|nmod|absence absence|nmod|END_ENTITY	Suppressor screen in Mpl - / - mice : c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling .
20667107	0	Mpl	51,54	thrombopoietin	26,40	Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|receptor receptor|compound|END_ENTITY	Expression pattern of the thrombopoietin receptor -LRB- Mpl -RRB- in the murine central nervous system .
9685168	0	Mpl	0,3	thrombopoietin	80,94	Mpl	thrombopoietin	4352	7066	Gene	Gene	START_ENTITY|nmod|virus virus|nmod|isolation isolation|nmod|END_ENTITY	Mpl : from an acute myeloproliferative virus to the isolation of the long sought thrombopoietin .
8954807	0	Mpp1	55,59	p55	50,53	Mpp1	p55	17524(Tax:10090)	17524(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	cDNA sequence and genomic structure of the murine p55 -LRB- Mpp1 -RRB- gene .
14990745	0	Mpp10p	11,17	Imp4	40,44	Mpp10p	Imp4	853458(Tax:4932)	855649(Tax:4932)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Two-hybrid Mpp10p interaction-defective Imp4 proteins are not interaction defective in vivo but do confer specific pre-rRNA processing defects in Saccharomyces_cerevisiae .
16520334	0	Mpp4	0,4	Psd95	14,19	Mpp4	Psd95	227157(Tax:10090)	13385(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse .
22732840	0	Mps1	0,4	Aurora_B	47,55	Mps1	Aurora B	219972	9212	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|nmod|END_ENTITY	Mps1 promotes rapid centromere accumulation of Aurora_B .
18243099	0	Mps1	0,4	Borealin	20,28	Mps1	Borealin	7272	55143	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Mps1 phosphorylates Borealin to control Aurora_B activity and chromosome alignment .
26354417	0	Mps1	41,45	Centrin_3	0,9	Mps1	Centrin 3	7272	1070	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Centrin_3 is an inhibitor of centrosomal Mps1 and antagonizes Centrin_2 function .
26804907	0	Mps1	0,4	Hsp90	33,38	Mps1	Hsp90	219972	3320	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Mps1 Mediated Phosphorylation of Hsp90 Confers Renal_Cell_Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors .
26804907	0	Mps1	0,4	Hsp90	99,104	Mps1	Hsp90	219972	3320	Gene	Gene	Phosphorylation|compound|START_ENTITY Confers|nsubj|Phosphorylation Confers|nmod|Inhibitors Inhibitors|compound|END_ENTITY	Mps1 Mediated Phosphorylation of Hsp90 Confers Renal_Cell_Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors .
25246613	0	Mps1	17,21	Knl1	41,45	Mps1	Knl1	219972	57082	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing .
22935710	0	Mps1	48,52	VDAC3	0,5	Mps1	VDAC3	219972	7419	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes .
11278681	0	Mps1p	6,11	Spc110p	54,61	Mps1p	Spc110p	851533(Tax:4932)	851957(Tax:4932)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain .
11827982	0	Mps1p	25,30	Spc42p	100,106	Mps1p	Spc42p	851533(Tax:4932)	853824(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|assembly assembly|nmod|END_ENTITY	The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p .
9154842	0	Mpt5p	25,30	Sst2p	46,51	Mpt5p	Sst2p	852697(Tax:4932)	851173(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Saccharomyces_cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest .
16978845	0	Mptx	41,45	mucosal_pentraxin	22,39	Mptx	mucosal pentraxin	289243(Tax:10116)	289243(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Complex regulation of mucosal_pentraxin -LRB- Mptx -RRB- revealed by discrete micro-anatomical locations in colon .
9658163	0	Mpv17	52,57	MMP-2	68,73	Mpv17	MMP-2	17527(Tax:10090)	17390(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Expression of the recessive glomerulosclerosis gene Mpv17 regulates MMP-2 expression in fibroblasts , the kidney , and the inner ear of mice .
19457865	0	Mrc1	67,71	Mec1	38,42	Mrc1	Mec1	850297(Tax:4932)	852433(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Reconstitution of Rad53 activation by Mec1 through adaptor protein Mrc1 .
22231403	0	Mre11	0,5	CDK2	78,82	Mre11	CDK2	4361	1017	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2 .
25788520	0	Mre11	16,21	FGFR2	0,5	Mre11	FGFR2	4361	2263	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FGFR2 regulates Mre11 expression and double-strand break repair via the MEK-ERK-POU1F1 pathway in breast tumorigenesis .
11470800	0	Mre11	25,30	Rad50	17,22	Mre11	Rad50	855264(Tax:4932)	855471(Tax:4932)	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces_cerevisiae by electron microscopy .
8756642	0	Mre11	48,53	Rad50	6,11	Mre11	Rad50	4361	10111	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	Human Rad50 is physically associated with human Mre11 : identification of a conserved multiprotein complex implicated in recombinational DNA repair .
12660252	0	Mre11	50,55	histone_H2AX	19,31	Mre11	histone H2AX	4361	3014	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of histone_H2AX and activation of Mre11 , Rad50 , and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes .
16697365	0	MrgA1	78,83	Salusin_beta	0,12	MrgA1	Salusin beta	233221(Tax:10090)	27433	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Salusin_beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1 .
18757529	0	Mrp	52,55	Nrf2	0,4	Mrp	Nrf2	17250(Tax:10090)	18024(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Nrf2 - and PPAR_alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic_acid and perfluorodecanoic_acid .
10820430	0	Mrp1	85,89	P-glycoprotein	25,39	Mrp1	P-glycoprotein	24565(Tax:10116)	287115(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Functional expression of P-glycoprotein and multidrug_resistance-associated_protein -LRB- Mrp1 -RRB- in primary cultures of rat astrocytes .
16426233	0	Mrp2	38,42	ABCC2	44,49	Mrp2	ABCC2	12780(Tax:10090)	12780(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of Nrf2 in the regulation of the Mrp2 -LRB- ABCC2 -RRB- gene .
12145812	0	Mrp2	73,77	Abcc2	79,84	Mrp2	Abcc2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Organ-specific alterations in RAR_alpha : RXR_alpha abundance regulate rat Mrp2 -LRB- Abcc2 -RRB- expression in obstructive cholestasis .
18088505	0	Mrp2	15,19	Abcc2	21,26	Mrp2	Abcc2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Mrp2 -LRB- Abcc2 -RRB- in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver .
19996279	0	Mrp2	7,11	Bcrp1	39,44	Mrp2	Bcrp1	12780(Tax:10090)	26357(Tax:10090)	Gene	Gene	Abcc2|appos|START_ENTITY Abcc2|appos|END_ENTITY	Abcc2 -LRB- Mrp2 -RRB- , Abcc3 -LRB- Mrp3 -RRB- , and Abcg2 -LRB- Bcrp1 -RRB- are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo .
22057277	0	Mrp2	59,63	Fyn	22,25	Mrp2	Fyn	25303(Tax:10116)	25150(Tax:10116)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	The Src family kinase Fyn mediates hyperosmolarity-induced Mrp2 and Bsep retrieval from canalicular membrane .
19088030	0	Mrp2	17,21	Mrp3	34,38	Mrp2	Mrp3	12780(Tax:10090)	76408(Tax:10090)	Gene	Gene	Abcc2|appos|START_ENTITY Abcc2|appos|END_ENTITY	Impact of Abcc2 -LRB- Mrp2 -RRB- and Abcc3 -LRB- Mrp3 -RRB- on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate .
12167307	0	Mrp2	50,54	Multidrug_Resistance_Protein_2	18,48	Mrp2	Multidrug Resistance Protein 2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of rat Multidrug_Resistance_Protein_2 -LRB- Mrp2 -RRB- in male and female rats during normal and pregnenolone-16alpha-carbonitrile -LRB- PCN -RRB- - induced postnatal ontogeny .
20404332	0	Mrp2	17,21	NHERF-1	0,7	Mrp2	NHERF-1	12780(Tax:10090)	26941(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function .
16426233	0	Mrp2	38,42	Nrf2	8,12	Mrp2	Nrf2	12780(Tax:10090)	18024(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of Nrf2 in the regulation of the Mrp2 -LRB- ABCC2 -RRB- gene .
15507541	0	Mrp2	70,74	multidrug_resistance-associated_protein_2	27,68	Mrp2	multidrug resistance-associated protein 2	403632(Tax:9615)	403632(Tax:9615)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Functional analysis of dog multidrug_resistance-associated_protein_2 -LRB- Mrp2 -RRB- in comparison with rat Mrp2 .
19088030	0	Mrp3	34,38	Mrp2	17,21	Mrp3	Mrp2	76408(Tax:10090)	12780(Tax:10090)	Gene	Gene	Abcc2|appos|START_ENTITY Abcc2|appos|END_ENTITY	Impact of Abcc2 -LRB- Mrp2 -RRB- and Abcc3 -LRB- Mrp3 -RRB- on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate .
11481620	0	Mrp3	61,65	multidrug_resistance_protein_3	29,59	Mrp3	multidrug resistance protein 3	140668(Tax:10116)	140668(Tax:10116)	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of basolateral multidrug_resistance_protein_3 -LRB- Mrp3 -RRB- in cholestatic rat liver .
17767165	0	Mrp8	0,4	Toll-like_receptor_4	44,64	Mrp8	Toll-like receptor 4	6279	7099	Gene	Gene	activators|nsubj|START_ENTITY activators|nmod|END_ENTITY	Mrp8 and Mrp14 are endogenous activators of Toll-like_receptor_4 , promoting lethal , endotoxin-induced shock .
18675571	0	Mrps6	208,213	mitochondrial_ribosomal_protein_subunit_6	165,206	Mrps6	mitochondrial ribosomal protein subunit 6	121022(Tax:10090)	121022(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the null murine sodium/myo-inositol cotransporter 1 -LRB- Smit1 or Slc5a3 -RRB- phenotype : myo-inositol rescue is independent of expression of its cognate mitochondrial_ribosomal_protein_subunit_6 -LRB- Mrps6 -RRB- gene and of phosphatidylinositol levels in neonatal brain .
11254124	0	Mrs2p	64,69	Lpe10p	41,47	Mrs2p	Lpe10p	854511(Tax:4932)	856045(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The mitochondrial inner membrane protein Lpe10p , a homologue of Mrs2p , is essential for magnesium homeostasis and group II intron splicing in yeast .
26494001	0	Mrt4	28,32	MRTO4	42,47	Mrt4	MRTO4	100009675	51154	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Molecular behavior of human Mrt4 protein , MRTO4 , in stress conditions is regulated by its C-terminal region .
19789271	0	Mrt4	82,86	ribosomal_protein_P0	25,45	Mrt4	ribosomal protein P0	853860(Tax:4932)	851052(Tax:4932)	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role and dynamics of the ribosomal_protein_P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces_cerevisiae .
24732795	0	Msa1	68,72	Tec1	26,30	Msa1	Tec1	854232(Tax:4932)	852377(Tax:4932)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development .
16337661	0	Msh1p	29,34	Cce1p	71,76	Msh1p	Cce1p	856520(Tax:4932)	853858(Tax:4932)	Gene	Gene	contributions|nmod|START_ENTITY contributions|dep|END_ENTITY	Overlapping contributions of Msh1p and putative recombination proteins Cce1p , Din7p , and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces_cerevisiae .
14568978	0	Msh2	0,4	ATPase	5,11	Msh2	ATPase	17685(Tax:10090)	13417(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination .
12743174	0	Msh2	74,78	Mlh1	0,4	Msh2	Mlh1	17685(Tax:10090)	17350(Tax:10090)	Gene	Gene	recombination|nmod|START_ENTITY function|nmod|recombination function|nsubj|END_ENTITY	Mlh1 can function in antibody class switch recombination independently of Msh2 .
16600868	0	Msh2	62,66	Msh6	14,18	Msh2	Msh6	4436	2956	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|Inhibition Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of Msh6 ATPase activity by mispaired DNA induces a Msh2 -LRB- ATP -RRB- - Msh6 -LRB- ATP -RRB- state capable of hydrolysis-independent movement along DNA .
16600868	0	Msh2	62,66	Msh6	72,76	Msh2	Msh6	4436	2956	Gene	Gene	induces|dobj|START_ENTITY induces|parataxis|state state|nsubj|END_ENTITY	Inhibition of Msh6 ATPase activity by mispaired DNA induces a Msh2 -LRB- ATP -RRB- - Msh6 -LRB- ATP -RRB- state capable of hydrolysis-independent movement along DNA .
20567595	3	Msh2	892,896	Msh6	901,905	Msh2	Msh6	17685(Tax:10090)	17688(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The similar defects on switching in Msh2 -LRB- - / - -RRB- , Msh2 -LRB- - / - -RRB- Msh6 -LRB- - / - -RRB- and Msh2 -LRB- - / - -RRB- Msh6 -LRB- - / - -RRB- Msh3 -LRB- - / - -RRB- mice confirm that MutSalpha but not MutSbeta plays an important role in CSR .
23857323	0	Msh2	96,100	Ung2	101,105	Msh2	Ung2	4436	7374	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2 + Ung2 hybrid pathway .
10556423	0	Msh5	65,69	MutS_homolog_5	49,63	Msh5	MutS homolog 5	17687(Tax:10090)	17687(Tax:10090)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of the mouse MutS_homolog_5 : Msh5 .
16600868	0	Msh6	14,18	Msh2	62,66	Msh6	Msh2	2956	4436	Gene	Gene	activity|amod|START_ENTITY Inhibition|nmod|activity induces|nsubj|Inhibition induces|dobj|END_ENTITY	Inhibition of Msh6 ATPase activity by mispaired DNA induces a Msh2 -LRB- ATP -RRB- - Msh6 -LRB- ATP -RRB- state capable of hydrolysis-independent movement along DNA .
16600868	0	Msh6	72,76	Msh2	62,66	Msh6	Msh2	2956	4436	Gene	Gene	state|nsubj|START_ENTITY induces|parataxis|state induces|dobj|END_ENTITY	Inhibition of Msh6 ATPase activity by mispaired DNA induces a Msh2 -LRB- ATP -RRB- - Msh6 -LRB- ATP -RRB- state capable of hydrolysis-independent movement along DNA .
20567595	3	Msh6	901,905	Msh2	892,896	Msh6	Msh2	17688(Tax:10090)	17685(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The similar defects on switching in Msh2 -LRB- - / - -RRB- , Msh2 -LRB- - / - -RRB- Msh6 -LRB- - / - -RRB- and Msh2 -LRB- - / - -RRB- Msh6 -LRB- - / - -RRB- Msh3 -LRB- - / - -RRB- mice confirm that MutSalpha but not MutSbeta plays an important role in CSR .
25782991	0	Msi2	47,51	Musashi-1	20,29	Msi2	Musashi-1	76626(Tax:10090)	17690(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus .
22713118	0	Msi3p	17,22	Sse1p	66,71	Msi3p	Sse1p	855998(Tax:4932)	855998(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Candida_albicans Msi3p , a homolog of the Saccharomyces_cerevisiae Sse1p of the Hsp70 family , is involved in cell growth and fluconazole tolerance .
16006618	0	Mso1p	155,160	Sec1p	125,130	Mso1p	Sec1p	855785(Tax:4932)	851742(Tax:4932)	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	A gene truncation strategy generating N - and C-terminal deletion variants of proteins for functional studies : mapping of the Sec1p binding domain in yeast Mso1p by a Mu in vitro transposition-based approach .
22101863	0	Msq1	30,34	Ly6	17,20	Msq1	Ly6	100035637(Tax:10090)	17062(Tax:10090)	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Polymorphisms in Ly6 genes in Msq1 encoding susceptibility to mouse adenovirus type 1 .
17239346	0	MsrA	22,26	Ecdysone	0,8	MsrA	Ecdysone	39675(Tax:7227)	38291(Tax:7227)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Ecdysone induction of MsrA protects against oxidative stress in Drosophila .
17519015	0	MsrB1	135,140	methionine_sulfoxide_reductase_B1	100,133	MsrB1	methionine sulfoxide reductase B1	51734	51734	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Important roles of multiple Sp1 binding sites and epigenetic modifications in the regulation of the methionine_sulfoxide_reductase_B1 -LRB- MsrB1 -RRB- promoter .
19710419	0	Mss51	18,23	Cox1	44,48	Mss51	Cox1	850900(Tax:4932)	854598(Tax:4932)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces_cerevisiae mitochondria .
10803883	0	Mss51p	0,6	Cox1p	119,124	Mss51p	Cox1p	850900(Tax:4932)	854598(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|synthesis synthesis|nmod|END_ENTITY	Mss51p , a putative translational activator of cytochrome_c_oxidase_subunit-1 -LRB- COX1 -RRB- mRNA , is required for synthesis of Cox1p in Saccharomyces_cerevisiae .
14592991	0	Mss51p	0,6	Cox1p	30,35	Mss51p	Cox1p	118490	4512	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|synthesis synthesis|amod|END_ENTITY	Mss51p promotes mitochondrial Cox1p synthesis and interacts with newly synthesized Cox1p .
14592991	0	Mss51p	0,6	Cox1p	83,88	Mss51p	Cox1p	118490	4512	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Mss51p promotes mitochondrial Cox1p synthesis and interacts with newly synthesized Cox1p .
15306853	0	Mss51p	0,6	Cox1p	49,54	Mss51p	Cox1p	850900(Tax:4932)	854598(Tax:4932)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces_cerevisiae .
25074980	0	Mst1	36,40	Rab13	0,5	Mst1	Rab13	15235(Tax:10090)	68328(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking .
21102585	0	Mst1/2	0,6	Yap	21,24	Mst1/2	Yap	4485;6788	10413	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Mst1/2 signalling to Yap : gatekeeper for liver size and tumour development .
19013223	0	Msvop	65,70	synaptic_vesicle-2-associated_protein	26,63	Msvop	synaptic vesicle-2-associated protein	68666(Tax:10090)	734235(Tax:8355)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of mouse synaptic_vesicle-2-associated_protein -LRB- Msvop -RRB- specifically expressed in the mouse central nervous system .
26667042	0	Msx	49,52	muscle_segment_homeobox	24,47	Msx	muscle segment homeobox	17701(Tax:10090)	17701(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Uterine inactivation of muscle_segment_homeobox -LRB- Msx -RRB- genes alters epithelial cell junction proteins during embryo implantation .
23720046	0	Msx1	0,4	Bmp4	40,44	Msx1	Bmp4	17701(Tax:10090)	12159(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development .
10215616	0	Msx1	34,38	CBP/p300	229,237	Msx1	CBP/p300	17701(Tax:10090)	12914;328572	Gene	Gene	gene|amod|START_ENTITY autorepression|nmod|gene mediated|nsubjpass|autorepression mediated|nmod|interactions interactions|nmod|protein protein|appos|END_ENTITY	Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding_protein , Sp1 and cAMP-response-element-binding_protein-binding_protein -LRB- CBP/p300 -RRB- .
10215616	0	Msx1	75,79	CBP/p300	229,237	Msx1	CBP/p300	17701(Tax:10090)	12914;328572	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Transcriptional autorepression of Msx1 gene is mediated by interactions of Msx1 protein with a multi-protein transcriptional complex containing TATA-binding_protein , Sp1 and cAMP-response-element-binding_protein-binding_protein -LRB- CBP/p300 -RRB- .
7538067	0	Msx1	50,54	Hox_7	56,61	Msx1	Hox 7	17701(Tax:10090)	17701(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Digit tip regeneration correlates with regions of Msx1 -LRB- Hox_7 -RRB- expression in fetal and newborn mice .
21420399	0	Msx1	53,57	Osr2	0,4	Msx1	Osr2	17701(Tax:10090)	107587(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field .
18703512	0	Msx2	31,35	BMP2	0,4	Msx2	BMP2	17702(Tax:10090)	12156(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation .
21471203	0	Msx2	87,91	BMP2	63,67	Msx2	BMP2	4488	650	Gene	Gene	gene|amod|START_ENTITY enhances|nmod|gene enhances|dobj|responsiveness responsiveness|appos|END_ENTITY	Notch signaling pathway enhances bone_morphogenetic_protein_2 -LRB- BMP2 -RRB- responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells .
23145080	0	Msx2	103,107	FOXC1	111,116	Msx2	FOXC1	17702(Tax:10090)	17300(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY differentiation|nmod|regulation differentiation|nmod|END_ENTITY	Initiation of early osteoblast differentiation events through the direct transcriptional regulation of Msx2 by FOXC1 .
14512019	0	Msx2	71,75	Foxc1	51,56	Msx2	Foxc1	17702(Tax:10090)	17300(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4 .
23344708	0	Msx2	114,118	Foxc1	0,5	Msx2	Foxc1	17702(Tax:10090)	17300(Tax:10090)	Gene	Gene	threshold|nmod|START_ENTITY regulation|nmod|threshold controls|nmod|regulation controls|nsubj|END_ENTITY	Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2 .
23702391	0	Msx2	38,42	Hairless	0,8	Msx2	Hairless	17702(Tax:10090)	15460(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Hairless down-regulates expression of Msx2 and its related target genes in hair follicles .
15272023	0	Msx2	26,30	MAGE-D1	55,62	Msx2	MAGE-D1	17702(Tax:10090)	94275(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells .
18703512	0	Msx2	31,35	Osterix	15,22	Msx2	Osterix	17702(Tax:10090)	170574(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation .
22457812	0	Msx2	32,36	Progesterone_receptor	0,21	Msx2	Progesterone receptor	4488	5241	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Progesterone_receptor activates Msx2 expression by downregulating TNAP/Akp2 and activating the Bmp pathway in EpH4 mouse mammary epithelial cells .
9819228	0	Msx2	79,83	osteocalcin	25,36	Msx2	osteocalcin	25483(Tax:10116)	81613(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|END_ENTITY	Reciprocal regulation of osteocalcin transcription by the homeodomain proteins Msx2 and Dlx5 .
16583136	0	Msx2-interacting_nuclear_target_protein	17,56	UbcH8	108,113	Msx2-interacting nuclear target protein	UbcH8	23013	9246	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Spen homolog Msx2-interacting_nuclear_target_protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8 .
9535847	0	Mtd	0,3	Bcl-2	13,18	Mtd	Bcl-2	4493	596	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	Mtd , a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL .
9535847	0	Mtd	0,3	Bcl-2	95,100	Mtd	Bcl-2	4493	596	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Mtd , a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL .
26966248	0	Mte1	0,4	Mph1	20,24	Mte1	Mph1	10965	7272	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance .
24980046	0	Mtg16	19,24	Id2	87,90	Mtg16	Id2	863	3398	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2 .
24277933	0	Mth1	64,68	Pph3	40,44	Mth1	Pph3	4521	5531	Gene	Gene	targets|nmod|START_ENTITY targets|dobj|END_ENTITY	Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression .
24277933	0	Mth1	64,68	Psy2	0,4	Mth1	Psy2	4521	57223	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression .
1976815	0	Mto	16,19	Metallothionein	0,15	Mto	Metallothionein	42424(Tax:7227)	42424(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Metallothionein Mto gene of Drosophila_melanogaster : structure and regulation .
11836260	0	Mts1	164,168	Liprin_beta_1	0,13	Mts1	Liprin beta 1	6275	8496	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Liprin_beta_1 , a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins , is a new target for the metastasis-associated_protein_S100A4 -LRB- Mts1 -RRB- .
15101091	0	Mts1	30,34	Metastasis-associated_S100A4	0,28	Mts1	Metastasis-associated S100A4	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Metastasis-associated_S100A4 -LRB- Mts1 -RRB- protein is expressed in subpopulations of sensory and autonomic neurons and in Schwann cells of the adult rat .
11018041	0	Mts1	43,47	S100A4	49,55	Mts1	S100A4	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Oligomeric forms of the metastasis-related Mts1 -LRB- S100A4 -RRB- protein stimulate neuronal differentiation in cultures of rat hippocampal neurons .
16265347	0	Mts1	8,12	S100A4	0,6	Mts1	S100A4	6275	6275	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	S100A4 -LRB- Mts1 -RRB- gene overexpression is associated with invasion and metastasis of papillary_thyroid_carcinoma .
22479308	0	Mtss1	0,5	Rac1	82,86	Mtss1	Rac1	9788	5879	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1 .
17925019	0	Mtss1	106,111	metastasis_suppressor_1	81,104	Mtss1	metastasis suppressor 1	211401(Tax:10090)	211401(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression and differentiation-related neuron-specific splicing of metastasis_suppressor_1 -LRB- Mtss1 -RRB- in normal and transformed cerebellar cells .
8301116	0	Mtv-7	14,19	sag	20,23	Mtv-7	sag	111375(Tax:10090)	20215(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of Mtv-7 sag gene in vivo using a retroviral vector results in selective inactivation of superantigen reactive T cells .
21463018	0	Mu-opioid_receptor	0,18	OPRM1	20,25	Mu-opioid receptor	OPRM1	574141(Tax:9544)	574141(Tax:9544)	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Mu-opioid_receptor -LRB- OPRM1 -RRB- variation , oxytocin levels and maternal attachment in free-ranging rhesus_macaques Macaca_mulatta .
24774073	0	MuRF-1	178,184	mammalian_target_of_rapamycin	58,87	MuRF-1	mammalian target of rapamycin	84676	2475	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	b-Hydroxy-b-methylbutyrate facilitates PI3K/Akt-dependent mammalian_target_of_rapamycin and FoxO1/3a phosphorylations and alleviates tumor_necrosis_factor_a / interferon y-induced MuRF-1 expression in C2C12 cells .
26116825	0	MuRF1	21,26	PPARa	37,42	MuRF1	PPARa	84676	5465	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The ubiquitin ligase MuRF1 regulates PPARa activity in the heart by enhancing nuclear export via monoubiquitination .
19244212	0	MuSK	43,47	Dok-7	0,5	MuSK	Dok-7	4593	285489	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation .
20603078	0	MuSK	76,80	Dok7	32,36	MuSK	Dok7	4593	285489	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The cytoplasmic_adaptor protein Dok7 activates the receptor_tyrosine_kinase MuSK via dimerization .
9136771	0	MuSK	23,27	Rapsyn	0,6	MuSK	Rapsyn	18198(Tax:10090)	19400(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nmod|signaling required|nsubjpass|END_ENTITY	Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold .
1958179	0	Muc1	21,25	episialin	10,19	Muc1	episialin	17829(Tax:10090)	17829(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse episialin -LRB- Muc1 -RRB- gene and its promoter : rapid evolution of the repetitive domain in the protein .
19762846	0	Muc1	7,11	mucin	78,83	Muc1	mucin	281333(Tax:9913)	404104(Tax:9913)	Gene	Gene	gene|nsubj|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	Bovine Muc1 is a highly polymorphic gene encoding an extensively glycosylated mucin that binds bacteria .
11278439	0	Muc13	0,5	mucin	34,39	Muc13	mucin	56667	100508689	Gene	Gene	expressed|advmod|START_ENTITY expressed|nsubj|END_ENTITY	Muc13 , a novel human cell surface mucin expressed by epithelial and hemopoietic cells .
16887038	0	Muc13	81,86	mucin	16,21	Muc13	mucin	100859223	423101(Tax:9031)	Gene	Gene	domain|nmod|START_ENTITY encoded|nsubjpass|domain shows|ccomp|encoded shows|nsubj|inventory inventory|nmod|genes genes|compound|END_ENTITY	An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins .
16887038	0	Muc13	81,86	mucin	65,70	Muc13	mucin	100859223	423101(Tax:9031)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins .
7926500	0	Muc2	37,41	mucin	69,74	Muc2	mucin	4583	100508689	Gene	Gene	mucin|dep|START_ENTITY Biosynthesis|nmod|mucin END_ENTITY|nsubj|Biosynthesis	Biosynthesis of human colonic mucin : Muc2 is the prominent secretory mucin .
16891313	0	Muc4	15,19	ERK	57,60	Muc4	ERK	4585	5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Membrane mucin Muc4 induces density-dependent changes in ERK activation in mammary epithelial and tumor cells : role in reversal of contact inhibition .
15499570	0	Muc4	77,81	ErbB2	42,47	Muc4	ErbB2	303887(Tax:10116)	24337(Tax:10116)	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression , location , and interactions of ErbB2 and its intramembrane ligand Muc4 -LRB- sialomucin_complex -RRB- in rat mammary gland during pregnancy .
17292332	0	Muc4	0,4	ErbB2	35,40	Muc4	ErbB2	4585	2064	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Muc4 is required for activation of ErbB2 in signet ring carcinoma cell lines .
10880365	0	Muc4	85,89	sialomucin	62,72	Muc4	sialomucin	303887(Tax:10116)	295490(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of the 5 ' flanking region of the sialomucin complex/rat Muc4 gene : promoter activity in cultured cells .
9245735	0	Muc5AC	15,21	mucin	22,27	Muc5AC	mucin	682837(Tax:10116)	100508689	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Cloning of rat Muc5AC mucin gene : comparison of its structure and tissue distribution to that of human and mouse homologues .
15361359	0	Muc5ac	28,34	mucin	35,40	Muc5ac	mucin	4586	100508689	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells .
25820562	0	Muc5ac	0,6	mucin	7,12	Muc5ac	mucin	682837(Tax:10116)	100508689	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Muc5ac mucin expression during rat skin development .
9488676	0	MucB	24,28	single_strand_DNA_binding_protein	44,77	MucB	single strand DNA binding protein	3861227(Tax:562)	11027484	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The mutagenesis protein MucB interacts with single_strand_DNA_binding_protein and induces a major conformational change in its complex with single-stranded DNA .
1787340	0	Muc_1	36,41	mucin	24,29	Muc 1	mucin	4582	100508689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the human mucin gene , Muc_1 , in normal tissues and metastatic pancreatic_tumors .
8654717	0	Mucin	0,5	CFTR	62,66	Mucin	CFTR	100508689	1080	Gene	Gene	secretion|compound|START_ENTITY mediated|nsubj|secretion mediated|nmod|protein protein|appos|END_ENTITY	Mucin secretion mediated by the cystic fibrosis gene protein , CFTR .
8443822	0	Mucin	0,5	MUC-1	93,98	Mucin	MUC-1	100508689	4582	Gene	Gene	synthesis|compound|START_ENTITY synthesis|acl:relcl|express express|dobj|gene gene|compound|END_ENTITY	Mucin synthesis and secretion in various human epithelial_cancer cell lines that express the MUC-1 mucin gene .
11724326	0	Mucin	0,5	MUC1	12,16	Mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mucin gene -LRB- MUC1 -RRB- transfer into human dendritic cells by cationic liposomes and recombinant adenovirus .
12439613	0	Mucin	0,5	MUC1	12,16	Mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mucin gene -LRB- MUC1 -RRB- transfected dendritic cells as vaccine : results of a phase I/II clinical trial .
15280401	0	Mucin	0,5	MUC1	80,84	Mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Mucin expression in pleomorphic_adenoma of salivary gland : a potential role for MUC1 as a marker to predict recurrence .
26393683	0	Mucin	23,28	MUC1	18,22	Mucin	MUC1	100508689	4582	Gene	Gene	Counter-Regulates|compound|START_ENTITY Counter-Regulates|compound|END_ENTITY	Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages .
9685530	0	Mucin	0,5	MUC1	23,27	Mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Mucin gene expression -LRB- MUC1 , MUC2 , and MUC5/5AC -RRB- in nasal epithelial cells of cystic_fibrosis , allergic_rhinitis , and normal individuals .
8838089	0	Mucin	1,6	MUC2	45,49	Mucin	MUC2	100508689	4583	Gene	Gene	gene|compound|START_ENTITY gene|dep|regulation regulation|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	-LSB- Mucin gene -- regulation of the expression of MUC2 and MUC3 mucin gene in the airway -RSB- .
11751498	0	Mucin	0,5	MUC4	109,113	Mucin	MUC4	100508689	4585	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Mucin -LRB- MUC -RRB- gene expression in human pancreatic_adenocarcinoma and chronic_pancreatitis : a potential role of MUC4 as a tumor marker of diagnostic significance .
17197898	0	Mucin	0,5	MUC5AC	25,31	Mucin	MUC5AC	100508689	4586	Gene	Gene	genes|compound|START_ENTITY genes|dep|MUC2 MUC2|appos|MUC4 MUC4|nummod|END_ENTITY	Mucin genes -LRB- MUC2 , MUC4 , MUC5AC , and MUC6 -RRB- detection in normal and pathological endometrial tissues .
21254123	0	Mucin	0,5	MUC5AC	7,13	Mucin	MUC5AC	100508689	4586	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mucin -LRB- MUC5AC -RRB- expression by lung epithelial cells cultured in a microfluidic gradient device .
21998660	0	Mucin	0,5	MUC5AC	125,131	Mucin	MUC5AC	100508689	4586	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|dep|association association|nmod|END_ENTITY	Mucin variable number tandem repeat polymorphisms and severity of cystic_fibrosis lung_disease : significant association with MUC5AC .
20802811	0	Mucin	25,30	MUC7	20,24	Mucin	MUC7	100508689	4589	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Regulation of Human MUC7 Mucin Gene Expression by Cigarette Smoke Extract or Cigarette Smoke and Pseudomonas_aeruginosa Lipopolysaccharide in Human Airway Epithelial Cells and in MUC7 Transgenic_Mice .
21195737	0	Mucin	0,5	interleukin-6	56,69	Mucin	interleukin-6	100508689	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Mucin from rheumatoid_arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells .
8443822	0	Mucin	0,5	mucin	99,104	Mucin	mucin	100508689	100508689	Gene	Gene	synthesis|compound|START_ENTITY synthesis|acl:relcl|express express|dobj|gene gene|compound|END_ENTITY	Mucin synthesis and secretion in various human epithelial_cancer cell lines that express the MUC-1 mucin gene .
8838089	0	Mucin	1,6	mucin	59,64	Mucin	mucin	100508689	100508689	Gene	Gene	gene|compound|START_ENTITY gene|dep|regulation regulation|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	-LSB- Mucin gene -- regulation of the expression of MUC2 and MUC3 mucin gene in the airway -RSB- .
21927028	0	Mucin_1	0,7	AKT	68,71	Mucin 1	AKT	4582	207	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Mucin_1 enhances the tumor angiogenic response by activation of the AKT signaling pathway .
26035123	0	Mucin_1	0,7	Cox-2	18,23	Mucin 1	Cox-2	4582	5743	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	Mucin_1 Regulates Cox-2 gene in Pancreatic_Cancer .
1351710	0	Mucin_4	0,7	MUC4	9,13	Mucin 4	MUC4	4585	4585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mucin_4 -LRB- MUC4 -RRB- gene : regional assignment -LRB- 3q29 -RRB- and RFLP analysis .
25239130	0	Mucolipin_1	0,11	TLR7	33,37	Mucolipin 1	TLR9	57192	54106	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|nummod|END_ENTITY	Mucolipin_1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes .
19713937	0	Mule	25,29	ARF-BP1	17,24	Mule	ARF-BP1	10075	10075	Gene	Gene	modulates|nsubj|START_ENTITY END_ENTITY|parataxis|modulates	Ubiquitin ligase ARF-BP1 / Mule modulates base excision repair .
17363596	0	Mullerian-inhibiting_substance	0,30	Gro-beta	39,47	Mullerian-inhibiting substance	Gro-beta	268	2920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Mullerian-inhibiting_substance induces Gro-beta expression in breast_cancer cells through a nuclear_factor-kappaB-dependent and Smad1-dependent mechanism .
19056816	0	Mullerian-inhibiting_substance	79,109	MIS	111,114	Mullerian-inhibiting substance	MIS	268	268	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Interaction of the vitamin_D_receptor with a vitamin_D response element in the Mullerian-inhibiting_substance -LRB- MIS -RRB- promoter : regulation of MIS expression by calcitriol in prostate_cancer cells .
11773638	0	Mullerian-inhibiting_substance	0,30	NF-kappa_B	41,51	Mullerian-inhibiting substance	NF-kappa B	268	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Mullerian-inhibiting_substance regulates NF-kappa_B signaling in the prostate in vitro and in vivo .
9165127	0	Mullerian_Inhibiting_Substance	68,98	SF-1	21,25	Mullerian Inhibiting Substance	SF-1	268	7536	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian_Inhibiting_Substance , in vivo .
8596488	0	Mullerian_inhibiting_substance	75,105	epidermal_growth_factor_receptor	13,45	Mullerian inhibiting substance	epidermal growth factor receptor	268	1956	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Reduction of epidermal_growth_factor_receptor phosphorylation by activated Mullerian_inhibiting_substance is vanadate-sensitive .
21127835	0	Multi_drug_resistance-1	0,23	MDR1	25,29	Multi drug resistance-1	MDR1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Multi_drug_resistance-1 -LRB- MDR1 -RRB- expression in response to chronic diazinon exposure : an in vitro study on Caco-2 cells .
25816099	0	Multidrug_Resistance	31,51	MDR1	53,57	Multidrug Resistance	MDR1	5243	5243	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	The Roles of Variants in Human Multidrug_Resistance -LRB- MDR1 -RRB- Gene and Their Haplotypes on Antiepileptic Drugs Response : A Meta-Analysis of 57 Studies .
26292095	0	Multidrug_Resistance-Associated_Protein_2	30,71	Interleukin-18	0,14	Multidrug Resistance-Associated Protein 2	Interleukin-18	1244	3606	Gene	Gene	START_ENTITY|nsubj|Down-Regulates Down-Regulates|compound|END_ENTITY	Interleukin-18 Down-Regulates Multidrug_Resistance-Associated_Protein_2 Expression through Farnesoid_X_Receptor Associated with Nuclear Factor Kappa B and Yin_Yang_1 in Human Hepatoma HepG2 Cells .
26292095	0	Multidrug_Resistance-Associated_Protein_2	30,71	Interleukin-18	0,14	Multidrug Resistance-Associated Protein 2	Interleukin-18	1244	3606	Gene	Gene	START_ENTITY|nsubj|Down-Regulates Down-Regulates|compound|END_ENTITY	Interleukin-18 Down-Regulates Multidrug_Resistance-Associated_Protein_2 Expression through Farnesoid_X_Receptor Associated with Nuclear Factor Kappa B and Yin_Yang_1 in Human Hepatoma HepG2 Cells .
12167307	0	Multidrug_Resistance_Protein_2	18,48	Mrp2	50,54	Multidrug Resistance Protein 2	Mrp2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of rat Multidrug_Resistance_Protein_2 -LRB- Mrp2 -RRB- in male and female rats during normal and pregnenolone-16alpha-carbonitrile -LRB- PCN -RRB- - induced postnatal ontogeny .
25896592	0	Multidrug_Resistance_Protein_2	14,44	mrp2	46,50	Multidrug Resistance Protein 2	mrp2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Multidrug_Resistance_Protein_2 -LRB- mrp2 -RRB- in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy .
8709631	0	Multidrug_resistance-1	0,22	MDR1	24,28	Multidrug resistance-1	MDR1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Multidrug_resistance-1 -LRB- MDR1 -RRB- expression and functional dye/drug efflux is highly correlated with the t -LRB- 8 ; 21 -RRB- chromosomal translocation in pediatric acute_myeloid_leukemia .
10533474	0	Multidrug_resistance-associated_protein	0,39	MRP	41,44	Multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Multidrug_resistance-associated_protein -LRB- MRP -RRB- expression is correlated with expression of aberrant p53 protein in colorectal_cancer .
8712746	0	Multidrug_resistance-associated_protein	0,39	MRP	41,44	Multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multidrug_resistance-associated_protein -LRB- MRP -RRB- gene expression in human lung_cancer .
15810950	0	Multidrug_resistance-associated_protein	0,39	MRP1	41,45	Multidrug resistance-associated protein	MRP1	4363	4363	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multidrug_resistance-associated_protein -LRB- MRP1 -RRB- gene is strongly expressed in gastric_carcinomas .
19857663	0	Multidrug_resistance-associated_protein_2	0,41	ABCC2	48,53	Multidrug resistance-associated protein 2	ABCC2	1244	1244	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multidrug_resistance-associated_protein_2 gene -LRB- ABCC2 -RRB- variant in kidney allograft recipients .
9192801	0	Multidrug_resistance_protein	0,28	MRP	30,33	Multidrug resistance protein	MRP	4363	4363	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Multidrug_resistance_protein -LRB- MRP -RRB- expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein .
23503867	0	Multidrug_resistance_protein_4	0,30	MRP4	32,36	Multidrug resistance protein 4	MRP4	10257	10257	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Multidrug_resistance_protein_4 -LRB- MRP4 -RRB- expression in prostate_cancer is associated with androgen signaling and decreases with tumor progression .
16951149	0	Multiple_endocrine_neoplasia_type_1	0,35	CHES1	81,86	Multiple endocrine neoplasia type 1	CHES1	4221	1112	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Multiple_endocrine_neoplasia_type_1 interacts with forkhead transcription factor CHES1 in DNA damage response .
12729799	0	Multiprotein_bridging_factor_1	0,30	c-Jun	47,52	Multiprotein bridging factor 1	c-Jun	8721	3725	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Multiprotein_bridging_factor_1 cooperates with c-Jun and is necessary for cardiac_hypertrophy in vitro .
14744865	0	Munc-18-1	0,9	phospholipase_D	19,34	Munc-18-1	phospholipase D	6812	2822	Gene	Gene	inhibits|compound|START_ENTITY END_ENTITY|nsubj|inhibits	Munc-18-1 inhibits phospholipase_D activity by direct interaction in an epidermal_growth_factor-reversible manner .
19812333	0	Munc13-1	153,161	CAST	102,106	Munc13-1	CAST	23025	831	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	A protein interaction node at the neurotransmitter release site : domains of Aczonin/Piccolo , Bassoon , CAST , and rim converge on the N-terminal domain of Munc13-1 .
26680738	0	Munc13-4	0,8	syntaxin_7	24,34	Munc13-4	syntaxin 7	201294	8417	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Munc13-4 interacts with syntaxin_7 , regulates late endosomal maturation , endosomal signaling and TLR9-initiated cellular responses .
15869823	0	Munc18-1	24,32	p67	34,37	Munc18-1	p67	25558(Tax:10116)	25558(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Nuclear localization of Munc18-1 -LRB- p67 -RRB- in the adult rat brain and PC12 cells .
10788461	0	Munc18-2	0,8	syntaxin_3	34,44	Munc18-2	syntaxin 3	6813	6809	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Munc18-2 , a functional partner of syntaxin_3 , controls apical membrane trafficking in epithelial cells .
21444687	0	Munc18c	0,7	insulin_receptor	31,47	Munc18c	insulin receptor	6814	3643	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Munc18c phosphorylation by the insulin_receptor links cell signaling directly to SNARE exocytosis .
17324928	0	Munc18c	129,136	protein_kinase_C_alpha	87,109	Munc18c	protein kinase C alpha	6814	5578	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein_kinase_C_alpha phosphorylation of Munc18c .
9168999	0	Munc18c	54,61	syntaxin_4	40,50	Munc18c	syntaxin 4	6814	6810	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the binding of SNAP-23 to syntaxin_4 by Munc18c .
19308274	0	Murine_Double_Minute_2	18,40	MDM2	42,46	Murine Double Minute 2	MDM2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	The Expression of Murine_Double_Minute_2 -LRB- MDM2 -RRB- on Helicobacter_pylori-Infected Intestinal_Metaplasia and Gastric_Cancer .
25782991	0	Musashi-1	20,29	Msi2	47,51	Musashi-1	Msi2	17690(Tax:10090)	76626(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus .
26639245	0	Musashi-2	31,40	MSI2	42,46	Musashi-2	MSI2	124540	124540	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prognostic significance of the Musashi-2 -LRB- MSI2 -RRB- gene in childhood acute_lymphoblastic_leukemia .
26373800	0	Musashi_1	24,33	tachykinin_1	54,66	Musashi 1	tachykinin 1	17690(Tax:10090)	21333(Tax:10090)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|amod|END_ENTITY	The RNA-binding protein Musashi_1 stabilizes the onco tachykinin_1 mRNA in breast_cancer cells to promote cell growth .
21084860	0	Musashi_2	57,66	Numb	67,71	Musashi 2	Numb	124540	8650	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Aggressive myeloid_leukemia formation is directed by the Musashi_2 / Numb pathway .
11927605	0	Muscle-specific_RING_finger-1	0,29	titin	45,50	Muscle-specific RING finger-1	titin	84676	7273	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Muscle-specific_RING_finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid_modulatory_element_binding_protein-1 .
19752190	0	Muscle_LIM_protein	0,18	cofilin_2	34,43	Muscle LIM protein	cofilin 2	8048	1073	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Muscle_LIM_protein interacts with cofilin_2 and regulates F-actin dynamics in cardiac_and_skeletal_muscle .
26492373	0	Muscle_Lim_Protein	0,18	CSRP3	25,30	Muscle Lim Protein	CSRP3	8048	8048	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Muscle_Lim_Protein -LRB- MLP -RRB- / CSRP3 at the crossroad between mechanotransduction and autophagy .
9724633	0	Muskelin	0,8	thrombospondin-1	88,104	Muskelin	thrombospondin-1	36386(Tax:7227)	21825(Tax:10090)	Gene	Gene	START_ENTITY|appos|mediator mediator|nmod|END_ENTITY	Muskelin , a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1 .
18635600	0	MutS_homolog_2	8,22	MSH2	24,28	MutS homolog 2	MSH2	4436	4436	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of MutS_homolog_2 -LRB- MSH2 -RRB- in intestinal myofibroblast proliferation during Crohn 's _ disease stricture formation .
23143036	0	MutS_homolog_2	109,123	MSH2	125,129	MutS homolog 2	MSH2	406845(Tax:7955)	406845(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cadmium -LRB- Cd -RRB- - induced oxidative stress down-regulates the gene expression of DNA mismatch recognition proteins MutS_homolog_2 -LRB- MSH2 -RRB- and MSH6 in zebrafish -LRB- Danio_rerio -RRB- embryos .
21078976	0	MutS_homolog_2	78,92	MicroRNA-21	0,11	MutS homolog 2	MicroRNA-21	4436	406991	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS_homolog_2 -LRB- hMSH2 -RRB- .
11801590	0	MutS_homolog_2	146,160	MutS_homolog_6	167,181	MutS homolog 2	MutS homolog 6	4436	2956	Gene	Gene	START_ENTITY|acl|/ /|dobj|END_ENTITY	Human MutY homolog , a DNA glycosylase involved in base excision repair , physically and functionally interacts with mismatch repair proteins human MutS_homolog_2 / human MutS_homolog_6 .
8950986	0	MutS_homolog_2	20,34	hMSH2	36,41	MutS homolog 2	hMSH2	4436	4436	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human MutS_homolog_2 -LRB- hMSH2 -RRB- protein in resting and proliferating cells .
10556423	0	MutS_homolog_5	49,63	Msh5	65,69	MutS homolog 5	Msh5	17687(Tax:10090)	17687(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification and characterization of the mouse MutS_homolog_5 : Msh5 .
20696460	0	MutS_homolog_6	98,112	MSH6	114,118	MutS homolog 6	MSH6	260437(Tax:7955)	260437(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Sublethal levels of cadmium down-regulate the gene expression of DNA mismatch recognition protein MutS_homolog_6 -LRB- MSH6 -RRB- in zebrafish -LRB- Danio_rerio -RRB- embryos .
11801590	0	MutS_homolog_6	167,181	MutS_homolog_2	146,160	MutS homolog 6	MutS homolog 2	2956	4436	Gene	Gene	/|dobj|START_ENTITY END_ENTITY|acl|/	Human MutY homolog , a DNA glycosylase involved in base excision repair , physically and functionally interacts with mismatch repair proteins human MutS_homolog_2 / human MutS_homolog_6 .
10213463	0	MxA	48,51	IFN-alpha	160,169	MxA	IFN-alpha	4599	3440	Gene	Gene	mRNA|compound|START_ENTITY Correlation|nmod|mRNA Correlation|nmod|response response|nmod|patients patients|nmod|therapy therapy|amod|chronic_active_hepatitis_C chronic_active_hepatitis_C|nmod|END_ENTITY	Correlation of interferon-induced expression of MxA mRNA in peripheral blood mononuclear cells with the response of patients with chronic_active_hepatitis_C to IFN-alpha therapy .
17892402	0	MxA	0,3	IFN-alpha	93,102	MxA	IFN-alpha	4599	3440	Gene	Gene	induction|compound|START_ENTITY predict|nsubj|induction predict|nmod|treatment treatment|amod|END_ENTITY	MxA induction may predict sustained virologic responses of chronic_hepatitis_B patients with IFN-alpha treatment .
7540146	0	MxA	18,21	IFN-alpha	0,9	MxA	IFN-alpha	4599	3439	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IFN-alpha induces MxA gene expression in cultured human corneal fibroblasts .
12936994	0	MxA	59,62	PKR	97,100	MxA	PKR	4599	5610	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Antiviral effects of geranylgeranylacetone : enhancement of MxA expression and phosphorylation of PKR during influenza_virus_infection .
22008548	0	Mxi1	0,4	insulin-like_growth_factor_binding_protein-3	42,86	Mxi1	insulin-like growth factor binding protein-3	17859(Tax:10090)	16009(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Mxi1 regulates cell proliferation through insulin-like_growth_factor_binding_protein-3 .
17255949	0	Mxi2	0,4	ERK	35,38	Mxi2	ERK	1432	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|translocation translocation|compound|END_ENTITY	Mxi2 promotes stimulus-independent ERK nuclear translocation .
11403721	0	MyD118	85,91	Gadd45beta	93,103	MyD118	Gadd45beta	17873(Tax:10090)	17873(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 -LRB- Gadd45beta -RRB- gene .
10828065	0	MyD118	20,26	PCNA	76,80	MyD118	PCNA	4616	5111	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of MyD118 , Gadd45 , and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- interacting domains .
15890643	0	MyD88	108,113	Akt	247,250	MyD88	Akt	301059(Tax:10116)	24185(Tax:10116)	Gene	Gene	receptor-associated|amod|START_ENTITY cells|nmod|receptor-associated expression|nmod|cells expression|dep|factor factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
18772134	0	MyD88	0,5	Beclin_1	22,30	MyD88	Beclin 1	4615	8678	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	MyD88 and Trif target Beclin_1 to trigger autophagy in macrophages .
21536801	0	MyD88	19,24	CD300F	0,6	MyD88	CD300F	4615	146722	Gene	Gene	blocks|xcomp|START_ENTITY blocks|nsubj|END_ENTITY	CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1 .
22043923	0	MyD88	46,51	CD300a	0,6	MyD88	CD300a	4615	11314	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines .
18209086	0	MyD88	39,44	CD4	62,65	MyD88	CD4	17874(Tax:10090)	12504(Tax:10090)	Gene	Gene	myeloid_differentiation_factor_88|appos|START_ENTITY required|nsubjpass|myeloid_differentiation_factor_88 required|nmod|function function|compound|END_ENTITY	The myeloid_differentiation_factor_88 -LRB- MyD88 -RRB- is required for CD4 + T cell effector function in a murine model of inflammatory_bowel_disease .
19052080	0	MyD88	0,5	CD4	30,33	MyD88	CD4	4615	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	MyD88 intrinsically regulates CD4 T-cell responses .
21498664	0	MyD88	19,24	CD4	59,62	MyD88	CD4	17874(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY shape|nsubj|signaling shape|dobj|response response|compound|END_ENTITY	TLR4 signaling via MyD88 and TRIF differentially shape the CD4 + T cell response to Porphyromonas_gingivalis_hemagglutinin_B .
23526822	0	MyD88	0,5	CD4	19,22	MyD88	CD4	17874(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	MyD88 signaling in CD4 T cells promotes IFN-y production and hematopoietic progenitor cell expansion in response to intracellular bacterial_infection .
24038087	0	MyD88	26,31	CD4	0,3	MyD88	CD4	4615	920	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	CD4 + T cell expression of MyD88 is essential for normal resolution of Chlamydia_muridarum_genital_tract_infection .
24439266	0	MyD88	39,44	CD4	48,51	MyD88	CD4	17874(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Signaling through the adaptor molecule MyD88 in CD4 + T cells is required to overcome suppression by regulatory T cells .
19414781	0	MyD88	21,26	CD8	45,48	MyD88	CD8	4615	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|responses responses|compound|END_ENTITY	The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia_virus .
20639876	0	MyD88	120,125	Cbl-b	139,144	MyD88	Cbl-b	17874(Tax:10090)	208650(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b .
17227910	0	MyD88	63,68	IL-27_p28	14,23	MyD88	IL-27 p28	17874(Tax:10090)	246779(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-27_p28 gene expression in macrophages through MyD88 - and interferon-gamma-mediated pathways .
7567467	0	MyD88	25,30	IL-6	35,39	MyD88	IL-6	301059(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	5 ' upstream sequences of MyD88 , an IL-6 primary response gene in M1 cells : detection of functional IRF-1 and Stat factors binding sites .
11254583	0	MyD88	45,50	IRAK	53,57	MyD88	IRAK	4615	3654	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
11254583	0	MyD88	45,50	NF-kappaB	79,88	MyD88	NF-kappaB	4615	4790	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
18070982	0	MyD88	29,34	NF-kappaB	69,78	MyD88	NF-kappaB	4615	4790	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	TRAF6 distinctively mediates MyD88 - and IRAK-1-induced activation of NF-kappaB .
11254583	0	MyD88	45,50	NIK	67,70	MyD88	NIK	4615	9020	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
18571728	0	MyD88	39,44	PTP1B	12,17	MyD88	PTP1B	4615	5770	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Phosphatase PTP1B negatively regulates MyD88 - and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages .
19955209	0	MyD88	20,25	PYK2	0,4	MyD88	PYK2	4615	2185	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PYK2 interacts with MyD88 and regulates MyD88-mediated NF-kappaB activation in macrophages .
18566426	0	MyD88	0,5	TLR4	55,59	MyD88	TLR4	17874(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY dependent|nsubj|regulation dependent|nmod|END_ENTITY	MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2 .
19506249	0	MyD88	54,59	TLR4	74,78	MyD88	TLR4	4615	7099	Gene	Gene	domain|compound|START_ENTITY interactions|nmod|domain basis|nmod|interactions basis|nmod|signaling signaling|compound|END_ENTITY	Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling .
21498664	0	MyD88	19,24	TLR4	0,4	MyD88	TLR4	17874(Tax:10090)	21898(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	TLR4 signaling via MyD88 and TRIF differentially shape the CD4 + T cell response to Porphyromonas_gingivalis_hemagglutinin_B .
21897371	0	MyD88	86,91	TLR4	95,99	MyD88	TLR4	4615	7099	Gene	Gene	START_ENTITY|nmod|signalling signalling|compound|END_ENTITY	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-b1-induced degradation of MyD88 in TLR4 signalling .
22394636	0	MyD88	42,47	TLR4	36,40	MyD88	TLR4	17874(Tax:10090)	21898(Tax:10090)	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression and significance of TLR4 , MyD88 and NF-kB mRNA in mouse lymph node of experimental autoimmune_myositis -RSB- .
22474023	0	MyD88	84,89	TLR4	34,38	MyD88	TLR4	4615	7099	Gene	Gene	recruitment|nmod|START_ENTITY interfering|nmod|recruitment signaling|advcl|interfering END_ENTITY|acl|signaling	The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF .
22788664	0	MyD88	42,47	TLR4	36,40	MyD88	TLR4	4615	7099	Gene	Gene	NF-kappaB|dep|START_ENTITY NF-kappaB|nummod|END_ENTITY	LPS induces IL-8 expression through TLR4 , MyD88 , NF-kappaB and MAPK pathways in human dental pulp stem cells .
23716300	0	MyD88	0,5	TLR4	94,98	MyD88	TLR4	17874(Tax:10090)	21898(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY required|nsubjpass|interaction required|nmod|adjuvant adjuvant|compound|END_ENTITY	MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant .
26043978	0	MyD88	150,155	TLR4	63,67	MyD88	TLR4	4615	7099	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression responsiveness|acl:relcl|associated responsiveness|nummod|END_ENTITY	Bovine_viral_diarrhea_virus_type_2 in vivo infection modulates TLR4 responsiveness in differentiated myeloid cells which is associated with decreased MyD88 expression .
26175492	0	MyD88	68,73	TLR4	99,103	MyD88	TLR4	4615	7099	Gene	Gene	pathways|compound|START_ENTITY conferred|nmod|pathways conferred|nmod|activation activation|compound|END_ENTITY	Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation .
19638630	0	MyD88	86,91	Th2	26,29	MyD88	Th2	17874(Tax:10090)	15111(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM .
19602669	0	MyD88	121,126	Toll-like_receptor_2	72,92	MyD88	Toll-like receptor 2	17874(Tax:10090)	24088(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|nmod|involvement	Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like_receptor_2 with partial involvement of MyD88 .
22051147	0	MyD88	21,26	Toll-like_receptor_2	0,20	MyD88	Toll-like receptor 2	17874(Tax:10090)	24088(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Toll-like_receptor_2 / MyD88 signaling mediates zymosan-induced joint hypernociception in mice : participation of TNF-a , IL-1b and CXCL1/KC .
23826757	0	MyD88	130,135	Toll-like_receptor_2	2,22	MyD88	Toll-like receptor 2	17874(Tax:10090)	24088(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY production|nmod|association augments|dobj|production augments|nsubj|ligand ligand|compound|END_ENTITY	A Toll-like_receptor_2 ligand , Pam3CSK4 , augments interferon-y-induced nitric_oxide production via a physical association between MyD88 and interferon-y receptor in vascular endothelial cells .
15890643	0	MyD88	108,113	c-Jun_N-terminal_kinase	252,275	MyD88	c-Jun N-terminal kinase	301059(Tax:10116)	116554(Tax:10116)	Gene	Gene	receptor-associated|amod|START_ENTITY cells|nmod|receptor-associated expression|nmod|cells expression|dep|factor factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
15890643	0	MyD88	108,113	c-Src	209,214	MyD88	c-Src	301059(Tax:10116)	83805(Tax:10116)	Gene	Gene	receptor-associated|amod|START_ENTITY cells|nmod|receptor-associated expression|nmod|cells expression|dep|factor factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
26806747	0	MyD88	21,26	miR-21	48,54	MyD88	miR-21	4615	406991	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|END_ENTITY	-LSB- Modulation of TLR-4 / MyD88 signaling cascade by miR-21 is involved in airway immunologic_dysfunction induced by cold air exposure -RSB- .
15890643	0	MyD88	108,113	phosphatidylinositol_3-kinase	216,245	MyD88	phosphatidylinositol 3-kinase	301059(Tax:10116)	298947(Tax:10116)	Gene	Gene	receptor-associated|amod|START_ENTITY cells|nmod|receptor-associated expression|nmod|cells expression|dep|factor factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
16644730	0	MyD88	8,13	phosphatidylinositol_3-kinase	17,46	MyD88	phosphatidylinositol 3-kinase	4615	5293	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Role of MyD88 in phosphatidylinositol_3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells .
18458086	0	MyD88	13,18	protein_kinase_Cepsilon	34,57	MyD88	protein kinase Cepsilon	17874(Tax:10090)	18754(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The scaffold MyD88 acts to couple protein_kinase_Cepsilon to Toll-like receptors .
14977922	0	MyD88	8,13	tumor_necrosis_factor_alpha	28,55	MyD88	tumor necrosis factor alpha	4615	7124	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Role of MyD88 in diminished tumor_necrosis_factor_alpha production by newborn mononuclear cells in response to lipopolysaccharide .
10707845	0	MyHC	34,38	myosin_heavy_chain	14,32	MyHC	myosin heavy chain	29605(Tax:10116)	29605(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of myosin_heavy_chain -LRB- MyHC -RRB- isoforms in rat intrafusal muscle fibres after neonatal deefferentation and subsequent denervation .
22993210	0	MyRIP	0,5	MyoVa	23,28	MyRIP	MyoVa	25924	4644	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway .
12351189	0	MyT1	50,54	NZF-2	44,49	MyT1	NZF-2	17932(Tax:10090)	17932(Tax:10090)	Gene	Gene	START_ENTITY|dep|form form|nmod|END_ENTITY	NZF-2b is a novel predominant form of mouse NZF-2 / MyT1 , expressed in differentiated neurons especially at higher levels in newly generated ones .
8654374	0	Myb	41,44	CBP	32,35	Myb	CBP	4602	1387	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Interaction of the co-activator CBP with Myb proteins : effects on Myb-specific transactivation and on the cooperativity with NF-M .
8420994	0	Myb	41,44	cdc2	21,25	Myb	cdc2	4602	983	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	c-myb transactivates cdc2 expression via Myb binding sites in the 5 ' - flanking region of the human cdc2 gene .
8420994	0	Myb	41,44	cdc2	98,102	Myb	cdc2	4602	983	Gene	Gene	expression|nmod|START_ENTITY transactivates|dobj|expression transactivates|nsubj|sites sites|nmod|5 5|dep|region region|nmod|gene gene|amod|END_ENTITY	c-myb transactivates cdc2 expression via Myb binding sites in the 5 ' - flanking region of the human cdc2 gene .
11545594	0	Myb	27,30	hRap1	21,26	Myb	hRap1	4602	54386	Gene	Gene	motif|compound|START_ENTITY motif|amod|END_ENTITY	NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains .
25543088	0	Myb-binding_protein_1A	27,49	MYBBP1A	51,58	Myb-binding protein 1A	MYBBP1A	10514	10514	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation and function of Myb-binding_protein_1A -LRB- MYBBP1A -RRB- in cellular senescence and pathogenesis of head_and_neck_cancer .
24948530	0	Myb14	0,5	STS	29,32	Myb14	STS	817674(Tax:3702)	828186(Tax:3702)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Myb14 , a direct activator of STS , is associated with resveratrol content variation in berry skin in two grape cultivars .
23318434	0	Myc	19,22	Abl	26,29	Myc	Abl	4609	25	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dual regulation of Myc by Abl .
10380878	0	Myc	33,36	Bin1	0,4	Myc	Bin1	4609	274	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms .
10412034	0	Myc	121,124	Bin1	107,111	Myc	Bin1	4609	274	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1 , a novel Myc interacting protein .
9151695	0	Myc	64,67	Carcinoembryonic_antigen	0,24	Myc	Carcinoembryonic antigen	4609	1084	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Carcinoembryonic_antigen , a human tumor marker , cooperates with Myc and Bcl-2 in cellular transformation .
22186139	0	Myc	0,3	HIF1	34,38	Myc	HIF1	4609	3091	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|compound|END_ENTITY	Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells .
16269333	0	Myc	68,71	HectH9	21,27	Myc	HectH9	4609	10075	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation .
11439337	0	Myc	0,3	Max	53,56	Myc	Max	24577(Tax:10116)	60661(Tax:10116)	Gene	Gene	drives|compound|START_ENTITY apoptosis|nsubj|drives apoptosis|nmod|cells cells|nmod|absence absence|nmod|END_ENTITY	Myc drives apoptosis in PC12 cells in the absence of Max .
12695332	0	Myc	34,37	Max	39,42	Myc	Max	31310(Tax:7227)	40095(Tax:7227)	Gene	Gene	network|compound|START_ENTITY network|appos|END_ENTITY	Genomic binding by the Drosophila Myc , Max , Mad/Mnt transcription factor network .
12747840	0	Myc	12,15	Max	70,73	Myc	Max	4609	4149	Gene	Gene	Analysis|nmod|START_ENTITY shows|nsubj|Analysis shows|ccomp|essential essential|nsubj|END_ENTITY	Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression .
1459463	0	Myc	26,29	Max	19,22	Myc	Max	4609	4149	Gene	Gene	activity|compound|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Biphasic effect of Max on Myc cotransformation activity and dependence on amino - and carboxy-terminal Max functions .
1644290	0	Myc	0,3	Max	118,121	Myc	Max	4609	4149	Gene	Gene	oncoproteins|compound|START_ENTITY function|nsubj|oncoproteins function|xcomp|transform transform|dobj|cells cells|amod|cross-interference cross-interference|nmod|END_ENTITY	Myc family oncoproteins function through a common pathway to transform normal cells in culture : cross-interference by Max and trans-acting dominant mutants .
19498040	0	Myc	80,83	Max	19,22	Myc	Max	4609	4149	Gene	Gene	function|nsubj|START_ENTITY inhibit|ccomp|function inhibit|nsubj|Stabilizers Stabilizers|nmod|homodimer homodimer|compound|END_ENTITY	Stabilizers of the Max homodimer identified in virtual ligand screening inhibit Myc function .
19887915	0	Myc	0,3	Max	26,29	Myc	Max	4609	4149	Gene	Gene	life|nsubj|START_ENTITY life|nmod|END_ENTITY	Myc 's secret life without Max .
2006410	0	Myc	95,98	Max	0,3	Myc	Max	4609	4149	Gene	Gene	forms|nmod|START_ENTITY protein|acl:relcl|forms END_ENTITY|dep|protein	Max : a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc .
20426839	0	Myc	0,3	Max	19,22	Myc	Max	4609	4149	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Myc interacts with Max and Miz1 to repress C/EBPdelta promoter activity and gene expression .
7630640	0	Myc	74,77	Max	96,99	Myc	Max	24577(Tax:10116)	60661(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY responsible|nmod|regulation sequences|amod|responsible Determination|nmod|sequences function|nsubj|Determination function|nmod|END_ENTITY	Determination of sequences responsible for the differential regulation of Myc function by delta Max and Max .
8417337	0	Myc	48,51	Max	70,73	Myc	Max	4609	4149	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Sequence-specific transcriptional activation by Myc and repression by Max .
8425218	0	Myc	54,57	Max	33,36	Myc	Max	4609	4149	Gene	Gene	activity|compound|START_ENTITY antagonizes|dobj|activity partner|acl:relcl|antagonizes partner|nmod|END_ENTITY	Mad : a heterodimeric partner for Max that antagonizes Myc transcriptional activity .
19001505	0	Myc	0,3	Miz-1	62,67	Myc	Miz-1	4609	7709	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Myc increases self-renewal in neural progenitor cells through Miz-1 .
16391002	0	Myc	0,3	Miz1	83,87	Myc	Miz1	4609	7709	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1 .
26766587	0	Myc	19,22	Miz1	28,32	Myc	Miz1	4609	7709	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|Identity Identity|compound|END_ENTITY	The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity .
24951594	0	Myc	21,24	Myc	39,42	Myc	Myc	4609	4609	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Sin3b interacts with Myc and decreases Myc levels .
24951594	0	Myc	39,42	Myc	21,24	Myc	Myc	4609	4609	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Sin3b interacts with Myc and decreases Myc levels .
18455888	0	Myc	46,49	NDRG1	35,40	Myc	NDRG1	4609	10397	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region .
20598117	0	Myc	0,3	Nfkb2	19,24	Myc	Nfkb2	4609	4791	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	Myc suppression of Nfkb2 accelerates lymphomagenesis .
16751266	0	Myc	0,3	Notch1	9,15	Myc	Notch1	17869(Tax:10090)	18128(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary_tumorigenesis in mice .
21803744	0	Myc	67,70	Notch1	10,16	Myc	Notch1	17869(Tax:10090)	18128(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung_adenocarcinoma .
15735755	0	Myc	19,22	PML	0,3	Myc	PML	4609	5371	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PML interacts with Myc , and Myc target gene expression is altered in PML-null fibroblasts .
26943576	0	Myc	81,84	Pin1	0,4	Myc	Pin1	17869(Tax:10090)	23988(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc .
21558421	0	Myc	42,45	Romo1	0,5	Myc	Romo1	4609	140823	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Romo1 is a negative-feedback regulator of Myc .
15743832	0	Myc	42,45	TEL2	21,25	Myc	TEL2	4609	51513	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis .
22328504	0	Myc	21,24	TRIM6	0,5	Myc	TRIM6	17869(Tax:10090)	94088(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells .
25870263	0	Myc	65,68	TXNIP	84,89	Myc	TXNIP	4609	10628	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	Metabolic reprogramming in triple-negative breast_cancer through Myc suppression of TXNIP .
23665319	0	Myc	0,3	Utf1	34,38	Myc	Utf1	17869(Tax:10090)	22286(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain .
12706874	0	Myc	14,17	Yaf2	0,4	Myc	Yaf2	4609	10138	Gene	Gene	function|compound|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Yaf2 inhibits Myc biological function .
19143767	0	Myc	0,3	cdk4	38,42	Myc	cdk4	4609	1019	Gene	Gene	down-regulation|compound|START_ENTITY affects|nsubj|down-regulation affects|dobj|activity activity|amod|END_ENTITY	Myc down-regulation affects cyclin_D1 / cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line .
19143767	0	Myc	0,3	cyclin_D1	28,37	Myc	cyclin D1	4609	595	Gene	Gene	down-regulation|compound|START_ENTITY affects|nsubj|down-regulation affects|dobj|activity activity|amod|END_ENTITY	Myc down-regulation affects cyclin_D1 / cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line .
7478619	0	Myc	51,54	cyclin_D1	14,23	Myc	cyclin D1	24577(Tax:10116)	58919(Tax:10116)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|Expression Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of cyclin_D1 mRNA is not upregulated by Myc in rat fibroblasts .
7526316	0	Myc	0,3	cyclin_D1	12,21	Myc	cyclin D1	24577(Tax:10116)	58919(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Myc induces cyclin_D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle .
9244353	0	Myc	131,134	cyclin_D1	77,86	Myc	cyclin D1	4609	595	Gene	Gene	CDK4|nmod|START_ENTITY requirement|dep|CDK4 requirement|dep|evidence evidence|nmod|END_ENTITY	Mutual requirement of CDK4 and Myc in malignant transformation : evidence for cyclin_D1 / CDK4 and p16INK4A as upstream regulators of Myc .
9190899	0	Myc	0,3	gadd45	37,43	Myc	gadd45	4609	1647	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Myc represses the growth_arrest gene gadd45 .
26528759	0	Myc	0,3	glutaminase_2	80,93	Myc	glutaminase 2	4609	27165	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase_2 .
22002311	0	Myc	0,3	miR-15a	14,21	Myc	miR-15a	4609	406948	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Myc represses miR-15a / miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell_lymphomas .
22002311	0	Myc	0,3	miR-16-1	22,30	Myc	miR-16-1	4609	406950	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Myc represses miR-15a / miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell_lymphomas .
10606642	0	Myc	0,3	nucleolin	16,25	Myc	nucleolin	4609	4691	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Myc induces the nucleolin and BN51 genes : possible implications in ribosome biogenesis .
8146655	0	Myc	31,34	p107	72,76	Myc	p107	4609	5933	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Binding and suppression of the Myc transcriptional activation domain by p107 .
16410719	0	Myc	31,34	p14ARF	0,6	Myc	p14ARF	4609	1029	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	p14ARF directly interacts with Myc through the Myc BoxII domain .
16410719	0	Myc	47,50	p14ARF	0,6	Myc	p14ARF	4609	1029	Gene	Gene	domain|compound|START_ENTITY interacts|nmod|domain interacts|nsubj|END_ENTITY	p14ARF directly interacts with Myc through the Myc BoxII domain .
11283613	0	Myc	37,40	p15INK4b	14,22	Myc	p15INK4b	17869(Tax:10090)	12579(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of p15INK4b expression by Myc through association with Miz-1 .
12545156	0	Myc	0,3	p21CIP1	38,45	Myc	p21CIP1	4609	1026	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter .
25528767	0	Myc	36,39	p32	14,17	Myc	p32	4609	3622	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Mitochondrial p32 is upregulated in Myc expressing brain_cancers and mediates glutamine addiction .
18413597	0	Myc	63,66	p400	23,27	Myc	p400	4609	57634	Gene	Gene	induce|dobj|START_ENTITY END_ENTITY|xcomp|induce	Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc .
12902982	0	Myc	0,3	p53	20,23	Myc	p53	4609	7157	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts .
22446994	0	Myc	49,52	p53	32,35	Myc	p53	17869(Tax:10090)	22060(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY END_ENTITY|nmod|mice	Potential synergism of Bim with p53 in mice with Myc - induced lymphoma in a mouse_lymphoma model .
19623543	0	Myc	25,28	retinoic_acid_receptor_beta	32,59	Myc	retinoic acid receptor beta	4609	5915	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of Myc on retinoic_acid_receptor_beta and PDLIM4 in RWPE1 cells .
15094381	0	Myc-associated_zinc_finger_protein	38,72	RAG-2	20,25	Myc-associated zinc finger protein	RAG-2	17188(Tax:10090)	19374(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|promoter promoter|compound|END_ENTITY	Activation of mouse RAG-2 promoter by Myc-associated_zinc_finger_protein .
18955045	0	MycN	37,41	CRABP-II	14,22	MycN	CRABP-II	4613	1382	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of CRABP-II expression by MycN in Wilms_tumor .
16912187	0	MycN	80,84	Cellular_retinoic_acid-binding_protein_II	0,41	MycN	Cellular retinoic acid-binding protein II	4613	1382	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cellular_retinoic_acid-binding_protein_II is a direct transcriptional target of MycN in neuroblastoma .
25426416	0	MycN	0,4	TRPM7	14,19	MycN	TRPM7	4613	54822	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines .
11593398	0	MycN	58,62	Yaf2	26,30	MycN	Yaf2	4613	10138	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of Yaf2 with the central region of MycN .
19724862	0	MycN	0,4	livin	39,44	MycN	livin	4613	79444	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	MycN is a transcriptional regulator of livin in neuroblastoma .
23525682	0	Mycbp2	24,30	Robo2	58,63	Mycbp2	Robo2	105689(Tax:10090)	268902(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system .
21530945	0	Myd88	67,72	myeloid_differentiation_primary_response_protein_88	14,65	Myd88	myeloid differentiation primary response protein 88	301059(Tax:10116)	301059(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of myeloid_differentiation_primary_response_protein_88 -LRB- Myd88 -RRB- in the cerebral cortex after experimental traumatic_brain_injury in rats .
23186691	0	Myd88	85,90	myeloid_differentiation_primary_response_protein_88	32,83	Myd88	myeloid differentiation primary response protein 88	4615	4615	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced cortical expression of myeloid_differentiation_primary_response_protein_88 -LRB- Myd88 -RRB- in patients with traumatic_brain_injury .
12089450	0	Myelin-associated_glycoprotein	0,30	Nogo-66_receptor	62,78	Myelin-associated glycoprotein	Nogo-66 receptor	4099	65078	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Myelin-associated_glycoprotein as a functional ligand for the Nogo-66_receptor .
12160746	0	Myelin-associated_glycoprotein	0,30	Nogo66_receptor	50,65	Myelin-associated glycoprotein	Nogo66 receptor	4099	65078	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Myelin-associated_glycoprotein interacts with the Nogo66_receptor to inhibit neurite outgrowth .
6200496	0	Myelin-associated_glycoprotein	0,30	myelin_basic_protein	50,70	Myelin-associated glycoprotein	myelin basic protein	611884(Tax:9615)	476160(Tax:9615)	Gene	Gene	produced|nsubjpass|START_ENTITY produced|nmod|END_ENTITY	Myelin-associated_glycoprotein is produced before myelin_basic_protein in cultured oligodendrocytes .
25697841	0	Myelin_Basic_Protein	0,20	AbPP	37,41	Myelin Basic Protein	AbPP	4155	351	Gene	Gene	Associates|compound|START_ENTITY Associates|nmod|END_ENTITY	Myelin_Basic_Protein Associates with AbPP , Ab1-42 , and Amyloid_Plaques in Cortex of Alzheimer 's _ Disease Brain .
24878628	0	Myelin_and_Lymphocyte_Protein	26,55	MAL	57,60	Myelin and Lymphocyte Protein	MAL	25263(Tax:10116)	25263(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	The Expression Changes of Myelin_and_Lymphocyte_Protein -LRB- MAL -RRB- Following Optic Nerve Crush in Adult Rats Retinal Ganglion Cells .
1693693	0	Myelin_basic_protein	0,20	calmodulin	39,49	Myelin basic protein	calmodulin	100344447(Tax:9986)	100352392(Tax:9986)	Gene	Gene	START_ENTITY|dep|interaction interaction|nmod|END_ENTITY	Myelin_basic_protein : interaction with calmodulin and gangliosides .
11746786	0	Myelin_basic_protein	0,20	heme_oxygenase-1	29,45	Myelin basic protein	heme oxygenase-1	4155	3162	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Myelin_basic_protein induces heme_oxygenase-1 in human astroglial cells .
6208068	0	Myelin_basic_protein	0,20	quaking	40,47	Myelin basic protein	quaking	17196(Tax:10090)	19317(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Myelin_basic_protein gene expression in quaking , jimpy , and myelin_synthesis-deficient mice .
15274043	0	Myelin_oligodendrocyte_glycoprotein	0,35	MOG	37,40	Myelin oligodendrocyte glycoprotein	MOG	4340	4340	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- gene is associated with obsessive-compulsive_disorder .
17330875	0	Myelin_transcription_factor_1	0,29	Myt1	31,35	Myelin transcription factor 1	Myt1	4661	4661	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Myelin_transcription_factor_1 -LRB- Myt1 -RRB- expression in demyelinated lesions of rodent and human CNS .
26878343	0	Myeloid_Cell_Leukemia_1	38,61	Mcl-1	63,68	Myeloid Cell Leukemia 1	Mcl-1	4170	4170	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of 2-Indole-acylsulfonamide Myeloid_Cell_Leukemia_1 -LRB- Mcl-1 -RRB- Inhibitors Using Fragment-Based Methods .
23216940	0	Myeloid_cell_leukemia-1	0,23	HIF-1	90,95	Myeloid cell leukemia-1	HIF-1	4170	3091	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Myeloid_cell_leukemia-1 -LRB- Mc1-1 -RRB- is a candidate target gene of hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- in the testis .
15861129	0	Myeloid_leukemia_factor_1	0,25	p53	36,39	Myeloid leukemia factor 1	p53	4291	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Myeloid_leukemia_factor_1 regulates p53 by suppressing COP1 via COP9_signalosome_subunit_3 .
23776465	0	Myeloma_overexpressed_2	0,23	L11	43,46	Myeloma overexpressed 2	L11	150678	6135	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nummod|END_ENTITY	Myeloma_overexpressed_2 -LRB- Myeov2 -RRB- regulates L11 subnuclear localization through Nedd8 modification .
7691248	0	Myeloperoxidase	0,15	CD34	30,34	Myeloperoxidase	CD34	4353	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Myeloperoxidase expression in CD34 + normal human hematopoietic cells .
2835725	0	Myeloperoxidase	0,15	GM-CSF	43,49	Myeloperoxidase	GM-CSF	4353	1437	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Myeloperoxidase and oncogene expression in GM-CSF induced bone marrow differentiation .
22219194	0	Myeloperoxidase	0,15	apolipoprotein_A-I	24,42	Myeloperoxidase	apolipoprotein A-I	4353	335	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Myeloperoxidase targets apolipoprotein_A-I , the major high density lipoprotein protein , for site-specific oxidation in human atherosclerotic_lesions .
17591979	0	Myeloperoxidase	0,15	cytokeratin_1	56,69	Myeloperoxidase	cytokeratin 1	4353	3848	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Myeloperoxidase interacts with endothelial cell-surface cytokeratin_1 and modulates bradykinin production by the plasma Kallikrein-Kinin system .
24417960	0	Myeloperoxidase	0,15	endothelin_receptor_type_B	28,54	Myeloperoxidase	endothelin receptor type B	4353	1910	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Myeloperoxidase upregulates endothelin_receptor_type_B expression .
8626014	0	Myf-5	70,75	Myf-6	10,15	Myf-5	Myf-6	17877(Tax:10090)	17878(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Myf-5 -LRB- m1 -RRB- / Myf-6 -LRB- m1 -RRB- compound heterozygous mouse mutants down-regulate Myf-5 expression and exert rib_defects : evidence for long-range cis effects on Myf-5 transcription .
8626014	0	Myf-6	10,15	Myf-5	70,75	Myf-6	Myf-5	17878(Tax:10090)	17877(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Myf-5 -LRB- m1 -RRB- / Myf-6 -LRB- m1 -RRB- compound heterozygous mouse mutants down-regulate Myf-5 expression and exert rib_defects : evidence for long-range cis effects on Myf-5 transcription .
15497153	0	Myf5	139,143	MyoD	149,153	Myf5	MyoD	4617	4654	Gene	Gene	esophagus|nmod|START_ENTITY transdifferentiation|nmod|esophagus neurotrophins|nmod|transdifferentiation involvement|nmod|neurotrophins Evidence|nmod|involvement Evidence|dep|END_ENTITY	Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5 -LRB- - / - -RRB- : MyoD -LRB- - / - -RRB- and NT-3 -LRB- - / - -RRB- embryos .
15844178	0	Myf5	133,137	MyoD	141,145	Myf5	MyoD	17877(Tax:10090)	17927(Tax:10090)	Gene	Gene	revealed|nmod|START_ENTITY revealed|dep|/ /|parataxis|END_ENTITY	Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation , as revealed in Myf5 - / - : MyoD - / - embryos .
16179075	0	Myf5	124,128	MyoD	38,42	Myf5	MyoD	281335(Tax:9913)	281938(Tax:9913)	Gene	Gene	alteration|nmod|START_ENTITY Effect|dep|alteration Effect|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	Effect of phase limited inhibition of MyoD expression on the terminal differentiation of bovine myoblasts : no alteration of Myf5 or myogenin expression .
16208536	0	Myf5	0,4	MyoD	9,13	Myf5	MyoD	17877(Tax:10090)	17927(Tax:10090)	Gene	Gene	START_ENTITY|dep|/ /|parataxis|END_ENTITY	Myf5 - / - : MyoD - / - amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis .
17330803	0	Myf5	23,27	MyoD	31,35	Myf5	MyoD	17877(Tax:10090)	17927(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Microarray analysis of Myf5 - / - : MyoD - / - hypoplastic mouse lungs reveals a profile of genes involved in pneumocyte differentiation .
9658178	0	Myf5	99,103	MyoD	76,80	Myf5	MyoD	17877(Tax:10090)	17927(Tax:10090)	Gene	Gene	affecting|dobj|START_ENTITY selectively|advcl|affecting selectively|dobj|expression expression|nmod|END_ENTITY	RhoA GTPase and serum_response_factor control selectively the expression of MyoD without affecting Myf5 in mouse myoblasts .
15386014	0	Myf5	44,48	Myod	49,53	Myf5	Myod	17877(Tax:10090)	17927(Tax:10090)	Gene	Gene	identity|nmod|START_ENTITY determines|dobj|identity determines|dep|mice mice|compound|END_ENTITY	Mrf4 determines skeletal muscle identity in Myf5 : Myod double-mutant mice .
9216993	0	Myf5	28,32	Myogenin	0,8	Myf5	Myogenin	17877(Tax:10090)	17928(Tax:10090)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently .
21211521	0	Myf5	28,32	Zic1	11,15	Myf5	Zic1	17877(Tax:10090)	22771(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis .
10694423	0	Myf5	11,15	myogenin	60,68	Myf5	myogenin	17877(Tax:10090)	17928(Tax:10090)	Gene	Gene	Failure|nmod|START_ENTITY Failure|acl|support support|nmod|END_ENTITY	Failure of Myf5 to support myogenic differentiation without myogenin , MyoD , and MRF4 .
8058986	0	Myo	22,25	myoglobin	11,20	Myo	myoglobin	4151	4151	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	-LSB- Levels of myoglobin -LRB- Myo -RRB- in blood of patients during an early phase after kidney transplantation -RSB- .
21971746	0	Myo-inositol-1-phosphate_synthase	41,74	MIPS	76,80	Myo-inositol-1-phosphate synthase	MIPS	542841(Tax:4565)	542841(Tax:4565)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression analysis of a heat-inducible , Myo-inositol-1-phosphate_synthase -LRB- MIPS -RRB- gene from wheat and the alternatively spliced variants of rice and Arabidopsis .
22661706	0	Myo10	54,59	Myo10	9,14	Myo10	Myo10	17909(Tax:10090)	17909(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons .
22661706	0	Myo10	9,14	Myo10	54,59	Myo10	Myo10	17909(Tax:10090)	17909(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Headless Myo10 is a negative regulator of full-length Myo10 and inhibits axon outgrowth in cortical neurons .
15582604	0	Myo18A	49,55	MysPDZ	41,47	Myo18A	MysPDZ	399687	399687	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Subcellular localization and dynamics of MysPDZ -LRB- Myo18A -RRB- in live mammalian cells .
16678774	0	Myo2p	98,103	Inp2p	33,38	Myo2p	Inp2p	854504(Tax:4932)	855198(Tax:4932)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces_cerevisiae .
18316399	0	MyoD	28,32	Beta-catenin	0,12	MyoD	Beta-catenin	4654	1499	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Beta-catenin interacts with MyoD and regulates its transcription activity .
20956306	0	MyoD	25,29	CLOCK	0,5	MyoD	CLOCK	17927(Tax:10090)	12753(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function .
20940258	0	MyoD	22,26	CLP-1	0,5	MyoD	CLP-1	17927(Tax:10090)	98985(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	CLP-1 associates with MyoD and HDAC to restore skeletal muscle cell regeneration .
14585496	0	MyoD	93,97	EID-2	0,5	MyoD	EID-2	4654	163126	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	EID-2 , a novel member of the EID family of p300-binding proteins inhibits transactivation by MyoD .
17389685	0	MyoD	11,15	FHL3	0,4	MyoD	FHL3	17927(Tax:10090)	14201(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	FHL3 binds MyoD and negatively regulates myotube formation .
26492245	0	MyoD	0,4	FIT1	37,41	MyoD	FIT1	4654	161247	Gene	Gene	Activator|nsubj|START_ENTITY Activator|nmod|Gene Gene|compound|END_ENTITY	MyoD Is a Novel Activator of Porcine FIT1 Gene by Interacting with the Canonical E-Box Element during Myogenesis .
17506979	0	MyoD	28,32	Foxc2	0,5	MyoD	Foxc2	17927(Tax:10090)	14234(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Foxc2 induces expression of MyoD and differentiation of the mouse myoblast cell line C2C12 .
17030984	0	MyoD	0,4	Fstl1	14,19	MyoD	Fstl1	4654	11167	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206 .
25839232	0	MyoD	109,113	H2A.Z	31,36	MyoD	H2A.Z	17927(Tax:10090)	51788(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Expression Expression|nmod|END_ENTITY	Expression of Non-acetylatable H2A.Z in Myoblast Cells Blocks Myoblast Differentiation through Disruption of MyoD Expression .
2300571	0	MyoD	33,37	Herculin	0,8	MyoD	Herculin	17927(Tax:10090)	17878(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Herculin , a fourth member of the MyoD family of myogenic regulatory genes .
20235117	0	MyoD	43,47	Id1	52,55	MyoD	Id1	4654	3397	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Affinity of synthetic peptide fragments of MyoD for Id1 protein and their biological effects in several cancer cells .
24123584	0	MyoD	56,60	Id1	84,87	MyoD	Id1	4654	3397	Gene	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Structure activity relationships of peptidic analogs of MyoD for the development of Id1 inhibitors as antiproliferative agents .
24814716	0	MyoD	61,65	Irxl1	34,39	MyoD	Irxl1	17927(Tax:10090)	210719(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The homeobox transcription factor Irxl1 negatively regulates MyoD expression and myoblast differentiation .
25534856	0	MyoD	45,49	KDM4B	24,29	MyoD	KDM4B	17927(Tax:10090)	193796(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The histone demethylase KDM4B interacts with MyoD to regulate myogenic differentiation in C2C12 myoblast cells .
24361185	0	MyoD	23,27	Kbtbd5	0,6	MyoD	Kbtbd5	4654	131377	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage .
21454680	0	MyoD	60,64	Mitogen-activated_protein_kinase_kinase_1	0,41	MyoD	Mitogen-activated protein kinase kinase 1	4654	5604	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Mitogen-activated_protein_kinase_kinase_1 -LRB- MEK1 -RRB- stabilizes MyoD through direct phosphorylation at tyrosine 156 during myogenic differentiation .
10561505	0	MyoD	0,4	Mos	14,17	MyoD	Mos	4654	4342	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	MyoD binds to Mos and inhibits the Mos/MAP kinase pathway .
9001211	0	MyoD	74,78	Mos	0,3	MyoD	Mos	17927(Tax:10090)	24559(Tax:10116)	Gene	Gene	proteins|compound|START_ENTITY heterodimerization|nmod|proteins promoting|dobj|heterodimerization activates|advcl|promoting activates|nsubj|END_ENTITY	Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins .
15497153	0	MyoD	149,153	Myf5	139,143	MyoD	Myf5	4654	4617	Gene	Gene	Evidence|dep|START_ENTITY Evidence|nmod|involvement involvement|nmod|neurotrophins neurotrophins|nmod|transdifferentiation transdifferentiation|nmod|esophagus esophagus|nmod|END_ENTITY	Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5 -LRB- - / - -RRB- : MyoD -LRB- - / - -RRB- and NT-3 -LRB- - / - -RRB- embryos .
15844178	0	MyoD	141,145	Myf5	133,137	MyoD	Myf5	17927(Tax:10090)	17877(Tax:10090)	Gene	Gene	/|parataxis|START_ENTITY revealed|dep|/ revealed|nmod|END_ENTITY	Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation , as revealed in Myf5 - / - : MyoD - / - embryos .
16179075	0	MyoD	38,42	Myf5	124,128	MyoD	Myf5	281938(Tax:9913)	281335(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression Effect|nmod|inhibition Effect|dep|alteration alteration|nmod|END_ENTITY	Effect of phase limited inhibition of MyoD expression on the terminal differentiation of bovine myoblasts : no alteration of Myf5 or myogenin expression .
16208536	0	MyoD	9,13	Myf5	0,4	MyoD	Myf5	17927(Tax:10090)	17877(Tax:10090)	Gene	Gene	/|parataxis|START_ENTITY END_ENTITY|dep|/	Myf5 - / - : MyoD - / - amyogenic fetuses reveal the importance of early contraction and static loading by striated muscle in mouse skeletogenesis .
17330803	0	MyoD	31,35	Myf5	23,27	MyoD	Myf5	17927(Tax:10090)	17877(Tax:10090)	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Microarray analysis of Myf5 - / - : MyoD - / - hypoplastic mouse lungs reveals a profile of genes involved in pneumocyte differentiation .
9658178	0	MyoD	76,80	Myf5	99,103	MyoD	Myf5	17927(Tax:10090)	17877(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY selectively|dobj|expression selectively|advcl|affecting affecting|dobj|END_ENTITY	RhoA GTPase and serum_response_factor control selectively the expression of MyoD without affecting Myf5 in mouse myoblasts .
10406466	0	MyoD	96,100	N-CoR	33,38	MyoD	N-CoR	4654	9611	Gene	Gene	interacts|nmod|START_ENTITY regulates|parataxis|interacts regulates|nsubj|END_ENTITY	The nuclear_receptor_corepressor N-CoR regulates differentiation : N-CoR directly interacts with MyoD .
10406466	0	MyoD	96,100	N-CoR	66,71	MyoD	N-CoR	4654	9611	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The nuclear_receptor_corepressor N-CoR regulates differentiation : N-CoR directly interacts with MyoD .
26944559	0	MyoD	0,4	PPARy	22,27	MyoD	PPARy	4654	5468	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	MyoD promotes porcine PPARy gene expression through an E-box and a MyoD-binding site in the PPARy promoter region .
9094722	0	MyoD	24,28	Pax-3	8,13	MyoD	Pax-3	4654	5077	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue .
10066785	0	MyoD	57,61	RBP-J	42,47	MyoD	RBP-J	17927(Tax:10090)	19664(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis .
23840772	0	MyoD	15,19	Six1	0,4	MyoD	Six1	17927(Tax:10090)	20471(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Six1 regulates MyoD expression in adult muscle progenitor cells .
12023284	0	MyoD	37,41	Slug	0,4	MyoD	Slug	17927(Tax:10090)	20583(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Slug is a novel downstream target of MyoD .
9547268	0	MyoD	79,83	TFIIB	115,120	MyoD	TFIIB	4654	2959	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|association association|nmod|END_ENTITY	TFIID -LRB- TBP -RRB- stabilizes the binding of MyoD to its DNA site at the promoter and MyoD facilitates the association of TFIIB with the preinitiation complex .
18047787	0	MyoD	85,89	UCP2	62,66	MyoD	UCP2	17927(Tax:10090)	22228(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of the promoter activity of the mouse UCP2 and UCP3 genes by MyoD and myogenin .
8076204	0	MyoD	76,80	myf-5	45,50	MyoD	myf-5	17927(Tax:10090)	17877(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Expression of myogenic factors in the mouse : myf-5 , the first member of the MyoD gene family to be transcribed during skeletal myogenesis .
19267618	0	MyoD	39,43	myogenin	18,26	MyoD	myogenin	17927(Tax:10090)	17928(Tax:10090)	Gene	Gene	not|nmod|START_ENTITY expression|dep|not expression|nmod|END_ENTITY	The expression of myogenin , but not of MyoD , is temperature-sensitive in mouse skeletal muscle cells .
19567095	0	MyoD	1,5	myotonic_dystrophy	58,76	MyoD	myotonic dystrophy	4654	1760	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- MyoD mRNA expression in skeletal muscle of patients with myotonic_dystrophy -RSB- .
10944526	0	MyoD	36,40	p300	21,25	MyoD	p300	4654	2033	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	CREB-binding_protein / p300 activates MyoD by acetylation .
11463815	0	MyoD	31,35	p300	70,74	MyoD	p300	4654	2033	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between acetylated MyoD and the bromodomain of CBP and/or p300 .
14517256	0	MyoD	93,97	p300	21,25	MyoD	p300	17927(Tax:10090)	328572(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY role|dep|acts role|nmod|acetyltransferase acetyltransferase|amod|END_ENTITY	Differential role of p300 and CBP acetyltransferase during myogenesis : p300 acts upstream of MyoD and Myf5 .
14517256	0	MyoD	93,97	p300	71,75	MyoD	p300	17927(Tax:10090)	328572(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nummod|END_ENTITY	Differential role of p300 and CBP acetyltransferase during myogenesis : p300 acts upstream of MyoD and Myf5 .
8621548	0	MyoD	65,69	p300	6,10	MyoD	p300	4654	2033	Gene	Gene	coactivator|nmod|START_ENTITY coactivator|nsubj|protein protein|amod|END_ENTITY	Human p300 protein is a coactivator for the transcription factor MyoD .
9001254	0	MyoD	104,108	p300	49,53	MyoD	p300	4654	2033	Gene	Gene	domain|nmod|START_ENTITY interaction|nmod|domain mechanisms|dep|interaction mechanisms|nmod|coactivation coactivation|nmod|END_ENTITY	Molecular mechanisms of myogenic coactivation by p300 : direct interaction with the activation domain of MyoD and with the MADS box of MEF2C .
9826778	0	MyoD	99,103	p300	149,153	MyoD	p300	17927(Tax:10090)	328572(Tax:10090)	Gene	Gene	function|compound|START_ENTITY regulation|nmod|function inhibits|nmod|regulation inhibits|parataxis|interacts interacts|nmod|END_ENTITY	The orphan nuclear receptor , COUP-TF_II , inhibits myogenesis by post-transcriptional regulation of MyoD function : COUP-TF_II directly interacts with p300 and myoD .
15254975	0	MyoD	0,4	p57Kip2	31,38	MyoD	p57Kip2	4654	1028	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	MyoD induces the expression of p57Kip2 in cells lacking p21Cip1/Waf1 : overlapping and distinct functions of the two cdk inhibitors .
16405903	0	MyoD	22,26	p57Kip2	0,7	MyoD	p57Kip2	4654	1028	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	p57Kip2 is induced by MyoD through a p73-dependent pathway .
22740650	0	MyoD	0,4	p57kip2	15,22	MyoD	p57kip2	4654	1028	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure .
7970718	0	MyoD	0,4	retinoblastoma	13,27	MyoD	retinoblastoma	4654	5925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	MyoD induces retinoblastoma gene expression during myogenic differentiation .
20956524	0	MyoD	49,53	selenoprotein_W	30,45	MyoD	selenoprotein W	17927(Tax:10090)	20364(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of selenoprotein_W by MyoD during early skeletal muscle differentiation .
21968728	0	MyoD1	104,109	myogenic_determination_1	78,102	MyoD1	myogenic determination 1	281938(Tax:9913)	281938(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of an association between a single nucleotide polymorphism in the bovine myogenic_determination_1 -LRB- MyoD1 -RRB- gene and meat quality traits in indigenous Chinese cattle breeds .
22106411	0	MyoG	97,101	Protein_tyrosine_phosphatase-like_A	0,35	MyoG	Protein tyrosine phosphatase-like A	4656	9200	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Protein_tyrosine_phosphatase-like_A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway .
20634288	0	MyoGEF	21,27	GIPC1	0,5	MyoGEF	GIPC1	55200	10755	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GIPC1 interacts with MyoGEF and promotes MDA-MB-231_breast_cancer cell invasion .
23515721	0	MyoR	46,50	BMP-7	61,66	MyoR	BMP-7	17681(Tax:10090)	12162(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Basic helix-loop-helix transcriptional factor MyoR regulates BMP-7 in acute_kidney_injury .
22996691	0	Myocardin	0,9	BMP10	20,25	Myocardin	BMP10	93649	27302	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Myocardin regulates BMP10 expression and is required for heart development .
22899851	0	Myocardin-like_protein_2	0,24	TGFb	35,39	Myocardin-like protein 2	TGFb	57496	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Myocardin-like_protein_2 regulates TGFb signaling in embryonic stem cells and the developing vasculature .
25381249	0	Myocardin-related_Transcription_Factor_A	71,111	Arginyltransferase_1	14,34	Myocardin-related Transcription Factor A	Arginyltransferase 1	57591	11101	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|Activity Activity|compound|END_ENTITY	Inhibition of Arginyltransferase_1 Induces Transcriptional Activity of Myocardin-related_Transcription_Factor_A -LRB- MRTF-A -RRB- and Promotes Directional Migration .
22185759	0	Myocardin-related_transcription_factor_A	0,40	Bok	65,68	Myocardin-related transcription factor A	Bok	57591	666	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Myocardin-related_transcription_factor_A regulates expression of Bok and Noxa and is involved in apoptotic signalling .
25955164	0	Myocardin_Related_Transcription_Factor-A	10,50	MRTF-A	52,58	Myocardin Related Transcription Factor-A	MRTF-A	223701(Tax:10090)	223701(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	A Role of Myocardin_Related_Transcription_Factor-A -LRB- MRTF-A -RRB- in Scleroderma Related Fibrosis .
18949272	0	Myocyte-specific_enhancer_binding_factor_2C	0,43	MEF2C	45,50	Myocyte-specific enhancer binding factor 2C	MEF2C	499497(Tax:10116)	499497(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Myocyte-specific_enhancer_binding_factor_2C -LRB- MEF2C -RRB- expression in the dentate gyrus during development and after pilocarpine-induced status_epilepticus : a preliminary report .
26355845	0	Myocyte_Enhancer_Factor_2D	9,35	miR-1244	0,8	Myocyte Enhancer Factor 2D	miR-1244	4209	100302285	Gene	Gene	Loop|compound|START_ENTITY Loop|amod|END_ENTITY	miR-1244 / Myocyte_Enhancer_Factor_2D Regulatory Loop Contributes to the Growth_of_Lung_Carcinoma .
18718538	0	Myocyte_enhancer_factor_2	0,25	ColQ	112,116	Myocyte enhancer factor 2	ColQ	4205	8292	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Myocyte_enhancer_factor_2 mediates acetylcholine-induced expression of acetylcholinesterase-associated collagen ColQ in cultured myotubes .
22484155	0	Myocyte_enhancer_factor_2	0,25	MEF2	27,31	Myocyte enhancer factor 2	MEF2	4205	4205	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- tethering to muscle selective A-kinase anchoring protein -LRB- mAKAP -RRB- is necessary for myogenic differentiation .
22484155	0	Myocyte_enhancer_factor_2	0,25	mAKAP	91,96	Myocyte enhancer factor 2	mAKAP	4205	11640(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- tethering to muscle selective A-kinase anchoring protein -LRB- mAKAP -RRB- is necessary for myogenic differentiation .
10781804	0	Myocyte_enhancer_factor_2C	0,26	MASH-1	39,45	Myocyte enhancer factor 2C	MASH-1	17260(Tax:10090)	17172(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Myocyte_enhancer_factor_2C upregulates MASH-1 expression and induces neurogenesis in P19 cells .
15386014	0	Myod	49,53	Myf5	44,48	Myod	Myf5	17927(Tax:10090)	17877(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY determines|dep|mice determines|dobj|identity identity|nmod|END_ENTITY	Mrf4 determines skeletal muscle identity in Myf5 : Myod double-mutant mice .
17702744	0	Myoferlin	0,9	vascular_endothelial_growth_factor	20,54	Myoferlin	vascular endothelial growth factor	226101(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Myoferlin regulates vascular_endothelial_growth_factor receptor-2 stability and function .
16632198	0	Myofibrillogenesis_regulator_1	0,30	MR-1	37,41	Myofibrillogenesis regulator 1	MR-1	25953	25953	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Myofibrillogenesis_regulator_1 gene -LRB- MR-1 -RRB- mutation in an Omani family with paroxysmal nonkinesigenic dyskinesia .
1656214	0	Myogenin	0,8	MEF-2	62,67	Myogenin	MEF-2	17928(Tax:10090)	17260(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products .
9216993	0	Myogenin	0,8	Myf5	28,32	Myogenin	Myf5	17928(Tax:10090)	17877(Tax:10090)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	Myogenin can substitute for Myf5 in promoting myogenesis but less efficiently .
26899964	0	Myoglobin	28,37	S100b	0,5	Myoglobin	S100b	4151	6285	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	S100b induces expression of Myoglobin in APb treated neuronal cells in vitro : a possible neuroprotective mechanism .
12665503	0	Myoglobin	0,9	iNOS	67,71	Myoglobin	iNOS	17189(Tax:10090)	18126(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Myoglobin protects the heart from inducible_nitric-oxide_synthase -LRB- iNOS -RRB- - mediated nitrosative stress .
17046827	0	Myomaxin	0,8	MEF2A	46,51	Myomaxin	MEF2A	241431(Tax:10090)	17258(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein .
11696420	0	Myopodin	0,8	synaptopodin	12,24	Myopodin	synaptopodin	171024	11346	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	Myopodin , a synaptopodin homologue , is frequently deleted in invasive prostate_cancers .
10090768	0	Myosin	47,53	ATPase	103,109	Myosin	ATPase	79784	1769	Gene	Gene	affinity|nmod:poss|START_ENTITY affects|dobj|affinity affects|nmod|cycle cycle|compound|END_ENTITY	The sequence of the myosin 50-20K loop affects Myosin 's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity .
124738	0	Myosin	0,6	ATPase	7,13	Myosin	ATPase	79784	1769	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Myosin ATPase activity in multifidus muscle from cases of lumbar spinal derangement .
22064235	0	Myosin	0,6	ATPase	91,97	Myosin	ATPase	79784	1769	Gene	Gene	composition|amod|START_ENTITY influences|nsubj|composition influences|dobj|susceptibility susceptibility|nmod|END_ENTITY	Myosin heavy chain isoform composition influences the susceptibility of actin-activated S1 ATPase and myofibrillar ATPase to pH inactivation .
6213431	0	Myosin	0,6	ATPase	37,43	Myosin	ATPase	79784	1769	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|activity activity|amod|END_ENTITY	Myosin phosphorylation regulates the ATPase activity of permeable skeletal muscle fibers .
10484331	0	Myosin	0,6	NKCC1	21,26	Myosin	NKCC1	79784	6558	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Myosin regulation of NKCC1 : effects on cAMP-mediated Cl - secretion in intestinal epithelia .
19421144	0	Myosin-interacting_guanine_exchange_factor	0,42	RhoA	140,144	Myosin-interacting guanine exchange factor	RhoA	55200	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Myosin-interacting_guanine_exchange_factor -LRB- MyoGEF -RRB- regulates the invasion activity of MDA-MB-231 breast_cancer cells through activation of RhoA and RhoC .
25686036	0	Myosin_Heavy_Chain	38,56	Akirin2	18,25	Myosin Heavy Chain	Akirin2	396711(Tax:9823)	100519991	Gene	Gene	Expression|compound|START_ENTITY Effect|nmod|Expression Effect|nmod|END_ENTITY	Effect of Porcine Akirin2 on Skeletal Myosin_Heavy_Chain Isoform Expression .
22510086	0	Myosin_Ia	0,9	CFTR	26,30	Myosin Ia	CFTR	432516(Tax:10090)	12638(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|trafficking trafficking|amod|END_ENTITY	Myosin_Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine .
25236597	0	Myosin_VIIA	0,11	Cad99C	76,82	Myosin VIIA	Cad99C	34882(Tax:7227)	43528(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Myosin_VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis .
21740491	0	Myosin_Va	0,9	Rab27a	31,37	Myosin Va	Rab27a	4644	5873	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	Myosin_Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand_factor release from endothelial cells .
25456499	0	Myosin_Va	44,53	TAO1/2	27,33	Myosin Va	TAO1/2	4644	57551;9344	Gene	Gene	Function|compound|START_ENTITY END_ENTITY|nmod|Function	MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin_Va Function in Promoting Spine Synapse Development .
24892806	0	Myosin_Vb	0,9	RAB8A	26,31	Myosin Vb	RAB8A	4645	4218	Gene	Gene	START_ENTITY|acl|uncoupling uncoupling|nmod|elicits elicits|compound|END_ENTITY	Myosin_Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease .
12393859	0	Myosin_Vb	51,60	Rab11_family_interacting_protein_2	0,34	Myosin Vb	Rab11 family interacting protein 2	480220(Tax:9615)	477834(Tax:9615)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Rab11_family_interacting_protein_2 associates with Myosin_Vb and regulates plasma membrane recycling .
17507647	0	Myosin_Vb	0,9	Rab8a	25,30	Myosin Vb	Rab8a	4645	4218	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Myosin_Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3 .
12732190	0	Myosin_light_chain_kinase	0,25	myosin	51,57	Myosin light chain kinase	myosin	4638	79784	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Myosin_light_chain_kinase stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin_light_chain .
24520376	0	Myosin_light_chain_kinase	0,25	tumor_necrosis_factor_receptor_2	49,81	Myosin light chain kinase	tumor necrosis factor receptor 2	4638	7133	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Myosin_light_chain_kinase expression induced via tumor_necrosis_factor_receptor_2 signaling in the epithelial cells regulates the development of colitis-associated_carcinogenesis .
16407236	0	Myospryn	0,8	MEF2A	48,53	Myospryn	MEF2A	76469(Tax:10090)	17258(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle , alpha-actinin-interacting , costamere-localized protein .
16110473	0	Myostatin	0,9	ARA70	80,85	Myostatin	ARA70	17700(Tax:10090)	27057(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Myostatin negatively regulates the expression of the steroid receptor co-factor ARA70 .
18852073	0	Myostatin	0,9	GDF-8	11,16	Myostatin	GDF-8	17700(Tax:10090)	17700(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Myostatin -LRB- GDF-8 -RRB- deficiency increases fracture callus size , Sox-5 expression , and callus bone volume .
20438504	0	Myostatin	0,9	IGF-2	29,34	Myostatin	IGF-2	281187(Tax:9913)	281240(Tax:9913)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle .
17949710	0	Myostatin	0,9	Pax7	26,30	Myostatin	Pax7	17700(Tax:10090)	18509(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Myostatin signals through Pax7 to regulate satellite cell self-renewal .
12209887	0	Myostatin	55,64	Titin-cap	0,9	Myostatin	Titin-cap	2660	8557	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Titin-cap associates with , and regulates secretion of , Myostatin .
17130121	0	Myostatin	0,9	cyclin_D1	18,27	Myostatin	cyclin D1	17700(Tax:10090)	12443(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Myostatin induces cyclin_D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK -3 _ beta pathway and is antagonized by insulin-like_growth_factor_1 .
24906930	0	Myostatin	0,9	glucose_transporter-4	17,38	Myostatin	glucose transporter-4	281187(Tax:9913)	282359(Tax:9913)	Gene	Gene	alters|nsubj|START_ENTITY alters|dobj|expression expression|amod|END_ENTITY	Myostatin alters glucose_transporter-4 -LRB- GLUT4 -RRB- expression in bovine skeletal muscles and myoblasts isolated from double-muscled -LRB- DM -RRB- and normal-muscled -LRB- NM -RRB- Japanese shorthorn cattle .
19903317	0	Myostatin	0,9	myostatin	87,96	Myostatin	myostatin	2660	2660	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Myostatin expression during human muscle hypertrophy and subsequent atrophy : increased myostatin with detraining .
18472397	0	Myostatin	0,9	p300	18,22	Myostatin	p300	2660	2033	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Myostatin induces p300 degradation to silence cyclin_D1 expression through the PI3K/PTEN/Akt pathway .
16674563	0	Myotilin	0,8	vocal_cord_and_pharyngeal_weakness_with_distal_myopathy	39,94	Myotilin	vocal cord and pharyngeal weakness with distal myopathy	9499	9782	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Myotilin is not the causative gene for vocal_cord_and_pharyngeal_weakness_with_distal_myopathy -LRB- VCPDM -RRB- .
21667249	0	Myotrophin	80,90	MTPN	92,96	Myotrophin	MTPN	100521697	100521697	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization , expression patterns and subcellular localization of Myotrophin -LRB- MTPN -RRB- gene in porcine skeletal muscle .
11171996	0	Myozenin	0,8	alpha-actinin	13,26	Myozenin	alpha-actinin	58529	87	Gene	Gene	START_ENTITY|dep|protein protein|amod|END_ENTITY	Myozenin : an alpha-actinin - and gamma-filamin-binding protein of skeletal muscle Z lines .
15582604	0	MysPDZ	41,47	Myo18A	49,55	MysPDZ	Myo18A	399687	399687	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Subcellular localization and dynamics of MysPDZ -LRB- Myo18A -RRB- in live mammalian cells .
23241949	0	Myt1	17,21	MEK1	0,4	Myt1	MEK1	4661	5604	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells .
11959823	0	Myt1	59,63	Mos	15,18	Myt1	Mos	397982(Tax:8355)	397924(Tax:8355)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A new role for Mos in Xenopus oocyte maturation : targeting Myt1 independently of MAPK .
17330875	0	Myt1	31,35	Myelin_transcription_factor_1	0,29	Myt1	Myelin transcription factor 1	4661	4661	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Myelin_transcription_factor_1 -LRB- Myt1 -RRB- expression in demyelinated lesions of rodent and human CNS .
19204086	0	Myt1	41,45	c-Jun_N-terminal_kinase_1	0,25	Myt1	c-Jun N-terminal kinase 1	17932(Tax:10090)	26419(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Jun_N-terminal_kinase_1 phosphorylates Myt1 to prevent UVA-induced skin_cancer .
9001210	0	Myt1_kinase	10,21	Cdc2	52,56	Myt1 kinase	Cdc2	9088	983	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The human Myt1_kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex .
21193388	0	N-6_adenine-specific_DNA_methyltransferase_1	15,59	N6AMT1	61,67	N-6 adenine-specific DNA methyltransferase 1	N6AMT1	29104	29104	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of N-6_adenine-specific_DNA_methyltransferase_1 -LRB- N6AMT1 -RRB- in arsenic biomethylation and its role in arsenic-induced toxicity .
25380517	0	N-Acylethanolamine_Acid_Amidase	104,135	NAAA	137,141	N-Acylethanolamine Acid Amidase	NAAA	27163	27163	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Synthesis , Biological Evaluation , and 3D QSAR Study of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine_Acid_Amidase -LRB- NAAA -RRB- Inhibitors .
7526680	0	N-CAM	25,30	CD56	19,23	N-CAM	CD56	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High expression of CD56 -LRB- N-CAM -RRB- in a patient with cutaneous CD4-positive lymphoma .
7684798	0	N-CAM	0,5	CD56	7,11	N-CAM	CD56	4684	4684	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	N-CAM -LRB- CD56 -RRB- expression by CD34 + malignant myeloblasts has implications for minimal residual disease detection in acute_myeloid_leukemia .
7692192	0	N-CAM	23,28	CD56	30,34	N-CAM	CD56	4684	4684	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abnormal expression of N-CAM -LRB- CD56 -RRB- adhesion molecule on myeloid and progenitor cells from chronic myeloid_leukemia .
12229933	0	N-CAM	47,52	neural_cell_adhesion_molecule	16,45	N-CAM	neural cell adhesion molecule	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of neural_cell_adhesion_molecule -LRB- N-CAM -RRB- immunoreactivity in adult rat tissues .
1551227	0	N-CAM	64,69	neural_cell_adhesion_molecule	33,62	N-CAM	neural cell adhesion molecule	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of embryonic neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in the developing mouse cerebellum after neonatal administration of cytosine_arabinoside .
3025862	0	N-CAM	51,56	neural_cell_adhesion_molecule	20,49	N-CAM	neural cell adhesion molecule	428253(Tax:9031)	428253(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Organization of the neural_cell_adhesion_molecule -LRB- N-CAM -RRB- gene : alternative exon usage as the basis for different membrane-associated domains .
8581955	0	N-CAM	45,50	neural_cell_adhesion_molecule	14,43	N-CAM	neural cell adhesion molecule	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in perisinusoidal stellate cells of the human liver .
8701984	0	N-CAM	64,69	neural_cell_adhesion_molecule	33,62	N-CAM	neural cell adhesion molecule	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cell-type-specific expression of neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in Ito cells of rat liver .
9436925	0	N-CAM	67,72	neural_cell_adhesion_molecule	36,65	N-CAM	neural cell adhesion molecule	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential gene expression of the neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in a panel of multiple_myeloma cell lines .
20444543	0	N-Cadherin	14,24	CD34	42,46	N-Cadherin	CD34	1000	947	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Enrichment of N-Cadherin and Tie2-bearing CD34 + / CD38 - / CD123 + leukemic stem cells by chemotherapy-resistance .
24940649	0	N-Cadherin	39,49	Cadherin_11	0,11	N-Cadherin	Cadherin 11	1000	1009	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|appos|Expression	Cadherin_11 , a miR-675 Target , Induces N-Cadherin Expression and Epithelial-Mesenchymal Transition in Melasma .
25264609	0	N-Cadherin	55,65	SMAD4	0,5	N-Cadherin	SMAD4	1000	4089	Gene	Gene	Motility|nmod|START_ENTITY Motility|compound|END_ENTITY	SMAD4 Regulates Cell Motility through Transcription of N-Cadherin in Human Pancreatic Ductal Epithelium .
9566914	0	N-CoR	61,66	DAX-1	17,22	N-CoR	DAX-1	20185(Tax:10090)	11614(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1 .
10406466	0	N-CoR	33,38	MyoD	96,100	N-CoR	MyoD	9611	4654	Gene	Gene	regulates|nsubj|START_ENTITY regulates|parataxis|interacts interacts|nmod|END_ENTITY	The nuclear_receptor_corepressor N-CoR regulates differentiation : N-CoR directly interacts with MyoD .
10406466	0	N-CoR	66,71	MyoD	96,100	N-CoR	MyoD	9611	4654	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The nuclear_receptor_corepressor N-CoR regulates differentiation : N-CoR directly interacts with MyoD .
22887959	0	N-CoR	174,179	nuclear_receptor_co-repressor	143,172	N-CoR	nuclear receptor co-repressor	9611	9611	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Curcumin analogues with potent and selective anti-proliferative activity on acute_promyelocytic_leukemia : involvement of accumulated misfolded nuclear_receptor_co-repressor -LRB- N-CoR -RRB- protein as a basis for selective activity .
17327229	0	N-MYC	0,5	focal_adhesion_kinase	16,37	N-MYC	focal adhesion kinase	4613	5747	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	N-MYC regulates focal_adhesion_kinase expression in human neuroblastoma .
26185009	0	N-Methyl-D-Aspartate_Receptor	28,57	Mecp2	72,77	N-Methyl-D-Aspartate Receptor	Mecp2	14810(Tax:10090)	17257(Tax:10090)	Gene	Gene	Maturation|compound|START_ENTITY Maturation|nmod|END_ENTITY	Cell-Specific Regulation of N-Methyl-D-Aspartate_Receptor Maturation by Mecp2 in Cortical Circuits .
22202125	0	N-Myc	0,5	GSTP1	77,82	N-Myc	GSTP1	4613	2950	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1 , a marker of poor outcome in neuroblastoma .
17289033	0	N-Myc	22,27	p14ARF	0,6	N-Myc	p14ARF	4613	1029	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	p14ARF interacts with N-Myc and inhibits its transcriptional activity .
7601453	0	N-Oct_3	39,46	POUF3	53,58	N-Oct 3	POUF3	5454	5454	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation of the human genomic brain-2 / N-Oct_3 gene -LRB- POUF3 -RRB- and assignment to chromosome 6q16 .
15205937	0	N-RAP	63,68	muscle_LIM_protein	33,51	N-RAP	muscle LIM protein	4892	8048	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Decreased interactions of mutant muscle_LIM_protein -LRB- MLP -RRB- with N-RAP and alpha-actinin and their implication for hypertrophic_cardiomyopathy .
17130841	0	N-RAS	86,91	gelsolin	92,100	N-RAS	gelsolin	4893	2934	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS : gelsolin complex .
8590759	0	N-RAS	116,121	p53	20,23	N-RAS	p53	4893	7157	Gene	Gene	-RSB-|compound|START_ENTITY transformed|nmod|-RSB- transformed|nsubj|effect effect|nmod|END_ENTITY	-LSB- Opposite effect of p53 on nucleotide metabolizing enzyme activity in Rat1 cells and their sublines , transformed by N-RAS or v-mos oncogenes -RSB- .
18413234	0	N-Ras	52,57	Galectin-3	0,10	N-Ras	Galectin-3	4893	3958	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras .
25537506	0	N-Ras	21,26	SKP2	0,4	N-Ras	SKP2	18176(Tax:10090)	27401(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	SKP2 cooperates with N-Ras or AKT to induce liver_tumor development in mice .
14519669	0	N-Ras	72,77	VEGF-A_and_alphaVbeta3	0,22	N-Ras	VEGF-A and alphaVbeta3	4893	7422	Gene	Gene	angiogenesis|nmod|START_ENTITY angiogenesis|amod|END_ENTITY	VEGF-A_and_alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells .
16155590	0	N-WASP	31,37	Abi1	0,4	N-WASP	Abi1	8976	10006	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes .
11432863	0	N-WASP	226,232	Arp2/3	184,190	N-WASP	Arp2/3	8976	10097	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Identification of another actin-related protein -LRB- Arp -RRB- 2/3 complex binding site in neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- that complements actin polymerization induced by the Arp2/3 complex activating -LRB- VCA -RRB- domain of N-WASP .
23843614	0	N-WASP	50,56	Arp2/3	31,37	N-WASP	Arp2/3	8976	10097;10096	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The antagonistic modulation of Arp2/3 activity by N-WASP , WAVE2 and PICK1 defines dynamic changes in astrocyte morphology .
10995436	0	N-WASP	13,19	CDC42	34,39	N-WASP	CDC42	431898(Tax:8355)	379055(Tax:8355)	Gene	Gene	Mechanism|nmod|START_ENTITY activation|nsubj|Mechanism activation|nmod|END_ENTITY	Mechanism of N-WASP activation by CDC42 and phosphatidylinositol_4 , _ 5-bisphosphate .
22559840	0	N-WASP	65,71	Claudin-5	0,9	N-WASP	Claudin-5	8976	7122	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Claudin-5 is involved in breast_cancer cell motility through the N-WASP and ROCK signalling pathways .
15585574	0	N-WASP	57,63	Cortactin	0,9	N-WASP	Cortactin	8976	2017	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Cortactin regulates cell migration through activation of N-WASP .
14697212	0	N-WASP	40,46	FBP11	0,5	N-WASP	FBP11	8976	55660	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation .
20150425	0	N-WASP	20,26	Gas7	0,4	N-WASP	Gas7	682507(Tax:10116)	85246(Tax:10116)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons .
26305187	0	N-WASP	73,79	RTVP-1	0,6	N-WASP	RTVP-1	8976	11010	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK .
26305187	0	N-WASP	73,79	RTVP-1	0,6	N-WASP	RTVP-1	8976	11010	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK .
15625304	0	N-WASp	36,42	Arp2/3	18,24	N-WASp	Arp2/3	8976	10097;10096	Gene	Gene	complex|nmod|START_ENTITY complex|amod|END_ENTITY	Activation of the Arp2/3 complex by N-WASp is required for actin polymerization and contraction in smooth muscle .
6239831	0	N-acetyl-D-glucosamine	22,44	NAG	46,49	N-acetyl-D-glucosamine	NAG	4669	4669	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Synergistic effect of N-acetyl-D-glucosamine -LRB- NAG -RRB- on mitogenic , antigenic and allogeneic stimulation of normal human lymphocytes .
8001675	0	N-acetyl-L-cysteine	0,19	Syk	46,49	N-acetyl-L-cysteine	Syk	7504	6850	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	N-acetyl-L-cysteine inhibits antigen-mediated Syk , but not Lyn tyrosine kinase activation in mast cells .
11192539	0	N-acetyl-L-cysteine	0,19	interleukin-8	47,60	N-acetyl-L-cysteine	interleukin-8	7504	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	N-acetyl-L-cysteine inhibits bleomycin-induced interleukin-8 secretion by bronchial epithelial cells .
2891274	0	N-acetyl-beta-D-glucosaminidase	1,32	NAG	34,37	N-Acetyl-beta-D-glucosaminidase	NAG	10724	10724	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- activity in human semen : its relation to gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- activity in seminal plasma and reproductive tissues , and relation between seminal mucoprotein concentration and seminal NAG , and gamma-GTP activities -RSB- .
3534703	0	N-acetyl-beta-D-glucosaminidase	90,121	NAG	123,126	N-acetyl-beta-D-glucosaminidase	NAG	10724	10724	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- An early and specific indicator of aminoglycoside nephrotoxicity : isoenzyme B of urinary N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- -RSB- .
3618406	0	N-acetyl-beta-D-glucosaminidase	10,41	NAG	43,46	N-acetyl-beta-D-glucosaminidase	NAG	10724	10724	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Study of N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- activity in the human semen -RSB- .
3794453	0	N-acetyl-beta-D-glucosaminidase	26,57	NAG	59,62	N-acetyl-beta-D-glucosaminidase	NAG	10724	10724	Gene	Gene	excretion|amod|START_ENTITY excretion|appos|END_ENTITY	-LSB- Determination of urinary N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- excretion as a parameter of nephrotoxicity due to cis-platin and the effect of fosfomycin -LRB- FOM -RRB- on its nephrotoxicity -RSB- .
3803268	0	N-acetyl-beta-D-glucosaminidase	0,31	NAG	33,36	N-acetyl-beta-D-glucosaminidase	NAG	10724	10724	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- levels in amniotic fluid or urine in prenatal and postnatal life .
18308774	0	N-acetyl-beta-glucosaminidase	36,65	Beta-2-microglobulin	0,20	N-acetyl-beta-glucosaminidase	Beta-2-microglobulin	10724	567	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	Beta-2-microglobulin is superior to N-acetyl-beta-glucosaminidase in predicting prognosis in idiopathic_membranous_nephropathy .
10765593	0	N-acetyl-beta-glucosaminidase	1,30	NAG	32,35	N-acetyl-beta-glucosaminidase	NAG	10724	10724	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- N-acetyl-beta-glucosaminidase -LRB- NAG -RRB- activity in parturients with placental_insufficiency in postmature pregnancy and with EPH-gestosis -RSB- .
2668802	0	N-acetylated_alpha-linked_acidic_dipeptidase	15,59	NAALADase	61,70	N-acetylated alpha-linked acidic dipeptidase	NAALADase	219595	219595	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	The effects of N-acetylated_alpha-linked_acidic_dipeptidase -LRB- NAALADase -RRB- inhibitors on -LSB- 3H -RSB- NAAG catabolism in vivo .
23385884	0	N-acetylgalactosamine-4-sulfatase	27,60	arylsulfatase_B	62,77	N-acetylgalactosamine-4-sulfatase	arylsulfatase B	25227(Tax:10116)	25227(Tax:10116)	Gene	Gene	activity|nummod|START_ENTITY activity|compound|END_ENTITY	Impact of salt exposure on N-acetylgalactosamine-4-sulfatase -LRB- arylsulfatase_B -RRB- activity , glycosaminoglycans , kininogen , and bradykinin .
12442278	0	N-acetylgalactosamine-6-sulfate_sulfatase	119,160	GALNS	162,167	N-acetylgalactosamine-6-sulfate sulfatase	GALNS	2588	2588	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of Turkish mucopolysaccharidosis_IVA -LRB- Morquio A -RRB- patients : identification of novel mutations in the N-acetylgalactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene .
15241807	0	N-acetylgalactosamine-6-sulfate_sulfatase	87,128	GALNS	130,135	N-acetylgalactosamine-6-sulfate sulfatase	GALNS	2588	2588	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mucopolysaccharidosis_IVA -LRB- Morquio A -RRB- : identification of novel common mutations in the N-acetylgalactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene in Italian patients .
8325655	0	N-acetylgalactosamine-6-sulfate_sulfatase	52,93	GALNS	95,100	N-acetylgalactosamine-6-sulfate sulfatase	GALNS	2588	2588	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mucopolysaccharidosis IV A : assignment of the human N-acetylgalactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene to chromosome 16q24 .
8910459	0	N-acetylgalactosamine-6-sulfate_sulfatase	15,56	beta-galactosidase	99,117	N-acetylgalactosamine-6-sulfate sulfatase	beta-galactosidase	2588	2720	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of N-acetylgalactosamine-6-sulfate_sulfatase with the multienzyme lysosomal complex of beta-galactosidase , cathepsin_A , and neuraminidase .
25744272	0	N-acetylgalactosaminyltransferase_2	36,71	let-7b	8,14	N-acetylgalactosaminyltransferase 2	let-7b	79586	406884	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of let-7b in the regulation of N-acetylgalactosaminyltransferase_2 in IgA_nephropathy .
12174217	0	N-acetylglucosamine-phosphate_mutase	55,91	phosphoglucomutase_3	24,44	N-acetylglucosamine-phosphate mutase	phosphoglucomutase 3	5238	5238	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human phosphoglucomutase_3 -LRB- PGM3 -RRB- as N-acetylglucosamine-phosphate_mutase -LRB- AGM1 -RRB- .
16404719	0	N-acetylglucosaminyl_transferase_V	37,71	protein_tyrosine_phosphatase_kappa	114,148	N-acetylglucosaminyl transferase V	protein tyrosine phosphatase kappa	4249	5796	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of target proteins of N-acetylglucosaminyl_transferase_V in human colon_cancer and implications of protein_tyrosine_phosphatase_kappa in enhanced cancer cell migration .
16434023	0	N-acetylglucosaminyltransferase-IVa_and_IVb	23,66	GnT-IVa_and_b	68,81	N-acetylglucosaminyltransferase-IVa and IVb	GnT-IVa and b	11320;11282	11320	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Aberrant expression of N-acetylglucosaminyltransferase-IVa_and_IVb -LRB- GnT-IVa_and_b -RRB- in pancreatic_cancer .
12716887	0	N-acetylglucosaminyltransferase_III	52,87	Caveolin-1	0,10	N-acetylglucosaminyltransferase III	Caveolin-1	4248	857	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase_III within the golgi apparatus .
16940045	0	N-acetylglucosaminyltransferase_III	0,35	N-acetylglucosaminyltransferase_V	62,95	N-acetylglucosaminyltransferase III	N-acetylglucosaminyltransferase V	4248	4249	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|effect effect|nmod|END_ENTITY	N-acetylglucosaminyltransferase_III antagonizes the effect of N-acetylglucosaminyltransferase_V on alpha3beta1 integrin-mediated cell migration .
21771782	0	N-acetylglucosaminyltransferase_IX	29,63	GnT-IX	65,71	N-acetylglucosaminyltransferase IX	GnT-IX	146664	146664	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Brain-specific expression of N-acetylglucosaminyltransferase_IX -LRB- GnT-IX -RRB- is regulated by epigenetic histone modifications .
25524127	0	N-acetylglucosaminyltransferase_V	26,59	GnT-V	61,66	N-acetylglucosaminyltransferase V	GnT-V	107895(Tax:10090)	107895(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Predominant expression of N-acetylglucosaminyltransferase_V -LRB- GnT-V -RRB- in neural stem/progenitor cells .
12122020	0	N-acetylglucosaminyltransferase_V	23,56	Mgat5	58,63	N-acetylglucosaminyltransferase V	Mgat5	107895(Tax:10090)	107895(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Sequences of the mouse N-acetylglucosaminyltransferase_V -LRB- Mgat5 -RRB- mRNA and an mRNA expressed by an Mgat5-deficient cell line .
16940045	0	N-acetylglucosaminyltransferase_V	62,95	N-acetylglucosaminyltransferase_III	0,35	N-acetylglucosaminyltransferase V	N-acetylglucosaminyltransferase III	4249	4248	Gene	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	N-acetylglucosaminyltransferase_III antagonizes the effect of N-acetylglucosaminyltransferase_V on alpha3beta1 integrin-mediated cell migration .
17421020	0	N-acetylglutamate_synthase	41,67	NAGS	69,73	N-acetylglutamate synthase	NAGS	162417	162417	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations and polymorphisms in the human N-acetylglutamate_synthase -LRB- NAGS -RRB- gene .
23250120	0	N-acetylglutamate_synthase	32,58	NAGS	26,30	N-acetylglutamate synthase	NAGS	162417	162417	Gene	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Recurrent encephalopathy : NAGS -LRB- N-acetylglutamate_synthase -RRB- deficiency in adults .
11393533	0	N-acetyltransferase	66,85	NAT1	92,96	N-acetyltransferase	NAT1	10	9	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Identification of single-nucleotide polymorphisms -LRB- SNPs -RRB- of human N-acetyltransferase genes NAT1 , NAT2 , AANAT , ARD1 and L1CAM in the Japanese population .
8442668	0	N-acetyltransferase	38,57	NAT1	65,69	N-acetyltransferase	NAT1	6046	9	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus .
10970160	0	N-acetyltransferase	67,86	NAT2	88,92	N-acetyltransferase	NAT2	10	10	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel allele containing a 190C > T nonsynonymous substitution in the N-acetyltransferase -LRB- NAT2 -RRB- gene .
12877350	0	N-acetyltransferase	10,29	NAT2	44,48	N-acetyltransferase	NAT2	10	10	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Impact of N-acetyltransferase polymorphism -LRB- NAT2 -RRB- in hepatocellular_carcinoma -LRB- HCC -RRB- -- an investigation in a department of surgical medicine .
9170149	0	N-acetyltransferase	28,47	NAT2	49,53	N-acetyltransferase	NAT2	17961(Tax:10090)	17961(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of polymorphic N-acetyltransferase -LRB- NAT2 -RRB- in tissues of inbred mice .
17675654	0	N-acetyltransferase_1_and_2	21,48	NAT1	50,54	N-acetyltransferase 1 and 2	NAT1	10	9	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Joint effects of the N-acetyltransferase_1_and_2 -LRB- NAT1 and NAT2 -RRB- genes and smoking on bladder carcinogenesis : a literature-based systematic HuGE review and evidence synthesis .
18544910	0	N-acetyltransferase_2	11,32	GST	79,82	N-acetyltransferase 2	GST	10	373156	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of N-acetyltransferase_2 -LRB- NAT2 -RRB- , CYP2E1 and Glutathione-S-transferase -LRB- GST -RRB- genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients .
11337936	0	N-acetyltransferase_2	37,58	NAT2	60,64	N-acetyltransferase 2	NAT2	10	10	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of human N-acetyltransferase_2 -LRB- NAT2 -RRB- single nucleotide polymorphisms .
18544910	0	N-acetyltransferase_2	11,32	NAT2	34,38	N-acetyltransferase 2	NAT2	10	10	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of N-acetyltransferase_2 -LRB- NAT2 -RRB- , CYP2E1 and Glutathione-S-transferase -LRB- GST -RRB- genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients .
26700672	0	N-acetyltransferase_2	71,92	NAT2	94,98	N-acetyltransferase 2	NAT2	10	10	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Active cigarette smoking and the risk of breast_cancer at the level of N-acetyltransferase_2 -LRB- NAT2 -RRB- gene polymorphisms .
20550432	0	N-acetyltransferase_2	0,21	Nat2	23,27	N-acetyltransferase 2	Nat2	116632(Tax:10116)	116632(Tax:10116)	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	N-acetyltransferase_2 -LRB- Nat2 -RRB- polymorphism in the sand rat Psammomys obesus .
18280460	0	N-acetyltransferase_type_1	57,83	N-acetyltransferase_type_2	6,32	N-acetyltransferase type 1	N-acetyltransferase type 2	9	10	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Mouse N-acetyltransferase_type_2 , the homologue of human N-acetyltransferase_type_1 .
18280460	0	N-acetyltransferase_type_2	6,32	N-acetyltransferase_type_1	57,83	N-acetyltransferase type 2	N-acetyltransferase type 1	10	9	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Mouse N-acetyltransferase_type_2 , the homologue of human N-acetyltransferase_type_1 .
11432822	0	N-arginine_dibasic_convertase	0,29	heparin-binding_EGF-like_growth_factor	57,95	N-arginine dibasic convertase	heparin-binding EGF-like growth factor	4898	1839	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	N-arginine_dibasic_convertase is a specific receptor for heparin-binding_EGF-like_growth_factor that mediates cell migration .
17414625	0	N-cadherin	9,19	ADH1	0,4	N-cadherin	ADH1	1000	124	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	ADH1 , an N-cadherin inhibitor , evaluated in preclinical models of angiogenesis and androgen-independent prostate_cancer .
23618343	0	N-cadherin	18,28	AKT	0,3	N-cadherin	AKT	1000	207	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	AKT activation by N-cadherin regulates beta-catenin signaling and neuronal differentiation during cortical development .
25864110	0	N-cadherin	42,52	C-reactive_protein	0,18	N-cadherin	C-reactive protein	12558(Tax:10090)	12944(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	C-reactive_protein inhibits expression of N-cadherin and ZEB-1 in murine colon_adenocarcinoma .
15383621	0	N-cadherin	26,36	Cortactin	0,9	N-cadherin	Cortactin	83501(Tax:10116)	60465(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts .
10545506	0	N-cadherin	0,10	E-cadherin	78,88	N-cadherin	E-cadherin	1000	999	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advmod|regardless regardless|nmod|expression expression|amod|END_ENTITY	N-cadherin promotes motility in human breast_cancer cells regardless of their E-cadherin expression .
15252840	0	N-cadherin	17,27	E-cadherin	31,41	N-cadherin	E-cadherin	1000	999	Gene	Gene	Neoexpression|nmod|START_ENTITY Neoexpression|nmod|colon_cancers colon_cancers|amod|END_ENTITY	Neoexpression of N-cadherin in E-cadherin positive colon_cancers .
16132038	0	N-cadherin	64,74	E-cadherin	39,49	N-cadherin	E-cadherin	1000	999	Gene	Gene	expression|amod|START_ENTITY Influence|nmod|expression Influence|nmod|domain domain|nmod|END_ENTITY	Influence of the cytoplasmic domain of E-cadherin on endogenous N-cadherin expression in malignant_melanoma .
18056176	0	N-cadherin	28,38	E-cadherin	14,24	N-cadherin	E-cadherin	1000	999	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate_cancer .
20534673	0	N-cadherin	0,10	E-cadherin	43,53	N-cadherin	E-cadherin	12558(Tax:10090)	12550(Tax:10090)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation .
21822911	0	N-cadherin	123,133	E-cadherin	111,121	N-cadherin	E-cadherin	1000	999	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of TWIST decreases migration and invasion of laryngeal_carcinoma Hep-2 cells by regulating the E-cadherin , N-cadherin expression .
22696497	0	N-cadherin	32,42	E-cadherin	0,10	N-cadherin	E-cadherin	12558(Tax:10090)	12550(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nsubj|and and|compound|END_ENTITY	E-cadherin and , in its absence , N-cadherin promotes Nanog expression in mouse embryonic stem cells via STAT3 phosphorylation .
24091815	0	N-cadherin	0,10	E-cadherin	76,86	N-cadherin	E-cadherin	1000	999	Gene	Gene	Expression|compound|START_ENTITY Associated|nsubj|Expression Associated|nmod|Expression Expression|compound|END_ENTITY	N-cadherin Expression in Feline Mammary_Tumors Is Associated With a Reduced E-cadherin Expression and the Presence of Regional Metastasis .
25014356	0	N-cadherin	23,33	E-cadherin	0,10	N-cadherin	E-cadherin	12558(Tax:10090)	12550(Tax:10090)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	E-cadherin can replace N-cadherin during secretory-stage enamel development .
25438959	0	N-cadherin	8,18	E-cadherin	46,56	N-cadherin	E-cadherin	1000	999	Gene	Gene	Loss|nmod|START_ENTITY associated|nsubjpass|Loss associated|nmod|loss loss|nmod|expression expression|amod|END_ENTITY	Loss of N-cadherin is associated with loss of E-cadherin expression and poor outcomes of liver resection in hepatocellular_carcinoma .
26792846	0	N-cadherin	12,22	E-cadherin	0,10	N-cadherin	E-cadherin	1000	999	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	E-cadherin , N-cadherin Expression and Histologic Characterization of Canine Choroid_Plexus_Tumors .
25143387	0	N-cadherin	49,59	Fbxo45	0,6	N-cadherin	Fbxo45	1000	200933	Gene	Gene	Proteolysis|nmod|START_ENTITY Proteolysis|compound|END_ENTITY	Fbxo45 Inhibits Calcium-sensitive Proteolysis of N-cadherin and Promotes Neuronal Differentiation .
11180398	0	N-cadherin	45,55	Fibroblast_growth_factor-2	0,26	N-cadherin	Fibroblast growth factor-2	1000	2247	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts .
18495274	0	N-cadherin	18,28	HGF	58,61	N-cadherin	HGF	12558(Tax:10090)	15234(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role of N-cadherin in hepatocyte_growth_factor -LRB- HGF -RRB- mediated improvement of the cardiac function of dilated_cardiomyopathy_mice .
16279949	0	N-cadherin	54,64	HMGN1	20,25	N-cadherin	HMGN1	12558(Tax:10090)	15312(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Chromosomal protein HMGN1 modulates the expression of N-cadherin .
19448425	0	N-cadherin	14,24	N-cadherin	91,101	N-cadherin	N-cadherin	1000	1000	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Expression of N-cadherin in esophageal_squamous_cell_carcinoma and silencing expression of N-cadherin using RNA interference on invasiveness of EC9706 cells .
19448425	0	N-cadherin	91,101	N-cadherin	14,24	N-cadherin	N-cadherin	1000	1000	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Expression of N-cadherin in esophageal_squamous_cell_carcinoma and silencing expression of N-cadherin using RNA interference on invasiveness of EC9706 cells .
22696497	0	N-cadherin	32,42	Nanog	52,57	N-cadherin	Nanog	12558(Tax:10090)	71950(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	E-cadherin and , in its absence , N-cadherin promotes Nanog expression in mouse embryonic stem cells via STAT3 phosphorylation .
17054946	0	N-cadherin	32,42	Optimedin	0,9	N-cadherin	Optimedin	83501(Tax:10116)	252920(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells .
25088803	0	N-cadherin	0,10	PTH	21,24	N-cadherin	PTH	12558(Tax:10090)	19226(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	N-cadherin Restrains PTH Activation of Lrp6/b-catenin Signaling and Osteoanabolic Action .
25313909	0	N-cadherin	93,103	TWIST	79,84	N-cadherin	TWIST	1000	7291	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Gonadotropin_Releasing_Hormone Regulates Human Trophoblastic Cell Invasion via TWIST Induced N-cadherin Expression .
19075000	0	N-cadherin	0,10	axin	26,30	N-cadherin	axin	12558(Tax:10090)	12005(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling , osteoblast function , and bone formation .
15723280	0	N-cadherin	0,10	beta-catenin	36,48	N-cadherin	beta-catenin	12558(Tax:10090)	12387(Tax:10090)	Gene	Gene	distribution|amod|START_ENTITY distribution|nmod|END_ENTITY	N-cadherin mediated distribution of beta-catenin alters MAP kinase and BMP-2 signaling on chondrogenesis-related gene expression .
16707106	0	N-cadherin	70,80	beta-catenin	33,45	N-cadherin	beta-catenin	1000	1499	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin .
19401766	0	N-cadherin	32,42	beta-catenin	51,63	N-cadherin	beta-catenin	1000	1499	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate .
23481397	0	N-cadherin	0,10	p120ctn	66,73	N-cadherin	p120ctn	1000	1500	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	N-cadherin regulates spatially polarized signals through distinct p120ctn and b-catenin-dependent signalling pathways .
15204682	0	N-ethyl_maleimide_sensitive_factor	12,46	NSF	48,51	N-ethyl maleimide sensitive factor	NSF	4905	4905	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of N-ethyl_maleimide_sensitive_factor -LRB- NSF -RRB- on the acrosome of mammalian sperm .
12130635	0	N-ethylmaleimide-sensitive_factor	151,184	GluR2	185,190	N-ethylmaleimide-sensitive factor	GluR2	4905	2891	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Brain-derived_neurotrophic_factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic_acid receptors by enhancing the N-ethylmaleimide-sensitive_factor / GluR2 interaction in developing neocortical neurons .
7961908	0	N-ethylmaleimide-sensitive_fusion_protein	23,64	ATPase	4,10	N-ethylmaleimide-sensitive fusion protein	ATPase	4905	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The ATPase activity of N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is regulated by soluble NSF attachment proteins .
10438719	0	N-ethylmaleimide-sensitive_fusion_protein	20,61	NSF	63,66	N-ethylmaleimide-sensitive fusion protein	NSF	4905	4905	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A critical role for N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- in platelet granule secretion .
12162901	0	N-methyl-D-asparate_receptor_1	34,64	nerve_growth_factor	11,30	N-methyl-D-asparate receptor 1	nerve growth factor	24408(Tax:10116)	310738(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nerve_growth_factor on N-methyl-D-asparate_receptor_1 after spinal_cord_injury in rats .
15385364	0	N-methyl-D-aspartate_receptor	70,99	GluRepsilon1	100,112	N-methyl-D-aspartate receptor	GluRepsilon1	14810(Tax:10090)	14811(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Reduced sensitivity to ketamine and pentobarbital in mice lacking the N-methyl-D-aspartate_receptor GluRepsilon1 subunit .
22536327	0	N-methyl-D-aspartate_receptor	84,113	NMDAR	115,120	N-methyl-D-aspartate receptor	NMDAR	14810(Tax:10090)	14810(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Prion_protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate_receptor -LRB- NMDAR -RRB- activity .
10762705	0	N-methyl-D-aspartate_receptor	26,55	NMDAR1	57,63	N-methyl-D-aspartate receptor	NMDAR1	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Hippocampal expression of N-methyl-D-aspartate_receptor -LRB- NMDAR1 -RRB- subunit splice variant mRNA is altered by developmental exposure to Pb -LRB- 2 + -RRB- .
10188938	0	N-methyl-D-aspartate_receptor	0,29	sorcin	116,122	N-methyl-D-aspartate receptor	sorcin	24408(Tax:10116)	683667(Tax:10116)	Gene	Gene	START_ENTITY|dep|localization localization|nmod|END_ENTITY	N-methyl-D-aspartate_receptor 1 in the caudate-putamen nucleus : ultrastructural localization and co-expression with sorcin , a 22,000 mol .
8399301	0	N-methyl-D-aspartate_receptor_1	60,91	NMDAR1	93,99	N-methyl-D-aspartate receptor 1	NMDAR1	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and analysis of the 5 ' flanking sequence of the rat N-methyl-D-aspartate_receptor_1 -LRB- NMDAR1 -RRB- gene .
12363394	0	N-methyl-D-aspartate_receptor_subunit_NR1	58,99	GRIN1	106,111	N-methyl-D-aspartate receptor subunit NR1	GRIN1	2902	2902	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate_receptor_subunit_NR1 gene -LRB- GRIN1 -RRB- : implications for schizophrenia .
15338240	0	N-methyl-D-aspartate_receptors	24,54	NMDAR1	56,62	N-methyl-D-aspartate receptors	NMDAR1	2902	2902	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of epidermal N-methyl-D-aspartate_receptors -LRB- NMDAR1 -RRB- depends on formation of the granular layer -- analysis in diseases with parakeratotic cornification .
12014652	0	N-methylpurine-DNA_glycosylase	46,76	MPG	78,81	N-methylpurine-DNA glycosylase	MPG	4350	4350	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression of the DNA_repair_protein , N-methylpurine-DNA_glycosylase -LRB- MPG -RRB- in human gonads .
9328183	0	N-methylpurine-DNA_glycosylase	68,98	MPG	100,103	N-methylpurine-DNA glycosylase	MPG	4350	4350	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the promoter of the human N-methylpurine-DNA_glycosylase -LRB- MPG -RRB- gene .
9684856	0	N-methylpurine-DNA_glycosylase	46,76	MPG	78,81	N-methylpurine-DNA glycosylase	MPG	4350	4350	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression of the DNA_repair_protein , N-methylpurine-DNA_glycosylase -LRB- MPG -RRB- in breast_cancer .
15660126	0	N-myc	67,72	EAAT2	36,41	N-myc	EAAT2	4613	6506	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Positive and negative regulation of EAAT2 by NF-kappaB : a role for N-myc in TNFalpha-controlled repression .
1730410	0	N-myc	22,27	Interleukin-7	0,13	N-myc	Interleukin-7	4613	3574	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes .
26160903	0	N-myc	20,25	Otx2	0,4	N-myc	Otx2	4613	5015	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea .
18278068	0	N-myc	0,5	VEGF	44,48	N-myc	VEGF	4613	7422	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma .
1374683	0	N-myc	14,19	c-myc	21,26	N-myc	c-myc	4613	4609	Gene	Gene	START_ENTITY|appos|proteins proteins|amod|END_ENTITY	Expression of N-myc , c-myc , and MDR-1 proteins in newly established neuroblastoma cell lines : a study by immunofluorescence staining and flow cytometry .
12153570	0	N-myc	0,5	leukemia_inhibitory_factor	45,71	N-myc	leukemia inhibitory factor	4613	3976	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	N-myc oncogene overexpression down-regulates leukemia_inhibitory_factor in neuroblastoma .
2183016	0	N-myc	0,5	neural_cell_adhesion_molecule	21,50	N-myc	neural cell adhesion molecule	298894(Tax:10116)	24586(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	N-myc down regulates neural_cell_adhesion_molecule expression in rat neuroblastoma .
21541626	0	N-myc	183,188	neuropeptide_Y	19,33	N-myc	neuropeptide Y	4613	4852	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|receptor receptor|amod|END_ENTITY	Gene expression of neuropeptide_Y and neuropeptide-Y1 receptor in relation to proto-oncogene tyrosine_kinase_A , nerve-growth-factor low-affinity-receptor and the transcription factor N-myc in human neuroblastomas .
12192602	0	N-myc	0,5	p73	30,33	N-myc	p73	4613	7161	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	N-myc modulates expression of p73 in neuroblastoma .
22974759	0	N-myc_and_STAT_interactor	19,44	Nmi	46,49	N-myc and STAT interactor	Nmi	9111;4613	9111	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A critical role of N-myc_and_STAT_interactor -LRB- Nmi -RRB- in foot-and-mouth_disease virus -LRB- FMDV -RRB- 2C-induced apoptosis .
26646663	0	N-myc_downstream-regulated_gene	18,49	NDRG2	53,58	N-myc downstream-regulated gene	NDRG2	57447	57447	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Low expression of N-myc_downstream-regulated_gene 2 -LRB- NDRG2 -RRB- correlates with poor prognosis in hepatoblastoma .
26506239	0	N-myc_downstream-regulated_gene_2	17,50	NDRG2	52,57	N-myc downstream-regulated gene 2	NDRG2	57447	57447	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Emerging role of N-myc_downstream-regulated_gene_2 -LRB- NDRG2 -RRB- in cancer .
19800102	0	N-myc_downstream_regulated_gene-1	0,33	Cap43	34,39	N-myc downstream regulated gene-1	Cap43	10397	10397	Gene	Gene	START_ENTITY|parataxis|play play|nsubj|END_ENTITY	N-myc_downstream_regulated_gene-1 / Cap43 may play an important role in malignant_progression_of_prostate_cancer , in its close association with E-cadherin .
20582309	0	N-myc_downstream_regulated_gene_1	18,51	NDRG1	53,58	N-myc downstream regulated gene 1	NDRG1	482049(Tax:9615)	482049(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A deletion in the N-myc_downstream_regulated_gene_1 -LRB- NDRG1 -RRB- gene in Greyhounds with polyneuropathy .
21784644	0	N-myc_downstream_regulated_gene_1	14,47	NDRG1	49,54	N-myc downstream regulated gene 1	NDRG1	10397	10397	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of N-myc_downstream_regulated_gene_1 -LRB- NDRG1 -RRB- in central_neurocytoma .
14572661	0	N-myc_downstream_regulated_gene_2	36,69	NDRG2	29,34	N-myc downstream regulated gene 2	NDRG2	57447	57447	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of NDRG2 -LRB- N-myc_downstream_regulated_gene_2 -RRB- during the differentiation of dendritic cells .
15644961	0	N-myristoyl_transferase	46,69	NMT	71,74	N-myristoyl transferase	NMT	543128(Tax:4565)	543128(Tax:4565)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization of a gene encoding N-myristoyl_transferase -LRB- NMT -RRB- from Triticum_aestivum -LRB- bread_wheat -RRB- .
21449607	0	N-myristoyltransferase_1	30,54	Nef	17,20	N-myristoyltransferase 1	Nef	4836	156110(Tax:11676)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of HIV-1 Nef on human N-myristoyltransferase_1 .
26603938	0	N-myristoyltransferase_1	0,24	calnexin	40,48	N-myristoyltransferase 1	calnexin	4836	821	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	N-myristoyltransferase_1 interacts with calnexin at the endoplasmic reticulum .
10504052	0	N-ras	8,13	Bcl-2	26,31	N-ras	Bcl-2	4893	596	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Mutated N-ras upregulates Bcl-2 in human melanoma in vitro and in SCID mice .
11172613	0	N-ras	23,28	p16INK4a	35,43	N-ras	p16INK4a	4893	1029	Gene	Gene	p14ARF|compound|START_ENTITY p14ARF|dep|END_ENTITY	Mutational analysis of N-ras , p53 , p16INK4a , p14ARF and CDK4 genes in primary human malignant mesotheliomas .
1844332	0	N-ras	112,117	p21	47,50	N-ras	p21	4893	644914	Gene	Gene	expression|compound|START_ENTITY lines|nmod|expression localization|nmod|lines localization|nmod|protein protein|amod|END_ENTITY	Immunoelectron microscopic localization of the p21 protein in HT1080 human fibrosarcoma cell lines with altered N-ras gene expression .
1844338	0	N-ras	112,117	p21	47,50	N-ras	p21	4893	644914	Gene	Gene	expression|compound|START_ENTITY lines|nmod|expression localization|nmod|lines localization|nmod|protein protein|amod|END_ENTITY	Immunoelectron microscopic localization of the p21 protein in HT1080 human fibrosarcoma cell lines with altered N-ras gene expression .
3550423	0	N-ras	51,56	p21	57,60	N-ras	p21	4893	644914	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Biochemical and biological properties of the human N-ras p21 protein .
6667677	0	N-ras	26,31	p21	62,65	N-ras	p21	4893	644914	Gene	Gene	oncogene|compound|START_ENTITY Localisation|nmod|oncogene Localisation|dep|END_ENTITY	Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation .
8208513	0	N-ras	110,115	p21	43,46	N-ras	p21	4893	644914	Gene	Gene	gene|compound|START_ENTITY possessing|dobj|gene cells|acl|possessing Inhibition|nmod|cells Inhibition|nmod|proteins proteins|amod|END_ENTITY	Inhibition of the membrane localization of p21 ras proteins by lovastatin in tumor cells possessing a mutated N-ras gene .
10192423	0	N-ras	68,73	p53	103,106	N-ras	p53	4893	7157	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Molecular evolution of acute_myeloid_leukaemia in relapse : unstable N-ras and FLT3 genes compared with p53 gene .
11172613	0	N-ras	23,28	p53	30,33	N-ras	p53	4893	7157	Gene	Gene	p14ARF|compound|START_ENTITY p14ARF|dep|END_ENTITY	Mutational analysis of N-ras , p53 , p16INK4a , p14ARF and CDK4 genes in primary human malignant mesotheliomas .
8217795	0	N-ras	123,128	p53	33,36	N-ras	p53	4893	7157	Gene	Gene	mutation|compound|START_ENTITY carrying|dobj|mutation increased|xcomp|carrying increased|nsubjpass|Occurrence Occurrence|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Occurrence of point mutations in p53 gene is not increased in patients with acute_myeloid_leukaemia carrying an activating N-ras mutation .
21900231	0	N-terminal_acetyltransferase	41,69	Naa50p	23,29	N-terminal acetyltransferase	Naa50p	80155	80218	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	Structure of a ternary Naa50p -LRB- NAT5/SAN -RRB- N-terminal_acetyltransferase complex reveals the molecular basis for substrate-specific acetylation .
18830408	0	N1L	77,80	CD8	22,25	N1L	CD8	3707643(Tax:10245)	925	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia_virus .
21193388	0	N6AMT1	61,67	N-6_adenine-specific_DNA_methyltransferase_1	15,59	N6AMT1	N-6 adenine-specific DNA methyltransferase 1	29104	29104	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of N-6_adenine-specific_DNA_methyltransferase_1 -LRB- N6AMT1 -RRB- in arsenic biomethylation and its role in arsenic-induced toxicity .
11865415	0	NA	41,43	neuraminidase	26,39	NA	neuraminidase	4758	4758	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Accumulation of defective neuraminidase -LRB- NA -RRB- genes by influenza A viruses in the presence of NA inhibitors as a marker of reduced dependence on NA .
22808012	0	NA	75,77	neuraminidase	60,73	NA	neuraminidase	4758	4758	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Evolutionary history and phylodynamics of influenza A and B neuraminidase -LRB- NA -RRB- genes inferred from large-scale sequence analyses .
23100800	0	NA	27,29	neuraminidase	12,25	NA	neuraminidase	4758	4758	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Efficacy of neuraminidase -LRB- NA -RRB- inhibitors against H1N1 strains of different geographical regions : an in silico approach .
15269182	0	NA14	47,51	Spastin	0,7	NA14	Spastin	8636	6683	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Spastin interacts with the centrosomal protein NA14 , and is enriched in the spindle pole , the midbody and the distal axon .
22048246	0	NAA11	20,25	ARD1B	27,32	NAA11	ARD1B	84779	84779	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of human NAA11 -LRB- ARD1B -RRB- gene is tissue-specific and is regulated by DNA methylation .
25380517	0	NAAA	137,141	N-Acylethanolamine_Acid_Amidase	104,135	NAAA	N-Acylethanolamine Acid Amidase	27163	27163	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Synthesis , Biological Evaluation , and 3D QSAR Study of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters as N-Acylethanolamine_Acid_Amidase -LRB- NAAA -RRB- Inhibitors .
2668802	0	NAALADase	61,70	N-acetylated_alpha-linked_acidic_dipeptidase	15,59	NAALADase	N-acetylated alpha-linked acidic dipeptidase	219595	219595	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	The effects of N-acetylated_alpha-linked_acidic_dipeptidase -LRB- NAALADase -RRB- inhibitors on -LSB- 3H -RSB- NAAG catabolism in vivo .
12427750	0	NAB2	0,4	EGR-1	23,28	NAB2	EGR-1	17937(Tax:10090)	13653(Tax:10090)	Gene	Gene	START_ENTITY|appos|corepressor corepressor|nmod|END_ENTITY	NAB2 , a corepressor of EGR-1 , inhibits vascular_endothelial_growth_factor-mediated gene induction and angiogenic responses of endothelial cells .
17174939	0	NAB2	44,48	Egr-1	76,81	NAB2	Egr-1	4665	1958	Gene	Gene	isoforms|nmod|START_ENTITY isoforms|acl:relcl|corepressors corepressors|nmod|END_ENTITY	FGF23 induces expression of two isoforms of NAB2 , which are corepressors of Egr-1 .
18203138	0	NAB2	48,52	Egr-1	42,47	NAB2	Egr-1	17937(Tax:10090)	13653(Tax:10090)	Gene	Gene	Egr-3|dep|START_ENTITY Egr-3|amod|END_ENTITY	Opposing regulation of T cell function by Egr-1 / NAB2 and Egr-2 / Egr-3 .
8668170	0	NAB2	0,4	Egr-1	31,36	NAB2	Egr-1	4665	1958	Gene	Gene	START_ENTITY|appos|corepressor corepressor|nmod|END_ENTITY	NAB2 , a corepressor of NGFI-A -LRB- Egr-1 -RRB- and Krox20 , is induced by proliferative and differentiative stimuli .
15934011	0	NAC	21,24	cyclooxygenase-2	89,105	NAC	cyclooxygenase-2	7504	5743	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells .
23869562	0	NAC103	45,51	bZIP60	66,72	NAC103	bZIP60	836527(Tax:3702)	840897(Tax:3702)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The plant-specific transcription factor gene NAC103 is induced by bZIP60 through a new cis-regulatory element to modulate the unfolded protein response in Arabidopsis .
7568089	0	NACP	0,4	A_beta	118,124	NACP	A beta	6622	351	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer_disease amyloid , binds A_beta and stimulates A_beta aggregation .
7568089	0	NACP	0,4	A_beta	64,70	NACP	A beta	6622	351	Gene	Gene	START_ENTITY|appos|protein protein|nmod|component component|appos|END_ENTITY	NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer_disease amyloid , binds A_beta and stimulates A_beta aggregation .
9462843	0	NACP	24,28	A_beta	179,185	NACP	A beta	6622	351	Gene	Gene	Self-oligomerization|nmod|START_ENTITY observed|nsubj|Self-oligomerization observed|nmod|presence presence|nmod|fragment fragment|compound|END_ENTITY	Self-oligomerization of NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer 's _ disease amyloid , observed in the presence of a C-terminal A_beta fragment -LRB- residues 25-35 -RRB- .
9462843	0	NACP	24,28	A_beta	88,94	NACP	A beta	6622	351	Gene	Gene	Self-oligomerization|nmod|START_ENTITY Self-oligomerization|appos|protein protein|nmod|component component|appos|END_ENTITY	Self-oligomerization of NACP , the precursor protein of the non-amyloid beta/A4 protein -LRB- A_beta -RRB- component of Alzheimer 's _ disease amyloid , observed in the presence of a C-terminal A_beta fragment -LRB- residues 25-35 -RRB- .
22133261	0	NAC_transcription_factor	8,32	SND2	0,4	NAC transcription factor	SND2	828144(Tax:3702)	828968(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	SND2 , a NAC_transcription_factor gene , regulates genes involved in secondary cell wall development in Arabidopsis fibres and increases fibre cell area in Eucalyptus .
10764727	0	NADE	0,4	p75NTR	127,133	NADE	p75NTR	27018	4804	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|transduction transduction|acl|mediated mediated|nmod|END_ENTITY	NADE , a p75NTR-associated_cell_death_executor , is involved in signal transduction mediated by the common neurotrophin receptor p75NTR .
11224788	0	NADE	48,52	p75NTR	14,20	NADE	p75NTR	117089(Tax:10116)	24596(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p75NTR and its associated protein NADE in the rat cochlea .
10354494	0	NADH-quinone_oxidoreductase	121,148	NDI1	150,154	NADH-quinone oxidoreductase	NDI1	854919(Tax:4932)	854919(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Modulation of oxidative phosphorylation of human kidney 293 cells by transfection with the internal rotenone-insensitive NADH-quinone_oxidoreductase -LRB- NDI1 -RRB- gene of Saccharomyces_cerevisiae .
10982813	0	NADH-quinone_oxidoreductase	11,38	NDI1	40,44	NADH-quinone oxidoreductase	NDI1	854919(Tax:4932)	854919(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Use of the NADH-quinone_oxidoreductase -LRB- NDI1 -RRB- gene of Saccharomyces_cerevisiae as a possible cure for complex I defects in human cells .
11479321	0	NADH-quinone_oxidoreductase	136,163	NDI1	165,169	NADH-quinone oxidoreductase	NDI1	854919(Tax:4932)	854919(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces_cerevisiae NADH-quinone_oxidoreductase -LRB- NDI1 -RRB- gene .
25904941	0	NADH_Dehydrogenase_I	110,130	ND1	132,135	NADH Dehydrogenase I	ND1	4535	4535	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Molecular Differentiation of Fasciola Species and Characterization of Genetic Diversity of F. gigantica Using NADH_Dehydrogenase_I -LRB- ND1 -RRB- Gene in the Endemic Areas of Iran .
17019704	0	NADPH	100,105	DHFR	80,84	NADPH	DHFR	67460(Tax:10090)	13361(Tax:10090)	Gene	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	New insights into DHFR interactions : analysis of Pneumocystis_carinii and mouse DHFR complexes with NADPH and two highly potent 5 - -LRB- omega-carboxy -LRB- alkyloxy -RRB- trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions .
21206056	0	NADPH	74,79	DHFR	54,58	NADPH	DHFR	1666	1719	Gene	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Structural analysis of Pneumocystis_carinii and human DHFR complexes with NADPH and a series of five potent 6 - -LSB- 5 ' - -LRB- __ - carboxyalkoxy -RRB- benzyl -RSB- pyrido -LSB- 2,3-d -RSB- pyrimidine derivatives .
10318800	0	NADPH	40,45	catalase	28,36	NADPH	catalase	1666	847	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|nmod|END_ENTITY	Mechanisms of protection of catalase by NADPH .
9109647	0	NADPH	59,64	dihydrofolate_reductase	99,122	NADPH	dihydrofolate reductase	1666	1719	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate_reductase .
24380729	0	NADPH-oxidase_2	56,71	p21-Activated_kinase1	0,21	NADPH-oxidase 2	p21-Activated kinase1	13058(Tax:10090)	18479(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	p21-Activated_kinase1 -LRB- Pak1 -RRB- is a negative regulator of NADPH-oxidase_2 in ventricular myocytes .
18997460	0	NADPH-quinone_oxidoreductase	42,70	NQO1	72,76	NADPH-quinone oxidoreductase	NQO1	24314(Tax:10116)	24314(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The natural compound ascorbigen modulates NADPH-quinone_oxidoreductase -LRB- NQO1 -RRB- mRNA and enzyme activity levels in cultured liver cells and in laboratory_rats .
23119229	0	NADPH_oxidase	61,74	NOX2	75,79	NADPH oxidase	NOX2	1536	1536	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Phosphorylation of p47phox is required for receptor-mediated NADPH_oxidase / NOX2 activation in Epstein-Barr_virus-transformed human B lymphocytes .
17869312	0	NADPH_oxidase	89,102	Nox2	104,108	NADPH oxidase	Nox2	1536	1536	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Implication of cytosolic_phospholipase_A2 -LRB- cPLA2 -RRB- in the regulation of human synoviocyte NADPH_oxidase -LRB- Nox2 -RRB- activity .
21042717	0	NADPH_oxidase	14,27	Nox2	29,33	NADPH oxidase	Nox2	1536	1536	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of NADPH_oxidase -LRB- Nox2 -RRB- by lipid rafts in breast_carcinoma cells .
23695780	0	NADPH_oxidase	33,46	Nox2	48,52	NADPH oxidase	Nox2	1536	1536	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Activation of apocynin-sensitive NADPH_oxidase -LRB- Nox2 -RRB- activity in INS-1 832/13 cells under glucotoxic conditions .
19433064	0	NADPH_oxidase	70,83	STIM1	0,5	NADPH oxidase	STIM1	1536	6786	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	STIM1 but not STIM2 is an essential regulator of Ca2 + influx-mediated NADPH_oxidase activity in neutrophil-like HL-60 cells .
25128166	0	NADPH_oxidase	52,65	glucagon-like_peptide-1	19,42	NADPH oxidase	glucagon-like peptide-1	66021(Tax:10116)	24952(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	AMPK activation by glucagon-like_peptide-1 prevents NADPH_oxidase activation induced by hyperglycemia in adult cardiomyocytes .
22340895	0	NADPH_oxidase	130,143	gp91phox	110,118	NADPH oxidase	gp91phox	1536	1536	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH_oxidase .
23119229	0	NADPH_oxidase	61,74	p47phox	19,26	NADPH oxidase	p47phox	1536	653361	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of p47phox is required for receptor-mediated NADPH_oxidase / NOX2 activation in Epstein-Barr_virus-transformed human B lymphocytes .
23087362	0	NADPH_oxidase_1	79,94	CD47	42,46	NADPH oxidase 1	CD47	27035	961	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH_oxidase_1 .
22549734	0	NADPH_oxidase_1	75,90	NOX1	92,96	NADPH oxidase 1	NOX1	237038(Tax:10090)	237038(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	The p47phox - _ and_NADPH_oxidase_organiser_1 -LRB- NOXO1 -RRB- - dependent activation of NADPH_oxidase_1 -LRB- NOX1 -RRB- mediates endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- uncoupling and endothelial_dysfunction in a streptozotocin-induced murine model of diabetes .
26753853	0	NADPH_oxidase_1	8,23	NOX1	25,29	NADPH oxidase 1	NOX1	27035	27035	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of NADPH_oxidase_1 -LRB- NOX1 -RRB- in gut inflammation .
21326871	0	NADPH_oxidase_1	19,34	PPARa	71,76	NADPH oxidase 1	PPARa	237038(Tax:10090)	19013(Tax:10090)	Gene	Gene	blocks|nsubj|START_ENTITY blocks|nmod|mechanism mechanism|compound|END_ENTITY	Targeting vascular NADPH_oxidase_1 blocks tumor angiogenesis through a PPARa mediated mechanism .
16329988	0	NADPH_oxidase_1	25,40	betaPix	46,53	NADPH oxidase 1	betaPix	27035	8874	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Molecular interaction of NADPH_oxidase_1 with betaPix and Nox_Organizer_1 .
18454179	0	NADPH_oxidase_1	0,15	vascular_endothelial_growth_factor	73,107	NADPH oxidase 1	vascular endothelial growth factor	114243(Tax:10116)	83785(Tax:10116)	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|expression expression|compound|END_ENTITY	NADPH_oxidase_1 plays a critical mediating role in oncogenic Ras-induced vascular_endothelial_growth_factor expression .
22493499	0	NADPH_oxidase_2	98,113	NOX2	115,119	NADPH oxidase 2	NOX2	13058(Tax:10090)	13058(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Receptor signaling_lymphocyte-activation_molecule_family_1 -LRB- Slamf1 -RRB- regulates membrane fusion and NADPH_oxidase_2 -LRB- NOX2 -RRB- activity by recruiting a Beclin-1 / Vps34/ultraviolet _ radiation_resistance-associated_gene -LRB- UVRAG -RRB- complex .
21683690	0	NADPH_oxidase_2	61,76	SUMO1	0,5	NADPH oxidase 2	SUMO1	1536	7341	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH_oxidase_2 .
19265148	0	NADPH_oxidase_2	0,15	TLR2	33,37	NADPH oxidase 2	TLR2	1536	7097	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	NADPH_oxidase_2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression .
25982880	0	NADPH_oxidase_2	47,62	cardiac_myosin_light_chain_2	8,36	NADPH oxidase 2	cardiac myosin light chain 2	66021(Tax:10116)	363925(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Nuclear cardiac_myosin_light_chain_2 modulates NADPH_oxidase_2 expression in myocardium : a novel function beyond muscle contraction .
25982880	0	NADPH_oxidase_2	47,62	cardiac_myosin_light_chain_2	8,36	NADPH oxidase 2	cardiac myosin light chain 2	66021(Tax:10116)	363925(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Nuclear cardiac_myosin_light_chain_2 modulates NADPH_oxidase_2 expression in myocardium : a novel function beyond muscle contraction .
24629065	0	NADPH_oxidase_4	39,54	Transforming_growth_factor-b1	0,29	NADPH oxidase 4	Transforming growth factor-b1	50490(Tax:10090)	21803(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Transforming_growth_factor-b1 requires NADPH_oxidase_4 for angiogenesis in vitro and in vivo .
21788590	0	NADPH_oxidase_4	0,15	endothelial_nitric_oxide_synthase	58,91	NADPH oxidase 4	endothelial nitric oxide synthase	50490(Tax:10090)	18127(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|amod|END_ENTITY	NADPH_oxidase_4 promotes endothelial angiogenesis through endothelial_nitric_oxide_synthase activation .
20396861	0	NADPH_oxidase_4	24,39	p38	43,46	NADPH oxidase 4	p38	50507	1432	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Sustained expression of NADPH_oxidase_4 by p38 MAPK-Akt signaling potentiates radiation-induced differentiation of lung fibroblasts .
21074607	0	NADPH_oxidase_4	0,15	smooth_muscle_a-actin	39,60	NADPH oxidase 4	smooth muscle a-actin	50507	6606	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	NADPH_oxidase_4 mediates TGF-b-induced smooth_muscle_a-actin via p38MAPK and serum_response_factor .
22387196	0	NADPH_oxidase_5	21,36	Nox5	38,42	NADPH oxidase 5	Nox5	79400	79400	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Nitric_oxide reduces NADPH_oxidase_5 -LRB- Nox5 -RRB- activity by reversible S-nitrosylation .
18929641	0	NADPH_oxidase_organizer_1	59,84	NOXO1	86,91	NADPH oxidase organizer 1	NOXO1	124056	124056	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tumor_necrosis_factor_alpha activates transcription of the NADPH_oxidase_organizer_1 -LRB- NOXO1 -RRB- gene and upregulates superoxide production in colon epithelial cells .
17712600	0	NAF1	65,69	CBF5	12,16	NAF1	CBF5	855599(Tax:4932)	850872(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arabidopsis CBF5 interacts with the H/ACA snoRNP assembly factor NAF1 .
6239831	0	NAG	46,49	N-acetyl-D-glucosamine	22,44	NAG	N-acetyl-D-glucosamine	4669	4669	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of N-acetyl-D-glucosamine -LRB- NAG -RRB- on mitogenic , antigenic and allogeneic stimulation of normal human lymphocytes .
2891274	0	NAG	34,37	N-acetyl-beta-D-glucosaminidase	1,32	NAG	N-Acetyl-beta-D-glucosaminidase	10724	10724	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- activity in human semen : its relation to gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- activity in seminal plasma and reproductive tissues , and relation between seminal mucoprotein concentration and seminal NAG , and gamma-GTP activities -RSB- .
3534703	0	NAG	123,126	N-acetyl-beta-D-glucosaminidase	90,121	NAG	N-acetyl-beta-D-glucosaminidase	10724	10724	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- An early and specific indicator of aminoglycoside nephrotoxicity : isoenzyme B of urinary N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- -RSB- .
3618406	0	NAG	43,46	N-acetyl-beta-D-glucosaminidase	10,41	NAG	N-acetyl-beta-D-glucosaminidase	10724	10724	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Study of N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- activity in the human semen -RSB- .
3794453	0	NAG	59,62	N-acetyl-beta-D-glucosaminidase	26,57	NAG	N-acetyl-beta-D-glucosaminidase	10724	10724	Gene	Gene	excretion|appos|START_ENTITY excretion|amod|END_ENTITY	-LSB- Determination of urinary N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- excretion as a parameter of nephrotoxicity due to cis-platin and the effect of fosfomycin -LRB- FOM -RRB- on its nephrotoxicity -RSB- .
3803268	0	NAG	33,36	N-acetyl-beta-D-glucosaminidase	0,31	NAG	N-acetyl-beta-D-glucosaminidase	10724	10724	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- levels in amniotic fluid or urine in prenatal and postnatal life .
10765593	0	NAG	32,35	N-acetyl-beta-glucosaminidase	1,30	NAG	N-acetyl-beta-glucosaminidase	10724	10724	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- N-acetyl-beta-glucosaminidase -LRB- NAG -RRB- activity in parturients with placental_insufficiency in postmature pregnancy and with EPH-gestosis -RSB- .
744553	0	NAG	26,29	Neuraminidase	0,13	NAG	Neuraminidase	51594	4758	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Neuraminidase activity of NAG vibrios and of some representatives of the intestinal group of bacteria .
3976723	0	NAG	70,73	alpha-N-acetyl-D-glucosaminidase	36,68	NAG	alpha-N-acetyl-D-glucosaminidase	4669	4669	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Segregation and linkage analysis of alpha-N-acetyl-D-glucosaminidase -LRB- NAG -RRB- levels in a black family .
15080564	0	NAG	53,56	beta-N-acetylhexosaminidase	24,51	NAG	beta-N-acetylhexosaminidase	10724	10724	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Age dependence of serum beta-N-acetylhexosaminidase -LRB- NAG -RRB- activity .
21205743	0	NAG-1	12,17	GDF15	18,23	NAG-1	GDF15	23886(Tax:10090)	23886(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of NAG-1 / GDF15 in the inhibition of intestinal_polyps in APC/Min mice by sulindac .
23261467	0	NAG-1	35,40	GDF15	41,46	NAG-1	GDF15	9518	9518	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Proteasome inhibitor MG132 induces NAG-1 / GDF15 expression through the p38 MAPK pathway in glioblastoma cells .
21504622	0	NAG-1	14,19	JNK	24,27	NAG-1	JNK	9518	5599	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP_prostate_cancer cells .
23261467	0	NAG-1	35,40	MG132	21,26	NAG-1	MG132	9518	875581(Tax:243273)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Proteasome inhibitor MG132 induces NAG-1 / GDF15 expression through the p38 MAPK pathway in glioblastoma cells .
17237295	0	NAG-1	42,47	glycogen_synthase_kinase-3beta	52,82	NAG-1	glycogen synthase kinase-3beta	9518	2932	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Prodigiosin induces the proapoptotic gene NAG-1 via glycogen_synthase_kinase-3beta activity in human breast_cancer cells .
18264720	0	NAG-1	68,73	nonsteroidal_anti-inflammatory_drug-activated_gene-1	14,66	NAG-1	nonsteroidal anti-inflammatory drug-activated gene-1	9518	9518	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of nonsteroidal_anti-inflammatory_drug-activated_gene-1 -LRB- NAG-1 -RRB- inversely correlates with tumor progression in gastric_adenomas and carcinomas .
18413810	0	NAG-1	28,33	p38	50,53	NAG-1	p38	9518	1432	Gene	Gene	expression|compound|START_ENTITY expression|nmod|mechanism mechanism|amod|END_ENTITY	Vitamin_E_succinate induces NAG-1 expression in a p38 kinase-dependent mechanism .
12918109	0	NAG-7	40,45	BRD7	47,51	NAG-7	BRD7	29931	29117	Gene	Gene	Expression|amod|START_ENTITY Expression|appos|END_ENTITY	Expression of tumor related genes NGX6 , NAG-7 , BRD7 in gastric and colorectal_cancer .
17421020	0	NAGS	69,73	N-acetylglutamate_synthase	41,67	NAGS	N-acetylglutamate synthase	162417	162417	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations and polymorphisms in the human N-acetylglutamate_synthase -LRB- NAGS -RRB- gene .
23250120	0	NAGS	26,30	N-acetylglutamate_synthase	32,58	NAGS	N-acetylglutamate synthase	162417	162417	Gene	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Recurrent encephalopathy : NAGS -LRB- N-acetylglutamate_synthase -RRB- deficiency in adults .
11930148	0	NAIP	62,66	neuronal_apoptosis_inhibitory_protein	23,60	NAIP	neuronal apoptosis inhibitory protein	17940(Tax:10090)	17940(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Distinct expression of neuronal_apoptosis_inhibitory_protein -LRB- NAIP -RRB- during murine development .
7589118	0	NAK-1	15,20	nur77	32,37	NAK-1	nur77	3164	3164	Gene	Gene	START_ENTITY|appos|homologue homologue|amod|END_ENTITY	Involvement of NAK-1 , the human nur77 homologue , in surface IgM-mediated apoptosis in Burkitt_lymphoma cell line BL41 .
17142768	0	NAK-associated_protein_1	0,24	TLR3	50,54	NAK-associated protein 1	TLR3	64343	7098	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	NAK-associated_protein_1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction .
17418785	0	NALP1	83,88	Bcl-2	0,5	NALP1	Bcl-2	22861	596	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1 .
15285719	0	NALP1	0,5	cAMP-response-element-binding_protein	38,75	NALP1	cAMP-response-element-binding protein	22861	1385	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	NALP1 is a transcriptional target for cAMP-response-element-binding_protein -LRB- CREB -RRB- in myeloid_leukaemia cells .
17178985	0	NALP3	124,129	CIAS-1	117,123	NALP3	CIAS-1	114548	114548	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Phenotype , genotype , and sustained response to anakinra in 22 patients with autoinflammatory_disease associated with CIAS-1 / NALP3 mutations .
25017793	0	NALP3	41,46	Thioredoxin-interacting_protein	0,31	NALP3	Thioredoxin-interacting protein	114548	10628	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Thioredoxin-interacting_protein mediates NALP3 inflammasome activation in podocytes during diabetic_nephropathy .
26330272	0	NALT	7,11	NOTCH1	29,35	NALT	NOTCH1	101928483	4851	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute_lymphoblastic_leukemia .
8200349	0	NAM1	4,8	NAM1p	18,23	NAM1	NAM1p	851517(Tax:4932)	851517(Tax:4932)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The NAM1 protein -LRB- NAM1p -RRB- , which is selectively required for cox1 , cytb and atp6 transcript processing/stabilisation , is located in the yeast mitochondrial matrix .
8200349	0	NAM1p	18,23	NAM1	4,8	NAM1p	NAM1	851517(Tax:4932)	851517(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The NAM1 protein -LRB- NAM1p -RRB- , which is selectively required for cox1 , cytb and atp6 transcript processing/stabilisation , is located in the yeast mitochondrial matrix .
26389889	0	NAMPT	55,60	Nicotinamide_Phosphoribosyltransferase	15,53	NAMPT	Nicotinamide Phosphoribosyltransferase	10135	10135	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of Nicotinamide_Phosphoribosyltransferase -LRB- NAMPT -RRB- Gene Polymorphisms and of Serum NAMPT Levels with Dilated_Cardiomyopathy in a Chinese Population .
26389889	0	NAMPT	55,60	Nicotinamide_Phosphoribosyltransferase	15,53	NAMPT	Nicotinamide Phosphoribosyltransferase	10135	10135	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of Nicotinamide_Phosphoribosyltransferase -LRB- NAMPT -RRB- Gene Polymorphisms and of Serum NAMPT Levels with Dilated_Cardiomyopathy in a Chinese Population .
24347567	0	NAMPT	0,5	hypoxia-inducible_factor-2a	37,64	NAMPT	hypoxia-inducible factor-2a	59027(Tax:10090)	13819(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	NAMPT -LRB- visfatin -RRB- , a direct target of hypoxia-inducible_factor-2a , is an essential catabolic regulator of osteoarthritis .
23153509	0	NAMPT	19,24	miR-182	39,46	NAMPT	miR-182	10135	406958	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat -LRB- LTR -RRB- transactivation .
24053186	0	NAMPT	61,66	miR-374a	107,115	NAMPT	miR-374a	10135	442919	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Mechanical stress induces pre-B-cell_colony-enhancing_factor / NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium .
24389478	0	NAMPT	62,67	nicotinamide_phosphoribosyl_transferase	21,60	NAMPT	nicotinamide phosphoribosyl transferase	10135	10135	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of a novel nicotinamide_phosphoribosyl_transferase -LRB- NAMPT -RRB- inhibitor via in silico screening .
22570471	0	NAMPT	54,59	nicotinamide_phosphoribosyltransferase	14,52	NAMPT	nicotinamide phosphoribosyltransferase	10135	10135	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of nicotinamide_phosphoribosyltransferase -LRB- NAMPT -RRB- activity by small molecule GMX1778 regulates reactive oxygen species -LRB- ROS -RRB- - mediated cytotoxicity in a p53 - and nicotinic_acid phosphoribosyltransferase1 -LRB- NAPRT1 -RRB- - dependent manner .
25709099	0	NAMPT	54,59	nicotinamide_phosphoribosyltransferase	14,52	NAMPT	nicotinamide phosphoribosyltransferase	10135	10135	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of nicotinamide_phosphoribosyltransferase -LRB- NAMPT -RRB- as a therapeutic strategy in cancer .
24053186	0	NAMPT	61,66	pre-B-cell_colony-enhancing_factor	26,60	NAMPT	pre-B-cell colony-enhancing factor	10135	10135	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Mechanical stress induces pre-B-cell_colony-enhancing_factor / NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium .
23953183	0	NAMPT	68,73	visfatin	58,66	NAMPT	visfatin	10135	10135	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of genetic variability in selected regions in visfatin -LRB- NAMPT -RRB- gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population .
25918435	0	NAMPT	25,30	visfatin	32,40	NAMPT	visfatin	10135	10135	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and effect of NAMPT -LRB- visfatin -RRB- on progesterone secretion in hen granulosa cells .
25918435	0	NAMPT	25,30	visfatin	32,40	NAMPT	visfatin	10135	10135	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and effect of NAMPT -LRB- visfatin -RRB- on progesterone secretion in hen granulosa cells .
25724006	0	NANOG	157,162	BRG1	31,35	NANOG	BRG1	79923	6597	Gene	Gene	silencing|nmod|START_ENTITY associated|nmod|silencing senescence|acl|associated induces|dobj|senescence induces|nsubj|expression expression|nmod|factor factor|compound|END_ENTITY	De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins .
25271810	0	NANOG	17,22	HIF-2a	0,6	NANOG	HIF-2a	79923	2034	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	HIF-2a regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element .
20410807	0	NANOG	59,64	OCT4	53,57	NANOG	OCT4	79923	5460	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	NANOG	59,64	SALL4	46,51	NANOG	SALL4	79923	57167	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	NANOG	59,64	SOX2	66,70	NANOG	SOX2	79923	6657	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
26582088	0	NANOG	19,24	STAT3	41,46	NANOG	STAT3	71950(Tax:10090)	20848(Tax:10090)	Gene	Gene	Cooperates|compound|START_ENTITY Cooperates|nmod|END_ENTITY	TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice .
20410807	0	NANOG	59,64	UTF1	72,76	NANOG	UTF1	79923	8433	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
23661244	0	NANOG	119,124	c-JUN	100,105	NANOG	c-JUN	79923	3725	Gene	Gene	determining|advcl|START_ENTITY determining|dobj|association association|nmod|protein protein|amod|END_ENTITY	The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter .
25213759	0	NANOG	0,5	c-jun	18,23	NANOG	c-jun	79923	3725	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	NANOG upregulates c-jun oncogene expression through binding the c-jun promoter .
25213759	0	NANOG	0,5	c-jun	64,69	NANOG	c-jun	79923	3725	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|promoter promoter|amod|END_ENTITY	NANOG upregulates c-jun oncogene expression through binding the c-jun promoter .
22963770	0	NANOG	75,80	growth_and_differentiation_factor_3	20,55	NANOG	growth and differentiation factor 3	79923	9573	Gene	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	Regulation of human growth_and_differentiation_factor_3 gene expression by NANOG in human embryonic_carcinoma NCCIT cells .
25120646	0	NANOG	106,111	hypoxia-inducible_factor-1a	132,159	NANOG	hypoxia-inducible factor-1a	79923	3091	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Immunohistochemical expression of four different stem cell markers in prostate_cancer : High expression of NANOG in conjunction with hypoxia-inducible_factor-1a expression is involved in prostate epithelial malignancy .
23683786	0	NANOG	39,44	p53	179,182	NANOG	p53	79923	7157	Gene	Gene	silencing|nmod|START_ENTITY leads|nsubj|silencing leads|nmod|cells cells|nmod|END_ENTITY	RNA interference-mediated silencing of NANOG leads to reduced proliferation and self-renewal , cell cycle arrest and apoptosis in T-cell_acute_lymphoblastic_leukemia cells via the p53 signaling pathway .
22102605	0	NANOS2	0,6	glial_cell_line-derived_neurotrophic_factor	26,69	NANOS2	glial cell line-derived neurotrophic factor	378430(Tax:10090)	14573(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	NANOS2 acts downstream of glial_cell_line-derived_neurotrophic_factor signaling to suppress differentiation of spermatogonial stem cells .
1711550	0	NAP-1	69,74	IL-8	75,79	NAP-1	IL-8	3576	3576	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Upper keratinocytes of psoriatic skin_lesions express high levels of NAP-1 / IL-8 mRNA in situ .
2405845	0	NAP-1	0,5	IL-8	6,10	NAP-1	IL-8	3576	3576	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|END_ENTITY	NAP-1 / IL-8 induces up-regulation of CR1 receptors in human neutrophil leukocytes .
8334226	0	NAP-1	53,58	IL-8	48,52	NAP-1	IL-8	3576	3576	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Cell type specific expression of members of the IL-8 / NAP-1 gene family .
1997632	0	NAP-1	175,180	NAP-2	160,165	NAP-1	NAP-2	3576	5473	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Chemotactic activity and receptor binding of neutrophil_attractant / activation_protein-1 -LRB- NAP-1 -RRB- and structurally related host defense cytokines : interaction of NAP-2 with the NAP-1 receptor .
1997632	0	NAP-1	89,94	NAP-2	160,165	NAP-1	NAP-2	3576	5473	Gene	Gene	activation_protein-1|appos|START_ENTITY activity|nmod|activation_protein-1 activity|dep|interaction interaction|nmod|END_ENTITY	Chemotactic activity and receptor binding of neutrophil_attractant / activation_protein-1 -LRB- NAP-1 -RRB- and structurally related host defense cytokines : interaction of NAP-2 with the NAP-1 receptor .
1740648	0	NAP-1	129,134	fMLP	110,114	NAP-1	fMLP	3576	2357	Gene	Gene	START_ENTITY|nmod|mobilization mobilization|nmod|END_ENTITY	Heterogeneity in the mobilization of cytoplasmic calcium by human polymorphonuclear leukocytes in response to fMLP , C5a and IL-8 / NAP-1 .
2189453	0	NAP-1	44,49	interleukin-8	51,64	NAP-1	interleukin-8	3576	3576	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Neutrophil attractant/activation protein-1 -LRB- NAP-1 -LSB- interleukin-8 -RSB- -RRB- .
1997632	0	NAP-2	160,165	NAP-1	175,180	NAP-2	NAP-1	5473	3576	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Chemotactic activity and receptor binding of neutrophil_attractant / activation_protein-1 -LRB- NAP-1 -RRB- and structurally related host defense cytokines : interaction of NAP-2 with the NAP-1 receptor .
1997632	0	NAP-2	160,165	NAP-1	89,94	NAP-2	NAP-1	5473	3576	Gene	Gene	interaction|nmod|START_ENTITY activity|dep|interaction activity|nmod|activation_protein-1 activation_protein-1|appos|END_ENTITY	Chemotactic activity and receptor binding of neutrophil_attractant / activation_protein-1 -LRB- NAP-1 -RRB- and structurally related host defense cytokines : interaction of NAP-2 with the NAP-1 receptor .
21932368	0	NAP-22	21,27	synaptojanin-1	59,73	NAP-22	synaptojanin-1	10409	8867	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	Inhibitory effect of NAP-22 on the phosphatase activity of synaptojanin-1 .
7622567	0	NAP1	0,4	Clb1	15,19	NAP1	Clb1	853922(Tax:4932)	853002(Tax:4932)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	NAP1 acts with Clb1 to perform mitotic functions and to suppress polar bud growth in budding yeast .
22539786	0	NAP1	140,144	Tripartite_motif-containing_protein_38	0,38	NAP1	Tripartite motif-containing protein 38	64343	10475	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	Tripartite_motif-containing_protein_38 negatively regulates TLR3/4 - _ and_RIG-I-mediated_IFN-b production and antiviral response by targeting NAP1 .
17965550	0	NAP1	54,58	nucleosome_assembly_protein_1	23,52	NAP1	nucleosome assembly protein 1	561894(Tax:7955)	561894(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Abundant expression of nucleosome_assembly_protein_1 -LRB- NAP1 -RRB- gene in goldfish scale with lateral line .
9325046	0	NAP1L4	68,74	nucleosome_assembly_protein-2	37,66	NAP1L4	nucleosome assembly protein-2	4676	4676	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of human nucleosome_assembly_protein-2 -LRB- NAP1L4 -RRB- suggests a role as a histone chaperone .
26675378	0	NAPRT	62,67	nicotinate_phosphoribosyltransferase	24,60	NAPRT	nicotinate phosphoribosyltransferase	93100	93100	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Extensive regulation of nicotinate_phosphoribosyltransferase -LRB- NAPRT -RRB- expression in human tissues and tumors .
22209457	0	NAR	104,107	nicotinic_acid_receptor	79,102	NAR	nicotinic acid receptor	353250(Tax:10116)	353250(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	SAR studies of C2_ethers of 2H-pyrano -LSB- 2,3-d -RSB- pyrimidine-2 ,4,7 -LRB- 1H ,3 H -RRB- - triones as nicotinic_acid_receptor -LRB- NAR -RRB- agonist .
16906563	0	NAT1	48,52	GSTT1	60,65	NAT1	GSTT1	9	2952	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Risk of limb deficiency_defects associated with NAT1 , NAT2 , GSTT1 , GSTM1 , and NOS3 genetic variants , maternal smoking , and vitamin supplement intake .
11393533	0	NAT1	92,96	N-acetyltransferase	66,85	NAT1	N-acetyltransferase	9	10	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Identification of single-nucleotide polymorphisms -LRB- SNPs -RRB- of human N-acetyltransferase genes NAT1 , NAT2 , AANAT , ARD1 and L1CAM in the Japanese population .
8442668	0	NAT1	65,69	N-acetyltransferase	38,57	NAT1	N-acetyltransferase	9	6046	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus .
17675654	0	NAT1	50,54	N-acetyltransferase_1_and_2	21,48	NAT1	N-acetyltransferase 1 and 2	9	10	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Joint effects of the N-acetyltransferase_1_and_2 -LRB- NAT1 and NAT2 -RRB- genes and smoking on bladder carcinogenesis : a literature-based systematic HuGE review and evidence synthesis .
16906563	0	NAT1	48,52	NAT2	54,58	NAT1	NAT2	9	10	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Risk of limb deficiency_defects associated with NAT1 , NAT2 , GSTT1 , GSTM1 , and NOS3 genetic variants , maternal smoking , and vitamin supplement intake .
7627961	0	NAT1	62,66	acetyltransferase_1	36,55	NAT1	acetyltransferase 1	9	51471	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polyadenylation polymorphism in the acetyltransferase_1 gene -LRB- NAT1 -RRB- increases risk of colorectal_cancer .
8895478	0	NAT1	68,72	acetyltransferase_1	74,93	NAT1	acetyltransferase 1	9	51471	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association between the polyadenylation polymorphism in the NAT1 -LRB- acetyltransferase_1 -RRB- gene and colorectal_adenomas .
1762071	0	NAT1	57,61	monomorphic_arylamine_N-acetyltransferase	14,55	NAT1	monomorphic arylamine N-acetyltransferase	9	9	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of monomorphic_arylamine_N-acetyltransferase -LRB- NAT1 -RRB- in human leukocytes .
26882543	0	NAT10	0,5	p53	16,19	NAT10	p53	55226	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2 .
12879168	0	NAT2	76,80	CYP1A1	68,74	NAT2	CYP1A1	10	1543	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	NAT2	96,100	CYP1A1	30,36	NAT2	CYP1A1	10	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
14582254	0	NAT2	9,13	CYP1A2	1,7	NAT2	CYP1A2	10	1544	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CYP1A2 , NAT2 , and GSTM1 phenotype/genotype modulate human exposure and various environmental mutagens : our experience -RSB- .
12879168	0	NAT2	76,80	CYP2C19	51,58	NAT2	CYP2C19	10	1557	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	NAT2	96,100	CYP2C19	46,53	NAT2	CYP2C19	10	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20941486	0	NAT2	0,4	CYP2C19	14,21	NAT2	CYP2C19	10	1557	Gene	Gene	CYP2C9|nummod|START_ENTITY CYP2C9|nummod|END_ENTITY	NAT2 , CYP2C9 , CYP2C19 , and CYP2E1 genetic polymorphisms in anti-TB drug-induced maculopapular_eruption .
12879168	0	NAT2	76,80	CYP2C9	43,49	NAT2	CYP2C9	10	1559	Gene	Gene	and|appos|START_ENTITY and|compound|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	NAT2	96,100	CYP2C9	38,44	NAT2	CYP2C9	10	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12879168	0	NAT2	76,80	CYP2D6	60,66	NAT2	CYP2D6	10	1565	Gene	Gene	and|appos|START_ENTITY and|appos|END_ENTITY	Polymorphisms of drug-metabolizing enzymes CYP2C9 , CYP2C19 , CYP2D6 , CYP1A1 , NAT2 and of P-glycoprotein in a Russian population .
20373852	0	NAT2	96,100	CYP2D6	55,61	NAT2	CYP2D6	10	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
16112301	0	NAT2	0,4	GSTM1	23,28	NAT2	GSTM1	10	2944	Gene	Gene	acetylation|nummod|START_ENTITY acetylation|appos|genotype genotype|nummod|END_ENTITY	NAT2 slow acetylation , GSTM1 null genotype , and risk of bladder_cancer : results from the Spanish Bladder_Cancer Study and meta-analyses .
18986377	0	NAT2	69,73	GSTM1	49,54	NAT2	GSTM1	10	2944	Gene	Gene	PSTI|appos|START_ENTITY PSTI|compound|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
19303722	0	NAT2	15,19	GSTM1	21,26	NAT2	GSTM1	10	2944	Gene	Gene	CYP2A6|compound|START_ENTITY CYP2A6|appos|END_ENTITY	Association of NAT2 , GSTM1 , GSTT1 , CYP2A6 , and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder_cancer in Central China .
20373852	0	NAT2	96,100	GSTM1	70,75	NAT2	GSTM1	10	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
22788240	0	NAT2	28,32	GSTM1	34,39	NAT2	GSTM1	10	2944	Gene	Gene	CYP2E1|compound|START_ENTITY CYP2E1|appos|END_ENTITY	Genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors is associated with adverse reactions to anti-tuberculosis drugs .
9891107	0	NAT2	23,27	GSTM1	63,68	NAT2	GSTM1	10	2944	Gene	Gene	N-Acetyltransferase_2|appos|START_ENTITY END_ENTITY|nsubj|N-Acetyltransferase_2	N-Acetyltransferase_2 -LRB- NAT2 -RRB- and Glutathione_S-Transferase -LRB- GSTM1 -RRB- in Bladder-cancer Patients in a Highly Industrialized Area .
16906563	0	NAT2	54,58	GSTT1	60,65	NAT2	GSTT1	10	2952	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Risk of limb deficiency_defects associated with NAT1 , NAT2 , GSTT1 , GSTM1 , and NOS3 genetic variants , maternal smoking , and vitamin supplement intake .
18986377	0	NAT2	69,73	GSTT1	56,61	NAT2	GSTT1	10	2952	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
19303722	0	NAT2	15,19	GSTT1	28,33	NAT2	GSTT1	10	2952	Gene	Gene	CYP2A6|compound|START_ENTITY CYP2A6|appos|END_ENTITY	Association of NAT2 , GSTM1 , GSTT1 , CYP2A6 , and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder_cancer in Central China .
20373852	0	NAT2	96,100	GSTT1	63,68	NAT2	GSTT1	10	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
22788240	0	NAT2	28,32	GSTT1	41,46	NAT2	GSTT1	10	2952	Gene	Gene	CYP2E1|compound|START_ENTITY CYP2E1|appos|END_ENTITY	Genetic interaction between NAT2 , GSTM1 , GSTT1 , CYP2E1 , and environmental factors is associated with adverse reactions to anti-tuberculosis drugs .
18986377	0	NAT2	69,73	LPL	75,78	NAT2	LPL	10	4023	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20373852	0	NAT2	96,100	MTHFR	77,82	NAT2	MTHFR	10	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	NAT2	96,100	MTRR	84,88	NAT2	MTRR	10	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
10970160	0	NAT2	88,92	N-acetyltransferase	67,86	NAT2	N-acetyltransferase	10	10	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel allele containing a 190C > T nonsynonymous substitution in the N-acetyltransferase -LRB- NAT2 -RRB- gene .
12877350	0	NAT2	44,48	N-acetyltransferase	10,29	NAT2	N-acetyltransferase	10	10	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Impact of N-acetyltransferase polymorphism -LRB- NAT2 -RRB- in hepatocellular_carcinoma -LRB- HCC -RRB- -- an investigation in a department of surgical medicine .
9170149	0	NAT2	49,53	N-acetyltransferase	28,47	NAT2	N-acetyltransferase	17961(Tax:10090)	17961(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of polymorphic N-acetyltransferase -LRB- NAT2 -RRB- in tissues of inbred mice .
11337936	0	NAT2	60,64	N-acetyltransferase_2	37,58	NAT2	N-acetyltransferase 2	10	10	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of human N-acetyltransferase_2 -LRB- NAT2 -RRB- single nucleotide polymorphisms .
18544910	0	NAT2	34,38	N-acetyltransferase_2	11,32	NAT2	N-acetyltransferase 2	10	10	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of N-acetyltransferase_2 -LRB- NAT2 -RRB- , CYP2E1 and Glutathione-S-transferase -LRB- GST -RRB- genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients .
26700672	0	NAT2	94,98	N-acetyltransferase_2	71,92	NAT2	N-acetyltransferase 2	10	10	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Active cigarette smoking and the risk of breast_cancer at the level of N-acetyltransferase_2 -LRB- NAT2 -RRB- gene polymorphisms .
16906563	0	NAT2	54,58	NAT1	48,52	NAT2	NAT1	10	9	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Risk of limb deficiency_defects associated with NAT1 , NAT2 , GSTT1 , GSTM1 , and NOS3 genetic variants , maternal smoking , and vitamin supplement intake .
18986377	0	NAT2	69,73	NQO1	63,67	NAT2	NQO1	10	1728	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20373852	0	NAT2	96,100	NQO1	90,94	NAT2	NQO1	10	1728	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
18986377	0	NAT2	69,73	PRSS1	80,85	NAT2	PRSS1	10	5644	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
8144033	0	NAT2	57,61	Polymorphic_arylamine_N-acetyltransferase	0,41	NAT2	Polymorphic arylamine N-acetyltransferase	101840555	101840555	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphic_arylamine_N-acetyltransferase encoding gene -LRB- NAT2 -RRB- from homozygous rapid and slow acetylator congenic Syrian_hamsters .
26212654	0	NAV3	18,22	miR-29c	0,7	NAV3	miR-29c	260315(Tax:10090)	387224(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer * _ s_disease .
17244676	0	NB1	0,3	proteinase_3	52,64	NB1	proteinase 3	57126	5657	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	NB1 mediates surface expression of the ANCA antigen proteinase_3 on human neutrophils .
15238147	0	NB1_gp	18,24	CD177	11,16	NB1 gp	CD177	57126	57126	Gene	Gene	increased|dep|START_ENTITY increased|nsubjpass|END_ENTITY	Neutrophil CD177 -LRB- NB1_gp , HNA-2a -RRB- expression is increased in severe bacterial_infections_and_polycythaemia_vera .
9618176	0	NB4S	0,4	TBC1	22,26	NB4S	TBC1	7813	23216	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	NB4S , a member of the TBC1 domain family of genes , is truncated as a result of a constitutional t -LRB- 1 ; 10 -RRB- -LRB- p22 ; q21 -RRB- chromosome translocation in a patient with stage 4S neuroblastoma .
26578240	0	NBAS	34,38	Neuroblastoma_Amplified_Sequence	0,32	NBAS	Neuroblastoma Amplified Sequence	51594	51594	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Neuroblastoma_Amplified_Sequence -LRB- NBAS -RRB- mutation in recurrent_acute_liver_failure : Confirmatory report in a sibship with very early onset , osteoporosis and developmental_delay .
14733916	0	NBC1	40,44	SLC4A4	46,52	NBC1	SLC4A4	84484(Tax:10116)	84484(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of electrogenic NBC1 -LRB- SLC4A4 -RRB- variants in rat kidney and pancreas .
10876088	0	NBC1	37,41	kNBC1	48,53	NBC1	kNBC1	8671	8671	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Structural organization of the human NBC1 gene : kNBC1 is transcribed from an alternative promoter in intron 3 .
16687407	0	NBCe1-A	102,109	carbonic_anhydrase_II	16,37	NBCe1-A	carbonic anhydrase II	8671	760	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Effect of human carbonic_anhydrase_II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes .
23183381	0	NBCn1	22,27	PSD-95	0,6	NBCn1	PSD-95	9497	1742	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO -LRB- 3 -RRB- _ cotransport .
19995712	0	NBL1	0,4	ANLN	18,22	NBL1	ANLN	4681	54443	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	NBL1 and anillin -LRB- ANLN -RRB- genes over-expression in pancreatic_carcinoma .
10767562	0	NBP1	0,4	Nap1	6,10	NBP1	Nap1	851180(Tax:4932)	853922(Tax:4932)	Gene	Gene	START_ENTITY|dep|protein protein|amod|END_ENTITY	NBP1 -LRB- Nap1 binding protein 1 -RRB- , an essential gene for G2/M transition of Saccharomyces_cerevisiae , encodes a protein of distinct sub-nuclear localization .
11856312	0	NBR1	0,4	fasciculation_and_elongation_protein_zeta-1	20,63	NBR1	fasciculation and elongation protein zeta-1	17966(Tax:10090)	235180(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	NBR1 interacts with fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- and calcium_and_integrin_binding_protein -LRB- CIB -RRB- and shows developmentally restricted expression in the neural tube .
19398892	0	NBR1	0,4	p62	21,24	NBR1	p62	4077	8878	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets .
17672843	0	NBS1	0,4	ATM	65,68	NBS1	ATM	821254(Tax:3702)	823975(Tax:3702)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	NBS1 is involved in DNA repair and plays a synergistic role with ATM in mediating meiotic homologous recombination in plants .
18644472	0	NBS1	0,4	Bax	49,52	NBS1	Bax	4683	581	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	NBS1 regulates a novel apoptotic pathway through Bax activation .
24141789	0	NBS1	14,18	FOXM1	0,5	NBS1	FOXM1	4683	2305	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance .
18793719	0	NBS1	0,4	IGF-1	21,26	NBS1	IGF-1	4683	3479	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	NBS1 is required for IGF-1 induced cellular proliferation through the Ras/Raf/MEK / ERK cascade .
21297581	0	NBS1	82,86	L1CAM	0,5	NBS1	L1CAM	4683	3897	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1 .
18678890	0	NBS1	53,57	MDC1	0,4	NBS1	MDC1	4683	9656	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks .
12734548	0	NBS1	81,85	Nijmegen_Breakage_Syndrome	53,79	NBS1	Nijmegen Breakage Syndrome	4683	4683	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Multiplex single-tube screening for mutations in the Nijmegen_Breakage_Syndrome -LRB- NBS1 -RRB- gene in Hodgkin 's and non-Hodgkin 's _ lymphoma patients of Slavic origin .
18724061	0	NBS1	69,73	Nijmegen_breakage_syndrome	0,26	NBS1	Nijmegen breakage syndrome	4683	4683	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Nijmegen_breakage_syndrome and functions of the responsible protein , NBS1 .
24510842	0	NBS1	58,62	Nijmegen_breakage_syndrome	30,56	NBS1	Nijmegen breakage syndrome	4683	4683	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The prognostic impact of high Nijmegen_breakage_syndrome -LRB- NBS1 -RRB- gene expression in ERG-negative prostate_cancers lacking PTEN deletion is driven by KPNA2 expression .
21884979	0	NBS1	0,4	RAD18	14,19	NBS1	RAD18	4683	56852	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol - dependent translesion DNA synthesis .
26258880	0	NC2	63,66	TBP	55,58	NC2	TBP	1810	6908	Gene	Gene	START_ENTITY|nsubj|basis basis|nmod|END_ENTITY	Structural basis for recognition and remodeling of the TBP : DNA : NC2 complex by Mot1 .
18048413	0	NC2	41,44	TFIIB	20,25	NC2	TFIIB	1810	2959	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	The dual control of TFIIB recruitment by NC2 is gene specific .
15509807	0	NC2alpha	0,8	BTAF1	24,29	NC2alpha	BTAF1	10589	9044	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding_protein .
6991029	0	NCA	12,15	nonspecific_cross-reacting_antigen	17,51	NCA	nonspecific cross-reacting antigen	1084	1084	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of NCA -LRB- nonspecific_cross-reacting_antigen -RRB- in the cells of the human granulocyte series .
27027352	0	NCALD	120,125	LSD1	85,89	NCALD	LSD1	83988	23028	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Upregulation of long intergenic noncoding RNA 00673 promotes tumor proliferation via LSD1 interaction and repression of NCALD in non-small-cell_lung_cancer .
11267673	0	NCALD	85,90	neurocalcin_delta	61,78	NCALD	neurocalcin delta	83988	83988	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning , mapping and characterization of the human neurocalcin_delta gene -LRB- NCALD -RRB- .
10091945	0	NCAM	5,9	CD56	0,4	NCAM	CD56	4684	4684	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	CD56 -LRB- NCAM -RRB- antigen in glandular epithelium of human thyroid : light microscopic and ultrastructural study .
23292839	0	NCAM	14,18	CD56	20,24	NCAM	CD56	4684	4684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of NCAM -LRB- CD56 -RRB- , chromogranin_A , synaptophysin , c-KIT -LRB- CD117 -RRB- and PDGFRA in normal non-neoplastic skin and basal_cell_carcinoma : an immunohistochemical study of 66 consecutive cases .
25889612	0	NCAM	0,4	CD56	6,10	NCAM	CD56	4684	4684	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	NCAM -LRB- CD56 -RRB- Expression in keratin-producing odontogenic cysts : aberrant expression in KCOT .
25889612	0	NCAM	0,4	CD56	6,10	NCAM	CD56	4684	4684	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	NCAM -LRB- CD56 -RRB- Expression in keratin-producing odontogenic cysts : aberrant expression in KCOT .
7532919	0	NCAM	33,37	CD56	27,31	NCAM	CD56	4684	4684	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Clinicopathologic study of CD56 -LRB- NCAM -RRB- - positive angiocentric_lymphoma occurring in sites other than the upper and lower respiratory tract .
12743109	0	NCAM	31,35	Neural_cell_adhesion_molecule	0,29	NCAM	Neural cell adhesion molecule	4684	4684	Gene	Gene	association|appos|START_ENTITY association|amod|END_ENTITY	Neural_cell_adhesion_molecule -LRB- NCAM -RRB- association with PKCbeta2 via betaI_spectrin is implicated in NCAM-mediated neurite outgrowth .
18213713	0	NCAM	31,35	Neural_cell_adhesion_molecule	0,29	NCAM	Neural cell adhesion molecule	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Neural_cell_adhesion_molecule -LRB- NCAM -RRB- isoform expression is associated with neuroblastoma differentiation status .
17640175	0	NCAM	46,50	Neurotrophins_3_and_4	0,21	NCAM	Neurotrophins 3 and 4	24586(Tax:10116)	81737;25730	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Neurotrophins_3_and_4 differentially regulate NCAM , L1 and N-cadherin expression during peripheral nerve regeneration .
10216227	0	NCAM	45,49	OTX2	30,34	NCAM	OTX2	17967(Tax:10090)	18424(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The mouse homeodomain protein OTX2 regulates NCAM promoter activity .
15851519	0	NCAM	45,49	Prion_protein	0,13	NCAM	Prion protein	4684	5621	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Prion_protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth .
10222420	0	NCAM	161,165	neural_cell_adhesion_molecule	130,159	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Paucity of retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- nuclear immunostaining in gliomas and inability of retinoic_acid to influence neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression .
12502709	0	NCAM	61,65	neural_cell_adhesion_molecule	30,59	NCAM	neural cell adhesion molecule	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	ligand|appos|START_ENTITY ligand|nmod|END_ENTITY	A synthetic peptide ligand of neural_cell_adhesion_molecule -LRB- NCAM -RRB- , C3d , promotes neuritogenesis and synaptogenesis and modulates presynaptic function in primary cultures of rat hippocampal neurons .
1336835	0	NCAM	54,58	neural_cell_adhesion_molecule	23,52	NCAM	neural cell adhesion molecule	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gradient expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- in the pontine migratory stream of fetal rats .
1373000	0	NCAM	52,56	neural_cell_adhesion_molecule	21,50	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A supportive role of neural_cell_adhesion_molecule -LRB- NCAM -RRB- in adhesion between leukaemic blasts and cytotoxic lymphocytes .
1560678	0	NCAM	49,53	neural_cell_adhesion_molecule	18,47	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- on the haemopoietic cell line Nalm-16 .
1811057	0	NCAM	51,55	neural_cell_adhesion_molecule	20,49	NCAM	neural cell adhesion molecule	428253(Tax:9031)	428253(Tax:9031)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- during heart development .
1856291	0	NCAM	45,49	neural_cell_adhesion_molecule	14,43	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- isoforms in neuroblastoma .
18706130	0	NCAM	158,162	neural_cell_adhesion_molecule	127,156	NCAM	neural cell adhesion molecule	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression in the hippocampus of rats .
19741142	0	NCAM	90,94	neural_cell_adhesion_molecule	59,88	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Role of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- - neural_cell_adhesion_molecule -LRB- NCAM -RRB- interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF .
1974882	0	NCAM	108,112	neural_cell_adhesion_molecule	77,106	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic linkage of the human apolipoprotein AI-CIII-AIV gene cluster and the neural_cell_adhesion_molecule -LRB- NCAM -RRB- gene .
20003620	0	NCAM	43,47	neural_cell_adhesion_molecule	12,41	NCAM	neural cell adhesion molecule	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- in amygdalo-hippocampal interactions and salience determination of contextual fear memory .
2121537	0	NCAM	61,65	neural_cell_adhesion_molecule	31,60	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Differential expression of the neural_cell_adhesion_molecule NCAM 140 in human pituitary_tumors .
23377853	0	NCAM	68,72	neural_cell_adhesion_molecule	37,66	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of serine 774 of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- is involved in the interaction with collapsin_response_mediator_protein-2 .
2786812	0	NCAM	75,79	neural_cell_adhesion_molecule	44,73	NCAM	neural cell adhesion molecule	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmentally regulated expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- by mouse thymocytes .
3525283	0	NCAM	44,48	neural_cell_adhesion_molecule	13,42	NCAM	neural cell adhesion molecule	397762(Tax:8355)	397762(Tax:8355)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of neural_cell_adhesion_molecule -LRB- NCAM -RRB- in Xenopus embryos .
7527744	0	NCAM	51,55	neural_cell_adhesion_molecule	20,49	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Characterization of neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression in thyroid follicular cells : induction by cytokines and over-expression in autoimmune glands .
7577443	0	NCAM	58,62	neural_cell_adhesion_molecule	27,56	NCAM	neural cell adhesion molecule	428253(Tax:9031)	428253(Tax:9031)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- during osteogenesis and secondary chondrogenesis in the embryonic chick .
7833118	0	NCAM	61,65	neural_cell_adhesion_molecule	30,59	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Tissue-specific expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- may allow differential diagnosis of neuroblastoma from embryonal_rhabdomyosarcoma .
7842299	0	NCAM	49,53	neural_cell_adhesion_molecule	18,47	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- in Alzheimer 's _ disease .
8121388	0	NCAM	50,54	neural_cell_adhesion_molecule	19,48	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	-LSB- The expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- , neural_invasion and recurrence patterns in rectal_cancer -- a study using anti-NACM -LRB- neural_cell_adhesion_molecule -RRB- antibody -RSB- .
8214621	0	NCAM	49,53	neural_cell_adhesion_molecule	18,47	NCAM	neural cell adhesion molecule	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- during second - and third-molar development in the mouse .
8313157	0	NCAM	54,58	neural_cell_adhesion_molecule	23,52	NCAM	neural cell adhesion molecule	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Age-related changes in neural_cell_adhesion_molecule -LRB- NCAM -RRB- isoforms in the mouse telencephalon .
8470821	0	NCAM	45,49	neural_cell_adhesion_molecule	14,43	NCAM	neural cell adhesion molecule	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- during the first molar development in the mouse .
8605739	0	NCAM	14,18	neural_cell_adhesion_molecule	20,49	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of NCAM -LRB- neural_cell_adhesion_molecule -RRB- in mitochondrial_myopathy .
9045989	0	NCAM	51,55	neural_cell_adhesion_molecule	20,49	NCAM	neural cell adhesion molecule	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- during pre - and postnatal development of mouse incisors .
9215735	0	NCAM	45,49	neural_cell_adhesion_molecule	14,43	NCAM	neural cell adhesion molecule	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- characterizes a subpopulation of type 1 astrocytes in human optic nerve head .
9215732	0	NCAM	58,62	tenascin-C	11,21	NCAM	tenascin-C	4684	3371	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of tenascin-C in cultured hippocampal astrocytes : NCAM and fibronectin immunoreactivity changes .
15883837	0	NCAM1	50,55	neural_cell_adhesion_molecule_1	12,43	NCAM1	neural cell adhesion molecule 1	4684	4684	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SNPs in the neural_cell_adhesion_molecule_1 gene -LRB- NCAM1 -RRB- may be associated with human neural_tube_defects .
20483466	0	NCAM1	46,51	neuronal_cell_adhesion_molecule	13,44	NCAM1	neuronal cell adhesion molecule	4897	4897	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of neuronal_cell_adhesion_molecule -LRB- NCAM1 -RRB- variants on suicidal behaviour and correlated traits .
9226371	0	NCAM2	61,66	neural_cell_adhesion_molecule	25,54	NCAM2	neural cell adhesion molecule	4685	4684	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning of a novel human neural_cell_adhesion_molecule gene -LRB- NCAM2 -RRB- that maps to chromosome region 21q21 and is potentially involved in Down syndrome .
10772875	0	NCF1	41,45	p47-phox	31,39	NCF1	p47-phox	653361	653361	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure of the human p47-phox -LRB- NCF1 -RRB- gene .
11166463	0	NCF1	155,159	p47-phox	140,148	NCF1	p47-phox	653361	653361	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of patients with p47-phox-deficient chronic_granulomatous_disease : The significance of recombination events between the p47-phox gene -LRB- NCF1 -RRB- and its highly homologous pseudogenes .
19624736	0	NCF2	15,19	NCF2	77,81	NCF2	NCF2	100540644	100540644	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|mutations mutations|compound|END_ENTITY	Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutations .
19624736	0	NCF2	77,81	NCF2	15,19	NCF2	NCF2	100540644	100540644	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|mutations mutations|compound|END_ENTITY	Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutations .
17803907	0	NCK	90,93	SOCS7	106,111	NCK	SOCS7	4690	30837	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7 .
10320357	0	NCKX1	138,143	NCKX1	84,89	NCKX1	NCKX1	9187	9187	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|nmod|END_ENTITY	cDNA cloning and functional expression of the dolphin retinal rod Na-Ca + K exchanger NCKX1 : comparison with the functionally silent bovine NCKX1 .
10320357	0	NCKX1	84,89	NCKX1	138,143	NCKX1	NCKX1	9187	9187	Gene	Gene	expression|nmod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	cDNA cloning and functional expression of the dolphin retinal rod Na-Ca + K exchanger NCKX1 : comparison with the functionally silent bovine NCKX1 .
25472266	0	NCKX3	76,81	PMCA1	69,74	NCKX3	PMCA1	94249(Tax:10090)	67972(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	NCKX3	76,81	TRPV5	55,60	NCKX3	TRPV5	94249(Tax:10090)	194352(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	NCKX3	76,81	TRPV6	62,67	NCKX3	TRPV6	94249(Tax:10090)	64177(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
23224873	0	NCKX5	0,5	MC1R	105,109	NCKX5	MC1R	283652	4157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	NCKX5 , a natural regulator of human skin colour variation , regulates the expression of key pigment genes MC1R and alpha-MSH and alters cholesterol homeostasis in normal human melanocytes .
17939029	0	NCOR1	45,50	nuclear_receptor_co-repressor_1	12,43	NCOR1	nuclear receptor co-repressor 1	100037950(Tax:9823)	100037950(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The porcine nuclear_receptor_co-repressor_1 -LRB- NCOR1 -RRB- gene : chromosome location , expression profile , and polymorphism .
25074811	0	NCS-1	59,64	Ric8a	28,33	NCS-1	Ric8a	23413	60626	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The guanine-exchange factor Ric8a binds the calcium sensor NCS-1 to regulate synapse number and probability of release .
7591845	0	NCS-1	63,68	neural_calcium-binding_proteins	30,61	NCS-1	neural calcium-binding proteins	396336(Tax:9031)	396336(Tax:9031)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Distribution pattern of three neural_calcium-binding_proteins -LRB- NCS-1 , VILIP and recoverin -RRB- in chicken , bovine and rat retina .
12496348	0	NCS-1	44,49	neuronal_calcium_sensor-1	17,42	NCS-1	neuronal calcium sensor-1	23413	23413	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of neuronal_calcium_sensor-1 -LRB- NCS-1 -RRB- in the prefrontal cortex of schizophrenic and bipolar patients .
14760944	0	NCS-1	74,79	neuronal_calcium_sensor-1	47,72	NCS-1	neuronal calcium sensor-1	23413	23413	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Identification and subcellular localization of neuronal_calcium_sensor-1 -LRB- NCS-1 -RRB- in human neutrophils and HL-60 cells .
23990893	0	NCX	125,128	NCX1	72,76	NCX	NCX1	29715(Tax:10116)	29715(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY cells|nummod|END_ENTITY	Molecular strategy to reduce in vivo collagen barrier promotes entry of NCX1 positive inducible pluripotent stem cells -LRB- iPSC -LRB- NCX -RRB- -RRB- into ischemic -LRB- or injured -RRB- myocardium .
26421717	0	NCX1	55,59	Calmodulin	0,10	NCX1	Calmodulin	6546	808	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	Calmodulin Interacts with the Sodium/Calcium Exchanger NCX1 to Regulate Activity .
21928827	0	NCX1	36,40	Mg2	47,50	NCX1	Mg2	6546	4589	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The second Ca -LRB- 2 + -RRB- - binding domain of NCX1 binds Mg2 + with high affinity .
23990893	0	NCX1	72,76	NCX	125,128	NCX1	NCX	29715(Tax:10116)	29715(Tax:10116)	Gene	Gene	cells|nummod|START_ENTITY cells|appos|END_ENTITY	Molecular strategy to reduce in vivo collagen barrier promotes entry of NCX1 positive inducible pluripotent stem cells -LRB- iPSC -LRB- NCX -RRB- -RRB- into ischemic -LRB- or injured -RRB- myocardium .
25582710	0	NCX1	76,80	XIP	62,65	NCX1	XIP	6546	10542	Gene	Gene	Domain|nmod|START_ENTITY Domain|compound|END_ENTITY	A New Cell-penetrating Peptide That Blocks the Autoinhibitory XIP Domain of NCX1 and Enhances Antiporter Activity .
23069678	0	NCX1	0,4	rest	14,18	NCX1	rest	6546	5978	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	NCX1 is a new rest target gene : role in cerebral_ischemia .
12890497	0	NCoR	21,25	CHD1	0,4	NCoR	CHD1	9611	1105	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	CHD1 associates with NCoR and histone_deacetylase as well as with RNA splicing proteins .
10598586	0	NCoR	81,85	ER	43,45	NCoR	ER	9611	2099	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	A fusion protein of the estrogen_receptor -LRB- ER -RRB- and nuclear_receptor_corepressor -LRB- NCoR -RRB- strongly inhibits estrogen-dependent responses in breast_cancer cells .
19414341	0	NCoR	47,51	nuclear_receptor_corepressor	17,45	NCoR	nuclear receptor corepressor	9611	9611	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of nuclear_receptor_corepressor -LRB- NCoR -RRB- in progestin-induced growth suppression of endometrial_hyperplasia_and_carcinoma .
25904941	0	ND1	132,135	NADH_Dehydrogenase_I	110,130	ND1	NADH Dehydrogenase I	4535	4535	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Molecular Differentiation of Fasciola Species and Characterization of Genetic Diversity of F. gigantica Using NADH_Dehydrogenase_I -LRB- ND1 -RRB- Gene in the Endemic Areas of Iran .
18396045	0	ND5	22,25	MTND5	27,32	ND5	MTND5	4540	4540	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A novel mitochondrial ND5 -LRB- MTND5 -RRB- gene mutation giving isolated exercise intolerance .
17060449	0	NDEL1	0,5	Aurora-A_kinase	25,40	NDEL1	Aurora-A kinase	81565	6790	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	NDEL1 phosphorylation by Aurora-A_kinase is essential for centrosomal maturation , separation , and TACC3 recruitment .
10354494	0	NDI1	150,154	NADH-quinone_oxidoreductase	121,148	NDI1	NADH-quinone oxidoreductase	854919(Tax:4932)	854919(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Modulation of oxidative phosphorylation of human kidney 293 cells by transfection with the internal rotenone-insensitive NADH-quinone_oxidoreductase -LRB- NDI1 -RRB- gene of Saccharomyces_cerevisiae .
10982813	0	NDI1	40,44	NADH-quinone_oxidoreductase	11,38	NDI1	NADH-quinone oxidoreductase	854919(Tax:4932)	854919(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Use of the NADH-quinone_oxidoreductase -LRB- NDI1 -RRB- gene of Saccharomyces_cerevisiae as a possible cure for complex I defects in human cells .
11479321	0	NDI1	165,169	NADH-quinone_oxidoreductase	136,163	NDI1	NADH-quinone oxidoreductase	854919(Tax:4932)	854919(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces_cerevisiae NADH-quinone_oxidoreductase -LRB- NDI1 -RRB- gene .
10466793	0	NDK	65,68	env	17,20	NDK	env	4833	155971(Tax:11676)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Mutations in the env gene of human_immunodeficiency_virus_type_1 NDK isolates and the use of African_green_monkey CXCR4 as a co-receptor in COS-7 cells .
19770275	0	NDM-1	59,64	metallo-beta-lactamase	26,48	NDM-1	metallo-beta-lactamase	13914125	11934636	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a new metallo-beta-lactamase gene , bla -LRB- NDM-1 -RRB- , and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella_pneumoniae sequence type 14 from India .
15669020	0	NDN	46,49	necdin	51,57	NDN	necdin	4692	4692	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromatin modification of the human imprinted NDN -LRB- necdin -RRB- gene detected by in vivo footprinting .
9354807	0	NDN	23,26	necdin	10,16	NDN	necdin	4692	17984(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human necdin gene , NDN , is maternally imprinted and located in the Prader-Willi_syndrome chromosomal region .
20969804	0	NDNF	74,78	neuron-derived_neurotrophic_factor	38,72	NDNF	neuron-derived neurotrophic factor	68169(Tax:10090)	68169(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Spatio-temporal expression of a novel neuron-derived_neurotrophic_factor -LRB- NDNF -RRB- in mouse brains during development .
25234227	0	NDPK	80,84	nucleoside_diphosphate_kinase	49,78	NDPK	nucleoside diphosphate kinase	129607	129607	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Modulation of cytoskeletal dynamics by mammalian nucleoside_diphosphate_kinase -LRB- NDPK -RRB- proteins .
7542225	0	NDPK-A	13,19	nm23-H1	5,12	NDPK-A	nm23-H1	4830	4830	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	High nm23-H1 / NDPK-A expression in Ewing_tumors : paradoxical immunohistochemical reactivity and lack of prognostic significance .
24395206	0	NDPKA	34,39	Erythropoietin	0,14	NDPKA	Erythropoietin	4830	2056	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Erythropoietin increases neuronal NDPKA expression , and NDPKA up-regulation as well as exogenous application protects cortical neurons from in vitro ischemia-related insults .
8217603	0	NDP_kinase_alpha	25,41	nm23-2	18,24	NDP kinase alpha	nm23-2	191575(Tax:10116)	83782(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Expression of the nm23-2 / NDP_kinase_alpha gene in rat mammary and oral_carcinoma cells of varying metastatic potential .
1851361	0	NDPase	26,32	Nucleoside_diphosphatase	0,24	NDPase	Nucleoside diphosphatase	957	957	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Nucleoside_diphosphatase -LRB- NDPase -RRB- activity associated with human beta-protein amyloid fibers .
26057687	0	NDR1	14,18	PLK1	31,35	NDR1	PLK1	10397	5347	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis .
17012600	0	NDR1	0,4	RIN4	22,26	NDR1	RIN4	821607(Tax:3702)	822098(Tax:3702)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	NDR1 interaction with RIN4 mediates the differential activation of multiple disease resistance pathways in Arabidopsis .
24568526	0	NDR1/2	78,84	p21	114,117	NDR1/2	p21	11329;23012	1026	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Asiatic_acid promotes p21 -LRB- WAF1/CIP1 -RRB- protein stability through attenuation of NDR1/2 dependent phosphorylation of p21 -LRB- WAF1 / CIP1 -RRB- in HepG2 human hepatoma cells .
26852918	0	NDRG1	36,41	Aryl_Hydrocarbon_Receptor	0,25	NDRG1	Aryl Hydrocarbon Receptor	10397	196	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Aryl_Hydrocarbon_Receptor Activates NDRG1 Transcription under Hypoxia in Breast_Cancer Cells .
23526365	0	NDRG1	20,25	HIF-1a	0,6	NDRG1	HIF-1a	10397	3091	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	HIF-1a up-regulates NDRG1 expression through binding to NDRG1 promoter , leading to proliferation of lung_cancer A549 cells .
23813961	0	NDRG1	0,5	LDL_receptor	19,31	NDRG1	LDL receptor	17988(Tax:10090)	16835(Tax:10090)	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	NDRG1 functions in LDL_receptor trafficking by regulating endosomal recycling and degradation .
18455888	0	NDRG1	35,40	Myc	46,49	NDRG1	Myc	10397	4609	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region .
20582309	0	NDRG1	53,58	N-myc_downstream_regulated_gene_1	18,51	NDRG1	N-myc downstream regulated gene 1	482049(Tax:9615)	482049(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A deletion in the N-myc_downstream_regulated_gene_1 -LRB- NDRG1 -RRB- gene in Greyhounds with polyneuropathy .
21784644	0	NDRG1	49,54	N-myc_downstream_regulated_gene_1	14,47	NDRG1	N-myc downstream regulated gene 1	10397	10397	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of N-myc_downstream_regulated_gene_1 -LRB- NDRG1 -RRB- in central_neurocytoma .
22462691	0	NDRG1	41,46	NEDD4L	55,61	NDRG1	NEDD4L	10397	23327	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The iron-regulated metastasis suppressor NDRG1 targets NEDD4L , PTEN , and SMAD4 and inhibits the PI3K and Ras signaling pathways .
20348948	0	NDRG1	18,23	T-box_2	0,7	NDRG1	T-box 2	10397	6909	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	T-box_2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast_cancer cells .
26324937	0	NDRG1	0,5	p53	12,15	NDRG1	p53	10397	7157	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability .
26324937	0	NDRG1	0,5	p53	12,15	NDRG1	p53	10397	7157	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability .
23900729	0	NDRG2	0,5	E-cadherin	27,37	NDRG2	E-cadherin	57447	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon_cancer patients .
22346774	0	NDRG2	0,5	GATA-1	15,21	NDRG2	GATA-1	57447	2623	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NDRG2 Promotes GATA-1 Expression through Regulation of the JAK2/STAT Pathway in PMA-stimulated U937 Cells .
18209490	0	NDRG2	0,5	HIF-1	15,20	NDRG2	HIF-1	57447	3091	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells .
26646663	0	NDRG2	53,58	N-myc_downstream-regulated_gene	18,49	NDRG2	N-myc downstream-regulated gene	57447	57447	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Low expression of N-myc_downstream-regulated_gene 2 -LRB- NDRG2 -RRB- correlates with poor prognosis in hepatoblastoma .
26506239	0	NDRG2	52,57	N-myc_downstream-regulated_gene_2	17,50	NDRG2	N-myc downstream-regulated gene 2	57447	57447	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Emerging role of N-myc_downstream-regulated_gene_2 -LRB- NDRG2 -RRB- in cancer .
14572661	0	NDRG2	29,34	N-myc_downstream_regulated_gene_2	36,69	NDRG2	N-myc downstream regulated gene 2	57447	57447	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of NDRG2 -LRB- N-myc_downstream_regulated_gene_2 -RRB- during the differentiation of dendritic cells .
17050536	0	NDRG2	118,123	NDRG2	53,58	NDRG2	NDRG2	57447	57447	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter .
17050536	0	NDRG2	53,58	NDRG2	118,123	NDRG2	NDRG2	57447	57447	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter .
23884416	0	NDST1	63,68	MicroRNA-24	0,11	NDST1	MicroRNA-24	3340	407012	Gene	Gene	suppression|appos|START_ENTITY suppression|amod|END_ENTITY	MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase -1 -LRB- NDST1 -RRB- reduces endothelial cell responsiveness to vascular_endothelial_growth_factor_A -LRB- VEGFA -RRB- .
22100406	0	NDUFA4L2	31,39	HIF-1a	51,57	NDUFA4L2	HIF-1a	407790(Tax:10090)	15251(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Induction of the mitochondrial NDUFA4L2 protein by HIF-1a decreases oxygen consumption by inhibiting Complex I activity .
25470292	0	NDUFS6	21,27	CD147	0,5	NDUFS6	CD147	4726	682	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	CD147 Interacts with NDUFS6 in Regulating Mitochondrial Complex I Activity and the Mitochondrial Apoptotic Pathway in Human Malignant_Melanoma Cells .
10797259	0	NE-dlg	0,6	NE-dlg	183,189	NE-dlg	NE-dlg	1741	1741	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|amod|END_ENTITY	NE-dlg , a mammalian homolog of Drosophila dlg tumor suppressor , induces growth_suppression and impairment of cell adhesion : possible involvement of down-regulation of beta-catenin by NE-dlg expression .
10797259	0	NE-dlg	183,189	NE-dlg	0,6	NE-dlg	NE-dlg	1741	1741	Gene	Gene	expression|amod|START_ENTITY induces|nmod|expression induces|nsubj|END_ENTITY	NE-dlg , a mammalian homolog of Drosophila dlg tumor suppressor , induces growth_suppression and impairment of cell adhesion : possible involvement of down-regulation of beta-catenin by NE-dlg expression .
26822763	0	NEAT1	19,24	CDK6	92,96	NEAT1	CDK6	283131	1021	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Long noncoding RNA NEAT1 promotes laryngeal_squamous_cell_cancer through regulating miR-107 / CDK6 pathway .
26459763	0	NEAT1	51,56	miR-140	0,7	NEAT1	miR-140	66961(Tax:10090)	387158(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	miR-140 Promotes Expression of long non-coding RNA NEAT1 in Adipogenesis .
23443021	0	NEB	9,12	Nebulin	0,7	NEB	Nebulin	4703	4703	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Nebulin -LRB- NEB -RRB- mutations in a childhood onset distal_myopathy with rods and cores uncovered by next generation sequencing .
24056153	0	NEB	69,72	Nebulin	60,67	NEB	Nebulin	4703	4703	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Nemaline_Myopathy_Type_2 -LRB- NEM2 -RRB- : Two Novel Mutations in the Nebulin -LRB- NEB -RRB- Gene .
26304770	0	NEDD4	0,5	PAX7	16,20	NEDD4	PAX7	4734	5081	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors .
26006083	0	NEDD4-1	76,83	ABCB1	30,35	NEDD4-1	ABCB1	4734	5243	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1 .
26006083	0	NEDD4-1	76,83	ABCB1	30,35	NEDD4-1	ABCB1	4734	5243	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1 .
20332230	0	NEDD4-1	17,24	FoxM1B	0,6	NEDD4-1	FoxM1B	4734	2305	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FoxM1B regulates NEDD4-1 expression , leading to cellular transformation and full malignant phenotype in immortalized human astrocytes .
25542253	0	NEDD4-2	45,52	NEDD4L	54,60	NEDD4-2	NEDD4L	23327	23327	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Investigation of the possible association of NEDD4-2 -LRB- NEDD4L -RRB- gene with idiopathic photosensitive_epilepsy .
15496141	0	NEDD4-2	0,7	TGF-beta	99,107	NEDD4-2	TGF-beta	23327	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	NEDD4-2 -LRB- neural precursor cell expressed , developmentally down-regulated 4-2 -RRB- negatively regulates TGF-beta -LRB- transforming_growth_factor-beta -RRB- signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta_type_I_receptor .
22462691	0	NEDD4L	55,61	NDRG1	41,46	NEDD4L	NDRG1	23327	10397	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The iron-regulated metastasis suppressor NDRG1 targets NEDD4L , PTEN , and SMAD4 and inhibits the PI3K and Ras signaling pathways .
25542253	0	NEDD4L	54,60	NEDD4-2	45,52	NEDD4L	NEDD4-2	23327	23327	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Investigation of the possible association of NEDD4-2 -LRB- NEDD4L -RRB- gene with idiopathic photosensitive_epilepsy .
12694406	0	NEDD8	32,37	ASPP2	0,5	NEDD8	ASPP2	4738	7159	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis .
11585840	0	NEDD8	13,18	NUB1	69,73	NEDD8	NUB1	4738	51667	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 .
11953428	0	NEDD8	4,9	SCF	35,38	NEDD8	SCF	4738	4254	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	The NEDD8 pathway is essential for SCF -LRB- beta _ - TrCP -RRB- - mediated ubiquitination and processing of the NF-kappa B precursor p105 .
22370482	0	NEDD8	38,43	Ube1	24,28	NEDD8	Ube1	4738	7317	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions .
26260793	0	NEDD8_Ultimate_Buster_1	0,23	NUB1L	30,35	NEDD8 Ultimate Buster 1	NUB1L	51667	51667	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	NEDD8_Ultimate_Buster_1 Long -LRB- NUB1L -RRB- Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins .
25594051	1	NEDD9	67,72	CASS4	74,79	NEDD9	CASS4	4739	57091	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	The cancer signaling proteins NEDD9 , CASS4 , and PTK2B in Alzheimer 's _ disease .
22869051	0	NEDD9	0,5	miR-145	25,32	NEDD9	miR-145	4739	406937	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	NEDD9 , a novel target of miR-145 , increases the invasiveness of glioblastoma .
21108931	0	NEDL1	21,26	RNF43	0,5	NEDL1	RNF43	23072	54894	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RNF43 interacts with NEDL1 and regulates p53-mediated transcription .
14684739	0	NEDL1	0,5	superoxide_dismutase-1	85,107	NEDL1	superoxide dismutase-1	23072	6647	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	NEDL1 , a novel ubiquitin-protein isopeptide ligase for dishevelled-1 , targets mutant superoxide_dismutase-1 .
22650988	0	NEEP21	30,36	Calcyon	0,7	NEEP21	Calcyon	27065	68566(Tax:10090)	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Calcyon , a mammalian specific NEEP21 family member , interacts with adaptor protein complex 3 -LRB- AP-3 -RRB- and regulates targeting of AP-3 cargoes .
10388555	0	NEF	94,97	hck	150,153	NEF	hck	156110(Tax:11676)	15162(Tax:10090)	Gene	Gene	macrophages|nmod|START_ENTITY Induction|nmod|macrophages response|nsubj|Induction response|acl:relcl|requires requires|dobj|END_ENTITY	Induction of activator protein 1 -LRB- AP-1 -RRB- in macrophages by human_immunodeficiency_virus_type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events .
16734940	0	NEF3	63,67	dopamine_receptor_interacting_protein	19,56	NEF3	dopamine receptor interacting protein	4741	85406	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the dopamine_receptor_interacting_protein gene , NEF3 , with early response to antipsychotic medication .
14733962	0	NEFL	31,35	neurofilament_light	10,29	NEFL	neurofilament light	4747	4747	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	The novel neurofilament_light -LRB- NEFL -RRB- mutation Glu397Lys is associated with a clinically and morphologically heterogeneous type of Charcot-Marie-Tooth_neuropathy .
26977442	0	NEGR1	105,110	Neuronal_growth_regulator_1	76,103	NEGR1	Neuronal growth regulator 1	257194	257194	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Supporting data for characterization of non-coding RNAs associated with the Neuronal_growth_regulator_1 -LRB- NEGR1 -RRB- adhesion protein .
17611195	0	NEIL1	104,109	Werner_syndrome_protein	10,33	NEIL1	Werner syndrome protein	79661	7486	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	The human Werner_syndrome_protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1 .
15339932	0	NEIL2	52,57	Nei-like-2	59,69	NEIL2	Nei-like-2	252969	252969	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of a zinc finger domain in the human NEIL2 -LRB- Nei-like-2 -RRB- protein .
12063396	0	NEK3	88,92	NIMA-related_protein_kinase_3	52,81	NEK3	NIMA-related protein kinase 3	4752	4752	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and characterization of the human NIMA-related_protein_kinase_3 gene -LRB- NEK3 -RRB- .
20538601	0	NEL-like_2	40,50	NELL2	52,57	NEL-like 2	NELL2	54003(Tax:10090)	54003(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Estrogen-dependent transcription of the NEL-like_2 -LRB- NELL2 -RRB- gene and its role in protection from cell death .
15018815	0	NELF	29,33	Nasal_embryonic_LHRH_factor	0,27	NELF	Nasal embryonic LHRH factor	26012	26012	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Nasal_embryonic_LHRH_factor -LRB- NELF -RRB- expression within the CNS and PNS of the rodent .
24316376	0	NELF	56,60	nasal_embryonic_LHRH_factor	27,54	NELF	nasal embryonic LHRH factor	56876(Tax:10090)	56876(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of nasal_embryonic_LHRH_factor -LRB- NELF -RRB- variants in immortalized GnRH neuronal cell lines .
21723284	0	NELL-1	0,6	APR3	16,20	NELL-1	APR3	4745	51374	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation .
24563467	0	NELL1	95,100	Nel-like_molecule_1	74,93	NELL1	Nel-like molecule 1	338352(Tax:10090)	338352(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Oligomerization-induced conformational change in the C-terminal region of Nel-like_molecule_1 -LRB- NELL1 -RRB- protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading .
20538601	0	NELL2	52,57	NEL-like_2	40,50	NELL2	NEL-like 2	54003(Tax:10090)	54003(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Estrogen-dependent transcription of the NEL-like_2 -LRB- NELL2 -RRB- gene and its role in protection from cell death .
12617830	0	NELL2	55,60	neural_epidermal_growth_factor-like_like_2	11,53	NELL2	neural epidermal growth factor-like like 2	4753	4753	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Restricted neural_epidermal_growth_factor-like_like_2 -LRB- NELL2 -RRB- expression during muscle and neuronal differentiation .
14516654	0	NELL2	55,60	neural_epidermal_growth_factor-like_like_2	11,53	NELL2	neural epidermal growth factor-like like 2	4753	4753	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Restricted neural_epidermal_growth_factor-like_like_2 -LRB- NELL2 -RRB- expression during muscle and neuronal differentiation .
18287044	0	NEMO	0,4	Bcl10	34,39	NEMO	Bcl10	8517	8915	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation .
26060140	0	NEMO	18,22	COMMD7	0,6	NEMO	COMMD7	8517	149951	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	COMMD7 as a novel NEMO interacting protein involved in the termination of NF-kB signaling .
23097049	0	NEMO	60,64	Fibroblast_growth_factor_homologous_factor_1	0,44	NEMO	Fibroblast growth factor homologous factor 1	8517	2257	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fibroblast_growth_factor_homologous_factor_1 interacts with NEMO to regulate NF-kB signaling in neurons .
16333836	0	NEMO	31,35	IKK-gamma	37,46	NEMO	IKK-gamma	8517	8517	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel splicing mutation in the NEMO -LRB- IKK-gamma -RRB- gene with severe immunodeficiency and heterogeneity of X-chromosome inactivation .
11971901	0	NEMO	42,46	IKKbeta	59,66	NEMO	IKKbeta	8517	3551	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	Regulation of Ikappa_B_kinase _ -LRB- IKK -RRB- gamma / NEMO function by IKKbeta - mediated phosphorylation .
10755617	0	NEMO	80,84	RIP	60,63	NEMO	RIP	8517	8737	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	Recruitment of the IKK signalosome to the p55 TNF receptor : RIP and A20 bind to NEMO -LRB- IKKgamma -RRB- upon receptor stimulation .
23028469	0	NEMO	0,4	TANK-binding_kinase_1	25,46	NEMO	TANK-binding kinase 1	8517	29110	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	NEMO binds ubiquitinated TANK-binding_kinase_1 -LRB- TBK1 -RRB- to regulate innate immune responses to RNA viruses .
20970423	0	NEMO	0,4	c-Myc	16,21	NEMO	c-Myc	8517	4609	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	NEMO stabilizes c-Myc through direct interaction in the nucleus .
15164415	0	NEMO	58,62	incontinentia_pigmenti	80,102	NEMO	incontinentia pigmenti	8517	8517	Gene	Gene	rearrangement|compound|START_ENTITY rearrangement|nmod|END_ENTITY	A novel PCR approach for prenatal detection of the common NEMO rearrangement in incontinentia_pigmenti .
20652730	0	NEMO	72,76	nuclear_factor-kB_essential_modulator	33,70	NEMO	nuclear factor-kB essential modulator	8517	8517	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel missense mutation in the nuclear_factor-kB_essential_modulator -LRB- NEMO -RRB- gene resulting in impaired activation of the NF-kB pathway and a unique clinical phenotype presenting as MRSA subdural_empyema .
11312364	0	NEP	18,21	NS2	23,26	NEP	NEP	4311	4311	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Influenza_A_virus NEP -LRB- NS2 protein -RRB- downregulates RNA synthesis of model template RNAs .
11462009	0	NEP	24,27	NS2	29,32	NEP	NS2	4311	57762	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Influenza B and C_virus NEP -LRB- NS2 -RRB- proteins possess nuclear export activities .
9427762	0	NEP	20,23	NS2	25,28	NEP	NS2	4311	57762	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	The influenza virus NEP -LRB- NS2 protein -RRB- mediates the nuclear export of viral ribonucleoproteins .
15963503	0	NEP	37,40	neutral_endopeptidase	14,35	NEP	neutral endopeptidase	4311	4311	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of neutral_endopeptidase -LRB- NEP -RRB- facilitates neurogenic_inflammation .
16597367	0	NEP	36,39	neutral_endopeptidase	13,34	NEP	neutral endopeptidase	4311	4311	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Induction of neutral_endopeptidase -LRB- NEP -RRB- activity of SK-N-SH cells by natural compounds from green tea .
8575569	0	NEP	39,42	neutral_endopeptidase	16,37	NEP	neutral endopeptidase	4311	4311	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of neutral_endopeptidase -LRB- NEP -RRB- mRNA in human bronchi .
11416156	0	NEPH1	52,57	NEPHRIN	92,99	NEPH1	NEPHRIN	170643(Tax:10090)	54631(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY lacking|nmod|END_ENTITY	Proteinuria and perinatal lethality in mice lacking NEPH1 , a novel protein with homology to NEPHRIN .
11416156	0	NEPHRIN	92,99	NEPH1	52,57	NEPHRIN	NEPH1	54631(Tax:10090)	170643(Tax:10090)	Gene	Gene	lacking|nmod|START_ENTITY lacking|dobj|END_ENTITY	Proteinuria and perinatal lethality in mice lacking NEPH1 , a novel protein with homology to NEPHRIN .
15913957	0	NESK	27,31	JNK	9,12	NESK	JNK	203447	5599	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Enhanced JNK activation by NESK without kinase activity upon caspase-mediated cleavage during apoptosis .
17185044	0	NESP55	37,43	Neuroendocrine_secretory_protein_55	0,35	NESP55	Neuroendocrine secretory protein 55	24896(Tax:10116)	24896(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Neuroendocrine_secretory_protein_55 -LRB- NESP55 -RRB- immunoreactivity in male and female rat superior cervical ganglion and other sympathetic ganglia .
12401556	0	NET	33,36	Norepinephrine_transporter	0,26	NET	Norepinephrine transporter	6530	6530	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Norepinephrine_transporter gene -LRB- NET -RRB- variants in patients with panic_disorder .
15722184	0	NET	28,31	Norepinephrine_transporter	0,26	NET	Norepinephrine transporter	6530	6530	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Norepinephrine_transporter -LRB- NET -RRB- promoter and 5 ' - UTR polymorphisms : association analysis in panic_disorder .
21569456	0	NET	66,69	norepinephrine_transporter	33,59	NET	norepinephrine transporter	6530	6530	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The 1287_G / A polymorphism of the norepinephrine_transporter gene -LRB- NET -RRB- is involved in commission errors in Korean children with attention_deficit_hyperactivity_disorder .
25724484	0	NET	43,46	norepinephrine_transporter	15,41	NET	norepinephrine transporter	6530	6530	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of norepinephrine_transporter -LRB- NET , SLC6A2 -RRB- genotype with ADHD-related phenotypes : Findings of a longitudinal study from birth to adolescence .
15684429	0	NET1	66,70	PAK1	0,4	NET1	PAK1	10276	5058	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PAK1 negatively regulates the activity of the Rho exchange factor NET1 .
20547485	0	NET1	34,38	Smad3	0,5	NET1	Smad3	10276	4088	Gene	Gene	signaling|nmod|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	Smad3 regulates Rho signaling via NET1 in the transforming_growth_factor-beta-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells .
26991362	0	NETO1	49,54	GluK1	30,35	NETO1	GluK1	81832	2897	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Pharmacological Modulation of GluK1 and GluK2 by NETO1 , NETO2 , and PSD95 .
15888257	0	NEU	136,139	HER-2	130,135	NEU	HER-2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	A limited autoimmunity to p185neu elicited by DNA and allogeneic cell vaccine hampers the progression of preneoplastic_lesions in HER-2 / NEU transgenic_mice .
9307054	0	NEU	63,66	c-erbB2	55,62	NEU	c-erbB2	2064	2064	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Estrogens and glucocorticoids induce the expression of c-erbB2 / NEU receptor in Ishikawa human endometrial cells .
14695530	0	NEU1	54,58	lysosomal_sialidase	28,47	NEU1	lysosomal sialidase	4758	4758	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Five novel mutations in the lysosomal_sialidase gene -LRB- NEU1 -RRB- in type II_sialidosis patients and assessment of their impact on enzyme activity and intracellular targeting using adenovirus-mediated expression .
23391804	0	NEU1	40,44	neuraminidase-1	23,38	NEU1	neuraminidase-1	4758	4758	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations in the neuraminidase-1 -LRB- NEU1 -RRB- gene in two patients of sialidosis in India .
21036040	0	NEU3	37,41	neuraminidase_3	20,35	NEU3	neuraminidase 3	10825	10825	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human neuraminidase_3 -LRB- NEU3 -RRB- by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic _ acid .
19646530	0	NEUROG2	23,30	MTGR1	43,48	NEUROG2	MTGR1	63973	9139	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis .
11246894	0	NEUROG3	57,64	neurogenin_3	38,50	NEUROG3	neurogenin 3	50674	50674	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the coding region of the neurogenin_3 gene -LRB- NEUROG3 -RRB- are not a common cause of maturity-onset_diabetes_of_the_young in Japanese subjects .
24866383	0	NEXN	0,4	GATA4	14,19	NEXN	GATA4	68810(Tax:10090)	14463(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	NEXN inhibits GATA4 and leads to atrial_septal_defects in mice and humans .
12956740	0	NF-AT2	132,138	interleukin-13	40,54	NF-AT2	interleukin-13	4772	3596	Gene	Gene	expression|nmod|START_ENTITY correlates|nmod|expression correlates|amod|END_ENTITY	Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun_B : relevance to immunotherapy .
11154691	0	NF-E2	15,20	CREB-binding_protein	36,56	NF-E2	CREB-binding protein	4778	1387	Gene	Gene	DNA|compound|START_ENTITY DNA|amod|binding binding|nmod|END_ENTITY	Stimulation of NF-E2 DNA binding by CREB-binding_protein -LRB- CBP -RRB- - mediated acetylation .
9047395	0	NF-E2	15,20	c-Jun	0,5	NF-E2	c-Jun	18022(Tax:10090)	16476(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	c-Jun inhibits NF-E2 transcriptional activity in association with p18/maf in Friend erythroleukemia cells .
11463954	0	NF-E2	56,61	nuclear_factor-erythroid_2	28,54	NF-E2	nuclear factor-erythroid 2	4778	4778	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-4 downregulates nuclear_factor-erythroid_2 -LRB- NF-E2 -RRB- expression in primary megakaryocytes and in megakaryoblastic cell lines .
23526214	0	NF-E2-related_factor-2	95,117	migratory_inhibition_factor	8,35	NF-E2-related factor-2	migratory inhibition factor	18024(Tax:10090)	17319(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of migratory_inhibition_factor in age-related susceptibility to radiation_lung_injury via NF-E2-related_factor-2 and antioxidant regulation .
15521073	0	NF-E2-related_factor-2	115,137	thioredoxin_reductase_1	30,53	NF-E2-related factor-2	thioredoxin reductase 1	4780	7296	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional regulation of thioredoxin_reductase_1 expression by cadmium in vascular endothelial cells : role of NF-E2-related_factor-2 .
20309604	0	NF-E2-related_factor_2	0,22	CFTR	88,92	NF-E2-related factor 2	CFTR	4780	1080	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	NF-E2-related_factor_2 , a key inducer of antioxidant defenses , negatively regulates the CFTR transcription .
20427290	0	NF-E2-related_factor_2	43,65	CR6-interacting_factor_1	0,24	NF-E2-related factor 2	CR6-interacting factor 1	4780	90480	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	CR6-interacting_factor_1 -LRB- CRIF1 -RRB- regulates NF-E2-related_factor_2 -LRB- NRF2 -RRB- protein stability by proteasome-mediated degradation .
16962933	0	NF-E2-related_factor_2	75,97	HO-1	22,26	NF-E2-related factor 2	HO-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related_factor_2 in PC12 cells .
23043106	0	NF-E2-related_factor_2	101,123	Nrf2	125,129	NF-E2-related factor 2	Nrf2	18024(Tax:10090)	18024(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related_factor_2 -LRB- Nrf2 -RRB- activation .
26773873	0	NF-E2-related_factor_2	116,138	Nrf2	140,144	NF-E2-related factor 2	Nrf2	4780	4780	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	The novel triterpenoid_RTA_408 protects human retinal_pigment_epithelial cells against H2O2-induced cell injury via NF-E2-related_factor_2 -LRB- Nrf2 -RRB- activation .
15882976	0	NF-E2-related_factor_2	70,92	heme_oxygenase-1	24,40	NF-E2-related factor 2	heme oxygenase-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Resveratrol upregulates heme_oxygenase-1 expression via activation of NF-E2-related_factor_2 in PC12 cells .
19628634	0	NF-E2-related_factor_2	158,180	heme_oxygenase-1	123,139	NF-E2-related factor 2	heme oxygenase-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Lansoprazole , a proton pump inhibitor , mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme_oxygenase-1 via activation of NF-E2-related_factor_2 and oxidation of kelch-like_ECH-associating_protein_1 .
15790560	0	NF-E2_p45-related_factor	30,54	NRF2	56,60	NF-E2 p45-related factor	NRF2	18024(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transcriptional regulation of NF-E2_p45-related_factor -LRB- NRF2 -RRB- expression by the aryl_hydrocarbon_receptor-xenobiotic response element signaling pathway : direct cross-talk between phase I and II drug-metabolizing enzymes .
8662984	0	NF-H	68,72	Cdk5	77,81	NF-H	Cdk5	24587(Tax:10116)	140908(Tax:10116)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of the high molecular weight neurofilament protein -LRB- NF-H -RRB- by Cdk5 and p35 .
16954602	0	NF-H	32,36	Tpc1808	0,7	NF-H	Tpc1808	24587(Tax:10116)	64560(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Tpc1808 increases expression of NF-H in PC12 cells .
11034913	0	NF-H	55,59	neurofilament_protein-H	30,53	NF-H	neurofilament protein-H	4744	4744	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The C-terminal tail domain of neurofilament_protein-H -LRB- NF-H -RRB- forms the crossbridges and regulates neurofilament bundle formation .
17366569	0	NF-IL-6	41,48	NF-kappaB	77,86	NF-IL-6	NF-kappaB	1051	4790	Gene	Gene	IL-6|appos|START_ENTITY IL-6|appos|END_ENTITY	Activation of transcription factor IL-6 -LRB- NF-IL-6 -RRB- and nuclear factor-kappaB -LRB- NF-kappaB -RRB- by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells .
8264594	0	NF-IL6	48,54	Fos	0,3	NF-IL6	Fos	1051	2353	Gene	Gene	repress|nmod|START_ENTITY repress|nsubj|END_ENTITY	Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region .
7876106	0	NF-IL6	32,38	TSG-6	18,23	NF-IL6	TSG-6	1051	7130	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Activation of the TSG-6 gene by NF-IL6 requires two adjacent NF-IL6 binding sites .
17724128	0	NF-IL6	22,28	Trib1	58,63	NF-IL6	Trib1	12608(Tax:10090)	211770(Tax:10090)	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency .
10801783	0	NF-IL6	0,6	il1b	41,45	NF-IL6	il1b	1051	3553	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	NF-IL6 -LRB- C/EBPbeta -RRB- vigorously activates il1b gene expression via a Spi-1 _ -LRB- PU .1 -RRB- protein-protein tether .
10229861	0	NF-IL6	37,43	inducible_nitric_oxide_synthase	96,127	NF-IL6	inducible nitric oxide synthase	12608(Tax:10090)	18126(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible_nitric_oxide_synthase expression .
10226093	0	NF-IL6	87,93	interleukin-6	38,51	NF-IL6	interleukin-6	1051	3569	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-kappaB in primary human vascular smooth muscle cells .
1730090	0	NF-IL6	50,56	interleukin-6	85,98	NF-IL6	interleukin-6	1051	3569	Gene	Gene	expression|nmod|START_ENTITY expression|appos|factor factor|nmod|END_ENTITY	Macrophage differentiation-specific expression of NF-IL6 , a transcription factor for interleukin-6 .
8325885	0	NF-IL6	91,97	interleukin-6	24,37	NF-IL6	interleukin-6	1051	3569	Gene	Gene	activity|appos|START_ENTITY _|dobj|activity C/EBP|xcomp|_ C/EBP|nsubj|Modulation Modulation|nmod|promoter promoter|amod|END_ENTITY	Modulation of the human interleukin-6 promoter -LRB- IL-6 -RRB- and transcription factor C/EBP _ beta -LRB- NF-IL6 -RRB- activity by p53 species .
8441418	0	NF-IL6	47,53	interleukin-6	21,34	NF-IL6	interleukin-6	24253(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A nuclear factor for interleukin-6 expression -LRB- NF-IL6 -RRB- and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction .
8455626	0	NF-IL6	25,31	interleukin-6	55,68	NF-IL6	interleukin-6	1051	3569	Gene	Gene	regulation|nmod|START_ENTITY synthesis|nsubj|regulation synthesis|nmod|signaling signaling|amod|END_ENTITY	Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic_acid signaling in embryonal_carcinoma cells .
9199508	0	NF-IL6	134,140	interleukin-6	14,27	NF-IL6	interleukin-6	1051	3569	Gene	Gene	inhibition|amod|START_ENTITY Repression|dep|inhibition Repression|nmod|expression expression|amod|END_ENTITY	Repression of interleukin-6 gene expression by 17_beta-estradiol : inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa_B by the estrogen_receptor .
9461509	0	NF-IL6	34,40	interleukin-6	188,201	NF-IL6	interleukin-6	1051	3569	Gene	Gene	interleukin-6|appos|START_ENTITY pathways|nsubj|interleukin-6 pathways|xcomp|co-operate co-operate|xcomp|mediate mediate|advcl|END_ENTITY	The nuclear factor interleukin-6 -LRB- NF-IL6 -RRB- and signal_transducer_and_activator_of_transcription-3 -LRB- STAT-3 -RRB- signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat_shock .
7935377	0	NF-IL6	0,6	tumor_necrosis_factor_alpha	75,102	NF-IL6	tumor necrosis factor alpha	1051	7124	Gene	Gene	modulate|nsubj|START_ENTITY modulate|nmod|END_ENTITY	NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor_necrosis_factor_alpha and interleukin-1 .
16397300	0	NF-IL6beta	19,29	cyclooxygenase_2	106,122	NF-IL6beta	cyclooxygenase 2	1052	5743	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|amod|END_ENTITY	Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase_2 gene .
15217752	0	NF-KB	101,106	iNOS	55,59	NF-KB	iNOS	81736(Tax:10116)	24599(Tax:10116)	Gene	Gene	translocation|amod|START_ENTITY END_ENTITY|nmod|translocation	p38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells .
25250890	0	NF-Kappa_B	65,75	Angiotensin_II	0,14	NF-Kappa B	Angiotensin II	4790	183	Gene	Gene	Signaling|compound|START_ENTITY Expression|nmod|Signaling Expression|compound|END_ENTITY	Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25742014	0	NF-Kappa_B	77,87	Angiotensin_II	12,26	NF-Kappa B	Angiotensin II	4790	183	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Correction : Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25250890	0	NF-Kappa_B	65,75	Endothelial_Lipase	27,45	NF-Kappa B	Endothelial Lipase	4790	9388	Gene	Gene	Signaling|compound|START_ENTITY Expression|nmod|Signaling Expression|compound|END_ENTITY	Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
25742014	0	NF-Kappa_B	77,87	Endothelial_Lipase	39,57	NF-Kappa B	Endothelial Lipase	4790	9388	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Correction : Angiotensin_II Upregulates Endothelial_Lipase Expression via the NF-Kappa_B and MAPK Signaling Pathways .
15028764	0	NF-L	49,53	neurofilament	34,47	NF-L	neurofilament	18039(Tax:10090)	18039(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	3 ' untranslated region in a light neurofilament -LRB- NF-L -RRB- mRNA triggers aggregation of NF-L and mutant superoxide_dismutase_1 proteins in neuronal cells .
7477677	0	NF-L	50,54	neurofilament	35,48	NF-L	neurofilament	18039(Tax:10090)	18039(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of low-molecular-weight neurofilament -LRB- NF-L -RRB- mRNA during postnatal development of the mouse brain .
9189892	0	NF-L	56,60	neurofilament	41,54	NF-L	neurofilament	4747	4747	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Marked decrease of immunolabelled 68 kDa neurofilament -LRB- NF-L -RRB- proteins in brains of opiate addicts .
17120287	0	NF-M	85,89	neurofilament	70,83	NF-M	neurofilament	751981(Tax:59729)	751981(Tax:59729)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Enriched expression and developmental regulation of the middle-weight neurofilament -LRB- NF-M -RRB- gene in song control nuclei of the zebra_finch .
10426285	0	NF-M	111,115	peripherin	84,94	NF-M	peripherin	4741	5630	Gene	Gene	assembly|nmod|START_ENTITY assembly|compound|END_ENTITY	Interactions between peripherin and neurofilaments in cultured cells : disruption of peripherin assembly by the NF-M and NF-H subunits .
18069941	0	NF-X1	68,73	AtNFXL1	0,7	NF-X1	AtNFXL1	4799	837555(Tax:3702)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	AtNFXL1 , an Arabidopsis homologue of the human transcription factor NF-X1 , functions as a negative regulator of the trichothecene phytotoxin-induced defense response .
10998178	0	NF-X1	48,53	FAP1	0,4	NF-X1	FAP1	4799	5783	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	FAP1 , a homologue of human transcription factor NF-X1 , competes with rapamycin for binding to FKBP12 in yeast .
23576578	0	NF-kB	25,30	Angiotensin_II	0,14	NF-kB	Angiotensin II	309165(Tax:10116)	24179(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Angiotensin_II activates NF-kB through AT1A receptor recruitment of b-arrestin in cultured rat vascular smooth muscle cells .
27013094	0	NF-kB	61,66	BDNF	94,98	NF-kB	BDNF	309165(Tax:10116)	24225(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Venenum Bufonis induces rat neuroinflammation by activiating NF-kB pathway and attenuation of BDNF .
26073037	0	NF-kB	17,22	Cyclooxygenase-2	41,57	NF-kB	Cyclooxygenase-2	309165(Tax:10116)	29527(Tax:10116)	Gene	Gene	Translocation|nmod|START_ENTITY Translocation|nmod|END_ENTITY	Translocation of NF-kB and Expression of Cyclooxygenase-2 Are Enhanced by Ketamine-Induced Ulcerative_Cystitis in Rat Bladder .
22776966	0	NF-kB	32,37	Focal_adhesion_kinase	0,21	NF-kB	Focal adhesion kinase	81736(Tax:10116)	25614(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Focal_adhesion_kinase activates NF-kB via the ERK1/2 and p38MAPK Pathways in amyloid-b25-35-induced apoptosis in PC12 cells .
22001340	0	NF-kB	47,52	Gli1	99,103	NF-kB	Gli1	81736(Tax:10116)	140589(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Polydatin modulates inflammation by decreasing NF-kB activation and oxidative stress by increasing Gli1 , Ptch1 , SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain .
25000305	0	NF-kB	68,73	MMP-9	35,40	NF-kB	MMP-9	4790	4318	Gene	Gene	activation|amod|START_ENTITY blocking|dobj|activation suppresses|advcl|blocking suppresses|dobj|expression expression|compound|END_ENTITY	Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kB activation through MAPK signaling pathways in MCF-7 human breast_carcinoma cells .
26244598	0	NF-kB	17,22	MiR-210	0,7	NF-kB	MiR-210	81736(Tax:10116)	100314053(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	MiR-210 inhibits NF-kB signaling pathway by targeting DR6 in osteoarthritis .
26244598	0	NF-kB	17,22	MiR-210	0,7	NF-kB	MiR-210	81736(Tax:10116)	100314053(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	MiR-210 inhibits NF-kB signaling pathway by targeting DR6 in osteoarthritis .
25041941	0	NF-kB	56,61	NLRP3	63,68	NF-kB	NLRP3	81736(Tax:10116)	114548	Gene	Gene	production|amod|START_ENTITY production|dep|END_ENTITY	Vinpocetine inhibits amyloid-beta induced activation of NF-kB , NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells .
23496811	0	NF-kB	94,99	Nrf2	67,71	NF-kB	Nrf2	309165(Tax:10116)	83619(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY downregulates|nmod|activation downregulates|dobj|expression expression|nmod|END_ENTITY	Indoxyl_sulfate , a uremic toxin , downregulates renal expression of Nrf2 through activation of NF-kB .
23523906	0	NF-kB	87,92	TGF-b	103,108	NF-kB	TGF-b	81736(Tax:10116)	59086(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Berberine attenuates bleomycin induced pulmonary_toxicity and fibrosis via suppressing NF-kB dependant TGF-b activation : a biphasic experimental study .
26477714	0	NF-kB	110,115	TLR-2	82,87	NF-kB	TLR-2	309165(Tax:10116)	310553(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY induced|dobj|activation END_ENTITY|acl|induced	Candidaglabrata induced infection of rat tracheal epithelial cells is mediated by TLR-2 induced activation of NF-kB .
26667305	0	NF-kB	46,51	TNF-a	23,28	NF-kB	TNF-a	81736(Tax:10116)	24835(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Ashwagandha attenuates TNF-a - and LPS-induced NF-kB activation and CCL2 and CCL5 gene expression in NRK-52E cells .
21162919	0	NF-kB	14,19	iNOS	40,44	NF-kB	iNOS	81736(Tax:10116)	24599(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	-LSB- Dual role of NF-kB and its target gene iNOS in cerebral ischemic tolerance induced by focal ischemic preconditioning -RSB- .
23564451	0	NF-kB	156,161	nuclear_factor_kB	137,154	NF-kB	nuclear factor kB	81736(Tax:10116)	81736(Tax:10116)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- promotes both survival and neuritogenesis in PC12 cells through activation of nuclear_factor_kB -LRB- NF-kB -RRB- pathway : involvement of extracellular_signal-regulated_kinase -LRB- ERK -RRB- , calcium , and c-REL .
10908156	0	NF-kB	132,137	nuclear_transcription_factor_kB	99,130	NF-kB	nuclear transcription factor kB	309165(Tax:10116)	309165(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Interaction of the receptor for advanced glycation end products -LRB- RAGE -RRB- with transthyretin triggers nuclear_transcription_factor_kB -LRB- NF-kB -RRB- activation .
20735436	0	NF-kB-inducing_kinase	29,50	NIK	52,55	NF-kB-inducing kinase	NIK	9020	9020	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic alteration of the NF-kB-inducing_kinase -LRB- NIK -RRB- gene is involved in enhanced NIK expression in basal-like breast_cancer .
21217011	0	NF-kB1	0,6	ERK	84,87	NF-kB1	ERK	18033(Tax:10090)	26413(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|compound|END_ENTITY	NF-kB1 inhibits TLR-induced IFN-b production in macrophages through TPL-2-dependent ERK activation .
21217011	0	NF-kB1	0,6	IFN-b	28,33	NF-kB1	IFN-b	18033(Tax:10090)	15977(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	NF-kB1 inhibits TLR-induced IFN-b production in macrophages through TPL-2-dependent ERK activation .
25727407	0	NF-kB1	0,6	NF-kB2	8,14	NF-kB1	NF-kB2	18033(Tax:10090)	18034(Tax:10090)	Gene	Gene	regulate|advmod|START_ENTITY regulate|nsubj|END_ENTITY	NF-kB1 , NF-kB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice .
22575656	0	NF-kB1	99,105	microRNA-210	0,12	NF-kB1	microRNA-210	18033(Tax:10090)	387206(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-kB1 in murine macrophages .
25727407	0	NF-kB2	8,14	NF-kB1	0,6	NF-kB2	NF-kB1	18034(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|advmod|END_ENTITY	NF-kB1 , NF-kB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice .
24391649	0	NF-kB2	55,61	TRAF3	31,36	NF-kB2	TRAF3	4791	7187	Gene	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|END_ENTITY	A Complex Relationship between TRAF3 and Non-Canonical NF-kB2 Activation in B Lymphocytes .
23699654	0	NF-kB2	0,6	p52	7,10	NF-kB2	p52	4791	4791	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	NF-kB2 / p52 induces resistance to enzalutamide in prostate_cancer : role of androgen_receptor and its variants .
26646749	0	NF-kB_p50	82,91	Leucine-rich_repeat_kinase_2	0,28	NF-kB p50	Leucine-rich repeat kinase 2	4790	120892	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Leucine-rich_repeat_kinase_2 positively regulates inflammation and down-regulates NF-kB_p50 signaling in cultured microglia cells .
18081698	0	NF-kappaB	124,133	ABIN-3	38,44	NF-kappaB	ABIN-3	4790	79931	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF_and_toll-like_receptor_4 stimulation is itself regulated by NF-kappaB .
8932379	0	NF-kappaB	56,65	ACH-2	69,74	NF-kappaB	ACH-2	4790	641371	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Topoisomerase poisons activate the transcription factor NF-kappaB in ACH-2 and CEM cells .
17478723	0	NF-kappaB	14,23	ADAP	86,90	NF-kappaB	ADAP	18033(Tax:10090)	23880(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY Regulation|nmod|activation Regulation|nmod|END_ENTITY	Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1 .
10485711	0	NF-kappaB	0,9	AKT	25,28	NF-kappaB	AKT	4790	207	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling .
16427049	0	NF-kappaB	56,65	APOBEC2	14,21	NF-kappaB	APOBEC2	4790	10930	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of APOBEC2 is transcriptionally regulated by NF-kappaB in human hepatocytes .
19079347	0	NF-kappaB	26,35	ATM	0,3	NF-kappaB	ATM	4790	472	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic_syndrome and acute_myeloid_leukemia .
10982546	0	NF-kappaB	71,80	Adiponectin	0,11	NF-kappaB	Adiponectin	4790	9370	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Adiponectin , an adipocyte-derived plasma protein , inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway .
18537100	0	NF-kappaB	20,29	Adiponectin	0,11	NF-kappaB	Adiponectin	4790	9370	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	NF-kappaB	87,96	Adiponectin	0,11	NF-kappaB	Adiponectin	4790	9370	Gene	Gene	activation|amod|START_ENTITY suppression|nmod|activation leads|nmod|suppression activation|acl:relcl|leads induces|dobj|activation induces|nsubj|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
15527794	0	NF-kappaB	31,40	Adrenomedullin	0,14	NF-kappaB	Adrenomedullin	4790	133	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Adrenomedullin signals through NF-kappaB in epithelial cells .
12879015	0	NF-kappaB	16,25	Akt	55,58	NF-kappaB	Akt	4790	207	Gene	Gene	Inactivation|nmod|START_ENTITY mediated|nsubjpass|Inactivation mediated|nmod|END_ENTITY	Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast_cancer cells .
14580677	0	NF-kappaB	0,9	Akt	21,24	NF-kappaB	Akt	18033(Tax:10090)	11651(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	NF-kappaB stimulates Akt phosphorylation and gene expression by distinct signaling mechanisms .
16199483	0	NF-kappaB	29,38	Akt	81,84	NF-kappaB	Akt	18033(Tax:10090)	11651(Tax:10090)	Gene	Gene	ablation|amod|START_ENTITY afforded|nmod|ablation Cardioprotection|acl|afforded associated|nsubjpass|Cardioprotection associated|nmod|activation activation|nmod|END_ENTITY	Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha .
16450077	0	NF-kappaB	104,113	Akt	97,100	NF-kappaB	Akt	4790	207	Gene	Gene	signalling|nsubj|START_ENTITY operates|parataxis|signalling operates|nmod|_ _|compound|END_ENTITY	The antiatherogenic and antiinflammatory effect of HDL-associated lysosphingolipids operates via Akt _ -- > NF-kappaB signalling pathways in human vascular endothelial cells .
16543232	0	NF-kappaB	39,48	Akt	34,37	NF-kappaB	Akt	4790	207	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation and cross-talk between Akt , NF-kappaB , and unfolded protein response signaling in 1-LN prostate_cancer cells consequent to ligation of cell surface-associated GRP78 .
20619327	0	NF-kappaB	48,57	Akt	43,46	NF-kappaB	Akt	4790	207	Gene	Gene	START_ENTITY|nsubj|formation formation|appos|END_ENTITY	Hexavalent_chromium induced ROS formation , Akt , NF-kappaB , and MAPK activation , and TNF-alpha and IL-1alpha production in keratinocytes .
11108147	0	NF-kappaB	108,117	Angiotensin_II	0,14	NF-kappaB	Angiotensin II	4790	183	Gene	Gene	factor|appos|START_ENTITY effects|nmod|factor induces|nmod|effects induces|nsubj|END_ENTITY	Angiotensin_II induces gene transcription through cell-type-dependent effects on the nuclear_factor-kappaB -LRB- NF-kappaB -RRB- transcription factor .
15130920	0	NF-kappaB	121,130	Angiotensin_II	0,14	NF-kappaB	Angiotensin II	4790	183	Gene	Gene	activation|nmod|START_ENTITY adipocytes|nmod|activation stimulates|nmod|adipocytes stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB .
20215502	0	NF-kappaB	54,63	Annexin_1	0,9	NF-kappaB	Annexin 1	4790	301	Gene	Gene	induced|xcomp|START_ENTITY END_ENTITY|acl|induced	Annexin_1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation : anticancer effects in vitro and in vivo .
17935280	0	NF-kappaB	26,35	Aurora-A_kinase	0,15	NF-kappaB	Aurora-A kinase	4790	6790	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Aurora-A_kinase regulates NF-kappaB activity : lessons from combination studies .
20596645	0	NF-kappaB	95,104	BAD	76,79	NF-kappaB	BAD	4790	572	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	AF1q enhancement of gamma irradiation-induced apoptosis by up-regulation of BAD expression via NF-kappaB in human squamous_carcinoma A431 cells .
11519724	0	NF-kappaB	48,57	BCL-X	34,39	NF-kappaB	BCL-X	18033(Tax:10090)	24888(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain .
18349075	0	NF-kappaB	72,81	BCL10	31,36	NF-kappaB	BCL10	4790	8915	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	A20 is a negative regulator of BCL10 - and CARMA3-mediated activation of NF-kappaB .
19897484	0	NF-kappaB	47,56	BCL10	24,29	NF-kappaB	BCL10	4790	8915	Gene	Gene	production|amod|START_ENTITY required|nmod|production required|nsubjpass|lymphoma_10 lymphoma_10|appos|END_ENTITY	B-cell_CLL / lymphoma_10 -LRB- BCL10 -RRB- is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing_kinase -LRB- NIK -RRB- phosphorylation .
12759356	0	NF-kappaB	0,9	BMP-2	33,38	NF-kappaB	BMP-2	18033(Tax:10090)	12156(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro .
10021463	0	NF-kappaB	96,105	Bcl-2	0,5	NF-kappaB	Bcl-2	4790	596	Gene	Gene	inhibition|nmod|START_ENTITY serve|nmod|inhibition serve|nsubj|END_ENTITY	Bcl-2 and Bcl-XL serve an anti-inflammatory function in endothelial cells through inhibition of NF-kappaB .
10049353	0	NF-kappaB	77,86	Bcl-2	16,21	NF-kappaB	Bcl-2	4790	596	Gene	Gene	target|nmod|START_ENTITY Bfl-1|parataxis|target Bfl-1|amod|END_ENTITY	The prosurvival Bcl-2 homolog Bfl-1 / A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis .
10454539	0	NF-kappaB	0,9	Bcl-2	36,41	NF-kappaB	Bcl-2	4790	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl -1 to preferentially suppress chemotherapy-induced apoptosis .
10727020	0	NF-kappaB	112,121	Bcl-2	175,180	NF-kappaB	Bcl-2	18033(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
10727020	0	NF-kappaB	112,121	Bcl-2	58,63	NF-kappaB	Bcl-2	18033(Tax:10090)	12043(Tax:10090)	Gene	Gene	NF-kappaB|parataxis|START_ENTITY NF-kappaB|nmod|protein protein|compound|END_ENTITY	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
10727020	0	NF-kappaB	36,45	Bcl-2	175,180	NF-kappaB	Bcl-2	18033(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|NF-kappaB NF-kappaB|nmod|function function|nmod|END_ENTITY	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
10727020	0	NF-kappaB	36,45	Bcl-2	58,63	NF-kappaB	Bcl-2	18033(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Suppression of transcription factor NF-kappaB activity by Bcl-2 protein in NIH3T3 cells : implication of a novel NF-kappaB p50-Bcl-2 complex for the anti-apoptotic function of Bcl-2 .
12032828	0	NF-kappaB	0,9	Bcl-2	20,25	NF-kappaB	Bcl-2	4790	596	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	NF-kappaB activates Bcl-2 expression in t -LRB- 14 ; 18 -RRB- lymphoma cells .
15325238	0	NF-kappaB	59,68	Bcl-2	33,38	NF-kappaB	Bcl-2	4790	596	Gene	Gene	signaling|compound|START_ENTITY retrospective|nmod|signaling retrospective|nmod|mechanisms mechanisms|nmod|END_ENTITY	On the antioxidant mechanisms of Bcl-2 : a retrospective of NF-kappaB signaling and oxidative stress .
8698809	0	NF-kappaB	58,67	Bcl-2	0,5	NF-kappaB	Bcl-2	4790	596	Gene	Gene	activity|nmod|START_ENTITY down-regulates|dobj|activity down-regulates|nsubj|END_ENTITY	Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis .
18796561	0	NF-kappaB	52,61	Bcl-3	84,89	NF-kappaB	Bcl-3	4790	602	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Oxidative , multistep activation of the noncanonical NF-kappaB pathway via disulfide Bcl-3 / p50 complex .
10482545	0	NF-kappaB	83,92	Bcl-x	13,18	NF-kappaB	Bcl-x	18033(Tax:10090)	12048(Tax:10090)	Gene	Gene	type|dep|START_ENTITY expression|nmod|type expression|amod|END_ENTITY	Induction of Bcl-x -LRB- L -RRB- expression by human T-cell_leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax .
17540779	0	NF-kappaB	41,50	Bcl10	0,5	NF-kappaB	Bcl10	4790	8915	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells .
17540779	0	NF-kappaB	41,50	Bcl10	0,5	NF-kappaB	Bcl10	4790	8915	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells .
16508008	0	NF-kappaB	36,45	CARMA1	0,6	NF-kappaB	CARMA1	4790	84433	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	CARMA1 is required for Akt-mediated NF-kappaB activation in T cells .
19706536	0	NF-kappaB	50,59	CARMA1	19,25	NF-kappaB	CARMA1	4790	84433	Gene	Gene	activation|amod|START_ENTITY critical|nmod|activation critical|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells .
17434128	0	NF-kappaB	111,120	CBP	19,22	NF-kappaB	CBP	4790	1387	Gene	Gene	switching|nmod|START_ENTITY promotes|advcl|switching promotes|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
17434128	0	NF-kappaB	111,120	CBP	95,98	NF-kappaB	CBP	4790	1387	Gene	Gene	switching|nmod|START_ENTITY switching|dobj|preference preference|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
20947507	0	NF-kappaB	0,9	CD10	61,65	NF-kappaB	CD10	4790	4311	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155 / PU .1 pathway .
12846575	0	NF-kappaB	0,9	CD45	60,64	NF-kappaB	CD45	4790	5788	Gene	Gene	induction|amod|START_ENTITY requires|nsubj|induction requires|dobj|END_ENTITY	NF-kappaB induction by bisperoxovanadium compounds requires CD45 , p36 -LRB- LAT -RRB- , PKC , and IKK activity and exhibits kinetics of activation comparable to those of TCR/CD28 coengagement .
11062012	0	NF-kappaB	94,103	COX-2	22,27	NF-kappaB	COX-2	4790	4513	Gene	Gene	activation|nmod|START_ENTITY involve|dobj|activation involve|nsubj|induction induction|nmod|END_ENTITY	Ceramide induction of COX-2 and PGE -LRB- 2 -RRB- in pulmonary A549 cells does not involve activation of NF-kappaB .
12807725	0	NF-kappaB	68,77	COX-2	195,200	NF-kappaB	COX-2	4790	4513	Gene	Gene	activation|amod|START_ENTITY smoke-induced|dobj|activation cigarette|acl|smoke-induced cigarette|dep|correlation correlation|nmod|suppression suppression|nmod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
15067740	0	NF-kappaB	56,65	COX-2	84,89	NF-kappaB	COX-2	4790	5743	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid_arthritis synovial fibroblasts -RSB- .
15655349	0	NF-kappaB	95,104	COX-2	45,50	NF-kappaB	COX-2	4790	5743	Gene	Gene	nuclear_factor-kappa_B|appos|START_ENTITY expression|nmod|nuclear_factor-kappa_B expression|appos|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
16380122	0	NF-kappaB	119,128	COX-2	59,64	NF-kappaB	COX-2	4790	5743	Gene	Gene	upregulation|dep|START_ENTITY upregulation|nmod|END_ENTITY	Hirsutenone inhibits phorbol_ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells : NF-kappaB as a potential molecular target .
16474181	0	NF-kappaB	81,90	COX-2	57,62	NF-kappaB	COX-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Resveratrol inhibits phorbol_ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity .
18314621	0	NF-kappaB	1,10	COX-2	91,96	NF-kappaB	COX-2	4790	5743	Gene	Gene	expression|amod|START_ENTITY expression|dep|impact impact|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- NF-kappaB subunit p65/RelA expression in ovarian_carcinoma : prognostic impact and link to COX-2 overexpression -RSB- .
18761708	0	NF-kappaB	85,94	COX-2	20,25	NF-kappaB	COX-2	4790	5743	Gene	Gene	activity|nmod|START_ENTITY suppressing|dobj|activity expression|acl|suppressing expression|compound|END_ENTITY	Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia .
19393729	0	NF-kappaB	122,131	COX-2	63,68	NF-kappaB	COX-2	18033(Tax:10090)	17709(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY mediated|nmod|regulation END_ENTITY|acl:relcl|mediated	Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2 , TNF-alpha and iNOS expression , which is mediated by NF-kappaB regulation , in RAW264 .7 cells .
19494233	0	NF-kappaB	126,135	COX-2	29,34	NF-kappaB	COX-2	4790	5743	Gene	Gene	pathway|amod|START_ENTITY stimulate|nmod|pathway stimulate|dobj|expression expression|compound|END_ENTITY	Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced , calpain-dependent , NF-kappaB pathway .
19717552	0	NF-kappaB	91,100	COX-2	32,37	NF-kappaB	COX-2	4790	5743	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR , PDGFR/PI3K/Akt / NF-kappaB pathway and p300 in tracheal smooth muscle cells .
19885014	0	NF-kappaB	66,75	COX-2	26,31	NF-kappaB	COX-2	4790	4513	Gene	Gene	Activity|amod|START_ENTITY Suppression|nmod|Activity Down-regulate|nmod|Suppression Down-regulate|dobj|Expression Expression|compound|END_ENTITY	DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells .
9266823	0	NF-kappaB	28,37	COX-2	72,77	NF-kappaB	COX-2	4790	4513	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|control control|nmod|expression expression|compound|END_ENTITY	Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta .
19423687	0	NF-kappaB	85,94	CTGF	0,4	NF-kappaB	CTGF	18033(Tax:10090)	14219(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB .
18192506	0	NF-kappaB	86,95	Carma1	75,81	NF-kappaB	Carma1	18033(Tax:10090)	108723(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production .
15171702	0	NF-kappaB	43,52	Corticotropin-releasing_hormone	0,31	NF-kappaB	Corticotropin-releasing hormone	4790	1392	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Corticotropin-releasing_hormone stimulates NF-kappaB in human epidermal keratinocytes .
11932422	0	NF-kappaB	125,134	Cot	35,38	NF-kappaB	Cot	4790	1326	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	The oncogenic protein kinase Tpl-2 / Cot contributes to Epstein-Barr_virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2 .
12466023	0	NF-kappaB	46,55	Cyclooxygenase-2	0,16	NF-kappaB	Cyclooxygenase-2	4790	5743	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Cyclooxygenase-2 is a neuronal target gene of NF-kappaB .
11753679	0	NF-kappaB	118,127	DR6	54,57	NF-kappaB	DR6	4790	27242	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of DR6 , a member of the TNF receptor family , through activation of NF-kappaB .
18421578	0	NF-kappaB	71,80	Death_receptor-4	0,16	NF-kappaB	Death receptor-4	4790	8797	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Death_receptor-4 -LRB- DR4 -RRB- expression is regulated by transcription factor NF-kappaB in response to etoposide treatment .
16862183	0	NF-kappaB	0,9	E-cadherin	20,30	NF-kappaB	E-cadherin	4790	999	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	NF-kappaB represses E-cadherin expression and enhances epithelial_to_mesenchymal_transition of mammary epithelial cells : potential involvement of ZEB-1 and ZEB-2 .
10826501	0	NF-kappaB	86,95	Endothelin-1	0,12	NF-kappaB	Endothelin-1	4790	1906	Gene	Gene	activation|nmod|START_ENTITY release|nmod|activation induces|dobj|release induces|nsubj|END_ENTITY	Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-kappaB in human vascular smooth muscle cells .
16417466	0	NF-kappaB	90,99	Endothelin-1	0,12	NF-kappaB	Endothelin-1	4790	1906	Gene	Gene	induction|nmod|START_ENTITY promotes|dobj|induction promotes|nsubj|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma .
17460393	0	NF-kappaB	21,30	Endothelin-1	0,12	NF-kappaB	Endothelin-1	4790	1906	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Endothelin-1 induces NF-kappaB via two independent pathways in human renal tubular epithelial cells .
16375720	0	NF-kappaB	24,33	Erythropoietin	0,14	NF-kappaB	Erythropoietin	4790	2056	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal_injury during beta-amyloid toxicity .
15592525	0	NF-kappaB	107,116	FLASH	8,13	NF-kappaB	FLASH	4790	9994	Gene	Gene	mutant|nmod|START_ENTITY function|nmod|mutant Role|dep|function Role|nmod|END_ENTITY	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
15592525	0	NF-kappaB	107,116	FLASH	91,96	NF-kappaB	FLASH	4790	9994	Gene	Gene	mutant|nmod|START_ENTITY mutant|compound|END_ENTITY	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
15592525	0	NF-kappaB	50,59	FLASH	8,13	NF-kappaB	FLASH	4790	9994	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
15592525	0	NF-kappaB	50,59	FLASH	91,96	NF-kappaB	FLASH	4790	9994	Gene	Gene	activation|nmod|START_ENTITY FLASH|nmod|activation Role|nmod|FLASH Role|dep|function function|nmod|mutant mutant|compound|END_ENTITY	Role of FLASH in caspase-8-mediated activation of NF-kappaB : dominant-negative function of FLASH mutant in NF-kappaB signaling pathway .
19324905	0	NF-kappaB	123,132	FLICE	86,91	NF-kappaB	FLICE	4790	841	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Induction of CCL20 production by Kaposi_sarcoma-associated herpesvirus : role of viral FLICE inhibitory protein K13-induced NF-kappaB activation .
10229820	0	NF-kappaB	89,98	Fibroblast_growth_factor-1	0,26	NF-kappaB	Fibroblast growth factor-1	4790	2246	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- enhances IL-2 production and nuclear translocation of NF-kappaB in FGF_receptor-bearing Jurkat T cells .
15308101	0	NF-kappaB	14,23	Foxo3a	98,104	NF-kappaB	Foxo3a	18033(Tax:10090)	56484(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of NF-kappaB , Th activation , and autoinflammation by the forkhead transcription factor Foxo3a .
11429707	0	NF-kappaB	21,30	GADD45alpha	89,100	NF-kappaB	GADD45alpha	4790	1647	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Contrasting roles of NF-kappaB and JNK in arsenite-induced p53-independent expression of GADD45alpha .
15797874	0	NF-kappaB	0,9	GADD45beta	55,65	NF-kappaB	GADD45beta	18033(Tax:10090)	17873(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	NF-kappaB and not the MAPK signaling pathway regulates GADD45beta expression during acute inflammation .
12637324	0	NF-kappaB	16,25	GMCSF	0,5	NF-kappaB	GMCSF	4790	1437	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta .
18755269	0	NF-kappaB	34,43	GbetaL	0,6	NF-kappaB	GbetaL	4790	64223	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GbetaL regulates TNFalpha-induced NF-kappaB signaling by directly inhibiting the activation of IkappaB kinase .
17169985	0	NF-kappaB	45,54	Glucocorticoid-induced_leucine_zipper	0,37	NF-kappaB	Glucocorticoid-induced leucine zipper	4790	1831	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- / NF-kappaB interaction : role of GILZ homo-dimerization and C-terminal domain .
15240510	0	NF-kappaB	35,44	HIF-1	55,60	NF-kappaB	HIF-1	4790	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Hepatocyte_growth_factor-activated NF-kappaB regulates HIF-1 activity and ODC expression , implicated in survival , differently in different carcinoma cell lines .
19433587	0	NF-kappaB	17,26	HSCARG	0,6	NF-kappaB	HSCARG	4790	57407	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	HSCARG regulates NF-kappaB activation by promoting the ubiquitination of RelA or COMMD1 .
19331697	0	NF-kappaB	23,32	HSP27	14,19	NF-kappaB	HSP27	4790	3315	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Regulation of HSP27 on NF-kappaB pathway activation may be involved in metastatic hepatocellular_carcinoma cells apoptosis .
18950638	0	NF-kappaB	30,39	I-kappaBbeta	54,66	NF-kappaB	I-kappaBbeta	4790	4793	Gene	Gene	mechanism|nmod|START_ENTITY activation|nsubj|mechanism activation|nmod|END_ENTITY	A new regulatory mechanism of NF-kappaB activation by I-kappaBbeta in cancer cells .
10362102	0	NF-kappaB	103,112	ICAM-1	25,31	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	pathway|amod|START_ENTITY line|nmod|pathway induction|nmod|line induction|nmod|expression expression|compound|END_ENTITY	Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway .
10704144	0	NF-kappaB	92,101	ICAM-1	16,22	NF-kappaB	ICAM-1	18033(Tax:10090)	15894(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY involves|dobj|activation involves|nsubj|Upregulation Upregulation|nmod|expression expression|compound|END_ENTITY	Upregulation of ICAM-1 expression on J774 .2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase : comparison to induction of iNOS .
10891363	0	NF-kappaB	26,35	ICAM-1	72,78	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	START_ENTITY|nmod|transcription transcription|nmod|gene gene|compound|END_ENTITY	Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene .
12379212	0	NF-kappaB	39,48	ICAM-1	75,81	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	oligomer|nmod|START_ENTITY inhibits|nsubj|oligomer inhibits|dobj|expression expression|compound|END_ENTITY	A double-strand decoy DNA oligomer for NF-kappaB inhibits TNFalpha-induced ICAM-1 expression in sinusoidal endothelial cells .
17292586	0	NF-kappaB	14,23	ICAM-1	86,92	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	TNFR1-induced NF-kappaB , but not ERK , p38MAPK or JNK activation , mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells .
17334226	0	NF-kappaB	123,132	ICAM-1	71,77	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Extracellular HIV-1 Tat enhances monocyte adhesion by up-regulation of ICAM-1 and VCAM-1 gene expression via ROS-dependent NF-kappaB activation in astrocytes .
18241674	0	NF-kappaB	69,78	ICAM-1	18,24	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	activation|amod|START_ENTITY enhances|nmod|activation enhances|dobj|expression expression|amod|END_ENTITY	Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells .
19351910	0	NF-kappaB	0,9	ICAM-1	134,140	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|gene gene|amod|binding binding|nmod|site site|nmod|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
19351910	0	NF-kappaB	0,9	ICAM-1	37,43	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
19351910	0	NF-kappaB	112,121	ICAM-1	134,140	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
19351910	0	NF-kappaB	112,121	ICAM-1	37,43	NF-kappaB	ICAM-1	4790	3383	Gene	Gene	site|amod|START_ENTITY binding|nmod|site gene|amod|binding regulates|nmod|gene regulates|dobj|expression expression|compound|END_ENTITY	NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene .
20211170	0	NF-kappaB	120,129	ICAM-1	25,31	NF-kappaB	ICAM-1	18033(Tax:10090)	15894(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|dobj|expression expression|compound|END_ENTITY	Hydrogen_sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway .
20823682	0	NF-kappaB	117,126	ICAM-1	167,173	NF-kappaB	ICAM-1	18033(Tax:10090)	15894(Tax:10090)	Gene	Gene	recruitment|amod|START_ENTITY reducing|dobj|recruitment reducing|nmod|promoters promoters|compound|END_ENTITY	Amelioration of dextran sulfate_sodium-induced chronic_colitis by sulfasalazine_salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters .
19576240	0	NF-kappaB	68,77	IFNa1	44,49	NF-kappaB	IFNa1	4790	100137019(Tax:8030)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Atlantic_salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappaB and localizes to mitochondria .
17161612	0	NF-kappaB	12,21	IL-10	68,73	NF-kappaB	IL-10	18033(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|acl|mediating mediating|dobj|effects effects|nmod|END_ENTITY	The role of NF-kappaB in mediating the anti-inflammatory effects of IL-10 in intestinal epithelial cells .
10638662	0	NF-kappaB	22,31	IL-1beta	0,8	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	activation|amod|START_ENTITY induction|nmod|activation induction|amod|END_ENTITY	IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling .
11076795	0	NF-kappaB	84,93	IL-1beta	0,8	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	IL-1beta induces eotaxin gene transcription in A549 airway epithelial cells through NF-kappaB .
15820746	0	NF-kappaB	73,82	IL-1beta	0,8	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	argininosuccinate_synthetase|nmod|START_ENTITY argininosuccinate_synthetase|nsubj|stimulates stimulates|amod|END_ENTITY	IL-1beta stimulates argininosuccinate_synthetase gene expression through NF-kappaB in Caco-2 cells .
16112536	0	NF-kappaB	47,56	IL-1beta	23,31	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	activation|amod|START_ENTITY stimulation|nmod|activation stimulation|compound|END_ENTITY	Effect of myrrh oil on IL-1beta stimulation of NF-kappaB activation and PGE -LRB- 2 -RRB- production in human gingival fibroblasts and epithelial cells .
16617094	0	NF-kappaB	80,89	IL-1beta	48,56	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	kinases|compound|START_ENTITY role|nmod|kinases regulation|dep|role regulation|nmod|muscle muscle|nmod|END_ENTITY	GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha : role of NF-kappaB and MAP kinases .
16723203	0	NF-kappaB	137,146	IL-1beta	59,67	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	dependence|amod|START_ENTITY pointing|nmod|dependence pyrrolidine_dithiocarbamate|acl|pointing pyrrolidine_dithiocarbamate|amod|END_ENTITY	The NF-kappaB inhibitor pyrrolidine_dithiocarbamate blocks IL-1beta induced hyaluronan_synthase_1 -LRB- HAS1 -RRB- mRNA transcription , pointing at NF-kappaB dependence of the gene HAS1 .
16723203	0	NF-kappaB	4,13	IL-1beta	59,67	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	pyrrolidine_dithiocarbamate|amod|START_ENTITY pyrrolidine_dithiocarbamate|amod|END_ENTITY	The NF-kappaB inhibitor pyrrolidine_dithiocarbamate blocks IL-1beta induced hyaluronan_synthase_1 -LRB- HAS1 -RRB- mRNA transcription , pointing at NF-kappaB dependence of the gene HAS1 .
19481766	0	NF-kappaB	51,60	IL-1beta	20,28	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	translocation|amod|START_ENTITY END_ENTITY|nmod|translocation	Cyclic_AMP inhibits IL-1beta plus IFNgamma-induced NF-kappaB translocation in hepatocytes by a PKA independent mechanism .
19607899	1	NF-kappaB	86,95	IL-1beta	51,59	NF-kappaB	IL-1beta	18033(Tax:10090)	16176(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY blocking|dobj|activation inhibits|advcl|blocking inhibits|dobj|production production|nmod|END_ENTITY	inhibits the production of IL-1beta and IL-6 through blocking NF-kappaB , MAPK and Akt activation in macrophages .
19648113	0	NF-kappaB	156,165	IL-1beta	103,111	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|release release|appos|END_ENTITY	Injury-induced platelet-derived_growth_factor_receptor-alpha expression mediated by interleukin-1beta -LRB- IL-1beta -RRB- release and cooperative transactivation by NF-kappaB and ATF-4 : IL-1beta facilitates HDAC-1 / 2 dissociation from promoter .
19648113	0	NF-kappaB	156,165	IL-1beta	177,185	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	mediated|nmod|START_ENTITY mediated|parataxis|facilitates facilitates|compound|END_ENTITY	Injury-induced platelet-derived_growth_factor_receptor-alpha expression mediated by interleukin-1beta -LRB- IL-1beta -RRB- release and cooperative transactivation by NF-kappaB and ATF-4 : IL-1beta facilitates HDAC-1 / 2 dissociation from promoter .
19672968	0	NF-kappaB	76,85	IL-1beta	0,8	NF-kappaB	IL-1beta	18033(Tax:10090)	16176(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	IL-1beta enhances the antibacterial activity of astrocytes by activation of NF-kappaB .
19841186	0	NF-kappaB	67,76	IL-1beta	42,50	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	paradigm|amod|START_ENTITY Regulation|dep|paradigm Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of airway MUC5AC expression by IL-1beta and IL-17A ; the NF-kappaB paradigm .
20543863	0	NF-kappaB	48,57	IL-1beta	117,125	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|advcl|enhancing enhancing|dobj|expression expression|compound|END_ENTITY	L1CAM-integrin interaction induces constitutive NF-kappaB activation in pancreatic adenocarcinoma cells by enhancing IL-1beta expression .
8602829	0	NF-kappaB	105,114	IL-1beta	31,39	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	activity|compound|START_ENTITY associated|nmod|activity associated|nsubjpass|Inducibility Inducibility|nmod|mRNA mRNA|nmod|END_ENTITY	Inducibility of RANTES mRNA by IL-1beta in human bronchial epithelial cells is associated with increased NF-kappaB DNA binding activity .
9266823	0	NF-kappaB	28,37	IL-1beta	97,105	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|control control|nmod|expression expression|nmod|END_ENTITY	Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta .
9652398	0	NF-kappaB	87,96	IL-1beta	46,54	NF-kappaB	IL-1beta	4790	3553	Gene	Gene	nuclear_factor-kappaB|appos|START_ENTITY Effect|dep|nuclear_factor-kappaB Effect|nmod|dexamethasone dexamethasone|nmod|- -|appos|END_ENTITY	Effect of dexamethasone on interleukin-1beta - -LRB- IL-1beta -RRB- - induced nuclear_factor-kappaB -LRB- NF-kappaB -RRB- and kappaB-dependent transcription in epithelial cells .
10229820	0	NF-kappaB	89,98	IL-2	44,48	NF-kappaB	IL-2	4790	3558	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- enhances IL-2 production and nuclear translocation of NF-kappaB in FGF_receptor-bearing Jurkat T cells .
15322180	0	NF-kappaB	75,84	IL-2	18,22	NF-kappaB	IL-2	4790	3558	Gene	Gene	activation|amod|START_ENTITY preventing|dobj|activation inhibits|advcl|preventing inhibits|dobj|production production|compound|END_ENTITY	Ceramide inhibits IL-2 production by preventing protein_kinase_C-dependent NF-kappaB activation : possible role in protein_kinase_Ctheta regulation .
9584155	0	NF-kappaB	142,151	IL-2	118,122	NF-kappaB	IL-2	4790	3558	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|dobj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Mechanism responsible for T-cell antigen receptor - and CD28 - or interleukin_1 _ -LRB- IL-1 -RRB- receptor-initiated regulation of IL-2 gene expression by NF-kappaB .
15467434	0	NF-kappaB	0,9	IL-6	20,24	NF-kappaB	IL-6	4790	3569	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site , but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple_myeloma cells .
12164866	0	NF-kappaB	77,86	IL-8	114,118	NF-kappaB	IL-8	4790	3576	Gene	Gene	dependent|advmod|START_ENTITY up-regulation|amod|dependent up-regulation|nmod|END_ENTITY	Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-kappaB dependent up-regulation of IL-8 and MCP-1 .
12960242	0	NF-kappaB	120,129	IL-8	46,50	NF-kappaB	IL-8	4790	3576	Gene	Gene	activation|nmod|START_ENTITY generation|nmod|activation produce|nmod|generation produce|dobj|END_ENTITY	Nicotine induces human neutrophils to produce IL-8 through the generation of peroxynitrite and subsequent activation of NF-kappaB .
15280021	0	NF-kappaB	101,110	IL-8	52,56	NF-kappaB	IL-8	4790	3576	Gene	Gene	mechanism|nmod|START_ENTITY stimulates|nmod|mechanism stimulates|nmod|production production|nmod|END_ENTITY	Gliadin stimulates human monocytes to production of IL-8 and TNF-alpha through a mechanism involving NF-kappaB .
15521010	0	NF-kappaB	48,57	IL-8	74,78	NF-kappaB	IL-8	4790	3576	Gene	Gene	START_ENTITY|dobj|secretion secretion|compound|END_ENTITY	hPepT1 transports muramyl_dipeptide , activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells .
16076765	0	NF-kappaB	60,69	IL-8	36,40	NF-kappaB	IL-8	4790	3576	Gene	Gene	activation|amod|START_ENTITY induce|nmod|activation induce|dobj|production production|compound|END_ENTITY	Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells .
16128401	0	NF-kappaB	174,183	IL-8	50,54	NF-kappaB	IL-8	4790	3576	Gene	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|cytokines cytokines|amod|END_ENTITY	Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia_rickettsii_infection : regulation by nuclear transcription factor NF-kappaB .
16871430	0	NF-kappaB	59,68	IL-8	97,101	NF-kappaB	IL-8	4790	3576	Gene	Gene	activation|amod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic_adenocarcinoma cells .
17471497	0	NF-kappaB	98,107	IL-8	30,34	NF-kappaB	IL-8	4790	3576	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|regulation regulation|nmod|END_ENTITY	Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2 - and p38 kinase-dependent activation of AP-1 .
17581194	0	NF-kappaB	59,68	IL-8	27,31	NF-kappaB	IL-8	4790	3576	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB , but not RANTES , IL-6 , eotaxin or TARC expression in nasal epithelium .
18258920	0	NF-kappaB	46,55	IL-8	81,85	NF-kappaB	IL-8	4790	3576	Gene	Gene	inhibit|advmod|START_ENTITY inhibit|dobj|transcription transcription|nmod|END_ENTITY	Transcription factor oligodeoxynucleotides to NF-kappaB inhibit transcription of IL-8 in bronchial cells .
19837667	0	NF-kappaB	131,140	IL-8	37,41	NF-kappaB	IL-8	4790	3576	Gene	Gene	synergy|amod|START_ENTITY inhibits|nmod|synergy inhibits|dobj|production production|compound|END_ENTITY	Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate_cancer cells through suppressing EGR-1 / NF-kappaB synergy .
22043704	0	NF-kappaB	12,21	IL-8	43,47	NF-kappaB	IL-8	4790	3576	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of NF-kappaB on the expression of IL-8 in human bronchial epithelial cells induced by cigarette smoke condensates -RSB- .
22772035	0	NF-kappaB	116,125	IL-8	133,137	NF-kappaB	IL-8	4790	3576	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
22772035	0	NF-kappaB	116,125	IL-8	177,181	NF-kappaB	IL-8	4790	3576	Gene	Gene	promoter|amod|START_ENTITY recruitment|nmod|promoter recruitment|nmod|gene gene|compound|END_ENTITY	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
22772035	0	NF-kappaB	37,46	IL-8	133,137	NF-kappaB	IL-8	4790	3576	Gene	Gene	factors|amod|START_ENTITY targeting|dobj|factors molecules|acl|targeting Effects|nmod|molecules Effects|dep|recruitment recruitment|nmod|promoter promoter|amod|NF-kappaB NF-kappaB|nmod|gene gene|compound|END_ENTITY	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
22772035	0	NF-kappaB	37,46	IL-8	177,181	NF-kappaB	IL-8	4790	3576	Gene	Gene	factors|amod|START_ENTITY targeting|dobj|factors molecules|acl|targeting Effects|nmod|molecules Effects|dep|recruitment recruitment|nmod|gene gene|compound|END_ENTITY	Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic_fibrosis IB3-1 cells : recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene .
23156730	0	NF-kappaB	64,73	IL-8	30,34	NF-kappaB	IL-8	4790	3576	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- The effect of Hsp72 on IL-6 , IL-8 expression and activation of NF-kappaB in synoviocytes of rheumatoid_arthritis -RSB- .
9665590	0	NF-kappaB	60,69	IL-8	38,42	NF-kappaB	IL-8	4790	3576	Gene	Gene	activation|amod|START_ENTITY inhibition|nmod|activation down-regulates|nmod|inhibition down-regulates|dobj|END_ENTITY	IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation .
19576240	0	NF-kappaB	68,77	IPS-1	16,21	NF-kappaB	IPS-1	4790	57506	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Atlantic_salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappaB and localizes to mitochondria .
11254583	0	NF-kappaB	79,88	IRAK	53,57	NF-kappaB	IRAK	4790	3654	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
14673102	0	NF-kappaB	59,68	IRAK1	77,82	NF-kappaB	IRAK1	4790	3654	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 activation of NF-kappaB through IRAK1 and TRAF6 .
18395009	0	NF-kappaB	16,25	IRF-2	0,5	NF-kappaB	IRF-2	4790	3660	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB .
18809274	0	NF-kappaB	22,31	I_kappaB_alpha	65,79	NF-kappaB	I kappaB alpha	4790	4792	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Paeoniflorin suppress NF-kappaB activation through modulation of I_kappaB_alpha and enhances 5-fluorouracil-induced apoptosis in human gastric_carcinoma cells .
9346485	0	NF-kappaB	21,30	IkappaB_kinase-alpha	69,89	NF-kappaB	IkappaB kinase-alpha	4790	1147	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	IkappaB_kinase-beta : NF-kappaB activation and complex formation with IkappaB_kinase-alpha and NIK .
15212763	0	NF-kappaB	36,45	IkappaB_kinase_gamma	88,108	NF-kappaB	IkappaB kinase gamma	18033(Tax:10090)	16151(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	NF-kappaB inducing kinase activates NF-kappaB transcriptional activity independently of IkappaB_kinase_gamma through a p38_MAPK-dependent RelA phosphorylation pathway .
10340762	0	NF-kappaB	78,87	IkappaBalpha	8,20	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY Role|nmod|translocation Role|nmod|END_ENTITY	Role of IkappaBalpha and IkappaBbeta in the biphasic nuclear translocation of NF-kappaB in TNFalpha-stimulated astrocytes and in neuroblastoma cells .
10383397	1	NF-kappaB	120,129	IkappaBalpha	172,184	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY transcriptional|nsubj|Inhibition transcriptional|dobj|activity activity|nmod|degradation degradation|compound|END_ENTITY	Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation .
10400699	0	NF-kappaB	119,128	IkappaBalpha	66,78	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	inhibitor|nmod|START_ENTITY functions|nmod|inhibitor truncation|acl:relcl|functions truncation|nmod|END_ENTITY	Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB .
10454561	0	NF-kappaB	86,95	IkappaBalpha	123,135	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	START_ENTITY|acl:relcl|regulates regulates|dobj|promoter promoter|compound|END_ENTITY	Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter .
10962577	0	NF-kappaB	73,82	IkappaBalpha	98,110	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	cells|nmod|START_ENTITY sensitivity|nmod|cells enhanced|nsubjpass|sensitivity enhanced|nmod|END_ENTITY	Paclitaxel sensitivity of breast_cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide .
11416149	0	NF-kappaB	29,38	IkappaBalpha	101,113	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|xcomp|specific specific|nmod|END_ENTITY	Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha .
11416157	0	NF-kappaB	89,98	IkappaBalpha	43,55	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	mechanism|nmod|START_ENTITY provides|dobj|mechanism provides|nsubj|association association|nmod|END_ENTITY	Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes .
12444159	0	NF-kappaB	33,42	IkappaBalpha	116,128	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|compound|START_ENTITY inhibits|dobj|activation inhibits|nmod|suppression suppression|nmod|kinase kinase|compound|END_ENTITY	Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation .
12663663	0	NF-kappaB	89,98	IkappaBalpha	16,28	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	complexes|amod|START_ENTITY loop|nmod|complexes control|dep|loop control|nmod|phosphorylation phosphorylation|compound|END_ENTITY	RelA control of IkappaBalpha phosphorylation : a positive feedback loop for high affinity NF-kappaB complexes .
12807725	0	NF-kappaB	68,77	IkappaBalpha	111,123	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY smoke-induced|dobj|activation smoke-induced|nmod|inhibition inhibition|nmod|kinase kinase|compound|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells : correlation with suppression of COX-2 , MMP-9 and cyclin_D1 .
12909638	0	NF-kappaB	56,65	IkappaBalpha	98,110	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Hepatitis_C virus NS5A and subgenomic replicon activate NF-kappaB via tyrosine phosphorylation of IkappaBalpha and its degradation by calpain protease .
14630924	0	NF-kappaB	22,31	IkappaBalpha	120,132	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY activation|acl|induced induced|nmod|inhibition inhibition|nmod|kinase kinase|compound|END_ENTITY	Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation : abrogation of cyclin_D1 , cyclooxygenase-2 , and matrix metalloprotease-9 .
15372276	0	NF-kappaB	31,40	IkappaBalpha	124,136	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activity|amod|START_ENTITY activity|nmod|keratinocytes keratinocytes|nmod|increase increase|nmod|expression expression|compound|END_ENTITY	1alpha ,25 -LRB- OH -RRB- -LRB- 2 -RRB- D -LRB- 3 -RRB- regulates NF-kappaB DNA binding activity in cultured normal human keratinocytes through an increase in IkappaBalpha expression .
15731464	0	NF-kappaB	9,18	IkappaBalpha	68,80	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|stress stress|nmod|oscillations oscillations|compound|END_ENTITY	Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations : real-time analysis of flow-mediated activation in live cells .
15856023	0	NF-kappaB	15,24	IkappaBalpha	99,111	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha , IKK pathway in human prostate_cancer PC-3 cells .
16087206	0	NF-kappaB	124,133	IkappaBalpha	169,181	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY blockade|nmod|activation involves|dobj|blockade involves|nmod|increase increase|nmod|synthesis synthesis|compound|END_ENTITY	Inhibition of lipopolysaccharide-stimulated NO production by crotafuran_B in RAW 264.7 macrophages involves the blockade of NF-kappaB activation through the increase in IkappaBalpha synthesis .
16207380	0	NF-kappaB	52,61	IkappaBalpha	14,26	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY involves|dep|signaling involves|nsubj|Regulation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IkappaBalpha expression involves both NF-kappaB and the MAP kinase signaling pathways .
16231352	0	NF-kappaB	89,98	IkappaBalpha	110,122	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A high-fat diet impairs liver_regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor , IkappaBalpha .
16407234	0	NF-kappaB	30,39	IkappaBalpha	86,98	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	regulation|amod|START_ENTITY disrupts|dobj|regulation disrupts|advcl|blocking blocking|nmod|promoter promoter|compound|END_ENTITY	Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes .
16626517	0	NF-kappaB	82,91	IkappaBalpha	47,59	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	inhibitor|nmod|START_ENTITY Effects|appos|inhibitor Effects|nmod|transfer transfer|nmod|END_ENTITY	Effects of adenoviral gene transfer of mutated IkappaBalpha , a novel inhibitor of NF-kappaB , on human monocyte-derived dendritic cells .
17148610	0	NF-kappaB	64,73	IkappaBalpha	11,23	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	inhibition|nmod|START_ENTITY critical|nmod|inhibition END_ENTITY|acl:relcl|critical	Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB .
17310217	0	NF-kappaB	38,47	IkappaBalpha	0,12	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells .
17318178	0	NF-kappaB	13,22	IkappaBalpha	48,60	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	controls|dobj|START_ENTITY controls|nmod|deubiquitinylation deubiquitinylation|nmod|END_ENTITY	CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha .
17371256	0	NF-kappaB	15,24	IkappaBalpha	35,47	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	Control|nmod|START_ENTITY inhibitor|nsubj|Control inhibitor|dobj|END_ENTITY	Control of the NF-kappaB inhibitor IkappaBalpha in pathogen infection .
17441336	0	NF-kappaB	38,47	IkappaBalpha	22,34	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activity|amod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	-LSB- Regulatory effect of IkappaBalpha on NF-kappaB activity during viral gene transactivation in patients with steroid responsive simple nephrotic_syndrome -RSB- .
18224289	0	NF-kappaB	95,104	IkappaBalpha	16,28	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY tumor_necrosis_factor|dobj|activation inhibits|xcomp|tumor_necrosis_factor inhibits|nsubj|Modification Modification|nmod|END_ENTITY	Modification of IkappaBalpha by taurine_bromamine inhibits tumor_necrosis_factor alpha-induced NF-kappaB activation .
18353872	0	NF-kappaB	21,30	IkappaBalpha	81,93	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|compound|START_ENTITY occurs|nsubj|activation occurs|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells : involvement of Syk tyrosine kinase .
18401342	0	NF-kappaB	0,9	IkappaBalpha	46,58	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	dictates|nsubj|START_ENTITY dictates|dobj|pathway pathway|nmod|END_ENTITY	NF-kappaB dictates the degradation pathway of IkappaBalpha .
18511071	0	NF-kappaB	43,52	IkappaBalpha	12,24	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	signaling|compound|START_ENTITY control|nmod|signaling alters|dobj|control alters|nsubj|END_ENTITY	Pre-folding IkappaBalpha alters control of NF-kappaB signaling .
18606063	0	NF-kappaB	15,24	IkappaBalpha	33,45	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	transfection|compound|START_ENTITY transfection|compound|END_ENTITY	-LSB- Inhibition of NF-kappaB through IkappaBalpha transfection affects invasion of human lung_cancer cell line A549 -RSB- .
18632959	0	NF-kappaB	81,90	IkappaBalpha	63,75	NF-kappaB	IkappaBalpha	4790	406188(Tax:9823)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	The Npro product of classical_swine_fever_virus interacts with IkappaBalpha , the NF-kappaB inhibitor .
19327364	0	NF-kappaB	105,114	IkappaBalpha	130,142	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	DNA|compound|START_ENTITY DNA|amod|binding binding|nmod|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
19327364	0	NF-kappaB	105,114	IkappaBalpha	19,31	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	DNA|compound|START_ENTITY inhibition|nmod|DNA insights|nmod|inhibition Interaction|dep|insights Interaction|nmod|sequence sequence|compound|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
19327364	0	NF-kappaB	62,71	IkappaBalpha	130,142	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	sequence|nmod|START_ENTITY Interaction|nmod|sequence Interaction|dep|insights insights|nmod|inhibition inhibition|nmod|DNA DNA|amod|binding binding|nmod|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
19327364	0	NF-kappaB	62,71	IkappaBalpha	19,31	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	sequence|nmod|START_ENTITY sequence|compound|END_ENTITY	Interaction of the IkappaBalpha C-terminal PEST sequence with NF-kappaB : insights into the inhibition of NF-kappaB DNA binding by IkappaBalpha .
20378831	0	NF-kappaB	14,23	IkappaBalpha	63,75	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	responses|amod|START_ENTITY Regulation|nmod|responses Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of NF-kappaB responses by epigenetic suppression of IkappaBalpha expression in HCT116 intestinal epithelial cells .
20423347	0	NF-kappaB	127,136	IkappaBalpha	69,81	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY inhibiting|dobj|translocation inhibiting|nsubj|degradation degradation|compound|END_ENTITY	Shikonin reduces oedema induced by phorbol_ester by interfering with IkappaBalpha degradation thus inhibiting translocation of NF-kappaB to the nucleus .
20696914	0	NF-kappaB	33,42	IkappaBalpha	117,129	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY underlies|nsubj|regulation underlies|dobj|syndrome syndrome|nmod|mice mice|nmod|enhancers enhancers|nmod|promoter promoter|compound|END_ENTITY	Defective feedback regulation of NF-kappaB underlies Sjogren 's _ syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter .
21220295	0	NF-kappaB	118,127	IkappaBalpha	97,109	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	removes|dobj|START_ENTITY removes|nsubj|END_ENTITY	Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites .
21220295	0	NF-kappaB	34,43	IkappaBalpha	97,109	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	complex|nmod|START_ENTITY Detection|nmod|complex provides|nsubj|Detection provides|advcl|removes removes|nsubj|END_ENTITY	Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites .
8604224	0	NF-kappaB	14,23	IkappaBalpha	68,80	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	Inhibition|nmod|START_ENTITY activation|nsubj|Inhibition activation|nmod|mutant mutant|nmod|END_ENTITY	Inhibition of NF-kappaB activation by a dominant-negative mutant of IkappaBalpha .
9512545	0	NF-kappaB	116,125	IkappaBalpha	32,44	NF-kappaB	IkappaBalpha	4790	4792	Gene	Gene	transferred|nmod|START_ENTITY box|acl:relcl|transferred mediated|nmod|box mediated|nsubjpass|degradation degradation|nmod|END_ENTITY	Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB , bcl-3 or p53 .
9927206	0	NF-kappaB	47,56	IkappaBalpha	103,115	NF-kappaB	IkappaBalpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY blocks|dobj|activation blocks|nmod|phorbol_ester phorbol_ester|nmod|inhibition inhibition|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol_ester via inhibition of IkappaBalpha phosphorylation and degradation .
10224051	0	NF-kappaB	41,50	IkappaBbeta	8,19	NF-kappaB	IkappaBbeta	4790	4793	Gene	Gene	activation|amod|START_ENTITY maintains|dobj|activation maintains|nsubj|END_ENTITY	Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells .
11181838	0	NF-kappaB	0,9	IkappaBbeta	84,95	NF-kappaB	IkappaBbeta	4790	4793	Gene	Gene	involved|nsubjpass|START_ENTITY involved|parataxis|-LSB- -LSB-|nsubj|association association|nmod|END_ENTITY	NF-kappaB is involved in the survival of cerebellar granule neurons : association of IkappaBbeta -LSB- correction of Ikappabeta -RSB- phosphorylation with cell survival .
11571291	0	NF-kappaB	118,127	IkappaBbeta	0,11	NF-kappaB	IkappaBbeta	4790	4793	Gene	Gene	sequences|amod|START_ENTITY masking|dobj|sequences functions|advcl|masking functions|nsubj|END_ENTITY	IkappaBbeta , but not IkappaBalpha , functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells .
11571291	0	NF-kappaB	85,94	IkappaBbeta	0,11	NF-kappaB	IkappaBbeta	4790	4793	Gene	Gene	dimers|amod|START_ENTITY inhibitor|nmod|dimers functions|nmod|inhibitor functions|nsubj|END_ENTITY	IkappaBbeta , but not IkappaBalpha , functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells .
12672800	0	NF-kappaB	139,148	IkappaBbeta	125,136	NF-kappaB	IkappaBbeta	4790	4793	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes .
12686541	0	NF-kappaB	44,53	IkappaBbeta	30,41	NF-kappaB	IkappaBbeta	18033(Tax:10090)	18036(Tax:10090)	Gene	Gene	p65|compound|START_ENTITY p65|compound|END_ENTITY	X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex .
16792530	0	NF-kappaB	19,28	IkappaBbeta	36,47	NF-kappaB	IkappaBbeta	4790	4793	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	In vivo binding of NF-kappaB to the IkappaBbeta promoter is insufficient for transcriptional activation .
8628274	0	NF-kappaB	138,147	IkappaBbeta	16,27	NF-kappaB	IkappaBbeta	4790	4793	Gene	Gene	induction|nmod|START_ENTITY mechanism|nmod|induction Inactivation|dep|mechanism Inactivation|nmod|END_ENTITY	Inactivation of IkappaBbeta by the tax protein of human_T-cell_leukemia_virus_type_1 : a potential mechanism for constitutive induction of NF-kappaB .
16483929	0	NF-kappaB	0,9	JNK	37,40	NF-kappaB	JNK	18033(Tax:10090)	26419(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta .
12857898	0	NF-kappaB	68,77	Latent_membrane_protein_1	0,25	NF-kappaB	Latent membrane protein 1	4790	9260	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Latent_membrane_protein_1 of Epstein-Barr_virus induces CD83 by the NF-kappaB signaling pathway .
17445771	0	NF-kappaB	0,9	Lef1	20,24	NF-kappaB	Lef1	4790	51176	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	NF-kappaB regulates Lef1 gene expression in chondrocytes .
11429546	0	NF-kappaB	43,52	MEKK3	22,27	NF-kappaB	MEKK3	4790	4215	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	The essential role of MEKK3 in TNF-induced NF-kappaB activation .
16417466	0	NF-kappaB	90,99	MMP-2	29,34	NF-kappaB	MMP-2	4790	4313	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma .
19768635	0	NF-kappaB	92,101	MMP-2	31,36	NF-kappaB	MMP-2	4790	4313	Gene	Gene	activities|nmod|START_ENTITY reducing|dobj|activities inhibits|advcl|reducing inhibits|dobj|END_ENTITY	Plumbagin inhibits TPA-induced MMP-2 and u-PA expressions by reducing binding activities of NF-kappaB and AP-1 via ERK signaling pathway in A549 human lung_cancer cells .
20654108	0	NF-kappaB	88,97	MMP-2	22,27	NF-kappaB	MMP-2	4790	4313	Gene	Gene	-RSB-|amod|START_ENTITY activating|dobj|-RSB- upregulates|advcl|activating upregulates|dobj|expressions expressions|amod|END_ENTITY	-LSB- Visfatin upregulates MMP-2 and MMP-9 expressions in human monocytes through activating NF-kappaB -RSB- .
19275880	0	NF-kappaB	0,9	MMP-3	30,35	NF-kappaB	MMP-3	4790	4314	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	NF-kappaB and ZBP-89 regulate MMP-3 expression via a polymorphic site in the promoter .
17052690	0	NF-kappaB	70,79	MMP-9	37,42	NF-kappaB	MMP-9	4790	4318	Gene	Gene	activation|amod|START_ENTITY blocking|dobj|activation suppresses|advcl|blocking suppresses|dobj|expression expression|compound|END_ENTITY	Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human_aortic_smooth_muscle_cells .
18345028	0	NF-kappaB	76,85	MMP-9	39,44	NF-kappaB	MMP-9	4790	4318	Gene	Gene	activation|nmod|START_ENTITY inducing|nmod|activation inducing|dobj|activity activity|compound|END_ENTITY	Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1 .
20082219	0	NF-kappaB	66,75	MMP-9	95,100	NF-kappaB	MMP-9	4790	4318	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression .
20093109	0	NF-kappaB	31,40	MMP-9	44,49	NF-kappaB	MMP-9	4790	4318	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2 - -LRB- 4-bromophenyl -RRB- _ ethyl_caffeamide in human monocytic cells .
17196614	0	NF-kappaB	32,41	MYBBP1a	0,7	NF-kappaB	MYBBP1a	4790	10514	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	MYBBP1a is a novel repressor of NF-kappaB .
11254583	0	NF-kappaB	79,88	MyD88	45,50	NF-kappaB	MyD88	4790	4615	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
18070982	0	NF-kappaB	69,78	MyD88	29,34	NF-kappaB	MyD88	4790	4615	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	TRAF6 distinctively mediates MyD88 - and IRAK-1-induced activation of NF-kappaB .
17366569	0	NF-kappaB	77,86	NF-IL-6	41,48	NF-kappaB	NF-IL-6	4790	1051	Gene	Gene	IL-6|appos|START_ENTITY IL-6|appos|END_ENTITY	Activation of transcription factor IL-6 -LRB- NF-IL-6 -RRB- and nuclear factor-kappaB -LRB- NF-kappaB -RRB- by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells .
11698466	0	NF-kappaB	152,161	NF-kappaB	59,68	NF-kappaB	NF-kappaB	4790	4790	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	NF-kappaB-inducing_kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts .
11698466	0	NF-kappaB	59,68	NF-kappaB	152,161	NF-kappaB	NF-kappaB	4790	4790	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	NF-kappaB-inducing_kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts .
16723203	0	NF-kappaB	137,146	NF-kappaB	4,13	NF-kappaB	NF-kappaB	4790	4790	Gene	Gene	dependence|amod|START_ENTITY pointing|nmod|dependence pyrrolidine_dithiocarbamate|acl|pointing pyrrolidine_dithiocarbamate|amod|END_ENTITY	The NF-kappaB inhibitor pyrrolidine_dithiocarbamate blocks IL-1beta induced hyaluronan_synthase_1 -LRB- HAS1 -RRB- mRNA transcription , pointing at NF-kappaB dependence of the gene HAS1 .
16723203	0	NF-kappaB	4,13	NF-kappaB	137,146	NF-kappaB	NF-kappaB	4790	4790	Gene	Gene	pyrrolidine_dithiocarbamate|amod|START_ENTITY pyrrolidine_dithiocarbamate|acl|pointing pointing|nmod|dependence dependence|amod|END_ENTITY	The NF-kappaB inhibitor pyrrolidine_dithiocarbamate blocks IL-1beta induced hyaluronan_synthase_1 -LRB- HAS1 -RRB- mRNA transcription , pointing at NF-kappaB dependence of the gene HAS1 .
10648614	0	NF-kappaB	0,9	NF-kappaB-inducing_kinase	95,120	NF-kappaB	NF-kappaB-inducing kinase	4790	9020	Gene	Gene	activation|amod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|END_ENTITY	NF-kappaB activation by double-stranded-RNA-activated protein kinase -LRB- PKR -RRB- is mediated through NF-kappaB-inducing_kinase and IkappaB kinase .
11254583	0	NF-kappaB	79,88	NIK	67,70	NF-kappaB	NIK	4790	9020	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
20434986	0	NF-kappaB	31,40	NLRC5	0,5	NF-kappaB	NLRC5	4790	84166	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways .
18056399	0	NF-kappaB	27,36	NLRP2	0,5	NF-kappaB	NLRP2	4790	55655	Gene	Gene	pathway|amod|START_ENTITY inhibitor|nmod|pathway END_ENTITY|appos|inhibitor	NLRP2 , an inhibitor of the NF-kappaB pathway , is transcriptionally activated by NF-kappaB and exhibits a nonfunctional allelic variant .
18056399	0	NF-kappaB	80,89	NLRP2	0,5	NF-kappaB	NLRP2	4790	55655	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	NLRP2 , an inhibitor of the NF-kappaB pathway , is transcriptionally activated by NF-kappaB and exhibits a nonfunctional allelic variant .
18453612	0	NF-kappaB	89,98	NOX2	13,17	NF-kappaB	NOX2	4790	1536	Gene	Gene	activation|nmod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Dual role of NOX2 in respiratory_syncytial_virus - and sendai_virus-induced activation of NF-kappaB in airway epithelial cells .
10562553	0	NF-kappaB	117,126	NRF	59,62	NF-kappaB	NRF	4790	55922	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	Constitutive silencing of IFN-beta promoter is mediated by NRF -LRB- NF-kappaB-repressing_factor -RRB- , a nuclear inhibitor of NF-kappaB .
20702393	0	NF-kappaB	0,9	Nucling	38,45	NF-kappaB	Nucling	18033(Tax:10090)	72565(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	NF-kappaB regulates the expression of Nucling , a novel apoptosis regulator , with involvement of proteasome and caspase for its degradation .
9360945	0	NF-kappaB	21,30	Oct-2	51,56	NF-kappaB	Oct-2	4790	5452	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes .
11940383	0	NF-kappaB	10,19	PDGF-B	40,46	NF-kappaB	PDGF-B	4790	5155	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Effect of NF-kappaB on the induction of PDGF-B transcription by angiotensin_II in the ECV304 cell line .
14623898	0	NF-kappaB	103,112	PTEN	40,44	NF-kappaB	PTEN	4790	5728	Gene	Gene	nuclear_factor-kappaB|appos|START_ENTITY END_ENTITY|nmod|nuclear_factor-kappaB	Down-regulation of the tumor suppressor PTEN by the tumor_necrosis_factor-alpha / nuclear_factor-kappaB -LRB- NF-kappaB -RRB- - inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop .
19940030	0	NF-kappaB	46,55	PTEN	23,27	NF-kappaB	PTEN	4790	5728	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic_cancer cells .
18035491	0	NF-kappaB	63,72	Peptidoglycan_recognition_protein-S	0,35	NF-kappaB	Peptidoglycan recognition protein-S	18033(Tax:10090)	21946(Tax:10090)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Peptidoglycan_recognition_protein-S -LRB- PGRP-S -RRB- is upregulated by NF-kappaB .
19911008	0	NF-kappaB	15,24	Pim-1	0,5	NF-kappaB	Pim-1	4790	5292	Gene	Gene	START_ENTITY|nsubj|controls controls|amod|END_ENTITY	Pim-1 controls NF-kappaB signalling by stabilizing RelA/p65 .
19515451	0	NF-kappaB	49,58	Pin1	31,35	NF-kappaB	Pin1	18033(Tax:10090)	23988(Tax:10090)	Gene	Gene	binding|advmod|START_ENTITY facilitates|xcomp|binding facilitates|nsubj|isomerase isomerase|appos|END_ENTITY	The peptidyl-prolyl isomerase , Pin1 , facilitates NF-kappaB binding in hepatocytes and protects against hepatic_ischemia / reperfusion injury .
19668231	0	NF-kappaB	40,49	Pin1	21,25	NF-kappaB	Pin1	4790	5300	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma .
14518561	0	NF-kappaB	40,49	Platelet-type_12-lipoxygenase	0,29	NF-kappaB	Platelet-type 12-lipoxygenase	4790	239	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Platelet-type_12-lipoxygenase activates NF-kappaB in prostate_cancer cells .
15024053	0	NF-kappaB	85,94	Protein_kinase_Cdelta	0,21	NF-kappaB	Protein kinase Cdelta	4790	5580	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Protein_kinase_Cdelta selectively regulates protein_kinase_D-dependent activation of NF-kappaB in oxidative stress signaling .
15280372	0	NF-kappaB	61,70	Protein_kinase_Cdelta	0,21	NF-kappaB	Protein kinase Cdelta	4790	5580	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Protein_kinase_Cdelta mediates lysophosphatidic_acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells .
15467756	0	NF-kappaB	117,126	Pten	67,71	NF-kappaB	Pten	4790	5728	Gene	Gene	factors|amod|START_ENTITY factors|amod|due due|nmod|expression expression|amod|END_ENTITY	The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic_cancer cells .
20043910	0	NF-kappaB	14,23	RKIP	0,4	NF-kappaB	RKIP	4790	5037	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex .
12202396	0	NF-kappaB	47,56	RelB	83,87	NF-kappaB	RelB	18033(Tax:10090)	19698(Tax:10090)	Gene	Gene	switch|nmod|START_ENTITY switch|parataxis|inhibits inhibits|nsubj|expression expression|nmod|END_ENTITY	Regulation of Ig class switch recombination by NF-kappaB : retroviral expression of RelB in activated B cells inhibits switching to IgG1 , but not to IgE .
17446175	0	NF-kappaB	52,61	RelB	47,51	NF-kappaB	RelB	18033(Tax:10090)	19698(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis .
15178452	0	NF-kappaB	38,47	RhoA	0,4	NF-kappaB	RhoA	4790	387	Gene	Gene	activation|amod|START_ENTITY signals|nmod|activation signals|nsubj|END_ENTITY	RhoA and Rac1 signals in fMLP-induced NF-kappaB activation in human blood monocytes .
19602845	0	NF-kappaB	73,82	RhoA	64,68	NF-kappaB	RhoA	4790	387	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells .
17728102	0	NF-kappaB	30,39	RhoB	43,47	NF-kappaB	RhoB	4790	388	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	ROCK_I-mediated activation of NF-kappaB by RhoB .
19047046	5	NF-kappaB	907,916	SF	889,891	NF-kappaB	SF	18033(Tax:10090)	15234(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity stimulation|compound|END_ENTITY	Src enhanced basal and SF stimulated NF-kappaB activity and SF protection against ADR , in a manner dependent upon its kinase and Src homology 3 domains ; and endogenous Src was required for SF stimulation of NF-kappaB activity and cell protection .
12713738	0	NF-kappaB	29,38	SOCS	21,25	NF-kappaB	SOCS	18033(Tax:10090)	12700(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Regulatory effect of SOCS on NF-kappaB activity in murine monocytes/macrophages .
11176282	0	NF-kappaB	20,29	SOD1	0,4	NF-kappaB	SOD1	18033(Tax:10090)	20655(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	SOD1 down-regulates NF-kappaB and c-Myc expression in mice after transient focal cerebral_ischemia .
15724247	0	NF-kappaB	26,35	Serum_amyloid_A	0,15	NF-kappaB	Serum amyloid A	4790	6287	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Serum_amyloid_A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells .
16491128	0	NF-kappaB	28,37	Siva-1	0,6	NF-kappaB	Siva-1	4790	10572	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Siva-1 negatively regulates NF-kappaB activity : effect on T-cell receptor-mediated activation-induced cell death -LRB- AICD -RRB- .
19739098	0	NF-kappaB	44,53	Smac	12,16	NF-kappaB	Smac	4790	56616	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells .
18163503	0	NF-kappaB	45,54	Smad7	35,40	NF-kappaB	Smad7	4790	4092	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Interleukin-1beta up-regulation of Smad7 via NF-kappaB activation in human chondrocytes .
16288847	0	NF-kappaB	43,52	TGF-beta	56,64	NF-kappaB	TGF-beta	4790	7040	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon_cancer cells .
10388535	0	NF-kappaB	19,28	TGF-beta1	0,9	NF-kappaB	TGF-beta1	4790	7040	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits NF-kappaB activity through induction of IkappaB-alpha expression in human salivary gland cells : a possible mechanism of growth suppression by TGF-beta1 .
10388535	0	NF-kappaB	19,28	TGF-beta1	161,170	NF-kappaB	TGF-beta1	4790	7040	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|parataxis|mechanism mechanism|nmod|suppression suppression|nmod|END_ENTITY	TGF-beta1 inhibits NF-kappaB activity through induction of IkappaB-alpha expression in human salivary gland cells : a possible mechanism of growth suppression by TGF-beta1 .
12545162	0	NF-kappaB	24,33	TGF-beta1	71,80	NF-kappaB	TGF-beta1	18033(Tax:10090)	21803(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|AP-1 AP-1|compound|END_ENTITY	Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1 / SMAD signaling and apoptosis : implications in liver_tumor formation .
16565440	10	NF-kappaB	1730,1739	TGF-beta1	1700,1709	TGF-beta1	NF-kappaB	21803(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	In the RAW264 .7 line , SbG and baicalin stimulated TGF-beta1 gene expression via NF-kappaB and protein kinase C activation .
16690986	0	NF-kappaB	90,99	TGF-beta1	36,45	NF-kappaB	TGF-beta1	4790	7040	Gene	Gene	pathway|amod|START_ENTITY muscle|nmod|pathway induces|nmod|muscle induces|dobj|secretion secretion|compound|END_ENTITY	Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway .
18983820	0	NF-kappaB	23,32	TGF-beta1	118,127	NF-kappaB	TGF-beta1	4790	7040	Gene	Gene	Nuclear-factor-kappaB|appos|START_ENTITY play|nsubj|Nuclear-factor-kappaB play|nmod|END_ENTITY	Nuclear-factor-kappaB -LRB- NF-kappaB -RRB- and radical oxygen species play contrary roles in transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- - induced apoptosis_in_hepatocellular_carcinoma -LRB- HCC -RRB- cells .
15567069	0	NF-kappaB	70,79	TLR4	32,36	NF-kappaB	TLR4	4790	7099	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB .
10440583	0	NF-kappaB	52,61	TNF-alpha	34,43	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	The role of superoxide radical in TNF-alpha induced NF-kappaB activation .
11003979	0	NF-kappaB	0,9	TNF-alpha	47,56	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|loss loss|acl|induced induced|nmod|END_ENTITY	NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal_muscle_myotubes .
11045427	0	NF-kappaB	0,9	TNF-alpha	32,41	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	kinetics|amod|START_ENTITY predetermine|nsubj|kinetics predetermine|dobj|sensitivity sensitivity|amod|END_ENTITY	NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal_cancer cells .
12145100	0	NF-kappaB	148,157	TNF-alpha	0,9	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	pathways|compound|START_ENTITY requirement|nmod|pathways expression|dep|requirement potentiates|dobj|expression potentiates|nsubj|END_ENTITY	TNF-alpha , inefficient by itself , potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells : requirement of NF-kappaB and p38 MAPK pathways .
12213594	0	NF-kappaB	84,93	TNF-alpha	42,51	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	nuclear_factor-kappaB|dep|START_ENTITY translocation|amod|nuclear_factor-kappaB translocation|appos|END_ENTITY	Reduction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- related nuclear_factor-kappaB -LRB- NF-kappaB -RRB- translocation but not inhibitor kappa-B -LRB- Ikappa-B -RRB- - degradation by Rho protein inhibition in human endothelial cells .
12663241	0	NF-kappaB	94,103	TNF-alpha	133,142	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase expression|nmod|activation Tumor_necrosis_factor_alpha|dep|expression Tumor_necrosis_factor_alpha|dep|roles roles|nmod|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
12663241	0	NF-kappaB	94,103	TNF-alpha	29,38	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase expression|nmod|activation Tumor_necrosis_factor_alpha|dep|expression Tumor_necrosis_factor_alpha|appos|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
14646597	0	NF-kappaB	0,9	TNF-alpha	29,38	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|inhibition inhibition|amod|END_ENTITY	NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARgamma expression .
14963056	0	NF-kappaB	78,87	TNF-alpha	43,52	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY preventing|dobj|activation prevents|advcl|preventing prevents|dobj|expression expression|amod|END_ENTITY	Eicosapentaenoic_acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation .
15597152	0	NF-kappaB	0,9	TNF-alpha	119,128	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	translocation|amod|START_ENTITY potentiated|nsubjpass|translocation potentiated|nmod|signals signals|acl|co-secreted co-secreted|nmod|END_ENTITY	NF-kappaB translocation and endothelial cell activation is potentiated by macrophage-released signals co-secreted with TNF-alpha and IL-1beta .
15601669	0	NF-kappaB	103,112	TNF-alpha	76,85	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Characterization|dep|role Characterization|acl|signaling signaling|dobj|pathways pathways|acl|leading leading|xcomp|Fas Fas|dobj|expression expression|acl|induced induced|nmod|END_ENTITY	Characterization of signaling pathways leading to Fas expression induced by TNF-alpha : pivotal role of NF-kappaB .
15665513	0	NF-kappaB	43,52	TNF-alpha	0,9	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation .
15980040	0	NF-kappaB	114,123	TNF-alpha	51,60	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	phosphorylation|amod|START_ENTITY modulation|nmod|phosphorylation regulates|nmod|modulation regulates|dobj|production production|amod|END_ENTITY	Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation .
16000198	0	NF-kappaB	0,9	TNF-alpha	97,106	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	required|advmod|START_ENTITY required|nmod|protection protection|nmod|cytotoxicity cytotoxicity|amod|END_ENTITY	NF-kappaB activation but not PI3K/Akt is required for dexamethasone dependent protection against TNF-alpha cytotoxicity in L929 cells .
16075467	0	NF-kappaB	30,39	TNF-alpha	62,71	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	cytokines|amod|START_ENTITY feasibility|nmod|cytokines feasibility|dep|END_ENTITY	The feasibility of monitoring NF-kappaB associated cytokines : TNF-alpha , IL-1alpha , IL-6 , and IL-8 in whole saliva for the malignant_transformation_of_oral_lichen_planus .
16199483	0	NF-kappaB	29,38	TNF-alpha	108,117	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	ablation|amod|START_ENTITY afforded|nmod|ablation Cardioprotection|acl|afforded associated|nsubjpass|Cardioprotection associated|nmod|mice mice|acl|overexpressing overexpressing|dobj|END_ENTITY	Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha .
16428340	0	NF-kappaB	22,31	TNF-alpha	67,76	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	translocation|amod|START_ENTITY translocation|acl|activated activated|nmod|END_ENTITY	Rapamycin antagonizes NF-kappaB nuclear translocation activated by TNF-alpha in primary vascular smooth muscle cells and enhances apoptosis .
16584809	0	NF-kappaB	32,41	TNF-alpha	0,9	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	transport|nmod|START_ENTITY transport|amod|END_ENTITY	TNF-alpha mediated transport of NF-kappaB to the nucleus is independent of the cytoskeleton-based transport system in non-neuronal cells .
16595893	0	NF-kappaB	44,53	TNF-alpha	67,76	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	pitavastatin|nmod|START_ENTITY effect|nmod|pitavastatin activated|nsubj|effect activated|nmod|END_ENTITY	Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular_carcinoma cells .
16784892	0	NF-kappaB	59,68	TNF-alpha	19,28	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	loop|nmod|START_ENTITY loop|amod|END_ENTITY	Involvement of the TNF-alpha autocrine-paracrine loop , via NF-kappaB and YY1 , in the regulation of tumor cell resistance to Fas-induced apoptosis .
16879221	0	NF-kappaB	112,121	TNF-alpha	0,9	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	START_ENTITY|nsubj|suppression suppression|amod|END_ENTITY	TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB - and p38_MAPK-dependent .
17321745	0	NF-kappaB	123,132	TNF-alpha	27,36	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY blocking|dobj|activation cells|acl|blocking inhibits|nmod|cells inhibits|dobj|expression expression|amod|END_ENTITY	A_chromone analog inhibits TNF-alpha induced expression of cell adhesion molecules on human endothelial cells via blocking NF-kappaB activation .
17334236	0	NF-kappaB	31,40	TNF-alpha	0,9	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	PTEN|nmod|START_ENTITY upregulates|dobj|PTEN upregulates|nsubj|END_ENTITY	TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells .
17339489	0	NF-kappaB	24,33	TNF-alpha	97,106	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY study|nmod|activation study|dep|relevance relevance|nmod|END_ENTITY	A quantitative study of NF-kappaB activation by H2O2 : relevance in inflammation and synergy with TNF-alpha .
17374495	0	NF-kappaB	14,23	TNF-alpha	102,111	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY Regulation|nmod|activation nitric_oxide|nsubj|Regulation nitric_oxide|nmod|cells cells|amod|END_ENTITY	Regulation of NF-kappaB activation and nuclear translocation by exogenous nitric_oxide -LRB- NO -RRB- donors in TNF-alpha activated vascular endothelial cells .
17481363	0	NF-kappaB	29,38	TNF-alpha	93,102	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	translocation|amod|START_ENTITY Analysis|nmod|translocation Analysis|nmod|cells cells|appos|END_ENTITY	Analysis and quantitation of NF-kappaB nuclear translocation in tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- activated vascular endothelial cells .
17764673	0	NF-kappaB	108,117	TNF-alpha	18,27	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	suppression|nmod|START_ENTITY endothelial|nmod|suppression neutrophils|xcomp|endothelial activation|amod|neutrophils adhesion|nmod|activation adhesion|amod|END_ENTITY	Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation .
17879952	0	NF-kappaB	50,59	TNF-alpha	106,115	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY induced|dobj|activation induced|nmod|END_ENTITY	Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha .
17879952	0	NF-kappaB	50,59	TNF-alpha	32,41	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY induced|dobj|activation END_ENTITY|acl|induced	Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha .
18537078	0	NF-kappaB	122,131	TNF-alpha	53,62	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY macrophages|nmod|suppression inhibits|nmod|macrophages inhibits|dobj|production production|amod|END_ENTITY	Hinokitiol , a natural tropolone derivative , inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB .
18550789	0	NF-kappaB	108,117	TNF-alpha	14,23	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	pathway|amod|START_ENTITY death|nmod|pathway signaling|dobj|death mediates|dep|signaling mediates|nsubj|END_ENTITY	Transmembrane TNF-alpha mediates `` forward '' and `` reverse '' signaling , inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt_lymphoma cells .
19038972	0	NF-kappaB	48,57	TNF-alpha	0,9	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	MAPK|amod|START_ENTITY reduces|nmod|MAPK reduces|nsubj|END_ENTITY	TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model .
19113817	0	NF-kappaB	56,65	TNF-alpha	69,78	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	induction|nmod|START_ENTITY facilitates|dobj|induction facilitates|nmod|END_ENTITY	Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha .
19393729	0	NF-kappaB	122,131	TNF-alpha	70,79	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY mediated|nmod|regulation COX-2|acl:relcl|mediated COX-2|appos|expression expression|amod|END_ENTITY	Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2 , TNF-alpha and iNOS expression , which is mediated by NF-kappaB regulation , in RAW264 .7 cells .
19602845	0	NF-kappaB	73,82	TNF-alpha	29,38	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY RhoA|nmod|activation upregulation|nmod|RhoA induces|dobj|upregulation induces|nsubj|Tumor_necrosis_factor-alpha Tumor_necrosis_factor-alpha|appos|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells .
19995599	0	NF-kappaB	63,72	TNF-alpha	35,44	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	acts|nmod|START_ENTITY acts|nmod|inhibitor inhibitor|amod|END_ENTITY	Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB .
20372995	0	NF-kappaB	176,185	TNF-alpha	144,153	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	example|nmod|START_ENTITY example|acl|protecting protecting|dobj|lymphocytes lymphocytes|nmod|activation activation|amod|END_ENTITY	Critical need for clinical trials : an example of a pilot human intervention trial of a mixture of natural agents protecting lymphocytes against TNF-alpha induced activation of NF-kappaB .
20567236	0	NF-kappaB	123,132	TNF-alpha	60,69	NF-kappaB	TNF-alpha	4790	7124	Gene	Gene	suppression|nmod|START_ENTITY Selective|nmod|suppression Selective|dobj|deletion deletion|nmod|adipocytes adipocytes|nmod|END_ENTITY	Selective deletion of adipocytes , but not preadipocytes , by TNF-alpha through C/EBP - and PPARgamma-mediated suppression of NF-kappaB .
21196314	0	NF-kappaB	19,28	TNF-alpha	0,9	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	TNF-alpha mediated NF-kappaB activation is constantly extended by transglutaminase_2 .
23578838	0	NF-kappaB	16,25	TNF-alpha	60,69	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	astrocytes|nsubj|START_ENTITY astrocytes|dobj|expression expression|amod|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
23947625	0	NF-kappaB	16,25	TNF-alpha	60,69	NF-kappaB	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	astrocytes|nsubj|START_ENTITY astrocytes|dobj|expression expression|amod|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
10486238	0	NF-kappaB	29,38	TNFalpha	59,67	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Role of transcription factor NF-kappaB in asbestos-induced TNFalpha response from macrophages .
10644980	0	NF-kappaB	47,56	TNFalpha	29,37	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	activity|amod|START_ENTITY requires|dobj|activity requires|nsubj|Induction Induction|nmod|p21Waf1/Cip1 p21Waf1/Cip1|nmod|END_ENTITY	Induction of p21Waf1/Cip1 by TNFalpha requires NF-kappaB activity and antagonizes apoptosis in Ewing_tumor cells .
11238728	0	NF-kappaB	62,71	TNFalpha	129,137	NF-kappaB	TNFalpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	p52|compound|START_ENTITY converts|nsubj|p52 converts|dobj|effects effects|nmod|END_ENTITY	Inhibition of tumour necrosis factor-alpha -LRB- TNFalpha -RRB- - induced NF-kappaB p52 converts the metabolic effects of microglial-derived TNFalpha on mouse cerebellar neurones to neurotoxicity .
11238728	0	NF-kappaB	62,71	TNFalpha	44,52	NF-kappaB	TNFalpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	p52|compound|START_ENTITY converts|nsubj|p52 necrosis|parataxis|converts necrosis|dobj|factor-alpha factor-alpha|appos|END_ENTITY	Inhibition of tumour necrosis factor-alpha -LRB- TNFalpha -RRB- - induced NF-kappaB p52 converts the metabolic effects of microglial-derived TNFalpha on mouse cerebellar neurones to neurotoxicity .
11831701	0	NF-kappaB	118,127	TNFalpha	80,88	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	induction|nmod|START_ENTITY mediated|nmod|induction mediated|nsubjpass|Stimulation Stimulation|nmod|enhancer/promoter enhancer/promoter|nmod|cells cells|nmod|END_ENTITY	Stimulation of the human_cytomegalovirus IE enhancer/promoter in HL-60 cells by TNFalpha is mediated via induction of NF-kappaB .
12859994	0	NF-kappaB	163,172	TNFalpha	11,19	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	role|nmod|START_ENTITY progenitors|nmod|role progenitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of TNFalpha on the growth and sensitivity to cytosine_arabinoside of blast progenitors in acute_myelogenous_leukemia with special reference to the role of NF-kappaB .
15036249	0	NF-kappaB	44,53	TNFalpha	17,25	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Aspirin inhibits TNFalpha - and IL-1-induced NF-kappaB activation and sensitizes HeLa cells to apoptosis .
15380520	0	NF-kappaB	14,23	TNFalpha	96,104	NF-kappaB	TNFalpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY converts|nsubj|Inhibition converts|parataxis|mediated mediated|nmod|END_ENTITY	Inhibition of NF-kappaB in cancer cells converts inflammation - induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression .
16492740	0	NF-kappaB	31,40	TNFalpha	0,8	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells .
16933209	0	NF-kappaB	112,121	TNFalpha	37,45	NF-kappaB	TNFalpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY response|dep|role response|nmod|/ /|compound|END_ENTITY	Differential teratogenic response of TNFalpha + / + and TNFalpha - / - mice to cyclophosphamide : the possible role of NF-kappaB .
17925009	0	NF-kappaB	34,43	TNFalpha	7,15	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY trimers|dobj|activation trimers|nsubj|END_ENTITY	Single TNFalpha trimers mediating NF-kappaB activation : stochastic robustness of NF-kappaB signaling .
17925009	0	NF-kappaB	81,90	TNFalpha	7,15	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	signaling|compound|START_ENTITY robustness|nmod|signaling activation|dep|robustness trimers|dobj|activation trimers|nsubj|END_ENTITY	Single TNFalpha trimers mediating NF-kappaB activation : stochastic robustness of NF-kappaB signaling .
19414075	0	NF-kappaB	95,104	TNFalpha	0,8	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	triggering|dobj|START_ENTITY promotes|advcl|triggering promotes|nsubj|END_ENTITY	TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway .
19459480	0	NF-kappaB	30,39	TNFalpha	41,49	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	-RSB-|advmod|START_ENTITY -RSB-|nsubj|genes genes|compound|END_ENTITY	-LSB- Study of expression of TLR9 , NF-kappaB , TNFalpha genes in cells of cervical canal mucosa in pregnant women with herpesvirus_infection -RSB- .
20663918	0	NF-kappaB	75,84	TNFalpha	24,32	NF-kappaB	TNFalpha	4790	7124	Gene	Gene	responses|amod|START_ENTITY dynamics|nmod|responses induce|dobj|dynamics induce|nsubj|levels levels|nmod|stimulation stimulation|compound|END_ENTITY	Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells .
8612692	0	NF-kappaB	61,70	TNFalpha	24,32	NF-kappaB	TNFalpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	translocation|amod|START_ENTITY activation|nmod|translocation mechanisms|dep|activation mechanisms|nmod|cytotoxicity cytotoxicity|compound|END_ENTITY	Molecular mechanisms of TNFalpha cytotoxicity : activation of NF-kappaB and nuclear translocation .
16959613	0	NF-kappaB	60,69	TSC1	43,47	NF-kappaB	TSC1	4790	7248	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Essential role of tuberous_sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival .
17041011	0	NF-kappaB	112,121	Tachykinin-1_receptor	0,21	NF-kappaB	Tachykinin-1 receptor	4790	6869	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Tachykinin-1_receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-kappaB via a G -LRB- q -RRB- - dependent pathway .
10482545	0	NF-kappaB	83,92	Tax	142,145	NF-kappaB	Tax	18033(Tax:10090)	1491938(Tax:11908)	Gene	Gene	type|dep|START_ENTITY expression|nmod|type Induction|nmod|expression transfectants|nsubj|Induction transfectants|nmod|END_ENTITY	Induction of Bcl-x -LRB- L -RRB- expression by human T-cell_leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax .
11027516	0	NF-kappaB	62,71	Tax	50,53	NF-kappaB	Tax	4790	1491938(Tax:11908)	Gene	Gene	pathway|amod|START_ENTITY promoter|nmod|pathway promoter|nmod|END_ENTITY	Transactivation of fibronectin promoter by HTLV-I Tax through NF-kappaB pathway .
17942533	0	NF-kappaB	107,116	Tax	39,42	NF-kappaB	Tax	4790	6900	Gene	Gene	activation|amod|START_ENTITY Ubc13|nmod|activation requires|dobj|Ubc13 requires|nsubj|oncoprotein oncoprotein|compound|END_ENTITY	The human T-cell_leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation .
18425496	0	NF-kappaB	19,28	Tax	140,143	NF-kappaB	Tax	4790	6900	Gene	Gene	activation|amod|START_ENTITY enhanced|nsubjpass|activation HTLV-1|acl:relcl|enhanced HTLV-1|dep|mechanism mechanism|nmod|oncogenicity oncogenicity|compound|END_ENTITY	HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate : mechanism and implications for Tax oncogenicity .
18504428	0	NF-kappaB	51,60	Tax	118,121	NF-kappaB	Tax	4790	1491938(Tax:11908)	Gene	Gene	genes|nmod|START_ENTITY Activation|nmod|genes critical|nsubj|Activation critical|nmod|progression progression|acl|induced induced|nmod|END_ENTITY	Activation of the cyclin_D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax .
19129196	0	NF-kappaB	124,133	Tax	7,10	NF-kappaB	Tax	4790	6900	Gene	Gene	activation|nmod|START_ENTITY microdomains|nmod|activation hijacks|nmod|microdomains modulator|acl:relcl|hijacks modulator|nsubj|END_ENTITY	HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB .
9658126	0	NF-kappaB	67,76	Tax	56,59	NF-kappaB	Tax	4790	1491938(Tax:11908)	Gene	Gene	activation|amod|START_ENTITY induce|dobj|activation induce|nsubj|forms forms|nmod|END_ENTITY	Cytoplasmic forms of human_T-cell_leukemia_virus_type_1 Tax induce NF-kappaB activation .
9710600	0	NF-kappaB	52,61	Tax	35,38	NF-kappaB	Tax	4790	6900	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Human_T-cell_leukemia_virus_type_1 Tax induction of NF-kappaB involves activation of the IkappaB_kinase_alpha -LRB- IKKalpha -RRB- and IKKbeta cellular kinases .
9692893	0	NF-kappaB	0,9	Th2	13,16	NF-kappaB	Th2	18033(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	NF-kappaB in Th2 cells : delayed and long-lasting induction through the TCR complex .
15894821	0	NF-kappaB	29,38	Toll-like_receptor_4	8,28	NF-kappaB	Toll-like receptor 4	4790	7099	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|Role Role|dep|END_ENTITY	Role of Toll-like_receptor_4 / NF-kappaB pathway in monocyte-endothelial adhesion induced by low shear stress and ox-LDL .
17082484	0	NF-kappaB	33,42	Toll-like_receptor_4	12,32	NF-kappaB	Toll-like receptor 4	18033(Tax:10090)	21898(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY Role|dep|pathway Role|nmod|END_ENTITY	Role of the Toll-like_receptor_4 / NF-kappaB pathway in saturated_fatty_acid-induced inflammatory changes in the interaction between adipocytes and macrophages .
11753679	0	NF-kappaB	118,127	Tumor_necrosis_factor-alpha	0,27	NF-kappaB	Tumor necrosis factor-alpha	4790	7124	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of DR6 , a member of the TNF receptor family , through activation of NF-kappaB .
11450703	0	NF-kappaB	141,150	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	Tumor necrosis factor alpha	4790	7124	Gene	Gene	cells|nmod|START_ENTITY HCS-2|dep|cells induces|nmod|HCS-2 induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2 / 8 cells through activation of NF-kappaB : abrogation of the tumor_necrosis_factor_alpha effect by proteasome inhibitors .
12663241	0	NF-kappaB	94,103	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	Tumor necrosis factor alpha	4790	7124	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase expression|nmod|activation END_ENTITY|dep|expression	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
15485901	0	NF-kappaB	41,50	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	Tumor necrosis factor alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Tumor_necrosis_factor_alpha induction of NF-kappaB requires the novel coactivator SIMPL .
19854828	0	NF-kappaB	152,161	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	Tumor necrosis factor alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY interfering|nmod|activation signaling|advcl|interfering protein|acl|signaling represses|dobj|protein represses|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha represses bone morphogenetic protein -LRB- BMP -RRB- signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB .
8939978	0	NF-kappaB	85,94	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	Tumor necrosis factor alpha	4790	7124	Gene	Gene	activation|nmod|START_ENTITY early|nmod|activation induces|advmod|early induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces the adenovirus early 3 promoter by activation of NF-kappaB .
9099747	0	NF-kappaB	38,47	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	Tumor necrosis factor alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	fibroblasts|amod|START_ENTITY activates|dobj|fibroblasts activates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha activates NF-kappaB in acid_sphingomyelinase-deficient mouse embryonic fibroblasts .
18280249	0	NF-kappaB	59,68	URP2SF	0,6	NF-kappaB	URP2SF	4790	83706	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	URP2SF , a FERM and PH domain containing protein , regulates NF-kappaB and apoptosis .
17942533	0	NF-kappaB	107,116	Ubc13	97,102	NF-kappaB	Ubc13	4790	7334	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	The human T-cell_leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation .
11735124	0	NF-kappaB	0,9	VCAM-1	52,58	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells .
11821020	0	NF-kappaB	85,94	VCAM-1	113,119	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells .
15998244	0	NF-kappaB	0,9	VCAM-1	55,61	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	interplay|nsubj|START_ENTITY interplay|nmod|expression expression|compound|END_ENTITY	NF-kappaB , Nrf2 , and HO-1 interplay in redox-regulated VCAM-1 expression .
16288471	0	NF-kappaB	140,149	VCAM-1	30,36	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	p300|dep|START_ENTITY involvement|nmod|p300 regulation|dep|involvement regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of VCAM-1 expression by tumor_necrosis_factor-alpha in human tracheal smooth muscle cells : involvement of MAPKs , NF-kappaB , p300 , and histone acetylation .
16480622	0	NF-kappaB	116,125	VCAM-1	88,94	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	-RSB-|compound|START_ENTITY induced|nmod|-RSB- Activation|acl|induced Activation|nmod|END_ENTITY	-LSB- Activation of p38 MAPK signal transduction pathway by burn serum and the expression of VCAM-1 in HUVECs induced by NF-kappaB -RSB- .
17993261	0	NF-kappaB	29,38	VCAM-1	57,63	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	translocation|nmod|START_ENTITY sufficient|nsubj|translocation sufficient|nmod|expression expression|amod|END_ENTITY	Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1 , but not ICAM-1 , expression in TNF-stimulated smooth muscle cells : Differential requirement for PARP-1 expression and interaction .
19617655	0	NF-kappaB	107,116	VCAM-1	40,46	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	activation|appos|START_ENTITY inhibiting|dobj|activation reduces|advcl|inhibiting reduces|dobj|END_ENTITY	Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activation .
20966071	0	NF-kappaB	23,32	VCAM-1	108,114	NF-kappaB	VCAM-1	4790	7412	Gene	Gene	Phosphorylation|nmod|START_ENTITY critical|nsubj|Phosphorylation critical|nmod|expression expression|compound|END_ENTITY	Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent_protein_kinase is critical for VCAM-1 expression upon TNF treatment .
19901262	0	NF-kappaB	84,93	VEGFR-3	64,71	NF-kappaB	VEGFR-3	4790	2324	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1 .
19520742	0	NF-kappaB	134,143	Vascular_cell_adhesion_molecule-1	0,33	NF-kappaB	Vascular cell adhesion molecule-1	4790	7412	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Vascular_cell_adhesion_molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK / NF-kappaB : inhibitory role of curcumin .
18029035	0	NF-kappaB	38,47	Ymer	15,19	NF-kappaB	Ymer	4790	152137	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain .
18537100	0	NF-kappaB	20,29	adiponectin	148,159	NF-kappaB	adiponectin	4790	9370	Gene	Gene	activation|amod|START_ENTITY activation|acl:relcl|leads leads|dobj|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	NF-kappaB	20,29	adiponectin	186,197	NF-kappaB	adiponectin	4790	9370	Gene	Gene	activation|amod|START_ENTITY activation|acl:relcl|leads leads|dobj|adiponectin adiponectin|nmod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	NF-kappaB	87,96	adiponectin	148,159	NF-kappaB	adiponectin	4790	9370	Gene	Gene	activation|amod|START_ENTITY suppression|nmod|activation leads|nmod|suppression leads|dobj|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	NF-kappaB	87,96	adiponectin	186,197	NF-kappaB	adiponectin	4790	9370	Gene	Gene	activation|amod|START_ENTITY suppression|nmod|activation leads|nmod|suppression leads|dobj|adiponectin adiponectin|nmod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
11940383	0	NF-kappaB	10,19	angiotensin_II	64,78	NF-kappaB	angiotensin II	4790	183	Gene	Gene	Effect|nmod|START_ENTITY transcription|nsubj|Effect transcription|nmod|END_ENTITY	Effect of NF-kappaB on the induction of PDGF-B transcription by angiotensin_II in the ECV304 cell line .
15802625	0	NF-kappaB	68,77	angiotensin_II	39,53	NF-kappaB	angiotensin II	4790	183	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	A new cellular signaling mechanism for angiotensin_II activation of NF-kappaB : An IkappaB-independent , RSK-mediated phosphorylation of p65 .
24988892	0	NF-kappaB	97,106	ataxia-telangiectasia_mutated	67,96	NF-kappaB	ataxia-telangiectasia mutated	4790	472	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Interleukin_6 augments lung_cancer chemotherapeutic resistance via ataxia-telangiectasia_mutated / NF-kappaB pathway activation .
10216101	0	NF-kappaB	8,17	bcl-2	99,104	NF-kappaB	bcl-2	4790	596	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|apoptosis apoptosis|nmod|END_ENTITY	Role of NF-kappaB in the rescue of multiple_myeloma cells from glucocorticoid-induced apoptosis by bcl-2 .
10738245	0	NF-kappaB	31,40	bcl-2	0,5	NF-kappaB	bcl-2	4790	596	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|over-expression over-expression|amod|END_ENTITY	bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7 -LRB- ADR -RRB- breast-cancer cells .
10807870	0	NF-kappaB	146,155	bcl-2	89,94	NF-kappaB	bcl-2	4790	596	Gene	Gene	importance|nmod|START_ENTITY evidence|nmod|importance suppression|nmod|evidence suppression|amod|END_ENTITY	Hypoxia-induced endothelial apoptosis through nuclear_factor-kappaB -LRB- NF-kappaB -RRB- - mediated bcl-2 suppression : in vivo evidence of the importance of NF-kappaB in endothelial cell regulation .
10807870	0	NF-kappaB	69,78	bcl-2	89,94	NF-kappaB	bcl-2	4790	596	Gene	Gene	nuclear_factor-kappaB|appos|START_ENTITY apoptosis|nmod|nuclear_factor-kappaB apoptosis|dep|suppression suppression|amod|END_ENTITY	Hypoxia-induced endothelial apoptosis through nuclear_factor-kappaB -LRB- NF-kappaB -RRB- - mediated bcl-2 suppression : in vivo evidence of the importance of NF-kappaB in endothelial cell regulation .
18486908	0	NF-kappaB	96,105	bcl-2	129,134	NF-kappaB	bcl-2	18033(Tax:10090)	12043(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|cells cells|amod|END_ENTITY	Ursolic_acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells .
12459462	0	NF-kappaB	33,42	bcl-x	50,55	NF-kappaB	bcl-x	18033(Tax:10090)	12048(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Bruton 's _ tyrosine_kinase targets NF-kappaB to the bcl-x promoter via a mechanism involving phospholipase_C-gamma2 following B_cell_antigen_receptor engagement .
11817569	0	NF-kappaB	22,31	c-fos	41,46	NF-kappaB	c-fos	18033(Tax:10090)	14281(Tax:10090)	Gene	Gene	factors|amod|START_ENTITY /|nsubj|factors /|dobj|END_ENTITY	Transcription factors NF-kappaB and AP-1 / c-fos in cell response to nocodazole .
18762893	0	NF-kappaB	158,167	c-fos	191,196	NF-kappaB	c-fos	18033(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Effect of thermal_injury on LPS-mediated Toll signaling pathways by murine peritoneal macrophages : inhibition of DNA-binding of transcription factor AP-1 and NF-kappaB and gene expression of c-fos and IL-12p40 .
10585438	0	NF-kappaB	0,9	cAMP-response_element-binding_protein	18,55	NF-kappaB	cAMP-response element-binding protein	18033(Tax:10090)	12912(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	NF-kappaB induces cAMP-response_element-binding_protein gene transcription in sertoli cells .
18694378	0	NF-kappaB	0,9	carcinoma	13,22	NF-kappaB	NF-kappaB	4790	4790	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	NF-kappaB in carcinoma therapy and prevention .
10799332	0	NF-kappaB	80,89	caspase-8	32,41	NF-kappaB	caspase-8	4790	841	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Adenovirus-mediated transfer of caspase-8 in combination with superrepressor of NF-kappaB drastically induced apoptosis in gliomas .
18504428	0	NF-kappaB	51,60	cyclin_D2	18,27	NF-kappaB	cyclin D2	4790	894	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Activation of the cyclin_D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax .
10454683	0	NF-kappaB	33,42	cyclooxygenase-2	92,108	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells .
11162356	0	NF-kappaB	9,18	cyclooxygenase-2	58,74	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	activation|amod|START_ENTITY prohibits|nsubj|activation prohibits|dobj|expression expression|amod|END_ENTITY	Blockade NF-kappaB activation prohibits TNF-alpha-induced cyclooxygenase-2 gene expression in ED27 trophoblast-like cells .
11853875	0	NF-kappaB	19,28	cyclooxygenase-2	67,83	NF-kappaB	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|overexpression overexpression|nmod|END_ENTITY	The involvement of NF-kappaB in the constitutive overexpression of cyclooxygenase-2 in cyclooxygenase-1 null cells .
12349896	0	NF-kappaB	99,108	cyclooxygenase-2	31,47	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	activation|amod|START_ENTITY suppression|nmod|activation amentoflavone|nmod|suppression cells|amod|amentoflavone Inhibition|nmod|cells Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells .
12485900	0	NF-kappaB	107,116	cyclooxygenase-2	72,88	NF-kappaB	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of selected ginsenosides on phorbol_ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin .
12860389	0	NF-kappaB	33,42	cyclooxygenase-2	87,103	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	activation|nmod|START_ENTITY mediates|nsubj|activation mediates|dobj|release release|nmod|expression expression|nmod|synthase synthase|amod|END_ENTITY	IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin_E synthase .
14630924	0	NF-kappaB	22,31	cyclooxygenase-2	190,206	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	activation|amod|START_ENTITY activation|dep|abrogation abrogation|nmod|END_ENTITY	Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation : abrogation of cyclin_D1 , cyclooxygenase-2 , and matrix metalloprotease-9 .
14633657	0	NF-kappaB	88,97	cyclooxygenase-2	35,51	NF-kappaB	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|nmod|END_ENTITY	Nitric_oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB .
15020231	0	NF-kappaB	66,75	cyclooxygenase-2	13,29	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 in macrophages by catalase : role of NF-kappaB and PI3K signaling pathways .
15655349	0	NF-kappaB	95,104	cyclooxygenase-2	27,43	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	nuclear_factor-kappa_B|appos|START_ENTITY expression|nmod|nuclear_factor-kappa_B expression|amod|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
16336399	0	NF-kappaB	83,92	cyclooxygenase-2	118,134	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Aspirin induces apoptosis in oesophageal_cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2 .
17403674	0	NF-kappaB	89,98	cyclooxygenase-2	43,59	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett 's esophageal_adenocarcinoma cells .
19160097	0	NF-kappaB	80,89	cyclooxygenase-2	115,131	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	NS-398 induces apoptosis in human esophageal_cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2 .
19618291	0	NF-kappaB	96,105	cyclooxygenase-2	61,77	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Toll-like_receptor_9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate_cancer cells .
22803374	0	NF-kappaB	11,20	cyclooxygenase-2	70,86	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	-LSB- Effect of NF-kappaB on inhibition of non-small_cell_lung_cancer cell cyclooxygenase-2 by brucine -RSB- .
8995303	0	NF-kappaB	41,50	cyclooxygenase-2	16,32	NF-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	factor|amod|START_ENTITY END_ENTITY|nmod|factor	Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells .
9414121	0	NF-kappaB	15,24	cyclooxygenase-2	46,62	NF-kappaB	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages .
15355306	0	NF-kappaB	44,53	eIF2alpha	24,33	NF-kappaB	eIF2alpha	4790	83939	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation .
9722548	0	NF-kappaB	8,17	endothelin-1	53,65	NF-kappaB	endothelin-1	4790	1906	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|effect effect|nmod|END_ENTITY	Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor_necrosis_factor-alpha in human hepatic_stellate cells .
14701753	0	NF-kappaB	99,108	epidermal_growth_factor_receptor	66,98	NF-kappaB	epidermal growth factor receptor	4790	1956	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Distinct domains in the SHP-2 phosphatase differentially regulate epidermal_growth_factor_receptor / NF-kappaB activation through Gab1 in glioblastoma cells .
18541671	0	NF-kappaB	87,96	epidermal_growth_factor_receptor	19,51	NF-kappaB	epidermal growth factor receptor	4790	1956	Gene	Gene	signaling|xcomp|START_ENTITY role|acl|signaling role|nmod|END_ENTITY	Essential role for epidermal_growth_factor_receptor in glutamate receptor signaling to NF-kappaB .
11495725	0	NF-kappaB	39,48	erythropoietin	56,70	NF-kappaB	erythropoietin	4790	2056	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Activation of the transcription factor NF-kappaB by the erythropoietin receptor : structural requirements and biological significance .
12482504	0	NF-kappaB	0,9	erythropoietin	67,81	NF-kappaB	erythropoietin	4790	2056	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|expression expression|compound|END_ENTITY	NF-kappaB plays a key role in hypoxia-inducible_factor-1-regulated erythropoietin gene expression .
20353839	0	NF-kappaB	14,23	focal_adhesion_kinase	75,96	NF-kappaB	focal adhesion kinase	4790	5747	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of NF-kappaB by fluid_shear_stress , but not TNF-alpha , requires focal_adhesion_kinase in osteoblasts .
15721278	0	NF-kappaB	14,23	gadd45alpha	35,46	NF-kappaB	gadd45alpha	18033(Tax:10090)	13197(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY stabilizes|nsubj|Inhibition stabilizes|dobj|mRNA mRNA|amod|END_ENTITY	Inhibition of NF-kappaB stabilizes gadd45alpha mRNA .
18073186	0	NF-kappaB	42,51	heme_oxygenase-1	15,31	NF-kappaB	heme oxygenase-1	18033(Tax:10090)	15368(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Statin-induced heme_oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide .
19317804	0	NF-kappaB	0,9	iNOS	19,23	NF-kappaB	iNOS	4790	4843	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid_cystic_carcinoma cells and enhances endothelial cell motility in vitro .
9824673	0	NF-kappaB	14,23	iNOS	25,29	NF-kappaB	iNOS	4790	4843	Gene	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of NF-kappaB , iNOS mRNA , COX2 mRNA , and COX catalytic activity by phenyl-N-tert-butylnitrone -LRB- PBN -RRB- .
10594073	0	NF-kappaB	52,61	interleukin-1beta	21,38	NF-kappaB	interleukin-1beta	18033(Tax:10090)	16176(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia .
10638705	0	NF-kappaB	50,59	interleukin-8	80,93	NF-kappaB	interleukin-8	4790	3576	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic_adenocarcinoma cells by hypoxia .
11254628	0	NF-kappaB	60,69	interleukin-8	82,95	NF-kappaB	interleukin-8	4790	3576	Gene	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	Subcytocidal attack by staphylococcal alpha-toxin activates NF-kappaB and induces interleukin-8 production .
19448676	0	NF-kappaB	90,99	interleukin-8	50,63	NF-kappaB	interleukin-8	4790	3576	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	CHFR , a potential tumor suppressor , downregulates interleukin-8 through the inhibition of NF-kappaB .
14673102	0	NF-kappaB	59,68	latent_membrane_protein_1	19,44	NF-kappaB	latent membrane protein 1	4790	9260	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 activation of NF-kappaB through IRAK1 and TRAF6 .
16979873	0	NF-kappaB	138,147	latent_membrane_protein_1	74,99	NF-kappaB	latent membrane protein 1	4790	9260	Gene	Gene	pathways|compound|START_ENTITY cells|nmod|pathways encoded|nmod|cells encoded|dobj|END_ENTITY	Upregulated expression of kappa light chain by Epstein-Barr_virus encoded latent_membrane_protein_1 in nasopharyngeal_carcinoma cells via NF-kappaB and AP-1 pathways .
20923877	0	NF-kappaB	71,80	latent_membrane_protein_1	13,38	NF-kappaB	latent membrane protein 1	4790	9260	Gene	Gene	activates|xcomp|START_ENTITY activates|nsubj|site site|amod|END_ENTITY	Epstein-Barr latent_membrane_protein_1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419 .
20923877	0	NF-kappaB	99,108	latent_membrane_protein_1	13,38	NF-kappaB	latent membrane protein 1	4790	9260	Gene	Gene	residues|amod|START_ENTITY absence|nmod|residues NF-kappaB|nmod|absence activates|xcomp|NF-kappaB activates|nsubj|site site|amod|END_ENTITY	Epstein-Barr latent_membrane_protein_1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419 .
14597166	0	NF-kappaB	0,9	macrophage_inflammatory_protein-2	44,77	NF-kappaB	macrophage inflammatory protein-2	18033(Tax:10090)	20310(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	NF-kappaB and c-Jun-dependent regulation of macrophage_inflammatory_protein-2 gene expression in response to lipopolysaccharide in RAW 264.7 cells .
10580107	0	NF-kappaB	172,181	matrix_metalloproteinase-9	43,69	NF-kappaB	matrix metalloproteinase-9	4790	4318	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Human_immunodeficiency_virus-1-tat induces matrix_metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB .
15800029	0	NF-kappaB	124,133	matrix_metalloproteinase-9	14,40	NF-kappaB	matrix metalloproteinase-9	4790	4318	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|Production Production|nmod|END_ENTITY	Production of matrix_metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha / NF-kappaB pathway .
17922642	0	NF-kappaB	192,201	matrix_metalloproteinase-9	14,40	NF-kappaB	matrix metalloproteinase-9	4790	4318	Gene	Gene	expression|nmod|START_ENTITY role|nmod|expression Regulation|dep|role Regulation|nmod|transcription transcription|amod|END_ENTITY	Regulation of matrix_metalloproteinase-9 transcription in squamous_cell_carcinoma of uterine cervix : the role of human_papillomavirus gene E2 expression and activation of transcription factor NF-kappaB .
18753206	0	NF-kappaB	46,55	miR-155	27,34	NF-kappaB	miR-155	4790	406947	Gene	Gene	START_ENTITY|nsubj|attenuates attenuates|amod|END_ENTITY	Epstein-Barr_virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence .
18692059	0	NF-kappaB	0,9	netrin-1	20,28	NF-kappaB	Netrin-1	18033(Tax:10090)	18208(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors .
11108147	0	NF-kappaB	108,117	nuclear_factor-kappaB	85,106	NF-kappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Angiotensin_II induces gene transcription through cell-type-dependent effects on the nuclear_factor-kappaB -LRB- NF-kappaB -RRB- transcription factor .
11322928	0	NF-kappaB	37,46	nuclear_factor-kappaB	14,35	NF-kappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Alteration of nuclear_factor-kappaB -LRB- NF-kappaB -RRB- expression in bone marrow stromal cells treated with etoposide .
16850495	0	NF-kappaB	39,48	nuclear_factor-kappaB	16,37	NF-kappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of nuclear_factor-kappaB -LRB- NF-kappaB -RRB- is related to the grade of cervical_intraepithelial_neoplasia , but is not an independent predictor of high-risk human_papillomavirus or disease outcome in cervical_cancer .
18365680	0	NF-kappaB	121,130	nuclear_factor-kappaB	98,119	NF-kappaB	nuclear factor-kappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Synthesis of chroman-2-carboxylic_acid_N - -LRB- substituted -RRB- phenylamides and their inhibitory effect on nuclear_factor-kappaB -LRB- NF-kappaB -RRB- activation .
20068038	0	NF-kappaB	186,195	nuclear_factor-kappaB	163,184	NF-kappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic_acid-mediated optimal IkappaB_kinase_beta -LRB- IKKbeta -RRB- / nuclear_factor-kappaB -LRB- NF-kappaB -RRB- activation .
20415419	0	NF-kappaB	157,166	nuclear_factor-kappaB	134,155	NF-kappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	5-Hydroxytrytophan inhibits tert-butylhydroperoxide -LRB- t-BHP -RRB- - induced oxidative damage via the suppression of reactive species -LRB- RS -RRB- and nuclear_factor-kappaB -LRB- NF-kappaB -RRB- activation on human fibroblast .
20446732	0	NF-kappaB	94,103	nuclear_factor-kappaB	71,92	NF-kappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Enterodiol and enterolactone modulate the immune response by acting on nuclear_factor-kappaB -LRB- NF-kappaB -RRB- signaling .
11377405	0	NF-kappaB	39,48	nuclear_factor-kappa_B	15,37	NF-kappaB	nuclear factor-kappa B	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Involvement of nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activation in mitogen-induced lymphocyte proliferation : inhibitory effects of lymphoproliferation by salicylates acting as NF-kappaB inhibitors .
17499901	0	NF-kappaB	182,191	nuclear_factor-kappa_B	158,180	NF-kappaB	nuclear factor-kappa B	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Dexamethasone protects RAW264 .7 macrophages from growth arrest and apoptosis induced by H2O2 through alteration of gene expression patterns and inhibition of nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activity .
19617655	0	NF-kappaB	107,116	nuclear_factor-kappa_B	83,105	NF-kappaB	nuclear factor-kappa B	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activation .
20398679	0	NF-kappaB	42,51	nuclear_factor-kappa_B	18,40	NF-kappaB	nuclear factor-kappa B	4790	4790	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Downregulation of nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- pathway by silibinin in human monocytes challenged with Paracoccidioides_brasiliensis .
19343319	0	NF-kappaB	95,104	nuclear_factor_kappa-B	71,93	NF-kappaB	nuclear factor kappa-B	4790	4790	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear_factor_kappa-B -LRB- NF-kappaB -RRB- signalling in human islets and in a mouse beta cell line .
10336492	0	NF-kappaB	33,42	nuclear_factor_kappaB	10,31	NF-kappaB	nuclear factor kappaB	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Transient nuclear_factor_kappaB -LRB- NF-kappaB -RRB- activation stimulated by interleukin-1beta may be partly dependent on proteasome activity , but not phosphorylation and ubiquitination of the IkappaBalpha molecule , in C6_glioma cells .
15811753	0	NF-kappaB	51,60	nuclear_factor_kappa_B	27,49	NF-kappaB	nuclear factor kappa B	4790	4790	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Cellular_death mediated by nuclear_factor_kappa_B -LRB- NF-kappaB -RRB- translocation in cultured human lens epithelial cells after ultraviolet-B irradiation .
9822350	0	NF-kappaB	38,47	nuclear_factor_kappa_B	14,36	NF-kappaB	nuclear factor kappa B	4790	4790	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of nuclear_factor_kappa_B -LRB- NF-kappaB -RRB- assayed by laser scanning cytometry -LRB- LSC -RRB- .
11087273	0	NF-kappaB	85,94	p38	61,64	NF-kappaB	p38	4790	1432	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	HIV gp120 enhances NO production by cardiac myocytes through p38 MAP kinase-mediated NF-kappaB activation .
11110796	0	NF-kappaB	53,62	p40	81,84	NF-kappaB	p40	18033(Tax:10090)	16160(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells .
11714266	0	NF-kappaB	40,49	p50	25,28	NF-kappaB	p50	4790	4790	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Glutathionylation of the p50 subunit of NF-kappaB : a mechanism for redox-induced inhibition of DNA binding .
15201435	0	NF-kappaB	161,170	p50	121,124	NF-kappaB	p50	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Effect of 2,2 ' ,4,4 ' ,5,5 ' - hexachlorobiphenyl -LRB- PCB-153 -RRB- on hepatocyte proliferation and apoptosis in mice deficient in the p50 subunit of the transcription factor NF-kappaB .
16793936	0	NF-kappaB	60,69	p50	70,73	NF-kappaB	p50	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Spontaneous , homeostatic , and inflammation-induced sleep in NF-kappaB p50 knockout mice .
18694964	0	NF-kappaB	19,28	p50	4,7	NF-kappaB	p50	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter_rodentium .
19806632	0	NF-kappaB	30,39	p50	26,29	NF-kappaB	p50	4790	4790	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Virtual screening against p50 NF-kappaB transcription factor for the identification of inhibitors of the NF-kappaB-DNA interaction and expression of NF-kappaB upregulated genes .
20086086	0	NF-kappaB	4,13	p50	14,17	NF-kappaB	p50	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	The NF-kappaB p50 subunit is protective during intestinal Entamoeba_histolytica infection of 129 and C57BL/6 mice .
15073170	0	NF-kappaB	12,21	p53	0,3	NF-kappaB	p53	4790	7157	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal_S6_kinase_1 .
17132229	0	NF-kappaB	22,31	p53	15,18	NF-kappaB	p53	4790	7157	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma .
20600004	0	NF-kappaB	100,109	p53	84,87	NF-kappaB	p53	4790	7157	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Transcriptional suppression of breast_cancer_resistance_protein -LRB- BCRP -RRB- by wild-type p53 through the NF-kappaB pathway in MCF-7 cells .
10521409	0	NF-kappaB	30,39	p65	40,43	NF-kappaB	p65	4790	5970	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain .
10773449	0	NF-kappaB	20,29	p65	4,7	NF-kappaB	p65	4790	5970	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The p65 domain from NF-kappaB is an efficient human activator in the tetracycline-regulatable gene expression system .
11564889	0	NF-kappaB	26,35	p65	4,7	NF-kappaB	p65	4790	5970	Gene	Gene	interacts|amod|START_ENTITY subunit|nmod|interacts subunit|compound|END_ENTITY	The p65 -LRB- RelA -RRB- subunit of NF-kappaB interacts with the histone_deacetylase -LRB- HDAC -RRB- corepressors HDAC1 and HDAC2 to negatively regulate gene expression .
14600157	0	NF-kappaB	147,156	p65	131,134	NF-kappaB	p65	4790	5970	Gene	Gene	subunit|nmod|START_ENTITY subunit|appos|END_ENTITY	Fas-associated_factor-1 inhibits nuclear factor-kappaB -LRB- NF-kappaB -RRB- activity by interfering with nuclear translocation of the RelA -LRB- p65 -RRB- subunit of NF-kappaB .
14600157	0	NF-kappaB	56,65	p65	131,134	NF-kappaB	p65	4790	5970	Gene	Gene	activity|dep|START_ENTITY inhibits|dobj|activity inhibits|advcl|interfering interfering|nmod|translocation translocation|nmod|subunit subunit|appos|END_ENTITY	Fas-associated_factor-1 inhibits nuclear factor-kappaB -LRB- NF-kappaB -RRB- activity by interfering with nuclear translocation of the RelA -LRB- p65 -RRB- subunit of NF-kappaB .
15073170	0	NF-kappaB	12,21	p65	105,108	NF-kappaB	p65	4790	5970	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nmod|mechanism mechanism|acl|involving involving|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal_S6_kinase_1 .
15506973	0	NF-kappaB	45,54	p65	40,43	NF-kappaB	p65	4790	5970	Gene	Gene	START_ENTITY|nsubj|modification modification|appos|END_ENTITY	Post-translational modification of RelA -LRB- p65 -RRB- NF-kappaB .
15802625	0	NF-kappaB	68,77	p65	135,138	NF-kappaB	p65	4790	5970	Gene	Gene	activation|nmod|START_ENTITY mechanism|nmod|activation mechanism|dep|phosphorylation phosphorylation|nmod|END_ENTITY	A new cellular signaling mechanism for angiotensin_II activation of NF-kappaB : An IkappaB-independent , RSK-mediated phosphorylation of p65 .
15980040	0	NF-kappaB	114,123	p65	124,127	NF-kappaB	p65	4790	5970	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation .
16624823	0	NF-kappaB	61,70	p65	142,145	NF-kappaB	p65	4790	5970	Gene	Gene	activation|amod|START_ENTITY suppresses|dobj|activation suppresses|nmod|modulation modulation|nmod|activation activation|compound|END_ENTITY	Plumbagin -LRB- 5-hydroxy-2-methyl-1 ,4 - naphthoquinone -RRB- suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation , leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents .
16636680	0	NF-kappaB	129,138	p65	125,128	NF-kappaB	p65	4790	5970	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Nuclear BCL-10 expression is common in lymphoplasmacytic_lymphoma / Waldenstr m macroglobulinemia and does not correlate with p65 NF-kappaB activation .
17530443	0	NF-kappaB	42,51	p65	18,21	NF-kappaB	p65	4790	5970	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor_necrosis_factor-alpha .
17982104	0	NF-kappaB	118,127	p65	155,158	NF-kappaB	p65	4790	5970	Gene	Gene	inactivating|dobj|START_ENTITY inactivating|nmod|suppression suppression|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation .
19789307	0	NF-kappaB	8,17	p65	18,21	NF-kappaB	p65	4790	5970	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head_and_neck_cancer .
19864627	0	NF-kappaB	14,23	p65	67,70	NF-kappaB	p65	4790	5970	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of NF-kappaB activity through lysine monomethylation of p65 .
20001970	0	NF-kappaB	44,53	p65	39,42	NF-kappaB	p65	18033(Tax:10090)	19697(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|RelA RelA|appos|END_ENTITY	Thr435 phosphorylation regulates RelA -LRB- p65 -RRB- NF-kappaB subunit transactivation .
20080798	0	NF-kappaB	14,23	p65	82,85	NF-kappaB	p65	4790	5970	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|methylation methylation|nmod|END_ENTITY	Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65 .
20823682	0	NF-kappaB	117,126	p65	148,151	NF-kappaB	p65	18033(Tax:10090)	19697(Tax:10090)	Gene	Gene	recruitment|amod|START_ENTITY recruitment|amod|END_ENTITY	Amelioration of dextran sulfate_sodium-induced chronic_colitis by sulfasalazine_salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters .
23489828	0	NF-kappaB	15,24	p65	25,28	NF-kappaB	p65	18033(Tax:10090)	19697(Tax:10090)	Gene	Gene	attenuates|amod|START_ENTITY attenuates|amod|END_ENTITY	Suppression of NF-kappaB p65 expression attenuates delayed xenograft rejection .
8995303	0	NF-kappaB	41,50	p65	51,54	NF-kappaB	p65	4790	5970	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells .
9315679	0	NF-kappaB	92,101	p65	78,81	NF-kappaB	p65	4790	5970	Gene	Gene	transcription|amod|START_ENTITY mediated|dobj|transcription mediated|nsubj|member member|nmod|epsilon epsilon|appos|RelA RelA|appos|END_ENTITY	A new member of the I kappaB protein family , I kappaB epsilon , inhibits RelA -LRB- p65 -RRB- - mediated NF-kappaB transcription .
9405476	0	NF-kappaB	43,52	p65	137,140	NF-kappaB	p65	4790	5970	Gene	Gene	factor|acl|START_ENTITY Activation|nmod|factor accompanied|nsubjpass|Activation accompanied|nmod|phosphorylation phosphorylation|nmod|subunit subunit|amod|END_ENTITY	Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein_kinase_II-mediated phosphorylation of the p65 subunit .
9412459	0	NF-kappaB	49,58	p65	125,128	NF-kappaB	p65	4790	5970	Gene	Gene	activates|dobj|START_ENTITY activates|advcl|targeting targeting|dobj|END_ENTITY	Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65 .
9837931	0	NF-kappaB	88,97	p65	120,123	NF-kappaB	p65	4790	5970	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	The anti-inflammatory sesquiterpene_lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65 .
19173301	0	NF-kappaB	35,44	protein_kinase_D1	77,94	NF-kappaB	protein kinase D1	4790	5587	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein_kinase_D1 .
12816868	0	NF-kappaB	0,9	tal-1	43,48	NF-kappaB	tal-1	18033(Tax:10090)	21349(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	NF-kappaB activation in premalignant mouse tal-1 / scl thymocytes and tumors .
10572100	0	NF-kappaB	65,74	tax	40,43	NF-kappaB	tax	4790	1491938(Tax:11908)	Gene	Gene	translocation|amod|START_ENTITY induction|nmod|translocation cascade|nmod|induction cascade|nmod|END_ENTITY	Inhibition of caspase cascade by HTLV-I tax through induction of NF-kappaB nuclear translocation .
14963024	0	NF-kappaB	76,85	tax	39,42	NF-kappaB	tax	4790	6900	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Human_T-cell_lymphotropic_virus_type_1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65 .
16287853	0	NF-kappaB	80,89	tax	136,139	NF-kappaB	tax	4790	6900	Gene	Gene	activation|amod|START_ENTITY mediate|dobj|activation mediate|nmod|oncoprotein oncoprotein|compound|END_ENTITY	Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell_leukemia_virus tax oncoprotein .
8628274	0	NF-kappaB	138,147	tax	35,38	NF-kappaB	tax	4790	1491938(Tax:11908)	Gene	Gene	induction|nmod|START_ENTITY mechanism|nmod|induction Inactivation|dep|mechanism Inactivation|nmod|IkappaBbeta IkappaBbeta|nmod|protein protein|compound|END_ENTITY	Inactivation of IkappaBbeta by the tax protein of human_T-cell_leukemia_virus_type_1 : a potential mechanism for constitutive induction of NF-kappaB .
11063742	0	NF-kappaB	98,107	thioredoxin	83,94	NF-kappaB	thioredoxin	4790	7295	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	c-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB : role of thioredoxin in NF-kappaB activation .
14669993	0	NF-kappaB	21,30	thioredoxin	82,93	NF-kappaB	thioredoxin	4790	7295	Gene	Gene	action|nmod|START_ENTITY results|nsubj|action results|nmod|levels levels|nmod|END_ENTITY	Suboptimal action of NF-kappaB in Fanconi_anemia cells results from low levels of thioredoxin .
15581626	0	NF-kappaB	0,9	thioredoxin	81,92	NF-kappaB	thioredoxin	4790	7295	Gene	Gene	activation|amod|START_ENTITY prevents|nsubj|activation prevents|dobj|stress stress|nmod|increase increase|nmod|END_ENTITY	NF-kappaB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFalpha-treated Ewing_sarcoma cells .
9388242	0	NF-kappaB	60,69	thioredoxin	34,45	NF-kappaB	thioredoxin	4790	7295	Gene	Gene	activation|amod|START_ENTITY peroxidase|nmod|activation peroxidase|nsubj|role role|nmod|END_ENTITY	Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation .
15388451	0	NF-kappaB	108,117	toll-like_receptor_2	62,82	NF-kappaB	toll-like receptor 2	4790	7097	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 protease inhibitors block toll-like_receptor_2 -LRB- TLR2 -RRB- - and TLR4-Induced NF-kappaB activation .
25887269	0	NF-kappaB	90,99	toll-like_receptor_4	69,89	NF-kappaB	toll-like receptor 4	4790	7099	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Daidzein attenuates lipopolysaccharide-induced acute_lung_injury via toll-like_receptor_4 / NF-kappaB pathway .
19738286	0	NF-kappaB	62,71	tristetraprolin	25,40	NF-kappaB	tristetraprolin	18033(Tax:10090)	22695(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RNA-destabilizing factor tristetraprolin negatively regulates NF-kappaB signaling .
11450703	0	NF-kappaB	141,150	tumor_necrosis_factor_alpha	170,197	NF-kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	cells|nmod|START_ENTITY HCS-2|dep|cells HCS-2|dep|abrogation abrogation|nmod|effect effect|compound|END_ENTITY	Tumor_necrosis_factor_alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2 / 8 cells through activation of NF-kappaB : abrogation of the tumor_necrosis_factor_alpha effect by proteasome inhibitors .
17481363	0	NF-kappaB	29,38	tumor_necrosis_factor_alpha	64,91	NF-kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	translocation|amod|START_ENTITY Analysis|nmod|translocation Analysis|nmod|cells cells|amod|END_ENTITY	Analysis and quantitation of NF-kappaB nuclear translocation in tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- activated vascular endothelial cells .
19211746	0	NF-kappaB	93,102	tumor_necrosis_factor_alpha	117,144	NF-kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY suppress|dobj|activation suppress|nmod|END_ENTITY	Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor_necrosis_factor_alpha but is independent of its host range function .
21715489	0	NF-kappaB	0,9	tumor_necrosis_factor_alpha	95,122	NF-kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|keratinocytes keratinocytes|nmod|apoptosis apoptosis|compound|END_ENTITY	NF-kappaB protects human papillomavirus type 38 E6/E7-immortalized human keratinocytes against tumor_necrosis_factor_alpha and UV-mediated apoptosis .
9653166	0	NF-kappaB	140,149	tumor_necrosis_factor_alpha	74,101	NF-kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|production production|compound|END_ENTITY	Efficient adenoviral_infection with IkappaB_alpha reveals that macrophage tumor_necrosis_factor_alpha production in rheumatoid_arthritis is NF-kappaB dependent .
16809323	0	NF-kappaB	14,23	vFLIP	38,43	NF-kappaB	vFLIP	4790	4961494(Tax:37296)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Activation of NF-kappaB by the latent vFLIP gene of Kaposi 's _ sarcoma-associated_herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype .
9520446	0	NF-kappaB-inducing_kinase	0,25	IKK-alpha	36,45	NF-kappaB-inducing kinase	IKK-alpha	9020	1147	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	NF-kappaB-inducing_kinase activates IKK-alpha by phosphorylation of Ser-176 .
10648614	0	NF-kappaB-inducing_kinase	95,120	NF-kappaB	0,9	NF-kappaB-inducing kinase	NF-kappaB	9020	4790	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|activation activation|amod|END_ENTITY	NF-kappaB activation by double-stranded-RNA-activated protein kinase -LRB- PKR -RRB- is mediated through NF-kappaB-inducing_kinase and IkappaB kinase .
18025233	0	NF-kappaB-inducing_kinase	0,25	cyclooxygenase_2	36,52	NF-kappaB-inducing kinase	cyclooxygenase 2	9020	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	NF-kappaB-inducing_kinase regulates cyclooxygenase_2 gene expression in macrophages by phosphorylation of PU .1 .
15140882	0	NF-kappaB-inducing_kinase	32,57	p100	13,17	NF-kappaB-inducing kinase	p100	9020	4791	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Induction of p100 processing by NF-kappaB-inducing_kinase involves docking IkappaB_kinase_alpha -LRB- IKKalpha -RRB- to p100 and IKKalpha-mediated phosphorylation .
15364010	0	NF-kappaB1	19,29	p50	31,34	NF-kappaB1	p50	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Protective role of NF-kappaB1 -LRB- p50 -RRB- in experimental_pneumococcal_meningitis .
17405906	0	NF-kappaB2	0,10	TRAF1	28,33	NF-kappaB2	TRAF1	18034(Tax:10090)	22029(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis .
20580552	0	NF-kappaB_inducing_kinase	0,25	NIK	27,30	NF-kappaB inducing kinase	NIK	9020	9020	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	NF-kappaB_inducing_kinase -LRB- NIK -RRB- inhibitors : identification of new scaffolds using virtual screening .
18987666	0	NF-kappaB_p50	121,134	bcl-2	148,153	NF-kappaB p50	bcl-2	18033(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	C/EBPalpha or C/EBPalpha oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-kappaB_p50 bound to the bcl-2 and FLIP gene promoters .
17485464	0	NF-kappaB_p50	0,13	receptor_activator_of_NF-kappaB_ligand	31,69	NF-kappaB p50	receptor activator of NF-kappaB ligand	4790	8600	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	NF-kappaB_p50 and p52 regulate receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- and tumor_necrosis_factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1 .
10517905	0	NF-kappaBp65	57,69	IkappaBalpha	70,82	NF-kappaBp65	IkappaBalpha	5970	4792	Gene	Gene	effects|nmod|START_ENTITY effects|dep|system system|compound|END_ENTITY	Cell specific effects of glucocorticoid treatment on the NF-kappaBp65 / IkappaBalpha system in patients with Crohn 's _ disease .
12586352	0	NF-kappa_B	60,70	ABIN-1	83,89	NF-kappa B	ABIN-1	4790	10318	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Structure-function analysis of the A20-binding inhibitor of NF-kappa_B activation , ABIN-1 .
10984605	0	NF-kappa_B	51,61	Akt	13,16	NF-kappa B	Akt	4790	207	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	PDGF-induced Akt phosphorylation does not activate NF-kappa_B in human vascular smooth_muscle_cells and fibroblasts .
11259436	0	NF-kappa_B	72,82	Akt	0,3	NF-kappa B	Akt	4790	207	Gene	Gene	p38|amod|START_ENTITY Subunit|nmod|p38 potential|nmod|Subunit stimulates|dobj|potential stimulates|nsubj|END_ENTITY	Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa_B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38 .
11976320	0	NF-kappa_B	41,51	Akt	132,135	NF-kappa B	Akt	4790	207	Gene	Gene	activation|amod|START_ENTITY induced|dobj|activation interleukin-1beta|acl|induced Inhibition|nmod|interleukin-1beta occurs|nsubj|Inhibition occurs|nmod|activation activation|compound|END_ENTITY	Inhibition of interleukin-1beta - induced NF-kappa_B activation by calcium/calmodulin-dependent _ protein_kinase_kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88 .
12052823	0	NF-kappa_B	30,40	Akt	0,3	NF-kappa B	Akt	18033(Tax:10090)	11651(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Akt is a downstream target of NF-kappa_B .
12649266	0	NF-kappa_B	113,123	Akt	136,139	NF-kappa B	Akt	4790	207	Gene	Gene	activation|nmod|START_ENTITY involves|dobj|activation involves|nmod|pathway pathway|compound|END_ENTITY	Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa_B through the Akt pathway .
12682234	0	NF-kappa_B	18,28	Akt	159,162	NF-kappa B	Akt	4790	207	Gene	Gene	X-ray-inducible|amod|START_ENTITY Expression|nmod|X-ray-inducible response|amod|Expression enhances|nsubj|response enhances|advcl|inhibiting inhibiting|dobj|activation activation|compound|END_ENTITY	Expression of the NF-kappa_B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation .
17097193	0	NF-kappa_B	23,33	Angiotensin_II	0,14	NF-kappa B	Angiotensin II	4790	183	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Angiotensin_II induces NF-kappa_B activation in HUVEC via the p38MAPK pathway .
15048072	0	NF-kappa_B	102,112	Bcl-xl	131,137	NF-kappa B	Bcl-xl	4790	598	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Nitric_oxide sensitizes prostate_carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa_B and inhibition of Bcl-xl expression .
9583684	0	NF-kappa_B	64,74	C15	16,19	NF-kappa B	C15	4790	51316	Gene	Gene	activation|nmod|START_ENTITY confers|dobj|activation confers|nsubj|protein protein|compound|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
11278692	0	NF-kappa_B	160,170	CARD11	0,6	NF-kappa B	CARD11	4790	84433	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	CARD11 and CARD14 are novel caspase recruitment domain -LRB- CARD -RRB- / membrane-associated guanylate kinase -LRB- MAGUK -RRB- family members that interact with BCL10 and activate NF-kappa_B .
12154356	0	NF-kappa_B	40,50	CARMA1	18,24	NF-kappa B	CARMA1	4790	84433	Gene	Gene	activation|amod|START_ENTITY requirement|nmod|activation requirement|nmod|END_ENTITY	A requirement for CARMA1 in TCR-induced NF-kappa_B activation .
12154360	0	NF-kappa_B	68,78	CARMA1	0,6	NF-kappa B	CARMA1	4790	84433	Gene	Gene	activation|amod|START_ENTITY regulator|nmod|activation regulator|nsubj|END_ENTITY	CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa_B activation .
12867038	0	NF-kappa_B	51,61	CARMA1	16,22	NF-kappa B	CARMA1	18033(Tax:10090)	108723(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Requirement for CARMA1 in antigen receptor-induced NF-kappa_B activation and lymphocyte proliferation .
14993411	0	NF-kappa_B	27,37	CARMA1	63,69	NF-kappa B	CARMA1	4790	84433	Gene	Gene	destiny|nmod|START_ENTITY Determining|dobj|destiny Determining|parataxis|END_ENTITY	Determining the destiny of NF-kappa_B after TCR ligation : it 's CARMA1 .
11175263	0	NF-kappa_B	12,22	CD4	69,72	NF-kappa B	CD4	18033(Tax:10090)	12504(Tax:10090)	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|CD8 CD8|compound|END_ENTITY	The lack of NF-kappa_B transactivation and PKC_epsilon expression in CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes correlates with negative selection .
1604322	0	NF-kappa_B	0,10	CD4	48,51	NF-kappa B	CD4	4790	920	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|T T|compound|END_ENTITY	NF-kappa_B subunit regulation in nontransformed CD4 + T lymphocytes .
7915519	0	NF-kappa_B	70,80	CD4	31,34	NF-kappa B	CD4	4790	920	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|Signals Signals|acl|transduced transduced|nmod|molecule molecule|compound|END_ENTITY	Signals transduced through the CD4 molecule on T lymphocytes activate NF-kappa_B .
8878524	0	NF-kappa_B	25,35	CD4	53,56	NF-kappa B	CD4	4790	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Inorganic lead activates NF-kappa_B in primary human CD4 + T lymphocytes .
9571986	0	NF-kappa_B	57,67	CD4	85,88	NF-kappa B	CD4	4790	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Hydroquinone , a reactive metabolite of benzene , inhibits NF-kappa_B in primary human CD4 + T lymphocytes .
7905504	0	NF-kappa_B	19,29	CD45	11,15	NF-kappa B	CD45	4790	5788	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of CD45 on NF-kappa_B .
9759866	0	NF-kappa_B	22,32	CD95_ligand	48,59	NF-kappa B	CD95 ligand	18033(Tax:10090)	14103(Tax:10090)	Gene	Gene	sites|amod|START_ENTITY Identification|nmod|sites Identification|nmod|END_ENTITY	Identification of two NF-kappa_B sites in mouse CD95_ligand -LRB- Fas_ligand -RRB- promoter : functional analysis in T cell hybridoma .
18941233	0	NF-kappa_B	78,88	DNA-dependent_activator_of_IFN_regulatory_factors	108,157	NF-kappa B	DNA-dependent activator of IFN regulatory factors	4790	81030	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa_B activation via the DNA-dependent_activator_of_IFN_regulatory_factors .
2406459	0	NF-kappa_B	46,56	EBP1	40,44	NF-kappa B	EBP1	4790	4790	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of enhancer-binding protein EBP1 -LRB- NF-kappa_B -RRB- with the human_immunodeficiency_virus_type_1 enhancer .
9583684	0	NF-kappa_B	64,74	EGFR	96,100	NF-kappa B	EGFR	4790	1956	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
10837465	0	NF-kappa_B	4,14	Fas_ligand	53,63	NF-kappa B	Fas ligand	4790	356	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	The NF-kappa_B signaling pathway is not required for Fas_ligand gene induction but mediates protection from activation-induced cell death .
11135577	0	NF-kappa_B	20,30	GATA3	34,39	NF-kappa B	GATA3	18033(Tax:10090)	14462(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	A critical role for NF-kappa_B in GATA3 expression and TH2 differentiation in allergic_airway_inflammation .
17704804	0	NF-kappa_B	119,129	IEX-1	92,97	NF-kappa B	IEX-1	4790	8870	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	The apoptosis-inducing effect of gastrin on colorectal_cancer cells relates to an increased IEX-1 expression mediating NF-kappa_B inhibition .
10227974	0	NF-kappa_B	22,32	IFN-gamma	50,59	NF-kappa B	IFN-gamma	4790	3458	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	An essential role for NF-kappa_B in IL-18-induced IFN-gamma expression in KG-1 cells .
11278357	1	NF-kappa_B	159,169	IFNgamma	126,134	NF-kappa B	IFNgamma	4790	3458	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IFNgamma inhibits cytoprotective NF-kappa_B through STAT1/IRF -1 pathways .
12167626	0	NF-kappa_B	40,50	IKK_beta	0,8	NF-kappa B	IKK beta	4790	3551	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	IKK_beta is required for Bcl-2-mediated NF-kappa_B activation in ventricular myocytes .
10723136	0	NF-kappa_B	117,127	IKK_gamma	104,113	NF-kappa B	IKK gamma	4790	8517	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Somatic mutagenesis studies of NF-kappa_B signaling in human T cells : evidence for an essential role of IKK_gamma in NF-kappa_B activation by T-cell costimulatory signals and HTLV-I Tax protein .
10723136	0	NF-kappa_B	31,41	IKK_gamma	104,113	NF-kappa B	IKK gamma	4790	8517	Gene	Gene	studies|nmod|START_ENTITY studies|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Somatic mutagenesis studies of NF-kappa_B signaling in human T cells : evidence for an essential role of IKK_gamma in NF-kappa_B activation by T-cell costimulatory signals and HTLV-I Tax protein .
18207244	0	NF-kappa_B	73,83	IKK_gamma	39,48	NF-kappa B	IKK gamma	4790	8517	Gene	Gene	activation|nmod|START_ENTITY block|dobj|activation block|nsubj|Mutations Mutations|nmod|domain domain|nmod|END_ENTITY	Mutations in the zinc finger domain of IKK_gamma block the activation of NF-kappa_B and the induction of IL-2 in stimulated T lymphocytes .
7521369	0	NF-kappa_B	14,24	IL-1	149,153	NF-kappa B	IL-1	4790	3552	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of NF-kappa_B and induction of vascular_cell_adhesion_molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1 .
8021507	0	NF-kappa_B	0,10	IL-1_beta	21,30	NF-kappa B	IL-1 beta	4790	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	NF-kappa_B regulates IL-1_beta transcription through a consensus NF-kappa_B binding site and a nonconsensus CRE-like site .
11120852	0	NF-kappa_B	107,117	IL-6	14,18	NF-kappa B	IL-6	4790	3569	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of IL-6 and IL-8 expression in rheumatoid_arthritis synovial fibroblasts : the dominant role for NF-kappa_B but not C/EBP _ beta or c-Jun .
12960348	0	NF-kappa_B	13,23	IL-6	0,4	NF-kappa B	IL-6	4790	3569	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	IL-6 induces NF-kappa_B activation in the intestinal epithelia .
8797825	0	NF-kappa_B	54,64	I_kappa_B-alpha	28,43	NF-kappa B	I kappa B-alpha	4790	4792	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of I_kappa_B-alpha activates NF-kappa_B without proteolytic degradation of I_kappa_B-alpha .
10582246	0	NF-kappa_B	11,21	I_kappa_B_alpha	82,97	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY Control|nmod|activation induced|nsubj|Control induced|dobj|proteolysis proteolysis|nmod|END_ENTITY	Control of NF-kappa_B transcriptional activation by signal induced proteolysis of I_kappa_B_alpha .
10779782	0	NF-kappa_B	82,92	I_kappa_B_alpha	21,36	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|switch switch|nmod|mechanisms mechanisms|compound|END_ENTITY	A switch in distinct I_kappa_B_alpha degradation mechanisms mediates constitutive NF-kappa_B activation in mature B cells .
10882738	0	NF-kappa_B	40,50	I_kappa_B_alpha	13,28	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	dimers|amod|START_ENTITY binding|nmod|dimers Mechanism|amod|binding Mechanism|nmod|END_ENTITY	Mechanism of I_kappa_B_alpha binding to NF-kappa_B dimers .
11780335	0	NF-kappa_B	15,25	I_kappa_B_alpha	45,60	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	LMP1 activates NF-kappa_B via degradation of I_kappa_B_alpha in nasopharyngeal_carcinoma cells .
12193729	0	NF-kappa_B	14,24	I_kappa_B_alpha	70,85	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activity|amod|START_ENTITY Inhibition|nmod|activity Inhibition|nmod|mutant mutant|nmod|END_ENTITY	Inhibition of NF-kappa_B activity by a membrane-transducing mutant of I_kappa_B_alpha .
12244195	0	NF-kappa_B	0,10	I_kappa_B_alpha	54,69	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|neutrophils neutrophils|nmod|END_ENTITY	NF-kappa_B regulation in human neutrophils by nuclear I_kappa_B_alpha : correlation to apoptosis .
12618762	0	NF-kappa_B	27,37	I_kappa_B_alpha	50,65	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activity|amod|START_ENTITY activity|nmod|M M|compound|END_ENTITY	Inhibition of constitutive NF-kappa_B activity by I_kappa_B_alpha M suppresses tumorigenesis .
12711606	0	NF-kappa_B	28,38	I_kappa_B_alpha	75,90	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Hydrogen_peroxide activates NF-kappa_B through tyrosine phosphorylation of I_kappa_B_alpha and serine phosphorylation of p65 : evidence for the involvement of I_kappa_B_alpha kinase and Syk protein-tyrosine kinase .
12917341	0	NF-kappa_B	46,56	I_kappa_B_alpha	151,166	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY associated|nsubjpass|activation associated|nmod|reappearance reappearance|nmod|END_ENTITY	Potentiation of tumor necrosis factor-induced NF-kappa_B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I_kappa_B_alpha .
12963487	0	NF-kappa_B	18,28	I_kappa_B_alpha	84,99	NF-kappa B	I kappa B alpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|cleavage cleavage|nmod|END_ENTITY	Genistein reduces NF-kappa_B in T_lymphoma cells via a caspase-mediated cleavage of I_kappa_B_alpha .
15265936	0	NF-kappa_B	65,75	I_kappa_B_alpha	123,138	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY abrogates|dobj|activation abrogates|nmod|inhibition inhibition|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Cyclooxygenase _ -LRB- COX -RRB- -2 inhibitor celecoxib abrogates TNF-induced NF-kappa_B activation through inhibition of activation of I_kappa_B_alpha kinase and Akt in human non-small_cell_lung_carcinoma : correlation with suppression of COX-2 synthesis .
15596146	0	NF-kappa_B	14,24	I_kappa_B_alpha	53,68	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	START_ENTITY|nmod|form form|nmod|END_ENTITY	Inhibition of NF-kappa_B by a cell permeable form of I_kappa_B_alpha induces apoptosis in eosinophils .
15950952	0	NF-kappa_B	25,35	I_kappa_B_alpha	143,158	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY prevents|dobj|activation prevents|parataxis|stabilizes stabilizes|dobj|END_ENTITY	HDAC inhibition prevents NF-kappa_B activation by suppressing proteasome activity : down-regulation of proteasome subunit expression stabilizes I_kappa_B_alpha .
16081774	0	NF-kappa_B	57,67	I_kappa_B_alpha	94,109	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	independent|amod|START_ENTITY independent|nmod|degradation degradation|compound|END_ENTITY	A helminth glycan induces APC maturation via alternative NF-kappa_B activation independent of I_kappa_B_alpha degradation .
7479848	0	NF-kappa_B	64,74	I_kappa_B_alpha	22,37	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	inhibitor|amod|START_ENTITY marks|dobj|inhibitor marks|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Stimulation-dependent I_kappa_B_alpha phosphorylation marks the NF-kappa_B inhibitor for degradation via the ubiquitin-proteasome pathway .
7629157	0	NF-kappa_B	14,24	I_kappa_B_alpha	83,98	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	Activation|nmod|START_ENTITY involves|nsubj|Activation involves|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Activation of NF-kappa_B by phosphatase inhibitors involves the phosphorylation of I_kappa_B_alpha at phosphatase 2A-sensitive sites .
7675460	0	NF-kappa_B	14,24	I_kappa_B_alpha	60,75	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	Rel|compound|START_ENTITY Activation|nmod|Rel involves|nsubj|Activation involves|dobj|degradation degradation|nmod|END_ENTITY	Activation of NF-kappa_B / Rel by Tax involves degradation of I_kappa_B_alpha and is blocked by a proteasome inhibitor .
7739549	0	NF-kappa_B	133,143	I_kappa_B_alpha	50,65	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activities|nmod|START_ENTITY regulates|dobj|activities regulates|nsubj|expression expression|nmod|END_ENTITY	Inducible nuclear expression of newly synthesized I_kappa_B_alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa_B .
7739562	0	NF-kappa_B	81,91	I_kappa_B_alpha	40,55	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY Coupling|nmod|activation Coupling|nmod|domain domain|nmod|END_ENTITY	Coupling of a signal response domain in I_kappa_B_alpha to multiple pathways for NF-kappa_B activation .
7775482	0	NF-kappa_B	86,96	I_kappa_B_alpha	31,46	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	inhibition|nmod|START_ENTITY mediates|dobj|inhibition mediates|nsubj|Induction Induction|nmod|END_ENTITY	Induction and stabilization of I_kappa_B_alpha by nitric_oxide mediates inhibition of NF-kappa_B .
7884865	0	NF-kappa_B	16,26	I_kappa_B_alpha	64,79	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	LMP-1 activates NF-kappa_B by targeting the inhibitory molecule I_kappa_B_alpha .
7891711	0	NF-kappa_B	69,79	I_kappa_B_alpha	23,38	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	p65|amod|START_ENTITY organization|nmod|p65 organization|nmod|END_ENTITY	Domain organization of I_kappa_B_alpha and sites of interaction with NF-kappa_B p65 .
7925301	0	NF-kappa_B	121,131	I_kappa_B_alpha	59,74	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activity|amod|START_ENTITY pools|nmod|activity determine|dobj|pools determine|nsubj|interactions interactions|nmod|complexes complexes|nmod|END_ENTITY	Differential interactions of Rel-NF-kappa_B complexes with I_kappa_B_alpha determine pools of constitutive and inducible NF-kappa_B activity .
7935451	0	NF-kappa_B	53,63	I_kappa_B_alpha	112,127	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|nmod|START_ENTITY mediated|nsubj|activation mediated|parataxis|involves involves|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
7991551	0	NF-kappa_B	89,99	I_kappa_B_alpha	29,44	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	dissociation|nmod|START_ENTITY sufficient|nmod|dissociation sufficient|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Inducible phosphorylation of I_kappa_B_alpha is not sufficient for its dissociation from NF-kappa_B and is inhibited by protease inhibitors .
8096091	0	NF-kappa_B	0,10	I_kappa_B_alpha	44,59	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	NF-kappa_B controls expression of inhibitor I_kappa_B_alpha : evidence for an inducible autoregulatory pathway .
8164680	0	NF-kappa_B	69,79	I_kappa_B_alpha	9,24	NF-kappa B	I kappa B alpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY responsible|nmod|activity responsible|nsubj|degradation degradation|compound|END_ENTITY	Enhanced I_kappa_B_alpha degradation is responsible for constitutive NF-kappa_B activity in mature murine B-cell lines .
8223478	0	NF-kappa_B	19,29	I_kappa_B_alpha	44,59	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	control|nmod|START_ENTITY activation|nsubj|control activation|nmod|END_ENTITY	In vivo control of NF-kappa_B activation by I_kappa_B_alpha .
8255759	0	NF-kappa_B	149,159	I_kappa_B_alpha	33,48	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|nmod|START_ENTITY steps|nmod|activation steps|nsubj|degradation degradation|nmod|MAD3 MAD3|appos|END_ENTITY	Proteolytic degradation of MAD3 -LRB- I_kappa_B_alpha -RRB- and enhanced processing of the NF-kappa_B precursor p105 are obligatory steps in the activation of NF-kappa_B .
8497253	0	NF-kappa_B	109,119	I_kappa_B_alpha	76,91	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|amod|START_ENTITY mechanism|nmod|activation necrosis|parataxis|mechanism necrosis|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I_kappa_B_alpha : a mechanism for NF-kappa_B activation .
8642242	0	NF-kappa_B	137,147	I_kappa_B_alpha	79,94	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	Inhibition of endothelial cell activation by adenovirus-mediated expression of I_kappa_B_alpha , an inhibitor of the transcription factor NF-kappa_B .
8758892	0	NF-kappa_B	20,30	I_kappa_B_alpha	105,120	NF-kappa B	I kappa B alpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|inducing inducing|dobj|apoptosis apoptosis|dep|activation activation|nmod|END_ENTITY	TGF_beta_1 inhibits NF-kappa_B / Rel activity inducing apoptosis of B cells : transcriptional activation of I_kappa_B_alpha .
9057089	0	NF-kappa_B	69,79	I_kappa_B_alpha	24,39	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	transport|nmod|START_ENTITY promotes|dobj|transport promotes|nsubj|localization localization|nmod|END_ENTITY	Nuclear localization of I_kappa_B_alpha promotes active transport of NF-kappa_B from the nucleus to the cytoplasm .
9338014	0	NF-kappa_B	0,10	I_kappa_B_alpha	155,170	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	START_ENTITY|dep|suppression suppression|nmod|responses responses|nmod|cells cells|nmod|transfer transfer|nmod|cDNA cDNA|compound|END_ENTITY	NF-kappa_B as a target for anti-inflammatory gene therapy : suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of I_kappa_B_alpha cDNA .
9442373	0	NF-kappa_B	14,24	I_kappa_B_alpha	37,52	NF-kappa B	I kappa B alpha	4790	4792	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of NF-kappa_B activity by I_kappa_B_alpha and I_kappa_B_beta stability .
8816457	0	NF-kappa_B	87,97	I_kappa_B_beta	44,58	NF-kappa B	I kappa B beta	4790	4793	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of unphosphorylated , newly synthesized I_kappa_B_beta in persistent activation of NF-kappa_B .
9442374	0	NF-kappa_B	11,21	I_kappa_B_beta	38,52	NF-kappa B	I kappa B beta	4790	4793	Gene	Gene	activity|amod|START_ENTITY Control|nmod|activity Control|nmod|inhibitor inhibitor|compound|END_ENTITY	Control of NF-kappa_B activity by the I_kappa_B_beta inhibitor .
11160335	0	NF-kappa_B	0,10	I_kappa_B_kinase-2	25,43	NF-kappa B	I kappa B kinase-2	4790	3551	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	NF-kappa_B regulation by I_kappa_B_kinase-2 in rheumatoid_arthritis synoviocytes .
10934190	0	NF-kappa_B	29,39	I_kappa_b_alpha	64,79	NF-kappa B	I kappa b alpha	4790	4792	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|homologue homologue|nmod|END_ENTITY	Mechanism of inactivation of NF-kappa_B by a viral homologue of I_kappa_b_alpha .
10969074	0	NF-kappa_B	31,41	IkappaBalpha	0,12	NF-kappa B	IkappaBalpha	4790	4792	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	IkappaBalpha and IkappaBalpha / NF-kappa_B complexes are retained in the cytoplasm through interaction with a novel partner , RasGAP SH3-binding protein 2 .
1386364	0	NF-kappa_B	22,32	Interleukin_1	0,13	NF-kappa B	Interleukin 1	18033(Tax:10090)	111343(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin_1 induces NF-kappa_B through its type I but not its type II receptor in lymphocytes .
7556623	0	NF-kappa_B	24,34	JAK2	78,82	NF-kappa B	JAK2	4790	3717	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Herbimycin_A suppresses NF-kappa_B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric_oxide synthase in C6 glioma cells .
12324457	0	NF-kappa_B	40,50	Ku70	14,18	NF-kappa B	Ku70	4790	2547	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Expression of Ku70 and Ku80 mediated by NF-kappa_B and cyclooxygenase-2 is related to proliferation of human gastric_cancer cells .
11780335	0	NF-kappa_B	15,25	LMP1	0,4	NF-kappa B	LMP1	4790	9260	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	LMP1 activates NF-kappa_B via degradation of I_kappa_B_alpha in nasopharyngeal_carcinoma cells .
9583684	0	NF-kappa_B	64,74	LMP1	20,24	NF-kappa B	LMP1	4790	9260	Gene	Gene	activation|nmod|START_ENTITY confers|dobj|activation confers|nsubj|protein protein|compound|END_ENTITY	The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa_B and induction of the EGFR in epithelial cells .
8505309	0	NF-kappa_B	87,97	MAD3	46,50	NF-kappa B	MAD3	4790	4792	Gene	Gene	proteins|compound|START_ENTITY phosphorylation|nmod|proteins phosphorylation|nmod|END_ENTITY	Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa_B proteins in human monocytic THP-1 cells .
10891398	0	NF-kappa_B	47,57	MCP-1	69,74	NF-kappa B	MCP-1	4790	6347	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Macrophages stimulated with IFN-gamma activate NF-kappa_B and induce MCP-1 gene expression in primary human endothelial cells .
15494508	0	NF-kappa_B	0,10	MHC_class_I-related_chain_A_gene	39,71	NF-kappa B	MHC class I-related chain A gene	4790	100507436	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	NF-kappa_B regulates expression of the MHC_class_I-related_chain_A_gene in activated T lymphocytes .
24984269	0	NF-kappa_B	75,85	MMP-3	104,109	NF-kappa B	MMP-3	4790	4314	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	CCL20/CCR6 promotes the invasion and migration of thyroid_cancer cells via NF-kappa_B signaling-induced MMP-3 production .
7476933	0	NF-kappa_B	87,97	MnSOD	47,52	NF-kappa B	MnSOD	4790	6648	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	Thiol modulation of TNF_alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa_B .
7491977	0	NF-kappa_B	14,24	MnSOD	42,47	NF-kappa B	MnSOD	4790	6648	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|compound|END_ENTITY	Activation of NF-kappa_B and elevation of MnSOD gene expression by thiol reducing agents in lung_adenocarcinoma -LRB- A549 -RRB- cells .
11773638	0	NF-kappa_B	41,51	Mullerian-inhibiting_substance	0,30	NF-kappa B	Mullerian-inhibiting substance	4790	268	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Mullerian-inhibiting_substance regulates NF-kappa_B signaling in the prostate in vitro and in vivo .
15128775	0	NF-kappa_B	60,70	NF-kappa_B	86,96	NF-kappa B	NF-kappa B	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- inhibits receptor activator of NF-kappa_B ligand-induced NF-kappa_B activation in osteoclast precursors and suppresses osteoclastogenesis .
15128775	0	NF-kappa_B	86,96	NF-kappa_B	60,70	NF-kappa B	NF-kappa B	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- inhibits receptor activator of NF-kappa_B ligand-induced NF-kappa_B activation in osteoclast precursors and suppresses osteoclastogenesis .
8164652	0	NF-kappa_B	12,22	NF-kappa_B	166,176	NF-kappa B	NF-kappa B	4790	4790	Gene	Gene	Function|nmod|START_ENTITY Function|parataxis|dependent dependent|nmod|cell-specific cell-specific|nmod|subunits subunits|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	NF-kappa_B	166,176	NF-kappa_B	12,22	NF-kappa B	NF-kappa B	4790	4790	Gene	Gene	subunits|compound|START_ENTITY cell-specific|nmod|subunits dependent|nmod|cell-specific Function|parataxis|dependent Function|nmod|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
11884470	0	NF-kappa_B	61,71	NURR1	38,43	NF-kappa B	NURR1	4790	4929	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Activation of nuclear orphan receptor NURR1 transcription by NF-kappa_B and cyclic_adenosine_5 ' - monophosphate response element-binding protein in rheumatoid_arthritis synovial tissue .
12775719	0	NF-kappa_B	24,34	Nod1	49,53	NF-kappa B	Nod1	4790	10392	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	CARD6 is a modulator of NF-kappa_B activation by Nod1 - and Cardiak-mediated pathways .
11418662	0	NF-kappa_B	23,33	Notch-1	6,13	NF-kappa B	Notch-1	4790	4851	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Human Notch-1 inhibits NF-kappa_B activity in the nucleus through a direct interaction involving a novel domain .
14527959	0	NF-kappa_B	66,76	PKC_delta	56,65	NF-kappa B	PKC delta	4790	5580	Gene	Gene	Induction|parataxis|START_ENTITY Induction|nmod|END_ENTITY	Induction of cIAP-2 in human colon_cancer cells through PKC_delta / NF-kappa_B .
10723127	0	NF-kappa_B	14,24	PKR	64,67	NF-kappa B	PKR	4790	5610	Gene	Gene	Activation|nmod|START_ENTITY involves|advcl|Activation involves|nsubj|END_ENTITY	Activation of NF-kappa_B by the dsRNA-dependent protein kinase , PKR involves the I kappa B kinase complex .
11342638	0	NF-kappa_B	63,73	PKR	29,32	NF-kappa B	PKR	4790	5610	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	RNA-dependent protein kinase PKR is required for activation of NF-kappa_B by IFN-gamma in a STAT1-independent pathway .
15121867	0	NF-kappa_B	35,45	PKR	26,29	NF-kappa B	PKR	4790	5610	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	TRAF family proteins link PKR with NF-kappa_B activation .
14729949	0	NF-kappa_B	34,44	PTEN	15,19	NF-kappa B	PTEN	4790	5728	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Suppression of PTEN expression by NF-kappa_B prevents apoptosis .
15739190	0	NF-kappa_B	110,120	Pigment_epithelium-derived_factor	0,33	NF-kappa B	Pigment epithelium-derived factor	4790	57104	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Pigment_epithelium-derived_factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-kappa_B and CREB .
8523529	0	NF-kappa_B	31,41	Protein_kinase_C-zeta	0,21	NF-kappa B	Protein kinase C-zeta	4790	5590	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Protein_kinase_C-zeta mediates NF-kappa_B activation in human_immunodeficiency_virus-infected monocytes .
15064760	0	NF-kappa_B	62,72	RIP1	0,4	NF-kappa B	RIP1	18033(Tax:10090)	19766(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediator|nmod|activation mediator|nsubj|END_ENTITY	RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa_B activation .
12446564	0	NF-kappa_B	67,77	RIP4	0,4	NF-kappa B	RIP4	4790	54101	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	RIP4 -LRB- DIK/PKK -RRB- , a novel member of the RIP kinase family , activates NF-kappa_B and is processed during apoptosis .
10079054	0	NF-kappa_B	99,109	Rel	110,113	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Acetylaminofluorene inhibits nitric_oxide production in LPS-stimulated RAW 264.7 cells by blocking NF-kappa_B / Rel activation .
10508271	0	NF-kappa_B	71,81	Rel	82,85	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	dependence|nmod|START_ENTITY differences|nmod|dependence differences|parataxis|signaling signaling|nsubj|END_ENTITY	Lineage-specific differences among CD8 + T cells in their dependence of NF-kappa_B / Rel signaling .
10744656	0	NF-kappa_B	196,206	Rel	207,210	NF-kappa B	Rel	4790	5966	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Stimulation of Fc gamma R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I_kappa_B-alpha degradation and formation of p50/p65 NF-kappa_B / Rel complexes .
10918492	0	NF-kappa_B	94,104	Rel	105,108	NF-kappa B	Rel	4790	5966	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|dep|END_ENTITY	Enhancement of cytosine_arabinoside-induced apoptosis in human myeloblastic_leukemia cells by NF-kappa_B / Rel - specific decoy oligodeoxynucleotides .
10918492	3	NF-kappa_B	491,501	Rel	502,505	NF-kappa B	Rel	4790	5966	Gene	Gene	sequence|amod|START_ENTITY sequence|dep|END_ENTITY	To this end we used a phosphorothioate double-stranded decoy oligodeoxynucleotide -LRB- ODN -RRB- carrying the NF-kappa_B / Rel - consensus sequence .
11160275	0	NF-kappa_B	0,10	Rel	11,14	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|lymphoid lymphoid|nsubj|participation participation|compound|END_ENTITY	NF-kappa_B / Rel participation in the lymphokine-dependent proliferation of T lymphoid cells .
11714807	0	NF-kappa_B	8,18	Rel	19,22	NF-kappa B	Rel	4790	5966	Gene	Gene	START_ENTITY|parataxis|cooperates cooperates|nsubj|site site|compound|END_ENTITY	A novel NF-kappa_B / Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor .
11912207	0	NF-kappa_B	19,29	Rel	30,33	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	Opposing|nmod|START_ENTITY p65|dep|Opposing p65|amod|END_ENTITY	Opposing roles for NF-kappa_B / Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta .
14634280	0	NF-kappa_B	70,80	Rel	81,84	NF-kappa B	Rel	4790	5966	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Regulation of cell survival in CD95-induced T cell apoptosis : role of NF-kappa_B / Rel transcription factors .
7479915	0	NF-kappa_B	16,26	Rel	27,30	NF-kappa B	Rel	4790	5966	Gene	Gene	Coexpression|nmod|START_ENTITY Coexpression|dep|factors factors|compound|END_ENTITY	Coexpression of NF-kappa_B / Rel and Sp1 transcription factors in human_immunodeficiency_virus_1-induced , dendritic_cell-T-cell_syncytia .
7508926	0	NF-kappa_B	29,39	Rel	40,43	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of transcription factor NF-kappa_B / Rel in induction of nitric_oxide synthase .
7537042	0	NF-kappa_B	97,107	Rel	108,111	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Transcriptional inhibition of the inducible nitric_oxide synthase gene by competitive binding of NF-kappa_B / Rel proteins .
7559449	0	NF-kappa_B	93,103	Rel	104,107	NF-kappa B	Rel	4790	5966	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-kappa_B / Rel family .
7594464	0	NF-kappa_B	100,110	Rel	111,114	NF-kappa B	Rel	4790	5966	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|parataxis|END_ENTITY	Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa_B / Rel protein complexes .
7692309	0	NF-kappa_B	9,19	Rel	20,23	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|responsible responsible|nsubj|factors factors|compound|END_ENTITY	Distinct NF-kappa_B / Rel transcription factors are responsible for tissue-specific and inducible gene activation .
7769726	0	NF-kappa_B	85,95	Rel	96,99	NF-kappa B	Rel	4790	5966	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa_B / Rel family proteins .
7926758	0	NF-kappa_B	47,57	Rel	58,61	NF-kappa B	Rel	4790	5966	Gene	Gene	factors|nummod|START_ENTITY factors|compound|END_ENTITY	The v-abl tyrosine kinase negatively regulates NF-kappa_B / Rel factors and blocks kappa gene transcription in pre-B lymphocytes .
7935451	0	NF-kappa_B	53,63	Rel	64,67	NF-kappa B	Rel	4790	5966	Gene	Gene	activation|nmod|START_ENTITY mediated|nsubj|activation mediated|parataxis|involves involves|nsubj|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
7941339	0	NF-kappa_B	52,62	Rel	63,66	NF-kappa B	Rel	4790	5966	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Subcellular redistribution of HTLV-1 Tax protein by NF-kappa_B / Rel transcription factors .
7982981	0	NF-kappa_B	49,59	Rel	60,63	NF-kappa B	Rel	4790	5966	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	In vitro study of functional involvement of Sp1 , NF-kappa_B / Rel , and AP1 in phorbol_12-myristate_13-acetate-mediated HIV-1 long terminal repeat activation .
8035813	0	NF-kappa_B	24,34	Rel	35,38	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|dep|proteins proteins|compound|END_ENTITY	Sequential induction of NF-kappa_B / Rel family proteins during B-cell terminal differentiation .
8152286	0	NF-kappa_B	19,29	Rel	30,33	NF-kappa B	Rel	4790	5966	Gene	Gene	induction|nmod|START_ENTITY induction|dep|proteins proteins|compound|END_ENTITY	Virus induction of NF-kappa_B / Rel proteins and type I interferon gene expression in myelomonoblastic cells .
8152812	0	NF-kappa_B	23,33	Rel	34,37	NF-kappa B	Rel	4790	5966	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|necrosis necrosis|nsubj|complexes complexes|compound|END_ENTITY	Activation of multiple NF-kappa_B / Rel DNA-binding complexes by tumor necrosis factor .
8164652	0	NF-kappa_B	12,22	Rel	177,180	NF-kappa B	Rel	4790	5966	Gene	Gene	Function|nmod|START_ENTITY Function|parataxis|dependent dependent|nmod|cell-specific cell-specific|nmod|subunits subunits|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	NF-kappa_B	12,22	Rel	23,26	NF-kappa B	Rel	4790	5966	Gene	Gene	Function|nmod|START_ENTITY Function|parataxis|dependent dependent|nsubj|sites sites|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	NF-kappa_B	166,176	Rel	177,180	NF-kappa B	Rel	4790	5966	Gene	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	NF-kappa_B	166,176	Rel	23,26	NF-kappa B	Rel	4790	5966	Gene	Gene	subunits|compound|START_ENTITY cell-specific|nmod|subunits dependent|nmod|cell-specific dependent|nsubj|sites sites|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8321203	0	NF-kappa_B	45,55	Rel	84,87	NF-kappa B	Rel	4790	5966	Gene	Gene	members|compound|START_ENTITY associations|nmod|members associations|dep|interaction interaction|compound|END_ENTITY	Functional and physical associations between NF-kappa_B and C/EBP family members : a Rel domain-bZIP interaction .
8530134	0	NF-kappa_B	25,35	Rel	36,39	NF-kappa B	Rel	4790	5966	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Multi-step activation of NF-kappa_B / Rel transcription factors .
8758892	0	NF-kappa_B	20,30	Rel	31,34	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|inducing inducing|nsubj|activity activity|compound|END_ENTITY	TGF_beta_1 inhibits NF-kappa_B / Rel activity inducing apoptosis of B cells : transcriptional activation of I_kappa_B_alpha .
8887449	0	NF-kappa_B	62,72	Rel	73,76	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|activity activity|compound|END_ENTITY	Effects of vomitoxin -LRB- deoxynivalenol -RRB- on transcription factor NF-kappa_B / Rel binding activity in murine EL-4_thymoma and primary CD4 + T cells .
8899295	0	NF-kappa_B	45,55	Rel	56,59	NF-kappa B	Rel	4790	5966	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|dep|proteins proteins|compound|END_ENTITY	Biological and biochemical inhibitors of the NF-kappa_B / Rel proteins and cytokine synthesis .
9679644	0	NF-kappa_B	14,24	Rel	25,28	NF-kappa B	Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Inhibition of NF-kappa_B / Rel nuclear translocation by dexamethasone : mechanism for the inhibition of iNOS gene expression .
10496024	0	NF-kappa_B	22,32	RelA	33,37	NF-kappa B	RelA	4790	5970	Gene	Gene	START_ENTITY|parataxis|activated activated|nsubj|END_ENTITY	-LSB- Transcription factor NF-kappa_B / RelA are constitutively activated and localized in the cell nuclei of E1A + cHa-Ras transformants -RSB- .
7603567	0	NF-kappa_B	81,91	RelA	63,67	NF-kappa B	RelA	18033(Tax:10090)	19697(Tax:10090)	Gene	Gene	component|nmod|START_ENTITY component|compound|END_ENTITY	Embryonic_lethality_and_liver_degeneration in mice lacking the RelA component of NF-kappa_B .
8108414	0	NF-kappa_B	22,32	RelA	48,52	NF-kappa B	RelA	4790	5970	Gene	Gene	Autoregulation|nmod|START_ENTITY transactivator|nsubj|Autoregulation transactivator|dobj|p65 p65|compound|END_ENTITY	Autoregulation of the NF-kappa_B transactivator RelA -LRB- p65 -RRB- by multiple cytoplasmic inhibitors containing ankyrin motifs .
11567019	0	NF-kappa_B	15,25	SNIP1	0,5	NF-kappa B	SNIP1	4790	79753	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	SNIP1 inhibits NF-kappa_B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators .
9277450	0	NF-kappa_B	31,41	Surfactant_protein_A	0,20	NF-kappa B	Surfactant protein A	4790	653509	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Surfactant_protein_A activates NF-kappa_B in the THP-1 monocytic cell line .
11390505	0	NF-kappa_B	31,41	Surfactant_protein_D	0,20	NF-kappa B	Surfactant protein D	18033(Tax:10090)	20390(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Surfactant_protein_D regulates NF-kappa_B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways .
19124728	0	NF-kappa_B	34,44	TLR2	57,61	NF-kappa B	TLR2	4790	7097	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	The EBV-encoded dUTPase activates NF-kappa_B through the TLR2 and MyD88-dependent signaling pathway .
10640779	0	NF-kappa_B	0,10	TNF-alpha	21,30	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|amod|END_ENTITY	NF-kappa_B modulates TNF-alpha production by alveolar macrophages in asymptomatic HIV-seropositive individuals .
10754326	0	NF-kappa_B	56,66	TNF-alpha	0,9	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	regulation|nmod|START_ENTITY macrophages|dep|regulation expression|nmod|macrophages expression|amod|END_ENTITY	TNF-alpha gene expression in macrophages : regulation by NF-kappa_B is independent of c-Jun or C/EBP _ beta .
10759767	0	NF-kappa_B	40,50	TNF-alpha	98,107	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	mobilization|amod|START_ENTITY salts|nmod|mobilization Effects|nmod|salts Effects|appos|END_ENTITY	Effects of anti-rheumatic gold salts on NF-kappa_B mobilization and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- - induced neutrophil-dependent cytotoxicity for human endothelial cells .
11368927	0	NF-kappa_B	55,65	TNF-alpha	80,89	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY prevents|dobj|activation prevents|nmod|END_ENTITY	Soy isoflavone supplementation in healthy men prevents NF-kappa_B activation by TNF-alpha in blood lymphocytes .
11420928	0	NF-kappa_B	20,30	TNF-alpha	0,9	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	TNF-alpha dependent NF-kappa_B activation in cultured canine keratinocytes is partly mediated by reactive oxygen species .
11489936	0	NF-kappa_B	39,49	TNF-alpha	0,9	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY SDF-1|dobj|activation SDF-1|nsubj|mediates mediates|amod|END_ENTITY	TNF-alpha mediates SDF-1 alpha-induced NF-kappa_B activation and cytotoxic effects in primary astrocytes .
12061837	0	NF-kappa_B	65,75	TNF-alpha	12,21	NF-kappa B	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	signaling|dep|START_ENTITY evidence|dep|signaling regulation|nmod|evidence mediated|dobj|regulation mediated|nsubj|END_ENTITY	Recombinant TNF-alpha mediated regulation of the I_kappa_B-alpha / NF-kappa_B signaling pathway : evidence for the enhancement of pro- and anti-inflammatory cytokines in alveolar epithelial cells .
12388359	0	NF-kappa_B	0,10	TNF-alpha	82,91	NF-kappa B	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY _|nsubj|inhibition _|ccomp|modulates modulates|dobj|transcription transcription|amod|END_ENTITY	NF-kappa_B inhibition by omega _ -3 _ fatty_acids modulates LPS-stimulated macrophage TNF-alpha transcription .
12508545	0	NF-kappa_B	11,21	TNF-alpha	90,99	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	pathway|amod|START_ENTITY Effect|nmod|pathway induced|nsubj|Effect induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of NF-kappa_B pathway on apoptosis of hepatic_carcinoma cell line-7721 induced by TNF-alpha -RSB- .
12684057	0	NF-kappa_B	81,91	TNF-alpha	0,9	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY cardiomyocytes|nmod|activation induce|nmod|cardiomyocytes induce|nsubj|END_ENTITY	TNF-alpha and H2O2 induce IL-18 and IL-18R_beta expression in cardiomyocytes via NF-kappa_B activation .
14530313	0	NF-kappa_B	86,96	TNF-alpha	22,31	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	activation|compound|START_ENTITY effects|dep|activation effects|nmod|END_ENTITY	Functional effects of TNF-alpha on a human follicular dendritic cell line : persistent NF-kappa_B activation and sensitization for Fas-mediated apoptosis .
15557189	0	NF-kappa_B	71,81	TNF-alpha	22,31	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	involvement|nmod|START_ENTITY mechanism|dep|involvement mechanism|nmod|regulation regulation|amod|END_ENTITY	A novel mechanism for TNF-alpha regulation by p38 MAPK : involvement of NF-kappa_B with implications for therapy in rheumatoid_arthritis .
15694363	0	NF-kappa_B	89,99	TNF-alpha	0,9	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	pathway|compound|START_ENTITY fibroblasts|nmod|pathway modulates|nmod|fibroblasts modulates|nsubj|END_ENTITY	TNF-alpha modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-kappa_B signalling pathway .
18182252	0	NF-kappa_B	45,55	TNF-alpha	27,36	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY induced|dobj|activation END_ENTITY|acl|induced	Alpha-lipoic_acid inhibits TNF-alpha induced NF-kappa_B activation through blocking of MEKK1-MKK4-IKK signaling cascades .
7583354	0	NF-kappa_B	21,31	TNF-alpha	48,57	NF-kappa B	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	migration|nmod|START_ENTITY correlates|nsubj|migration correlates|nmod|accumulation accumulation|amod|END_ENTITY	Nuclear migration of NF-kappa_B correlates with TNF-alpha mRNA accumulation .
7608567	0	NF-kappa_B	109,119	TNF-alpha	40,49	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	role|nmod|START_ENTITY activation|dep|role activation|nmod|promoter promoter|amod|END_ENTITY	Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells : role of NF-kappa_B .
8490102	0	NF-kappa_B	48,58	TNF-alpha	117,126	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	mRNA|amod|START_ENTITY affecting|dobj|mRNA affecting|nmod|END_ENTITY	One and two-level regulation patterns affecting NF-kappa_B mRNA and nuclear NF-kappa_B activity after treatment with TNF-alpha , IFN-gamma and IL-4 .
8873967	0	NF-kappa_B	42,52	TNF-alpha	106,115	NF-kappa B	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY mediator|nsubj|translocation mediator|nmod|response response|nmod|END_ENTITY	Ceramide-induced nuclear translocation of NF-kappa_B is a potential mediator of the apoptotic response to TNF-alpha in murine clonal_osteoblasts .
9035283	0	NF-kappa_B	14,24	TNF-alpha	89,98	NF-kappa B	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY Inhibition|nmod|activation correlates|nsubj|Inhibition correlates|nmod|suppression suppression|nmod|transcription transcription|amod|END_ENTITY	Inhibition of NF-kappa_B activation by dimethyl_sulfoxide correlates with suppression of TNF-alpha formation , reduced ICAM-1 gene transcription , and protection against endotoxin-induced liver_injury .
9415036	0	NF-kappa_B	102,112	TNF-alpha	48,57	NF-kappa B	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY synthesis|nmod|presence synthesis|amod|END_ENTITY	Tosylphenylalanine_chloromethyl_ketone inhibits TNF-alpha mRNA synthesis in the presence of activated NF-kappa_B in RAW 264.7 macrophages .
9486215	0	NF-kappa_B	88,98	TNF-alpha	45,54	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of surfactant proteins A and B by TNF-alpha and phorbol_ester independent of NF-kappa_B .
9521860	0	NF-kappa_B	128,138	TNF-alpha	0,9	NF-kappa B	TNF-alpha	4790	7124	Gene	Gene	receptors|nmod|START_ENTITY interaction|nmod|receptors evidence|nmod|interaction expression|dep|evidence expression|amod|END_ENTITY	TNF-alpha and 9-cis-retinoic_acid synergistically induce ICAM-1 expression : evidence for interaction of retinoid receptors with NF-kappa_B .
9875227	0	NF-kappa_B	121,131	TNF-alpha	144,153	NF-kappa B	TNF-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	subunits|amod|START_ENTITY expression|nmod|subunits regulation|nmod|expression regulation|dep|END_ENTITY	Glutathione downregulates the phosphorylation of I kappa B : autoloop regulation of the NF-kappa_B-mediated expression of NF-kappa_B subunits by TNF-alpha in mouse vascular endothelial cells .
19625651	0	NF-kappa_B	70,80	TREM-2	145,151	NF-kappa B	TREM-2	4790	54209	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|inhibiting inhibiting|dobj|expression expression|compound|END_ENTITY	IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa_B signaling during human osteoclast differentiation by inhibiting TREM-2 expression .
11160322	0	NF-kappa_B	93,103	Tax	39,42	NF-kappa B	Tax	4790	6900	Gene	Gene	site|amod|START_ENTITY activates|nmod|site activates|nsubj|END_ENTITY	Human_T_cell_lymphotropic_virus_type_I Tax activates IL-15R_alpha gene expression through an NF-kappa_B site .
8642682	0	NF-kappa_B	58,68	Tax1	39,43	NF-kappa B	Tax1	4790	6900	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Human_T-cell_lymphotropic_virus_type_1 Tax1 activation of NF-kappa_B : involvement of the protein_kinase_C pathway .
1508666	0	NF-kappa_B	50,60	Thioredoxin	0,11	NF-kappa B	Thioredoxin	4790	7295	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Thioredoxin regulates the DNA binding activity of NF-kappa_B by reduction of a disulphide bond involving cysteine 62 .
15940673	0	NF-kappa_B	64,74	Toll-like_receptor_3_and_4	123,149	NF-kappa B	Toll-like receptor 3 and 4	4790	7098;7099	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa_B activation and IFN-beta synthesis downstream of Toll-like_receptor_3_and_4 .
10823840	0	NF-kappa_B	42,52	Tumor_necrosis_factor-alpha	0,27	NF-kappa B	Tumor necrosis factor-alpha	4790	7124	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Tumor_necrosis_factor-alpha activation of NF-kappa_B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel .
11087727	0	NF-kappa_B	48,58	Tumor_necrosis_factor-alpha	0,27	NF-kappa B	Tumor necrosis factor-alpha	4790	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces distinctive NF-kappa_B signaling within human dermal fibroblasts .
1751774	0	NF-kappa_B	104,114	Tumor_necrosis_factor-alpha	0,27	NF-kappa B	Tumor necrosis factor-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	activators|nmod|START_ENTITY activators|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin_1 , and phorbol_myristate_acetate are independent activators of NF-kappa_B which differentially activate T cells .
8413329	0	NF-kappa_B	107,117	Tumor_necrosis_factor_alpha	0,27	NF-kappa B	Tumor necrosis factor alpha	4790	7124	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha mediates a T cell receptor-independent induction of the gene regulatory factor NF-kappa_B in T lymphocytes .
24286619	0	NF-kappa_B	61,71	USP24	36,41	NF-kappa B	USP24	4790	23358	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of human USP24 gene expression by NF-kappa_B .
10820282	0	NF-kappa_B	0,10	VCAM-1	21,27	NF-kappa B	VCAM-1	18033(Tax:10090)	22329(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	NF-kappa_B regulates VCAM-1 expression on fibroblast-like synoviocytes .
7536741	0	NF-kappa_B	69,79	VCAM-1	42,48	NF-kappa B	VCAM-1	4790	7412	Gene	Gene	motif|amod|START_ENTITY Cell|nmod|motif Cell|dobj|transactivation transactivation|nmod|promoter promoter|compound|END_ENTITY	Cell type-specific transactivation of the VCAM-1 promoter through an NF-kappa_B enhancer motif .
8543010	0	NF-kappa_B	104,114	VCAM-1	33,39	NF-kappa B	VCAM-1	18033(Tax:10090)	22329(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY effect|dep|involvement effect|nmod|ouabain ouabain|nmod|expression expression|compound|END_ENTITY	Stimulatory effect of ouabain on VCAM-1 and iNOS expression in murine endothelial cells : involvement of NF-kappa_B .
11758217	0	NF-kappa_B	15,25	angiotensin_II	107,121	NF-kappa B	angiotensin II	4790	183	Gene	Gene	Activation|nmod|START_ENTITY transcription|nsubj|Activation transcription|nmod|END_ENTITY	-LSB- Activation of NF-kappa_B and its effect on induction of platelet-derived growth factor-B transcription by angiotensin_II in ECV304 cell line -RSB- .
10586083	0	NF-kappa_B	0,10	c-Rel	38,43	NF-kappa B	c-Rel	18033(Tax:10090)	19696(Tax:10090)	Gene	Gene	START_ENTITY|dep|Rel Rel|dep|hyperresponsiveness hyperresponsiveness|amod|END_ENTITY	NF-kappa_B / Rel transcription factors : c-Rel promotes airway hyperresponsiveness and allergic pulmonary_inflammation .
10823840	0	NF-kappa_B	42,52	c-Rel	126,131	NF-kappa B	c-Rel	4790	5966	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|phosphorylation phosphorylation|nmod|Ser-471 Ser-471|nmod|domain domain|nmod|END_ENTITY	Tumor_necrosis_factor-alpha activation of NF-kappa_B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel .
8505309	0	NF-kappa_B	87,97	c-Rel	69,74	NF-kappa B	c-Rel	4790	5966	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa_B proteins in human monocytic THP-1 cells .
8972019	0	NF-kappa_B	63,73	c-Rel	74,79	NF-kappa B	c-Rel	4790	5966	Gene	Gene	START_ENTITY|dep|translocation translocation|amod|END_ENTITY	Acetylsalicylic_acid and sodium_salicylate inhibit LPS-induced NF-kappa_B / c-Rel nuclear translocation , and synthesis of tissue factor -LRB- TF -RRB- and tumor necrosis factor alfa -LRB- TNF-alpha -RRB- in human monocytes .
7935451	0	NF-kappa_B	53,63	c-rel	169,174	NF-kappa B	c-rel	4790	5966	Gene	Gene	activation|nmod|START_ENTITY mediated|nsubj|activation mediated|dobj|induction induction|nmod|gene gene|amod|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
14527959	0	NF-kappa_B	66,76	cIAP-2	13,19	NF-kappa B	cIAP-2	4790	330	Gene	Gene	Induction|parataxis|START_ENTITY Induction|nmod|END_ENTITY	Induction of cIAP-2 in human colon_cancer cells through PKC_delta / NF-kappa_B .
9135156	0	NF-kappa_B	82,92	cRel	77,81	NF-kappa B	cRel	4790	5966	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	I_kappa_B_epsilon , a novel member of the I kappa B family , controls RelA and cRel NF-kappa_B activity .
10453032	0	NF-kappa_B	46,56	cyclooxygenase-2	91,107	NF-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	activation|amod|START_ENTITY activation|acl:relcl|promotes promotes|dobj|expression expression|amod|END_ENTITY	Superoxide attenuates macrophage apoptosis by NF-kappa_B and AP-1 activation that promotes cyclooxygenase-2 expression .
12230110	0	NF-kappa_B	146,156	cyclooxygenase-2	14,30	NF-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	activation|amod|START_ENTITY requires|dobj|activation requires|nsubj|Expression Expression|nmod|cytokines cytokines|amod|END_ENTITY	Expression of cyclooxygenase-2 and pro-inflammatory cytokines induced by 2,2 ' ,4,4 ' ,5,5 ' - hexachlorobiphenyl -LRB- PCB_153 -RRB- in human mast cells requires NF-kappa_B activation .
12646188	0	NF-kappa_B	62,72	cyclooxygenase-2	98,114	NF-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	activation|amod|START_ENTITY activation|acl:relcl|mediates mediates|dobj|expression expression|amod|END_ENTITY	Protein_kinase_C_alpha and zeta regulate nitric_oxide-induced NF-kappa_B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes .
19734210	0	NF-kappa_B	44,54	cyclooxygenase-2	70,86	NF-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	P2Y2 receptor transcription is increased by NF-kappa_B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells .
21104307	0	NF-kappa_B	109,119	cyclooxygenase-2	38,54	NF-kappa B	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY sites|amod|dependent sites|nsubj|activation activation|nmod|gene gene|amod|END_ENTITY	The transcriptional activation of the cyclooxygenase-2 gene in zymosan-activated macrophages is dependent on NF-kappa_B , C/EBP , AP-1 , and CRE sites .
19124728	0	NF-kappa_B	34,44	dUTPase	16,23	NF-kappa B	dUTPase	4790	34529(Tax:7227)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The EBV-encoded dUTPase activates NF-kappa_B through the TLR2 and MyD88-dependent signaling pathway .
7797515	0	NF-kappa_B	9,19	ferritin_H	41,51	NF-kappa B	ferritin H	18033(Tax:10090)	67634(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role for NF-kappa_B in the regulation of ferritin_H by tumor_necrosis_factor-alpha .
7688736	0	NF-kappa_B	51,61	gro-beta	38,46	NF-kappa B	gro-beta	4790	2920	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Interleukin-1-inducible expression of gro-beta via NF-kappa_B activation is dependent upon tyrosine kinase signaling .
12672017	0	NF-kappa_B	62,72	iNOS	90,94	NF-kappa B	iNOS	18033(Tax:10090)	18126(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|amod|END_ENTITY	p75_neurotrophin_receptor mediates neurotrophin activation of NF-kappa_B and induction of iNOS expression in P19 neurons .
10934190	1	NF-kappa_B	168,178	i_kappa_b_alpha	107,122	NF-kappa B	i kappa b alpha	4790	4792	Gene	Gene	homologue|nmod|START_ENTITY binding|nmod|homologue results|nmod|binding results|nsubj|release release|nmod|END_ENTITY	Signal-induced release of i_kappa_b_alpha results in binding of the viral homologue to NF-kappa_B .
7503239	0	NF-kappa_B	8,18	inducible_nitric_oxide_synthase	40,71	NF-kappa B	inducible nitric oxide synthase	18033(Tax:10090)	18126(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of NF-kappa_B in the regulation of inducible_nitric_oxide_synthase in an MTAL cell line .
9691914	0	NF-kappa_B	13,23	intercellular_adhesion_molecule_1	58,91	NF-kappa B	intercellular adhesion molecule 1	4790	25464(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Mediation by NF-kappa_B of cytokine induced expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in an intestinal epithelial cell line , a process blocked by proteasome inhibitors .
7537851	0	NF-kappa_B	59,69	interferon_regulatory_factor_1	12,42	NF-kappa B	interferon regulatory factor 1	18033(Tax:10090)	16362(Tax:10090)	Gene	Gene	cooperates|advcl|START_ENTITY cooperates|nsubj|END_ENTITY	Endothelial interferon_regulatory_factor_1 cooperates with NF-kappa_B as a transcriptional activator of vascular_cell_adhesion_molecule_1 .
7622454	0	NF-kappa_B	0,10	interleukin-1	25,38	NF-kappa B	interleukin-1	4790	3552	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	NF-kappa_B activation by interleukin-1 -LRB- IL-1 -RRB- requires an IL-1 receptor-associated protein kinase activity .
8244997	0	NF-kappa_B	12,22	interleukin-1	132,145	NF-kappa B	interleukin-1	4790	3552	Gene	Gene	factors|amod|START_ENTITY role|nmod|factors amyloid|nsubj|role amyloid|advcl|END_ENTITY	The role of NF-kappa_B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6 .
11583588	0	NF-kappa_B	134,144	interleukin-1-receptor-associated_kinase	27,67	NF-kappa B	interleukin-1-receptor-associated kinase	4790	3654	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Functional analysis of the interleukin-1-receptor-associated_kinase -LRB- IRAK-1 -RRB- in interleukin-1 beta-stimulated nuclear factor kappa B -LRB- NF-kappa_B -RRB- pathway activation : IRAK-1 associates with the NF-kappa_B essential modulator -LRB- NEMO -RRB- upon receptor stimulation .
7629057	0	NF-kappa_B	75,85	interleukin-1_beta	24,42	NF-kappa B	interleukin-1 beta	4790	3553	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Low affinity binding of interleukin-1_beta and intracellular signaling via NF-kappa_B identify Fit-1 as a distant member of the interleukin-1 receptor family .
9798528	0	NF-kappa_B	15,25	interleukin-1_beta	96,114	NF-kappa B	interleukin-1 beta	4790	24494(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Nuclear factor NF-kappa_B in myocardium : developmental expression of subunits and activation by interleukin-1_beta in cardiac myocytes in vitro .
11114294	0	NF-kappa_B	0,10	interleukin-1beta	77,94	NF-kappa B	interleukin-1beta	4790	3553	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	NF-kappa_B mediates up-regulation of CFTR gene expression in Calu-3 cells by interleukin-1beta .
11976320	0	NF-kappa_B	41,51	interleukin-1beta	14,31	NF-kappa B	interleukin-1beta	4790	3553	Gene	Gene	activation|amod|START_ENTITY induced|dobj|activation END_ENTITY|acl|induced	Inhibition of interleukin-1beta - induced NF-kappa_B activation by calcium/calmodulin-dependent _ protein_kinase_kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88 .
12909591	0	NF-kappa_B	23,33	interleukin-8	71,84	NF-kappa B	interleukin-8	4790	3576	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles for NF-kappa_B in endotoxin and oxygen induction of interleukin-8 in the macrophage .
8035808	0	NF-kappa_B	86,96	interleukin-8	34,47	NF-kappa B	interleukin-8	4790	3576	Gene	Gene	site|amod|START_ENTITY mediated|nmod|site mediated|nsubjpass|inhibition inhibition|nmod|gene gene|amod|END_ENTITY	Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa_B site .
8413215	0	NF-kappa_B	0,10	interleukin-8	46,59	NF-kappa B	interleukin-8	4790	3576	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	NF-kappa_B subunit-specific regulation of the interleukin-8 promoter .
1419905	0	NF-kappa_B	14,24	interleukin_2	28,41	NF-kappa B	interleukin 2	4790	3558	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of NF-kappa_B by interleukin_2 in human blood monocytes .
11783085	0	NF-kappa_B	58,68	latent_membrane_protein_1	5,30	NF-kappa B	latent membrane protein 1	4790	9260	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	-LSB- EBV latent_membrane_protein_1 induces p53 expression via NF-kappa_B in nasopharyngeal_carcinoma -RSB- .
10828070	0	NF-kappa_B	60,70	neuronal_cell_adhesion_molecule	14,45	NF-kappa B	neuronal cell adhesion molecule	4790	4897	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of neuronal_cell_adhesion_molecule expression by NF-kappa_B .
11887466	0	NF-kappa_B	32,42	nuclear_factor-kappa_B	8,30	NF-kappa B	nuclear factor-kappa B	4790	4790	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of nuclear_factor-kappa_B -LRB- NF-kappa_B -RRB- in inflammation , periodontitis , and atherogenesis .
7986199	0	NF-kappa_B	75,85	nuclear_factor_kappa_B	51,73	NF-kappa B	nuclear factor kappa B	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Pyrrolidine_dithiocarbamate , a potent inhibitor of nuclear_factor_kappa_B -LRB- NF-kappa_B -RRB- activation , prevents apoptosis in human promyelocytic_leukemia HL-60 cells and thymocytes .
8183915	0	NF-kappa_B	67,77	p105	62,66	NF-kappa B	p105	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa_B gene generates I kappa B_gamma isoforms with different inhibitory activities .
11006016	0	NF-kappa_B	0,10	p40	66,69	NF-kappa B	p40	18033(Tax:10090)	16160(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	NF-kappa_B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages : roles of PKC , PKA , ERK , p38_MAPK , and proteasome .
1547506	0	NF-kappa_B	107,117	p50	103,106	NF-kappa B	p50	4790	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa_B subunit .
1740105	0	NF-kappa_B	77,87	p50	62,65	NF-kappa B	p50	4790	4790	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa_B indicates that it participates in its own regulation .
2203532	0	NF-kappa_B	42,52	p50	15,18	NF-kappa B	p50	41087(Tax:7227)	44086(Tax:7227)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Cloning of the p50 DNA binding subunit of NF-kappa_B : homology to rel and dorsal .
8056331	0	NF-kappa_B	93,103	p50	78,81	NF-kappa B	p50	4790	4790	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa_B in vitro .
8416374	0	NF-kappa_B	42,52	p50	27,30	NF-kappa B	p50	4790	4790	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Mutational analysis of the p50 subunit of NF-kappa_B and inhibition of NF-kappa_B activity by trans-dominant p50 mutants .
11783085	0	NF-kappa_B	58,68	p53	39,42	NF-kappa B	p53	4790	7157	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- EBV latent_membrane_protein_1 induces p53 expression via NF-kappa_B in nasopharyngeal_carcinoma -RSB- .
12887889	0	NF-kappa_B	40,50	p53	0,3	NF-kappa B	p53	4790	7157	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	p53 - and Mdm2-independent repression of NF-kappa_B transactivation by the ARF_tumor suppressor .
17215959	0	NF-kappa_B	22,32	p53	15,18	NF-kappa B	p53	4790	7157	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling from p53 to NF-kappa_B determines the chemotherapy responsiveness of neuroblastoma .
17499812	0	NF-kappa_B	102,112	p53	78,81	NF-kappa B	p53	4790	7157	Gene	Gene	kinases|compound|START_ENTITY down-regulation|nmod|kinases pathways|nsubj|down-regulation pathways|ccomp|mediated mediated|nmod|induction induction|nmod|END_ENTITY	Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53 , down-regulation of NF-kappa_B and mitogen-activated protein kinases pathways .
21054790	0	NF-kappa_B	114,124	p53	92,95	NF-kappa B	p53	4790	7157	Gene	Gene	pathways|amod|START_ENTITY END_ENTITY|nmod|pathways	Fisetin , a dietary flavonoid , induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa_B pathways in bladder_cancer cells .
8051093	0	NF-kappa_B	0,10	p53	25,28	NF-kappa B	p53	4790	7157	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	NF-kappa_B activation of p53 .
8353285	0	NF-kappa_B	39,49	p56lck	137,143	NF-kappa B	p56lck	4790	3932	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Reactive oxygen intermediates activate NF-kappa_B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes .
11733537	0	NF-kappa_B	168,178	p65	153,156	NF-kappa B	p65	18033(Tax:10090)	19697(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Distinct roles of the Ikappa_B_kinase_alpha and beta subunits in liberating nuclear_factor_kappa_B -LRB- NF-kappa_B -RRB- from Ikappa B and in phosphorylating the p65 subunit of NF-kappa_B .
8114725	0	NF-kappa_B	116,126	p65	101,104	NF-kappa B	p65	4790	5970	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The bZIP transactivator of Epstein-Barr_virus , BZLF1 , functionally and physically interacts with the p65 subunit of NF-kappa_B .
8188306	0	NF-kappa_B	70,80	p65	34,37	NF-kappa B	p65	4790	5970	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa_B is located on chromosome 11q12 .
8199054	0	NF-kappa_B	70,80	p65	55,58	NF-kappa B	p65	447632(Tax:8355)	5970	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	XrelA , a Xenopus maternal and zygotic homologue of the p65 subunit of NF-kappa_B .
8234333	0	NF-kappa_B	43,53	p65	28,31	NF-kappa B	p65	18033(Tax:10090)	19697(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Antisense inhibition of the p65 subunit of NF-kappa_B blocks tumorigenicity and causes tumor regression .
12672017	0	NF-kappa_B	62,72	p75_neurotrophin_receptor	0,25	NF-kappa B	p75 neurotrophin receptor	18033(Tax:10090)	18053(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	p75_neurotrophin_receptor mediates neurotrophin activation of NF-kappa_B and induction of iNOS expression in P19 neurons .
11909978	0	NF-kappa_B	0,10	prostate-specific_antigen	21,46	NF-kappa B	prostate-specific antigen	4790	354	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	NF-kappa_B activates prostate-specific_antigen expression and is upregulated in androgen-independent prostate_cancer .
10716728	0	NF-kappa_B	0,10	protein_kinase_C-theta	83,105	NF-kappa B	protein kinase C-theta	4790	5588	Gene	Gene	activation|amod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|END_ENTITY	NF-kappa_B activation induced by T cell receptor/CD28 costimulation is mediated by protein_kinase_C-theta .
8035474	0	NF-kappa_B	86,96	rel	97,100	NF-kappa B	rel	4790	5966	Gene	Gene	transcription|nmod|START_ENTITY modulation|nmod|transcription induction|dep|modulation induction|dep|proteins proteins|compound|END_ENTITY	Viral induction of the human beta interferon promoter : modulation of transcription by NF-kappa_B / rel proteins and interferon regulatory factors .
8352966	0	NF-kappa_B	18,28	rel	29,32	NF-kappa B	rel	4790	5966	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|factor factor|compound|END_ENTITY	Regulation of the NF-kappa_B / rel transcription factor and I kappa B inhibitor system .
8918242	0	NF-kappa_B	32,42	relA	22,26	NF-kappa B	relA	18033(Tax:10090)	19697(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the murine relA -LRB- p65 NF-kappa_B -RRB- gene and comparison to the human gene reveals a distinct first intron .
9366421	0	NF-kappa_B	60,70	substance_P	17,28	NF-kappa B	substance P	4790	6863	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The neuropeptide substance_P activates transcription factor NF-kappa_B and kappa B-dependent gene expression in human astrocytoma cells .
2101630	0	NF-kappa_B	21,31	tax1	97,101	NF-kappa B	tax1	4790	6900	Gene	Gene	Induction|nmod|START_ENTITY DNA|nsubj|Induction DNA|nmod|protein protein|amod|END_ENTITY	Induction of nuclear NF-kappa_B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein .
8127864	0	NF-kappa_B	92,102	thioredoxin	20,31	NF-kappa B	thioredoxin	4790	7295	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa_B and AP-1 .
8093037	0	NF-kappa_B	58,68	thrombin	18,26	NF-kappa B	thrombin	4790	2147	Gene	Gene	activation|amod|START_ENTITY inhibiting|dobj|activation antagonizes|advcl|inhibiting antagonizes|dobj|signals signals|amod|END_ENTITY	E5510 antagonizes thrombin receptor signals by inhibiting NF-kappa_B activation .
9186620	0	NF-kappa_B	19,29	thrombin	126,134	NF-kappa B	thrombin	4790	2147	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Thrombin activates NF-kappa_B through thrombin receptor and results in proliferation of vascular smooth muscle cells : role of thrombin in atherosclerosis and restenosis .
9186620	0	NF-kappa_B	19,29	thrombin	38,46	NF-kappa B	thrombin	4790	2147	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Thrombin activates NF-kappa_B through thrombin receptor and results in proliferation of vascular smooth muscle cells : role of thrombin in atherosclerosis and restenosis .
10748079	0	NF-kappa_B	143,153	tumor_necrosis_factor-alpha	25,52	NF-kappa B	tumor necrosis factor-alpha	4790	7124	Gene	Gene	suppressing|nmod|START_ENTITY suppress|advcl|suppressing suppress|dobj|expression expression|amod|END_ENTITY	Glucocorticoids suppress tumor_necrosis_factor-alpha expression by human monocytic THP-1 cells by suppressing transactivation through adjacent NF-kappa_B and c-Jun-activating transcription factor-2 binding sites in the promoter .
11390371	0	NF-kappa_B	138,148	tumor_necrosis_factor-alpha	79,106	NF-kappa B	tumor necrosis factor-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor_necrosis_factor-alpha - and interleukin-1beta-induced NF-kappa_B activation .
11402028	0	NF-kappa_B	156,166	tumor_necrosis_factor-alpha	92,119	NF-kappa B	tumor necrosis factor-alpha	4790	7124	Gene	Gene	regulation|nmod|START_ENTITY coordinates|nmod|regulation coordinates|dobj|secretion secretion|amod|END_ENTITY	Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor_necrosis_factor-alpha secretion through IKK regulation of NF-kappa_B .
11445585	0	NF-kappa_B	120,130	tumor_necrosis_factor-alpha	157,184	NF-kappa B	tumor necrosis factor-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY regulating|dobj|activation regulating|nmod|END_ENTITY	Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase_A2s regulating NF-kappa_B activation in response to tumor_necrosis_factor-alpha and interleukin-1beta .
11729200	0	NF-kappa_B	90,100	tumor_necrosis_factor-alpha	53,80	NF-kappa B	tumor necrosis factor-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY induced|dobj|activation induced|dep|oxidase oxidase|nmod|mechanism mechanism|nmod|END_ENTITY	Role of neutrophil NADPH oxidase in the mechanism of tumor_necrosis_factor-alpha - induced NF-kappa_B activation and intercellular_adhesion_molecule-1 expression in endothelial cells .
12093792	0	NF-kappa_B	47,57	tumor_necrosis_factor-alpha	81,108	NF-kappa B	tumor necrosis factor-alpha	4790	7124	Gene	Gene	induction|amod|START_ENTITY modulates|dobj|induction modulates|nmod|cytokines cytokines|amod|END_ENTITY	A novel PAAD-containing protein that modulates NF-kappa_B induction by cytokines tumor_necrosis_factor-alpha and interleukin-1beta .
16464740	0	NF-kappa_B	65,75	tumor_necrosis_factor-alpha	24,51	NF-kappa B	tumor necrosis factor-alpha	4790	7124	Gene	Gene	I_kappa_B_alpha|compound|START_ENTITY END_ENTITY|nmod|I_kappa_B_alpha	Differential effects of tumor_necrosis_factor-alpha and CD40L on NF-kappa_B inhibitory proteins I_kappa_B_alpha , beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt_lymphoma cells .
7797515	0	NF-kappa_B	9,19	tumor_necrosis_factor-alpha	55,82	NF-kappa B	tumor necrosis factor-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role for NF-kappa_B in the regulation of ferritin_H by tumor_necrosis_factor-alpha .
9990294	0	NF-kappa_B	94,104	tumor_necrosis_factor-alpha	39,66	NF-kappa B	tumor necrosis factor-alpha	4790	7124	Gene	Gene	complex|amod|START_ENTITY mediated|nmod|complex mediated|nsubjpass|Stimulation Stimulation|nmod|synthesis synthesis|nmod|END_ENTITY	Stimulation of hyaluronan synthesis by tumor_necrosis_factor-alpha is mediated by the p50/p65 NF-kappa_B complex in MRC-5 myofibroblasts .
12566451	0	NF-kappa_B	9,19	tumor_necrosis_factor_alpha	59,86	NF-kappa B	tumor necrosis factor alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Impaired NF-kappa_B activation and increased production of tumor_necrosis_factor_alpha in transgenic_mice expressing keratin K10 in the basal layer of the epidermis .
12917325	0	NF-kappa_B	139,149	tumor_necrosis_factor_alpha	52,79	NF-kappa B	tumor necrosis factor alpha	4790	7124	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nmod|END_ENTITY	Expression of MIS in the testis is downregulated by tumor_necrosis_factor_alpha through the negative regulation of SF-1 transactivation by NF-kappa_B .
1653056	0	NF-kappa_B	0,10	tumor_necrosis_factor_alpha	25,52	NF-kappa B	tumor necrosis factor alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	NF-kappa_B activation by tumor_necrosis_factor_alpha in the Jurkat T cell line is independent of protein kinase A , protein_kinase_C , and Ca -LRB- 2 + -RRB- - regulated kinases .
7624137	0	NF-kappa_B	95,105	tumor_necrosis_factor_alpha	52,79	NF-kappa B	tumor necrosis factor alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	pattern|amod|START_ENTITY element|dep|pattern element|acl|located located|dobj|downstream downstream|nmod|gene gene|compound|END_ENTITY	Conserved kappa B element located downstream of the tumor_necrosis_factor_alpha gene : distinct NF-kappa_B binding pattern and enhancer activity in LPS activated murine macrophages .
7724598	0	NF-kappa_B	129,139	tumor_necrosis_factor_alpha	86,113	NF-kappa B	tumor necrosis factor alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY mediated|nmod|proteins mediated|nsubjpass|Induction Induction|nmod|gene gene|acl|encoding encoding|nmod|END_ENTITY	Induction of the gene encoding mucosal_vascular_addressin_cell_adhesion_molecule_1 by tumor_necrosis_factor_alpha is mediated by NF-kappa_B proteins .
8022202	0	NF-kappa_B	84,94	tumour_necrosis_factor	105,127	NF-kappa B	tumour necrosis factor	4790	7124	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa_B following tumour_necrosis_factor treatment of chronic B-leukaemia cells .
7537851	0	NF-kappa_B	59,69	vascular_cell_adhesion_molecule_1	104,137	NF-kappa B	vascular cell adhesion molecule 1	18033(Tax:10090)	22329(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	Endothelial interferon_regulatory_factor_1 cooperates with NF-kappa_B as a transcriptional activator of vascular_cell_adhesion_molecule_1 .
7692229	0	NF-kappa_B	89,99	vascular_cell_adhesion_molecule_1	27,60	NF-kappa B	vascular cell adhesion molecule 1	4790	7412	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Differential regulation of vascular_cell_adhesion_molecule_1 gene expression by specific NF-kappa_B subunits in endothelial and epithelial cells .
14966375	0	NF-kappa_B	119,129	vascular_endothelial_growth_factor_C	68,104	NF-kappa B	vascular endothelial growth factor C	4790	7424	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|advcl|activating	Overexpression of Her-2 / NEU in epithelial_ovarian_carcinoma induces vascular_endothelial_growth_factor_C by activating NF-kappa_B : implications for malignant ascites formation and tumor lymphangiogenesis .
16552041	0	NF-kappa_B-inducing_kinase	0,26	Nod2	69,73	NF-kappa B-inducing kinase	Nod2	53859(Tax:10090)	257632(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	NF-kappa_B-inducing_kinase regulates selected gene expression in the Nod2 signaling pathway .
7936632	0	NF-kappa_B_p65	64,78	Rel	41,44	NF-kappa B p65	Rel	5970	5966	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa_B_p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription .
14688382	0	NF-kappa_B_p65	0,14	c-maf	45,50	NF-kappa B p65	c-maf	5970	4094	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	NF-kappa_B_p65 antagonizes IL-4 induction by c-maf in minimal change_nephrotic_syndrome .
18181170	0	NF-kappabeta	79,91	MMP-9	55,60	NF-kappabeta	MMP-9	18033(Tax:10090)	17395(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Cytochrome P450 -LRB- CYP -RRB- 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia .
22489043	0	NF1	64,67	CBL	28,31	NF1	CBL	4763	867	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	NF1	64,67	DNMT3A	33,39	NF1	DNMT3A	4763	1788	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
9796699	0	NF1	0,3	Erk	75,78	NF1	Erk	18015(Tax:10090)	26413(Tax:10090)	Gene	Gene	inactivation|compound|START_ENTITY cooperates|nsubj|inactivation cooperates|nmod|lymphogenesis lymphogenesis|acl|activating activating|dobj|END_ENTITY	NF1 inactivation cooperates with N-ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity .
22489043	0	NF1	64,67	IDH1	41,45	NF1	IDH1	4763	3417	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	NF1	64,67	IDH2	47,51	NF1	IDH2	4763	3418	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	NF1	64,67	JAK2	53,57	NF1	JAK2	4763	3717	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	NF1	64,67	MPL	59,62	NF1	MPL	4763	4352	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
1786631	0	NF1	26,29	Neurofibromatosis_type_1	0,24	NF1	Neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Neurofibromatosis_type_1 -LRB- NF1 -RRB- gene : implication in neuroectodermal differentiation and genesis of brain_tumors .
22489043	0	NF1	64,67	SF3B1	69,74	NF1	SF3B1	4763	23451	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
8627811	0	NF1	18,21	Tax	30,33	NF1	Tax	4763	1491938(Tax:11908)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Repression of the NF1 gene by Tax may expain the development of neurofibromas in human_T-lymphotropic_virus_type_1 transgenic_mice .
24509877	0	NF1	62,65	mTOR	44,48	NF1	mTOR	4763	21977(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 .
10435592	0	NF1	56,59	neurofibromatosis	37,54	NF1	neurofibromatosis	4763	4763	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Site-specific DNA methylation in the neurofibromatosis -LRB- NF1 -RRB- promoter interferes with binding of CREB and SP1 transcription factors .
2506682	0	NF1	52,55	neurofibromatosis	33,50	NF1	neurofibromatosis	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Progress towards identifying the neurofibromatosis -LRB- NF1 -RRB- gene .
8385067	0	NF1	109,112	neurofibromatosis	90,107	NF1	neurofibromatosis	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of sporadic and inherited mutations in exon 31 of the neurofibromatosis -LRB- NF1 -RRB- gene .
8845843	0	NF1	69,72	neurofibromatosis	50,67	NF1	neurofibromatosis	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Site and sequence specific DNA methylation in the neurofibromatosis -LRB- NF1 -RRB- gene includes C5839T : the site of the recurrent substitution mutation in exon 31 .
11751683	0	NF1	44,47	neurofibromatosis_1	23,42	NF1	neurofibromatosis 1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Heterozygosity for the neurofibromatosis_1 -LRB- NF1 -RRB- tumor suppressor results in abnormalities in cell attachment , spreading and motility in astrocytes .
12077339	0	NF1	65,68	neurofibromatosis_1	39,58	NF1	neurofibromatosis 1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Astrocyte-specific inactivation of the neurofibromatosis_1 gene -LRB- NF1 -RRB- is insufficient for astrocytoma formation .
7542886	0	NF1	0,3	neurofibromatosis_1	36,55	NF1	neurofibromatosis 1	4763	4763	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	NF1 gene mutations in Japanese with neurofibromatosis_1 -LRB- NF1 -RRB- .
7579150	0	NF1	39,42	neurofibromatosis_1	18,37	NF1	neurofibromatosis 1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the neurofibromatosis_1 -LRB- NF1 -RRB- gene in reactive astrocytes in vitro .
7858173	0	NF1	61,64	neurofibromatosis_1	40,59	NF1	neurofibromatosis 1	4763	4763	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Tissue-specific alternative splicing of neurofibromatosis_1 -LRB- NF1 -RRB- mRNA .
8105688	0	NF1	51,54	neurofibromatosis_1	30,49	NF1	neurofibromatosis 1	4763	4763	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Linkage disequilibrium in the neurofibromatosis_1 -LRB- NF1 -RRB- region : implications for gene mapping .
8182944	0	NF1	53,56	neurofibromatosis_1	32,51	NF1	neurofibromatosis 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Absence of rearrangement of the neurofibromatosis_1 -LRB- NF1 -RRB- gene in myelodysplastic_syndromes and acute_myeloid_leukemia .
8730839	0	NF1	39,42	neurofibromatosis_1	18,37	NF1	neurofibromatosis 1	24592(Tax:10116)	24592(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the neurofibromatosis_1 -LRB- NF1 -RRB- gene during growth arrest .
8830850	0	NF1	94,97	neurofibromatosis_1	73,92	NF1	neurofibromatosis 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of a developmentally-regulated neuron-specific isoform of the neurofibromatosis_1 -LRB- NF1 -RRB- gene .
22807134	0	NF1	162,165	neurofibromatosis_type-1	136,160	NF1	neurofibromatosis type-1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein -LRB- GAP -RRB- - related domain of the neurofibromatosis_type-1 -LRB- NF1 -RRB- gene .
10360836	0	NF1	66,69	neurofibromatosis_type_1	40,64	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	EVI2B , a gene lying in an intron of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene , is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas .
10674164	0	NF1	102,105	neurofibromatosis_type_1	76,100	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel and very peculiar HincII polymorphism in the 5 ' region of the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
10684924	0	NF1	84,87	neurofibromatosis_type_1	58,82	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Cold_shock induces the insertion of a cryptic exon in the neurofibromatosis_type_1 -LRB- NF1 -RRB- mRNA .
10782929	0	NF1	78,81	neurofibromatosis_type_1	52,76	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular analysis of the 5 ' - flanking region of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene : identification of five sequence variants .
10878667	0	NF1	91,94	neurofibromatosis_type_1	65,89	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Segmental_neurofibromatosis is caused by somatic mutation of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
11129335	0	NF1	46,49	neurofibromatosis_type_1	20,44	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic loss at the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene locus is frequent in desmoplastic_neurotropic_melanoma .
11292340	0	NF1	50,53	neurofibromatosis_type_1	24,48	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene promotes skipping of two exons by preventing exon definition .
11735023	0	NF1	134,137	neurofibromatosis_type_1	107,131	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of denaturing high performance liquid chromatography -LRB- DHPLC -RRB- for the mutational analysis of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
11748857	0	NF1	105,108	neurofibromatosis_type_1	79,103	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of four novel large deletions in the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
12112660	0	NF1	59,62	neurofibromatosis_type_1	33,57	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ten novel mutations in the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in Italian patients .
1293177	0	NF1	30,33	neurofibromatosis_type_1	4,28	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The neurofibromatosis_type_1 -LRB- NF1 -RRB- gene : identification and partial characterization of a putative tumor suppressor gene .
14564162	0	NF1	69,72	neurofibromatosis_type_1	43,67	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A large deletion -LRB- 1.5 Mb -RRB- encompassing the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in a patient with sporadic NF1 associated with dysmorphism , mental_retardation , and unusual ocular and skeletal features .
14722917	0	NF1	85,88	neurofibromatosis_type_1	59,83	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the somatic mutational spectrum of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in neurofibromatosis patients with benign and malignant_tumors .
15523626	0	NF1	125,128	neurofibromatosis_type_1	99,123	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional analysis of polymorphic variation within the promoter and 5 ' untranslated region of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
16117786	0	NF1	60,63	neurofibromatosis_type_1	82,106	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Gonosomal mosaicism for a nonsense mutation -LRB- R1947X -RRB- in the NF1 gene in segmental neurofibromatosis_type_1 .
24676943	0	NF1	142,145	neurofibromatosis_type_1	116,140	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fast and robust next-generation sequencing technique using ion torrent personal genome machine for the screening of neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
26633276	0	NF1	109,112	neurofibromatosis_type_1	83,107	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Molecular diagnosis as a strategy for differential diagnosis and at early ages of neurofibromatosis_type_1 -LRB- NF1 -RRB- -RSB- .
7568895	0	NF1	44,47	neurofibromatosis_type_1	18,42	NF1	neurofibromatosis type 1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene during mouse embryonic development .
7607647	0	NF1	62,65	neurofibromatosis_type_1	36,60	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A Tsp509I variant in exon 13 of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene allows the identification of both alleles at the mRNA level .
7657385	0	NF1	68,71	neurofibromatosis_type_1	42,66	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the GAP-related domain of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in childhood brain_tumors .
8034304	0	NF1	61,64	neurofibromatosis_type_1	35,59	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A deletion in the 5 ' - region of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8207976	0	NF1	92,95	neurofibromatosis_type_1	66,90	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of mutations and expression of GAP-related domain of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in the progression of chronic_myelogenous_leukemia .
8225323	0	NF1	72,75	neurofibromatosis_type_1	46,70	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A de novo nonsense mutation in exon 28 of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8225327	0	NF1	99,102	neurofibromatosis_type_1	73,97	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A highly informative CA/GT repeat polymorphism in intron 38 of the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8320697	0	NF1	45,48	neurofibromatosis_type_1	19,43	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A genetic study of neurofibromatosis_type_1 -LRB- NF1 -RRB- in south-western Ontario .
8353492	0	NF1	96,99	neurofibromatosis_type_1	70,94	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel alleles , hemizygosity and deletions at an Alu-repeat within the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8364582	0	NF1	87,90	neurofibromatosis_type_1	61,85	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An alternatively-spliced mRNA in the carboxy terminus of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene is expressed in muscle .
8504305	0	NF1	61,64	neurofibromatosis_type_1	35,59	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Evidence of DNA methylation in the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene region of 17q11 .2 .
8530015	0	NF1	128,131	neurofibromatosis_type_1	102,126	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single-cell PCR performed with neurofibroma Schwann cells reveals the presence of both alleles of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8544190	0	NF1	72,75	neurofibromatosis_type_1	46,70	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterisation of germline mutations in the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
9003501	0	NF1	68,71	neurofibromatosis_type_1	42,66	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational and functional analysis of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
9150739	0	NF1	102,105	neurofibromatosis_type_1	76,100	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization and significance of nine novel mutations in exon 16 of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
9654211	0	NF1	49,52	neurofibromatosis_type_1	23,47	NF1	neurofibromatosis type 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gross deletions of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene are predominantly of maternal origin and commonly associated with a learning_disability , dysmorphic_features and developmental_delay .
22851646	0	NF1	62,65	neurofibromin_1	40,55	NF1	neurofibromin 1	4763	4763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparative oncogenomics implicates the neurofibromin_1 gene -LRB- NF1 -RRB- as a breast_cancer driver .
23208493	0	NF1C	35,39	AHR	14,17	NF1C	AHR	4782	196	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Inhibition of AHR transcription by NF1C is affected by a single-nucleotide polymorphism , and is involved in suppression of human_uterine_endometrial_cancer .
11668501	0	NF2	28,31	KRAS	45,49	NF2	KRAS	4771	3845	Gene	Gene	NRAS|compound|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
16324214	0	NF2	77,80	Neurofibromatosis_type_2	51,75	NF2	Neurofibromatosis type 2	4771	4771	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evolution and origin of merlin , the product of the Neurofibromatosis_type_2 -LRB- NF2 -RRB- tumor-suppressor gene .
11668501	0	NF2	28,31	PTEN	39,43	NF2	PTEN	4771	5728	Gene	Gene	NRAS|compound|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
11668501	0	NF2	28,31	TP53	33,37	NF2	TP53	4771	7157	Gene	Gene	NRAS|compound|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
15743831	0	NF2	4,7	merlin	39,45	NF2	merlin	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	The NF2 tumor suppressor gene product , merlin , inhibits cell proliferation and cell cycle progression by repressing cyclin_D1 expression .
14724586	0	NF2	57,60	neurofibromatosis_2	36,55	NF2	neurofibromatosis 2	4771	4771	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effect of merlin phosphorylation on neurofibromatosis_2 -LRB- NF2 -RRB- gene function .
7795605	0	NF2	39,42	neurofibromatosis_2	18,37	NF2	neurofibromatosis 2	25744(Tax:10116)	25744(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the neurofibromatosis_2 -LRB- NF2 -RRB- gene isoforms during rat embryonic development .
15681480	0	NF2	87,90	neurofibromatosis_type_2	61,85	NF2	neurofibromatosis type 2	4771	4771	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sensitive detection of deletions of one or more exons in the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene by multiplexed gene dosage polymerase chain reaction .
20831745	0	NF2	61,64	neurofibromatosis_type_2	35,59	NF2	neurofibromatosis type 2	4771	4771	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	CpG island hypermethylation of the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene is rare in sporadic vestibular_schwannomas .
7981675	0	NF2	63,66	neurofibromatosis_type_2	37,61	NF2	neurofibromatosis type 2	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Alternative transcripts in the mouse neurofibromatosis_type_2 -LRB- NF2 -RRB- gene are conserved and code for schwannomins with distinct C-terminal domains .
8655144	0	NF2	57,60	neurofibromatosis_type_2	31,55	NF2	neurofibromatosis type 2	4771	4771	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Screening for mutations in the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene in sporadic_meningiomas .
8755919	0	NF2	55,58	neurofibromatosis_type_2	24,48	NF2	neurofibromatosis type 2	4771	4771	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Type of mutation in the neurofibromatosis_type_2 gene -LRB- NF2 -RRB- frequently determines severity of disease .
9225971	0	NF2	76,79	neurofibromatosis_type_2	50,74	NF2	neurofibromatosis type 2	4771	4771	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis and expression studies of the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene in a patient with a ring_chromosome_22_and_NF2 .
16324214	0	NF2	77,80	tumor-suppressor	82,98	NF2	tumor-suppressor	4771	7248	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evolution and origin of merlin , the product of the Neurofibromatosis_type_2 -LRB- NF2 -RRB- tumor-suppressor gene .
7829260	0	NF2	16,19	tumor-suppressor	20,36	NF2	tumor-suppressor	4771	7248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Analysis of the NF2 tumor-suppressor gene and of chromosome 22 deletions in gliomas .
20051514	0	NF45	0,4	interleukin-13	37,51	NF45	interleukin-13	3608	3596	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells .
16055709	0	NF90	21,25	ADAR1	0,5	NF90	ADAR1	3609	103	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing .
17470640	0	NF90	0,4	IL-2	25,29	NF90	IL-2	16201(Tax:10090)	16183(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	NF90 regulates inducible IL-2 gene expression in T cells .
18097023	0	NF90	18,22	IL-2	36,40	NF90	IL-2	3609	3558	Gene	Gene	export|nmod|START_ENTITY export|acl|stabilize stabilize|dobj|mRNA mRNA|compound|END_ENTITY	Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation .
12954875	0	NFAT	48,52	Brain-derived_neurotrophic_factor	0,33	NFAT	Brain-derived neurotrophic factor	307820(Tax:10116)	24225(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of NFAT -LRB- nuclear_factor_of_activated_T-cells -RRB- - dependent transcription : a role for the transcription factor NFATc4 in neurotrophin-mediated gene expression .
11287617	0	NFAT	127,131	interleukin-2	144,157	NFAT	interleukin-2	4773	3558	Gene	Gene	site|compound|START_ENTITY site|nmod|promoter promoter|compound|END_ENTITY	Vav-Rac1-mediated activation of the c-Jun_N-terminal_kinase / c-Jun/AP -1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter .
21282105	0	NFAT1	76,81	CD4	92,95	NFAT1	CD4	4773	920	Gene	Gene	1|appos|START_ENTITY 1|nmod|cells cells|compound|END_ENTITY	Minocycline suppresses activation of nuclear factor of activated T cells 1 -LRB- NFAT1 -RRB- in human CD4 + T cells .
22865456	0	NFAT1	0,5	CD4	39,42	NFAT1	CD4	18019(Tax:10090)	12504(Tax:10090)	Gene	Gene	supports|nsubj|START_ENTITY supports|dobj|cells cells|compound|anergy anergy|nmod|T T|compound|END_ENTITY	NFAT1 supports tumor-induced anergy of CD4 -LRB- + -RRB- T cells .
24173147	0	NFAT1	94,99	CD4	118,121	NFAT1	CD4	4773	920	Gene	Gene	START_ENTITY|nmod|proliferation proliferation|compound|END_ENTITY	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
24173147	0	NFAT1	94,99	CD4	40,43	NFAT1	CD4	4773	920	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|expression expression|nmod|+ +|compound|END_ENTITY	Differential CTLA-4 expression in human CD4 + versus CD8 + T cells is associated with increased NFAT1 and inhibition of CD4 + proliferation .
25595785	0	NFAT1	0,5	CD4	63,66	NFAT1	CD4	18019(Tax:10090)	12504(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4 + T Cells in Health and Disease .
18962896	0	NFAT1	49,54	IL-10	73,78	NFAT1	IL-10	18019(Tax:10090)	16153(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	A distal cis-regulatory element , CNS-9 , controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells .
22627363	0	NFAT1	0,5	IL-17A	40,46	NFAT1	IL-17A	4773	3605	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells .
25595785	0	NFAT1	0,5	IL-31	38,43	NFAT1	IL-31	18019(Tax:10090)	76399(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4 + T Cells in Health and Disease .
27013197	0	NFAT1	0,5	IL-8	25,29	NFAT1	IL-8	4773	3576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	NFAT1 directly regulates IL-8 and MMP-3 to promote melanoma_tumor growth and metastasis .
22333584	0	NFAT1	52,57	c-Myc	34,39	NFAT1	c-Myc	4773	4609	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements .
23060442	0	NFAT1	275,280	nuclear_factor_of_activated_T_cell_1	237,273	NFAT1	nuclear factor of activated T cell 1	4773	4773	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 -LRB- VEGFR2 -RRB- - evoked signaling pathways : transcriptional repression of hypoxia-inducible_factor_1a and VEGFA and concurrent inhibition of nuclear_factor_of_activated_T_cell_1 -LRB- NFAT1 -RRB- activation .
23340267	0	NFAT2	0,5	Bax	84,87	NFAT2	Bax	18018(Tax:10090)	12028(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|expression expression|compound|END_ENTITY	NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression .
20375015	0	NFAT2	116,121	Bmp7	140,144	NFAT2	Bmp7	18018(Tax:10090)	12162(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of embryonic_kidney branching morphogenesis and glomerular development by KISS1_receptor -LRB- Gpr54 -RRB- through NFAT2 - and Sp1-mediated Bmp7 expression .
16355273	0	NFAT2	24,29	CCR1	0,4	NFAT2	CCR1	18018(Tax:10090)	12768(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration .
24657343	0	NFAT2	0,5	COX-2	16,21	NFAT2	COX-2	4772	4513	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	NFAT2 regulates COX-2 expression and modulates the integrin repertoire in endothelial cells at the crossroads of angiogenesis and inflammation .
19564342	0	NFAT2	34,39	FOXP3	0,5	FOXP3	FOXP3	50943	50943	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression .
23924068	8	NFAT2	1526,1531	IL-2	1547,1551	NFAT2	IL-2	4772	3558	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Although NFAT2 mRNA levels were unaffected , chromatin immunoprecipitation -LRB- ChIP -RRB- for NFAT2 indicated decreased NFAT2 binding at the IL-2 promoter in suppressed Th cells .
25514788	0	NFAT3	15,20	CXCR4	51,56	NFAT3	CXCR4	4776	7852	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Novel Role for NFAT3 in ERK-Mediated Regulation of CXCR4 .
24355664	0	NFAT5	91,96	MiR-568	0,7	NFAT5	MiR-568	10725	693153	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-568 inhibits the activation and function of CD4 T cells and Treg cells by targeting NFAT5 .
18156209	0	NFATC1	80,86	nuclear_factor_of_activated_T_cell_1	42,78	NFATC1	nuclear factor of activated T cell 1	4772	4772	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Epigenetic changes and suppression of the nuclear_factor_of_activated_T_cell_1 -LRB- NFATC1 -RRB- promoter in human lymphomas with defects in immunoreceptor signaling .
18081741	0	NFAT_1	107,113	nuclear_factor_of_activated_T_cells_1	68,105	NFAT 1	nuclear factor of activated T cells 1	4773	4773	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Disrupted intracellular calcium regulates BACE1 gene expression via nuclear_factor_of_activated_T_cells_1 -LRB- NFAT_1 -RRB- signaling .
26600673	0	NFATc1	16,22	CD137	0,5	NFATc1	CD137	18018(Tax:10090)	21942(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	CD137 Regulates NFATc1 Expression in Mouse VSMCs through TRAF6/NF-kB p65 Signaling Pathway .
19933579	0	NFATc1	40,46	Cyclin_D1	0,9	NFATc1	Cyclin D1	4772	595	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Cyclin_D1 is a bona fide target gene of NFATc1 and is sufficient in the mediation of injury-induced vascular wall remodeling .
25623042	0	NFATc1	0,6	EGFR	13,17	NFATc1	EGFR	18018(Tax:10090)	13649(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal_Transdifferentiation_in_the_Pancreas .
26343857	0	NFATc1	89,95	ERK1/2	54,60	NFATc1	ERK1/2	4772	5595;5594	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Insulin enhances RANKL-induced osteoclastogenesis via ERK1/2 activation and induction of NFATc1 and Atp6v0d2 .
19607912	0	NFATc1	14,20	IL-13	50,55	NFATc1	IL-13	4772	3596	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	JNK-dependent NFATc1 pathway positively regulates IL-13 gene expression induced by -LRB- - -RRB- - epigallocatechin-3-gallate in human basophilic KU812 cells .
17627913	0	NFATc1	53,59	Interleukin-10	0,14	NFATc1	Interleukin-10	18018(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264 .7 cells and mouse bone marrow cells .
15752732	0	NFATc1	51,57	Interleukin-4	0,13	NFATc1	Interleukin-4	18018(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits RANKL-induced expression of NFATc1 and c-Fos : a possible mechanism for downregulation of osteoclastogenesis .
21751242	0	NFATc1	37,43	Interleukin-4	0,13	NFATc1	Interleukin-4	4772	3565	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6 : a novel mechanism mediating its blockade of osteoclastogenesis .
24680826	0	NFATc1	59,65	KLF15	0,5	NFATc1	KLF15	18018(Tax:10090)	66277(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	KLF15 regulates slow myosin heavy chain expression through NFATc1 in C2C12 myotubes .
22792407	0	NFATc1	18,24	MIP-1	0,5	NFATc1	MIP-1	18018(Tax:10090)	238799(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	MIP-1 activates NFATc1 and enhances osteoclastogenesis : involvement of both PLCy2 and NFkB signaling .
25152440	0	NFATc1	48,54	Mitf	0,4	NFATc1	Mitf	18018(Tax:10090)	17342(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY modulating|dobj|activity regulates|advcl|modulating regulates|nsubj|END_ENTITY	Mitf regulates osteoclastogenesis by modulating NFATc1 activity .
15567162	0	NFATc1	33,39	RANK-L	0,6	NFATc1	RANK-L	18018(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	RANK-L induces the expression of NFATc1 , but not of NFkappaB subunits during osteoclast formation .
21751242	0	NFATc1	37,43	STAT6	59,64	NFATc1	STAT6	4772	6778	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6 : a novel mechanism mediating its blockade of osteoclastogenesis .
25623042	0	NFATc1	0,6	Sox9	44,48	NFATc1	Sox9	18018(Tax:10090)	20682(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Transcription Transcription|compound|END_ENTITY	NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal_Transdifferentiation_in_the_Pancreas .
21603612	0	NFATc1	0,6	TRAIL	21,26	NFATc1	TRAIL	4772	8743	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	NFATc1 regulation of TRAIL expression in human intestinal cells .
19661463	0	NFATc1	29,35	VEGF	0,4	NFATc1	VEGF	18018(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	VEGF and RANKL regulation of NFATc1 in heart valve development .
16513293	0	NFATc1	0,6	beta3	31,36	NFATc1	beta3	4772	1934	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation .
18846253	0	NFATc1	0,6	osteoprotegerin	25,40	NFATc1	osteoprotegerin	18018(Tax:10090)	18383(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism .
26823495	0	NFATc2	36,42	GSK-3b	0,6	NFATc2	GSK-3b	18019(Tax:10090)	56637(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	GSK-3b Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic_Cancer_Progression .
11956291	0	NFATc2	53,59	Interferon_regulatory_factor_4	0,30	NFATc2	Interferon regulatory factor 4	18019(Tax:10090)	16364(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Interferon_regulatory_factor_4 -LRB- IRF4 -RRB- interacts with NFATc2 to modulate interleukin_4 gene expression .
11786533	0	NFATc2	40,46	Nfatc1	25,31	NFATc2	Nfatc1	18019(Tax:10090)	18018(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of the murine Nfatc1 gene by NFATc2 .
17103021	0	NFATc2	14,20	Runx2	65,70	NFATc2	Runx2	18019(Tax:10090)	12393(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of NFATc2 gene expression by the transcription factor Runx2 .
24561192	0	NFATc2	33,39	USP22	0,5	NFATc2	USP22	4773	23326	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	USP22 is a positive regulator of NFATc2 on promoting IL2 expression .
12093869	0	NFATc2	13,19	interleukin_6	34,47	NFATc2	interleukin 6	4773	3569	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of NFATc2 expression by interleukin_6 promotes T helper type 2 differentiation .
26697077	0	NFATc4	0,6	Sox9	17,21	NFATc4	Sox9	4776	6662	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic_Cancer_Initiation .
11997522	0	NFATc4	19,25	p38	29,32	NFATc4	p38	73181(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases .
8397339	0	NFATp	32,37	Fos	88,91	NFATp	Fos	4773	2353	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. .
8816436	0	NFATp	102,107	tumor_necrosis_factor_alpha	43,70	NFATp	tumor necrosis factor alpha	4773	7124	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Cell-type-specific regulation of the human tumor_necrosis_factor_alpha gene in B cells and T cells by NFATp and ATF-2 / JUN. .
8943040	0	NFE2	22,26	NRF2	0,4	NFE2	NRF2	18022(Tax:10090)	18024(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	NRF2 , a member of the NFE2 family of transcription factors , is not essential for murine erythropoiesis , growth , and development .
22493435	0	NFE2L2	121,127	B-cell_translocation_gene_2	0,27	NFE2L2	B-cell translocation gene 2	4780	7832	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	B-cell_translocation_gene_2 -LRB- BTG2 -RRB- stimulates cellular antioxidant defenses through the antioxidant transcription factor NFE2L2 in human mammary epithelial cells .
22614957	0	NFE2L2	21,27	NRF2	10,14	NFE2L2	NRF2	4780	4780	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Increased NRF2 gene -LRB- NFE2L2 -RRB- copy number correlates with mutations in lung_squamous_cell_carcinomas .
17130157	0	NFI	85,88	cyclin-dependent_kinase_inhibitor_1A	34,70	NFI	cyclin-dependent kinase inhibitor 1A	4782	1026	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the cyclin-dependent_kinase_inhibitor_1A -LRB- p21 -RRB- gene by NFI in proliferating human cells .
2841167	0	NFI	64,67	nuclear_factor_I	46,62	NFI	nuclear factor I	4782	4782	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation and characterization of the porcine nuclear_factor_I -LRB- NFI -RRB- gene .
8725173	0	NFIL-6	14,20	basic_fibroblast_growth_factor	44,74	NFIL-6	basic fibroblast growth factor	12608(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of NFIL-6 and IL-6 expression by basic_fibroblast_growth_factor in osteoblasts .
11162511	0	NFIL6	37,42	HSP70B	18,24	NFIL6	HSP70B	1051	3311	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Repression of the HSP70B promoter by NFIL6 , Ku70 , and MAPK involves three complementary mechanisms .
20826536	0	NFKB	82,86	PTGS2	37,42	NFKB	PTGS2	309165(Tax:10116)	29527(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Prostaglandin_F2a -LRB- PGF2a -RRB- stimulates PTGS2 expression and PGF2a synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats .
18666137	0	NFKB1	47,52	IL-1A	25,30	NFKB1	IL-1A	4790	3552	Gene	Gene	FAS|appos|START_ENTITY FAS|compound|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
18666137	0	NFKB1	47,52	IL-1B	32,37	NFKB1	IL-1B	4790	3553	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
18666137	0	NFKB1	47,52	IL-1RN	39,45	NFKB1	IL-1RN	4790	3557	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	Genetic polymorphisms of IL-1A , IL-1B , IL-1RN , NFKB1 , FAS , and FASL , and risk of silicosis in a Chinese occupational population .
24971461	0	NFKB1	80,85	TLR4	54,58	NFKB1	TLR4	4790	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
9529131	0	NFKB2	20,25	p100	14,18	NFKB2	p100	4791	4791	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of p100 -LRB- NFKB2 -RRB- expression in human monocytes in response to inflammatory mediators and lymphokines .
16540234	0	NFKBIA	54,60	I_kappa_B_alpha	32,47	NFKBIA	I kappa B alpha	4792	4792	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Haplotypic structure across the I_kappa_B_alpha gene -LRB- NFKBIA -RRB- and association with multiple_myeloma .
24971461	0	NFKBIA	72,78	TLR4	54,58	NFKBIA	TLR4	4792	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
11246458	0	NFKBIL2	78,85	IkappaBR	63,71	NFKBIL2	IkappaBR	4796	4796	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation , sequence , and chromosomal localisation of the human IkappaBR gene -LRB- NFKBIL2 -RRB- .
19619516	0	NFL	89,92	caspase_3	65,74	NFL	caspase 3	18039(Tax:10090)	12367(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Cytosolic TDP-43 expression following axotomy is associated with caspase_3 activation in NFL - / - mice : support for a role for TDP-43 in the physiological response to neuronal_injury .
22434040	0	NFR5	37,41	ROP6	17,21	NFR5	ROP6	100034751(Tax:34305)	829654(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The small GTPase ROP6 interacts with NFR5 and is involved in nodule formation in Lotus_japonicus .
25597503	0	NFS1	56,60	ISCU	80,84	NFS1	ISCU	9054	23479	Gene	Gene	persulfide|compound|START_ENTITY transfer|nmod|persulfide enhances|dobj|transfer enhances|nmod|thiols thiols|amod|END_ENTITY	Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols .
19908244	0	NF_kappaB	31,40	GW112	17,22	NF kappaB	GW112	4790	10562	Gene	Gene	Gene|nmod|START_ENTITY Gene|compound|END_ENTITY	Up regulation of GW112 Gene by NF_kappaB promotes an antiapoptotic property in gastric_cancer cells .
11337492	0	NF_kappa_B	33,43	Dbl	0,3	NF kappa B	Dbl	4790	4168	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Dbl and the Rho GTPases activate NF_kappa_B by I kappa B kinase -LRB- IKK -RRB- - dependent and IKK-independent pathways .
1624799	0	NF_kappa_B	42,52	IFN-gamma	0,9	NF kappa B	IFN-gamma	18033(Tax:10090)	15978(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	IFN-gamma and IL-2 cooperatively activate NF_kappa_B in murine peritoneal macrophages .
12429743	0	NF_kappa_B	54,64	I_kappa_B_alpha	28,43	NF kappa B	I kappa B alpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of I_kappa_B_alpha activates NF_kappa_B through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation .
14690537	0	NF_kappa_B	123,133	I_kappa_B_alpha	84,99	NF kappa B	I kappa B alpha	18033(Tax:10090)	18035(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Protection by pioglitazone in the MPTP model of Parkinson 's _ disease correlates with I_kappa_B_alpha induction and block of NF_kappa_B and iNOS activation .
7488149	0	NF_kappa_B	18,28	I_kappa_B_alpha	97,112	NF kappa B	I kappa B alpha	4790	4792	Gene	Gene	activation|compound|START_ENTITY blocks|dobj|activation blocks|advcl|inhibiting inhibiting|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Cupric ion blocks NF_kappa_B activation through inhibiting the signal-induced phosphorylation of I_kappa_B_alpha .
1883525	0	NF_kappa_B	91,101	M-CSF	14,19	NF kappa B	M-CSF	4790	1435	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of M-CSF expression by M-CSF : role of protein_kinase_C and transcription factor NF_kappa_B .
12170775	0	NF_kappa_B	56,66	Par-4	0,5	NF kappa B	Par-4	4790	347745	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Par-4 , a pro-apoptotic gene , inhibits radiation-induced NF_kappa_B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate_cancer cells PC-3 .
12650962	0	NF_kappa_B	57,67	caspase-1	68,77	NF kappa B	caspase-1	18033(Tax:10090)	12362(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Light-induced photoreceptor_degeneration may involve the NF_kappa_B / caspase-1 pathway in vivo .
11477102	0	NF_kappa_B	71,81	interleukin-18	17,31	NF kappa B	interleukin-18	4790	3606	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	A novel role for interleukin-18 in adhesion molecule induction through NF_kappa_B and phosphatidylinositol -LRB- PI -RRB- 3-kinase-dependent signal transduction pathways .
19892878	0	NF_kappa_B	62,72	nuclear_factor-kappa_B	38,60	NF kappa B	nuclear factor-kappa B	4790	4790	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Characterizing the involvement of the nuclear_factor-kappa_B -LRB- NF_kappa_B -RRB- transcription factor in uveal_melanoma .
7721885	0	NF_kappa_B	53,63	nuclear_factor_kappa_B	29,51	NF kappa B	nuclear factor kappa B	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Interleukin _ -LRB- IL -RRB- -10 inhibits nuclear_factor_kappa_B -LRB- NF_kappa_B -RRB- activation in human monocytes .
8151120	0	NF_kappa_B	42,52	nuclear_factor_kappa_B	18,40	NF kappa B	nuclear factor kappa B	4790	4790	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	UVB light induces nuclear_factor_kappa_B -LRB- NF_kappa_B -RRB- activity independently from chromosomal DNA damage in cell-free cytosolic extracts .
8065920	0	NF_kappa_B	97,107	p50	82,85	NF kappa B	p50	4790	4790	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Sequence-specific interaction of alpha-beta-anomeric double-stranded DNA with the p50 subunit of NF_kappa_B : application to the decoy approach .
15707575	0	NF_kappa_B	73,83	p75NTR	4,10	NF kappa B	p75NTR	4790	4804	Gene	Gene	pathways|compound|START_ENTITY mediates|nmod|pathways mediates|nsubj|END_ENTITY	The p75NTR mediates a bifurcated signal transduction cascade through the NF_kappa_B and JNK pathways to inhibit cell survival .
12801933	0	NF_kappa_B1	37,48	p50	50,53	NF kappa B1	p50	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The MEK/ERK pathway acts upstream of NF_kappa_B1 -LRB- p50 -RRB- homodimer activity and Bcl-2 expression in a murine B-cell_lymphoma cell line .
12600083	0	NF_kappa_Bp65	48,61	nuclear_factor_kappa_Bp65	21,46	NF kappa Bp65	nuclear factor kappa Bp65	5970	5970	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- The significance of nuclear_factor_kappa_Bp65 -LRB- NF_kappa_Bp65 -RRB- expression on the vascular endothelial cells of rectum adenocarcinoma of human -RSB- .
24819963	0	NFk-B	75,80	AP-1	82,86	NFk-B	AP-1	81736(Tax:10116)	24516(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
24819963	0	NFk-B	75,80	Bax	53,56	NFk-B	Bax	81736(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
24819963	0	NFk-B	75,80	Bcl-2	58,63	NFk-B	Bcl-2	81736(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
24819963	0	NFk-B	75,80	CREB	88,92	NFk-B	CREB	81736(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Apricot attenuates oxidative stress and modulates of Bax , Bcl-2 , caspases , NFk-B , AP-1 , CREB expression of rats bearing DMBA-induced liver_damage and treated with a combination of radiotherapy .
22286145	0	NFkB	67,71	P65	72,75	NFkB	P65	309165(Tax:10116)	25716(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Ischemia-reperfusion_injury in rat steatotic liver is dependent on NFkB P65 activation .
22381741	0	NFkB	61,65	TGF-b	39,44	NFkB	TGF-b	81736(Tax:10116)	59086(Tax:10116)	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Sulfasalazine prevents the increase in TGF-b , COX-2 , nuclear NFkB translocation and fibrosis in CCl4-induced liver_cirrhosis in the rat .
26285747	0	NFkB	66,70	VEGF	80,84	NFkB	VEGF	81736(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Promoter Promoter|compound|END_ENTITY	Chromatin Immunoprecipitation Assay : Examining the Interaction of NFkB with the VEGF Promoter .
25928697	0	NFkB	104,108	angiotensin_II	75,89	NFkB	angiotensin II	81736(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Skeletal muscle insulin resistance in salt-sensitive hypertension : role of angiotensin_II activation of NFkB .
24068327	0	NFkB1	0,5	SOD2	23,27	NFkB1	SOD2	18033(Tax:10090)	20656(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	NFkB1 -LRB- p50 -RRB- suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis .
17487836	0	NFkappaB	26,34	Androgen_receptor	0,17	NFkappaB	Androgen receptor	18033(Tax:10090)	11835(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Androgen_receptor targets NFkappaB and TSP1 to suppress prostate_tumor growth in vivo .
9727009	0	NFkappaB	41,49	Bcl-2	0,5	NFkappaB	Bcl-2	4790	596	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Bcl-2 activates the transcription factor NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha .
15389813	0	NFkappaB	47,55	C/EBP-beta	96,106	NFkappaB	C/EBP-beta	4790	1051	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Co-operative functions between nuclear factors NFkappaB and CCAT/enhancer-binding protein-beta -LRB- C/EBP-beta -RRB- regulate the IL-6 promoter in autocrine human prostate_cancer cells .
10949181	0	NFkappaB	128,136	CD154	92,97	NFkappaB	CD154	18033(Tax:10090)	21947(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Differential effects of cyclosporine_A , methylprednisolone , mycophenolate , and rapamycin on CD154 induction and requirement for NFkappaB : implications for tolerance induction .
19247502	0	NFkappaB	32,40	CFTR	0,4	NFkappaB	CFTR	4790	1080	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	CFTR is a negative regulator of NFkappaB mediated innate immune response .
12349897	0	NFkappaB	149,157	COX-2	124,129	NFkappaB	COX-2	4790	5743	Gene	Gene	transcription|nmod|START_ENTITY transcription|appos|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
15924567	0	NFkappaB	108,116	ERK2	97,101	NFkappaB	ERK2	4790	5594	Gene	Gene	cascade|compound|START_ENTITY cascade|compound|END_ENTITY	17beta-oestradiol up-regulates longevity-related , antioxidant enzyme expression via the ERK1 and ERK2 -LSB- MAPK -RSB- / NFkappaB cascade .
15289496	0	NFkappaB	0,8	FADD	47,51	NFkappaB	FADD	4790	8772	Gene	Gene	activation|amod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|END_ENTITY	NFkappaB activation by Fas is mediated through FADD , caspase-8 , and RIP and is inhibited by FLIP .
19008357	0	NFkappaB	49,57	G-protein-coupled_receptor_kinase_5	4,39	NFkappaB	G-protein-coupled receptor kinase 5	4790	2869	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	The G-protein-coupled_receptor_kinase_5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB_alpha .
18199827	0	NFkappaB	64,72	HIF-1alpha	0,10	NFkappaB	HIF-1alpha	18033(Tax:10090)	15251(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling .
16274703	0	NFkappaB	87,95	Ha-ras	99,105	NFkappaB	Ha-ras	18033(Tax:10090)	15461(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Dominant-negative Rac1 suppresses Ras-induced apoptosis possibly through activation of NFkappaB in Ha-ras oncogene-transformed NIH/3T3 cells .
9808178	0	NFkappaB	64,72	IL-2	85,89	NFkappaB	IL-2	18033(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|dep|END_ENTITY	Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation , IL-2 production and stress-activated protein kinases in the murine T cell line EL4 .
12921778	0	NFkappaB	45,53	IkappaBalpha	85,97	NFkappaB	IkappaBalpha	4790	4792	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Okadaic_acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils .
11232040	0	NFkappaB	17,25	Insulin	0,7	NFkappaB	Insulin	4790	3630	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Insulin inhibits NFkappaB and MCP-1 expression in human aortic endothelial cells .
16286467	0	NFkappaB	31,39	Interleukin-1beta	0,17	NFkappaB	Interleukin-1beta	4790	3553	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase .
18262272	0	NFkappaB	98,106	Interleukin-1beta	0,17	NFkappaB	Interleukin-1beta	4790	3553	Gene	Gene	inducing|dobj|START_ENTITY stimulates|advcl|inducing stimulates|nsubj|END_ENTITY	Interleukin-1beta stimulates acute phase response and C-reactive_protein synthesis by inducing an NFkappaB - and C/EBPbeta-dependent autocrine interleukin-6 loop .
19609947	0	NFkappaB	27,35	NFkappaB	61,69	NFkappaB	NFkappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt .
19609947	0	NFkappaB	61,69	NFkappaB	27,35	NFkappaB	NFkappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt .
11491660	0	NFkappaB	28,36	NFkappaB-inducing_kinase	76,100	NFkappaB	NFkappaB-inducing kinase	4790	9020	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	Hydrogen_peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing_kinase .
19019824	0	NFkappaB	94,102	Nef	6,9	NFkappaB	Nef	4790	6285	Gene	Gene	inhibiting|dobj|START_ENTITY inhibits|advcl|inhibiting inhibits|nsubj|END_ENTITY	HIV-1 Nef inhibits lipopolysaccharide-induced IL-12p40 expression by inhibiting JNK-activated NFkappaB in human monocytic cells .
18953692	0	NFkappaB	34,42	PTEN	17,21	NFkappaB	PTEN	4790	5728	Gene	Gene	regulate|dobj|START_ENTITY targets|xcomp|regulate targets|dobj|END_ENTITY	Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast_tumor growth .
20060890	0	NFkappaB	56,64	PTEN	36,40	NFkappaB	PTEN	4790	5728	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast_cancer cell growth .
12676934	0	NFkappaB	48,56	Protein_kinase_C-associated_kinase	0,34	NFkappaB	Protein kinase C-associated kinase	4790	54101	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Protein_kinase_C-associated_kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner .
16259979	0	NFkappaB	72,80	Smad7	0,5	NFkappaB	Smad7	4790	4092	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB .
15943902	0	NFkappaB	87,95	TNF	49,52	NFkappaB	TNF	4790	7124	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Distinct differences between TNF receptor 1 - and TNF receptor 2-mediated activation of NFkappaB .
19112497	0	NFkappaB	55,63	TRAF6	0,5	NFkappaB	TRAF6	4790	7189	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL .
10085086	0	NFkappaB	65,73	Tumor_necrosis_factor	0,21	NFkappaB	Tumor necrosis factor	4790	7124	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Tumor_necrosis_factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons .
14563845	0	NFkappaB	38,46	Tumor_necrosis_factor-alpha	0,27	NFkappaB	Tumor necrosis factor-alpha	18033(Tax:10090)	21926(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha activates NFkappaB to inhibit renin transcription by targeting cAMP-responsive element .
16410078	0	NFkappaB	87,95	Vascular_endothelial_growth_factor	0,34	NFkappaB	Vascular endothelial growth factor	4790	7422	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Vascular_endothelial_growth_factor signalling in endothelial cell survival : a role for NFkappaB .
12882972	0	NFkappaB	0,8	apolipoprotein_A-I	26,44	NFkappaB	apolipoprotein A-I	18033(Tax:10090)	11806(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	NFkappaB regulates plasma apolipoprotein_A-I and high density lipoprotein cholesterol through inhibition of peroxisome_proliferator-activated_receptor_alpha .
12349897	0	NFkappaB	149,157	cyclooxygenase-2	106,122	NFkappaB	cyclooxygenase-2	4790	5743	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
10995388	0	NFkappaB	37,45	glucocorticoid_receptor	4,27	NFkappaB	glucocorticoid receptor	4790	2908	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The glucocorticoid_receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain .
15879558	0	NFkappaB	57,65	glucocorticoid_receptor	4,27	NFkappaB	glucocorticoid receptor	4790	2908	Gene	Gene	blocks|nmod|START_ENTITY blocks|nsubj|END_ENTITY	The glucocorticoid_receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression .
9681388	0	NFkappaB	86,94	interleukin-1_beta	53,71	NFkappaB	interleukin-1 beta	18033(Tax:10090)	16176(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Interleukin-1-mediated febrile responses in mice and interleukin-1_beta activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1_receptor_accessory_protein .
16455661	0	NFkappaB	70,78	interleukin-1beta	11,28	NFkappaB	interleukin-1beta	4790	3553	Gene	Gene	activation|nmod|START_ENTITY causes|dobj|activation causes|nsubj|signaling signaling|amod|END_ENTITY	Persistent interleukin-1beta signaling causes long term activation of NFkappaB in a promoter-specific manner in human glial cells .
19801678	0	NFkappaB	91,99	interleukin-1beta	38,55	NFkappaB	interleukin-1beta	4790	3553	Gene	Gene	activation|nmod|START_ENTITY IL-1beta|dep|activation IL-1beta|amod|END_ENTITY	Lipid rafts and caveolin-1 coordinate interleukin-1beta -LRB- IL-1beta -RRB- - dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane .
20360864	0	NFkappaB	86,94	matrix_metalloproteinase-3	30,56	NFkappaB	matrix metalloproteinase-3	4790	4314	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Allele-specific regulation of matrix_metalloproteinase-3 gene by transcription factor NFkappaB .
16648633	0	NFkappaB	97,105	matrix_metalloproteinase_13	35,62	NFkappaB	matrix metalloproteinase 13	4790	4322	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase END_ENTITY|nmod|activation	Hyaluronan oligosaccharides induce matrix_metalloproteinase_13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes .
15743683	0	NFkappaB	37,45	nuclear_factor-kappaB	14,35	NFkappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of nuclear_factor-kappaB -LRB- NFkappaB -RRB- identifies a high-risk subset of hormone-dependent breast_cancers .
14611907	0	NFkappaB	60,68	nuclear_factor-kappa_B	36,58	NFkappaB	nuclear factor-kappa B	4790	4790	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	A flow cytometry technique to study nuclear_factor-kappa_B -LRB- NFkappaB -RRB- translocation during human B_cell_activation .
16328384	0	NFkappaB	38,46	nuclear_factor_kappa_B	14,36	NFkappaB	nuclear factor kappa B	4790	4790	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of nuclear_factor_kappa_B -LRB- NFkappaB -RRB- activity in oral_tumor cells prevents depletion of NK cells and increases their functional activation .
16244358	0	NFkappaB	144,152	p53	118,121	NFkappaB	p53	18033(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY phosphorylation|nmod|activation phosphorylation|nmod|END_ENTITY	Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation : role of p38 MAP kinase .
19112107	0	NFkappaB	148,156	vascular_endothelial_growth_factor	21,55	NFkappaB	vascular endothelial growth factor	4790	7422	Gene	Gene	CBM|compound|START_ENTITY complex|nsubj|CBM activating|xcomp|complex stimulates|advcl|activating stimulates|dobj|expression expression|amod|END_ENTITY	CXCL8/IL8 stimulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM -LRB- Carma3/Bcl10/Malt1 -RRB- complex .
11491660	0	NFkappaB-inducing_kinase	76,100	NFkappaB	28,36	NFkappaB-inducing kinase	NFkappaB	9020	4790	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	Hydrogen_peroxide activates NFkappaB and the interleukin-6 promoter through NFkappaB-inducing_kinase .
14501219	0	NG2	28,31	AN2	0,3	NG2	AN2	121021(Tax:10090)	121021(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	AN2 , the mouse homologue of NG2 , is a surface antigen on glial precursor cells implicated in control of cell migration .
19489104	0	NG2	95,98	EGFR	89,93	NG2	EGFR	1464	1956	Gene	Gene	cells|dep|START_ENTITY cells|compound|END_ENTITY	Analysis of stem cell lineage progression in the neonatal subventricular zone identifies EGFR + / NG2 - cells as transit-amplifying precursors .
21956849	0	NG2	22,25	GPR17	4,9	NG2	GPR17	1464	2840	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The GPR17 receptor in NG2 expressing cells : focus on in vivo cell maturation and participation in acute trauma and chronic damage .
10967549	0	NG2	98,101	MUPP1	29,34	NG2	MUPP1	1464	8777	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2 .
14657171	0	NG2	90,93	Matrix_metalloproteinase-9	0,26	NG2	Matrix metalloproteinase-9	121021(Tax:10090)	17395(Tax:10090)	Gene	Gene	proteoglycan|compound|START_ENTITY processing|dobj|proteoglycan facilitates|advcl|processing facilitates|nsubj|END_ENTITY	Matrix_metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan .
21756907	0	NG2	53,56	Matrix_metalloproteinase-9	0,26	NG2	Matrix metalloproteinase-9	1464	4318	Gene	Gene	cells|compound|START_ENTITY proliferation|nmod|cells controls|dobj|proliferation controls|nsubj|END_ENTITY	Matrix_metalloproteinase-9 controls proliferation of NG2 + progenitor cells immediately after spinal_cord_injury .
25285951	0	NG2	55,58	NG2	90,93	NG2	NG2	1464	1464	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|END_ENTITY	Pro-Inflammatory Cytokines Reduce the Proliferation of NG2 Cells and Increase Shedding of NG2 In Vivo and In Vitro .
25285951	0	NG2	90,93	NG2	55,58	NG2	NG2	1464	1464	Gene	Gene	Cells|nmod|START_ENTITY Cells|compound|END_ENTITY	Pro-Inflammatory Cytokines Reduce the Proliferation of NG2 Cells and Increase Shedding of NG2 In Vivo and In Vitro .
23160237	0	NG2	24,27	PDGFR-a	28,35	NG2	PDGFR-a	121021(Tax:10090)	18595(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Abnormal development of NG2 + PDGFR-a + neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model .
26437238	0	NG2	49,52	Stonin1	0,7	NG2	Stonin1	121021(Tax:10090)	77057(Tax:10090)	Gene	Gene	endocytosis|nmod|START_ENTITY mediates|dobj|endocytosis mediates|nsubj|END_ENTITY	Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility .
24918635	0	NG2	106,109	matrix_metalloproteinase-9	15,41	NG2	matrix metalloproteinase-9	1464	4318	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in amyloid-b 1-42-induced shedding of the pericyte proteoglycan NG2 .
21403867	0	NGAL	30,34	IL-1b	5,10	NGAL	IL-1b	3934	3553	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Both IL-1b and TNF-a regulate NGAL expression in polymorphonuclear granulocytes of chronic hemodialysis patients .
26622883	0	NGAL	59,63	MMP-2	14,19	NGAL	MMP-2	3934	4313	Gene	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of MMP-2 , MMP-9 , TIMP-1 , TIMP-2 , NGAL and MMP-9 / NGAL complex in urine and sera from patients with bladder_cancer .
23478276	0	NGAL	14,18	MMP-9	8,13	NGAL	MMP-9	3934	4318	Gene	Gene	ratio|amod|START_ENTITY ratio|dep|END_ENTITY	Urinary MMP-9 / NGAL ratio as a potential marker of FSGS in nephrotic children .
26116587	0	NGAL	54,58	Neutrophil_Gelatinase-Associated_Lipocalin	10,52	NGAL	Neutrophil Gelatinase-Associated Lipocalin	3934	3934	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	Corrected Neutrophil_Gelatinase-Associated_Lipocalin -LRB- NGAL -RRB- Level Adjusted by the Scoring System of an Inflammation Index for Screening Renal Dysfunction in Patients with Systemic_Inflammation .
26303800	0	NGAL	58,62	Neutrophil_Gelatinase-Associated_Lipocalin	14,56	NGAL	Neutrophil Gelatinase-Associated Lipocalin	3934	3934	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Urine Neutrophil_Gelatinase-Associated_Lipocalin -LRB- NGAL -RRB- in the Early Diagnosis of Amphotericin_B-induced Acute_Kidney_Injury .
26303800	0	NGAL	58,62	Neutrophil_Gelatinase-Associated_Lipocalin	14,56	NGAL	Neutrophil Gelatinase-Associated Lipocalin	3934	3934	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Urine Neutrophil_Gelatinase-Associated_Lipocalin -LRB- NGAL -RRB- in the Early Diagnosis of Amphotericin_B-induced Acute_Kidney_Injury .
22418433	0	NGAL	44,48	Neutrophil_gelatinase-associated_lipocalin	0,42	NGAL	Neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1 .
12600287	0	NGAL	134,138	neutrophil_gelatinase-associated_lipocalin	90,132	NGAL	neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Cloning and identification of 5 ' - untranslated region -LRB- UTR -RRB- and 3 ' - untranslated region of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- gene from esophageal_carcinoma cell line SHEEC -RSB- .
20406131	0	NGAL	75,79	neutrophil_gelatinase-associated_lipocalin	31,73	NGAL	neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Clinical implication of plasma neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- concentrations in patients with advanced carotid_atherosclerosis .
21421891	0	NGAL	81,85	neutrophil_gelatinase-associated_lipocalin	37,79	NGAL	neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intra-amniotic infection upregulates neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- expression at the maternal-fetal interface at term : implications for infection-related preterm_birth .
23114405	0	NGAL	90,94	neutrophil_gelatinase-associated_lipocalin	46,88	NGAL	neutrophil gelatinase-associated lipocalin	170496(Tax:10116)	170496(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Increased trophoblastic apoptosis mediated by neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- activation in the nitrofen model of congenital_diaphragmatic_hernia .
23439619	0	NGAL	66,70	neutrophil_gelatinase-associated_lipocalin	22,64	NGAL	neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Circulating levels of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- correlate with the presence and severity of preeclampsia .
23627612	0	NGAL	66,70	neutrophil_gelatinase-associated_lipocalin	22,64	NGAL	neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of plasma neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- with sepsis and acute kidney_dysfunction .
23760084	0	NGAL	124,128	neutrophil_gelatinase-associated_lipocalin	14,56	NGAL	neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- , matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and their complex MMP-9 / NGAL in sera and urine of patients with kidney_tumors .
24697112	0	NGAL	56,60	neutrophil_gelatinase-associated_lipocalin	12,54	NGAL	neutrophil gelatinase-associated lipocalin	3934	3934	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- in cerebrospinal fluids for screening of acute bacterial_meningitis .
27087673	0	NGAL	58,62	neutrophil_gelatinase-associated_lipocalin	14,56	NGAL	neutrophil gelatinase-associated lipocalin	170496(Tax:10116)	170496(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- in peripheral nerve repair .
22962218	0	NGAL	75,79	neutrophil_gelatinase_associated_lipocalin	31,73	NGAL	neutrophil gelatinase associated lipocalin	3934	3934	Gene	Gene	Variation|appos|START_ENTITY Variation|nmod|END_ENTITY	Variation of serum and urinary neutrophil_gelatinase_associated_lipocalin -LRB- NGAL -RRB- after strenuous physical exercise .
24395189	0	NGAL	61,65	neutrophil_gelatinase_associated_lipocalin	17,59	NGAL	neutrophil gelatinase associated lipocalin	3934	3934	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum and plasma neutrophil_gelatinase_associated_lipocalin -LRB- NGAL -RRB- levels are not equivalent in patients admitted to intensive care .
25778333	0	NGAL	84,88	neutrophil_gelatinase_associated_lipocalin	40,82	NGAL	neutrophil gelatinase associated lipocalin	3934	3934	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The effect of anaesthetic management on neutrophil_gelatinase_associated_lipocalin -LRB- NGAL -RRB- levels after robotic surgical oncology .
10698011	0	NGF	108,111	BDNF	152,156	NGF	BDNF	310738(Tax:10116)	24225(Tax:10116)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	GABA -LRB- B -RRB- receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve_growth_factor -LRB- NGF -RRB- and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- in brain and spinal cord of rats .
10817624	0	NGF	120,123	BDNF	89,93	NGF	BDNF	4803	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Mapping the differences in the brain concentration of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- in an animal model of depression .
15169782	0	NGF	103,106	BDNF	72,76	NGF	BDNF	4803	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Paracrine and autocrine functions of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- in brain-derived endothelial cells .
25314897	0	NGF	113,116	BDNF	82,86	NGF	BDNF	310738(Tax:10116)	24225(Tax:10116)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	The exposure to nicotine affects expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- in neonate rats .
8366347	0	NGF	92,95	BDNF	61,65	NGF	BDNF	310738(Tax:10116)	24225(Tax:10116)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Cholinergic regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- mRNA levels in the developing rat hippocampus .
9299533	0	NGF	108,111	BDNF	77,81	NGF	BDNF	18049(Tax:10090)	12064(Tax:10090)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Dopaminergic transmitter up-regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- synthesis in mouse astrocytes in culture .
8025241	0	NGF	20,23	CNTF	0,4	NGF	CNTF	310738(Tax:10116)	25707(Tax:10116)	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	CNTF is superior to NGF as a survival enhancement factor for adrenal medulla cells in vitro .
6972865	0	NGF	78,81	EGF	112,115	NGF	EGF	18049(Tax:10090)	13645(Tax:10090)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	Effect of thyroxine , testosterone , and corticosterone on nerve_growth_factor -LRB- NGF -RRB- and epidermal_growth_factor -LRB- EGF -RRB- concentrations in adult female mouse submaxillary gland : dissociation of NGF and EGF responses .
14686749	0	NGF	40,43	GDNF	45,49	NGF	GDNF	4803	2668	Gene	Gene	IL-6|compound|START_ENTITY IL-6|appos|END_ENTITY	Pain-related differential expression of NGF , GDNF , IL-6 , and their receptors in human vasculitic_neuropathies .
14622124	0	NGF	0,3	GSK3beta	46,54	NGF	GSK3beta	310738(Tax:10116)	84027(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
8808283	0	NGF	75,78	NGFB	85,89	NGF	NGFB	4803	4803	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Integrated physical , genetic , and genic map covering 3 Mb around the human NGF gene -LRB- NGFB -RRB- at 1p13 .
12106348	0	NGF	48,51	Nerve_Growth_Factor	27,46	NGF	Nerve Growth Factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Differential Regulation of Nerve_Growth_Factor -LRB- NGF -RRB- Synthesis in Neurons and Astrocytes by Glucocorticoid Hormones .
9291146	0	NGF	21,24	Nerve_growth_factor	0,19	NGF	Nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nerve_growth_factor -LRB- NGF -RRB- expression in rat microglia is induced by adenosine_A2a-receptors .
11007890	0	NGF	0,3	TrkA	20,24	NGF	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking .
14622124	0	NGF	0,3	TrkA	67,71	NGF	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|GSK3beta GSK3beta|nmod|receptor receptor|compound|END_ENTITY	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
14663198	0	NGF	81,84	TrkA	52,56	NGF	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY impairs|nmod|nerve_growth_factor impairs|dobj|response response|nmod|END_ENTITY	Loss of cell adhesion impairs the early response of TrkA to nerve_growth_factor -LRB- NGF -RRB- .
15051797	0	NGF	50,53	TrkA	226,230	NGF	TrkA	4803	4914	Gene	Gene	nerve_growth_factor|appos|START_ENTITY activity|nmod|nerve_growth_factor antagonist|nsubj|activity antagonist|parataxis|-4,9 -4,9|dep|-RSB- -RSB-|acl:relcl|suggests suggests|nmod|presence presence|nmod|END_ENTITY	Differential activity of the nerve_growth_factor -LRB- NGF -RRB- antagonist PD90780 -LSB- 7 - -LRB- benzolylamino -RRB- -4,9 - dihydro-4-methyl-9-oxo-pyrazolo -LSB- 5,1-b -RSB- quinazoline-2-carboxylic acid -RSB- suggests altered NGF-p75NTR interactions in the presence of TrkA .
15955426	0	NGF	5,8	TrkA	0,4	NGF	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	TrkA NGF receptor plays a role in the modulation of p75NTR expression .
16644033	0	NGF	57,60	TrkA	72,76	NGF	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|dep|END_ENTITY	Glucose regulates expression of the nerve_growth_factor -LRB- NGF -RRB- receptors TrkA and p75NTR in rat islets and INS-1E beta-cells .
20708239	0	NGF	34,37	TrkA	66,70	NGF	TrkA	281350(Tax:9913)	353111(Tax:9913)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	Detection of nerve_growth_factor -LRB- NGF -RRB- and its specific receptor -LRB- TrkA -RRB- in ejaculated bovine sperm , and the effects of NGF on sperm function .
25644424	0	NGF	66,69	TrkA	103,107	NGF	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	The effect of mild stress stimulation on the nerve_growth_factor -LRB- NGF -RRB- and tyrosine_kinase_receptor_A -LRB- TrkA -RRB- immunoreactivity in the paraventricular nucleus -LRB- PVN -RRB- of the hypothalamus and hippocampus in aged vs. adult rats .
10198817	0	NGF	8,11	c-Jun	31,36	NGF	c-Jun	4803	3725	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of NGF in axotomy-induced c-Jun expression in medial septal cholinergic neurons .
61795	0	NGF	33,36	nerve-growth_factor	12,31	NGF	nerve-growth factor	4803	4803	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of nerve-growth_factor -LRB- NGF -RRB- in the central nervous system .
1217903	0	NGF	35,38	nerve_growth_factor	14,33	NGF	nerve growth factor	4803	4803	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of nerve_growth_factor -LRB- NGF -RRB- on formation of synapses in newt embryonic neural tube -RSB- .
1376870	0	NGF	34,37	nerve_growth_factor	13,32	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction by nerve_growth_factor -LRB- NGF -RRB- of NGF_receptor-like immunoreactivity in the preoptic area and hypothalamus of neonatal rats .
14614283	0	NGF	45,48	nerve_growth_factor	24,43	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Angiogenesis effects of nerve_growth_factor -LRB- NGF -RRB- on rat corneas .
1648856	0	NGF	41,44	nerve_growth_factor	20,39	NGF	nerve growth factor	4803	4803	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Temporal pattern of nerve_growth_factor -LRB- NGF -RRB- binding in vivo and the in vitro effects of NGF on cultures of developing auditory and vestibular neurons .
16520000	0	NGF	52,55	nerve_growth_factor	31,50	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|dep|END_ENTITY	Regulation of PrPC expression : nerve_growth_factor -LRB- NGF -RRB- activates the prion gene promoter through the MEK1 pathway in PC12 cells .
16928414	0	NGF	43,46	nerve_growth_factor	22,41	NGF	nerve growth factor	4803	4803	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The potential role of nerve_growth_factor -LRB- NGF -RRB- in painful_neuromas and the mechanism of pain relief by their relocation to muscle .
17096853	0	NGF	32,35	nerve_growth_factor	11,30	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of nerve_growth_factor -LRB- NGF -RRB- on blood vessels area and expression of the angiogenic factors VEGF and TGFbeta1 in the rat ovary .
18329889	0	NGF	66,69	nerve_growth_factor	45,64	NGF	nerve growth factor	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Ganglioside_GM1 effects on the expression of nerve_growth_factor -LRB- NGF -RRB- , Trk-A receptor , proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic -LRB- NOD -RRB- mice .
18922683	0	NGF	46,49	nerve_growth_factor	25,44	NGF	nerve growth factor	4803	4803	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Quantitative analysis of nerve_growth_factor -LRB- NGF -RRB- in the atopic_dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic_dermatitis .
19834819	0	NGF	31,34	nerve_growth_factor	10,29	NGF	nerve growth factor	103350089	103350089	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of nerve_growth_factor -LRB- NGF -RRB- on the development of preimplantation rabbit embryos in vitro .
209849	0	NGF	69,72	nerve_growth_factor	48,67	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the retrograde transport of nerve_growth_factor -LRB- NGF -RRB- using high specific activity -LSB- 125I -RSB- NGF .
2142224	0	NGF	42,45	nerve_growth_factor	21,40	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Endogenous levels of nerve_growth_factor -LRB- NGF -RRB- are altered in experimental diabetes_mellitus : a possible role for NGF in the pathogenesis of diabetic_neuropathy .
21526490	0	NGF	52,55	nerve_growth_factor	31,50	NGF	nerve growth factor	102536531	102536531	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of nerve_growth_factor -LRB- NGF -RRB- in the testis of alpaca -LRB- llama pacos -RRB- .
21541365	0	NGF	72,75	nerve_growth_factor	51,70	NGF	nerve growth factor	4803	4803	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Neurosteroid dehydroepiandrosterone interacts with nerve_growth_factor -LRB- NGF -RRB- receptors , preventing neuronal_apoptosis .
22138126	0	NGF	37,40	nerve_growth_factor	16,35	NGF	nerve growth factor	4803	4803	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Localization of nerve_growth_factor -LRB- NGF -RRB- receptors in the mitochondrial compartment : characterization and putative role .
22293692	0	NGF	35,38	nerve_growth_factor	14,33	NGF	nerve growth factor	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of nerve_growth_factor -LRB- NGF -RRB- on distribution of perivascular nerves in tumor neovasculatures of mouse corneal -RSB- .
22526467	0	NGF	83,86	nerve_growth_factor	62,81	NGF	nerve growth factor	4803	4803	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human neural stem cells genetically modified to express human nerve_growth_factor -LRB- NGF -RRB- gene restore cognition in the mouse with ibotenic_acid-induced cognitive_dysfunction .
2318311	0	NGF	91,94	nerve_growth_factor	70,89	NGF	nerve growth factor	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phorbol_12-myristate_13-acetate -LRB- PMA -RRB- increases the expression of the nerve_growth_factor -LRB- NGF -RRB- gene in mouse L-929 fibroblasts .
23696568	0	NGF	142,145	nerve_growth_factor	121,140	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Differential effects of dehydroepiandrosterone and testosterone in prostate and colon_cancer cell apoptosis : the role of nerve_growth_factor -LRB- NGF -RRB- receptors .
24361544	0	NGF	27,30	nerve_growth_factor	6,25	NGF	nerve growth factor	4803	4803	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Serum nerve_growth_factor -LRB- NGF -RRB- levels in children with attention_deficit / hyperactivity_disorder -LRB- ADHD -RRB- .
26021968	0	NGF	82,85	nerve_growth_factor	61,80	NGF	nerve growth factor	4803	4803	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Harm avoidance involved in mediating the association between nerve_growth_factor -LRB- NGF -RRB- gene polymorphisms and antidepressant efficacy in patients with major_depressive_disorder .
26021968	0	NGF	82,85	nerve_growth_factor	61,80	NGF	nerve growth factor	4803	4803	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Harm avoidance involved in mediating the association between nerve_growth_factor -LRB- NGF -RRB- gene polymorphisms and antidepressant efficacy in patients with major_depressive_disorder .
26118751	0	NGF	37,40	nerve_growth_factor	16,35	NGF	nerve growth factor	4803	4803	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of nerve_growth_factor -LRB- NGF -RRB- in patients with major_depression_disorder and suicide risk .
3384176	0	NGF	38,41	nerve_growth_factor	17,36	NGF	nerve growth factor	396466(Tax:9031)	396466(Tax:9031)	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	The synthesis of nerve_growth_factor -LRB- NGF -RRB- in developing skin is independent of innervation .
4134529	0	NGF	35,38	nerve_growth_factor	14,33	NGF	nerve growth factor	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of nerve_growth_factor -LRB- NGF -RRB- upon axoplasmic transport in sympathetic neurons of the mouse .
4211021	0	NGF	41,44	nerve_growth_factor	20,39	NGF	nerve growth factor	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Specific binding of nerve_growth_factor -LRB- NGF -RRB- by murine C 1300 neuroblastoma cells .
4937105	0	NGF	36,39	nerve_growth_factor	15,34	NGF	nerve growth factor	4803	4803	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of the nerve_growth_factor -LRB- NGF -RRB- on cell cultures of the trigeminal ganglion -RSB- .
5639608	0	NGF	72,75	nerve_growth_factor	51,70	NGF	nerve growth factor	4803	4803	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Glucose metabolism in embryonic ganglia : effect of nerve_growth_factor -LSB- NGF -RSB- and insulin .
58700	0	NGF	119,122	nerve_growth_factor	98,117	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	accumulation|appos|START_ENTITY accumulation|nmod|END_ENTITY	The significance of retrograde axonal transport for the accumulation of systemically administered nerve_growth_factor -LRB- NGF -RRB- in the rat superior cervical ganglion .
6383859	0	NGF	35,38	nerve_growth_factor	14,33	NGF	nerve growth factor	4803	4803	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of nerve_growth_factor -LRB- NGF -RRB- on the catecholamine contents of two human pheochromocytomas in tissue culture .
7473570	0	NGF	100,103	nerve_growth_factor	50,69	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
7985814	0	NGF	46,49	nerve_growth_factor	25,44	NGF	nerve growth factor	4803	4803	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Developmental changes in nerve_growth_factor -LRB- NGF -RRB- binding and NGF receptor proteins trkA and p75 in the facial nerve .
8028775	0	NGF	41,44	nerve_growth_factor	20,39	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Increased levels of nerve_growth_factor -LRB- NGF -RRB- protein and mRNA and reactive gliosis following kainic_acid injection into the rat striatum .
8459651	0	NGF	32,35	nerve_growth_factor	11,30	NGF	nerve growth factor	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of nerve_growth_factor -LRB- NGF -RRB- in rats with basal forebrain lesions .
9211449	0	NGF	94,97	nerve_growth_factor	73,92	NGF	nerve growth factor	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- A sensitive two-site -LRB- sandwich -RRB- enzyme immunoassay system for measuring nerve_growth_factor -LRB- NGF -RRB- -RSB- .
949726	0	NGF	56,59	nerve_growth_factor	35,54	NGF	nerve growth factor	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of nerve_growth_factor -LRB- NGF -RRB- in the submandibular gland of adult mice by light and electron microscopy .
1764245	0	NGF	0,3	p21ras	29,35	NGF	p21ras	310738(Tax:10116)	293621(Tax:10116)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	NGF and EGF rapidly activate p21ras in PC12 cells by distinct , convergent pathways involving tyrosine phosphorylation .
7473570	0	NGF	100,103	p75	96,99	NGF	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
7473570	0	NGF	71,74	p75	96,99	NGF	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|nmod|receptor receptor|amod|END_ENTITY	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
9622009	0	NGF	68,71	p75	9,12	NGF	p75	18049(Tax:10090)	18053(Tax:10090)	Gene	Gene	level|compound|START_ENTITY modulated|nmod|level modulated|nsubjpass|Level Level|nmod|expression expression|amod|END_ENTITY	Level of p75 receptor expression in sensory ganglia is modulated by NGF level in the target tissue .
11859925	0	NGF	49,52	trkA	18,22	NGF	trkA	4803	4914	Gene	Gene	binding|amod|START_ENTITY exhibiting|dobj|binding mutant|xcomp|exhibiting mutant|nsubj|END_ENTITY	A double cysteine trkA mutant exhibiting reduced NGF binding and delayed Erk signaling .
7985814	0	NGF	46,49	trkA	85,89	NGF	trkA	4803	4914	Gene	Gene	changes|appos|START_ENTITY binding|nsubj|changes binding|dobj|proteins proteins|amod|END_ENTITY	Developmental changes in nerve_growth_factor -LRB- NGF -RRB- binding and NGF receptor proteins trkA and p75 in the facial nerve .
8112464	0	NGF1-A	22,28	retinal_degeneration_slow	37,62	NGF1-A	retinal degeneration slow	13653(Tax:10090)	19133(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Diurnal expression of NGF1-A mRNA in retinal_degeneration_slow -LRB- rds -RRB- mutant mouse retina .
8808283	0	NGFB	85,89	NGF	75,78	NGFB	NGF	4803	4803	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Integrated physical , genetic , and genic map covering 3 Mb around the human NGF gene -LRB- NGFB -RRB- at 1p13 .
2906326	0	NGFB	79,83	TSHB	118,122	NGFB	TSHB	4803	7252	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Two thyroid hormone regulated genes , the beta-subunits of nerve growth factor -LRB- NGFB -RRB- and thyroid stimulating hormone -LRB- TSHB -RRB- , are located less than 310 kb apart in both human and mouse genomes .
10640682	0	NGFI-A	14,20	Egr-1	22,27	NGFI-A	Egr-1	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of NGFI-A -LRB- Egr-1 -RRB- gene expression by the POU domain transcription factor Brn-3a .
9418898	0	NGFI-A	23,29	Nab1	0,4	NGFI-A	Nab1	1958	4664	Gene	Gene	corepressor|nmod|START_ENTITY END_ENTITY|appos|corepressor	Nab1 , a corepressor of NGFI-A -LRB- Egr-1 -RRB- , contains an active transcriptional repression domain .
12031344	0	NGFI-A	65,71	ZIF268	57,63	NGFI-A	ZIF268	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Anatomical and temporal differences in the regulation of ZIF268 -LRB- NGFI-A -RRB- protein in the hamster and mouse suprachiasmatic nucleus .
10849212	0	NGFI-A	29,35	egr-1	23,28	NGFI-A	egr-1	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Cyclical expression of egr-1 / NGFI-A in the rat anterior pituitary : a molecular signal for ovulation ?
15501594	0	NGFI-A	83,89	nerve_growth_factor-induced_gene_A	47,81	NGFI-A	nerve growth factor-induced gene A	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Postnatal expression of the plasticity-related nerve_growth_factor-induced_gene_A -LRB- NGFI-A -RRB- protein in the superficial layers of the rat superior colliculus : relation to N-methyl-D-aspartate receptor function .
1613551	0	NGFI-A	22,28	zif268	30,36	NGFI-A	zif268	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Dynamic regulation of NGFI-A -LRB- zif268 , egr1 -RRB- gene expression in the striatum .
9191106	0	NGFI-A	51,57	zif268	43,49	NGFI-A	zif268	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Visual sensitivities of nur77 -LRB- NGFI-B -RRB- and zif268 -LRB- NGFI-A -RRB- induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses .
8895335	0	NGFI-B	49,55	nerve_growth_factor-induced_gene-B	13,47	NGFI-B	nerve growth factor-induced gene-B	403897(Tax:9615)	403897(Tax:9615)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of nerve_growth_factor-induced_gene-B -LRB- NGFI-B -RRB- as an early event in the cyclic_adenosine_monophosphate response of dog thyrocytes in primary culture .
8380897	0	NGFI-B	28,34	steroid_21-hydroxylase	77,99	NGFI-B	steroid 21-hydroxylase	15370(Tax:10090)	13079(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid_21-hydroxylase .
1324502	0	NGFR	65,69	nerve_growth_factor_receptor	35,63	NGFR	nerve growth factor receptor	4804	4804	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of nerve_growth_factor_receptor -LRB- NGFR -RRB- in human teeth .
1846159	0	NGFR	59,63	nerve_growth_factor_receptor	29,57	NGFR	nerve growth factor receptor	24596(Tax:10116)	24596(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Non-radioactive detection of nerve_growth_factor_receptor -LRB- NGFR -RRB- mRNA in rat brain using in situ hybridization histochemistry .
26278479	0	NGFR	71,75	nerve_growth_factor_receptor	41,69	NGFR	nerve growth factor receptor	4804	4804	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Functional Ser205Leu polymorphism of the nerve_growth_factor_receptor -LRB- NGFR -RRB- gene is associated with vagal autonomic dysregulation in humans .
26278479	0	NGFR	71,75	nerve_growth_factor_receptor	41,69	NGFR	nerve growth factor receptor	4804	4804	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Functional Ser205Leu polymorphism of the nerve_growth_factor_receptor -LRB- NGFR -RRB- gene is associated with vagal autonomic dysregulation in humans .
19041213	0	NGFR	47,51	p75	43,46	NGFR	p75	4804	11168	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Patterns of expression and function of the p75 -LRB- NGFR -RRB- protein in pancreatic_cancer cells and tumours .
21178583	0	NGFR	0,4	p75	6,9	NGFR	p75	4804	7133	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	NGFR -LRB- p75 -RRB- expression in cutaneous scars ; Further evidence for a potential pitfall in evaluation of reexcision scars of cutaneous neoplasms , in particular desmoplastic_melanoma .
1666130	0	NGF_receptor	31,43	CNTF	10,14	NGF receptor	CNTF	24596(Tax:10116)	25707(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of CNTF on low-affinity NGF_receptor expression by cultured neurons from different rat brain regions .
9605523	0	NGF_receptor	25,37	p75	39,42	NGF receptor	p75	4804	3560	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the low-affinity NGF_receptor -LRB- p75 -RRB- in survival of retinal bipolar cells .
19499154	0	NGX6	0,4	AP-1	14,18	NGX6	AP-1	51754	2353	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin_D1 in human colorectal_cancer .
17270023	0	NGX6	56,60	ezrin	18,23	NGX6	ezrin	51754	7430	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of ezrin in NPC and its interaction with NGX6 , a novel candidate suppressor .
7548147	0	NHE-1	154,159	NHE-2	125,130	NHE-1	NHE-2	20544(Tax:10090)	226999(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The effect of lethal_acid stress on Na + / H + exchanger isoforms in cultured inner medullary collecting duct cells : deletion of NHE-2 and over expression of NHE-1 .
7548147	0	NHE-2	125,130	NHE-1	154,159	NHE-2	NHE-1	226999(Tax:10090)	20544(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The effect of lethal_acid stress on Na + / H + exchanger isoforms in cultured inner medullary collecting duct cells : deletion of NHE-2 and over expression of NHE-1 .
8661513	0	NHE-2	49,54	NHE-3	98,103	NHE-2	NHE-3	100101921(Tax:9823)	397358(Tax:9823)	Gene	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Transient expression of Na + / H + exchanger isoform NHE-2 in LLC-PK1 cells : inhibition of endogenous NHE-3 and regulation by hypertonicity .
8661513	0	NHE-3	98,103	NHE-2	49,54	NHE-3	NHE-2	397358(Tax:9823)	100101921(Tax:9823)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Transient expression of Na + / H + exchanger isoform NHE-2 in LLC-PK1 cells : inhibition of endogenous NHE-3 and regulation by hypertonicity .
9727362	0	NHE-3	21,26	NaPi-2	52,58	NHE-3	NaPi-2	24784(Tax:10116)	25548(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states .
10672002	0	NHE1	19,23	Insulin	0,7	NHE1	Insulin	6548	3630	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein_kinase_C zeta in human erythrocytes .
19887620	0	NHE1	14,18	PPARgamma	33,42	NHE1	PPARgamma	6548	5468	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|activation activation|compound|END_ENTITY	Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo .
20722069	0	NHE2	52,56	Tumor_necrosis_factor-a	0,23	NHE2	Tumor necrosis factor-a	6549	7124	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Tumor_necrosis_factor-a represses the expression of NHE2 through NF-kB activation in intestinal epithelial cell model , C2BBe1 .
12372791	0	NHE3	62,66	Angiotensin_II	0,14	NHE3	Angiotensin II	24784(Tax:10116)	24179(Tax:10116)	Gene	Gene	internalization|compound|START_ENTITY step|nmod|internalization prevents|dobj|step prevents|nsubj|clamp clamp|compound|END_ENTITY	Angiotensin_II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension .
12911544	0	NHE3	26,30	Angiotensin_II	0,14	NHE3	Angiotensin II	6550	183	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates NHE3 activity by exocytic insertion of the transporter : role of PI 3-kinase .
19338654	0	NHE3	56,60	Angiotensin_II	0,14	NHE3	Angiotensin II	6550	183	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Angiotensin_II directly regulates intestinal epithelial NHE3 in Caco2BBE cells .
19864301	0	NHE3	41,45	Angiotensin_II	0,14	NHE3	Angiotensin II	24784(Tax:10116)	24179(Tax:10116)	Gene	Gene	trafficking|nmod|START_ENTITY stimulates|dobj|trafficking stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates trafficking of NHE3 , NaPi2 , and associated proteins into the proximal tubule microvilli .
16824484	0	NHE3	0,4	CFTR	53,57	NHE3	CFTR	6550	1080	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions .
25480791	0	NHE3	38,42	Cyclic_GMP_Kinase_II	0,20	NHE3	Cyclic GMP Kinase II	105243(Tax:10090)	19092(Tax:10090)	Gene	Gene	Inhibits|dobj|START_ENTITY Inhibits|nsubj|END_ENTITY	Cyclic_GMP_Kinase_II -LRB- cGKII -RRB- Inhibits NHE3 by Altering Its Trafficking and Phosphorylating NHE3 at Three Required Sites : IDENTIFICATION OF A MULTIFUNCTIONAL PHOSPHORYLATION SITE .
8843705	0	NHE3	63,67	ETB	36,39	NHE3	ETB	6550	1910	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Role of tyrosine kinase pathways in ETB receptor activation of NHE3 .
16760259	0	NHE3	39,43	IFN-gamma	0,9	NHE3	IFN-gamma	6550	3458	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	IFN-gamma and TNF-alpha regulate human NHE3 gene expression by modulating the Sp family transcription factors in human intestinal epithelial cell line C2BBe1 .
10710541	0	NHE3	105,109	NHE3	29,33	NHE3	NHE3	24784(Tax:10116)	24784(Tax:10116)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	Role of Na -LRB- + -RRB- / H -LRB- + -RRB- exchanger NHE3 in nephron function : micropuncture studies with S3226 , an inhibitor of NHE3 .
10710541	0	NHE3	29,33	NHE3	105,109	NHE3	NHE3	24784(Tax:10116)	24784(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Role of Na -LRB- + -RRB- / H -LRB- + -RRB- exchanger NHE3 in nephron function : micropuncture studies with S3226 , an inhibitor of NHE3 .
10866993	0	NHE3	37,41	NHE3	69,73	NHE3	NHE3	6550	6550	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Acute regulation of Na + / H + exchanger NHE3 by parathyroid_hormone via NHE3 phosphorylation and dynamin-dependent endocytosis .
10866993	0	NHE3	69,73	NHE3	37,41	NHE3	NHE3	6550	6550	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Acute regulation of Na + / H + exchanger NHE3 by parathyroid_hormone via NHE3 phosphorylation and dynamin-dependent endocytosis .
18829453	0	NHE3	108,112	NHE3	127,131	NHE3	NHE3	6550	6550	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	IRBIT , inositol_1 ,4,5 - triphosphate -LRB- IP3 -RRB- receptor-binding protein released with IP3 , binds Na + / H + exchanger NHE3 and activates NHE3 activity in response to calcium .
18829453	0	NHE3	127,131	NHE3	108,112	NHE3	NHE3	6550	6550	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	IRBIT , inositol_1 ,4,5 - triphosphate -LRB- IP3 -RRB- receptor-binding protein released with IP3 , binds Na + / H + exchanger NHE3 and activates NHE3 activity in response to calcium .
25715704	0	NHE3	49,53	NHE3	78,82	NHE3	NHE3	6550	6550	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Nonsynonymous Single Nucleotide Polymorphisms of NHE3 Differentially Decrease NHE3 Transporter Activity .
25715704	0	NHE3	78,82	NHE3	49,53	NHE3	NHE3	6550	6550	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Nonsynonymous Single Nucleotide Polymorphisms of NHE3 Differentially Decrease NHE3 Transporter Activity .
14580213	0	NHE3	26,30	NHERF-1	37,44	NHE3	NHERF-1	6550	9368	Gene	Gene	motif|nmod|START_ENTITY binds|nsubj|motif binds|dobj|END_ENTITY	A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange .
15218020	0	NHE3	44,48	NHERF-1	95,102	NHE3	NHERF-1	105243(Tax:10090)	26941(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1 - / - renal proximal tubule cells .
24788043	0	NHE3	0,4	PKC	25,28	NHE3	PKC	6550	112476	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	NHE3 phosphorylation via PKC marks the polarity and orientation of directionally migrating cells .
26377793	0	NHE3	30,34	Per1	76,80	NHE3	Per1	105243(Tax:10090)	18626(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of NHE3 and SGLT1 by the Circadian Clock Protein Per1 in Proximal Tubule Cells .
11737601	0	NHE3	15,19	S3226	0,5	NHE3	S3226	24784(Tax:10116)	1079480(Tax:198215)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	S3226 , a novel NHE3 inhibitor , attenuates ischemia-induced acute_renal_failure in rats .
25851603	0	NHE3	76,80	Sorting_Nexin_27	0,16	NHE3	Sorting Nexin 27	6550	81609	Gene	Gene	Trafficking|nmod|START_ENTITY regulates|dobj|Trafficking regulates|nsubj|END_ENTITY	Sorting_Nexin_27 regulates basal and stimulated Brush Border Trafficking of NHE3 .
17307723	0	NHE3	44,48	Synaptotagmin_I	0,15	NHE3	Synaptotagmin I	105243(Tax:10090)	20979(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Synaptotagmin_I binds intestinal epithelial NHE3 and mediates cAMP - and Ca2 + - induced endocytosis by recruitment of AP2 and clathrin .
9690205	0	NHE3	70,74	angiotensin_II	33,47	NHE3	angiotensin II	6550	183	Gene	Gene	activation|nmod|START_ENTITY induced|dobj|activation END_ENTITY|acl|induced	Dominant negative c-Src inhibits angiotensin_II induced activation of NHE3 in OKP cells .
15086471	0	NHE3	72,76	endothelin-1	22,34	NHE3	endothelin-1	24784(Tax:10116)	24323(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3 .
10364184	0	NHE3	65,69	megalin	24,31	NHE3	megalin	6550	4036	Gene	Gene	association|dep|START_ENTITY association|nmod|END_ENTITY	Specific association of megalin and the Na + / H + exchanger isoform NHE3 in the proximal tubule .
16920332	0	NHE5	22,26	RACK1	0,5	NHE5	RACK1	6553	10399	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity .
15808917	0	NHE6	104,108	AT2	79,82	NHE6	AT2	236794(Tax:10090)	20726(Tax:10090)	Gene	Gene	formation|dep|START_ENTITY formation|nmod|END_ENTITY	Ligand-dependent complex formation between the Angiotensin_II receptor subtype AT2 and Na + / H + exchanger NHE6 in mammalian cells .
20375273	0	NHE8	44,48	Epidermal_growth_factor	0,23	NHE8	Epidermal growth factor	23315	1950	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Epidermal_growth_factor inhibits intestinal NHE8 expression via reducing its basal transcription .
21106692	0	NHE8	35,39	Somatostatin	0,12	NHE8	Somatostatin	23315	6750	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway .
16456542	0	NHERF	38,43	PTEN	0,4	NHERF	PTEN	9368	5728	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling .
20404332	0	NHERF-1	0,7	Mrp2	17,21	NHERF-1	Mrp2	26941(Tax:10090)	12780(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function .
14580213	0	NHERF-1	37,44	NHE3	26,30	NHERF-1	NHE3	9368	6550	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|motif motif|nmod|END_ENTITY	A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange .
15218020	0	NHERF-1	95,102	NHE3	44,48	NHERF-1	NHE3	26941(Tax:10090)	105243(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1 - / - renal proximal tubule cells .
21134377	0	NHERF-2	21,28	MAGI-3	0,6	NHERF-2	MAGI-3	9351	260425	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon_cancer cells .
24595473	0	NHERF1	93,99	CFTR	49,53	NHERF1	CFTR	26941(Tax:10090)	12638(Tax:10090)	Gene	Gene	modification|nmod|START_ENTITY END_ENTITY|nmod|modification	Pseudomonas_aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1 .
24098448	0	NHERF1	154,160	CXCR2	108,113	NHERF1	CXCR2	9368	3579	Gene	Gene	domain|nmod|START_ENTITY revealed|nmod|domain revealed|nmod|structure structure|nmod|END_ENTITY	Structural insights into neutrophilic migration revealed by the crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1 .
24768637	0	NHERF1	25,31	CXCR2	83,88	NHERF1	CXCR2	9368	3579	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization .
23200831	0	NHERF1	20,26	GLAST	94,99	NHERF1	GLAST	9368	6507	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST .
15075202	0	NHERF1	25,31	RACK1	68,73	NHERF1	RACK1	9368	10399	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of a PDZ1 domain of NHERF1 in the binding of airway epithelial RACK1 to NHERF1 .
16922502	0	NHERF1	75,81	RACK1	42,47	NHERF1	RACK1	9368	10399	Gene	Gene	airway|dobj|START_ENTITY binds|xcomp|airway binds|nsubj|N-terminus N-terminus|nmod|repeat repeat|nmod|END_ENTITY	The N-terminus of the WD5 repeat of human RACK1 binds to airway epithelial NHERF1 .
18055461	0	NHERF1	8,14	aquaporin_9	99,110	NHERF1	aquaporin 9	9368	366	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of NHERF1 , cystic_fibrosis_transmembrane_conductance_regulator , and cAMP in the regulation of aquaporin_9 .
18784102	0	NHERF1	0,6	parathyroid_hormone	45,64	NHERF1	parathyroid hormone	9368	5741	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	NHERF1 mutations and responsiveness of renal parathyroid_hormone .
23026212	0	NHLH2	78,83	nescient_helix-loop-helix_2	49,76	NHLH2	nescient helix-loop-helix 2	4808	4808	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two single nucleotide polymorphisms in the human nescient_helix-loop-helix_2 -LRB- NHLH2 -RRB- gene reduce mRNA stability and DNA binding .
10593953	0	NHP2L1	24,30	HRad17	0,6	NHP2L1	HRad17	4809	5884	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation .
21454300	0	NIA1	97,101	nitrate_reductase	73,90	NIA1	nitrate reductase	844112(Tax:3702)	844112(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The regulatory region controlling the nitrate-responsive expression of a nitrate_reductase gene , NIA1 , in Arabidopsis .
12392556	0	NICN1	71,76	nicolin_1	55,64	NICN1	nicolin 1	84276	84276	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of the mammalian-specific nicolin_1 gene -LRB- NICN1 -RRB- encoding a nuclear 24 kDa protein .
15105416	0	NIDD	0,4	nNOS	79,83	NIDD	nNOS	363783(Tax:10116)	24598(Tax:10116)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	NIDD , a novel DHHC-containing protein , targets neuronal_nitric-oxide_synthase -LRB- nNOS -RRB- to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity .
15528996	0	NIK	45,48	IKKgamma	0,8	NIK	IKKgamma	53859(Tax:10090)	16151(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	IKKgamma inhibits activation of NF-kappaB by NIK .
11254583	0	NIK	67,70	IRAK	53,57	NIK	IRAK	9020	3654	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
11254583	0	NIK	67,70	MyD88	45,50	NIK	MyD88	9020	4615	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
20735436	0	NIK	52,55	NF-kB-inducing_kinase	29,50	NIK	NF-kB-inducing kinase	9020	9020	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic alteration of the NF-kB-inducing_kinase -LRB- NIK -RRB- gene is involved in enhanced NIK expression in basal-like breast_cancer .
11254583	0	NIK	67,70	NF-kappaB	79,88	NIK	NF-kappaB	9020	4790	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
20580552	0	NIK	27,30	NF-kappaB_inducing_kinase	0,25	NIK	NF-kappaB inducing kinase	9020	9020	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	NF-kappaB_inducing_kinase -LRB- NIK -RRB- inhibitors : identification of new scaffolds using virtual screening .
22968463	0	NIK	37,40	RelB	58,62	NIK	RelB	9020	5971	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Hodgkin_lymphoma requires stabilized NIK and constitutive RelB expression for survival .
19112492	0	NIK1	52,56	rpL10A	33,39	NIK1	rpL10A	831457(Tax:3702)	837993(Tax:3702)	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus .
19112492	0	NIK1	52,56	rpL10A	33,39	NIK1	rpL10A	831457(Tax:3702)	837993(Tax:3702)	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus .
3856258	0	NILE	78,82	nerve_growth_factor-inducible_large_external_glycoprotein	19,76	NILE	nerve growth factor-inducible large external glycoprotein	50687(Tax:10116)	50687(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the nerve_growth_factor-inducible_large_external_glycoprotein -LRB- NILE -RRB- in neurite_fasciculation in primary cultures of rat brain .
12063396	0	NIMA-related_protein_kinase_3	52,81	NEK3	88,92	NIMA-related protein kinase 3	NEK3	4752	4752	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the human NIMA-related_protein_kinase_3 gene -LRB- NEK3 -RRB- .
23665482	0	NIN	28,31	Ninein	20,26	NIN	Ninein	51199	51199	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Identification of a Ninein -LRB- NIN -RRB- mutation in a family with spondyloepimetaphyseal_dysplasia with joint_laxity -LRB- leptodactylic type -RRB- - like phenotype .
8235618	0	NINAC	59,64	calmodulin	14,24	NINAC	calmodulin	34012(Tax:7227)	36329(Tax:7227)	Gene	Gene	myosin|compound|START_ENTITY retina|nmod|myosin localization|nmod|retina localization|nsubj|Dependence Dependence|nmod|END_ENTITY	Dependence of calmodulin localization in the retina on the NINAC unconventional myosin .
26485645	0	NINL	46,50	CC2D2A	23,29	NINL	CC2D2A	22981	57545	Gene	Gene	Associates|nmod|START_ENTITY Associates|compound|END_ENTITY	The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking .
22205987	0	NIPA	54,58	Skp1	96,100	NIPA	Skp1	51530	6500	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	APC/C -LRB- Cdh1 -RRB- - mediated degradation of the F-box protein NIPA is regulated by its association with Skp1 .
15146186	0	NIPBL	53,58	Nipped-B	105,113	NIPBL	Nipped-B	25836	3355136(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Cornelia_de_Lange_syndrome is caused by mutations in NIPBL , the human homolog of Drosophila_melanogaster Nipped-B .
12749859	0	NIPK	6,10	ATF4	26,30	NIPK	ATF4	228775(Tax:10090)	11911(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mouse NIPK interacts with ATF4 and affects its transcriptional activity .
24413661	0	NIR	26,29	MDM2	81,85	NIR	MDM2	26155	4193	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2 .
1657150	0	NK-1	28,32	substance_P	6,17	NK-1	substance P	6869	6863	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Human substance_P receptor -LRB- NK-1 -RRB- : organization of the gene , chromosome localization , and functional expression of cDNA clones .
15390113	0	NK-1R	78,83	Interleukin-1beta	0,17	NK-1R	Interleukin-1beta	6869	3553	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-1beta upregulates functional expression of neurokinin-1_receptor -LRB- NK-1R -RRB- via NF-kappaB in astrocytes .
17392578	0	NK-1R	30,35	LIF	0,3	NK-1R	LIF	6869	3976	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	LIF upregulates expression of NK-1R in NHBE cells .
11966980	0	NK-1_receptor	95,108	Substance_P	11,22	NK-1 receptor	Substance P	6869	6863	Gene	Gene	agonist|nmod|START_ENTITY C-terminus|acl:relcl|agonist modified|nmod|C-terminus modified|nsubj|Analogs Analogs|nmod|END_ENTITY	Analogs of Substance_P modified at the C-terminus which are both agonist and antagonist of the NK-1_receptor depending on the second messenger pathway .
19076365	0	NK-1_receptor	35,48	Substance_P	0,11	NK-1 receptor	Substance P	6869	6863	Gene	Gene	interacts|compound|START_ENTITY END_ENTITY|dep|interacts	Substance_P in stress and anxiety : NK-1_receptor antagonism interacts with key brain areas of the stress circuitry .
23996004	0	NK-1_receptor	71,84	Substance_P	0,11	NK-1 receptor	Substance P	6869	6863	Gene	Gene	stimulation|compound|START_ENTITY reduces|nmod|stimulation reduces|nsubj|END_ENTITY	Substance_P reduces TNF-a-induced apoptosis in human tenocytes through NK-1_receptor stimulation .
11352645	0	NK-1_receptor	48,61	substance_P	23,34	NK-1 receptor	substance P	6869	6863	Gene	Gene	analogues|nmod|START_ENTITY analogues|compound|END_ENTITY	Internalization of -LSB- 3H -RSB- substance_P analogues in NK-1_receptor transfected CHO cells .
14635685	0	NK-1_receptor	11,24	substance_P	65,76	NK-1 receptor	substance P	21336(Tax:10090)	21333(Tax:10090)	Gene	Gene	use|nmod|START_ENTITY null|nsubj|use null|xcomp|assess assess|dobj|significance significance|nmod|END_ENTITY	The use of NK-1_receptor null mice to assess the significance of substance_P in the carotid body function .
14640725	0	NK-1_receptor	109,122	substance_P	43,54	NK-1 receptor	substance P	6869	6863	Gene	Gene	identify|nmod|START_ENTITY analogues|xcomp|identify analogues|nsubj|tags tags|nmod|END_ENTITY	Isotope and affinity tags in photoreactive substance_P analogues to identify the covalent linkage within the NK-1_receptor by MALDI-TOF analysis .
15911376	0	NK-1_receptor	97,110	substance_P	72,83	NK-1 receptor	substance P	6869	6863	Gene	Gene	bound|nmod|START_ENTITY bound|nsubj|analysis analysis|nmod|tripeptide tripeptide|nmod|END_ENTITY	Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance_P bound to the NK-1_receptor .
19528498	0	NK-1_receptor	27,40	substance_P	15,26	NK-1 receptor	substance P	6869	6863	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for the substance_P / NK-1_receptor complex in cell proliferation in oral_squamous_cell_carcinoma .
7525569	0	NK-1_receptor	48,61	substance_P	69,80	NK-1 receptor	substance P	6869	6863	Gene	Gene	II|nmod|START_ENTITY Mutations|nmod|II affect|nsubj|Mutations affect|dobj|competition competition|compound|END_ENTITY	Mutations along transmembrane segment II of the NK-1_receptor affect substance_P competition with non-peptide antagonists but not substance_P binding .
7678597	0	NK-1_receptor	94,107	substance_P	56,67	NK-1 receptor	substance P	6869	6863	Gene	Gene	role|nmod|START_ENTITY Production|dep|role Production|nmod|interleukin-1 interleukin-1|nmod|microglia microglia|nmod|response response|nmod|END_ENTITY	Production of interleukin-1 by microglia in response to substance_P : role for a non-classical NK-1_receptor .
8863485	0	NK-1_receptor	109,122	substance_P	53,64	NK-1 receptor	substance P	6869	6863	Gene	Gene	characteristics|nmod|START_ENTITY exhibit|nmod|characteristics exhibit|dobj|site site|compound|END_ENTITY	Human astrocytoma cells -LRB- U-87 MG -RRB- exhibit a specific substance_P binding site with the characteristics of an NK-1_receptor .
9022979	0	NK-1_receptor	11,24	substance_P	62,73	NK-1 receptor	substance P	6869	6863	Gene	Gene	probed|nsubj|START_ENTITY probed|nmod|analogues analogues|nmod|END_ENTITY	Tachykinin NK-1_receptor probed with constrained analogues of substance_P .
7683074	0	NK-1_receptor	42,55	substance_P_receptor	20,40	NK-1 receptor	substance P receptor	24807(Tax:10116)	24807(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of the substance_P_receptor -LRB- NK-1_receptor -RRB- in the central nervous system .
23298945	0	NK-2	97,101	P-glycoprotein	19,33	NK-2	P-glycoprotein	7080	5243	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2 : the unique way of multi-drug resistance modulation .
1333574	0	NK-2	88,92	neurokinin-A	64,76	NK-2	neurokinin-A	6863	6863	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Pharmacologic characterization of the novel ligand -LSB- 4,5-3H-Leu9 -RSB- neurokinin-A binding to NK-2 receptors on hamster_urinary_bladder_membranes .
8413330	0	NK-TR	37,42	IL-2	0,4	NK-TR	IL-2	4820	3558	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism .
8073519	0	NK1	75,78	CD3	79,82	NK1	CD3	17059(Tax:10090)	12501(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Demonstration of MHC class I-specific cytolytic activity in IL-2-activated NK1 + CD3 + cells and evidence of usage of T and NK cell receptors .
11927628	0	NK1	82,85	CD4	90,93	NK1	CD4	17059(Tax:10090)	12504(Tax:10090)	Gene	Gene	.1|compound|START_ENTITY CD1d-dependent|nummod|.1 CD1d-dependent|compound|END_ENTITY	A natural killer T -LRB- NKT -RRB- cell developmental pathway iInvolving a thymus-dependent NK1 .1 -LRB- - -RRB- CD4 -LRB- + -RRB- CD1d-dependent precursor stage .
26405570	0	NK1	20,23	CD4	100,103	NK1	CD4	11126	920	Gene	Gene	.1|compound|START_ENTITY cells|amod|.1 B220|dep|cells Depletion|nmod|B220 enhances|nsubj|Depletion enhances|dobj|rejection rejection|nmod|cells cells|amod|melanoma melanoma|nmod|T T|compound|END_ENTITY	Depletion of B220 -LRB- + -RRB- NK1 .1 -LRB- + -RRB- cells enhances the rejection of established melanoma by tumor-specific CD4 -LRB- + -RRB- T cells .
8006596	0	NK1	51,54	CD4	41,44	NK1	CD4	17059(Tax:10090)	12504(Tax:10090)	Gene	Gene	.1|compound|START_ENTITY dependence|dep|.1 dependence|nmod|development development|nmod|CD8 CD8|compound|END_ENTITY	Class I dependence of the development of CD4 + CD8 - NK1 .1 + thymocytes .
8617303	0	NK1	97,100	CD4	92,95	NK1	CD4	17059(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Selectively impaired development of intestinal T cell receptor gamma delta + cells and liver CD4 + NK1 + T cell receptor alpha beta + cells in T_cell_factor-1-deficient mice .
9138017	0	NK1	38,41	CD4	34,37	NK1	CD4	21333(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	TCR-mediated target cell lysis by CD4 + NK1 + liver T lymphocytes .
16272308	0	NK1	92,95	IL-4	53,57	NK1	IL-4	17059(Tax:10090)	16189(Tax:10090)	Gene	Gene	CD161|appos|START_ENTITY inducibility|nmod|CD161 inducibility|compound|END_ENTITY	CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161 -LRB- NK1 -RRB- - CD44lowCD4 + CD8 - T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8 / Valpha3 .2 T cell receptor usage .
8943570	0	NK1	14,17	IL-4	36,40	NK1	IL-4	17059(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	IL-7 reverses NK1 + T cell-defective IL-4 production in the non-obese_diabetic mouse .
17516061	0	NK1	83,86	KIRL1	57,62	NK1	KIRL1	17059(Tax:10090)	245616(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of murine killer immunoglobulin-like receptor KIRL1 on CD1d-independent NK1 .1 -LRB- + -RRB- T cells .
9154760	0	NK1	14,17	Neurokinin-1	0,12	NK1	Neurokinin-1	6863	6863	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Neurokinin-1 -LRB- NK1 -RRB- receptors mediate tachykinin-induced depression of GABA current in bullfrog sensory neurons .
16413782	0	NK1	73,76	neurokinin	61,71	NK1	neurokinin	6869	6869	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	1-Phenyl-8-azabicyclo -LSB- 3.2.1 -RSB- octane_ethers : a novel series of neurokinin -LRB- NK1 -RRB- antagonists .
16155744	0	NK1	50,53	neurokinin-1	36,48	NK1	neurokinin-1	6869	6869	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Visualization and quantification of neurokinin-1 -LRB- NK1 -RRB- receptors in the human brain .
16388914	0	NK1	51,54	neurokinin_1	27,39	NK1	neurokinin 1	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Expression of substance_P , neurokinin_1 receptors -LRB- NK1 -RRB- and neurokinin_3_receptors in the developing mouse retina and in the retina of NK1 knockout mice .
9622661	0	NK1	46,49	substance_P	33,44	NK1	substance P	6869	6863	Gene	Gene	localisation|appos|START_ENTITY localisation|nmod|END_ENTITY	Autoradiographic localisation of substance_P -LRB- NK1 -RRB- receptors in human primary visual cortex .
14525527	0	NK1-R	68,73	neurokinin_1_receptor	45,66	NK1-R	neurokinin 1 receptor	24807(Tax:10116)	24807(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pregnancy-induced changes in substance P and neurokinin_1_receptor -LRB- NK1-R -RRB- expression in the rat uterus .
15334646	0	NK1R	39,43	neurokinin_1_receptor	16,37	NK1R	neurokinin 1 receptor	24807(Tax:10116)	24807(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Localization of neurokinin_1_receptor -LRB- NK1R -RRB- immunoreactivity in rat esophagus .
12020057	0	NK1_receptor	55,67	substance_P	42,53	NK1 receptor	substance P	6869	6863	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Elucidating the antidepressant actions of substance_P -LRB- NK1_receptor -RRB- antagonists .
12056558	0	NK1_receptor	61,73	substance_P	48,59	NK1 receptor	substance P	21336(Tax:10090)	21333(Tax:10090)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	New insights into the antidepressant actions of substance_P -LRB- NK1_receptor -RRB- antagonists .
15023054	0	NK2	74,77	neurokinin-2	60,72	NK2	neurokinin-2	6863	6863	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Evidence for the proximity of the extreme N-terminus of the neurokinin-2 -LRB- NK2 -RRB- tachykinin receptor to Cys167 in the putative fourth transmembrane helix .
7499223	0	NK2	39,42	neurokinin-2	25,37	NK2	neurokinin-2	735077(Tax:8355)	735077(Tax:8355)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	A single mutation of the neurokinin-2 -LRB- NK2 -RRB- _ receptor prevents agonist-induced desensitization .
1665897	0	NK2_receptor	114,126	Neuropeptide_gamma	0,18	NK2 receptor	Neuropeptide gamma	6865	6863	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Neuropeptide_gamma , the most potent contractile tachykinin in human isolated bronchus , acts via a ` non-classical ' NK2_receptor .
17306250	0	NK3	19,22	nerve_growth_factor	63,82	NK3	nerve growth factor	4824	4803	Gene	Gene	receptors|compound|START_ENTITY Role|nmod|receptors Role|nmod|END_ENTITY	Role of tachykinin NK3 receptors in the release and effects of nerve_growth_factor in human isolated bronchi .
7681831	0	NK3	27,30	neurokinin_B	32,44	NK3	neurokinin B	4824	6866	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Chimeric NK1 -LRB- substance_P -RRB- / NK3 -LRB- neurokinin_B -RRB- receptors .
23656837	0	NK3_receptor	58,70	neurokinin_B	39,51	NK3 receptor	neurokinin B	6870	6866	Gene	Gene	system|amod|START_ENTITY expression|dep|system expression|nmod|END_ENTITY	Differentially regulated expression of neurokinin_B -LRB- NKB -RRB- / NK3_receptor system in uterine leiomyomata .
24311985	0	NK4	0,3	Tbx1/10	16,23	NK4	Tbx1/10	9235	6899;347853	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	NK4 antagonizes Tbx1/10 to promote cardiac versus pharyngeal muscle fate in the ascidian second heart field .
9371207	0	NKA	25,28	neurokinin_A	11,23	NKA	neurokinin A	6863	6863	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in neurokinin_A -LRB- NKA -RRB- airway responsiveness with inhaled frusemide in asthma .
16518717	0	NKB	47,50	neurokinin_B	33,45	NKB	neurokinin B	29191(Tax:10116)	29191(Tax:10116)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Membrane associated functions of neurokinin_B -LRB- NKB -RRB- on Abeta -LRB- 25-35 -RRB- induced toxicity in aging rat brain synaptosomes .
10484331	0	NKCC1	21,26	Myosin	0,6	NKCC1	Myosin	6558	79784	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Myosin regulation of NKCC1 : effects on cAMP-mediated Cl - secretion in intestinal epithelia .
9199662	0	NKCC1	64,69	Na-K-Cl_co-transporter	40,62	NKCC1	Na-K-Cl co-transporter	6558	6558	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of the Na-K-Cl_co-transporter -LRB- NKCC1 -RRB- in the gerbil inner ear .
11909643	0	NKCC1	14,19	PKC-delta_and_ERK	87,104	NKCC1	PKC-delta and ERK	6558	5580;5594	Gene	Gene	Activation|nmod|START_ENTITY involves|nsubj|Activation involves|dobj|END_ENTITY	Activation of NKCC1 by hyperosmotic stress in human tracheal epithelial cells involves PKC-delta_and_ERK .
18550547	0	NKCC1	52,57	SPAK	26,30	NKCC1	SPAK	6558	27347	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells .
20223824	0	NKCC1	88,93	SPAK	234,238	NKCC1	SPAK	100037166(Tax:8355)	446749(Tax:8355)	Gene	Gene	function|appos|START_ENTITY regulation|nmod|function phosphatase|dobj|regulation phosphatase|parataxis|serves serves|dep|END_ENTITY	Multiple pathways for protein phosphatase 1 -LRB- PP1 -RRB- regulation of Na-K-2Cl_cotransporter -LRB- NKCC1 -RRB- function : the N-terminal tail of the Na-K-2Cl_cotransporter serves as a regulatory scaffold for Ste20-related_proline / alanine-rich_kinase -LRB- SPAK -RRB- AND PP1 .
23123217	0	NKCC2	28,33	Adenylyl_cyclase_6	0,18	NKCC2	Adenylyl cyclase 6	20495(Tax:10090)	11512(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Adenylyl_cyclase_6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC .
24133122	0	NKCC2	14,19	SPAK	43,47	NKCC2	SPAK	6557	27347	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Regulation of NKCC2 activity by inhibitory SPAK isoforms : KS-SPAK is a more potent inhibitor than SPAK2 .
26902120	0	NKD2	17,21	miR-130b	0,8	NKD2	miR-130b	85409	406920	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells .
9394807	0	NKG2	39,43	NKG2-F	11,17	NKG2	NKG2-F	3821	8302	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Cloning of NKG2-F , a new member of the NKG2 family of human natural killer cell receptor genes .
10671222	0	NKG2-A	79,85	CD94	72,76	NKG2-A	CD94	3821	3824	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	CD69-triggered ERK activation and functions are negatively regulated by CD94 / NKG2-A inhibitory receptor .
9565368	0	NKG2-A	162,168	SHP-1	105,110	NKG2-A	SHP-1	29683(Tax:10116)	116689(Tax:10116)	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	Specific engagement of the CD94/NKG2-A killer inhibitory receptor by the HLA-E class Ib molecule induces SHP-1 phosphatase recruitment to tyrosine-phosphorylated NKG2-A : evidence for receptor function in heterologous transfectants .
9394807	0	NKG2-F	11,17	NKG2	39,43	NKG2-F	NKG2	8302	3821	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Cloning of NKG2-F , a new member of the NKG2 family of human natural killer cell receptor genes .
15517612	0	NKG2A	42,47	CD8	105,108	NKG2A	CD8	3821	925	Gene	Gene	receptors|compound|START_ENTITY expressed|nsubjpass|receptors expressed|nmod|subsets subsets|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
18064301	0	NKG2A	35,40	CD8	17,20	NKG2A	CD8	3821	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Small intestinal CD8 + TCRgammadelta + NKG2A + intraepithelial lymphocytes have attributes of regulatory cells in patients with celiac_disease .
18500933	0	NKG2A	87,92	CD8	93,96	NKG2A	CD8	3821	925	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Hepatitis_C virus-induced secretion of inflammatory chemokines preferentially recruits NKG2A + CD8 + T cells .
21538351	0	NKG2A	0,5	CD8	66,69	NKG2A	CD8	3821	925	Gene	Gene	marker|nsubj|START_ENTITY marker|nmod|acquisition acquisition|nmod|function function|nmod|cells cells|compound|END_ENTITY	NKG2A is a marker for acquisition of regulatory function by human CD8 + T cells activated with anti-CD3 antibody .
9034158	0	NKG2A	0,5	CD94	21,25	NKG2A	CD94	3821	3824	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor .
21346231	0	NKG2A	6,11	KLRG1	0,5	NKG2A	KLRG1	16641(Tax:10090)	50928(Tax:10090)	Gene	Gene	CD8|compound|START_ENTITY CD8|compound|END_ENTITY	KLRG1 + NKG2A + CD8 T cells mediate protection and participate in memory responses during y-herpesvirus infection .
15517612	0	NKG2A	42,47	TCR	110,113	NKG2A	TCR	3821	6962	Gene	Gene	receptors|compound|START_ENTITY expressed|nsubjpass|receptors expressed|nmod|subsets subsets|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
23396942	0	NKG2C	10,15	CD4	17,20	NKG2C	CD4	3822	920	Gene	Gene	target|compound|START_ENTITY target|compound|END_ENTITY	Cytotoxic NKG2C + CD4 T cells target oligodendrocytes in multiple_sclerosis .
26312867	0	NKG2C	78,83	KIR	84,87	NKG2C	KIR	3822	3805	Gene	Gene	population|compound|START_ENTITY population|compound|END_ENTITY	Natural killer cell maturation markers in the human liver and expansion of an NKG2C + KIR + population .
17109473	0	NKG2D	27,32	CD4	36,39	NKG2D	CD4	22914	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|cells cells|compound|END_ENTITY	Expression and function of NKG2D in CD4 + T cells specific for human_cytomegalovirus .
17570210	0	NKG2D	4,9	CD4	0,3	NKG2D	CD4	22914	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + NKG2D + T cells in Crohn 's _ disease mediate inflammatory and cytotoxic responses through MICA interactions .
17962357	0	NKG2D	12,17	CD4	63,66	NKG2D	CD4	27007(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY Blockade|nmod|signaling prevents|nsubj|Blockade prevents|dobj|development development|nmod|colitis colitis|compound|END_ENTITY	Blockade of NKG2D signaling prevents the development of murine CD4 + T cell-mediated colitis .
21210234	0	NKG2D	0,5	CD4	20,23	NKG2D	CD4	22914	920	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	NKG2D expression in CD4 + T lymphocytes as a marker of senescence in the aged immune system .
21210234	3	NKG2D	457,462	CD4	466,469	NKG2D	CD4	22914	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Typical features of cell immunosenescence are characteristics of pathologies in which the aberrant expression of NKG2D in CD4 + T cells has been described .
22384114	0	NKG2D	100,105	CD4	67,70	NKG2D	CD4	22914	920	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|cells cells|nmod|cells cells|compound|END_ENTITY	Cytotoxicity of CD56 -LRB- bright -RRB- NK cells towards autologous activated CD4 + T cells is mediated through NKG2D , LFA-1 and TRAIL and dampened via CD94/NKG2A .
22870231	0	NKG2D	44,49	CD4	88,91	NKG2D	CD4	22914	920	Gene	Gene	T-cells|nummod|START_ENTITY T-cells|compound|END_ENTITY	Regulation and gene expression profiling of NKG2D positive human_cytomegalovirus-primed CD4 + T-cells .
24282598	0	NKG2D	4,9	CD4	0,3	NKG2D	CD4	22914	920	Gene	Gene	exhibit|compound|START_ENTITY exhibit|compound|END_ENTITY	CD4 + NKG2D + T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation .
24708417	0	NKG2D	31,36	CD4	0,3	NKG2D	CD4	27007(Tax:10090)	12504(Tax:10090)	Gene	Gene	down-regulation|compound|START_ENTITY induce|dobj|down-regulation T|ccomp|induce T|nsubj|NKG2D NKG2D|compound|END_ENTITY	CD4 -LRB- + -RRB- NKG2D -LRB- + -RRB- T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1 transgenic_mice .
24761885	0	NKG2D	73,78	CD4	5,8	NKG2D	CD4	22914	920	Gene	Gene	receptors|dobj|START_ENTITY lymphocyte|ccomp|receptors lymphocyte|nsubj|+ +|compound|END_ENTITY	CD3 + CD4 + and CD3 + CD8 + lymphocyte subgroups and their surface receptors NKG2D and NKG2A in patients with non-small cell lung_cancer .
15699119	0	NKG2D	14,19	CD8	116,119	NKG2D	CD8	22914	925	Gene	Gene	Engagement|nmod|START_ENTITY insufficient|nsubj|Engagement insufficient|xcomp|mediate mediate|dobj|costimulation costimulation|nmod|cells cells|compound|END_ENTITY	Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8 + T cells .
16116168	0	NKG2D	100,105	CD8	44,47	NKG2D	CD8	27007(Tax:10090)	925	Gene	Gene	costimulation|compound|START_ENTITY similarities|nmod|costimulation Costimulation|dep|similarities Costimulation|nmod|function function|compound|END_ENTITY	Costimulation through NKG2D enhances murine CD8 + CTL function : similarities and differences between NKG2D and CD28 costimulation .
16116168	0	NKG2D	22,27	CD8	44,47	NKG2D	CD8	27007(Tax:10090)	925	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Costimulation through NKG2D enhances murine CD8 + CTL function : similarities and differences between NKG2D and CD28 costimulation .
17255258	0	NKG2D	10,15	CD8	30,33	NKG2D	CD8	22914	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cell cell|compound|END_ENTITY	Decreased NKG2D expression on CD8 + T cell is involved in immune evasion in patients with gastric_cancer .
18024793	0	NKG2D	16,21	CD8	56,59	NKG2D	CD8	22914	925	Gene	Gene	costimulation|nummod|START_ENTITY costimulation|nmod|cells cells|compound|END_ENTITY	4-1BB regulates NKG2D costimulation in human cord blood CD8 + T cells .
18564160	0	NKG2D	28,33	CD8	48,51	NKG2D	CD8	22914	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Inverse correlation between NKG2D expression on CD8 + T cells and the frequency of CD4 + CD25 + regulatory T cells in patients with esophageal_cancer .
19089424	0	NKG2D	11,16	CD8	18,21	NKG2D	CD8	22914	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	TNK cells -LRB- NKG2D + CD8 + or CD4 + T lymphocytes -RRB- in the control of human tumors .
19124832	0	NKG2D	74,79	CD8	9,12	NKG2D	CD8	22914	925	Gene	Gene	down-regulation|nmod|START_ENTITY Detuning|nmod|down-regulation Detuning|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	Detuning CD8 + T lymphocytes by down-regulation of the activating receptor NKG2D : role of NKG2D ligands released by activated T cells .
19124832	0	NKG2D	89,94	CD8	9,12	NKG2D	CD8	22914	925	Gene	Gene	ligands|nummod|START_ENTITY role|nmod|ligands role|dep|Detuning Detuning|dobj|lymphocytes lymphocytes|nummod|END_ENTITY	Detuning CD8 + T lymphocytes by down-regulation of the activating receptor NKG2D : role of NKG2D ligands released by activated T cells .
22366950	0	NKG2D	0,5	CD8	19,22	NKG2D	CD8	22914	925	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	NKG2D signaling on CD8 T cells represses T-bet and rescues CD4-unhelped CD8 T cell memory recall but not effector responses .
22640649	0	NKG2D	14,19	CD8	33,36	NKG2D	CD8	22914	925	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of NKG2D and CD107 in CD8 -LRB- + -RRB- effector memory lymphocytes in Churg-Strauss_syndrome .
22942430	0	NKG2D	23,28	CD8	58,61	NKG2D	CD8	22914	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|IL-4 IL-4|nmod|END_ENTITY	Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells .
22975165	0	NKG2D	51,56	CD8	61,64	NKG2D	CD8	22914	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Adoptive cellular therapy using cells enriched for NKG2D + CD3 + CD8 + T cells after autologous transplantation for myeloma .
23018378	0	NKG2D	0,5	CD8	33,36	NKG2D	CD8	22914	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	NKG2D expression on HIV-specific CD8 + T cells is reduced in viremic_HIV-1-infected patients but maintained in HIV controllers .
23235109	0	NKG2D	89,94	CD8	109,112	NKG2D	CD8	22914	925	Gene	Gene	gene|compound|START_ENTITY gene|nmod|T T|compound|END_ENTITY	DNA demethylation and histone H3K9 acetylation determine the active transcription of the NKG2D gene in human CD8 + T and NK cells .
23804716	0	NKG2D	0,5	CD8	56,59	NKG2D	CD8	22914	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|precursors precursors|nummod|END_ENTITY	NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase .
23922903	0	NKG2D	14,19	CD8	40,43	NKG2D	CD8	22914	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Modulation of NKG2D expression in human CD8 -LRB- + -RRB- T cells corresponding with tuberculosis drug cure .
24168855	0	NKG2D	0,5	CD8	48,51	NKG2D	CD8	22914	925	Gene	Gene	chemotaxis|amod|START_ENTITY chemotaxis|compound|END_ENTITY	NKG2D - and CD28-mediated costimulation regulate CD8 + T cell chemotaxis through different mechanisms : the role of Cdc42/N-WASp .
24586170	0	NKG2D	14,19	CD8	40,43	NKG2D	CD8	22914	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania_major_infection .
25788701	0	NKG2D	0,5	CD8	20,23	NKG2D	CD8	27007(Tax:10090)	925	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	NKG2D expression by CD8 + T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT .
26290604	0	NKG2D	59,64	CD8	65,68	NKG2D	CD8	27007(Tax:10090)	925	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Lymphocytic_Choriomeningitis Virus Expands a Population of NKG2D + CD8 + T Cells That Exacerbate Disease in Mice Coinfected with Leishmania_major .
26509932	0	NKG2D	27,32	CD8	48,51	NKG2D	CD8	22914	925	Gene	Gene	Expression|nmod|START_ENTITY Impaired|nsubjpass|Expression Impaired|nmod|Cells Cells|compound|END_ENTITY	Expression and Function of NKG2D Is Impaired in CD8 + T Cells of Chronically_HIV-1-Infected Patients Without ART .
26646698	0	NKG2D	4,9	IL-15	12,17	NKG2D	IL-15	22914	3600	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|signaling signaling|compound|END_ENTITY	The NKG2D - IL-15 signaling pathway contributes to T-cell mediated pathology in inflammatory_myopathies .
22942430	0	NKG2D	23,28	IL-4	43,47	NKG2D	IL-4	22914	3565	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Negative regulation of NKG2D expression by IL-4 in memory CD8 T cells .
11323699	0	NKG2D	51,56	MICA	89,93	NKG2D	MICA	22914	100507436	Gene	Gene	structure|nmod|START_ENTITY ligand|nsubj|structure ligand|dobj|END_ENTITY	Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA .
11491531	0	NKG2D	22,27	MICA	45,49	NKG2D	MICA	22914	100507436	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of human NKG2D with its ligands MICA , MICB , and homologs of the mouse RAE-1 protein family .
16750166	0	NKG2D	23,28	MICA	36,40	NKG2D	MICA	22914	100507436	Gene	Gene	Down-regulation|nmod|START_ENTITY ligand|nsubj|Down-regulation ligand|dobj|END_ENTITY	Down-regulation of the NKG2D ligand MICA by the human_cytomegalovirus glycoprotein UL142 .
17570210	0	NKG2D	4,9	MICA	91,95	NKG2D	MICA	22914	100507436	Gene	Gene	+|compound|START_ENTITY T|nsubj|+ T|ccomp|mediate mediate|nmod|interactions interactions|compound|END_ENTITY	CD4 + NKG2D + T cells in Crohn 's _ disease mediate inflammatory and cytotoxic responses through MICA interactions .
18981088	0	NKG2D	89,94	MICA	102,106	NKG2D	MICA	22914	100507436	Gene	Gene	expression|nmod|START_ENTITY cells|nmod|expression monocytes|nmod|cells Interaction|nmod|monocytes ligand|nsubj|Interaction ligand|dobj|END_ENTITY	Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA .
19793804	0	NKG2D	0,5	MICA	13,17	NKG2D	MICA	22914	100507436	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|retained retained|nsubjpass|END_ENTITY	NKG2D ligand MICA is retained in the cis-Golgi apparatus by human_cytomegalovirus protein UL142 .
21928280	0	NKG2D	37,42	MICA	18,22	NKG2D	MICA	22914	100507436	Gene	Gene	ligand|nmod|START_ENTITY Palmitoylation|appos|ligand Palmitoylation|nmod|END_ENTITY	Palmitoylation of MICA , a ligand for NKG2D , mediates its recruitment to membrane microdomains and promotes its shedding .
23686482	0	NKG2D	51,56	MICA	64,68	NKG2D	MICA	22914	100507436	Gene	Gene	Inhibition|nmod|START_ENTITY ligand|nsubj|Inhibition ligand|dobj|expression expression|compound|END_ENTITY	Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple_myeloma cells : role of STAT3 .
23860405	0	NKG2D	55,60	MICA	84,88	NKG2D	MICA	22914	100507436	Gene	Gene	activity|compound|START_ENTITY modulate|dobj|activity modulate|advcl|regulating regulating|dobj|expression expression|compound|END_ENTITY	Endothelial cell activation and proliferation modulate NKG2D activity by regulating MICA expression and shedding .
24846123	0	NKG2D	44,49	MICA	16,20	NKG2D	MICA	22914	100507436	Gene	Gene	ULBP2-induced|dep|START_ENTITY down-modulation|amod|ULBP2-induced not|nmod|down-modulation END_ENTITY|dep|not	c-Cbl regulates MICA - but not ULBP2-induced NKG2D down-modulation in human NK cells .
26909862	0	NKG2D	52,57	MICA	36,40	NKG2D	MICA	22914	100507436	Gene	Gene	immunosurveillance|compound|START_ENTITY immunosurveillance|compound|END_ENTITY	VEGFR2 targeted antibody fused with MICA stimulates NKG2D mediated immunosurveillance and exhibits potent anti-tumor activity against breast_cancer .
18490733	0	NKG2D	109,114	Macrophage_migration_inhibitory_factor	0,38	NKG2D	Macrophage migration inhibitory factor	22914	4282	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor contributes to the immune escape of ovarian_cancer by down-regulating NKG2D .
23804716	0	NKG2D	0,5	Mcl-1	14,19	NKG2D	Mcl-1	22914	4170	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via phosphatidylinositol 3-kinase .
16116168	0	NKG2D	100,105	NKG2D	22,27	NKG2D	NKG2D	27007(Tax:10090)	27007(Tax:10090)	Gene	Gene	costimulation|compound|START_ENTITY similarities|nmod|costimulation Costimulation|dep|similarities Costimulation|nmod|function function|compound|END_ENTITY	Costimulation through NKG2D enhances murine CD8 + CTL function : similarities and differences between NKG2D and CD28 costimulation .
16116168	0	NKG2D	22,27	NKG2D	100,105	NKG2D	NKG2D	27007(Tax:10090)	27007(Tax:10090)	Gene	Gene	function|compound|START_ENTITY Costimulation|nmod|function Costimulation|dep|similarities similarities|nmod|costimulation costimulation|compound|END_ENTITY	Costimulation through NKG2D enhances murine CD8 + CTL function : similarities and differences between NKG2D and CD28 costimulation .
19424970	0	NKG2D	13,18	NKG2D	51,56	NKG2D	NKG2D	22914	22914	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino_acid in the alpha2 domain .
19424970	0	NKG2D	51,56	NKG2D	13,18	NKG2D	NKG2D	22914	22914	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino_acid in the alpha2 domain .
15048723	0	NKG2D	22,27	NKR-P2	15,21	NKG2D	NKR-P2	24934(Tax:10116)	24934(Tax:10116)	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of NKR-P2 / NKG2D in DC-mediated killing of tumor targets : indicative of a common , innate , target-recognition paradigm ?
20150362	0	NKG2D	47,52	TGF-beta	0,8	NKG2D	TGF-beta	22914	7040	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8 + T cells in glioma patients .
15187109	0	NKG2D	52,57	TGF-beta1	9,18	NKG2D	TGF-beta1	22914	7040	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients .
16342232	0	NKG2D	18,23	UL16_binding_protein-1	31,53	NKG2D	UL16 binding protein-1	22914	80329	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression of the NKG2D ligand UL16_binding_protein-1 -LRB- ULBP-1 -RRB- on dendritic cells .
22754777	0	NKG2D	92,97	ULBP2	26,31	NKG2D	ULBP2	22914	80328	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Tumor suppressors control ULBP2 , an innate surface ligand of the lymphocyte immune receptor NKG2D .
24677544	0	NKG2D	30,35	c-Myc	0,5	NKG2D	c-Myc	22914	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis .
18613644	0	NKG2D	83,88	heat_shock_protein_70	40,61	NKG2D	heat shock protein 70	22914	3308	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Activation of NK cells by extracellular heat_shock_protein_70 through induction of NKG2D ligands on dendritic cells .
1680927	0	NKR-P1	22,28	LY-49	54,59	NKR-P1	LY-49	17059(Tax:10090)	17055(Tax:10090)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49 .
8920872	0	NKR-P1A	31,38	CD16	46,50	NKR-P1A	CD16	3820	2214	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Definition of a natural killer NKR-P1A + / CD56 - / CD16 - functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12 .
16365412	0	NKR-P1A	21,28	CD161	14,19	NKR-P1A	CD161	3820	3820	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD161 -LRB- NKR-P1A -RRB- defines subsets of human CD4 and CD8 T cells with different functional activities .
8920872	0	NKR-P1A	31,38	CD56	40,44	NKR-P1A	CD56	3820	4684	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Definition of a natural killer NKR-P1A + / CD56 - / CD16 - functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12 .
15048723	0	NKR-P2	15,21	NKG2D	22,27	NKR-P2	NKG2D	24934(Tax:10116)	24934(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of NKR-P2 / NKG2D in DC-mediated killing of tumor targets : indicative of a common , innate , target-recognition paradigm ?
9232437	0	NKRP1A	0,6	CD4	61,64	NKRP1A	CD4	3820	920	Gene	Gene	molecule|compound|START_ENTITY involved|nsubjpass|molecule involved|nmod|migration migration|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	NKRP1A molecule is involved in transendothelial migration of CD4 + human T lymphocytes .
9341779	0	NKRP1A	43,49	CD4	38,41	NKRP1A	CD4	3820	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Phenotypic and functional analysis of CD4 + NKRP1A + human T lymphocytes .
21677782	0	NKX2-1	22,28	HOXB5	0,5	NKX2-1	HOXB5	7080	3215	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	HOXB5 cooperates with NKX2-1 in the transcription of human RET .
23259454	0	NKX2-1	0,6	SMAD2	21,26	NKX2-1	SMAD2	7080	4087	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell .
21637825	0	NKX2-3	0,6	endothelin-1	37,49	NKX2-3	endothelin-1	159296	1906	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells .
19479054	0	NKX2-5	0,6	beta-catenin	35,47	NKX2-5	beta-catenin	1482	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes .
23368843	0	NKX3-1	57,63	TWIST1	0,6	NKX3-1	TWIST1	4824	7291	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	TWIST1 , A novel androgen-regulated gene , is a target for NKX3-1 in prostate_cancer cells .
18178852	0	NK_cell_receptor_protein-2	77,103	NK_group_2_member_D	104,123	NK cell receptor protein-2	NK group 2 member D	24934(Tax:10116)	24934(Tax:10116)	Gene	Gene	/|amod|START_ENTITY END_ENTITY|amod|/	The ischemia-responsive protein 94 -LRB- Irp94 -RRB- activates dendritic cells through NK_cell_receptor_protein-2 / NK_group_2_member_D -LRB- NKR-P2 / NKG2D -RRB- leading to their maturation .
18178852	0	NK_group_2_member_D	104,123	NK_cell_receptor_protein-2	77,103	NK group 2 member D	NK cell receptor protein-2	24934(Tax:10116)	24934(Tax:10116)	Gene	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	The ischemia-responsive protein 94 -LRB- Irp94 -RRB- activates dendritic cells through NK_cell_receptor_protein-2 / NK_group_2_member_D -LRB- NKR-P2 / NKG2D -RRB- leading to their maturation .
20126612	0	NK_receptor	11,22	HLA-G	38,43	NK receptor	HLA-G	3804	3135	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Inhibitory NK_receptor recognition of HLA-G : regulation by contact residues and by cell specific expression at the fetal-maternal interface .
17303697	0	NKa	31,34	CD4	26,29	NKa	CD4	6863	920	Gene	Gene	+|compound|START_ENTITY CD8|dep|+ END_ENTITY|dep|CD8	Monoclonal TCR-Vbeta13 .1 + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis : evidence for an antigen-driven chronic T-cell stimulation origin .
18768393	0	NKa	49,52	CD4	44,47	NKa	CD4	6863	920	Gene	Gene	+|dep|START_ENTITY +|compound|END_ENTITY	Expanded cells in monoclonal TCR-alphabeta + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis recognize hCMV antigens .
20739776	0	NKa	7,10	CD4	0,3	NKa	CD4	6863	920	Gene	Gene	+|compound|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|dep|+ T-cell_large_granular_lymphocytic_leukemia|nummod|+ +|compound|END_ENTITY	CD4 + / NKa _ + / CD8 -LRB- dim + -RRB- T-cell_large_granular_lymphocytic_leukemia : a rare entity .
17303697	0	NKa	31,34	CD8	36,39	NKa	CD8	6863	925	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Monoclonal TCR-Vbeta13 .1 + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis : evidence for an antigen-driven chronic T-cell stimulation origin .
18768393	0	NKa	49,52	CD8	54,57	NKa	CD8	6863	925	Gene	Gene	START_ENTITY|dep|+ +|dep|END_ENTITY	Expanded cells in monoclonal TCR-alphabeta + / CD4 + / NKa + / CD8 - / + dim T-LGL lymphocytosis recognize hCMV antigens .
20739776	0	NKa	7,10	CD8	14,17	NKa	CD8	6863	925	Gene	Gene	+|compound|START_ENTITY T-cell_large_granular_lymphocytic_leukemia|dep|+ T-cell_large_granular_lymphocytic_leukemia|compound|END_ENTITY	CD4 + / NKa _ + / CD8 -LRB- dim + -RRB- T-cell_large_granular_lymphocytic_leukemia : a rare entity .
19528259	0	NKp30	98,103	B7-H6	21,26	NKp30	B7-H6	259197	374383	Gene	Gene	ligand|nmod|START_ENTITY cell|acl|ligand cell|nsubj|END_ENTITY	The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans .
21422170	0	NKp30	64,69	B7-H6	101,106	NKp30	B7-H6	259197	374383	Gene	Gene	Structure|nmod|START_ENTITY ligand|nsubj|Structure ligand|xcomp|END_ENTITY	Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6 .
21877119	0	NKp30	6,11	B7-H6	0,5	NKp30	B7-H6	259197	374383	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	B7-H6 / NKp30 interaction : a mechanism of alerting NK cells against tumors .
24780758	0	NKp30	113,118	B7-H6	48,53	NKp30	B7-H6	259197	374383	Gene	Gene	cell-activating|dobj|START_ENTITY cell-activating|nsubj|cell cell|acl|shedding shedding|nmod|END_ENTITY	Metalloprotease-mediated tumor cell shedding of B7-H6 , the ligand of the natural killer cell-activating receptor NKp30 .
26057798	0	NKp30	145,150	B7-H6	80,85	NKp30	B7-H6	259197	374383	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|analysis analysis|nmod|complex complex|nmod|END_ENTITY	Expression , crystallization and X-ray diffraction analysis of a complex between B7-H6 , a tumor cell ligand for the natural cytotoxicity receptor NKp30 , and an inhibitory antibody .
22403253	0	NKp30	14,19	CCL3	62,66	NKp30	CCL3	259197	6348	Gene	Gene	Engagement|nmod|START_ENTITY induces|nsubj|Engagement induces|dobj|production production|nmod|END_ENTITY	Engagement of NKp30 on V 1 T cells induces the production of CCL3 , CCL4 , and CCL5 and suppresses HIV-1 replication .
25315772	0	NKp30	64,69	Galectin-3	15,25	NKp30	Galectin-3	259197	3958	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Tumor-released Galectin-3 , a soluble inhibitory ligand of human NKp30 , plays an important role in tumor escape from NK cell attack .
21168454	0	NKp30	23,28	NKp46	29,34	NKp30	NKp46	259197	9437	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Reduced frequencies of NKp30 + NKp46 + , CD161 + , and NKG2D + NK cells in acute HCV_infection may predict viral clearance .
12646700	0	NKp30	57,62	Transforming_growth_factor_beta_1	0,33	NKp30	Transforming growth factor beta 1	259197	7040	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor_beta_1 inhibits expression of NKp30 and NKG2D receptors : consequences for the NK-mediated killing of dendritic cells .
23874793	0	NKp44	144,149	CD56	152,156	NKp44	CD56	9436	4684	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Natural killer cell cytokine response to M. _ bovis BCG Is associated with inhibited proliferation , increased apoptosis and ultimate depletion of NKp44 -LRB- + -RRB- CD56 -LRB- bright -RRB- cells .
20142432	0	NKp44	6,11	IL-22	12,17	NKp44	IL-22	9436	50616	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human NKp44 + IL-22 + cells and LTi-like cells constitute a stable RORC + lineage distinct from conventional natural killer cells .
18097220	0	NKp44L	74,80	CD4	54,57	NKp44L	CD4	55904	920	Gene	Gene	expression|amod|START_ENTITY depletion|appos|expression influences|nsubj|depletion influences|dobj|relationship relationship|nmod|END_ENTITY	CCR5 or CXCR4 use influences the relationship between CD4 cell depletion , NKp44L expression and NK cytotoxicity in SHIV-infected macaques .
19424050	0	NKp44L	58,64	CD4	79,82	NKp44L	CD4	55904	920	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nmod|cells cells|compound|END_ENTITY	HIV escape from natural killer cytotoxicity : nef inhibits NKp44L expression on CD4 + T cells .
24179999	0	NKp44L	0,6	CD4	21,24	NKp44L	CD4	55904	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	NKp44L expression on CD4 + T cells is associated with impaired_immunological_recovery_in_HIV-infected patients under highly active antiretroviral therapy .
19424050	0	NKp44L	58,64	nef	45,48	NKp44L	nef	55904	6285	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	HIV escape from natural killer cytotoxicity : nef inhibits NKp44L expression on CD4 + T cells .
26630176	0	NKp46	0,5	CD8	44,47	NKp46	CD8	9437	925	Gene	Gene	Cell|compound|START_ENTITY Cell|compound|END_ENTITY	NKp46 + Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine .
26232426	0	NKp46	90,95	IFN-y	44,49	NKp46	IFN-y	9437	3458	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Regulatory Dendritic Cells Restrain NK Cell IFN-y Production through Mechanisms Involving NKp46 , IL-10 , and MHC Class I-Specific Inhibitory Receptors .
26232426	0	NKp46	90,95	IFN-y	44,49	NKp46	IFN-y	9437	3458	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Regulatory Dendritic Cells Restrain NK Cell IFN-y Production through Mechanisms Involving NKp46 , IL-10 , and MHC Class I-Specific Inhibitory Receptors .
21168454	0	NKp46	29,34	NKp30	23,28	NKp46	NKp30	9437	259197	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Reduced frequencies of NKp30 + NKp46 + , CD161 + , and NKG2D + NK cells in acute HCV_infection may predict viral clearance .
16750657	0	NLCAM	73,78	neurolin-like_cell_adhesion_molecule	35,71	NLCAM	neurolin-like cell adhesion molecule	323919(Tax:7955)	323919(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Comparison of neurolin -LRB- ALCAM -RRB- and neurolin-like_cell_adhesion_molecule -LRB- NLCAM -RRB- expression in zebrafish .
21551456	0	NLGN2	91,96	neuroligin-2	72,84	NLGN2	neuroligin-2	57555	57555	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and functional characterization of rare mutations of the neuroligin-2 gene -LRB- NLGN2 -RRB- associated with schizophrenia .
25833695	0	NLK	77,80	MiR-197	0,7	NLK	MiR-197	51701	406974	Gene	Gene	regulating|dobj|START_ENTITY induces|advcl|regulating induces|nsubj|END_ENTITY	MiR-197 induces Taxol resistance in human ovarian_cancer cells by regulating NLK .
20116374	0	NLK	18,21	Nemo-like_kinase	0,16	NLK	Nemo-like kinase	18099(Tax:10090)	18099(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Nemo-like_kinase -LRB- NLK -RRB- expression in osteoblastic cells and suppression of osteoblastic differentiation .
23325309	0	NLK	32,35	Nemo-like_kinase	14,30	NLK	Nemo-like kinase	497961(Tax:10116)	497961(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Nemo-like_kinase -LRB- NLK -RRB- in the brain in a rat experimental subarachnoid_hemorrhage model .
26588989	0	NLK	0,3	Raptor	19,25	NLK	Raptor	51701	57521	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition .
24972723	0	NLK	0,3	miR-199a-3p	23,34	NLK	miR-199a-3p	51701	406977	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	NLK , a novel target of miR-199a-3p , functions as a tumor suppressor in colorectal_cancer .
12039044	0	NLK	31,34	nemo-like_kinase	36,52	NLK	nemo-like kinase	51701	51701	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Genomic structure of the human NLK -LRB- nemo-like_kinase -RRB- gene and analysis of its promoter region .
23857283	0	NLK	45,48	nemo-like_kinase	27,43	NLK	nemo-like kinase	51701	51701	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of nemo-like_kinase -LRB- NLK -RRB- expression in patients with gallbladder_cancer .
20434986	0	NLRC5	0,5	NF-kappaB	31,40	NLRC5	NF-kappaB	84166	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways .
26086088	0	NLRP1	34,39	ATF4	21,25	NLRP1	ATF4	22861	468	Gene	Gene	Expression|compound|START_ENTITY Induces|dobj|Expression Induces|nsubj|END_ENTITY	Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress .
25744023	0	NLRP1	9,14	Caspase-1	42,51	NLRP1	Caspase-1	22861	834	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal_degeneration-associated Caspase-6 activation .
18056399	0	NLRP2	0,5	NF-kappaB	27,36	NLRP2	NF-kappaB	55655	4790	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|pathway pathway|amod|END_ENTITY	NLRP2 , an inhibitor of the NF-kappaB pathway , is transcriptionally activated by NF-kappaB and exhibits a nonfunctional allelic variant .
18056399	0	NLRP2	0,5	NF-kappaB	80,89	NLRP2	NF-kappaB	55655	4790	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	NLRP2 , an inhibitor of the NF-kappaB pathway , is transcriptionally activated by NF-kappaB and exhibits a nonfunctional allelic variant .
25552542	0	NLRP3	121,126	Caspase-1	93,102	NLRP3	Caspase-1	114548	834	Gene	Gene	Absence|nmod|START_ENTITY END_ENTITY|nmod|Absence	Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling .
26989816	0	NLRP3	75,80	Caspase-1	14,23	NLRP3	Caspase-1	216799(Tax:10090)	12362(Tax:10090)	Gene	Gene	Independently|nmod|START_ENTITY END_ENTITY|dobj|Independently	TNF-a Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells .
26100631	0	NLRP3	42,47	Caspase-8	0,9	NLRP3	Caspase-8	216799(Tax:10090)	12370(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling .
25607115	0	NLRP3	20,25	EIF2AK2	50,57	NLRP3	EIF2AK2	114548	5610	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory_bowel_disease .
25917098	0	NLRP3	26,31	EP4	64,67	NLRP3	EP4	114548	5734	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|Receptor Receptor|compound|END_ENTITY	Prostaglandin_E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic_AMP in Human Macrophages .
25447538	0	NLRP3	51,56	GFI1	25,29	NLRP3	GFI1	114548	2672	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	The transcription factor GFI1 negatively regulates NLRP3 inflammasome activation in macrophages .
25271165	0	NLRP3	70,75	G_Protein_Signaling_Modulator-3	0,31	NLRP3	G Protein Signaling Modulator-3	216799(Tax:10090)	106512(Tax:10090)	Gene	Gene	Activity|nmod|START_ENTITY Inhibits|dobj|Activity Inhibits|nsubj|END_ENTITY	G_Protein_Signaling_Modulator-3 Inhibits the Inflammasome Activity of NLRP3 .
26471297	0	NLRP3	43,48	Histone_deacetylase_6	0,21	NLRP3	Histone deacetylase 6	114548	10013	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Histone_deacetylase_6 negatively regulates NLRP3 inflammasome activation .
26412089	0	NLRP3	100,105	IL-10	71,76	NLRP3	IL-10	114548	3586	Gene	Gene	Expression|compound|START_ENTITY Regulation|nmod|Expression Regulation|compound|END_ENTITY	Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation .
20835230	0	NLRP3	18,23	IL-1b	100,105	NLRP3	IL-1b	114548	3553	Gene	Gene	inflammasome|compound|START_ENTITY Activation|nmod|inflammasome provides|nsubj|Activation provides|dobj|mechanism mechanism|nmod|END_ENTITY	Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes .
21239716	0	NLRP3	88,93	IL-1b	60,65	NLRP3	IL-1b	114548	3553	Gene	Gene	inflammasome|compound|START_ENTITY induce|nmod|inflammasome induce|dobj|secretion secretion|compound|END_ENTITY	Basic calcium_phosphate crystals induce monocyte/macrophage IL-1b secretion through the NLRP3 inflammasome in vitro .
21278344	0	NLRP3	106,111	IL-1b	72,77	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasome|compound|START_ENTITY activating|dobj|inflammasome trigger|advcl|activating trigger|dobj|secretion secretion|compound|END_ENTITY	Cutting edge : cyclic polypeptide and aminoglycoside antibiotics trigger IL-1b secretion by activating the NLRP3 inflammasome .
22488359	0	NLRP3	67,72	IL-1b	56,61	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasome|compound|START_ENTITY piece|dep|inflammasome piece|nmod|puzzle puzzle|nmod|END_ENTITY	An additional piece in the puzzle of neutrophil-derived IL-1b : the NLRP3 inflammasome .
22711073	0	NLRP3	8,13	IL-1b	59,64	NLRP3	IL-1b	114548	3553	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of NLRP3 and CARD8 in the regulation of TNF-a induced IL-1b release in vascular smooth muscle cells .
22926439	0	NLRP3	0,5	IL-1b	97,102	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasome|nsubj|START_ENTITY inflammasome|nmod|fibrils fibrils|nmod|source source|nmod|END_ENTITY	NLRP3 inflammasome activation in macrophage cell lines by prion_protein fibrils as the source of IL-1b and neuronal_toxicity .
23209696	0	NLRP3	141,146	IL-1b	68,73	NLRP3	IL-1b	114548	3553	Gene	Gene	inflammasome|compound|START_ENTITY activation|nmod|inflammasome required|dobj|activation required|nsubj|enterohemolysin enterohemolysin|acl|induced induced|xcomp|END_ENTITY	Enterohemorrhagic Escherichia_coli specific enterohemolysin induced IL-1b in human macrophages and EHEC-induced IL-1b required activation of NLRP3 inflammasome .
23315075	0	NLRP3	89,94	IL-1b	37,42	NLRP3	IL-1b	114548	3553	Gene	Gene	inflammasome|compound|START_ENTITY activating|dobj|inflammasome induces|advcl|activating induces|dobj|production production|compound|END_ENTITY	Self double-stranded -LRB- ds -RRB- DNA induces IL-1b production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies .
23633957	0	NLRP3	29,34	IL-1b	0,5	NLRP3	IL-1b	114548	3553	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	IL-1b production through the NLRP3 inflammasome by hepatic macrophages_links_hepatitis_C_virus_infection_with_liver_inflammation and disease .
23884315	0	NLRP3	56,61	IL-1b	32,37	NLRP3	IL-1b	114548	3553	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Propionibacterium_acnes Induces IL-1b secretion via the NLRP3 inflammasome in human monocytes .
24464629	0	NLRP3	48,53	IL-1b	13,18	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY induces|advcl|activating induces|dobj|secretion secretion|compound|END_ENTITY	Heme induces IL-1b secretion through activating NLRP3 in kidney_inflammation .
24470197	0	NLRP3	36,41	IL-1b	64,69	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	secretion|nummod|START_ENTITY secretion|compound|END_ENTITY	Follistatin-like_protein_1 enhances NLRP3 inflammasome-mediated IL-1b secretion from monocytes and macrophages .
24692555	0	NLRP3	89,94	IL-1b	68,73	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasomes|nummod|START_ENTITY activating|dobj|inflammasomes END_ENTITY|acl|activating	RNA and b-hemolysin of group B Streptococcus induce interleukin-1b -LRB- IL-1b -RRB- by activating NLRP3 inflammasomes in mouse macrophages .
24894187	0	NLRP3	30,35	IL-1b	64,69	NLRP3	IL-1b	114548	3553	Gene	Gene	Activation|nmod|START_ENTITY inflammasome|nsubj|Activation inflammasome|dobj|activity activity|acl|using using|dobj|END_ENTITY	Activation and measurement of NLRP3 inflammasome activity using IL-1b in human monocyte-derived dendritic cells .
25231464	0	NLRP3	67,72	IL-1b	24,29	NLRP3	IL-1b	114548	3553	Gene	Gene	Inflammasome|compound|START_ENTITY keratinocytes|nmod|Inflammasome secretion|nmod|keratinocytes secretion|nsubj|END_ENTITY	Serum_amyloid_A Induces IL-1b secretion from keratinocytes via the NLRP3 Inflammasome .
25294243	0	NLRP3	27,32	IL-1b	54,59	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	START_ENTITY|dep|Production Production|compound|END_ENTITY	Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1b Production .
25311115	0	NLRP3	9,14	IL-1b	72,77	NLRP3	IL-1b	114548	3553	Gene	Gene	activity|compound|START_ENTITY regulates|nsubj|activity regulates|dobj|production production|compound|END_ENTITY	Impaired NLRP3 inflammasome activity during fetal development regulates IL-1b production in human monocytes .
25386048	0	NLRP3	87,92	IL-1b	25,30	NLRP3	IL-1b	114548	3553	Gene	Gene	pathways|compound|START_ENTITY inhibits|nmod|pathways inhibits|dobj|expression expression|amod|END_ENTITY	Scropolioside B inhibits IL-1b and cytokines expression through NF-kB and inflammasome NLRP3 pathways .
25626736	0	NLRP3	66,71	IL-1b	94,99	NLRP3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Monounsaturated_Fatty_Acid-Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome-Mediated IL-1b Secretion and Insulin Resistance Despite Obesity .
25834143	0	NLRP3	106,111	IL-1b	28,33	NLRP3	IL-1b	114548	3553	Gene	Gene	inflammasome|nummod|START_ENTITY activation|nmod|inflammasome induces|nmod|activation induces|dobj|production production|amod|END_ENTITY	Helicobacter_pylori induces IL-1b and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway .
25897296	0	NLRP3	12,17	IL-1b	59,64	NLRP3	IL-1b	114548	3553	Gene	Gene	Role|nmod|START_ENTITY inflammasome|nsubj|Role inflammasome|nmod|release release|nmod|END_ENTITY	Role of the NLRP3 inflammasome in the transient release of IL-1b induced by monosodium_urate crystals in human fibroblast-like synoviocytes .
26027935	0	NLRP3	26,31	IL-1b	53,58	NLRP3	IL-1b	114548	3553	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Diverse Activators of the NLRP3 Inflammasome Promote IL-1b Secretion by Triggering Necrosis .
26102024	0	NLRP3	82,87	IL-1b	32,37	NLRP3	IL-1b	114548	3553	Gene	Gene	activation|compound|START_ENTITY cells|nmod|activation induces|nmod|cells induces|dobj|release release|compound|END_ENTITY	Inhibition of autophagy induces IL-1b release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress .
26398903	0	NLRP3	139,144	IL-1b	167,172	NLRP3	IL-1b	114548	3553	Gene	Gene	Induction|compound|START_ENTITY Induction|compound|END_ENTITY	The Endoribonuclease Activity Essential for the Nonstructural Protein 11 of Porcine_Reproductive_and_Respiratory_Syndrome_Virus to Inhibit NLRP3 Inflammasome-Mediated IL-1b Induction .
26435646	0	NLRP3	22,27	IL-1b	51,56	NLRP3	IL-1b	114548	3553	Gene	Gene	secretion|nummod|START_ENTITY secretion|compound|END_ENTITY	Urate crystals induce NLRP3 inflammasome-dependent IL-1b secretion and proliferation in isolated primary human T-cells .
26616294	0	NLRP3	94,99	IL-1b	59,64	NLRP3	IL-1b	114548	3553	Gene	Gene	activation|dep|START_ENTITY inhibiting|dobj|activation down-regulates|advcl|inhibiting down-regulates|dobj|release release|compound|END_ENTITY	Atrial natriuretic peptide down-regulates LPS/ATP-mediated IL-1b release by inhibiting NF-kB , NLRP3 inflammasome and caspase-1 activation in THP-1 cells .
26830368	0	NLRP3	63,68	IL-1b	24,29	NLRP3	IL-1b	114548	3553	Gene	Gene	Inflammasome|compound|START_ENTITY Via|dobj|Inflammasome Via|nsubj|Secretion Secretion|compound|END_ENTITY	Interleukin-17A Induces IL-1b Secretion From RPE Cells Via the NLRP3 Inflammasome .
26877061	0	NLRP3	34,39	IL-1b	63,68	NLRP3	IL-1b	114548	3553	Gene	Gene	secretion|nummod|START_ENTITY secretion|compound|END_ENTITY	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1b secretion in response to ATP .
26901245	0	NLRP3	35,40	IL-1b	110,115	NLRP3	IL-1b	114548	3553	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1b in the HUVEC Endothelial Cell Line .
26959386	0	NLRP3	106,111	IL-1b	30,35	NLRP3	IL-1b	114548	3553	Gene	Gene	inflammasome|compound|START_ENTITY activating|dobj|inflammasome induces|advcl|activating induces|dobj|production production|compound|END_ENTITY	Trichomonas_vaginalis induces IL-1b production in a human prostate epithelial cell line by activating the NLRP3 inflammasome via reactive oxygen species and potassium ion efflux .
20561679	0	NLRP3	68,73	IL-1beta	96,104	NLRP3	IL-1beta	114548	3553	Gene	Gene	production|nummod|START_ENTITY production|compound|END_ENTITY	The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production , ROS production and endosomal rupture .
26830368	0	NLRP3	63,68	Interleukin-17A	0,15	NLRP3	Interleukin-17A	114548	3605	Gene	Gene	Inflammasome|compound|START_ENTITY Via|dobj|Inflammasome Via|nsubj|Secretion Secretion|compound|END_ENTITY	Interleukin-17A Induces IL-1b Secretion From RPE Cells Via the NLRP3 Inflammasome .
21183380	0	NLRP3	82,87	Interleukin-1b	0,14	NLRP3	Interleukin-1b	114548	3553	Gene	Gene	inflammasome|compound|START_ENTITY role|nmod|inflammasome activation|dep|role activation|amod|END_ENTITY	Interleukin-1b activation during acute_joint_inflammation : a limited role for the NLRP3 inflammasome in vivo .
25548278	0	NLRP3	0,5	Interleukin-1b	112,126	NLRP3	Interleukin-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	Protein_Deficiency|compound|START_ENTITY Exacerbates|nsubj|Protein_Deficiency Exacerbates|nmod|Independent Independent|nmod|END_ENTITY	NLRP3 Protein_Deficiency Exacerbates Hyperoxia-induced Lethality through Stat3 Protein Signaling Independent of Interleukin-1b .
26502906	0	NLRP3	26,31	Interleukin-1b	108,122	NLRP3	Interleukin-1b	114548	3553	Gene	Gene	Pathway|compound|START_ENTITY Activate|dobj|Pathway Activate|xcomp|Promote Promote|dobj|Production Production|nmod|END_ENTITY	Shiga Toxins Activate the NLRP3 Inflammasome Pathway to Promote both Production of Proinflammatory Cytokine Interleukin-1b and Apoptotic Cell Death .
23942110	0	NLRP3	29,34	LRRFIP2	0,7	NLRP3	LRRFIP2	114548	9209	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition .
25041941	0	NLRP3	63,68	NF-kB	56,61	NLRP3	NF-kB	114548	81736(Tax:10116)	Gene	Gene	production|dep|START_ENTITY production|amod|END_ENTITY	Vinpocetine inhibits amyloid-beta induced activation of NF-kB , NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells .
27061450	0	NLRP3	74,79	Nod-like_Receptor_Protein_3	45,72	NLRP3	Nod-like Receptor Protein 3	287362(Tax:10116)	287362(Tax:10116)	Gene	Gene	Activation|appos|START_ENTITY Activation|compound|END_ENTITY	Agmatine Reverses Sub-Chronic Stress-induced Nod-like_Receptor_Protein_3 -LRB- NLRP3 -RRB- Activation and Cytokine Response in Rats .
26928328	0	NLRP3	57,62	TLR8	70,74	NLRP3	TLR8	114548	51311	Gene	Gene	START_ENTITY|nmod|Activity Activity|compound|END_ENTITY	Coordinated Activation of Toll-Like_Receptor8 -LRB- TLR8 -RRB- and NLRP3 by the TLR8 Agonist , VTX-2337 , Ignites Tumoricidal Natural Killer Cell Activity .
25015733	0	NLRP3	15,20	TXNIP	0,5	NLRP3	TXNIP	216799(Tax:10090)	56338(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial_ischemia / reperfusion injury .
25138219	0	NLRP3	29,34	Thioredoxin-Interacting_Protein	84,115	NLRP3	Thioredoxin-Interacting Protein	216799(Tax:10090)	56338(Tax:10090)	Gene	Gene	Nod-like_Receptor_Protein_3|appos|START_ENTITY Inflammasome|nsubj|Nod-like_Receptor_Protein_3 Inflammasome|dobj|Injury Injury|nmod|END_ENTITY	Nod-like_Receptor_Protein_3 -LRB- NLRP3 -RRB- Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting_Protein -LRB- TXNIP -RRB- during Hyperhomocysteinemia .
24201577	0	NLRP3	60,65	Thioredoxin-interacting_protein	0,31	NLRP3	Thioredoxin-interacting protein	287362(Tax:10116)	117514(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Thioredoxin-interacting_protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet .
21048113	0	NLRP3	49,54	Tripartite-motif_protein_30	0,27	NLRP3	Tripartite-motif protein 30	216799(Tax:10090)	20128(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Tripartite-motif_protein_30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production .
25800347	0	NLRP3	65,70	Xanthine_oxidoreductase	0,23	NLRP3	Xanthine oxidoreductase	114548	7498	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Xanthine_oxidoreductase regulates macrophage IL1b secretion upon NLRP3 inflammasome activation .
25605870	0	NLRP3	19,24	caspase-1	47,56	NLRP3	caspase-1	114548	834	Gene	Gene	activation|nummod|START_ENTITY activation|amod|END_ENTITY	Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization .
21464611	0	NLRP3	103,108	interleukin-1b	62,76	NLRP3	interleukin-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasome|compound|START_ENTITY activation|nmod|inflammasome induce|nmod|activation induce|dobj|processing processing|nmod|END_ENTITY	Doxorubicin and daunorubicin induce processing and release of interleukin-1b through activation of the NLRP3 inflammasome .
21600797	0	NLRP3	40,45	interleukin-1b	66,80	NLRP3	interleukin-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|amod|END_ENTITY	Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1b activation and severe autoinflammation in mice .
21625424	0	NLRP3	86,91	interleukin-1b	43,57	NLRP3	interleukin-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasome|compound|START_ENTITY activating|dobj|inflammasome trigger|advcl|activating trigger|dobj|secretion secretion|amod|END_ENTITY	Polyene_macrolide antifungal drugs trigger interleukin-1b secretion by activating the NLRP3 inflammasome .
21994456	0	NLRP3	33,38	interleukin-1b	61,75	NLRP3	interleukin-1b	114548	3553	Gene	Gene	secretion|nummod|START_ENTITY secretion|amod|END_ENTITY	Measles_virus V protein inhibits NLRP3 inflammasome-mediated interleukin-1b secretion .
22529966	0	NLRP3	26,31	interleukin-1b	86,100	NLRP3	interleukin-1b	114548	3553	Gene	Gene	polymorphism|nmod|START_ENTITY alteration|nsubj|polymorphism alteration|acl|leading leading|nmod|production production|amod|END_ENTITY	The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1b and IL-18 production .
22796220	0	NLRP3	122,127	interleukin-1b	54,68	NLRP3	interleukin-1b	114548	3553	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Oxidized low-density lipoprotein induces secretion of interleukin-1b by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation .
24692555	0	NLRP3	89,94	interleukin-1b	52,66	NLRP3	interleukin-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasomes|nummod|START_ENTITY activating|dobj|inflammasomes IL-1b|acl|activating IL-1b|amod|END_ENTITY	RNA and b-hemolysin of group B Streptococcus induce interleukin-1b -LRB- IL-1b -RRB- by activating NLRP3 inflammasomes in mouse macrophages .
25847326	0	NLRP3	0,5	interleukin-1b	58,72	NLRP3	interleukin-1b	114548	3553	Gene	Gene	inflammasome|compound|START_ENTITY responsible|nsubj|inflammasome responsible|xcomp|inducing inducing|xcomp|END_ENTITY	NLRP3 inflammasome is responsible for Hantavirus inducing interleukin-1b in THP-1 cells .
26074413	0	NLRP3	65,70	interleukin-1b	27,41	NLRP3	interleukin-1b	114548	3553	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Dysregulated production of interleukin-1b upon activation of the NLRP3 inflammasome in patients with familial_Mediterranean_fever .
24127597	0	NLRP3	50,55	mitofusin_2	22,33	NLRP3	mitofusin 2	114548	9927	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Mitochondrial protein mitofusin_2 is required for NLRP3 inflammasome activation after RNA virus infection .
22883233	0	NLRP3	62,67	thioredoxin-interacting_protein	14,45	NLRP3	thioredoxin-interacting protein	216799(Tax:10090)	56338(Tax:10090)	Gene	Gene	inflammasome|compound|START_ENTITY activate|dobj|inflammasome END_ENTITY|xcomp|activate	IRE1a induces thioredoxin-interacting_protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress .
25499441	0	NLRP3	92,97	thioredoxin-interacting_protein	60,91	NLRP3	thioredoxin-interacting protein	114548	10628	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting_protein / NLRP3 inflammasome activation with regulation of AMPK in endothelial cells .
18751440	0	NLRP7	14,19	PYPAF3	21,27	NLRP7	PYPAF3	199713	199713	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Expression of NLRP7 -LRB- PYPAF3 , NALP7 -RRB- protein in endometrial_cancer tissues .
26121690	0	NLRP7	0,5	ZBTB16	102,108	NLRP7	ZBTB16	199713	7704	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	NLRP7 , Involved in Hydatidiform Molar Pregnancy -LRB- HYDM1 -RRB- , Interacts with the Transcriptional Repressor ZBTB16 .
18591937	0	NLRR1	110,115	neuronal_leucine-rich_repeat_protein-1	70,108	NLRR1	neuronal leucine-rich repeat protein-1	57633	57633	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	N-MYC promotes cell proliferation through a direct transactivation of neuronal_leucine-rich_repeat_protein-1 -LRB- NLRR1 -RRB- gene in neuroblastoma .
23771350	0	NLS1	62,66	aristaless-related_homeobox	18,45	NLS1	aristaless-related homeobox	84879	170302	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Nuclear import of aristaless-related_homeobox protein via its NLS1 regulates its transcriptional function .
9066685	0	NM23	10,14	MTS1	16,20	NM23	MTS1	4830	6298	Gene	Gene	START_ENTITY|dep|ratio ratio|nummod|END_ENTITY	Increased NM23 : MTS1 ratio inversely correlated with metastasis behaviour in human lung_squamous_cell_carcinoma .
8406509	0	NM23	25,29	NME2	36,40	NM23	NME2	4830	4831	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of a second NM23 gene , NME2 , to chromosome 17q21-q22 .
18983998	0	NM23	55,59	YNK1	0,4	NM23	YNK1	4830	853798(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	YNK1 , the yeast homolog of human metastasis suppressor NM23 , is required for repair of UV radiation - and etoposide-induced DNA damage .
23505541	0	NM23-H1	14,21	MUC1	0,4	NM23-H1	MUC1	4830	4582	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	MUC1 * ligand , NM23-H1 , is a novel growth factor that maintains human stem cells in a more na ve state .
8297127	0	NM23-H1	55,62	NME1	64,68	NM23-H1	NME1	4830	4830	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic PCR-SSCP analysis of the metastasis associated NM23-H1 -LRB- NME1 -RRB- gene : a study on colorectal_cancer .
17916563	0	NM23-H1	0,7	p53	68,71	NM23-H1	p53	4830	7157	Gene	Gene	suppressor|compound|START_ENTITY STRAP|nsubj|suppressor STRAP|dobj|function function|compound|END_ENTITY	NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function .
8163469	0	NMB-R	43,48	neuromedin_B	19,31	NMB-R	neuromedin B	25264(Tax:10116)	25264(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Desensitization of neuromedin_B receptors -LRB- NMB-R -RRB- on native and NMB-R-transfected cells involves down-regulation and internalization .
12231437	0	NMB-R	94,99	neuromedin_B_receptor	71,92	NMB-R	neuromedin B receptor	18101(Tax:10090)	18101(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Restraint stress impaired maternal behavior in female mice lacking the neuromedin_B_receptor -LRB- NMB-R -RRB- gene .
22536327	0	NMDAR	115,120	N-methyl-D-aspartate_receptor	84,113	NMDAR	N-methyl-D-aspartate receptor	14810(Tax:10090)	14810(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Prion_protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate_receptor -LRB- NMDAR -RRB- activity .
17292799	0	NMDAR1	109,115	CA1	96,99	NMDAR1	CA1	14810(Tax:10090)	12346(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Effects of enriched environment on gene expression and signal pathways in cortex of hippocampal CA1 specific NMDAR1 knockout mice .
10762705	0	NMDAR1	57,63	N-methyl-D-aspartate_receptor	26,55	NMDAR1	N-methyl-D-aspartate receptor	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Hippocampal expression of N-methyl-D-aspartate_receptor -LRB- NMDAR1 -RRB- subunit splice variant mRNA is altered by developmental exposure to Pb -LRB- 2 + -RRB- .
8399301	0	NMDAR1	93,99	N-methyl-D-aspartate_receptor_1	60,91	NMDAR1	N-methyl-D-aspartate receptor 1	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and analysis of the 5 ' flanking sequence of the rat N-methyl-D-aspartate_receptor_1 -LRB- NMDAR1 -RRB- gene .
15338240	0	NMDAR1	56,62	N-methyl-D-aspartate_receptors	24,54	NMDAR1	N-methyl-D-aspartate receptors	2902	2902	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal N-methyl-D-aspartate_receptors -LRB- NMDAR1 -RRB- depends on formation of the granular layer -- analysis in diseases with parakeratotic cornification .
1436707	0	NMDAR1	50,56	NMDA_receptor	35,48	NMDAR1	NMDA receptor	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|mRNA mRNA|nmod|END_ENTITY	Expression of the mRNA for the rat NMDA_receptor -LRB- NMDAR1 -RRB- in the sensory and autonomic ganglion neurons .
8041510	0	NMDAR1	15,21	NMDA_receptor	0,13	NMDAR1	NMDA receptor	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	NMDA_receptor -LRB- NMDAR1 -RRB- expression in the rat hippocampus after forebrain_ischemia .
8883956	0	NMDAR1	54,60	NMDA_receptor_subunit	31,52	NMDAR1	NMDA receptor subunit	397953(Tax:8355)	397953(Tax:8355)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of a functional NMDA_receptor_subunit -LRB- NMDAR1 -RRB- in baculovirus-infected Trichoplusia ni insect cells .
11317224	0	NMDAR2B	25,32	GRIN2B	34,40	NMDAR2B	GRIN2B	2904	2904	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the NMDAR2B -LRB- GRIN2B -RRB- gene in schizophrenia .
1436707	0	NMDA_receptor	35,48	NMDAR1	50,56	NMDA receptor	NMDAR1	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	mRNA|nmod|START_ENTITY Expression|nmod|mRNA Expression|appos|END_ENTITY	Expression of the mRNA for the rat NMDA_receptor -LRB- NMDAR1 -RRB- in the sensory and autonomic ganglion neurons .
8041510	0	NMDA_receptor	0,13	NMDAR1	15,21	NMDA receptor	NMDAR1	24408(Tax:10116)	24408(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	NMDA_receptor -LRB- NMDAR1 -RRB- expression in the rat hippocampus after forebrain_ischemia .
8883956	0	NMDA_receptor_subunit	31,52	NMDAR1	54,60	NMDA receptor subunit	NMDAR1	397953(Tax:8355)	397953(Tax:8355)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of a functional NMDA_receptor_subunit -LRB- NMDAR1 -RRB- in baculovirus-infected Trichoplusia ni insect cells .
25652449	0	NMDA_receptor_subunit_GluN3A	30,58	NR3A	60,64	NMDA receptor subunit GluN3A	NR3A	242443(Tax:10090)	242443(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A neuroprotective role of the NMDA_receptor_subunit_GluN3A -LRB- NR3A -RRB- in ischemic_stroke of the adult mouse .
20671611	0	NME1	54,58	CSNK1A1	26,33	NME1	CSNK1A1	4830	1452	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|END_ENTITY	Gene expression levels of CSNK1A1 and AAC-11 , but not NME1 , in tumor tissues as prognostic factors in NSCLC patients .
8297127	0	NME1	64,68	NM23-H1	55,62	NME1	NM23-H1	4830	4830	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic PCR-SSCP analysis of the metastasis associated NM23-H1 -LRB- NME1 -RRB- gene : a study on colorectal_cancer .
21504894	0	NME2	20,24	MDM2	0,4	NME2	MDM2	4831	4193	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MDM2 interacts with NME2 -LRB- non-metastatic_cells_2 , protein -RRB- and suppresses the ability of NME2 to negatively regulate cell motility .
8406509	0	NME2	36,40	NM23	25,29	NME2	NM23	4831	4830	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization of a second NM23 gene , NME2 , to chromosome 17q21-q22 .
26896769	0	NME2	0,4	PTP	21,24	NME2	PTP	4831	10076	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	NME2 associates with PTP to transduce signals from chondroitin sulfate proteoglycans .
23068101	0	NMHC_IIA	59,67	MYBPH	0,5	NMHC IIA	MYBPH	4627	4608	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MYBPH inhibits NM_IIA_assembly via direct interaction with NMHC_IIA and reduces cell motility .
9170521	0	NMP22	103,108	NMP22	23,28	NMP22	NMP22	4926	4926	Gene	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|END_ENTITY	-LSB- Evaluation of urinary NMP22 -LRB- nuclear_matrix_protein_22 -RRB- as a diagnostic marker for urothelial cancer -- NMP22 as a urinary marker for surveillance of bladder_cancer .
9170521	0	NMP22	23,28	NMP22	103,108	NMP22	NMP22	4926	4926	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|END_ENTITY	-LSB- Evaluation of urinary NMP22 -LRB- nuclear_matrix_protein_22 -RRB- as a diagnostic marker for urothelial cancer -- NMP22 as a urinary marker for surveillance of bladder_cancer .
11583354	0	NMP22	41,46	nuclear_matrix_protein_22	14,39	NMP22	nuclear matrix protein 22	4926	4926	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of nuclear_matrix_protein_22 -LRB- NMP22 -RRB- as a tumor marker in the detection of bladder_cancer .
9076459	0	NMP22	50,55	nuclear_matrix_protein_22	23,48	NMP22	nuclear matrix protein 22	4926	4926	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Clinical evaluation of nuclear_matrix_protein_22 -LRB- NMP22 -RRB- in urine as a novel marker for urothelial_cancer .
14566681	0	NMP_22	24,30	nuclear_matrix_protein_22	32,57	NMP 22	nuclear matrix protein 22	4926	4926	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Clinical study of urine NMP_22 -LRB- nuclear_matrix_protein_22 -RRB- as a tumor marker in urinary_epithelial_cancer .
15644961	0	NMT	71,74	N-myristoyl_transferase	46,69	NMT	N-myristoyl transferase	543128(Tax:4565)	543128(Tax:4565)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of a gene encoding N-myristoyl_transferase -LRB- NMT -RRB- from Triticum_aestivum -LRB- bread_wheat -RRB- .
18190904	0	NMY-2	23,28	UNC-45	0,6	NMY-2	UNC-45	172562(Tax:6239)	175206(Tax:6239)	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|END_ENTITY	UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. _ elegans .
9192856	0	NNP-1	4,9	D21S2056E	16,25	NNP-1	D21S2056E	8568	8568	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The NNP-1 gene -LRB- D21S2056E -RRB- , which encodes a novel nuclear protein , maps in close proximity to the cystatin_B gene within the EPM1 and APECED critical region on 21q22 .3 .
15606508	0	NNP-1	20,25	novel_nuclear_protein-1	27,50	NNP-1	novel nuclear protein-1	8568	8568	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Upregulation of the NNP-1 -LRB- novel_nuclear_protein-1 , D21S2056E -RRB- gene in keloid tissue determined by cDNA microarray and in situ hybridization .
26327385	0	NO66	48,52	Rpl8	86,90	NO66	Rpl8	79697	6132	Gene	Gene	Structure|nmod|START_ENTITY complexed|nsubj|Structure complexed|nmod|END_ENTITY	Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8 .
23839082	0	NOD1	30,34	PSMA7	0,5	NOD1	PSMA7	10392	5688	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PSMA7 directly interacts with NOD1 and regulates its function .
22848741	0	NOD1	0,4	TLR2	21,25	NOD1	TLR2	10392	7097	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells .
16757890	0	NOD1	17,21	TLR4	39,43	NOD1	TLR4	107607(Tax:10090)	21898(Tax:10090)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages .
24806487	0	NOD1	106,110	nucleotide-binding_oligomerization_domain_1	61,104	NOD1	nucleotide-binding oligomerization domain 1	10392	10392	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Identification of selective small molecule inhibitors of the nucleotide-binding_oligomerization_domain_1 -LRB- NOD1 -RRB- signaling pathway .
26915562	0	NOD1	53,57	nucleotide-binding_oligomerization_domain_1	8,51	NOD1	nucleotide-binding oligomerization domain 1	10392	10392	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of nucleotide-binding_oligomerization_domain_1 -LRB- NOD1 -RRB- in pericyte-mediated vascular_inflammation .
17907287	0	NOD1	52,56	nucleotide_oligomerization_domain_1	15,50	NOD1	nucleotide oligomerization domain 1	10392	10392	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Influence of a nucleotide_oligomerization_domain_1 -LRB- NOD1 -RRB- polymorphism and NOD2 mutant alleles on Crohn 's _ disease phenotype .
12360101	0	NOD2	100,104	CARD15	92,98	NOD2	CARD15	64127	64127	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Response to infliximab treatment in Crohn 's _ disease is not associated with mutations in the CARD15 -LRB- NOD2 -RRB- gene : an analysis in 534 patients from two multicenter , prospective GCP-level trials .
12671897	0	NOD2	55,59	CARD15	61,67	NOD2	CARD15	64127	64127	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	TNF-alpha and IFN-gamma regulate the expression of the NOD2 -LRB- CARD15 -RRB- gene in human intestinal epithelial cells .
12923865	0	NOD2	45,49	CARD15	37,43	NOD2	CARD15	64127	64127	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between mutations in the CARD15 -LRB- NOD2 -RRB- gene and Crohn 's _ disease in Israeli Jewish patients .
15479689	0	NOD2	0,4	CARD15	6,12	NOD2	CARD15	64127	64127	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	NOD2 -LRB- CARD15 -RRB- mutations in Crohn 's _ disease are associated with diminished mucosal alpha-defensin expression .
17719742	0	NOD2	97,101	CARD15	103,109	NOD2	CARD15	64127	64127	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification , evolution , and association study of a novel promoter and first exon of the human NOD2 -LRB- CARD15 -RRB- gene .
12020527	0	NOD2	15,19	CARD_15	21,28	NOD2	CARD 15	64127	64127	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of NOD2 -LRB- CARD_15 -RRB- genotype with clinical course of Crohn 's _ disease : a cohort study .
23973922	0	NOD2	87,91	COX2	105,109	NOD2	COX2	257632(Tax:10090)	17709(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2 .
25429073	0	NOD2	72,76	Nod2	25,29	NOD2	Nod2	257632(Tax:10090)	257632(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dobj|Expression	Blau Syndrome-Associated Nod2 Mutation Alters Expression of Full-Length NOD2 and Limits Responses to Muramyl_Dipeptide in Knock-in Mice .
26332444	0	NOD2	45,49	Nucleotide-binding_oligomerization_domain_2	0,43	NOD2	Nucleotide-binding oligomerization domain 2	64127	64127	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Nucleotide-binding_oligomerization_domain_2 -LRB- NOD2 -RRB- activation induces apoptosis of human oral_squamous_cell_carcinoma cells .
18773284	0	NOD2	96,100	TLR2	30,34	NOD2	TLR2	64127	7097	Gene	Gene	stimulation|compound|START_ENTITY expression|nmod|stimulation expression|nmod|END_ENTITY	Higher monocyte expression of TLR2 and TLR4 , and enhanced pro-inflammatory synergy of TLR2 with NOD2 stimulation in sarcoidosis .
22829933	0	NOD2	28,32	TRIM27	0,6	NOD2	TRIM27	64127	5987	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation .
21716313	0	NOD2	90,94	Toll-like_receptor_10	15,36	NOD2	Toll-like receptor 10	64127	81793	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Toll-like_receptor_10 and susceptibility to Crohn 's _ disease independent of NOD2 .
22575870	0	NOD2	32,36	ghrelin	11,18	NOD2	ghrelin	291912(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-kB activation when protects against acute_lung_injury in rats challenged with cecal_ligation_and_puncture .
23872065	0	NOD2	16,20	miR-122	0,7	NOD2	miR-122	64127	406906	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn 's _ disease .
24054330	0	NOD2	25,29	microRNA-29	38,49	NOD2	microRNA-29	64127	407021	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release .
23936340	0	NOD2	117,121	nucleotide-binding_oligomerization_domain_2	72,115	NOD2	nucleotide-binding oligomerization domain 2	64127	64127	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Identification of benzimidazole_diamides as selective inhibitors of the nucleotide-binding_oligomerization_domain_2 -LRB- NOD2 -RRB- signaling pathway .
25746347	0	NOD2	62,66	nucleotide-binding_oligomerization_domain_2	17,60	NOD2	nucleotide-binding oligomerization domain 2	487286(Tax:9615)	487286(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of nucleotide-binding_oligomerization_domain_2 -LRB- NOD2 -RRB- gene in miniature dachshunds with inflammatory colorectal_polyps .
23986775	0	NODAL	33,38	Nodal	9,14	NODAL	Nodal	4838	4838	Gene	Gene	expression|amod|START_ENTITY affects|dobj|expression affects|nsubj|END_ENTITY	Maternal Nodal inversely affects NODAL and STOX1 expression in the fetal placenta .
22503063	0	NOG	34,37	Noggin	26,32	NOG	Noggin	9241	9241	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular analysis of the Noggin -LRB- NOG -RRB- gene in holoprosencephaly patients .
19699797	0	NOGO-A	30,36	GPR50	0,5	NOGO-A	GPR50	57142	9248	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth .
23085760	0	NOL7	27,31	thrombospondin-1	65,81	NOL7	thrombospondin-1	51406	7057	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression .
19541936	0	NOLC1	0,5	TP53	77,81	NOLC1	TP53	70769(Tax:10090)	22059(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	NOLC1 , an enhancer of nasopharyngeal_carcinoma progression , is essential for TP53 to regulate MDM2 expression .
17965019	0	NOM1	0,4	protein_phosphatase_I	13,34	NOM1	protein phosphatase I	64434	5464	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	NOM1 targets protein_phosphatase_I to the nucleolus .
25998385	0	NONO	88,92	SFPQ	82,86	NONO	SFPQ	4841	654780	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Characterization of DNA binding and pairing activities associated with the native SFPQ __ NONO DNA repair protein complex .
15664818	0	NOP	75,78	ORL1	69,73	NOP	ORL1	4987	4987	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Synthesis and SAR studies of 3-phenoxypropyl_piperidine analogues as ORL1 -LRB- NOP -RRB- receptor agonists .
15571866	0	NOP	185,188	nociceptin_receptor	164,183	NOP	nociceptin receptor	4987	4987	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	A new synthetic approach of N - -LRB- 4-amino-2-methylquinolin-6-yl -RRB- -2 - -LRB- 4-ethylphenoxymethyl -RRB- benzamide -LRB- JTC-801 -RRB- and its analogues and their pharmacological evaluation as nociceptin_receptor -LRB- NOP -RRB- antagonists .
12709428	0	NOR-1	47,52	AF-1	4,8	NOR-1	AF-1	8013	3460	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation , coactivator recruitment , and activation by the purine anti-metabolite 6-mercaptopurine .
12788080	0	NOR-1	56,61	Parathyroid_hormone	0,19	NOR-1	Parathyroid hormone	18124(Tax:10090)	19226(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Parathyroid_hormone induces the nuclear orphan receptor NOR-1 in osteoblasts .
19720740	0	NOR-1	31,36	hypoxia-inducible_factor_1	4,30	NOR-1	hypoxia-inducible factor 1	8013	3091	Gene	Gene	axis|compound|START_ENTITY regulates|nsubj|axis END_ENTITY|parataxis|regulates	The hypoxia-inducible_factor_1 / NOR-1 axis regulates the survival response of endothelial cells to hypoxia .
9573341	0	NOR-1	83,88	neuron-derived_orphan_receptor-1	49,81	NOR-1	neuron-derived orphan receptor-1	8013	8013	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Alternative splicing generates isoforms of human neuron-derived_orphan_receptor-1 -LRB- NOR-1 -RRB- mRNA .
22155709	0	NOR1	71,75	oxidored_nitro_domain_containing_protein_1	27,69	NOR1	oxidored nitro domain containing protein 1	22038(Tax:10090)	127700	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of oxidored_nitro_domain_containing_protein_1 -LRB- NOR1 -RRB- , in mouse tissues and in normal and cancerous human tissues .
26986513	0	NORE1A	0,6	CD40L	35,40	NORE1A	CD40L	83593	959	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	NORE1A induction by membrane-bound CD40L -LRB- mCD40L -RRB- contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism .
20434789	0	NORE1A	63,69	NORE1A	93,99	NORE1A	NORE1A	83593	83593	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small_cell_lung_carcinoma .
20434789	0	NORE1A	93,99	NORE1A	63,69	NORE1A	NORE1A	83593	83593	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small_cell_lung_carcinoma .
16729964	0	NORPEG	59,65	RAI14	67,72	NORPEG	RAI14	26064	26064	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Cell density-dependent nuclear/cytoplasmic localization of NORPEG -LRB- RAI14 -RRB- protein .
20386492	0	NOS	25,28	Angiotensin_II	0,14	NOS	Angiotensin II	4842	183	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates NOS expression in afferent arterioles of the developing porcine kidney .
10666024	0	NOS	99,102	ICAM-1	32,38	NOS	ICAM-1	4843	3383	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Hyperbaric_oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia : the role of NOS .
25066694	0	NOS	158,161	NOX4	124,128	NOS	NOX4	18125(Tax:10090)	50490(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Netrin-1 abrogates ischemia/reperfusion-induced cardiac_mitochondrial_dysfunction via nitric_oxide-dependent attenuation of NOX4 activation and recoupling of NOS .
24713495	0	NOS	23,26	Nitric_oxide_synthase	0,21	NOS	Nitric oxide synthase	4842	4842	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Nitric_oxide_synthase -LRB- NOS -RRB- single nucleotide polymorphisms are associated with coronary_heart_disease and hypertension in the INTERGENE study .
11166745	0	NOS	33,36	nitric_oxide_synthase	10,31	NOS	nitric oxide synthase	4843	4843	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Placental nitric_oxide_synthase -LRB- NOS -RRB- activity and nitric_oxide -LRB- NO -RRB- production in normal pregnancy , pre-eclampsia and eclampsia .
24755185	0	NOS	45,48	nitric_oxide_synthase	22,43	NOS	nitric oxide synthase	4842	4842	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of nitric_oxide_synthase -LRB- NOS -RRB- isoforms in ovarian follicles of the catfish , Clarias batrachus and its relation with ovarian activity .
25680459	0	NOS	40,43	nitric_oxide_synthase	17,38	NOS	nitric oxide synthase	4843	4843	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Flavone inhibits nitric_oxide_synthase -LRB- NOS -RRB- activity , nitric_oxide production and protein S-nitrosylation in breast_cancer cells .
8525486	0	NOS	67,70	nitric_oxide_synthase	44,65	NOS	nitric oxide synthase	4843	4843	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effect of methylmercury -LRB- CH3HgCl -RRB- injury on nitric_oxide_synthase -LRB- NOS -RRB- activity in cultured human umbilical vascular endothelial cells .
10581471	0	NOS-1	57,62	nitric_oxide_synthase	34,55	NOS-1	nitric oxide synthase	4842	4842	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cellular localization of neuronal nitric_oxide_synthase -LRB- NOS-1 -RRB- in the human and rat retina .
10719359	0	NOS-2	39,44	nitric_oxide_synthase-2	14,37	NOS-2	nitric oxide synthase-2	4843	4843	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of nitric_oxide_synthase-2 -LRB- NOS-2 -RRB- in reactive astrocytes of the human glaucomatous_optic_nerve head .
26861996	0	NOS-I	31,36	NOS1AP	15,21	NOS-I	NOS1AP	18125(Tax:10090)	9722	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Interaction of NOS1AP with the NOS-I PDZ domain : Implications for schizophrenia-related alterations in dendritic morphology .
22579290	0	NOS1	52,56	FMRP	60,64	NOS1	FMRP	4842	57532	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex .
22798524	0	NOS1	68,72	GTP_cyclohydrolase_1	14,34	NOS1	GTP cyclohydrolase 1	4842	2643	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Cardiomyocyte GTP_cyclohydrolase_1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation .
25168001	0	NOS1	66,70	PACAP	0,5	NOS1	PACAP	4842	116	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting .
11023998	0	NOS1	56,60	bcl-2	30,35	NOS1	bcl-2	4842	596	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Preconditioning regulation of bcl-2 and p66shc by human NOS1 enhances tolerance to oxidative stress .
10966937	0	NOS1	40,44	nitric_oxide_synthase	17,38	NOS1	nitric oxide synthase	24598(Tax:10116)	24598(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of neuronal nitric_oxide_synthase -LRB- NOS1 -RRB- in the pathogenesis of renal hemodynamic changes in diabetes .
17565224	0	NOS1AP	45,51	CAPON	53,58	NOS1AP	CAPON	9722	9722	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations between genetic variants in the NOS1AP -LRB- CAPON -RRB- gene and cardiac repolarization in the old order Amish .
19077434	0	NOS1AP	27,33	CAPON	35,40	NOS1AP	CAPON	9722	9722	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence for a role of the NOS1AP -LRB- CAPON -RRB- gene in schizophrenia and its clinical dimensions : an association study in a South American population isolate .
26861996	0	NOS1AP	15,21	NOS-I	31,36	NOS1AP	NOS-I	9722	18125(Tax:10090)	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	Interaction of NOS1AP with the NOS-I PDZ domain : Implications for schizophrenia-related alterations in dendritic morphology .
25918243	0	NOS1AP	0,6	YAP	36,39	NOS1AP	YAP	9722	10413	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	NOS1AP functionally associates with YAP to regulate Hippo signaling .
25918243	0	NOS1AP	0,6	YAP	36,39	NOS1AP	YAP	9722	10413	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	NOS1AP functionally associates with YAP to regulate Hippo signaling .
15922861	0	NOS2	25,29	Nitric_oxide_synthase_2	0,23	NOS2	Nitric oxide synthase 2	4843	4843	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Nitric_oxide_synthase_2 -LRB- NOS2 -RRB- promoter polymorphisms in colorectal_cancer .
10593859	0	NOS2	72,76	nitric_oxide_synthase	49,70	NOS2	nitric oxide synthase	4843	4843	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of the expression of the inflammatory nitric_oxide_synthase -LRB- NOS2 -RRB- by cyclic_AMP .
19859740	0	NOS2	57,61	nitric_oxide_synthase	27,48	NOS2	nitric oxide synthase	4843	4843	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Malaria severity and human nitric_oxide_synthase type 2 -LRB- NOS2 -RRB- promoter haplotypes .
8577713	0	NOS2	69,73	nitric_oxide_synthase	46,67	NOS2	nitric oxide synthase	4843	4843	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of human inducible nitric_oxide_synthase -LRB- NOS2 -RRB- gene by cytokines : initial analysis of the human NOS2 promoter .
17720813	0	NOS2	0,4	p65	51,54	NOS2	p65	4843	5970	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	NOS2 regulation of NF-kappaB by S-nitrosylation of p65 .
15275951	0	NOS2A	58,63	inducible_nitric_oxide_synthase	20,51	NOS2A	inducible nitric oxide synthase	4843	4843	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation of an inducible_nitric_oxide_synthase gene -LRB- NOS2A -RRB- polymorphism in a multiple_sclerosis population .
18931031	0	NOS3	14,18	Akt	0,3	NOS3	Akt	4846	207	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Akt activates NOS3 and separately restores barrier integrity in H2O2-stressed human cardiac microvascular endothelium .
19570880	0	NOS3	35,39	Akt1	0,4	NOS3	Akt1	18127(Tax:10090)	11651(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs .
27039718	0	NOS3	17,21	MDR1	23,27	NOS3	MDR1	4846	5243	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|appos|END_ENTITY	Effects of TNFa , NOS3 , MDR1 Gene Polymorphisms on Clinical Parameters , Prognosis and Survival of Multiple_Myeloma Cases .
15492314	0	NOS3	78,82	endothelial_nitric_oxide_synthase	43,76	NOS3	endothelial nitric oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Cardiomyocyte-restricted overexpression of endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction .
18468205	0	NOS3	99,103	endothelial_nitric_oxide_synthase	64,97	NOS3	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of evidence for contribution of intron4a/b polymorphism of endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- gene to plasma nitric_oxide levels .
20367485	0	NOS3	57,61	endothelial_nitric_oxide_synthase	17,50	NOS3	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A variant of the endothelial_nitric_oxide_synthase gene -LRB- NOS3 -RRB- associated with AMS susceptibility is less common in the Quechua , a high altitude Native population .
7514568	0	NOS3	87,91	endothelial_nitric_oxide_synthase	52,85	NOS3	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and chromosomal localization of the human endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- gene .
20299462	0	NOS3	125,129	nitric-oxide_synthase_3	100,123	NOS3	nitric-oxide synthase 3	4846	4846	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Angiotensin_II stimulates thick ascending limb NO production via AT -LRB- 2 -RRB- receptors and Akt1-dependent nitric-oxide_synthase_3 -LRB- NOS3 -RRB- activation .
25956856	0	NOS3	94,98	nitric_oxide_synthase	71,92	NOS3	nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Functional G894T -LRB- rs1799983 -RRB- polymorphism and intron-4 VNTR variant of nitric_oxide_synthase -LRB- NOS3 -RRB- gene are susceptibility biomarkers of obesity among Tunisians .
9270610	0	NOS3	82,86	nitric_oxide_synthase	59,80	NOS3	nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Migraine association and linkage studies of an endothelial nitric_oxide_synthase -LRB- NOS3 -RRB- gene polymorphism .
15755735	0	NOS3AS	45,51	Endothelial_nitric-oxide_synthase_antisense	0,43	NOS3AS	Endothelial nitric-oxide synthase antisense	285973	285973	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Endothelial_nitric-oxide_synthase_antisense -LRB- NOS3AS -RRB- gene encodes an autophagy-related protein -LRB- APG9-like2 -RRB- highly expressed in trophoblast .
9201025	0	NOS_3	119,124	endothelial_nitric_oxide_synthase	84,117	NOS 3	endothelial nitric oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial_nitric_oxide_synthase -LRB- NOS_3 -RRB- gene .
16039607	0	NOT2	46,50	cyclin-dependent_kinase_11	4,30	NOT2	cyclin-dependent kinase 11	4848	23097	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The cyclin-dependent_kinase_11 interacts with NOT2 .
12207886	0	NOT3	83,87	TBP-interacting_protein_120B	0,28	NOT3	TBP-interacting protein 120B	4849	67088(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	TBP-interacting_protein_120B , which is induced in relation to myogenesis , binds to NOT3 .
9428412	0	NOTCH	102,107	SUP-17	0,6	NOTCH	SUP-17	31293(Tax:7227)	172689(Tax:6239)	Gene	Gene	signalling|nsubj|START_ENTITY END_ENTITY|parataxis|signalling	SUP-17 , a Caenorhabditis_elegans ADAM protein related to Drosophila KUZBANIAN , and its role in LIN-12 / NOTCH signalling .
21679465	0	NOTCH-1	0,7	PEA3	46,50	NOTCH-1	PEA3	4851	2118	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast_cancer : novel therapeutic implications .
24308033	0	NOTCH1	41,47	CCN3	26,30	NOTCH1	CCN3	4851	4856	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The matricellular protein CCN3 regulates NOTCH1 signalling in chronic_myeloid_leukaemia .
23108395	0	NOTCH1	42,48	DDX5	0,4	NOTCH1	DDX5	4851	1655	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T_cell_acute_lymphoblastic_leukemia .
22038626	0	NOTCH1	0,6	E-cadherin	64,74	NOTCH1	E-cadherin	4851	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|repression repression|amod|END_ENTITY	NOTCH1 regulates migration and invasion of skin_cancer cells by E-cadherin repression .
20861909	0	NOTCH1	0,6	FBXW7	14,19	NOTCH1	FBXW7	4851	55294	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell_acute_lymphoblastic_leukemia patients treated on DCOG or COALL protocols .
22110129	0	NOTCH1	57,63	Jarid2	0,6	NOTCH1	Jarid2	18128(Tax:10090)	16468(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Jarid2 -LRB- Jumonji , AT rich interactive domain 2 -RRB- regulates NOTCH1 expression via histone modification in the developing heart .
26864323	0	NOTCH1	23,29	MMP9	43,47	NOTCH1	MMP9	18128(Tax:10090)	17395(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic_Acid-free fatty_acid in colon_cancer cells .
26330272	0	NOTCH1	29,35	NALT	7,11	NOTCH1	NALT	4851	101928483	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute_lymphoblastic_leukemia .
17114293	0	NOTCH1	0,6	c-MYC	26,31	NOTCH1	c-MYC	4851	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth .
19995395	0	NOTCH2	0,6	CD23	57,61	NOTCH2	CD23	4853	2208	Gene	Gene	links|nsubj|START_ENTITY links|nmod|expression expression|nmod|END_ENTITY	NOTCH2 links protein_kinase_C_delta to the expression of CD23 in chronic_lymphocytic_leukaemia -LRB- CLL -RRB- cells .
19995395	0	NOTCH2	0,6	protein_kinase_C_delta	13,35	NOTCH2	protein kinase C delta	4853	5580	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	NOTCH2 links protein_kinase_C_delta to the expression of CD23 in chronic_lymphocytic_leukaemia -LRB- CLL -RRB- cells .
25578324	0	NOTCH3	76,82	BGN	36,39	NOTCH3	BGN	4854	633	Gene	Gene	Accumulates|nmod|START_ENTITY Accumulates|nsubj|END_ENTITY	The Small Leucine-Rich Proteoglycan BGN Accumulates in CADASIL and Binds to NOTCH3 .
24525742	0	NOTCH3	0,6	MUSASHI-1	27,36	NOTCH3	MUSASHI-1	4854	4440	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling regulates|dobj|expression expression|compound|END_ENTITY	NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal_cancer cells .
21551231	0	NOTCH3	76,82	miR-150	86,93	NOTCH3	miR-150	4854	406942	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Modulation of microRNA expression in human T-cell development : targeting of NOTCH3 by miR-150 .
15345329	0	NOV	35,38	Nephroblastoma_overexpressed_gene	0,33	NOV	Nephroblastoma overexpressed gene	81526(Tax:10116)	81526(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nephroblastoma_overexpressed_gene -LRB- NOV -RRB- expression in rat hepatic stellate cells .
26922803	0	NOVA1	49,54	Neuro-oncological_Ventral_Antigen_1	12,47	NOVA1	Neuro-oncological Ventral Antigen 1	4857	4857	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Upregulated Neuro-oncological_Ventral_Antigen_1 -LRB- NOVA1 -RRB- Expression Is Specific to Mature and Immature T - and NK-Cell Lymphomas .
14519668	0	NOVH	0,4	MMP3	15,19	NOVH	MMP3	4856	4314	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism .
15491278	0	NOX1	40,44	ATF-1	18,23	NOX1	ATF-1	114243(Tax:10116)	315305(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Essential role of ATF-1 in induction of NOX1 , a catalytic subunit of NADPH oxidase : involvement of mitochondrial respiratory chain .
18005670	0	NOX1	14,18	GATA	33,37	NOX1	GATA	27035	55278	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Regulation of NOX1 expression by GATA , HNF-1alpha , and Cdx transcription factors .
22549734	0	NOX1	92,96	NADPH_oxidase_1	75,90	NOX1	NADPH oxidase 1	237038(Tax:10090)	237038(Tax:10090)	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	The p47phox - _ and_NADPH_oxidase_organiser_1 -LRB- NOXO1 -RRB- - dependent activation of NADPH_oxidase_1 -LRB- NOX1 -RRB- mediates endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- uncoupling and endothelial_dysfunction in a streptozotocin-induced murine model of diabetes .
26753853	0	NOX1	25,29	NADPH_oxidase_1	8,23	NOX1	NADPH oxidase 1	27035	27035	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of NADPH_oxidase_1 -LRB- NOX1 -RRB- in gut inflammation .
26674464	0	NOX1	49,53	NOX2	55,59	NOX1	NOX2	114243(Tax:10116)	66021(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Decreased reactive oxygen species production and NOX1 , NOX2 , NOX4 expression contribute to hyporeactivity to phenylephrine in aortas of pregnant SHR .
26674464	0	NOX1	49,53	NOX4	61,65	NOX1	NOX4	114243(Tax:10116)	85431(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Decreased reactive oxygen species production and NOX1 , NOX2 , NOX4 expression contribute to hyporeactivity to phenylephrine in aortas of pregnant SHR .
23119229	0	NOX2	75,79	NADPH_oxidase	61,74	NOX2	NADPH oxidase	1536	1536	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Phosphorylation of p47phox is required for receptor-mediated NADPH_oxidase / NOX2 activation in Epstein-Barr_virus-transformed human B lymphocytes .
22493499	0	NOX2	115,119	NADPH_oxidase_2	98,113	NOX2	NADPH oxidase 2	13058(Tax:10090)	13058(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Receptor signaling_lymphocyte-activation_molecule_family_1 -LRB- Slamf1 -RRB- regulates membrane fusion and NADPH_oxidase_2 -LRB- NOX2 -RRB- activity by recruiting a Beclin-1 / Vps34/ultraviolet _ radiation_resistance-associated_gene -LRB- UVRAG -RRB- complex .
18453612	0	NOX2	13,17	NF-kappaB	89,98	NOX2	NF-kappaB	1536	4790	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|nmod|END_ENTITY	Dual role of NOX2 in respiratory_syncytial_virus - and sendai_virus-induced activation of NF-kappaB in airway epithelial cells .
26674464	0	NOX2	55,59	NOX1	49,53	NOX2	NOX1	66021(Tax:10116)	114243(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Decreased reactive oxygen species production and NOX1 , NOX2 , NOX4 expression contribute to hyporeactivity to phenylephrine in aortas of pregnant SHR .
26674464	0	NOX2	55,59	NOX4	61,65	NOX2	NOX4	66021(Tax:10116)	85431(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Decreased reactive oxygen species production and NOX1 , NOX2 , NOX4 expression contribute to hyporeactivity to phenylephrine in aortas of pregnant SHR .
26029782	0	NOX2	102,106	gp91phox	108,116	NOX2	gp91phox	66021(Tax:10116)	66021(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fluorofenidone attenuates oxidative stress and renal_fibrosis in obstructive_nephropathy via blocking NOX2 -LRB- gp91phox -RRB- expression and inhibiting ERK/MAPK signaling pathway .
23119229	0	NOX2	75,79	p47phox	19,26	NOX2	p47phox	1536	653361	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of p47phox is required for receptor-mediated NADPH_oxidase / NOX2 activation in Epstein-Barr_virus-transformed human B lymphocytes .
22399808	0	NOX2	21,25	urotensin-II	56,68	NOX2	urotensin-II	13058(Tax:10090)	24111(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II .
21965295	0	NOX4	0,4	FoxO3a	28,34	NOX4	FoxO3a	50490(Tax:10090)	56484(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	NOX4 mediates activation of FoxO3a and matrix_metalloproteinase-2 expression by urotensin-II .
25066694	0	NOX4	124,128	NOS	158,161	NOX4	NOS	50490(Tax:10090)	18125(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Netrin-1 abrogates ischemia/reperfusion-induced cardiac_mitochondrial_dysfunction via nitric_oxide-dependent attenuation of NOX4 activation and recoupling of NOS .
26674464	0	NOX4	61,65	NOX1	49,53	NOX4	NOX1	85431(Tax:10116)	114243(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Decreased reactive oxygen species production and NOX1 , NOX2 , NOX4 expression contribute to hyporeactivity to phenylephrine in aortas of pregnant SHR .
26674464	0	NOX4	61,65	NOX2	55,59	NOX4	NOX2	85431(Tax:10116)	66021(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Decreased reactive oxygen species production and NOX1 , NOX2 , NOX4 expression contribute to hyporeactivity to phenylephrine in aortas of pregnant SHR .
26731985	0	NOX4	63,67	apoE	71,75	NOX4	apoE	50490(Tax:10090)	11816(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Mice Mice|amod|END_ENTITY	miR-31 Overexpression Exacerbates Atherosclerosis by Targeting NOX4 in apoE -LRB- - / - -RRB- Mice .
26986073	0	NOX4	96,100	miR-99a	0,7	NOX4	miR-99a	50507	407055	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-99a regulates ROS-mediated invasion and migration_of_lung_adenocarcinoma cells by targeting NOX4 .
21965295	0	NOX4	0,4	urotensin-II	80,92	NOX4	urotensin-II	50490(Tax:10090)	24111(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	NOX4 mediates activation of FoxO3a and matrix_metalloproteinase-2 expression by urotensin-II .
18160052	0	NOX5	36,40	c-Abl	64,69	NOX5	c-Abl	79400	25	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl .
22361683	0	NOXA	0,4	MCL-1	126,131	NOXA	MCL-1	5366	4170	Gene	Gene	degraded|nsubjpass|START_ENTITY degraded|nmod|pathway pathway|acl:relcl|blocked blocked|nmod|END_ENTITY	NOXA , a sensor of proteasome integrity , is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1 .
22525702	0	NOXA	83,87	Mcl-1	0,5	NOXA	Mcl-1	5366	4170	Gene	Gene	expression|compound|START_ENTITY overcome|nmod|expression resistance|acl:relcl|overcome defines|dobj|resistance defines|nsubj|Phosphorylation Phosphorylation|compound|END_ENTITY	Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells .
18929641	0	NOXO1	86,91	NADPH_oxidase_organizer_1	59,84	NOXO1	NADPH oxidase organizer 1	124056	124056	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tumor_necrosis_factor_alpha activates transcription of the NADPH_oxidase_organizer_1 -LRB- NOXO1 -RRB- gene and upregulates superoxide production in colon epithelial cells .
16513643	0	NP-1	172,176	KDR	180,183	NP-1	KDR	8829	3791	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Characterization of a bicyclic peptide neuropilin-1 -LRB- NP-1 -RRB- antagonist -LRB- EG3287 -RRB- reveals importance of vascular_endothelial_growth_factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling .
22745372	0	NP1	16,19	IFN-b	29,34	NP1	IFN-b	4884	3456	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Human_bocavirus NP1 inhibits IFN-b production by blocking association of IFN regulatory factor 3 with IFNB promoter .
16352664	0	NP60	16,20	p38	31,34	NP60	p38	84656	1432	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Nuclear protein NP60 regulates p38 MAPK activity .
25444159	0	NPAS2	67,72	Drd3	29,33	NPAS2	Drd3	18143(Tax:10090)	13490(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Direct regulation of diurnal Drd3 expression and cocaine reward by NPAS2 .
23430855	0	NPC1	40,44	MG132	69,74	NPC1	MG132	4864	875581(Tax:243273)	Gene	Gene	Mutations|compound|START_ENTITY Mutations|nmod|END_ENTITY	Treatment of Human Fibroblasts Carrying NPC1 Missense Mutations with MG132 Leads to an Improvement of Intracellular Cholesterol Trafficking .
15908696	0	NPC1	50,54	Niemann-Pick_C1	33,48	NPC1	Niemann-Pick C1	4864	4864	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The sterol-sensing domain of the Niemann-Pick_C1 -LRB- NPC1 -RRB- protein regulates trafficking of low density lipoprotein cholesterol .
19229602	0	NPC1	46,50	Niemann-Pick_C1	21,36	NPC1	Niemann-Pick C1	4864	4864	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	NO-1886 up-regulates Niemann-Pick_C1 protein -LRB- NPC1 -RRB- expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
20953676	0	NPC1L1	6,12	PPARa	51,56	NPC1L1	PPARa	29881	5465	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Human NPC1L1 expression is positively regulated by PPARa .
11042687	0	NPDC-1	0,6	E2F-1	85,90	NPDC-1	E2F-1	56654	1869	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	NPDC-1 , a regulator of neural cell proliferation and differentiation , interacts with E2F-1 , reduces its binding to DNA and modulates its transcriptional activity .
17107711	0	NPFF	29,33	neuropeptide_FF	12,27	NPFF	neuropeptide FF	60337(Tax:10116)	60337(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of neuropeptide_FF -LRB- NPFF -RRB- in the expression of sensitization to hyperlocomotor effect of morphine and ethanol .
18276024	0	NPFF	31,35	neuropeptide_FF	14,29	NPFF	neuropeptide FF	54615(Tax:10090)	54615(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of neuropeptide_FF -LRB- NPFF -RRB- - induced hypothermia and anti-morphine analgesia by RF9 , a new selective NPFF receptors antagonist .
20381562	0	NPFF	33,37	neuropeptide_FF	16,31	NPFF	neuropeptide FF	60337(Tax:10116)	60337(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of neuropeptide_FF -LRB- NPFF -RRB- receptors in correlation with morphine-induced reward in the rat brain .
22197492	0	NPFF	31,35	neuropeptide_FF	14,29	NPFF	neuropeptide FF	60337(Tax:10116)	60337(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Modulation of neuropeptide_FF -LRB- NPFF -RRB- receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats .
15121216	0	NPFF2	34,39	neuropeptide_FF	40,55	NPFF2	neuropeptide FF	104443(Tax:10090)	104443(Tax:10090)	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	Opposite alterations of NPFF1 and NPFF2 neuropeptide_FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains .
22375000	0	NPFF2	125,130	neuropeptide_FF	108,123	NPFF2	neuropeptide FF	10886	10886	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	GRK2 protein-mediated transphosphorylation contributes to loss of function of - opioid receptors induced by neuropeptide_FF -LRB- NPFF2 -RRB- receptors .
21689635	0	NPHP-8	39,45	RPGRIP1L	70,78	NPHP-8	RPGRIP1L	23322	23322	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Caenorhabditis_elegans ciliary protein NPHP-8 , the homologue of human RPGRIP1L , is required for ciliogenesis and chemosensation .
18218308	0	NPHP2	21,26	INVS	15,19	NPHP2	INVS	27130	27130	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Association of INVS -LRB- NPHP2 -RRB- mutation in an adolescent exhibiting nephronophthisis -LRB- NPH -RRB- and complete situs inversus .
16909394	0	NPHP6	25,30	CEP290	17,23	NPHP6	CEP290	80184	80184	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the CEP290 -LRB- NPHP6 -RRB- gene are a frequent cause of Leber_congenital_amaurosis .
17564974	0	NPHP6	31,36	CEP290	23,29	NPHP6	CEP290	80184	80184	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Pleiotropic effects of CEP290 -LRB- NPHP6 -RRB- mutations extend to Meckel_syndrome .
15086927	0	NPHS1	14,19	Nephrin	0,7	NPHS1	Nephrin	4868	4868	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Nephrin gene -LRB- NPHS1 -RRB- in patients with minimal change nephrotic_syndrome -LRB- MCNS -RRB- .
19562271	0	NPHS2	43,48	Lmx1b	53,58	NPHS2	Lmx1b	7827	4010	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	The transcriptional regulation of podocin -LRB- NPHS2 -RRB- by Lmx1b and a promoter single nucleotide polymorphism .
7831767	0	NPI-1	0,5	SRP-1	28,33	NPI-1	SRP-1	3836	3836	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	NPI-1 , the human homolog of SRP-1 , interacts with influenza virus nucleoprotein .
18728180	0	NPL-4	48,53	CDC-48UFD-1	36,47	NPL-4	CDC-48UFD-1	852468(Tax:4932)	851431(Tax:4932)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Cell cycle progression requires the CDC-48UFD-1 / NPL-4 complex for efficient DNA replication .
9028963	0	NPM	83,86	ALK	41,44	NPM	ALK	4869	238	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Detection of anaplastic_lymphoma kinase -LRB- ALK -RRB- and nucleolar protein nucleophosmin -LRB- NPM -RRB- - ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1 .
15144954	0	NPM	18,21	HDM2	37,41	NPM	HDM2	4869	4193	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation .
24793791	0	NPM	47,50	STAT3	15,20	NPM	STAT3	4869	6774	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer .
19775300	0	NPM	77,80	STAT5	47,52	NPM	STAT5	4869	6776	Gene	Gene	mutations|compound|START_ENTITY expression|nmod|mutations expression|nmod|END_ENTITY	FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations .
9092633	0	NPM	63,66	nucleophosmin/B23	44,61	NPM	nucleophosmin/B23	4869	4869	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the human nucleophosmin/B23 -LRB- NPM -RRB- gene : identification of the YY1 binding site at the 5 ' enhancer region .
22099964	0	NPM-1	38,43	nucleophosmin	23,36	NPM-1	nucleophosmin	4869	4869	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel mutations of the nucleophosmin -LRB- NPM-1 -RRB- gene in Egyptian patients with acute_myeloid_leukemia : a pilot study .
22712502	0	NPM1	57,61	Erythroid_differentiation-associated_gene	0,41	NPM1	Erythroid differentiation-associated gene	4869	55363	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Erythroid_differentiation-associated_gene interacts with NPM1 -LRB- nucleophosmin/B23 -RRB- and increases its protein stability , resisting cell apoptosis .
17768124	0	NPM1	0,4	FLT3	36,40	NPM1	FLT3	4869	2322	Gene	Gene	mutations|compound|START_ENTITY stable|nsubj|mutations stable|nmod|mutations mutations|nummod|END_ENTITY	NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute_myeloid_leukemia .
17957027	0	NPM1	96,100	FLT3	14,18	NPM1	FLT3	4869	2322	Gene	Gene	mutations|nummod|START_ENTITY level|nmod|mutations mutant|dobj|level mutant|nsubj|impact impact|nmod|duplication duplication|compound|END_ENTITY	The impact of FLT3 internal tandem duplication mutant level , number , size , and interaction with NPM1 mutations in a large cohort of young adult patients with acute_myeloid_leukemia .
20567020	0	NPM1	166,170	FLT3	188,192	NPM1	FLT3	4869	2322	Gene	Gene	mutation|compound|START_ENTITY acute_myeloid_leukemia|nmod|mutation confer|nmod|acute_myeloid_leukemia confer|nmod|duplication duplication|compound|END_ENTITY	IDH1 and IDH2 mutations are frequent genetic alterations in acute_myeloid_leukemia and confer adverse prognosis in cytogenetically normal acute_myeloid_leukemia with NPM1 mutation without FLT3 internal tandem duplication .
21338238	0	NPM1	53,57	FLT3	26,30	NPM1	FLT3	4869	2322	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Fms like tyrosine kinase -LRB- FLT3 -RRB- and nucleophosmin_1 -LRB- NPM1 -RRB- mutations in de novo normal karyotype acute_myeloid_leukemia -LRB- AML -RRB- .
26410460	0	NPM1	30,34	FLT3	36,40	NPM1	FLT3	4869	2322	Gene	Gene	+|compound|START_ENTITY +|dep|END_ENTITY	Prognostic impact of combined NPM1 + / FLT3 - genotype in patients with acute_myeloid_leukemia with intermediate risk cytogenetics stratified by age and treatment modalities .
26405153	0	NPM1	124,128	Nucleophosmin-1	107,122	NPM1	Nucleophosmin-1	4869	4869	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Allogeneic hematopoietic cell transplantation in acute_myeloid_leukemia with normal karyotype and isolated Nucleophosmin-1 -LRB- NPM1 -RRB- mutation : outcome strongly correlates with disease status .
17488663	0	NPM1	58,62	nucleophosmin	43,56	NPM1	nucleophosmin	4869	4869	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Translocations and mutations involving the nucleophosmin -LRB- NPM1 -RRB- gene in lymphomas and leukemias .
21791474	0	NPM1	88,92	nucleophosmin	73,86	NPM1	nucleophosmin	4869	4869	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	High CD33 expression levels in acute_myeloid_leukemia cells carrying the nucleophosmin -LRB- NPM1 -RRB- mutation .
12498389	0	NPP-2	25,30	autotaxin	14,23	NPP-2	autotaxin	5168	5168	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of autotaxin -LRB- NPP-2 -RRB- is closely linked to invasiveness of breast_cancer cells .
15677494	0	NPP1	65,69	insulin_receptor	32,48	NPP1	insulin receptor	5167	3643	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Increased hepatic levels of the insulin_receptor inhibitor , PC-1 / NPP1 , induce insulin resistance and glucose_intolerance .
17343213	0	NPPB	58,62	natriuretic_peptide_precursor_B	25,56	NPPB	natriuretic peptide precursor B	4879	4879	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the natriuretic_peptide_precursor_B -LRB- NPPB -RRB- gene in patients with hypertrophic_cardiomyopathy .
7698765	0	NPPC	140,144	CNP	130,133	NPPC	CNP	4880	12799(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and chromosomal assignment of the mouse C-type_natriuretic_peptide _ -LRB- CNP -RRB- gene -LRB- Nppc -RRB- : comparison with the human CNP gene -LRB- NPPC -RRB- .
18848850	0	NPR-B	61,66	C-type_natriuretic_peptide	14,40	NPR-B	C-type natriuretic peptide	4882	4880	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of C-type_natriuretic_peptide and of its receptor NPR-B in normal and failing heart .
20595933	0	NPR-B	0,5	C-type_natriuretic_peptide	11,37	NPR-B	C-type natriuretic peptide	230103(Tax:10090)	4880	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	NPR-B , the C-type_natriuretic_peptide specific receptor , is the predominant biological receptor in mouse and pig myocardial tissue .
25012822	0	NPR-B	92,97	C-type_natriuretic_peptide	55,81	NPR-B	C-type natriuretic peptide	230103(Tax:10090)	4880	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Mutant phenotype analysis suggests potential roles for C-type_natriuretic_peptide receptor -LRB- NPR-B -RRB- in male mouse fertility .
8951595	0	NPR-C	84,89	natriuretic_peptide_clearance_receptor	44,82	NPR-C	natriuretic peptide clearance receptor	25339(Tax:10116)	25339(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression and glucocorticoid regulation of natriuretic_peptide_clearance_receptor -LRB- NPR-C -RRB- mRNA in rat brain and choroid plexus .
15149737	0	NPR-C	80,85	natriuretic_peptide_receptor_C	48,78	NPR-C	natriuretic peptide receptor C	4883	4883	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclic_adenosine_monophosphate -LRB- cAMP -RRB- increases natriuretic_peptide_receptor_C -LRB- NPR-C -RRB- expression in human aortic smooth muscle cells .
24259409	0	NPR2	103,107	natriuretic_peptide_receptor_2	71,101	NPR2	natriuretic peptide receptor 2	4882	4882	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Overgrowth_syndrome associated with a gain-of-function mutation of the natriuretic_peptide_receptor_2 -LRB- NPR2 -RRB- gene .
23493048	0	NPR3	37,41	Natriuretic_peptide_receptor-3	0,30	NPR3	Natriuretic peptide receptor-3	4883	4883	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Natriuretic_peptide_receptor-3 gene -LRB- NPR3 -RRB- : nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation .
21464461	0	NPR3	50,54	natriuretic_peptide_clearance_receptor	10,48	NPR3	natriuretic peptide clearance receptor	4883	4883	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Impact of natriuretic_peptide_clearance_receptor -LRB- NPR3 -RRB- gene variants on blood pressure in type 2 diabetes .
20154027	0	NPRL2	50,55	Npr2	0,4	NPRL2	Npr2	10641	856647(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Npr2 , yeast homolog of the human tumor suppressor NPRL2 , is a target of Grr1 required for adaptation to growth on diverse nitrogen sources .
26582740	0	NPRL2	21,26	Raptor	44,50	NPRL2	Raptor	32677(Tax:7227)	31543(Tax:7227)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Amino_acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation .
23372674	0	NPSR1	50,55	Neuropeptide_S_Receptor_1	23,48	NPSR1	Neuropeptide S Receptor 1	387129	387129	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	DNA methylation in the Neuropeptide_S_Receptor_1 -LRB- NPSR1 -RRB- promoter in relation to asthma and environmental factors .
23565190	0	NPSR1	111,116	RORA	74,78	NPSR1	RORA	387129	6095	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Interaction between retinoid_acid receptor-related orphan receptor alpha -LRB- RORA -RRB- and neuropeptide_S_receptor_1 -LRB- NPSR1 -RRB- in asthma .
22078257	0	NPSR1	77,82	neuropeptide_S	47,61	NPSR1	neuropeptide S	387129	594857	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The functional coding variant Asn107Ile of the neuropeptide_S receptor gene -LRB- NPSR1 -RRB- is associated with schizophrenia and modulates verbal memory and the acoustic startle response .
19325992	0	NPSR1	60,65	neuropeptide_S_receptor_1	28,53	NPSR1	neuropeptide S receptor 1	387129	387129	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between neuropeptide_S_receptor_1 gene -LRB- NPSR1 -RRB- and eczema in five European populations .
18068666	0	NPY	64,67	AMPK	27,31	NPY	AMPK	4852	5563	Gene	Gene	neurons|compound|START_ENTITY raises|nmod|neurons raises|dobj|i i|nmod|END_ENTITY	Ghrelin raises -LSB- Ca2 + -RSB- i via AMPK in hypothalamic arcuate nucleus NPY neurons .
24693963	0	NPY	25,28	AMPK	62,66	NPY	AMPK	4852	5563	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Glucocorticoids increase NPY gene expression via hypothalamic AMPK signaling in broiler chicks .
19817504	0	NPY	27,30	AgRP	32,36	NPY	AgRP	24604(Tax:10116)	25582(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
25771084	0	NPY	43,46	CCK-8	35,40	NPY	CCK-8	4852	885	Gene	Gene	-|compound|START_ENTITY -|dep|END_ENTITY	Relative distribution of gastrin - , CCK-8 - , NPY - and CGRP-immunoreactive cells in the digestive tract of dorado -LRB- Salminus brasiliensis -RRB- .
2388526	0	NPY	38,41	CRF	46,49	NPY	CRF	24604(Tax:10116)	81648(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of neuropeptide_Y -LRB- NPY -RRB- on CRF and stress-induced cecal motor response in rats .
25751534	0	NPY	0,3	CRF	41,44	NPY	CRF	109648(Tax:10090)	12917(Tax:10090)	Gene	Gene	inhibits|compound|START_ENTITY extended|nsubj|inhibits extended|ccomp|neurons neurons|nsubj|END_ENTITY	NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking .
9427342	0	NPY	59,62	CRF	14,17	NPY	CRF	24604(Tax:10116)	81648(Tax:10116)	Gene	Gene	BIBP3226|compound|START_ENTITY effect|nmod|BIBP3226 prevents|dobj|effect prevents|nsubj|END_ENTITY	Alpha-helical CRF -LRB- 9-41 -RRB- prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats .
19817504	0	NPY	27,30	IL-6	48,52	NPY	IL-6	24604(Tax:10116)	24498(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
19817504	0	NPY	27,30	MC4R	38,42	NPY	MC4R	24604(Tax:10116)	25635(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|nummod|END_ENTITY	Activation of hypothalamic NPY , AgRP , MC4R , AND IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity .
18468678	0	NPY	11,14	NPY	64,67	NPY	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of NPY and the specific Y1 receptor agonist -LSB- D-His -LRB- 26 -RRB- -RSB- - NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats .
18468678	0	NPY	64,67	NPY	11,14	NPY	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of NPY and the specific Y1 receptor agonist -LSB- D-His -LRB- 26 -RRB- -RSB- - NPY on the deficit in brain reward function and somatic signs associated with nicotine withdrawal in rats .
24965867	0	NPY	118,121	Neuropeptide_Y	102,116	NPY	Neuropeptide Y	4852	4852	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Distribution of peptidergic populations in the human dentate gyrus -LRB- Somatostatin -LSB- SOM-28 , SOM-12 -RSB- and Neuropeptide_Y -LSB- NPY -RSB- -RRB- during postnatal development .
27016395	0	NPY	95,98	Neuropeptide_Y	0,14	NPY	Neuropeptide Y	4852	4852	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|dep|levels	Neuropeptide_Y -LRB- NPY -RRB- in cerebrospinal fluid from patients with Huntington 's _ Disease : increased NPY levels and differential degradation of the NPY1-30 fragment .
27023421	0	NPY	62,65	Neuropeptide_Y	0,14	NPY	Neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY inhibits|nmod|receptor inhibits|nsubj|END_ENTITY	Neuropeptide_Y inhibits the trigeminovascular pathway through NPY Y1 receptor : implications for migraine .
16136022	0	NPY	53,56	leptin	26,32	NPY	leptin	4852	3952	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Prospective evaluation of leptin and neuropeptide_Y -LRB- NPY -RRB- serum levels in girls with anorexia_nervosa .
10921011	0	NPY	24,27	neuropeptide_Y	8,22	NPY	neuropeptide Y	4852	4852	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Plasma neuropeptide_Y -LRB- NPY -RRB- levels in patients with gastric_and_colorectal_carcinomas -RSB- .
11124908	0	NPY	82,85	neuropeptide_Y	40,54	NPY	neuropeptide Y	4852	4852	Gene	Gene	comparison|nmod|START_ENTITY Structure|dep|comparison Structure|nmod|END_ENTITY	Structure and dynamics of micelle-bound neuropeptide_Y : comparison with unligated NPY and implications for receptor selection .
11458203	0	NPY	27,30	neuropeptide_Y	11,25	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- , galanin and vasoactive intestinal peptide -LRB- VIP -RRB- on pituitary hormone release and on ovarian steroidogenesis .
11606443	0	NPY	36,39	neuropeptide_Y	20,34	NPY	neuropeptide Y	4852	4852	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Novel expression of neuropeptide_Y -LRB- NPY -RRB- mRNA in hypothalamic regions during development : region-specific effects of maternal deprivation on NPY and Agouti-related_protein mRNA .
12005258	0	NPY	37,40	neuropeptide_Y	21,35	NPY	neuropeptide Y	4852	4852	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of hypothalamic neuropeptide_Y -LRB- NPY -RRB- in the change of feeding behavior induced by repeated treatment of amphetamine .
15897713	0	NPY	62,65	neuropeptide_Y	46,60	NPY	neuropeptide Y	4852	4852	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel single nucleotide polymorphism of the neuropeptide_Y -LRB- NPY -RRB- gene associated with alcohol_dependence .
15926114	0	NPY	44,47	neuropeptide_Y	28,42	NPY	neuropeptide Y	4852	4852	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Leu7Pro polymorphism in the neuropeptide_Y -LRB- NPY -RRB- gene is associated with impaired_glucose_tolerance and type 2 diabetes in Swedish men .
16160600	0	NPY	40,43	neuropeptide_Y	24,38	NPY	neuropeptide Y	475257(Tax:9615)	475257(Tax:9615)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of endogenous neuropeptide_Y -LRB- NPY -RRB- on the sympathetic-parasympathetic interaction in the canine heart .
1635665	0	NPY	37,40	neuropeptide_Y	21,35	NPY	neuropeptide Y	504216(Tax:9913)	504216(Tax:9913)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of dopamine-beta-hydroxylase .
16380708	0	NPY	70,73	neuropeptide_Y	54,68	NPY	neuropeptide Y	4852	4852	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Sibutramine therapy in obese women -- effects on plasma neuropeptide_Y -LRB- NPY -RRB- , insulin , leptin and beta-endorphin concentrations .
1955194	0	NPY	63,66	neuropeptide_Y	47,61	NPY	neuropeptide Y	475257(Tax:9615)	475257(Tax:9615)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Clonidine but not propranolol decreases plasma neuropeptide_Y -LRB- NPY -RRB- levels .
20691708	0	NPY	66,69	neuropeptide_Y	50,64	NPY	neuropeptide Y	4852	4852	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Leu7Pro polymorphism of the signal peptide of neuropeptide_Y -LRB- NPY -RRB- gene is associated with increased levels of inflammatory markers preceding vascular_complications in patients with type 2 diabetes .
2113859	0	NPY	38,41	neuropeptide_Y	22,36	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Physiological role of neuropeptide_Y -LRB- NPY -RRB- in control of anterior pituitary hormone release in the rat .
21473895	0	NPY	45,48	neuropeptide_Y	29,43	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Intraperitoneal injection of neuropeptide_Y -LRB- NPY -RRB- alters neurotrophin rat hypothalamic levels : Implications for NPY potential role in stress-related disorders .
2188228	0	NPY	55,58	neuropeptide_Y	39,53	NPY	neuropeptide Y	4852	4852	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	An immunohistochemical localization of neuropeptide_Y -LRB- NPY -RRB- in its amidated form in human frontal cortex .
2388526	0	NPY	38,41	neuropeptide_Y	22,36	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of neuropeptide_Y -LRB- NPY -RRB- on CRF and stress-induced cecal motor response in rats .
23994577	0	NPY	87,90	neuropeptide_Y	71,85	NPY	neuropeptide Y	4852	4852	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide_Y -LRB- NPY -RRB- expression in the human SH-SY5Y neuroblastoma cell line .
25221996	0	NPY	31,34	neuropeptide_Y	15,29	NPY	neuropeptide Y	4852	4852	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of neuropeptide_Y -LRB- NPY -RRB- , interleukin-1B -LRB- IL1B -RRB- genetic variants and correlation of IL1B transcript levels with vitiligo susceptibility .
2747854	0	NPY	45,48	neuropeptide_Y	29,43	NPY	neuropeptide Y	100724008	100724008	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Bronchoconstrictor action of neuropeptide_Y -LRB- NPY -RRB- in isolated guinea_pig airways .
2852058	0	NPY	62,65	neuropeptide_Y	46,60	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Quantitative autoradiographic localization of neuropeptide_Y -LRB- NPY -RRB- binding sites in rat posterior pituitary lobe .
3018392	0	NPY	27,30	neuropeptide_Y	11,25	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- at the sympathetic neuroeffector junction .
3108675	0	NPY	27,30	neuropeptide_Y	11,25	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of neuropeptide_Y -LRB- NPY -RRB- induced by tyramine in the isolated vas deferens of rat .
3212674	0	NPY	24,27	neuropeptide_Y	8,22	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of neuropeptide_Y -LRB- NPY -RRB- in cardiovascular responses to stress .
3591369	0	NPY	27,30	neuropeptide_Y	11,25	NPY	neuropeptide Y	100724008	100724008	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- on isolated guinea-pig heart .
3754818	0	NPY	44,47	neuropeptide_Y	28,42	NPY	neuropeptide Y	100301542(Tax:9986)	100301542(Tax:9986)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Tyramine-induced release of neuropeptide_Y -LRB- NPY -RRB- in isolated rabbit intestine .
3839860	0	NPY	42,45	neuropeptide_Y	26,40	NPY	neuropeptide Y	475257(Tax:9615)	475257(Tax:9615)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Vasoconstrictor effect of neuropeptide_Y -LRB- NPY -RRB- on canine coronary artery .
3914636	0	NPY	27,30	neuropeptide_Y	11,25	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- on the release of anterior pituitary hormones in the rat .
6091417	0	NPY	27,30	neuropeptide_Y	11,25	NPY	neuropeptide Y	100724008	100724008	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- on mechanical activity and neurotransmission in the heart , vas deferens and urinary bladder of the guinea-pig .
6382043	0	NPY	71,74	neuropeptide_Y	55,69	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Electron microscope immunocytochemical localization of neuropeptide_Y -LRB- NPY -RRB- in the rat brain .
6386172	0	NPY	51,54	neuropeptide_Y	35,49	NPY	neuropeptide Y	4852	4852	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of neuropeptide_Y -LRB- NPY -RRB- in the human hypothalamus .
6548713	0	NPY	30,33	neuropeptide_Y	14,28	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of neuropeptide_Y -LRB- NPY -RRB- binding by guanine_nucleotides in the rat cerebral cortex .
7685440	0	NPY	48,51	neuropeptide_Y	32,46	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Depressor effect of intrathecal neuropeptide_Y -LRB- NPY -RRB- Is mediated by Y2 subtype of NPY receptors .
7707867	0	NPY	46,49	neuropeptide_Y	30,44	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Adrenal steroid regulation of neuropeptide_Y -LRB- NPY -RRB- mRNA : differences between dentate hilus and locus coeruleus and arcuate nucleus .
7909929	0	NPY	37,40	neuropeptide_Y	21,35	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of tyrosine_hydroxylase .
8564255	0	NPY	36,39	neuropeptide_Y	20,34	NPY	neuropeptide Y	4852	4852	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Characterization of neuropeptide_Y -LRB- NPY -RRB- receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226 .
8584757	0	NPY	77,80	neuropeptide_Y	61,75	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Central administration of antisense oligodeoxynucleotides to neuropeptide_Y -LRB- NPY -RRB- mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release .
8743297	0	NPY	45,48	neuropeptide_Y	29,43	NPY	neuropeptide Y	4852	4852	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Epitopic characterization of neuropeptide_Y -LRB- NPY -RRB- by alanine-scanning mutagenesis .
9013028	0	NPY	40,43	neuropeptide_Y	24,38	NPY	neuropeptide Y	4852	4852	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Transient expression of neuropeptide_Y -LRB- NPY -RRB- immunoreactivity in the developing hamster paraventricular thalamic area is due to apoptosis .
9802416	0	NPY	27,30	neuropeptide_Y	11,25	NPY	neuropeptide Y	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Suppressed neuropeptide_Y -LRB- NPY -RRB- mRNA in rat amygdala following restraint stress .
3351430	0	NPY	42,45	neuropeptide_tyrosine_Y	17,40	NPY	neuropeptide tyrosine Y	4852	4852	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of neuropeptide_tyrosine_Y -LRB- NPY -RRB- are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations .
21154196	0	NPY	43,46	oxytocin	9,17	NPY	oxytocin	4852	5020	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Systemic oxytocin administration modulates NPY response to insulin-induced hypoglycemia in man .
2875137	0	NPY	14,17	somatostatin	20,32	NPY	somatostatin	100724008	100730851	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Topography of NPY - , somatostatin - , and VIP-immunoreactive , neuronal subpopulations in the guinea_pig celiac-superior mesenteric ganglion and their projection to the pylorus .
15090072	0	NPY1R	207,212	NPY5R	214,219	NPY1R	NPY5R	4886	4889	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units -LRB- AMPA 2 , GLRA3 , GLRB -RRB- and neuropeptide receptors NPY1R , NPY5R .
22629465	0	NPY2R	26,31	Neuropeptide_Y2_receptor	0,24	NPY2R	Neuropeptide Y2 receptor	4887	4887	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Neuropeptide_Y2_receptor -LRB- NPY2R -RRB- expression in saliva predicts feeding immaturity in the premature_neonate .
17235527	0	NPY2R	65,70	neuropeptide_Y2_receptor	39,63	NPY2R	neuropeptide Y2 receptor	4887	4887	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms in the neuropeptide_Y2_receptor -LRB- NPY2R -RRB- gene and association with severe obesity in French white subjects .
17992642	0	NPY2R	69,74	neuropeptide_Y2_receptor	43,67	NPY2R	neuropeptide Y2 receptor	4887	4887	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association of sequence variants in the neuropeptide_Y2_receptor -LRB- NPY2R -RRB- gene with early onset obesity in Germans .
15090072	0	NPY5R	214,219	NPY1R	207,212	NPY5R	NPY1R	4889	4886	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units -LRB- AMPA 2 , GLRA3 , GLRB -RRB- and neuropeptide receptors NPY1R , NPY5R .
24326025	0	NQO-1	40,45	Protease-activated_receptor-2	0,29	NQO-1	Protease-activated receptor-2	1728	2150	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Protease-activated_receptor-2 activates NQO-1 via Nrf2 stabilization in keratinocytes .
18455424	0	NQO1	24,28	Akt	43,46	NQO1	Akt	24314(Tax:10116)	24185(Tax:10116)	Gene	Gene	START_ENTITY|dep|signaling signaling|compound|END_ENTITY	Bromocriptine activates NQO1 via Nrf2-PI3K / Akt signaling : novel cytoprotective mechanism against oxidative damage .
20373852	0	NQO1	90,94	CYP1A1	30,36	NQO1	CYP1A1	1728	1543	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|compound|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	NQO1	90,94	CYP2C19	46,53	NQO1	CYP2C19	1728	1557	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	NQO1	90,94	CYP2C9	38,44	NQO1	CYP2C9	1728	1559	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	NQO1	90,94	CYP2D6	55,61	NQO1	CYP2D6	1728	1565	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12460800	0	NQO1	53,57	CYP2E1	40,46	NQO1	CYP2E1	1728	1571	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association of genetic polymorphisms in CYP2E1 , MPO , NQO1 , GSTM1 , and GSTT1 genes with benzene_poisoning .
15670828	0	NQO1	26,30	DT-diaphorase	11,24	NQO1	DT-diaphorase	1728	1728	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	No role of DT-diaphorase -LRB- NQO1 -RRB- in the protection against oxidized quercetin .
9516435	0	NQO1	33,37	DT_diaphorase	18,31	NQO1	DT diaphorase	18104(Tax:10090)	18104(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Disruption of the DT_diaphorase -LRB- NQO1 -RRB- gene in mice leads to increased menadione toxicity .
22178546	0	NQO1	29,33	Dyrk1a	0,6	NQO1	Dyrk1a	18104(Tax:10090)	13548(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf 2 dependent mechanism .
18986377	0	NQO1	63,67	GSTM1	49,54	NQO1	GSTM1	1728	2944	Gene	Gene	PSTI|appos|START_ENTITY PSTI|compound|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20373852	0	NQO1	90,94	GSTM1	70,75	NQO1	GSTM1	1728	2944	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
16235982	0	NQO1	27,31	GSTT1	0,5	NQO1	GSTT1	1728	2952	Gene	Gene	polymorphism|compound|START_ENTITY deletions|appos|polymorphism deletions|compound|END_ENTITY	GSTT1 and GSTM1 deletions , NQO1 C609T polymorphism and risk of chronic_myelogenous_leukemia in Japanese .
18986377	0	NQO1	63,67	GSTT1	56,61	NQO1	GSTT1	1728	2952	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20373852	0	NQO1	90,94	GSTT1	63,68	NQO1	GSTT1	1728	2952	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
17545194	0	NQO1	80,84	INSR	68,72	NQO1	INSR	1728	3643	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Cross-species microarray analysis with the OSCAR system suggests an INSR - > Pax6 - > NQO1 neuro-protective pathway in aging and Alzheimer 's _ disease .
18986377	0	NQO1	63,67	LPL	75,78	NQO1	LPL	1728	4023	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
12460800	0	NQO1	53,57	MPO	48,51	NQO1	MPO	1728	4353	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association of genetic polymorphisms in CYP2E1 , MPO , NQO1 , GSTM1 , and GSTT1 genes with benzene_poisoning .
17424838	0	NQO1	31,35	MPO	26,29	NQO1	MPO	1728	4353	Gene	Gene	UGT1A6|appos|START_ENTITY UGT1A6|compound|END_ENTITY	-LSB- Genetic polymorphisms of MPO , NQO1 , GSTP1 , UGT1A6 associated with susceptibility of chronic benzene_poisoning -RSB- .
20373852	0	NQO1	90,94	MTHFR	77,82	NQO1	MTHFR	1728	4524	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
20373852	0	NQO1	90,94	MTRR	84,88	NQO1	MTRR	1728	4552	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
18997460	0	NQO1	72,76	NADPH-quinone_oxidoreductase	42,70	NQO1	NADPH-quinone oxidoreductase	24314(Tax:10116)	24314(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The natural compound ascorbigen modulates NADPH-quinone_oxidoreductase -LRB- NQO1 -RRB- mRNA and enzyme activity levels in cultured liver cells and in laboratory_rats .
18986377	0	NQO1	63,67	NAT2	69,73	NQO1	NAT2	1728	10	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
20373852	0	NQO1	90,94	NAT2	96,100	NQO1	NAT2	1728	10	Gene	Gene	HLA-DQA1|appos|START_ENTITY HLA-DQA1|appos|END_ENTITY	Microarray-based detection of CYP1A1 , CYP2C9 , CYP2C19 , CYP2D6 , GSTT1 , GSTM1 , MTHFR , MTRR , NQO1 , NAT2 , HLA-DQA1 , and AB0 allele frequencies in native Russians .
12960511	0	NQO1	90,94	NQO2	96,100	NQO1	NQO2	1728	4835	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Association analyses between polymorphisms of the phase II detoxification enzymes -LRB- GSTM1 , NQO1 , NQO2 -RRB- and alcohol_withdrawal_symptoms .
17462537	0	NQO1	41,45	Nrf2	10,14	NQO1	Nrf2	1728	4780	Gene	Gene	expression|compound|START_ENTITY Action|nmod|expression Action|nmod|END_ENTITY	Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin .
18813798	0	NQO1	71,75	Nrf2	80,84	NQO1	Nrf2	1728	4780	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic_acid in human leukemia HL-60 cells .
19452436	0	NQO1	48,52	Nrf2	160,164	NQO1	Nrf2	18104(Tax:10090)	18024(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY chinensis|nsubj|Induction chinensis|nmod|accumulation accumulation|nmod|END_ENTITY	Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2 .
22010800	0	NQO1	43,47	Nrf2	12,16	NQO1	Nrf2	1728	4780	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Dynamics of Nrf2 and Keap1 in ARE-mediated NQO1 expression by wasabi 6 - -LRB- methylsulfinyl -RRB- hexyl_isothiocyanate .
18986377	0	NQO1	63,67	PRSS1	80,85	NQO1	PRSS1	1728	5644	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
17545194	0	NQO1	80,84	Pax6	74,78	NQO1	Pax6	1728	5080	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Cross-species microarray analysis with the OSCAR system suggests an INSR - > Pax6 - > NQO1 neuro-protective pathway in aging and Alzheimer 's _ disease .
11867746	0	NQO1	0,4	p53	16,19	NQO1	p53	1728	7157	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	NQO1 stabilizes p53 through a distinct pathway .
12960511	0	NQO2	96,100	NQO1	90,94	NQO2	NQO1	4835	1728	Gene	Gene	GSTM1|dep|START_ENTITY GSTM1|dep|END_ENTITY	Association analyses between polymorphisms of the phase II detoxification enzymes -LRB- GSTM1 , NQO1 , NQO2 -RRB- and alcohol_withdrawal_symptoms .
7796170	0	NR-1	137,141	c-jun	38,43	NR-1	c-jun	2902	3725	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of the immediate early gene c-jun in human spinal cord in amyotrophic_lateral_sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA .
18716981	0	NR0B1	84,89	DAX-1	91,96	NR0B1	DAX-1	190	190	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Extreme hyponatremia in an infant with congenital_adrenal_hypoplasia due to a novel NR0B1 -LRB- DAX-1 -RRB- mutation .
21227944	0	NR0B1	119,124	DAX-1	112,117	NR0B1	DAX-1	190	190	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Birth after TESE-ICSI in a man with hypogonadotropic_hypogonadism and congenital_adrenal_hypoplasia linked to a DAX-1 -LRB- NR0B1 -RRB- mutation .
15841486	0	NR0B1	32,37	DAX1	39,43	NR0B1	DAX1	190	190	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Thirteen novel mutations in the NR0B1 -LRB- DAX1 -RRB- gene as cause of adrenal_hypoplasia_congenita .
16355812	0	NR0B1	38,43	DAX1	32,36	NR0B1	DAX1	190	190	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel deletion mutations of the DAX1 -LRB- NR0B1 -RRB- gene in two Taiwanese families with X-linked adrenal_hypoplasia_congenita .
16709599	0	NR0B1	111,116	DAX1	104,108	NR0B1	DAX1	190	190	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Dosage-sensitive sex reversal adrenal_hypoplasia_congenita critical region on the X chromosome , gene 1 -LRB- DAX1 -RRB- -LRB- NR0B1 -RRB- and small_heterodimer_partner -LRB- SHP -RRB- -LRB- NR0B2 -RRB- form homodimers individually , as well as DAX1-SHP heterodimers .
19773398	0	NR0B1	154,159	DAX1	161,165	NR0B1	DAX1	190	190	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	X-linked congenital adrenal_hypoplasia_with_hypogonadotropic_hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 -LRB- DAX1 -RRB- gene .
25079468	0	NR0B1	24,29	DAX1	31,35	NR0B1	DAX1	190	190	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the NR0B1 -LRB- DAX1 -RRB- gene in a large family with two boys affected by congenital_adrenal_hypoplasia .
22843091	0	NR0B1	30,35	PPARy	21,26	NR0B1	PPARy	190	5468	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of PPARy on NR0B1 in tumorigenesis of lung_adenocarcinoma .
24029697	0	NR1	15,18	NR2A	20,24	NR1	NR2A	2902	2903	Gene	Gene	START_ENTITY|appos|expression expression|nummod|END_ENTITY	Involvement of NR1 , NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring .
12391275	0	NR1	59,62	NR3A	15,19	NR1	NR3A	24408(Tax:10116)	191573(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits .
16289403	0	NR1	43,46	PI3-K	70,75	NR1	PI3-K	24408(Tax:10116)	298947(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Electroacupuncture regulates NMDA receptor NR1 subunit expression via PI3-K pathway in a rat model of cerebral_ischemia-reperfusion .
24311788	0	NR1D1	77,82	Apolipoprotein_A-IV	0,19	NR1D1	Apolipoprotein A-IV	217166(Tax:10090)	11808(Tax:10090)	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Apolipoprotein_A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1 .
18055760	0	NR1H3	204,209	RORalpha	173,181	NR1H3	RORalpha	22259(Tax:10090)	19883(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Identification of oxysterol_7alpha-hydroxylase -LRB- Cyp7b1 -RRB- as a novel retinoid-related_orphan_receptor_alpha -LRB- RORalpha -RRB- -LRB- NR1F1 -RRB- target gene and a functional cross-talk between RORalpha and liver X receptor -LRB- NR1H3 -RRB- .
21918980	0	NR1I2	67,72	ABCB1	46,51	NR1I2	ABCB1	8856	5243	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	A comprehensive study of polymorphisms in the ABCB1 , ABCC2 , ABCG2 , NR1I2 genes and lymphoma risk .
17925385	0	NR1I2	96,101	CYP3A4	129,135	NR1I2	CYP3A4	8856	1576	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane_X_receptor / NR1I2 and their association with CYP3A4 expression .
20959500	0	NR1I2	65,70	CYP3A4	13,19	NR1I2	CYP3A4	8856	1576	Gene	Gene	Role|nmod|START_ENTITY Induction|dep|Role Induction|nmod|END_ENTITY	Induction of CYP3A4 by vinblastine : Role of the nuclear receptor NR1I2 .
15618712	0	NR1I2	52,57	PXR	59,62	NR1I2	PXR	8856	8856	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Eleven novel single nucleotide polymorphisms in the NR1I2 -LRB- PXR -RRB- gene , four of which induce non-synonymous amino_acid alterations .
18381611	0	NR1I2	68,73	pregnane-X_receptor	42,61	NR1I2	pregnane-X receptor	8856	8856	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation of associations between the pregnane-X_receptor gene -LRB- NR1I2 -RRB- and Crohn 's _ disease in Canadian children using a gene-wide haplotype-based approach .
18220558	0	NR1I2	48,53	pregnane_X_receptor	27,46	NR1I2	pregnane X receptor	8856	8856	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A pharmacogenetic study of pregnane_X_receptor -LRB- NR1I2 -RRB- in Han Chinese .
26141049	0	NR1I2	8,13	pregnane_X_receptor	15,34	NR1I2	pregnane X receptor	8856	8856	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of NR1I2 -LRB- pregnane_X_receptor -RRB- polymorphisms in head_and_neck_squamous_cell_carcinoma .
12103442	0	NR2A	45,49	GluR_epsilon_1	29,43	NR2A	GluR epsilon 1	14811(Tax:10090)	14811(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Early onset of NMDA receptor GluR_epsilon_1 -LRB- NR2A -RRB- expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus .
21653857	0	NR2A	17,21	IQGAP1	0,6	NR2A	IQGAP1	14811(Tax:10090)	29875(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	IQGAP1 regulates NR2A signaling , spine density , and cognitive processes .
24029697	0	NR2A	20,24	NR1	15,18	NR2A	NR1	2903	2902	Gene	Gene	expression|nummod|START_ENTITY END_ENTITY|appos|expression	Involvement of NR1 , NR2A different expression in brain regions in anxiety-like behavior of prenatally stressed offspring .
17622578	0	NR2A	37,41	NR2B	44,48	NR2A	NR2B	2903	2904	Gene	Gene	agonist|nmod|START_ENTITY agonist|dep|END_ENTITY	Subunit-specific agonist activity at NR2A - , NR2B - , NR2C - , and NR2D-containing N-methyl-D-aspartate_glutamate receptors .
20107120	0	NR2A	45,49	RasGRF1	110,117	NR2A	RasGRF1	2903	5923	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1 .
10381539	0	NR2B	124,128	Brain-derived_neurotrophic_factor	0,33	NR2B	Brain-derived neurotrophic factor	24410(Tax:10116)	24225(Tax:10116)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density .
25276438	0	NR2B	58,62	CA1	50,53	NR2B	CA1	14812(Tax:10090)	12346(Tax:10090)	Gene	Gene	Receptors|compound|START_ENTITY END_ENTITY|nmod|Receptors	Abeta -LRB- 1-42 -RRB- Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors .
18184784	0	NR2B	52,56	Cdk5	0,4	NR2B	Cdk5	2904	1020	Gene	Gene	tyrosine|dep|START_ENTITY receptors|amod|tyrosine phosphorylation|nmod|receptors regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors .
24607229	0	NR2B	51,55	Cdk5	32,36	NR2B	Cdk5	2904	1020	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Memory enhancement by targeting Cdk5 regulation of NR2B .
18694808	0	NR2B	45,49	EphrinB2	0,8	NR2B	EphrinB2	24410(Tax:10116)	306636(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia .
21147838	0	NR2B	105,109	EphrinB2	0,8	NR2B	EphrinB2	24410(Tax:10116)	306636(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY potentiation|nmod|phosphorylation induces|dobj|potentiation induces|nsubj|END_ENTITY	EphrinB2 induces pelvic-urethra reflex potentiation via Src kinase-dependent tyrosine phosphorylation of NR2B .
25565773	0	NR2B	101,105	Fyn	92,95	NR2B	Fyn	24410(Tax:10116)	25150(Tax:10116)	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Postsynaptic_density_protein_95-regulated NR2B tyrosine phosphorylation and interactions of Fyn with NR2B in levodopa-induced_dyskinesia rat models .
25364551	0	NR2B	64,68	Growth_Hormone	37,51	NR2B	Growth Hormone	24410(Tax:10116)	81668(Tax:10116)	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	Co-Application of Corticosterone and Growth_Hormone Upregulates NR2B Protein and Increases the NR2B : NR2A Ratio and Synaptic Transmission in the Hippocampus .
17622578	0	NR2B	44,48	NR2A	37,41	NR2B	NR2A	2904	2903	Gene	Gene	agonist|dep|START_ENTITY agonist|nmod|END_ENTITY	Subunit-specific agonist activity at NR2A - , NR2B - , NR2C - , and NR2D-containing N-methyl-D-aspartate_glutamate receptors .
19864302	0	NR2B	122,126	ephrinB2	11,19	NR2B	ephrinB2	2904	1948	Gene	Gene	phosphorylation|nmod|START_ENTITY sensitization|nmod|phosphorylation mediates|dobj|sensitization mediates|nsubj|END_ENTITY	Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B .
10336677	0	NR2C	47,51	Sp1	64,67	NR2C	Sp1	14813(Tax:10090)	20683(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the murine NMDA-receptor-subunit NR2C promoter by Sp1 and fushi_tarazu_factor1 -LRB- FTZ-F1 -RRB- homologues .
19823680	0	NR2E3	39,44	CRX	94,97	NR2E3	CRX	10002	1406	Gene	Gene	domain|nmod|START_ENTITY Mutations|nmod|domain affect|nsubj|Mutations affect|nmod|END_ENTITY	Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX .
22174013	0	NR2E3	56,61	ESR1	95,99	NR2E3	ESR1	10002	2099	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast_cancer .
26800338	0	NR2F2	55,60	MiR-382	0,7	NR2F2	MiR-382	7026	494331	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-382 inhibits cell growth and invasion by targeting NR2F2 in colorectal_cancer .
24899578	0	NR2F2	21,26	star	37,41	NR2F2	star	11819(Tax:10090)	20845(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	The nuclear receptor NR2F2 activates star expression and steroidogenesis in mouse MA-10 and MLTC-1 Leydig cells .
20304030	0	NR3A	41,45	MAP1B	0,5	NR3A	MAP1B	242443(Tax:10090)	17755(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	MAP1B binds to the NMDA receptor subunit NR3A and affects NR3A protein concentrations .
25652449	0	NR3A	60,64	NMDA_receptor_subunit_GluN3A	30,58	NR3A	NMDA receptor subunit GluN3A	242443(Tax:10090)	242443(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A neuroprotective role of the NMDA_receptor_subunit_GluN3A -LRB- NR3A -RRB- in ischemic_stroke of the adult mouse .
12391275	0	NR3A	15,19	NR1	59,62	NR3A	NR1	191573(Tax:10116)	24408(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of NR3A with the N-methyl-D-aspartate receptor NR1 and NR2 subunits .
21135540	0	NR3A	68,72	Rheb	32,36	NR3A	Rheb	242443(Tax:10090)	19744(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the small GTPase Rheb with the NMDA receptor subunit NR3A .
17658481	0	NR3A	18,22	microtubule-associated_protein_1S	38,71	NR3A	microtubule-associated protein 1S	191573(Tax:10116)	290640(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The NMDAR subunit NR3A interacts with microtubule-associated_protein_1S in the brain .
17765677	0	NR3B2	31,36	Estrogen-related_receptor_beta	0,30	NR3B2	Estrogen-related receptor beta	2103	2103	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	Estrogen-related_receptor_beta / NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis .
24713862	0	NR3C1	30,35	Glucocorticoid_receptor	0,23	NR3C1	Glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glucocorticoid_receptor gene -LRB- NR3C1 -RRB- methylation following stressful events between birth and adolescence .
26073068	0	NR3C1	30,35	Glucocorticoid_receptor	0,23	NR3C1	Glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glucocorticoid_receptor gene -LRB- NR3C1 -RRB- methylation processes as mediators of early adversity in stress-related disorders causality : A critical review .
26782558	0	NR3C1	30,35	Glucocorticoid_receptor	0,23	NR3C1	Glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glucocorticoid_receptor gene -LRB- NR3C1 -RRB- promoter is hypermethylated in Thai females with major depressive_disorder .
12754700	0	NR3C1	54,59	glucocorticoid_receptor	24,47	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variations of the human glucocorticoid_receptor gene -LRB- NR3C1 -RRB- : pathological and in vitro mutations and polymorphisms .
15770078	0	NR3C1	35,40	glucocorticoid_receptor	42,65	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel genetic polymorphisms in the NR3C1 -LRB- glucocorticoid_receptor -RRB- gene in a Japanese population .
16216909	0	NR3C1	42,47	glucocorticoid_receptor	17,40	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the glucocorticoid_receptor -LRB- NR3C1 -RRB- gene 5 ' untranslated region : identification , and tissue distribution of multiple new human exon 1 .
16676134	0	NR3C1	54,59	glucocorticoid_receptor	24,47	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variants in the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- and cardiovascular_disease risk .
18536531	0	NR3C1	102,107	glucocorticoid_receptor	72,95	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prenatal exposure to maternal depression , neonatal methylation of human glucocorticoid_receptor gene -LRB- NR3C1 -RRB- and infant cortisol stress responses .
19133980	0	NR3C1	144,149	glucocorticoid_receptor	114,137	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Glucocorticoid_resistance in a multiple myeloma cell line is regulated by a transcription elongation block in the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- .
19933394	0	NR3C1	202,207	glucocorticoid_receptor	172,195	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Neonatal complete generalized glucocorticoid resistance and growth_hormone_deficiency caused by a novel homozygous mutation in Helix 12 of the ligand binding domain of the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- .
22714792	0	NR3C1	65,70	glucocorticoid_receptor	40,63	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic and epigenetic variation of the glucocorticoid_receptor -LRB- NR3C1 -RRB- in placenta and infant_neurobehavior .
22832351	0	NR3C1	55,60	glucocorticoid_receptor	25,48	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Increased methylation of glucocorticoid_receptor gene -LRB- NR3C1 -RRB- in adults with a history of childhood maltreatment : a link with the severity and type of trauma .
23566423	0	NR3C1	153,158	glucocorticoid_receptor	123,146	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- promoter region in cord blood .
27000245	0	NR3C1	58,63	glucocorticoid_receptor	33,56	NR3C1	glucocorticoid receptor	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequencing analysis of the human glucocorticoid_receptor -LRB- NR3C1 -RRB- gene in multiple_sclerosis patients .
16237153	0	NR4A1	28,33	insulin-like_3	44,58	NR4A1	insulin-like 3	15370(Tax:10090)	16336(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	The orphan nuclear receptor NR4A1 regulates insulin-like_3 gene transcription in Leydig cells .
24086717	0	NR4A2	0,5	gastrin	22,29	NR4A2	gastrin	4929	2520	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	NR4A2 is regulated by gastrin and influences cellular responses of gastric_adenocarcinoma cells .
22474171	0	NR5A1	105,110	SF-1	112,116	NR5A1	SF-1	2516	7536	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Testosterone production during puberty in two 46 , XY patients with disorders_of_sex_development and novel NR5A1 -LRB- SF-1 -RRB- mutations .
23543655	0	NR5A1	0,5	SF-1	7,11	NR5A1	SF-1	2516	7536	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	NR5A1 -LRB- SF-1 -RRB- mutations are not a major cause of primary ovarian_insufficiency .
21242195	0	NR5A1	47,52	SF1	42,45	NR5A1	SF1	2516	7536	Gene	Gene	changes|appos|START_ENTITY changes|compound|END_ENTITY	Identification of novel SRY mutations and SF1 -LRB- NR5A1 -RRB- changes in patients with pure gonadal_dysgenesis and 46 , XY karyotype .
21654157	0	NR5A1	24,29	SF1	31,34	NR5A1	SF1	2516	7536	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Partial deletion of the NR5A1 -LRB- SF1 -RRB- gene detected by synthetic probe MLPA in a patient with XY_gonadal_disorder of sex development .
23219870	0	NR5A1	46,51	steroidogenic_factor-1	22,44	NR5A1	steroidogenic factor-1	2516	2516	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Distinct functions of steroidogenic_factor-1 -LRB- NR5A1 -RRB- in the nucleus and the centrosome .
24632207	0	NR5A2	31,36	Glut4	47,52	NR5A2	Glut4	26424(Tax:10090)	20528(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY increases|nsubj|Activation increases|dobj|expression expression|amod|END_ENTITY	Activation of nuclear receptor NR5A2 increases Glut4 expression and glucose metabolism in muscle cells .
24737860	0	NR5A2	23,28	LRH-1	17,22	NR5A2	LRH-1	26424(Tax:10090)	26424(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	Nuclear receptor LRH-1 / NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution .
23536856	0	NR5A2	0,5	Lhb	16,19	NR5A2	Lhb	26424(Tax:10090)	16866(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro , but is dispensable for gonadotropin synthesis and fertility in vivo .
24567339	0	NRA-2	0,5	nicalin	9,16	NRA-2	nicalin	172803(Tax:6239)	172803(Tax:6239)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	NRA-2 , a nicalin homolog , regulates neuronal_death by controlling surface localization of toxic Caenorhabditis_elegans DEG/ENaC channels .
16107717	0	NRAGE	0,5	p38	15,18	NRAGE	p38	9500	1432	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	NRAGE mediates p38 activation and neural progenitor apoptosis via the bone morphogenetic protein signaling cascade .
10985348	0	NRAGE	0,5	p75_neurotrophin_receptor	48,73	NRAGE	p75 neurotrophin receptor	9500	4804	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	NRAGE , a novel MAGE protein , interacts with the p75_neurotrophin_receptor and facilitates nerve growth factor-dependent apoptosis .
25083114	0	NRAMP1	94,100	Natural_Resistance-associated_Macrophage_Protein_1	28,78	NRAMP1	Natural Resistance-associated Macrophage Protein 1	100737298	100737298	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Polymorphism , Expression of Natural_Resistance-associated_Macrophage_Protein_1 Encoding Gene -LRB- NRAMP1 -RRB- and Its Association with Immune Traits in Pigs .
12358853	0	NRAMP1	24,30	SLC11A1	32,39	NRAMP1	SLC11A1	100033912(Tax:9796)	100033912(Tax:9796)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the NRAMP1 -LRB- SLC11A1 -RRB- gene in the horse -LRB- Equus_caballus L. -RRB- .
12552460	0	NRAMP1	34,40	SLC11A1	16,23	NRAMP1	SLC11A1	6556	6556	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism of SLC11A1 -LRB- formerly NRAMP1 -RRB- gene confers susceptibility to Kawasaki_disease .
18998137	0	NRAMP1	64,70	SLC11A1	72,79	NRAMP1	SLC11A1	6556	6556	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Genetic susceptibility to Beh __ et 's _ syndrome is associated with NRAMP1 -LRB- SLC11A1 -RRB- polymorphism in Turkish patients .
15825023	0	NRAMP1	73,79	natural_resistance-associated_macrophage_protein_1	16,66	NRAMP1	natural resistance-associated macrophage protein 1	6556	6556	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of the natural_resistance-associated_macrophage_protein_1 gene -LRB- NRAMP1 -RRB- are associated with severe forms of pulmonary_tuberculosis .
9251591	0	NRAMP1	121,127	natural_resistance-associated_macrophage_protein_1	69,119	NRAMP1	natural resistance-associated macrophage protein 1	6556	6556	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No evidence for linkage between leprosy susceptibility and the human natural_resistance-associated_macrophage_protein_1 -LRB- NRAMP1 -RRB- gene in French Polynesia .
9699275	0	NRAMP1	67,73	natural_resistance-associated_macrophage_protein_1	15,65	NRAMP1	natural resistance-associated macrophage protein 1	100737298	100737298	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the natural_resistance-associated_macrophage_protein_1 -LRB- NRAMP1 -RRB- gene to pig chromosome 15 .
23153525	0	NRAS	20,24	BCL-2	25,30	NRAS	BCL-2	4893	596	Gene	Gene	START_ENTITY|amod|complex complex|amod|END_ENTITY	Localization of the NRAS : BCL-2 complex determines anti-apoptotic features associated with progressive_disease in myelodysplastic_syndromes .
16888631	0	NRAS	46,50	BRAF	68,72	NRAS	BRAF	4893	673	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|mutations mutations|compound|END_ENTITY	Congenital melanocytic_nevi frequently harbor NRAS mutations but no BRAF mutations .
18679422	6	NRAS	1170,1174	BRAF	1061,1065	BRAF	NRAS	673	4893	Gene	Gene	inhibition|dep|START_ENTITY p16|advcl|inhibition p16|parataxis|suppressed suppressed|nmod|inhibition inhibition|nmod|END_ENTITY	These senescence phenotypes were p16 -LRB- INK4A -RRB- - or p53-independent , however , several of them were suppressed by genetic or pharmacological inhibition of BRAF -LRB- V600E -RRB- or phosphoinositide 3-kinase pathways , including rapamycin-mediated inhibition of mTOR-raptor in NRAS -LRB- Q61R -RRB- - expressing melanoma cells .
19492075	0	NRAS	99,103	BRAF	22,26	NRAS	BRAF	18176(Tax:10090)	109880(Tax:10090)	Gene	Gene	tumors|compound|START_ENTITY efficacy|nmod|tumors required|nmod|efficacy required|nsubjpass|Combined Combined|nmod|END_ENTITY	Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors .
20012784	0	NRAS	17,21	BRAF	11,15	NRAS	BRAF	4893	673	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
22389471	0	NRAS	138,142	BRAF	16,20	NRAS	BRAF	4893	673	Gene	Gene	mutations|compound|START_ENTITY mediated|nmod|mutations dabrafenib|acl|mediated overcome|nmod|dabrafenib inhibitors|xcomp|overcome inhibitors|nsubj|Combinations Combinations|nmod|END_ENTITY	Combinations of BRAF , MEK , and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib , mediated by NRAS or MEK mutations .
22389471	0	NRAS	138,142	BRAF	88,92	NRAS	BRAF	4893	673	Gene	Gene	mutations|compound|START_ENTITY mediated|nmod|mutations dabrafenib|acl|mediated dabrafenib|compound|END_ENTITY	Combinations of BRAF , MEK , and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib , mediated by NRAS or MEK mutations .
23666916	0	NRAS	96,100	BRAF	108,112	NRAS	BRAF	4893	673	Gene	Gene	KRAS|dep|START_ENTITY KRAS|dep|END_ENTITY	FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type -LRB- KRAS , NRAS , HRAS , BRAF -RRB- metastatic colorectal_cancer patients : a phase II trial by the Gruppo Oncologico Nord Ovest -LRB- GONO -RRB- .
25063807	0	NRAS	69,73	BRAF	132,136	NRAS	BRAF	4893	673	Gene	Gene	START_ENTITY|ccomp|acquired acquired|nmod|cells cells|compound|END_ENTITY	Mitogen-activated protein kinase -LRB- MAPK -RRB- hyperactivation and enhanced NRAS expression drive acquired vemurafenib resistance in V600E BRAF melanoma cells .
25343173	0	NRAS	120,124	BRAF	137,141	NRAS	BRAF	4893	673	Gene	Gene	Mutation|compound|START_ENTITY Mutation|nmod|Exons Exons|compound|END_ENTITY	Increased Levels of b-catenin , LEF-1 , and HPA-1 Correlate with Poor Prognosis for Acral_Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2 .
26004768	4	NRAS	1088,1092	BRAF	1082,1086	BRAF	NRAS	673	4893	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26134498	0	NRAS	83,87	BRAF	70,74	NRAS	BRAF	4893	673	Gene	Gene	mutant|compound|START_ENTITY activity|appos|mutant activity|nmod|SCH722984 SCH722984|nmod|mutant mutant|compound|END_ENTITY	Erratum to : Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant , NRAS mutant and wild-type melanoma .
26204954	0	NRAS	0,4	BRAF	14,18	NRAS	BRAF	4893	673	Gene	Gene	START_ENTITY|appos|immunohistochemistry immunohistochemistry|amod|END_ENTITY	NRAS -LRB- Q61R -RRB- , BRAF -LRB- V600E -RRB- immunohistochemistry : a concomitant tool for mutation screening in melanomas .
26204954	0	NRAS	0,4	BRAF	14,18	NRAS	BRAF	4893	673	Gene	Gene	START_ENTITY|appos|immunohistochemistry immunohistochemistry|amod|END_ENTITY	NRAS -LRB- Q61R -RRB- , BRAF -LRB- V600E -RRB- immunohistochemistry : a concomitant tool for mutation screening in melanomas .
26325103	0	NRAS	6,10	BRAF	12,16	NRAS	BRAF	4893	673	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|comparison comparison|amod|END_ENTITY	KRAS , NRAS , BRAF mutation comparison of endoscopic and surgically removed primary CRC paired samples : is endoscopy biopsy material adequate for molecular evaluation ?
26352110	0	NRAS	6,10	BRAF	12,16	NRAS	BRAF	4893	673	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	KRAS , NRAS , BRAF mutations and high counts of poorly_differentiated_clusters of neoplastic cells in colorectal_cancer : observational analysis of 175 cases .
23490205	0	NRAS	76,80	ERK1/2	32,38	NRAS	ERK1/2	4893	5595;5594	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS , vemurafenib-resistant melanoma cells .
20012784	0	NRAS	17,21	HRAS	29,33	NRAS	HRAS	4893	3265	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
23666916	0	NRAS	96,100	HRAS	102,106	NRAS	HRAS	4893	3265	Gene	Gene	KRAS|dep|START_ENTITY KRAS|dep|BRAF BRAF|compound|END_ENTITY	FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type -LRB- KRAS , NRAS , HRAS , BRAF -RRB- metastatic colorectal_cancer patients : a phase II trial by the Gruppo Oncologico Nord Ovest -LRB- GONO -RRB- .
20012784	0	NRAS	17,21	KRAS	23,27	NRAS	KRAS	4893	3845	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Absence of BRAF , NRAS , KRAS , HRAS mutations , and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto_thyroiditis from papillary_thyroid_carcinomas .
23585181	0	NRAS	21,25	KRAS	27,31	NRAS	KRAS	4893	3845	Gene	Gene	Application|nmod|START_ENTITY END_ENTITY|nsubj|Application	Application of BRAF , NRAS , KRAS mutations as markers for the detection of papillary thyroid_cancer from FNAB specimens by pyrosequencing analysis .
25132659	0	NRAS	68,72	KRAS	21,25	NRAS	KRAS	4893	3845	Gene	Gene	mutations|compound|START_ENTITY nodules|nmod|mutations different|nmod|nodules different|nsubj|nodules nodules|nmod|mutations mutations|compound|END_ENTITY	Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics .
26004768	4	NRAS	1088,1092	KRAS	1076,1080	BRAF	KRAS	673	3845	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26352110	0	NRAS	6,10	KRAS	0,4	NRAS	KRAS	4893	3845	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	KRAS , NRAS , BRAF mutations and high counts of poorly_differentiated_clusters of neoplastic cells in colorectal_cancer : observational analysis of 175 cases .
21704278	0	NRAS	6,10	PIK3CA	12,18	NRAS	PIK3CA	4893	5290	Gene	Gene	exon|compound|START_ENTITY exon|dep|END_ENTITY	KRAS , NRAS , PIK3CA exon 20 , and BRAF genotypes in synchronous and metachronous primary colorectal_cancers diagnostic and therapeutic implications .
26004768	4	NRAS	1088,1092	PIK3CA	1094,1100	BRAF	PIK3CA	673	5290	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
11956649	0	NRBP	42,46	Rac3	32,36	NRBP	Rac3	29959	5881	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the small GTPase Rac3 with NRBP , a protein with a kinase-homology domain .
18664314	0	NRCAM	52,57	neuronal_cell_adhesion_molecule	19,50	NRCAM	neuronal cell adhesion molecule	4897	4897	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the neuronal_cell_adhesion_molecule -LRB- NRCAM -RRB- gene variants with autism .
24168165	0	NRD1	0,4	MMP2	102,106	NRD1	MMP2	4898	4313	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	NRD1 , which encodes nardilysin protein , promotes esophageal_cancer cell invasion through induction of MMP2 and MMP3 expression .
10562553	0	NRF	59,62	NF-kappaB	117,126	NRF	NF-kappaB	55922	4790	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Constitutive silencing of IFN-beta promoter is mediated by NRF -LRB- NF-kappaB-repressing_factor -RRB- , a nuclear inhibitor of NF-kappaB .
23939472	0	NRF-1	56,61	FAM134C	12,19	NRF-1	FAM134C	4899	162427	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Novel genes FAM134C , C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons .
25431258	0	NRF-2	102,107	HO-1	108,112	NRF-2	HO-1	4780	3162	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Glucose-regulated_protein_78 -LRB- GRP78 -RRB- regulates colon_cancer metastasis through EMT biomarkers and the NRF-2 / HO-1 pathway .
24500986	0	NRF2	51,55	CYP2E1	0,6	NRF2	CYP2E1	83619(Tax:10116)	25086(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	CYP2E1 impairs GLUT4 gene expression and function : NRF2 as a possible mediator .
24500986	0	NRF2	51,55	GLUT4	15,20	NRF2	GLUT4	83619(Tax:10116)	25139(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	CYP2E1 impairs GLUT4 gene expression and function : NRF2 as a possible mediator .
23253326	0	NRF2	0,4	HO-1	68,72	NRF2	HO-1	4780	3162	Gene	Gene	activation|compound|START_ENTITY involved|nsubjpass|activation involved|nmod|upregulation upregulation|nmod|END_ENTITY	NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells .
17942419	0	NRF2	30,34	Heme_oxygenase-1	0,16	NRF2	Heme oxygenase-1	4780	3162	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Heme_oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1 .
20061377	0	NRF2	14,18	KEAP1	59,64	NRF2	KEAP1	4780	9817	Gene	Gene	Activation|nmod|START_ENTITY involves|nsubj|Activation involves|dobj|formation formation|nummod|END_ENTITY	Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation .
21357422	0	NRF2	41,45	KEAP1	51,56	NRF2	KEAP1	4780	9817	Gene	Gene	activate|dobj|START_ENTITY activate|nmod|mechanism mechanism|compound|END_ENTITY	Electrophilic nitro-fatty_acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism .
22215675	0	NRF2	63,67	KEAP1	107,112	NRF2	KEAP1	4780	9817	Gene	Gene	protein|compound|START_ENTITY degradation|nmod|protein inhibits|dobj|degradation inhibits|nmod|competitive competitive|nmod|protein protein|compound|END_ENTITY	Wilms_tumor gene on X chromosome -LRB- WTX -RRB- inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein .
22331464	0	NRF2	38,42	KEAP1	21,26	NRF2	KEAP1	4780	9817	Gene	Gene	accumulation|amod|START_ENTITY promote|dobj|accumulation interacts|xcomp|promote interacts|nmod|END_ENTITY	PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function .
23382044	0	NRF2	86,90	KEAP1	39,44	NRF2	KEAP1	4780	9817	Gene	Gene	ubiquitination|compound|START_ENTITY inhibit|dobj|ubiquitination proteins|acl:relcl|inhibit reveals|dobj|proteins reveals|nsubj|analysis analysis|nmod|END_ENTITY	Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination .
24322982	0	NRF2	41,45	KEAP1	28,33	NRF2	KEAP1	4780	9817	Gene	Gene	degradation|compound|START_ENTITY impair|dobj|degradation impair|nsubj|mutations mutations|nmod|END_ENTITY	Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination .
25793262	0	NRF2	80,84	KEAP1	73,78	NRF2	KEAP1	4780	9817	Gene	Gene	Activation|appos|START_ENTITY Activation|compound|END_ENTITY	Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1 , NRF2 Activation , and Glutathione Depletion In Vitro .
26301506	0	NRF2	76,80	KEAP1	84,89	NRF2	KEAP1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Affected|nmod|Activation Affected|nmod|Deletion Deletion|compound|END_ENTITY	Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid , RTA_405 .
23492819	0	NRF2	22,26	MicroRNA-93	0,11	NRF2	MicroRNA-93	4780	407051	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-93 regulates NRF2 expression and is associated with breast_carcinogenesis .
15790560	0	NRF2	56,60	NF-E2_p45-related_factor	30,54	NRF2	NF-E2 p45-related factor	18024(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of NF-E2_p45-related_factor -LRB- NRF2 -RRB- expression by the aryl_hydrocarbon_receptor-xenobiotic response element signaling pathway : direct cross-talk between phase I and II drug-metabolizing enzymes .
8943040	0	NRF2	0,4	NFE2	22,26	NRF2	NFE2	18024(Tax:10090)	18022(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	NRF2 , a member of the NFE2 family of transcription factors , is not essential for murine erythropoiesis , growth , and development .
22614957	0	NRF2	10,14	NFE2L2	21,27	NRF2	NFE2L2	4780	4780	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Increased NRF2 gene -LRB- NFE2L2 -RRB- copy number correlates with mutations in lung_squamous_cell_carcinomas .
25977470	0	NRF2	73,77	Nuclear_Factor-Erythroid_2-Related_Factor_2	28,71	NRF2	Nuclear Factor-Erythroid 2-Related Factor 2	4780	4780	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Hydrogen_Sulfide Levels and Nuclear_Factor-Erythroid_2-Related_Factor_2 -LRB- NRF2 -RRB- Activity Are Attenuated in the Setting of Critical_Limb_Ischemia -LRB- CLI -RRB- .
23697596	0	NRF2	47,51	OGG1	38,42	NRF2	OGG1	83619(Tax:10116)	81528(Tax:10116)	Gene	Gene	induction|compound|START_ENTITY END_ENTITY|nmod|induction	Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast_cancer .
26555609	0	NRF2	0,4	PINK1	15,20	NRF2	PINK1	4780	65018	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions .
22481913	0	NRF2	46,50	PPARy	0,5	NRF2	PPARy	4780	5468	Gene	Gene	Con|dep|START_ENTITY Stress|dep|Con Stress|compound|END_ENTITY	PPARy and Oxidative Stress : Con -LRB- b -RRB- Catenating NRF2 and FOXO .
21141598	0	NRF2	10,14	gamma-glutamylcysteine_synthetase	26,59	NRF2	gamma-glutamylcysteine synthetase	83619(Tax:10116)	25283(Tax:10116)	Gene	Gene	Roles|nmod|START_ENTITY Roles|acl|regulating regulating|advmod|END_ENTITY	-LSB- Roles of NRF2 regulating gamma-glutamylcysteine_synthetase in lung of rats with chronic_obstructive_pulmonary_disease -RSB- .
23697945	0	NRF2	117,121	thioredoxin_reductase_1	14,37	NRF2	thioredoxin reductase 1	18024(Tax:10090)	50493(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY protects|nmod|activity protects|nsubj|Disruption Disruption|nmod|END_ENTITY	Disruption of thioredoxin_reductase_1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity .
25827424	0	NRF2	64,68	xCT	14,17	NRF2	xCT	4780	23657	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of xCT and activity of system xc -LRB- - -RRB- are regulated by NRF2 in human breast_cancer cells in response to oxidative stress .
22378872	0	NRG-1	22,27	ErbB4	28,33	NRG-1	ErbB4	211323(Tax:10090)	13869(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The importance of the NRG-1 / ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric_disorders .
24152577	0	NRG-1	25,30	neuregulin-1	11,23	NRG-1	neuregulin-1	112400(Tax:10116)	112400(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Changes of neuregulin-1 -LRB- NRG-1 -RRB- expression in a rat model of overactive_bladder induced by partial urethral_obstruction : is NRG-1 a new biomarker of overactive_bladder ?
19458253	0	NRG1	16,20	Erbin	0,5	NRG1	Erbin	211323(Tax:10090)	59079(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	Erbin regulates NRG1 signaling and myelination .
18255317	0	NRG1	36,40	neuregulin-1	22,34	NRG1	neuregulin-1	3084	3084	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Association of 5 ' end neuregulin-1 -LRB- NRG1 -RRB- gene variation with subcortical medial frontal microstructure in humans .
16687441	0	NRG1	69,73	neuregulin_1	55,67	NRG1	neuregulin 1	3084	3084	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Meta-analysis shows strong positive association of the neuregulin_1 -LRB- NRG1 -RRB- gene with schizophrenia .
10369162	0	NRG2	24,28	neuregulin-2	10,22	NRG2	neuregulin-2	9542	9542	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human neuregulin-2 -LRB- NRG2 -RRB- gene : cloning , mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth_disease linked to 5q .
10618501	0	NRGN	106,110	neurogranin	93,104	NRGN	neurogranin	4900	4900	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a cis-acting element that interferes with thyroid hormone induction of the neurogranin -LRB- NRGN -RRB- gene .
21538840	0	NRGN	25,29	neurogranin	12,23	NRGN	neurogranin	4900	4900	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of neurogranin -LRB- NRGN -RRB- in schizophrenia .
9143500	0	NRGN	80,84	neurogranin	62,73	NRGN	neurogranin	4900	4900	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure , organization , and chromosomal mapping of the human neurogranin gene -LRB- NRGN -RRB- .
15254226	0	NRIF3	47,52	Metastasis-associated_protein_1	0,31	NRIF3	Metastasis-associated protein 1	23421	9112	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Metastasis-associated_protein_1 interacts with NRIF3 , an estrogen-inducible nuclear receptor coregulator .
12566383	0	NRL	49,52	Fiz1	118,122	NRL	Fiz1	4901	84922	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|role role|nmod|END_ENTITY	Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1 : possible role of Fiz1 as a transcriptional repressor .
23956131	0	NRL	65,68	optineurin	20,30	NRL	optineurin	290221(Tax:10116)	246294(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between optineurin and the bZIP transcription factor NRL .
18941128	0	NROB1	74,79	DAX-1	81,86	NROB1	DAX-1	190	190	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Three cases of congenital_adrenal_hypoplasia with novel mutations in the -LRB- NROB1 -RRB- DAX-1 gene .
21378322	0	NROB1	59,64	DAX-1	52,57	NROB1	DAX-1	190	190	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The prognostic value of the orphan nuclear receptor DAX-1 -LRB- NROB1 -RRB- in node-negative breast_cancer .
24232823	0	NROB1	36,41	DAX1	43,47	NROB1	DAX1	190	190	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Mild adrenal_insufficiency due to a NROB1 -LRB- DAX1 -RRB- gene mutation in a boy presenting an association of hypogonadotropic_hypogonadism , reduced final height and attention_deficit_disorder .
19570216	0	NRP	53,56	nucleolin_related_protein	26,51	NRP	nucleolin related protein	64556(Tax:10116)	64556(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of a novel nucleolin_related_protein -LRB- NRP -RRB- gene expressed during rat spermatogenesis .
23621014	0	NRP-1	49,54	neuropilin-1	35,47	NRP-1	neuropilin-1	8829	8829	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression and significance of neuropilin-1 -LRB- NRP-1 -RRB- on glioma cell lines and glioma tissues .
26051942	0	NRP1	0,4	CDC42	15,20	NRP1	CDC42	18186(Tax:10090)	12540(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells .
26681691	0	NRP1	29,33	HIF1a-E2F7	46,56	NRP1	HIF1a-E2F7	353246(Tax:7955)	797150;567941	Gene	Gene	START_ENTITY|nmod|target target|compound|END_ENTITY	Genome-wide analysis reveals NRP1 as a direct HIF1a-E2F7 target in the regulation of motorneuron guidance in vivo .
21059704	0	NRP1	100,104	SEMA3A	74,80	NRP1	SEMA3A	18186(Tax:10090)	20346(Tax:10090)	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Defective gonadotropin-releasing_hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2 : implications for the aetiology of hypogonadotropic_hypogonadism .
26053665	0	NRP1	50,54	SEMA3C	21,27	NRP1	SEMA3C	18186(Tax:10090)	20348(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation .
21653826	0	NRP1	112,116	VEGF	0,4	NRP1	VEGF	8829	7422	Gene	Gene	formation|nmod|START_ENTITY migration|appos|formation stimulation|nmod|migration VEGF|dobj|stimulation essential|advcl|VEGF essential|nsubj|binding binding|compound|END_ENTITY	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
21653826	0	NRP1	112,116	VEGF	38,42	NRP1	VEGF	8829	7422	Gene	Gene	formation|nmod|START_ENTITY migration|appos|formation stimulation|nmod|migration END_ENTITY|dobj|stimulation	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
21653826	0	NRP1	16,20	VEGF	0,4	NRP1	VEGF	8829	7422	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
21653826	0	NRP1	16,20	VEGF	38,42	NRP1	VEGF	8829	7422	Gene	Gene	binding|nmod|START_ENTITY essential|nsubj|binding essential|advcl|END_ENTITY	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
26573160	0	NRP1	0,4	miR-130a	20,28	NRP1	miR-130a	8829	406919	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|advcl|END_ENTITY	NRP1 is targeted by miR-130a and miR-130b , and is associated with multidrug resistance in epithelial_ovarian_cancer based on integrated gene network analysis .
15160992	0	NRP1	36,40	neuropilin_1	22,34	NRP1	neuropilin 1	8829	8829	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Overexpression of the neuropilin_1 -LRB- NRP1 -RRB- gene correlated with poor prognosis in human glioma .
27026195	0	NRP2	0,4	WDFY1	57,62	NRP2	WDFY1	8828	57590	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	NRP2 transcriptionally regulates its downstream effector WDFY1 .
17427189	0	NRP2	33,37	neuropilin-2	19,31	NRP2	neuropilin-2	8828	8828	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the neuropilin-2 -LRB- NRP2 -RRB- gene polymorphisms with autism in Chinese Han population .
18657578	0	NRSF	54,58	neuron-restrictive_silencer_factor	18,52	NRSF	neuron-restrictive silencer factor	83618(Tax:10116)	83618(Tax:10116)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Novel function of neuron-restrictive_silencer_factor -LRB- NRSF -RRB- for posttranscriptional regulation .
9856348	0	NRSF	63,67	neuron-restrictive_silencer_factor	27,61	NRSF	neuron-restrictive silencer factor	19712(Tax:10090)	19712(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	No effect of expression of neuron-restrictive_silencer_factor -LRB- NRSF -RRB- protein on N-type Ca2 + channel alpha 1B gene promoter activity in NS20Y cells .
12379233	0	NRXN3	89,94	neurexin_3	72,82	NRXN3	neurexin 3	9369	9369	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Identification and characterization of heart-specific splicing of human neurexin_3 mRNA -LRB- NRXN3 -RRB- .
18523634	0	NS1	0,3	CD8	13,16	NS1	CD8	10625	925	Gene	Gene	T-cells|nummod|START_ENTITY T-cells|compound|END_ENTITY	NS1 specific CD8 + T-cells with effector function and TRBV11 dominance in a patient with parvovirus_B19 associated inflammatory_cardiomyopathy .
16641266	0	NS1	0,3	CKII_alpha	21,31	NS1	CKII alpha	10625	1459	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	NS1 interaction with CKII_alpha : novel protein complex mediating parvovirus-induced cytotoxicity .
23311135	0	NS1	75,78	Heat_shock_protein_27	1,22	NS1	Heat shock protein 27	10625	3315	Gene	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	-LSB- Heat_shock_protein_27 enhances the inhibitory effect of influenza_A_virus NS1 on the expression of interferon-beta -RSB- .
25135490	0	NS1	26,29	Non-Structural_protein_1	0,24	NS1	Non-Structural protein 1	956024(Tax:329639)	956024(Tax:329639)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Non-Structural_protein_1 -LRB- NS1 -RRB- gene of Canine_Parvovirus-2 regresses chemically induced skin_tumors in Wistar_rats .
24899174	0	NS1	144,147	PACT	133,137	NS1	PACT	10625	8575	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Quantitative proteomic analysis of the influenza_A_virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor .
26092250	0	NS1	13,16	RPL18	62,67	NS1	RPL18	10625	6141	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	Dengue virus NS1 protein interacts with the ribosomal protein RPL18 : This interaction is required for viral translation and replication in Huh-7 cells .
19454348	0	NS1	18,21	TRIM25	51,57	NS1	TRIM25	10625	7706	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Influenza_A_virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I .
7489502	0	NS1	20,23	U6_snRNA	68,76	NS1	U6 snRNA	10625	26827	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	The influenza virus NS1 protein binds to a specific region in human U6_snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing .
11602746	0	NS1	0,3	p53	72,75	NS1	p53	1489590(Tax:10794)	7157	Gene	Gene	cell|amod|START_ENTITY cell|dep|involvement involvement|nmod|END_ENTITY	NS1 - and minute_virus_of_mice-induced cell cycle arrest : involvement of p53 and p21 -LRB- cip1 -RRB- .
23954291	0	NS1	10,13	p53	29,32	NS1	p53	5781	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes , in a promoter-dependent manner .
15367634	0	NS2	74,77	CRM1	66,70	NS2	CRM1	57762	103573(Tax:10090)	Gene	Gene	mutations|nummod|START_ENTITY END_ENTITY|nmod|mutations	Enhanced cytoplasmic sequestration of the nuclear export receptor CRM1 by NS2 mutations developed in the host regulates parvovirus fitness .
11312364	0	NS2	23,26	NEP	18,21	NEP	NEP	4311	4311	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Influenza_A_virus NEP -LRB- NS2 protein -RRB- downregulates RNA synthesis of model template RNAs .
11462009	0	NS2	29,32	NEP	24,27	NS2	NEP	57762	4311	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Influenza B and C_virus NEP -LRB- NS2 -RRB- proteins possess nuclear export activities .
9427762	0	NS2	25,28	NEP	20,23	NS2	NEP	57762	4311	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	The influenza virus NEP -LRB- NS2 protein -RRB- mediates the nuclear export of viral ribonucleoproteins .
1373202	0	NS2	113,116	VP1	168,171	NS2	VP1	57762	1489592(Tax:10794)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	The pathogenesis of infection with minute_virus_of_mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2 .
24643062	0	NS3	54,57	Caveolin-1	0,10	NS3	Caveolin-1	3845	857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Caveolin-1 in lipid rafts interacts with dengue virus NS3 during polyprotein processing and replication in HMEC-1 cells .
15303969	0	NS3	41,44	LMP7	60,64	NS3	LMP7	3845	5696	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Hepatitis_C virus non-structural protein NS3 interacts with LMP7 , a component of the immunoproteasome , and affects its proteasome activity .
15917225	0	NS3	142,145	NS5	167,170	NS3	NS5	3845	5894	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Modulation of the nucleoside triphosphatase/RNA _ helicase and 5 ' - RNA triphosphatase activities of Dengue_virus_type_2 nonstructural protein 3 -LRB- NS3 -RRB- by interaction with NS5 , the RNA-dependent RNA polymerase .
7853509	0	NS3	11,14	RNA_helicase	39,51	NS3	RNA helicase	3845	9879	Gene	Gene	possesses|nsubj|START_ENTITY possesses|dobj|activity activity|amod|END_ENTITY	Pestivirus NS3 -LRB- p80 -RRB- protein possesses RNA_helicase activity .
15294075	0	NS3	51,54	helicase	55,63	NS3	helicase	3845	164045	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	In vitro selection of RNA aptamers against the HCV NS3 helicase domain .
15294075	3	NS3	311,314	helicase	315,323	NS3	helicase	3845	164045	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	To study RNA aptamers of the NS3 helicase domain , we carried out in vitro selection against the HCV NS3 helicase domain .
18039921	0	NS3	46,49	helicase	50,58	NS3	helicase	3845	164045	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	NS3 Peptide , a novel potent hepatitis_C virus NS3 helicase inhibitor : its mechanism of action and antiviral activity in the replicon system .
11514734	0	NS3	75,78	p21	44,47	NS3	p21	3845	12575(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	p53-dependent transcriptional repression of p21 -LRB- waf1 -RRB- by hepatitis_C_virus NS3 .
16380082	0	NS3	107,110	p53	60,63	NS3	p53	3845	7157	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Single-point mutations of hepatitis_C_virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3 .
16380082	0	NS3	44,47	p53	60,63	NS3	p53	3845	7157	Gene	Gene	START_ENTITY|dobj|interaction interaction|compound|END_ENTITY	Single-point mutations of hepatitis_C_virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3 .
16690937	0	NS3	0,3	p53	71,74	NS3	p53	3845	7157	Gene	Gene	protein|nummod|START_ENTITY associates|nsubj|protein associates|nmod|END_ENTITY	NS3 protein of Hepatitis_C_virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner .
9016797	0	NS3	73,76	p53	32,35	NS3	p53	3845	7157	Gene	Gene	protein|compound|START_ENTITY accumulation|nmod|protein enhances|dobj|accumulation enhances|nsubj|END_ENTITY	Wild-type , but not mutant-type , p53 enhances nuclear accumulation of the NS3 protein of hepatitis_C_virus .
11215739	0	NS3	62,65	serine_protease	66,81	NS3	serine protease	3845	2147	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Mutations at vicinity of catalytic sites of hepatitis_C_virus NS3 serine_protease gene isolated from hepatocellular_carcinoma tissue .
25816318	0	NS5	50,53	Mitochondrial_Trifunctional_Protein	69,104	NS5	Mitochondrial Trifunctional Protein	5894	4547	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	Japanese_Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial_Trifunctional_Protein and Impairs Fatty Acid b-Oxidation .
15917225	0	NS5	167,170	NS3	142,145	NS5	NS3	5894	3845	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Modulation of the nucleoside triphosphatase/RNA _ helicase and 5 ' - RNA triphosphatase activities of Dengue_virus_type_2 nonstructural protein 3 -LRB- NS3 -RRB- by interaction with NS5 , the RNA-dependent RNA polymerase .
20363326	0	NS5	79,82	Rac1	0,4	NS5	Rac1	5894	5879	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Rac1 and Scribble are targets for the arrest of neurite outgrowth by TBE virus NS5 .
21298455	0	NS5	55,58	U1A	36,39	NS5	U1A	5894	6626	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow_fever_virus .
17010310	0	NSAP1	29,34	hnRNPQ	21,27	NSAP1	hnRNPQ	10492	10492	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The acidic domain of hnRNPQ -LRB- NSAP1 -RRB- has structural similarity to Barstar and binds to Apobec1 .
20531280	0	NSBP1	52,57	nucleosome-binding_protein_1	22,50	NSBP1	nucleosome-binding protein 1	79366	79366	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Downregulation of the nucleosome-binding_protein_1 -LRB- NSBP1 -RRB- gene can inhibit the in vitro and in vivo proliferation of prostate_cancer cells .
23785158	0	NSCL-2	8,14	gonadotropin_releasing_hormone	18,48	NSCL-2	gonadotropin releasing hormone	18072(Tax:10090)	14714(Tax:10090)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Loss of NSCL-2 in gonadotropin_releasing_hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral_obesity .
22310718	0	NSCL1	36,41	NeuroD1	0,7	NSCL1	NeuroD1	18071(Tax:10090)	18012(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	NeuroD1 is an upstream regulator of NSCL1 .
3101377	0	NSE	72,75	S-100	29,34	NSE	S-100	2026	6285	Gene	Gene	study|appos|START_ENTITY study|nmod|protein protein|compound|END_ENTITY	Immunohistochemical study of S-100 protein and neuron_specific_enolase -LRB- NSE -RRB- in melanocytes and the related tumors .
3420027	0	NSE	43,46	S-100	0,5	NSE	S-100	2026	6285	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	S-100 protein and neuron_specific_enolase -LRB- NSE -RRB- expression by chordomas in relation to the composition of their stromal mucosubstances .
21071131	0	NSE	22,25	S-100B	0,6	NSE	S-100B	2026	6285	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	S-100B is superior to NSE , BDNF and GFAP in predicting outcome of resuscitation from cardiac_arrest with hypothermia treatment .
25008877	0	NSE	36,39	erythropoietin	12,26	NSE	erythropoietin	2026	2056	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of erythropoietin on serum NSE and S-100B levels in neonates with hypoxic-ischemic_encephalopathy -RSB- .
11985791	0	NSE	48,51	neuron-specific_enolase	23,46	NSE	neuron-specific enolase	2026	2026	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of neuron-specific_enolase -LRB- NSE -RRB- in pyothorax-associated_lymphoma -LRB- PAL -RRB- .
12297981	0	NSE	82,85	neuron-specific_enolase	57,80	NSE	neuron-specific enolase	2026	2026	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Hemangiosarcoma_of_the_liver with unusual expression of neuron-specific_enolase -LRB- NSE -RRB- -RSB- .
18383893	0	NSE	67,70	neuron-specific_enolase	42,65	NSE	neuron-specific enolase	2026	2026	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Predictive and prognostic significance of neuron-specific_enolase -LRB- NSE -RRB- in non-small_cell_lung_cancer .
2092546	1	NSE	211,214	neuron-specific_enolase	186,209	NSE	neuron-specific enolase	2026	2026	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	Review of the literature and own experience with serum analysis of sialic_acid -LRB- NANA -RRB- , carcinoembryonic_antigen -LRB- CEA -RRB- and neuron-specific_enolase -LRB- NSE -RRB- -RSB- .
21165441	0	NSE	45,48	neuron-specific_enolase	20,43	NSE	neuron-specific enolase	2026	2026	Gene	Gene	Immunoreactivity|appos|START_ENTITY Immunoreactivity|nmod|END_ENTITY	Immunoreactivity of neuron-specific_enolase -LRB- NSE -RRB- in human pancreas in health and type_1_diabetes_mellitus .
24746933	0	NSE	64,67	neuron-specific_enolase	39,62	NSE	neuron-specific enolase	2026	2026	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of cerebrospinal fluid neuron-specific_enolase -LRB- NSE -RRB- in Alzheimer 's _ disease .
3039919	0	NSE	7,10	neuron-specific_enolase	12,35	NSE	neuron-specific enolase	2026	2026	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	-LSB- Serum NSE -LRB- neuron-specific_enolase -RRB- levels in small cell lung_cancer , with special reference to the measurement of serial serum NSE levels -RSB- .
3524110	1	NSE	144,147	neuron-specific_enolase	119,142	NSE	neuron-specific enolase	2026	2026	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	A comparative study with special emphasis on S-100 protein , serotonin and neuron-specific_enolase -LRB- NSE -RRB- immunoreactivity .
3587757	0	NSE	41,44	neuron-specific_enolase	16,39	NSE	neuron-specific enolase	2026	2026	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of neuron-specific_enolase -LRB- NSE -RRB- mRNA in human brain .
7825447	0	NSE	45,48	neuron-specific_enolase	20,43	NSE	neuron-specific enolase	2026	2026	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The fluctuations of neuron-specific_enolase -LRB- NSE -RRB- levels of cerebrospinal fluid during bacterial_meningitis : the relationship between the fluctuations of NSE levels and neurological complications or outcome .
9061616	0	NSE	81,84	neuron-specific_enolase	56,79	NSE	neuron-specific enolase	24334(Tax:10116)	24334(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequences in the proximal 5 ' flanking region of the rat neuron-specific_enolase -LRB- NSE -RRB- gene are sufficient for cell type-specific reporter gene expression .
1629611	0	NSE	107,110	neuron-specific_gamma_isozyme_of_human_enolase	59,105	NSE	neuron-specific gamma isozyme of human enolase	2026	2026	Gene	Gene	assay|appos|START_ENTITY assay|nmod|END_ENTITY	A simple enzyme-linked immunosorbent assay -LRB- ELISA -RRB- for the neuron-specific_gamma_isozyme_of_human_enolase -LRB- NSE -RRB- using monoclonal antibodies raised against synthetic peptides corresponding to isozyme sequence differences .
1324376	0	NSE	32,35	neuron_specific_enolase	7,30	NSE	neuron specific enolase	2026	2026	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	-LSB- Serum neuron_specific_enolase -LRB- NSE -RRB- levels in patients with non_small_cell_lung_cancer -RSB- .
6852200	0	NSE	52,55	neuron_specific_enolase	27,50	NSE	neuron specific enolase	2026	2026	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Intramural distribution of neuron_specific_enolase -LRB- NSE -RRB- in the human gastrointestinal tract .
7961908	0	NSF	66,69	ATPase	4,10	NSF	ATPase	4905	1769	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The ATPase activity of N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is regulated by soluble NSF attachment proteins .
7961908	0	NSF	95,98	ATPase	4,10	NSF	ATPase	4905	1769	Gene	Gene	proteins|compound|START_ENTITY regulated|nmod|proteins regulated|nsubjpass|activity activity|amod|END_ENTITY	The ATPase activity of N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is regulated by soluble NSF attachment proteins .
9762911	0	NSF	53,56	ATPase	43,49	NSF	ATPase	4905	1769	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of SNAP/SNARE complexes on the ATPase of NSF .
10747018	0	NSF	56,59	GATE-16	0,7	NSF	GATE-16	504457(Tax:9913)	282531(Tax:9913)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GATE-16 , a membrane transport modulator , interacts with NSF and the Golgi v-SNARE GOS-28 .
15797712	0	NSF	0,3	GluR2	53,58	NSF	GluR2	4905	2891	Gene	Gene	interaction|compound|START_ENTITY important|nsubj|interaction important|nmod|insertion insertion|nmod|END_ENTITY	NSF interaction is important for direct insertion of GluR2 at synaptic sites .
17302911	0	NSF	0,3	GluR2	73,78	NSF	GluR2	4905	2891	Gene	Gene	binds|nsubj|START_ENTITY binds|advcl|regulate regulate|nmod|END_ENTITY	NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2 .
18598260	0	NSF	43,46	GluR2	112,117	NSF	GluR2	4905	2891	Gene	Gene	N-ethylmaleimide-sensitive_fusion_protein|appos|START_ENTITY involved|nsubjpass|N-ethylmaleimide-sensitive_fusion_protein involved|nmod|switch switch|amod|END_ENTITY	N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation .
9697854	0	NSF	0,3	GluR2	15,20	NSF	GluR2	60355(Tax:10116)	29627(Tax:10116)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	NSF binding to GluR2 regulates synaptic transmission .
9697855	0	NSF	92,95	GluR2	18,23	NSF	GluR2	4905	2891	Gene	Gene	interaction|nmod|START_ENTITY mediate|dobj|interaction END_ENTITY|ccomp|mediate	The AMPA receptor GluR2 C terminus can mediate a reversible , ATP-dependent interaction with NSF and alpha - _ and_beta-SNAPs .
15204682	0	NSF	48,51	N-ethyl_maleimide_sensitive_factor	12,46	NSF	N-ethyl maleimide sensitive factor	4905	4905	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of N-ethyl_maleimide_sensitive_factor -LRB- NSF -RRB- on the acrosome of mammalian sperm .
10438719	0	NSF	63,66	N-ethylmaleimide-sensitive_fusion_protein	20,61	NSF	N-ethylmaleimide-sensitive fusion protein	4905	4905	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A critical role for N-ethylmaleimide-sensitive_fusion_protein -LRB- NSF -RRB- in platelet granule secretion .
19762473	0	NSF	98,101	alpha-SNAP	40,50	NSF	alpha-SNAP	4905	8775	Gene	Gene	N-ethylmaleimide-sensitive_factor|appos|START_ENTITY facilitates|dobj|N-ethylmaleimide-sensitive_factor facilitates|nsubj|site site|nmod|END_ENTITY	A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive_factor -LRB- NSF -RRB- - driven SNARE complex disassembly .
8620540	0	NSF	8,11	alpha-SNAP	39,49	NSF	alpha-SNAP	4905	8775	Gene	Gene	Sec18p|appos|START_ENTITY Sec18p|acl|driven driven|ccomp|precede precede|nsubj|release release|nmod|Sec17p Sec17p|appos|END_ENTITY	Sec18p -LRB- NSF -RRB- - driven release of Sec17p -LRB- alpha-SNAP -RRB- can precede docking and fusion of yeast vacuoles .
9362506	0	NSF	15,18	alpha-SNAP	38,48	NSF	alpha-SNAP	4905	8775	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis .
10400941	0	NSF	15,18	dNSF1	28,33	NSF	dNSF1	47091(Tax:7227)	47091(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Drosophila NSF protein , dNSF1 , plays a similar role at neuromuscular and some central synapses .
2968951	0	NSF	132,135	non-specific_suppressor_factor	100,130	NSF	non-specific suppressor factor	4905	4905	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Non-specific regulatory mechanism of contact sensitivity : the requirement of intermediate cells for non-specific_suppressor_factor -LRB- NSF -RRB- activity .
23926349	0	NSP4	10,14	Toll-Like_Receptor_2	84,104	NSP4	Toll-Like Receptor 2	400668	7097	Gene	Gene	Secretion|compound|START_ENTITY Secretion|nmod|END_ENTITY	Rotavirus NSP4 Triggers Secretion of Proinflammatory Cytokines from Macrophages via Toll-Like_Receptor_2 .
16501093	0	NSP4	26,30	caveolin-1	87,97	NSP4	caveolin-1	400668	857	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1 .
17379346	0	NSP4	10,14	caveolin-1	70,80	NSP4	caveolin-1	400668	857	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|- -|nmod|END_ENTITY	Rotavirus NSP4 interacts with both the amino - and carboxyl-termini of caveolin-1 .
24220211	0	NSP4	37,41	caveolin-1	75,85	NSP4	caveolin-1	400668	857	Gene	Gene	START_ENTITY|dobj|domain domain|acl:relcl|binds binds|nmod|END_ENTITY	Mutational analysis of the rotavirus NSP4 enterotoxic domain that binds to caveolin-1 .
22871651	0	NSP5	50,54	nonstructural_protein_5	25,48	NSP5	nonstructural protein 5	92521	92521	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phylogenetic analysis of nonstructural_protein_5 -LRB- NSP5 -RRB- gene sequences in porcine rotavirus B strains .
15073523	0	NSSR1	0,5	P19	69,72	NSSR1	P19	14105(Tax:10090)	83430(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	NSSR1 promotes neuronal differentiation of mouse embryonic_carcinoma P19 cells .
17215513	0	NSUN2	41,46	Aurora-B	0,8	NSUN2	Aurora-B	54888	9212	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Aurora-B regulates RNA methyltransferase NSUN2 .
26427135	0	NSUN2	70,75	MRT5	77,81	NSUN2	MRT5	54888	54888	Gene	Gene	Genes|compound|START_ENTITY Genes|appos|END_ENTITY	Frequencies of Six -LRB- Five Novel -RRB- STR Markers Linked to TUSC3 -LRB- MRT7 -RRB- or NSUN2 -LRB- MRT5 -RRB- Genes Used for Homozygosity Mapping of Recessive Intellectual_Disability .
26548545	0	NT-3	77,81	BDNF	51,55	NT-3	BDNF	4908	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Serum levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and neurotrophin-3 -LRB- NT-3 -RRB- in depressed patients with schizophrenia .
8724667	0	NT-3	0,4	BDNF	12,16	NT-3	BDNF	18205(Tax:10090)	12064(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	NT-3 and/or BDNF therapy prevents loss_of_auditory_neurons following loss of hair cells .
9582431	0	NT-3	0,4	Brn3a	29,34	NT-3	Brn3a	18205(Tax:10090)	18996(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	NT-3 regulates expression of Brn3a but not Brn3b in developing mouse trigeminal sensory neurons .
10492008	0	NT-3	9,13	CA1	90,93	NT-3	CA1	81737(Tax:10116)	310218(Tax:10116)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Neuronal NT-3 is not required for synaptic transmission or long-term potentiation in area CA1 of the adult rat hippocampus .
21151544	0	NT-3	40,44	Neurotrophin-3	24,38	NT-3	Neurotrophin-3	4908	4908	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Placental Neurotrophin-3 -LRB- NT-3 -RRB- in Physiological Pregnancy , Preeclampsia_and_Chorioamnionitis .
7955419	0	NT-3	16,20	Neurotrophin-3	0,14	NT-3	Neurotrophin-3	81737(Tax:10116)	81737(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Neurotrophin-3 -LRB- NT-3 -RRB- levels in the developing rat nervous system and in human samples .
10632603	0	NT-3	83,87	neurotrophin-3	14,28	NT-3	neurotrophin-3	428099(Tax:9031)	428099(Tax:9031)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of neurotrophin-3 -LRB- NT-3 -RRB- and anterograde axonal transport of endogenous NT-3 by retinal ganglion cells in chick embryos .
20178830	0	NT-3	31,35	neurotrophin-3	15,29	NT-3	neurotrophin-3	18205(Tax:10090)	18205(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of neurotrophin-3 -LRB- NT-3 -RRB- in the functional elimination of synaptic contacts during neuromuscular development .
8366347	0	NT-3	121,125	neurotrophin-3	105,119	NT-3	neurotrophin-3	81737(Tax:10116)	81737(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Cholinergic regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- mRNA levels in the developing rat hippocampus .
8837968	0	NT-3	42,46	neurotrophin-3	26,40	NT-3	neurotrophin-3	4908	4908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An association study of a neurotrophin-3 -LRB- NT-3 -RRB- gene polymorphism with schizophrenia .
12905890	0	NT-4	30,34	neurotrophin-4	15,29	NT-4	neurotrophin-4	4909	4909	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Expression of neurotrophin-4 -LRB- NT-4 -RRB- gene in baculovirus expression vector system -RSB- .
10051762	0	NT3	153,156	BDNF	127,131	NT3	BDNF	4908	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Distinct populations of hypothalamic dopaminergic neurons exhibit differential responses to brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and neurotrophin-3 -LRB- NT3 -RRB- .
24224958	0	NT3	15,18	NTR	27,30	NT3	NTR	18205(Tax:10090)	18053(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of NT3 and P75 -LRB- NTR -RRB- in photoreceptor_degeneration following selective M ller cell ablation .
10756065	0	NT3	44,47	neurotrophin-3	28,42	NT3	neurotrophin-3	18205(Tax:10090)	18205(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Cutaneous overexpression of neurotrophin-3 -LRB- NT3 -RRB- selectively restores sensory innervation in NT3 gene knockout mice .
15703301	0	NT4	56,59	neuropeptide_Y	27,41	NT4	neuropeptide Y	4909	4852	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Transcellular induction of neuropeptide_Y expression by NT4 and BDNF .
24688028	0	NTB-A	53,58	LCK	46,49	NTB-A	LCK	114836	3932	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced_cell_death .
15162436	0	NTBA	26,30	CD2	48,51	NTBA	CD2	114836	914	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Homophilic interaction of NTBA , a member of the CD2 molecular family : induction of cytotoxicity and cytokine release in human NK cells .
16218878	0	NTCP	67,71	sodium_taurocholate_cotransporting_polypeptide	19,65	NTCP	sodium taurocholate cotransporting polypeptide	6554	6554	Gene	Gene	Degradation|appos|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of the sodium_taurocholate_cotransporting_polypeptide -LRB- NTCP -RRB- by the ubiquitin-proteasome system .
23418070	0	NTE	71,74	neuropathy_target_esterase	43,69	NTE	neuropathy target esterase	10908	10908	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Association of sick_building_syndrome with neuropathy_target_esterase -LRB- NTE -RRB- activity in Japanese .
25255935	0	NTE	53,56	neuropathy_target_esterase	25,51	NTE	neuropathy target esterase	10908	10908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Silencing of PNPLA6 , the neuropathy_target_esterase -LRB- NTE -RRB- codifying gene , alters neurodifferentiation of human embryonal_carcinoma stem cells -LRB- NT2 -RRB- .
8343996	0	NTE	33,36	neurotoxic_esterase	12,31	NTE	neurotoxic esterase	425396(Tax:9031)	425396(Tax:9031)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of neurotoxic_esterase -LRB- NTE -RRB- in the prevention and potentiation of organophosphorus-induced delayed neurotoxicity -LRB- OPIDN -RRB- .
20153340	0	NTN	89,92	GDNF	68,72	NTN	GDNF	84423(Tax:10116)	25453(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Pharmacokinetics and bioactivity of glial cell line-derived factor -LRB- GDNF -RRB- and neurturin -LRB- NTN -RRB- infused into the rat brain .
10366627	0	NTN2L	35,40	Netrin-3	0,8	NTN2L	Netrin-3	4917	18209(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Netrin-3 , a mouse homolog of human NTN2L , is highly expressed in sensory ganglia and shows differential binding to netrin receptors .
15852226	0	NTPDase-1	14,23	CD39	8,12	NTPDase-1	CD39	12495(Tax:10090)	12495(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of CD39 -LRB- NTPDase-1 -RRB- in thromboregulation , cerebroprotection , and cardioprotection .
21670316	0	NTPDase1	0,8	IL-8	18,22	NTPDase1	IL-8	953	3576	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|compound|END_ENTITY	NTPDase1 controls IL-8 production by human neutrophils .
18202114	0	NTPDase2	36,44	IL-6	0,4	NTPDase2	IL-6	64467(Tax:10116)	24498(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY downregulates|dobj|transcription downregulates|nsubj|END_ENTITY	IL-6 downregulates transcription of NTPDase2 via specific promoter elements .
18693757	0	NTPDase3	112,120	ATPase	30,36	NTPDase3	ATPase	956	1769	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding .
18693757	0	NTPDase3	73,81	ATPase	30,36	NTPDase3	ATPase	956	1769	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding .
18693757	0	NTPDase3	112,120	NTPDase3	73,81	NTPDase3	NTPDase3	956	956	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding .
18693757	0	NTPDase3	73,81	NTPDase3	112,120	NTPDase3	NTPDase3	956	956	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3 and the effect of ER-targeted NTPDase3 on protein folding .
20682839	0	NTPDase3	112,120	insulin	124,131	NTPDase3	insulin	956	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Identification of the ectonucleotidases expressed in mouse , rat , and human Langerhans islets : potential role of NTPDase3 in insulin secretion .
15698960	0	NTPDase5	76,84	CD39L4	86,92	NTPDase5	CD39L4	957	957	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Bacterial expression , folding , purification and characterization of soluble NTPDase5 -LRB- CD39L4 -RRB- ecto-nucleotidase .
17037982	0	NTPase	57,63	centaurin_gamma-1	4,21	NTPase	centaurin gamma-1	84284	116986	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	The centaurin_gamma-1 GTPase-like domain functions as an NTPase .
24224958	0	NTR	27,30	NT3	15,18	NTR	NT3	18053(Tax:10090)	18205(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of NT3 and P75 -LRB- NTR -RRB- in photoreceptor_degeneration following selective M ller cell ablation .
10773744	5	NTR	1020,1023	p75	1016,1019	NTR	p75	4923	11168	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	For this purpose , we studied paraffin sections of the SON in 32 postmortem brains of control patients ranging in age from 29 to 94 years with an anti-p75 -LRB- NTR -RRB- antibody and determined the area of p75 -LRB- NTR -RRB- immunoreactivity per neuron using an image analysis system .
11042591	0	NTR	15,18	p75	11,14	NTR	p75	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Absence of p75 -LRB- NTR -RRB- expression reduces nerve_growth_factor immunolocalization in cholinergic septal neurons .
11398197	0	NTR	46,49	p75	42,45	NTR	p75	4923	7133	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Molecular characterization of the loss of p75 -LRB- NTR -RRB- expression in human prostate_tumor cells .
11451944	0	NTR	26,29	p75	22,25	NTR	p75	4923	7133	Gene	Gene	apoptotic|appos|START_ENTITY apoptotic|amod|END_ENTITY	Characterization of a p75 -LRB- NTR -RRB- apoptotic signaling pathway using a novel cellular model .
11992464	0	NTR	18,21	p75	14,17	NTR	p75	4923	11168	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Dual role for p75 -LRB- NTR -RRB- signaling in survival and cell death : can intracellular mediators provide an explanation ?
18055214	0	NTR	49,52	p75	45,48	NTR	p75	4923	11168	Gene	Gene	regulates|dep|START_ENTITY regulates|nsubj|Palmitoylation Palmitoylation|nmod|fragment fragment|nmod|END_ENTITY	Palmitoylation of the C-terminal fragment of p75 -LRB- NTR -RRB- regulates death signaling and is required for subsequent cleavage by gamma-secretase .
18196575	0	NTR	8,11	p75	4,7	NTR	p75	4923	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The p75 NTR neurotrophin receptor is a tumor suppressor in human and murine retinoblastoma development .
18378044	0	NTR	49,52	p75	45,48	NTR	p75	4923	11168	Gene	Gene	switch|appos|START_ENTITY switch|amod|END_ENTITY	Egr-1 and Hipk2 are required for the TrkA to p75 -LRB- NTR -RRB- switch that occurs downstream of IGF1-R .
18602709	0	NTR	4,7	p75	0,3	NTR	p75	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	p75 -LRB- NTR -RRB- activation of NF-kappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells .
19156869	0	NTR	4,7	p75	0,3	NTR	p75	4923	7133	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	p75 NTR expression is induced in isolated neurons of the penumbra after ischemia by cortical_devascularization .
19156869	14	NTR	1673,1676	p75	1669,1672	NTR	p75	4923	7133	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	In primary neuronal culture , it is clear that excitotoxicity and Sp1 are involved in induction of p75 -LRB- NTR -RRB- expression , although , in vivo , some additional mechanisms are likely to be involved in the control of p75 -LRB- NTR -RRB- expression in specific neurons in vivo .
19156869	5	NTR	667,670	p75	663,666	NTR	p75	4923	7133	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	In this study , we analyzed the spatiotemporal profile of p75 -LRB- NTR -RRB- expression after an ischemic_lesion induced by cortical_devascularization -LRB- CD -RRB- .
20659559	0	NTR	128,131	p75	124,127	NTR	p75	4923	11168	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75 -LRB- NTR -RRB- antagonists .
21658451	0	NTR	4,7	p75	0,3	NTR	p75	4923	11168	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p75 -LRB- NTR -RRB- expression and nuclear localization of p75 -LRB- NTR -RRB- intracellular_domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation .
21658451	0	NTR	52,55	p75	48,51	NTR	p75	4923	11168	Gene	Gene	intracellular_domain|appos|START_ENTITY intracellular_domain|amod|END_ENTITY	p75 -LRB- NTR -RRB- expression and nuclear localization of p75 -LRB- NTR -RRB- intracellular_domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation .
26057084	0	NTR	28,31	p75	24,27	NTR	p75	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Merlin status regulates p75 -LRB- NTR -RRB- expression and apoptotic signaling in Schwann cells following nerve_injury .
26119933	0	NTR	63,66	p75	32,35	NTR	p75	4923	7133	Gene	Gene	p75|appos|START_ENTITY Glioma_invasion|appos|p75 Glioma_invasion|acl|mediated mediated|nmod|receptor receptor|amod|END_ENTITY	Glioma_invasion mediated by the p75 neurotrophin receptor -LRB- p75 -LRB- NTR -RRB- / CD271 -RRB- requires regulated interaction with PDLIM1 .
26297037	0	NTR	56,59	p75	52,55	NTR	p75	4923	7133	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|compound|END_ENTITY	SORT1 Mutation Resulting in Sortilin Deficiency and p75 -LRB- NTR -RRB- Upregulation in a Family With Essential_Tremor .
27047921	0	NTR	33,36	p75	29,32	NTR	p75	4923	11168	Gene	Gene	SOX10/CD271|appos|START_ENTITY SOX10/CD271|dep|END_ENTITY	Coexpression of SOX10/CD271 -LRB- p75 -LRB- NTR -RRB- -RRB- and b-Galactosidase in Large to Giant Congenital Melanocytic Nevi of Pediatric Patients .
23407681	0	NTR-3	34,39	Sortilin_1	22,32	NTR-3	Sortilin 1	6272	6272	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Ectopic Expression of Sortilin_1 -LRB- NTR-3 -RRB- in Patients with Ovarian_Carcinoma .
15733655	0	NTR1	30,34	Neurotensin	0,11	NTR1	Neurotensin	4923	4922	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive .
19470473	0	NTRC	0,4	thioredoxin	20,31	NTRC	thioredoxin	818766(Tax:3702)	824267(Tax:3702)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	NTRC links built-in thioredoxin to light and sucrose in regulating starch synthesis in chloroplasts and amyloplasts .
10330344	0	NTRK1	79,84	TRKA	73,77	NTRK1	TRKA	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Congenital_insensitivity_to_pain_with_anhidrosis : novel mutations in the TRKA -LRB- NTRK1 -RRB- gene encoding a high-affinity receptor for nerve_growth_factor .
10982191	0	NTRK1	48,53	TRKA	42,46	NTRK1	TRKA	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation and polymorphism analysis of the TRKA -LRB- NTRK1 -RRB- gene encoding a high-affinity receptor for nerve growth factor in congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- families .
11071380	0	NTRK1	100,105	TRKA	94,98	NTRK1	TRKA	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with congenital_insensitivity_to_pain_with_anhidrosis .
11668614	0	NTRK1	86,91	TRKA	80,84	NTRK1	TRKA	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Congenital_insensitivity_to_pain_with_anhidrosis -LRB- CIPA -RRB- : novel mutations of the TRKA -LRB- NTRK1 -RRB- gene , a putative uniparental_disomy , and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate_kinase_deficiency .
11748840	0	NTRK1	113,118	TRKA	107,111	NTRK1	TRKA	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular basis of congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : mutations and polymorphisms in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve_growth_factor .
12102460	1	NTRK1	188,193	TRKA	183,187	NTRK1	TRKA	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Clinical , biological and molecular aspects of mutations in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve growth factor .
12210794	0	NTRK1	25,30	TRKA	19,23	NTRK1	TRKA	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No mutation in the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with hereditary_sensory_and_autonomic_neuropathy_type_V .
11310631	0	NTRK1	15,20	TRK_A	8,13	NTRK1	TRK A	4914	4914	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A novel TRK_A -LRB- NTRK1 -RRB- mutation associated with hereditary_sensory_and_autonomic_neuropathy_type_V .
16373086	0	NTRK1	101,106	neurotrophic_tyrosine_kinase_receptor_type_1	50,94	NTRK1	neurotrophic tyrosine kinase receptor type 1	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel frameshift and splice site mutations in the neurotrophic_tyrosine_kinase_receptor_type_1 gene -LRB- NTRK1 -RRB- associated with hereditary_sensory_neuropathy_type_IV .
18077166	0	NTRK1	107,112	neurotrophic_tyrosine_kinase_receptor_type_1	56,100	NTRK1	neurotrophic tyrosine kinase receptor type 1	4914	4914	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel missense , insertion and deletion mutations in the neurotrophic_tyrosine_kinase_receptor_type_1 gene -LRB- NTRK1 -RRB- associated with congenital insensitivity_to_pain with anhidrosis .
23315174	0	NTRK2	46,51	Neurotrophic_tyrosine_kinase_receptor_type_2	0,44	NTRK2	Neurotrophic tyrosine kinase receptor type 2	4915	4915	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Neurotrophic_tyrosine_kinase_receptor_type_2 -LRB- NTRK2 -RRB- gene associated with treatment response to mood stabilizers in patients with bipolar_I_disorder .
16713586	0	NTRK2	84,89	neurotrophic_tyrosine_kinase_receptor_2	38,77	NTRK2	neurotrophic tyrosine kinase receptor 2	4915	4915	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of specific haplotypes of neurotrophic_tyrosine_kinase_receptor_2 gene -LRB- NTRK2 -RRB- with vulnerability to nicotine_dependence in African-Americans and European-Americans .
17918233	0	NTRK2	69,74	neurotrophic_tyrosine_kinase_receptor_type_2	23,67	NTRK2	neurotrophic tyrosine kinase receptor type 2	4915	4915	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Genetic association of neurotrophic_tyrosine_kinase_receptor_type_2 -LRB- NTRK2 -RRB- With Alzheimer 's _ disease .
12210087	0	NTRK3	25,30	TrkC	19,23	NTRK3	TrkC	4916	4916	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression of TrkC -LRB- NTRK3 -RRB- in human soft tissue tumours .
18347002	0	NTRK3	60,65	neurotrophic_tyrosine_kinase_receptor_3	19,58	NTRK3	neurotrophic tyrosine kinase receptor 3	4916	4916	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the neurotrophic_tyrosine_kinase_receptor_3 -LRB- NTRK3 -RRB- gene and childhood-onset mood_disorders .
8682498	0	NTRK4	18,23	trkE	25,29	NTRK4	trkE	780	780	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the NTRK4 -LRB- trkE -RRB- gene to chromosome 6p21 .
17116165	0	NTS1	56,60	neurotensin	44,55	NTS1	neurotensin	102467591	67405(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons .
22504145	0	NTS1	0,4	neurotensin	42,53	NTS1	neurotensin	102467591	67405(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|analgesia analgesia|nmod|treatment treatment|amod|END_ENTITY	NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral_pain .
22778874	0	NTS1	65,69	neurotensin	53,64	NTS1	neurotensin	4922	4922	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics .
21394204	0	NTSR1	29,34	Neurotensin	0,11	NTSR1	Neurotensin	4923	4922	Gene	Gene	gene|appos|START_ENTITY polymorphism|nsubj|gene receptor|acl:relcl|polymorphism receptor|compound|END_ENTITY	Neurotensin receptor 1 gene -LRB- NTSR1 -RRB- polymorphism is associated with working memory .
25644759	0	NTSR1	65,70	Neurotensin	0,11	NTSR1	Neurotensin	4923	4922	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Neurotensin promotes the progression of malignant_glioma through NTSR1 and impacts the prognosis of glioma patients .
25644759	0	NTSR1	65,70	Neurotensin	0,11	NTSR1	Neurotensin	4923	4922	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Neurotensin promotes the progression of malignant_glioma through NTSR1 and impacts the prognosis of glioma patients .
11032391	0	NTSR1	45,50	neurotensin	18,29	NTSR1	neurotensin	4923	4922	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The high affinity neurotensin receptor gene -LRB- NTSR1 -RRB- : comparative sequencing and association studies in schizophrenia .
23109725	0	NTSR1	63,68	neurotensin	27,38	NTSR1	neurotensin	4923	4922	Gene	Gene	expression|appos|START_ENTITY expression|nmod|receptors receptors|amod|END_ENTITY	Differential expression of neurotensin and specific receptors , NTSR1 and NTSR2 , in normal and malignant human B lymphocytes .
27081712	0	NUAK2	47,52	miR-143	0,7	NUAK2	miR-143	81788	406935	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma .
11585840	0	NUB1	69,73	NEDD8	13,18	NUB1	NEDD8	51667	4738	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 .
16171779	0	NUB1	15,19	S5a	48,51	NUB1	S5a	51667	5710	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of NUB1 with the proteasome subunit S5a .
26260793	0	NUB1L	30,35	NEDD8_Ultimate_Buster_1	0,23	NUB1L	NEDD8 Ultimate Buster 1	51667	51667	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	NEDD8_Ultimate_Buster_1 Long -LRB- NUB1L -RRB- Protein Suppresses Atypical Neddylation and Promotes the Proteasomal Degradation of Misfolded Proteins .
25038744	0	NUCB1	30,35	nucleobindin_1	14,28	NUCB1	nucleobindin 1	18220(Tax:10090)	18220(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of nucleobindin_1 -LRB- NUCB1 -RRB- in pancreatic islets and other endocrine tissues .
25949163	0	NUCB2	25,30	Nesfatin-1	14,24	NUCB2	Nesfatin-1	53322(Tax:10090)	53322(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of Nesfatin-1 / NUCB2 in Fetal , Neonatal and Adult Mice .
20380005	0	NUCB2	25,30	nesfatin-1	14,24	NUCB2	nesfatin-1	59295(Tax:10116)	59295(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of nesfatin-1 / NUCB2 in rodent digestive system .
25344190	0	NUCB2	26,31	nesfatin-1	15,25	NUCB2	nesfatin-1	59295(Tax:10116)	59295(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of nesfatin-1 / NUCB2 and ghrelin in gastric mucosa of rats with intrauterine_growth_retardation -RSB- .
26369257	0	NUCB2	0,5	nesfatin-1	50,60	NUCB2	nesfatin-1	4925	4925	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	NUCB2 gene polymorphism and its relationship with nesfatin-1 levels in polycystic_ovary_syndrome .
23266808	0	NUCB2	42,47	nucleobindin_2	21,35	NUCB2	nucleobindin 2	4925	4925	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association of a nucleobindin_2 gene -LRB- NUCB2 -RRB- variant with childhood adiposity .
22200976	0	NUDT5	22,27	nudix_type_5	8,20	NUDT5	nudix type 5	11164	11164	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Lowered nudix_type_5 -LRB- NUDT5 -RRB- expression leads to cell cycle retardation in HeLa cells .
25701787	0	NUF2	88,92	Heterogeneous_nuclear_ribonucleoprotein_K	0,41	NUF2	Heterogeneous nuclear ribonucleoprotein K	83540	3190	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon_cancer cells .
17535814	0	NUF2	6,10	centromere-associated_protein_E	26,57	NUF2	centromere-associated protein E	83540	1062	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human NUF2 interacts with centromere-associated_protein_E and is essential for a stable spindle microtubule-kinetochore attachment .
15107825	0	NUFIP	22,27	BRCA1	0,5	NUFIP	BRCA1	26747	672	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II .
26366217	0	NUMB	31,35	HDM2	83,87	NUMB	HDM2	8650	4193	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	The Expression and Function of NUMB in Endometrial_Cancer and the Interaction with HDM2 and P53 .
20079715	0	NUMBL	0,5	TRAF6	21,26	NUMBL	TRAF6	9253	7189	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	NUMBL interacts with TRAF6 and promotes the degradation of TRAF6 .
12034489	0	NUP155	97,103	nucleoporin_155	80,95	NUP155	nucleoporin 155	9631	9631	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization , transcript variants and comparative analysis of the human nucleoporin_155 -LRB- NUP155 -RRB- gene .
12112533	0	NUP98	97,102	HOXA	115,119	NUP98	HOXA	4928	3197	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	The chromosome translocation t -LRB- 7 ; 11 -RRB- -LRB- p15 ; p15 -RRB- in acute_myeloid_leukemia results in fusion of the NUP98 gene with a HOXA cluster gene , HOXA13 , but not HOXA9 .
9166830	0	NUP98	140,145	nucleoporin	122,133	NUP98	nucleoporin	4928	3268	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The inv -LRB- 11 -RRB- -LRB- p15q22 -RRB- chromosome translocation of de novo and therapy-related myeloid_malignancies results in fusion of the nucleoporin gene , NUP98 , with the putative RNA helicase gene , DDX10 .
19153668	0	NUPR1	36,41	nuclear_protein_1	17,34	NUPR1	nuclear protein 1	100912108	100912108	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Emerging role of nuclear_protein_1 -LRB- NUPR1 -RRB- in cancer biology .
18690848	0	NUPR1	0,5	p53	21,24	NUPR1	p53	26471	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	NUPR1 interacts with p53 , transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic_stress .
26874000	0	NUR77	21,26	KLF6	0,4	NUR77	KLF6	3164	1316	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 Leydig cells .
18599618	0	NUR77	28,33	StAR	60,64	NUR77	StAR	3164	6770	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2 + / calmodulin-dependent protein kinase I. Cholesterol transport in the mitochondrial membrane , an essential step of steroid biosynthesis , is mediated by a protein complex containing the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
22551568	0	NUR77	0,5	TIMP2	33,38	NUR77	TIMP2	3164	7077	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8 / SVneo cells induced by CYR61 .
20829434	0	NURR1	18,23	MIF	41,44	NURR1	MIF	4929	4282	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Identification of NURR1 as a mediator of MIF signaling during chronic arthritis : effects on glucocorticoid-induced MKP1 .
11884470	0	NURR1	38,43	NF-kappa_B	61,71	NURR1	NF-kappa B	4929	4790	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Activation of nuclear orphan receptor NURR1 transcription by NF-kappa_B and cyclic_adenosine_5 ' - monophosphate response element-binding protein in rheumatoid_arthritis synovial tissue .
14988426	0	NURR1	66,71	osteopontin	18,29	NURR1	osteopontin	18227(Tax:10090)	20750(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts .
24681825	0	NWD1	24,28	androgen_receptor	78,95	NWD1	androgen receptor	284434	367	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The NLR-related protein NWD1 is associated with prostate_cancer and modulates androgen_receptor signaling .
16567619	0	NXP-2	0,5	SUMO-2	23,29	NXP-2	SUMO-2	23515	6613	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression .
15600300	0	NY-ESO-1	35,43	CD25	96,100	NY-ESO-1	CD25	246100	3559	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
10878395	0	NY-ESO-1	44,52	CD4	18,21	NY-ESO-1	CD4	246100	920	Gene	Gene	epitopes|nmod|START_ENTITY epitopes|nsubj|Identification Identification|nmod|cell cell|compound|END_ENTITY	Identification of CD4 + T cell epitopes from NY-ESO-1 presented by HLA-DR molecules .
10987311	0	NY-ESO-1	0,8	CD4	79,82	NY-ESO-1	CD4	246100	920	Gene	Gene	encodes|compound|START_ENTITY DRB1|nsubj|encodes DRB1|dep|epitopes epitopes|acl|recognized recognized|nmod|cells cells|compound|END_ENTITY	NY-ESO-1 encodes DRB1 * 0401-restricted epitopes recognized by melanoma-reactive CD4 + T cells .
11259659	0	NY-ESO-1	134,142	CD4	0,3	NY-ESO-1	CD4	246100	920	Gene	Gene	production|compound|START_ENTITY association|nmod|production allele|dep|association presented|nmod|allele NY-ESO-1|acl|presented T|nmod|NY-ESO-1 T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele : association with NY-ESO-1 antibody production .
11259659	0	NY-ESO-1	67,75	CD4	0,3	NY-ESO-1	CD4	246100	920	Gene	Gene	T|nmod|START_ENTITY T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cell recognition of MHC class II-restricted epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele : association with NY-ESO-1 antibody production .
12853579	0	NY-ESO-1	60,68	CD4	30,33	NY-ESO-1	CD4	246100	920	Gene	Gene	responses|nmod|START_ENTITY Survey|dep|responses Survey|nmod|T T|compound|END_ENTITY	Survey of naturally occurring CD4 + T cell responses against NY-ESO-1 in cancer patients : correlation with antibody responses .
15197261	0	NY-ESO-1	82,90	CD4	15,18	NY-ESO-1	CD4	246100	920	Gene	Gene	vaccinated|nmod|START_ENTITY patient|acl|vaccinated identified|nmod|patient identified|nsubj|responses responses|compound|END_ENTITY	Immunodominant CD4 + responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant .
15600300	0	NY-ESO-1	35,43	CD4	91,94	NY-ESO-1	CD4	246100	920	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|CD25 CD25|compound|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
16152624	0	NY-ESO-1	22,30	CD4	54,57	NY-ESO-1	CD4	246100	920	Gene	Gene	epitopes|compound|START_ENTITY Identification|nmod|epitopes recognized|nsubj|Identification recognized|nmod|cells cells|compound|END_ENTITY	Identification of new NY-ESO-1 epitopes recognized by CD4 + T cells and presented by HLA-DQ_B1 03011 .
18565862	0	NY-ESO-1	70,78	CD4	49,52	NY-ESO-1	CD4	246100	920	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|cells cells|compound|END_ENTITY	Treatment of metastatic_melanoma with autologous CD4 + T cells against NY-ESO-1 .
19531622	0	NY-ESO-1	29,37	CD4	90,93	NY-ESO-1	CD4	246100	920	Gene	Gene	protein|compound|START_ENTITY Vaccination|nmod|protein elicits|nsubj|Vaccination elicits|dobj|responses responses|compound|END_ENTITY	Vaccination with recombinant NY-ESO-1 protein elicits immunodominant HLA-DR52b-restricted CD4 + T cell responses with a conserved T cell receptor repertoire .
20368442	0	NY-ESO-1	14,22	CD4	32,35	NY-ESO-1	CD4	246100	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Monitoring of NY-ESO-1 specific CD4 + T cells using molecularly defined MHC class II/His-tag-peptide tetramers .
20665979	0	NY-ESO-1	12,20	CD4	88,91	NY-ESO-1	CD4	246100	920	Gene	Gene	epitopes|nsubj|START_ENTITY epitopes|parataxis|recognized recognized|nmod|cells cells|compound|END_ENTITY	Three novel NY-ESO-1 epitopes bound to DRB1 * 0803 , DQB1 * 0401 and DRB1 * 0901 recognized by CD4 T cells from CHP-NY-ESO-1-vaccinated patients .
20670945	0	NY-ESO-1	118,126	CD4	30,33	NY-ESO-1	CD4	246100	920	Gene	Gene	region|nmod|START_ENTITY T|nmod|region T|nsubj|Assessment Assessment|nmod|END_ENTITY	Assessment of vaccine-induced CD4 T cell responses to the 119-143 immunodominant region of the tumor-specific antigen NY-ESO-1 using DRB1 * 0101 tetramers .
24777968	0	NY-ESO-1	48,56	CD4	0,3	NY-ESO-1	CD4	246100	920	Gene	Gene	effectors|nmod|START_ENTITY effectors|compound|END_ENTITY	CD4 + T effectors specific for the tumor antigen NY-ESO-1 are highly enriched at ovarian_cancer sites and coexist with , but are distinct from , tumor-associated Treg .
25662405	0	NY-ESO-1	79,87	CD4	52,55	NY-ESO-1	CD4	246100	920	Gene	Gene	vaccine|compound|START_ENTITY responses|nmod|vaccine responses|amod|END_ENTITY	Low-dose cyclophosphamide enhances antigen-specific CD4 -LRB- + -RRB- T cell responses to NY-ESO-1 / ISCOMATRIX vaccine in patients with advanced melanoma .
26587312	0	NY-ESO-1	34,42	CD4	0,3	NY-ESO-1	CD4	246100	920	Gene	Gene	antigen|compound|START_ENTITY responses|nmod|antigen resist|nsubj|responses T|ccomp|resist T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T helper cell responses to NY-ESO-1 tumor antigen in ovarian_cancer resist perversion into immunosuppressive Tregs .
26608910	0	NY-ESO-1	18,26	CD4	76,79	NY-ESO-1	CD4	246100	920	Gene	Gene	Mediates|nsubj|START_ENTITY Mediates|nmod|Cells Cells|compound|END_ENTITY	The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4 + T Cells after Intercellular Antigen Transfer .
10781081	0	NY-ESO-1	35,43	CD8	11,14	NY-ESO-1	CD8	246100	925	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Monitoring CD8 T cell responses to NY-ESO-1 : correlation of humoral and cellular immune responses .
10969798	0	NY-ESO-1	109,117	CD8	59,62	NY-ESO-1	CD8	246100	925	Gene	Gene	occurring|nsubj|START_ENTITY occurring|dobj|response response|compound|END_ENTITY	Naturally occurring human lymphocyte antigen-A2 restricted CD8 + T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients .
11027314	0	NY-ESO-1	117,125	CD8	40,43	NY-ESO-1	CD8	246100	925	Gene	Gene	cancers|compound|START_ENTITY patients|nmod|cancers lymphocyte|nmod|patients lymphocyte|compound|END_ENTITY	Induction of primary NY-ESO-1 immunity : CD8 + T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1 + cancers .
11027314	0	NY-ESO-1	21,29	CD8	40,43	NY-ESO-1	CD8	246100	925	Gene	Gene	immunity|compound|START_ENTITY Induction|nmod|immunity Induction|dep|lymphocyte lymphocyte|compound|END_ENTITY	Induction of primary NY-ESO-1 immunity : CD8 + T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1 + cancers .
11300471	0	NY-ESO-1	24,32	CD8	0,3	NY-ESO-1	CD8	246100	925	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	CD8 + T-cell response to NY-ESO-1 : relative antigenicity and in vitro immunogenicity of natural and analogue sequences .
12186971	0	NY-ESO-1	72,80	CD8	0,3	NY-ESO-1	CD8	246100	925	Gene	Gene	immunization|compound|START_ENTITY T|nmod|immunization T|nsubj|END_ENTITY	CD8 -LRB- + -RRB- T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients .
12488431	0	NY-ESO-1	41,49	CD8	13,16	NY-ESO-1	CD8	246100	925	Gene	Gene	peptide|amod|START_ENTITY results|amod|peptide T|nmod|results T|nsubj|END_ENTITY	Multiepitope CD8 -LRB- + -RRB- T cell response to a NY-ESO-1 peptide vaccine results in imprecise tumor targeting .
12747757	0	NY-ESO-1	40,48	CD8	71,74	NY-ESO-1	CD8	246100	925	Gene	Gene	peptide|compound|START_ENTITY Identification|nmod|peptide recognized|nsubj|Identification recognized|nmod|cells cells|compound|END_ENTITY	Identification of a naturally processed NY-ESO-1 peptide recognized by CD8 + T cells in the context of HLA-B51 .
15600300	0	NY-ESO-1	35,43	CD8	102,105	NY-ESO-1	CD8	246100	925	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	HLA-DP4 expression and immunity to NY-ESO-1 : correlation and characterization of cytotoxic CD4 + CD25 - CD8 - T cell clones .
15838382	0	NY-ESO-1	134,142	CD8	82,85	NY-ESO-1	CD8	246100	925	Gene	Gene	occurring|nmod|START_ENTITY occurring|nmod|responses responses|compound|END_ENTITY	Distinct structural TCR repertoires in naturally occurring versus vaccine-induced CD8 + T-cell responses to the tumor-specific antigen NY-ESO-1 .
16378102	0	NY-ESO-1	18,26	CD8	74,77	NY-ESO-1	CD8	246100	925	Gene	Gene	cell|compound|START_ENTITY Estimation|nmod|cell line|nsubj|Estimation line|nmod|cells cells|compound|END_ENTITY	-LSB- Estimation of an NY-ESO-1 expressing HCC cell line by NY-ESO-1b specific CD8 + T cells in vitro induced by HLA-A2 restricted NY-ESO-1b peptide -RSB- .
16670298	0	NY-ESO-1	106,114	CD8	58,61	NY-ESO-1	CD8	246100	925	Gene	Gene	T|nmod|START_ENTITY T|nsubj|hierarchy hierarchy|nmod|+ +|compound|END_ENTITY	Striking immunodominance hierarchy of naturally occurring CD8 + and CD4 + T cell responses to tumor antigen NY-ESO-1 .
17294444	0	NY-ESO-1	0,8	CD8	89,92	NY-ESO-1	CD8	246100	925	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|T-cell T-cell|compound|END_ENTITY	NY-ESO-1 protein expression in primary breast_carcinoma and metastases : correlation with CD8 + T-cell and CD79a + plasmacytic/B-cell infiltration .
17640060	0	NY-ESO-1	52,60	CD8	15,18	NY-ESO-1	CD8	246100	925	Gene	Gene	vaccination|compound|START_ENTITY +|nmod|vaccination +|nsubj|END_ENTITY	Tumor-reactive CD8 + T-cell clones in patients after NY-ESO-1 peptide vaccination .
18253733	0	NY-ESO-1	137,145	CD8	63,66	NY-ESO-1	CD8	246100	925	Gene	Gene	region|nmod|START_ENTITY reactive|nmod|region reactive|dobj|epitopes epitopes|nummod|END_ENTITY	Recognition of naturally processed and ovarian_cancer reactive CD8 + T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1 .
19728336	0	NY-ESO-1	60,68	CD8	15,18	NY-ESO-1	CD8	246100	925	Gene	Gene	peptide|compound|START_ENTITY +|nmod|peptide +|nsubj|END_ENTITY	Tumor-reactive CD8 + T-cell responses after vaccination with NY-ESO-1 peptide , CpG_7909 and Montanide ISA-51 : association with survival .
21149605	0	NY-ESO-1	18,26	CD8	86,89	NY-ESO-1	CD8	246100	925	Gene	Gene	elicits|nsubj|START_ENTITY elicits|dobj|+ +|compound|END_ENTITY	Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8 + and CD4 + T cell responses with broad antigen specificity .
22729530	0	NY-ESO-1	138,146	CD8	13,16	NY-ESO-1	CD8	246100	925	Gene	Gene	NY-ESO-1f|appos|START_ENTITY immunization|nmod|NY-ESO-1f restricted|nmod|immunization responses|acl|restricted responses|compound|END_ENTITY	Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f -LRB- NY-ESO-1 91-110 -RRB- peptide .
16951317	0	NY-ESO-1	54,62	calreticulin	23,35	NY-ESO-1	calreticulin	246100	811	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Dendritic cell surface calreticulin is a receptor for NY-ESO-1 : direct interactions between tumor-associated antigen and the innate immune system .
16540086	0	NY-REN-21	52,61	SCAND1	111,117	NY-REN-21	SCAND1	7589	51282	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1 .
20165904	0	NYGGF4	18,24	PID1	26,30	NYGGF4	PID1	55022	55022	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of NYGGF4 -LRB- PID1 -RRB- induces mitochondrial_impairment in 3T3-L1 adipocytes .
22160469	0	NYGGF4	8,14	insulin	18,25	NYGGF4	insulin	55022	3630	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|resistance resistance|compound|END_ENTITY	Role of NYGGF4 in insulin resistance .
25802485	0	NYX	0,3	CSNB1	64,69	NYX	CSNB1	60506	60506	Gene	Gene	mutations|nsubj|START_ENTITY mutations|nmod|END_ENTITY	NYX mutations in four families with high_myopia with or without CSNB1 .
12351189	0	NZF-2	44,49	MyT1	50,54	NZF-2	MyT1	17932(Tax:10090)	17932(Tax:10090)	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|dep|form	NZF-2b is a novel predominant form of mouse NZF-2 / MyT1 , expressed in differentiated neurons especially at higher levels in newly generated ones .
12169672	0	Na,K-ATPase	38,49	Phospholemman	0,13	Na,K-ATPase	Phospholemman	398583(Tax:8355)	444822(Tax:8355)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Phospholemman -LRB- FXYD1 -RRB- associates with Na,K-ATPase and regulates its transport properties .
7007696	0	Na-K	48,52	insulin	37,44	Na-K	insulin	29110	3630	Gene	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Apparent affinity changes induced by insulin of Na-K transport system in frog skeletal muscle .
10484329	0	Na-K-2Cl_cotransporter	57,79	JNK	0,3	Na-K-2Cl cotransporter	JNK	6558	5599	Gene	Gene	phosphorylates|dobj|START_ENTITY kinase|acl:relcl|phosphorylates kinase|nsubj|END_ENTITY	JNK is a volume-sensitive kinase that phosphorylates the Na-K-2Cl_cotransporter in vitro .
17595523	0	Na-K-2Cl_cotransporter	62,84	SPAK	39,43	Na-K-2Cl cotransporter	SPAK	100037166(Tax:8355)	446749(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	A single binding motif is required for SPAK activation of the Na-K-2Cl_cotransporter .
9199662	0	Na-K-Cl_co-transporter	40,62	NKCC1	64,69	Na-K-Cl co-transporter	NKCC1	6558	6558	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of the Na-K-Cl_co-transporter -LRB- NKCC1 -RRB- in the gerbil inner ear .
9727362	0	NaPi-2	52,58	NHE-3	21,26	NaPi-2	NHE-3	25548(Tax:10116)	24784(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states .
26506223	0	NaPi-IIb	50,58	SLC34A2	60,67	NaPi-IIb	SLC34A2	432056(Tax:8355)	20531(Tax:10090)	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|appos|END_ENTITY	Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb -LRB- SLC34A2 -RRB- by the Kinases SPAK and OSR1 .
26506223	0	NaPi-IIb	50,58	SPAK	84,88	NaPi-IIb	SPAK	432056(Tax:8355)	53416(Tax:10090)	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|nmod|END_ENTITY	Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb -LRB- SLC34A2 -RRB- by the Kinases SPAK and OSR1 .
21900231	0	Naa50p	23,29	N-terminal_acetyltransferase	41,69	Naa50p	N-terminal acetyltransferase	80218	80155	Gene	Gene	START_ENTITY|amod|complex complex|amod|END_ENTITY	Structure of a ternary Naa50p -LRB- NAT5/SAN -RRB- N-terminal_acetyltransferase complex reveals the molecular basis for substrate-specific acetylation .
9418898	0	Nab1	0,4	NGFI-A	23,29	Nab1	NGFI-A	4664	1958	Gene	Gene	START_ENTITY|appos|corepressor corepressor|nmod|END_ENTITY	Nab1 , a corepressor of NGFI-A -LRB- Egr-1 -RRB- , contains an active transcriptional repression domain .
22128144	0	Nab2	0,4	CD8	25,28	Nab2	CD8	4665	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	Nab2 regulates secondary CD8 + T-cell responses through control of TRAIL expression .
12220502	0	Naf1	28,32	ERK2	6,10	Naf1	ERK2	92345	5594	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	A new ERK2 binding protein , Naf1 , attenuates the EGF/ERK2 nuclear signaling .
7684270	0	Nak	54,57	GP_IV	40,45	Nak	GP IV	29110	51206	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Presence of the entire coding region of GP_IV mRNA in Nak -LRB- a -RRB- - negative platelets .
20661723	0	Nanog	77,82	Akt	30,33	Nanog	Akt	71950(Tax:10090)	11651(Tax:10090)	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	The phosphoinositide-3-kinase / Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells .
25146928	0	Nanog	15,20	BRD4	0,4	Nanog	BRD4	71950(Tax:10090)	57261(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	BRD4 regulates Nanog expression in mouse embryonic stem cells and preimplantation embryos .
26416882	0	Nanog	13,18	BRG1	0,4	Nanog	BRG1	71950(Tax:10090)	20586(Tax:10090)	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation .
17196549	0	Nanog	26,31	Beta-catenin	0,12	Nanog	Beta-catenin	71950(Tax:10090)	12387(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Beta-catenin up-regulates Nanog expression through interaction with Oct-3 / 4 in embryonic stem cells .
25377420	0	Nanog	29,34	Cited2	14,20	Nanog	Cited2	71950(Tax:10090)	17684(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells .
24793005	0	Nanog	20,25	ERK1	0,4	Nanog	ERK1	79923	5595	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal .
23040477	0	Nanog	18,23	Esrrb	0,5	Nanog	Esrrb	79923	2103	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells .
26296469	0	Nanog	26,31	GATA-1	0,6	Nanog	GATA-1	71950(Tax:10090)	14460(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GATA-1 directly regulates Nanog in mouse embryonic stem cells .
26296469	0	Nanog	26,31	GATA-1	0,6	Nanog	GATA-1	71950(Tax:10090)	14460(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GATA-1 directly regulates Nanog in mouse embryonic stem cells .
26190104	0	Nanog	19,24	Jarid2	0,6	Nanog	Jarid2	79923	3720	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development .
22696497	0	Nanog	52,57	N-cadherin	32,42	Nanog	N-cadherin	71950(Tax:10090)	12558(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	E-cadherin and , in its absence , N-cadherin promotes Nanog expression in mouse embryonic stem cells via STAT3 phosphorylation .
18687992	0	Nanog	17,22	Oct4	45,49	Nanog	Oct4	79923	5460	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Zfp143 regulates Nanog through modulation of Oct4 binding .
23649762	0	Nanog	35,40	Rbm47	20,25	Nanog	Rbm47	71950(Tax:10090)	245945(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells .
22696497	0	Nanog	52,57	STAT3	103,108	Nanog	STAT3	71950(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|phosphorylation phosphorylation|compound|END_ENTITY	E-cadherin and , in its absence , N-cadherin promotes Nanog expression in mouse embryonic stem cells via STAT3 phosphorylation .
26484184	0	Nanog	16,21	Snai1	0,5	Nanog	Snai1	79923	6615	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Snai1 represses Nanog to promote embryonic stem cell differentiation .
25003810	0	Nanog	16,21	Snail	0,5	Nanog	Snail	79923	6615	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3b signaling pathway in non-small-cell_lung_cancer .
21689689	0	Nanog	16,21	TRIM8	0,5	Nanog	TRIM8	79923	81603	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TRIM8 regulates Nanog via Hsp90b-mediated nuclear translocation of STAT3 in embryonic stem cells .
25445595	0	Nanog	0,5	Zfp57	27,32	Nanog	Zfp57	71950(Tax:10090)	22715(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nanog positively regulates Zfp57 expression in mouse embryonic_stem cells .
25175748	0	Nanog	24,29	androgen_receptor	61,78	Nanog	androgen receptor	79923	367	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	The pluripotency factor Nanog is directly upregulated by the androgen_receptor in prostate_cancer cells .
26636540	0	Nanog	37,42	miR-145	66,73	Nanog	miR-145	79923	406937	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|advcl|sponging sponging|xcomp|END_ENTITY	ROR functions as a ceRNA to regulate Nanog expression by sponging miR-145 and predicts poor prognosis in pancreatic_cancer .
15619621	0	Nanog	73,78	p53	0,3	Nanog	p53	71950(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression induces|advcl|suppressing induces|nsubj|END_ENTITY	p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression .
23651583	0	Nanog	57,62	p53	67,70	Nanog	p53	79923	7157	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells .
24333425	0	Nanog	28,33	p53	13,16	Nanog	p53	71950(Tax:10090)	22060(Tax:10090)	Gene	Gene	suppresses|xcomp|START_ENTITY suppresses|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of p53 suppresses Nanog expression in embryonic stem cells .
10559987	0	Nanos	36,41	Pumilio	9,16	Nanos	Pumilio	42297(Tax:7227)	41094(Tax:7227)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos .
11060247	0	Nanos	0,5	cup	21,24	Nanos	cup	42297(Tax:7227)	33934(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nanos interacts with cup in the female germline of Drosophila .
17047063	0	Nanos1	27,33	E-cadherin	0,10	Nanos1	E-cadherin	340719	999	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	E-cadherin regulates human Nanos1 , which interacts with p120ctn and induces tumor cell migration and invasion .
10767562	0	Nap1	6,10	NBP1	0,4	Nap1	NBP1	853922(Tax:4932)	851180(Tax:4932)	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|dep|protein	NBP1 -LRB- Nap1 binding protein 1 -RRB- , an essential gene for G2/M transition of Saccharomyces_cerevisiae , encodes a protein of distinct sub-nuclear localization .
24371087	0	Nap1	33,37	Protocadherin-18b	0,17	Nap1	Protocadherin-18b	561894(Tax:7955)	562031(Tax:7955)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish .
24798879	0	Nap1	0,4	RAD51	44,49	Nap1	RAD51	4673	5888	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1 .
13680156	0	Nap1p	46,51	Ats1p	25,30	Nap1p	Ats1p	853922(Tax:4932)	851213(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Saccharomyces_cerevisiae Ats1p interacts with Nap1p , a cytoplasmic protein that controls bud morphogenesis .
14678750	0	Narp	26,30	GluR1	88,93	Narp	GluR1	288475(Tax:10116)	50592(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	AGS-induced expression of Narp is concomitant with expression of AMPA receptor subunits GluR1 and GluR2 in hippocampus but not inferior_colliculus of P77PMC rats .
15018815	0	Nasal_embryonic_LHRH_factor	0,27	NELF	29,33	Nasal embryonic LHRH factor	NELF	26012	26012	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Nasal_embryonic_LHRH_factor -LRB- NELF -RRB- expression within the CNS and PNS of the rodent .
8170356	0	Nat-2	69,74	serotonin_N-acetyltransferase	29,58	Nat-2	serotonin N-acetyltransferase	17961(Tax:10090)	11298(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The locus controlling pineal serotonin_N-acetyltransferase activity -LRB- Nat-2 -RRB- is located on mouse chromosome 11 .
20550432	0	Nat2	23,27	N-acetyltransferase_2	0,21	Nat2	N-acetyltransferase 2	116632(Tax:10116)	116632(Tax:10116)	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	N-acetyltransferase_2 -LRB- Nat2 -RRB- polymorphism in the sand rat Psammomys obesus .
23493048	0	Natriuretic_peptide_receptor-3	0,30	NPR3	37,41	Natriuretic peptide receptor-3	NPR3	4883	4883	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Natriuretic_peptide_receptor-3 gene -LRB- NPR3 -RRB- : nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation .
25083114	0	Natural_Resistance-associated_Macrophage_Protein_1	28,78	NRAMP1	94,100	Natural Resistance-associated Macrophage Protein 1	NRAMP1	100737298	100737298	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Polymorphism , Expression of Natural_Resistance-associated_Macrophage_Protein_1 Encoding Gene -LRB- NRAMP1 -RRB- and Its Association with Immune Traits in Pigs .
21153198	0	Nb2	18,21	Lactogen	0,8	Nb2	Lactogen	53942	1443	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Lactogen enhances Nb2 cell GTPase activity after 4 hours incubation .
1406702	0	Nb2	4,7	prolactin_receptor	16,34	Nb2	prolactin receptor	114589(Tax:10116)	24684(Tax:10116)	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	The Nb2 form of prolactin_receptor is able to activate a milk protein gene promoter .
1718958	0	Nb2	40,43	prolactin_receptor	72,90	Nb2	prolactin receptor	114589(Tax:10116)	24684(Tax:10116)	Gene	Gene	line|appos|START_ENTITY expresses|nsubj|line expresses|dobj|form form|nmod|END_ENTITY	A prolactin-dependent immune cell line -LRB- Nb2 -RRB- expresses a mutant form of prolactin_receptor .
2394695	0	Nb2	87,90	prolactin_receptor	65,83	Nb2	prolactin receptor	114589(Tax:10116)	24684(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Mitogenic and binding properties of monoclonal antibodies to the prolactin_receptor in Nb2 rat lymphoma cells .
15965469	0	Nbs1	8,12	Atm	38,41	Nbs1	Atm	27354(Tax:10090)	11920(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models .
15734743	0	Nbs1	14,18	Mdm2	0,4	Nbs1	Mdm2	4683	4193	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair .
7910552	0	Ncam	46,50	Phox2	30,35	Ncam	Phox2	17967(Tax:10090)	11859(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype .
27033517	0	Nce102	21,27	Sng1	0,4	Nce102	Sng1	856272(Tax:4932)	853111(Tax:4932)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status .
10891396	0	Ncf1	109,113	p47-phox	99,107	Ncf1	p47-phox	17969(Tax:10090)	17969(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of the mouse p47-phox -LRB- Ncf1 -RRB- gene and comparative analysis of the mouse p47-phox -LRB- Ncf1 -RRB- gene to the human NCF1 gene .
10891396	0	Ncf1	50,54	p47-phox	40,48	Ncf1	p47-phox	17969(Tax:10090)	17969(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of the mouse p47-phox -LRB- Ncf1 -RRB- gene and comparative analysis of the mouse p47-phox -LRB- Ncf1 -RRB- gene to the human NCF1 gene .
15936744	0	Ncf1	0,4	p47phox	6,13	Ncf1	p47phox	114553(Tax:10116)	114553(Tax:10116)	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Ncf1 -LRB- p47phox -RRB- polymorphism determines oxidative burst and the severity of arthritis in rats and mice .
14559906	0	Nck	58,61	ERK	65,68	Nck	ERK	4690	5594	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion .
16595635	0	Nck	20,23	Fas_ligand	39,49	Nck	Fas ligand	4690	356	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The adaptor protein Nck interacts with Fas_ligand : Guiding the death factor to the cytotoxic immunological synapse .
16966330	0	Nck	70,73	Fyn	92,95	Nck	Fyn	4690	2534	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF .
8665484	0	Nck	47,50	Hepatocyte_growth_factor	0,24	Nck	Hepatocyte growth factor	4690	3082	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces activation of Nck and phospholipase C-gamma in lung_carcinoma cells .
27033705	0	Nck	64,67	Nephrin	0,7	Nck	Nephrin	17973(Tax:10090)	54631(Tax:10090)	Gene	Gene	Signaling|dep|START_ENTITY Signaling|compound|END_ENTITY	Nephrin Suppresses Hippo Signaling Through the Adaptor Proteins Nck and WTIP .
8798379	0	Nck	20,23	Pak1	89,93	Nck	Pak1	4690	5058	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1 .
10229072	0	Nck	15,18	SLP-76	48,54	Nck	SLP-76	4690	3937	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes .
15173187	0	Nck	49,52	SOCS3	24,29	Nck	SOCS3	17973(Tax:10090)	12702(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation .
9811447	0	Nck	50,53	eFGF	133,137	Nck	eFGF	399308(Tax:8355)	378586(Tax:8355)	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus .
18835251	0	Nck-1	0,5	PKR	21,24	Nck-1	PKR	4690	5610	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nck-1 interacts with PKR and modulates its activation by dsRNA .
21397687	0	Nck1	58,62	Dermcidin	18,27	Nck1	Dermcidin	4690	117159	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Dermcidin as a novel binding protein of Nck1 and characterization of its role in promoting cell migration .
22964333	0	Nck1	68,72	Max_binding_protein	18,37	Nck1	Max binding protein	4690	4335	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Max_binding_protein as a novel binding protein of Nck1 and characterization of its role in inhibiting human liver_cancer SK-HEP-1 cells .
20354146	0	NcoA4	55,60	nuclear_receptor_coactivator_4	23,53	NcoA4	nuclear receptor coactivator 4	27057(Tax:10090)	27057(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Variable expression of nuclear_receptor_coactivator_4 -LRB- NcoA4 -RRB- during mouse embryonic development .
23019124	0	Ncoa3	0,5	Esrrb	32,37	Ncoa3	Esrrb	8202	2103	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming .
22977234	0	Ncoa3	40,45	nuclear_receptor_coactivator_3	8,38	Ncoa3	nuclear receptor coactivator 3	17979(Tax:10090)	17979(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of nuclear_receptor_coactivator_3 -LRB- Ncoa3 -RRB- in pluripotency maintenance .
10446220	0	Ncx	42,45	Enx	47,50	Ncx	Enx	3196	21909(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	An enhancer element for expression of the Ncx -LRB- Enx , Hox11L1 -RRB- gene in neural crest-derived cells .
19836241	0	Ndc80	31,36	Dgt6	11,15	Ndc80	Dgt6	32316(Tax:7227)	43441(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Drosophila Dgt6 interacts with Ndc80 , Msps/XMAP215 , and gamma-tubulin to promote kinetochore-driven MT formation .
21832156	0	Ndc80	23,28	HEC1	46,50	Ndc80	HEC1	10403	10403	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Phosphorylation of the Ndc80 complex protein , HEC1 , by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint .
21283621	0	Ndel1	25,30	dynamin_2	41,50	Ndel1	dynamin 2	81565	1785	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The cytoskeletal protein Ndel1 regulates dynamin_2 GTPase activity .
19706893	0	Ndfip1	50,56	DMT1	30,34	Ndfip1	DMT1	80762	4891	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Divalent_metal_transporter_1 -LRB- DMT1 -RRB- regulation by Ndfip1 prevents metal toxicity in human neurons .
19706893	0	Ndfip1	50,56	Divalent_metal_transporter_1	0,28	Ndfip1	Divalent metal transporter 1	80762	4891	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Divalent_metal_transporter_1 -LRB- DMT1 -RRB- regulation by Ndfip1 prevents metal toxicity in human neurons .
22080920	0	Ndfip1	44,50	IL-4	62,66	Ndfip1	IL-4	65113(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	TGF-b induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation .
25632008	0	Ndfip1	0,6	Itch	17,21	Ndfip1	Itch	65113(Tax:10090)	16396(Tax:10090)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Activity Activity|compound|END_ENTITY	Ndfip1 Regulates Itch Ligase Activity and Airway Inflammation via UbcH7 .
22080920	0	Ndfip1	44,50	TGF-b	0,5	Ndfip1	TGF-b	65113(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation .
17137798	0	Ndfip1	0,6	itch	40,44	Ndfip1	itch	65113(Tax:10090)	16396(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY promotes|nsubj|protein promotes|ccomp|ligase ligase|nsubj|function function|nmod|ubiquitin ubiquitin|compound|END_ENTITY	Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation .
27048792	0	Ndfip2	0,6	DMT1	56,60	Ndfip2	DMT1	76273(Tax:10090)	18174(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver .
14985363	0	Ndrg2	51,56	Akt	0,3	Ndrg2	Akt	171114(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Akt mediates insulin-stimulated phosphorylation of Ndrg2 : evidence for cross-talk with protein_kinase_C theta .
24008097	0	Ndrg2	0,5	PGC-1a	11,17	Ndrg2	PGC-1a	29811(Tax:10090)	19017(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Ndrg2 is a PGC-1a / ERRa target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes .
18272787	0	Nebulin	0,7	CapZ	23,27	Nebulin	CapZ	374027(Tax:9031)	417771(Tax:9031)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc .
3678494	0	Nebulin	0,7	Duchenne_muscular_dystrophy	32,59	Nebulin	Duchenne muscular dystrophy	4703	1756	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Nebulin and titin expression in Duchenne_muscular_dystrophy appears normal .
23443021	0	Nebulin	0,7	NEB	9,12	Nebulin	NEB	4703	4703	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Nebulin -LRB- NEB -RRB- mutations in a childhood onset distal_myopathy with rods and cores uncovered by next generation sequencing .
24056153	0	Nebulin	60,67	NEB	69,72	Nebulin	NEB	4703	4703	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Nemaline_Myopathy_Type_2 -LRB- NEM2 -RRB- : Two Novel Mutations in the Nebulin -LRB- NEB -RRB- Gene .
17108174	0	Necdin	0,6	CDC2	21,25	Necdin	CDC2	17984(Tax:10090)	12534(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Necdin downregulates CDC2 expression to attenuate neuronal apoptosis .
11813259	0	Necdin	0,6	hnRNP_U	44,51	Necdin	hnRNP U	17984(Tax:10090)	51810(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Necdin interacts with the ribonucleoprotein hnRNP_U in the nuclear matrix .
23611113	0	Necl-4	15,21	CADM4	22,27	Necl-4	CADM4	199731	199731	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|END_ENTITY	Interaction of Necl-4 / CADM4 with ErbB3 and integrin a6 b4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly .
17558405	0	Necl4	19,24	SynCAM4	26,33	Necl4	SynCAM4	199731	199731	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A central role for Necl4 -LRB- SynCAM4 -RRB- in Schwann cell-axon interaction and myelination .
16036799	0	Nectin-1	0,8	HveC	9,13	Nectin-1	HveC	5818	5818	Gene	Gene	START_ENTITY|parataxis|Mediates Mediates|nsubj|END_ENTITY	Nectin-1 / HveC Mediates herpes_simplex_virus_type_1 entry into primary human sensory neurons and fibroblasts .
15564502	0	Nedd4	8,13	Gag	55,58	Nedd4	Gag	4734	1491923(Tax:11886)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Nedd4 and ubiquitination of Rous_sarcoma_virus Gag in budding of virus-like particles from cells .
18812566	0	Nedd4	0,5	IGF-1	43,48	Nedd4	IGF-1	17999(Tax:10090)	16000(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|END_ENTITY	Nedd4 controls animal growth by regulating IGF-1 signaling .
18287095	0	Nedd4	15,20	ISG15	0,5	Nedd4	ISG15	4734	9636	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response .
19125695	0	Nedd4	73,78	MTMR4	25,30	Nedd4	MTMR4	4734	9110	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4 .
17172638	0	Nedd4	29,34	Notch1	43,49	Nedd4	Notch1	25489(Tax:10116)	25496(Tax:10116)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced_muscle_tension .
18307411	0	Nedd4	93,98	PTEN	22,26	Nedd4	PTEN	4734	5728	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4 .
18353951	0	Nedd4	69,74	UL56	28,32	Nedd4	UL56	4734	1487345(Tax:10310)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Herpes_simplex_virus_type_2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination .
19835589	0	Nedd4	79,84	UL56	45,49	Nedd4	UL56	4734	1487345(Tax:10310)	Gene	Gene	relocalizes|dobj|START_ENTITY relocalizes|nsubj|END_ENTITY	Herpes_simplex_virus_type_2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions .
16931598	0	Nedd4	25,30	connexin43	40,50	Nedd4	connexin43	4734	2697	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process .
10446181	0	Nedd4	22,27	mGrb10	0,6	Nedd4	mGrb10	17999(Tax:10090)	14783(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	mGrb10 interacts with Nedd4 .
20519395	0	Nedd4-1	64,71	Alix	29,33	Nedd4-1	Alix	4734	10015	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif .
21765395	0	Nedd4-1	0,7	FGFR1	42,47	Nedd4-1	FGFR1	4734	2260	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function .
26556890	0	Nedd4-1	49,56	PDLIM7	0,6	Nedd4-1	PDLIM7	17999(Tax:10090)	67399(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle .
17715136	0	Nedd4-2	79,86	Akt	0,3	Nedd4-2	Akt	291553(Tax:10116)	24185(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2 .
22361880	0	Nedd4-2	80,87	CHT1	38,42	Nedd4-2	CHT1	23327	60482	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The high-affinity choline transporter CHT1 is regulated by the ubiquitin ligase Nedd4-2 .
20338996	0	Nedd4-2	72,79	Endothelin-1	0,12	Nedd4-2	Endothelin-1	23327	1906	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits the epithelial Na + channel through betaPix/14 -3 -3 / Nedd4-2 .
21900244	0	Nedd4-2	76,83	Neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2	0,74	Nedd4-2	Neural precursor cell-expressed developmentally down-regulated protein 4-2	23327	23327	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2 -LRB- Nedd4-2 -RRB- regulation by 14-3-3 protein binding at canonical serum_and_glucocorticoid_kinase_1 -LRB- SGK1 -RRB- phosphorylation sites .
26651153	0	Nedd4-2	21,28	Organic_Anion_Transporter-3	80,107	Nedd4-2	Organic Anion Transporter-3	291553(Tax:10116)	83500(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	An Essential Role of Nedd4-2 in the Ubiquitination , Expression , and Function of Organic_Anion_Transporter-3 .
22879586	0	Nedd4-2	136,143	caveolin-3	92,102	Nedd4-2	caveolin-3	23327	859	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Cell surface expression of human ether-a-go-go-related gene -LRB- hERG -RRB- channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2 .
22879586	0	Nedd4-2	136,143	hERG	61,65	Nedd4-2	hERG	23327	2078	Gene	Gene	protein|nmod|START_ENTITY regulated|nmod|protein regulated|nsubjpass|expression expression|nmod|channels channels|compound|END_ENTITY	Cell surface expression of human ether-a-go-go-related gene -LRB- hERG -RRB- channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2 .
23589291	0	Nedd4-2	116,123	hERG	71,75	Nedd4-2	hERG	23327	2078	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	The serum - _ and_glucocorticoid-inducible_kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11 .
23792956	0	Nedd4-2	166,173	hERG	52,56	Nedd4-2	hERG	23327	2078	Gene	Gene	neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2|appos|START_ENTITY channel|nmod|neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2 channel|nsubj|Regulation Regulation|dep|END_ENTITY	Regulation of the human ether-a-go-go-related gene -LRB- hERG -RRB- channel by Rab4 protein through neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2 -LRB- Nedd4-2 -RRB- .
24688054	0	Nedd4-2	109,116	hERG	41,45	Nedd4-2	hERG	23327	2078	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2 .
20504882	0	Nedd4-2	0,7	occludin	23,31	Nedd4-2	occludin	23327	100506658	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia .
19917253	0	Nedd4L	17,23	Smad2/3	42,49	Nedd4L	Smad2/3	83814(Tax:10090)	17126;17127	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Ubiquitin_ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling .
27086113	0	Nedd8	0,5	Smurf2	31,37	Nedd8	Smurf2	4738	64750	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation .
27086113	0	Nedd8	0,5	Smurf2	31,37	Nedd8	Smurf2	4738	64750	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation .
25452302	0	Nedd8	0,5	caspase-1	39,48	Nedd8	caspase-1	4738	834	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Nedd8 regulates inflammasome-dependent caspase-1 activation .
25170080	0	Nef	14,17	ATP-binding_Cassette_Transporter_A1	39,74	Nef	ATP-binding Cassette Transporter A1	6285	19	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	HIV-1 Protein Nef Inhibits Activity of ATP-binding_Cassette_Transporter_A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin .
25118280	0	Nef	21,24	Alix	55,59	Nef	Alix	156110(Tax:11676)	10015	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor .
10199403	0	Nef	55,58	CD4	12,15	Nef	CD4	6285	920	Gene	Gene	functions|compound|START_ENTITY motif|nmod|functions degradation|dep|motif degradation|compound|END_ENTITY	Nef-induced CD4 degradation : a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes .
10208934	0	Nef	6,9	CD4	66,69	Nef	CD4	6285	920	Gene	Gene	plays|nsubj|START_ENTITY plays|nmod|processes processes|nmod|down-regulation down-regulation|compound|END_ENTITY	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation : dissociation of the CD4-p56 -LRB- lck -RRB- complex and targeting of CD4 to lysosomes .
10375525	0	Nef	102,105	CD4	59,62	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein relieved|nmod|expression relieved|nsubjpass|Inhibition Inhibition|nmod|release release|nmod|END_ENTITY	Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein .
10375528	0	Nef	92,95	CD4	27,30	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	manner|amod|START_ENTITY incorporation|nmod|manner blocking|dobj|incorporation reduces|advcl|blocking reduces|nsubj|expression expression|nmod|END_ENTITY	Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef - and Vpu-inhibitable manner .
10477559	0	Nef	18,21	CD4	120,123	Nef	CD4	1490008(Tax:11723)	920	Gene	Gene	protein|compound|START_ENTITY utilizes|nsubj|protein utilizes|dobj|protein protein|acl|sorting sorting|nmod|down-regulation down-regulation|nmod|END_ENTITY	Cutting edge : SIV Nef protein utilizes both leucine - and tyrosine-based protein sorting pathways for down-regulation of CD4 .
10807905	0	Nef	59,62	CD4	76,79	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	START_ENTITY|amod|critical critical|nmod|down-regulation down-regulation|compound|END_ENTITY	The human thioesterase_II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation .
11086083	0	Nef	96,99	CD4	40,43	Nef	CD4	6285	920	Gene	Gene	role|nmod|START_ENTITY macrophages|dep|role mediated|nmod|macrophages mediated|nsubjpass|Resistance Resistance|nmod|apoptosis apoptosis|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Resistance to apoptosis in HIV-infected CD4 + T lymphocytes is mediated by macrophages : role for Nef and immune activation in viral persistence .
11264384	0	Nef	75,78	CD4	90,93	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	protein|compound|START_ENTITY protein|nmod|domain domain|compound|END_ENTITY	Direct in vitro binding of full-length human_immunodeficiency_virus_type_1 Nef protein to CD4 cytoplasmic domain .
11264386	0	Nef	91,94	CD4	12,15	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	sequence|nmod|START_ENTITY function|nsubj|sequence downregulation|parataxis|function downregulation|compound|END_ENTITY	Nef-induced CD4 downregulation : a diacidic sequence in human_immunodeficiency_virus_type_1 Nef does not function as a protein sorting motif through direct binding to beta-COP .
11581379	0	Nef	59,62	CD4	0,3	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	correlates|compound|START_ENTITY down-modulation|nmod|correlates depletion|amod|down-modulation depletion|nummod|END_ENTITY	CD4 down-modulation by human_immunodeficiency_virus_type_1 Nef correlates with the efficiency of viral replication and with CD4 -LRB- + -RRB- T-cell depletion in human lymphoid tissue ex vivo .
11907198	0	Nef	30,33	CD4	68,71	Nef	CD4	6285	920	Gene	Gene	delays|nsubj|START_ENTITY delays|dobj|progression progression|nmod|cells cells|compound|END_ENTITY	Simian_immunodeficiency_virus Nef protein delays the progression of CD4 + T cells through G1/S phase of the cell cycle .
11922627	0	Nef	78,81	CD4	29,32	Nef	CD4	6285	920	Gene	Gene	protein|compound|START_ENTITY binding|nmod|protein promotes|xcomp|binding promotes|nsubj|Presence Presence|nmod|helix helix|nmod|domain domain|compound|END_ENTITY	Presence of a helix in human CD4 cytoplasmic domain promotes binding to HIV-1 Nef protein .
11969293	0	Nef	6,9	CD4	85,88	Nef	CD4	6285	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|differentiation differentiation|dep|mechanism mechanism|nmod|T T|compound|END_ENTITY	HIV-1 Nef induces dendritic cell differentiation : a possible mechanism of uninfected CD4 -LRB- + -RRB- T cell activation .
12525647	0	Nef	87,90	CD4	67,70	Nef	CD4	6285	920	Gene	Gene	enhancement|compound|START_ENTITY correlates|nmod|enhancement correlates|nsubj|downregulation downregulation|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis .
13679604	0	Nef	119,122	CD4	48,51	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|motif motif|nmod|tail tail|nmod|END_ENTITY	The di-leucine motif in the cytoplasmic tail of CD4 is not required for binding to human_immunodeficiency_virus_type_1 Nef , but is critical for CD4 down-modulation .
14747534	0	Nef	36,39	CD4	97,100	Nef	CD4	6285	920	Gene	Gene	associates|compound|START_ENTITY rafts|nsubj|associates rafts|ccomp|downmodulate downmodulate|dobj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef associates with lipid rafts to downmodulate cell surface CD4 and class I major histocompatibility complex expression and to increase viral infectivity .
14990729	0	Nef	14,17	CD4	34,37	Nef	CD4	6285	920	Gene	Gene	protein|compound|START_ENTITY targets|nsubj|protein targets|dobj|cells cells|nummod|END_ENTITY	Extracellular Nef protein targets CD4 + T cells for apoptosis by interacting with CXCR4 surface receptors .
15133044	0	Nef	21,24	CD4	28,31	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts .
15166428	0	Nef	0,3	CD4	134,137	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	shows|nsubj|START_ENTITY shows|dobj|ability ability|nmod|END_ENTITY	Nef from a primary isolate of human_immunodeficiency_virus_type_1 lacking the EE -LRB- 155 -RRB- region shows decreased ability to down-regulate CD4 .
15258149	0	Nef	99,102	CD4	77,80	Nef	CD4	6285	920	Gene	Gene	products|compound|START_ENTITY requires|dobj|products requires|nsubj|Hyper-responsiveness Hyper-responsiveness|nmod|stimulation stimulation|nmod|cells cells|compound|END_ENTITY	Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4 + T cells requires Nef and Tat virus gene products and results from higher NFAT , NF-kappaB , and AP-1 induction .
15494497	0	Nef	39,42	CD4	0,3	Nef	CD4	6285	920	Gene	Gene	down-regulation|compound|START_ENTITY reverses|dobj|down-regulation reverses|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	CD4 phosphorylation partially reverses Nef down-regulation of CD4 .
15494497	0	Nef	39,42	CD4	62,65	Nef	CD4	6285	920	Gene	Gene	down-regulation|compound|START_ENTITY down-regulation|nmod|END_ENTITY	CD4 phosphorylation partially reverses Nef down-regulation of CD4 .
15611114	0	Nef	69,72	CD4	0,3	Nef	CD4	1490008(Tax:11723)	920	Gene	Gene	proteins|compound|START_ENTITY proteins|nummod|END_ENTITY	CD4 down-regulation by HIV-1 and simian_immunodeficiency_virus _ -LRB- SIV -RRB- Nef proteins involves both internalization and intracellular retention mechanisms .
16310238	0	Nef	6,9	CD4	49,52	Nef	CD4	57783(Tax:10090)	12504(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY mutations|acl|abrogating abrogating|dobj|downregulation downregulation|nmod|END_ENTITY	HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic_mice .
16310238	0	Nef	66,69	CD4	49,52	Nef	CD4	57783(Tax:10090)	12504(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY reduced|nsubj|functions affect|ccomp|reduced affect|nsubj|mutations mutations|acl|abrogating abrogating|dobj|downregulation downregulation|nmod|END_ENTITY	HIV-1 Nef mutations abrogating downregulation of CD4 affect other Nef functions and show reduced pathogenicity in transgenic_mice .
16979207	0	Nef	60,63	CD4	0,3	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	alleles|compound|START_ENTITY conserved|nmod|alleles conserved|nsubjpass|downregulation downregulation|compound|END_ENTITY	CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues , but Pak2 activation is highly variable .
17346169	0	Nef	40,43	CD4	14,17	Nef	CD4	6285	920	Gene	Gene	proteins|compound|START_ENTITY downregulation|nmod|proteins downregulation|nsubj|Mechanisms Mechanisms|nmod|END_ENTITY	Mechanisms of CD4 downregulation by the Nef and Vpu proteins of primate immunodeficiency viruses .
17411376	0	Nef	45,48	CD4	113,116	Nef	CD4	6285	920	Gene	Gene	protein|compound|START_ENTITY identified|nmod|protein peptides|acl|identified induce|nsubj|peptides induce|dobj|CD8 CD8|dep|+ +|compound|END_ENTITY	HLA-DR-restricted peptides identified in the Nef protein can induce HIV_type_1-specific IL-2 / IFN-gamma-secreting CD4 + and CD4 + / CD8 + T cells in humans after lipopeptide vaccination .
17600593	0	Nef	18,21	CD4	31,34	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Presence of HIV-1 Nef specific CD4 T cell response is associated with non-progression in HIV-1_infection .
17947540	0	Nef	121,124	CD4	47,50	Nef	CD4	6285	920	Gene	Gene	protein|compound|START_ENTITY functions|nmod|protein functions|nsubj|retention retention|nmod|END_ENTITY	Internalization and intracellular retention of CD4 are two separate functions of the human_immunodeficiency_virus_type_1 Nef protein .
18523251	0	Nef	49,52	CD4	83,86	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	site|nmod|START_ENTITY Lysine|appos|site required|nsubjpass|Lysine required|nmod|down-regulation down-regulation|compound|END_ENTITY	Lysine 144 , a ubiquitin attachment site in HIV-1 Nef , is required for Nef-mediated CD4 down-regulation .
19146681	0	Nef	22,25	CD4	80,83	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	START_ENTITY|nmod|enhancement enhancement|nmod|T T|compound|END_ENTITY	Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4 + T lymphocytes in human lymphoid tissue ex vivo .
19403684	0	Nef	36,39	CD4	56,59	Nef	CD4	6285	920	Gene	Gene	targets|compound|START_ENTITY END_ENTITY|nsubj|targets	Human_immunodeficiency_virus_type_1 Nef protein targets CD4 to the multivesicular body pathway .
19643141	0	Nef	59,62	CD4	27,30	Nef	CD4	6285	920	Gene	Gene	primary|compound|START_ENTITY downregulation|nmod|primary assessment|acl|downregulation assessment|nmod|END_ENTITY	Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection .
19740990	0	Nef	135,138	CD4	109,112	Nef	CD4	57783(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubjpass|activation activation|amod|Adult_AIDS-like_disease Adult_AIDS-like_disease|nmod|model model|dep|T-cell T-cell|compound|END_ENTITY	Adult_AIDS-like_disease in a novel inducible human_immunodeficiency_virus_type_1 Nef transgenic mouse model : CD4 + T-cell activation is Nef dependent and can occur in the absence_of_lymphophenia .
19740990	0	Nef	81,84	CD4	109,112	Nef	CD4	156110(Tax:11676)	12504(Tax:10090)	Gene	Gene	model|compound|START_ENTITY model|dep|T-cell T-cell|compound|END_ENTITY	Adult_AIDS-like_disease in a novel inducible human_immunodeficiency_virus_type_1 Nef transgenic mouse model : CD4 + T-cell activation is Nef dependent and can occur in the absence_of_lymphophenia .
20881088	0	Nef	62,65	CD4	0,3	Nef	CD4	6285	920	Gene	Gene	protein|compound|START_ENTITY downregulation|nmod|protein downregulation|nummod|END_ENTITY	CD4 downregulation by the human_immunodeficiency_virus_type_1 Nef protein is dispensable for optimal output and functionality of viral particles in primary T cells .
21543478	0	Nef	6,9	CD4	90,93	Nef	CD4	6285	920	Gene	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|trafficking trafficking|nmod|CD8 CD8|appos|END_ENTITY	HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I , CD4 , CD8 , and CD28 by distinct pathways that share common elements .
22103832	0	Nef	44,47	CD4	12,15	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activity activity|compound|END_ENTITY	Role of the CD4 down-modulation activity of Nef in HIV-1 infectivity .
22479639	0	Nef	6,9	CD4	65,68	Nef	CD4	6285	920	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|cells cells|compound|END_ENTITY	HIV-1 Nef enhances dendritic cell-mediated viral transmission to CD4 + T cells and promotes T-cell activation .
23151229	0	Nef	58,61	CD4	121,124	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	loop|compound|START_ENTITY Identification|nmod|loop Identification|acl|required required|nmod|downregulation downregulation|compound|END_ENTITY	Identification of a novel binding site between HIV_type_1 Nef C-terminal flexible loop and AP2 required for Nef-mediated CD4 downregulation .
24465014	0	Nef	4,7	CD4	55,58	Nef	CD4	6285	920	Gene	Gene	expression|compound|START_ENTITY favors|nsubj|expression favors|dobj|preservation preservation|nmod|cells cells|compound|END_ENTITY	HIV Nef expression favors the relative preservation of CD4 + T regulatory cells that retain some important suppressive functions .
24473078	0	Nef	10,13	CD4	64,67	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	hijacks|nsubj|START_ENTITY adaptor|csubj|hijacks adaptor|xcomp|downregulate downregulate|dobj|END_ENTITY	How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4 .
25118280	0	Nef	21,24	CD4	92,95	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	protein|compound|START_ENTITY Interaction|nmod|protein promotes|nsubj|Interaction promotes|dobj|lysosomal lysosomal|nmod|receptor receptor|compound|END_ENTITY	Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor .
25423108	0	Nef	0,3	CD4	45,48	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Neutralizes|nsubj|START_ENTITY Neutralizes|nmod|Cells Cells|compound|END_ENTITY	Nef Neutralizes the Ability of Exosomes from CD4 + T Cells to Act as Decoys during HIV-1_Infection .
7769669	0	Nef	122,125	CD4	20,23	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|downregulation downregulation|compound|END_ENTITY	Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human_immunodeficiency_virus_type_1 Nef .
7831289	0	Nef	36,39	CD4	109,112	Nef	CD4	6285	920	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|element element|nmod|tail tail|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail .
7871751	0	Nef	6,9	CD4	36,39	Nef	CD4	6285	920	Gene	Gene	downregulation|compound|START_ENTITY downregulation|nmod|expression expression|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
7871751	0	Nef	6,9	CD4	99,102	Nef	CD4	6285	920	Gene	Gene	downregulation|compound|START_ENTITY downregulation|dep|relevance relevance|nmod|domain domain|nmod|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
7902127	0	Nef	54,57	CD4	19,22	Nef	CD4	6285	920	Gene	Gene	expression|nmod|START_ENTITY molecules|nmod|expression molecules|nummod|END_ENTITY	Down-regulation of CD4 molecules by the expression of Nef : a quantitative analysis of CD4 antigens on the cell surfaces .
7902127	0	Nef	54,57	CD4	86,89	Nef	CD4	6285	920	Gene	Gene	expression|nmod|START_ENTITY molecules|nmod|expression Down-regulation|nmod|molecules Down-regulation|dep|analysis analysis|nmod|antigens antigens|nummod|END_ENTITY	Down-regulation of CD4 molecules by the expression of Nef : a quantitative analysis of CD4 antigens on the cell surfaces .
7903128	0	Nef	20,23	CD4	104,107	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	Nef 27 , but not the Nef 25 isoform of human_immunodeficiency_virus-type_1 pNL4 .3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells .
7905875	0	Nef	34,37	CD4	70,73	Nef	CD4	1490008(Tax:11723)	920	Gene	Gene	protein|compound|START_ENTITY promotes|nsubj|protein promotes|dobj|degradation degradation|nmod|END_ENTITY	The simian_immunodeficiency_virus Nef protein promotes degradation of CD4 in human T cells .
7917514	0	Nef	14,17	CD4	55,58	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression pathways|nsubj|Role pathways|nmod|cells cells|compound|END_ENTITY	Role of HIV-1 Nef expression in activation pathways in CD4 + T cells .
7983750	0	Nef	36,39	CD4	64,67	Nef	CD4	6285	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|accumulation accumulation|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef induces accumulation of CD4 in early endosomes .
8098729	0	Nef	79,82	CD4	31,34	Nef	CD4	1490008(Tax:11723)	920	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Downregulation of cell-surface CD4 expression by simian_immunodeficiency_virus Nef prevents viral_super_infection .
8102828	0	Nef	61,64	CD4	98,101	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	protein|compound|START_ENTITY protein|nmod|inhibitor inhibitor|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Evidence for the role of human_immunodeficiency_virus_type_1 Nef protein as a growth inhibitor to CD4 + T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies .
8124721	0	Nef	0,3	CD4	12,15	Nef	CD4	6285	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|endocytosis endocytosis|nummod|END_ENTITY	Nef induces CD4 endocytosis : requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain .
8124721	0	Nef	0,3	CD4	97,100	Nef	CD4	6285	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|endocytosis endocytosis|dep|requirement requirement|nmod|motif motif|nmod|domain domain|compound|END_ENTITY	Nef induces CD4 endocytosis : requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain .
8151774	0	Nef	129,132	CD4	26,29	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	sufficient|nmod|START_ENTITY sufficient|nsubj|domain domain|nmod|END_ENTITY	The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human_immunodeficiency_virus_type_1 Nef .
8184546	0	Nef	56,59	CD4	30,33	Nef	CD4	6285	920	Gene	Gene	surface|nmod|START_ENTITY surface|nsubj|suppression suppression|nmod|END_ENTITY	Specific suppression of human CD4 surface expression by Nef from the pathogenic simian_immunodeficiency_virus SIVmac239open .
8262036	0	Nef	41,44	CD4	0,3	Nef	CD4	156110(Tax:11676)	12504(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY downregulation|nmod|transgenic_mice downregulation|compound|END_ENTITY	CD4 cell surface downregulation in HIV-1 Nef transgenic_mice is a consequence of intracellular sequestration .
8265644	0	Nef	63,66	CD4	102,105	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	START_ENTITY|nmod|nucleus nucleus|nmod|cells cells|nmod|line line|compound|END_ENTITY	Highly localized tracks of human_immunodeficiency_virus_type_1 Nef in the nucleus of cells of a human CD4 + T-cell line .
8331733	0	Nef	0,3	CD4	84,87	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Nef from primary isolates of human immunodeficiency_virus type 1 suppresses surface CD4 expression in human and mouse T cells .
8437228	0	Nef	59,62	CD4	79,82	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The negative effect of human_immunodeficiency_virus_type_1 Nef on cell surface CD4 expression is not species specific and requires the cytoplasmic domain of CD4 .
8599214	0	Nef	29,32	CD4	99,102	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|identification identification|nmod|mutants mutants|acl:relcl|temperature-sensitive temperature-sensitive|nmod|downregulation downregulation|compound|END_ENTITY	Mutational analysis of HIV-1 Nef : identification of two mutants that are temperature-sensitive for CD4 downregulation .
8756680	0	Nef	48,51	CD4	4,7	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	downregulation|nmod|START_ENTITY determinant|nmod|downregulation determinant|compound|END_ENTITY	The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef .
8756680	0	Nef	70,73	CD4	4,7	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|determinant determinant|compound|END_ENTITY	The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef .
8804432	0	Nef	8,11	CD4	52,55	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	antigen|compound|START_ENTITY cytotoxic|nsubj|antigen cytotoxic|nmod|cells cells|compound|END_ENTITY	Soluble Nef antigen of HIV-1 is cytotoxic for human CD4 + T cells .
8804435	0	Nef	36,39	CD4	91,94	Nef	CD4	6285	920	Gene	Gene	protein|compound|START_ENTITY cytocidal|nsubj|protein cytocidal|nmod|cells cells|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef protein on the cell surface is cytocidal for human CD4 + T cells .
8871625	0	Nef	139,142	CD4	48,51	Nef	CD4	6285	920	Gene	Gene	overlapping|nmod|START_ENTITY analysis|dep|overlapping analysis|nmod|domain domain|nmod|END_ENTITY	Molecular analysis of the cytoplasmic domain of CD4 : overlapping but noncompetitive requirement for lck association and down-regulation by Nef .
9032396	0	Nef	68,71	CD4	91,94	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of phosphorylation of human_immunodeficiency_virus_type_1 Nef and enhancement of CD4 downregulation by phorbol_myristate_acetate .
9049297	0	Nef	23,26	CD4	77,80	Nef	CD4	6285	920	Gene	Gene	functions|nmod|START_ENTITY disrupt|nsubj|functions disrupt|dobj|aspects aspects|nmod|machinery machinery|dep|expression expression|compound|END_ENTITY	Separable functions of Nef disrupt two aspects of T cell receptor machinery : CD4 expression and CD3 signaling .
9153233	0	Nef	17,20	CD4	81,84	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Binding|nmod|START_ENTITY thioesterase|nsubj|Binding thioesterase|nmod|down-regulation down-regulation|compound|END_ENTITY	Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation .
9168885	0	Nef	35,38	CD4	93,96	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	regions|nmod|START_ENTITY Identification|nmod|regions required|nsubj|Identification required|nmod|downregulation downregulation|nmod|END_ENTITY	Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4 .
9384576	0	Nef	25,28	CD4	95,98	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Co-localization|nmod|START_ENTITY correlates|nsubj|Co-localization correlates|nmod|down-regulation down-regulation|compound|END_ENTITY	Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation .
9473011	0	Nef	64,67	CD4	79,82	Nef	CD4	6285	920	Gene	Gene	contain|dobj|START_ENTITY contain|advcl|promote promote|dobj|downmodulation downmodulation|compound|END_ENTITY	T cells chronically infected with HIV do not contain sufficient Nef to promote CD4 downmodulation in the absence of envelope-mediated effects .
9564030	0	Nef	42,45	CD4	25,28	Nef	CD4	6285	920	Gene	Gene	CD4|compound|START_ENTITY Mechanism|dep|CD4 Mechanism|nmod|endocytosis endocytosis|compound|END_ENTITY	Mechanism of Nef-induced CD4 endocytosis : Nef connects CD4 with the mu chain of adaptor complexes .
9620685	0	Nef	26,29	CD4	84,87	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Interactions|nmod|START_ENTITY facilitate|nsubj|Interactions facilitate|dobj|internalization internalization|nmod|END_ENTITY	Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4 .
9736718	0	Nef	21,24	CD4	91,94	Nef	CD4	156110(Tax:11676)	920	Gene	Gene	Interaction|nmod|START_ENTITY required|nsubjpass|Interaction required|nmod|down-regulation down-regulation|nummod|END_ENTITY	Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity .
9920849	0	Nef	36,39	CD4	59,62	Nef	CD4	6285	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef protein sensitizes CD4 -LRB- + -RRB- T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 _ ligand pathway .
9971776	0	Nef	169,172	CD4	12,15	Nef	CD4	6285	920	Gene	Gene	repeat|nmod|START_ENTITY regulate|nsubj|repeat alpha|ccomp|regulate governed|parataxis|alpha governed|nsubjpass|END_ENTITY	Nef-induced CD4 and major histocompatibility complex class I -LRB- MHC-I -RRB- down-regulation are governed by distinct determinants : N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking .
16904156	0	Nef	26,29	CD8	41,44	Nef	CD8	6285	925	Gene	Gene	protein|compound|START_ENTITY protein|nmod|cells cells|compound|END_ENTITY	Poor recognition of HIV-1 Nef protein by CD8 T cells from HIV-1-infected children : impact of age .
22753736	0	Nef	16,19	CXCR4	62,67	Nef	CXCR4	6285	7852	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	SIVmac - Nef down-regulates cell surface expression of CXCR4 in tumor cells and inhibits proliferation , migration and angiogenesis .
25170080	0	Nef	14,17	Calnexin	120,128	Nef	Calnexin	6285	821	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	HIV-1 Protein Nef Inhibits Activity of ATP-binding_Cassette_Transporter_A1 by Targeting Endoplasmic Reticulum Chaperone Calnexin .
17412836	0	Nef	66,69	Dynamin_2	0,9	Nef	Dynamin 2	156110(Tax:11676)	1785	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Dynamin_2 is required for the enhancement of HIV-1 infectivity by Nef .
16043695	0	Nef	6,9	HFE	53,56	Nef	HFE	6285	3077	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	HIV-1 Nef down-regulates the hemochromatosis protein HFE , manipulating cellular iron homeostasis .
26787826	0	Nef	76,79	HLA-B	23,28	Nef	HLA-B	156110(Tax:11676)	3106	Gene	Gene	Sequences|compound|START_ENTITY END_ENTITY|nmod|Sequences	Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences .
12033791	0	Nef	80,83	Hck	24,27	Nef	Hck	6285	3055	Gene	Gene	protein|compound|START_ENTITY evolution|nmod|protein reveals|dobj|evolution reveals|nsubj|Interaction Interaction|nmod|kinase kinase|compound|END_ENTITY	Interaction with simian Hck tyrosine kinase reveals convergent evolution of the Nef protein from simian and human immunodeficiency viruses despite differential molecular surface usage .
12076760	0	Nef	82,85	Hck	119,122	Nef	Hck	6285	3055	Gene	Gene	interaction|nmod|START_ENTITY inhibitors|nmod|interaction system|nmod|inhibitors kinase|nsubj|system kinase|dobj|END_ENTITY	A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck .
15491611	0	Nef	32,35	Hck	107,110	Nef	Hck	156110(Tax:11676)	25734(Tax:10116)	Gene	Gene	pocket|compound|START_ENTITY residues|nmod|pocket essential|nsubj|residues essential|nmod|recruitment recruitment|nmod|kinase kinase|compound|END_ENTITY	Conserved residues in the HIV-1 Nef hydrophobic pocket are essential for recruitment and activation of the Hck tyrosine kinase .
15626739	0	Nef	6,9	Hck	59,62	Nef	Hck	6285	3055	Gene	Gene	interferes|nsubj|START_ENTITY interferes|xcomp|signaling signaling|nmod|activation activation|compound|END_ENTITY	HIV-1 Nef interferes with M-CSF receptor signaling through Hck activation and inhibits M-CSF bioactivities .
16849330	0	Nef	6,9	Hck	51,54	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	activates|nsubj|START_ENTITY activates|ccomp|kinases kinases|dobj|END_ENTITY	HIV-1 Nef selectively activates Src family kinases Hck , Lyn , and c-Src through direct SH3 domain interaction .
21365684	0	Nef	62,65	Hck	25,28	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Structure , dynamics , and Hck interaction of full-length HIV-1 Nef .
21567396	0	Nef	6,9	Hck	94,97	Nef	Hck	6285	3055	Gene	Gene	perturbs|nsubj|START_ENTITY perturbs|nmod|END_ENTITY	HIV-1 Nef perturbs the function , structure , and signaling of the Golgi through the Src kinase Hck .
22420777	0	Nef	6,9	Hck	80,83	Nef	Hck	6285	3055	Gene	Gene	interaction|compound|START_ENTITY influences|nsubj|interaction influences|dobj|site site|nmod|kinase kinase|appos|END_ENTITY	HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase , Hck .
25122770	0	Nef	101,104	Hck	76,79	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	Dimer|compound|START_ENTITY Structures|dobj|Dimer Structures|nsubj|Interaction Interaction|nmod|Region Region|nmod|END_ENTITY	Interaction with the Src Homology -LRB- SH3-SH2 -RRB- Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment .
26440750	0	Nef	57,60	Hck	33,36	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor .
26584215	0	Nef	144,147	Hck	25,28	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|kinase kinase|appos|END_ENTITY	Hemopoietic cell kinase -LRB- Hck -RRB- and p21-activated_kinase_2 -LRB- PAK2 -RRB- are involved in the down-regulation of CD1a lipid antigen presentation by HIV-1 Nef in dendritic cells .
7588629	0	Nef	110,113	Hck	41,44	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	binding|nmod|START_ENTITY protein|amod|binding affinity|nmod|protein determines|dobj|affinity determines|nsubj|amino_acid amino_acid|nmod|domain domain|nmod|END_ENTITY	A single amino_acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein .
8599760	0	Nef	32,35	Hck	132,135	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	structure|nmod|START_ENTITY reveals|nsubj|structure reveals|dobj|fold fold|nmod|surface surface|nmod|domain domain|nmod|kinase kinase|compound|END_ENTITY	The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase .
9218412	0	Nef	81,84	Hck	13,16	Nef	Hck	156110(Tax:11676)	3055	Gene	Gene	protein|compound|START_ENTITY activation|nmod|protein tyrosine|dobj|activation tyrosine|nsubj|END_ENTITY	SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1 .
20056088	0	Nef	7,10	ICAM-1	21,27	Nef	ICAM-1	156110(Tax:11676)	3383	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	-LSB- HIV-1 Nef regulates ICAM-1 expression on endothelial cells via Erk / Mapk signaling pathway -RSB- .
10544125	0	Nef	58,61	Lck	96,99	Nef	Lck	156110(Tax:11676)	3932	Gene	Gene	core|nmod|START_ENTITY essential|nsubj|core essential|nmod|association association|nmod|END_ENTITY	The conserved core of human_immunodeficiency_virus_type_1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes .
15976924	0	Nef	46,49	Lck	59,62	Nef	Lck	156110(Tax:11676)	3932	Gene	Gene	site|nmod|START_ENTITY Mapping|dobj|site Mapping|nmod|SH3 SH3|compound|END_ENTITY	Mapping the binding site of full length HIV-1 Nef on human Lck SH3 by NMR spectroscopy .
18030346	0	Nef	6,9	Lck	54,57	Nef	Lck	6285	3932	Gene	Gene	employs|nsubj|START_ENTITY employs|nmod|localization localization|compound|END_ENTITY	HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling .
19050260	0	Nef	34,37	Lck	47,50	Nef	Lck	6285	3932	Gene	Gene	transcription|nmod|START_ENTITY Induction|nmod|transcription involves|nsubj|Induction involves|dobj|activation activation|compound|END_ENTITY	Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B .
8626429	0	Nef	39,42	Lck	48,51	Nef	Lck	6285	3932	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of Nef with Lck .
8794306	0	Nef	36,39	Lck	58,61	Nef	Lck	6285	3932	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef binds directly to Lck and mitogen-activated protein kinase , inhibiting kinase activity .
9075929	0	Nef	18,21	Lck	82,85	Nef	Lck	156110(Tax:11676)	3932	Gene	Gene	N-terminus|nmod|START_ENTITY associates|dep|N-terminus associates|nmod|complex complex|acl|containing containing|dobj|END_ENTITY	The N-terminus of Nef from HIV-1 / SIV associates with a protein complex containing Lck and a serine kinase .
9705913	0	Nef	40,43	Lck	90,93	Nef	Lck	156110(Tax:11676)	3932	Gene	Gene	protein|compound|START_ENTITY binds|nsubj|protein binds|dobj|domain domain|compound|END_ENTITY	The human_immunodeficiency_virus_type_1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism .
21449607	0	Nef	17,20	N-myristoyltransferase_1	30,54	Nef	N-myristoyltransferase 1	156110(Tax:11676)	4836	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of HIV-1 Nef on human N-myristoyltransferase_1 .
19019824	0	Nef	6,9	NFkappaB	94,102	Nef	NFkappaB	6285	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|inhibiting inhibiting|dobj|END_ENTITY	HIV-1 Nef inhibits lipopolysaccharide-induced IL-12p40 expression by inhibiting JNK-activated NFkappaB in human monocytic cells .
9490697	0	Nef	111,114	Nef	51,54	Nef	Nef	6285	156110(Tax:11676)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Adenovirus-mediated human_immunodeficiency_virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines .
9490697	0	Nef	51,54	Nef	111,114	Nef	Nef	156110(Tax:11676)	6285	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Adenovirus-mediated human_immunodeficiency_virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines .
18296443	0	Nef	6,9	PACS-2	16,22	Nef	PACS-2	57783(Tax:10090)	217893(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I -LRB- MHC-I -RRB- down-regulation : analysis using short interfering RNA and knock-out mice .
11160719	0	Nef	36,39	PAK2	132,136	Nef	PAK2	6285	5062	Gene	Gene	selectively|nsubj|START_ENTITY selectively|nmod|subpopulation subpopulation|nmod|independently independently|appos|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef selectively associates with a catalytically active subpopulation of p21-activated_kinase_2 -LRB- PAK2 -RRB- independently of PAK2 binding to Nck or beta-PIX .
11160719	0	Nef	36,39	PAK2	155,159	Nef	PAK2	6285	5062	Gene	Gene	selectively|nsubj|START_ENTITY selectively|nmod|subpopulation subpopulation|nmod|independently independently|nmod|binding binding|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef selectively associates with a catalytically active subpopulation of p21-activated_kinase_2 -LRB- PAK2 -RRB- independently of PAK2 binding to Nck or beta-PIX .
16272310	0	Nef	34,37	PAK2	57,61	Nef	PAK2	156110(Tax:11676)	5062	Gene	Gene	analysis|nmod|START_ENTITY reveals|nsubj|analysis reveals|nmod|END_ENTITY	Functional analysis of HIV_type_1 Nef reveals a role for PAK2 as a regulator of cell phenotype and function in the murine dendritic cell line , DC2 .4 .
26350970	0	Nef	68,71	PAK2	17,21	Nef	PAK2	6285	5062	Gene	Gene	Proteins|compound|START_ENTITY Association|nmod|Proteins Association|nmod|Interactions Interactions|compound|END_ENTITY	Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex .
11070003	0	Nef	11,14	Pak2	38,42	Nef	Pak2	6285	5062	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Lentivirus Nef specifically activates Pak2 .
11312657	0	Nef	18,21	Rack1	0,5	Nef	Rack1	156110(Tax:11676)	10399	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor .
11675348	0	Nef	6,9	STAT1	20,25	Nef	STAT1	6285	6772	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors .
12396456	0	Nef	36,39	STAT3	63,68	Nef	STAT3	6285	6774	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef mediates activation of STAT3 in immature dendritic cells .
12960275	0	Nef	157,160	STAT3	58,63	Nef	STAT3	156110(Tax:11676)	6774	Gene	Gene	involvement|nmod|START_ENTITY domains|nsubj|involvement activates|parataxis|domains activates|dobj|END_ENTITY	Human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors : involvement of Nef domains interacting with the cell endocytotic machinery .
12960275	0	Nef	44,47	STAT3	58,63	Nef	STAT3	6285	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors : involvement of Nef domains interacting with the cell endocytotic machinery .
10642173	0	Nef	50,53	Src	12,15	Nef	Src	6285	20779(Tax:10090)	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo .
15343382	0	Nef	0,3	Stat3	89,94	Nef	Stat3	6285	6774	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1 ,2 pathways .
18094167	0	Nef	36,39	Vav1	77,81	Nef	Vav1	6285	7409	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated_kinase_2 activity .
24130899	0	Nef	6,9	b-catenin	25,34	Nef	b-catenin	6285	1499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	HIV 's Nef interacts with b-catenin of the Wnt signaling pathway in HEK293 cells .
7982906	0	Nef	34,37	beta-COP	51,59	Nef	beta-COP	156110(Tax:11676)	9276	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Physical interaction of the HIV-1 Nef protein with beta-COP , a component of non-clathrin-coated vesicles essential for membrane traffic .
10196292	0	Nef	0,3	interleukin-2	76,89	Nef	interleukin-2	6285	3558	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo .
7871751	0	Nef	6,9	lck	77,80	Nef	lck	6285	3932	Gene	Gene	downregulation|compound|START_ENTITY downregulation|dep|relevance relevance|nmod|domain domain|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
8871625	0	Nef	139,142	lck	100,103	Nef	lck	6285	3932	Gene	Gene	overlapping|nmod|START_ENTITY overlapping|nmod|association association|compound|END_ENTITY	Molecular analysis of the cytoplasmic domain of CD4 : overlapping but noncompetitive requirement for lck association and down-regulation by Nef .
19130504	0	Nef	6,9	p47	18,21	Nef	p47	6285	5341	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	HIV-1 Nef induces p47 -LRB- phox -RRB- phosphorylation leading to a rapid superoxide anion release from the U937 human monoblastic cell line .
11861836	0	Nef	36,39	p53	66,69	Nef	p53	6285	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis .
18799583	0	Nef	36,39	programmed_death_1	48,66	Nef	programmed death 1	6285	5133	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef induces programmed_death_1 expression through a p38 mitogen-activated protein kinase-dependent mechanism .
11000208	0	Nef	36,39	tumor_necrosis_factor	82,103	Nef	tumor necrosis factor	6285	7124	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef mediates sustained membrane expression of tumor_necrosis_factor and the related cytokine LIGHT on activated T cells .
15297702	0	Nefl	21,25	lens_rupture_2	75,89	Nefl	lens rupture 2	18039(Tax:10090)	68813(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Fine localization of Nefl and Nef3 and its exclusion as candidate gene for lens_rupture_2 -LRB- lr2 -RRB- .
15742362	0	Nefl	61,65	neurofilament_of_low-molecular-weight	22,59	Nefl	neurofilament of low-molecular-weight	18039(Tax:10090)	18039(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mice with the deleted neurofilament_of_low-molecular-weight -LRB- Nefl -RRB- gene : 1 .
16581765	0	Neh2	15,19	Keap1	0,5	Neh2	Keap1	252969	9817	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Keap1 recruits Neh2 through binding to ETGE and DLG motifs : characterization of the two-site molecular recognition model .
15339932	0	Nei-like-2	59,69	NEIL2	52,57	Nei-like-2	NEIL2	252969	252969	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of a zinc finger domain in the human NEIL2 -LRB- Nei-like-2 -RRB- protein .
23851348	0	Nek1	0,4	Ku80	20,24	Nek1	Ku80	4750	7520	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression .
15161910	0	Nek11	10,15	Nek2A	37,42	Nek11	Nek2A	79858	4751	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells .
25704143	0	Nek2	26,30	Cep68	0,5	Nek2	Cep68	4751	23177	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cep68 can be regulated by Nek2 and SCF complex .
12386167	0	Nek2	57,61	Hec1	49,53	Nek2	Hec1	4751	10403	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation .
26290419	0	Nek2	0,4	Kif24	19,24	Nek2	Kif24	4751	347240	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle .
26290419	0	Nek2	0,4	Kif24	19,24	Nek2	Kif24	4751	347240	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle .
15161910	0	Nek2A	37,42	Nek11	10,15	Nek2A	Nek11	4751	79858	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells .
25940345	0	Nek6	44,48	Hsp72	0,5	Nek6	Hsp72	10783	3303	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression .
21454704	0	Nek6	100,104	Nek9	116,120	Nek6	Nek9	10783	91754	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9 .
22899815	0	Nek8	117,121	RCC1	102,106	Nek8	RCC1	287473(Tax:10116)	682908(Tax:10116)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	A novel mutation causing nephronophthisis in the Lewis_polycystic_kidney rat localises to a conserved RCC1 domain in Nek8 .
21454704	0	Nek9	116,120	Nek6	100,104	Nek9	Nek6	91754	10783	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9 .
24563467	0	Nel-like_molecule_1	74,93	NELL1	95,100	Nel-like molecule 1	NELL1	338352(Tax:10090)	338352(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Oligomerization-induced conformational change in the C-terminal region of Nel-like_molecule_1 -LRB- NELL1 -RRB- protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading .
21611965	0	Nell-1	37,43	Nfatc2	0,6	Nell-1	Nfatc2	338352(Tax:10090)	18019(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells .
20939017	0	Nell-1	0,6	Runx2	37,42	Nell-1	Runx2	338352(Tax:10090)	12393(Tax:10090)	Gene	Gene	START_ENTITY|appos|mediator mediator|nmod|END_ENTITY	Nell-1 , a key functional mediator of Runx2 , partially rescues calvarial_defects in Runx2 -LRB- + / - -RRB- mice .
20939017	0	Nell-1	0,6	Runx2	83,88	Nell-1	Runx2	338352(Tax:10090)	12393(Tax:10090)	Gene	Gene	rescues|nsubj|START_ENTITY rescues|dobj|calvarial_defects calvarial_defects|nmod|mice mice|amod|END_ENTITY	Nell-1 , a key functional mediator of Runx2 , partially rescues calvarial_defects in Runx2 -LRB- + / - -RRB- mice .
22496866	0	Nell2	30,35	Macf1	51,56	Nell2	Macf1	81734(Tax:10116)	362587(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The neuronal EGF-related gene Nell2 interacts with Macf1 and supports survival of retinal ganglion cells after optic_nerve_injury .
20116374	0	Nemo-like_kinase	0,16	NLK	18,21	Nemo-like kinase	NLK	18099(Tax:10090)	18099(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Nemo-like_kinase -LRB- NLK -RRB- expression in osteoblastic cells and suppression of osteoblastic differentiation .
23325309	0	Nemo-like_kinase	14,30	NLK	32,35	Nemo-like kinase	NLK	497961(Tax:10116)	497961(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Nemo-like_kinase -LRB- NLK -RRB- in the brain in a rat experimental subarachnoid_hemorrhage model .
27036119	0	Nemo-like_kinase	0,16	Nurr1	61,66	Nemo-like kinase	Nurr1	51701	4929	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Nemo-like_kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate_cancer .
23719801	0	Nemo-like_kinase	47,63	spinocerebellar_ataxia_type_1	67,96	Nemo-like kinase	spinocerebellar ataxia type 1	18099(Tax:10090)	20238(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Polyglutamine disease toxicity is regulated by Nemo-like_kinase in spinocerebellar_ataxia_type_1 .
27035511	0	Nemo-like_kinase	0,16	vascular_endothelial_growth_factor	45,79	Nemo-like kinase	vascular endothelial growth factor	18099(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Nemo-like_kinase regulates the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in alveolar epithelial cells .
20065295	0	Neogenin	0,8	HJV	18,21	Neogenin	HJV	18007(Tax:10090)	69585(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis .
16836993	0	Neogenin	0,8	RGMa	24,28	Neogenin	RGMa	100381051(Tax:8355)	380244(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain .
22275192	0	Neogenin	0,8	Sonic_Hedgehog	19,33	Neogenin	Sonic Hedgehog	18007(Tax:10090)	20423(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Neogenin regulates Sonic_Hedgehog pathway activity during digit patterning .
26260795	0	Neonatal_Fc_Receptor	21,41	FcRn	43,47	Neonatal Fc Receptor	FcRn	2217	2217	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Critical Role of the Neonatal_Fc_Receptor -LRB- FcRn -RRB- in the Pathogenic Action of Antimitochondrial Autoantibodies Synergizing with Anti-desmoglein Autoantibodies in Pemphigus_Vulgaris .
17923684	0	Neph1	0,5	nephrin	22,29	Neph1	nephrin	55243	4868	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization .
15086927	0	Nephrin	0,7	NPHS1	14,19	Nephrin	NPHS1	4868	4868	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Nephrin gene -LRB- NPHS1 -RRB- in patients with minimal change nephrotic_syndrome -LRB- MCNS -RRB- .
27033705	0	Nephrin	0,7	Nck	64,67	Nephrin	Nck	54631(Tax:10090)	17973(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|dep|END_ENTITY	Nephrin Suppresses Hippo Signaling Through the Adaptor Proteins Nck and WTIP .
25012178	0	Nephrin	116,123	Vascular_Endothelial_Growth_Factor	17,51	Nephrin	Vascular Endothelial Growth Factor	4868	7422	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	GIV/Girdin Links Vascular_Endothelial_Growth_Factor Signaling to Akt Survival Signaling in Podocytes Independent of Nephrin .
15345329	0	Nephroblastoma_overexpressed_gene	0,33	NOV	35,38	Nephroblastoma overexpressed gene	NOV	81526(Tax:10116)	81526(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nephroblastoma_overexpressed_gene -LRB- NOV -RRB- expression in rat hepatic stellate cells .
18477472	0	Nephrocystin-1	0,14	Ack1	39,43	Nephrocystin-1	Ack1	4867	10188	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct .
12106348	0	Nerve_Growth_Factor	27,46	NGF	48,51	Nerve Growth Factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Differential Regulation of Nerve_Growth_Factor -LRB- NGF -RRB- Synthesis in Neurons and Astrocytes by Glucocorticoid Hormones .
26041925	0	Nerve_Growth_Factor	36,55	TRPV1	77,82	Nerve Growth Factor	TRPV1	4803	7442	Gene	Gene	Triggered|nmod|START_ENTITY Mediated|nsubjpass|Triggered Mediated|nmod|Mechanisms Mechanisms|compound|END_ENTITY	Persistent Nociception Triggered by Nerve_Growth_Factor -LRB- NGF -RRB- Is Mediated by TRPV1 and Oxidative Mechanisms .
26668319	0	Nerve_Growth_Factor	0,19	Toll-Like_Receptor_2	36,56	Nerve Growth Factor	Toll-Like Receptor 2	4803	7097	Gene	Gene	Regulated|nsubjpass|START_ENTITY Regulated|nmod|END_ENTITY	Nerve_Growth_Factor is Regulated by Toll-Like_Receptor_2 in Human Intervertebral Discs .
17213958	0	Nerve_growth_factor	0,19	Akt	144,147	Nerve growth factor	Akt	310738(Tax:10116)	24185(Tax:10116)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|advcl|activating activating|dobj|END_ENTITY	Nerve_growth_factor prevents the apoptosis-associated increase in acetylcholinesterase activity after hydrogen_peroxide treatment by activating Akt .
8612710	0	Nerve_growth_factor	0,19	BCL-2	93,98	Nerve growth factor	BCL-2	4803	596	Gene	Gene	rescues|nsubj|START_ENTITY rescues|advcl|upregulating upregulating|dobj|levels levels|compound|END_ENTITY	Nerve_growth_factor rescues pigment cells from ultraviolet-induced apoptosis by upregulating BCL-2 levels .
12388545	0	Nerve_growth_factor	0,19	Bcl-2	45,50	Nerve growth factor	Bcl-2	310738(Tax:10116)	24224(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|Bim Bim|amod|END_ENTITY	Nerve_growth_factor -LRB- NGF -RRB- down-regulates the Bcl-2 homology 3 -LRB- BH3 -RRB- domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation .
11544458	0	Nerve_growth_factor	0,19	IL-13	41,46	Nerve growth factor	IL-13	4803	3596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Nerve_growth_factor or IL-3 induces more IL-13 production from basophils of allergic subjects than from basophils of nonallergic subjects .
11502362	0	Nerve_growth_factor	0,19	Isl-1	87,92	Nerve growth factor	Isl-1	310738(Tax:10116)	64444(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nerve_growth_factor induces the expression of the LIM homeodomain transcription factor Isl-1 with the kinetics of an immediate early gene in adult rat dorsal root ganglion .
10606727	0	Nerve_growth_factor	0,19	MAPK	31,35	Nerve growth factor	MAPK	310738(Tax:10116)	50689(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Nerve_growth_factor stimulates MAPK via the low affinity receptor p75 -LRB- LNTR -RRB- .
15554384	0	Nerve_growth_factor	0,19	MMP-2	31,36	Nerve growth factor	MMP-2	4803	4313	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Nerve_growth_factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic_cancer cells .
9291146	0	Nerve_growth_factor	0,19	NGF	21,24	Nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nerve_growth_factor -LRB- NGF -RRB- expression in rat microglia is induced by adenosine_A2a-receptors .
21975456	0	Nerve_growth_factor	0,19	PKM	130,133	Nerve growth factor	PKM	310738(Tax:10116)	25630(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Nerve_growth_factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform , PKM .
11404390	0	Nerve_growth_factor	0,19	TNF-alpha	30,39	Nerve growth factor	TNF-alpha	18049(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Nerve_growth_factor regulates TNF-alpha production in mouse macrophages via MAP kinase activation .
21473865	0	Nerve_growth_factor	0,19	TRPV1	30,35	Nerve growth factor	TRPV1	310738(Tax:10116)	83810(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Nerve_growth_factor modulates TRPV1 expression and function and mediates pain in chronic_pancreatitis .
16453742	0	Nerve_growth_factor	0,19	Thy-1	30,35	Nerve growth factor	Thy-1	310738(Tax:10116)	24832(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Nerve_growth_factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells .
9715270	0	Nerve_growth_factor	0,19	Trk	56,59	Nerve growth factor	Trk	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY requires|nsubj|stimulation requires|dobj|interaction interaction|compound|END_ENTITY	Nerve_growth_factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide_3-OH kinase .
12133829	0	Nerve_growth_factor	0,19	TrkA	36,40	Nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Nerve_growth_factor signals through TrkA , phosphatidylinositol 3-kinase , and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells .
17548467	0	Nerve_growth_factor	0,19	TrkA	52,56	Nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|concentration concentration|nmod|END_ENTITY	Nerve_growth_factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein .
23912036	0	Nerve_growth_factor	0,19	TrkA	37,41	Nerve growth factor	TrkA	4803	59109(Tax:10116)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|receptor receptor|compound|END_ENTITY	Nerve_growth_factor acts through the TrkA receptor to protect sensory neurons from the damaging effects of the HIV-1 viral protein , Vpr .
8987776	0	Nerve_growth_factor	0,19	TrkA	87,91	Nerve growth factor	TrkA	4803	4914	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|acl:relcl|express express|dobj|receptors receptors|compound|END_ENTITY	Nerve_growth_factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors .
11359873	0	Nerve_growth_factor	0,19	beta-amyloid_precursor_protein	62,92	Nerve growth factor	beta-amyloid precursor protein	310738(Tax:10116)	54226(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Nerve_growth_factor modulates the expression and secretion of beta-amyloid_precursor_protein through different mechanisms in PC12 cells .
8667031	0	Nerve_growth_factor	0,19	beta-amyloid_precursor_protein	37,67	Nerve growth factor	beta-amyloid precursor protein	310738(Tax:10116)	54226(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Nerve_growth_factor and ras regulate beta-amyloid_precursor_protein gene expression in PC12 cells .
9622194	0	Nerve_growth_factor	0,19	beta3-adrenoceptor	21,39	Nerve growth factor	beta3-adrenoceptor	310738(Tax:10116)	25645(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Nerve_growth_factor , beta3-adrenoceptor and uncoupling protein 1 expression in rat brown fat during postnatal development .
22773372	0	Nerve_growth_factor	0,19	calreticulin	64,76	Nerve growth factor	calreticulin	4803	811	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Nerve_growth_factor induces the expression of chaperone protein calreticulin in human epithelial ovarian cells .
2130652	0	Nerve_growth_factor	0,19	choline_acetyltransferase	74,99	Nerve growth factor	choline acetyltransferase	310738(Tax:10116)	290567(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|increase increase|nmod|activity activity|amod|END_ENTITY	Nerve_growth_factor induces a dose-dependent and long-lasting increase of choline_acetyltransferase activity in the septal area and hippocampus of uninjured rats .
9067843	0	Nerve_growth_factor	0,19	galanin	28,35	Nerve growth factor	galanin	310738(Tax:10116)	29141(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nerve_growth_factor induces galanin gene expression in the rat basal_forebrain : implications for the treatment of cholinergic_dysfunction .
10221670	0	Nerve_growth_factor	0,19	myelin-associated_glycoprotein	30,60	Nerve growth factor	myelin-associated glycoprotein	4803	4099	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Nerve_growth_factor modulates myelin-associated_glycoprotein binding to sensory neurons .
25945243	0	Nerve_growth_factor	0,19	nerve_growth_factor	46,65	Nerve growth factor	nerve growth factor	4803	4803	Gene	Gene	START_ENTITY|dep|Effect Effect|nmod|END_ENTITY	Nerve_growth_factor in human semen : Effect of nerve_growth_factor on the normozoospermic men during cryopreservation process .
25945243	0	Nerve_growth_factor	0,19	nerve_growth_factor	46,65	Nerve growth factor	nerve growth factor	4803	4803	Gene	Gene	START_ENTITY|dep|Effect Effect|nmod|END_ENTITY	Nerve_growth_factor in human semen : Effect of nerve_growth_factor on the normozoospermic men during cryopreservation process .
10228123	0	Nerve_growth_factor	0,19	neurokinin-1_receptor	30,51	Nerve growth factor	neurokinin-1 receptor	4803	100135626(Tax:10141)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Nerve_growth_factor induces a neurokinin-1_receptor - mediated airway hyperresponsiveness in guinea_pigs .
3511068	0	Nerve_growth_factor	0,19	neuron-glia_cell_adhesion_molecule	43,77	Nerve growth factor	neuron-glia cell adhesion molecule	310738(Tax:10116)	50687(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Nerve_growth_factor enhances expression of neuron-glia_cell_adhesion_molecule in PC12 cells .
8730811	0	Nerve_growth_factor	0,19	neuropeptide_Y	45,59	Nerve growth factor	neuropeptide Y	4803	4852	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Nerve_growth_factor stimulates production of neuropeptide_Y in human lymphocytes .
10626843	0	Nerve_growth_factor	0,19	neurotrophin-3	36,50	Nerve growth factor	neurotrophin-3	18049(Tax:10090)	18205(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY driven|nsubj|promoter driven|dobj|overexpression overexpression|amod|END_ENTITY	Nerve_growth_factor promoter driven neurotrophin-3 overexpression in the mouse and the protective effect of transgene on age-related behavioral_deficits .
10713062	0	Nerve_growth_factor	0,19	p75	68,71	Nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|kappaB kappaB|nmod|receptor receptor|amod|END_ENTITY	Nerve_growth_factor activation of nuclear factor kappaB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells .
11746763	0	Nerve_growth_factor	0,19	p75	33,36	Nerve growth factor	p75	4803	11168	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Nerve_growth_factor signaling of p75 induces differentiation and ceramide-mediated apoptosis in Schwann cells cultured from degenerating nerves .
11818506	0	Nerve_growth_factor	0,19	p75	95,98	Nerve growth factor	p75	4803	7133	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|D D|dep|expression expression|nmod|lines lines|nmod|END_ENTITY	Nerve_growth_factor regulates dopamine D -LRB- 2 -RRB- receptor expression in prolactinoma cell lines via p75 -LRB- NGFR -RRB- - mediated activation of nuclear_factor-kappaB .
19229990	0	Nerve_growth_factor	0,19	p75	67,70	Nerve growth factor	p75	4803	7133	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|proliferation proliferation|nmod|astrocytes astrocytes|nmod|receptor receptor|amod|END_ENTITY	Nerve_growth_factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor .
9061691	0	Nerve_growth_factor	0,19	p75	49,52	Nerve growth factor	p75	18049(Tax:10090)	18053(Tax:10090)	Gene	Gene	START_ENTITY|dobj|production production|nmod|END_ENTITY	Nerve_growth_factor production and expression of p75 by Schwann cells and neurofibroblasts in response to M. _ leprae infection and macrophage secretory products .
9466406	0	Nerve_growth_factor	0,19	p75	128,131	Nerve growth factor	p75	18049(Tax:10090)	18053(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|sites sites|nmod|neurons neurons|nmod|END_ENTITY	Nerve_growth_factor regulates the expression of bradykinin binding sites on adult sensory neurons via the neurotrophin receptor p75 .
9835221	0	Nerve_growth_factor	0,19	p75	95,98	Nerve growth factor	p75	18049(Tax:10090)	18053(Tax:10090)	Gene	Gene	evokes|nsubj|START_ENTITY evokes|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Nerve_growth_factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75 .
2542296	0	Nerve_growth_factor	0,19	proto-oncogene_c-jun	32,52	Nerve growth factor	proto-oncogene c-jun	310738(Tax:10116)	24516(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Nerve_growth_factor induces the proto-oncogene_c-jun in PC12 cells .
9038227	0	Nerve_growth_factor	0,19	soluble_guanylate_cyclase	30,55	Nerve growth factor	soluble guanylate cyclase	310738(Tax:10116)	25206(Tax:10116)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Nerve_growth_factor decreases soluble_guanylate_cyclase in rat pheochromocytoma PC12 cells .
19019428	0	Nerve_growth_factor	0,19	synaptophysin	30,43	Nerve growth factor	synaptophysin	310738(Tax:10116)	24804(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nerve_growth_factor regulates synaptophysin expression in developing trigeminal_ganglion neurons in vitro .
1715690	0	Nerve_growth_factor	0,19	trk	40,43	Nerve growth factor	trk	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Nerve_growth_factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase_C_gamma_1 .
16935322	0	Nerve_growth_factor	0,19	vascular_endothelial_growth_factor	86,120	Nerve growth factor	vascular endothelial growth factor	4803	7422	Gene	Gene	participate|nsubj|START_ENTITY participate|nmod|control control|nmod|expression expression|compound|END_ENTITY	Nerve_growth_factor and its high-affinity receptor trkA participate in the control of vascular_endothelial_growth_factor expression in epithelial_ovarian_cancer .
24615084	0	Nerve_growth_factor	0,19	vascular_endothelial_growth_factor	48,82	Nerve growth factor	vascular endothelial growth factor	4803	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Nerve_growth_factor regulates the expression of vascular_endothelial_growth_factor in human HaCaT keratinocytes via PI3K/mTOR pathway .
18356286	0	Nescient_helix-loop-helix_2	0,27	signal_transducer_and_activator_of_transcription_3	43,93	Nescient helix-loop-helix 2	signal transducer and activator of transcription 3	18072(Tax:10090)	20848(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nescient_helix-loop-helix_2 interacts with signal_transducer_and_activator_of_transcription_3 to regulate transcription of prohormone_convertase_1 / 3 .
23714076	0	Nesfatin-1	0,10	Fos	19,22	Nesfatin-1	Fos	59295(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nesfatin-1 induces Fos expression and elicits dipsogenic responses in subfornical organ .
25949163	0	Nesfatin-1	14,24	NUCB2	25,30	Nesfatin-1	NUCB2	53322(Tax:10090)	53322(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of Nesfatin-1 / NUCB2 in Fetal , Neonatal and Adult Mice .
26091086	0	Nestin	25,31	CD44	33,37	Nestin	CD44	25491(Tax:10116)	25406(Tax:10116)	Gene	Gene	Vascular_Endothelial_Growth_Factor|compound|START_ENTITY Vascular_Endothelial_Growth_Factor|appos|END_ENTITY	Changes in Expression of Nestin , CD44 , Vascular_Endothelial_Growth_Factor , and Glutamine Synthetase by Mature M ller Cells After Dedifferentiation .
21346193	0	Nestin	0,6	Cdk5	25,29	Nestin	Cdk5	10763	1020	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Nestin as a regulator of Cdk5 in differentiating myoblasts .
24462842	0	Nestin	52,58	Epidermal_growth_factor	0,23	Nestin	Epidermal growth factor	25491(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Epidermal_growth_factor increases the expression of Nestin in rat reactive astrocytes through the Ras-Raf-ERK pathway .
11584016	0	Nestin	0,6	thyroid_transcription_factor-1	43,73	Nestin	thyroid transcription factor-1	18008(Tax:10090)	21869(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Nestin is a neuroepithelial target gene of thyroid_transcription_factor-1 , a homeoprotein required for forebrain organogenesis .
14729959	0	Net	34,37	p53	21,24	p53	p53	7157	7157	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The tumor suppressor p53 inhibits Net , an effector of Ras/extracellular signal-regulated kinase signaling .
11960554	0	Net1	35,39	Cdc5	0,4	Net1	Cdc5	10276	988	Gene	Gene	phosphorylation|nmod|START_ENTITY influences|dobj|phosphorylation influences|nsubj|END_ENTITY	Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex .
12056824	0	Net1	34,38	Cdc5	14,18	Net1	Cdc5	853369(Tax:4932)	855013(Tax:4932)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Budding yeast Cdc5 phosphorylates Net1 and assists Cdc14 release from the nucleolus .
25486363	0	Net1A	84,89	ATM	37,40	Net1A	ATM	10276	472	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Rho GTPase independent regulation of ATM activation and cell survival by the RhoGEF Net1A .
26277340	0	Neto1	23,28	GluK1	95,100	Neto1	GluK1	81832	2897	Gene	Gene	have|nsubj|START_ENTITY have|dobj|effects effects|nmod|END_ENTITY	The auxiliary subunits Neto1 and Neto2 have distinct , subunit-dependent effects at recombinant GluK1 - and GluK2-containing kainate receptors .
12799072	0	Netrin-1	14,22	DCC	45,48	Netrin-1	DCC	18208(Tax:10090)	13176(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung .
15557120	0	Netrin-1	39,47	DCC	19,22	Netrin-1	DCC	373694(Tax:8355)	378529(Tax:8355)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance .
19409494	0	Netrin-1	22,30	DCC	48,51	Netrin-1	DCC	18208(Tax:10090)	13176(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration .
25950802	0	Netrin-1	0,8	DCC	11,14	Netrin-1	DCC	9423	1630	Gene	Gene	START_ENTITY|dep|Systems Systems|compound|END_ENTITY	Netrin-1 - DCC Signaling Systems and Age-Related Macular_Degeneration .
9950216	0	Netrin-1	0,8	DCC	57,60	Netrin-1	DCC	9423	1630	Gene	Gene	START_ENTITY|dep|interaction interaction|nmod|deleted_in_colorectal_cancer deleted_in_colorectal_cancer|appos|END_ENTITY	Netrin-1 : interaction with deleted_in_colorectal_cancer -LRB- DCC -RRB- and alterations in brain_tumors and neuroblastomas .
24738865	0	Netrin-1	0,8	E-cadherin	34,44	Netrin-1	E-cadherin	18208(Tax:10090)	12550(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCa and FAK/Fyn in promoting mesenchymal stem cell motility .
11844789	0	Netrin-1	103,111	Rac1	0,4	Netrin-1	Rac1	18208(Tax:10090)	19353(Tax:10090)	Gene	Gene	DCC|compound|START_ENTITY induced|nmod|DCC outgrowth|acl|induced required|nmod|outgrowth required|nsubjpass|END_ENTITY	Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC -LRB- deleted_in_colorectal_cancer -RRB- in N1E-115 neuroblastoma cells .
22915753	0	Netrin-1	60,68	TNF-a	0,5	Netrin-1	TNF-a	18208(Tax:10090)	21926(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	TNF-a mediates macrophage-induced bystander effects through Netrin-1 .
17908930	0	Netrin-1	36,44	UNC5B	18,23	Netrin-1	UNC5B	9423	219699	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis .
9950216	0	Netrin-1	0,8	deleted_in_colorectal_cancer	27,55	Netrin-1	deleted in colorectal cancer	9423	1630	Gene	Gene	START_ENTITY|dep|interaction interaction|nmod|END_ENTITY	Netrin-1 : interaction with deleted_in_colorectal_cancer -LRB- DCC -RRB- and alterations in brain_tumors and neuroblastomas .
10366627	0	Netrin-3	0,8	NTN2L	35,40	Netrin-3	NTN2L	18209(Tax:10090)	4917	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Netrin-3 , a mouse homolog of human NTN2L , is highly expressed in sensory ganglia and shows differential binding to netrin receptors .
10611246	0	Neu	54,57	Cyclin_D1	0,9	Neu	Cyclin D1	2064	595	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Cyclin_D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway .
26351488	0	Neu	32,35	ER	15,17	Neu	ER	2064	2099	Gene	Gene	Correlation|dep|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of ER , PR and HER-2 / Neu with other Prognostic Factors in Infiltrating Ductal_Carcinoma of Breast .
11314013	0	Neu	127,130	ErbB-2	120,126	Neu	ErbB-2	2064	403883(Tax:9615)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2 / Neu receptor .
18182136	0	Neu	27,30	her-2	20,25	Neu	her-2	2064	2064	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Immunohistochemical her-2 / Neu expression with gene amplification by fluorescence in situ hybridization for assessment in breast_carcinomas .
16869890	0	Neu2	69,73	cytosolic_sialidase	49,68	Neu2	cytosolic sialidase	23956(Tax:10090)	23956(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor_1 signaling regulates cytosolic_sialidase Neu2 expression during myoblast differentiation and hypertrophy .
26164608	0	NeuN	61,65	GFAP	136,140	NeuN	GFAP	287847(Tax:10116)	24387(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Upregulation effects of Tanshinone_IIA on the expressions of NeuN , Nissl body , and IkB and downregulation effects on the expressions of GFAP and NF-kB in the brain tissues of rat models of Alzheimer 's _ disease .
7929212	0	Neu_differentiation_factor	84,110	ErbB-3	0,6	Neu differentiation factor	ErbB-3	3084	2065	Gene	Gene	heregulin|compound|START_ENTITY function|nmod|heregulin function|amod|END_ENTITY	ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu_differentiation_factor / heregulin isoforms .
8524214	0	Neu_differentiation_factor	0,26	ErbB-3	41,47	Neu differentiation factor	ErbB-3	3084	2065	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Neu_differentiation_factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2 .
7592681	0	Neu_differentiation_factor	11,37	Her2	71,75	Neu differentiation factor	Her2	3084	2064	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Neu_differentiation_factor with the extracellular domain of Her2 and Her3 .
8106145	0	Neu_differentiation_factor	0,26	intercellular_adhesion_molecule_1	61,94	Neu differentiation factor	intercellular adhesion molecule 1	3084	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Neu_differentiation_factor -LRB- heregulin -RRB- induces expression of intercellular_adhesion_molecule_1 : implications for mammary_tumors .
11952639	0	Neural_Wiskott-Aldrich_syndrome_protein	0,39	VirG	85,89	Neural Wiskott-Aldrich syndrome protein	VirG	8976	7433	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading .
23212915	0	Neural_Wiskott-Aldrich_syndrome_protein	0,39	p120-catenin	58,70	Neural Wiskott-Aldrich syndrome protein	p120-catenin	8976	1500	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	Neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- - mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions .
12743109	0	Neural_cell_adhesion_molecule	0,29	NCAM	31,35	Neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	association|amod|START_ENTITY association|appos|END_ENTITY	Neural_cell_adhesion_molecule -LRB- NCAM -RRB- association with PKCbeta2 via betaI_spectrin is implicated in NCAM-mediated neurite outgrowth .
18213713	0	Neural_cell_adhesion_molecule	0,29	NCAM	31,35	Neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Neural_cell_adhesion_molecule -LRB- NCAM -RRB- isoform expression is associated with neuroblastoma differentiation status .
21900244	0	Neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2	0,74	Nedd4-2	76,83	Neural precursor cell-expressed developmentally down-regulated protein 4-2	Nedd4-2	23327	23327	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2 -LRB- Nedd4-2 -RRB- regulation by 14-3-3 protein binding at canonical serum_and_glucocorticoid_kinase_1 -LRB- SGK1 -RRB- phosphorylation sites .
744553	0	Neuraminidase	0,13	NAG	26,29	Neuraminidase	NAG	4758	51594	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Neuraminidase activity of NAG vibrios and of some representatives of the intestinal group of bacteria .
24564719	0	Neuraminidase	58,71	neuraminidase	107,120	Neuraminidase	neuraminidase	4758	4758	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Structural analysis of the novel influenza A -LRB- H7N9 -RRB- viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir , Zanamivir , and Peramivir in the presence of mutation R289K .
20651836	0	Neuregulin-1	0,12	Akt	41,44	Neuregulin-1	Akt	112400(Tax:10116)	24185(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Neuregulin-1 regulates the expression of Akt , Bcl-2 , and Bad signaling after focal cerebral_ischemia in rats .
15147836	0	Neuregulin-1	0,12	Egr-1	35,40	Neuregulin-1	Egr-1	3084	1958	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Neuregulin-1 induces expression of Egr-1 and activates acetylcholine receptor transcription through an Egr-1-binding site .
18760695	0	Neuregulin-1	0,12	ErbB	13,17	Neuregulin-1	ErbB	211323(Tax:10090)	13649(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|serves serves|nsubj|signaling signaling|compound|END_ENTITY	Neuregulin-1 / ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system .
20933198	0	Neuregulin-1	0,12	ErbB	13,17	Neuregulin-1	ErbB	3084	1956	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Neuregulin-1 / ErbB signaling and chronic_heart_failure .
23703525	0	Neuregulin-1	0,12	ErbB4	13,18	Neuregulin-1	ErbB4	112400(Tax:10116)	59323(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Neuregulin-1 / ErbB4 signaling regulates Kv4.2-mediated transient outward K + current through the Akt/mTOR pathway .
25080381	0	Neuregulin-1	0,12	connexin-40	23,34	Neuregulin-1	connexin-40	211323(Tax:10090)	14613(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Neuregulin-1 increases connexin-40 and connexin-45 expression in embryonic stem cell-derived cardiomyocytes .
25068025	0	Neuregulin-1	0,12	erbB	13,17	Neuregulin-1	erbB	3084	1956	Gene	Gene	START_ENTITY|dep|activities activities|amod|END_ENTITY	Neuregulin-1 / erbB activities with focus on the susceptibility of the heart to anthracyclines .
24256316	0	Neuregulin-1	0,12	glial_growth_factor	13,32	Neuregulin-1	glial growth factor	3084	3084	Gene	Gene	START_ENTITY|parataxis|stimulates stimulates|nsubj|END_ENTITY	Neuregulin-1 / glial_growth_factor stimulates Schwann cell migration by inducing a5 b1 integrin-ErbB2-focal_adhesion_kinase complex formation .
20080551	0	Neuregulin_1	0,12	ErbB4	53,58	Neuregulin 1	ErbB4	211323(Tax:10090)	13869(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Neuregulin_1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons .
16527258	0	Neurensin-1	86,97	Neurensin-2	58,69	Neurensin-1	Neurensin-2	22360(Tax:10090)	228777(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Molecular characterization of a transport vesicle protein Neurensin-2 , a homologue of Neurensin-1 , expressed in neural cells .
16527258	0	Neurensin-2	58,69	Neurensin-1	86,97	Neurensin-2	Neurensin-1	228777(Tax:10090)	22360(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Molecular characterization of a transport vesicle protein Neurensin-2 , a homologue of Neurensin-1 , expressed in neural cells .
20064388	0	Neurexin1	22,31	LRRTM2	0,6	Neurexin1	LRRTM2	9378	26045	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation .
20120526	0	Neuro-D	116,123	TNF	111,114	Neuro-D	TNF	4760	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Retinopathy and nephropathy in type 1 diabetic patients -- association with polymorphysms of vitamin_D-receptor , TNF , Neuro-D and IL-1 receptor 1 genes .
20120526	0	Neuro-D	116,123	vitamin_D-receptor	91,109	Neuro-D	vitamin D-receptor	4760	7421	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Retinopathy and nephropathy in type 1 diabetic patients -- association with polymorphysms of vitamin_D-receptor , TNF , Neuro-D and IL-1 receptor 1 genes .
26922803	0	Neuro-oncological_Ventral_Antigen_1	12,47	NOVA1	49,54	Neuro-oncological Ventral Antigen 1	NOVA1	4857	4857	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Upregulated Neuro-oncological_Ventral_Antigen_1 -LRB- NOVA1 -RRB- Expression Is Specific to Mature and Immature T - and NK-Cell Lymphomas .
14726486	0	NeuroD1	29,36	BETA2	37,42	NeuroD1	BETA2	18012(Tax:10090)	18012(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Tpit-independent function of NeuroD1 -LRB- BETA2 -RRB- in pituitary corticotroph differentiation .
24338128	0	NeuroD1	28,35	FMRP	50,54	NeuroD1	FMRP	29458(Tax:10116)	24948(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Translational regulation of NeuroD1 expression by FMRP : involvement in glutamatergic neuronal differentiation of cultured rat primary neural progenitor cells .
18760324	0	NeuroD1	0,7	GnRH_receptor	38,51	NeuroD1	GnRH receptor	18012(Tax:10090)	14715(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	NeuroD1 and Mash1 temporally regulate GnRH_receptor gene expression in immortalized mouse gonadotrope cells .
22310718	0	NeuroD1	0,7	NSCL1	36,41	NeuroD1	NSCL1	18012(Tax:10090)	18071(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	NeuroD1 is an upstream regulator of NSCL1 .
21349947	0	NeuroD1	36,43	Slit2	88,93	NeuroD1	Slit2	4760	9353	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma .
26956881	0	NeuroD1	54,61	Wnt3a	0,5	NeuroD1	Wnt3a	18012(Tax:10090)	22416(Tax:10090)	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|nsubj|END_ENTITY	Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/b-catenin signaling in the hypothalamus .
23100440	0	Neurobeachin	55,67	rugose	11,17	Neurobeachin	rugose	26960	44531(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Drosophila rugose is a functional homolog of mammalian Neurobeachin and affects synaptic architecture , brain morphology , and associative learning .
26578240	0	Neuroblastoma_Amplified_Sequence	0,32	NBAS	34,38	Neuroblastoma Amplified Sequence	NBAS	51594	51594	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Neuroblastoma_Amplified_Sequence -LRB- NBAS -RRB- mutation in recurrent_acute_liver_failure : Confirmatory report in a sibship with very early onset , osteoporosis and developmental_delay .
18572016	0	Neurochondrin	18,31	Dia1	112,116	Neurochondrin	Dia1	23154	1729	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1 .
26916663	0	Neurod1	70,77	CHOP	89,93	Neurod1	CHOP	4760	1649	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Epigallocatechin-3-gallate Inhibits Ethanol-induced apoptosis through Neurod1 Regulating CHOP Expression in Pancreatic b-cells .
25828096	0	Neurod1	22,29	Insm1	0,5	Neurod1	Insm1	18012(Tax:10090)	53626(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic b-cell function .
17185044	0	Neuroendocrine_secretory_protein_55	0,35	NESP55	37,43	Neuroendocrine secretory protein 55	NESP55	24896(Tax:10116)	24896(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Neuroendocrine_secretory_protein_55 -LRB- NESP55 -RRB- immunoreactivity in male and female rat superior cervical ganglion and other sympathetic ganglia .
1786631	0	Neurofibromatosis_type_1	0,24	NF1	26,29	Neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Neurofibromatosis_type_1 -LRB- NF1 -RRB- gene : implication in neuroectodermal differentiation and genesis of brain_tumors .
16324214	0	Neurofibromatosis_type_2	51,75	NF2	77,80	Neurofibromatosis type 2	NF2	4771	4771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evolution and origin of merlin , the product of the Neurofibromatosis_type_2 -LRB- NF2 -RRB- tumor-suppressor gene .
16324214	0	Neurofibromatosis_type_2	51,75	tumor-suppressor	82,98	Neurofibromatosis type 2	tumor-suppressor	4771	7248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Evolution and origin of merlin , the product of the Neurofibromatosis_type_2 -LRB- NF2 -RRB- tumor-suppressor gene .
16405917	0	Neurofibromin	0,13	caveolin-1	23,33	Neurofibromin	caveolin-1	4763	857	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Neurofibromin binds to caveolin-1 and regulates ras , FAK , and Akt .
20171205	0	Neurog1	14,21	Neurogenin_1	0,12	Neurog1	Neurogenin 1	18014(Tax:10090)	18014(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Neurogenin_1 -LRB- Neurog1 -RRB- expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages .
23471965	0	Neurogenin3	0,11	Foxa2	28,33	Neurogenin3	Foxa2	50674	3170	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Neurogenin3 cooperates with Foxa2 to autoactivate its own expression .
20171205	0	Neurogenin_1	0,12	Neurog1	14,21	Neurogenin 1	Neurog1	18014(Tax:10090)	18014(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Neurogenin_1 -LRB- Neurog1 -RRB- expression in the ventral neural tube is mediated by a distinct enhancer and preferentially marks ventral interneuron lineages .
20369290	0	Neuroglycan_C	0,13	pleiotrophin	81,93	Neuroglycan C	pleiotrophin	50568(Tax:10116)	24924(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Neuroglycan_C , a brain-specific chondroitin sulfate proteoglycan , interacts with pleiotrophin , a heparin-binding growth factor .
8243654	0	Neurogranin	0,11	B-50	15,19	Neurogranin	B-50	4900	2596	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Neurogranin , a B-50 / GAP-43-immunoreactive C-kinase substrate -LRB- BICKS -RRB- , is ADP-ribosylated .
9154760	0	Neurokinin-1	0,12	NK1	14,17	Neurokinin-1	NK1	6863	6863	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Neurokinin-1 -LRB- NK1 -RRB- receptors mediate tachykinin-induced depression of GABA current in bullfrog sensory neurons .
11324543	0	Neurokinin-1_receptor	1,22	c-fos	49,54	Neurokinin-1 receptor	c-fos	24807(Tax:10116)	314322(Tax:10116)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	-LSB- Neurokinin-1_receptor mediated formalin-induced c-fos expression in the rat spinal cord -RSB- .
25057795	0	Neurokinin_B	0,12	c-fos	21,26	Neurokinin B	c-fos	6866	14281(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	Neurokinin_B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons .
19755106	0	Neuroligin_2	0,12	gephyrin	85,93	Neuroligin 2	gephyrin	57555	10243	Gene	Gene	drives|nsubj|START_ENTITY drives|nmod|END_ENTITY	Neuroligin_2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin .
10811630	0	Neuromedin_U	0,12	FM3	74,77	Neuromedin U	FM3	10874	10316	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	Neuromedin_U is a potent agonist at the orphan G protein-coupled receptor FM3 .
16878152	0	Neuromedin_U	0,12	RhoGDI2	55,62	Neuromedin U	RhoGDI2	10874	397	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Neuromedin_U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation , lung metastasis and cancer_cachexia .
3037205	0	Neuron-specific_enolase	0,23	CEA	107,110	Neuron-specific enolase	CEA	2026	1084	Gene	Gene	START_ENTITY|nmod|marker marker|nmod|carcinoembryonic_antigen carcinoembryonic_antigen|appos|END_ENTITY	Neuron-specific_enolase -LRB- NSE -RRB- as a tumour marker and comparative evaluation with carcinoembryonic_antigen -LRB- CEA -RRB- in small-cell_lung_cancer .
3429947	0	Neuron-specific_enolase	0,23	CEA	98,101	Neuron-specific enolase	CEA	2026	1084	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Neuron-specific_enolase in the diagnosis and therapy monitoring of lung_cancer : a comparison with CEA , TPA , ferritin and calcitonin .
9137895	0	Neuron-specific_enolase	0,23	S-100	25,30	Neuron-specific enolase	S-100	2026	6285	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Neuron-specific_enolase , S-100 protein , myelin_basic_protein and lactate in CSF in dementia .
23251206	0	Neuronal_Cell_Adhesion_Molecule	19,50	NrCAM	52,57	Neuronal Cell Adhesion Molecule	NrCAM	4897	4897	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of the Neuronal_Cell_Adhesion_Molecule -LRB- NrCAM -RRB- Gene Variants with Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder .
15280366	0	Neuronal_apoptosis-inhibitory_protein	0,37	Smac	61,65	Neuronal apoptosis-inhibitory protein	Smac	4671	56616	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Neuronal_apoptosis-inhibitory_protein does not interact with Smac and requires ATP to bind caspase-9 .
19063943	0	Neuronal_enriched_endosomal_protein_of_21_kDa	0,45	GLUR2/3	90,97	Neuronal enriched endosomal protein of 21 kDa	GLUR2/3	27065	2891;2892	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	Neuronal_enriched_endosomal_protein_of_21_kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic membrane .
26977442	0	Neuronal_growth_regulator_1	76,103	NEGR1	105,110	Neuronal growth regulator 1	NEGR1	257194	257194	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Supporting data for characterization of non-coding RNAs associated with the Neuronal_growth_regulator_1 -LRB- NEGR1 -RRB- adhesion protein .
22981806	0	Neuropeptide_FF	0,15	ERK	26,29	Neuropeptide FF	ERK	8620	5594	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|pathways pathways|compound|END_ENTITY	Neuropeptide_FF activates ERK and NF_kappa_B signal pathways in differentiated SH-SY5Y cells .
23372674	0	Neuropeptide_S_Receptor_1	23,48	NPSR1	50,55	Neuropeptide S Receptor 1	NPSR1	387129	387129	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	DNA methylation in the Neuropeptide_S_Receptor_1 -LRB- NPSR1 -RRB- promoter in relation to asthma and environmental factors .
22484995	0	Neuropeptide_W	0,14	corticotrophin-releasing_factor	67,98	Neuropeptide W	corticotrophin-releasing factor	259224(Tax:10116)	81648(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Neuropeptide_W stimulates adrenocorticotrophic hormone release via corticotrophin-releasing_factor but not via arginine_vasopressin .
26078399	0	Neuropeptide_Y	28,42	Adiponectin	15,26	Neuropeptide Y	Adiponectin	4852	9370	Gene	Gene	Levels|appos|START_ENTITY Levels|compound|END_ENTITY	Plasma Leptin , Adiponectin , Neuropeptide_Y Levels in Drug Naive Children With ADHD .
26813148	0	Neuropeptide_Y	93,107	C-Fos	34,39	Neuropeptide Y	C-Fos	4852	2353	Gene	Gene	Contributes|nmod|START_ENTITY Contributes|nmod|Induction Induction|compound|END_ENTITY	An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide_Y .
2996711	0	Neuropeptide_Y	0,14	CA1	82,85	Neuropeptide Y	CA1	24604(Tax:10116)	310218(Tax:10116)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|spike spike|nmod|END_ENTITY	Neuropeptide_Y reduces orthodromically evoked population spike in rat hippocampal CA1 by a possibly presynaptic mechanism .
26078399	0	Neuropeptide_Y	28,42	Leptin	7,13	Neuropeptide Y	Leptin	4852	3952	Gene	Gene	Levels|appos|START_ENTITY END_ENTITY|appos|Levels	Plasma Leptin , Adiponectin , Neuropeptide_Y Levels in Drug Naive Children With ADHD .
26538454	0	Neuropeptide_Y	87,101	Leptin	207,213	Neuropeptide Y	Leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Associated|nmod|Expression Associated|nmod|Independently Independently|nmod|Changes Changes|nmod|Signaling Signaling|compound|END_ENTITY	Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide_Y and Proopiomelanocortin in the Arcuate Nucleus , Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling .
24965867	0	Neuropeptide_Y	102,116	NPY	118,121	Neuropeptide Y	NPY	4852	4852	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Distribution of peptidergic populations in the human dentate gyrus -LRB- Somatostatin -LSB- SOM-28 , SOM-12 -RSB- and Neuropeptide_Y -LSB- NPY -RSB- -RRB- during postnatal development .
27016395	0	Neuropeptide_Y	0,14	NPY	95,98	Neuropeptide Y	NPY	4852	4852	Gene	Gene	START_ENTITY|dep|levels levels|compound|END_ENTITY	Neuropeptide_Y -LRB- NPY -RRB- in cerebrospinal fluid from patients with Huntington 's _ Disease : increased NPY levels and differential degradation of the NPY1-30 fragment .
27023421	0	Neuropeptide_Y	0,14	NPY	62,65	Neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|receptor receptor|compound|END_ENTITY	Neuropeptide_Y inhibits the trigeminovascular pathway through NPY Y1 receptor : implications for migraine .
18500388	0	Neuropeptide_Y	0,14	TGF-beta1	24,33	Neuropeptide Y	TGF-beta1	109648(Tax:10090)	21803(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	Neuropeptide_Y promotes TGF-beta1 production in RAW264 .7 cells by activating PI3K pathway via Y1 receptor .
19456245	0	Neuropeptide_Y	0,14	c-Fos	25,30	Neuropeptide Y	c-Fos	24604(Tax:10116)	314322(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Neuropeptide_Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median_nerve_injury .
8581487	0	Neuropeptide_Y	0,14	c-Fos	69,74	Neuropeptide Y	c-Fos	24604(Tax:10116)	314322(Tax:10116)	Gene	Gene	injection|amod|START_ENTITY stimulates|nsubj|injection stimulates|dobj|expression expression|amod|END_ENTITY	Neuropeptide_Y injection into the fourth cerebroventricle stimulates c-Fos expression in the paraventricular nucleus and other nuclei in the forebrain : effect of food consumption .
26621486	0	Neuropeptide_Y	0,14	fibroblast_activation_protein	47,76	Neuropeptide Y	fibroblast activation protein	4852	2191	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Neuropeptide_Y is a physiological substrate of fibroblast_activation_protein : Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver_cirrhosis and hepatocellular_carcinoma .
2884793	0	Neuropeptide_Y	0,14	growth_hormone	33,47	Neuropeptide Y	growth hormone	4852	2688	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Neuropeptide_Y directly inhibits growth_hormone secretion by human pituitary_somatotropic_tumours .
17207896	0	Neuropeptide_Y	0,14	interleukin-1beta	57,74	Neuropeptide Y	interleukin-1beta	109648(Tax:10090)	16176(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|release release|acl|evoked evoked|nmod|cells cells|amod|END_ENTITY	Neuropeptide_Y regulates catecholamine release evoked by interleukin-1beta in mouse chromaffin cells .
3306435	0	Neuropeptide_Y	0,14	luteinizing_hormone-releasing_hormone	41,78	Neuropeptide Y	luteinizing hormone-releasing hormone	24604(Tax:10116)	25194(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Neuropeptide_Y stimulates the release of luteinizing_hormone-releasing_hormone from medial basal hypothalamus in vitro : modulation by ovarian hormones .
7898071	0	Neuropeptide_Y	0,14	renin	41,46	Neuropeptide Y	renin	24604(Tax:10116)	24715(Tax:10116)	Gene	Gene	infusion|amod|START_ENTITY decreases|nsubj|infusion decreases|dobj|activity activity|compound|END_ENTITY	Neuropeptide_Y infusion decreases plasma renin activity in postmyocardial_infarction rats .
22629465	0	Neuropeptide_Y2_receptor	0,24	NPY2R	26,31	Neuropeptide Y2 receptor	NPY2R	4887	4887	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Neuropeptide_Y2_receptor -LRB- NPY2R -RRB- expression in saliva predicts feeding immaturity in the premature_neonate .
1665897	0	Neuropeptide_gamma	0,18	NK2_receptor	114,126	Neuropeptide gamma	NK2 receptor	6863	6865	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Neuropeptide_gamma , the most potent contractile tachykinin in human isolated bronchus , acts via a ` non-classical ' NK2_receptor .
17178835	0	Neuropilin-1	0,12	E2F1	60,64	Neuropilin-1	E2F1	18186(Tax:10090)	13555(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral_ischemia-induced neuronal_death in vivo .
19175293	0	Neuropilin-1	0,12	GIPC1	13,18	Neuropilin-1	GIPC1	18186(Tax:10090)	67903(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Neuropilin-1 / GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells .
12613545	0	Neuropilin-1	19,31	VEGF	84,88	Neuropilin-1	VEGF	8829	7422	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF .
18769069	0	Neuropilin-1	0,12	VEGF	39,43	Neuropilin-1	VEGF	100286859(Tax:9823)	397157(Tax:9823)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Neuropilin-1 is essential for enhanced VEGF -LRB- 165 -RRB- - mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs .
11986311	0	Neuropilin-1	0,12	vascular_endothelial_growth_factor	19,53	Neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Neuropilin-1 binds vascular_endothelial_growth_factor 165 , placenta growth factor-2 , and heparin via its b1b2 domain .
15522955	0	Neuropilin-1	0,12	vascular_endothelial_growth_factor	78,112	Neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|nmod|receptor-2 receptor-2|compound|END_ENTITY	Neuropilin-1 regulates attachment in human endothelial cells independently of vascular_endothelial_growth_factor receptor-2 .
19857463	0	Neuropilin-1	0,12	vascular_endothelial_growth_factor	34,68	Neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complexes complexes|nmod|cells cells|amod|END_ENTITY	Neuropilin-1 forms complexes with vascular_endothelial_growth_factor receptor-2 during megakaryocytic differentiation of UT-7 / TPO cells .
9529250	0	Neuropilin-1	0,12	vascular_endothelial_growth_factor	93,127	Neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|receptor receptor|nmod|END_ENTITY	Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular_endothelial_growth_factor .
26030152	0	Neuropilin-2	0,12	PAX8	45,49	Neuropilin-2	PAX8	81527(Tax:10116)	81819(Tax:10116)	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells .
9331348	0	Neuropilin-2	0,12	Sema_E	103,109	Neuropilin-2	Sema E	8828	10512	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Neuropilin-2 , a novel member of the neuropilin family , is a high affinity receptor for the semaphorins Sema_E and Sema_IV but not Sema_III .
25752543	0	Neuropilin-2	39,51	VEGF-C	21,27	neuropilin-2	VEGF-C	8828	7424	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form .
21880798	0	Neuropilin-2	0,12	VEGF-D	73,79	Neuropilin-2	VEGF-D	8828	2277	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|amod|END_ENTITY	Neuropilin-2 expression in papillary_thyroid_carcinoma : correlation with VEGF-D expression , lymph_node_metastasis , and VEGF-D-induced aggressive cancer cell phenotype .
16621967	0	Neuropilin-2	0,12	VEGFR-2	28,35	Neuropilin-2	VEGFR-2	8828	3791	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration .
26991001	0	Neuropilin-2	22,34	Vascular_Endothelial_Growth_Factor	80,114	Neuropilin-2	Vascular Endothelial Growth Factor	8828	7422	Gene	Gene	Studies|nmod|START_ENTITY Reveal|nsubj|Studies Reveal|advmod|Away Away|nmod|Pocket Pocket|compound|END_ENTITY	Structural Studies of Neuropilin-2 Reveal a Zinc Ion Binding Site Away from the Vascular_Endothelial_Growth_Factor Binding Pocket .
9856463	0	Neuropilin-2	0,12	semaphorin_IV	31,44	Neuropilin-2	semaphorin IV	8828	6405	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Neuropilin-2 is a receptor for semaphorin_IV : insight into the structural basis of receptor function and specificity .
10748121	0	Neuropilin-2	0,12	vascular_endothelial_growth_factor	35,69	Neuropilin-2	vascular endothelial growth factor	8828	7422	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Neuropilin-2 is a receptor for the vascular_endothelial_growth_factor -LRB- VEGF -RRB- forms VEGF-145 and VEGF-165 -LSB- corrected -RSB- .
16638018	0	Neuropilin1	0,11	Nurr1	45,50	Neuropilin1	Nurr1	18186(Tax:10090)	18227(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem .
26097868	0	Neuropilin_1	143,155	MiR-148a	0,8	Neuropilin 1	MiR-148a	8829	406940	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MiR-148a , a microRNA upregulated in the WNT subgroup tumors , inhibits invasion and tumorigenic potential of medulloblastoma cells by targeting Neuropilin_1 .
16849336	0	Neuroserpin	0,11	Abeta	18,23	Neuroserpin	Abeta	49805(Tax:7227)	31002(Tax:7227)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer_disease .
15156571	0	Neurotensin	0,11	Akt	33,36	Neurotensin	Akt	4922	207	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	Neurotensin negatively modulates Akt activity in neurotensin_receptor-1-transfected AV12 cells .
12064480	0	Neurotensin	0,11	DARPP-32	22,30	Neurotensin	DARPP-32	67405(Tax:10090)	19049(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Neurotensin regulates DARPP-32 thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors .
22138429	0	Neurotensin	0,11	Egr-1	20,25	Neurotensin	Egr-1	67405(Tax:10090)	13653(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY activity|compound|END_ENTITY	Neurotensin induced Egr-1 activity is altered in the postpartum period in mice .
8938747	0	Neurotensin	0,11	Fos	20,23	Neurotensin	Fos	299757(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Neurotensin induces Fos and Zif268 expression in limbic nuclei of the rat brain .
15733655	0	Neurotensin	0,11	NTR1	30,34	Neurotensin	NTR1	4922	4923	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Neurotensin activation of the NTR1 on spinally-projecting serotonergic neurons in the rostral ventromedial medulla is antinociceptive .
21394204	0	Neurotensin	0,11	NTSR1	29,34	Neurotensin	NTSR1	4922	4923	Gene	Gene	receptor|compound|START_ENTITY receptor|acl:relcl|polymorphism polymorphism|nsubj|gene gene|appos|END_ENTITY	Neurotensin receptor 1 gene -LRB- NTSR1 -RRB- polymorphism is associated with working memory .
25644759	0	Neurotensin	0,11	NTSR1	65,70	Neurotensin	NTSR1	4922	4923	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Neurotensin promotes the progression of malignant_glioma through NTSR1 and impacts the prognosis of glioma patients .
25644759	0	Neurotensin	0,11	NTSR1	65,70	Neurotensin	NTSR1	4922	4923	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Neurotensin promotes the progression of malignant_glioma through NTSR1 and impacts the prognosis of glioma patients .
15177934	0	Neurotensin	84,95	PI3-kinase_and_EGF-receptor	27,54	Neurotensin	PI3-kinase and EGF-receptor	4922	1956	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of MAP-kinase , PI3-kinase_and_EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells .
1650705	0	Neurotensin	0,11	angiotensin-II	47,61	Neurotensin	angiotensin-II	299757(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Neurotensin inhibits the stimulatory effect of angiotensin-II and potassium on aldosterone secretion by rat zona glomerulosa cells .
15755906	0	Neurotensin	0,11	interleukin-8	23,36	Neurotensin	interleukin-8	4922	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Neurotensin stimulates interleukin-8 expression through modulation of I_kappa_B_alpha phosphorylation and p65 transcriptional activity : involvement of protein_kinase_C_alpha .
3561863	0	Neurotensin	0,11	neurotensin	99,110	Neurotensin	neurotensin	4922	4922	Gene	Gene	START_ENTITY|dep|localization localization|nmod|END_ENTITY	Neurotensin in the human fallopian tube : immunohistochemical localization and effects of synthetic neurotensin on motor activity in vitro .
7070589	0	Neurotensin	0,11	prolactin	27,36	Neurotensin	prolactin	299757(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Neurotensin stimulation of prolactin secretion in vitro .
15755906	0	Neurotensin	0,11	protein_kinase_C_alpha	151,173	Neurotensin	protein kinase C alpha	4922	5578	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|involvement involvement|nmod|END_ENTITY	Neurotensin stimulates interleukin-8 expression through modulation of I_kappa_B_alpha phosphorylation and p65 transcriptional activity : involvement of protein_kinase_C_alpha .
11912133	0	Neurotensin	0,11	protein_kinase_D	47,63	Neurotensin	protein kinase D	4922	5587	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	Neurotensin induces protein_kinase_C-dependent protein_kinase_D activation and DNA synthesis in human pancreatic_carcinoma cell line PANC-1 .
17230532	0	Neurotensin	0,11	response_gene-1_and_EGF_receptor	50,82	Neurotensin	response gene-1 and EGF receptor	4922	1956	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Neurotensin stimulates expression of early growth response_gene-1_and_EGF_receptor through MAP kinase activation in human colonic epithelial cells .
23315174	0	Neurotrophic_tyrosine_kinase_receptor_type_2	0,44	NTRK2	46,51	Neurotrophic tyrosine kinase receptor type 2	NTRK2	4915	4915	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Neurotrophic_tyrosine_kinase_receptor_type_2 -LRB- NTRK2 -RRB- gene associated with treatment response to mood stabilizers in patients with bipolar_I_disorder .
20811452	0	Neurotrophin	0,12	TrkB	66,70	Neurotrophin	TrkB	627	4915	Gene	Gene	TrkA|compound|START_ENTITY neuronal_death|nsubj|TrkA neuronal_death|advcl|does does|nsubj|END_ENTITY	Neurotrophin receptors TrkA and TrkC cause neuronal_death whereas TrkB does not .
25538243	0	Neurotrophin	0,12	TrkB	27,31	Neurotrophin	TrkB	627	4915	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|Receptors Receptors|compound|END_ENTITY	Neurotrophin signaling via TrkB and TrkC Receptors promote the growth of Brain_Tumor Initiating Cells .
7537086	0	Neurotrophin	0,12	alpha_2-macroglobulin	30,51	Neurotrophin	alpha 2-macroglobulin	627	2	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Neurotrophin binding to human alpha_2-macroglobulin under apparent equilibrium conditions .
12169297	0	Neurotrophin	0,12	p75_neurotrophin_receptor	35,60	Neurotrophin	p75 neurotrophin receptor	627	4804	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Neurotrophin signaling through the p75_neurotrophin_receptor .
15140194	0	Neurotrophin-3	0,14	Bcl-2	62,67	Neurotrophin-3	Bcl-2	4908	596	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Neurotrophin-3 and a CREB-mediated signaling pathway regulate Bcl-2 expression in oligodendrocyte progenitor cells .
21151544	0	Neurotrophin-3	24,38	NT-3	40,44	Neurotrophin-3	NT-3	4908	4908	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Placental Neurotrophin-3 -LRB- NT-3 -RRB- in Physiological Pregnancy , Preeclampsia_and_Chorioamnionitis .
7955419	0	Neurotrophin-3	0,14	NT-3	16,20	Neurotrophin-3	NT-3	81737(Tax:10116)	81737(Tax:10116)	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Neurotrophin-3 -LRB- NT-3 -RRB- levels in the developing rat nervous system and in human samples .
21828999	0	Neurotrophin-3	0,14	TrkC	51,55	Neurotrophin-3	TrkC	4908	4916	Gene	Gene	cells|amod|START_ENTITY promote|nsubj|cells promote|ccomp|stem stem|nsubj|mesenchymal mesenchymal|amod|END_ENTITY	Neurotrophin-3 gene-modified Schwann cells promote TrkC gene-modified mesenchymal stem cells to differentiate into neuron-like cells in poly -LRB- lactic-acid-co-glycolic_acid -RRB- multiple-channel conduit .
23746279	0	Neurotrophin-3	0,14	TrkC	77,81	Neurotrophin-3	TrkC	4908	4916	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|migration migration|nmod|cells cells|acl|overexpressing overexpressing|dobj|END_ENTITY	Neurotrophin-3 stimulates migration of mesenchymal stem cells overexpressing TrkC .
8626576	0	Neurotrophin-3	0,14	TrkC	119,123	Neurotrophin-3	TrkC	81737(Tax:10116)	29613(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|action action|nmod|receptor receptor|compound|END_ENTITY	Neurotrophin-3 increases intracellular calcium in a rat insulin-secreting cell line through its action on a functional TrkC receptor .
14511333	0	Neurotrophin-3	0,14	trkA	30,34	Neurotrophin-3	trkA	81737(Tax:10116)	59109(Tax:10116)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|mRNA mRNA|compound|END_ENTITY	Neurotrophin-3 down-regulates trkA mRNA , NGF high-affinity binding sites , and associated phenotype in adult DRG neurons .
14614136	0	Neurotrophin_3	0,14	TrkC	29,33	Neurotrophin 3	TrkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Neurotrophin_3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway .
17640175	0	Neurotrophins_3_and_4	0,21	NCAM	46,50	Neurotrophins 3 and 4	NCAM	81737;25730	24586(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Neurotrophins_3_and_4 differentially regulate NCAM , L1 and N-cadherin expression during peripheral nerve regeneration .
18393382	0	Neurturin	0,9	activating_transcription_factor_3	45,78	Neurturin	activating transcription factor 3	100719545	100722370	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Neurturin suppresses injury-induced neuronal activating_transcription_factor_3 expression in cultured guinea_pig cardiac ganglia .
23840630	0	Neutral_Sphingomyelinase_2	58,84	Heat_Shock_Protein_60	18,39	Neutral Sphingomyelinase 2	Heat Shock Protein 60	55512	3329	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Heat_Shock_Protein_60 as a Regulator of Neutral_Sphingomyelinase_2 and Its Role in Dopamine Uptake .
1873480	0	Neutrophil-activating_peptide_1	0,31	interleukin_8	32,45	Neutrophil-activating peptide 1	interleukin 8	3576	3576	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Neutrophil-activating_peptide_1 / interleukin_8 mRNA expression and protein secretion by human monocytes : effect of cyclosporin_A .
26116587	0	Neutrophil_Gelatinase-Associated_Lipocalin	10,52	NGAL	54,58	Neutrophil Gelatinase-Associated Lipocalin	NGAL	3934	3934	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	Corrected Neutrophil_Gelatinase-Associated_Lipocalin -LRB- NGAL -RRB- Level Adjusted by the Scoring System of an Inflammation Index for Screening Renal Dysfunction in Patients with Systemic_Inflammation .
26303800	0	Neutrophil_Gelatinase-Associated_Lipocalin	14,56	NGAL	58,62	Neutrophil Gelatinase-Associated Lipocalin	NGAL	3934	3934	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Urine Neutrophil_Gelatinase-Associated_Lipocalin -LRB- NGAL -RRB- in the Early Diagnosis of Amphotericin_B-induced Acute_Kidney_Injury .
26303800	0	Neutrophil_Gelatinase-Associated_Lipocalin	14,56	NGAL	58,62	Neutrophil Gelatinase-Associated Lipocalin	NGAL	3934	3934	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Urine Neutrophil_Gelatinase-Associated_Lipocalin -LRB- NGAL -RRB- in the Early Diagnosis of Amphotericin_B-induced Acute_Kidney_Injury .
21612443	0	Neutrophil_gelatinase-associated_lipocalin	0,42	C/EBPb	113,119	Neutrophil gelatinase-associated lipocalin	C/EBPb	3934	1051	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	Neutrophil_gelatinase-associated_lipocalin in gastric_carcinoma cells and its induction by TPA are controlled by C/EBPb .
22418433	0	Neutrophil_gelatinase-associated_lipocalin	0,42	NGAL	44,48	Neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1 .
21233129	0	Nf1	56,59	ERK	39,42	Nf1	ERK	4763	5594	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Lens induction requires attenuation of ERK signaling by Nf1 .
23082153	0	Nf1	0,3	LIMK2	25,30	Nf1	LIMK2	4763	3985	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways .
23082153	0	Nf1	0,3	RasGAP	4,10	Nf1	RasGAP	4763	5921	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways .
25534823	0	Nf1	48,51	mTOR	21,25	Nf1	mTOR	18015(Tax:10090)	21977(Tax:10090)	Gene	Gene	growth|amod|START_ENTITY suppresses|dobj|growth suppresses|nsubj|inhibition inhibition|compound|END_ENTITY	Akt - or MEK-mediated mTOR inhibition suppresses Nf1 optic_glioma growth .
23506114	0	Nf1	40,43	neurofibromin	20,33	Nf1	neurofibromin	43149(Tax:7227)	43149(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the neurofibromin gene , Nf1 , is associated with antagonistic selection on wing size and development time in Drosophila_melanogaster .
25336744	0	Nf2	21,24	Yap	109,112	Nf2	Yap	4771	10413	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|dobj|END_ENTITY	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap .
11703924	0	Nf2	4,7	merlin	26,32	Nf2	merlin	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	The Nf2 tumor suppressor , merlin , functions in Rac-dependent signaling .
21735477	0	Nfatc1	115,121	Jmjd3	77,82	Nfatc1	Jmjd3	4772	23135	Gene	Gene	demethylation|nmod|START_ENTITY END_ENTITY|nmod|demethylation	Epigenetic regulation of osteoclast differentiation : possible involvement of Jmjd3 in the histone demethylation of Nfatc1 .
11786533	0	Nfatc1	25,31	NFATc2	40,46	Nfatc1	NFATc2	18018(Tax:10090)	18019(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the murine Nfatc1 gene by NFATc2 .
21611965	0	Nfatc2	0,6	Nell-1	37,43	Nfatc2	Nell-1	18019(Tax:10090)	338352(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Nfatc2 is a primary response gene of Nell-1 regulating chondrogenesis in ATDC5 cells .
25435940	0	Nfia	36,40	Hes1	18,22	Nfia	Hes1	4774	3280	Gene	Gene	targeting|dobj|START_ENTITY activates|advcl|targeting activates|dobj|END_ENTITY	miR-29a activates Hes1 by targeting Nfia in esophageal_carcinoma cell line TE-1 .
26021864	0	Nfia	23,27	PAX6	0,4	Nfia	PAX6	18027(Tax:10090)	18508(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	PAX6 does not regulate Nfia and Nfib expression during neocortical development .
26021864	0	Nfia	23,27	PAX6	0,4	Nfia	PAX6	18027(Tax:10090)	18508(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	PAX6 does not regulate Nfia and Nfib expression during neocortical development .
10518556	0	Nfia	50,54	nuclear_factor_I-A	25,43	Nfia	nuclear factor I-A	18027(Tax:10090)	18027(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disruption of the murine nuclear_factor_I-A gene -LRB- Nfia -RRB- results in perinatal lethality , hydrocephalus , and agenesis of the corpus_callosum .
22427889	0	Nfkb1	0,5	IFN-b	27,32	Nfkb1	IFN-b	18033(Tax:10090)	15977(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nfkb1 inhibits LPS-induced IFN-b and IL-12_p40 production in macrophages by distinct mechanisms .
19524538	0	Nfkb1	4,9	p105	29,33	Nfkb1	p105	4790	4790	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes .
20598117	0	Nfkb2	19,24	Myc	0,3	Nfkb2	Myc	4791	4609	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Myc suppression of Nfkb2 accelerates lymphomagenesis .
17603005	0	Nfs1	39,43	IscU	69,73	Nfs1	IscU	18041(Tax:10090)	66383(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of the cysteine desulfurase Nfs1 and the scaffold protein IscU in macrophages stimulated with interferon-gamma and lipopolysaccharide .
22943805	0	NgR	23,26	Nogo-A	15,21	NgR	Nogo-A	113912(Tax:10116)	83765(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Expression of Nogo-A , NgR mRNA and protein in the retina of rats with chronic elevated_intraocular_pressure -RSB- .
17630211	0	NgR	67,70	oligodendrocyte_myelin_glycoprotein	14,49	NgR	oligodendrocyte myelin glycoprotein	113912(Tax:10116)	450224(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of oligodendrocyte_myelin_glycoprotein and its receptor NgR after the injury of rat central nervous system .
10777665	0	Ngef	20,24	Dbl	48,51	Ngef	Dbl	25791	4168	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Characterization of Ngef , a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus .
22776709	0	Ngn3	53,57	Pdx1	27,31	Ngn3	Pdx1	11925(Tax:10090)	18609(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The combined expression of Pdx1 and MafA with either Ngn3 or NeuroD improves the differentiation efficiency of mouse embryonic stem cells into insulin-producing cells .
21343251	0	Ngn3	114,118	insulinoma-associated_2	14,37	Ngn3	insulinoma-associated 2	11925(Tax:10090)	56856(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of insulinoma-associated_2 -LRB- INSM2 -RRB- in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1 .
17588536	0	Niban	51,56	eIF2alpha	67,76	Niban	eIF2alpha	116496	83939	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP 1 phosphorylation .
11071914	0	Nic96p	57,63	Nup53p	22,28	Nic96p	Nup53p	850552(Tax:4932)	855184(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The yeast nucleoporin Nup53p specifically interacts with Nic96p and is directly involved in nuclear protein import .
9348540	0	Nic96p	39,45	Nup93	0,5	Nic96p	Nup93	850552(Tax:4932)	380283(Tax:8355)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Nup93 , a vertebrate homologue of yeast Nic96p , forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly .
26717550	0	Nicastrin	0,9	APP	26,29	Nicastrin	APP	23385	351	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Nicastrin is required for APP but not Notch processing , while Aph-1 is dispensable for processing of both APP and Notch .
25996556	0	Nicastrin	20,29	Akt1	0,4	Nicastrin	Akt1	23385	207	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt1 phosphorylates Nicastrin to regulate its protein stability and activity .
11483961	0	Nicastrin	0,9	Notch	37,42	Nicastrin	Notch	172905(Tax:6239)	176282(Tax:6239)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Nicastrin binds to membrane-tethered Notch .
11782315	0	Nicastrin	0,9	Notch	69,74	Nicastrin	Notch	42964(Tax:7227)	31293(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|cleavage cleavage|nmod|receptor receptor|compound|END_ENTITY	Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor .
26389889	0	Nicotinamide_Phosphoribosyltransferase	15,53	NAMPT	55,60	Nicotinamide Phosphoribosyltransferase	NAMPT	10135	10135	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of Nicotinamide_Phosphoribosyltransferase -LRB- NAMPT -RRB- Gene Polymorphisms and of Serum NAMPT Levels with Dilated_Cardiomyopathy in a Chinese Population .
26389889	0	Nicotinamide_Phosphoribosyltransferase	15,53	NAMPT	55,60	Nicotinamide Phosphoribosyltransferase	NAMPT	10135	10135	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of Nicotinamide_Phosphoribosyltransferase -LRB- NAMPT -RRB- Gene Polymorphisms and of Serum NAMPT Levels with Dilated_Cardiomyopathy in a Chinese Population .
20339118	0	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5	0,61	Nox5	63,67	Nicotinamide adenine dinucleotide phosphate reduced oxidase 5	Nox5	79400	79400	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5 -LRB- Nox5 -RRB- regulation by angiotensin_II and endothelin-1 is mediated via calcium/calmodulin-dependent , rac-1-independent pathways in human endothelial cells .
20339118	0	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5	0,61	angiotensin_II	83,97	Nicotinamide adenine dinucleotide phosphate reduced oxidase 5	angiotensin II	79400	183	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5 -LRB- Nox5 -RRB- regulation by angiotensin_II and endothelin-1 is mediated via calcium/calmodulin-dependent , rac-1-independent pathways in human endothelial cells .
20506278	0	Nicotinamide_phosphoribosyltransferase	0,38	sirtuin_1	39,48	Nicotinamide phosphoribosyltransferase	sirtuin 1	10135	23411	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|END_ENTITY	Nicotinamide_phosphoribosyltransferase / sirtuin_1 pathway is involved in human_immunodeficiency_virus_type_1 Tat-mediated long terminal repeat transactivation .
15908696	0	Niemann-Pick_C1	33,48	NPC1	50,54	Niemann-Pick C1	NPC1	4864	4864	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The sterol-sensing domain of the Niemann-Pick_C1 -LRB- NPC1 -RRB- protein regulates trafficking of low density lipoprotein cholesterol .
19229602	0	Niemann-Pick_C1	21,36	NPC1	46,50	Niemann-Pick C1	NPC1	4864	4864	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	NO-1886 up-regulates Niemann-Pick_C1 protein -LRB- NPC1 -RRB- expression through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
21844200	0	Niemann-Pick_C1-like_1	38,60	Cdc42	17,22	Niemann-Pick C1-like 1	Cdc42	237636(Tax:10090)	12540(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The small GTPase Cdc42 interacts with Niemann-Pick_C1-like_1 -LRB- NPC1L1 -RRB- and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner .
20715096	0	Niemann-Pick_C1_like_1	78,100	CYP7A1	171,177	Niemann-Pick C1 like 1	CYP7A1	29881	1581	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Dietary calcium decreases plasma cholesterol by down-regulation of intestinal Niemann-Pick_C1_like_1 and microsomal triacylglycerol transport protein and up-regulation of CYP7A1 and ABCG_5 / 8 in hamsters .
15099022	0	Niemann-Pick_type_C1_disease	53,81	alpha-synuclein	28,43	Niemann-Pick type C1 disease	alpha-synuclein	4864	6622	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick_type_C1_disease .
19723497	0	Niemann-Pick_type_C2_protein	27,55	Nogo-B_receptor	0,15	Niemann-Pick type C2 protein	Nogo-B receptor	10577	116150	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Nogo-B_receptor stabilizes Niemann-Pick_type_C2_protein and regulates intracellular cholesterol trafficking .
12734548	0	Nijmegen_Breakage_Syndrome	53,79	NBS1	81,85	Nijmegen Breakage Syndrome	NBS1	4683	4683	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiplex single-tube screening for mutations in the Nijmegen_Breakage_Syndrome -LRB- NBS1 -RRB- gene in Hodgkin 's and non-Hodgkin 's _ lymphoma patients of Slavic origin .
18724061	0	Nijmegen_breakage_syndrome	0,26	NBS1	69,73	Nijmegen breakage syndrome	NBS1	4683	4683	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Nijmegen_breakage_syndrome and functions of the responsible protein , NBS1 .
24510842	0	Nijmegen_breakage_syndrome	30,56	NBS1	58,62	Nijmegen breakage syndrome	NBS1	4683	4683	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The prognostic impact of high Nijmegen_breakage_syndrome -LRB- NBS1 -RRB- gene expression in ERG-negative prostate_cancers lacking PTEN deletion is driven by KPNA2 expression .
7556088	0	NinaC	33,38	Calmodulin	0,10	NinaC	Calmodulin	34012(Tax:7227)	36329(Tax:7227)	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Calmodulin binding to Drosophila NinaC required for termination of phototransduction .
23665482	0	Ninein	20,26	NIN	28,31	Ninein	NIN	51199	51199	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Identification of a Ninein -LRB- NIN -RRB- mutation in a family with spondyloepimetaphyseal_dysplasia with joint_laxity -LRB- leptodactylic type -RRB- - like phenotype .
15464245	0	Ninjurin1	0,9	p21	20,23	Ninjurin1	p21	4814	1026	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells .
23690620	0	Ninjurin1	0,9	p53	23,26	Ninjurin1	p53	4814	7157	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Ninjurin1 , a target of p53 , regulates p53 expression and p53-dependent cell survival , senescence , and radiation-induced mortality .
23690620	0	Ninjurin1	0,9	p53	38,41	Ninjurin1	p53	4814	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Ninjurin1 , a target of p53 , regulates p53 expression and p53-dependent cell survival , senescence , and radiation-induced mortality .
10049778	0	Nip3	118,122	p53	126,129	Nip3	p53	12176(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Effects of wild-type and mutated p53 and Id proteins on the induction of apoptosis by adenovirus E1A , c-Myc , Bax , and Nip3 in p53 null mouse cerebellum cells .
9891085	0	Nip7p	0,5	Nop8p	21,26	Nip7p	Nop8p	855890(Tax:4932)	854021(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nip7p interacts with Nop8p , an essential nucleolar protein required for 60S ribosome biogenesis , and the exosome subunit Rrp43p .
15146186	0	Nipped-B	105,113	NIPBL	53,58	Nipped-B	NIPBL	3355136(Tax:7227)	25836	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Cornelia_de_Lange_syndrome is caused by mutations in NIPBL , the human homolog of Drosophila_melanogaster Nipped-B .
18392847	0	Nipsnap1	18,26	TRPV6	67,72	Nipsnap1	TRPV6	18082(Tax:10090)	64177(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity .
12868002	0	Nischarin	29,38	IRAS	0,4	Nischarin	IRAS	11188	11188	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	IRAS , the human homologue of Nischarin , prolongs survival of transfected PC12 cells .
18332102	0	Nischarin	0,9	LIM_kinase	19,29	Nischarin	LIM kinase	11188	3984	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nischarin inhibits LIM_kinase to regulate cofilin phosphorylation and cell invasion .
12915132	0	Nischarin	0,9	Rac	19,22	Nischarin	Rac	11188	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK .
14528910	0	Nit_protein_2	44,57	Mitofilin	100,109	Nit protein 2	Mitofilin	56954	10989	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Deranged hypothetical proteins Rik protein , Nit_protein_2 and mitochondrial_inner_membrane_protein , Mitofilin , in fetal Down syndrome brain .
17014963	0	Nitric-oxide_synthase	0,21	cytochrome_P450	25,40	Nitric-oxide synthase	cytochrome P450	4843	4051	Gene	Gene	START_ENTITY|dep|family family|amod|END_ENTITY	Nitric-oxide_synthase : a cytochrome_P450 family foster child .
18003616	0	Nitric-oxide_synthase_2	0,23	CD74	39,43	Nitric-oxide synthase 2	CD74	4843	972	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nitric-oxide_synthase_2 interacts with CD74 and inhibits its cleavage by caspase during dendritic cell development .
24713495	0	Nitric_oxide_synthase	0,21	NOS	23,26	Nitric oxide synthase	NOS	4842	4842	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Nitric_oxide_synthase -LRB- NOS -RRB- single nucleotide polymorphisms are associated with coronary_heart_disease and hypertension in the INTERGENE study .
9851535	0	Nitric_oxide_synthase	0,21	haem_oxygenase	36,50	Nitric oxide synthase	haem oxygenase	18126(Tax:10090)	15368(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Nitric_oxide_synthase inhibition by haem_oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity : a negative feedback mechanism for the regulation of nitric_oxide production .
15922861	0	Nitric_oxide_synthase_2	0,23	NOS2	25,29	Nitric oxide synthase 2	NOS2	4843	4843	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Nitric_oxide_synthase_2 -LRB- NOS2 -RRB- promoter polymorphisms in colorectal_cancer .
19363302	0	Nix	0,3	GABARAP	22,29	Nix	GABARAP	665	11337	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Nix directly binds to GABARAP : a possible crosstalk between apoptosis and autophagy .
26341558	0	Nkx2-1	30,36	Foxa2	0,5	Nkx2-1	Foxa2	7080	3170	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung_adenocarcinoma metastasis .
19853745	0	Nkx2-1	37,43	RET	30,33	Nkx2-1	RET	7080	5979	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of RET by Nkx2-1 , Phox2b , Sox10 , and Pax3 .
20188614	0	Nkx2-3	19,25	endothelin-1	78,90	Nkx2-3	endothelin-1	159296	1906	Gene	Gene	regulated|nmod|START_ENTITY Genes|acl|regulated Genes|dep|implication implication|nmod|END_ENTITY	Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells : implication of endothelin-1 in inflammatory_bowel_disease .
9612365	0	Nkx2-5	42,48	CSX	50,53	Nkx2-5	CSX	18091(Tax:10090)	18091(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of the cardiac homeobox gene Nkx2-5 -LRB- CSX -RRB- in feline right ventricular pressure overload .
12824294	0	Nkx2-5	99,105	Endothelin-converting_enzyme-1	0,30	Nkx2-5	Endothelin-converting enzyme-1	1482	1889	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- is a downstream target of the homeobox transcription factor Nkx2-5 .
21464046	0	Nkx2-5	0,6	Gata1	17,22	Nkx2-5	Gata1	1482	2623	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis .
23751912	0	Nkx2-5	50,56	Lrrc10	0,6	Nkx2-5	Lrrc10	18091(Tax:10090)	237560(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4 .
21931855	0	Nkx2-5	58,64	SUMO-1	8,14	Nkx2-5	SUMO-1	1482	7341	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5 .
14550786	0	Nkx2-5	51,57	Tbx20	21,26	Nkx2-5	Tbx20	18091(Tax:10090)	57246(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cardiac T-box factor Tbx20 directly interacts with Nkx2-5 , GATA4 , and GATA5 in regulation of gene expression in the developing heart .
11431700	0	Nkx2-5	21,27	Tbx5	0,4	Nkx2-5	Tbx5	18091(Tax:10090)	21388(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation .
24069547	0	Nkx2-5	0,6	Tdgf1	17,22	Nkx2-5	Tdgf1	1482	6997	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|xcomp|END_ENTITY	Nkx2-5 Regulates Tdgf1 -LRB- Cripto -RRB- Early During Cardiac Development .
19366374	0	Nkx2-5	83,89	Tolloid-like_1	14,28	Nkx2-5	Tolloid-like 1	1482	7092	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|compound|END_ENTITY	Activation of Tolloid-like_1 gene expression by the cardiac specific homeobox gene Nkx2-5 .
21930795	0	Nkx2-5	21,27	atrial_natriuretic_factor	49,74	Nkx2-5	atrial natriuretic factor	18091(Tax:10090)	230899(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|compound|END_ENTITY	Differential role of Nkx2-5 in activation of the atrial_natriuretic_factor gene in the developing versus failing heart .
19509300	0	Nlp	41,44	BRCA1	0,5	Nlp	BRCA1	22981	672	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	BRCA1 interaction of centrosomal protein Nlp is required for successful mitotic progression .
26602597	0	Nlrp3	29,34	GPRC6A	0,6	Nlrp3	GPRC6A	216799(Tax:10090)	210198(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	GPRC6A mediates Alum-induced Nlrp3 inflammasome activation but limits Th2 type antibody responses .
22100755	0	Nlrp3	80,85	IL-1b	39,44	Nlrp3	IL-1b	114548	3553	Gene	Gene	activation|amod|START_ENTITY trigger|nmod|activation trigger|dobj|release release|compound|END_ENTITY	Double-walled carbon nanotubes trigger IL-1b release in human monocytes through Nlrp3 inflammasome activation .
23376234	0	Nlrp3	36,41	IL-1b	65,70	Nlrp3	IL-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1b secretion in association with alterations in cellular redox and energy status .
22848083	0	Nlrp3	4,9	interleukin-1b	92,106	Nlrp3	interleukin-1b	216799(Tax:10090)	16176(Tax:10090)	Gene	Gene	inflammasome|amod|START_ENTITY promotes|nsubj|inflammasome promotes|advcl|END_ENTITY	The Nlrp3 inflammasome promotes myocardial_dysfunction in structural cardiomyopathy through interleukin-1b .
24915993	0	Nm23	20,24	VHL	50,53	Nm23	VHL	4830	7428	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between Nm23 and the tumor suppressor VHL .
21559562	0	Nm23	0,4	nm23	67,71	Nm23	nm23	4830	4830	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Nm23 expression in human gastric_cancers - possible correlation of nm23 with lymph-node metastasis .
1659843	0	Nm23	49,53	nucleoside_diphosphate_kinase	18,47	Nm23	nucleoside diphosphate kinase	4830	129607	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of nucleoside_diphosphate_kinase -LRB- Nm23 -RRB- in solid tumours .
12669312	0	Nm23-H1	53,60	P53	0,3	Nm23-H1	P53	4830	7157	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	P53 is a regulator of the metastasis suppressor gene Nm23-H1 .
23940300	0	Nm23-h1	0,7	gelsolin	17,25	Nm23-h1	gelsolin	4830	2934	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis .
16964444	0	Nmf11	0,5	glycine_receptor_alpha_1_subunit	51,83	Nmf11	glycine receptor alpha 1 subunit	14654(Tax:10090)	14654(Tax:10090)	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|END_ENTITY	Nmf11 is a novel ENU-induced mutation in the mouse glycine_receptor_alpha_1_subunit .
25088258	0	Nmi	0,3	Hsp105b	19,26	Nmi	Hsp105b	9111	10808	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nmi interacts with Hsp105b and enhances the Hsp105b-mediated Hsp70 expression .
9989503	0	Nmi	26,29	IL-2	54,58	Nmi	IL-2	9111	3558	Gene	Gene	association|nmod|START_ENTITY association|nmod|signaling signaling|amod|END_ENTITY	Functional association of Nmi with Stat5 and Stat1 in IL-2 - and IFNgamma-mediated signaling .
22974759	0	Nmi	46,49	N-myc_and_STAT_interactor	19,44	Nmi	N-myc and STAT interactor	9111	9111;4613	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A critical role of N-myc_and_STAT_interactor -LRB- Nmi -RRB- in foot-and-mouth_disease virus -LRB- FMDV -RRB- 2C-induced apoptosis .
9989503	0	Nmi	26,29	Stat5	35,40	Nmi	Stat5	9111	6776	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Functional association of Nmi with Stat5 and Stat1 in IL-2 - and IFNgamma-mediated signaling .
10651151	0	Nociceptin	0,10	ORL1	92,96	Nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|rat rat|nmod|receptors receptors|compound|END_ENTITY	Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors .
9042395	0	Nociceptin	0,10	ORL1	60,64	Nociceptin	ORL1	5368	4987	Gene	Gene	START_ENTITY|dep|agonist agonist|nmod|like1 like1|appos|END_ENTITY	Nociceptin : an endogenous agonist for central opioid like1 -LRB- ORL1 -RRB- receptors possesses systemic vasorelaxant properties .
9096263	0	Nociceptin	0,10	ORL1	41,45	Nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|endogenous endogenous|acl|ligand ligand|nmod|receptor receptor|compound|END_ENTITY	Nociceptin , an endogenous ligand for the ORL1 receptor , has novel hypotensive activity in the rat .
9213368	0	Nociceptin	0,10	ORL1	41,45	Nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	ligand|advcl|START_ENTITY ligand|nmod|receptor receptor|compound|END_ENTITY	Nociceptin , an endogenous ligand for the ORL1 receptor , decreases_cardiac_output and total peripheral resistance in the rat .
9285926	0	Nociceptin	0,10	ORL1	41,45	Nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|endogenous endogenous|acl|ligand ligand|nmod|receptor receptor|compound|END_ENTITY	Nociceptin , an endogenous ligand for the ORL1 receptor , has vasodilator activity in the hindquarters vascular bed of the rat .
9384238	0	Nociceptin	0,10	ORL1	35,39	Nociceptin	ORL1	5368	4987	Gene	Gene	activation|compound|START_ENTITY activation|nmod|receptor receptor|compound|END_ENTITY	Nociceptin activation of the human ORL1 receptor expressed in Chinese_hamster ovary cells : functional homology with opioid receptors .
9879748	0	Nociceptin	0,10	ORL1	46,50	Nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|endogenous endogenous|acl|ligand ligand|nmod|receptor receptor|compound|END_ENTITY	Nociceptin , a novel endogenous ligand for the ORL1 receptor , dilates isolated resistance arteries from the rat .
8930965	0	Nociceptin	0,10	orphanin_FQ	70,81	Nociceptin	orphanin FQ	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Nociceptin or antinociceptin : potent spinal antinociceptive effect of orphanin_FQ / nociceptin in the rat .
20685873	0	Nocturnin	0,9	igf1	21,25	Nocturnin	igf1	12457(Tax:10090)	16000(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Nocturnin suppresses igf1 expression in bone by targeting the 3 ' untranslated region of igf1 mRNA .
27061450	0	Nod-like_Receptor_Protein_3	45,72	NLRP3	74,79	Nod-like Receptor Protein 3	NLRP3	287362(Tax:10116)	287362(Tax:10116)	Gene	Gene	Activation|compound|START_ENTITY Activation|appos|END_ENTITY	Agmatine Reverses Sub-Chronic Stress-induced Nod-like_Receptor_Protein_3 -LRB- NLRP3 -RRB- Activation and Cytokine Response in Rats .
12775719	0	Nod1	49,53	NF-kappa_B	24,34	Nod1	NF-kappa B	10392	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	CARD6 is a modulator of NF-kappa_B activation by Nod1 - and Cardiak-mediated pathways .
20519512	0	Nod1	87,91	nucleotide-binding_oligomerization_domain_protein_1	34,85	Nod1	nucleotide-binding oligomerization domain protein 1	10392	10392	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of natural human nucleotide-binding_oligomerization_domain_protein_1 -LRB- Nod1 -RRB- ligands from bacterial culture supernatant for elucidation of immune modulators in the environment .
16552041	0	Nod2	69,73	NF-kappa_B-inducing_kinase	0,26	Nod2	NF-kappa B-inducing kinase	257632(Tax:10090)	53859(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappa_B-inducing_kinase regulates selected gene expression in the Nod2 signaling pathway .
25429073	0	Nod2	25,29	NOD2	72,76	Nod2	NOD2	257632(Tax:10090)	257632(Tax:10090)	Gene	Gene	START_ENTITY|dobj|Expression Expression|nmod|END_ENTITY	Blau Syndrome-Associated Nod2 Mutation Alters Expression of Full-Length NOD2 and Limits Responses to Muramyl_Dipeptide in Knock-in Mice .
16714539	0	Nod2	42,46	erbin	9,14	Nod2	erbin	64127	55914	Gene	Gene	activation|nmod|START_ENTITY Role|nmod|activation Role|nmod|END_ENTITY	Role for erbin in bacterial activation of Nod2 .
23986775	0	Nodal	9,14	NODAL	33,38	Nodal	NODAL	4838	4838	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Maternal Nodal inversely affects NODAL and STOX1 expression in the fetal placenta .
23977305	0	Noggin	57,63	BMP-2	92,97	Noggin	BMP-2	9241	650	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	Enhanced osteogenesis of adipose derived stem cells with Noggin suppression and delivery of BMP-2 .
17359964	0	Noggin	0,6	Bmp4	17,21	Noggin	Bmp4	18121(Tax:10090)	12159(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Noggin regulates Bmp4 activity during pituitary induction .
24514266	0	Noggin	27,33	Follistatin	0,11	Noggin	Follistatin	9241	10468	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Follistatin interacts with Noggin in the development of the axial skeleton .
10223719	0	Noggin	0,6	Fos	19,22	Noggin	Fos	9241	2353	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Noggin upregulates Fos expression by a calcium-mediated pathway in amphibian embryos .
22503063	0	Noggin	26,32	NOG	34,37	Noggin	NOG	9241	9241	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the Noggin -LRB- NOG -RRB- gene in holoprosencephaly patients .
11869287	0	Noggin	42,48	Sox9	65,69	Noggin	Sox9	18121(Tax:10090)	20682(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The bone morphogenetic protein antagonist Noggin is regulated by Sox9 during endochondral differentiation .
12691732	0	Nogo	0,4	Reticulon_4	6,17	Nogo	Reticulon 4	68585(Tax:10090)	68585(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nogo -LRB- Reticulon_4 -RRB- expression in innervated and denervated mouse skeletal muscle .
12089450	0	Nogo-66_receptor	62,78	Myelin-associated_glycoprotein	0,30	Nogo-66 receptor	Myelin-associated glycoprotein	65078	4099	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Myelin-associated_glycoprotein as a functional ligand for the Nogo-66_receptor .
15930377	0	Nogo-66_receptor	26,42	Nogo-A	0,6	Nogo-66 receptor	Nogo-A	65078	57142	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nogo-A interacts with the Nogo-66_receptor through multiple sites to create an isoform-selective subnanomolar agonist .
15532024	0	Nogo-66_receptor	17,33	RTN4R	35,40	Nogo-66 receptor	RTN4R	65078	65078	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations of the Nogo-66_receptor -LRB- RTN4R -RRB- gene in schizophrenia .
14592966	0	Nogo-A	0,6	Caspr	39,44	Nogo-A	Caspr	83765(Tax:10116)	84008(Tax:10116)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Nogo-A at CNS paranodes is a ligand of Caspr : possible regulation of K -LRB- + -RRB- channel localization .
22943805	0	Nogo-A	15,21	NgR	23,26	Nogo-A	NgR	83765(Tax:10116)	113912(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Expression of Nogo-A , NgR mRNA and protein in the retina of rats with chronic elevated_intraocular_pressure -RSB- .
15930377	0	Nogo-A	0,6	Nogo-66_receptor	26,42	Nogo-A	Nogo-66 receptor	57142	65078	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nogo-A interacts with the Nogo-66_receptor through multiple sites to create an isoform-selective subnanomolar agonist .
26487844	0	Nogo-A	0,6	Nogo-A	77,83	Nogo-A	Nogo-A	57142	57142	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Nogo-A and its functions beyond axonal inhibition : the controversial role of Nogo-A in Parkinson 's disease .
26487844	0	Nogo-A	77,83	Nogo-A	0,6	Nogo-A	Nogo-A	57142	57142	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Nogo-A and its functions beyond axonal inhibition : the controversial role of Nogo-A in Parkinson 's disease .
19901030	0	Nogo-A	60,66	Nogo_receptor	8,21	Nogo-A	Nogo receptor	57142	65078	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Soluble Nogo_receptor down-regulates expression of neuronal Nogo-A to enhance axonal regeneration .
16095439	0	Nogo-B	0,6	MAPKAP-K2	44,53	Nogo-B	MAPKAP-K2	57142	9261	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Nogo-B is a new physiological substrate for MAPKAP-K2 .
19723497	0	Nogo-B_receptor	0,15	Niemann-Pick_type_C2_protein	27,55	Nogo-B receptor	Niemann-Pick type C2 protein	116150	10577	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Nogo-B_receptor stabilizes Niemann-Pick_type_C2_protein and regulates intracellular cholesterol trafficking .
24453941	0	Nogo-a	50,56	S1PR2	26,31	Nogo-a	S1PR2	68585(Tax:10090)	14739(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity .
12160746	0	Nogo66_receptor	50,65	Myelin-associated_glycoprotein	0,30	Nogo66 receptor	Myelin-associated glycoprotein	65078	4099	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Myelin-associated_glycoprotein interacts with the Nogo66_receptor to inhibit neurite outgrowth .
19901030	0	Nogo_receptor	8,21	Nogo-A	60,66	Nogo receptor	Nogo-A	65078	57142	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Soluble Nogo_receptor down-regulates expression of neuronal Nogo-A to enhance axonal regeneration .
12422217	0	Nogo_receptor	23,36	P75	0,3	Nogo receptor	P75	65079(Tax:10090)	18053(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	P75 interacts with the Nogo_receptor as a co-receptor for Nogo , MAG and OMgp .
25135490	0	Non-Structural_protein_1	0,24	NS1	26,29	Non-Structural protein 1	NS1	956024(Tax:329639)	956024(Tax:329639)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Non-Structural_protein_1 -LRB- NS1 -RRB- gene of Canine_Parvovirus-2 regresses chemically induced skin_tumors in Wistar_rats .
17277102	0	Non-T_cell_activation_linker	0,28	TREM-1	57,63	Non-T cell activation linker	TREM-1	7462	54210	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Non-T_cell_activation_linker -LRB- NTAL -RRB- negatively regulates TREM-1 / DAP12-induced inflammatory cytokine production in myeloid cells .
15493875	0	Non-muscle_alpha-actinin-4	0,26	plasminogen_activator_inhibitor_type-1	42,80	Non-muscle alpha-actinin-4	plasminogen activator inhibitor type-1	81	5054	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Non-muscle_alpha-actinin-4 interacts with plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- .
18801729	0	Nonsteroidal_anti-inflammatory_drug-activated_gene	0,50	GDF15	58,63	Nonsteroidal anti-inflammatory drug-activated gene	GDF15	9518	9518	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nonsteroidal_anti-inflammatory_drug-activated_gene -LRB- NAG-1 / GDF15 -RRB- expression is increased by the histone deacetylase inhibitor trichostatin_A .
23405236	0	Nonstructural_protein_1	0,23	guanylate-binding_protein_1	66,93	Nonstructural protein 1	guanylate-binding protein 1	10625	2633	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nonstructural_protein_1 of influenza_A_virus interacts with human guanylate-binding_protein_1 to antagonize antiviral activity .
21941128	0	Nop19p	22,28	Utp25p	59,65	Nop19p	Utp25p	853166(Tax:4932)	854717(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces_cerevisiae .
10341208	0	Nop52	22,27	RRP1	87,91	Nop52	RRP1	8568	851660(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The nucleolar antigen Nop52 , the human homologue of the yeast ribosomal RNA processing RRP1 , is recruited at late stages of nucleologenesis .
9891085	0	Nop8p	21,26	Nip7p	0,5	Nop8p	Nip7p	854021(Tax:4932)	855890(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nip7p interacts with Nop8p , an essential nucleolar protein required for 60S ribosome biogenesis , and the exosome subunit Rrp43p .
12401556	0	Norepinephrine_transporter	0,26	NET	33,36	Norepinephrine transporter	NET	6530	6530	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Norepinephrine_transporter gene -LRB- NET -RRB- variants in patients with panic_disorder .
15722184	0	Norepinephrine_transporter	0,26	NET	28,31	Norepinephrine transporter	NET	6530	6530	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Norepinephrine_transporter -LRB- NET -RRB- promoter and 5 ' - UTR polymorphisms : association analysis in panic_disorder .
21127421	0	Norepinephrine_transporter	0,26	SLC6A2	33,39	Norepinephrine transporter	SLC6A2	6530	6530	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Norepinephrine_transporter gene -LRB- SLC6A2 -RRB- is involved with methylphenidate response in Korean children with attention_deficit_hyperactivity_disorder .
25413347	0	Nostrin	57,64	E-cadherin	79,89	Nostrin	E-cadherin	8673992(Tax:7227)	37386(Tax:7227)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in regulating E-cadherin in epithelial morphogenesis .
25829514	0	Nostrin	57,64	E-cadherin	86,96	Nostrin	E-cadherin	115677	999	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in the regulation of E-cadherin in epithelial morphogenesis .
12223465	0	Notch	59,64	CSL	89,92	Notch	CSL	31293(Tax:7227)	34881(Tax:7227)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Keeping a good pathway down : transcriptional repression of Notch pathway target genes by CSL proteins .
25597954	0	Notch	31,36	Chip	0,4	Notch	Chip	31293(Tax:7227)	37837(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Chip physically interacts with Notch and their stoichiometry is critical for Notch function in wing development and cell proliferation in Drosophila .
11564735	0	Notch	66,71	Deltex-1	8,16	Notch	Deltex-1	31293(Tax:7227)	1840	Gene	Gene	receptor|compound|START_ENTITY Role|nmod|receptor Role|nmod|END_ENTITY	Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor .
18809725	0	Notch	40,45	Ero1L	0,5	Notch	Ero1L	31293(Tax:7227)	38500(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Ero1L , a thiol oxidase , is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila_melanogaster .
12736207	0	Notch	41,46	GLD-1	82,87	Notch	GLD-1	176282(Tax:6239)	172532(Tax:6239)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Translational repression of a C. _ elegans Notch mRNA by the STAR/KH domain protein GLD-1 .
11741889	0	Notch	48,53	HERP1	0,5	Notch	HERP1	25496(Tax:10116)	155430(Tax:10116)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	HERP1 is a cell type-specific primary target of Notch .
25976178	0	Notch	72,77	Hypoxia_Inducible_Factor-1a	112,139	Notch	Hypoxia Inducible Factor-1a	25496(Tax:10116)	29560(Tax:10116)	Gene	Gene	Up-Regulation|compound|START_ENTITY Up-Regulation|nmod|END_ENTITY	Electroacupuncture Pretreatment Attenuates Cerebral_Ischemic_Injury via Notch Pathway-Mediated Up-Regulation of Hypoxia_Inducible_Factor-1a in Rats .
9244301	0	Notch	45,50	Kuzbanian	0,9	Notch	Kuzbanian	31293(Tax:7227)	34772(Tax:7227)	Gene	Gene	processing|nmod|START_ENTITY controls|dobj|processing controls|nsubj|END_ENTITY	Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis .
18050403	0	Notch	7,12	LIN-12	0,6	Notch	LIN-12	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|appos|signaling	LIN-12 / Notch signaling in C. _ elegans .
23483278	0	Notch	7,12	LIN-12	0,6	Notch	LIN-12	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	LIN-12 / Notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification .
24512688	0	Notch	21,26	LIN-12	14,20	Notch	LIN-12	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	A role of the LIN-12 / Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. _ elegans .
9442877	0	Notch	11,16	LIN-12	4,10	Notch	LIN-12	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	The LIN-12 / Notch signaling pathway and its regulation .
25220057	0	Notch	14,19	Lgl	0,3	Notch	Lgl	31293(Tax:7227)	33156(Tax:7227)	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	Lgl regulates Notch signaling via endocytosis , independently of the apical aPKC-Par6-Baz polarity complex .
11483961	0	Notch	37,42	Nicastrin	0,9	Notch	Nicastrin	176282(Tax:6239)	172905(Tax:6239)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Nicastrin binds to membrane-tethered Notch .
11782315	0	Notch	69,74	Nicastrin	0,9	Notch	Nicastrin	31293(Tax:7227)	42964(Tax:7227)	Gene	Gene	receptor|compound|START_ENTITY cleavage|nmod|receptor required|nmod|cleavage required|nsubjpass|END_ENTITY	Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor .
10349633	0	Notch	70,75	Presenilin	31,41	Notch	Presenilin	31293(Tax:7227)	40260(Tax:7227)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Drosophila Presenilin and its colocalization with Notch during development .
17215302	0	Notch	83,88	SEL-2	0,5	Notch	SEL-2	176282(Tax:6239)	175606(Tax:6239)	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	SEL-2 , the C. _ elegans neurobeachin/LRBA homolog , is a negative regulator of lin-12 / Notch activity and affects endosomal traffic in polarized epithelial cells .
25280943	0	Notch	30,35	TRAF6	0,5	Notch	TRAF6	31293(Tax:7227)	31746(Tax:7227)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	TRAF6 is a novel regulator of Notch signaling in Drosophila_melanogaster .
19793883	0	Notch	0,5	Wnt-4	16,21	Notch	Wnt-4	394367(Tax:8355)	54361	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros .
25157415	0	Notch	0,5	Yorkie	15,21	Notch	Yorkie	31293(Tax:7227)	37851(Tax:7227)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Notch inhibits Yorkie activity in Drosophila wing discs .
16881048	0	Notch	0,5	axin	22,26	Notch	axin	31293(Tax:7227)	43565(Tax:7227)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Notch synergizes with axin to regulate the activity of armadillo in Drosophila .
11486031	0	Notch	58,63	cyclin_D1	13,22	Notch	cyclin D1	25496(Tax:10116)	595	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Induction of cyclin_D1 transcription and CDK2 activity by Notch -LRB- ic -RRB- : implication for cell cycle disruption in transformation by Notch -LRB- ic -RRB- .
25552605	0	Notch	17,22	hecd-1	0,6	Notch	hecd-1	176282(Tax:6239)	177486(Tax:6239)	Gene	Gene	START_ENTITY|nsubj|Modulates Modulates|amod|END_ENTITY	hecd-1 Modulates Notch Activity in Caenorhabditis_elegans .
23483278	0	Notch	7,12	lag-1	23,28	Notch	lag-1	176282(Tax:6239)	177373(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	LIN-12 / Notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification .
17215302	0	Notch	83,88	lin-12	76,82	Notch	lin-12	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	SEL-2 , the C. _ elegans neurobeachin/LRBA homolog , is a negative regulator of lin-12 / Notch activity and affects endosomal traffic in polarized epithelial cells .
11784090	0	Notch	36,41	nicastrin	6,15	Notch	nicastrin	176282(Tax:6239)	172905(Tax:6239)	Gene	Gene	START_ENTITY|dep|functions functions|compound|END_ENTITY	APH-2 / nicastrin functions in LIN-12 / Notch signaling in the Caenorhabditis_elegans somatic gonad .
26550436	0	Notch-1	0,7	GAS5	72,76	Notch-1	GAS5	4851	60674	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Notch-1 promotes breast_cancer cells proliferation by regulating LncRNA GAS5 .
12065598	0	Notch-1	63,70	Hes-1	71,76	Notch-1	Hes-1	4851	3280	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	The human acid alpha-glucosidase gene is a novel target of the Notch-1 / Hes-1 signaling pathway .
19838210	0	Notch-1	0,7	IKKalpha	70,78	Notch-1	IKKalpha	4851	1147	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	Notch-1 activates estrogen_receptor-alpha-dependent transcription via IKKalpha in breast_cancer cells .
18449946	0	Notch-1	14,21	Jagged-1_and_Delta-1	47,67	Notch-1	Jagged-1 and Delta-1	25496(Tax:10116)	29146;84010	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression of Notch-1 receptor and its ligands Jagged-1_and_Delta-1 in amoeboid microglia in postnatal rat brain and murine_BV-2 cells .
11418662	0	Notch-1	6,13	NF-kappa_B	23,33	Notch-1	NF-kappa B	4851	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Human Notch-1 inhibits NF-kappa_B activity in the nucleus through a direct interaction involving a novel domain .
18593473	0	Notch-1	90,97	Reelin	0,6	Notch-1	Reelin	4851	5649	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1 .
26131100	0	Notch-1	85,92	SIRT3	0,5	Notch-1	SIRT3	4851	23410	Gene	Gene	down-regulation|nmod|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	SIRT3 inhibits cell proliferation in human gastric_cancer through down-regulation of Notch-1 .
20814569	0	Notch-1	13,20	TNF	0,3	Notch-1	TNF	4851	7124	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression : implications in duchenne_muscular_dystrophy .
22479394	0	Notch-1	66,73	c-Src	20,25	Notch-1	c-Src	4851	6714	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic_cancer cells .
19091404	0	Notch-1	0,7	cyclin_D1	93,102	Notch-1	cyclin D1	4851	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin_D1 , CDK2 and p21 in T-ALL cell lines .
26012256	0	Notch-1	110,117	miR-200b	145,153	Notch-1	miR-200b	4851	406984	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|END_ENTITY	Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung_cancer cells by inactivating of Notch-1 signaling and switching on miR-200b .
18359760	0	Notch-1	0,7	p53	80,83	Notch-1	p53	4851	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Notch-1 regulates transcription of the epidermal_growth_factor_receptor through p53 .
21743969	0	Notch-1	0,7	p53	29,32	Notch-1	p53	4851	7157	Gene	Gene	restoration|nummod|START_ENTITY restoration|compound|END_ENTITY	Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells .
12794108	0	Notch-regulated_ankyrin-repeat_protein	0,38	Notch1	48,54	Notch-regulated ankyrin-repeat protein	Notch1	67122(Tax:10090)	18128(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Notch-regulated_ankyrin-repeat_protein inhibits Notch1 signaling : multiple Notch1 signaling pathways involved in T cell development .
12794108	0	Notch-regulated_ankyrin-repeat_protein	0,38	Notch1	75,81	Notch-regulated ankyrin-repeat protein	Notch1	67122(Tax:10090)	18128(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|Notch1 Notch1|acl|signaling signaling|parataxis|signaling signaling|nsubj|END_ENTITY	Notch-regulated_ankyrin-repeat_protein inhibits Notch1 signaling : multiple Notch1 signaling pathways involved in T cell development .
20551051	0	Notch1	87,93	ADAM17	0,6	Notch1	ADAM17	4851	6868	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	ADAM17 regulates epidermal_growth_factor_receptor expression through the activation of Notch1 in non-small_cell_lung_cancer .
26850133	0	Notch1	26,32	Akt	8,11	Notch1	Akt	4851	207	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression inhibition|compound|END_ENTITY	Role of Akt inhibition on Notch1 expression in hepatocellular_carcinoma : potential role for dual targeted therapy .
26033182	0	Notch1	37,43	Alpha-synuclein	0,15	Notch1	Alpha-synuclein	4851	6622	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Alpha-synuclein negatively regulates Notch1 intracellular domain protein stability through promoting interaction with Fbw7 .
18193087	0	Notch1	77,83	BCR/ABL	43,50	Notch1	BCR/ABL	18128(Tax:10090)	110279;11350	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Overexpression/enhanced kinase activity of BCR/ABL and altered expression of Notch1 induced acute_leukemia in p210BCR/ABL transgenic_mice .
8643633	0	Notch1	28,34	CBF1	69,73	Notch1	CBF1	4851	3516	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element .
17878313	0	Notch1	0,6	Delta-like-1	21,33	Notch1	Delta-like-1	4851	28514	Gene	Gene	engagement|amod|START_ENTITY engagement|nmod|END_ENTITY	Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells .
19724883	0	Notch1	0,6	Delta-like-1	38,50	Notch1	Delta-like-1	4851	28514	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Notch1 induces enhanced expression of Delta-like-1 in the U251MG glioma cell line .
15082708	0	Notch1	5,11	Deltex1	24,31	Notch1	Deltex1	4851	1840	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	NB-3 / Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes .
22836445	0	Notch1	41,47	Dicer1	0,6	Notch1	Dicer1	18128(Tax:10090)	192119(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Dicer1 and MiR-9 are required for proper Notch1 signaling and the Bergmann glial phenotype in the developing mouse cerebellum .
17259973	0	Notch1	24,30	Dll4	0,4	Notch1	Dll4	18128(Tax:10090)	54485(Tax:10090)	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis .
20443831	0	Notch1	14,20	ErbB2	0,5	Notch1	ErbB2	4851	2064	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	ErbB2 induces Notch1 activity and function in breast_cancer cells .
25587036	0	Notch1	0,6	Foxc2	16,21	Notch1	Foxc2	18128(Tax:10090)	14234(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium .
18550850	0	Notch1	0,6	Foxp3	43,48	Notch1	Foxp3	4851	50943	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells .
21389783	0	Notch1	71,77	Hes1	0,4	Notch1	Hes1	4851	3280	Gene	Gene	downstream|nmod|START_ENTITY downstream|nsubj|expression expression|amod|END_ENTITY	Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell_leukemia .
25624721	0	Notch1	82,88	Hes1	0,4	Notch1	Hes1	25496(Tax:10116)	29577(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Hes1 , an important gene for activation of hepatic stellate cells , is regulated by Notch1 and TGF-b/BMP signaling .
17526737	0	Notch1	32,38	Integrin-linked_kinase	0,22	Notch1	Integrin-linked kinase	4851	3611	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Integrin-linked_kinase controls Notch1 signaling by down-regulation of protein stability through Fbw7 ubiquitin ligase .
10934472	0	Notch1	70,76	Jagged1	32,39	Notch1	Jagged1	4851	182	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2 .
26249804	0	Notch1	52,58	Jagged1	0,7	Notch1	Jagged1	18128(Tax:10090)	16449(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Jagged1 intracellular domain-mediated inhibition of Notch1 signaling regulates cardiac homeostasis in the postnatal heart .
26249804	0	Notch1	52,58	Jagged1	0,7	Notch1	Jagged1	18128(Tax:10090)	16449(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Jagged1 intracellular domain-mediated inhibition of Notch1 signaling regulates cardiac homeostasis in the postnatal heart .
16245338	0	Notch1	0,6	Jagged2	23,30	Notch1	Jagged2	4851	3714	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud .
9315665	0	Notch1	96,102	Jagged2	54,61	Notch1	Jagged2	4851	3714	Gene	Gene	receptor|amod|START_ENTITY ligand|nmod|receptor encoding|dobj|ligand gene|acl|encoding analysis|appos|gene analysis|nmod|cDNA cDNA|nmod|END_ENTITY	Isolation and functional analysis of a cDNA for human Jagged2 , a gene encoding a ligand for the Notch1 receptor .
25759215	0	Notch1	31,37	Lysyl_oxidase-like_2	0,20	Notch1	Lysyl oxidase-like 2	18128(Tax:10090)	94352(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Lysyl_oxidase-like_2 represses Notch1 expression in the skin to promote squamous_cell_carcinoma progression .
23252402	0	Notch1	38,44	MDM2	71,75	Notch1	MDM2	18128(Tax:10090)	17246(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway .
23974950	0	Notch1	105,111	MiR-146a	0,8	Notch1	MiR-146a	18128(Tax:10090)	387164(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264 .7 macrophage cells by inhibiting Notch1 .
26800097	0	Notch1	57,63	MiR-146a	0,8	Notch1	MiR-146a	4851	406938	Gene	Gene	pathway|amod|START_ENTITY inhibiting|dobj|pathway modulates|advcl|inhibiting modulates|nsubj|END_ENTITY	MiR-146a modulates macrophage polarization by inhibiting Notch1 pathway in RAW264 .7 macrophages .
22483937	0	Notch1	84,90	MiR-34a	0,7	Notch1	MiR-34a	18128(Tax:10090)	723848(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-34a inhibits lipopolysaccharide-induced inflammatory response through targeting Notch1 in murine macrophages .
22684560	0	Notch1	75,81	MicroRNA-34a	0,12	Notch1	MicroRNA-34a	4851	407040	Gene	Gene	down-regulation|nmod|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	MicroRNA-34a inhibits human brain_glioma cell growth by down-regulation of Notch1 .
23085450	0	Notch1	90,96	MicroRNA-34a	0,12	Notch1	MicroRNA-34a	4851	407040	Gene	Gene	adriamycin|nmod|START_ENTITY modulates|xcomp|adriamycin modulates|nsubj|END_ENTITY	MicroRNA-34a modulates chemosensitivity of breast_cancer cells to adriamycin by targeting Notch1 .
25783790	0	Notch1	91,97	MicroRNA-34a	0,12	Notch1	MicroRNA-34a	4851	407040	Gene	Gene	downregulating|dobj|START_ENTITY stem|advcl|downregulating suppresses|ccomp|stem suppresses|nsubj|END_ENTITY	MicroRNA-34a suppresses the breast_cancer stem cell-like characteristics by downregulating Notch1 pathway .
16751266	0	Notch1	9,15	Myc	0,3	Notch1	Myc	18128(Tax:10090)	17869(Tax:10090)	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary_tumorigenesis in mice .
21803744	0	Notch1	10,16	Myc	67,70	Notch1	Myc	18128(Tax:10090)	17869(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung_adenocarcinoma .
17172638	0	Notch1	43,49	Nedd4	29,34	Notch1	Nedd4	25496(Tax:10116)	25489(Tax:10116)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced_muscle_tension .
12794108	0	Notch1	48,54	Notch-regulated_ankyrin-repeat_protein	0,38	Notch1	Notch-regulated ankyrin-repeat protein	18128(Tax:10090)	67122(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Notch-regulated_ankyrin-repeat_protein inhibits Notch1 signaling : multiple Notch1 signaling pathways involved in T cell development .
12794108	0	Notch1	75,81	Notch-regulated_ankyrin-repeat_protein	0,38	Notch1	Notch-regulated ankyrin-repeat protein	18128(Tax:10090)	67122(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY signaling|parataxis|signaling Notch1|acl|signaling inhibits|dobj|Notch1 inhibits|nsubj|END_ENTITY	Notch-regulated_ankyrin-repeat_protein inhibits Notch1 signaling : multiple Notch1 signaling pathways involved in T cell development .
19567869	0	Notch1	61,67	Numb	0,4	Notch1	Numb	4851	8650	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Numb regulates post-endocytic trafficking and degradation of Notch1 .
21356309	0	Notch1	15,21	Numb	0,4	Notch1	Numb	18128(Tax:10090)	18222(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Numb regulates Notch1 , but not Notch3 , during myogenesis .
19151708	0	Notch1	31,37	Pin1	21,25	Notch1	Pin1	4851	5300	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer .
21880906	0	Notch1	82,88	Platelet-derived_growth_factor_B_chain	0,38	Notch1	Platelet-derived growth factor B chain	4851	5155	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Platelet-derived_growth_factor_B_chain is a novel target gene of cocaine-mediated Notch1 signaling : implications for HIV-associated neurological_disorders .
9153393	0	Notch1	29,35	Presenilin_1	0,12	Notch1	Presenilin 1	18128(Tax:10090)	19164(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Presenilin_1 is required for Notch1 and DII1 expression in the paraxial mesoderm .
11239004	0	Notch1	76,82	RBP-J	33,38	Notch1	RBP-J	18128(Tax:10090)	19664(Tax:10090)	Gene	Gene	RAMIC|compound|START_ENTITY repeats|nmod|RAMIC repeats|nsubj|regions regions|nmod|interact interact|amod|END_ENTITY	The N - and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription .
9374409	0	Notch1	54,60	RBP-J	15,20	Notch1	RBP-J	18128(Tax:10090)	19664(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives .
19953094	0	Notch1	0,6	RhoC	48,52	Notch1	RhoC	4851	389	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|contribution contribution|nmod|END_ENTITY	Notch1 regulates the functional contribution of RhoC to cervical_carcinoma progression .
24684482	0	Notch1	0,6	Snail	17,22	Notch1	Snail	4851	6615	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Notch1 increases Snail expression under high reactive oxygen species conditions in hepatocellular_carcinoma cells .
22888005	0	Notch1	15,21	Wnt5a	0,5	Notch1	Wnt5a	4851	7474	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein .
26522984	0	Notch1	70,76	Zmiz1	26,31	Notch1	Zmiz1	4851	57178	Gene	Gene	Cofactor|nmod|START_ENTITY Cofactor|nsubj|END_ENTITY	The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia .
12960155	0	Notch1	0,6	amyloid_precursor_protein	25,50	Notch1	amyloid precursor protein	4851	351	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Notch1 competes with the amyloid_precursor_protein for gamma-secretase and down-regulates presenilin-1 gene expression .
20337085	0	Notch1	53,59	epidermal_growth_factor_receptor	133,165	Notch1	epidermal growth factor receptor	4851	1956	Gene	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study on the effects of overexpression of exogenous Notch1 in tongue_squamous_cell_carcinoma cells on cell growth and expression of epidermal_growth_factor_receptor in vitro -RSB- .
26361419	0	Notch1	0,6	interleukin-24	36,50	Notch1	interleukin-24	4851	11009	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular_carcinoma cells .
16651424	0	Notch1	22,28	mammalian_target_of_rapamycin	30,59	Notch1	mammalian target of rapamycin	4851	2475	Gene	Gene	signaling|nmod|START_ENTITY signaling|dep|END_ENTITY	Survival signaling by Notch1 : mammalian_target_of_rapamycin -LRB- mTOR -RRB- - dependent inhibition of p53 .
24492617	0	Notch1	27,33	membrane_type_1_matrix_metalloproteinase	45,85	Notch1	membrane type 1 matrix metalloproteinase	4851	4323	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Noncanonical activation of Notch1 protein by membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- controls melanoma cell proliferation .
22684561	0	Notch1	120,126	microRNA-34a	22,34	Notch1	microRNA-34a	4851	407040	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial_bladder_carcinoma by targeting Notch1 .
24765202	0	Notch1	71,77	microRNA-34a	17,29	Notch1	microRNA-34a	4851	407040	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Tumor suppressor microRNA-34a inhibits cell proliferation by targeting Notch1 in renal_cell_carcinoma .
12682059	0	Notch1	32,38	numb	10,14	Notch1	numb	4851	8650	Gene	Gene	ubiquitination|compound|START_ENTITY promote|dobj|ubiquitination promote|nsubj|proteins proteins|amod|END_ENTITY	Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain .
12682059	0	Notch1	86,92	numb	10,14	Notch1	numb	4851	8650	Gene	Gene	domain|amod|START_ENTITY ubiquitination|nmod|domain promote|dobj|ubiquitination promote|nsubj|proteins proteins|amod|END_ENTITY	Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain .
14991602	0	Notch1	21,27	p53	0,3	Notch1	p53	18128(Tax:10090)	22059(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	p53 regulates thymic Notch1 activation .
16651424	0	Notch1	22,28	p53	91,94	Notch1	p53	4851	7157	Gene	Gene	signaling|nmod|START_ENTITY signaling|dep|inhibition inhibition|nmod|END_ENTITY	Survival signaling by Notch1 : mammalian_target_of_rapamycin -LRB- mTOR -RRB- - dependent inhibition of p53 .
17186020	0	Notch1	10,16	p53	32,35	Notch1	p53	4851	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Activated Notch1 interacts with p53 to inhibit its phosphorylation and transactivation .
17237812	0	Notch1	90,96	p53	0,3	Notch1	p53	18128(Tax:10090)	22060(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY inhibiting|dobj|activity maintains|advcl|inhibiting maintains|nsubj|homologue homologue|compound|END_ENTITY	p53 homologue , p51/p63 , maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity .
17344417	0	Notch1	0,6	p53	12,15	Notch1	p53	4851	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases .
17353266	0	Notch1	14,20	p53	40,43	Notch1	p53	4851	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of Notch1 gene expression by p53 in epithelial cells .
17534448	0	Notch1	87,93	p53	15,18	Notch1	p53	4851	7157	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|Restoration Restoration|nmod|expression expression|compound|END_ENTITY	Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1 : implications for cancer_cell_fate_determination after genotoxic stress .
18049480	0	Notch1	139,145	p53	214,217	Notch1	p53	4851	7157	Gene	Gene	effects|amod|START_ENTITY independent|nsubj|effects independent|nmod|END_ENTITY	Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53 .
19376776	0	Notch1	0,6	p53	174,177	Notch1	p53	4851	7157	Gene	Gene	signaling|compound|START_ENTITY sensitizes|nsubj|signaling sensitizes|advcl|inhibiting inhibiting|dobj|degradation degradation|compound|END_ENTITY	Notch1 signaling sensitizes tumor_necrosis_factor-related_apoptosis-inducing_ligand-induced apoptosis in human hepatocellular_carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression .
21480340	0	Notch1	0,6	p53	56,59	Notch1	p53	4851	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|overexpression overexpression|compound|END_ENTITY	Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular_carcinoma .
23943799	0	Notch1	0,6	p53	93,96	Notch1	p53	4851	7157	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|lung_adenocarcinoma lung_adenocarcinoma|nmod|END_ENTITY	Notch1 is required for Kras-induced lung_adenocarcinoma and controls_tumor cell survival via p53 .
11986231	0	Notch2	0,6	CD23	44,48	Notch2	CD23	4853	2208	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|overexpression overexpression|nmod|END_ENTITY	Notch2 is involved in the overexpression of CD23 in B-cell_chronic_lymphocytic_leukemia .
15621797	0	Notch2	33,39	CD23	14,18	Notch2	CD23	4853	2208	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of CD23 expression by Notch2 in B-cell_chronic_lymphocytic_leukemia .
10958687	0	Notch2	43,49	Delta1	11,17	Notch2	Delta1	4853	8788	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Delta1 , Jagged1 , and Jagged2 to Notch2 rapidly induces cleavage , nuclear translocation , and hyperphosphorylation of Notch2 .
22293205	0	Notch2	0,6	Fos	66,69	Notch2	Fos	4853	2353	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Notch2 regulates the development of marginal zone B cells through Fos .
23243020	0	Notch2	39,45	Midkine	0,7	Notch2	Midkine	4853	17242(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Midkine promotes neuroblastoma through Notch2 signaling .
23326131	0	Notch2	0,6	matrix_metallopeptidase_9	17,42	Notch2	matrix metallopeptidase 9	4853	4318	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Notch2 regulates matrix_metallopeptidase_9 via PI3K/AKT signaling in human gastric_carcinoma cell MKN-45 .
26868537	0	Notch3	110,116	HIF-2a	103,109	Notch3	HIF-2a	18131(Tax:10090)	13819(Tax:10090)	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	LPS causes pericyte loss and microvascular_dysfunction via disruption of Sirt3/angiopoietins/Tie -2 and HIF-2a / Notch3 pathways .
25356737	0	Notch3	71,77	WWP2	39,43	Notch3	WWP2	4854	11060	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian_Cancer .
11925448	0	Notch3	0,6	c-FLIP	57,63	Notch3	c-FLIP	4854	8837	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation .
26940787	0	Notch_1	61,68	Jagged_1	70,78	Notch 1	Jagged 1	18128(Tax:10090)	16449(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	DHA Suppresses Primary Macrophage Inflammatory Responses via Notch_1 / Jagged_1 Signaling .
25260616	0	Notch_1	14,21	THP-1	35,40	Notch 1	THP-1	4851	2736	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Regulation of Notch_1 signaling in THP-1 cells enhances M2 macrophage differentiation .
16175584	0	Notch_1	0,7	amyloid_precursor_protein	27,52	Notch 1	amyloid precursor protein	4851	351	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Notch_1 interacts with the amyloid_precursor_protein in a Numb-independent manner .
21402876	0	Notch_4	16,23	Mdm2	42,46	Notch 4	Mdm2	4855	4193	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Trp53 regulates Notch_4 signaling through Mdm2 .
21402876	0	Notch_4	16,23	Trp53	0,5	Notch 4	Trp53	4855	7157	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Trp53 regulates Notch_4 signaling through Mdm2 .
15246694	0	Notch_receptors	57,72	presenilin_1_and_2	16,34	Notch receptors	presenilin 1 and 2	4851	5663;5664	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of presenilin_1_and_2 and their relation to Notch_receptors and ligands in human embryonic/foetal _ central_nervous_system .
18289368	0	Nov	130,133	Ccn3	135,139	Nov	Ccn3	18133(Tax:10090)	18133(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Abnormal skeletal and cardiac development , cardiomyopathy , muscle_atrophy and cataracts in mice with a targeted disruption of the Nov -LRB- Ccn3 -RRB- gene .
11784037	0	Nova-1	47,53	pasilla	0,7	Nova-1	pasilla	4857	44258(Tax:7227)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	pasilla , the Drosophila homologue of the human Nova-1 and Nova-2 proteins , is required for normal secretion in the salivary gland .
25942184	0	Nox-4	77,82	MCP-1	83,88	Nox-4	MCP-1	50507	6347	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Abstract 73 : MicroRNA Regulates Hemangioendothelioma Growth by Targeting the Nox-4 / MCP-1 Pathway .
25942184	0	Nox-4	77,82	MCP-1	83,88	Nox-4	MCP-1	50507	6347	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Abstract 73 : MicroRNA Regulates Hemangioendothelioma Growth by Targeting the Nox-4 / MCP-1 Pathway .
22120521	0	Nox1	47,51	RGS2	0,4	Nox1	RGS2	27035	5997	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	RGS2 is a negative regulator of STAT3-mediated Nox1 expression .
16987002	0	Nox1	66,70	cyclin_D1	30,39	Nox1	cyclin D1	237038(Tax:10090)	12443(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Redox-dependent expression of cyclin_D1 and cell proliferation by Nox1 in mouse lung epithelial cells .
22102727	0	Nox1	0,4	epidermal_growth_factor_receptor	24,56	Nox1	epidermal growth factor receptor	237038(Tax:10090)	13649(Tax:10090)	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	Nox1 transactivation of epidermal_growth_factor_receptor promotes N-cadherin shedding and smooth muscle cell migration .
15994299	0	Nox1	81,85	p22phox	46,53	Nox1	p22phox	27035	1535	Gene	Gene	generation|amod|START_ENTITY inhibitors|nmod|generation inhibitors|nsubj|mutations mutations|nmod|region region|nmod|END_ENTITY	Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1 - and Nox2-dependent reactive oxygen generation .
16894058	0	Nox2	0,4	Ca2	6,9	Nox2	Ca2	13058(Tax:10090)	12349(Tax:10090)	Gene	Gene	play|advmod|START_ENTITY play|nsubj|END_ENTITY	Nox2 , Ca2 + , and protein_kinase_C play a role in angiotensin_II-induced free radical production in nucleus tractus solitarius .
17869312	0	Nox2	104,108	NADPH_oxidase	89,102	Nox2	NADPH oxidase	1536	1536	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Implication of cytosolic_phospholipase_A2 -LRB- cPLA2 -RRB- in the regulation of human synoviocyte NADPH_oxidase -LRB- Nox2 -RRB- activity .
21042717	0	Nox2	29,33	NADPH_oxidase	14,27	Nox2	NADPH oxidase	1536	1536	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of NADPH_oxidase -LRB- Nox2 -RRB- by lipid rafts in breast_carcinoma cells .
23695780	0	Nox2	48,52	NADPH_oxidase	33,46	Nox2	NADPH oxidase	1536	1536	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Activation of apocynin-sensitive NADPH_oxidase -LRB- Nox2 -RRB- activity in INS-1 832/13 cells under glucotoxic conditions .
20708598	0	Nox2	66,70	Nox4	60,64	Nox2	Nox4	1536	50507	Gene	Gene	D-Loop|dep|START_ENTITY D-Loop|appos|END_ENTITY	Characterization of superoxide overproduction by the D-Loop -LRB- Nox4 -RRB- - Nox2 cytochrome b -LRB- 558 -RRB- in phagocytes-Differential sensitivity to calcium and phosphorylation events .
17803994	0	Nox2	50,54	p47phox	39,46	Nox2	p47phox	1536	653361	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	p40phox as an alternative organizer to p47phox in Nox2 activation : a new mechanism involving an interaction with p22phox .
26445208	1	Nox4	177,181	AT1	146,149	Nox4	AT1	50490(Tax:10090)	11607(Tax:10090)	Gene	Gene	Associates|nmod|START_ENTITY Associates|compound|END_ENTITY	AT1 Physically Associates With Nox4 .
22496405	0	Nox4	78,82	BMP-2	0,5	Nox4	BMP-2	50507	650	Gene	Gene	activation|amod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation .
21029048	0	Nox4	37,41	BMP2	50,54	Nox4	BMP2	50490(Tax:10090)	12156(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation .
18567639	0	Nox4	99,103	Insulin-like_growth_factor-I	0,28	Nox4	Insulin-like growth factor-I	85431(Tax:10116)	24482(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Insulin-like_growth_factor-I induces reactive_oxygen_species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells .
20708598	0	Nox4	60,64	Nox2	66,70	Nox4	Nox2	50507	1536	Gene	Gene	D-Loop|appos|START_ENTITY D-Loop|dep|END_ENTITY	Characterization of superoxide overproduction by the D-Loop -LRB- Nox4 -RRB- - Nox2 cytochrome b -LRB- 558 -RRB- in phagocytes-Differential sensitivity to calcium and phosphorylation events .
21443946	0	Nox4	142,146	Nrf2	0,4	Nox4	Nrf2	50507	4780	Gene	Gene	promoter|amod|START_ENTITY regulates|nmod|promoter regulates|nsubj|END_ENTITY	Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium : identification of functional antioxidant response elements on the Nox4 promoter .
21443946	0	Nox4	33,37	Nrf2	0,4	Nox4	Nrf2	50507	4780	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium : identification of functional antioxidant response elements on the Nox4 promoter .
21554947	0	Nox4	0,4	Nrf2	15,19	Nox4	Nrf2	50490(Tax:10090)	18024(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo .
24239742	0	Nox4	0,4	PTP1B	25,30	Nox4	PTP1B	50507	5770	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Nox4 redox regulation of PTP1B contributes to the proliferation and migration_of_glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C .
19574552	0	Nox4	30,34	Poldip2	0,7	Nox4	Poldip2	50507	26073	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Poldip2 , a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells .
21131394	0	Nox4	16,20	TGF-b	0,5	Nox4	TGF-b	50507	7040	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TGF-b regulates Nox4 , MnSOD and catalase expression , and IL-6 release in airway smooth muscle cells .
22728268	0	Nox4	0,4	TGF-beta	20,28	Nox4	TGF-beta	50507	7040	Gene	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells .
22791246	0	Nox4	30,34	histone_deacetylases	38,58	Nox4	histone deacetylases	50507	9734	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Nox4 by histone_deacetylases in human endothelial cells .
19540572	0	Nox4	0,4	plasminogen_activator_inhibitor-1	32,65	Nox4	plasminogen activator inhibitor-1	50507	5054	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Nox4 mediates the expression of plasminogen_activator_inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells .
22387196	0	Nox5	38,42	NADPH_oxidase_5	21,36	Nox5	NADPH oxidase 5	79400	79400	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Nitric_oxide reduces NADPH_oxidase_5 -LRB- Nox5 -RRB- activity by reversible S-nitrosylation .
20339118	0	Nox5	63,67	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5	0,61	Nox5	Nicotinamide adenine dinucleotide phosphate reduced oxidase 5	79400	79400	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5 -LRB- Nox5 -RRB- regulation by angiotensin_II and endothelin-1 is mediated via calcium/calmodulin-dependent , rac-1-independent pathways in human endothelial cells .
20339118	0	Nox5	63,67	angiotensin_II	83,97	Nox5	angiotensin II	79400	183	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5 -LRB- Nox5 -RRB- regulation by angiotensin_II and endothelin-1 is mediated via calcium/calmodulin-dependent , rac-1-independent pathways in human endothelial cells .
25975837	0	Noxa	79,83	Bax	112,115	Noxa	Bax	5366	581	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nmod|END_ENTITY	ALK-negative anaplastic_large_cell_lymphoma is sensitive to bortezomib through Noxa upregulation and release of Bax from Bcl-2 .
10807576	0	Noxa	0,4	Bcl-2	31,36	Noxa	Bcl-2	58801(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Noxa , a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis .
23429261	0	Noxa	50,54	Bcl-2	94,99	Noxa	Bcl-2	5366	596	Gene	Gene	induction|nmod|START_ENTITY effects|dep|induction effects|nmod|END_ENTITY	pRb/E2F -1 - mediated caspase-dependent induction of Noxa amplifies the apoptotic effects of the Bcl-2 / Bcl-xL inhibitor ABT-737 .
23593480	0	Noxa	27,31	JNK1	35,39	Noxa	JNK1	58801(Tax:10090)	26419(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors .
24525728	0	Noxa	0,4	MCL-1	46,51	Noxa	MCL-1	5366	4170	Gene	Gene	determines|nsubj|START_ENTITY determines|dobj|localization localization|nmod|sensitivity sensitivity|compound|END_ENTITY	Noxa determines localization and stability of MCL-1 and consequently ABT-737 sensitivity in small_cell_lung_cancer .
17703234	0	Noxa	77,81	Mcl-1	71,76	Noxa	Mcl-1	5366	4170	Gene	Gene	axis|compound|START_ENTITY Crosstalk|dep|axis Crosstalk|dep|acts acts|nmod|END_ENTITY	Crosstalk among Bcl-2 family members in B-CLL : seliciclib acts via the Mcl-1 / Noxa axis and gradual exhaustion of Bcl-2 protection .
19088028	0	Noxa	13,17	Mcl-1	70,75	Noxa	Mcl-1	5366	4170	Gene	Gene	Induction|nmod|START_ENTITY sensitizes|nsubj|Induction sensitizes|dobj|cells cells|acl|expressing expressing|xcomp|END_ENTITY	Induction of Noxa sensitizes human colorectal_cancer cells expressing Mcl-1 to the small-molecule Bcl-2 / Bcl-xL inhibitor , ABT-737 .
19936928	0	Noxa	119,123	Mcl-1	113,118	Noxa	Mcl-1	5366	4170	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1 / Noxa balance .
19946262	0	Noxa	147,151	Mcl-1	141,146	Noxa	Mcl-1	5366	4170	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1 / Noxa axis .
19946262	0	Noxa	147,151	Mcl-1	44,49	Noxa	Mcl-1	5366	4170	Gene	Gene	axis|compound|START_ENTITY activating|nmod|axis neutralizes|advcl|activating neutralizes|dobj|END_ENTITY	Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1 / Noxa axis .
21907705	0	Noxa	0,4	Mcl-1	29,34	Noxa	Mcl-1	5366	4170	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
21907705	0	Noxa	0,4	Mcl-1	80,85	Noxa	Mcl-1	5366	4170	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|regulation regulation|nmod|interaction interaction|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
23733106	0	Noxa	6,10	Mcl-1	61,66	Noxa	Mcl-1	58801(Tax:10090)	17210(Tax:10090)	Gene	Gene	uses|nsubj|START_ENTITY uses|nmod|END_ENTITY	Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1 .
22615771	0	Noxa	19,23	MiR-200c	0,8	Noxa	MiR-200c	5366	406985	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-200c regulates Noxa expression and sensitivity to proteasomal inhibitors .
21907705	0	Noxa	0,4	USP9X	86,91	Noxa	USP9X	5366	8239	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|regulation regulation|nmod|interaction interaction|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
23957209	0	Noxa1	73,78	Noxo1	19,24	Noxa1	Noxo1	10811	124056	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1 .
23957209	0	Noxo1	19,24	Noxa1	73,78	Noxo1	Noxa1	124056	10811	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1 .
25088421	0	Npas4	0,5	Mdm2	16,20	Npas4	Mdm2	266743	4193	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Npas4 regulates Mdm2 and thus Dcx in experience-dependent dendritic spine development of newborn olfactory bulb interneurons .
23020797	0	Npas4	58,63	neuronal_PAS_domain_4	35,56	Npas4	neuronal PAS domain 4	225872(Tax:10090)	225872(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional suppression of the neuronal_PAS_domain_4 -LRB- Npas4 -RRB- gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter .
20562239	0	Npc1	35,39	Apoe	26,30	Npc1	Apoe	18145(Tax:10090)	11816(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Reduced VLDL clearance in Apoe -LRB- - / - -RRB- Npc1 -LRB- - / - -RRB- mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels .
20053728	0	Npl3p	105,110	Hmt1p	33,38	Npl3p	Hmt1p	852042(Tax:4932)	852322(Tax:4932)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Yeast arginine methyltransferase Hmt1p regulates transcription elongation and termination by methylating Npl3p .
20137111	0	Npm1	26,30	FLT3	99,103	Npm1	FLT3	4869	2322	Gene	Gene	Correlation|nmod|START_ENTITY mutations|nsubj|Correlation mutations|nmod|mutation mutation|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Correlation of adult_AML Npm1 mutations with prognosis and its relationship with gene mutation of FLT3 and CEBPA -RSB- .
24991885	0	Npm1	50,54	Lrrc34	0,6	Npm1	Lrrc34	4869	151827	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	Lrrc34 , a Novel Nucleolar Protein , Interacts with Npm1 and Ncl and Has an Impact on Pluripotent Stem Cells .
27050906	0	Npm1	60,64	mTOR	0,4	Npm1	mTOR	4869	21977(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation .
17493133	0	Npr1	74,78	Mep2	37,41	Npr1	Mep2	855538(Tax:4932)	855580(Tax:4932)	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|appos|kinase	The yeast ammonium transport protein Mep2 and its positive regulator , the Npr1 kinase , play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium .
20154027	0	Npr2	0,4	NPRL2	50,55	Npr2	NPRL2	856647(Tax:4932)	10641	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Npr2 , yeast homolog of the human tumor suppressor NPRL2 , is a target of Grr1 required for adaptation to growth on diverse nitrogen sources .
15722353	0	Npr2	63,67	natriuretic_peptide_receptor_2	31,61	Npr2	natriuretic peptide receptor 2	230103(Tax:10090)	230103(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A loss-of-function mutation in natriuretic_peptide_receptor_2 -LRB- Npr2 -RRB- gene is responsible for disproportionate dwarfism in cn/cn mouse .
10873650	0	Npw38	7,12	dim1p	91,96	Npw38	dim1p	10084	10907	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PQBP-1 / Npw38 , a nuclear protein binding to the polyglutamine tract , interacts with U5-15kD / dim1p via the carboxyl-terminal domain .
19129404	0	Npy	26,29	A1/C1	62,67	Npy	A1/C1	4852	6966	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Simultaneous silencing of Npy and Dbh expression in hindbrain A1/C1 catecholamine cells suppresses glucoprivic feeding .
21821009	0	Nqo1	25,29	Nrf2	46,50	Nqo1	Nrf2	1728	4780	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe .
25772165	0	Nr0b1	0,5	Zscan4c	33,40	Nr0b1	Zscan4c	11614(Tax:10090)	245109(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells .
15689355	0	Nr2e3	44,49	Crx	65,68	Nr2e3	Crx	10002	1406	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes .
21468021	0	Nr4a2	28,33	Foxp3	42,47	Nr4a2	Foxp3	4929	50943	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4 + T cells .
20096661	0	Nr5a2	21,26	Oct4	39,43	Nr5a2	Oct4	26424(Tax:10090)	100846986	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells .
8922386	0	NrCAM	82,87	F11	97,100	NrCAM	F11	4897	2160	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites .
23251206	0	NrCAM	52,57	Neuronal_Cell_Adhesion_Molecule	19,50	NrCAM	Neuronal Cell Adhesion Molecule	4897	4897	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of the Neuronal_Cell_Adhesion_Molecule -LRB- NrCAM -RRB- Gene Variants with Personality Traits and Addictive Symptoms in Methamphetamine Use Disorder .
16251521	0	Nramp1	25,31	Slc11a1	16,23	Nramp1	Slc11a1	478909(Tax:9615)	478909(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism of Slc11a1 -LRB- Nramp1 -RRB- gene and canine leishmaniasis in a case-control study .
19116231	0	Nramp1	31,37	Slc11a1	13,20	Nramp1	Slc11a1	18173(Tax:10090)	18173(Tax:10090)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of Slc11a1 -LRB- formerly Nramp1 -RRB- on DSS-induced colitis in mice .
22508410	0	Nramp1	90,96	tumor_necrosis_factor-a	15,38	Nramp1	tumor necrosis factor-a	6556	7124	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	High levels of tumor_necrosis_factor-a downregulate antimicrobial iron transport protein , Nramp1 , in chronic hemodialysis patients : a key factor for infection risk .
25775092	0	Nrd1	108,112	Rrp6	88,92	Nrd1	Rrp6	4898	5394	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1 .
15175277	0	Nrf-1	61,66	FMR1	44,48	Nrf-1	FMR1	4899	2332	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Occupancy and synergistic activation of the FMR1 promoter by Nrf-1 and Sp1 in vivo .
18302760	0	Nrf-2	40,45	CD36	56,60	Nrf-2	CD36	18024(Tax:10090)	12491(Tax:10090)	Gene	Gene	dependent|amod|START_ENTITY up-regulation|amod|dependent up-regulation|compound|END_ENTITY	Rosiglitazone but not losartan prevents Nrf-2 dependent CD36 gene expression up-regulation in an in vivo atherosclerosis model .
21622902	0	Nrf-2	0,5	HO-1	40,44	Nrf-2	HO-1	4780	3162	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nrf-2 regulates cyclosporine-stimulated HO-1 expression in gingiva .
22484158	0	Nrf-2	140,145	HO-1	135,139	Nrf-2	HO-1	4780	3162	Gene	Gene	antioxidant|amod|START_ENTITY genes|amod|antioxidant genes|compound|END_ENTITY	Hepatoprotective effect of lucidone against alcohol-induced oxidative stress in human hepatic HepG2 cells through the up-regulation of HO-1 / Nrf-2 antioxidant genes .
23131562	0	Nrf-2	70,75	HO-1	76,80	Nrf-2	HO-1	4780	3162	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	Omega-3_polyunsaturated_fatty_acid has an anti-oxidant effect via the Nrf-2 / HO-1 pathway in 3T3-L1 adipocytes .
23311701	0	Nrf-2	72,77	HO-1	78,82	Nrf-2	HO-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2 / HO-1 pathway .
23816986	0	Nrf-2	23,28	HO-1	18,22	Nrf-2	HO-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY activation|parataxis|contributes activation|nmod|END_ENTITY	The activation of HO-1 / Nrf-2 contributes to the protective effects of diallyl_disulfide -LRB- DADS -RRB- against ethanol-induced oxidative stress .
24051194	0	Nrf-2	108,113	HO-1	114,118	Nrf-2	HO-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Diallyl-disulfide , an organosulfur compound of garlic , attenuates airway inflammation via activation of the Nrf-2 / HO-1 pathway and NF-kappaB suppression .
26525667	0	Nrf-2	109,114	HO-1	104,108	Nrf-2	HO-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|extra extra|nmod|model model|nmod|activation activation|nmod|END_ENTITY	Dietary extra virgin olive oil attenuates kidney_injury in pristane-induced SLE model via activation of HO-1 / Nrf-2 antioxidant pathway and suppression of JAK/STAT , NF-kB and MAPK activation .
9826775	0	Nrf1	0,4	fosB	23,27	Nrf1	fosB	18181(Tax:10090)	14282(Tax:10090)	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Nrf1 in a complex with fosB , c-jun , junD and ATF2 forms the AP1 component at the TNF_alpha promoter in stimulated mast cells .
20682644	0	Nrf2	43,47	ABCG2	14,19	Nrf2	ABCG2	4780	9429	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of ABCG2 -LRB- BCRP -RRB- is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype .
25058527	0	Nrf2	14,18	AICAR	0,5	Nrf2	AICAR	4780	471	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells .
24948812	0	Nrf2	0,4	ATP_binding_cassette_transporter	17,49	Nrf2	ATP binding cassette transporter	18024(Tax:10090)	76408(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Nrf2 upregulates ATP_binding_cassette_transporter expression and activity at the blood-brain and blood-spinal cord barriers .
23353771	0	Nrf2	0,4	BRCA1	78,83	Nrf2	BRCA1	4780	672	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|regulation regulation|nmod|activity activity|nmod|gene gene|compound|END_ENTITY	Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene .
23857982	0	Nrf2	21,25	BRCA1	0,5	Nrf2	BRCA1	18024(Tax:10090)	12189(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival .
16923960	0	Nrf2	20,24	BRG1	0,4	Nrf2	BRG1	4780	6597	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress .
23738048	0	Nrf2	18,22	Bach1	115,120	Nrf2	Bach1	4780	571	Gene	Gene	pathway|amod|START_ENTITY Activation|nmod|pathway Activation|nmod|END_ENTITY	Activation of the Nrf2 pathway by inorganic arsenic in human hepatocytes and the role of transcriptional repressor Bach1 .
22250088	0	Nrf2	29,33	CD4	37,40	Nrf2	CD4	4780	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Th2 skewing by activation of Nrf2 in CD4 -LRB- + -RRB- T cells .
25484350	0	Nrf2	4,8	CD4	68,71	Nrf2	CD4	4780	920	Gene	Gene	tBHQ|amod|START_ENTITY inhibits|nsubj|tBHQ inhibits|dobj|activation activation|nmod|cells cells|compound|END_ENTITY	The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells .
16374848	0	Nrf2	0,4	CYP2E1	21,27	Nrf2	CYP2E1	83619(Tax:10116)	25086(Tax:10116)	Gene	Gene	increased|nsubjpass|START_ENTITY increased|nmod|END_ENTITY	Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1 .
16551616	0	Nrf2	21,25	CYP2E1	55,61	Nrf2	CYP2E1	4780	1571	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic_acid-dependent toxicity .
19671018	0	Nrf2	0,4	CYP2E1	37,43	Nrf2	CYP2E1	18024(Tax:10090)	13106(Tax:10090)	Gene	Gene	defense|amod|START_ENTITY defense|nmod|END_ENTITY	Nrf2 and antioxidant defense against CYP2E1 toxicity .
23400918	0	Nrf2	0,4	CYP2E1	37,43	Nrf2	CYP2E1	83619(Tax:10116)	25086(Tax:10116)	Gene	Gene	defense|amod|START_ENTITY defense|nmod|END_ENTITY	Nrf2 and antioxidant defense against CYP2E1 toxicity .
17015834	0	Nrf2	120,124	DJ-1	0,4	Nrf2	DJ-1	4780	11315	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	DJ-1 , a cancer - _ and_Parkinson 's _ disease-associated protein , stabilizes the antioxidant transcriptional master regulator Nrf2 .
26643903	0	Nrf2	17,21	DJ-1	12,16	Nrf2	DJ-1	83619(Tax:10116)	117287(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	The role of DJ-1 / Nrf2 pathway in the pathogenesis of diabetic_nephropathy in rats .
25582778	0	Nrf2	39,43	EGFR	0,4	Nrf2	EGFR	18024(Tax:10090)	13649(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	EGFR mediates astragaloside_IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages .
21270272	0	Nrf2	27,31	ERK	45,48	Nrf2	ERK	18024(Tax:10090)	26413(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo .
20229611	0	Nrf2	48,52	Erythropoietin	0,14	Nrf2	Erythropoietin	4780	2056	Gene	Gene	translocation|nmod|START_ENTITY induces|dobj|translocation induces|nsubj|END_ENTITY	Erythropoietin induces nuclear translocation of Nrf2 and heme_oxygenase-1 expression in SH-SY5Y cells .
21852674	0	Nrf2	0,4	FGF21	15,20	Nrf2	FGF21	18024(Tax:10090)	56636(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Nrf2 represses FGF21 during long-term high-fat diet-induced obesity in mice .
21504366	0	Nrf2	0,4	FXR	67,70	Nrf2	FXR	4780	9971	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|competing competing|nmod|END_ENTITY	Nrf2 inhibits LXRa-dependent hepatic lipogenesis by competing with FXR for acetylase binding .
15923610	0	Nrf2	32,36	GI-GPx	4,10	Nrf2	GI-GPx	4780	2877	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	The GI-GPx gene is a target for Nrf2 .
26838164	0	Nrf2	21,25	GSK-3b	0,6	Nrf2	GSK-3b	83619(Tax:10116)	84027(Tax:10116)	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	GSK-3b downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral_ischemia-reperfusion .
18005231	0	Nrf2	50,54	GSK-3beta	0,9	Nrf2	GSK-3beta	4780	2932	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	GSK-3beta down-regulates the transcription factor Nrf2 after oxidant damage : relevance to exposure of neuronal cells to oxidative stress .
16794261	0	Nrf2	103,107	Glutathione_peroxidase_2	0,24	Nrf2	Glutathione peroxidase 2	18024(Tax:10090)	14776(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Glutathione_peroxidase_2 , the major cigarette smoke-inducible isoform of GPX in lungs , is regulated by Nrf2 .
16356129	0	Nrf2	100,104	HO-1	43,47	Nrf2	HO-1	4780	3162	Gene	Gene	enhancing|nmod|START_ENTITY enhancing|dobj|expression expression|compound|END_ENTITY	Molecular mechanisms involved in enhancing HO-1 expression : de-repression by heme and activation by Nrf2 , the `` one-two '' punch .
16923960	0	Nrf2	20,24	HO-1	48,52	Nrf2	HO-1	4780	3162	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|mediate mediate|dobj|induction induction|compound|END_ENTITY	BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress .
18404528	0	Nrf2	23,27	HO-1	56,60	Nrf2	HO-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|expression expression|compound|END_ENTITY	Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts .
19445907	0	Nrf2	42,46	HO-1	48,52	Nrf2	HO-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Curcumin upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
19590705	0	Nrf2	29,33	HO-1	45,49	Nrf2	HO-1	4780	3162	Gene	Gene	START_ENTITY|appos|Expression Expression|compound|END_ENTITY	Taurine_Chloramine Activates Nrf2 , Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen_Peroxide .
20227863	0	Nrf2	106,110	HO-1	13,17	Nrf2	HO-1	497024(Tax:9913)	513221(Tax:9913)	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products : a role for Nrf2 in vascular protection in diabetes .
21443188	0	Nrf2	74,78	HO-1	13,17	Nrf2	HO-1	4780	3162	Gene	Gene	regulation|nmod|START_ENTITY mediated|nmod|regulation mediated|nsubjpass|expression expression|compound|END_ENTITY	tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1 .
21443188	0	Nrf2	74,78	HO-1	139,143	Nrf2	HO-1	4780	3162	Gene	Gene	START_ENTITY|amod|binding binding|nmod|region region|nmod|END_ENTITY	tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1 .
23571756	0	Nrf2	0,4	HO-1	64,68	Nrf2	HO-1	4780	3162	Gene	Gene	activation|amod|START_ENTITY associated|nsubjpass|activation associated|nmod|formation formation|nmod|promoter promoter|compound|END_ENTITY	Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter .
24009858	0	Nrf2	90,94	HO-1	56,60	Nrf2	HO-1	4780	3162	Gene	Gene	Hemoxygenase-1|appos|START_ENTITY Hemoxygenase-1|appos|END_ENTITY	Finasteride Increases the Expression of Hemoxygenase-1 -LRB- HO-1 -RRB- and NF-E2-Related_Factor-2 -LRB- Nrf2 -RRB- Proteins in PC-3 Cells : Implication of Finasteride-Mediated High-Grade Prostate_Tumor Occurrence .
24252362	0	Nrf2	42,46	HO-1	48,52	Nrf2	HO-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Bicyclol upregulates transcription factor Nrf2 , HO-1 expression and protects rat brains against focal ischemia .
25014792	0	Nrf2	121,125	HO-1	39,43	Nrf2	HO-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	Nuclear_Factor_Erythroid_2-Related_Factor|appos|START_ENTITY Rescues|dep|Nuclear_Factor_Erythroid_2-Related_Factor Transfer|dep|Rescues Transfer|nmod|Heme_Oxygenase-1 Heme_Oxygenase-1|appos|END_ENTITY	Adoptive Transfer of Heme_Oxygenase-1 -LRB- HO-1 -RRB- - Modified Macrophages Rescues the Nuclear_Factor_Erythroid_2-Related_Factor -LRB- Nrf2 -RRB- Antiinflammatory Phenotype in Liver_Ischemia / Reperfusion Injury .
25107906	0	Nrf2	85,89	HO-1	26,30	Nrf2	HO-1	4780	3162	Gene	Gene	Distribution|nmod|START_ENTITY Modulates|dobj|Distribution Modulates|nsubj|Heme_Oxygenase-1 Heme_Oxygenase-1|appos|END_ENTITY	Nuclear Heme_Oxygenase-1 -LRB- HO-1 -RRB- Modulates Subcellular Distribution and Activation of Nrf2 , Impacting Metabolic and Anti-oxidant Defenses .
25213834	0	Nrf2	112,116	HO-1	33,37	Nrf2	HO-1	4780	3162	Gene	Gene	Development|nmod|START_ENTITY Development|nmod|Induction Induction|compound|END_ENTITY	Development of Refractoriness of HO-1 Induction to a Second Treatment with UVA Radiation and the Involvement of Nrf2 in Human Skin Fibroblasts .
19177192	0	Nrf2	94,98	Heme_Oxygenase-1	58,74	Nrf2	Heme Oxygenase-1	4780	3162	Gene	Gene	Activation|compound|START_ENTITY Induces|nmod|Activation Induces|dobj|Expression Expression|compound|END_ENTITY	Dimethoxycurcumin , a Synthetic Curcumin Analogue , Induces Heme_Oxygenase-1 Expression through Nrf2 Activation in RAW264 .7 Macrophages .
25014792	0	Nrf2	121,125	Heme_Oxygenase-1	21,37	Nrf2	Heme Oxygenase-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	Nuclear_Factor_Erythroid_2-Related_Factor|appos|START_ENTITY Rescues|dep|Nuclear_Factor_Erythroid_2-Related_Factor Transfer|dep|Rescues Transfer|nmod|END_ENTITY	Adoptive Transfer of Heme_Oxygenase-1 -LRB- HO-1 -RRB- - Modified Macrophages Rescues the Nuclear_Factor_Erythroid_2-Related_Factor -LRB- Nrf2 -RRB- Antiinflammatory Phenotype in Liver_Ischemia / Reperfusion Injury .
25107906	0	Nrf2	85,89	Heme_Oxygenase-1	8,24	Nrf2	Heme Oxygenase-1	4780	3162	Gene	Gene	Distribution|nmod|START_ENTITY Modulates|dobj|Distribution Modulates|nsubj|END_ENTITY	Nuclear Heme_Oxygenase-1 -LRB- HO-1 -RRB- Modulates Subcellular Distribution and Activation of Nrf2 , Impacting Metabolic and Anti-oxidant Defenses .
26505893	0	Nrf2	91,95	Heme_Oxygenase-1	121,137	Nrf2	Heme Oxygenase-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	Pathway|amod|START_ENTITY Pathway|nmod|END_ENTITY	Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells : Role of MAPKs on the Nrf2 Pathway and Induction of Heme_Oxygenase-1 .
26730678	0	Nrf2	8,12	Heme_Oxygenase-1	63,79	Nrf2	Heme Oxygenase-1	4780	3162	Gene	Gene	Coordinated|compound|START_ENTITY Coordinated|nmod|END_ENTITY	Diverse Nrf2 Activators Coordinated to Cobalt_Carbonyls Induce Heme_Oxygenase-1 and Release Carbon_Monoxide in Vitro and in Vivo .
12360409	0	Nrf2	0,4	INrf2	100,105	Nrf2	INrf2	4780	9817	Gene	Gene	degradation|amod|START_ENTITY inhibited|nsubjpass|degradation inhibited|nmod|END_ENTITY	Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132 , the human homolog to INrf2 .
12947090	0	Nrf2	105,109	INrf2	115,120	Nrf2	INrf2	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY leads|nmod|release leads|nmod|END_ENTITY	Phosphorylation of Nrf2 at Ser40 by protein_kinase_C in response to antioxidants leads to the release of Nrf2 from INrf2 , but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD -LRB- P -RRB- H : quinone_oxidoreductase-1 gene expression .
12947090	0	Nrf2	19,23	INrf2	115,120	Nrf2	INrf2	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY leads|nsubj|Phosphorylation leads|nmod|END_ENTITY	Phosphorylation of Nrf2 at Ser40 by protein_kinase_C in response to antioxidants leads to the release of Nrf2 from INrf2 , but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD -LRB- P -RRB- H : quinone_oxidoreductase-1 gene expression .
19666107	0	Nrf2	0,4	INrf2	5,10	Nrf2	INrf2	4780	9817	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Nrf2 : INrf2 -LRB- Keap1 -RRB- signaling in oxidative stress .
19920073	0	Nrf2	177,181	INrf2	36,41	Nrf2	INrf2	4780	9817	Gene	Gene	translocation|nmod|START_ENTITY required|nmod|translocation required|nsubjpass|modification modification|nmod|151 151|amod|END_ENTITY	Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance .
20864537	0	Nrf2	60,64	INrf2	23,28	Nrf2	INrf2	4780	9817	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|interaction interaction|nmod|END_ENTITY	Hsp90 interaction with INrf2 -LRB- Keap1 -RRB- mediates stress-induced Nrf2 activation .
22072718	0	Nrf2	13,17	INrf2	19,24	Nrf2	INrf2	4780	9817	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Inhibitor of Nrf2 -LRB- INrf2 or Keap1 -RRB- protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis .
22448038	0	Nrf2	153,157	INrf2	20,25	Nrf2	INrf2	4780	9817	Gene	Gene	activation|amod|START_ENTITY allow|dobj|activation controls|xcomp|allow tyrosine|ccomp|controls tyrosine|nsubj|END_ENTITY	Antioxidant-induced INrf2 -LRB- Keap1 -RRB- tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression .
25108015	0	Nrf2	13,17	INrf2	19,24	Nrf2	INrf2	4780	9817	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Inhibitor of Nrf2 -LRB- INrf2 or Keap1 -RRB- protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis .
25976679	0	Nrf2	80,84	INrf2	47,52	Nrf2	INrf2	4780	9817	Gene	Gene	Leads|nmod|START_ENTITY Leads|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Aromatase Inhibitor-Mediated Downregulation of INrf2 -LRB- Keap1 -RRB- Leads to Increased Nrf2 and Resistance in Breast_Cancer .
23788642	0	Nrf2	55,59	IQGAP1	39,45	Nrf2	IQGAP1	4780	8826	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase -LRB- ERK -RRB- kinase -LRB- MEK -RRB- - ERK pathway .
12145307	0	Nrf2	65,69	Keap1	4,9	Nrf2	Keap1	4780	9817	Gene	Gene	sequester|dobj|START_ENTITY required|xcomp|sequester required|nsubjpass|function function|compound|END_ENTITY	The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm .
12653965	0	Nrf2	70,74	Keap1	0,5	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	shuttling|nmod|START_ENTITY regulates|dobj|shuttling regulates|nsubj|END_ENTITY	Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles .
14585973	0	Nrf2	87,91	Keap1	30,35	Nrf2	Keap1	4780	9817	Gene	Gene	ubiquitination|nmod|START_ENTITY required|nmod|ubiquitination required|nsubjpass|residues residues|nmod|END_ENTITY	Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress .
14764898	0	Nrf2	72,76	Keap1	15,20	Nrf2	Keap1	4780	9817	Gene	Gene	function|nmod|START_ENTITY controls|dobj|function controls|nsubj|Scaffolding Scaffolding|nmod|END_ENTITY	Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes .
15282312	0	Nrf2	118,122	Keap1	24,29	Nrf2	Keap1	4780	9817	Gene	Gene	degradation|nmod|START_ENTITY regulate|dobj|degradation ligase|xcomp|regulate ligase|nsubj|functions functions|compound|END_ENTITY	Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 .
15601839	0	Nrf2	59,63	Keap1	12,17	Nrf2	Keap1	4780	9817	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin_3-Roc1 ligase .
15899855	0	Nrf2	53,57	Keap1	0,5	Nrf2	Keap1	4780	9817	Gene	Gene	shuttling|nmod|START_ENTITY regulates|dobj|shuttling regulates|nsubj|END_ENTITY	Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism .
16000310	0	Nrf2	0,4	Keap1	139,144	Nrf2	Keap1	4780	9817	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|pathway pathway|acl|involving involving|nmod|END_ENTITY	Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1 .
16006525	0	Nrf2	119,123	Keap1	63,68	Nrf2	Keap1	4780	9817	Gene	Gene	domain|amod|START_ENTITY binding|nmod|domain Neh2|amod|binding disrupt|dobj|Neh2 insufficient|xcomp|disrupt insufficient|nsubj|cysteines cysteines|nmod|protein protein|compound|END_ENTITY	Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2 .
16354693	0	Nrf2	46,50	Keap1	100,105	Nrf2	Keap1	4780	9817	Gene	Gene	activate|dobj|START_ENTITY activate|nmod|inhibition inhibition|nmod|activity activity|nmod|END_ENTITY	Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1 .
16449638	0	Nrf2	83,87	Keap1	91,96	Nrf2	Keap1	4780	9817	Gene	Gene	repression|nmod|START_ENTITY required|nmod|repression required|nmod|END_ENTITY	CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1 .
16785233	0	Nrf2	67,71	Keap1	74,79	Nrf2	Keap1	4780	9817	Gene	Gene	disrupting|dobj|START_ENTITY disrupting|dep|Maf Maf|dep|x x|dep|complex complex|dep|x x|dep|END_ENTITY	Arsenic induces NAD -LRB- P -RRB- H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer .
16888629	0	Nrf2	23,27	Keap1	17,22	Nrf2	Keap1	4780	9817	Gene	Gene	interface|compound|START_ENTITY interface|amod|END_ENTITY	Structure of the Keap1 : Nrf2 interface provides mechanistic insight into Nrf2 signaling .
16888629	0	Nrf2	72,76	Keap1	17,22	Nrf2	Keap1	4780	9817	Gene	Gene	provides|nmod|START_ENTITY provides|nsubj|Structure Structure|nmod|interface interface|amod|END_ENTITY	Structure of the Keap1 : Nrf2 interface provides mechanistic insight into Nrf2 signaling .
17127771	0	Nrf2	49,53	Keap1	95,100	Nrf2	Keap1	4780	9817	Gene	Gene	activate|dobj|START_ENTITY activate|nmod|association association|nmod|END_ENTITY	Novel n-3_fatty_acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3 .
17636022	0	Nrf2	113,117	Keap1	0,5	Nrf2	Keap1	4780	9817	Gene	Gene	export|nmod|START_ENTITY escorting|dobj|export controls|advcl|escorting controls|nsubj|END_ENTITY	Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 .
17822677	0	Nrf2	74,78	Keap1	14,19	Nrf2	Keap1	4780	9817	Gene	Gene	activity|amod|START_ENTITY repress|dobj|activity ability|acl|repress found|dobj|ability found|nsubj|mutation mutation|nmod|END_ENTITY	A mutation of Keap1 found in breast_cancer impairs its ability to repress Nrf2 activity .
18268004	0	Nrf2	81,85	Keap1	60,65	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY determining|dobj|activity cysteine|advcl|determining cysteine|dobj|residues residues|nmod|END_ENTITY	Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity .
18316592	0	Nrf2	33,37	Keap1	8,13	Nrf2	Keap1	4780	9817	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|Loss Loss|nmod|function function|amod|END_ENTITY	Loss of Keap1 function activates Nrf2 and provides advantages for lung_cancer cell growth .
18421157	0	Nrf2	46,50	Keap1	113,118	Nrf2	Keap1	4780	9817	Gene	Gene	modes|nmod|START_ENTITY insights|nmod|modes transcription|nsubj|insights transcription|nmod|END_ENTITY	Structural insights into the similar modes of Nrf2 transcription factor recognition by the cytoplasmic repressor Keap1 .
18692501	0	Nrf2	49,53	Keap1	22,27	Nrf2	Keap1	4780	9817	Gene	Gene	activation|amod|START_ENTITY confers|dobj|activation confers|nsubj|alteration alteration|nmod|END_ENTITY	Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder_cancer .
19386581	0	Nrf2	45,49	Keap1	119,124	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY activation|nmod|signaling Genetic|nmod|activation Genetic|dep|profiles profiles|nmod|knockout knockout|amod|END_ENTITY	Genetic versus chemoprotective activation of Nrf2 signaling : overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice .
19489739	0	Nrf2	14,18	Keap1	145,150	Nrf2	Keap1	4780	9817	Gene	Gene	ubiquitination|amod|START_ENTITY dependent|nsubj|ubiquitination dependent|nmod|volume volume|nmod|151 151|nmod|END_ENTITY	Cul3-mediated Nrf2 ubiquitination and antioxidant response element -LRB- ARE -RRB- activation are dependent on the partial molar volume at position 151 of Keap1 .
19666107	0	Nrf2	0,4	Keap1	12,17	Nrf2	Keap1	4780	9817	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|INrf2 INrf2|appos|END_ENTITY	Nrf2 : INrf2 -LRB- Keap1 -RRB- signaling in oxidative stress .
19952498	0	Nrf2	42,46	Keap1	106,111	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediated|dobj|activation mediated|nmod|END_ENTITY	Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1 .
20173742	0	Nrf2	91,95	Keap1	120,125	Nrf2	Keap1	4780	9817	Gene	Gene	transcription|dobj|START_ENTITY transcription|nmod|inactivation inactivation|nmod|END_ENTITY	The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 .
20175229	0	Nrf2	1,5	Keap1	44,49	Nrf2	Keap1	4780	9817	Gene	Gene	H460-N5|amod|START_ENTITY H460-N5|nmod|over-expression over-expression|amod|END_ENTITY	-LSB- Nrf2 down-regulated cell line H460-N5 with Keap1 over-expression increased sensitivity to anti-cancer drugs -RSB- .
20421418	0	Nrf2	28,32	Keap1	96,101	Nrf2	Keap1	4780	9817	Gene	Gene	activation|amod|START_ENTITY mechanism|nmod|activation mechanism|dep|interaction interaction|nmod|END_ENTITY	A noncanonical mechanism of Nrf2 activation by autophagy deficiency : direct interaction between Keap1 and p62 .
20486933	0	Nrf2	45,49	Keap1	104,109	Nrf2	Keap1	4780	9817	Gene	Gene	Identification|nmod|START_ENTITY inducers|nsubj|Identification inducers|dep|designed designed|xcomp|target target|dobj|region region|nmod|END_ENTITY	Identification and characterization of novel Nrf2 inducers designed to target the intervening region of Keap1 .
20498004	0	Nrf2	29,33	Keap1	64,69	Nrf2	Keap1	4780	9817	Gene	Gene	content|amod|START_ENTITY increases|dobj|content increases|advcl|downregulating downregulating|dobj|message message|amod|END_ENTITY	Benzo -LSB- a -RSB- pyrene increases the Nrf2 content by downregulating the Keap1 message .
20864537	0	Nrf2	60,64	Keap1	29,34	Nrf2	Keap1	4780	9817	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|interaction interaction|nmod|INrf2 INrf2|appos|END_ENTITY	Hsp90 interaction with INrf2 -LRB- Keap1 -RRB- mediates stress-induced Nrf2 activation .
21251164	0	Nrf2	36,40	Keap1	28,33	Nrf2	Keap1	4780	9817	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Molecular mechanisms of the Keap1 Nrf2 pathway in stress response and cancer evolution .
21651925	0	Nrf2	69,73	Keap1	42,47	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone , an electrophilic metabolite of butylated_hydroxyanisole .
21703357	0	Nrf2	23,27	Keap1	55,60	Nrf2	Keap1	83619(Tax:10116)	117519(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|S-nitrosylation S-nitrosylation|nmod|END_ENTITY	Nitric_oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells .
21799073	0	Nrf2	10,14	Keap1	40,45	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY Enhancing|dobj|pathway Enhancing|nmod|disruption disruption|nmod|END_ENTITY	Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis .
21920027	0	Nrf2	76,80	Keap1	111,116	Nrf2	Keap1	4780	9817	Gene	Gene	sequence|amod|START_ENTITY interaction|nmod|sequence analyses|nmod|interaction required|nsubj|analyses required|nmod|END_ENTITY	Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance .
21926171	0	Nrf2	19,23	Keap1	48,53	Nrf2	Keap1	4780	9817	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|advcl|targeting targeting|dobj|mRNA mRNA|amod|END_ENTITY	miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast_cancer cells .
22448038	0	Nrf2	153,157	Keap1	27,32	Nrf2	Keap1	4780	9817	Gene	Gene	activation|amod|START_ENTITY allow|dobj|activation controls|xcomp|allow tyrosine|ccomp|controls tyrosine|nsubj|INrf2 INrf2|appos|END_ENTITY	Antioxidant-induced INrf2 -LRB- Keap1 -RRB- tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression .
22743616	0	Nrf2	35,39	Keap1	0,5	Nrf2	Keap1	4780	9817	Gene	Gene	kills|dep|START_ENTITY END_ENTITY|parataxis|kills	Keap1 : one stone kills three birds Nrf2 , IKKb and Bcl-2 / Bcl-xL .
23274085	0	Nrf2	18,22	Keap1	76,81	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|advcl|promoting promoting|dobj|degradation degradation|nmod|END_ENTITY	Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver_damage .
23455180	0	Nrf2	33,37	Keap1	109,114	Nrf2	Keap1	4780	9817	Gene	Gene	pathway|amod|START_ENTITY study|nmod|pathway correlated|nsubj|study correlated|nmod|END_ENTITY	Immunohistochemical study of the Nrf2 pathway in colorectal_cancer : Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue .
23455180	0	Nrf2	68,72	Keap1	109,114	Nrf2	Keap1	4780	9817	Gene	Gene	expression|amod|START_ENTITY pathway|dep|expression study|nmod|pathway correlated|nsubj|study correlated|nmod|END_ENTITY	Immunohistochemical study of the Nrf2 pathway in colorectal_cancer : Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue .
23727018	0	Nrf2	27,31	Keap1	60,65	Nrf2	Keap1	4780	9817	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|deubiquitination deubiquitination|nmod|END_ENTITY	USP15 negatively regulates Nrf2 through deubiquitination of Keap1 .
24489685	0	Nrf2	72,76	Keap1	0,5	Nrf2	Keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY target|nmod|activation cysteine|nmod|target cysteine|nsubj|END_ENTITY	Keap1 cysteine 288 as a potential target for diallyl_trisulfide-induced Nrf2 activation .
24505412	0	Nrf2	35,39	Keap1	126,131	Nrf2	Keap1	4780	9817	Gene	Gene	Activation|nmod|START_ENTITY mediated|nsubjpass|Activation mediated|nmod|formation formation|nmod|dimers dimers|amod|END_ENTITY	Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers .
25049078	0	Nrf2	23,27	Keap1	49,54	Nrf2	Keap1	4780	9817	Gene	Gene	activation|amod|START_ENTITY controls|dobj|activation controls|nmod|END_ENTITY	MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis .
25301875	0	Nrf2	86,90	Keap1	28,33	Nrf2	Keap1	83619(Tax:10116)	117519(Tax:10116)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|modifications modifications|nmod|END_ENTITY	Epigenetic modifications of Keap1 regulate its interaction with the protective factor Nrf2 in the development of diabetic_retinopathy .
25307732	0	Nrf2	86,90	Keap1	55,60	Nrf2	Keap1	4780	9817	Gene	Gene	NF-E2-related_factor_2|appos|START_ENTITY isolated|nsubjpass|NF-E2-related_factor_2 Activation|parataxis|isolated Activation|nmod|Kelch-like_ECH-associated_protein_1 Kelch-like_ECH-associated_protein_1|appos|END_ENTITY	Activation of the Kelch-like_ECH-associated_protein_1 -LRB- Keap1 -RRB- / NF-E2-related_factor_2 -LRB- Nrf2 -RRB- pathway through covalent modification of the 2-alkenal group of aliphatic electrophiles in Coriandrum sativum L. Phytochemicals able to activate the transcription factor NF-E2-related_factor_2 -LRB- Nrf2 -RRB- were isolated from an extract of Coriandrum sativum L. -LRB- C. sativum -RRB- leaves by preparative octadecyl_silica column chromatography .
25505069	0	Nrf2	48,52	Keap1	173,178	Nrf2	Keap1	4780	9817	Gene	Gene	Activation|compound|START_ENTITY _|dobj|Activation _|nmod|END_ENTITY	Kaposi 's _ Sarcoma-Associated Herpesvirus Induces Nrf2 Activation in Latently-Infected Endothelial Cells Through SQSTM1 Phosphorylation and Interaction with Polyubiquitinated Keap1 .
25742418	0	Nrf2	34,38	Keap1	52,57	Nrf2	Keap1	4780	9817	Gene	Gene	START_ENTITY|acl|Signaling Signaling|nmod|Cross-Linking Cross-Linking|compound|END_ENTITY	Tetrachlorobenzoquinone Activates Nrf2 Signaling by Keap1 Cross-Linking and Ubiquitin Translocation but Not Keap1-Cullin3 Complex Dissociation .
25976679	0	Nrf2	80,84	Keap1	54,59	Nrf2	Keap1	4780	9817	Gene	Gene	Leads|nmod|START_ENTITY Leads|nsubj|Downregulation Downregulation|nmod|INrf2 INrf2|appos|END_ENTITY	Aromatase Inhibitor-Mediated Downregulation of INrf2 -LRB- Keap1 -RRB- Leads to Increased Nrf2 and Resistance in Breast_Cancer .
26012548	0	Nrf2	22,26	Keap1	69,74	Nrf2	Keap1	4780	9817	Gene	Gene	Activation|compound|START_ENTITY Activation|dep|Degradation Degradation|compound|END_ENTITY	TLR Signaling Induces Nrf2 Pathway Activation through p62 - Triggered Keap1 Degradation .
26057936	0	Nrf2	44,48	Keap1	20,25	Nrf2	Keap1	4780	9817	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|interactions interactions|amod|END_ENTITY	Structural basis of Keap1 interactions with Nrf2 .
26282199	0	Nrf2	22,26	Keap1	49,54	Nrf2	Keap1	4780	9817	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|degradation degradation|amod|END_ENTITY	Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation .
26282199	0	Nrf2	22,26	Keap1	49,54	Nrf2	Keap1	4780	9817	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|degradation degradation|amod|END_ENTITY	Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation .
26348991	0	Nrf2	84,88	Keap1	51,56	Nrf2	Keap1	4780	9817	Gene	Gene	Affinity|nmod|START_ENTITY END_ENTITY|nmod|Affinity	Structural and Dynamic Characterization of Mutated Keap1 for Varied Affinity toward Nrf2 : A Molecular Dynamics Simulation Study .
26381178	0	Nrf2	73,77	Keap1	131,136	Nrf2	Keap1	4780	9817	Gene	Gene	activates|dobj|START_ENTITY activates|advcl|promoting promoting|dobj|degradation degradation|nmod|END_ENTITY	PF-4708671 , a specific inhibitor of p70 ribosomal S6_kinase_1 , activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1 .
26453926	0	Nrf2	21,25	Keap1	47,52	Nrf2	Keap1	4780	9817	Gene	Gene	pathway|amod|START_ENTITY activates|dobj|pathway activates|advcl|targeting targeting|dobj|expression expression|amod|END_ENTITY	MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression .
26653613	0	Nrf2	41,45	Keap1	46,51	Nrf2	Keap1	4780	9817	Gene	Gene	inhibitors|nmod|START_ENTITY profiling|nmod|inhibitors profiling|dep|interactions interactions|amod|END_ENTITY	Thermodynamic profiling of inhibitors of Nrf2 : Keap1 interactions .
10747902	1	Nrf2	78,82	MafK	101,105	Nrf2	MafK	4780	7975	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation by Nrf2 and repression by MafK .
21638050	0	Nrf2	17,21	MiR-28	0,6	Nrf2	MiR-28	4780	407020	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism .
18757529	0	Nrf2	0,4	Mrp	52,55	Nrf2	Mrp	18024(Tax:10090)	17250(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Nrf2 - and PPAR_alpha-mediated regulation of hepatic Mrp transporters after exposure to perfluorooctanoic_acid and perfluorodecanoic_acid .
16426233	0	Nrf2	8,12	Mrp2	38,42	Nrf2	Mrp2	18024(Tax:10090)	12780(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|amod|END_ENTITY	Role of Nrf2 in the regulation of the Mrp2 -LRB- ABCC2 -RRB- gene .
23043106	0	Nrf2	125,129	NF-E2-related_factor_2	101,123	Nrf2	NF-E2-related factor 2	18024(Tax:10090)	18024(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related_factor_2 -LRB- Nrf2 -RRB- activation .
26773873	0	Nrf2	140,144	NF-E2-related_factor_2	116,138	Nrf2	NF-E2-related factor 2	4780	4780	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	The novel triterpenoid_RTA_408 protects human retinal_pigment_epithelial cells against H2O2-induced cell injury via NF-E2-related_factor_2 -LRB- Nrf2 -RRB- activation .
23496811	0	Nrf2	67,71	NF-kB	94,99	Nrf2	NF-kB	83619(Tax:10116)	309165(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY downregulates|dobj|expression downregulates|nmod|activation activation|nmod|END_ENTITY	Indoxyl_sulfate , a uremic toxin , downregulates renal expression of Nrf2 through activation of NF-kB .
17462537	0	Nrf2	10,14	NQO1	41,45	Nrf2	NQO1	4780	1728	Gene	Gene	Action|nmod|START_ENTITY Action|nmod|expression expression|compound|END_ENTITY	Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin .
18813798	0	Nrf2	80,84	NQO1	71,75	Nrf2	NQO1	4780	1728	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic_acid in human leukemia HL-60 cells .
19452436	0	Nrf2	160,164	NQO1	48,52	Nrf2	NQO1	18024(Tax:10090)	18104(Tax:10090)	Gene	Gene	accumulation|nmod|START_ENTITY chinensis|nmod|accumulation chinensis|nsubj|Induction Induction|nmod|END_ENTITY	Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2 .
22010800	0	Nrf2	12,16	NQO1	43,47	Nrf2	NQO1	4780	1728	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Dynamics of Nrf2 and Keap1 in ARE-mediated NQO1 expression by wasabi 6 - -LRB- methylsulfinyl -RRB- hexyl_isothiocyanate .
21443946	0	Nrf2	0,4	Nox4	142,146	Nrf2	Nox4	4780	50507	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|promoter promoter|amod|END_ENTITY	Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium : identification of functional antioxidant response elements on the Nox4 promoter .
21443946	0	Nrf2	0,4	Nox4	33,37	Nrf2	Nox4	4780	50507	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium : identification of functional antioxidant response elements on the Nox4 promoter .
21554947	0	Nrf2	15,19	Nox4	0,4	Nrf2	Nox4	18024(Tax:10090)	50490(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo .
21821009	0	Nrf2	46,50	Nqo1	25,29	Nrf2	Nqo1	4780	1728	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe .
26079183	0	Nrf2	100,104	Nuclear_Factor_Erythroid_2-Related_Factor_2	55,98	Nrf2	Nuclear Factor Erythroid 2-Related Factor 2	83619(Tax:10116)	83619(Tax:10116)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of Piperlongumine Analogues and Discovery of Nuclear_Factor_Erythroid_2-Related_Factor_2 -LRB- Nrf2 -RRB- Activators as Potential Neuroprotective Agents .
22459801	0	Nrf2	35,39	Nuclear_factor_erythroid_2-like_2	0,33	Nrf2	Nuclear factor erythroid 2-like 2	4780	4780	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nuclear_factor_erythroid_2-like_2 -LRB- Nrf2 -RRB- expression in end-stage liver_disease .
26700459	0	Nrf2	15,19	ORP150	67,73	Nrf2	ORP150	4780	10525	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid_cancer cells .
25280775	0	Nrf2	78,82	Oatp1b2	113,120	Nrf2	Oatp1b2	18024(Tax:10090)	28253(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Protection against phalloidin-induced liver_injury by oleanolic_acid involves Nrf2 activation and suppression of Oatp1b2 .
24380877	0	Nrf2	0,4	PEPT1	57,62	Nrf2	PEPT1	4780	6564	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon_carcinoma cell line Caco-2 .
25727958	0	Nrf2	77,81	PI3K	148,152	Nrf2	PI3K	4780	5294	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways .
25430543	0	Nrf2	85,89	PPARy	20,25	Nrf2	PPARy	4780	5468	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Pleiotropic Role of PPARy in Intracerebral_Hemorrhage : An Intricate System Involving Nrf2 , RXR , and NF-kB .
26923328	0	Nrf2	38,42	RNA-binding_motif_protein_47	0,28	Nrf2	RNA-binding motif protein 47	18024(Tax:10090)	245945(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	RNA-binding_motif_protein_47 inhibits Nrf2 activity to suppress tumor growth in lung_adenocarcinoma .
20930048	0	Nrf2	21,25	SHP	36,39	Nrf2	SHP	18024(Tax:10090)	23957(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism .
21670314	0	Nrf2	41,45	TNF	0,3	Nrf2	TNF	4780	7124	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TNF mediates the sustained activation of Nrf2 in human monocytes .
26721202	0	Nrf2	18,22	TRAIL	45,50	Nrf2	TRAIL	4780	8743	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Downregulation of Nrf2 by the combination of TRAIL and Valproic_acid induces apoptotic cell death of TRAIL-resistant papillary_thyroid_cancer cells via suppression of Bcl-xL .
23727018	0	Nrf2	27,31	USP15	0,5	Nrf2	USP15	4780	9958	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	USP15 negatively regulates Nrf2 through deubiquitination of Keap1 .
22033923	0	Nrf2	109,113	VEGF	54,58	Nrf2	VEGF	4780	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Interplay between vascular_endothelial_growth_factor -LRB- VEGF -RRB- and nuclear_factor_erythroid_2-related_factor-2 -LRB- Nrf2 -RRB- : implications for preeclampsia .
25169428	0	Nrf2	128,132	c-Jun	91,96	Nrf2	c-Jun	4780	3725	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression .
20806931	0	Nrf2	71,75	carbonyl_reductase_3	20,40	Nrf2	carbonyl reductase 3	4780	874	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of human carbonyl_reductase_3 -LRB- CBR3 ; SDR21C2 -RRB- expression by Nrf2 in cultured cancer cells .
12435735	0	Nrf2	0,4	ferritin_H	31,41	Nrf2	ferritin H	18024(Tax:10090)	67634(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Nrf2 mediates the induction of ferritin_H in response to xenobiotics and cancer chemopreventive dithiolethiones .
25270507	0	Nrf2	0,4	fibroblast_growth_factor_21	13,40	Nrf2	fibroblast growth factor 21	18024(Tax:10090)	56636(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Nrf2 induces fibroblast_growth_factor_21 in diabetic mice .
10559251	0	Nrf2	100,104	gamma-glutamylcysteine_synthetase	14,47	Nrf2	gamma-glutamylcysteine synthetase	4780	2729	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of gamma-glutamylcysteine_synthetase subunit gene expression by the transcription factor Nrf2 .
10751553	0	Nrf2	0,4	gamma-glutamylcysteine_synthetase	101,134	Nrf2	gamma-glutamylcysteine synthetase	4780	2729	Gene	Gene	regulation|amod|START_ENTITY regulation|dep|expression expression|nmod|gene gene|amod|END_ENTITY	Nrf2 and c-Jun regulation of antioxidant response element -LRB- ARE -RRB- - mediated expression and induction of gamma-glutamylcysteine_synthetase heavy subunit gene .
24571482	0	Nrf2	46,50	hMOF	30,34	Nrf2	hMOF	4780	84148	Gene	Gene	acetylates|dobj|START_ENTITY acetylates|nsubj|END_ENTITY	The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung_cancer .
10473555	0	Nrf2	0,4	heme_oxygenase-1	70,86	Nrf2	heme oxygenase-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|induction induction|nmod|gene gene|amod|END_ENTITY	Nrf2 , a Cap'n ` Collar transcription factor , regulates induction of the heme_oxygenase-1 gene .
12453873	0	Nrf2	82,86	heme_oxygenase-1	19,35	Nrf2	heme oxygenase-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|gene gene|amod|END_ENTITY	Heme activates the heme_oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2 .
12699247	0	Nrf2	128,132	heme_oxygenase-1	60,76	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	involvement|nmod|START_ENTITY Interaction|dep|involvement Interaction|nmod|induction induction|amod|END_ENTITY	Interaction of heme with nitroxyl or nitric_oxide amplifies heme_oxygenase-1 induction : involvement of the transcription factor Nrf2 .
15870071	0	Nrf2	101,105	heme_oxygenase-1	35,51	Nrf2	heme oxygenase-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY erythroid|dobj|factor factor|acl|erythroid END_ENTITY|nmod|factor	Fibroblast_growth_factor-1 induces heme_oxygenase-1 via nuclear factor erythroid 2-related factor 2 -LRB- Nrf2 -RRB- in spinal cord astrocytes : consequences for motor neuron survival .
16482620	0	Nrf2	97,101	heme_oxygenase-1	54,70	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	translocation|amod|START_ENTITY stimulating|dobj|translocation up-regulates|advcl|stimulating up-regulates|dobj|expression expression|amod|END_ENTITY	1,2,3,4,6-penta-O-galloyl-beta-D-glucose up-regulates heme_oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular_signal-regulated_kinase-dependent manner in HepG2 cells .
17535857	0	Nrf2	76,80	heme_oxygenase-1	14,30	Nrf2	heme oxygenase-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	demethoxy_curcuminoids|nmod|START_ENTITY Regulation|nmod|demethoxy_curcuminoids Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 expression by demethoxy_curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells .
20064636	0	Nrf2	121,125	heme_oxygenase-1	13,29	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	requires|dobj|START_ENTITY lymphocytes|parataxis|requires lymphocytes|nsubj|Induction Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta -LRB- 12,14 -RRB- - prostaglandin_J -LRB- 2 -RRB- requires Nrf2 .
20074672	0	Nrf2	59,63	heme_oxygenase-1	27,43	Nrf2	heme oxygenase-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Taurine_chloramine induces heme_oxygenase-1 expression via Nrf2 activation in murine macrophages .
20486211	0	Nrf2	106,110	heme_oxygenase-1	125,141	Nrf2	heme oxygenase-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	START_ENTITY|acl|activation activation|nmod|induction induction|amod|END_ENTITY	Inhibition of neointimal formation by trans-resveratrol : role of phosphatidyl_inositol 3-kinase-dependent Nrf2 activation in heme_oxygenase-1 induction .
20558128	0	Nrf2	115,119	heme_oxygenase-1	20,36	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Piceatannol induces heme_oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling .
20920477	0	Nrf2	99,103	heme_oxygenase-1	49,65	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	activation|nmod|START_ENTITY increases|nmod|activation increases|dobj|expression expression|amod|END_ENTITY	Low concentration of 4-hydroxy_hexenal increases heme_oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells .
22095074	0	Nrf2	72,76	heme_oxygenase-1	22,38	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Guggulsterone induces heme_oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells : PTEN as a putative target .
23036869	0	Nrf2	93,97	heme_oxygenase-1	44,60	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	activation|amod|START_ENTITY inhibition|nmod|activation reductase|nmod|inhibition reductase|dobj|induction induction|amod|END_ENTITY	Methionine_sulfoxide reductase A attenuates heme_oxygenase-1 induction through inhibition of Nrf2 activation .
23318726	0	Nrf2	94,98	heme_oxygenase-1	117,133	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	expressions|amod|START_ENTITY expressions|amod|END_ENTITY	Butein protects human_dental_pulp cells from hydrogen_peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme_oxygenase-1 expressions .
23567851	0	Nrf2	74,78	heme_oxygenase-1	21,37	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Homocysteine induces heme_oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cell .
24063008	0	Nrf2	100,104	heme_oxygenase-1	59,75	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Cordyceps sinensis increases hypoxia tolerance by inducing heme_oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells .
25871879	0	Nrf2	121,125	heme_oxygenase-1	89,105	Nrf2	heme oxygenase-1	18024(Tax:10090)	15368(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY independent|nmod|activation independent|amod|END_ENTITY	Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme_oxygenase-1 independent of Nrf2 activation .
26291278	0	Nrf2	26,30	heme_oxygenase-1	121,137	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	regulation|nmod|START_ENTITY serine|nsubj|regulation serine|dobj|phosphorylation phosphorylation|nmod|transcription transcription|nmod|gene gene|amod|END_ENTITY	Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme_oxygenase-1 gene .
26404762	0	Nrf2	116,120	heme_oxygenase-1	65,81	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	pathways|compound|START_ENTITY inhibiting|dobj|pathways down-regulated|advcl|inhibiting down-regulated|dobj|expression expression|amod|END_ENTITY	2,3,5,6-Tetramethylpyrazine -LRB- TMP -RRB- down-regulated arsenic-induced heme_oxygenase-1 and ARS2 expression by inhibiting Nrf2 , NF-kB , AP-1 and MAPK pathways in human proximal tubular cells .
26445536	0	Nrf2	62,66	heme_oxygenase-1	26,42	Nrf2	heme oxygenase-1	4780	3162	Gene	Gene	activation|amod|START_ENTITY induce|nmod|activation induce|dobj|expression expression|amod|END_ENTITY	Gold nanoparticles induce heme_oxygenase-1 expression through Nrf2 activation and Bach1 export in human vascular endothelial cells .
16574070	0	Nrf2	56,60	heme_oxygenase_1	25,41	Nrf2	heme oxygenase 1	4780	3162	Gene	Gene	activation|amod|START_ENTITY induction|nmod|activation induction|amod|END_ENTITY	Carbon_monoxide mediates heme_oxygenase_1 induction via Nrf2 activation in hepatoma cells .
24755082	0	Nrf2	49,53	hemeoxygenase-1	14,29	Nrf2	hemeoxygenase-1	83619(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of hemeoxygenase-1 gene expression by Nrf2 and c-Jun in tertiary_butylhydroquinone-stimulated rat primary astrocytes .
21127061	0	Nrf2	0,4	interleukin-6	13,26	Nrf2	interleukin-6	18024(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Nrf2 induces interleukin-6 -LRB- IL-6 -RRB- expression via an antioxidant response element within the IL-6 promoter .
19720220	0	Nrf2	67,71	interleukin-8	22,35	Nrf2	interleukin-8	4780	3576	Gene	Gene	pathways|amod|START_ENTITY system|nmod|pathways system|amod|END_ENTITY	Heat stress activates interleukin-8 and the antioxidant system via Nrf2 pathways in human_dental_pulp cells .
16293230	0	Nrf2	57,61	keap1	36,41	Nrf2	keap1	18024(Tax:10090)	50868(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|deletion deletion|nmod|gene gene|amod|END_ENTITY	Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute_drug_toxicity .
24029383	0	Nrf2	0,4	lipocalin-prostaglandin_D_synthase	40,74	Nrf2	lipocalin-prostaglandin D synthase	18024(Tax:10090)	19215(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|expression expression|nmod|END_ENTITY	Nrf2 is essential for the expression of lipocalin-prostaglandin_D_synthase induced by prostaglandin_D2 .
21926171	0	Nrf2	19,23	miR-200a	0,8	Nrf2	miR-200a	4780	406983	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast_cancer cells .
26282218	0	Nrf2	134,138	miR-34a	123,130	Nrf2	miR-34a	4780	407040	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Schisandrin_B shows neuroprotective effect in 6-OHDA-induced Parkinson 's _ disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway .
26282218	0	Nrf2	134,138	miR-34a	123,130	Nrf2	miR-34a	4780	407040	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Schisandrin_B shows neuroprotective effect in 6-OHDA-induced Parkinson 's _ disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway .
19799917	0	Nrf2	66,70	nuclear_factor-erythroid_2-related_factor-2	21,64	Nrf2	nuclear factor-erythroid 2-related factor-2	4780	4780	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A protective role of nuclear_factor-erythroid_2-related_factor-2 -LRB- Nrf2 -RRB- in inflammatory disorders .
18588981	0	Nrf2	0,4	nuclear_factor-kappaB	75,96	Nrf2	nuclear factor-kappaB	4780	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear_factor-kappaB .
24854091	0	Nrf2	44,48	nuclear_factor_E2-related_factor_2	8,42	Nrf2	nuclear factor E2-related factor 2	4780	4780	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of nuclear_factor_E2-related_factor_2 -LRB- Nrf2 -RRB- in epidermal differentiation .
26105441	1	Nrf2	68,72	nuclear_factor_erythroid_2-related_factor_2	23,66	Nrf2	nuclear factor erythroid 2-related factor 2	4780	4780	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the nuclear_factor_erythroid_2-related_factor_2 -LRB- Nrf2 -RRB- in preeclampsia .
26012548	0	Nrf2	22,26	p62	54,57	Nrf2	p62	4780	23636	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	TLR Signaling Induces Nrf2 Pathway Activation through p62 - Triggered Keap1 Degradation .
17234762	0	Nrf2	31,35	prx1	6,10	Nrf2	prx1	4780	5052	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation : implication to tumor biology .
16219762	0	Nrf2	149,153	thioredoxin_reductase_1	107,130	Nrf2	thioredoxin reductase 1	83619(Tax:10116)	58819(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin_reductase_1 via activation of Nrf2 .
25002527	0	Nrf2	0,4	xCT	41,44	Nrf2	xCT	4780	23657	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Nrf2 - and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder_carcinoma cells to proteasome inhibition .
26044038	0	Nrf2	26,30	xCT	67,70	Nrf2	xCT	4780	23657	Gene	Gene	Upregulation|amod|START_ENTITY Upregulation|nmod|END_ENTITY	Correction for Ye et al. , Nrf2 - and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder_Carcinoma Cells to Proteasome Inhibition .
21949864	0	Nrg1	9,13	TRPV1	49,54	Nrg1	TRPV1	211323(Tax:10090)	193034(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Type III Nrg1 back signaling enhances functional TRPV1 along sensory axons contributing to basal and inflammatory thermal pain sensation .
8552602	0	Nrl	52,55	rhodopsin	80,89	Nrl	rhodopsin	4901	6010	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression .
8939891	0	Nrl	30,33	rhodopsin	45,54	Nrl	rhodopsin	521544(Tax:9913)	509933(Tax:9913)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures .
19682578	0	Nrp/b	18,23	nuclear_restrict_protein_in_brain	25,58	Nrp/b	nuclear restrict protein in brain	13803(Tax:10090)	13803(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Nrp/b -LRB- nuclear_restrict_protein_in_brain -RRB- suppresses the malignant phenotype in the C6/ST1 glioma cell line .
23577203	0	Nrp1	13,17	CD4	0,3	Nrp1	CD4	18186(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- Nrp1 -LRB- + -RRB- T cells synergize with rapamycin to prevent murine cardiac allorejection in immunocompetent recipients .
22761789	0	Nrp2a	21,26	Dre-miR-2188	0,12	Nrp2a	Dre-miR-2188	405901(Tax:7955)	100628882	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos .
15331764	0	Nse1	0,4	Nse2	6,10	Nse1	Nse2	197370	286053	Gene	Gene	play|advmod|START_ENTITY play|nsubj|END_ENTITY	Nse1 , Nse2 , and a novel subunit of the Smc5-Smc6 complex , Nse3 , play a crucial role in meiosis .
15331764	0	Nse2	6,10	Nse1	0,4	Nse2	Nse1	286053	197370	Gene	Gene	play|nsubj|START_ENTITY play|advmod|END_ENTITY	Nse1 , Nse2 , and a novel subunit of the Smc5-Smc6 complex , Nse3 , play a crucial role in meiosis .
25085976	0	Ntf3	0,4	Sip1	24,28	Ntf3	Sip1	102467582	24136(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling .
12042306	0	Ntg2p	0,5	Mlh1p	188,193	Ntg2p	Mlh1p	854114(Tax:4932)	855203(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ntg2p , a Saccharomyces_cerevisiae DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidative DNA damage , interacts with the DNA mismatch repair protein Mlh1p .
11687289	0	Ntsr2	35,40	neurotensin_receptor_2	6,28	Ntsr2	neurotensin receptor 2	18217(Tax:10090)	18217(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mouse neurotensin_receptor_2 gene -LRB- Ntsr2 -RRB- : genomic organization , transcriptional regulation and genetic mapping on chromosome 12 .
23921553	0	NuMA	0,4	CDK1	24,28	NuMA	CDK1	4926	983	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function .
10913114	0	NuMA	65,69	GAS41	0,5	NuMA	GAS41	4926	8089	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	GAS41 , a highly conserved protein in eukaryotic nuclei , binds to NuMA .
11781568	0	NuMA	41,45	Partner_of_inscuteable	12,34	NuMA	Partner of inscuteable	4926	29899	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	A mammalian Partner_of_inscuteable binds NuMA and regulates mitotic spindle organization .
16638812	0	Nubp1	36,41	KIFC5A	14,20	Nubp1	KIFC5A	26425(Tax:10090)	16580(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Motor protein KIFC5A interacts with Nubp1 and Nubp2 , and is implicated in the regulation of centrosome duplication .
24829503	0	NucB2	21,26	nesfatin-1	10,20	NucB2	nesfatin-1	59295(Tax:10116)	59295(Tax:10116)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role of nesfatin-1 / NucB2 in dehydration-induced anorexia .
11687588	0	Nuclear_DNA_helicase_II	0,23	RNA_helicase_A	24,38	Nuclear DNA helicase II	RNA helicase A	1660	1660	Gene	Gene	START_ENTITY|parataxis|binds binds|nsubj|END_ENTITY	Nuclear_DNA_helicase_II / RNA_helicase_A binds to filamentous actin .
25977470	0	Nuclear_Factor-Erythroid_2-Related_Factor_2	28,71	NRF2	73,77	Nuclear Factor-Erythroid 2-Related Factor 2	NRF2	4780	4780	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Hydrogen_Sulfide Levels and Nuclear_Factor-Erythroid_2-Related_Factor_2 -LRB- NRF2 -RRB- Activity Are Attenuated in the Setting of Critical_Limb_Ischemia -LRB- CLI -RRB- .
18617174	0	Nuclear_Factor-kappa_B	4,26	p50	27,30	Nuclear Factor-kappa B	p50	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	The Nuclear_Factor-kappa_B p50 subunit is involved in flow-induced outward arterial remodeling .
25895590	0	Nuclear_Factor_Erythroid_2-Related_Factor_2	8,51	DJ-1	132,136	Nuclear Factor Erythroid 2-Related Factor 2	DJ-1	18024(Tax:10090)	57320(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Nuclear_Factor_Erythroid_2-Related_Factor_2 in the Oxidative Stress-Dependent Hypertension Associated With the Depletion of DJ-1 .
26079183	0	Nuclear_Factor_Erythroid_2-Related_Factor_2	55,98	Nrf2	100,104	Nuclear Factor Erythroid 2-Related Factor 2	Nrf2	83619(Tax:10116)	83619(Tax:10116)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of Piperlongumine Analogues and Discovery of Nuclear_Factor_Erythroid_2-Related_Factor_2 -LRB- Nrf2 -RRB- Activators as Potential Neuroprotective Agents .
25171655	0	Nuclear_Factor_Erythroid_2-Related_Factor_2	0,43	Toll-Like_Receptor_4	54,74	Nuclear Factor Erythroid 2-Related Factor 2	Toll-Like Receptor 4	18024(Tax:10090)	21898(Tax:10090)	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	Nuclear_Factor_Erythroid_2-Related_Factor_2 Regulates Toll-Like_Receptor_4 Innate Responses in Mouse Liver_Ischemia-Reperfusion Injury Through Akt-Forkhead box Protein O1 Signaling Network .
25138274	0	Nuclear_Factor_I-C	0,18	Dentin_Sialophosphoprotein	36,62	Nuclear Factor I-C	Dentin Sialophosphoprotein	4782	1834	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|xcomp|END_ENTITY	Nuclear_Factor_I-C -LRB- NFIC -RRB- Regulates Dentin_Sialophosphoprotein -LRB- DSPP -RRB- and E-cadherin via Control of Kr ppel-like Factor 4 -LRB- KLF4 -RRB- During Dentinogenesis .
9920279	0	Nuclear_factor-kappaB	0,21	Rel	22,25	Nuclear factor-kappaB	Rel	4790	5966	Gene	Gene	proteins|nummod|START_ENTITY proteins|compound|END_ENTITY	Nuclear_factor-kappaB / Rel proteins : a point of convergence of signalling pathways relevant in neuronal function and dysfunction .
11310828	0	Nuclear_factor-kappaB	0,21	cyclooxygenase-2	32,48	Nuclear factor-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nuclear_factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric_cancer cells .
15112579	0	Nuclear_factor-kappa_B	0,22	cyclooxygenase-2	33,49	Nuclear factor-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Nuclear_factor-kappa_B regulates cyclooxygenase-2 expression and cell proliferation in human colorectal_carcinoma tissue .
15541363	0	Nuclear_factor_1	0,16	GLUT4	75,80	Nuclear factor 1	GLUT4	18015(Tax:10090)	20528(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Nuclear_factor_1 regulates adipose tissue-specific expression in the mouse GLUT4 gene .
2926813	0	Nuclear_factor_I	0,16	Sp1	63,66	Nuclear factor I	Sp1	4782	6667	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	Nuclear_factor_I can functionally replace transcription factor Sp1 in a U2 small nuclear RNA gene enhancer .
25777441	0	Nuclear_factor_I-C	0,18	E-cadherin	29,39	Nuclear factor I-C	E-cadherin	4782	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nuclear_factor_I-C regulates E-cadherin via control of KLF4 in breast_cancer .
25879941	0	Nuclear_factor_I-C	0,18	E-cadherin	29,39	Nuclear factor I-C	E-cadherin	4782	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nuclear_factor_I-C regulates E-cadherin via control of KLF4 in breast_cancer .
25879941	0	Nuclear_factor_I-C	0,18	E-cadherin	29,39	Nuclear factor I-C	E-cadherin	4782	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nuclear_factor_I-C regulates E-cadherin via control of KLF4 in breast_cancer .
26403732	0	Nuclear_factor_I-C	1,19	TGF-b	116,121	Nuclear factor I-C	TGF-b	4782	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Nuclear_factor_I-C inhibits platelet-derived growth factor-induced enhancement of dermal fibroblast sensitivity to TGF-b -RSB- .
7641693	0	Nuclear_factor_RIP140	0,21	estrogen_receptor	66,83	Nuclear factor RIP140	estrogen receptor	8204	2099	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Nuclear_factor_RIP140 modulates transcriptional activation by the estrogen_receptor .
22459801	0	Nuclear_factor_erythroid_2-like_2	0,33	Nrf2	35,39	Nuclear factor erythroid 2-like 2	Nrf2	4780	4780	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nuclear_factor_erythroid_2-like_2 -LRB- Nrf2 -RRB- expression in end-stage liver_disease .
24621507	0	Nuclear_interactor_of_ARF_and_Mdm2	0,34	p53	75,78	Nuclear interactor of ARF and Mdm2	p53	84897;4193	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Nuclear_interactor_of_ARF_and_Mdm2 regulates multiple pathways to activate p53 .
19946894	0	Nuclear_protein_1	0,17	ATF4	133,137	Nuclear protein 1	ATF4	26471	468	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|regulator regulator|nmod|activation activation|nmod|END_ENTITY	Nuclear_protein_1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4 .
19946894	0	Nuclear_protein_1	0,17	ATF4	29,33	Nuclear protein 1	ATF4	26471	468	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Nuclear_protein_1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4 .
19721712	0	Nuclear_receptor_SHP	0,20	miR-206	31,38	Nuclear receptor SHP	miR-206	8431	406989	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Nuclear_receptor_SHP activates miR-206 expression via a cascade dual inhibitory mechanism .
27048878	0	Nuclear_receptor_TLX	0,20	TGF-b	30,35	Nuclear receptor TLX	NR2E1	7101	7101	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nuclear_receptor_TLX inhibits TGF-b signaling in glioblastoma .
26109058	0	Nuclear_respiratory_factor_2	0,28	SIRT3	37,42	Nuclear respiratory factor 2	SIRT3	2553	23410	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Nuclear_respiratory_factor_2 induces SIRT3 expression .
16751805	0	Nucleolin	0,9	Hdm2	19,23	Nucleolin	Hdm2	4691	4193	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization .
26103640	0	Nucleolin	101,110	IGFBP-5	0,7	Nucleolin	IGFBP-5	4691	3488	Gene	Gene	Independently|nmod|START_ENTITY Independently|compound|END_ENTITY	IGFBP-5 Promotes Fibrosis Independently of Its Translocation to the Nucleus and Its Interaction with Nucleolin and IGF .
19393617	0	Nucleolin	58,67	PinX1	0,5	Nucleolin	PinX1	4691	54984	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression .
20336191	0	Nucleolin	0,9	Proliferating_Cell_Nuclear_Antigen	23,57	Nucleolin	Proliferating Cell Nuclear Antigen	4691	5111	Gene	Gene	Binds|nsubj|START_ENTITY Binds|nmod|END_ENTITY	Nucleolin Binds to the Proliferating_Cell_Nuclear_Antigen and Inhibits Nucleotide Excision Repair .
18025046	0	Nucleolin	0,9	cPLA2alpha	70,80	Nucleolin	cPLA2alpha	4691	5321	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2alpha in phorbol_ester-treated non-small_cell_lung_cancer A549 cells .
23594402	0	Nucleolin	0,9	heat_shock_protein_32	80,101	Nucleolin	heat shock protein 32	25135(Tax:10116)	24451(Tax:10116)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Nucleolin protects the heart from ischaemia-reperfusion injury by up-regulating heat_shock_protein_32 .
26091065	0	Nucleophosmin	33,46	CRM1	68,72	Nucleophosmin	CRM1	4869	7514	Gene	Gene	Recognition|compound|START_ENTITY Recognition|nmod|END_ENTITY	Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1 : Molecular Basis of Aberrant Transport .
18371977	0	Nucleophosmin	0,13	HEXIM1	29,35	Nucleophosmin	HEXIM1	4869	10614	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription .
20585519	0	Nucleophosmin	0,13	K-Ras	37,42	Nucleophosmin	K-Ras	4869	3845	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Nucleophosmin and nucleolin regulate K-Ras signaling .
19103589	0	Nucleophosmin	0,13	granzyme_M	75,85	Nucleophosmin	granzyme M	4869	3004	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme_M during natural killer cell-mediated killing .
12080348	0	Nucleophosmin	0,13	p53	70,73	Nucleophosmin	p53	4869	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Nucleophosmin regulates the stability and transcriptional activity of p53 .
26405153	0	Nucleophosmin-1	107,122	NPM1	124,128	Nucleophosmin-1	NPM1	4869	4869	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Allogeneic hematopoietic cell transplantation in acute_myeloid_leukemia with normal karyotype and isolated Nucleophosmin-1 -LRB- NPM1 -RRB- mutation : outcome strongly correlates with disease status .
20400501	0	Nucleoredoxin	0,13	Toll-like_receptor_4	35,55	Nucleoredoxin	Toll-like receptor 4	18230(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nucleoredoxin negatively regulates Toll-like_receptor_4 signaling via recruitment of flightless-I to myeloid_differentiation_primary_response_gene _ -LRB- 88 -RRB- .
20970343	0	Nucleoredoxin	0,13	dishevelled	79,90	Nucleoredoxin	dishevelled	18230(Tax:10090)	13542(Tax:10090)	Gene	Gene	sustains|nsubj|START_ENTITY sustains|dobj|Wnt/b-catenin Wnt/b-catenin|acl|signaling signaling|advcl|retaining retaining|dobj|pool pool|nmod|protein protein|amod|END_ENTITY	Nucleoredoxin sustains Wnt/b-catenin signaling by retaining a pool of inactive dishevelled protein .
17567240	0	Nucleoredoxin	0,13	thioredoxin	23,34	Nucleoredoxin	thioredoxin	64359	7295	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	Nucleoredoxin , a novel thioredoxin family member involved in cell growth and differentiation .
1851361	0	Nucleoside_diphosphatase	0,24	NDPase	26,32	Nucleoside diphosphatase	NDPase	957	957	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Nucleoside_diphosphatase -LRB- NDPase -RRB- activity associated with human beta-protein amyloid fibers .
7977749	0	Nucleoside_diphosphate_kinase	0,29	CCK	81,84	Nucleoside diphosphate kinase	CCK	298410(Tax:10116)	25298(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptor receptor|compound|END_ENTITY	Nucleoside_diphosphate_kinase associated with rat pancreatic membranes regulates CCK receptor affinity .
15280446	0	Nucleoside_diphosphate_kinase_A	0,31	nm23-H1	32,39	Nucleoside diphosphate kinase A	nm23-H1	4830	4830	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Nucleoside_diphosphate_kinase_A / nm23-H1 promotes metastasis of NB69-derived human neuroblastoma .
18753248	0	Nucleosome-releasing_factor	0,27	factor_VII-activating_protease	44,74	Nucleosome-releasing factor	factor VII-activating protease	55922	3026	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Nucleosome-releasing_factor : a new role for factor_VII-activating_protease -LRB- FSAP -RRB- .
20580721	0	Nucleotide-binding_oligomerization_domain-2	0,43	toll-like_receptor-4	53,73	Nucleotide-binding oligomerization domain-2	toll-like receptor-4	257632(Tax:10090)	21898(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Nucleotide-binding_oligomerization_domain-2 inhibits toll-like_receptor-4 signaling in the intestinal epithelium .
26332444	0	Nucleotide-binding_oligomerization_domain_2	0,43	NOD2	45,49	Nucleotide-binding oligomerization domain 2	NOD2	64127	64127	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Nucleotide-binding_oligomerization_domain_2 -LRB- NOD2 -RRB- activation induces apoptosis of human oral_squamous_cell_carcinoma cells .
20702393	0	Nucling	38,45	NF-kappaB	0,9	Nucling	NF-kappaB	72565(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappaB regulates the expression of Nucling , a novel apoptosis regulator , with involvement of proteasome and caspase for its degradation .
16888627	0	Nud1p	0,5	Centriolin	28,38	Nud1p	Centriolin	854555(Tax:4932)	11064	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Nud1p , the yeast homolog of Centriolin , regulates spindle pole body inheritance in meiosis .
11734602	0	NudC	0,4	Lis1	21,25	NudC	Lis1	10726	5048	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	NudC associates with Lis1 and the dynein motor at the leading pole of neurons .
16860740	0	NudC	0,4	Plk1	21,25	NudC	Plk1	10726	5347	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	NudC is required for Plk1 targeting to the kinetochore and chromosome congression .
26704451	0	NudC	0,4	cofilin_1	62,71	NudC	cofilin 1	393893(Tax:7955)	321496(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin_1 .
18331715	0	Nudel	0,5	Cdc42GAP	12,20	Nudel	Cdc42GAP	81565	392	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells .
14970193	0	Nudel	0,5	Lis1	68,72	Nudel	Lis1	81565	5048	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein .
26878367	0	Nudix_hydrolase_19	153,171	AtNUDX19	173,181	Nudix hydrolase 19	AtNUDX19	832129(Tax:3702)	832129(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Activation of NADPH-recycling systems in leaves and roots of Arabidopsis_thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix_hydrolase_19 -LRB- AtNUDX19 -RRB- gene .
11266443	0	Num1p	9,14	Pac11p	60,66	Num1p	Pac11p	851727(Tax:4932)	852099(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast .
17022975	0	Numb	19,23	AP-2	87,91	Numb	AP-2	8650	7020	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2 .
20818436	0	Numb	0,4	Itch	29,33	Numb	Itch	8650	83737	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal .
21084860	0	Numb	67,71	Musashi_2	57,66	Numb	Musashi 2	8650	124540	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Aggressive myeloid_leukemia formation is directed by the Musashi_2 / Numb pathway .
21356309	0	Numb	0,4	Notch1	15,21	Numb	Notch1	18222(Tax:10090)	18128(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Numb regulates Notch1 , but not Notch3 , during myogenesis .
27072891	0	Numb	105,109	Par3	21,25	Numb	Par3	8650	56288	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb .
23649620	0	Numb	144,148	T_cell_factor	114,127	Numb	T cell factor	8650	3172	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/b-catenin signaling to T_cell_factor elements in the Numb promoter .
23649620	0	Numb	59,63	T_cell_factor	114,127	Numb	T cell factor	8650	3172	Gene	Gene	START_ENTITY|nmod|myoblasts myoblasts|nmod|Wnt/b-catenin Wnt/b-catenin|acl|signaling signaling|xcomp|END_ENTITY	Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/b-catenin signaling to T_cell_factor elements in the Numb promoter .
22701667	0	Numbl	18,23	MiR-34a	0,7	Numbl	MiR-34a	18223(Tax:10090)	723848(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	MiR-34a represses Numbl in murine neural_progenitor_cells and antagonizes neuronal differentiation .
15716093	0	Nup100p	118,125	Upf1p	0,5	Nup100p	Upf1p	853796(Tax:4932)	855104(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Upf1p , a highly conserved protein required for nonsense-mediated_mRNA_decay , interacts with the nuclear pore proteins Nup100p and Nup116p .
10891509	0	Nup116p	42,49	Nup82p	122,128	Nup116p	Nup82p	855066(Tax:4932)	853385(Tax:4932)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p .
19229862	0	Nup214	26,32	vitamin_D_receptor	48,66	Nup214	vitamin D receptor	8021	7421	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Oncogenic nucleoporin_CAN / Nup214 interacts with vitamin_D_receptor and modulates its function .
24244865	0	Nup358	0,6	Dishevelled	22,33	Nup358	Dishevelled	5903	8215	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nup358 interacts with Dishevelled and aPKC to regulate neuronal polarity .
17448464	0	Nup49	103,108	Rmt2	31,35	Nup49	Rmt2	852703(Tax:4932)	852076(Tax:4932)	Gene	Gene	enriched|nmod|START_ENTITY enriched|nsubjpass|END_ENTITY	The arginine methyltransferase Rmt2 is enriched in the nucleus and co-purifies with the nuclear porins Nup49 , Nup57 and Nup100 .
11071914	0	Nup53p	22,28	Nic96p	57,63	Nup53p	Nic96p	855184(Tax:4932)	850552(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The yeast nucleoporin Nup53p specifically interacts with Nic96p and is directly involved in nuclear protein import .
21698267	0	Nup62	112,117	OSBP-related_protein_8	0,22	Nup62	OSBP-related protein 8	18226(Tax:10090)	237542(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	OSBP-related_protein_8 -LRB- ORP8 -RRB- regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62 .
22110128	0	Nup62	124,129	b-catenin	47,56	Nup62	b-catenin	23636	1499	Gene	Gene	transport|nmod|START_ENTITY transport|amod|END_ENTITY	Specific armadillo repeat sequences facilitate b-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62 , Nup153 , and RanBP2/Nup358 .
10891509	0	Nup82p	122,128	Nup116p	42,49	Nup82p	Nup116p	853385(Tax:4932)	855066(Tax:4932)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p .
18175937	0	Nup88	79,84	nucleophosmin	42,55	Nup88	nucleophosmin	4927	4869	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Deguelin represses both the expression of nucleophosmin and some nucleoporins : Nup88 and Nup214 in Jurkat cells .
9348540	0	Nup93	0,5	Nic96p	39,45	Nup93	Nic96p	380283(Tax:8355)	850552(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Nup93 , a vertebrate homologue of yeast Nic96p , forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly .
11274386	0	Nur77	61,66	Akt	0,3	Nur77	Akt	15370(Tax:10090)	11651(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt phosphorylates and regulates the orphan nuclear receptor Nur77 .
11438550	0	Nur77	41,46	Akt	0,3	Nur77	Akt	3164	207	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis .
15459248	0	Nur77	64,69	CR6-interacting_factor_1	0,24	Nur77	CR6-interacting factor 1	3164	90480	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CR6-interacting_factor_1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation .
18690216	0	Nur77	56,61	Cytosporone_B	0,13	Nur77	Cytosporone B	15370(Tax:10090)	12991(Tax:10090)	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	Cytosporone_B is an agonist for nuclear orphan receptor Nur77 .
15155786	0	Nur77	82,87	DAX-1	37,42	Nur77	DAX-1	15370(Tax:10090)	11614(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation .
12753745	0	Nur77	65,70	HDAC7	0,5	Nur77	HDAC7	3164	51564	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	HDAC7 , a thymus-specific class II histone deacetylase , regulates Nur77 transcription and TCR-mediated apoptosis .
26465200	0	Nur77	74,79	HSD3B2	87,93	Nur77	HSD3B2	79240(Tax:10116)	3284	Gene	Gene	START_ENTITY|nmod|Promoter Promoter|compound|END_ENTITY	A Dietary Medium-Chain Fatty_Acid , Decanoic_Acid , Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic_Abnormalities in a Rat Model of Polycystic_Ovary_Syndrome .
16264271	0	Nur77	81,86	JunD	16,20	Nur77	JunD	3164	3727	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Menin represses JunD transcriptional activity in protein_kinase_C theta-mediated Nur77 expression .
22983157	0	Nur77	28,33	LKB1	44,48	Nur77	LKB1	15370(Tax:10090)	20869(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nummod|END_ENTITY	The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK .
25064356	0	Nur77	24,29	MMP-9	95,100	Nur77	MMP-9	3164	4318	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Orphan nuclear receptor Nur77 promotes colorectal_cancer_invasion and metastasis by regulating MMP-9 and E-cadherin .
25576055	0	Nur77	66,71	STAT3	28,33	Nur77	STAT3	15370(Tax:10090)	20848(Tax:10090)	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|compound|END_ENTITY	Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity .
18248459	0	Nur77	79,84	SerpinA3	25,33	Nur77	SerpinA3	3164	12	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Alpha_1-antichymotrypsin / SerpinA3 is a novel target of orphan nuclear receptor Nur77 .
24396871	0	Nur77	80,85	ZBP89	51,56	Nur77	ZBP89	3164	7707	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|nsubj|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
24512852	0	Nur77	80,85	ZBP89	51,56	Nur77	ZBP89	3164	7707	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|nsubj|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
22761936	0	Nur77	24,29	androgen_receptor	40,57	Nur77	androgen receptor	15370(Tax:10090)	11835(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Orphan nuclear receptor Nur77 regulates androgen_receptor gene expression in mouse ovary .
20847229	0	Nur77	14,19	b-catenin	34,43	Nur77	b-catenin	3164	1499	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of Nur77 expression by b-catenin and its mitogenic effect in colon_cancer cells .
21986938	0	Nur77	82,87	b-catenin	14,23	Nur77	b-catenin	3164	1499	Gene	Gene	action|nmod|START_ENTITY signaling|nmod|action Inhibition|acl|signaling Inhibition|nmod|END_ENTITY	Inhibition of b-catenin signaling by nongenomic action of orphan nuclear receptor Nur77 .
12021184	0	Nur77	64,69	bisphenol_a	20,31	Nur77	bisphenol a	15370(Tax:10090)	13518(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Endocrine disrupter bisphenol_a induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cells .
25284689	0	Nur77	24,29	endothelin-1	63,75	Nur77	endothelin-1	3164	1906	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells .
24885573	0	Nur77	24,29	fibroblast_growth_factor_21	63,90	Nur77	fibroblast growth factor 21	3164	26291	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Orphan nuclear receptor Nur77 mediates fasting-induced hepatic fibroblast_growth_factor_21 expression .
22186412	0	Nur77	106,111	gonadotropin-releasing_hormone	46,76	Nur77	gonadotropin-releasing hormone	15370(Tax:10090)	14714(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	ERK signaling , but not c-Raf , is required for gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced regulation of Nur77 in pituitary gonadotropes .
21146499	0	Nur77	28,33	prolactin	53,62	Nur77	prolactin	3164	5617	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells .
21319187	0	Nur77	14,19	retinoic_acid_receptor_b	32,56	Nur77	retinoic acid receptor b	3164	5915	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Enrichment of Nur77 mediated by retinoic_acid_receptor_b leads to apoptosis of human hepatocellular_carcinoma cells induced by fenretinide and histone deacetylase inhibitors .
23680840	0	Nurr1	111,116	Camk4	54,59	Nurr1	Camk4	4929	814	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|nmod|END_ENTITY	Late maternal_hypothyroidism alters the expression of Camk4 in neocortical subplate neurons : a comparison with Nurr1 labeling .
19515692	0	Nurr1	49,54	Dlk1	18,22	Nurr1	Dlk1	18227(Tax:10090)	13386(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Dlk1 , Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic_dopamine neurons .
15106839	0	Nurr1	41,46	ERK	21,24	Nurr1	ERK	4929	5594	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Differential role of ERK in cAMP-induced Nurr1 expression in N2A and C6 cells .
21865882	0	Nurr1	87,92	GFRa1	74,79	Nurr1	GFRa1	54278(Tax:10116)	25454(Tax:10116)	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	Signaling of glial_cell_line-derived_neurotrophic_factor and its receptor GFRa1 induce Nurr1 and Pitx3 to promote survival of grafted midbrain-derived neural stem cells in a rat model of Parkinson_disease .
17394463	0	Nurr1	65,70	GTP_cyclohydrolase_I	14,34	Nurr1	GTP cyclohydrolase I	18227(Tax:10090)	14528(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of GTP_cyclohydrolase_I expression by orphan receptor Nurr1 in cell culture and in vivo .
22296971	0	Nurr1	0,5	IIb	20,23	Nurr1	IIb	18227(Tax:10090)	50771(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Nurr1 regulates Top IIb and functions in axon genesis of mesencephalic dopaminergic neurons .
27036119	0	Nurr1	61,66	Nemo-like_kinase	0,16	Nurr1	Nemo-like kinase	4929	51701	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Nemo-like_kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate_cancer .
16638018	0	Nurr1	45,50	Neuropilin1	0,11	Nurr1	Neuropilin1	18227(Tax:10090)	18186(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem .
24940803	0	Nurr1	58,63	Parathyroid_hormone	0,19	Nurr1	Parathyroid hormone	54278(Tax:10116)	24694(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Parathyroid_hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription .
19144721	0	Nurr1	18,23	Pitx3	0,5	Nurr1	Pitx3	4929	5309	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression .
22363463	0	Nurr1	41,46	Pitx3	21,26	Nurr1	Pitx3	18227(Tax:10090)	18742(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Direct regulation of Pitx3 expression by Nurr1 in culture and in developing mouse midbrain .
20533997	0	Nurr1	0,5	RET	16,19	Nurr1	RET	54278(Tax:10116)	24716(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain .
26490873	0	Nurr1	0,5	Ret	48,51	Nurr1	Ret	18227(Tax:10090)	19713(Tax:10090)	Gene	Gene	Ligands|nsubj|START_ENTITY Ligands|dobj|Signaling Signaling|compound|END_ENTITY	Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate a-Synuclein Disrupted Gene Expression .
23508200	0	Nurr1	55,60	TH	51,53	Nurr1	TH	54278(Tax:10116)	25085(Tax:10116)	Gene	Gene	Genes|dep|START_ENTITY Genes|compound|END_ENTITY	Spontaneous Expression of Neurotrophic Factors and TH , Nurr1 , Nestin Genes in Long-term Culture of Bone Marrow Mesenchymal Stem Cells .
20715116	0	Nurr1	68,73	VEGF	0,4	Nurr1	VEGF	4929	7422	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression : role in VEGF-induced angiogenesis .
16999955	0	Nurr1	35,40	VIP	0,3	Nurr1	VIP	4929	7432	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	VIP is a transcriptional target of Nurr1 in dopaminergic cells .
18463503	0	Nurr1	0,5	alpha-synuclein	52,67	Nurr1	alpha-synuclein	4929	6622	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Nurr1 transcriptionally regulates the expression of alpha-synuclein .
25408954	0	Nurr1	110,115	nuclear_receptor_related_1	74,100	Nurr1	nuclear receptor related 1	4929	4929	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Effect of spontaneous term labour on the expression of the NR4A receptors nuclear_receptor_related_1 protein -LRB- Nurr1 -RRB- , neuron-derived clone 77 -LRB- Nur77 -RRB- and neuron-derived_orphan_receptor_1 -LRB- NOR1 -RRB- in human fetal membranes and myometrium .
19671681	0	Nurr1	31,36	p53	52,55	Nurr1	p53	4929	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity .
14671317	0	Nurr1	26,31	p57	0,3	Nurr1	p57	18227(Tax:10090)	12721(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	p57 -LRB- Kip2 -RRB- cooperates with Nurr1 in developing dopamine cells .
15367582	0	Nvj1p	0,5	Osh1p	83,88	Nvj1p	Osh1p	856602(Tax:4932)	851286(Tax:4932)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding_protein homolog Osh1p in Saccharomyces_cerevisiae .
1832990	0	O-6_methylguanine_DNA_methyltransferase	12,51	MGMT	53,57	O-6 methylguanine DNA methyltransferase	MGMT	4255	4255	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of O-6_methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- in drug resistance and strategies for its inhibition .
25068034	0	O-GlcNAc	34,42	O-GlcNAcase	52,63	O-GlcNAc	O-GlcNAcase	8473	10724	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of diazirine-modified O-GlcNAc by human O-GlcNAcase .
18174169	0	O-GlcNAc	31,39	O-linked_N-acetylglucosaminyltransferase	90,130	O-GlcNAc	O-linked N-acetylglucosaminyltransferase	8473	8473	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked_N-acetylglucosaminyltransferase .
18288188	0	O-GlcNAc_transferase	34,54	insulin	58,65	O-GlcNAc transferase	insulin	8473	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Phosphoinositide signalling links O-GlcNAc_transferase to insulin resistance .
25068034	0	O-GlcNAcase	52,63	O-GlcNAc	34,42	O-GlcNAcase	O-GlcNAc	10724	8473	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of diazirine-modified O-GlcNAc by human O-GlcNAcase .
20198314	0	O-GlcNAcase	61,72	beta-N-acetylglucosaminidase	31,59	O-GlcNAcase	beta-N-acetylglucosaminidase	10724	10724	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Elevation of nucleocytoplasmic beta-N-acetylglucosaminidase -LRB- O-GlcNAcase -RRB- activity in thyroid_cancers .
18174169	0	O-linked_N-acetylglucosaminyltransferase	90,130	O-GlcNAc	31,39	O-linked N-acetylglucosaminyltransferase	O-GlcNAc	8473	8473	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked_N-acetylglucosaminyltransferase .
16714295	0	O-linked_beta-N-acetylglucosamine_transferase	25,70	Ataxin-10	0,9	O-linked beta-N-acetylglucosamine transferase	Ataxin-10	26295(Tax:10116)	170821(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ataxin-10 interacts with O-linked_beta-N-acetylglucosamine_transferase in the brain .
9153230	0	O2	59,61	opaque-2	49,57	O2	opaque-2	542375(Tax:4577)	542375(Tax:4577)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Analysis of the methylation pattern of the maize opaque-2 -LRB- O2 -RRB- promoter and in vitro binding studies indicate that the O2 B-Zip protein and other endosperm factors can bind to methylated target sequences .
7093528	0	O2_and_H2O2	58,69	neuraminidase	11,24	O2 and H2O2	neuraminidase	28893	4758	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuraminidase on O2 consumption and release of O2_and_H2O2 from phagocytosing human polymorphonuclear leukocytes .
2360469	0	O6-MT	56,61	O6-methylguanine-DNA_methyltransferase	16,54	O6-MT	O6-methylguanine-DNA methyltransferase	25332(Tax:10116)	25332(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Linkage between O6-methylguanine-DNA_methyltransferase -LRB- O6-MT -RRB- activity and cellular resistance to antitumour nitrosoureas in cultured rat brain_tumour cell strains .
12483540	0	O6-Methylguanine-DNA_Methyltransferase	42,80	MGMT	82,86	O6-Methylguanine-DNA Methyltransferase	MGMT	4255	4255	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Frequent promoter hypermethylation of the O6-Methylguanine-DNA_Methyltransferase -LRB- MGMT -RRB- gene in testicular_cancer .
11536039	0	O6-alkylguanine_DNA_alkyltransferase	24,60	AGT	62,65	O6-alkylguanine DNA alkyltransferase	AGT	17314(Tax:10090)	17314(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of human O6-alkylguanine_DNA_alkyltransferase -LRB- AGT -RRB- prevents MNU induced lymphomas in heterozygous p53 deficient mice .
14647440	0	O6-methylguanine-DNA_methyltransferase	77,115	MGMT	117,121	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene expression in human cancer .
1635460	0	O6-methylguanine-DNA_methyltransferase	34,72	MGMT	74,78	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Chromosomal localization of human O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene by in situ hybridization .
2233795	0	O6-methylguanine-DNA_methyltransferase	15,53	MGMT	55,59	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The control of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- activity in mammalian cells : a pre-molecular view .
23387271	0	O6-methylguanine-DNA_methyltransferase	88,126	MGMT	128,132	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	-LSB- Bioinformatic analysis of potential post-translational modification sites of the human O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- protein -RSB- .
26261487	0	O6-methylguanine-DNA_methyltransferase	104,142	MGMT	144,148	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Overexpression of DNA_methyltransferase_1 -LRB- DNMT1 -RRB- protein in astrocytic_tumour and its correlation with O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- expression .
8565132	0	O6-methylguanine-DNA_methyltransferase	13,51	MGMT	53,57	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Targeting of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- activity by antimessenger oligonucleotide sensitizes CHO/Mex + transfected cells to mitozolomide .
8621235	0	O6-methylguanine-DNA_methyltransferase	21,59	MGMT	61,65	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Protective effect of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- on the cytotoxic and recombinogenic activity of different antineoplastic drugs .
9653449	0	O6-methylguanine-DNA_methyltransferase	47,85	MGMT	101,105	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
9653449	0	O6-methylguanine-DNA_methyltransferase	47,85	MGMT	87,91	O6-methylguanine-DNA methyltransferase	MGMT	4255	4255	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Repair of cyclobutane_pyrimidine_dimers in the O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus .
2360469	0	O6-methylguanine-DNA_methyltransferase	16,54	O6-MT	56,61	O6-methylguanine-DNA methyltransferase	O6-MT	25332(Tax:10116)	25332(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Linkage between O6-methylguanine-DNA_methyltransferase -LRB- O6-MT -RRB- activity and cellular resistance to antitumour nitrosoureas in cultured rat brain_tumour cell strains .
12503076	0	O6-methylguanine-DNA_methyltransferase	16,54	p53	147,150	O6-methylguanine-DNA methyltransferase	p53	4255	7157	Gene	Gene	START_ENTITY|dep|mutations mutations|nmod|END_ENTITY	DNA repair gene O6-methylguanine-DNA_methyltransferase : promoter hypermethylation associated with decreased expression and G : C to A : T mutations of p53 in brain_tumors .
12807758	0	O6-methylguanine-DNA_methyltransferase	32,70	p53	120,123	O6-methylguanine-DNA methyltransferase	p53	4255	7157	Gene	Gene	repair|dobj|START_ENTITY repair|nmod|mutations mutations|compound|END_ENTITY	Inactivation of DNA repair gene O6-methylguanine-DNA_methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal_squamous_cell_carcinoma .
17234766	0	O6-methylguanine-DNA_methyltransferase	0,38	p53	53,56	O6-methylguanine-DNA methyltransferase	p53	17314(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	O6-methylguanine-DNA_methyltransferase regulation by p53 in astrocytic cells .
18712569	0	O6-methylguanine-DNA_methyltransferase	15,53	p53	87,90	O6-methylguanine-DNA methyltransferase	p53	4255	7157	Gene	Gene	Association|nmod|START_ENTITY promoter|nsubj|Association promoter|nmod|occurrence occurrence|compound|END_ENTITY	Association of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- promoter methylation with p53 mutation occurrence in non-small cell lung_cancer with different histology , gender , and smoking status .
8616846	0	O6-methylguanine-DNA_methyltransferase	52,90	p53	10,13	O6-methylguanine-DNA methyltransferase	p53	4255	7157	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene suppresses|dobj|transcription suppresses|nsubj|END_ENTITY	Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA_methyltransferase gene .
9780001	0	O6-methylguanine-DNA_methyltransferase	53,91	p53	0,3	O6-methylguanine-DNA methyltransferase	p53	25332(Tax:10116)	301300(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- by DNA damaging agents .
7554086	0	O6-methylguanine_DNA_methyltransferase	48,86	MGMT	88,92	O6-methylguanine DNA methyltransferase	MGMT	4255	4255	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The role of mRNA stability and transcription in O6-methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- expression in Mer + human tumor cells .
8006031	0	O6-methylguanine_DNA_methyltransferase	51,89	MGMT	91,95	O6-methylguanine DNA methyltransferase	MGMT	4255	4255	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Graded methylation in the promoter and body of the O6-methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- gene correlates with MGMT expression in human glioma cells .
24716865	0	OASIS	0,5	chondroitin_6-O-sulfotransferase_1	16,50	OASIS	chondroitin 6-O-sulfotransferase 1	26427(Tax:10090)	53374(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	OASIS regulates chondroitin_6-O-sulfotransferase_1 gene transcription in the injured adult mouse cerebral cortex .
16164626	0	OAT	99,102	organic_anion_transporter	72,97	OAT	organic anion transporter	4942	4942	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Analyses of coding region polymorphisms in apical and basolateral human organic_anion_transporter -LRB- OAT -RRB- genes -LSB- OAT1 -LRB- NKT -RRB- , OAT2 , OAT3 , OAT4 , URAT -LRB- RST -RRB- -RSB- .
8495798	0	OAT	59,62	ornithine-delta-aminotransferase	25,57	OAT	ornithine-delta-aminotransferase	4942	4942	Gene	Gene	control|appos|START_ENTITY control|nmod|END_ENTITY	Translational control of ornithine-delta-aminotransferase -LRB- OAT -RRB- by estrogen .
1635292	0	OAT	48,51	ornithine_aminotransferase	20,46	OAT	ornithine aminotransferase	4942	4942	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human ornithine_aminotransferase -LRB- OAT -RRB- in OAT-deficient Chinese_hamster_ovary cells and fibroblasts of gyrate atrophy patient .
16164626	0	OAT1	111,115	OAT2	123,127	OAT1	OAT2	9356	10864	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	Analyses of coding region polymorphisms in apical and basolateral human organic_anion_transporter -LRB- OAT -RRB- genes -LSB- OAT1 -LRB- NKT -RRB- , OAT2 , OAT3 , OAT4 , URAT -LRB- RST -RRB- -RSB- .
16164626	0	OAT1	111,115	organic_anion_transporter	72,97	OAT1	organic anion transporter	9356	4942	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	Analyses of coding region polymorphisms in apical and basolateral human organic_anion_transporter -LRB- OAT -RRB- genes -LSB- OAT1 -LRB- NKT -RRB- , OAT2 , OAT3 , OAT4 , URAT -LRB- RST -RRB- -RSB- .
16164626	0	OAT2	123,127	OAT1	111,115	OAT2	OAT1	10864	9356	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	Analyses of coding region polymorphisms in apical and basolateral human organic_anion_transporter -LRB- OAT -RRB- genes -LSB- OAT1 -LRB- NKT -RRB- , OAT2 , OAT3 , OAT4 , URAT -LRB- RST -RRB- -RSB- .
16247710	0	OAT3	38,42	SLC22A8	44,51	OAT3	SLC22A8	9376	9376	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Pharmacokinetic significance of renal OAT3 -LRB- SLC22A8 -RRB- for anionic drug elimination in patients with mesangial_proliferative_glomerulonephritis .
23082789	0	OATP	60,64	organic_anion_transporting_polypeptide	20,58	OATP	organic anion transporting polypeptide	6579	6579	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Characterization of organic_anion_transporting_polypeptide -LRB- OATP -RRB- expression and its functional contribution to the uptake of substrates in human hepatocytes .
15970799	0	OATP-C	40,46	SLCO1B1	31,38	OATP-C	SLCO1B1	10599	10599	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of SLCO1B1 -LRB- OATP-C -RRB- variants , SLCO1B1 * 5 , SLCO1B1 * 15 and SLCO1B1 * 15 + C1007G , by using transient expression systems of HeLa and HEK293 cells .
12566240	0	OATP-E	56,62	organic_anion_transporting_polypeptide_E	14,54	OATP-E	organic anion transporting polypeptide E	28231	28231	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of organic_anion_transporting_polypeptide_E -LRB- OATP-E -RRB- in human placenta .
25387129	0	OATP1A2	89,96	Organic_Anion_Transporting_Polypeptide_1A2	45,87	OATP1A2	Organic Anion Transporting Polypeptide 1A2	6579	6579	Gene	Gene	Domain|appos|START_ENTITY Domain|nmod|END_ENTITY	Putative Transmembrane Domain 6 of the Human Organic_Anion_Transporting_Polypeptide_1A2 -LRB- OATP1A2 -RRB- Influences Transporter Substrate Binding , Protein Trafficking , and Quality Control .
24970118	0	OATP1A2	68,75	organic_anion_transporting_polypeptide_1A2	24,66	OATP1A2	organic anion transporting polypeptide 1A2	6579	6579	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Molecular regulation of organic_anion_transporting_polypeptide_1A2 -LRB- OATP1A2 -RRB- by taurocholic_acid in Bewo Cells .
19884908	0	OATP1B1	26,33	SLCO1B1	17,24	OATP1B1	SLCO1B1	10599	10599	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The influence of SLCO1B1 -LRB- OATP1B1 -RRB- gene polymorphisms on response to statin therapy .
26336578	0	OATP1B1	37,44	miR-511	8,15	OATP1B1	miR-511	10599	574445	Gene	Gene	Expression|compound|START_ENTITY Regulation|nmod|Expression Role|nmod|Regulation Role|nmod|END_ENTITY	Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty_Acid .
21665049	0	OATP1B1	54,61	organic_anion-transporting_polypeptide_1B1	10,52	OATP1B1	organic anion-transporting polypeptide 1B1	10599	10599	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Effect of organic_anion-transporting_polypeptide_1B1 -LRB- OATP1B1 -RRB- polymorphism on the single - and multiple-dose pharmacokinetics of enalapril in healthy Chinese adult men .
25418376	0	OATP1B1	62,69	organic_anion_transporting_polypeptide_1B1	18,60	OATP1B1	organic anion transporting polypeptide 1B1	10599	10599	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role of organic_anion_transporting_polypeptide_1B1 -LRB- OATP1B1 -RRB- in the selective hepatic uptake of hematoporphyrin_monomethyl_ether isomers .
16702737	0	OATP1B3	55,62	OATP8	48,53	OATP1B3	OATP8	28234	28234	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms and linkage disequilibrium of the OATP8 -LRB- OATP1B3 -RRB- gene in Japanese subjects .
23924606	0	OATP1B3	132,139	hypoxia_inducible_factor-1a	8,35	OATP1B3	hypoxia inducible factor-1a	28234	3091	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of hypoxia_inducible_factor-1a in the regulation of the cancer-specific variant of organic_anion_transporting_polypeptide_1B3 -LRB- OATP1B3 -RRB- , in colon_and_pancreatic_cancer .
16489487	0	OATP2B1	26,33	SLCO2B1	35,42	OATP2B1	SLCO2B1	11309	11309	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of human OATP2B1 -LRB- SLCO2B1 -RRB- gene promoter regulation .
19285480	0	OATP2B1	55,62	organic_anion_transporting_polypeptide	16,54	OATP2B1	organic anion transporting polypeptide	11309	6579	Gene	Gene	START_ENTITY|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of organic_anion_transporting_polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells .
16702737	0	OATP8	48,53	OATP1B3	55,62	OATP8	OATP1B3	28234	28234	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms and linkage disequilibrium of the OATP8 -LRB- OATP1B3 -RRB- gene in Japanese subjects .
16373339	0	OAZ	0,3	bone_morphogenetic_protein	14,40	OAZ	bone morphogenetic protein	4946	649	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	OAZ regulates bone_morphogenetic_protein signaling through Smad6 activation .
10792465	0	OAZ-t	89,94	ornithine_decarboxylase	55,78	OAZ-t	ornithine decarboxylase	51686	4953	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and characterization of testis specific ornithine_decarboxylase antizyme -LRB- OAZ-t -RRB- gene : expression in haploid germ cells and polyamine-induced frameshifting .
19665393	0	OB-R	108,112	leptin	114,120	OB-R	leptin	3953	3952	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Expression patterns of leptin_receptor -LRB- OB-R -RRB- isoforms and direct in vitro effects of recombinant leptin on OB-R , leptin expression and cytokine secretion by human hematopoietic malignant cells .
19665393	0	OB-R	108,112	leptin	98,104	OB-R	leptin	3953	3952	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Expression patterns of leptin_receptor -LRB- OB-R -RRB- isoforms and direct in vitro effects of recombinant leptin on OB-R , leptin expression and cytokine secretion by human hematopoietic malignant cells .
15240518	0	OB-R	51,55	leptin_and_leptin_receptor	23,49	OB-R	leptin and leptin receptor	3953	3952;3953	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of leptin_and_leptin_receptor -LRB- OB-R -RRB- in human breast_cancer .
17006991	0	OB-R	50,54	leptin_and_leptin_receptor	22,48	OB-R	leptin and leptin receptor	3953	3952;3953	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of leptin_and_leptin_receptor -LRB- OB-R -RRB- in human gastric_cancer .
10526147	0	OBCAM	55,60	opioid-binding_cell_adhesion_molecule	16,53	OBCAM	opioid-binding cell adhesion molecule	116597(Tax:10116)	116597(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of opioid-binding_cell_adhesion_molecule -LRB- OBCAM -RRB- in adult rat brain .
10960687	0	OBCAM	67,72	opioid-binding_cell_adhesion_molecule	28,65	OBCAM	opioid-binding cell adhesion molecule	116597(Tax:10116)	116597(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of opioid-binding_cell_adhesion_molecule -LRB- OBCAM -RRB- in rat brain .
16861304	0	OBF-1	68,73	Spi-B	15,20	OBF-1	OCA-B	18985(Tax:10090)	18985(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The Ets factor Spi-B is a direct critical target of the coactivator OBF-1 .
26970073	0	OBP	76,79	odorant-binding_protein	51,74	OBP	odorant-binding protein	29991	29991	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Genome-wide identification and characterization of odorant-binding_protein -LRB- OBP -RRB- genes in the malaria vector Anopheles sinensis -LRB- Diptera : Culicidae -RRB- .
19648609	0	OB_fold-containing_protein_1	0,28	Stn1	63,67	OB fold-containing protein 1	TRF2	79991	7014	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	OB_fold-containing_protein_1 -LRB- OBFC1 -RRB- , a human homolog of yeast Stn1 , associates with TPP1 and is implicated in telomere length regulation .
19648609	0	OB_fold-containing_protein_1	0,28	TPP1	85,89	OB fold-containing protein 1	TPP1	79991	855188(Tax:4932)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	OB_fold-containing_protein_1 -LRB- OBFC1 -RRB- , a human homolog of yeast Stn1 , associates with TPP1 and is implicated in telomere length regulation .
18418398	0	OC2	28,31	T-bet	54,59	OC2	T-bet	9480	30009	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells .
7805878	0	OC2	87,90	cathepsin_O	27,38	OC2	cathepsin O	100009334(Tax:9986)	1519	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of human cathepsin_O , a novel endoproteinase and homologue of rabbit OC2 .
17709512	0	OCA-B	40,45	ERdj3	18,23	OCA-B	ERdj3	5450	51726	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of ERdj3 and OBF-1 / BOB-1 / OCA-B as direct targets of XBP-1 during plasma cell differentiation .
17709512	0	OCA-B	40,45	XBP-1	67,72	OCA-B	XBP-1	5450	7494	Gene	Gene	START_ENTITY|nmod|targets targets|nmod|END_ENTITY	Identification of ERdj3 and OBF-1 / BOB-1 / OCA-B as direct targets of XBP-1 during plasma cell differentiation .
11041207	0	OCA1	56,60	tyrosinase	4,14	OCA1	tyrosinase	7299	7299	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The tyrosinase gene and oculocutaneous_albinism_type_1 -LRB- OCA1 -RRB- : A model for understanding the molecular biology of melanin formation .
23112997	0	OCA1A	52,57	Oculocutaneous_Albinism_Type1A	20,50	OCA1A	Oculocutaneous Albinism Type1A	7299	7299	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Genetic Analysis of Oculocutaneous_Albinism_Type1A -LRB- OCA1A -RRB- in an Iranian Family .
18172690	0	OCA2	147,151	HERC2	125,130	OCA2	HERC2	4948	8924	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression .
9281346	0	OCI-5	14,19	glypican_3	20,30	OCI-5	glypican 3	25236(Tax:10116)	25236(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of OCI-5 / glypican_3 during intestinal morphogenesis : regulation by cell shape in intestinal epithelial cells .
9714833	0	OCIF	61,65	osteoclastogenesis_inhibitory_factor	23,59	OCIF	osteoclastogenesis inhibitory factor	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the mouse osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- gene and its expression in embryogenesis .
18465072	0	OCIL	63,67	osteoclast_inhibitory_lectin	33,61	OCIL	osteoclast inhibitory lectin	29121	29121	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Asn19Lys substitution in the osteoclast_inhibitory_lectin -LRB- OCIL -RRB- gene is associated with a reduction of bone_mineral_density in postmenopausal women .
22677019	0	OCN	35,38	insulinlike_growth_factor-I	53,80	OCN	insulinlike growth factor-I	632	3479	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	The dynamic changes of circulating OCN + cells versus insulinlike_growth_factor-I during primary healing of orthognathic surgeries .
26725203	0	OCRL	85,89	Rab35	0,5	OCRL	Rab35	4952	11021	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|compound|END_ENTITY	Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes .
7474892	0	OCT	84,87	ornithine_carbamoyltransferase	52,82	OCT	ornithine carbamoyltransferase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of two new aberrant splicings in the ornithine_carbamoyltransferase -LRB- OCT -RRB- gene in two patients with early and late onset OCT_deficiency .
16116232	0	OCT-1	100,105	C-reactive_protein	46,64	OCT-1	C-reactive protein	5451	1401	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of basal and induced expression of C-reactive_protein through an overlapping element for OCT-1 and NF-kappaB on the proximal promoter .
20960024	0	OCT1	24,28	islet_1	39,46	OCT1	islet 1	18986(Tax:10090)	16392(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	POU homeodomain protein OCT1 modulates islet_1 expression during cardiac differentiation of P19CL6 cells .
24399729	0	OCT1	64,68	organic_cation_transporter_1	34,62	OCT1	organic cation transporter 1	6580	6580	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucocorticoid_receptor regulates organic_cation_transporter_1 -LRB- OCT1 , SLC22A1 -RRB- expression via HNF4a upregulation in primary human hepatocytes .
23876341	0	OCT2	35,39	MATE1	83,88	OCT2	MATE1	6582	55244	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of organic cation transporter OCT2 and multidrug and toxin extrusion proteins MATE1 and MATE2-K for transport and drug interactions of the antiviral lamivudine .
21523786	0	OCT2	68,72	SLC22A2	59,66	OCT2	SLC22A2	6582	6582	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interindividual differences in placental expression of the SLC22A2 -LRB- OCT2 -RRB- gene : relationship to epigenetic variations in the 5 ' - upstream regulatory region .
12841847	0	OCT3	28,32	fibroblast_growth_factor-4	78,104	OCT3	fibroblast growth factor-4	5460	2249	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast_growth_factor-4 -LRB- FGF-4 -RRB- in human breast_cancer cells .
20689077	0	OCT3/4	111,117	KLF4	11,15	OCT3/4	KLF4	5460	9314	Gene	Gene	pluripotency|nmod|START_ENTITY reprogramming|xcomp|pluripotency allows|advcl|reprogramming allows|nsubj|expression expression|compound|END_ENTITY	Endogenous KLF4 expression in human fetal endothelial cells allows for reprogramming to pluripotency with just OCT3/4 and SOX2 -- brief report .
23433354	0	OCT4	0,4	BIRC5	15,20	OCT4	BIRC5	5460	332	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular_carcinoma .
25684227	0	OCT4	42,46	BRD4	22,26	OCT4	BRD4	5460	23476	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	The BET Family Member BRD4 Interacts with OCT4 and Regulates Pluripotency Gene Expression .
16733205	0	OCT4	0,4	CD30	20,24	OCT4	CD30	5460	943	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|END_ENTITY	OCT4 is superior to CD30 in the diagnosis of metastatic embryonal_carcinomas after chemotherapy .
25911324	0	OCT4	0,4	ERK1/2	85,91	OCT4	ERK1/2	5460	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	OCT4 mediates FSH-induced epithelial-mesenchymal transition and invasion through the ERK1/2 signaling pathway in epithelial_ovarian_cancer .
24971534	0	OCT4	30,34	ESE-1	67,72	OCT4	ESE-1	5460	1999	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of OCT4 by the ETS transcription factor ESE-1 in NCCIT human embryonic_carcinoma cells .
26639784	0	OCT4	24,28	GLUT3	0,5	OCT4	GLUT3	5460	6515	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells .
24792165	0	OCT4	54,58	KLF4	77,81	OCT4	KLF4	5460	9314	Gene	Gene	START_ENTITY|appos|SOX2 SOX2|appos|END_ENTITY	Engineered zinc-finger transcription factors activate OCT4 -LRB- POU5F1 -RRB- , SOX2 , KLF4 , c-MYC -LRB- MYC -RRB- and miR302/367 .
19409607	0	OCT4	23,27	MicroRNA-145	0,12	OCT4	MicroRNA-145	5460	406937	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-145 regulates OCT4 , SOX2 , and KLF4 and represses pluripotency in human embryonic stem cells .
20410807	0	OCT4	53,57	NANOG	59,64	OCT4	NANOG	5460	79923	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
24983502	0	OCT4	30,34	PEA3	67,71	OCT4	PEA3	5460	2118	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic_carcinoma cells .
22019428	0	OCT4	28,32	POU5F1	20,26	OCT4	POU5F1	5460	5460	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of POU5F1 -LRB- OCT4 -RRB- gene and its promoter in buffalo ESC-like cells identifies multiple transcription start sites and expression of four pseudogenes .
20410807	0	OCT4	53,57	SALL4	46,51	OCT4	SALL4	5460	57167	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	OCT4	53,57	SOX2	66,70	OCT4	SOX2	5460	6657	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
26762895	0	OCT4	9,13	SOX2	65,69	OCT4	SOX2	5460	6657	Gene	Gene	transcriptional|nsubj|START_ENTITY transcriptional|nmod|END_ENTITY	Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming .
20410807	0	OCT4	53,57	UTF1	72,76	OCT4	UTF1	5460	8433	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
19274063	0	OCT4	50,54	WWP2	0,4	OCT4	WWP2	5460	11060	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	WWP2 promotes degradation of transcription factor OCT4 in human embryonic_stem cells .
25754111	0	OCT4	15,19	YAP1	0,4	OCT4	YAP1	100846986	22601(Tax:10090)	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and Vascular Mimicry of Stem-like Cells .
23000165	0	OCT4	14,18	liver_receptor_homolog-1	38,62	OCT4	liver receptor homolog-1	5460	2494	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of OCT4 gene expression by liver_receptor_homolog-1 in human embryonic_carcinoma cells .
15832501	0	OCTN1	15,20	SLC22A4	22,29	OCTN1	SLC22A4	6583	6583	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of OCTN1 -LRB- SLC22A4 -RRB- in pH-dependent transport of organic cations .
15523054	0	OCTN2	78,83	PDZK1	0,5	OCTN2	PDZK1	6584	5174	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2 .
16896066	0	OCTN2	96,101	PDZK2	20,25	OCTN2	PDZK2	6584	79849	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	PDZ adaptor protein PDZK2 stimulates transport activity of organic cation/carnitine transporter OCTN2 by modulating cell surface expression .
25299939	0	OCTN2	60,65	PPARa	74,79	OCTN2	PPARa	20520(Tax:10090)	281992(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of the human , porcine and bovine OCTN2 gene by PPARa via a conserved PPRE located in intron 1 .
26370461	0	OCTN2	37,42	SLC22A5	44,51	OCTN2	SLC22A5	6584	6584	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Organic cation/carnitine transporter OCTN2 -LRB- SLC22A5 -RRB- -207 C > G -LRB- rs2631367 -RRB- polymorphism is not associated with male_infertility .
21641380	0	OCTN2	73,78	organic_cation_transporter_novel_type_2	32,71	OCTN2	organic cation transporter novel type 2	6584	6584	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Selective regulation of cardiac organic_cation_transporter_novel_type_2 -LRB- OCTN2 -RRB- in dilated_cardiomyopathy .
19819229	0	OCTN2	6,11	peroxisome_proliferator-activated_receptor_alpha	37,85	OCTN2	peroxisome proliferator-activated receptor alpha	20518(Tax:10090)	19013(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Mouse OCTN2 is directly regulated by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- via a PPRE located in the first intron .
20558736	0	OCTN2	6,11	peroxisome_proliferator-activated_receptor_gamma	47,95	OCTN2	peroxisome proliferator-activated receptor gamma	6584	5468	Gene	Gene	expression|compound|START_ENTITY up-regulated|nsubj|expression up-regulated|nmod|END_ENTITY	Colon OCTN2 gene expression is up-regulated by peroxisome_proliferator-activated_receptor_gamma in humans and mice and contributes to local and systemic carnitine homeostasis .
18472969	0	ODAM	57,61	odontogenic_ameloblast-associated_protein	14,55	ODAM	odontogenic ameloblast-associated protein	54959	54959	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of odontogenic_ameloblast-associated_protein -LRB- ODAM -RRB- in dental and other epithelial_neoplasms .
8149836	0	ODC	25,28	Ornithine_decarboxylase	0,23	ODC	Ornithine decarboxylase	4953	4953	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Ornithine_decarboxylase -LRB- ODC -RRB- levels in children with reflux_esophagitis .
11149424	0	ODC	155,158	ZBP-89	221,227	ODC	ZBP-89	18263(Tax:10090)	22661(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY inhibition|nmod|activity receptor|nmod|inhibition receptor|parataxis|role role|nmod|END_ENTITY	Retinoic_acid -LRB- RA -RRB- receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase -LRB- ODC -RRB- activity by retinoids : a potential role for trans-RA-induced ZBP-89 in ODC inhibition .
11149424	0	ODC	231,234	ZBP-89	221,227	ODC	ZBP-89	18263(Tax:10090)	22661(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Retinoic_acid -LRB- RA -RRB- receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase -LRB- ODC -RRB- activity by retinoids : a potential role for trans-RA-induced ZBP-89 in ODC inhibition .
3277634	0	ODC	27,30	c-fos	16,21	ODC	c-fos	24609(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene .
11149424	0	ODC	155,158	ornithine_decarboxylase	130,153	ODC	ornithine decarboxylase	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Retinoic_acid -LRB- RA -RRB- receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase -LRB- ODC -RRB- activity by retinoids : a potential role for trans-RA-induced ZBP-89 in ODC inhibition .
1573975	0	ODC	43,46	ornithine_decarboxylase	18,41	ODC	ornithine decarboxylase	4953	4953	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Polyamine levels , ornithine_decarboxylase -LRB- ODC -RRB- activity , and ODC-mRNA expression in normal and cancerous human colonocytes .
19076071	0	ODC	66,69	ornithine_decarboxylase	41,64	ODC	ornithine decarboxylase	4953	4953	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Antizyme_3 inhibits polyamine uptake and ornithine_decarboxylase -LRB- ODC -RRB- activity , but does not stimulate ODC degradation .
19440938	0	ODC	73,76	ornithine_decarboxylase	48,71	ODC	ornithine decarboxylase	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of exposure to DAMPS and GSM signals on ornithine_decarboxylase -LRB- ODC -RRB- activity : I. L-929 mouse fibroblasts .
19440939	0	ODC	73,76	ornithine_decarboxylase	48,71	ODC	ornithine decarboxylase	4953	4953	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of exposure to DAMPS and GSM signals on ornithine_decarboxylase -LRB- ODC -RRB- activity : II .
2304344	0	ODC	75,78	ornithine_decarboxylase	50,73	ODC	ornithine decarboxylase	4953	4953	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Absence of effect of supplemental oral calcium on ornithine_decarboxylase -LRB- ODC -RRB- activity in colonic mucosae of healthy individuals with a family history of colorectal_cancer .
7537363	0	ODC	64,67	ornithine_decarboxylase	39,62	ODC	ornithine decarboxylase	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcription elongation of the murine ornithine_decarboxylase -LRB- ODC -RRB- gene is regulated in vitro at two downstream elements by different attenuation mechanisms .
7543894	0	ODC	41,44	ornithine_decarboxylase	16,39	ODC	ornithine decarboxylase	24609(Tax:10116)	24609(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of ornithine_decarboxylase -LRB- ODC -RRB- in the cochlea of the immature rat .
7591239	0	ODC	54,57	ornithine_decarboxylase	29,52	ODC	ornithine decarboxylase	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Life-long over-expression of ornithine_decarboxylase -LRB- ODC -RRB- gene in transgenic_mice does not lead to generally enhanced tumorigenesis or neuronal_degeneration .
9162900	0	ODC	129,132	ornithine_decarboxylase	104,127	ODC	ornithine decarboxylase	24609(Tax:10116)	24609(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine_decarboxylase -LRB- ODC -RRB- gene .
964206	0	ODC	46,49	ornithine_decarboxylase	21,44	ODC	ornithine decarboxylase	24609(Tax:10116)	24609(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of uterine ornithine_decarboxylase -LRB- ODC -RRB- by antiestrogens .
3418748	0	ODC-AZ	58,64	ornithine_decarboxylase_antizyme	24,56	ODC-AZ	ornithine decarboxylase antizyme	25502(Tax:10116)	25502(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Chloroform induction of ornithine_decarboxylase_antizyme -LRB- ODC-AZ -RRB- in male rat liver .
26963840	0	ODC_Antizyme_Inhibitor_2	14,38	AZIN2	40,45	ODC Antizyme Inhibitor 2	AZIN2	113451	113451	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ODC_Antizyme_Inhibitor_2 -LRB- AZIN2 -RRB- in Human Secretory Cells and Tissues .
21457372	0	OFP4	23,27	KNAT7	46,51	OFP4	KNAT7	837202(Tax:3702)	842602(Tax:3702)	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	OVATE FAMILY PROTEIN4 -LRB- OFP4 -RRB- interaction with KNAT7 regulates secondary cell wall formation in Arabidopsis_thaliana .
11006485	1	OFQ	149,152	orphanin_FQ	136,147	OFQ	orphanin FQ	5368	5368	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	_ 5 -RSB- decan-4-one , a potent and selective orphanin_FQ -LRB- OFQ -RRB- receptor agonist with anxiolytic-like properties .
10385636	0	OGDC-E1	91,98	PDC-E2	34,40	OGDC-E1	PDC-E2	4967	1737	Gene	Gene	detection|amod|START_ENTITY detection|nmod|END_ENTITY	In situ nucleic acid detection of PDC-E2 , BCOADC-E2 , OGDC-E2 , PDC-E1alpha , BCOADC-E1alpha , OGDC-E1 , and the E3 binding protein -LRB- protein X -RRB- in primary_biliary_cirrhosis .
11113537	0	OGFr	82,86	opioid_growth_factor_receptor	51,80	OGFr	opioid growth factor receptor	72075(Tax:10090)	72075(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization and distribution of the opioid_growth_factor_receptor -LRB- OGFr -RRB- in mouse .
15841414	0	OGG1	44,48	8-oxoguanine_DNA_glycosylase	14,42	OGG1	8-oxoguanine DNA glycosylase	4968	4968	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of 8-oxoguanine_DNA_glycosylase -LRB- OGG1 -RRB- in Parkinson 's _ disease and related neurodegenerative_disorders .
23368532	0	OGG1	95,99	8-oxoguanine_glycosylase_1	67,93	OGG1	8-oxoguanine glycosylase 1	4968	4968	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Is there any association between the Ser326Cys polymorphism of the 8-oxoguanine_glycosylase_1 -LRB- OGG1 -RRB- gene and risk of colon_polyp_and_abnormal_glucose_tolerance in acromegaly patients ?
20656472	0	OGG1	82,86	AMPK	109,113	OGG1	AMPK	4968	5562	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Novel mechanism of reducing tumourigenesis : upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition .
22306120	0	OGG1	42,46	APE1	48,52	OGG1	APE1	4968	328	Gene	Gene	XRCC1|compound|START_ENTITY XRCC1|appos|END_ENTITY	Genetic polymorphisms in DNA repair genes OGG1 , APE1 , XRCC1 , and XPD and the risk of age-related cataract .
11978483	0	OGG1	25,29	MMH	30,33	OGG1	MMH	4968	4968	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of mammalian OGG1 -LRB- MMH -RRB- in excision of the 8-hydroxyguanine residue in DNA .
23697596	0	OGG1	38,42	NRF2	47,51	OGG1	NRF2	81528(Tax:10116)	83619(Tax:10116)	Gene	Gene	START_ENTITY|nmod|induction induction|compound|END_ENTITY	Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast_cancer .
19506022	0	OGG1	76,80	RAD52	26,31	OGG1	RAD52	4968	5893	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells .
11454679	0	OGG1	102,106	oxoguanine_dna_glycosylase	74,100	OGG1	oxoguanine dna glycosylase	18294(Tax:10090)	18294(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine_dna_glycosylase -LRB- OGG1 -RRB- gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice .
18302504	0	OGR1	93,97	Cyclooxygenase-2	0,16	OGR1	Cyclooxygenase-2	8111	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 expression and prostaglandin_E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line .
16182253	0	OGT	46,49	Ataxin-10	0,9	OGT	Ataxin-10	108155(Tax:10090)	54138(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ataxin-10 interacts with O-GlcNAc transferase OGT in pancreatic beta cells .
23353889	0	OGT	66,69	TET2	0,4	OGT	TET2	108155(Tax:10090)	214133(Tax:10090)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS .
17431671	0	OLIG2	26,31	ID2	37,40	OLIG2	ID2	10215	3398	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Predominant expression of OLIG2 over ID2 in oligodendroglial_tumors .
16103065	0	OLIG2	0,5	LMO1	91,95	OLIG2	LMO1	50913(Tax:10090)	109594(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	OLIG2 -LRB- BHLHB1 -RRB- , a bHLH transcription factor , contributes to leukemogenesis in concert with LMO1 .
19477230	0	OLIG2	79,84	oligodendrocyte_lineage_transcription_factor_2	31,77	OLIG2	oligodendrocyte lineage transcription factor 2	10215	10215	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence that variation in the oligodendrocyte_lineage_transcription_factor_2 -LRB- OLIG2 -RRB- gene is associated with psychosis in Alzheimer 's _ disease .
18054331	0	OLR-1	54,59	LDL_receptor	35,47	OLR-1	LDL receptor	4973	3949	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	The G501C polymorphism of oxidized LDL_receptor gene -LSB- OLR-1 -RSB- is associated with susceptibility and serum C-reactive_protein concentration in Chinese essential hypertensives .
12646194	0	OLR1	28,32	LDL_receptor	9,21	OLR1	LDL receptor	4973	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Oxidized LDL_receptor gene -LRB- OLR1 -RRB- is associated with the risk of myocardial_infarction .
17022953	0	OLR1	50,54	LDL_receptor	31,43	OLR1	LDL receptor	4973	3949	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	G501C polymorphism of oxidized LDL_receptor gene -LRB- OLR1 -RRB- and ischemic_stroke .
19580419	0	OMgp	92,96	oligodendrocyte_myelin_glycoprotein	55,90	OMgp	oligodendrocyte myelin glycoprotein	450224(Tax:10116)	450224(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Temporospatial expression and cellular localization of oligodendrocyte_myelin_glycoprotein -LRB- OMgp -RRB- after traumatic spinal_cord_injury in adult rats .
11527145	0	OP-1	12,16	BMP-7	6,11	OP-1	BMP-7	655	655	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Human BMP-7 / OP-1 induces the growth and differentiation of adipocytes and osteoblasts in bone marrow stromal cell cultures .
24086840	0	OP-1	41,45	Osteogenic_Protein-1	19,39	OP-1	Osteogenic Protein-1	655	655	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of the Osteogenic_Protein-1 -LRB- OP-1 -RRB- with Age , Cartilage metabolic Markers and Antioxidants in the Osteoarthritic Patients of Sikkim .
15509649	0	OPA1	0,4	mitofusin_1	14,25	OPA1	mitofusin 1	4976	55669	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	OPA1 requires mitofusin_1 to promote mitochondrial fusion .
16995820	0	OPG	42,45	Adiponectin	0,11	OPG	Adiponectin	4982	9370	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway .
22579611	0	OPG	50,53	CD9	83,86	OPG	CD9	18383(Tax:10090)	12527(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Bisphosphonate - and statin-induced enhancement of OPG expression and inhibition of CD9 , M-CSF , and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2 .
27074164	0	OPG	46,49	IL-10	11,16	OPG	IL-10	4982	3586	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of IL-10 and glucose on expression of OPG and RANKL in human periodontal ligament fibroblasts .
20225238	0	OPG	63,66	IL-1beta	10,18	OPG	IL-1beta	4982	3553	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of IL-1beta , PGE -LRB- 2 -RRB- , and TGF-beta1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts .
15632471	0	OPG	63,66	Osteoclastogenesis_Inhibitory_Factor	1,37	OPG	Osteoclastogenesis inhibitory factor	4982	4982	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	-LSB- Osteoclastogenesis_Inhibitory_Factor -LRB- OCIF -RRB- / Osteoprotegerin -LRB- OPG -RRB- as a new therapeutic agent for osteoporosis -RSB- .
16155791	0	OPG	17,20	Osteoprotegerin	0,15	OPG	Osteoprotegerin	4982	4982	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- expression by breast_cancer cells in vitro and breast_tumours in vivo -- a role in tumour cell survival ?
22210270	0	OPG	0,3	RANK	32,36	OPG	RANK	18383(Tax:10090)	21934(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	OPG inhibits gene expression of RANK and CAII in mouse osteoclast-like cell .
16798863	0	OPG	19,22	RANKL	12,17	OPG	RANKL	4982	8600	Gene	Gene	ratio|compound|START_ENTITY Increase|dep|ratio Increase|nmod|END_ENTITY	Increase in RANKL : OPG ratio in synovia of patients with temporomandibular_joint_disorder .
16995820	0	OPG	42,45	RANKL	23,28	OPG	RANKL	4982	8600	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway .
20560139	0	OPG	12,15	RANKL	43,48	OPG	RANKL	4982	8600	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis .
23241117	0	OPG	44,47	TNF-alpha	27,36	OPG	TNF-alpha	4982	7124	Gene	Gene	RANKL|appos|START_ENTITY RANKL|compound|END_ENTITY	Changes in serum levels of TNF-alpha , IL-6 , OPG , RANKL and their correlation with radiographic and clinical assessment in fragility_fractures and high energy fractures .
12070273	0	OPG	33,36	osteoprotegerin	16,31	OPG	osteoprotegerin	25341(Tax:10116)	25341(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of osteoprotegerin -LRB- OPG -RRB- on bone surfaces and cement lines in rat tibia .
15042606	0	OPG	23,26	osteoprotegerin	6,21	OPG	osteoprotegerin	4982	4982	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum osteoprotegerin -LRB- OPG -RRB- levels are associated with disease progression and response to androgen ablation in patients with prostate_cancer .
15241009	0	OPG	30,33	osteoprotegerin	13,28	OPG	osteoprotegerin	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of osteoprotegerin -LRB- OPG -RRB- on resorption of heterotopically induced ossicle .
15775414	0	OPG	62,65	osteoprotegerin	45,60	OPG	osteoprotegerin	4982	4982	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- -RSB- .
16464170	0	OPG	25,28	osteoprotegerin	8,23	OPG	osteoprotegerin	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of osteoprotegerin -LRB- OPG -RRB- in cancer .
17453373	0	OPG	139,142	osteoprotegerin	122,137	OPG	osteoprotegerin	4982	4982	Gene	Gene	axis|appos|START_ENTITY axis|compound|END_ENTITY	Abnormal bone remodeling process is due to an imbalance in the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- axis in patients with solid tumors metastatic to the skeleton .
19058561	0	OPG	30,33	osteoprotegerin	13,28	OPG	osteoprotegerin	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of osteoprotegerin -LRB- OPG -RRB- on experimentally induced ectopic bone .
21678294	0	OPG	32,35	osteoprotegerin	15,30	OPG	osteoprotegerin	4982	4982	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The effects of osteoprotegerin -LRB- OPG -RRB- gene polymorphism in patients with ischaemic_heart_disease on the morphology of coronary arteries and bone_mineral_density .
23277172	0	OPG	27,30	osteoprotegerin	10,25	OPG	osteoprotegerin	4982	4982	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TRAIL and osteoprotegerin -LRB- OPG -RRB- expression in bladder urothelial_carcinoma : correlation with clinicopathological parameters and prognosis .
23304691	0	OPG	29,32	osteoprotegerin	12,27	OPG	osteoprotegerin	4982	4982	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of osteoprotegerin -LRB- OPG -RRB- gene polymorphism in Iranian patients with chronic_periodontitis and peri-implantitis .
10225954	0	OPGL	32,36	osteoprotegerin	15,30	OPGL	osteoprotegerin	117516(Tax:10116)	25341(Tax:10116)	Gene	Gene	ligand|appos|START_ENTITY ligand|nmod|END_ENTITY	The ligand for osteoprotegerin -LRB- OPGL -RRB- directly activates mature osteoclasts .
12932438	0	OPHN1	23,28	RhoGAP	4,10	OPHN1	RhoGAP	4983	392	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The RhoGAP activity of OPHN1 , a new F-actin-binding protein , is negatively controlled by its amino-terminal domain .
21215700	0	OPN	0,3	CD44	60,64	OPN	CD44	6696	960	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	OPN promotes survival of activated T cells by up-regulating CD44 in patients with oral_lichen_planus .
25009318	0	OPN	36,39	CD44	58,62	OPN	CD44	6696	960	Gene	Gene	osteopontin|appos|START_ENTITY association|nmod|osteopontin END_ENTITY|nsubj|association	Genetic association of osteopontin -LRB- OPN -RRB- and its receptor CD44 genes with susceptibility to Chinese gastric_cancer patients .
25522167	0	OPN	0,3	FoxM1	12,17	OPN	FoxM1	6696	2305	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	OPN Induces FoxM1 Expression and Localization through ERK_1 / 2 , AKT , and p38 Signaling Pathway in HEC-1A Cells .
19901966	0	OPN	96,99	IFITM3	81,87	OPN	IFITM3	6696	361673(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Interferon-induced transmembrane 3 binds osteopontin in vitro : expressed in vivo IFITM3 reduced OPN expression .
23359766	0	OPN	28,31	Osteopontin	15,26	OPN	Osteopontin	6696	6696	Gene	Gene	Expressions|appos|START_ENTITY Expressions|nmod|END_ENTITY	Expressions of Osteopontin -LRB- OPN -RRB- , a b3 and Pim-1 Associated with Poor Prognosis in Non-small_Cell_Lung_Cancer -LRB- NSCLC -RRB- .
12753549	0	OPN	27,30	osteopontin	14,25	OPN	osteopontin	281499(Tax:9913)	281499(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of osteopontin -LRB- OPN -RRB- mRNA in bovine ovarian follicles and corpora lutea .
18835636	0	OPN	23,26	osteopontin	10,21	OPN	osteopontin	281499(Tax:9913)	281499(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of osteopontin -LRB- OPN -RRB- on in vitro embryo development in cattle .
20010486	0	OPN	73,76	osteopontin	60,71	OPN	osteopontin	397087(Tax:9823)	397087(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The study of polymorphism within the promoter region of the osteopontin -LRB- OPN -RRB- gene in sows .
20219412	0	OPN	32,35	osteopontin	19,30	OPN	osteopontin	6696	6696	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The implication of osteopontin -LRB- OPN -RRB- expression and genetic polymorphisms of OPN promoter in oral carcinogenesis .
23352191	0	OPN	36,39	osteopontin	24,35	OPN	osteopontin	6696	6696	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Placental expression of osteopontin -LRB- OPN -RRB- in monochorionic twins with discordant growth .
26592666	0	OPN	57,60	osteopontin	44,55	OPN	osteopontin	6696	6696	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of glucose-stimulated osteopontin -LRB- OPN -RRB- expression in diabetic kidney .
22991144	0	OPN3	15,19	Encephalopsin	0,13	OPN3	Encephalopsin	13603(Tax:10090)	13603(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Encephalopsin -LRB- OPN3 -RRB- protein abundance in the adult mouse brain .
15608558	0	OPRK1	54,59	kappa_opioid_receptor	26,47	OPRK1	kappa opioid receptor	4986	4986	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Redefinition of the human kappa_opioid_receptor gene -LRB- OPRK1 -RRB- structure and association of haplotypes with opiate_addiction .
17373729	0	OPRK1	34,39	kappa_opioid_receptor	6,27	OPRK1	kappa opioid receptor	4986	4986	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human kappa_opioid_receptor gene -LRB- OPRK1 -RRB- polymorphism is associated with opiate_addiction .
17910740	0	OPRL1	64,69	nociceptin	43,53	OPRL1	nociceptin	4987	5368	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Association analysis of genes encoding the nociceptin receptor -LRB- OPRL1 -RRB- and its endogenous ligand -LRB- PNOC -RRB- with alcohol or illicit drug dependence .
24951719	0	OPRM1	45,50	DRD2	78,82	OPRM1	DRD2	4988	1813	Gene	Gene	Receptor|appos|START_ENTITY Receptor|appos|END_ENTITY	Genetic Variation of the Mu Opioid Receptor -LRB- OPRM1 -RRB- and Dopamine_D2_Receptor -LRB- DRD2 -RRB- is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar_Disorder .
21463018	0	OPRM1	20,25	Mu-opioid_receptor	0,18	OPRM1	Mu-opioid receptor	574141(Tax:9544)	574141(Tax:9544)	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Mu-opioid_receptor -LRB- OPRM1 -RRB- variation , oxytocin levels and maternal attachment in free-ranging rhesus_macaques Macaca_mulatta .
22551036	0	OPRM1	103,108	SLC6A3	135,141	OPRM1	SLC6A3	4988	6531	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm : influence of OPRM1 and dopamine_transporter -LRB- SLC6A3 -RRB- genes .
15558714	0	OPRM1	38,43	mu-opioid_receptor	13,31	OPRM1	mu-opioid receptor	4988	4988	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel exonic mu-opioid_receptor gene -LRB- OPRM1 -RRB- polymorphisms not associated with opioid_dependence .
11265402	0	OPRT	90,94	orotate_phosphoribosyl_transferase	45,79	OPRT	orotate phosphoribosyl transferase	7372	7372	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Expression and pathophysiologic features of orotate_phosphoribosyl_transferase activity -LRB- OPRT -RRB- in gastric_carcinoma -RSB- .
17607371	0	OPRT	49,53	orotate_phosphoribosyltransferase	14,47	OPRT	orotate phosphoribosyltransferase	7372	7372	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of orotate_phosphoribosyltransferase -LRB- OPRT -RRB- in hepatobiliary_and_pancreatic_carcinoma .
17293779	0	OPTN	25,29	optineurin	13,23	OPTN	optineurin	10133	10133	Gene	Gene	Variation|appos|START_ENTITY Variation|nmod|END_ENTITY	Variation in optineurin -LRB- OPTN -RRB- allele frequencies between and within populations .
10228158	0	ORC1	56,60	E2F	0,3	ORC1	E2F	35686(Tax:7227)	42550(Tax:7227)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila .
11379876	0	ORC5L	63,68	origin_recognition_complex_subunit_5	25,61	ORC5L	origin recognition complex subunit 5	5001	5001	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the origin_recognition_complex_subunit_5 -LRB- ORC5L -RRB- gene in adult patients with myeloid_leukemias exhibiting deletions of chromosome band 7q22 .
10697966	0	ORCTL2S	121,128	organic_cation_transporter-like_2-antisense	76,119	ORCTL2S	organic cation transporter-like 2-antisense	5003	5003	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel single nucleotide polymorphism -LRB- SNP -RRB- in the human organic_cation_transporter-like_2-antisense -LRB- ORCTL2S -RRB- gene .
24769897	0	ORCTL3	20,26	stearoyl-CoA_desaturase-1	35,60	ORCTL3	stearoyl-CoA desaturase-1	9390	6319	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	The anticancer gene ORCTL3 targets stearoyl-CoA_desaturase-1 for tumour-specific apoptosis .
11978759	0	ORF15	20,25	RPGR	10,14	ORF15	RPGR	6103	6103	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration .
18332319	0	ORF15	78,83	RPGR	91,95	ORF15	RPGR	6103	6103	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Discordant phenotypes in fraternal twins having an identical mutation in exon ORF15 of the RPGR gene .
18211098	0	ORF3	4,8	hemopexin	53,62	ORF3	hemopexin	9725255	3263	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The ORF3 protein of hepatitis_E_virus interacts with hemopexin by means of its 26 amino_acid_N-terminal hydrophobic domain II .
25694600	0	ORF33	72,77	USP7	91,95	ORF33	USP7	4961502(Tax:37296)	7874	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	A survey of the interactome of KSHV ORF45 revealed its binding to viral ORF33 and cellular USP7 resulting in stabilization of ORF33 that is required for production of progeny viruses .
24155375	0	ORF44	140,145	ORF49	23,28	ORF44	ORF49	1487718(Tax:10335)	1487656(Tax:10335)	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Varicella-zoster_virus ORF49 functions in the efficient production of progeny virus through its interaction with essential tegument protein ORF44 .
20980251	0	ORF45	136,141	IRF-7	79,84	ORF45	IRF-7	4961474(Tax:37296)	3665	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|nmod|END_ENTITY	Mechanisms of autoinhibition of IRF-7 and a probable model for inactivation of IRF-7 by Kaposi 's _ sarcoma-associated_herpesvirus protein ORF45 .
21994950	0	ORF45/RSK	121,130	eukaryotic_translation_initiation_factor_4B	19,62	ORF45/RSK	eukaryotic translation initiation factor 4B	4961474(Tax:37296)	1975	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4B -LRB- EIF4B -RRB- by open reading frame 45/p90 ribosomal_S6_kinase -LRB- ORF45/RSK -RRB- signaling axis facilitates protein translation during Kaposi_sarcoma-associated herpesvirus -LRB- KSHV -RRB- lytic replication .
21994950	0	ORF45/RSK	121,130	ribosomal_S6_kinase	100,119	ORF45/RSK	ribosomal S6 kinase	4961474(Tax:37296)	6196	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4B -LRB- EIF4B -RRB- by open reading frame 45/p90 ribosomal_S6_kinase -LRB- ORF45/RSK -RRB- signaling axis facilitates protein translation during Kaposi_sarcoma-associated herpesvirus -LRB- KSHV -RRB- lytic replication .
23269791	0	ORF47p	25,31	ORF9p	0,5	ORF47p	ORF9p	1487678(Tax:10335)	1487674(Tax:10335)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	ORF9p phosphorylation by ORF47p is crucial for the formation and egress of varicella-zoster_virus viral particles .
24155375	0	ORF49	23,28	ORF44	140,145	ORF49	ORF44	1487656(Tax:10335)	1487718(Tax:10335)	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Varicella-zoster_virus ORF49 functions in the efficient production of progeny virus through its interaction with essential tegument protein ORF44 .
11711586	0	ORF50	81,86	RTA	76,79	ORF50	RTA	4961526(Tax:37296)	4961526(Tax:37296)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of a cellular protein that interacts and synergizes with the RTA -LRB- ORF50 -RRB- protein of Kaposi 's _ sarcoma-associated_herpesvirus in transcriptional activation .
20159985	0	ORF57	60,65	Caspase-7	0,9	ORF57	Caspase-7	4961525(Tax:37296)	840	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Caspase-7 cleavage of Kaposi_sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression .
21106733	0	ORF57	40,45	RBM15	91,96	ORF57	RBM15	4961525(Tax:37296)	64783	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59 .
22761374	0	ORF57	92,97	REF/Aly	34,41	ORF57	REF/Aly	4961525(Tax:37296)	10189	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Binding of cellular export factor REF/Aly by Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- ORF57 protein is not required for efficient KSHV lytic replication .
25234929	0	ORF57	115,120	SRSF3	68,73	ORF57	SRSF3	4961525(Tax:37296)	6428	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi_sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing .
18786687	0	ORF59	78,83	RTA	40,43	ORF59	RTA	4961492(Tax:37296)	116535	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element .
23255809	0	ORF64	40,45	ZAP	0,3	ORF64	ZAP	1497174(Tax:33708)	56829	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	ZAP inhibits murine_gammaherpesvirus_68 ORF64 expression and is antagonized by RTA .
23269791	0	ORF9p	0,5	ORF47p	25,31	ORF9p	ORF47p	1487674(Tax:10335)	1487678(Tax:10335)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	ORF9p phosphorylation by ORF47p is crucial for the formation and egress of varicella-zoster_virus viral particles .
8980539	0	ORF_3	91,96	atp6	105,109	ORF 3	atp6	1466279(Tax:3708)	4237874(Tax:3708)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Alloplasmic male-sterile Brassica lines containing B. tournefortii mitochondria express an ORF_3 ' of the atp6 gene and a 32 kDa protein .
23238431	0	ORL1	103,107	MK-0911	22,29	ORL1	MK-0911	4987	1477012(Tax:190192)	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of -LSB- F -RSB- MK-0911 , a positron emission tomography -LRB- PET -RRB- tracer for opioid receptor-like 1 -LRB- ORL1 -RRB- , in rhesus_monkey and human .
15664818	0	ORL1	69,73	NOP	75,78	ORL1	NOP	4987	4987	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Synthesis and SAR studies of 3-phenoxypropyl_piperidine analogues as ORL1 -LRB- NOP -RRB- receptor agonists .
10651151	0	ORL1	92,96	Nociceptin	0,10	ORL1	Nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY rat|nmod|receptors inhibits|nmod|rat inhibits|nsubj|END_ENTITY	Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL1 receptors .
9042395	0	ORL1	60,64	Nociceptin	0,10	ORL1	Nociceptin	4987	5368	Gene	Gene	like1|appos|START_ENTITY agonist|nmod|like1 END_ENTITY|dep|agonist	Nociceptin : an endogenous agonist for central opioid like1 -LRB- ORL1 -RRB- receptors possesses systemic vasorelaxant properties .
9096263	0	ORL1	41,45	Nociceptin	0,10	ORL1	Nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY ligand|nmod|receptor endogenous|acl|ligand END_ENTITY|appos|endogenous	Nociceptin , an endogenous ligand for the ORL1 receptor , has novel hypotensive activity in the rat .
9213368	0	ORL1	41,45	Nociceptin	0,10	ORL1	Nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY ligand|nmod|receptor ligand|advcl|END_ENTITY	Nociceptin , an endogenous ligand for the ORL1 receptor , decreases_cardiac_output and total peripheral resistance in the rat .
9285926	0	ORL1	41,45	Nociceptin	0,10	ORL1	Nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY ligand|nmod|receptor endogenous|acl|ligand END_ENTITY|appos|endogenous	Nociceptin , an endogenous ligand for the ORL1 receptor , has vasodilator activity in the hindquarters vascular bed of the rat .
9384238	0	ORL1	35,39	Nociceptin	0,10	ORL1	Nociceptin	4987	5368	Gene	Gene	receptor|compound|START_ENTITY activation|nmod|receptor activation|compound|END_ENTITY	Nociceptin activation of the human ORL1 receptor expressed in Chinese_hamster ovary cells : functional homology with opioid receptors .
9879748	0	ORL1	46,50	Nociceptin	0,10	ORL1	Nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY ligand|nmod|receptor endogenous|acl|ligand END_ENTITY|appos|endogenous	Nociceptin , a novel endogenous ligand for the ORL1 receptor , dilates isolated resistance arteries from the rat .
10464356	0	ORL1	22,26	Opioid_receptor-like	0,20	ORL1	Opioid receptor-like	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor distribution in the rat central nervous system : comparison of ORL1 receptor mRNA expression with -LRB- 125 -RRB- I - -LSB- -LRB- 14 -RRB- Tyr -RSB- - orphanin_FQ binding .
16800795	0	ORL1	22,26	Opioid_receptor-like	0,20	ORL1	Opioid receptor-like	4987	4987	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor utilizes both G -LRB- oA -RRB- _ and_G -LRB- oB -RRB- for signal transduction .
11861322	0	ORL1	98,102	Orphanin_FQ	0,11	ORL1	Orphanin FQ	4987	5368	Gene	Gene	receptors|compound|START_ENTITY activation|nmod|receptors inhibits|nmod|activation inhibits|nsubj|END_ENTITY	Orphanin_FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors .
19190682	0	ORL1	65,69	Orphanin_FQ	26,37	ORL1	Orphanin FQ	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|nummod|START_ENTITY inhibits|nmod|receptor inhibits|nsubj|administration administration|nmod|END_ENTITY	Central administration of Orphanin_FQ inhibits GnRH secretion by ORL1 receptor in the median eminence of freely moving ovariectomized rats .
9051812	0	ORL1	47,51	Orphanin_FQ	0,11	ORL1	Orphanin FQ	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	agonist|nmod|START_ENTITY END_ENTITY|appos|agonist	Orphanin_FQ , agonist of orphan opioid receptor ORL1 , stimulates feeding in rats .
15276231	0	ORL1	99,103	low_density_lipoprotein_receptor	65,97	ORL1	low density lipoprotein receptor	4987	3949	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between polymorphisms in the lectin-like oxidised low_density_lipoprotein_receptor -LRB- ORL1 -RRB- gene on chromosome 12 and Alzheimer 's _ disease in a UK cohort .
10498840	0	ORL1	103,107	nociceptin	21,31	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptors|nummod|START_ENTITY agonist|nmod|receptors rectifier|nmod|agonist activation|nmod|rectifier Phe1psi|dep|activation Phe1psi|dep|END_ENTITY	-LSB- Phe1psi -LRB- CH2-NH -RRB- Gly2 -RSB- nociceptin - -LRB- 1 - 13 -RRB- - NH2 activation of an inward rectifier as a partial agonist of ORL1 receptors in rat periaqueductal gray .
10692489	0	ORL1	194,198	nociceptin	31,41	ORL1	nociceptin	4987	5368	Gene	Gene	domain|compound|START_ENTITY study|nmod|domain evidence|nmod|study inactivation|dep|evidence inactivation|nmod|receptor receptor|compound|END_ENTITY	Functional inactivation of the nociceptin receptor by alanine_substitution_of_glutamine_286 at the C terminus of transmembrane segment VI : evidence from a site-directed mutagenesis study of the ORL1 receptor transmembrane-binding domain .
10810242	0	ORL1	61,65	nociceptin	40,50	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Pharmacological characterization of the nociceptin receptor , ORL1 .
10814826	0	ORL1	67,71	nociceptin	47,57	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	An alternatively spliced transcript of the rat nociceptin receptor ORL1 gene encodes a truncated receptor .
10998522	0	ORL1	16,20	nociceptin	4,14	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The nociceptin -LRB- ORL1 -RRB- receptor : molecular cloning and functional architecture .
10998550	0	ORL1	77,81	nociceptin	56,66	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Species differences in the efficacy of compounds at the nociceptin receptor -LRB- ORL1 -RRB- .
11689089	0	ORL1	52,56	nociceptin	30,40	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|amod|START_ENTITY studies|dep|receptor studies|nmod|analogues analogues|compound|END_ENTITY	Structure-activity studies on nociceptin analogues : ORL1 receptor binding and biological activity of cyclic_disulfide-containing analogues of nociceptin peptides .
14550303	0	ORL1	66,70	nociceptin	54,64	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Identification of a hexapeptide binding region in the nociceptin -LRB- ORL1 -RRB- receptor by photo-affinity labelling with Ac-Arg-Bpa-Tyr-Arg-Trp-Arg-NH2 .
15707012	0	ORL1	58,62	nociceptin	80,90	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin -RSB- .
16321540	0	ORL1	0,4	nociceptin	40,50	ORL1	nociceptin	4987	5368	Gene	Gene	preferences|amod|START_ENTITY preferences|nmod|END_ENTITY	ORL1 and opioid receptor preferences of nociceptin and dynorphin_A analogues with Dmp substituted for N-terminal aromatic residues .
18068993	0	ORL1	44,48	nociceptin	49,59	ORL1	nociceptin	4987	5368	Gene	Gene	agonist|nmod|START_ENTITY modification|nmod|agonist END_ENTITY|nsubj|modification	Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist .
19577933	0	ORL1	115,119	nociceptin	101,111	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|nummod|START_ENTITY -RSB-|nmod|receptor -RSB-|dobj|END_ENTITY	Discriminatory synergistic effect of Trp-substitutions in superagonist -LSB- -LRB- Arg/Lys -RRB- -LRB- 14 -RRB- , -LRB- Arg/Lys -RRB- -LRB- 15 -RRB- -RSB- nociceptin on ORL1 receptor binding and activation .
19879767	0	ORL1	93,97	nociceptin	53,63	ORL1	nociceptin	4987	5368	Gene	Gene	activation|compound|START_ENTITY induction|nmod|activation -RSB-|nmod|induction -RSB-|dobj|END_ENTITY	Spare interactions of highly potent -LSB- Arg -LRB- 14 -RRB- , Lys -LRB- 15 -RRB- -RSB- nociceptin for cooperative induction of ORL1 receptor activation .
22061823	0	ORL1	94,98	nociceptin	99,109	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor .
25284251	0	ORL1	73,77	nociceptin	78,88	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor .
8732266	0	ORL1	16,20	nociceptin	62,72	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Increase by the ORL1 receptor -LRB- opioid receptor-like1 -RRB- ligand , nociceptin , of inwardly rectifying K conductance in dorsal raphe nucleus neurones .
8798582	0	ORL1	45,49	nociceptin	79,89	ORL1	nociceptin	4987	5368	Gene	Gene	START_ENTITY|nmod|modification modification|nmod|END_ENTITY	Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin , a naturally occurring nociceptive peptide .
8994054	0	ORL1	15,19	nociceptin	36,46	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY Actions|nmod|receptor ligand|nsubj|Actions ligand|dobj|END_ENTITY	Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro .
9086468	0	ORL1	76,80	nociceptin	38,48	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY END_ENTITY|appos|agonist	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by unilateral constriction_injury_to_the_sciatic_nerve in the rat .
9134994	0	ORL1	76,80	nociceptin	38,48	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY END_ENTITY|appos|agonist	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by carageenan injection into the rat paw .
9607332	0	ORL1	25,29	nociceptin	88,98	ORL1	nociceptin	4987	5368	Gene	Gene	domains|nmod|START_ENTITY involved|nsubjpass|domains involved|nmod|recognition recognition|nmod|A A|compound|END_ENTITY	Different domains of the ORL1 and kappa-opioid receptors are involved in recognition of nociceptin and dynorphin A .
9669489	0	ORL1	76,80	nociceptin	21,31	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|appos|START_ENTITY agonist|nmod|receptor agonist|nsubj|Phe1psi Phe1psi|dep|END_ENTITY	-LSB- Phe1psi -LRB- CH2-NH -RRB- Gly2 -RSB- nociceptin - -LRB- 1-13 -RRB- - NH2 is an agonist of the nociceptin -LRB- ORL1 -RRB- receptor .
9669489	0	ORL1	76,80	nociceptin	64,74	ORL1	nociceptin	4987	5368	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	-LSB- Phe1psi -LRB- CH2-NH -RRB- Gly2 -RSB- nociceptin - -LRB- 1-13 -RRB- - NH2 is an agonist of the nociceptin -LRB- ORL1 -RRB- receptor .
9726656	0	ORL1	55,59	nociceptin	14,24	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY ligand|nmod|receptor endogenous|acl|ligand effect|appos|endogenous effect|nmod|END_ENTITY	The effect of nociceptin , an endogenous ligand for the ORL1 receptor , on rat colonic contraction and transit .
9879729	0	ORL1	0,4	nociceptin	37,47	ORL1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor-mediated|nsubj|START_ENTITY receptor-mediated|nmod|END_ENTITY	ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery .
11324527	0	ORL1	46,50	opioid-receptor-like_receptor	15,44	ORL1	opioid-receptor-like receptor	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Expression of opioid-receptor-like_receptor -LRB- ORL1 -RRB- gene in rat brain -RSB- .
11413235	0	ORL1	39,43	opioid_receptor-like	17,37	ORL1	opioid receptor-like	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Dual coupling of opioid_receptor-like -LRB- ORL1 -RRB- receptors to adenylyl cyclase in the different layers of the rat main olfactory bulb .
12472900	0	ORL1	53,57	opioid_receptor-like	31,51	ORL1	opioid receptor-like	4987	4987	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Constitutive activation of the opioid_receptor-like -LRB- ORL1 -RRB- receptor by mutation of Asn133_to_tryptophan in the third transmembrane region .
14684324	0	ORL1	103,107	opioid_receptor-like	81,101	ORL1	opioid receptor-like	4987	4987	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The design and synthesis of a novel quinolizidine_template for potent opioid and opioid_receptor-like -LRB- ORL1 , NOP -RRB- receptor ligands .
18634857	0	ORL1	38,42	opioid_receptor-like	16,36	ORL1	opioid receptor-like	18389(Tax:10090)	18389(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The role of the opioid_receptor-like -LRB- ORL1 -RRB- receptor in motor stimulatory and rewarding actions of buprenorphine and morphine .
8733732	0	ORL1	40,44	opioid_receptor-like	18,38	ORL1	opioid receptor-like	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	Identification of opioid_receptor-like -LRB- ORL1 -RRB- peptide-stimulated -LSB- 35S -RSB- GTP gamma S binding in rat brain .
11591451	0	ORL1	56,60	opioid_receptor-like_1	32,54	ORL1	opioid receptor-like 1	18389(Tax:10090)	18389(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Autoradiographic mapping of the opioid_receptor-like_1 -LRB- ORL1 -RRB- receptor in the brains of mu - , delta - or kappa-opioid receptor knockout mice .
15802762	0	ORL1	38,42	opioid_receptor-like_1	14,36	ORL1	opioid receptor-like 1	18389(Tax:10090)	18389(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Expression of opioid_receptor-like_1 -LRB- ORL1 -RRB- _ mu opioid receptors in the spinal cord of morphine tolerant mice .
19398200	0	ORL1	64,68	opioid_receptor-like_1	40,62	ORL1	opioid receptor-like 1	4987	4987	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Optimization of benzimidazole series as opioid_receptor-like_1 -LRB- ORL1 -RRB- antagonists : SAR study directed toward improvement of selectivity over hERG activity .
19447610	0	ORL1	87,91	opioid_receptor-like_1	63,85	ORL1	opioid receptor-like 1	4987	4987	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of novel arylpyrazole series as potent and selective opioid_receptor-like_1 -LRB- ORL1 -RRB- antagonists .
19041249	0	ORL1	123,127	opioid_receptor_like-1	99,121	ORL1	opioid receptor like-1	4987	4987	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery and structure-activity relationships of 4-aminoquinazoline derivatives , a novel class of opioid_receptor_like-1 -LRB- ORL1 -RRB- antagonists .
10464356	0	ORL1	22,26	orphanin_FQ	151,162	ORL1	orphanin FQ	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|distribution distribution|dep|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor distribution in the rat central nervous system : comparison of ORL1 receptor mRNA expression with -LRB- 125 -RRB- I - -LSB- -LRB- 14 -RRB- Tyr -RSB- - orphanin_FQ binding .
10464356	0	ORL1	99,103	orphanin_FQ	151,162	ORL1	orphanin FQ	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY comparison|nmod|expression distribution|dep|comparison distribution|dep|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor distribution in the rat central nervous system : comparison of ORL1 receptor mRNA expression with -LRB- 125 -RRB- I - -LSB- -LRB- 14 -RRB- Tyr -RSB- - orphanin_FQ binding .
10758169	0	ORL1	59,63	orphanin_FQ	27,38	ORL1	orphanin FQ	4987	25516(Tax:10116)	Gene	Gene	agonist|dep|START_ENTITY agonist|nmod|END_ENTITY	A synthetic agonist at the orphanin_FQ / nociceptin receptor ORL1 : anxiolytic profile in the rat .
11719021	0	ORL1	56,60	orphanin_FQ	14,25	ORL1	orphanin FQ	4987	5368	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of orphanin_FQ and the opioid_receptor-like -LRB- ORL1 -RRB- receptor in the developing human and rat brain .
7789167	0	ORM1	46,50	alpha_1-acid_glycoprotein	14,39	ORM1	alpha 1-acid glycoprotein	396901(Tax:9823)	396901(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of alpha_1-acid_glycoprotein gene -LRB- ORM1 -RRB- to swine chromosome region 1q210 -- > q212 by fluorescence in situ hybridization .
26112603	0	ORMDL3	43,49	Cbl-b	20,25	ORMDL3	Cbl-b	94103	868	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	E3 ubiquitin ligase Cbl-b suppresses human ORMDL3 expression through STAT6 mediation .
22546552	0	ORMDL3	21,27	Ets-1	77,82	ORMDL3	Ets-1	94103	2113	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Mechanisms elevating ORMDL3 expression in recurrent wheeze patients : role of Ets-1 , p300 and CREB .
23461825	0	ORMDL3	76,82	Signal_transducer_and_activator_of_transcription_6	0,50	ORMDL3	Signal transducer and activator of transcription 6	94103	6778	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Signal_transducer_and_activator_of_transcription_6 directly regulates human ORMDL3 expression .
22906437	0	ORP10	0,5	apolipoprotein_B-100	77,97	ORP10	apolipoprotein B-100	114884	338	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	ORP10 , a cholesterol binding protein associated with microtubules , regulates apolipoprotein_B-100 secretion .
26700459	0	ORP150	67,73	Nrf2	15,19	ORP150	Nrf2	10525	4780	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Nrf2 in proteasome inhibition-mediated induction of ORP150 in thyroid_cancer cells .
11861666	0	ORP2	0,4	oxysterol_binding_protein	19,44	ORP2	oxysterol binding protein	9885	5007	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	ORP2 , a homolog of oxysterol_binding_protein , regulates cellular cholesterol metabolism .
12093806	0	OS-9	32,36	meprin_beta	71,82	OS-9	meprin beta	362891(Tax:10116)	25727(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	A selective interaction between OS-9 and the carboxyl-terminal tail of meprin_beta .
18952287	0	OS9	0,3	DC-STAMP	19,27	OS9	DC-STAMP	10956	81501	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation .
16970923	0	OSAD	41,45	TGF-beta1	50,59	OSAD	TGF-beta1	4958	7040	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of osteoadherin -LRB- OSAD -RRB- by TGF-beta1 and BMP-2 .
16970923	0	OSAD	41,45	osteoadherin	27,39	OSAD	osteoadherin	4958	4958	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of osteoadherin -LRB- OSAD -RRB- by TGF-beta1 and BMP-2 .
9806908	0	OSBP	49,53	oxysterol_binding_protein	22,47	OSBP	oxysterol binding protein	100760367	100760367	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Cholesterol regulates oxysterol_binding_protein -LRB- OSBP -RRB- phosphorylation and Golgi localization in Chinese_hamster_ovary cells : correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol .
21669198	0	OSBP-related_protein_7	0,22	GATE-16	38,45	OSBP-related protein 7	GATE-16	114881	11345	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	OSBP-related_protein_7 interacts with GATE-16 and negatively regulates GS28 protein stability .
17991739	0	OSBP-related_protein_8	0,22	ABCA1	41,46	OSBP-related protein 8	ABCA1	114882	19	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	OSBP-related_protein_8 -LRB- ORP8 -RRB- suppresses ABCA1 expression and cholesterol efflux from macrophages .
21698267	0	OSBP-related_protein_8	0,22	Nup62	112,117	OSBP-related protein 8	Nup62	237542(Tax:10090)	18226(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	OSBP-related_protein_8 -LRB- ORP8 -RRB- regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62 .
24424245	0	OSBP-related_protein_8	0,22	sperm_associated_antigen_5	58,84	OSBP-related protein 8	sperm associated antigen 5	114882	10615	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	OSBP-related_protein_8 -LRB- ORP8 -RRB- interacts with Homo_sapiens sperm_associated_antigen_5 -LRB- SPAG5 -RRB- and mediates oxysterol interference of HepG2 cell cycle .
11278871	0	OSBP2	81,86	oxysterol-binding_protein	54,79	OSBP2	oxysterol-binding protein	23762	23762	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular and biochemical characterization of a novel oxysterol-binding_protein -LRB- OSBP2 -RRB- highly expressed in retina .
9325176	0	OSF-1	44,49	osteoblast-specific_factor-1	14,42	OSF-1	osteoblast-specific factor-1	19242(Tax:10090)	19242(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Regulation of osteoblast-specific_factor-1 -LRB- OSF-1 -RRB- mRNA expression by dual promoters as revealed by RT-PCR .
7663166	0	OSF-2	72,77	osteoblast-specific_factor_2	42,70	OSF-2	osteoblast-specific factor 2	50706(Tax:10090)	50706(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and characterization of murine osteoblast-specific_factor_2 -LRB- OSF-2 -RRB- in a baculovirus expression system .
23797667	0	OSM	38,41	oncostatin_M	24,36	OSM	oncostatin M	18413(Tax:10090)	18413(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Pulmonary expression of oncostatin_M -LRB- OSM -RRB- promotes inducible BALT formation independently of IL-6 , despite a role for IL-6 in OSM-driven pulmonary_inflammation .
8422753	0	OSM	45,48	oncostatin_M	26,38	OSM	oncostatin M	5008	5008	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization of the human oncostatin_M gene -LRB- OSM -RRB- to chromosome 22q12 , distal to the Ewing 's _ sarcoma breakpoint .
19177573	0	OSR1	42,46	STE20	36,41	SPAK	STE20	27347	8428	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Crystal structure of domain-swapped STE20 OSR1 kinase domain .
25362046	0	OSR1	109,113	WNK1	30,34	OSR1	WNK1	9943	65125	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Actions Actions|nmod|END_ENTITY	Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK .
23530066	0	OST	92,95	STT3B	71,76	OST	STT3B	1650	201595	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST .
12397596	0	OST-PTP	61,68	tyrosine_phosphatase	34,54	OST-PTP	tyrosine phosphatase	13924(Tax:10090)	13924(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of the tyrosine_phosphatase gene , OST-PTP , during osteoblast differentiation .
21085673	0	OST1	37,41	ABF3	87,91	OST1	ABF3	829541(Tax:3702)	829547(Tax:3702)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The Arabidopsis ABA-activated kinase OST1 phosphorylates the bZIP transcription factor ABF3 and creates a 14-3-3 binding site involved in its turnover .
25669882	0	OST1	0,4	ICE1	54,58	OST1	ICE1	829541(Tax:3702)	822287(Tax:3702)	Gene	Gene	kinase|compound|START_ENTITY modulates|nsubj|kinase modulates|advcl|enhancing enhancing|dobj|stability stability|compound|END_ENTITY	OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis .
25680856	0	OST1	0,4	ICE1	20,24	OST1	ICE1	6184	23379	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	OST1 phosphorylates ICE1 to enhance plant cold tolerance .
23606741	0	OST4	0,4	oligosaccharyltransferase	35,60	OST4	oligosaccharyltransferase	100128731	1650	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation .
22940129	0	OSTF1	61,66	osmotic_stress_transcription_factor_1	22,59	OSTF1	osmotic stress transcription factor 1	100707559	100707559	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	miR-429 regulation of osmotic_stress_transcription_factor_1 -LRB- OSTF1 -RRB- in tilapia during osmotic stress .
12402347	0	OTC	85,88	ornithine_transcarbamylase	57,83	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	H intragenic polymorphisms and haplotype analysis in the ornithine_transcarbamylase -LRB- OTC -RRB- gene and their relevance for tracking the inheritance of OTC_deficiency .
16786505	0	OTC	69,72	ornithine_transcarbamylase	41,67	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations and polymorphisms in the human ornithine_transcarbamylase -LRB- OTC -RRB- gene .
17041896	0	OTC	75,78	ornithine_transcarbamylase	47,73	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of novel mutations in the human ornithine_transcarbamylase -LRB- OTC -RRB- gene of Korean patients with OTC_deficiency and transient expression of the mutant proteins in vitro .
17044854	0	OTC	96,99	ornithine_transcarbamylase	63,89	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational spectrum and linkage disequilibrium patterns at the ornithine_transcarbamylase gene -LRB- OTC -RRB- .
18204299	0	OTC	53,56	ornithine_transcarbamylase	25,51	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the ornithine_transcarbamylase -LRB- OTC -RRB- gene in five Japanese OTC_deficiency patients revealed two known and three novel mutations including a deep intronic mutation .
19475717	0	OTC	87,90	ornithine_transcarbamylase	59,85	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular mechanisms underlying large genomic deletions in ornithine_transcarbamylase -LRB- OTC -RRB- gene .
7999674	0	OTC	136,139	ornithine_transcarbamylase	108,134	OTC	ornithine transcarbamylase	25611(Tax:10116)	25611(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Normalization of hair growth in sparse fur-abnormal skin and hair -LRB- SPF-ASH -RRB- mice by introduction of the rat ornithine_transcarbamylase -LRB- OTC -RRB- gene .
8019156	0	OTC	55,58	ornithine_transcarbamylase	27,53	OTC	ornithine transcarbamylase	25611(Tax:10116)	25611(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Effects of zinc on hepatic ornithine_transcarbamylase -LRB- OTC -RRB- activity .
8830175	0	OTC	67,70	ornithine_transcarbamylase	39,65	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of new mutations in the ornithine_transcarbamylase -LRB- OTC -RRB- gene in Korean families .
9286441	0	OTC	32,35	ornithine_transcarbamylase	4,30	OTC	ornithine transcarbamylase	5009	5009	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The ornithine_transcarbamylase -LRB- OTC -RRB- gene : mutations in 50 Japanese families with OTC_deficiency .
14635104	0	OTOF	74,78	otoferlin	58,67	OTOF	otoferlin	9381	9381	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Auditory_neuropathy in patients carrying mutations in the otoferlin gene -LRB- OTOF -RRB- .
19250381	0	OTOF	63,67	otoferlin	47,56	OTOF	otoferlin	9381	9381	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identities and frequencies of mutations of the otoferlin gene -LRB- OTOF -RRB- causing DFNB9_deafness in Pakistan .
21771110	0	OTR	57,60	IFNAR-1	26,33	OTR	IFNAR-1	443138(Tax:9940)	443126(Tax:9940)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Endometrial expression of IFNAR-1 and oxytocin_receptor -LRB- OTR -RRB- is not improved by prostaglandin analogues when compared to progestagens in ewes .
24071738	0	OTUB1	0,5	TGFb	15,19	OTUB1	TGFb	55611	7040	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	OTUB1 enhances TGFb signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3 .
25499082	0	OTUD5	15,20	PDCD5	59,64	OTUD5	PDCD5	55593	9141	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress .
12559959	0	OTX2	0,4	DOPAchrome_tautomerase	29,51	OTX2	DOPAchrome tautomerase	5015	1638	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	OTX2 regulates expression of DOPAchrome_tautomerase in human retinal_pigment_epithelium .
25231759	0	OTX2	16,20	Dkk1	31,35	OTX2	Dkk1	18424(Tax:10090)	13380(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Head formation : OTX2 regulates Dkk1 and Lhx1 activity in the anterior_mesendoderm .
10623575	0	OTX2	0,4	LIM1	29,33	OTX2	LIM1	18424(Tax:10090)	16869(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	OTX2 directly interacts with LIM1 and HNF-3beta .
10216227	0	OTX2	30,34	NCAM	45,49	OTX2	NCAM	18424(Tax:10090)	17967(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The mouse homeodomain protein OTX2 regulates NCAM promoter activity .
17872382	0	OTX5	0,4	REV-ERB_alpha	50,63	OTX5	REV-ERB alpha	353179(Tax:7955)	494487(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	OTX5 regulates pineal expression of the zebrafish REV-ERB_alpha through a new DNA binding site .
21487939	0	OVCA1	0,5	cyclin_D1	82,91	OVCA1	cyclin D1	1801	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	OVCA1 inhibits the proliferation of epithelial ovarian_cancer cells by decreasing cyclin_D1 and increasing p16 .
20118424	0	OVGP1	47,52	oviductal_glycoprotein_1	21,45	OVGP1	oviductal glycoprotein 1	1502145(Tax:11027)	100008811(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation of the oviductal_glycoprotein_1 -LRB- OVGP1 -RRB- gene associated with embryo survival and development in the rabbit .
20803175	0	OX1R	54,58	orexin-1_receptor	35,52	OX1R	orexin-1 receptor	230777(Tax:10090)	230777(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of the orexin-1_receptor -LRB- OX1R -RRB- after traumatic_brain_injury in mice .
26653571	0	OX2-R	144,149	Orexin_Type_2	129,142	OX2-R	Orexin Type 2	3062	3062	Gene	Gene	Receptors|appos|START_ENTITY Receptors|compound|END_ENTITY	Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia : Involvement of Orexin_Type_2 -LRB- OX2-R -RRB- Receptors .
11567634	0	OX40	0,4	Bcl-xL	14,20	OX40	Bcl-xL	7293	598	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells .
20400327	0	OX40	0,4	CCL20	13,18	OX40	CCL20	22163(Tax:10090)	20297(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	OX40 induces CCL20 expression in the context of antigen stimulation : an expanding role of co-stimulatory molecules in chemotaxis .
11739485	0	OX40	86,90	CD134	92,97	OX40	CD134	22163(Tax:10090)	22163(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Multiple levels of activation of murine CD8 -LRB- + -RRB- intraepithelial lymphocytes defined by OX40 -LRB- CD134 -RRB- expression : effects on cell-mediated cytotoxicity , IFN-gamma , and IL-10 regulation .
12786817	0	OX40	46,50	CD134	39,44	OX40	CD134	7293	7293	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of T-cell activation marker CD134 -LRB- OX40 -RRB- in lymphomatoid_papulosis .
15327522	0	OX40	53,57	CD134	45,50	OX40	CD134	7293	7293	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Kinetic of regulatory CD25high and activated CD134 + -LRB- OX40 -RRB- T lymphocytes during acute and chronic_graft-versus-host_disease after allogeneic bone marrow transplantation .
16367941	0	OX40	14,18	CD134	20,25	OX40	CD134	7293	7293	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of OX40 -LRB- CD134 -RRB- on CD4 + T-cells from patients with myasthenia_gravis .
18374895	0	OX40	0,4	CD134	6,11	OX40	CD134	7293	7293	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	OX40 -LRB- CD134 -RRB- expression in sentinel lymph nodes correlates with prognostic features of primary melanomas .
20795540	0	OX40	12,16	CD134	18,23	OX40	CD134	7293	7293	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of OX40 -LRB- CD134 -RRB- in T-cell memory generation .
17641007	0	OX40	14,18	CD25	94,98	OX40	CD25	7293	3559	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
24797972	0	OX40	19,23	CD25	69,73	OX40	CD25	7293	3559	Gene	Gene	expression|nmod|START_ENTITY molecules|nsubj|expression molecules|nmod|cells cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
10359115	0	OX40	62,66	CD4	0,3	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|nmod|START_ENTITY leads|nsubj|ligation control|ccomp|leads control|nsubj|traffic traffic|nummod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	OX40	62,66	CD4	155,158	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|nmod|START_ENTITY leads|nsubj|ligation leads|nmod|accumulation accumulation|nmod|cells cells|compound|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	OX40	62,66	CD4	70,73	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10975814	0	OX40	4,8	CD4	62,65	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY determines|nsubj|receptor determines|dobj|development development|nmod|memory memory|compound|END_ENTITY	The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion .
11414737	0	OX40	0,4	CD4	59,62	OX40	CD4	7293	920	Gene	Gene	ligation|compound|START_ENTITY enhances|nsubj|ligation enhances|dobj|turnover turnover|nmod|cells cells|compound|END_ENTITY	OX40 ligation enhances cell cycle turnover of Ag-activated CD4 T cells in vivo .
11739496	0	OX40	14,18	CD4	45,48	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	Engagement|nmod|START_ENTITY enhances|nsubj|Engagement enhances|dobj|T T|compound|END_ENTITY	Engagement of OX40 enhances antigen-specific CD4 -LRB- + -RRB- T cell mobilization/memory development and humoral immunity : comparison of alphaOX-40 with alphaCTLA-4 .
12460238	0	OX40	128,132	CD4	134,137	OX40	CD4	7293	920	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Myasthenia_gravis after allogeneic bone marrow transplantation treated with mycophenolate_mofetil monitored by peripheral blood OX40 + CD4 + T cells .
12753741	0	OX40	68,72	CD4	0,3	OX40	CD4	7293	920	Gene	Gene	primed|nmod|START_ENTITY primed|nsubj|CD3 CD3|compound|END_ENTITY	CD4 -LRB- + -RRB- CD3 -LRB- - -RRB- accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells .
12753741	0	OX40	68,72	CD4	48,51	OX40	CD4	7293	920	Gene	Gene	primed|nmod|START_ENTITY primed|dobj|cells cells|compound|END_ENTITY	CD4 -LRB- + -RRB- CD3 -LRB- - -RRB- accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells .
15591118	0	OX40	112,116	CD4	30,33	OX40	CD4	7293	920	Gene	Gene	role|nmod|START_ENTITY activity|dep|role blocks|dobj|activity blocks|dep|Triggering Triggering|nmod|OX40 OX40|nmod|CD25 CD25|compound|END_ENTITY	Triggering of OX40 -LRB- CD134 -RRB- on CD4 -LRB- + -RRB- CD25 + T cells blocks their inhibitory activity : a novel regulatory role for OX40 and its comparison with GITR .
15591118	0	OX40	14,18	CD4	30,33	OX40	CD4	7293	920	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Triggering of OX40 -LRB- CD134 -RRB- on CD4 -LRB- + -RRB- CD25 + T cells blocks their inhibitory activity : a novel regulatory role for OX40 and its comparison with GITR .
15778343	0	OX40	18,22	CD4	92,95	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	deficient|nmod|START_ENTITY signals|nsubj|deficient signals|dobj|responses responses|nmod|memory memory|compound|END_ENTITY	Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory .
16176850	0	OX40	35,39	CD4	14,17	OX40	CD4	7293	920	Gene	Gene	T|nmod|START_ENTITY T|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CD4 T cell memory by OX40 -LRB- CD134 -RRB- .
16367941	0	OX40	14,18	CD4	30,33	OX40	CD4	7293	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|T-cells T-cells|compound|END_ENTITY	Expression of OX40 -LRB- CD134 -RRB- on CD4 + T-cells from patients with myasthenia_gravis .
16456009	0	OX40	0,4	CD4	17,20	OX40	CD4	7293	920	Gene	Gene	ligation|nummod|START_ENTITY ligation|nmod|cells cells|compound|END_ENTITY	OX40 ligation of CD4 + T cells enhances virus-specific CD8 + T cell memory responses independently of IL-2 and CD4 + T regulatory cell inhibition .
16541471	0	OX40	0,4	CD4	50,53	OX40	CD4	7293	920	Gene	Gene	engagement|nsubj|START_ENTITY engagement|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	OX40 -LRB- CD134 -RRB- engagement drives differentiation of CD4 + T cells to effector cells .
17429847	0	OX40	79,83	CD4	20,23	OX40	CD4	7293	920	Gene	Gene	signals|nummod|START_ENTITY enhanced|nmod|signals enhanced|nsubjpass|Cooperation Cooperation|nmod|cells cells|compound|END_ENTITY	Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals .
17584577	0	OX40	46,50	CD4	77,80	OX40	CD4	7293	920	Gene	Gene	expression|nmod|START_ENTITY Requirements|nmod|expression ligand|nsubj|Requirements ligand|nmod|+ +|compound|END_ENTITY	Requirements for the functional expression of OX40 ligand on human activated CD4 + and CD8 + T cells .
17641007	0	OX40	14,18	CD4	77,80	OX40	CD4	7293	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|conversion conversion|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17911586	0	OX40	30,34	CD4	88,91	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	requirements|nmod|START_ENTITY signals|nsubj|requirements signals|nmod|generation generation|nmod|cells cells|compound|END_ENTITY	Differential requirements for OX40 signals on generation of effector and central memory CD4 + T cells .
18275893	0	OX40	46,50	CD4	41,44	OX40	CD4	7293	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Growth and differentiation advantages of CD4 + OX40 + T cells from allogeneic hematopoietic stem cell transplantation recipients .
19635903	0	OX40	126,130	CD4	38,41	OX40	CD4	7293	920	Gene	Gene	CD25|appos|START_ENTITY coexpression|nmod|CD25 revealed|nmod|coexpression revealed|nsubj|levels levels|nmod|cells cells|compound|END_ENTITY	High levels of human antigen-specific CD4 + T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 -LRB- OX40 -RRB- .
19786532	0	OX40	75,79	CD4	23,26	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY requires|dobj|signals requires|nsubj|survival survival|nmod|cells cells|compound|END_ENTITY	The survival of memory CD4 + T cells within the gut lamina propria requires OX40 and CD30 signals .
20019337	0	OX40	7,11	CD4	26,29	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|amod|engagement engagement|nmod|cells cells|nummod|END_ENTITY	Serial OX40 engagement on CD4 + T cells and natural killer T cells causes allergic_airway_inflammation .
22017436	0	OX40	0,4	CD4	134,137	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY signals|dep|role role|nmod|cells cells|acl|maintaining maintaining|dobj|memory memory|compound|END_ENTITY	OX40 and CD30 signals in CD4 -LRB- + -RRB- T-cell effector and memory function : a distinct role for lymphoid tissue inducer cells in maintaining CD4 -LRB- + -RRB- T-cell memory but not effector function .
22017436	0	OX40	0,4	CD4	25,28	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY signals|nmod|effector effector|amod|END_ENTITY	OX40 and CD30 signals in CD4 -LRB- + -RRB- T-cell effector and memory function : a distinct role for lymphoid tissue inducer cells in maintaining CD4 -LRB- + -RRB- T-cell memory but not effector function .
22754764	0	OX40	0,4	CD4	112,115	OX40	CD4	7293	920	Gene	Gene	costimulation|nummod|START_ENTITY abrogates|nsubj|costimulation abrogates|dobj|CD28 CD28|acl|induced induced|nmod|T T|compound|END_ENTITY	OX40 costimulation by a chimeric_antigen_receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4 -LRB- + -RRB- T cells .
24468748	0	OX40	101,105	CD4	13,16	OX40	CD4	7293	920	Gene	Gene	agonist|compound|START_ENTITY immunotherapy|nmod|agonist melanomas|xcomp|immunotherapy melanomas|nsubj|sensitizes sensitizes|compound|END_ENTITY	Intratumoral CD4 + T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist .
24771127	0	OX40	0,4	CD4	23,26	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|ccomp|effector effector|dobj|expansion expansion|compound|END_ENTITY	OX40 controls effector CD4 + T-cell expansion , not follicular T helper cell generation in acute Listeria_infection .
24797972	0	OX40	19,23	CD4	63,66	OX40	CD4	7293	920	Gene	Gene	expression|nmod|START_ENTITY molecules|nsubj|expression molecules|nmod|cells cells|amod|END_ENTITY	High expression of OX40 -LRB- CD134 -RRB- and 4-1BB -LRB- CD137 -RRB- molecules on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- cells in children with type_1_diabetes .
25103720	0	OX40	0,4	CD4	89,92	OX40	CD4	22163(Tax:10090)	12504(Tax:10090)	Gene	Gene	play|nsubj|START_ENTITY play|ccomp|T T|nsubj|roles roles|nmod|proliferation proliferation|nmod|END_ENTITY	OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4 -LRB- + -RRB- T cells .
17641007	0	OX40	14,18	Foxp3	99,104	OX40	Foxp3	7293	50943	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
10359115	0	OX40	62,66	OX40-ligand	85,96	OX40	OX40-ligand	22163(Tax:10090)	22164(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
22017437	0	OX40	0,4	OX40L	5,10	OX40	OX40L	7293	7292	Gene	Gene	START_ENTITY|dep|axis axis|nummod|END_ENTITY	OX40 : OX40L axis : emerging targets for improving poxvirus-based CD8 -LRB- + -RRB- T-cell vaccines against respiratory viruses .
8613423	0	OX40	13,17	Tax	93,96	OX40	Tax	7293	1491938(Tax:11908)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of OX40 , a receptor of gp34 , on T cells by trans-acting transcriptional activator , Tax , of human_T-cell_leukemia_virus_type_I .
10477563	0	OX40	37,41	gp34	27,31	OX40	gp34	7293	7292	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|appos|ligand	Intracellular signaling of gp34 , the OX40 ligand : induction of c-jun and c-fos mRNA expression through gp34 upon binding of its receptor , OX40 .
11071109	0	OX40	14,18	gp34	36,40	OX40	gp34	7293	7292	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression of OX40 and OX40 ligand -LRB- gp34 -RRB- in the normal and myasthenic thymus .
11346458	0	OX40	20,24	gp34	14,18	OX40	gp34	7293	7292	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|appos|ligand	Expression of gp34 -LRB- OX40 ligand -RRB- and OX40 on human T cell clones .
23896866	0	OX40	179,183	tumor_necrosis_factor_receptor-associated_factor_6	114,164	OX40	tumor necrosis factor receptor-associated factor 6	7293	7189	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Enhanced activity of Akt in Teff cells from children with lupus_nephritis is associated with reduced induction of tumor_necrosis_factor_receptor-associated_factor_6 and increased OX40 expression .
10359115	0	OX40-ligand	85,96	CD4	0,3	OX40-ligand	CD4	22164(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY OX40|nmod|cells ligation|nmod|OX40 leads|nsubj|ligation control|ccomp|leads control|nsubj|traffic traffic|nummod|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	OX40-ligand	85,96	CD4	155,158	OX40-ligand	CD4	22164(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY OX40|nmod|cells ligation|nmod|OX40 leads|nsubj|ligation leads|nmod|accumulation accumulation|nmod|cells cells|compound|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	OX40-ligand	85,96	CD4	70,73	OX40-ligand	CD4	22164(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
10359115	0	OX40-ligand	85,96	OX40	62,66	OX40-ligand	OX40	22164(Tax:10090)	22163(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	CD4 T cell traffic control : in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles .
11745696	0	OX40L	101,106	CD27L	94,99	OX40L	CD27L	22164(Tax:10090)	21948(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumour necrosis factor -LRB- TNF -RRB- ligand superfamily co-stimulatory molecules CD30L , CD27L , OX40L , and 4-1BBL in murine hearts with acute_myocarditis caused by Coxsackievirus B3 .
12031769	0	OX40L	93,98	CD27L	79,84	OX40L	CD27L	7292	970	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L , CD30L , OX40L and 4-1BBL in the heart of patients with acute_myocarditis and dilated_cardiomyopathy .
11745696	0	OX40L	101,106	CD30L	87,92	OX40L	CD30L	22164(Tax:10090)	21949(Tax:10090)	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumour necrosis factor -LRB- TNF -RRB- ligand superfamily co-stimulatory molecules CD30L , CD27L , OX40L , and 4-1BBL in murine hearts with acute_myocarditis caused by Coxsackievirus B3 .
12031769	0	OX40L	93,98	CD30L	86,91	OX40L	CD30L	7292	944	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression of tumor necrosis factor ligand superfamily costimulatory molecules CD27L , CD30L , OX40L and 4-1BBL in the heart of patients with acute_myocarditis and dilated_cardiomyopathy .
19029446	0	OX40L	89,94	CD70	96,100	OX40L	CD70	7292	970	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Prostaglandin_E -LRB- 2 -RRB- enhances T-cell proliferation by inducing the costimulatory molecules OX40L , CD70 , and 4-1BBL on dendritic cells .
22017437	0	OX40L	5,10	OX40	0,4	OX40L	OX40	7292	7293	Gene	Gene	axis|nummod|START_ENTITY END_ENTITY|dep|axis	OX40 : OX40L axis : emerging targets for improving poxvirus-based CD8 -LRB- + -RRB- T-cell vaccines against respiratory viruses .
19778912	0	OX40L	23,28	TNFSF4	15,21	OX40L	TNFSF4	7292	7292	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of TNFSF4 -LRB- OX40L -RRB- polymorphisms with susceptibility to systemic_sclerosis .
1486803	0	OXT	43,46	oxytocin-neurophysin_I	19,41	OXT	oxytocin-neurophysin I	5020	5020	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The human gene for oxytocin-neurophysin_I -LRB- OXT -RRB- is physically mapped to chromosome 20p13 by in situ hybridization .
18655900	0	OXTR	102,106	AVPR1a	67,73	OXTR	AVPR1a	5021	552	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Molecular genetic studies of the arginine_vasopressin 1a receptor -LRB- AVPR1a -RRB- and the oxytocin_receptor -LRB- OXTR -RRB- in human behaviour : from autism to altruism with some notes in between .
26299644	0	OXTR	95,99	Avpr1a	55,61	OXTR	Avpr1a	738742(Tax:9598)	452038(Tax:9598)	Gene	Gene	variation|appos|START_ENTITY variation|amod|vasopressin vasopressin|dep|END_ENTITY	Chimpanzee sociability is associated with vasopressin -LRB- Avpr1a -RRB- but not oxytocin_receptor gene -LRB- OXTR -RRB- variation .
26061800	0	OXTR	140,144	BDNF	111,115	OXTR	BDNF	5021	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Childhood maternal care is associated with DNA methylation of the genes for brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and oxytocin_receptor -LRB- OXTR -RRB- in peripheral blood cells in adult men and women .
20303388	0	OXTR	19,23	Oxytocin	0,8	OXTR	Oxytocin	5021	5020	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Oxytocin receptor -LRB- OXTR -RRB- does not play a major role in the aetiology of autism : genetic and molecular studies .
26121678	0	OXTR	39,43	Oxytocin_Receptor	15,32	OXTR	Oxytocin Receptor	5021	5021	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of Oxytocin_Receptor Gene -LRB- OXTR -RRB- rs53576 Polymorphism with Sociality : A Meta-Analysis .
21896752	0	OXTR	24,28	Oxytocin_receptor	0,17	OXTR	Oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Oxytocin_receptor gene -LRB- OXTR -RRB- is related to psychological resources .
20585395	0	OXTR	42,46	oxytocin	23,31	OXTR	oxytocin	5021	5020	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No association between oxytocin receptor -LRB- OXTR -RRB- gene polymorphisms and experimentally elicited social preferences .
22336563	0	OXTR	80,84	oxytocin	46,54	OXTR	oxytocin	5021	5020	Gene	Gene	genes|compound|START_ENTITY associated|nmod|genes associated|nmod|END_ENTITY	Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes .
19376182	0	OXTR	49,53	oxytocin_receptor	25,42	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations between the oxytocin_receptor gene -LRB- OXTR -RRB- and affect , loneliness and intelligence in normal subjects .
20094064	0	OXTR	38,42	oxytocin_receptor	19,36	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the oxytocin_receptor -LRB- OXTR -RRB- gene polymorphisms with autism_spectrum_disorder -LRB- ASD -RRB- in the Japanese population .
20347913	0	OXTR	58,62	oxytocin_receptor	39,56	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence that genetic variation in the oxytocin_receptor -LRB- OXTR -RRB- gene influences social cognition in ADHD .
21484202	0	OXTR	34,38	oxytocin_receptor	15,32	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of oxytocin_receptor -LRB- OXTR -RRB- gene variants with multiple phenotype domains of autism_spectrum_disorder .
22084107	0	OXTR	45,49	oxytocin_receptor	26,43	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Thin-slicing study of the oxytocin_receptor -LRB- OXTR -RRB- gene and the evaluation and expression of the prosocial disposition .
22123970	0	OXTR	31,35	oxytocin_receptor	7,24	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Common oxytocin_receptor gene -LRB- OXTR -RRB- polymorphism and social support interact to reduce stress in humans .
22357335	0	OXTR	61,65	oxytocin_receptor	24,41	OXTR	oxytocin receptor	5021	5021	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	The association between oxytocin_receptor gene polymorphism -LRB- OXTR -RRB- and trait empathy .
22809402	0	OXTR	49,53	oxytocin_receptor	25,42	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations between the oxytocin_receptor gene -LRB- OXTR -RRB- and `` mind-reading '' in humans -- an exploratory study .
23470776	0	OXTR	46,50	oxytocin_receptor	22,39	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Environmental stress , oxytocin_receptor gene -LRB- OXTR -RRB- polymorphism , and mental health following collective stress .
23547247	0	OXTR	37,41	oxytocin_receptor	13,30	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variation in oxytocin_receptor gene -LRB- OXTR -RRB- polymorphisms is associated with emotional and behavioral reactions to betrayal .
23562248	0	OXTR	52,56	oxytocin_receptor	28,45	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The association between the oxytocin_receptor gene -LRB- OXTR -RRB- and hypnotizability .
24223720	0	OXTR	28,32	oxytocin_receptor	4,21	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The oxytocin_receptor gene -LRB- OXTR -RRB- in relation to state levels of loneliness in adolescence : evidence for micro-level gene-environment interactions .
24348360	0	OXTR	64,68	oxytocin_receptor	40,57	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Navigating the complex path between the oxytocin_receptor gene -LRB- OXTR -RRB- and cooperation : an endophenotype approach .
24367110	0	OXTR	51,55	oxytocin_receptor	27,44	OXTR	oxytocin receptor	5021	5021	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Common polymorphism in the oxytocin_receptor gene -LRB- OXTR -RRB- is associated with human social recognition skills .
24485285	0	OXTR	43,47	oxytocin_receptor	24,41	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the oxytocin_receptor -LRB- OXTR -RRB- gene and mesolimbic responses to rewards .
24916666	0	OXTR	43,47	oxytocin_receptor	24,41	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between the oxytocin_receptor -LRB- OXTR -RRB- gene and children 's social cognition at 18 months .
25092245	0	OXTR	28,32	oxytocin_receptor	4,21	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The oxytocin_receptor gene -LRB- OXTR -RRB- is associated with autism_spectrum_disorder : a meta-analysis .
25264479	0	OXTR	44,48	oxytocin_receptor	25,42	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variation in the oxytocin_receptor -LRB- OXTR -RRB- gene is associated with Asperger_Syndrome .
26178189	0	OXTR	33,37	oxytocin_receptor	9,26	OXTR	oxytocin receptor	5021	5021	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	A common oxytocin_receptor gene -LRB- OXTR -RRB- polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans .
26250573	0	OXTR	94,98	oxytocin_receptor	70,87	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Rigorous tests of gene-environment interactions in a lab study of the oxytocin_receptor gene -LRB- OXTR -RRB- , alcohol exposure , and aggression .
26250573	0	OXTR	94,98	oxytocin_receptor	70,87	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Rigorous tests of gene-environment interactions in a lab study of the oxytocin_receptor gene -LRB- OXTR -RRB- , alcohol exposure , and aggression .
26377392	0	OXTR	55,59	oxytocin_receptor	36,53	OXTR	oxytocin receptor	5021	5021	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Myometrial contractility influences oxytocin_receptor -LRB- OXTR -RRB- expression in term trophoblast cells obtained from the maternal surface of the human placenta .
27081536	0	OXTR	48,52	oxytocin_receptor	29,46	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel rare variations of the oxytocin_receptor -LRB- OXTR -RRB- gene in autism_spectrum_disorder individuals .
27082423	0	OXTR	57,61	oxytocin_receptor	38,55	OXTR	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Erratum : Novel rare variations of the oxytocin_receptor -LRB- OXTR -RRB- gene in autism_spectrum_disorder individuals .
22305621	0	Oas1b	113,118	STAT2	91,96	Oas1b	STAT2	23961(Tax:10090)	20847(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation .
17719021	0	Oat3	41,45	organic_anion_transporter_3	12,39	Oat3	organic anion transporter 3	83500(Tax:10116)	83500(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of rat organic_anion_transporter_3 -LRB- Oat3 -RRB- in the renal basolateral transport of glutathione .
24115750	0	Oatp1a1	0,7	PDZK1	17,22	Oatp1a1	PDZK1	28248(Tax:10090)	59020(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins .
25280775	0	Oatp1b2	113,120	Nrf2	78,82	Oatp1b2	Nrf2	28253(Tax:10090)	18024(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Protection against phalloidin-induced liver_injury by oleanolic_acid involves Nrf2 activation and suppression of Oatp1b2 .
18492796	0	Oatp1b2	63,70	organic_anion-transporting_polypeptide_1b2	19,61	Oatp1b2	organic anion-transporting polypeptide 1b2	28253(Tax:10090)	28253(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the murine organic_anion-transporting_polypeptide_1b2 -LRB- Oatp1b2 -RRB- in drug disposition and hepatotoxicity .
25088042	0	Oatp1d1	97,104	Slco1d1	106,113	Oatp1d1	Slco1d1	326845(Tax:7955)	326845(Tax:7955)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Interaction of environmental contaminants with zebrafish organic anion transporting polypeptide , Oatp1d1 -LRB- Slco1d1 -RRB- .
15483194	0	Oatp4	67,72	organic_anion-transporting_polypeptide_4	25,65	Oatp4	organic anion-transporting polypeptide 4	28253(Tax:10090)	28253(Tax:10090)	Gene	Gene	Down-regulation|dep|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of mouse organic_anion-transporting_polypeptide_4 -LRB- Oatp4 ; Oatp1b2 ; Slc21a10 -RRB- mRNA by lipopolysaccharide through the toll-like_receptor_4 -LRB- TLR4 -RRB- .
10838093	0	Oatp4	60,65	rlst-1	135,141	Oatp4	rlst-1	58978(Tax:10116)	58978(Tax:10116)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of organic_anion_transporting_polypeptide_4 -LRB- Oatp4 -RRB- as a major full-length isoform of the liver-specific_transporter-1 -LRB- rlst-1 -RRB- in rat liver .
11549696	0	Ob-R	47,51	leptin	89,95	Ob-R	leptin	3953	3952	Gene	Gene	and_leptin_receptor|appos|START_ENTITY _|dobj|and_leptin_receptor _|nmod|fibroblasts fibroblasts|dep|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Expression of leptin _ -LRB- Ob -RRB- _ and_leptin_receptor -LRB- Ob-R -RRB- in human fibroblasts : regulation of leptin secretion by insulin .
23558862	0	Ob-R	17,21	leptin	49,55	Ob-R	leptin	3953	3952	Gene	Gene	Leptin_receptor|appos|START_ENTITY mRNA|nsubj|Leptin_receptor mRNA|dobj|concentration concentration|compound|END_ENTITY	Leptin_receptor -LRB- Ob-R -RRB- mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal_cancer .
11159367	0	Ob-R	58,62	leptin_receptor	41,56	Ob-R	leptin receptor	24536(Tax:10116)	24536(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Developmental and hormonal regulation of leptin_receptor -LRB- Ob-R -RRB- messenger ribonucleic acid expression in rat testis .
14527166	0	Ob-R	31,35	leptin_receptor	14,29	Ob-R	leptin receptor	16847(Tax:10090)	16847(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of leptin_receptor -LRB- Ob-R -RRB- isoforms and signal transducers and activators of transcription -LRB- STATs -RRB- mRNAs in the mouse taste buds .
18245367	0	Obp57d	54,60	odorant-binding_protein	23,46	Obp57d	odorant-binding protein	246671(Tax:7227)	246618(Tax:7227)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Rapid evolution of two odorant-binding_protein genes , Obp57d and Obp57e , in the Drosophila_melanogaster species group .
18670137	0	Obp57d	70,76	odorant-binding_protein	39,62	Obp57d	odorant-binding protein	246671(Tax:7227)	246618(Tax:7227)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Behavioral analyses of mutants for two odorant-binding_protein genes , Obp57d and Obp57e , in Drosophila_melanogaster .
26971330	0	Oca2	83,87	TBX2	25,29	Oca2	TBX2	18431(Tax:10090)	21385(Tax:10090)	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2 .
26731658	0	Occludin	28,36	Adipose_Differentiation-Related_Protein	72,111	Occludin	Adipose Differentiation-Related Protein	100506658	123	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Hepatitis_C_Virus Increases Occludin Expression via the Upregulation of Adipose_Differentiation-Related_Protein .
26305039	0	Occludin	49,57	Prolactin	29,38	Occludin	Prolactin	83497(Tax:10116)	24683(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Psychological Stress-Derived Prolactin Modulates Occludin Expression in Vaginal Epithelial Cells to Compromise Barrier Function .
26305039	0	Occludin	49,57	Prolactin	29,38	Occludin	Prolactin	83497(Tax:10116)	24683(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Psychological Stress-Derived Prolactin Modulates Occludin Expression in Vaginal Epithelial Cells to Compromise Barrier Function .
11997177	0	Oct-1	36,41	Androgen_receptor	0,17	Oct-1	Androgen receptor	18986(Tax:10090)	11835(Tax:10090)	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Androgen_receptor interactions with Oct-1 and Brn-1 are physically and functionally distinct .
8999951	0	Oct-1	0,5	C/EBP	42,47	Oct-1	C/EBP	5451	1050	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Oct-1 and CCAAT/enhancer-binding _ protein -LRB- C/EBP -RRB- bind to overlapping elements within the interleukin-8 promoter .
16616894	0	Oct-1	73,78	CD45	51,55	Oct-1	CD45	18986(Tax:10090)	19264(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|END_ENTITY	Differential lineage-specific regulation of murine CD45 transcription by Oct-1 and PU .1 .
19118657	0	Oct-1	15,20	CDKN1A	42,48	Oct-1	CDKN1A	6580	1026	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Oct-1 in the regulation of CDKN1A in response to clinically relevant doses of ionizing radiation .
1534100	0	Oct-1	68,73	Cr2	91,94	Oct-1	Cr2	18986(Tax:10090)	12902(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Identification of sites for distinct DNA binding proteins including Oct-1 and Oct-2 in the Cr2 gene .
12697656	0	Oct-1	62,67	FcepsilonRI	20,31	Oct-1	FcepsilonRI	6580	2205	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of human FcepsilonRI beta chain gene expression by Oct-1 .
24613343	0	Oct-1	0,5	IL-17	16,21	Oct-1	IL-17	5451	3605	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells .
16173915	0	Oct-1	94,99	LOX-1	57,62	Oct-1	LOX-1	5451	4973	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- transcriptional regulation by Oct-1 in human endothelial cells : implications for atherosclerosis .
16173915	0	Oct-1	94,99	Lectin-like_oxidized_low-density_lipoprotein_receptor-1	0,55	Oct-1	Lectin-like oxidized low-density lipoprotein receptor-1	5451	4973	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	Lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- transcriptional regulation by Oct-1 in human endothelial cells : implications for atherosclerosis .
23172665	0	Oct-1	69,74	STAT3	0,5	Oct-1	STAT3	5451	6774	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1 .
7642649	0	Oct-1	15,20	TFIIB	26,31	Oct-1	TFIIB	5451	2959	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Oct-1 with TFIIB .
22310390	0	Oct-1	69,74	U6_snRNA	29,37	Oct-1	U6 snRNA	6580	26827	Gene	Gene	promoter|nmod|START_ENTITY promoter|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of human U6_snRNA promoter by p38 kinase through Oct-1 .
11096094	0	Oct-1	0,5	androgen_receptor	36,53	Oct-1	androgen receptor	20517(Tax:10090)	11835(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Oct-1 preferentially interacts with androgen_receptor in a DNA-dependent manner that facilitates recruitment of SRC-1 .
16158334	0	Oct-1	84,89	angiotensin_II-induced_SP-1_and_AP-1	32,68	Oct-1	angiotensin II-induced SP-1 and AP-1	24904(Tax:10116)	24516(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Heat_shock treatment suppresses angiotensin_II-induced_SP-1_and_AP-1 and stimulates Oct-1 DNA-binding activity in heart .
22349263	0	Oct-1	0,5	iNOS	98,102	Oct-1	iNOS	6580	4843	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|xcomp|control control|dobj|transcription transcription|nmod|END_ENTITY	Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS .
26271992	0	Oct-1	130,135	iNOS	40,44	Oct-1	iNOS	5451	4843	Gene	Gene	interfering|nmod|START_ENTITY forms|advcl|interfering forms|dobj|transcription transcription|amod|complex complex|nmod|Oct-1 Oct-1|nmod|promoter promoter|amod|END_ENTITY	Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1 .
26271992	0	Oct-1	27,32	iNOS	40,44	Oct-1	iNOS	5451	4843	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1 .
11937630	0	Oct-2	0,5	CD36	16,20	Oct-2	CD36	18987(Tax:10090)	12491(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Oct-2 regulates CD36 gene expression via a consensus octamer , which excludes the co-activator OBF-1 .
12356675	0	Oct-2	72,77	CD36	27,31	Oct-2	CD36	18987(Tax:10090)	12491(Tax:10090)	Gene	Gene	dependence|compound|START_ENTITY regulation|dep|dependence regulation|nmod|expression expression|nummod|END_ENTITY	Differential regulation of CD36 expression in antigen-presenting cells : Oct-2 dependence in B lymphocytes but not dendritic cells or macrophages .
7543064	0	Oct-2	88,93	CD36	18,22	Oct-2	CD36	18987(Tax:10090)	12491(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY Identification|amod|dependent Identification|nmod|END_ENTITY	Identification of CD36 as the first gene dependent on the B-cell differentiation factor Oct-2 .
23960236	0	Oct-2	22,27	MiR-210	0,7	Oct-2	MiR-210	18987(Tax:10090)	387206(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	MiR-210 is induced by Oct-2 , regulates B cells , and inhibits autoantibody production .
9360945	0	Oct-2	51,56	NF-kappaB	21,30	Oct-2	NF-kappaB	5452	4790	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes .
19279235	0	Oct-2	22,27	iNOS	57,61	Oct-2	iNOS	5452	4843	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin_A .
26271992	0	Oct-2	0,5	iNOS	40,44	Oct-2	iNOS	5452	4843	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|transcription transcription|amod|complex complex|nmod|Oct-1 Oct-1|nmod|promoter promoter|amod|END_ENTITY	Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1 .
17107342	0	Oct-2	17,22	resistin	71,79	Oct-2	resistin	18987(Tax:10090)	57264(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	A novel role for Oct-2 in the lipopolysaccharide-mediated induction of resistin gene expression in RAW264 .7 cells .
8607968	0	Oct-3	100,105	proto-oncogene_c-mos	54,74	Oct-3	proto-oncogene c-mos	18999(Tax:10090)	17451(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Primate reproductive organs reveal a novel pattern of proto-oncogene_c-mos and transcription factor Oct-3 mRNA expression .
15467907	0	Oct-4	35,40	CD133	70,75	Oct-4	CD133	5460	8842	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|cells cells|nummod|END_ENTITY	Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood .
16510872	0	Oct-4	21,26	HIF-2alpha	0,10	Oct-4	HIF-2alpha	5460	2034	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	HIF-2alpha regulates Oct-4 : effects of hypoxia on stem cell function , embryonic development , and tumor growth .
18191611	0	Oct-4	69,74	Pyruvate_kinase_isozyme_type_M2	0,31	Oct-4	Pyruvate kinase isozyme type M2	5460	5315	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pyruvate_kinase_isozyme_type_M2 -LRB- PKM2 -RRB- interacts and cooperates with Oct-4 in regulating transcription .
19477878	0	Oct-4	0,5	Stella	34,40	Oct-4	Stella	100846986	73708(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Oct-4 regulates the expression of Stella and Foxj2 at the Nanog locus : implications for the developmental competence of mouse oocytes .
24700702	0	Oct-4	54,59	b-catenin	28,37	Oct-4	b-catenin	5460	1499	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Association of differential b-catenin expression with Oct-4 and Nanog in oral_squamous_cell_carcinoma and their correlation with clinicopathological factors and prognosis .
15713637	0	Oct-6	69,74	Brn-1	33,38	Oct-6	Brn-1	18991(Tax:10090)	18993(Tax:10090)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination .
7791781	0	Oct-6	60,65	Tst-1	54,59	Oct-6	Tst-1	5453	100526790	Gene	Gene	interaction|dep|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction between the POU domain protein Tst-1 / Oct-6 and the high-mobility-group protein HMG-I/Y .
26481684	0	Oct1	0,4	CD4	44,47	Oct1	CD4	5451	920	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|compound|END_ENTITY	Oct1 and OCA-B are selectively required for CD4 memory T cell function .
15458920	0	Oct1	46,50	Slc22a1	37,44	Oct1	Slc22a1	20517(Tax:10090)	20517(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of murine Slc22a1 -LRB- Oct1 -RRB- by peroxisome_proliferator_agonist_receptor-alpha and - gamma .
19528230	0	Oct3/4	14,20	Dax1	0,4	Oct3/4	Dax1	5460	190	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells .
25727014	0	Oct3/4	0,6	E2F3a	40,45	Oct3/4	E2F3a	18999(Tax:10090)	13557(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Oct3/4 directly regulates expression of E2F3a in mouse embryonic stem cells .
12665572	0	Oct3/4	27,33	Fbx15	0,5	Oct3/4	Fbx15	18999(Tax:10090)	50764(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development .
16954384	0	Oct3/4	21,27	Klf4	0,4	Oct3/4	Klf4	5460	9314	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells .
23255092	0	Oct4	40,44	BMP4	16,20	Oct4	BMP4	5460	652	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Lin28 regulates BMP4 and functions with Oct4 to affect ovarian_tumor microenvironment .
19536159	0	Oct4	24,28	Ctcf	44,48	Oct4	Ctcf	18999(Tax:10090)	13018(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting .
20943815	0	Oct4	18,22	Dax1	0,4	Oct4	Dax1	18999(Tax:10090)	11614(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA .
22795133	0	Oct4	0,4	Dnmt1	33,38	Oct4	Dnmt1	5460	1786	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells .
19811652	0	Oct4	46,50	ERG-associated_protein_with_SET_domain	0,38	Oct4	ERG-associated protein with SET domain	5460	9869	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	ERG-associated_protein_with_SET_domain -LRB- ESET -RRB- - Oct4 interaction regulates pluripotency and represses the trophectoderm lineage .
18957414	0	Oct4	16,20	Esrrb	0,5	Oct4	Esrrb	100846986	26380(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells .
18662995	0	Oct4	46,50	Estrogen-related_receptor_beta	0,30	Oct4	Estrogen-related receptor beta	5460	2103	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Estrogen-related_receptor_beta interacts with Oct4 to positively regulate Nanog gene expression .
26769970	0	Oct4	42,46	Germ_Cell_Nuclear_Factor	0,24	Oct4	Germ Cell Nuclear Factor	5460	2649	Gene	Gene	Expression|compound|START_ENTITY Represses|dobj|Expression Represses|nsubj|END_ENTITY	Germ_Cell_Nuclear_Factor -LRB- GCNF -RRB- Represses Oct4 Expression and Globally Modulates Gene Expression in Human Embryonic Stem -LRB- hES -RRB- Cells .
23495099	0	Oct4	0,4	Hmgb2	22,27	Oct4	Hmgb2	100846986	97165(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency .
19816951	0	Oct4	29,33	Klf4	0,4	Oct4	Klf4	100846986	16600(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming .
23255092	0	Oct4	40,44	Lin28	0,5	Oct4	Lin28	5460	79727	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Lin28 regulates BMP4 and functions with Oct4 to affect ovarian_tumor microenvironment .
23052207	0	Oct4	27,31	MBD6	0,4	Oct4	MBD6	5460	114785	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MBD6 is a direct target of Oct4 and controls the stemness and differentiation of adipose tissue-derived stem cells .
18687992	0	Oct4	45,49	Nanog	17,22	Oct4	Nanog	5460	79923	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Zfp143 regulates Nanog through modulation of Oct4 binding .
20096661	0	Oct4	39,43	Nr5a2	21,26	Oct4	Nr5a2	100846986	26424(Tax:10090)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells .
18212089	0	Oct4	103,107	POU5F1	96,102	Oct4	POU5F1	5460	5460	Gene	Gene	complexes|appos|START_ENTITY complexes|amod|END_ENTITY	High-throughput biochemical analysis of in vivo location data reveals novel distinct classes of POU5F1 -LRB- Oct4 -RRB- / DNA complexes .
25509123	0	Oct4	48,52	POU5F1	54,60	Oct4	POU5F1	18999(Tax:10090)	18999(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Investigation of transcriptional regulation of Oct4 -LRB- POU5F1 -RRB- gene with distal enhancer -RSB- .
17187077	0	Oct4	63,67	Pml	44,47	Oct4	Pml	5460	5371	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells .
11861474	0	Oct4	101,105	Pou2	75,79	Oct4	Pou2	5460	30333(Tax:7955)	Gene	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	The zebrafish spiel-ohne-grenzen -LRB- spg -RRB- gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain , and for pre-gastrula morphogenesis .
20080709	0	Oct4	36,40	Stk40	0,5	Oct4	Stk40	100846986	74178(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation .
21725619	0	Oct4	70,74	TCF3	0,4	Oct4	TCF3	100846986	21415(Tax:10090)	Gene	Gene	down-regulation|nmod|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	TCF3 inhibits F9 embryonal_carcinoma growth by the down-regulation of Oct4 .
23254757	0	Oct4	0,4	Tet2	54,58	Oct4	Tet2	100846986	214133(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Oct4 and the small molecule inhibitor , SC1 , regulates Tet2 expression in mouse embryonic stem cells .
22281008	0	Oct4	62,66	Translationally_controlled_tumor_protein	0,40	Oct4	Translationally controlled tumor protein	100846986	22070(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Translationally_controlled_tumor_protein -LRB- TCTP -RRB- downregulates Oct4 expression in mouse pluripotent cells .
26173898	0	Oct4	125,129	octamer-binding_transcription_factor_4	85,123	Oct4	octamer-binding transcription factor 4	18999(Tax:10090)	18999(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Distribution pattern of cytoplasmic organelles , spindle integrity , oxidative stress , octamer-binding_transcription_factor_4 -LRB- Oct4 -RRB- expression and developmental potential of oocytes following multiple superovulation .
19710692	0	Octamer_binding_protein_2	0,25	PD-L2	43,48	Octamer binding protein 2	PD-L2	5452	80380	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Octamer_binding_protein_2 -LRB- Oct2 -RRB- regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique , intronic promoter .
23112997	0	Oculocutaneous_Albinism_Type1A	20,50	OCA1A	52,57	Oculocutaneous Albinism Type1A	OCA1A	7299	7299	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Genetic Analysis of Oculocutaneous_Albinism_Type1A -LRB- OCA1A -RRB- in an Iranian Family .
18804520	0	Odd-skipped_related_1	0,21	Runx2	54,59	Odd-skipped related 1	Runx2	23967(Tax:10090)	12393(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Odd-skipped_related_1 gene expression is regulated by Runx2 and Ikzf1 transcription factors .
10373309	0	Odf1	62,66	Spag4	0,5	Odf1	Spag4	4956	6676	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Spag4 , a novel sperm protein , binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme .
25352170	0	Odf2	67,71	Pax6	0,4	Odf2	Pax6	4957	5080	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Pax6 controls centriole maturation in cortical progenitors through Odf2 .
19503746	0	Ogg1	44,48	8-oxoguanine_DNA_glycosylase	14,42	Ogg1	8-oxoguanine DNA glycosylase	18294(Tax:10090)	18294(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of 8-oxoguanine_DNA_glycosylase -LRB- Ogg1 -RRB- in mouse retina .
14989603	0	Olig1	66,71	oligodendrocyte_transcription_factor_1	26,64	Olig1	oligodendrocyte transcription factor 1	116448	116448	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of the oligodendrocyte_transcription_factor_1 -LRB- Olig1 -RRB- in brain_tumors .
27067865	0	Olig2	24,29	Brg1	0,4	Olig2	Brg1	50913(Tax:10090)	20586(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Brg1 directly regulates Olig2 transcription and is required for oligodendrocyte progenitor cell specification .
16815098	0	Olig2	42,47	Olig2	74,79	Olig2	Olig2	50913(Tax:10090)	50913(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of the basic helix-loop-factor Olig2 in the developing retina : Olig2 as a new marker for retinal progenitors and late-born cells .
16815098	0	Olig2	74,79	Olig2	42,47	Olig2	Olig2	50913(Tax:10090)	50913(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of the basic helix-loop-factor Olig2 in the developing retina : Olig2 as a new marker for retinal progenitors and late-born cells .
20959288	0	Olig2	0,5	Sox10	16,21	Olig2	Sox10	10215	6663	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer .
25324439	0	Omentin	0,7	insulin	89,96	Omentin	insulin	55600	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Omentin , an adipokine with insulin-sensitizing properties , is negatively associated with insulin resistance in normal gestation .
10937437	0	OmpT	0,4	chloramphenicol_acetyltransferase	65,98	OmpT	chloramphenicol acetyltransferase	3853531(Tax:562)	8319152(Tax:562)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|response response|nmod|END_ENTITY	OmpT expression and activity increase in response to recombinant chloramphenicol_acetyltransferase overexpression and heat_shock in E. _ coli .
25692402	0	Oncostatin-M	76,88	CXCL5	29,34	Oncostatin-M	CXCL5	18413(Tax:10090)	20311(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Induction of STAT3-Dependent CXCL5 Expression and Neutrophil Recruitment by Oncostatin-M during Pneumonia .
14603252	0	Oncostatin-M	0,12	vascular_endothelial_growth_factor	26,60	Oncostatin-M	vascular endothelial growth factor	5008	7422	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Oncostatin-M induction of vascular_endothelial_growth_factor expression in astroglioma cells .
26712749	0	Oncostatin_M	20,32	Adiponectin	0,11	Oncostatin M	Adiponectin	5008	9370	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Adiponectin Induces Oncostatin_M Expression in Osteoblasts through the PI3K/Akt Signaling Pathway .
17114436	0	Oncostatin_M	0,12	CCL21	22,27	Oncostatin M	CCL21	18413(Tax:10090)	6366	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Oncostatin_M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph_nodes .
22814105	0	Oncostatin_M	0,12	CTGF	37,41	Oncostatin M	CTGF	5008	1490	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Oncostatin_M inhibits TGF-b1-induced CTGF expression via STAT3 in human proximal tubular cells .
20680966	0	Oncostatin_M	0,12	CXCL10	37,43	Oncostatin M	CXCL10	5008	3627	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Oncostatin_M synergistically induces CXCL10 and ICAM-1 expression in IL-1beta-stimulated-human gingival fibroblasts .
24060241	0	Oncostatin_M	0,12	E-cadherin	76,86	Oncostatin M	E-cadherin	5008	999	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Oncostatin_M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation .
7500025	0	Oncostatin_M	0,12	Grb2	36,40	Oncostatin M	Grb2	5008	2885	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	Oncostatin_M induces association of Grb2 with Janus kinase JAK2 in multiple_myeloma cells .
20335534	0	Oncostatin_M	70,82	IL-17A	55,61	Oncostatin M	IL-17A	5008	3605	Gene	Gene	IL-1|appos|START_ENTITY IL-1|compound|END_ENTITY	Skin_Inflammation Induced by the Synergistic Action of IL-17A , IL-22 , Oncostatin_M , IL-1 -LCB- alpha -RCB- , and TNF - -LCB- alpha -RCB- Recapitulates Some Features of Psoriasis .
26251474	0	Oncostatin_M	0,12	IL-33	21,26	Oncostatin M	IL-33	18413(Tax:10090)	77125(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Oncostatin_M induces IL-33 expression in liver endothelial cells in mice and expands ST2 + CD4 + lymphocytes .
26251474	0	Oncostatin_M	0,12	IL-33	21,26	Oncostatin M	IL-33	18413(Tax:10090)	77125(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Oncostatin_M induces IL-33 expression in liver endothelial cells in mice and expands ST2 + CD4 + lymphocytes .
9548508	0	Oncostatin_M	0,12	IL-6	58,62	Oncostatin M	IL-6	5008	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Oncostatin_M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells .
8598483	0	Oncostatin_M	0,12	IL-8_and_granulocyte-macrophage_colony-stimulating_factor	49,106	Oncostatin M	IL-8 and granulocyte-macrophage colony-stimulating factor	5008	3576;1437	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Oncostatin_M inhibits IL-1-induced expression of IL-8_and_granulocyte-macrophage_colony-stimulating_factor by synovial and lung fibroblasts .
26304992	0	Oncostatin_M	21,33	Osteopontin	0,11	Oncostatin M	Osteopontin	5008	6696	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Osteopontin Promotes Oncostatin_M Production in Human Osteoblasts : Implication of Rheumatoid_Arthritis Therapy .
26304992	0	Oncostatin_M	21,33	Osteopontin	0,11	Oncostatin M	Osteopontin	5008	6696	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Osteopontin Promotes Oncostatin_M Production in Human Osteoblasts : Implication of Rheumatoid_Arthritis Therapy .
17028188	0	Oncostatin_M	0,12	RAS/ERK	47,54	Oncostatin M	RAS/ERK	18413(Tax:10090)	26413(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Oncostatin_M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways .
21481226	0	Oncostatin_M	0,12	STAT3	22,27	Oncostatin M	STAT3	5008	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activation activation|nummod|END_ENTITY	Oncostatin_M promotes STAT3 activation , VEGF production , and invasion in osteosarcoma cell lines .
22814105	0	Oncostatin_M	0,12	STAT3	57,62	Oncostatin M	STAT3	5008	6774	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Oncostatin_M inhibits TGF-b1-induced CTGF expression via STAT3 in human proximal tubular cells .
24060241	0	Oncostatin_M	0,12	STAT3	119,124	Oncostatin M	STAT3	5008	6774	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|compound|END_ENTITY	Oncostatin_M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation .
25954856	0	Oncostatin_M	0,12	STAT3	23,28	Oncostatin M	STAT3	5008	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Oncostatin_M activates STAT3 to promote endometrial_cancer_invasion and angiogenesis .
26996579	0	Oncostatin_M	76,88	STAT3	0,5	Oncostatin M	STAT3	5008	6774	Gene	Gene	Implicated|nmod|START_ENTITY Implicated|nsubjpass|END_ENTITY	STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin_M through Induction of Matrix_Metalloproteinases_2_and_9 .
1421089	0	Oncostatin_M	0,12	VIP	23,26	Oncostatin M	VIP	5008	7432	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Oncostatin_M regulates VIP expression in a human neuroblastoma cell line .
17081797	0	Oncostatin_M	0,12	adiponectin	23,34	Oncostatin M	adiponectin	5008	9370	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Oncostatin_M decreases adiponectin expression and induces dedifferentiation of adipocytes by JAK3 - and MEK-dependent pathways .
9461605	0	Oncostatin_M	0,12	alpha1-antichymotrypsin	87,110	Oncostatin M	alpha1-antichymotrypsin	5008	12	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Oncostatin_M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes .
9133674	0	Oncostatin_M	0,12	basic_fibroblast_growth_factor	21,51	Oncostatin M	basic fibroblast growth factor	5008	281161(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Oncostatin_M induces basic_fibroblast_growth_factor expression in endothelial cells and promotes endothelial cell proliferation , migration and spindle morphology .
9478976	0	Oncostatin_M	0,12	c-Fos	24,29	Oncostatin M	c-Fos	18413(Tax:10090)	14281(Tax:10090)	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Oncostatin_M stimulates c-Fos to bind a transcriptionally responsive AP-1 element within the tissue_inhibitor_of_metalloproteinase-1 promoter .
9683456	0	Oncostatin_M	0,12	endothelin-1	23,35	Oncostatin M	endothelin-1	5008	1906	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Oncostatin_M regulates endothelin-1 production in human endothelial cells .
12496442	0	Oncostatin_M	0,12	eotaxin	23,30	Oncostatin M	eotaxin	18413(Tax:10090)	20292(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Oncostatin_M regulates eotaxin expression in fibroblasts and eosinophilic inflammation in C57BL/6 mice .
19799897	0	Oncostatin_M	0,12	eotaxin	50,57	Oncostatin M	eotaxin	18413(Tax:10090)	20292(Tax:10090)	Gene	Gene	START_ENTITY|dep|responses responses|compound|END_ENTITY	Oncostatin_M -LRB- OSM -RRB- primes IL-13 - _ and_IL-4-induced eotaxin responses in fibroblasts : regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1 .
8145046	0	Oncostatin_M	0,12	gp130	147,152	Oncostatin M	gp130	5008	3572	Gene	Gene	induce|advmod|START_ENTITY induce|dobj|proliferation proliferation|nmod|cells cells|nmod|transducer transducer|appos|END_ENTITY	Oncostatin_M , leukemia_inhibitory_factor , and interleukin_6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp130 .
8157624	0	Oncostatin_M	0,12	gp130	31,36	Oncostatin M	gp130	5008	3572	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Oncostatin_M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin_M receptors .
10590238	0	Oncostatin_M	0,12	interleukin-6	21,34	Oncostatin M	interleukin-6	5008	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Oncostatin_M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta .
10899931	0	Oncostatin_M	0,12	interleukin-6	27,40	Oncostatin M	interleukin-6	5008	3569	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Oncostatin_M regulation of interleukin-6 expression in astrocytes : biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38 .
8145046	0	Oncostatin_M	0,12	leukemia_inhibitory_factor	14,40	Oncostatin M	leukemia inhibitory factor	5008	3976	Gene	Gene	induce|advmod|START_ENTITY induce|nsubj|END_ENTITY	Oncostatin_M , leukemia_inhibitory_factor , and interleukin_6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp130 .
7696181	0	Oncostatin_M	0,12	low_density_lipoprotein_receptor	23,55	Oncostatin M	low density lipoprotein receptor	5008	3949	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	Oncostatin_M activates low_density_lipoprotein_receptor gene transcription in sterol-repressed liver cells .
21399864	0	Oncostatin_M	0,12	signal_transducer_and_activator_of_transcription_3	68,118	Oncostatin M	signal transducer and activator of transcription 3	5008	6774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Oncostatin_M promotes proliferation of ovarian_cancer cells through signal_transducer_and_activator_of_transcription_3 .
14673992	0	Oncostatin_M	0,12	tumor_necrosis_factor_alpha	33,60	Oncostatin M	tumor necrosis factor alpha	18413(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Oncostatin_M in combination with tumor_necrosis_factor_alpha induces cartilage_damage and matrix metalloproteinase expression in vitro and in vivo .
21965736	0	Oncostatin_M	0,12	u-PA	29,33	Oncostatin M	u-PA	5008	5328	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	Oncostatin_M and IL-6 induce u-PA and VEGF in prostate_cancer cells and correlate in vivo .
1953736	0	Oncostatin_M	0,12	urokinase-type_plasminogen_activator	24,60	Oncostatin M	urokinase-type plasminogen activator	5008	5328	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Oncostatin_M stimulates urokinase-type_plasminogen_activator activity in human synovial fibroblasts .
15381696	0	Onecut-1	53,61	hepatocyte_nuclear_factor-6	25,52	Onecut-1	hepatocyte nuclear factor-6	15379(Tax:10090)	15379(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	The transcription factor hepatocyte_nuclear_factor-6 / Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm .
8906359	0	Op18	61,65	pr22	55,59	Op18	pr22	3925	3925	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional and post-transcriptional regulation of pr22 -LRB- Op18 -RRB- with proliferation control .
20436456	0	Opa1	40,44	Bnip3	13,18	Opa1	Bnip3	4976	664	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial_fragmentation and apoptosis by distinct mechanisms .
23878241	0	Opa1	23,27	Higd-1a	0,7	Opa1	Higd-1a	4976	25994	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria .
8917316	0	Opaque-2	80,88	zein	56,60	Opaque-2	zein	542375(Tax:4577)	732802(Tax:4577)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The role of multiple binding sites in the activation of zein gene expression by Opaque-2 .
20943750	0	Opdc	4,8	Pax2	30,34	Opdc	Pax2	18504(Tax:10090)	5076	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	The Opdc missense mutation of Pax2 has a milder than loss-of-function phenotype .
21104417	0	Opi1	63,67	Sin3	25,29	Opi1	Sin3	856366(Tax:4932)	854158(Tax:4932)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Pleiotropic corepressors Sin3 and Ssn6 interact with repressor Opi1 and negatively regulate transcription of genes required for phospholipid biosynthesis in the yeast Saccharomyces_cerevisiae .
10464356	0	Opioid_receptor-like	0,20	ORL1	22,26	Opioid receptor-like	ORL1	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor distribution in the rat central nervous system : comparison of ORL1 receptor mRNA expression with -LRB- 125 -RRB- I - -LSB- -LRB- 14 -RRB- Tyr -RSB- - orphanin_FQ binding .
16800795	0	Opioid_receptor-like	0,20	ORL1	22,26	Opioid receptor-like	ORL1	4987	4987	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor utilizes both G -LRB- oA -RRB- _ and_G -LRB- oB -RRB- for signal transduction .
23644099	0	Opn	106,109	Vdr	69,72	Opn	Vdr	20750(Tax:10090)	22337(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn during soft tissue calcification .
16644048	0	Oprm	92,96	mu-opioid_receptor	67,85	Oprm	mu-opioid receptor	18390(Tax:10090)	18390(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and functional significance of polymorphisms in the mu-opioid_receptor gene -LRB- Oprm -RRB- promoter of C57BL/6 and DBA/2 mice .
14638744	0	Opticin	0,7	growth_hormone	22,36	Opticin	growth hormone	395130(Tax:9031)	378781(Tax:9031)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Opticin binds retinal growth_hormone in the embryonic vitreous .
17054946	0	Optimedin	0,9	N-cadherin	32,42	Optimedin	N-cadherin	252920(Tax:10116)	83501(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells .
22854040	0	Optineurin	0,10	Rab8	45,49	Optineurin	Rab8	10133	4218	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17 .
22854040	0	Optineurin	0,10	TBC1D17	83,90	Optineurin	TBC1D17	10133	79735	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17 .
26976762	0	Optineurin	31,41	TBK1	14,18	Optineurin	TBK1	10133	29110	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway .
22860700	0	Optineurin	0,10	TDP-43	42,48	Optineurin	TDP-43	10133	23435	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis .
26376340	0	Optineurin	163,173	Tbk1	61,65	Optineurin	Tbk1	10133	29110	Gene	Gene	Phosphorylation|nmod|START_ENTITY Formation|nmod|Phosphorylation Activates|nmod|Formation Activates|dobj|END_ENTITY	A Glaucoma-Associated Variant of Optineurin , M98K , Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin .
26376340	0	Optineurin	33,43	Tbk1	61,65	Optineurin	Tbk1	10133	29110	Gene	Gene	M98K|compound|START_ENTITY Variant|nmod|M98K Activates|nsubj|Variant Activates|dobj|END_ENTITY	A Glaucoma-Associated Variant of Optineurin , M98K , Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin .
15837803	0	Optineurin	0,10	myosin_VI	17,26	Optineurin	myosin VI	10133	4646	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Optineurin links myosin_VI to the Golgi complex and is involved in Golgi organization and exocytosis .
26546674	0	Orai1	135,140	Stromal_Interaction_Molecule_1	23,53	Orai1	Stromal Interaction Molecule 1	84876	6786	Gene	Gene	Calcium_Release-Activated_Calcium_Modulator_1|appos|START_ENTITY Binding|nmod|Calcium_Release-Activated_Calcium_Modulator_1 Binding|nmod|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
23307288	0	Orai1	27,32	Ubiquilin_1	0,11	Orai1	Ubiquilin 1	84876	29979	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ubiquilin_1 interacts with Orai1 to regulate calcium mobilization .
23447534	0	Orai1	45,50	stromal_interaction_molecule_1	79,109	Orai1	stromal interaction molecule 1	84876	6786	Gene	Gene	protein|amod|START_ENTITY protein|acl|interacting interacting|nmod|END_ENTITY	Differential roles of the C and N termini of Orai1 protein in interacting with stromal_interaction_molecule_1 -LRB- STIM1 -RRB- for Ca2 + release-activated Ca2 + -LRB- CRAC -RRB- channel activation .
24996186	0	Orai1	100,105	stromal_interaction_molecule_1	52,82	Orai1	stromal interaction molecule 1	84876	6786	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Atomic force microscopy -LRB- AFM -RRB- imaging suggests that stromal_interaction_molecule_1 -LRB- STIM1 -RRB- binds to Orai1 with sixfold symmetry .
21947279	0	Orc2	24,28	Plk1	0,4	Orc2	Plk1	4999	5347	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress .
23300462	0	Orch3	18,23	kinesin_family_member_1C	92,116	Orch3	kinesin family member 1C	112260(Tax:10090)	16562(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Orch3 , a locus controlling dominant resistance to autoimmune_orchitis , as kinesin_family_member_1C .
12690115	0	Orexin_1_receptor	26,43	CB1	113,116	Orexin 1 receptor	CB1	3061	1268	Gene	Gene	Hypersensitization|nmod|START_ENTITY Hypersensitization|dep|evidence evidence|nmod|cross-talk cross-talk|acl|blocked blocked|nmod|antagonist antagonist|compound|END_ENTITY	Hypersensitization of the Orexin_1_receptor by the CB1 receptor : evidence for cross-talk blocked by the specific CB1 antagonist , SR141716 .
12690115	0	Orexin_1_receptor	26,43	CB1	51,54	Orexin 1 receptor	CB1	3061	1268	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Hypersensitization of the Orexin_1_receptor by the CB1 receptor : evidence for cross-talk blocked by the specific CB1 antagonist , SR141716 .
17192702	0	Orexin_A	0,8	GnRH	17,21	Orexin A	GnRH	25723(Tax:10116)	25194(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Orexin_A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons .
17192702	0	Orexin_A	0,8	GnRH	76,80	Orexin A	GnRH	25723(Tax:10116)	25194(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|neurons neurons|amod|END_ENTITY	Orexin_A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons .
26653571	0	Orexin_Type_2	129,142	OX2-R	144,149	Orexin Type 2	OX2-R	3062	3062	Gene	Gene	Receptors|compound|START_ENTITY Receptors|appos|END_ENTITY	Activation of Medulla-Projecting Perifornical Neurons Modulates the Adrenal Sympathetic Response to Hypoglycemia : Involvement of Orexin_Type_2 -LRB- OX2-R -RRB- Receptors .
22673226	0	Orexin_a	0,8	GnRH	52,56	Orexin a	GnRH	15171(Tax:10090)	14714(Tax:10090)	Gene	Gene	suppresses|compound|START_ENTITY gonadotropin-releasing_hormone|nsubj|suppresses gonadotropin-releasing_hormone|dobj|activity activity|appos|END_ENTITY	Orexin_a suppresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuron activity in the mouse .
26651153	0	Organic_Anion_Transporter-3	80,107	Nedd4-2	21,28	Organic Anion Transporter-3	Nedd4-2	83500(Tax:10116)	291553(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	An Essential Role of Nedd4-2 in the Ubiquitination , Expression , and Function of Organic_Anion_Transporter-3 .
25387129	0	Organic_Anion_Transporting_Polypeptide_1A2	45,87	OATP1A2	89,96	Organic Anion Transporting Polypeptide 1A2	OATP1A2	6579	6579	Gene	Gene	Domain|nmod|START_ENTITY Domain|appos|END_ENTITY	Putative Transmembrane Domain 6 of the Human Organic_Anion_Transporting_Polypeptide_1A2 -LRB- OATP1A2 -RRB- Influences Transporter Substrate Binding , Protein Trafficking , and Quality Control .
7525612	0	Ornithine_decarboxylase	0,23	H-ras	118,123	Ornithine decarboxylase	H-ras	18263(Tax:10090)	15461(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Ornithine_decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines .
8149836	0	Ornithine_decarboxylase	0,23	ODC	25,28	Ornithine decarboxylase	ODC	4953	4953	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Ornithine_decarboxylase -LRB- ODC -RRB- levels in children with reflux_esophagitis .
10047468	0	Ornithine_decarboxylase	0,23	WT1	72,75	Ornithine decarboxylase	WT1	4953	7490	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Ornithine_decarboxylase is a transcriptional target of tumor suppressor WT1 .
21505150	0	Ornithine_decarboxylase	0,23	androgen_receptor	46,63	Ornithine decarboxylase	androgen receptor	18263(Tax:10090)	11835(Tax:10090)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Ornithine_decarboxylase is upregulated by the androgen_receptor in skeletal muscle and regulates myoblast proliferation .
7509717	0	Ornithine_decarboxylase	0,23	keratins_1_and_10	115,132	Ornithine decarboxylase	keratins 1 and 10	18263(Tax:10090)	16678;16661	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|nmod|END_ENTITY	Ornithine_decarboxylase expression in cutaneous_papillomas in SENCAR mice is associated with altered expression of keratins_1_and_10 .
19331812	0	Ornithine_decarboxylase	0,23	rhoA	67,71	Ornithine decarboxylase	rhoA	24609(Tax:10116)	117273(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Ornithine_decarboxylase regulates the activity and localization of rhoA via polyamination .
18177935	0	Ornithine_decarboxylase	0,23	tumor_necrosis_factor_alpha	117,144	Ornithine decarboxylase	tumor necrosis factor alpha	4953	7124	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	Ornithine_decarboxylase interferes with macrophage-like differentiation and matrix_metalloproteinase-9 expression by tumor_necrosis_factor_alpha via NF-kappaB .
3770743	0	Orosomucoid	0,11	ORM1	82,86	Orosomucoid	ORM1	5004	5004	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|END_ENTITY	Orosomucoid -LRB- ORM -RRB- typing by isoelectric focusing : evidence of two structural loci ORM1 and ORM2 .
26740279	0	Orosomucoid_1	16,29	C-C_Chemokine_Receptor_Type_5	38,67	Orosomucoid 1	C-C Chemokine Receptor Type 5	5004	1234	Gene	Gene	Acts|nsubj|START_ENTITY Acts|nmod|END_ENTITY	Fatigue-induced Orosomucoid_1 Acts on C-C_Chemokine_Receptor_Type_5 to Enhance Muscle Endurance .
12151779	0	Orphanin_FQ	0,11	GnRH	21,25	Orphanin FQ	GnRH	25516(Tax:10116)	25194(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Orphanin_FQ inhibits GnRH secretion from rat hypothalamic fragments but not GT1-7 neurons .
11861322	0	Orphanin_FQ	0,11	ORL1	98,102	Orphanin FQ	ORL1	5368	4987	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|receptors receptors|compound|END_ENTITY	Orphanin_FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors .
19190682	0	Orphanin_FQ	26,37	ORL1	65,69	Orphanin FQ	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY inhibits|nsubj|administration inhibits|nmod|receptor receptor|nummod|END_ENTITY	Central administration of Orphanin_FQ inhibits GnRH secretion by ORL1 receptor in the median eminence of freely moving ovariectomized rats .
9051812	0	Orphanin_FQ	0,11	ORL1	47,51	Orphanin FQ	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Orphanin_FQ , agonist of orphan opioid receptor ORL1 , stimulates feeding in rats .
9920456	0	Orphanin_FQ	0,11	nociceptin	12,22	Orphanin FQ	nociceptin	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|END_ENTITY	Orphanin_FQ / nociceptin modulates glutamate - and kainic_acid-induced currents in acutely isolated rat spinal dorsal horn neurons .
9757048	0	Orphanin_FQ	0,11	prolactin	23,32	Orphanin FQ	prolactin	25516(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Orphanin_FQ stimulates prolactin and growth hormone release in male and female rats .
20008573	0	Osa	33,36	CyclinE	52,59	Osa	CyclinE	42130(Tax:7227)	34924(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs .
19306864	0	Osa	0,3	EGFR	122,126	Osa	EGFR	42130(Tax:7227)	37455(Tax:7227)	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	Osa , a subunit of the BAP chromatin-remodelling complex , participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing .
15367582	0	Osh1p	83,88	Nvj1p	0,5	Osh1p	Nvj1p	851286(Tax:4932)	856602(Tax:4932)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Nvj1p is the outer-nuclear-membrane receptor for oxysterol-binding_protein homolog Osh1p in Saccharomyces_cerevisiae .
8804312	0	Oskar	0,5	Vasa	31,35	Oskar	Vasa	41066(Tax:7227)	26067080	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Oskar protein interaction with Vasa represents an essential step in polar granule assembly .
8225587	0	OspC	50,54	p23	45,48	OspC	p23	13917590	8851	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization and expression of p23 -LRB- OspC -RRB- from a North American strain of Borrelia_burgdorferi .
21420399	0	Osr2	0,4	Msx1	53,57	Osr2	Msx1	107587(Tax:10090)	17701(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field .
21420399	0	Osr2	0,4	Pax9	24,28	Osr2	Pax9	107587(Tax:10090)	18511(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field .
19549845	0	Ost3p	62,67	Oxidoreductase	0,14	Ost3p	Oxidoreductase	854252(Tax:4932)	855266(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency .
24415158	0	Osteoactivin	0,12	HSPG	50,54	Osteoactivin	HSPG	93695(Tax:10090)	15529(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Osteoactivin promotes osteoblast adhesion through HSPG and avb1 integrin .
16100390	0	Osteoactivin	0,12	MMP-3	39,44	Osteoactivin	MMP-3	93695(Tax:10090)	17392(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Osteoactivin upregulates expression of MMP-3 and MMP-9 in fibroblasts infiltrated into denervated skeletal muscle in mice .
23437377	0	Osteocalcin	0,11	glucagon-like_peptide-1	31,54	Osteocalcin	glucagon-like peptide-1	12097(Tax:10090)	14526(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Osteocalcin induces release of glucagon-like_peptide-1 and thereby stimulates insulin secretion in mice .
24691732	0	Osteocalcin	0,11	growth_hormone	20,34	Osteocalcin	growth hormone	12097(Tax:10090)	14599(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Osteocalcin induces growth_hormone / insulin-like growth factor-1 system by promoting testosterone synthesis in male mice .
18064667	0	Osteoclast_stimulatory_transmembrane_protein	0,44	RANKL	84,89	Osteoclast stimulatory transmembrane protein	RANKL	74614(Tax:10090)	21943(Tax:10090)	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Osteoclast_stimulatory_transmembrane_protein -LRB- OC-STAMP -RRB- , a novel protein induced by RANKL that promotes osteoclast differentiation .
25676701	0	Osteoclastic_Transmembrane_Protein-Tyrosine_Phosphatase	3,58	EphA4	117,122	Osteoclastic Transmembrane Protein-Tyrosine Phosphatase	EphA4	5800	2043	Gene	Gene	Activity|amod|START_ENTITY Activity|nmod|END_ENTITY	An Osteoclastic_Transmembrane_Protein-Tyrosine_Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts .
15632471	0	Osteoclastogenesis_Inhibitory_Factor	1,37	OPG	63,66	Osteoclastogenesis inhibitory factor	OPG	4982	4982	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	-LSB- Osteoclastogenesis_Inhibitory_Factor -LRB- OCIF -RRB- / Osteoprotegerin -LRB- OPG -RRB- as a new therapeutic agent for osteoporosis -RSB- .
24086840	0	Osteogenic_Protein-1	19,39	OP-1	41,45	Osteogenic Protein-1	OP-1	655	655	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of the Osteogenic_Protein-1 -LRB- OP-1 -RRB- with Age , Cartilage metabolic Markers and Antioxidants in the Osteoarthritic Patients of Sikkim .
20532035	0	Osteogenin	39,49	BMP3	51,55	Osteogenin	BMP3	651	651	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence for positive selection on the Osteogenin -LRB- BMP3 -RRB- gene in human populations .
15993098	0	Osteopontin	0,11	BCR-ABL	30,37	Osteopontin	BCR-ABL	6696	25	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Osteopontin is upregulated by BCR-ABL .
24550510	0	Osteopontin	0,11	CD103	26,31	Osteopontin	CD103	6696	3682	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Osteopontin expression by CD103 - dendritic cells drives intestinal inflammation .
12529435	0	Osteopontin	0,11	CD44	70,74	Osteopontin	CD44	20750(Tax:10090)	12505(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY produces|nsubj|deficiency produces|xcomp|due due|nmod|expression expression|compound|END_ENTITY	Osteopontin deficiency produces osteoclast_dysfunction due to reduced CD44 surface expression .
15325806	0	Osteopontin	0,11	CD44	22,26	Osteopontin	CD44	20750(Tax:10090)	12505(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells .
18997126	0	Osteopontin	0,11	CD44	26,30	Osteopontin	CD44	6696	960	Gene	Gene	combined|nsubj|START_ENTITY combined|nmod|END_ENTITY	Osteopontin combined with CD44 , a novel prognostic biomarker for patients with hepatocellular_carcinoma undergoing curative resection .
22807608	0	Osteopontin	0,11	CD44	64,68	Osteopontin	CD44	20750(Tax:10090)	12505(Tax:10090)	Gene	Gene	growth|compound|START_ENTITY growth|nmod|manner manner|compound|END_ENTITY	Osteopontin increases_hepatocellular_carcinoma cell growth in a CD44 dependant manner .
24531809	0	Osteopontin	0,11	CD44	82,86	Osteopontin	CD44	20750(Tax:10090)	12505(Tax:10090)	Gene	Gene	stimulates|compound|START_ENTITY apoptosis|nsubj|stimulates apoptosis|nmod|myocytes myocytes|nmod|involvement involvement|nmod|receptors receptors|nummod|END_ENTITY	Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors , mitochondrial death pathway , and endoplasmic_reticulum_stress .
15956076	0	Osteopontin	0,11	CEACAM1	54,61	Osteopontin	CEACAM1	6696	634	Gene	Gene	colocalized|nsubjpass|START_ENTITY colocalized|nmod|END_ENTITY	Osteopontin is colocalized with the adhesion molecule CEACAM1 in the extravillous trophoblast of the human placenta and enhances invasion of CEACAM1-expressing placental cells .
25471249	0	Osteopontin	0,11	EZH2	21,25	Osteopontin	EZH2	6696	2146	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Osteopontin Promotes EZH2 Expression and Tumor Progression in Nasopharyngeal_Carcinoma .
26395740	0	Osteopontin	62,73	Glucose-Dependent_Insulinotropic_Polypeptide	0,44	Osteopontin	Glucose-Dependent Insulinotropic Polypeptide	6696	2695	Gene	Gene	Expression|compound|START_ENTITY Stimulates|dobj|Expression Stimulates|nsubj|END_ENTITY	Glucose-Dependent_Insulinotropic_Polypeptide -LRB- GIP -RRB- Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB .
26136997	0	Osteopontin	0,11	HIF-2a	21,27	Osteopontin	HIF-2a	6696	2034	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Osteopontin inhibits HIF-2a mRNA expression in osteoarthritic chondrocytes .
24999034	0	Osteopontin	0,11	HOTAIR	39,45	Osteopontin	HOTAIR	6696	100124700	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Osteopontin enhances the expression of HOTAIR in cancer cells via IRF1 .
21104439	0	Osteopontin	0,11	MMP-2	72,77	Osteopontin	MMP-2	6696	4313	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Osteopontin promotes hepatocellular_carcinoma invasion by up-regulating MMP-2 and uPA expression .
21909361	0	Osteopontin	0,11	MMP-2	52,57	Osteopontin	MMP-2	6696	4313	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Osteopontin enhances the expression and activity of MMP-2 via the SDF-1 / CXCR4 axis in hepatocellular_carcinoma cell lines .
23359766	0	Osteopontin	15,26	OPN	28,31	Osteopontin	OPN	6696	6696	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|appos|END_ENTITY	Expressions of Osteopontin -LRB- OPN -RRB- , a b3 and Pim-1 Associated with Poor Prognosis in Non-small_Cell_Lung_Cancer -LRB- NSCLC -RRB- .
26304992	0	Osteopontin	0,11	Oncostatin_M	21,33	Osteopontin	Oncostatin M	6696	5008	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Osteopontin Promotes Oncostatin_M Production in Human Osteoblasts : Implication of Rheumatoid_Arthritis Therapy .
26304992	0	Osteopontin	0,11	Oncostatin_M	21,33	Osteopontin	Oncostatin M	6696	5008	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Osteopontin Promotes Oncostatin_M Production in Human Osteoblasts : Implication of Rheumatoid_Arthritis Therapy .
24216994	0	Osteopontin	0,11	PC3	86,89	Osteopontin	PC3	6696	5122	Gene	Gene	START_ENTITY|dep|Associations Associations|nmod|Cells Cells|compound|END_ENTITY	Osteopontin and MMP9 : Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate_Cancer Cells .
22488688	0	Osteopontin	0,11	SOX9	44,48	Osteopontin	SOX9	6696	6662	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver_fibrosis in humans .
22276228	0	Osteopontin	16,27	SPP1	34,38	Osteopontin	SPP1	6696	6696	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Polymorphism in Osteopontin Gene -LRB- SPP1 -RRB- Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population .
24718314	0	Osteopontin	0,11	TGF-b2	26,32	Osteopontin	TGF-b2	6696	7042	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Osteopontin is induced by TGF-b2 and regulates metabolic cell activity in cultured human optic nerve head astrocytes .
16237095	0	Osteopontin	0,11	Th1	51,54	Osteopontin	Th1	20750(Tax:10090)	57314(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|responses responses|amod|END_ENTITY	Osteopontin is not required for the development of Th1 responses and viral immunity .
19850036	0	Osteopontin	0,11	beta-catenin	20,32	Osteopontin	beta-catenin	6696	1499	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Osteopontin induces beta-catenin signaling through activation of Akt in prostate_cancer cells .
23074199	0	Osteopontin	0,11	heme_oxygenase-1	22,38	Osteopontin	heme oxygenase-1	6696	15368(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Osteopontin increases heme_oxygenase-1 expression and subsequently induces cell migration and invasion in glioma cells .
14704150	0	Osteopontin	0,11	urokinase-type_plasminogen_activator	47,83	Osteopontin	urokinase-type plasminogen activator	6696	5328	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Osteopontin induces AP-1-mediated secretion of urokinase-type_plasminogen_activator through c-Src-dependent epidermal_growth_factor_receptor transactivation in breast_cancer cells .
26824421	0	Osteopontin	0,11	vimentin	102,110	Osteopontin	vimentin	6696	7431	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Osteopontin promotes epithelial-mesenchymal transition of hepatocellular_carcinoma through regulating vimentin .
16155791	0	Osteoprotegerin	0,15	OPG	17,20	Osteoprotegerin	OPG	4982	4982	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- expression by breast_cancer cells in vitro and breast_tumours in vivo -- a role in tumour cell survival ?
21748518	0	Osteoprotegerin	0,15	RANK	44,48	Osteoprotegerin	RANK	4982	8792	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- and related proteins -LRB- RANK , RANKL and TRAIL -RRB- in thyroid_disease .
15124262	0	Osteoprotegerin	0,15	RANK-L	22,28	Osteoprotegerin	RANK-L	4982	8600	Gene	Gene	START_ENTITY|dep|system system|amod|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- / RANK-L system in juvenile_idiopathic_arthritis : is there a potential modulating role for OPG/RANK-L in bone_injury ?
11426018	0	Osteoprotegerin	0,15	RANKL	72,77	Osteoprotegerin	RANKL	4982	8600	Gene	Gene	activator|compound|START_ENTITY ligand|nsubj|activator ligand|ccomp|regulate regulate|nsubj|END_ENTITY	Osteoprotegerin and receptor activator of nuclear factor kappaB ligand -LRB- RANKL -RRB- regulate osteoclast formation by cells in the human rheumatoid_arthritic_joint .
12408468	0	Osteoprotegerin	0,15	RANKL	72,77	Osteoprotegerin	RANKL	4982	8600	Gene	Gene	activator|compound|START_ENTITY ligand|nsubj|activator ligand|dep|END_ENTITY	Osteoprotegerin and receptor activator of nuclear factor-kappaB ligand -LRB- RANKL -RRB- in the serum of healthy adults .
21748518	0	Osteoprotegerin	0,15	RANKL	50,55	Osteoprotegerin	RANKL	4982	8600	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|RANK RANK|dep|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- and related proteins -LRB- RANK , RANKL and TRAIL -RRB- in thyroid_disease .
26629528	0	Osteoprotegerin	0,15	RANKL	87,92	Osteoprotegerin	RANKL	4982	8600	Gene	Gene	START_ENTITY|appos|Inhibitor Inhibitor|nmod|Activator Activator|nmod|Ligand Ligand|appos|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- , The Endogenous Inhibitor of Receptor Activator of NF-kB Ligand -LRB- RANKL -RRB- , is Dysregulated in BRCA Mutation Carriers .
26909278	0	Osteoprotegerin	0,15	RANKL	126,131	Osteoprotegerin	RANKL	4982	8600	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|inhibiting inhibiting|dobj|END_ENTITY	Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing 's _ sarcoma by inhibiting RANKL .
27028343	0	Osteoprotegerin	0,15	RANKL	17,22	Osteoprotegerin	RANKL	4982	8600	Gene	Gene	ADMA|compound|START_ENTITY ADMA|appos|END_ENTITY	Osteoprotegerin , RANKL , ADMA , and Fetuin-A serum levels in children with type_I_diabetes_mellitus .
26561998	0	Osteoprotegerin	103,118	Receptor_Activator_of_Nuclear_Factor-kb_Ligand	56,102	Osteoprotegerin	Receptor Activator of Nuclear Factor-kb Ligand	4982	8600	Gene	Gene	System|compound|START_ENTITY Effects|dep|System Effects|nmod|END_ENTITY	The Effects of Initial Periodontal Therapy on the Serum Receptor_Activator_of_Nuclear_Factor-kb_Ligand / Osteoprotegerin System in Patients With Type_2_Diabetes_Mellitus and Periodontitis .
15270863	0	Osteoprotegerin	0,15	TRAIL	120,125	Osteoprotegerin	TRAIL	4982	8743	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|receptor receptor|nmod|tumour_necrosis_factor-related_apoptosis-inducing_ligand tumour_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- acts as an endogenous decoy receptor in tumour_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis of fibroblast-like synovial cells .
16413220	0	Osteoprotegerin	0,15	TRAIL	90,95	Osteoprotegerin	TRAIL	4982	8743	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|ligand ligand|appos|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- binds with tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- : suppression of TRAIL-induced apoptosis in ameloblastomas .
18338379	0	Osteoprotegerin	0,15	TRAIL	71,76	Osteoprotegerin	TRAIL	4982	8743	Gene	Gene	decreases|nsubj|START_ENTITY decreases|advcl|inhibiting inhibiting|dobj|pathway pathway|amod|END_ENTITY	Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway .
25636966	0	Osteoprotegerin	12,27	TRAIL	36,41	Osteoprotegerin	TRAIL	4982	8743	Gene	Gene	Binding|compound|START_ENTITY Binding|compound|END_ENTITY	Variants of Osteoprotegerin Lacking TRAIL Binding for Therapeutic Bone Remodeling in Osteolytic_Malignancies .
9603945	0	Osteoprotegerin	0,15	TRAIL	55,60	Osteoprotegerin	TRAIL	4982	8743	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL .
26034511	0	Osteoprotegerin	0,15	insulin	31,38	Osteoprotegerin	insulin	4982	3630	Gene	Gene	START_ENTITY|nmod|relation relation|nmod|resistance resistance|compound|END_ENTITY	Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal_obesity .
19602124	0	Osteoprotegerin	0,15	osteopontin	24,35	Osteoprotegerin	osteopontin	4982	6696	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Osteoprotegerin induces osteopontin via syndecan-1_and_phosphoinositol_3-kinase / Akt in human periodontal ligament cells .
11306358	0	Osteoprotegerin	0,15	prostate_cancer	46,61	Osteoprotegerin	osteoprotegerin	4982	4982	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Osteoprotegerin and rank_ligand expression in prostate_cancer .
17182555	0	Osteoprotegerin	0,15	receptor_activator_of_NF-kappaB_ligand	43,81	Osteoprotegerin	receptor activator of NF-kappaB ligand	18383(Tax:10090)	21943(Tax:10090)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|level level|nmod|END_ENTITY	Osteoprotegerin reduces the serum level of receptor_activator_of_NF-kappaB_ligand derived from osteoblasts .
17706953	0	Osteoprotegerin	0,15	tumor_necrosis_factor-alpha	75,102	Osteoprotegerin	tumor necrosis factor-alpha	4982	7124	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|END_ENTITY	Osteoprotegerin upregulates endothelial cell adhesion molecule response to tumor_necrosis_factor-alpha associated with induction of angiopoietin-2 .
18056716	0	Osterix	14,21	BMP-2	0,5	Osterix	BMP-2	170574(Tax:10090)	12156(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38 .
18703512	0	Osterix	15,22	BMP2	0,4	Osterix	BMP2	170574(Tax:10090)	12156(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation .
23159876	0	Osterix	0,7	Col1a1	16,22	Osterix	Col1a1	170574(Tax:10090)	12842(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions .
22056560	0	Osterix	0,7	Erk1/2	24,30	Osterix	Erk1/2	121340	5595;5594	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Osterix is regulated by Erk1/2 during osteoblast differentiation .
18703512	0	Osterix	15,22	Msx2	31,35	Osterix	Msx2	170574(Tax:10090)	17702(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation .
25463757	0	Osterix	59,66	Pin1	17,21	Osterix	Pin1	121340	5300	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix .
17303075	0	Osterix	27,34	RNA_helicase_A	59,73	Osterix	RNA helicase A	121340	1660	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The transcriptional factor Osterix directly interacts with RNA_helicase_A .
17352693	0	Osterix	27,34	Runx3	0,5	Osterix	Runx3	170574(Tax:10090)	12399(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Runx3 negatively regulates Osterix expression in dental pulp cells .
15474293	0	Osterix	84,91	SP7	93,96	Osterix	SP7	121340	121340	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , structure , expression , and chromosomal localization of the human Osterix -LRB- SP7 -RRB- gene .
21828043	0	Osterix	41,48	Satb2	83,88	Osterix	Satb2	170574(Tax:10090)	212712(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- is an upstream regulator of Satb2 during bone formation .
26801561	0	Osterix	15,22	TIEG1	0,5	Osterix	TIEG1	170574(Tax:10090)	21847(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	TIEG1 enhances Osterix expression and mediates its induction by TGFb and BMP2 in osteoblasts .
22110141	0	Osterix	116,123	VEGF	66,70	Osterix	VEGF	170574(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- by osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- in osteoblasts .
22110141	0	Osterix	116,123	Vascular_Endothelial_Growth_Factor	30,64	Osterix	Vascular Endothelial Growth Factor	170574(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- by osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- in osteoblasts .
22869368	0	Osterix	0,7	matrix_metalloproteinase_13	81,108	Osterix	matrix metalloproteinase 13	170574(Tax:10090)	17386(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Osterix regulates calcification and degradation of chondrogenic matrices through matrix_metalloproteinase_13 -LRB- MMP13 -RRB- expression in association with transcription factor Runx2 during endochondral ossification .
18056716	0	Osterix	14,21	p38	90,93	Osterix	p38	170574(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38 .
22028889	0	Osterix	41,48	vitamin_D_receptor	59,77	Osterix	vitamin D receptor	170574(Tax:10090)	22337(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Osteoblast-specific transcription factor Osterix increases vitamin_D_receptor gene expression in osteoblasts .
16525474	0	Ostm1	15,20	ClC-7	0,5	Ostm1	ClC-7	14628(Tax:10090)	26373(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function .
24159188	0	Ostm1	84,89	ClC-7	78,83	Ostm1	ClC-7	518522(Tax:9913)	513545(Tax:9913)	Gene	Gene	START_ENTITY|dep|+ +|dep|END_ENTITY	A missense mutation accelerating the gating of the lysosomal Cl - / H + - exchanger ClC-7 / Ostm1 causes osteopetrosis with gingival_hamartomas in cattle .
19505977	0	Osx	41,44	parathyroid_hormone	57,76	Osx	parathyroid hormone	300260(Tax:10116)	24694(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Regulation of osterix -LRB- Osx , Sp7 -RRB- and the Osx promoter by parathyroid_hormone in osteoblasts .
22613993	0	Otoferlin	48,57	Ergic2	0,6	Otoferlin	Ergic2	83762(Tax:10090)	67456(Tax:10090)	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Ergic2 , a brain specific interacting partner of Otoferlin .
19417007	0	Otoferlin	0,9	myosin_VI	25,34	Otoferlin	myosin VI	83762(Tax:10090)	17920(Tax:10090)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Otoferlin interacts with myosin_VI : implications for maintenance of the basolateral synaptic structure of the inner hair cell .
22124327	0	Otubain_1	81,90	p53	23,26	Otubain 1	p53	55611	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|stability stability|compound|END_ENTITY	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain_1 .
9077465	0	Otx1	0,4	Otx2	28,32	Otx1	Otx2	18423(Tax:10090)	18424(Tax:10090)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain .
8613727	0	Otx2	37,41	Fibroblast_growth_factor_2	0,26	Otx2	Fibroblast growth factor 2	5015	2247	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Fibroblast_growth_factor_2 increases Otx2 expression in precursor cells from mammalian telencephalon .
10330495	0	Otx2	24,28	Gbx2	30,34	Otx2	Gbx2	395191(Tax:9031)	395950(Tax:9031)	Gene	Gene	Fgf8|compound|START_ENTITY Fgf8|dep|END_ENTITY	Comparative analysis of Otx2 , Gbx2 , Pax2 , Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain .
10490024	0	Otx2	33,37	Gbx2	11,15	Otx2	Gbx2	18424(Tax:10090)	14472(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer .
11850185	0	Otx2	20,24	Gbx2	0,4	Otx2	Gbx2	399342(Tax:8355)	399181(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Gbx2 interacts with Otx2 and patterns the anterior-posterior axis during gastrulation in Xenopus .
22566684	0	Otx2	24,28	Gbx2	0,4	Otx2	Gbx2	18424(Tax:10090)	14472(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY restricts|dobj|expression restricts|nsubj|END_ENTITY	Gbx2 directly restricts Otx2 expression to forebrain and midbrain , competing with class III POU factors .
26160903	0	Otx2	0,4	N-myc	20,25	Otx2	N-myc	5015	4613	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea .
9077465	0	Otx2	28,32	Otx1	0,4	Otx2	Otx1	18424(Tax:10090)	18423(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain .
10330495	0	Otx2	24,28	Pax2	36,40	Otx2	Pax2	395191(Tax:9031)	395574(Tax:9031)	Gene	Gene	Fgf8|compound|START_ENTITY Fgf8|dep|END_ENTITY	Comparative analysis of Otx2 , Gbx2 , Pax2 , Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain .
19736326	0	Otx2	65,69	Tle4	45,49	Otx2	Tle4	395191(Tax:9031)	374080(Tax:9031)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|nmod|binding	Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer .
17332747	0	Otx2	25,29	YY1	11,14	Otx2	YY1	18424(Tax:10090)	22632(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Acetylated YY1 regulates Otx2 expression in anterior_neuroectoderm at two cis-sites 90 kb apart .
24142153	0	Ovalbumin	0,9	GM-CSF	33,39	Ovalbumin	GM-CSF	282665(Tax:10090)	12981(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Ovalbumin enhances YKL-40 , IL-5 , GM-CSF , and eotaxin expression simultaneously in primarily cultured mouse tracheal epithelial cells .
11293507	0	Ovalbumin	0,9	ovalbumin	57,66	Ovalbumin	ovalbumin	282665(Tax:10090)	282665(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Ovalbumin fused with diphtheria toxin protects mice from ovalbumin induced anaphylactic shock .
17344477	0	Oxa1	0,4	Atp9	29,33	Oxa1	Atp9	856898(Tax:4932)	854584(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Oxa1 directly interacts with Atp9 and mediates its assembly into the mitochondrial F1Fo-ATP synthase complex .
11148275	0	Oxa1p	72,77	AtOXA1	30,36	Oxa1p	AtOXA1	856898(Tax:4932)	836325(Tax:3702)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Mitochondrial localization of AtOXA1 , an arabidopsis homologue of yeast Oxa1p involved in the insertion and assembly of protein complexes in mitochondrial inner membrane .
25575590	0	Oxaloacetate_Decarboxylase	61,87	FAH_Domain-containing_Protein_1	18,49	Oxaloacetate Decarboxylase	FAH Domain-containing Protein 1	81889	81889	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of FAH_Domain-containing_Protein_1 -LRB- FAHD1 -RRB- as Oxaloacetate_Decarboxylase .
25657046	0	OxeR1	0,5	angiotensin_II	16,30	OxeR1	angiotensin II	165140	183	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	OxeR1 regulates angiotensin_II and cAMP-stimulated steroid production in human H295R adrenocortical cells .
19549845	0	Oxidoreductase	0,14	Ost3p	62,67	Oxidoreductase	Ost3p	855266(Tax:4932)	854252(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency .
23404117	0	Oxr1	52,56	oxidation_resistance_1	28,50	Oxr1	oxidation resistance 1	170719(Tax:10090)	170719(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MicroRNA-200b downregulates oxidation_resistance_1 -LRB- Oxr1 -RRB- expression in the retina of type 1 diabetes model .
22434086	0	Oxt	85,88	oxytocin	75,83	Oxt	oxytocin	18429(Tax:10090)	18429(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	The ERb ligand 5a-androstane , 3b,17b-diol -LRB- 3b-diol -RRB- regulates hypothalamic oxytocin -LRB- Oxt -RRB- gene expression .
22967062	0	Oxtr	50,54	oxytocin_receptor	26,43	Oxtr	oxytocin receptor	18430(Tax:10090)	18430(Tax:10090)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Mice heterozygous for the oxytocin_receptor gene -LRB- Oxtr -LRB- + / - -RRB- -RRB- show impaired_social_behaviour but not increased_aggression or cognitive inflexibility : evidence of a selective haploinsufficiency gene effect .
20303388	0	Oxytocin	0,8	OXTR	19,23	Oxytocin	OXTR	5020	5021	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Oxytocin receptor -LRB- OXTR -RRB- does not play a major role in the aetiology of autism : genetic and molecular studies .
14967939	0	Oxytocin	0,8	insulin-like_growth_factor-I	34,62	Oxytocin	insulin-like growth factor-I	5020	3479	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Oxytocin mediates some effects of insulin-like_growth_factor-I on porcine ovarian follicles .
26121678	0	Oxytocin_Receptor	15,32	OXTR	39,43	Oxytocin Receptor	OXTR	5021	5021	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of Oxytocin_Receptor Gene -LRB- OXTR -RRB- rs53576 Polymorphism with Sociality : A Meta-Analysis .
21896752	0	Oxytocin_receptor	0,17	OXTR	24,28	Oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Oxytocin_receptor gene -LRB- OXTR -RRB- is related to psychological resources .
8592922	0	P-105_and_p-120	61,76	PCNA	55,59	P-105 and p-120	PCNA	4790;4839	5111	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	-LSB- Ag-NORs , nucleus-nucleolus-associated antigens -LRB- Ki67 , PCNA , P-105_and_p-120 -RRB- : prognostic markers of meningioma recurrence -RSB- .
9378810	0	P-170	20,25	mdr-1	6,11	P-170	mdr-1	18704(Tax:10090)	18669(Tax:10090)	Gene	Gene	antibody|compound|START_ENTITY antibody|amod|END_ENTITY	A new mdr-1 encoded P-170 specific monoclonal antibody : -LRB- 6/1C -RRB- on paraffin wax embedded tissue without pretreatment of sections .
3741479	0	P-450	35,40	estrogen_synthetase	42,61	P-450	estrogen synthetase	1555	1588	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of aromatase cytochrome P-450 -LRB- estrogen_synthetase -RRB- by derivatives of alpha-naphthoflavone .
1346492	0	P-450C18	101,109	CYP11B2	116,123	P-450C18	CYP11B2	1585	1585	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Congenitally defective aldosterone biosynthesis in humans : the involvement of point mutations of the P-450C18 gene -LRB- CYP11B2 -RRB- in CMO_II_deficient patients .
8439335	0	P-450C18	79,87	CYP11B2	94,101	P-450C18	CYP11B2	1585	1585	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Congenitally defective aldosterone biosynthesis in humans : inactivation of the P-450C18 gene -LRB- CYP11B2 -RRB- due to nucleotide deletion in CMO_I_deficient patients .
2162843	0	P-450C21	50,58	CYP21B	42,48	P-450C21	CYP21B	281741(Tax:9913)	1589	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	cAMP-dependent transcription of the human CYP21B -LRB- P-450C21 -RRB- gene requires a cis-regulatory element distinct from the consensus cAMP-regulatory element .
1971562	0	P-450c	8,14	TACE	80,84	P-450c	TACE	24296(Tax:10116)	57027(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of P-450c in the formation of a reactive intermediate of chlorotrianisene -LRB- TACE -RRB- by hepatic microsomes from methylcholanthrene-treated rats .
3418515	0	P-450j	59,65	cytochrome_P-450	22,38	P-450j	cytochrome P-450	25086(Tax:10116)	25251(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY induction|dep|role induction|nmod|END_ENTITY	Pyridine induction of cytochrome_P-450 in the rat : role of P-450j -LRB- alcohol-inducible form -RRB- in pyridine_N-oxidation .
25594233	0	P-Glycoprotein	34,48	ATPase	90,96	P-Glycoprotein	ATPase	5243	1769	Gene	Gene	Function|compound|START_ENTITY Function|nmod|Activity Activity|compound|END_ENTITY	Demethoxycurcumin Modulates Human P-Glycoprotein Function via Uncompetitive Inhibition of ATPase Hydrolysis Activity .
25522789	0	P-Glycoprotein	38,52	BCRP	98,102	P-Glycoprotein	BCRP	5243	644079	Gene	Gene	Knockout|nmod|START_ENTITY END_ENTITY|nsubj|Knockout	Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type , Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases .
25522789	0	P-Glycoprotein	73,87	BCRP	98,102	P-Glycoprotein	BCRP	5243	644079	Gene	Gene	P-Glycoprotein|nmod|START_ENTITY Knockout|nmod|P-Glycoprotein END_ENTITY|nsubj|Knockout	Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type , Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases .
25932627	0	P-Glycoprotein	16,30	MDR1	118,122	P-Glycoprotein	MDR1	67078(Tax:10090)	5243	Gene	Gene	P-gp|amod|START_ENTITY Validation|nmod|P-gp Humanized|nsubj|Validation Humanized|nmod|Quantification Quantification|nmod|END_ENTITY	Validation of a P-Glycoprotein -LRB- P-gp -RRB- Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1 , Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport .
14501258	0	P-Glycoprotein	0,14	mdr1a	149,154	P-Glycoprotein	mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	efflux|amod|START_ENTITY reduces|nsubj|efflux reduces|parataxis|study study|acl|using using|xcomp|END_ENTITY	P-Glycoprotein efflux reduces the brain concentration of the substance_P -LRB- NK1_receptor -RRB- antagonists SR140333 and GR205171 : a comparative study using mdr1a - / - and mdr1a + / + mice .
14501258	0	P-Glycoprotein	0,14	mdr1a	162,167	P-Glycoprotein	mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	efflux|amod|START_ENTITY reduces|nsubj|efflux reduces|parataxis|study study|acl|using using|xcomp|mdr1a mdr1a|dep|/ /|dep|+ +|amod|END_ENTITY	P-Glycoprotein efflux reduces the brain concentration of the substance_P -LRB- NK1_receptor -RRB- antagonists SR140333 and GR205171 : a comparative study using mdr1a - / - and mdr1a + / + mice .
20150869	0	P-LAP	60,65	Placental_Leucine_Aminopeptidase	26,58	P-LAP	Placental Leucine Aminopeptidase	4012	4012	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Alteration of circulating Placental_Leucine_Aminopeptidase -LRB- P-LAP -RRB- activity in preeclampsia .
15491750	0	P-LAP	34,39	Placental_leucine_aminopeptidase	0,32	P-LAP	Placental leucine aminopeptidase	4012	4012	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Placental_leucine_aminopeptidase -LRB- P-LAP -RRB- expression is associated with chemosensitivity in human endometrial_carcinoma .
16187279	0	P-LAP	51,56	placental_leucine_aminopeptidase	17,49	P-LAP	placental leucine aminopeptidase	4012	4012	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for placental_leucine_aminopeptidase -LRB- P-LAP -RRB- as a determinant of chemoresistance in endometrial_carcinoma cells .
6343531	0	P-LAP	92,97	placental_leucine_aminopeptidase	58,90	P-LAP	placental leucine aminopeptidase	4012	4012	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Changes in plasma renin activity -LRB- PRA -RRB- , angiotensin_I and placental_leucine_aminopeptidase -LRB- P-LAP -RRB- activity during normal pregnancy .
8926015	0	P-LAP	85,90	placental_leucine_aminopeptidase	51,83	P-LAP	placental leucine aminopeptidase	4012	4012	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Relationship between the changes in maternal serum placental_leucine_aminopeptidase -LRB- P-LAP -RRB- activity and umbilical artery waveforms in normal pregnancy .
7708713	0	P-Lim	0,5	Pit-1	109,114	P-Lim	Pit-1	16871(Tax:10090)	18736(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	P-Lim , a LIM homeodomain factor , is expressed during pituitary organ and cell commitment and synergizes with Pit-1 .
21172654	0	P-Rex1	30,36	ErbB	65,69	P-Rex1	ErbB	57580	1956	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast_cancer .
23382862	0	P-Rex1	0,6	PDGFRb	23,29	P-Rex1	PDGFRb	57580	5159	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	P-Rex1 cooperates with PDGFRb to drive cellular migration in 3D microenvironments .
18502673	0	P-Rex1	30,36	Rac1	70,74	P-Rex1	Rac1	277360(Tax:10090)	19353(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Lack of a significant role of P-Rex1 , a major regulator of macrophage Rac1 activation and chemotaxis , in atherogenesis .
26112412	0	P-Rex1	117,123	Rac1	159,163	P-Rex2	Rac1	80243	5879	Gene	Gene	Substrate|dep|START_ENTITY Substrate|acl:relcl|Reveals Reveals|dobj|Basis Basis|nmod|Activation Activation|compound|END_ENTITY	The Phosphatidylinositol -LRB- 3,4,5 -RRB- - trisphosphate-dependent Rac Exchanger 1 : Ras-related C3 Botulinum Toxin Substrate 1 -LRB- P-Rex1 : Rac1 -RRB- Complex Reveals the Basis of Rac1 Activation in Breast_Cancer Cells .
16243036	0	P-Rex1	0,6	Rac2	20,24	P-Rex1	Rac2	277360(Tax:10090)	19354(Tax:10090)	Gene	Gene	factor|nsubj|START_ENTITY factor|amod|END_ENTITY	P-Rex1 is a primary Rac2 guanine_nucleotide exchange factor in mouse neutrophils .
24659802	0	P-Rex1	0,6	RhoG	26,30	P-Rex1	RhoG	277360(Tax:10090)	56212(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils .
17565979	0	P-Rex1	0,6	mammalian_target_of_rapamycin	13,42	P-Rex1	mammalian target of rapamycin	57580	2475	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	P-Rex1 links mammalian_target_of_rapamycin signaling to Rac activation and cell migration .
26102172	0	P-Selectin	0,10	CD62P	12,17	P-Selectin	CD62P	6403	6403	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	P-Selectin -LRB- CD62P -RRB- Expression in Liver Tissue of Biliary_Atresia : A New Perspective in Etiopathogenesis .
10770806	0	P-Selectin	0,10	PSGL-1	34,40	P-Selectin	PSGL-1	6403	6404	Gene	Gene	glycoprotein|amod|START_ENTITY ligand|nsubj|glycoprotein ligand|ccomp|expressed expressed|nsubjpass|1 1|appos|END_ENTITY	P-Selectin glycoprotein ligand 1 -LRB- PSGL-1 -RRB- is expressed on platelets and can mediate platelet-endothelial interactions in vivo .
11104809	0	P-Selectin_glycoprotein_ligand_1	0,32	E-selectin	72,82	P-Selectin glycoprotein ligand 1	E-selectin	20345(Tax:10090)	20339(Tax:10090)	Gene	Gene	physiological|nsubj|START_ENTITY physiological|acl|ligand ligand|nmod|END_ENTITY	P-Selectin_glycoprotein_ligand_1 -LRB- PSGL-1 -RRB- is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration .
17292359	0	P-cadherin	23,33	beta-Catenin	0,12	P-cadherin	beta-Catenin	12560(Tax:10090)	12387(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells .
21317933	0	P-cadherin	0,10	insulin-like_growth_factor-1_receptor	27,64	P-cadherin	insulin-like growth factor-1 receptor	12560(Tax:10090)	16001(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|END_ENTITY	P-cadherin cooperates with insulin-like_growth_factor-1_receptor to promote metastatic signaling of gonadotropin-releasing_hormone in ovarian_cancer via p120_catenin .
18827354	0	P-glycoprotein	51,65	ABCA5	107,112	P-glycoprotein	ABCA5	5243	23461	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Effect of tacrolimus on activity and expression of P-glycoprotein and ATP-binding cassette transporter A5 -LRB- ABCA5 -RRB- proteins in hematoencephalic barrier cells .
15637529	0	P-glycoprotein	111,125	ABCB1	104,109	P-glycoprotein	ABCB1	5243	5243	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Hepatic technetium_Tc 99m-labeled sestamibi elimination rate and ABCB1 -LRB- MDR1 -RRB- genotype as indicators of ABCB1 -LRB- P-glycoprotein -RRB- activity in patients with cancer .
17933684	0	P-glycoprotein	60,74	ABCB1	76,81	P-glycoprotein	ABCB1	67078(Tax:10090)	18669(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Drug-drug interactions affected by the transporter protein , P-glycoprotein -LRB- ABCB1 , MDR1 -RRB- I. Preclinical aspects .
19846941	0	P-glycoprotein	73,87	ABCB1	89,94	P-glycoprotein	ABCB1	5243	18669(Tax:10090)	Gene	Gene	balsamina|nmod|START_ENTITY triterpenoids|nmod|balsamina Evaluation|nmod|triterpenoids Evaluation|appos|END_ENTITY	Evaluation of cucurbitane-type triterpenoids from Momordica balsamina on P-glycoprotein -LRB- ABCB1 -RRB- by flow cytometry and real-time fluorometry .
21341745	0	P-glycoprotein	32,46	ABCB1	48,53	P-glycoprotein	ABCB1	5243	5243	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	A novel approach for predicting P-glycoprotein -LRB- ABCB1 -RRB- inhibition using molecular interaction fields .
21366702	0	P-glycoprotein	0,14	ABCB1	16,21	P-glycoprotein	ABCB1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	P-glycoprotein -LRB- ABCB1 -RRB- expression in human skin is mainly restricted to dermal components .
21999196	0	P-glycoprotein	20,34	ABCB1	13,18	P-glycoprotein	ABCB1	5243	5243	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of ABCB1 -LRB- P-glycoprotein -RRB- haplotypes on nortriptyline pharmacokinetics and nortriptyline-induced postural_hypotension in healthy volunteers .
25036383	0	P-glycoprotein	45,59	ABCB1	61,66	P-glycoprotein	ABCB1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interrogation of multidrug resistance -LRB- MDR1 -RRB- P-glycoprotein -LRB- ABCB1 -RRB- expression in human pancreatic_carcinoma cells : correlation of 99mTc-Sestamibi uptake with western blot analysis .
15845415	0	P-glycoprotein	39,53	ABCG2	77,82	P-glycoprotein	ABCG2	5243	9429	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Multidrug resistance proteins : role of P-glycoprotein , MRP1 , MRP2 , and BCRP -LRB- ABCG2 -RRB- in tissue defense .
22123128	0	P-glycoprotein	52,66	ABCG2	125,130	P-glycoprotein	ABCG2	5243	9429	Gene	Gene	START_ENTITY|appos|BCRP BCRP|dep|END_ENTITY	Functional significance of genetic polymorphisms in P-glycoprotein -LRB- MDR1 , ABCB1 -RRB- and breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- .
10727524	0	P-glycoprotein	98,112	ATPase	70,76	P-glycoprotein	ATPase	5243	1769	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|activity activity|amod|END_ENTITY	Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe -LRB- 335 -RRB- .
10806188	0	P-glycoprotein	41,55	ATPase	16,22	P-glycoprotein	ATPase	5243	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites .
11598005	0	P-glycoprotein	42,56	ATPase	78,84	P-glycoprotein	ATPase	5243	1769	Gene	Gene	domains|nmod|START_ENTITY domains|nmod|cycle cycle|compound|END_ENTITY	Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle .
11926837	0	P-glycoprotein	95,109	ATPase	40,46	P-glycoprotein	ATPase	5243	1769	Gene	Gene	site|nmod|START_ENTITY places|dobj|site places|nsubj|Proximity Proximity|nmod|sites sites|amod|bound bound|dep|Hoechst_33342 Hoechst_33342|nmod|END_ENTITY	Proximity of bound Hoechst_33342 to the ATPase catalytic sites places the drug binding site of P-glycoprotein within the cytoplasmic membrane leaflet .
12055198	0	P-glycoprotein	55,69	ATPase	84,90	P-glycoprotein	ATPase	5243	1769	Gene	Gene	Region|nmod|START_ENTITY Cleavage|nmod|Region Modulates|nsubj|Cleavage Modulates|dobj|Function Function|compound|END_ENTITY	Proteolytic Cleavage of the Linker Region of the Human P-glycoprotein Modulates Its ATPase Function .
17367162	0	P-glycoprotein	27,41	ATPase	90,96	P-glycoprotein	ATPase	5243	1769	Gene	Gene	efflux|amod|START_ENTITY inhibition|nmod|efflux Mechanism|nmod|inhibition Mechanism|dep|influence influence|nmod|activity activity|amod|END_ENTITY	Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin_E_TPGS : influence on ATPase activity and membrane fluidity .
18937360	0	P-glycoprotein	35,49	ATPase	94,100	P-glycoprotein	ATPase	5243	1769	Gene	Gene	activation|nmod|START_ENTITY activation|dep|effects effects|nmod|activities activities|compound|END_ENTITY	Cholesterol-mediated activation of P-glycoprotein : distinct effects on basal and drug-induced ATPase activities .
20004641	0	P-glycoprotein	0,14	ATPase	80,86	P-glycoprotein	ATPase	5243	1769	Gene	Gene	transport|amod|START_ENTITY assessed|nsubj|transport assessed|advcl|comparing comparing|dobj|activity activity|compound|END_ENTITY	P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity .
23720244	0	P-glycoprotein	50,64	ATPase	40,46	P-glycoprotein	ATPase	5243	1769	Gene	Gene	cells|amod|START_ENTITY Interaction|nmod|cells Interaction|nmod|END_ENTITY	Interaction of CJY , an isoflavone , with ATPase of P-glycoprotein in doxorubicin-resistant human myelogenous_leukemia -LRB- K562/DOX -RRB- cells .
24523403	0	P-glycoprotein	64,78	ATPase	106,112	P-glycoprotein	ATPase	5243	1769	Gene	Gene	START_ENTITY|acl:relcl|triggers triggers|dobj|switch switch|compound|END_ENTITY	Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch .
7629050	0	P-glycoprotein	45,59	ATPase	16,22	P-glycoprotein	ATPase	5243	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Drug-stimulated ATPase activity of the human P-glycoprotein .
7665554	0	P-glycoprotein	28,42	ATPase	169,175	P-glycoprotein	ATPase	5243	1769	Gene	Gene	mutants|amod|START_ENTITY purification|nmod|mutants expressed|nsubj|purification expressed|nmod|chromatography chromatography|nmod|activities activities|compound|END_ENTITY	Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities .
7907331	0	P-glycoprotein	96,110	ATPase	34,40	P-glycoprotein	ATPase	5243	1769	Gene	Gene	half|nmod|START_ENTITY co-expression|nmod|half co-expression|compound|END_ENTITY	Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides .
9016791	0	P-glycoprotein	35,49	ATPase	25,31	P-glycoprotein	ATPase	5243	1769	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Functional modulation of ATPase of P-glycoprotein by C219 , a monoclonal antibody against P-glycoprotein .
9016791	0	P-glycoprotein	89,103	ATPase	25,31	P-glycoprotein	ATPase	5243	1769	Gene	Gene	antibody|nmod|START_ENTITY C219|appos|antibody modulation|nmod|C219 modulation|nmod|END_ENTITY	Functional modulation of ATPase of P-glycoprotein by C219 , a monoclonal antibody against P-glycoprotein .
9528676	0	P-glycoprotein	54,68	ATPase	35,41	P-glycoprotein	ATPase	5243	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form .
9746361	0	P-glycoprotein	40,54	ATPase	4,10	P-glycoprotein	ATPase	5243	1769	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	The ATPase and ATP-binding functions of P-glycoprotein -- modulation by interaction with defined phospholipids .
9914470	0	P-glycoprotein	80,94	ATPase	95,101	P-glycoprotein	ATPase	5243	1769	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Membrane fluidization by ether , other anesthetics , and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells .
24239898	0	P-glycoprotein	0,14	Anxa2	31,36	P-glycoprotein	Anxa2	5243	302	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	P-glycoprotein associates with Anxa2 and promotes invasion in multidrug resistant breast_cancer cells .
22115371	0	P-glycoprotein	12,26	BCRP	65,69	P-glycoprotein	BCRP	5243	9429	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of P-glycoprotein and breast_cancer_resistance_protein -LRB- BCRP -RRB- in bacterial attachment to human gastrointestinal cells .
24295377	0	P-glycoprotein	59,73	BCRP	86,90	P-glycoprotein	BCRP	5243	9429	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Tivozanib reverses multidrug resistance mediated by ABCB1 -LRB- P-glycoprotein -RRB- and ABCG2 -LRB- BCRP -RRB- .
12031911	0	P-glycoprotein	51,65	CD34	78,82	P-glycoprotein	CD34	5243	947	Gene	Gene	activity|amod|START_ENTITY activity|nmod|cells cells|nummod|END_ENTITY	Influence of functional MDR1 gene polymorphisms on P-glycoprotein activity in CD34 + hematopoietic stem cells .
12100168	0	P-glycoprotein	45,59	CD34	63,67	P-glycoprotein	CD34	5243	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Reduced function of the multidrug resistance P-glycoprotein in CD34 + cells of patients with aplastic_anaemia .
8562416	0	P-glycoprotein	11,25	CD34	112,116	P-glycoprotein	CD34	5243	947	Gene	Gene	Studies|nmod|START_ENTITY Studies|dep|expression expression|nmod|antigen antigen|compound|END_ENTITY	Studies of P-glycoprotein in chronic myelogenous_leukaemia patients : expression , activity and correlations with CD34 antigen .
12714803	0	P-glycoprotein	52,66	CD4	121,124	P-glycoprotein	CD4	5243	920	Gene	Gene	function|amod|START_ENTITY protease|nmod|function protease|nmod|variants variants|nmod|line line|compound|END_ENTITY	Differential effect of HIV-1 protease inhibitors on P-glycoprotein function in multidrug-resistant variants of the human CD4 + T_lymphoblastoid_CEM cell line .
14525546	0	P-glycoprotein	81,95	CD4	105,108	P-glycoprotein	CD4	5243	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Saquinavir induces stable and functional expression of the multidrug transporter P-glycoprotein in human CD4 T-lymphoblastoid CEMrev cells .
15201669	0	P-glycoprotein	0,14	CD4	40,43	P-glycoprotein	CD4	5243	920	Gene	Gene	activity|amod|START_ENTITY decreased|nsubjpass|activity decreased|nmod|+ +|compound|END_ENTITY	P-glycoprotein activity is decreased in CD4 + but not CD8 + lung allograft-infiltrating T cells during acute cellular rejection .
17890284	0	P-glycoprotein	14,28	CD4	141,144	P-glycoprotein	CD4	5243	920	Gene	Gene	proteins|amod|START_ENTITY Inhibition|nmod|proteins modulates|nsubj|Inhibition modulates|dobj|concentration concentration|nmod|lopinavir lopinavir|nmod|cells cells|compound|END_ENTITY	Inhibition of P-glycoprotein and multidrug resistance-associated proteins modulates the intracellular concentration of lopinavir in cultured CD4 T cells and primary human lymphocytes .
18451510	0	P-glycoprotein	0,14	CD4	45,48	P-glycoprotein	CD4	5243	920	Gene	Gene	functions|amod|START_ENTITY functions|nmod|cells cells|compound|END_ENTITY	P-glycoprotein functions in peripheral-blood CD4 + cells of patients with systemic_lupus_erythematosus .
19748977	0	P-glycoprotein	73,87	CD4	109,112	P-glycoprotein	CD4	5243	920	Gene	Gene	activity|amod|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Intracellular accumulation of efavirenz and nevirapine is independent of P-glycoprotein activity in cultured CD4 T cells and primary human lymphocytes .
11106230	0	P-glycoprotein	73,87	CD56	91,95	P-glycoprotein	CD56	5243	4684	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56 + lymphocytes after oral and intravenous administration .
11434506	0	P-glycoprotein	84,98	CD56	128,132	P-glycoprotein	CD56	5243	4684	Gene	Gene	rhodamine_123|amod|START_ENTITY efflux|nmod|rhodamine_123 associated|nmod|efflux associated|nmod|cells cells|nummod|END_ENTITY	The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine_123 from CD56 + natural killer cells .
15068897	0	P-glycoprotein	76,90	CD56	48,52	P-glycoprotein	CD56	5243	4684	Gene	Gene	overexpression|amod|START_ENTITY associated|nmod|overexpression associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the neural cell adhesion molecule CD56 is not associated with P-glycoprotein overexpression in core-binding factor acute myeloid_leukemia .
22782455	0	P-glycoprotein	37,51	CD56	72,76	P-glycoprotein	CD56	5243	4684	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Increased expression and function of P-glycoprotein in peripheral blood CD56 + cells is associated with the chemoresistance of non-small-cell_lung_cancer .
1351108	0	P-glycoprotein	63,77	CEA	181,184	P-glycoprotein	CEA	5243	1084	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Immunohistochemical detection of carcinoembryonic_antigen and P-glycoprotein in small_cell_lung_cancer at diagnosis and relapse , with special reference to the tissue expression of CEA and response to chemotherapy -RSB- .
26877779	0	P-glycoprotein	0,14	Chloride_Channel-3	104,122	P-glycoprotein	Chloride Channel-3	5243	1182	Gene	Gene	Formation|compound|START_ENTITY Formation|nmod|END_ENTITY	P-glycoprotein Mediates Postoperative Peritoneal Adhesion Formation by Enhancing Phosphorylation of the Chloride_Channel-3 .
19735720	0	P-glycoprotein	86,100	Cyclosporin_A	0,13	P-glycoprotein	Cyclosporin A	5243	1161	Gene	Gene	expression|amod|START_ENTITY imatinib_mesylate|nmod|expression sensitises|advcl|imatinib_mesylate sensitises|nsubj|END_ENTITY	Cyclosporin_A sensitises Bcr-Abl positive cells to imatinib_mesylate independently of P-glycoprotein expression .
21281239	0	P-glycoprotein	16,30	Ezrin	46,51	P-glycoprotein	Ezrin	5243	7430	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells .
9712351	0	P-glycoprotein	14,28	IL-4	0,4	P-glycoprotein	IL-4	5243	3565	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IL-4 inhibits P-glycoprotein in normal and malignant NK cells .
12138126	0	P-glycoprotein	21,35	MDR-1	14,19	P-glycoprotein	MDR-1	287115(Tax:10116)	24646(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MDR-1 -LRB- P-glycoprotein -RRB- by cyclooxygenase-2 .
8590843	0	P-glycoprotein	20,34	MDR-1	14,19	P-glycoprotein	MDR-1	5243	5243	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of MDR-1 / P-glycoprotein in childhood acute_megakaryoblastic_leukemia cells .
10384961	0	P-glycoprotein	68,82	MDR1	63,67	P-glycoprotein	MDR1	5243	5243	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Epitope mapping of the monoclonal antibody MM12 .10 to external MDR1 P-glycoprotein domain by synthetic peptide scanning and phage display technologies .
10581184	0	P-glycoprotein	61,75	MDR1	34,38	P-glycoprotein	MDR1	67078(Tax:10090)	18669(Tax:10090)	Gene	Gene	substrates|amod|START_ENTITY multidrug|nmod|substrates multidrug|dobj|leukemia leukemia|amod|resistant resistant|dep|END_ENTITY	Treatment of multidrug resistant -LRB- MDR1 -RRB- murine leukemia with P-glycoprotein substrates accelerates the course of the disease .
10755319	0	P-glycoprotein	85,99	MDR1	101,105	P-glycoprotein	MDR1	5243	5243	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Effect of high-dose cyclosporine on etoposide pharmacodynamics in a trial to reverse P-glycoprotein -LRB- MDR1 gene -RRB- mediated drug resistance .
11160305	0	P-glycoprotein	14,28	MDR1	9,13	P-glycoprotein	MDR1	5243	5243	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro .
11240981	0	P-glycoprotein	52,66	MDR1	84,88	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects .
11369136	0	P-glycoprotein	114,128	MDR1	26,30	P-glycoprotein	MDR1	67078(Tax:10090)	18669(Tax:10090)	Gene	Gene	modulators|amod|START_ENTITY concentrations|nmod|modulators combinations|nmod|concentrations expressing|nmod|combinations expressing|nsubj|Induction Induction|nmod|apoptosis apoptosis|nmod|END_ENTITY	Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P-glycoprotein modulators .
11391622	0	P-glycoprotein	35,49	MDR1	51,55	P-glycoprotein	MDR1	5243	5243	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug-resistance P-glycoprotein -LRB- MDR1 -RRB- in human brain_tumors .
11678332	0	P-glycoprotein	12,26	MDR1	28,32	P-glycoprotein	MDR1	5243	5243	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of P-glycoprotein -LRB- MDR1 -RRB- polymorphisms and mutations in colorectal_cancer .
12426522	0	P-glycoprotein	68,82	MDR1	83,87	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene .
12525496	0	P-glycoprotein	0,14	MDR1	16,20	P-glycoprotein	MDR1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	P-glycoprotein -LRB- MDR1 -RRB- expression in leukemic cells is regulated at two distinct steps , mRNA stabilization and translational initiation .
12724617	0	P-glycoprotein	20,34	MDR1	52,56	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the P-glycoprotein drug transporter MDR1 gene : a possible link between environmental and genetic factors in Parkinson 's _ disease .
1346497	0	P-glycoprotein	22,36	MDR1	16,20	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The role of the MDR1 -LRB- P-glycoprotein -RRB- gene in multidrug resistance in vitro and in vivo .
1359152	0	P-glycoprotein	29,43	MDR1	23,27	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Clinical correlates of MDR1 -LRB- P-glycoprotein -RRB- gene expression in ovarian_and_small-cell_lung_carcinomas .
1360276	0	P-glycoprotein	20,34	MDR1	14,18	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Activation of MDR1 -LRB- P-glycoprotein -RRB- gene expression in human cells by protein_kinase_C agonists .
15695797	0	P-glycoprotein	78,92	MDR1	73,77	P-glycoprotein	MDR1	5243	18669(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo : validation in multidrug-resistant tumors and at the blood-brain barrier .
15824923	0	P-glycoprotein	14,28	MDR1	65,69	P-glycoprotein	MDR1	610926(Tax:9615)	403879(Tax:9615)	Gene	Gene	transport|amod|START_ENTITY Inhibition|nmod|transport function|nsubj|Inhibition function|nmod|resistance resistance|compound|END_ENTITY	Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin .
15912392	0	P-glycoprotein	20,34	MDR1	52,56	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon_cancer patients .
16998727	0	P-glycoprotein	54,68	MDR1	48,52	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of multidrug resistance type 1 gene -LRB- MDR1 -RRB- P-glycoprotein in intractable epilepsy with different aetiologies : a double-labelling and electron microscopy study .
1704872	0	P-glycoprotein	93,107	MDR1	74,78	P-glycoprotein	MDR1	5243	5243	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product -LRB- P-glycoprotein -RRB- : determination of P-glycoprotein expression in multi-drug-resistant KB and CEM cell variants .
17085864	0	P-glycoprotein	57,71	MDR1	0,4	P-glycoprotein	MDR1	5243	5243	Gene	Gene	activity|amod|START_ENTITY associated|nmod|activity associated|nsubjpass|END_ENTITY	MDR1 -LRB- ABCB1 -RRB- gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell_chronic_lymphocytic_leukemia .
17268526	0	P-glycoprotein	96,110	MDR1	77,81	P-glycoprotein	MDR1	5243	5243	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	The farnesyl transferase inhibitor , tipifarnib , is a potent inhibitor of the MDR1 gene product , P-glycoprotein , and demonstrates significant cytotoxic synergism against human leukemia cell lines .
17556798	0	P-glycoprotein	20,34	MDR1	52,56	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphism in the P-glycoprotein drug transporter MDR1 gene in renal transplant patients treated with cyclosporin_A in a Polish population .
17933684	0	P-glycoprotein	60,74	MDR1	83,87	P-glycoprotein	MDR1	67078(Tax:10090)	18669(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|appos|ABCB1 ABCB1|dep|END_ENTITY	Drug-drug interactions affected by the transporter protein , P-glycoprotein -LRB- ABCB1 , MDR1 -RRB- I. Preclinical aspects .
17955490	0	P-glycoprotein	14,28	MDR1	38,42	P-glycoprotein	MDR1	5243	5243	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast_cancer .
18054347	0	P-glycoprotein	8,22	MDR1	88,92	P-glycoprotein	MDR1	5243	396910(Tax:9823)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|cells cells|nummod|END_ENTITY	Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung_adenocarcinoma cells .
18605086	0	P-glycoprotein	22,36	MDR1	17,21	P-glycoprotein	MDR1	5243	5243	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Detection of the MDR1 P-glycoprotein expression and function .
26286731	0	P-glycoprotein	121,135	MDR1	115,119	P-glycoprotein	MDR1	5243	5243	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	The Role of Multidrug Resistance Efflux Pumps in Cancer : Revisiting a JNCI Publication Exploring Expression of the MDR1 -LRB- P-glycoprotein -RRB- Gene .
8099226	0	P-glycoprotein	29,43	MDR1	18,22	P-glycoprotein	MDR1	5243	5243	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|gene gene|compound|END_ENTITY	Expression of the MDR1 gene -LRB- P-glycoprotein -RRB- in breast cancer .
8103760	0	P-glycoprotein	80,94	MDR1	74,78	P-glycoprotein	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variable effects of sodium_butyrate on the expression and function of the MDR1 -LRB- P-glycoprotein -RRB- gene in colon_carcinoma cell lines .
8575863	0	P-glycoprotein	54,68	MDR1	102,106	P-glycoprotein	MDR1	67078(Tax:10090)	18669(Tax:10090)	Gene	Gene	concentrations|nmod|START_ENTITY combination|nmod|concentrations Effect|nmod|combination blockers|nsubj|Effect blockers|advcl|expressing expressing|nsubj|proliferation proliferation|nmod|gene gene|compound|END_ENTITY	Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of MDR1 gene expressing cells .
8900436	0	P-glycoprotein	39,53	MDR1	33,37	P-glycoprotein	MDR1	5243	5243	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cytarabine-induced MDR1 -LRB- P-glycoprotein -RRB- gene activation in human tumor cells by fatty_acid-polyethylene glycol-fatty_acid diesters , novel inhibitors of P-glycoprotein function .
11697834	0	P-glycoprotein	18,32	MRP1	76,80	P-glycoprotein	MRP1	5243	4363	Gene	Gene	proteins|amod|START_ENTITY expression|nmod|proteins expression|dep|1 1|appos|END_ENTITY	The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 -LRB- MRP1 and MRP2 -RRB- in human malignant_mesothelioma .
11901101	0	P-glycoprotein	142,156	MRP1	205,209	P-glycoprotein	MRP1	610926(Tax:9615)	403453(Tax:9615)	Gene	Gene	Pgp|compound|START_ENTITY overexpressing|dobj|Pgp cells|acl|overexpressing cells|appos|protein protein|appos|END_ENTITY	Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney -LRB- MDCK -RRB- cells overexpressing P-glycoprotein -LRB- Pgp -RRB- , multidrug resistance-associated protein -LRB- MRP1 -RRB- , and canalicular multispecific organic anion transporter -LRB- cMOAT -RRB- .
20557448	0	P-glycoprotein	62,76	Mdr1	78,82	P-glycoprotein	Mdr1	443367(Tax:9940)	443367(Tax:9940)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cloning and heterologous expression of the ovine -LRB- Ovis_aries -RRB- P-glycoprotein -LRB- Mdr1 -RRB- in Madin-Darby canine kidney -LRB- MDCK -RRB- cells .
16545584	0	P-glycoprotein	114,128	Mdr1a	88,93	P-glycoprotein	Mdr1a	5243	170913(Tax:10116)	Gene	Gene	transport|amod|START_ENTITY comparison|nmod|transport Development|dep|comparison Development|nmod|cells cells|acl|containing containing|dobj|Abcb1a Abcb1a|appos|END_ENTITY	Development and characterization of LLC-PK1 cells containing Sprague-Dawley_rat Abcb1a -LRB- Mdr1a -RRB- : comparison of rat P-glycoprotein transport to human and mouse .
9580581	0	P-glycoprotein	20,34	Mdr1a	14,19	P-glycoprotein	Mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	disruption|amod|START_ENTITY disruption|amod|END_ENTITY	Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ_PSC_833 , a multidrug resistance-reversing agent , in mice .
25048710	0	P-glycoprotein	81,95	Moesin	15,21	P-glycoprotein	Moesin	5243	4478	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Moesin in the Development of Morphine Analgesic Tolerance through P-glycoprotein at the Blood-Brain Barrier .
10820430	0	P-glycoprotein	25,39	Mrp1	85,89	P-glycoprotein	Mrp1	287115(Tax:10116)	24565(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Functional expression of P-glycoprotein and multidrug_resistance-associated_protein -LRB- Mrp1 -RRB- in primary cultures of rat astrocytes .
23298945	0	P-glycoprotein	19,33	NK-2	97,101	P-glycoprotein	NK-2	5243	7080	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	The elimination of P-glycoprotein over-expressing cancer cells by antimicrobial cationic peptide NK-2 : the unique way of multi-drug resistance modulation .
9016791	0	P-glycoprotein	35,49	P-glycoprotein	89,103	P-glycoprotein	P-glycoprotein	5243	5243	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|C219 C219|appos|antibody antibody|nmod|END_ENTITY	Functional modulation of ATPase of P-glycoprotein by C219 , a monoclonal antibody against P-glycoprotein .
9016791	0	P-glycoprotein	89,103	P-glycoprotein	35,49	P-glycoprotein	P-glycoprotein	5243	5243	Gene	Gene	antibody|nmod|START_ENTITY C219|appos|antibody modulation|nmod|C219 modulation|nmod|END_ENTITY	Functional modulation of ATPase of P-glycoprotein by C219 , a monoclonal antibody against P-glycoprotein .
10500775	0	P-glycoprotein	25,39	P-gp	41,45	P-glycoprotein	P-gp	5243	5243	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Clinical significance of P-glycoprotein -LRB- P-gp -RRB- expression in childhood acute_lymphoblastic_leukemia .
10635304	0	P-glycoprotein	56,70	P-gp	72,76	P-glycoprotein	P-gp	5243	5243	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Merocyanine_540-mediated photodynamic therapy inhibits P-glycoprotein -LRB- P-gp -RRB- activity in adriamycin-resistant K562 cells -RSB- .
11711312	0	P-glycoprotein	20,34	P-gp	36,40	P-glycoprotein	P-gp	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Correlation between P-glycoprotein -LRB- P-gp -RRB- expression in parathyroid and Tc-99m MIBI parathyroid image findings .
1350249	0	P-glycoprotein	19,33	P-gp	35,39	P-glycoprotein	P-gp	5243	5243	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	In vitro effect of P-glycoprotein -LRB- P-gp -RRB- modulators on drug sensitivity of leukemic progenitors -LRB- CFU-L -RRB- in acute_myelogenous_leukemia -LRB- AML -RRB- .
16756642	0	P-glycoprotein	29,43	P-gp	45,49	P-glycoprotein	P-gp	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Peripheral blood lymphocytes P-glycoprotein -LRB- P-gp , gp-170 -RRB- expression in allogenic kidney transplant patients .
25462276	0	P-glycoprotein	82,96	P-gp	98,102	P-glycoprotein	P-gp	5243	5243	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Deconstruction of 6,7-dimethoxy-1 ,2,3,4 - tetrahydroisoquinoline moiety to separate P-glycoprotein -LRB- P-gp -RRB- activity from 2 receptor affinity in mixed P-gp / 2 receptor agents .
17038883	0	P-glycoprotein	25,39	PGP	41,44	P-glycoprotein	PGP	5243	5243	Gene	Gene	relationship|nmod|START_ENTITY relationship|appos|END_ENTITY	The relationship between P-glycoprotein -LRB- PGP -RRB- polymorphisms and response to olanzapine treatment in schizophrenia .
19484671	0	P-glycoprotein	100,114	PGP	116,119	P-glycoprotein	PGP	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein -LRB- PGP -RRB- expression in asthmatic children .
10532420	0	P-glycoprotein	39,53	Pgp	55,58	P-glycoprotein	Pgp	5243	5243	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the multidrug-resistance P-glycoprotein -LRB- Pgp , MDR-1 -RRB- by endothelial cells of the neovasculature in central_nervous_system_tumors .
16595917	0	P-glycoprotein	62,76	Pgp	78,81	P-glycoprotein	Pgp	287115(Tax:10116)	287115(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Relationship between excretion clearance of rhodamine_123 and P-glycoprotein -LRB- Pgp -RRB- expression induced by representative Pgp inducers .
26790551	0	P-glycoprotein	14,28	Pgp	30,33	P-glycoprotein	Pgp	5243	5243	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Evaluation of P-glycoprotein -LRB- Pgp -RRB- expression in human osteosarcoma by high-throughput tissue_microarray .
8845477	0	P-glycoprotein	37,51	Pgp	53,56	P-glycoprotein	Pgp	5243	5243	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Decreased uptake of cyclosporin_A by P-glycoprotein -LRB- Pgp -RRB- expressing CEM_leukemic cells and restoration of normal retention by Pgp blockers .
21459122	0	P-glycoprotein	46,60	Pregnane_X_receptor	0,19	P-glycoprotein	Pregnane X receptor	5243	8856	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Pregnane_X_receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells .
20209493	0	P-glycoprotein	30,44	Rab4	0,4	P-glycoprotein	Rab4	5243	5867	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells .
25901126	0	P-glycoprotein	21,35	Rac1	51,55	P-glycoprotein	Rac1	5243	5879	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric_cancer cells .
25901126	0	P-glycoprotein	21,35	RhoGDI2	0,7	P-glycoprotein	RhoGDI2	5243	397	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric_cancer cells .
10375401	0	P-glycoprotein	46,60	TM5	31,34	P-glycoprotein	TM5	5243	7170	Gene	Gene	loop|nmod|START_ENTITY loop|nmod|END_ENTITY	The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2 .
17982267	0	P-glycoprotein	14,28	TNF	0,3	P-glycoprotein	TNF	5243	7124	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TNF activates P-glycoprotein in cerebral microvascular endothelial cells .
21281239	0	P-glycoprotein	16,30	WAVE1	0,5	P-glycoprotein	WAVE1	5243	8936	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells .
20929136	0	P-glycoprotein	95,109	Y-box_binding_protein-1	53,76	P-glycoprotein	Y-box binding protein-1	5243	4904	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of changwelqing on nuclear translocation of Y-box_binding_protein-1 and expression of P-glycoprotein in human colon_cancer cell line with drug-resistance induced by vincristine -RSB- .
18588889	0	P-glycoprotein	0,14	breast_cancer_resistance_protein	44,76	P-glycoprotein	breast cancer resistance protein	5243	9429	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	P-glycoprotein down-regulates expression of breast_cancer_resistance_protein in a drug-free state .
12138126	0	P-glycoprotein	21,35	cyclooxygenase-2	40,56	P-glycoprotein	cyclooxygenase-2	287115(Tax:10116)	29527(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MDR-1 -LRB- P-glycoprotein -RRB- by cyclooxygenase-2 .
10663638	0	P-glycoprotein	10,24	cyclosporin_A	41,54	P-glycoprotein	cyclosporin A	5243	1161	Gene	Gene	Effect|nmod|START_ENTITY modulation|nsubj|Effect modulation|nmod|END_ENTITY	Effect of P-glycoprotein modulation with cyclosporin_A on cerebrospinal fluid penetration of doxorubicin in non-human primates .
12673668	0	P-glycoprotein	51,65	cyclosporin_A	77,90	P-glycoprotein	cyclosporin A	67078(Tax:10090)	71991(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Potentiation of domperidone-induced catalepsy by a P-glycoprotein inhibitor , cyclosporin_A .
21480191	0	P-glycoprotein	139,153	cytochrome_P450_3A4	119,138	P-glycoprotein	cytochrome P450 3A4	5243	1576	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine_toxicity in the presence of cytochrome_P450_3A4 / P-glycoprotein inhibitors .
21286781	0	P-glycoprotein	57,71	cytotoxic_ribonuclease	2,24	P-glycoprotein	cytotoxic ribonuclease	5243	6037	Gene	Gene	level|nmod|START_ENTITY reduces|dobj|level reduces|nsubj|END_ENTITY	A cytotoxic_ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines .
1673636	0	P-glycoprotein	62,76	erythroid_differentiation_factor	14,46	P-glycoprotein	erythroid differentiation factor	5243	3624	Gene	Gene	expression|amod|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|END_ENTITY	Inhibition by erythroid_differentiation_factor -LRB- activin A -RRB- of P-glycoprotein expression in multidrug-resistant human K562 erythroleukemia cells .
11989653	0	P-glycoprotein	99,113	extracellular-signal_regulated_protein_kinase	42,87	P-glycoprotein	extracellular-signal regulated protein kinase	67078(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Reversal effect of specific inhibitors of extracellular-signal_regulated_protein_kinase pathway on P-glycoprotein mediated vincristine resistance of L1210 cells .
21780101	0	P-glycoprotein	0,14	ezrin	24,29	P-glycoprotein	ezrin	5243	7430	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	P-glycoprotein binds to ezrin at amino_acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma .
10816597	0	P-glycoprotein	44,58	heat-shock_transcription_factor_1	91,124	P-glycoprotein	heat-shock transcription factor 1	5243	3297	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of multidrug_resistance_1 -LRB- MDR1 -RRB- / P-glycoprotein gene expression and activity by heat-shock_transcription_factor_1 -LRB- HSF1 -RRB- .
12130739	0	P-glycoprotein	38,52	interleukin-2	10,23	P-glycoprotein	interleukin-2	67078(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of interleukin-2 on intestinal P-glycoprotein expression and functionality in mice .
10971394	0	P-glycoprotein	118,132	lung_resistance-related_protein	16,47	P-glycoprotein	lung resistance-related protein	5243	9961	Gene	Gene	Significance|nmod|START_ENTITY Significance|nmod|END_ENTITY	Significance of lung_resistance-related_protein in the clinical outcome of acute leukaemic patients with reference to P-glycoprotein .
1678252	0	P-glycoprotein	20,34	mdr-1	14,19	P-glycoprotein	mdr-1	5243	5243	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of mdr-1 / P-glycoprotein in human neuroblastoma .
8094079	0	P-glycoprotein	16,30	mdr-1	10,15	P-glycoprotein	mdr-1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Increased mdr-1 / P-glycoprotein expression after treatment of human colon_carcinoma cells with P-glycoprotein antagonists .
2876781	0	P-glycoprotein	81,95	mdr1	75,79	P-glycoprotein	mdr1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Internal duplication and homology with bacterial_transport_proteins in the mdr1 -LRB- P-glycoprotein -RRB- gene from multidrug-resistant human cells .
2897240	0	P-glycoprotein	122,136	mdr1	116,120	P-glycoprotein	mdr1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 -LRB- P-glycoprotein -RRB- gene .
7654329	0	P-glycoprotein	23,37	mdr1	18,22	P-glycoprotein	mdr1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Expression of the mdr1 P-glycoprotein gene : a mechanism of escape from glucocorticoid-induced apoptosis .
9333100	0	P-glycoprotein	19,33	mdr1	35,39	P-glycoprotein	mdr1	5243	5243	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of intestinal P-glycoprotein -LRB- mdr1 -RRB- in interpatient variation in the oral bioavailability of cyclosporine .
9558371	0	P-glycoprotein	14,28	mdr1	128,132	P-glycoprotein	mdr1	5243	5243	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of P-glycoprotein and recovery of drug sensitivity of human acute leukemic blast cells by multidrug resistance gene -LRB- mdr1 -RRB- antisense oligonucleotides .
10516633	0	P-glycoprotein	12,26	mdr1a	112,117	P-glycoprotein	mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|studies studies|nmod|mice mice|amod|END_ENTITY	The role of P-glycoprotein in blood-brain barrier transport of morphine : transcortical microdialysis studies in mdr1a -LRB- - / - -RRB- and mdr1a -LRB- + / + -RRB- mice .
11496955	0	P-glycoprotein	16,30	mdr1a	10,15	P-glycoprotein	mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	disruption|amod|START_ENTITY disruption|amod|END_ENTITY	Effect of mdr1a P-glycoprotein gene disruption , gender , and substrate concentration on brain uptake of selected compounds .
11959808	0	P-glycoprotein	14,28	mdr1a	111,116	P-glycoprotein	mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	effects|amod|START_ENTITY Resolution|nmod|effects permeability|nsubj|Resolution permeability|xcomp|using using|nmod|mice mice|amod|END_ENTITY	Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a -LRB- - / - -RRB- mice .
12807720	0	P-glycoprotein	12,26	mdr1a	70,75	P-glycoprotein	mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|disruption disruption|nmod|formation formation|amod|END_ENTITY	The role of P-glycoprotein in intestinal tumorigenesis : disruption of mdr1a suppresses polyp formation in Apc -LRB- Min / + -RRB- mice .
24985475	0	P-glycoprotein	10,24	mdr1a	128,133	P-glycoprotein	mdr1a	287115(Tax:10116)	170913(Tax:10116)	Gene	Gene	Impact|nmod|START_ENTITY Impact|dep|comparison comparison|acl|using using|dobj|rats rats|amod|END_ENTITY	Impact of P-glycoprotein on blood-retinal barrier permeability : comparison of blood-aqueous_humor and blood-brain barrier using mdr1a knockout rats .
7910522	0	P-glycoprotein	30,44	mdr1a	24,29	P-glycoprotein	mdr1a	5243	18671(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency_in_the_blood-brain barrier and to increased sensitivity to drugs .
1381362	0	P-glycoprotein	13,27	mdr2	0,4	P-glycoprotein	mdr2	5243	5244	Gene	Gene	expressed|nsubj|START_ENTITY encodes|ccomp|expressed encodes|nsubj|END_ENTITY	mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies .
7977654	0	P-glycoprotein	44,58	mdr2	39,43	P-glycoprotein	mdr2	5243	18670(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Mice with homozygous disruption of the mdr2 P-glycoprotein gene .
9020871	0	P-glycoprotein	19,33	mdr2	14,18	P-glycoprotein	mdr2	67078(Tax:10090)	18670(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of mdr2 P-glycoprotein expression by bile_salts .
10915741	0	P-glycoprotein	37,51	multidrug_resistance_2	14,36	P-glycoprotein	multidrug resistance 2	287115(Tax:10116)	24891(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of multidrug_resistance_2 P-glycoprotein expression by bile_salts in rats and in primary cultures of rat hepatocytes .
1974900	0	P-glycoprotein	53,67	multidrug_resistance_gene	18,43	P-glycoprotein	multidrug resistance gene	5243	5243	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|product product|amod|END_ENTITY	Expression of the multidrug_resistance_gene product -LRB- P-glycoprotein -RRB- in human normal and tumor tissues .
1363104	0	P-glycoprotein	77,91	multidrug_resistance_gene_1	40,67	P-glycoprotein	multidrug resistance gene 1	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|nmod|product product|amod|END_ENTITY	Preferential expression and activity of multidrug_resistance_gene_1 product -LRB- P-glycoprotein -RRB- , a functionally active efflux pump , in human CD8 + T cells : a role in cytotoxic effector function .
23018344	0	P-glycoprotein	86,100	p38	14,17	P-glycoprotein	p38	5243	1432	Gene	Gene	associated|nmod|START_ENTITY resistance|acl|associated diminishes|dobj|resistance diminishes|nsubj|Inhibition Inhibition|nmod|MAPK MAPK|amod|END_ENTITY	Inhibition of p38 MAPK diminishes doxorubicin-induced drug resistance associated with P-glycoprotein in human leukemia K562 cells .
9988237	0	P-glycoprotein	0,14	p53	45,48	P-glycoprotein	p53	5243	7157	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	P-glycoprotein is positively correlated with p53 in human oral pre-malignant and malignant lesions and is associated with poor prognosis .
22927137	0	P-glycoprotein	55,69	pregnane-X-receptor	85,104	P-glycoprotein	pregnane-X-receptor	287115(Tax:10116)	84385(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats .
15258100	0	P-glycoprotein	27,41	pregnane_X_receptor	61,80	P-glycoprotein	pregnane X receptor	5243	8856	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Levothyroxine up-regulates P-glycoprotein independent of the pregnane_X_receptor .
15124210	0	P-glycoprotein	73,87	tumor_necrosis_factor-alpha	10,37	P-glycoprotein	tumor necrosis factor-alpha	5243	7124	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha and interferon-gamma on intestinal P-glycoprotein expression , activity , and localization in Caco-2 cells .
22678786	0	P-gp	40,44	ERK	59,62	P-gp	ERK	5243	5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- Effect of glucosylceramide_synthase on P-gp expression by ERK signal transduction pathway in leukemia multi-drug resistance cell line -RSB- .
12969528	0	P-gp	41,45	HSP70	15,20	P-gp	HSP70	5243	3308	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of HSP70 and P-glycoprotein -LRB- P-gp -RRB- in human hepatocarcinoma HepG2 cells induced by heat_shock and inhibiting effect of quercetin on them -RSB- .
23605320	0	P-gp	43,47	HuR	12,15	P-gp	HuR	5243	1994	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|compound|END_ENTITY	Cytoplasmic HuR expression correlates with P-gp , HER-2 positivity , and poor outcome in breast_cancer .
16122788	0	P-gp	5,9	MDR1	0,4	P-gp	MDR1	283871	5243	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MDR1 P-gp expression and activity in intact human placental tissue ; upregulation by retroviral transduction .
10500775	0	P-gp	41,45	P-glycoprotein	25,39	P-gp	P-glycoprotein	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Clinical significance of P-glycoprotein -LRB- P-gp -RRB- expression in childhood acute_lymphoblastic_leukemia .
10635304	0	P-gp	72,76	P-glycoprotein	56,70	P-gp	P-glycoprotein	5243	5243	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Merocyanine_540-mediated photodynamic therapy inhibits P-glycoprotein -LRB- P-gp -RRB- activity in adriamycin-resistant K562 cells -RSB- .
11711312	0	P-gp	36,40	P-glycoprotein	20,34	P-gp	P-glycoprotein	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Correlation between P-glycoprotein -LRB- P-gp -RRB- expression in parathyroid and Tc-99m MIBI parathyroid image findings .
1350249	0	P-gp	35,39	P-glycoprotein	19,33	P-gp	P-glycoprotein	5243	5243	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	In vitro effect of P-glycoprotein -LRB- P-gp -RRB- modulators on drug sensitivity of leukemic progenitors -LRB- CFU-L -RRB- in acute_myelogenous_leukemia -LRB- AML -RRB- .
16756642	0	P-gp	45,49	P-glycoprotein	29,43	P-gp	P-glycoprotein	5243	5243	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Peripheral blood lymphocytes P-glycoprotein -LRB- P-gp , gp-170 -RRB- expression in allogenic kidney transplant patients .
25462276	0	P-gp	98,102	P-glycoprotein	82,96	P-gp	P-glycoprotein	5243	5243	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Deconstruction of 6,7-dimethoxy-1 ,2,3,4 - tetrahydroisoquinoline moiety to separate P-glycoprotein -LRB- P-gp -RRB- activity from 2 receptor affinity in mixed P-gp / 2 receptor agents .
19813763	0	P-gp	50,54	P-gp	58,62	P-gp	P-gp	5243	5243	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|cells cells|compound|END_ENTITY	Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells -LRB- NCI-ADR-RES -RRB- and placental cells -LRB- JAR -RRB- .
19813763	0	P-gp	58,62	P-gp	50,54	P-gp	P-gp	5243	5243	Gene	Gene	cells|compound|START_ENTITY regulation|nmod|cells regulation|nmod|END_ENTITY	Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells -LRB- NCI-ADR-RES -RRB- and placental cells -LRB- JAR -RRB- .
22678786	0	P-gp	40,44	glucosylceramide_synthase	11,36	P-gp	glucosylceramide synthase	5243	7357	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of glucosylceramide_synthase on P-gp expression by ERK signal transduction pathway in leukemia multi-drug resistance cell line -RSB- .
9129046	0	P-selectin	49,59	CD24	0,4	P-selectin	CD24	6403	100133941	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	CD24 , a mucin-type glycoprotein , is a ligand for P-selectin on human tumor cells .
18641098	0	P-selectin	130,140	CD40_ligand	8,19	P-selectin	CD40 ligand	6403	959	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Soluble CD40_ligand , platelet surface CD40_ligand , and total platelet CD40_ligand in atrial_fibrillation : relationship to soluble P-selectin , stroke risk factors , and risk factor intervention .
10694482	0	P-selectin	79,89	CD62	91,95	P-selectin	CD62	6403	6403	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Flow cytometric parameters for characterizing platelet activation by measuring P-selectin -LRB- CD62 -RRB- expression : theoretical consideration and evaluation in thrombin-treated platelet populations .
10397916	0	P-selectin	23,33	CD62P	35,40	P-selectin	CD62P	6403	6403	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of P-selectin -LRB- CD62P -RRB- by endothelial cells seeded onto synthetic arterial prostheses -LRB- PET , Dacron -RRB- is correlated with leukocyte interactions .
12543548	0	P-selectin	23,33	CD62P	16,21	P-selectin	CD62P	6403	100009695(Tax:9796)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Equine platelet CD62P -LRB- P-selectin -RRB- expression : a phenotypic and morphologic study .
15166936	0	P-selectin	67,77	CD62P	79,84	P-selectin	CD62P	6403	6403	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The effect of hormone replacement therapy on Ca2 + mobilization and P-selectin -LRB- CD62P -RRB- expression in platelets examined under flow cytometry .
18482194	0	P-selectin	38,48	CD62P	31,36	P-selectin	CD62P	6403	6403	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Flow cytometric measurement of CD62P -LRB- P-selectin -RRB- expression on platelets : a multicenter optimization and standardization effort .
21245745	0	P-selectin	52,62	CD62P	64,69	P-selectin	CD62P	6403	6403	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Platelet function alterations and their relation to P-selectin -LRB- CD62P -RRB- expression in children with iron_deficiency anemia .
23484959	0	P-selectin	14,24	CD62P	26,31	P-selectin	CD62P	6403	6403	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of P-selectin -LRB- CD62P -RRB- on platelets after thrombin and ADP in hypotrophic and healthy , full-term newborns .
7531810	0	P-selectin	26,36	CD62P	46,51	P-selectin	CD62P	6403	6403	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated plasma levels of P-selectin -LRB- GMP-140 / CD62P -RRB- in patients with Plasmodium_falciparum malaria .
1372646	0	P-selectin	29,39	GMP-140	20,27	P-selectin	GMP-140	6403	6403	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of GMP-140 -LRB- P-selectin -RRB- as a circulating plasma protein .
8579578	0	P-selectin	54,64	GMP-140	66,73	P-selectin	GMP-140	6403	6403	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Cross-linking_of_the_ninth_consensus repeat domain of P-selectin -LRB- GMP-140 , CD62P -RRB- with a monoclonal antibody enhanced leukocyte adhesive activity .
11071121	0	P-selectin	23,33	P-selectin	59,69	P-selectin	P-selectin	6403	6403	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of platelet P-selectin and detection of soluble P-selectin , NPY and RANTES in patients with inflammatory_bowel_disease .
11071121	0	P-selectin	59,69	P-selectin	23,33	P-selectin	P-selectin	6403	6403	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of platelet P-selectin and detection of soluble P-selectin , NPY and RANTES in patients with inflammatory_bowel_disease .
21497813	0	P-selectin	4,14	P-selectin	60,70	P-selectin	P-selectin	6403	6403	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	The P-selectin gene Pro715 allele and low levels of soluble P-selectin are associated with reduced P2Y12 adenosine_diphosphate receptor reactivity in clopidogrel-treated patients .
21497813	0	P-selectin	60,70	P-selectin	4,14	P-selectin	P-selectin	6403	6403	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	The P-selectin gene Pro715 allele and low levels of soluble P-selectin are associated with reduced P2Y12 adenosine_diphosphate receptor reactivity in clopidogrel-treated patients .
23421771	0	P-selectin	110,120	P-selectin	67,77	P-selectin	P-selectin	6403	6403	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|END_ENTITY	P-selectin paradox and dementia of the Alzheimer type : circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised .
23421771	0	P-selectin	67,77	P-selectin	110,120	P-selectin	P-selectin	6403	6403	Gene	Gene	increased|nsubjpass|START_ENTITY increased|nmod|END_ENTITY	P-selectin paradox and dementia of the Alzheimer type : circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised .
7686912	0	P-selectin	104,114	P-selectin	64,74	P-selectin	P-selectin	6403	6403	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin .
7686912	0	P-selectin	64,74	P-selectin	104,114	P-selectin	P-selectin	6403	6403	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin .
10648000	0	P-selectin	37,47	P-selectin_glycoprotein_ligand-1	65,97	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|contribution contribution|nmod|END_ENTITY	Neonatal neutrophil interaction with P-selectin : contribution of P-selectin_glycoprotein_ligand-1 and sialic_acid .
10713099	0	P-selectin	100,110	P-selectin_glycoprotein_ligand-1	27,59	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	binding|nmod|START_ENTITY determinants|nmod|binding determinants|amod|END_ENTITY	Noncovalent association of P-selectin_glycoprotein_ligand-1 and minimal determinants for binding to P-selectin .
12393631	0	P-selectin	94,104	P-selectin_glycoprotein_ligand-1	30,62	P-selectin	P-selectin glycoprotein ligand-1	6403	20345(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubj|residues residues|nmod|END_ENTITY	N-terminal residues in murine P-selectin_glycoprotein_ligand-1 required for binding to murine P-selectin .
15026421	0	P-selectin	182,192	P-selectin_glycoprotein_ligand-1	135,167	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	rolling|nmod|START_ENTITY enzyme|advcl|rolling enzyme|dobj|core core|nmod|END_ENTITY	Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin_glycoprotein_ligand-1 in rolling on P-selectin .
24244398	0	P-selectin	49,59	P-selectin_glycoprotein_ligand-1	117,149	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Bromelain decreases neutrophil interactions with P-selectin , but not E-selectin , in vitro by proteolytic cleavage of P-selectin_glycoprotein_ligand-1 .
7532174	0	P-selectin	74,84	P-selectin_glycoprotein_ligand-1	0,32	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	neutrophils|nmod|START_ENTITY rolling|nmod|neutrophils mediates|dobj|rolling mediates|nsubj|END_ENTITY	P-selectin_glycoprotein_ligand-1 mediates rolling of human neutrophils on P-selectin .
7559387	0	P-selectin	96,106	P-selectin_glycoprotein_ligand-1	22,54	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	affinity|nmod|START_ENTITY required|nmod|affinity required|nsubjpass|sulfation sulfation|nmod|END_ENTITY	Tyrosine sulfation of P-selectin_glycoprotein_ligand-1 is required for high affinity binding to P-selectin .
9028320	0	P-selectin	62,72	P-selectin_glycoprotein_ligand-1	0,32	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	P-selectin_glycoprotein_ligand-1 is essential for adhesion to P-selectin but not E-selectin in stably transfected hematopoietic cell lines .
9310489	0	P-selectin	18,28	P-selectin_glycoprotein_ligand-1	101,133	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Soluble monomeric P-selectin containing only the lectin and epidermal_growth_factor domains binds to P-selectin_glycoprotein_ligand-1 on leukocytes .
9507018	0	P-selectin	98,108	P-selectin_glycoprotein_ligand-1	41,73	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	required|nmod|START_ENTITY required|nsubj|Identification Identification|nmod|residues residues|nmod|END_ENTITY	Identification of N-terminal residues on P-selectin_glycoprotein_ligand-1 required for binding to P-selectin .
9645612	0	P-selectin	24,34	P-selectin_glycoprotein_ligand-1	74,106	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	START_ENTITY|acl:relcl|supports supports|nmod|END_ENTITY	A functional epitope on P-selectin that supports binding of P-selectin to P-selectin_glycoprotein_ligand-1 but not to sialyl_Lewis_X oligosaccharides .
9645612	0	P-selectin	60,70	P-selectin_glycoprotein_ligand-1	74,106	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	binding|nmod|START_ENTITY supports|xcomp|binding supports|nmod|END_ENTITY	A functional epitope on P-selectin that supports binding of P-selectin to P-selectin_glycoprotein_ligand-1 but not to sialyl_Lewis_X oligosaccharides .
9660879	0	P-selectin	94,104	P-selectin_glycoprotein_ligand-1	16,48	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	recognition|nmod|START_ENTITY required|nmod|recognition required|nsubj|Dimerization Dimerization|nmod|END_ENTITY	Dimerization of P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- required for optimal recognition of P-selectin .
9829984	0	P-selectin	33,43	P-selectin_glycoprotein_ligand-1	55,87	P-selectin	P-selectin glycoprotein ligand-1	6403	6404	Gene	Gene	analysis|nmod|START_ENTITY analysis|amod|END_ENTITY	Affinity and kinetic analysis of P-selectin binding to P-selectin_glycoprotein_ligand-1 .
15155098	0	P-selectin	63,73	P38_mitogen-activated_protein_kinase	9,45	P-selectin	P38 mitogen-activated protein kinase	6403	1432	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Role of P38_mitogen-activated_protein_kinase in expression of P-selectin on human umbilical vein endothelial cells -RSB- .
11030527	0	P-selectin	21,31	PSGL-1	108,114	P-selectin	PSGL-1	6403	6404	Gene	Gene	microparticles|amod|START_ENTITY expressing|dobj|microparticles Platelets|acl|expressing concentrates|nsubj|Platelets concentrates|nmod|END_ENTITY	Platelets expressing P-selectin and platelet-derived microparticles in stored platelet concentrates bind to PSGL-1 on filtrated leukocytes .
11566773	0	P-selectin	79,89	PSGL-1	52,58	P-selectin	PSGL-1	6403	6404	Gene	Gene	adhesion|nmod|START_ENTITY adhesion|compound|END_ENTITY	Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin .
11916843	0	P-selectin	89,99	PSGL-1	14,20	P-selectin	PSGL-1	6403	6404	Gene	Gene	clusters|amod|START_ENTITY stabilizes|dobj|clusters stabilizes|nsubj|Comparison Comparison|nmod|microbead microbead|dep|END_ENTITY	Comparison of PSGL-1 microbead and neutrophil rolling : microvillus elongation stabilizes P-selectin bond clusters .
12036880	0	P-selectin	108,118	PSGL-1	18,24	P-selectin	PSGL-1	6403	6404	Gene	Gene	rolling|nmod|START_ENTITY essential|xcomp|rolling essential|nsubj|Attachment Attachment|nmod|domain domain|amod|cytoplasmic cytoplasmic|amod|END_ENTITY	Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin .
15653735	2	P-selectin	111,121	PSGL-1	140,146	P-selectin	PSGL-1	6403	6404	Gene	Gene	dissociation|amod|START_ENTITY terminated|nmod|dissociation terminated|nmod|END_ENTITY	Tether flow terminated by P-selectin dissociation from PSGL-1 .
16100264	0	P-selectin	109,119	PSGL-1	102,108	P-selectin	PSGL-1	6403	6404	Gene	Gene	lifetime|compound|START_ENTITY lifetime|compound|END_ENTITY	Neutrophil-bead collision assay : pharmacologically induced changes in membrane mechanics regulate the PSGL-1 / P-selectin adhesion lifetime .
16387772	0	P-selectin	16,26	PSGL-1	27,33	P-selectin	PSGL-1	6403	6404	Gene	Gene	bonds|amod|START_ENTITY bonds|compound|END_ENTITY	Biomechanics of P-selectin PSGL-1 bonds : shear threshold and integrin-independent cell adhesion .
17267403	0	P-selectin	77,87	PSGL-1	126,132	P-selectin	PSGL-1	6403	6404	Gene	Gene	interactions|amod|START_ENTITY interactions|appos|END_ENTITY	Impact of carrier stiffness and microtopology on two-dimensional kinetics of P-selectin and P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- interactions .
19262138	0	P-selectin	0,10	PSGL-1	23,29	P-selectin	PSGL-1	6403	6404	Gene	Gene	cross-links|amod|START_ENTITY END_ENTITY|nsubj|cross-links	P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent , but GPCR-independent mechanism .
19403178	0	P-selectin	41,51	PSGL-1	7,13	P-selectin	PSGL-1	6403	6404	Gene	Gene	required|nmod|START_ENTITY required|nsubj|modifications modifications|compound|END_ENTITY	Equine PSGL-1 modifications required for P-selectin binding .
19962723	0	P-selectin	0,10	PSGL-1	12,18	P-selectin	PSGL-1	6403	6404	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	P-selectin / PSGL-1 inhibitors versus enoxaparin in the resolution of venous_thrombosis : a meta-analysis .
21144558	0	P-selectin	111,121	PSGL-1	63,69	P-selectin	PSGL-1	6403	6404	Gene	Gene	immobilised|dobj|START_ENTITY differences|acl|immobilised differences|nmod|neutrophils neutrophils|nmod|carriers carriers|nmod|END_ENTITY	Phenotypic differences of human neutrophils of carriers of the PSGL-1 A and B-allele in binding to immobilised P-selectin under flow conditions .
25824568	0	P-selectin	41,51	PSGL-1	26,32	P-selectin	PSGL-1	6403	6404	Gene	Gene	inhibit|dobj|START_ENTITY inhibit|nsubj|analogues analogues|nmod|END_ENTITY	Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo .
7585949	0	P-selectin	75,85	PSGL-1	52,58	P-selectin	PSGL-1	6403	6404	Gene	Gene	critical|nmod|START_ENTITY critical|nsubj|segment segment|nmod|terminus terminus|nmod|END_ENTITY	A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding .
7585950	0	P-selectin	22,32	PSGL-1	0,6	P-selectin	PSGL-1	6403	6404	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus .
7585950	0	P-selectin	22,32	PSGL-1	88,94	P-selectin	PSGL-1	6403	6404	Gene	Gene	recognition|nmod|START_ENTITY controlled|nsubjpass|recognition controlled|nmod|consensus consensus|nmod|terminus terminus|amod|END_ENTITY	PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus .
7592904	0	P-selectin	113,123	PSGL-1	154,160	P-selectin	PSGL-1	6403	6404	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A novel cobra venom metalloproteinase , mocarhagin , cleaves a 10-amino_acid peptide from the mature N terminus of P-selectin glycoprotein ligand receptor , PSGL-1 , and abolishes P-selectin binding .
9660879	0	P-selectin	94,104	PSGL-1	50,56	P-selectin	PSGL-1	6403	6404	Gene	Gene	recognition|nmod|START_ENTITY required|nmod|recognition required|nsubj|Dimerization Dimerization|nmod|P-selectin_glycoprotein_ligand-1 P-selectin_glycoprotein_ligand-1|appos|END_ENTITY	Dimerization of P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- required for optimal recognition of P-selectin .
19948214	0	P-selectin	37,47	SELP	49,53	P-selectin	SELP	6403	6403	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of a large deletion in the P-selectin -LRB- SELP -RRB- gene .
10899315	0	P-selectin	85,95	TNF-alpha	31,40	P-selectin	TNF-alpha	6403	7124	Gene	Gene	release|nmod|START_ENTITY release|nsubj|induction induction|nmod|END_ENTITY	Density-dependent induction of TNF-alpha release from human monocytes by immobilized P-selectin .
16793694	0	P-selectin	23,33	Von_Willebrand_factor	0,21	P-selectin	Von Willebrand factor	6403	7450	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Von_Willebrand_factor , P-selectin and fibrinogen levels in patients with acute ischaemic and haemorrhagic_stroke , and their relationship with stroke sub-type and functional outcome .
11229826	0	P-selectin	18,28	fibrinogen	98,108	P-selectin	fibrinogen	6403	2244	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Increased soluble P-selectin in patients with haematological and breast_cancer : a comparison with fibrinogen , plasminogen activator inhibitor and von_Willebrand factor .
11511124	0	P-selectin	53,63	fibrinogen	30,40	P-selectin	fibrinogen	6403	2244	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Plasma von_Willebrand factor , fibrinogen and soluble P-selectin levels in paroxysmal , persistent and permanent atrial_fibrillation .
12850842	0	P-selectin	61,71	fibrinogen	84,94	P-selectin	fibrinogen	6403	2244	Gene	Gene	expression|amod|START_ENTITY Roxifiban|nmod|expression Roxifiban|amod|binding binding|amod|END_ENTITY	Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression , fibrinogen binding , and microaggregate formation in a phase I dose-finding study : no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa antagonist .
19262138	0	P-selectin	0,10	fibrinogen	66,76	P-selectin	fibrinogen	6403	2244	Gene	Gene	cross-links|amod|START_ENTITY PSGL-1|nsubj|cross-links PSGL-1|nmod|END_ENTITY	P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent , but GPCR-independent mechanism .
19638712	0	P-selectin	10,20	thrombomodulin	66,80	P-selectin	thrombomodulin	6403	7056	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Increased P-selectin expression on platelets and decreased plasma thrombomodulin in Fontan patients .
15466853	0	P-selectin_glycoprotein_ligand-1	6,38	CCL27	93,98	P-selectin glycoprotein ligand-1	CCL27	6404	10850	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus .
17277158	0	P-selectin_glycoprotein_ligand-1	23,55	CD43	0,4	P-selectin glycoprotein ligand-1	CD43	20345(Tax:10090)	20737(Tax:10090)	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	CD43 collaborates with P-selectin_glycoprotein_ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin .
11961238	0	P-selectin_glycoprotein_ligand-1	25,57	G-CSF	77,82	P-selectin glycoprotein ligand-1	G-CSF	6404	1440	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Rapid down modulation of P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 , CD162 -RRB- by G-CSF in humans .
8839831	0	P-selectin_glycoprotein_ligand-1	0,32	L-selectin	58,68	P-selectin glycoprotein ligand-1	L-selectin	6404	6402	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- is a ligand for L-selectin in neutrophil aggregation .
10648000	0	P-selectin_glycoprotein_ligand-1	65,97	P-selectin	37,47	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	contribution|nmod|START_ENTITY interaction|dep|contribution interaction|nmod|END_ENTITY	Neonatal neutrophil interaction with P-selectin : contribution of P-selectin_glycoprotein_ligand-1 and sialic_acid .
10713099	0	P-selectin_glycoprotein_ligand-1	27,59	P-selectin	100,110	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	determinants|amod|START_ENTITY determinants|nmod|binding binding|nmod|END_ENTITY	Noncovalent association of P-selectin_glycoprotein_ligand-1 and minimal determinants for binding to P-selectin .
12393631	0	P-selectin_glycoprotein_ligand-1	30,62	P-selectin	94,104	P-selectin glycoprotein ligand-1	P-selectin	20345(Tax:10090)	6403	Gene	Gene	residues|nmod|START_ENTITY required|nsubj|residues required|nmod|END_ENTITY	N-terminal residues in murine P-selectin_glycoprotein_ligand-1 required for binding to murine P-selectin .
15026421	0	P-selectin_glycoprotein_ligand-1	135,167	P-selectin	182,192	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	core|nmod|START_ENTITY enzyme|dobj|core enzyme|advcl|rolling rolling|nmod|END_ENTITY	Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin_glycoprotein_ligand-1 in rolling on P-selectin .
24244398	0	P-selectin_glycoprotein_ligand-1	117,149	P-selectin	49,59	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Bromelain decreases neutrophil interactions with P-selectin , but not E-selectin , in vitro by proteolytic cleavage of P-selectin_glycoprotein_ligand-1 .
7532174	0	P-selectin_glycoprotein_ligand-1	0,32	P-selectin	74,84	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|rolling rolling|nmod|neutrophils neutrophils|nmod|END_ENTITY	P-selectin_glycoprotein_ligand-1 mediates rolling of human neutrophils on P-selectin .
7559387	0	P-selectin_glycoprotein_ligand-1	22,54	P-selectin	96,106	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	sulfation|nmod|START_ENTITY required|nsubjpass|sulfation required|nmod|affinity affinity|nmod|END_ENTITY	Tyrosine sulfation of P-selectin_glycoprotein_ligand-1 is required for high affinity binding to P-selectin .
9028320	0	P-selectin_glycoprotein_ligand-1	0,32	P-selectin	62,72	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	P-selectin_glycoprotein_ligand-1 is essential for adhesion to P-selectin but not E-selectin in stably transfected hematopoietic cell lines .
9310489	0	P-selectin_glycoprotein_ligand-1	101,133	P-selectin	18,28	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Soluble monomeric P-selectin containing only the lectin and epidermal_growth_factor domains binds to P-selectin_glycoprotein_ligand-1 on leukocytes .
9507018	0	P-selectin_glycoprotein_ligand-1	41,73	P-selectin	98,108	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	residues|nmod|START_ENTITY Identification|nmod|residues required|nsubj|Identification required|nmod|END_ENTITY	Identification of N-terminal residues on P-selectin_glycoprotein_ligand-1 required for binding to P-selectin .
9645612	0	P-selectin_glycoprotein_ligand-1	74,106	P-selectin	24,34	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	supports|nmod|START_ENTITY END_ENTITY|acl:relcl|supports	A functional epitope on P-selectin that supports binding of P-selectin to P-selectin_glycoprotein_ligand-1 but not to sialyl_Lewis_X oligosaccharides .
9645612	0	P-selectin_glycoprotein_ligand-1	74,106	P-selectin	60,70	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	supports|nmod|START_ENTITY supports|xcomp|binding binding|nmod|END_ENTITY	A functional epitope on P-selectin that supports binding of P-selectin to P-selectin_glycoprotein_ligand-1 but not to sialyl_Lewis_X oligosaccharides .
9660879	0	P-selectin_glycoprotein_ligand-1	16,48	P-selectin	94,104	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	Dimerization|nmod|START_ENTITY required|nsubj|Dimerization required|nmod|recognition recognition|nmod|END_ENTITY	Dimerization of P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- required for optimal recognition of P-selectin .
9829984	0	P-selectin_glycoprotein_ligand-1	55,87	P-selectin	33,43	P-selectin glycoprotein ligand-1	P-selectin	6404	6403	Gene	Gene	analysis|amod|START_ENTITY analysis|nmod|END_ENTITY	Affinity and kinetic analysis of P-selectin binding to P-selectin_glycoprotein_ligand-1 .
11080715	0	P-selectin_glycoprotein_ligand_1	27,59	CD162	61,66	P-selectin glycoprotein ligand 1	CD162	6404	6404	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of P-selectin_glycoprotein_ligand_1 -LRB- CD162 -RRB- on human basophils .
14978129	0	P-selectin_glycoprotein_ligand_1	116,148	E-selectin	151,161	P-selectin glycoprotein ligand 1	E-selectin	20345(Tax:10090)	20339(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Recruitment of IFN-gamma-producing -LRB- Th1-like -RRB- cells into the inflamed retina in vivo is preferentially regulated by P-selectin_glycoprotein_ligand_1 :P / E-selectin interactions .
10318892	0	P/CAF	0,5	cyclin_D1	22,31	P/CAF	cyclin D1	8850	595	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	P/CAF associates with cyclin_D1 and potentiates its activation of the estrogen_receptor .
11035066	0	P1-30	19,24	IL-2	46,50	P1-30	IL-2	5934	3558	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	IL-2R_beta agonist P1-30 acts in synergy with IL-2 , IL-4 , IL-9 , and IL-15 : biological and molecular effects .
9202034	0	P11	0,3	S100	28,32	P11	S100	6281	6285	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	P11 , a unique member of the S100 family of calcium-binding proteins , interacts with and inhibits the activity of the 85-kDa cytosolic_phospholipase_A2 .
24379579	0	P115	0,4	macrophage_migration_inhibitory_factor	64,102	P115	macrophage migration inhibitory factor	8615	4282	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|interaction interaction|nmod|END_ENTITY	P115 promotes growth of gastric_cancer through interaction with macrophage_migration_inhibitory_factor .
18343367	0	P120-catenin	0,12	desmoglein_3	113,125	P120-catenin	desmoglein 3	1500	1830	Gene	Gene	partner|nsubj|START_ENTITY partner|dep|identification identification|nmod|site site|nmod|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
18343367	0	P120-catenin	0,12	desmoglein_3	24,36	P120-catenin	desmoglein 3	1500	1830	Gene	Gene	partner|nsubj|START_ENTITY partner|amod|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
11205306	0	P120ctn	46,53	E-cadherin	20,30	P120ctn	E-cadherin	12388(Tax:10090)	12550(Tax:10090)	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of E-cadherin , beta-catenin , P120ctn in patients with transitional cell bladder_cancer .
12612901	0	P14	0,3	p53	98,101	P14	p53	11102	7157	Gene	Gene	methylation|nummod|START_ENTITY associated|nsubjpass|methylation associated|nmod|END_ENTITY	P14 methylation in human colon_cancer is associated with microsatellite_instability and wild-type p53 .
12297306	0	P14ARF	0,6	Mdm2	53,57	P14ARF	Mdm2	1029	4193	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|nmod|END_ENTITY	P14ARF promotes accumulation of SUMO-1 conjugated -LRB- H -RRB- Mdm2 .
7675459	0	P15	61,64	MTS2	66,70	P15	MTS2	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure , expression and mutational analysis of the P15 -LRB- MTS2 -RRB- gene .
22238231	0	P150	53,57	p32	20,23	P150	p32	10036	708	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Binding of cellular p32 protein to the rubella_virus P150 replicase protein via PxxPxR motifs .
24147952	0	P16	66,69	C-myc	87,92	P16	C-myc	1029	4609	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
25872337	0	P16	25,28	COX-2	37,42	P16	COX-2	1029	4513	Gene	Gene	survivin|appos|START_ENTITY survivin|amod|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
25872337	0	P16	25,28	COX-2	37,42	P16	COX-2	1029	4513	Gene	Gene	survivin|appos|START_ENTITY survivin|amod|END_ENTITY	Expressions of survivin , P16 -LRB- INK4a -RRB- , COX-2 , and Ki-67 in cervical_cancer progression reveal the potential clinical application .
26622888	0	P16	64,67	GSTP1	57,62	P16	GSTP1	1029	2950	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Detecting abnormal methylation of tumor suppressor genes GSTP1 , P16 , RIZ1 , and RASSF1A in hepatocellular_carcinoma and its clinical significance .
20581871	0	P16	36,39	HBP1	23,27	P16	HBP1	1029	26959	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Transcriptional factor HBP1 targets P16 -LRB- INK4A -RRB- , upregulating its expression and consequently is involved in Ras-induced premature senescence .
20152798	0	P16	30,33	IKKbeta	0,7	P16	IKKbeta	1029	3551	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	IKKbeta specifically binds to P16 and phosphorylates Ser8 of P16 .
24147952	0	P16	66,69	IMP1	60,64	P16	IMP1	1029	10642	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
16317707	0	P16	48,51	INK4A	52,57	P16	INK4A	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Role of HSP90 , CDC37 , and CRM1 as modulators of P16 -LRB- INK4A -RRB- activity in rat liver carcinogenesis and human liver_cancer .
10398427	0	P16	8,11	INK4a	12,17	P16	INK4a	1029	1029	Gene	Gene	CDKN2A|dep|START_ENTITY CDKN2A|appos|END_ENTITY	CDKN2A -LRB- P16 -LRB- INK4a -RRB- -RRB- and CDK4 mutation analysis in 131 Australian melanoma probands : effect of family history and multiple primary melanomas .
16411180	0	P16	8,11	INK4a	12,17	P16	INK4a	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Role of P16 -LRB- INK4a -RRB- expression in identifying CIN2 or more severe lesions among HPV-positive patients referred for colposcopy after abnormal cytology .
21211322	0	P16	15,18	INK4a	19,24	P16	INK4a	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- Evaluation of P16 -LRB- INK4a -RRB- expression in Thinprep cervical specimens for the predication of high-grade cervical intraepithelial_neoplasia -RSB- .
26261680	0	P16	23,26	INK4a	27,32	P16	INK4a	1029	1029	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Comments on Bu et al. `` P16 -LRB- INK4a -RRB- overexpression and survival in osteosarcoma patients : a meta analysis '' .
9120722	0	P16	15,18	MTS1	20,24	P16	MTS1	1029	1029	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of P16 -LRB- MTS1 -RRB- in node-positive non-small_cell_lung_carcinomas .
24147952	0	P16	66,69	P53	55,58	P16	P53	1029	7157	Gene	Gene	Survivn|appos|START_ENTITY Survivn|compound|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
25890228	0	P16	47,50	P53	42,45	P16	P53	1029	7157	Gene	Gene	mutant|nummod|START_ENTITY mutant|nummod|END_ENTITY	Clinical outcome and expression of mutant P53 , P16 , and Smad4 in lung_adenocarcinoma : a prospective study .
24147952	0	P16	66,69	P62	82,85	P16	P62	1029	23636	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
26622888	0	P16	64,67	RIZ1	69,73	P16	RIZ1	1029	7799	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Detecting abnormal methylation of tumor suppressor genes GSTP1 , P16 , RIZ1 , and RASSF1A in hepatocellular_carcinoma and its clinical significance .
24147952	0	P16	66,69	cyclin_B1	71,80	P16	cyclin B1	1029	891	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
9439668	0	P16INK4A	164,172	CDKN2A	156,162	P16INK4A	CDKN2A	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inherited susceptibility to several cancers but absence of linkage between dysplastic_nevus_syndrome and CDKN2A in a melanoma family with a mutation in the CDKN2A -LRB- P16INK4A -RRB- gene .
23729286	0	P16INK4A	57,65	P53	34,37	P16INK4A	P53	1029	7157	Gene	Gene	L1|compound|START_ENTITY FAS|appos|L1 FAS|compound|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
8668923	0	P17	64,67	gag	68,71	P17	gag	653820	155030(Tax:11676)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Adjuvant properties of montanide_CSA 720 with a recombinant HIV P17 gag protein and synthetic peptide antigens .
12796810	0	P18	26,29	INK4C	30,35	P18	INK4C	1031	1031	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The effects of inhibiting P18 -LRB- INK4C -RRB- expression on the invasion of gastric_adenocarcinoma cell line .
23156673	0	P19	54,57	Akt	83,86	P19	Akt	83430(Tax:10090)	11651(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	N-acetylcysteine enhances neuronal differentiation of P19 embryonic stem cells via Akt and N-cadherin activation .
10715587	0	P19	72,75	BM88_antigen	24,36	P19	BM88 antigen	83430(Tax:10090)	57754(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Early expression of the BM88_antigen during neuronal differentiation of P19 embryonal_carcinoma cells .
9109376	0	P19	75,78	Csk	8,11	P19	Csk	83430(Tax:10090)	12988(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Csk in neural differentiation of the embryonic_carcinoma cell line P19 .
16232120	0	P19	65,68	DMT1	53,57	P19	DMT1	83430(Tax:10090)	18174(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Post-translational and transcriptional regulation of DMT1 during P19 embryonic_carcinoma cell differentiation by retinoic_acid .
10640639	0	P19	33,36	GAP-43	23,29	P19	GAP-43	83430(Tax:10090)	14432(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Targeted disruption of GAP-43 in P19 embryonal_carcinoma cells inhibits neuronal differentiation .
11098153	0	P19	62,65	HES-1	37,42	P19	HES-1	83430(Tax:10090)	15205(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	A novel cis-acting element regulates HES-1 gene expression in P19 embryonal_carcinoma cells treated with retinoic_acid .
1793734	0	P19	91,94	Krox-24	24,31	P19	Krox-24	83430(Tax:10090)	13653(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Regulated expression of Krox-24 and other serum-responsive genes during differentiation of P19 embryonal_carcinoma cells .
15073523	0	P19	69,72	NSSR1	0,5	P19	NSSR1	83430(Tax:10090)	14105(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells promotes|dobj|differentiation promotes|nsubj|END_ENTITY	NSSR1 promotes neuronal differentiation of mouse embryonic_carcinoma P19 cells .
22248690	0	P19	68,71	P2X2	101,105	P19	P2X2	83430(Tax:10090)	231602(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Regulation of neurogenesis and gliogenesis of retinoic_acid-induced P19 embryonal_carcinoma cells by P2X2 and P2X7_receptors studied by RNA interference .
11324569	0	P19	48,51	Wnt-1	27,32	P19	Wnt-1	83430(Tax:10090)	22408(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Neural differentiation of Wnt-1 overexpression P19 cells -RSB- .
7958454	0	P19	85,88	Wnt-1	134,139	P19	Wnt-1	83430(Tax:10090)	22408(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY differentiation|nmod|cells members|nmod|differentiation expression|nmod|members expression|dep|overexpression overexpression|nmod|properties properties|amod|perturbs perturbs|amod|END_ENTITY	Regulated expression of Wnt family members during neuroectodermal differentiation of P19 embryonal_carcinoma cells : overexpression of Wnt-1 perturbs normal differentiation-specific properties .
8302595	0	P19	79,82	Wnt-1	60,65	P19	Wnt-1	83430(Tax:10090)	22408(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY protein|nmod|cells protein|compound|END_ENTITY	Identification and biochemical characterization of secreted Wnt-1 protein from P19 embryonal_carcinoma cells induced to differentiate along the neuroectodermal lineage .
10381633	0	P19	59,62	caspase-3	32,41	P19	caspase-3	83430(Tax:10090)	12367(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	bFGF inhibits the activation of caspase-3 and apoptosis of P19 embryonal_carcinoma cells during neuronal differentiation .
9454748	0	P19	20,23	erythropoietin	38,52	P19	erythropoietin	83430(Tax:10090)	13856(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nsubj|cells produce|dobj|END_ENTITY	Embryonal_carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner .
20598227	0	P19	85,88	map2	55,59	P19	map2	83430(Tax:10090)	17756(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Role of acetylated p53 in regulating the expression of map2 in retinoic_acid-induced P19 cells .
15582350	0	P19	87,90	p38	71,74	P19	p38	83430(Tax:10090)	26416(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells .
11688801	0	P19_and_P20	29,40	Cyt1Aa	66,72	P19 and P20	Cyt1Aa	5759960(Tax:1430)	5759908(Tax:1430)	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of accessory proteins P19_and_P20 on cytolytic activity of Cyt1Aa from Bacillus_thuringiensis_subsp .
11466616	0	P21	0,3	Cdk4	54,58	P21	Cdk4	12575(Tax:10090)	12567(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|activity activity|amod|END_ENTITY	P21 -LRB- Cip1 -RRB- induced by Raf is associated with increased Cdk4 activity in hematopoietic cells .
23167335	0	P21	41,44	MDM2	0,4	P21	MDM2	644914	4193	Gene	Gene	polymorphisms|nummod|START_ENTITY effect|nmod|polymorphisms has|dobj|effect has|nsubj|T309G T309G|compound|END_ENTITY	MDM2 T309G has a synergistic effect with P21 ser31arg single nucleotide polymorphisms on the risk of acute_myeloid_leukemia .
26170892	1	P21	104,107	P27	109,112	P21	P27	24525(Tax:10116)	83571(Tax:10116)	Gene	Gene	Affecting|nummod|START_ENTITY Affecting|nummod|END_ENTITY	-LRB- Du-Zhong -RRB- Lignans Inhibit Angiotensin_II-Stimulated Proliferation by Affecting P21 , P27 , and Bax Expression in Rat Mesangial Cells .
11700890	0	P21	0,3	P53	61,64	P21	P53	1026	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	P21 -LRB- WAF1 -RRB- expression in colorectal_cancer : correlation with P53 and cyclin_D1 expression , clinicopathological parameters and prognosis .
17487067	0	P21	52,55	P53	47,50	P21	P53	24525(Tax:10116)	301300(Tax:10116)	Gene	Gene	PCNA|appos|START_ENTITY PCNA|compound|END_ENTITY	Differential protection and transactivation of P53 , P21 , Bcl2 , PCNA , cyclin_G , and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin .
8732090	0	P21	32,35	P53	37,40	P21	P53	644914	7157	Gene	Gene	expression|nmod|START_ENTITY Detection|nmod|expression Detection|appos|END_ENTITY	-LSB- Detection of the expression of P21 , P53 , P185 proteins and the mutation of ras , p53 genes in colorectal_adenoma_and_carcinoma -RSB- .
11466616	0	P21	0,3	Raf	21,24	P21	Raf	12575(Tax:10090)	387609(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	P21 -LRB- Cip1 -RRB- induced by Raf is associated with increased Cdk4 activity in hematopoietic cells .
11700890	0	P21	0,3	WAF1	5,9	P21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	P21 -LRB- WAF1 -RRB- expression in colorectal_cancer : correlation with P53 and cyclin_D1 expression , clinicopathological parameters and prognosis .
20054800	0	P21	0,3	bax	10,13	P21	bax	644914	581	Gene	Gene	START_ENTITY|appos|pathways pathways|compound|END_ENTITY	P21 , p27 , bax , cathepsin and survivin pathways in macular_dystrophy corneas .
19538337	0	P21	117,120	extracellular_signal-regulated_protein_kinase	71,116	P21	extracellular signal-regulated protein kinase	1026	5594	Gene	Gene	pathways|dep|START_ENTITY pathways|amod|END_ENTITY	Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular_signal-regulated_protein_kinase / P21 -LRB- CIP1 -RRB- / P27 -LRB- KIP1 -RRB- pathways .
8732090	0	P21	32,35	p53	81,84	P21	p53	644914	7157	Gene	Gene	expression|nmod|START_ENTITY Detection|nmod|expression Detection|appos|genes genes|compound|END_ENTITY	-LSB- Detection of the expression of P21 , P53 , P185 proteins and the mutation of ras , p53 genes in colorectal_adenoma_and_carcinoma -RSB- .
9275651	0	P21	71,74	p53	116,119	P21	p53	644914	7157	Gene	Gene	expression|nmod|START_ENTITY significance|nmod|expression significance|nmod|ras ras|appos|genes genes|compound|END_ENTITY	-LSB- Detection and clinical pathological significance of the expression of P21 , P185 , p53 proteins and mutation of ras , p53 genes in transitional cell carcinoma_of_the_bladder -RSB- .
14642618	0	P21	143,146	proliferating_cell_nuclear_antigen	47,81	P21	proliferating cell nuclear antigen	644914	5111	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	In human hepatocellular_carcinoma in cirrhosis proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- is involved in cell proliferation and cooperates with P21 in DNA repair .
12374744	0	P21-activated_kinase-1	0,22	estrogen_receptor-alpha	57,80	P21-activated kinase-1	estrogen receptor-alpha	18479(Tax:10090)	13982(Tax:10090)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	P21-activated_kinase-1 phosphorylates and transactivates estrogen_receptor-alpha and promotes hyperplasia in mammary epithelium .
16452229	0	P21-activated_kinase_1	0,22	estrogen_receptor-alpha	37,60	P21-activated kinase 1	estrogen receptor-alpha	5058	2099	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|activation activation|amod|END_ENTITY	P21-activated_kinase_1 regulation of estrogen_receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation .
18805672	0	P21-activated_kinase_3	21,43	PAK3	45,49	P21-activated kinase 3	PAK3	5063	5063	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Sequence analysis of P21-activated_kinase_3 -LRB- PAK3 -RRB- in chronic schizophrenia with cognitive_impairment .
12356872	0	P21-activated_kinase_4	0,22	integrin_alpha_v_beta_5	38,61	P21-activated kinase 4	integrin alpha v beta 5	10298	3693	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	P21-activated_kinase_4 interacts with integrin_alpha_v_beta_5 and regulates alpha v beta 5-mediated cell migration .
23873832	0	P21-activated_kinase_4	0,22	p57	71,74	P21-activated kinase 4	p57	10298	1028	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	P21-activated_kinase_4 regulates the cyclin-dependent kinase inhibitor p57 -LRB- kip2 -RRB- in human breast_cancer .
16409301	0	P210	0,4	Bcr-abl	5,12	P210	BCR-ABL	2125	25	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	P210 Bcr-abl tyrosine kinase interaction with histone_deacetylase_1 modifies histone H4 acetylation and chromatin structure of chronic_myeloid_leukaemia haematopoietic progenitors .
23611214	0	P210	74,78	bcr-abl	65,72	P210	bcr-abl	2125	25	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	-LSB- A multicenter comparison study on the quantitative detection of bcr-abl -LRB- P210 -RRB- transcript levels in China -RSB- .
2440107	0	P210	17,21	bcr/abl	22,29	P210	bcr/abl	14027(Tax:10090)	25;613	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The CML-specific P210 bcr/abl protein , unlike v-abl , does not transform NIH/3T3 fibroblasts .
16409301	0	P210	0,4	histone_deacetylase_1	46,67	P210	histone deacetylase 1	2125	3065	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	P210 Bcr-abl tyrosine kinase interaction with histone_deacetylase_1 modifies histone H4 acetylation and chromatin structure of chronic_myeloid_leukaemia haematopoietic progenitors .
20696002	0	P25	25,28	Argonaute1	62,72	P25	Argonaute1	54732	26523	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The silencing suppressor P25 of Potato virus X interacts with Argonaute1 and mediates its degradation through the proteasome pathway .
21586279	0	P27	76,79	Bcl-2	81,86	P27	Bcl-2	83571(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Ligustrazine inhibits lipopolysaccharide-induced proliferation by affecting P27 , Bcl-2 expression in rat mesangial cells .
11307151	0	P27	14,17	KIP1	18,22	P27	KIP1	3429	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of P27 -LRB- KIP1 -RRB- is prognostic and independent of MYCN amplification in human neuroblastoma .
17534820	0	P27	27,30	Kip1	31,35	P27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	alterations|nmod|START_ENTITY alterations|appos|END_ENTITY	Optic nerve alterations in P27 -LRB- Kip1 -RRB- knockout mice .
26170892	1	P27	109,112	P21	104,107	P27	P21	83571(Tax:10116)	24525(Tax:10116)	Gene	Gene	Affecting|nummod|START_ENTITY Affecting|nummod|END_ENTITY	-LRB- Du-Zhong -RRB- Lignans Inhibit Angiotensin_II-Stimulated Proliferation by Affecting P21 , P27 , and Bax Expression in Rat Mesangial Cells .
15363035	0	P27	84,87	Skp2	29,33	P27	Skp2	10671	6502	Gene	Gene	degradation|nmod|START_ENTITY molecules|nmod|degradation study|appos|molecules study|nmod|END_ENTITY	Immunohistochemical study of Skp2 and Jab1 , two key molecules in the degradation of P27 , in lung_adenocarcinoma .
16405750	0	P27	70,73	Skp2	16,20	P27	Skp2	10534	6502	Gene	Gene	-RSB-|compound|START_ENTITY Correlation|nmod|-RSB- Correlation|nmod|expression expression|amod|END_ENTITY	-LSB- Correlation of Skp2 expression in gastric_carcinoma to expression of P27 and PTEN -RSB- .
15188025	0	P27	24,27	p53	126,129	P27	p53	3429	7157	Gene	Gene	expression|compound|START_ENTITY decreased|dobj|expression decreased|advcl|complex_hyperplasia complex_hyperplasia|nmod|atypia atypia|dep|correlation correlation|nmod|expression expression|compound|END_ENTITY	Significantly decreased P27 expression in endometrial_carcinoma compared to complex_hyperplasia with atypia -LRB- correlation with p53 expression -RRB- .
9214595	0	P27KIP1	28,35	cyclin_D1	100,109	P27KIP1	cyclin D1	1027	595	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein expression|nmod|lines lines|acl:relcl|over-express over-express|dobj|END_ENTITY	Increased expression of the P27KIP1 protein in human esophageal_cancer cell lines that over-express cyclin_D1 .
19657571	0	P27kip1	39,46	SKP2	0,4	P27kip1	SKP2	1027	6502	Gene	Gene	degradation|nmod|START_ENTITY inhibits|dobj|degradation inhibits|nsubj|siRNA siRNA|compound|END_ENTITY	SKP2 siRNA inhibits the degradation of P27kip1 and down-regulates the expression of MRP in HL-60 / A cells .
18625910	0	P2RX7	24,29	CREB	51,55	P2RX7	CREB	5027	1385	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells .
26853442	0	P2X1	0,4	IL-22	15,20	P2X1	IL-22	5023	50616	Gene	Gene	secretion|nummod|START_ENTITY secretion|compound|END_ENTITY	P2X1 regulated IL-22 secretion by innate lymphoid cells is required for efficient liver_regeneration .
22248690	0	P2X2	101,105	P19	68,71	P2X2	P19	231602(Tax:10090)	83430(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Regulation of neurogenesis and gliogenesis of retinoic_acid-induced P19 embryonal_carcinoma cells by P2X2 and P2X7_receptors studied by RNA interference .
26946194	0	P2X4R	64,69	Akt	17,20	P2X4R	Akt	5025	207	Gene	Gene	Expression|compound|START_ENTITY Role|nmod|Expression Role|nmod|END_ENTITY	Relative Role of Akt , ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression .
21510825	0	P2X7R	48,53	P2X7_receptor	33,46	P2X7R	P2X7 receptor	18439(Tax:10090)	18439(Tax:10090)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	A potential therapeutic role for P2X7_receptor -LRB- P2X7R -RRB- antagonists in the treatment of inflammatory diseases .
25403356	0	P2X7_receptor	17,30	C/EBPb	0,6	P2X7 receptor	C/EBPb	5027	1051	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	C/EBPb regulates P2X7_receptor expression in response to glucose challenge in intestinal epithelial cells .
12747800	0	P2X7_receptor	0,13	ERK1	63,67	P2X7 receptor	ERK1	5027	5595	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	P2X7_receptor activates extracellular signal-regulated kinases ERK1 and ERK2 independently of Ca2 + influx .
21865551	0	P2X7_receptor	4,17	GM-CSF	128,134	P2X7 receptor	GM-CSF	18439(Tax:10090)	12981(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The P2X7_receptor and Pannexin-1 are both required for the promotion of multinucleated macrophages by the inflammatory cytokine GM-CSF .
12869560	0	P2X7_receptor	45,58	HSP90	28,33	P2X7 receptor	HSP90	5027	3320	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Tyrosine phosphorylation of HSP90 within the P2X7_receptor complex negatively regulates P2X7_receptors .
17905568	0	P2X7_receptor	48,61	IL-1_beta	80,89	P2X7 receptor	IL-1 beta	18439(Tax:10090)	16176(Tax:10090)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	In vitro and in vivo evidence for a role of the P2X7_receptor in the release of IL-1_beta in the murine brain .
15472991	0	P2X7_receptor	43,56	IL-1beta	13,21	P2X7 receptor	IL-1beta	5027	3553	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	The cytokine IL-1beta transiently enhances P2X7_receptor expression and function in human astrocytes .
21510825	0	P2X7_receptor	33,46	P2X7R	48,53	P2X7 receptor	P2X7R	18439(Tax:10090)	18439(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	A potential therapeutic role for P2X7_receptor -LRB- P2X7R -RRB- antagonists in the treatment of inflammatory diseases .
17036048	0	P2X7_receptor	88,101	Pannexin-1	0,10	P2X7 receptor	Pannexin-1	5027	24145	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7_receptor .
16301671	0	P2X7_receptor	44,57	caspase-1	16,25	P2X7 receptor	caspase-1	18439(Tax:10090)	12362(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Potentiation of caspase-1 activation by the P2X7_receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis .
24312495	0	P2X7_receptor	109,122	miR-150	0,7	P2X7 receptor	miR-150	5027	406942	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-150 promotes human breast_cancer growth and malignant behavior by targeting the pro-apoptotic purinergic P2X7_receptor .
18682393	0	P2X7_receptor	87,100	miR-186	10,17	P2X7 receptor	miR-186	5027	406962	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7_receptor by activation of instability sites at the 3 ' - untranslated region of the gene that decrease steady-state levels of the transcript .
12424250	0	P2X7_receptor	18,31	p56lck	58,64	P2X7 receptor	p56lck	5027	3932	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nsubj|END_ENTITY	Signaling through P2X7_receptor in human T cells involves p56lck , MAP kinases , and transcription factors AP-1 and NF-kappa_B .
22553206	0	P2X7_receptor	23,36	pannexin-1	105,115	P2X7 receptor	pannexin-1	18439(Tax:10090)	55991(Tax:10090)	Gene	Gene	variants|nmod|START_ENTITY reveal|nsubj|variants reveal|dobj|dependence dependence|nmod|END_ENTITY	Splice variants of the P2X7_receptor reveal differential agonist dependence and functional coupling with pannexin-1 .
23793974	0	P2X7_receptor	28,41	phospholipase_D1	59,75	P2X7 receptor	phospholipase D1	5027	5337	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|amod|END_ENTITY	CAY10593 inhibits the human P2X7_receptor independently of phospholipase_D1 stimulation .
16000618	0	P2Y1	108,112	P2Y2	114,118	P2Y1	P2Y2	25265(Tax:10116)	29597(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
16000618	0	P2Y1	108,112	P2Y4	127,131	P2Y1	P2Y4	25265(Tax:10116)	63843(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
17824841	0	P2Y11	30,35	P2Y1_receptor	54,67	P2Y11	P2Y1 receptor	5032	5028	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Hetero-oligomerization of the P2Y11 receptor with the P2Y1_receptor controls the internalization and ligand selectivity of the P2Y11 receptor .
24723492	0	P2Y12	32,37	PAR4	52,56	P2Y12	PAR4	64805	9002	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation .
17824841	0	P2Y1_receptor	54,67	P2Y11	30,35	P2Y1 receptor	P2Y11	5028	5032	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Hetero-oligomerization of the P2Y11 receptor with the P2Y1_receptor controls the internalization and ligand selectivity of the P2Y11 receptor .
25445826	0	P2Y1_receptor	32,45	RhoA	0,4	P2Y1 receptor	RhoA	18441(Tax:10090)	11848(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	RhoA signaling through platelet P2Y1_receptor controls leukocyte recruitment in allergic mice .
15722198	0	P2Y2	53,57	ERK1/2	76,82	P2Y2	ERK1/2	29597(Tax:10116)	50689;116590	Gene	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	Effects of extracellular nucleotides in the thyroid : P2Y2 receptor-mediated ERK1/2 activation and c-Fos induction in PC Cl3 cells .
24362969	0	P2Y2	124,128	JNK	147,150	P2Y2	JNK	5029	5599	Gene	Gene	activation|nummod|START_ENTITY activation|compound|END_ENTITY	Proliferation of mouse liver stem/progenitor cells induced by plasma from patients with acute_liver_failure is modulated by P2Y2 receptor-mediated JNK activation .
16000618	0	P2Y2	114,118	P2Y1	108,112	P2Y2	P2Y1	29597(Tax:10116)	25265(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
16000618	0	P2Y2	114,118	P2Y4	127,131	P2Y2	P2Y4	29597(Tax:10116)	63843(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
25657827	0	P2Y2	4,8	VE-Cadherin	33,44	P2Y2	VE-Cadherin	5029	1003	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	The P2Y2 Receptor Interacts with VE-Cadherin and VEGF Receptor-2 to Regulate Rac1 Activity in Endothelial Cells .
22298782	0	P2Y2	0,4	lymphotoxin-a	23,36	P2Y2	lymphotoxin-a	5029	4049	Gene	Gene	secretion|nummod|START_ENTITY secretion|amod|END_ENTITY	P2Y2 receptor-mediated lymphotoxin-a secretion regulates intercellular cell adhesion molecule-1 expression in vascular smooth muscle cells .
12802596	0	P2Y2	43,47	mGluR5	35,41	P2Y2	mGluR5	29597(Tax:10116)	14805(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Immunohistochemical expressions of mGluR5 , P2Y2 receptor , PLC-beta1 , and IP3R-I and - II in Merkel cells in rat sinus hair follicles .
16139976	0	P2Y2	0,4	mucin	21,26	P2Y2	mucin	5029	100508689	Gene	Gene	secretion|nummod|START_ENTITY secretion|compound|END_ENTITY	P2Y2 agonist induces mucin secretion via Ca2 + - _ and_inositol_1 ,4,5 - triphosphate-dependent pathway in human middle ear epithelial cells .
9023342	0	P2Y2	27,31	receptor	43,51	P2Y2	receptor	18442(Tax:10090)	18436(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes .
24631773	0	P2Y2_receptor	0,13	IL-6	24,28	P2Y2 receptor	IL-6	5029	3569	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	P2Y2_receptor represses IL-6 expression by valve interstitial cells through Akt : implication for calcific aortic_valve_disease .
16000618	0	P2Y4	127,131	P2Y1	108,112	P2Y4	P2Y1	63843(Tax:10116)	25265(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
16000618	0	P2Y4	127,131	P2Y2	114,118	P2Y4	P2Y2	63843(Tax:10116)	29597(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Dual presynaptic control by ATP of glutamate release via facilitatory P2X1 , P2X2/3 , and P2X3 and inhibitory P2Y1 , P2Y2 , and/or P2Y4 receptors in the rat hippocampus .
21388279	0	P2Y6_receptor	15,28	COX-2	50,55	P2Y6 receptor	COX-2	5031	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Involvement of P2Y6_receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes .
21641579	0	P2Y6_receptor	50,63	interleukin-6	17,30	P2Y6 receptor	interleukin-6	5031	3569	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Pressure induces interleukin-6 expression via the P2Y6_receptor in human dental pulp cells .
21388279	0	P2Y6_receptor	15,28	p38	32,35	P2Y6 receptor	p38	5031	1432	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Involvement of P2Y6_receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes .
16905269	0	P2Y_and_P2X	88,99	STAT3	34,39	P2Y and P2X	STAT3	25265(Tax:10116)	25125(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	P2 purinergic receptors signal to STAT3 in astrocytes : Difference in STAT3 responses to P2Y_and_P2X receptor activation .
16905269	0	P2Y_and_P2X	88,99	STAT3	69,74	P2Y and P2X	STAT3	25265(Tax:10116)	25125(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY STAT3|nmod|activation STAT3|nmod|astrocytes astrocytes|dep|Difference Difference|nmod|responses responses|nummod|END_ENTITY	P2 purinergic receptors signal to STAT3 in astrocytes : Difference in STAT3 responses to P2Y_and_P2X receptor activation .
24816543	0	P30	31,34	Th1	0,3	P30	Th1	201161	51497	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Th1 and Th2 immune response to P30 and ROP18 peptides in human toxoplasmosis .
11548595	0	P300	60,64	AEP	78,81	P300	AEP	2033	5641	Gene	Gene	component|compound|START_ENTITY component|nmod|END_ENTITY	-LSB- Characteristics of the spatio-temporal organization of the P300 component of AEP during the `` active '' and `` passive '' stimulus perception in healthy subjects -RSB- .
23419874	0	P300	0,4	RLIP76	25,31	P300	RLIP76	2033	10928	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	P300 regulates the human RLIP76 promoter activity and gene expression .
17906698	0	P300	0,4	p16	21,24	P300	p16	2033	1029	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|expression expression|amod|END_ENTITY	P300 plays a role in p16 -LRB- INK4a -RRB- expression and cell cycle arrest .
12767454	0	P300	16,20	task_2	60,66	P300	task 2	2033	8645	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	An MEG study of P300 activity during a color discrimination task_2 : source localization study .
23990920	0	P32	42,45	RNase_H1	6,14	P32	RNase H1	708	246243	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Human RNase_H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processing .
24210115	0	P33	41,44	P53	87,90	P33	P53	3621	7157	Gene	Gene	Ac92|appos|START_ENTITY interacts|nsubj|Ac92 interacts|nmod|protein protein|compound|END_ENTITY	The baculovirus sulfhydryl oxidase Ac92 -LRB- P33 -RRB- interacts with the Spodoptera frugiperda P53 protein and oxidizes it in vitro .
11601697	0	P33	23,26	mim-1	8,13	P33	mim-1	396471(Tax:9031)	396471(Tax:9031)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Chicken mim-1 protein , P33 , is a heterophil chemotactic factor present in Salmonella_enteritidis immune lymphokine .
9822744	0	P35	69,72	CDK5	54,58	P35	CDK5	8851	1020	Gene	Gene	START_ENTITY|nsubj|Evidence Evidence|nmod|participation participation|nmod|activator activator|compound|END_ENTITY	Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth .
18508888	0	P35	102,105	P49	73,76	P35	P49	3592	5557	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Reactive-site cleavage residues confer target specificity to baculovirus P49 , a dimeric member of the P35 family of caspase inhibitors .
16336951	0	P38	54,57	COX-2	15,20	P38	COX-2	5594	5743	Gene	Gene	angiogenesis|nmod|START_ENTITY END_ENTITY|nmod|angiogenesis	Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells .
18657608	0	P38	0,3	COX-2	18,23	P38	COX-2	1432	5743	Gene	Gene	MAPK|compound|START_ENTITY mediates|nsubj|MAPK mediates|dobj|expression expression|compound|END_ENTITY	P38 MAPK mediates COX-2 gene expression by corticosterone in cardiomyocytes .
26407843	0	P38	0,3	Dickkopf-1	32,42	P38	Dickkopf-1	1432	22943	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	P38 regulates the Wnt inhibitor Dickkopf-1 in breast_cancer .
18647594	0	P38	44,47	EMMPRIN	21,28	P38	EMMPRIN	5594	682	Gene	Gene	pathways|compound|START_ENTITY expression|nmod|pathways expression|compound|END_ENTITY	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells .
23957201	0	P38	0,3	ERK	38,41	P38	ERK	81649(Tax:10116)	24338(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY important|nsubj|activation important|nmod|activation activation|compound|END_ENTITY	P38 activation is more important than ERK activation in lung_injury induced by prolonged hyperbaric oxygen .
15774115	0	P38	90,93	HSP27	26,31	P38	HSP27	1432	3315	Gene	Gene	-RSB-|compound|START_ENTITY regulated|nmod|-RSB- regulated|nsubjpass|expression expression|compound|END_ENTITY	-LSB- Oxidative stress induced HSP27 expression in human lens epithelial cells is regulated by P38 map kinase -RSB- .
1736522	0	P38	15,18	SP1	75,78	P38	SP1	1432	6667	Gene	Gene	promoter|compound|START_ENTITY requires|nsubj|promoter requires|dobj|region region|appos|site site|compound|END_ENTITY	Parvovirus_H-1 P38 promoter requires the trans-activation region -LRB- tar -RRB- , an SP1 site , and a TATA box for full activity .
18675993	0	P38	12,15	TNF-alpha	44,53	P38	TNF-alpha	1432	7124	Gene	Gene	MAPK|compound|START_ENTITY role|nmod|MAPK role|acl|induced induced|dobj|release release|amod|END_ENTITY	The role of P38 MAPK and PKC in BLP induced TNF-alpha release , apoptosis , and NFkappaB activation in THP-1 monocyte cells .
20646342	0	P38	25,28	TNF-alpha	87,96	P38	TNF-alpha	1432	7124	Gene	Gene	MAPK|compound|START_ENTITY budesonide|nmod|MAPK activation|amod|budesonide Effects|nmod|activation induced|nsubj|Effects induced|nmod|END_ENTITY	Effects of budesonide on P38 MAPK activation , apoptosis and IL-8 secretion , induced by TNF-alpha and Haemophilus_influenzae in human bronchial epithelial cells .
12421638	0	P38	0,3	iNOS	87,91	P38	iNOS	1432	4843	Gene	Gene	kinase|nummod|START_ENTITY inhibitor|nsubj|kinase inhibitor|ccomp|has has|dobj|effect effect|nmod|expression expression|amod|END_ENTITY	P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production .
22155741	0	P38	112,115	iNOS	45,49	P38	iNOS	26416(Tax:10090)	18126(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY suppressing|dobj|activation inhibits|advcl|suppressing inhibits|dobj|up-regulation up-regulation|amod|END_ENTITY	Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264 .7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge .
3130468	0	P38	68,71	synapsin_I	30,40	P38	synapsin I	1432	6853	Gene	Gene	protein|nummod|START_ENTITY END_ENTITY|appos|protein	The synaptic vesicle proteins synapsin_I and synaptophysin -LRB- protein P38 -RRB- are concentrated both in efferent and afferent nerve endings of the skeletal muscle .
19861252	0	P38MAPK	1,8	COX-2	27,32	P38MAPK	COX-2	26416(Tax:10090)	17709(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	-LSB- P38MAPK pathway regulates COX-2 and caspase-3 expression in a mouse model of Parkinson_disease -RSB- .
11834148	0	P38MAPK	21,28	TNFalpha	43,51	P38MAPK	TNFalpha	1432	7124	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Regulative effect of P38MAPK on release of TNFalpha and NO from alveolar macrophages under endotoxin stimulation .
26571038	0	P38_MAPK	148,156	HMGB1	106,111	P38 MAPK	HMGB1	1432	3146	Gene	Gene	Pathway|compound|START_ENTITY Expression|nmod|Pathway Expression|compound|END_ENTITY	The Protective Role of Interleukin-33 in Myocardial_Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38_MAPK Signaling Pathway .
20099714	0	P38_MAP_kinase	0,14	angiotensin_II	59,73	P38 MAP kinase	angiotensin II	1432	183	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	P38_MAP_kinase in valve interstitial cells is activated by angiotensin_II or nitric_oxide / peroxynitrite , but reduced by Toll-like_receptor-2 stimulation .
15155098	0	P38_mitogen-activated_protein_kinase	9,45	P-selectin	63,73	P38 mitogen-activated protein kinase	P-selectin	1432	6403	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Role of P38_mitogen-activated_protein_kinase in expression of P-selectin on human umbilical vein endothelial cells -RSB- .
12679868	0	P38_mitogen-activated_protein_kinase	0,36	TGFbeta1	65,73	P38 mitogen-activated protein kinase	TGFbeta1	1432	4052	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	P38_mitogen-activated_protein_kinase mediates hexosamine-induced TGFbeta1 mRNA expression in human mesangial cells .
11306462	0	P39	126,129	Caspase-3	0,9	P39	Caspase-3	9114	836	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Caspase-3 activation by lysosomal enzymes in cytochrome_c-independent apoptosis in myelodysplastic_syndrome-derived cell line P39 .
21454556	0	P4-ATPase_ATP8A2	139,155	CDC50A	34,40	P4-ATPase ATP8A2	CDC50A	201780	55754	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of the beta-subunit CDC50A in the stable expression , assembly , subcellular localization , and lipid transport activity of the P4-ATPase_ATP8A2 .
10776788	0	P45	82,85	gp36	28,32	P45	gp36	4778	10630	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	HIV-2 transmembrane protein gp36 binds to the putative cellular receptor proteins P45 and P62 .
12642464	0	P450	54,58	Stat1	62,67	P450	Stat1	1555	20846(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice .
7545622	0	P450	50,54	THP_1	58,63	P450	THP 1	1555	2736	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Expression and regulation of aromatase cytochrome P450 in THP_1 human myeloid_leukaemia cells .
19041851	0	P450	78,82	hCMEC/D3	86,94	P450	hCMEC/D3	1555	1735	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells .
9442090	0	P450RAI	6,13	CYP26	15,20	P450RAI	CYP26	13082(Tax:10090)	13082(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Mouse P450RAI -LRB- CYP26 -RRB- expression and retinoic_acid-inducible retinoic_acid metabolism in F9 cells are regulated by retinoic_acid receptor gamma and retinoid_X receptor alpha .
12101034	0	P450RAI-2	48,57	CYP26B1	39,46	P450RAI-2	CYP26B1	56603	56603	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of cytochrome CYP26B1 -LRB- P450RAI-2 -RRB- in human cephalic tissues .
12208671	0	P450_aromatase	59,73	Insulin	0,7	P450 aromatase	Insulin	281740(Tax:9913)	280829(Tax:9913)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	Insulin and IGF-I are necessary for FSH-induced cytochrome P450_aromatase but not cytochrome P450 side-chain cleavage gene expression in oestrogenic bovine granulosa cells in vitro .
18930820	0	P450_reductase	0,14	cytochrome_P450	51,66	P450 reductase	cytochrome P450	33883(Tax:7227)	35635(Tax:7227)	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	P450_reductase and cytochrome_b5 interactions with cytochrome_P450 : effects on house fly CYP6A1 catalysis .
16506070	0	P450arom	17,25	Dmrt-1	49,55	P450arom	Dmrt-1	1588	1761	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|genes genes|compound|END_ENTITY	Up-regulation of P450arom and down-regulation of Dmrt-1 genes in the temperature-dependent sex reversal from genetic males to phenotypic females in a salamander .
14580722	0	P450arom	43,51	WT1	0,3	P450arom	WT1	1588	7490	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells .
8784078	0	P450c11	43,50	CYP11B	35,41	P450c11	CYP11B	1584	1584	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	The human genome contains only two CYP11B -LRB- P450c11 -RRB- genes .
17434514	0	P450c17	23,30	CYP17	32,37	P450c17	CYP17	1586	1586	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elevated expression of P450c17 -LRB- CYP17 -RRB- during testicular formation in the frog .
21074531	0	P450c17	84,91	CYP17A1	107,114	P450c17	CYP17A1	281739(Tax:9913)	281739(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The bovine genome contains three differentially methylated paralogous copies of the P450c17 encoding gene -LRB- CYP17A1 -RRB- .
1937474	0	P450c21B	64,72	steroid_21-hydroxylase	38,60	P450c21B	steroid 21-hydroxylase	1589	1589	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Substitution of Ile-172_to_Asn in the steroid_21-hydroxylase B -LRB- P450c21B -RRB- gene in a Finnish patient with the simple virilizing form of congenital_adrenal_hyperplasia .
2901225	0	P450pcn1	23,31	COL1A2	83,89	P450pcn1	COL1A2	1576	1278	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	The gene CYP3 encoding P450pcn1 -LRB- nifedipine_oxidase -RRB- is tightly linked to the gene COL1A2 encoding collagen type 1 alpha on 7q21-q22 .1 .
8394339	0	P450scc	40,47	CYP11A	32,38	P450scc	CYP11A	338048(Tax:9913)	338048(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of expression of the CYP11A -LRB- P450scc -RRB- gene in bovine ovarian luteal cells by forskolin and phorbol_esters .
8119986	0	P450scc	89,96	CYP11A1	80,87	P450scc	CYP11A1	1583	1583	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Actions of two different cAMP-responsive sequences and an enhancer of the human CYP11A1 -LRB- P450scc -RRB- gene in adrenal Y1 and placental JEG-3 cells .
16730372	0	P450scc	39,46	MGR	13,16	P450scc	MGR	1583	317773	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Human LBP-32 / MGR is a repressor of the P450scc in human choriocarcinoma cell line JEG-3 .
16574160	0	P450scc	102,109	StAR	155,159	P450scc	StAR	29680(Tax:10116)	25557(Tax:10116)	Gene	Gene	side-chain-cleavage|appos|START_ENTITY side-chain-cleavage|appos|END_ENTITY	Steroidogenic_impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage -LRB- P450scc -RRB- and steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- during experimental nephrotic_syndrome .
18001058	0	P450scc	83,90	StAR	32,36	P450scc	StAR	1583	6770	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Steroidogenic acute regulatory -LRB- StAR -RRB- protein and cholesterol side-chain cleavage -LRB- P450scc -RRB- as molecular and cellular targets for 17alpha-ethynylestradiol in salmon previtellogenic oocytes .
9468515	0	P450scc	24,31	steroidogenic_factor_1	40,62	P450scc	steroidogenic factor 1	1583	2516	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of the human P450scc gene by steroidogenic_factor_1 is mediated by CBP/p300 .
18508888	0	P49	73,76	P35	102,105	P49	P35	5557	3592	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Reactive-site cleavage residues confer target specificity to baculovirus P49 , a dimeric member of the P35 family of caspase inhibitors .
26966067	0	P4HA1	103,108	prolyl_4-hydroxylase_subunit_alpha-1	65,101	P4HA1	prolyl 4-hydroxylase subunit alpha-1	5033	5033	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl_4-hydroxylase_subunit_alpha-1 -LRB- P4HA1 -RRB- mRNA .
11035101	0	P50	22,25	C-reactive_protein	52,70	P50	C-reactive protein	4790	1401	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	The Rel family member P50 mediates cytokine-induced C-reactive_protein expression by a novel mechanism .
22073260	0	P50	0,3	PCNA	132,136	P50	PCNA	4790	5111	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	P50 , the small subunit of DNA_polymerase_delta , is required for mediation of the interaction of polymerase delta subassemblies with PCNA .
12269832	0	P52rIPK	0,7	P58IPK	44,50	P52rIPK	P58IPK	5612	5611	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress .
26286430	0	P53	42,45	BAX	56,59	P53	BAX	7157	581	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|Expression Expression|compound|END_ENTITY	Effect of Cnidium_Lactone on Serum Mutant P53 and BCL-2 / BAX Expression in Human Prostate_Cancer Cells PC-3 Tumor-Bearing BALB/C Nude Mouse Model .
25297597	0	P53	28,31	BCL6	17,21	P53	BCL6	7157	604	Gene	Gene	abnormalities|appos|START_ENTITY abnormalities|compound|END_ENTITY	-LSB- Significance of BCL6 , MYC , P53 genes abnormalities for the prognosis of diffuse_large_B-cell_lymphoma -RSB- .
11351299	0	P53	83,86	Bax	0,3	P53	Bax	7157	581	Gene	Gene	dysregulation|nmod|START_ENTITY thyroid_tumours|dep|dysregulation expression|nmod|thyroid_tumours expression|compound|END_ENTITY	Bax expression in benign and malignant thyroid_tumours : dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid_carcinoma .
11351299	0	P53	83,86	Bax	113,116	P53	Bax	7157	581	Gene	Gene	dysregulation|nmod|START_ENTITY thyroid_tumours|dep|dysregulation expression|nmod|thyroid_tumours associated|nsubjpass|expression associated|nmod|END_ENTITY	Bax expression in benign and malignant thyroid_tumours : dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid_carcinoma .
18652568	0	P53	71,74	Bcl-2	76,81	P53	Bcl-2	22060(Tax:10090)	12043(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY induces|nmod|modulation -LSB-|ccomp|induces -LSB-|nsubj|activation activation|amod|END_ENTITY	Inositol_hexaphosphate induces apoptosis by coordinative modulation of P53 , Bcl-2 and sequential activation of caspases in 7,12 dimethylbenz -LSB- a -RSB- anthracene exposed mouse epidermis .
21544463	0	P53	0,3	Bcl-2	5,10	P53	Bcl-2	7157	596	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	P53 , Bcl-2 expression and cell proliferation in benign breast lesions .
17487067	0	P53	47,50	Bcl2	57,61	P53	Bcl2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	PCNA|compound|START_ENTITY PCNA|appos|END_ENTITY	Differential protection and transactivation of P53 , P21 , Bcl2 , PCNA , cyclin_G , and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin .
24147952	0	P53	55,58	C-myc	87,92	P53	C-myc	7157	4609	Gene	Gene	Survivn|compound|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
11812190	0	P53	0,3	CD58	43,47	P53	CD58	7157	965	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	P53 possibly upregulates the expression of CD58 -LRB- LFA-3 -RRB- and CD59 -LRB- MIRL -RRB- .
18498065	0	P53	0,3	CD95	5,9	P53	CD95	7157	355	Gene	Gene	START_ENTITY|appos|pathways pathways|compound|END_ENTITY	P53 , CD95 , cathepsin and survivin pathways in Fuchs ' _ dystrophy and pseudophakic_bullous_keratopathy corneas .
23729286	0	P53	34,37	CD95	50,54	P53	CD95	7157	355	Gene	Gene	FAS|compound|START_ENTITY FAS|appos|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
23907425	0	P53	163,166	COX-2	11,16	P53	COX-2	7157	5743	Gene	Gene	gene|compound|START_ENTITY downregulation|nmod|gene associated|nmod|downregulation associated|nsubjpass|Changes Changes|nmod|factors factors|amod|END_ENTITY	Changes in COX-2 and oxidative damage factors during differentiation of human mesenchymal stem cells to hepatocyte-like cells is associated with downregulation of P53 gene .
16005638	0	P53	23,26	CXCR_4	39,45	P53	CXCR 4	7157	7852	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of neuronal P53 activity by CXCR_4 .
26884717	0	P53	50,53	Cyclosporine_A	0,14	P53	Cyclosporine A	22060(Tax:10090)	71991(Tax:10090)	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Cyclosporine_A Suppressed Glucose_Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition .
25004291	0	P53	14,17	E-cadherin	19,29	P53	E-cadherin	7157	999	Gene	Gene	Cox-2|compound|START_ENTITY Cox-2|dep|END_ENTITY	Evaluation of P53 , E-cadherin , Cox-2 , and EGFR protein imunnoexpression on prognostic of resected gallbladder_carcinoma .
19165235	0	P53	0,3	EGFR	56,60	P53	EGFR	7157	1956	Gene	Gene	expression|compound|START_ENTITY contribute|nsubj|expression contribute|nmod|inhibition inhibition|nmod|downstream downstream|compound|END_ENTITY	P53 and PTEN expression contribute to the inhibition of EGFR downstream signaling pathway by cetuximab .
23755891	0	P53	0,3	EGFR	115,119	P53	EGFR	7157	1956	Gene	Gene	mutations|nummod|START_ENTITY upregulate|nsubj|mutations upregulate|dobj|recycling recycling|nmod|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	P53 mutations in triple_negative_breast_cancer upregulate endosomal recycling of epidermal_growth_factor_receptor -LRB- EGFR -RRB- increasing its oncogenic potency .
21660463	0	P53	33,36	ERK	49,52	P53	ERK	7157	5594	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	ARF triggers cell G1 arrest by a P53 independent ERK pathway .
19427386	0	P53	0,3	FOXO3a	57,63	P53	FOXO3a	7157	2309	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	P53 negatively regulates the transcriptional activity of FOXO3a under oxidative stress .
26884717	0	P53	50,53	Glucose_Oxidase	26,41	P53	Glucose Oxidase	22060(Tax:10090)	15112(Tax:10090)	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	Cyclosporine_A Suppressed Glucose_Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition .
19170058	0	P53	57,60	IFI16	0,5	P53	IFI16	7157	3428	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters .
24147952	0	P53	55,58	IMP1	60,64	P53	IMP1	7157	10642	Gene	Gene	Survivn|compound|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
14745729	0	P53	0,3	K-Ras	12,17	P53	K-Ras	7157	3845	Gene	Gene	N|compound|START_ENTITY N|dep|END_ENTITY	P53 , N - and K-Ras , and beta-catenin gene mutations and prognostic factors in nasal NK/T-cell _ lymphoma from Hokkaido , Japan .
26168827	0	P53	80,83	K-ras	73,78	P53	K-ras	7157	3845	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	Evaluation of Intraductal Ultrasonography , Endoscopic Brush Cytology and K-ras , P53 Gene Mutation in the Early Diagnosis of Malignant Bile_Duct_Stricture .
11400116	0	P53	30,33	MDM2	96,100	P53	MDM2	7157	4193	Gene	Gene	immunoreactivity|nummod|START_ENTITY distribution|nmod|immunoreactivity correlates|nsubj|distribution correlates|nmod|expression expression|compound|END_ENTITY	Heterogeneous distribution of P53 immunoreactivity in human lung_adenocarcinoma correlates with MDM2 protein expression , rather than with P53 gene mutation .
16696307	0	P53	0,3	MDM2	36,40	P53	MDM2	7157	4193	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	P53 gene mutation and expression of MDM2 , P53 , P16 protein and their relationship in human glioma .
17120736	0	P53	0,3	MDM2	54,58	P53	MDM2	7157	4193	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|blockage blockage|nmod|END_ENTITY	P53 regulation of leukemia cells with the blockage of MDM2 by antisense oligonucleotides .
20156327	0	P53	73,76	MDM2	93,97	P53	MDM2	7157	4193	Gene	Gene	R72P|nmod|START_ENTITY R72P|nmod|END_ENTITY	Have the roles of two functional polymorphisms in breast_cancer , R72P in P53 and MDM2-309 in MDM2 , become clearer ?
23084521	0	P53	44,47	MDM2	14,18	P53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY RG7112|nmod|pathway RG7112|compound|END_ENTITY	Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified , well-differentiated or dedifferentiated liposarcoma : an exploratory proof-of-mechanism study .
19160491	0	P53	0,3	Mdm2	43,47	P53	Mdm2	7157	4193	Gene	Gene	mRNA|compound|START_ENTITY controls|nsubj|mRNA controls|nmod|functions functions|amod|END_ENTITY	P53 mRNA controls p53 activity by managing Mdm2 functions .
19954744	0	P53	82,85	Mdm2	0,4	P53	Mdm2	7157	4193	Gene	Gene	mutations|compound|START_ENTITY frequency|nmod|mutations displays|dobj|frequency displays|nsubj|allele allele|compound|END_ENTITY	Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular_carcinoma .
12669312	0	P53	0,3	Nm23-H1	53,60	P53	Nm23-H1	7157	4830	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	P53 is a regulator of the metastasis suppressor gene Nm23-H1 .
24147952	0	P53	55,58	P16	66,69	P53	P16	7157	1029	Gene	Gene	Survivn|compound|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
25890228	0	P53	42,45	P16	47,50	P53	P16	7157	1029	Gene	Gene	mutant|nummod|START_ENTITY mutant|nummod|END_ENTITY	Clinical outcome and expression of mutant P53 , P16 , and Smad4 in lung_adenocarcinoma : a prospective study .
23729286	0	P53	34,37	P16INK4A	57,65	P53	P16INK4A	7157	1029	Gene	Gene	FAS|compound|START_ENTITY FAS|appos|L1 L1|compound|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
11700890	0	P53	61,64	P21	0,3	P53	P21	7157	1026	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|amod|END_ENTITY	P21 -LRB- WAF1 -RRB- expression in colorectal_cancer : correlation with P53 and cyclin_D1 expression , clinicopathological parameters and prognosis .
17487067	0	P53	47,50	P21	52,55	P53	P21	301300(Tax:10116)	24525(Tax:10116)	Gene	Gene	PCNA|compound|START_ENTITY PCNA|appos|END_ENTITY	Differential protection and transactivation of P53 , P21 , Bcl2 , PCNA , cyclin_G , and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin .
8732090	0	P53	37,40	P21	32,35	P53	P21	7157	644914	Gene	Gene	Detection|appos|START_ENTITY Detection|nmod|expression expression|nmod|END_ENTITY	-LSB- Detection of the expression of P21 , P53 , P185 proteins and the mutation of ras , p53 genes in colorectal_adenoma_and_carcinoma -RSB- .
24210115	0	P53	87,90	P33	41,44	P53	P33	7157	3621	Gene	Gene	protein|compound|START_ENTITY interacts|nmod|protein interacts|nsubj|Ac92 Ac92|appos|END_ENTITY	The baculovirus sulfhydryl oxidase Ac92 -LRB- P33 -RRB- interacts with the Spodoptera frugiperda P53 protein and oxidizes it in vitro .
24147952	0	P53	55,58	P62	82,85	P53	P62	7157	23636	Gene	Gene	Survivn|compound|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
11252895	0	P53	13,16	P63	0,3	P53	P63	7157	8626	Gene	Gene	mimics|compound|START_ENTITY END_ENTITY|dep|mimics	P63 and P73 : P53 mimics , menaces and more .
15225615	0	P53	2,5	PIG11	19,24	P53	PIG11	7157	9537	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A P53 target gene , PIG11 , contributes to chemosensitivity of cells to arsenic_trioxide .
24908061	0	P53	77,80	PIK3CA	36,42	P53	PIK3CA	7157	5290	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	A single nucleotide polymorphism in PIK3CA gene is inversely associated with P53 protein expression in breast_cancer .
26446704	0	P53	102,105	PKR	10,13	P53	PKR	7157	5610	Gene	Gene	stabilization|nmod|START_ENTITY inhibits|nmod|stabilization inhibits|nsubj|END_ENTITY	Activated PKR inhibits pancreatic b-cell proliferation through sumoylation-dependent stabilization of P53 .
20807096	0	P53	54,57	PTEN	0,4	P53	PTEN	7157	5728	Gene	Gene	suppressor|compound|START_ENTITY plays|nmod|suppressor plays|nsubj|suppressor suppressor|compound|END_ENTITY	PTEN tumor suppressor plays less prognostic role than P53 tumor suppressor in diffuse_large_B-cell_lymphoma .
23729286	0	P53	34,37	PTEN	39,43	P53	PTEN	7157	5728	Gene	Gene	FAS|compound|START_ENTITY FAS|appos|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
16473854	0	P53	106,109	Parp-1	31,37	P53	Parp-1	7157	142	Gene	Gene	topoisomerase|nmod|START_ENTITY topoisomerase|nsubj|antagonizes antagonizes|amod|polymerase-1 polymerase-1|dep|END_ENTITY	Poly -LRB- ADP-RIBOSE -RRB- _ polymerase-1 -LRB- Parp-1 -RRB- antagonizes topoisomerase I-dependent recombination stimulation by P53 .
16416012	0	P53	0,3	VEGF	31,35	P53	VEGF	7157	7422	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	P53 correlates positively with VEGF in preoperative sera of colorectal_cancer patients .
20076865	0	P53	35,38	Vascular_Endothelial_Growth_Factor	49,83	P53	Vascular Endothelial Growth Factor	7157	7422	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Immunohistochemical evaluation for P53 and VEGF -LRB- Vascular_Endothelial_Growth_Factor -RRB- is not prognostic for long term survival in end stage esophageal_adenocarcinoma .
11700890	0	P53	61,64	WAF1	5,9	P53	WAF1	7157	1026	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|appos|END_ENTITY	P21 -LRB- WAF1 -RRB- expression in colorectal_cancer : correlation with P53 and cyclin_D1 expression , clinicopathological parameters and prognosis .
11852808	0	P53	53,56	WT1	16,19	P53	WT1	7157	7490	Gene	Gene	proteins|compound|START_ENTITY regulation|nmod|proteins expression|nmod|regulation expression|compound|END_ENTITY	-LSB- Involvement of WT1 gene expression in regulation of P53 and MDM2 proteins function in acute_lymphoblastic_leukemia -RSB- .
10365100	0	P53	63,66	androgen_receptor	21,38	P53	androgen receptor	7157	367	Gene	Gene	mutation|nummod|START_ENTITY associated|nmod|mutation associated|nsubjpass|Amplification Amplification|nmod|gene gene|compound|END_ENTITY	Amplification of the androgen_receptor gene is associated with P53 mutation in hormone-refractory recurrent prostate_cancer .
14993973	0	P53	62,65	bcl-2	66,71	P53	bcl-2	7157	596	Gene	Gene	START_ENTITY|dobj|C-myc C-myc|amod|END_ENTITY	-LSB- Study of apoptosis and expression of apoptotic related genes P53 bcl-2 C-myc in oral_lichen_planus -RSB- .
15792122	0	P53	0,3	bcl-2	5,10	P53	bcl-2	7157	596	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	P53 , bcl-2 and Ki-67 expression in adenoid_cystic_carcinoma_of_the_palate .
25610057	0	P53	0,3	bcl-2	5,10	P53	bcl-2	7157	596	Gene	Gene	START_ENTITY|appos|status status|amod|ki-67 ki-67|amod|END_ENTITY	P53 , bcl-2 , ki-67 li -LRB- labeling index -RRB- status in benign , proliferative , and malignant ovarian surface epithelial_neoplasms .
25821312	0	P53	38,41	bcl-2	43,48	P53	bcl-2	7157	596	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of bleomycin A5 on caspase-3 , P53 , bcl-2 expression and telomerase activity in vascular endothelial cells .
9609655	0	P53	0,3	bcl-2	5,10	P53	bcl-2	7157	596	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	P53 , bcl-2 , and Bax expression in renal_cell_carcinoma .
12297840	0	P53	0,3	beta-catenin	48,60	P53	beta-catenin	7157	1499	Gene	Gene	gene|compound|START_ENTITY gene|dep|mutations mutations|amod|END_ENTITY	P53 gene and Wnt signaling in benign neoplasms : beta-catenin mutations in hepatic adenoma but not in focal_nodular_hyperplasia .
12439747	0	P53	0,3	beta-catenin	37,49	P53	beta-catenin	7157	1499	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|source source|nmod|accumulation accumulation|amod|END_ENTITY	P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells .
16434961	0	P53	0,3	beta-catenin	36,48	P53	beta-catenin	22060(Tax:10090)	12387(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY determine|nsubj|levels determine|nmod|initiation initiation|amod|END_ENTITY	P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells .
15493177	0	P53	0,3	c-erbB-2	5,13	P53	c-erbB-2	7157	2064	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	P53 , c-erbB-2 expression and steroid hormone receptors in breast_carcinoma : correlations with histopathological parameters .
11802993	0	P53	70,73	c-myc	75,80	P53	c-myc	7157	4609	Gene	Gene	START_ENTITY|appos|proteins proteins|amod|END_ENTITY	-LSB- Expression of surviving gene and its relationship with expression of P53 , c-myc , k-ras proteins in non-small-cell lung_cancer -RSB- .
25821312	0	P53	38,41	caspase-3	27,36	P53	caspase-3	7157	836	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of bleomycin A5 on caspase-3 , P53 , bcl-2 expression and telomerase activity in vascular endothelial cells .
24147952	0	P53	55,58	cyclin_B1	71,80	P53	cyclin B1	7157	891	Gene	Gene	Survivn|compound|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
17487067	0	P53	47,50	cyclin_G	69,77	P53	cyclin G	301300(Tax:10116)	25405(Tax:10116)	Gene	Gene	PCNA|compound|START_ENTITY protection|nmod|PCNA END_ENTITY|nsubj|protection	Differential protection and transactivation of P53 , P21 , Bcl2 , PCNA , cyclin_G , and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin .
18758819	0	P53	149,152	epidermal_growth_factor_receptor	42,74	P53	epidermal growth factor receptor	7157	1956	Gene	Gene	antibody|nmod|START_ENTITY antibody|nmod|END_ENTITY	In vitro effect of radiation , antibody to epidermal_growth_factor_receptor and Docetaxel in human head and neck squamous_carcinoma cells with mutant P53 and over-expressed EGFR .
23755891	0	P53	0,3	epidermal_growth_factor_receptor	81,113	P53	epidermal growth factor receptor	7157	1956	Gene	Gene	mutations|nummod|START_ENTITY upregulate|nsubj|mutations upregulate|dobj|recycling recycling|nmod|END_ENTITY	P53 mutations in triple_negative_breast_cancer upregulate endosomal recycling of epidermal_growth_factor_receptor -LRB- EGFR -RRB- increasing its oncogenic potency .
15315159	0	P53	91,94	hypoxia_inducible_factor_1-alpha	18,50	P53	hypoxia inducible factor 1-alpha	7157	3091	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of hypoxia_inducible_factor_1-alpha in lung_cancer and its correlation with P53 and VEGF .
11802993	0	P53	70,73	k-ras	82,87	P53	k-ras	7157	3845	Gene	Gene	START_ENTITY|appos|proteins proteins|amod|END_ENTITY	-LSB- Expression of surviving gene and its relationship with expression of P53 , c-myc , k-ras proteins in non-small-cell lung_cancer -RSB- .
23747308	0	P53	69,72	miR-150	0,7	P53	miR-150	7157	406942	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-150 promotes the proliferation of lung_cancer cells by targeting P53 .
12839966	0	P53	0,3	mitochondrial_transcription_factor_A	30,66	P53	mitochondrial transcription factor A	7157	7019	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	P53 physically interacts with mitochondrial_transcription_factor_A and differentially regulates binding to damaged DNA .
23516888	0	P53	15,18	p14	39,42	P53	p14	7157	11102	Gene	Gene	c-Myc|compound|START_ENTITY Expression|nmod|c-Myc END_ENTITY|nsubj|Expression	-LSB- Expression of P53 , NPM1 , Kras , c-Myc , p14 -LRB- ARF -RRB- genes in blood cells of cancer patients before and after radiation therapy -RSB- .
12781424	0	P53	0,3	p21	81,84	P53	p21	7157	1026	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|xcomp|alter alter|nmod|expression expression|nmod|END_ENTITY	P53 -LRB- codon 72 -RRB- and P21 -LRB- codon 31 -RRB- polymorphisms alter in vivo mRNA expression of p21 .
11480026	0	P53	51,54	p53	32,35	P53	p53	7157	7157	Gene	Gene	staining|dep|START_ENTITY staining|compound|END_ENTITY	-LSB- A study on the significance of p53 gene mutation , P53 protein positive staining and PCNA staining -RSB- .
19690760	0	P53	0,3	p63	5,8	P53	p63	7157	8626	Gene	Gene	START_ENTITY|appos|assessment assessment|amod|END_ENTITY	P53 , p63 and Ki-67 assessment in HPV-induced cervical neoplasia .
23959424	0	P53	41,44	sestrin-2	16,25	P53	sestrin-2	7157	83667	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of sestrin-2 expression via P53 protects against 1-methyl-4-phenylpyridinium -LRB- MPP + -RRB- neurotoxicity .
19159630	0	P53/P21	38,45	RUNX_3	67,73	P53/P21	RUNX 3	7157;644914	864	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of activation of P53/P21 and demethylation of RUNX_3 in the cytotoxicity against Lovo cells induced by 5-Aza-2 ' - deoxycytidine .
11920641	0	P53R2	36,41	p53	62,65	P53R2	p53	50484	7157	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	Expression and mutation analyses of P53R2 , a newly identified p53 target for DNA repair in human gastric_carcinoma .
16619496	0	P53R2	0,5	p53	7,10	P53R2	p53	50484	7157	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	P53R2 , p53 inducible ribonucleotide reductase gene , correlated with tumor progression of non-small cell lung_cancer .
24507679	0	P53_and_telomerase	16,34	VEGF	10,14	P53 and telomerase	VEGF	7157	7422	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of VEGF , P53_and_telomerase on angiogenesis of gastric_carcinoma tissue .
10532532	0	P55	48,51	P75	66,69	P55	P75	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	TNFR-I|appos|START_ENTITY TNFR-I|appos|END_ENTITY	Role of tumor necrosis factor receptors TNFR-I -LRB- P55 -RRB- and TNFR-II -LRB- P75 -RRB- in corneal transplantation .
2822968	0	P55	4,7	vimentin	48,56	P55	vimentin	347376	7431	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nsubj|protein	The P55 protein affected by v-mos expression is vimentin .
12269832	0	P58IPK	44,50	P52rIPK	0,7	P58IPK	P52rIPK	5611	5612	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	P52rIPK regulates the molecular cochaperone P58IPK to mediate control of the RNA-dependent protein kinase in response to cytoplasmic stress .
9447982	0	P58IPK	67,73	P52rIPK	114,121	P58IPK	P52rIPK	5611	5612	Gene	Gene	modulation|nmod|START_ENTITY function|nsubj|modulation function|nmod|protein protein|appos|END_ENTITY	Regulation of interferon-induced protein kinase PKR : modulation of P58IPK inhibitory function by a novel protein , P52rIPK .
8990167	0	P58IPK	56,62	PKR	90,93	P58IPK	PKR	5611	5610	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	The molecular chaperone hsp40 regulates the activity of P58IPK , the cellular inhibitor of PKR .
8990167	0	P58IPK	56,62	hsp40	24,29	P58IPK	hsp40	5611	171221	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The molecular chaperone hsp40 regulates the activity of P58IPK , the cellular inhibitor of PKR .
1310388	0	P60	132,135	tumor_necrosis_factor	62,83	P60	tumor necrosis factor	7984	7124	Gene	Gene	forms|nmod|START_ENTITY Inhibition|nmod|forms Inhibition|nmod|END_ENTITY	Inhibition of ligand binding and antiproliferative effects of tumor_necrosis_factor and lymphotoxin by soluble forms of recombinant P60 and P80 receptors .
24147952	0	P62	82,85	C-myc	87,92	P62	C-myc	23636	4609	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	P62	82,85	IMP1	60,64	P62	IMP1	23636	10642	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	P62	82,85	P16	66,69	P62	P16	23636	1029	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	P62	82,85	P53	55,58	P62	P53	23636	7157	Gene	Gene	Survivn|appos|START_ENTITY Survivn|compound|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	P62	82,85	cyclin_B1	71,80	P62	cyclin B1	23636	891	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
17002577	0	P62	93,96	sequestosome_1	78,92	P62	sequestosome 1	8878	8878	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Canine_distemper_virus induces human osteoclastogenesis through NF-kappaB and sequestosome_1 / P62 activation .
18708633	0	P63	8,11	CKAP4	13,18	P63	CKAP4	10970	10970	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of P63 -LRB- CKAP4 -RRB- in binding of surfactant_protein-A to type II pneumocytes .
11252895	0	P63	0,3	P53	13,16	P63	P53	8626	7157	Gene	Gene	START_ENTITY|dep|mimics mimics|compound|END_ENTITY	P63 and P73 : P53 mimics , menaces and more .
20054143	0	P63	0,3	SP-A	18,22	P63	SP-A	216197(Tax:10090)	20387(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	P63 -LRB- CKAP4 -RRB- as an SP-A receptor : implications for surfactant turnover .
22286145	0	P65	72,75	NFkB	67,71	P65	NFkB	25716(Tax:10116)	309165(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Ischemia-reperfusion_injury in rat steatotic liver is dependent on NFkB P65 activation .
15094067	0	P66	0,3	MAPKAP_kinase_2	25,40	P66	MAPKAP kinase 2	10714	9261	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	P66 -LRB- ShcA -RRB- interacts with MAPKAP_kinase_2 and regulates its activity .
21778425	0	P66Shc	14,20	SIRT1	35,40	P66Shc	SIRT1	20416(Tax:10090)	93759(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial_dysfunction .
11536043	0	P73	0,3	p53	130,133	P73	p53	7161	7157	Gene	Gene	expression|nummod|START_ENTITY expression|dep|role role|nmod|concert concert|nmod|END_ENTITY	P73 expression in basal layers of head_and_neck_squamous_epithelium : a role in differentiation and carcinogenesis in concert with p53 and p63 ?
15849742	0	P73	0,3	p53	26,29	P73	p53	7161	7157	Gene	Gene	replaces|nsubj|START_ENTITY replaces|dobj|END_ENTITY	P73 functionally replaces p53 in Adriamycin-treated , p53-deficient breast_cancer cells .
1420599	0	P75	151,154	IL-2	155,159	P75	IL-2	3560	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Tumor recognition and lytic competence of IL-2-activated lymphocytes : regulation of both antibody-independent and - dependent cellular cytotoxicity via P75 IL-2 receptor .
12422217	0	P75	0,3	Nogo_receptor	23,36	P75	Nogo receptor	18053(Tax:10090)	65079(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	P75 interacts with the Nogo_receptor as a co-receptor for Nogo , MAG and OMgp .
10532532	0	P75	66,69	P55	48,51	P75	P55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	TNFR-I|appos|START_ENTITY TNFR-I|appos|END_ENTITY	Role of tumor necrosis factor receptors TNFR-I -LRB- P55 -RRB- and TNFR-II -LRB- P75 -RRB- in corneal transplantation .
14621914	0	P75	43,46	interleukin_2_receptor_b	11,35	P75	interleukin 2 receptor b	3560	3558	Gene	Gene	chain|appos|START_ENTITY chain|amod|END_ENTITY	Effects of interleukin_2_receptor_b chain -LRB- P75 -RRB- - specific monoclonal antibody on the generation of cytotoxic T lymphocytes and suppressor T cells in mixed lymphocyte culture .
1912477	0	P80	22,25	CD44	16,20	P80	CD44	8161	960	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of CD44 -LRB- P80 -RRB- on the external surface of a human astrocytoma cell .
16403586	0	PA-1	125,129	PA-1	55,59	PA-1	PA-1	67278(Tax:10090)	67278(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and purification of a fusion-typed pediocin PA-1 in Escherichia_coli and recovery of biologically active pediocin PA-1 .
16403586	0	PA-1	55,59	PA-1	125,129	PA-1	PA-1	67278(Tax:10090)	67278(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and purification of a fusion-typed pediocin PA-1 in Escherichia_coli and recovery of biologically active pediocin PA-1 .
10342830	0	PA-1	112,116	activin	50,57	PA-1	activin	79447	83729	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Differential response to exogenous and endogenous activin in a human ovarian_teratocarcinoma-derived cell line -LRB- PA-1 -RRB- : regulation by cell surface follistatin .
10682683	0	PA2G4	19,24	EBP1	26,30	PA2G4	EBP1	5036	5036	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Interaction of the PA2G4 -LRB- EBP1 -RRB- protein with ErbB-3 and regulation of this binding by heregulin .
10682683	0	PA2G4	19,24	ErbB-3	45,51	PA2G4	ErbB-3	5036	2065	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Interaction of the PA2G4 -LRB- EBP1 -RRB- protein with ErbB-3 and regulation of this binding by heregulin .
22402495	0	PAB-1	62,67	AIN-1	41,46	PAB-1	AIN-1	172920(Tax:6239)	181719(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Caenorhabditis_elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes .
16834569	0	PABP	74,78	AUF1	26,30	PABP	AUF1	26986	3184	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The ARE-associated factor AUF1 binds poly -LRB- A -RRB- in vitro in competition with PABP .
17471234	0	PAC1	0,4	E2F-1	41,46	PAC1	E2F-1	1844	1869	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	PAC1 is a direct transcription target of E2F-1 in apoptotic signaling .
26336928	0	PAC1	72,76	GHRELIN	109,116	PAC1	GHRELIN	11517(Tax:10090)	58991(Tax:10090)	Gene	Gene	RECEPTOR|compound|START_ENTITY RECEPTOR|nmod|END_ENTITY	PACAP INTRAPERITONEAL TREATMENT SUPPRESSES APPETITE AND FOOD INTAKE VIA PAC1 RECEPTOR IN MICE , BY INHIBITING GHRELIN , AND INCREASING GLP-1 AND LEPTIN .
25658447	0	PAC1	21,25	PACAP	0,5	PAC1	PACAP	117	116	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	PACAP Interacts with PAC1 Receptors to Induce Tissue_Plasminogen_Activator -LRB- tPA -RRB- Expression and Activity in Schwann Cell-Like Cultures .
10366751	0	PAC1-R	17,23	PACAP-type_I_receptor	25,46	PAC1-R	PACAP-type I receptor	117	117	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Induction of the PAC1-R -LRB- PACAP-type_I_receptor -RRB- gene by p53 and Zac .
16888229	0	PAC1-R	16,22	PACAP_receptor	0,14	PAC1-R	PACAP receptor	24167(Tax:10116)	24167(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	PACAP_receptor -LRB- PAC1-R -RRB- expression in rat and rhesus_monkey thymus .
21539889	0	PAC1R	112,117	PACAP	74,79	PAC1R	PACAP	24167(Tax:10116)	24166(Tax:10116)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Stimulatory effect of pituitary adenylate-cyclase activating polypeptide -LRB- PACAP -RRB- and its PACAP_type_I_receptor -LRB- PAC1R -RRB- on prolactin synthesis in rat pituitary somatolactotroph GH3 cells .
17900711	0	PAC1R	103,108	pituitary_adenylate_cyclase-activating_polypeptide-specific_receptor	33,101	PAC1R	pituitary adenylate cyclase-activating polypeptide-specific receptor	117	117	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and localization of pituitary_adenylate_cyclase-activating_polypeptide-specific_receptor -LRB- PAC1R -RRB- in the rostral migratory stream of the infant mouse brain .
10960361	0	PACAP	37,42	CCK	11,14	PACAP	CCK	116	885	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Control Control|nmod|gene gene|compound|END_ENTITY	Control of CCK gene transcription by PACAP in STC-1 cells .
12383860	0	PACAP	0,5	CD11b	33,38	PACAP	CD11b	116	3684	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	PACAP enhances the expression of CD11b , CD66b and CD63 in human neutrophils .
15570170	0	PACAP	31,36	CD4	70,73	PACAP	CD4	11516(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	Restoration of axotomy-induced PACAP gene induction in SCID mice with CD4 + T-lymphocytes .
24210136	0	PACAP	25,30	CGRP	0,4	PACAP	CGRP	116	796	Gene	Gene	play|nsubj|START_ENTITY END_ENTITY|parataxis|play	CGRP and migraine : could PACAP play a role too ?
25463029	0	PACAP	37,42	CGRP	16,20	PACAP	CGRP	24166(Tax:10116)	24241(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of CGRP , CGRP receptor , PACAP and glutamate in trigeminal_ganglion .
25463029	0	PACAP	37,42	CGRP	22,26	PACAP	CGRP	24166(Tax:10116)	24241(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Localization Localization|appos|receptor receptor|compound|END_ENTITY	Localization of CGRP , CGRP receptor , PACAP and glutamate in trigeminal_ganglion .
9178350	0	PACAP	76,81	CGRP	120,124	PACAP	CGRP	24166(Tax:10116)	24241(Tax:10116)	Gene	Gene	pituitary_adenylate_cyclase_activating_peptide|appos|START_ENTITY pituitary_adenylate_cyclase_activating_peptide|appos|END_ENTITY	Capsaicin-evoked release of pituitary_adenylate_cyclase_activating_peptide -LRB- PACAP -RRB- and calcitonin_gene-related_peptide -LRB- CGRP -RRB- from rat spinal cord in vivo .
19238593	0	PACAP	0,5	DREAM	19,24	PACAP	DREAM	116	30818	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	PACAP signaling to DREAM : a cAMP-dependent pathway that regulates cortical astrogliogenesis .
15046862	0	PACAP	0,5	ERK1/2	57,63	PACAP	ERK1/2	24166(Tax:10116)	50689;116590	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	PACAP activates Rac1 and synergizes with NGF to activate ERK1/2 , thereby inducing neurite outgrowth in PC12 cells .
25168001	0	PACAP	0,5	NOS1	66,70	PACAP	NOS1	116	4842	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting .
25658447	0	PACAP	0,5	PAC1	21,25	PACAP	PAC1	116	117	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	PACAP Interacts with PAC1 Receptors to Induce Tissue_Plasminogen_Activator -LRB- tPA -RRB- Expression and Activity in Schwann Cell-Like Cultures .
21539889	0	PACAP	74,79	PAC1R	112,117	PACAP	PAC1R	24166(Tax:10116)	24167(Tax:10116)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Stimulatory effect of pituitary adenylate-cyclase activating polypeptide -LRB- PACAP -RRB- and its PACAP_type_I_receptor -LRB- PAC1R -RRB- on prolactin synthesis in rat pituitary somatolactotroph GH3 cells .
19211999	0	PACAP	28,33	PEDF	11,15	PACAP	PEDF	24166(Tax:10116)	287526(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of PEDF and VEGF on PACAP - / VIP-induced cAMP formation in rat brain derived astrocyte cultures .
9733069	0	PACAP	52,57	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	PACAP	Pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- expression in sympathetic preganglionic projection neurons to the superior cervical ganglion .
15046862	0	PACAP	0,5	Rac1	16,20	PACAP	Rac1	24166(Tax:10116)	363875(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	PACAP activates Rac1 and synergizes with NGF to activate ERK1/2 , thereby inducing neurite outgrowth in PC12 cells .
10960361	0	PACAP	37,42	STC-1	46,51	PACAP	STC-1	116	6781	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Control of CCK gene transcription by PACAP in STC-1 cells .
21975601	0	PACAP	18,23	STC1	0,4	PACAP	STC1	24166(Tax:10116)	81801(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons .
8923513	0	PACAP	60,65	VIP	0,3	PACAP	VIP	116	7432	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|compound|END_ENTITY	VIP and pituitary adenylate cyclase activating polypeptide -LRB- PACAP -RRB- have an antiproliferative effect on the T98G human glioblastoma cell line through interaction with VIP2 receptor .
20920539	0	PACAP	0,5	apolipoprotein_D	37,53	PACAP	apolipoprotein D	11516(Tax:10090)	11815(Tax:10090)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	PACAP up-regulates the expression of apolipoprotein_D in 3T3-L1 adipocytes .
8660319	0	PACAP	0,5	c-Fos	34,39	PACAP	c-Fos	24166(Tax:10116)	314322(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|nmod|END_ENTITY	PACAP stimulates transcription of c-Fos and c-Jun and activates the AP-1 transcription factor in rat pancreatic_carcinoma cells .
12088867	0	PACAP	14,19	follicle-stimulating_hormone-beta	43,76	PACAP	follicle-stimulating hormone-beta	24166(Tax:10116)	25447(Tax:10116)	Gene	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Evidence that PACAP and GnRH down-regulate follicle-stimulating_hormone-beta mRNA levels by stimulating follistatin gene expression : effects on folliculostellate cells , gonadotrophs and LbetaT2 gonadotroph cells .
16888221	0	PACAP	0,5	interleukin-6	32,45	PACAP	interleukin-6	24166(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|cells cells|amod|END_ENTITY	PACAP stimulates the release of interleukin-6 in cultured rat M ller cells .
1321043	0	PACAP	93,98	pituitary_adenylate-cyclase-activating-peptide	45,91	PACAP	pituitary adenylate-cyclase-activating-peptide	116	116	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Structural requirements for the occupancy of pituitary_adenylate-cyclase-activating-peptide -LRB- PACAP -RRB- receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes .
15721490	0	PACAP	56,61	pituitary_adenylate_cyclase-activating_peptide	8,54	PACAP	pituitary adenylate cyclase-activating peptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of pituitary_adenylate_cyclase-activating_peptide -LRB- PACAP -RRB- in the cyclic recruitment of immature follicles in the rat ovary .
10389149	0	PACAP	74,79	pituitary_adenylate_cyclase-activating_polypeptide	22,72	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Stimulatory effect of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the hypothalamus and cerebral cortex of four avians and rat .
10441752	0	PACAP	89,94	pituitary_adenylate_cyclase-activating_polypeptide	37,87	PACAP	pituitary adenylate cyclase-activating polypeptide	116	116	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization and localization of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- binding sites in the brain of the frog Rana ridibunda .
10909177	0	PACAP	63,68	pituitary_adenylate_cyclase-activating_polypeptide	11,61	PACAP	pituitary adenylate cyclase-activating polypeptide	101800734	101800734	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the duck and goose brain .
12951407	0	PACAP	115,120	pituitary_adenylate_cyclase-activating_polypeptide	63,113	PACAP	pituitary adenylate cyclase-activating polypeptide	116	116	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	Regional concentration and chromatographic characterization of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the brain of the bullfrog , Rana catesbeiana .
1331206	0	PACAP	112,117	pituitary_adenylate_cyclase-activating_polypeptide	60,110	PACAP	pituitary adenylate cyclase-activating polypeptide	116	116	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Immunohistochemical distribution and biological activity of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the central nervous system of the frog Rana ridibunda .
16124881	0	PACAP	143,148	pituitary_adenylate_cyclase-activating_polypeptide	91,141	PACAP	pituitary adenylate cyclase-activating polypeptide	11516(Tax:10090)	11516(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- withdrawal masks gene expression differences in the study of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- activation of primary neural stem cell proliferation .
18313848	0	PACAP	60,65	pituitary_adenylate_cyclase-activating_polypeptide	8,58	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the action of ginsenoside_Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes .
19914336	0	PACAP	85,90	pituitary_adenylate_cyclase-activating_polypeptide	33,83	PACAP	pituitary adenylate cyclase-activating polypeptide	116	116	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Possible association between the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- gene and major_depressive_disorder .
21185294	0	PACAP	64,69	pituitary_adenylate_cyclase-activating_polypeptide	12,62	PACAP	pituitary adenylate cyclase-activating polypeptide	116	116	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the plasma and milk of ruminant animals .
7624029	0	PACAP	91,96	pituitary_adenylate_cyclase-activating_polypeptide	39,89	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Mitogenic and antimitogenic effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in adult rat chromaffin cell cultures .
8102056	0	PACAP	74,79	pituitary_adenylate_cyclase-activating_polypeptide	22,72	PACAP	pituitary adenylate cyclase-activating polypeptide	11516(Tax:10090)	11516(Tax:10090)	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Stimulatory action of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on thyroid gland .
8532586	0	PACAP	88,93	pituitary_adenylate_cyclase-activating_polypeptide	36,86	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the adrenal medulla of the rat .
8714702	0	PACAP	100,105	pituitary_adenylate_cyclase-activating_polypeptide	48,98	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Tissue-specific and developmental expression of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- receptors in rat brain .
8943280	0	PACAP	96,101	pituitary_adenylate_cyclase-activating_polypeptide	44,94	PACAP	pituitary adenylate cyclase-activating polypeptide	116	116	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Molecular cloning of a novel variant of the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- receptor that stimulates calcium influx by activation of L-type calcium channels .
9191084	0	PACAP	66,71	pituitary_adenylate_cyclase-activating_polypeptide	14,64	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the mesencephalic trigeminal nucleus of the rat after transsection of the masseteric nerve .
9282945	0	PACAP	66,71	pituitary_adenylate_cyclase-activating_polypeptide	14,64	PACAP	pituitary adenylate cyclase-activating polypeptide	116	116	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- receptors and PACAP in human fetal retina .
9843161	0	PACAP	96,101	pituitary_adenylate_cyclase-activating_polypeptide	44,94	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Neurotrophic and neuroprotective effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on mesencephalic dopaminergic neurons .
9927311	0	PACAP	80,85	pituitary_adenylate_cyclase-activating_polypeptide	28,78	PACAP	pituitary adenylate cyclase-activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Gonadotropin stimulation of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- messenger ribonucleic_acid in the rat ovary and the role of PACAP as a follicle survival factor .
8728481	0	PACAP	62,67	pituitary_adenylate_cyclase_activating_peptide	14,60	PACAP	pituitary adenylate cyclase activating peptide	116	116	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of pituitary_adenylate_cyclase_activating_peptide -LRB- PACAP -RRB- on the nociceptive formalin test .
10219831	0	PACAP	71,76	pituitary_adenylate_cyclase_activating_polypeptide	19,69	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Central effects of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- on gastric_motility and emptying in rats .
10945291	0	PACAP	62,67	pituitary_adenylate_cyclase_activating_polypeptide	10,60	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- as a regulator of paracrine interactions between folliculo-stellate cells and gonadotropes through the control of activin-follistatin interactions .
11288374	0	PACAP	101,106	pituitary_adenylate_cyclase_activating_polypeptide	49,99	PACAP	pituitary adenylate cyclase activating polypeptide	116	116	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Structure , localization and physiologic role of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- -RSB- .
14560155	0	PACAP	59,64	pituitary_adenylate_cyclase_activating_polypeptide	7,57	PACAP	pituitary adenylate cyclase activating polypeptide	116	116	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Plasma pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- levels in chronic hepatitis_B patients under lamivudine treatment .
1522745	0	PACAP	75,80	pituitary_adenylate_cyclase_activating_polypeptide	23,73	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Contrasting effects of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- on in vivo and in vitro prolactin and growth hormone release in male rats .
16888234	0	PACAP	63,68	pituitary_adenylate_cyclase_activating_polypeptide	11,61	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- in detrusor_hyperreflexia after spinal_cord_injury -LRB- SCI -RRB- .
1730060	0	PACAP	75,80	pituitary_adenylate_cyclase_activating_polypeptide	23,73	PACAP	pituitary adenylate cyclase activating polypeptide	116	116	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure of the human pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- gene .
7724826	0	PACAP	66,71	pituitary_adenylate_cyclase_activating_polypeptide	14,64	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- gene by rat spermatogenic cells .
8868261	0	PACAP	76,81	pituitary_adenylate_cyclase_activating_polypeptide	24,74	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Facilitatory effects of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus -LRB- PVN -RRB- in vitro .
8951643	0	PACAP	68,73	pituitary_adenylate_cyclase_activating_polypeptide	16,66	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	116	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- immunoreactivity in the hypothalamus and extended amygdala of the rat .
9721947	0	PACAP	66,71	pituitary_adenylate_cyclase_activating_polypeptide	14,64	PACAP	pituitary adenylate cyclase activating polypeptide	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- in the postnatal and adult rat cerebellar cortex .
20569302	0	PACAP	57,62	stathmin_1	15,25	PACAP	stathmin 1	24166(Tax:10116)	29332(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Involvement of stathmin_1 in the neurotrophic effects of PACAP in PC12 cells .
10366751	0	PACAP-type_I_receptor	25,46	PAC1-R	17,23	PACAP-type I receptor	PAC1-R	117	117	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Induction of the PAC1-R -LRB- PACAP-type_I_receptor -RRB- gene by p53 and Zac .
16888229	0	PACAP_receptor	0,14	PAC1-R	16,22	PACAP receptor	PAC1-R	24167(Tax:10116)	24167(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	PACAP_receptor -LRB- PAC1-R -RRB- expression in rat and rhesus_monkey thymus .
14561729	0	PACE4	40,45	Hash-2	69,75	PACE4	Hash-2	5046	430	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta : possible role of placenta-specific basic helix-loop-helix transcription factor , human achaete-scute homologue-2 .
15925106	0	PACRG	46,51	parkin_co-regulated_gene	20,44	PACRG	parkin co-regulated gene	135138	135138	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Genetic analysis of parkin_co-regulated_gene -LRB- PACRG -RRB- in patients with early-onset parkinsonism .
26943323	0	PACS-2	0,6	Bcl-xL	72,78	PACS-2	Bcl-xL	217893(Tax:10090)	12048(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	PACS-2 mediates the ATM and NF-kB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage .
18296443	0	PACS-2	16,22	Nef	6,9	PACS-2	Nef	217893(Tax:10090)	57783(Tax:10090)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I -LRB- MHC-I -RRB- down-regulation : analysis using short interfering RNA and knock-out mice .
11076687	0	PACSIN2	0,7	ADAM13	58,64	PACSIN2	ADAM13	398138(Tax:8355)	386623(Tax:8355)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PACSIN2 is a regulator of the metalloprotease/disintegrin ADAM13 .
12354780	0	PACSIN_1	0,8	huntingtin	24,34	PACSIN 1	huntingtin	29993	3064	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PACSIN_1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington 's _ disease brains .
26454002	0	PACT	77,81	DDX3	0,4	PACT	DDX3	8575	1654	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	DDX3 functions in antiviral innate immunity through translational control of PACT .
24899174	0	PACT	133,137	NS1	144,147	PACT	NS1	8575	10625	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Quantitative proteomic analysis of the influenza_A_virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor .
11238927	0	PACT	21,25	PKR	71,74	PACT	PKR	5930	5610	Gene	Gene	structure|nmod|START_ENTITY structure|dep|domains domains|nmod|END_ENTITY	Modular structure of PACT : distinct domains for binding and activating PKR .
11985496	0	PACT	63,67	PKR	159,162	PACT	PKR	8575	5610	Gene	Gene	motif|nmod|START_ENTITY plays|nsubj|motif plays|dobj|role role|nmod|activation activation|nmod|kinase kinase|appos|END_ENTITY	The C-terminal , third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase -LRB- PKR -RRB- .
14585331	0	PACT	35,39	PKR	74,77	PACT	PKR	8575	5610	Gene	Gene	motifs|nmod|START_ENTITY have|nsubj|motifs have|dobj|effects effects|nmod|activity activity|compound|END_ENTITY	The carboxy-terminal , M3 motifs of PACT and TRBP have opposite effects on PKR activity .
16466763	0	PACT	104,108	PKR	48,51	PACT	PKR	8575	5610	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|Binding Binding|nmod|protein protein|nmod|END_ENTITY	Binding of the influenza_A_virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA .
16785445	0	PACT	38,42	PKR	20,23	PACT	PKR	5930	5610	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|basis basis|nmod|END_ENTITY	Molecular basis for PKR activation by PACT or dsRNA .
16982605	0	PACT	76,80	PKR	51,54	PACT	PKR	8575	5610	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis .
19580324	0	PACT	42,46	PKR	24,27	PACT	PKR	5930	5610	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|analysis analysis|nmod|END_ENTITY	Biochemical analysis of PKR activation by PACT .
22473766	0	PACT	30,34	PKR	91,94	PACT	PKR	8575	5610	Gene	Gene	molecules|amod|START_ENTITY interaction|nmod|molecules required|nsubjpass|interaction required|nmod|activation activation|compound|END_ENTITY	Increased interaction between PACT molecules in response to stress signals is required for PKR activation .
24020926	0	PACT	19,23	PKR	35,38	PACT	PKR	8575	5610	Gene	Gene	activator|appos|START_ENTITY becomes|nsubj|activator becomes|xcomp|inhibitor inhibitor|compound|END_ENTITY	The PKR activator , PACT , becomes a PKR inhibitor during HIV-1 replication .
24020926	0	PACT	19,23	PKR	4,7	PACT	PKR	8575	5610	Gene	Gene	activator|appos|START_ENTITY activator|compound|END_ENTITY	The PKR activator , PACT , becomes a PKR inhibitor during HIV-1 replication .
26231208	0	PACT	127,131	PKR	37,40	PACT	PKR	8575	5610	Gene	Gene	mutation|nmod|START_ENTITY carrying|dobj|mutation cells|acl|carrying kinase|nmod|cells kinase|dobj|END_ENTITY	Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT .
26231208	0	PACT	127,131	PKR	37,40	PACT	PKR	8575	5610	Gene	Gene	mutation|nmod|START_ENTITY carrying|dobj|mutation cells|acl|carrying kinase|nmod|cells kinase|dobj|END_ENTITY	Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT .
21501829	0	PACT	40,44	RIG-I	82,87	PACT	RIG-I	8575	23586	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response .
17470788	0	PACT	0,4	p53	32,35	PACT	p53	19647(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PACT is a negative regulator of p53 and essential for cell growth and embryonic development .
9010216	0	PACT	0,4	p53	49,52	PACT	p53	5930	7157	Gene	Gene	START_ENTITY|dep|cloning cloning|nmod|protein protein|compound|END_ENTITY	PACT : cloning and characterization of a cellular p53 binding protein that interacts with Rb .
24298040	0	PAD	57,60	peptidylarginine_deiminase	29,55	PAD	peptidylarginine deiminase	23569	23569	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Methods for the detection of peptidylarginine_deiminase -LRB- PAD -RRB- activity and protein citrullination .
20668670	0	PAD2	49,53	peptidylarginine_deiminase_2	19,47	PAD2	peptidylarginine deiminase 2	11240	11240	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role for peptidylarginine_deiminase_2 -LRB- PAD2 -RRB- in citrullination of canine mammary epithelial cell histones .
22126893	0	PAD4	61,65	peptidylarginine_deiminase_4	31,59	PAD4	peptidylarginine deiminase 4	23569	23569	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and expression of peptidylarginine_deiminase_4 -LRB- PAD4 -RRB- in mammalian oocytes and preimplantation embryos .
1716887	0	PADGEM	98,104	IL-1_beta	15,24	PADGEM	IL-1 beta	6403	3553	Gene	Gene	Enhancement|dep|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement by IL-1_beta and IFN-gamma of platelet activation : adhesion to leukocytes via GMP-140 / PADGEM protein -LRB- CD62 -RRB- .
17851584	0	PADI1	111,116	peptidylarginine_deiminase_type_I	71,104	PADI1	peptidylarginine deiminase type I	29943	29943	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine_deiminase_type_I gene -LRB- PADI1 -RRB- in human keratinocytes .
16671893	0	PADI3	113,118	peptidylarginine_deiminase_type_III	71,106	PADI3	peptidylarginine deiminase type III	51702	51702	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine_deiminase_type_III gene -LRB- PADI3 -RRB- in human keratinocytes .
17456793	0	PADI4	59,64	peptidylarginine_deiminase_type_IV	18,52	PADI4	peptidylarginine deiminase type IV	23569	23569	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Estrogen-enhanced peptidylarginine_deiminase_type_IV gene -LRB- PADI4 -RRB- expression in MCF-7 cells is mediated by estrogen receptor-alpha-promoted transfactors activator_protein-1 , nuclear factor-Y , and Sp1 .
14611633	0	PAF	38,41	platelet-activating_factor	10,36	PAF	platelet-activating factor	9768	9768	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of platelet-activating_factor -LRB- PAF -RRB- on stallion sperm motility , capacitation and the acrosome reaction .
1794301	0	PAF	39,42	platelet-activating_factor	11,37	PAF	platelet-activating factor	9768	9768	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of platelet-activating_factor -LRB- PAF -RRB- from human colon mucosa and its inhibition by 5-aminosalicylic_acid .
1819722	0	PAF	40,43	platelet-activating_factor	12,38	PAF	platelet-activating factor	9768	9768	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of platelet-activating_factor -LRB- PAF -RRB- in experimental glomerular_injury .
1819735	0	PAF	43,46	platelet-activating_factor	15,41	PAF	platelet-activating factor	9768	9768	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of platelet-activating_factor -LRB- PAF -RRB- in septic_shock and priming as indicated by the effect of hetrazepinoic_PAF antagonists .
2519900	0	PAF	54,57	platelet-activating_factor	26,52	PAF	platelet-activating factor	9768	9768	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated plasma levels of platelet-activating_factor -LRB- PAF -RRB- in breast_cancer patients with hypercalcemia .
2536413	0	PAF	42,45	platelet-activating_factor	14,40	PAF	platelet-activating factor	9768	9768	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of platelet-activating_factor -LRB- PAF -RRB- - induced chemotaxis and PAF binding to human eosinophils and neutrophils by the specific ginkgolide-derived PAF antagonist , BN_52021 .
2703999	0	PAF	36,39	platelet-activating_factor	8,34	PAF	platelet-activating factor	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of platelet-activating_factor -LRB- PAF -RRB- in the initiation of the decidual reaction in the rat .
6253571	0	PAF	54,57	platelet-activating_factor	26,52	PAF	platelet-activating factor	9768	9768	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and release of platelet-activating_factor -LRB- PAF -RRB- ; dissociation from degranulation and superoxide production in the human neutrophil .
7981886	0	PAF	40,43	platelet-activating_factor	12,38	PAF	platelet-activating factor	9768	9768	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of platelet-activating_factor -LRB- PAF -RRB- in interstitial_pulmonary_disease .
8358021	0	PAF	43,46	platelet-activating_factor	15,41	PAF	platelet-activating factor	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of platelet-activating_factor -LRB- PAF -RRB- in endotoxin - or ischaemia-induced intestinal hyperpermeability in the rat .
8390724	0	PAF	11,14	platelet-activating_factor	16,42	PAF	platelet-activating factor	9768	9768	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of PAF -LRB- platelet-activating_factor -RRB- on hemostasis .
8655220	0	PAF	46,49	platelet-activating_factor	18,44	PAF	platelet-activating factor	9768	9768	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	The production of platelet-activating_factor -LRB- PAF -RRB- during hemodialysis with cuprophane membrane .
9890553	0	PAF	42,45	platelet-activating_factor	14,40	PAF	platelet-activating factor	9768	9768	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Heterogeneous platelet-activating_factor -LRB- PAF -RRB- receptors and calcium increase in platelets and macrophages .
9892046	0	PAF	64,67	platelet-activating_factor	36,62	PAF	platelet-activating factor	109585(Tax:10090)	109585(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Effect of Y-24180 , an antagonist at platelet-activating_factor -LRB- PAF -RRB- receptors , on IgE-mediated cutaneous reactions in mice .
15735601	0	PAF	45,48	platelet_activating_factor	17,43	PAF	platelet activating factor	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Direct action of platelet_activating_factor -LRB- PAF -RRB- induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis .
1843897	0	PAF	39,42	platelet_activating_factor	11,37	PAF	platelet activating factor	9768	9768	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of platelet_activating_factor -LRB- PAF -RRB- on granulocyte migration in vivo in patients with atopic_asthma -RSB- .
2554526	0	PAF	70,73	platelet_activating_factor	75,101	PAF	platelet activating factor	9768	9768	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Sheep platelets as a model for human platelets : evidence for specific PAF -LRB- platelet_activating_factor -RRB- receptors .
3402585	0	PAF	39,42	platelet_activating_factor	11,37	PAF	platelet activating factor	9768	9768	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of platelet_activating_factor -LRB- PAF -RRB- on human citrated whole blood .
3619905	0	PAF	50,53	platelet_activating_factor	22,48	PAF	platelet activating factor	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Spasmogenic effect of platelet_activating_factor -LRB- PAF -RRB- on isolated rat stomach fundus strip .
3947392	1	PAF	79,82	platelet_activating_factor	51,77	PAF	platelet activating factor	9768	9768	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of platelet_activating_factor -LRB- PAF -RRB- with human serum alpha-1-acid glycoprotein -LRB- AAG -RRB- .
6482659	0	PAF	38,41	platelet_activating_factor	10,36	PAF	platelet activating factor	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of platelet_activating_factor -LRB- PAF -RRB- on blood flow distribution in the spontaneously hypertensive rat .
6695148	0	PAF	32,35	platelet_aggregating_factor	37,64	PAF	platelet aggregating factor	9768	9768	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of the pure synthetic PAF -LRB- platelet_aggregating_factor -RRB- on clot retraction and platelet_aggregation .
19500354	0	PAF-AH	104,110	Lp-PLA2	41,48	PAF-AH	Lp-PLA2	7941	7941	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity , platelet-activating factor acetylhydrolase -LRB- PAF-AH -RRB- in leukocytes and body composition in healthy adults .
11377588	0	PAF-AH	110,116	PAF-acetylhydrolase	89,108	PAF-AH	PAF-acetylhydrolase	282311(Tax:9913)	282311(Tax:9913)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Platelet-activating factor -LRB- PAF -RRB- - like activity , localization of PAF_receptor -LRB- PAF-R -RRB- and PAF-acetylhydrolase -LRB- PAF-AH -RRB- activity in bovine endometrium at different stages of the estrous cycle and early pregnancy * PAF-like activity in the endometrium increased from days 2-4 to day 12 and day 20 in both cyclic and pregnant cows .
11403499	0	PAF-AH	110,116	PAF-acetylhydrolase	89,108	PAF-AH	PAF-acetylhydrolase	282311(Tax:9913)	282311(Tax:9913)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Platelet-activating factor -LRB- PAF -RRB- - like activity , localization of PAF_receptor -LRB- PAF-R -RRB- and PAF-acetylhydrolase -LRB- PAF-AH -RRB- activity in bovine endometrium at different stages of the estrous cycle and early pregnancy .
9131139	0	PAF-AH	40,46	PAF_and_acetylhydrolase	15,38	PAF-AH	PAF and acetylhydrolase	5048	5048;9768	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Implication of PAF_and_acetylhydrolase -LRB- PAF-AH -RRB- activity in periodontal disease .
17384835	0	PAF-AH	44,50	Platelet-activating_factor_acetylhydrolase	0,42	PAF-AH	Platelet-activating factor acetylhydrolase	5048	5048	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity in patients with type_1_diabetes_mellitus .
10781653	0	PAF-AH	72,78	platelet-activating_factor_acetylhydrolase	28,70	PAF-AH	platelet-activating factor acetylhydrolase	5048	5048	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Correlations between plasma platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity and PAF-AH genotype , age , and atherosclerosis in a Japanese population .
11580924	0	PAF-AH	50,56	platelet-activating_factor_acetylhydrolase	6,48	PAF-AH	platelet-activating factor acetylhydrolase	5048	5048	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Serum platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity in more than 3000 healthy Japanese .
12787800	0	PAF-AH	50,56	platelet-activating_factor_acetylhydrolase	6,48	PAF-AH	platelet-activating factor acetylhydrolase	5048	5048	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Serum platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity in patients with hyperbilirubinemic_hepatobiliary_disease .
15572112	0	PAF-acetylhydrolase	79,98	LIS1	58,62	PAF-acetylhydrolase	LIS1	7941	5048	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Coupling PAF signaling to dynein regulation : structure of LIS1 in complex with PAF-acetylhydrolase .
11377588	0	PAF-acetylhydrolase	89,108	PAF-AH	110,116	PAF-acetylhydrolase	PAF-AH	282311(Tax:9913)	282311(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Platelet-activating factor -LRB- PAF -RRB- - like activity , localization of PAF_receptor -LRB- PAF-R -RRB- and PAF-acetylhydrolase -LRB- PAF-AH -RRB- activity in bovine endometrium at different stages of the estrous cycle and early pregnancy * PAF-like activity in the endometrium increased from days 2-4 to day 12 and day 20 in both cyclic and pregnant cows .
11403499	0	PAF-acetylhydrolase	89,108	PAF-AH	110,116	PAF-acetylhydrolase	PAF-AH	282311(Tax:9913)	282311(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Platelet-activating factor -LRB- PAF -RRB- - like activity , localization of PAF_receptor -LRB- PAF-R -RRB- and PAF-acetylhydrolase -LRB- PAF-AH -RRB- activity in bovine endometrium at different stages of the estrous cycle and early pregnancy .
8507159	0	PAFAH	96,101	PAF_acetylhydrolase	75,94	PAFAH	PAF acetylhydrolase	7941	7941	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	-LSB- Increased plasma levels of platelet-activating_factor -LRB- PAF -RRB- and low serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adult patients with bronchial_asthma -RSB- .
8507159	0	PAFAH	96,101	platelet-activating_factor	28,54	PAFAH	platelet-activating factor	7941	9768	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Increased plasma levels of platelet-activating_factor -LRB- PAF -RRB- and low serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adult patients with bronchial_asthma -RSB- .
8833165	0	PAFAH	100,105	platelet-activating_factor	26,52	PAFAH	platelet-activating factor	7941	9768	Gene	Gene	PAF_acetylhydrolase|parataxis|START_ENTITY PAF_acetylhydrolase|nsubj|level level|nmod|END_ENTITY	Increased plasma level of platelet-activating_factor -LRB- PAF -RRB- and decreased serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adults with bronchial_asthma .
11754098	0	PAFAH1B1	85,93	LIS1	74,78	PAFAH1B1	LIS1	5048	5048	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Clinical and molecular basis of classical lissencephaly : Mutations in the LIS1 gene -LRB- PAFAH1B1 -RRB- .
20846927	0	PAFAH1B1	144,152	LIS1	154,158	PAFAH1B1	LIS1	5048	5048	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An isolated case of lissencephaly caused by the insertion of a mitochondrial genome-derived DNA sequence into the 5 ' untranslated region of the PAFAH1B1 -LRB- LIS1 -RRB- gene .
21595003	0	PAFAH1B1	60,68	LIS1	70,74	PAFAH1B1	LIS1	5048	5048	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A microduplication on chromosome 17p13 .1 p13 .3 including the PAFAH1B1 -LRB- LIS1 -RRB- gene .
23260771	0	PAFR	49,53	platelet-activating_factor_receptor	12,47	PAFR	platelet-activating factor receptor	19204(Tax:10090)	19204(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of platelet-activating_factor_receptor -LRB- PAFR -RRB- in lung pathology during experimental malaria .
8507159	0	PAF_acetylhydrolase	75,94	PAFAH	96,101	PAF acetylhydrolase	PAFAH	7941	7941	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	-LSB- Increased plasma levels of platelet-activating_factor -LRB- PAF -RRB- and low serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adult patients with bronchial_asthma -RSB- .
1846878	0	PAF_acetylhydrolase	62,81	Platelet-activating_factor	0,26	PAF acetylhydrolase	Platelet-activating factor	7941	9768	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Platelet-activating_factor -LRB- PAF -RRB- stimulates the production of PAF_acetylhydrolase by the human hepatoma cell line , HepG2 .
8507159	0	PAF_acetylhydrolase	75,94	platelet-activating_factor	28,54	PAF acetylhydrolase	platelet-activating factor	7941	9768	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	-LSB- Increased plasma levels of platelet-activating_factor -LRB- PAF -RRB- and low serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adult patients with bronchial_asthma -RSB- .
8833165	0	PAF_acetylhydrolase	79,98	platelet-activating_factor	26,52	PAF acetylhydrolase	platelet-activating factor	7941	9768	Gene	Gene	START_ENTITY|nsubj|level level|nmod|END_ENTITY	Increased plasma level of platelet-activating_factor -LRB- PAF -RRB- and decreased serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adults with bronchial_asthma .
9131139	0	PAF_and_acetylhydrolase	15,38	PAF-AH	40,46	PAF and acetylhydrolase	PAF-AH	5048;9768	5048	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Implication of PAF_and_acetylhydrolase -LRB- PAF-AH -RRB- activity in periodontal disease .
12420294	0	PAFr	101,105	platelet-activating_factor_receptor	64,99	PAFr	platelet-activating factor receptor	5724	5724	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal location , structure , and temporal expression of the platelet-activating_factor_receptor -LRB- PAFr -RRB- gene in porcine endometrium and embryos relative to estrogen_receptor_alpha gene expression .
25660740	0	PAG	59,62	pregnancy-associated_glycoprotein	24,57	PAG	pregnancy-associated glycoprotein	517463(Tax:9913)	517463(Tax:9913)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Factors associated with pregnancy-associated_glycoprotein -LRB- PAG -RRB- levels in plasma and milk of Holstein cows during early pregnancy and their effect on the accuracy of pregnancy diagnosis .
17010415	0	PAG-1	44,49	pregnancy-associated_glycoprotein-1	7,42	PAG-1	pregnancy-associated glycoprotein-1	281964(Tax:9913)	281964(Tax:9913)	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Plasma pregnancy-associated_glycoprotein-1 -LRB- PAG-1 -RRB- concentrations during gestation in Neospora-infected dairy cows .
11689294	0	PAG608	52,58	WIG-1	46,51	PAG608	WIG-1	3499451(Tax:1359)	64393	Gene	Gene	START_ENTITY|dep|localization localization|nmod|END_ENTITY	Cloning and chromosomal localization of human WIG-1 / PAG608 and demonstration of amplification with increased expression in primary squamous_cell_carcinoma_of_the_lung .
11139255	0	PAH	59,62	phenylalanine_hydroxylase	27,52	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ten novel mutations in the phenylalanine_hydroxylase gene -LRB- PAH -RRB- observed in Brazilian patients with phenylketonuria .
11180595	0	PAH	44,47	phenylalanine_hydroxylase	17,42	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene in Brazilian patients with phenylketonuria .
15730960	0	PAH	55,58	phenylalanine_hydroxylase	28,53	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Mutations in exon 7 of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene in chinese patients with phenylketonuria -RSB- .
16931086	0	PAH	89,92	phenylalanine_hydroxylase	62,87	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of large deletions in the phenylalanine_hydroxylase -LRB- PAH -RRB- gene by MLPA : evidence for both homologous and non-homologous mechanisms of rearrangement .
18294361	0	PAH	54,57	phenylalanine_hydroxylase	27,52	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A mutation analysis of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene in the Israeli population .
18299955	0	PAH	88,91	phenylalanine_hydroxylase	61,86	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotype-phenotype correlations analysis of mutations in the phenylalanine_hydroxylase -LRB- PAH -RRB- gene .
23898865	0	PAH	79,82	phenylalanine_hydroxylase	52,77	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Possible association between common variants of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene and memory performance in healthy adults .
24401910	0	PAH	56,59	phenylalanine_hydroxylase	29,54	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The mutation spectrum of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene and associated haplotypes reveal ethnic heterogeneity in the Taiwanese population .
9781015	0	PAH	48,51	phenylalanine_hydroxylase	16,41	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation at the phenylalanine_hydroxylase gene -LRB- PAH -RRB- and its use to document population genetic variation : the Quebec experience .
9792411	0	PAH	153,156	phenylalanine_hydroxylase	121,146	PAH	phenylalanine hydroxylase	5053	5053	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Alterations in protein_aggregation and degradation due to mild and severe missense mutations -LRB- A104D , R157N -RRB- in the human phenylalanine_hydroxylase gene -LRB- PAH -RRB- .
15694837	0	PAHX-AP1	147,155	Dual-specificity_tyrosine-phosphorylated_and_regulated_kinase_1A	0,64	PAHX-AP1	Dual-specificity tyrosine-phosphorylated and regulated kinase 1A	9796	1859	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dual-specificity_tyrosine-phosphorylated_and_regulated_kinase_1A -LRB- DYRK1A -RRB- interacts with the phytanoyl-CoA_alpha-hydroxylase associated protein 1 -LRB- PAHX-AP1 -RRB- , a brain specific protein .
2515610	0	PAI	50,53	plasminogen_activator_inhibitor	17,48	PAI	plasminogen activator inhibitor	5054	5054	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Determination of plasminogen_activator_inhibitor -LRB- PAI -RRB- activity of human plasma after dilution in a PAI-depleted plasma .
26349765	0	PAI-1	54,59	BRD2	22,26	PAI-1	BRD2	18787(Tax:10090)	14312(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	The Epigenetic Reader BRD2 as a Specific Modulator of PAI-1 Expression in Lipopolysaccharide-Stimulated Mouse Primary Astrocytes .
26944191	0	PAI-1	144,149	CREB	101,105	PAI-1	CREB	5054	1385	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	MnTE-2-PyP_reduces_prostate_cancer growth and metastasis by suppressing p300 activity and p300/HIF -1 / CREB binding to the promoter region of the PAI-1 gene .
20953304	0	PAI-1	48,53	EGFR	71,75	PAI-1	EGFR	5054	1956	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	TGF-b1-Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling .
24265642	0	PAI-1	40,45	EGFR	116,120	PAI-1	EGFR	5054	1956	Gene	Gene	Associated|dep|START_ENTITY Associated|nmod|Prognosis Prognosis|nmod|Patients Patients|nmod|Adenocarcinoma Adenocarcinoma|compound|END_ENTITY	Plasminogen_Activator_Inhibitor_Type_1 -LRB- PAI-1 -RRB- A15T Gene Polymorphism Is Associated with Prognosis in Patients with EGFR Mutation Positive Pulmonary Adenocarcinoma .
16210568	0	PAI-1	28,33	Fibrinogen	0,10	PAI-1	Fibrinogen	5054	2244	Gene	Gene	sites|amod|START_ENTITY contains|dobj|sites contains|nsubj|END_ENTITY	Fibrinogen contains cryptic PAI-1 binding sites that are exposed on binding to solid surfaces or limited proteolysis .
23657855	0	PAI-1	75,80	HDAC11	24,30	PAI-1	HDAC11	18787(Tax:10090)	232232(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Gender-specific role of HDAC11 in kidney_ischemia - and reperfusion-induced PAI-1 expression and injury .
19147015	0	PAI-1	30,35	ID-1	36,40	PAI-1	ID-1	5054	3397	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	Ionizing radiation shifts the PAI-1 / ID-1 balance and activates notch signaling in endothelial cells .
8798151	0	PAI-1	99,104	LRP	119,122	PAI-1	LRP	18787(Tax:10090)	16971(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Embryo implantation in mouse : fetomaternal coordination in the pattern of expression of uPA , uPAR , PAI-1 and alpha_2MR / LRP genes .
17689411	0	PAI-1	15,20	PAI-1	72,77	PAI-1	PAI-1	5054	5054	Gene	Gene	Association|nmod|START_ENTITY G/A|nsubj|Association G/A|dobj|polymorphism polymorphism|nmod|levels levels|compound|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphism and changes in PAI-1 / tPA levels in stroke : a case-control study .
17689411	0	PAI-1	72,77	PAI-1	15,20	PAI-1	PAI-1	5054	5054	Gene	Gene	levels|compound|START_ENTITY polymorphism|nmod|levels G/A|dobj|polymorphism G/A|nsubj|Association Association|nmod|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphism and changes in PAI-1 / tPA levels in stroke : a case-control study .
8569037	0	PAI-1	108,113	PAI-1	91,96	PAI-1	PAI-1	5054	5054	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	-LSB- Studies on the mechanism of hyperfibrinolysis in liver_cirrhosis -- changes of plasma t-PA , PAI-1 and active PAI-1 levels in liver_cirrhosis -RSB- .
8569037	0	PAI-1	91,96	PAI-1	108,113	PAI-1	PAI-1	5054	5054	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	-LSB- Studies on the mechanism of hyperfibrinolysis in liver_cirrhosis -- changes of plasma t-PA , PAI-1 and active PAI-1 levels in liver_cirrhosis -RSB- .
15990085	0	PAI-1	49,54	PPARgamma	70,79	PAI-1	PPARgamma	5054	5468	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation .
17578681	0	PAI-1	35,40	Plasminogen_Activator_Inhibitor-1	0,33	PAI-1	Plasminogen Activator Inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Plasminogen_Activator_Inhibitor-1 -LRB- PAI-1 -RRB- gene 4G/5G alleles frequency distribution in the Lebanese population .
17903340	0	PAI-1	70,75	Plasminogen_Activator_Inhibitor_1	35,68	PAI-1	Plasminogen Activator Inhibitor 1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The -675 4G/5G polymorphism at the Plasminogen_Activator_Inhibitor_1 -LRB- PAI-1 -RRB- gene modulates plasma Plasminogen_Activator_Inhibitor_1 concentrations in response to dietary fat consumption .
8560407	0	PAI-1	35,40	Plasminogen_activator_inhibitor-1	0,33	PAI-1	Plasminogen activator inhibitor-1	5054	5054	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- promoter polymorphism and coronary_artery_disease in non-insulin-dependent_diabetes .
9279972	0	PAI-1	35,40	Plasminogen_activator_inhibitor-1	0,33	PAI-1	Plasminogen activator inhibitor-1	5054	5054	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- content in platelets from healthy individuals genotyped for the 4G/5G polymorphism in the PAI-1 gene .
20356416	0	PAI-1	92,97	SERPINE1	82,90	PAI-1	SERPINE1	5054	5054	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	`` Hypoxia-induced down-regulation of microRNA-449a / b impairs control over targeted SERPINE1 -LRB- PAI-1 -RRB- mRNA - a mechanism involved in SERPINE1 -LRB- PAI-1 -RRB- overexpression '' .
21375729	0	PAI-1	91,96	SERPINE1	81,89	PAI-1	SERPINE1	5054	5054	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Hypoxia-induced down-regulation of microRNA-449a / b impairs control over targeted SERPINE1 -LRB- PAI-1 -RRB- mRNA - a mechanism involved in SERPINE1 -LRB- PAI-1 -RRB- overexpression .
24249967	0	PAI-1	10,15	SERPINE1	0,8	PAI-1	SERPINE1	5054	5054	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	SERPINE1 , PAI-1 protein coding gene , methylation levels and epigenetic relationships with adiposity_changes_in_obese_subjects with metabolic_syndrome features under dietary restriction .
19055748	0	PAI-1	0,5	SNAI1	33,38	PAI-1	SNAI1	5054	6615	Gene	Gene	blockade|amod|START_ENTITY blockade|nmod|END_ENTITY	PAI-1 and functional blockade of SNAI1 in breast_cancer cell migration .
15372629	0	PAI-1	86,91	Smad2/3	57,64	PAI-1	Smad2/3	18787(Tax:10090)	17126;17127	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	Transforming_growth_factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian_cancer cells .
24987792	0	PAI-1	70,75	TGF-b1	91,97	PAI-1	TGF-b1	5054	7040	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Cross-talk Between Human Mast Cells and Bronchial Epithelial Cells in PAI-1 Production via TGF-b1 .
10209301	0	PAI-1	60,65	TGF-beta	15,23	PAI-1	TGF-beta	29366(Tax:10116)	59086(Tax:10116)	Gene	Gene	upregulation|compound|START_ENTITY signaling|nmod|upregulation Association|acl|signaling Association|nmod|END_ENTITY	Association of TGF-beta signaling in angiotensin_II-induced PAI-1 mRNA upregulation in mesangial cells : role of PKC .
16105028	0	PAI-1	34,39	TGF-beta	59,67	PAI-1	TGF-beta	24617(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	MAPK/AP -1 - dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells .
16139837	0	PAI-1	77,82	TGF-beta1	55,64	PAI-1	TGF-beta1	281375(Tax:9913)	282089(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Identification of intracellular pathways through which TGF-beta1 upregulates PAI-1 expression in endothelial cells .
17047299	0	PAI-1	52,57	TGF-beta1	4,13	PAI-1	TGF-beta1	5054	7040	Gene	Gene	gene|compound|START_ENTITY stimulatory|dep|gene END_ENTITY|dep|stimulatory	The TGF-beta1 / upstream stimulatory factor-regulated PAI-1 gene : potential involvement and a therapeutic target in Alzheimer 's _ disease .
17328891	0	PAI-1	38,43	TGF-beta1	14,23	PAI-1	TGF-beta1	5054	7040	Gene	Gene	expression|compound|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of TGF-beta1 / MAPK-mediated PAI-1 gene expression by the actin cytoskeleton in human mesangial cells .
17515947	0	PAI-1	0,5	TGF-beta1	46,55	PAI-1	TGF-beta1	5054	7040	Gene	Gene	Regulator|nsubj|START_ENTITY Regulator|nmod|END_ENTITY	PAI-1 is a Critical Upstream Regulator of the TGF-beta1 / EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous_Squamous_Cell_Carcinoma .
19383899	0	PAI-1	162,167	TGF-beta1	0,9	PAI-1	TGF-beta1	5054	7040	Gene	Gene	role|nmod|START_ENTITY axis|dep|role plasmin/MMP|dep|axis coupled|nmod|plasmin/MMP coupled|nsubjpass|potential potential|compound|END_ENTITY	TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP -10 / MMP-1-dependent collagen remodeling axis : role for PAI-1 .
20428185	0	PAI-1	0,5	TGF-beta1	19,28	PAI-1	TGF-beta1	5054	7040	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|response response|amod|END_ENTITY	PAI-1 mediates the TGF-beta1 + EGF-induced `` scatter '' response in transformed human keratinocytes .
24962629	0	PAI-1	73,78	TGF-beta1	0,9	PAI-1	TGF-beta1	18787(Tax:10090)	21803(Tax:10090)	Gene	Gene	Cells|nmod|START_ENTITY Plasmin|nmod|Cells Plasmin|compound|END_ENTITY	TGF-beta1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1 : Implications for Scarless Flexor Tendon Repair .
12506026	0	PAI-1	117,122	TNF_alpha	98,107	PAI-1	TNF alpha	5054	7124	Gene	Gene	expression|compound|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	Direct binding of Nur77/NAK -1 to the plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- promoter regulates TNF_alpha - induced PAI-1 expression .
12811828	0	PAI-1	14,19	TNFalpha	54,62	PAI-1	TNFalpha	5054	7124	Gene	Gene	syntheses|amod|START_ENTITY syntheses|nmod|END_ENTITY	Modulation of PAI-1 and proMMP-9 syntheses by soluble TNFalpha and its receptors during differentiation of the human monocytic HL-60 cell line .
15990085	0	PAI-1	49,54	TNFalpha	27,35	PAI-1	TNFalpha	5054	7124	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation .
17661167	0	PAI-1	22,27	TPA	68,71	PAI-1	TPA	5054	5327	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|nmod|gene gene|compound|END_ENTITY	4G/5G polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic_ovary_syndrome .
2124638	0	PAI-1	127,132	TPA	71,74	PAI-1	TPA	5054	100128998	Gene	Gene	antigen|appos|START_ENTITY levels|nmod|antigen -RSB-|nsubj|levels -RSB-|advcl|-LSB- -LSB-|dobj|correlation correlation|nmod|activity activity|nmod|tissue_plasminogen_activator tissue_plasminogen_activator|appos|END_ENTITY	-LSB- The correlation between the activity of tissue_plasminogen_activator -LRB- TPA -RRB- , levels of tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- antigen and serum lipids in healthy subjects -RSB- .
9264480	0	PAI-1	171,176	TPA	137,140	PAI-1	TPA	5054	100128998	Gene	Gene	levels|compound|START_ENTITY patients|nmod|levels relationship|nmod|patients relationship|nmod|antigen antigen|compound|END_ENTITY	Clearance of tissue_plasminogen_activator -LRB- TPA -RRB- and TPA/plasminogen _ activator_inhibitor_type_1 -LRB- PAI-1 -RRB- complex : relationship to elevated TPA antigen in patients with high PAI-1 activity levels .
9264480	0	PAI-1	171,176	TPA	43,46	PAI-1	TPA	5054	100128998	Gene	Gene	levels|compound|START_ENTITY patients|nmod|levels relationship|nmod|patients Clearance|dep|relationship Clearance|nmod|tissue_plasminogen_activator tissue_plasminogen_activator|appos|END_ENTITY	Clearance of tissue_plasminogen_activator -LRB- TPA -RRB- and TPA/plasminogen _ activator_inhibitor_type_1 -LRB- PAI-1 -RRB- complex : relationship to elevated TPA antigen in patients with high PAI-1 activity levels .
1721912	0	PAI-1	56,61	Thrombin	0,8	PAI-1	Thrombin	5054	2147	Gene	Gene	plasminogen_activator_inhibitor_1|appos|START_ENTITY neutralizes|dobj|plasminogen_activator_inhibitor_1 neutralizes|nsubj|END_ENTITY	Thrombin neutralizes plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- that is complexed with vitronectin in the endothelial cell matrix .
12437099	0	PAI-1	55,60	Vn	80,82	PAI-1	Vn	5054	7448	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- with vitronectin -LRB- Vn -RRB- : mapping the binding sites on PAI-1 and Vn .
25501306	0	PAI-1	105,110	angiotensin-converting_enzyme	30,59	PAI-1	angiotensin-converting enzyme	5054	1636	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Polymorphism and synergism of angiotensin-converting_enzyme -LRB- ACE -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- genes in coronary_artery_disease .
20216986	0	PAI-1	75,80	hypoxia-inducible_factor-1alpha	97,128	PAI-1	hypoxia-inducible factor-1alpha	5054	3091	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The adaptor protein Ruk/CIN85 activates plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression via hypoxia-inducible_factor-1alpha .
11162462	0	PAI-1	11,16	insulin	70,77	PAI-1	insulin	5054	3630	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Release of PAI-1 by human preadipocytes and adipocytes independent of insulin and IGF-1 .
15149338	0	PAI-1	49,54	jun-N-terminal_kinase	0,21	PAI-1	jun-N-terminal kinase	5054	5599	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	jun-N-terminal_kinase regulates thrombin-induced PAI-1 gene expression in proximal tubular epithelial cells .
17604327	0	PAI-1	47,52	oncostatin_M	26,38	PAI-1	oncostatin M	5054	5008	Gene	Gene	cells|amod|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	The inflammatory cytokine oncostatin_M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways .
10880342	0	PAI-1	90,95	plasminogen-activator_inhibitor_type-1	50,88	PAI-1	plasminogen-activator inhibitor type-1	5054	5054	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sp1-like activity mediates angiotensin-II-induced plasminogen-activator_inhibitor_type-1 -LRB- PAI-1 -RRB- gene expression in mesangial cells .
7642963	0	PAI-1	49,54	plasminogen_activator-inhibitor-1	14,47	PAI-1	plasminogen activator-inhibitor-1	24617(Tax:10116)	24617(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of plasminogen_activator-inhibitor-1 -LRB- PAI-1 -RRB- during cellular remodeling in proliferative glomerulonephritis in the rat .
8435984	0	PAI-1	88,93	plasminogen_activator_inhibitor	55,86	PAI-1	plasminogen activator inhibitor	5054	5054	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Insulin therapy in type 2 diabetic subjects suppresses plasminogen_activator_inhibitor -LRB- PAI-1 -RRB- activity and proinsulin-like molecules independently of glycaemic control .
10436140	0	PAI-1	172,177	plasminogen_activator_inhibitor-1	137,170	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Clinical implications of elevated PAI-1 revisited : multiple arterial_thrombosis in a patient with essential thrombocythemia and elevated plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels : a case report and review of the literature .
10494774	0	PAI-1	53,58	plasminogen_activator_inhibitor-1	18,51	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regular exercise , plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- activity and the 4G/5G promoter polymorphism in the PAI-1 gene .
11164859	0	PAI-1	62,67	plasminogen_activator_inhibitor-1	27,60	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vitamins_C_and_E attenuate plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in a hypercholesterolemic_porcine_model_of_angioplasty .
11244954	0	PAI-1	54,59	plasminogen_activator_inhibitor-1	19,52	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The expression of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene in human astrocytomas -RSB- .
11470783	0	PAI-1	117,122	plasminogen_activator_inhibitor-1	82,115	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene by the alkylating agent N-methyl-N ' - nitro-N-nitrosoguanidine .
11972486	0	PAI-1	61,66	plasminogen_activator_inhibitor-1	26,59	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism 4G/5G in the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene is associated with IgE-mediated allergic_diseases and asthma in the Czech population .
12501010	0	PAI-1	88,93	plasminogen_activator_inhibitor-1	53,86	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cerivastatin , a HMG-CoA_reductase inhibitor , reduces plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity .
12745658	0	PAI-1	43,48	plasminogen_activator_inhibitor-1	8,41	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Role of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels in the diagnosis of BMT-associated hepatic_veno-occlusive_disease and monitoring of subsequent therapy with defibrotide -LRB- DF -RRB- .
15191349	0	PAI-1	74,79	plasminogen_activator_inhibitor-1	39,72	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The prevalence of 4G5G polymorphism of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene in polycystic_ovarian_syndrome and its association with plasma PAI-1 levels .
15673060	0	PAI-1	186,191	plasminogen_activator_inhibitor-1	151,184	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of perindopril treatment on hemostatic function in patients with essential hypertension in relation to angiotensin_converting_enzyme -LRB- ACE -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene polymorphisms .
15745938	0	PAI-1	127,132	plasminogen_activator_inhibitor-1	92,125	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Testosterone does not adversely affect fibrinogen or tissue_plasminogen_activator -LRB- tPA -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels in 46 men with chronic_stable_angina .
15950223	0	PAI-1	123,128	plasminogen_activator_inhibitor-1	88,121	PAI-1	plasminogen activator inhibitor-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Involvement of circadian clock gene Clock in diabetes-induced circadian augmentation of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in the mouse heart .
17848179	0	PAI-1	43,48	plasminogen_activator_inhibitor-1	8,41	PAI-1	plasminogen activator inhibitor-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|END_ENTITY	Chronic plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- overexpression dampens CD25 + lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung .
17848179	0	PAI-1	43,48	plasminogen_activator_inhibitor-1	8,41	PAI-1	plasminogen activator inhibitor-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|END_ENTITY	Chronic plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- overexpression dampens CD25 + lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung .
17938813	0	PAI-1	68,73	plasminogen_activator_inhibitor-1	33,66	PAI-1	plasminogen activator inhibitor-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Food deprivation induces adipose plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice .
17961204	0	PAI-1	176,181	plasminogen_activator_inhibitor-1	141,174	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Fish-oil esters of plant sterols differ from vegetable-oil sterol_esters in triglycerides lowering , carotenoid bioavailability and impact on plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- concentrations in hypercholesterolemic subjects .
19351570	0	PAI-1	40,45	plasminogen_activator_inhibitor-1	47,80	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Prognostic value of pre-surgical plasma PAI-1 -LRB- plasminogen_activator_inhibitor-1 -RRB- levels in breast_cancer .
1960012	0	PAI-1	92,97	plasminogen_activator_inhibitor-1	57,90	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Inverse relationship between cortisol excretion rate and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- antigen and activity in premenopausal_obese women .
19728713	0	PAI-1	84,89	plasminogen_activator_inhibitor-1	49,82	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A citrus extract containing flavanones represses plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression and regulates multiple inflammatory , tissue repair , and fibrosis genes in human colon fibroblasts .
20216986	0	PAI-1	75,80	plasminogen_activator_inhibitor-1	40,73	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The adaptor protein Ruk/CIN85 activates plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression via hypoxia-inducible_factor-1alpha .
22078208	0	PAI-1	92,97	plasminogen_activator_inhibitor-1	57,90	PAI-1	plasminogen activator inhibitor-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Novel regulatory mechanism and functional implication of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in CpG-ODN-stimulated macrophages .
24446892	0	PAI-1	75,80	plasminogen_activator_inhibitor-1	40,73	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The prevalence of 4G/5G polymorphism of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene in central serous_chorioretinopathy and its association with plasma PAI-1 levels .
24596353	0	PAI-1	42,47	plasminogen_activator_inhibitor-1	7,40	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Plasma plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels in breast_cancer - relationship with clinical outcome .
25723084	0	PAI-1	65,70	plasminogen_activator_inhibitor-1	30,63	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 4G/4G polymorphism of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene as an independent risk factor for placental_insufficiency , which triggers fetal hemodynamic centralization .
26456097	0	PAI-1	165,170	plasminogen_activator_inhibitor-1	130,163	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-a induced human aortic endothelial cell migration and decrease plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels .
3142242	0	PAI-1	48,53	plasminogen_activator_inhibitor-1	13,46	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	Reduction|appos|START_ENTITY Reduction|nmod|END_ENTITY	Reduction in plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- with omega-3_polyunsaturated_fatty_acid -LRB- PUFA -RRB- intake .
7740466	0	PAI-1	48,53	plasminogen_activator_inhibitor-1	13,46	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Detection of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- mRNA in human megakaryocytes by in situ hybridization .
8388372	0	PAI-1	108,113	plasminogen_activator_inhibitor-1	73,106	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The two allele sequences of a common polymorphism in the promoter of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene respond differently to interleukin-1 in HepG2 cells .
8571307	0	PAI-1	89,94	plasminogen_activator_inhibitor-1	54,87	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 4G/5G genetic polymorphism in the promoter of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial_infarction in the ECTIM study .
8852783	0	PAI-1	63,68	plasminogen_activator_inhibitor-1	28,61	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	-LSB- Prognostic significance of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- in primary breast_carcinoma -RSB- .
9358004	0	PAI-1	66,71	plasminogen_activator_inhibitor-1	31,64	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differential regulation of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene expression by growth factors and progesterone in human endometrial stromal cells .
9569196	0	PAI-1	77,82	plasminogen_activator_inhibitor-1	42,75	PAI-1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common 4G allele in the promoter of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene as a risk factor for pulmonary_embolism and arterial_thrombosis in hereditary_protein_S_deficiency .
10971410	0	PAI-1	112,117	plasminogen_activator_inhibitor_1	77,110	PAI-1	plasminogen activator inhibitor 1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 4G/4G genotype at nucleotide position -675 in the promotor region of the plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- gene is less frequent in young patients with minor_stroke than in controls .
12506026	0	PAI-1	72,77	plasminogen_activator_inhibitor_1	37,70	PAI-1	plasminogen activator inhibitor 1	5054	5054	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Direct binding of Nur77/NAK -1 to the plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- promoter regulates TNF_alpha - induced PAI-1 expression .
1384159	0	PAI-1	62,67	plasminogen_activator_inhibitor_1	27,60	PAI-1	plasminogen activator inhibitor 1	5054	5054	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Progesterone regulation of plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- antigen and mRNA levels in human endometrial stromal cells .
21719525	0	PAI-1	71,76	plasminogen_activator_inhibitor_1	36,69	PAI-1	plasminogen activator inhibitor 1	5054	5054	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Role of fibrinolytic parameters and plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- promoter polymorphism on premature atherosclerosis in SLE patients .
22038782	0	PAI-1	110,115	plasminogen_activator_inhibitor_1	75,108	PAI-1	plasminogen activator inhibitor 1	5054	5054	Gene	Gene	production|dep|START_ENTITY production|amod|END_ENTITY	Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- production .
17663760	0	PAI-1	53,58	plasminogen_activator_inhibitor_type-1	13,51	PAI-1	plasminogen activator inhibitor type-1	5054	5054	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- by hypoxia and irradiation in human head_and_neck_carcinoma cell lines .
19144865	0	PAI-1	64,69	plasminogen_activator_inhibitor_type-1	24,62	PAI-1	plasminogen activator inhibitor type-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	A profibrotic effect of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- in the heart .
21240498	0	PAI-1	68,73	plasminogen_activator_inhibitor_type-1	28,66	PAI-1	plasminogen activator inhibitor type-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- gene 4G/5G polymorphism and osteoarthritis .
3130610	0	PAI-1	75,80	plasminogen_activator_inhibitor_type-1	35,73	PAI-1	plasminogen activator inhibitor type-1	5054	5054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The regulatory region of the human plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- gene .
8261243	0	PAI-1	69,74	plasminogen_activator_inhibitor_type-1	29,67	PAI-1	plasminogen activator inhibitor type-1	5054	5054	Gene	Gene	biosynthesis|appos|START_ENTITY biosynthesis|nmod|END_ENTITY	Constitutive biosynthesis of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- by cultured human aortic endothelial cells independent of insulin .
17433639	0	PAI-1	82,87	plasminogen_activator_inhibitor_type_1	42,80	PAI-1	plasminogen activator inhibitor type 1	5054	5054	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	C-reactive_protein is directly related to plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene .
24695040	0	PAI-1	64,69	plasminogen_activator_inhibitor_type_1	24,62	PAI-1	plasminogen activator inhibitor type 1	5054	5054	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The association between plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- levels , PAI-1 4G/5G polymorphism , and myocardial_infarction : a Mendelian randomization meta-analysis .
9126661	0	PAI-1	70,75	plasminogen_activator_inhibitor_type_1	30,68	PAI-1	plasminogen activator inhibitor type 1	5054	5054	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Proinsulin-like molecules and plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- activity in diabetic and non-diabetic subjects with and without myocardial_infarction .
9355235	0	PAI-1	83,88	plasminogen_activator_inhibitor_type_1	43,81	PAI-1	plasminogen activator inhibitor type 1	5054	5054	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunoelectron microscopic localization of plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- in smooth muscle cells from morphologically normal and atherosclerotic human arteries .
7828304	0	PAI-1	53,58	proinsulin	63,73	PAI-1	proinsulin	5054	3630	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of plasminogen_activator_inhibitor_type-1 _ -LRB- PAI-1 -RRB- by proinsulin and insulin in vivo .
9737940	0	PAI-1	100,105	proinsulin	115,125	PAI-1	proinsulin	5054	3630	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 -LRB- PAI-1 -RRB- gene by proinsulin and insulin in vivo .
10453514	0	PAI-1	18,23	t-PA	12,16	PAI-1	t-PA	24617(Tax:10116)	25692(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Changes|appos|expression Changes|nmod|END_ENTITY	-LSB- Changes in t-PA , PAI-1 gene expression of coronary arteries with preconditioning in acute myocardial_infarction rat -RSB- .
11208392	0	PAI-1	78,83	t-PA	24,28	PAI-1	t-PA	5054	5327	Gene	Gene	inhibitors|dep|START_ENTITY activators|dobj|inhibitors activators|nsubj|activators activators|dep|END_ENTITY	Plasminogen activators -LRB- t-PA and u-PA -RRB- and plasminogen activators inhibitors -LRB- PAI-1 and PAI-2 -RRB- in some myeloproliferative_syndromes .
1623118	0	PAI-1	91,96	t-PA	39,43	PAI-1	t-PA	5054	5327	Gene	Gene	activators|appos|START_ENTITY activators|dep|END_ENTITY	The release of plasminogen activators -LRB- t-PA and u-PA -RRB- and plasminogen activator inhibitor -LRB- PAI-1 -RRB- after venous_stasis .
1796399	0	PAI-1	0,5	t-PA	135,139	PAI-1	t-PA	5054	5327	Gene	Gene	plays|nsubj|START_ENTITY plays|advcl|controlling controlling|dobj|concentration concentration|nmod|END_ENTITY	PAI-1 plays an important role in the expression of t-PA activity in the euglobulin clot lysis by controlling the concentration of free t-PA .
1796399	0	PAI-1	0,5	t-PA	51,55	PAI-1	t-PA	5054	5327	Gene	Gene	plays|nsubj|START_ENTITY plays|iobj|role role|nmod|expression expression|nmod|activity activity|amod|END_ENTITY	PAI-1 plays an important role in the expression of t-PA activity in the euglobulin clot lysis by controlling the concentration of free t-PA .
1907771	0	PAI-1	54,59	t-PA	100,104	PAI-1	t-PA	5054	5327	Gene	Gene	inhibitor-1|appos|START_ENTITY inhibitor-1|appos|END_ENTITY	Molecular forms of plasminogen activator inhibitor-1 -LRB- PAI-1 -RRB- and tissue-type_plasminogen_activator -LRB- t-PA -RRB- in human plasma .
2500878	0	PAI-1	41,46	t-PA	86,90	PAI-1	t-PA	5054	5327	Gene	Gene	inhibitor|appos|START_ENTITY Quantification|nmod|inhibitor Quantification|appos|END_ENTITY	-LSB- Quantification of a specific inhibitor -LRB- PAI-1 -RRB- of tissue-type plasminogen activator -LRB- t-PA -RRB- in the plasma -RSB- .
2503541	0	PAI-1	60,65	t-PA	129,133	PAI-1	t-PA	5054	5327	Gene	Gene	plasminogen_activator_inhibitor_type_1|appos|START_ENTITY plasminogen_activator_inhibitor_type_1|dep|bound bound|dep|tissue-type_plasminogen_activator tissue-type_plasminogen_activator|appos|END_ENTITY	Interaction between plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- bound to fibrin and either tissue-type_plasminogen_activator -LRB- t-PA -RRB- or urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
2510360	0	PAI-1	27,32	t-PA	50,54	PAI-1	t-PA	5054	5327	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of t-PA free PAI-1 and a complex of t-PA with PAI-1 in human males and females at various ages .
2510360	0	PAI-1	60,65	t-PA	17,21	PAI-1	t-PA	5054	5327	Gene	Gene	t-PA|nmod|START_ENTITY levels|nmod|t-PA levels|nmod|PAI-1 PAI-1|amod|END_ENTITY	Plasma levels of t-PA free PAI-1 and a complex of t-PA with PAI-1 in human males and females at various ages .
3133814	0	PAI-1	105,110	t-PA	68,72	PAI-1	t-PA	5054	5327	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Daytime fluctuations in blood of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and its fast-acting inhibitor -LRB- PAI-1 -RRB- .
7474459	0	PAI-1	94,99	t-PA	49,53	PAI-1	t-PA	5054	5327	Gene	Gene	1|appos|START_ENTITY inhibitor|dobj|1 inhibitor|nsubj|Changes Changes|nmod|activator activator|appos|END_ENTITY	-LSB- Changes in plasma tissue plasminogen activator -LRB- t-PA -RRB- and plasminogen activator inhibitor 1 -LRB- PAI-1 -RRB- by the interferon treatment for chronic hepatitis_C -RSB- .
7740461	0	PAI-1	113,118	t-PA	68,72	PAI-1	t-PA	5054	5327	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	The role of the finger domain of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- in initiation and progression of thrombolysis .
8165591	0	PAI-1	117,122	t-PA	72,76	PAI-1	t-PA	5054	5327	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Effect of isotretinoin on endogenous tissue-type_plasminogen_activator -LRB- t-PA -RRB- and plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- in humans .
8236140	0	PAI-1	34,39	t-PA	61,65	PAI-1	t-PA	24617(Tax:10116)	25692(Tax:10116)	Gene	Gene	resistant|amod|START_ENTITY variant|amod|resistant variant|nmod|END_ENTITY	A slow clearing , fibrin-specific , PAI-1 resistant variant of t-PA -LRB- T103N , KHRR 296-299 AAAA -RRB- .
8569037	0	PAI-1	108,113	t-PA	85,89	PAI-1	t-PA	5054	5327	Gene	Gene	levels|compound|START_ENTITY levels|compound|PAI-1 PAI-1|compound|END_ENTITY	-LSB- Studies on the mechanism of hyperfibrinolysis in liver_cirrhosis -- changes of plasma t-PA , PAI-1 and active PAI-1 levels in liver_cirrhosis -RSB- .
8725727	0	PAI-1	99,104	t-PA	49,53	PAI-1	t-PA	24617(Tax:10116)	25692(Tax:10116)	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Production of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and type-1 plasminogen activator inhibitor -LRB- PAI-1 -RRB- in mildly cirrhotic rat liver .
9184262	0	PAI-1	82,87	t-PA	48,52	PAI-1	t-PA	5054	5327	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Imbalance of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and its specific inhibitor -LRB- PAI-1 -RRB- in patients with rheumatoid_arthritis associated with disease activity .
10390010	0	PAI-1	103,108	tPA	55,58	PAI-1	tPA	5054	5327	Gene	Gene	value|appos|START_ENTITY value|nmod|tissue-type_plasminogen_activator tissue-type_plasminogen_activator|appos|END_ENTITY	Prognostic value of tissue-type_plasminogen_activator -LRB- tPA -RRB- and its complex with the type-1 inhibitor -LRB- PAI-1 -RRB- in breast_cancer .
17689411	0	PAI-1	15,20	tPA	78,81	PAI-1	tPA	5054	5327	Gene	Gene	Association|nmod|START_ENTITY G/A|nsubj|Association G/A|dobj|polymorphism polymorphism|nmod|levels levels|compound|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphism and changes in PAI-1 / tPA levels in stroke : a case-control study .
17689411	0	PAI-1	72,77	tPA	78,81	PAI-1	tPA	5054	5327	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphism and changes in PAI-1 / tPA levels in stroke : a case-control study .
24922319	0	PAI-1	14,19	tPA	53,56	PAI-1	tPA	5054	5327	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers .
26491796	0	PAI-1	30,35	tPA	13,16	PAI-1	tPA	5054	5327	Gene	Gene	degradation|amod|START_ENTITY release|appos|degradation release|compound|END_ENTITY	Overwhelming tPA release , not PAI-1 degradation , is responsible for hyperfibrinolysis in severely injured trauma patients .
10764685	0	PAI-1	144,149	thrombin	123,131	PAI-1	thrombin	5054	2147	Gene	Gene	complexes|compound|START_ENTITY activity|nmod|complexes activity|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
10764685	0	PAI-1	144,149	thrombin	18,26	PAI-1	thrombin	5054	2147	Gene	Gene	complexes|compound|START_ENTITY activity|nmod|complexes mechanism|nmod|activity Colocalization|dep|mechanism Colocalization|nmod|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
12212221	0	PAI-1	84,89	thrombin	11,19	PAI-1	thrombin	5054	2147	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Effect of thrombin on cell proliferation and plasminogen activator inhibitor type -LRB- PAI-1 -RRB- expression in human embryonic glomerular mesangial cells -RSB- .
10390010	0	PAI-1	103,108	tissue-type_plasminogen_activator	20,53	PAI-1	tissue-type plasminogen activator	5054	5327	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of tissue-type_plasminogen_activator -LRB- tPA -RRB- and its complex with the type-1 inhibitor -LRB- PAI-1 -RRB- in breast_cancer .
19929406	0	PAI-1	15,20	tissue_plasminogen_activator	79,107	PAI-1	tissue plasminogen activator	5054	100128998	Gene	Gene	polymorphisms|amod|START_ENTITY Association|nmod|polymorphisms Association|dep|levels levels|compound|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphisms and changes in PAI-1 / tissue_plasminogen_activator levels in myocardial_infarction : a case-control study .
19929406	0	PAI-1	73,78	tissue_plasminogen_activator	79,107	PAI-1	tissue plasminogen activator	5054	100128998	Gene	Gene	polymorphisms|nmod|START_ENTITY Association|nmod|polymorphisms Association|dep|levels levels|compound|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphisms and changes in PAI-1 / tissue_plasminogen_activator levels in myocardial_infarction : a case-control study .
2124638	0	PAI-1	127,132	tissue_plasminogen_activator	41,69	PAI-1	tissue plasminogen activator	5054	100128998	Gene	Gene	antigen|appos|START_ENTITY levels|nmod|antigen -RSB-|nsubj|levels -RSB-|advcl|-LSB- -LSB-|dobj|correlation correlation|nmod|activity activity|nmod|END_ENTITY	-LSB- The correlation between the activity of tissue_plasminogen_activator -LRB- TPA -RRB- , levels of tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- antigen and serum lipids in healthy subjects -RSB- .
2124638	0	PAI-1	127,132	tissue_plasminogen_activator	87,115	PAI-1	tissue plasminogen activator	5054	100128998	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	-LSB- The correlation between the activity of tissue_plasminogen_activator -LRB- TPA -RRB- , levels of tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- antigen and serum lipids in healthy subjects -RSB- .
8965977	0	PAI-1	81,86	tissue_plasminogen_activator	41,69	PAI-1	tissue plasminogen activator	5054	100128998	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	-LSB- Tissue_plasminogen_activator _ -LRB- T-PA -RRB- and tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- in patients after head_injury -RSB- .
9264480	0	PAI-1	171,176	tissue_plasminogen_activator	13,41	PAI-1	tissue plasminogen activator	5054	100128998	Gene	Gene	levels|compound|START_ENTITY patients|nmod|levels relationship|nmod|patients Clearance|dep|relationship Clearance|nmod|END_ENTITY	Clearance of tissue_plasminogen_activator -LRB- TPA -RRB- and TPA/plasminogen _ activator_inhibitor_type_1 -LRB- PAI-1 -RRB- complex : relationship to elevated TPA antigen in patients with high PAI-1 activity levels .
16279946	0	PAI-1	13,18	tumor_necrosis_factor_alpha	33,60	PAI-1	tumor necrosis factor alpha	5054	7124	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of PAI-1 expression by tumor_necrosis_factor_alpha in endothelial cells is mediated by its responsive element located in the 4G/5G site .
10764685	0	PAI-1	144,149	vitronectin	150,161	PAI-1	vitronectin	5054	7448	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
11266468	0	PAI-1	36,41	vitronectin	116,127	PAI-1	vitronectin	5054	7448	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|interaction interaction|nmod|proteases proteases|appos|END_ENTITY	The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases , not vitronectin .
11400167	0	PAI-1	60,65	vitronectin	39,50	PAI-1	vitronectin	5054	7448	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Human endothelial cells grow poorly on vitronectin : role of PAI-1 .
12437099	0	PAI-1	114,119	vitronectin	67,78	PAI-1	vitronectin	5054	7448	Gene	Gene	mapping|nmod|START_ENTITY Interaction|parataxis|mapping Interaction|nmod|PAI-1 PAI-1|nmod|END_ENTITY	Interaction of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- with vitronectin -LRB- Vn -RRB- : mapping the binding sites on PAI-1 and Vn .
12808446	0	PAI-1	22,27	vitronectin	4,15	PAI-1	vitronectin	5054	7448	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration .
1721912	0	PAI-1	56,61	vitronectin	86,97	PAI-1	vitronectin	5054	7448	Gene	Gene	plasminogen_activator_inhibitor_1|appos|START_ENTITY plasminogen_activator_inhibitor_1|acl:relcl|complexed complexed|nmod|END_ENTITY	Thrombin neutralizes plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- that is complexed with vitronectin in the endothelial cell matrix .
22700714	0	PAI-1	15,20	vitronectin	70,81	PAI-1	vitronectin	5054	7448	Gene	Gene	uPA|amod|START_ENTITY induces|nsubj|uPA induces|dobj|differentiation differentiation|nmod|END_ENTITY	uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin .
2467912	0	PAI-1	48,53	vitronectin	60,71	PAI-1	vitronectin	5054	7448	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of plasminogen activator inhibitor -LRB- PAI-1 -RRB- with vitronectin .
2470735	1	PAI-1	173,178	vitronectin	182,193	PAI-1	vitronectin	5054	7448	Gene	Gene	binding|nmod|START_ENTITY Demonstration|nmod|binding Demonstration|nmod|END_ENTITY	Demonstration of the binding , stabilization , and activation of PAI-1 by vitronectin .
7522053	0	PAI-1	20,25	vitronectin	42,53	PAI-1	vitronectin	5054	7448	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Identification of a PAI-1 binding site in vitronectin .
7523190	0	PAI-1	84,89	vitronectin	21,32	PAI-1	vitronectin	5054	7448	Gene	Gene	plasminogen_activator_inhibitor_1|appos|START_ENTITY site|nmod|plasminogen_activator_inhibitor_1 site|compound|END_ENTITY	Determination of the vitronectin binding site on plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- .
8837777	0	PAI-1	11,16	vitronectin	88,99	PAI-1	vitronectin	5054	7448	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|blocking blocking|nmod|END_ENTITY	The serpin PAI-1 inhibits cell migration by blocking integrin_alpha_V_beta_3 binding to vitronectin .
10469140	0	PAI-2	40,45	Plasminogen_activator_inhibitor_type-2	0,38	PAI-2	Plasminogen activator inhibitor type-2	5055	5055	Gene	Gene	requires|dep|START_ENTITY requires|nsubj|END_ENTITY	Plasminogen_activator_inhibitor_type-2 -LRB- PAI-2 -RRB- gene transcription requires a novel NF-kappaB-like transcriptional regulatory motif .
10411006	0	PAI-2	53,58	plasminogen_activator_inhibitor-2	18,51	PAI-2	plasminogen activator inhibitor-2	18788(Tax:10090)	18788(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of the plasminogen_activator_inhibitor-2 -LRB- PAI-2 -RRB- gene in murine macrophages .
12225871	0	PAI-2	127,132	plasminogen_activator_inhibitor-2	92,125	PAI-2	plasminogen activator inhibitor-2	18788(Tax:10090)	18788(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Plasminogen mRNA induction in the mouse brain after kainate excitation : codistribution with plasminogen_activator_inhibitor-2 -LRB- PAI-2 -RRB- mRNA .
20494554	0	PAI-2	43,48	plasminogen_activator_inhibitor-2	8,41	PAI-2	plasminogen activator inhibitor-2	5055	5055	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of plasminogen_activator_inhibitor-2 -LRB- PAI-2 -RRB- in keratinocyte differentiation .
9241752	0	PAI-2	72,77	plasminogen_activator_inhibitor_2	37,70	PAI-2	plasminogen activator inhibitor 2	5055	5055	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation , location and activity of plasminogen_activator_inhibitor_2 -LRB- PAI-2 -RRB- in peripheral blood monocytes , macrophages and foam cells .
10075998	0	PAI-2	77,82	plasminogen_activator_inhibitor_type_2	37,75	PAI-2	plasminogen activator inhibitor type 2	5055	5055	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	An AU-rich sequence in the 3 ' - UTR of plasminogen_activator_inhibitor_type_2 -LRB- PAI-2 -RRB- mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR .
9037208	0	PAI-2	82,87	plasminogen_activator_inhibitor_type_2	42,80	PAI-2	plasminogen activator inhibitor type 2	5055	5055	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Urokinase-mediated transactivation of the plasminogen_activator_inhibitor_type_2 -LRB- PAI-2 -RRB- gene promoter in HT-1080 cells utilises AP-1 binding sites and potentiates phorbol_ester-mediated induction of endogenous PAI-2 mRNA .
9780231	0	PAI-2	108,113	plasminogen_activator_inhibitor_type_2	68,106	PAI-2	plasminogen activator inhibitor type 2	5055	5055	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNase I hypersensitive sites in the 5 ' flanking region of the human plasminogen_activator_inhibitor_type_2 -LRB- PAI-2 -RRB- gene are associated with basal and tumor_necrosis_factor-alpha-induced transcription in monocytes .
15471851	0	PAK-2	88,93	PS-GAP	39,45	PAK-2	PS-GAP	5062	79658	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2 .
23554696	0	PAK1	76,80	Akt	24,27	PAK1	Akt	5058	207	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Activation of Rac1-PI3K / Akt is required for epidermal_growth_factor-induced PAK1 activation and cell migration in MDA-MB-231 breast_cancer cells .
22945935	0	PAK1	29,33	CYK4	0,4	PAK1	CYK4	5058	29127	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis .
23213466	0	PAK1	70,74	E-Syt2	22,28	PAK1	E-Syt2	5058	57488	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The endocytic adapter E-Syt2 recruits the p21 GTPase activated kinase PAK1 to mediate actin dynamics and FGF signalling .
12876277	0	PAK1	0,4	MEK1	24,28	PAK1	MEK1	5058	5604	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation .
26884926	0	PAK1	101,105	MiR-98	0,6	PAK1	MiR-98	5058	407054	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-98 inhibits cell proliferation and invasion of non-small_cell_carcinoma_lung_cancer by targeting PAK1 .
15684429	0	PAK1	0,4	NET1	66,70	PAK1	NET1	5058	10276	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	PAK1 negatively regulates the activity of the Rho exchange factor NET1 .
19136554	0	PAK1	32,36	Trihydrophobin_1	0,16	PAK1	Trihydrophobin 1	5058	51497	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	Trihydrophobin_1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration .
18515095	0	PAK1	0,4	beta-catenin	20,32	PAK1	beta-catenin	5058	1499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins .
24954107	0	PAK1	63,67	miR-145	0,7	PAK1	miR-145	5058	406937	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-145 inhibits invasion of bladder_cancer cells by targeting PAK1 .
9298982	0	PAK1	40,44	p21-activated_kinase_1	16,38	PAK1	p21-activated kinase 1	29431(Tax:10116)	29431(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of p21-activated_kinase_1 -LRB- PAK1 -RRB- to pinocytic vesicles and cortical actin structures in stimulated cells .
23340249	0	PAK1	23,27	prolactin	81,90	PAK1	prolactin	5058	5617	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Tyrosyl phosphorylated PAK1 regulates breast_cancer cell motility in response to prolactin through filamin_A .
19359598	0	PAK1	47,51	thrombin	24,32	PAK1	thrombin	5058	2147	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	A role for Gab1/SHP2 in thrombin activation of PAK1 : gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis .
17555715	0	PAK2	18,22	MUC5AC	60,66	PAK2	MUC5AC	5062	4586	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF .
14612425	0	PAK2	33,37	Smad2	88,93	PAK2	Smad2	5062	4087	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Cell-type-specific activation of PAK2 by transforming_growth_factor_beta independent of Smad2 and Smad3 .
26186482	0	PAK2	62,66	miR-137	0,7	PAK2	miR-137	5062	406928	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-137 inhibits proliferation of melanoma cells by targeting PAK2 .
17555715	0	PAK2	18,22	mucin	67,72	PAK2	mucin	5062	100508689	Gene	Gene	roles|nmod|START_ENTITY roles|acl|END_ENTITY	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF .
10748018	0	PAK2	69,73	myosin_light_chain_kinase	19,44	PAK2	myosin light chain kinase	5062	4638	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of myosin_light_chain_kinase by p21-activated kinase PAK2 .
25109462	0	PAK3	107,111	Cdc42Hs	54,61	PAK3	Cdc42Hs	5063	998	Gene	Gene	Domain|nmod|START_ENTITY END_ENTITY|nmod|Domain	Dynamic and Thermodynamic Response of the Ras Protein Cdc42Hs upon Association with the Effector Domain of PAK3 .
18805672	0	PAK3	45,49	P21-activated_kinase_3	21,43	PAK3	P21-activated kinase 3	5063	5063	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Sequence analysis of P21-activated_kinase_3 -LRB- PAK3 -RRB- in chronic schizophrenia with cognitive_impairment .
21949127	0	PAK3	24,28	p21-Activated_kinase_3	0,22	PAK3	p21-Activated kinase 3	5063	5063	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	p21-Activated_kinase_3 -LRB- PAK3 -RRB- protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor .
20631255	0	PAK4	86,90	Cdc42	0,5	PAK4	Cdc42	10298	998	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B .
19778628	0	PAK4	16,20	DGCR6L	0,6	PAK4	DGCR6L	10298	85359	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	DGCR6L , a novel PAK4 interaction protein , regulates PAK4-mediated migration of human gastric_cancer cell via LIMK1 .
26607847	0	PAK4	35,39	Inka1	70,75	PAK4	Inka1	10298	389119	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1 .
22766504	0	PAK4	18,22	MiR-145	0,7	PAK4	MiR-145	10298	406937	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells .
26137045	0	PAK4	24,28	microRNA-126	0,12	PAK4	microRNA-126	10298	406913	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	microRNA-126 suppresses PAK4 expression in ovarian_cancer SKOV3 cells .
25705811	0	PAK4	129,133	p21-activated_kinase_4	105,127	PAK4	p21-activated kinase 4	10298	10298	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Design , synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated_kinase_4 -LRB- PAK4 -RRB- inhibitors .
26375402	0	PAK6	21,25	LRRK2	0,5	PAK6	LRRK2	56924	120892	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LRRK2 interacts with PAK6 to control neurite complexity in mammalian brain .
26093023	0	PAL	40,43	PHENYLALANINE_AMMONIA_LYASE	11,38	PAL	PHENYLALANINE AMMONIA LYASE	100829928	100829928	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of PHENYLALANINE_AMMONIA_LYASE -LRB- PAL -RRB- knockdown on cell wall composition , biomass digestibility , and biotic and abiotic stress responses in Brachypodium .
24301035	0	PAL	47,50	phenylalanine_ammonia-lyase	18,45	PAL	phenylalanine ammonia-lyase	543380(Tax:4565)	543380(Tax:4565)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The estimation of phenylalanine_ammonia-lyase -LRB- PAL -RRB- activity in intact cells of higher plant tissue : III .
19268590	0	PALB2	0,5	BRCA1	12,17	PALB2	BRCA1	79728	672	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	PALB2 links BRCA1 and BRCA2 in the DNA-damage response .
21356067	0	PALB2	35,40	BRCA1	14,19	PALB2	BRCA1	79728	672	Gene	Gene	RAD50|appos|START_ENTITY RAD50|compound|END_ENTITY	Screening for BRCA1 , BRCA2 , CHEK2 , PALB2 , BRIP1 , RAD50 , and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast_and / or_ovarian_cancer individuals .
19609323	0	PALB2	45,50	BRCA2	36,41	PALB2	BRCA2	79728	675	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recruitment of BRCA2 by PALB2 .
22331464	0	PALB2	0,5	KEAP1	21,26	PALB2	KEAP1	79728	9817	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function .
20332121	0	PALB2	24,29	MRG15	0,5	PALB2	MRG15	79728	10933	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks .
25113031	0	PALB2	28,33	RPA	15,18	PALB2	RPA	79728	6117	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery .
8187161	0	PAM	47,50	Peptidylglycine_alpha-amidating_monooxygenase	0,45	PAM	Peptidylglycine alpha-amidating monooxygenase	5066	5066	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary_tumours .
10639739	0	PAM	82,85	peptidylglycine_alpha-amidating_monooxygenase	35,80	PAM	peptidylglycine alpha-amidating monooxygenase	25508(Tax:10116)	25508(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Characterization and regulation of peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- expression in H9c2 cardiac myoblasts .
2925636	0	PAM	75,78	peptidylglycine_alpha-amidating_monooxygenase	28,73	PAM	peptidylglycine alpha-amidating monooxygenase	25508(Tax:10116)	25508(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Developmental regulation of peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- in rat heart atrium and ventricle .
8288234	0	PAM	81,84	peptidylglycine_alpha-amidating_monooxygenase	34,79	PAM	peptidylglycine alpha-amidating monooxygenase	5066	5066	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the gene encoding peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- to human chromosome 5q14-5q21 .
20108251	0	PAM14	27,32	Sedlin	15,21	PAM14	Sedlin	93621	6399	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Sedlin with PAM14 .
12667619	0	PAMP	21,25	PAMP	83,87	PAMP	PAMP	133	133	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Paracrine effects of PAMP and adrenomedullin on the human adrenal H295R cell line : PAMP but not adrenomedullin stimulates DHEA secretion .
12667619	0	PAMP	83,87	PAMP	21,25	PAMP	PAMP	133	133	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Paracrine effects of PAMP and adrenomedullin on the human adrenal H295R cell line : PAMP but not adrenomedullin stimulates DHEA secretion .
10562449	0	PAMP	41,45	Proadrenomedullin_N-terminal_20_peptide	0,39	PAMP	Proadrenomedullin N-terminal 20 peptide	133	133	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Proadrenomedullin_N-terminal_20_peptide -LRB- PAMP -RRB- immunoreactivity in vertebrate juxtaglomerular granular cells identified by both light and electron microscopy .
26123584	0	PANDER	75,81	PANcreatic-DERived_factor	48,73	PANDER	PANcreatic-DERived factor	52793(Tax:10090)	52793(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Hepatic nutrient and hormonal regulation of the PANcreatic-DERived_factor -LRB- PANDER -RRB- promoter .
20844005	0	PANDER	60,66	pancreatic-derived_factor	33,58	PANDER	pancreatic-derived factor	52793(Tax:10090)	52793(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Liver-specific overexpression of pancreatic-derived_factor -LRB- PANDER -RRB- induces fasting hyperglycemia in mice .
26123584	0	PANcreatic-DERived_factor	48,73	PANDER	75,81	PANcreatic-DERived factor	PANDER	52793(Tax:10090)	52793(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Hepatic nutrient and hormonal regulation of the PANcreatic-DERived_factor -LRB- PANDER -RRB- promoter .
23219533	0	PAP	16,19	PARP1	0,5	PAP	PARP1	10914	142	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	PARP1 represses PAP and inhibits polyadenylation during heat_shock .
23825434	0	PAP	62,65	Tissue-nonspecific_alkaline_phosphatase	0,39	PAP	Tissue-nonspecific alkaline phosphatase	56318(Tax:10090)	11647(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Tissue-nonspecific_alkaline_phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord .
12757156	0	PAP	51,54	pancreatitis-associated_protein	18,49	PAP	pancreatitis-associated protein	5068	5068	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of pancreatitis-associated_protein -LRB- PAP -RRB- in human pancreatic_ductal_adenocarcinoma .
8188210	0	PAP	116,119	pancreatitis-associated_protein	83,114	PAP	pancreatitis-associated protein	5068	5068	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning , genomic organization , and chromosomal localization of the human pancreatitis-associated_protein -LRB- PAP -RRB- gene .
8241280	0	PAP	71,74	pancreatitis_associated_protein_III	4,39	PAP	pancreatitis associated protein III	24618(Tax:10116)	24620(Tax:10116)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	The pancreatitis_associated_protein_III -LRB- PAP_III -RRB- , a new member of the PAP gene family .
12174291	0	PAP1	59,63	PHO85	34,39	PAP1	PHO85	853871(Tax:4932)	856076(Tax:4932)	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Cloning and Expression of a Novel PHO85 Associated Protein PAP1 Gene of Saccharomyces_cerevisiae .
18408767	0	PAPC	28,32	PCDH8	0,5	PAPC	PCDH8	5100	5100	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	PCDH8 , the human homolog of PAPC , is a candidate tumor suppressor of breast_cancer .
22503545	0	PAPP-A	0,6	ABCA1	28,33	PAPP-A	ABCA1	5069	19	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PAPP-A negatively regulates ABCA1 , ABCG1 and SR-B1 expression by inhibiting LXRa through the IGF-I-mediated signaling pathway .
22997483	0	PAPP-A	26,32	CRP	0,3	PAPP-A	CRP	5069	1401	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	CRP and TNF-a induce PAPP-A expression in human peripheral blood mononuclear cells .
25286675	0	PAPP-A	15,21	IGF-I	114,119	PAPP-A	IGF-I	5069	3479	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	-LSB- Expression of PAPP-A , IGF-I and their effects on the cytological functions of siRNA lentiviral vector of hCASMCs IGF-I after inflammatory factor -RSB- .
22503545	0	PAPP-A	0,6	LXRa	76,80	PAPP-A	LXRa	5069	10062	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|dobj|END_ENTITY	PAPP-A negatively regulates ABCA1 , ABCG1 and SR-B1 expression by inhibiting LXRa through the IGF-I-mediated signaling pathway .
16388849	0	PAPP-A	14,20	PPARgamma	35,44	PAPP-A	PPARgamma	5069	5468	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression Modulation|nmod|END_ENTITY	Modulation of PAPP-A expression by PPARgamma in human first trimester trophoblast .
15146551	0	PAPP-A	39,45	Pregnancy-associated_plasma_protein-A	0,37	PAPP-A	Pregnancy-associated plasma protein-A	5069	5069	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- expression and insulin-like_growth_factor_binding_protein-4 protease activity in normal and malignant ovarian surface epithelial cells .
25573795	0	PAPP-A	23,29	S100-B	15,21	PAPP-A	S100-B	5069	6285	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Maternal Serum S100-B , PAPP-A and IL-6 levels in severe preeclampsia .
2420292	0	PAPP-A	50,56	pregnancy-associated_plasma_protein-A	11,48	PAPP-A	pregnancy-associated plasma protein-A	5069	5069	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- to placental subfractions .
2420432	0	PAPP-A	80,86	pregnancy-associated_plasma_protein-A	41,78	PAPP-A	pregnancy-associated plasma protein-A	5069	5069	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Circulating and tissue concentrations of pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- in tubal ectopic gestation .
2438194	0	PAPP-A	53,59	pregnancy-associated_plasma_protein-A	14,51	PAPP-A	pregnancy-associated plasma protein-A	5069	5069	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- by cultured tumour granulosa cells .
23401929	0	PAPP-A	55,61	pregnancy-associated_plasma_protein_A	16,53	PAPP-A	pregnancy-associated plasma protein A	5069	5069	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of pregnancy-associated_plasma_protein_A -LRB- PAPP-A -RRB- concentration determination in the assessment of final outcome of pregnancy .
6191321	0	PAPP-A	56,62	pregnancy-associated_plasma_protein_A	17,54	PAPP-A	pregnancy-associated plasma protein A	5069	5069	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of pregnancy-associated_plasma_protein_A -LRB- PAPP-A -RRB- in patients with pre-eclamptic_toxaemia .
6209702	0	PAPP-A	75,81	pregnancy-associated_plasma_protein_A	36,73	PAPP-A	pregnancy-associated plasma protein A	5069	5069	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of pregnancy-associated_plasma_protein_A -LRB- PAPP-A -RRB- in placentae from normal and pre-eclamptic pregnancies .
7684253	0	PAPP-A	68,74	pregnancy_associated_plasma_protein_A	29,66	PAPP-A	pregnancy associated plasma protein A	5069	5069	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Low maternal serum levels of pregnancy_associated_plasma_protein_A -LRB- PAPP-A -RRB- in the first trimester in association with abnormal fetal karyotype .
21496272	0	PAPPA2	54,60	pregnancy-associated_plasma_protein_A2	14,52	PAPPA2	pregnancy-associated plasma protein A2	60676	60676	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of pregnancy-associated_plasma_protein_A2 -LRB- PAPPA2 -RRB- in a human placental trophoblast cell line -LRB- BeWo -RRB- .
15777617	0	PAP_IB	0,6	Reg	28,31	PAP IB	Reg	130120	5967	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	PAP_IB , a new member of the Reg gene family : cloning , expression , structural properties , and evolution by gene duplication .
11516655	0	PAR-1	36,41	Bazooka	0,7	PAR-1	Bazooka	2768852(Tax:7227)	32703(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila .
18507028	0	PAR-1	51,56	MMP-1	90,95	PAR-1	MMP-1	2149	4312	Gene	Gene	protease-activated_receptor-1|appos|START_ENTITY protease-activated_receptor-1|appos|END_ENTITY	Prognostic value of protease-activated_receptor-1 -LRB- PAR-1 -RRB- and matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- in gastric_cancer .
21966428	0	PAR-1	103,108	MMP-1	142,147	PAR-1	MMP-1	2149	4312	Gene	Gene	protease-activated_receptor-1|appos|START_ENTITY protease-activated_receptor-1|appos|END_ENTITY	Galectin-3 facilitates cell motility in gastric_cancer by up-regulating protease-activated_receptor-1 -LRB- PAR-1 -RRB- and matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- .
22086466	0	PAR-1	6,11	MMP-1	0,5	PAR-1	MMP-1	2149	4312	Gene	Gene	signal|nsubj|START_ENTITY END_ENTITY|appos|signal	MMP-1 / PAR-1 signal transduction axis and its prognostic impact in esophageal_squamous_cell_carcinoma .
26170698	0	PAR-1	20,25	MMP-1	14,19	PAR-1	MMP-1	2149	4312	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of MMP-1 / PAR-1 and patterns of invasion in oral_squamous_cell_carcinoma as potential prognostic markers .
26783471	0	PAR-1	10,15	MMP-1	4,9	PAR-1	MMP-1	14062(Tax:10090)	17386(Tax:10090)	Gene	Gene	Proliferation|compound|START_ENTITY Cells|nsubj|Proliferation END_ENTITY|parataxis|Cells	The MMP-1 / PAR-1 Axis Enhances Proliferation and Neuronal Differentiation of Adult Hippocampal Neural Progenitor Cells .
19686683	0	PAR-1	0,5	Mind_bomb	21,30	PAR-1	Mind bomb	145624	57534	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	PAR-1 phosphorylates Mind_bomb to promote vertebrate neurogenesis .
10664248	0	PAR-1	24,29	PAR-4	30,35	PAR-1	PAR-4	2149	9002	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	The two-receptor system PAR-1 / PAR-4 mediates alpha-thrombin-induced -LSB- Ca -LRB- 2 + -RRB- -RSB- -LRB- i -RRB- mobilization in human astrocytoma cells .
19531360	0	PAR-1	47,52	PP2A	0,4	PAR-1	PP2A	145624	5524	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts .
18612544	0	PAR-1	31,36	Protease_activated_receptor_1	0,29	PAR-1	Protease activated receptor 1	2149	2149	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Protease_activated_receptor_1 -LRB- PAR-1 -RRB- activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial_protein_C_receptor is occupied by its natural ligand .
12052165	0	PAR-1	50,55	Thrombin	0,8	PAR-1	Thrombin	2149	2147	Gene	Gene	development|compound|START_ENTITY advances|nmod|development antagonists|dep|advances antagonists|amod|END_ENTITY	Thrombin receptor antagonists ; recent advances in PAR-1 antagonist development .
18571697	0	PAR-1	74,79	Thrombin	0,8	PAR-1	Thrombin	2149	2147	Gene	Gene	pathways|amod|START_ENTITY synthesis|nmod|pathways vascular|dobj|synthesis regulates|xcomp|vascular regulates|nsubj|END_ENTITY	Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways .
20144050	0	PAR-1	19,24	Thrombin	0,8	PAR-1	Thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Thrombin receptor -LRB- PAR-1 -RRB- antagonists as novel antithrombotic agents .
20506163	0	PAR-1	167,172	Thrombin	0,8	PAR-1	Thrombin	2149	2147	Gene	Gene	activation|nmod|START_ENTITY down-regulates|nmod|activation down-regulates|nsubj|END_ENTITY	Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1 .
22212430	0	PAR-1	104,109	Thrombin	0,8	PAR-1	Thrombin	25439(Tax:10116)	29251(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY cells|dep|expression expression|compound|END_ENTITY	Thrombin induced connective_tissue_growth_factor expression in rat vascular smooth muscle cells via the PAR-1 / JNK/AP -1 pathway .
23919450	0	PAR-1	55,60	Thrombin	0,8	PAR-1	Thrombin	2149	2147	Gene	Gene	transition|nmod|START_ENTITY pathways|nsubj|transition induces|ccomp|pathways induces|nsubj|END_ENTITY	Thrombin induces epithelial-mesenchymal transition via PAR-1 , PKC , and ERK1/2 pathways in A549 cells .
9493599	0	PAR-1	83,88	Thrombin	0,8	PAR-1	Thrombin	25439(Tax:10116)	29251(Tax:10116)	Gene	Gene	mediated|amod|START_ENTITY mechanism|amod|mediated synthesis|nmod|mechanism stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism .
22212430	0	PAR-1	104,109	connective_tissue_growth_factor	17,48	PAR-1	connective tissue growth factor	25439(Tax:10116)	64032(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY cells|dep|expression expression|compound|END_ENTITY	Thrombin induced connective_tissue_growth_factor expression in rat vascular smooth muscle cells via the PAR-1 / JNK/AP -1 pathway .
16231009	0	PAR-1	127,132	mesotrypsin	88,99	PAR-1	mesotrypsin	2149	5646	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Activity of recombinant trypsin isoforms on human proteinase-activated receptors -LRB- PAR -RRB- : mesotrypsin can not activate epithelial PAR-1 , -2 , but weakly activates brain PAR-1 .
9105886	0	PAR-1	65,70	protease-activated_receptor	36,63	PAR-1	protease-activated receptor	25439(Tax:10116)	25439(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Pharmacological characterization of protease-activated_receptor -LRB- PAR-1 -RRB- in rat astrocytes .
11015310	0	PAR-1	173,178	thrombin	19,27	PAR-1	thrombin	25439(Tax:10116)	29251(Tax:10116)	Gene	Gene	muscularis|nmod|START_ENTITY muscularis|nsubj|modulation modulation|nmod|END_ENTITY	Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors -LRB- PARs -RRB- : a novel role for PAR-4 as opposed to PAR-1 .
11360179	0	PAR-1	23,28	thrombin	4,12	PAR-1	thrombin	14062(Tax:10090)	14061(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The thrombin receptor , PAR-1 , causes transformation by activation of Rho-mediated signaling pathways .
11591503	0	PAR-1	101,106	thrombin	82,90	PAR-1	thrombin	2149	2147	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor -LRB- PAR-1 -RRB- antagonists .
11672764	0	PAR-1	79,84	thrombin	89,97	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY degradation|nmod|receptor inhibits|dobj|degradation inhibits|nmod|END_ENTITY	Aptamer inhibits degradation of platelet proteolytically activatable receptor , PAR-1 , by thrombin .
14961162	0	PAR-1	153,158	thrombin	134,142	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|due due|nmod|cleavage cleavage|nmod|END_ENTITY	Platelets in patients with acute ischemic_stroke are exhausted and refractory to thrombin , due to cleavage of the seven-transmembrane thrombin receptor -LRB- PAR-1 -RRB- .
14961162	0	PAR-1	153,158	thrombin	81,89	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Platelets in patients with acute ischemic_stroke are exhausted and refractory to thrombin , due to cleavage of the seven-transmembrane thrombin receptor -LRB- PAR-1 -RRB- .
15317288	0	PAR-1	112,117	thrombin	62,70	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Discovery of potent peptide-mimetic antagonists for the human thrombin receptor , protease-activated_receptor-1 -LRB- PAR-1 -RRB- .
18005014	0	PAR-1	62,67	thrombin	12,20	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY gene|dep|receptor gene|compound|END_ENTITY	Effect of a thrombin receptor -LRB- protease-activated receptor 1 , PAR-1 -RRB- gene polymorphism in chronic hepatitis_C liver_fibrosis .
18570113	0	PAR-1	42,47	thrombin	23,31	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Over-expression of the thrombin receptor -LRB- PAR-1 -RRB- in the placenta in preeclampsia : a mechanism for the intersection of coagulation and inflammation .
18612544	0	PAR-1	31,36	thrombin	52,60	PAR-1	thrombin	2149	2147	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Protease_activated_receptor_1 -LRB- PAR-1 -RRB- activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial_protein_C_receptor is occupied by its natural ligand .
19705342	0	PAR-1	33,38	thrombin	14,22	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	SCH-530348 , a thrombin receptor -LRB- PAR-1 -RRB- antagonist for the prevention and treatment of atherothrombosis .
19882073	0	PAR-1	156,161	thrombin	113,121	PAR-1	thrombin	2149	2147	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|receptor receptor|compound|END_ENTITY	Improving antiplatelet therapy for atherothrombotic_disease : preclinical results with SCH_530348 , the first oral thrombin receptor antagonist selective for PAR-1 .
24435325	0	PAR-1	59,64	thrombin	15,23	PAR-1	thrombin	2149	2147	Gene	Gene	regulation|compound|START_ENTITY potential|nmod|regulation potential|compound|END_ENTITY	Association of thrombin generation potential with platelet PAR-1 regulation and P-selectin expression in patients on dual antiplatelet therapy .
9308764	0	PAR-1	34,39	thrombin	101,109	PAR-1	thrombin	2149	2147	Gene	Gene	Release|appos|START_ENTITY N-terminus|nsubj|Release N-terminus|nmod|surface surface|nmod|platelets platelets|acl|activated activated|nmod|END_ENTITY	Release of the thrombin receptor -LRB- PAR-1 -RRB- N-terminus from the surface of human platelets activated by thrombin .
9308764	0	PAR-1	34,39	thrombin	15,23	PAR-1	thrombin	2149	2147	Gene	Gene	Release|appos|START_ENTITY Release|nmod|receptor receptor|compound|END_ENTITY	Release of the thrombin receptor -LRB- PAR-1 -RRB- N-terminus from the surface of human platelets activated by thrombin .
9486128	0	PAR-1	83,88	thrombin	64,72	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Protein kinase C beta regulates heterologous desensitization of thrombin receptor -LRB- PAR-1 -RRB- in endothelial cells .
9721728	0	PAR-1	75,80	thrombin	56,64	PAR-1	thrombin	2149	2147	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Injury-related factors and conditions down-regulate the thrombin receptor -LRB- PAR-1 -RRB- in a human neuronal cell line .
9886918	0	PAR-1	71,76	thrombin	52,60	PAR-1	thrombin	2149	2147	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Time course of recovery of endothelial cell surface thrombin receptor -LRB- PAR-1 -RRB- expression .
11598900	0	PAR-1	37,42	thrombin_receptor	18,35	PAR-1	thrombin receptor	25439(Tax:10116)	25439(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the thrombin_receptor -LRB- PAR-1 -RRB- during rat skeletal muscle differentiation .
11733402	0	PAR-1	111,116	thrombin_receptor	92,109	PAR-1	thrombin receptor	25439(Tax:10116)	25439(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin_receptor -LRB- PAR-1 -RRB- expression : role of the glucocorticoid receptor .
17224403	0	PAR-1_kinase	0,12	Dlg	28,31	PAR-1 kinase	Dlg	2768852(Tax:7227)	32083(Tax:7227)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	PAR-1_kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction .
17075267	0	PAR-2	0,5	CD4	16,19	PAR-2	CD4	109447(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
11930172	0	PAR-2	40,45	Fos	30,33	PAR-2	Fos	116677(Tax:10116)	314322(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY expression|nmod|stimulation expression|nmod|END_ENTITY	Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats .
17075267	0	PAR-2	0,5	IFN-gamma	80,89	PAR-2	IFN-gamma	109447(Tax:10090)	15978(Tax:10090)	Gene	Gene	T|compound|START_ENTITY cells|nsubj|T cells|dobj|downregulation downregulation|nmod|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
17075267	0	PAR-2	0,5	IL-4	55,59	PAR-2	IL-4	109447(Tax:10090)	16189(Tax:10090)	Gene	Gene	T|compound|START_ENTITY cells|nsubj|T cells|dobj|downregulation downregulation|nmod|END_ENTITY	PAR-2 deficient CD4 + T cells exhibit downregulation of IL-4 and upregulation of IFN-gamma after antigen challenge in mice .
15070680	0	PAR-2	103,108	IL-8	52,56	PAR-2	IL-8	2150	3576	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration .
17581194	0	PAR-2	0,5	IL-8	27,31	PAR-2	IL-8	2150	3576	Gene	Gene	activation|compound|START_ENTITY regulates|nsubj|activation regulates|dobj|synthesis synthesis|compound|END_ENTITY	PAR-2 activation regulates IL-8 and GRO-alpha synthesis by NF-kappaB , but not RANTES , IL-6 , eotaxin or TARC expression in nasal epithelium .
19889021	0	PAR-2	95,100	IL-8	85,89	PAR-2	IL-8	2150	3576	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation .
15482468	0	PAR-2	31,36	Protease-activated_receptor-2	0,29	PAR-2	Protease-activated receptor-2	2150	2150	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Protease-activated_receptor-2 -LRB- PAR-2 -RRB- expression in human fibroblasts is regulated by growth factors and extracellular matrix .
23764046	0	PAR-2	10,15	TGF-a	82,87	PAR-2	TGF-a	2150	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Activated PAR-2 regulates pancreatic_cancer progression through ILK/HIF-a-induced TGF-a expression and MEK/VEGF-A-mediated angiogenesis .
19852794	0	PAR-2	37,42	TGF-beta	0,8	PAR-2	TGF-beta	2150	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells .
19263271	0	PAR-2	45,50	protease-activated-receptor_2	14,43	PAR-2	protease-activated-receptor 2	2150	2150	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of protease-activated-receptor_2 -LRB- PAR-2 -RRB- in human esophageal mucosa .
20412704	0	PAR-2	70,75	protease-activated_receptor-2	39,68	PAR-2	protease-activated receptor-2	2150	2150	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	The role of proteinase_3 -LRB- PR3 -RRB- and the protease-activated_receptor-2 -LRB- PAR-2 -RRB- pathway in dendritic cell -LRB- DC -RRB- maturation of human-DC-like monocytes and murine DC .
11828045	0	PAR-2	45,50	protease_activated_receptor-2	14,43	PAR-2	protease activated receptor-2	2150	2150	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of protease_activated_receptor-2 -LRB- PAR-2 -RRB- in central airways of smokers and non-smokers .
16425301	0	PAR-2	45,50	protease_activated_receptor-2	14,43	PAR-2	protease activated receptor-2	2150	2150	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of protease_activated_receptor-2 -LRB- PAR-2 -RRB- in gastric_cancer .
15537383	0	PAR-2	58,63	serine_protease	22,37	PAR-2	serine protease	2150	2147	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The membrane-anchored serine_protease , TMPRSS2 , activates PAR-2 in prostate_cancer cells .
12953056	0	PAR-3	111,116	JAM-2	54,59	PAR-3	JAM-2	56288	58494	Gene	Gene	associate|nmod|START_ENTITY associate|nsubj|members members|amod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
11489913	0	PAR-3	44,49	Junctional_adhesion_molecule	0,28	PAR-3	Junctional adhesion molecule	56288	50848	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Junctional_adhesion_molecule -LRB- JAM -RRB- binds to PAR-3 : a possible mechanism for the recruitment of PAR-3 to tight junctions .
11489913	0	PAR-3	95,100	Junctional_adhesion_molecule	0,28	PAR-3	Junctional adhesion molecule	56288	50848	Gene	Gene	tight|amod|START_ENTITY junctions|amod|tight recruitment|nmod|junctions mechanism|nmod|recruitment binds|dobj|mechanism binds|nsubj|END_ENTITY	Junctional_adhesion_molecule -LRB- JAM -RRB- binds to PAR-3 : a possible mechanism for the recruitment of PAR-3 to tight junctions .
12725730	0	PAR-3	75,80	PAR-6	43,48	PAR-3	PAR-6	56288	100506965	Gene	Gene	independently|nmod|START_ENTITY independently|amod|END_ENTITY	Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity .
19503097	0	PAR-3	41,46	PARD3	53,58	PAR-3	PARD3	56288	56288	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|appos|END_ENTITY	Defective expression of polarity protein PAR-3 gene -LRB- PARD3 -RRB- in esophageal_squamous_cell_carcinoma .
20122916	0	PAR-3	29,34	PKC-3	11,16	PAR-3	PKC-3	175783(Tax:6239)	173914(Tax:6239)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding to PKC-3 , but not to PAR-3 or to a conventional PDZ domain ligand , is required for PAR-6 function in C. _ elegans .
12953056	0	PAR-3	111,116	junctional_adhesion_molecule	4,32	PAR-3	junctional adhesion molecule	56288	50848	Gene	Gene	associate|nmod|START_ENTITY associate|nsubj|members members|amod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
10664248	0	PAR-4	30,35	PAR-1	24,29	PAR-4	PAR-1	9002	2149	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	The two-receptor system PAR-1 / PAR-4 mediates alpha-thrombin-induced -LSB- Ca -LRB- 2 + -RRB- -RSB- -LRB- i -RRB- mobilization in human astrocytoma cells .
26500666	0	PAR-4	28,33	Prostate_Apoptosis_Response_4	35,64	PAR-4	Prostate Apoptosis Response 4	5074	5074	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Plant-derived SAC domain of PAR-4 -LRB- Prostate_Apoptosis_Response_4 -RRB- exhibits growth inhibitory effects in prostate_cancer cells .
21186357	0	PAR-4	50,55	UNC-6	0,5	PAR-4	UNC-6	180185(Tax:6239)	180961(Tax:6239)	Gene	Gene	promote|nmod|START_ENTITY promote|nsubj|END_ENTITY	UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis_elegans neurons .
25176330	0	PAR-4	64,69	protease_activated_receptor_4	33,62	PAR-4	protease activated receptor 4	9002	9002	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Substituted indoles as selective protease_activated_receptor_4 -LRB- PAR-4 -RRB- antagonists : Discovery and SAR of ML354 .
11015310	0	PAR-4	153,158	thrombin	19,27	PAR-4	thrombin	116498(Tax:10116)	29251(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY mucosae|dep|role muscularis|dobj|mucosae muscularis|nsubj|modulation modulation|nmod|END_ENTITY	Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors -LRB- PARs -RRB- : a novel role for PAR-4 as opposed to PAR-1 .
24990321	0	PAR-4	50,55	thrombin	32,40	PAR-4	thrombin	347745	2147	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes .
12725730	0	PAR-6	43,48	PAR-3	75,80	PAR-6	PAR-3	100506965	56288	Gene	Gene	independently|amod|START_ENTITY independently|nmod|END_ENTITY	Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity .
26446588	0	PAR1	32,36	F2R	18,21	PAR1	F2R	2149	2149	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Evaluation of the F2R IVS-14A / T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention .
23647384	0	PAR1	29,33	Kallikrein_6	0,12	PAR1	Kallikrein 6	14062(Tax:10090)	19144(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Kallikrein_6 signals through PAR1 and PAR2 to promote neuron_injury and exacerbate glutamate neurotoxicity .
23687338	0	PAR1	34,38	MMP-1	6,11	PAR1	MMP-1	145624	4312	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination .
17376866	0	PAR1	47,51	Protease-activated_receptor-3	0,29	PAR1	Protease-activated receptor-3	2149	2151	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Protease-activated_receptor-3 -LRB- PAR3 -RRB- regulates PAR1 signaling by receptor dimerization .
16875721	0	PAR1	46,50	Protease_Activated_Receptor_1	15,44	PAR1	Protease Activated Receptor 1	2149	2149	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The pattern of Protease_Activated_Receptor_1 -LRB- PAR1 -RRB- expression in endometrial_carcinoma .
20412871	0	PAR1	36,40	SHOX	64,68	PAR1	SHOX	145624	6473	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Identification of the first de novo PAR1 deletion downstream of SHOX in an individual diagnosed with L __ ri-Weill_dyschondrosteosis -LRB- LWD -RRB- .
15572532	0	PAR1	60,64	Thrombin	0,8	PAR1	Thrombin	2149	2147	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon .
18353977	0	PAR1	75,79	Thrombin	0,8	PAR1	Thrombin	14062(Tax:10090)	14061(Tax:10090)	Gene	Gene	Galphaq|compound|START_ENTITY coupling|nmod|Galphaq production|nmod|coupling signaling|nsubj|production induces|dep|signaling induces|nsubj|END_ENTITY	Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho_kinase signaling pathways .
20442298	0	PAR1	94,98	Thrombin	0,8	PAR1	Thrombin	2149	2147	Gene	Gene	role|nmod|START_ENTITY signaling|nsubj|role regulates|parataxis|signaling regulates|nsubj|END_ENTITY	Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells : distinct role of PAR1 and PAR3 signaling .
12716374	0	PAR1	94,98	phospholipase_C-beta2	20,41	PAR1	phospholipase C-beta2	2149	5330	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Role of Galphaq and phospholipase_C-beta2 in human platelets activation by thrombin receptors PAR1 and PAR4 : studies in human platelets_deficient in Galphaq and phospholipase_C-beta2 .
24390664	0	PAR1	70,74	protease-activated_receptor-1	39,68	PAR1	protease-activated receptor-1	2149	2149	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Is there any diagnostic value of serum protease-activated_receptor-1 -LRB- PAR1 -RRB- levels on determination of epithelial_ovarian_carcinoma ?
22860064	0	PAR1	63,67	protease-activated_receptor_1	32,61	PAR1	protease-activated receptor 1	558477(Tax:7955)	558477(Tax:7955)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Developmental role of zebrafish protease-activated_receptor_1 -LRB- PAR1 -RRB- in the cardio-vascular_system .
10205017	0	PAR1	101,105	thrombin	38,46	PAR1	thrombin	25439(Tax:10116)	29251(Tax:10116)	Gene	Gene	proteinase-activated_receptor-1|appos|START_ENTITY role|nmod|proteinase-activated_receptor-1 actions|dep|role actions|nmod|END_ENTITY	Pro- and anti-inflammatory actions of thrombin : a distinct role for proteinase-activated_receptor-1 -LRB- PAR1 -RRB- .
11005807	0	PAR1	36,40	thrombin	41,49	PAR1	thrombin	2149	2147	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Substrate-assisted catalysis of the PAR1 thrombin receptor .
12563219	0	PAR1	23,27	thrombin	101,109	PAR1	thrombin	2149	2147	Gene	Gene	peptide|nmod|START_ENTITY stimulant|nsubj|peptide stimulant|advcl|END_ENTITY	The cleaved peptide of PAR1 is a more potent stimulant of platelet-endothelial cell adhesion than is thrombin .
15262827	0	PAR1	66,70	thrombin	47,55	PAR1	thrombin	2149	2147	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|receptor receptor|compound|END_ENTITY	Clinical inhibition of the seven-transmembrane thrombin receptor -LRB- PAR1 -RRB- by intravenous aprotinin during cardiothoracic surgery .
17595115	0	PAR1	29,33	thrombin	15,23	PAR1	thrombin	2149	2147	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site .
17595115	0	PAR1	29,33	thrombin	50,58	PAR1	thrombin	2149	2147	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|site site|compound|END_ENTITY	Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site .
18293826	0	PAR1	13,17	thrombin	4,12	PAR1	thrombin	2149	2147	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Why thrombin PAR1 receptors are important to the cardiac surgical patient .
20236938	0	PAR1	79,83	thrombin	21,29	PAR1	thrombin	2149	2147	Gene	Gene	fragment|nmod|START_ENTITY bound|nmod|fragment bound|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1 .
24964046	0	PAR2	24,28	Cathepsin_S	0,11	PAR2	Cathepsin S	2150	1520	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Cathepsin_S signals via PAR2 and generates a novel tethered ligand receptor agonist .
25118282	0	PAR2	59,63	Cathepsin_S	0,11	PAR2	Cathepsin S	14063(Tax:10090)	13040(Tax:10090)	Gene	Gene	agonism|nmod|START_ENTITY pain|nmod|agonism causes|dobj|pain causes|nsubj|END_ENTITY	Cathepsin_S causes inflammatory pain via biased agonism of PAR2 and TRPV4 .
26676790	0	PAR2	50,54	MMP-12	28,34	PAR2	MMP-12	2150	4321	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Pulmonary C Fibers Modulate MMP-12 Production via PAR2 and Are Involved in the Long-Term Airway Inflammation and Airway Hyperresponsiveness Induced by Respiratory_Syncytial_Virus Infection .
12479889	0	PAR2	31,35	Protease-activated_receptor_2	0,29	PAR2	Protease-activated receptor 2	2150	2150	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Protease-activated_receptor_2 -LRB- PAR2 -RRB- mediates vascular smooth muscle cell migration induced by tissue factor/factor VIIa complex .
23288842	0	PAR2	31,35	Protease-activated_receptor_2	0,29	PAR2	Protease-activated receptor 2	2150	2150	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Protease-activated_receptor_2 -LRB- PAR2 -RRB- protein and transient_receptor_potential_vanilloid_4 -LRB- TRPV4 -RRB- protein coupling is required for sustained inflammatory signaling .
25734998	0	PAR2	31,35	Protease_activated_receptor_2	0,29	PAR2	Protease activated receptor 2	14063(Tax:10090)	14063(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Protease_activated_receptor_2 -LRB- PAR2 -RRB- activation is sufficient to induce the transition to a chronic_pain state .
20972877	0	PAR2	10,14	TNF-a	29,34	PAR2	TNF-a	14063(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Effect of PAR2 in regulating TNF-a and NAD -LRB- P -RRB- H oxidase in coronary arterioles in type 2 diabetic mice .
15765104	0	PAR2	117,121	protease-activated_receptor-2	27,56	PAR2	protease-activated receptor-2	2150	2150	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of a highly potent protease-activated_receptor-2 -LRB- PAR2 -RRB- activating peptide , -LSB- 3H -RSB- 2-furoyl-LIGRL-NH2 , to human PAR2 .
21072196	0	PAR2	68,72	protease-activated_receptor_2	37,66	PAR2	protease-activated receptor 2	2150	2150	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Profiling gene expression induced by protease-activated_receptor_2 -LRB- PAR2 -RRB- activation in human kidney cells .
26631441	0	PAR2	95,99	protease-activated_receptor_2	64,93	PAR2	protease-activated receptor 2	14063(Tax:10090)	14063(Tax:10090)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated_receptor_2 -LRB- PAR2 -RRB- antagonists .
21546388	0	PAR2	48,52	proteinase-activated_receptor_2	15,46	PAR2	proteinase-activated receptor 2	2150	2150	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TGF-b1 induces proteinase-activated_receptor_2 -LRB- PAR2 -RRB- expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6 .
22411985	0	PAR2	48,52	proteinase-activated_receptor_2	15,46	PAR2	proteinase-activated receptor 2	2150	2150	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Novel role for proteinase-activated_receptor_2 -LRB- PAR2 -RRB- in membrane trafficking of proteinase-activated_receptor_4 -LRB- PAR4 -RRB- .
12459187	0	PAR3	57,61	PAR3beta	0,8	PAR3	PAR3beta	56288	117583	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	PAR3beta , a novel homologue of the cell polarity protein PAR3 , localizes to tight junctions .
10766244	0	PAR3	0,4	PAR4	23,27	PAR3	PAR4	112235(Tax:10090)	14065(Tax:10090)	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	PAR3 is a cofactor for PAR4 activation by thrombin .
12459187	0	PAR3beta	0,8	PAR3	57,61	PAR3beta	PAR3	117583	56288	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	PAR3beta , a novel homologue of the cell polarity protein PAR3 , localizes to tight junctions .
24723492	0	PAR4	52,56	P2Y12	32,37	PAR4	P2Y12	9002	64805	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated Akt activation .
10766244	0	PAR4	23,27	PAR3	0,4	PAR4	PAR3	14065(Tax:10090)	112235(Tax:10090)	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	PAR3 is a cofactor for PAR4 activation by thrombin .
19889854	0	PAR4	33,37	Proteinase-activated_receptor-4	0,31	PAR4	Proteinase-activated receptor-4	116498(Tax:10116)	116498(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Proteinase-activated_receptor-4 -LRB- PAR4 -RRB- activation leads to sensitization of rat joint primary afferents via a bradykinin_B2 receptor-dependent mechanism .
10049593	0	PARC	10,14	SCYA18	21,27	PARC	SCYA18	6362	6362	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chemokine PARC gene -LRB- SCYA18 -RRB- generated by fusion of two MIP-1alpha / LD78alpha-like genes .
19503097	0	PARD3	53,58	PAR-3	41,46	PARD3	PAR-3	56288	56288	Gene	Gene	expression|appos|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	Defective expression of polarity protein PAR-3 gene -LRB- PARD3 -RRB- in esophageal_squamous_cell_carcinoma .
25833829	0	PARD3	0,5	STAT3	60,65	PARD3	STAT3	56288	6774	Gene	Gene	Inactivation|compound|START_ENTITY Inactivation|nmod|END_ENTITY	PARD3 Inactivation in Lung Squamous_Cell_Carcinomas Impairs STAT3 and Promotes Malignant Invasion .
26116754	0	PARD3	0,5	TAZ	14,17	PARD3	TAZ	56288	6901	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction .
21376232	0	PARIS	0,5	PGC-1a	29,35	PARIS	PGC-1a	155061	10891	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	PARIS -LRB- ZNF746 -RRB- repression of PGC-1a contributes to neurodegeneration in Parkinson 's _ disease .
18358451	0	PARK11	45,51	GIGYF2	17,23	PARK11	GIGYF2	26058	26058	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Mutations in the GIGYF2 -LRB- TNRC15 -RRB- gene at the PARK11 locus in familial_Parkinson_disease .
18358451	0	PARK11	45,51	TNRC15	25,31	PARK11	TNRC15	26058	26058	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Mutations in the GIGYF2 -LRB- TNRC15 -RRB- gene at the PARK11 locus in familial_Parkinson_disease .
21782285	0	PARK3	42,47	sepiapterin_reductase	8,29	PARK3	sepiapterin reductase	5072	6697	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Role of sepiapterin_reductase gene at the PARK3 locus in Parkinson 's _ disease .
14662519	0	PARK7	24,29	DJ-1	18,22	PARK7	DJ-1	11315	11315	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of DJ-1 -LRB- PARK7 -RRB- in normal human CNS and idiopathic_Parkinson 's _ disease .
14872018	0	PARK7	6,11	DJ-1	0,4	PARK7	DJ-1	11315	11315	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	DJ-1 -LRB- PARK7 -RRB- mutations are less frequent than Parkin -LRB- PARK2 -RRB- mutations in early-onset Parkinson_disease .
15955416	0	PARK7	91,96	DJ-1	85,89	PARK7	DJ-1	11315	11315	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Development , characterisation and epitope mapping of novel monoclonal antibodies for DJ-1 -LRB- PARK7 -RRB- protein .
23530187	0	PARK7	35,40	DJ-1	30,34	PARK7	DJ-1	57320(Tax:10090)	57320(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY END_ENTITY|parataxis|protects	Parkinson-susceptibility gene DJ-1 / PARK7 protects the murine heart from oxidative damage in vivo .
26634899	0	PARK7	28,33	DJ-1	23,27	PARK7	DJ-1	11315	11315	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Differential effect of DJ-1 / PARK7 on development of natural and induced regulatory T cells .
26965687	0	PARK7	58,63	DJ-1	65,69	PARK7	DJ-1	11315	11315	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	The effects of variants in the PARK2 -LRB- parkin -RRB- , PINK1 , and PARK7 -LRB- DJ-1 -RRB- genes along with evidence for their pathogenicity .
17804834	0	PARK8	82,87	LRRK2	0,5	PARK8	LRRK2	120892	120892	Gene	Gene	mutation|nmod|START_ENTITY mutation|nsubj|END_ENTITY	LRRK2 mutation analysis in Parkinson_disease families with evidence of linkage to PARK8 .
20310007	0	PARK9	19,24	ATP13A2	0,7	PARK9	ATP13A2	23400	23400	Gene	Gene	mutations|appos|START_ENTITY mutations|nummod|END_ENTITY	ATP13A2 mutations -LRB- PARK9 -RRB- cause neurodegeneration_with_brain_iron_accumulation .
22288903	0	PARK9	31,36	ATP13A2	22,29	PARK9	ATP13A2	23400	23400	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hypoxia regulation of ATP13A2 -LRB- PARK9 -RRB- gene transcription .
26421390	0	PARK9	79,84	ATP13A2	70,77	PARK9	ATP13A2	23400	23400	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Juvenile_dystonia-parkinsonism syndrome caused by a novel p.S941Tfs1X ATP13A2 -LRB- PARK9 -RRB- mutation .
21138942	0	PARL	62,66	PINK1	0,5	PARL	PINK1	55486	65018	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|nsubj|END_ENTITY	PINK1 cleavage at position A103 by the mitochondrial protease PARL .
17459151	0	PARP	110,114	ATM	20,23	PARP	ATM	142	472	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition .
17459151	0	PARP	110,114	ATM	82,85	PARP	ATM	142	472	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|cells cells|compound|END_ENTITY	Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition .
19717351	0	PARP	0,4	ATM	112,115	PARP	ATM	1302	472	Gene	Gene	inhibition|compound|START_ENTITY signals|nsubj|inhibition signals|dobj|response response|acl|mediated mediated|nmod|END_ENTITY	PARP inhibition during alkylation-induced genotoxic_stress signals a cell cycle checkpoint response mediated by ATM .
22416035	0	PARP	25,29	ATM	94,97	PARP	ATM	142	472	Gene	Gene	cytotoxicity|nmod|START_ENTITY inhibition|nsubj|cytotoxicity inhibition|nmod|mutations mutations|nmod|END_ENTITY	Enhanced cytotoxicity of PARP inhibition in mantle_cell_lymphoma harbouring mutations in both ATM and p53 .
16309216	0	PARP	38,42	Caspase-3	0,9	PARP	Caspase-3	142	836	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Caspase-3 activation and induction of PARP cleavage by cyclic_dipeptide cyclo -LRB- Phe-Pro -RRB- in HT-29 cells .
20049735	0	PARP	53,57	PTEN	30,34	PARP	PTEN	142	5728	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors .
20944090	0	PARP	84,88	PTEN	0,4	PARP	PTEN	142	5728	Gene	Gene	inhibitors|compound|START_ENTITY predicts|nmod|inhibitors predicts|nsubj|deficiency_in_endometrioid_endometrial_adenocarcinomas deficiency_in_endometrioid_endometrial_adenocarcinomas|compound|END_ENTITY	PTEN deficiency_in_endometrioid_endometrial_adenocarcinomas predicts sensitivity to PARP inhibitors .
16405863	0	PARP	190,194	caspase-3	139,148	PARP	caspase-3	142	836	Gene	Gene	polymerase|appos|START_ENTITY polymerase|amod|END_ENTITY	Detection of cleaved alpha-fodrin autoantigen in Sj gren 's _ syndrome : apoptosis and co-localisation of cleaved alpha-fodrin with activated caspase-3 and cleaved poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- in labial salivary glands .
17404069	0	PARP	80,84	caspase-3	54,63	PARP	caspase-3	142	836	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Resveratrol inhibits IL-1_beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro .
19029405	0	PARP	98,102	caspase-3	58,67	PARP	caspase-3	142	836	Gene	Gene	START_ENTITY|nsubj|Assessment Assessment|nmod|apoptosis apoptosis|acl|immunohistochemistry immunohistochemistry|advcl|END_ENTITY	Assessment of apoptosis by immunohistochemistry to active caspase-3 , active caspase-7 , or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma .
23161104	0	PARP	45,49	caspase-3	35,44	PARP	caspase-3	142	836	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|glucose glucose|acl|induced induced|dobj|/ /|amod|END_ENTITY	High levels of glucose induced the caspase-3 / PARP signaling pathway , leading to apoptosis in human periodontal ligament fibroblasts .
24728469	0	PARP	65,69	caspase-3	55,64	PARP	caspase-3	142	836	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Zebularine induces prolonged apoptosis effects via the caspase-3 / PARP pathway in head_and_neck_cancer cells .
20673794	0	PARP	86,90	caspase-9	75,84	PARP	caspase-9	1302	842	Gene	Gene	release|dep|START_ENTITY release|amod|END_ENTITY	Typhonium_flagelliforme induces apoptosis in CEMss cells via activation of caspase-9 , PARP cleavage and cytochrome_c release : its activation coupled with G0/G1 phase cell cycle arrest .
26546619	0	PARP	76,80	mTOR	0,4	PARP	mTOR	1302	21977(Tax:10090)	Gene	Gene	Inhibitors|compound|START_ENTITY END_ENTITY|nmod|Inhibitors	mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast_Cancer .
27026705	0	PARP-1	0,6	ABCA1	30,35	PARP-1	ABCA1	11545(Tax:10090)	11303(Tax:10090)	Gene	Gene	Represses|nsubj|START_ENTITY Represses|dobj|Expression Expression|compound|END_ENTITY	PARP-1 Represses LXR-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages .
23382195	0	PARP-1	52,58	AMPKa2	0,6	PARP-1	AMPKa2	142	5563	Gene	Gene	exerts|nmod|START_ENTITY exerts|nsubj|END_ENTITY	AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6 .
20693103	0	PARP-1	100,106	AT2_receptor	50,62	PARP-1	AT2 receptor	11545(Tax:10090)	11609(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|downregulation downregulation|nmod|END_ENTITY	Ethanol-induced downregulation of the angiotensin AT2_receptor in murine fibroblasts is mediated by PARP-1 .
11238919	0	PARP-1	29,35	Atm	36,39	PARP-1	Atm	11545(Tax:10090)	11920(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development .
18539602	0	PARP-1	31,37	CCCTC-binding_factor	0,20	PARP-1	CCCTC-binding factor	11545(Tax:10090)	13018(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	CCCTC-binding_factor activates PARP-1 affecting DNA methylation machinery .
26619102	0	PARP-1	0,6	CD34	21,25	PARP-1	CD34	142	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|+ +|compound|END_ENTITY	PARP-1 expression in CD34 + leukemic cells in childhood acute_lymphoblastic_leukemia : relation to response to initial therapy and other prognostic factors .
26181065	0	PARP-1	83,89	Cytidine_Deaminase	44,62	PARP-1	Cytidine Deaminase	142	978	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Pyrimidine Pool Disequilibrium Induced by a Cytidine_Deaminase Deficiency Inhibits PARP-1 Activity , Leading to the Under Replication of DNA .
18773488	0	PARP-1	63,69	E-cadherin	33,43	PARP-1	E-cadherin	142	999	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Integrin-linked_kinase regulates E-cadherin expression through PARP-1 .
17950909	0	PARP-1	0,6	ERK	25,28	PARP-1	ERK	142	5594	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	PARP-1 activation in the ERK signaling pathway .
17244536	0	PARP-1	16,22	ERK2	52,56	PARP-1	ERK2	142	5594	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity : a link to histone acetylation .
23977081	0	PARP-1	0,6	Foxp3	82,87	PARP-1	Foxp3	11545(Tax:10090)	20371(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3 .
22844406	0	PARP-1	20,26	HOXB7	38,43	PARP-1	HOXB7	142	3217	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity .
18773488	0	PARP-1	63,69	Integrin-linked_kinase	0,22	PARP-1	Integrin-linked kinase	142	3611	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Integrin-linked_kinase regulates E-cadherin expression through PARP-1 .
20920579	0	PARP-1	128,134	MKP-1	14,19	PARP-1	MKP-1	142	1843	Gene	Gene	activation|compound|START_ENTITY effect|nmod|activation mechanism|nmod|effect Regulation|dep|mechanism Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress : a new mechanism for the cytoplasmic effect of PARP-1 activation .
20920579	0	PARP-1	54,60	MKP-1	14,19	PARP-1	MKP-1	142	1843	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress : a new mechanism for the cytoplasmic effect of PARP-1 activation .
20434371	0	PARP-1	18,24	MMP-9	28,33	PARP-1	MMP-9	11545(Tax:10090)	17395(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated_cardiomyopathy .
18660545	0	PARP-1	0,6	Ptc1	23,27	PARP-1	Ptc1	11545(Tax:10090)	19206(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	PARP-1 cooperates with Ptc1 to suppress medulloblastoma_and_basal_cell_carcinoma .
26344098	0	PARP-1	24,30	Timeless	0,8	PARP-1	Timeless	142	8914	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair .
12358742	0	PARP-1	58,64	p53	51,54	PARP-1	p53	142	7157	Gene	Gene	novel|nmod|START_ENTITY novel|nmod|modification modification|nmod|END_ENTITY	A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism .
20067769	0	PARP-1	121,127	p53	171,174	PARP-1	p53	142	7157	Gene	Gene	results|compound|START_ENTITY topoisomerase|nmod|results topoisomerase|nmod|re-activation re-activation|nmod|pathway pathway|compound|END_ENTITY	Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints .
22395446	0	PARP-1	107,113	p53	114,117	PARP-1	p53	11545(Tax:10090)	22060(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular_carcinoma apoptosis via PARP-1 / p53 pathway .
24323920	1	PARP-1	57,63	p53	43,46	PARP-1	p53	142	7157	Gene	Gene	dependent|amod|START_ENTITY necrosis|amod|dependent regulates|dobj|necrosis regulates|nsubj|END_ENTITY	Let me count the ways : p53 regulates PARP-1 dependent necrosis .
25182801	0	PARP-1	73,79	p53	10,13	PARP-1	p53	142	7157	Gene	Gene	cells|nmod|START_ENTITY sensitivity|nmod|cells activity|nmod|sensitivity activity|compound|END_ENTITY	Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase i inhibitor or radiation .
24757201	0	PARP-2	22,28	MicroRNA-149	0,12	PARP-2	MicroRNA-149	11546(Tax:10090)	387167(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1 / PGC-1a network in skeletal muscle .
21459329	0	PARP-2	0,6	SIRT1	17,22	PARP-2	SIRT1	11546(Tax:10090)	93759(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	PARP-2 regulates SIRT1 expression and whole-body energy expenditure .
16461352	0	PARP-2	0,6	TTF-1	22,27	PARP-2	TTF-1	11546(Tax:10090)	22130(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B .
23095674	0	PARP1	79,84	CDK2	60,64	PARP1	CDK2	142	1017	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	PARty promoters : hormone-dependent gene regulation requires CDK2 activation of PARP1 .
26370511	0	PARP1	43,48	EZH2	83,87	PARP1	EZH2	142	2146	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Global transcriptome analysis reveals that PARP1 regulates gene expression through EZH2 .
23851505	0	PARP1	22,27	GATA3	0,5	PARP1	GATA3	142	2625	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	GATA3 cooperates with PARP1 to regulate CCND1 transcription through modulating histone H1 incorporation .
25607726	0	PARP1	91,96	JMJD2B	124,130	PARP1	JMJD2B	142	23030	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Emodin attenuates radioresistance induced by hypoxia in HepG2 cells via the enhancement of PARP1 cleavage and inhibition of JMJD2B .
23219533	0	PARP1	0,5	PAP	16,19	PARP1	PAP	142	10914	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	PARP1 represses PAP and inhibits polyadenylation during heat_shock .
21680843	0	PARP1	53,58	SIRT6	0,5	PARP1	SIRT6	142	51548	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	SIRT6 promotes DNA repair under stress by activating PARP1 .
25400754	0	PARP1	72,77	SOD2	66,70	PARP1	SOD2	142	6648	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Clinical significance of NQO1 polymorphism and expression of p53 , SOD2 , PARP1 in limited-stage_small_cell_lung_cancer .
26391948	0	PARP1	38,43	WRN	79,82	PARP1	WRN	142	7486	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential and concordant roles for PARP1 and poly -LRB- ADP-ribose -RRB- in regulating WRN and RECQL5 activities .
23449221	0	PARP3	4,9	APLF	48,52	PARP3	APLF	10039	200558	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|break break|compound|END_ENTITY	The PARP3 - and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair .
26040766	0	PARP3	0,5	FoxM1	21,26	PARP3	FoxM1	235587(Tax:10090)	14235(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PARP3 interacts with FoxM1 to confer glioblastoma cell radioresistance .
12499396	0	PARVB	52,57	alphaPIX	15,23	PARVB	alphaPIX	29780	9459	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of alphaPIX -LRB- ARHGEF6 -RRB- with beta-parvin -LRB- PARVB -RRB- suggests an involvement of alphaPIX in integrin-mediated signaling .
26892021	0	PASD1	0,5	STAT3	15,20	PASD1	STAT3	382221(Tax:10090)	20848(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activity activity|compound|END_ENTITY	PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus .
1688389	1	PASP	101,105	pancreas-specific_protein	74,99	PASP	pancreas-specific protein	1360	1360	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of pancreas-specific_protein -LRB- PASP -RRB- in acute_pancreatitis and other abdominal_diseases .
1699598	0	PAS_IV	0,6	CD36	110,114	PAS IV	CD36	948	948	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	PAS_IV , an integral membrane protein of mammary epithelial cells , is related to platelet and endothelial cell CD36 -LRB- GP_IV -RRB- .
22615577	0	PAT-2	11,16	CDC-42	17,23	PAT-2	CDC-42	176240(Tax:6239)	174233(Tax:6239)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|signaling signaling|compound|END_ENTITY	Integrin a PAT-2 / CDC-42 signaling is required for muscle-mediated clearance of apoptotic cells in Caenorhabditis_elegans .
24632947	0	PAT-2	76,81	CDC-42	13,19	PAT-2	CDC-42	176240(Tax:6239)	174233(Tax:6239)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Small GTPase CDC-42 promotes apoptotic cell corpse clearance in response to PAT-2 and CED-1 in C. _ elegans .
20630947	0	PAT1	11,15	Kinesin-1	32,41	PAT1	Kinesin-1	31593(Tax:7227)	36810(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motility .
14600155	0	PAT1	124,128	PAT2	36,40	PAT1	PAT2	206358	153201	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	The proton/amino _ acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1 .
15203903	0	PAT1	35,39	SLC26A6	41,48	PAT1	SLC26A6	206358	65010	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of anion exchange transporter PAT1 -LRB- SLC26A6 -RRB- in intestinal absorption of organic anions .
9077451	0	PAT1	0,4	acetyltransferase	34,51	PAT1	acetyltransferase	850440(Tax:4932)	853237(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	PAT1 , an evolutionarily conserved acetyltransferase homologue , is required for multiple steps in the cell cycle .
14600155	0	PAT2	36,40	PAT1	124,128	PAT2	PAT1	153201	206358	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	The proton/amino _ acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1 .
22052190	0	PATZ1	54,59	p53	108,111	PATZ1	p53	23598	7157	Gene	Gene	and_AT-hook-containing_zinc_finger_protein_1|appos|START_ENTITY inhibits|nsubj|and_AT-hook-containing_zinc_finger_protein_1 inhibits|nmod|END_ENTITY	POZ/BTB _ and_AT-hook-containing_zinc_finger_protein_1 -LRB- PATZ1 -RRB- inhibits endothelial cell senescence through a p53 dependent pathway .
24336083	0	PATZ1	0,5	p53	21,24	PATZ1	p53	56218(Tax:10090)	22060(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context .
25755280	0	PATZ1	0,5	p53	68,71	PATZ1	p53	23598	7157	Gene	Gene	factor|nsubj|START_ENTITY factor|acl:relcl|inhibits inhibits|dobj|function function|compound|END_ENTITY	PATZ1 is a DNA damage responsive transcription factor that inhibits p53 function .
20735158	0	PAWR	44,48	Par-4	37,42	PAWR	Par-4	5074	5074	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence of involvement of the human Par-4 -LRB- PAWR -RRB- gene in major_depressive_disorder .
7527372	0	PAX-6	27,32	WAGR	2,6	PAX-6	WAGR	5080	5080	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	A WAGR region gene between PAX-6 and FSHB expressed in fetal brain .
21876729	0	PAX2	0,4	ADAM10	15,21	PAX2	ADAM10	5076	102	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells .
21880579	0	PAX2	25,29	ADAM10	40,46	PAX2	ADAM10	5076	102	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	The transcription factor PAX2 regulates ADAM10 expression in renal_cell_carcinoma .
19517575	0	PAX2	28,32	Angiotensin_II	0,14	PAX2	Angiotensin II	5076	183	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Angiotensin_II up-regulates PAX2 oncogene expression and activity in prostate_cancer via the angiotensin_II type I receptor .
16368682	0	PAX2	0,4	WNT4	15,19	PAX2	WNT4	5076	54361	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	PAX2 activates WNT4 expression during mammalian kidney development .
19048125	0	PAX2	22,26	WNT5A	0,5	PAX2	WNT5A	5076	7474	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms_tumorigenesis .
26252164	0	PAX3	15,19	FOXD3	0,5	PAX3	FOXD3	5077	27022	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FOXD3 Promotes PAX3 Expression in Melanoma Cells .
26252164	0	PAX3	15,19	FOXD3	0,5	PAX3	FOXD3	5077	27022	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	FOXD3 Promotes PAX3 Expression in Melanoma Cells .
24371814	0	PAX3	45,49	PAX7	51,55	PAX3	PAX7	5077	5081	Gene	Gene	muscle|compound|START_ENTITY muscle|compound|END_ENTITY	Derivation and FACS-mediated purification of PAX3 + / PAX7 + skeletal muscle precursors from human pluripotent stem cells .
23020925	0	PAX3	32,36	TBX2	0,4	PAX3	TBX2	5077	6909	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	TBX2 expression is regulated by PAX3 in the melanocyte lineage .
19081068	0	PAX3	17,21	TGF-beta	0,8	PAX3	TGF-beta	5077	7040	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	TGF-beta targets PAX3 to control melanocyte differentiation .
24570025	0	PAX3	44,48	paired_box_3	30,42	PAX3	paired box 3	540951(Tax:9913)	540951(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	SNP and haplotype analysis of paired_box_3 -LRB- PAX3 -RRB- gene provide evidence for association with growth traits in Chinese cattle .
22593617	0	PAX5	82,86	BLIMP1	67,73	PAX5	BLIMP1	5079	639	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	B cell receptor-ERK1 / 2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation : a mechanism of antigen-triggering plasma cell differentiation .
16891199	0	PAX5	48,52	B_cell-specific_activator_protein	14,47	PAX5	B cell-specific activator protein	5079	5079	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of B_cell-specific_activator_protein / PAX5 in acute_myeloid_leukemia with t -LRB- 8 ; 21 -RRB- -LRB- q22 ; q22 -RRB- .
22449230	0	PAX5	97,101	CD30	18,22	PAX5	CD30	5079	943	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Primary cutaneous CD30 positive T-cell lymphoproliferative_disorders with aberrant expression of PAX5 : report of three cases .
25403488	0	PAX5	79,83	MICAL3	69,75	PAX5	MICAL3	5079	57553	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	miR-648 targets ET-1 mRNA and is co-transcriptionally regulated with MICAL3 by PAX5 .
23321250	0	PAX5	16,20	SOX11	0,5	PAX5	SOX11	18507(Tax:10090)	20666(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive_mantle_cell_lymphoma .
25277182	0	PAX5	59,63	paired_box_5	45,57	PAX5	paired box 5	5079	5079	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Applicability of the methylated_CpG sites of paired_box_5 -LRB- PAX5 -RRB- promoter for prediction the prognosis of gastric_cancer .
22583899	0	PAX6	32,36	FABP7	18,23	PAX6	FABP7	5080	2173	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the FABP7 gene by PAX6 in malignant_glioma cells .
26021864	0	PAX6	0,4	Nfia	23,27	PAX6	Nfia	18508(Tax:10090)	18027(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	PAX6 does not regulate Nfia and Nfib expression during neocortical development .
26021864	0	PAX6	0,4	Nfia	23,27	PAX6	Nfia	18508(Tax:10090)	18027(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	PAX6 does not regulate Nfia and Nfib expression during neocortical development .
24737483	0	PAX6	0,4	miR-335	24,31	PAX6	miR-335	5080	442904	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	PAX6 , a novel target of miR-335 , inhibits cell proliferation and invasion in glioma cells .
24047795	0	PAX6	7,11	prohormone_convertase_2	26,49	PAX6	prohormone convertase 2	18508(Tax:10090)	18549(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Mutant PAX6 downregulates prohormone_convertase_2 expression in mouse islets .
19618119	0	PAX6	0,4	vascular_endothelial_growth_factor_A	62,98	PAX6	vascular endothelial growth factor A	5080	7422	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	PAX6 suppression of glioma angiogenesis and the expression of vascular_endothelial_growth_factor_A .
26304770	0	PAX7	16,20	NEDD4	0,5	PAX7	NEDD4	5081	4734	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	NEDD4 Regulates PAX7 Levels Promoting Activation of the Differentiation Program in Skeletal Muscle Precursors .
24371814	0	PAX7	51,55	PAX3	45,49	PAX7	PAX3	5081	5077	Gene	Gene	muscle|compound|START_ENTITY muscle|compound|END_ENTITY	Derivation and FACS-mediated purification of PAX3 + / PAX7 + skeletal muscle precursors from human pluripotent stem cells .
24251689	0	PAX7	41,45	paired_box_7	27,39	PAX7	paired box 7	395942(Tax:9031)	395942(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel 31-bp indel in the paired_box_7 -LRB- PAX7 -RRB- gene is associated with chicken performance traits .
21602887	0	PAX8	0,4	E2F1	64,68	PAX8	E2F1	7849	1869	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein .
26030152	0	PAX8	45,49	Neuropilin-2	0,12	PAX8	Neuropilin-2	81819(Tax:10116)	81527(Tax:10116)	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells .
22644304	0	PAX8	10,14	Pair-Box	0,8	PAX8	Pair-Box	7849	7849	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pair-Box -LRB- PAX8 -RRB- protein-positive expression is associated with poor disease outcome in women with endometrial_cancer .
20572292	0	PAX8	30,34	paired_box_gene_8	11,28	PAX8	paired box gene 8	7849	7849	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Utility of paired_box_gene_8 -LRB- PAX8 -RRB- expression in fluid and fine-needle aspiration cytology : an immunohistochemical study of metastatic ovarian_serous_carcinoma .
24462208	0	PAXT-1	0,6	XRN2	16,20	PAXT-1	XRN2	187613(Tax:6239)	22803	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activity activity|compound|END_ENTITY	PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain .
9388203	0	PAX_8	0,5	WT1	22,25	PAX 8	WT1	7849	7490	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	PAX_8 regulates human WT1 transcription through a novel DNA binding site .
12912994	0	PB1	54,57	MEK5	49,53	PB1	MEK5	26952	5607	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway .
7533029	0	PBDX	0,4	XG_blood_group	12,26	PBDX	XG blood group	7499	7499	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	PBDX is the XG_blood_group gene .
22487217	0	PBEF	61,65	pre-B-cell_colony-enhancing_factor	25,59	PBEF	pre-B-cell colony-enhancing factor	10135	10135	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Pleiotropic functions of pre-B-cell_colony-enhancing_factor -LRB- PBEF -RRB- revealed by transcriptomics of human pulmonary microvascular endothelial cells treated with PBEFsiRNA .
16636125	0	PBEF1	40,45	visfatin	25,33	PBEF1	visfatin	10135	10135	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variation in the visfatin gene -LRB- PBEF1 -RRB- and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans .
25408419	0	PBF	19,22	p53	29,32	PBF	p53	754	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal_cancer .
2542327	0	PBG-D	125,130	porphobilinogen_deaminase	98,123	PBG-D	porphobilinogen deaminase	3145	3145	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulated expression of the overlapping ubiquitous and erythroid transcription units of the human porphobilinogen_deaminase -LRB- PBG-D -RRB- gene introduced into non-erythroid and erythroid cells .
16171862	0	PBK	34,37	PDZ-binding_kinase	14,32	PBK	PDZ-binding kinase	55872	55872	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of PDZ-binding_kinase -LRB- PBK -RRB- is regulated by cell cycle-specific transcription factors E2F and CREB/ATF .
6187715	0	PBP	57,60	Prostatic_Binding_Protein	30,55	PBP	Prostatic Binding Protein	29542(Tax:10116)	29542(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Intracellular localization of Prostatic_Binding_Protein -LRB- PBP -RRB- in rat prostate by light and electron microscopic immunocytochemistry .
9708794	0	PBP	169,172	peroxisome_proliferator-activated_receptor_gamma	31,79	PBP	peroxisome proliferator-activated receptor gamma	19014(Tax:10090)	19016(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Differential expression of the peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- and its coactivators steroid_receptor_coactivator-1 and PPAR-binding_protein PBP in the brown fat , urinary_bladder , colon , and breast of the mouse .
8738137	0	PBP	86,89	phosphatidylethanolamine_binding_protein	44,84	PBP	phosphatidylethanolamine binding protein	5037	5037	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Sequence analysis and immunolocalisation of phosphatidylethanolamine_binding_protein -LRB- PBP -RRB- in human brain tissue .
10965884	0	PBR	105,108	peripheral-type_benzodiazepine_receptor	64,103	PBR	peripheral-type benzodiazepine receptor	24230(Tax:10116)	24230(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The peroxisome proliferator perfluorodecanoic_acid inhibits the peripheral-type_benzodiazepine_receptor -LRB- PBR -RRB- expression and hormone-stimulated mitochondrial cholesterol transport and steroid formation in Leydig cells .
1332905	0	PBR	74,77	peripheral-type_benzodiazepine_receptor	33,72	PBR	peripheral-type benzodiazepine receptor	12257(Tax:10090)	12257(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cell surface localization of the peripheral-type_benzodiazepine_receptor -LRB- PBR -RRB- in adrenal cortex .
15769477	0	PBR	71,74	peripheral_benzodiazepine_receptor	35,69	PBR	peripheral benzodiazepine receptor	706	706	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Nuclear location-dependent role of peripheral_benzodiazepine_receptor -LRB- PBR -RRB- in hepatic_tumoral cell lines proliferation .
16511838	0	PBR	67,70	peripheral_benzodiazepine_receptor	31,65	PBR	peripheral benzodiazepine receptor	706	706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence that variation in the peripheral_benzodiazepine_receptor -LRB- PBR -RRB- gene influences susceptibility to panic_disorder .
24166983	0	PBRM1	41,46	BAP1	48,52	PBRM1	BAP1	55193	8314	Gene	Gene	KDM6A|appos|START_ENTITY KDM6A|appos|END_ENTITY	Clinical and pathological impact of VHL , PBRM1 , BAP1 , SETD2 , KDM6A , and JARID1c in clear_cell_renal_cell_carcinoma .
26300218	6	PBRM1	945,950	BAP1	952,956	PBRM1	BAP1	55193	8314	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	RESULTS : PBRM1 and BAP1 expression was PBRM1 + BAP1 + in 40.1 % of tumors , PBRM1 - BAP1 + in 48.6 % , PBRM1 + BAP1 - in 8.7 % and PBRM1 - BAP1 - in 1.8 % .
24166983	0	PBRM1	41,46	SETD2	54,59	PBRM1	SETD2	55193	29072	Gene	Gene	KDM6A|appos|START_ENTITY KDM6A|appos|END_ENTITY	Clinical and pathological impact of VHL , PBRM1 , BAP1 , SETD2 , KDM6A , and JARID1c in clear_cell_renal_cell_carcinoma .
11795258	0	PBSF	24,28	SDF-1	18,23	PBSF	SDF-1	6387	6387	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of chemokine SDF-1 / PBSF and its receptor CXCR4 in blood vessel development .
23264595	0	PBX3	0,4	HOXA9	33,38	PBX3	HOXA9	5090	3205	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	PBX3 is an important cofactor of HOXA9 in leukemogenesis .
7698008	0	PC	51,53	pyruvate_carboxylase	24,44	PC	pyruvate carboxylase	5091	5091	Gene	Gene	Assignment|appos|START_ENTITY Assignment|nmod|gene gene|compound|END_ENTITY	Assignment of the human pyruvate_carboxylase gene -LRB- PC -RRB- to 11q13 .4 by fluorescence in situ hybridisation .
26011939	0	PC-1	0,4	PrLZ	5,9	PC-1	PrLZ	7163	7163	Gene	Gene	START_ENTITY|appos|confers confers|nsubj|END_ENTITY	PC-1 / PrLZ confers resistance to rapamycin in prostate_cancer cells through increased 4E-BP1 stability .
12715715	0	PC-1	11,15	TNF-alpha	1,10	PC-1	TNF-alpha	5310	7124	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	-LSB- TNF-alpha PC-1 gene polymorphisms and pre-diabetes quantitative features in the Polish population -RSB- .
20423888	0	PC-1	1,5	c-myc	15,20	PC-1	c-myc	7163	4609	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	-LSB- PC-1 enhances c-myc gene expression in prostate_cancer cells -RSB- .
10615944	0	PC-1	22,26	insulin_receptor	41,57	PC-1	insulin receptor	5167	3643	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|function function|compound|END_ENTITY	Membrane glycoprotein PC-1 inhibition of insulin_receptor function occurs via direct interaction with the receptor alpha-subunit .
11289049	0	PC-1	55,59	insulin_receptor	79,95	PC-1	insulin receptor	5122	3643	Gene	Gene	variant|nmod|START_ENTITY interacts|nsubj|variant interacts|nmod|insulin insulin|compound|END_ENTITY	The Q allele variant -LRB- GLN121 -RRB- of membrane glycoprotein PC-1 interacts with the insulin_receptor and inhibits insulin signaling more effectively than the common K allele variant -LRB- LYS121 -RRB- .
15677494	0	PC-1	60,64	insulin_receptor	32,48	PC-1	insulin receptor	5167	3643	Gene	Gene	NPP1|compound|START_ENTITY inhibitor|appos|NPP1 inhibitor|compound|END_ENTITY	Increased hepatic levels of the insulin_receptor inhibitor , PC-1 / NPP1 , induce insulin resistance and glucose_intolerance .
19374858	0	PC-1	67,71	insulin_receptor	28,44	PC-1	insulin receptor	5167	3643	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Evidence that inhibition of insulin_receptor signaling activity by PC-1 / ENPP1 is dependent on its enzyme activity .
7673181	0	PC-1	50,54	insulin_receptor	14,30	PC-1	insulin receptor	5167	3643	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of insulin_receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine_triphosphate or the generation of adenosine .
9648833	0	PC-1	152,156	insulin_receptor	196,212	PC-1	insulin receptor	5167	3643	Gene	Gene	factor|nsubj|START_ENTITY factor|nmod|signaling signaling|compound|END_ENTITY	Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects : evidence that PC-1 may be an intrinsic factor in impaired insulin_receptor signaling .
11004006	0	PC-1	77,81	tissue-nonspecific_alkaline_phosphatase	11,50	PC-1	tissue-nonspecific alkaline phosphatase	18605(Tax:10090)	11647(Tax:10090)	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Osteoblast tissue-nonspecific_alkaline_phosphatase antagonizes and regulates PC-1 .
17201255	0	PC-3	57,61	VEGF	27,31	PC-3	VEGF	57332	7422	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- RNA interference inhibits VEGF expression and growth of PC-3 in prostate_carcinoma -RSB- .
24190424	0	PC-3	28,32	c-Abl	10,15	PC-3	c-Abl	57332	25	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Decreased c-Abl activity in PC-3 and LNCaP_prostate_cancer cells overexpressing the early growth response-1 protein .
16365062	0	PC-3	127,131	interleukin-8	88,101	PC-3	interleukin-8	57332	3576	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Soy isoflavones alter expression of genes associated with cancer progression , including interleukin-8 , in androgen-independent PC-3 human prostate_cancer cells .
1367039	0	PC-8	100,104	proliferation_suppressing_factor	36,68	PC-8	proliferation suppressing factor	9159	3490	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and some properties of proliferation_suppressing_factor from human lung_adenocarcinoma PC-8 .
1436659	0	PC1	103,106	PC1	41,44	PC1	PC1	281967(Tax:9913)	281967(Tax:9913)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Differential subcellular distribution of PC1 , PC2 and furin in bovine adrenal medulla and secretion of PC1 and PC2 from this tissue .
1436659	0	PC1	41,44	PC1	103,106	PC1	PC1	281967(Tax:9913)	281967(Tax:9913)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Differential subcellular distribution of PC1 , PC2 and furin in bovine adrenal medulla and secretion of PC1 and PC2 from this tissue .
1397279	0	PC1	95,98	PC2	57,60	PC1	PC2	5122	5126	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC .
7595540	0	PC1	60,63	Pro-thyrotropin-releasing_hormone	0,33	PC1	Pro-thyrotropin-releasing hormone	85496(Tax:10116)	25569(Tax:10116)	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Pro-thyrotropin-releasing_hormone processing by recombinant PC1 .
10630414	0	PC1	39,42	prohormone_convertase_1	14,37	PC1	prohormone convertase 1	18548(Tax:10090)	18548(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of prohormone_convertase_1 -LRB- PC1 -RRB- by gp130-related cytokines .
11120670	0	PC1	39,42	prohormone_convertase_1	14,37	PC1	prohormone convertase 1	25204(Tax:10116)	25204(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of prohormone_convertase_1 -LRB- PC1 -RRB- by thyroid hormone .
16274843	0	PC1	39,42	prohormone_convertase_1	14,37	PC1	prohormone convertase 1	5122	5122	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of prohormone_convertase_1 -LRB- PC1 -RRB- expression in cholecystokinin -LRB- CCK -RRB- expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted .
7883050	0	PC1	72,75	secretoneurin	93,106	PC1	secretoneurin	5122	7857	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|END_ENTITY	Processing of secretogranin_II by prohormone convertases : importance of PC1 in generation of secretoneurin .
1397279	0	PC2	57,60	PC1	95,98	PC2	PC1	5126	5122	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC .
15585599	0	PC2	146,149	PC2	47,50	PC2	PC2	25121(Tax:10116)	25121(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter .
15585599	0	PC2	47,50	PC2	146,149	PC2	PC2	25121(Tax:10116)	25121(Tax:10116)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter .
19223471	0	PC2	49,52	Pax6	0,4	PC2	Pax6	5126	5080	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2 .
7615876	0	PC2	27,30	prohormone_convertase	5,26	PC2	prohormone convertase	5126	5126	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Frog prohormone_convertase PC2 mRNA has a mammalian-like expression pattern in the central nervous system and is colocalized with a subset of thyrotropin-releasing_hormone-expressing neurons .
12191492	0	PC2	91,94	proprotein_convertase_2	66,89	PC2	proprotein convertase 2	5126	5126	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of a repressor element in the promoter region of proprotein_convertase_2 -LRB- PC2 -RRB- gene .
7575410	0	PC2	38,41	secretogranin_II	59,75	PC2	secretogranin II	25121(Tax:10116)	24765(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Characterization of the endopeptidase PC2 activity towards secretogranin_II in stably transfected PC12 cells .
14614908	0	PC2	26,29	somatostatin-14	82,97	PC2	somatostatin-14	5126	6750	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer 's _ disease .
25917740	0	PC3	113,116	Akt1	51,55	PC3	Akt1	5122	207	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Enhanced Sensitivity to Sunitinib by Inhibition of Akt1 Expression in Human Castration-resistant Prostate Cancer PC3 Cells Both In Vitro and In Vivo .
25917740	0	PC3	113,116	Akt1	51,55	PC3	Akt1	5122	207	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Enhanced Sensitivity to Sunitinib by Inhibition of Akt1 Expression in Human Castration-resistant Prostate Cancer PC3 Cells Both In Vitro and In Vivo .
21373373	0	PC3	115,118	ETV4	13,17	PC3	ETV4	5122	2118	Gene	Gene	cells|compound|START_ENTITY required|nmod|cells required|nsubjpass|END_ENTITY	The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells .
22206665	0	PC3	87,90	MDR1	130,134	PC3	MDR1	5122	5243	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	ETS1 promotes chemoresistance and invasion of paclitaxel-resistant , hormone-refractory PC3 prostate cancer cells by up-regulating MDR1 and MMP9 expression .
24216994	0	PC3	86,89	Osteopontin	0,11	PC3	Osteopontin	5122	6696	Gene	Gene	Cells|compound|START_ENTITY Associations|nmod|Cells END_ENTITY|dep|Associations	Osteopontin and MMP9 : Associations with VEGF Expression/Secretion and Angiogenesis in PC3 Prostate_Cancer Cells .
18573234	0	PC3	71,74	SIRT1	11,16	PC3	SIRT1	5122	23411	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for SIRT1 in cell growth and chemoresistance in prostate_cancer PC3 and DU145 cells .
16425184	0	PC3	62,65	Skp2	54,58	PC3	Skp2	5122	6502	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
9087795	0	PC3	77,80	bombesin	29,37	PC3	bombesin	57332	2922	Gene	Gene	proliferation|nmod|START_ENTITY END_ENTITY|nmod|proliferation	In vitro characterization of bombesin and calcitonin on the proliferation of PC3 , DU 145 and LNCaP cancer prostatic cell lines .
11942325	0	PC3	155,158	epidermal_growth_factor	50,73	PC3	epidermal growth factor	57332	1950	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	The role of superoxide anion in the regulation of epidermal_growth_factor or the expression and proliferation of its receptor in prostate_cancer cell line PC3 .
8290389	0	PC3	63,66	epidermal_growth_factor	10,33	PC3	epidermal growth factor	57332	1950	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on prostate_cancer cell line PC3 growth and invasion .
24606484	0	PC3	62,65	inhibitor_of_DNA_binding_1	32,58	PC3	inhibitor of DNA binding 1	5122	3397	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Curcumin inhibits expression of inhibitor_of_DNA_binding_1 in PC3 cells and xenografts .
24846918	0	PC3	69,72	miR-145	12,19	PC3	miR-145	57332	406937	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of miR-145 on the migration and invasion of prostate_cancer PC3 cells by targeting DAB2 -RSB- .
20868520	0	PC3	50,53	osteopontin	35,46	PC3	osteopontin	5122	6696	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Regulation of Erk1/2 activation by osteopontin in PC3 human prostate_cancer cells .
9840345	0	PC3	106,109	p53	62,65	PC3	p53	57332	7157	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Role of superoxide anion on the proliferation and c-Ha-ras or p53 expression in prostate_cancer cell line PC3 .
10221563	0	PC3	56,59	tumor_necrosis_factor-alpha	25,52	PC3	tumor necrosis factor-alpha	57332	7124	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Cytotoxic sensitivity to tumor_necrosis_factor-alpha in PC3 and LNCaP prostatic_cancer cells is regulated by extracellular levels of SGP-2 -LRB- clusterin -RRB- .
9660958	0	PC4	24,27	TFIIIC	52,58	PC4	TFIIIC	10923	2975	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III .
17785449	0	PC4	64,67	p53	14,17	PC4	p53	10923	7157	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Activation of p53 function by human transcriptional coactivator PC4 : role of protein-protein interaction , DNA bending , and posttranslational modifications .
22826605	0	PCA-1	0,5	ALKBH3	6,12	PCA-1	ALKBH3	221120	221120	Gene	Gene	START_ENTITY|appos|contributes contributes|nsubj|END_ENTITY	PCA-1 / ALKBH3 contributes to pancreatic_cancer by supporting apoptotic resistance and angiogenesis .
19489685	0	PCA3	29,33	DD3	25,28	PCA3	DD3	50652	50652	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	The combination of urine DD3 -LRB- PCA3 -RRB- mRNA and PSA mRNA as molecular markers of prostate_cancer .
26945969	0	PCAF	0,4	Gli-1	114,119	PCAF	Gli-1	8850	2735	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	PCAF inhibits hepatocellular_carcinoma metastasis by inhibition of epithelial-mesenchymal transition by targeting Gli-1 .
16829519	0	PCAF	0,4	PTEN	15,19	PCAF	PTEN	8850	5728	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	PCAF modulates PTEN activity .
23468178	0	PCAF	0,4	Runx2	16,21	PCAF	Runx2	18519(Tax:10090)	12393(Tax:10090)	Gene	Gene	acetylates|nsubj|START_ENTITY acetylates|dobj|END_ENTITY	PCAF acetylates Runx2 and promotes osteoblast differentiation .
19773423	0	PCAF	33,37	cdk2	48,52	PCAF	cdk2	8850	1017	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The transcriptional co-activator PCAF regulates cdk2 activity .
24473064	0	PCAT-1	0,6	BRCA2	40,45	PCAT-1	BRCA2	100750225	675	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PCAT-1 , a long noncoding RNA , regulates BRCA2 and controls homologous recombination in cancer .
25425964	0	PCAT-1	24,30	cMyc	83,87	PCAT-1	cMyc	100750225	4609	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	The long non-coding RNA PCAT-1 promotes prostate_cancer cell proliferation through cMyc .
98133	0	PCB	77,80	arylhydrocarbon_hydroxylase	13,40	PCB	arylhydrocarbon hydroxylase	5091	1545	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of arylhydrocarbon_hydroxylase and UDP_glucuronosyl_transferase by PCB in hepatic cell cultures .
19433264	0	PCB	64,67	estrogen_receptor-alpha	19,42	PCB	estrogen receptor-alpha	5091	2099	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Protective role of estrogen_receptor-alpha on lower chlorinated PCB congener-induced DNA damage and repair in human tumoral breast cells .
9760199	0	PCBD	58,62	pterin-4alpha-carbinolamine_dehydratase	17,56	PCBD	pterin-4alpha-carbinolamine dehydratase	5092	5092	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the pterin-4alpha-carbinolamine_dehydratase -LRB- PCBD -RRB- gene cause a benign form of hyperphenylalaninemia .
22673507	0	PCBP1	35,40	THAP11	0,6	PCBP1	THAP11	5093	57215	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	THAP11 , a novel binding protein of PCBP1 , negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line .
22022391	0	PCBP2	0,5	IFN-a	41,46	PCBP2	IFN-a	5094	3440	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	PCBP2 enhances the antiviral activity of IFN-a against HCV by stabilizing the mRNA of STAT1 and STAT2 .
26722446	0	PCBP2	21,26	MicroRNA-214	0,12	PCBP2	MicroRNA-214	5094	406996	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-214 targets PCBP2 to suppress the proliferation and growth of glioma cells .
25717101	0	PCBP2	29,34	STAT3	9,14	PCBP2	STAT3	5094	6774	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Cellular STAT3 functions via PCBP2 to restrain EBV lytic activation in B lymphocytes .
26907686	0	PCBP2	20,25	p73	36,39	PCBP2	p53	18521(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RNA-Binding Protein PCBP2 regulates p73 expression and p73-dependent antioxidant defense .
20817677	0	PCBP4	78,83	p21	38,41	PCBP4	p21	59092(Tax:10090)	12575(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability .
24475254	0	PCC1	37,41	Pathogen_and_circadian_controlled_1	0,35	PCC1	Pathogen and circadian controlled 1	821788(Tax:3702)	821788(Tax:3702)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Pathogen_and_circadian_controlled_1 -LRB- PCC1 -RRB- protein is anchored to the plasma membrane and interacts with subunit 5 of COP9 signalosome in Arabidopsis .
10760271	0	PCDGF	45,50	PC_cell-derived_growth_factor	14,43	PCDGF	PC cell-derived growth factor	2896	2896	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of PC_cell-derived_growth_factor -LRB- PCDGF , epithelin/granulin precursor -RRB- expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast_carcinoma cell line MDA-MB-468 .
25590240	0	PCDH10	0,6	p53	16,19	PCDH10	p53	57575	7157	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	PCDH10 , a novel p53 transcriptional target in regulating cell migration .
23321168	0	PCDH10	58,64	protocadherin-10	40,56	PCDH10	protocadherin-10	57575	57575	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Clinical and prognostic significance of protocadherin-10 -LRB- PCDH10 -RRB- promoter methylation in bladder_cancer .
18408767	0	PCDH8	0,5	PAPC	28,32	PCDH8	PAPC	5100	5100	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	PCDH8 , the human homolog of PAPC , is a candidate tumor suppressor of breast_cancer .
23569129	0	PCDH8	42,47	protocadherin-8	25,40	PCDH8	protocadherin-8	5100	5100	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Clinical significance of protocadherin-8 -LRB- PCDH8 -RRB- promoter methylation in bladder_cancer .
12884975	0	PCDH8	37,42	protocadherin_8	20,35	PCDH8	protocadherin 8	5100	5100	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Screening the human protocadherin_8 -LRB- PCDH8 -RRB- gene in schizophrenia .
18298670	0	PCFS4	12,17	Pcf11p	63,69	PCFS4	Pcf11p	825827(Tax:3702)	851814(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Arabidopsis PCFS4 , a homologue of yeast polyadenylation factor Pcf11p , regulates FCA alternative processing and promotes flowering time .
20724482	0	PCFT	45,49	nuclear_respiratory_factor_1	76,104	PCFT	nuclear respiratory factor 1	113235	4899	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The obligatory intestinal folate transporter PCFT -LRB- SLC46A1 -RRB- is regulated by nuclear_respiratory_factor_1 .
23523425	0	PCGF1	40,45	BCOR	62,66	PCGF1	BCOR	84759	54880	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs .
24863970	0	PCK1	43,47	RAI1	37,41	PCK1	RAI1	5105	10743	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Three rare_diseases in one Sib pair : RAI1 , PCK1 , GRIN2B mutations associated with Smith-Magenis_Syndrome , cytosolic_PEPCK_deficiency and NMDA receptor glutamate insensitivity .
18772192	0	PCM-1	57,62	CEP290	0,6	PCM-1	CEP290	5108	80184	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium .
23345402	0	PCM1	0,4	Plk1	14,18	PCM1	Plk1	5108	5347	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry .
25119594	0	PCMT1	20,25	Hsa-miR-195	0,11	PCMT1	Hsa-miR-195	5110	406971	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Hsa-miR-195 targets PCMT1 in hepatocellular_carcinoma that increases_tumor life span .
15273770	0	PCNA	43,47	BAX	56,59	PCNA	BAX	5111	581	Gene	Gene	Bcl-2|dep|START_ENTITY Bcl-2|dep|END_ENTITY	Expression of biomolecular markers -LRB- Ki-67 , PCNA , Bcl-2 , BAX , BclX , VEGF -RRB- in breast_tumors .
21033101	0	PCNA	15,19	BCL-2	21,26	PCNA	BCL-2	5111	596	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of PCNA , BCL-2 , CD4 + , CD8 + in the adenoid tissues from children with secretory_otitis_media -RSB- .
9779488	0	PCNA	96,100	BCL-2	25,30	PCNA	BCL-2	5111	596	Gene	Gene	expression|appos|START_ENTITY expression|nmod|fraction fraction|amod|END_ENTITY	Correlated expression of BCL-2 protein , estrogen_receptor , cathepsin_D and low growth fraction -LRB- PCNA -RRB- in intracystic_papillary_breast_carcinoma .
23901102	0	PCNA	37,41	BRCA1	0,5	PCNA	BRCA1	5111	672	Gene	Gene	ubiquitination|nmod|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade .
18604733	0	PCNA	64,68	Bax	54,57	PCNA	Bax	5111	581	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Apoptosis and proliferation related molecules -LRB- Bcl-2 , Bax , p53 , PCNA -RRB- in papillary_microcarcinoma versus papillary_carcinoma of the thyroid .
18604733	0	PCNA	64,68	Bcl-2	47,52	PCNA	Bcl-2	5111	596	Gene	Gene	p53|dep|START_ENTITY p53|compound|END_ENTITY	Apoptosis and proliferation related molecules -LRB- Bcl-2 , Bax , p53 , PCNA -RRB- in papillary_microcarcinoma versus papillary_carcinoma of the thyroid .
26223641	0	PCNA	35,39	Bub1	0,4	PCNA	Bub1	5111	699	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Bub1 in complex with LANA recruits PCNA to regulate KSHV latent replication and DNA translesion synthesis .
12763212	0	PCNA	46,50	CD34	52,56	PCNA	CD34	5111	947	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
18263614	0	PCNA	32,36	CDKN1A	19,25	PCNA	CDKN1A	5111	1026	Gene	Gene	p21|nmod|START_ENTITY p21|appos|END_ENTITY	Interaction of p21 -LRB- CDKN1A -RRB- with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair .
11896603	0	PCNA	22,26	Cdc25C	0,6	PCNA	Cdc25C	5111	995	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cdc25C interacts with PCNA at G2/M transition .
24200966	0	PCNA	22,26	DDB2	0,4	PCNA	DDB2	5111	1643	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	DDB2 association with PCNA is required for its degradation after UV-induced DNA damage .
2886367	0	PCNA	8,12	DNA_polymerase_delta	35,55	PCNA	DNA polymerase delta	5111	5424	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Cyclin -LRB- PCNA , auxiliary protein of DNA_polymerase_delta -RRB- is a central component of the pathway -LRB- s -RRB- leading to DNA replication and cell division .
16629902	0	PCNA	42,46	DREF	64,68	PCNA	DREF	37290(Tax:7227)	34328(Tax:7227)	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Antagonistic regulation of the Drosophila PCNA gene promoter by DREF and Cut .
27084448	0	PCNA	27,31	DVC1	63,67	PCNA	DVC1	5111	83932	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human PCNA in complex with the PIP box of DVC1 .
16284070	0	PCNA	78,82	EGFR	56,60	PCNA	EGFR	25737(Tax:10116)	24329(Tax:10116)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Adenylate_cyclase_5 and KCa1 .1 channel are required for EGFR up-regulation of PCNA in native contractile rat basilar artery smooth muscle .
15569628	0	PCNA	30,34	ERK1/2	8,14	PCNA	ERK1/2	25737(Tax:10116)	50689;116590	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of ERK1/2 in FSH induced PCNA expression and steroidogenesis in granulosa cells .
10435153	0	PCNA	77,81	Epidermal_growth_factor_receptor	0,32	PCNA	Epidermal growth factor receptor	5111	1956	Gene	Gene	proliferating_cell_nuclear_antigen|appos|START_ENTITY END_ENTITY|appos|proliferating_cell_nuclear_antigen	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- , proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- and Ki-67 antigen in laryngeal epithelial lesions .
23939618	0	PCNA	0,4	Exo1	46,50	PCNA	Exo1	5111	9156	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	PCNA promotes processive DNA end resection by Exo1 .
26825464	0	PCNA	21,25	FANCM	0,5	PCNA	FANCM	5111	57697	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks .
8700517	0	PCNA	120,124	GADD45	61,67	PCNA	GADD45	18538(Tax:10090)	13197(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY protein|acl:relcl|interacts encodes|nmod|protein encodes|nsubj|MyD118 MyD118|acl|related related|nmod|END_ENTITY	The differentiation primary response gene MyD118 , related to GADD45 , encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1 .
12536397	0	PCNA	22,26	GFAP	16,20	PCNA	GFAP	5111	2670	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	-LSB- The changes of GFAP , PCNA after brain_contusion : an immunohistochemical study in forensic pathology -RSB- .
7478510	0	PCNA	112,116	Gadd45	22,28	PCNA	Gadd45	5111	1647	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
7478510	0	PCNA	112,116	Gadd45	83,89	PCNA	Gadd45	5111	1647	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
7478510	0	PCNA	34,38	Gadd45	83,89	PCNA	Gadd45	5111	1647	Gene	Gene	Gadd45|nmod|START_ENTITY interaction|nmod|Gadd45 interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
17626754	0	PCNA	24,28	HER-2	17,22	PCNA	HER-2	5111	2064	Gene	Gene	Bcl-2|dep|START_ENTITY Bcl-2|compound|END_ENTITY	-LSB- Correlations of HER-2 , PCNA , Bcl-2 , and Bax expression to prognosis of breast_cancer -RSB- .
22393258	0	PCNA	52,56	HMGN1	31,36	PCNA	HMGN1	5111	3150	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin .
12763212	0	PCNA	46,50	K-ras	27,32	PCNA	K-ras	5111	3845	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
21911365	0	PCNA	95,99	Mgs1	30,34	PCNA	Mgs1	5111	855503(Tax:4932)	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA .
10828065	0	PCNA	76,80	MyD118	20,26	PCNA	MyD118	5111	4616	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of MyD118 , Gadd45 , and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- interacting domains .
8592922	0	PCNA	55,59	P-105_and_p-120	61,76	PCNA	P-105 and p-120	5111	4790;4839	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	-LSB- Ag-NORs , nucleus-nucleolus-associated antigens -LRB- Ki67 , PCNA , P-105_and_p-120 -RRB- : prognostic markers of meningioma recurrence -RSB- .
22073260	0	PCNA	132,136	P50	0,3	PCNA	P50	5111	4790	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	P50 , the small subunit of DNA_polymerase_delta , is required for mediation of the interaction of polymerase delta subassemblies with PCNA .
7478510	0	PCNA	112,116	PCNA	34,38	PCNA	PCNA	5111	5111	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|Gadd45 Gadd45|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
7478510	0	PCNA	34,38	PCNA	112,116	PCNA	PCNA	5111	5111	Gene	Gene	Gadd45|nmod|START_ENTITY interaction|nmod|Gadd45 interaction|nmod|END_ENTITY	Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA .
23939377	0	PCNA	108,112	PI3K	0,4	PCNA	PI3K	5111	5293	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA .
15705097	0	PCNA	127,131	Proliferating-cell_nuclear_antigen	0,34	PCNA	Proliferating-cell nuclear antigen	5111	5111	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Proliferating-cell_nuclear_antigen -LRB- PCNA -RRB- as an independent prognostic marker in patients after prostatectomy : a comparison of PCNA and Ki-67 .
23201573	0	PCNA	71,75	Proliferating_Cell_Nuclear_Antigen	35,69	PCNA	Proliferating Cell Nuclear Antigen	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation at tyrosine 114 of Proliferating_Cell_Nuclear_Antigen -LRB- PCNA -RRB- is required for adipogenesis in response to high fat diet .
11578374	0	PCNA	36,40	Proliferating_cell_nuclear_antigen	0,34	PCNA	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- immunoreactivity in ovarian_serous_and_mucinous_neoplasms : diagnostic and prognostic value .
16584090	0	PCNA	36,40	Proliferating_cell_nuclear_antigen	0,34	PCNA	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in pituitary_adenomas : relationship to the endocrine phenotype of adenoma .
7520574	0	PCNA	36,40	Proliferating_cell_nuclear_antigen	0,34	PCNA	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression of megakaryocytopoiesis in normal human bone marrow and reactive lesions with special emphasis on HIV-myelopathy .
8105046	0	PCNA	36,40	Proliferating_cell_nuclear_antigen	0,34	PCNA	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression as a prognostic indicator for renal_cell_carcinoma : comparison with tumour grade , mitotic index , and silver-staining nucleolar organizer region numbers .
8907001	0	PCNA	36,40	Proliferating_cell_nuclear_antigen	0,34	PCNA	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in oral_squamous_cell_carcinoma - an aid to conventional histological grading ?
19023449	0	PCNA	0,4	Prox1	20,25	PCNA	Prox1	373984(Tax:9031)	395802(Tax:9031)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PCNA interacts with Prox1 and represses its transcriptional activity .
16857592	0	PCNA	28,32	REV1	0,4	PCNA	REV1	373984(Tax:9031)	418703(Tax:9031)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	REV1 protein interacts with PCNA : significance of the REV1 BRCT domain in vitro and in vivo .
16857592	0	PCNA	28,32	REV1	54,58	PCNA	REV1	373984(Tax:9031)	418703(Tax:9031)	Gene	Gene	interacts|nmod|START_ENTITY interacts|dep|significance significance|nmod|domain domain|compound|END_ENTITY	REV1 protein interacts with PCNA : significance of the REV1 BRCT domain in vitro and in vivo .
26795561	0	PCNA	14,18	REV1	0,4	PCNA	REV1	5111	51455	Gene	Gene	monoubiquitination|compound|START_ENTITY promotes|dobj|monoubiquitination promotes|nsubj|END_ENTITY	REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18 .
24674623	0	PCNA	4,8	Rad2p	27,32	PCNA	Rad2p	5111	2237	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The PCNA binding domain of Rad2p plays a role in mutagenesis by modulating the cell cycle in response to DNA damage .
24376557	0	PCNA	4,8	Rad54	45,50	PCNA	Rad54	5111	8438	Gene	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	The PCNA interaction protein box sequence in Rad54 is an integral part of its ATPase domain and is required for efficient DNA repair and recombination .
12919743	0	PCNA	26,30	Ren	79,82	PCNA	Ren	5111	5972	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Dual interaction of plant PCNA with geminivirus replication accessory protein -LRB- Ren -RRB- and viral replication protein -LRB- Rep -RRB- .
12919743	0	PCNA	26,30	Rep	115,118	PCNA	Rep	5111	956401(Tax:10831)	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Dual interaction of plant PCNA with geminivirus replication accessory protein -LRB- Ren -RRB- and viral replication protein -LRB- Rep -RRB- .
23747975	0	PCNA	15,19	Rev1	74,78	PCNA	Rev1	852385(Tax:4932)	854527(Tax:4932)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	NMR mapping of PCNA interaction with translesion_synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domain .
23761444	0	PCNA	33,37	Rev1	80,84	PCNA	Rev1	5111	51455	Gene	Gene	fusions|compound|START_ENTITY mediated|nmod|fusions tolerance|acl|mediated dependent|nsubj|tolerance dependent|nmod|END_ENTITY	DNA-damage tolerance mediated by PCNA * Ub fusions in human cells is dependent on Rev1 but not Pol .
23149855	0	PCNA	40,44	SUUR	11,15	PCNA	SUUR	37290(Tax:7227)	45739(Tax:7227)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner .
15931174	0	PCNA	14,18	Srs2	28,32	PCNA	Srs2	852385(Tax:4932)	853353(Tax:4932)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase .
15273770	0	PCNA	43,47	VEGF	67,71	PCNA	VEGF	5111	7422	Gene	Gene	Bcl-2|dep|START_ENTITY Bcl-2|dep|END_ENTITY	Expression of biomolecular markers -LRB- Ki-67 , PCNA , Bcl-2 , BAX , BclX , VEGF -RRB- in breast_tumors .
15543136	0	PCNA	58,62	Williams_syndrome_transcription_factor	4,42	PCNA	Williams syndrome transcription factor	5111	9031	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Williams_syndrome_transcription_factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci .
11451553	0	PCNA	55,59	bax	45,48	PCNA	bax	5111	581	Gene	Gene	MI|compound|START_ENTITY p53|dep|MI p53|dep|END_ENTITY	The importance of biological factors -LRB- bcl-2 , bax , p53 , PCNA , MI , HPV and angiogenesis -RRB- in invasive cervical_cancer .
10465333	0	PCNA	44,48	bcl-2	50,55	PCNA	bcl-2	5111	596	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemically stained markers -LRB- p53 , PCNA , bcl-2 -RRB- in dysplastic_lesions of the larynx .
12763212	0	PCNA	46,50	bcl-2	39,44	PCNA	bcl-2	5111	596	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
22238610	0	PCNA	51,55	c-Abl	62,67	PCNA	c-Abl	5111	25	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of proliferation cell nuclear antigen -LRB- PCNA -RRB- with c-Abl in cell proliferation and response to DNA damages in breast_cancer .
12760717	0	PCNA	56,60	c-erbB-2	67,75	PCNA	c-erbB-2	5111	2064	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Helicobacter_pylori_infection affects the expression of PCNA , p53 , c-erbB-2 and Bcl-2 in the human gastric mucosa .
14598611	0	PCNA	115,119	c-erbB-2	170,178	PCNA	c-erbB-2	5111	2064	Gene	Gene	Ki67|dep|START_ENTITY correlation|appos|Ki67 correlation|appos|END_ENTITY	Immunohistochemical study of apoptosis-related Bcl-2 protein and its correlation with proliferation indices -LRB- Ki67 , PCNA -RRB- , tumor suppressor genes -LRB- p53 , pRb -RRB- , the oncogene c-erbB-2 , sex steroid hormone receptors and other clinicopathological features , in normal , hyperplastic and neoplastic endometrium .
9779488	0	PCNA	96,100	cathepsin_D	59,70	PCNA	cathepsin D	5111	1509	Gene	Gene	expression|appos|START_ENTITY expression|nmod|fraction fraction|amod|END_ENTITY	Correlated expression of BCL-2 protein , estrogen_receptor , cathepsin_D and low growth fraction -LRB- PCNA -RRB- in intracystic_papillary_breast_carcinoma .
2415394	0	PCNA	28,32	cyclin	20,26	PCNA	cyclin	5111	5111	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	S-phase patterns of cyclin -LRB- PCNA -RRB- antigen staining resemble topographical patterns of DNA synthesis .
2419706	0	PCNA	28,32	cyclin	20,26	PCNA	cyclin	5111	5111	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Nuclear patterns of cyclin -LRB- PCNA -RRB- antigen distribution subdivide S-phase in cultured cells -- some applications of PCNA antibodies .
2889855	0	PCNA	90,94	cyclin	82,88	PCNA	cyclin	5111	5111	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	PCNA -LRB- cyclin -RRB- autoantibodies and monoclonal antibodies reveal similar patterns of cyclin -LRB- PCNA -RRB- antigen staining in human cultured cells .
11019942	0	PCNA	16,20	cyclin-D1	5,14	PCNA	cyclin-D1	5111	595	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	p53 , cyclin-D1 , PCNA , AgNOR expression in squamous_cell_cancer_of_the_lip : a multicenter study .
16491347	0	PCNA	55,59	cyclin_A	45,53	PCNA	cyclin A	5111	890	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
16245643	0	PCNA	103,107	cytokeratin_19	36,50	PCNA	cytokeratin 19	5111	3880	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of cytokeratin_19 , involucrin and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in cultured human gingival epithelial sheets .
16459887	0	PCNA	103,107	cytokeratin_19	36,50	PCNA	cytokeratin 19	5111	3880	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of cytokeratin_19 , involucrin and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in cultured human gingival epithelial sheets .
14676842	0	PCNA	128,132	exonuclease_1	26,39	PCNA	exonuclease 1	5111	9156	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human exonuclease_1 in complex with mismatch repair proteins , subcellular localization and association with PCNA .
11274057	0	PCNA	30,34	hMSH3	0,5	PCNA	hMSH3	5111	4437	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci .
14558955	0	PCNA	60,64	nm23	15,19	PCNA	nm23	5111	4830	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of nm23 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in human brain_gliomas and their significance -RSB- .
18234018	0	PCNA	79,83	p-53	85,89	PCNA	p-53	5111	7157	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Molecular markers of cancer in cartilaginous_fish : immunocytochemical study of PCNA , p-53 , myc and ras expression in neoplastic and hyperplastic tissues from free ranging blue sharks , Prionace glauca -LRB- L. -RRB- .
12854173	0	PCNA	15,19	p21	26,29	PCNA	p21	5111	1026	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|appos|END_ENTITY	Expressions of PCNA , p53 , p21 -LRB- WAF-1 -RRB- and cell proliferation in fetal esophageal epithelia : comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal_cancer in Henan , _ North_China .
16491347	0	PCNA	55,59	p21	92,95	PCNA	p21	5111	1026	Gene	Gene	Ki67|dep|START_ENTITY Ki67|amod|inhibitors inhibitors|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
16491347	0	PCNA	55,59	p27	97,100	PCNA	p27	5111	3429	Gene	Gene	Ki67|dep|START_ENTITY Ki67|amod|inhibitors inhibitors|dep|p21 p21|nummod|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
11268218	0	PCNA	37,41	p300	26,30	PCNA	p300	18538(Tax:10090)	328572(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis .
18263614	0	PCNA	32,36	p300	89,93	PCNA	p300	5111	2033	Gene	Gene	p21|nmod|START_ENTITY Interaction|nmod|p21 regulates|nsubj|Interaction regulates|dobj|activity activity|nmod|END_ENTITY	Interaction of p21 -LRB- CDKN1A -RRB- with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair .
10347785	0	PCNA	62,66	p53	12,15	PCNA	p53	5111	7157	Gene	Gene	using|dobj|START_ENTITY expression|acl|using expression|compound|END_ENTITY	Analysis of p53 expression and proliferative assessment using PCNA in localized prostate_carcinoma .
11019942	0	PCNA	16,20	p53	0,3	PCNA	p53	5111	7157	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	p53 , cyclin-D1 , PCNA , AgNOR expression in squamous_cell_cancer_of_the_lip : a multicenter study .
11451553	0	PCNA	55,59	p53	50,53	PCNA	p53	5111	7157	Gene	Gene	MI|compound|START_ENTITY END_ENTITY|dep|MI	The importance of biological factors -LRB- bcl-2 , bax , p53 , PCNA , MI , HPV and angiogenesis -RRB- in invasive cervical_cancer .
12217864	0	PCNA	22,26	p53	30,33	PCNA	p53	5111	7157	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Spatial repression of PCNA by p53 during kidney development .
12760717	0	PCNA	56,60	p53	62,65	PCNA	p53	5111	7157	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Helicobacter_pylori_infection affects the expression of PCNA , p53 , c-erbB-2 and Bcl-2 in the human gastric mucosa .
12763212	0	PCNA	46,50	p53	34,37	PCNA	p53	5111	7157	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
12807244	0	PCNA	215,219	p53	168,171	PCNA	p53	5111	7157	Gene	Gene	correlation|appos|START_ENTITY correlation|nmod|pRb pRb|dep|END_ENTITY	Immunohistochemical expression of heat_shock protein 27 , in normal hyperplastic and neoplastic endometrium : correlation with estrogen and progesterone_receptor status , p53 , pRb and proliferation associated indices -LRB- PCNA , MIB1 -RRB- .
12854173	0	PCNA	15,19	p53	21,24	PCNA	p53	5111	7157	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|appos|END_ENTITY	Expressions of PCNA , p53 , p21 -LRB- WAF-1 -RRB- and cell proliferation in fetal esophageal epithelia : comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal_cancer in Henan , _ North_China .
14598611	0	PCNA	115,119	p53	146,149	PCNA	p53	5111	7157	Gene	Gene	Ki67|dep|START_ENTITY correlation|appos|Ki67 correlation|appos|genes genes|dep|END_ENTITY	Immunohistochemical study of apoptosis-related Bcl-2 protein and its correlation with proliferation indices -LRB- Ki67 , PCNA -RRB- , tumor suppressor genes -LRB- p53 , pRb -RRB- , the oncogene c-erbB-2 , sex steroid hormone receptors and other clinicopathological features , in normal , hyperplastic and neoplastic endometrium .
14658589	1	PCNA	193,197	p53	137,140	PCNA	p53	5111	7157	Gene	Gene	status|appos|START_ENTITY status|compound|END_ENTITY	An immunohistochemical study including correlations with p53 , steroid receptor status and proliferative indices -LRB- PCNA , MIB1 -RRB- .
15274338	1	PCNA	162,166	p53	109,112	PCNA	p53	5111	7157	Gene	Gene	indices|appos|START_ENTITY status|appos|indices steroid|nsubj|status steroid|dep|Correlation Correlation|nmod|END_ENTITY	Correlation with p53 , steroid receptor status , proliferative indices -LRB- PCNA , MIB1 -RRB- and survival .
15772596	0	PCNA	66,70	p53	22,25	PCNA	p53	5111	7157	Gene	Gene	expressions|appos|START_ENTITY expressions|nmod|END_ENTITY	Higher expressions of p53 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in atrophic oral_lichen_planus and patients with areca quid chewing .
15902973	0	PCNA	99,103	p53	12,15	PCNA	p53	18538(Tax:10090)	22060(Tax:10090)	Gene	Gene	protooncogene|appos|START_ENTITY protooncogene|compound|END_ENTITY	Analysis of p53 tumor suppressor gene , H-ras protooncogene and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in squamous_cell_carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen -LRB- 8-MOP -RRB- and UVA radiation -LRB- PUVA therapy -RRB- .
17625704	0	PCNA	36,40	p53	43,46	PCNA	p53	5111	7157	Gene	Gene	Proliferating_cell_nuclear_antigen|appos|START_ENTITY Proliferating_cell_nuclear_antigen|dep|expression expression|compound|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- , p53 and MDM2 expression in Hodgkins_disease .
7910135	0	PCNA	88,92	p53	32,35	PCNA	p53	5111	7157	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|oncoprotein oncoprotein|compound|END_ENTITY	Immunohistochemical analysis of p53 oncoprotein and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the cervix uteri .
7915517	0	PCNA	34,38	p53	51,54	PCNA	p53	5111	7157	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Transcriptional regulation of the PCNA promoter by p53 .
9187909	0	PCNA	126,130	p53	0,3	PCNA	p53	5111	7157	Gene	Gene	grade|appos|START_ENTITY correlation|nmod|grade expression|dep|correlation expression|compound|END_ENTITY	p53 and c-jun expression in urinary_bladder_transitional_cell_carcinoma : correlation with proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- histological grade and clinical stage .
9694596	0	PCNA	75,79	p53	34,37	PCNA	p53	5111	7157	Gene	Gene	proliferating_cell_nuclear_antigen|appos|START_ENTITY END_ENTITY|appos|proliferating_cell_nuclear_antigen	Immunohistochemical evaluation of p53 , proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- and bcl-2 expression during bacillus Calmette-Guerin -LRB- BCG -RRB- intravesical instillation therapy for superficial bladder_cancers .
9713468	0	PCNA	68,72	p53	91,94	PCNA	p53	5111	7157	Gene	Gene	index|compound|START_ENTITY index|dep|index index|dep|karyotype karyotype|dep|END_ENTITY	Prognostic significance of different biological markers -LRB- DNA index , PCNA index , apoptosis , p53 , karyotype -RRB- in 126 adenocarcinoma_gastric_biopsies .
12807244	0	PCNA	215,219	pRb	173,176	PCNA	pRb	5111	5925	Gene	Gene	correlation|appos|START_ENTITY correlation|nmod|END_ENTITY	Immunohistochemical expression of heat_shock protein 27 , in normal hyperplastic and neoplastic endometrium : correlation with estrogen and progesterone_receptor status , p53 , pRb and proliferation associated indices -LRB- PCNA , MIB1 -RRB- .
10468892	0	PCNA	70,74	proliferating_cell_nuclear_antigen	34,68	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Image cytometric DNA analysis and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in transitional cell carcinoma_of_the_bladder .
10821433	0	PCNA	87,91	proliferating_cell_nuclear_antigen	40,74	PCNA	proliferating cell nuclear antigen	25737(Tax:10116)	25737(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Butyrate inhibits proliferation-induced proliferating_cell_nuclear_antigen expression -LRB- PCNA -RRB- in rat vascular smooth muscle cells .
10899674	0	PCNA	50,54	proliferating_cell_nuclear_antigen	14,48	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in oral_submucous_fibrosis , oral epithelial_hyperkeratosis and oral_epithelial_dysplasia in Taiwan .
11130245	0	PCNA	54,58	proliferating_cell_nuclear_antigen	18,52	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in leukemia cell lines HL-60 and K-562 at the light and electron microscope level .
11578332	0	PCNA	29,33	proliferating_cell_nuclear_antigen	35,69	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of PCNA -LRB- proliferating_cell_nuclear_antigen -RRB- in normal and abnormal endometrium .
1347557	0	PCNA	66,70	proliferating_cell_nuclear_antigen	30,64	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	-LSB- Immunohistochemical study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in gynecological tumors and their related lesions -RSB- .
1348631	0	PCNA	82,86	proliferating_cell_nuclear_antigen	46,80	PCNA	proliferating cell nuclear antigen	25737(Tax:10116)	25737(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of the 5 ' flanking region of the rat proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene .
1360848	0	PCNA	87,91	proliferating_cell_nuclear_antigen	51,85	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Influence of preoperative dexamethasone therapy on proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in comparison to other parameters in meningiomas .
1374182	0	PCNA	52,56	proliferating_cell_nuclear_antigen	16,50	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	Relationship of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in prostatic_carcinomas to various clinical parameters .
15857596	0	PCNA	56,60	proliferating_cell_nuclear_antigen	20,54	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in infiltrating ductal_carcinoma breast .
16269167	0	PCNA	65,69	proliferating_cell_nuclear_antigen	29,63	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in duckling liver fed with aflatoxin_B1 and esterified glucomannan .
16673899	0	PCNA	48,52	proliferating_cell_nuclear_antigen	12,46	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- associated with DNA .
1672277	0	PCNA	113,117	proliferating_cell_nuclear_antigen	77,111	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of an enhancer-like structure in the promoter region of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene .
1694073	0	PCNA	56,60	proliferating_cell_nuclear_antigen	20,54	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The promoter of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene is active in serum-derived cells .
1698875	0	PCNA	90,94	proliferating_cell_nuclear_antigen	54,88	PCNA	proliferating cell nuclear antigen	100339381(Tax:9986)	100339381(Tax:9986)	Gene	Gene	assay|appos|START_ENTITY assay|nmod|END_ENTITY	A sandwich type enzyme-linked immunosorbent assay for proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- / cyclin using monoclonal antibodies .
17098349	0	PCNA	53,57	proliferating_cell_nuclear_antigen	17,51	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- is closely associated with high-risk human_papillomavirus _ -LRB- HPV -RRB- and progression of cervical_intraepithelial_neoplasia -LRB- CIN -RRB- , but does not predict disease outcome in cervical_cancer .
17219721	0	PCNA	72,76	proliferating_cell_nuclear_antigen	36,70	PCNA	proliferating cell nuclear antigen	692192(Tax:9823)	692192(Tax:9823)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the pig ovary .
1970785	0	PCNA	62,66	proliferating_cell_nuclear_antigen	26,60	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The promoter of the human proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene is bidirectional .
21541548	0	PCNA	56,60	proliferating_cell_nuclear_antigen	20,54	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic value of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in unresectable hepatocellular_carcinoma .
26537947	0	PCNA	56,60	proliferating_cell_nuclear_antigen	20,54	PCNA	proliferating cell nuclear antigen	852385(Tax:4932)	852385(Tax:4932)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- from pathogenic yeast Candida_albicans and its functional analyses in S. _ Cerevisiae .
2869966	0	PCNA	83,87	proliferating_cell_nuclear_antigen	47,81	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Immunochemical and biochemical analysis of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in HeLa cells .
7474637	0	PCNA	51,55	proliferating_cell_nuclear_antigen	15,49	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in renal_cell_carcinoma -RSB- .
7596084	0	PCNA	65,69	proliferating_cell_nuclear_antigen	29,63	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	-LSB- Histochemical expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- for pre and post chemotherapeutic bladder_cancer -RSB- .
7603742	0	PCNA	112,116	proliferating_cell_nuclear_antigen	76,110	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Comparison of silver-staining nucleolar organizer region -LRB- AgNOR -RRB- counts and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in reactive mesothelial_hyperplasia and malignant_mesothelioma .
7789227	0	PCNA	51,55	proliferating_cell_nuclear_antigen	15,49	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in squamous_cell_carcinoma_of_the_oral_cavity -RSB- .
7835840	0	PCNA	63,67	proliferating_cell_nuclear_antigen	27,61	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in gliomas .
7907610	0	PCNA	55,59	proliferating_cell_nuclear_antigen	19,53	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p53 , c-myc p62 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in non-Hodgkin 's _ lymphomas .
7910645	0	PCNA	162,166	proliferating_cell_nuclear_antigen	126,160	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Expression of squamous_cell_carcinoma-associated antigen in bladder_cancer cells -- a comparative study with the expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- -RSB- .
7911055	0	PCNA	65,69	proliferating_cell_nuclear_antigen	29,63	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Clinicopathological study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- of hepatocytes in primary_biliary_cirrhosis .
7911730	0	PCNA	70,74	proliferating_cell_nuclear_antigen	34,68	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in intracranial_glioma and meningioma .
7919464	0	PCNA	47,51	proliferating_cell_nuclear_antigen	11,45	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The use of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression and intraepithelial lymphocyte count in the differential diagnosis of inflammatory_bowel_disease .
7919730	0	PCNA	56,60	proliferating_cell_nuclear_antigen	20,54	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in cancer of the ampulla of vater in terms of prognosis .
7987078	1	PCNA	207,211	proliferating_cell_nuclear_antigen	171,205	PCNA	proliferating cell nuclear antigen	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	A comparative study using immunohistochemical detection of bromodeoxyuridine -LRB- BrdU -RRB- incorporation and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression .
8096489	0	PCNA	65,69	proliferating_cell_nuclear_antigen	29,63	PCNA	proliferating cell nuclear antigen	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in endometrial_carcinoma with argyrophil cells .
8099466	0	PCNA	63,67	proliferating_cell_nuclear_antigen	27,61	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in non-small_cell_lung_cancer .
8102179	0	PCNA	50,54	proliferating_cell_nuclear_antigen	14,48	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in dysplasia of the bronchial epithelium .
8587571	0	PCNA	61,65	proliferating_cell_nuclear_antigen	25,59	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Correlationship between proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression and clinicopathological factors in colorectal_cancer -RSB- .
8606541	0	PCNA	52,56	proliferating_cell_nuclear_antigen	16,50	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in gastric_cancer in relation to lymph node metastasis .
8634790	0	PCNA	49,53	proliferating_cell_nuclear_antigen	13,47	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Analysis of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in 24 cases of primary non-small_cell_pulmonary_carcinomas and correlation with survival -RSB- .
8745457	0	PCNA	51,55	proliferating_cell_nuclear_antigen	15,49	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in premalignant_lesions of laryngeal epithelium -RSB- .
8849474	0	PCNA	49,53	proliferating_cell_nuclear_antigen	13,47	PCNA	proliferating cell nuclear antigen	25737(Tax:10116)	25737(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Analysis of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in brain_tumors -RSB- .
8940694	0	PCNA	60,64	proliferating_cell_nuclear_antigen	24,58	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Study|appos|START_ENTITY Study|nmod|expression expression|nmod|END_ENTITY	-LSB- Study on expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in ovarian_cancer -RSB- .
9001344	0	PCNA	63,67	proliferating_cell_nuclear_antigen	27,61	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in squamous_cell_carcinoma of the esophagus .
9042536	0	PCNA	63,67	proliferating_cell_nuclear_antigen	27,61	PCNA	proliferating cell nuclear antigen	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the spinal cord of the hypomyelinated Jimpy mutant mice .
9076780	0	PCNA	48,52	proliferating_cell_nuclear_antigen	12,46	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in differentiating idiopathic_orbital_inflammatory disease and lymphoid proliferations .
9350310	0	PCNA	50,54	proliferating_cell_nuclear_antigen	14,48	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in supraglottic_carcinoma .
9388366	0	PCNA	157,161	proliferating_cell_nuclear_antigen	121,155	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- The relationship between the estimated tumor growth speed and indices of bromodeoxyuridine -LRB- BrdU -RRB- incorporation and the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in superficial bladder_cancer -RSB- .
9487740	0	PCNA	48,52	proliferating_cell_nuclear_antigen	12,46	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Increase of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in HPV-18 positive oral_squamous_cell_carcinomas .
9578731	0	PCNA	134,138	proliferating_cell_nuclear_antigen	98,132	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Immunohistochemical study of the proliferation of breast_cancer cells based on the expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- -RSB- .
9589044	0	PCNA	206,210	proliferating_cell_nuclear_antigen	170,204	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Immunohistochemical study on the progression of colorectal_cancer -- with respect to apoptotic index , expression of apoptosis-related gene products , and labeling index of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- -RSB- .
9612805	0	PCNA	48,52	proliferating_cell_nuclear_antigen	12,46	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in predicting biologic behavior of lymphoid infiltrates of the orbit and ocular adnexae .
9617618	0	PCNA	102,106	proliferating_cell_nuclear_antigen	66,100	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- The relationship between the production of interleukin-6 and the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in renal_cell_carcinoma -RSB- .
9713473	0	PCNA	46,50	proliferating_cell_nuclear_antigen	10,44	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Bcl-2 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression correlates with subsequent local recurrence in nasopharyngeal_carcinomas .
9799997	0	PCNA	60,64	proliferating_cell_nuclear_antigen	24,58	PCNA	proliferating cell nuclear antigen	5111	5111	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The prognostic value of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the advanced cancer_of_larynx .
8545595	0	PCNA	54,58	proliferative_cell_nuclear_antigen	18,52	PCNA	proliferative cell nuclear antigen	5111	5111	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the proliferative_cell_nuclear_antigen -LRB- PCNA -RRB- in adenocarcinoma_of_the_gallbladder , and its relationship to prognosis .
15479830	0	PCNA	0,4	rep	57,60	PCNA	rep	5111	991136(Tax:33726)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PCNA interacts with Indian mung_bean_yellow_mosaic_virus rep and downregulates Rep activity .
1362284	0	PCNA/Cyclin	52,63	proliferating_cell_nuclear_antigen	16,50	PCNA/Cyclin	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of proliferating_cell_nuclear_antigen -LRB- PCNA/Cyclin -RRB- in workshop cases of Hodgkin 's _ disease and non-Hodgkin 's _ lymphoma .
2566509	0	PCNA/cyclin	81,92	proliferating_cell_nuclear_antigen	45,79	PCNA/cyclin	proliferating cell nuclear antigen	394328(Tax:8355)	394328(Tax:8355)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Quantitation and subcellular localization of proliferating_cell_nuclear_antigen -LRB- PCNA/cyclin -RRB- in oocytes and eggs of Xenopus_laevis .
8105840	0	PCNA/cyclin	74,85	proliferating_cell_nuclear_antigen	38,72	PCNA/cyclin	proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The immunohistochemical expression of proliferating_cell_nuclear_antigen -LRB- PCNA/cyclin -RRB- in malignant and benign_epithelial_ovarian_neoplasms and correlation with prognosis .
8630339	0	PCNA_and_3	120,130	p34	98,101	PCNA and 3	p34	5111	79719	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	Genesis and evolution of high-ploidy tumour cells evaluated by means of the proliferation markers p34 -LRB- cdc2 -RRB- , cyclin_B1 , PCNA_and_3 -LSB- H -RSB- - thymidine .
18174396	0	PCNT	30,34	pericentrin	17,28	PCNT	pericentrin	5116	5116	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the pericentrin -LRB- PCNT -RRB- gene cause primordial dwarfism .
19448849	0	PCNT	41,45	pericentrin	28,39	PCNT	pericentrin	5116	5116	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Positive association of the pericentrin -LRB- PCNT -RRB- gene with major_depressive_disorder in the Japanese population .
19937158	0	PCNT	43,47	pericentrin	30,41	PCNT	pericentrin	5116	5116	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association study between the pericentrin -LRB- PCNT -RRB- gene and schizophrenia .
8771786	0	PCP	62,65	pollen_coat_protein	41,60	PCP	pollen coat protein	106300870	106300870	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Cloning of PCP1 , a member of a family of pollen_coat_protein -LRB- PCP -RRB- genes from Brassica_oleracea encoding novel cysteine-rich proteins involved in pollen-stigma interactions .
8333831	0	PCP	38,41	proteoglycan_core_protein	11,36	PCP	proteoglycan core protein	1634	1634	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in proteoglycan_core_protein -LRB- PCP -RRB- mRNA levels during HL-60 cell differentiation .
25286301	0	PCPE-1	55,61	procollagen_C-proteinase_enhancer-1	18,53	PCPE-1	procollagen C-proteinase enhancer-1	5118	5118	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	The NTR domain of procollagen_C-proteinase_enhancer-1 -LRB- PCPE-1 -RRB- mediates PCPE-1 binding to syndecans-1 , _ -2 _ and _ -4 as well as fibronectin .
25255477	0	PCSK9	32,37	ApoCIII	14,21	PCSK9	ApoCIII	255738	345	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ApoCIII : the next PCSK9 ?
26861255	0	PCSK9	35,40	C-reactive_protein	61,79	PCSK9	C-reactive protein	255738	1401	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effect of Monoclonal Antibodies to PCSK9 on high-sensitivity C-reactive_protein levels : A Meta-Analysis of 16 Randomized Controlled Treatment Arms .
26494228	0	PCSK9	0,5	CD36	14,18	PCSK9	CD36	100102(Tax:10090)	12491(Tax:10090)	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty_Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver .
26195630	0	PCSK9	36,41	CD81	16,20	PCSK9	CD81	255738	975	Gene	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Plasma membrane CD81 complexes with PCSK9 and LDLR and its levels are reduced by PCSK9 .
26195630	0	PCSK9	36,41	CD81	16,20	PCSK9	CD81	255738	975	Gene	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Plasma membrane CD81 complexes with PCSK9 and LDLR and its levels are reduced by PCSK9 .
26015437	0	PCSK9	33,38	CETP	4,8	PCSK9	CETP	255738	1071	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	New CETP Inhibitor K-312 Reduces PCSK9 Expression : A Potential Effect on LDL Cholesterol Metabolism .
15530918	0	PCSK9	64,69	Familial_Hypercholesterolemia	98,127	PCSK9	Familial Hypercholesterolemia	255738	3949	Gene	Gene	genes|compound|START_ENTITY involvement|nmod|genes involvement|nmod|END_ENTITY	No genetic linkage or molecular evidence for involvement of the PCSK9 , ARH or CYP7A1 genes in the Familial_Hypercholesterolemia phenotype in a sample of Danish families without pathogenic mutations in the LDL_receptor and apoB genes .
26632531	0	PCSK9	100,105	Familial_Hypercholesterolemia	18,47	PCSK9	Familial Hypercholesterolemia	255738	3949	Gene	Gene	Mutations|appos|START_ENTITY Kexin_Type_9|dep|Mutations Lipoprotein|dep|Kexin_Type_9 Lipoprotein|nmod|END_ENTITY	Lipoprotein -LRB- a -RRB- in Familial_Hypercholesterolemia With Proprotein_Convertase_Subtilisin / Kexin_Type_9 -LRB- PCSK9 -RRB- Gain-of-Function Mutations .
20048381	0	PCSK9	20,25	HNF1alpha	50,59	PCSK9	HNF1alpha	255738	6927	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2 : mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters .
20498851	0	PCSK9	63,68	LDLR	82,86	PCSK9	LDLR	100102(Tax:10090)	16835(Tax:10090)	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	A locked nucleic acid antisense oligonucleotide -LRB- LNA -RRB- silences PCSK9 and enhances LDLR expression in vitro and in vivo .
26824363	0	PCSK9	32,37	Leptin	10,16	PCSK9	Leptin	100102(Tax:10090)	16846(Tax:10090)	Gene	Gene	Replacement|nmod|START_ENTITY Replacement|compound|END_ENTITY	Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients .
26668321	0	PCSK9	99,104	Proprotein_Convertase_Subtilisin_Kexin_Type_9	52,97	PCSK9	Proprotein Convertase Subtilisin Kexin Type 9	255738	255738	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Suppressor_of_Cytokine_Signaling-3 -LRB- SOCS-3 -RRB- induces Proprotein_Convertase_Subtilisin_Kexin_Type_9 -LRB- PCSK9 -RRB- expression in hepatic HepG2 cell line .
26820367	0	PCSK9	49,54	SREBP2	63,69	PCSK9	SREBP2	255738	6721	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Is sEHi lowering LDL-C by reducing expression of PCSK9 through SREBP2 pathway ?
15178557	0	PCSK9	19,24	familial_hypercholesterolemia	124,153	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	START_ENTITY|appos|gene gene|acl|encoding encoding|dobj|convertase-1 convertase-1|acl|implicated implicated|nmod|END_ENTITY	Statins upregulate PCSK9 , the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial_hypercholesterolemia .
17435765	0	PCSK9	38,43	familial_hypercholesterolemia	70,99	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	studies|nmod|START_ENTITY linked|nsubj|studies linked|nmod|END_ENTITY	Structural and biophysical studies of PCSK9 and its mutants linked to familial_hypercholesterolemia .
17765244	0	PCSK9	56,61	familial_hypercholesterolemia	86,115	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	mutants|compound|START_ENTITY Identification|nmod|mutants associated|nsubj|Identification associated|nmod|END_ENTITY	Identification and characterization of two non-secreted PCSK9 mutants associated with familial_hypercholesterolemia in cohorts from New Zealand and South Africa .
19917273	0	PCSK9	38,43	familial_hypercholesterolemia	111,140	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	gene|compound|START_ENTITY R46L|nmod|gene has|nsubj|R46L has|dobj|impact impact|nmod|levels levels|nmod|cholesterol cholesterol|nmod|heterozygotes heterozygotes|compound|END_ENTITY	Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial_hypercholesterolemia heterozygotes .
22375030	0	PCSK9	17,22	familial_hypercholesterolemia	53,82	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of PCSK9 and phenotypic variability in familial_hypercholesterolemia .
24632287	0	PCSK9	16,21	familial_hypercholesterolemia	119,148	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	level|compound|START_ENTITY detrimental|nsubj|level detrimental|nmod|patients patients|nmod|END_ENTITY	Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial_hypercholesterolemia and heterozygous familial_hypercholesterolemia , irrespective of low-density_lipoprotein_receptor defects .
25014035	0	PCSK9	135,140	familial_hypercholesterolemia	48,77	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	mutation|appos|START_ENTITY caused|nmod|mutation caused|nsubj|features features|nmod|END_ENTITY	Genotypic and phenotypic features in homozygous familial_hypercholesterolemia caused by proprotein_convertase_subtilisin / kexin_type_9 -LRB- PCSK9 -RRB- gain-of-function mutation .
25313916	0	PCSK9	210,215	familial_hypercholesterolemia	132,161	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	assay|nmod|START_ENTITY development|nmod|assay kexin_9|dep|development kexin_9|nmod|lipoprotein-apheresis lipoprotein-apheresis|nmod|END_ENTITY	Removal of plasma mature and furin-cleaved proprotein_convertase_subtilisin / kexin_9 -LRB- PCSK9 -RRB- by low-density lipoprotein-apheresis in familial_hypercholesterolemia : development and application of a new assay for PCSK9 .
25313916	0	PCSK9	85,90	familial_hypercholesterolemia	132,161	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	kexin_9|appos|START_ENTITY kexin_9|nmod|lipoprotein-apheresis lipoprotein-apheresis|nmod|END_ENTITY	Removal of plasma mature and furin-cleaved proprotein_convertase_subtilisin / kexin_9 -LRB- PCSK9 -RRB- by low-density lipoprotein-apheresis in familial_hypercholesterolemia : development and application of a new assay for PCSK9 .
26371983	0	PCSK9	20,25	familial_hypercholesterolemia	63,92	PCSK9	familial hypercholesterolemia	255738	3949	Gene	Gene	levels|nummod|START_ENTITY levels|nmod|severity severity|nmod|END_ENTITY	The contribution of PCSK9 levels to the phenotypic severity of familial_hypercholesterolemia is independent of LDL_receptor genotype .
21147780	0	PCSK9	57,62	furin	22,27	PCSK9	furin	100102(Tax:10090)	18550(Tax:10090)	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	In vivo evidence that furin from hepatocytes inactivates PCSK9 .
17449864	0	PCSK9	9,14	low_density_lipoprotein_receptor	29,61	PCSK9	low density lipoprotein receptor	255738	3949	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Secreted PCSK9 downregulates low_density_lipoprotein_receptor through receptor-mediated endocytosis .
26085104	0	PCSK9	66,71	low_density_lipoprotein_receptor	92,124	PCSK9	low density lipoprotein receptor	100102(Tax:10090)	16835(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low_density_lipoprotein_receptor degradation but interact with each other .
19768174	0	PCSK9	80,85	proprotein_convertase_subtilisin_kexin-9	38,78	PCSK9	proprotein convertase subtilisin kexin-9	255738	255738	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Statins and ezetimibe modulate plasma proprotein_convertase_subtilisin_kexin-9 -LRB- PCSK9 -RRB- levels .
26183252	0	PCSK9	77,82	proprotein_convertase_subtilisin_kexin_9	35,75	PCSK9	proprotein convertase subtilisin kexin 9	255738	255738	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Effect of statin therapy on plasma proprotein_convertase_subtilisin_kexin_9 -LRB- PCSK9 -RRB- concentrations : a systematic review and meta-analysis of clinical trials .
9197417	0	PCTAIRE-1	21,30	p11_and_14-3-3	64,78	PCTAIRE-1	p11 and 14-3-3	18555(Tax:10090)	20194(Tax:10090)	Gene	Gene	START_ENTITY|nmod|proteins proteins|amod|END_ENTITY	The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11_and_14-3-3 proteins .
22798068	0	PCTAIRE1	52,60	BRSK2	26,31	PCTAIRE1	BRSK2	18555(Tax:10090)	75770(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Brain-selective_kinase_2 -LRB- BRSK2 -RRB- phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic b-cells .
22798068	0	PCTAIRE1	52,60	Brain-selective_kinase_2	0,24	PCTAIRE1	Brain-selective kinase 2	18555(Tax:10090)	75770(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Brain-selective_kinase_2 -LRB- BRSK2 -RRB- phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic b-cells .
25205104	0	PCTAIRE1	0,8	p27	24,27	PCTAIRE1	p27	5127	10534	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells .
25593992	0	PCTAIRE1	0,8	p27	19,22	PCTAIRE1	p27	5127	10534	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|apoptosis apoptosis|amod|END_ENTITY	PCTAIRE1 regulates p27 stability , apoptosis and tumor growth in malignant_melanoma .
7656587	0	PCTK1	43,48	UBE1	95,99	PCTK1	UBE1	5127	7317	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Physical linkage of the cdc2-related gene -LRB- PCTK1 -RRB- and the ubiquitin-activating_enzyme_E1 gene -LRB- UBE1 -RRB- on human Xp11 .3 .
11891538	0	PC_3	109,113	cytochrome_P450	68,83	PC 3	cytochrome P450	57332	4051	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome_P450 activity in high passage PC_3 and DU 145 human prostate_cancer cell lines .
10760271	0	PC_cell-derived_growth_factor	14,43	PCDGF	45,50	PC cell-derived growth factor	PCDGF	2896	2896	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of PC_cell-derived_growth_factor -LRB- PCDGF , epithelin/granulin precursor -RRB- expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast_carcinoma cell line MDA-MB-468 .
24590765	0	PD-1	43,47	Blimp-1	0,7	PD-1	Blimp-1	5133	639	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral_infection .
19900372	0	PD-1	16,20	CD127	51,56	PD-1	CD127	5133	3575	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- Association of PD-1 expression on CD4 + CD25 nt/hi CD127 lo regulatory T cells with disease progression in HIV-1_infected patients -RSB- .
23324275	0	PD-1	52,56	CD4	38,41	PD-1	CD4	5133	920	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Frequency of T-cell FoxP3 Treg and CD4 / CD8 PD-1 expression is related to HBeAg seroconversion in hepatitis_B patients on pegylated interferon .
25968455	0	PD-1	46,50	CD4	23,26	PD-1	CD4	5133	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|compound|END_ENTITY	Pre-existing levels of CD4 T cells expressing PD-1 are related to overall survival in prostate_cancer patients treated with ipilimumab .
15685176	0	PD-1	72,76	CD8	42,45	PD-1	CD8	5133	925	Gene	Gene	tolerance|nmod|START_ENTITY tolerance|compound|END_ENTITY	Resting dendritic cells induce peripheral CD8 + T cell tolerance through PD-1 and CTLA-4 .
16956940	0	PD-1	0,4	CD8	91,94	PD-1	CD8	5133	925	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|exhaustion exhaustion|compound|END_ENTITY	PD-1 expression in acute hepatitis_C_virus _ -LRB- HCV -RRB- infection is associated with HCV-specific CD8 exhaustion .
18549878	0	PD-1	54,58	CD8	39,42	PD-1	CD8	5133	925	Gene	Gene	blockade|compound|START_ENTITY cells|nmod|blockade cells|compound|END_ENTITY	Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization .
18549878	0	PD-1	82,86	CD8	39,42	PD-1	CD8	5133	925	Gene	Gene	expression|compound|START_ENTITY defined|nmod|expression defined|nsubjpass|restoration restoration|nmod|cells cells|compound|END_ENTITY	Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization .
19247441	0	PD-1	84,88	CD8	50,53	PD-1	CD8	5133	925	Gene	Gene	blockade|compound|START_ENTITY exhaustion|nmod|blockade exhaustion|nsubj|reversal reversal|nmod|cell cell|compound|END_ENTITY	Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1 / CTLA-4 blockade .
19395117	0	PD-1	20,24	CD8	72,75	PD-1	CD8	5133	925	Gene	Gene	expression|compound|START_ENTITY decrease|nmod|expression correlates|nsubj|decrease correlates|nmod|development development|compound|END_ENTITY	Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis_B patients .
19595077	0	PD-1	1,5	CD8	57,60	PD-1	CD8	5133	925	Gene	Gene	up-regulation|compound|START_ENTITY influenced|nsubj|up-regulation influenced|dobj|apoptosis apoptosis|nmod|cells cells|compound|END_ENTITY	-LSB- PD-1 up-regulation influenced apoptosis of HBV-specific CD8 T cells in patients with acute resolved hepatitis_B -RSB- .
20473887	0	PD-1	0,4	CD8	37,40	PD-1	CD8	5133	925	Gene	Gene	upregulation|amod|START_ENTITY promotes|nsubj|upregulation promotes|dobj|END_ENTITY	PD-1 and PD-L1 upregulation promotes CD8 -LRB- + -RRB- T-cell apoptosis and postoperative recurrence in hepatocellular_carcinoma patients .
21070674	0	PD-1	0,4	CD8	30,33	PD-1	CD8	100037293(Tax:9823)	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|subsets subsets|compound|END_ENTITY	PD-1 expression on peripheral CD8 + TEM/TEMRA subsets closely correlated with HCV viral load in chronic_hepatitis_C patients .
22067141	0	PD-1	73,77	CD8	57,60	PD-1	CD8	5133	925	Gene	Gene	expression|compound|START_ENTITY cells|nmod|expression cells|compound|END_ENTITY	Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple_sclerosis .
22144176	0	PD-1	39,43	CD8	93,96	PD-1	CD8	5133	925	Gene	Gene	Reduced|nmod|START_ENTITY impairment|dep|Reduced impairment|acl|exhausted exhausted|dobj|cells cells|compound|END_ENTITY	Reduced tumor-antigen density leads to PD-1 / PD-L1-mediated impairment of partially exhausted CD8 T cells .
22797302	0	PD-1	69,73	CD8	48,51	PD-1	CD8	5133	925	Gene	Gene	impair|nmod|START_ENTITY impair|dobj|cells cells|nummod|END_ENTITY	Viral acute lower respiratory_infections impair CD8 + T cells through PD-1 .
23324275	0	PD-1	52,56	CD8	45,48	PD-1	CD8	5133	925	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Frequency of T-cell FoxP3 Treg and CD4 / CD8 PD-1 expression is related to HBeAg seroconversion in hepatitis_B patients on pegylated interferon .
24021877	0	PD-1	132,136	CD8	100,103	PD-1	CD8	18566(Tax:10090)	925	Gene	Gene	deletion|nmod|START_ENTITY deletion|nmod|cells cells|compound|END_ENTITY	DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1 .
24590765	0	PD-1	43,47	CD8	18,21	PD-1	CD8	5133	925	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral_infection .
24667641	0	PD-1	0,4	CD8	37,40	PD-1	CD8	5133	925	Gene	Gene	identifies|nsubj|START_ENTITY identifies|dobj|repertoire repertoire|compound|END_ENTITY	PD-1 identifies the patient-specific CD8 tumor-reactive repertoire infiltrating human tumors .
25707450	0	PD-1	12,16	CD8	70,73	PD-1	CD8	5133	925	Gene	Gene	kinase|compound|START_ENTITY Blockade|nmod|kinase enhances|nsubj|Blockade enhances|dep|T-cell T-cell|nsubj|END_ENTITY	Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8 -LRB- + -RRB- T-cell proliferation by distinct pathways .
25901287	0	PD-1	42,46	CD8	97,100	PD-1	CD8	5133	925	Gene	Gene	checkpoint|compound|START_ENTITY disrupting|dobj|checkpoint disrupting|dep|unleashing unleashing|dobj|cell cell|compound|END_ENTITY	The therapeutic promise of disrupting the PD-1 / PD-L1 immune checkpoint in cancer : unleashing the CD8 T cell mediated anti-tumor activity results in significant , unprecedented clinical efficacy in various solid tumors .
25957117	0	PD-1	0,4	CD8	82,85	PD-1	CD8	5133	925	Gene	Gene	Coexpressed|nsubjpass|START_ENTITY Coexpressed|nmod|Cells Cells|compound|END_ENTITY	PD-1 and CD103 Are Widely Coexpressed on Prognostically Favorable Intraepithelial CD8 T Cells in Human Ovarian_Cancer .
26235847	0	PD-1	47,51	CD8	56,59	PD-1	CD8	5133	925	Gene	Gene	programmed_cell_death_protein_1|appos|START_ENTITY ratio|nmod|programmed_cell_death_protein_1 ratio|parataxis|identifies identifies|nsubj|lymphocytes lymphocytes|amod|END_ENTITY	High ratio of programmed_cell_death_protein_1 -LRB- PD-1 -RRB- -LRB- + -RRB- / CD8 -LRB- + -RRB- tumor-infiltrating lymphocytes identifies a poor prognostic subset of extrahepatic_bile_duct cancer undergoing surgery plus adjuvant chemoradiotherapy .
26912627	0	PD-1	89,93	CD8	37,40	PD-1	CD8	5133	925	Gene	Gene	phenotype|compound|START_ENTITY associated|nmod|phenotype associated|nsubjpass|responses responses|nummod|END_ENTITY	Immunodominant dengue virus specific CD8 + T cells responses are associated with a memory PD-1 + phenotype .
21577144	0	PD-1	0,4	CT-011	17,23	PD-1	CT-011	100037293(Tax:9823)	884048(Tax:272561)	Gene	Gene	blockade|compound|START_ENTITY blockade|nmod|END_ENTITY	PD-1 blockade by CT-011 , anti-PD-1 antibody , enhances ex vivo T-cell responses to autologous dendritic cell/myeloma fusion vaccine .
19247441	0	PD-1	84,88	CTLA-4	89,95	PD-1	CTLA-4	5133	1493	Gene	Gene	blockade|compound|START_ENTITY blockade|compound|END_ENTITY	Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1 / CTLA-4 blockade .
25172499	0	PD-1	18,22	CXCR5	12,17	PD-1	CXCR5	5133	643	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Circulating CXCR5 + PD-1 + response predicts influenza vaccine antibody responses in young adults but not elderly adults .
25464856	0	PD-1	78,82	FoxO1	25,30	PD-1	FoxO1	5133	2308	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8 -LRB- + -RRB- T Cells during Chronic_Infection .
16265694	0	PD-1	43,47	PD-L1	49,54	PD-1	PD-L1	5133	29126	Gene	Gene	programmed_death-1|appos|START_ENTITY expression|nmod|programmed_death-1 expression|dep|END_ENTITY	Enhanced expression of programmed_death-1 -LRB- PD-1 -RRB- / PD-L1 in salivary glands of patients with Sj __ gren 's _ syndrome .
17182110	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulate regulate|nsubj|END_ENTITY	PD-1 / PD-L1 , but not PD-1 / PD-L2 , interactions regulate the severity of experimental_autoimmune_encephalomyelitis .
18287011	0	PD-1	4,8	PD-L1	9,14	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|parataxis|resembles resembles|nsubj|complex complex|compound|END_ENTITY	The PD-1 / PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors .
18296654	0	PD-1	7,11	PD-L1	0,5	PD-1	PD-L1	5133	29126	Gene	Gene	interaction|compound|START_ENTITY contributes|nsubj|interaction END_ENTITY|appos|contributes	PD-L1 : PD-1 interaction contributes to the functional suppression of T-cell responses to human uveal_melanoma cells in vitro .
18354207	0	PD-1	90,94	PD-L1	84,89	PD-1	PD-L1	5133	29126	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1 / PD-1 pathway .
18813109	0	PD-1	6,10	PD-L1	0,5	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	PD-L1 / PD-1 signal_deficiency promotes allogeneic immune responses and accelerates heart allograft rejection .
18841514	0	PD-1	44,48	PD-L1	49,54	PD-1	PD-L1	5133	29126	Gene	Gene	blockade|nmod|START_ENTITY immunotherapy|nmod|blockade pathway|dep|immunotherapy pathway|compound|END_ENTITY	Anti-tumor immunotherapy by blockade of the PD-1 / PD-L1 pathway with recombinant human PD-1-IgV .
19056397	0	PD-1	17,21	PD-L1	22,27	PD-1	PD-L1	5133	29126	Gene	Gene	Contributions|nmod|START_ENTITY Contributions|dep|END_ENTITY	Contributions of PD-1 / PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis .
19417208	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibit inhibit|nsubj|interactions interactions|compound|END_ENTITY	PD-1 / PD-L1 interactions inhibit antitumor immune responses in a murine acute_myeloid_leukemia model .
19811426	0	PD-1	13,17	PD-L1	18,23	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|parataxis|correlates correlates|nsubj|up-regulation up-regulation|compound|END_ENTITY	Intrahepatic PD-1 / PD-L1 up-regulation closely correlates with inflammation and virus replication in patients with chronic HBV_infection .
20460044	0	PD-1	66,70	PD-L1	71,76	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	blocking|dobj|START_ENTITY model|acl|blocking immunity|nmod|model Enhancement|nmod|immunity Enhancement|parataxis|signaling signaling|nsubj|END_ENTITY	-LSB- Enhancement of antiviral immunity in HBV_mouse model by blocking PD-1 / PD-L1 signaling pathway -RSB- .
20653631	0	PD-1	80,84	PD-L1	85,90	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1 / PD-L1 pathway .
21473062	0	PD-1	13,17	PD-L1	18,23	PD-1	PD-L1	5133	29126	Gene	Gene	Role|nmod|START_ENTITY Role|dep|pathway pathway|compound|END_ENTITY	-LSB- Role of the PD-1 / PD-L1 pathway in immunopathology of HBV_infection as the chance on the new therapeutic strategy -RSB- .
21645441	0	PD-1	1,5	PD-L1	6,11	PD-1	PD-L1	5133	29126	Gene	Gene	expressions|dep|START_ENTITY expressions|compound|END_ENTITY	-LSB- PD-1 / PD-L1 expressions in liver tissues of patients with chronic HBV_infection -RSB- .
21659460	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|appos|contribute contribute|nsubj|interactions interactions|compound|END_ENTITY	PD-1 / PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation .
21912640	0	PD-1	34,38	PD-L1	28,33	PD-1	PD-L1	5133	29126	Gene	Gene	associated|nsubjpass|START_ENTITY Upregulation|parataxis|associated Upregulation|acl|circulating circulating|dobj|END_ENTITY	Upregulation of circulating PD-L1 / PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related_hepatocellular_carcinoma .
21960736	0	PD-1	4,8	PD-L1	9,14	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|parataxis|pathway pathway|nsubj|END_ENTITY	The PD-1 / PD-L1 -LRB- B7-H1 -RRB- pathway in chronic_infection-induced cytotoxic T lymphocyte exhaustion .
22023178	0	PD-1	99,103	PD-L1	104,109	PD-1	PD-L1	5133	29126	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Therapeutic intervention in cancer_and_chronic_viral_infections : antibody mediated manipulation of PD-1 / PD-L1 interaction .
22169317	0	PD-1	20,24	PD-L1	25,30	PD-1	PD-L1	5133	29126	Gene	Gene	update|nmod|START_ENTITY update|dep|pathway pathway|compound|END_ENTITY	-LSB- Research update on PD-1 / PD-L1 pathway in hematological_diseases -RSB- .
22588271	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|appos|enhance enhance|nsubj|blockade blockade|compound|END_ENTITY	PD-1 / PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines .
23243584	0	PD-1	10,14	PD-L1	15,20	PD-1	PD-L1	5133	29126	Gene	Gene	interactions|dep|START_ENTITY interactions|compound|END_ENTITY	Targeting PD-1 / PD-L1 interactions for cancer immunotherapy .
23288508	0	PD-1	27,31	PD-L1	32,37	PD-1	PD-L1	5133	29126	Gene	Gene	role|nmod|START_ENTITY Evidence|nmod|role Evidence|dep|pathway pathway|compound|END_ENTITY	Evidence for a role of the PD-1 : PD-L1 pathway in immune resistance of HPV-associated head_and_neck_squamous_cell_carcinoma .
23523609	0	PD-1	12,16	PD-L1	17,22	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	checkpoint|compound|START_ENTITY checkpoint|compound|END_ENTITY	Blockade of PD-1 / PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast_cancer in hu-SCID mice .
23624877	0	PD-1	17,21	PD-L1	22,27	PD-1	PD-L1	5133	29126	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|compound|END_ENTITY	Critical role of PD-1 / PD-L1 pathway in generation and function of follicular regulatory T cells .
23792703	0	PD-1	37,41	PD-L1	42,47	PD-1	PD-L1	5133	29126	Gene	Gene	role|nmod|START_ENTITY insights|nmod|role insights|dep|pathway pathway|compound|END_ENTITY	Recent insights into the role of the PD-1 / PD-L1 pathway in immunological tolerance and autoimmunity .
23977133	0	PD-1	16,20	PD-L1	10,15	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	coinhibition|compound|START_ENTITY regulates|nsubj|coinhibition END_ENTITY|parataxis|regulates	A missing PD-L1 / PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner .
24015822	0	PD-1	106,110	PD-L1	0,5	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	opposition|nmod|START_ENTITY mice|nmod|opposition stroke|nmod|mice inflammation|nmod|stroke enhances|dobj|inflammation enhances|nsubj|END_ENTITY	PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1 .
24065812	0	PD-1	72,76	PD-L1	66,71	PD-1	PD-L1	5133	29126	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Suppression of IL-22-producing T helper 22 cells by RPE cells via PD-L1 / PD-1 interactions .
24401835	0	PD-1	24,28	PD-L1	18,23	PD-1	PD-L1	5133	29126	Gene	Gene	co-stimulation|compound|START_ENTITY enhances|nsubj|co-stimulation Interference|parataxis|enhances Interference|nmod|END_ENTITY	Interference with PD-L1 / PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells .
24506960	0	PD-1	15,19	PD-L1	20,25	PD-1	PD-L1	5133	29126	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	-LSB- Expression of PD-1 / PD-L1 in peripheral blood mononuclear cells in lung_cancer patients and its biological significance -RSB- .
24626392	0	PD-1	68,72	PD-L1	62,67	PD-1	PD-L1	100037293(Tax:9823)	29126	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Immune suppression by neutrophils in HIV-1_infection : role of PD-L1 / PD-1 pathway .
25047812	0	PD-1	25,29	PD-L1	82,87	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	death|appos|START_ENTITY regulates|nsubj|death regulates|dobj|function function|nmod|cells cells|nmod|END_ENTITY	Programmed cell death 1 -LRB- PD-1 -RRB- regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes .
25248890	0	PD-1	15,19	PD-L1	20,25	PD-1	PD-L1	5133	29126	Gene	Gene	Targeting|dep|START_ENTITY Targeting|parataxis|END_ENTITY	-LSB- Targeting the PD-1 / PD-L1 immune checkpoint signal - a new treatment strategy for cancer -RSB- .
25342040	0	PD-1	13,17	PD-L1	18,23	PD-1	PD-L1	5133	29126	Gene	Gene	Advances|nmod|START_ENTITY Advances|dep|Pathway Pathway|compound|END_ENTITY	-LSB- Advances of PD-1 / PD-L1 Signaling Pathway in Immune Escape and Treatment for Non-small_Cell_Lung_Cancer -RSB- .
25349132	0	PD-1	0,4	PD-L1	6,11	PD-1	PD-L1	5133	29126	Gene	Gene	PD-L2|amod|START_ENTITY PD-L2|amod|END_ENTITY	PD-1 , PD-L1 , PD-L2 expression in the chordoma microenvironment .
25392179	0	PD-1	25,29	PD-L1	47,52	PD-1	PD-L1	5133	29126	Gene	Gene	Programmed_Cell_Death_1|appos|START_ENTITY END_ENTITY|nsubj|Programmed_Cell_Death_1	Programmed_Cell_Death_1 -LRB- PD-1 -RRB- and Its Ligand -LRB- PD-L1 -RRB- in Common Cancers and Their Correlation with Molecular Cancer Type .
25415283	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|dep|Blockade Blockade|compound|END_ENTITY	PD-1 / PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic_Tumors .
25433812	0	PD-1	88,92	PD-L1	93,98	PD-1	PD-L1	5133	29126	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1 / PD-L1 interactions .
25491730	0	PD-1	4,8	PD-L1	9,14	PD-1	PD-L1	5133	29126	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The PD-1 / PD-L1 pathway : biological background and clinical relevance of an emerging treatment target in immunotherapy .
25630305	0	PD-1	53,57	PD-L1	58,63	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	subsets|nmod|START_ENTITY subsets|dep|axis axis|compound|END_ENTITY	Differential control of CD4 -LRB- + -RRB- T-cell subsets by the PD-1 / PD-L1 axis in a mouse model of allergic_asthma .
25640631	0	PD-1	36,40	PD-L1	41,46	PD-1	PD-L1	100037293(Tax:9823)	574058(Tax:9823)	Gene	Gene	Insight|nmod|START_ENTITY Insight|dep|Pathway Pathway|compound|END_ENTITY	Recent Insight into the Role of the PD-1 / PD-L1 Pathway in Feto-Maternal Tolerance and Pregnancy .
25645798	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	START_ENTITY|dep|Tolerance Tolerance|compound|END_ENTITY	PD-1 / PD-L1 Costimulatory Pathway-induced Mouse Islet Transplantation Immune Tolerance .
25674748	0	PD-1	52,56	PD-L1	76,81	PD-1	PD-L1	5133	29126	Gene	Gene	Programmed_Cell_Death_1|appos|START_ENTITY Programmed_Cell_Death_1|appos|END_ENTITY	Prognostic Significance of Programmed_Cell_Death_1 -LRB- PD-1 -RRB- or PD-1_Ligand_1 -LRB- PD-L1 -RRB- Expression in Epithelial-Originated Cancer : A Meta-Analysis .
25691326	0	PD-1	83,87	PD-L1	88,93	PD-1	PD-L1	5133	29126	Gene	Gene	Synergizes|nmod|START_ENTITY Blockade|nmod|Synergizes Blockade|compound|END_ENTITY	Virotherapy with a Semliki_Forest_Virus-Based Vector Encoding IL12 Synergizes with PD-1 / PD-L1 Blockade .
25778100	0	PD-1	6,10	PD-L1	0,5	PD-1	PD-L1	5133	29126	Gene	Gene	presence|compound|START_ENTITY END_ENTITY|dep|presence	PD-L1 / PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma .
25778100	0	PD-1	66,70	PD-L1	0,5	PD-1	PD-L1	5133	29126	Gene	Gene	blockade|compound|START_ENTITY microenvironment|nmod|blockade presence|nmod|microenvironment END_ENTITY|dep|presence	PD-L1 / PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma .
25823918	0	PD-1	39,43	PD-L1	44,49	PD-1	PD-L1	5133	29126	Gene	Gene	Inhibitors|dep|START_ENTITY Inhibitors|dep|Blockade Blockade|compound|END_ENTITY	The Next Immune-Checkpoint Inhibitors : PD-1 / PD-L1 Blockade in Melanoma .
25901287	0	PD-1	42,46	PD-L1	47,52	PD-1	PD-L1	5133	29126	Gene	Gene	checkpoint|compound|START_ENTITY checkpoint|compound|END_ENTITY	The therapeutic promise of disrupting the PD-1 / PD-L1 immune checkpoint in cancer : unleashing the CD8 T cell mediated anti-tumor activity results in significant , unprecedented clinical efficacy in various solid tumors .
25914862	0	PD-1	30,34	PD-L1	127,132	PD-1	PD-L1	100037293(Tax:9823)	574058(Tax:9823)	Gene	Gene	Unleashing|dep|START_ENTITY Unleashing|parataxis|blockade blockade|compound|END_ENTITY	Unleashing the immune system : PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1 / PD-L1 blockade .
25919090	0	PD-1	14,18	PD-L1	19,24	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	Targeting|dobj|START_ENTITY Axis|dep|Targeting Axis|compound|END_ENTITY	Targeting the PD-1 / PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers .
25919090	0	PD-1	14,18	PD-L1	19,24	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	Targeting|dobj|START_ENTITY Axis|dep|Targeting Axis|compound|END_ENTITY	Targeting the PD-1 / PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers .
25944714	0	PD-1	10,14	PD-L1	15,20	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|Associated Associated|nsubj|Expression Expression|compound|END_ENTITY	Decreased PD-1 / PD-L1 Expression Is Associated with the Reduction in Mucosal Immunoglobulin A in Mice with Intestinal_Ischemia Reperfusion .
25944714	0	PD-1	10,14	PD-L1	15,20	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|Associated Associated|nsubj|Expression Expression|compound|END_ENTITY	Decreased PD-1 / PD-L1 Expression Is Associated with the Reduction in Mucosal Immunoglobulin A in Mice with Intestinal_Ischemia Reperfusion .
26005519	0	PD-1	18,22	PD-L1	23,28	PD-1	PD-L1	5133	29126	Gene	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|parataxis|Mobilize Mobilize|nsubj|Pathway Pathway|compound|END_ENTITY	Inhibitors of the PD-1 / PD-L1 Pathway Can Mobilize the Immune System : An Innovative Potential Therapy for Cancer and Chronic_Infections .
26047524	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|appos|inhibitors inhibitors|nsubj|END_ENTITY	PD-1 / PD-L1 inhibitors .
26091678	0	PD-1	61,65	PD-L1	66,71	PD-1	PD-L1	5133	29126	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	Hematologic_Cancers Break Down a ` Checkpoint ' : Targeting the PD-1 / PD-L1 Axis .
26259671	0	PD-1	16,20	PD-L1	21,26	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	Blocking|nmod|START_ENTITY Blocking|dep|Interaction Interaction|compound|END_ENTITY	Blocking of the PD-1 / PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy .
26279307	0	PD-1	15,19	PD-L1	20,25	PD-1	PD-L1	5133	29126	Gene	Gene	Development|nmod|START_ENTITY Development|dep|Pathway Pathway|compound|END_ENTITY	Development of PD-1 / PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small_Cell_Lung_Cancer .
26279307	0	PD-1	15,19	PD-L1	20,25	PD-1	PD-L1	5133	29126	Gene	Gene	Development|nmod|START_ENTITY Development|dep|Pathway Pathway|compound|END_ENTITY	Development of PD-1 / PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small_Cell_Lung_Cancer .
26286967	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|appos|participates participates|nsubj|signal signal|compound|END_ENTITY	PD-1 / PD-L1 signal pathway participates in HCV F protein-induced T cell dysfunction in chronic HCV_infection .
26346135	0	PD-1	37,41	PD-L1	42,47	PD-1	PD-L1	5133	29126	Gene	Gene	therapies|nmod|START_ENTITY blockade|nmod|therapies blockade|compound|END_ENTITY	Efficacy of targeted therapies after PD-1 / PD-L1 blockade in metastatic renal_cell_carcinoma .
26346135	0	PD-1	37,41	PD-L1	42,47	PD-1	PD-L1	5133	29126	Gene	Gene	therapies|nmod|START_ENTITY blockade|nmod|therapies blockade|compound|END_ENTITY	Efficacy of targeted therapies after PD-1 / PD-L1 blockade in metastatic renal_cell_carcinoma .
26373277	0	PD-1	67,71	PD-L1	72,77	PD-1	PD-L1	5133	29126	Gene	Gene	Axis|dep|START_ENTITY Axis|compound|END_ENTITY	FcyRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1 / PD-L1 Axis .
26446939	0	PD-1	167,171	PD-L1	161,166	PD-1	PD-L1	5133	574058(Tax:9823)	Gene	Gene	axis|compound|START_ENTITY associated|nsubjpass|axis END_ENTITY|parataxis|associated	The PD-L1 / CD86 ratio is increased in dendritic cells co-infected with porcine_circovirus_type_2 and porcine_reproductive_and_respiratory_syndrome_virus , and the PD-L1 / PD-1 axis is associated with anergy , apoptosis , and the induction of regulatory T-cells in porcine lymphocytes .
26446939	0	PD-1	167,171	PD-L1	4,9	PD-1	PD-L1	5133	29126	Gene	Gene	axis|compound|START_ENTITY associated|nsubjpass|axis PD-L1|parataxis|associated END_ENTITY|dep|PD-L1	The PD-L1 / CD86 ratio is increased in dendritic cells co-infected with porcine_circovirus_type_2 and porcine_reproductive_and_respiratory_syndrome_virus , and the PD-L1 / PD-1 axis is associated with anergy , apoptosis , and the induction of regulatory T-cells in porcine lymphocytes .
26448693	0	PD-1	32,36	PD-L1	37,42	PD-1	PD-L1	5133	29126	Gene	Gene	Blockade|compound|START_ENTITY Blockade|compound|END_ENTITY	Human Cancer Immunotherapy with PD-1 / PD-L1 Blockade .
26515496	0	PD-1	152,156	PD-L1	157,162	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast_Cancer : Therapeutic Cooperation Between MEK and PD-1 / PD-L1 Immune Checkpoint Inhibitors .
26559787	0	PD-1	32,36	PD-L1	37,42	PD-1	PD-L1	5133	29126	Gene	Gene	assays|nmod|START_ENTITY assays|dep|inhibitors inhibitors|compound|END_ENTITY	Companion diagnostic assays for PD-1 / PD-L1 checkpoint inhibitors in NSCLC .
26582228	0	PD-1	36,40	PD-L1	41,46	PD-1	PD-L1	5133	29126	Gene	Gene	Progress|nmod|START_ENTITY Progress|dep|Antibody Antibody|compound|END_ENTITY	-LSB- Clinical Research Progress of Anti PD-1 / PD-L1 Monoclonal Antibody in the Treatment of Lung_Cancer -RSB- .
26589760	0	PD-1	25,29	PD-L1	30,35	PD-1	PD-L1	5133	29126	Gene	Gene	immunotherapy|compound|START_ENTITY immunotherapy|compound|END_ENTITY	Predictive biomarkers in PD-1 / PD-L1 checkpoint blockade immunotherapy .
26619015	0	PD-1	36,40	PD-L1	41,46	PD-1	PD-L1	5133	29126	Gene	Gene	Challenges|nmod|START_ENTITY Challenges|dep|Inhibitors Inhibitors|compound|END_ENTITY	Challenges to Biomarker Testing for PD-1 / PD-L1 Checkpoint Inhibitors for Lung_Cancer .
26859684	0	PD-1	18,22	PD-L1	23,28	PD-1	PD-L1	5133	29126	Gene	Gene	checkpoint|compound|START_ENTITY checkpoint|compound|END_ENTITY	Activation of the PD-1 / PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis .
26871284	0	PD-1	30,34	PD-L1	24,29	PD-1	PD-L1	5133	29126	Gene	Gene	blockade|compound|START_ENTITY Implication|dep|blockade Implication|nmod|END_ENTITY	Implication of combined PD-L1 / PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal_cancer .
26895815	0	PD-1	51,55	PD-L1	0,5	PD-1	PD-L1	5133	29126	Gene	Gene	antibodies|compound|START_ENTITY receiving|dobj|antibodies patients|acl|receiving expression|nmod|patients expression|compound|END_ENTITY	PD-L1 expression in cancer patients receiving anti PD-1 / PD-L1 antibodies : A systematic review and meta-analysis .
26895815	0	PD-1	51,55	PD-L1	56,61	PD-1	PD-L1	5133	29126	Gene	Gene	antibodies|compound|START_ENTITY antibodies|compound|END_ENTITY	PD-L1 expression in cancer patients receiving anti PD-1 / PD-L1 antibodies : A systematic review and meta-analysis .
26899259	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|dep|blockade blockade|compound|END_ENTITY	PD-1 / PD-L1 blockade in cancer treatment : perspectives and issues .
26968586	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|appos|blockage blockage|nsubj|END_ENTITY	PD-1 / PD-L1 blockage in cancer treatment-from basic research to clinical application .
27057446	0	PD-1	9,13	PD-L1	14,19	PD-1	PD-L1	18566(Tax:10090)	60533(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|administration administration|compound|END_ENTITY	Repeated PD-1 / PD-L1 monoclonal antibody administration induces fatal xenogeneic_hypersensitivity_reactions in a murine model of breast_cancer .
27058572	0	PD-1	0,4	PD-L1	5,10	PD-1	PD-L1	5133	29126	Gene	Gene	START_ENTITY|dep|blockade blockade|amod|immune immune|amod|END_ENTITY	PD-1 / PD-L1 immune checkpoint blockade in non-small_cell_lung_cancer .
7851902	0	PD-1	52,56	PDCD1	63,68	PD-1	PDCD1	5133	5133	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and chromosomal localization of the human PD-1 gene -LRB- PDCD1 -RRB- .
25027060	0	PD-1	32,36	Programmed_Death-1	12,30	PD-1	Programmed Death-1	18566(Tax:10090)	18566(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Role of the Programmed_Death-1 -LRB- PD-1 -RRB- pathway in regulation of Theiler 's murine encephalomyelitis virus-induced demyelinating_disease .
26221374	0	PD-1	20,24	Programmed_death-1	0,18	PD-1	Programmed death-1	5133	5133	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Programmed_death-1 -LRB- PD-1 -RRB- polymorphism is associated with gastric_cardia_adenocarcinoma .
26221374	0	PD-1	20,24	Programmed_death-1	0,18	PD-1	Programmed death-1	5133	5133	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Programmed_death-1 -LRB- PD-1 -RRB- polymorphism is associated with gastric_cardia_adenocarcinoma .
26885204	0	PD-1	20,24	Programmed_death-1	0,18	PD-1	Programmed death-1	5133	5133	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Programmed_death-1 -LRB- PD-1 -RRB- rs2227981 C > T polymorphism is associated with cancer susceptibility : a meta-analysis .
21623380	0	PD-1	75,79	T-bet	21,26	PD-1	T-bet	5133	30009	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8 + T cell responses during chronic_infection .
18828017	0	PD-1	57,61	arginase_I	14,24	PD-1	arginase I	18566(Tax:10090)	11846(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of arginase_I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells .
23966393	0	PD-1	47,51	interleukin-6	12,25	PD-1	interleukin-6	18566(Tax:10090)	16193(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of interleukin-6 in the expression of PD-1 and PDL-1 on central nervous system cells following infection with Theiler 's murine encephalomyelitis virus .
12847138	0	PD-1	41,45	programmed_death-1	21,39	PD-1	programmed death-1	18566(Tax:10090)	18566(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Critical role of the programmed_death-1 -LRB- PD-1 -RRB- pathway in regulation of experimental autoimmune encephalomyelitis .
9920107	0	PD-ECGF	63,70	platelet-derived_endothelial_cell_growth_factor	14,61	PD-ECGF	platelet-derived endothelial cell growth factor	1890	1890	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of platelet-derived_endothelial_cell_growth_factor -LRB- PD-ECGF -RRB- related to angiogenesis in ovarian_endometriosis .
21268011	0	PD-L1	0,5	APCs	32,36	PD-L1	APCs	29126	325	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	PD-L1 expression on tolerogenic APCs is controlled by STAT-3 .
16797416	0	PD-L1	36,41	B7-H1	29,34	PD-L1	B7-H1	29126	29126	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of leukemia-derived B7-H1 -LRB- PD-L1 -RRB- in tumor-T-cell interactions in humans .
17186290	0	PD-L1	25,30	B7-H1	18,23	PD-L1	B7-H1	29126	29126	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of B7-H1 -LRB- PD-L1 -RRB- significantly associates with tumor grade and postoperative prognosis in human urothelial_cancers .
17340590	0	PD-L1	0,5	B7-H1	7,12	PD-L1	B7-H1	29126	29126	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	PD-L1 -LRB- B7-H1 -RRB- expression by urothelial_carcinoma of the bladder and BCG-induced granulomata : associations with localized stage progression .
23656736	0	PD-L1	0,5	B7-H1	6,11	PD-L1	B7-H1	574058(Tax:9823)	60533(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	PD-L1 / B7-H1 regulates the survival but not the function of CD8 + T cells in herpes_simplex_virus_type_1 latently infected trigeminal ganglia .
24696476	0	PD-L1	26,31	B7-H1	33,38	PD-L1	B7-H1	60533(Tax:10090)	60533(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	HIV-1 Tat protein induces PD-L1 _ -LRB- B7-H1 -RRB- expression on dendritic cells through tumor_necrosis_factor_alpha - and toll-like_receptor_4-mediated mechanisms .
26527522	0	PD-L1	0,5	B7-H1	7,12	PD-L1	B7-H1	29126	29126	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	PD-L1 -LRB- B7-H1 -RRB- expression and the immune tumor microenvironment in primary and metastatic breast_carcinomas .
25361854	0	PD-L1	31,36	CD14	37,41	PD-L1	CD14	29126	929	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	High and interrelated rates of PD-L1 + CD14 + antigen-presenting cells and regulatory T cells mark the microenvironment of metastatic lymph nodes from patients with cervical_cancer .
19229109	0	PD-L1	0,5	CD25	31,35	PD-L1	CD25	29126	3559	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|Tregs Tregs|compound|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
26166019	0	PD-L1	27,32	CD25	40,44	PD-L1	CD25	29126	3559	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26266813	0	PD-L1	14,19	CD25	27,31	PD-L1	CD25	29126	3559	Gene	Gene	START_ENTITY|nmod|Foxp3 Foxp3|compound|END_ENTITY	Expression of PD-L1 on CD4 + CD25 + Foxp3 + Regulatory T Cells of Patients with Chronic_HBV_Infection and Its Correlation with Clinical Parameters .
25697485	0	PD-L1	26,31	CD274	33,38	PD-L1	CD274	29126	29126	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TLR3 triggering regulates PD-L1 -LRB- CD274 -RRB- expression in human neuroblastoma cells .
17924994	0	PD-L1	22,27	CD4	74,77	PD-L1	CD4	29126	920	Gene	Gene	pathways|compound|START_ENTITY dichotomy|nmod|pathways dichotomy|acl|regulating regulating|xcomp|cells cells|nsubj|END_ENTITY	Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells in vivo .
19229109	0	PD-L1	0,5	CD4	27,30	PD-L1	CD4	29126	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|Tregs Tregs|nummod|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
22322668	0	PD-L1	118,123	CD4	79,82	PD-L1	CD4	29126	920	Gene	Gene	Foxp3|dep|START_ENTITY Foxp3|amod|functional functional|dep|END_ENTITY	Immune suppression in premalignant respiratory_papillomas : enriched functional CD4 + Foxp3 + regulatory T cells and PD-1 / PD-L1 / L2 expression .
23734334	0	PD-L1	32,37	CD4	83,86	PD-L1	CD4	29126	920	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4 -LRB- + -RRB- T cells .
25630305	0	PD-L1	58,63	CD4	24,27	PD-L1	CD4	60533(Tax:10090)	12504(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY subsets|dep|axis subsets|nsubj|control control|nmod|T-cell T-cell|compound|END_ENTITY	Differential control of CD4 -LRB- + -RRB- T-cell subsets by the PD-1 / PD-L1 axis in a mouse model of allergic_asthma .
26116499	0	PD-L1	68,73	CD4	0,3	PD-L1	CD4	29126	920	Gene	Gene	Blockade|compound|START_ENTITY Potential|nmod|Blockade Augments|dobj|Potential Augments|nsubj|Substantially Substantially|compound|END_ENTITY	CD4 T Cell Depletion Substantially Augments the Rescue Potential of PD-L1 Blockade for Deeply Exhausted CD8 T Cells .
26166019	0	PD-L1	27,32	CD4	36,39	PD-L1	CD4	29126	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
26266813	0	PD-L1	14,19	CD4	23,26	PD-L1	CD4	29126	920	Gene	Gene	START_ENTITY|nmod|Foxp3 Foxp3|compound|END_ENTITY	Expression of PD-L1 on CD4 + CD25 + Foxp3 + Regulatory T Cells of Patients with Chronic_HBV_Infection and Its Correlation with Clinical Parameters .
26615520	0	PD-L1	121,126	CD4	76,79	PD-L1	CD4	29126	920	Gene	Gene	cells|dep|START_ENTITY activation|nmod|cells activation|nmod|CD25 CD25|compound|END_ENTITY	Human umbilical vein endothelial cells promote the inhibitory activation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via PD-L1 .
25901287	0	PD-L1	47,52	CD8	97,100	PD-L1	CD8	29126	925	Gene	Gene	checkpoint|compound|START_ENTITY disrupting|dobj|checkpoint disrupting|dep|unleashing unleashing|dobj|cell cell|compound|END_ENTITY	The therapeutic promise of disrupting the PD-1 / PD-L1 immune checkpoint in cancer : unleashing the CD8 T cell mediated anti-tumor activity results in significant , unprecedented clinical efficacy in various solid tumors .
25009014	0	PD-L1	15,20	EGFR	52,56	PD-L1	EGFR	29126	1956	Gene	Gene	overexpression|compound|START_ENTITY overexpression|acl|activating activating|dobj|mutations mutations|amod|END_ENTITY	Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell_lung_cancer .
25592115	0	PD-L1	5,10	EGFR	71,75	PD-L1	EGFR	574058(Tax:9823)	397070(Tax:9823)	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|mutation mutation|amod|END_ENTITY	PD-1 / PD-L1 pathway in non-small-cell_lung_cancer and its relation with EGFR mutation .
25658629	0	PD-L1	16,21	EGFR	163,167	PD-L1	EGFR	29126	1956	Gene	Gene	Upregulation|nmod|START_ENTITY Mediates|nsubj|Upregulation Mediates|nmod|Mutation Mutation|compound|END_ENTITY	Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC : Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation .
25658629	0	PD-L1	16,21	EGFR	25,29	PD-L1	EGFR	29126	1956	Gene	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC : Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation .
25998384	0	PD-L1	24,29	EGFR	33,37	PD-L1	EGFR	29126	1956	Gene	Gene	START_ENTITY|nmod|NSCLC NSCLC|compound|END_ENTITY	EGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-kB .
26175921	0	PD-L1	0,5	EGFR	52,56	PD-L1	EGFR	29126	1956	Gene	Gene	expression|compound|START_ENTITY associated|nsubj|expression associated|nmod|response response|nmod|inhibitors inhibitors|amod|END_ENTITY	PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors .
26676749	0	PD-L1	100,105	EGFR	74,78	PD-L1	EGFR	29126	1956	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression downstream|acl:relcl|induce downstream|nmod|END_ENTITY	Identification of the cell-intrinsic and extrinsic pathways downstream of EGFR and IFNy that induce PD-L1 expression in head_and_neck_cancer .
26898608	0	PD-L1	0,5	EGFR	119,123	PD-L1	EGFR	29126	1956	Gene	Gene	lymphocytes|amod|START_ENTITY prognostic|nsubj|lymphocytes prognostic|nmod|patients patients|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|acl|treated treated|nmod|inhibitors inhibitors|amod|END_ENTITY	PD-L1 on peripheral blood T lymphocytes is prognostic in patients with non-small_cell_lung_cancer -LRB- NSCLC -RRB- treated with EGFR inhibitors .
26166019	0	PD-L1	27,32	FOXP3	45,50	PD-L1	FOXP3	29126	50943	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression of coinhibitory PD-L1 on CD4 + CD25 + FOXP3 + regulatory T cells is elevated in patients with acute_coronary_syndrome .
19229109	0	PD-L1	0,5	Foxp3	36,41	PD-L1	Foxp3	29126	50943	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|Tregs Tregs|compound|END_ENTITY	PD-L1 negatively regulates CD4 + CD25 + Foxp3 + Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV .
23769057	0	PD-L1	0,5	Foxp3	54,59	PD-L1	Foxp3	60533(Tax:10090)	20371(Tax:10090)	Gene	Gene	signal|compound|START_ENTITY critical|nsubj|signal critical|nmod|END_ENTITY	PD-L1 signal on liver dendritic cells is critical for Foxp3 -LRB- + -RRB- CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Treg and liver tolerance induction in mice .
26615520	0	PD-L1	121,126	Foxp3	89,94	PD-L1	Foxp3	29126	50943	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Human umbilical vein endothelial cells promote the inhibitory activation of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via PD-L1 .
26775640	0	PD-L1	45,50	HDAC6	18,23	PD-L1	HDAC6	574058(Tax:9823)	100621798	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Essential role of HDAC6 in the regulation of PD-L1 in melanoma .
24778419	0	PD-L1	0,5	HIF-1a	34,40	PD-L1	HIF-1a	60533(Tax:10090)	15251(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	PD-L1 is a novel direct target of HIF-1a , and its blockade under hypoxia enhanced MDSC-mediated T cell activation .
26927379	0	PD-L1	20,25	IFN-y	1,6	PD-L1	IFN-y	29126	3458	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- IFN-y up-regulates PD-L1 expression in human placenta mesenchymal stem cells and enhances cell ability to induce the differentiation of IL-10 -LRB- + -RRB- T cells from cord blood - and peripheral blood-derived T cells -RSB- .
16265694	0	PD-L1	49,54	PD-1	43,47	PD-L1	PD-1	29126	5133	Gene	Gene	expression|dep|START_ENTITY expression|nmod|programmed_death-1 programmed_death-1|appos|END_ENTITY	Enhanced expression of programmed_death-1 -LRB- PD-1 -RRB- / PD-L1 in salivary glands of patients with Sj __ gren 's _ syndrome .
17182110	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY END_ENTITY|appos|regulate	PD-1 / PD-L1 , but not PD-1 / PD-L2 , interactions regulate the severity of experimental_autoimmune_encephalomyelitis .
18287011	0	PD-L1	9,14	PD-1	4,8	PD-L1	PD-1	29126	5133	Gene	Gene	complex|compound|START_ENTITY resembles|nsubj|complex END_ENTITY|parataxis|resembles	The PD-1 / PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors .
18296654	0	PD-L1	0,5	PD-1	7,11	PD-L1	PD-1	29126	5133	Gene	Gene	START_ENTITY|appos|contributes contributes|nsubj|interaction interaction|compound|END_ENTITY	PD-L1 : PD-1 interaction contributes to the functional suppression of T-cell responses to human uveal_melanoma cells in vitro .
18354207	0	PD-L1	84,89	PD-1	90,94	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1 / PD-1 pathway .
18813109	0	PD-L1	0,5	PD-1	6,10	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	PD-L1 / PD-1 signal_deficiency promotes allogeneic immune responses and accelerates heart allograft rejection .
18841514	0	PD-L1	49,54	PD-1	44,48	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|immunotherapy immunotherapy|nmod|blockade blockade|nmod|END_ENTITY	Anti-tumor immunotherapy by blockade of the PD-1 / PD-L1 pathway with recombinant human PD-1-IgV .
19056397	0	PD-L1	22,27	PD-1	17,21	PD-L1	PD-1	29126	5133	Gene	Gene	Contributions|dep|START_ENTITY Contributions|nmod|END_ENTITY	Contributions of PD-1 / PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosis .
19417208	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY inhibit|nsubj|interactions END_ENTITY|appos|inhibit	PD-1 / PD-L1 interactions inhibit antitumor immune responses in a murine acute_myeloid_leukemia model .
19811426	0	PD-L1	18,23	PD-1	13,17	PD-L1	PD-1	29126	5133	Gene	Gene	up-regulation|compound|START_ENTITY correlates|nsubj|up-regulation END_ENTITY|parataxis|correlates	Intrahepatic PD-1 / PD-L1 up-regulation closely correlates with inflammation and virus replication in patients with chronic HBV_infection .
20460044	0	PD-L1	71,76	PD-1	66,70	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY Enhancement|parataxis|signaling Enhancement|nmod|immunity immunity|nmod|model model|acl|blocking blocking|dobj|END_ENTITY	-LSB- Enhancement of antiviral immunity in HBV_mouse model by blocking PD-1 / PD-L1 signaling pathway -RSB- .
20653631	0	PD-L1	85,90	PD-1	80,84	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1 / PD-L1 pathway .
21473062	0	PD-L1	18,23	PD-1	13,17	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY Role|dep|pathway Role|nmod|END_ENTITY	-LSB- Role of the PD-1 / PD-L1 pathway in immunopathology of HBV_infection as the chance on the new therapeutic strategy -RSB- .
21645441	0	PD-L1	6,11	PD-1	1,5	PD-L1	PD-1	29126	5133	Gene	Gene	expressions|compound|START_ENTITY expressions|dep|END_ENTITY	-LSB- PD-1 / PD-L1 expressions in liver tissues of patients with chronic HBV_infection -RSB- .
21659460	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	interactions|compound|START_ENTITY contribute|nsubj|interactions END_ENTITY|appos|contribute	PD-1 / PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation .
21912640	0	PD-L1	28,33	PD-1	34,38	PD-L1	PD-1	29126	5133	Gene	Gene	circulating|dobj|START_ENTITY Upregulation|acl|circulating Upregulation|parataxis|associated associated|nsubjpass|END_ENTITY	Upregulation of circulating PD-L1 / PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related_hepatocellular_carcinoma .
21960736	0	PD-L1	9,14	PD-1	4,8	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|nsubj|START_ENTITY END_ENTITY|parataxis|pathway	The PD-1 / PD-L1 -LRB- B7-H1 -RRB- pathway in chronic_infection-induced cytotoxic T lymphocyte exhaustion .
22023178	0	PD-L1	104,109	PD-1	99,103	PD-L1	PD-1	29126	5133	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Therapeutic intervention in cancer_and_chronic_viral_infections : antibody mediated manipulation of PD-1 / PD-L1 interaction .
22169317	0	PD-L1	25,30	PD-1	20,24	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY update|dep|pathway update|nmod|END_ENTITY	-LSB- Research update on PD-1 / PD-L1 pathway in hematological_diseases -RSB- .
22588271	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	blockade|compound|START_ENTITY enhance|nsubj|blockade END_ENTITY|appos|enhance	PD-1 / PD-L1 blockade can enhance HIV-1 Gag-specific T cell immunity elicited by dendritic cell-directed lentiviral vaccines .
23243584	0	PD-L1	15,20	PD-1	10,14	PD-L1	PD-1	29126	5133	Gene	Gene	interactions|compound|START_ENTITY interactions|dep|END_ENTITY	Targeting PD-1 / PD-L1 interactions for cancer immunotherapy .
23288508	0	PD-L1	32,37	PD-1	27,31	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY Evidence|dep|pathway Evidence|nmod|role role|nmod|END_ENTITY	Evidence for a role of the PD-1 : PD-L1 pathway in immune resistance of HPV-associated head_and_neck_squamous_cell_carcinoma .
23523609	0	PD-L1	17,22	PD-1	12,16	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	checkpoint|compound|START_ENTITY checkpoint|compound|END_ENTITY	Blockade of PD-1 / PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast_cancer in hu-SCID mice .
23624877	0	PD-L1	22,27	PD-1	17,21	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	Critical role of PD-1 / PD-L1 pathway in generation and function of follicular regulatory T cells .
23792703	0	PD-L1	42,47	PD-1	37,41	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY insights|dep|pathway insights|nmod|role role|nmod|END_ENTITY	Recent insights into the role of the PD-1 / PD-L1 pathway in immunological tolerance and autoimmunity .
23977133	0	PD-L1	10,15	PD-1	16,20	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|coinhibition coinhibition|compound|END_ENTITY	A missing PD-L1 / PD-1 coinhibition regulates diabetes induction by preproinsulin-specific CD8 T-cells in an epitope-specific manner .
24015822	0	PD-L1	0,5	PD-1	106,110	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|inflammation inflammation|nmod|stroke stroke|nmod|mice mice|nmod|opposition opposition|nmod|END_ENTITY	PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1 .
24065812	0	PD-L1	66,71	PD-1	72,76	PD-L1	PD-1	29126	5133	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Suppression of IL-22-producing T helper 22 cells by RPE cells via PD-L1 / PD-1 interactions .
24401835	0	PD-L1	18,23	PD-1	24,28	PD-L1	PD-1	29126	5133	Gene	Gene	Interference|nmod|START_ENTITY Interference|parataxis|enhances enhances|nsubj|co-stimulation co-stimulation|compound|END_ENTITY	Interference with PD-L1 / PD-1 co-stimulation during antigen presentation enhances the multifunctionality of antigen-specific T cells .
24506960	0	PD-L1	20,25	PD-1	15,19	PD-L1	PD-1	29126	5133	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of PD-1 / PD-L1 in peripheral blood mononuclear cells in lung_cancer patients and its biological significance -RSB- .
24626392	0	PD-L1	62,67	PD-1	68,72	PD-L1	PD-1	29126	100037293(Tax:9823)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Immune suppression by neutrophils in HIV-1_infection : role of PD-L1 / PD-1 pathway .
25047812	0	PD-L1	82,87	PD-1	25,29	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY function|nmod|cells regulates|dobj|function regulates|nsubj|death death|appos|END_ENTITY	Programmed cell death 1 -LRB- PD-1 -RRB- regulates the effector function of CD8 T cells via PD-L1 expressed on target keratinocytes .
25248890	0	PD-L1	20,25	PD-1	15,19	PD-L1	PD-1	29126	5133	Gene	Gene	Targeting|parataxis|START_ENTITY Targeting|dep|END_ENTITY	-LSB- Targeting the PD-1 / PD-L1 immune checkpoint signal - a new treatment strategy for cancer -RSB- .
25342040	0	PD-L1	18,23	PD-1	13,17	PD-L1	PD-1	29126	5133	Gene	Gene	Pathway|compound|START_ENTITY Advances|dep|Pathway Advances|nmod|END_ENTITY	-LSB- Advances of PD-1 / PD-L1 Signaling Pathway in Immune Escape and Treatment for Non-small_Cell_Lung_Cancer -RSB- .
25349132	0	PD-L1	6,11	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	PD-L2|amod|START_ENTITY PD-L2|amod|END_ENTITY	PD-1 , PD-L1 , PD-L2 expression in the chordoma microenvironment .
25392179	0	PD-L1	47,52	PD-1	25,29	PD-L1	PD-1	29126	5133	Gene	Gene	START_ENTITY|nsubj|Programmed_Cell_Death_1 Programmed_Cell_Death_1|appos|END_ENTITY	Programmed_Cell_Death_1 -LRB- PD-1 -RRB- and Its Ligand -LRB- PD-L1 -RRB- in Common Cancers and Their Correlation with Molecular Cancer Type .
25415283	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	Blockade|compound|START_ENTITY END_ENTITY|dep|Blockade	PD-1 / PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic_Tumors .
25433812	0	PD-L1	93,98	PD-1	88,92	PD-L1	PD-1	29126	5133	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Synovial T cell hyporesponsiveness to myeloid dendritic cells is reversed by preventing PD-1 / PD-L1 interactions .
25491730	0	PD-L1	9,14	PD-1	4,8	PD-L1	PD-1	29126	5133	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The PD-1 / PD-L1 pathway : biological background and clinical relevance of an emerging treatment target in immunotherapy .
25630305	0	PD-L1	58,63	PD-1	53,57	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY subsets|dep|axis subsets|nmod|END_ENTITY	Differential control of CD4 -LRB- + -RRB- T-cell subsets by the PD-1 / PD-L1 axis in a mouse model of allergic_asthma .
25640631	0	PD-L1	41,46	PD-1	36,40	PD-L1	PD-1	574058(Tax:9823)	100037293(Tax:9823)	Gene	Gene	Pathway|compound|START_ENTITY Insight|dep|Pathway Insight|nmod|END_ENTITY	Recent Insight into the Role of the PD-1 / PD-L1 Pathway in Feto-Maternal Tolerance and Pregnancy .
25645798	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	Tolerance|compound|START_ENTITY END_ENTITY|dep|Tolerance	PD-1 / PD-L1 Costimulatory Pathway-induced Mouse Islet Transplantation Immune Tolerance .
25674748	0	PD-L1	76,81	PD-1	52,56	PD-L1	PD-1	29126	5133	Gene	Gene	Programmed_Cell_Death_1|appos|START_ENTITY Programmed_Cell_Death_1|appos|END_ENTITY	Prognostic Significance of Programmed_Cell_Death_1 -LRB- PD-1 -RRB- or PD-1_Ligand_1 -LRB- PD-L1 -RRB- Expression in Epithelial-Originated Cancer : A Meta-Analysis .
25691326	0	PD-L1	88,93	PD-1	83,87	PD-L1	PD-1	29126	5133	Gene	Gene	Blockade|compound|START_ENTITY Blockade|nmod|Synergizes Synergizes|nmod|END_ENTITY	Virotherapy with a Semliki_Forest_Virus-Based Vector Encoding IL12 Synergizes with PD-1 / PD-L1 Blockade .
25778100	0	PD-L1	0,5	PD-1	6,10	PD-L1	PD-1	29126	5133	Gene	Gene	START_ENTITY|dep|presence presence|compound|END_ENTITY	PD-L1 / PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma .
25778100	0	PD-L1	0,5	PD-1	66,70	PD-L1	PD-1	29126	5133	Gene	Gene	START_ENTITY|dep|presence presence|nmod|microenvironment microenvironment|nmod|blockade blockade|compound|END_ENTITY	PD-L1 / PD-1 presence in the tumor microenvironment and activity of PD-1 blockade in multiple myeloma .
25823918	0	PD-L1	44,49	PD-1	39,43	PD-L1	PD-1	29126	5133	Gene	Gene	Blockade|compound|START_ENTITY Inhibitors|dep|Blockade Inhibitors|dep|END_ENTITY	The Next Immune-Checkpoint Inhibitors : PD-1 / PD-L1 Blockade in Melanoma .
25901287	0	PD-L1	47,52	PD-1	42,46	PD-L1	PD-1	29126	5133	Gene	Gene	checkpoint|compound|START_ENTITY checkpoint|compound|END_ENTITY	The therapeutic promise of disrupting the PD-1 / PD-L1 immune checkpoint in cancer : unleashing the CD8 T cell mediated anti-tumor activity results in significant , unprecedented clinical efficacy in various solid tumors .
25914862	0	PD-L1	127,132	PD-1	30,34	PD-L1	PD-1	574058(Tax:9823)	100037293(Tax:9823)	Gene	Gene	blockade|compound|START_ENTITY Unleashing|parataxis|blockade Unleashing|dep|END_ENTITY	Unleashing the immune system : PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1 / PD-L1 blockade .
25919090	0	PD-L1	19,24	PD-1	14,18	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	Axis|compound|START_ENTITY Axis|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the PD-1 / PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers .
25919090	0	PD-L1	19,24	PD-1	14,18	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	Axis|compound|START_ENTITY Axis|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the PD-1 / PD-L1 Immune Evasion Axis With DNA Aptamers as a Novel Therapeutic Strategy for the Treatment of Disseminated Cancers .
25944714	0	PD-L1	15,20	PD-1	10,14	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Associated|nsubj|Expression END_ENTITY|parataxis|Associated	Decreased PD-1 / PD-L1 Expression Is Associated with the Reduction in Mucosal Immunoglobulin A in Mice with Intestinal_Ischemia Reperfusion .
25944714	0	PD-L1	15,20	PD-1	10,14	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Associated|nsubj|Expression END_ENTITY|parataxis|Associated	Decreased PD-1 / PD-L1 Expression Is Associated with the Reduction in Mucosal Immunoglobulin A in Mice with Intestinal_Ischemia Reperfusion .
26005519	0	PD-L1	23,28	PD-1	18,22	PD-L1	PD-1	29126	5133	Gene	Gene	Pathway|compound|START_ENTITY Mobilize|nsubj|Pathway Inhibitors|parataxis|Mobilize Inhibitors|nmod|END_ENTITY	Inhibitors of the PD-1 / PD-L1 Pathway Can Mobilize the Immune System : An Innovative Potential Therapy for Cancer and Chronic_Infections .
26047524	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	inhibitors|nsubj|START_ENTITY END_ENTITY|appos|inhibitors	PD-1 / PD-L1 inhibitors .
26091678	0	PD-L1	66,71	PD-1	61,65	PD-L1	PD-1	29126	5133	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	Hematologic_Cancers Break Down a ` Checkpoint ' : Targeting the PD-1 / PD-L1 Axis .
26259671	0	PD-L1	21,26	PD-1	16,20	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	Interaction|compound|START_ENTITY Blocking|dep|Interaction Blocking|nmod|END_ENTITY	Blocking of the PD-1 / PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy .
26279307	0	PD-L1	20,25	PD-1	15,19	PD-L1	PD-1	29126	5133	Gene	Gene	Pathway|compound|START_ENTITY Development|dep|Pathway Development|nmod|END_ENTITY	Development of PD-1 / PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small_Cell_Lung_Cancer .
26279307	0	PD-L1	20,25	PD-1	15,19	PD-L1	PD-1	29126	5133	Gene	Gene	Pathway|compound|START_ENTITY Development|dep|Pathway Development|nmod|END_ENTITY	Development of PD-1 / PD-L1 Pathway in Tumor Immune Microenvironment and Treatment for Non-Small_Cell_Lung_Cancer .
26286967	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	signal|compound|START_ENTITY participates|nsubj|signal END_ENTITY|appos|participates	PD-1 / PD-L1 signal pathway participates in HCV F protein-induced T cell dysfunction in chronic HCV_infection .
26346135	0	PD-L1	42,47	PD-1	37,41	PD-L1	PD-1	29126	5133	Gene	Gene	blockade|compound|START_ENTITY blockade|nmod|therapies therapies|nmod|END_ENTITY	Efficacy of targeted therapies after PD-1 / PD-L1 blockade in metastatic renal_cell_carcinoma .
26346135	0	PD-L1	42,47	PD-1	37,41	PD-L1	PD-1	29126	5133	Gene	Gene	blockade|compound|START_ENTITY blockade|nmod|therapies therapies|nmod|END_ENTITY	Efficacy of targeted therapies after PD-1 / PD-L1 blockade in metastatic renal_cell_carcinoma .
26373277	0	PD-L1	72,77	PD-1	67,71	PD-L1	PD-1	29126	5133	Gene	Gene	Axis|compound|START_ENTITY Axis|dep|END_ENTITY	FcyRs Modulate the Anti-tumor Activity of Antibodies Targeting the PD-1 / PD-L1 Axis .
26446939	0	PD-L1	161,166	PD-1	167,171	PD-L1	PD-1	574058(Tax:9823)	5133	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|axis axis|compound|END_ENTITY	The PD-L1 / CD86 ratio is increased in dendritic cells co-infected with porcine_circovirus_type_2 and porcine_reproductive_and_respiratory_syndrome_virus , and the PD-L1 / PD-1 axis is associated with anergy , apoptosis , and the induction of regulatory T-cells in porcine lymphocytes .
26446939	0	PD-L1	4,9	PD-1	167,171	PD-L1	PD-1	29126	5133	Gene	Gene	START_ENTITY|dep|PD-L1 PD-L1|parataxis|associated associated|nsubjpass|axis axis|compound|END_ENTITY	The PD-L1 / CD86 ratio is increased in dendritic cells co-infected with porcine_circovirus_type_2 and porcine_reproductive_and_respiratory_syndrome_virus , and the PD-L1 / PD-1 axis is associated with anergy , apoptosis , and the induction of regulatory T-cells in porcine lymphocytes .
26448693	0	PD-L1	37,42	PD-1	32,36	PD-L1	PD-1	29126	5133	Gene	Gene	Blockade|compound|START_ENTITY Blockade|compound|END_ENTITY	Human Cancer Immunotherapy with PD-1 / PD-L1 Blockade .
26515496	0	PD-L1	157,162	PD-1	152,156	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|compound|END_ENTITY	RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast_Cancer : Therapeutic Cooperation Between MEK and PD-1 / PD-L1 Immune Checkpoint Inhibitors .
26559787	0	PD-L1	37,42	PD-1	32,36	PD-L1	PD-1	29126	5133	Gene	Gene	inhibitors|compound|START_ENTITY assays|dep|inhibitors assays|nmod|END_ENTITY	Companion diagnostic assays for PD-1 / PD-L1 checkpoint inhibitors in NSCLC .
26582228	0	PD-L1	41,46	PD-1	36,40	PD-L1	PD-1	29126	5133	Gene	Gene	Antibody|compound|START_ENTITY Progress|dep|Antibody Progress|nmod|END_ENTITY	-LSB- Clinical Research Progress of Anti PD-1 / PD-L1 Monoclonal Antibody in the Treatment of Lung_Cancer -RSB- .
26589760	0	PD-L1	30,35	PD-1	25,29	PD-L1	PD-1	29126	5133	Gene	Gene	immunotherapy|compound|START_ENTITY immunotherapy|compound|END_ENTITY	Predictive biomarkers in PD-1 / PD-L1 checkpoint blockade immunotherapy .
26619015	0	PD-L1	41,46	PD-1	36,40	PD-L1	PD-1	29126	5133	Gene	Gene	Inhibitors|compound|START_ENTITY Challenges|dep|Inhibitors Challenges|nmod|END_ENTITY	Challenges to Biomarker Testing for PD-1 / PD-L1 Checkpoint Inhibitors for Lung_Cancer .
26859684	0	PD-L1	23,28	PD-1	18,22	PD-L1	PD-1	29126	5133	Gene	Gene	checkpoint|compound|START_ENTITY checkpoint|compound|END_ENTITY	Activation of the PD-1 / PD-L1 immune checkpoint confers tumor cell chemoresistance associated with increased metastasis .
26871284	0	PD-L1	24,29	PD-1	30,34	PD-L1	PD-1	29126	5133	Gene	Gene	Implication|nmod|START_ENTITY Implication|dep|blockade blockade|compound|END_ENTITY	Implication of combined PD-L1 / PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal_cancer .
26895815	0	PD-L1	0,5	PD-1	51,55	PD-L1	PD-1	29126	5133	Gene	Gene	expression|compound|START_ENTITY expression|nmod|patients patients|acl|receiving receiving|dobj|antibodies antibodies|compound|END_ENTITY	PD-L1 expression in cancer patients receiving anti PD-1 / PD-L1 antibodies : A systematic review and meta-analysis .
26895815	0	PD-L1	56,61	PD-1	51,55	PD-L1	PD-1	29126	5133	Gene	Gene	antibodies|compound|START_ENTITY antibodies|compound|END_ENTITY	PD-L1 expression in cancer patients receiving anti PD-1 / PD-L1 antibodies : A systematic review and meta-analysis .
26899259	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	blockade|compound|START_ENTITY END_ENTITY|dep|blockade	PD-1 / PD-L1 blockade in cancer treatment : perspectives and issues .
26968586	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	blockage|nsubj|START_ENTITY END_ENTITY|appos|blockage	PD-1 / PD-L1 blockage in cancer treatment-from basic research to clinical application .
27057446	0	PD-L1	14,19	PD-1	9,13	PD-L1	PD-1	60533(Tax:10090)	18566(Tax:10090)	Gene	Gene	administration|compound|START_ENTITY induces|nsubj|administration END_ENTITY|parataxis|induces	Repeated PD-1 / PD-L1 monoclonal antibody administration induces fatal xenogeneic_hypersensitivity_reactions in a murine model of breast_cancer .
27058572	0	PD-L1	5,10	PD-1	0,4	PD-L1	PD-1	29126	5133	Gene	Gene	immune|amod|START_ENTITY blockade|amod|immune END_ENTITY|dep|blockade	PD-1 / PD-L1 immune checkpoint blockade in non-small_cell_lung_cancer .
26895815	0	PD-L1	0,5	PD-L1	56,61	PD-L1	PD-L1	29126	29126	Gene	Gene	expression|compound|START_ENTITY expression|nmod|patients patients|acl|receiving receiving|dobj|antibodies antibodies|compound|END_ENTITY	PD-L1 expression in cancer patients receiving anti PD-1 / PD-L1 antibodies : A systematic review and meta-analysis .
26895815	0	PD-L1	56,61	PD-L1	0,5	PD-L1	PD-L1	29126	29126	Gene	Gene	antibodies|compound|START_ENTITY receiving|dobj|antibodies patients|acl|receiving expression|nmod|patients expression|compound|END_ENTITY	PD-L1 expression in cancer patients receiving anti PD-1 / PD-L1 antibodies : A systematic review and meta-analysis .
26314420	0	PD-L1	42,47	Programmed_Death_Ligand-1	15,40	PD-L1	Programmed Death Ligand-1	29126	29126	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of Programmed_Death_Ligand-1 -LRB- PD-L1 -RRB- in Human Acute Leukemia and Its Clinical Significance -RSB- .
25499621	0	PD-L1	33,38	miR-34a	17,24	PD-L1	miR-34a	29126	407040	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute_myeloid_leukemia .
16265694	0	PD-L1	49,54	programmed_death-1	23,41	PD-L1	programmed death-1	29126	5133	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of programmed_death-1 -LRB- PD-1 -RRB- / PD-L1 in salivary glands of patients with Sj __ gren 's _ syndrome .
16530813	0	PD-L1	65,70	programmed_death-1_ligand-1	36,63	PD-L1	programmed death-1 ligand-1	29126	29126	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of programmed_death-1_ligand-1 -LRB- PD-L1 -RRB- in gastric_carcinoma and its clinical significance .
24696476	0	PD-L1	26,31	tumor_necrosis_factor_alpha	78,105	PD-L1	tumor necrosis factor alpha	60533(Tax:10090)	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	HIV-1 Tat protein induces PD-L1 _ -LRB- B7-H1 -RRB- expression on dendritic cells through tumor_necrosis_factor_alpha - and toll-like_receptor_4-mediated mechanisms .
19710692	0	PD-L2	43,48	Octamer_binding_protein_2	0,25	PD-L2	Octamer binding protein 2	80380	5452	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Octamer_binding_protein_2 -LRB- Oct2 -RRB- regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique , intronic promoter .
24376539	0	PD-L2	15,20	TLR2	0,4	PD-L2	TLR2	574057(Tax:9823)	101055400	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TLR2 directing PD-L2 expression inhibit T cells response in Schistosoma_japonicum infection .
16613922	0	PD-L2	42,47	programmed_death-ligand_2	15,40	PD-L2	programmed death-ligand 2	58205(Tax:10090)	58205(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of programmed_death-ligand_2 -LRB- PD-L2 -RRB- in the development of experimental_allergic_conjunctivitis in mice .
18811584	0	PD1	144,147	CCL27	111,116	PD1	CCL27	6622	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PD1	144,147	CCR4	125,129	PD1	CCR4	6622	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PD1	144,147	CCR5	131,135	PD1	CCR5	6622	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
27038842	0	PD1	35,38	CD103	0,5	PD1	CD103	5133	3682	Gene	Gene	+|compound|START_ENTITY lymphocytes|nsubj|+ defines|xcomp|lymphocytes defines|nsubj|END_ENTITY	CD103 defines intraepithelial CD8 + PD1 + tumour-infiltrating lymphocytes of prognostic significance in endometrial_adenocarcinoma .
17440051	0	PD1	49,52	CD8	13,16	PD1	CD8	5133	925	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|cells cells|compound|END_ENTITY	SIV-specific CD8 + T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection .
22503210	0	PD1	87,90	CD8	40,43	PD1	CD8	5133	925	Gene	Gene	express|dobj|START_ENTITY modified|xcomp|express cells|acl|modified cells|nsubj|END_ENTITY	Tumor PD-L1 co-stimulates primary human CD8 -LRB- + -RRB- cytotoxic T cells modified to express a PD1 : CD28 chimeric receptor .
23587922	0	PD1	75,78	CD8	41,44	PD1	CD8	5133	925	Gene	Gene	vaccine|compound|START_ENTITY Potentiating|nmod|vaccine Potentiating|dobj|immunity immunity|compound|END_ENTITY	Potentiating functional antigen-specific CD8 T cell immunity by a novel PD1 isoform-based fusion DNA vaccine .
26154582	0	PD1	63,66	CD8	12,15	PD1	CD8	18566(Tax:10090)	925	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Cells Cells|compound|END_ENTITY	The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1 - / - Mice Cotreated with Anti-CTLA-4 .
26208901	0	PD1	44,47	CD8	32,35	PD1	CD8	100037293(Tax:9823)	925	Gene	Gene	Response|compound|START_ENTITY +|dobj|Response +|nsubj|Level Level|nmod|END_ENTITY	A Threshold Level of Intratumor CD8 + T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1 .
27038842	0	PD1	35,38	CD8	30,33	PD1	CD8	5133	925	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD103 defines intraepithelial CD8 + PD1 + tumour-infiltrating lymphocytes of prognostic significance in endometrial_adenocarcinoma .
18811584	0	PD1	144,147	CXCR3	137,142	PD1	CXCR3	6622	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PD1	144,147	IFN-beta	161,169	PD1	IFN-beta	6622	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PD1	144,147	IP-10	118,123	PD1	IP-10	6622	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PD1	144,147	MIP-1alpha	99,109	PD1	MIP-1alpha	6622	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PD1	144,147	PDL2	149,153	PD1	PDL2	6622	80380	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
24586872	0	PD1	36,39	programmed_death-1	16,34	PD1	programmed death-1	18566(Tax:10090)	18566(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Blockade of the programmed_death-1 -LRB- PD1 -RRB- pathway undermines potent genetic protection from type 1 diabetes .
8188267	0	PDC	42,45	phosducin	26,35	PDC	phosducin	5132	5132	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The sequence of the human phosducin gene -LRB- PDC -RRB- and its 5 ' - flanking region .
8288249	0	PDC	29,32	phosducin	18,27	PDC	phosducin	5132	5132	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the phosducin -LRB- PDC -RRB- gene to human chromosome 1q25-1q32 .1 by somatic cell hybridization and in situ hybridization .
8646891	0	PDC	125,128	phosducin	109,118	PDC	phosducin	5132	5132	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fine mapping of the autosomal_recessive_retinitis_pigmentosa locus -LRB- RP12 -RRB- on chromosome 1q ; exclusion of the phosducin gene -LRB- PDC -RRB- .
10385636	0	PDC-E2	34,40	OGDC-E1	91,98	PDC-E2	OGDC-E1	1737	4967	Gene	Gene	detection|nmod|START_ENTITY detection|amod|END_ENTITY	In situ nucleic acid detection of PDC-E2 , BCOADC-E2 , OGDC-E2 , PDC-E1alpha , BCOADC-E1alpha , OGDC-E1 , and the E3 binding protein -LRB- protein X -RRB- in primary_biliary_cirrhosis .
25494835	0	PDC1	103,107	Thi3p	94,99	PDC1	Thi3p	850733(Tax:4932)	851479(Tax:4932)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Deciphering regulatory variation of THI genes in alcoholic fermentation indicate an impact of Thi3p on PDC1 expression .
7851902	0	PDCD1	63,68	PD-1	52,56	PDCD1	PD-1	5133	5133	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and chromosomal localization of the human PD-1 gene -LRB- PDCD1 -RRB- .
17360971	0	PDCD10	0,6	MST4	43,47	PDCD10	MST4	11235	51765	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PDCD10 interacts with Ste20-related_kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway .
22652780	0	PDCD10	0,6	STK25	22,27	PDCD10	STK25	11235	10494	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress .
17468402	0	PDCD2	18,23	BCL6	32,36	PDCD2	BCL6	5134	604	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas .
12149646	0	PDCD2	0,5	HCF-1	33,38	PDCD2	HCF-1	5134	3054	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PDCD2 is a negative regulator of HCF-1 -LRB- C1 -RRB- .
11854457	0	PDCD2	35,40	programmed_cell_death-2	10,33	PDCD2	programmed cell death-2	5134	5134	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human programmed_cell_death-2 -LRB- PDCD2 -RRB- gene is a target of BCL6 repression : implications for a role of BCL6 in the down-regulation of apoptosis .
24434439	0	PDCD4	59,64	CD4	79,82	PDCD4	CD4	27250	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Effect of intensive atorvastatin therapy on periprocedural PDCD4 expression in CD4 + T lymphocytes of patients with unstable_angina undergoing percutaneous coronary intervention .
23904372	0	PDCD4	77,82	MiR-21	0,6	PDCD4	MiR-21	27250	406991	Gene	Gene	regulating|dobj|START_ENTITY mediates|advcl|regulating mediates|nsubj|END_ENTITY	MiR-21 mediates the radiation resistance of glioblastoma cells by regulating PDCD4 and hMSH2 .
24609942	0	PDCD4	100,105	MiR-21	0,6	PDCD4	MiR-21	27250	406991	Gene	Gene	targeting|dobj|START_ENTITY cisplatin|advcl|targeting modulates|xcomp|cisplatin modulates|nsubj|END_ENTITY	MiR-21 modulates chemosensitivity of tongue_squamous_cell_carcinoma cells to cisplatin by targeting PDCD4 .
20533548	0	PDCD4	80,85	Micro-RNA-21	0,12	PDCD4	Micro-RNA-21	27250	406991	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	Micro-RNA-21 regulates TGF-b-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction .
25012722	0	PDCD4	102,107	MicroRNA-182	0,12	PDCD4	MicroRNA-182	27250	406958	Gene	Gene	targeting|dobj|START_ENTITY cisplatin|advcl|targeting modulates|xcomp|cisplatin modulates|nsubj|END_ENTITY	MicroRNA-182 modulates chemosensitivity of human non-small_cell_lung_cancer to cisplatin by targeting PDCD4 .
19013014	0	PDCD4	62,67	MicroRNA-21	0,11	PDCD4	MicroRNA-21	27250	406991	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G .
19336275	0	PDCD4	97,102	MicroRNA-21	0,11	PDCD4	MicroRNA-21	27250	406991	Gene	Gene	injury_on_cardiac_myocytes|nmod|START_ENTITY protects|dobj|injury_on_cardiac_myocytes protects|nsubj|END_ENTITY	MicroRNA-21 protects against the H -LRB- 2 -RRB- O -LRB- 2 -RRB- - induced injury_on_cardiac_myocytes via its target gene PDCD4 .
22526161	0	PDCD4	130,135	MicroRNA-21	0,11	PDCD4	MicroRNA-21	27250	406991	Gene	Gene	programmed_cell_death_protein_4|appos|START_ENTITY correlates|nmod|programmed_cell_death_protein_4 correlates|amod|END_ENTITY	MicroRNA-21 correlates with tumorigenesis in malignant_peripheral_nerve_sheath_tumor -LRB- MPNST -RRB- via programmed_cell_death_protein_4 -LRB- PDCD4 -RRB- .
24902663	0	PDCD4	75,80	MicroRNA-21	0,11	PDCD4	MicroRNA-21	27250	406991	Gene	Gene	tumor|dobj|START_ENTITY tumor|nsubj|downregulates downregulates|amod|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation , proliferation , and metastasis in renal_cell_carcinoma .
25520758	0	PDCD4	55,60	MicroRNA-21	0,11	PDCD4	MicroRNA-21	27250	406991	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma .
20702469	0	PDCD4	25,30	Programmed_cell_death_4	0,23	PDCD4	Programmed cell death 4	27250	27250	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Programmed_cell_death_4 -LRB- PDCD4 -RRB- expression during multistep Barrett 's _ carcinogenesis .
25520758	0	PDCD4	55,60	Rb1	27,30	PDCD4	Rb1	27250	5925	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma .
19946272	0	PDCD4	82,87	TLR4	23,27	PDCD4	TLR4	27250	7099	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 .
17991735	0	PDCD4	25,30	miR-21	82,88	PDCD4	miR-21	27250	406991	Gene	Gene	Programmed_cell_death_4|appos|START_ENTITY target|nsubj|Programmed_cell_death_4 target|nmod|END_ENTITY	Programmed_cell_death_4 -LRB- PDCD4 -RRB- is an important functional target of the microRNA miR-21 in breast_cancer cells .
19473551	0	PDCD4	44,49	miR-21	14,20	PDCD4	miR-21	27250	406991	Gene	Gene	PTEN|dep|START_ENTITY Expression|appos|PTEN Expression|nmod|END_ENTITY	Expression of miR-21 and its targets -LRB- PTEN , PDCD4 , TM1 -RRB- in flat_epithelial_atypia_of_the_breast in relation to ductal_carcinoma_in_situ and invasive_carcinoma .
20219857	0	PDCD4	133,138	miR-21	36,42	PDCD4	miR-21	64031(Tax:10116)	100314000(Tax:10116)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4 .
21279518	0	PDCD4	0,5	miR-21	45,51	PDCD4	miR-21	27250	406991	Gene	Gene	loss|nummod|START_ENTITY correlates|nsubj|loss correlates|nmod|levels levels|amod|END_ENTITY	PDCD4 nuclear loss inversely correlates with miR-21 levels in colon_carcinogenesis .
21602271	0	PDCD4	166,171	miR-21	101,107	PDCD4	miR-21	27250	406991	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression responses|nmod|regulation regulates|dobj|responses regulates|nsubj|END_ENTITY	Identification of novel microRNA signatures linked to human lupus_disease activity and pathogenesis : miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression .
22212233	0	PDCD4	0,5	miR-21	43,49	PDCD4	miR-21	27250	406991	Gene	Gene	expression|compound|START_ENTITY correlated|nsubj|expression correlated|nmod|levels levels|amod|END_ENTITY	PDCD4 expression inversely correlated with miR-21 levels in gastric_cancers .
22353043	0	PDCD4	125,130	miR-21	118,124	PDCD4	miR-21	27250	406991	Gene	Gene	pathway|nummod|START_ENTITY apoptosis|nsubj|pathway apoptosis|dobj|U251 U251|nmod|TGF-b1 TGF-b1|dep|END_ENTITY	Ursolic_acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-b1 / miR-21 / PDCD4 pathway .
23824073	0	PDCD4	70,75	miR-21	63,69	PDCD4	miR-21	27250	406991	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Berberine sensitizes ovarian_cancer cells to cisplatin through miR-21 / PDCD4 axis .
23888942	0	PDCD4	29,34	miR-21	82,88	PDCD4	miR-21	27250	406991	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|patients patients|nmod|gastric_cancer gastric_cancer|nmod|END_ENTITY	Oxidative stress upregulates PDCD4 expression in patients with gastric_cancer via miR-21 .
24902663	0	PDCD4	75,80	miR-21	13,19	PDCD4	MiR-21	27250	406991	Gene	Gene	tumor|dobj|START_ENTITY tumor|nsubj|downregulates downregulates|dep|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation , proliferation , and metastasis in renal_cell_carcinoma .
26212010	0	PDCD4	99,104	miR-21	80,86	PDCD4	miR-21	27250	406991	Gene	Gene	downregulation|dep|START_ENTITY downregulation|amod|END_ENTITY	Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression , PDCD4 downregulation and breast_cancer metastasis .
26252635	0	PDCD4	41,46	miR-21	50,56	PDCD4	miR-21	27250	406991	Gene	Gene	Modulation|nmod|START_ENTITY Inhibits|dobj|Modulation Inhibits|nmod|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
26252635	0	PDCD4	41,46	miR-21	50,56	PDCD4	miR-21	27250	406991	Gene	Gene	Modulation|nmod|START_ENTITY Inhibits|dobj|Modulation Inhibits|nmod|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
26595526	0	PDCD4	60,65	miR-21	76,82	PDCD4	miR-21	27250	406991	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|mechanism mechanism|amod|dependent dependent|amod|END_ENTITY	ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism .
21088996	0	PDCD4	111,116	microRNA-21	13,24	PDCD4	microRNA-21	27250	406991	Gene	Gene	programmed_cell_death_4|appos|START_ENTITY death|nmod|programmed_cell_death_4 inhibits|dobj|death inhibits|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed_cell_death_4 -LRB- PDCD4 -RRB- in pancreatic_ductal_adenocarcinoma .
21983937	0	PDCD4	56,61	microRNA-21	15,26	PDCD4	microRNA-21	27250	406991	Gene	Gene	targets|appos|START_ENTITY Association|nmod|targets Association|nmod|expression expression|amod|END_ENTITY	Association of microRNA-21 expression with its targets , PDCD4 and TIMP3 , in pancreatic_ductal_adenocarcinoma .
22267128	0	PDCD4	27,32	microRNA-21	65,76	PDCD4	microRNA-21	27250	406991	Gene	Gene	expression|compound|START_ENTITY significance|nmod|expression significance|nmod|patients patients|amod|END_ENTITY	Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes ' stage of colorectal_cancer patients .
23827854	0	PDCD4	127,132	microRNA-21	81,92	PDCD4	microRNA-21	27250	406991	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Aldose reductase inhibition suppresses colon_cancer cell viability by modulating microRNA-21 mediated programmed_cell_death_4 -LRB- PDCD4 -RRB- expression .
26943153	0	PDCD4	88,93	microRNA-21	126,137	PDCD4	microRNA-21	27250	406991	Gene	Gene	Up-Regulation|compound|START_ENTITY Up-Regulation|nmod|END_ENTITY	PDGF-BB Enhances the Proliferation of Cells in Human Orbital Fibroblasts by Suppressing PDCD4 Expression Via Up-Regulation of microRNA-21 .
20455770	0	PDCD4	19,24	programmed_cell_death_4	26,49	PDCD4	programmed cell death 4	18569(Tax:10090)	18569(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Decreased level of PDCD4 -LRB- programmed_cell_death_4 -RRB- protein activated cell proliferation in the lung of A/J mouse .
22586265	0	PDCD4	47,52	programmed_cell_death_4	22,45	PDCD4	programmed cell death 4	27250	27250	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Regulatory effects of programmed_cell_death_4 -LRB- PDCD4 -RRB- protein in interferon -LRB- IFN -RRB- - stimulated gene expression and generation of type I IFN responses .
23827854	0	PDCD4	127,132	programmed_cell_death_4	102,125	PDCD4	programmed cell death 4	27250	27250	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Aldose reductase inhibition suppresses colon_cancer cell viability by modulating microRNA-21 mediated programmed_cell_death_4 -LRB- PDCD4 -RRB- expression .
25519906	0	PDCD4	60,65	programmed_cell_death_4	35,58	PDCD4	programmed cell death 4	27250	27250	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Post-transcriptional regulation of programmed_cell_death_4 -LRB- PDCD4 -RRB- mRNA by the RNA-binding proteins human antigen R -LRB- HuR -RRB- and T-cell_intracellular_antigen_1 -LRB- TIA1 -RRB- .
19761702	0	PDCD4	47,52	programmed_cell_death_factor_4	15,45	PDCD4	programmed cell death factor 4	27250	27250	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of programmed_cell_death_factor_4 -LRB- PDCD4 -RRB- with hepatocellular_carcinoma and smoking in a Chinese male population .
24982420	0	PDCD4	64,69	programmed_cell_death_protein_4	31,62	PDCD4	programmed cell death protein 4	27250	27250	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	LPS induces the degradation of programmed_cell_death_protein_4 -LRB- PDCD4 -RRB- to release Twist2 , activating c-Maf transcription to promote interleukin-10 production .
25499082	0	PDCD5	59,64	OTUD5	15,20	PDCD5	OTUD5	9141	55593	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress .
16793605	0	PDCD5	22,27	TFAR19	15,21	PDCD5	TFAR19	9141	9141	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of TFAR19 -LRB- PDCD5 -RRB- in normal human kidney , renal_clear_cell_carcinoma , normal human bladder_and_bladder_carcinoma -RSB- .
19308289	0	PDCD5	0,5	Tip60	21,26	PDCD5	Tip60	9141	10524	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis .
22914926	0	PDCD5	0,5	p53	21,24	PDCD5	p53	9141	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway .
22914926	0	PDCD5	0,5	p53	70,73	PDCD5	p53	9141	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|regulator regulator|nmod|pathway pathway|compound|END_ENTITY	PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway .
26433055	0	PDCD5	0,5	p53	34,37	PDCD5	p53	9141	7157	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|regulator regulator|nmod|dynamics dynamics|compound|END_ENTITY	PDCD5 functions as a regulator of p53 dynamics in the DNA damage response .
27056106	0	PDCD5	17,22	p53	38,41	PDCD5	p53	9141	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Corrigendum to '' PDCD5 interacts with p53 and functions as a regulator of p53 dynamics in the DNA damage response '' -LSB- J. Theor .
27056106	0	PDCD5	17,22	p53	74,77	PDCD5	p53	9141	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|regulator regulator|nmod|dynamics dynamics|compound|END_ENTITY	Corrigendum to '' PDCD5 interacts with p53 and functions as a regulator of p53 dynamics in the DNA damage response '' -LSB- J. Theor .
14601303	0	PDCD5	46,51	programmed_cell_death_5	21,44	PDCD5	programmed cell death 5	9141	9141	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Characterization of programmed_cell_death_5 -LRB- PDCD5 -RRB- gene in human cartilage and its possible significance -RSB- .
23327497	0	PDCD5	51,56	programmed_cell_death_5	26,49	PDCD5	programmed cell death 5	9141	9141	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Plasma and synovial fluid programmed_cell_death_5 -LRB- PDCD5 -RRB- levels are inversely associated with TNF-a and disease activity in patients with rheumatoid_arthritis .
23638963	0	PDCD5	44,49	programmed_cell_death_5	19,42	PDCD5	programmed cell death 5	9141	9141	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	The involvement of programmed_cell_death_5 -LRB- PDCD5 -RRB- in the regulation of apoptosis in cerebral_ischemia / reperfusion injury .
24614334	0	PDCD5	46,51	programmed_cell_death_5	21,44	PDCD5	programmed cell death 5	292814(Tax:10116)	292814(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Autophagic effect of programmed_cell_death_5 -LRB- PDCD5 -RRB- after focal cerebral ischemic_reperfusion_injury in rats .
23656249	0	PDCD5	39,44	programmed_cell_death_protein_5	6,37	PDCD5	programmed cell death protein 5	9141	9141	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum programmed_cell_death_protein_5 -LRB- PDCD5 -RRB- levels is upregulated in liver_diseases .
23613014	0	PDE-5	130,135	phosphodiesterase-5	109,128	PDE-5	phosphodiesterase-5	8654	8654	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Decreased permeability surface area for glucose in obese women with postprandial_hyperglycemia : no effect of phosphodiesterase-5 -LRB- PDE-5 -RRB- inhibition .
25087294	0	PDE-5	113,118	phosphodiesterase-5	92,111	PDE-5	phosphodiesterase-5	8654	8654	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Exercise training improves erectile_dysfunction -LRB- ED -RRB- in patients with metabolic_syndrome on phosphodiesterase-5 -LRB- PDE-5 -RRB- inhibitors .
25384088	0	PDE10A	190,196	Phosphodiesterase_10A	167,188	PDE10A	Phosphodiesterase 10A	23984(Tax:10090)	23984(Tax:10090)	Gene	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Discovery of 1 - -LSB- 2-Fluoro-4 - -LRB- 1H-pyrazol-1-yl -RRB- phenyl -RSB- -5 - methoxy-3 - -LRB- 1-phenyl-1H-pyrazol-5-yl -RRB- pyridazin-4 -LRB- 1H -RRB- - one -LRB- TAK-063 -RRB- , a Highly Potent , Selective , and Orally Active Phosphodiesterase_10A -LRB- PDE10A -RRB- Inhibitor .
25495129	0	PDE10A	69,75	Phosphodiesterase_10A	46,67	PDE10A	Phosphodiesterase 10A	10846	10846	Gene	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Identification of a Novel Orally Bioavailable Phosphodiesterase_10A -LRB- PDE10A -RRB- Inhibitor with Efficacy in Animal Models of Schizophrenia .
21602043	0	PDE10A	64,70	phosphodiesterase_10A	41,62	PDE10A	phosphodiesterase 10A	10846	10846	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Triazoloquinazolines as a novel class of phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
22365755	0	PDE10A	116,122	phosphodiesterase_10A	93,114	PDE10A	phosphodiesterase 10A	63885(Tax:10116)	63885(Tax:10116)	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of potent , selective , and metabolically stable 4 - -LRB- pyridin-3-yl -RRB- cinnolines as novel phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
24421319	0	PDE10A	72,78	phosphodiesterase_10A	49,70	PDE10A	phosphodiesterase 10A	10846	10846	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacology of JNJ-42314415 , a centrally active phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitor : a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs .
26077491	0	PDE10A	99,105	phosphodiesterase_10A	76,97	PDE10A	phosphodiesterase 10A	63885(Tax:10116)	63885(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Discovery of -LSB- -LRB- 11 -RRB- C -RSB- MK-8193 as a PET tracer to measure target engagement of phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
26113188	0	PDE10A	72,78	phosphodiesterase_10A	49,70	PDE10A	phosphodiesterase 10A	10846	10846	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
26113188	0	PDE10A	72,78	phosphodiesterase_10A	49,70	PDE10A	phosphodiesterase 10A	10846	10846	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
26597534	0	PDE10A	145,151	phosphodiesterase_10A	122,143	PDE10A	phosphodiesterase 10A	10846	10846	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Fragment-assisted hit investigation involving integrated HTS and fragment screening : Application to the identification of phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
26055709	0	PDE12	34,39	Phosphodiesterase_12	12,32	PDE12	Phosphodiesterase 12	201626	201626	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Phosphodiesterase_12 -LRB- PDE12 -RRB- as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors .
21960012	0	PDE1B	45,50	phosphodiesterase_1B	23,43	PDE1B	phosphodiesterase 1B	281970(Tax:9913)	281970(Tax:9913)	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Genetic association of phosphodiesterase_1B -LRB- PDE1B -RRB- with carcass traits in Korean cattle .
25815146	0	PDE2	96,100	Phosphodiesterase_2	75,94	PDE2	Phosphodiesterase 2	81743(Tax:10116)	81743(Tax:10116)	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Pyrido -LSB- 4,3-e -RSB- -LSB- 1,2,4 -RSB- triazolo -LSB- 4,3-a -RSB- pyrazines as Selective , Brain Penetrant Phosphodiesterase_2 -LRB- PDE2 -RRB- Inhibitors .
10417351	0	PDE3B	61,66	phosphodiesterase_type_3B	34,59	PDE3B	phosphodiesterase type 3B	29516(Tax:10116)	29516(Tax:10116)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of phosphodiesterase_type_3B -LRB- PDE3B -RRB- in adipocytes in response to serine/threonine phosphatase inhibitors : deactivation of PDE3B in vitro by protein phosphatase type 2A .
18321743	0	PDE4	11,15	MK-0873	0,7	PDE4	MK-0873	5141	1476974(Tax:190192)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	MK-0873 , a PDE4 inhibitor , does not influence the pharmacokinetics of theophylline in healthy male volunteers .
18835163	0	PDE4	162,166	MK-0873	130,137	PDE4	MK-0873	5141	1476974(Tax:190192)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Optimization and structure-activity relationship of a series of 1-phenyl-1 ,8 - naphthyridin-4-one-3-carboxamides : identification of MK-0873 , a potent and effective PDE4 inhibitor .
21342916	0	PDE4	21,25	Phosphodiesterase_4	0,19	PDE4	Phosphodiesterase 4	5141	5141	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Phosphodiesterase_4 -LRB- PDE4 -RRB- regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane .
12773045	0	PDE4	66,70	phosphodiesterase-4	45,64	PDE4	phosphodiesterase-4	5141	5141	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Optimization of a tertiary alcohol series of phosphodiesterase-4 -LRB- PDE4 -RRB- inhibitors : structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity .
18311187	0	PDE4	63,67	phosphodiesterase-4	42,61	PDE4	phosphodiesterase-4	5141	5141	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Short-term or long-term treatments with a phosphodiesterase-4 -LRB- PDE4 -RRB- inhibitor result in opposing agonist-induced Ca -LRB- 2 + -RRB- responses in endothelial cells .
8651945	0	PDE4	70,74	phosphodiesterase_4	49,68	PDE4	phosphodiesterase 4	5141	5141	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Association of the anti-inflammatory activity of phosphodiesterase_4 -LRB- PDE4 -RRB- inhibitors with either inhibition of PDE4 catalytic activity or competition for -LSB- 3H -RSB- rolipram binding .
22245243	0	PDE4	0,4	tissue_plasminogen_activator	15,43	PDE4	tissue plasminogen activator	5141	100128998	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PDE4 regulates tissue_plasminogen_activator expression of human brain microvascular endothelial cells .
23451206	0	PDE4B	28,33	IL-2	40,44	PDE4B	IL-2	5142	3558	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid_cancer cells .
18593531	0	PDE4B	106,111	Phosphodiesterase_4B	84,104	PDE4B	Phosphodiesterase 4B	5142	5142	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Minimizing a QTL region for intramuscular fat content by characterizing the porcine Phosphodiesterase_4B -LRB- PDE4B -RRB- gene .
23451206	0	PDE4B	28,33	STAT5	53,58	PDE4B	STAT5	5142	6776	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid_cancer cells .
18329668	0	PDE4B	28,33	phosphodiesterase_4B	35,55	PDE4B	phosphodiesterase 4B	5142	5142	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Positive association of the PDE4B -LRB- phosphodiesterase_4B -RRB- gene with schizophrenia in the Japanese population .
18785206	0	PDE4B	70,75	phosphodiesterase_4B	48,68	PDE4B	phosphodiesterase 4B	5142	5142	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gene expression and association analyses of the phosphodiesterase_4B -LRB- PDE4B -RRB- gene in major_depressive_disorder in the Japanese population .
16543535	0	PDE4D	80,85	phosphodiesterase_4D	53,73	PDE4D	phosphodiesterase 4D	5144	5144	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of single nucleotide polymorphisms in the phosphodiesterase_4D gene -LRB- PDE4D -RRB- and their association with ischaemic_stroke in a large German cohort .
20540798	0	PDE4D	57,62	phosphodiesterase_4D	35,55	PDE4D	phosphodiesterase 4D	5144	5144	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Sex-differential genetic effect of phosphodiesterase_4D -LRB- PDE4D -RRB- on carotid_atherosclerosis .
23120769	0	PDE4D	61,66	phosphodiesterase_4D	39,59	PDE4D	phosphodiesterase 4D	5144	5144	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	-LSB- Association of cerebral_stroke with a phosphodiesterase_4D -LRB- PDE4D -RRB- gene polymorphism in the Moscow population -RSB- .
25126889	0	PDE4D	193,198	phosphodiesterase_4D	171,191	PDE4D	phosphodiesterase 4D	5144	5144	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis , biological evaluation , and molecular modeling of new 3 - -LRB- cyclopentyloxy -RRB- -4 - methoxybenzaldehyde_O - -LRB- 2 - -LRB- 2,6-dimethylmorpholino -RRB- -2 - oxoethyl -RRB- _ Oxime -LRB- GEBR-7b -RRB- related phosphodiesterase_4D -LRB- PDE4D -RRB- inhibitors .
22426465	0	PDE5	26,30	Phosphodiesterase_type_5	0,24	PDE5	Phosphodiesterase type 5	8654	8654	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Phosphodiesterase_type_5 -LRB- PDE5 -RRB- inhibition improves object recognition memory : indications for central and peripheral mechanisms .
10769052	0	PDE5	82,86	cGMP-binding_cGMP-specific_phosphodiesterase	36,80	PDE5	cGMP-binding cGMP-specific phosphodiesterase	8654	171115(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of cGMP-binding_cGMP-specific_phosphodiesterase -LRB- PDE5 -RRB- in rat tissues .
9445376	0	PDE5	90,94	cGMP-binding_cGMP-specific_phosphodiesterase	44,88	PDE5	cGMP-binding cGMP-specific phosphodiesterase	8654	8654	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of cGMP to both allosteric sites of cGMP-binding_cGMP-specific_phosphodiesterase -LRB- PDE5 -RRB- is required for its phosphorylation .
17690252	0	PDE5	35,39	phosphodiesterase-5	14,33	PDE5	phosphodiesterase-5	8654	8654	Gene	Gene	site|compound|START_ENTITY site|amod|END_ENTITY	Conversion of phosphodiesterase-5 -LRB- PDE5 -RRB- catalytic site to higher affinity by PDE5 inhibitors .
16913726	0	PDE5	83,87	phosphodiesterase_5	62,81	PDE5	phosphodiesterase 5	8654	8654	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitory activity as potential agents for treatment of erectile_dysfunction .
20400309	0	PDE5	95,99	phosphodiesterase_5	74,93	PDE5	phosphodiesterase 5	8654	8654	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	1 - -LRB- 2 - -LRB- 2,2,2-trifluoroethoxy -RRB- ethyl-1H-pyrazolo -LSB- 4,3-d -RSB- pyrimidines as potent phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitors .
20443228	0	PDE5	79,83	phosphodiesterase_5	58,77	PDE5	phosphodiesterase 5	8654	8654	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	1 - -LRB- 2-Ethoxyethyl -RRB- -1 H-pyrazolo -LSB- 4,3-d -RSB- pyrimidines as potent phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitors .
18854969	0	PDE5	41,45	phosphodiesterase_type_5	15,39	PDE5	phosphodiesterase type 5	8654	8654	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	-LSB- The basics of phosphodiesterase_type_5 -LRB- PDE5 -RRB- inhibition in urology -RSB- .
21714539	0	PDE5	118,122	phosphodiesterase_type_5	92,116	PDE5	phosphodiesterase type 5	8654	8654	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Utilization of halogen bond in lead optimization : a case study of rational design of potent phosphodiesterase_type_5 -LRB- PDE5 -RRB- inhibitors .
24497218	0	PDE8B	59,64	phosphodiesterase_8B	37,57	PDE8B	phosphodiesterase 8B	8622	8622	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Frequency and effect on serum TSH of phosphodiesterase_8B -LRB- PDE8B -RRB- gene polymorphisms in patients with sporadic nonautoimmune subclinical_hypothyroidism .
20550708	0	PDEF	127,131	PDEF	8,12	PDEF	PDEF	25803	25803	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Loss Loss|nmod|END_ENTITY	Loss of PDEF , a prostate-derived_Ets_factor is associated with aggressive phenotype of prostate_cancer : regulation of MMP_9 by PDEF .
20550708	0	PDEF	8,12	PDEF	127,131	PDEF	PDEF	25803	25803	Gene	Gene	Loss|nmod|START_ENTITY associated|nsubjpass|Loss associated|nmod|END_ENTITY	Loss of PDEF , a prostate-derived_Ets_factor is associated with aggressive phenotype of prostate_cancer : regulation of MMP_9 by PDEF .
10625666	0	PDEF	0,4	androgen_receptor	88,105	PDEF	androgen receptor	25803	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PDEF , a novel prostate epithelium-specific ets transcription factor , interacts with the androgen_receptor and activates prostate-specific_antigen gene expression .
8261797	0	PDE_beta	61,69	rod_cGMP_phosphodiesterase_beta_subunit	20,59	PDE beta	rod cGMP phosphodiesterase beta subunit	399653(Tax:9615)	399653(Tax:9615)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Confirmation of the rod_cGMP_phosphodiesterase_beta_subunit -LRB- PDE_beta -RRB- nonsense mutation in affected rcd-1 Irish setters in the UK and development of a diagnostic test .
8226792	0	PDGF	63,67	platelet-derived_growth_factor	31,61	PDGF	platelet-derived growth factor	397765(Tax:8355)	397765(Tax:8355)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Dominant-negative mutations of platelet-derived_growth_factor -LRB- PDGF -RRB- receptors .
25869208	0	PDGF-A	50,56	FoxM1	0,5	PDGF-A	FoxM1	5154	2305	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway .
22363152	0	PDGF-A	101,107	IGF-I	10,15	PDGF-A	IGF-I	5154	3479	Gene	Gene	Effect|nmod|START_ENTITY Related|nmod|Effect Related|nsubj|Effect Effect|nmod|END_ENTITY	Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B .
22363152	0	PDGF-A	101,107	IGF-I	74,79	PDGF-A	IGF-I	5154	3479	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B .
15777709	0	PDGF-A	19,25	Puralpha	0,8	PDGF-A	Puralpha	18590(Tax:10090)	19290(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Puralpha activates PDGF-A gene transcription via interactions with a G-rich , single-stranded region of the promoter .
10441165	0	PDGF-A	33,39	Th2	0,3	PDGF-A	Th2	18590(Tax:10090)	15111(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|compound|END_ENTITY	Th2 T cells expressing transgene PDGF-A serve as vectors for gene therapy in autoimmune_demyelinating_disease .
19966216	0	PDGF-A	0,6	fibronectin	25,36	PDGF-A	fibronectin	397765(Tax:8355)	397744(Tax:8355)	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation .
9527059	0	PDGF-A	54,60	platelet-derived_growth_factor-A	20,52	PDGF-A	platelet-derived growth factor-A	5154	5154	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of platelet-derived_growth_factor-A -LRB- PDGF-A -RRB- in gastric_carcinoma .
16977580	0	PDGF-A	51,57	platelet-derived_growth_factor-alpha	13,49	PDGF-A	platelet-derived growth factor-alpha	25266(Tax:10116)	25266(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Detection of platelet-derived_growth_factor-alpha -LRB- PDGF-A -RRB- protein in cells of Leydig lineage in the postnatal rat testis .
1694856	0	PDGF-A	8,14	transforming_growth_factor-beta	82,113	PDGF-A	transforming growth factor-beta	5154	7040	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming_growth_factor-beta .
18723570	0	PDGF-B	41,47	Egr-1	97,102	PDGF-B	Egr-1	24628(Tax:10116)	24330(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Mycophenolic_acid inhibits the autocrine PDGF-B synthesis and PDGF-BB-induced mRNA expression of Egr-1 in rat mesangial cells .
17144099	0	PDGF-B	50,56	IL-10	31,36	PDGF-B	IL-10	5155	3586	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
8287605	0	PDGF-B	78,84	IL-1_alpha	31,41	PDGF-B	IL-1 alpha	18591(Tax:10090)	16175(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Intraglomerular expressions of IL-1_alpha and platelet-derived growth factor -LRB- PDGF-B -RRB- mRNA in experimental immune complex-mediated glomerulonephritis .
17144099	0	PDGF-B	50,56	IL-2	38,42	PDGF-B	IL-2	5155	3558	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
17144099	0	PDGF-B	50,56	IL-6	44,48	PDGF-B	IL-6	5155	3569	Gene	Gene	TGF-beta|appos|START_ENTITY TGF-beta|appos|END_ENTITY	-LSB- Gene expression of INF-gamma , IL-10 , IL-2 , IL-6 , PDGF-B i TGF-beta in kidney tissue after renal transplantation -RSB- .
11940383	0	PDGF-B	40,46	NF-kappaB	10,19	PDGF-B	NF-kappaB	5155	4790	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Effect of NF-kappaB on the induction of PDGF-B transcription by angiotensin_II in the ECV304 cell line .
7589454	0	PDGF-B	37,43	PKC_alpha	0,9	PDGF-B	PKC alpha	5155	5578	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PKC_alpha regulates thrombin-induced PDGF-B chain gene expression in mesangial cells .
2696512	0	PDGF-B	24,30	c-sis	32,37	PDGF-B	c-sis	24628(Tax:10116)	24628(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Increased expression of PDGF-B -LRB- c-sis -RRB- mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hyperoxia .
15582716	0	PDGF-B	93,99	galanin	75,82	PDGF-B	galanin	18591(Tax:10090)	14419(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY overexpressing|nmod|promoter overexpressing|dobj|END_ENTITY	Behavioural characterisation of young adult transgenic_mice overexpressing galanin under the PDGF-B promoter .
15944026	0	PDGF-B	81,87	galanin	63,70	PDGF-B	galanin	18591(Tax:10090)	14419(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Behavioural characterisation of transgenic_mice overexpressing galanin under the PDGF-B promoter .
8403516	0	PDGF-B	71,77	platelet-derived_growth_factor-B	37,69	PDGF-B	platelet-derived growth factor-B	5155	5155	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Up-regulation of alveolar macrophage platelet-derived_growth_factor-B -LRB- PDGF-B -RRB- mRNA by interferon-gamma from Mycobacterium tuberculosis antigen -LRB- PPD -RRB- - stimulated lymphocytes .
22912899	0	PDGF-B	14,20	syndecan-1	50,60	PDGF-B	syndecan-1	18591(Tax:10090)	20969(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase , Topors .
18925432	0	PDGF-C	59,65	platelet-derived_growth_factor-C	25,57	PDGF-C	platelet-derived growth factor-C	56034	56034	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The molecular cloning of platelet-derived_growth_factor-C -LRB- PDGF-C -RRB- gene of Gekko japonicus and its expression change in the spinal cord after tail amputation .
12149261	1	PDGF-r	164,170	LMW-PTP	147,154	PDGF-r	LMW-PTP	5159	52	Gene	Gene	activity|amod|START_ENTITY controls|dobj|activity controls|nsubj|END_ENTITY	LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation .
12149261	0	PDGF-r	128,134	platelet-derived_growth_factor_receptor	87,126	PDGF-r	platelet-derived growth factor receptor	5159	5159	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Insight into the role of low_molecular_weight_phosphotyrosine_phosphatase -LRB- LMW-PTP -RRB- on platelet-derived_growth_factor_receptor -LRB- PDGF-r -RRB- signaling .
22266848	0	PDGFA	15,20	MUC1	0,4	PDGFA	MUC1	5154	4582	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MUC1 regulates PDGFA expression during pancreatic_cancer progression .
23537647	0	PDGFB	34,39	Sp1	76,79	PDGFB	Sp1	5155	6667	Gene	Gene	START_ENTITY|acl|activating activating|dobj|END_ENTITY	The oncoprotein HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote the proliferation of breast_cancer cells .
2660925	0	PDGFB	36,41	c-sis	43,48	PDGFB	c-sis	5155	5155	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Translocation of c-abl oncogene and PDGFB -LRB- c-sis -RRB- gene in a case of CML with 46 , XY , t -LRB- 22 ; 22 -RRB- .
21789698	0	PDGFR	41,46	Platelet-derived_growth_factor_receptor	0,39	PDGFR	Platelet-derived growth factor receptor	5159	5159	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Platelet-derived_growth_factor_receptor -LRB- PDGFR -RRB- expression in primary spinal cord_gliomas .
21441409	0	PDGFR	132,137	VEGFR-1	84,91	PDGFR	VEGFR-1	18596(Tax:10090)	14254(Tax:10090)	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	Assessing the activity of cediranib , a VEGFR-2 / 3 tyrosine kinase inhibitor , against VEGFR-1 and members of the structurally related PDGFR family .
24243494	0	PDGFR	34,39	mToR	69,73	PDGFR	mToR	5159	21977(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Immunohistochemical expression of PDGFR , VEGF-C , and proteins of the mToR pathway before and after androgen_deprivation_therapy in prostate_carcinoma : significant decrease after treatment .
19690384	0	PDGFR	95,100	tenascin_C	84,94	PDGFR	tenascin C	18596(Tax:10090)	21923(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin_C / PDGFR pathway .
23160237	0	PDGFR-a	28,35	NG2	24,27	PDGFR-a	NG2	18595(Tax:10090)	121021(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Abnormal development of NG2 + PDGFR-a + neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model .
21729646	0	PDGFR-b	84,91	platelet-derived_growth_factor_receptor-beta	38,82	PDGFR-b	platelet-derived growth factor receptor-beta	5159	5159	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Immunohistochemical overexpression of platelet-derived_growth_factor_receptor-beta -LRB- PDGFR-b -RRB- is associated with PDGFRB gene copy number gain in sarcomatoid_non-small-cell_lung_cancer .
15944146	0	PDGFR-beta	46,56	Platelet-derived_growth_factor_receptor-beta	0,44	PDGFR-beta	Platelet-derived growth factor receptor-beta	5159	5159	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Platelet-derived_growth_factor_receptor-beta -LRB- PDGFR-beta -RRB- activation promotes its association with the low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- .
10691304	0	PDGFR-beta	106,116	VEGF	50,54	PDGFR-beta	VEGF	5159	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and platelet-derived_growth_factor_receptor-beta -LRB- PDGFR-beta -RRB- in human gliomas .
10458478	0	PDGFR-beta	206,216	beta_type_platelet-derived_growth_factor_receptor	155,204	PDGFR-beta	beta type platelet-derived growth factor receptor	24629(Tax:10116)	24629(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Better-surviving liver grafts by the injection of anti-CD2 antibody : the important roles of host CD8 + and CD2 + CD28 + T cells in chronic graft rejection and beta_type_platelet-derived_growth_factor_receptor -LRB- PDGFR-beta -RRB- expression on apoptotic liver grafts .
24489888	0	PDGFRA	85,91	ERK	40,43	PDGFRA	ERK	5156	5594	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA .
19035305	0	PDGFRA	22,28	KIT	155,158	PDGFRA	KIT	5156	3815	Gene	Gene	genes|compound|START_ENTITY analysis|nmod|genes leukaemias|nsubj|analysis leukaemias|nmod|mutation mutation|compound|END_ENTITY	Molecular analysis of PDGFRA and PDGFRB genes by rapid single-strand conformation polymorphism -LRB- SSCP -RRB- in patients with core-binding factor leukaemias with KIT or FLT3 mutation .
22355509	0	PDGFRA	124,130	KIT	74,77	PDGFRA	KIT	5156	3815	Gene	Gene	examination|appos|START_ENTITY examination|nmod|END_ENTITY	Malignant_melanoma of the nasal cavity : a case report with examination of KIT and platelet_derived_growth_factor_receptor-a -LRB- PDGFRA -RRB- .
25165019	0	PDGFRA	92,98	KIT	87,90	PDGFRA	KIT	5156	3815	Gene	Gene	SDH|appos|START_ENTITY SDH|compound|END_ENTITY	Quadruple wild-type -LRB- WT -RRB- GIST : defining the subset of GIST that lacks abnormalities of KIT , PDGFRA , SDH , or RAS signaling pathways .
26848617	0	PDGFRA	61,67	KIT	13,16	PDGFRA	KIT	5156	3815	Gene	Gene	mutations|dep|START_ENTITY mutational|dobj|mutations mutational|nsubj|END_ENTITY	Intratumoral KIT mutational heterogeneity and recurrent KIT / PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal_stromal_tumors .
26848617	0	PDGFRA	61,67	KIT	56,59	PDGFRA	KIT	5156	3815	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Intratumoral KIT mutational heterogeneity and recurrent KIT / PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal_stromal_tumors .
19246520	0	PDGFRA	0,6	PDGFRB	8,14	PDGFRA	PDGFRB	5156	5159	Gene	Gene	EGFR|compound|START_ENTITY EGFR|appos|END_ENTITY	PDGFRA , PDGFRB , EGFR , and downstream signaling activation in malignant_peripheral_nerve_sheath_tumor .
10850862	0	PDGFRA	64,70	platelet-derived_growth_factor_receptor-A	21,62	PDGFRA	platelet-derived growth factor receptor-A	5156	5156	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Amplification of the platelet-derived_growth_factor_receptor-A -LRB- PDGFRA -RRB- gene occurs in oligodendrogliomas with grade IV anaplastic features .
18686281	0	PDGFRA	100,106	platelet-derived_growth_factor_receptor_alpha	53,98	PDGFRA	platelet-derived growth factor receptor alpha	5156	5156	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inflammatory fibroid_polyps harbour mutations in the platelet-derived_growth_factor_receptor_alpha -LRB- PDGFRA -RRB- gene .
19246520	0	PDGFRB	8,14	PDGFRA	0,6	PDGFRB	PDGFRA	5159	5156	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	PDGFRA , PDGFRB , EGFR , and downstream signaling activation in malignant_peripheral_nerve_sheath_tumor .
12542482	0	PDGFRB	84,90	platelet-derived_growth_factor_receptor_beta	38,82	PDGFRB	platelet-derived growth factor receptor beta	5159	5159	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel translocations that disrupt the platelet-derived_growth_factor_receptor_beta -LRB- PDGFRB -RRB- gene in BCR-ABL-negative chronic_myeloproliferative_disorders .
18262053	0	PDGFRB	85,91	platelet-derived_growth_factor_receptor_beta	34,78	PDGFRB	platelet-derived growth factor receptor beta	5159	5159	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fusion of PRKG2 and SPTBN1 to the platelet-derived_growth_factor_receptor_beta gene -LRB- PDGFRB -RRB- in imatinib-responsive atypical myeloproliferative_disorders .
22293178	0	PDGFRa	42,48	SULF2	26,31	PDGFRa	SULF2	5156	55959	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant_glioma .
16804324	0	PDGFRalpha	77,87	platelet-derived_growth_factor_receptor-alpha	30,75	PDGFRalpha	platelet-derived growth factor receptor-alpha	5156	5156	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variant in promoter region of platelet-derived_growth_factor_receptor-alpha -LRB- PDGFRalpha -RRB- gene is associated with the severity and allergic status of childhood_asthma .
23382862	0	PDGFRb	23,29	P-Rex1	0,6	PDGFRb	P-Rex1	5159	57580	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	P-Rex1 cooperates with PDGFRb to drive cellular migration in 3D microenvironments .
23748876	0	PDGFRb	46,52	Platelet_derived_growth_factor_receptor-beta	0,44	PDGFRb	Platelet derived growth factor receptor-beta	5159	5159	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Platelet_derived_growth_factor_receptor-beta -LRB- PDGFRb -RRB- expression is limited to activated stromal cells in the bone marrow and shows a strong correlation with the grade of myelofibrosis .
24378362	0	PDGFRb	69,75	VCAM-1	47,53	PDGFRb	VCAM-1	5159	7412	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRb in a ligand-independent manner in mesenchymal stem cells .
24535964	0	PDGFRb	64,70	platelet_derived_growth_factor_receptor-beta	18,62	PDGFRb	platelet derived growth factor receptor-beta	5159	5159	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Image analysis of platelet_derived_growth_factor_receptor-beta -LRB- PDGFRb -RRB- expression to determine the grade and dynamics of myelofibrosis in bone marrow biopsy samples .
24810671	0	PDGFRb	64,70	platelet_derived_growth_factor_receptor-beta	18,62	PDGFRb	platelet derived growth factor receptor-beta	5159	5159	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Image analysis of platelet_derived_growth_factor_receptor-beta -LRB- PDGFRb -RRB- expression to determine the grade and dynamics of myelofibrosis in bone marrow biopsy samples .
16405759	0	PDGFRbeta	88,97	C-kit	32,37	PDGFRbeta	C-kit	5159	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression and significance of C-kit and platelet-derived_growth_factor_receptor-beta -LRB- PDGFRbeta -RRB- in esophageal_carcinoma -RSB- .
20484220	0	PDGFRbeta	25,34	CXCR4	16,21	PDGFRbeta	CXCR4	18596(Tax:10090)	12767(Tax:10090)	Gene	Gene	Contribution|dep|START_ENTITY Contribution|nmod|END_ENTITY	Contribution of CXCR4 -LRB- + -RRB- / PDGFRbeta -LRB- + -RRB- progenitor cells in hypoxic_alveolar_arterioles muscularization : role of myocardin .
19426150	0	PDGFRbeta	7,16	VEGFR2	0,6	PDGFRbeta	VEGFR2	5159	3791	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	VEGFR2 + PDGFRbeta + circulating precursor cells participate in capillary restoration after hyperoxia_acute_lung_injury -LRB- HALI -RRB- .
20484220	0	PDGFRbeta	25,34	myocardin	111,120	PDGFRbeta	myocardin	18596(Tax:10090)	214384(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Contribution of CXCR4 -LRB- + -RRB- / PDGFRbeta -LRB- + -RRB- progenitor cells in hypoxic_alveolar_arterioles muscularization : role of myocardin .
2067847	0	PDGF_B	70,76	c-sis	77,82	PDGF B	c-sis	5155	5155	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	5 ' untranslated sequences determine degradative pathway for alternate PDGF_B / c-sis mRNA 's .
20637211	0	PDH	88,91	pigment-dispersing_hormone	60,86	PDH	pigment-dispersing hormone	43193(Tax:7227)	43193(Tax:7227)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Precursor structure , distribution and possible functions of pigment-dispersing_hormone -LRB- PDH -RRB- in the terrestrial isopod Armadillidium vulgare -LRB- Latreille -RRB- .
11991544	0	PDH	38,41	pyruvate_dehydrogenase	14,36	PDH	pyruvate dehydrogenase	54704	54704	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regulation of pyruvate_dehydrogenase -LRB- PDH -RRB- activity in human skeletal muscle during exercise .
8936413	0	PDH	77,80	pyruvate_dehydrogenase	44,66	PDH	pyruvate dehydrogenase	54704	54704	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Effect of duration of cerebral_ischemia on pyruvate_dehydrogenase activity -LRB- PDH -RRB- and metabolites in the gerbil brain -RSB- .
10542321	0	PDHA-2	121,127	pyruvate_dehydrogenase_alpha-subunit	83,119	PDHA-2	pyruvate dehydrogenase alpha-subunit	5161	5161	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the regulatory region of the human testis-specific form of the pyruvate_dehydrogenase_alpha-subunit -LRB- PDHA-2 -RRB- gene .
23376309	0	PDI	55,58	protein_disulfide_isomerase	26,53	PDI	protein disulfide isomerase	64714	64714	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of radiolabeled protein_disulfide_isomerase -LRB- PDI -RRB- inhibitors as new potential PET agents for imaging of the enzyme PDI in neurological_disorders and cancer .
8188714	0	PDI	42,45	protein_disulfide_isomerase	13,40	PDI	protein disulfide isomerase	64714	64714	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of protein_disulfide_isomerase -LRB- PDI -RRB- on antibody folding in vitro .
19747560	0	PDIA3	71,76	protein_disulfide_isomerase_associated_3	29,69	PDIA3	protein disulfide isomerase associated 3	100316863(Tax:8030)	100316863(Tax:8030)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Stress-induced expression of protein_disulfide_isomerase_associated_3 -LRB- PDIA3 -RRB- in Atlantic_salmon -LRB- Salmo_salar L. -RRB- .
24636989	0	PDIA5	99,104	ATF6a	60,65	PDIA5	ATF6a	10954	22926	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Endoplasmic reticulum stress-activated transcription factor ATF6a requires the disulfide isomerase PDIA5 to modulate chemoresistance .
26947243	0	PDIA6	20,25	proinsulin	53,63	PDIA6	proinsulin	10130	3630	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A prominent role of PDIA6 in processing of misfolded proinsulin .
14604990	0	PDK-1	143,148	cytokine-independent_survival_kinase	93,129	PDK-1	cytokine-independent survival kinase	5163	23678	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell : cytokine-independent_survival_kinase -LRB- CISK -RRB- binds PDK-1 in vivo in a phosphorylation-dependent manner .
18802401	0	PDK1	74,78	3-phosphoinositide-dependent_protein_kinase-1	27,72	PDK1	3-phosphoinositide-dependent protein kinase-1	18607(Tax:10090)	18607(Tax:10090)	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Dissecting the role of the 3-phosphoinositide-dependent_protein_kinase-1 -LRB- PDK1 -RRB- signalling pathways .
20200230	0	PDK1	120,124	AKT	59,62	PDK1	AKT	5163	207	Gene	Gene	functions|nmod|START_ENTITY requires|dobj|functions requires|nsubj|END_ENTITY	Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2 .
20643654	0	PDK1	0,4	AKT	98,101	PDK1	AKT	5163	207	Gene	Gene	recruitment|compound|START_ENTITY enhances|nsubj|recruitment enhances|dobj|activation activation|compound|END_ENTITY	PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like_growth_factor-i-stimulated AKT activation and vascular smooth muscle cell survival .
11278269	0	PDK1	74,78	Akt	20,23	PDK1	Akt	5163	207	Gene	Gene	localization|nmod|START_ENTITY blocking|dobj|localization inhibits|advcl|blocking inhibits|dobj|activity activity|compound|END_ENTITY	Cyclic_AMP inhibits Akt activity by blocking the membrane localization of PDK1 .
11752451	0	PDK1	0,4	Akt	30,33	PDK1	Akt	38017(Tax:7227)	41957(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	PDK1 regulates growth through Akt and S6K in Drosophila .
18347057	0	PDK1	16,20	Akt	57,60	PDK1	Akt	228026(Tax:10090)	11651(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY Mutation|nmod|domain inhibits|nsubj|Mutation inhibits|dobj|END_ENTITY	Mutation of the PDK1 PH domain inhibits protein_kinase_B / Akt , leading to small size and insulin resistance .
19065678	0	PDK1	105,109	Akt	111,114	PDK1	Akt	228026(Tax:10090)	11651(Tax:10090)	Gene	Gene	phosphoinositide-dependent_protein_kinase_1|dep|START_ENTITY phosphoinositide-dependent_protein_kinase_1|dep|modulate modulate|nsubj|END_ENTITY	The survival pathways phosphatidylinositol-3_kinase -LRB- PI3-K -RRB- / phosphoinositide-dependent_protein_kinase_1 -LRB- PDK1 -RRB- / Akt modulate liver_regeneration through hepatocyte size rather than proliferation .
21906027	0	PDK1	80,84	Akt	104,107	PDK1	Akt	228026(Tax:10090)	11651(Tax:10090)	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	S6K inhibition renders cardiac protection against myocardial_infarction through PDK1 phosphorylation of Akt .
22177954	0	PDK1	70,74	Akt	39,42	PDK1	Akt	5163	207	Gene	Gene	kinase|compound|START_ENTITY affecting|dobj|kinase inhibits|advcl|affecting inhibits|dobj|activity activity|compound|END_ENTITY	Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells .
22837796	0	PDK1	8,12	Akt	95,98	PDK1	Akt	116551(Tax:10116)	24185(Tax:10116)	Gene	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|apoptosis apoptosis|advcl|activating activating|dobj|signaling signaling|compound|END_ENTITY	Induced PDK1 kinase activity suppresses apoptosis in intestinal epithelial cells by activating Akt signaling following polyamine depletion .
23030823	0	PDK1	110,114	Akt	0,3	PDK1	Akt	5163	207	Gene	Gene	inhibitors|nummod|START_ENTITY leading|nmod|inhibitors mechanisms|acl|leading mechanisms|nsubj|END_ENTITY	Akt is efficiently activated by PIF-pocket - and PtdIns -LRB- 3,4,5 -RRB- P3-dependent mechanisms leading to resistance to PDK1 inhibitors .
24352480	0	PDK1	0,4	Akt	44,47	PDK1	Akt	5163	207	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|nmod|END_ENTITY	PDK1 selectively phosphorylates Thr -LRB- 308 -RRB- on Akt and contributes to human platelet functional responses .
26553931	0	PDK1	35,39	Akt	85,88	PDK1	Akt	228026(Tax:10090)	11651(Tax:10090)	Gene	Gene	anchor|nmod|START_ENTITY AMIGO2|appos|anchor controls|nsubj|AMIGO2 controls|dobj|survival survival|nmod|activation activation|compound|END_ENTITY	AMIGO2 , a novel membrane anchor of PDK1 , controls cell survival and angiogenesis via Akt activation .
24516643	0	PDK1	99,103	Akt1	91,95	PDK1	Akt1	5163	207	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
24516643	0	PDK1	99,103	GRP78	51,56	PDK1	GRP78	5163	3309	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
26318166	0	PDK1	0,4	JunB	13,17	PDK1	JunB	5163	3726	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PDK1 induces JunB , EMT , cell migration and invasion in human gallbladder_cancer .
23893244	0	PDK1	0,4	PI3K	23,27	PDK1	PI3K	5163	5293	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	PDK1 controls upstream PI3K expression and PIP3 generation .
16601102	0	PDK1	125,129	PINOID	34,40	PDK1	PINOID	830330(Tax:3702)	818030(Tax:3702)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of PINOID by the phospholipid_signaling_kinase_3-phosphoinositide-dependent_protein_kinase_1 -LRB- PDK1 -RRB- in Arabidopsis .
25742010	0	PDK1	36,40	PKC	0,3	PDK1	PKC	5163	112476	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	PKC / Rdx-driven Phosphorylation of PDK1 : A Novel Mechanism Promoting Cancer Cell Survival and Permissiveness for Parvovirus-induced Lysis .
19047061	0	PDK1	63,67	Protein_kinase_C_theta	0,22	PDK1	Protein kinase C theta	228026(Tax:10090)	18761(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Protein_kinase_C_theta -LRB- PKCtheta -RRB- - dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance .
15187024	0	PDK1	82,86	Puromycin-insensitive_leucyl-specific_aminopeptidase	0,52	PDK1	Puromycin-insensitive leucyl-specific aminopeptidase	5163	51752	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Puromycin-insensitive_leucyl-specific_aminopeptidase -LRB- PILSAP -RRB- binds and catalyzes PDK1 , allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis .
14585963	0	PDK1	52,56	Pyk2	0,4	PDK1	Pyk2	5163	2185	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Pyk2 - and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions .
11889038	0	PDK1	0,4	Ral-GEF	36,43	PDK1	Ral-GEF	5163	5900	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism .
24516643	0	PDK1	99,103	Raptor	124,130	PDK1	Raptor	5163	57521	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
20643654	0	PDK1	0,4	SHPS-1	24,30	PDK1	SHPS-1	5163	140885	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like_growth_factor-i-stimulated AKT activation and vascular smooth muscle cell survival .
23183047	0	PDK1	0,4	mTOR	19,23	PDK1	mTOR	5163	21977(Tax:10090)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	PDK1 regulation of mTOR and hypoxia-inducible_factor_1 integrate metabolism and migration of CD8 + T cells .
9445476	0	PDK1	44,48	p70s6k	34,40	PDK1	p70s6k	5163	6198	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of p70s6k by PDK1 .
17531483	0	PDK1	54,58	phosphoinositide-dependent_kinase-1	17,52	PDK1	phosphoinositide-dependent kinase-1	5163	5163	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Indolinone based phosphoinositide-dependent_kinase-1 -LRB- PDK1 -RRB- inhibitors .
17544272	0	PDK1	54,58	phosphoinositide-dependent_kinase-1	17,52	PDK1	phosphoinositide-dependent kinase-1	5163	5163	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Indolinone based phosphoinositide-dependent_kinase-1 -LRB- PDK1 -RRB- inhibitors .
24395567	0	PDK1	85,89	pyruvate_dehydrogenase_kinase_1	52,83	PDK1	pyruvate dehydrogenase kinase 1	116551(Tax:10116)	116551(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Resveratrol restores sirtuin_1 -LRB- SIRT1 -RRB- activity and pyruvate_dehydrogenase_kinase_1 -LRB- PDK1 -RRB- expression after hemorrhagic_injury in a rat model .
23297365	0	PDK3	143,147	pyruvate_dehydrogenase_kinase_isoenzyme_3	100,141	PDK3	pyruvate dehydrogenase kinase isoenzyme 3	5165	5165	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new locus for X-linked dominant Charcot-Marie-Tooth_disease -LRB- CMTX6 -RRB- is caused by mutations in the pyruvate_dehydrogenase_kinase_isoenzyme_3 -LRB- PDK3 -RRB- gene .
16314495	0	PDK4	23,27	ERRalpha	76,84	PDK4	ERRalpha	5166	2101	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha : a mechanism for transcriptional control of muscle glucose metabolism .
16623704	0	PDK4	85,89	ERRalpha	18,26	PDK4	ERRalpha	5166	2101	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression PGC-1alpha|nmod|activation partner|nmod|PGC-1alpha Identification|nmod|partner Identification|nmod|END_ENTITY	Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle .
26740179	0	PDK4	56,60	JNK	104,107	PDK4	JNK	27273(Tax:10090)	26419(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Inflammation increases pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- expression via the Jun N-Terminal Kinase -LRB- JNK -RRB- pathway in C2C12 cells .
16314495	0	PDK4	23,27	PGC-1alpha	0,10	PDK4	PGC-1alpha	5166	10891	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha : a mechanism for transcriptional control of muscle glucose metabolism .
16623704	0	PDK4	85,89	PGC-1alpha	52,62	PDK4	PGC-1alpha	5166	10891	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression END_ENTITY|nmod|activation	Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle .
25609694	0	PDK4	16,20	ZBTB2	0,5	PDK4	ZBTB2	27273(Tax:10090)	381990(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65 .
16757381	0	PDK4	120,124	pyruvate_dehydrogenase_kinase_4	87,118	PDK4	pyruvate dehydrogenase kinase 4	5166	5166	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Retinoic_acids and trichostatin_A -LRB- TSA -RRB- , a histone deacetylase inhibitor , induce human pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- gene expression .
21586575	0	PDK4	47,51	pyruvate_dehydrogenase_kinase_4	14,45	PDK4	pyruvate dehydrogenase kinase 4	89813(Tax:10116)	89813(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- by CCAAT/enhancer-binding _ protein_beta -LRB- C/EBPbeta -RRB- .
26740179	0	PDK4	56,60	pyruvate_dehydrogenase_kinase_4	23,54	PDK4	pyruvate dehydrogenase kinase 4	27273(Tax:10090)	27273(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inflammation increases pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- expression via the Jun N-Terminal Kinase -LRB- JNK -RRB- pathway in C2C12 cells .
11857447	0	PDL	99,102	c-Fos	60,65	PDL	c-Fos	5133	2353	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Effect of protein kinase inhibitors on the stretch-elicited c-Fos and c-Jun up-regulation in human PDL osteoblast-like cells .
26408698	0	PDL1	29,33	Programmed_Death-1_Ligand-1	0,27	PDL1	Programmed Death-1 Ligand-1	29126	29126	Gene	Gene	Expression|appos|START_ENTITY Expression|amod|END_ENTITY	Programmed_Death-1_Ligand-1 -LRB- PDL1 -RRB- Expression Is Associated with the Prognosis of Patients with Stage_II / III_Gastric_Cancer .
26577528	0	PDL1	0,4	p53	19,22	PDL1	p53	60533(Tax:10090)	22060(Tax:10090)	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	PDL1 Regulation by p53 via miR-34 .
18811584	0	PDL2	149,153	CCL27	111,116	PDL2	CCL27	80380	10850	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PDL2	149,153	CCR4	125,129	PDL2	CCR4	80380	1233	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PDL2	149,153	CCR5	131,135	PDL2	CCR5	80380	1234	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PDL2	149,153	CXCR3	137,142	PDL2	CXCR3	80380	2833	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PDL2	149,153	IFN-beta	161,169	PDL2	IFN-beta	80380	3456	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PDL2	149,153	IP-10	118,123	PDL2	IP-10	80380	3627	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PDL2	149,153	MIP-1alpha	99,109	PDL2	MIP-1alpha	80380	6348	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
18811584	0	PDL2	149,153	PD1	144,147	PDL2	PD1	80380	6622	Gene	Gene	TIM1|appos|START_ENTITY TIM1|appos|END_ENTITY	Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22 , MIP-1alpha , CCL27 , IP-10 , CCR4 , CCR5 , CXCR3 , PD1 , PDL2 , IL-3 , IFN-beta , TIM1 , and TLR2 but low antigen-specific cellular responses .
22731402	0	PDLIM2	0,6	Th1	17,20	PDLIM2	Th1	64236	51497	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|END_ENTITY	PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune_disease .
16044170	0	PDLIM5	49,55	LIM	44,47	PDLIM5	LIM	10611	10611	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression and association analyses of LIM -LRB- PDLIM5 -RRB- in bipolar_disorder and schizophrenia .
16595163	0	PDLIM5	49,55	LIM	44,47	PDLIM5	LIM	10611	10611	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression and association analysis of LIM -LRB- PDLIM5 -RRB- in major_depression .
25524223	0	PDLIM5	0,6	PKC	16,19	PDLIM5	PKC	10611	5581	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|translocation translocation|compound|END_ENTITY	PDLIM5 mediates PKC translocation in PMA-induced growth cone collapse .
26556890	0	PDLIM7	0,6	Nedd4-1	49,56	PDLIM7	Nedd4-1	67399(Tax:10090)	17999(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle .
19184109	0	PDP1	38,42	Pyruvate_dehydrogenase_phosphatase_1	0,36	PDP1	Pyruvate dehydrogenase phosphatase 1	54704	54704	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Pyruvate_dehydrogenase_phosphatase_1 -LRB- PDP1 -RRB- null mutation produces a lethal infantile phenotype .
9428726	0	PDR10	51,56	Pdr1	93,97	PDR10	Pdr1	854506(Tax:4932)	852871(Tax:4932)	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	The yeast ATP binding cassette -LRB- ABC -RRB- protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators .
15294907	0	PDR5	57,61	Pdr1	33,37	PDR5	Pdr1	854324(Tax:4932)	852871(Tax:4932)	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces_cerevisiae : evidence for enhanced recruitment of coactivators and altered nucleosome structures .
14508505	0	PDS	32,35	SLC26A4	37,44	PDS	SLC26A4	5172	5172	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Distribution and frequencies of PDS -LRB- SLC26A4 -RRB- mutations in Pendred_syndrome and nonsyndromic_hearing_loss associated with enlarged_vestibular_aqueduct : a unique spectrum of mutations in Japanese .
14560015	0	PDS-5	30,35	EVL-14	23,29	PDS-5	EVL-14	855099(Tax:4932)	175555(Tax:6239)	Gene	Gene	essential|nsubj|START_ENTITY END_ENTITY|parataxis|essential	Caenorhabditis_elegans EVL-14 / PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis .
21821004	0	PDX-1	15,20	ATF3	0,4	PDX-1	ATF3	18609(Tax:10090)	11910(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	ATF3 represses PDX-1 expression in pancreatic b-cells .
21385937	0	PDX-1	22,27	FoxA2	52,57	PDX-1	FoxA2	3651	3170	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic_b-cells_dysfunction .
17192469	0	PDX-1	73,78	Peroxisome_proliferator-activated_receptor-gamma	0,48	PDX-1	Peroxisome proliferator-activated receptor-gamma	29535(Tax:10116)	25664(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma regulates expression of PDX-1 and NKX6 .1 in INS-1 cells .
15793239	0	PDX-1	0,5	VP16	6,10	PDX-1	VP16	3651	3054	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|END_ENTITY	PDX-1 / VP16 fusion protein , together with NeuroD or Ngn3 , markedly induces insulin gene transcription and ameliorates glucose tolerance .
15486225	0	PDX-1	114,119	glucose-dependent-insulinotropic_polypeptide	28,72	PDX-1	glucose-dependent-insulinotropic polypeptide	18609(Tax:10090)	14607(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Cell-specific expression of glucose-dependent-insulinotropic_polypeptide is regulated by the transcription factor PDX-1 .
10390156	0	PDX-1	92,97	insulin	18,25	PDX-1	insulin	3651	3630	Gene	Gene	domain|compound|START_ENTITY potency|nmod|domain stimulation|nmod|potency Regulation|dep|stimulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the insulin gene by glucose : stimulation of trans-activation potency of human PDX-1 N-terminal domain .
10426567	0	PDX-1	209,214	insulin	101,108	PDX-1	insulin	3651	3630	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|protein_kinase_C protein_kinase_C|nmod|expression expression|nmod|gene gene|compound|END_ENTITY	Possible involvement of atypical protein_kinase_C -LRB- PKC -RRB- in glucose-sensitive expression of the human insulin gene : DNA-binding activity and transcriptional activity of pancreatic_and_duodenal_homeobox_gene-1 -LRB- PDX-1 -RRB- are enhanced via calphostin_C-sensitive but phorbol_12-myristate_13-acetate -LRB- PMA -RRB- and G 6976-insensitive pathway .
10868963	0	PDX-1	79,84	insulin	22,29	PDX-1	insulin	3651	3630	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|modulation modulation|nmod|levels levels|compound|END_ENTITY	Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2 + .
15028719	0	PDX-1	26,31	insulin	58,65	PDX-1	insulin	3651	3630	Gene	Gene	site|compound|START_ENTITY Identification|nmod|site Identification|nmod|enhancer enhancer|compound|END_ENTITY	Identification of a novel PDX-1 binding site in the human insulin gene enhancer .
15793239	0	PDX-1	0,5	insulin	74,81	PDX-1	insulin	3651	3630	Gene	Gene	START_ENTITY|appos|induces induces|dobj|transcription transcription|compound|END_ENTITY	PDX-1 / VP16 fusion protein , together with NeuroD or Ngn3 , markedly induces insulin gene transcription and ameliorates glucose tolerance .
15862113	0	PDX-1	25,30	insulin	82,89	PDX-1	insulin	3651	3630	Gene	Gene	contribution|nmod|START_ENTITY contribution|nmod|regulation regulation|nmod|promoter promoter|compound|END_ENTITY	Relative contribution of PDX-1 , MafA and E47/beta2 to the regulation of the human insulin promoter .
16461554	0	PDX-1	15,20	insulin	44,51	PDX-1	insulin	3651	3630	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|transcription transcription|compound|END_ENTITY	Involvement of PDX-1 in activation of human insulin gene transcription .
22790351	0	PDX-1	92,97	insulin	24,31	PDX-1	insulin	3651	3630	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver_cirrhosis : a comparative investigation using human autopsy specimens .
23703573	0	PDX-1	101,106	insulin	66,73	PDX-1	insulin	3651	3630	Gene	Gene	induction|nmod|START_ENTITY secretion|nmod|induction secretion|compound|END_ENTITY	B-cell_translocation_gene_2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic b-cells .
8922372	0	PDX-1	0,5	insulin	14,21	PDX-1	insulin	3651	3630	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expressions expressions|compound|END_ENTITY	PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin .
9312185	0	PDX-1	36,41	insulin	81,88	PDX-1	insulin	3651	3630	Gene	Gene	Suppression|nmod|START_ENTITY -1|dep|Suppression -1|parataxis|causes causes|dobj|decrease decrease|nmod|mRNA mRNA|compound|END_ENTITY	Suppression of transcription factor PDX-1 / IPF1/STF -1 / IDX-1 causes no decrease in insulin mRNA in MIN6 cells .
21804373	0	PDX1	59,63	Epidermal_Growth_Factor	20,43	PDX1	Epidermal Growth Factor	29535(Tax:10116)	25313(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Effects|nmod|Expression Effects|nmod|END_ENTITY	Effects of Combined Epidermal_Growth_Factor and Gastrin on PDX1 Expression in Experimental Type 1 Diabetic Rats .
22270267	0	PDX1	39,43	Epidermal_growth_factor	0,23	PDX1	Epidermal growth factor	29535(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Epidermal_growth_factor and gastrin on PDX1 expression in experimental type 1 diabetic rats .
22640736	0	PDX1	0,4	FABP1	19,24	PDX1	FABP1	3651	2168	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells .
20637728	0	PDX1	36,40	Pancreatic_and_duodenal_homeobox_1	0,34	PDX1	Pancreatic and duodenal homeobox 1	18609(Tax:10090)	18609(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Pancreatic_and_duodenal_homeobox_1 -LRB- PDX1 -RRB- phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization .
25220237	0	PDYN	0,4	REST	66,70	PDYN	REST	5173	5978	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	PDYN , a gene implicated in brain/mental _ disorders , is targeted by REST in the adult human brain .
19468819	0	PDYN	36,40	prodynorphin	22,34	PDYN	prodynorphin	5173	5173	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Gene polymorphisms in prodynorphin -LRB- PDYN -RRB- are associated with episodic memory in the elderly .
25048760	0	PDYN	74,78	prodynorphin	60,72	PDYN	prodynorphin	5173	5173	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between VNTR polymorphism in promoter region of prodynorphin -LRB- PDYN -RRB- gene and heroin_dependence .
22275068	0	PDZ	56,59	PICK1	70,75	PDZ	PICK1	7082	9463	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The binding affinities of proteins interacting with the PDZ domain of PICK1 .
12370312	0	PDZ-GEF	11,18	Rap1_GTPase	61,72	PDZ-GEF	Rap1 GTPase	33881(Tax:7227)	38244(Tax:7227)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Drosophila PDZ-GEF , a guanine_nucleotide exchange factor for Rap1_GTPase , reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway .
16171862	0	PDZ-binding_kinase	14,32	PBK	34,37	PDZ-binding kinase	PBK	55872	55872	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of PDZ-binding_kinase -LRB- PBK -RRB- is regulated by cell cycle-specific transcription factors E2F and CREB/ATF .
16980545	0	PDZ-protein	25,36	GluR1	53,58	PDZ-protein	GluR1	10207	2890	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity .
15523054	0	PDZK1	0,5	OCTN2	78,83	PDZK1	OCTN2	5174	6584	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2 .
24115750	0	PDZK1	17,22	Oatp1a1	0,7	PDZK1	Oatp1a1	59020(Tax:10090)	28248(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Oatp1a1 requires PDZK1 to traffic to the plasma membrane by selective recruitment of microtubule-based motor proteins .
22528496	0	PDZK1	25,30	PDZ_domain-containing_1	0,23	PDZK1	PDZ domain-containing 1	5174	5174	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	PDZ_domain-containing_1 -LRB- PDZK1 -RRB- protein regulates phospholipase_C-b3 -LRB- PLC-b3 -RRB- - specific activation of somatostatin by forming a ternary complex with PLC-b3 and somatostatin receptors .
16738539	0	PDZK1	23,28	PEPT2	70,75	PDZK1	PEPT2	5174	6565	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity .
15304510	0	PDZK1	46,51	URAT1	112,117	PDZK1	URAT1	5174	116085	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus .
21816982	0	PDZK1	0,5	breast_cancer_resistance_protein	16,48	PDZK1	breast cancer resistance protein	59020(Tax:10090)	26357(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PDZK1 regulates breast_cancer_resistance_protein in small intestine .
10496535	0	PDZK1	0,5	cMOAT	118,123	PDZK1	cMOAT	5174	1244	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PDZK1 , a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21 , interacts with cMOAT -LRB- MRP2 -RRB- , the multidrug_resistance-associated_protein .
18955051	0	PDZK1	24,29	peroxisome_proliferator-activated_receptor_alpha	44,92	PDZK1	peroxisome proliferator-activated receptor alpha	5174	5465	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of the human PDZK1 expression by peroxisome_proliferator-activated_receptor_alpha .
16896066	0	PDZK2	20,25	OCTN2	96,101	PDZK2	OCTN2	79849	6584	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	PDZ adaptor protein PDZK2 stimulates transport activity of organic cation/carnitine transporter OCTN2 by modulating cell surface expression .
18940608	0	PDZRhoGEF	71,80	Galpha13	39,47	PDZRhoGEF	Galpha13	9826;9181	10672	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of the activated states of Galpha13 by the rgRGS domain of PDZRhoGEF .
15530360	0	PDZRhoGEF	68,77	RhoA	25,29	PDZRhoGEF	RhoA	9826;9181	387	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF , an activator of the Ca -LRB- 2 + -RRB- sensitization pathway in smooth muscle .
22528496	0	PDZ_domain-containing_1	0,23	PDZK1	25,30	PDZ domain-containing 1	PDZK1	5174	5174	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	PDZ_domain-containing_1 -LRB- PDZK1 -RRB- protein regulates phospholipase_C-b3 -LRB- PLC-b3 -RRB- - specific activation of somatostatin by forming a ternary complex with PLC-b3 and somatostatin receptors .
9192842	0	PE-2	72,76	ERF	78,81	PE-2	ERF	2077	2077	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Genomic structure and chromosomal localization of the novel ETS factor , PE-2 -LRB- ERF -RRB- .
21736557	0	PEA3	41,45	CoAA	26,30	PEA3	CoAA	2118	10432	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The coactivator_activator CoAA regulates PEA3 group member transcriptional activity .
12372284	0	PEA3	18,22	GDNF	0,4	PEA3	GDNF	2118	2668	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	GDNF acts through PEA3 to regulate cell body positioning and muscle innervation of specific motor neuron pools .
23581225	0	PEA3	51,55	HER2	26,30	PEA3	HER2	2118	2064	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Simvastatin downregulates HER2 via upregulation of PEA3 to induce cell death in HER2-positive breast_cancer cells .
21679465	0	PEA3	46,50	NOTCH-1	0,7	PEA3	NOTCH-1	2118	4851	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast_cancer : novel therapeutic implications .
24983502	0	PEA3	67,71	OCT4	30,34	PEA3	OCT4	2118	5460	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic_carcinoma cells .
19129951	0	PEA3	0,4	VEGF	15,19	PEA3	VEGF	2118	7422	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	PEA3 activates VEGF transcription in T47D and SKBR3 breast_cancer cells .
16786139	0	PEA3	0,4	c-Jun	21,26	PEA3	c-Jun	2118	3725	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	PEA3 cooperates with c-Jun in regulation of HER2/neu transcription .
7559555	0	PEA3	7,11	c-Jun	71,76	PEA3	c-Jun	2118	3725	Gene	Gene	subfamily|compound|START_ENTITY ERM|appos|subfamily cooperate|nsubj|ERM cooperate|nmod|END_ENTITY	ERM , a PEA3 subfamily of Ets transcription factors , can cooperate with c-Jun .
21529916	0	PEBP1	29,34	CCT8	23,27	PEBP1	CCT8	618233(Tax:9913)	281047(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	Association of CRISP2 , CCT8 , PEBP1 mRNA abundance in sperm and sire_conception_rate in Holstein bulls .
21529916	0	PEBP1	29,34	CRISP2	15,21	PEBP1	CRISP2	618233(Tax:9913)	512443(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Association of CRISP2 , CCT8 , PEBP1 mRNA abundance in sperm and sire_conception_rate in Holstein bulls .
25721211	0	PEBP4	67,72	miR-15b	0,7	PEBP4	miR-15b	157310	406949	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung_adenocarcinoma cells .
9066919	0	PECAM	61,66	platelet-endothelial_cell_adhesion_molecule-1	14,59	PECAM	platelet-endothelial cell adhesion molecule-1	5175	5175	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM -RRB- by macaque trophoblast cells during invasion of the spiral arteries .
16118242	0	PECAM-1	8,15	Akt	58,61	PECAM-1	Akt	5175	207	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in endothelial cells .
10213905	0	PECAM-1	14,21	CD31	23,27	PECAM-1	CD31	5175	5175	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Modulation of PECAM-1 -LRB- CD31 -RRB- expression in human endothelial cells : effect of IFNgamma and IL-10 .
17510564	0	PECAM-1	20,27	CD31	14,18	PECAM-1	CD31	5175	5175	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Evaluation of CD31 -LRB- PECAM-1 -RRB- expression using tissue microarray in patients with renal_cell_carcinoma .
18523558	0	PECAM-1	17,24	CD31	26,30	PECAM-1	CD31	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for PECAM-1 -LRB- CD31 -RRB- in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow .
9284815	0	PECAM-1	27,34	CD31	35,39	PECAM-1	CD31	29583(Tax:10116)	29583(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of endothelial PECAM-1 / CD31 in angiogenesis .
9575861	0	PECAM-1	8,15	CD31	17,21	PECAM-1	CD31	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of PECAM-1 -LRB- CD31 -RRB- in neutrophil transmigration in murine models of liver_and_peritoneal_inflammation .
22552856	0	PECAM-1	109,116	SDF-1	103,108	PECAM-1	SDF-1	5175	6387	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Umbilical cord blood-derived stromal cells regulate megakaryocytic proliferation and migration through SDF-1 / PECAM-1 pathway .
12646189	0	PECAM-1	0,7	beta-catenin	17,29	PECAM-1	beta-catenin	5175	1499	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|amod|END_ENTITY	PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation .
12850829	0	PECAM-1	31,38	moesin	9,15	PECAM-1	moesin	5175	4478	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Platelet moesin interacts with PECAM-1 -LRB- CD31 -RRB- .
11795274	0	PECAM-1	68,75	platelet-endothelial_cell_adhesion_molecule-1	21,66	PECAM-1	platelet-endothelial cell adhesion molecule-1	5175	5175	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- gene , Asn563Ser and Gly670Arg , associated with myocardial_infarction in the Japanese .
17607964	0	PECAM-1	142,149	platelet-endothelial_cell_adhesion_molecule-1	95,140	PECAM-1	platelet-endothelial cell adhesion molecule-1	5175	5175	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
7507944	0	PECAM-1	61,68	platelet-endothelial_cell_adhesion_molecule-1	14,59	PECAM-1	platelet-endothelial cell adhesion molecule-1	5175	5175	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- during melanoma-induced angiogenesis in vivo .
9789258	0	PECAM-1	74,81	platelet-endothelial_cell_adhesion_molecule-1	27,72	PECAM-1	platelet-endothelial cell adhesion molecule-1	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- in murine tissues .
14688220	0	PECAM-1	77,84	platelet_endothelial_cell_adhesion_molecule	32,75	PECAM-1	platelet endothelial cell adhesion molecule	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of platelet_endothelial_cell_adhesion_molecule -LRB- PECAM-1 , CD31 -RRB- in vascular endothelium .
9084985	0	PECAM-1	75,82	platelet_endothelial_cell_adhesion_molecule-1	28,73	PECAM-1	platelet endothelial cell adhesion molecule-1	282303(Tax:9913)	282303(Tax:9913)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- in mechanically stimulated vascular endothelial cells .
26706435	0	PECAM1	0,6	Gab1	31,35	PECAM1	Gab1	18613(Tax:10090)	14388(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling .
21723278	0	PECAM1	174,180	Tie-2	120,125	PECAM1	Tie-2	18613(Tax:10090)	21687(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Angiopoietins-1_and _ -2 play opposing roles in endothelial sprouting of embryoid bodies in 3D culture and their receptor Tie-2 associates with the cell-cell adhesion molecule PECAM1 .
12599204	0	PEDF	24,28	EPC-1	18,23	PEDF	EPC-1	5176	80314	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Putative role for EPC-1 / PEDF in the G0 growth_arrest of human diploid fibroblasts .
15140209	0	PEDF	14,18	EPC-1	8,13	PEDF	EPC-1	5176	80314	Gene	Gene	expression|amod|START_ENTITY Loss|dep|expression Loss|nmod|END_ENTITY	Loss of EPC-1 / PEDF expression during skin aging in vivo .
23548673	0	PEDF	46,50	MT1-MMP	14,21	PEDF	MT1-MMP	57104	4323	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MT1-MMP and MMP-2 by the serpin PEDF : a promising new target for metastatic_cancer .
22115973	0	PEDF	60,64	Microphthalmia-associated_transcription_factor	0,46	PEDF	Microphthalmia-associated transcription factor	5176	4286	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Microphthalmia-associated_transcription_factor acts through PEDF to regulate RPE cell migration .
19211999	0	PEDF	11,15	PACAP	28,33	PEDF	PACAP	287526(Tax:10116)	24166(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of PEDF and VEGF on PACAP - / VIP-induced cAMP formation in rat brain derived astrocyte cultures .
23818523	0	PEDF	73,77	PEDF-R	88,94	PEDF	PEDF-R	57104	57104	Gene	Gene	Receptor|compound|START_ENTITY Receptor|appos|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- prevents retinal cell death via PEDF Receptor -LRB- PEDF-R -RRB- : identification of a functional ligand binding site .
17651710	0	PEDF	0,4	PPAR_gamma	44,54	PEDF	PPAR gamma	5176	5468	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	PEDF induces p53-mediated apoptosis through PPAR_gamma signaling in human umbilical vein endothelial cells .
26751204	0	PEDF	47,51	Pigment_Epithelium-Derived_Factor	12,45	PEDF	Pigment Epithelium-Derived Factor	57104	57104	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Correction : Pigment_Epithelium-Derived_Factor -LRB- PEDF -RRB- Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells .
12957143	0	PEDF	49,53	VEGF	95,99	PEDF	VEGF	57104	7422	Gene	Gene	pigment_epithelium-derived_factor|appos|START_ENTITY pigment_epithelium-derived_factor|appos|END_ENTITY	Expression of pigment_epithelium-derived_factor -LRB- PEDF -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in sickle cell retina and choroid .
15985268	0	PEDF	35,39	VEGF	113,117	PEDF	VEGF	57104	7422	Gene	Gene	Pigment_epithelium-derived_factor|appos|START_ENTITY Pigment_epithelium-derived_factor|dep|apoptosis apoptosis|nmod|expression expression|appos|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16624340	0	PEDF	35,39	VEGF	109,113	PEDF	VEGF	5176	7422	Gene	Gene	factor|appos|START_ENTITY inhibits|nsubj|factor inhibits|dobj|expression expression|compound|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Pigment-epithelium-derived factor -LRB- PEDF -RRB- inhibits angiotensin-II-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MOLT-3 T cells through anti-oxidative properties .
16735992	0	PEDF	121,125	VEGF	77,81	PEDF	VEGF	20317(Tax:10090)	22339(Tax:10090)	Gene	Gene	migration|appos|START_ENTITY migration|appos|END_ENTITY	Angiostatin decreases cell migration and vascular_endothelium_growth_factor -LRB- VEGF -RRB- to pigment_epithelium_derived_factor -LRB- PEDF -RRB- RNA ratio in vitro and in a murine ocular_melanoma model .
19696171	0	PEDF	85,89	VEGF	34,38	PEDF	VEGF	100337325	281572(Tax:9913)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro .
20049507	0	PEDF	108,112	VEGF	63,67	PEDF	VEGF	5176	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Intra-ocular expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and pigment_epithelial-derived_factor -LRB- PEDF -RRB- in a case of Eales ' _ disease by immunohistochemical analysis : a case report .
22057317	0	PEDF	0,4	VEGF	27,31	PEDF	VEGF	287526(Tax:10116)	83785(Tax:10116)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	PEDF effectively decreases VEGF to PEDF messenger RNA ratio of the inner edge of rat hepatocellular carcinoma induced by diethyl_nitrosamine - an `` in vivo '' study .
22057317	0	PEDF	35,39	VEGF	27,31	PEDF	VEGF	287526(Tax:10116)	83785(Tax:10116)	Gene	Gene	decreases|xcomp|START_ENTITY decreases|dobj|END_ENTITY	PEDF effectively decreases VEGF to PEDF messenger RNA ratio of the inner edge of rat hepatocellular carcinoma induced by diethyl_nitrosamine - an `` in vivo '' study .
26308290	0	PEDF	34,38	VEGF	42,46	PEDF	VEGF	20317(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Inversely Inversely|compound|END_ENTITY	GnRH Agonist Triggering Modulates PEDF to VEGF Ratio Inversely to hCG in Granulosa Cells .
10531367	0	PEDF	46,50	pigment_epithelium-derived_factor	11,44	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of pigment_epithelium-derived_factor -LRB- PEDF -RRB- to retinoblastoma cells and cerebellar granule neurons .
18677713	0	PEDF	51,55	pigment_epithelium-derived_factor	16,49	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are positively associated with visceral adiposity in Japanese patients with type 2 diabetes .
19073347	0	PEDF	51,55	pigment_epithelium-derived_factor	16,49	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are an independent determinant of insulin resistance in patients with essential hypertension .
19275665	0	PEDF	66,70	pigment_epithelium-derived_factor	31,64	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Atheroprotective properties of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in cardiometabolic_disorders .
19685553	0	PEDF	54,58	pigment_epithelium-derived_factor	19,52	PEDF	pigment epithelium-derived factor	287526(Tax:10116)	57104	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Protective role of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in early phase of experimental diabetic_retinopathy .
20423314	0	PEDF	62,66	pigment_epithelium-derived_factor	27,60	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Pathophysiological role of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in hepatic_disorders .
22288782	0	PEDF	51,55	pigment_epithelium-derived_factor	16,49	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are positively associated with acanthosis nigricans in obese adolescents .
22547263	0	PEDF	88,92	pigment_epithelium-derived_factor	53,86	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Insulin resistance is associated with elevated serum pigment_epithelium-derived_factor -LRB- PEDF -RRB- levels in morbidly obese patients .
22884488	0	PEDF	51,55	pigment_epithelium-derived_factor	16,49	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are independently associated with procollagen III N-terminal peptide levels in patients with nonalcoholic_fatty_liver_disease .
23075882	0	PEDF	58,62	pigment_epithelium-derived_factor	23,56	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Hormonal regulation of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in granulosa cells .
23229538	0	PEDF	43,47	pigment_epithelium-derived_factor	8,41	PEDF	pigment epithelium-derived factor	287526(Tax:10116)	287526(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in arsenic-induced cell apoptosis of liver and brain in a rat model .
23884140	0	PEDF	60,64	pigment_epithelium-derived_factor	25,58	PEDF	pigment epithelium-derived factor	20317(Tax:10090)	20317(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Protective role of small pigment_epithelium-derived_factor -LRB- PEDF -RRB- peptide in diabetic_renal_injury .
23887690	0	PEDF	82,86	pigment_epithelium-derived_factor	47,80	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Determination of mesenchymal stem cell fate by pigment_epithelium-derived_factor -LRB- PEDF -RRB- results in increased adiposity and reduced bone mineral content .
24769282	0	PEDF	58,62	pigment_epithelium-derived_factor	23,56	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hormonal regulation of pigment_epithelium-derived_factor -LRB- PEDF -RRB- expression in the endometrium .
25705004	0	PEDF	51,55	pigment_epithelium-derived_factor	16,49	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are inversely associated with circulating levels of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- in humans .
8976566	0	PEDF	80,84	pigment_epithelium-derived_factor	18,51	PEDF	pigment epithelium-derived factor	57104	57104	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|dep|characterization	Recombinant human pigment_epithelium-derived_factor -LRB- PEDF -RRB- : characterization of PEDF overexpressed and secreted by eukaryotic cells .
20141354	0	PEDF	70,74	pigment_epithelium_derived_factor	35,68	PEDF	pigment epithelium derived factor	57104	57104	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Protein_kinase_C_beta -LRB- PRKCB1 -RRB- and pigment_epithelium_derived_factor -LRB- PEDF -RRB- gene polymorphisms and diabetic_retinopathy in a south Indian cohort .
24078214	0	PEDF	46,50	pigment_epithelium_derived_factor	11,44	PEDF	pigment epithelium derived factor	57104	57104	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of pigment_epithelium_derived_factor -LRB- PEDF -RRB- on malignant_peripheral_nerve_sheath_tumours -LRB- MPNSTs -RRB- .
15985268	0	PEDF	35,39	vascular_endothelial_growth_factor	77,111	PEDF	vascular endothelial growth factor	57104	7422	Gene	Gene	Pigment_epithelium-derived_factor|appos|START_ENTITY Pigment_epithelium-derived_factor|dep|apoptosis apoptosis|nmod|expression expression|amod|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16624340	0	PEDF	35,39	vascular_endothelial_growth_factor	73,107	PEDF	vascular endothelial growth factor	5176	7422	Gene	Gene	factor|appos|START_ENTITY inhibits|nsubj|factor inhibits|dobj|expression expression|compound|END_ENTITY	Pigment-epithelium-derived factor -LRB- PEDF -RRB- inhibits angiotensin-II-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MOLT-3 T cells through anti-oxidative properties .
25948043	0	PEDF	46,50	vascular_endothelial_growth_factor	57,91	PEDF	vascular endothelial growth factor	57104	7422	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Recombinant pigment_epithelium-derived_factor PEDF binds vascular_endothelial_growth_factor receptors 1 and 2 .
23818523	0	PEDF-R	88,94	PEDF	73,77	PEDF-R	PEDF	57104	57104	Gene	Gene	Receptor|appos|START_ENTITY Receptor|compound|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- prevents retinal cell death via PEDF Receptor -LRB- PEDF-R -RRB- : identification of a functional ligand binding site .
12620933	0	PEG10	81,86	HERV-W	51,57	PEG10	HERV-W	23089	30816	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Temporal regulation of the expression of syncytin -LRB- HERV-W -RRB- , maternally imprinted PEG10 , and SGCE in human placenta .
20460050	0	PEG10	37,42	MiR-122	1,8	PEG10	MiR-122	23089	406906	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- MiR-122 regulates the expression of PEG10 in hepatoma cell lines -RSB- .
17621626	0	PEG10	52,57	paternally_expressed_gene_10	22,50	PEG10	paternally expressed gene 10	23089	23089	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the paternally_expressed_gene_10 -LRB- PEG10 -RRB- from the imprinted locus on chromosome 7q21 in high-risk B-cell_chronic_lymphocytic_leukemia .
9545322	0	PEL1	4,8	PGS1	23,27	PEL1	PGS1	850352(Tax:4932)	850352(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The PEL1 gene -LRB- renamed PGS1 -RRB- encodes the phosphatidylglycero-phosphate synthase of Saccharomyces_cerevisiae .
23836152	0	PELP1	113,118	ERK	89,92	PELP1	ERK	27043	5594	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Vitamin_C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1 .
22403175	0	PELP1	17,22	androgen_receptor	58,75	PELP1	androgen receptor	27043	367	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Central role for PELP1 in nonandrogenic activation of the androgen_receptor in prostate_cancer .
11420179	0	PEMT	116,120	phosphatidylethanolamine_N-methyltransferase	70,114	PEMT	phosphatidylethanolamine N-methyltransferase	10400	10400	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure , expression profile and alternative processing of the human phosphatidylethanolamine_N-methyltransferase -LRB- PEMT -RRB- gene .
24963152	0	PEMT	112,116	phosphatidylethanolamine_N-methyltransferase	66,110	PEMT	phosphatidylethanolamine N-methyltransferase	18618(Tax:10090)	18618(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Maternal_choline_supplementation programs greater activity of the phosphatidylethanolamine_N-methyltransferase -LRB- PEMT -RRB- pathway in adult Ts65Dn trisomic mice .
16449647	0	PEN-2	30,35	CREB	88,92	PEN-2	CREB	55851	1385	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of PEN-2 , a key component of the gamma-secretase complex , by CREB .
23685131	0	PEN-2	36,41	Ferritin_light_chain	0,20	PEN-2	Ferritin light chain	55851	2512	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ferritin_light_chain interacts with PEN-2 and affects y-secretase activity .
7943650	0	PENK	46,50	preproenkephalin_A	26,44	PENK	preproenkephalin A	5179	5179	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allele frequencies of the preproenkephalin_A -LRB- PENK -RRB- gene CA repeat in Asians , African-Americans , and Caucasians : lack of evidence for different allele frequencies in alcoholics .
11985352	0	PENK	29,33	proenkephalin	14,27	PENK	proenkephalin	18619(Tax:10090)	18619(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of proenkephalin -LRB- PENK -RRB- mRNA in inflammatory leukocytes during experimental peritonitis in Swiss mice .
19425506	0	PEO1	62,66	ANT1	44,48	PEO1	ANT1	56652	291	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	-LSB- Association of the T -LRB- -365 -RRB- C POLG1 , G -LRB- -25 -RRB- A ANT1 and G -LRB- -605 -RRB- T PEO1 gene polymorphisms with diabetic_polyneuropathy in patients with type_1_diabetes_mellitus -RSB- .
24014582	0	PEO1	77,81	C10orf2	68,75	PEO1	C10orf2	56652	56652	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Progressive external ophthalmoplegia -LRB- PEO -RRB- due to a mutation in the C10orf2 -LRB- PEO1 -RRB- gene mimicking a myasthenic_crisis .
14752163	0	PEP	43,46	PEST_domain-enriched_tyrosine_phosphatase	0,41	PEP	PEST domain-enriched tyrosine phosphatase	19260(Tax:10090)	19260(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	PEST_domain-enriched_tyrosine_phosphatase -LRB- PEP -RRB- regulation of effector/memory T cells .
8890164	0	PEP	91,94	p50csk	50,56	PEP	p50csk	5047	1445	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Association of inhibitory tyrosine protein kinase p50csk with protein_tyrosine_phosphatase PEP in T cells and other hemopoietic cells .
3760122	0	PEP	77,80	progestagen-associated_endometrial_protein	33,75	PEP	progestagen-associated endometrial protein	5047	5047	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Luteal phase concentrations of a progestagen-associated_endometrial_protein -LRB- PEP -RRB- in the serum of cycling women with adequate or inadequate endometrium .
10708824	0	PEP	65,68	prolyl_endopeptidase	43,63	PEP	prolyl endopeptidase	5550	5550	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of pregnancy and delivery on serum prolyl_endopeptidase -LRB- PEP -RRB- activity : alterations in serum PEP are related to increased anxiety in the early puerperium and to postpartum depression .
23204517	0	PEP-19	34,40	calmodulin	4,14	PEP-19	calmodulin	5121	808	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The calmodulin regulator protein , PEP-19 , sensitizes ATP-induced Ca2 + release .
7295293	0	PEP-4	33,38	prolidase	22,31	PEP-4	prolidase	18624(Tax:10090)	18624(Tax:10090)	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic variation for prolidase -LRB- PEP-4 -RRB- in the mouse maps near the gene for glucosephosphate_isomerase -LRB- GPI-1 -RRB- on chromosome 7 .
12005059	0	PEP4	148,152	proteinase_A	129,141	PEP4	proteinase A	855949(Tax:4932)	855949(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Construction of protease-deficient Candida boidinii strains useful for recombinant protein production : cloning and disruption of proteinase_A gene -LRB- PEP4 -RRB- and proteinase_B gene -LRB- PRBI -RRB- .
18966765	0	PEPC	58,62	phosphoenolpyruvate-carboxylase	25,56	PEPC	phosphoenolpyruvate-carboxylase	5105	5105	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the enzyme phosphoenolpyruvate-carboxylase -LRB- PEPC -RRB- by different pollutants .
16936335	0	PEPC	72,76	phosphoenolpyruvate_carboxylase	39,70	PEPC	phosphoenolpyruvate carboxylase	5105	5105	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Light regulation of the photosynthetic phosphoenolpyruvate_carboxylase -LRB- PEPC -RRB- in Hydrilla verticillata .
17097062	0	PEPCK	39,44	AMP-activated_protein_kinase	0,28	PEPCK	AMP-activated protein kinase	5106	5563	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	AMP-activated_protein_kinase regulates PEPCK gene expression by direct phosphorylation of a novel zinc finger transcription factor .
12453892	0	PEPCK	92,97	Activating_transcription_factor-2	0,33	PEPCK	Activating transcription factor-2	5106	1386	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	Activating_transcription_factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic_acid .
17094771	0	PEPCK	53,58	C/EBPalpha	130,140	PEPCK	C/EBPalpha	5106	1050	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EBPalpha .
16375695	0	PEPCK	22,27	Insulin	0,7	PEPCK	Insulin	5106	3630	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Insulin regulation of PEPCK gene expression : a model for rapid and reversible modulation .
25999794	0	PEPCK	48,53	Phosphoenolpyruvate_Carboxykinase	13,46	PEPCK	Phosphoenolpyruvate Carboxykinase	378727(Tax:7955)	378727(Tax:7955)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of Phosphoenolpyruvate_Carboxykinase -LRB- PEPCK -RRB- during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes .
22615911	0	PEPCK	65,70	aryl_hydrocarbon_receptor	90,115	PEPCK	aryl hydrocarbon receptor	18534(Tax:10090)	11622(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	PCB_126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl_hydrocarbon_receptor .
1377912	0	PEPCK	49,54	phosphoenolpyruvate_carboxykinase	14,47	PEPCK	phosphoenolpyruvate carboxykinase	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- chimeras in renal epithelial cells .
14652357	0	PEPCK	74,79	phosphoenolpyruvate_carboxykinase	39,72	PEPCK	phosphoenolpyruvate carboxykinase	18534(Tax:10090)	18534(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	RNA_polymerase_II association with the phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- promoter is reduced in vitamin_A-deficient mice .
7982956	0	PEPCK	112,117	phosphoenolpyruvate_carboxykinase	77,110	PEPCK	phosphoenolpyruvate carboxykinase	5106	5106	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Potential convergence of insulin and cAMP signal transduction systems at the phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene promoter through CCAAT/enhancer binding protein -LRB- C/EBP -RRB- .
8114762	0	PEPCK	182,187	phosphoenolpyruvate_carboxykinase	147,180	PEPCK	phosphoenolpyruvate carboxykinase	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Involvement of 3 ' ,5 ' - cyclic_adenosine_monophosphate regulatory element binding protein -LRB- CREB -RRB- in both basal and hormone-mediated expression of the phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene .
8475501	0	PEPCK	56,61	phosphoenolpyruvate_carboxykinase	21,54	PEPCK	phosphoenolpyruvate carboxykinase	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Reduction of hepatic phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- is due to decreased mRNA levels .
20179141	0	PEPR2	0,5	Pep1	35,39	PEPR2	Pep1	838353(Tax:3702)	836613(Tax:3702)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	PEPR2 is a second receptor for the Pep1 and Pep2 peptides and contributes to defense responses in Arabidopsis .
21980510	0	PEPT-1	102,108	glutathione_peroxidase	2,24	PEPT-1	glutathione peroxidase	180919(Tax:6239)	172983(Tax:6239)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	A glutathione_peroxidase , intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. _ elegans .
24380877	0	PEPT1	57,62	Nrf2	0,4	PEPT1	Nrf2	6564	4780	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nrf2 regulates the expression of the peptide transporter PEPT1 in the human colon_carcinoma cell line Caco-2 .
9190878	0	PEPT1	107,112	PEPT1	130,135	PEPT1	PEPT1	117261(Tax:10116)	117261(Tax:10116)	Gene	Gene	START_ENTITY|dep|localization localization|nmod|END_ENTITY	Characterization of stably transfected kidney epithelial cell line expressing rat H + / peptide cotransporter PEPT1 : localization of PEPT1 and transport of beta-lactam antibiotics .
9190878	0	PEPT1	130,135	PEPT1	107,112	PEPT1	PEPT1	117261(Tax:10116)	117261(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|dep|localization	Characterization of stably transfected kidney epithelial cell line expressing rat H + / peptide cotransporter PEPT1 : localization of PEPT1 and transport of beta-lactam antibiotics .
15905415	0	PEPT1	126,131	Sp1	66,69	PEPT1	Sp1	6564	6667	Gene	Gene	regulator|nmod|START_ENTITY functions|nmod|regulator functions|amod|END_ENTITY	Characterization of the human peptide transporter PEPT1 promoter : Sp1 functions as a basal transcriptional regulator of human PEPT1 .
16253763	0	PEPT1	43,48	peptide_transporter_1	20,41	PEPT1	peptide transporter 1	6564	6564	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human peptide_transporter_1 -LRB- PEPT1 -RRB- in gastric_cancer cells by anticancer drugs .
16738539	0	PEPT2	70,75	PDZK1	23,28	PEPT2	PDZK1	6565	5174	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity .
17854384	0	PEPT2	23,28	Peptide_transporter_2	0,21	PEPT2	Peptide transporter 2	57738(Tax:10090)	57738(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Peptide_transporter_2 -LRB- PEPT2 -RRB- expression in brain protects against 5-aminolevulinic_acid neurotoxicity .
19088452	0	PEPT2	24,29	SGK1	64,68	PEPT2	SGK1	380090(Tax:8355)	399130(Tax:8355)	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	The peptide transporter PEPT2 is targeted by the protein kinase SGK1 and the scaffold protein NHERF2 .
3569139	0	PEPck	87,92	phosphoenolpyruvate_carboxykinase	52,85	PEPck	phosphoenolpyruvate carboxykinase	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Nuclear 3,5,3 ' - triiodothyronine receptor occupancy , phosphoenolpyruvate_carboxykinase -LRB- PEPck -RRB- messenger ribonucleic acid levels and PEPck enzyme activity in rat liver .
15809976	0	PER1	33,37	period_1	23,31	PER1	period 1	5187	5187	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of period_1 -LRB- PER1 -RRB- in endometrial_carcinoma .
22905719	0	PER2	10,14	AKT	25,28	PER2	AKT	8864	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Mammalian PER2 regulates AKT activation and DNA damage response .
18430226	0	PER2	40,44	BMAL1	58,63	PER2	BMAL1	8864	406	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK .
22274616	0	PER2	14,18	PML	0,3	PER2	PML	8864	5371	Gene	Gene	localization|nummod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	PML regulates PER2 nuclear localization and circadian function .
23816566	0	PER2	62,66	Period_2	52,60	PER2	Period 2	8864	8864	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Egr1 regulates lithium-induced transcription of the Period_2 -LRB- PER2 -RRB- gene .
23926469	0	PERF15	49,55	Lipid_Binding_Protein	14,35	PERF15	Lipid Binding Protein	646480	646480	Gene	Gene	Gene|dep|START_ENTITY Gene|compound|END_ENTITY	A Novel Human Lipid_Binding_Protein Coding Gene : PERF15 , Sequence and Cloning .
20980603	0	PERIOD	22,28	dCLOCK	46,52	PERIOD	dCLOCK	31251(Tax:7227)	38872(Tax:7227)	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	Two distinct modes of PERIOD recruitment onto dCLOCK reveal a novel role for TIMELESS in circadian transcription .
17274955	0	PERIOD2	83,90	E4BP4	34,39	PERIOD2	E4BP4	8864	4783	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2 .
20538047	0	PERK	39,43	PKR-like_endoplasmic_reticulum_kinase	0,37	PERK	PKR-like endoplasmic reticulum kinase	9451	9451	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	PKR-like_endoplasmic_reticulum_kinase -LRB- PERK -RRB- activation following brain_ischemia is independent of unfolded nascent proteins .
23000413	0	PERK	114,118	eIF2a	120,125	PERK	eIF2a	9451	1965	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK , eIF2a phosphorylation , ATF4-dependent cascade .
24889041	0	PERK	0,4	eIF2a	14,19	PERK	eIF2a	13666(Tax:10090)	13665(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	PERK mediates eIF2a phosphorylation responsible for BACE1 elevation , CREB_dysfunction and neurodegeneration in a mouse model of Alzheimer 's _ disease .
12605680	0	PERK	55,59	eIF2alpha	97,106	PERK	eIF2alpha	9451	32617(Tax:7227)	Gene	Gene	eukaryotic_initiation_factor_2alpha|compound|START_ENTITY eukaryotic_initiation_factor_2alpha|appos|END_ENTITY	Functional characterization of Drosophila_melanogaster PERK eukaryotic_initiation_factor_2alpha -LRB- eIF2alpha -RRB- kinase .
16000157	0	PERK	0,4	eIF2alpha	57,66	PERK	eIF2alpha	13666(Tax:10090)	229317(Tax:10090)	Gene	Gene	responsible|nsubj|START_ENTITY responsible|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain_ischemia .
16124869	0	PERK	0,4	eIF2alpha	6,15	PERK	eIF2alpha	9451	83939	Gene	Gene	START_ENTITY|appos|kinase kinase|amod|END_ENTITY	PERK -LRB- eIF2alpha kinase -RRB- is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis .
16176978	0	PERK	0,4	eIF2alpha	28,37	PERK	eIF2alpha	9451	83939	Gene	Gene	contribute|nsubj|START_ENTITY contribute|nmod|phosphorylation phosphorylation|amod|END_ENTITY	PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway .
17785458	0	PERK	22,26	eIF2alpha	4,13	PERK	eIF2alpha	9451	83939	Gene	Gene	activate|nsubj|START_ENTITY kinases|ccomp|activate kinases|nsubj|END_ENTITY	The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53 .
20072654	0	PERK	54,58	eIF2alpha	77,86	PERK	eIF2alpha	9451	83939	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Regulation of G -LRB- 1 -RRB- arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation .
26449458	0	PERK	66,70	musclin	20,27	PERK	musclin	9451	344901	Gene	Gene	activation|nmod|START_ENTITY increases|nmod|activation increases|dobj|expression expression|amod|END_ENTITY	Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes .
16272432	0	PEROXIN22	99,108	PEROXIN4	62,70	PEROXIN22	PEROXIN4	821741(Tax:3702)	832645(Tax:3702)	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22 .
16272432	0	PEROXIN4	62,70	PEROXIN22	99,108	PEROXIN4	PEROXIN22	832645(Tax:3702)	821741(Tax:3702)	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22 .
10733530	0	PERP	0,4	p53	40,43	PERP	p53	64065	7157	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	PERP , an apoptosis-associated target of p53 , is a novel member of the PMP-22 / gas3 family .
19158346	0	PERP	0,4	p53	8,11	PERP	p53	64065	7157	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	PERP , a p53 proapoptotic target , mediates apoptotic cell death in renal_ischemia .
20011973	0	PES1	19,23	B23	0,3	PES1	B23	23481	4869	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	B23 interacts with PES1 and is involved in nucleolar localization of PES1 .
22820289	0	PES1	0,4	ERa	57,60	PES1	ERa	23481	2099	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	PES1 promotes breast_cancer by differentially regulating ERa and ERb .
24376209	0	PES1	0,4	ERa	48,51	PES1	ERa	23481	26284	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	PES1 differentially regulates the expression of ERa and ERb in ovarian_cancer .
22860098	0	PES1	30,34	c-Jun	49,54	PES1	c-Jun	23481	3725	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of PES1 expression by c-Jun in colon_cancer .
9135065	0	PEST	52,56	Grb2	167,171	PEST	Grb2	19248(Tax:10090)	14784(Tax:10090)	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Coupling of the murine protein tyrosine phosphatase PEST to the epidermal_growth_factor _ -LRB- EGF -RRB- _ receptor through a Src homology 3 -LRB- SH3 -RRB- domain-mediated association with Grb2 .
14752163	0	PEST_domain-enriched_tyrosine_phosphatase	0,41	PEP	43,46	PEST domain-enriched tyrosine phosphatase	PEP	19260(Tax:10090)	19260(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	PEST_domain-enriched_tyrosine_phosphatase -LRB- PEP -RRB- regulation of effector/memory T cells .
9294006	0	PETA-3	61,67	SFA-1	55,60	PETA-3	SFA-1	12476(Tax:10090)	12476(Tax:10090)	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and expression of mouse homologue of SFA-1 / PETA-3 -LRB- CD151 -RRB- , a member of the transmembrane 4 superfamily .
25697797	0	PETAL_LOSS	0,10	AKIN10	129,135	PETAL LOSS	AKIN10	831757(Tax:3702)	821259(Tax:3702)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	PETAL_LOSS , a trihelix transcription factor that represses growth in Arabidopsis_thaliana , binds the energy-sensing SnRK1 kinase AKIN10 .
24141188	0	PETF	30,34	ferredoxin	18,28	PETF	ferredoxin	5718285(Tax:3055)	5716653(Tax:3055)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of ferredoxin , PETF , enhances tolerance to heat_stress in Chlamydomonas_reinhardtii .
10562279	0	PEX12	0,5	PEX5	21,25	PEX12	PEX5	5193	5830	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import .
10026185	1	PEX14	108,113	PEX5	98,102	PEX14	PEX5	5195	5830	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for interaction of PEX5 with PEX14 .
11438541	0	PEX14	160,165	PEX5	77,81	PEX14	PEX5	5195	5830	Gene	Gene	sites|nmod|START_ENTITY sites|nsubj|repeats repeats|nmod|END_ENTITY	The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14 .
24879895	0	PEX14	0,5	PEX5	29,33	PEX14	PEX5	836402(Tax:3702)	835728(Tax:3702)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	PEX14 binding to Arabidopsis PEX5 has differential effects on PTS1 and PTS2 cargo occupancy of the receptor .
15007061	0	PEX19	20,25	PEX3	0,4	PEX19	PEX3	5824	8504	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins .
15007061	0	PEX3	0,4	PEX19	20,25	PEX3	PEX19	8504	5824	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins .
10562279	0	PEX5	21,25	PEX12	0,5	PEX5	PEX12	5830	5193	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import .
10026185	1	PEX5	98,102	PEX14	108,113	PEX5	PEX14	5830	5195	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for interaction of PEX5 with PEX14 .
11438541	0	PEX5	77,81	PEX14	160,165	PEX5	PEX14	5830	5195	Gene	Gene	repeats|nmod|START_ENTITY sites|nsubj|repeats sites|nmod|END_ENTITY	The di-aromatic pentapeptide repeats of the human peroxisome import receptor PEX5 are separate high affinity binding sites for the peroxisomal membrane protein PEX14 .
24879895	0	PEX5	29,33	PEX14	0,5	PEX5	PEX14	835728(Tax:3702)	836402(Tax:3702)	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	PEX14 binding to Arabidopsis PEX5 has differential effects on PTS1 and PTS2 cargo occupancy of the receptor .
11101887	0	PEX5	71,75	TPR	50,53	PEX5	TPR	5830	7175	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5 .
10408779	0	PEX6	66,70	peroxisome_assembly_factor-2	72,100	PEX6	peroxisome assembly factor-2	5190	5190	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Genomic structure and identification of 11 novel mutations of the PEX6 -LRB- peroxisome_assembly_factor-2 -RRB- gene in patients with peroxisome_biogenesis_disorders .
9090383	0	PEX7	70,74	PTS2_receptor	101,114	PEX7	PTS2 receptor	5191	5191	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Rhizomelic_chondrodysplasia_punctata is caused by deficiency of human PEX7 , a homologue of the yeast PTS2_receptor .
23474170	0	PEX7	0,4	iNOS	22,26	PEX7	iNOS	18634(Tax:10090)	18126(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	PEX7 and EBP50 target iNOS to the peroxisome in hepatocytes .
25698787	0	PF-1355	0,7	MPO	27,30	PF-1355	MPO	1469230(Tax:186497)	4353	Gene	Gene	START_ENTITY|appos|Inhibitor Inhibitor|compound|END_ENTITY	PF-1355 , a Mechanism-Based MPO Inhibitor , for the Prevention of Immune-Complex Vasculitis and Anti-GBM Glomerulonephritis .
9499937	0	PF4	0,3	MMP-1	33,38	PF4	MMP-1	5196	4312	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	PF4 inhibits thrombin-stimulated MMP-1 and MMP-3 metalloproteinase expression in human vascular endothelial cells .
12732210	0	PF4	40,43	PREP1	0,5	PF4	PREP1	5196	5316	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PREP1 , MEIS1 homolog protein , regulates PF4 gene expression .
1977142	0	PF4	80,83	PstI	49,53	PF4	PstI	5196	6690	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	Polymerase chain reaction -LRB- PCR -RRB- for detection of PstI polymorphism in the human PF4 gene .
23848403	0	PF4	81,84	RUNX1	0,5	PF4	RUNX1	5196	861	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	RUNX1 , but not its familial platelet_disorder mutants , synergistically activates PF4 gene expression in combination with ETS family proteins .
2881257	0	PF4	53,56	platelet_factor_4	34,51	PF4	platelet factor 4	5196	5196	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An Eco R1 polymorphism of a human platelet_factor_4 -LRB- PF4 -RRB- gene .
3570037	0	PF4	51,54	platelet_factor_4	32,49	PF4	platelet factor 4	5196	5196	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Raised plasma concentrations of platelet_factor_4 -LRB- PF4 -RRB- in Crohn 's _ disease .
6743573	0	PF4	33,36	platelet_factor_4	14,31	PF4	platelet factor 4	5196	5196	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of platelet_factor_4 -LRB- PF4 -RRB- on assays of plasma heparin .
11165514	0	PFK-2	0,5	FBPase-2	6,14	PFK-2	FBPase-2	5209	8789	Gene	Gene	START_ENTITY|appos|bisphosphate bisphosphate|nsubj|END_ENTITY	PFK-2 / FBPase-2 : maker and breaker of the essential biofactor fructose-2 ,6 - bisphosphate .
18039179	0	PFK-2	11,16	FBPase-2	17,25	PFK-2	FBPase-2	5209	8789	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for PFK-2 / FBPase-2 , as distinct from fructose_2 ,6 - bisphosphate , in regulation of insulin secretion in pancreatic beta-cells .
24568531	0	PFKFB2	33,39	MACC1	0,5	PFKFB2	MACC1	5208	346389	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|compound|END_ENTITY	MACC1 expression correlates with PFKFB2 and survival_in_hepatocellular_carcinoma .
12007784	0	PFKFB3	16,22	Insulin	0,7	PFKFB3	Insulin	5209	3630	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Insulin induces PFKFB3 gene expression in HT29 human colon_adenocarcinoma cells .
22811469	0	PFKFB4	31,37	FGF-2	17,22	PFKFB4	FGF-2	270198(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway .
22760208	0	PFT1	29,33	COP1	50,54	PFT1	COP1	839141(Tax:3702)	817857(Tax:3702)	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	The mediator complex subunit PFT1 interferes with COP1 and HY5 in the regulation of Arabidopsis light signaling .
19524571	0	PFTK1	61,66	Cyclin_Y	0,8	PFTK1	Cyclin Y	5218	219771	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cyclin_Y , a novel membrane-associated cyclin , interacts with PFTK1 .
24824184	0	PFTK1	0,5	cyclin_Y	21,29	PFTK1	cyclin Y	5218	219771	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PFTK1 interacts with cyclin_Y to activate non-canonical Wnt signaling in hepatocellular_carcinoma .
2186666	0	PG-M	45,49	proteoglycan	31,43	PG-M	proteoglycan	395565(Tax:9031)	395565(Tax:9031)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of mesenchyme proteoglycan -LRB- PG-M -RRB- during wing bud outgrowth .
10545043	0	PGAM-M	117,123	muscle-specific_phosphoglycerate_mutase	76,115	PGAM-M	muscle-specific phosphoglycerate mutase	5224	5224	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific_phosphoglycerate_mutase -LRB- PGAM-M -RRB- gene .
2612209	0	PGC	34,37	pepsinogen_C	20,32	PGC	pepsinogen C	5225	5225	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Assignment of human pepsinogen_C -LRB- PGC -RRB- gene to chromosome 6 .
11557984	0	PGC-1	63,68	CREB	0,4	PGC-1	CREB	19017(Tax:10090)	12912(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 .
12107181	0	PGC-1	16,21	CREB	196,200	PGC-1	CREB	10891	1385	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|HNF4_alpha HNF4_alpha|appos|END_ENTITY	The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4_alpha and cAMP-response_element-binding_protein -LRB- CREB -RRB- .
23208510	0	PGC-1	4,9	ERR	10,13	PGC-1	ERR	10891	6541	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	The PGC-1 / ERR signaling axis in cancer .
12107181	0	PGC-1	16,21	HNF4_alpha	142,152	PGC-1	HNF4 alpha	10891	3172	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4_alpha and cAMP-response_element-binding_protein -LRB- CREB -RRB- .
12866036	0	PGC-1	107,112	PPARgamma	64,73	PGC-1	PPARgamma	10891	5468	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|peroxisome-proliferator_activated_receptor-gamma peroxisome-proliferator_activated_receptor-gamma|appos|END_ENTITY	Expression of peroxisome-proliferator_activated_receptor-gamma -LRB- PPARgamma -RRB- and the PPARgamma co-activator , PGC-1 , in human breast_cancer correlates with clinical outcomes .
17089023	0	PGC-1	9,14	PPARgamma	15,24	PGC-1	PPARgamma	10891	5468	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Does the PGC-1 / PPARgamma pathway play a role in Com-1 / p8 mediated cell growth inhibition in prostate_cancer ?
26797282	0	PGC-1	63,68	TFAM	69,73	PGC-1	TFAM	10891	7019	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1 / TFAM pathway in human umbilical vein endothelial cells -LRB- HUVECs -RRB- .
12522104	0	PGC-1	32,37	estrogen-related_receptor_alpha	107,138	PGC-1	estrogen-related receptor alpha	10891	2101	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- .
12866036	0	PGC-1	107,112	peroxisome-proliferator_activated_receptor-gamma	14,62	PGC-1	peroxisome-proliferator activated receptor-gamma	10891	5468	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Expression of peroxisome-proliferator_activated_receptor-gamma -LRB- PPARgamma -RRB- and the PPARgamma co-activator , PGC-1 , in human breast_cancer correlates with clinical outcomes .
19940161	0	PGC-1_alpha	0,11	angiotensin_II	72,86	PGC-1 alpha	angiotensin II	10891	183	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	PGC-1_alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin_II drive catalase down-regulation and vascular hypertrophy .
21284983	0	PGC-1a	91,97	ATF6a	98,103	PGC-1a	ATF6a	19017(Tax:10090)	226641(Tax:10090)	Gene	Gene	START_ENTITY|amod|complex complex|nmod:npmod|END_ENTITY	The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1a / ATF6a complex .
23998949	0	PGC-1a	140,146	EP4	10,13	PGC-1a	EP4	10891	5734	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling : the role of PGC-1a and Sp1 .
26804918	0	PGC-1a	4,10	ERRa	11,15	PGC-1a	ERRa	10891	2101	Gene	Gene	START_ENTITY|dep|Metabolism Metabolism|compound|END_ENTITY	The PGC-1a / ERRa Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast_Cancer .
22302939	0	PGC-1a	16,22	FGF21	0,5	PGC-1a	FGF21	19017(Tax:10090)	56636(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	FGF21 regulates PGC-1a and browning of white_adipose_tissues in adaptive thermogenesis .
23943793	0	PGC-1a	26,32	FGF21	9,14	PGC-1a	FGF21	10891	26291	Gene	Gene	expression|amod|START_ENTITY secretion|appos|expression secretion|compound|END_ENTITY	Elevated FGF21 secretion , PGC-1a and ketogenic enzyme expression are hallmarks of iron-sulfur cluster depletion in human skeletal muscle .
24120943	0	PGC-1a	44,50	FNDC5	51,56	PGC-1a	FNDC5	19017(Tax:10090)	384061(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Exercise induces hippocampal BDNF through a PGC-1a / FNDC5 pathway .
21784897	0	PGC-1a	55,61	IHG-1	0,5	PGC-1a	IHG-1	10891	54974	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1a .
25880742	0	PGC-1a	0,6	IRF-1	48,53	PGC-1a	IRF-1	19017(Tax:10090)	16362(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	PGC-1a regulates the expression and activity of IRF-1 .
25880742	0	PGC-1a	0,6	IRF-1	48,53	PGC-1a	IRF-1	19017(Tax:10090)	16362(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	PGC-1a regulates the expression and activity of IRF-1 .
24008097	0	PGC-1a	11,17	Ndrg2	0,5	PGC-1a	Ndrg2	19017(Tax:10090)	29811(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Ndrg2 is a PGC-1a / ERRa target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes .
21376232	0	PGC-1a	29,35	PARIS	0,5	PGC-1a	PARIS	10891	155061	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	PARIS -LRB- ZNF746 -RRB- repression of PGC-1a contributes to neurodegeneration in Parkinson 's _ disease .
23948478	0	PGC-1a	19,25	PPAR	26,30	PGC-1a	PPAR	83516(Tax:10116)	25747(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	Regulatory role of PGC-1a / PPAR signaling in skeletal muscle metabolic recruitment during cold acclimation .
25614670	0	PGC-1a	52,58	PPAR-a	59,65	PGC-1a	PPAR-a	10891	5465	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1a / PPAR-a Signaling .
21286700	0	PGC-1a	92,98	PPARa	50,55	PGC-1a	PPARa	10891	5465	Gene	Gene	regulation|appos|START_ENTITY gamma|dobj|regulation gamma|nsubj|Peroxisome_proliferator_activated_receptor-alpha Peroxisome_proliferator_activated_receptor-alpha|appos|END_ENTITY	Peroxisome_proliferator_activated_receptor-alpha -LRB- PPARa -RRB- and PPAR gamma coactivator-1alpha -LRB- PGC-1a -RRB- regulation of cardiac metabolism in diabetes .
22033933	0	PGC-1a	83,89	PPARa	46,51	PGC-1a	PPARa	10891	5465	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Peroxisome proliferator-activated receptor a -LRB- PPARa -RRB- induces PPARy coactivator 1a -LRB- PGC-1a -RRB- gene expression and contributes to thermogenic activation of brown fat : involvement of PRDM16 .
21933665	0	PGC-1a	23,29	PXR	49,52	PGC-1a	PXR	10891	8856	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Energy sensing factors PGC-1a and SIRT1 modulate PXR expression and function .
24757201	0	PGC-1a	78,84	SIRT-1	71,77	PGC-1a	SIRT-1	19017(Tax:10090)	93759(Tax:10090)	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1 / PGC-1a network in skeletal muscle .
25614670	0	PGC-1a	52,58	SIRT1	35,40	PGC-1a	SIRT1	10891	23411	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1a / PPAR-a Signaling .
26535995	0	PGC-1a	42,48	TWEAK	26,31	PGC-1a	TWEAK	19017(Tax:10090)	21944(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	The inflammatory cytokine TWEAK decreases PGC-1a expression and mitochondrial function in acute kidney_injury .
21376232	0	PGC-1a	29,35	ZNF746	7,13	PGC-1a	ZNF746	10891	155061	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	PARIS -LRB- ZNF746 -RRB- repression of PGC-1a contributes to neurodegeneration in Parkinson 's _ disease .
21338289	0	PGC-1a	0,6	translocated_in_liposarcoma	17,44	PGC-1a	translocated in liposarcoma	10891	2521	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	PGC-1a regulates translocated_in_liposarcoma activity : role in oxidative stress gene expression .
20357764	0	PGC-1alpha	33,43	Adiponectin	0,11	PGC-1alpha	Adiponectin	10891	9370	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca -LRB- 2 + -RRB- and AMPK/SIRT1 .
16203862	0	PGC-1alpha	0,10	Akt	48,51	PGC-1alpha	Akt	10891	207	Gene	Gene	expression|amod|START_ENTITY down-regulated|nsubjpass|expression down-regulated|nmod|END_ENTITY	PGC-1alpha gene expression is down-regulated by Akt - mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle .
18602936	0	PGC-1alpha	12,22	CYP2A5	86,92	PGC-1alpha	CYP2A5	19017(Tax:10090)	13087(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes .
14522988	0	PGC-1alpha	0,10	CYP7A1	21,27	PGC-1alpha	CYP7A1	19017(Tax:10090)	13122(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	PGC-1alpha activates CYP7A1 and bile_acid biosynthesis .
19723495	0	PGC-1alpha	27,37	DNMT3B	55,61	PGC-1alpha	DNMT3B	10891	1789	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density .
15087503	0	PGC-1alpha	90,100	ERRalpha	37,45	PGC-1alpha	ERRalpha	10891	2101	Gene	Gene	functions|appos|START_ENTITY functions|appos|END_ENTITY	The estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- functions in PPARgamma coactivator 1alpha -LRB- PGC-1alpha -RRB- - induced mitochondrial biogenesis .
15184675	0	PGC-1alpha	44,54	ERRalpha	105,113	PGC-1alpha	ERRalpha	10891	2101	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|ligand ligand|appos|END_ENTITY	Regulation of PPARgamma coactivator 1alpha -LRB- PGC-1alpha -RRB- signaling by an estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- ligand .
16314495	0	PGC-1alpha	0,10	ERRalpha	76,84	PGC-1alpha	ERRalpha	10891	2101	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha : a mechanism for transcriptional control of muscle glucose metabolism .
16623704	0	PGC-1alpha	52,62	ERRalpha	18,26	PGC-1alpha	ERRalpha	10891	2101	Gene	Gene	partner|nmod|START_ENTITY Identification|nmod|partner Identification|nmod|END_ENTITY	Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle .
18673300	0	PGC-1alpha	0,10	ERRalpha	55,63	PGC-1alpha	ERRalpha	10891	2101	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|nucleosome nucleosome|compound|END_ENTITY	PGC-1alpha induces dynamic protein interactions on the ERRalpha gene multi-hormone response element nucleosome in kidney cells .
19541642	0	PGC-1alpha	14,24	FGF21	0,5	PGC-1alpha	FGF21	19017(Tax:10090)	56636(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	FGF21 induces PGC-1alpha and regulates carbohydrate and fatty_acid metabolism during the adaptive starvation response .
20018698	0	PGC-1alpha	0,10	FGF21	40,45	PGC-1alpha	FGF21	19017(Tax:10090)	56636(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb -LRB- alpha -RRB- axis .
16314495	0	PGC-1alpha	0,10	PDK4	23,27	PGC-1alpha	PDK4	10891	5166	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha : a mechanism for transcriptional control of muscle glucose metabolism .
16623704	0	PGC-1alpha	52,62	PDK4	85,89	PGC-1alpha	PDK4	10891	5166	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|expression expression|compound|END_ENTITY	Identification of ERRalpha as a specific partner of PGC-1alpha for the activation of PDK4 gene expression in muscle .
21280563	0	PGC-1alpha	76,86	PPAR_gamma_co-activator_1_alpha	43,74	PGC-1alpha	PPAR gamma co-activator 1 alpha	19017(Tax:10090)	19017(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Long-term caloric restriction up-regulates PPAR_gamma_co-activator_1_alpha -LRB- PGC-1alpha -RRB- expression in mice .
16950137	0	PGC-1alpha	49,59	PPARalpha	60,69	PGC-1alpha	PPARalpha	19017(Tax:10090)	19013(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Lipin_1 is an inducible amplifier of the hepatic PGC-1alpha / PPARalpha regulatory pathway .
17275789	0	PGC-1alpha	40,50	PPARdelta	0,9	PGC-1alpha	PPARdelta	10891	5467	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	PPARdelta , but not PPARalpha , activates PGC-1alpha gene transcription in muscle .
16213225	0	PGC-1alpha	42,52	SHP	28,31	PGC-1alpha	SHP	19017(Tax:10090)	23957(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes .
20661474	0	PGC-1alpha	27,37	Sirtuin_3	0,9	PGC-1alpha	Sirtuin 3	10891	23410	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Sirtuin_3 , a new target of PGC-1alpha , plays an important role in the suppression of ROS and mitochondrial biogenesis .
15699338	0	PGC-1alpha	28,38	Sox9	85,89	PGC-1alpha	Sox9	10891	6662	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9 .
19345188	0	PGC-1alpha	65,75	Twist-1	0,7	PGC-1alpha	Twist-1	19017(Tax:10090)	22160(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Twist-1 is a PPARdelta-inducible , negative-feedback regulator of PGC-1alpha in brown fat metabolism .
18288196	0	PGC-1alpha	87,97	VEGF	30,34	PGC-1alpha	VEGF	19017(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha .
18501443	0	PGC-1alpha	33,43	apelin	57,63	PGC-1alpha	apelin	10891	8862	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes .
16631115	0	PGC-1alpha	124,134	mitochondrial_transcription_factor_A	139,175	PGC-1alpha	mitochondrial transcription factor A	10891	7019	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Impaired coactivator activity of the Gly482 variant of peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha -LRB- PGC-1alpha -RRB- on mitochondrial_transcription_factor_A -LRB- Tfam -RRB- promoter .
20713602	0	PGC-1alpha	63,73	p107	44,48	PGC-1alpha	p107	19017(Tax:10090)	19650(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Oxidative status of muscle is determined by p107 regulation of PGC-1alpha .
16765661	0	PGC-1alpha	0,10	parathyroid_hormone	25,44	PGC-1alpha	parathyroid hormone	83516(Tax:10116)	24694(Tax:10116)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	PGC-1alpha is induced by parathyroid_hormone and coactivates Nurr1-mediated promoter activity in osteoblasts .
17261654	0	PGC-1alpha	130,140	peroxisome_proliferator-activated_receptor-alpha	81,129	PGC-1alpha	peroxisome proliferator-activated receptor-alpha	19017(Tax:10090)	19013(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome_proliferator-activated_receptor-alpha / PGC-1alpha gene regulatory pathway .
17479445	0	PGC-1alpha	79,89	peroxisome_proliferator-activated_receptor_gamma_coactivator-1_alpha	4,72	PGC-1alpha	peroxisome proliferator-activated receptor gamma coactivator-1 alpha	10891	10891	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The peroxisome_proliferator-activated_receptor_gamma_coactivator-1_alpha gene -LRB- PGC-1alpha -RRB- is not associated with type_2_diabetes_mellitus or body mass index among Hispanic and non Hispanic Whites from Colorado .
15649578	0	PGC-1alpha	114,124	peroxisome_proliferator-activated_receptor_gamma_coactivator_1alpha	45,112	PGC-1alpha	peroxisome proliferator-activated receptor gamma coactivator 1alpha	10891	10891	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Studies of the Gly482Ser polymorphism of the peroxisome_proliferator-activated_receptor_gamma_coactivator_1alpha -LRB- PGC-1alpha -RRB- gene in Danish subjects with the metabolic_syndrome .
12734177	0	PGC-1alpha	105,115	peroxisome_proliferator-activated_receptor_gamma_coactivators_1alpha_and_1beta	25,103	PGC-1alpha	peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta	10891	10891;133522	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Bioenergetic analysis of peroxisome_proliferator-activated_receptor_gamma_coactivators_1alpha_and_1beta -LRB- PGC-1alpha and PGC-1beta -RRB- in muscle cells .
20889132	0	PGC-1b	42,48	ApoC3	22,27	PGC-1b	ApoC3	170826(Tax:10090)	11814(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of hepatic ApoC3 expression by PGC-1b mediates hypolipidemic effect of nicotinic_acid .
12678921	0	PGC1_beta	45,54	peroxisome-proliferator-activated_receptor-gamma_co-activator_1_beta	56,124	PGC1 beta	peroxisome-proliferator-activated receptor-gamma co-activator 1 beta	291567(Tax:10116)	291567(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Characterization of the human , mouse and rat PGC1_beta -LRB- peroxisome-proliferator-activated_receptor-gamma_co-activator_1_beta -RRB- gene in vitro and in vivo .
26890141	0	PGC1a	32,37	HSF1	118,122	PGC1a	HSF1	19017(Tax:10090)	15499(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	The transcriptional coactivator PGC1a protects against hyperthermic stress via cooperation with the heat_shock factor HSF1 .
21518958	0	PGC1a	44,49	Kinase_suppressor_of_ras_1	0,26	PGC1a	Kinase suppressor of ras 1	19017(Tax:10090)	16706(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Kinase_suppressor_of_ras_1 -LRB- KSR1 -RRB- regulates PGC1a and estrogen-related receptor a to promote oncogenic Ras-dependent anchorage-independent growth .
26218179	0	PGC1a	52,57	Leptin	0,6	PGC1a	Leptin	10891	3952	Gene	Gene	Effect|nmod|START_ENTITY Effect|compound|END_ENTITY	Leptin Effect on Acetylation and Phosphorylation of PGC1a in Muscle Cells Associated With AMPK and Akt Activation in High-Glucose Medium .
25516445	0	PGC1a	18,23	p62	44,47	PGC1a	p62	10891	23636	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of PGC1a and accumulation of p62 in apocrine_carcinoma_of_the_breast .
22705949	0	PGC1alpha	52,61	alpha-synuclein	29,44	PGC1alpha	alpha-synuclein	10891	6622	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function : implications for Parkinson 's _ disease .
20519122	0	PGC1beta	0,8	PPARgamma	18,27	PGC1beta	PPARgamma	170826(Tax:10090)	19016(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone_loss .
18212515	0	PGD2	58,62	CRTH2	0,5	PGD2	CRTH2	5730	11251	Gene	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	CRTH2 is not involved in the anti-enteropooling effect of PGD2 in the small intestine .
22206772	0	PGD2	0,4	eotaxin-3	13,22	PGD2	eotaxin-3	5730	10344	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PGD2 induces eotaxin-3 via PPARy from sebocytes : a possible pathogenesis of eosinophilic_pustular_folliculitis .
7036145	0	PGD2	32,36	prostaglandin_D2	14,30	PGD2	prostaglandin D2	5730	5730	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of prostaglandin_D2 -LRB- PGD2 -RRB- as an anticoagulative agent for haemodialysis in comparison with prostaglandin_E1 -LRB- PGE1 -RRB- .
15531523	0	PGDH	53,57	15-hydroxyprostaglandin_dehydrogenase	14,51	PGDH	15-hydroxyprostaglandin dehydrogenase	3248	873	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of 15-hydroxyprostaglandin_dehydrogenase -LRB- PGDH -RRB- gene activity , messenger ribonucleic acid processing , and protein abundance in the human chorion in late gestation and labor .
317602	0	PGDH	72,76	prostaglandin_dehydrogenase	43,70	PGDH	prostaglandin dehydrogenase	15446(Tax:10090)	15446(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Effect of ionizing radiation on 15-hydroxy prostaglandin_dehydrogenase -LRB- PGDH -RRB- activity in tissues .
6206113	0	PGDH	79,83	prostaglandin_dehydrogenase	50,77	PGDH	prostaglandin dehydrogenase	79242(Tax:10116)	79242(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Effect of exposure to diesel exhaust on pulmonary prostaglandin_dehydrogenase -LRB- PGDH -RRB- activity .
23338946	0	PGF	93,96	G-Protein_coupled_receptor_64	0,29	PGF	G-Protein coupled receptor 64	18654(Tax:10090)	237175(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	G-Protein_coupled_receptor_64 promotes invasiveness and metastasis in Ewing_sarcomas through PGF and MMP1 .
18160678	0	PGF	56,59	placental_growth_factor	31,54	PGF	placental growth factor	5228	5228	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Glial_cell_missing_1 regulates placental_growth_factor -LRB- PGF -RRB- gene transcription in human trophoblast .
10750035	0	PGHS-1	47,53	prostaglandin_synthase_type-1	16,45	PGHS-1	prostaglandin synthase type-1	443551(Tax:9940)	443551(Tax:9940)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of prostaglandin_synthase_type-1 -LRB- PGHS-1 -RRB- mRNA and prostaglandin_synthase_type-2 -LRB- PGHS-2 -RRB- mRNA in ovine myometrium and endometrium throughout gestation .
10750035	0	PGHS-2	95,101	prostaglandin_synthase_type-2	64,93	PGHS-2	prostaglandin synthase type-2	443460(Tax:9940)	443460(Tax:9940)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of prostaglandin_synthase_type-1 -LRB- PGHS-1 -RRB- mRNA and prostaglandin_synthase_type-2 -LRB- PGHS-2 -RRB- mRNA in ovine myometrium and endometrium throughout gestation .
12174867	0	PGK1	51,55	phosphoglycerate_kinase_1	24,49	PGK1	phosphoglycerate kinase 1	5230	5230	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of human phosphoglycerate_kinase_1 -LRB- PGK1 -RRB- induces a multidrug resistance phenotype .
1765379	0	PGK1	96,100	phosphoglycerate_kinase_1	69,94	PGK1	phosphoglycerate kinase 1	5230	5230	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Nucleotide sequence of the 3 ' nuclease-sensitive region of the human phosphoglycerate_kinase_1 -LRB- PGK1 -RRB- gene .
15599558	0	PGK2	85,89	testis-specific_phosphoglycerate_kinase_2	42,83	PGK2	testis-specific phosphoglycerate kinase 2	396673(Tax:9823)	396673(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of the porcine testis-specific_phosphoglycerate_kinase_2 -LRB- PGK2 -RRB- gene and its association with male fertility .
16876970	0	PGM	67,70	phosphoglucomutase	47,65	PGM	phosphoglucomutase	105348078	105348078	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular identification and expression of the phosphoglucomutase -LRB- PGM -RRB- gene from the Pacific_oyster Crassostrea_gigas .
2935481	0	PGM1	70,74	phosphoglucomutase_1	41,61	PGM1	phosphoglucomutase 1	5236	5236	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	A new partially deficient variant in the phosphoglucomutase_1 system , PGM1 * W31 .
6462057	0	PGM1	41,45	phosphoglucomutase_locus_1	13,39	PGM1	phosphoglucomutase locus 1	5236	5236	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Subtyping of phosphoglucomutase_locus_1 -LRB- PGM1 -RRB- polymorphism in some populations of Rwanda : description of variant phenotypes , `` haplotype '' frequencies , and linkage disequilibrium data .
24589341	0	PGM3	42,46	phosphoglucomutase_3	20,40	PGM3	phosphoglucomutase 3	5238	5238	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Autosomal recessive phosphoglucomutase_3 -LRB- PGM3 -RRB- mutations link glycosylation defects to atopy , immune_deficiency , autoimmunity , and neurocognitive_impairment .
26482871	0	PGM3	142,146	phosphoglucomutase_3	120,140	PGM3	phosphoglucomutase 3	5238	5238	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Susceptibility to infections , without concomitant hyper-IgE , reported in 1976 , is caused by hypomorphic mutation in the phosphoglucomutase_3 -LRB- PGM3 -RRB- gene .
17038883	0	PGP	41,44	P-glycoprotein	25,39	PGP	P-glycoprotein	5243	5243	Gene	Gene	relationship|appos|START_ENTITY relationship|nmod|END_ENTITY	The relationship between P-glycoprotein -LRB- PGP -RRB- polymorphisms and response to olanzapine treatment in schizophrenia .
19484671	0	PGP	116,119	P-glycoprotein	100,114	PGP	P-glycoprotein	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The anti-inflammatory effects of inhaled corticosteroids versus anti-leukotrienes on the lymphocyte P-glycoprotein -LRB- PGP -RRB- expression in asthmatic children .
23888777	0	PGP	43,46	Vegfa	50,55	PGP	Vegfa	287115(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- The effect of semax and its C-end peptide PGP on Vegfa gene expression in the rat brain during incomplete global ischemia -RSB- .
26286601	0	PGR	23,26	Progesterone_Receptor	0,21	PGR	Progesterone Receptor	5241	5241	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Progesterone_Receptor -LRB- PGR -RRB- gene polymorphism is associated with susceptibility to preterm_birth .
16033068	0	PGR	50,53	progesterone_receptor	27,48	PGR	progesterone receptor	5241	5241	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the human progesterone_receptor -LRB- PGR -RRB- gene of two human prostate_adenocarcinoma cell lines .
24680695	0	PGRMC1	44,50	Progesterone_receptor_membrane_component_1	0,42	PGRMC1	Progesterone receptor membrane component 1	10857	10857	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Progesterone_receptor_membrane_component_1 -LRB- PGRMC1 -RRB- expression in fetal membranes among women with preterm premature_rupture of the membranes -LRB- PPROM -RRB- .
24424068	0	PGRMC1	181,187	mPRa	96,100	PGRMC1	mPRa	10857	20200(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role END_ENTITY|dep|evidence	Enhancement of cell surface expression and receptor functions of membrane progestin receptor a -LRB- mPRa -RRB- by progesterone_receptor membrane component 1 -LRB- PGRMC1 -RRB- : evidence for a role of PGRMC1 as an adaptor protein for steroid receptors .
21637418	0	PGRMC2	103,109	progesterone_receptor_membrane_component_2	59,101	PGRMC2	progesterone receptor membrane component 2	100048965(Tax:9823)	100048965(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning , mapping and molecular characterization of porcine progesterone_receptor_membrane_component_2 -LRB- PGRMC2 -RRB- gene .
18848708	0	PGRN	13,17	Progranulin	0,11	PGRN	Progranulin	2896	2896	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Progranulin -LRB- PGRN -RRB- expression in ALS : an immunohistochemical study .
20930269	0	PGRN	126,130	progranulin	108,119	PGRN	progranulin	2896	2896	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Intra-familial clinical heterogeneity due to FTLD-U with TDP-43_proteinopathy caused by a novel deletion in progranulin gene -LRB- PGRN -RRB- .
26600492	0	PGRN	23,27	progranulin	10,21	PGRN	progranulin	2896	2896	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of progranulin -LRB- PGRN -RRB- on the proliferation and senescence of cervical cancer cells .
17689997	0	PGRP	41,45	peptidoglycan_recognition_protein	6,39	PGRP	peptidoglycan recognition protein	100862794	100862794	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Three peptidoglycan_recognition_protein -LRB- PGRP -RRB- genes encoding potential amidase from eri-silkworm , Samia_cynthia_ricini .
23416224	0	PGRP	79,83	peptidoglycan_recognition_protein	44,77	PGRP	peptidoglycan recognition protein	105331238	105331238	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The first evidence of positive selection in peptidoglycan_recognition_protein -LRB- PGRP -RRB- genes of Crassostrea_gigas .
25139117	0	PGRP-LC	141,148	TM9SF2	16,22	PGRP-LC	TM9SF2	39063(Tax:7227)	35335(Tax:7227)	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|dep|Localization	The Nonaspanins TM9SF2 and TM9SF4 Regulate the Plasma Membrane Localization and Signalling Activity of the Peptidoglycan_Recognition_Protein PGRP-LC in Drosophila .
8663219	0	PGS-2	66,71	prostaglandin_endoperoxide_synthase-2	27,64	PGS-2	prostaglandin endoperoxide synthase-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	An E-box region within the prostaglandin_endoperoxide_synthase-2 -LRB- PGS-2 -RRB- promoter is required for transcription in rat ovarian granulosa cells .
9545322	0	PGS1	23,27	PEL1	4,8	PGS1	PEL1	850352(Tax:4932)	850352(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The PEL1 gene -LRB- renamed PGS1 -RRB- encodes the phosphatidylglycero-phosphate synthase of Saccharomyces_cerevisiae .
10484490	0	PGT	43,46	prostaglandin_transporter	17,42	PGT	prostaglandin transporter	6578	24059(Tax:10090)	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Cloning of mouse prostaglandin_transporter PGT cDNA : species-specific substrate affinities .
3027667	0	PG_II	25,30	PG_II	60,65	PG II	PG II	1634	1634	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Characterization of bone PG_II cDNA and its relationship to PG_II mRNA from other connective tissues .
3027667	0	PG_II	60,65	PG_II	25,30	PG II	PG II	1634	1634	Gene	Gene	mRNA|compound|START_ENTITY END_ENTITY|nmod|mRNA	Characterization of bone PG_II cDNA and its relationship to PG_II mRNA from other connective tissues .
12932297	0	PH-20	7,12	SPAM1	0,5	PH-20	SPAM1	6677	6677	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	SPAM1 -LRB- PH-20 -RRB- protein and mRNA expression in the epididymides of humans and macaques : utilizing laser microdissection/RT-PCR .
15175239	0	PH-20	7,12	Spam1	0,5	PH-20	Spam1	20690(Tax:10090)	20690(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Spam1 -LRB- PH-20 -RRB- expression in the extratesticular duct and accessory organs of the mouse : a possible role in sperm fluid reabsorption .
9341116	0	PHAS-I	45,51	eIF2B	16,21	PHAS-I	eIF2B	116636(Tax:10116)	117019(Tax:10116)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells .
9443814	0	PHBP	73,77	HABP2	85,90	PHBP	HABP2	3026	3026	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the plasma_hyaluronan-binding_protein -LRB- PHBP -RRB- gene -LRB- HABP2 -RRB- .
9443814	0	PHBP	73,77	plasma_hyaluronan-binding_protein	38,71	PHBP	plasma hyaluronan-binding protein	3026	3026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the plasma_hyaluronan-binding_protein -LRB- PHBP -RRB- gene -LRB- HABP2 -RRB- .
17001316	0	PHC3	0,4	E2F6	57,61	PHC3	E2F6	80012	1876	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	PHC3 , a component of the hPRC-H complex , associates with E2F6 during G0 and is lost in osteosarcoma_tumors .
26211444	0	PHD-2	106,111	SIRT-3	99,105	PHD-2	SIRT-3	308913(Tax:10116)	293615(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Minocycline ameliorates hypoxia-induced blood-brain barrier damage by inhibition of HIF-1a through SIRT-3 / PHD-2 degradation pathway .
21951999	0	PHD1	0,4	ATF4	20,24	PHD1	ATF4	112398	468	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation .
24581673	0	PHD2	29,33	Prolyl_hydroxylase_domain-2	0,27	PHD2	Prolyl hydroxylase domain-2	54583	54583	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Prolyl_hydroxylase_domain-2 -LRB- PHD2 -RRB- inhibition may be a better therapeutic strategy in renal_anemia .
20404338	0	PHD2	97,101	prolyl_hydroxylase_domain-containing_protein_2	49,95	PHD2	prolyl hydroxylase domain-containing protein 2	54583	54583	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of hypoxia-inducible factor-targeting prolyl_hydroxylase_domain-containing_protein_2 -LRB- PHD2 -RRB- enhances matrix synthesis by human chondrocytes .
17933562	0	PHD2	177,181	prolyl_hydroxylase_domain_protein_2	140,175	PHD2	prolyl hydroxylase domain protein 2	54583	54583	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Disturbance in the HIF-1alpha pathway associated with erythrocytosis : further evidences brought by frameshift and nonsense mutations in the prolyl_hydroxylase_domain_protein_2 -LRB- PHD2 -RRB- gene .
21828119	0	PHD2	144,148	prolyl_hydroxylase_domain_protein_2	107,142	PHD2	prolyl hydroxylase domain protein 2	54583	54583	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolated erythrocytosis : study of 67 patients and identification of three novel germ-line mutations in the prolyl_hydroxylase_domain_protein_2 -LRB- PHD2 -RRB- gene .
20599946	0	PHD3	46,50	PRP19	6,11	PHD3	PRP19	112399	27339	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia .
25088999	0	PHD3	19,23	pyruvate_dehydrogenase	39,61	PHD3	pyruvate dehydrogenase	112399	54704	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Prolyl-hydroxylase PHD3 interacts with pyruvate_dehydrogenase -LRB- PDH -RRB- - E1b and regulates the cellular PDH activity .
24048703	0	PHD4	0,4	TGF-a	61,66	PHD4	TGF-a	54681	7039	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|cells cells|nmod|END_ENTITY	PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-a .
21320718	0	PHD_finger_protein_11	55,76	PHF11	83,88	PHD finger protein 11	PHF11	51131	51131	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allele-specific transcription of the asthma-associated PHD_finger_protein_11 gene -LRB- PHF11 -RRB- modulated by octamer-binding_transcription_factor_1 -LRB- Oct-1 -RRB- .
26093023	0	PHENYLALANINE_AMMONIA_LYASE	11,38	PAL	40,43	PHENYLALANINE AMMONIA LYASE	PAL	100829928	100829928	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of PHENYLALANINE_AMMONIA_LYASE -LRB- PAL -RRB- knockdown on cell wall composition , biomass digestibility , and biotic and abiotic stress responses in Brachypodium .
22339660	0	PHEX	60,64	DMP1	73,77	PHEX	DMP1	5251	1758	Gene	Gene	START_ENTITY|appos|ASARM ASARM|appos|END_ENTITY	Regulation of bone-renal mineral and energy metabolism : the PHEX , FGF23 , DMP1 , MEPE ASARM pathway .
21507898	0	PHEX	14,18	Fgf23	64,69	PHEX	Fgf23	18675(Tax:10090)	64654(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor -LRB- FGFR -RRB- signaling .
15664000	0	PHEX	60,64	MEPE	46,50	PHEX	MEPE	18675(Tax:10090)	94111(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Surface plasmon resonance -LRB- SPR -RRB- confirms that MEPE binds to PHEX via the MEPE-ASARM motif : a model for impaired_mineralization in X-linked_rickets -LRB- HYP -RRB- .
22339660	0	PHEX	60,64	MEPE	79,83	PHEX	MEPE	5251	56955	Gene	Gene	START_ENTITY|appos|ASARM ASARM|appos|END_ENTITY	Regulation of bone-renal mineral and energy metabolism : the PHEX , FGF23 , DMP1 , MEPE ASARM pathway .
15940367	0	PHEX	24,28	beta-actin	45,55	PHEX	beta-actin	5251	728378	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype .
18285464	0	PHF1	14,18	Ezh2	0,4	PHF1	Ezh2	5252	2146	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Ezh2 requires PHF1 to efficiently catalyze H3_lysine 27 trimethylation in vivo .
21320718	0	PHF11	83,88	PHD_finger_protein_11	55,76	PHF11	PHD finger protein 11	51131	51131	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allele-specific transcription of the asthma-associated PHD_finger_protein_11 gene -LRB- PHF11 -RRB- modulated by octamer-binding_transcription_factor_1 -LRB- Oct-1 -RRB- .
23979597	0	PHF8	39,43	CDC20	117,122	PHF8	CDC20	320595(Tax:10090)	107995(Tax:10090)	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting_complex containing CDC20 .
18378410	0	PHGDH	84,89	3-phosphoglycerate_dehydrogenase	50,82	PHGDH	3-phosphoglycerate dehydrogenase	26227	26227	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Positive regulation of promoter activity of human 3-phosphoglycerate_dehydrogenase -LRB- PHGDH -RRB- gene is mediated by transcription factors Sp1 and NF-Y .
17516241	0	PHGPx	51,56	Phospholipid_hydroperoxide_glutathione_peroxidase	0,49	PHGPx	Phospholipid hydroperoxide glutathione peroxidase	2879	2879	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Phospholipid_hydroperoxide_glutathione_peroxidase -LRB- PHGPx -RRB- expression is downregulated in poorly differentiated breast_invasive_ductal_carcinoma .
23119750	0	PHI	40,43	phosphohexose_isomerase	15,38	PHI	phosphohexose isomerase	2821	2821	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Study of serum phosphohexose_isomerase -LRB- PHI -RRB- levels in the management of head and neck_malignancies .
9600238	0	PHKA2	124,129	phosphorylase_kinase	103,123	PHKA2	phosphorylase kinase	5256	5256	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Variability of biochemical and clinical phenotype in X-linked_liver_glycogenosis with mutations in the phosphorylase_kinase PHKA2 gene .
22958125	0	PHLDA1	27,33	TDAG51	35,41	PHLDA1	TDAG51	22822	22822	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of PHLDA1 -LRB- TDAG51 -RRB- in basal_cell_carcinoma and trichoepithelioma .
17303335	0	PHLDA2	16,22	Dicer	26,31	PHLDA2	Dicer	7262	23405	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|cells cells|compound|END_ENTITY	Upregulation of PHLDA2 in Dicer knockdown HEK293 cells .
19203586	0	PHLDA3	23,29	Akt	62,65	PHLDA3	Akt	23612	207	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt .
24530606	0	PHLPP	0,5	RAF1	33,37	PHLPP	RAF1	98432(Tax:10090)	110157(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PHLPP is a negative regulator of RAF1 , which reduces colorectal_cancer cell motility and prevents tumor progression in mice .
20576936	0	PHLPP-1	0,7	Akt	29,32	PHLPP-1	Akt	98432(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	PHLPP-1 negatively regulates Akt activity and survival in the heart .
22044669	0	PHLPP1	16,22	Akt2	33,37	PHLPP1	Akt2	23239	208	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The phosphatase PHLPP1 regulates Akt2 , promotes pancreatic_cancer cell death , and inhibits tumor formation .
23396362	0	PHLPP1	78,84	miR-190	52,59	PHLPP1	miR-190	23239	406965	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	NF-kB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1 .
25829425	0	PHLPP2	106,112	AKT	86,89	PHLPP2	AKT	23035	207	Gene	Gene	Suppression|nmod|START_ENTITY Suppression|compound|END_ENTITY	MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2 .
26868909	0	PHLPP2	66,72	C/EBP-b	21,28	PHLPP2	C/EBP-b	23035	1051	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Transcription factor C/EBP-b induces tumor-suppressor phosphatase PHLPP2 through repression of the miR-17-92 cluster in differentiating AML cells .
12232613	0	PHO2	43,47	PHO5	74,78	PHO2	PHO5	851452(Tax:4932)	852390(Tax:4932)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of Yeast Transcriptional Factor PHO2 on the Gene Expression of PHO5 , HIS4 and HO .
2664469	0	PHO4	55,59	PHO5	85,89	PHO4	PHO5	850594(Tax:4932)	852390(Tax:4932)	Gene	Gene	START_ENTITY|nmod|regions regions|nummod|END_ENTITY	The two positively acting regulatory proteins PHO2 and PHO4 physically interact with PHO5 upstream activation regions .
16407267	0	PHO5	79,83	Asf1	22,26	PHO5	Asf1	852390(Tax:4932)	853327(Tax:4932)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	The histone chaperone Asf1 increases the rate of histone eviction at the yeast PHO5 and PHO8 promoters .
22182244	0	PHO5	57,61	Ino2p	74,79	PHO5	Ino2p	852390(Tax:4932)	851701(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcription regulation of the Saccharomyces_cerevisiae PHO5 gene by the Ino2p and Ino4p basic helix-loop-helix proteins .
19596791	0	PHO5	116,120	Mcm1	124,128	PHO5	Mcm1	852390(Tax:4932)	855060(Tax:4932)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Coupling phosphate homeostasis to cell cycle-specific transcription : mitotic activation of Saccharomyces_cerevisiae PHO5 by Mcm1 and Forkhead proteins .
12232613	0	PHO5	74,78	PHO2	43,47	PHO5	PHO2	852390(Tax:4932)	851452(Tax:4932)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of Yeast Transcriptional Factor PHO2 on the Gene Expression of PHO5 , HIS4 and HO .
2664469	0	PHO5	85,89	PHO4	55,59	PHO5	PHO4	852390(Tax:4932)	850594(Tax:4932)	Gene	Gene	regions|nummod|START_ENTITY END_ENTITY|nmod|regions	The two positively acting regulatory proteins PHO2 and PHO4 physically interact with PHO5 upstream activation regions .
10801809	0	PHO5	87,91	PHO8	40,44	PHO5	PHO8	852390(Tax:4932)	852092(Tax:4932)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Transcriptional regulation of the yeast PHO8 promoter in comparison to the coregulated PHO5 promoter .
8948638	0	PHO5	109,113	Pho2	24,28	PHO5	Pho2	852390(Tax:4932)	851452(Tax:4932)	Gene	Gene	promoter|compound|START_ENTITY Pho4|nmod|promoter Pho4|nsubj|END_ENTITY	The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter .
7957054	0	PHO5	105,109	Pho4	59,63	PHO5	Pho4	852390(Tax:4932)	850594(Tax:4932)	Gene	Gene	promoter|compound|START_ENTITY site|nmod|promoter precludes|nmod|site precludes|dobj|END_ENTITY	A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter .
8948638	0	PHO5	109,113	Pho4	68,72	PHO5	Pho4	852390(Tax:4932)	850594(Tax:4932)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter .
9566882	0	PHO5	42,46	Pho4	84,88	PHO5	Pho4	852390(Tax:4932)	850594(Tax:4932)	Gene	Gene	promoter|compound|START_ENTITY interactions|nmod|promoter critical|nsubj|interactions critical|nmod|binding binding|nmod|END_ENTITY	Cooperative Pho2-Pho4 interactions at the PHO5 promoter are critical for binding of Pho4 to UASp1 and for efficient transactivation by Pho4 at UASp2 .
10801809	0	PHO8	40,44	PHO5	87,91	PHO8	PHO5	852092(Tax:4932)	852390(Tax:4932)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Transcriptional regulation of the yeast PHO8 promoter in comparison to the coregulated PHO5 promoter .
12174291	0	PHO85	34,39	PAP1	59,63	PHO85	PAP1	856076(Tax:4932)	853871(Tax:4932)	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Cloning and Expression of a Novel PHO85 Associated Protein PAP1 Gene of Saccharomyces_cerevisiae .
24850134	0	PHO92	18,23	Gcr1	40,44	PHO92	Gcr1	851980(Tax:4932)	856030(Tax:4932)	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	The expression of PHO92 is regulated by Gcr1 , and Pho92 is involved in glucose metabolism in Saccharomyces_cerevisiae .
25271326	0	PHOSPHATE_STARVATION_RESPONSE_1	43,74	SPX1	0,4	PHOSPHATE STARVATION RESPONSE 1	SPX1	828979(Tax:3702)	832137(Tax:3702)	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	SPX1 is a phosphate-dependent inhibitor of PHOSPHATE_STARVATION_RESPONSE_1 in Arabidopsis .
15024693	0	PHOX2B	51,57	paired-like_homeobox_2B	26,49	PHOX2B	paired-like homeobox 2B	8929	8929	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Germline mutations of the paired-like_homeobox_2B -LRB- PHOX2B -RRB- gene in neuroblastoma .
15949893	0	PHOX2B	51,57	paired-like_homeobox_2B	26,49	PHOX2B	paired-like homeobox 2B	8929	8929	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Germline mutations of the paired-like_homeobox_2B -LRB- PHOX2B -RRB- gene in neuroblastoma .
20156452	0	PHR	14,17	Phr1	44,48	PHR	Phr1	104151(Tax:10090)	105689(Tax:10090)	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Structures of PHR domains from Mus_musculus Phr1 -LRB- Mycbp2 -RRB- explain the loss-of-function mutation -LRB- Gly1092 -- > Glu -RRB- of the C. _ elegans ortholog RPM-1 .
12087061	0	PHS-2	38,43	prostaglandin_H_synthase-2	10,36	PHS-2	prostaglandin H synthase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Embryonic prostaglandin_H_synthase-2 -LRB- PHS-2 -RRB- expression and benzo -LSB- a -RSB- pyrene teratogenicity in PHS-2 knockout mice .
9068062	0	PHS-2	60,65	prostaglandin_endoperoxide_H_synthase-2	19,58	PHS-2	prostaglandin endoperoxide H synthase-2	5743	5743	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Induction of human prostaglandin_endoperoxide_H_synthase-2 -LRB- PHS-2 -RRB- mRNA by TCDD .
25865500	0	PHYTOCHROME-INTERACTING_FACTOR_1	120,152	HomeoBox_1	21,31	PHYTOCHROME-INTERACTING FACTOR 1	HomeoBox 1	816538(Tax:3702)	839740(Tax:3702)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Arabidopsis_thaliana HomeoBox_1 -LRB- AtHB1 -RRB- , a Homedomain-Leucine_Zipper_I -LRB- HD-Zip_I -RRB- transcription factor , is regulated by PHYTOCHROME-INTERACTING_FACTOR_1 to promote hypocotyl elongation .
17018862	0	PI-3	30,34	Bach2	112,117	PI-3	Bach2	5266	60468	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Bcr-Abl signaling through the PI-3 / S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2 , which represses the antiapoptotic factor heme_oxygenase-1 .
16574813	0	PI-3K	151,156	AKT	157,160	PI-3K	AKT	5293	207	Gene	Gene	progression|nmod|START_ENTITY progression|parataxis|END_ENTITY	Ganglioside_GM3 modulates tumor suppressor PTEN-mediated cell cycle progression -- transcriptional induction of p21 -LRB- WAF1 -RRB- and p27 -LRB- kip1 -RRB- by inhibition of PI-3K / AKT pathway .
21500175	0	PI-3K	0,5	AKT	6,9	PI-3K	AKT	5293	207	Gene	Gene	START_ENTITY|appos|vascular vascular|nsubj|modulates modulates|compound|END_ENTITY	PI-3K / AKT signal pathway modulates vascular smooth muscle cells migration under cyclic mechanical strain .
15067018	0	PI-3K	0,5	AP-1	31,35	PI-3K	AP-1	18708(Tax:10090)	16476(Tax:10090)	Gene	Gene	mediators|nsubj|START_ENTITY mediators|nmod|induction induction|compound|END_ENTITY	PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells .
20941752	0	PI-3K	42,47	AP-1	48,52	PI-3K	AP-1	5293	3727	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Silica induces cell cycle changes through PI-3K / AP-1 pathway in human embryo lung fibroblast cells .
15389633	0	PI-3K	0,5	Akt	6,9	PI-3K	Akt	5293	207	Gene	Gene	START_ENTITY|appos|activated activated|nsubjpass|pathways pathways|compound|END_ENTITY	PI-3K / Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment .
15550174	0	PI-3K	85,90	Akt	91,94	PI-3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K / Akt cell survival pathway .
16000874	0	PI-3K	44,49	Akt	50,53	PI-3K	Akt	5293	207	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	COX-2 inhibits anoikis by activation of the PI-3K / Akt pathway in human bladder_cancer cells .
16397275	9	PI-3K	1657,1662	Akt	1663,1666	PI-3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	It is likely that the inhibitory effects of fractions RO-FOO3 and RO-ME on B -LRB- a -RRB- PDE-induced AP-1 activation and VEGF expression are mediated by inhibition of the PI-3K / Akt pathway .
17370311	0	PI-3K	0,5	Akt	6,9	PI-3K	Akt	5293	207	Gene	Gene	START_ENTITY|appos|plays plays|nsubj|signal signal|compound|END_ENTITY	PI-3K / Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin_D1 .
17586659	0	PI-3K	137,142	Akt	143,146	PI-3K	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage : up-regulation of the PI-3K / Akt pathway .
18197291	0	PI-3K	0,5	Akt	6,9	PI-3K	Akt	5293	207	Gene	Gene	START_ENTITY|appos|responsible responsible|nsubj|expression expression|amod|END_ENTITY	PI-3K / Akt pathway-dependent cyclin_D1 expression is responsible for arsenite-induced human keratinocyte transformation .
18410948	0	PI-3K	96,101	Akt	102,105	PI-3K	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	cerebral_ischemic_injury|nmod|START_ENTITY neuroprotection|nmod|cerebral_ischemic_injury neuroprotection|parataxis|inhibiting inhibiting|nsubj|END_ENTITY	Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral_ischemic_injury via PI-3K / Akt pathway inhibiting the ASK1-JNK cascade .
18423117	0	PI-3K	20,25	Akt	26,29	PI-3K	Akt	5293	207	Gene	Gene	effect|nmod|START_ENTITY effect|parataxis|END_ENTITY	-LSB- Reversal effect of PI-3K / Akt pathway inhibitor LY294002 on multidrug resistance of ovarian_cancer cell line A2780/Taxol -RSB- .
18769058	0	PI-3K	64,69	Akt	70,73	PI-3K	Akt	5293	207	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Hemangiopoietin promotes endothelial cell proliferation through PI-3K / Akt pathway .
19887077	0	PI-3K	138,143	Akt	144,147	PI-3K	Akt	85243(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Brain-derived_neurotrophic_factor prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K / Akt pathways .
22928837	0	PI-3K	77,82	Akt	83,86	PI-3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production END_ENTITY|dep|inhibits	Pistacia chinensis inhibits NO production and upregulates HO-1 induction via PI-3K / Akt pathway in LPS stimulated macrophage cells .
15452053	0	PI-3K	60,65	Akt-1	66,71	PI-3K	Akt-1	5293	207	Gene	Gene	/|amod|START_ENTITY END_ENTITY|amod|/	HGF protects corneal epithelial cells from apoptosis by the PI-3K / Akt-1 / Bad - but not the ERK1/2-mediated signaling pathway .
16000874	0	PI-3K	44,49	COX-2	0,5	PI-3K	COX-2	5293	5743	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway inhibits|nmod|activation inhibits|nsubj|END_ENTITY	COX-2 inhibits anoikis by activation of the PI-3K / Akt pathway in human bladder_cancer cells .
9541596	0	PI-3K	59,64	Cbl	121,124	PI-3K	Cbl	5295	867	Gene	Gene	activation|nmod|START_ENTITY involves|nsubj|activation involves|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	CD16-mediated activation of phosphatidylinositol-3_kinase -LRB- PI-3K -RRB- in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2 , Shc , pp36 and p85 PI-3K subunit .
11222647	0	PI-3K	45,50	Erk1/2	89,95	PI-3K	Erk1/2	298947(Tax:10116)	50689;116590	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Activation of phosphatidylinositol-3 kinase -LRB- PI-3K -RRB- and extracellular regulated kinases -LRB- Erk1/2 -RRB- is involved in muscarinic receptor-mediated DNA synthesis in neural progenitor cells .
23831514	0	PI-3K	37,42	TFII-I	0,6	PI-3K	TFII-I	18708(Tax:10090)	14886(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TFII-I regulates target genes in the PI-3K and TGF-b signaling pathways through a novel DNA binding motif .
18197291	0	PI-3K	0,5	cyclin_D1	28,37	PI-3K	cyclin D1	5293	595	Gene	Gene	START_ENTITY|appos|responsible responsible|nsubj|expression expression|amod|END_ENTITY	PI-3K / Akt pathway-dependent cyclin_D1 expression is responsible for arsenite-induced human keratinocyte transformation .
20969943	0	PI-3K	104,109	eNOS	80,84	PI-3K	eNOS	298947(Tax:10116)	24600(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Chinese medicine Tongxinluo modulates vascular endothelial function by inducing eNOS expression via the PI-3K / Akt/HIF-dependent signaling pathway .
25418470	0	PI-3K	125,130	mTOR	131,135	PI-3K	mTOR	5290	21977(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interleukin-1_beta induces the expression and production of stem_cell_factor by epithelial cells : crucial involvement of the PI-3K / mTOR pathway and HIF-1 transcription complex .
9851866	0	PI-6	24,28	Proteinase_inhibitor_6	0,22	PI-6	Proteinase inhibitor 6	5269	5269	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Proteinase_inhibitor_6 -LRB- PI-6 -RRB- expression in human skin : induction of PI-6 and a PI-6 / proteinase complex during keratinocyte differentiation .
11485349	0	PI-9	26,30	granzyme_B	4,14	PI-9	granzyme B	5272	3002	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The granzyme_B inhibitor , PI-9 , is present in endothelial and mesothelial cells , suggesting that it protects bystander cells during immune responses .
11562487	0	PI-9	100,104	granzyme_B	16,26	PI-9	granzyme B	5272	3002	Gene	Gene	overexpression|nmod|START_ENTITY perforin|nmod|overexpression Blockade|dep|perforin Blockade|nmod|END_ENTITY	Blockade of the granzyme_B / perforin pathway through overexpression of the serine protease inhibitor PI-9 / SPI-6 constitutes a mechanism for immune escape by tumors .
15791691	0	PI-9	147,151	granzyme_B	72,82	PI-9	granzyme B	5272	3002	Gene	Gene	modulation|nmod|START_ENTITY Interaction|dep|modulation Interaction|nmod|END_ENTITY	Interaction of the nuclear localizing cytolytic granule serine protease granzyme_B with importin alpha or beta : modulation by the serpin inhibitor PI-9 .
16310039	0	PI-9	26,30	granzyme_B	4,14	PI-9	granzyme B	5272	3002	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The granzyme_B inhibitor , PI-9 , is differentially expressed during placental development and up-regulated in hydatidiform moles .
16487253	0	PI-9	63,67	granzyme_B	18,28	PI-9	granzyme B	5272	3002	Gene	Gene	inhibitor|appos|START_ENTITY proteinase|dobj|inhibitor proteinase|nsubj|Modulation Modulation|nmod|inhibitor inhibitor|amod|END_ENTITY	Modulation of the granzyme_B inhibitor proteinase inhibitor 9 -LRB- PI-9 -RRB- by activation of lymphocytes and monocytes in vitro and by Epstein-Barr_virus and bacterial_infection .
22533972	0	PI16	0,4	CCL17	78,83	PI16	CCL17	221476	6361	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20 .
23377702	0	PI3	9,12	Akt	16,19	PI3	Akt	408230(Tax:10116)	24185(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Impaired PI3 K Akt expression in liver and skeletal muscle of ovariectomized rats .
18518905	0	PI3-K	68,73	Insulin	0,7	PI3-K	Insulin	5293	3630	Gene	Gene	blocks|nmod|START_ENTITY blocks|nsubj|END_ENTITY	Insulin blocks cytochrome_c release in the reperfused brain through PI3-K signaling and by promoting Bax/Bcl-XL binding .
16289403	0	PI3-K	70,75	NR1	43,46	PI3-K	NR1	298947(Tax:10116)	24408(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	Electroacupuncture regulates NMDA receptor NR1 subunit expression via PI3-K pathway in a rat model of cerebral_ischemia-reperfusion .
19415692	0	PI3-K	79,84	Prolactin	0,9	PI3-K	Prolactin	5293	5617	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Prolactin induces chitotriosidase expression in human macrophages through PTK , PI3-K , and MAPK pathways .
10962556	0	PI3-K	58,63	phosphoinositide-3-OH_kinase	28,56	PI3-K	phosphoinositide-3-OH kinase	5295	5295	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Inhibition of EGFR-mediated phosphoinositide-3-OH_kinase -LRB- PI3-K -RRB- signaling and glioblastoma phenotype by signal-regulatory proteins -LRB- SIRPs -RRB- .
16202975	0	PI3-kinase	0,10	GM-CSF	25,31	PI3-kinase	GM-CSF	5296	1437	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	PI3-kinase activation by GM-CSF in endothelium is upstream of Jak/Stat pathway : role of alphaGMR .
15935772	0	PI3-kinase	41,51	Susi	0,4	PI3-kinase	Susi	33203(Tax:7227)	34767(Tax:7227)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Susi , a negative regulator of Drosophila PI3-kinase .
24770418	0	PI31	32,36	PSMF1	38,43	PI31	PSMF1	9491	9491	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Molecular and cellular roles of PI31 -LRB- PSMF1 -RRB- protein in regulation of proteasome function .
21035837	0	PI3K	107,111	AKT	113,116	PI3K	AKT	5293	207	Gene	Gene	kinase|appos|START_ENTITY pathway|dep|kinase pathway|compound|END_ENTITY	A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3 ' - kinase -LRB- PI3K -RRB- / AKT pathway in ovarian_cancer cells .
23408974	0	PI3K	40,44	AKT	73,76	PI3K	AKT	5290	207	Gene	Gene	pathway|compound|START_ENTITY alterations|nmod|pathway responsible|nsubj|alterations responsible|nmod|END_ENTITY	Multiple genetic alterations within the PI3K pathway are responsible for AKT activation in patients with ovarian_carcinoma .
23429328	0	PI3K	25,29	AKT	20,23	PI3K	AKT	5293	207	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
23814023	0	PI3K	19,23	AKT	56,59	PI3K	AKT	5293	207	Gene	Gene	inhibition|nmod|START_ENTITY mitigates|nsubj|inhibition mitigates|xcomp|activation activation|nsubj|END_ENTITY	Dual inhibition of PI3K and mTOR mitigates compensatory AKT activation and improves tamoxifen response in breast_cancer .
23867821	0	PI3K	71,75	AKT	16,19	PI3K	AKT	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	inhibitors|nummod|START_ENTITY cells|nmod|inhibitors treatment|nmod|cells signaling|nmod|treatment signaling|compound|END_ENTITY	Reactivation of AKT signaling following treatment of cancer cells with PI3K inhibitors attenuates their antitumor effects .
24425783	0	PI3K	26,30	AKT	57,60	PI3K	AKT	5293	207	Gene	Gene	signaling|compound|START_ENTITY signaling|appos|independent independent|nmod|END_ENTITY	BRAFV600E cooperates with PI3K signaling , independent of AKT , to regulate melanoma cell proliferation .
24482231	0	PI3K	84,88	AKT	90,93	PI3K	AKT	5293	207	Gene	Gene	phosphatidylinositide_3-Kinase|appos|START_ENTITY regulated|nmod|phosphatidylinositide_3-Kinase Cluster|acl|regulated Cluster|parataxis|signaling signaling|nsubj|END_ENTITY	Cluster of differentiation 166 -LRB- CD166 -RRB- regulated by phosphatidylinositide_3-Kinase -LRB- PI3K -RRB- / AKT signaling to exert its anti-apoptotic role via yes-associated_protein -LRB- YAP -RRB- in liver_cancer .
25100567	0	PI3K	22,26	AKT	29,32	PI3K	AKT	5293	207	Gene	Gene	PI3-kinase|appos|START_ENTITY Targeting|dobj|PI3-kinase axis|advcl|Targeting axis|nsubj|END_ENTITY	Targeting PI3-kinase -LRB- PI3K -RRB- , AKT and mTOR axis in lymphoma .
25424831	0	PI3K	42,46	AKT	0,3	PI3K	AKT	5290	207	Gene	Gene	mutations|nummod|START_ENTITY associated|nmod|mutations associated|nsubj|hyper-phosphorylation hyper-phosphorylation|compound|END_ENTITY	AKT hyper-phosphorylation associated with PI3K mutations in lymphatic endothelial cells from a patient with lymphatic_malformation .
25900077	0	PI3K	146,150	AKT	152,155	PI3K	AKT	5293	207	Gene	Gene	Phosphatidylinositol_3-Kinase|appos|START_ENTITY Proliferation|nmod|Phosphatidylinositol_3-Kinase Tone|nmod|Proliferation Tone|parataxis|Pathways Pathways|nsubj|END_ENTITY	A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / AKT and the Mammalian_Target_of_Rapamycin -LRB- MTOR -RRB- Pathways .
26895380	0	PI3K	53,57	AKT	59,62	PI3K	AKT	5293	207	Gene	Gene	coordinate|dobj|START_ENTITY coordinate|dep|growth growth|dep|END_ENTITY	Upregulated WDR26 serves as a scaffold to coordinate PI3K / AKT pathway-driven breast_cancer cell growth , migration , and invasion .
11788651	0	PI3K	56,60	Akt	86,89	PI3K	Akt	5295	207	Gene	Gene	activation|compound|START_ENTITY activation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Fatty_acid-induced insulin resistance : decreased muscle PI3K activation but unchanged Akt phosphorylation .
11842081	0	PI3K	35,39	Akt	41,44	PI3K	Akt	5293	207	Gene	Gene	3-kinase|appos|START_ENTITY 3-kinase|dep|Bax Bax|compound|END_ENTITY	The phosphatidylinositol 3-kinase -LRB- PI3K -RRB- - Akt pathway suppresses Bax translocation to mitochondria .
12875651	0	PI3K	35,39	Akt	41,44	PI3K	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphatidylinositol-3_kinase|appos|START_ENTITY phosphatidylinositol-3_kinase|dep|END_ENTITY	The phosphatidylinositol-3_kinase -LRB- PI3K -RRB- - Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells .
13679867	0	PI3K	46,50	Akt	70,73	PI3K	Akt	5293	207	Gene	Gene	inhibitors|nummod|START_ENTITY myelomas|nmod|inhibitors myelomas|nmod|pathway pathway|compound|END_ENTITY	Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway .
16007268	0	PI3K	0,4	Akt	48,51	PI3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	rescues|nsubj|START_ENTITY rescues|dobj|effects effects|nmod|activation activation|compound|END_ENTITY	PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury .
16380230	0	PI3K	56,60	Akt	113,116	PI3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|acl:relcl|mediated mediated|nmod|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces c-myc expression through a PI3K - and MAPK-dependent pathway that is not mediated by Akt , PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes .
16741926	0	PI3K	45,49	Akt	51,54	PI3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Regulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt and nuclear_factor-kappa_B signaling pathways in dystrophin-deficient_skeletal_muscle in response to mechanical stretch .
17170431	0	PI3K	139,143	Akt	81,84	PI3K	Akt	5295	207	Gene	Gene	subunit|nmod|START_ENTITY activates|nmod|subunit activates|dobj|pathway pathway|compound|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
17170431	0	PI3K	75,79	Akt	81,84	PI3K	Akt	5295	207	Gene	Gene	phosphatidylinositol_3-kinase|dep|START_ENTITY pathway|amod|phosphatidylinositol_3-kinase pathway|compound|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
17468516	0	PI3K	100,104	Akt	105,108	PI3K	Akt	5293	207	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Parathyroid_hormone-related_protein induces cell survival in human renal_cell_carcinoma through the PI3K Akt pathway : evidence for a critical role for integrin-linked_kinase and nuclear_factor_kappa_B .
18725974	0	PI3K	24,28	Akt	88,91	PI3K	Akt	5293	207	Gene	Gene	mutation|compound|START_ENTITY cells|nmod|mutation addicted|nsubjpass|cells addicted|nmod|signaling signaling|compound|END_ENTITY	Breast_tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling .
19009553	0	PI3K	42,46	Akt	48,51	PI3K	Akt	5295	207	Gene	Gene	c-Fos/c-Jun|compound|START_ENTITY c-Fos/c-Jun|dep|END_ENTITY	Ultrasound increased BMP-2 expression via PI3K , Akt , c-Fos/c-Jun , and AP-1 pathways in cultured osteoblasts .
19062713	0	PI3K	11,15	Akt	17,20	PI3K	Akt	5293	207	Gene	Gene	Impact|nmod|START_ENTITY Impact|dep|END_ENTITY	-LSB- Impact of PI3K / Akt / mdm2 signaling pathway on the sensitivity of gastric_cancer cell line SGC7901 to doxorubicin -RSB- .
19661335	0	PI3K	143,147	Akt	149,152	PI3K	Akt	5290	207	Gene	Gene	pathway|appos|START_ENTITY pathway|compound|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
19835871	0	PI3K	124,128	Akt	130,133	PI3K	Akt	5293	207	Gene	Gene	3-kinase|appos|START_ENTITY 3-kinase|dep|END_ENTITY	BMP2 accelerates the motility and invasiveness of gastric_cancer cells via activation of the phosphatidylinositol 3-kinase -LRB- PI3K -RRB- / Akt pathway .
23665174	0	PI3K	0,4	Akt	81,84	PI3K	Akt	5293	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|initiation initiation|nmod|epithelia epithelia|nmod|END_ENTITY	PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively .
23687303	0	PI3K	40,44	Akt	46,49	PI3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	phosphatidylinositol_3-kinase|appos|START_ENTITY Enhanced|dep|phosphatidylinositol_3-kinase Enhanced|parataxis|has has|nsubj|signaling signaling|compound|END_ENTITY	Enhanced phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress .
24338479	0	PI3K	55,59	Akt	61,64	PI3K	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	phosphatidylinositol_3-kinase|appos|START_ENTITY Manipulation|nmod|phosphatidylinositol_3-kinase Manipulation|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Manipulation of cardiac phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling by apoptosis_regulator_through_modulating_IAP_expression -LRB- ARIA -RRB- regulates cardiomyocyte_death during doxorubicin-induced cardiomyopathy .
26115885	0	PI3K	119,123	Akt	143,146	PI3K	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	/|appos|START_ENTITY B|compound|/ B|appos|END_ENTITY	Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / protein kinase B -LRB- Akt -RRB- signaling pathway .
26148798	0	PI3K	105,109	Akt	111,114	PI3K	Akt	5293	207	Gene	Gene	3-kinase|appos|START_ENTITY phosphoinositide|dobj|3-kinase phosphatase|dep|phosphoinositide END_ENTITY|nsubj|phosphatase	Small RNA profiling reveals deregulated phosphatase and tensin homolog -LRB- PTEN -RRB- / phosphoinositide 3-kinase -LRB- PI3K -RRB- / Akt pathway in bronchial smooth muscle cells from asthmatic patients .
26831566	0	PI3K	49,53	Akt	55,58	PI3K	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	Phosphatidylinositol_3_kinase|appos|START_ENTITY Phosphatidylinositol_3_kinase|dep|END_ENTITY	Icaritin requires Phosphatidylinositol_3_kinase -LRB- PI3K -RRB- / Akt signaling to counteract skeletal muscle_atrophy following mechanical unloading .
15833859	0	PI3K	51,55	BCR-ABL	0,7	PI3K	BCR-ABL	5293	25	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic_myelogenous_leukemia cells .
24709422	0	PI3K	23,27	BMX	0,3	PI3K	BMX	5293	660	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	BMX acts downstream of PI3K to promote colorectal_cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737 .
11842081	0	PI3K	35,39	Bax	64,67	PI3K	Bax	5293	581	Gene	Gene	3-kinase|appos|START_ENTITY 3-kinase|dep|END_ENTITY	The phosphatidylinositol 3-kinase -LRB- PI3K -RRB- - Akt pathway suppresses Bax translocation to mitochondria .
22905034	0	PI3K	16,20	CD4	42,45	PI3K	CD4	5293	920	Gene	Gene	Pathway|compound|START_ENTITY Pathway|nmod|END_ENTITY	The Role of the PI3K Signaling Pathway in CD4 -LRB- + -RRB- T Cell Differentiation and Function .
23429328	0	PI3K	25,29	CD40	8,12	PI3K	CD40	5293	958	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
17635516	0	PI3K	24,28	CDK2	0,4	PI3K	CDK2	298947(Tax:10116)	362817(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes .
17109853	0	PI3K	96,100	CHOP	119,123	PI3K	CHOP	5293	1649	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Inhibitory effect of 4 - -LRB- 2-aminoethyl -RRB- - benzenesulfonyl_fluoride , a serine protease inhibitor , on PI3K inhibitor-induced CHOP expression .
25683115	0	PI3K	112,116	CXCL16	149,155	PI3K	CXCL16	18708(Tax:10090)	66102(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Loss of Somatostatin-Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic_Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16 .
23733875	0	PI3K	68,72	Cyclooxygenase-2	0,16	PI3K	Cyclooxygenase-2	18708(Tax:10090)	19225(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY leads|nmod|signaling leads|nsubj|deficiency deficiency|amod|END_ENTITY	Cyclooxygenase-2 deficiency in macrophages leads to defective p110y PI3K signaling and impairs cell adhesion and migration .
20484116	0	PI3K	41,45	DAP10	55,60	PI3K	DAP10	5293	10870	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|END_ENTITY	TREM2 - and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1 .
16406609	0	PI3K	0,4	ERK1/2	63,69	PI3K	ERK1/2	5293	5595;5594	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation .
21387274	0	PI3K	118,122	ERK1/2	152,158	PI3K	ERK1/2	5293	5595;5594	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Limitations in small_intestinal_neuroendocrine_tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT .
26033591	0	PI3K	15,19	ERK1/2	26,32	PI3K	ERK1/2	5293	5595;5594	Gene	Gene	Involvement|nmod|START_ENTITY MAPK|nsubj|Involvement MAPK|dobj|END_ENTITY	Involvement of PI3K , MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine .
17716876	0	PI3K	0,4	ErbB	26,30	PI3K	ErbB	373752(Tax:8355)	724072(Tax:8355)	Gene	Gene	MAPK|nsubj|START_ENTITY MAPK|dobj|END_ENTITY	PI3K and Erk MAPK mediate ErbB signaling in Xenopus gastrulation .
18509048	0	PI3K	56,60	Foxp3	35,40	PI3K	Foxp3	5290	50943	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	T cell receptor signaling controls Foxp3 expression via PI3K , Akt , and mTOR .
23147208	0	PI3K	71,75	GSK-3b	96,102	PI3K	GSK-3b	85243(Tax:10116)	84027(Tax:10116)	Gene	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- induces proinsulin gene expression by activating PI3K : possible roles for GSK-3b and the transcriptional factor PDX-1 .
26093674	0	PI3K	0,4	GSK-3b	28,34	PI3K	GSK-3b	5293	2932	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	PI3K mediated activation of GSK-3b reduces at-level primary afferent growth responses associated with excitotoxic spinal_cord_injury dysesthesias .
27094789	0	PI3K	84,88	HIF1A	30,35	PI3K	HIF1A	5295	3091	Gene	Gene	activating|dobj|START_ENTITY induces|advcl|activating induces|dobj|expression expression|compound|END_ENTITY	Triiodothyronine -LRB- T3 -RRB- induces HIF1A and TGFA expression in MCF7 cells by activating PI3K .
21763292	0	PI3K	54,58	HO-1	34,38	PI3K	HO-1	18708(Tax:10090)	15368(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	b - adrenergic receptor-mediated HO-1 induction , via PI3K and p38_MAPK , by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice .
14534298	0	PI3K	106,110	IGF-1	54,59	PI3K	IGF-1	18708(Tax:10090)	16000(Tax:10090)	Gene	Gene	3-kinase|appos|START_ENTITY activation|nmod|3-kinase activation|appos|END_ENTITY	Beta-arrestin1 mediates insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- activation of phosphatidylinositol 3-kinase -LRB- PI3K -RRB- and anti-apoptosis .
16046480	0	PI3K	0,4	IGF-1	19,24	PI3K	IGF-1	5293	3479	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone .
24160342	0	PI3K	19,23	IGF-1	13,18	PI3K	IGF-1	298947(Tax:10116)	24482(Tax:10116)	Gene	Gene	pathway|nummod|START_ENTITY Role|dep|pathway Role|nmod|END_ENTITY	-LSB- Role of the IGF-1 / PI3K pathway and the molecular mechanism of Fuzhenghuayu therapy in a spontaneous recovery rat model of liver_fibrosis -RSB- .
24862866	0	PI3K	108,112	IGF-1	140,145	PI3K	IGF-1	298947(Tax:10116)	24482(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Oestrogen-dependent satellite cell activation and proliferation following a running exercise occurs via the PI3K signalling pathway and not IGF-1 .
18490721	0	PI3K	68,72	IL-2Rbeta	108,117	PI3K	IL-2Rbeta	5293	3560	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Late expression of granulysin by microbicidal CD4 + T cells requires PI3K - and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients .
25269483	0	PI3K	25,29	Kisspeptin	0,10	PI3K	Kisspeptin	18708(Tax:10090)	280287(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility .
19447101	0	PI3K	18,22	Kit	0,3	PI3K	Kit	18708(Tax:10090)	16590(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation .
19351816	0	PI3K	37,41	Kras	10,14	PI3K	Kras	18708(Tax:10090)	16653(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo .
15581426	0	PI3K	83,87	Leptin	0,6	PI3K	Leptin	18708(Tax:10090)	16846(Tax:10090)	Gene	Gene	reorganization|nummod|START_ENTITY stimulation|dep|reorganization stimulation|compound|END_ENTITY	Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones : PI3K dependent actin reorganization and KATP channel activation .
26023239	0	PI3K	53,57	Mammalian_Target_of_Rapamycin	60,89	PI3K	Mammalian Target of Rapamycin	5293	2475	Gene	Gene	Phosphatidylinositol_3-Kinase|appos|START_ENTITY Signaling|nmod|Phosphatidylinositol_3-Kinase mTOR|dep|Signaling mTOR|compound|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26023239	0	PI3K	53,57	Mammalian_Target_of_Rapamycin	60,89	PI3K	Mammalian Target of Rapamycin	5293	2475	Gene	Gene	Phosphatidylinositol_3-Kinase|appos|START_ENTITY Signaling|nmod|Phosphatidylinositol_3-Kinase mTOR|dep|Signaling mTOR|compound|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26101222	0	PI3K	50,54	Mammalian_Target_of_Rapamycin	56,85	PI3K	Mammalian Target of Rapamycin	5293	2475	Gene	Gene	Phosphoinositide_3-Kinase|appos|START_ENTITY Inhibition|nmod|Phosphoinositide_3-Kinase Inhibition|parataxis|Sensitizes Sensitizes|nsubj|END_ENTITY	Targeted Inhibition of Phosphoinositide_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Sensitizes Pancreatic_Cancer Cells to Doxorubicin without Exacerbating Cardiac_Toxicity .
24086481	0	PI3K	67,71	MiR-27a	0,7	PI3K	MiR-27a	5293	407018	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-27a regulates apoptosis in nucleus pulposus cells by targeting PI3K .
25727958	0	PI3K	148,152	Nrf2	77,81	PI3K	Nrf2	5294	4780	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways .
23939377	0	PI3K	0,4	PCNA	108,112	PI3K	PCNA	5293	5111	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA .
23893244	0	PI3K	23,27	PDK1	0,4	PI3K	PDK1	5293	5163	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	PDK1 controls upstream PI3K expression and PIP3 generation .
17475214	0	PI3K	0,4	PIK3IP1	32,39	PI3K	PIK3IP1	5293	113791	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	PI3K is negatively regulated by PIK3IP1 , a novel p110 interacting protein .
23676220	0	PI3K	101,105	PIK3IP1	127,134	PI3K	PIK3IP1	5293	113791	Gene	Gene	inhibition|compound|START_ENTITY cells|nmod|inhibition reprograms|dobj|cells reprograms|nmod|END_ENTITY	Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3K inhibition through PIK3IP1 .
16380231	0	PI3K	79,83	PKD	26,29	PI3K	PKD	5293	5587	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|activation activation|nmod|END_ENTITY	Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K , Vav1 and PLCgamma .
17468516	0	PI3K	100,104	Parathyroid_hormone-related_protein	0,35	PI3K	Parathyroid hormone-related protein	5293	5744	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	Parathyroid_hormone-related_protein induces cell survival in human renal_cell_carcinoma through the PI3K Akt pathway : evidence for a critical role for integrin-linked_kinase and nuclear_factor_kappa_B .
22767591	0	PI3K	31,35	Phosphatidylinositol_3-kinase	0,29	PI3K	Phosphatidylinositol 3-kinase	5293	5293	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Phosphatidylinositol_3-kinase -LRB- PI3K -RRB- activity bound to insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ receptor , which is continuously sustained by IGF-I stimulation , is required for IGF-I-induced cell proliferation .
25311989	0	PI3K	0,4	RAC1	19,23	PI3K	RAC1	18708(Tax:10090)	19353(Tax:10090)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice .
11803464	0	PI3K	57,61	Rac1	0,4	PI3K	Rac1	5293	5879	Gene	Gene	activation|nmod|START_ENTITY promote|nmod|activation promote|nsubj|END_ENTITY	Rac1 and RhoG promote cell survival by the activation of PI3K and Akt , independently of their ability to stimulate JNK and NF-kappaB .
21980400	0	PI3K	0,4	Rac1	21,25	PI3K	Rac1	5293	5879	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1a expression in MCF-7 breast_cancer cells .
25458846	0	PI3K	31,35	SGK3	0,4	PI3K	SGK3	5290	23678	Gene	Gene	Signaling|compound|START_ENTITY INPP4B-Dependent|dobj|Signaling INPP4B-Dependent|nsubj|Mediates Mediates|compound|END_ENTITY	SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast_Cancer .
25583802	0	PI3K	0,4	SGK3	56,60	PI3K	SGK3	5293	23678	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	PI3K Transduces AKT-Independent Oncogenic Signaling via SGK3 and INPP4B .
12791379	0	PI3K	19,23	SHIP1	38,43	PI3K	SHIP1	5293	3635	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases .
22733130	0	PI3K	0,4	SKP-2	23,28	PI3K	SKP-2	5293	6502	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	PI3K regulation of the SKP-2 / p27 axis through mTORC2 .
25056605	0	PI3K	93,97	Stanniocalcin-1	0,15	PI3K	Stanniocalcin-1	5293	6781	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Stanniocalcin-1 promotes metastasis in a human breast_cancer cell line through activation of PI3K .
20484116	0	PI3K	41,45	TREM2	0,5	PI3K	TREM2	5293	54209	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	TREM2 - and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1 .
23429328	0	PI3K	25,29	VEGF	14,18	PI3K	VEGF	5293	7422	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
22610277	0	PI3K	32,36	b-catenin	0,9	PI3K	b-catenin	5293	1499	Gene	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	b-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon_cancer .
23583404	0	PI3K	0,4	b-catenin	84,93	PI3K	b-catenin	5295	1499	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	PI3K is required for the physical interaction and functional inhibition of NF-kB by b-catenin in colorectal_cancer cells .
18495116	0	PI3K	61,65	bone_morphogenetic_protein-2	17,45	PI3K	bone morphogenetic protein-2	5295	650	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Naringin-induced bone_morphogenetic_protein-2 expression via PI3K , Akt , c-Fos/c-Jun and AP-1 pathway in osteoblasts .
12611639	0	PI3K	32,36	c-Met	10,15	PI3K	c-Met	5293	4233	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small_cell_lung_cancer .
18927440	0	PI3K	26,30	c-Rel	35,40	PI3K	c-Rel	18708(Tax:10090)	19696(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Critical role of class IA PI3K for c-Rel expression in B lymphocytes .
25090459	0	PI3K	32,36	cMET	10,14	PI3K	cMET	5293	4233	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal_cancers independent of KRAS mutational status .
17341442	0	PI3K	69,73	cyclooxygenase-2	37,53	PI3K	cyclooxygenase-2	5293	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor-I induces cyclooxygenase-2 expression via PI3K , MAPK and PKC signaling pathways in human ovarian_cancer cells .
18220263	0	PI3K	120,124	eNOS	86,90	PI3K	eNOS	5293	4846	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	Low-energy laser irradiation increases endothelial cell proliferation , migration , and eNOS gene expression possibly via PI3K signal pathway .
18511807	0	PI3K	16,20	hTERT	54,59	PI3K	hTERT	5293	7015	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|nmod|END_ENTITY	Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells .
18554677	0	PI3K	130,134	heme_oxygenase-1	108,124	PI3K	heme oxygenase-1	5293	3162	Gene	Gene	manner|compound|START_ENTITY END_ENTITY|nmod|manner	Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme_oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner .
25269483	0	PI3K	25,29	kisspeptin	63,73	PI3K	kisspeptin	18708(Tax:10090)	280287(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling regulates|dobj|expression expression|compound|END_ENTITY	Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility .
22880054	0	PI3K	39,43	latent_membrane_protein_1	68,93	PI3K	latent membrane protein 1	5293	9260	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	Src kinase and Syk activation initiate PI3K signaling by a chimeric latent_membrane_protein_1 in Epstein-Barr_virus -LRB- EBV -RRB- + B cell lymphomas .
11748924	0	PI3K	23,27	leptin	6,12	PI3K	leptin	5295	3952	Gene	Gene	pathways|compound|START_ENTITY activates|dobj|pathways activates|nsubj|END_ENTITY	Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells : possible role of Sam68 .
17229473	0	PI3K	8,12	leptin	72,78	PI3K	leptin	298947(Tax:10116)	25608(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin .
21085763	0	PI3K	4,8	leptin	62,68	PI3K	leptin	5293	3952	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	The PI3K signaling pathway mediates the biological effects of leptin .
21270124	0	PI3K	100,104	leptin	152,158	PI3K	leptin	298947(Tax:10116)	25608(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|xcomp|signaling signaling|dobj|pathways pathways|dep|implications implications|nmod|END_ENTITY	Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways : implications for leptin as a regulator of short term satiety .
21270124	0	PI3K	100,104	leptin	32,38	PI3K	leptin	298947(Tax:10116)	25608(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|interaction interaction|nmod|END_ENTITY	Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways : implications for leptin as a regulator of short term satiety .
24058635	0	PI3K	96,100	leptin	44,50	PI3K	leptin	18708(Tax:10090)	16846(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY adipocytes|nmod|activation time|nmod|adipocytes increases|nmod|time increases|dobj|levels levels|compound|END_ENTITY	Triiodothyronine increases mRNA and protein leptin levels in short time in 3T3-L1 adipocytes by PI3K pathway activation .
23089982	0	PI3K	0,4	mTORC1	31,37	PI3K	mTORC1	5293	382056(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2 + breast_cancer cells .
23326514	0	PI3K	118,122	mTORC1	30,36	PI3K	mTORC1	18708(Tax:10090)	382056(Tax:10090)	Gene	Gene	prevents|nmod|START_ENTITY prevents|nsubj|inhibition inhibition|nmod|END_ENTITY	Pharmacological inhibition of mTORC1 prevents over-activation of the primordial follicle pool in response to elevated PI3K signaling .
26028026	0	PI3K	10,14	mTORC1	67,73	PI3K	mTORC1	5293	382056(Tax:10090)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|synthesis synthesis|nmod|END_ENTITY	Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP .
26159692	0	PI3K	24,28	mTORC1	14,20	PI3K	mTORC1	5295	382056(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY Regulation|nmod|signaling Regulation|nmod|END_ENTITY	Regulation of mTORC1 by PI3K signaling .
20522531	0	PI3K	102,106	mammalian_target_of_rapamycin	52,81	PI3K	mammalian target of rapamycin	5290	2475	Gene	Gene	signaling|compound|START_ENTITY prevents|dobj|signaling prevents|nsubj|WJD008 WJD008|appos|inhibitor inhibitor|compound|END_ENTITY	WJD008 , a dual phosphatidylinositol 3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin inhibitor , prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant .
20522531	0	PI3K	46,50	mammalian_target_of_rapamycin	52,81	PI3K	mammalian target of rapamycin	5290	2475	Gene	Gene	3-kinase|dep|START_ENTITY inhibitor|amod|3-kinase inhibitor|compound|END_ENTITY	WJD008 , a dual phosphatidylinositol 3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin inhibitor , prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant .
20797855	0	PI3K	67,71	mammalian_target_of_rapamycin	73,102	PI3K	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
21714526	0	PI3K	63,67	mammalian_target_of_rapamycin	69,98	PI3K	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships of phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors : investigations of various 6,5-heterocycles to improve metabolic stability .
26298499	0	PI3K	96,100	mammalian_target_of_rapamycin	102,131	PI3K	mammalian target of rapamycin	5293	2475	Gene	Gene	/|appos|START_ENTITY scaffold|nmod|/ END_ENTITY|amod|scaffold	The imidazo -LSB- 1,2-a -RSB- pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors .
21515581	0	PI3K	63,67	metabotropic_glutamate_receptor	4,35	PI3K	metabotropic glutamate receptor	33203(Tax:7227)	43838(Tax:7227)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The metabotropic_glutamate_receptor activates the lipid kinase PI3K in Drosophila motor neurons through the calcium/calmodulin-dependent protein kinase II and the nonreceptor tyrosine protein kinase DFak .
20307615	0	PI3K	54,58	moesin	12,18	PI3K	moesin	298947(Tax:10116)	81521(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	NGF-induced moesin phosphorylation is mediated by the PI3K , Rac1 and Akt and required for neurite formation in PC12 cells .
15625017	0	PI3K	62,66	neu	49,52	PI3K	neu	5293	2064	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Downregulation of wild-type p53 protein by HER-2 / neu mediated PI3K pathway activation in human breast_cancer cells : its effect on cell proliferation and implication for therapy .
19572978	0	PI3K	37,41	p21	15,18	PI3K	p21	5293	644914	Gene	Gene	activation|nummod|START_ENTITY END_ENTITY|nmod|activation	DIXDC1 targets p21 and cyclin_D1 via PI3K pathway activation to promote colon_cancer cell proliferation .
15363324	0	PI3K	74,78	p53	47,50	PI3K	p53	5293	7157	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	-LSB- Overexpression of HER2/neu downregulates wild p53 protein expression via PI3K and Ras/Raf/MEK / ERK pathways in human breast_cancer cells -RSB- .
15625017	0	PI3K	62,66	p53	28,31	PI3K	p53	5293	7157	Gene	Gene	activation|amod|START_ENTITY Downregulation|dep|activation Downregulation|nmod|protein protein|compound|END_ENTITY	Downregulation of wild-type p53 protein by HER-2 / neu mediated PI3K pathway activation in human breast_cancer cells : its effect on cell proliferation and implication for therapy .
17329971	0	PI3K	10,14	p53	53,56	PI3K	p53	5290	7157	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|inducer inducer|nmod|END_ENTITY	Activated PI3K signaling as an endogenous inducer of p53 in human cancer .
26311153	0	PI3K	89,93	p53	139,142	PI3K	p53	5293	7157	Gene	Gene	phosphatidylinositol_3-kinase|appos|START_ENTITY downregulation|nmod|phosphatidylinositol_3-kinase downregulation|nmod|induction induction|nmod|END_ENTITY	Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- and protein kinase C -LRB- PKC -RRB- via induction of p53 in hepatocellular_carcinoma -LRB- HepG2 -RRB- cell line .
17043656	0	PI3K	30,34	p85	4,7	PI3K	p85	5295	5295	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals .
17170431	0	PI3K	139,143	p85	124,127	PI3K	p85	5295	5296	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
24651434	0	PI3K	80,84	p85	54,57	PI3K	p42	5293	23552	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP .
25114970	0	PI3K	30,34	p85	4,7	PI3K	p85	5295	5295	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility .
19304514	0	PI3K	1,5	p85alpha	6,14	PI3K	p85alpha	5295	5295	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	-LSB- PI3K p85alpha expression and its role in the progression of colorectal_cancer -RSB- .
20007249	0	PI3K	143,147	p85alpha	112,120	PI3K	p85alpha	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Reduced T cell expansion by a superantigen as a result of impaired B cell development in mice deficient for the p85alpha regulatory subunit of PI3K .
23813545	0	PI3K	57,61	phosphatidylinositide_3-kinase	25,55	PI3K	phosphatidylinositide 3-kinase	5290	5290	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Molecular changes in the phosphatidylinositide_3-kinase -LRB- PI3K -RRB- pathway are common in gastric_cancer .
16882036	0	PI3K	52,56	phosphatidylinositol-3-kinase	21,50	PI3K	phosphatidylinositol-3-kinase	5293	5293	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Bivalent role of the phosphatidylinositol-3-kinase -LRB- PI3K -RRB- during influenza_virus_infection and host cell defence .
20797855	0	PI3K	67,71	phosphatidylinositol-3-kinase	36,65	PI3K	phosphatidylinositol-3-kinase	5293	5293	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
12533781	0	PI3K	43,47	phosphatidylinositol_3-kinase	12,41	PI3K	phosphatidylinositol 3-kinase	5293	5293	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- in CO2 stimulation of the Na + / HCO3 - _ cotransporter -LRB- NBC -RRB- .
16741926	0	PI3K	45,49	phosphatidylinositol_3-kinase	14,43	PI3K	phosphatidylinositol 3-kinase	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Regulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt and nuclear_factor-kappa_B signaling pathways in dystrophin-deficient_skeletal_muscle in response to mechanical stretch .
19661335	0	PI3K	143,147	phosphatidylinositol_3-kinase	112,141	PI3K	phosphatidylinositol 3-kinase	5290	5290	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
19919182	0	PI3K	57,61	phosphatidylinositol_3-kinase	26,55	PI3K	phosphatidylinositol 3-kinase	5293	5293	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Structural studies of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- SH3 domain in complex with a peptide ligand : role of the anchor residue in ligand binding .
21723579	0	PI3K	77,81	phosphatidylinositol_3-kinase	46,75	PI3K	phosphatidylinositol 3-kinase	5295	5295	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Infectious_bursal_disease_virus activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling pathway by interaction of VP5 protein with the p85a subunit of PI3K .
21903247	0	PI3K	47,51	phosphatidylinositol_3-kinase	16,45	PI3K	phosphatidylinositol 3-kinase	5290	5290	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	The role of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- pathway in the development and treatment of uterine cancer .
22929971	0	PI3K	47,51	phosphatidylinositol_3-kinase	16,45	PI3K	phosphatidylinositol 3-kinase	5290	5290	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	HS-173 , a novel phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis .
24361696	0	PI3K	52,56	phosphatidylinositol_3-kinase	21,50	PI3K	phosphatidylinositol 3-kinase	5293	5293	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	DW09849 , a selective phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110a -LRB- H1047R -RRB- .
21714526	0	PI3K	63,67	phosphoinositide_3-kinase	36,61	PI3K	phosphoinositide 3-kinase	5293	5293	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships of phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors : investigations of various 6,5-heterocycles to improve metabolic stability .
21953448	0	PI3K	215,219	phosphoinositide_3-kinase	188,213	PI3K	phosphoinositide 3-kinase	5293	5293	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Hydrogen_sulfide and L-cysteine increase phosphatidylinositol_3 ,4,5 - trisphosphate -LRB- PIP3 -RRB- and glucose utilization by inhibiting phosphatase and tensin homolog -LRB- PTEN -RRB- protein and activating phosphoinositide_3-kinase -LRB- PI3K -RRB- / serine/threonine protein kinase -LRB- AKT -RRB- / protein kinase C / -LRB- PKC / -RRB- in 3T3l1 adipocytes .
22905224	0	PI3K	96,100	phosphoinositide_3-kinase	69,94	PI3K	phosphoinositide 3-kinase	5293	5293	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide_3-kinase -LRB- PI3K -RRB- inhibitors .
26236186	0	PI3K	83,87	phosphoinositide_3-kinase	56,81	PI3K	phosphoinositide 3-kinase	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Shiga toxin type-2 -LRB- Stx2 -RRB- induces glutamate release via phosphoinositide_3-kinase -LRB- PI3K -RRB- pathway in murine neurons .
17008542	0	PI3K	0,4	pleckstrin-2	15,27	PI3K	pleckstrin-2	5290	26499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization .
18398001	0	PI3K	38,42	thrombin	11,19	PI3K	thrombin	18708(Tax:10090)	14061(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells .
22187460	0	PI3K/Akt	126,134	B-cell_adapter_for_PI3K	9,32	PI3K/Akt	B-cell adapter for PI3K	5293;207	118788	Gene	Gene	kinases|dobj|START_ENTITY kinases|nsubj|Role Role|nmod|END_ENTITY	Role for B-cell_adapter_for_PI3K -LRB- BCAP -RRB- as a signaling adapter linking Toll-like receptors -LRB- TLRs -RRB- to serine/threonine kinases PI3K/Akt .
24969300	0	PI3KR2_and_Crk	85,99	Mir-126	0,7	PI3KR2 and Crk	Mir-126	1398	406913	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Mir-126 inhibits growth of SGC-7901 cells by synergistically targeting the oncogenes PI3KR2_and_Crk , and the tumor suppressor PLK2 .
19660434	0	PI3Kgamma	0,9	CXCL12	24,30	PI3Kgamma	CXCL12	5294	6387	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	PI3Kgamma activation by CXCL12 regulates tumor cell adhesion and invasion .
18542100	0	PI3Kgamma	45,54	phosphatidylinositol-3-kinase-gamma	8,43	PI3Kgamma	phosphatidylinositol-3-kinase-gamma	30955(Tax:10090)	30955(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of phosphatidylinositol-3-kinase-gamma -LRB- PI3Kgamma -RRB- - mediated pathway in 17beta-estradiol-induced killing of L. mexicana in macrophages from C57BL/6 mice .
18512147	0	PI3_K	102,107	Akt	108,111	PI3 K	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Enhanced survival of melanopsin-expressing retinal ganglion cells after injury is associated with the PI3_K / Akt pathway .
25621554	0	PI3_Kinase	113,123	Akt	124,127	PI3 Kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Different Concentrations of Glucose Regulate Proliferation and Osteogenic Differentiation of Osteoblasts Via the PI3_Kinase / Akt Pathway .
20203419	0	PI3_kinase	139,149	Akt	150,153	PI3 kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	4-Methylcatechol-induced heme_oxygenase-1 exerts a protective effect against oxidative stress in cultured neural stem/progenitor cells via PI3_kinase / Akt pathway .
21109949	0	PI3_kinase	0,10	Akt	22,25	PI3 kinase	Akt	5293	207	Gene	Gene	integrates|nsubj|START_ENTITY integrates|xcomp|signaling signaling|nsubj|END_ENTITY	PI3_kinase integrates Akt and MAP kinase signaling pathways in the regulation of prostate_cancer .
24634221	0	PI3k	45,49	Akt	51,54	PI3k	Akt	5295	207	Gene	Gene	3-kinase|appos|START_ENTITY 3-kinase|dep|signaling signaling|compound|END_ENTITY	Role of c-Met/phosphatidylinositol _ 3-kinase -LRB- PI3k -RRB- / Akt signaling in hepatocyte_growth_factor -LRB- HGF -RRB- - mediated lamellipodia formation , reactive oxygen species -LRB- ROS -RRB- generation , and motility of lung endothelial cells .
26919096	0	PI3k	121,125	c-Met	114,119	PI3k	c-Met	5293	4233	Gene	Gene	Akt/mTOR|dep|START_ENTITY Akt/mTOR|amod|END_ENTITY	MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung_cancer via c-Met / PI3k / Akt/mTOR pathway .
7665170	0	PI7	44,47	thrombin	24,32	PI7	thrombin	5270	2147	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The gene for the serpin thrombin inhibitor -LRB- PI7 -RRB- , protease_nexin_I , is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes .
18083234	0	PIAS1	36,41	AIRE	26,30	PIAS1	AIRE	8554	326	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of AIRE with PIAS1 in transcriptional regulation .
22406621	0	PIAS1	19,24	PML	56,59	PIAS1	PML	8554	5371	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA .
26911452	0	PIAS1	43,48	PRMT1	23,28	PIAS1	PRMT1	8554	3276	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung_inflammation .
27032383	0	PIAS1	0,5	p300	12,16	PIAS1	p300	8554	2033	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status .
22969086	0	PIAS1	49,54	protein_inhibitor_of_activated_STAT1	11,47	PIAS1	protein inhibitor of activated STAT1	56469(Tax:10090)	56469(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for protein_inhibitor_of_activated_STAT1 -LRB- PIAS1 -RRB- in lipogenic regulation through SUMOylation-independent suppression of liver X receptors .
22210188	0	PIAS2	54,59	protein_inhibitor_of_activated_STAT_2	15,52	PIAS2	protein inhibitor of activated STAT 2	9063	9063	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of protein_inhibitor_of_activated_STAT_2 -LRB- PIAS2 -RRB- with receptor_of_activated_C_kinase_1 , RACK1 .
22210188	0	PIAS2	54,59	receptor_of_activated_C_kinase_1	66,98	PIAS2	receptor of activated C kinase 1	9063	10399	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of protein_inhibitor_of_activated_STAT_2 -LRB- PIAS2 -RRB- with receptor_of_activated_C_kinase_1 , RACK1 .
17565989	0	PIAS3	0,5	ATF1	21,25	PIAS3	ATF1	10401	466	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element .
26697750	0	PIAS3	0,5	HIF-1a	47,53	PIAS3	HIF-1a	10401	3091	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	PIAS3 enhances the transcriptional activity of HIF-1a by increasing its protein stability .
22584572	0	PIAS3	38,43	Protein_inhibitor_of_activated_STAT3	0,36	PIAS3	Protein inhibitor of activated STAT3	10401	10401	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Protein_inhibitor_of_activated_STAT3 -LRB- PIAS3 -RRB- protein promotes SUMOylation and nuclear sequestration of the intracellular_domain of ErbB4 protein .
11060035	0	PIAS3	98,103	STAT3	42,47	PIAS3	STAT3	10401	6774	Gene	Gene	interacting|nmod|START_ENTITY signaling|advcl|interacting END_ENTITY|acl|signaling	The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3 .
11709556	0	PIAS3	36,41	STAT3	19,24	PIAS3	STAT3	83614(Tax:10116)	25125(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A new role for the STAT3 inhibitor , PIAS3 : a repressor of microphthalmia_transcription_factor .
14715251	0	PIAS3	70,75	STAT3	34,39	PIAS3	STAT3	10401	6774	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3 .
18581899	0	PIAS3	15,20	STAT3	47,52	PIAS3	STAT3	10401	6774	Gene	Gene	START_ENTITY|dobj|inhibitor inhibitor|nmod|protein protein|compound|END_ENTITY	-LSB- Expression of PIAS3 an inhibitor of activated STAT3 protein in human prostate_cancer -RSB- .
20371673	0	PIAS3	86,91	STAT3	101,106	PIAS3	STAT3	10401	6774	Gene	Gene	domain|nmod|START_ENTITY derived|nmod|domain peptide|acl|derived delivery|nmod|peptide inhibits|nsubj|delivery inhibits|dobj|transactivation transactivation|compound|END_ENTITY	The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death .
20516148	0	PIAS3	62,67	STAT3	16,21	PIAS3	STAT3	229615(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY modulates|nmod|regulation modulates|dobj|activity activity|compound|END_ENTITY	TRIM8 modulates STAT3 activity through negative regulation of PIAS3 .
21812053	0	PIAS3	20,25	STAT3	79,84	PIAS3	STAT3	10401	6774	Gene	Gene	domain|nmod|START_ENTITY domain|dep|analysis analysis|nmod|interaction interaction|nmod|END_ENTITY	The PINIT domain of PIAS3 : structure-function analysis of its interaction with STAT3 .
23322197	0	PIAS3	69,74	STAT3	23,28	PIAS3	STAT3	10401	6774	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis .
24718277	0	PIAS3	0,5	STAT3	115,120	PIAS3	STAT3	229615(Tax:10090)	20848(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|xcomp|acute_graft-versus-host_disease acute_graft-versus-host_disease|advcl|modulating modulating|nmod|inhibition inhibition|nmod|activation activation|compound|END_ENTITY	PIAS3 suppresses acute_graft-versus-host_disease by modulating effector T and B cell subsets through inhibition of STAT3 activation .
24857987	0	PIAS3	55,60	STAT3	35,40	PIAS3	STAT3	10401	6774	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Down-regulation of ATBF1 activates STAT3 signaling via PIAS3 in pacing-induced HL-1 atrial myocytes .
25124686	0	PIAS3	4,9	STAT3	76,81	PIAS3	STAT3	10401	6774	Gene	Gene	Expression|compound|START_ENTITY Associated|nsubj|Expression Associated|nmod|Activation Activation|compound|END_ENTITY	Low PIAS3 Expression in Malignant_Mesothelioma Is Associated with Increased STAT3 Activation and Poor Patient Survival .
25624051	0	PIAS3	157,162	STAT3	108,113	PIAS3	STAT3	10401	6774	Gene	Gene	induction|nmod|START_ENTITY signaling|nmod|induction signaling|nsubj|END_ENTITY	Ascochlorin , an isoprenoid antibiotic inhibits growth and invasion of hepatocellular_carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3 .
25785044	0	PIAS3	0,5	STAT3	23,28	PIAS3	STAT3	10401	6774	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	PIAS3 , an inhibitor of STAT3 , has intensively negative association with the survival of gastric_cancer .
26432044	0	PIAS3	0,5	STAT3	128,133	PIAS3	STAT3	10401	6774	Gene	Gene	patterns|compound|START_ENTITY patterns|dep|Relevance Relevance|nmod|inactivation inactivation|nmod|signaling signaling|compound|END_ENTITY	PIAS3 , SHP2 and SOCS3 expression patterns in cervical_cancers : Relevance with activation and resveratrol-caused inactivation of STAT3 signaling .
9388184	0	PIAS3	52,57	Stat3	23,28	PIAS3	Stat3	10401	6774	Gene	Gene	transduction|nmod|START_ENTITY transduction|nsubj|inhibition inhibition|nmod|signal signal|amod|END_ENTITY	Specific inhibition of Stat3 signal transduction by PIAS3 .
11429412	0	PIAS3	193,198	estrogen_receptor	140,157	PIAS3	estrogen receptor	10401	2099	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Activation of estrogen_receptor blocks interleukin-6-inducible cell growth of human multiple_myeloma involving molecular cross-talk between estrogen_receptor and STAT3 mediated by co-regulator PIAS3 .
16148010	0	PIASxalpha	34,44	FLI-1	0,5	PIASxalpha	FLI-1	9063	2313	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	FLI-1 functionally interacts with PIASxalpha , a member of the PIAS E3 SUMO ligase family .
17623776	0	PIASxbeta	0,9	osterix	32,39	PIASxbeta	osterix	17344(Tax:10090)	170574(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts .
19067654	0	PIASy	0,5	CYP11A1	31,38	PIASy	CYP11A1	51588	1583	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	PIASy inhibits LRH-1-dependent CYP11A1 expression by competing for SRC-1 binding .
24614299	0	PIASy	42,47	Tomosyn	0,7	PIASy	Tomosyn	51588	134957	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tomosyn interacts with the SUMO E3 ligase PIASy .
22829926	0	PIASy	37,42	a-smooth_muscle_actin	53,74	PIASy	a-smooth muscle actin	51588	58	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Protein inhibitor of activated STAT , PIASy regulates a-smooth_muscle_actin expression by interacting with E12 in mesangial cells .
21755480	0	PIBF	1,5	Progesterone-Induced_Blocking_Factor	8,44	PIBF	Progesterone-Induced Blocking Factor	10464	10464	Gene	Gene	START_ENTITY|dep|-RSB- -RSB-|compound|END_ENTITY	-LSB- PIBF - Progesterone-Induced_Blocking_Factor -RSB- .
17218258	0	PICH	0,4	Plk1	66,70	PICH	Plk1	54821	5347	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	PICH , a centromere-associated SNF2 family ATPase , is regulated by Plk1 and required for the spindle checkpoint .
24723684	0	PICK1	0,5	Argonaute_2	12,23	PICK1	Argonaute 2	9463	27161	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	PICK1 links Argonaute_2 to endosomes in neuronal_dendrites and regulates miRNA activity .
25475687	0	PICK1	0,5	Cdc42	41,46	PICK1	Cdc42	9463	998	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	PICK1 links AMPA receptor stimulation to Cdc42 .
22275068	0	PICK1	70,75	PDZ	56,59	PICK1	PDZ	9463	7082	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The binding affinities of proteins interacting with the PDZ domain of PICK1 .
18755154	0	PICK1	0,5	calcineurin_B	15,28	PICK1	calcineurin B	84591(Tax:10116)	5534	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	PICK1 binds to calcineurin_B and modulates the NFAT activity in PC12 cells .
18077702	0	PICK1	0,5	glutamate_receptor_2	33,53	PICK1	glutamate receptor 2	9463	2891	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
11802773	0	PICK1	36,41	protein_interacting_with_C_kinase_1	43,78	PICK1	protein interacting with C kinase 1	9463	9463	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the synaptic protein PICK1 -LRB- protein_interacting_with_C_kinase_1 -RRB- with the non-voltage gated sodium channels BNC1 -LRB- brain Na + channel 1 -RRB- and ASIC -LRB- acid-sensing_ion_channel -RRB- .
10570159	0	PICKLE	0,6	CHD3	12,16	PICKLE	CHD3	817055(Tax:3702)	817055(Tax:3702)	Gene	Gene	factor|nsubj|START_ENTITY factor|compound|END_ENTITY	PICKLE is a CHD3 chromatin-remodeling factor that regulates the transition from embryonic to vegetative development in Arabidopsis .
23615448	0	PICOT	47,52	glutaredoxin_3	31,45	PICOT	glutaredoxin 3	10539	10539	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Crucial function of vertebrate glutaredoxin_3 -LRB- PICOT -RRB- in iron homeostasis and hemoglobin maturation .
21804542	0	PICT1	55,60	RPL11	75,80	PICT1	RPL11	29997	6135	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 .
23532381	0	PICT1	25,30	TP53	86,90	PICT1	TP53	29997	7157	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of PICT1 in patients of hepatocellular_carcinoma with wild-type TP53 .
24045667	0	PICT1	0,5	TP53	16,20	PICT1	TP53	29997	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PICT1 regulates TP53 via RPL11 and is involved in gastric_cancer progression .
20165904	0	PID1	26,30	NYGGF4	18,24	PID1	NYGGF4	55022	55022	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of NYGGF4 -LRB- PID1 -RRB- induces mitochondrial_impairment in 3T3-L1 adipocytes .
23237778	0	PID1	98,102	phosphotyrosine_interaction_domain_containing_1	49,96	PID1	phosphotyrosine interaction domain containing 1	102171387	102171387	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning and tissue distribution of the phosphotyrosine_interaction_domain_containing_1 -LRB- PID1 -RRB- gene in Tianfu goat .
12837955	0	PIE1	0,4	FLC	43,46	PIE1	FLC	820463(Tax:3702)	830878(Tax:3702)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	PIE1 , an ISWI family gene , is required for FLC activation and floral repression in Arabidopsis .
17142478	0	PIE1	84,88	SEF	0,3	PIE1	SEF	820463(Tax:3702)	833676(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SEF , a new protein required for flowering repression in Arabidopsis , interacts with PIE1 and ARP6 .
12966435	0	PIF	108,111	proteolysis-inducing_factor	79,106	PIF	proteolysis-inducing factor	100126829(Tax:10090)	100126829(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing_factor -LRB- PIF -RRB- is associated with activation of the transcription factor NF-kappaB .
24179122	0	PIF1	16,20	HFR1	0,4	PIF1	HFR1	816538(Tax:3702)	839300(Tax:3702)	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	HFR1 sequesters PIF1 to govern the transcriptional network underlying light-initiated seed germination in Arabidopsis .
24420574	0	PIF1	0,4	PIF3	103,107	PIF1	PIF3	816538(Tax:3702)	837479(Tax:3702)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	PIF1 promotes phytochrome-regulated growth under photoperiodic conditions in Arabidopsis together with PIF3 , PIF4 , and PIF5 .
24420574	0	PIF3	103,107	PIF1	0,4	PIF3	PIF1	837479(Tax:3702)	816538(Tax:3702)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	PIF1 promotes phytochrome-regulated growth under photoperiodic conditions in Arabidopsis together with PIF3 , PIF4 , and PIF5 .
11069292	0	PIF3	107,111	Phytochrome_B	0,13	PIF3	Phytochrome B	837479(Tax:3702)	816394(Tax:3702)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Phytochrome_B binds with greater apparent affinity than phytochrome A to the basic helix-loop-helix factor PIF3 in a reaction requiring the PAS domain of PIF3 .
11069292	0	PIF3	154,158	Phytochrome_B	0,13	PIF3	Phytochrome B	837479(Tax:3702)	816394(Tax:3702)	Gene	Gene	domain|nmod|START_ENTITY requiring|dobj|domain reaction|acl|requiring PIF3|nmod|reaction binds|nmod|PIF3 binds|nsubj|END_ENTITY	Phytochrome_B binds with greater apparent affinity than phytochrome A to the basic helix-loop-helix factor PIF3 in a reaction requiring the PAS domain of PIF3 .
19165330	0	PIF3	128,132	phytochrome_B	48,61	PIF3	phytochrome B	837479(Tax:3702)	816394(Tax:3702)	Gene	Gene	signaling|dobj|START_ENTITY binding|advcl|signaling necessary|advcl|binding necessary|nsubj|Residues Residues|acl|clustered clustered|nmod|knot knot|nmod|END_ENTITY	Residues clustered in the light-sensing knot of phytochrome_B are necessary for conformer-specific binding to signaling partner PIF3 .
16278447	0	PIG-P	59,64	Gpi19	0,5	PIG-P	Gpi19	100154885(Tax:9823)	852047(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Gpi19 , the Saccharomyces_cerevisiae homologue of mammalian PIG-P , is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis .
12802054	0	PIG-U	6,11	GPI_transamidase	54,70	PIG-U	GPI transamidase	100154657(Tax:9823)	606750(Tax:9823)	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	Human PIG-U and yeast Cdc91p are the fifth subunit of GPI_transamidase that attaches GPI-anchors to proteins .
15225615	0	PIG11	19,24	P53	2,5	PIG11	P53	9537	7157	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A P53 target gene , PIG11 , contributes to chemosensitivity of cells to arsenic_trioxide .
14695212	0	PIG3	13,17	p53	50,53	PIG3	p53	9540	7157	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors .
23241165	0	PIG3	57,61	p53-inducible_gene_3	35,55	PIG3	p53-inducible gene 3	9540	9540	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Functional repeats -LRB- TGYCC -RRB- n in the p53-inducible_gene_3 -LRB- PIG3 -RRB- promoter and susceptibility to squamous_cell_carcinoma_of_the_head_and_neck .
24388982	0	PIG3	96,100	p53_induced_gene_3	76,94	PIG3	p53 induced gene 3	9540	9540	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Identification of prohibitin and prohibiton as novel factors binding to the p53_induced_gene_3 -LRB- PIG3 -RRB- promoter -LRB- TGYCC -RRB- -LRB- 15 -RRB- motif .
18198489	0	PIGB	66,70	phosphatidylinositol_glycan_Class_B	29,64	PIGB	phosphatidylinositol glycan Class B	9488	9488	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	siRNA-mediated inhibition of phosphatidylinositol_glycan_Class_B -LRB- PIGB -RRB- confers resistance to methylmercury in HEK293 cells .
8575782	0	PIGF	100,104	PIGF	72,76	PIGF	PIGF	5281	5281	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF .
8575782	0	PIGF	72,76	PIGF	100,104	PIGF	PIGF	5281	5281	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF .
8919031	0	PIGF	40,44	placenta_growth_factor	16,38	PIGF	placenta growth factor	5281	5228	Gene	Gene	Localisation|appos|START_ENTITY Localisation|nmod|END_ENTITY	Localisation of placenta_growth_factor -LRB- PIGF -RRB- in human term placenta .
9778119	0	PIGF	32,36	placenta_growth_factor	8,30	PIGF	placenta growth factor	5281	5228	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of placenta_growth_factor -LRB- PIGF -RRB- in human extravillous_trophoblast proliferation , migration and invasiveness .
22824918	0	PIGK	46,50	PIGK	76,80	PIGK	PIGK	10026	10026	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	A single nucleotide polymorphism in the human PIGK gene associates with low PIGK expression in colorectal_cancer patients .
22824918	0	PIGK	76,80	PIGK	46,50	PIGK	PIGK	10026	10026	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	A single nucleotide polymorphism in the human PIGK gene associates with low PIGK expression in colorectal_cancer patients .
21070409	0	PII	0,3	WRINKLED1	18,27	PII	WRINKLED1	828213(Tax:3702)	824599(Tax:3702)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	PII is induced by WRINKLED1 and fine-tunes fatty_acid composition in seeds of Arabidopsis_thaliana .
26373952	0	PIK3CA	52,58	ALK	47,50	PIK3CA	ALK	5290	238	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
19276248	0	PIK3CA	46,52	Androgen_receptor	0,17	PIK3CA	Androgen receptor	5290	367	Gene	Gene	mutations|nummod|START_ENTITY END_ENTITY|nmod|mutations	Androgen_receptor levels and association with PIK3CA mutations and prognosis in breast_cancer .
25153497	0	PIK3CA	61,67	BRAF	69,73	PIK3CA	BRAF	5290	673	Gene	Gene	Genes|appos|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
25627962	0	PIK3CA	11,17	BRAF	41,45	PIK3CA	BRAF	5290	673	Gene	Gene	mutations|compound|START_ENTITY coexist|nsubj|mutations coexist|nmod|mutations mutations|compound|END_ENTITY	Activating PIK3CA mutations coexist with BRAF or NRAS mutations in a limited fraction of melanomas .
25714871	0	PIK3CA	120,126	BRAF	53,57	PIK3CA	BRAF	5290	673	Gene	Gene	Helical|compound|START_ENTITY Comparison|nmod|Helical E17K|dep|Comparison E17K|nmod|Associated Associated|nmod|V600E V600E|compound|END_ENTITY	AKT1 E17K in Colorectal_Carcinoma Is Associated with BRAF V600E but Not MSI-H Status : A Clinicopathologic Comparison to PIK3CA Helical and Kinase Domain Mutants .
26004768	4	PIK3CA	1094,1100	BRAF	1082,1086	PIK3CA	NRAS	5290	4893	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26373952	0	PIK3CA	52,58	BRAF	41,45	PIK3CA	BRAF	5290	673	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
25153497	0	PIK3CA	61,67	EGFR	49,53	PIK3CA	EGFR	5290	1956	Gene	Gene	Genes|appos|START_ENTITY Genes|compound|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
26373952	0	PIK3CA	52,58	EGFR	29,33	PIK3CA	EGFR	5290	1956	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|compound|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
20571907	0	PIK3CA	0,6	KRAS	20,24	PIK3CA	KRAS	5290	3845	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	PIK3CA mutations in KRAS and BRAF wild type colorectal_cancer patients .
22039088	0	PIK3CA	0,6	KRAS	103,107	PIK3CA	KRAS	5290	3845	Gene	Gene	START_ENTITY|acl|exon exon|nmod|antibodies antibodies|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal_cancer : a systematic review and meta-analysis .
22285706	0	PIK3CA	42,48	KRAS	163,167	PIK3CA	KRAS	5290	3845	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene PTEN|dobj|expression PTEN|nmod|therapy therapy|nmod|patients patients|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal_growth_factor_receptor antibody therapy in patients with KRAS wild-type metastatic colorectal_cancer .
22302407	0	PIK3CA	117,123	KRAS	111,115	PIK3CA	KRAS	5290	3845	Gene	Gene	MET|appos|START_ENTITY MET|compound|END_ENTITY	Optimization of patient selection for EGFR-TKIs in advanced non-small_cell_lung_cancer by combined analysis of KRAS , PIK3CA , MET , and non-sensitizing EGFR mutations .
24576621	0	PIK3CA	75,81	KRAS	93,97	PIK3CA	KRAS	18706(Tax:10090)	16653(Tax:10090)	Gene	Gene	wild-type|nummod|START_ENTITY wild-type|appos|colorectal_cancer colorectal_cancer|compound|END_ENTITY	Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type , KRAS mutant colorectal_cancer .
24701207	0	PIK3CA	139,145	KRAS	159,163	PIK3CA	KRAS	5290	3845	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|patients patients|compound|END_ENTITY	Anti-epidermal_growth_factor_receptor monoclonal antibody-based therapy for metastatic colorectal_cancer : a meta-analysis of the effect of PIK3CA mutations in KRAS wild-type patients .
25153497	0	PIK3CA	61,67	KRAS	55,59	PIK3CA	KRAS	5290	3845	Gene	Gene	Genes|appos|START_ENTITY Genes|appos|END_ENTITY	Sensitive Genotyping of Somatic Mutations in the EGFR , KRAS , PIK3CA , BRAF Genes from NSCLC Patients Using Hydrogel Biochips .
26004768	4	PIK3CA	1094,1100	KRAS	1076,1080	PIK3CA	KRAS	5290	3845	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
26019684	0	PIK3CA	0,6	KRAS	117,121	PIK3CA	KRAS	5290	3845	Gene	Gene	Amplification|compound|START_ENTITY Common|nsubj|Amplification Common|nmod|Adenomas Adenomas|nmod|Mutation Mutation|compound|END_ENTITY	PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation .
26019684	0	PIK3CA	0,6	KRAS	117,121	PIK3CA	KRAS	5290	3845	Gene	Gene	Amplification|compound|START_ENTITY Common|nsubj|Amplification Common|nmod|Adenomas Adenomas|nmod|Mutation Mutation|compound|END_ENTITY	PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation .
26373952	0	PIK3CA	52,58	KRAS	35,39	PIK3CA	KRAS	5290	3845	Gene	Gene	PDGFRA|appos|START_ENTITY PDGFRA|appos|END_ENTITY	Molecular genetic studies on EGFR , KRAS , BRAF , ALK , PIK3CA , PDGFRA , and DDR2 in primary pulmonary_adenoid_cystic_carcinoma .
26991109	0	PIK3CA	6,12	KRAS	58,62	PIK3CA	KRAS	5290	3845	Gene	Gene	Alterations|nsubj|START_ENTITY Alterations|nmod|Status Status|compound|END_ENTITY	BRAF , PIK3CA , and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal_Cancers with Distant Metastasis .
21704278	0	PIK3CA	12,18	NRAS	6,10	PIK3CA	NRAS	5290	4893	Gene	Gene	exon|dep|START_ENTITY exon|compound|END_ENTITY	KRAS , NRAS , PIK3CA exon 20 , and BRAF genotypes in synchronous and metachronous primary colorectal_cancers diagnostic and therapeutic implications .
26004768	4	PIK3CA	1094,1100	NRAS	1088,1092	PIK3CA	BRAF	5290	673	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	RESULTS : Only 28 mutations were observed among KRAS , BRAF , NRAS , PIK3CA , EGFR , and PTEN -LRB- in 7.5 % of patients -RRB- , of which the most frequent were in KRAS and PIK3CA .
24908061	0	PIK3CA	36,42	P53	77,80	PIK3CA	P53	5290	7157	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene associated|nsubjpass|polymorphism associated|nmod|expression expression|compound|END_ENTITY	A single nucleotide polymorphism in PIK3CA gene is inversely associated with P53 protein expression in breast_cancer .
26581613	0	PIK3CA	86,92	p110a	54,59	PIK3CA	p110a	5290	5290	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Increased Expression of Phosphatidylinositol 3-Kinase p110a and Gene Amplification of PIK3CA in Nasopharyngeal_Carcinoma .
11959846	0	PIK3CA	42,48	p53	0,3	PIK3CA	p53	5290	7157	Gene	Gene	inhibiting|dobj|START_ENTITY regulates|advcl|inhibiting regulates|nsubj|END_ENTITY	p53 regulates cell survival by inhibiting PIK3CA in squamous_cell_carcinomas .
18270270	0	PIK3CA	40,46	p53	22,25	PIK3CA	p53	5290	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian_cancer .
17475214	0	PIK3IP1	32,39	PI3K	0,4	PIK3IP1	PI3K	113791	5293	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	PI3K is negatively regulated by PIK3IP1 , a novel p110 interacting protein .
23676220	0	PIK3IP1	127,134	PI3K	101,105	PIK3IP1	PI3K	113791	5293	Gene	Gene	reprograms|nmod|START_ENTITY reprograms|dobj|cells cells|nmod|inhibition inhibition|compound|END_ENTITY	Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3K inhibition through PIK3IP1 .
25608840	0	PIK3R3	92,98	MiR-511	0,7	PIK3R3	MiR-511	8503	574445	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-511 inhibits growth and metastasis of human hepatocellular_carcinoma cells by targeting PIK3R3 .
22396535	0	PILRa	64,69	paired_immunoglobulin-like_receptor_a	25,62	PILRa	paired immunoglobulin-like receptor a	29992	29992	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Evolutionarily conserved paired_immunoglobulin-like_receptor_a -LRB- PILRa -RRB- domain mediates its interaction with diverse sialylated ligands .
10660620	0	PILRalpha	0,9	SHP-1	92,97	PILRalpha	SHP-1	29992	5777	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	PILRalpha , a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein , recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta .
11581162	0	PIM	77,80	separase	11,19	PIM	separase	34404(Tax:7227)	38640(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Drosophila separase is required for sister chromatid separation and binds to PIM and THR .
12125076	0	PIMT	66,70	protein-L-isoaspartyl_methyltransferase	25,64	PIMT	protein-L-isoaspartyl methyltransferase	18537(Tax:10090)	18537(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Adenoviral expression of protein-L-isoaspartyl_methyltransferase -LRB- PIMT -RRB- partially attenuates the biochemical changes in PIMT-deficient mice .
19595712	0	PIN1	92,96	FAK	76,79	PIN1	FAK	23988(Tax:10090)	14083(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST .
26964091	0	PIN1	38,42	Hypoxia-Inducible_Factor-1a	76,103	PIN1	Hypoxia-Inducible Factor-1a	5300	3091	Gene	Gene	Binds|compound|START_ENTITY Binds|nmod|END_ENTITY	Correction : Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible_Factor-1a .
16245157	0	PIN2	101,105	proteinase_inhibitor	79,99	PIN2	proteinase inhibitor	102581269	102581269	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assessment of nematode resistance in wheat transgenic plants expressing potato proteinase_inhibitor -LRB- PIN2 -RRB- gene .
15596544	0	PINCH	22,27	JNK	38,41	PINCH	JNK	40999(Tax:7227)	44801(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras_suppressor_1 .
15596544	0	PINCH	22,27	Ras_suppressor_1	92,108	PINCH	Ras suppressor 1	40999(Tax:7227)	34774(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras_suppressor_1 .
24058607	0	PINCH	8,13	Rsu-1	47,52	PINCH	Rsu-1	110829(Tax:10090)	20163(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis .
20689998	0	PINCH	9,14	TNF-a	31,36	PINCH	TNF-a	3987	7124	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Neuronal PINCH is regulated by TNF-a and is required for neurite extension .
10022929	0	PINCH	21,26	integrin-linked_kinase	51,73	PINCH	integrin-linked kinase	3987	3611	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The LIM-only protein PINCH directly interacts with integrin-linked_kinase and is recruited to integrin-rich sites in spreading cells .
11078733	0	PINCH	49,54	integrin-linked_kinase	116,138	PINCH	integrin-linked kinase	3987	3611	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked_kinase ankyrin repeat domain .
19117955	0	PINCH	68,73	integrin-linked_kinase	77,99	PINCH	integrin-linked kinase	3987	3611	Gene	Gene	adaptor|dobj|START_ENTITY adaptor|nmod|END_ENTITY	Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked_kinase .
25647720	0	PINCH-1	73,80	Ras_suppressor-1	0,16	PINCH-1	Ras suppressor-1	3987	6251	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Ras_suppressor-1 promotes apoptosis in breast_cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis -LRB- PUMA -RRB- ; verification from metastatic breast_cancer human samples .
20530873	0	PINCH1	0,6	Akt1	17,21	PINCH1	Akt1	3987	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha .
24383081	0	PINK1	28,33	BAG2	4,8	PINK1	BAG2	65018	9532	Gene	Gene	stabilises|dobj|START_ENTITY stabilises|nsubj|protein protein|compound|END_ENTITY	The BAG2 protein stabilises PINK1 by decreasing its ubiquitination .
24513209	0	PINK1	28,33	BAG2	4,8	PINK1	BAG2	65018	9532	Gene	Gene	START_ENTITY|nsubj|Stabilises Stabilises|compound|END_ENTITY	The BAG2 Protein Stabilises PINK1 By Decreasing its Ubiquitination .
20057503	0	PINK1	33,38	Beclin1	54,61	PINK1	Beclin1	65018	8678	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy .
23772688	0	PINK1	40,45	Drp1	150,154	PINK1	Drp1	65018	10059	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	The Parkinson 's _ disease-associated gene PINK1 protects neurons from ischemic_damage by decreasing mitochondrial translocation of the fission promoter Drp1 .
25305081	0	PINK1	0,5	HDAC3	27,32	PINK1	HDAC3	65018	8841	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death .
17906618	0	PINK1	87,92	HtrA2	27,32	PINK1	HtrA2	65018	27429	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The mitochondrial protease HtrA2 is regulated by Parkinson 's _ disease-associated kinase PINK1 .
26379191	0	PINK1	48,53	Inhibitory_PAS_domain_protein	0,29	PINK1	Inhibitory PAS domain protein	65018	64344	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Inhibitory_PAS_domain_protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson 's _ disease model .
20153330	0	PINK1	0,5	LC3	67,70	PINK1	LC3	65018	84557	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy .
26555609	0	PINK1	15,20	NRF2	0,4	PINK1	NRF2	65018	4780	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions .
21138942	0	PINK1	0,5	PARL	62,66	PINK1	PARL	65018	55486	Gene	Gene	cleavage|nsubj|START_ENTITY cleavage|nmod|END_ENTITY	PINK1 cleavage at position A103 by the mitochondrial protease PARL .
23303188	0	PINK1	20,25	PTEN-induced_putative_kinase_1	27,57	PINK1	PTEN-induced putative kinase 1	65018	65018	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Characterization of PINK1 -LRB- PTEN-induced_putative_kinase_1 -RRB- mutations associated with Parkinson_disease in mammalian cells and Drosophila .
19358826	0	PINK1	18,23	Parkin	0,6	PINK1	Parkin	65018	5071	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Parkin stabilizes PINK1 through direct interaction .
20194754	0	PINK1	27,32	parkin	11,17	PINK1	parkin	31607(Tax:7227)	40336(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin .
16601102	0	PINOID	34,40	PDK1	125,129	PINOID	PDK1	818030(Tax:3702)	830330(Tax:3702)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation and activation of PINOID by the phospholipid_signaling_kinase_3-phosphoinositide-dependent_protein_kinase_1 -LRB- PDK1 -RRB- in Arabidopsis .
12890565	0	PIP	57,60	GCDFP-15	48,56	PIP	GCDFP-15	5304	5304	Gene	Gene	gene|compound|START_ENTITY Expression|dep|gene Expression|nmod|END_ENTITY	Expression of the mouse homologue for the human GCDFP-15 / PIP gene during pre - and early post-natal development .
24416635	0	PIP	77,80	Gross_Cystic_Disease_Fluid_Protein-15	0,37	PIP	Gross Cystic Disease Fluid Protein-15	5304	5304	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Gross_Cystic_Disease_Fluid_Protein-15 -LRB- GCDFP-15 -RRB- / Prolactin-Inducible_Protein -LRB- PIP -RRB- as Functional Salivary Biomarker for Primary Sj gren 's Syndrome .
22119528	0	PIP	14,17	WNK1	0,4	PIP	WNK1	5304	65125	Gene	Gene	synthesis|compound|START_ENTITY promotes|dobj|synthesis promotes|nsubj|END_ENTITY	WNK1 promotes PIP synthesis to coordinate growth factor and GPCR-Gq signaling .
10576657	0	PIP	52,55	prolactin-inducible_protein	23,50	PIP	prolactin-inducible protein	5304	5304	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The potential role for prolactin-inducible_protein -LRB- PIP -RRB- as a marker of human breast_cancer micrometastasis .
20052012	0	PIP	76,79	prolactin-inducible_protein	47,74	PIP	prolactin-inducible protein	18716(Tax:10090)	18716(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Generation and initial characterization of the prolactin-inducible_protein -LRB- PIP -RRB- null mouse : accompanying global changes in gene expression in the submandibular gland .
12748191	0	PIP2	25,29	Adr1p	106,111	PIP2	Adr1p	854545(Tax:4932)	851802(Tax:4932)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Saccharomyces_cerevisiae PIP2 mediating oleic_acid induction and peroxisome proliferation is regulated by Adr1p and Pip2p-Oaf1p .
20945365	0	PIP5K	14,19	Arf6	32,36	PIP5K	Arf6	79837	382	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of PIP5K activity by Arf6 and its physiological significance .
16914734	0	PIRH2	6,11	androgen_receptor	21,38	PIRH2	androgen receptor	25898	367	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Human PIRH2 enhances androgen_receptor signaling through inhibition of histone_deacetylase_1 and is overexpressed in prostate_cancer .
15951434	0	PIST	77,81	golgin-160	32,42	PIST	golgin-160	57120	2802	Gene	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST .
7721104	0	PIT-1	94,99	GHF-1	88,93	PIT-1	GHF-1	5449	5449	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A novel pituitary transcription factor is produced by alternative splicing of the human GHF-1 / PIT-1 gene .
8666747	0	PIT-1	55,60	GHF-1	49,54	PIT-1	GHF-1	25517(Tax:10116)	25517(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of the pituitary transcription factor GHF-1 / PIT-1 in cell types of the adult porcine adenohypophysis .
25822178	0	PIT-1	28,33	POU1F1	35,41	PIT-1	POU1F1	5449	5449	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Dose-Dependent Dual Role of PIT-1 -LRB- POU1F1 -RRB- in Somatolactotroph Cell Proliferation and Apoptosis .
23380306	0	PIT-1	56,61	growth_hormone	152,166	PIT-1	growth hormone	5449	2688	Gene	Gene	mutation|compound|START_ENTITY adolescent|nmod|mutation profiling|nmod|adolescent profiling|dep|insights insights|nmod|effects effects|nmod|END_ENTITY	Urine metabonomic profiling of a female adolescent with PIT-1 mutation before and during growth_hormone therapy : insights into the metabolic effects of growth_hormone .
8098921	0	PIT-1	82,87	growth_hormone	108,122	PIT-1	growth hormone	397325(Tax:9823)	81668(Tax:10116)	Gene	Gene	START_ENTITY|appos|gene gene|acl|controlling controlling|dobj|expression expression|amod|END_ENTITY	Cloning and restriction fragment length polymorphism analysis of a cDNA for swine PIT-1 , a gene controlling growth_hormone expression .
7702212	0	PIT1	109,113	PIT1	81,85	PIT1	PIT1	282315(Tax:9913)	282315(Tax:9913)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Restriction fragment length polymorphism in amplification products of the bovine PIT1 gene and assignment of PIT1 to bovine chromosome 1 .
7702212	0	PIT1	81,85	PIT1	109,113	PIT1	PIT1	282315(Tax:9913)	282315(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Restriction fragment length polymorphism in amplification products of the bovine PIT1 gene and assignment of PIT1 to bovine chromosome 1 .
9258347	0	PITALRE	20,27	pRb	43,46	PITALRE	pRb	1025	5925	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	CDC2-related_kinase PITALRE phosphorylates pRb exclusively on serine and is widely expressed in human tissues .
17023142	0	PITK	35,39	CaMKII	43,49	PITK	CaMKII	23243	818	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dual kinase-mediated regulation of PITK by CaMKII and GSK3 .
26977884	0	PITPNC1	0,7	RAB1B	17,22	PITPNC1	RAB1B	26207	81876	Gene	Gene	Recruits|compound|START_ENTITY END_ENTITY|nsubj|Recruits	PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion .
21300782	0	PITX1	18,23	TERT	29,33	PITX1	TERT	5307	7015	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of PITX1 as a TERT suppressor gene located on human chromosome 5 .
24002705	0	PITX2	41,46	Cyclin_A1	0,9	PITX2	Cyclin A1	5308	8900	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cyclin_A1 is a transcriptional target of PITX2 and overexpressed in papillary_thyroid_carcinoma .
11763998	0	PITX2	46,51	Dlx2	27,31	PITX2	Dlx2	5308	1746	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Antagonistic regulation of Dlx2 expression by PITX2 and Msx2 : implications for tooth development .
22919265	0	PITX2	99,104	EFEMP2	81,87	PITX2	EFEMP2	5308	30008	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Yeast two-hybrid analysis of a human trabecular meshwork cDNA library identified EFEMP2 as a novel PITX2 interacting protein .
21873665	0	PITX2	0,5	SLC13A3	103,110	PITX2	SLC13A3	5308	64849	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3 .
22495974	0	PITX2	39,44	androgen_receptor	77,94	PITX2	androgen receptor	5308	367	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Global methylation analysis identifies PITX2 as an upstream regulator of the androgen_receptor and IGF-I_receptor genes in prostate_cancer .
12692125	0	PITX2	0,5	atrial_natriuretic_factor	37,62	PITX2	atrial natriuretic factor	18741(Tax:10090)	230899(Tax:10090)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	PITX2 isoform-specific regulation of atrial_natriuretic_factor expression : synergism and repression with Nkx2 .5 .
15466416	0	PITX2	70,75	atrial_natriuretic_factor	32,57	PITX2	atrial natriuretic factor	5308	4878	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Cell-specific activation of the atrial_natriuretic_factor promoter by PITX2 and MEF2A .
20084168	0	PITX3	103,108	paired-like_homeodomain_3	76,101	PITX3	paired-like homeodomain 3	100422803	100422803	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like_homeodomain_3 -LRB- PITX3 -RRB- gene .
25193865	0	PIWIL2	0,6	c-Myc	15,20	PIWIL2	c-Myc	55124	4609	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation .
11593385	0	PI_3-K	114,120	Akt	121,124	PI 3-K	Akt	5293	207	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The anti-apoptotic role of interleukin-6 in human cervical_cancer is mediated by up-regulation of Mcl-1 through a PI_3-K / Akt pathway .
14755253	0	PI_3-K	58,64	Akt	65,68	PI 3-K	Akt	5293	207	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Inositol_pentakisphosphate promotes apoptosis through the PI_3-K / Akt pathway .
23563366	0	PI_3-K	54,60	Akt	62,65	PI 3-K	Akt	5293	207	Gene	Gene	mTOR|compound|START_ENTITY mTOR|appos|END_ENTITY	Therapeutic targets for cancer : current concepts with PI_3-K , Akt , _ mTOR .
22388478	0	PI_3-K	89,95	mTOR	96,100	PI 3-K	mTOR	5293	21977(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Prevention of b-amyloid degeneration of microglia by erythropoietin depends on Wnt1 , the PI_3-K / mTOR pathway , Bad , and Bcl-xL .
11179472	0	PI_3-kinase	34,45	AKT	46,49	PI 3-kinase	AKT	5293	207	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Ultraviolet irradiation activates PI_3-kinase / AKT survival pathway via EGF receptors in human skin in vivo .
25792980	0	PI_3_K	76,82	mTOR	83,87	PI 3 K	mTOR	5293	21977(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Insulin Increases Sestrin_2 Content by Reducing Its Degradation through the PI_3_K / mTOR Signaling Pathway .
9028319	0	PI_3_kinase	125,136	Thrombopoietin	0,14	PI 3 kinase	Thrombopoietin	5295	7066	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Thrombopoietin enhances the alpha IIb beta_3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI_3_kinase .
24228869	0	PK-C	105,109	PLC	91,94	PK-C	PLC	43428(Tax:7227)	32601(Tax:7227)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Vitellogenesis in the fruit_fly , Drosophila_melanogaster : antagonists demonstrate that the PLC , IP3/DAG , PK-C pathway is triggered by calmodulin .
12757721	1	PK-C	92,96	protein_kinase_C	74,90	PK-C	protein kinase C	112476	112476	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect on protein_kinase_C -LRB- PK-C -RRB- binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones .
10762718	0	PKA	73,76	S100beta	0,8	PKA	S100beta	25636(Tax:10116)	25742(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	S100beta inhibits the phosphorylation of the L-MAG cytoplasmic domain by PKA .
22659114	0	PKA	67,70	YC-1	0,4	PKA	YC-1	25636(Tax:10116)	24421(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	YC-1 , a potent antithrombotic agent , induces lipolysis through the PKA pathway in rat visceral fat cells .
25185555	0	PKA	0,3	cardiac_troponin_I	23,41	PKA	cardiac troponin I	25636(Tax:10116)	29248(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	PKA phosphorylation of cardiac_troponin_I modulates activation and relaxation kinetics of ventricular myofibrils .
15956780	0	PKA	82,85	glucose-6-phosphate_dehydrogenase	30,63	PKA	glucose-6-phosphate dehydrogenase	25636(Tax:10116)	24377(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Diabetes causes inhibition of glucose-6-phosphate_dehydrogenase via activation of PKA , which contributes to oxidative stress in rat kidney cortex .
11907174	0	PKA	91,94	protein_kinase_A	73,89	PKA	protein kinase A	25636(Tax:10116)	25636(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Differential effects of haloperidol and clozapine on -LSB- -LRB- 3 -RRB- H -RSB- cAMP binding , protein_kinase_A -LRB- PKA -RRB- activity , and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain .
11432986	0	PKB	63,66	caspase_3	17,26	PKB	caspase 3	207	836	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Lithium inhibits caspase_3 activation and dephosphorylation of PKB and GSK3 induced by K + deprivation in cerebellar granule cells .
11781306	0	PKB	85,88	protein_kinase_B	67,83	PKB	protein kinase B	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Phosphatidylinositol -LRB- 3,4,5 -RRB- P3 is essential but not sufficient for protein_kinase_B -LRB- PKB -RRB- activation ; phosphatidylinositol -LRB- 3,4 -RRB- P2 is required for PKB phosphorylation at Ser-473 : studies using cells from SH2-containing_inositol-5-phosphatase knockout mice .
16902245	0	PKB/AKT	65,72	protein_kinase_B	47,63	PKB/AKT	protein kinase B	207	2185	Gene	Gene	Identification|appos|START_ENTITY Identification|nmod|inhibitors inhibitors|nmod|END_ENTITY	Identification of small-molecule inhibitors of protein_kinase_B -LRB- PKB/AKT -RRB- in an AlphaScreenTM high-throughput screen .
9857186	0	PKBalpha	61,69	protein_kinase_Balpha	38,59	PKBalpha	protein kinase Balpha	207	207	Gene	Gene	Inactivation|appos|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation and dephosphorylation of protein_kinase_Balpha -LRB- PKBalpha -RRB- promoted by hyperosmotic stress .
23108398	0	PKC	0,3	BAG3	34,38	PKC	BAG3	100774348	100758034	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	PKC - mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid_cancer FRO cells .
10419648	0	PKC	21,24	CD27	0,4	PKC	CD27	112476	939	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	CD27 signals through PKC in human B_cell_lymphomas .
20476579	0	PKC	9,12	CD73	30,34	PKC	CD73	112476	4907	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	-LSB- Role of PKC in regulation of CD73 by lysophosphatidylcholine in human endothelial cells -RSB- .
18413231	0	PKC	35,38	ERK	0,3	PKC	ERK	112476	5594	Gene	Gene	role|nmod|START_ENTITY role|nsubj|activation activation|compound|END_ENTITY	ERK activation is only one role of PKC in TCR-independent cytotoxic T cell granule exocytosis .
21079811	0	PKC	115,118	ERK	121,124	PKC	ERK	112476	5594	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	ER-a36 , a novel variant of ER-a , mediates estrogen-stimulated proliferation of endometrial_carcinoma cells via the PKC / ERK pathway .
21362509	0	PKC	47,50	Evi-1	18,23	PKC	Evi-1	5580	2122	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Evi-1 as a novel effector of PKC in the apoptotic response to DNA damage .
16474935	0	PKC	8,11	Fos	29,32	PKC	Fos	112476	2353	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of PKC in regulation of Fos and TH expression after naloxone induced morphine withdrawal in the heart .
24788043	0	PKC	25,28	NHE3	0,4	PKC	NHE3	112476	6550	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	NHE3 phosphorylation via PKC marks the polarity and orientation of directionally migrating cells .
25742010	0	PKC	0,3	PDK1	36,40	PKC	PDK1	112476	5163	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	PKC / Rdx-driven Phosphorylation of PDK1 : A Novel Mechanism Promoting Cancer Cell Survival and Permissiveness for Parvovirus-induced Lysis .
25524223	0	PKC	16,19	PDLIM5	0,6	PKC	PDLIM5	5581	10611	Gene	Gene	translocation|compound|START_ENTITY mediates|dobj|translocation mediates|nsubj|END_ENTITY	PDLIM5 mediates PKC translocation in PMA-induced growth cone collapse .
20512658	0	PKC	26,29	PKC_delta	15,24	PKC	PKC delta	5580	5580	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of PKC_delta -LRB- PKC -RRB- in the resistance against different doxorubicin analogs .
25000588	0	PKC	67,70	Protein_Kinase_C	47,63	PKC	Protein Kinase C	112476	112476	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Discovery of Selective and Orally Bioavailable Protein_Kinase_C -LRB- PKC -RRB- Inhibitors from a Fragment Hit .
27094369	0	PKC	0,3	STAT3	21,26	PKC	STAT3	24681(Tax:10116)	25125(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PKC interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy .
24825907	0	PKC	60,63	protein_kinase_C	40,56	PKC	protein kinase C	112476	112476	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of oncogenic protein_kinase_C -LRB- PKC -RRB- by STAT1 and Sp1 proteins .
8562306	0	PKC	34,37	protein_kinase_C	16,32	PKC	protein kinase C	24681(Tax:10116)	24681(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	The heat-stable protein_kinase_C -LRB- PKC -RRB- stimulatory factor in the rat ovary may allow PKC to be active independent of cell membrane lipids .
21645497	0	PKC	61,64	protein_kinase_C-zeta	38,59	PKC	protein kinase C-zeta	5590	5590	Gene	Gene	dephosphorylation|appos|START_ENTITY dephosphorylation|nmod|END_ENTITY	Differential dephosphorylation of the protein_kinase_C-zeta -LRB- PKC -RRB- in an integrin aIIbb3-dependent manner in platelets .
20122916	0	PKC-3	11,16	PAR-3	29,34	PKC-3	PAR-3	173914(Tax:6239)	175783(Tax:6239)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding to PKC-3 , but not to PAR-3 or to a conventional PDZ domain ligand , is required for PAR-6 function in C. _ elegans .
25391900	0	PKC-a	0,5	ERK1/2	87,93	PKC-a	ERK1/2	5578	5595;5594	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	PKC-a contributes to high NaCl-induced activation of NFAT5 -LRB- TonEBP/OREBP -RRB- through MAPK ERK1/2 .
14709334	0	PKC-alpha	20,29	JNK	67,70	PKC-alpha	JNK	5578	5599	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|END_ENTITY	Cooperation between PKC-alpha and PKC-epsilon in the regulation of JNK activation in human lung_cancer cells .
9548940	0	PKC-alpha	78,87	PKC-delta	101,110	PKC-alpha	PKC-delta	18750(Tax:10090)	18753(Tax:10090)	Gene	Gene	elevates|nsubj|START_ENTITY elevates|dobj|level level|amod|END_ENTITY	Cross-talk between protein_kinase_C-alpha -LRB- PKC-alpha -RRB- _ and _ - delta -LRB- PKC-delta -RRB- : PKC-alpha elevates the PKC-delta protein level , altering its mRNA transcription and degradation .
18239055	0	PKC-alpha	79,88	PTEN	18,22	PKC-alpha	PTEN	5578	5728	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic_cancer cells .
15930143	0	PKC-alpha	52,61	RhoA	22,26	PKC-alpha	RhoA	5578	387	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of RhoA with specific domains of PKC-alpha .
18323518	0	PKC-alpha	45,54	VEGF	27,31	PKC-alpha	VEGF	282001(Tax:9913)	281572(Tax:9913)	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells .
11290387	0	PKC-alpha	118,127	protein_kinase_C-alpha	94,116	PKC-alpha	protein kinase C-alpha	5578	5578	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Effects of apolipoprotein_E _ -LRB- apoE -RRB- _ isoforms , _ beta-amyloid _ -LRB- Abeta -RRB- and apoE/Abeta complexes on protein_kinase_C-alpha -LRB- PKC-alpha -RRB- translocation and amyloid_precursor_protein -LRB- APP -RRB- processing in human SH-SY5Y neuroblastoma cells and fibroblasts .
14687784	0	PKC-alpha	36,45	protein_kinase_C-alpha	12,34	PKC-alpha	protein kinase C-alpha	5578	5578	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of protein_kinase_C-alpha -LRB- PKC-alpha -RRB- in malignancies of the gastrointestinal tract .
15057036	0	PKC-alpha	36,45	protein_kinase_C-alpha	12,34	PKC-alpha	protein kinase C-alpha	5578	5578	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of protein_kinase_C-alpha -LRB- PKC-alpha -RRB- in melanoma .
15180529	0	PKC-alpha	36,45	protein_kinase_C-alpha	12,34	PKC-alpha	protein kinase C-alpha	5578	5578	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of protein_kinase_C-alpha -LRB- PKC-alpha -RRB- in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen .
24136171	0	PKC-b	8,13	CD86	43,47	PKC-b	CD86	5579	942	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of PKC-b in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells .
17313671	0	PKC-beta	49,57	protein_kinase_C-beta	26,47	PKC-beta	protein kinase C-beta	5579	5579	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Retrospective analysis of protein_kinase_C-beta -LRB- PKC-beta -RRB- expression in lymphoid_malignancies and its association with survival in diffuse large B-cell_lymphomas .
9548940	0	PKC-delta	101,110	PKC-alpha	78,87	PKC-delta	PKC-alpha	18753(Tax:10090)	18750(Tax:10090)	Gene	Gene	level|amod|START_ENTITY elevates|dobj|level elevates|nsubj|END_ENTITY	Cross-talk between protein_kinase_C-alpha -LRB- PKC-alpha -RRB- _ and _ - delta -LRB- PKC-delta -RRB- : PKC-alpha elevates the PKC-delta protein level , altering its mRNA transcription and degradation .
16325485	0	PKC-delta	30,39	Parathyroid_hormone	0,19	PKC-delta	Parathyroid hormone	18753(Tax:10090)	19226(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Parathyroid_hormone activates PKC-delta and regulates osteoblastic differentiation via a PLC-independent pathway .
15850832	0	PKC-delta	32,41	protein_kinase_C-delta	8,30	PKC-delta	protein kinase C-delta	5580	5580	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of protein_kinase_C-delta -LRB- PKC-delta -RRB- in the generation of the effects of IFN-alpha in chronic_myelogenous_leukemia cells .
17407153	0	PKC-delta	117,126	protein_kinase_C-delta	93,115	PKC-delta	protein kinase C-delta	5580	5580	Gene	Gene	signal|appos|START_ENTITY signal|amod|END_ENTITY	Expression of cyclin_D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein_kinase_C-delta -LRB- PKC-delta -RRB- signal pathway .
14749212	0	PKC-delta_and_CaMKII-delta_2	0,28	ERK1/2	65,71	PKC-delta and CaMKII-delta 2	ERK1/2	5580	5595;5594	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|END_ENTITY	PKC-delta_and_CaMKII-delta_2 mediate ATP-dependent activation of ERK1/2 in vascular smooth muscle .
11909643	0	PKC-delta_and_ERK	87,104	NKCC1	14,19	PKC-delta and ERK	NKCC1	5580;5594	6558	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|Activation Activation|nmod|END_ENTITY	Activation of NKCC1 by hyperosmotic stress in human tracheal epithelial cells involves PKC-delta_and_ERK .
9395450	0	PKC-epsilon	0,11	ERK1/2	60,66	PKC-epsilon	ERK1/2	5581	5595;5594	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells .
11702063	0	PKC-gamma	0,9	connexin_46	29,40	PKC-gamma	connexin 46	24681(Tax:10116)	79217(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	PKC-gamma phosphorylation of connexin_46 in the lens cortex .
18796635	0	PKC-theta	0,9	Rap1	65,69	PKC-theta	Rap1	5588	5906	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	PKC-theta selectively controls the adhesion-stimulating molecule Rap1 .
12942541	0	PKC-zeta	0,8	ERK	62,65	PKC-zeta	ERK	5590	5594	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	PKC-zeta is required for angiotensin_II-induced activation of ERK and synthesis of C-FOS in MCF-7 cells .
8797581	0	PKC-zeta	41,49	protein_kinase_C-zeta	18,39	PKC-zeta	protein kinase C-zeta	25522(Tax:10116)	25522(Tax:10116)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of protein_kinase_C-zeta -LRB- PKC-zeta -RRB- inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells .
12185498	0	PKC1	24,28	BCK2	79,83	PKC1	BCK2	852169(Tax:4932)	856914(Tax:4932)	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	KNR4 is a member of the PKC1 signalling pathway and genetically interacts with BCK2 , a gene involved in cell cycle progression in Saccharomyces_cerevisiae .
17126529	0	PKCI-1	58,64	RGSZ1	0,5	PKCI-1	RGSZ1	3094	8601	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	RGSZ1 interacts with protein_kinase_C_interacting_protein PKCI-1 and modulates mu opioid receptor signaling .
22390153	0	PKCZ	22,26	insulin	83,90	PKCZ	insulin	5590	3630	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Protein expression of PKCZ -LRB- Protein_Kinase_C_Zeta -RRB- , Munc18c , and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic_ovary_syndrome -LRB- PCOS -RRB- .
11052626	0	PKC_alpha	92,101	ATPase	41,47	PKC alpha	ATPase	5578	1769	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Selective modulation of P-glycoprotein 's ATPase and anion efflux regulation activities with PKC_alpha and PKC_epsilon in Sf9 cells .
18456255	0	PKC_alpha	92,101	ERK	102,105	PKC alpha	ERK	5578	5594	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interferon-alpha enhances artemisinin-induced differentiation_of_HL-60_leukemia cells via a PKC_alpha / ERK pathway .
19097143	0	PKC_alpha	88,97	IL-1_beta	0,9	PKC alpha	IL-1 beta	5578	3553	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	IL-1_beta induces urokinase-plasminogen activator expression and cell migration through PKC_alpha , JNK1/2 , and NF-kappaB in A549 cells .
12693944	0	PKC_alpha	56,65	IL-6	25,29	PKC alpha	IL-6	5578	3569	Gene	Gene	activation|compound|START_ENTITY mediated|nmod|activation mediated|nsubjpass|expression expression|compound|END_ENTITY	Arachidonic_acid-induced IL-6 expression is mediated by PKC_alpha activation in osteoblastic cells .
7589454	0	PKC_alpha	0,9	PDGF-B	37,43	PKC alpha	PDGF-B	5578	5155	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PKC_alpha regulates thrombin-induced PDGF-B chain gene expression in mesangial cells .
19356803	0	PKC_alpha	26,35	PKC_theta	0,9	PKC alpha	PKC theta	18750(Tax:10090)	18761(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	PKC_theta cooperates with PKC_alpha in alloimmune responses of T cells in vivo .
16740968	0	PKC_alpha	171,180	protein_kinase_C_alpha	15,37	PKC alpha	protein kinase C alpha	18750(Tax:10090)	18750(Tax:10090)	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of protein_kinase_C_alpha -LRB- PKC_alpha -RRB- in the early action of angiotensin II type 2 -LRB- AT2 -RRB- effects on neurite outgrowth in NG108-15 cells : AT2-receptor inhibits PKC_alpha and p21ras activity .
11779150	0	PKC_and_ERK	41,52	VEGF	21,25	PKC and ERK	VEGF	26413(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	High glucose induced VEGF expression via PKC_and_ERK in glomerular podocytes .
12842914	0	PKC_delta	0,9	Dishevelled	27,38	PKC delta	Dishevelled	404226(Tax:8355)	399301(Tax:8355)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|function function|compound|END_ENTITY	PKC_delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements .
14527959	0	PKC_delta	56,65	NF-kappa_B	66,76	PKC delta	NF-kappa B	5580	4790	Gene	Gene	Induction|nmod|START_ENTITY Induction|parataxis|END_ENTITY	Induction of cIAP-2 in human colon_cancer cells through PKC_delta / NF-kappa_B .
20512658	0	PKC_delta	15,24	PKC	26,29	PKC delta	PKC	5580	5580	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of PKC_delta -LRB- PKC -RRB- in the resistance against different doxorubicin analogs .
17689924	0	PKC_delta	142,151	c-Met	82,87	PKC delta	c-Met	5580	4233	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|dep|signaling	Lysophosphatidic_acid modulates c-Met redistribution and hepatocyte_growth_factor / c-Met signaling in human bronchial epithelial cells through PKC_delta and E-cadherin .
14527959	0	PKC_delta	56,65	cIAP-2	13,19	PKC delta	cIAP-2	5580	330	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cIAP-2 in human colon_cancer cells through PKC_delta / NF-kappa_B .
10854711	0	PKC_delta	14,23	placental_lactogen-1	55,75	PKC delta	placental lactogen-1	5580	53950(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of PKC_delta expression by estrogen and rat placental_lactogen-1 in luteinized rat ovarian granulosa cells .
17959229	0	PKC_delta	36,45	protein_kinase_C_delta	12,34	PKC delta	protein kinase C delta	5580	5580	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Analysis of protein_kinase_C_delta -LRB- PKC_delta -RRB- expression in endometrial_tumors .
12581866	0	PKC_epsilon	0,11	ERK1/2	22,28	PKC epsilon	ERK1/2	18754(Tax:10090)	26417;26413	Gene	Gene	START_ENTITY|dep|activation activation|compound|END_ENTITY	PKC_epsilon - mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cells .
18534741	0	PKC_epsilon	14,25	ERK1/2	67,73	PKC epsilon	ERK1/2	5581	5595;5594	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|nmod|END_ENTITY	Activation of PKC_epsilon induces lactotroph proliferation through ERK1/2 in response to phorbol_ester .
16584980	0	PKC_epsilon	77,88	TNF-related_apoptosis-inducing_ligand	0,37	PKC epsilon	TNF-related apoptosis-inducing ligand	5581	8743	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- and erythropoiesis : a role for PKC_epsilon .
18577575	0	PKC_gamma	0,9	spinocerebellar_ataxia_type_14	23,53	PKC gamma	spinocerebellar ataxia type 14	5582	5582	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	PKC_gamma mutations in spinocerebellar_ataxia_type_14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling .
12697420	0	PKC_gamma_and_gap	20,37	LEDGF	0,5	PKC gamma and gap	LEDGF	5582	11168	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	LEDGF activation of PKC_gamma_and_gap junction disassembly in lens epithelial cells .
19356803	0	PKC_theta	0,9	PKC_alpha	26,35	PKC theta	PKC alpha	18761(Tax:10090)	18750(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	PKC_theta cooperates with PKC_alpha in alloimmune responses of T cells in vivo .
18353303	0	PKC_zeta	67,75	GSK3_beta	0,9	PKC zeta	GSK3 beta	5590	2932	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	GSK3_beta mediates acentromeric spindle stabilization by activated PKC_zeta .
22536444	0	PKCa	0,4	G3BP2	11,16	PKCa	G3BP2	5578	9908	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	PKCa binds G3BP2 and regulates stress granule formation following cellular stress .
23776598	0	PKCa	52,56	RhoGDI	25,31	PKCa	RhoGDI	5578	396	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cholecystokinin-mediated RhoGDI phosphorylation via PKCa promotes both RhoA and Rac1 signaling .
22469974	0	PKCa	0,4	RhoGDI2	24,31	PKCa	RhoGDI2	5578	397	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	PKCa phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity .
23882690	0	PKCa	8,12	Src	27,30	PKCa	Src	24680(Tax:10116)	83805(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY Role|nmod|activation Role|nmod|END_ENTITY	Role of PKCa activation of Src , PI-3K / AKT , and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells .
21658388	0	PKCa	90,94	WT1	57,60	PKCa	WT1	5578	7490	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Inhibitory mechanism of pure curcumin on Wilms ' _ tumor_1 -LRB- WT1 -RRB- gene expression through the PKCa signaling pathway in leukemic K562 cells .
23609277	0	PKCa	98,102	adenosine_A1_receptor	121,142	PKCa	adenosine A1 receptor	24680(Tax:10116)	29290(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Hemorrhagic preconditioning improves vascular reactivity after hemorrhagic_shock by activation of PKCa and PKC via the adenosine_A1_receptor in rats .
24040137	0	PKCa	84,88	miR-203	0,7	PKCa	miR-203	5578	406986	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-203 inhibits cell proliferation and migration_of_lung_cancer cells by targeting PKCa .
26323260	0	PKCa	121,125	protein_kinase_Ca	102,119	PKCa	protein kinase Ca	5578	5578	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Reversal of efflux of an anticancer drug in human drug-resistant breast cancer cells by inhibition of protein_kinase_Ca -LRB- PKCa -RRB- activity .
26323260	0	PKCa	121,125	protein_kinase_Ca	102,119	PKCa	protein kinase Ca	5578	5578	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Reversal of efflux of an anticancer drug in human drug-resistant breast cancer cells by inhibition of protein_kinase_Ca -LRB- PKCa -RRB- activity .
17109817	0	PKCalpha	15,23	PKCdelta	43,51	PKCalpha	PKCdelta	5578	5580	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Involvement of PKCalpha in insulin-induced PKCdelta expression : Importance of SP-1_and_NFkappaB transcription factors .
18503554	0	PKCalpha	59,67	TRPV1	45,50	PKCalpha	TRPV1	5578	7442	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Heat-induced MMP-1 expression is mediated by TRPV1 through PKCalpha signaling in HaCaT cells .
16963226	0	PKCalpha	0,8	cPLA2	61,66	PKCalpha	cPLA2	5578	5321	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	PKCalpha regulates phosphorylation and enzymatic activity of cPLA2 in vitro and in activated human monocytes .
15505044	0	PKCalpha	50,58	lacrimal_gland_protein	66,88	PKCalpha	lacrimal gland protein	24680(Tax:10116)	292801(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of overexpression of constitutively active PKCalpha on rat lacrimal_gland_protein secretion .
19669929	0	PKCdelta	114,122	CCL15	14,19	PKCdelta	CCL15	5580	6359	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Leukotactin-1 / CCL15 induces cell migration and differentiation of human eosinophilic_leukemia EoL-1 cells through PKCdelta activation .
17346795	0	PKCdelta	8,16	CIITA	40,45	PKCdelta	CIITA	5580	4261	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of PKCdelta in IFN-gamma-inducible CIITA gene expression .
16343435	0	PKCdelta	0,8	Cdk2	51,55	PKCdelta	Cdk2	5580	1017	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis .
11818507	0	PKCdelta	26,34	Janus_kinase_2	39,53	PKCdelta	Janus kinase 2	5580	3717	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Requirement of Ca -LRB- 2 + -RRB- and PKCdelta for Janus_kinase_2 activation by angiotensin_II : involvement of PYK2 .
17109817	0	PKCdelta	43,51	PKCalpha	15,23	PKCdelta	PKCalpha	5580	5578	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Involvement of PKCalpha in insulin-induced PKCdelta expression : Importance of SP-1_and_NFkappaB transcription factors .
16469949	0	PKCdelta	0,8	Smad3	26,31	PKCdelta	Smad3	18753(Tax:10090)	25631(Tax:10116)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|advcl|END_ENTITY	PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells .
19581935	0	PKCdelta	95,103	Syk	20,23	PKCdelta	Syk	5580	6850	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The tyrosine kinase Syk regulates the survival of chronic_lymphocytic_leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression .
19782747	0	PKCdelta	23,31	TNFalpha	0,8	PKCdelta	TNFalpha	5580	7124	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	TNFalpha activation of PKCdelta , mediated by NFkappaB and ER stress , cross-talks with the insulin signaling cascade .
15978696	0	PKCdelta	64,72	alpha-synuclein	10,25	PKCdelta	alpha-synuclein	5580	6622	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP + - induced apoptotic cell death .
11818507	0	PKCdelta	26,34	angiotensin_II	68,82	PKCdelta	angiotensin II	5580	183	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Requirement of Ca -LRB- 2 + -RRB- and PKCdelta for Janus_kinase_2 activation by angiotensin_II : involvement of PYK2 .
19897486	0	PKCdelta	52,60	c-Abl-protein_kinase_Cdelta	23,50	PKCdelta	c-Abl-protein kinase Cdelta	5580	5580	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Claudin-1 acts through c-Abl-protein_kinase_Cdelta -LRB- PKCdelta -RRB- signaling and has a causal role in the acquisition of invasive capacity in human liver cells .
12943720	0	PKCdelta	40,48	gonadotropin_releasing_hormone	69,99	PKCdelta	gonadotropin releasing hormone	5580	2796	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Activation and nuclear translocation of PKCdelta , Pyk2 and ERK1/2 by gonadotropin_releasing_hormone in HEK293 cells .
18295448	0	PKCdelta	0,8	hnRNP_K	109,116	PKCdelta	hnRNP K	18753(Tax:10090)	15387(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	PKCdelta regulates the stimulation of vascular endothelial factor mRNA translation by angiotensin II through hnRNP_K .
20548952	0	PKCdelta	97,105	hnRNP_K	16,23	PKCdelta	hnRNP K	18753(Tax:10090)	15387(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY apoptosis|nmod|translocation induces|dobj|apoptosis induces|nsubj|Inactivation Inactivation|nmod|END_ENTITY	Inactivation of hnRNP_K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar_ataxia_10 .
12379484	0	PKCdelta	60,68	p300	52,56	PKCdelta	p300	5580	2033	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Inhibition of histone acetyltransferase function of p300 by PKCdelta .
15601585	0	PKCdelta	0,8	p53	18,21	PKCdelta	p53	5580	7157	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	PKCdelta requires p53 for suppression of the transformed phenotype in human colon_cancer cells .
10713064	0	PKCdelta	39,47	protein_kinase_C_delta	15,37	PKCdelta	protein kinase C delta	5580	5580	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of protein_kinase_C_delta -LRB- PKCdelta -RRB- in phorbol_ester-induced apoptosis in LNCaP_prostate_cancer cells .
20198332	0	PKCepsilon	0,10	Bcl-2	19,24	PKCepsilon	Bcl-2	5581	596	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	PKCepsilon induces Bcl-2 by activating CREB .
16930532	0	PKCepsilon	21,31	Cdc42	0,5	PKCepsilon	Cdc42	5581	998	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Cdc42 is involved in PKCepsilon - and delta-induced neurite outgrowth and stress fibre dismantling .
19542546	0	PKCepsilon	30,40	MATER	0,5	PKCepsilon	MATER	5581	126206	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	MATER protein as substrate of PKCepsilon in human cumulus cells .
15375568	0	PKCepsilon	43,53	beta1_integrin	14,28	PKCepsilon	beta1 integrin	5581	3688	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of beta1_integrin expression by PKCepsilon in renal_cancer cells .
15649404	0	PKCepsilon	0,10	interleukin-6	19,32	PKCepsilon	interleukin-6	18754(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	PKCepsilon induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes .
15542537	0	PKCepsilon	34,44	protein_kinase_C-epsilon	8,32	PKCepsilon	protein kinase C-epsilon	29340(Tax:10116)	29340(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of protein_kinase_C-epsilon -LRB- PKCepsilon -RRB- in isoflurane-induced cardioprotection .
10438519	0	PKCepsilon	40,50	protein_kinase_Cepsilon	15,38	PKCepsilon	protein kinase Cepsilon	5581	5581	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of protein_kinase_Cepsilon -LRB- PKCepsilon -RRB- in thyroid cell death .
11839754	0	PKCepsilon	209,219	protein_kinase_Cepsilon	39,62	PKCepsilon	protein kinase Cepsilon	100009103(Tax:9986)	100009103(Tax:9986)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Nitric_oxide -LRB- NO -RRB- induces nitration of protein_kinase_Cepsilon -LRB- PKCepsilon -RRB- , facilitating PKCepsilon translocation via enhanced PKCepsilon - RACK2 interactions : a novel mechanism of no-triggered activation of PKCepsilon .
20421451	0	PKCgamma	15,23	Src	49,52	PKCgamma	Src	5582	6714	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic_retinal_neovascularization .
20978191	0	PKCzeta	45,52	Rictor	23,29	PKCzeta	Rictor	5590	253260	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis .
11755531	0	PKCzeta	33,40	p62	0,3	PKCzeta	p62	5590	23636	Gene	Gene	complex|nmod|START_ENTITY inhibition|amod|complex forms|dobj|inhibition forms|nsubj|END_ENTITY	p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition .
11755531	0	PKCzeta	81,88	p62	0,3	PKCzeta	p62	5590	23636	Gene	Gene	inhibition|compound|START_ENTITY forms|dobj|inhibition forms|nsubj|END_ENTITY	p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition .
16011831	0	PKCzeta	48,55	p62	0,3	PKCzeta	p62	5590	23636	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation .
16113073	0	PKCzeta	42,49	phospholipase_D	18,33	PKCzeta	phospholipase D	5590	2822	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	ANG II stimulates phospholipase_D through PKCzeta activation in VSMC : implications in adhesion , spreading , and hypertrophy .
21292998	0	PKD	69,72	COX-2	48,53	PKD	COX-2	5587	5743	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	TNF-a potentiates lysophosphatidic_acid-induced COX-2 expression via PKD in human colonic myofibroblasts .
16380231	0	PKD	26,29	PI3K	79,83	PKD	PI3K	5587	5293	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|END_ENTITY	Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K , Vav1 and PLCgamma .
8947045	0	PKD	18,21	Protein_kinase_D	0,16	PKD	Protein kinase D	18760(Tax:10090)	18760(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Protein_kinase_D -LRB- PKD -RRB- activation in intact cells through a protein kinase C-dependent signal transduction pathway .
22975325	0	PKD	0,3	Rabaptin-5	93,103	PKD	Rabaptin-5	5587	9135	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	PKD controls avb3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5 .
26797128	0	PKD1	0,4	AMPKa2	14,20	PKD1	AMPKa2	5310	5563	Gene	Gene	Inhibits|compound|START_ENTITY END_ENTITY|nsubj|Inhibits	PKD1 Inhibits AMPKa2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells .
9171830	0	PKD1	0,4	PKD2	20,24	PKD1	PKD2	5310	5311	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PKD1 interacts with PKD2 through a probable coiled-coil domain .
23129748	0	PKD1	37,41	PTEN	14,18	PKD1	PTEN	5310	5728	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of PTEN activity by p38 - PKD1 signaling in neutrophils confers inflammatory responses in the lung .
10504485	0	PKD1	27,31	Polycystin-1	0,12	PKD1	Polycystin-1	5310	5310	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Polycystin-1 expression in PKD1 , early-onset PKD1 , and TSC2/PKD1 cystic tissue .
21696630	0	PKD1	19,23	Protein_kinase_D1	0,17	PKD1	Protein kinase D1	5587	5587	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Protein_kinase_D1 -LRB- PKD1 -RRB- activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal_degeneration .
24806360	0	PKD1	19,23	Protein_kinase_D1	0,17	PKD1	Protein kinase D1	5587	5587	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Protein_kinase_D1 -LRB- PKD1 -RRB- phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress .
12007403	0	PKD1	0,4	p21	13,16	PKD1	p21	18763(Tax:10090)	12575(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PKD1 induces p21 -LRB- waf1 -RRB- and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2 .
1349580	0	PKD1	76,80	polycystic_kidney_disease	44,69	PKD1	polycystic kidney disease	18763(Tax:10090)	18763(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human-mouse homologies in the region of the polycystic_kidney_disease gene -LRB- PKD1 -RRB- .
7896286	0	PKD1	80,84	polycystic_kidney_disease	48,73	PKD1	polycystic kidney disease	5310	5310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel cyclin gene -LRB- CCNF -RRB- in the region of the polycystic_kidney_disease gene -LRB- PKD1 -RRB- .
9521593	0	PKD1	37,41	polycystic_kidney_disease	43,68	PKD1	polycystic kidney disease	5310	5310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel and recurrent mutations in the PKD1 -LRB- polycystic_kidney_disease -RRB- gene .
14596619	0	PKD1	95,99	polycystic_kidney_disease-1	66,93	PKD1	polycystic kidney disease-1	5310	5310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transmembrane domain analysis of polycystin-1 , the product of the polycystic_kidney_disease-1 -LRB- PKD1 -RRB- gene : evidence for 11 membrane-spanning domains .
10923038	0	PKD1	60,64	polycystic_kidney_disease_1	31,58	PKD1	polycystic kidney disease 1	5310	5310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Screening the 3 ' region of the polycystic_kidney_disease_1 -LRB- PKD1 -RRB- gene in 41 Bulgarian and Australian kindreds reveals a prevalence of protein truncating mutations .
14695542	0	PKD1	52,56	polycystic_kidney_disease_1	23,50	PKD1	polycystic kidney disease 1	5310	5310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Large deletions in the polycystic_kidney_disease_1 -LRB- PKD1 -RRB- gene .
7835880	0	PKD1	60,64	polycystic_kidney_disease_1	31,58	PKD1	polycystic kidney disease 1	5310	5310	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	A large duplicated area in the polycystic_kidney_disease_1 -LRB- PKD1 -RRB- region of chromosome 16 is prone to rearrangement .
10532593	0	PKD1	4,8	polycystin-1	24,36	PKD1	polycystin-1	5310	5310	Gene	Gene	product|compound|START_ENTITY product|dep|END_ENTITY	The PKD1 gene product , `` polycystin-1 , '' is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal_epithelia .
10760273	0	PKD2	38,42	Hax-1	58,63	PKD2	Hax-1	5311	10456	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The polycystic_kidney_disease protein PKD2 interacts with Hax-1 , a protein associated with the actin cytoskeleton .
19192391	0	PKD2	0,4	Lck	20,23	PKD2	Lck	25865	3932	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PKD2 interacts with Lck and regulates NFAT activity in T cells .
9171830	0	PKD2	20,24	PKD1	0,4	PKD2	PKD1	5311	5310	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PKD1 interacts with PKD2 through a probable coiled-coil domain .
15123714	0	PKD2	0,4	mDia1	37,42	PKD2	mDia1	5311	13367(Tax:10090)	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells : role of mDia1 IN PKD2 localization to mitotic spindles .
9773786	0	PKD2	60,64	polycystic_kidney_disease-2	31,58	PKD2	polycystic kidney disease-2	5311	5311	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A spectrum of mutations in the polycystic_kidney_disease-2 -LRB- PKD2 -RRB- gene from eight Canadian kindreds .
11438989	0	PKD2	52,56	polycystic_kidney_disease_2	23,50	PKD2	polycystic kidney disease 2	5311	5311	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations of the human polycystic_kidney_disease_2 -LRB- PKD2 -RRB- gene .
23315160	0	PKD2	83,87	polycystic_kidney_disease_2	54,81	PKD2	polycystic kidney disease 2	641309(Tax:9823)	641309(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Construction of a transgenic pig model overexpressing polycystic_kidney_disease_2 -LRB- PKD2 -RRB- gene .
9573526	0	PKD2	98,102	polycystic_kidney_disease_2	69,96	PKD2	polycystic kidney disease 2	5311	5311	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel frameshift mutation induced by an adenosine insertion in the polycystic_kidney_disease_2 -LRB- PKD2 -RRB- gene .
24337579	0	PKD3	28,32	protein_kinase_D3	9,26	PKD3	protein kinase D3	23683	23683	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Elevated protein_kinase_D3 -LRB- PKD3 -RRB- expression supports proliferation of triple-negative_breast_cancer cells and contributes to mTORC1-S6K1 pathway activation .
16885398	0	PKG	54,57	PLC-beta1	32,41	PKG	PLC-beta1	5592	23236	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of Galphaq-dependent PLC-beta1 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2 .
9698155	0	PKIalpha	39,47	protein_kinase_A	11,27	PKIalpha	protein kinase A	114906(Tax:10116)	25636(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Endogenous protein_kinase_A inhibitor -LRB- PKIalpha -RRB- modulates synaptic activity .
21975456	0	PKM	130,133	Nerve_growth_factor	0,19	PKM	Nerve growth factor	25630(Tax:10116)	310738(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Nerve_growth_factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform , PKM .
24058603	0	PKM2	41,45	BRCA1	20,25	PKM2	BRCA1	5315	672	Gene	Gene	TOPOI|appos|START_ENTITY TOPOI|compound|END_ENTITY	Predictive value of BRCA1 , ERCC1 , ATP7B , PKM2 , TOPOI , TOP - IIA , TOPOIIB and C-MYC genes in patients with small_cell_lung_cancer -LRB- SCLC -RRB- who received first line therapy with cisplatin and etoposide .
25446258	0	PKM2	68,72	ECM1	0,4	PKM2	ECM1	5315	1893	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2 .
25289083	0	PKM2	0,4	Gli1	15,19	PKM2	Gli1	5315	2735	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	PKM2 regulates Gli1 expression in hepatocellular_carcinoma .
26739387	0	PKM2	0,4	HIF-1a	47,53	PKM2	HIF-1a	5315	3091	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	PKM2 promotes tumor angiogenesis by regulating HIF-1a through NF-kB activation .
26385349	0	PKM2	36,40	Pyruvate_Kinase_Muscle_Isoenzyme_2	0,34	PKM2	Pyruvate Kinase Muscle Isoenzyme 2	5315	5315	Gene	Gene	Expression|appos|START_ENTITY Expression|amod|END_ENTITY	Pyruvate_Kinase_Muscle_Isoenzyme_2 -LRB- PKM2 -RRB- Expression Is Associated with Overall Survival in Pancreatic_Ductal_Adenocarcinoma .
21826988	0	PKM2	72,76	endostatin	94,104	PKM2	endostatin	18746(Tax:10090)	12822(Tax:10090)	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Antitumor effect by combination of shRNA interfering plasmid targeting PKM2 with recombinant endostatin -RSB- .
26546436	0	PKM2	53,57	miR-122	0,7	PKM2	miR-122	5315	406906	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-122 inhibits cancer_cell_malignancy by targeting PKM2 in gallbladder_carcinoma .
21277858	0	PKN	32,35	PKN-1	0,5	PKN	PKN-1	5585	5585	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	PKN-1 , a homologue of mammalian PKN , is involved in the regulation of muscle contraction and force transmission in C. _ elegans .
17374997	0	PKN	0,3	TGF-beta_1	54,64	PKN	TGF-beta 1	5585	7040	Gene	Gene	activation|compound|START_ENTITY activation|nmod|receptor receptor|compound|END_ENTITY	PKN activation via transforming growth factor-beta 1 -LRB- TGF-beta_1 -RRB- receptor signaling delays G2/M phase transition in vascular smooth muscle cells .
9030526	0	PKN	15,18	alpha-actinin	24,37	PKN	alpha-actinin	5585	87	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of PKN with alpha-actinin .
9637778	0	PKN	0,3	paraneoplastic_cerebellar_degeneration-associated_antigen	21,78	PKN	paraneoplastic cerebellar degeneration-associated antigen	5585	1039	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PKN interacts with a paraneoplastic_cerebellar_degeneration-associated_antigen , which is a potential transcription factor .
11259428	0	PKN	0,3	phospholipase_D1	14,30	PKN	phospholipase D1	5585	5337	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PKN regulates phospholipase_D1 through direct interaction .
9175763	0	PKN	83,86	vimentin	35,43	PKN	vimentin	5585	7431	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Domain-specific phosphorylation of vimentin and glial_fibrillary_acidic_protein by PKN .
21277858	0	PKN-1	0,5	PKN	32,35	PKN-1	PKN	5585	5585	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	PKN-1 , a homologue of mammalian PKN , is involved in the regulation of muscle contraction and force transmission in C. _ elegans .
11070079	0	PKR	172,175	ADAR1	58,63	PKR	ADAR1	5610	103	Gene	Gene	reveal|nmod|START_ENTITY reveal|nsubj|proteins proteins|compound|END_ENTITY	Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR .
19605474	0	PKR	21,24	ADAR1	0,5	PKR	ADAR1	5610	103	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ADAR1 interacts with PKR during human immunodeficiency virus_infection of lymphocytes and contributes to viral replication .
19710021	0	PKR	115,118	ADAR1	33,38	PKR	ADAR1	5610	103	Gene	Gene	apoptosis|nmod|START_ENTITY suppresses|dobj|apoptosis suppresses|nsubj|END_ENTITY	RNA-specific adenosine deaminase ADAR1 suppresses measles_virus-induced apoptosis and activation of protein kinase PKR .
19913273	0	PKR	89,92	ADAR1	24,29	PKR	ADAR1	5610	103	Gene	Gene	activation|nmod|START_ENTITY leads|nmod|activation leads|nsubj|deficiency deficiency|compound|END_ENTITY	RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular_stomatitis virus growth following interferon treatment .
25389016	0	PKR	67,70	ADAR1	0,5	PKR	ADAR1	5610	103	Gene	Gene	activity|compound|START_ENTITY inhibition|nmod|activity enhances|nmod|inhibition enhances|nsubj|END_ENTITY	ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity .
11342638	0	PKR	29,32	IFN-gamma	77,86	PKR	IFN-gamma	5610	3458	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	RNA-dependent protein kinase PKR is required for activation of NF-kappa_B by IFN-gamma in a STAT1-independent pathway .
12936994	0	PKR	97,100	MxA	59,62	PKR	MxA	5610	4599	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Antiviral effects of geranylgeranylacetone : enhancement of MxA expression and phosphorylation of PKR during influenza_virus_infection .
10723127	0	PKR	64,67	NF-kappa_B	14,24	PKR	NF-kappa B	5610	4790	Gene	Gene	involves|nsubj|START_ENTITY involves|advcl|Activation Activation|nmod|END_ENTITY	Activation of NF-kappa_B by the dsRNA-dependent protein kinase , PKR involves the I kappa B kinase complex .
11342638	0	PKR	29,32	NF-kappa_B	63,73	PKR	NF-kappa B	5610	4790	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	RNA-dependent protein kinase PKR is required for activation of NF-kappa_B by IFN-gamma in a STAT1-independent pathway .
15121867	0	PKR	26,29	NF-kappa_B	35,45	PKR	NF-kappa B	5610	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	TRAF family proteins link PKR with NF-kappa_B activation .
18835251	0	PKR	21,24	Nck-1	0,5	PKR	Nck-1	5610	4690	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nck-1 interacts with PKR and modulates its activation by dsRNA .
26446704	0	PKR	10,13	P53	102,105	PKR	P53	5610	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|stabilization stabilization|nmod|END_ENTITY	Activated PKR inhibits pancreatic b-cell proliferation through sumoylation-dependent stabilization of P53 .
8990167	0	PKR	90,93	P58IPK	56,62	PKR	P58IPK	5610	5611	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	The molecular chaperone hsp40 regulates the activity of P58IPK , the cellular inhibitor of PKR .
11238927	0	PKR	71,74	PACT	21,25	PKR	PACT	5610	5930	Gene	Gene	domains|nmod|START_ENTITY structure|dep|domains structure|nmod|END_ENTITY	Modular structure of PACT : distinct domains for binding and activating PKR .
11985496	0	PKR	159,162	PACT	63,67	PKR	PACT	5610	8575	Gene	Gene	kinase|appos|START_ENTITY activation|nmod|kinase role|nmod|activation plays|dobj|role plays|nsubj|motif motif|nmod|END_ENTITY	The C-terminal , third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase -LRB- PKR -RRB- .
14585331	0	PKR	74,77	PACT	35,39	PKR	PACT	5610	8575	Gene	Gene	activity|compound|START_ENTITY effects|nmod|activity have|dobj|effects have|nsubj|motifs motifs|nmod|END_ENTITY	The carboxy-terminal , M3 motifs of PACT and TRBP have opposite effects on PKR activity .
16466763	0	PKR	48,51	PACT	104,108	PKR	PACT	5610	8575	Gene	Gene	protein|nmod|START_ENTITY Binding|nmod|protein mediates|nsubj|Binding mediates|nmod|END_ENTITY	Binding of the influenza_A_virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA .
16785445	0	PKR	20,23	PACT	38,42	PKR	PACT	5610	5930	Gene	Gene	basis|nmod|START_ENTITY activation|nsubj|basis activation|nmod|END_ENTITY	Molecular basis for PKR activation by PACT or dsRNA .
16982605	0	PKR	51,54	PACT	76,80	PKR	PACT	5610	8575	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Phosphorylation of specific serine residues in the PKR activation domain of PACT is essential for its ability to mediate apoptosis .
19580324	0	PKR	24,27	PACT	42,46	PKR	PACT	5610	5930	Gene	Gene	analysis|nmod|START_ENTITY activation|nsubj|analysis activation|nmod|END_ENTITY	Biochemical analysis of PKR activation by PACT .
22473766	0	PKR	91,94	PACT	30,34	PKR	PACT	5610	8575	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|interaction interaction|nmod|molecules molecules|amod|END_ENTITY	Increased interaction between PACT molecules in response to stress signals is required for PKR activation .
24020926	0	PKR	35,38	PACT	19,23	PKR	PACT	5610	8575	Gene	Gene	inhibitor|compound|START_ENTITY becomes|xcomp|inhibitor becomes|nsubj|activator activator|appos|END_ENTITY	The PKR activator , PACT , becomes a PKR inhibitor during HIV-1 replication .
24020926	0	PKR	4,7	PACT	19,23	PKR	PACT	5610	8575	Gene	Gene	activator|compound|START_ENTITY activator|appos|END_ENTITY	The PKR activator , PACT , becomes a PKR inhibitor during HIV-1 replication .
26231208	0	PKR	37,40	PACT	127,131	PKR	PACT	5610	8575	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|cells cells|acl|carrying carrying|dobj|mutation mutation|nmod|END_ENTITY	Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT .
26231208	0	PKR	37,40	PACT	127,131	PKR	PACT	5610	8575	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|cells cells|acl|carrying carrying|dobj|mutation mutation|nmod|END_ENTITY	Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT .
15299031	0	PKR	69,72	RAX	29,32	PKR	RAX	5610	30062	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|phosphorylation phosphorylation|nmod|END_ENTITY	Serine 18 phosphorylation of RAX , the PKR activator , is required for PKR activation and consequent translation inhibition .
19229320	0	PKR	34,37	RNA_helicase_A	61,75	PKR	RNA helicase A	5610	1660	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	An antiviral response directed by PKR phosphorylation of the RNA_helicase_A .
26052716	0	PKR	27,30	Serum_Amyloid_A	0,15	PKR	Serum Amyloid A	5610	6287	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Serum_Amyloid_A Stimulates PKR Expression and HMGB1 Release Possibly through TLR4/RAGE Receptors .
12475984	0	PKR	172,175	TRBP	29,33	PKR	TRBP	5610	6895	Gene	Gene	inhibit|dobj|START_ENTITY ability|acl|inhibit expression|nmod|ability stimulates|dobj|expression stimulates|nsubj|protein protein|appos|END_ENTITY	The TAR RNA-binding protein , TRBP , stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR .
16142218	0	PKR	30,33	TRBP	0,4	PKR	TRBP	5610	6896	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	TRBP , a regulator of cellular PKR and HIV-1 virus expression , interacts with Dicer and functions in RNA silencing .
16188979	0	PKR	112,115	TRBP	4,8	PKR	TRBP	5610	6895	Gene	Gene	response|compound|START_ENTITY enhancing|dobj|response support|advcl|enhancing support|nsubj|levels levels|compound|END_ENTITY	Low TRBP levels support an innate human_immunodeficiency_virus_type_1 resistance in astrocytes by enhancing the PKR antiviral response .
21937648	0	PKR	150,153	TRBP	38,42	PKR	TRBP	5610	6896	Gene	Gene	activation|nmod|START_ENTITY inhibiting|dobj|activation promotes|advcl|inhibiting promotes|nsubj|protein protein|appos|END_ENTITY	The cellular TAR RNA binding protein , TRBP , promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR .
25843719	0	PKR	20,23	TRBP	39,43	PKR	TRBP	19106(Tax:10090)	21357(Tax:10090)	Gene	Gene	Complexes|compound|START_ENTITY Complexes|nmod|END_ENTITY	A Critical Role for PKR Complexes with TRBP in Immunometabolic Regulation and eIF2a Phosphorylation in Obesity .
9034343	0	PKR	117,120	TRBP	47,51	PKR	TRBP	5610	6895	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|potential potential|nmod|END_ENTITY	Oncogenic potential of TAR_RNA_binding_protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR .
23392680	0	PKR	27,30	eIF2a	13,18	PKR	eIF2a	54287(Tax:10116)	54318(Tax:10116)	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Blocking the eIF2a kinase -LRB- PKR -RRB- enhances positive and negative forms of cortex-dependent taste memory .
11179981	0	PKR	92,95	eIF2alpha	182,191	PKR	eIF2alpha	5610	83939	Gene	Gene	kinase|appos|START_ENTITY N-terminus|nmod|kinase sequences|nmod|N-terminus important|nsubj|sequences important|advcl|regulating regulating|dobj|phosphorylation phosphorylation|nmod|2alpha 2alpha|appos|END_ENTITY	Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase , PKR , are important for regulating phosphorylation of eukaryotic initiation factor 2alpha -LRB- eIF2alpha -RRB- .
16179258	0	PKR	84,87	eIF2alpha	38,47	PKR	eIF2alpha	5610	83939	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|recognition recognition|nmod|END_ENTITY	Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR .
16391235	0	PKR	141,144	eIF2alpha	52,61	PKR	eIF2alpha	5610	83939	Gene	Gene	effect|nmod|START_ENTITY overcome|dobj|effect strategy|acl|overcome resistance|dep|strategy resistance|nmod|mRNA mRNA|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation : a strategy to overcome the antiviral effect of protein kinase PKR .
17715234	0	PKR	69,72	eIF2alpha	55,64	PKR	eIF2alpha	5610	83939	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation , which can be overcome by helper adenovirus_type_5 virus-associated RNA .
19587046	0	PKR	176,179	eIF2alpha	10,19	PKR	eIF2alpha	19106(Tax:10090)	83939	Gene	Gene	ICP34|compound|START_ENTITY accumulation|nmod|ICP34 fibroblasts|nmod|accumulation mutants|nmod|fibroblasts replication|nmod|mutants attenuates|dobj|replication attenuates|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Increased eIF2alpha phosphorylation attenuates replication of herpes_simplex_virus_2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34 .5 .
9431994	0	PKR	213,216	eIF2alpha	89,98	PKR	eIF2alpha	5610	83939	Gene	Gene	kinase|appos|START_ENTITY domain|nmod|kinase interact|nmod|domain interact|nsubj|regions regions|nmod|subunit subunit|nmod|END_ENTITY	Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 -LRB- eIF2alpha -RRB- and the vaccinia_virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase -LRB- PKR -RRB- .
11432733	0	PKR	151,154	eukaryotic_initiation_factor-2	174,204	PKR	eukaryotic initiation factor-2	5610	8894	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Mechanism of activation of the double-stranded-RNA-dependent protein kinase , PKR : role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic_initiation_factor-2 -LRB- eIF2 -RRB- .
11432733	0	PKR	77,80	eukaryotic_initiation_factor-2	174,204	PKR	eukaryotic initiation factor-2	5610	8894	Gene	Gene	kinase|appos|START_ENTITY activation|nmod|kinase Mechanism|nmod|activation Mechanism|dep|role role|nmod|localization localization|nmod|stimulation stimulation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Mechanism of activation of the double-stranded-RNA-dependent protein kinase , PKR : role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic_initiation_factor-2 -LRB- eIF2 -RRB- .
7568028	0	PKR	56,59	interferon	63,73	PKR	interferon	5610	3439	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity .
10082513	0	PKR	45,48	p53	105,108	PKR	p53	19106(Tax:10090)	22060(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53 .
10348343	0	PKR	49,52	p53	101,104	PKR	p53	5610	7157	Gene	Gene	associates|compound|START_ENTITY associates|nmod|protein protein|compound|END_ENTITY	The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro .
19210572	0	PKR	0,3	p53	99,102	PKR	p53	5610	7157	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|translation translation|nmod|END_ENTITY	PKR , a cognitive_decline biomarker , can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients .
19416861	0	PKR	0,3	p53	7,10	PKR	p53	5610	7157	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	PKR , a p53 target gene , plays a crucial role in the tumor-suppressor function of p53 .
19416861	0	PKR	0,3	p53	81,84	PKR	p53	5610	7157	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|function function|nmod|END_ENTITY	PKR , a p53 target gene , plays a crucial role in the tumor-suppressor function of p53 .
19631745	0	PKR	36,39	p53	101,104	PKR	p53	5610	7157	Gene	Gene	pathways|compound|START_ENTITY links|nmod|pathways Evidence|nmod|links Evidence|dep|role role|nmod|END_ENTITY	Evidence of molecular links between PKR and mTOR signalling pathways in Abeta neurotoxicity : role of p53 , Redd1 and TSC2 .
19838063	0	PKR	0,3	p53	50,53	PKR	p53	5610	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress .
11123929	0	PKR	57,60	p67	90,93	PKR	p67	5610	945	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular glycoprotein p67 .
20538047	0	PKR-like_endoplasmic_reticulum_kinase	0,37	PERK	39,43	PKR-like endoplasmic reticulum kinase	PERK	9451	9451	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	PKR-like_endoplasmic_reticulum_kinase -LRB- PERK -RRB- activation following brain_ischemia is independent of unfolded nascent proteins .
9373137	0	PKY	37,40	Yak1	154,158	PKY	Yak1	10114	853300(Tax:4932)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and sequence of human PKY , a putative kinase with increased expression in multidrug-resistant cells , with homology to yeast protein kinase Yak1 .
15705408	0	PLA2	15,19	ITGB3	40,45	PLA2	ITGB3	5319	3690	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Association of PLA2 polymorphism of the ITGB3 gene with early fetal loss .
10421488	0	PLA2	18,22	Phospholipase_A2	0,16	PLA2	Phospholipase A2	445525(Tax:9823)	445525(Tax:9823)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Phospholipase_A2 -LRB- PLA2 -RRB- activity in mini pigs after acute high dose i.v.-paraoxon -LRB- POX -RRB- intoxication .
1793014	0	PLA2	18,22	Phospholipase_A2	0,16	PLA2	Phospholipase A2	104974671	104974671	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Phospholipase_A2 -LRB- PLA2 -RRB- activity in bovine pulmonary artery endothelial cells .
8358004	0	PLA2	18,22	Phospholipase_A2	0,16	PLA2	Phospholipase A2	151056	151056	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Phospholipase_A2 -LRB- PLA2 -RRB- activity in gerbil brain : characterization of cytosolic and membrane-associated forms and effects of ischemia and reperfusion on enzymatic activity .
9486135	0	PLA2	61,65	Thrombin	0,8	PLA2	Thrombin	151056	2147	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Thrombin activates a membrane-associated calcium-independent PLA2 in ventricular myocytes .
1706672	0	PLA2	59,63	phospholipase_A2	41,57	PLA2	phospholipase A2	151056	151056	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The diagnostic value of serum pancreatic phospholipase_A2 -LRB- PLA2 -RRB- in pancreatic_diseases .
1847770	0	PLA2	89,93	phospholipase_A2	71,87	PLA2	phospholipase A2	151056	151056	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	A novel mechanism of glucocorticosteroid -LRB- GC -RRB- action in suppression of phospholipase_A2 -LRB- PLA2 -RRB- activity stimulated by Ca2 + ionophore A23187 : induction of protein phosphatases .
19747452	0	PLA2	63,67	phospholipase_A2	45,61	PLA2	phospholipase A2	151056	151056	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Assembly of an intact Golgi complex requires phospholipase_A2 -LRB- PLA2 -RRB- activity , membrane tubules , and dynein-mediated microtubule transport .
2011718	0	PLA2	46,50	phospholipase_A2	28,44	PLA2	phospholipase A2	151056	151056	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Immunoregulatory effects of phospholipase_A2 -LRB- PLA2 -RRB- on the proliferation of human lymphocytes .
2045888	0	PLA2	38,42	phospholipase_A2	20,36	PLA2	phospholipase A2	151056	151056	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Characterization of phospholipase_A2 -LRB- PLA2 -RRB- activity in gerbil brain : enhanced activities of cytosolic , mitochondrial , and microsomal forms after ischemia and reperfusion .
3115895	0	PLA2	32,36	phospholipase_A2	14,30	PLA2	phospholipase A2	18784(Tax:10090)	18784(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of phospholipase_A2 -LRB- PLA2 -RRB- activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity .
8005604	0	PLA2	60,64	phospholipase_A2	42,58	PLA2	phospholipase A2	151056	151056	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	TaqI dimorphic site in a human pancreatic phospholipase_A2 -LRB- PLA2 -RRB- gene localized on chromosome 12 .
8234286	0	PLA2	51,55	phospholipase_A2	33,49	PLA2	phospholipase A2	151056	151056	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Inhibition of endosome fusion by phospholipase_A2 -LRB- PLA2 -RRB- inhibitors points to a role for PLA2 in endocytosis .
9139985	0	PLA2	104,108	thrombin	64,72	PLA2	thrombin	151056	2147	Gene	Gene	activation|dep|START_ENTITY activation|compound|END_ENTITY	Lysophosphatidylcholine accumulation in cardiomyocytes requires thrombin activation of Ca2 + - independent PLA2 .
23609358	0	PLA2G2A	53,60	phospholipase_A2_group_IIA	25,51	PLA2G2A	phospholipase A2 group IIA	5320	5320	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinical significance of phospholipase_A2_group_IIA -LRB- PLA2G2A -RRB- expression in primary resected esophageal_squamous_cell_carcinoma .
24641411	0	PLA2G2A	134,141	prostaglandin-endoperoxide_synthase_2	54,91	PLA2G2A	prostaglandin-endoperoxide synthase 2	5320	5743	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Association of single nucleotide polymorphisms in the prostaglandin-endoperoxide_synthase_2 -LRB- PTGS2 -RRB- and phospholipase A group IIA -LRB- PLA2G2A -RRB- genes with susceptibility to esophageal_squamous_cell_carcinoma .
26568247	0	PLAC8	38,43	FAIM3	32,37	PLAC8	FAIM3	51316	9214	Gene	Gene	Ratio|compound|START_ENTITY Validation|dep|Ratio Validation|nmod|END_ENTITY	Comprehensive Validation of the FAIM3 : PLAC8 Ratio in Time-matched Public Gene Expression Data .
26568248	0	PLAC8	45,50	FAIM3	39,44	PLAC8	FAIM3	51316	9214	Gene	Gene	Ratio|compound|START_ENTITY Reply|dep|Ratio Reply|dep|Validation Validation|nmod|END_ENTITY	Reply : Comprehensive Validation of the FAIM3 : PLAC8 Ratio in Time-matched Public Gene Expression Data .
26720791	0	PLAC8	6,11	FAIM3	0,5	PLAC8	FAIM3	51316	9214	Gene	Gene	Ratio|compound|START_ENTITY END_ENTITY|dep|Ratio	FAIM3 : PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired_Pneumonia : Comparing Apples to Oranges ?
26720792	0	PLAC8	13,18	FAIM3	7,12	PLAC8	FAIM3	51316	9214	Gene	Gene	Ratio|compound|START_ENTITY END_ENTITY|dep|Ratio	Reply : FAIM3 : PLAC8 Ratio Compared with Existing Biomarkers for Diagnosis of Severe Community-acquired_Pneumonia : Comparing Apples to Oranges ?
24700772	0	PLAG1	75,80	COL3A1	18,24	PLAG1	COL3A1	5324	1281	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma .
10646861	0	PLAG1	0,5	IGF-II	111,117	PLAG1	IGF-II	5324	3481	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PLAG1 , the main translocation target in pleomorphic_adenoma of the salivary glands , is a positive regulator of IGF-II .
21294959	0	PLAG1	28,33	Pdx1	0,4	PLAG1	Pdx1	56711(Tax:10090)	18609(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Pdx1 - and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads_to_endocrine_hormone_imbalances that affect glucose metabolism .
27013583	0	PLAG1	86,91	TRAIL	29,34	PLAG1	TRAIL	5324	8743	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	MiR-424 and miR-27a increase TRAIL sensitivity of acute_myeloid_leukemia by targeting PLAG1 .
11882654	0	PLAG1	60,65	karyopherin_alpha_2	20,39	PLAG1	karyopherin alpha 2	5324	3838	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Identification of a karyopherin_alpha_2 recognition site in PLAG1 , which functions as a nuclear localization signal .
8653285	0	PLAP	48,52	alkaline_phosphatase	26,46	PLAP	alkaline phosphatase	250	250	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of placental alkaline_phosphatase -LRB- PLAP -RRB- in the monitoring of patients with seminoma .
9049616	0	PLAP	48,52	placental_alkaline_phosphatase	16,46	PLAP	placental alkaline phosphatase	250	250	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Distribution of placental_alkaline_phosphatase -LRB- PLAP -RRB- gene frequencies in Andhra Pradesh -LRB- south India -RRB- .
9387432	0	PLAP	50,54	placental_alkaline_phosphatase	18,48	PLAP	placental alkaline phosphatase	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of placental_alkaline_phosphatase -LRB- PLAP -RRB- for detecting the damages of alveolar type I cells caused by smoke_inhalation -RSB- .
26399972	0	PLAP-1	0,6	Asporin	7,14	PLAP-1	Asporin	54829	54829	Gene	Gene	START_ENTITY|appos|Regulates Regulates|nsubj|END_ENTITY	PLAP-1 / Asporin Regulates TLR2 - and TLR4-induced Inflammatory Responses .
18988861	0	PLAU	80,84	urokinase_plasminogen_activator	42,73	PLAU	urokinase plasminogen activator	5328	5328	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Quebec_platelet_disorder is linked to the urokinase_plasminogen_activator gene -LRB- PLAU -RRB- and increases expression of the linked allele in megakaryocytes .
24316392	0	PLC	52,55	E-cadherin	18,28	PLC	E-cadherin	3339	999	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	A new PKCa/b/TBX3 / E-cadherin pathway is involved in PLC - regulated invasion and migration in human bladder_cancer cells .
24228869	0	PLC	91,94	PK-C	105,109	PLC	PK-C	32601(Tax:7227)	43428(Tax:7227)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Vitellogenesis in the fruit_fly , Drosophila_melanogaster : antagonists demonstrate that the PLC , IP3/DAG , PK-C pathway is triggered by calmodulin .
16000869	0	PLC	95,98	phospholipase_C-gamma1	46,68	PLC	phospholipase C-gamma1	3339	5335	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Inositol 5 ' - phosphatase , SHIP1 interacts with phospholipase_C-gamma1 and modulates EGF-induced PLC activity .
16885398	0	PLC-beta1	32,41	PKG	54,57	PLC-beta1	PKG	23236	5592	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Inhibition of Galphaq-dependent PLC-beta1 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2 .
24962066	0	PLC-beta_1	0,10	miR-210	39,46	PLC-beta 1	miR-210	23236	406992	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	PLC-beta_1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells .
9808840	0	PLC-gamma1	32,42	Fibroblast_growth_factor_2	0,26	PLC-gamma1	Fibroblast growth factor 2	5335	2247	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Fibroblast_growth_factor_2 uses PLC-gamma1 for cell proliferation and PI3-kinase for alteration of cell shape and cell proliferation in corneal endothelial cells .
10692443	0	PLC-gamma1	144,154	PLC-gamma1	76,86	PLC-gamma1	PLC-gamma1	5335	5335	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Differential roles of the Src homology 2 domains of phospholipase_C-gamma1 -LRB- PLC-gamma1 -RRB- in platelet-derived growth factor-induced activation of PLC-gamma1 in intact cells .
10692443	0	PLC-gamma1	76,86	PLC-gamma1	144,154	PLC-gamma1	PLC-gamma1	5335	5335	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Differential roles of the Src homology 2 domains of phospholipase_C-gamma1 -LRB- PLC-gamma1 -RRB- in platelet-derived growth factor-induced activation of PLC-gamma1 in intact cells .
9003510	0	PLCB3	67,72	phospholipase_C_beta_3	43,65	PLCB3	phospholipase C beta 3	5331	5331	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Exclusion of the phosphoinositide-specific phospholipase_C_beta_3 -LRB- PLCB3 -RRB- gene as a candidate for multiple_endocrine_neoplasia_type_1 .
24766303	0	PLCE1	0,5	p53	17,20	PLCE1	p53	51196	7157	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	PLCE1 suppresses p53 expression in esophageal_cancer cells .
26474454	0	PLCG1	25,30	Phospholipase_C_gamma_1	0,23	PLCG1	Phospholipase C gamma 1	5335	5335	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Phospholipase_C_gamma_1 -LRB- PLCG1 -RRB- R707Q mutation is counterselected under targeted therapy in a patient with hepatic_angiosarcoma .
11409699	0	PLCG1	33,38	phospholipase_C-gamma1	4,26	PLCG1	phospholipase C-gamma1	5335	5335	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The phospholipase_C-gamma1 gene -LRB- PLCG1 -RRB- and lithium-responsive bipolar_disorder : re-examination of an intronic dinucleotide repeat polymorphism .
12717426	0	PLC_gamma_1	18,29	Cbl	6,9	PLC gamma 1	Cbl	5335	867	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	70Z/3 Cbl induces PLC_gamma_1 activation in T lymphocytes via an alternate Lat - and Slp-76-independent signaling mechanism .
12374773	0	PLC_gamma_1	46,57	early_growth_response_1	79,102	PLC gamma 1	early growth response 1	25738(Tax:10116)	24330(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	Negative regulatory role of overexpression of PLC_gamma_1 in the expression of early_growth_response_1 gene in rat 3Y1 fibroblasts .
1533389	0	PLC_gamma_1	51,62	phospholipase_C-gamma_1	26,49	PLC gamma 1	phospholipase C-gamma 1	5335	5335	Gene	Gene	tyrosine|appos|START_ENTITY tyrosine|amod|END_ENTITY	Regulation of CD3-induced phospholipase_C-gamma_1 -LRB- PLC_gamma_1 -RRB- tyrosine phosphorylation by CD4 and CD45 receptors .
26217938	0	PLCb1	28,33	BMP-2	0,5	PLCb1	BMP-2	18795(Tax:10090)	12156(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	BMP-2 Induced Expression of PLCb1 That Is a Positive Regulator of Osteoblast Differentiation .
26490115	0	PLCb3	0,5	WAVE2	42,47	PLCb3	WAVE2	5331	10163	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	PLCb3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration .
9846483	0	PLCgamma1	47,56	LAT	0,3	PLCgamma1	LAT	5335	27040	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway .
14568990	0	PLCgamma1	42,51	insulin_receptor	80,96	PLCgamma1	insulin receptor	5335	3643	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin_receptor .
15259021	0	PLCgamma2	0,9	Bcl-2	20,25	PLCgamma2	Bcl-2	234779(Tax:10090)	12043(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	PLCgamma2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells .
12730118	0	PLCgamma2	51,60	GPVI	7,11	PLCgamma2	GPVI	234779(Tax:10090)	243816(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Murine GPVI stimulates weak integrin activation in PLCgamma2 - / - platelets : involvement of PLCgamma1 and PI3-kinase .
17431093	0	PLD	54,57	phospholipase_D	14,29	PLD	phospholipase D	2822	2822	Gene	Gene	involvement|compound|START_ENTITY END_ENTITY|dep|involvement	Understanding phospholipase_D -LRB- PLD -RRB- using leukocytes : PLD involvement in cell adhesion and chemotaxis .
24590739	0	PLD	59,62	phospholipase_D	42,57	PLD	phospholipase D	2822	2822	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Cloning and molecular characterization of phospholipase_D -LRB- PLD -RRB- delta gene from longan -LRB- Dimocarpus longan Lour . -RRB- .
8753790	0	PLD	49,52	phospholipase_D	32,47	PLD	phospholipase D	2822	2822	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential mRNA expression of phospholipase_D -LRB- PLD -RRB- isozymes during cAMP-induced differentiation in C6 glioma cells .
9145335	0	PLD	181,184	phospholipase_D	164,179	PLD	phospholipase D	2822	2822	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Differential expression of protein kinase C isozymes and small GTP-binding proteins during HL60 cell differentiation by retinoic_acid and cyclic_AMP : relation with phospholipase_D -LRB- PLD -RRB- activation .
9512645	0	PLD	46,49	phospholipase_D	29,44	PLD	phospholipase D	2822	2822	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased mRNA expression of phospholipase_D -LRB- PLD -RRB- isozymes during granulocytic differentiation of HL60 cells .
14653992	0	PLD1	0,4	mTOR	15,19	PLD1	mTOR	5337	21977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1 .
18625302	0	PLD2	20,24	Cdk5	0,4	PLD2	Cdk5	25097(Tax:10116)	140908(Tax:10116)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cdk5 phosphorylates PLD2 to mediate EGF-dependent insulin secretion .
24270883	0	PLD2	102,106	MicroRNA-203	0,12	PLD2	MicroRNA-203	5338	406986	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-203 inhibits the proliferation and invasion of U251 glioblastoma cells by directly targeting PLD2 .
15681471	0	PLEC1	131,136	plectin	117,124	PLEC1	plectin	5339	5339	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Epidermolysis_bullosa simplex associated with pyloric_atresia is a novel clinical subtype caused by mutations in the plectin gene -LRB- PLEC1 -RRB- .
8894687	0	PLEC1	51,56	plectin	37,44	PLEC1	plectin	5339	5339	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Homozygous deletion mutations in the plectin gene -LRB- PLEC1 -RRB- in patients with epidermolysis_bullosa simplex associated with late-onset muscular_dystrophy .
21455028	0	PLEIADE	75,82	MAP65-1	21,28	PLEIADE	MAP65-1	835234(Tax:3702)	835616(Tax:3702)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Arabidopsis_thaliana MAP65-1 and MAP65-2 function redundantly with MAP65-3 / PLEIADE in cytokinesis downstream of MPK4 .
19500298	0	PLEIOTROPIC_RESPONSE_LOCUS_1	53,81	PRL1	83,87	PLEIOTROPIC RESPONSE LOCUS 1	PRL1	827272(Tax:3702)	827272(Tax:3702)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Modulation of O-mediated retrograde signaling by the PLEIOTROPIC_RESPONSE_LOCUS_1 -LRB- PRL1 -RRB- protein , a central integrator of stress and energy signaling .
26537561	0	PLETHORA3	36,45	LEAFY	53,58	PLETHORA3	LEAFY	830915(Tax:3702)	836307(Tax:3702)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	AINTEGUMENTA and AINTEGUMENTA-LIKE6 / PLETHORA3 induce LEAFY expression in response to auxin to promote the onset of flower formation in Arabidopsis .
2588818	0	PLG	13,16	Plasminogen	0,11	PLG	Plasminogen	5340	5340	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Plasminogen -LRB- PLG -RRB- polymorphism in northern Japanese : confirmation of PLG * M6 allele .
12576095	0	PLG	0,3	hnRNP-L	14,21	PLG	hnRNP-L	85253(Tax:10116)	80846(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex : identification by ddPCR .
17030725	0	PLG	81,84	plasminogen	68,79	PLG	plasminogen	5340	5340	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ligneous_conjunctivitis in a Mexican patient with a mutation in the plasminogen -LRB- PLG -RRB- gene .
26360520	0	PLG	114,117	plasminogen	101,112	PLG	plasminogen	403602(Tax:9615)	403602(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen -LRB- PLG -RRB- gene .
8767722	0	PLG	33,36	plasminogen	20,31	PLG	plasminogen	5340	5340	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of plasminogen -LRB- PLG -RRB- polymorphism in the Namibian !
3416655	0	PLI	56,59	alpha_2-plasmin_inhibitor	24,49	PLI	alpha 2-plasmin inhibitor	5345	5345	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human alpha_2-plasmin_inhibitor gene -LRB- PLI -RRB- to chromosome region 18p11 .1 -- q11 .2 by in situ hybridization .
23408028	0	PLIN	16,20	ATGL	31,35	PLIN	ATGL	25629(Tax:10116)	361676(Tax:10116)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Skeletal muscle PLIN proteins , ATGL and CGI-58 , interactions at rest and following stimulated contraction .
15770500	0	PLIN	73,77	perilipin	57,66	PLIN	perilipin	5346	5346	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Intragenic linkage disequilibrium structure of the human perilipin gene -LRB- PLIN -RRB- and haplotype association with increased obesity risk in a multiethnic Asian population .
20842447	0	PLIN2	36,41	perilipin_2	23,34	PLIN2	perilipin 2	397402(Tax:9823)	397402(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	New SNP of the porcine perilipin_2 -LRB- PLIN2 -RRB- gene , association with carcass traits and expression analysis in skeletal muscle .
25086218	0	PLIN5	29,34	Lipocalin-2	0,11	PLIN5	Lipocalin-2	66968(Tax:10090)	16819(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Lipocalin-2 -LRB- LCN2 -RRB- regulates PLIN5 expression and intracellular lipid droplet formation in the liver .
10383133	0	PLK	45,48	polo-like_kinase	27,43	PLK	polo-like kinase	5347	5347	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of polo-like_kinase -LRB- PLK -RRB- expression in squamous_cell_carcinomas of the head and neck .
9053852	0	PLK	45,48	polo-like_kinase	27,43	PLK	polo-like kinase	5347	5347	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of polo-like_kinase -LRB- PLK -RRB- expression in non-small_cell_lung_cancer .
9083047	0	PLK	53,56	polo-like_kinase	35,51	PLK	polo-like kinase	5347	5347	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Cell cycle regulation of the human polo-like_kinase -LRB- PLK -RRB- promoter .
24777477	0	PLK1	18,22	CLIP-170	0,8	PLK1	CLIP-170	5347	6249	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	CLIP-170 recruits PLK1 to kinetochores during early mitosis for chromosome alignment .
24166892	0	PLK1	25,29	DNA-PKcs	0,8	PLK1	DNA-PKcs	5347	5591	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis .
24623308	0	PLK1	23,27	HSP70	0,5	PLK1	HSP70	5347	3308	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	HSP70 colocalizes with PLK1 at the centrosome and disturbs spindle dynamics in cells arrested in mitosis by arsenic_trioxide .
26057687	0	PLK1	31,35	NDR1	14,18	PLK1	NDR1	5347	10397	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis .
15621805	0	PLK1	32,36	Polo-Like_Kinase	14,30	PLK1	Polo-Like Kinase	5347	5347	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Polo-Like_Kinase -LRB- PLK1 -RRB- in non-Hodgkin 's _ lymphomas .
15015605	0	PLK1	20,24	Polo-like_kinase_1	0,18	PLK1	Polo-like kinase 1	5347	5347	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Polo-like_kinase_1 -LRB- PLK1 -RRB- expression is associated with cell proliferative activity and cdc2 expression in malignant_lymphoma_of_the_thyroid .
22000864	0	PLK1	56,60	Polo-like_kinase_1	36,54	PLK1	Polo-like kinase 1	5347	5347	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Clinicopathological significance of Polo-like_kinase_1 -LRB- PLK1 -RRB- expression in human malignant_glioma .
22390279	0	PLK1	20,24	Polo-like_kinase_1	0,18	PLK1	Polo-like kinase 1	5347	5347	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Polo-like_kinase_1 -LRB- PLK1 -RRB- inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells .
21078677	0	PLK1	0,4	mitotic_centromere-associated_kinesin	20,57	PLK1	mitotic centromere-associated kinesin	5347	11004	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	PLK1 phosphorylates mitotic_centromere-associated_kinesin and promotes its depolymerase activity .
22184200	0	PLK1	0,4	pericentrin	24,35	PLK1	pericentrin	5347	5116	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis .
24859762	0	PLK1	75,79	polo-like_kinase_1	55,73	PLK1	polo-like kinase 1	5347	5347	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Aromatic diacylhydrazine derivatives as a new class of polo-like_kinase_1 -LRB- PLK1 -RRB- inhibitors .
10874315	0	PLOD	53,57	lysyl_hydroxylase_1	27,46	PLOD	lysyl hydroxylase 1	5351	5351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of the lysyl_hydroxylase_1 gene -LRB- PLOD -RRB- in six unrelated patients with Ehlers-Danlos_syndrome_type_VI : prenatal exclusion of this disorder in one family .
12881513	0	PLOD2	18,23	telopeptide_lysyl_hydroxylase	27,56	PLOD2	telopeptide lysyl hydroxylase	5352	5352	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of PLOD2 as telopeptide_lysyl_hydroxylase , an important enzyme in fibrosis .
7528357	0	PLP	75,78	CD4	20,23	PLP	CD4	18823(Tax:10090)	12504(Tax:10090)	Gene	Gene	peptide|compound|START_ENTITY T|nmod|peptide T|nsubj|specificity specificity|nmod|+ +|compound|END_ENTITY	Fine specificity of CD4 + T cell responses to the dominant encephalitogenic PLP 139-151 peptide in SJL/J mice .
7543908	0	PLP	70,73	CD4	91,94	PLP	CD4	5354	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Differential recognition of peptide analogs by naive verses activated PLP 139-151-specific CD4 + T cells .
11733139	0	PLP	88,91	phospholemman-like_protein	60,86	PLP	phospholemman-like protein	19227(Tax:10090)	19227(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of a novel member of the ATP1G1/PLM/MAT8 family , phospholemman-like_protein -LRB- PLP -RRB- gene , in the developmental process of mouse cerebellum .
10441741	0	PLP	55,58	proteolipid_protein	34,53	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular analysis of the porcine proteolipid_protein -LRB- PLP -RRB- gene .
10826694	0	PLP	81,84	proteolipid_protein	60,79	PLP	proteolipid protein	281410(Tax:9913)	281410(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structural analysis and transcript processing of the bovine proteolipid_protein -LRB- PLP -RRB- gene .
1376553	0	PLP	50,53	proteolipid_protein	29,48	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	New variant in exon 3 of the proteolipid_protein -LRB- PLP -RRB- gene in a family with Pelizaeus-Merzbacher_disease .
1378839	0	PLP	77,80	proteolipid_protein	56,75	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of cis-regulatory elements in the myelin proteolipid_protein -LRB- PLP -RRB- gene .
1707231	0	PLP	43,46	proteolipid_protein	22,41	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new mutation in the proteolipid_protein -LRB- PLP -RRB- gene in a German family with Pelizaeus-Merzbacher_disease .
1719156	0	PLP	45,48	proteolipid_protein	24,43	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Induction of the myelin proteolipid_protein -LRB- PLP -RRB- gene in C6 glioblastoma cells : functional analysis of the PLP promotor .
7541731	0	PLP	85,88	proteolipid_protein	64,83	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pelizaeus-Merzbacher_disease : a point mutation in exon 6 of the proteolipid_protein -LRB- PLP -RRB- gene .
7705847	0	PLP	46,49	proteolipid_protein	25,44	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	MvaI polymorphism in the proteolipid_protein -LRB- PLP -RRB- gene .
9747038	0	PLP	97,100	proteolipid_protein	76,95	PLP	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Connatal Pelizaeus-Merzbacher_disease : a missense mutation in exon 4 of the proteolipid_protein -LRB- PLP -RRB- gene .
11180600	0	PLP1	47,51	proteolipid_protein	26,45	PLP1	proteolipid protein	5354	5354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new polymorphism in the proteolipid_protein -LRB- PLP1 -RRB- gene and its use for carrier detection of PLP1 gene duplication in Pelizaeus-Merzbacher_disease .
26287415	0	PLP2	95,99	MiR-664	8,15	PLP2	MiR-664	5355	100302234	Gene	Gene	Proliferation|nmod|START_ENTITY Enhances|dobj|Proliferation Enhances|nsubj|Loss Loss|nmod|Expression Expression|compound|END_ENTITY	Loss of MiR-664 Expression Enhances Cutaneous Malignant Melanoma Proliferation by Upregulating PLP2 .
24604726	0	PLP2	18,22	TPD52	42,47	PLP2	TPD52	5355	7163	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening .
25735976	0	PLP2	29,33	miR-664	0,7	PLP2	miR-664	5355	100302234	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell_acute_lymphoblastic_leukaemia .
7759865	0	PLSTIRE	44,51	cdk6	88,92	PLSTIRE	cdk6	1021	1021	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulation of synthesis and activity of the PLSTIRE protein -LRB- cyclin-dependent_kinase_6 -LRB- cdk6 -RRB- -RRB- , a major cyclin D-associated cdk4 homologue in normal human T lymphocytes .
7759865	0	PLSTIRE	44,51	cyclin-dependent_kinase_6	61,86	PLSTIRE	cyclin-dependent kinase 6	1021	1021	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	Regulation of synthesis and activity of the PLSTIRE protein -LRB- cyclin-dependent_kinase_6 -LRB- cdk6 -RRB- -RRB- , a major cyclin D-associated cdk4 homologue in normal human T lymphocytes .
15795933	0	PLTP	80,84	ApoE	93,97	PLTP	ApoE	5360	348	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Reduced CSF PLTP activity in Alzheimer 's _ disease and other neurologic_diseases ; PLTP induces ApoE secretion in primary human astrocytes in vitro .
24532668	0	PLTP	58,62	Cathepsin_G	0,11	PLTP	Cathepsin G	18830(Tax:10090)	13035(Tax:10090)	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	Cathepsin_G degradation of phospholipid_transfer_protein -LRB- PLTP -RRB- augments pulmonary_inflammation .
15795933	0	PLTP	12,16	PLTP	80,84	PLTP	PLTP	5360	5360	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Reduced CSF PLTP activity in Alzheimer 's _ disease and other neurologic_diseases ; PLTP induces ApoE secretion in primary human astrocytes in vitro .
15795933	0	PLTP	80,84	PLTP	12,16	PLTP	PLTP	5360	5360	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Reduced CSF PLTP activity in Alzheimer 's _ disease and other neurologic_diseases ; PLTP induces ApoE secretion in primary human astrocytes in vitro .
21782857	0	PLTP	0,4	STAT3	15,20	PLTP	STAT3	5360	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PLTP regulates STAT3 and NFkB in differentiated THP1 cells and human monocyte-derived macrophages .
21782857	0	PLTP	0,4	THP1	48,52	PLTP	THP1	5360	2736	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|compound|END_ENTITY	PLTP regulates STAT3 and NFkB in differentiated THP1 cells and human monocyte-derived macrophages .
11254896	0	PLTP	45,49	phospholipid_transfer_protein	14,43	PLTP	phospholipid transfer protein	5360	5360	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	The impact of phospholipid_transfer_protein -LRB- PLTP -RRB- on HDL metabolism .
11566452	0	PLTP	50,54	phospholipid_transfer_protein	19,48	PLTP	phospholipid transfer protein	5360	5360	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of plasma phospholipid_transfer_protein -LRB- PLTP -RRB- in HDL remodeling in acute-phase patients .
17437182	0	PLTP	98,102	phospholipid_transfer_protein	24,53	PLTP	phospholipid transfer protein	18830(Tax:10090)	18830(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY expression|dep|effects expression|nmod|END_ENTITY	Inducible expression of phospholipid_transfer_protein -LRB- PLTP -RRB- in transgenic_mice : acute effects of PLTP on lipoprotein metabolism .
24532668	0	PLTP	58,62	phospholipid_transfer_protein	27,56	PLTP	phospholipid transfer protein	18830(Tax:10090)	18830(Tax:10090)	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Cathepsin_G degradation of phospholipid_transfer_protein -LRB- PLTP -RRB- augments pulmonary_inflammation .
25710294	0	PLTP	47,51	plasma_phospholipid_protein	18,45	PLTP	plasma phospholipid protein	5360	5360	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Elevated baseline plasma_phospholipid_protein -LRB- PLTP -RRB- levels are an independent predictor of long-term all-cause mortality in patients with diabetes_mellitus and known or suspected coronary_artery_disease .
27037800	0	PLURIPETALA	0,11	SCN1	68,72	PLURIPETALA	SCN1	825107(Tax:3702)	819979(Tax:3702)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	PLURIPETALA mediates ROP2 localization and stability in parallel to SCN1 but synergistically with TIP1 in root hairs .
23063469	0	PLVAP	52,57	plasmalemma_vesicle-associated_protein	12,50	PLVAP	plasmalemma vesicle-associated protein	84094(Tax:10090)	84094(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of plasmalemma_vesicle-associated_protein -LRB- PLVAP -RRB- in endothelial cells of Schlemm 's canal and ocular capillaries .
20038602	0	PLZF	14,18	CD4	20,23	PLZF	CD4	7704	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Generation of PLZF + CD4 + T cells via MHC class II-dependent thymocyte-thymocyte interaction is a physiological process in humans .
23776174	0	PLZF	54,58	CD4	67,70	PLZF	CD4	235320(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	A transgenic TCR directs the development of IL-4 + and PLZF + innate CD4 T cells .
12130541	0	PLZF	17,21	EOR-1	11,16	PLZF	EOR-1	7704	177249(Tax:6239)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	C. _ elegans EOR-1 / PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component .
15467736	0	PLZF	98,102	HDAC4	0,5	PLZF	HDAC4	7704	9759	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	HDAC4 mediates transcriptional repression by the acute_promyelocytic_leukaemia-associated protein PLZF .
16637071	0	PLZF	0,4	Pbx1	15,19	PLZF	Pbx1	7704	5087	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate_cancer proliferation .
7623123	0	PLZF	68,72	Promyelocyte_Leukemia_Zinc_Finger	33,66	PLZF	Promyelocyte Leukemia Zinc Finger	235320(Tax:10090)	235320(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Developmental analysis of murine Promyelocyte_Leukemia_Zinc_Finger -LRB- PLZF -RRB- gene expression : implications for the neuromeric model of the forebrain organization .
14527952	0	PLZF	60,64	promyelocytic_leukemia_zinc_finger	16,50	PLZF	promyelocytic leukemia zinc finger	7704	7704	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Modification of promyelocytic_leukemia_zinc_finger protein -LRB- PLZF -RRB- by SUMO-1 conjugation regulates its transcriptional repressor activity .
24821727	0	PLZF	44,48	promyelocytic_leukemia_zinc_finger	8,42	PLZF	promyelocytic leukemia zinc finger	235320(Tax:10090)	235320(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of promyelocytic_leukemia_zinc_finger -LRB- PLZF -RRB- in cell proliferation and cyclin-dependent kinase inhibitor 1A -LRB- p21WAF/CDKN1A -RRB- gene repression .
26285765	0	PMAT	74,78	Plasma_Membrane_Monoamine_Transporter	35,72	PMAT	Plasma Membrane Monoamine Transporter	222962	222962	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Potent and Selective Inhibition of Plasma_Membrane_Monoamine_Transporter -LRB- PMAT -RRB- by HIV Protease Inhibitors .
25802735	0	PMAT	130,134	SLC29A4	83,90	PMAT	SLC29A4	222962	222962	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Autism_spectrum_disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma_membrane_monoamine_transporter -LRB- PMAT -RRB- gene .
25802735	0	PMAT	130,134	plasma_membrane_monoamine_transporter	91,128	PMAT	plasma membrane monoamine transporter	222962	222962	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Autism_spectrum_disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma_membrane_monoamine_transporter -LRB- PMAT -RRB- gene .
14555210	0	PMCA	88,92	plasma_membrane_calcium_ATPase	56,86	PMCA	plasma membrane calcium ATPase	491	491	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Basic_fibroblast_growth_factor -LRB- bFGF -RRB- regulation of the plasma_membrane_calcium_ATPase -LRB- PMCA -RRB- as part of an anti-apoptotic mechanism of action .
25472266	0	PMCA1	69,74	NCKX3	76,81	PMCA1	NCKX3	67972(Tax:10090)	94249(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	PMCA1	69,74	TRPV5	55,60	PMCA1	TRPV5	67972(Tax:10090)	194352(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	PMCA1	69,74	TRPV6	62,67	PMCA1	TRPV6	67972(Tax:10090)	64177(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
26729871	0	PMCA2	0,5	HER2	16,20	PMCA2	HER2	491	2064	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nummod|END_ENTITY	PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast_cancer .
25798335	0	PMCA4	0,5	ATP2B4	7,13	PMCA4	ATP2B4	491	493	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	PMCA4 -LRB- ATP2B4 -RRB- mutation in familial_spastic_paraplegia causes delay in intracellular calcium extrusion .
26729804	0	PMCA4	42,47	IL-2	58,62	PMCA4	IL-2	493	3558	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling .
1572663	0	PMCH	40,44	Pro-melanin-concentrating_hormone	0,33	PMCH	Pro-melanin-concentrating hormone	5367	5367	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pro-melanin-concentrating_hormone gene -LRB- PMCH -RRB- is localized on human chromosome 12q and rat chromosome 7 .
26377365	0	PME-1	38,43	Protein_phosphatase_methylesterase-1	0,36	PME-1	Protein phosphatase methylesterase-1	51400	51400	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Protein_phosphatase_methylesterase-1 -LRB- PME-1 -RRB- expression predicts a favorable clinical outcome in colorectal_cancer .
24928782	0	PME-1	0,5	phosphatase_2A	24,38	PME-1	phosphatase 2A	51400	5524	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	PME-1 modulates protein phosphatase_2A activity to promote the malignant phenotype of endometrial_cancer cells .
24525737	0	PML	48,51	ABCB5	66,71	PML	ABCB5	18854(Tax:10090)	77706(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	The helicase HAGE prevents interferon-a-induced PML expression in ABCB5 + malignant_melanoma-initiating cells by promoting the expression of SOCS1 .
15060166	0	PML	14,17	Bach2	86,91	PML	Bach2	5371	60468	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2 .
18246126	0	PML	0,3	CK1	38,41	PML	CK1	5371	122011	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	PML enhances the regulation of p53 by CK1 in response to DNA damage .
15195100	0	PML	0,3	Mdm2	44,48	PML	Mdm2	5371	4193	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	PML regulates p53 stability by sequestering Mdm2 to the nucleolus .
15735755	0	PML	0,3	Myc	19,22	PML	Myc	5371	4609	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PML interacts with Myc , and Myc target gene expression is altered in PML-null fibroblasts .
22274616	0	PML	0,3	PER2	14,18	PML	PER2	5371	8864	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nummod|END_ENTITY	PML regulates PER2 nuclear localization and circadian function .
22406621	0	PML	56,59	PIAS1	19,24	PML	PIAS1	5371	8554	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA .
18474224	0	PML	76,79	SENP1	88,93	PML	SENP1	5371	29843	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction .
17360386	0	PML	24,27	SUMO-1	39,45	PML	SUMO-1	5371	7341	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid_arthritis synovial fibroblasts .
12384561	0	PML	0,3	beta-catenin	24,36	PML	beta-catenin	5371	1499	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	PML is a target gene of beta-catenin and plakoglobin , and coactivates beta-catenin-mediated transcription .
15194430	0	PML	22,25	c-Myb	0,5	PML	c-Myb	5371	4602	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	c-Myb associates with PML in nuclear bodies in hematopoietic cells .
12907596	0	PML	0,3	homeodomain-interacting_protein_kinase_2	20,60	PML	homeodomain-interacting protein kinase 2	5371	28996	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	PML is required for homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- - mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains .
23440206	0	PML	0,3	mammalian_target_of_rapamycin	40,69	PML	mammalian target of rapamycin	5371	2475	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	PML mediates glioblastoma resistance to mammalian_target_of_rapamycin -LRB- mTOR -RRB- - targeted therapies .
21215282	0	PML	38,41	promyelocytic_leukemia	14,36	PML	promyelocytic leukemia	5371	5371	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Regulation of promyelocytic_leukemia -LRB- PML -RRB- protein levels and cell morphology by bovine_herpesvirus_1 infected cell protein 0 -LRB- bICP0 -RRB- and mutant bICP0 proteins that do not localize to the nucleus .
15383670	0	PML	89,92	promyelocytic_leukemia_protein	57,87	PML	promyelocytic leukemia protein	5371	5371	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Establishment of papillomavirus_infection is enhanced by promyelocytic_leukemia_protein -LRB- PML -RRB- expression .
10429369	0	PMM2	86,90	phosphomannomutase_2	64,84	PMM2	phosphomannomutase 2	5373	5373	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An AciI polymorphism in the 3 ' untranslated region of the human phosphomannomutase_2 -LRB- PMM2 -RRB- gene .
9887379	0	PMM2	46,50	phosphomannomutase_2	24,44	PMM2	phosphomannomutase 2	5373	5373	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detailed mapping of the phosphomannomutase_2 -LRB- PMM2 -RRB- gene and mutation detection enable improved analysis for Scandinavian CDG type I families .
1961179	0	PMNE	39,43	leukocyte_elastase	19,37	PMNE	leukocyte elastase	1991	1991	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	-LSB- Polymorphonuclear leukocyte_elastase -LRB- PMNE -RRB- levels in surgical patients with postoperative_infections -RSB- .
2788801	0	PMNE	39,43	leukocyte_elastase	19,37	PMNE	leukocyte elastase	1991	1991	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Polymorphonuclear leukocyte_elastase -LRB- PMNE -RRB- levels in sepsis ; the effect of PMNE on multiple_organ_failure -LRB- MOF -RRB- -RSB- .
9608630	0	PMNE	94,98	leukocyte_elastase	74,92	PMNE	leukocyte elastase	1991	1991	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Convulsions in hemodialysis -LRB- HD -RRB- patients with elevated polymorphonuclear leukocyte_elastase -LRB- PMNE -RRB- levels .
10733530	0	PMP-22	70,76	gas3	77,81	PMP-22	gas3	5376	5376	Gene	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	PERP , an apoptosis-associated target of p53 , is a novel member of the PMP-22 / gas3 family .
8583222	0	PMP-22	75,81	peripheral_myelin_protein-22	45,73	PMP-22	peripheral myelin protein-22	5376	5376	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion in chromosome 17p11 .2 including the peripheral_myelin_protein-22 -LRB- PMP-22 -RRB- gene in hereditary_neuropathy with liability_to_pressure_palsies .
24321297	0	PMP22	14,19	G3BP1	28,33	PMP22	G3BP1	5376	10146	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Regulation of PMP22 mRNA by G3BP1 affects cell proliferation in breast_cancer cells .
20122990	0	PMP22	44,49	Interleukin-6	0,13	PMP22	Interleukin-6	24660(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-6 upregulates the expression of PMP22 in cultured rat Schwann cells via a JAK2-dependent pathway .
12056842	0	PMP22	77,82	peripheral_myelin_protein_22	47,75	PMP22	peripheral myelin protein 22	18858(Tax:10090)	18858(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the regulatory region of the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- gene that directs temporal and spatial expression in development and regeneration of peripheral nerves .
14664827	0	PMP22	55,60	peripheral_myelin_protein_22	25,53	PMP22	peripheral myelin protein 22	5376	5376	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Distinct elements of the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- promoter regulate expression in Schwann cells and sensory neurons .
26458320	0	PMP22	45,50	peripheral_myelin_protein_22	15,43	PMP22	peripheral myelin protein 22	5376	5376	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Suppression of peripheral_myelin_protein_22 -LRB- PMP22 -RRB- expression by miR29 inhibits the progression of lung_cancer .
8275092	0	PMP22	93,98	peripheral_myelin_protein_22	63,91	PMP22	peripheral myelin protein 22	5376	5376	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dejerine-Sottas_syndrome associated with point mutation in the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- gene .
9040744	0	PMP22	60,65	peripheral_myelin_protein_22	30,58	PMP22	peripheral myelin protein 22	5376	5376	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel point mutation in the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- gene associated with Charcot-Marie-Tooth_disease_type_1A .
21533463	0	PMP22	38,43	peripheral_myelin_protein_22_kDa	4,36	PMP22	peripheral myelin protein 22 kDa	5376	5376	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The peripheral_myelin_protein_22_kDa -LRB- PMP22 -RRB- gene is amplified in cell lines derived from glioma and osteogenic_sarcoma .
8043297	0	PMP35	68,73	peroxisome_assembly_factor-1	38,66	PMP35	peroxisome assembly factor-1	5828	5828	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Structure and expression of mammalian peroxisome_assembly_factor-1 -LRB- PMP35 -RRB- genes .
19035338	0	PMesogenin1_and_2	0,17	Xtbx6	50,55	PMesogenin1 and 2	Xtbx6	100216477(Tax:8355)	394428(Tax:8355)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	PMesogenin1_and_2 function directly downstream of Xtbx6 in Xenopus somitogenesis and myogenesis .
25138159	0	PN-1	88,92	protease_nexin-1	70,86	PN-1	protease nexin-1	5270	5270	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease_nexin-1 -LRB- PN-1 -RRB- inhibition .
26695908	0	PNKP	47,51	CCND1	36,41	PNKP	CCND1	11284	595	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Expression of Cyclin_d1 protein and CCND1 PNKP genes in peripheral blood mononuclear cells in clean up worker of Chornobyl accident with different state of immune system .
1783385	0	PNLIP	44,49	pancreatic_lipase	20,37	PNLIP	pancreatic lipase	5406	5406	Gene	Gene	Assignment|appos|START_ENTITY Assignment|nmod|gene gene|compound|END_ENTITY	Assignment of human pancreatic_lipase gene -LRB- PNLIP -RRB- to chromosome 10q24-q26 .
11378842	0	PNMT	40,44	Phenylethanolamine_N-methyltransferase	0,38	PNMT	Phenylethanolamine N-methyltransferase	5409	5409	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- gene and early-onset Alzheimer_disease .
1303174	0	PNMT	78,82	phenylethanolamine_N-methyltransferase	38,76	PNMT	phenylethanolamine N-methyltransferase	5409	5409	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Genetic linkage of the human gene for phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- , the adrenaline-synthesizing enzyme , to DNA markers on chromosome 17q21-q22 .
1358447	0	PNMT	91,95	phenylethanolamine_N-methyltransferase	51,89	PNMT	phenylethanolamine N-methyltransferase	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Glucocorticoids stimulate transcription of the rat phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- gene in vivo and in vitro .
17175506	0	PNMT	93,97	phenylethanolamine_N-methyltransferase	53,91	PNMT	phenylethanolamine N-methyltransferase	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Modulation by 6-hydroxydopamine of expression of the phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- gene in the rat heart during immobilization stress .
2816488	0	PNMT	54,58	phenylethanolamine_N-methyltransferase	14,52	PNMT	phenylethanolamine N-methyltransferase	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Regulation of phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- mRNA in the rat adrenal medulla by corticosterone .
3440206	0	PNMT	66,70	phenylethanolamine_N-methyltransferase	26,64	PNMT	phenylethanolamine N-methyltransferase	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Glucocorticoid effects on phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- in explants of embryonic_rat_medulla_oblongata .
6381173	0	PNMT	69,73	phenylethanolamine_N-methyltransferase	29,67	PNMT	phenylethanolamine N-methyltransferase	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Glucocorticoid regulation of phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- in organ culture of superior cervical ganglia .
8367022	0	PNMT	66,70	phenylethanolamine_N-methyltransferase	26,64	PNMT	phenylethanolamine N-methyltransferase	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Cold-induced increases in phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- mRNA are mediated by non-cholinergic mechanisms in the rat adrenal gland .
22681853	0	PNP	32,35	p-nitrophenol	17,30	PNP	p-nitrophenol	4860	4860	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Branching of the p-nitrophenol -LRB- PNP -RRB- degradation pathway in burkholderia sp .
3120506	0	PNP	72,75	purine_nucleoside_phosphorylase	39,70	PNP	purine nucleoside phosphorylase	4860	4860	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	8-Amino-9-substituted_guanines : potent purine_nucleoside_phosphorylase -LRB- PNP -RRB- inhibitors .
8931706	0	PNP	101,104	purine_nucleoside_phosphorylase	68,99	PNP	purine nucleoside phosphorylase	4860	4860	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two novel missense and frameshift mutations in exons 5 and 6 of the purine_nucleoside_phosphorylase -LRB- PNP -RRB- gene in a severe_combined_immunodeficiency -LRB- SCID -RRB- patient .
23734760	0	PNPLA-3	81,88	patatin-like_phospholipase_domain-containing_protein-3	25,79	PNPLA-3	patatin-like phospholipase domain-containing protein-3	80339	80339	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the patatin-like_phospholipase_domain-containing_protein-3 -LRB- PNPLA-3 -RRB- gene in Asian Indians with nonalcoholic_fatty_liver_disease .
24002947	0	PNPLA2	37,43	adipose_triglyceride_lipase	8,35	PNPLA2	adipose triglyceride lipase	66853(Tax:10090)	66853(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of adipose_triglyceride_lipase -LRB- PNPLA2 -RRB- in protection from hepatic_inflammation in mouse models of steatohepatitis and endotoxemia .
20480242	0	PNPLA2	92,98	porcine_adipose_triglyceride_lipase	55,90	PNPLA2	porcine adipose triglyceride lipase	57104	57104	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization and association analysis of porcine_adipose_triglyceride_lipase -LRB- PNPLA2 -RRB- gene .
26347999	0	PNPLA3	0,6	XBP1	77,81	PNPLA3	XBP1	116939(Tax:10090)	22433(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	PNPLA3 is involved in hepatic fatty_acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice .
26347999	0	PNPLA3	0,6	XBP1	77,81	PNPLA3	XBP1	116939(Tax:10090)	22433(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	PNPLA3 is involved in hepatic fatty_acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice .
21525193	0	PNPLA3	21,27	adiponutrin	29,40	PNPLA3	adiponutrin	80339	80339	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic variation in PNPLA3 -LRB- adiponutrin -RRB- confers sensitivity to weight loss-induced decrease in liver fat in humans .
20803499	0	PNPLA3	59,65	patatin-like_phospholipase_3	24,52	PNPLA3	patatin-like phospholipase 3	80339	80339	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common variant in the patatin-like_phospholipase_3 gene -LRB- PNPLA3 -RRB- is associated with fatty_liver_disease in obese children and adolescents .
11071390	0	PNR	55,58	photoreceptor_cell-specific_nuclear_receptor	4,48	PNR	photoreceptor cell-specific nuclear receptor	10002	10002	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The photoreceptor_cell-specific_nuclear_receptor gene -LRB- PNR -RRB- accounts for retinitis_pigmentosa in the Crypto-Jews from Portugal -LRB- Marranos -RRB- , survivors from the Spanish Inquisition .
14651967	0	PNRC2	18,23	ERRgamma	99,107	PNRC2	ERRgamma	55629	2104	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma .
25775514	0	PNRC2	39,44	Glucocorticoid_receptor	0,23	PNRC2	Glucocorticoid receptor	55629	2908	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Glucocorticoid_receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation .
19293638	0	PNUTS	42,47	Langerhans_cell_protein_1	0,25	PNUTS	Langerhans cell protein 1	5514	3936	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Langerhans_cell_protein_1 -LRB- LCP1 -RRB- binds to PNUTS in the nucleus : implications for this complex in transcriptional regulation .
12270115	0	PNUTS	0,5	PP1	79,82	PNUTS	PP1	5514	5464	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	PNUTS -LRB- phosphatase_nuclear_targeting_subunit -RRB- inhibits retinoblastoma-directed PP1 activity .
23117887	0	PNUTS	0,5	PTEN	52,56	PNUTS	PTEN	5514	5728	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	PNUTS functions as a proto-oncogene by sequestering PTEN .
24080581	0	POD	30,33	peroxidase	18,28	POD	peroxidase	543959(Tax:4081)	543959(Tax:4081)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Fast detection of peroxidase -LRB- POD -RRB- activity in tomato leaves which infected with Botrytis_cinerea using hyperspectral imaging .
15327992	0	POD-1	25,30	Coronin_7	0,9	POD-1	Coronin 7	79585	79585	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Coronin_7 , the mammalian POD-1 homologue , localizes to the Golgi apparatus .
23313103	0	POD-1	0,5	SF-1	45,49	POD-1	SF-1	6943	7536	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	POD-1 binding to the E-box sequence inhibits SF-1 and StAR expression in human adrenocortical_tumor cells .
26421867	0	POD-1	0,5	SF-1	46,50	POD-1	SF-1	252856(Tax:10116)	117855(Tax:10116)	Gene	Gene	START_ENTITY|appos|reduces reduces|dobj|END_ENTITY	POD-1 / Tcf21 overexpression reduces endogenous SF-1 and StAR expression in rat adrenal cells .
18818395	0	PODXL	22,27	CD49f	49,54	PODXL	CD49f	27205(Tax:10090)	16403(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The CD34-like protein PODXL and alpha6-integrin -LRB- CD49f -RRB- identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice .
26864383	0	PODXL	56,61	podocalyxin-like	38,54	PODXL	podocalyxin-like	192181(Tax:10116)	192181(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Discovery of a frameshift mutation in podocalyxin-like -LRB- PODXL -RRB- gene , coding for a neural_adhesion_molecule , as causal for autosomal-recessive_juvenile_Parkinsonism .
17977532	0	POEM	20,24	TGF-beta	0,8	POEM	TGF-beta	114249(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	TGF-beta suppresses POEM expression through ERK1/2 and JNK in osteoblasts .
23684010	0	POFUT1	13,19	protein_O-fucosyltransferase_1	30,60	POFUT1	protein O-fucosyltransferase 1	403029(Tax:7955)	403029(Tax:7955)	Gene	Gene	Mutations|nmod|START_ENTITY Mutations|amod|END_ENTITY	Mutations in POFUT1 , encoding protein_O-fucosyltransferase_1 , cause generalized Dowling-Degos_disease .
24387993	0	POGLUT1	13,20	protein_O-glucosyltransferase_1	31,62	POGLUT1	protein O-glucosyltransferase 1	56983	56983	Gene	Gene	Mutations|nmod|START_ENTITY Mutations|amod|END_ENTITY	Mutations in POGLUT1 , encoding protein_O-glucosyltransferase_1 , cause autosomal-dominant Dowling-Degos_disease .
25561897	0	POLB	66,70	DNA_polymerase_beta	45,64	POLB	DNA polymerase beta	5423	5423	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Clinical significance of a point mutation in DNA_polymerase_beta -LRB- POLB -RRB- gene in gastric_cancer .
25131834	0	POLD1	62,67	polymerase_delta_1	42,60	POLD1	polymerase delta 1	5424	5424	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel mutation in the polymerase_delta_1 -LRB- POLD1 -RRB- gene in a lipodystrophic patient affected by mandibular_hypoplasia , deafness , progeroid_features _ -LRB- MDPL -RRB- _ syndrome .
26607151	0	POLG	90,94	Polymerase_Gamma	72,88	POLG	Polymerase Gamma	5428	5428	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	Pure Progressive Ataxia_and_Palatal_Tremor -LRB- PAPT -RRB- Associated with a New Polymerase_Gamma -LRB- POLG -RRB- Mutation .
14688158	0	POLG	70,74	polymerase_gamma	47,63	POLG	polymerase gamma	5428	5428	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Frequent polymorphism of the mitochondrial DNA polymerase_gamma gene -LRB- POLG -RRB- in patients with normal spermiograms and unexplained subfertility .
18316366	0	POLG	53,57	polymerase_gamma	35,51	POLG	polymerase gamma	5428	5428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	CAG repeat length variation in the polymerase_gamma -LRB- POLG -RRB- gene : effect on semen quality .
17420318	0	POLG1	57,62	polymerase_gamma-1	37,55	POLG1	polymerase gamma-1	5428	5428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation of the linker region of the polymerase_gamma-1 -LRB- POLG1 -RRB- gene associated with progressive external ophthalmoplegia and Parkinsonism .
17043312	0	POMC	63,67	Brg1	8,12	POMC	Brg1	5443	6597	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing_disease .
2829145	0	POMC	27,31	CRF	0,3	POMC	CRF	18976(Tax:10090)	12918(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	CRF and cAMP regulation of POMC gene expression in corticotrophic_tumor cells .
15833364	0	POMC	15,19	CRH	0,3	POMC	CRH	5443	1392	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	CRH stimulates POMC activity and corticosterone production in dermal fibroblasts .
26563310	0	POMC	25,29	Erythropoietin	0,14	POMC	Erythropoietin	18976(Tax:10090)	13856(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response .
25510553	0	POMC	42,46	FoxO1	0,5	POMC	FoxO1	5443	2308	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3 .
25014196	0	POMC	35,39	Kalrn	15,20	POMC	Kalrn	18976(Tax:10090)	545156(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning .
7514797	0	POMC	22,26	Pro-opiomelanocortin	0,20	POMC	Pro-opiomelanocortin	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pro-opiomelanocortin -LRB- POMC -RRB- gene expression , as identified by in situ hybridization , in purified populations of interstitial macrophages and Leydig cells of the adult rat testis .
25510553	0	POMC	42,46	STAT3	97,102	POMC	STAT3	5443	6774	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nmod|interaction interaction|nmod|END_ENTITY	FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3 .
26563310	0	POMC	25,29	STAT3	45,50	POMC	STAT3	18976(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response .
19759305	0	POMC	29,33	Stat3	9,14	POMC	Stat3	18976(Tax:10090)	20848(Tax:10090)	Gene	Gene	neurons|compound|START_ENTITY activation|nmod|neurons activation|amod|END_ENTITY	Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity .
8094652	0	POMC	92,96	corticotrophin-releasing_factor	11,42	POMC	corticotrophin-releasing factor	18976(Tax:10090)	12917(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotrophin-releasing_factor and arginine-vasopressin on proopiomelanocortin -LRB- POMC -RRB- mRNA levels , release and storage of adrenocorticotrophin from mouse anterior pituitary cells .
21074524	0	POMC	65,69	neurogenin_3	30,42	POMC	neurogenin 3	18976(Tax:10090)	11925(Tax:10090)	Gene	Gene	development|nmod|START_ENTITY END_ENTITY|nmod|development	Differential requirements for neurogenin_3 in the development of POMC and NPY neurons in the hypothalamus .
10395956	0	POMC	76,80	pro-opiomelanocortin	54,74	POMC	pro-opiomelanocortin	422011(Tax:9031)	422011(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and characterization of the chicken pro-opiomelanocortin -LRB- POMC -RRB- gene .
11578531	0	POMC	44,48	pro-opiomelanocortin	22,42	POMC	pro-opiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Ablation of pituitary pro-opiomelanocortin -LRB- POMC -RRB- cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model .
11596869	0	POMC	34,38	pro-opiomelanocortin	12,32	POMC	pro-opiomelanocortin	5443	5443	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ontogeny of pro-opiomelanocortin -LRB- POMC -RRB- gene expression and translated products adrenocorticotrophin -LRB- ACTH -RRB- and alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- in the ovine fetal pituitary gland .
12032760	0	POMC	47,51	pro-opiomelanocortin	25,45	POMC	pro-opiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence analysis of the pro-opiomelanocortin -LRB- POMC -RRB- gene in obese/diabetic Japanese .
12165561	0	POMC	93,97	pro-opiomelanocortin	71,91	POMC	pro-opiomelanocortin	5443	5443	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin -LRB- POMC -RRB- increases susceptibility to early-onset obesity through a novel molecular mechanism .
15864412	0	POMC	104,108	pro-opiomelanocortin	77,97	POMC	pro-opiomelanocortin	5443	5443	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene -LRB- POMC -RRB- with low bone_mineral_density in adult women .
21187100	0	POMC	63,67	pro-opiomelanocortin	41,61	POMC	pro-opiomelanocortin	422011(Tax:9031)	422011(Tax:9031)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Feather follicles express two classes of pro-opiomelanocortin -LRB- POMC -RRB- mRNA using alternative promoters in chickens .
23430746	0	POMC	117,121	pro-opiomelanocortin	95,115	POMC	pro-opiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MicroRNA 375 mediates the signaling pathway of corticotropin-releasing_factor -LRB- CRF -RRB- regulating pro-opiomelanocortin -LRB- POMC -RRB- expression by targeting mitogen-activated_protein_kinase_8 .
24094067	0	POMC	54,58	pro-opiomelanocortin	32,52	POMC	pro-opiomelanocortin	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Down-regulation of hypothalamic pro-opiomelanocortin -LRB- POMC -RRB- expression after weaning is associated with hyperphagia-induced obesity in JCR rats overexpressing neuropeptide_Y .
25377161	0	POMC	45,49	pro-opiomelanocortin	23,43	POMC	pro-opiomelanocortin	5443	5443	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Positive expression of pro-opiomelanocortin -LRB- POMC -RRB- is a novel independent poor prognostic marker in surgically resected non-small_cell_lung_cancer .
2542089	0	POMC	36,40	pro-opiomelanocortin	14,34	POMC	pro-opiomelanocortin	281416(Tax:9913)	281416(Tax:9913)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of pro-opiomelanocortin -LRB- POMC -RRB- by a vaccinia_virus transient expression system and in vitro processing of the expressed prohormone by POMC-converting enzyme .
2698828	0	POMC	54,58	pro-opiomelanocortin	32,52	POMC	pro-opiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tissue-specific activity of the pro-opiomelanocortin -LRB- POMC -RRB- gene and repression by glucocorticoids .
2998878	0	POMC	43,47	pro-opiomelanocortin	21,41	POMC	pro-opiomelanocortin	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the rat pro-opiomelanocortin -LRB- POMC -RRB- gene .
7829983	0	POMC	58,62	pro-opiomelanocortin	36,56	POMC	pro-opiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	ANF -LRB- 1-28 -RRB- is a potent suppressor of pro-opiomelanocortin -LRB- POMC -RRB- mRNA but a weak inhibitor of beta EP-LI release from AtT-20 cells .
7958386	0	POMC	57,61	pro-opiomelanocortin	35,55	POMC	pro-opiomelanocortin	5443	5443	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Presence of the same transcript of pro-opiomelanocortin -LRB- POMC -RRB- genes in the porcine anterior and intermediate pituitary lobes .
9786167	0	POMC	36,40	pro-opiomelanocortin	14,34	POMC	pro-opiomelanocortin	5443	5443	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pro-opiomelanocortin -LRB- POMC -RRB- in the cerebral_ganglion and ovary of a protochordate .
10487685	0	POMC	100,104	proopiomelanocortin	74,93	POMC	proopiomelanocortin	5443	5443	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene , POMC .
11244459	0	POMC	48,52	proopiomelanocortin	27,46	POMC	proopiomelanocortin	5443	5443	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular screening of the proopiomelanocortin -LRB- POMC -RRB- gene in Italian obese children : report of three new mutations .
17764572	0	POMC	33,37	proopiomelanocortin	12,31	POMC	proopiomelanocortin	5443	5443	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of proopiomelanocortin -LRB- POMC -RRB- neurones in feeding behaviour .
18688808	0	POMC	33,37	proopiomelanocortin	12,31	POMC	proopiomelanocortin	5443	5443	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of proopiomelanocortin -LRB- POMC -RRB- in sequentially dependent self-injurious behavior .
19036902	0	POMC	54,58	proopiomelanocortin	33,52	POMC	proopiomelanocortin	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Liver_X_receptor-alpha regulates proopiomelanocortin -LRB- POMC -RRB- gene transcription in the pituitary .
22570972	0	POMC	141,145	proopiomelanocortin	120,139	POMC	proopiomelanocortin	5443	5443	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A case of early-onset obesity , hypocortisolism , and skin pigmentation problem due to a novel homozygous mutation in the proopiomelanocortin -LRB- POMC -RRB- gene in an Indian boy .
23218956	0	POMC	48,52	proopiomelanocortin	27,46	POMC	proopiomelanocortin	5443	5443	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of proopiomelanocortin -LRB- POMC -RRB- transcriptional variants in human skin cells .
2527570	0	POMC	37,41	proopiomelanocortin	16,35	POMC	proopiomelanocortin	396863(Tax:9823)	396863(Tax:9823)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of proopiomelanocortin -LRB- POMC -RRB- immunoreactive neurons in the forebrain of the pig .
2545484	0	POMC	63,67	proopiomelanocortin	42,61	POMC	proopiomelanocortin	5443	5443	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cyclic_AMP-responsive region of the human proopiomelanocortin -LRB- POMC -RRB- gene .
2550299	0	POMC	62,66	proopiomelanocortin	41,60	POMC	proopiomelanocortin	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Effect of ethane_dimethane_sulphonate on proopiomelanocortin -LRB- POMC -RRB- mRNA and POMC-derived peptides in the rat testis .
26753719	0	POMC	109,113	proopiomelanocortin	83,102	POMC	proopiomelanocortin	5443	5443	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations among child_abuse , mental health , and epigenetic modifications in the proopiomelanocortin gene -LRB- POMC -RRB- : A study with children in Tanzania .
8003951	0	POMC	25,29	proopiomelanocortin	4,23	POMC	proopiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The proopiomelanocortin -LRB- POMC -RRB- gene expression of AtT20 mouse pituitary cells is dependent on cell culture conditions .
8094652	0	POMC	92,96	proopiomelanocortin	71,90	POMC	proopiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotrophin-releasing_factor and arginine-vasopressin on proopiomelanocortin -LRB- POMC -RRB- mRNA levels , release and storage of adrenocorticotrophin from mouse anterior pituitary cells .
8413862	0	POMC	42,46	proopiomelanocortin	21,40	POMC	proopiomelanocortin	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Opioid regulation of proopiomelanocortin -LRB- POMC -RRB- gene expression in the rat brain as studied by in situ hybridization .
8536378	0	POMC	45,49	proopiomelanocortin	24,43	POMC	proopiomelanocortin	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Increased expression of proopiomelanocortin -LRB- POMC -RRB- mRNA in adrenal glands of mice undergoing graft-versus-host_disease -LRB- GVHD -RRB- : association with persistent elevated plasma corticosterone levels .
8781560	0	POMC	47,51	proopiomelanocortin	26,45	POMC	proopiomelanocortin	5443	5443	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and release of proopiomelanocortin -LRB- POMC -RRB- derived peptides by human melanocytes and keratinocytes in culture : regulation by ultraviolet B .
10926487	0	POMP	62,66	Ump1	47,51	POMP	Ump1	51371	51371	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7 -LRB- beta_5i -RRB- incorporation into 20 S proteasomes .
10366449	0	POMT1	74,79	rotated_abdomen	52,67	POMT1	rotated abdomen	39297(Tax:7227)	39297(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of a human homolog of the Drosophila rotated_abdomen gene -LRB- POMT1 -RRB- encoding a putative protein O-mannosyl-transferase , and assignment to human chromosome 9q34 .1 .
17533519	0	PON	25,28	paraoxonase	12,23	PON	paraoxonase	5444	5444	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of paraoxonase -LRB- PON -RRB- enzyme in the extent and severity of the coronary_artery_disease in type-2 diabetic patients .
20458968	0	PON-1	30,35	paraoxonase	17,28	PON-1	paraoxonase	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Polymorphism of paraoxonase -LRB- PON-1 -RRB- gene in Slavonic part of Kharkiv population -RSB- .
25487823	0	PON-2	107,112	paraoxonase_1	45,58	PON-2	paraoxonase 1	5445	5444	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|END_ENTITY	Measurement of activity and concentration of paraoxonase_1 -LRB- PON-1 -RRB- in seminal plasma and identification of PON-2 in the sperm of boar ejaculates .
11472729	0	PON1	22,26	Paraoxonase	0,11	PON1	Paraoxonase	5444	5444	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Paraoxonase producing PON1 gene M/L55 polymorphism is related to autopsy-verified artery-wall atherosclerosis .
17704557	0	PON1	13,17	Paraoxonase	0,11	PON1	Paraoxonase	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Paraoxonase -LRB- PON1 -RRB- activity in north west Indian Punjabis with coronary_artery_disease _ type_2_diabetes_mellitus .
24700021	0	PON1	13,17	Paraoxonase	0,11	PON1	Paraoxonase	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Paraoxonase -LRB- PON1 -RRB- activity in patients with subclinical thoracic aortic atherosclerosis .
9170151	0	PON1	13,17	Paraoxonase	0,11	PON1	Paraoxonase	18979(Tax:10090)	18979(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Paraoxonase -LRB- PON1 -RRB- gene in mice : sequencing , chromosomal localization and developmental expression .
17032132	0	PON1	15,19	Paraoxonase-1	0,13	PON1	Paraoxonase-1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Paraoxonase-1 -LRB- PON1 -RRB- activity , but not PON1 -LRB- Q192R -RRB- phenotype , is a predictor of coronary_artery_disease in a middle-aged Serbian population .
23438848	0	PON1	15,19	Paraoxonase-1	0,13	PON1	Paraoxonase-1	5444	5444	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Paraoxonase-1 -LRB- PON1 -RRB- status in pancreatic_cancer : relation to clinical parameters .
18423402	0	PON1	15,19	Paraoxonase_1	0,13	PON1	Paraoxonase 1	5444	5444	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- status in gastroesophageal_malignancies and associated paraneoplastic syndromes - connection with inflammation .
19071155	0	PON1	15,19	Paraoxonase_1	0,13	PON1	Paraoxonase 1	5444	5444	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- status and substrate hydrolysis .
19783251	0	PON1	15,19	Paraoxonase_1	0,13	PON1	Paraoxonase 1	5444	5444	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- expression in hepatocytes is upregulated by pomegranate polyphenols : a role for PPAR-gamma pathway .
20348046	0	PON1	16,20	Paraoxonase_1	1,14	PON1	Paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Paraoxonase_1 -LRB- PON1 -RRB- activity and lipid parameters in Tunisian smokers -RSB- .
20390392	0	PON1	40,44	Paraoxonase_1	25,38	PON1	Paraoxonase 1	5444	5444	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Genetic Polymorphisms of Paraoxonase_1 -LRB- PON1 -RRB- Gene : Association Between L55M or Q192R with Breast_Cancer Risk and Clinico-Pathological Parameters .
20532959	0	PON1	36,40	Paraoxonase_1	21,34	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Relationship between Paraoxonase_1 -LRB- PON1 -RRB- gene polymorphisms and susceptibility of stroke : a meta-analysis .
24589953	0	PON1	38,42	Paraoxonase_1	23,36	PON1	Paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The predictive role of Paraoxonase_1 -LRB- PON1 -RRB- activity on survival in patients with metastatic and nonmetastatic gastric_cancer .
25734763	0	PON1	68,72	Paraoxonase_1	53,66	PON1	Paraoxonase 1	5444	5444	Gene	Gene	Status|appos|START_ENTITY Status|compound|END_ENTITY	Determination of the Genotype and Phenotype of Serum Paraoxonase_1 -LRB- PON1 -RRB- Status in a Group of Agricultural and Nonagricultural Workers in the Coquimbo Region , Chile .
10421480	0	PON1	25,29	paraoxonase	12,23	PON1	paraoxonase	5444	5444	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of paraoxonase -LRB- PON1 -RRB- in the detoxication of organophosphates and its human polymorphism .
10634137	0	PON1	30,34	paraoxonase	17,28	PON1	paraoxonase	5444	5444	Gene	Gene	status|appos|START_ENTITY status|compound|END_ENTITY	Determination of paraoxonase -LRB- PON1 -RRB- status requires more than genotyping .
10669651	0	PON1	44,48	paraoxonase	32,43	PON1	paraoxonase	5444	5444	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations .
10856521	0	PON1	52,56	paraoxonase	39,50	PON1	paraoxonase	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism upstream from the human paraoxonase -LRB- PON1 -RRB- gene and its association with PON1 expression .
10894822	0	PON1	50,54	paraoxonase	38,49	PON1	paraoxonase	5444	5444	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|amod|END_ENTITY	MRI cerebral white_matter_lesions and paraoxonase PON1 polymorphisms : three-year follow-up of the austrian_stroke prevention study .
10923642	0	PON1	50,54	paraoxonase	38,49	PON1	paraoxonase	5444	5444	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Promoter polymorphism T -LRB- -107 -RRB- C of the paraoxonase PON1 gene is a risk factor for coronary_heart_disease in type 2 diabetic patients .
12742701	0	PON1	25,29	paraoxonase	12,23	PON1	paraoxonase	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Human serum paraoxonase -LRB- PON1 -RRB- activity in acute organophosphorous insecticide poisoning .
12777966	0	PON1	33,37	paraoxonase	20,31	PON1	paraoxonase	5444	5444	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human paraoxonase -LRB- PON1 -RRB- during development .
15653099	0	PON1	28,32	paraoxonase	15,26	PON1	paraoxonase	5444	5444	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Measurement of paraoxonase -LRB- PON1 -RRB- status as a potential biomarker of susceptibility to organophosphate_toxicity .
15670573	0	PON1	27,31	paraoxonase	14,25	PON1	paraoxonase	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Modulation of paraoxonase -LRB- PON1 -RRB- activity .
15995178	0	PON1	32,36	paraoxonase	19,30	PON1	paraoxonase	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The correlation of paraoxonase -LRB- PON1 -RRB- activity with lipid and lipoprotein levels differs with vascular_disease status .
16112327	0	PON1	21,25	paraoxonase	8,19	PON1	paraoxonase	18979(Tax:10090)	18979(Tax:10090)	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Role of paraoxonase -LRB- PON1 -RRB- status in pesticide sensitivity : genetic and temporal determinants .
17183021	0	PON1	36,40	paraoxonase	23,34	PON1	paraoxonase	5444	5444	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The association of the paraoxonase -LRB- PON1 -RRB- Q192R polymorphism with depression in older women : findings from the British Women 's Heart and Health Study .
19371607	0	PON1	74,78	paraoxonase	61,72	PON1	paraoxonase	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Risk of carotid_atherosclerosis is associated with low serum paraoxonase -LRB- PON1 -RRB- activity among arsenic exposed residents in Southwestern Taiwan .
9443862	0	PON1	44,48	paraoxonase	25,36	PON1	paraoxonase	5444	5444	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	DNA polymorphisms in two paraoxonase genes -LRB- PON1 and PON2 -RRB- are associated with the risk of coronary_heart_disease .
15704252	0	PON1	74,78	paraoxonase-1	59,72	PON1	paraoxonase-1	5444	5444	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 -LRB- PON1 -RRB- protein in humans .
16323636	0	PON1	124,128	paraoxonase-1	109,122	PON1	paraoxonase-1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Effects of oxidative DNA damage induced by polycyclic_aromatic_hydrocarbons and genetic polymorphism of the paraoxonase-1 -LRB- PON1 -RRB- gene on lung_cancer -RSB- .
19750105	0	PON1	62,66	paraoxonase-1	47,60	PON1	paraoxonase-1	5444	5444	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Serum cholinesterase inhibition in relation to paraoxonase-1 -LRB- PON1 -RRB- status among organophosphate-exposed agricultural pesticide handlers .
24905310	0	PON1	53,57	paraoxonase-1	38,51	PON1	paraoxonase-1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effect of calcium channel blockers on paraoxonase-1 -LRB- PON1 -RRB- activity and oxidative stress .
26417268	0	PON1	79,83	paraoxonase-1	64,77	PON1	paraoxonase-1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Arylesterase activity is associated with antioxidant intake and paraoxonase-1 -LRB- PON1 -RRB- gene methylation in metabolic_syndrome patients following an energy restricted diet .
27012115	0	PON1	32,36	paraoxonase-1	17,30	PON1	paraoxonase-1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Tobacco smoking , paraoxonase-1 -LRB- PON1 -RRB- activity and pleiotropic effects of simvastatin treatment in patients with stable coronary_artery_disease -LRB- CAD -RRB- .
11151764	0	PON1	43,47	paraoxonase_1	23,36	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of human paraoxonase_1 gene -LRB- PON1 -RRB- and susceptibility to diabetic_nephropathy in type_I_diabetes_mellitus .
12545199	0	PON1	75,79	paraoxonase_1	60,73	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Species - and substrate-specific stimulation of human plasma paraoxonase_1 -LRB- PON1 -RRB- activity by high chloride concentration .
17136774	0	PON1	56,60	paraoxonase_1	41,54	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Sex-specific QTL effects on variation in paraoxonase_1 -LRB- PON1 -RRB- activity in Mexican Americans .
18349088	0	PON1	31,35	paraoxonase_1	16,29	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relationship of paraoxonase_1 -LRB- PON1 -RRB- gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk .
19347607	0	PON1	106,110	paraoxonase_1	91,104	PON1	paraoxonase 1	100048952(Tax:9823)	100048952(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence identification , chromosomal mapping and tissue specific expression of the porcine paraoxonase_1 -LRB- PON1 -RRB- gene .
20375196	0	PON1	82,86	paraoxonase_1	67,80	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic association between single nucleotide polymorphisms in the paraoxonase_1 -LRB- PON1 -RRB- gene and small-for-gestational-age birth in related and unrelated subjects .
21044882	0	PON1	73,77	paraoxonase_1	58,71	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Human carotid lesion linoleic_acid_hydroperoxide inhibits paraoxonase_1 -LRB- PON1 -RRB- activity via reaction with PON1 free sulfhydryl_cysteine 284 .
21093416	0	PON1	57,61	paraoxonase_1	42,55	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Pharmacological and dietary modulators of paraoxonase_1 -LRB- PON1 -RRB- activity and expression : the hunt goes on .
21229382	0	PON1	62,66	paraoxonase_1	47,60	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of L55M and Q192R polymorphisms in paraoxonase_1 -LRB- PON1 -RRB- gene with breast_cancer risk and their clinical significance .
21655055	0	PON1	63,67	paraoxonase_1	48,61	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of intronic and exonic polymorphisms of paraoxonase_1 -LRB- PON1 -RRB- gene on serum PON1 activity in a Korean population .
21783258	0	PON1	98,102	paraoxonase_1	83,96	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between bipolar_I_disorder and the L55M and Q192R polymorphisms of the paraoxonase_1 -LRB- PON1 -RRB- gene .
22266287	0	PON1	29,33	paraoxonase_1	14,27	PON1	paraoxonase 1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of paraoxonase_1 -LRB- PON1 -RRB- in PCB_126-exposed male Sprague_Dawley_rats .
22956172	0	PON1	41,45	paraoxonase_1	26,39	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulatory regions of the paraoxonase_1 -LRB- PON1 -RRB- gene are associated with neovascular age-related_macular_degeneration -LRB- AMD -RRB- .
23182497	0	PON1	39,43	paraoxonase_1	24,37	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Positive correlation of paraoxonase_1 -LRB- PON1 -RRB- activity with serum insulin level and HOMA-IR in dementia .
23376056	0	PON1	86,90	paraoxonase_1	71,84	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Plasma protein hydroperoxides during aging in humans : correlation with paraoxonase_1 -LRB- PON1 -RRB- arylesterase activity and plasma total thiols .
24143103	0	PON1	29,33	paraoxonase_1	14,27	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Reduced serum paraoxonase_1 -LRB- PON1 -RRB- activity in patients with schizophrenia treated with olanzapine but not quetiapine .
24971380	0	PON1	29,33	paraoxonase_1	14,27	PON1	paraoxonase 1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Age-dependent paraoxonase_1 -LRB- PON1 -RRB- activity and LDL oxidation in Wistar_rats during their entire lifespan .
25395020	0	PON1	21,25	paraoxonase_1	6,19	PON1	paraoxonase 1	475234(Tax:9615)	475234(Tax:9615)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Serum paraoxonase_1 -LRB- PON1 -RRB- activity in acute pancreatitis of dogs .
26021888	0	PON1	104,108	paraoxonase_1	89,102	PON1	paraoxonase 1	523798(Tax:9913)	523798(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of single nucleotide polymorphisms in the promoter region of the bovine paraoxonase_1 -LRB- PON1 -RRB- gene affecting serum enzyme activity in dairy cows .
26021888	0	PON1	104,108	paraoxonase_1	89,102	PON1	paraoxonase 1	523798(Tax:9913)	523798(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of single nucleotide polymorphisms in the promoter region of the bovine paraoxonase_1 -LRB- PON1 -RRB- gene affecting serum enzyme activity in dairy cows .
26123170	0	PON1	23,27	paraoxonase_1	8,21	PON1	paraoxonase 1	5444	5444	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Lowered paraoxonase_1 -LRB- PON1 -RRB- activity is associated with increased cytokine levels in drug na ve first_episode_psychosis .
27022137	0	PON1	47,51	paraoxonase_1	32,45	PON1	paraoxonase 1	5444	5444	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The common variant Q192R at the paraoxonase_1 -LRB- PON1 -RRB- gene and its activity are responsible for a portion of the altered antioxidant status in type_2_diabetes .
9329371	0	PON2	20,24	Paraoxonase-2	0,13	PON2	Paraoxonase-2	5445	5445	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Paraoxonase-2 gene -LRB- PON2 -RRB- G148 variant associated with elevated fasting plasma glucose_in_noninsulin-dependent_diabetes_mellitus .
15544923	0	PON2	15,19	Paraoxonase_2	0,13	PON2	Paraoxonase 2	330260(Tax:10090)	330260(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Paraoxonase_2 -LRB- PON2 -RRB- expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate -LRB- NADPH -RRB- - oxidase-dependent mechanism during monocytes differentiation into macrophages .
16970920	0	PON2	101,105	paraoxonase_2	86,99	PON2	paraoxonase 2	5445	5445	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	A biphasic U-shape effect of cellular oxidative stress on the macrophage anti-oxidant paraoxonase_2 -LRB- PON2 -RRB- enzymatic activity .
17292903	0	PON2	26,30	paraoxonase_2	11,24	PON2	paraoxonase 2	5445	5445	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Macrophage paraoxonase_2 -LRB- PON2 -RRB- expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR_gamma and AP-1 pathway activation .
18020951	0	PON2	26,30	paraoxonase_2	11,24	PON2	paraoxonase 2	5445	5445	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Macrophage paraoxonase_2 -LRB- PON2 -RRB- expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- pathway .
19546579	0	PON2	46,50	paraoxonase_2	31,44	PON2	paraoxonase 2	5445	5445	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of polymorphisms in paraoxonase_2 -LRB- PON2 -RRB- gene and their association with cardiovascular-renal_disease risk in Mexican Americans .
23047827	0	PON2	68,72	paraoxonase_2	53,66	PON2	paraoxonase 2	5445	5445	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Triglyceride accumulation in macrophages upregulates paraoxonase_2 -LRB- PON2 -RRB- expression via ROS-mediated JNK/c-Jun signaling pathway activation .
17900266	0	PON3	40,44	paraoxonase-3	25,38	PON3	paraoxonase-3	5446	5446	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation in the paraoxonase-3 -LRB- PON3 -RRB- gene is associated with serum PON1 activity .
19426787	0	PON3	81,85	paraoxonase_3	66,79	PON3	paraoxonase 3	269823(Tax:10090)	269823(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization and expression analysis of the porcine paraoxonase_3 -LRB- PON3 -RRB- gene .
12618279	0	PON_1	33,38	paraoxonase	2,13	PON 1	paraoxonase	5444	5444	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	A paraoxonase gene polymorphism , PON_1 -LRB- 55 -RRB- , as an independent risk factor for increased carotid intima-media_thickness in middle-aged women .
12369742	0	PON_1	175,180	paraoxonase_1	160,173	PON 1	paraoxonase 1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effect of peroxisome proliferator-activated receptors alpha -LRB- PPARalpha -RRB- agonist , fenofibrate , on lipid peroxidation , total antioxidant capacity , and plasma paraoxonase_1 -LRB- PON_1 -RRB- activity .
22719896	0	POR	77,80	CYP3A4	112,118	POR	CYP3A4	5447	1576	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|activity activity|nmod|END_ENTITY	Influence of various polymorphic variants of cytochrome P450 oxidoreductase -LRB- POR -RRB- on drug metabolic activity of CYP3A4 and CYP2B6 .
23974086	0	POR	21,24	CYP3A4	10,16	POR	CYP3A4	5447	1576	Gene	Gene	*|dep|START_ENTITY *|compound|END_ENTITY	Effect of CYP3A4 * 22 , POR * 28 , and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients .
26104034	0	POR	31,34	CYP3A4	10,16	POR	CYP3A4	5447	1576	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of CYP3A4 * 1G , CYP3A5 * 3 , POR * 28 , and ABCB1 C3435T on the pharmacokinetics of nifedipine in healthy Chinese volunteers .
12702662	0	POS-1	48,53	glp-1	34,39	POS-1	glp-1	179224(Tax:6239)	176286(Tax:6239)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis_elegans .
16698022	0	POSH	0,4	ALG-2	53,58	POSH	ALG-2	36990(Tax:7227)	3355106(Tax:7227)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	POSH , a scaffold protein for JNK signaling , binds to ALG-2 and ALIX in Drosophila .
22128169	0	POSH	126,130	Plenty_of_SH3s	132,146	POSH	Plenty of SH3s	57630	57630	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun_N-terminal_kinase scaffold POSH -LRB- Plenty_of_SH3s -RRB- protein .
17762203	0	POSH2	18,23	c-Jun_N-terminal_kinase	50,73	POSH2	c-Jun N-terminal kinase	307472(Tax:10116)	116554(Tax:10116)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Identification of POSH2 , a novel homologue of the c-Jun_N-terminal_kinase scaffold protein POSH .
26930720	0	POSTN	63,68	p73	0,3	POSTN	p73	10631	7161	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|nsubj|END_ENTITY	p73 promotes glioblastoma cell invasion by directly activating POSTN -LRB- periostin -RRB- expression .
26930720	0	POSTN	63,68	periostin	70,79	POSTN	periostin	10631	10631	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	p73 promotes glioblastoma cell invasion by directly activating POSTN -LRB- periostin -RRB- expression .
15181449	0	POT1	20,24	PTOP	0,4	POT1	PTOP	25913	65057	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PTOP interacts with POT1 and regulates its localization to telomeres .
19651898	0	POT1	0,4	TRF2	22,26	POT1	TRF2	25913	7014	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	POT1 association with TRF2 regulates telomere length .
25822178	0	POU1F1	35,41	PIT-1	28,33	POU1F1	PIT-1	5449	5449	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Dose-Dependent Dual Role of PIT-1 -LRB- POU1F1 -RRB- in Somatolactotroph Cell Proliferation and Apoptosis .
22985730	0	POU4F3	36,42	ATOH1	111,116	POU4F3	ATOH1	5459	474	Gene	Gene	induction|nmod|START_ENTITY enhance|dobj|induction enhance|nmod|END_ENTITY	TFE2 and GATA3 enhance induction of POU4F3 and myosin_VIIa positive cells in nonsensory cochlear epithelium by ATOH1 .
25015561	0	POU4F3	69,75	ATOH1	56,61	POU4F3	ATOH1	5459	474	Gene	Gene	Gene|compound|START_ENTITY END_ENTITY|nmod|Gene	Transcription Factors with Conserved Binding Sites Near ATOH1 on the POU4F3 Gene Enhance the Induction of Cochlear Hair Cells .
22019428	0	POU5F1	20,26	OCT4	28,32	POU5F1	OCT4	5460	5460	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of POU5F1 -LRB- OCT4 -RRB- gene and its promoter in buffalo ESC-like cells identifies multiple transcription start sites and expression of four pseudogenes .
18212089	0	POU5F1	96,102	Oct4	103,107	POU5F1	Oct4	5460	5460	Gene	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	High-throughput biochemical analysis of in vivo location data reveals novel distinct classes of POU5F1 -LRB- Oct4 -RRB- / DNA complexes .
25509123	0	POU5F1	54,60	Oct4	48,52	POU5F1	Oct4	18999(Tax:10090)	18999(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Investigation of transcriptional regulation of Oct4 -LRB- POU5F1 -RRB- gene with distal enhancer -RSB- .
7601453	0	POUF3	53,58	N-Oct_3	39,46	POUF3	N-Oct 3	5454	5454	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation of the human genomic brain-2 / N-Oct_3 gene -LRB- POUF3 -RRB- and assignment to chromosome 6q16 .
14633703	0	PP1	93,96	AKT	135,138	PP1	AKT	5464	207	Gene	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	The heat_shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast_cancer cells .
20729910	0	PP1	67,70	ALDH1L1	0,7	PP1	ALDH1L1	5464	10840	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A .
21189257	0	PP1	0,3	ASPP2	20,25	PP1	ASPP2	5464	7159	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ .
17511879	0	PP1	19,22	BRCA1	28,33	PP1	BRCA1	5464	672	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of PP1 with BRCA1 and analysis of their expression in breast_tumors .
26474901	0	PP1	0,3	Greatwall	16,25	PP1	Greatwall	5464	84930	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	PP1 inactivates Greatwall to release PP2A-B55 from mitotic confinement .
19874272	0	PP1	37,40	IPP5	10,14	PP1	IPP5	5464	151242	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	Effect of IPP5 , a novel inhibitor of PP1 , on apoptosis and the underlying mechanisms involved .
12270115	0	PP1	79,82	PNUTS	0,5	PP1	PNUTS	5464	5514	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	PNUTS -LRB- phosphatase_nuclear_targeting_subunit -RRB- inhibits retinoblastoma-directed PP1 activity .
11113637	0	PP1	206,209	PP1	83,86	PP1	PP1	5464	5464	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A study of the binding requirements of calyculin_A and dephosphonocalyculin_A with PP1 , development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1 .
11113637	0	PP1	83,86	PP1	206,209	PP1	PP1	5464	5464	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A study of the binding requirements of calyculin_A and dephosphonocalyculin_A with PP1 , development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1 .
23718219	0	PP1	11,14	PPP1R42	0,7	PP1	PPP1R42	5540	286187	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	PPP1R42 , a PP1 binding protein , regulates centrosome dynamics in ARPE-19 cells .
12134149	0	PP1	0,3	Sara	10,14	PP1	Sara	49260(Tax:7227)	44263(Tax:7227)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	PP1 binds Sara and negatively regulates Dpp signaling in Drosophila_melanogaster .
15226296	0	PP1	90,93	Spz1	48,52	PP1	Spz1	19047(Tax:10090)	79401(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
15792837	0	PP1	24,27	Src	2,5	PP1	Src	5464	6714	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	A Src family inhibitor -LRB- PP1 -RRB- potentiates tumor-suppressive effect of connexin_32 gene in renal_cancer cells .
16267045	1	PP1	156,159	TGF-beta_receptors_I_and_II	178,205	PP1	TGF-beta receptors I and II	19047(Tax:10090)	21813(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	PP1 directly inhibits TGF-beta_receptors_I_and_II .
19886865	0	PP1	29,32	TLRR	0,4	PP1	TLRR	5464	286187	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TLRR -LRB- lrrc67 -RRB- interacts with PP1 and is associated with a cytoskeletal complex in the testis .
21738792	0	PP1	0,3	TLRR	33,37	PP1	TLRR	19047(Tax:10090)	69312(Tax:10090)	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	PP1 forms an active complex with TLRR -LRB- lrrc67 -RRB- , a putative PP1 regulatory subunit , during the early stages of spermiogenesis in mice .
21738792	0	PP1	59,62	TLRR	33,37	PP1	TLRR	19047(Tax:10090)	69312(Tax:10090)	Gene	Gene	subunit|compound|START_ENTITY END_ENTITY|appos|subunit	PP1 forms an active complex with TLRR -LRB- lrrc67 -RRB- , a putative PP1 regulatory subunit , during the early stages of spermiogenesis in mice .
15226296	0	PP1	90,93	phosphatase-1	75,88	PP1	phosphatase-1	19047(Tax:10090)	19047(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
6318674	0	PP12	47,51	placenta-specific_tissue_protein_12	10,45	PP12	placenta-specific tissue protein 12	3484	3484	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of placenta-specific_tissue_protein_12 -LRB- PP12 -RRB- in serum during normal pregnancy and in patients with trophoblastic_tumour .
2016092	0	PP14	32,36	placental_protein_14	10,30	PP14	placental protein 14	5047	5047	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human placental_protein_14 -LRB- PP14 -RRB- gene is localized on chromosome 9q34 .
2307483	0	PP14	42,46	placental_protein_14	20,40	PP14	placental protein 14	5047	5047	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of human placental_protein_14 -LRB- PP14 -RRB- on the production of interleukin-1 from mitogenically stimulated mononuclear cell cultures .
3991471	0	PP14	42,46	placental_protein_14	20,40	PP14	placental protein 14	5047	5047	Gene	Gene	relationship|appos|START_ENTITY relationship|nmod|END_ENTITY	The relationship of placental_protein_14 -LRB- PP14 -RRB- in the mother and fetus to specific products of the human placenta .
8844133	0	PP14	28,32	placental_protein_14	6,26	PP14	placental protein 14	5047	5047	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum placental_protein_14 -LRB- PP14 -RRB- levels in patients with threatened abortion .
17277363	0	PP1beta	33,40	Jun_N-terminal_kinase	73,94	PP1beta	Jun N-terminal kinase	49260(Tax:7227)	44801(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The nonmuscle myosin phosphatase PP1beta -LRB- flapwing -RRB- negatively regulates Jun_N-terminal_kinase in wing imaginal discs of Drosophila .
15366010	0	PP1beta9C	0,9	Trithorax	25,34	PP1beta9C	Trithorax	44289(Tax:7227)	41737(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PP1beta9C interacts with Trithorax in Drosophila wing development .
12947324	11	PP2	1467,1470	Src	1452,1455	p38	p38	1432	1432	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The Src inhibitor , PP2 , prevented only the LPS-induced earlier phosphorylation after oxidant stress and had no effect on LPS activation of p38 alone .
16949254	0	PP2	131,134	Src	113,116	PP2	Src	4888	6714	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Role of Src in angiopoietin_1-induced capillary morphogenesis of endothelial cells : Effect of chronic hypoxia on Src inhibition by PP2 .
19818709	0	PP2A	36,40	Alpha4	0,6	PP2A	Alpha4	5524	3476	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	Alpha4 is an essential regulator of PP2A phosphatase activity .
20889715	0	PP2A	55,59	Aurora_B	37,45	PP2A	Aurora B	5524	9212	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|Phosphorylation Phosphorylation|nmod|Sgo2 Sgo2|nmod|END_ENTITY	Phosphorylation of mammalian Sgo2 by Aurora_B recruits PP2A and MCAK to centromeres .
25892238	0	PP2A	50,54	Aurora_B	21,29	PP2A	Aurora B	5524	9212	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Shugoshin-1 Balances Aurora_B Kinase Activity via PP2A to Promote Chromosome Bi-orientation .
26906715	0	PP2A	10,14	Aurora_B	26,34	PP2A	Aurora B	5524	9212	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	IK-guided PP2A suppresses Aurora_B activity in the interphase of tumor cells .
17297438	0	PP2A	77,81	B56beta	58,65	PP2A	B56beta	5524	5526	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Negative regulation of Pim-1 protein kinase levels by the B56beta subunit of PP2A .
19339557	0	PP2A	0,4	BMP	15,18	PP2A	BMP	5524	649	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1 .
23789096	0	PP2A	15,19	BUBR1	0,5	PP2A	BUBR1	5524	701	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression .
17632056	0	PP2A	15,19	CIP2A	0,5	PP2A	CIP2A	5524	57650	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	CIP2A inhibits PP2A in human malignancies .
11536041	0	PP2A	137,141	Cdc55	107,112	PP2A	Cdc55	5524	852685(Tax:4932)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Toxicity of human adenovirus E4orf4 protein in Saccharomyces_cerevisiae results from interactions with the Cdc55 regulatory B subunit of PP2A .
11983168	0	PP2A	18,22	Cyclin_G	0,8	PP2A	Cyclin G	5524	900	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Cyclin_G recruits PP2A to dephosphorylate Mdm2 .
24269630	0	PP2A	103,107	Erk1/2	15,21	PP2A	Erk1/2	5524	5595;5594	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	BAFF activates Erk1/2 promoting cell proliferation and survival by Ca2 + - CaMKII-dependent inhibition of PP2A in normal and neoplastic B-lymphoid cells .
18211894	0	PP2A	0,4	FOXO1	45,50	PP2A	FOXO1	5524	2308	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	PP2A regulates the pro-apoptotic activity of FOXO1 .
17666435	0	PP2A	29,33	GSK-3beta	0,9	PP2A	GSK-3beta	5524	2932	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway , and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis .
15525651	0	PP2A	33,37	Galpha12	0,8	PP2A	Galpha12	5524	2768	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Galpha12 directly interacts with PP2A : evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated_protein , _ tau .
15525651	0	PP2A	72,76	Galpha12	0,8	PP2A	Galpha12	5524	2768	Gene	Gene	evidence|nmod|START_ENTITY phosphatase|nsubj|evidence interacts|parataxis|phosphatase interacts|nsubj|END_ENTITY	Galpha12 directly interacts with PP2A : evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated_protein , _ tau .
17303700	0	PP2A	131,135	Galpha12	22,30	PP2A	Galpha12	5524	2768	Gene	Gene	subunit|nmod|START_ENTITY Domains|parataxis|subunit Domains|amod|necessary necessary|nmod|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
17303700	0	PP2A	131,135	Galpha12	92,100	PP2A	Galpha12	5524	2768	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
17303700	0	PP2A	82,86	Galpha12	22,30	PP2A	Galpha12	5524	2768	Gene	Gene	Domains|appos|START_ENTITY Domains|amod|necessary necessary|nmod|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
17303700	0	PP2A	82,86	Galpha12	92,100	PP2A	Galpha12	5524	2768	Gene	Gene	Domains|appos|START_ENTITY Domains|parataxis|subunit subunit|nsubj|END_ENTITY	Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A -LRB- PP2A -RRB- : Is Galpha12 a novel regulatory subunit of PP2A ?
9009195	0	PP2A	42,46	HOX11	0,5	PP2A	HOX11	399328(Tax:8355)	373832(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint .
25645927	0	PP2A	16,20	HSP105	0,6	PP2A	HSP105	5524	10808	Gene	Gene	START_ENTITY|nsubj|Recruits Recruits|compound|END_ENTITY	HSP105 Recruits PP2A to Dephosphorylate b-Catenin .
19286927	0	PP2A	19,23	IL-8	55,59	PP2A	IL-8	5524	3576	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells .
23381670	0	PP2A	27,31	Insulin_Receptor_Substrate_1	46,74	PP2A	Insulin Receptor Substrate 1	5524	3667	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Phosphoprotein_Phosphatase PP2A Regulation of Insulin_Receptor_Substrate_1 and Insulin Metabolic Signaling .
25897893	0	PP2A	37,41	LB100	0,5	PP2A	LB100	5524	1154026(Tax:189518)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	LB100 , a small molecule inhibitor of PP2A with potent chemo - and radio-sensitizing potential .
25897893	0	PP2A	37,41	LB100	0,5	PP2A	LB100	5524	1154026(Tax:189518)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	LB100 , a small molecule inhibitor of PP2A with potent chemo - and radio-sensitizing potential .
19531360	0	PP2A	0,4	PAR-1	47,52	PP2A	PAR-1	5524	145624	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts .
24100351	0	PP2A	20,24	PTPA	39,43	PP2A	PTPA	5524	5524	Gene	Gene	basis|nmod|START_ENTITY activation|nsubj|basis activation|nmod|END_ENTITY	Structural basis of PP2A activation by PTPA , an ATP-dependent activation chaperone .
12135475	0	PP2A	106,110	Pph22p	57,63	PP2A	Pph22p	5524	851339(Tax:4932)	Gene	Gene	different|nmod|START_ENTITY different|nsubj|END_ENTITY	The Saccharomyces_cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A .
24726876	0	PP2A	27,31	RACK1	35,40	PP2A	RACK1	5524	10399	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling .
25892238	0	PP2A	50,54	Shugoshin-1	0,11	PP2A	Shugoshin-1	5524	151648	Gene	Gene	Activity|nmod|START_ENTITY Activity|compound|END_ENTITY	Shugoshin-1 Balances Aurora_B Kinase Activity via PP2A to Promote Chromosome Bi-orientation .
16115815	0	PP2A	50,54	TGF-beta1	32,41	PP2A	TGF-beta1	5524	7040	Gene	Gene	induced|dobj|START_ENTITY END_ENTITY|acl|induced	A-type lamins are essential for TGF-beta1 induced PP2A to dephosphorylate transcription factors .
15383668	0	PP2A	9,13	p53	34,37	PP2A	p53	5524	7157	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|ARF ARF|acl|signaling signaling|nmod|END_ENTITY	Role for PP2A in ARF signaling to p53 .
17245430	0	PP2A	11,15	p53	95,98	PP2A	p53	5524	7157	Gene	Gene	subunit|compound|START_ENTITY mediates|nsubj|subunit mediates|dobj|dephosphorylation dephosphorylation|nmod|END_ENTITY	A specific PP2A regulatory subunit , B56gamma , mediates DNA damage-induced dephosphorylation of p53 at Thr55 .
19139122	0	PP2A	0,4	p53	85,88	PP2A	p53	5524	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|ionizing ionizing|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53 .
20138402	0	PP2A	5,9	p53	21,24	PP2A	p53	5524	7157	Gene	Gene	I|appos|START_ENTITY regulates|nsubj|I regulates|dobj|END_ENTITY	I -LRB- 2 -RRB- -LRB- PP2A -RRB- regulates p53 and Akt correlatively and leads the neurons to abort apoptosis .
20673369	0	PP2A	80,84	p53	52,55	PP2A	p53	5524	7157	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression .
22289577	0	PP2A	0,4	p53	22,25	PP2A	p53	19052(Tax:10090)	22060(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude_mice through PI3K-Akt-MDM2 signaling suppression .
23622513	0	PP2A	16,20	p53	61,64	PP2A	p53	5524	7157	Gene	Gene	links|nsubj|START_ENTITY links|xcomp|glutamine glutamine|nmod|END_ENTITY	The phosphatase PP2A links glutamine to the tumor suppressor p53 .
23634261	0	PP2A	0,4	pRB	40,43	PP2A	pRB	5524	5925	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs : Potential Implications for PP2A Disruption in Cancer .
23634261	0	PP2A	110,114	pRB	40,43	PP2A	pRB	5524	5925	Gene	Gene	Disruption|compound|START_ENTITY Implications|nmod|Disruption Phosphorylation|dep|Implications Phosphorylation|nmod|END_ENTITY	PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs : Potential Implications for PP2A Disruption in Cancer .
25483052	0	PP2A	0,4	pRB	43,46	PP2A	pRB	5524	5925	Gene	Gene	START_ENTITY|dep|switch switch|nmod|proteins proteins|compound|END_ENTITY	PP2A : more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues .
24939844	0	PP2A	38,42	phosphatase_2A	22,36	PP2A	phosphatase 2A	5524	5524	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of protein phosphatase_2A -LRB- PP2A -RRB- prevents Mcl-1 protein dephosphorylation at the Thr-163 / Ser-159 phosphodegron , dramatically reducing expression in Mcl-1-amplified lymphoma cells .
24390425	0	PP2A-B55a	27,36	FBXL16	14,20	PP2A-B55a	FBXL16	51792(Tax:10090)	214931(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	F-box protein FBXL16 binds PP2A-B55a and regulates differentiation of embryonic stem cells along the FLK1 + lineage .
24165892	0	PP2CA	68,73	PYL13	77,82	PP2CA	PYL13	820314(Tax:3702)	827596(Tax:3702)	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13 .
17219434	0	PP2Cdelta	0,9	Trp53	86,91	PP2Cdelta	Trp53	53892(Tax:10090)	22059(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	PP2Cdelta -LRB- Ppm1d , WIP1 -RRB- , an endogenous inhibitor of p38_MAPK , is regulated along with Trp53 and Cdkn2a following p38_MAPK inhibition during mouse preimplantation development .
17219434	0	PP2Cdelta	0,9	p38_MAPK	52,60	PP2Cdelta	p38 MAPK	53892(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	PP2Cdelta -LRB- Ppm1d , WIP1 -RRB- , an endogenous inhibitor of p38_MAPK , is regulated along with Trp53 and Cdkn2a following p38_MAPK inhibition during mouse preimplantation development .
19088085	0	PP4	0,3	Hedgehog	22,30	PP4	Hedgehog	31979(Tax:7227)	42737(Tax:7227)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation .
16238095	0	PP4	24,27	JNK-1	49,54	PP4	JNK-1	5531	5599	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Role of the phosphatase PP4 in the activation of JNK-1 in prostate_carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity .
11689443	0	PP5	63,66	ASK1	32,36	PP5	ASK1	5536	4217	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Negative feedback regulation of ASK1 by protein phosphatase_5 -LRB- PP5 -RRB- in response to oxidative stress .
9405394	0	PP5	33,36	CDC16	52,57	PP5	CDC16	5536	8881	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27 , two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex .
24068474	0	PP5	32,35	PP5	78,81	PP5	PP5	5536	5536	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity .
24068474	0	PP5	78,81	PP5	32,35	PP5	PP5	5536	5536	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Suramin is a novel activator of PP5 and biphasically modulates S100-activated PP5 activity .
6160287	0	PP5	106,109	SP1	61,64	PP5	SP1	7980	6667	Gene	Gene	1-glycoprotein|appos|START_ENTITY 1-glycoprotein|appos|END_ENTITY	Ectopic synthesis of pregnancy specific beta 1-glycoprotein -LRB- SP1 -RRB- and placental specific tissue proteins -LRB- PP5 , PP10 , PP11 , PP12 -RRB- in nontrophoblastic malignant_tumours .
6755403	0	PP5	105,108	SP1	61,64	PP5	SP1	7980	6667	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Immunohistochemical detection of pregnancy-specific protein -LRB- SP1 -RRB- and placenta-specific tissue proteins -LRB- PP5 , PP10 , PP11 and PP12 -RRB- in ovarian_adenocarcinomas .
6972740	0	PP5	128,131	SP1	92,95	PP5	SP1	7980	6667	Gene	Gene	PP8|compound|START_ENTITY 1-glycoprotein|appos|PP8 1-glycoprotein|appos|END_ENTITY	Immunohistochemical location of proteins related to pregnancy-specific beta 1-glycoprotein -LRB- SP1 -RRB- and placental tissue proteins -LRB- PP5 , PP8 , PP9 , PP10 , PP11 , PP12 -RRB- in the afterbirth of Cynomolgus_monkeys -LRB- Macaca_fascicularis -RRB- .
6975467	0	PP5	37,40	SP1	79,82	PP5	SP1	7980	6667	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Detection of placental protein five -LRB- PP5 -RRB- and pregnancy-specific glycoprotein -LRB- SP1 -RRB- in benign and malignant breast_disease .
18253812	0	PP5	57,60	phosphatase_type_5	37,55	PP5	phosphatase type 5	5536	5536	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of serine/threonine protein phosphatase_type_5 -LRB- PP5 -RRB- in the regulation of stress-induced signaling networks and cancer .
6601264	0	PP5	35,38	placental_protein_5	14,33	PP5	placental protein 5	7980	7980	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of placental_protein_5 -LRB- PP5 -RRB- by non-malignant human fibroblasts in culture .
17210807	0	PPA1	58,62	Progranulin	0,11	PPA1	Progranulin	5464	2896	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Progranulin mutations in primary progressive aphasia : the PPA1 and PPA3 families .
19115207	0	PPAR	123,127	A-FABP	0,6	PPAR	A-FABP	5465	2167	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	A-FABP , a candidate progression marker of human transitional cell carcinoma_of_the_bladder , is differentially regulated by PPAR in urothelial_cancer cells .
16860414	0	PPAR	21,25	EMMPRIN	47,54	PPAR	EMMPRIN	5465	682	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Inhibitory effect of PPAR on the expression of EMMPRIN in macrophages and foam cells .
23948478	0	PPAR	26,30	PGC-1a	19,25	PPAR	PGC-1a	25747(Tax:10116)	83516(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	Regulatory role of PGC-1a / PPAR signaling in skeletal muscle metabolic recruitment during cold acclimation .
26481780	0	PPAR	119,123	PPAR	17,21	PPAR	PPAR	5465	5465	Gene	Gene	role|nmod|START_ENTITY expression|dep|role upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Ligand-activated PPAR upregulates a-smooth_muscle_actin expression in human dermal fibroblasts : A potential role for PPAR in wound healing .
26481780	0	PPAR	17,21	PPAR	119,123	PPAR	PPAR	5465	5465	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|dep|role role|nmod|END_ENTITY	Ligand-activated PPAR upregulates a-smooth_muscle_actin expression in human dermal fibroblasts : A potential role for PPAR in wound healing .
24288525	0	PPAR	17,21	PPARD	29,34	PPAR	PPARD	5465	5467	Gene	Gene	Genes|compound|START_ENTITY Genes|dep|END_ENTITY	Polymorphisms in PPAR Genes -LRB- PPARD , PPARG , and PPARGC1A -RRB- and the Risk of Chronic_Kidney_Disease in Japanese : Cross-Sectional Data from the J-MICC Study .
24855517	0	PPAR	52,56	Peroxisome_Proliferator-Activated_Receptor	8,50	PPAR	Peroxisome Proliferator-Activated Receptor	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Peroxisome_Proliferator-Activated_Receptor -LRB- PPAR -RRB- in Embryonic Stem Cell Proliferation .
26219505	0	PPAR	80,84	Peroxisome_Proliferator_Activated_Receptor	36,78	PPAR	Peroxisome Proliferator Activated Receptor	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Triptolide disrupts fatty_acids and Peroxisome_Proliferator_Activated_Receptor -LRB- PPAR -RRB- levels in male mice testes followed by testicular_injury : A GC-MS based metabolomics study .
26219505	0	PPAR	80,84	Peroxisome_Proliferator_Activated_Receptor	36,78	PPAR	Peroxisome Proliferator Activated Receptor	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Triptolide disrupts fatty_acids and Peroxisome_Proliferator_Activated_Receptor -LRB- PPAR -RRB- levels in male mice testes followed by testicular_injury : A GC-MS based metabolomics study .
25924962	0	PPAR	108,112	Peroxisome_Proliferator_Activated_Receptor_Delta	58,106	PPAR	Peroxisome Proliferator Activated Receptor Delta	100053404(Tax:9796)	100053404(Tax:9796)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Molecular Characterization and Expression Analysis of the Peroxisome_Proliferator_Activated_Receptor_Delta -LRB- PPAR -RRB- Gene before and after Exercise in Horse .
15059948	0	PPAR	44,48	Peroxisome_proliferator-activated_receptor	0,42	PPAR	Peroxisome proliferator-activated receptor	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- activation induces tissue-specific effects on fatty_acid uptake and metabolism in vivo -- a study using the novel PPARalpha/gamma agonist tesaglitazar .
21245137	0	PPAR	44,48	Peroxisome_proliferator-activated_receptor	0,42	PPAR	Peroxisome proliferator-activated receptor	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- gene profiling uncovers insulin-like_growth_factor-1 as a PPARalpha target gene in cardioprotection .
27053360	0	PPAR	56,60	SGLT2	84,89	PPAR	SGLT2	19013(Tax:10090)	246787(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Sodium Intake Regulates Glucose Homeostasis through the PPAR / Adiponectin-Mediated SGLT2 Pathway .
9299560	0	PPAR	42,46	UCP-2	17,22	PPAR	UCP-2	19013(Tax:10090)	22228(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells .
26481780	0	PPAR	119,123	a-smooth_muscle_actin	36,57	PPAR	a-smooth muscle actin	5465	58	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Ligand-activated PPAR upregulates a-smooth_muscle_actin expression in human dermal fibroblasts : A potential role for PPAR in wound healing .
26481780	0	PPAR	17,21	a-smooth_muscle_actin	36,57	PPAR	a-smooth muscle actin	5465	58	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Ligand-activated PPAR upregulates a-smooth_muscle_actin expression in human dermal fibroblasts : A potential role for PPAR in wound healing .
22550474	0	PPAR	32,36	hPPAR	74,79	PPAR	hPPAR	5465	5465	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Conditional Expression of Human PPAR and a Dominant Negative Variant of hPPAR In Vivo .
23779049	0	PPAR	0,4	heme_oxygenase_1	18,34	PPAR	heme oxygenase 1	25747(Tax:10116)	24451(Tax:10116)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	PPAR binding to heme_oxygenase_1 promoter prevents angiotensin_II-induced adipocyte_dysfunction in Goldblatt hypertensive rats .
11389700	0	PPAR	58,62	peroxisome-proliferator-activated_receptor	14,56	PPAR	peroxisome-proliferator-activated receptor	5465	5465	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of peroxisome-proliferator-activated_receptor -LRB- PPAR -RRB- alpha by MK886 .
16277686	0	PPAR	67,71	peroxisome-proliferator-activated_receptor	23,65	PPAR	peroxisome-proliferator-activated receptor	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Contrasting effects of peroxisome-proliferator-activated_receptor -LRB- PPAR -RRB- gamma agonists on membrane-associated prostaglandin_E2 synthase-1 in IL-1beta-stimulated rat chondrocytes : evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12 ,14 prostaglandin_J2 .
9702044	0	PPAR	147,151	peroxisome_proliferation-activated_receptor	102,145	PPAR	peroxisome proliferation-activated receptor	5465	5465	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Lipid metabolism related nuclear receptor -- the structure , function , expression and classification of peroxisome_proliferation-activated_receptor -LRB- PPAR -RRB- -RSB- .
10953038	0	PPAR	57,61	peroxisome_proliferator-activated_receptor	13,55	PPAR	peroxisome proliferator-activated receptor	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	proliferation|appos|START_ENTITY proliferation|amod|END_ENTITY	Evidence for peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- alpha-independent peroxisome proliferation : effects of PPARgamma/delta-specific agonists in PPARalpha-null mice .
11095972	0	PPAR	64,68	peroxisome_proliferator-activated_receptor	20,62	PPAR	peroxisome proliferator-activated receptor	5465	5465	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of human peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- subtypes by pioglitazone .
14646253	0	PPAR	64,68	peroxisome_proliferator-activated_receptor	20,62	PPAR	peroxisome proliferator-activated receptor	5465	5465	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of human peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- subtype selectivity of a variety of anti-inflammatory drugs based on a novel assay for PPAR_delta -LRB- beta -RRB- .
17663016	0	PPAR	81,85	peroxisome_proliferator-activated_receptor	37,79	PPAR	peroxisome proliferator-activated receptor	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Urine acidification has no effect on peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- signaling or epidermal_growth_factor -LRB- EGF -RRB- expression in rat urinary bladder urothelium .
17763950	0	PPAR	57,61	peroxisome_proliferator-activated_receptor	13,55	PPAR	peroxisome proliferator-activated receptor	5465	5465	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- gamma Plo12Ala polymorphism as a shared risk marker for both gastric_cancer and impaired_fasting_glucose -LRB- IFG -RRB- in Japanese .
19172665	0	PPAR	133,137	peroxisome_proliferator-activated_receptor	89,131	PPAR	peroxisome proliferator-activated receptor	5465	5465	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Identification of plant extracts with potential antidiabetic properties : effect on human peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- , adipocyte differentiation and insulin-stimulated glucose uptake .
21530275	0	PPAR	161,165	peroxisome_proliferator-activated_receptor	117,159	PPAR	peroxisome proliferator-activated receptor	5465	5465	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Structure-based design , synthesis , and nonalcoholic_steatohepatitis -LRB- NASH -RRB- - preventive effect of phenylpropanoic_acid peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- a-selective agonists .
8651933	0	PPAR	62,66	peroxisome_proliferator-activated_receptor	18,60	PPAR	peroxisome proliferator-activated receptor	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- in the mouse colonic mucosa .
11007963	0	PPAR	57,61	peroxisome_proliferator-activated_receptors	12,55	PPAR	peroxisome proliferator-activated receptors	5465	5465	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the peroxisome_proliferator-activated_receptors -LRB- PPAR -RRB- in atherosclerosis .
24758429	0	PPAR	30,34	peroxisome_proliferator-activated_receptors	36,79	PPAR	peroxisome proliferator-activated receptors	5465	5465	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Enantioselective synthesis of PPAR -LRB- peroxisome_proliferator-activated_receptors -RRB- agonists and antagonists .
14521714	0	PPAR	81,85	peroxisome_proliferator_activated_receptor	37,79	PPAR	peroxisome proliferator activated receptor	5465	5465	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Gamma -LRB- gamma -RRB- tocopherol upregulates peroxisome_proliferator_activated_receptor -LRB- PPAR -RRB- gamma -LRB- gamma -RRB- expression in SW 480 human colon_cancer cell lines .
16912428	0	PPAR	54,58	peroxisome_proliferator_activated_receptor	10,52	PPAR	peroxisome proliferator activated receptor	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of peroxisome_proliferator_activated_receptor -LRB- PPAR -RRB- gamma agonists on prostaglandins cascade in joint cells .
23921352	0	PPAR	95,99	peroxisome_proliferator_activated_receptor	51,93	PPAR	peroxisome proliferator activated receptor	5465	5465	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The effect of embryo presence on the expression of peroxisome_proliferator_activated_receptor -LRB- PPAR -RRB- genes in the porcine reproductive system during periimplantation .
26693220	0	PPAR-a	0,6	Irisin	43,49	PPAR-a	Irisin	5465	252995	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
25614670	0	PPAR-a	59,65	PGC-1a	52,58	PPAR-a	PGC-1a	5465	10891	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1a / PPAR-a Signaling .
26944934	0	PPAR-a	0,6	RANTES	37,43	PPAR-a	RANTES	5465	6352	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased RANTES Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
25614670	0	PPAR-a	59,65	SIRT1	35,40	PPAR-a	SIRT1	5465	23411	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1a / PPAR-a Signaling .
23681751	0	PPAR-a	115,121	peroxisome_proliferator-activated_receptor-a	69,113	PPAR-a	peroxisome proliferator-activated receptor-a	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Dill seed extract improves abnormalities in lipid metabolism through peroxisome_proliferator-activated_receptor-a -LRB- PPAR-a -RRB- activation in diabetic_obese mice .
15521013	0	PPAR-alpha	61,71	CYP1A1	25,31	PPAR-alpha	CYP1A1	5465	1543	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites .
16341933	0	PPAR-alpha	0,10	IL-1beta	71,79	PPAR-alpha	IL-1beta	25747(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	PPAR-alpha expression inversely correlates with inflammatory cytokines IL-1beta and TNF-alpha in aging rats .
19336949	0	PPAR-alpha	52,62	adiponectin_receptor_2	14,36	PPAR-alpha	adiponectin receptor 2	19013(Tax:10090)	68465(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of adiponectin_receptor_2 expression via PPAR-alpha in NIT-1 cells .
16369181	0	PPAR-alpha	69,79	peroxisome_proliferator-activated_receptor-alpha	19,67	PPAR-alpha	peroxisome proliferator-activated receptor-alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	ROLE|appos|START_ENTITY ROLE|nmod|END_ENTITY	ROLE of endogenous peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- ligands in the development of gut ischemia and reperfusion in mice .
16501055	0	PPAR-alpha	66,76	peroxisome_proliferator-activated_receptor-alpha	16,64	PPAR-alpha	peroxisome proliferator-activated receptor-alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- in the regulation of acute inflammation .
19503102	0	PPAR-alpha	54,64	peroxisome_proliferator-activated_receptor-alpha	4,52	PPAR-alpha	peroxisome proliferator-activated receptor-alpha	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- agonist , AVE8134 , attenuates the progression of heart_failure and increases survival in rats .
24751833	0	PPAR-alpha	0,10	vanin-1	35,42	PPAR-alpha	vanin-1	19013(Tax:10090)	22361(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism .
19088437	0	PPAR-gamma	8,18	CD36	40,44	PPAR-gamma	CD36	5468	948	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line .
18615182	0	PPAR-gamma	12,22	COX-2	48,53	PPAR-gamma	COX-2	5468	4513	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of PPAR-gamma and Its Interaction with COX-2 in Pancreatic_Cancer .
19627000	0	PPAR-gamma	20,30	COX-2	32,37	PPAR-gamma	COX-2	5468	4513	Gene	Gene	expressions|nmod|START_ENTITY -LSB-|dobj|expressions -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The expressions of PPAR-gamma , COX-2 in the lesions of patients with condyloma_acuminatum and bowenoid_papulosis -RSB- .
14614508	0	PPAR-gamma	72,82	CREB	0,4	PPAR-gamma	CREB	19016(Tax:10090)	12912(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma .
17074304	0	PPAR-gamma	104,114	CTGF	46,50	PPAR-gamma	CTGF	25664(Tax:10116)	64032(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Rosiglitazone inhibits angiotensin_II-induced CTGF expression in vascular smooth muscle cells - role of PPAR-gamma in vascular fibrosis .
18547997	0	PPAR-gamma	27,37	Klotho	0,6	PPAR-gamma	Klotho	5468	9365	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Klotho is a target gene of PPAR-gamma .
16335797	0	PPAR-gamma	72,82	Leptin	0,6	PPAR-gamma	Leptin	5468	3952	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Leptin down-regulates peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- mRNA levels in primary human monocyte-derived macrophages .
12468449	0	PPAR-gamma	50,60	Peroxisome_proliferator-activated_receptor-gamma	0,48	PPAR-gamma	Peroxisome proliferator-activated receptor-gamma	19016(Tax:10090)	19016(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets .
15758247	0	PPAR-gamma	50,60	Peroxisome_proliferator-activated_receptor_gamma	0,48	PPAR-gamma	Peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- agonist increases plasma adiponectin levels in type 2 diabetic patients with proteinuria .
17601490	0	PPAR-gamma	37,47	SHP	30,33	PPAR-gamma	SHP	5468	8431	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of SHP by PPAR-gamma in liver .
15670761	0	PPAR-gamma	0,10	VEGF	70,74	PPAR-gamma	VEGF	19016(Tax:10090)	22339(Tax:10090)	Gene	Gene	ligands|amod|START_ENTITY up-regulate|nsubj|ligands up-regulate|dobj|release release|amod|END_ENTITY	PPAR-gamma ligands up-regulate basic_fibroblast_growth_factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts .
16904074	0	PPAR-gamma	112,122	VEGF	42,46	PPAR-gamma	VEGF	281993(Tax:9913)	281572(Tax:9913)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma .
17320065	0	PPAR-gamma	0,10	VEGF	45,49	PPAR-gamma	VEGF	25664(Tax:10116)	83785(Tax:10116)	Gene	Gene	agonists|amod|START_ENTITY induce|nsubj|agonists induce|dobj|expression expression|nmod|END_ENTITY	PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts .
11712859	0	PPAR-gamma	61,71	peroxisome_proliferator-activated_receptor-gamma	11,59	PPAR-gamma	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytes .
12609711	0	PPAR-gamma	79,89	peroxisome_proliferator-activated_receptor-gamma	29,77	PPAR-gamma	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- gene and risk of prostate_cancer among men in a large cancer prevention study .
16335797	0	PPAR-gamma	72,82	peroxisome_proliferator-activated_receptor_gamma	22,70	PPAR-gamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Leptin down-regulates peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- mRNA levels in primary human monocyte-derived macrophages .
17877580	0	PPAR-gamma	64,74	peroxisome_proliferator-activated_receptor_gamma	14,62	PPAR-gamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- in canine nasal_carcinomas .
11596673	0	PPAR-gamma2	95,106	peroxisome_proliferator-activated_receptor-gamma2	44,93	PPAR-gamma2	peroxisome proliferator-activated receptor-gamma2	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Studies of the Pro12Ala polymorphism of the peroxisome_proliferator-activated_receptor-gamma2 -LRB- PPAR-gamma2 -RRB- gene in relation to insulin sensitivity among glucose tolerant caucasians .
20133449	0	PPAR-gamma_coactivator-1alpha	0,29	SF-1	96,100	PPAR-gamma coactivator-1alpha	SF-1	83516(Tax:10116)	117855(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	PPAR-gamma_coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1 .
25986483	0	PPAR-y	118,124	Peroxisome_Proliferator-Activated_Receptor_Gamma	68,116	PPAR-y	Peroxisome Proliferator-Activated Receptor Gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A candidate gene study reveals association between a variant of the Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPAR-y -RRB- gene and systemic_sclerosis .
25986483	0	PPAR-y	118,124	Peroxisome_Proliferator-Activated_Receptor_Gamma	68,116	PPAR-y	Peroxisome Proliferator-Activated Receptor Gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A candidate gene study reveals association between a variant of the Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPAR-y -RRB- gene and systemic_sclerosis .
25896411	0	PPAR-y	91,97	Peroxisome_Proliferator_Activated_Receptor-Gamma	41,89	PPAR-y	Peroxisome Proliferator Activated Receptor-Gamma	5468	5468	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Impact of the C1431T Polymorphism of the Peroxisome_Proliferator_Activated_Receptor-Gamma -LRB- PPAR-y -RRB- Gene on Fasted Serum Lipid Levels in Patients with Coronary_Artery_Disease .
17317762	0	PPARA	94,99	peroxisome_proliferator-activated_receptor-alpha	39,87	PPARA	peroxisome proliferator-activated receptor-alpha	5465	5465	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms of the peroxisome_proliferator-activated_receptor-alpha gene -LRB- PPARA -RRB- influence the conversion from impaired_glucose_tolerance_to_type_2_diabetes : the STOP-NIDDM trial .
20087658	0	PPARA	80,85	peroxisome_proliferator-activated_receptor_alpha	25,73	PPARA	peroxisome proliferator-activated receptor alpha	374120(Tax:9031)	374120(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation of the peroxisome_proliferator-activated_receptor_alpha gene -LRB- PPARA -RRB- in chickens bred for different purposes .
18726867	0	PPARA	85,90	peroxisome_proliferator_activated_receptor_alpha	30,78	PPARA	peroxisome proliferator activated receptor alpha	5465	5465	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	The L162V polymorphism of the peroxisome_proliferator_activated_receptor_alpha gene -LRB- PPARA -RRB- is not associated with type 2 diabetes , BMI or body fat composition .
22920733	0	PPARA	126,131	peroxisome_proliferator_activator_receptor-a	75,119	PPARA	peroxisome proliferator activator receptor-a	5465	5465	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation of endocannabinoid system genes suggests association between peroxisome_proliferator_activator_receptor-a gene -LRB- PPARA -RRB- and schizophrenia .
24288525	0	PPARD	29,34	PPAR	17,21	PPARD	PPAR	5467	5465	Gene	Gene	Genes|dep|START_ENTITY Genes|compound|END_ENTITY	Polymorphisms in PPAR Genes -LRB- PPARD , PPARG , and PPARGC1A -RRB- and the Risk of Chronic_Kidney_Disease in Japanese : Cross-Sectional Data from the J-MICC Study .
24118591	0	PPARD	79,84	Peroxisome_Proliferator-Activated_Receptor_Delta	29,77	PPARD	Peroxisome Proliferator-Activated Receptor Delta	5467	5467	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic haplotype within the Peroxisome_Proliferator-Activated_Receptor_Delta -LRB- PPARD -RRB- gene is associated with elite athletic status .
19862325	0	PPARG	0,5	CDKAL1	15,21	PPARG	CDKAL1	5468	54901	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	PPARG , KCNJ11 , CDKAL1 , CDKN2A-CDKN2B , IDE-KIF11-HHEX , IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population .
20424228	0	PPARG	29,34	CDKN2A	67,73	PPARG	CDKN2A	5468	1029	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	PPARG	29,34	HHEX	61,65	PPARG	HHEX	5468	3087	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
19862325	0	PPARG	0,5	KCNJ11	7,13	PPARG	KCNJ11	5468	3767	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	PPARG , KCNJ11 , CDKAL1 , CDKN2A-CDKN2B , IDE-KIF11-HHEX , IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population .
20424228	0	PPARG	29,34	KCNJ11	36,42	PPARG	KCNJ11	5468	3767	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	PPARG	29,34	SLC30A8	52,59	PPARG	SLC30A8	5468	169026	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	PPARG	29,34	TCF7L2	44,50	PPARG	TCF7L2	5468	6934	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
15843495	0	PPARG	62,67	cyclooxygenase_2	31,47	PPARG	cyclooxygenase 2	5468	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of cytokine-induced cyclooxygenase_2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells .
17921408	0	PPARG	76,81	peroxisome_proliferator-activated_receptor-gamma	21,69	PPARG	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ala12 variant of the peroxisome_proliferator-activated_receptor-gamma gene -LRB- PPARG -RRB- is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial_infarction .
19186181	0	PPARG	82,87	peroxisome_proliferator-activated_receptor_gamma	32,80	PPARG	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Colorectal_cancer expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARG , PPARgamma -RRB- is associated with good prognosis .
22803842	0	PPARG	134,139	peroxisome_proliferator-activated_receptor_gamma	84,132	PPARG	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A complicated pregnancy in a patient with lipodystrophic_diabetes attributable to a peroxisome_proliferator-activated_receptor_gamma -LRB- PPARG -RRB- mutation .
25182148	0	PPARG	83,88	peroxisome_proliferator-activated_receptor_gamma	33,81	PPARG	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor_gamma -LRB- PPARG -RRB- gene in relation to obesity and metabolic phenotypes in a Taiwanese population .
19846795	0	PPARG2	96,102	peroxisome_proliferator-activated_receptor-gamma	46,94	PPARG2	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Breast-feeding modulates the influence of the peroxisome_proliferator-activated_receptor-gamma -LRB- PPARG2 -RRB- Pro12Ala polymorphism on adiposity in adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence -LRB- HELENA -RRB- cross-sectional study .
20179158	0	PPARG2	79,85	peroxisome_proliferator-activated_receptor-gamma2	28,77	PPARG2	peroxisome proliferator-activated receptor-gamma2	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The association between the peroxisome_proliferator-activated_receptor-gamma2 -LRB- PPARG2 -RRB- Pro12Ala gene variant and type_2_diabetes_mellitus : a HuGE review and meta-analysis .
12663371	0	PPARG2	92,98	peroxisome_proliferator-activated_receptor_gamma-2	40,90	PPARG2	peroxisome proliferator-activated receptor gamma-2	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alanine for proline substitution in the peroxisome_proliferator-activated_receptor_gamma-2 -LRB- PPARG2 -RRB- gene and the risk of incident myocardial_infarction .
10585775	0	PPARGC1	70,77	peroxisome_proliferator_activated_receptor_gamma_coactivator_1	6,68	PPARGC1	peroxisome proliferator activated receptor gamma coactivator 1	10891	10891	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human peroxisome_proliferator_activated_receptor_gamma_coactivator_1 -LRB- PPARGC1 -RRB- gene : cDNA sequence , genomic organization , chromosomal localization , and tissue expression .
16759305	0	PPARGC1B	93,101	peroxisome_proliferator-activated_receptor_gamma_co-activator_1beta	24,91	PPARGC1B	peroxisome proliferator-activated receptor gamma co-activator 1beta	133522	133522	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Putative association of peroxisome_proliferator-activated_receptor_gamma_co-activator_1beta -LRB- PPARGC1B -RRB- polymorphism with Type_2_diabetes_mellitus .
23353867	0	PPAR_alpha	35,45	KLF6	49,53	PPAR alpha	KLF6	5465	1316	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Post-transcriptional activation of PPAR_alpha by KLF6 in hepatic_steatosis .
10471118	0	PPAR_alpha	66,76	peroxisome_proliferator-activated_receptor_alpha	16,64	PPAR alpha	peroxisome proliferator-activated receptor alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the peroxisome_proliferator-activated_receptor_alpha -LRB- PPAR_alpha -RRB- in the control of cardiac lipid metabolism .
9610365	0	PPAR_alpha	64,74	peroxisome_proliferator-activated_receptor_alpha	14,62	PPAR alpha	peroxisome proliferator-activated receptor alpha	5465	5465	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_alpha -LRB- PPAR_alpha -RRB- in primary cultures of human vascular endothelial cells .
18853997	0	PPAR_alpha	82,92	peroxisome_proliferator_activated_receptor_alpha	32,80	PPAR alpha	peroxisome proliferator activated receptor alpha	5465	5465	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A Val227Ala substitution in the peroxisome_proliferator_activated_receptor_alpha -LRB- PPAR_alpha -RRB- gene associated with non-alcoholic_fatty_liver_disease and decreased waist circumference and waist-to-hip ratio .
15733729	0	PPAR_delta	69,79	peroxisome_proliferator-activated_receptor_delta	19,67	PPAR delta	peroxisome proliferator-activated receptor delta	5467	5467	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Regulatory role of peroxisome_proliferator-activated_receptor_delta -LRB- PPAR_delta -RRB- in muscle metabolism .
19423085	0	PPAR_gamma	0,10	F4/80	34,39	PPAR gamma	F4/80	19016(Tax:10090)	13733(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	PPAR_gamma is highly expressed in F4/80 -LRB- hi -RRB- adipose tissue macrophages and dampens adipose-tissue inflammation .
18444964	0	PPAR_gamma	0,10	MITF	21,25	PPAR gamma	MITF	19016(Tax:10090)	17342(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PPAR_gamma regulates MITF and beta-catenin expression and promotes a differentiated phenotype in mouse melanoma S91 .
17651710	0	PPAR_gamma	44,54	PEDF	0,4	PPAR gamma	PEDF	5468	5176	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	PEDF induces p53-mediated apoptosis through PPAR_gamma signaling in human umbilical vein endothelial cells .
20553736	0	PPAR_gamma	105,115	Pigment_epithelium-derived_factor	0,33	PPAR gamma	Pigment epithelium-derived factor	5468	57104	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	Pigment_epithelium-derived_factor induces interleukin-10 expression in human macrophages by induction of PPAR_gamma .
12044870	0	PPAR_gamma	21,31	TNF-alpha	79,88	PPAR gamma	TNF-alpha	5468	7124	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of PPAR_gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes .
12044870	0	PPAR_gamma	21,31	UCP-1	53,58	PPAR gamma	UCP-1	5468	7350	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Differential role of PPAR_gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes .
16400517	0	PPAR_gamma	0,10	VEGF	21,25	PPAR gamma	VEGF	5468	7422	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	PPAR_gamma represses VEGF expression in human endometrial cells : implications for uterine angiogenesis .
20303941	0	PPAR_gamma	40,50	beta-catenin	14,26	PPAR gamma	beta-catenin	5468	1499	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Repression of beta-catenin signaling by PPAR_gamma ligands .
12475986	0	PPAR_gamma	157,167	early_growth_response-1	111,134	PPAR gamma	early growth response-1	5468	1958	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Troglitazone , a peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR_gamma -RRB- ligand , selectively induces the early_growth_response-1 gene independently of PPAR_gamma .
14534304	1	PPAR_gamma	121,131	peroxisome_proliferator-activated_receptor-gamma	71,119	PPAR gamma	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR_gamma -RRB- agonists and 9-cis-retinoic_acid .
10674402	0	PPAR_gamma	122,132	peroxisome_proliferator-activated_receptor_gamma	72,120	PPAR gamma	peroxisome proliferator-activated receptor gamma	19016(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prolactin enhances CCAAT enhancer-binding protein-beta -LRB- C/EBP _ beta -RRB- and peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR_gamma -RRB- messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells .
12457461	0	PPAR_gamma	91,101	peroxisome_proliferator-activated_receptor_gamma	41,89	PPAR gamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Early stimulation and late inhibition of peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR_gamma -RRB- gene expression by transforming_growth_factor_beta in human aortic smooth muscle cells : role of early_growth-response_factor-1 -LRB- Egr-1 -RRB- , activator_protein_1 -LRB- AP1 -RRB- and Smads .
11409297	0	PPAR_gamma	111,121	peroxisome_proliferator_activated_receptor_gamma	61,109	PPAR gamma	peroxisome proliferator activated receptor gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between the P12A and c1431t polymorphisms in the peroxisome_proliferator_activated_receptor_gamma -LRB- PPAR_gamma -RRB- gene and type 2 diabetes .
21280563	0	PPAR_gamma_co-activator_1_alpha	43,74	PGC-1alpha	76,86	PPAR gamma co-activator 1 alpha	PGC-1alpha	19017(Tax:10090)	19017(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Long-term caloric restriction up-regulates PPAR_gamma_co-activator_1_alpha -LRB- PGC-1alpha -RRB- expression in mice .
27051413	0	PPARa	37,42	AMPK	84,88	PPARa	AMPK	25747(Tax:10116)	78975(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Possible Role of Interaction between PPARa and Cyclophilin_D in Cardioprotection of AMPK against In Vivo_Ischemia-Reperfusion in Rats .
23919842	0	PPARa	34,39	APOE	20,24	PPARa	APOE	5465	348	Gene	Gene	polymorphisms|dep|START_ENTITY polymorphisms|compound|END_ENTITY	Association between APOE , SCARB1 , PPARa polymorphisms and serum lipids in a population of Lithuanian adults .
26556865	0	PPARa	0,5	Bcl2	44,48	PPARa	Bcl2	5465	596	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	PPARa induces cell apoptosis by destructing Bcl2 .
22100307	0	PPARa	37,42	GATA-6	21,27	PPARa	GATA-6	5465	2627	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Transcription factor GATA-6 recruits PPARa to cooperatively activate Glut4 gene expression .
22100809	0	PPARa	44,49	LRH-1_and_SHP	51,64	PPARa	LRH-1 and SHP	5465	2494;8431	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of miR-200c by nuclear receptors PPARa , LRH-1_and_SHP .
22723831	0	PPARa	22,27	MEK1	0,4	PPARa	MEK1	19013(Tax:10090)	26395(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	MEK1 inhibits cardiac PPARa activity by direct interaction and prevents its nuclear localization .
25320343	0	PPARa	67,72	Monocarboxylate_transporters_1_and_4	0,36	PPARa	Monocarboxylate transporters 1 and 4	5465	9122	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Monocarboxylate_transporters_1_and_4 : expression and regulation by PPARa in ovine ruminal epithelial cells .
26116825	0	PPARa	37,42	MuRF1	21,26	PPARa	MuRF1	5465	84676	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The ubiquitin ligase MuRF1 regulates PPARa activity in the heart by enhancing nuclear export via monoubiquitination .
21326871	0	PPARa	71,76	NADPH_oxidase_1	19,34	PPARa	NADPH oxidase 1	19013(Tax:10090)	237038(Tax:10090)	Gene	Gene	mechanism|compound|START_ENTITY blocks|nmod|mechanism blocks|nsubj|END_ENTITY	Targeting vascular NADPH_oxidase_1 blocks tumor angiogenesis through a PPARa mediated mechanism .
20953676	0	PPARa	51,56	NPC1L1	6,12	PPARa	NPC1L1	5465	29881	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Human NPC1L1 expression is positively regulated by PPARa .
25299939	0	PPARa	74,79	OCTN2	60,65	PPARa	OCTN2	281992(Tax:9913)	20520(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the human , porcine and bovine OCTN2 gene by PPARa via a conserved PPRE located in intron 1 .
21286700	0	PPARa	50,55	PGC-1a	92,98	PPARa	PGC-1a	5465	10891	Gene	Gene	Peroxisome_proliferator_activated_receptor-alpha|appos|START_ENTITY gamma|nsubj|Peroxisome_proliferator_activated_receptor-alpha gamma|dobj|regulation regulation|appos|END_ENTITY	Peroxisome_proliferator_activated_receptor-alpha -LRB- PPARa -RRB- and PPAR gamma coactivator-1alpha -LRB- PGC-1a -RRB- regulation of cardiac metabolism in diabetes .
22033933	0	PPARa	46,51	PGC-1a	83,89	PPARa	PGC-1a	5465	10891	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Peroxisome proliferator-activated receptor a -LRB- PPARa -RRB- induces PPARy coactivator 1a -LRB- PGC-1a -RRB- gene expression and contributes to thermogenic activation of brown fat : involvement of PRDM16 .
22168458	0	PPARa	46,51	Peroxisome_proliferator-activated_receptor_a	0,44	PPARa	Peroxisome proliferator-activated receptor a	5465	5465	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_a -LRB- PPARa -RRB- mRNA expression in human hepatocellular_carcinoma tissue and non-cancerous liver tissue .
24845641	0	PPARa	0,5	SDF-1	91,96	PPARa	SDF-1	19013(Tax:10090)	20315(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	PPARa regulates mobilization and homing of endothelial progenitor cells through the HIF-1a / SDF-1 pathway .
26983400	0	PPARa	31,36	SIK2	0,4	PPARa	SIK2	5465	23235	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	SIK2 regulates fasting-induced PPARa activity and ketogenesis through p300 .
22349506	0	PPARa	0,5	hENT1	52,57	PPARa	hENT1	5465	2030	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	PPARa and PPARy regulate the nucleoside transporter hENT1 .
21640707	0	PPARa	60,65	peroxisome_proliferator-activated_receptor-a	14,58	PPARa	peroxisome proliferator-activated receptor-a	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-a -LRB- PPARa -RRB- suppresses postprandial_lipidemia through fatty_acid oxidation in enterocytes .
20654716	0	PPARa	63,68	peroxisome_proliferator-activated_receptor-alpha	13,61	PPARa	peroxisome proliferator-activated receptor-alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Influence of peroxisome_proliferator-activated_receptor-alpha -LRB- PPARa -RRB- activity on adverse effects associated with amiodarone exposure in mice .
22932900	0	PPARa	60,65	peroxisome_proliferator-activated_receptor_a	14,58	PPARa	peroxisome proliferator-activated receptor a	5465	5465	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_a -LRB- PPARa -RRB- suppresses hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- signaling in cancer cells .
17686565	0	PPARalpha	99,108	ABCD2	75,80	PPARalpha	ABCD2	5465	225	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Dehydroepiandrosterone up-regulates the Adrenoleukodystrophy-related gene -LRB- ABCD2 -RRB- independently of PPARalpha in rodents .
15585952	0	PPARalpha	27,36	AhR	49,52	PPARalpha	AhR	25747(Tax:10116)	25690(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY ligand|nmod|regulation ligand|nsubj|function function|nmod|END_ENTITY	Down regulation of hepatic PPARalpha function by AhR ligand .
17963696	0	PPARalpha	0,9	AhR	36,39	PPARalpha	AhR	5465	196	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	PPARalpha transcriptionally induces AhR expression in Caco-2 , but represses AhR pro-inflammatory effects .
17084382	0	PPARalpha	78,87	CD36	53,57	PPARalpha	CD36	5465	948	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cholesteryl_ester hydroperoxides increase macrophage CD36 gene expression via PPARalpha .
15828232	0	PPARalpha	89,98	CLOCK	107,112	PPARalpha	CLOCK	5465	9575	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	-LSB- Hyperlipidemia and peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- -- regulation of the PPARalpha gene by CLOCK : BMAL1 -RSB- .
19823578	0	PPARalpha	55,64	CYP2J2	17,23	PPARalpha	CYP2J2	5465	1573	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo .
17601491	0	PPARalpha	0,9	FGF21	40,45	PPARalpha	FGF21	5465	26291	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PPARalpha is a key regulator of hepatic FGF21 .
18840432	0	PPARalpha	44,53	FGF21	24,29	PPARalpha	FGF21	19013(Tax:10090)	56636(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY induced|nmod|activation induced|nsubjpass|expression expression|nmod|END_ENTITY	Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver .
20197053	0	PPARalpha	49,58	FGF21	8,13	PPARalpha	FGF21	19013(Tax:10090)	56636(Tax:10090)	Gene	Gene	birth|nmod|START_ENTITY induced|nmod|birth induced|nsubjpass|expression expression|compound|END_ENTITY	Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat .
15503648	0	PPARalpha	77,86	HNF-4alpha	45,55	PPARalpha	HNF-4alpha	5465	3172	Gene	Gene	alternative|nmod|START_ENTITY END_ENTITY|nmod|alternative	Hypolipidemia induced by PPARalpha agonists : HNF-4alpha as an alternative to PPARalpha .
17321000	0	PPARalpha	65,74	Interleukin-1_receptor_antagonist	4,37	PPARalpha	Interleukin-1 receptor antagonist	5465	3557	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	The Interleukin-1_receptor_antagonist is a direct target gene of PPARalpha in liver .
19289416	0	PPARalpha	31,40	L-FABP	0,6	PPARalpha	L-FABP	19013(Tax:10090)	14080(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	L-FABP directly interacts with PPARalpha in cultured primary hepatocytes .
16950137	0	PPARalpha	60,69	PGC-1alpha	49,59	PPARalpha	PGC-1alpha	19013(Tax:10090)	19017(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Lipin_1 is an inducible amplifier of the hepatic PGC-1alpha / PPARalpha regulatory pathway .
18848838	0	PPARalpha	108,117	Thioredoxin-1	0,13	PPARalpha	Thioredoxin-1	5465	7295	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Thioredoxin-1 and its natural inhibitor , vitamin_D3_up-regulated_protein_1 , are differentially regulated by PPARalpha in human macrophages .
10873645	0	PPARalpha	85,94	UCP-3	26,31	PPARalpha	UCP-3	25747(Tax:10116)	25708(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPARalpha and PPARgamma ligands .
18455211	0	PPARalpha	0,9	alanine_aminotransferase	46,70	PPARalpha	alanine aminotransferase	5465	2875	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PPARalpha regulates the hepatotoxic biomarker alanine_aminotransferase -LRB- ALT1 -RRB- gene expression in human hepatocytes .
17355223	0	PPARalpha	0,9	bombesin_receptor_subtype_3	33,60	PPARalpha	bombesin receptor subtype 3	5465	680	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	PPARalpha and AP-2alpha regulate bombesin_receptor_subtype_3 expression in ozone-stressed bronchial epithelial cells .
20097691	0	PPARalpha	82,91	brain-derived_neurotropic_factor	135,167	PPARalpha	brain-derived neurotropic factor	19013(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARalpha and FGF21 in mice with hepatic ablation of brain-derived_neurotropic_factor .
19577614	0	PPARalpha	83,92	carnitine-acylcarnitine_translocase	6,41	PPARalpha	carnitine-acylcarnitine translocase	19013(Tax:10090)	57279(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Mouse carnitine-acylcarnitine_translocase -LRB- CACT -RRB- is transcriptionally regulated by PPARalpha and PPARdelta in liver cells .
17550778	0	PPARalpha	52,61	fibroblast_growth_factor_21	8,35	PPARalpha	fibroblast growth factor 21	19013(Tax:10090)	56636(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Hepatic fibroblast_growth_factor_21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states .
21245137	0	PPARalpha	108,117	insulin-like_growth_factor-1	74,102	PPARalpha	insulin-like growth factor-1	19013(Tax:10090)	16000(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- gene profiling uncovers insulin-like_growth_factor-1 as a PPARalpha target gene in cardioprotection .
12740007	0	PPARalpha	77,86	peroxisome_proliferator-activated_receptor-alpha	27,75	PPARalpha	peroxisome proliferator-activated receptor-alpha	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Acute -LRB- 24 h -RRB- activation of peroxisome_proliferator-activated_receptor-alpha -LRB- PPARalpha -RRB- reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets .
15447978	0	PPARalpha	58,67	peroxisome_proliferator-activated_receptor-alpha	8,56	PPARalpha	peroxisome proliferator-activated receptor-alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of peroxisome_proliferator-activated_receptor-alpha -LRB- PPARalpha -RRB- in bezafibrate-induced hepatocarcinogenesis and cholestasis .
11409711	0	PPARalpha	80,89	peroxisome_proliferator-activated_receptor_alpha	30,78	PPARalpha	peroxisome proliferator-activated receptor alpha	5465	5465	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism , L162V , in the peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- gene is associated with lower body mass index in patients with non-insulin-dependent_diabetes_mellitus .
11734553	0	PPARalpha	61,70	peroxisome_proliferator-activated_receptor_alpha	11,59	PPARalpha	peroxisome proliferator-activated receptor alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in the control of cardiac malonyl-CoA levels : reduced fatty_acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA_decarboxylase .
11994294	0	PPARalpha	62,71	peroxisome_proliferator-activated_receptor_alpha	12,60	PPARalpha	peroxisome proliferator-activated receptor alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	WY14 ,643 , a peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- agonist , improves hepatic and muscle_steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F -1 mice .
12580534	0	PPARalpha	75,84	peroxisome_proliferator-activated_receptor_alpha	25,73	PPARalpha	peroxisome proliferator-activated receptor alpha	5465	5465	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Functional activation of peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- by environmental chemicals in relation to their toxicities .
15837165	0	PPARalpha	79,88	peroxisome_proliferator-activated_receptor_alpha	29,77	PPARalpha	peroxisome proliferator-activated receptor alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Reduced LPA expression after peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- activation in LPA-YAC transgenic_mice .
18602970	0	PPARalpha	61,70	peroxisome_proliferator-activated_receptor_alpha	11,59	PPARalpha	peroxisome proliferator-activated receptor alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- agonists on leucine-induced phosphorylation of translational targets in C2C12 cells .
20637823	0	PPARalpha	69,78	peroxisome_proliferator-activated_receptor_alpha	19,67	PPARalpha	peroxisome proliferator-activated receptor alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of prenatal peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- agonism on postnatal development .
15631825	0	PPARalpha	38,47	plasminogen_activator_inhibitor-1	67,100	PPARalpha	plasminogen activator inhibitor-1	5465	5054	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	-LSB- An exploratory study on mechanism of PPARalpha activators-induced plasminogen_activator_inhibitor-1 expression in HepG-2 cells -RSB- .
12419217	0	PPARbeta	22,30	Akt1	83,87	PPARbeta	Akt1	5467	207	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway .
17275789	0	PPARdelta	0,9	PGC-1alpha	40,50	PPARdelta	PGC-1alpha	5467	10891	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	PPARdelta , but not PPARalpha , activates PGC-1alpha gene transcription in muscle .
16337160	0	PPARdelta	50,59	Peroxisome_proliferator-activated_receptor_delta	0,48	PPARdelta	Peroxisome proliferator-activated receptor delta	25682(Tax:10116)	25682(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_delta -LRB- PPARdelta -RRB- activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis .
12465041	0	PPARdelta	23,32	TNFalpha	0,8	PPARdelta	TNFalpha	5467	7124	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells : implications for demyelinating_diseases .
11782441	0	PPARgamma	40,49	C/EBPalpha	0,10	PPARgamma	C/EBPalpha	5468	1050	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	C/EBPalpha induces adipogenesis through PPARgamma : a unified pathway .
9421462	0	PPARgamma	0,9	C/EBPalpha	84,94	PPARgamma	C/EBPalpha	5468	1050	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|GLUT4 GLUT4|nmod|absence absence|nmod|END_ENTITY	PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes .
11972632	0	PPARgamma	50,59	CD36	86,90	PPARgamma	CD36	5468	948	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Peroxisome-proliferator-activated-receptor_gamma -LRB- PPARgamma -RRB- independent induction of CD36 in THP-1 monocytes by retinoic_acid .
17459764	0	PPARgamma	75,84	COX-2	65,70	PPARgamma	COX-2	5468	5743	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	n-3 and n-6 polyunsaturated_fatty_acids induce the expression of COX-2 via PPARgamma activation in human keratinocyte HaCaT cells .
17669705	0	PPARgamma	0,9	COX-2	77,82	PPARgamma	COX-2	25664(Tax:10116)	26198(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|osteogenesis osteogenesis|nmod|down-regulation down-regulation|nmod|expression expression|nmod|END_ENTITY	PPARgamma inhibits osteogenesis via the down-regulation of the expression of COX-2 and iNOS in rats .
9421462	0	PPARgamma	0,9	GLUT4	60,65	PPARgamma	GLUT4	5468	6517	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes .
19951697	0	PPARgamma	76,85	HtrA3	0,5	PPARgamma	HtrA3	5468	94031	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	HtrA3 is regulated by 15-deoxy-Delta12 ,14 - prostaglandin_J2 independently of PPARgamma in clear_cell_renal_cell_carcinomas .
17458857	0	PPARgamma	60,69	IL-13	0,5	PPARgamma	IL-13	5468	3596	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	IL-13 induces expression of CD36 in human monocytes through PPARgamma activation .
20226837	0	PPARgamma	16,25	Leptin	0,6	PPARgamma	Leptin	19016(Tax:10090)	16846(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Leptin inhibits PPARgamma gene expression in hepatic stellate cells in the mouse model of liver_damage .
12947137	0	PPARgamma	34,43	MMP-9	14,19	PPARgamma	MMP-9	5468	4318	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of MMP-9 expression by PPARgamma activators in human bronchial epithelial cells .
19887620	0	PPARgamma	33,42	NHE1	14,18	PPARgamma	NHE1	5468	6548	Gene	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|nummod|END_ENTITY	Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo .
15990085	0	PPARgamma	70,79	PAI-1	49,54	PPARgamma	PAI-1	5468	5054	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation .
16388849	0	PPARgamma	35,44	PAPP-A	14,20	PPARgamma	PAPP-A	5468	5069	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of PAPP-A expression by PPARgamma in human first trimester trophoblast .
12866036	0	PPARgamma	64,73	PGC-1	107,112	PPARgamma	PGC-1	5468	10891	Gene	Gene	peroxisome-proliferator_activated_receptor-gamma|appos|START_ENTITY Expression|nmod|peroxisome-proliferator_activated_receptor-gamma Expression|amod|END_ENTITY	Expression of peroxisome-proliferator_activated_receptor-gamma -LRB- PPARgamma -RRB- and the PPARgamma co-activator , PGC-1 , in human breast_cancer correlates with clinical outcomes .
17089023	0	PPARgamma	15,24	PGC-1	9,14	PPARgamma	PGC-1	5468	10891	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Does the PGC-1 / PPARgamma pathway play a role in Com-1 / p8 mediated cell growth inhibition in prostate_cancer ?
20519122	0	PPARgamma	18,27	PGC1beta	0,8	PPARgamma	PGC1beta	19016(Tax:10090)	170826(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone_loss .
19583951	0	PPARgamma	51,60	PTIP	30,34	PPARgamma	PTIP	19016(Tax:10090)	55982(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis .
16442504	0	PPARgamma	50,59	Peroxisome-proliferator-activated_receptor-gamma	0,48	PPARgamma	Peroxisome-proliferator-activated receptor-gamma	5468	5468	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Peroxisome-proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- activation protects neurons from NMDA excitotoxicity .
12714563	0	PPARgamma	50,59	Peroxisome_proliferator-activated_receptor_gamma	0,48	PPARgamma	Peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression is decreased in pulmonary hypertension and affects endothelial cell growth .
10448095	0	PPARgamma	0,9	STAT1	40,45	PPARgamma	STAT1	5468	6772	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	PPARgamma ligand-dependent induction of STAT1 , STAT5A , and STAT5B during adipogenesis .
18615188	0	PPARgamma	21,30	TGFbeta1	45,53	PPARgamma	TGFbeta1	5468	7040	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	A Novel Mechanism of PPARgamma Regulation of TGFbeta1 : Implication in Cancer Biology .
18655773	0	PPARgamma	14,23	TNF-alpha	36,45	PPARgamma	TNF-alpha	5468	7124	Gene	Gene	Regulation|nmod|START_ENTITY function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of PPARgamma function by TNF-alpha .
15880426	0	PPARgamma	39,48	Th1	0,3	PPARgamma	Th1	5468	51497	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary_biliary_cirrhosis .
20501643	0	PPARgamma	141,150	Wnt7A	127,132	PPARgamma	Wnt7A	5468	7476	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Sprouty-4 inhibits transformed cell growth , migration and invasion , and epithelial-mesenchymal transition , and is regulated by Wnt7A through PPARgamma in non-small cell lung_cancer .
20102333	0	PPARgamma	75,84	acetoacetyl-CoA_synthetase	40,66	PPARgamma	acetoacetyl-CoA synthetase	5468	65985	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the human acetoacetyl-CoA_synthetase gene by PPARgamma .
17848638	0	PPARgamma	0,9	adipose_triglyceride_lipase	20,47	PPARgamma	adipose triglyceride lipase	19016(Tax:10090)	66853(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PPARgamma regulates adipose_triglyceride_lipase in adipocytes in vitro and in vivo .
17030193	0	PPARgamma	22,31	c-Abl	50,55	PPARgamma	c-Abl	5468	25	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells .
10558888	0	PPARgamma	0,9	c-MET	37,42	PPARgamma	c-MET	5468	4233	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	PPARgamma inhibits the expression of c-MET in human gastric_cancer cells through the suppression of Ets .
15610522	0	PPARgamma	77,86	cyclin_D1	22,31	PPARgamma	cyclin D1	19016(Tax:10090)	12443(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Troglitazone inhibits cyclin_D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes .
20650001	0	PPARgamma	61,70	estrogen-receptor	74,91	PPARgamma	estrogen-receptor	5468	2099	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast_cancer cells .
15356214	0	PPARgamma	87,96	inducible_nitric-oxide_synthase	119,150	PPARgamma	inducible nitric-oxide synthase	19016(Tax:10090)	18126(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Peroxisome_proliferation-activated_receptor -LRB- PPAR -RRB- gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible_nitric-oxide_synthase and nitric_oxide .
19383491	0	PPARgamma	0,9	insulin-degrading_enzyme	56,80	PPARgamma	insulin-degrading enzyme	5468	3416	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	PPARgamma transcriptionally regulates the expression of insulin-degrading_enzyme in primary neurons .
10989952	0	PPARgamma	11,20	leptin	90,96	PPARgamma	leptin	5468	3952	Gene	Gene	exon|compound|START_ENTITY CAC|nsubj|exon CAC|parataxis|affect affect|dobj|levels levels|compound|END_ENTITY	The silent PPARgamma exon 6 CAC -LRB- His -RRB- _ -- > _ CAT -LRB- His -RRB- polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany .
15114521	0	PPARgamma	11,20	leptin	53,59	PPARgamma	leptin	25664(Tax:10116)	25608(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY agonists|nsubj|Effects agonists|nmod|levels levels|compound|END_ENTITY	Effects of PPARgamma and PPARalpha agonists on serum leptin levels in diet-induced obese rats .
17909895	0	PPARgamma	54,63	leptin	129,135	PPARgamma	leptin	19016(Tax:10090)	16846(Tax:10090)	Gene	Gene	peroxisome_proliferator_activated_receptor_gamma|appos|START_ENTITY ligand|nsubj|peroxisome_proliferator_activated_receptor_gamma ligand|dobj|levels levels|nmod|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin , adiponectin , and inflammatory cytokines in lean and obese mice .
19385085	0	PPARgamma	56,65	leptin	46,52	PPARgamma	leptin	25664(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY involved|nmod|expression involved|nmod|effect effect|nmod|END_ENTITY	Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro .
20643096	0	PPARgamma	83,92	myocardial_lipid_droplet_protein	27,59	PPARgamma	myocardial lipid droplet protein	19016(Tax:10090)	66968(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	The gene expression of the myocardial_lipid_droplet_protein is highly regulated by PPARgamma in adipocytes differentiated from MEFs or SVCs .
11741533	0	PPARgamma	80,89	p38	51,54	PPARgamma	p38	5468	1432	Gene	Gene	activation|nmod|START_ENTITY kinase|dobj|activation kinase|nsubj|stimulation stimulation|nmod|expenditure expenditure|nmod|MAP MAP|amod|END_ENTITY	Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1 .
18312546	0	PPARgamma	15,24	p38	51,54	PPARgamma	p38	19016(Tax:10090)	26416(Tax:10090)	Gene	Gene	activator|compound|START_ENTITY Effects|nmod|activator pioglitazone|nsubj|Effects pioglitazone|nmod|kinase kinase|amod|END_ENTITY	Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic_lateral_sclerosis .
19478555	0	PPARgamma	110,119	p38	50,53	PPARgamma	p38	5468	1432	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma .
14587029	0	PPARgamma	19,28	p65	86,89	PPARgamma	p65	5468	5970	Gene	Gene	Phosphorylation|nmod|START_ENTITY leads|nsubj|Phosphorylation leads|nmod|END_ENTITY	Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta .
16616945	0	PPARgamma	64,73	peroxisome_proliferator-activated_receptor-gamma	14,62	PPARgamma	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- induces cell death through MAPK-dependent mechanism in osteoblastic cells .
18072811	0	PPARgamma	62,71	peroxisome_proliferator-activated_receptor-gamma	12,60	PPARgamma	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- in Alzheimer 's _ disease : therapeutic implications .
18565023	0	PPARgamma	58,67	peroxisome_proliferator-activated_receptor-gamma	8,56	PPARgamma	peroxisome proliferator-activated receptor-gamma	25664(Tax:10116)	25664(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- during liver_regeneration in rats .
19104705	0	PPARgamma	79,88	peroxisome_proliferator-activated_receptor-gamma	29,77	PPARgamma	peroxisome proliferator-activated receptor-gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- gene in inflammatory_bowel_disease .
11043863	0	PPARgamma	64,73	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in normal human pancreatic islet cells .
11205925	0	PPARgamma	83,92	peroxisome_proliferator-activated_receptor_gamma	33,81	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Novel expression and function of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in human neuroblastoma cells .
12527853	1	PPARgamma	98,107	peroxisome_proliferator-activated_receptor_gamma	48,96	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- -RSB- .
12912973	0	PPARgamma	69,78	peroxisome_proliferator-activated_receptor_gamma	19,67	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	HER2 regulation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression and sensitivity of breast_cancer cells to PPARgamma ligand therapy .
14675851	0	PPARgamma	75,84	peroxisome_proliferator-activated_receptor_gamma	25,73	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Quantitative analysis of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression in arteries and hearts of patients with ischaemic or dilated_cardiomyopathy .
15899154	0	PPARgamma	91,100	peroxisome_proliferator-activated_receptor_gamma	41,89	PPARgamma	peroxisome proliferator-activated receptor gamma	25664(Tax:10116)	25664(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	15-Deoxy-Delta12 ,14 - prostaglandin_J2 and peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- levels in term placental tissues from control and diabetic rats : modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism .
16038777	0	PPARgamma	66,75	peroxisome_proliferator-activated_receptor_gamma	16,64	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Pivotal role of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in regulation of erythroid progenitor cell proliferation and differentiation .
16574647	0	PPARgamma	65,74	peroxisome_proliferator-activated_receptor_gamma	15,63	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	Attenuation|appos|START_ENTITY Attenuation|nmod|END_ENTITY	Attenuation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- mediates gastrin-stimulated colorectal_cancer cell proliferation .
17122083	0	PPARgamma	64,73	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo .
18209083	0	PPARgamma	64,73	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration_of_HIV-1_infected monocytes .
20028987	0	PPARgamma	58,67	peroxisome_proliferator-activated_receptor_gamma	8,56	PPARgamma	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Chronic peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent , UCP1-containing adipocytes molecularly distinct from classic brown adipocytes .
21572083	0	PPARgamma	68,77	peroxisome_proliferator-activated_receptor_gamma	18,66	PPARgamma	peroxisome proliferator-activated receptor gamma	19016(Tax:10090)	19016(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chemerin , a novel peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- target gene that promotes mesenchymal stem cell adipogenesis .
9642130	0	PPARgamma	64,73	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	peroxisome proliferator-activated receptor gamma	25664(Tax:10116)	25664(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in rat aortic smooth muscle cells .
10762291	0	PPARgamma	66,75	peroxisome_proliferator_activated_receptor_gamma	16,64	PPARgamma	peroxisome proliferator activated receptor gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- gene in HAIRAN_syndrome with obesity .
10073956	0	PPARgamma	0,9	plasminogen_activator_inhibitor_type-1	58,96	PPARgamma	plasminogen activator inhibitor type-1	5468	5054	Gene	Gene	activation|compound|START_ENTITY increases|nsubj|activation increases|dobj|expression expression|amod|END_ENTITY	PPARgamma activation in human endothelial cells increases plasminogen_activator_inhibitor_type-1 expression : PPARgamma as a potential mediator in vascular_disease .
10073956	0	PPARgamma	109,118	plasminogen_activator_inhibitor_type-1	58,96	PPARgamma	plasminogen activator inhibitor type-1	5468	5054	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	PPARgamma activation in human endothelial cells increases plasminogen_activator_inhibitor_type-1 expression : PPARgamma as a potential mediator in vascular_disease .
17439324	0	PPARgamma-2	80,91	peroxisome_proliferator-activated_receptor-gamma2	29,78	PPARgamma-2	peroxisome proliferator-activated receptor-gamma2	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pro12Ala polymorphism of the peroxisome_proliferator-activated_receptor-gamma2 -LRB- PPARgamma-2 -RRB- gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population .
18845124	0	PPARgamma2	39,49	Cidec	30,35	PPARgamma2	Cidec	19016(Tax:10090)	14311(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of Cidec by PPARgamma2 in adipocyte .
23531513	0	PPARy	15,20	AICAR	0,5	PPARy	AICAR	5468	471	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	AICAR inhibits PPARy during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids .
25146391	0	PPARy	54,59	AIMP1	0,5	PPARy	AIMP1	5468	9255	Gene	Gene	inhibiting|dobj|START_ENTITY regulates|advcl|inhibiting regulates|nsubj|END_ENTITY	AIMP1 negatively regulates adipogenesis by inhibiting PPARy .
25122005	0	PPARy	31,36	AT1_receptor	51,63	PPARy	AT1 receptor	5468	11610(Tax:10090)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Role of vascular smooth muscle PPARy in regulating AT1_receptor signaling and angiotensin II-dependent hypertension .
26813964	0	PPARy	0,5	Apolipoprotein_A-I	16,34	PPARy	Apolipoprotein A-I	5468	335	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	PPARy Represses Apolipoprotein_A-I Gene but Impedes TNFa-Mediated ApoA-I Downregulation in HepG2 Cells .
26504087	0	PPARy	51,56	CD36	60,64	PPARy	CD36	5468	948	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	ROS mediates p300-dependent STAT1 interaction with PPARy in CD36 expression and foam cell formation .
25071153	0	PPARy	23,28	Gcn5	0,4	PPARy	Gcn5	5468	2648	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Gcn5 and PCAF regulate PPARy and Prdm16 expression to facilitate brown adipogenesis .
26721185	0	PPARy	0,5	HMGB1	15,20	PPARy	HMGB1	5468	3146	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	PPARy inhibits HMGB1 expression through upregulation of miR-142-3p in vitro and in vivo .
22684020	0	PPARy	37,42	KEAP1	19,24	PPARy	KEAP1	5468	9817	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Regulatory role of KEAP1 and NRF2 in PPARy expression and chemoresistance in human non-small-cell_lung_carcinoma cells .
23627357	0	PPARy	17,22	Lipin1	0,6	PPARy	Lipin1	5468	23175	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Lipin1 regulates PPARy transcriptional activity .
26944559	0	PPARy	22,27	MyoD	0,4	PPARy	MyoD	5468	4654	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	MyoD promotes porcine PPARy gene expression through an E-box and a MyoD-binding site in the PPARy promoter region .
22843091	0	PPARy	21,26	NR0B1	30,35	PPARy	NR0B1	5468	190	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of PPARy on NR0B1 in tumorigenesis of lung_adenocarcinoma .
22481913	0	PPARy	0,5	NRF2	46,50	PPARy	NRF2	5468	4780	Gene	Gene	Stress|compound|START_ENTITY Stress|dep|Con Con|dep|END_ENTITY	PPARy and Oxidative Stress : Con -LRB- b -RRB- Catenating NRF2 and FOXO .
25430543	0	PPARy	20,25	Nrf2	85,89	PPARy	Nrf2	5468	4780	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Pleiotropic Role of PPARy in Intracerebral_Hemorrhage : An Intricate System Involving Nrf2 , RXR , and NF-kB .
23320500	0	PPARy	69,74	PPM1B	33,38	PPARy	PPM1B	5468	5495	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	The serine/threonine phosphatase PPM1B -LRB- PP2Cb -RRB- selectively modulates PPARy activity .
26336103	0	PPARy	147,152	Peroxisome_Proliferative-activated_Receptor-y	100,145	PPARy	Peroxisome Proliferative-activated Receptor-y	5468	5468	Gene	Gene	Activation|appos|START_ENTITY Activation|compound|END_ENTITY	The Synergistic Enhancement of Cloning Efficiency in Individualized Human Pluripotent Stem Cells by Peroxisome_Proliferative-activated_Receptor-y -LRB- PPARy -RRB- Activation and Rho-associated Kinase -LRB- ROCK -RRB- Inhibition .
25987855	0	PPARy	63,68	Peroxisome_Proliferator-Activated_Receptor_Gamma	13,61	PPARy	Peroxisome Proliferator-Activated Receptor Gamma	5468	5468	Gene	Gene	Functions|appos|START_ENTITY Functions|nmod|END_ENTITY	Functions of Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPARy -RRB- in Gynecologic_Disorders .
25987855	0	PPARy	63,68	Peroxisome_Proliferator-Activated_Receptor_Gamma	13,61	PPARy	Peroxisome Proliferator-Activated Receptor Gamma	5468	5468	Gene	Gene	Functions|appos|START_ENTITY Functions|nmod|END_ENTITY	Functions of Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPARy -RRB- in Gynecologic_Disorders .
23939428	0	PPARy	43,48	Skp2	0,4	PPARy	Skp2	5468	6502	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Skp2 regulates subcellular localization of PPARy by MEK signaling pathways in human breast_cancer .
22268140	0	PPARy	22,27	Thy-1	0,5	PPARy	Thy-1	5468	7070	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Thy-1 signals through PPARy to promote lipofibroblast differentiation in the developing lung .
22884583	0	PPARy	138,143	VDR	153,156	PPARy	VDR	5468	7421	Gene	Gene	binds|compound|START_ENTITY binds|nmod|END_ENTITY	Crosstalk between the peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- and the vitamin_D_receptor -LRB- VDR -RRB- in human breast_cancer cells : PPARy binds to VDR and inhibits 1a,25-dihydroxyvitamin _ D3 mediated transactivation .
26814431	0	PPARy	21,26	VEGF	93,97	PPARy	VEGF	5468	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Fatty_acid activated PPARy promotes tumorigenicity of prostate_cancer cells by up regulating VEGF via PPAR responsive elements of the promoter .
25734982	0	PPARy	95,100	apolipoprotein_A-I	38,56	PPARy	apolipoprotein A-I	5468	335	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	A novel compound 4010B-30 upregulates apolipoprotein_A-I gene expression through activation of PPARy in HepG2 cells .
25044948	0	PPARy	101,106	monocyte_chemoattractant_protein-1	51,85	PPARy	monocyte chemoattractant protein-1	5468	6347	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Docosahexaenoic_acid reduces linoleic_acid induced monocyte_chemoattractant_protein-1 expression via PPARy and nuclear factor-kB pathway in retinal pigment epithelial cells .
25646693	0	PPARy	0,5	myostatin	47,56	PPARy	myostatin	5468	2660	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	PPARy and MyoD are differentially regulated by myostatin in adipose-derived stem cells and muscle satellite cells .
19587804	0	PPARy	71,76	peroxisome_proliferator-activated_receptor-y	25,69	PPARy	peroxisome proliferator-activated receptor-y	5468	5468	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	New target genes for the peroxisome_proliferator-activated_receptor-y -LRB- PPARy -RRB- antitumour activity : Perspectives from the insulin_receptor .
25592041	0	PPARy	60,65	peroxisome_proliferator-activated_receptor-y	14,58	PPARy	peroxisome proliferator-activated receptor-y	5468	5468	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-y -LRB- PPARy -RRB- inhibits hepatoma cell growth via downregulation of SEPT2 expression .
23266668	0	PPARy	85,90	peroxisome_proliferator-activated_receptor_gamma	30,78	PPARy	peroxisome proliferator-activated receptor gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The C161T polymorphism in the peroxisome_proliferator-activated_receptor_gamma gene -LRB- PPARy -RRB- is associated with risk of coronary_artery_disease : a meta-analysis .
21104228	0	PPARy	67,72	peroxisome_proliferator-activated_receptor_y	21,65	PPARy	peroxisome proliferator-activated receptor y	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of the peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- gene are associated with osteoporosis .
23826177	0	PPARy	88,93	peroxisome_proliferator-activated_receptor_y	42,86	PPARy	peroxisome proliferator-activated receptor y	5468	5468	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Ligand binding reduces SUMOylation of the peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- activation function 1 -LRB- AF1 -RRB- domain .
24072712	0	PPARy	115,120	peroxisome_proliferator-activated_receptor_y	69,113	PPARy	peroxisome proliferator-activated receptor y	5468	5468	Gene	Gene	stability|appos|START_ENTITY stability|amod|END_ENTITY	Herpesvirus-associated_ubiquitin-specific_protease -LRB- HAUSP -RRB- modulates peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- stability through its deubiquitinating activity .
22361822	0	PPARy2	120,126	Protein_arginine_methyltransferase_5	0,36	PPARy2	Protein arginine methyltransferase 5	5468	10419	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Protein_arginine_methyltransferase_5 -LRB- Prmt5 -RRB- promotes gene expression of peroxisome_proliferator-activated_receptor_y2 -LRB- PPARy2 -RRB- and its target genes during adipogenesis .
23300871	0	PPARy2	90,96	peroxisome_proliferator-activated_receptor_gamma-2	33,83	PPARy2	peroxisome proliferator-activated receptor gamma-2	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor_gamma-2 gene -LRB- PPARy2 -RRB- is associated with increased risk of coronary_artery_disease : a meta-analysis .
22244380	0	PPIase	59,65	FKBP22	78,84	PPIase	FKBP22	2289	55033	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Role of polar and nonpolar residues at the active site for PPIase activity of FKBP22 from Shewanella sp .
18258190	0	PPIase	62,68	hCyP33	81,87	PPIase	hCyP33	23759	10450	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Human CyP33 binds specifically to mRNA and binding stimulates PPIase activity of hCyP33 .
23320500	0	PPM1B	33,38	PPARy	69,74	PPM1B	PPARy	5495	5468	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	The serine/threonine phosphatase PPM1B -LRB- PP2Cb -RRB- selectively modulates PPARy activity .
23556002	0	PPM1D	45,50	Protein_phosphatase_magnesium-dependent_1	0,41	PPM1D	Protein phosphatase magnesium-dependent 1	8493	8493	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Protein_phosphatase_magnesium-dependent_1 -LRB- PPM1D -RRB- mRNA expression is a prognosis marker for hepatocellular_carcinoma .
25590690	0	PPM1D	0,5	p21	16,19	PPM1D	p21	612934(Tax:9615)	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	PPM1D regulates p21 expression via dephoshporylation at serine 123 .
16352595	0	PPM1D	31,36	progesterone_receptor	51,72	PPM1D	progesterone receptor	8493	5241	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Dual roles for the phosphatase PPM1D in regulating progesterone_receptor function .
17426955	0	PPO	41,44	polyphenol_oxidase	21,39	PPO	polyphenol oxidase	543157(Tax:4565)	543157(Tax:4565)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Allelic variation of polyphenol_oxidase -LRB- PPO -RRB- genes located on chromosomes 2A and 2D and development of functional markers for the PPO genes in common_wheat .
23461298	0	PPO	72,75	polyphenol_oxidase	52,70	PPO	polyphenol oxidase	5498	5498	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Polyphenolic composition , antioxidant activity , and polyphenol_oxidase -LRB- PPO -RRB- activity of quince -LRB- Cydonia oblonga Miller -RRB- varieties .
25882427	0	PPO	44,47	polyphenol_oxidase	24,42	PPO	polyphenol oxidase	5498	5498	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Real-time evaluation of polyphenol_oxidase -LRB- PPO -RRB- activity in lychee pericarp based on weighted combination of spectral data and image features as determined by fuzzy neural network .
12655566	0	PPOX	128,132	protoporphyrinogen_oxidase	100,126	PPOX	protoporphyrinogen oxidase	5498	5498	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic analysis of variegate_porphyria -LRB- VP -RRB- in Italy : identification of six novel mutations in the protoporphyrinogen_oxidase -LRB- PPOX -RRB- gene .
8575762	0	PPOX	43,47	protoporphyrinogen_oxidase	10,36	PPOX	protoporphyrinogen oxidase	5498	5498	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human protoporphyrinogen_oxidase gene -LRB- PPOX -RRB- : organization and location to chromosome 1 .
23418347	0	PPP1R15	50,57	eIF2a	25,30	PPP1R15	eIF2a	37820(Tax:7227)	32617(Tax:7227)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Coordinate regulation of eIF2a phosphorylation by PPP1R15 and GCN2 is required during Drosophila development .
23459765	0	PPP1R1B	11,18	DARPP-32	20,28	PPP1R1B	DARPP-32	84152	84152	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Effects of PPP1R1B -LRB- DARPP-32 -RRB- Polymorphism on Feedback-Related Brain Potentials Across the Life Span .
24019952	0	PPP1R26P1	6,15	Rb1	61,64	PPP1R26P1	Rb1	100418740	19645(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Human PPP1R26P1 functions as cis-repressive element in mouse Rb1 .
25846879	0	PPP1R3C	106,113	protein_phosphatase_1_regulatory_subunit_3C	61,104	PPP1R3C	protein phosphatase 1 regulatory subunit 3C	5507	5507	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The effect of high glucose levels on the hypermethylation of protein_phosphatase_1_regulatory_subunit_3C -LRB- PPP1R3C -RRB- gene in colorectal_cancer .
23718219	0	PPP1R42	0,7	PP1	11,14	PPP1R42	PP1	286187	5540	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	PPP1R42 , a PP1 binding protein , regulates centrosome dynamics in ARPE-19 cells .
10713707	0	PPP2R1A	43,50	PPP2R1B	62,69	PPP2R1A	PPP2R1B	5518	5519	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Low frequency of alterations of the alpha -LRB- PPP2R1A -RRB- and beta -LRB- PPP2R1B -RRB- isoforms of the subunit A of the serine-threonine phosphatase_2A in human neoplasms .
10713707	0	PPP2R1B	62,69	PPP2R1A	43,50	PPP2R1B	PPP2R1A	5519	5518	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Low frequency of alterations of the alpha -LRB- PPP2R1A -RRB- and beta -LRB- PPP2R1B -RRB- isoforms of the subunit A of the serine-threonine phosphatase_2A in human neoplasms .
24514563	0	PPP3CA	119,125	protein_phosphatase_3_catalytic_subunit_alpha_isoform	64,117	PPP3CA	protein phosphatase 3 catalytic subunit alpha isoform	102176770	102176770	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning , structural analysis and tissue expression of protein_phosphatase_3_catalytic_subunit_alpha_isoform -LRB- PPP3CA -RRB- gene in Tianfu goat muscle .
23167795	0	PPT	28,31	Slc2a4	43,49	PPT	Slc2a4	6863	6517	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Estrogen_receptor_1 agonist PPT stimulates Slc2a4 gene expression and improves insulin-induced glucose uptake in adipocytes .
12091546	0	PPT-A	40,45	substance_P	25,36	PPT-A	substance P	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Long-term deprivation of substance_P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network .
10649502	0	PPT1	81,85	palmitoyl-protein_thioesterase-1	47,79	PPT1	palmitoyl-protein thioesterase-1	5538	5538	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of three novel mutations of the palmitoyl-protein_thioesterase-1 -LRB- PPT1 -RRB- gene in children with neuronal_ceroid-lipofuscinosis .
7782089	0	PPY	95,98	pancreatic_polypeptide	66,88	PPY	pancreatic polypeptide	5539	5539	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gene duplication of the human peptide_YY gene -LRB- PYY -RRB- generated the pancreatic_polypeptide gene -LRB- PPY -RRB- on chromosome 17q21 .1 .
10332029	0	PQBP-1	0,6	Brn-2	90,95	PQBP-1	Brn-2	54633(Tax:10090)	18992(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	PQBP-1 , a novel polyglutamine tract-binding protein , inhibits transcription activation by Brn-2 and affects cell survival .
23874697	0	PQBP1	33,38	Sox2	0,4	PQBP1	Sox2	54633(Tax:10090)	20674(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Sox2 transcriptionally regulates PQBP1 , an intellectual_disability-microcephaly causative gene , in neural stem progenitor cells .
15355434	0	PQBP1	105,110	polyglutamine-binding_protein_1	67,98	PQBP1	polyglutamine-binding protein 1	10084	10084	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotype-phenotype studies in three families with mutations in the polyglutamine-binding_protein_1 gene -LRB- PQBP1 -RRB- .
16033082	0	PR	165,167	ER-alpha	94,102	PR	ER-alpha	5241	2099	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Normal and malignant human endometrium express immunohistochemically estrogen receptor alpha -LRB- ER-alpha -RRB- , estrogen receptor beta -LRB- ER-beta -RRB- and progesterone_receptor -LRB- PR -RRB- .
12552233	0	PR	78,80	ERalpha	31,38	PR	ERalpha	5241	2099	Gene	Gene	estrogen_receptor|appos|START_ENTITY estrogen_receptor|appos|END_ENTITY	Analysis of estrogen_receptor -LRB- ERalpha and ERbeta -RRB- and progesterone_receptor -LRB- PR -RRB- polymorphisms in uterine leiomyomas .
21623202	0	PR	118,120	p53	122,125	PR	p53	5241	7157	Gene	Gene	Ki-67|compound|START_ENTITY Ki-67|dep|END_ENTITY	Assessing the impact of polysomy-17 on HER2 status and the correlations of HER2 status with prognostic variables -LRB- ER , PR , p53 , Ki-67 -RRB- in epithelial_ovarian_cancer : a tissue microarray study using immunohistochemistry and fluorescent in situ hybridization .
18621128	0	PR	74,76	progesterone_receptor	51,72	PR	progesterone receptor	100724945	100724945	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regional changes in the spatio-temporal pattern of progesterone_receptor -LRB- PR -RRB- expression in the guinea-pig genital tract as parturition approaches .
9717846	0	PR	44,46	progesterone_receptor	21,42	PR	progesterone receptor	25154(Tax:10116)	25154(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Hormone induction of progesterone_receptor -LRB- PR -RRB- messenger ribonucleic_acid and activation of PR promoter regions in ovarian granulosa cells : evidence for a role of cyclic_adenosine_3 ' ,5 ' - monophosphate but not estradiol .
24929581	0	PR-39	52,57	ETEC	113,117	PR-39	ETEC	407610(Tax:9823)	106455643	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of porcine antimicrobial peptide PR-39 and its induction by enterotoxigenic Escherichia coli -LRB- ETEC -RRB- F4ac .
11725949	0	PR1-like	24,32	AtPRB1	39,45	PR1-like	AtPRB1	816518(Tax:3702)	815945(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The promoter of a basic PR1-like gene , AtPRB1 , from Arabidopsis establishes an organ-specific expression pattern and responsiveness to ethylene and methyl_jasmonate .
10103046	0	PR3	44,47	proteinase_3	30,42	PR3	proteinase 3	5657	5657	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of purified human proteinase_3 -LRB- PR3 -RRB- with reconstituted lipid bilayers .
11373297	0	PRA1	21,25	BHRF1	86,91	PRA1	BHRF1	10567	3783706(Tax:10376)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	The cellular protein PRA1 modulates the anti-apoptotic activity of Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , through direct interaction .
10751420	0	PRA1	0,4	GDI1	61,65	PRA1	GDI1	10567	2664	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1 .
8547115	0	PRAD-1	28,34	CCND1	35,40	PRAD-1	CCND1	595	595	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Increased expression of the PRAD-1 / CCND1 gene in hairy_cell_leukaemia .
7919385	0	PRAD-1	0,6	cyclin_D1	7,16	PRAD-1	cyclin D1	595	595	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|END_ENTITY	PRAD-1 / cyclin_D1 gene overexpression in chronic lymphoproliferative_disorders : a highly specific marker of mantle_cell_lymphoma .
8626826	0	PRAD1	10,15	Cyclin_D1	0,9	PRAD1	Cyclin D1	595	595	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Cyclin_D1 / PRAD1 expression in parathyroid_adenomas : an immunohistochemical study .
9065811	0	PRAD1	11,16	Cyclin_D1	0,9	PRAD1	Cyclin D1	595	595	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Cyclin_D1 -LRB- PRAD1 -RRB- alternative transcript b : full-length cDNA cloning and expression in breast_cancers .
15580289	0	PRAD1	100,105	cyclin_D1	90,99	PRAD1	cyclin D1	595	595	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Parafibromin , product of the hyperparathyroidism-jaw_tumor_syndrome_gene_HRPT2 , regulates cyclin_D1 / PRAD1 expression .
25383140	0	PRAK	0,4	DJ-1	20,24	PRAK	DJ-1	17165(Tax:10090)	57320(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PRAK interacts with DJ-1 and prevents oxidative stress-induced cell death .
23734332	0	PRAME	11,16	CD8	35,38	PRAME	CD8	23532	925	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	Priming of PRAME - and WT1-specific CD8 -LRB- + -RRB- T cells in healthy donors but not in AML patients in complete remission : Implications for immunotherapy .
18587578	0	PRAME	54,59	PRAME	76,81	PRAME	PRAME	23532	23532	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute_myeloid_leukemia .
18587578	0	PRAME	76,81	PRAME	54,59	PRAME	PRAME	23532	23532	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Aberrant hypomethylation of the cancer-testis antigen PRAME correlates with PRAME expression in acute_myeloid_leukemia .
22490886	0	PRAS40	60,66	Insulin-like_growth_factor-1	0,28	PRAS40	Insulin-like growth factor-1	292887(Tax:10116)	24482(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells .
22873724	0	PRAS40	59,65	Wnt1_inducible_signaling_pathway_protein_1	0,42	PRAS40	Wnt1 inducible signaling pathway protein 1	84335	8840	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Wnt1_inducible_signaling_pathway_protein_1 -LRB- WISP1 -RRB- targets PRAS40 to govern b-amyloid apoptotic injury of microglia .
17510057	0	PRAS40	0,6	mTORC1	17,23	PRAS40	mTORC1	84335	382056(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding .
26876939	0	PRAS40	72,78	mTORC1	0,6	PRAS40	mTORC1	84335	382056(Tax:10090)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|amod|END_ENTITY	mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress .
18372248	0	PRAS40	52,58	mammalian_target_of_rapamycin	72,101	PRAS40	mammalian target of rapamycin	84335	2475	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Regulation of proline-rich_Akt_substrate_of_40_kDa -LRB- PRAS40 -RRB- function by mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- - mediated phosphorylation .
22447933	0	PRAT4A	79,85	TLR1	28,32	PRAT4A	TLR1	10695	7096	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|trafficking trafficking|nmod|END_ENTITY	Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B .
19561070	0	PRC1	0,4	CLASP1	21,27	PRC1	CLASP1	9055	23332	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis .
25801166	0	PRC1	13,17	Cbx2	0,4	PRC1	Cbx2	233406(Tax:10090)	12416(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner .
14744859	0	PRC1	41,45	Cdc42	81,86	PRC1	Cdc42	9055	998	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase .
15341744	0	PRC1	31,35	Feo	0,3	PRC1	Feo	32015(Tax:7227)	32015(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Feo , the Drosophila homolog of PRC1 , is required for central-spindle formation and cytokinesis .
18570919	0	PRC1	0,4	HSF2	60,64	PRC1	HSF2	233406(Tax:10090)	15500(Tax:10090)	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	PRC1 associates with the hsp70i promoter and interacts with HSF2 during mitosis .
15297875	0	PRC1	48,52	KIF4	19,23	PRC1	KIF4	9055	24137	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation .
14744859	0	PRC1	41,45	MgcRacGAP	55,64	PRC1	MgcRacGAP	9055	29127	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase .
22621898	0	PRC1	26,30	Plk1	0,4	PRC1	Plk1	9055	5347	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis .
15531928	0	PRC1	18,22	p53	30,33	PRC1	p53	9055	7157	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis .
15531928	0	PRC1	18,22	p53	75,78	PRC1	p53	9055	7157	Gene	Gene	Identification|nmod|START_ENTITY uncovers|nsubj|Identification uncovers|dobj|function function|nmod|END_ENTITY	Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis .
19171072	0	PRCP	40,44	prolylcarboxypeptidase	16,38	PRCP	prolylcarboxypeptidase	5547	5547	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of prolylcarboxypeptidase -LRB- PRCP -RRB- in lipopolysaccharide -LRB- LPS -RRB- treated endothelium promotes inflammation .
14985713	0	PRDI-BF1	0,8	G9a	51,54	PRDI-BF1	G9a	639	10919	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing .
16849320	0	PRDI-binding_factor-1	96,117	viperin	46,53	PRDI-binding factor-1	viperin	639	91543	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Toll-like receptor-dependent and - independent viperin gene expression and counter-regulation by PRDI-binding_factor-1 / BLIMP1 .
20966935	0	PRDM1	68,73	BCL-6	96,101	PRDM1	BCL-6	639	604	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Follicular dendritic cell-induced microRNA-mediated upregulation of PRDM1 and downregulation of BCL-6 in non-Hodgkin 's B-cell_lymphomas .
19234190	0	PRDM1	8,13	Blimp-1	0,7	PRDM1	Blimp-1	639	639	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Blimp-1 / PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch -1 .
26310579	0	PRDM1	8,13	Blimp-1	0,7	PRDM1	Blimp-1	639	639	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Blimp-1 / PRDM1 regulates the transcription of human CS1 -LRB- SLAMF7 -RRB- gene in NK and B cells .
24527393	0	PRDM1	48,53	SOX2	19,23	PRDM1	SOX2	639	6657	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells .
26096175	0	PRDM1	0,5	Tumor-Suppressor	9,25	PRDM1	Tumor-Suppressor	639	7248	Gene	Gene	START_ENTITY|appos|Gene Gene|compound|END_ENTITY	PRDM1 , a Tumor-Suppressor Gene , is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells .
25644604	0	PRDM16	0,6	MED1	13,17	PRDM16	MED1	63976	5469	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program .
10862032	0	PRDM2	124,129	RIZ	119,122	PRDM2	RIZ	7799	7799	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mapping of a minimal deleted region in human hepatocellular_carcinoma to 1p36.13-p36 .23 and mutational analysis of the RIZ -LRB- PRDM2 -RRB- gene localized to the region .
25501702	0	PRDM5	41,46	PR_domain_containing_5	17,39	PRDM5	PR domain containing 5	11107	11107	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Emerging role of PR_domain_containing_5 -LRB- PRDM5 -RRB- as a broad tumor suppressor in human cancers .
18941885	0	PRDM9	39,44	MEISETZ	46,53	PRDM9	MEISETZ	56979	56979	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Two single nucleotide polymorphisms in PRDM9 -LRB- MEISETZ -RRB- gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic_arrest .
19168450	0	PRDM9	39,44	MEISETZ	46,53	PRDM9	MEISETZ	56979	56979	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single-nucleotide polymorphisms of the PRDM9 -LRB- MEISETZ -RRB- gene in patients with nonobstructive azoospermia .
19364504	0	PRDX4	49,54	TNF-related_apoptosis-inducing_ligand	0,37	PRDX4	TNF-related apoptosis-inducing ligand	10549	8743	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	TNF-related_apoptosis-inducing_ligand suppresses PRDX4 expression .
10194769	0	PREB	43,47	prolactin_regulatory_element_binding	49,85	PREB	prolactin regulatory element binding	58842(Tax:10116)	58842(Tax:10116)	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Expression cloning and characterization of PREB -LRB- prolactin_regulatory_element_binding -RRB- , a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity .
10784606	0	PRELI	0,5	px19	40,44	PRELI	px19	27166	27166	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	PRELI , the human homologue of the avian px19 , is expressed by germinal center B lymphocytes .
12732210	0	PREP1	0,5	MEIS1	7,12	PREP1	MEIS1	5316	4211	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	PREP1 , MEIS1 homolog protein , regulates PF4 gene expression .
12732210	0	PREP1	0,5	PF4	40,43	PREP1	PF4	5316	5196	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	PREP1 , MEIS1 homolog protein , regulates PF4 gene expression .
25238774	0	PRF1	27,31	CD8	33,36	PRF1	CD8	5551	925	Gene	Gene	Response|compound|START_ENTITY Response|compound|END_ENTITY	IFNy-TNFa-IL2-MIP1a-CD107a + PRF1 + CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans .
23073290	0	PRF1	42,46	perforin	47,55	PRF1	perforin	5551	5551	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Functional impact of A91V mutation of the PRF1 perforin gene .
11124536	0	PRG4	63,67	proteoglycan_4	69,83	PRG4	proteoglycan 4	10216	10216	Gene	Gene	genes|compound|START_ENTITY genes|nummod|END_ENTITY	Isolation , characterization and mapping of the mouse and human PRG4 -LRB- proteoglycan_4 -RRB- genes .
26643105	0	PRG4	113,117	toll-like_receptors_2_and_4	55,82	PRG4	toll-like receptors 2 and 4	10216	7097;7099	Gene	Gene	role|nmod|START_ENTITY interaction|dep|role interaction|nmod|END_ENTITY	The interaction of lubricin/proteoglycan _ 4 -LRB- PRG4 -RRB- with toll-like_receptors_2_and_4 : an anti-inflammatory role of PRG4 in synovial fluid .
24312498	0	PRICKLE1	0,8	SYNAPSIN_I	26,36	PRICKLE1	SYNAPSIN I	106042(Tax:10090)	20964(Tax:10090)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	PRICKLE1 interaction with SYNAPSIN_I reveals a role in autism_spectrum_disorders .
16619536	0	PRIMA-1	11,18	p53	62,65	PRIMA-1	p53	170952(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53 : necrosis vs. apoptosis .
16909106	0	PRIMA-1	0,7	p53	54,57	PRIMA-1	p53	145270	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|accumulation accumulation|nmod|END_ENTITY	PRIMA-1 -LRB- MET -RRB- induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins .
25981537	0	PRIP	15,19	Phospholipase_C-Related_But_Catalytically_Inactive_Protein	21,79	PRIP	Phospholipase C-Related But Catalytically Inactive Protein	227120(Tax:10090)	227120(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of PRIP -LRB- Phospholipase_C-Related_But_Catalytically_Inactive_Protein -RRB- in BMP-Induced Smad Signaling in Osteoblast Differentiation .
16505254	0	PRKAA2	102,108	PRKAB1	110,116	PRKAA2	PRKAB1	5563	5564	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Haplotype structures and large-scale association testing of the 5 ' _ AMP-activated protein kinase genes PRKAA2 , PRKAB1 , and PRKAB2 -LSB- corrected -RSB- with type 2 diabetes .
16505254	0	PRKAB1	110,116	PRKAA2	102,108	PRKAB1	PRKAA2	5564	5563	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Haplotype structures and large-scale association testing of the 5 ' _ AMP-activated protein kinase genes PRKAA2 , PRKAB1 , and PRKAB2 -LSB- corrected -RSB- with type 2 diabetes .
21813245	0	PRKAG2	21,27	AMPK	0,4	PRKAG2	AMPK	51422	5563	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	AMPK y2 subunit gene PRKAG2 polymorphism associated with cognitive_impairment as well as diabetes in old age .
19818097	0	PRKAR2A	52,59	protein_kinase_A_RIIa	29,50	PRKAR2A	protein kinase A RIIa	5576	5576	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic modulation of the protein_kinase_A_RIIa -LRB- PRKAR2A -RRB- gene by histone_deacetylases_1_and_2 in human smooth muscle cells .
24737441	0	PRKAR2B	55,62	Protein_kinase_cAMP-dependent_regulatory_type_II_beta	0,53	PRKAR2B	Protein kinase cAMP-dependent regulatory type II beta	5577	5577	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Protein_kinase_cAMP-dependent_regulatory_type_II_beta -LRB- PRKAR2B -RRB- gene variants in antipsychotic-induced weight_gain .
15155525	0	PRKCA	39,44	protein_kinase_C_alpha	15,37	PRKCA	protein kinase C alpha	5578	5578	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of protein_kinase_C_alpha -LRB- PRKCA -RRB- gene with multiple_sclerosis in a UK population .
9856494	0	PRKCB	91,96	protein_kinase_C_beta	63,84	PRKCB	protein kinase C beta	5579	5579	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Elucidation of the exon-intron structure and size of the human protein_kinase_C_beta gene -LRB- PRKCB -RRB- .
16567829	0	PRKCB1	49,55	protein_kinase_C-beta	21,42	PRKCB1	protein kinase C-beta	5579	5579	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of the protein_kinase_C-beta gene -LRB- PRKCB1 -RRB- accelerate kidney disease in type 2 diabetes without overt proteinuria .
25116760	0	PRKCD	44,49	protein_kinase_C_delta	20,42	PRKCD	protein kinase C delta	505708(Tax:9913)	505708(Tax:9913)	Gene	Gene	requirement|appos|START_ENTITY requirement|nmod|END_ENTITY	The requirement for protein_kinase_C_delta -LRB- PRKCD -RRB- during preimplantation bovine embryo development .
8188219	0	PRKCD	59,64	protein_kinase_C_delta	18,40	PRKCD	protein kinase C delta	5580	5580	Gene	Gene	Assignment|appos|START_ENTITY Assignment|nmod|gene gene|compound|END_ENTITY	Assignment of the protein_kinase_C_delta polypeptide gene -LRB- PRKCD -RRB- to human chromosome 3 and mouse chromosome 14 .
17343273	0	PRKCG	0,5	SCA-14	16,22	PRKCG	SCA-14	5582	5582	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	PRKCG mutation -LRB- SCA-14 -RRB- causing a Ramsay Hunt phenotype .
17508994	0	PRKCG	39,44	protein_kinase_C_gamma	10,32	PRKCG	protein kinase C gamma	5582	5582	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human protein_kinase_C_gamma gene -LRB- PRKCG -RRB- as a susceptibility locus for behavioral_disinhibition .
21756056	0	PRKCH	62,67	protein_kinase_C-Eta	40,60	PRKCH	protein kinase C-Eta	5583	5583	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Contribution of 1425G/A polymorphism in protein_kinase_C-Eta -LRB- PRKCH -RRB- gene and brain white_matter_lesions to the risk of sudden_sensorineural_hearing_loss in a Japanese nested case-control study .
25356169	0	PRKCI	70,75	miR-219	0,7	PRKCI	miR-219	5584	407002	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-219 inhibits the growth and metastasis of TSCC cells by targeting PRKCI .
21252065	0	PRKCQ	70,75	RUNX1	107,112	PRKCQ	RUNX1	5588	861	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Platelet protein kinase C-theta deficiency with human RUNX1 mutation : PRKCQ is a transcriptional target of RUNX1 .
21252065	0	PRKCQ	70,75	RUNX1	54,59	PRKCQ	RUNX1	5588	861	Gene	Gene	target|nsubj|START_ENTITY kinase|parataxis|target kinase|nmod|mutation mutation|compound|END_ENTITY	Platelet protein kinase C-theta deficiency with human RUNX1 mutation : PRKCQ is a transcriptional target of RUNX1 .
7686884	0	PRKR	80,84	p68	63,66	PRKR	p68	5610	10657	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human interferon-induced , ds-RNA activated p68 kinase gene -LRB- PRKR -RRB- to chromosome 2p21-p22 .
11751586	0	PRL	18,21	Akt	34,37	PRL	Akt	24683(Tax:10116)	24185(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the PRL promoter by Akt through cAMP response element binding protein .
2759338	0	PRL	11,14	Prolactin	0,9	PRL	Prolactin	5617	5617	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Prolactin -LRB- PRL -RRB- mRNA from human decidua differs from pituitary PRL mRNA but resembles the IM-9-P3 lymphoblast PRL transcript .
12970160	0	PRL	25,28	prolactin	14,23	PRL	prolactin	5617	5617	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of prolactin -LRB- PRL -RRB- - induced proliferative signals in breast_cancer cells by a molecular mimic of phosphorylated PRL , S179D-PRL .
16648817	0	PRL	52,55	prolactin	36,45	PRL	prolactin	280901(Tax:9913)	280901(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel polymorphism of the porcine prolactin gene -LRB- PRL -RRB- .
3137402	0	PRL	84,87	prolactin	73,82	PRL	prolactin	5617	5617	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Use of a pharmacokinetic model to characterize the thyrotropin -LRB- TSH -RRB- and prolactin -LRB- PRL -RRB- response to thyrotropin-releasing_hormone -LRB- THR -RRB- in man .
6196473	0	PRL	25,28	prolactin	14,23	PRL	prolactin	5617	5617	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of prolactin -LRB- PRL -RRB- on human fetal lung and liver protein synthesis in vitro .
6349706	0	PRL	38,41	prolactin	27,36	PRL	prolactin	5617	5617	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunofluorescent study on prolactin -LRB- PRL -RRB- synthesis in human fetal adenohypophysis .
7997234	0	PRL	29,32	prolactin	18,27	PRL	prolactin	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of rat prolactin -LRB- PRL -RRB- storage by coexpression of human PRL .
23867504	0	PRL-3	22,27	EGFR	36,40	PRL-3	EGFR	11156	1956	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells .
18078820	0	PRL-3	70,75	Ezrin	0,5	PRL-3	Ezrin	11156	7430	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3 .
24885636	0	PRL-3	101,106	KCNN4	112,117	PRL-3	KCNN4	11156	3783	Gene	Gene	START_ENTITY|nmod|manner manner|compound|END_ENTITY	Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner .
24686170	0	PRL-3	21,26	LEO1	0,4	PRL-3	LEO1	11156	123169	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute_myelogenous_leukemia .
17409395	0	PRL-3	0,5	PTEN	21,25	PRL-3	PTEN	10879	5728	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition .
21555304	0	PRL-3	34,39	PTP4A3	41,47	PRL-3	PTP4A3	11156	11156	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical assessment of PRL-3 -LRB- PTP4A3 -RRB- expression in tumor buds , invasion front , central region of tumor and metastases of colorectal_cancer .
21084277	0	PRL-3	12,17	TGFbeta	51,58	PRL-3	TGFbeta	11156	7040	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon_cancer metastasis .
23418787	0	PRL-3	0,5	c-Fos	17,22	PRL-3	c-Fos	11156	2353	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	PRL-3 suppresses c-Fos and integrin a2 expression in ovarian_cancer cells .
19115206	0	PRL-3	55,60	keratin_8	19,28	PRL-3	keratin 8	11156	3856	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Down-modulation of keratin_8 phosphorylation levels by PRL-3 contributes to colorectal_carcinoma progression .
26597054	0	PRL-3	0,5	mTORC1	16,22	PRL-3	mTORC1	19245(Tax:10090)	382056(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	PRL-3 activates mTORC1 in Cancer Progression .
19854191	0	PRL-L	32,37	prolactin-like_protein	8,30	PRL-L	prolactin-like protein	417800(Tax:9031)	417800(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel prolactin-like_protein -LRB- PRL-L -RRB- gene in chickens and zebrafish : cloning and characterization of its tissue expression .
23523997	0	PRL-L	32,37	prolactin-like_protein	8,30	PRL-L	prolactin-like protein	417800(Tax:9031)	417800(Tax:9031)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of prolactin-like_protein -LRB- PRL-L -RRB- in cold-induced increase of muscle mass in chicks .
8987522	0	PRL-R	36,41	prolactin_receptor	16,34	PRL-R	prolactin receptor	19116(Tax:10090)	19116(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modification of prolactin_receptor -LRB- PRL-R -RRB- expression by PRL in the mouse liver : estimation of the ratio of two forms of PRL-R mRNAs by `` one-sided competitive PCR '' .
9603266	0	PRL-R	69,74	prolactin_receptor	49,67	PRL-R	prolactin receptor	5618	5618	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Developmental expression and localization of the prolactin_receptor -LRB- PRL-R -RRB- gene in ewe mammary gland during pregnancy and lactation : estimation of the ratio of the two forms of PRL-R messenger ribonucleic acid .
19500298	0	PRL1	83,87	PLEIOTROPIC_RESPONSE_LOCUS_1	53,81	PRL1	PLEIOTROPIC RESPONSE LOCUS 1	827272(Tax:3702)	827272(Tax:3702)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Modulation of O-mediated retrograde signaling by the PLEIOTROPIC_RESPONSE_LOCUS_1 -LRB- PRL1 -RRB- protein , a central integrator of stress and energy signaling .
18268019	0	PRL3	67,71	C-terminal_Src_kinase	25,46	PRL3	C-terminal Src kinase	11156	1445	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Translational control of C-terminal_Src_kinase -LRB- Csk -RRB- expression by PRL3 phosphatase .
17192274	0	PRL3	0,4	Csk	68,71	PRL3	Csk	11156	1445	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|down-regulation down-regulation|nmod|END_ENTITY	PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation .
18268019	0	PRL3	67,71	Csk	48,51	PRL3	Csk	11156	1445	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Translational control of C-terminal_Src_kinase -LRB- Csk -RRB- expression by PRL3 phosphatase .
15885496	0	PRLH	43,47	prolactin-releasing_hormone	14,41	PRLH	prolactin-releasing hormone	51052	51052	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Origin of the prolactin-releasing_hormone -LRB- PRLH -RRB- receptors : evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution .
20349144	0	PRLR	59,63	prolactin_receptor	39,57	PRLR	prolactin receptor	281422(Tax:9913)	281422(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphisms of the prolactin_receptor -LRB- PRLR -RRB- gene and its association with growth traits in Chinese cattle .
21816901	0	PRLr	64,68	HMGN2	0,5	PRLr	HMGN2	5618	3151	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription .
21812980	0	PRLr	91,95	prolactin_receptor	71,89	PRLr	prolactin receptor	479363(Tax:9615)	479363(Tax:9615)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Luteal and placental function in the bitch : spatio-temporal changes in prolactin_receptor -LRB- PRLr -RRB- expression at dioestrus , pregnancy and normal and induced parturition .
22095282	0	PRMT1	63,68	ASK1	45,49	PRMT1	ASK1	3276	4217	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Arginine methylation-dependent regulation of ASK1 signaling by PRMT1 .
26503212	0	PRMT1	31,36	FAM98A	0,6	PRMT1	FAM98A	3276	25940	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	FAM98A is a novel substrate of PRMT1 required for tumor cell migration , invasion , and colony formation .
26825979	0	PRMT1	43,48	FAM98A	12,18	PRMT1	FAM98A	3276	25940	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Erratum to : FAM98A is a novel substrate of PRMT1 required for tumor cell migration , invasion and colony formation .
26911452	0	PRMT1	23,28	PIAS1	43,48	PRMT1	PIAS1	3276	8554	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Specific regulation of PRMT1 expression by PIAS1 and RKIP in BEAS-2B epithelia cells and HFL-1 fibroblasts in lung_inflammation .
25911106	0	PRMT1	55,60	Protein_Arginine_Methyltransferase_1	17,53	PRMT1	Protein Arginine Methyltransferase 1	3276	3276	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Redox Control of Protein_Arginine_Methyltransferase_1 -LRB- PRMT1 -RRB- Activity .
22614839	0	PRMT1	0,5	RAP55	22,27	PRMT1	RAP55	3276	26065	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	PRMT1 is required for RAP55 to localize to processing bodies .
26795953	0	PRMT1	16,21	STAT1	58,63	PRMT1	STAT1	3276	6772	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|activation activation|compound|END_ENTITY	PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts .
18492485	0	PRMT1	15,20	insulin_receptor	65,81	PRMT1	insulin receptor	3276	3643	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of PRMT1 in hnRNPQ activation and internalization of insulin_receptor .
15186775	0	PRMT1	33,38	p53	89,92	PRMT1	p53	3276	7157	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Ordered cooperative functions of PRMT1 , p300 , and CARM1 in transcriptional activation by p53 .
16861234	0	PRMT1	112,117	pS2	100,103	PRMT1	pS2	3276	7031	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1 .
21697082	0	PRMT1	80,85	protein-arginine_methyltransferase_I	42,78	PRMT1	protein-arginine methyltransferase I	3276	3276	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Investigation of the molecular origins of protein-arginine_methyltransferase_I -LRB- PRMT1 -RRB- product specificity reveals a role for two conserved methionine residues .
15473865	0	PRMT3	50,55	Ribosomal_protein_S2	0,20	PRMT3	Ribosomal protein S2	10196	6187	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Ribosomal_protein_S2 is a substrate for mammalian PRMT3 -LRB- protein_arginine_methyltransferase_3 -RRB- .
15670829	0	PRMT5	126,131	FCP1	73,77	PRMT5	FCP1	10419	2221	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	Identification of proteins interacting with the RNAPII FCP1 phosphatase : FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation .
19181385	0	PRMT5	47,52	GANP	0,4	PRMT5	GANP	27374(Tax:10090)	54387(Tax:10090)	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells .
25585209	0	PRMT5	61,66	KAP1	0,4	PRMT5	KAP1	10419	10155	Gene	Gene	Substrate|nmod|START_ENTITY Substrate|nsubj|END_ENTITY	KAP1 is a Novel Substrate for the Arginine Methyltransferase PRMT5 .
24189068	0	PRMT5	38,43	Protein_arginine_methyltransferase_5	0,36	PRMT5	Protein arginine methyltransferase 5	27374(Tax:10090)	27374(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- inhibition induces lymphoma cell death through reactivation of the retinoblastoma_tumor suppressor pathway and polycomb repressor complex 2 -LRB- PRC2 -RRB- silencing .
19741270	0	PRMT5	84,89	ZNF224	37,43	PRMT5	ZNF224	10419	7767	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene .
19520849	0	PRMT5	47,52	pICLn	8,13	PRMT5	pICLn	10419	1207	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of pICLn in methylation of Sm proteins by PRMT5 .
21081503	0	PRMT5	119,124	pICln	87,92	PRMT5	pICln	10419	1207	Gene	Gene	composition|amod|START_ENTITY END_ENTITY|nmod|composition	RioK1 , a new interactor of protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- , competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity .
21081503	0	PRMT5	65,70	pICln	87,92	PRMT5	pICln	10419	1207	Gene	Gene	protein_arginine_methyltransferase_5|appos|START_ENTITY interactor|nmod|protein_arginine_methyltransferase_5 RioK1|appos|interactor competes|nsubj|RioK1 competes|nmod|END_ENTITY	RioK1 , a new interactor of protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- , competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity .
26228443	0	PRMT5	108,113	protein_arginine_methyltransferase-5	70,106	PRMT5	protein arginine methyltransferase-5	480242(Tax:9615)	480242(Tax:9615)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
26294260	0	PRMT5	108,113	protein_arginine_methyltransferase-5	70,106	PRMT5	protein arginine methyltransferase-5	480242(Tax:9615)	480242(Tax:9615)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
19509293	0	PRMT6	59,64	Thrombospondin-1	0,16	PRMT6	Thrombospondin-1	55170	7057	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Thrombospondin-1 is a transcriptional repression target of PRMT6 .
17512914	0	PRMT8	72,77	protein_arginine_methyltransferase_8	34,70	PRMT8	protein arginine methyltransferase 8	381813(Tax:10090)	381813(Tax:10090)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Specific regional distribution of protein_arginine_methyltransferase_8 -LRB- PRMT8 -RRB- in the mouse brain .
17925405	0	PRMT8	52,57	protein_arginine_methyltransferase_8	14,50	PRMT8	protein arginine methyltransferase 8	56341	56341	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regulation of protein_arginine_methyltransferase_8 -LRB- PRMT8 -RRB- activity by its N-terminal domain .
15274317	0	PRND	63,67	doppel	50,56	PRND	doppel	23627	23627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Differential expression of the prion-like protein doppel gene -LRB- PRND -RRB- in astrocytomas : a new molecular marker potentially involved in tumor progression .
15477588	0	PRNP	20,24	Prion_protein	0,13	PRNP	Prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prion_protein gene -LRB- PRNP -RRB- variants and evidence for strong purifying selection in functionally important regions of bovine exon 3 .
16622593	0	PRNP	20,24	Prion_protein	0,13	PRNP	Prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prion_protein gene -LRB- PRNP -RRB- polymorphisms in Xinjiang local sheep breeds in China .
20140032	0	PRNP	20,24	Prion_protein	0,13	PRNP	Prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prion_protein gene -LRB- PRNP -RRB- polymorphisms in native Chinese cattle .
12873216	0	PRNP	83,87	prion_protein	68,81	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Analysis of polymorphic microsatellites within the bovine and ovine prion_protein -LRB- PRNP -RRB- genes .
14727152	0	PRNP	67,71	prion_protein	47,60	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of sequence variability of the bovine prion_protein gene -LRB- PRNP -RRB- in German cattle breeds .
15644519	0	PRNP	67,71	prion_protein	47,60	PRNP	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The incidence of genotypes at codon 171 of the prion_protein gene -LRB- PRNP -RRB- in five breeds of sheep and production traits of ewes associated with those genotypes .
15739100	0	PRNP	89,93	prion_protein	69,82	PRNP	prion protein	5621	5621	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Creutzfeldt-Jakob_disease in a patient with an R208H mutation of the prion_protein gene -LRB- PRNP -RRB- and a 17-kDa prion_protein fragment .
16690731	0	PRNP	40,44	prion_protein	20,33	PRNP	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genotyping of ovine prion_protein gene -LRB- PRNP -RRB- variants by PCR with melting curve analysis .
17272863	0	PRNP	59,63	prion_protein	39,52	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Deletion/insertion polymorphism of the prion_protein gene -LRB- PRNP -RRB- in Polish Holstein-Friesian cattle .
17605301	0	PRNP	38,42	prion_protein	18,31	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the prion_protein gene -LRB- PRNP -RRB- and cellular prion_protein -LRB- PrPc -RRB- in cattle and sheep fetuses and maternal tissues during pregnancy .
18256917	0	PRNP	39,43	prion_protein	24,37	PRNP	prion protein	101087310	101087310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The complete CDS of the prion_protein -LRB- PRNP -RRB- gene of African lion -LRB- Panthera leo -RRB- .
18817311	0	PRNP	60,64	prion_protein	40,53	PRNP	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphism -LRB- SNP -RRB- in prion_protein gene -LRB- PRNP -RRB- exon-3 in Gaddi sheep .
18941882	0	PRNP	58,62	prion_protein	38,51	PRNP	prion protein	102169975	102169975	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Complete genomic sequence of the goat prion_protein gene -LRB- PRNP -RRB- .
19507705	0	PRNP	59,63	prion_protein	39,52	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Deletion/insertion polymorphism of the prion_protein gene -LRB- PRNP -RRB- in Polish red cattle , Polish White-backed cattle and European_bison -LRB- Bison_bonasus L. , 1758 -RRB- .
19534429	0	PRNP	35,39	prion_protein	21,34	PRNP	prion protein	5621	5621	Gene	Gene	START_ENTITY|nsubj|Polymorphism Polymorphism|nmod|END_ENTITY	-LSB- Polymorphism of the prion_protein PRNP gene and risk of multiple_sclerosis development in ethnic Russians from Bashkortostan -RSB- .
20198483	0	PRNP	70,74	prion_protein	50,63	PRNP	prion protein	5621	5621	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel seven-octapeptide repeat insertion in the prion_protein gene -LRB- PRNP -RRB- in a Dutch pedigree with Gerstmann-Str ussler-Scheinker disease phenotype : comparison with similar cases from the literature .
21120616	0	PRNP	40,44	prion_protein	20,33	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism of the prion_protein gene -LRB- PRNP -RRB- in two Chinese indigenous cattle breeds .
22170597	0	PRNP	40,44	prion_protein	20,33	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism of the prion_protein gene -LRB- PRNP -RRB- in Polish cattle affected by classical bovine_spongiform_encephalopathy .
22412936	0	PRNP	69,73	prion_protein	49,62	PRNP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The 5 ' flanking region and intron1 of the bovine prion_protein gene -LRB- PRNP -RRB- are responsible for negative feedback regulation of the prion_protein .
23497519	0	PRNP	37,41	prion_protein	42,55	PRNP	prion protein	5621	5621	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Endoplasmic reticulum stress induces PRNP prion_protein gene expression in breast_cancer .
24287918	0	PRNP	34,38	prion_protein	39,52	PRNP	prion protein	5621	5621	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Up-regulation of mRNA ventricular PRNP prion_protein gene expression in air pollution highly exposed young urbanites : endoplasmic reticulum stress , glucose regulated protein 78 , and nanosized particles .
7485229	0	PRNP	62,66	prion_protein	42,55	PRNP	prion protein	5621	5621	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	SSCP analysis and sequencing of the human prion_protein gene -LRB- PRNP -RRB- detects two different 24 bp deletions in an atypical Alzheimer 's _ disease family .
7999319	0	PRNP	123,127	prion_protein	129,142	PRNP	prion protein	5621	5621	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	A novel mechanism of phenotypic heterogeneity demonstrated by the effect of a polymorphism on a pathogenic mutation in the PRNP -LRB- prion_protein gene -RRB- .
12623063	0	PRNP	41,45	prion_protein-encoding	17,39	PRNP	prion protein-encoding	5621	5621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Stability of the prion_protein-encoding -LRB- PRNP -RRB- gene in HeLa cells .
11140943	0	PROC	73,77	protein_C	62,71	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of an intronic regulatory element in the human protein_C -LRB- PROC -RRB- gene .
1511988	0	PROC	55,59	protein_C	44,53	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel homozygous missense mutation in the protein_C -LRB- PROC -RRB- gene causing recurrent venous_thrombosis .
1511989	0	PROC	62,66	protein_C	51,60	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two different missense mutations at Arg 178 of the protein_C -LRB- PROC -RRB- gene causing recurrent venous_thrombosis .
24115609	0	PROC	36,40	protein_C	20,29	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in protein_C gene -LRB- PROC -RRB- causing severe phenotype in neonatal period .
3356168	0	PROC	40,44	protein_C	24,33	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human protein_C gene -LRB- PROC -RRB- to chromosome region 2q14 -- q21 by in situ hybridization .
7605880	0	PROC	40,44	protein_C	29,38	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Three novel mutations in the protein_C -LRB- PROC -RRB- gene causing venous_thrombosis .
7841323	0	PROC	59,63	protein_C	48,57	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A homozygous deletion/insertion mutation in the protein_C -LRB- PROC -RRB- gene causing neonatal Purpura fulminans : prenatal diagnosis in an at-risk pregnancy .
8462980	0	PROC	44,48	protein_C	33,42	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel nonsense mutation in the protein_C -LRB- PROC -RRB- gene -LRB- Trp-29 -- > term -RRB- causing recurrent venous_thrombosis .
8499568	0	PROC	55,59	protein_C	44,53	PROC	protein C	5624	5624	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A Gla domain mutation -LRB- Arg_15 -- > Trp -RRB- in the protein_C -LRB- PROC -RRB- gene causing type 2 protein_C_deficiency and recurrent venous_thrombosis .
26052961	0	PROGRAMMED_DEATH_1	14,32	CD4	47,50	PROGRAMMED DEATH 1	CD4	5133	404704(Tax:9823)	Gene	Gene	EXPRESSION|compound|START_ENTITY EXPRESSION|nmod|CELLS CELLS|compound|END_ENTITY	PERIOPERATIVE PROGRAMMED_DEATH_1 EXPRESSION ON CD4 + T CELLS PREDICTS THE INCIDENCE OF POSTOPERATIVE INFECTIOUS COMPLICATIONS .
21098624	0	PROK1	35,40	CTGF	0,4	PROK1	CTGF	84432	1490	Gene	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubj|expression expression|compound|END_ENTITY	CTGF expression is up-regulated by PROK1 in early pregnancy and influences HTR-8 / Svneo cell adhesion and network formation .
26261540	0	PROM1	18,23	CD133	25,30	PROM1	CD133	8842	8842	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of PROM1 -LRB- CD133 -RRB- confers poor prognosis in non-small_cell_lung_cancer .
10773688	0	PROP1	75,80	Prop-1	62,68	PROP1	Prop-1	474647(Tax:9615)	474647(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning , characterization , and physical mapping of the canine Prop-1 gene -LRB- PROP1 -RRB- : exclusion as a candidate for combined_pituitary_hormone_deficiency in German shepherd dogs .
19442651	0	PROP1	0,5	SOX2	20,24	PROP1	SOX2	5626	6657	Gene	Gene	coexists|nsubj|START_ENTITY coexists|nmod|END_ENTITY	PROP1 coexists with SOX2 and induces PIT1-commitment cells .
16384867	0	PROP1	25,30	prophet_of_Pit1	8,23	PROP1	prophet of Pit1	19127(Tax:10090)	19127(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of prophet_of_Pit1 -LRB- PROP1 -RRB- in gonadotrope differentiation and puberty .
7579448	0	PROS1	56,61	protein_S_alpha	39,54	PROS1	protein S alpha	5627	5627	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Ser_460_to_Pro substitution of the protein_S_alpha -LRB- PROS1 -RRB- gene is a frequent mutation associated with free protein S -LRB- type IIa -RRB- deficiency .
10496079	0	PROSC	48,53	proline_synthetase_co-transcribed	55,88	PROSC	proline synthetase co-transcribed	114863(Tax:10090)	114863(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Cloning and characterization of human and mouse PROSC -LRB- proline_synthetase_co-transcribed -RRB- genes .
23840657	0	PRP	46,49	HGF	0,3	PRP	HGF	19131(Tax:10090)	15234(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	HGF mediates the anti-inflammatory effects of PRP on injured tendons .
1550127	0	PRP	100,103	proline-rich_protein	78,98	PRP	proline-rich protein	722	722	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	PRB2/1 fusion gene : a product of unequal and homologous crossing-over between proline-rich_protein -LRB- PRP -RRB- genes PRB1 and PRB2 .
20599946	0	PRP19	6,11	PHD3	46,50	PRP19	PHD3	27339	112399	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human PRP19 interacts with prolyl-hydroxylase PHD3 and inhibits cell death in hypoxia .
18729217	0	PRP28	70,75	DDX-23	27,33	PRP28	DDX-23	851830(Tax:4932)	175818(Tax:6239)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	The Caenorhabditis_elegans DDX-23 , a homolog of yeast splicing factor PRP28 , is required for the sperm-oocyte switch and differentiation of various cell types .
2154681	0	PRP4	4,8	RNA4	10,14	PRP4	RNA4	856307(Tax:4932)	856307(Tax:4932)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The PRP4 -LRB- RNA4 -RRB- protein of Saccharomyces_cerevisiae is associated with the 5 ' portion of the U4 small nuclear RNA .
20363051	0	PRPH	25,29	peripherin	8,18	PRPH	peripherin	5630	5630	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A novel peripherin gene -LRB- PRPH -RRB- mutation identified in one sporadic amyotrophic_lateral_sclerosis patient .
7806235	0	PRPH	44,48	peripherin	27,37	PRPH	peripherin	5630	5630	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The structure of the human peripherin gene -LRB- PRPH -RRB- and identification of potential regulatory elements .
17712528	0	PRPK	82,86	Akt/PKB	91,98	PRPK	Akt/PKB	112858	207	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of the atypical kinase p53-related_protein_kinase -LRB- PRPK -RRB- by Akt/PKB .
17712528	0	PRPK	82,86	p53-related_protein_kinase	54,80	PRPK	p53-related protein kinase	112858	112858	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of the atypical kinase p53-related_protein_kinase -LRB- PRPK -RRB- by Akt/PKB .
18986377	0	PRSS1	80,85	GSTM1	49,54	PRSS1	GSTM1	5644	2944	Gene	Gene	PSTI|appos|START_ENTITY PSTI|compound|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
18986377	0	PRSS1	80,85	GSTT1	56,61	PRSS1	GSTT1	5644	2952	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
18986377	0	PRSS1	80,85	LPL	75,78	PRSS1	LPL	5644	4023	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
18986377	0	PRSS1	80,85	NAT2	69,73	PRSS1	NAT2	5644	10	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
18986377	0	PRSS1	80,85	NQO1	63,67	PRSS1	NQO1	5644	1728	Gene	Gene	PSTI|appos|START_ENTITY PSTI|appos|END_ENTITY	Association analyses of genetic polymorphisms of GSTM1 , GSTT1 , NQO1 , NAT2 , LPL , PRSS1 , PSTI , and CFTR with chronic alcoholic_pancreatitis in Japan .
22699143	0	PRSS1	45,50	SPINK1	81,87	PRSS1	SPINK1	5644	6690	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis .
11708864	0	PRSS1	116,121	cationic_trypsinogen	89,109	PRSS1	cationic trypsinogen	5644	5644	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of a novel pancreatitis-associated missense mutation , R116C , in the human cationic_trypsinogen gene -LRB- PRSS1 -RRB- .
12765848	0	PRSS1	63,68	cationic_trypsinogen	36,56	PRSS1	cationic trypsinogen	5644	5644	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	`` Loss of function '' mutations in the cationic_trypsinogen gene -LRB- PRSS1 -RRB- may act as a protective factor against pancreatitis .
12939655	0	PRSS1	116,121	cationic_trypsinogen	94,114	PRSS1	cationic trypsinogen	5644	5644	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation analysis of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene , the cationic_trypsinogen -LRB- PRSS1 -RRB- gene , and the serine_protease_inhibitor , _ Kazal_type_1 -LRB- SPINK1 -RRB- gene in patients with alcoholic_chronic_pancreatitis .
19454815	0	PRSS1	131,136	cationic_trypsinogen	104,124	PRSS1	cationic trypsinogen	5644	5644	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hereditary_pancreatitis : clinical features and inheritance characteristics of the R122C mutation in the cationic_trypsinogen gene -LRB- PRSS1 -RRB- in six Spanish families .
10095086	0	PRSS12	42,48	serine_protease	16,31	PRSS12	serine protease	19142(Tax:10090)	50908(Tax:10090)	Gene	Gene	motopsin|nummod|START_ENTITY END_ENTITY|appos|motopsin	Expression of a serine_protease -LRB- motopsin PRSS12 -RRB- mRNA in the mouse brain : in situ hybridization histochemical study .
16756256	0	PRSS12	67,73	serine_protease	40,55	PRSS12	serine protease	19142(Tax:10090)	50908(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of a motoneuron-specific serine_protease , motopsin -LRB- PRSS12 -RRB- , after facial_nerve_axotomy in mice .
22384243	0	PRSS16	67,73	ZNF804a	0,7	PRSS16	ZNF804a	364719(Tax:10116)	295695(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ZNF804a regulates expression of the schizophrenia-associated genes PRSS16 , COMT , PDE4B , and DRD2 .
19052022	0	PRSS2	63,68	anionic_trypsinogen	42,61	PRSS2	anionic trypsinogen	5645	5645	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A loss-of-function p.G191R variant in the anionic_trypsinogen -LRB- PRSS2 -RRB- gene in Japanese patients with pancreatic_disorders .
15701722	0	PRSS22	119,125	Urokinase-type_plasminogen_activator	0,36	PRSS22	Urokinase-type plasminogen activator	64063	5328	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Urokinase-type_plasminogen_activator is a preferred substrate of the human epithelium serine protease tryptase_epsilon / PRSS22 .
22291950	0	PRSS23	16,22	estrogen_receptor_a	41,60	PRSS23	estrogen receptor a	11098	2099	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Serine_protease PRSS23 is upregulated by estrogen_receptor_a and associated with proliferation of breast_cancer cells .
10974542	0	PRSS6	10,15	KLK7	4,8	PRSS6	KLK7	5650	5650	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The KLK7 -LRB- PRSS6 -RRB- gene , encoding for the stratum_corneum_chymotryptic_enzyme is a new member of the human kallikrein gene family - genomic characterization , mapping , tissue expression and hormonal regulation .
27050145	0	PRSS8	17,22	Akt	47,50	PRSS8	Akt	76560(Tax:10090)	11651(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3 / Akt signaling in colorectal_cancer .
10600542	0	PRSS_21	35,42	esp-1	23,28	PRSS 21	esp-1	10942	10942	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural analysis of esp-1 gene -LRB- PRSS_21 -RRB- .
8629812	0	PRTN3	18,23	proteinase_3	4,16	PRTN3	proteinase 3	5657	5657	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The proteinase_3 -LRB- PRTN3 -RRB- gene is localized on 19p13 .3 and is distal to the E2A gene .
25501702	0	PR_domain_containing_5	17,39	PRDM5	41,46	PR domain containing 5	PRDM5	11107	11107	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Emerging role of PR_domain_containing_5 -LRB- PRDM5 -RRB- as a broad tumor suppressor in human cancers .
21179780	0	PS-1	39,43	Abeta	62,67	PS-1	Abeta	29192(Tax:10116)	54226(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of vitamin_E on expression of PS-1 and production of Abeta in the hippocampus of female senile rats -RSB- .
8873134	0	PS-1	40,44	presenilin-1	26,38	PS-1	presenilin-1	5663	5663	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of Alzheimer 's presenilin-1 -LRB- PS-1 -RRB- gene to 14q24 .3 by fluorescence in situ hybridization .
9667772	0	PS-1	46,50	presenilin_1	32,44	PS-1	presenilin 1	5663	5663	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Lack of specific association of presenilin_1 -LRB- PS-1 -RRB- protein with plaques and tangles in Alzheimer 's _ disease .
9121700	0	PS-2	40,44	presenilin-2	26,38	PS-2	presenilin-2	5664	5664	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of Alzheimer 's presenilin-2 -LRB- PS-2 -RRB- gene to 1q42 .1 by fluorescence in situ hybridization .
15471851	0	PS-GAP	39,45	PAK-2	88,93	PS-GAP	PAK-2	79658	5062	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2 .
25750298	0	PS-PLA1	46,53	Phosphatidylserine-specific_Phospholipase_A1	0,44	PS-PLA1	Phosphatidylserine-specific Phospholipase A1	51365	51365	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Phosphatidylserine-specific_Phospholipase_A1 -LRB- PS-PLA1 -RRB- Expression in Colorectal_Cancer Correlates with Tumor Invasion and Hematogenous_Metastasis .
22418058	0	PS1	74,77	APP	65,68	PS1	APP	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	The effect of ageing on neurogenesis and oxidative stress in the APP -LRB- swe -RRB- / PS1 -LRB- deltaE9 -RRB- mouse model of Alzheimer 's _ disease .
10069390	1	PS1	89,92	presenilin-1	75,87	PS1	presenilin-1	5663	5663	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Five presenilin-1 -LRB- PS1 -RRB- mutations do not alter the sensitivity of PS1 to caspases .
11129109	0	PS1	37,40	presenilin_1	23,35	PS1	presenilin 1	5663	5663	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	No association between presenilin_1 -LRB- PS1 -RRB- intronic polymorphism and sporadic Alzheimer 's _ disease in Koreans .
16300890	0	PS1	73,76	presenilin_1	59,71	PS1	presenilin 1	29192(Tax:10116)	29192(Tax:10116)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Calcium oscillations in type-1 astrocytes , the effect of a presenilin_1 -LRB- PS1 -RRB- mutation .
19181896	0	PS1	26,29	presenilin_1	12,24	PS1	presenilin 1	19164(Tax:10090)	19164(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increase in presenilin_1 -LRB- PS1 -RRB- levels in senescence-accelerated mice -LRB- SAMP8 -RRB- may indirectly impair memory by affecting amyloid_precursor_protein -LRB- APP -RRB- processing .
8922407	0	PS1	34,37	presenilin_1_and_2	14,32	PS1	presenilin 1 and 2	5663	5663;5664	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of presenilin_1_and_2 -LRB- PS1 and PS2 -RRB- in human and murine tissues .
11201091	0	PS2	14,17	Presenilin-2	0,12	PS2	Presenilin-2	81751(Tax:10116)	81751(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Presenilin-2 -LRB- PS2 -RRB- expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis .
2940234	0	PS3	75,78	ATPase	38,44	PS3	ATPase	448990	1769	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Spectroscopic characterization of the ATPase of the thermophilic bacterium PS3 and its isolated subunits .
19414393	0	PSA	22,25	ARE-I	0,5	PSA	ARE-I	354	1475	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|amod|END_ENTITY	ARE-I polymorphism on PSA gene in prostate_cancer patients of a Turkish population .
10547578	0	PSA	54,57	Androgen_receptor	0,17	PSA	Androgen receptor	354	367	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|amplification amplification|amod|END_ENTITY	Androgen_receptor gene amplification increases tissue PSA protein expression in hormone-refractory prostate_carcinoma .
19483644	0	PSA	142,145	CD8	100,103	PSA	CD8	354	925	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Vaccination with agonist peptide PSA : 154-163 -LRB- 155L -RRB- derived from prostate_specific_antigen induced CD8 T-cell response to the native peptide PSA : 154-163 but failed to induce the reactivity against tumor targets expressing PSA : a phase 2 study in patients with recurrent prostate_cancer .
19483644	0	PSA	224,227	CD8	100,103	PSA	CD8	354	925	Gene	Gene	expressing|dobj|START_ENTITY targets|acl|expressing induce|nmod|targets failed|xcomp|induce 154-163|acl|failed response|dep|154-163 response|compound|END_ENTITY	Vaccination with agonist peptide PSA : 154-163 -LRB- 155L -RRB- derived from prostate_specific_antigen induced CD8 T-cell response to the native peptide PSA : 154-163 but failed to induce the reactivity against tumor targets expressing PSA : a phase 2 study in patients with recurrent prostate_cancer .
19483644	0	PSA	33,36	CD8	100,103	PSA	CD8	354	925	Gene	Gene	Vaccination|nmod|START_ENTITY Vaccination|dep|154-163 154-163|acl|derived derived|nmod|prostate_specific_antigen prostate_specific_antigen|acl|induced induced|dobj|response response|compound|END_ENTITY	Vaccination with agonist peptide PSA : 154-163 -LRB- 155L -RRB- derived from prostate_specific_antigen induced CD8 T-cell response to the native peptide PSA : 154-163 but failed to induce the reactivity against tumor targets expressing PSA : a phase 2 study in patients with recurrent prostate_cancer .
10510914	0	PSA	63,66	IGF-1	30,35	PSA	IGF-1	354	3479	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- , IGF-1 density , and IGF-1 / PSA ratio for prostate_cancer detection .
12350485	0	PSA	0,3	PSA	58,61	PSA	PSA	354	354	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nsubj|response	PSA response to finasteride challenge in men with a serum PSA greater than 4 ng/ml and previous negative prostate biopsy : preliminary study .
12350485	0	PSA	58,61	PSA	0,3	PSA	PSA	354	354	Gene	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	PSA response to finasteride challenge in men with a serum PSA greater than 4 ng/ml and previous negative prostate biopsy : preliminary study .
8659274	0	PSA	14,17	PSA	25,28	PSA	PSA	9520	9520	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	-LSB- The index of PSA age vs PSA density .
8659274	0	PSA	25,28	PSA	14,17	PSA	PSA	9520	9520	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	-LSB- The index of PSA age vs PSA density .
9111601	0	PSA	101,104	PSA	82,85	PSA	PSA	354	354	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Improvement of prostate_cancer screening by determination of the ratio free/total PSA in addition to PSA levels .
9111601	0	PSA	82,85	PSA	101,104	PSA	PSA	354	354	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Improvement of prostate_cancer screening by determination of the ratio free/total PSA in addition to PSA levels .
20414405	0	PSA	100,103	Prostate-Specific_Antigen	73,98	PSA	Prostate-Specific Antigen	354	354	Gene	Gene	Levels|appos|START_ENTITY Levels|compound|END_ENTITY	Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific_Antigen -LRB- PSA -RRB- Levels .
21221201	0	PSA	63,66	Prostate-Specific_Antigen	36,61	PSA	Prostate-Specific Antigen	354	354	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Association of Polymorphisms in the Prostate-Specific_Antigen -LRB- PSA -RRB- Gene Promoter with Serum PSA Level and PSA Changes after Dutasteride Treatment in Korean Men with Benign_Prostatic_Hypertrophy .
25621688	0	PSA	77,80	Prostate-Specific_Antigen	50,75	PSA	Prostate-Specific Antigen	354	354	Gene	Gene	Levels|appos|START_ENTITY Levels|compound|END_ENTITY	The Effect of Testosterone Replacement Therapy on Prostate-Specific_Antigen -LRB- PSA -RRB- Levels in Men Being Treated for Hypogonadism : A Systematic Review and Meta-Analysis .
12746846	0	PSA	27,30	Prostate-specific_antigen	0,25	PSA	Prostate-specific antigen	354	354	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Prostate-specific_antigen -LRB- PSA -RRB- protein does not affect growth of prostate_cancer cells in vitro or prostate_cancer xenografts in vivo .
16140973	0	PSA	141,144	androgen_receptor	106,123	PSA	androgen receptor	354	367	Gene	Gene	locus|compound|START_ENTITY occupancy|nmod|locus occupancy|compound|END_ENTITY	Androgen_receptor-dependent PSA expression in androgen-independent prostate_cancer cells does not involve androgen_receptor occupancy of the PSA locus .
16140973	0	PSA	28,31	androgen_receptor	106,123	PSA	androgen receptor	354	367	Gene	Gene	expression|compound|START_ENTITY involve|nsubj|expression involve|dobj|occupancy occupancy|compound|END_ENTITY	Androgen_receptor-dependent PSA expression in androgen-independent prostate_cancer cells does not involve androgen_receptor occupancy of the PSA locus .
19575420	0	PSA	182,185	androgen_receptor	43,60	PSA	androgen receptor	354	367	Gene	Gene	surrogacy|compound|START_ENTITY implications|nmod|surrogacy lines|dep|implications lines|compound|expression expression|nmod|END_ENTITY	Docetaxel down-regulates the expression of androgen_receptor and prostate-specific_antigen but not prostate-specific_membrane_antigen in prostate_cancer cell lines : implications for PSA surrogacy .
21956655	0	PSA	0,3	androgen_receptor	14,31	PSA	androgen receptor	354	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PSA regulates androgen_receptor expression in prostate_cancer cells .
24820830	0	PSA	111,114	androgen_receptor	73,90	PSA	androgen receptor	354	367	Gene	Gene	levels|compound|START_ENTITY serum|dobj|levels _|advcl|serum _|dobj|genes genes|amod|END_ENTITY	Contribution of allelic variability in prostate_specific_antigen -LRB- PSA -RRB- _ androgen_receptor -LRB- AR -RRB- genes to serum PSA levels in men with prostate_cancer .
24820830	0	PSA	66,69	androgen_receptor	73,90	PSA	androgen receptor	354	367	Gene	Gene	Contribution|appos|START_ENTITY _|nsubj|Contribution _|dobj|genes genes|amod|END_ENTITY	Contribution of allelic variability in prostate_specific_antigen -LRB- PSA -RRB- _ androgen_receptor -LRB- AR -RRB- genes to serum PSA levels in men with prostate_cancer .
9044850	0	PSA	199,202	androgen_receptor	119,136	PSA	androgen receptor	354	367	Gene	Gene	gene|compound|START_ENTITY Down-regulation|nmod|gene Down-regulation|nmod|END_ENTITY	Down-regulation of prostate-specific_antigen expression by finasteride through inhibition of complex formation between androgen_receptor and steroid_receptor-binding_consensus in the promoter of the PSA gene in LNCaP cells .
10070886	0	PSA	41,44	prostate-specific_antigen	14,39	PSA	prostate-specific antigen	354	354	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of prostate-specific_antigen -LRB- PSA -RRB- correlates with poor response to tamoxifen therapy in recurrent breast_cancer .
10486959	0	PSA	41,44	prostate-specific_antigen	14,39	PSA	prostate-specific antigen	354	354	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of prostate-specific_antigen -LRB- PSA -RRB- membrane test assays for the forensic identification of seminal fluid .
11561687	0	PSA	38,41	prostate-specific_antigen	11,36	PSA	prostate-specific antigen	354	354	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Changes in prostate-specific_antigen -LRB- PSA -RRB- level correlate with growth inhibition of prostate_cancer cells treated in vitro with a novel anticancer drug , irofulven .
1379363	0	PSA	50,53	prostate-specific_antigen	23,48	PSA	prostate-specific antigen	354	354	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Hormonal regulation of prostate-specific_antigen -LRB- PSA -RRB- glycoprotein in the human prostatic_adenocarcinoma cell line , LNCaP .
14635070	0	PSA	114,117	prostate-specific_antigen	87,112	PSA	prostate-specific antigen	354	354	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Clinical features of patients who present with metastatic prostate_carcinoma and serum prostate-specific_antigen -LRB- PSA -RRB- levels < 10 ng/mL : the `` PSA negative '' patients .
18853950	0	PSA	54,57	prostate-specific_antigen	27,52	PSA	prostate-specific antigen	354	354	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The effect of sirolimus on prostate-specific_antigen -LRB- PSA -RRB- levels in male_renal_transplant_recipients_without_prostate_cancer .
22093091	0	PSA	110,113	prostate-specific_antigen	83,108	PSA	prostate-specific antigen	354	354	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Transperineal prostate biopsy detects significant cancer in patients with elevated prostate-specific_antigen _ -LRB- PSA -RRB- levels and previous negative transrectal biopsies .
22093144	0	PSA	36,39	prostate-specific_antigen	9,34	PSA	prostate-specific antigen	354	354	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Value of prostate-specific_antigen -LRB- PSA -RRB- mass ratio in the detection of prostate_cancer in men with PSA levels of < = 10 ng/mL .
8758241	0	PSA	9,12	prostate-specific_antigen	14,39	PSA	prostate-specific antigen	354	354	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	Value of PSA -LRB- prostate-specific_antigen -RRB- in the detection of prostate_cancer in patients with urological symptoms .
11229650	0	PSA	52,55	prostate_specific_antigen	25,50	PSA	prostate specific antigen	354	354	Gene	Gene	increase|appos|START_ENTITY increase|amod|END_ENTITY	Tibia metastasis without prostate_specific_antigen -LRB- PSA -RRB- increase following radical vesiculo-prostatectomy .
11791186	0	PSA	41,44	prostate_specific_antigen	14,39	PSA	prostate specific antigen	354	354	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of prostate_specific_antigen -LRB- PSA -RRB- is negatively regulated by p53 .
15678849	0	PSA	61,64	prostate_specific_antigen	34,59	PSA	prostate specific antigen	354	354	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of prostate_specific_antigen -LRB- PSA -RRB- in benign and malignant_tumors of the prostate .
15751649	0	PSA	107,110	prostate_specific_antigen	80,105	PSA	prostate specific antigen	354	354	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Tumor markers in prostate_cancer -- clinical significance and future prospect of prostate_specific_antigen -LRB- PSA -RRB- -RSB- .
24573892	0	PSA	36,39	prostate_specific_antigen	9,34	PSA	prostate specific antigen	354	354	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Elevated prostate_specific_antigen -LRB- PSA -RRB- levels a risk factor for pathological hip_fracture in metastatic prostatic_carcinoma .
26506115	0	PSA	46,49	prostate_specific_antigen	19,44	PSA	prostate specific antigen	354	354	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	Clinical impact of prostate_specific_antigen -LRB- PSA -RRB- inter-assay variability on management of prostate_cancer .
7685140	0	PSA	49,52	prostate_specific_antigen	22,47	PSA	prostate specific antigen	354	354	Gene	Gene	Examination|appos|START_ENTITY Examination|nmod|END_ENTITY	-LSB- Examination of serum prostate_specific_antigen -LRB- PSA -RRB- in the mass screening for prostatic_diseases -RSB- .
9125863	0	PSA	101,104	prostate_specific_antigen	74,99	PSA	prostate specific antigen	354	354	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- A pilot study of mass screening program for prostatic_cancer by means of prostate_specific_antigen -LRB- PSA -RRB- filter paper method -RSB- .
9250498	0	PSA	86,89	prostate_specific_antigen	59,84	PSA	prostate specific antigen	354	354	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Diagnosis and follow-up of prostate_cancer patients using prostate_specific_antigen -LRB- PSA -RRB- -RSB- .
9772877	0	PSA	69,72	prostate_specific_antigen	13,38	PSA	prostate specific antigen	354	354	Gene	Gene	ratio|compound|START_ENTITY value|dep|ratio value|nmod|END_ENTITY	The value of prostate_specific_antigen -LRB- PSA -RRB- density and free : total PSA ratio in selecting patients with a normal digital rectal examination and intermediate total PSA levels for further investigation .
9872328	0	PSA	75,78	prostate_specific_antigen	48,73	PSA	prostate specific antigen	354	354	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Molecular and immunological analysis of genetic prostate_specific_antigen -LRB- PSA -RRB- vaccine .
23207240	0	PSAP	0,4	Apaf-1	22,28	PSAP	Apaf-1	23787	317	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins .
26692143	0	PSAP	140,144	MTCH_1	99,105	PSAP	MTCH 1	5660	23787	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Early_growth_response_1 -LRB- EGR-1 -RRB- is a transcriptional regulator of mitochondrial_carrier_homolog_1 -LRB- MTCH_1 -RRB- / presenilin_1-associated protein -LRB- PSAP -RRB- .
26692143	0	PSAP	140,144	mitochondrial_carrier_homolog_1	66,97	PSAP	mitochondrial carrier homolog 1	5660	23787	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Early_growth_response_1 -LRB- EGR-1 -RRB- is a transcriptional regulator of mitochondrial_carrier_homolog_1 -LRB- MTCH_1 -RRB- / presenilin_1-associated protein -LRB- PSAP -RRB- .
8641138	0	PSAP	41,45	prosaposin	24,34	PSAP	prosaposin	5660	5660	Gene	Gene	Assignment|appos|START_ENTITY Assignment|nmod|gene gene|compound|END_ENTITY	Assignment of the human prosaposin gene -LRB- PSAP -RRB- to 10q22 .1 by fluorescence in situ hybridization .
15342669	0	PSCA	28,32	Prostate_stem_cell_antigen	0,26	PSCA	Prostate stem cell antigen	8000	8000	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prostate_stem_cell_antigen -LRB- PSCA -RRB- expression in human prostate_cancer tissues : implications for prostate carcinogenesis and progression_of_prostate_cancer .
26147638	0	PSCA	47,51	Slug	56,60	PSCA	Slug	8000	6591	Gene	Gene	antigen|appos|START_ENTITY antigen|nmod|END_ENTITY	Down-regulation of prostate stem cell antigen -LRB- PSCA -RRB- by Slug promotes metastasis in nasopharyngeal_carcinoma .
18076024	0	PSCA	47,51	prostate_stem_cell_antigen	19,45	PSCA	prostate stem cell antigen	8000	8000	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association of prostate_stem_cell_antigen -LRB- PSCA -RRB- mRNA expression and subsequent prostate_cancer risk in men with benign_prostatic_hyperplasia following transurethral resection of the prostate .
10363132	0	PSCD3	36,41	ARNO3	24,29	PSCD3	ARNO3	9265	9265	Gene	Gene	Assignment|appos|START_ENTITY Assignment|nmod|gene gene|compound|END_ENTITY	Assignment of the human ARNO3 gene -LRB- PSCD3 -RRB- to chromosome 7p21 by radiation hybrid mapping .
18579798	0	PSD-95	75,81	Acid-sensing_ion_channel_3	0,26	PSD-95	Acid-sensing ion channel 3	1742	9311	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	Acid-sensing_ion_channel_3 -LRB- ASIC3 -RRB- cell surface expression is modulated by PSD-95 within lipid rafts .
26898829	0	PSD-95	0,6	CRFR1	17,22	PSD-95	CRFR1	1742	1394	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nummod|END_ENTITY	PSD-95 regulates CRFR1 localization , trafficking and b-arrestin2 recruitment .
8755482	0	PSD-95	92,98	Chapsyn-110	63,74	PSD-95	Chapsyn-110	29495(Tax:10116)	64053(Tax:10116)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110 , a member of the PSD-95 family of proteins .
12390249	0	PSD-95	41,47	Densin-180	0,10	PSD-95	Densin-180	1742	57554	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	Densin-180 , a synaptic protein , links to PSD-95 through its direct interaction with MAGUIN-1 .
11278603	0	PSD-95	70,76	ERBIN	54,59	PSD-95	ERBIN	1742	55914	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95 / DLG/ZO -1 domain proteins .
26505562	0	PSD-95	19,25	Ephrin-B3	0,9	PSD-95	Ephrin-B3	1742	1949	Gene	Gene	recruits|xcomp|START_ENTITY recruits|nsubj|END_ENTITY	Ephrin-B3 recruits PSD-95 to synapses .
11279080	0	PSD-95	78,84	Erbin	0,5	PSD-95	Erbin	1742	55914	Gene	Gene	interacts|nmod|START_ENTITY membranes|acl:relcl|interacts concentrated|nmod|membranes protein|acl|concentrated protein|nsubj|END_ENTITY	Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95 .
16271045	0	PSD-95	24,30	GLYT1	70,75	PSD-95	GLYT1	29495(Tax:10116)	116509(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The scaffolding protein PSD-95 interacts with the glycine transporter GLYT1 and impairs its internalization .
11700307	0	PSD-95	90,96	G_protein-coupled_receptor_kinase_5	0,35	PSD-95	G protein-coupled receptor kinase 5	1742	2869	Gene	Gene	association|nmod|START_ENTITY regulates|dobj|association regulates|nsubj|END_ENTITY	G_protein-coupled_receptor_kinase_5 regulates beta 1-adrenergic receptor association with PSD-95 .
15255944	0	PSD-95	65,71	Insulin_receptor_substrate_of_53_kDa	0,36	PSD-95	Insulin receptor substrate of 53 kDa	1742	10458	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	Insulin_receptor_substrate_of_53_kDa links postsynaptic shank to PSD-95 .
20410104	0	PSD-95	56,62	MTMR2	35,40	PSD-95	MTMR2	1742	8898	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The phosphoinositide 3-phosphatase MTMR2 interacts with PSD-95 and maintains excitatory synapses by modulating endosomal traffic .
23183381	0	PSD-95	0,6	NBCn1	22,27	PSD-95	NBCn1	1742	9497	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PSD-95 interacts with NBCn1 and enhances channel-like activity without affecting Na/HCO -LRB- 3 -RRB- _ cotransport .
25590984	0	PSD-95	118,124	Postsynaptic_Density-95	93,116	PSD-95	Postsynaptic Density-95	116681(Tax:10116)	116681(Tax:10116)	Gene	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Design , Synthesis , and Characterization of Fatty_Acid Derivatives of a Dimeric Peptide-Based Postsynaptic_Density-95 -LRB- PSD-95 -RRB- Inhibitor .
10521598	0	PSD-95	58,64	SAP90	65,70	PSD-95	SAP90	1742	1742	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95 / SAP90 family .
10627592	0	PSD-95	88,94	SAP90	95,100	PSD-95	SAP90	1742	1742	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Neuronal inwardly rectifying K -LRB- + -RRB- channels differentially couple to PDZ proteins of the PSD-95 / SAP90 family .
9581761	0	PSD-95	51,57	SAP90	58,63	PSD-95	SAP90	1742	1742	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	SynGAP : a synaptic RasGAP that associates with the PSD-95 / SAP90 protein family .
12576483	0	PSD-95	121,127	Src	95,98	PSD-95	Src	13385(Tax:10090)	20779(Tax:10090)	Gene	Gene	domains|nmod|START_ENTITY homology|dobj|domains homology|nsubj|Interaction Interaction|nmod|Pyk2 Pyk2|nmod|complex complex|nmod|END_ENTITY	Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 .
12618293	0	PSD-95	140,146	Src	116,119	PSD-95	Src	29495(Tax:10116)	83805(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY 2A|acl|mediated 2A|nmod|END_ENTITY	Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain_ischemia .
16990796	0	PSD-95	0,6	Src	54,57	PSD-95	Src	1742	6714	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex .
20197063	0	PSD-95	26,32	Src	43,46	PSD-95	Src	29495(Tax:10116)	83805(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS -LRB- Ser847 -RRB- phosphorylation contributing to neuroprotection after cerebral_ischemia .
9756850	0	PSD-95	78,84	brain-enriched_guanylate_kinase-associated_protein	8,58	PSD-95	brain-enriched guanylate kinase-associated protein	1742	57596	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	BEGAIN -LRB- brain-enriched_guanylate_kinase-associated_protein -RRB- , a novel neuronal PSD-95 / SAP90-binding protein .
15494726	0	PSD-95	47,53	neuregulin-1_and_Eos	57,77	PSD-95	neuregulin-1 and Eos	13385(Tax:10090)	211323;22781	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Activity-dependent transcription regulation of PSD-95 by neuregulin-1_and_Eos .
21965656	0	PSD-95	126,132	postsynaptic_density-95	101,124	PSD-95	postsynaptic density-95	1742	1742	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Phosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in postsynaptic_density-95 -LRB- PSD-95 -RRB- protein , a membrane-associated guanylate kinase -LRB- MAGUK -RRB- .
3143303	0	PSE-1	114,119	TEM-1	154,159	PSE-1	TEM-1	13906560	2716540(Tax:562)	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Resistance to ticarcillin-potassium_clavulanate among clinical isolates of the family Enterobacteriaceae : role of PSE-1 beta-lactamase and high levels of TEM-1 and SHV-1 and problems with false susceptibility in disk diffusion tests .
22495347	0	PSEN1	91,96	AbPP	82,86	PSEN1	AbPP	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Chronic allopregnanolone treatment accelerates Alzheimer 's _ disease development in AbPP -LRB- Swe -RRB- PSEN1 -LRB- / \ E9 -RRB- mice .
26159201	0	PSEN1	10,15	MAPT	29,33	PSEN1	MAPT	5663	4137	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer 's _ disease .
10775535	0	PSEN1	53,58	presenilin-1	39,51	PSEN1	presenilin-1	5663	5663	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Alzheimer 's _ disease due to an intronic presenilin-1 -LRB- PSEN1 intron 4 -RRB- mutation : A clinicopathological study .
9073509	0	PSEN1	99,104	presenilin-1	80,92	PSEN1	presenilin-1	5663	5663	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the 5 ' sequence , genomic structure , and alternative splicing of the presenilin-1 gene -LRB- PSEN1 -RRB- associated with early onset Alzheimer_disease .
12232783	0	PSEN2	57,62	presenilin-2	43,55	PSEN2	presenilin-2	5664	5664	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulatory region variability in the human presenilin-2 -LRB- PSEN2 -RRB- gene : potential contribution to the gene activity and risk for AD .
18087668	0	PSEN2	40,45	presenilin-2	21,33	PSEN2	presenilin-2	5664	5664	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two polymorphisms of presenilin-2 gene -LRB- PSEN2 -RRB- 5 ' regulatory region are not associated with Alzheimer 's _ disease -LRB- AD -RRB- in the Polish population .
19389484	0	PSF	175,178	HMGA1	118,123	PSF	HMGA1	71514(Tax:10090)	15361(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY END_ENTITY|appos|factor	Transcriptional activity of the murine retinol-binding_protein gene is regulated by a multiprotein complex containing HMGA1 , p54 nrb/NonO , protein-associated splicing factor -LRB- PSF -RRB- and steroidogenic_factor_1 -LRB- SF1 -RRB- / liver_receptor_homologue_1 -LRB- LRH-1 -RRB- .
19447914	0	PSF	6,9	RAD51	19,24	PSF	RAD51	3490	5888	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities .
20605917	0	PSF	42,45	hDlg	81,85	PSF	hDlg	6421	1739	Gene	Gene	interaction|nmod|START_ENTITY regulates|dobj|interaction regulates|nmod|END_ENTITY	p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock .
19874820	0	PSF	23,26	hnRNP_M	0,7	PSF	hnRNP M	6421	4670	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	hnRNP_M interacts with PSF and p54 -LRB- nrb -RRB- and co-localizes within defined nuclear structures .
9313760	0	PSF	62,65	prostacyclin-stimulating_factor	29,60	PSF	prostacyclin-stimulating factor	3490	3490	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of prostacyclin-stimulating_factor -LRB- PSF -RRB- in the diabetic and atherosclerotic human coronary artery .
23189151	0	PSF2	21,25	Snm1B	0,5	PSF2	Snm1B	51659	64858	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Snm1B interacts with PSF2 .
2306242	0	PSG	60,63	pregnancy_specific_beta_1_glycoprotein	20,58	PSG	pregnancy specific beta 1 glycoprotein	5673	5673	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Expression of human pregnancy_specific_beta_1_glycoprotein -LRB- PSG -RRB- genes during placental development .
16563348	0	PSG-5	56,61	KLF4	74,78	PSG-5	KLF4	5673	9314	Gene	Gene	promoter|compound|START_ENTITY Activation|nmod|promoter Activation|nmod|END_ENTITY	Activation of the human pregnancy-specific glycoprotein PSG-5 promoter by KLF4 and Sp1 .
15579466	0	PSGL-1	14,20	L-selectin	39,49	PSGL-1	L-selectin	6404	6402	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Regulation of PSGL-1 interactions with L-selectin , P-selectin , and E-selectin : role of human fucosyltransferase-IV_and _ - VII .
10770806	0	PSGL-1	34,40	P-Selectin	0,10	PSGL-1	P-Selectin	6404	6403	Gene	Gene	1|appos|START_ENTITY expressed|nsubjpass|1 ligand|ccomp|expressed ligand|nsubj|glycoprotein glycoprotein|amod|END_ENTITY	P-Selectin glycoprotein ligand 1 -LRB- PSGL-1 -RRB- is expressed on platelets and can mediate platelet-endothelial interactions in vivo .
11030527	0	PSGL-1	108,114	P-selectin	21,31	PSGL-1	P-selectin	6404	6403	Gene	Gene	concentrates|nmod|START_ENTITY concentrates|nsubj|Platelets Platelets|acl|expressing expressing|dobj|microparticles microparticles|amod|END_ENTITY	Platelets expressing P-selectin and platelet-derived microparticles in stored platelet concentrates bind to PSGL-1 on filtrated leukocytes .
11566773	0	PSGL-1	52,58	P-selectin	79,89	PSGL-1	P-selectin	6404	6403	Gene	Gene	adhesion|compound|START_ENTITY adhesion|nmod|END_ENTITY	Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin .
11916843	0	PSGL-1	14,20	P-selectin	89,99	PSGL-1	P-selectin	6404	6403	Gene	Gene	microbead|dep|START_ENTITY Comparison|nmod|microbead stabilizes|nsubj|Comparison stabilizes|dobj|clusters clusters|amod|END_ENTITY	Comparison of PSGL-1 microbead and neutrophil rolling : microvillus elongation stabilizes P-selectin bond clusters .
12036880	0	PSGL-1	18,24	P-selectin	108,118	PSGL-1	P-selectin	6404	6403	Gene	Gene	cytoplasmic|amod|START_ENTITY domain|amod|cytoplasmic Attachment|nmod|domain essential|nsubj|Attachment essential|xcomp|rolling rolling|nmod|END_ENTITY	Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin .
15653735	2	PSGL-1	140,146	P-selectin	111,121	PSGL-1	P-selectin	6404	6403	Gene	Gene	terminated|nmod|START_ENTITY terminated|nmod|dissociation dissociation|amod|END_ENTITY	Tether flow terminated by P-selectin dissociation from PSGL-1 .
16100264	0	PSGL-1	102,108	P-selectin	109,119	PSGL-1	P-selectin	6404	6403	Gene	Gene	lifetime|compound|START_ENTITY lifetime|compound|END_ENTITY	Neutrophil-bead collision assay : pharmacologically induced changes in membrane mechanics regulate the PSGL-1 / P-selectin adhesion lifetime .
16387772	0	PSGL-1	27,33	P-selectin	16,26	PSGL-1	P-selectin	6404	6403	Gene	Gene	bonds|compound|START_ENTITY bonds|amod|END_ENTITY	Biomechanics of P-selectin PSGL-1 bonds : shear threshold and integrin-independent cell adhesion .
17267403	0	PSGL-1	126,132	P-selectin	77,87	PSGL-1	P-selectin	6404	6403	Gene	Gene	interactions|appos|START_ENTITY interactions|amod|END_ENTITY	Impact of carrier stiffness and microtopology on two-dimensional kinetics of P-selectin and P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- interactions .
19262138	0	PSGL-1	23,29	P-selectin	0,10	PSGL-1	P-selectin	6404	6403	Gene	Gene	START_ENTITY|nsubj|cross-links cross-links|amod|END_ENTITY	P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent , but GPCR-independent mechanism .
19403178	0	PSGL-1	7,13	P-selectin	41,51	PSGL-1	P-selectin	6404	6403	Gene	Gene	modifications|compound|START_ENTITY required|nsubj|modifications required|nmod|END_ENTITY	Equine PSGL-1 modifications required for P-selectin binding .
19962723	0	PSGL-1	12,18	P-selectin	0,10	PSGL-1	P-selectin	6404	6403	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	P-selectin / PSGL-1 inhibitors versus enoxaparin in the resolution of venous_thrombosis : a meta-analysis .
21144558	0	PSGL-1	63,69	P-selectin	111,121	PSGL-1	P-selectin	6404	6403	Gene	Gene	carriers|nmod|START_ENTITY neutrophils|nmod|carriers differences|nmod|neutrophils differences|acl|immobilised immobilised|dobj|END_ENTITY	Phenotypic differences of human neutrophils of carriers of the PSGL-1 A and B-allele in binding to immobilised P-selectin under flow conditions .
25824568	0	PSGL-1	26,32	P-selectin	41,51	PSGL-1	P-selectin	6404	6403	Gene	Gene	analogues|nmod|START_ENTITY inhibit|nsubj|analogues inhibit|dobj|END_ENTITY	Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo .
7585949	0	PSGL-1	52,58	P-selectin	75,85	PSGL-1	P-selectin	6404	6403	Gene	Gene	terminus|nmod|START_ENTITY segment|nmod|terminus critical|nsubj|segment critical|nmod|END_ENTITY	A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding .
7585950	0	PSGL-1	0,6	P-selectin	22,32	PSGL-1	P-selectin	6404	6403	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus .
7585950	0	PSGL-1	88,94	P-selectin	22,32	PSGL-1	P-selectin	6404	6403	Gene	Gene	terminus|amod|START_ENTITY consensus|nmod|terminus controlled|nmod|consensus controlled|nsubjpass|recognition recognition|nmod|END_ENTITY	PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus .
7592904	0	PSGL-1	154,160	P-selectin	113,123	PSGL-1	P-selectin	6404	6403	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	A novel cobra venom metalloproteinase , mocarhagin , cleaves a 10-amino_acid peptide from the mature N terminus of P-selectin glycoprotein ligand receptor , PSGL-1 , and abolishes P-selectin binding .
9660879	0	PSGL-1	50,56	P-selectin	94,104	PSGL-1	P-selectin	6404	6403	Gene	Gene	P-selectin_glycoprotein_ligand-1|appos|START_ENTITY Dimerization|nmod|P-selectin_glycoprotein_ligand-1 required|nsubj|Dimerization required|nmod|recognition recognition|nmod|END_ENTITY	Dimerization of P-selectin_glycoprotein_ligand-1 -LRB- PSGL-1 -RRB- required for optimal recognition of P-selectin .
3128500	0	PSK	11,14	interleukin-2	18,31	PSK	interleukin-2	9344	3558	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of PSK on interleukin-2 production by peripheral lymphocytes of patients with advanced ovarian_carcinoma during chemotherapy .
24236444	0	PSK1	0,4	SOD1	29,33	PSK1	SOD1	851216(Tax:4932)	853568(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	PSK1 regulates expression of SOD1 involved in oxidative stress tolerance in yeast .
8595888	0	PSM	77,80	prostate-specific_membrane_antigen	41,75	PSM	prostate-specific membrane antigen	2346	2346	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization and physical mapping of the prostate-specific_membrane_antigen -LRB- PSM -RRB- gene to human chromosome 11 .
26862945	0	PSMA	36,40	Prostate-specific_Membrane_Antigen	0,34	PSMA	Prostate-specific Membrane Antigen	2346	2346	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Prostate-specific_Membrane_Antigen -LRB- PSMA -RRB- Expression in the Neovasculature of Gynecologic Malignancies : Implications for PSMA-targeted Therapy .
17448023	0	PSMA	36,40	Prostate-specific_membrane_antigen	0,34	PSMA	Prostate-specific membrane antigen	2346	2346	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Prostate-specific_membrane_antigen -LRB- PSMA -RRB- protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate_adenocarcinoma : an immunohistochemical study using mutiple tumour tissue microarray technique .
15555338	0	PSMA	50,54	hK2	45,48	PSMA	hK2	2346	58164	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	-LSB- Clinical significance of expression of PSA , hK2 , PSMA in the peripheral blood of patients with prostate_cancer -RSB- .
14716746	0	PSMA	60,64	prostate-specific_membrane_antigen	24,58	PSMA	prostate-specific membrane antigen	2346	2346	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Comparative analysis of prostate-specific_membrane_antigen -LRB- PSMA -RRB- versus a prostate-specific_membrane_antigen-like gene .
18802790	0	PSMA	53,57	prostate-specific_membrane_antigen	17,51	PSMA	prostate-specific membrane antigen	2346	2346	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Heterogeneity of prostate-specific_membrane_antigen -LRB- PSMA -RRB- expression in prostate_carcinoma with distant metastasis .
20568777	0	PSMA	63,67	prostate-specific_membrane_antigen	27,61	PSMA	prostate-specific membrane antigen	2346	2346	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|nmod|END_ENTITY	68Ga-labeled inhibitors of prostate-specific_membrane_antigen -LRB- PSMA -RRB- for imaging prostate_cancer .
22497258	0	PSMA	119,123	prostate-specific_membrane_antigen	83,117	PSMA	prostate-specific membrane antigen	2346	2346	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Structure-activity relationships of 2 ' ,5 ' - oligoadenylate analogue modifications of prostate-specific_membrane_antigen -LRB- PSMA -RRB- antagonists .
24425321	0	PSMA	69,73	prostate-specific_membrane_antigen	33,67	PSMA	prostate-specific membrane antigen	2346	2346	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Production of nanobodies against prostate-specific_membrane_antigen -LRB- PSMA -RRB- recognizing LnCaP cells .
26576996	0	PSMA	81,85	prostate-specific_membrane_antigen	45,79	PSMA	prostate-specific membrane antigen	2346	2346	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Alterations in androgen deprivation enhanced prostate-specific_membrane_antigen -LRB- PSMA -RRB- expression in prostate_cancer cells as a target for diagnostics and therapy .
9800328	0	PSMA4	35,40	proteasome_subunit_A4	12,33	PSMA4	proteasome subunit A4	397058(Tax:9823)	397058(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The porcine proteasome_subunit_A4 -LRB- PSMA4 -RRB- gene : isolation of a partial cDNA , linkage and physical mapping .
23839082	0	PSMA7	0,5	NOD1	30,34	PSMA7	NOD1	5688	10392	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PSMA7 directly interacts with NOD1 and regulates its function .
18565852	0	PSMB5	68,73	proteasome_subunit_beta5	42,66	PSMB5	proteasome subunit beta5	5693	5693	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular basis of bortezomib resistance : proteasome_subunit_beta5 -LRB- PSMB5 -RRB- gene mutation and overexpression of PSMB5 protein .
21098669	0	PSMB8	84,89	proteasome_subunit_beta-type_8	47,77	PSMB8	proteasome subunit beta-type 8	100049532(Tax:8090)	100049532(Tax:8090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transspecies dimorphic allelic lineages of the proteasome_subunit_beta-type_8 gene -LRB- PSMB8 -RRB- in the teleost genus Oryzias .
22322674	0	PSMB8	74,79	proteasome_subunit_beta_type-8	42,72	PSMB8	proteasome subunit beta type-8	399439(Tax:8355)	399439(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Highly divergent dimorphic alleles of the proteasome_subunit_beta_type-8 -LRB- PSMB8 -RRB- gene of the bichir Polypterus senegalus : implication for evolution of the PSMB8 gene of jawed vertebrates .
22491037	0	PSMB8	71,76	proteasome_subunit_beta_type_8	39,69	PSMB8	proteasome subunit beta type 8	550488(Tax:7955)	550488(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Long-lived dichotomous lineages of the proteasome_subunit_beta_type_8 -LRB- PSMB8 -RRB- gene surviving more than 500 million years as alleles or paralogs .
20069546	0	PSMD9	0,5	MODY3	19,24	PSMD9	MODY3	5715	6927	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	PSMD9 is linked to MODY3 .
24770418	0	PSMF1	38,43	PI31	32,36	PSMF1	PI31	9491	9491	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Molecular and cellular roles of PI31 -LRB- PSMF1 -RRB- protein in regulation of proteasome function .
26653889	0	PSORS1C1	66,74	psoriasis_susceptibility_1_candidate_1	26,64	PSORS1C1	psoriasis susceptibility 1 candidate 1	170679	170679	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphism within the psoriasis_susceptibility_1_candidate_1 -LRB- PSORS1C1 -RRB- gene is not linked to HLA-B * 58:01 in an Australian cohort .
15654961	0	PSORS2	66,72	RUNX1	44,49	PSORS2	RUNX1	79092	861	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts .
18855124	0	PSP	70,73	Personal_and_Social_Performance_scale	31,68	PSP	Personal and Social Performance scale	140683	140683	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Psychometric properties of the Personal_and_Social_Performance_scale -LRB- PSP -RRB- among individuals with schizophrenia living in the community .
8631368	0	PSP	47,50	pancreatic_spasmolytic_Polypeptide	11,45	PSP	pancreatic spasmolytic Polypeptide	24714(Tax:10116)	24714(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of pancreatic_spasmolytic_Polypeptide -LRB- PSP -RRB- on epithelial cell function .
1429019	0	PSP	72,75	pancreatic_spasmolytic_polypeptide	36,70	PSP	pancreatic spasmolytic polypeptide	397420(Tax:9823)	397420(Tax:9823)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of pancreatic_spasmolytic_polypeptide -LRB- PSP -RRB- in the pig .
2114355	0	PSTI	84,88	C-reactive_protein	21,39	PSTI	C-reactive protein	6690	1401	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	Serum interleukin_6 , C-reactive_protein and pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- as acute phase reactants after major thoraco-abdominal surgery .
2434267	0	PSTI	119,123	PSTI	31,35	PSTI	PSTI	6690	6690	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Serum levels of immunoreactive PSTI in acute abdominal_disorders , with special reference to a possible extrapancreatic PSTI production .
2434267	0	PSTI	31,35	PSTI	119,123	PSTI	PSTI	6690	6690	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Serum levels of immunoreactive PSTI in acute abdominal_disorders , with special reference to a possible extrapancreatic PSTI production .
8244568	0	PSTI	67,71	pancreatic-secretory-trypsin-inhibitor	27,65	PSTI	pancreatic-secretory-trypsin-inhibitor	6690	6690	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Specific expression of the pancreatic-secretory-trypsin-inhibitor -LRB- PSTI -RRB- gene in hepatocellular_carcinoma .
2257226	0	PSTI	54,58	pancreatic_secretory_trypsin_inhibitor	14,52	PSTI	pancreatic secretory trypsin inhibitor	6690	6690	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- in colorectal_cancer .
2403744	0	PSTI	69,73	pancreatic_secretory_trypsin_inhibitor	29,67	PSTI	pancreatic secretory trypsin inhibitor	6690	6690	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study on pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- in gastric_carcinomas .
2436966	0	PSTI	65,69	pancreatic_secretory_trypsin_inhibitor	25,63	PSTI	pancreatic secretory trypsin inhibitor	6690	6690	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of serum pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- in patients with malabsorption_syndrome .
2734496	0	PSTI	58,62	pancreatic_secretory_trypsin_inhibitor	18,56	PSTI	pancreatic secretory trypsin inhibitor	6690	6690	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	-LSB- Changes in serum pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- during and after heart surgery -RSB- .
6172356	0	PSTI	104,108	trypsin-pancreatic_secretory_trypsin_inhibitor	56,102	PSTI	trypsin-pancreatic secretory trypsin inhibitor	6690	6690	Gene	Gene	complexes|appos|START_ENTITY complexes|amod|END_ENTITY	Studies on the interaction of Trasylol -LRB- aprotinin -RRB- with trypsin-pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- complexes and with alpha_2-macroglobulin-trypsin-PSTI-complexes .
26304991	0	PSTPIP2	0,7	SHIP1	95,100	PSTPIP2	SHIP1	9050	3635	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	PSTPIP2 , a Protein Associated with Autoinflammatory_Disease , Interacts with Inhibitory Enzymes SHIP1 and Csk .
26304991	0	PSTPIP2	0,7	SHIP1	95,100	PSTPIP2	SHIP1	9050	3635	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	PSTPIP2 , a Protein Associated with Autoinflammatory_Disease , Interacts with Inhibitory Enzymes SHIP1 and Csk .
22241480	0	PSY	44,47	phytoene_synthase	25,42	PSY	phytoene synthase	106371962	106371962	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Retention of triplicated phytoene_synthase -LRB- PSY -RRB- genes in Brassica_napus_L .
20558332	0	PT-r	127,131	parathyroid_hormone	67,86	PT-r	parathyroid hormone	374308	5741	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Involvement of GCMB in the transcriptional regulation of the human parathyroid_hormone gene in a parathyroid-derived cell line PT-r : effects of calcium and 1,25 -LRB- OH -RRB- 2D3 .
21518792	0	PTB	20,23	RBM4	0,4	PTB	RBM4	5725	5936	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing .
20078941	0	PTB	38,41	ShcD	1,5	PTB	ShcD	5725	399694	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	-LSB- ShcD interacts with TrkC through its PTB and SH2 domains -RSB- .
20663410	0	PTB	33,36	ShcD	0,4	PTB	ShcD	5725	399694	Gene	Gene	TrkB|nmod|START_ENTITY interacts|nmod|TrkB interacts|nsubj|END_ENTITY	ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation .
8649976	0	PTB	34,37	polypyrimidine_tract_binding	4,32	PTB	polypyrimidine tract binding	5725	5725	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The polypyrimidine_tract_binding -LRB- PTB -RRB- protein interacts with single-stranded DNA in a sequence-specific manner .
11804786	0	PTB	69,72	polypyrimidine_tract_binding_protein	31,67	PTB	polypyrimidine tract binding protein	48571(Tax:7227)	48571(Tax:7227)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Lineage-specific expression of polypyrimidine_tract_binding_protein -LRB- PTB -RRB- in Drosophila embryos .
26309807	0	PTB-Associated_Splicing_Factor	4,34	Peroxisome_Proliferator-Activated_Receptor_Gamma	35,83	PTB-Associated Splicing Factor	Peroxisome Proliferator-Activated Receptor Gamma	6421	5468	Gene	Gene	START_ENTITY|parataxis|Regulates Regulates|nsubj|Axis Axis|compound|END_ENTITY	The PTB-Associated_Splicing_Factor / Peroxisome_Proliferator-Activated_Receptor_Gamma Axis Regulates Autophagosome Formation in Human Pancreatic_Cancer Cells .
26047657	0	PTBP1	0,5	ADAR1	14,19	PTBP1	ADAR1	5725	103	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas .
26047657	0	PTBP1	0,5	p110	20,24	PTBP1	p110	5725	9733	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas .
21186367	0	PTBP2	23,28	AID	67,70	PTBP2	AID	58155	57379	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA .
8395005	0	PTC1	105,109	PTP2	50,54	PTC1	PTP2	851558(Tax:4932)	854383(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Mutations in a protein tyrosine phosphatase gene -LRB- PTP2 -RRB- and a protein serine/threonine phosphatase gene -LRB- PTC1 -RRB- cause a synthetic growth defect in Saccharomyces_cerevisiae .
10200051	0	PTCH	85,89	patched	76,83	PTCH	patched	5727	5727	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gorlin syndrome : identification of 4 novel germ-line mutations of the human patched -LRB- PTCH -RRB- gene .
10554356	0	PTCH	24,28	patched	15,22	PTCH	patched	5727	5727	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Involvement of patched -LRB- PTCH -RRB- gene in Gorlin_syndrome and related disorders : three family cases .
9192803	0	PTCH	15,19	patched	6,13	PTCH	patched	5727	5727	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Human patched -LRB- PTCH -RRB- mRNA is overexpressed consistently in tumor cells of both familial_and_sporadic_basal_cell_carcinoma .
26189965	0	PTCH1	17,22	MeCP2	53,58	PTCH1	MeCP2	5727	4204	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular_carcinoma SMMC-7721 cells .
26189965	0	PTCH1	17,22	Melittin	0,8	PTCH1	Melittin	5727	406130(Tax:7460)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular_carcinoma SMMC-7721 cells .
24073265	0	PTCH1	39,44	Patched1	29,37	PTCH1	Patched1	5727	5727	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variations in Patched1 -LRB- PTCH1 -RRB- gene and risk of hirschsprung_disease in the Han Chinese population .
24241535	0	PTDSS1	65,71	phosphatidylserine_synthase_1	34,63	PTDSS1	phosphatidylserine synthase 1	9791	9791	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gain-of-function mutations in the phosphatidylserine_synthase_1 -LRB- PTDSS1 -RRB- gene cause Lenz-Majewski_syndrome .
12869565	0	PTEN	58,62	AKT	105,108	PTEN	AKT	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY alter|dobj|function alter|xcomp|regulate regulate|dobj|cascades cascades|compound|END_ENTITY	Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol_3-kinase / AKT cascades .
17341655	0	PTEN	0,4	AKT	20,23	PTEN	AKT	5728	207	Gene	Gene	START_ENTITY|appos|more more|nmod|pathway pathway|compound|END_ENTITY	PTEN , more than the AKT pathway .
17924977	0	PTEN	94,98	AKT	26,29	PTEN	AKT	5728	207	Gene	Gene	mutations|compound|START_ENTITY occurs|nmod|mutations occurs|nsubj|activation activation|nmod|END_ENTITY	Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial_cancer and may be associated with favorable prognosiss .
18231751	0	PTEN	121,125	AKT	70,73	PTEN	AKT	5728	207	Gene	Gene	gene|compound|START_ENTITY Reversal|nmod|gene Reversal|nmod|END_ENTITY	Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian_cancer cell line by wild-type PTEN gene .
18374229	0	PTEN	15,19	AKT	109,112	PTEN	AKT	5728	207	Gene	Gene	Combination|nmod|START_ENTITY enhances|nsubj|Combination M|dep|enhances M|dep|arrest arrest|nmod|regulation regulation|nmod|activity activity|compound|END_ENTITY	Combination of PTEN and gamma-ionizing radiation enhances cell death and G -LRB- 2 -RRB- / M arrest through regulation of AKT activity and p21 induction in non-small-cell_lung_cancer cells .
18831514	0	PTEN	15,19	AKT	99,102	PTEN	AKT	5728	207	Gene	Gene	methylation|compound|START_ENTITY Association|nmod|methylation Association|parataxis|signaling signaling|nsubj|END_ENTITY	Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol_3-kinase / AKT signaling pathway in thyroid_tumors .
18937284	0	PTEN	38,42	AKT	58,61	PTEN	AKT	5728	207	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast_cancer cells .
19225041	0	PTEN	92,96	AKT	13,16	PTEN	AKT	5728	207	Gene	Gene	increase|nmod|START_ENTITY suppressed|nmod|increase suppressed|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	IGF1-induced AKT phosphorylation and cell proliferation are suppressed with the increase in PTEN during luteinization in human granulosa cells .
20154081	0	PTEN	71,75	AKT	42,45	PTEN	AKT	5728	207	Gene	Gene	suppression|compound|START_ENTITY keratinocytes|nmod|suppression END_ENTITY|nmod|keratinocytes	Immunosuppressive cyclosporin_A activates AKT in keratinocytes through PTEN suppression : implications in skin_carcinogenesis .
20596030	0	PTEN	165,169	AKT	104,107	PTEN	AKT	5728	207	Gene	Gene	gene|compound|START_ENTITY silencing|nmod|gene signaling|nmod|silencing activations|acl|signaling activations|nmod|END_ENTITY	Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT , ERK and STAT5 signaling via epigenetic silencing of the PTEN gene .
21129241	0	PTEN	30,34	AKT	40,43	PTEN	AKT	5728	207	Gene	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	-LSB- Correlation of expression of PTEN with AKT phosphorylation level in leukemia cells -RSB- .
21953448	0	PTEN	159,163	AKT	254,257	PTEN	AKT	5728	207	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Hydrogen_sulfide and L-cysteine increase phosphatidylinositol_3 ,4,5 - trisphosphate -LRB- PIP3 -RRB- and glucose utilization by inhibiting phosphatase and tensin homolog -LRB- PTEN -RRB- protein and activating phosphoinositide_3-kinase -LRB- PI3K -RRB- / serine/threonine protein kinase -LRB- AKT -RRB- / protein kinase C / -LRB- PKC / -RRB- in 3T3l1 adipocytes .
22885155	0	PTEN	88,92	AKT	63,66	PTEN	AKT	5728	207	Gene	Gene	targeting|dobj|START_ENTITY enhances|advcl|targeting enhances|dobj|potential potential|nmod|cells cells|nmod|END_ENTITY	MiR-26a enhances metastasis potential of lung_cancer cells via AKT pathway by targeting PTEN .
23132328	0	PTEN	108,112	AKT	166,169	PTEN	AKT	5728	207	Gene	Gene	modulation|nmod|START_ENTITY traumatic_brain_injury|nmod|modulation protects|nmod|traumatic_brain_injury protects|parataxis|protects protects|nmod|TBI TBI|nmod|END_ENTITY	Scriptaid , a novel histone deacetylase inhibitor , protects against traumatic_brain_injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT .
23788636	0	PTEN	159,163	AKT	26,29	PTEN	AKT	5728	207	Gene	Gene	homolog|appos|START_ENTITY dephosphorylation|nmod|homolog loop|acl|dephosphorylation loop|compound|END_ENTITY	Notch1 receptor regulates AKT protein activation loop -LRB- Thr308 -RRB- dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog -LRB- PTEN -RRB- - null T-cell_acute_lymphoblastic_leukemia cells .
23856247	0	PTEN	16,20	AKT	43,46	PTEN	AKT	5728	207	Gene	Gene	targets|dobj|START_ENTITY targets|xcomp|augment augment|dobj|signaling signaling|compound|END_ENTITY	miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small_cell_lung_cancer .
24270425	0	PTEN	24,28	AKT	0,3	PTEN	AKT	5728	207	Gene	Gene	promotes|xcomp|START_ENTITY promotes|nsubj|activation activation|compound|END_ENTITY	AKT activation promotes PTEN hamartoma_tumor_syndrome-associated cataract development .
25026288	0	PTEN	8,12	AKT	85,88	PTEN	AKT	5728	207	Gene	Gene	Loss|nmod|START_ENTITY stabilizes|nsubj|Loss stabilizes|dobj|lipid lipid|acl|modifying modifying|dobj|a a|nmod|END_ENTITY	Loss of PTEN stabilizes the lipid modifying enzyme cytosolic phospholipase A a via AKT in prostate_cancer cells .
25344626	0	PTEN	116,120	AKT	122,125	PTEN	AKT	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	Notch|appos|START_ENTITY Regulation|nmod|Notch Regulation|parataxis|pathways pathways|nsubj|END_ENTITY	Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase_and_tensin_homologue -LRB- PTEN -RRB- / AKT pathways .
25770423	0	PTEN	11,15	AKT	66,69	PTEN	AKT	5728	207	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|activation activation|compound|END_ENTITY	Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization .
25925379	0	PTEN	69,73	AKT	17,20	PTEN	AKT	5728	207	Gene	Gene	Methylation|nmod|START_ENTITY Dysregulation|nmod|Methylation Dysregulation|nmod|Pathway Pathway|compound|END_ENTITY	Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN .
26986476	0	PTEN	0,4	ATM	88,91	PTEN	ATM	5728	472	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	PTEN enhances G2/M arrest in etoposide-treated MCF -7 cells through activation of the ATM pathway .
11071655	0	PTEN	8,12	Akt	40,43	PTEN	Akt	5728	207	Gene	Gene	expression|compound|START_ENTITY Loss|nmod|expression Loss|acl|leading leading|nmod|activation activation|compound|END_ENTITY	Loss of PTEN expression leading to high Akt activation in human multiple_myelomas .
11162641	0	PTEN	89,93	Akt	82,85	PTEN	Akt	5728	207	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells .
11368352	0	PTEN	157,161	Akt	13,16	PTEN	Akt	50557(Tax:10116)	24185(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY evidence|nmod|inhibition occurs|dobj|evidence occurs|nsubj|Induction Induction|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol_3-kinase : no evidence for oxidative inhibition of PTEN .
11395387	0	PTEN	17,21	Akt	70,73	PTEN	Akt	5728	207	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression linked|nsubj|loss linked|nmod|levels levels|compound|END_ENTITY	Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels , but not associated with p27 and cyclin_D1 expression , in primary_epithelial_ovarian_carcinomas .
12622404	0	PTEN	0,4	Akt	15,18	PTEN	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis .
12790783	0	PTEN	8,12	Akt	36,39	PTEN	Akt	5728	207	Gene	Gene	expression|compound|START_ENTITY expression|acl|followed followed|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial_cancer .
12923562	0	PTEN	50,54	Akt	109,112	PTEN	Akt	5728	207	Gene	Gene	growth|compound|START_ENTITY bladder_cancer|nmod|growth therapy|nmod|bladder_cancer phosphorylated|nmod|therapy phosphorylated|dobj|END_ENTITY	In vivo gene therapy of human bladder_cancer with PTEN suppresses tumor growth , downregulates phosphorylated Akt , and increases sensitivity to doxorubicin .
14566704	0	PTEN	25,29	Akt	80,83	PTEN	Akt	5728	207	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|parataxis|cause cause|nsubj|END_ENTITY	Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase / Akt pathway cause human Lhermitte-Duclos_disease in adults .
14603261	0	PTEN	10,14	Akt	32,35	PTEN	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY Levels|nmod|protein modulate|nsubj|Levels modulate|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Levels of PTEN protein modulate Akt phosphorylation on serine 473 , but not on threonine 308 , in IGF-II-overexpressing rhabdomyosarcomas cells .
15482376	0	PTEN	118,122	Akt	77,80	PTEN	Akt	50557(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY prevents|nmod|phosphorylation prevents|dobj|damages damages|nmod|activation activation|nmod|END_ENTITY	17_Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats .
15851405	0	PTEN	68,72	Akt	0,3	PTEN	Akt	5728	207	Gene	Gene	expression|compound|START_ENTITY contribution|nmod|expression activation|dep|contribution activation|compound|END_ENTITY	Akt activation in renal_cell_carcinoma : contribution of a decreased PTEN expression and the induction of apoptosis by an Akt inhibitor .
15900596	0	PTEN	43,47	Akt	0,3	PTEN	Akt	5728	207	Gene	Gene	LOH|nmod|START_ENTITY END_ENTITY|nmod|LOH	Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric_cancer .
16169459	0	PTEN	40,44	Akt	54,57	PTEN	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	gets|nsubj|START_ENTITY gets|dobj|END_ENTITY	A new mouse model of pancreatic_cancer : PTEN gets its Akt together .
16324768	0	PTEN	46,50	Akt	15,18	PTEN	Akt	5728	207	Gene	Gene	expression|compound|START_ENTITY overexpression|nmod|expression overexpression|compound|END_ENTITY	Phosphorylated Akt overexpression and loss of PTEN expression in non-small_cell_lung_cancer confers poor prognosis .
17006756	0	PTEN	49,53	Akt	97,100	PTEN	Akt	5728	207	Gene	Gene	locus|compound|START_ENTITY heterozygosity|nmod|locus loss|nmod|heterozygosity Coexistence|nmod|loss enhances|nsubj|Coexistence enhances|dobj|activity activity|compound|END_ENTITY	Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone_receptor expression in breast_carcinoma .
17013611	0	PTEN	33,37	Akt	14,17	PTEN	Akt	5728	207	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|Activation Activation|nmod|END_ENTITY	Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical_dysplasias .
17276010	0	PTEN	14,18	Akt	37,40	PTEN	Akt	5728	207	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of PTEN and activation of Akt by menadione .
17302912	0	PTEN	14,18	Akt	76,79	PTEN	Akt	50557(Tax:10116)	24185(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY activates|nsubj|Inhibition activates|dobj|neuroprotective neuroprotective|compound|END_ENTITY	Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase / Akt neuroprotective signaling pathway .
17369849	0	PTEN	87,91	Akt	0,3	PTEN	Akt	5728	207	Gene	Gene	suppressor|compound|START_ENTITY oxidation|nmod|suppressor occurs|nmod|oxidation occurs|nsubj|activation activation|compound|END_ENTITY	Akt activation by arachidonic_acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor .
17681738	0	PTEN	35,39	Akt	62,65	PTEN	Akt	5728	207	Gene	Gene	protein|compound|START_ENTITY Co-existence|nmod|protein Co-existence|nmod|activation activation|compound|END_ENTITY	Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal_cell_carcinoma .
18425369	0	PTEN	0,4	Akt	98,101	PTEN	Akt	5728	207	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|majority majority|dep|implications implications|nmod|activation activation|compound|END_ENTITY	PTEN and p27Kip1 are not downregulated in the majority of renal_cell_carcinomas -- implications for Akt activation .
19160672	0	PTEN	15,19	Akt	63,66	PTEN	Akt	5728	207	Gene	Gene	activity|compound|START_ENTITY Measurement|nmod|activity phosphorylated|nsubj|Measurement phosphorylated|dobj|END_ENTITY	Measurement of PTEN activity in vivo by imaging phosphorylated Akt .
19318457	0	PTEN	175,179	Akt	60,63	PTEN	Akt	5728	207	Gene	Gene	increase|nmod|START_ENTITY kinase|nmod|increase attenuates|parataxis|kinase attenuates|dobj|factor-I factor-I|dep|pathway pathway|compound|END_ENTITY	Insulin attenuates the insulin-like growth factor-I -LRB- IGF-I -RRB- - Akt pathway , not IGF-I-extracellularly regulated kinase pathway , in luteinized granulosa cells with an increase in PTEN .
19543271	0	PTEN	88,92	Akt	19,22	PTEN	Akt	5728	207	Gene	Gene	targeting|dobj|START_ENTITY targeting|nsubj|END_ENTITY	TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN .
20854947	0	PTEN	110,114	Akt	67,70	PTEN	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY suppression|nmod|activity transduction|nmod|suppression transduction|compound|END_ENTITY	Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity .
20975834	0	PTEN	35,39	Akt	50,53	PTEN	Akt	5728	207	Gene	Gene	Alkylation|nmod|START_ENTITY activates|nsubj|Alkylation activates|xcomp|END_ENTITY	Alkylation of the tumor suppressor PTEN activates Akt and b-catenin signaling : a mechanism linking inflammation and oxidative stress with cancer .
21415306	0	PTEN	57,61	Akt	113,116	PTEN	Akt	5728	207	Gene	Gene	homolog|appos|START_ENTITY inhibition|nsubj|homolog inhibition|nmod|activation activation|compound|END_ENTITY	Phosphatase and tensin homolog deleted on chromosome 10 -LRB- PTEN -RRB- inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes .
22000581	0	PTEN	118,122	Akt	56,59	PTEN	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY down-regulation|dep|roles down-regulation|nmod|expression expression|compound|END_ENTITY	Zinc_deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis : essential roles of PTEN , PTP1B and TRB3 .
22488521	0	PTEN	15,19	Akt	65,68	PTEN	Akt	5728	207	Gene	Gene	Attenuation|nmod|START_ENTITY perturbs|nsubj|Attenuation perturbs|dobj|stability stability|nmod|activation activation|nmod|END_ENTITY	Attenuation of PTEN perturbs genomic stability via activation of Akt and down-regulation of Rad51 in human embryonic kidney cells .
22940494	0	PTEN	50,54	Akt	27,30	PTEN	Akt	5728	207	Gene	Gene	cells|compound|START_ENTITY phosphorylation|nmod|cells phosphorylation|compound|END_ENTITY	Redox control of cytosolic Akt phosphorylation in PTEN null cells .
24295494	0	PTEN	96,100	Akt	77,80	PTEN	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	status|compound|START_ENTITY independent|nmod|status independent|nsubj|END_ENTITY	miR-221 / 222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status .
25683168	0	PTEN	11,15	Akt	111,114	PTEN	Akt	5728	207	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Effects of PTEN on the proliferation and apoptosis of colorectal_cancer cells via the phosphoinositol-3-kinase / Akt pathway .
25934712	0	PTEN	12,16	Akt	102,105	PTEN	Akt	5728	207	Gene	Gene	Contributes|compound|START_ENTITY Contributes|nmod|Resistance Resistance|nmod|Cancer Cancer|nmod|Activation Activation|nmod|END_ENTITY	Correction : PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR .
26000878	0	PTEN	116,120	Akt	141,144	PTEN	Akt	5728	207	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation .
26148798	0	PTEN	72,76	Akt	111,114	PTEN	Akt	5728	207	Gene	Gene	phosphatase|appos|START_ENTITY END_ENTITY|nsubj|phosphatase	Small RNA profiling reveals deregulated phosphatase and tensin homolog -LRB- PTEN -RRB- / phosphoinositide 3-kinase -LRB- PI3K -RRB- / Akt pathway in bronchial smooth muscle cells from asthmatic patients .
26173079	0	PTEN	128,132	Akt	153,156	PTEN	Akt	5728	207	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Correction : Fractionated Ionizing Radiation Promotes Epithelial-Mesenchymal Transition in Human Esophageal Cancer Cells through PTEN Deficiency-Mediated Akt Activation .
26666444	0	PTEN	24,28	Akt	136,139	PTEN	Akt	50557(Tax:10116)	24185(Tax:10116)	Gene	Gene	Cardioprotection|compound|START_ENTITY Inhibition|nmod|Cardioprotection Inhibition|parataxis|END_ENTITY	Selective Inhibition of PTEN Preserves Ischemic Postconditioning Cardioprotection in STZ-induced Type1 Diabetic Rats : Role of the PI3K / Akt and JAK2 / STAT3 Pathways .
9931326	0	PTEN	0,4	Akt/PKB	59,66	PTEN	Akt/PKB	5728	207	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological_malignancies .
16842674	0	PTEN	58,62	Angiotensin_II	1,15	PTEN	Angiotensin II	50557(Tax:10116)	24179(Tax:10116)	Gene	Gene	blocked|nmod|START_ENTITY blocked|nsubjpass|induced induced|compound|END_ENTITY	-LSB- Angiotensin_II induced cardiac_hypertrophy is blocked by PTEN via suppressing Ca2 + / Calcineurin pathway -RSB- .
25428915	0	PTEN	96,100	Aurora-A	0,8	PTEN	Aurora-A	5728	6790	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA -21 / PTEN signaling pathway .
25338572	0	PTEN	70,74	BAX	65,68	PTEN	BAX	5728	581	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2 / BAX , PTEN -RSB- .
25608112	0	PTEN	30,34	BCR-ABL	0,7	PTEN	BCR-ABL	5728	25	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation .
18059158	0	PTEN	15,19	BMP	0,3	PTEN	BMP	5728	649	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	BMP suppresses PTEN expression via RAS/ERK signaling .
21340604	0	PTEN	24,28	BRAF	18,22	PTEN	BRAF	5728	673	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
21725359	0	PTEN	23,27	BRAF	110,114	PTEN	BRAF	5728	673	Gene	Gene	loss|nmod|START_ENTITY attenuates|nsubj|loss attenuates|dobj|dependence dependence|nmod|END_ENTITY	Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring -LRB- V600E -RRB- BRAF .
24594201	0	PTEN	38,42	BRAF	32,36	PTEN	BRAF	5728	673	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
26341080	0	PTEN	32,36	BRAF	20,24	PTEN	BRAF	5728	673	Gene	Gene	Number|appos|START_ENTITY Number|compound|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
21102582	0	PTEN	14,18	BRG1	75,79	PTEN	BRG1	5728	6597	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of PTEN expression by the SWI/SNF chromatin-remodelling protein BRG1 in human colorectal_carcinoma cells .
19884659	0	PTEN	64,68	Bmi-1	27,32	PTEN	Bmi-1	5728	648	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells .
24140063	0	PTEN	47,51	C-Myc	0,5	PTEN	C-Myc	5728	4609	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells .
25756512	0	PTEN	0,4	CCL2	60,64	PTEN	CCL2	19211(Tax:10090)	20296(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism .
23729286	0	PTEN	39,43	CD95	50,54	PTEN	CD95	5728	355	Gene	Gene	FAS|appos|START_ENTITY FAS|appos|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
25770423	0	PTEN	11,15	COX-2	19,24	PTEN	COX-2	5728	4513	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization .
15766664	0	PTEN	48,52	DJ-1	0,4	PTEN	DJ-1	5728	11315	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	DJ-1 , a novel regulator of the tumor suppressor PTEN .
17949781	0	PTEN	62,66	DJ-1	32,36	PTEN	DJ-1	5728	11315	Gene	Gene	regulator|nmod|START_ENTITY role|appos|regulator role|nmod|END_ENTITY	Expression and clinical role of DJ-1 , a negative regulator of PTEN , in ovarian_carcinoma .
19885556	0	PTEN	82,86	DJ-1	74,78	PTEN	DJ-1	5728	11315	Gene	Gene	transformation|nmod|START_ENTITY transformation|nmod|binding binding|nmod|END_ENTITY	Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN .
21823007	0	PTEN	71,75	DJ-1	12,16	PTEN	DJ-1	50557(Tax:10116)	117287(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression promotes|advcl|suppressing promotes|nsubj|END_ENTITY	Upregulated DJ-1 promotes renal tubular EMT by suppressing cytoplasmic PTEN expression and Akt activation .
23151319	0	PTEN	78,82	DJ-1	48,52	PTEN	DJ-1	5728	11315	Gene	Gene	regulator|nmod|START_ENTITY role|appos|regulator role|nmod|END_ENTITY	Tumorigenesis role and clinical significance of DJ-1 , a negative regulator of PTEN , in supraglottic_squamous_cell_carcinoma .
26399523	0	PTEN	0,4	Dishevelled	29,40	PTEN	Dishevelled	5728	8215	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	PTEN regulates cilia through Dishevelled .
18386291	0	PTEN	15,19	EGFR	82,86	PTEN	EGFR	5728	1956	Gene	Gene	expression|compound|START_ENTITY Restoration|nmod|expression alters|nsubj|Restoration alters|nmod|inhibitors inhibitors|amod|END_ENTITY	Restoration of PTEN expression alters the sensitivity of prostate_cancer cells to EGFR inhibitors .
18704985	0	PTEN	52,56	EGFR	21,25	PTEN	EGFR	5728	1956	Gene	Gene	losses|nmod|START_ENTITY losses|compound|END_ENTITY	Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma_tumors .
19657395	0	PTEN	74,78	EGFR	31,35	PTEN	EGFR	5728	1956	Gene	Gene	identified|dobj|START_ENTITY identified|nsubj|analysis analysis|nmod|END_ENTITY	Gene expression analysis of an EGFR indirectly related pathway identified PTEN and MMP9 as reliable diagnostic markers for human glial_tumor specimens .
19763916	0	PTEN	14,18	EGFR	82,86	PTEN	EGFR	5728	1956	Gene	Gene	expressions|compound|START_ENTITY Evaluation|nmod|expressions Evaluation|acl|expressing expressing|dobj|END_ENTITY	Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR .
20018398	0	PTEN	0,4	EGFR	35,39	PTEN	EGFR	5728	1956	Gene	Gene	START_ENTITY|nmod|KRAS KRAS|compound|END_ENTITY	PTEN mutations and relationship to EGFR , ERBB2 , KRAS , and TP53 mutations in non-small_cell_lung_cancers .
21952748	0	PTEN	36,40	EGFR	0,4	PTEN	EGFR	5728	1956	Gene	Gene	expression|compound|START_ENTITY reduction|nmod|expression reduction|amod|END_ENTITY	EGFR - and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial_cancer cells .
22240798	0	PTEN	8,12	EGFR	41,45	PTEN	EGFR	5728	1956	Gene	Gene	Loss|nmod|START_ENTITY associated|nsubjpass|Loss associated|nmod|END_ENTITY	Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary_gland_cancer .
22414288	4	PTEN	593,597	EGFR	503,507	PI3K	PTEN	5293	5728	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|nmod|PTEN PTEN|compound|END_ENTITY	METHODS AND MATERIALS : MCF-7 cell lines with low expression of EGFR and wild-type PTEN and MDA-MB-468 cell lines with high expression of EGFR and mutant PTEN were used .
23261230	0	PTEN	43,47	EGFR	93,97	PTEN	EGFR	5728	1956	Gene	Gene	syndrome|amod|START_ENTITY syndrome|dep|END_ENTITY	Primary lung_adenocarcinoma occurring in a PTEN related syndrome -LRB- Cowden 's _ disease -RRB- : routine EGFR sequencing also highlights two rare somatic mutations S768I and V769L .
24594201	0	PTEN	38,42	EGFR	20,24	PTEN	EGFR	5728	1956	Gene	Gene	mutations|dep|START_ENTITY mutations|compound|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
25870120	0	PTEN	82,86	EGFR	120,124	PTEN	EGFR	5728	1956	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Basal_cell_carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR .
26341080	0	PTEN	32,36	EGFR	38,42	PTEN	EGFR	5728	1956	Gene	Gene	Number|appos|START_ENTITY Number|appos|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
26869029	0	PTEN	0,4	EGFR	15,19	PTEN	EGFR	5728	1956	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|trafficking trafficking|amod|END_ENTITY	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7 .
21076047	0	PTEN	8,12	ERK1/2	58,64	PTEN	ERK1/2	5728	5595;5594	Gene	Gene	Loss|nmod|START_ENTITY permits|nsubj|Loss permits|nmod|END_ENTITY	Loss of PTEN permits CXCR4-mediated tumorigenesis through ERK1/2 in prostate_cancer cells .
22737980	0	PTEN	0,4	ERK1/2	19,25	PTEN	ERK1/2	5728	5595;5594	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	PTEN regulation of ERK1/2 signaling in cancer .
21719208	0	PTEN	49,53	EZH2	18,22	PTEN	EZH2	5728	2146	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Overexpression of EZH2 and loss of expression of PTEN is associated with invasion , metastasis , and poor progression of gallbladder_adenocarcinoma .
21289308	0	PTEN	15,19	Evi1	0,4	PTEN	Evi1	5728	2122	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins .
23135913	0	PTEN	17,21	Ezh2	117,121	PTEN	Ezh2	5728	2146	Gene	Gene	suppressor|compound|START_ENTITY acts|nmod|suppressor acts|xcomp|elicit elicit|nmod|activation activation|nmod|methyltransferase methyltransferase|amod|END_ENTITY	MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase .
19911253	0	PTEN	47,51	FABP4	96,101	PTEN	FABP4	5728	2167	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Identification of novel PTEN-binding partners : PTEN interaction with fatty_acid binding protein FABP4 .
18787170	0	PTEN	55,59	FBXW7	0,5	PTEN	FBXW7	5728	55294	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression .
22021428	0	PTEN	27,31	GATA2	0,5	PTEN	GATA2	5728	2624	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen_receptor and by androgen-independent suppression of PTEN transcription in breast_cancer .
22999923	0	PTEN	87,91	GSK-3b	80,86	PTEN	GSK-3b	5728	2932	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3b / PTEN pathway .
17043650	0	PTEN	75,79	GSK3_beta	0,9	PTEN	GSK3 beta	19211(Tax:10090)	56637(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	GSK3_beta mediates suppression of cyclin_D2 expression by tumor suppressor PTEN .
20079187	0	PTEN	37,41	Glut-1	29,35	PTEN	Glut-1	5728	6513	Gene	Gene	proteins|dep|START_ENTITY proteins|dep|END_ENTITY	-LSB- Expression of beta-catenin , Glut-1 , PTEN proteins in uterine endometrioid_adenocarcinoma and its precursor lesions -RSB- .
24788349	0	PTEN	18,22	HDAC2	53,58	PTEN	HDAC2	5728	3066	Gene	Gene	expression|compound|START_ENTITY restores|dobj|expression restores|nmod|END_ENTITY	Melittin restores PTEN expression by down-regulating HDAC2 in human hepatocelluar_carcinoma HepG2 cells .
12804776	0	PTEN	110,114	IGF-II	129,135	PTEN	IGF-II	5728	3481	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	PTEN_modulates_insulin-like_growth_factor_II _ -LRB- IGF-II -RRB- - mediated signaling ; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells .
17369847	0	PTEN	43,47	IGF-II	0,6	PTEN	IGF-II	5728	3481	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	IGF-II and IGFBP-2 differentially regulate PTEN in human breast_cancer cells .
15499378	0	PTEN	80,84	IGF1R	17,22	PTEN	IGF1R	5728	3480	Gene	Gene	wild-type|compound|START_ENTITY agents|nmod|wild-type enhances|nmod|agents enhances|nsubj|Silencing Silencing|nmod|gene gene|compound|END_ENTITY	Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate_cancer .
21340604	0	PTEN	24,28	IGF1R	30,35	PTEN	IGF1R	5728	3480	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
17982072	0	PTEN	0,4	IL-17	20,25	PTEN	IL-17	19211(Tax:10090)	16171(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	PTEN down-regulates IL-17 expression in a murine model of toluene_diisocyanate-induced airway_disease .
11668501	0	PTEN	39,43	KRAS	45,49	PTEN	KRAS	5728	3845	Gene	Gene	NRAS|dep|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
19212633	0	PTEN	0,4	KRAS	119,123	PTEN	KRAS	5728	3845	Gene	Gene	expression|compound|START_ENTITY controls|nsubj|expression controls|dobj|response response|acl|cetuximab cetuximab|advcl|mediating mediating|dobj|downstream downstream|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-type , hormone refractory_prostate_cancer cells .
19884556	0	PTEN	12,16	KRAS	99,103	PTEN	KRAS	5728	3845	Gene	Gene	Analysis|nmod|START_ENTITY status|nsubj|Analysis status|advcl|determining determining|nmod|therapy therapy|nmod|colon_cancer colon_cancer|compound|END_ENTITY	Analysis of PTEN , BRAF , and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon_cancer .
21340604	0	PTEN	24,28	KRAS	12,16	PTEN	KRAS	5728	3845	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Analysis of KRAS , BRAF , PTEN , IGF1R , EGFR intron 1 CA status in both primary_tumors and paired metastases in determining benefit from cetuximab therapy in colon_cancer .
22285706	0	PTEN	0,4	KRAS	163,167	PTEN	KRAS	5728	3845	Gene	Gene	START_ENTITY|nmod|therapy therapy|nmod|patients patients|nmod|colorectal_cancer colorectal_cancer|compound|END_ENTITY	PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal_growth_factor_receptor antibody therapy in patients with KRAS wild-type metastatic colorectal_cancer .
23996432	0	PTEN	12,16	KRAS	174,178	PTEN	KRAS	5728	3845	Gene	Gene	status|nmod|START_ENTITY refractory|nsubj|status refractory|xcomp|chemotherapy chemotherapy|nmod|END_ENTITY	Analysis of PTEN , BRAF and PI3K status for determination of benefit from cetuximab therapy in metastatic colorectal_cancer patients refractory to chemotherapy with wild-type KRAS .
24594201	0	PTEN	38,42	KRAS	26,30	PTEN	KRAS	5728	3845	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Spectrum of somatic EGFR , KRAS , BRAF , PTEN mutations and TTF-1 expression in Brazilian lung_cancer patients .
26341080	0	PTEN	32,36	KRAS	108,112	PTEN	KRAS	5728	3845	Gene	Gene	Number|appos|START_ENTITY Value|nmod|Number Value|nmod|Patients Patients|nmod|Chemotherapy Chemotherapy|compound|END_ENTITY	Prognostic Value of BRAF , PI3K , PTEN , EGFR Copy Number , Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy .
25850957	0	PTEN	74,78	LKB1	14,18	PTEN	LKB1	5728	6794	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	The Effect of LKB1 on the PI3K/Akt Pathway Activation in Association with PTEN and PIK3CA in HNC .
24038283	0	PTEN	31,35	MADD	0,4	PTEN	MADD	5728	8567	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MADD is a downstream target of PTEN in triggering apoptosis .
26910647	0	PTEN	74,78	MAF1	0,4	PTEN	MAF1	5728	84232	Gene	Gene	Transcription|compound|START_ENTITY Signaling|nmod|Transcription Signaling|compound|END_ENTITY	MAF1 Suppresses AKT-mTOR Signaling and Liver_Cancer through Activation of PTEN Transcription .
23453810	0	PTEN	21,25	MEK1	0,4	PI3K	MEK1	5293	5604	Gene	Gene	recruitment|compound|START_ENTITY required|nmod|recruitment required|nsubjpass|END_ENTITY	MEK1 is required for PTEN membrane recruitment , AKT regulation , and the maintenance of peripheral tolerance .
11908870	0	PTEN	60,64	MMAC1	53,58	PTEN	MMAC1	5728	5728	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Primary malignant_lymphoma of the brain : analysis of MMAC1 -LRB- PTEN -RRB- tumor suppressor gene .
9690672	0	PTEN	0,4	MMAC1	6,11	PTEN	MMAC1	5728	5728	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	PTEN -LRB- MMAC1 -RRB- mutations are frequent in primary_glioblastomas -LRB- de novo -RRB- but not in secondary_glioblastomas .
24143235	0	PTEN	102,106	MMP7	92,96	PTEN	MMP7	5728	4316	Gene	Gene	manner|compound|START_ENTITY END_ENTITY|nmod|manner	Differential activation of Wnt-b-catenin pathway in triple negative breast_cancer increases MMP7 in a PTEN dependent manner .
20620173	0	PTEN	92,96	MT1-MMP	189,196	PTEN	MT1-MMP	19211(Tax:10090)	17387(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY MT1-MMP|nmod|cells regulation|nmod|MT1-MMP regulation|dep|expression expression|nmod|END_ENTITY	Posttranslational regulation of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in mouse PTEN null prostate_cancer cells : Enhanced surface expression and differential O-glycosylation of MT1-MMP .
20620173	0	PTEN	92,96	MT1-MMP	74,81	PTEN	MT1-MMP	19211(Tax:10090)	17387(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Posttranslational regulation of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in mouse PTEN null prostate_cancer cells : Enhanced surface expression and differential O-glycosylation of MT1-MMP .
25692619	0	PTEN	115,119	MTOR	58,62	PTEN	MTOR	5728	2475	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression medullary_carcinoma|nmod|loss inhibitor|nmod|medullary_carcinoma inhibitor|amod|END_ENTITY	Therapeutic approach guided by genetic alteration : use of MTOR inhibitor in renal medullary_carcinoma with loss of PTEN expression .
25502566	0	PTEN	26,30	Maf1	0,4	PTEN	Maf1	19211(Tax:10090)	68877(Tax:10090)	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism .
25785728	0	PTEN	38,42	Maf1	12,16	PTEN	Maf1	5728	84232	Gene	Gene	Signaling|compound|START_ENTITY Target|nmod|Signaling Oncogenesis|nsubj|Target Is|xcomp|Oncogenesis Is|nsubj|END_ENTITY	Correction : Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism .
11729185	0	PTEN	0,4	Mdm2	23,27	PTEN	Mdm2	5728	4193	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy .
15090541	0	PTEN	0,4	Mdm2	15,19	PTEN	Mdm2	5728	4193	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	PTEN regulates Mdm2 expression through the P1 promoter .
26111969	0	PTEN	18,22	MiR-19a	0,7	PTEN	MiR-19a	19211(Tax:10090)	723891(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes .
24293118	0	PTEN	69,73	MiR-21	0,6	PTEN	MiR-21	5728	406991	Gene	Gene	gene|compound|START_ENTITY targeting|dobj|gene suppresses|advcl|targeting suppresses|nsubj|END_ENTITY	MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small_cell_lung_cancer A549 cells .
26651881	0	PTEN	109,113	MiR-21	0,6	PTEN	MiR-21	5728	406991	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression modulates|nmod|regulation modulates|nsubj|END_ENTITY	MiR-21 modulates human airway smooth muscle cell proliferation and migration in asthma through regulation of PTEN expression .
24286315	0	PTEN	100,104	MiR-221	0,7	PTEN	MiR-221	5728	407006	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-221 promotes trastuzumab-resistance and metastasis in HER2-positive_breast_cancers by targeting PTEN .
25790935	0	PTEN	99,103	MiR-301a	0,8	PTEN	MiR-301a	5728	407027	Gene	Gene	Expression|compound|START_ENTITY Mediates|nmod|Expression Mediates|nsubj|END_ENTITY	MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression .
24842611	0	PTEN	117,121	MicroRNA-106b	0,13	PTEN	MicroRNA-106b	5728	406900	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-106b in cancer-associated fibroblasts from gastric_cancer promotes cell migration and invasion by targeting PTEN .
27035216	0	PTEN	105,109	MicroRNA-130a	0,13	PTEN	MicroRNA-130a	5728	406919	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN .
20223231	0	PTEN	48,52	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- represses tumor suppressor PTEN and promotes growth and invasion in non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
21042775	0	PTEN	148,152	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein inhibiting|dobj|expression promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	MicroRNA-21 promotes the cell proliferation , invasion and migration abilities_in_ovarian_epithelial_carcinomas through inhibiting the expression of PTEN protein .
21820606	0	PTEN	90,94	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY doxorubicin|advcl|targeting modulates|xcomp|doxorubicin modulates|nsubj|END_ENTITY	MicroRNA-21 modulates chemosensitivity of breast_cancer cells to doxorubicin by targeting PTEN .
22956424	0	PTEN	140,144	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|expression expression|amod|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- expression promotes growth , metastasis , and chemo - or radioresistance in non-small_cell_lung_cancer cells by targeting PTEN .
23684551	0	PTEN	23,27	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular_carcinoma progression through AKT/ERK pathways .
24342610	0	PTEN	94,98	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY signaling|advcl|targeting PI3K/Akt|acl|signaling vitro|nmod|PI3K/Akt accelerates|nmod|vitro accelerates|nsubj|END_ENTITY	MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K/Akt signaling by targeting PTEN .
24817011	0	PTEN	32,36	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	hTERT|nmod|START_ENTITY regulates|dobj|hTERT regulates|nsubj|END_ENTITY	MicroRNA-21 regulates hTERT via PTEN in hypertrophic_scar_fibroblasts .
25084400	0	PTEN	103,107	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- regulates cellular proliferation , invasion , migration , and apoptosis by targeting PTEN , RECK and Bcl-2 in lung squamous_carcinoma , Gejiu City , China .
25357050	0	PTEN	76,80	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	expression|nmod|START_ENTITY regulating|dobj|expression affects|advcl|regulating affects|nsubj|END_ENTITY	MicroRNA-21 affects proliferation and apoptosis by regulating expression of PTEN in human keloid fibroblasts .
25603978	0	PTEN	31,35	MicroRNA-21	0,11	PTEN	MicroRNA-21	5728	406991	Gene	Gene	hTERT|nmod|START_ENTITY controls|dobj|hTERT controls|nsubj|END_ENTITY	MicroRNA-21 controls hTERT via PTEN in human colorectal_cancer cell proliferation .
26482612	0	PTEN	21,25	MicroRNA-221	0,12	PTEN	MicroRNA-221	5728	407006	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-221 targets PTEN to reduce the sensitivity of cervical_cancer cells to gefitinib through the PI3K/Akt signaling pathway .
26160225	0	PTEN	53,57	MicroRNA-23a	0,12	PTEN	MicroRNA-23a	5728	407010	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma .
26822433	0	PTEN	103,107	MicroRNA-29	0,11	PTEN	MicroRNA-29	5728	407021	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal_pigment_epithelial cells through PTEN .
25665754	0	PTEN	13,17	MicroRNA-29A	0,12	PTEN	MicroRNA-29A	50557(Tax:10116)	100314230(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY END_ENTITY|parataxis|modulates	MicroRNA-29A / PTEN pathway modulates neurite outgrowth in PC12 cells .
25253996	0	PTEN	80,84	MicroRNA-492	0,12	PTEN	MicroRNA-492	5728	574449	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|expression expression|amod|END_ENTITY	MicroRNA-492 expression promotes the progression of hepatic_cancer by targeting PTEN .
26499912	0	PTEN	104,108	MicroRNA-616	0,12	PTEN	MicroRNA-616	5728	693201	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-616 promotes the migration , invasion and epithelial-mesenchymal transition of HCC by targeting PTEN .
25058005	0	PTEN	21,25	Mir-21	14,20	PTEN	Mir-21	5728	406991	Gene	Gene	expression|compound|START_ENTITY modulates|nsubj|expression Alteration|parataxis|modulates Alteration|nmod|END_ENTITY	Alteration in Mir-21 / PTEN expression modulates gefitinib resistance in non-small_cell_lung_cancer .
14623898	0	PTEN	40,44	NF-kappaB	103,112	PTEN	NF-kappaB	5728	4790	Gene	Gene	START_ENTITY|nmod|nuclear_factor-kappaB nuclear_factor-kappaB|appos|END_ENTITY	Down-regulation of the tumor suppressor PTEN by the tumor_necrosis_factor-alpha / nuclear_factor-kappaB -LRB- NF-kappaB -RRB- - inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop .
19940030	0	PTEN	23,27	NF-kappaB	46,55	PTEN	NF-kappaB	5728	4790	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic_cancer cells .
14729949	0	PTEN	15,19	NF-kappa_B	34,44	PTEN	NF-kappa B	5728	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Suppression of PTEN expression by NF-kappa_B prevents apoptosis .
11668501	0	PTEN	39,43	NF2	28,31	PTEN	NF2	5728	4771	Gene	Gene	NRAS|dep|START_ENTITY NRAS|compound|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
18953692	0	PTEN	17,21	NFkappaB	34,42	PTEN	NFkappaB	5728	4790	Gene	Gene	targets|dobj|START_ENTITY targets|xcomp|regulate regulate|dobj|END_ENTITY	Fish oil targets PTEN to regulate NFkappaB for downregulation of anti-apoptotic genes in breast_tumor growth .
20060890	0	PTEN	36,40	NFkappaB	56,64	PTEN	NFkappaB	5728	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast_cancer cell growth .
16456542	0	PTEN	0,4	NHERF	38,43	PTEN	NHERF	5728	9368	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling .
18307411	0	PTEN	22,26	Nedd4	93,98	PTEN	Nedd4	5728	4734	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4 .
20807096	0	PTEN	0,4	P53	54,57	PTEN	P53	5728	7157	Gene	Gene	suppressor|compound|START_ENTITY plays|nsubj|suppressor plays|nmod|suppressor suppressor|compound|END_ENTITY	PTEN tumor suppressor plays less prognostic role than P53 tumor suppressor in diffuse_large_B-cell_lymphoma .
23729286	0	PTEN	39,43	P53	34,37	PTEN	P53	5728	7157	Gene	Gene	FAS|appos|START_ENTITY FAS|compound|END_ENTITY	`` Immunocytochemical expression of P53 , PTEN , FAS -LRB- CD95 -RRB- , P16INK4A and HPV L1 major capsid proteins in ThinPrep cervical samples with squamous_intraepithelial_lesions '' .
20049735	0	PTEN	30,34	PARP	53,57	PTEN	PARP	5728	142	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors .
20944090	0	PTEN	0,4	PARP	84,88	PTEN	PARP	5728	142	Gene	Gene	deficiency_in_endometrioid_endometrial_adenocarcinomas|compound|START_ENTITY predicts|nsubj|deficiency_in_endometrioid_endometrial_adenocarcinomas predicts|nmod|inhibitors inhibitors|compound|END_ENTITY	PTEN deficiency_in_endometrioid_endometrial_adenocarcinomas predicts sensitivity to PARP inhibitors .
16829519	0	PTEN	15,19	PCAF	0,4	PTEN	PCAF	5728	8850	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	PCAF modulates PTEN activity .
18239055	0	PTEN	18,22	PKC-alpha	79,88	PTEN	PKC-alpha	5728	5578	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic_cancer cells .
23129748	0	PTEN	14,18	PKD1	37,41	PTEN	PKD1	5728	5310	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Regulation of PTEN activity by p38 - PKD1 signaling in neutrophils confers inflammatory responses in the lung .
23117887	0	PTEN	52,56	PNUTS	0,5	PTEN	PNUTS	5728	5514	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	PNUTS functions as a proto-oncogene by sequestering PTEN .
17409395	0	PTEN	21,25	PRL-3	0,5	PTEN	PRL-3	5728	10879	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition .
22791713	0	PTEN	101,105	Phosphatase_of_regenerating_liver_2	0,35	PTEN	Phosphatase of regenerating liver 2	5728	8073	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Phosphatase_of_regenerating_liver_2 -LRB- PRL2 -RRB- is essential for placental development by down-regulating PTEN -LRB- Phosphatase_and_Tensin_Homologue_Deleted_on_Chromosome_10 -RRB- and activating Akt protein .
20610402	0	PTEN	35,39	Plexin-B1	14,23	PTEN	Plexin-B1	5728	5364	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Semaphorin_4D / Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity , inducing growth cone collapse in hippocampal neurons .
24706748	0	PTEN	60,64	Plk1	0,4	PTEN	Plk1	5728	5347	Gene	Gene	homolog|appos|START_ENTITY phosphorylates|dobj|homolog phosphorylates|nsubj|protein protein|amod|END_ENTITY	Plk1 protein phosphorylates phosphatase and tensin homolog -LRB- PTEN -RRB- and regulates its mitotic activity during the cell cycle .
25047839	0	PTEN	24,28	Plk1	0,4	PTEN	Plk1	19211(Tax:10090)	18817(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state .
20940307	0	PTEN	14,18	Plk3	45,49	PTEN	Plk3	19211(Tax:10090)	12795(Tax:10090)	Gene	Gene	stability|compound|START_ENTITY Regulation|nmod|stability Regulation|nmod|END_ENTITY	Regulation of PTEN stability and activity by Plk3 .
15782128	0	PTEN	136,140	RCC1	107,111	PTEN	RCC1	5728	1104	Gene	Gene	targets|nmod|START_ENTITY END_ENTITY|nmod|targets	Modulation of specific protein expression levels by PTEN : identification of AKAP121 , DHFR , G3BP , Rap1 , and RCC1 as potential targets of PTEN .
26403191	0	PTEN	0,4	RPA1	15,19	PTEN	RPA1	19211(Tax:10090)	68275(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PTEN regulates RPA1 and protects DNA replication forks .
26869029	0	PTEN	0,4	Rab7	84,88	PTEN	Rab7	5728	338382	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7 .
11250155	0	PTEN	0,4	SCF	114,117	PTEN	SCF	5728	4254	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27 -LRB- KIP1 -RRB- through the ubiquitin E3 ligase SCF -LRB- SKP2 -RRB- .
17438373	0	PTEN	86,90	SCF	14,17	PTEN	SCF	5728	4254	Gene	Gene	pathway|compound|START_ENTITY proteolysis|nmod|pathway E3|ccomp|proteolysis E3|nsubj|Regulation Regulation|nmod|ubiquitin ubiquitin|compound|END_ENTITY	Regulation of SCF -LRB- SKP2 -RRB- ubiquitin E3 ligase assembly and p27 -LRB- KIP1 -RRB- proteolysis by the PTEN pathway and cyclin_D1 .
20797623	0	PTEN	46,50	STAT3	0,5	PTEN	STAT3	5728	6774	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer .
12408227	0	PTEN	113,117	Skp2	93,97	PTEN	Skp2	5728	6502	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells .
19114034	0	PTEN	0,4	Sp1	75,78	PTEN	Sp1	5728	6667	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|advcl|decreasing decreasing|dobj|activity activity|nmod|END_ENTITY	PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1 .
22810004	0	PTEN	189,193	Sp1	119,122	PTEN	Sp1	5728	6667	Gene	Gene	chromosome|appos|START_ENTITY deleted|nmod|chromosome homolog|acl|deleted END_ENTITY|nmod|homolog	Estrogen receptor beta -LRB- ERb -RRB- produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 -LRB- PTEN -RRB- promoter gene .
23104175	0	PTEN	24,28	Sp1	11,14	PTEN	Sp1	5728	6667	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion .
23104175	0	PTEN	59,63	Sp1	11,14	PTEN	Sp1	5728	6667	Gene	Gene	binding|nmod|START_ENTITY promoter|amod|binding inhibits|nmod|promoter inhibits|nsubj|END_ENTITY	Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion .
26686089	0	PTEN	15,19	TBX2	0,4	PTEN	TBX2	5728	6909	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle .
23599148	0	PTEN	51,55	TGF-b	7,12	PTEN	TGF-b	5728	7040	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Active TGF-b signaling and decreased expression of PTEN separates angiosarcoma_of_bone from its soft tissue counterpart .
25787292	0	PTEN	96,100	TGF-b1	114,120	PTEN	TGF-b1	5728	7040	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	High concentrations of uric acid inhibit endothelial cell migration via miR-663 which regulates PTEN by targeting TGF-b1 .
26796257	0	PTEN	85,89	TGF-b1	0,6	PTEN	TGF-b1	5728	7040	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	TGF-b1 induces erlotinib resistance in non-small_cell_lung_cancer by down-regulating PTEN .
18239055	0	PTEN	18,22	TGF-beta	0,8	PTEN	TGF-beta	5728	7040	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic_cancer cells .
19940030	0	PTEN	23,27	TGF-beta	0,8	PTEN	TGF-beta	5728	7040	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic_cancer cells .
17334236	0	PTEN	22,26	TNF-alpha	0,9	PTEN	TNF-alpha	5728	7124	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells .
26657567	0	PTEN	0,4	TOP2A	16,21	PTEN	TOP2A	5728	7153	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	PTEN stabilizes TOP2A and regulates the DNA decatenation .
11668501	0	PTEN	39,43	TP53	33,37	PTEN	TP53	5728	7157	Gene	Gene	NRAS|dep|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
15707585	0	PTEN	21,25	TSP-1	47,52	PTEN	TSP-1	5728	7057	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid_carcinoma cells .
23082988	0	PTEN	15,19	Tbx3	0,4	PTEN	Tbx3	5728	6926	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Tbx3 represses PTEN and is over-expressed in head and neck_squamous_cell_carcinoma .
16294307	0	PTEN	123,127	U-87	147,151	PTEN	U-87	5728	641648	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells .
15579911	0	PTEN	18,22	Vinculin	0,8	PTEN	Vinculin	5728	7414	Gene	Gene	level|compound|START_ENTITY controls|dobj|level controls|nsubj|END_ENTITY	Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2 .
19473982	0	PTEN	57,61	X-linked_inhibitor_of_apoptosis_protein	0,39	PTEN	X-linked inhibitor of apoptosis protein	19211(Tax:10090)	11798(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- regulates PTEN ubiquitination , content , and compartmentalization .
19483472	0	PTEN	0,4	YY1	20,23	PTEN	YY1	5728	7528	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|END_ENTITY	PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null_renal-cell_carcinoma .
16821090	0	PTEN	0,4	adrenomedullin	14,28	PTEN	adrenomedullin	5728	133	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	PTEN inhibits adrenomedullin expression and function in brain_tumor cells .
12914534	0	PTEN	4,8	androgen_receptor	53,70	PTEN	androgen receptor	5728	367	Gene	Gene	suppressor|compound|START_ENTITY modulator|nsubj|suppressor modulator|nmod|activity activity|compound|END_ENTITY	The PTEN tumor suppressor is a negative modulator of androgen_receptor transcriptional activity .
15205473	0	PTEN	45,49	androgen_receptor	14,31	PTEN	androgen receptor	5728	367	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of androgen_receptor signaling by PTEN -LRB- phosphatase and tensin homolog deleted on chromosome 10 -RRB- tumor suppressor through distinct mechanisms in prostate_cancer cells .
19074551	0	PTEN	15,19	androgen_receptor	35,52	PTEN	androgen receptor	5728	367	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|N N|compound|END_ENTITY	FoxO1 mediates PTEN suppression of androgen_receptor N - and C-terminal interactions and coactivator recruitment .
21532617	0	PTEN	27,31	androgen_receptor	46,63	PTEN	androgen receptor	5728	367	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of PTEN expression by androgen_receptor in prostate and breast_cancers .
22021428	0	PTEN	27,31	androgen_receptor	71,88	PTEN	androgen receptor	5728	367	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|preventing preventing|dobj|translocation translocation|nmod|END_ENTITY	GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen_receptor and by androgen-independent suppression of PTEN transcription in breast_cancer .
26285813	0	PTEN	47,51	androgen_receptor	21,38	PTEN	androgen receptor	19211(Tax:10090)	11835(Tax:10090)	Gene	Gene	inactivation|compound|START_ENTITY promote|dobj|inactivation promote|nsubj|actions actions|nmod|END_ENTITY	Androgen actions via androgen_receptor promote PTEN inactivation induced uterine cancer .
22198171	0	PTEN	92,96	angiotensin_II	58,72	PTEN	angiotensin II	50557(Tax:10116)	24179(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY END_ENTITY|nmod|stimulation	Angiotensin - -LRB- 1-7 -RRB- attenuates the chronotropic response to angiotensin_II via stimulation of PTEN in the spontaneously hypertensive rat neurons .
22887358	0	PTEN	14,18	angiotensin_II	46,60	PTEN	angiotensin II	5728	183	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of PTEN expression and activity by angiotensin_II induces proliferation and migration of vascular smooth muscle cells .
20079187	0	PTEN	37,41	beta-catenin	15,27	PTEN	beta-catenin	5728	1499	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	-LSB- Expression of beta-catenin , Glut-1 , PTEN proteins in uterine endometrioid_adenocarcinoma and its precursor lesions -RSB- .
16676006	0	PTEN	51,55	c-Jun	0,5	PTEN	c-Jun	5728	3725	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	c-Jun promotes cellular survival by suppression of PTEN .
17235455	0	PTEN	0,4	c-fos	37,42	PTEN	c-fos	5728	2353	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway .
10415336	0	PTEN	0,4	c-myc	33,38	PTEN	c-myc	5728	4609	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	PTEN transcriptionally modulates c-myc gene expression in human breast_carcinoma cells and is involved in cell growth regulation .
26367448	0	PTEN	25,29	caspase-3	15,24	PTEN	caspase-3	5728	836	Gene	Gene	signaling|nsubj|START_ENTITY Involvement|parataxis|signaling Involvement|nmod|END_ENTITY	Involvement of caspase-3 / PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells .
26367448	0	PTEN	25,29	caspase-3	15,24	PTEN	caspase-3	5728	836	Gene	Gene	signaling|nsubj|START_ENTITY Involvement|parataxis|signaling Involvement|nmod|END_ENTITY	Involvement of caspase-3 / PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells .
20395445	0	PTEN	36,40	caveolin-1	11,21	PTEN	caveolin-1	5728	857	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Pathologic caveolin-1 regulation of PTEN in idiopathic_pulmonary_fibrosis .
10209098	0	PTEN	112,116	daf-18	67,73	PTEN	daf-18	5728	176869(Tax:6239)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Regulation of dauer larva development in Caenorhabditis_elegans by daf-18 , a homologue of the tumour suppressor PTEN .
10400703	0	PTEN	0,4	focal_adhesion_kinase	23,44	PTEN	focal adhesion kinase	19211(Tax:10090)	14083(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	PTEN interactions with focal_adhesion_kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway .
19501627	0	PTEN	0,4	focal_adhesion_kinase	50,71	PTEN	focal adhesion kinase	19211(Tax:10090)	14083(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	PTEN and SHIP2 regulates PI3K/Akt pathway through focal_adhesion_kinase .
9927060	0	PTEN	17,21	focal_adhesion_kinase	102,123	PTEN	focal adhesion kinase	5728	5747	Gene	Gene	inhibition|compound|START_ENTITY inhibition|dep|involvement involvement|nmod|END_ENTITY	Tumor suppressor PTEN inhibition of cell invasion , migration , and growth : differential involvement of focal_adhesion_kinase and p130Cas .
12632503	0	PTEN	31,35	hypoxia-inducible_factor-1_alpha	37,69	PTEN	hypoxia-inducible factor-1 alpha	5728	3091	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and significance of PTEN , hypoxia-inducible_factor-1_alpha in colorectal_adenoma and adenocarcinoma .
18268343	0	PTEN	0,4	hypoxia-inducible_factor_1	30,56	PTEN	hypoxia-inducible factor 1	5728	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	PTEN regulates p300-dependent hypoxia-inducible_factor_1 transcriptional activity through Forkhead transcription factor 3a -LRB- FOXO3a -RRB- .
12414639	0	PTEN	63,67	mTOR	14,18	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	status|compound|START_ENTITY conferred|nmod|status conferred|nsubj|Inhibitors Inhibitors|nmod|resistance resistance|compound|END_ENTITY	Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate_cancer cells .
18332865	0	PTEN	15,19	mTOR	118,122	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	increases|compound|START_ENTITY Suppression|nmod|increases breast_cancer|nsubj|Suppression breast_cancer|advcl|conferring conferring|nmod|inhibitors inhibitors|compound|END_ENTITY	Suppression of PTEN function increases breast_cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors .
18787170	0	PTEN	55,59	mTOR	14,18	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	targets|nmod|START_ENTITY targets|dobj|END_ENTITY	FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression .
18826385	0	PTEN	34,38	mTOR	47,51	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas .
19115995	0	PTEN	0,4	mTOR	74,78	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	START_ENTITY|acl|inhibiting inhibiting|advcl|regulating regulating|dobj|END_ENTITY	PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway .
20636791	0	PTEN	29,33	mTOR	53,57	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Immunohistochemical study of PTEN and phosphorylated mTOR proteins in familial and sporadic_invasive_breast_carcinomas .
21185267	0	PTEN	0,4	mTOR	63,67	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	deletion|compound|START_ENTITY prevents|nsubj|deletion prevents|advcl|activating activating|dobj|END_ENTITY	PTEN deletion prevents ischemic brain_injury by activating the mTOR signaling pathway .
22080063	0	PTEN	5,9	mTOR	105,109	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	loss|compound|START_ENTITY involvement|nmod|loss involvement|nmod|pathway pathway|compound|END_ENTITY	From PTEN loss of expression to RICTOR role in smooth muscle differentiation : complex involvement of the mTOR pathway in leiomyosarcomas and pleomorphic_sarcomas .
23205120	0	PTEN	66,70	mTOR	34,38	PTEN	mTOR	5728	21977(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|expression expression|nmod|END_ENTITY	Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric_carcinoma .
25266877	0	PTEN	79,83	mTOR	10,14	PTEN	mTOR	19211(Tax:10090)	21977(Tax:10090)	Gene	Gene	nude_mice|nmod|START_ENTITY status|amod|nude_mice inhibitors|nmod|status inhibitors|nsubj|Effect Effect|nmod|END_ENTITY	Effect of mTOR inhibitors in nude_mice with endometrial_carcinoma and variable PTEN expression status .
26097565	0	PTEN	83,87	miR-106a	0,8	PTEN	miR-106a	5728	406899	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-106a promotes growth and metastasis of non-small_cell_lung_cancer by targeting PTEN .
22995297	0	PTEN	18,22	miR-1297	0,8	PTEN	miR-1297	5728	100302187	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	miR-1297 mediates PTEN expression and contributes to cell progression in LSCC .
26622832	0	PTEN	8,12	miR-17-5p	46,55	PTEN	miR-17-5p	5728	406952	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduced PTEN expression and overexpression of miR-17-5p , -19 a-3p , -19 b-3p , -21 -5 p , -130 b-3p , -221 -3 p and -222 -3 p by glioblastoma stem-like cells following irradiation .
23856247	0	PTEN	16,20	miR-205	0,7	PTEN	miR-205	5728	406988	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small_cell_lung_cancer .
19473551	0	PTEN	38,42	miR-21	14,20	PTEN	miR-21	5728	406991	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of miR-21 and its targets -LRB- PTEN , PDCD4 , TM1 -RRB- in flat_epithelial_atypia_of_the_breast in relation to ductal_carcinoma_in_situ and invasive_carcinoma .
20223231	0	PTEN	48,52	miR-21	13,19	PTEN	miR-21	5728	406991	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|MicroRNA-21 MicroRNA-21|dep|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- represses tumor suppressor PTEN and promotes growth and invasion in non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
20797623	0	PTEN	46,50	miR-21	20,26	PTEN	miR-21	5728	406991	Gene	Gene	activation|nmod|START_ENTITY activation|acl|END_ENTITY	STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer .
21187093	0	PTEN	66,70	miR-21	15,21	PTEN	miR-21	5728	406991	Gene	Gene	expression|compound|START_ENTITY regulating|dobj|expression daunorubicin|advcl|regulating resistance|acl|daunorubicin END_ENTITY|nmod|resistance	Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line .
22162762	0	PTEN	0,4	miR-21	15,21	PTEN	miR-21	5728	406991	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|processing processing|amod|END_ENTITY	PTEN modulates miR-21 processing via RNA-regulatory protein RNH1 .
22761812	0	PTEN	140,144	miR-21	14,20	PTEN	miR-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY reverses|advcl|targeting reverses|nsubj|Antagonism Antagonism|nmod|END_ENTITY	Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN .
22956424	0	PTEN	140,144	miR-21	13,19	PTEN	miR-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|expression expression|amod|MicroRNA-21 MicroRNA-21|dep|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- expression promotes growth , metastasis , and chemo - or radioresistance in non-small_cell_lung_cancer cells by targeting PTEN .
23466500	0	PTEN	74,78	miR-21	0,6	PTEN	miR-21	5728	406991	Gene	Gene	regulating|dobj|START_ENTITY confers|advcl|regulating confers|nsubj|END_ENTITY	miR-21 confers cisplatin resistance in gastric_cancer cells by regulating PTEN .
23894315	0	PTEN	38,42	miR-21	95,101	PTEN	miR-21	5728	406991	Gene	Gene	expression|compound|START_ENTITY restores|dobj|expression restores|nmod|END_ENTITY	Difluorinated-curcumin _ -LRB- CDF -RRB- restores PTEN expression in colon_cancer cells by down-regulating miR-21 .
24221338	0	PTEN	19,23	miR-21	61,67	PTEN	miR-21	5728	406991	Gene	Gene	expression|compound|START_ENTITY Down-regulation|nmod|expression modulated|nsubj|Down-regulation modulated|nmod|contributes contributes|amod|END_ENTITY	Down-regulation of PTEN expression modulated by dysregulated miR-21 contributes to the progression of esophageal_cancer .
25084400	0	PTEN	103,107	miR-21	13,19	PTEN	miR-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|MicroRNA-21 MicroRNA-21|dep|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- regulates cellular proliferation , invasion , migration , and apoptosis by targeting PTEN , RECK and Bcl-2 in lung squamous_carcinoma , Gejiu City , China .
25365510	0	PTEN	118,122	miR-21	14,20	PTEN	miR-21	5728	406991	Gene	Gene	Gene|compound|START_ENTITY Apoptosis|nmod|Gene Apoptosis|nsubj|Activation Activation|nmod|Proliferation Proliferation|amod|END_ENTITY	Activation of miR-21 by STAT3 Induces Proliferation and Suppresses Apoptosis in Nasopharyngeal_Carcinoma by Targeting PTEN Gene .
25451263	0	PTEN	104,108	miR-21	10,16	PTEN	miR-21	5728	406991	Gene	Gene	upregulation|nmod|START_ENTITY Sup-b15|nmod|upregulation Sup-b15|dep|Targeting Targeting|dobj|sensitizes sensitizes|amod|END_ENTITY	Targeting miR-21 sensitizes Ph + ALL Sup-b15 cells to imatinib-induced apoptosis through upregulation of PTEN .
25963606	0	PTEN	113,117	miR-21	18,24	PTEN	miR-21	5728	406991	Gene	Gene	inhibition|nmod|START_ENTITY cells|nmod|inhibition proliferation|nmod|cells promotes|dobj|proliferation promotes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of miR-21 promotes the proliferation and migration of cervical_cancer cells via the inhibition of PTEN .
26415649	0	PTEN	68,72	miR-21	0,6	PTEN	miR-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-21 promotes renal_fibrosis in diabetic_nephropathy by targeting PTEN and SMAD7 .
26787105	0	PTEN	25,29	miR-21	121,127	PTEN	miR-21	5728	406991	Gene	Gene	status|compound|START_ENTITY effect|nmod|status effect|dep|END_ENTITY	The prognostic effect of PTEN expression status in colorectal_cancer development and evaluation of factors affecting it : miR-21 and promoter methylation .
24295494	0	PTEN	96,100	miR-221	0,7	PTEN	miR-221	19211(Tax:10090)	723827(Tax:10090)	Gene	Gene	status|compound|START_ENTITY independent|nmod|status activating|xcomp|independent confers|advcl|activating confers|nsubj|222 222|amod|END_ENTITY	miR-221 / 222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status .
26397386	0	PTEN	114,118	miR-221	0,7	PTEN	miR-221	5728	407006	Gene	Gene	downregulation|nmod|START_ENTITY increases|nmod|downregulation increases|nsubj|END_ENTITY	miR-221 increases osteosarcoma cell proliferation , invasion and migration partly through the downregulation of PTEN .
26501139	0	PTEN	69,73	miR-221	0,7	PTEN	miR-221	5728	407006	Gene	Gene	Epithelial-Mesenchymal|nmod|START_ENTITY Epithelial-Mesenchymal|nsubj|Promotes Promotes|amod|END_ENTITY	miR-221 Promotes Epithelial-Mesenchymal Transition through Targeting PTEN and Forms a Positive Feedback Loop with b-catenin/c-Jun Signaling Pathway in Extra-Hepatic_Cholangiocarcinoma .
25361012	0	PTEN	52,56	miR-26a	0,7	PTEN	miR-26a	5728	407015	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|amod|END_ENTITY	miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic_lymphocytic_leukemia , but not PTEN mutation or promoter methylation .
26772880	0	PTEN	103,107	miR-367	0,7	PTEN	miR-367	5728	442912	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	miR-367 promotes proliferation and invasion of hepatocellular_carcinoma cells by negatively regulating PTEN .
20006626	0	PTEN	37,41	miR-494	14,21	PTEN	miR-494	5728	574452	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo -LRB- a -RRB- pyrene-trans-7 ,8 - dihydrodiol-9 ,10 - epoxide .
26045065	0	PTEN	137,141	miR-494	0,7	PTEN	miR-494	5728	574452	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-494 promotes cell proliferation , migration and invasion , and increased sorafenib resistance in hepatocellular_carcinoma by targeting PTEN .
26686085	0	PTEN	63,67	miR-494	91,98	PTEN	miR-494	5728	574452	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|inhibition inhibition|nmod|END_ENTITY	Tumor-suppressor NFkB2_p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494 .
27040768	0	PTEN	94,98	miR-543	0,7	PTEN	miR-543	5728	100126335	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	miR-543 promotes proliferation and invasion of non-small_cell_lung_cancer cells by inhibiting PTEN .
19072831	0	PTEN	99,103	microRNA-21	109,120	PTEN	microRNA-21	5728	406991	Gene	Gene	phosphatase|appos|START_ENTITY phosphatase|nmod|up-regulation up-regulation|amod|END_ENTITY	Unsaturated fatty_acids inhibit the expression of tumor suppressor phosphatase and tensin homolog -LRB- PTEN -RRB- via microRNA-21 up-regulation in hepatocytes .
21104017	0	PTEN	34,38	microRNA-21	8,19	PTEN	microRNA-21	5728	406991	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of microRNA-21 and effect on PTEN in Kazakh 's esophageal_squamous_cell_carcinoma .
22213145	0	PTEN	79,83	microRNA-21	108,119	PTEN	microRNA-21	5728	406991	Gene	Gene	increases|dobj|START_ENTITY increases|advcl|decreasing decreasing|xcomp|END_ENTITY	Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21 .
22267008	0	PTEN	85,89	microRNA-21	0,11	PTEN	microRNA-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	microRNA-21 promotes tumor proliferation and invasion in gastric_cancer by targeting PTEN .
22770403	0	PTEN	0,4	microRNA-21	40,51	PTEN	microRNA-21	5728	406991	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma .
22879939	0	PTEN	37,41	microRNA-21	16,27	PTEN	microRNA-21	5728	406991	Gene	Gene	START_ENTITY|nsubj|utilizes utilizes|amod|END_ENTITY	TGFb-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion .
23226804	0	PTEN	74,78	microRNA-21	0,11	PTEN	microRNA-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY contributes|advcl|targeting contributes|nsubj|overexpression overexpression|amod|END_ENTITY	microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid_endometrial_cancer .
24154840	0	PTEN	16,20	microRNA-21	4,15	PTEN	microRNA-21	5728	406991	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	The microRNA-21 / PTEN pathway regulates the sensitivity of HER2-positive_gastric_cancer cells to trastuzumab .
25845681	0	PTEN	113,117	microRNA-21	88,99	PTEN	microRNA-21	5728	406991	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	Icariin regulates the proliferation and apoptosis of human ovarian_cancer cells through microRNA-21 by targeting PTEN , RECK and Bcl-2 .
26230405	0	PTEN	75,79	microRNA-21	0,11	PTEN	microRNA-21	5728	406991	Gene	Gene	Talk|nmod|START_ENTITY Talk|nsubj|Proliferation Proliferation|amod|END_ENTITY	microRNA-21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder_Cancer .
24315818	0	PTEN	82,86	microRNA-301a	12,25	PTEN	microRNA-301a	5728	407027	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Upregulated microRNA-301a in breast_cancer promotes tumor metastasis by targeting PTEN and activating Wnt/b-catenin signaling .
23826727	0	PTEN	0,4	p16ink4a	82,90	PTEN	p16ink4a	19211(Tax:10090)	12578(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|END_ENTITY	PTEN controls b-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a .
23336417	0	PTEN	43,47	p27	38,41	PTEN	p27	5728	10671	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	-LSB- The expression and meanning of Skp2 , p27 , PTEN proteins in non-Hodgkin B-cell lymphoma_of_ocular_adnexa -RSB- .
10797439	0	PTEN	26,30	p53	32,35	PTEN	p53	5728	7157	Gene	Gene	INK4A|compound|START_ENTITY INK4A|dep|END_ENTITY	Investigation of germline PTEN , p53 , p16 -LRB- INK4A -RRB- / p14 -LRB- ARF -RRB- , and CDK4 alterations in familial_glioma .
11545734	0	PTEN	14,18	p53	36,39	PTEN	p53	5728	7157	Gene	Gene	Regulation|nmod|START_ENTITY transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of PTEN transcription by p53 .
11729185	0	PTEN	0,4	p53	14,17	PTEN	p53	5728	7157	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy .
12217521	0	PTEN	4,8	p53	16,19	PTEN	p53	5728	7157	Gene	Gene	START_ENTITY|appos|tumor tumor|compound|END_ENTITY	The PTEN , Mdm2 , p53 tumor suppressor-oncoprotein network .
12620407	0	PTEN	0,4	p53	32,35	PTEN	p53	19211(Tax:10090)	22060(Tax:10090)	Gene	Gene	suppressor|compound|START_ENTITY regulates|nsubj|suppressor regulates|dobj|levels levels|compound|END_ENTITY	PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and - independent mechanisms .
12839924	0	PTEN	56,60	p53	91,94	PTEN	p53	5728	7157	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|advcl|inhibiting inhibiting|dobj|function function|nmod|END_ENTITY	Hepatitis_B_Virus X protein modulates the expression of PTEN by inhibiting the function of p53 , a transcriptional activator in liver cells .
12839945	0	PTEN	0,4	p53	63,66	PTEN	p53	5728	7157	Gene	Gene	START_ENTITY|dep|inhibitors inhibitors|dep|END_ENTITY	PTEN and phosphatidylinositol 3 ' - kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis : evidence for an effect on the tumor and endothelial compartment .
14559824	0	PTEN	0,4	p53	72,75	PTEN	p53	5728	7157	Gene	Gene	reverses|nsubj|START_ENTITY reverses|advcl|interacting interacting|nmod|END_ENTITY	PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute_lymphoblastic_leukemia cells .
16061640	0	PTEN	39,43	p53	25,28	PTEN	p53	19211(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|Loss Loss|nmod|END_ENTITY	Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator_protein_1 and nuclear factor kappaB induced by UV radiation .
16424003	0	PTEN	0,4	p53	54,57	PTEN	p53	5728	7157	Gene	Gene	autoregulates|nsubj|START_ENTITY autoregulates|nmod|stabilization stabilization|nmod|END_ENTITY	PTEN autoregulates its expression by stabilization of p53 in a phosphatase-independent manner .
16916644	0	PTEN	65,69	p53	46,49	PTEN	p53	5728	7157	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|nsubj|insights insights|nmod|maintenance maintenance|nmod|END_ENTITY	Mechanistic insights into maintenance of high p53 acetylation by PTEN .
17409411	0	PTEN	40,44	p53	59,62	PTEN	p53	19211(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The regulation of AMPK beta1 , TSC2 , and PTEN expression by p53 : stress , cell and tissue specificity , and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways .
17982625	0	PTEN	41,45	p53	65,68	PTEN	p53	5728	7157	Gene	Gene	START_ENTITY|appos|overexpression overexpression|nmod|END_ENTITY	Down-regulation of tumor suppressor gene PTEN , overexpression of p53 , plus high proliferating_cell_nuclear_antigen index predict poor patient outcome of hepatocellular_carcinoma after resection .
18339852	0	PTEN	0,4	p53	71,74	PTEN	p53	5728	7157	Gene	Gene	has|nsubj|START_ENTITY has|dobj|properties properties|nmod|setting setting|nmod|mutations mutations|compound|END_ENTITY	PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations .
20926450	0	PTEN	93,97	p53	164,167	PTEN	p53	5728	7157	Gene	Gene	motifs|nmod|START_ENTITY occurring|nmod|motifs lead|csubj|occurring lead|xcomp|oxidative oxidative|dobj|damage damage|nmod|DNA DNA|acl|associated associated|nmod|END_ENTITY	Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53 .
22999923	0	PTEN	87,91	p53	18,21	PTEN	p53	5728	7157	Gene	Gene	pathway|compound|START_ENTITY promotes|nmod|pathway promotes|nsubj|mutation mutation|nmod|gene gene|compound|END_ENTITY	R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3b / PTEN pathway .
23613387	0	PTEN	0,4	p53	17,20	PTEN	p53	5728	7157	Gene	Gene	MAPK|nsubj|START_ENTITY MAPK|dobj|END_ENTITY	PTEN , Akt , MAPK , p53 and p95 expression to predict trastuzumab resistance in HER2 positive breast_cancer .
24718924	0	PTEN	21,25	p53	41,44	PTEN	p53	5728	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The tumor suppressor PTEN interacts with p53 in hereditary_cancer -LRB- Review -RRB- .
25888633	0	PTEN	76,80	p53	98,101	PTEN	p53	5728	7157	Gene	Gene	START_ENTITY|advmod|irrespective irrespective|nmod|status status|compound|END_ENTITY	HDACi inhibits_liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN , irrespective of p53 mutational status .
25888633	0	PTEN	76,80	p53	98,101	PTEN	p53	5728	7157	Gene	Gene	START_ENTITY|advmod|irrespective irrespective|nmod|status status|compound|END_ENTITY	HDACi inhibits_liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN , irrespective of p53 mutational status .
19114034	0	PTEN	0,4	p75NTR	19,25	PTEN	p75NTR	5728	4804	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1 .
19635806	0	PTEN	37,41	p85	0,3	PTEN	p85	5728	5296	Gene	Gene	Associates|nmod|START_ENTITY Associates|amod|END_ENTITY	p85 Associates with unphosphorylated PTEN and the PTEN-associated complex .
15849504	0	PTEN	78,82	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	84,140	PTEN	phosphatase and tensin homolog deleted on chromosome ten	5728	5728	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|appos|END_ENTITY	Gastrin-releasing_peptide-induced down-regulation of tumor suppressor protein PTEN -LRB- phosphatase_and_tensin_homolog_deleted_on_chromosome_ten -RRB- in neuroblastomas .
16418168	0	PTEN	17,21	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	23,79	PTEN	phosphatase and tensin homolog deleted on chromosome ten	5728	5728	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of PTEN -LRB- phosphatase_and_tensin_homolog_deleted_on_chromosome_ten -RRB- mediates p38 MAPK stress signal-induced inhibition of insulin signaling .
25012292	0	PTEN	77,81	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	19,75	PTEN	phosphatase and tensin homolog deleted on chromosome ten	100156264(Tax:9823)	100156264(Tax:9823)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	The involvement of phosphatase_and_tensin_homolog_deleted_on_chromosome_ten -LRB- PTEN -RRB- in the regulation of inflammation following coronary microembolization .
16107342	0	PTEN	86,90	phosphatase_and_tensin_homologue	52,84	PTEN	phosphatase and tensin homologue	5728	5728	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Cooperative phosphorylation of the tumor suppressor phosphatase_and_tensin_homologue -LRB- PTEN -RRB- by casein kinases and glycogen_synthase_kinase_3beta .
24588644	0	PTEN	50,54	phosphatase_and_tensin_homologue	16,48	PTEN	phosphatase and tensin homologue	5728	5728	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Interactions of phosphatase_and_tensin_homologue -LRB- PTEN -RRB- proteins with phosphatidylinositol_phosphates : insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase .
24830779	0	PTEN	48,52	phosphatase_and_tensin_homologue	14,46	PTEN	phosphatase and tensin homologue	5728	5728	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phosphatase_and_tensin_homologue -LRB- PTEN -RRB- in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles .
17097286	0	PTEN	19,23	phosphatase_and_tensin_homologue_deleted_on_chromosome_ten	25,83	PTEN	phosphatase and tensin homologue deleted on chromosome ten	5728	5728	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Phosphorylation of PTEN -LRB- phosphatase_and_tensin_homologue_deleted_on_chromosome_ten -RRB- protein is enhanced in human fibromyomatous uteri .
16842970	0	PTEN	43,47	protein_kinase_B	14,30	PTEN	protein kinase B	5728	2185	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of protein_kinase_B activity by PTEN and SHIP2 in human prostate-derived cell lines .
19206163	0	PTEN	58,62	transforming_growth_factor-beta1	66,98	PTEN	transforming growth factor-beta1	5728	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Post-transcriptional and post-translational regulation of PTEN by transforming_growth_factor-beta1 .
17069699	0	PTEN	36,40	tumor_suppressor	14,30	PTEN	tumor suppressor	5728	7248	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	-LSB- Mutations of tumor_suppressor gene PTEN mutations in hepatocellular_carcinoma and its implications in tumor proliferation and apoptosis -RSB- .
23303188	0	PTEN-induced_putative_kinase_1	27,57	PINK1	20,25	PTEN-induced putative kinase 1	PINK1	65018	65018	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Characterization of PINK1 -LRB- PTEN-induced_putative_kinase_1 -RRB- mutations associated with Parkinson_disease in mammalian cells and Drosophila .
16627590	0	PTG	55,58	protein_targeting_to_glycogen	24,53	PTG	protein targeting to glycogen	53412(Tax:10090)	53412(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the mouse protein_targeting_to_glycogen -LRB- PTG -RRB- promoter by the FoxA2 forkhead protein and by 3 ' ,5 ' - cyclic_adenosine_5 ' - monophosphate in H4IIE hepatoma cells .
9242697	0	PTG	39,42	protein_targeting_to_glycogen	8,37	PTG	protein targeting to glycogen	5507	5507	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of protein_targeting_to_glycogen -LRB- PTG -RRB- in the regulation of protein phosphatase-1 activity .
22370065	0	PTGDS	54,59	prostaglandin_D2_synthase	27,52	PTGDS	prostaglandin D2 synthase	5730	5730	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of prostaglandin_D2_synthase -LRB- PTGDS -RRB- in patients with attention_deficit-hyperactivity_disorder and bipolar_disorder .
10618379	0	PTGF-beta	0,9	p53	86,89	PTGF-beta	p53	9518	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	PTGF-beta , a type beta transforming growth factor -LRB- TGF-beta -RRB- superfamily member , is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway .
24694232	0	PTGS1	111,116	cyclooxygenase_1_and_2	87,109	PTGS1	cyclooxygenase 1 and 2	5742	5742;5743	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Gene variants and haplotypes modifying transcription factor binding sites in the human cyclooxygenase_1_and_2 -LRB- PTGS1 and PTGS2 -RRB- genes .
17578436	0	PTGS2	81,86	COX-2	69,74	PTGS2	COX-2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of functional gene variants in the regulatory regions of COX-2 gene -LRB- PTGS2 -RRB- with nonmelanoma_skin_cancer after organ transplantation .
18085997	0	PTGS2	51,56	COX-2	39,44	PTGS2	COX-2	5743	4513	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Pyrosequencing of polymorphisms in the COX-2 gene -LRB- PTGS2 -RRB- with reported clinical relevance .
20378913	0	PTGS2	47,52	COX-2	41,46	PTGS2	COX-2	5743	4513	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The -LRB- -765 _ G _ > _ C -RRB- promoter variant of the COX-2 / PTGS2 gene is associated with a lower risk for end-stage hip and knee_osteoarthritis .
23810915	0	PTGS2	0,5	Cyclooxygenase-2	7,23	PTGS2	Cyclooxygenase-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	PTGS2 -LRB- Cyclooxygenase-2 -RRB- expression and survival among colorectal_cancer patients : a systematic review .
20826536	0	PTGS2	37,42	NFKB	82,86	PTGS2	NFKB	29527(Tax:10116)	309165(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Prostaglandin_F2a -LRB- PGF2a -RRB- stimulates PTGS2 expression and PGF2a synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats .
25166592	0	PTGS2	11,16	PTGS2	30,35	PTGS2	PTGS2	5743	5743	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Intestinal PTGS2 mRNA levels , PTGS2 gene polymorphisms , and colorectal_carcinogenesis .
25166592	0	PTGS2	30,35	PTGS2	11,16	PTGS2	PTGS2	5743	5743	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Intestinal PTGS2 mRNA levels , PTGS2 gene polymorphisms , and colorectal_carcinogenesis .
12920574	0	PTGS2	74,79	cyclooxygenase-2	51,67	PTGS2	cyclooxygenase-2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a promoter variant in the inducible cyclooxygenase-2 gene -LRB- PTGS2 -RRB- with type_2_diabetes_mellitus in Pima Indians .
16489098	0	PTGS2	22,27	cyclooxygenase-2	4,20	PTGS2	cyclooxygenase-2	5743	5743	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	The cyclooxygenase-2 -LRB- PTGS2 -RRB- 8473T > C polymorphism is associated with breast_cancer risk .
21481131	0	PTGS2	67,72	cyclooxygenase_2	37,53	COX-2	cyclooxygenase 2	5743	5743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Associations between variants in the cyclooxygenase_2 enzyme gene -LRB- PTGS2 -RRB- and development of benign_prostate_enlargement .
24423291	0	PTGS2	70,75	prostaglandin-endoperoxidase_synthase_2	29,68	PTGS2	prostaglandin-endoperoxidase synthase 2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hormonal therapy deregulates prostaglandin-endoperoxidase_synthase_2 -LRB- PTGS2 -RRB- expression in endometriotic tissues .
16553209	0	PTGS2	68,73	prostaglandin-endoperoxide_synthase_2	29,66	PTGS2	prostaglandin-endoperoxide synthase 2	397590(Tax:9823)	397590(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation of porcine prostaglandin-endoperoxide_synthase_2 -LRB- PTGS2 -RRB- gene and its association with reproductive traits in an Erhualian x Duroc F2 population .
8327369	0	PTH	102,105	EPO	72,75	PTH	EPO	5741	2056	Gene	Gene	erythropoietin|appos|START_ENTITY erythropoietin|appos|END_ENTITY	-LSB- Effect of immunosuppression method on levels of plasma erythropoietin -LRB- EPO -RRB- and parathyroid_hormone -LRB- PTH -RRB- during acute_graft_rejection in kidney transplantation -LRB- KTP -RRB- -RSB- .
18627264	0	PTH	23,26	EphrinB2	0,8	PTH	EphrinB2	19226(Tax:10090)	13642(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	EphrinB2 regulation by PTH and PTHrP revealed by molecular profiling in differentiating osteoblasts .
21806973	0	PTH	37,40	FGF2	70,74	PTH	FGF2	19226(Tax:10090)	14173(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression .
26925062	0	PTH	67,70	IL-17	12,17	PTH	IL-17	19226(Tax:10090)	16171(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Cells Cells|compound|END_ENTITY	The Role of IL-17 and TH17 Cells in the Bone Catabolic Activity of PTH .
25088803	0	PTH	21,24	N-cadherin	0,10	PTH	N-cadherin	19226(Tax:10090)	12558(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	N-cadherin Restrains PTH Activation of Lrp6/b-catenin Signaling and Osteoanabolic Action .
10784412	0	PTH	169,172	PTH	75,78	PTH	PTH	5741	5741	Gene	Gene	polymorphism|nmod|START_ENTITY polymorphism|nmod|intron intron|nmod|gene gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10784412	0	PTH	75,78	PTH	169,172	PTH	PTH	5741	5741	Gene	Gene	gene|appos|START_ENTITY intron|nmod|gene polymorphism|nmod|intron polymorphism|nmod|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
16460905	0	PTH	41,44	PTH	66,69	PTH	PTH	5741	5741	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Positive correlation of serum bio-intact PTH -LRB- 1-84 -RRB- but not intact PTH with parathyroid gland size in hemodialysis patients .
16460905	0	PTH	66,69	PTH	41,44	PTH	PTH	5741	5741	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Positive correlation of serum bio-intact PTH -LRB- 1-84 -RRB- but not intact PTH with parathyroid gland size in hemodialysis patients .
1854870	0	PTH	33,36	PTH	54,57	PTH	PTH	5741	5741	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative study between intact PTH and fragments of PTH in patients on hemodialysis and CAPD .
1854870	0	PTH	54,57	PTH	33,36	PTH	PTH	5741	5741	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative study between intact PTH and fragments of PTH in patients on hemodialysis and CAPD .
10784412	0	PTH	75,78	PTH-related_peptide	80,99	PTH	PTH-related peptide	5741	5744	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
9075739	0	PTH	95,98	PTH-related_peptide	100,119	PTH	PTH-related peptide	5741	5744	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
20501677	0	PTH	131,134	PTH-related_peptide_receptor	60,88	PTH	PTH-related peptide receptor	19226(Tax:10090)	19228(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Phospholipase C signaling via the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide_receptor is essential for normal bone responses to PTH .
10499494	0	PTH	78,81	PTH2_receptor	126,139	PTH	PTH2 receptor	5741	81753(Tax:10116)	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	Comparison of rat and human parathyroid_hormone_2 -LRB- PTH2 -RRB- receptor activation : PTH is a low potency partial agonist at the rat PTH2_receptor .
24422147	0	PTH	48,51	PTHR1	19,24	PTH	PTHR1	5741	5745	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of PTHR1 regulates responses to PTH in vivo .
8663042	0	PTH	65,68	PTHRP	95,100	PTH	PTHRP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Structurally diverse N-terminal peptides of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHRP -RRB- inhibit the Na + / H + exchanger NHE3 isoform by binding to the PTH/PTHRP receptor type I and activating distinct signaling pathways .
10479735	0	PTH	47,50	PTHrP	73,78	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY studies|nmod|parathyroid_hormone studies|parataxis|point-mutated point-mutated|nsubj|PTH-related_protein PTH-related_protein|appos|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- point-mutated hybrids .
10674397	0	PTH	92,95	PTHrP	118,123	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- .
10784412	0	PTH	169,172	PTHrP	101,106	PTH	PTHrP	5741	5744	Gene	Gene	polymorphism|nmod|START_ENTITY polymorphism|nmod|intron intron|nmod|gene gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10784412	0	PTH	75,78	PTHrP	101,106	PTH	PTHrP	5741	5744	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10886551	0	PTH	41,44	PTHrP	0,5	PTH	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY enhances|dobj|response enhances|nsubj|END_ENTITY	PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid_glands .
11435617	0	PTH	33,36	PTHrP	144,149	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY Analysis|nmod|parathyroid_hormone Analysis|dep|receptor receptor|appos|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
11606467	0	PTH	0,3	PTHrP	79,84	PTH	PTHrP	19226(Tax:10090)	19227(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|calcium calcium|nmod|END_ENTITY	PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP .
1336486	1	PTH	138,141	PTHrP	168,173	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Radiolabeling of analogs derived from parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- .
17872377	0	PTH	44,47	PTHrP	74,79	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Altered selectivity of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- for distinct conformations of the PTH/PTHrP _ receptor .
18291038	0	PTH	85,88	PTHrP	49,54	PTH	PTHrP	5741	5744	Gene	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Substernal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level .
19567988	1	PTH	94,97	PTHrP	124,129	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Histological aspects on the action of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHrP -RRB- on bone and cartilage -RSB- .
21175413	0	PTH	29,32	PTHrP	59,64	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Role of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- in regulating mineral homeostasis during fetal development .
2178252	0	PTH	110,113	PTHrP	156,161	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Dissociation of cAMP accumulation and phosphate uptake in opossum kidney -LRB- OK -RRB- cells with parathyroid_hormone -LRB- PTH -RRB- and parathyroid_hormone related protein -LRB- PTHrP -RRB- .
23500550	0	PTH	45,48	PTHrP	75,80	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Current perspectives on parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- as bone anabolic therapies .
7599071	0	PTH	21,24	PTHrP	47,52	PTH	PTHrP	5741	5744	Gene	Gene	Parathyroid_hormone|appos|START_ENTITY Parathyroid_hormone|dep|expression expression|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
7857076	0	PTH	63,66	PTHrP	104,109	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY synthesis|nmod|parathyroid_hormone hormone|compound|synthesis hormone|appos|END_ENTITY	-LSB- Regulation of synthesis and secretion of parathyroid_hormone -LRB- PTH -RRB- and of tumor hypercalcemia hormone -LRB- PTHrP -RRB- -RSB- .
7857077	0	PTH	40,43	PTHrP	70,75	PTH	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	-LSB- Mode of action of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHrP -RRB- in target organs -RSB- .
8070351	0	PTH	21,24	PTHrP	47,52	PTH	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	Parathyroid_hormone|appos|START_ENTITY /|nsubj|Parathyroid_hormone /|dobj|receptor receptor|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor and its messenger ribonucleic_acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells : cell-specific regulation by angiotensin-II and PTHrP .
8756569	0	PTH	67,70	PTHrP	97,102	PTH	PTHrP	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Inverse agonism of amino-terminally truncated parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHrP -RRB- analogs revealed with constitutively active mutant PTH/PTHrP receptors .
9075739	0	PTH	95,98	PTHrP	121,126	PTH	PTHrP	5741	5744	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9345287	0	PTH	11,14	PTHrP	18,23	PTH	PTHrP	5741	5744	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of PTH on PTHrP gene expression in human osteoblasts : up-regulation with the kinetics of an immediate early gene .
9660083	0	PTH	75,78	PTHrP	101,106	PTH	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|dep|mRNA mRNA|appos|END_ENTITY	Pamidronate corrects the down-regulation of the renal parathyroid_hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptor mRNA in rats bearing Walker_tumors .
9737342	0	PTH	67,70	PTHrP	93,98	PTH	PTHrP	5741	5744	Gene	Gene	PTH-related_peptide|appos|START_ENTITY PTH-related_peptide|appos|END_ENTITY	Lymphoblastoid interferon-alpha downregulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor expression in human osteoblastic cells -LRB- Saos-2 -RRB- .
9751512	0	PTH	141,144	PTHrP	54,59	PTH	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	analogs|nmod|START_ENTITY activate|nmod|analogs activate|nsubj|receptors receptors|appos|END_ENTITY	Type-1 parathyroid hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH -LRB- 1-34 -RRB- .
9751512	0	PTH	28,31	PTHrP	54,59	PTH	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	hormone|appos|START_ENTITY Type-1|dep|hormone Type-1|parataxis|activate activate|nsubj|receptors receptors|appos|END_ENTITY	Type-1 parathyroid hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH -LRB- 1-34 -RRB- .
10951329	0	PTH	47,50	PTHrp	73,78	PTH	PTHrp	5741	5744	Gene	Gene	parathyroid_hormone|appos|START_ENTITY studies|nmod|parathyroid_hormone studies|parataxis|peptides peptides|nsubj|PTH-related_protein PTH-related_protein|appos|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrp -RRB- chimeric peptides .
25158085	0	PTH	51,54	Parathyroid_Hormone	30,49	PTH	Parathyroid Hormone	5741	5741	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	N-Terminal Phosphorylation of Parathyroid_Hormone -LRB- PTH -RRB- Abolishes Its Receptor Activity .
7649096	0	PTH	130,133	Parathyroid_hormone	0,19	PTH	Parathyroid hormone	399502(Tax:9823)	399502(Tax:9823)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related peptide receptor density modulates activation of phospholipase C and phosphate transport by PTH in LLC-PK1 cells .
9231754	0	PTH	21,24	Parathyroid_hormone	0,19	PTH	Parathyroid hormone	5741	24694(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Parathyroid_hormone -LRB- PTH 1-34 -RRB- regulation of rat osteocalcin gene transcription .
11517184	0	PTH	38,41	RANKL	102,107	PTH	RANKL	5741	8600	Gene	Gene	effects|nmod|START_ENTITY associated|nsubjpass|effects associated|nmod|stimulation stimulation|nmod|END_ENTITY	Catabolic effects of continuous human PTH -LRB- 1 -- 38 -RRB- in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation .
14505343	0	PTH	157,160	RANKL	80,85	PTH	RANKL	24694(Tax:10116)	117516(Tax:10116)	Gene	Gene	infused|nmod|START_ENTITY rats|acl|infused bone|nmod|rats mRNA|nmod|bone mRNA|compound|END_ENTITY	In vivo administration of 1,25-dihydroxyvitamin _ D3 suppresses the expression of RANKL mRNA in bone of thyroparathyroidectomized rats constantly infused with PTH .
14969393	0	PTH	0,3	RANKL	43,48	PTH	RANKL	19226(Tax:10090)	21943(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	PTH differentially regulates expression of RANKL and OPG .
20697756	0	PTH	0,3	RANKL	29,34	PTH	RANKL	5741	8600	Gene	Gene	START_ENTITY|dep|changes changes|nmod|END_ENTITY	PTH -LRB- 1-34 -RRB- - induced changes in RANKL and OPG expression by human PDL cells modify osteoclast biology in a co-culture model with RAW 264.7 cells .
15946907	0	PTH	26,29	SOST	0,4	PTH	SOST	24694(Tax:10116)	80722(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	SOST is a target gene for PTH in bone .
12210735	0	PTH	70,73	c-fos	8,13	PTH	c-fos	5741	2353	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP : localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer .
15476581	0	PTH	66,69	c-fos	149,154	PTH	c-fos	19226(Tax:10090)	14281(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY alleviates|dobj|action alleviates|nmod|inhibition inhibition|nmod|increase increase|nmod|mRNA mRNA|amod|END_ENTITY	Skeletal unloading alleviates the anabolic action of intermittent PTH -LRB- 1-34 -RRB- in mouse tibia in association with inhibition of PTH-induced increase in c-fos mRNA in bone marrow cells .
19419301	0	PTH	13,16	c-fos	136,141	PTH	c-fos	19226(Tax:10090)	14281(Tax:10090)	Gene	Gene	administration|compound|START_ENTITY stimulates|nsubj|administration stimulates|nmod|mice mice|amod|leading leading|nmod|formation formation|nmod|END_ENTITY	Intermittent PTH administration stimulates pre-osteoblastic proliferation without leading to enhanced bone formation in osteoclast-less c-fos -LRB- - / - -RRB- mice .
7962120	0	PTH	75,78	c-fos	30,35	PTH	c-fos	5741	2353	Gene	Gene	parathyroid_hormone|appos|START_ENTITY signaling|nmod|parathyroid_hormone signaling|nmod|induction induction|amod|END_ENTITY	Second messenger signaling of c-fos gene induction by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide in osteoblastic_osteosarcoma cells : its role in osteoblast proliferation and osteoclast-like cell formation .
9389528	0	PTH	76,79	c-fos	15,20	PTH	c-fos	19226(Tax:10090)	14281(Tax:10090)	Gene	Gene	parathyroid_hormone|appos|START_ENTITY regulated|nmod|parathyroid_hormone regulated|nsubjpass|END_ENTITY	Proto-oncogene c-fos is transcriptionally regulated by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein in a cyclic_adenosine_monophosphate-dependent manner in osteoblastic cells .
12107244	0	PTH	35,38	insulin	50,57	PTH	insulin	5741	3630	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Acute changes of bone turnover and PTH induced by insulin and glucose : euglycemic and hypoglycemic_hyperinsulinemic_clamp_studies .
10077343	0	PTH	69,72	interleukin-6	6,19	PTH	interleukin-6	5741	3569	Gene	Gene	relationship|nmod|START_ENTITY relationship|dep|END_ENTITY	Serum interleukin-6 in renal_osteodystrophy : relationship with serum PTH and bone remodeling markers .
25955226	0	PTH	29,32	osteocalcin	54,65	PTH	osteocalcin	5741	12097(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of treatment with PTH on undercarboxylated osteocalcin and energy metabolism in hypoparathyroidism .
9231754	0	PTH	21,24	osteocalcin	49,60	PTH	osteocalcin	5741	81613(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY END_ENTITY|nsubj|regulation	Parathyroid_hormone -LRB- PTH 1-34 -RRB- regulation of rat osteocalcin gene transcription .
18494002	0	PTH	25,28	osterix	44,51	PTH	osterix	5741	121340	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Teriparatide -LRB- 1-34 human PTH -RRB- regulation of osterix during fracture repair .
10784412	0	PTH	75,78	parathyroid_hormone	54,73	PTH	parathyroid hormone	5741	5741	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10965877	0	PTH	68,71	parathyroid_hormone	47,66	PTH	parathyroid hormone	405886(Tax:7955)	405886(Tax:7955)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Evaluating the ligand specificity of zebrafish parathyroid_hormone -LRB- PTH -RRB- receptors : comparison of PTH , PTH-related_protein , and tuberoinfundibular peptide of 39 residues .
11186329	0	PTH	69,72	parathyroid_hormone	48,67	PTH	parathyroid hormone	5741	5741	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Developmental and tissue-specific regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene expression .
1300345	0	PTH	36,39	parathyroid_hormone	15,34	PTH	parathyroid hormone	5741	5741	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of parathyroid_hormone -LRB- PTH -RRB- in genetic models of hypertension .
15762185	0	PTH	27,30	parathyroid_hormone	6,25	PTH	parathyroid hormone	5741	5741	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Serum parathyroid_hormone -LRB- PTH -RRB- levels in smokers and non-smokers .
16027955	0	PTH	44,47	parathyroid_hormone	23,42	PTH	parathyroid hormone	5741	5741	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Economic evaluation of parathyroid_hormone -LRB- PTH -RRB- in the treatment of osteoporosis in postmenopausal women .
1660713	0	PTH	49,52	parathyroid_hormone	28,47	PTH	parathyroid hormone	24694(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Specific down-regulation of parathyroid_hormone -LRB- PTH -RRB- receptors and responses to PTH by tumour_necrosis factor alpha and retinoic_acid in UMR 106-06 osteoblast-like osteosarcoma cells .
16944755	0	PTH	32,35	parathyroid_hormone	11,30	PTH	parathyroid hormone	5741	5741	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of parathyroid_hormone -LRB- PTH 1-34 -RRB- on hemopoiesis in long-term cultures of human bone marrow -RSB- .
19958930	0	PTH	67,70	parathyroid_hormone	46,65	PTH	parathyroid hormone	5741	5741	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Serum aldosterone is correlated positively to parathyroid_hormone -LRB- PTH -RRB- levels in patients with primary_hyperparathyroidism .
20451678	0	PTH	58,61	parathyroid_hormone	37,56	PTH	parathyroid hormone	5741	5741	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Hip fracture type : important role of parathyroid_hormone -LRB- PTH -RRB- response to hypovitaminosis D. OBJECTIVE : To investigate whether clinical and laboratory characteristics , including serum 25-hydroxyvitamin_D -LRB- 25 -LRB- OH -RRB- _ D -RRB- , PTH and parameters of mineral and bone metabolism , differ by hip_fracture -LRB- HF -RRB- type .
2155920	0	PTH	49,52	parathyroid_hormone	28,47	PTH	parathyroid hormone	396436(Tax:9031)	396436(Tax:9031)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Potent mitogenic effects of parathyroid_hormone -LRB- PTH -RRB- on embryonic chick and rabbit chondrocytes .
22722080	0	PTH	61,64	parathyroid_hormone	35,54	PTH	parathyroid hormone	5741	5741	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel homozygous mutation in the parathyroid_hormone gene -LRB- PTH -RRB- in a girl with isolated_hypoparathyroidism .
23240707	0	PTH	52,55	parathyroid_hormone	31,50	PTH	parathyroid hormone	5741	5741	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Digoxin-associated decrease in parathyroid_hormone -LRB- PTH -RRB- concentrations in patients with atrial_fibrillation .
23483040	0	PTH	80,83	parathyroid_hormone	59,78	PTH	parathyroid hormone	100351309(Tax:9986)	100351309(Tax:9986)	Gene	Gene	level|appos|START_ENTITY level|compound|END_ENTITY	Ultrasound exposure during pregnancy affects rabbit foetal parathyroid_hormone -LRB- PTH -RRB- level .
23533279	0	PTH	38,41	parathyroid_hormone	17,36	PTH	parathyroid hormone	19226(Tax:10090)	19226(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of parathyroid_hormone -LRB- PTH -RRB- receptor-1 phosphorylation in regulating acute responses to PTH .
3002757	0	PTH	40,43	parathyroid_hormone	19,38	PTH	parathyroid hormone	280903(Tax:9913)	280903(Tax:9913)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Down-regulation of parathyroid_hormone -LRB- PTH -RRB- receptors in cultured bone cells is associated with agonist-specific intracellular processing of PTH-receptor complexes .
6353628	0	PTH	32,35	parathyroid_hormone	6,25	PTH	parathyroid hormone	5741	5741	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human parathyroid_hormone gene -LRB- PTH -RRB- is on short arm of chromosome 11 .
8182566	0	PTH	31,34	parathyroid_hormone	10,29	PTH	parathyroid hormone	24694(Tax:10116)	24694(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of parathyroid_hormone -LRB- PTH -RRB- on replantation of amputated legs in a rat model .
8544835	0	PTH	57,60	parathyroid_hormone	36,55	PTH	parathyroid hormone	24694(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Homolog-scanning mutagenesis of the parathyroid_hormone -LRB- PTH -RRB- receptor reveals PTH - -LRB- 1-34 -RRB- binding determinants in the third extracellular loop .
9075739	0	PTH	95,98	parathyroid_hormone	74,93	PTH	parathyroid hormone	5741	5741	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9645678	0	PTH	62,65	parathyroid_hormone	41,60	PTH	parathyroid hormone	19226(Tax:10090)	19226(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The effect of cell-matrix interaction on parathyroid_hormone -LRB- PTH -RRB- receptor binding and PTH responsiveness in proximal_renal_tubular_cells_and_osteoblast-like_cells .
9737342	0	PTH	67,70	parathyroid_hormone	46,65	PTH	parathyroid hormone	5741	5741	Gene	Gene	PTH-related_peptide|appos|START_ENTITY END_ENTITY|dobj|PTH-related_peptide	Lymphoblastoid interferon-alpha downregulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor expression in human osteoblastic cells -LRB- Saos-2 -RRB- .
8732687	0	PTH-related_peptide	58,77	G_alpha_q	0,9	PTH-related peptide	G alpha q	5744	2776	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	G_alpha_q family members couple parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide and calcitonin receptors to phospholipase C in COS-7 cells .
10784412	0	PTH-related_peptide	80,99	PTH	75,78	PTH-related peptide	PTH	5744	5741	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
9075739	0	PTH-related_peptide	100,119	PTH	95,98	PTH-related peptide	PTH	5744	5741	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
10784412	0	PTH-related_peptide	80,99	PTHrP	101,106	PTH-related peptide	PTHrP	5744	5744	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
9075739	0	PTH-related_peptide	100,119	PTHrP	121,126	PTH-related peptide	PTHrP	5744	5744	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
10487664	0	PTH-related_peptide	34,53	parathyroid_hormone	8,27	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	mutation|amod|START_ENTITY novel|dep|mutation novel|dep|END_ENTITY	A novel parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor mutation in Jansen 's _ metaphyseal_chondrodysplasia .
10784412	0	PTH-related_peptide	80,99	parathyroid_hormone	54,73	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10875241	0	PTH-related_peptide	99,118	parathyroid_hormone	73,92	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	gene|amod|START_ENTITY Dissection|parataxis|gene Dissection|dep|promoters promoters|nmod|END_ENTITY	Dissection of differentially regulated -LRB- G+C -RRB- - rich promoters of the human parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene .
11014383	0	PTH-related_peptide	46,65	parathyroid_hormone	20,39	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	polymorphism|amod|START_ENTITY Association|dep|polymorphism Association|nmod|END_ENTITY	Association between parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene polymorphism and the extent of bone mass reduction in primary_hyperparathyroidism .
11159842	0	PTH-related_peptide	69,88	parathyroid_hormone	43,62	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Tuberoinfundibular peptide 39 binds to the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor , but functions as an antagonist .
11181543	0	PTH-related_peptide	48,67	parathyroid_hormone	22,41	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	regulation|amod|START_ENTITY immortalized|nsubj|regulation Signal-selectivity|parataxis|immortalized Signal-selectivity|nmod|END_ENTITY	Signal-selectivity of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor-mediated regulation of differentiation in conditionally immortalized growth-plate chondrocytes .
11186329	0	PTH-related_peptide	74,93	parathyroid_hormone	48,67	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	expression|amod|START_ENTITY /|dobj|expression /|nsubj|regulation regulation|nmod|END_ENTITY	Developmental and tissue-specific regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene expression .
7721741	0	PTH-related_peptide	80,99	parathyroid_hormone	54,73	PTH-related peptide	parathyroid hormone	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY enhances|nsubj|receptor Truncation|parataxis|enhances Truncation|nmod|END_ENTITY	Truncation of the carboxyl-terminal region of the rat parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C .
7745008	0	PTH-related_peptide	119,138	parathyroid_hormone	93,112	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	Pseudohypoparathyroidism_type_Ib is not caused by mutations in the coding exons of the human parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene .
8137752	0	PTH-related_peptide	84,103	parathyroid_hormone	58,77	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	acid|amod|START_ENTITY Role|dep|acid Role|nmod|down-regulation down-regulation|nmod|END_ENTITY	Role of protein kinase-A in homologous down-regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells .
8275958	0	PTH-related_peptide	40,59	parathyroid_hormone	14,33	PTH-related peptide	parathyroid hormone	286767(Tax:9913)	280903(Tax:9913)	Gene	Gene	acid|amod|START_ENTITY Regulation|dep|acid Regulation|nmod|END_ENTITY	Regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2 .8 and OK cells .
8299582	0	PTH-related_peptide	73,92	parathyroid_hormone	47,66	PTH-related peptide	parathyroid hormone	5744	24694(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY determines|nsubj|receptor region|dep|determines region|nmod|END_ENTITY	The extracellular amino-terminal region of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH - -LRB- 1-34 -RRB- .
8386606	0	PTH-related_peptide	51,70	parathyroid_hormone	25,44	PTH-related peptide	parathyroid hormone	24695(Tax:10116)	399502(Tax:9823)	Gene	Gene	receptors|amod|START_ENTITY activate|nsubj|receptors Cloned|parataxis|activate Cloned|acl|expressed expressed|dobj|END_ENTITY	Cloned , stably expressed parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells .
8732687	0	PTH-related_peptide	58,77	parathyroid_hormone	32,51	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|G_alpha_q G_alpha_q|dobj|END_ENTITY	G_alpha_q family members couple parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide and calcitonin receptors to phospholipase C in COS-7 cells .
8969199	0	PTH-related_peptide	87,106	parathyroid_hormone	61,80	PTH-related peptide	parathyroid hormone	100462910	100462909	Gene	Gene	receptor|amod|START_ENTITY critical|nsubj|receptor signal|parataxis|critical signal|nsubj|region region|nmod|loop loop|nmod|END_ENTITY	The N-terminal region of the third intracellular loop of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor is critical for coupling to cAMP and inositol_phosphate / Ca2 + signal transduction pathways .
8977437	0	PTH-related_peptide	58,77	parathyroid_hormone	32,51	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	gene|amod|START_ENTITY expression|dep|gene expression|nmod|END_ENTITY	Cell-specific expression of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene in kidney from kidney-specific and ubiquitous promoters .
9075739	0	PTH-related_peptide	100,119	parathyroid_hormone	74,93	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9727064	0	PTH-related_peptide	62,81	parathyroid_hormone	36,55	PTH-related peptide	parathyroid hormone	5744	5741	Gene	Gene	expression|amod|START_ENTITY upregulation|dep|expression upregulation|nmod|END_ENTITY	Developmental upregulation of human parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene expression from conserved and human-specific promoters .
20501677	0	PTH-related_peptide_receptor	60,88	PTH	131,134	PTH-related peptide receptor	PTH	19228(Tax:10090)	19226(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Phospholipase C signaling via the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide_receptor is essential for normal bone responses to PTH .
23235147	0	PTH-related_peptide_receptor	70,98	parathyroid_hormone	44,63	PTH-related peptide receptor	parathyroid hormone	19228(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	The IRE1a-XBP1 pathway positively regulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide_receptor expression and is involved in pth-induced osteoclastogenesis .
7599071	0	PTH-related_protein	26,45	PTHrP	47,52	PTH-related protein	PTHrP	5744	5744	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
8070351	0	PTH-related_protein	26,45	PTHrP	47,52	PTH-related protein	PTHrP	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor and its messenger ribonucleic_acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells : cell-specific regulation by angiotensin-II and PTHrP .
7599071	0	PTH-related_protein	26,45	Parathyroid_hormone	0,19	PTH-related protein	Parathyroid hormone	5744	5741	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
25505558	0	PTH1	186,190	parathyroid_hormone	166,185	PTH1	parathyroid hormone	5741	5741	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Green fluorescent protein fused to peptide agonists of two dissimilar G protein-coupled receptors : novel ligands of the bradykinin B2 -LRB- rhodopsin family -RRB- receptor and parathyroid_hormone PTH1 -LRB- secretin family -RRB- receptor .
25529820	0	PTH1R	49,54	Parathyroid_Hormone_Type_1_Receptor	12,47	PTH1R	Parathyroid Hormone Type 1 Receptor	5745	5745	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the Parathyroid_Hormone_Type_1_Receptor -LRB- PTH1R -RRB- as a Mechanosensor in Osteocyte Survival .
10497171	0	PTH1R	95,100	parathyroid_hormone	29,48	PTH1R	parathyroid hormone	5745	405886(Tax:7955)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Zebrafish express the common parathyroid_hormone / parathyroid_hormone-related peptide receptor -LRB- PTH1R -RRB- and a novel receptor -LRB- PTH3R -RRB- that is preferentially activated by mammalian and fugufish parathyroid_hormone-related peptide .
26647715	0	PTH1R	94,99	parathyroid_hormone	7,26	PTH1R	parathyroid hormone	507783(Tax:9913)	280903(Tax:9913)	Gene	Gene	modulating|nmod|START_ENTITY enhances|advcl|modulating enhances|nsubj|END_ENTITY	Bovine parathyroid_hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R .
25462297	0	PTH2R	92,97	parathyroid_hormone_2_receptor	60,90	PTH2R	parathyroid hormone 2 receptor	5746	5746	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	PFOA and PFOS are associated with reduced expression of the parathyroid_hormone_2_receptor -LRB- PTH2R -RRB- gene in women .
10499494	0	PTH2_receptor	126,139	PTH	78,81	PTH2 receptor	PTH	81753(Tax:10116)	5741	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	Comparison of rat and human parathyroid_hormone_2 -LRB- PTH2 -RRB- receptor activation : PTH is a low potency partial agonist at the rat PTH2_receptor .
7797535	0	PTH2_receptor	104,117	parathyroid_hormone	79,98	PTH2 receptor	parathyroid hormone	5746	5741	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Identification and functional expression of a receptor selectively recognizing parathyroid_hormone , the PTH2_receptor .
2055117	0	PTHLH	61,66	parathyroid_hormone-like_peptide	22,54	PTHLH	parathyroid hormone-like peptide	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the rat parathyroid_hormone-like_peptide gene -LRB- PTHLH -RRB- to chromosome 4 : evidence for conserved synteny between human chromosome 12 , mouse chromosome 6 , and rat chromosome 4 .
24422147	0	PTHR1	19,24	PTH	48,51	PTHR1	PTH	5745	5741	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of PTHR1 regulates responses to PTH in vivo .
22338074	0	PTHR1	72,77	Parathyroid_hormone	0,19	PTHR1	Parathyroid hormone	19228(Tax:10090)	19226(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY formation|nmod|mice induces|dobj|formation induces|nsubj|END_ENTITY	Parathyroid_hormone induces bone formation in phosphorylation-deficient PTHR1 knockin mice .
20156969	0	PTHR1	42,47	parathyroid_hormone	48,67	PTHR1	parathyroid hormone	5745	5741	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Immunohistochemical identification of the PTHR1 parathyroid_hormone receptor in normal and neoplastic human tissues .
15879577	0	PTHR1	102,107	parathyroid_hormone-related_peptide_receptor_type_1	49,100	PTHR1	parathyroid hormone-related peptide receptor type 1	5745	5745	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Parathyroid_hormone-related_peptide -LRB- hPTHrP -RRB- and parathyroid_hormone-related_peptide_receptor_type_1 -LRB- PTHR1 -RRB- expression in human thymus .
8663042	0	PTHRP	95,100	PTH	65,68	PTHRP	PTH	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Structurally diverse N-terminal peptides of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHRP -RRB- inhibit the Na + / H + exchanger NHE3 isoform by binding to the PTH/PTHRP receptor type I and activating distinct signaling pathways .
19487464	0	PTHrP	29,34	ADAMTS-7	0,8	PTHrP	ADAMTS-7	5744	11173	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	ADAMTS-7 , a direct target of PTHrP , adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor .
18247361	0	PTHrP	20,25	BMP-2	0,5	PTHrP	BMP-2	19227(Tax:10090)	12156(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	BMP-2 regulation of PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells .
20401668	0	PTHrP	0,5	BMP-6	15,20	PTHrP	BMP-6	5744	654	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast_cancer cells .
12700162	0	PTHrP	36,41	Calcium-sensing_receptor	0,24	PTHrP	Calcium-sensing receptor	5744	846	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Calcium-sensing_receptor stimulates PTHrP release by pathways dependent on PKC , p38 MAPK , JNK , and ERK1/2 in H-500 cells .
23956041	0	PTHrP	11,16	MMP9	34,38	PTHrP	MMP9	5744	4318	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of PTHrP on expression of MMP9 and MMP13 in sika deer antler chondrocytes .
10479735	0	PTHrP	73,78	PTH	47,50	PTHrP	PTH	5744	5741	Gene	Gene	PTH-related_protein|appos|START_ENTITY point-mutated|nsubj|PTH-related_protein studies|parataxis|point-mutated studies|nmod|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- point-mutated hybrids .
10674397	0	PTHrP	118,123	PTH	92,95	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- .
10784412	0	PTHrP	101,106	PTH	169,172	PTHrP	PTH	5744	5741	Gene	Gene	gene|appos|START_ENTITY intron|nmod|gene polymorphism|nmod|intron polymorphism|nmod|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10784412	0	PTHrP	101,106	PTH	75,78	PTHrP	PTH	5744	5741	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10886551	0	PTHrP	0,5	PTH	41,44	PTHrP	PTH	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|response response|nmod|END_ENTITY	PTHrP enhances the secretory response of PTH to a hypocalcemic stimulus in rat parathyroid_glands .
11435617	0	PTHrP	144,149	PTH	33,36	PTHrP	PTH	5744	5741	Gene	Gene	receptor|appos|START_ENTITY Analysis|dep|receptor Analysis|nmod|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
11606467	0	PTHrP	79,84	PTH	0,3	PTHrP	PTH	19227(Tax:10090)	19226(Tax:10090)	Gene	Gene	calcium|nmod|START_ENTITY regulates|dobj|calcium regulates|nsubj|END_ENTITY	PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP .
1336486	1	PTHrP	168,173	PTH	138,141	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Radiolabeling of analogs derived from parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- .
17872377	0	PTHrP	74,79	PTH	44,47	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Altered selectivity of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- for distinct conformations of the PTH/PTHrP _ receptor .
18291038	0	PTHrP	49,54	PTH	85,88	PTHrP	PTH	5744	5741	Gene	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Substernal oxyphil parathyroid adenoma producing PTHrP with hypercalcemia and normal PTH level .
19567988	1	PTHrP	124,129	PTH	94,97	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Histological aspects on the action of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHrP -RRB- on bone and cartilage -RSB- .
21175413	0	PTHrP	59,64	PTH	29,32	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Role of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- in regulating mineral homeostasis during fetal development .
2178252	0	PTHrP	156,161	PTH	110,113	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Dissociation of cAMP accumulation and phosphate uptake in opossum kidney -LRB- OK -RRB- cells with parathyroid_hormone -LRB- PTH -RRB- and parathyroid_hormone related protein -LRB- PTHrP -RRB- .
23500550	0	PTHrP	75,80	PTH	45,48	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Current perspectives on parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein -LRB- PTHrP -RRB- as bone anabolic therapies .
7599071	0	PTHrP	47,52	PTH	21,24	PTHrP	PTH	5744	5741	Gene	Gene	expression|appos|START_ENTITY Parathyroid_hormone|dep|expression Parathyroid_hormone|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
7857076	0	PTHrP	104,109	PTH	63,66	PTHrP	PTH	5744	5741	Gene	Gene	hormone|appos|START_ENTITY hormone|compound|synthesis synthesis|nmod|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	-LSB- Regulation of synthesis and secretion of parathyroid_hormone -LRB- PTH -RRB- and of tumor hypercalcemia hormone -LRB- PTHrP -RRB- -RSB- .
7857077	0	PTHrP	70,75	PTH	40,43	PTHrP	PTH	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	-LSB- Mode of action of parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHrP -RRB- in target organs -RSB- .
8070351	0	PTHrP	47,52	PTH	21,24	PTHrP	PTH	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY /|dobj|receptor /|nsubj|Parathyroid_hormone Parathyroid_hormone|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor and its messenger ribonucleic_acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells : cell-specific regulation by angiotensin-II and PTHrP .
8756569	0	PTHrP	97,102	PTH	67,70	PTHrP	PTH	5744	5741	Gene	Gene	parathyroid_hormone|appos|START_ENTITY parathyroid_hormone|appos|END_ENTITY	Inverse agonism of amino-terminally truncated parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide -LRB- PTHrP -RRB- analogs revealed with constitutively active mutant PTH/PTHrP receptors .
9075739	0	PTHrP	121,126	PTH	95,98	PTHrP	PTH	5744	5741	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9345287	0	PTHrP	18,23	PTH	11,14	PTHrP	PTH	5744	5741	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effects of PTH on PTHrP gene expression in human osteoblasts : up-regulation with the kinetics of an immediate early gene .
9660083	0	PTHrP	101,106	PTH	75,78	PTHrP	PTH	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY parathyroid_hormone|dep|mRNA parathyroid_hormone|appos|END_ENTITY	Pamidronate corrects the down-regulation of the renal parathyroid_hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptor mRNA in rats bearing Walker_tumors .
9737342	0	PTHrP	93,98	PTH	67,70	PTHrP	PTH	5744	5741	Gene	Gene	PTH-related_peptide|appos|START_ENTITY PTH-related_peptide|appos|END_ENTITY	Lymphoblastoid interferon-alpha downregulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor expression in human osteoblastic cells -LRB- Saos-2 -RRB- .
9751512	0	PTHrP	54,59	PTH	141,144	PTHrP	PTH	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY activate|nsubj|receptors activate|nmod|analogs analogs|nmod|END_ENTITY	Type-1 parathyroid hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH -LRB- 1-34 -RRB- .
9751512	0	PTHrP	54,59	PTH	28,31	PTHrP	PTH	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY activate|nsubj|receptors Type-1|parataxis|activate Type-1|dep|hormone hormone|appos|END_ENTITY	Type-1 parathyroid hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH -LRB- 1-34 -RRB- .
10784412	0	PTHrP	101,106	PTH-related_peptide	80,99	PTHrP	PTH-related peptide	5744	5744	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
9075739	0	PTHrP	121,126	PTH-related_peptide	100,119	PTHrP	PTH-related peptide	5744	5744	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
7599071	0	PTHrP	47,52	PTH-related_protein	26,45	PTHrP	PTH-related protein	5744	5744	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
8070351	0	PTHrP	47,52	PTH-related_protein	26,45	PTHrP	PTH-related protein	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor and its messenger ribonucleic_acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells : cell-specific regulation by angiotensin-II and PTHrP .
19616583	0	PTHrP	34,39	PTHrP	8,13	PTHrP	PTHrP	5744	5744	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival .
19616583	0	PTHrP	8,13	PTHrP	34,39	PTHrP	PTHrP	5744	5744	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell growth and survival .
19078166	0	PTHrP	45,50	Parathyroid_Hormone_Related_Peptide	8,43	PTHrP	Parathyroid Hormone Related Peptide	5744	5744	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Parathyroid_Hormone_Related_Peptide -LRB- PTHrP -RRB- in Hypercalcemia_of_Malignancy and the Development of Osteolytic Metastases .
7599071	0	PTHrP	47,52	Parathyroid_hormone	0,19	PTHrP	Parathyroid hormone	5744	5741	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dep|expression	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
8070351	0	PTHrP	47,52	Parathyroid_hormone	0,19	PTHrP	Parathyroid hormone	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY /|dobj|receptor /|nsubj|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor and its messenger ribonucleic_acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells : cell-specific regulation by angiotensin-II and PTHrP .
11595209	0	PTHrP	37,42	Parathyroid_hormone-related_protein	0,35	PTHrP	Parathyroid hormone-related protein	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- induction in reactive astrocytes following brain_injury : a possible mediator of CNS inflammation .
15800941	0	PTHrP	120,125	Parathyroid_hormone-related_protein	0,35	PTHrP	Parathyroid hormone-related protein	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- as a causative factor of cancer-associated wasting : possible involvement of PTHrP in the repression of locomotor activity in rats bearing human tumor xenografts .
8277370	0	PTHrP	37,42	Parathyroid_hormone-related_protein	0,35	PTHrP	Parathyroid hormone-related protein	5744	5744	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- gene expression in solid tumours associated with normocalcaemia and hypercalcaemia .
22102368	0	PTHrP	0,5	RANKL	16,21	PTHrP	RANKL	5744	8600	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	PTHrP increases RANKL expression by stromal cells from giant_cell_tumor_of_bone .
20637541	0	PTHrP	0,5	Rac1	115,119	PTHrP	Rac1	5744	5879	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	PTHrP promotes colon_cancer cell migration and invasion in an integrin a6b4-dependent manner through activation of Rac1 .
18030616	0	PTHrP	10,15	Rip1	26,30	PTHrP	Rip1	5744	8737	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Midregion PTHrP regulates Rip1 and caspase expression in MDA-MB231 breast_cancer cells .
16377269	0	PTHrP	39,44	calcium-sensing_receptor	4,28	PTHrP	calcium-sensing receptor	19227(Tax:10090)	12374(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The calcium-sensing_receptor regulates PTHrP production and calcium transport in the lactating mammary gland .
27039827	0	PTHrP	17,22	mTORC1	0,6	PTHrP	mTORC1	19227(Tax:10090)	382056(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	mTORC1 regulates PTHrP to coordinate chondrocyte growth , proliferation and differentiation .
11132926	0	PTHrP	14,19	p53	112,115	PTHrP	p53	5744	7157	Gene	Gene	expression|amod|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of PTHrP gene expression in squamous_carcinoma cell lines by mutant isoforms of the tumor suppressor p53 .
15124025	0	PTHrP	82,87	p57	38,41	PTHrP	p57	19227(Tax:10090)	12721(Tax:10090)	Gene	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	The cyclin-dependent kinase inhibitor p57 -LRB- Kip2 -RRB- mediates proliferative actions of PTHrP in chondrocytes .
10479735	0	PTHrP	73,78	parathyroid_hormone	26,45	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	PTH-related_protein|appos|START_ENTITY point-mutated|nsubj|PTH-related_protein studies|parataxis|point-mutated studies|nmod|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- point-mutated hybrids .
10784412	0	PTHrP	101,106	parathyroid_hormone	54,73	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
11435617	0	PTHrP	144,149	parathyroid_hormone	12,31	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	receptor|appos|START_ENTITY Analysis|dep|receptor Analysis|nmod|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
7857076	0	PTHrP	104,109	parathyroid_hormone	42,61	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	hormone|appos|START_ENTITY hormone|compound|synthesis synthesis|nmod|END_ENTITY	-LSB- Regulation of synthesis and secretion of parathyroid_hormone -LRB- PTH -RRB- and of tumor hypercalcemia hormone -LRB- PTHrP -RRB- -RSB- .
9075739	0	PTHrP	121,126	parathyroid_hormone	74,93	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9660083	0	PTHrP	101,106	parathyroid_hormone	54,73	PTHrP	parathyroid hormone	24695(Tax:10116)	24694(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY END_ENTITY|dep|mRNA	Pamidronate corrects the down-regulation of the renal parathyroid_hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptor mRNA in rats bearing Walker_tumors .
9737342	0	PTHrP	93,98	parathyroid_hormone	46,65	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	PTH-related_peptide|appos|START_ENTITY END_ENTITY|dobj|PTH-related_peptide	Lymphoblastoid interferon-alpha downregulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor expression in human osteoblastic cells -LRB- Saos-2 -RRB- .
9747354	0	PTHrP	143,148	parathyroid_hormone	123,142	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	not|parataxis|START_ENTITY not|nmod|END_ENTITY	Human keratinocytes express transcripts for three isoforms of parathyroid_hormone-related protein -LRB- PTHrP -RRB- , but not for the parathyroid_hormone / PTHrP receptor : effects of 1,25 -LRB- OH -RRB- 2_vitamin_D3 .
9747354	0	PTHrP	99,104	parathyroid_hormone	123,142	PTHrP	parathyroid hormone	5744	5741	Gene	Gene	protein|appos|START_ENTITY isoforms|nmod|protein express|nmod|isoforms express|dep|not not|nmod|END_ENTITY	Human keratinocytes express transcripts for three isoforms of parathyroid_hormone-related protein -LRB- PTHrP -RRB- , but not for the parathyroid_hormone / PTHrP receptor : effects of 1,25 -LRB- OH -RRB- 2_vitamin_D3 .
1280327	0	PTHrP	51,56	parathyroid_hormone-related_peptide	14,49	PTHrP	parathyroid hormone-related peptide	5744	5744	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of parathyroid_hormone-related_peptide -LRB- PTHrP -RRB- gene transcription : cell - and tissue-specific promoter utilization mediated by multiple positive and negative cis-acting DNA elements .
9274527	0	PTHrP	51,56	parathyroid_hormone-related_peptide	14,49	PTHrP	parathyroid hormone-related peptide	5744	5744	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of parathyroid_hormone-related_peptide -LRB- PTHrP -RRB- in gastric_tumours .
11813867	0	PTHrP	51,56	parathyroid_hormone-related_protein	14,49	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in parathyroid tissue under normal and pathological conditions .
11940209	0	PTHrP	51,56	parathyroid_hormone-related_protein	14,49	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in multiple_myeloma .
12243970	0	PTHrP	54,59	parathyroid_hormone-related_protein	17,52	PTHrP	parathyroid hormone-related protein	19227(Tax:10090)	19227(Tax:10090)	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	The influence of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- on tooth-germ development and osteoclastogenesis in alveolar bone of PTHrP-knock out and wild-type mice in vitro .
14518259	0	PTHrP	156,161	parathyroid_hormone-related_protein	119,154	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Detection of disseminated carcinoma cells in bone marrow and peripheral blood in primary breast_cancer with RT/PCR of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- -RSB- .
1544706	0	PTHrP	71,76	parathyroid_hormone-related_protein	34,69	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Immunohistochemical evaluation of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in the uterine cervix .
16462110	0	PTHrP	51,56	parathyroid_hormone-related_protein	14,49	PTHrP	parathyroid hormone-related protein	286767(Tax:9913)	286767(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- mRNA in mammary gland of periparturient cows .
16704084	0	PTHrP	58,63	parathyroid_hormone-related_protein	21,56	PTHrP	parathyroid hormone-related protein	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Seasonal rhythms of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- expression in growing rats after functional mandibular protrusion -RSB- .
19519497	0	PTHrP	49,54	parathyroid_hormone-related_protein	12,47	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in the pathophysiology of diabetes_mellitus .
25867375	0	PTHrP	111,116	parathyroid_hormone-related_protein	69,104	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification , molecular characterization , and tissue expression of parathyroid_hormone-related_protein gene -LRB- PTHrP -RRB- from water_buffalo -LRB- Bubalus_bubalis -RRB- .
7799315	0	PTHrP	47,52	parathyroid_hormone-related_protein	10,45	PTHrP	parathyroid hormone-related protein	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- on the contractility of the myometrium and localization of PTHrP in the uterus of pregnant rats .
7824450	0	PTHrP	73,78	parathyroid_hormone-related_protein	36,71	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in human term placenta and membranes .
9162079	0	PTHrP	70,75	parathyroid_hormone-related_protein	33,68	PTHrP	parathyroid hormone-related protein	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Activity-dependent expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in rat cerebellar granule neurons .
9397964	0	PTHrP	65,70	parathyroid_hormone-related_protein	28,63	PTHrP	parathyroid hormone-related protein	5744	5744	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dexamethasone regulation of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- expression in a squamous cancer cell line .
15249318	0	PTHrP	59,64	parathyroid_hormone_related_protein	22,57	PTHrP	parathyroid hormone related protein	100009357(Tax:9986)	100009357(Tax:9986)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Sequential changes of parathyroid_hormone_related_protein -LRB- PTHrP -RRB- in articular cartilage during progression of inflammatory and degenerative_arthritis .
2051695	0	PTHrP	67,72	parathyroid_hormone_related_protein	30,65	PTHrP	parathyroid hormone related protein	5744	5744	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	-LSB- Immunohistochemical study of parathyroid_hormone_related_protein -LRB- PTHrP -RRB- in renal_cell_carcinoma -RSB- .
11435617	0	PTHrP	144,149	pth	118,121	PTHrP	pth	5744	5741	Gene	Gene	receptor|appos|START_ENTITY Analysis|dep|receptor Analysis|dep|differentiates differentiates|dobj|role role|nmod|domains domains|nmod|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
11435617	0	PTHrP	144,149	pth-related_peptide	123,142	PTHrP	pth-related peptide	5744	5744	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
10951329	0	PTHrp	73,78	PTH	47,50	PTHrp	PTH	5744	5741	Gene	Gene	PTH-related_protein|appos|START_ENTITY peptides|nsubj|PTH-related_protein studies|parataxis|peptides studies|nmod|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrp -RRB- chimeric peptides .
10951329	0	PTHrp	73,78	parathyroid_hormone	26,45	PTHrp	parathyroid hormone	5744	5741	Gene	Gene	PTH-related_protein|appos|START_ENTITY peptides|nsubj|PTH-related_protein studies|parataxis|peptides studies|nmod|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrp -RRB- chimeric peptides .
19583951	0	PTIP	30,34	PPARgamma	51,60	PTIP	PPARgamma	55982(Tax:10090)	19016(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis .
10908331	0	PTIP	0,4	Pax2	60,64	PTIP	Pax2	22976	5076	Gene	Gene	BRCT|advmod|START_ENTITY BRCT|nmod|END_ENTITY	PTIP , a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin .
19124460	0	PTIP	65,69	Pax2	16,20	PTIP	Pax2	22976	5076	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Accumulation of Pax2 transactivation domain interaction protein -LRB- PTIP -RRB- at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage .
25631048	0	PTIP	99,103	Pax2	140,144	PTIP	Pax2	22976	5076	Gene	Gene	Pax_Transactivation_Domain_Interacting_Protein|appos|START_ENTITY Displaces|dobj|Pax_Transactivation_Domain_Interacting_Protein Displaces|xcomp|Switch Switch|dobj|END_ENTITY	The Groucho-associated Phosphatase PPM1B Displaces Pax_Transactivation_Domain_Interacting_Protein -LRB- PTIP -RRB- to Switch the Transcription Factor Pax2 from a Transcriptional Activator to a Repressor .
12707376	0	PTK	38,41	protein_tyrosine-kinase	13,36	PTK	protein tyrosine-kinase	2264	2264	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of protein_tyrosine-kinase -LRB- PTK -RRB- gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresis .
23352614	0	PTK6	0,4	c-Cbl	29,34	PTK6	c-Cbl	5753	867	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation .
18781181	0	PTK6	47,51	protein_tyrosine_kinase_6	20,45	PTK6	protein tyrosine kinase 6	5753	5753	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of protein_tyrosine_kinase_6 -LRB- PTK6 -RRB- for long-term survival of breast_cancer patients .
23525678	0	PTK6	41,45	protein_tyrosine_kinase_6	14,39	PTK6	protein tyrosine kinase 6	5753	5753	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of protein_tyrosine_kinase_6 -LRB- PTK6 -RRB- in nonsmall_cell_lung_cancer and their clinical and prognostic significance .
25997931	0	PTK7	0,4	Angiopoietin-1	96,110	PTK7	Angiopoietin-1	71461(Tax:10090)	11600(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|nmod|END_ENTITY	PTK7 + Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1 .
25204555	0	PTK7	0,4	Id1	15,18	PTK7	Id1	71461(Tax:10090)	15901(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	PTK7 regulates Id1 expression in CD44-high glioma cells .
25986862	0	PTK7	19,23	KDR	27,30	PTK7	KDR	5754	3791	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	Biphasic effect of PTK7 on KDR activity in endothelial cells and angiogenesis .
20946874	0	PTK7	24,28	PlexinA1	0,8	PTK7	PlexinA1	398862(Tax:8355)	397805(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PlexinA1 interacts with PTK7 and is required for neural crest migration .
19004858	0	PTK7	0,4	dsh	14,17	PTK7	dsh	398862(Tax:8355)	399301(Tax:8355)	Gene	Gene	recruits|compound|START_ENTITY END_ENTITY|nsubj|recruits	PTK7 recruits dsh to regulate neural crest migration .
18807071	0	PTL-1	48,53	microtubule-associated_protein	17,47	PTL-1	microtubule-associated protein	175230(Tax:6239)	175230(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY functions|amod|END_ENTITY	The invertebrate microtubule-associated_protein PTL-1 functions in mechanosensation and development in Caenorhabditis_elegans .
10962555	1	PTN	65,68	pleiotrophin	104,116	PTN	pleiotrophin	5764	5764	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	PTN on the expression of growth factor pleiotrophin : a critical role of a retroviral Sp1-binding site .
11510908	0	PTN	60,63	pleiotrophin	46,58	PTN	pleiotrophin	19242(Tax:10090)	19242(Tax:10090)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of the angiogenetic factor pleiotrophin -LRB- PTN -RRB- in the growth plate of mice .
15181449	0	PTOP	0,4	POT1	20,24	PTOP	POT1	65057	25913	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PTOP interacts with POT1 and regulates its localization to telomeres .
21110951	0	PTOV1	0,5	MED25	18,23	PTOV1	MED25	53635	81857	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	PTOV1 antagonizes MED25 in RAR transcriptional activation .
21678139	0	PTOV1	0,5	UCH-L1	25,31	PTOV1	UCH-L1	84113(Tax:10090)	22223(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development .
23321499	0	PTOV1	22,27	Zyxin	0,5	PTOV1	Zyxin	53635	7791	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Zyxin cooperates with PTOV1 to confer retinoic_acid resistance by repressing RAR activity .
21926414	0	PTP	104,107	IL1RAPL1	45,53	PTP	IL1RAPL1	10076	11141	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The X-linked intellectual_disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTP and RhoGAP2 .
26896769	0	PTP	21,24	NME2	0,4	PTP	NME2	10076	4831	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	NME2 associates with PTP to transduce signals from chondroitin sulfate proteoglycans .
22583656	0	PTP	30,33	Protein_tyrosine_phosphatase	0,28	PTP	Protein tyrosine phosphatase	26191	26191	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Protein_tyrosine_phosphatase -LRB- PTP -RRB- inhibition enhances chromosomal stability after genotoxic stress : decreased chromosomal_instability -LRB- CIN -RRB- at the expense of enhanced genomic_instability -LRB- GIN -RRB- ?
8626139	0	PTP-1B	127,133	PTP-alpha	135,144	PTP-1B	PTP-alpha	5770	5786	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transfection of human ovarian_cancer cells with the HER-2 / neu receptor_tyrosine_kinase induces a selective increase in PTP-H1 , PTP-1B , PTP-alpha expression .
12810595	0	PTP-ER	99,105	DMKP3	48,53	PTP-ER	DMKP3	37461(Tax:7227)	40081(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER .
22763125	0	PTP-MEG2	21,29	vascular_endothelial_growth_factor	51,85	PTP-MEG2	vascular endothelial growth factor	5780	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptor receptor|compound|END_ENTITY	Tyrosine phosphatase PTP-MEG2 negatively regulates vascular_endothelial_growth_factor receptor signaling and function in endothelial cells .
8887669	0	PTP-PEST	90,98	p130	18,22	PTP-PEST	p130	5782	9221	Gene	Gene	substrate|nmod|START_ENTITY Identification|nmod|substrate Identification|nmod|END_ENTITY	Identification of p130 -LRB- cas -RRB- as a substrate for the cytosolic protein_tyrosine_phosphatase PTP-PEST .
9285683	0	PTP-PEST	15,23	p130cas	47,54	PTP-PEST	p130cas	5782	9564	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Association of PTP-PEST with the SH3 domain of p130cas ; a novel mechanism of protein tyrosine phosphatase substrate recognition .
9287362	0	PTP-PEST	90,98	p50csk	35,41	PTP-PEST	p50csk	5782	1445	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells .
12042304	0	PTP-SL	37,43	ERK5	58,62	PTP-SL	ERK5	5801	5598	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Phosphotyrosine-specific phosphatase PTP-SL regulates the ERK5 signaling pathway .
8626139	0	PTP-alpha	135,144	PTP-1B	127,133	PTP-alpha	PTP-1B	5786	5770	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transfection of human ovarian_cancer cells with the HER-2 / neu receptor_tyrosine_kinase induces a selective increase in PTP-H1 , PTP-1B , PTP-alpha expression .
25586181	0	PTP1B	81,86	Calnexin	35,43	PTP1B	Calnexin	5770	821	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	UBC9-dependent Association between Calnexin and Protein_Tyrosine_Phosphatase_1B -LRB- PTP1B -RRB- at the Endoplasmic Reticulum .
26328540	0	PTP1B	36,41	GSK-3b	87,93	PTP1B	GSK-3b	19246(Tax:10090)	56637(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Combination of PKC Activation and PTP1B Inhibition Effectively Suppresses Ab-Induced GSK-3b Activation and Tau Phosphorylation .
18571728	0	PTP1B	12,17	MyD88	39,44	PTP1B	MyD88	5770	4615	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Phosphatase PTP1B negatively regulates MyD88 - and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages .
24239742	0	PTP1B	25,30	Nox4	0,4	PTP1B	Nox4	5770	50507	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Nox4 redox regulation of PTP1B contributes to the proliferation and migration_of_glioblastoma cells by modulating tyrosine phosphorylation of coronin-1C .
25364621	0	PTP1B	172,177	Protein-Tyrosine_Phosphatase1B	140,170	PTP1B	Protein-Tyrosine Phosphatase1B	5770	5770	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	4 - -LRB- -LRB- 1E -RRB- -2 - -LRB- 5 - -LRB- 4-hydroxy-3-methoxystyryl - -RRB- -1 - phenyl-1H-pyrazoyl-3-yl -RRB- _ vinyl -RRB- -2 - methoxy-phenol -RRB- -LRB- CNB-001 -RRB- Does Not Regulate Human Recombinant Protein-Tyrosine_Phosphatase1B -LRB- PTP1B -RRB- Activity in vitro .
25643610	0	PTP1B	59,64	Protein_Tyrosine_Phosphatase_1B	26,57	PTP1B	Protein Tyrosine Phosphatase 1B	5770	5770	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Small Molecules as Potent Protein_Tyrosine_Phosphatase_1B -LRB- PTP1B -RRB- Inhibitors Documented in Patents from 2009 to 2013 .
18716132	0	PTP1B	0,5	STAT6	55,60	PTP1B	STAT6	5770	6778	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PTP1B is a negative regulator of interleukin_4-induced STAT6 signaling .
22166493	0	PTP1B	28,33	TNFa	0,4	PTP1B	TNFa	24697(Tax:10116)	24835(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	TNFa increases hypothalamic PTP1B activity via the NFkB pathway in rat hypothalamic organotypic cultures .
18387954	0	PTP1B	0,5	cortactin	16,25	PTP1B	cortactin	5770	2017	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446 .
21102485	0	PTP1B	74,79	protein-tyrosine_phosphatase-1B	41,72	PTP1B	protein-tyrosine phosphatase-1B	24697(Tax:10116)	24697(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Chronic ethanol consumption up-regulates protein-tyrosine_phosphatase-1B -LRB- PTP1B -RRB- expression in rat skeletal muscle .
12617932	0	PTP1B	82,87	protein_tyrosine_phosphatase_1B	49,80	PTP1B	protein tyrosine phosphatase 1B	5770	5770	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Modification of the N-terminus of peptidomimetic protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- inhibitors : identification of analogues with cellular activity .
16076179	0	PTP1B	74,79	protein_tyrosine_phosphatase_1B	41,72	PTP1B	protein tyrosine phosphatase 1B	5770	5770	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	A chemical model for redox regulation of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- activity .
21571537	0	PTP1B	87,92	protein_tyrosine_phosphatase_1B	54,85	PTP1B	protein tyrosine phosphatase 1B	5770	5770	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	New 5-deoxyflavonoids and their inhibitory effects on protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- activity .
22263876	0	PTP1B	67,72	protein_tyrosine_phosphatase_1B	34,65	PTP1B	protein tyrosine phosphatase 1B	5770	5770	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Specific inhibition of sensitized protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- with a biarsenical probe .
23022281	0	PTP1B	65,70	protein_tyrosine_phosphatase_1B	32,63	PTP1B	protein tyrosine phosphatase 1B	5770	5770	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	New prenylated isoflavonoids as protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- inhibitors from Erythrina addisoniae .
24625984	0	PTP1B	49,54	protein_tyrosine_phosphatase_1B	16,47	PTP1B	protein tyrosine phosphatase 1B	5770	5770	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Pivotal role of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- in the macrophage response to pro-inflammatory and anti-inflammatory challenge .
23901112	0	PTP1B	33,38	thioredoxin	46,57	PTP1B	thioredoxin	5770	7295	Gene	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-b receptor tyrosine kinase signaling .
11594781	0	PTP1D	36,41	Stat3	85,90	PTP1D	Stat3	5781	6774	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin .
8395005	0	PTP2	50,54	PTC1	105,109	PTP2	PTC1	854383(Tax:4932)	851558(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Mutations in a protein tyrosine phosphatase gene -LRB- PTP2 -RRB- and a protein serine/threonine phosphatase gene -LRB- PTC1 -RRB- cause a synthetic growth defect in Saccharomyces_cerevisiae .
7515062	0	PTP2C	78,83	insulin_receptor_substrate_1	21,49	PTP2C	insulin receptor substrate 1	5781	3667	Gene	Gene	Dephosphorylation|nmod|START_ENTITY Dephosphorylation|nmod|END_ENTITY	Dephosphorylation of insulin_receptor_substrate_1 by the tyrosine phosphatase PTP2C .
21555304	0	PTP4A3	41,47	PRL-3	34,39	PTP4A3	PRL-3	11156	11156	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical assessment of PRL-3 -LRB- PTP4A3 -RRB- expression in tumor buds , invasion front , central region of tumor and metastases of colorectal_cancer .
24403062	0	PTP4A3	34,40	vascular_endothelial_growth_factor	51,85	PTP4A3	vascular endothelial growth factor	19245(Tax:10090)	22339(Tax:10090)	Gene	Gene	promotes|dep|START_ENTITY promotes|dobj|END_ENTITY	Protein-tyrosine_phosphatase_4A3 -LRB- PTP4A3 -RRB- promotes vascular_endothelial_growth_factor signaling and enables endothelial cell motility .
24100351	0	PTPA	39,43	PP2A	20,24	PTPA	PP2A	5524	5524	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|basis basis|nmod|END_ENTITY	Structural basis of PP2A activation by PTPA , an ATP-dependent activation chaperone .
21119599	0	PTPH1	0,5	vitamin_D_receptor	22,40	PTPH1	vitamin D receptor	5774	7421	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	PTPH1 cooperates with vitamin_D_receptor to stimulate breast_cancer growth through their mutual stabilization .
18854601	0	PTPIP51	53,60	Protein_tyrosine_phosphatase_interacting_protein_51	0,51	PTPIP51	Protein tyrosine phosphatase interacting protein 51	55177	55177	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Protein_tyrosine_phosphatase_interacting_protein_51 -LRB- PTPIP51 -RRB- mRNA expression and localization and its in vitro interacting partner protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- in human placenta of the first , second , and third trimester .
22131369	0	PTPIP51	46,53	VAPB	0,4	PTPIP51	VAPB	55177	9217	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis .
15782144	0	PTPL1	0,5	EWS-FLI1	44,52	PTPL1	EWS-FLI1	5783	2130;2313	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing 's Sarcoma_tumorigenesis .
23018179	0	PTPL1	95,100	Valosin_containing_protein	0,26	PTPL1	Valosin containing protein	19249(Tax:10090)	269523(Tax:10090)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Valosin_containing_protein -LRB- VCP/p97 -RRB- is a novel substrate for the protein tyrosine phosphatase PTPL1 .
25311528	0	PTPN1	36,41	FGFR3	27,32	PTPN1	FGFR3	5770	2261	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of FGFR3 by PTPN1 and PTPN2 .
17634210	0	PTPN1	58,63	protein_tyrosine_phosphatase_1B	25,56	PTPN1	protein tyrosine phosphatase 1B	5770	5770	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms within the protein_tyrosine_phosphatase_1B -LRB- PTPN1 -RRB- gene promoter : functional characterization and association with type_2_diabetes and related metabolic traits .
17214991	0	PTPN11	27,33	SHP-2	0,5	PTPN11	SHP-2	5781	5781	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women .
21393858	0	PTPN11	6,12	SHP-2	0,5	PTPN11	SHP-2	19247(Tax:10090)	19247(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|appos|mediates	SHP-2 / PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans .
20308328	0	PTPN11	22,28	SHP2	30,34	PTPN11	SHP2	5781	5781	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Functional effects of PTPN11 -LRB- SHP2 -RRB- mutations causing LEOPARD_syndrome on epidermal growth factor-induced phosphoinositide_3-kinase / AKT/glycogen _ synthase_kinase_3beta signaling .
17227708	0	PTPN11	18,24	Shp2	12,16	PTPN11	Shp2	5781	5781	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of Shp2 -LRB- PTPN11 -RRB- in cancer .
19509418	0	PTPN11	43,49	Stat3	23,28	PTPN11	Stat3	5781	6774	Gene	Gene	mutants|compound|START_ENTITY END_ENTITY|nmod|mutants	Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan_syndrome and juvenile_myelomonocytic_leukemia .
25803229	0	PTPN14	107,113	MiR-21	0,6	PTPN14	MiR-21	5784	406991	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-21 promotes intrahepatic_cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN .
23613971	0	PTPN14	25,31	YAP	59,62	PTPN14	YAP	5784	10413	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity .
24608439	0	PTPN2	150,155	BACH2	0,5	PTPN2	BACH2	5771	60468	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	BACH2 , a candidate risk gene for type 1 diabetes , regulates apoptosis in pancreatic b-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2 .
21551237	0	PTPN2	0,5	JAK1	37,41	PTPN2	JAK1	5771	3716	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	PTPN2 negatively regulates oncogenic JAK1 in T-cell_acute_lymphoblastic_leukemia .
23759247	0	PTPN2	20,25	TC-PTP	12,18	PTPN2	TC-PTP	5771	5771	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of TC-PTP -LRB- PTPN2 -RRB- in modulating sensitivity to imatinib and interferon-a in CML cell line , KT-1 cells .
25289035	0	PTPN22	29,35	Protein_tyrosine_phosphatase	0,28	PTPN22	Protein tyrosine phosphatase	26191	26191	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Protein_tyrosine_phosphatase PTPN22 +1858 C/T polymorphism is associated with active vitiligo .
16893384	0	PTPN22	51,57	Protein_tyrosine_phosphatase_non-receptor_type_22	0,49	PTPN22	Protein tyrosine phosphatase non-receptor type 22	26191	26191	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Protein_tyrosine_phosphatase_non-receptor_type_22 -LRB- PTPN22 -RRB- gene R620W variant and sporadic_idiopathic_hypoparathyroidism in Asian Indians .
23261816	0	PTPN22	77,83	protein_tyrosine_phosphatase	48,76	PTPN22	protein tyrosine phosphatase	26191	26191	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The putative role of the C1858T polymorphism of protein_tyrosine_phosphatase PTPN22 gene in autoimmunity .
18578611	0	PTPN22	61,67	protein_tyrosine_phosphatase_nonreceptor_22	16,59	PTPN22	protein tyrosine phosphatase nonreceptor 22	26191	26191	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations of protein_tyrosine_phosphatase_nonreceptor_22 -LRB- PTPN22 -RRB- gene polymorphisms with susceptibility to Graves ' _ disease in a Japanese population .
11001933	0	PTPN6	77,82	hematopoietic_cell_phosphatase	45,75	PTPN6	hematopoietic cell phosphatase	5777	5777	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	RNA hyperediting and alternative splicing of hematopoietic_cell_phosphatase -LRB- PTPN6 -RRB- gene in acute_myeloid_leukemia .
20335174	0	PTPN9	29,34	ErbB2	56,61	PTPN9	ErbB2	5780	2064	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal_growth_factor_receptor signaling in breast_cancer cells .
12810785	0	PTPRC	16,21	CD45	23,27	PTPRC	CD45	5788	5788	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	The role of the PTPRC -LRB- CD45 -RRB- mutation in the development of multiple_sclerosis in the North West region of the United Kingdom .
18634151	0	PTPRC	77,82	CD45	84,88	PTPRC	CD45	5788	5788	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No association between systemic_sclerosis and C77G polymorphism in the human PTPRC -LRB- CD45 -RRB- gene .
21323873	0	PTPRC	127,132	CD45	134,138	PTPRC	CD45	5788	5788	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Outcome of children treated with haematopoietic-stem cell transplantations from donors expressing the rare C77G variant of the PTPRC -LRB- CD45 -RRB- gene .
22977525	0	PTPRD	21,26	CD44	87,91	PTPRD	CD44	5789	960	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Tyrosine phosphatase PTPRD suppresses colon_cancer cell migration in coordination with CD44 .
26079428	0	PTPRD	0,5	insulin_receptor	50,66	PTPRD	insulin receptor	5789	3643	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	PTPRD silencing by DNA hypermethylation decreases insulin_receptor signaling and leads to type_2_diabetes .
8833149	0	PTPRG	65,70	receptor_tyrosine_phosphatase_gamma	23,58	PTPRG	receptor tyrosine phosphatase gamma	5793	5793	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the human receptor_tyrosine_phosphatase_gamma gene -LRB- PTPRG -RRB- and relation to the familial_RCC_t -LRB- 3 ; 8 -RRB- chromosome translocation .
25532119	0	PTPRJ	24,29	COX-2	33,38	PTPRJ	COX-2	100347798(Tax:9986)	808233(Tax:9986)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Regulated Expression of PTPRJ by COX-2 / PGE2 Axis in Endothelial Cells .
25672645	0	PTPRJ	53,58	matrix_metalloproteinase-9	68,94	PTPRJ	matrix metalloproteinase-9	5795	4318	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Deficiency of the protein-tyrosine phosphatase DEP-1 / PTPRJ promotes matrix_metalloproteinase-9 expression in meningioma cells .
17720884	0	PTPRK	45,50	TGF-beta	23,31	PTPRK	TGF-beta	5796	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Down-regulation of the TGF-beta target gene , PTPRK , by the Epstein-Barr_virus encoded EBNA1 contributes to the growth and survival of Hodgkin_lymphoma cells .
18997174	0	PTPROt	0,6	BCR/ABL	48,55	PTPROt	BCR/ABL	5800	25;613	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells .
20564182	0	PTPROt	78,84	Lyn	58,61	PTPROt	Lyn	5800	4067	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|compound|END_ENTITY	Lyn kinase and ZAP70 are substrates of PTPROt in B-cells : Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib .
25557914	0	PTPRQ	60,65	DFNB84	71,77	PTPRQ	DFNB84	374462	374462	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural_hearing_impairment .
26851024	0	PTPRQ	5,10	PTPRZ1	60,66	PTPRQ	PTPRZ1	374462	5803	Gene	Gene	START_ENTITY|nmod|Expression Expression|nmod|END_ENTITY	High PTPRQ Expression and Its Relationship to Expression of PTPRZ1 and the Presence of KRAS Mutations in Colorectal Cancer Tissues .
26851024	0	PTPRZ1	60,66	PTPRQ	5,10	PTPRZ1	PTPRQ	5803	374462	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nmod|Expression	High PTPRQ Expression and Its Relationship to Expression of PTPRZ1 and the Presence of KRAS Mutations in Colorectal Cancer Tissues .
23170925	0	PTPRZ1	0,6	calmodulin	17,27	PTPRZ1	calmodulin	5803	808	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell_lung_carcinoma .
8790445	0	PTP_alpha	68,77	LRP	78,81	PTP alpha	LRP	19262(Tax:10090)	16971(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Regional localization of rat and mouse protein-tyrosine phosphatase PTP_alpha / LRP gene -LRB- Ptpra -RRB- by fluorescence in situ hybridization .
8790445	0	PTP_alpha	68,77	Ptpra	88,93	PTP alpha	Ptpra	19262(Tax:10090)	19262(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regional localization of rat and mouse protein-tyrosine phosphatase PTP_alpha / LRP gene -LRB- Ptpra -RRB- by fluorescence in situ hybridization .
20944008	0	PTPalpha	0,8	Lyn	19,22	PTPalpha	Lyn	19262(Tax:10090)	17096(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses .
12006995	0	PTPalpha	70,78	Src	49,52	PTPalpha	Src	19262(Tax:10090)	20779(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	-LSB- Changes of phenotypes associated with activated Src by overexpressed PTPalpha in NIH3T3 cells -RSB- .
8264566	0	PTPase	46,52	phosphotyrosine_phosphatase	17,44	PTPase	phosphotyrosine phosphatase	995	995	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Determination of phosphotyrosine_phosphatase -LRB- PTPase -RRB- activity in normal and transformed cells .
8635665	0	PTPase	55,61	phosphotyrosine_phosphatase	26,53	PTPase	phosphotyrosine phosphatase	995	995	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Decreased skeletal muscle phosphotyrosine_phosphatase -LRB- PTPase -RRB- activity towards insulin_receptors in insulin-resistant Zucker rats measured by delayed Europium fluorescence .
14676845	0	PTPgamma	82,90	protein_tyrosine_phosphatase_gamma	46,80	PTPgamma	protein tyrosine phosphatase gamma	5793	5793	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Function analysis of estrogenically regulated protein_tyrosine_phosphatase_gamma -LRB- PTPgamma -RRB- in human breast_cancer cell line MCF-7 .
17394498	0	PTPgamma	64,72	protein_tyrosine_phosphatase_gamma	28,62	PTPgamma	protein tyrosine phosphatase gamma	5793	5793	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of transmembrane protein_tyrosine_phosphatase_gamma -LRB- PTPgamma -RRB- in normal and neoplastic human tissues .
25618412	0	PTRF	0,4	caveolin_1	24,34	PTRF	caveolin 1	284119	857	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	PTRF is associated with caveolin_1 at the time of receptivity : but SDPR is absent at the same time .
20564315	0	PTRF	79,83	polymerase_1_and_transcript_release_factor	35,77	PTRF	polymerase 1 and transcript release factor	284119	284119	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Changes in caveolae , caveolin , and polymerase_1_and_transcript_release_factor -LRB- PTRF -RRB- expression in prostate_cancer progression .
7719337	0	PTS1_receptor	17,30	PXR1	37,41	PTS1 receptor	PXR1	5830	5830	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the PTS1_receptor gene , PXR1 , define complementation group 2 of the peroxisome_biogenesis_disorders .
9090383	0	PTS2_receptor	101,114	PEX7	70,74	PTS2 receptor	PEX7	5191	5191	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Rhizomelic_chondrodysplasia_punctata is caused by deficiency of human PEX7 , a homologue of the yeast PTS2_receptor .
17096843	0	PTTG	84,88	Pituitary_tumor_transforming_gene	49,82	PTTG	Pituitary tumor transforming gene	9232	9232	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of angiogenesis and invasion by human Pituitary_tumor_transforming_gene -LRB- PTTG -RRB- through increased expression and secretion of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- .
23404407	0	PTTG	49,53	pituitary_tumor_transforming_gene	14,47	PTTG	pituitary tumor transforming gene	9232	9232	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pituitary_tumor_transforming_gene -LRB- PTTG -RRB- in human pituitary_macroadenomas .
24176776	0	PTTG	53,57	pituitary_tumor_transforming_gene	18,51	PTTG	pituitary tumor transforming gene	9232	9232	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of pituitary_tumor_transforming_gene -LRB- PTTG -RRB- is associated with tumor progression and poor prognosis in patients with esophageal_squamous_cell_carcinoma .
12590639	0	PTTG	61,65	pituitary_tumour_transforming_gene	25,59	PTTG	pituitary tumour transforming gene	9232	9232	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The relationship between pituitary_tumour_transforming_gene -LRB- PTTG -RRB- expression and in vitro hormone and vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from human pituitary_adenomas .
22535767	0	PTTG-binding_factor	0,19	MCT8	82,86	PTTG-binding factor	MCT8	108705(Tax:10090)	20502(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	PTTG-binding_factor -LRB- PBF -RRB- is a novel regulator of the thyroid hormone transporter MCT8 .
24627133	0	PTTG1	0,5	SMAD3	15,20	PTTG1	SMAD3	9232	4088	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	PTTG1 inhibits SMAD3 in prostate_cancer cells to promote their proliferation .
24816985	0	PTTG1	11,16	TERT	26,30	PTTG1	TERT	9232	7015	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells .
12554778	0	PTTG1	41,46	pituitary_tumor-transforming_gene	6,39	PTTG1	pituitary tumor-transforming gene	9232	9232	Gene	Gene	motif|compound|START_ENTITY motif|amod|END_ENTITY	Human pituitary_tumor-transforming_gene -LRB- PTTG1 -RRB- motif suppresses prolactin expression .
16378119	0	PTTG1	66,71	pituitary_tumor_transforming_gene_1	29,64	PTTG1	pituitary tumor transforming gene 1	9232	9232	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	-LSB- Regulation of expression of pituitary_tumor_transforming_gene_1 -LRB- PTTG1 -RRB- by androgen in prostate_cancer -RSB- .
16619532	0	PTTG1	53,58	pituitary_tumor_transforming_gene_1	16,51	PTTG1	pituitary tumor transforming gene 1	9232	9232	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of pituitary_tumor_transforming_gene_1 -LRB- PTTG1 -RRB- in prostate_cancer .
19965758	0	PTTH	24,28	torso	64,69	PTTH	torso	33238(Tax:7227)	35717(Tax:7227)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis .
9521058	0	PTX3	59,63	Interferon-gamma	0,16	PTX3	Interferon-gamma	5806	3458	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes .
16339571	0	PTX3	32,36	JNK	83,86	PTX3	JNK	5806	5599	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK .
25049357	0	PTX3	0,4	MD-2	11,15	PTX3	MD-2	19288(Tax:10090)	17087(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis .
22529962	0	PTX3	13,17	Pentraxin_3	0,11	PTX3	Pentraxin 3	5806	5806	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pentraxin_3 -LRB- PTX3 -RRB- expression in allergic_asthmatic airways : role in airway smooth muscle migration and chemokine production .
21465531	0	PTX3	0,4	SAA	56,59	PTX3	SAA	5806	6287	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	PTX3 , a key component of innate immunity , is induced by SAA via FPRL1-mediated signaling in HAECs .
22447522	0	PTX3	43,47	SAA	17,20	PTX3	SAA	5806	6287	Gene	Gene	production|appos|START_ENTITY induces|dobj|production induces|nsubj|Serum_amyloid_A Serum_amyloid_A|appos|END_ENTITY	Serum_amyloid_A -LRB- SAA -RRB- induces pentraxin_3 -LRB- PTX3 -RRB- production in rheumatoid_synoviocytes .
16647920	0	PTX3	50,54	pentraxin_3	37,48	PTX3	pentraxin 3	5806	5806	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated maternal levels of the long pentraxin_3 -LRB- PTX3 -RRB- in preeclampsia and intrauterine_growth_restriction .
18220316	0	PTX3	27,31	pentraxin_3	14,25	PTX3	pentraxin 3	5806	5806	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pentraxin_3 -LRB- PTX3 -RRB- in human atherosclerotic_lesions .
19327124	0	PTX3	51,55	pentraxin_3	38,49	PTX3	pentraxin 3	5806	5806	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Determination of physiological plasma pentraxin_3 -LRB- PTX3 -RRB- levels in healthy populations .
23285251	0	PTX3	26,30	pentraxin_3	13,24	PTX3	pentraxin 3	5806	5806	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Influence of pentraxin_3 -LRB- PTX3 -RRB- genetic variants on myocardial_infarction risk and PTX3 plasma levels .
24652286	0	PTX3	40,44	pentraxin_3	27,38	PTX3	pentraxin 3	5806	5806	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Constitutive expression of pentraxin_3 -LRB- PTX3 -RRB- protein by human amniotic membrane cells leads to formation of the heavy chain -LRB- HC -RRB- - hyaluronan -LRB- HA -RRB- - PTX3 complex .
17229561	0	PUFA	18,22	eNOS	26,30	PUFA	eNOS	9933	4846	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells .
18579560	0	PUMA	21,25	Sp1	0,3	PUMA	Sp1	27113	6667	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Sp1 and p73 activate PUMA following serum starvation .
8514452	0	PUMP-1	20,26	MMP-7	14,19	PUMP-1	MMP-7	4316	4316	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression of MMP-7 -LRB- PUMP-1 -RRB- mRNA in human colorectal_cancers .
16969073	0	PV-1	0,4	VEGF	32,36	PV-1	VEGF	84094(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	PV-1 is negatively regulated by VEGF in the lung of caveolin-1 , but not caveolin-2 , null mice .
9521874	0	PXMP1	70,75	70-kDa_peroxisomal_membrane_protein	28,63	PXMP1	70-kDa peroxisomal membrane protein	5825	5825	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the 70-kDa_peroxisomal_membrane_protein gene -LRB- PXMP1 -RRB- .
9599016	0	PXMP1-L	108,115	peroxisomal_membrane_protein-1-like_protein	63,106	PXMP1-L	peroxisomal membrane protein-1-like protein	5826	5826	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and chromosomal localization of the human peroxisomal_membrane_protein-1-like_protein -LRB- PXMP1-L -RRB- gene encoding a peroxisomal ABC_transporter .
25285406	0	PXN	79,82	LSD1	0,4	PXN	LSD1	19303(Tax:10090)	99982(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	LSD1 controls metastasis of androgen-independent prostate_cancer cells through PXN and LPAR6 .
16085054	0	PXR	85,88	Bcl-2	14,19	PXR	Bcl-2	8856	596	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes .
17088262	0	PXR	0,3	CYP27A1	12,19	PXR	CYP27A1	8856	1593	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine .
15548381	0	PXR	2,5	CYP3A4	59,65	PXR	CYP3A4	8856	1576	Gene	Gene	assay|compound|START_ENTITY assay|dep|END_ENTITY	A PXR reporter gene assay in a stable cell culture system : CYP3A4 and CYP2B6 induction by pesticides .
18332045	0	PXR	75,78	CYP3A4	23,29	PXR	CYP3A4	8856	1576	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression dependent|nmod|regulation dependent|nsubj|induction induction|nmod|END_ENTITY	Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression .
18981011	0	PXR	0,3	CYP3A4	61,67	PXR	CYP3A4	8856	1576	Gene	Gene	pharmacogenetics|compound|START_ENTITY pharmacogenetics|dep|association association|nmod|haplotypes haplotypes|nmod|END_ENTITY	PXR pharmacogenetics : association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast_cancer patients .
19232333	0	PXR	35,38	CYP3A4	48,54	PXR	CYP3A4	8856	1576	Gene	Gene	PAR-2|compound|START_ENTITY PAR-2|nmod|expressions expressions|compound|END_ENTITY	The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions .
21641981	0	PXR	76,79	CYP3A4	22,28	PXR	CYP3A4	8856	1576	Gene	Gene	factor|compound|START_ENTITY involves|dobj|factor process|acl:relcl|involves expression|nmod|process expression|compound|END_ENTITY	Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor .
21920351	0	PXR	42,45	CYP3A4	76,82	PXR	CYP3A4	8856	1576	Gene	Gene	pregnane_X_receptor|appos|START_ENTITY pregnane_X_receptor|dep|transactivation transactivation|nmod|gene gene|compound|END_ENTITY	Metformin suppresses pregnane_X_receptor -LRB- PXR -RRB- - regulated transactivation of CYP3A4 gene .
22333269	0	PXR	109,112	CYP3A4	69,75	PXR	CYP3A4	8856	1576	Gene	Gene	overexpressed|nsubjpass|START_ENTITY conditions|acl:relcl|overexpressed impair|nmod|conditions impair|dobj|induction induction|compound|END_ENTITY	Lower expression of HNF4a and PGC1a might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells .
22363234	0	PXR	152,155	CYP3A4	61,67	PXR	CYP3A4	8856	1576	Gene	Gene	pregnane_X_receptor|appos|START_ENTITY expression|nmod|pregnane_X_receptor cytochrome_P450_3A4|dep|expression cytochrome_P450_3A4|appos|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
23330538	0	PXR	35,38	CYP3A4	49,55	PXR	CYP3A4	8856	1576	Gene	Gene	pregnane_X_receptor|appos|START_ENTITY Evaluation|nmod|pregnane_X_receptor Evaluation|dep|interactions interactions|compound|END_ENTITY	Evaluation of pregnane_X_receptor -LRB- PXR -RRB- - mediated CYP3A4 drug-drug interactions in drug development .
23845848	0	PXR	78,81	CYP3A4	49,55	PXR	CYP3A4	8856	1576	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Polycyclic_aromatic_hydrocarbons stimulate human CYP3A4 promoter activity via PXR .
25542144	0	PXR	110,113	CYP3A4	58,64	PXR	CYP3A4	8856	1576	Gene	Gene	activating|dobj|START_ENTITY induces|advcl|activating induces|dobj|expression expression|compound|END_ENTITY	Diindolylmethane , a naturally occurring compound , induces CYP3A4 and MDR1 gene expression by activating human PXR .
26341324	0	PXR	64,67	CYP3A4	78,84	PXR	CYP3A4	8856	1576	Gene	Gene	pregnane_X_receptor|appos|START_ENTITY pregnane_X_receptor|dep|END_ENTITY	A food contaminant ochratoxin_A suppresses pregnane_X_receptor -LRB- PXR -RRB- - mediated CYP3A4 induction in primary cultures of human hepatocytes .
9727070	0	PXR	34,37	CYP3A4	78,84	PXR	CYP3A4	8856	1576	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|compounds compounds|acl:relcl|regulate regulate|dobj|expression expression|compound|END_ENTITY	The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions .
15618712	0	PXR	59,62	NR1I2	52,57	PXR	NR1I2	8856	8856	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Eleven novel single nucleotide polymorphisms in the NR1I2 -LRB- PXR -RRB- gene , four of which induce non-synonymous amino_acid alterations .
21933665	0	PXR	49,52	PGC-1a	23,29	PXR	PGC-1a	8856	10891	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression modulate|nsubj|END_ENTITY	Energy sensing factors PGC-1a and SIRT1 modulate PXR expression and function .
20196838	0	PXR	21,24	Pregnane_X_Receptor	0,19	PXR	Pregnane X Receptor	8856	8856	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pregnane_X_Receptor -LRB- PXR -RRB- expression in colorectal_cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation .
16940355	0	PXR	21,24	Pregnane_X_receptor	0,19	PXR	Pregnane X receptor	18171(Tax:10090)	18171(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Pregnane_X_receptor -LRB- PXR -RRB- activation : a mechanism for neuroprotection in a mouse model of Niemann-Pick_C_disease .
25579995	0	PXR	124,127	SRC	33,36	PXR	SRC	8856	6714	Gene	Gene	Promiscuity|nmod|START_ENTITY Approach|nmod|Promiscuity Adnectins|dep|Approach Adnectins|dep|Binding Binding|compound|END_ENTITY	Developing Adnectins That Target SRC Co-Activator Binding to PXR : A Structural Approach toward Understanding Promiscuity of PXR .
25579995	0	PXR	61,64	SRC	33,36	PXR	SRC	8856	6714	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	Developing Adnectins That Target SRC Co-Activator Binding to PXR : A Structural Approach toward Understanding Promiscuity of PXR .
23527115	0	PXR	50,53	hsa-miR-148a	18,30	PXR	hsa-miR-148a	8856	406940	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	No correlation of hsa-miR-148a with expression of PXR or CYP3A4 in human livers from Chinese Han population .
26434531	0	PXR	53,56	paraoxonase_1	36,49	PXR	paraoxonase 1	8856	5444	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of human paraoxonase_1 by PXR and GR in human hepatoma cells .
20082578	0	PXR	96,99	pregnane_X_receptor	75,94	PXR	pregnane X receptor	8856	8856	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of polymorphisms in the 3 ' - untranslated region of the human pregnane_X_receptor -LRB- PXR -RRB- gene associated with variability in cytochrome_P450_3A -LRB- CYP3A -RRB- metabolism .
21402137	0	PXR	121,124	pregnane_X_receptor	100,119	PXR	pregnane X receptor	84385(Tax:10116)	84385(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	3,4-methylenedioxymethamphetamine -LRB- MDMA -RRB- interacts with therapeutic drugs on CYP3A by inhibition of pregnane_X_receptor -LRB- PXR -RRB- activation and catalytic enzyme inhibition .
21496454	0	PXR	31,34	pregnane_X_receptor	10,29	PXR	pregnane X receptor	18171(Tax:10090)	18171(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of pregnane_X_receptor -LRB- PXR -RRB- prototype agonists on chemoprotective and drug metabolizing enzymes in mice .
22829544	0	PXR	35,38	pregnane_X_receptor	14,33	PXR	pregnane X receptor	8856	8856	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of pregnane_X_receptor -LRB- PXR -RRB- function and UGT1A1 gene expression by posttranslational modification of PXR protein .
7719337	0	PXR1	37,41	PTS1_receptor	17,30	PXR1	PTS1 receptor	5830	5830	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the PTS1_receptor gene , PXR1 , define complementation group 2 of the peroxisome_biogenesis_disorders .
23743200	0	PYCR1	21,26	DJ-1	0,4	PYCR1	DJ-1	5831	11315	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	DJ-1 cooperates with PYCR1 in cell protection against oxidative stress .
26733354	0	PYCR1	0,5	RRM2B	46,51	PYCR1	RRM2B	5831	50484	Gene	Gene	Interact|nsubj|START_ENTITY Interact|nmod|END_ENTITY	PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress .
10851022	0	PYK-2	20,25	RAFTK	26,31	PYK-2	RAFTK	2185	2185	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	The tyrosine kinase PYK-2 / RAFTK regulates natural killer -LRB- NK -RRB- cell cytotoxic response , and is translocated and activated upon specific target cell recognition and killing .
11602570	0	PYK2	0,4	G_alpha_11	35,45	PYK2	G alpha 11	2185	2767	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	PYK2 as a mediator of endothelin-1 / G_alpha_11 signaling to GLUT4 glucose transporters .
9565592	0	PYK2	65,69	Leupaxin	0,8	PYK2	Leupaxin	2185	9404	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex protein|acl:relcl|forms protein|nsubj|END_ENTITY	Leupaxin is a novel LIM domain protein that forms a complex with PYK2 .
19955209	0	PYK2	0,4	MyD88	20,25	PYK2	MyD88	2185	4615	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PYK2 interacts with MyD88 and regulates MyD88-mediated NF-kappaB activation in macrophages .
12784255	0	PYK2	31,35	Prolin-rich_tyrosine_kinase_2	0,29	PYK2	Prolin-rich tyrosine kinase 2	19229(Tax:10090)	19229(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prolin-rich_tyrosine_kinase_2 -LRB- PYK2 -RRB- expression and localization in mouse testis .
15829561	0	PYK2	0,4	SERCA2	15,21	PYK2	SERCA2	50646(Tax:10116)	29693(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes .
9776731	0	PYK2	74,78	angiotensin_II	82,96	PYK2	angiotensin II	50646(Tax:10116)	24179(Tax:10116)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Calcium - and protein_kinase_C-dependent activation of the tyrosine kinase PYK2 by angiotensin_II in vascular smooth muscle .
11602570	0	PYK2	0,4	endothelin-1	22,34	PYK2	endothelin-1	2185	1906	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	PYK2 as a mediator of endothelin-1 / G_alpha_11 signaling to GLUT4 glucose transporters .
16055703	0	PYK2	85,89	plexin-B1	14,23	PYK2	plexin-B1	2185	5364	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Semaphorin_4D / plexin-B1 induces endothelial cell migration through the activation of PYK2 , Src , and the phosphatidylinositol_3-kinase-Akt pathway .
19919693	0	PYK2	56,60	proline-rich_tyrosine_kinase2	25,54	PYK2	proline-rich tyrosine kinase2	2185	2185	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Functional activation of proline-rich_tyrosine_kinase2 -LRB- PYK2 -RRB- in peripheral blood mononuclear cells from patients with systemic_lupus_erythematosus .
19433356	0	PYK2	132,136	proline-rich_tyrosine_kinase_2	100,130	PYK2	proline-rich tyrosine kinase 2	2185	2185	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich_tyrosine_kinase_2 -LRB- PYK2 -RRB- inhibitors : retrospective analysis by CYP3A4 molecular docking , quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry .
19930834	0	PYK2	61,65	proline-rich_tyrosine_kinase_2	29,59	PYK2	proline-rich tyrosine kinase 2	2185	2185	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and activation of proline-rich_tyrosine_kinase_2 -LRB- PYK2 -RRB- in peripheral blood mononuclear cells from patients with systemic_lupus_erythematosus .
24165892	0	PYL13	77,82	PP2CA	68,73	PYL13	PP2CA	827596(Tax:3702)	820314(Tax:3702)	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13 .
15096476	0	PYNOD	0,5	ASC	59,62	PYNOD	ASC	338322	29108	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	PYNOD , a novel Apaf-1 / CED4-like protein is an inhibitor of ASC and caspase-1 .
18751440	0	PYPAF3	21,27	NLRP7	14,19	PYPAF3	NLRP7	199713	199713	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Expression of NLRP7 -LRB- PYPAF3 , NALP7 -RRB- protein in endometrial_cancer tissues .
17046979	0	PYRIN-containing_Apaf-1-like_protein_1	51,89	Fas-associated_factor_1	0,23	PYRIN-containing Apaf-1-like protein 1	Fas-associated factor 1	114548	11124	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Fas-associated_factor_1 is a negative regulator of PYRIN-containing_Apaf-1-like_protein_1 .
21324568	0	PYY	149,152	GLP-1	126,131	PYY	GLP-1	5697	2641	Gene	Gene	glucagon-like_peptide-1|appos|START_ENTITY glucagon-like_peptide-1|appos|END_ENTITY	The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- and peptide_YY -LRB- PYY -RRB- .
12381516	0	PYY	40,43	PYY	52,55	PYY	PYY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats .
12381516	0	PYY	52,55	PYY	40,43	PYY	PYY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats .
18022952	0	PYY	42,45	peptide_YY	30,40	PYY	peptide YY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of brainstem peptide_YY -LRB- PYY -RRB- neurons .
2704235	0	PYY	35,38	peptide_YY	23,33	PYY	peptide YY	607156(Tax:9615)	607156(Tax:9615)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Independent release of peptide_YY -LRB- PYY -RRB- into the circulation and ileal lumen of the awake dog .
3557189	0	PYY	23,26	peptide_YY	11,21	PYY	peptide YY	5697	5697	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of peptide_YY -LRB- PYY -RRB- on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers .
6956876	0	PYY	28,31	peptide_YY	16,26	PYY	peptide YY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of peptide_YY -LRB- PYY -RRB- in gastrointestinal endocrine cells and effects on intestinal blood flow and motility .
7694325	0	PYY	43,46	peptide_YY	31,41	PYY	peptide YY	100348019(Tax:9986)	100348019(Tax:9986)	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Cyclic_AMP-mediated release of peptide_YY -LRB- PYY -RRB- from the isolated perfused rabbit distal colon .
7782089	0	PYY	47,50	peptide_YY	30,40	PYY	peptide YY	5697	5697	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Gene duplication of the human peptide_YY gene -LRB- PYY -RRB- generated the pancreatic_polypeptide gene -LRB- PPY -RRB- on chromosome 17q21 .1 .
8097274	0	PYY	103,106	peptide_YY	91,101	PYY	peptide YY	5697	5697	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Proteolytic processing by dipeptidyl_aminopeptidase_IV generates receptor selectivity for peptide_YY -LRB- PYY -RRB- -RSB- .
8559783	0	PYY	22,25	peptide_YY	10,20	PYY	peptide YY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of peptide_YY -LRB- PYY -RRB- on food-associated conflict .
1658675	0	PYY	32,35	polypeptide_YY	16,30	PYY	polypeptide YY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Acute action of polypeptide_YY -LRB- PYY -RRB- on rat adrenocortical cells : in vivo versus in vitro effects .
10681522	0	PZR	41,44	SHP-2	30,35	PZR	SHP-2	9019	5781	Gene	Gene	Dissecting|nmod|START_ENTITY Dissecting|dobj|interaction interaction|nmod|END_ENTITY	Dissecting the interaction of SHP-2 with PZR , an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs .
12410637	0	PZR	82,85	SHP-2	58,63	PZR	SHP-2	9019	5781	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor , PZR : identification , molecular cloning and effects on cell migration .
17440960	0	PZR	51,54	SHP-2	27,32	PZR	SHP-2	9019	19247(Tax:10090)	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|nsubj|ortholog ortholog|nmod|molecule molecule|compound|END_ENTITY	The murine ortholog of the SHP-2 binding molecule , PZR accelerates cell migration on fibronectin and is expressed in early embryo formation .
9792637	0	PZR	28,31	SHP-2	112,117	PZR	SHP-2	9019	5781	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and cloning of PZR , a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2 .
18568953	0	PZR	58,61	protein-zero_related	36,56	PZR	protein-zero related	9019	9019	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and localization of protein-zero_related -LRB- PZR -RRB- in cultured endothelial cells .
7645214	0	P_protein	81,90	casein_kinase_II	24,40	P protein	casein kinase II	4948	1457	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Involvement of cellular casein_kinase_II in the phosphorylation of measles_virus P_protein : identification of phosphorylation sites .
22189180	0	P_protein	87,96	neurokinin_A	55,67	P protein	neurokinin A	4948	6863	Gene	Gene	antibodies|compound|START_ENTITY antibodies|compound|END_ENTITY	The possible link between the elevated serum levels of neurokinin_A and anti-ribosomal P_protein antibodies in children with autism .
9199303	0	Pab1	6,10	Rna15	26,31	Pab1	Rna15	856912(Tax:4932)	5157776(Tax:316278)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Yeast Pab1 interacts with Rna15 and participates in the control of the poly -LRB- A -RRB- tail length in vitro .
11266443	0	Pac11p	60,66	Num1p	9,14	Pac11p	Num1p	852099(Tax:4932)	851727(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cortical Num1p interacts with the dynein intermediate chain Pac11p and cytoplasmic microtubules in budding yeast .
26048990	0	Paf1	45,49	Ctr9	0,4	Paf1	Ctr9	54623	9646	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Ctr9 , a protein in the transcription complex Paf1 , regulates dopamine_transporter activity at the plasma membrane .
26384244	0	Paf1	24,28	SKIP	0,4	Paf1	SKIP	834290(Tax:3702)	844055(Tax:3702)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	SKIP Interacts with the Paf1 Complex to Regulate Flowering via the Activation of FLC Transcription in Arabidopsis .
9697693	0	Pafah1b1	20,28	Lis1	30,34	Pafah1b1	Lis1	18472(Tax:10090)	18472(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Graded reduction of Pafah1b1 -LRB- Lis1 -RRB- activity results in neuronal migration defects and early embryonic_lethality .
25117580	0	Pah1	16,20	TORC1	0,5	Pah1	TORC1	855201(Tax:4932)	23373	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex .
25266661	0	Paip1	0,5	WWP2	73,77	Paip1	WWP2	10605	80014	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Paip1 , an effective stimulator of translation initiation , is targeted by WWP2 for ubiquitination and degradation .
25568256	0	Paip1	26,31	WWP2	99,103	Paip1	WWP2	10605	11060	Gene	Gene	Targeted|nsubjpass|START_ENTITY Targeted|nmod|END_ENTITY	Correction for Lv et al. , Paip1 , an Effective Stimulator of Translation Initiation , Is Targeted by WWP2 for Ubiquitination and Degradation .
22644304	0	Pair-Box	0,8	PAX8	10,14	Pair-Box	PAX8	7849	7849	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pair-Box -LRB- PAX8 -RRB- protein-positive expression is associated with poor disease outcome in women with endometrial_cancer .
10327049	0	Paired_immunoglobulin-like_receptor_B	0,37	SHP-1	96,101	Paired immunoglobulin-like receptor B	SHP-1	11025	8431	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Paired_immunoglobulin-like_receptor_B -LRB- PIR-B -RRB- inhibits BCR-induced activation of Syk and Btk by SHP-1 .
22981863	0	Pak1	83,87	Erk	16,19	Pak1	Erk	5058	5594	Gene	Gene	activation|dep|START_ENTITY activation|compound|END_ENTITY	LAT-independent Erk activation via Bam32-PLC-y1-Pak1 complexes : GTPase-independent Pak1 activation .
8798379	0	Pak1	89,93	Nck	20,23	Pak1	Nck	5058	4690	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1 .
26898755	0	Pak1	42,46	RUNX3	33,38	Pak1	RUNX3	18479(Tax:10090)	12399(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions .
22751929	0	Pak1	132,136	SKIP	91,95	Pak1	SKIP	5058	51763	Gene	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	Regulation of insulin signaling by the phosphatidylinositol_3 ,4,5 - triphosphate phosphatase SKIP through the scaffolding function of Pak1 .
15833848	0	Pak1	0,4	snail	100,105	Pak1	snail	5058	6615	Gene	Gene	phosphorylation|amod|START_ENTITY modulates|nsubj|phosphorylation modulates|dobj|localization localization|nmod:poss|END_ENTITY	Pak1 phosphorylation of snail , a master regulator of epithelial-to-mesenchyme transition , modulates snail 's subcellular localization and functions .
15833848	0	Pak1	0,4	snail	24,29	Pak1	snail	5058	6615	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pak1 phosphorylation of snail , a master regulator of epithelial-to-mesenchyme transition , modulates snail 's subcellular localization and functions .
11070003	0	Pak2	38,42	Nef	11,14	Pak2	Nef	5062	6285	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Lentivirus Nef specifically activates Pak2 .
9823899	0	Pak3	19,23	Raf-1	45,50	Pak3	Raf-1	5063	5894	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 .
23657012	0	Palb2	0,5	Trp53	22,27	Palb2	Trp53	233826(Tax:10090)	22059(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Palb2 synergizes with Trp53 to suppress mammary_tumor formation in a model of inherited_breast_cancer .
16868024	0	Palladin	0,8	Eps8	18,22	Palladin	Eps8	27143	2059	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells .
24810057	0	Palmdelphin	0,11	p53	31,34	Palmdelphin	p53	54873	7157	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Palmdelphin , a novel target of p53 with Ser46 phosphorylation , controls cell death in response to DNA damage .
15218029	1	Pam16	77,82	Pam18	122,127	Pam16	Pam18	51025	131118	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Pam16 functions in an antagonistic manner to Pam18 .
22031295	0	Pam16	38,43	Pam18	32,37	Pam16	Pam18	51025	131118	Gene	Gene	interaction|amod|START_ENTITY Reevaluation|dep|interaction Reevaluation|nmod|role role|nmod|END_ENTITY	Reevaluation of the role of the Pam18 : Pam16 interaction in translocation of proteins by the mitochondrial Hsp70-based import motor .
15218029	1	Pam18	122,127	Pam16	77,82	Pam18	Pam16	131118	51025	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Pam16 functions in an antagonistic manner to Pam18 .
22031295	0	Pam18	32,37	Pam16	38,43	Pam18	Pam16	131118	51025	Gene	Gene	role|nmod|START_ENTITY Reevaluation|nmod|role Reevaluation|dep|interaction interaction|amod|END_ENTITY	Reevaluation of the role of the Pam18 : Pam16 interaction in translocation of proteins by the mitochondrial Hsp70-based import motor .
2134219	0	Pancreastatin	0,13	insulin	23,30	Pancreastatin	insulin	397540(Tax:9823)	397415(Tax:9823)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Pancreastatin inhibits insulin secretion and exocrine pancreatic secretion in the pig .
12972592	0	Pancreatic-duodenal_homeobox_1	0,30	liver_receptor_homolog_1	55,79	Pancreatic-duodenal homeobox 1	liver receptor homolog 1	18609(Tax:10090)	26424(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Pancreatic-duodenal_homeobox_1 regulates expression of liver_receptor_homolog_1 during pancreas development .
21196815	0	Pancreatic_adenocarcinoma_up-regulated_factor	0,45	b-catenin	80,89	Pancreatic adenocarcinoma up-regulated factor	b-catenin	124220	1499	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Pancreatic_adenocarcinoma_up-regulated_factor -LRB- PAUF -RRB- enhances the expression of b-catenin , leading to a rapid proliferation of pancreatic cells .
21537415	0	Pancreatic_and_Duodenal_Homeobox_1	68,102	INS-1	106,111	Pancreatic and Duodenal Homeobox 1	INS-1	29535(Tax:10116)	24505(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Decreased Expression and Induced Nucleocytoplasmic Translocation of Pancreatic_and_Duodenal_Homeobox_1 in INS-1 Cells Exposed to High Glucose and Palmitate .
20637728	0	Pancreatic_and_duodenal_homeobox_1	0,34	PDX1	36,40	Pancreatic and duodenal homeobox 1	PDX1	18609(Tax:10090)	18609(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Pancreatic_and_duodenal_homeobox_1 -LRB- PDX1 -RRB- phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization .
19451396	0	Pancreatic_lipase-related_protein_2	0,35	IL-4	57,61	Pancreatic lipase-related protein 2	IL-4	5408	3565	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|END_ENTITY	Pancreatic_lipase-related_protein_2 -LRB- PLRP2 -RRB- induction by IL-4 in cytotoxic T lymphocytes -LRB- CTLs -RRB- and reevaluation of the negative effects of its gene ablation on cytotoxicity .
3042579	0	Pancreatic_polypeptide	0,22	secretin	35,43	Pancreatic polypeptide	secretin	5539	6343	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Pancreatic_polypeptide response to secretin in obesity : effects of glucose_intolerance .
25019573	0	Pancreatic_polypeptide	0,22	somatostatin	32,44	Pancreatic polypeptide	somatostatin	19064(Tax:10090)	20604(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Pancreatic_polypeptide inhibits somatostatin secretion .
12095677	0	Pank1	32,37	pantothenate_kinase	11,30	Pank1	pantothenate kinase	75735(Tax:10090)	75735(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The murine pantothenate_kinase -LRB- Pank1 -RRB- gene encodes two differentially regulated pantothenate_kinase isozymes .
17036048	0	Pannexin-1	0,10	P2X7_receptor	88,101	Pannexin-1	P2X7 receptor	24145	5027	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7_receptor .
26553756	0	Pannexin-1	0,10	RANKL	95,100	Pannexin-1	RANKL	55991(Tax:10090)	21943(Tax:10090)	Gene	Gene	Required|nsubjpass|START_ENTITY Required|nmod|Production Production|compound|END_ENTITY	Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes .
21915903	0	Pannexin_3	0,10	Runx2	33,38	Pannexin 3	Runx2	208098(Tax:10090)	12393(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Pannexin_3 is a novel target for Runx2 , expressed by osteoblasts and mature growth plate chondrocytes .
16758184	0	Pantothenate_kinase_2	0,21	pantothenate-kinase-associated_neurodegeneration	44,92	Pantothenate kinase 2	pantothenate-kinase-associated neurodegeneration	80025	80025	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|END_ENTITY	Pantothenate_kinase_2 mutation with classic pantothenate-kinase-associated_neurodegeneration without ` eye-of-the-tiger ' sign on MRI in a pair of siblings .
16275122	0	Panza	14,19	alpha2-macroglobulin	24,44	Panza	alpha2-macroglobulin	100189580(Tax:8355)	100158443(Tax:8355)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Panza , an alpha2-macroglobulin , in a restricted dorsal domain of the primitive gut in Xenopus_laevis .
20197085	0	PappA	106,111	pregnancy-associated_plasma_protein_A	67,104	PappA	pregnancy-associated plasma protein A	18491(Tax:10090)	18491(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated_plasma_protein_A -LRB- PappA -RRB- gene .
22394585	0	Papss2	51,57	TGF-b	26,31	Papss2	TGF-b	23972(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Altered responsiveness to TGF-b results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage .
22326025	0	Par-1	0,5	myosin-II	15,24	Par-1	myosin-II	2768852(Tax:7227)	31554(Tax:7227)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|activity activity|amod|END_ENTITY	Par-1 controls myosin-II activity through myosin_phosphatase to regulate border cell migration .
22326025	0	Par-1	0,5	myosin_phosphatase	42,60	Par-1	myosin phosphatase	2768852(Tax:7227)	49070(Tax:7227)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Par-1 controls myosin-II activity through myosin_phosphatase to regulate border cell migration .
11084032	0	Par-1	69,74	thrombin	11,19	Par-1	thrombin	145624	2147	Gene	Gene	hydrolysis|nmod|START_ENTITY accelerates|dobj|hydrolysis accelerates|nsubj|Binding Binding|nmod|END_ENTITY	Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets .
19189342	0	Par-1	73,78	thrombin	39,47	Par-1	thrombin	2149	2147	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase .
20619750	0	Par-3	12,17	ASPP2	0,5	Par-3	ASPP2	56288	7159	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development .
21949390	0	Par-3	84,89	Sir-two-homolog_2	0,17	Par-3	Sir-two-homolog 2	112235(Tax:10090)	64383(Tax:10090)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Sir-two-homolog_2 -LRB- Sirt2 -RRB- modulates peripheral myelination through polarity protein Par-3 / atypical_protein_kinase_C -LRB- aPKC -RRB- signaling .
15723052	0	Par-3	0,5	Tiam1	71,76	Par-3	Tiam1	56288	7074	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Par-3 controls tight junction assembly through the Rac exchange factor Tiam1 .
17082460	0	Par-3	21,26	p75NTR	51,57	Par-3	p75NTR	2151	4804	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The polarity protein Par-3 directly interacts with p75NTR to regulate myelination .
18650932	0	Par-4	0,5	Akt	15,18	Par-4	Akt	114774(Tax:10090)	11651(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis .
18769154	0	Par-4	94,99	Akt	0,3	Par-4	Akt	347745	207	Gene	Gene	action|nmod|START_ENTITY role|nmod|action regulation|dep|role regulation|compound|END_ENTITY	Akt regulation and lung_cancer : a novel role and mechanism of action for the tumor suppressor Par-4 .
12644474	0	Par-4	0,5	Bcl-2	34,39	Par-4	Bcl-2	5074	596	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter .
19625447	0	Par-4	0,5	DAP-like_kinase	43,58	Par-4	DAP-like kinase	64513(Tax:10116)	64391(Tax:10116)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Par-4 is an essential downstream target of DAP-like_kinase -LRB- Dlk -RRB- in Dlk/Par -4 - mediated apoptosis .
19250735	0	Par-4	72,77	LMP-1	4,9	Par-4	LMP-1	5074	9260	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal_carcinoma cells .
12170775	0	Par-4	0,5	NF_kappa_B	56,66	Par-4	NF kappa B	347745	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Par-4 , a pro-apoptotic gene , inhibits radiation-induced NF_kappa_B activity and Bcl-2 expression leading to induction of radiosensitivity in human prostate_cancer cells PC-3 .
20735158	0	Par-4	37,42	PAWR	44,48	Par-4	PAWR	5074	5074	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence of involvement of the human Par-4 -LRB- PAWR -RRB- gene in major_depressive_disorder .
25969134	0	Par-4	0,5	b-catenin	39,48	Par-4	b-catenin	347745	1499	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Par-4 dependent modulation of cellular b-catenin by medicinal plant natural product derivative 3-azido_Withaferin_A .
20082875	0	Par-4	43,48	prostate_apoptosis_response	14,41	Par-4	prostate apoptosis response	5074	5074	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of prostate_apoptosis_response -LRB- Par-4 -RRB- is associated with progesterone_receptor in breast_cancer .
17219052	0	Par-4	71,76	prostate_apoptosis_response_protein_4	32,69	Par-4	prostate apoptosis response protein 4	64513(Tax:10116)	64513(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of the expression of prostate_apoptosis_response_protein_4 -LRB- Par-4 -RRB- in rat granulosa cells .
18676842	0	Par-4	0,5	topoisomerase_1	15,30	Par-4	topoisomerase 1	5074	7150	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Par-4 binds to topoisomerase_1 and attenuates its DNA relaxation activity .
23720771	0	Par14	0,5	insulin_receptor_substrate_1	30,58	Par14	insulin receptor substrate 1	69713(Tax:10090)	16367(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Par14 protein associates with insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- , thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions .
14653998	0	Par3	68,72	14-3-3	37,43	Par3	14-3-3	56288	10971	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia .
10934474	0	Par3	37,41	Par6	26,30	Par3	Par6	175783(Tax:6239)	173137(Tax:6239)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 .
25657002	0	Par3	29,33	Stat3	44,49	Par3	Stat3	112235(Tax:10090)	20848(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Loss of the Polarity Protein Par3 Activates Stat3 Signaling via an aPKC/NF-kB/IL -6 Axis in Mouse Mammary Cells .
26084985	0	Par3	0,4	Tiam1	72,77	Par3	Tiam1	56288	7074	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Par3 regulates invasion of pancreatic_cancer cells via interaction with Tiam1 .
14718572	0	Par6	23,27	CRB3	0,4	Par6	CRB3	100506965	92359	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells .
10934474	0	Par6	26,30	Cdc42	75,80	Par6	Cdc42	173137(Tax:6239)	174233(Tax:6239)	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 .
10934474	0	Par6	26,30	Par3	37,41	Par6	Par3	173137(Tax:6239)	175783(Tax:6239)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42 .
15761148	0	Par6	35,39	TGFbeta	43,50	Par6	TGFbeta	100506965	7040	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity .
23762244	0	Par6C	70,75	RhoA	54,58	Par6C	RhoA	50855	387	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis .
18343818	0	Par6c	91,96	RhoA	111,115	Par6c	RhoA	50855	387	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Transforming_growth_factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA .
12828644	0	ParF	20,24	ParG	25,29	ParF	ParG	55684	8505	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Architecture of the ParF * ParG protein complex involved in prokaryotic DNA segregation .
12828644	0	ParG	25,29	ParF	20,24	ParG	ParF	8505	55684	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Architecture of the ParF * ParG protein complex involved in prokaryotic DNA segregation .
26720603	0	Paramyosin	21,31	C1q	55,58	Paramyosin	C1q	10913117	712	Gene	Gene	Binds|nsubj|START_ENTITY Binds|dobj|END_ENTITY	Trichinella_spiralis Paramyosin Binds Human Complement C1q and Inhibits Classical Complement Activation .
2754728	0	Paramyosin	0,10	unc-15	17,23	Paramyosin	unc-15	172491(Tax:6239)	172491(Tax:6239)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Paramyosin gene -LRB- unc-15 -RRB- of Caenorhabditis_elegans .
11472729	0	Paraoxonase	0,11	PON1	22,26	Paraoxonase	PON1	5444	5444	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Paraoxonase producing PON1 gene M/L55 polymorphism is related to autopsy-verified artery-wall atherosclerosis .
17704557	0	Paraoxonase	0,11	PON1	13,17	Paraoxonase	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Paraoxonase -LRB- PON1 -RRB- activity in north west Indian Punjabis with coronary_artery_disease _ type_2_diabetes_mellitus .
24700021	0	Paraoxonase	0,11	PON1	13,17	Paraoxonase	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Paraoxonase -LRB- PON1 -RRB- activity in patients with subclinical thoracic aortic atherosclerosis .
9170151	0	Paraoxonase	0,11	PON1	13,17	Paraoxonase	PON1	18979(Tax:10090)	18979(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Paraoxonase -LRB- PON1 -RRB- gene in mice : sequencing , chromosomal localization and developmental expression .
17032132	0	Paraoxonase-1	0,13	PON1	15,19	Paraoxonase-1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Paraoxonase-1 -LRB- PON1 -RRB- activity , but not PON1 -LRB- Q192R -RRB- phenotype , is a predictor of coronary_artery_disease in a middle-aged Serbian population .
23438848	0	Paraoxonase-1	0,13	PON1	15,19	Paraoxonase-1	PON1	5444	5444	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Paraoxonase-1 -LRB- PON1 -RRB- status in pancreatic_cancer : relation to clinical parameters .
9329371	0	Paraoxonase-2	0,13	PON2	20,24	Paraoxonase-2	PON2	5445	5445	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Paraoxonase-2 gene -LRB- PON2 -RRB- G148 variant associated with elevated fasting plasma glucose_in_noninsulin-dependent_diabetes_mellitus .
18423402	0	Paraoxonase_1	0,13	PON1	15,19	Paraoxonase 1	PON1	5444	5444	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- status in gastroesophageal_malignancies and associated paraneoplastic syndromes - connection with inflammation .
19071155	0	Paraoxonase_1	0,13	PON1	15,19	Paraoxonase 1	PON1	5444	5444	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- status and substrate hydrolysis .
19783251	0	Paraoxonase_1	0,13	PON1	15,19	Paraoxonase 1	PON1	5444	5444	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Paraoxonase_1 -LRB- PON1 -RRB- expression in hepatocytes is upregulated by pomegranate polyphenols : a role for PPAR-gamma pathway .
20348046	0	Paraoxonase_1	1,14	PON1	16,20	Paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Paraoxonase_1 -LRB- PON1 -RRB- activity and lipid parameters in Tunisian smokers -RSB- .
20390392	0	Paraoxonase_1	25,38	PON1	40,44	Paraoxonase 1	PON1	5444	5444	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Genetic Polymorphisms of Paraoxonase_1 -LRB- PON1 -RRB- Gene : Association Between L55M or Q192R with Breast_Cancer Risk and Clinico-Pathological Parameters .
20532959	0	Paraoxonase_1	21,34	PON1	36,40	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Relationship between Paraoxonase_1 -LRB- PON1 -RRB- gene polymorphisms and susceptibility of stroke : a meta-analysis .
24589953	0	Paraoxonase_1	23,36	PON1	38,42	Paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The predictive role of Paraoxonase_1 -LRB- PON1 -RRB- activity on survival in patients with metastatic and nonmetastatic gastric_cancer .
25734763	0	Paraoxonase_1	53,66	PON1	68,72	Paraoxonase 1	PON1	5444	5444	Gene	Gene	Status|compound|START_ENTITY Status|appos|END_ENTITY	Determination of the Genotype and Phenotype of Serum Paraoxonase_1 -LRB- PON1 -RRB- Status in a Group of Agricultural and Nonagricultural Workers in the Coquimbo Region , Chile .
20944437	0	Paraoxonase_1	0,13	butyrylcholinesterase	30,51	Paraoxonase 1	butyrylcholinesterase	5444	590	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Paraoxonase_1 correlates with butyrylcholinesterase and gamma_glutamyl_transferase in workers chronically exposed to pesticides .
15544923	0	Paraoxonase_2	0,13	PON2	15,19	Paraoxonase 2	PON2	330260(Tax:10090)	330260(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Paraoxonase_2 -LRB- PON2 -RRB- expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate -LRB- NADPH -RRB- - oxidase-dependent mechanism during monocytes differentiation into macrophages .
25158085	0	Parathyroid_Hormone	30,49	PTH	51,54	Parathyroid Hormone	PTH	5741	5741	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	N-Terminal Phosphorylation of Parathyroid_Hormone -LRB- PTH -RRB- Abolishes Its Receptor Activity .
19078166	0	Parathyroid_Hormone_Related_Peptide	8,43	PTHrP	45,50	Parathyroid Hormone Related Peptide	PTHrP	5744	5744	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Parathyroid_Hormone_Related_Peptide -LRB- PTHrP -RRB- in Hypercalcemia_of_Malignancy and the Development of Osteolytic Metastases .
25529820	0	Parathyroid_Hormone_Type_1_Receptor	12,47	PTH1R	49,54	Parathyroid Hormone Type 1 Receptor	PTH1R	5745	5745	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the Parathyroid_Hormone_Type_1_Receptor -LRB- PTH1R -RRB- as a Mechanosensor in Osteocyte Survival .
12496250	0	Parathyroid_hormone	0,19	A_kinase_anchoring_protein	93,119	Parathyroid hormone	A kinase anchoring protein	5741	11214	Gene	Gene	regulation|amod|START_ENTITY dependent|nsubj|regulation dependent|nmod|END_ENTITY	Parathyroid_hormone regulation of type II sodium-phosphate cotransporters is dependent on an A_kinase_anchoring_protein .
19672814	0	Parathyroid_hormone	0,19	BMP-2	32,37	Parathyroid hormone	BMP-2	19226(Tax:10090)	12156(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Parathyroid_hormone upregulates BMP-2 mRNA expression through mevalonate_kinase and Rho kinase inhibition in osteoblastic MC3T3-E1 cells .
21245057	0	Parathyroid_hormone	0,19	CXCR4	79,84	Parathyroid hormone	CXCR4	19226(Tax:10090)	12767(Tax:10090)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Parathyroid_hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4 -LRB- + -RRB- stem cells into the ischaemic heart .
21245057	0	Parathyroid_hormone	0,19	DPP-IV	25,31	Parathyroid hormone	DPP-IV	19226(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Parathyroid_hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4 -LRB- + -RRB- stem cells into the ischaemic heart .
15087429	0	Parathyroid_hormone	0,19	E4bp4	28,33	Parathyroid hormone	E4bp4	19226(Tax:10090)	18030(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Parathyroid_hormone induces E4bp4 messenger ribonucleic acid expression primarily through cyclic_adenosine_3 ' ,5 ' - monophosphate signaling in osteoblasts .
19384851	0	Parathyroid_hormone	0,19	ERK1/2	88,94	Parathyroid hormone	ERK1/2	24694(Tax:10116)	50689;116590	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|phosphorylation phosphorylation|nmod|kinase kinase|acl|END_ENTITY	Parathyroid_hormone inhibits phosphorylation of mitogen-activated protein kinase -LRB- MAPK -RRB- ERK1/2 through inhibition of c-Raf and activation of MKP-1 in osteoblastic cells .
14691682	0	Parathyroid_hormone	0,19	MT1-MMP	89,96	Parathyroid hormone	MT1-MMP	5741	4323	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Parathyroid_hormone inhibits the expression of membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- in osteoblast-like MG-63 cells .
12788080	0	Parathyroid_hormone	0,19	NOR-1	56,61	Parathyroid hormone	NOR-1	19226(Tax:10090)	18124(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Parathyroid_hormone induces the nuclear orphan receptor NOR-1 in osteoblasts .
24940803	0	Parathyroid_hormone	0,19	Nurr1	58,63	Parathyroid hormone	Nurr1	24694(Tax:10116)	54278(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Parathyroid_hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription .
16325485	0	Parathyroid_hormone	0,19	PKC-delta	30,39	Parathyroid hormone	PKC-delta	19226(Tax:10090)	18753(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Parathyroid_hormone activates PKC-delta and regulates osteoblastic differentiation via a PLC-independent pathway .
7649096	0	Parathyroid_hormone	0,19	PTH	130,133	Parathyroid hormone	PTH	399502(Tax:9823)	399502(Tax:9823)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related peptide receptor density modulates activation of phospholipase C and phosphate transport by PTH in LLC-PK1 cells .
9231754	0	Parathyroid_hormone	0,19	PTH	21,24	Parathyroid hormone	PTH	24694(Tax:10116)	5741	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH 1-34 -RRB- regulation of rat osteocalcin gene transcription .
7599071	0	Parathyroid_hormone	0,19	PTH-related_protein	26,45	Parathyroid hormone	PTH-related protein	5741	5744	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
22338074	0	Parathyroid_hormone	0,19	PTHR1	72,77	Parathyroid hormone	PTHR1	19226(Tax:10090)	19228(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|formation formation|nmod|mice mice|compound|END_ENTITY	Parathyroid_hormone induces bone formation in phosphorylation-deficient PTHR1 knockin mice .
7599071	0	Parathyroid_hormone	0,19	PTHrP	47,52	Parathyroid hormone	PTHrP	5741	5744	Gene	Gene	START_ENTITY|dep|expression expression|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor expression and mitogenic responses in human breast_cancer cell lines .
8070351	0	Parathyroid_hormone	0,19	PTHrP	47,52	Parathyroid hormone	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	/|nsubj|START_ENTITY /|dobj|receptor receptor|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- receptor and its messenger ribonucleic_acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells : cell-specific regulation by angiotensin-II and PTHrP .
11996904	0	Parathyroid_hormone	0,19	RGS-2	28,33	Parathyroid hormone	RGS-2	19226(Tax:10090)	19735(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Parathyroid_hormone induces RGS-2 expression by a cyclic_adenosine_3 ' ,5 ' - monophosphate-mediated pathway in primary neonatal murine osteoblasts .
16484320	0	Parathyroid_hormone	0,19	Smad3	58,63	Parathyroid hormone	Smad3	19226(Tax:10090)	17127(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Parathyroid_hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells .
10433211	0	Parathyroid_hormone	0,19	TRANCE	31,37	Parathyroid hormone	TRANCE	19226(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Parathyroid_hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures : correlation with osteoclast-like cell formation .
19423690	0	Parathyroid_hormone	0,19	TRPV5	30,35	Parathyroid hormone	TRPV5	5741	56302	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Parathyroid_hormone activates TRPV5 via PKA-dependent phosphorylation .
1480173	0	Parathyroid_hormone	0,19	c-fos	28,33	Parathyroid hormone	c-fos	24694(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|RNA RNA|amod|END_ENTITY	Parathyroid_hormone induces c-fos and c-jun messenger RNA in rat osteoblastic cells .
8275957	0	Parathyroid_hormone	0,19	c-fos	39,44	Parathyroid hormone	c-fos	5741	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Parathyroid_hormone induces sequential c-fos expression in bone cells in vivo : in situ localization of its receptor and c-fos messenger ribonucleic acids .
8810350	0	Parathyroid_hormone	0,19	c-fos	28,33	Parathyroid hormone	c-fos	5741	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Parathyroid_hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element -LRB- CRE -RRB- - binding protein binding to the major CRE .
10671545	0	Parathyroid_hormone	0,19	collagenase-3	42,55	Parathyroid hormone	collagenase-3	24694(Tax:10116)	171052(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	Parathyroid_hormone regulation of the rat collagenase-3 promoter by protein_kinase_A-dependent transactivation of core_binding_factor_alpha1 .
10671545	0	Parathyroid_hormone	0,19	core_binding_factor_alpha1	114,140	Parathyroid hormone	core binding factor alpha1	24694(Tax:10116)	367218(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Parathyroid_hormone regulation of the rat collagenase-3 promoter by protein_kinase_A-dependent transactivation of core_binding_factor_alpha1 .
19821778	0	Parathyroid_hormone	0,19	cyclooxygenase-2	33,49	Parathyroid hormone	cyclooxygenase-2	19226(Tax:10090)	19225(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Parathyroid_hormone induction of cyclooxygenase-2 in murine osteoblasts : role of the calcium-calcineurin-NFAT pathway .
17545677	0	Parathyroid_hormone	0,19	endothelial_nitric_oxide_synthase	35,68	Parathyroid hormone	endothelial nitric oxide synthase	5741	4846	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Parathyroid_hormone stimulates the endothelial_nitric_oxide_synthase through protein kinase A and C pathways .
18518931	0	Parathyroid_hormone	0,19	endothelin-1	44,56	Parathyroid hormone	endothelin-1	5741	1906	Gene	Gene	related|nsubjpass|START_ENTITY related|xcomp|END_ENTITY	Parathyroid_hormone is inversely related to endothelin-1 in patients on haemodialysis .
11316763	0	Parathyroid_hormone	0,19	fra-2	31,36	Parathyroid hormone	fra-2	19226(Tax:10090)	14284(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Parathyroid_hormone stimulates fra-2 expression in osteoblastic cells in vitro and in vivo .
9844102	0	Parathyroid_hormone	0,19	inducible_cAMP_early_repressor	46,76	Parathyroid hormone	inducible cAMP early repressor	19226(Tax:10090)	12916(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Parathyroid_hormone induces expression of the inducible_cAMP_early_repressor in osteoblastic MC3T3-E1 cells and mouse calvariae .
2759029	0	Parathyroid_hormone	0,19	insulin-like_growth_factor-I	42,70	Parathyroid hormone	insulin-like growth factor-I	19226(Tax:10090)	16000(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Parathyroid_hormone stimulates release of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-II from neonatal mouse calvaria in organ culture .
11171594	0	Parathyroid_hormone	0,19	interleukin-6	60,73	Parathyroid hormone	interleukin-6	24694(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Parathyroid_hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor .
12185323	0	Parathyroid_hormone	0,19	interleukin-6	28,41	Parathyroid hormone	interleukin-6	24694(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Parathyroid_hormone induces interleukin-6 gene expression in bone stromal cells of young rats .
21048959	0	Parathyroid_hormone	0,19	interleukin-6	66,79	Parathyroid hormone	interleukin-6	19226(Tax:10090)	16193(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	Parathyroid_hormone mediates hematopoietic cell expansion through interleukin-6 .
2548501	0	Parathyroid_hormone	0,19	interleukin-6	128,141	Parathyroid hormone	interleukin-6	24694(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|nmod|cells cells|dep|role role|nmod|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- and PTH-like_protein -LRB- PLP -RRB- stimulate interleukin-6 production by osteogenic cells : a possible role of interleukin-6 in osteoclastogenesis .
2548501	0	Parathyroid_hormone	0,19	interleukin-6	63,76	Parathyroid hormone	interleukin-6	24694(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|production production|amod|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- and PTH-like_protein -LRB- PLP -RRB- stimulate interleukin-6 production by osteogenic cells : a possible role of interleukin-6 in osteoclastogenesis .
9328832	0	Parathyroid_hormone	0,19	interleukin-6	36,49	Parathyroid hormone	interleukin-6	5741	3569	Gene	Gene	START_ENTITY|acl|mediated mediated|dobj|induction induction|amod|END_ENTITY	Parathyroid_hormone -LRB- 1-34 -RRB- - mediated interleukin-6 induction .
9763144	0	Parathyroid_hormone	0,19	interleukin-6	28,41	Parathyroid hormone	interleukin-6	19226(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|expression expression|nsubj|nuclear nuclear|amod|END_ENTITY	Parathyroid_hormone induces interleukin-6 heterogeneous nuclear and messenger RNA expression in murine calvarial organ cultures .
10433211	0	Parathyroid_hormone	0,19	osteoprotegerin	51,66	Parathyroid hormone	osteoprotegerin	19226(Tax:10090)	18383(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Parathyroid_hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures : correlation with osteoclast-like cell formation .
18945829	0	Parathyroid_hormone	0,19	osteoprotegerin	42,57	Parathyroid hormone	osteoprotegerin	5741	4982	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|secretion secretion|compound|END_ENTITY	Parathyroid_hormone decreases endothelial osteoprotegerin secretion : role of protein kinase A and C. Parathyroid_hormone -LRB- PTH -RRB- , which is elevated in patients with chronic_renal_failure , has been shown to participate in the development of vascular_calcification .
16610234	0	Parathyroid_hormone	0,19	osterix	30,37	Parathyroid hormone	osterix	24694(Tax:10116)	300260(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Parathyroid_hormone regulates osterix and Runx2 mRNA expression predominantly through protein_kinase_A signaling in osteoblast-like cells .
16610234	0	Parathyroid_hormone	0,19	protein_kinase_A	86,102	Parathyroid hormone	protein kinase A	24694(Tax:10116)	25636(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Parathyroid_hormone regulates osterix and Runx2 mRNA expression predominantly through protein_kinase_A signaling in osteoblast-like cells .
16075364	0	Parathyroid_hormone	0,19	receptor_activity_modifying_protein-3	28,65	Parathyroid hormone	receptor activity modifying protein-3	19226(Tax:10090)	56089(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Parathyroid_hormone induces receptor_activity_modifying_protein-3 -LRB- RAMP3 -RRB- expression primarily via 3 ' ,5 ' - cyclic_adenosine_monophosphate signaling in osteoblasts .
1714830	0	Parathyroid_hormone	0,19	renin	64,69	Parathyroid hormone	renin	24694(Tax:10116)	24715(Tax:10116)	Gene	Gene	START_ENTITY|dep|interactions interactions|nmod|control control|nmod|secretion secretion|compound|END_ENTITY	Parathyroid_hormone and calcium : interactions in the control of renin secretion in the isolated , nonfiltering rat kidney .
15769857	0	Parathyroid_hormone	0,19	vitamin_D_receptor	36,54	Parathyroid hormone	vitamin D receptor	19226(Tax:10090)	22337(Tax:10090)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	Parathyroid_hormone decreases renal vitamin_D_receptor expression in vivo .
15302580	0	Parathyroid_hormone-related_peptide	0,35	Runx2	53,58	Parathyroid hormone-related peptide	Runx2	396281(Tax:9031)	373919(Tax:9031)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Parathyroid_hormone-related_peptide -LRB- PTHrP -RRB- inhibits Runx2 expression through the PKA signaling pathway .
12960089	0	Parathyroid_hormone-related_peptide	0,35	bone_morphogenetic_protein_2	51,79	Parathyroid hormone-related peptide	bone morphogenetic protein 2	19227(Tax:10090)	12156(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Parathyroid_hormone-related_peptide interacts with bone_morphogenetic_protein_2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells .
17468516	0	Parathyroid_hormone-related_protein	0,35	Akt	105,108	Parathyroid hormone-related protein	Akt	5744	207	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Parathyroid_hormone-related_protein induces cell survival in human renal_cell_carcinoma through the PI3K Akt pathway : evidence for a critical role for integrin-linked_kinase and nuclear_factor_kappa_B .
17443683	0	Parathyroid_hormone-related_protein	0,35	CK2	95,98	Parathyroid hormone-related protein	CK2	5744	13000(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- inhibits mitochondrial-dependent apoptosis through CK2 .
17468516	0	Parathyroid_hormone-related_protein	0,35	PI3K	100,104	Parathyroid hormone-related protein	PI3K	5744	5293	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	Parathyroid_hormone-related_protein induces cell survival in human renal_cell_carcinoma through the PI3K Akt pathway : evidence for a critical role for integrin-linked_kinase and nuclear_factor_kappa_B .
11595209	0	Parathyroid_hormone-related_protein	0,35	PTHrP	37,42	Parathyroid hormone-related protein	PTHrP	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- induction in reactive astrocytes following brain_injury : a possible mediator of CNS inflammation .
15800941	0	Parathyroid_hormone-related_protein	0,35	PTHrP	120,125	Parathyroid hormone-related protein	PTHrP	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- as a causative factor of cancer-associated wasting : possible involvement of PTHrP in the repression of locomotor activity in rats bearing human tumor xenografts .
8277370	0	Parathyroid_hormone-related_protein	0,35	PTHrP	37,42	Parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Parathyroid_hormone-related_protein -LRB- PTHrP -RRB- gene expression in solid tumours associated with normocalcaemia and hypercalcaemia .
11280799	0	Parathyroid_hormone-related_protein	0,35	interleukin_8	44,57	Parathyroid hormone-related protein	interleukin 8	5744	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Parathyroid_hormone-related_protein induces interleukin_8 production by prostate_cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence .
22649069	0	Parathyroid_hormone-related_protein	0,35	renin	54,59	Parathyroid hormone-related protein	renin	24695(Tax:10116)	24715(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Parathyroid_hormone-related_protein stimulates plasma renin activity via its anorexic effects on sodium_chloride intake .
18550647	0	Parathyroid_hormone-related_protein	0,35	vascular_endothelial_growth_factor	51,85	Parathyroid hormone-related protein	vascular endothelial growth factor	19227(Tax:10090)	22339(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Parathyroid_hormone-related_protein interacts with vascular_endothelial_growth_factor to promote fibrogenesis in the obstructed mouse kidney .
18651620	0	Parathyroid_hormone-related_protein	0,35	vascular_endothelial_growth_factor	106,140	Parathyroid hormone-related protein	vascular endothelial growth factor	5744	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|activation activation|nmod|receptor-2 receptor-2|compound|END_ENTITY	Parathyroid_hormone-related_protein -LRB- 107-139 -RRB- increases human osteoblastic cell survival by activation of vascular_endothelial_growth_factor receptor-2 .
26995087	0	Park7	41,46	DJ-1	36,40	Park7	DJ-1	11315	11315	Gene	Gene	prevents|nsubj|START_ENTITY END_ENTITY|parataxis|prevents	The Parkinsonism-associated protein DJ-1 / Park7 prevents glycation damage in human keratinocyte .
26021615	0	Park7	0,5	p47	21,24	Park7	p47	57320(Tax:10090)	17304(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Park7 interacts with p47 -LRB- phox -RRB- to direct NADPH oxidase-dependent ROS production and protect against sepsis .
26021615	0	Park7	0,5	p47	21,24	Park7	p47	57320(Tax:10090)	17304(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Park7 interacts with p47 -LRB- phox -RRB- to direct NADPH oxidase-dependent ROS production and protect against sepsis .
17512523	0	Parkin	0,6	LIM_Kinase_1	22,34	Parkin	LIM Kinase 1	5071	3984	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Parkin interacts with LIM_Kinase_1 and reduces its cofilin-phosphorylation activity via ubiquitination .
19358826	0	Parkin	0,6	PINK1	18,23	Parkin	PINK1	5071	65018	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Parkin stabilizes PINK1 through direct interaction .
26992930	0	Parkin	37,43	Parkin	8,14	Parkin	Parkin	40336(Tax:7227)	40336(Tax:7227)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Central Parkin : The evolving role of Parkin in the heart .
26992930	0	Parkin	8,14	Parkin	37,43	Parkin	Parkin	40336(Tax:7227)	40336(Tax:7227)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Central Parkin : The evolving role of Parkin in the heart .
21930938	0	Parkin	0,6	p53	10,13	Parkin	p53	50873(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Parkin , a p53 target gene , mediates the role of p53 in glucose metabolism and the Warburg effect .
22766399	0	Parm1	97,102	prostate_androgen-regulated_mucin-like_protein_1	47,95	Parm1	prostate androgen-regulated mucin-like protein 1	25849	25849	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Murine expression and mutation analyses of the prostate_androgen-regulated_mucin-like_protein_1 -LRB- Parm1 -RRB- gene , a candidate for human epispadias .
16473854	0	Parp-1	31,37	P53	106,109	Parp-1	P53	142	7157	Gene	Gene	polymerase-1|dep|START_ENTITY antagonizes|amod|polymerase-1 topoisomerase|nsubj|antagonizes topoisomerase|nmod|END_ENTITY	Poly -LRB- ADP-RIBOSE -RRB- _ polymerase-1 -LRB- Parp-1 -RRB- antagonizes topoisomerase I-dependent recombination stimulation by P53 .
26712196	0	Part_1	42,48	Insulin	11,18	Part 1	Insulin	25859	3630	Gene	Gene	Misperceptions|dep|START_ENTITY Misperceptions|compound|END_ENTITY	Addressing Insulin Misperceptions -LRB- AIM -RRB- - Part_1 .
20428418	0	Part_1	37,43	insulin	14,21	Part 1	insulin	25859	3630	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	The effect of insulin on the heart : Part_1 : Effects on metabolism and function .
11781568	0	Partner_of_inscuteable	12,34	NuMA	41,45	Partner of inscuteable	NuMA	29899	4926	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	A mammalian Partner_of_inscuteable binds NuMA and regulates mitotic spindle organization .
8109176	0	Pas1p	70,75	Cdc48p	77,83	Pas1p	Cdc48p	853636(Tax:4932)	851431(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	Pas1p	70,75	Sec18p	62,68	Pas1p	Sec18p	853636(Tax:4932)	852372(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	Pas1p	70,75	TBP-1	85,90	Pas1p	TBP-1	853636(Tax:4932)	856891(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
14597576	0	Patched	20,27	Hedgehog	31,39	Patched	Hedgehog	35851(Tax:7227)	42737(Tax:7227)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal , the Drosophila sex determination master switch .
18198278	0	Patched	0,7	Hedgehog	25,33	Patched	Hedgehog	35851(Tax:7227)	42737(Tax:7227)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Patched , the receptor of Hedgehog , is a lipoprotein receptor .
9354432	0	Patched	0,7	smoh	65,69	Patched	smoh	5727	6608	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Patched -LRB- ptch -RRB- - associated preferential expression of smoothened -LRB- smoh -RRB- in human basal_cell_carcinoma_of_the_skin .
15711769	0	Patched-2	51,60	RIZ1	62,66	Patched-2	RIZ1	8643	7799	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Mutational study of the 1p located genes p18ink4c , Patched-2 , RIZ1 and KIF1B in oligodendrogliomas .
15711769	0	Patched-2	51,60	p18ink4c	41,49	Patched-2	p18ink4c	8643	1031	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Mutational study of the 1p located genes p18ink4c , Patched-2 , RIZ1 and KIF1B in oligodendrogliomas .
24073265	0	Patched1	29,37	PTCH1	39,44	Patched1	PTCH1	5727	5727	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variations in Patched1 -LRB- PTCH1 -RRB- gene and risk of hirschsprung_disease in the Han Chinese population .
21177534	0	Patched1	90,98	ZNF431	64,70	Patched1	ZNF431	5727	170959	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription .
11331587	0	Patched1	0,8	cyclin_B1	24,33	Patched1	cyclin B1	5727	891	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Patched1 interacts with cyclin_B1 to regulate cell cycle progression .
24475254	0	Pathogen_and_circadian_controlled_1	0,35	PCC1	37,41	Pathogen and circadian controlled 1	PCC1	821788(Tax:3702)	821788(Tax:3702)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Pathogen_and_circadian_controlled_1 -LRB- PCC1 -RRB- protein is anchored to the plasma membrane and interacts with subunit 5 of COP9 signalosome in Arabidopsis .
19958469	0	Patr-B	24,30	Patr-B	43,49	Patr-B	Patr-B	450202(Tax:9598)	450202(Tax:9598)	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a new Patr-B * 01 variant , Patr-B * 0102 , by sequence-based typing in a chimpanzee -LRB- Pan_troglodytes -RRB- .
19958469	0	Patr-B	43,49	Patr-B	24,30	Patr-B	Patr-B	450202(Tax:9598)	450202(Tax:9598)	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a new Patr-B * 01 variant , Patr-B * 0102 , by sequence-based typing in a chimpanzee -LRB- Pan_troglodytes -RRB- .
17046997	0	Pavarotti-KLP	17,30	Dynactin	0,8	Pavarotti-KLP	Dynactin	38515(Tax:7227)	39536(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|targets targets|compound|END_ENTITY	Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells .
8358169	0	Pax	6,9	Pax-9	16,21	Pax	Pax-9	19303(Tax:10090)	18511(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new Pax gene , Pax-9 , maps to mouse chromosome 12 .
19896935	0	Pax	16,19	eyg	12,15	Pax	eyg	35215(Tax:7227)	39419(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The role of eyg Pax gene in the development of the head vertex in Drosophila .
15153556	0	Pax-2	25,30	Angiotensin_II	0,14	Pax-2	Angiotensin II	18504(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases Pax-2 expression in fetal kidney cells via the AT2_receptor .
15569307	0	Pax-2	26,31	Angiotensin_II	0,14	Pax-2	Angiotensin II	293992(Tax:10116)	24179(Tax:10116)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates Pax-2 in rat kidney proximal tubular cells : impact on proliferation and apoptosis .
9259183	0	Pax-2	62,67	Transforming_growth_factor-beta_1	0,33	Pax-2	Transforming growth factor-beta 1	100347596(Tax:9986)	100008645(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 regulates the expression of Pax-2 , a developmental control gene , in renal tubule cells .
9094722	0	Pax-3	8,13	MyoD	24,28	Pax-3	MyoD	5077	4654	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue .
7909605	0	Pax-3	43,48	splotch	19,26	Pax-3	splotch	5077	18505(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Molecular basis of splotch and Waardenburg Pax-3 mutations .
11845228	0	Pax-4	55,60	Pax-6	103,108	Pax-4	Pax-6	18506(Tax:10090)	18508(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6 .
8664547	0	Pax-5	18,23	BSAP	12,16	Pax-5	BSAP	18507(Tax:10090)	18507(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of BSAP -LRB- Pax-5 -RRB- in B-cell development .
9442394	0	Pax-5	23,28	BSAP	30,34	Pax-5	BSAP	18507(Tax:10090)	18507(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Essential functions of Pax-5 -LRB- BSAP -RRB- in pro-B cell development .
14500810	0	Pax-5	109,114	Ig-alpha	78,86	Pax-5	Ig-alpha	5079	973	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Requirements for selective recruitment of Ets proteins and activation of mb-1 / Ig-alpha gene transcription by Pax-5 -LRB- BSAP -RRB- .
11845228	0	Pax-6	103,108	Pax-4	55,60	Pax-6	Pax-4	18508(Tax:10090)	18506(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6 .
7529875	0	Pax-6	92,97	Pax-QNR	99,106	Pax-6	Pax-QNR	18508(Tax:10090)	18508(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of a neuroretina-specific enhancer element in the quail Pax-6 -LRB- Pax-QNR -RRB- gene .
8246948	0	Pax-6	26,31	Pax-QNR	33,40	Pax-6	Pax-QNR	18508(Tax:10090)	18508(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Characterization of quail Pax-6 -LRB- Pax-QNR -RRB- proteins expressed in the neuroretina .
11222670	0	Pax-6	0,5	SFRP-2	30,36	Pax-6	SFRP-2	18508(Tax:10090)	20319(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS .
10359315	0	Pax-6	0,5	TATA-box-binding_protein	24,48	Pax-6	TATA-box-binding protein	5080	6908	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|protein protein|compound|END_ENTITY	Pax-6 interactions with TATA-box-binding_protein and retinoblastoma protein .
15180990	0	Pax-6	120,125	islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein	27,97	Pax-6	islet-specific glucose-6-phosphatase catalytic subunit-related protein	18508(Tax:10090)	14378(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|gene gene|amod|END_ENTITY	Differential regulation of islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein gene transcription by Pax-6 and Pdx-1 .
9159393	0	Pax-6	36,41	rhodopsin_1	21,32	Pax-6	rhodopsin 1	43833(Tax:7227)	42367(Tax:7227)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Direct regulation of rhodopsin_1 by Pax-6 / eyeless in Drosophila : evidence for a conserved function in photoreceptors .
10198632	0	Pax-6	26,31	twin_of_eyeless	0,15	Pax-6	twin of eyeless	43833(Tax:7227)	43833(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	twin_of_eyeless , a second Pax-6 gene of Drosophila , acts upstream of eyeless in the control of eye development .
7753863	0	Pax-6	0,5	zeta-crystallin	51,66	Pax-6	zeta-crystallin	100727368	100135507(Tax:10141)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|expression expression|nmod|END_ENTITY	Pax-6 is essential for lens-specific expression of zeta-crystallin .
11145590	0	Pax-8	0,5	transforming_growth_factor-beta1	63,95	Pax-8	transforming growth factor-beta1	81819(Tax:10116)	59086(Tax:10116)	Gene	Gene	essential|nsubj|START_ENTITY essential|advcl|END_ENTITY	Pax-8 is essential for regulation of the thyroglobulin gene by transforming_growth_factor-beta1 .
8358169	0	Pax-9	16,21	Pax	6,9	Pax-9	Pax	18511(Tax:10090)	19303(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new Pax gene , Pax-9 , maps to mouse chromosome 12 .
7529875	0	Pax-QNR	99,106	Pax-6	92,97	Pax-QNR	Pax-6	18508(Tax:10090)	18508(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and characterization of a neuroretina-specific enhancer element in the quail Pax-6 -LRB- Pax-QNR -RRB- gene .
8246948	0	Pax-QNR	33,40	Pax-6	26,31	Pax-QNR	Pax-6	18508(Tax:10090)	18508(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Characterization of quail Pax-6 -LRB- Pax-QNR -RRB- proteins expressed in the neuroretina .
12490554	0	Pax1	0,4	Bapx1	23,28	Pax1	Bapx1	18503(Tax:10090)	12020(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome .
7649395	0	Pax1	95,99	Pax9	49,53	Pax1	Pax9	18503(Tax:10090)	18511(Tax:10090)	Gene	Gene	related|nmod|START_ENTITY related|nsubj|expression expression|nmod|END_ENTITY	Characterization and developmental expression of Pax9 , a paired-box-containing gene related to Pax1 .
19505455	0	Pax2	22,26	BMP7	0,4	Pax2	BMP7	18504(Tax:10090)	12162(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression .
22438572	0	Pax2	45,49	Hox	28,31	Pax2	Hox	43825(Tax:7227)	42536(Tax:7227)	Gene	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	Integration of an abdominal Hox complex with Pax2 yields cell-specific EGF secretion from Drosophila sensory precursor cells .
20943750	0	Pax2	30,34	Opdc	4,8	Pax2	Opdc	5076	18504(Tax:10090)	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	The Opdc missense mutation of Pax2 has a milder than loss-of-function phenotype .
10330495	0	Pax2	36,40	Otx2	24,28	Pax2	Otx2	395574(Tax:9031)	395191(Tax:9031)	Gene	Gene	Fgf8|dep|START_ENTITY Fgf8|compound|END_ENTITY	Comparative analysis of Otx2 , Gbx2 , Pax2 , Fgf8 and Wnt1 gene expressions during the formation of the chick midbrain/hindbrain domain .
10908331	0	Pax2	60,64	PTIP	0,4	Pax2	PTIP	5076	22976	Gene	Gene	BRCT|nmod|START_ENTITY BRCT|advmod|END_ENTITY	PTIP , a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin .
19124460	0	Pax2	16,20	PTIP	65,69	Pax2	PTIP	5076	22976	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Accumulation of Pax2 transactivation domain interaction protein -LRB- PTIP -RRB- at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage .
25631048	0	Pax2	140,144	PTIP	99,103	Pax2	PTIP	5076	22976	Gene	Gene	Switch|dobj|START_ENTITY Displaces|xcomp|Switch Displaces|dobj|Pax_Transactivation_Domain_Interacting_Protein Pax_Transactivation_Domain_Interacting_Protein|appos|END_ENTITY	The Groucho-associated Phosphatase PPM1B Displaces Pax_Transactivation_Domain_Interacting_Protein -LRB- PTIP -RRB- to Switch the Transcription Factor Pax2 from a Transcriptional Activator to a Repressor .
15013809	0	Pax2	14,18	YY1	64,67	Pax2	YY1	18504(Tax:10090)	22632(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of Pax2 in the intermediate mesoderm is regulated by YY1 .
21525034	0	Pax3	36,40	Emerin	0,6	Pax3	Emerin	5077	2010	Gene	Gene	binding|nmod|START_ENTITY inhibits|xcomp|binding inhibits|nsubj|END_ENTITY	Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes .
24036067	0	Pax3	0,4	Gli2	21,25	Pax3	Gli2	5077	2736	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer .
9731536	0	Pax3	102,106	HIRA	0,4	Pax3	HIRA	18505(Tax:10090)	7290	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HIRA , a mammalian homologue of Saccharomyces_cerevisiae transcriptional co-repressors , interacts with Pax3 .
18308300	0	Pax3	85,89	Hes1	54,58	Pax3	Hes1	18505(Tax:10090)	15205(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Key basic helix-loop-helix transcription factor genes Hes1 and Ngn2 are regulated by Pax3 during mouse embryonic development .
21169561	0	Pax3	8,12	Hes1	46,50	Pax3	Hes1	18505(Tax:10090)	15205(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY acetylation|nsubj|Role acetylation|nmod|regulation regulation|nmod|END_ENTITY	Role of Pax3 acetylation in the regulation of Hes1 and Neurog2 .
21525034	0	Pax3	36,40	Lmo7	16,20	Pax3	Lmo7	5077	4008	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes .
21749861	0	Pax3	17,21	Pax7	23,27	Pax3	Pax7	5077	5081	Gene	Gene	+|compound|START_ENTITY +|parataxis|+ +|nsubj|END_ENTITY	Pitx2c modulates Pax3 + / Pax7 + cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis .
11032856	0	Pax3	0,4	Sox10	66,71	Pax3	Sox10	5077	6663	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret .
16787918	0	Pax3	33,37	TGFbeta2	21,29	Pax3	TGFbeta2	18505(Tax:10090)	21808(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of murine TGFbeta2 by Pax3 during early embryonic development .
18644785	0	Pax3	58,62	Tbx18	14,19	Pax3	Tbx18	18505(Tax:10090)	76365(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm .
14736747	0	Pax3	134,138	Tead2	110,115	Pax3	Tead2	18505(Tax:10090)	21677(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3 .
14736747	0	Pax3	59,63	Tead2	110,115	Pax3	Tead2	18505(Tax:10090)	21677(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3 .
18086577	0	Pax3	0,4	Wnt1	15,19	Pax3	Wnt1	5077	7471	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Pax3 regulates Wnt1 expression via a conserved binding site in the 5 ' proximal promoter .
11830592	0	Pax3	0,4	interleukin-6	76,89	Pax3	interleukin-6	18505(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Pax3 down-regulation and shut-off of melanogenesis in melanoma B16/F10 .9 by interleukin-6 receptor signaling .
9463628	0	Pax3	64,68	splotch	55,62	Pax3	splotch	18505(Tax:10090)	18505(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Development of a lethal congenital_heart_defect in the splotch -LRB- Pax3 -RRB- mutant mouse .
18058910	0	Pax4	29,33	Ghrelin	0,7	Pax4	Ghrelin	18506(Tax:10090)	58991(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum .
19616560	0	Pax5	73,77	Ets-1	34,39	Pax5	Ets-1	5079	2113	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5 .
16482219	0	Pax5	66,70	c-fms	52,57	Pax5	c-fms	5079	1436	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction .
21357426	0	Pax5	42,46	p300	26,30	Pax5	p300	5079	2033	Gene	Gene	acetylates|dobj|START_ENTITY acetylates|nsubj|END_ENTITY	Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity .
17122106	0	Pax6	0,4	CCCTC_binding_factor	36,56	Pax6	CCCTC binding factor	18508(Tax:10090)	13018(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Pax6 regulation in retinal cells by CCCTC_binding_factor .
21996446	0	Pax6	102,106	Cellular_retinaldehyde-binding_protein	0,38	Pax6	Cellular retinaldehyde-binding protein	5080	6017	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cellular_retinaldehyde-binding_protein -LRB- CRALBP -RRB- is a direct downstream target of transcription factor Pax6 .
15254898	0	Pax6	0,4	Clock	68,73	Pax6	Clock	5080	9575	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Pax6 is a direct , positively regulated target of the circadian gene Clock .
22308399	0	Pax6	57,61	Dachshund	23,32	Pax6	Dachshund	43833(Tax:7227)	34982(Tax:7227)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression .
25029272	0	Pax6	0,4	Dkk3	33,37	Pax6	Dkk3	18508(Tax:10090)	50781(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Pax6 regulates the expression of Dkk3 in murine and human cell lines , and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6 -LRB- 5a -RRB- isoform .
18307776	0	Pax6	31,35	Er81	0,4	Pax6	Er81	5080	2115	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Er81 is a downstream target of Pax6 in cortical progenitors .
14673159	0	Pax6	22,26	Gelatinase_B	144,156	Pax6	Gelatinase B	18508(Tax:10090)	17395(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Expression Expression|nmod|END_ENTITY	Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase_B .
26226504	0	Pax6	45,49	Kruppel-Like_Factor_4	0,21	Pax6	Kruppel-Like Factor 4	18508(Tax:10090)	16600(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	Kruppel-Like_Factor_4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development .
12128206	0	Pax6	30,34	L-Maf	0,5	Pax6	L-Maf	395943(Tax:9031)	395881(Tax:9031)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	L-Maf , a downstream target of Pax6 , is essential for chick lens development .
19208436	0	Pax6	0,4	Math5	19,24	Pax6	Math5	18508(Tax:10090)	53404(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Pax6 regulation of Math5 during mouse retinal neurogenesis .
25352170	0	Pax6	0,4	Odf2	67,71	Pax6	Odf2	5080	4957	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Pax6 controls centriole maturation in cortical progenitors through Odf2 .
19223471	0	Pax6	0,4	PC2	49,52	Pax6	PC2	5080	5126	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2 .
23056534	0	Pax6	0,4	Pcsk1n	29,35	Pax6	Pcsk1n	18508(Tax:10090)	30052(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing .
22539874	0	Pax6	0,4	SPARC	20,25	Pax6	SPARC	18508(Tax:10090)	20692(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pax6 interacts with SPARC and TGF-b in murine eyes .
18287938	0	Pax6	0,4	Sox2	23,27	Pax6	Sox2	18508(Tax:10090)	20674(Tax:10090)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|expression expression|amod|END_ENTITY	Pax6 directly modulate Sox2 expression in the neural progenitor cells .
11222774	0	Pax6	39,43	c-maf	14,19	Pax6	c-maf	25509(Tax:10116)	54267(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of c-maf gene expression by Pax6 in cultured cells .
19116343	0	Pax6	0,4	glucagon-like_peptide_1	81,104	Pax6	glucagon-like peptide 1	18508(Tax:10090)	14526(Tax:10090)	Gene	Gene	causes|nsubj|START_ENTITY causes|nmod|END_ENTITY	Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating glucagon-like_peptide_1 in mice .
16407227	0	Pax6	39,43	homeodomain-interacting_protein_kinase_2	47,87	Pax6	homeodomain-interacting protein kinase 2	5080	28996	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and transactivation of Pax6 by homeodomain-interacting_protein_kinase_2 .
23516376	0	Pax6	0,4	miR-204	62,69	Pax6	miR-204	18508(Tax:10090)	387200(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Pax6 regulates gene expression in the vertebrate lens through miR-204 .
22863532	0	Pax7	16,20	Carm1	0,5	Pax7	Carm1	5081	10498	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions .
26372956	0	Pax7	22,26	Caspase_3	0,9	Pax7	Caspase 3	5081	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Caspase_3 cleavage of Pax7 inhibits self-renewal of satellite cells .
19458195	0	Pax7	42,46	Id3	0,3	Pax7	Id3	18509(Tax:10090)	15903(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells .
17949710	0	Pax7	26,30	Myostatin	0,9	Pax7	Myostatin	18509(Tax:10090)	17700(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Myostatin signals through Pax7 to regulate satellite cell self-renewal .
21749861	0	Pax7	23,27	Pax3	17,21	Pax7	Pax3	5081	5077	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	Pitx2c modulates Pax3 + / Pax7 + cell populations and regulates Pax3 expression by repressing miR27 expression during myogenesis .
23942518	0	Pax7	0,4	cMyb	21,25	Pax7	cMyb	395942(Tax:9031)	396244(Tax:9031)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Pax7 is regulated by cMyb during early neural crest development through a novel enhancer .
14531730	0	Pax8	93,97	WBP-2	0,5	Pax8	WBP-2	7849	23558	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	WBP-2 , a WW domain binding protein , interacts with the thyroid-specific transcription factor Pax8 .
25270402	0	Pax8	0,4	Wnt4	33,37	Pax8	Wnt4	81819(Tax:10116)	84426(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells .
9671580	0	Pax8	97,101	noi	128,131	Pax8	noi	60637(Tax:7955)	60636(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Characterization of three novel members of the zebrafish Pax2/5/8 family : dependency of Pax5 and Pax8 expression on the Pax2 .1 -LRB- noi -RRB- function .
21420399	0	Pax9	24,28	Osr2	0,4	Pax9	Osr2	18511(Tax:10090)	107587(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field .
7649395	0	Pax9	49,53	Pax1	95,99	Pax9	Pax1	18511(Tax:10090)	18503(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY related|nsubj|expression related|nmod|END_ENTITY	Characterization and developmental expression of Pax9 , a paired-box-containing gene related to Pax1 .
12617855	0	Pax_2	0,5	EphA4	70,75	Pax 2	EphA4	395574(Tax:9031)	395559(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Pax_2 expression in mesodermal segmentation and its relationship with EphA4 and Lunatic-fringe during chicken somitogenesis .
14516678	0	Pax_2	0,5	EphA4	70,75	Pax 2	EphA4	395574(Tax:9031)	395559(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Pax_2 expression in mesodermal segmentation and its relationship with EphA4 and Lunatic-fringe during chicken somitogenesis .
10924503	0	Pax_8	17,22	thyroperoxidase	36,51	Pax 8	thyroperoxidase	7849	7173	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Role for p300 in Pax_8 induction of thyroperoxidase gene expression .
25070956	0	Paxillin	0,8	HDAC6	18,23	Paxillin	HDAC6	5829	10013	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Paxillin inhibits HDAC6 to regulate microtubule acetylation , Golgi structure , and polarized migration .
9162070	0	Paxillin	0,8	calcium-dependent_tyrosine_kinase	78,111	Paxillin	calcium-dependent tyrosine kinase	360820(Tax:10116)	50646(Tax:10116)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent_tyrosine_kinase in rat liver epithelial cells .
12118253	0	Paxillin	0,8	schwannomin	15,26	Paxillin	schwannomin	5829	4771	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology .
22629471	0	Paxillin	0,8	vinculin	36,44	Paxillin	vinculin	5829	7414	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA .
23615439	0	Paxillin_kinase_linker	0,22	Vav2	39,43	Paxillin kinase linker	Vav2	5313	7410	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Paxillin_kinase_linker -LRB- PKL -RRB- regulates Vav2 signaling during cell spreading and migration .
19607825	0	Pbx	0,3	Hand2	14,19	Pbx	Hand2	170445(Tax:7955)	58150(Tax:7955)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Pbx acts with Hand2 in early myocardial_differentiation .
24591256	0	Pbx1	0,4	Fgf10	15,20	Pbx1	Fgf10	5087	2255	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Pbx1 activates Fgf10 in the mesenchyme of developing lungs .
18093541	0	Pbx1	116,120	Interleukin-10	0,14	Pbx1	Interleukin-10	5087	3586	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1 .
16637071	0	Pbx1	15,19	PLZF	0,4	Pbx1	PLZF	5087	7704	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	PLZF regulates Pbx1 transcription and Pbx1-HoxC8 complex leads to androgen-independent prostate_cancer proliferation .
11262231	0	Pbx4	22,26	Meis3	0,5	Pbx4	Meis3	30728(Tax:7955)	81885(Tax:7955)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish .
19666537	0	PcG	72,75	Polycomb_group	56,70	PcG	Polycomb group	40358(Tax:7227)	40358(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Drosophila O-GlcNAc transferase -LRB- OGT -RRB- is encoded by the Polycomb_group -LRB- PcG -RRB- gene , super sex combs -LRB- sxc -RRB- .
12628927	0	PcG	40,43	YY1	21,24	PcG	YY1	40358(Tax:7227)	43819(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Transcription factor YY1 functions as a PcG protein in vivo .
16052488	0	PcG	45,48	YY1	26,29	PcG	YY1	40358(Tax:7227)	43819(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Transient requirements of YY1 expression for PcG transcriptional repression and phenotypic rescue .
19960508	0	PcG	0,3	YY1	23,26	PcG	YY1	40358(Tax:7227)	43819(Tax:7227)	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|domain domain|compound|END_ENTITY	PcG recruitment by the YY1 REPO domain can be mediated by Yaf2 .
22174740	0	PcG	49,52	dHCF	24,28	PcG	dHCF	40358(Tax:7227)	43788(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Drosophila_melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators .
18729229	0	Pcdh1	31,36	protocadherin-1	14,29	Pcdh1	protocadherin-1	75599(Tax:10090)	75599(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of protocadherin-1 -LRB- Pcdh1 -RRB- during mouse development .
19151506	0	Pcdh15	115,121	protocadherin_15	97,113	Pcdh15	protocadherin 15	690865(Tax:10116)	690865(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the Kyoto circling -LRB- KCI -RRB- rat carrying a spontaneous nonsense mutation in the protocadherin_15 -LRB- Pcdh15 -RRB- gene .
18298670	0	Pcf11p	63,69	PCFS4	12,17	Pcf11p	PCFS4	851814(Tax:4932)	825827(Tax:3702)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Arabidopsis PCFS4 , a homologue of yeast polyadenylation factor Pcf11p , regulates FCA alternative processing and promotes flowering time .
22072981	0	Pch2	0,4	Xrs2	18,22	Pch2	Xrs2	852484(Tax:4932)	851975(Tax:4932)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosis .
20870947	0	Pcid2	17,22	MAD2	68,72	Pcid2	MAD2	234069(Tax:10090)	56150(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression .
10490639	0	Pcl10p	78,84	Pho85p	57,63	Pcl10p	Pho85p	852743(Tax:4932)	856076(Tax:4932)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10p .
23671666	0	Pcp4	51,55	Hoxa2	96,101	Pcp4	Hoxa2	18546(Tax:10090)	15399(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY regulated|nsubjpass|distribution regulated|nmod|END_ENTITY	Differential distribution of the Ca -LRB- 2 + -RRB- regulator Pcp4 in the branchial arches is regulated by Hoxa2 .
23056534	0	Pcsk1n	29,35	Pax6	0,4	Pcsk1n	Pax6	30052(Tax:10090)	18508(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing .
12084709	0	Pctaire1	0,8	p35	24,27	Pctaire1	p35	18555(Tax:10090)	12569(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35 .
14634209	0	Pctr2	101,106	Frap	0,4	Pctr2	Frap	104290(Tax:10090)	56717(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Frap , FKBP12_rapamycin-associated_protein , is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene .
22393466	0	Pdcd4	18,23	Cyclin_D1	47,56	Pdcd4	Cyclin D1	27250	595	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin_D1 Expression and Promotes Cell Proliferation .
23536002	0	Pdcd4	25,30	Daxx	46,50	Pdcd4	Daxx	27250	1616	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tumor_suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46 .
22801218	0	Pdcd4	0,5	MAP4K1	29,35	Pdcd4	MAP4K1	27250	11184	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc .
17968323	0	Pdcd4	75,80	MicroRNA-21	0,11	Pdcd4	MicroRNA-21	27250	406991	Gene	Gene	tumor|dobj|START_ENTITY tumor|nsubj|downregulates downregulates|amod|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion , intravasation and metastasis in colorectal_cancer .
23049623	0	Pdcd4	25,30	Programmed_cell_death_4	0,23	Pdcd4	Programmed cell death 4	27250	27250	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Programmed_cell_death_4 -LRB- Pdcd4 -RRB- expression in colorectal_adenocarcinoma : Association with clinical stage .
25820028	0	Pdcd4	33,38	Programmed_cell_death_4	0,23	Pdcd4	Programmed cell death 4	27250	27250	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Programmed_cell_death_4 protein -LRB- Pdcd4 -RRB- and homeodomain-interacting_protein_kinase_2 -LRB- Hipk2 -RRB- antagonistically control translation of Hipk2 mRNA .
15334056	0	Pdcd4	34,39	c-Jun	137,142	Pdcd4	c-Jun	27250	3725	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun .
20498644	0	Pdcd4	0,5	lysyl_oxidase	20,33	Pdcd4	lysyl oxidase	27250	4015	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	Pdcd4 repression of lysyl_oxidase inhibits hypoxia-induced breast_cancer cell invasion .
17968323	0	Pdcd4	75,80	miR-21	13,19	Pdcd4	miR-21	27250	406991	Gene	Gene	tumor|dobj|START_ENTITY tumor|nsubj|downregulates downregulates|dep|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion , intravasation and metastasis in colorectal_cancer .
23469214	0	Pdcd4	45,50	miR-21	24,30	Pdcd4	miR-21	27250	406991	Gene	Gene	regulations|nmod|START_ENTITY regulations|nmod|END_ENTITY	Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation .
23578931	0	Pdcd4	17,22	miR-21	0,6	Pdcd4	miR-21	27250	406991	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	miR-21 represses Pdcd4 during cardiac valvulogenesis .
25979949	0	Pdcd4	98,103	miR-21	65,71	Pdcd4	miR-21	18569(Tax:10090)	387140(Tax:10090)	Gene	Gene	repression|compound|START_ENTITY repression|amod|mediated mediated|amod|END_ENTITY	Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression .
25979949	0	Pdcd4	98,103	miR-21	65,71	Pdcd4	miR-21	18569(Tax:10090)	387140(Tax:10090)	Gene	Gene	repression|compound|START_ENTITY repression|amod|mediated mediated|amod|END_ENTITY	Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression .
16449643	0	Pdcd4	25,30	mitogen-activated_protein_kinase_kinase_kinase_kinase_1	46,101	Pdcd4	mitogen-activated protein kinase kinase kinase kinase 1	27250	11184	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated_protein_kinase_kinase_kinase_kinase_1 expression to suppress colon_carcinoma cell invasion .
25573956	0	Pdcd4	36,41	p70S6K1	14,21	Pdcd4	p70S6K1	18569(Tax:10090)	72508(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R / IR Inhibitor in Colon_Carcinoma Cells .
20238051	0	Pde6b	63,68	rd1	71,74	Pde6b	rd1	18587(Tax:10090)	18587(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Do calcium channel blockers rescue dying photoreceptors in the Pde6b -LRB- rd1 -RRB- mouse ?
11708858	0	Pdha1	51,56	pyruvate_dehydrogenase	27,49	Pdha1	pyruvate dehydrogenase	18597(Tax:10090)	18597(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inactivation of the murine pyruvate_dehydrogenase -LRB- Pdha1 -RRB- gene and its effect on early embryonic development .
19895804	0	Pdlim7	0,6	Tbx5	28,32	Pdlim7	Tbx5	393813(Tax:7955)	30071(Tax:7955)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Pdlim7 -LRB- LMP4 -RRB- regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation .
20133786	0	Pdp1epsilon	50,61	takeout	26,33	Pdp1epsilon	takeout	45588(Tax:7227)	43036(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The circadian output gene takeout is regulated by Pdp1epsilon .
9428726	0	Pdr1	93,97	PDR10	51,56	Pdr1	PDR10	852871(Tax:4932)	854506(Tax:4932)	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	The yeast ATP binding cassette -LRB- ABC -RRB- protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators .
15294907	0	Pdr1	33,37	PDR5	57,61	Pdr1	PDR5	852871(Tax:4932)	854324(Tax:4932)	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces_cerevisiae : evidence for enhanced recruitment of coactivators and altered nucleosome structures .
10647015	0	Pds1	75,79	Cdc20	4,9	Pds1	Cdc20	851691(Tax:4932)	852762(Tax:4932)	Gene	Gene	destroying|dobj|START_ENTITY promotes|advcl|destroying promotes|nsubj|APC APC|appos|END_ENTITY	APC -LRB- Cdc20 -RRB- promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5 .
11553328	0	Pds1	23,27	Cdc20	66,71	Pds1	Cdc20	851691(Tax:4932)	852762(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner .
9501986	0	Pds1	66,70	Cdc20	0,5	Pds1	Cdc20	851691(Tax:4932)	852762(Tax:4932)	Gene	Gene	proteolysis|nmod|START_ENTITY essential|nmod|proteolysis essential|nsubj|END_ENTITY	Cdc20 is essential for the cyclosome-mediated proteolysis of both Pds1 and Clb2 during M phase in budding yeast .
11433293	0	Pds1p	16,21	Mec1p	0,5	Pds1p	Mec1p	7986	545	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Mec1p regulates Pds1p levels in S phase : complex coordination of DNA replication and mitosis .
26923598	0	Pds5	44,48	Scc1	77,81	Pds5	Scc1	855099(Tax:4932)	851561(Tax:4932)	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1 .
20942803	0	Pdx-1	58,63	Slc30a8	74,81	Pdx-1	Slc30a8	18609(Tax:10090)	239436(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	The pancreatic islet b-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer .
10393088	0	Pdx-1	38,43	Upstream_stimulatory_factor	0,27	Pdx-1	Upstream stimulatory factor	3651	7391	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Upstream_stimulatory_factor regulates Pdx-1 gene expression in differentiated pancreatic beta-cells .
15144884	0	Pdx-1	0,5	insulin	14,21	Pdx-1	insulin	3651	3630	Gene	Gene	enables|nsubj|START_ENTITY enables|dobj|secretion secretion|compound|END_ENTITY	Pdx-1 enables insulin secretion by regulating synaptotagmin_1 gene expression .
15166251	0	Pdx-1	126,131	insulin	22,29	Pdx-1	insulin	3651	3630	Gene	Gene	requires|nmod|START_ENTITY requires|nsubj|regulation regulation|nmod|expression expression|compound|END_ENTITY	Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1 .
15743769	0	Pdx-1	76,81	insulin	13,20	Pdx-1	insulin	3651	3630	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1 : application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes .
15756539	0	Pdx-1	15,20	insulin	53,60	Pdx-1	insulin	3651	3630	Gene	Gene	Suppression|nmod|START_ENTITY perturbs|nsubj|Suppression perturbs|dobj|processing processing|appos|secretion secretion|compound|END_ENTITY	Suppression of Pdx-1 perturbs proinsulin processing , insulin secretion and GLP-1 signalling in INS-1 cells .
16141209	0	Pdx-1	0,5	insulin	94,101	Pdx-1	insulin	3651	3630	Gene	Gene	links|amod|START_ENTITY histone|nsubj|links histone|nmod|II II|acl|elongation elongation|nmod|activation activation|nmod|transcription transcription|compound|END_ENTITY	Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription .
17451835	0	Pdx-1	5,10	insulin	66,73	Pdx-1	insulin	3651	3630	Gene	Gene	requisite|nsubj|START_ENTITY requisite|nmod|maintenance maintenance|nmod|expression expression|compound|END_ENTITY	Both Pdx-1 and NeuroD1 genes are requisite for the maintenance of insulin gene expression in ES-derived differentiated cells .
17158802	0	Pdx1	43,47	Insulin	0,7	Pdx1	Insulin	3651	3630	Gene	Gene	apoptosis|nmod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome .
24032047	0	Pdx1	41,45	Leptin	15,21	Pdx1	Leptin	29535(Tax:10116)	25608(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of Leptin and Adiponectin on Pdx1 , Foxm1 , and PPARy Transcription in Rat Islets of Langerhans .
18522939	0	Pdx1	23,27	MafA	0,4	Pdx1	MafA	18609(Tax:10090)	378435(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	MafA and MafB regulate Pdx1 transcription through the Area II control region in pancreatic beta cells .
22776709	0	Pdx1	27,31	Ngn3	53,57	Pdx1	Ngn3	18609(Tax:10090)	11925(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The combined expression of Pdx1 and MafA with either Ngn3 or NeuroD improves the differentiation efficiency of mouse embryonic stem cells into insulin-producing cells .
21294959	0	Pdx1	0,4	PLAG1	28,33	Pdx1	PLAG1	18609(Tax:10090)	56711(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Pdx1 - and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads_to_endocrine_hormone_imbalances that affect glucose metabolism .
10657497	0	Pdyn	76,80	preprodynorphin	59,74	Pdyn	preprodynorphin	18610(Tax:10090)	18610(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the mouse homolog of the preprodynorphin -LRB- Pdyn -RRB- gene .
3593832	0	Ped	51,54	preimplantation-embryo-development	15,49	Ped	preimplantation-embryo-development	110340(Tax:10090)	110340(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Linkage of the preimplantation-embryo-development -LRB- Ped -RRB- gene to the mouse major histocompatibility complex -LRB- MHC -RRB- .
24582979	0	Peg3	21,25	APeg3	0,5	Peg3	APeg3	5178	100169890	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	APeg3 : regulation of Peg3 through an evolutionarily conserved ncRNA .
17071620	0	Peg3	23,27	Cyclophilin_a	0,13	Peg3	Cyclophilin a	18616(Tax:10090)	268373(Tax:10090)	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Cyclophilin_a protects Peg3 from hypermethylation and inactive histone modification .
18166131	0	Peg3	35,39	MacroH2A1	0,9	Peg3	MacroH2A1	18616(Tax:10090)	26914(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	MacroH2A1 knockdown effects on the Peg3 imprinted domain .
25774914	0	Peg3	52,56	Yy1	0,3	Peg3	Yy1	18616(Tax:10090)	22632(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|compound|END_ENTITY	Yy1 Gene Dosage Effect and Bi-Allelic Expression of Peg3 .
11045567	0	Peg3	19,23	tumor_necrosis_factor_alpha	45,72	Peg3	tumor necrosis factor alpha	18616(Tax:10090)	21926(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	The imprinted gene Peg3 is not essential for tumor_necrosis_factor_alpha signaling .
11731453	0	Pelle	19,24	Toll	72,76	Pelle	Toll	43283(Tax:7227)	43222(Tax:7227)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway .
11934858	0	Pelle	0,5	Toll	56,60	Pelle	Toll	43283(Tax:7227)	43222(Tax:7227)	Gene	Gene	kinase|amod|START_ENTITY activated|nsubjpass|kinase activated|nmod|END_ENTITY	Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila .
12860405	0	Pellino2	20,28	IRAK1	45,50	Pellino2	IRAK1	57161	3654	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Pellino2 , a substrate of IRAK1 and IRAK4 .
24113711	0	Pellino3	0,8	RIP1	17,21	Pellino3	RIP1	240518(Tax:10090)	19766(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-a .
12438745	0	Pelo	19,23	pelota	6,12	Pelo	pelota	105083(Tax:10090)	34286(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mouse pelota gene -LRB- Pelo -RRB- : cDNA cloning , genomic structure , and chromosomal localization .
20406461	0	Pelota	0,6	HAX1	22,26	Pelota	HAX1	53918	10456	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pelota interacts with HAX1 , EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton .
20559002	0	Pen	0,3	CD44	42,46	Pen	CD44	340348	960	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Pen ch_13 major fungal allergen decreases CD44 expression in human bronchial epithelial cells .
24969115	0	Pen	25,28	Insulin	17,24	Pen	Insulin	340348	3630	Gene	Gene	Errors|compound|START_ENTITY Errors|compound|END_ENTITY	A New `` Twist '' on Insulin Pen Administrat ion Errors .
25662503	0	Pen	59,62	Insulin	23,30	Pen	Insulin	340348	3630	Gene	Gene	Needle|compound|START_ENTITY Delivered|nmod|Needle Delivered|compound|END_ENTITY	Safety and Efficacy of Insulin Therapy Delivered via a 4mm Pen Needle in Obese Patients With Diabetes .
25673892	0	Pen	35,38	Insulin	71,78	Pen	Insulin	340348	3630	Gene	Gene	Vial|amod|START_ENTITY Converting|nmod|Vial Impact|acl|Converting Impact|nmod|Delivery Delivery|compound|END_ENTITY	Economic Impact of Converting from Pen and 10-mL Vial to 3-mL Vial for Insulin Delivery in a Hospital Setting .
26085903	0	Pen	21,24	Insulin	13,20	Pen	Insulin	340348	3630	Gene	Gene	Therapy|compound|START_ENTITY Therapy|compound|END_ENTITY	Adherence to Insulin Pen Therapy Is Associated with Reduction in Healthcare Costs Among Patients with Type_2_Diabetes_Mellitus .
2115686	1	Pen	196,199	insulin	158,165	Pen	insulin	340348	3630	Gene	Gene	-RSB-|compound|START_ENTITY using|dobj|-RSB- administration|acl|using administration|compound|END_ENTITY	Randomized study between evening and morning intermediary insulin administration using the Novo Pen semi-automatic insulin injector -RSB- .
2115686	1	Pen	196,199	insulin	215,222	Pen	insulin	340348	3630	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Randomized study between evening and morning intermediary insulin administration using the Novo Pen semi-automatic insulin injector -RSB- .
25394380	0	Pen2	39,43	Presenilin-1	18,30	Pen2	Presenilin-1	55851	5663	Gene	Gene	Interaction|compound|START_ENTITY END_ENTITY|dep|Interaction	G206D Mutation of Presenilin-1 Reduces Pen2 Interaction , Increases Ab42/Ab40 Ratio and Elevates ER Ca -LRB- 2 + -RRB- Accumulation .
26644796	0	Pentraxin3	17,27	TNF	0,3	Pentraxin3	TNF	5806	7124	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways .
26027989	0	Pentraxin_3	23,34	C-reactive_Protein	123,141	Pentraxin 3	C-reactive Protein	5806	1401	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Elevated Expression of Pentraxin_3 in Anti-neutrophil Cytoplasmic Antibody-associated Glomerulonephritis with Normal Serum C-reactive_Protein .
25855355	0	Pentraxin_3	42,53	Factor_H-Related_Protein_5	0,26	Pentraxin 3	Factor H-Related Protein 5	5806	81494	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	Factor_H-Related_Protein_5 Interacts with Pentraxin_3 and the Extracellular Matrix and Modulates Complement Activation .
22529962	0	Pentraxin_3	0,11	PTX3	13,17	Pentraxin 3	PTX3	5806	5806	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pentraxin_3 -LRB- PTX3 -RRB- expression in allergic_asthmatic airways : role in airway smooth muscle migration and chemokine production .
20179141	0	Pep1	35,39	PEPR2	0,5	Pep1	PEPR2	836613(Tax:3702)	838353(Tax:3702)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	PEPR2 is a second receptor for the Pep1 and Pep2 peptides and contributes to defense responses in Arabidopsis .
8730101	0	Pep12p	26,32	syntaxin	6,14	Pep12p	syntaxin	854201(Tax:4932)	851219(Tax:4932)	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Novel syntaxin homologue , Pep12p , required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast .
21311026	0	PepT1	147,152	cholecystokinin	28,43	PepT1	cholecystokinin	117261(Tax:10116)	25298(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|secretion secretion|compound|END_ENTITY	Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1 .
23234698	0	PepT1	56,61	peptide_transporter_1	33,54	PepT1	peptide transporter 1	397624(Tax:9823)	397624(Tax:9823)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ontogeny of dipeptide uptake and peptide_transporter_1 -LRB- PepT1 -RRB- expression along the gastrointestinal tract in the neonatal Yucatan miniature pig .
18256027	0	Pepsinogen_C	0,12	surfactant_protein_B	39,59	Pepsinogen C	surfactant protein B	5225	6439	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Pepsinogen_C proteolytic processing of surfactant_protein_B .
20375207	0	Peptide_YY	0,10	growth_hormone	63,77	Peptide YY	growth hormone	5697	2688	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Peptide_YY levels across pubertal stages and associations with growth_hormone .
8616536	0	Peptide_YY	0,10	insulin	47,54	Peptide YY	insulin	5697	3630	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Peptide_YY does not inhibit glucose-stimulated insulin secretion in humans .
3671783	0	Peptide_YY	0,10	secretin	26,34	Peptide YY	secretin	607156(Tax:9615)	483407(Tax:9615)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Peptide_YY interacts with secretin and duodenal acidification to inhibit gastric_acid secretion .
17854384	0	Peptide_transporter_2	0,21	PEPT2	23,28	Peptide transporter 2	PEPT2	57738(Tax:10090)	57738(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Peptide_transporter_2 -LRB- PEPT2 -RRB- expression in brain protects against 5-aminolevulinic_acid neurotoxicity .
18035491	0	Peptidoglycan_recognition_protein-S	0,35	NF-kappaB	63,72	Peptidoglycan recognition protein-S	NF-kappaB	21946(Tax:10090)	18033(Tax:10090)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Peptidoglycan_recognition_protein-S -LRB- PGRP-S -RRB- is upregulated by NF-kappaB .
8187161	0	Peptidylglycine_alpha-amidating_monooxygenase	0,45	PAM	47,50	Peptidylglycine alpha-amidating monooxygenase	PAM	5066	5066	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- immunoreactivity and messenger RNA in human pituitary and increased expression in pituitary_tumours .
26377793	0	Per1	76,80	NHE3	30,34	Per1	NHE3	18626(Tax:10090)	105243(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of NHE3 and SGLT1 by the Circadian Clock Protein Per1 in Proximal Tubule Cells .
18400210	0	Per1	47,51	SCN	79,82	Per1	SCN	287422(Tax:10116)	24766(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of 5-HT2C receptors acutely induces Per1 gene expression in the rat SCN in vitro .
26850841	0	Per1	42,46	c-MYC	0,5	Per1	c-MYC	5187	4609	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	c-MYC targets the central oscillator gene Per1 and is regulated by the circadian clock at the post-transcriptional level .
17364588	0	Per1	76,80	clock	64,69	Per1	clock	5187	9575	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Treatment with beta2-adrenoceptor agonist in vivo induces human clock gene , Per1 , mRNA expression in peripheral blood .
15917222	0	Per1	121,125	period-1	111,119	Per1	period-1	5187	5187	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 -LRB- Per1 -RRB- protein .
19926610	0	Per2	0,4	C/EBP	10,15	Per2	C/EBP	8864	1050	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Per2 is a C/EBP target gene implicated in myeloid_leukemia .
23496259	0	Per2	55,59	TNF-a	0,5	Per2	TNF-a	8864	7124	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	TNF-a modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells .
17599055	0	Per2	15,19	estrogen_receptor	54,71	Per2	estrogen receptor	8864	2099	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	The clock gene Per2 links the circadian system to the estrogen_receptor .
21070773	0	Per3	0,4	Chk2	40,44	Per3	Chk2	8863	11200	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	Per3 , a circadian gene , is required for Chk2 activation in human cells .
18039972	0	Perdido	26,33	Grip	49,53	Perdido	Grip	35104(Tax:7227)	50391(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo .
20049450	0	Perforin	0,8	CD4	18,21	Perforin	CD4	5551	920	Gene	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	Perforin level in CD4 + T cells from patients with systemic_lupus_erythematosus .
26307549	0	Perforin-2	0,10	Mpeg1	11,16	Perforin-2	Mpeg1	219972	219972	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Perforin-2 / Mpeg1 and other pore-forming proteins throughout evolution .
19570032	0	Period2	39,46	clock	28,33	Period2	clock	18627(Tax:10090)	12753(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the circadian clock gene Period2 in the hippocampus : possible implications for synaptic plasticity and learned behaviour .
22166120	0	Period2	41,48	hPer2	50,55	Period2	hPer2	8864	8864	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of circadian clock gene human Period2 -LRB- hPer2 -RRB- in human colorectal_carcinoma .
24051492	0	Period2	14,21	p53	0,3	Period2	p53	18627(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p53 regulates Period2 expression and the circadian clock .
23816566	0	Period_2	52,60	PER2	62,66	Period 2	PER2	8864	8864	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Egr1 regulates lithium-induced transcription of the Period_2 -LRB- PER2 -RRB- gene .
24323465	0	Periostin	0,9	TGFbIp	60,66	Periostin	TGFbIp	50706(Tax:10090)	21810(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Periostin and transforming growth factor b-induced protein -LRB- TGFbIp -RRB- are both expressed by osteoblasts and osteoclasts .
23917221	0	Periostin	0,9	p53	33,36	Periostin	p53	10631	7157	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal_tumor microenvironment .
15130769	0	Peripheral-type_benzodiazepine_receptor	0,39	ERK	126,129	Peripheral-type benzodiazepine receptor	ERK	706	5594	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Peripheral-type_benzodiazepine_receptor -LRB- PBR -RRB- and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation : role of ERK , c-Jun and ligand-activated PBR-independent pathways .
8292358	0	Perlecan	51,59	heparan_sulfate_proteoglycan	21,49	Perlecan	heparan sulfate proteoglycan	313641(Tax:10116)	25615(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	An important role of heparan_sulfate_proteoglycan -LRB- Perlecan -RRB- in a model system for the deposition and persistence of fibrillar A_beta-amyloid in rat brain .
16153598	0	Peroxidase	0,10	annexin_1	23,32	Peroxidase	annexin 1	816773(Tax:3702)	840476(Tax:3702)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Peroxidase activity of annexin_1 from Arabidopsis_thaliana .
19267995	0	Peroxidase	0,10	cytochrome_C	23,35	Peroxidase	cytochrome C	2768671(Tax:7227)	34995(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Peroxidase activity of cytochrome_C facilitates the protoporphyrinogen_oxidase reaction .
20018613	0	Peroxiredoxin_1	0,15	TLR4	80,84	Peroxiredoxin 1	TLR4	18477(Tax:10090)	21898(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Peroxiredoxin_1 stimulates secretion of proinflammatory cytokines by binding to TLR4 .
17909037	0	Peroxiredoxin_1	0,15	androgen_receptor	31,48	Peroxiredoxin 1	androgen receptor	5052	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Peroxiredoxin_1 interacts with androgen_receptor and enhances its transactivation .
21539911	0	Peroxiredoxin_2	0,15	androgen_receptor	66,83	Peroxiredoxin 2	androgen receptor	7001	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Peroxiredoxin_2 in the nucleus and cytoplasm distinctly regulates androgen_receptor activity in prostate_cancer cells .
16045763	0	Peroxiredoxin_II	0,16	phospholipase_D1	69,85	Peroxiredoxin II	phospholipase D1	7001	5337	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Peroxiredoxin_II functions as a signal terminator for H2O2-activated phospholipase_D1 .
23831231	0	Peroxiredoxin_V	0,15	IL-6	38,42	Peroxiredoxin V	IL-6	25824	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Peroxiredoxin_V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway .
16442504	0	Peroxisome-proliferator-activated_receptor-gamma	0,48	PPARgamma	50,59	Peroxisome-proliferator-activated receptor-gamma	PPARgamma	5468	5468	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Peroxisome-proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- activation protects neurons from NMDA excitotoxicity .
26336103	0	Peroxisome_Proliferative-activated_Receptor-y	100,145	PPARy	147,152	Peroxisome Proliferative-activated Receptor-y	PPARy	5468	5468	Gene	Gene	Activation|compound|START_ENTITY Activation|appos|END_ENTITY	The Synergistic Enhancement of Cloning Efficiency in Individualized Human Pluripotent Stem Cells by Peroxisome_Proliferative-activated_Receptor-y -LRB- PPARy -RRB- Activation and Rho-associated Kinase -LRB- ROCK -RRB- Inhibition .
24855517	0	Peroxisome_Proliferator-Activated_Receptor	8,50	PPAR	52,56	Peroxisome Proliferator-Activated Receptor	PPAR	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Peroxisome_Proliferator-Activated_Receptor -LRB- PPAR -RRB- in Embryonic Stem Cell Proliferation .
26465636	0	Peroxisome_Proliferator-Activated_Receptor_Alpha	76,124	Breast_Cancer_Resistant_Protein	34,65	Peroxisome Proliferator-Activated Receptor Alpha	Breast Cancer Resistant Protein	19013(Tax:10090)	26357(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	In Vivo and Ex Vivo Regulation of Breast_Cancer_Resistant_Protein -LRB- Bcrp -RRB- by Peroxisome_Proliferator-Activated_Receptor_Alpha -LRB- Ppara -RRB- at the Blood-Brain Barrier .
24118591	0	Peroxisome_Proliferator-Activated_Receptor_Delta	29,77	PPARD	79,84	Peroxisome Proliferator-Activated Receptor Delta	PPARD	5467	5467	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic haplotype within the Peroxisome_Proliferator-Activated_Receptor_Delta -LRB- PPARD -RRB- gene is associated with elite athletic status .
26275398	0	Peroxisome_Proliferator-Activated_Receptor_Gamma	0,48	Connexin43	92,102	Peroxisome Proliferator-Activated Receptor Gamma	Connexin43	25664(Tax:10116)	24392(Tax:10116)	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-b1 / Smads Signaling in a Rat Model of Myocardial_Infarction .
25986483	0	Peroxisome_Proliferator-Activated_Receptor_Gamma	68,116	PPAR-y	118,124	Peroxisome Proliferator-Activated Receptor Gamma	PPAR-y	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A candidate gene study reveals association between a variant of the Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPAR-y -RRB- gene and systemic_sclerosis .
25986483	0	Peroxisome_Proliferator-Activated_Receptor_Gamma	68,116	PPAR-y	118,124	Peroxisome Proliferator-Activated Receptor Gamma	PPAR-y	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A candidate gene study reveals association between a variant of the Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPAR-y -RRB- gene and systemic_sclerosis .
25987855	0	Peroxisome_Proliferator-Activated_Receptor_Gamma	13,61	PPARy	63,68	Peroxisome Proliferator-Activated Receptor Gamma	PPARy	5468	5468	Gene	Gene	Functions|nmod|START_ENTITY Functions|appos|END_ENTITY	Functions of Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPARy -RRB- in Gynecologic_Disorders .
25987855	0	Peroxisome_Proliferator-Activated_Receptor_Gamma	13,61	PPARy	63,68	Peroxisome Proliferator-Activated Receptor Gamma	PPARy	5468	5468	Gene	Gene	Functions|nmod|START_ENTITY Functions|appos|END_ENTITY	Functions of Peroxisome_Proliferator-Activated_Receptor_Gamma -LRB- PPARy -RRB- in Gynecologic_Disorders .
26309807	0	Peroxisome_Proliferator-Activated_Receptor_Gamma	35,83	PTB-Associated_Splicing_Factor	4,34	Peroxisome Proliferator-Activated Receptor Gamma	PTB-Associated Splicing Factor	5468	6421	Gene	Gene	Axis|compound|START_ENTITY Regulates|nsubj|Axis END_ENTITY|parataxis|Regulates	The PTB-Associated_Splicing_Factor / Peroxisome_Proliferator-Activated_Receptor_Gamma Axis Regulates Autophagosome Formation in Human Pancreatic_Cancer Cells .
26275398	0	Peroxisome_Proliferator-Activated_Receptor_Gamma	0,48	TGF-b1	125,131	Peroxisome Proliferator-Activated Receptor Gamma	TGF-b1	25664(Tax:10116)	59086(Tax:10116)	Gene	Gene	Cells|compound|START_ENTITY Cells|nmod|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-b1 / Smads Signaling in a Rat Model of Myocardial_Infarction .
26491197	0	Peroxisome_Proliferator-Activated_Receptor_a	13,57	Th1	88,91	Peroxisome Proliferator-Activated Receptor a	Th1	19013(Tax:10090)	57314(Tax:10090)	Gene	Gene	Immunity|compound|START_ENTITY Immunity|compound|END_ENTITY	Antagonizing Peroxisome_Proliferator-Activated_Receptor_a Activity Selectively Enhances Th1 Immunity in Male Mice .
24955089	0	Peroxisome_Proliferator-Activated_Receptor_y	0,44	Lipid_Phosphate_Phosphohydrolase_1	73,107	Peroxisome Proliferator-Activated Receptor y	Lipid Phosphate Phosphohydrolase 1	5468	8611	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|nmod|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_y Regulates the Expression of Lipid_Phosphate_Phosphohydrolase_1 in Human Vascular Endothelial Cells .
26219505	0	Peroxisome_Proliferator_Activated_Receptor	36,78	PPAR	80,84	Peroxisome Proliferator Activated Receptor	PPAR	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Triptolide disrupts fatty_acids and Peroxisome_Proliferator_Activated_Receptor -LRB- PPAR -RRB- levels in male mice testes followed by testicular_injury : A GC-MS based metabolomics study .
26219505	0	Peroxisome_Proliferator_Activated_Receptor	36,78	PPAR	80,84	Peroxisome Proliferator Activated Receptor	PPAR	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Triptolide disrupts fatty_acids and Peroxisome_Proliferator_Activated_Receptor -LRB- PPAR -RRB- levels in male mice testes followed by testicular_injury : A GC-MS based metabolomics study .
25896411	0	Peroxisome_Proliferator_Activated_Receptor-Gamma	41,89	PPAR-y	91,97	Peroxisome Proliferator Activated Receptor-Gamma	PPAR-y	5468	5468	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Impact of the C1431T Polymorphism of the Peroxisome_Proliferator_Activated_Receptor-Gamma -LRB- PPAR-y -RRB- Gene on Fasted Serum Lipid Levels in Patients with Coronary_Artery_Disease .
25924962	0	Peroxisome_Proliferator_Activated_Receptor_Delta	58,106	PPAR	108,112	Peroxisome Proliferator Activated Receptor Delta	PPAR	100053404(Tax:9796)	100053404(Tax:9796)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Molecular Characterization and Expression Analysis of the Peroxisome_Proliferator_Activated_Receptor_Delta -LRB- PPAR -RRB- Gene before and after Exercise in Horse .
15059948	0	Peroxisome_proliferator-activated_receptor	0,42	PPAR	44,48	Peroxisome proliferator-activated receptor	PPAR	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- activation induces tissue-specific effects on fatty_acid uptake and metabolism in vivo -- a study using the novel PPARalpha/gamma agonist tesaglitazar .
21245137	0	Peroxisome_proliferator-activated_receptor	0,42	PPAR	44,48	Peroxisome proliferator-activated receptor	PPAR	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- gene profiling uncovers insulin-like_growth_factor-1 as a PPARalpha target gene in cardioprotection .
19458633	0	Peroxisome_proliferator-activated_receptor-alpha	0,48	p63	75,78	Peroxisome proliferator-activated receptor-alpha	p63	5465	8626	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor-alpha is a functional target of p63 in adult human keratinocytes .
12777391	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	GLUT4	59,64	Peroxisome proliferator-activated receptor-gamma	GLUT4	25664(Tax:10116)	25139(Tax:10116)	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	Peroxisome_proliferator-activated_receptor-gamma represses GLUT4 promoter activity in primary adipocytes , and rosiglitazone alleviates this effect .
17192469	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	PDX-1	73,78	Peroxisome proliferator-activated receptor-gamma	PDX-1	25664(Tax:10116)	29535(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma regulates expression of PDX-1 and NKX6 .1 in INS-1 cells .
12468449	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	PPAR-gamma	50,60	Peroxisome proliferator-activated receptor-gamma	PPAR-gamma	19016(Tax:10090)	19016(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets .
20484463	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	adiponectin	59,70	Peroxisome proliferator-activated receptor-gamma	adiponectin	5468	9370	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44 .
12813462	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	caveolin-1	61,71	Peroxisome proliferator-activated receptor-gamma	caveolin-1	5468	857	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells .
15533896	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	cyclooxygenase-2	60,76	Peroxisome proliferator-activated receptor-gamma	cyclooxygenase-2	5468	5743	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma suppresses cyclooxygenase-2 expression in human prostate cells .
16269451	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	hormone-sensitive_lipase	80,104	Peroxisome proliferator-activated receptor-gamma	hormone-sensitive lipase	5468	3991	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Peroxisome_proliferator-activated_receptor-gamma transcriptionally up-regulates hormone-sensitive_lipase via the involvement of specificity_protein-1 .
16887883	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	p53	59,62	Peroxisome proliferator-activated receptor-gamma	p53	5468	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast_cancer cells .
19861583	0	Peroxisome_proliferator-activated_receptor-gamma	0,48	very-low-density_lipoprotein_receptor	90,127	Peroxisome proliferator-activated receptor-gamma	very-low-density lipoprotein receptor	19016(Tax:10090)	22359(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma regulates the expression and function of very-low-density_lipoprotein_receptor .
22168458	0	Peroxisome_proliferator-activated_receptor_a	0,44	PPARa	46,51	Peroxisome proliferator-activated receptor a	PPARa	5465	5465	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_a -LRB- PPARa -RRB- mRNA expression in human hepatocellular_carcinoma tissue and non-cancerous liver tissue .
23168409	0	Peroxisome_proliferator-activated_receptor_a	0,44	complement_C3	66,79	Peroxisome proliferator-activated receptor a	complement C3	5465	718	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_a positively regulates complement_C3 expression but inhibits tumor necrosis factor a-mediated activation of C3 gene in mammalian hepatic-derived cells .
19289130	0	Peroxisome_proliferator-activated_receptor_alpha	0,48	ALAS1	92,97	Peroxisome proliferator-activated receptor alpha	ALAS1	5465	211	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha controls hepatic heme biosynthesis through ALAS1 .
8663275	0	Peroxisome_proliferator-activated_receptor_alpha	0,48	S14	66,69	Peroxisome proliferator-activated receptor alpha	S14	25747(Tax:10116)	25357(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha inhibits hepatic S14 gene transcription .
12816998	0	Peroxisome_proliferator-activated_receptor_alpha	0,48	T-bet	70,75	Peroxisome proliferator-activated receptor alpha	T-bet	19013(Tax:10090)	57765(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation .
18648741	0	Peroxisome_proliferator-activated_receptor_alpha	0,48	cyclooxygenase-2	59,75	Peroxisome proliferator-activated receptor alpha	cyclooxygenase-2	5465	5743	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha activates cyclooxygenase-2 gene transcription through bile_acid transport in human colorectal_cancer cell lines .
16226051	0	Peroxisome_proliferator-activated_receptor_alpha	0,48	estrogen_receptor_alpha	76,99	Peroxisome proliferator-activated receptor alpha	estrogen receptor alpha	5465	2099	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha expression is regulated by estrogen_receptor_alpha and modulates the response of MCF-7 cells to sodium_butyrate .
22318764	0	Peroxisome_proliferator-activated_receptor_alpha	0,48	uncoupling_protein_2	62,82	Peroxisome proliferator-activated receptor alpha	uncoupling protein 2	19013(Tax:10090)	22228(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha induction of uncoupling_protein_2 protects against acetaminophen-induced liver toxicity .
16337160	0	Peroxisome_proliferator-activated_receptor_delta	0,48	PPARdelta	50,59	Peroxisome proliferator-activated receptor delta	PPARdelta	25682(Tax:10116)	25682(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_delta -LRB- PPARdelta -RRB- activation protects H9c2 cardiomyoblasts from oxidative stress-induced apoptosis .
17015477	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	E-cadherin	59,69	Peroxisome proliferator-activated receptor gamma	E-cadherin	19016(Tax:10090)	12550(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma regulates E-cadherin expression and inhibits growth and invasion of prostate_cancer .
19633298	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	G-protein-coupled_receptor_81	92,121	Peroxisome proliferator-activated receptor gamma	G-protein-coupled receptor 81	5468	27198	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma regulates expression of the anti-lipolytic G-protein-coupled_receptor_81 -LRB- GPR81/Gpr81 -RRB- .
15758247	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	PPAR-gamma	50,60	Peroxisome proliferator-activated receptor gamma	PPAR-gamma	5468	5468	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- agonist increases plasma adiponectin levels in type 2 diabetic patients with proteinuria .
12714563	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	PPARgamma	50,59	Peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression is decreased in pulmonary hypertension and affects endothelial cell growth .
17178896	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	Zac	54,57	Peroxisome proliferator-activated receptor gamma	Zac	5468	353174	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma is a Zac target gene mediating Zac antiproliferation .
11590167	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	connective_tissue_growth_factor	98,129	Peroxisome proliferator-activated receptor gamma	connective tissue growth factor	5468	1490	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|transforming transforming|dobj|expression expression|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma inhibits transforming growth factor beta-induced connective_tissue_growth_factor expression in human aortic smooth muscle cells by interfering with Smad3 .
19620052	0	Peroxisome_proliferator-activated_receptor_gamma	1,49	connective_tissue_growth_factor	100,131	Peroxisome proliferator-activated receptor gamma	connective tissue growth factor	25664(Tax:10116)	64032(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	-LSB- Peroxisome_proliferator-activated_receptor_gamma inhibits transforming_growth_factor_beta1-induced connective_tissue_growth_factor expression in rat hepatic stellate cells -RSB- .
11598137	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	p21	88,91	Peroxisome proliferator-activated receptor gamma	p21	25664(Tax:10116)	24525(Tax:10116)	Gene	Gene	ligands|amod|START_ENTITY inhibit|nsubj|ligands inhibit|dobj|induction induction|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma ligands inhibit mitogenic induction of p21 -LRB- Cip1 -RRB- by modulating the protein_kinase_Cdelta pathway in vascular smooth muscle cells .
16457814	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	signal_transducer_and_activator_of_transcription_5A	73,124	Peroxisome proliferator-activated receptor gamma	signal transducer and activator of transcription 5A	19016(Tax:10090)	20850(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma regulates expression of signal_transducer_and_activator_of_transcription_5A .
23372933	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	thrombospondin-1	67,83	Peroxisome proliferator-activated receptor gamma	thrombospondin-1	5468	7057	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARy -RRB- regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation .
17118693	0	Peroxisome_proliferator-activated_receptor_gamma	0,48	trefoil_factor_family_2	71,94	Peroxisome proliferator-activated receptor gamma	trefoil factor family 2	5468	7032	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- regulates trefoil_factor_family_2 -LRB- TFF2 -RRB- expression in gastric epithelial cells .
19884383	0	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	0,67	androgen_receptor	87,104	Peroxisome proliferator-activated receptor gamma coactivator-1alpha	androgen receptor	10891	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha interacts with the androgen_receptor -LRB- AR -RRB- and promotes prostate_cancer cell growth by activating the AR .
19602572	0	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	0,67	uridine_phosphorylase	169,190	Peroxisome proliferator-activated receptor gamma coactivator-1alpha	uridine phosphorylase	10891	7378	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|induction induction|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha enhances antiproliferative activity of 5 ' - deoxy-5-fluorouridine in cancer cells through induction of uridine_phosphorylase .
18855124	0	Personal_and_Social_Performance_scale	31,68	PSP	70,73	Personal and Social Performance scale	PSP	140683	140683	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Psychometric properties of the Personal_and_Social_Performance_scale -LRB- PSP -RRB- among individuals with schizophrenia living in the community .
15916616	0	Pet111p	52,59	COX2	22,26	Pet111p	COX2	855299(Tax:4932)	854622(Tax:4932)	Gene	Gene	activator|appos|START_ENTITY activator|compound|END_ENTITY	Overexpression of the COX2 translational activator , Pet111p , prevents translation of COX1 mRNA and cytochrome c oxidase assembly in mitochondria of Saccharomyces_cerevisiae .
25941407	0	Pex11p	32,38	Dnm1p	60,65	Pex11p	Dnm1p	854018(Tax:4932)	1759	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The membrane remodeling protein Pex11p activates the GTPase Dnm1p during peroxisomal fission .
19197237	0	Pex14	49,54	Pex5	81,85	Pex14	Pex5	5195	5830	Gene	Gene	interactions|nmod|START_ENTITY basis|nmod|interactions receptors|nsubj|basis receptors|dobj|END_ENTITY	Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19 .
24235149	0	Pex14	8,13	Pex5	48,52	Pex14	Pex5	5195	5830	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes .
10660573	0	Pex14p	110,116	Pex5p	15,20	Pex14p	Pex5p	5195	5830	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Pex5p , the type 1 peroxisome targeting signal receptor , with the peroxisomal membrane proteins Pex14p and Pex13p .
15949802	0	Pex14p	25,31	Pex5p	57,62	Pex14p	Pex5p	852724(Tax:4932)	851831(Tax:4932)	Gene	Gene	contains|nsubj|START_ENTITY contains|dobj|sites sites|amod|END_ENTITY	Saccharomyces_cerevisiae Pex14p contains two independent Pex5p binding sites , which are both essential for PTS1 protein import .
16107331	0	Pex14p	6,12	Pex5p	49,54	Pex14p	Pex5p	852724(Tax:4932)	851831(Tax:4932)	Gene	Gene	possesses|nsubj|START_ENTITY possesses|dobj|END_ENTITY	Yeast Pex14p possesses two functionally distinct Pex5p and one Pex7p binding sites .
23009329	0	Pex14p	17,23	Pex5p	0,5	Pex14p	Pex5p	100769796	100689015	Gene	Gene	START_ENTITY|nummod|stabilizes stabilizes|compound|END_ENTITY	Pex5p stabilizes Pex14p : a study using a newly isolated pex5 CHO cell mutant , ZPEG101 .
9312008	0	Pex14p	0,6	Pex5p	49,54	Pex14p	Pex5p	852724(Tax:4932)	851831(Tax:4932)	Gene	Gene	member|nsubj|START_ENTITY member|nmod|map map|nmod|END_ENTITY	Pex14p is a member of the protein linkage map of Pex5p .
16551610	0	Pex19p	0,6	Pex30p	13,19	Pex19p	Pex30p	851494(Tax:4932)	851034(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Pex19p binds Pex30p and Pex32p at regions required for their peroxisomal localization but separate from their peroxisomal targeting signals .
10359594	0	Pex19p	0,6	Pex3p	22,27	Pex19p	Pex3p	851494(Tax:4932)	851929(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia_pastoris .
16895967	0	Pex19p	37,43	Pex3p	62,67	Pex19p	Pex3p	5824	8504	Gene	Gene	START_ENTITY|dep|interaction interaction|nmod|END_ENTITY	Functional domain mapping of peroxin Pex19p : interaction with Pex3p is essential for function and translocation .
19114594	0	Pex19p	105,111	Pex3p	49,54	Pex19p	Pex3p	5824	8504	Gene	Gene	pathway|amod|START_ENTITY transported|nmod|pathway transported|nsubjpass|END_ENTITY	The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p - and Pex16p-dependent pathway .
21102411	0	Pex19p	69,75	Pex3p	94,99	Pex19p	Pex3p	5824	8504	Gene	Gene	docking|nmod|START_ENTITY docking|nmod|END_ENTITY	Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p .
16551610	0	Pex30p	13,19	Pex19p	0,6	Pex30p	Pex19p	851034(Tax:4932)	851494(Tax:4932)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Pex19p binds Pex30p and Pex32p at regions required for their peroxisomal localization but separate from their peroxisomal targeting signals .
10359594	0	Pex3p	22,27	Pex19p	0,6	Pex3p	Pex19p	851929(Tax:4932)	851494(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia_pastoris .
16895967	0	Pex3p	62,67	Pex19p	37,43	Pex3p	Pex19p	8504	5824	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	Functional domain mapping of peroxin Pex19p : interaction with Pex3p is essential for function and translocation .
19114594	0	Pex3p	49,54	Pex19p	105,111	Pex3p	Pex19p	8504	5824	Gene	Gene	transported|nsubjpass|START_ENTITY transported|nmod|pathway pathway|amod|END_ENTITY	The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p - and Pex16p-dependent pathway .
21102411	0	Pex3p	94,99	Pex19p	69,75	Pex3p	Pex19p	8504	5824	Gene	Gene	docking|nmod|START_ENTITY docking|nmod|END_ENTITY	Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p .
19197237	0	Pex5	81,85	Pex14	49,54	Pex5	Pex14	5830	5195	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|basis basis|nmod|interactions interactions|nmod|END_ENTITY	Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19 .
24235149	0	Pex5	48,52	Pex14	8,13	Pex5	Pex14	5830	5195	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes .
10660573	0	Pex5p	15,20	Pex14p	110,116	Pex5p	Pex14p	5830	5195	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Pex5p , the type 1 peroxisome targeting signal receptor , with the peroxisomal membrane proteins Pex14p and Pex13p .
15949802	0	Pex5p	57,62	Pex14p	25,31	Pex5p	Pex14p	851831(Tax:4932)	852724(Tax:4932)	Gene	Gene	sites|amod|START_ENTITY contains|dobj|sites contains|nsubj|END_ENTITY	Saccharomyces_cerevisiae Pex14p contains two independent Pex5p binding sites , which are both essential for PTS1 protein import .
16107331	0	Pex5p	49,54	Pex14p	6,12	Pex5p	Pex14p	851831(Tax:4932)	852724(Tax:4932)	Gene	Gene	possesses|dobj|START_ENTITY possesses|nsubj|END_ENTITY	Yeast Pex14p possesses two functionally distinct Pex5p and one Pex7p binding sites .
23009329	0	Pex5p	0,5	Pex14p	17,23	Pex5p	Pex14p	100689015	100769796	Gene	Gene	stabilizes|compound|START_ENTITY END_ENTITY|nummod|stabilizes	Pex5p stabilizes Pex14p : a study using a newly isolated pex5 CHO cell mutant , ZPEG101 .
9312008	0	Pex5p	49,54	Pex14p	0,6	Pex5p	Pex14p	851831(Tax:4932)	852724(Tax:4932)	Gene	Gene	map|nmod|START_ENTITY member|nmod|map member|nsubj|END_ENTITY	Pex14p is a member of the protein linkage map of Pex5p .
2095003	0	Pfp	87,90	perforin	77,85	Pfp	perforin	5551	18646(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Novel putative promoter/enhancer sequences are shared by the mouse and human perforin -LRB- Pfp -RRB- genes .
16160620	0	PgP	40,43	CYP2D6	45,51	PgP	CYP2D6	283871	1565	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
16160620	0	PgP	40,43	GSTM1	26,31	PgP	GSTM1	283871	2944	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|compound|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
16160620	0	PgP	40,43	GSTT1	33,38	PgP	GSTT1	283871	2952	Gene	Gene	CYP3A5|appos|START_ENTITY CYP3A5|appos|END_ENTITY	Polymorphic variations in GSTM1 , GSTT1 , PgP , CYP2D6 , CYP3A5 , and dopamine D2 and D3 receptors and their association with tardive_dyskinesia in severe mental_illness .
25037596	0	PgR	55,58	progesterone_receptor	27,48	PgR	progesterone receptor	5241	5241	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the +331 G/A progesterone_receptor gene -LRB- PgR -RRB- polymorphism with risk of endometrial_cancer in Caucasian women : a meta-analysis .
1465095	0	Pgk	57,60	phosphoglycerate_kinase	32,55	Pgk	phosphoglycerate kinase	33461(Tax:7227)	33461(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and expression of the phosphoglycerate_kinase -LRB- Pgk -RRB- gene of Drosophila_melanogaster .
10500781	0	Pgp	58,61	MDR-1_and_MDR-3	42,57	Pgp	MDR-1 and MDR-3	283871	5243;5244	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Preliminary immunocytochemical studies of MDR-1_and_MDR-3 Pgp expression in B-cell_leukaemias .
10532420	0	Pgp	55,58	P-glycoprotein	39,53	Pgp	P-glycoprotein	5243	5243	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the multidrug-resistance P-glycoprotein -LRB- Pgp , MDR-1 -RRB- by endothelial cells of the neovasculature in central_nervous_system_tumors .
16595917	0	Pgp	78,81	P-glycoprotein	62,76	Pgp	P-glycoprotein	287115(Tax:10116)	287115(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Relationship between excretion clearance of rhodamine_123 and P-glycoprotein -LRB- Pgp -RRB- expression induced by representative Pgp inducers .
26790551	0	Pgp	30,33	P-glycoprotein	14,28	Pgp	P-glycoprotein	5243	5243	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Evaluation of P-glycoprotein -LRB- Pgp -RRB- expression in human osteosarcoma by high-throughput tissue_microarray .
8845477	0	Pgp	53,56	P-glycoprotein	37,51	Pgp	P-glycoprotein	5243	5243	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Decreased uptake of cyclosporin_A by P-glycoprotein -LRB- Pgp -RRB- expressing CEM_leukemic cells and restoration of normal retention by Pgp blockers .
22879045	0	Pgp	85,88	p-glycoprotein	69,83	Pgp	p-glycoprotein	5243	5243	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	PET imaging of the impact of extracellular pH and MAP kinases on the p-glycoprotein -LRB- Pgp -RRB- activity .
1689752	0	Pgp-1	97,102	CD44	92,96	Pgp-1	CD44	960	960	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Homotypic cell aggregation induced by anti-CD44 -LRB- Pgp-1 -RRB- monoclonal antibodies and related to CD44 -LRB- Pgp-1 -RRB- expression .
1902176	0	Pgp-1	117,122	CD44	124,128	Pgp-1	CD44	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Elevated production of interferon-gamma and interleukin_4 by mature T cells from autoimmune lpr mice correlates with Pgp-1 -LRB- CD44 -RRB- expression .
2246506	0	Pgp-1	15,20	IL-5	0,4	Pgp-1	IL-5	960	3567	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	IL-5 induces a Pgp-1 -LRB- CD44 -RRB- bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate .
2192903	0	Pgp-1	23,28	Ly-24	30,35	Pgp-1	Ly-24	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elevated expression of Pgp-1 -LRB- Ly-24 -RRB- by murine peritoneal B lymphocytes .
2784763	0	Pgp-1	33,38	Ly-24	26,31	Pgp-1	Ly-24	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mouse_strain variation in Ly-24 -LRB- Pgp-1 -RRB- expression by peripheral T cells and thymocytes : implications for T cell differentiation .
3102251	0	Pgp-1	14,19	Ly24	24,28	Pgp-1	Ly24	12505(Tax:10090)	12505(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of Pgp-1 -LRB- or Ly24 -RRB- by subpopulations of mouse thymocytes and activated peripheral T lymphocytes .
7540608	0	Ph1	119,122	CD34	125,129	Ph1	CD34	189	12490(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	Direct transplantation of chronic_myelogenous_leukemia cells into nude_mice and establishment of a leukemic stem cell -LRB- Ph1 + , CD34 + -RRB- line dependent on mouse bone marrow stromal cells in vitro .
22174782	0	PhLP3	40,45	phosducin-like_protein_3	14,38	PhLP3	phosducin-like protein 3	79031	79031	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Modulation of phosducin-like_protein_3 -LRB- PhLP3 -RRB- levels promotes cytoskeletal remodelling in a MAPK and RhoA-dependent manner .
23041370	0	Phactr1	18,25	RPEL	26,30	Phactr1	RPEL	221692	221692	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity .
18295233	0	Phactr3	49,56	scapinin	39,47	Phactr3	scapinin	74189(Tax:10090)	74189(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Paramutation-like effects at the mouse scapinin -LRB- Phactr3 -RRB- locus .
22816767	0	Phafin_2	29,37	epidermal_growth_factor_receptor	47,79	Phafin 2	epidermal growth factor receptor	79666	1956	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|degradation degradation|compound|END_ENTITY	The PtdIns3P-binding protein Phafin_2 mediates epidermal_growth_factor_receptor degradation by promoting endosome fusion .
26562260	0	Phd2	72,76	Prolyl_Hydroxylase_Domain-Containing_Protein_2	24,70	Phd2	Prolyl Hydroxylase Domain-Containing Protein 2	112405(Tax:10090)	112405(Tax:10090)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Conditional Deletion of Prolyl_Hydroxylase_Domain-Containing_Protein_2 -LRB- Phd2 -RRB- Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation .
24753072	0	Phd2	78,82	prolyl_hydroxylase_domain-containing_protein_2	30,76	Phd2	prolyl hydroxylase domain-containing protein 2	112405(Tax:10090)	112405(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Conditional disruption of the prolyl_hydroxylase_domain-containing_protein_2 -LRB- Phd2 -RRB- gene defines its key role in skeletal development .
25161887	0	Phd3	16,20	ERa	0,3	Phd3	ERa	112399	2099	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	ERa upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue .
11378842	0	Phenylethanolamine_N-methyltransferase	0,38	PNMT	40,44	Phenylethanolamine N-methyltransferase	PNMT	5409	5409	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- gene and early-onset Alzheimer_disease .
12220505	0	Phex	31,35	MEPE	14,18	Phex	MEPE	18675(Tax:10090)	94111(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of MEPE cleavage by Phex .
19429008	0	Phgdh	60,65	3-phosphoglycerate_dehydrogenase	26,58	Phgdh	3-phosphoglycerate dehydrogenase	26227	26227	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Selective upregulation of 3-phosphoglycerate_dehydrogenase -LRB- Phgdh -RRB- expression in adult subventricular zone neurogenic niche .
10054316	0	Phi	64,67	Phi	72,75	Phi	Phi	2821	2821	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	New measurements of the neutral kaon parameters Delta m , tau S , Phi 00 - Phi + - , and Phi + -
10054316	0	Phi	72,75	Phi	64,67	Phi	Phi	2821	2821	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	New measurements of the neutral kaon parameters Delta m , tau S , Phi 00 - Phi + - , and Phi + -
16215179	0	Pho2	24,28	Bas1	10,14	Pho2	Bas1	851452(Tax:4932)	853974(Tax:4932)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces_cerevisiae .
8948638	0	Pho2	24,28	PHO5	109,113	Pho2	PHO5	851452(Tax:4932)	852390(Tax:4932)	Gene	Gene	Pho4|nsubj|START_ENTITY Pho4|nmod|promoter promoter|compound|END_ENTITY	The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter .
7957054	0	Pho4	59,63	PHO5	105,109	Pho4	PHO5	850594(Tax:4932)	852390(Tax:4932)	Gene	Gene	precludes|dobj|START_ENTITY precludes|nmod|site site|nmod|promoter promoter|compound|END_ENTITY	A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter .
8948638	0	Pho4	68,72	PHO5	109,113	Pho4	PHO5	850594(Tax:4932)	852390(Tax:4932)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter .
9566882	0	Pho4	84,88	PHO5	42,46	Pho4	PHO5	850594(Tax:4932)	852390(Tax:4932)	Gene	Gene	binding|nmod|START_ENTITY critical|nmod|binding critical|nsubj|interactions interactions|nmod|promoter promoter|compound|END_ENTITY	Cooperative Pho2-Pho4 interactions at the PHO5 promoter are critical for binding of Pho4 to UASp1 and for efficient transactivation by Pho4 at UASp2 .
16964260	0	Pho85	4,9	Sic1	32,36	Pho85	Sic1	856076(Tax:4932)	850768(Tax:4932)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage .
10490639	0	Pho85p	57,63	Pcl10p	78,84	Pho85p	Pcl10p	856076(Tax:4932)	852743(Tax:4932)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Substrate targeting of the yeast cyclin-dependent kinase Pho85p by the cyclin Pcl10p .
9551090	0	Phosducin-like_protein	0,22	SUG1	108,112	Phosducin-like protein	SUG1	67466(Tax:10090)	19184(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Phosducin-like_protein -LRB- PhLP -RRB- , a regulator of G beta gamma function , interacts with the proteasomal protein SUG1 .
25378403	0	Phosphatase_2A	125,139	Caspase-2	83,92	Phosphatase 2A	Caspase-2	5524	835	Gene	Gene	Suppression|nmod|START_ENTITY Suppression|compound|END_ENTITY	Metabolic Control of Ca2 + / Calmodulin-dependent Protein Kinase II -LRB- CaMKII -RRB- - mediated Caspase-2 Suppression by the B55b/Protein Phosphatase_2A -LRB- PP2A -RRB- .
26717153	0	Phosphatase_4	23,36	TIPRL	0,5	Phosphatase 4	TIPRL	5531	261726	Gene	Gene	Activity|compound|START_ENTITY Inhibits|dobj|Activity Inhibits|nsubj|END_ENTITY	TIPRL Inhibits Protein Phosphatase_4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response .
25139404	0	Phosphatase_of_regenerating_liver-3	0,35	STAT3	60,65	Phosphatase of regenerating liver-3	STAT3	11156	6774	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Phosphatase_of_regenerating_liver-3 -LRB- PRL-3 -RRB- is regulated by STAT3 in acute_myeloid_leukemia .
22791713	0	Phosphatase_of_regenerating_liver_2	0,35	PTEN	101,105	Phosphatase of regenerating liver 2	PTEN	8073	5728	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Phosphatase_of_regenerating_liver_2 -LRB- PRL2 -RRB- is essential for placental development by down-regulating PTEN -LRB- Phosphatase_and_Tensin_Homologue_Deleted_on_Chromosome_10 -RRB- and activating Akt protein .
23901139	0	Phosphatidylcholine_transfer_protein	0,36	thioesterase_superfamily_member_2	52,85	Phosphatidylcholine transfer protein	thioesterase superfamily member 2	18559(Tax:10090)	66834(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Phosphatidylcholine_transfer_protein interacts with thioesterase_superfamily_member_2 to attenuate insulin signaling .
18391955	0	Phosphatidylinositol-3-OH_kinase	0,32	mTOR	54,58	Phosphatidylinositol-3-OH kinase	mTOR	5293	21977(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Phosphatidylinositol-3-OH_kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking .
25158146	0	Phosphatidylinositol-3-kinase	0,29	IPS-1	116,121	Phosphatidylinositol-3-kinase	IPS-1	5293	57506	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Phosphatidylinositol-3-kinase and Akt are required for RIG-I-mediated anti-viral signalling through cross-talk with IPS-1 .
19520917	0	Phosphatidylinositol-3-kinase	0,29	akt	30,33	Phosphatidylinositol-3-kinase	akt	5290	207	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphatidylinositol-3-kinase / akt regulates bleomycin-induced fibroblast proliferation and collagen production .
15288510	0	Phosphatidylinositol-3_kinase	0,29	Akt	30,33	Phosphatidylinositol-3 kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|mediated mediated|nsubj|END_ENTITY	Phosphatidylinositol-3_kinase / Akt and GSK-3 mediated cytoprotective effect of epigallocatechin_gallate on oxidative stress-injured neuronal-differentiated N18D3 cells .
25900077	0	Phosphatidylinositol_3-Kinase	115,144	AKT	152,155	Phosphatidylinositol 3-Kinase	AKT	5293	207	Gene	Gene	Proliferation|nmod|START_ENTITY Tone|nmod|Proliferation Tone|parataxis|Pathways Pathways|nsubj|END_ENTITY	A Basal Tone of 2-Arachidonoylglycerol Contributes to Early Oligodendrocyte Progenitor Proliferation by Activating Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / AKT and the Mammalian_Target_of_Rapamycin -LRB- MTOR -RRB- Pathways .
14615607	0	Phosphatidylinositol_3-Kinase	102,131	Akt	60,63	Phosphatidylinositol 3-Kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Interference|nmod|Pathway Activity|nmod|Interference Activity|nmod|END_ENTITY	Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol_3-Kinase Signaling Pathway .
25989537	0	Phosphatidylinositol_3-Kinase	110,139	Akt	140,143	Phosphatidylinositol 3-Kinase	Akt	5293	207	Gene	Gene	Leptin|nmod|START_ENTITY Leptin|parataxis|Pathway Pathway|compound|END_ENTITY	Leptin and Neutrophil-Activating_Peptide_2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol_3-Kinase / Akt Pathway in Patients With Systemic Lupus Erythematosus .
26198194	0	Phosphatidylinositol_3-Kinase	0,29	Akt	80,83	Phosphatidylinositol 3-Kinase	Akt	5293	207	Gene	Gene	Influx|compound|START_ENTITY Influx|nmod|END_ENTITY	Phosphatidylinositol_3-Kinase Couples Localised Calcium Influx to Activation of Akt in Central Nerve Terminals .
24304721	0	Phosphatidylinositol_3-Kinase	0,29	epidermal_growth_factor_receptor	60,92	Phosphatidylinositol 3-Kinase	epidermal growth factor receptor	5293	1956	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Phosphatidylinositol_3-Kinase dependent upregulation of the epidermal_growth_factor_receptor upon Flotillin-1 depletion in breast_cancer cells .
26023239	0	Phosphatidylinositol_3-Kinase	22,51	mTOR	91,95	Phosphatidylinositol 3-Kinase	mTOR	5293	21977(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY END_ENTITY|dep|Signaling	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26023239	0	Phosphatidylinositol_3-Kinase	22,51	mTOR	91,95	Phosphatidylinositol 3-Kinase	mTOR	5293	21977(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY END_ENTITY|dep|Signaling	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
11859074	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|signaling signaling|compound|END_ENTITY	Phosphatidylinositol_3-kinase / Akt signaling is neither required for hypoxic stabilization of HIF-1_alpha nor sufficient for HIF-1-dependent target gene transcription .
12167664	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt pathway regulates tuberous_sclerosis_tumor suppressor complex by phosphorylation of tuberin .
12183424	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt signaling in the response of vascular endothelium to ionizing radiation .
16309568	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt pathway mediates heme_oxygenase-1 regulation by lipopolysaccharide .
16310342	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|END_ENTITY	Phosphatidylinositol_3-kinase / Akt pathway is involved in transforming_growth_factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells .
16514645	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt plays a role in sphingosine_1-phosphate-stimulated HSP27 induction in osteoblasts .
16817229	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|auto-regulates auto-regulates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt auto-regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts .
17172275	0	Phosphatidylinositol_3-kinase	0,29	Akt	45,48	Phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / protein kinase Akt negatively regulates plasminogen_activator_inhibitor_type_1 expression in vascular endothelial cells .
18777595	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt pathway regulates hepatic stellate cell apoptosis .
20088406	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	5294	207	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells .
22967108	0	Phosphatidylinositol_3-kinase	0,29	Akt	147,150	Phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|acl:relcl|involve involve|dobj|activation activation|nmod|END_ENTITY	Phosphatidylinositol_3-kinase is an upstream regulator of the phosphodiesterase_3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus .
26192967	0	Phosphatidylinositol_3-kinase	0,29	Akt	30,33	Phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt signaling as a key mediator of tumor cell responsiveness to radiation .
9820515	0	Phosphatidylinositol_3-kinase	0,29	CD28	46,50	Phosphatidylinositol 3-kinase	CD28	5293	940	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Phosphatidylinositol_3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK : functional and physical interaction of EMT with phosphatidylinositol_3-kinase .
15385613	0	Phosphatidylinositol_3-kinase	0,29	ERK	40,43	Phosphatidylinositol 3-kinase	ERK	298947(Tax:10116)	24338(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Phosphatidylinositol_3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat_hyperalgesia through TRPV1 sensitization .
22767591	0	Phosphatidylinositol_3-kinase	0,29	PI3K	31,35	Phosphatidylinositol 3-kinase	PI3K	5293	5293	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Phosphatidylinositol_3-kinase -LRB- PI3K -RRB- activity bound to insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ receptor , which is continuously sustained by IGF-I stimulation , is required for IGF-I-induced cell proliferation .
12882964	0	Phosphatidylinositol_3-kinase	0,29	Reelin	85,91	Phosphatidylinositol 3-kinase	Reelin	5295	5649	Gene	Gene	interacts|amod|START_ENTITY Dab1|nsubj|interacts Dab1|nmod|signaling signaling|compound|END_ENTITY	Phosphatidylinositol_3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination .
16114097	0	Phosphatidylinositol_3-kinase	0,29	cyclin_D2	80,89	Phosphatidylinositol 3-kinase	cyclin D2	18708(Tax:10090)	12444(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Phosphatidylinositol_3-kinase is required for the transcriptional activation of cyclin_D2 in BCR activated primary mouse B lymphocytes .
19874421	0	Phosphatidylinositol_3-kinase	0,29	glucocorticoid_receptor	49,72	Phosphatidylinositol 3-kinase	glucocorticoid receptor	5295	2908	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Phosphatidylinositol_3-kinase interacts with the glucocorticoid_receptor upon TLR2 activation .
21847581	0	Phosphatidylinositol_3-kinase	0,29	inducible_nitric_oxide_synthase	51,82	Phosphatidylinositol 3-kinase	inducible nitric oxide synthase	298947(Tax:10116)	24599(Tax:10116)	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Phosphatidylinositol_3-kinase inhibitor suppresses inducible_nitric_oxide_synthase expression in bronchiole epithelial cells in asthmatic rats .
25900365	0	Phosphatidylinositol_3-kinase	0,29	insulin-like-growth_factor_binding_protein-2	58,102	Phosphatidylinositol 3-kinase	insulin-like-growth factor binding protein-2	5293	3485	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Phosphatidylinositol_3-kinase -LRB- PI3K -RRB- signalling regulates insulin-like-growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- production in human adipocytes .
11679587	0	Phosphatidylinositol_3-kinase	0,29	p85	30,33	Phosphatidylinositol 3-kinase	p85	5293	5296	Gene	Gene	adaptor|amod|START_ENTITY adaptor|amod|END_ENTITY	Phosphatidylinositol_3-kinase p85 adaptor function in T-cells .
12612059	0	Phosphatidylinositol_3-kinase	0,29	vascular_endothelial_growth_factor	96,130	Phosphatidylinositol 3-kinase	vascular endothelial growth factor	5293	7422	Gene	Gene	START_ENTITY|dep|synthesis synthesis|compound|END_ENTITY	Phosphatidylinositol_3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular_endothelial_growth_factor synthesis in prostate epithelial cells : a role for hypoxia-inducible factor-1 ?
19819979	0	Phosphatidylinositol_3_kinase	0,29	Akt	30,33	Phosphatidylinositol 3 kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signal signal|nsubj|END_ENTITY	Phosphatidylinositol_3_kinase / Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony_stimulating_factor-1 -LRB- CSF-1 -RRB- expression and osteoclast differentiation .
25750298	0	Phosphatidylserine-specific_Phospholipase_A1	0,44	PS-PLA1	46,53	Phosphatidylserine-specific Phospholipase A1	PS-PLA1	51365	51365	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Phosphatidylserine-specific_Phospholipase_A1 -LRB- PS-PLA1 -RRB- Expression in Colorectal_Cancer Correlates with Tumor Invasion and Hematogenous_Metastasis .
25342322	0	Phosphatidylserine_Receptor	71,98	Interferon_Regulatory_Factor-1	0,30	Phosphatidylserine Receptor	Interferon Regulatory Factor-1	23210	3659	Gene	Gene	Induction|nmod|START_ENTITY Involved|nmod|Induction Involved|nsubj|END_ENTITY	Interferon_Regulatory_Factor-1 -LRB- IRF-1 -RRB- Is Involved in the Induction of Phosphatidylserine_Receptor -LRB- PSR -RRB- in Response to dsRNA Virus Infection and Contributes to Apoptotic Cell Clearance in CHSE-214 Cell .
25384088	0	Phosphodiesterase_10A	167,188	PDE10A	190,196	Phosphodiesterase 10A	PDE10A	23984(Tax:10090)	23984(Tax:10090)	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|END_ENTITY	Discovery of 1 - -LSB- 2-Fluoro-4 - -LRB- 1H-pyrazol-1-yl -RRB- phenyl -RSB- -5 - methoxy-3 - -LRB- 1-phenyl-1H-pyrazol-5-yl -RRB- pyridazin-4 -LRB- 1H -RRB- - one -LRB- TAK-063 -RRB- , a Highly Potent , Selective , and Orally Active Phosphodiesterase_10A -LRB- PDE10A -RRB- Inhibitor .
25495129	0	Phosphodiesterase_10A	46,67	PDE10A	69,75	Phosphodiesterase 10A	PDE10A	10846	10846	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|END_ENTITY	Identification of a Novel Orally Bioavailable Phosphodiesterase_10A -LRB- PDE10A -RRB- Inhibitor with Efficacy in Animal Models of Schizophrenia .
26055709	0	Phosphodiesterase_12	12,32	PDE12	34,39	Phosphodiesterase 12	PDE12	201626	201626	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Phosphodiesterase_12 -LRB- PDE12 -RRB- as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors .
25815146	0	Phosphodiesterase_2	75,94	PDE2	96,100	Phosphodiesterase 2	PDE2	81743(Tax:10116)	81743(Tax:10116)	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Pyrido -LSB- 4,3-e -RSB- -LSB- 1,2,4 -RSB- triazolo -LSB- 4,3-a -RSB- pyrazines as Selective , Brain Penetrant Phosphodiesterase_2 -LRB- PDE2 -RRB- Inhibitors .
21342916	0	Phosphodiesterase_4	0,19	PDE4	21,25	Phosphodiesterase 4	PDE4	5141	5141	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Phosphodiesterase_4 -LRB- PDE4 -RRB- regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane .
18593531	0	Phosphodiesterase_4B	84,104	PDE4B	106,111	Phosphodiesterase 4B	PDE4B	5142	5142	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Minimizing a QTL region for intramuscular fat content by characterizing the porcine Phosphodiesterase_4B -LRB- PDE4B -RRB- gene .
22426465	0	Phosphodiesterase_type_5	0,24	PDE5	26,30	Phosphodiesterase type 5	PDE5	8654	8654	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Phosphodiesterase_type_5 -LRB- PDE5 -RRB- inhibition improves object recognition memory : indications for central and peripheral mechanisms .
25999794	0	Phosphoenolpyruvate_Carboxykinase	13,46	PEPCK	48,53	Phosphoenolpyruvate Carboxykinase	PEPCK	378727(Tax:7955)	378727(Tax:7955)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of Phosphoenolpyruvate_Carboxykinase -LRB- PEPCK -RRB- during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes .
19801670	0	Phosphoglucose_isomerase	0,24	autocrine_motility_factor	25,50	Phosphoglucose isomerase	autocrine motility factor	2821	2821	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Phosphoglucose_isomerase / autocrine_motility_factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8 .
26855187	0	Phosphoinositide_3-Kinase	129,154	AKT	41,44	Phosphoinositide 3-Kinase	AKT	18708(Tax:10090)	207	Gene	Gene	Subunits|compound|START_ENTITY Expression|nmod|Subunits END_ENTITY|nmod|Expression	C-Type_Lectin-Like_Receptor_2 Suppresses AKT Signaling and Invasive Activities of Gastric_Cancer Cells by Blocking Expression of Phosphoinositide_3-Kinase Subunits .
26101222	0	Phosphoinositide_3-Kinase	23,48	Mammalian_Target_of_Rapamycin	56,85	Phosphoinositide 3-Kinase	Mammalian Target of Rapamycin	5293	2475	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|Sensitizes Sensitizes|nsubj|END_ENTITY	Targeted Inhibition of Phosphoinositide_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Sensitizes Pancreatic_Cancer Cells to Doxorubicin without Exacerbating Cardiac_Toxicity .
26271513	0	Phosphoinositide_3-Kinase-C2a	0,29	Polycystin-2	40,52	Phosphoinositide 3-Kinase-C2a	Polycystin-2	18704(Tax:10090)	18764(Tax:10090)	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	Phosphoinositide_3-Kinase-C2a Regulates Polycystin-2 Ciliary Entry and Protects against Kidney_Cyst Formation .
16036919	0	Phosphoinositide_3-kinase	0,25	Akt	39,42	Phosphoinositide 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Phosphoinositide_3-kinase signaling to Akt promotes keratinocyte differentiation versus death .
16115127	0	Phosphoinositide_3-kinase	0,25	Akt	26,29	Phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|increases increases|nsubj|inhibition inhibition|compound|END_ENTITY	Phosphoinositide_3-kinase / Akt inhibition increases arsenic_trioxide-induced apoptosis of acute promyelocytic and T-cell_leukaemias .
16642045	0	Phosphoinositide_3-kinase	0,25	Akt	26,29	Phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Phosphoinositide_3-kinase / Akt signaling pathway and its therapeutical implications for human acute_myeloid_leukemia .
17935137	0	Phosphoinositide_3-kinase	0,25	Akt	26,29	Phosphoinositide 3-kinase	Akt	5295	207	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	Phosphoinositide_3-kinase / Akt pathway plays an important role in chemoresistance of gastric_cancer cells against etoposide and doxorubicin induced cell death .
19051078	0	Phosphoinositide_3-kinase	0,25	Akt	26,29	Phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|responsible responsible|nsubj|signalling signalling|compound|END_ENTITY	Phosphoinositide_3-kinase / Akt signalling is responsible for the differential susceptibility of myoblasts and myotubes to menadione-induced oxidative stress .
21472268	0	Phosphoinositide_3-kinase	0,25	Akt	26,29	Phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|END_ENTITY	Phosphoinositide_3-kinase / Akt and nuclear factor kB pathways are involved in tumor_necrosis_factor-related_apoptosis-inducing_ligand resistance in human gastric_cancer cells .
23206708	0	Phosphoinositide_3-kinase	0,25	Akt	26,29	Phosphoinositide 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|essential essential|nsubj|signaling signaling|compound|END_ENTITY	Phosphoinositide_3-kinase / Akt signaling is essential for prostaglandin_E2-induced osteogenic differentiation of rat tendon stem cells .
23859135	0	Phosphoinositide_3-kinase	0,25	Akt	26,29	Phosphoinositide 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|involved involved|nsubjpass|END_ENTITY	Phosphoinositide_3-kinase / Akt pathway is involved in mediating the anti-inflammation effects of magnesium_sulfate .
25800443	0	Phosphoinositide_3-kinase	97,122	Akt	123,126	Phosphoinositide 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	Inflammation|nmod|START_ENTITY Inflammation|dep|Pathway Pathway|compound|END_ENTITY	Maternal Disononyl_Phthalate Exposure Activates Allergic Airway Inflammation via Stimulating the Phosphoinositide_3-kinase / Akt Pathway in Rat Pups .
12459553	0	Phosphoinositide_3-kinase	0,25	Igbeta	40,46	Phosphoinositide 3-kinase	Igbeta	5293	974	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Phosphoinositide_3-kinase activation by Igbeta controls de novo formation of an antigen-processing compartment .
17586693	0	Phosphoinositide_3-kinase	0,25	MUC1	42,46	Phosphoinositide 3-kinase	MUC1	5295	4582	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Phosphoinositide_3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like_receptor_5 signaling .
19133120	0	Phosphoinositide_3-kinase	0,25	akt	93,96	Phosphoinositide 3-kinase	akt	5293	207	Gene	Gene	negates|nsubj|START_ENTITY negates|dobj|expression expression|amod|END_ENTITY	Phosphoinositide_3-kinase targeting by the beta galactoside binding protein cytokine negates akt gene expression and leads aggressive breast_cancer cells to apoptotic death .
18780892	0	Phosphoinositide_3-kinase	0,25	p110beta	26,34	Phosphoinositide 3-kinase	p110beta	18708(Tax:10090)	74769(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Phosphoinositide_3-kinase p110beta activity : key role in metabolism and mammary gland cancer but not development .
17241641	0	Phospholamban	0,13	HAX-1	29,34	Phospholamban	HAX-1	5350	10456	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Phospholamban interacts with HAX-1 , a mitochondrial protein with anti-apoptotic function .
12169672	0	Phospholemman	0,13	Na,K-ATPase	38,49	Phospholemman	Na,K-ATPase	444822(Tax:8355)	398583(Tax:8355)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Phospholemman -LRB- FXYD1 -RRB- associates with Na,K-ATPase and regulates its transport properties .
25725101	0	Phospholipase_A2	17,33	IL-4	52,56	Phospholipase A2	IL-4	151056	3565	Gene	Gene	Upregulated|nsubjpass|START_ENTITY Upregulated|nmod|END_ENTITY	Group V Secreted Phospholipase_A2 Is Upregulated by IL-4 in Human Macrophages and Mediates Phagocytosis via Hydrolysis of Ethanolamine Phospholipids .
10421488	0	Phospholipase_A2	0,16	PLA2	18,22	Phospholipase A2	PLA2	445525(Tax:9823)	445525(Tax:9823)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Phospholipase_A2 -LRB- PLA2 -RRB- activity in mini pigs after acute high dose i.v.-paraoxon -LRB- POX -RRB- intoxication .
1793014	0	Phospholipase_A2	0,16	PLA2	18,22	Phospholipase A2	PLA2	104974671	104974671	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Phospholipase_A2 -LRB- PLA2 -RRB- activity in bovine pulmonary artery endothelial cells .
8358004	0	Phospholipase_A2	0,16	PLA2	18,22	Phospholipase A2	PLA2	151056	151056	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Phospholipase_A2 -LRB- PLA2 -RRB- activity in gerbil brain : characterization of cytosolic and membrane-associated forms and effects of ischemia and reperfusion on enzymatic activity .
20354123	0	Phospholipase_A2	0,16	peroxiredoxin_6	29,44	Phospholipase A2	peroxiredoxin 6	151056	9588	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Phospholipase_A2 activity of peroxiredoxin_6 promotes invasion and metastasis of lung_cancer cells .
2121330	0	Phospholipase_A2	0,16	tumor_necrosis_factor	49,70	Phospholipase A2	tumor necrosis factor	151056	7124	Gene	Gene	activation|amod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Phospholipase_A2 activation and autoinduction of tumor_necrosis_factor gene expression by tumor_necrosis_factor .
2121330	0	Phospholipase_A2	0,16	tumor_necrosis_factor	90,111	Phospholipase A2	tumor necrosis factor	151056	7124	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Phospholipase_A2 activation and autoinduction of tumor_necrosis_factor gene expression by tumor_necrosis_factor .
8554585	0	Phospholipase_A2	0,16	tumor_necrosis_factor-alpha	33,60	Phospholipase A2	tumor necrosis factor-alpha	151056	7124	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Phospholipase_A2 is activated by tumor_necrosis_factor-alpha in primary hepatocytes stimulated by a deleted form of hepatocyte growth factor .
7706741	0	Phospholipase_A2-activating_protein	0,35	IL-1_and_TNF	61,73	Phospholipase A2-activating protein	IL-1 and TNF	9373	3553;7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Phospholipase_A2-activating_protein induces the synthesis of IL-1_and_TNF in human monocytes .
25422234	0	Phospholipase_A2_Group_IIA	18,44	Cyclooxygenase-2	104,120	Phospholipase A2 Group IIA	Cyclooxygenase-2	5320	5743	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|Expression Expression|compound|END_ENTITY	Overexpression of Phospholipase_A2_Group_IIA in Esophageal_Squamous_Cell_Carcinoma and Association with Cyclooxygenase-2 Expression .
9704070	0	Phospholipase_B	0,15	phospholipase_A	39,54	Phospholipase B	phospholipase A	151056	57110	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Phospholipase_B activity of a purified phospholipase_A from Vipera palestinae venom .
25981537	0	Phospholipase_C-Related_But_Catalytically_Inactive_Protein	21,79	PRIP	15,19	Phospholipase C-Related But Catalytically Inactive Protein	PRIP	227120(Tax:10090)	227120(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of PRIP -LRB- Phospholipase_C-Related_But_Catalytically_Inactive_Protein -RRB- in BMP-Induced Smad Signaling in Osteoblast Differentiation .
26350460	0	Phospholipase_C-epsilon	120,143	CDC25	83,88	Phospholipase C-epsilon	CDC25	5334	995	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase_C-epsilon .
26350460	0	Phospholipase_C-epsilon	120,143	Thrombin	0,8	Phospholipase C-epsilon	Thrombin	5334	2147	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase_C-epsilon .
8388373	0	Phospholipase_C-gamma_1	0,23	src	59,62	Phospholipase C-gamma 1	src	25738(Tax:10116)	83805(Tax:10116)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Phospholipase_C-gamma_1 associates with viral and cellular src kinases .
26474454	0	Phospholipase_C_gamma_1	0,23	PLCG1	25,30	Phospholipase C gamma 1	PLCG1	5335	5335	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Phospholipase_C_gamma_1 -LRB- PLCG1 -RRB- R707Q mutation is counterselected under targeted therapy in a patient with hepatic_angiosarcoma .
25904324	0	Phospholipase_C_gamma_1	0,23	p115	102,106	Phospholipase C gamma 1	p115	5335	8615	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Phospholipase_C_gamma_1 regulates early secretory trafficking and cell migration via interaction with p115 .
9103240	0	Phospholipase_D	0,15	Fc_gamma_receptor	25,42	Phospholipase D	Fc gamma receptor	2822	2209	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	Phospholipase_D mediates Fc_gamma_receptor activation of neutrophils and provides specificity between high-valency_immune_complexes and fMLP signaling pathways .
20438709	0	Phospholipase_D	0,15	HDM2	27,31	Phospholipase D	HDM2	2822	4193	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Phospholipase_D stabilizes HDM2 through an mTORC2/SGK1 pathway .
10375402	0	Phospholipase_D	0,15	cytochrome_P450	28,43	Phospholipase D	cytochrome P450	2822	4051	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Phospholipase_D activity of cytochrome_P450 in human liver endoplasmic reticulum .
21622984	0	Phospholipase_D	0,15	mammalian_target_of_rapamycin	43,72	Phospholipase D	mammalian target of rapamycin	2822	2475	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Phospholipase_D mediates nutrient input to mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- .
20231899	0	Phospholipase_D1	0,16	AMP-activated_protein_kinase	26,54	Phospholipase D1	AMP-activated protein kinase	5337	5563	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Phospholipase_D1 mediates AMP-activated_protein_kinase signaling for glucose uptake .
12014986	0	Phospholipase_D1	0,16	Src	141,144	Phospholipase D1	Src	5337	6714	Gene	Gene	threonine-phosphorylated|nsubj|START_ENTITY threonine-phosphorylated|nmod|cells cells|acl|stimulated stimulated|nmod|mechanism mechanism|acl|involving involving|dobj|kinase kinase|amod|END_ENTITY	Phospholipase_D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta .
17146759	0	Phospholipase_D1	0,16	Src	36,39	Phospholipase D1	Src	5337	6714	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Phospholipase_D1 activation through Src and Ras is involved in basic_fibroblast_growth_factor-induced neurite outgrowth of H19-7 cells .
22544632	0	Phospholipase_D1	0,16	neurotrophin-3	59,73	Phospholipase D1	neurotrophin-3	25096(Tax:10116)	81737(Tax:10116)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Phospholipase_D1 is an important regulator of bFGF-induced neurotrophin-3 expression and neurite outgrowth in H19-7 cells .
17516241	0	Phospholipid_hydroperoxide_glutathione_peroxidase	0,49	PHGPx	51,56	Phospholipid hydroperoxide glutathione peroxidase	PHGPx	2879	2879	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Phospholipid_hydroperoxide_glutathione_peroxidase -LRB- PHGPx -RRB- expression is downregulated in poorly differentiated breast_invasive_ductal_carcinoma .
23381670	0	Phosphoprotein_Phosphatase	0,26	Insulin_Receptor_Substrate_1	46,74	Phosphoprotein Phosphatase	Insulin Receptor Substrate 1	5504	3667	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Phosphoprotein_Phosphatase PP2A Regulation of Insulin_Receptor_Substrate_1 and Insulin Metabolic Signaling .
7519097	0	Phosrestin_I	0,12	arrestin	17,25	Phosrestin I	arrestin	38993(Tax:7227)	35078(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Phosrestin_I , an arrestin homolog that undergoes light-induced phosphorylation in dipteran photoreceptors .
7910552	0	Phox2	30,35	Cux/CDP	85,92	Phox2	Cux/CDP	11859(Tax:10090)	13047(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype .
7910552	0	Phox2	30,35	Ncam	46,50	Phox2	Ncam	11859(Tax:10090)	17967(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype .
26137098	0	Phox2B	0,6	MYCN	23,27	Phox2B	MYCN	8929	4613	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development .
15106827	0	Phox2a	39,45	Ciliary_neurotrophic_factor	0,27	Phox2a	Ciliary neurotrophic factor	116648(Tax:10116)	25707(Tax:10116)	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	Ciliary_neurotrophic_factor suppresses Phox2a in sympathetic neurons .
10536054	0	Phox2a	31,37	Ret	14,17	Phox2a	Ret	11859(Tax:10090)	19713(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of Ret - , p75 -LRB- NTR -RRB- - , Phox2a - , Phox2b - , and tyrosine_hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut .
16982676	0	Phox2a	33,39	p27Kip1	85,92	Phox2a	p27Kip1	401	1027	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|amod|END_ENTITY	Homeodomain transcription factor Phox2a , via cyclic_AMP-mediated activation , induces p27Kip1 transcription , coordinating neural progenitor cell cycle exit and differentiation .
20156452	0	Phr1	44,48	PHR	14,17	Phr1	PHR	105689(Tax:10090)	104151(Tax:10090)	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	Structures of PHR domains from Mus_musculus Phr1 -LRB- Mycbp2 -RRB- explain the loss-of-function mutation -LRB- Gly1092 -- > Glu -RRB- of the C. _ elegans ortholog RPM-1 .
11069292	0	Phytochrome_B	0,13	PIF3	107,111	Phytochrome B	PIF3	816394(Tax:3702)	837479(Tax:3702)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Phytochrome_B binds with greater apparent affinity than phytochrome A to the basic helix-loop-helix factor PIF3 in a reaction requiring the PAS domain of PIF3 .
11069292	0	Phytochrome_B	0,13	PIF3	154,158	Phytochrome B	PIF3	816394(Tax:3702)	837479(Tax:3702)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|PIF3 PIF3|nmod|reaction reaction|acl|requiring requiring|dobj|domain domain|nmod|END_ENTITY	Phytochrome_B binds with greater apparent affinity than phytochrome A to the basic helix-loop-helix factor PIF3 in a reaction requiring the PAS domain of PIF3 .
7572178	0	Phytolacca_acinosa_polysaccharides_I	11,47	interleukin-2	62,75	Phytolacca acinosa polysaccharides I	interleukin-2	11747(Tax:10090)	16183(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY combined|nsubj|Effects combined|nmod|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I combined with interleukin-2 on the cytotoxicity of murine splenocytes against tumor cells .
15641067	0	PiT-1	25,30	interleukin-8	8,21	PiT-1	interleukin-8	6574	3576	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes .
16098628	0	Pias3	52,57	Stat3	10,15	Pias3	Stat3	10401	6774	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|DNA-binding DNA-binding|compound|END_ENTITY	Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis_C cirrhosis .
9363658	0	Pic1	20,24	p21	0,3	Pic1	p21	7341	1026	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	p21 -LRB- WAF1/Cip1/Sdi1 / Pic1 -RRB- mRNA is expressed in neuroblastoma cell lines but not in Ewing 's _ sarcoma and primitive_neuroectodermal_tumor cell lines .
11679086	0	Pick	54,58	c-MYC	15,20	Pick	c-MYC	9463	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Phosphorylated c-MYC expression in Alzheimer_disease , Pick 's _ disease , progressive_supranuclear_palsy and corticobasal_degeneration .
10973264	0	Pidd	0,4	p53	59,62	Pidd	p53	57913(Tax:10090)	22059(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Pidd , a new death-domain-containing protein , is induced by p53 and promotes apoptosis .
11154263	0	Pie1	0,4	Mec1	33,37	Pie1	Mec1	852110(Tax:4932)	852433(Tax:4932)	Gene	Gene	START_ENTITY|appos|protein protein|acl|interacting interacting|nmod|END_ENTITY	Pie1 , a protein interacting with Mec1 , controls cell growth and checkpoint responses in Saccharomyces_cerevisiae .
17827721	0	Pif1	48,52	helicase	53,61	Pif1	helicase	80119	164045	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Mitochondrial and nuclear localization of human Pif1 helicase .
20524933	0	Pif1	6,10	helicase	11,19	Pif1	helicase	80119	164045	Gene	Gene	protein|nsubj|START_ENTITY protein|advmod|END_ENTITY	Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity .
25471447	0	Pif1	111,115	helicase	46,54	Pif1	helicase	80119	164045	Gene	Gene	helicase|amod|START_ENTITY G-quadruplex|nmod|helicase sequential|nmod|G-quadruplex mechanism|dep|sequential mechanism|nmod|END_ENTITY	Molecular mechanism of G-quadruplex unwinding helicase : sequential and repetitive unfolding of G-quadruplex by Pif1 helicase .
10574991	0	Pig-n	0,5	Mcd4p	38,43	Pig-n	Mcd4p	23556	853690(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Pig-n , a mammalian homologue of yeast Mcd4p , is involved in transferring phosphoethanolamine to the first mannose of the glycosylphosphatidylinositol .
26751204	0	Pigment_Epithelium-Derived_Factor	12,45	PEDF	47,51	Pigment Epithelium-Derived Factor	PEDF	57104	57104	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Correction : Pigment_Epithelium-Derived_Factor -LRB- PEDF -RRB- Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells .
21508362	0	Pigment_epithelial-derived_factor	0,33	c-FLIP	43,49	Pigment epithelial-derived factor	c-FLIP	5176	8837	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Pigment_epithelial-derived_factor inhibits c-FLIP expression and assists ciglitazone-induced apoptosis in hepatocellular_carcinoma .
15713745	0	Pigment_epithelium-derived_factor	0,33	Fyn	131,134	Pigment epithelium-derived factor	Fyn	57104	2534	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Pigment_epithelium-derived_factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn .
15739190	0	Pigment_epithelium-derived_factor	0,33	NF-kappa_B	110,120	Pigment epithelium-derived factor	NF-kappa B	57104	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Pigment_epithelium-derived_factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-kappa_B and CREB .
20553736	0	Pigment_epithelium-derived_factor	0,33	PPAR_gamma	105,115	Pigment epithelium-derived factor	PPAR gamma	57104	5468	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	Pigment_epithelium-derived_factor induces interleukin-10 expression in human macrophages by induction of PPAR_gamma .
16901919	0	Pigment_epithelium-derived_factor	0,33	VEGF	84,88	Pigment epithelium-derived factor	VEGF	287526(Tax:10116)	83785(Tax:10116)	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Pigment_epithelium-derived_factor downregulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and inhibits VEGF-VEGF receptor 2 binding in diabetic_retinopathy .
21617872	0	Pigment_epithelium-derived_factor	0,33	VEGF	110,114	Pigment epithelium-derived factor	VEGF	57104	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	Pigment_epithelium-derived_factor inhibits angiogenesis and growth of gastric_carcinoma by down-regulation of VEGF .
25700221	0	Pigment_epithelium-derived_factor	0,33	adipose_triglyceride_lipase	79,106	Pigment epithelium-derived factor	adipose triglyceride lipase	57104	57104	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Pigment_epithelium-derived_factor regulates microvascular permeability through adipose_triglyceride_lipase in sepsis .
24161393	0	Pigment_epithelium-derived_factor	0,33	caveolin-1	50,60	Pigment epithelium-derived factor	caveolin-1	57104	857	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells .
20553736	0	Pigment_epithelium-derived_factor	0,33	interleukin-10	42,56	Pigment epithelium-derived factor	interleukin-10	57104	3586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Pigment_epithelium-derived_factor induces interleukin-10 expression in human macrophages by induction of PPAR_gamma .
15276019	0	Pigment_epithelium-derived_factor	0,33	interleukin-6	61,74	Pigment epithelium-derived factor	interleukin-6	57104	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Pigment_epithelium-derived_factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation .
26622904	0	Pigment_epithelium-derived_factor	0,33	interleukin-8	60,73	Pigment epithelium-derived factor	interleukin-8	57104	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Pigment_epithelium-derived_factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate_cancer cells .
17870167	0	Pigment_epithelium-derived_factor	0,33	peroxisome_proliferator-activated_receptor_gamma	106,154	Pigment epithelium-derived factor	peroxisome proliferator-activated receptor gamma	57104	5468	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	Pigment_epithelium-derived_factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome_proliferator-activated_receptor_gamma .
12711260	0	Pigment_epithelium-derived_factor	0,33	vascular_endothelial_growth_factor	86,120	Pigment epithelium-derived factor	vascular endothelial growth factor	57104	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	Pigment_epithelium-derived_factor inhibits leptin-induced angiogenesis by suppressing vascular_endothelial_growth_factor gene expression through anti-oxidative properties .
15985268	0	Pigment_epithelium-derived_factor	0,33	vascular_endothelial_growth_factor	77,111	Pigment epithelium-derived factor	vascular endothelial growth factor	57104	7422	Gene	Gene	START_ENTITY|dep|apoptosis apoptosis|nmod|expression expression|amod|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16707486	0	Pigment_epithelium-derived_factor	0,33	vascular_endothelial_growth_factor	162,196	Pigment epithelium-derived factor	vascular endothelial growth factor	287526(Tax:10116)	83785(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|blocking blocking|dobj|expression expression|compound|END_ENTITY	Pigment_epithelium-derived_factor inhibits advanced glycation end product-induced retinal_vascular_hyperpermeability by blocking reactive oxygen species-mediated vascular_endothelial_growth_factor expression .
27053109	0	Pih1	71,75	Rpn8	23,27	Pih1	Rpn8	856429(Tax:4932)	854435(Tax:4932)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	The Proteasome Subunit Rpn8 Interacts with the snoRNP Assembly Protein Pih1 and Mediates its Ubiquitin-Independent Degradation in Saccharomyces_cerevisiae .
16356754	0	Pim-1	38,43	Cdc25C	112,118	Pim-1	Cdc25C	5292	995	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C .
11237709	0	Pim-1	14,19	Hsp90	23,28	Pim-1	Hsp90	5292	3320	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Pim-1 by Hsp90 .
19911008	0	Pim-1	0,5	NF-kappaB	15,24	Pim-1	NF-kappaB	5292	4790	Gene	Gene	controls|amod|START_ENTITY END_ENTITY|nsubj|controls	Pim-1 controls NF-kappaB signalling by stabilizing RelA/p65 .
26508734	0	Pim-1	32,37	TNF-a	18,23	Pim-1	TNF-a	5292	7124	Gene	Gene	Isoforms|compound|START_ENTITY Isoforms|compound|END_ENTITY	Smac Mimetic with TNF-a Targets Pim-1 Isoforms and Reactive Oxygen Species Production to Abrogate Transformation from Blebbishields .
21743487	0	Pim-1	19,24	miR-33a	40,47	Pim-1	miR-33a	5292	407039	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The proto-oncogene Pim-1 is a target of miR-33a .
20307683	0	Pim-2	0,5	p21	25,28	Pim-2	p21	11040	1026	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pim-2 phosphorylation of p21 -LRB- Cip1/WAF1 -RRB- enhances its stability and inhibits cell proliferation in HCT116 cells .
23845873	0	Pim-3	0,5	vascular_endothelium_growth_factor	96,130	Pim-3	vascular endothelium growth factor	415116	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Pim-3 promotes the growth of human pancreatic_cancer in the orthotopic nude mouse model through vascular_endothelium_growth_factor .
17327400	0	Pim1	18,22	HOXA9	57,62	Pim1	HOXA9	5292	3205	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	Evidence that the Pim1 kinase gene is a direct target of HOXA9 .
17606638	0	Pimet	0,5	HEN1	33,37	Pimet	HEN1	36301(Tax:7227)	36301(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Pimet , the Drosophila homolog of HEN1 , mediates 2 ' - O-methylation of Piwi - interacting RNAs at their 3 ' ends .
19367327	0	Pin-1	32,37	Protein_kinase-X	0,16	Pin-1	Protein kinase-X	23988(Tax:10090)	19108(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protein_kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development .
20569234	0	Pin1	17,21	BTG2	0,4	Pin1	BTG2	5300	7832	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence .
16644721	0	Pin1	69,73	Bruton_tyrosine_kinase	14,36	Pin1	Bruton tyrosine kinase	5300	695	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Bruton_tyrosine_kinase by the peptidylprolyl isomerase Pin1 .
23390529	0	Pin1	21,25	CDK2	52,56	Pin1	CDK2	5300	1017	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen_receptor_a in breast_cancer .
24265246	0	Pin1	36,40	COT	0,3	Pin1	COT	5300	1326	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast_cancer .
19638580	0	Pin1	30,34	Cep55	65,70	Pin1	Cep55	5300	55165	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55 .
12792768	0	Pin1	71,75	Cyclin_D1	92,101	Pin1	Cyclin D1	5300	595	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|expression expression|amod|END_ENTITY	Expression status of Pin1 and cyclins in oral_squamous_cell_carcinoma : Pin1 correlates with Cyclin_D1 mRNA expression and clinical significance of cyclins .
21497122	0	Pin1	49,53	Death-associated_protein_kinase_1	0,33	Pin1	Death-associated protein kinase 1	5300	1612	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Death-associated_protein_kinase_1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function .
17159919	0	Pin1	0,4	Emi1	16,20	Pin1	Emi1	5300	26271	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF -LRB- betatrcp -RRB- .
11904169	0	Pin1	0,4	Fcp1	89,93	Pin1	Fcp1	853475(Tax:4932)	855320(Tax:4932)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1 .
20179161	0	Pin1	21,25	HER-2	35,40	Pin1	HER-2	5300	2064	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	The prolyl isomerase Pin1 enhances HER-2 expression and cellular transformation via its interaction with mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1 .
11787050	0	Pin1	14,18	IGF-1	0,5	Pin1	IGF-1	5300	3479	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IGF-1 induces Pin1 expression in promoting cell cycle S-phase entry .
20479004	0	Pin1	21,25	LC-3	34,38	Pin1	LC-3	5300	84557	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast_cancer .
22566623	0	Pin1	55,59	Mixed-lineage_kinase_3	0,22	Pin1	Mixed-lineage kinase 3	5300	4296	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Mixed-lineage_kinase_3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function .
26943576	0	Pin1	0,4	Myc	81,84	Pin1	Myc	23988(Tax:10090)	17869(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc .
19668231	0	Pin1	21,25	NF-kappaB	40,49	Pin1	NF-kappaB	5300	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma .
19151708	0	Pin1	21,25	Notch1	31,37	Pin1	Notch1	5300	4851	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer .
25463757	0	Pin1	17,21	Osterix	59,66	Pin1	Osterix	5300	121340	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix .
22580604	0	Pin1	17,21	RUNX3	53,58	Pin1	RUNX3	5300	864	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast_cancer .
23750710	0	Pin1	18,22	STAT3	27,32	Pin1	STAT3	23988(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signalling signalling|compound|END_ENTITY	Essential role of Pin1 via STAT3 signalling and mitochondria-dependent pathways in restenosis in type 2 diabetes .
24530597	0	Pin1	0,4	TGF-b1	54,60	Pin1	TGF-b1	23988(Tax:10090)	21803(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Pin1 induction in the fibrotic liver and its roles in TGF-b1 expression and Smad2/3 phosphorylation .
18188456	0	Pin1	0,4	TGF-beta1	15,24	Pin1	TGF-beta1	5300	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic_lung_fibrosis .
22002310	0	Pin1	17,21	TR3	71,74	Pin1	TR3	5300	3164	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis .
11533658	0	Pin1	0,4	beta-catenin	56,68	Pin1	beta-catenin	5300	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC .
18359295	0	Pin1	0,4	c-Myb	20,25	Pin1	c-Myb	5300	4602	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity .
23362255	0	Pin1	10,14	cyclin-dependent_kinase	62,85	Pin1	cyclin-dependent kinase	5300	1020	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent_kinase -LRB- Cdk5 -RRB- - dependent Alzheimer phosphorylation sites .
17082615	0	Pin1	30,34	granulocyte-macrophage_colony-stimulating_factor	45,93	Pin1	granulocyte-macrophage colony-stimulating factor	5300	1437	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage_colony-stimulating_factor mRNA stability in T lymphocytes .
11575923	0	Pin1	30,34	hSpt5	50,55	Pin1	hSpt5	5300	6829	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9 .
20307651	0	Pin1	102,106	heme_oxygenase-1	71,87	Pin1	heme oxygenase-1	23988(Tax:10090)	15368(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Role of Pin1 in neointima formation : down-regulation of Nrf2-dependent heme_oxygenase-1 expression by Pin1 .
20307651	0	Pin1	8,12	heme_oxygenase-1	71,87	Pin1	heme oxygenase-1	23988(Tax:10090)	15368(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	Role of Pin1 in neointima formation : down-regulation of Nrf2-dependent heme_oxygenase-1 expression by Pin1 .
24786790	0	Pin1	17,21	miR200c	41,48	Pin1	miR200c	5300	406985	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast_cancer .
19584057	0	Pin1	0,4	p27Kip1	52,59	Pin1	p27Kip1	23988(Tax:10090)	12576(Tax:10090)	Gene	Gene	catalyzes|nsubj|START_ENTITY catalyzes|dobj|changes changes|nmod|Thr-187 Thr-187|nmod|END_ENTITY	Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process .
18794148	0	Pin1	23,27	p27kip1	38,45	Pin1	p27kip1	5300	1027	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors .
12388558	0	Pin1	8,12	p53	34,37	Pin1	p53	5300	7157	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|stability stability|compound|END_ENTITY	Role of Pin1 in the regulation of p53 stability and p21 transactivation , and cell cycle checkpoints in response to DNA damage .
12397361	0	Pin1	21,25	p53	44,47	Pin1	p53	5300	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response .
12397362	0	Pin1	21,25	p53	57,60	Pin1	p53	5300	7157	Gene	Gene	reveals|nsubj|START_ENTITY reveals|dobj|mechanism mechanism|acl|control control|dobj|functions functions|compound|END_ENTITY	The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults .
15893113	0	Pin1	28,32	p53	0,3	Pin1	p53	5300	7157	Gene	Gene	activated|nmod|START_ENTITY activated|nsubj|Protein Protein|compound|END_ENTITY	p53 Protein is activated by Pin1 : and also by Cu-SOD prion-like enzyme .
15964795	0	Pin1	56,60	p53	27,30	Pin1	p53	5300	7157	Gene	Gene	impair|nmod|START_ENTITY impair|nsubj|Mutations Mutations|nmod|proline proline|nmod|END_ENTITY	Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage .
17906639	0	Pin1	21,25	p53	39,42	Pin1	p53	5300	7157	Gene	Gene	orchestrates|nsubj|START_ENTITY orchestrates|dobj|acetylation acetylation|compound|END_ENTITY	The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP .
21926448	0	Pin1	32,36	p53	54,57	Pin1	p53	5300	7157	Gene	Gene	unleashes|nsubj|START_ENTITY unleashes|dobj|END_ENTITY	Wiring the oncogenic circuitry : Pin1 unleashes mutant p53 .
22017796	0	Pin1	26,30	p53	47,50	Pin1	p53	5300	7157	Gene	Gene	empowers|nsubj|START_ENTITY empowers|dobj|END_ENTITY	The amplifier effect : how Pin1 empowers mutant p53 .
22935610	0	Pin1	21,25	p53	71,74	Pin1	p53	5300	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|program program|nmod|END_ENTITY	The prolyl-isomerase Pin1 activates the mitochondrial death program of p53 .
25451271	0	Pin1	25,29	p53	0,3	Pin1	p53	5300	7157	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p53 negatively regulates Pin1 expression under ER stress .
19770518	0	Pin1	0,4	parathyroid_hormone	15,34	Pin1	parathyroid hormone	23988(Tax:10090)	19226(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Pin1 regulates parathyroid_hormone mRNA stability .
23407864	0	Pin1	35,39	peptidyl-prolyl_isomerase	40,65	Pin1	peptidyl-prolyl isomerase	5300	51645	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	Non-catalytic participation of the Pin1 peptidyl-prolyl_isomerase domain in target binding .
19996102	0	Pin1	28,32	peroxisome_proliferator-activated_receptor_gamma	43,91	Pin1	peroxisome proliferator-activated receptor gamma	5300	5468	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Proline cis/trans-isomerase Pin1 regulates peroxisome_proliferator-activated_receptor_gamma activity through the direct binding to the activation function-1 domain .
22907757	0	Pin1	21,25	stem-loop_binding_protein	34,59	Pin1	stem-loop binding protein	5300	7884	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	The prolyl isomerase Pin1 targets stem-loop_binding_protein -LRB- SLBP -RRB- to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination .
19439498	0	Pin1	91,95	sulfotransferase_4A1	15,35	Pin1	sulfotransferase 4A1	5300	25830	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cytosolic Aryl sulfotransferase_4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1 .
18294451	0	Pin1	77,81	vascular_endothelial_growth_factor	13,47	Pin1	vascular endothelial growth factor	5300	7422	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by peptidyl-prolyl isomerase Pin1 in breast_cancer cells .
19393617	0	PinX1	0,5	Nucleolin	58,67	PinX1	Nucleolin	54984	4691	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	PinX1 is recruited to the mitotic chromosome periphery by Nucleolin and facilitates chromosome congression .
12011113	0	Pincher	0,7	TrkA	55,59	Pincher	TrkA	192204(Tax:10116)	59109(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Pincher , a pinocytic_chaperone for nerve_growth_factor / TrkA signaling endosomes .
26538564	0	Pink1	28,33	Bag2	0,4	Pink1	Bag2	65018	9532	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Bag2 Mediated Regulation of Pink1 is Critical for Mitochondrial Translocation of Parkin and Neuronal Survival .
19570914	0	Pins	26,30	Galpha	46,52	Pins	Galpha	53569(Tax:7227)	36384(Tax:7227)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Drosophila GoLoco-protein Pins is a target of Galpha -LRB- o -RRB- - mediated G protein-coupled receptor signaling .
9671474	0	Pip	21,24	E47	52,55	Pip	E47	5304	6929	Gene	Gene	enhance|nsubj|START_ENTITY enhance|nmod|END_ENTITY	Transcription factor Pip can enhance DNA binding by E47 , leading to transcriptional synergy involving multiple protein domains .
21236467	0	Pirh2	14,19	Kip1	101,105	Pirh2	Kip1	25898	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	Pirh2	14,19	Kip1	27,31	Pirh2	Kip1	25898	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|ligase ligase|appos|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
22570270	0	Pirh2	72,77	SCYL1_binding_protein_1	0,23	Pirh2	SCYL1 binding protein 1	68098(Tax:10090)	98376(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	SCYL1_binding_protein_1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular_carcinoma .
21236467	0	Pirh2	14,19	p27	23,26	Pirh2	p27	25898	3429	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|ligase ligase|amod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	Pirh2	14,19	p27	97,100	Pirh2	p27	25898	3429	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|Kip1 Kip1|amod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
18006823	0	Pirh2	0,5	p27Kip1	88,95	Pirh2	p27Kip1	25898	1027	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1 .
21994467	0	Pirh2	0,5	p73	39,42	Pirh2	p73	68098(Tax:10090)	22062(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Pirh2 , a ubiquitin E3 ligase , inhibits p73 transcriptional activity by promoting its ubiquitination .
23863968	0	Pirt	0,4	TRPM8	45,50	Pirt	TRPM8	193003(Tax:10090)	171382(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Pirt functions as an endogenous regulator of TRPM8 .
26657057	0	Pirt	47,51	TRPM8	62,67	Pirt	TRPM8	644139	79054	Gene	Gene	regulator|appos|START_ENTITY enhances|nsubj|regulator enhances|dobj|activity activity|compound|END_ENTITY	Phosphoinositide interacting regulator of TRP -LRB- Pirt -RRB- enhances TRPM8 channel activity in vitro via increasing channel conductance .
21655234	0	Pirt	0,4	itch	78,82	Pirt	itch	193003(Tax:10090)	16396(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Pirt , a TRPV1 modulator , is required for histamine-dependent and - independent itch .
26151598	0	Pirt	0,4	purinergic_receptor_P2X3	48,72	Pirt	purinergic receptor P2X3	193003(Tax:10090)	228139(Tax:10090)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Pirt reduces bladder_overactivity by inhibiting purinergic_receptor_P2X3 .
25992773	0	Pit-1	0,5	BRCA1	15,20	Pit-1	BRCA1	5449	672	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pit-1 inhibits BRCA1 and sensitizes human breast_tumors to cisplatin and vitamin_D treatment .
17933456	0	Pit-1	79,84	Brn-5	21,26	Pit-1	Brn-5	5449	5463	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of mPOU -LRB- Brn-5 -RRB- , a class VI POU protein , in the gene expression of Pit-1 as well as PRL .
8798730	0	Pit-1	6,11	GHF-1	0,5	Pit-1	GHF-1	25517(Tax:10116)	25517(Tax:10116)	Gene	Gene	functions|compound|START_ENTITY END_ENTITY|dep|functions	GHF-1 / Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1 / GHF-1 response element .
9275086	0	Pit-1	107,112	Growth_hormone	0,14	Pit-1	Growth hormone	18736(Tax:10090)	14599(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|expression expression|amod|END_ENTITY	Growth_hormone expression in murine bone marrow cells is independent of the pituitary transcription factor Pit-1 .
7708713	0	Pit-1	109,114	P-Lim	0,5	Pit-1	P-Lim	18736(Tax:10090)	16871(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	P-Lim , a LIM homeodomain factor , is expressed during pituitary organ and cell commitment and synergizes with Pit-1 .
2211620	0	Pit-1	12,17	Pit-1	136,141	Pit-1	Pit-1	25517(Tax:10116)	25517(Tax:10116)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth_hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding .
2211620	0	Pit-1	136,141	Pit-1	12,17	Pit-1	Pit-1	25517(Tax:10116)	25517(Tax:10116)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth_hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding .
7923608	0	Pit-1	41,46	Pituitary-specific_transcription_factor	0,39	Pit-1	Pituitary-specific transcription factor	5449	5449	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Pituitary-specific_transcription_factor -LRB- Pit-1 -RRB- binding site in the human renin gene 5 ' - flanking DNA stimulates promoter activity in placental cell primary cultures and pituitary lactosomatotropic cell lines .
10411306	0	Pit-1	114,119	growth_hormone	15,29	Pit-1	growth hormone	403753(Tax:9615)	403795(Tax:9615)	Gene	Gene	absence|nmod|START_ENTITY site|nmod|absence initiates|nmod|site initiates|nsubj|transcription transcription|amod|END_ENTITY	Canine mammary growth_hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1 .
11149379	0	Pit-1	45,50	growth_hormone	29,43	Pit-1	growth hormone	5449	2688	Gene	Gene	dependence|compound|START_ENTITY END_ENTITY|dep|dependence	Pituitary and extrapituitary growth_hormone : Pit-1 dependence ?
11874696	0	Pit-1	24,29	growth_hormone	79,93	Pit-1	growth hormone	18736(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|nsubj|expression induces|ccomp|END_ENTITY	Exogenous expression of Pit-1 in AtT-20 corticotropic cells induces endogenous growth_hormone gene transcription .
1454833	0	Pit-1	49,54	growth_hormone	62,76	Pit-1	growth hormone	5449	2688	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Activin inhibits binding of transcription factor Pit-1 to the growth_hormone promoter .
15595273	0	Pit-1	125,130	growth_hormone	14,28	Pit-1	growth hormone	374215(Tax:9031)	378781(Tax:9031)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of growth_hormone expression by thyrotropin-releasing_hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary .
17047377	0	Pit-1	70,75	growth_hormone	24,38	Pit-1	growth hormone	5449	2688	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|family family|amod|END_ENTITY	Regulation of the human growth_hormone gene family : possible role for Pit-1 in early stages of pituitary-specific expression and repression .
18602461	0	Pit-1	132,137	growth_hormone	25,39	Pit-1	growth hormone	18736(Tax:10090)	14599(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY associated|nmod|suppression associated|nsubjpass|Reduction Reduction|nmod|END_ENTITY	Reduction in hypophyseal growth_hormone and prolactin expression due to deficiency in ghrelin_receptor signaling is associated with Pit-1 suppression : relevance to the immune system .
19427323	0	Pit-1	14,19	growth_hormone	63,77	Pit-1	growth hormone	5449	2688	Gene	Gene	Expression|nmod|START_ENTITY induces|nsubj|Expression induces|ccomp|control control|nsubj|locus locus|compound|END_ENTITY	Expression of Pit-1 in nonsomatotrope cell lines induces human growth_hormone locus control region histone modification and hGH-N transcription .
21703269	0	Pit-1	16,21	growth_hormone	45,59	Pit-1	growth hormone	374215(Tax:9031)	378781(Tax:9031)	Gene	Gene	Role|nmod|START_ENTITY isoforms|nsubj|Role isoforms|advcl|activating activating|dobj|gene gene|amod|END_ENTITY	Role of chicken Pit-1 isoforms in activating growth_hormone gene .
2211620	0	Pit-1	12,17	growth_hormone	71,85	Pit-1	growth hormone	25517(Tax:10116)	81668(Tax:10116)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|activity activity|compound|END_ENTITY	Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth_hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding .
2211620	0	Pit-1	136,141	growth_hormone	71,85	Pit-1	growth hormone	25517(Tax:10116)	81668(Tax:10116)	Gene	Gene	essential|nmod|START_ENTITY essential|nmod|activity activity|compound|END_ENTITY	Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth_hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding .
2550324	0	Pit-1	32,37	growth_hormone	54,68	Pit-1	growth hormone	5449	2688	Gene	Gene	protein|appos|START_ENTITY activates|nsubj|protein activates|dobj|promoters promoters|compound|END_ENTITY	A pituitary POU domain protein , Pit-1 , activates both growth_hormone and prolactin promoters transcriptionally .
7836893	0	Pit-1	40,45	growth_hormone	66,80	Pit-1	growth hormone	25517(Tax:10116)	81668(Tax:10116)	Gene	Gene	transcription|dobj|START_ENTITY transcription|nmod|rat rat|nmod|dwarfism dwarfism|amod|END_ENTITY	Pituitary-specific transcription factor Pit-1 in the rdw rat with growth_hormone - and prolactin-deficient dwarfism .
7920986	0	Pit-1	0,5	growth_hormone	24,38	Pit-1	growth hormone	5449	2688	Gene	Gene	role|compound|START_ENTITY role|nmod|regulation regulation|amod|END_ENTITY	Pit-1 and Pit-2 role in growth_hormone gene regulation .
8316253	0	Pit-1	33,38	growth_hormone	101,115	Pit-1	growth hormone	25517(Tax:10116)	81668(Tax:10116)	Gene	Gene	interactions|nmod|START_ENTITY required|nsubjpass|interactions required|nmod|expression expression|compound|END_ENTITY	Synergistic interactions between Pit-1 and other elements are required for effective somatotroph rat growth_hormone gene expression in transgenic_mice .
8441408	0	Pit-1	18,23	growth_hormone	103,117	Pit-1	growth hormone	25517(Tax:10116)	81668(Tax:10116)	Gene	Gene	Ligand-dependent|dep|START_ENTITY Ligand-dependent|parataxis|GHF-1 GHF-1|dep|stimulation stimulation|nmod|expression expression|compound|END_ENTITY	Ligand-dependent , Pit-1 / growth_hormone_factor-1 -LRB- GHF-1 -RRB- - independent transcriptional stimulation of rat growth_hormone gene expression by thyroid hormone receptors in vitro .
8730655	0	Pit-1	46,51	growth_hormone	54,68	Pit-1	growth hormone	25517(Tax:10116)	81668(Tax:10116)	Gene	Gene	pituitary_transcription_factor-1|appos|START_ENTITY END_ENTITY|nmod|pituitary_transcription_factor-1	Ontogeny of pituitary_transcription_factor-1 -LRB- Pit-1 -RRB- , growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- mRNA levels in male and female rats and the differential expression of Pit-1 in lactotrophs and somatotrophs .
8879985	0	Pit-1	8,13	growth_hormone	40,54	Pit-1	growth hormone	5449	2688	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Pit-1 in the gene expression of growth_hormone , prolactin , and thyrotropin .
9392393	0	Pit-1	100,105	growth_hormone	35,49	Pit-1	growth hormone	5449	2688	Gene	Gene	mutation|compound|START_ENTITY due|nmod|mutation stimulating|xcomp|due stimulating|nmod|pituitary_deficiencies pituitary_deficiencies|nmod|END_ENTITY	Combined pituitary_deficiencies of growth_hormone , thyroid stimulating hormone and prolactin due to Pit-1 gene mutation : a case report .
9626142	0	Pit-1	45,50	growth_hormone	94,108	Pit-1	growth hormone	5449	2688	Gene	Gene	gene|compound|START_ENTITY gene|nmod|children children|nmod|END_ENTITY	Pro239Ser : a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth_hormone , prolactin , and thyrotropin_deficiency .
17380130	0	Pit-1	72,77	p53	78,81	Pit-1	p53	18736(Tax:10090)	22060(Tax:10090)	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1 / p53 pathway , preventing tumor growth .
20807761	0	Pit-1	166,171	pituitary_transcription_factor_1	132,164	Pit-1	pituitary transcription factor 1	18736(Tax:10090)	18736(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MicroRNAs regulate pituitary development , and microRNA 26b specifically targets lymphoid_enhancer_factor_1 -LRB- Lef-1 -RRB- , which modulates pituitary_transcription_factor_1 -LRB- Pit-1 -RRB- expression .
10936041	0	Pit-1	66,71	prolactin	33,42	Pit-1	prolactin	374215(Tax:9031)	396453(Tax:9031)	Gene	Gene	factor|amod|START_ENTITY END_ENTITY|nmod|factor	Molecular cloning of the chicken prolactin gene and activation by Pit-1 and cAMP-induced factor in GH3 cells .
15031321	0	Pit-1_and_menin	79,94	Activin	0,7	Pit-1 and menin	Activin	5449	83729	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Activin inhibits pituitary prolactin expression and cell growth through Smads , Pit-1_and_menin .
18272476	0	Pit1	26,30	Atbf1	0,5	Pit1	Atbf1	5449	463	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Atbf1 is required for the Pit1 gene early activation .
7923608	0	Pituitary-specific_transcription_factor	0,39	Pit-1	41,46	Pituitary-specific transcription factor	Pit-1	5449	5449	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Pituitary-specific_transcription_factor -LRB- Pit-1 -RRB- binding site in the human renin gene 5 ' - flanking DNA stimulates promoter activity in placental cell primary cultures and pituitary lactosomatotropic cell lines .
16427158	0	Pituitary_adenylate_cyclase-activating_peptide	0,46	interleukin-6	80,93	Pituitary adenylate cyclase-activating peptide	interleukin-6	24166(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|cells cells|amod|END_ENTITY	Pituitary_adenylate_cyclase-activating_peptide -LRB- PACAP -RRB- stimulates production of interleukin-6 in rat M ller cells .
8615842	0	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	corticosteroid-binding_globulin	73,104	Pituitary adenylate cyclase-activating polypeptide	corticosteroid-binding globulin	24166(Tax:10116)	299270(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide induces expression of corticosteroid-binding_globulin in cultured fetal hepatocytes : synergy with tri-iodothyronine .
8243297	0	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	prolactin	62,71	Pituitary adenylate cyclase-activating polypeptide	prolactin	24166(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide stimulates prolactin gene expression in a rat pituitary cell line .
7912096	0	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	vasoactive_intestinal_polypeptide	94,127	Pituitary adenylate cyclase-activating polypeptide	vasoactive intestinal polypeptide	11516(Tax:10090)	22353(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide induces cAMP production independently from vasoactive_intestinal_polypeptide in osteoblast-like cells .
9733069	0	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	PACAP	52,57	Pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- expression in sympathetic preganglionic projection neurons to the superior cervical ganglion .
7909910	0	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	TH	99,101	Pituitary adenylate cyclase activating polypeptide	TH	615187(Tax:9913)	280707(Tax:9913)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|appos|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- potently enhances tyrosine_hydroxylase -LRB- TH -RRB- expression in adrenal chromaffin cells .
9165043	0	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	interleukin-6	109,122	Pituitary adenylate cyclase activating polypeptide	interleukin-6	24166(Tax:10116)	24498(Tax:10116)	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|production production|amod|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- and vasoactive intestinal peptide -LRB- VIP -RRB- stimulate interleukin-6 production through the third subtype of PACAP/VIP receptor in rat bone marrow-derived stromal cells .
7909910	0	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	tyrosine_hydroxylase	77,97	Pituitary adenylate cyclase activating polypeptide	tyrosine hydroxylase	615187(Tax:9913)	280707(Tax:9913)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- potently enhances tyrosine_hydroxylase -LRB- TH -RRB- expression in adrenal chromaffin cells .
9242621	0	Pituitary_adenylyl_cyclase-activating_peptide	0,45	extracellular_signal-regulated_kinase_1_or_2	57,101	Pituitary adenylyl cyclase-activating peptide	extracellular signal-regulated kinase 1 or 2	24166(Tax:10116)	50689;116590	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Pituitary_adenylyl_cyclase-activating_peptide stimulates extracellular_signal-regulated_kinase_1_or_2 -LRB- ERK1/2 -RRB- activity in a Ras-independent , mitogen-activated protein Kinase/ERK kinase 1 or 2-dependent manner in PC12 cells .
16087728	0	Pituitary_homeobox_1	0,20	LHbeta	44,50	Pituitary homeobox 1	LHbeta	113983(Tax:10116)	25329(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Pituitary_homeobox_1 -LRB- Pitx1 -RRB- stimulates rat LHbeta gene expression via two functional DNA-regulatory regions .
20372070	0	Pituitary_homeobox_2	0,20	cyclin_D2	78,87	Pituitary homeobox 2	cyclin D2	5308	894	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Pituitary_homeobox_2 -LRB- PITX2 -RRB- promotes thyroid_carcinogenesis by activation of cyclin_D2 .
9915854	0	Pituitary_tumor-transforming_gene	0,33	DnaJ	111,115	Pituitary tumor-transforming gene	DnaJ	9232	10294	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Pituitary_tumor-transforming_gene protein associates with ribosomal_protein_S10 and a novel human homologue of DnaJ in testicular cells .
9915854	0	Pituitary_tumor-transforming_gene	0,33	ribosomal_protein_S10	58,79	Pituitary tumor-transforming gene	ribosomal protein S10	9232	6204	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Pituitary_tumor-transforming_gene protein associates with ribosomal_protein_S10 and a novel human homologue of DnaJ in testicular cells .
26201898	0	Pituitary_tumor-transforming_gene_1	0,35	MMP13	88,93	Pituitary tumor-transforming gene 1	MMP13	9232	4322	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Pituitary_tumor-transforming_gene_1 regulates invasion of prostate_cancer cells through MMP13 .
26201898	0	Pituitary_tumor-transforming_gene_1	0,35	MMP13	88,93	Pituitary tumor-transforming gene 1	MMP13	9232	4322	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Pituitary_tumor-transforming_gene_1 regulates invasion of prostate_cancer cells through MMP13 .
26383522	0	Pituitary_tumor-transforming_gene_1	0,35	ZEB1	108,112	Pituitary tumor-transforming gene 1	ZEB1	9232	6935	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Pituitary_tumor-transforming_gene_1 enhances metastases of cervical_cancer cells through miR-3666-regulated ZEB1 .
17096843	0	Pituitary_tumor_transforming_gene	49,82	PTTG	84,88	Pituitary tumor transforming gene	PTTG	9232	9232	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of angiogenesis and invasion by human Pituitary_tumor_transforming_gene -LRB- PTTG -RRB- through increased expression and secretion of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- .
18663361	0	Pituitary_tumor_transforming_gene_1	0,35	Aurora_kinase_A	46,61	Pituitary tumor transforming gene 1	Aurora kinase A	9232	6790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Pituitary_tumor_transforming_gene_1 regulates Aurora_kinase_A activity .
23677169	0	Pituitary_tumor_transforming_gene_1	0,35	tumor_necrosis_factor-a	44,67	Pituitary tumor transforming gene 1	tumor necrosis factor-a	9232	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Pituitary_tumor_transforming_gene_1 induces tumor_necrosis_factor-a production from keratinocytes : implication for involvement in the pathophysiology of psoriasis .
11520678	0	Pitx1	40,45	Pitx2b	47,53	Pitx1	Pitx2b	398122(Tax:8355)	398033(Tax:8355)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential gene expression of Xenopus Pitx1 , Pitx2b and Pitx2c during cement gland , stomodeum and pituitary development .
17762884	0	Pitx1	37,42	p53	30,33	Pitx1	p53	5307	7157	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of p53 by Pitx1 .
20816801	0	Pitx2	84,89	p21	104,107	Pitx2	p21	18741(Tax:10090)	12575(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21 .
23131154	0	Pitx2	0,5	p21	26,29	Pitx2	p21	5308	1026	Gene	Gene	expression|amod|START_ENTITY promotes|nsubj|expression promotes|dobj|expression expression|amod|END_ENTITY	Pitx2 expression promotes p21 expression and cell cycle exit in neural stem cells .
11520678	0	Pitx2b	47,53	Pitx1	40,45	Pitx2b	Pitx1	398033(Tax:8355)	398122(Tax:8355)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential gene expression of Xenopus Pitx1 , Pitx2b and Pitx2c during cement gland , stomodeum and pituitary development .
24307298	0	Pitx3	0,5	Foxe3	25,30	Pitx3	Foxe3	18742(Tax:10090)	30923(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Pitx3 directly regulates Foxe3 during early lens development .
19144721	0	Pitx3	0,5	Nurr1	18,23	Pitx3	Nurr1	5309	4929	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression .
22363463	0	Pitx3	21,26	Nurr1	41,46	Pitx3	Nurr1	18742(Tax:10090)	18227(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Direct regulation of Pitx3 expression by Nurr1 in culture and in developing mouse midbrain .
11299318	0	Pitx3	0,5	tyrosine_hydroxylase	22,42	Pitx3	tyrosine hydroxylase	18742(Tax:10090)	21823(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Pitx3 activates mouse tyrosine_hydroxylase promoter via a high-affinity binding site .
15950611	0	Pitx3	0,5	tyrosine_hydroxylase	16,36	Pitx3	tyrosine hydroxylase	18742(Tax:10090)	21823(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Pitx3 regulates tyrosine_hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development .
17184956	0	Pitx3	73,78	tyrosine_hydroxylase	13,33	Pitx3	tyrosine hydroxylase	5309	7054	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of tyrosine_hydroxylase expression by the transcription factor Pitx3 .
24178558	0	Piwi	31,35	HITS-CLIP	0,9	Piwi	HITS-CLIP	34521(Tax:7227)	18976(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	HITS-CLIP -LRB- CLIP-Seq -RRB- for mouse Piwi proteins .
25038252	0	Piwi	10,14	Hiwi2	23,28	Piwi	Hiwi2	9271	143689	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nsubj|protein	The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells .
25113562	0	Piwil2	0,6	Keratin_8	16,25	Piwil2	Keratin 8	55124	3856	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Piwil2 Inhibits Keratin_8 Degradation through Promoting p38-Induced Phosphorylation To Resist Fas-Mediated Apoptosis .
22303479	0	Piwil2	0,6	p53	18,21	Piwil2	p53	55124	7157	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Piwil2 suppresses p53 by inducing phosphorylation of signal_transducer_and_activator_of_transcription_3 in tumor cells .
8670805	0	Pkc1	69,73	Cdc28	92,97	Pkc1	Cdc28	852169(Tax:4932)	852457(Tax:4932)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	A pathway in the yeast cell division cycle linking protein_kinase_C -LRB- Pkc1 -RRB- to activation of Cdc28 at START .
16157662	0	Pkc1	0,4	Zds1	18,22	Pkc1	Zds1	852169(Tax:4932)	855316(Tax:4932)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Pkc1 acts through Zds1 and Gic1 to suppress growth and cell polarity defects of a yeast eIF5A mutant .
9716661	0	Pkd2	58,62	polycystic_kidney_disease	31,56	Pkd2	polycystic kidney disease	18764(Tax:10090)	18764(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the murine polycystic_kidney_disease -LRB- Pkd2 -RRB- gene .
18435913	0	Pkn1	52,56	TNFalpha	28,36	Pkn1	TNFalpha	320795(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse_osteosarcoma-derived FBJ cells .
13678940	0	PlA1	68,72	GP_IIIa	74,81	PlA1	GP IIIa	25833	3690	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Resistance in vitro to low-dose aspirin is associated with platelet PlA1 -LRB- GP_IIIa -RRB- polymorphism but not with C807T -LRB- GP_Ia / IIa -RRB- and C-5T Kozak -LRB- GP_Ibalpha -RRB- polymorphisms .
10195947	0	PlA2	65,69	GPIIIa	58,64	PlA2	GPIIIa	5319	3690	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Increased platelet_aggregability associated with platelet GPIIIa PlA2 polymorphism : the Framingham Offspring Study .
9400995	0	PlGF	39,43	Flt-1	71,76	PlGF	Flt-1	94203(Tax:10116)	54251(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|dep|END_ENTITY	Upregulation of the angiogenic factors PlGF , VEGF and their receptors -LRB- Flt-1 , Flk-1 / KDR -RRB- by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter_hypervascularization .
19658040	0	PlGF	45,49	Flt1	51,55	PlGF	Flt1	5228	2321	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Mutation analysis of the growth factor genes PlGF , Flt1 , IGF-I , and IGF-IR in intrauterine_growth_restriction with abnormal placental blood flow .
19658040	0	PlGF	45,49	IGF-I	57,62	PlGF	IGF-I	5228	3479	Gene	Gene	analysis|nmod|START_ENTITY END_ENTITY|nsubj|analysis	Mutation analysis of the growth factor genes PlGF , Flt1 , IGF-I , and IGF-IR in intrauterine_growth_restriction with abnormal placental blood flow .
16223445	0	PlGF	38,42	Placenta_growth_factor	14,36	PlGF	Placenta growth factor	5228	5228	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Placenta_growth_factor -LRB- PlGF -RRB- in non-small cell lung_cancer -LRB- NSCLC -RRB- and the clinical and prognostic significance .
9892094	0	PlGF	24,28	Placenta_growth_factor	0,22	PlGF	Placenta growth factor	5228	5228	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Placenta_growth_factor -LRB- PlGF -RRB- mRNA expression in brain_tumors .
10606981	0	PlGF	24,28	VEGF	74,78	PlGF	VEGF	5228	7422	Gene	Gene	Placenta_growth_factor|appos|START_ENTITY induces|nsubj|Placenta_growth_factor induces|dobj|secretion secretion|appos|END_ENTITY	Placenta_growth_factor -LRB- PlGF -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid .
11006323	0	PlGF	85,89	VEGF	50,54	PlGF	VEGF	701219(Tax:9544)	574209(Tax:9544)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and placental_growth_factor -LRB- PlGF -RRB- in conceptus and endometrium during implantation in the rhesus_monkey .
12796773	0	PlGF	8,12	VEGF	69,73	PlGF	VEGF	18654(Tax:10090)	22339(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|talk talk|nmod|Flt1 Flt1|compound|END_ENTITY	Role of PlGF in the intra - and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 .
18258238	0	PlGF	45,49	VEGF	0,4	PlGF	VEGF	18654(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulation|nmod|expression function|nmod|upregulation function|nsubj|END_ENTITY	VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis .
7478581	0	PlGF	104,108	VEGF	52,56	PlGF	VEGF	5228	7422	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and downregulation of placenta_growth_factor -LRB- PlGF -RRB- associated with malignancy in human thyroid_tumors and cell lines .
9886308	0	PlGF	86,90	VEGF	44,48	PlGF	VEGF	5228	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and placenta-derived growth factor -LRB- PlGF -RRB- in regulating human haemopoietic cell growth .
17194893	0	PlGF	19,23	VEGFR-2	48,55	PlGF	VEGFR-2	5228	3791	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Chimeric VEGF-ENZ7 / PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization .
15117604	0	PlGF	48,52	placenta_growth_factor	24,46	PlGF	placenta growth factor	5228	5228	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Prospective analysis of placenta_growth_factor -LRB- PlGF -RRB- concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia .
17917370	0	PlGF	66,70	placenta_growth_factor	42,64	PlGF	placenta growth factor	94203(Tax:10116)	94203(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Streptozotocin-induced diabetes decreases placenta_growth_factor -LRB- PlGF -RRB- levels in rat placenta .
26105949	0	PlGF	42,46	placental_growth_factor	17,40	PlGF	placental growth factor	5228	5228	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Determination of placental_growth_factor -LRB- PlGF -RRB- levels in healthy pregnant women without signs or symptoms of preeclampsia .
7478581	0	PlGF	104,108	vascular_endothelial_growth_factor	16,50	PlGF	vascular endothelial growth factor	5228	7422	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and downregulation of placenta_growth_factor -LRB- PlGF -RRB- associated with malignancy in human thyroid_tumors and cell lines .
8148155	0	PlGF-2	50,56	placenta_growth_factor	26,48	PlGF-2	placenta growth factor	5228	5228	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	A heparin-binding form of placenta_growth_factor -LRB- PlGF-2 -RRB- is expressed in human umbilical vein endothelial cells and in placenta .
18650418	0	Pla	22,25	DEC-205	61,68	Pla	DEC-205	13917718	17076(Tax:10090)	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|END_ENTITY	Plasminogen activator Pla of Yersinia_pestis utilizes murine DEC-205 -LRB- CD205 -RRB- as a receptor to promote dissemination .
16223445	0	Placenta_growth_factor	14,36	PlGF	38,42	Placenta growth factor	PlGF	5228	5228	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Placenta_growth_factor -LRB- PlGF -RRB- in non-small cell lung_cancer -LRB- NSCLC -RRB- and the clinical and prognostic significance .
9892094	0	Placenta_growth_factor	0,22	PlGF	24,28	Placenta growth factor	PlGF	5228	5228	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Placenta_growth_factor -LRB- PlGF -RRB- mRNA expression in brain_tumors .
10606981	0	Placenta_growth_factor	0,22	vascular_endothelial_growth_factor	38,72	Placenta growth factor	vascular endothelial growth factor	5228	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Placenta_growth_factor -LRB- PlGF -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid .
26529476	0	Placental_Growth_Factor	35,58	Vascular_Endothelial_Growth_Factor	0,34	Placental Growth Factor	Vascular Endothelial Growth Factor	5228	7422	Gene	Gene	Levels|compound|START_ENTITY END_ENTITY|dep|Levels	Vascular_Endothelial_Growth_Factor / Placental_Growth_Factor Heterodimer Levels in Preterm Infants with Bronchopulmonary_Dysplasia .
20150869	0	Placental_Leucine_Aminopeptidase	26,58	P-LAP	60,65	Placental Leucine Aminopeptidase	P-LAP	4012	4012	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Alteration of circulating Placental_Leucine_Aminopeptidase -LRB- P-LAP -RRB- activity in preeclampsia .
14741347	0	Placental_growth_factor	0,23	FosB	32,36	Placental growth factor	FosB	5228	2354	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Placental_growth_factor induces FosB and c-Fos gene expression via Flt-1 receptors .
24188108	0	Placental_growth_factor	0,23	pregnancy-associated_plasma_protein-A	25,62	Placental growth factor	pregnancy-associated plasma protein-A	5228	5069	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	Placental_growth_factor , pregnancy-associated_plasma_protein-A , soluble receptor for advanced glycation end products , extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high_mobility_group_box_1 levels in patients with acute_kidney_injury : a cross sectional study .
15491750	0	Placental_leucine_aminopeptidase	0,32	P-LAP	34,39	Placental leucine aminopeptidase	P-LAP	4012	4012	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Placental_leucine_aminopeptidase -LRB- P-LAP -RRB- expression is associated with chemosensitivity in human endometrial_carcinoma .
2789118	0	Placental_protein_14	0,20	interleukin-2	54,67	Placental protein 14	interleukin-2	5047	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|END_ENTITY	Placental_protein_14 -LRB- PP14 -RRB- inhibits the synthesis of interleukin-2 and the release of soluble interleukin-2 receptors from phytohaemagglutinin-stimulated lymphocytes .
21263445	0	PlagL2	25,31	Mpl	42,45	PlagL2	Mpl	54711(Tax:10090)	17480(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells .
25995992	0	Plakophilin-2	0,13	EGFR	22,26	Plakophilin-2	EGFR	5318	1956	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Plakophilin-2 induced EGFR phosphorylation : a focus on the intracellular activators of EGFR .
25995992	0	Plakophilin-2	0,13	EGFR	87,91	Plakophilin-2	EGFR	5318	1956	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|dep|focus focus|nmod|activators activators|nmod|END_ENTITY	Plakophilin-2 induced EGFR phosphorylation : a focus on the intracellular activators of EGFR .
17391671	0	Plakophilin_3	51,64	ZEB1	25,29	Plakophilin 3	ZEB1	11187	6935	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	The transcription factor ZEB1 -LRB- deltaEF1 -RRB- represses Plakophilin_3 during human cancer progression .
26285765	0	Plasma_Membrane_Monoamine_Transporter	35,72	PMAT	74,78	Plasma Membrane Monoamine Transporter	PMAT	222962	222962	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Potent and Selective Inhibition of Plasma_Membrane_Monoamine_Transporter -LRB- PMAT -RRB- by HIV Protease Inhibitors .
21965681	0	Plasma_membrane_calcium_pump	0,28	neuronal_nitric-oxide_synthase	37,67	Plasma membrane calcium pump	neuronal nitric-oxide synthase	491	4842	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	Plasma_membrane_calcium_pump -LRB- PMCA4 -RRB- - neuronal_nitric-oxide_synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain .
25944790	0	Plasmin	120,127	Protease-Activated_Receptor_2	142,171	Plasmin	Protease-Activated Receptor 2	5340	2150	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	a-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated_Receptor_2 .
2140913	0	Plasmin	0,7	fibrinogen	27,37	Plasmin	fibrinogen	5340	2244	Gene	Gene	digestion|compound|START_ENTITY digestion|nmod|END_ENTITY	Plasmin digestion of human fibrinogen previously phosphorylated by protein kinase C or dephosphorylated by alkaline phosphatase in vitro .
2524834	0	Plasmin	0,7	fibrinogen	60,70	Plasmin	fibrinogen	5340	2244	Gene	Gene	catalyzes|nsubj|START_ENTITY catalyzes|dobj|binding binding|nmod|lipoprotein lipoprotein|acl|immobilized immobilized|dobj|END_ENTITY	Plasmin catalyzes binding of lipoprotein -LRB- a -RRB- to immobilized fibrinogen and fibrin .
23576799	0	Plasmin	0,7	intercellular_adhesion_molecule_1	16,49	Plasmin	intercellular adhesion molecule 1	5340	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Plasmin induces intercellular_adhesion_molecule_1 expression in human endothelial cells via nuclear factor-kB/mitogen-activated protein kinases-dependent pathways .
1654795	0	Plasmin	0,7	plasminogen	23,34	Plasmin	plasminogen	5340	5340	Gene	Gene	binding|compound|START_ENTITY binding|nmod|receptor receptor|compound|END_ENTITY	Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding .
1713175	0	Plasmin	0,7	vitronectin	20,31	Plasmin	vitronectin	5340	7448	Gene	Gene	cleavage|nsubj|START_ENTITY cleavage|nmod|END_ENTITY	Plasmin cleavage of vitronectin .
7556434	0	Plasmin	0,7	vitronectin	96,107	Plasmin	vitronectin	5340	7448	Gene	Gene	abrogates|nsubj|START_ENTITY abrogates|nmod|END_ENTITY	Plasmin abrogates alpha v beta_5-mediated adhesion of a human keratinocyte cell line -LRB- HaCaT -RRB- to vitronectin .
2588818	0	Plasminogen	0,11	PLG	13,16	Plasminogen	PLG	5340	5340	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Plasminogen -LRB- PLG -RRB- polymorphism in northern Japanese : confirmation of PLG * M6 allele .
2617455	0	Plasminogen	0,11	fibrinogen	42,52	Plasminogen	fibrinogen	5340	2244	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Plasminogen interactions with immobilized fibrinogen .
17663741	0	Plasminogen	0,11	nerve_growth_factor	44,63	Plasminogen	nerve growth factor	85253(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Plasminogen gene expression is regulated by nerve_growth_factor .
9674732	0	Plasminogen	0,11	u-PA	58,62	Plasminogen	u-PA	5340	5328	Gene	Gene	activator|compound|START_ENTITY activator|dep|END_ENTITY	Plasminogen activator in acute myeloid leukaemic marrows : u-PA in contrast to t-PA in normal marrow .
16763560	0	Plasminogen	0,11	uPA	38,41	Plasminogen	uPA	18815(Tax:10090)	18792(Tax:10090)	Gene	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice .
17578681	0	Plasminogen_Activator_Inhibitor-1	0,33	PAI-1	35,40	Plasminogen Activator Inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Plasminogen_Activator_Inhibitor-1 -LRB- PAI-1 -RRB- gene 4G/5G alleles frequency distribution in the Lebanese population .
17903340	0	Plasminogen_Activator_Inhibitor_1	35,68	PAI-1	70,75	Plasminogen Activator Inhibitor 1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The -675 4G/5G polymorphism at the Plasminogen_Activator_Inhibitor_1 -LRB- PAI-1 -RRB- gene modulates plasma Plasminogen_Activator_Inhibitor_1 concentrations in response to dietary fat consumption .
8560407	0	Plasminogen_activator_inhibitor-1	0,33	PAI-1	35,40	Plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- promoter polymorphism and coronary_artery_disease in non-insulin-dependent_diabetes .
9279972	0	Plasminogen_activator_inhibitor-1	0,33	PAI-1	35,40	Plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- content in platelets from healthy individuals genotyped for the 4G/5G polymorphism in the PAI-1 gene .
14980508	0	Plasminogen_activator_inhibitor-1	0,33	VEGF	62,66	Plasminogen activator inhibitor-1	VEGF	5054	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Plasminogen_activator_inhibitor-1 increases the expression of VEGF in human glioma cells .
17540775	0	Plasminogen_activator_inhibitor-1	0,33	factor_VII-activating_protease	53,83	Plasminogen activator inhibitor-1	factor VII-activating protease	5054	3026	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Plasminogen_activator_inhibitor-1 is an inhibitor of factor_VII-activating_protease in patients with acute_respiratory_distress_syndrome .
19487690	0	Plasminogen_activator_inhibitor-1	0,33	integrin_alphavbeta3	44,64	Plasminogen activator inhibitor-1	integrin alphavbeta3	5054	3685	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Plasminogen_activator_inhibitor-1 regulates integrin_alphavbeta3 expression and autocrine transforming_growth_factor_beta signaling .
16862142	0	Plasminogen_activator_inhibitor-1	0,33	p53	69,72	Plasminogen activator inhibitor-1	p53	5054	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Plasminogen_activator_inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence .
3124286	0	Plasminogen_activator_inhibitor-1	0,33	tissue-type_plasminogen_activator	62,95	Plasminogen activator inhibitor-1	tissue-type plasminogen activator	5054	5327	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Plasminogen_activator_inhibitor-1 is the primary inhibitor of tissue-type_plasminogen_activator in pregnancy plasma .
1563535	0	Plasminogen_activator_inhibitor_1	0,33	insulin	64,71	Plasminogen activator inhibitor 1	insulin	5054	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|resistance resistance|compound|END_ENTITY	Plasminogen_activator_inhibitor_1 and insulin levels in various insulin resistance states .
12505065	0	Plasminogen_activator_inhibitor_1	0,33	interleukin-1alpha	88,106	Plasminogen activator inhibitor 1	interleukin-1alpha	5054	3552	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Plasminogen_activator_inhibitor_1 expression is regulated by the inflammatory mediators interleukin-1alpha , tumor_necrosis_factor-alpha , transforming_growth_factor-beta and oncostatin_M in human cardiac myocytes .
8635500	0	Plasminogen_activator_inhibitor_type-2	0,38	urokinase-type_plasminogen_activator	93,129	Plasminogen activator inhibitor type-2	urokinase-type plasminogen activator	5055	5328	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Plasminogen_activator_inhibitor_type-2 -LRB- PAI-2 -RRB- in human keratinocytes regulates pericellular urokinase-type_plasminogen_activator .
8824249	0	Plasminogen_activator_inhibitor_type_2	0,38	tumor_necrosis_factor	57,78	Plasminogen activator inhibitor type 2	tumor necrosis factor	5055	7124	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Plasminogen_activator_inhibitor_type_2 gene induction by tumor_necrosis_factor and phorbol_ester involves transcriptional and post-transcriptional events .
26752520	0	Platelet-Derived_Growth_Factor-B	12,44	Platelet-Derived_Growth_Factor_Receptor-b	45,86	Platelet-Derived Growth Factor-B	Platelet-Derived Growth Factor Receptor-b	5155	5159	Gene	Gene	Role|nmod|START_ENTITY Role|dep|Signaling Signaling|compound|END_ENTITY	The Role of Platelet-Derived_Growth_Factor-B / Platelet-Derived_Growth_Factor_Receptor-b Signaling in Chronic Atrial_Fibrillation .
26208383	0	Platelet-Derived_Growth_Factor_Receptor-b	144,185	Akt	83,86	Platelet-Derived Growth Factor Receptor-b	Akt	5159	207	Gene	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate_Receptor_3 / Platelet-Derived_Growth_Factor_Receptor-b .
26752520	0	Platelet-Derived_Growth_Factor_Receptor-b	45,86	Platelet-Derived_Growth_Factor-B	12,44	Platelet-Derived Growth Factor Receptor-b	Platelet-Derived Growth Factor-B	5159	5155	Gene	Gene	Signaling|compound|START_ENTITY Role|dep|Signaling Role|nmod|END_ENTITY	The Role of Platelet-Derived_Growth_Factor-B / Platelet-Derived_Growth_Factor_Receptor-b Signaling in Chronic Atrial_Fibrillation .
1846878	0	Platelet-activating_factor	0,26	PAF_acetylhydrolase	62,81	Platelet-activating factor	PAF acetylhydrolase	9768	7941	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Platelet-activating_factor -LRB- PAF -RRB- stimulates the production of PAF_acetylhydrolase by the human hepatoma cell line , HepG2 .
2162881	0	Platelet-activating_factor	0,26	angiotensin_converting_enzyme	38,67	Platelet-activating factor	angiotensin converting enzyme	9768	1636	Gene	Gene	stimulates|compound|START_ENTITY END_ENTITY|nsubj|stimulates	Platelet-activating_factor stimulates angiotensin_converting_enzyme activity .
9058317	0	Platelet-activating_factor	0,26	interferon-gamma	55,71	Platelet-activating factor	interferon-gamma	9768	3458	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Platelet-activating_factor and the production of human interferon-gamma .
1937867	0	Platelet-activating_factor	0,26	interleukin-6	37,50	Platelet-activating factor	interleukin-6	109585(Tax:10090)	16193(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|amod|END_ENTITY	Platelet-activating_factor modulates interleukin-6 production by mouse fibroblasts .
19460845	0	Platelet-activating_factor	0,26	p105	75,79	Platelet-activating factor	p105	109585(Tax:10090)	18033(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|processing processing|nmod|END_ENTITY	Platelet-activating_factor induces the processing of nuclear factor-kappaB p105 into p50 , which mediates acute bowel_injury in mice .
19460845	0	Platelet-activating_factor	0,26	p50	85,88	Platelet-activating factor	p50	109585(Tax:10090)	18033(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Platelet-activating_factor induces the processing of nuclear factor-kappaB p105 into p50 , which mediates acute bowel_injury in mice .
17384835	0	Platelet-activating_factor_acetylhydrolase	0,42	PAF-AH	44,50	Platelet-activating factor acetylhydrolase	PAF-AH	5048	5048	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity in patients with type_1_diabetes_mellitus .
12794027	0	Platelet-derived_endothelial_cell_growth_factor	0,47	Rho-associated_coiled-coil_domain_kinase	57,97	Platelet-derived endothelial cell growth factor	Rho-associated coiled-coil domain kinase	1890	6093	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Platelet-derived_endothelial_cell_growth_factor mediates Rho-associated_coiled-coil_domain_kinase messenger RNA expression and promotes cell motility .
23254481	0	Platelet-derived_growth_factor-D	0,32	cyclooxygenase-2	55,71	Platelet-derived growth factor-D	cyclooxygenase-2	66018(Tax:10116)	29527(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Platelet-derived_growth_factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3K/PKB and PKCs .
22471482	0	Platelet-derived_growth_factor-D	0,32	matrix_metalloproteinases_2_and_9	80,113	Platelet-derived growth factor-D	matrix metalloproteinases 2 and 9	80310	4313;4318	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Platelet-derived_growth_factor-D promotes ovarian_cancer invasion by regulating matrix_metalloproteinases_2_and_9 .
21880906	0	Platelet-derived_growth_factor_B_chain	0,38	Notch1	82,88	Platelet-derived growth factor B chain	Notch1	5155	4851	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Platelet-derived_growth_factor_B_chain is a novel target gene of cocaine-mediated Notch1 signaling : implications for HIV-associated neurological_disorders .
15988036	0	Platelet-derived_growth_factor_D	0,32	urokinase_plasminogen_activator	49,80	Platelet-derived growth factor D	urokinase plasminogen activator	80310	5328	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Platelet-derived_growth_factor_D is activated by urokinase_plasminogen_activator in prostate_carcinoma cells .
21789698	0	Platelet-derived_growth_factor_receptor	0,39	PDGFR	41,46	Platelet-derived growth factor receptor	PDGFR	5159	5159	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Platelet-derived_growth_factor_receptor -LRB- PDGFR -RRB- expression in primary spinal cord_gliomas .
15944146	0	Platelet-derived_growth_factor_receptor-beta	0,44	PDGFR-beta	46,56	Platelet-derived growth factor receptor-beta	PDGFR-beta	5159	5159	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Platelet-derived_growth_factor_receptor-beta -LRB- PDGFR-beta -RRB- activation promotes its association with the low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- .
12128230	0	Platelet-derived_growth_factor_receptor_alpha	0,45	pdgfr-alpha	47,58	Platelet-derived growth factor receptor alpha	pdgfr-alpha	100148428(Tax:7955)	386856(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Platelet-derived_growth_factor_receptor_alpha -LRB- pdgfr-alpha -RRB- gene in zebrafish embryonic development .
12451264	0	Platelet-endothelial_cell_adhesion_molecule-1	0,45	CD31	47,51	Platelet-endothelial cell adhesion molecule-1	CD31	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Platelet-endothelial_cell_adhesion_molecule-1 -LRB- CD31 -RRB- expression on donor endothelial cells attenuates the development of transplant_arteriosclerosis .
23526143	0	Platelet-type_12-lipoxygenase	0,29	MMP9	38,42	Platelet-type 12-lipoxygenase	MMP9	239	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Platelet-type_12-lipoxygenase induces MMP9 expression and cellular invasion via activation of PI3K/Akt/NF-kB .
14518561	0	Platelet-type_12-lipoxygenase	0,29	NF-kappaB	40,49	Platelet-type 12-lipoxygenase	NF-kappaB	239	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Platelet-type_12-lipoxygenase activates NF-kappaB in prostate_cancer cells .
19150337	0	Platelet_Factor_4	15,32	Factor_Xa	54,63	Platelet Factor 4	Factor Xa	5196	2159	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Dual effect of Platelet_Factor_4 on the activities of Factor_Xa .
7783948	0	Platelet_activating_factor	0,26	nerve_growth_factor	35,54	Platelet activating factor	nerve growth factor	300795(Tax:10116)	310738(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Platelet_activating_factor induces nerve_growth_factor production by rat astrocytes .
23748876	0	Platelet_derived_growth_factor_receptor-beta	0,44	PDGFRb	46,52	Platelet derived growth factor receptor-beta	PDGFRb	5159	5159	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Platelet_derived_growth_factor_receptor-beta -LRB- PDGFRb -RRB- expression is limited to activated stromal cells in the bone marrow and shows a strong correlation with the grade of myelofibrosis .
9162084	0	Platelet_endothelial_cell_adhesion_molecule-1	0,45	c-Src	69,74	Platelet endothelial cell adhesion molecule-1	c-Src	5175	6714	Gene	Gene	phosphorylatable|nsubj|START_ENTITY phosphorylatable|nmod|domain domain|amod|binds binds|amod|END_ENTITY	Platelet_endothelial_cell_adhesion_molecule-1 is phosphorylatable by c-Src , binds Src-Src homology 2 domain , and exhibits immunoreceptor tyrosine-based activation motif-like properties .
24969778	0	Platelet_endothelial_cell_adhesion_molecule-1	0,45	thrombin	76,84	Platelet endothelial cell adhesion molecule-1	thrombin	18613(Tax:10090)	14061(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Platelet_endothelial_cell_adhesion_molecule-1 inhibits platelet response to thrombin and von_Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3 / dynamin and integrin aIIbb3 .
15728475	0	Platelet_factor_4	0,17	CD25	47,51	Platelet factor 4	CD25	5196	3559	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	Platelet_factor_4	0,17	CD25	77,81	Platelet factor 4	CD25	5196	3559	Gene	Gene	START_ENTITY|nsubj|+ +|nmod|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	Platelet_factor_4	0,17	CD4	43,46	Platelet factor 4	CD4	5196	920	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15728475	0	Platelet_factor_4	0,17	CD4	73,76	Platelet factor 4	CD4	5196	920	Gene	Gene	START_ENTITY|nsubj|+ +|nmod|CD25 CD25|compound|END_ENTITY	Platelet_factor_4 differentially modulates CD4 + CD25 + -LRB- regulatory -RRB- versus CD4 + CD25 - -LRB- nonregulatory -RRB- T cells .
15265941	0	Platelet_factor_4	0,17	CXCL4	18,23	Platelet factor 4	CXCL4	5196	5196	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Platelet_factor_4 / CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients .
20454664	0	Platelet_factor_4	0,17	KLF4	41,45	Platelet factor 4	KLF4	56744(Tax:10090)	16600(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Platelet_factor_4 regulation of monocyte KLF4 in experimental cerebral_malaria .
24799320	0	Platelet_factor_4	0,17	Stat3	33,38	Platelet factor 4	Stat3	56744(Tax:10090)	20848(Tax:10090)	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Platelet_factor_4 inhibits IL-17 / Stat3 pathway via upregulation of SOCS3 expression in melanoma .
8040268	0	Platelet_factor_4	0,17	basic_fibroblast_growth_factor	54,84	Platelet factor 4	basic fibroblast growth factor	5196	2247	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	Platelet_factor_4 modulates the mitogenic activity of basic_fibroblast_growth_factor .
14575696	0	Platelet_factor_4	0,17	factor_Xa	84,93	Platelet factor 4	factor Xa	5196	2159	Gene	Gene	neutralizes|nsubj|START_ENTITY neutralizes|dobj|inactivation inactivation|nmod|END_ENTITY	Platelet_factor_4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor_Xa by preventing interaction -LRB- s -RRB- of enzyme with polysaccharide .
9558385	0	Platelet_factor_4	0,17	fibroblast_growth_factor_2	28,54	Platelet factor 4	fibroblast growth factor 2	56744(Tax:10090)	14173(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Platelet_factor_4 modulates fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- activity and inhibits FGF-2 dimerization .
19605848	0	Platelet_factor_4	0,17	low-density_lipoprotein_receptor-related_protein_1	53,103	Platelet factor 4	low-density lipoprotein receptor-related protein 1	56744(Tax:10090)	16971(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Platelet_factor_4 regulates megakaryopoiesis through low-density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- on megakaryocytes .
21041299	0	Platelet_factor_4	0,17	thrombin	120,128	Platelet factor 4	thrombin	5196	2147	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Platelet_factor_4 inhibits thrombomodulin-dependent activation of thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- by thrombin .
7587389	0	Plcb3	90,95	MEN1	45,49	Plcb3	MEN1	5331	4221	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the mouse homologue of a human MEN1 candidate gene , phospholipase_C-beta_3 -LRB- Plcb3 -RRB- , to chromosome region 19B by FISH .
9642212	0	Pld1p	28,33	phospholipase_D	11,26	Pld1p	phospholipase D	853902(Tax:4932)	853902(Tax:4932)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for phospholipase_D -LRB- Pld1p -RRB- in growth , secretion , and regulation of membrane lipid synthesis in yeast .
18155192	0	Plectin	0,7	CXCR4	73,78	Plectin	CXCR4	5339	7852	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|nmod|END_ENTITY	Plectin regulates the signaling and trafficking of the HIV-1 co-receptor CXCR4 and plays a role in HIV-1_infection .
3027087	0	Plectin	0,7	microtubule-associated_proteins_1_and_2	57,96	Plectin	microtubule-associated proteins 1 and 2	5339	4133	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Plectin and IFAP-300K are homologous proteins binding to microtubule-associated_proteins_1_and_2 and to the 240-kilodalton subunit of spectrin .
24695857	0	Pleiotrophin	0,12	Brd2	25,29	Pleiotrophin	Brd2	5764	6046	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Pleiotrophin antagonizes Brd2 during neuronal differentiation .
25992615	0	Plekhm1	30,37	TRAFD1	0,6	Plekhm1	TRAFD1	9842	10906	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	TRAFD1 -LRB- FLN29 -RRB- Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption .
22128169	0	Plenty_of_SH3s	132,146	POSH	126,130	Plenty of SH3s	POSH	57630	57630	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun_N-terminal_kinase scaffold POSH -LRB- Plenty_of_SH3s -RRB- protein .
16179944	0	Plenty_of_SH3s	33,47	TAK1	56,60	Plenty of SH3s	TAK1	36990(Tax:7227)	39659(Tax:7227)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The RING-finger scaffold protein Plenty_of_SH3s targets TAK1 to control immunity signalling in Drosophila .
15462883	0	Plerocercoid_growth_factor	0,26	growth_hormone	49,63	Plerocercoid growth factor	growth hormone	5228	2688	Gene	Gene	START_ENTITY|dep|homologue homologue|nmod|END_ENTITY	Plerocercoid_growth_factor : a homologue of human growth_hormone .
15210733	0	Plexin-B1	0,9	ErbB-2	80,86	Plexin-B1	ErbB-2	5364	2064	Gene	Gene	START_ENTITY|parataxis|involves involves|ccomp|tyrosine tyrosine|dobj|END_ENTITY	Plexin-B1 / RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2 .
22378040	0	Plexin-B1	23,32	ErbB-2	0,6	Plexin-B1	ErbB-2	5364	2064	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	ErbB-2 signals through Plexin-B1 to promote breast_cancer metastasis .
20610402	0	Plexin-B1	14,23	PTEN	35,39	Plexin-B1	PTEN	5364	5728	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Semaphorin_4D / Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity , inducing growth cone collapse in hippocampal neurons .
17554007	0	Plexin-B1	19,28	Plexin-B2	0,9	Plexin-B1	Plexin-B2	235611(Tax:10090)	140570(Tax:10090)	Gene	Gene	modulates|dep|START_ENTITY modulates|amod|END_ENTITY	Plexin-B2 , but not Plexin-B1 , critically modulates neuronal migration and patterning of the developing nervous system in vivo .
12730235	0	Plexin-B1	90,99	Rnd1	22,26	Plexin-B1	Rnd1	5364	27289	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|interaction interaction|nmod|END_ENTITY	Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells .
20610402	0	Plexin-B1	14,23	Semaphorin_4D	0,13	Plexin-B1	Semaphorin 4D	5364	10507	Gene	Gene	stimulates|nsubj|START_ENTITY END_ENTITY|parataxis|stimulates	Semaphorin_4D / Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity , inducing growth cone collapse in hippocampal neurons .
21216304	0	Plexin-B1	0,9	miR-214	25,32	Plexin-B1	miR-214	5364	406996	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Plexin-B1 is a target of miR-214 in cervical_cancer and promotes the growth and invasion of HeLa cells .
17554007	0	Plexin-B2	0,9	Plexin-B1	19,28	Plexin-B2	Plexin-B1	140570(Tax:10090)	235611(Tax:10090)	Gene	Gene	modulates|amod|START_ENTITY modulates|dep|END_ENTITY	Plexin-B2 , but not Plexin-B1 , critically modulates neuronal migration and patterning of the developing nervous system in vivo .
15218527	0	Plexin-B3	0,9	semaphorin_5A	39,52	Plexin-B3	semaphorin 5A	5365	9037	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Plexin-B3 is a functional receptor for semaphorin_5A .
20946874	0	PlexinA1	0,8	PTK7	24,28	PlexinA1	PTK7	397805(Tax:8355)	398862(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PlexinA1 interacts with PTK7 and is required for neural crest migration .
26945060	0	PlexinA4	56,64	semaphorin3A	25,37	PlexinA4	semaphorin3A	91584	10371	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	TrkA mediates retrograde semaphorin3A signaling through PlexinA4 to regulate dendritic branching .
20727575	0	PlexinC1	104,112	Sema7A	73,79	PlexinC1	Sema7A	10154	8482	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1 .
26648031	0	PlexinD1	67,75	Akt	59,62	PlexinD1	Akt	23129	207	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Semaphorin_4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor .
22189792	0	Plexin_B1	23,32	Sema4D	0,6	Plexin B1	Sema4D	5364	10507	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Sema4D , the ligand for Plexin_B1 , suppresses c-Met activation and migration and promotes melanocyte survival and growth .
21029396	0	Plexin_B1	0,9	pp125FAK	38,46	Plexin B1	pp125FAK	5364	5747	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Plexin_B1 inhibits integrin-dependent pp125FAK and Rho activity in melanoma .
9154840	0	Plk	0,3	Cdc5	56,60	Plk	Cdc5	5347	855013(Tax:4932)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Plk is a functional homolog of Saccharomyces_cerevisiae Cdc5 , and elevated Plk activity induces multiple septation structures .
22202082	0	Plk1	42,46	14-3-3zeta	0,10	Plk1	14-3-3zeta	5347	7534	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	14-3-3zeta cooperates with phosphorylated Plk1 and is required for correct cytokinesis .
18378770	0	Plk1	0,4	Bora	45,49	Plk1	Bora	5347	79866	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Plk1 - and beta-TrCP-dependent degradation of Bora controls mitotic progression .
18566290	0	Plk1	63,67	Bora	0,4	Plk1	Bora	5347	79866	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Bora and the kinase Aurora_a cooperatively activate the kinase Plk1 and control mitotic entry .
17785528	0	Plk1	18,22	BubR1	42,47	Plk1	BubR1	5347	701	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions .
19503101	0	Plk1	86,90	BubR1	0,5	Plk1	BubR1	5347	701	Gene	Gene	activity|amod|START_ENTITY regulating|dobj|activity amplification|acl|regulating centrosome|dobj|amplification centrosome|nsubj|localizes localizes|amod|END_ENTITY	BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells .
24451569	0	Plk1	0,4	CLIP-170	20,28	Plk1	CLIP-170	5347	6249	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Plk1 phosphorylates CLIP-170 and regulates its binding to microtubules for chromosome alignment .
18250300	0	Plk1	9,13	Hbo1	33,37	Plk1	Hbo1	5347	11143	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing .
22535524	0	Plk1	0,4	Kif2b	38,43	Plk1	Kif2b	5347	84643	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation .
26242183	0	Plk1	0,4	MEK1/2	15,21	Plk1	MEK1/2	5347	5604;5605	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells .
26242183	0	Plk1	0,4	MEK1/2	15,21	Plk1	MEK1/2	5347	5604;5605	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells .
16860740	0	Plk1	21,25	NudC	0,4	Plk1	NudC	5347	10726	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	NudC is required for Plk1 targeting to the kinetochore and chromosome congression .
21947279	0	Plk1	0,4	Orc2	24,28	Plk1	Orc2	5347	4999	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress .
23345402	0	Plk1	14,18	PCM1	0,4	Plk1	PCM1	5347	5108	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry .
17218258	0	Plk1	66,70	PICH	0,4	Plk1	PICH	5347	54821	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	PICH , a centromere-associated SNF2 family ATPase , is regulated by Plk1 and required for the spindle checkpoint .
22621898	0	Plk1	0,4	PRC1	26,30	Plk1	PRC1	5347	9055	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis .
24706748	0	Plk1	0,4	PTEN	60,64	Plk1	PTEN	5347	5728	Gene	Gene	protein|amod|START_ENTITY phosphorylates|nsubj|protein phosphorylates|dobj|homolog homolog|appos|END_ENTITY	Plk1 protein phosphorylates phosphatase and tensin homolog -LRB- PTEN -RRB- and regulates its mitotic activity during the cell cycle .
25047839	0	Plk1	0,4	PTEN	24,28	Plk1	PTEN	18817(Tax:10090)	19211(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state .
25346190	0	Plk1	149,153	Polo-Like_Kinase_1	129,147	Plk1	Polo-Like Kinase 1	5347	5347	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Ligand-Based Pharmacophore Modeling , Atom-Based 3D-QSAR and Molecular Docking Studies on Substituted Thiazoles and Thiophenes as Polo-Like_Kinase_1 -LRB- Plk1 -RRB- Inhibitors .
21545375	0	Plk1	94,98	Polo-like_kinase_1	74,92	Plk1	Polo-like kinase 1	18817(Tax:10090)	18817(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Induction of antitumor immunity using dendritic cells electroporated with Polo-like_kinase_1 -LRB- Plk1 -RRB- mRNA in murine tumor models .
21635870	0	Plk1	0,4	RNF8	32,36	Plk1	RNF8	5347	9025	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Plk1 is negatively regulated by RNF8 .
22869522	0	Plk1	0,4	Sgt1	20,24	Plk1	Sgt1	5347	10910	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment .
18625707	0	Plk1	0,4	TRF1	24,28	Plk1	TRF1	5347	7013	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Plk1 phosphorylation of TRF1 is essential for its binding to telomeres .
19821153	0	Plk1	0,4	Topors	24,30	Plk1	Topors	5347	10210	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Plk1 phosphorylation of Topors is involved in its degradation .
26323689	0	Plk1	44,48	Usp16	0,5	Plk1	Usp16	5347	10600	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis .
26323689	0	Plk1	44,48	Usp16	0,5	Plk1	Usp16	5347	10600	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis .
23188630	0	Plk1	0,4	orc2	24,28	Plk1	orc2	5347	4999	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic_cancer .
24160708	0	Plk1	36,40	polo-like_kinase_1	16,34	Plk1	polo-like kinase 1	5347	5347	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Developments of polo-like_kinase_1 -LRB- Plk1 -RRB- inhibitors as anti-cancer agents .
12972611	0	Plk2	8,12	Snk	14,17	Plk2	Snk	20620(Tax:10090)	20620(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Plk2 -LRB- Snk -RRB- in mouse development and cell proliferation .
20889502	0	Plk3	0,4	HIF-1alpha	104,114	Plk3	HIF-1alpha	12795(Tax:10090)	15251(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha .
20940307	0	Plk3	45,49	PTEN	14,18	Plk3	PTEN	12795(Tax:10090)	19211(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|stability stability|compound|END_ENTITY	Regulation of PTEN stability and activity by Plk3 .
19490146	0	Plk3	0,4	p73	40,43	Plk3	p73	1263	7161	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation .
21059844	0	Plk4	45,49	Cep152	0,6	Plk4	Cep152	10733	22995	Gene	Gene	recruitment|nmod|START_ENTITY scaffold|nmod|recruitment acts|nmod|scaffold acts|nsubj|END_ENTITY	Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome .
21059850	0	Plk4	22,26	Cep152	0,6	Plk4	Cep152	10733	22995	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cep152 interacts with Plk4 and is required for centriole duplication .
22302995	0	Plk4	23,27	GCP6	0,4	Plk4	GCP6	10733	85378	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	GCP6 is a substrate of Plk4 and required for centriole duplication .
25795303	0	Plk4	39,43	Mib1	24,28	Plk4	Mib1	10733	57534	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis .
11408585	0	Plx1	21,25	Cdc25C	72,78	Plx1	Cdc25C	380481(Tax:8355)	398119(Tax:8355)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	The polo-like kinase Plx1 is required for activation of the phosphatase Cdc25C and cyclin B-Cdc2 in Xenopus oocytes .
15713843	0	Plx1	25,29	XErp1	40,45	Plx1	XErp1	380481(Tax:8355)	100101275(Tax:8355)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Xenopus polo-like kinase Plx1 regulates XErp1 , a novel inhibitor of APC/C activity .
20691905	0	Plzf	0,4	mTORC1	60,66	Plzf	mTORC1	7704	382056(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Plzf regulates germline progenitor self-renewal by opposing mTORC1 .
17187077	0	Pml	44,47	Oct4	63,67	Pml	Oct4	5371	5460	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells .
20395446	0	Podocalyxin	0,11	EBP50	12,17	Podocalyxin	EBP50	5420	9368	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Podocalyxin EBP50 ezrin molecular complex enhances the metastatic potential of renal_cell_carcinoma through recruiting Rac1 guanine_nucleotide exchange factor ARHGEF7 .
11719225	0	Podocalyxin	79,90	WT1	0,3	Podocalyxin	WT1	5420	7490	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin .
20962267	0	Podoplanin	0,10	CD44	27,31	Podoplanin	CD44	10630	960	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Podoplanin associates with CD44 to promote directional cell migration .
26081937	0	Podoplanin	0,10	VEGF-C	106,112	Podoplanin	VEGF-C	10630	7424	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Podoplanin is involved in the prognosis of head_and_neck_squamous_cell_carcinoma through interaction with VEGF-C .
18757399	0	Podoplanin	0,10	fos	22,25	Podoplanin	fos	14726(Tax:10090)	14281(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Podoplanin is a novel fos target gene in skin_carcinogenesis .
25514493	0	Pokemon	0,7	Smad4	31,36	Pokemon	Smad4	51341	4089	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pokemon -LRB- FBI-1 -RRB- interacts with Smad4 to repress TGF-b-induced transcriptional responses .
23807508	0	Pokemon	35,42	p38b	0,4	Pokemon	p38b	51341	5600	Gene	Gene	Target|nmod|START_ENTITY END_ENTITY|appos|Target	p38b , A Novel Regulatory Target of Pokemon in Hepatic Cells .
24465179	0	Pol3	33,37	Def1	0,4	Pol3	Def1	851456(Tax:4932)	853811(Tax:4932)	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Def1 promotes the degradation of Pol3 for polymerase exchange to occur during DNA-damage -- induced mutagenesis in Saccharomyces_cerevisiae .
26984527	0	PolDIP2	0,7	PrimPol	29,36	PolDIP2	PrimPol	26073	201973	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities .
15520469	0	Pol_mu	43,49	DNA_polymerase_mu	24,41	Pol mu	DNA polymerase mu	27434	27434	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of human DNA_polymerase_mu -LRB- Pol_mu -RRB- in a Burkitt 's _ lymphoma cell line affects the somatic hypermutation rate .
22824807	0	Pold2	18,23	STAT2	89,94	Pold2	STAT2	5425	6773	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Pold2 as a novel interaction partner of protein inhibitor of activated STAT2 .
19574552	0	Poldip2	0,7	Nox4	30,34	Poldip2	Nox4	26073	50507	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Poldip2 , a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells .
23685359	0	Polo	11,15	BubR1	81,86	Polo	BubR1	40232(Tax:7227)	35522(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation .
15621805	0	Polo-Like_Kinase	14,30	PLK1	32,36	Polo-Like Kinase	PLK1	5347	5347	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Polo-Like_Kinase -LRB- PLK1 -RRB- in non-Hodgkin 's _ lymphomas .
26012549	0	Polo-Like_Kinase_1	33,51	Cep192	80,86	Polo-Like Kinase 1	Cep192	5347	55125	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Bimodal Interaction of Mammalian Polo-Like_Kinase_1 and a Centrosomal Scaffold , Cep192 , in the Regulation of Bipolar Spindle Formation .
26090465	0	Polo-Like_Kinase_1	93,111	MicroRNA3686	4,16	Polo-Like Kinase 1	MicroRNA3686	5347	100500839	Gene	Gene	Targeting|dobj|START_ENTITY Inhibits|advcl|Targeting Inhibits|nsubj|END_ENTITY	The MicroRNA3686 Inhibits the Proliferation of Pancreas_Carcinoma Cell Line by Targeting the Polo-Like_Kinase_1 .
25346190	0	Polo-Like_Kinase_1	129,147	Plk1	149,153	Polo-Like Kinase 1	Plk1	5347	5347	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Ligand-Based Pharmacophore Modeling , Atom-Based 3D-QSAR and Molecular Docking Studies on Substituted Thiazoles and Thiophenes as Polo-Like_Kinase_1 -LRB- Plk1 -RRB- Inhibitors .
19390576	0	Polo-like_kinase-1	0,18	Aurora_A	28,36	Polo-like kinase-1	Aurora A	5347	6790	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|destruction destruction|compound|END_ENTITY	Polo-like_kinase-1 controls Aurora_A destruction by activating APC/C-Cdh 1 .
19833129	0	Polo-like_kinase-1	0,18	MDM2	34,38	Polo-like kinase-1	MDM2	5347	4193	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Polo-like_kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover .
18615013	0	Polo-like_kinase-1	0,18	aurora_A	35,43	Polo-like kinase-1	aurora A	5347	6790	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Polo-like_kinase-1 is activated by aurora_A to promote checkpoint recovery .
21474997	0	Polo-like_kinase_1	0,18	AMP-activated_protein_kinase	43,71	Polo-like kinase 1	AMP-activated protein kinase	5347	5563	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Polo-like_kinase_1 regulates activation of AMP-activated_protein_kinase -LRB- AMPK -RRB- at the mitotic apparatus .
26745677	0	Polo-like_kinase_1	0,18	BRCA1	28,33	Polo-like kinase 1	BRCA1	5347	672	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Polo-like_kinase_1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks .
20823068	0	Polo-like_kinase_1	22,40	Bora	7,11	Polo-like kinase 1	Bora	5347	79866	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	SPAT-1 / Bora acts with Polo-like_kinase_1 to regulate PAR polarity and cell cycle progression .
15616186	0	Polo-like_kinase_1	61,79	Cep170	39,45	Polo-like kinase 1	Cep170	5347	9859	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The forkhead-associated domain protein Cep170 interacts with Polo-like_kinase_1 and serves as a marker for mature centrioles .
26459104	0	Polo-like_kinase_1	44,62	Emi2	36,40	Polo-like kinase 1	Emi2	5347	286151	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recognition of Emi2 by Polo-like_kinase_1 and development of peptidomimetics blocking oocyte maturation and fertilization .
15015605	0	Polo-like_kinase_1	0,18	PLK1	20,24	Polo-like kinase 1	PLK1	5347	5347	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Polo-like_kinase_1 -LRB- PLK1 -RRB- expression is associated with cell proliferative activity and cdc2 expression in malignant_lymphoma_of_the_thyroid .
22000864	0	Polo-like_kinase_1	36,54	PLK1	56,60	Polo-like kinase 1	PLK1	5347	5347	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Clinicopathological significance of Polo-like_kinase_1 -LRB- PLK1 -RRB- expression in human malignant_glioma .
22390279	0	Polo-like_kinase_1	0,18	PLK1	20,24	Polo-like kinase 1	PLK1	5347	5347	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Polo-like_kinase_1 -LRB- PLK1 -RRB- inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells .
21545375	0	Polo-like_kinase_1	74,92	Plk1	94,98	Polo-like kinase 1	Plk1	18817(Tax:10090)	18817(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Induction of antitumor immunity using dendritic cells electroporated with Polo-like_kinase_1 -LRB- Plk1 -RRB- mRNA in murine tumor models .
17360533	0	Polo-like_kinase_1	46,64	RhoA	89,93	Polo-like kinase 1	RhoA	5347	387	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Chemical genetics reveals the requirement for Polo-like_kinase_1 activity in positioning RhoA and triggering cytokinesis in human cells .
17635521	0	Polo-like_kinase_1	0,18	RhoA	29,33	Polo-like kinase 1	RhoA	5347	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Polo-like_kinase_1 regulates RhoA during cytokinesis exit in human cells .
21253604	0	Polo-like_kinase_1	48,66	YY1	25,28	Polo-like kinase 1	YY1	5347	7528	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The transcription factor YY1 is a substrate for Polo-like_kinase_1 at the G2/M transition of the cell cycle .
19001871	0	Polo-like_kinase_1	55,73	beta-catenin	18,30	Polo-like kinase 1	beta-catenin	5347	1499	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of beta-catenin as a novel substrate of Polo-like_kinase_1 .
11242082	0	Polo-like_kinase_1	0,18	cyclin_B1	34,43	Polo-like kinase 1	cyclin B1	380481(Tax:8355)	379888(Tax:8355)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Polo-like_kinase_1 phosphorylates cyclin_B1 and targets it to the nucleus during prophase .
25504441	0	Polo-like_kinase_1	72,90	mitotic_centromere-associated_kinesin	31,68	Polo-like kinase 1	mitotic centromere-associated kinesin	5347	11004	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The activity regulation of the mitotic_centromere-associated_kinesin by Polo-like_kinase_1 .
15024021	0	Polo-like_kinase_1	0,18	p53	35,38	Polo-like kinase 1	p53	5347	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|compound|END_ENTITY	Polo-like_kinase_1 -LRB- Plk1 -RRB- inhibits p53 function by physical interaction and phosphorylation .
16753148	0	Polo-like_kinase_1	0,18	p53	94,97	Polo-like kinase 1	p53	5347	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|mitotic_arrest mitotic_arrest|nmod|dephosphorylation dephosphorylation|nmod|END_ENTITY	Polo-like_kinase_1 regulates mitotic_arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation .
20577264	0	Polo-like_kinase_1	0,18	p53	90,93	Polo-like kinase 1	p53	5347	7157	Gene	Gene	phosphorylation|amod|START_ENTITY essential|nsubj|phosphorylation essential|nmod|inactivation inactivation|compound|END_ENTITY	Polo-like_kinase_1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery .
22184120	0	Polo-like_kinase_1	88,106	p53	68,71	Polo-like kinase 1	p53	5347	7157	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|protein protein|compound|END_ENTITY	Centrosomal_protein_55 -LRB- Cep55 -RRB- stability is negatively regulated by p53 protein through Polo-like_kinase_1 -LRB- Plk1 -RRB- .
22262171	0	Polo-like_kinase_1	50,68	p53	2,5	Polo-like kinase 1	p53	5347	7157	Gene	Gene	inhibitors|compound|START_ENTITY response|nmod|inhibitors relevant|nmod|response relevant|nsubj|END_ENTITY	p53 is not directly relevant to the response of Polo-like_kinase_1 inhibitors .
25714006	0	Polo-like_kinase_1	49,67	rictor	18,24	Polo-like kinase 1	rictor	5347	253260	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of rictor as a novel substrate of Polo-like_kinase_1 .
17706602	0	Polo-like_kinase_2	0,18	estrogen_receptor-related_receptor_gamma	79,119	Polo-like kinase 2	estrogen receptor-related receptor gamma	10769	2104	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Polo-like_kinase_2 gene expression is regulated by the orphan nuclear receptor estrogen_receptor-related_receptor_gamma -LRB- ERRgamma -RRB- .
24338472	0	Polo-like_kinase_2	0,18	tumor_necrosis_factor	66,87	Polo-like kinase 2	tumor necrosis factor	10769	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Polo-like_kinase_2 , a novel ADAM17 signaling component , regulates tumor_necrosis_factor a ectodomain shedding .
25267294	0	Polo-like_kinase_3	0,18	CtIP	29,33	Polo-like kinase 3	CtIP	1263	5932	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Polo-like_kinase_3 regulates CtIP during DNA double-strand break repair in G1 .
21402923	0	Polycomb	36,44	Bmi1	56,60	Polycomb	Bmi1	12416(Tax:10090)	648	Gene	Gene	gene|compound|START_ENTITY function|nmod|gene END_ENTITY|nsubj|function	An anticlastogenic function for the Polycomb Group gene Bmi1 .
25379404	0	Polycomb	4,12	Bmi1	22,26	Polycomb	Bmi1	12416(Tax:10090)	12151(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Polycomb protein , Bmi1 , regulates insulin sensitivity .
26802126	0	Polycomb	0,8	CBP	41,44	Polycomb	CBP	40358(Tax:7227)	1387	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain .
22896699	0	Polycomb	0,8	FOXP3	76,81	Polycomb	FOXP3	12416(Tax:10090)	20371(Tax:10090)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner .
10721694	0	Polycomb	45,53	MPc3	60,64	Polycomb	MPc3	12416(Tax:10090)	30951(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and analysis of a third mouse Polycomb gene , MPc3 .
26711264	0	Polycomb	8,16	RYBP	17,21	Polycomb	RYBP	12416(Tax:10090)	56353(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of Polycomb RYBP in Maintaining the B-1 to B-2 B-Cell Lineage Switch in Adult Hematopoiesis .
25634095	0	Polycomb	0,8	USP7	39,43	Polycomb	USP7	12416(Tax:10090)	252870(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis .
3081265	0	Polycomb	71,79	bithorax	39,47	Polycomb	bithorax	40358(Tax:7227)	42034(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila .
24137001	0	Polycomb-group_protein	41,63	microRNA-208b	12,25	Polycomb-group protein	microRNA-208b	211961(Tax:10090)	100124433(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The primary microRNA-208b interacts with Polycomb-group_protein , Ezh2 , to regulate gene expression in the heart .
8861097	0	Polycomb_group	72,86	Enx-1	51,56	Polycomb group	Enx-1	40358(Tax:7227)	14056(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Isolation and developmental expression analysis of Enx-1 , a novel mouse Polycomb_group gene .
9473645	0	Polycomb_group	40,54	Enx-2	67,72	Polycomb group	Enx-2	40358(Tax:7227)	14055(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and expression of a human/mouse Polycomb_group gene , ENX-2 / Enx-2 .
19666537	0	Polycomb_group	56,70	PcG	72,75	Polycomb group	PcG	40358(Tax:7227)	40358(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Drosophila O-GlcNAc transferase -LRB- OGT -RRB- is encoded by the Polycomb_group -LRB- PcG -RRB- gene , super sex combs -LRB- sxc -RRB- .
22411870	0	Polycomb_group_ring_finger_1	0,28	Runx1	45,50	Polycomb group ring finger 1	Runx1	84759	861	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Polycomb_group_ring_finger_1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells .
16452497	0	Polycystin-1	0,12	Akt	87,90	Polycystin-1	Akt	5310	207	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol_3-kinase / Akt signaling pathway .
22570239	0	Polycystin-1	0,12	CREB	55,59	Polycystin-1	CREB	18763(Tax:10090)	12912(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling : implications in ADPKD cell proliferation .
10504485	0	Polycystin-1	0,12	PKD1	27,31	Polycystin-1	PKD1	5310	5310	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Polycystin-1 expression in PKD1 , early-onset PKD1 , and TSC2/PKD1 cystic tissue .
24459142	0	Polycystin-1	0,12	Polycystin-2	34,46	Polycystin-1	Polycystin-2	5310	5311	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway .
17016857	0	Polycystin-1	0,12	Vesl-1	39,45	Polycystin-1	Vesl-1	18763(Tax:10090)	26556(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Polycystin-1 can interact with homer_1 / Vesl-1 in postnatal hippocampal neurons .
22570239	0	Polycystin-1	0,12	amphiregulin	23,35	Polycystin-1	amphiregulin	18763(Tax:10090)	11839(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling : implications in ADPKD cell proliferation .
18632682	0	Polycystin-1	0,12	beta-catenin	45,57	Polycystin-1	beta-catenin	5310	1499	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling .
11912216	0	Polycystin-1	0,12	c-Jun_N-terminal_kinase	27,50	Polycystin-1	c-Jun N-terminal kinase	5310	5599	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Polycystin-1 activation of c-Jun_N-terminal_kinase and AP-1 is mediated by heterotrimeric G proteins .
19491093	0	Polycystin-1	0,12	polycystin-2	49,61	Polycystin-1	polycystin-2	5310	5311	Gene	Gene	C-terminal|compound|START_ENTITY modulated|nsubjpass|C-terminal modulated|nmod|expression expression|amod|END_ENTITY	Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression .
25574838	0	Polycystin-1	0,12	polycystin-2	33,45	Polycystin-1	polycystin-2	18763(Tax:10090)	18764(Tax:10090)	Gene	Gene	maturation|amod|START_ENTITY requires|nsubj|maturation requires|xcomp|END_ENTITY	Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner .
26271513	0	Polycystin-2	40,52	Phosphoinositide_3-Kinase-C2a	0,29	Polycystin-2	Phosphoinositide 3-Kinase-C2a	18764(Tax:10090)	18704(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	Phosphoinositide_3-Kinase-C2a Regulates Polycystin-2 Ciliary Entry and Protects against Kidney_Cyst Formation .
24459142	0	Polycystin-2	34,46	Polycystin-1	0,12	Polycystin-2	Polycystin-1	5311	5310	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway .
16537653	0	Polycystin-2	0,12	polycystin-1	48,60	Polycystin-2	polycystin-1	5311	5310	Gene	Gene	traffics|nsubj|START_ENTITY traffics|nmod|cilia cilia|nmod|motif motif|amod|END_ENTITY	Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif .
23848298	0	Polycystin-2	0,12	polycystin-1	48,60	Polycystin-2	polycystin-1	5311	5310	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|change change|nmod|END_ENTITY	Polycystin-2 induces a conformational change in polycystin-1 .
20307692	0	Polyglutamine_tract-binding_protein-1	0,37	U5-15kD	47,54	Polyglutamine tract-binding protein-1	U5-15kD	10084	10907	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Polyglutamine_tract-binding_protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain .
26607151	0	Polymerase_Gamma	72,88	POLG	90,94	Polymerase Gamma	POLG	5428	5428	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	Pure Progressive Ataxia_and_Palatal_Tremor -LRB- PAPT -RRB- Associated with a New Polymerase_Gamma -LRB- POLG -RRB- Mutation .
26159783	0	Polymerase_b	95,107	MiR-499	0,7	Polymerase b	MiR-499	5423	574501	Gene	Gene	Enhances|nmod|START_ENTITY Enhances|nsubj|END_ENTITY	MiR-499 Enhances the Cisplatin Sensitivity of Esophageal_Carcinoma Cell Lines by Targeting DNA Polymerase_b .
8144033	0	Polymorphic_arylamine_N-acetyltransferase	0,41	NAT2	57,61	Polymorphic arylamine N-acetyltransferase	NAT2	101840555	101840555	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphic_arylamine_N-acetyltransferase encoding gene -LRB- NAT2 -RRB- from homozygous rapid and slow acetylator congenic Syrian_hamsters .
26293469	0	Polypyrimidine_Tract-Binding_Protein_1	83,121	Endothelial_Nitric_Oxide_Synthase	35,68	Polypyrimidine Tract-Binding Protein 1	Endothelial Nitric Oxide Synthase	5725	4846	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|Expression Expression|compound|END_ENTITY	Post-Transcriptional Regulation of Endothelial_Nitric_Oxide_Synthase Expression by Polypyrimidine_Tract-Binding_Protein_1 .
9563502	0	Polypyrimidine_tract-binding_protein	0,36	HnRNP_L	52,59	Polypyrimidine tract-binding protein	HnRNP L	5725	3191	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Polypyrimidine_tract-binding_protein interacts with HnRNP_L .
23536791	0	Polypyrimidine_tract-binding_protein	0,36	p19	45,48	Polypyrimidine tract-binding protein	p19	5725	1032	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Polypyrimidine_tract-binding_protein induces p19 -LRB- Ink4d -RRB- expression and inhibits the proliferation of H1299 cells .
17329592	0	Polypyrimidine_tract_binding_protein_2	0,38	phosphoglycerate_kinase_2	50,75	Polypyrimidine tract binding protein 2	phosphoglycerate kinase 2	56195(Tax:10090)	18663(Tax:10090)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|amod|END_ENTITY	Polypyrimidine_tract_binding_protein_2 stabilizes phosphoglycerate_kinase_2 mRNA in murine male germ cells by binding to its 3 ` UTR .
23217280	0	Polysaccharide-K	0,16	p21	33,36	Polysaccharide-K	p21	9344	1026	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Polysaccharide-K -LRB- PSK -RRB- increases p21 -LRB- WAF/Cip1 -RRB- and promotes apoptosis in pancreatic_cancer cells .
24756697	0	Polyserase-1	0,12	TMPRSS9	13,20	Polyserase-1	TMPRSS9	360200	360200	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Polyserase-1 / TMPRSS9 induces pro-tumor effects in pancreatic_cancer cells by activation of pro-uPA .
16014379	0	Pontin	49,55	Hint1	28,33	Pontin	Hint1	8607	3094	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription .
22290329	0	Popeye_domain_containing_2	4,30	popdc2	32,38	Popeye domain containing 2	popdc2	793666(Tax:7955)	793666(Tax:7955)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Popeye_domain_containing_2 -LRB- popdc2 -RRB- gene in zebrafish is required for heart and skeletal muscle development .
21185940	0	Porf-2	38,44	RhoGAP	4,10	Porf-2	RhoGAP	223666(Tax:10090)	75404(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The RhoGAP domain-containing protein , Porf-2 , inhibits proliferation and enhances apoptosis in neural stem cells .
18981224	0	Posterior_Sex_Combs	72,91	Suppressor_2_of_zeste	23,44	Posterior Sex Combs	Suppressor 2 of zeste	36431(Tax:7227)	36432(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Polycomb group protein Suppressor_2_of_zeste is a functional homolog of Posterior_Sex_Combs .
25590984	0	Postsynaptic_Density-95	93,116	PSD-95	118,124	Postsynaptic Density-95	PSD-95	116681(Tax:10116)	116681(Tax:10116)	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|END_ENTITY	Design , Synthesis , and Characterization of Fatty_Acid Derivatives of a Dimeric Peptide-Based Postsynaptic_Density-95 -LRB- PSD-95 -RRB- Inhibitor .
11861474	0	Pou2	75,79	Oct4	101,105	Pou2	Oct4	30333(Tax:7955)	5460	Gene	Gene	related|nsubj|START_ENTITY related|nmod|END_ENTITY	The zebrafish spiel-ohne-grenzen -LRB- spg -RRB- gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain , and for pre-gastrula morphogenesis .
24428937	0	Pou2f3	7,13	Skn-1a	0,6	Pou2f3	Skn-1a	18988(Tax:10090)	18988(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	Skn-1a / Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium .
15042710	0	Pou4f2	72,78	Brn-3b	64,70	Pou4f2	Brn-3b	402816(Tax:7955)	402816(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of the POU domain transcription factor Brn-3b -LRB- Pou4f2 -RRB- in the lateral line and visual system of zebrafish .
21402877	0	Pou4f3	42,48	Caprin-1	0,8	Pou4f3	Caprin-1	5459	4076	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Caprin-1 is a target of the deafness gene Pou4f3 and is recruited to stress granules in cochlear hair cells in response to ototoxic_damage .
17331196	0	Pou4f3	57,63	Lhx3	0,4	Pou4f3	Lhx3	18998(Tax:10090)	16871(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Lhx3 , a LIM domain transcription factor , is regulated by Pou4f3 in the auditory but not in the vestibular system .
26574507	0	Ppara	31,36	KLF5	16,20	Ppara	KLF5	19013(Tax:10090)	12224(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function .
12135475	0	Pph22p	57,63	PP2A	106,110	Pph22p	PP2A	851339(Tax:4932)	5524	Gene	Gene	different|nsubj|START_ENTITY different|nmod|END_ENTITY	The Saccharomyces_cerevisiae type 2A protein phosphatase Pph22p is biochemically different from mammalian PP2A .
24277933	0	Pph3	40,44	Mth1	64,68	Pph3	Mth1	5531	4521	Gene	Gene	targets|dobj|START_ENTITY targets|nmod|END_ENTITY	Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression .
24277933	0	Pph3	40,44	Psy2	0,4	Pph3	Psy2	5531	57223	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression .
25751141	0	Ppm1b	0,5	Rip3	65,69	Ppm1b	Rip3	19043(Tax:10090)	56532(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 .
9339378	0	Ppp1cc	89,95	protein_phosphatase_1c_gamma	59,87	Ppp1cc	protein phosphatase 1c gamma	19047(Tax:10090)	19047(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and functional analysis of the murine protein_phosphatase_1c_gamma -LRB- Ppp1cc -RRB- gene .
19819304	0	Ppp1r14c	16,24	KEPI	10,14	Ppp1r14c	KEPI	76142(Tax:10090)	76142(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of KEPI -LRB- Ppp1r14c -RRB- deletion on morphine analgesia and tolerance in mice of different genetic backgrounds : when a knockout is near a relevant quantitative trait locus .
16407978	0	Ppt1	16,20	Hsp90	73,78	Ppt1	Hsp90	853023(Tax:4932)	855836(Tax:4932)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90 .
25231727	0	PrLZ	23,27	EphA3	0,5	PrLZ	EphA3	7163	2042	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	EphA3 , induced by PC-1 / PrLZ , contributes to the malignant progression of prostate_cancer .
26011939	0	PrLZ	5,9	PC-1	0,4	PrLZ	PC-1	7163	7163	Gene	Gene	confers|nsubj|START_ENTITY END_ENTITY|appos|confers	PC-1 / PrLZ confers resistance to rapamycin in prostate_cancer cells through increased 4E-BP1 stability .
23419881	0	PrP	69,72	CD40	8,12	PrP	CD40	19122(Tax:10090)	21939(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CD40 in prion disease and the immune response to recombinant PrP .
18374587	0	PrP	24,27	Dab1	55,59	PrP	Dab1	19131(Tax:10090)	13131(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Fibrillar prion peptide PrP -LRB- 106-126 -RRB- treatment induces Dab1 phosphorylation and impairs APP processing and Abeta production in cortical neurons .
17446686	0	PrP	115,118	Doppel	135,141	PrP	Doppel	19122(Tax:10090)	26434(Tax:10090)	Gene	Gene	START_ENTITY|appos|independent independent|nmod|END_ENTITY	Serum withdrawal-induced apoptosis in ZrchI prion_protein -LRB- PrP -RRB- gene-deficient neuronal cell line is suppressed by PrP , independent of Doppel .
10930132	0	PrP	102,105	PrP	153,156	PrP	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of a novel gene encoding a PrP-like_protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene .
10930132	0	PrP	153,156	PrP	102,105	PrP	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of a novel gene encoding a PrP-like_protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene .
19796688	0	PrP	50,53	PrP	65,68	PrP	PrP	458076(Tax:9598)	19122(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Inducible expression of chimpanzee prion_protein -LRB- PrP -RRB- in murine PrP knock-out cells .
19796688	0	PrP	65,68	PrP	50,53	PrP	PrP	19122(Tax:10090)	458076(Tax:9598)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|appos|END_ENTITY	Inducible expression of chimpanzee prion_protein -LRB- PrP -RRB- in murine PrP knock-out cells .
23787697	0	PrP	24,27	PrP	34,37	PrP	PrP	281432(Tax:9913)	281432(Tax:9913)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of bovine T194A PrP -LRB- C -RRB- by PrP -LRB- Sc -RRB- - specific antibodies : potential implications for immunotherapy of familial_prion_diseases .
23787697	0	PrP	34,37	PrP	24,27	PrP	PrP	281432(Tax:9913)	281432(Tax:9913)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of bovine T194A PrP -LRB- C -RRB- by PrP -LRB- Sc -RRB- - specific antibodies : potential implications for immunotherapy of familial_prion_diseases .
11533027	0	PrP	23,26	Prion_protein	0,13	PrP	Prion protein	5621	5621	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Prion_protein fragment PrP - -LRB- 106-126 -RRB- induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells .
22440412	0	PrP	20,23	Prion_protein	0,13	PrP	Prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Prion_protein gene -LRB- PrP -RRB- polymorphisms in healthy sheep in Turkey .
15670743	0	PrP	0,3	STI1	20,24	PrP	STI1	5621	10963	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line .
2900718	0	PrP	28,31	Scrapie-associated_fibrils	0,26	PrP	Scrapie-associated fibrils	19122(Tax:10090)	74451(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Scrapie-associated_fibrils , PrP protein and the Sinc gene .
16953297	0	PrP	27,30	apolipoprotein_E	73,89	PrP	apolipoprotein E	5621	348	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	Recombinant neural protein PrP can bind with both recombinant and native apolipoprotein_E in vitro .
11160182	0	PrP	38,41	formyl_peptide_receptor-like_1	111,141	PrP	formyl peptide receptor-like 1	5621	2358	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	The neurotoxic prion peptide fragment PrP -LRB- 106-126 -RRB- is a chemotactic agonist for the G protein-coupled receptor formyl_peptide_receptor-like_1 .
7902706	0	PrP	73,76	insulin-like_growth_factor_I	37,65	PrP	insulin-like growth factor I	5621	3479	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Recombinant human growth hormone and insulin-like_growth_factor_I induce PrP gene expression in PC12 cells .
10400714	0	PrP	58,61	prion_protein	43,56	PrP	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Species-independent inhibition of abnormal prion_protein -LRB- PrP -RRB- formation by a peptide containing a conserved PrP sequence .
11385461	0	PrP	85,88	prion_protein	70,83	PrP	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Deletion of the alpha -LRB- 1,3 -RRB- galactosyl_transferase -LRB- GGTA1 -RRB- gene and the prion_protein -LRB- PrP -RRB- gene in sheep .
12041690	0	PrP	53,56	prion_protein	38,51	PrP	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphic distribution of the ovine prion_protein -LRB- PrP -RRB- gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie .
12514748	0	PrP	53,56	prion_protein	38,51	PrP	prion protein	5621	5621	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic characterization of the human prion_protein -LRB- PrP -RRB- gene locus .
12679034	0	PrP	36,39	prion_protein	16,29	PrP	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Soluble dimeric prion_protein binds PrP -LRB- Sc -RRB- in vivo and antagonizes prion disease .
17291697	0	PrP	43,46	prion_protein	28,41	PrP	prion protein	5621	5621	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparative analysis of the prion_protein -LRB- PrP -RRB- gene in cetacean species .
17498663	0	PrP	80,83	prion_protein	65,78	PrP	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Reduced response of splenocytes after mitogen-stimulation in the prion_protein -LRB- PrP -RRB- gene-deficient mouse : PrPLP/Doppel production and cerebral_degeneration .
18574558	0	PrP	43,46	prion_protein	28,41	PrP	prion protein	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and expression of a prion_protein -LRB- PrP -RRB- gene from Korean bovine -LRB- Bos_taurus coreanae -RRB- and production of rabbit anti-bovine PrP antibody .
19796688	0	PrP	50,53	prion_protein	35,48	PrP	prion protein	458076(Tax:9598)	458076(Tax:9598)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Inducible expression of chimpanzee prion_protein -LRB- PrP -RRB- in murine PrP knock-out cells .
19796688	0	PrP	65,68	prion_protein	35,48	PrP	prion protein	19122(Tax:10090)	458076(Tax:9598)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Inducible expression of chimpanzee prion_protein -LRB- PrP -RRB- in murine PrP knock-out cells .
19956715	0	PrP	63,66	prion_protein	48,61	PrP	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Implications of conflicting associations of the prion_protein -LRB- PrP -RRB- gene with scrapie susceptibility and fitness on the persistence of scrapie .
22144895	0	PrP	50,53	prion_protein	35,48	PrP	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Follicular dendritic cell-specific prion_protein -LRB- PrP -RRB- expression alone is sufficient to sustain prion infection in the spleen .
7494265	0	PrP	54,57	prion_protein	39,52	PrP	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	Accumulation|appos|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of proteinase K-resistant prion_protein -LRB- PrP -RRB- is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob_disease agent .
7815814	0	PrP	94,97	prion_protein	79,92	PrP	prion protein	5621	5621	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A simple and rapid method for sequencing the entire coding region of the human prion_protein -LRB- PrP -RRB- gene .
7902565	0	PrP	31,34	prion_protein	16,29	PrP	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Ablation of the prion_protein -LRB- PrP -RRB- gene in mice prevents scrapie and facilitates production of anti-PrP antibodies .
9031631	0	PrP	37,40	prion_protein	22,35	PrP	prion protein	100008658(Tax:9986)	100008658(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a prion_protein -LRB- PrP -RRB- gene from rabbit ; a species with apparent resistance to infection by prions .
9321385	0	PrP	56,59	prion_protein	41,54	PrP	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Astrocyte-specific expression of hamster prion_protein -LRB- PrP -RRB- renders PrP knockout mice susceptible to hamster scrapie .
25436888	0	PrP2	24,28	Prion_Protein	10,23	PrP2	Prion Protein	494129(Tax:7955)	19122(Tax:10090)	Gene	Gene	Migration|compound|START_ENTITY Migration|compound|END_ENTITY	Zebrafish Prion_Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development .
20964628	0	PrPC	15,19	Hsp70	0,5	PrPC	Hsp70	5621	3308	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Hsp70 binds to PrPC in the process of PrPC release via exosomes from THP-1 monocytes .
20964628	0	PrPC	38,42	Hsp70	0,5	PrPC	Hsp70	5621	3308	Gene	Gene	release|amod|START_ENTITY process|nmod|release binds|nmod|process binds|nsubj|END_ENTITY	Hsp70 binds to PrPC in the process of PrPC release via exosomes from THP-1 monocytes .
25437200	0	PrPC	38,42	Prion_Protein	23,36	PrPC	Prion Protein	5621	5621	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Functional Role of Prion_Protein -LRB- PrPC -RRB- on Autophagy .
15644272	0	PrPC	54,58	prion_protein	39,52	PrPC	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Mitochondrial localization of cellular prion_protein -LRB- PrPC -RRB- invokes neuronal_apoptosis in aged transgenic_mice overexpressing PrPC .
16825956	0	PrPC	49,53	prion_protein	34,47	PrPC	prion protein	5621	5621	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of prion_protein -LRB- PrPC -RRB- in the human forebrain during development .
16957924	0	PrPC	44,48	prion_protein	29,42	PrPC	prion protein	5621	5621	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of the cellular prion_protein -LRB- PrPC -RRB- in brains of livestock and domesticated species .
20926176	0	PrPC	52,56	prion_protein	37,50	PrPC	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and knockdown of cellular prion_protein -LRB- PrPC -RRB- in differentiating mouse embryonic stem cells .
26295309	0	PrPC	50,54	prion_protein	35,48	PrPC	prion protein	5621	5621	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Neuroprotective effect of cellular prion_protein -LRB- PrPC -RRB- is related with activation of alpha7 nicotinic acetylcholine receptor -LRB- a7nAchR -RRB- - mediated autophagy flux .
7595362	0	PrPC	34,38	prion_protein	19,32	PrPC	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	A cellular form of prion_protein -LRB- PrPC -RRB- exists in many non-neuronal tissues of sheep .
10971411	0	PrPc	35,39	prion_protein	20,33	PrPc	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Different levels of prion_protein -LRB- PrPc -RRB- expression on hamster , mouse and human blood cells .
15531106	0	PrPc	40,44	prion_protein	25,38	PrPc	prion protein	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of cellular prion_protein -LRB- PrPc -RRB- after focal cerebral_ischemia and influence of lesion severity .
17013787	0	PrPc	60,64	prion_protein	45,58	PrPc	prion protein	5621	281427(Tax:9913)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression and localization of the cellular prion_protein -LRB- PrPc -RRB- in the cow 's central nervous system .
17875293	0	PrPc	28,32	prion_protein	14,27	PrPc	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Functions of prion_protein PrPc -RSB- .
7788502	0	PrPc	56,60	prion_protein	41,54	PrPc	prion protein	5621	5621	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of cellular prion_protein -LRB- PrPc -RRB- in synaptic boutons of normal hamster hippocampus .
9506914	0	PrPc	83,87	prion_protein	68,81	PrPc	prion protein	5621	5621	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Distribution and submicroscopic immunogold localization of cellular prion_protein -LRB- PrPc -RRB- in extracerebral tissues .
9972829	0	PrPc	56,60	prion_protein	41,54	PrPc	prion protein	5621	5621	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of cellular prion_protein -LRB- PrPc -RRB- at the neuromuscular junction .
10198200	0	PrRP	81,85	prolactin-releasing_peptide	52,79	PrRP	prolactin-releasing peptide	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and characterization of immunoreactive prolactin-releasing_peptide -LRB- PrRP -RRB- in rat tissue and plasma .
10501562	0	PrRP	51,55	prolactin-releasing_peptide	22,49	PrRP	prolactin-releasing peptide	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Cytochemical study of prolactin-releasing_peptide -LRB- PrRP -RRB- in the rat brain .
11186069	0	PrRP	40,44	prolactin-releasing_peptide	11,38	PrRP	prolactin-releasing peptide	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of prolactin-releasing_peptide -LRB- PrRP -RRB- on sleep regulation in rats .
15620420	0	PrRP	49,53	prolactin-releasing_peptide	20,47	PrRP	prolactin-releasing peptide	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Nicotine stimulates prolactin-releasing_peptide -LRB- PrRP -RRB- cells and non-PrRP cells in the solitary nucleus .
17475403	0	PrRP	49,53	prolactin_releasing_peptide	20,47	PrRP	prolactin releasing peptide	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of brain prolactin_releasing_peptide -LRB- PrRP -RRB- changes in the estrous cycle of female rats .
16481321	0	Pragmin	0,7	RhoA	53,57	Pragmin	RhoA	157285	387	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Pragmin , a novel effector of Rnd2 GTPase , stimulates RhoA activity .
23900542	0	Prdm1a	0,6	foxd3	26,31	Prdm1a	foxd3	323473(Tax:7955)	30548(Tax:7955)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification .
23133405	0	Prdm9	53,58	Hst1	60,64	Prdm9	Hst1	213389(Tax:10090)	109727(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interallelic and intergenic incompatibilities of the Prdm9 -LRB- Hst1 -RRB- gene in mouse hybrid sterility .
25171874	0	Prdx6	86,91	nuclear_factor_erythroid_2-related_factor_2	14,57	Prdx6	nuclear factor erythroid 2-related factor 2	9588	4780	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Expression of nuclear_factor_erythroid_2-related_factor_2 -LRB- Nrf2 -RRB- and peroxiredoxin_6 -LRB- Prdx6 -RRB- proteins in healthy and pathologic placentas of human and rat .
25498756	0	Pre-B-Cell_Colony_Enhancing_Factor	39,73	Visfatin	74,82	Pre-B-Cell Colony Enhancing Factor	Visfatin	10113	10135	Gene	Gene	START_ENTITY|dep|Levels Levels|compound|END_ENTITY	Nicotinamide_Phosphoribosyltransferase / Pre-B-Cell_Colony_Enhancing_Factor / Visfatin Plasma Levels and Clinical Outcome in Patients With Dilated_Cardiomyopathy .
25516545	0	Pre-B_Cell_Colony_Enhancing_Factor	0,34	Insulin_Receptor	87,103	Pre-B Cell Colony Enhancing Factor	Insulin Receptor	10135	3643	Gene	Gene	Induces|nsubj|START_ENTITY Induces|dobj|Translocation Translocation|nmod|END_ENTITY	Pre-B_Cell_Colony_Enhancing_Factor -LRB- PBEF -RRB- Induces Nampt-Dependent Translocation of the Insulin_Receptor Out of Lipid Microdomains in A549 Lung Epithelial Cells .
19254573	0	Pref-1	0,6	Sox9	73,77	Pref-1	Sox9	13386(Tax:10090)	20682(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9 .
15146551	0	Pregnancy-associated_plasma_protein-A	0,37	PAPP-A	39,45	Pregnancy-associated plasma protein-A	PAPP-A	5069	5069	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- expression and insulin-like_growth_factor_binding_protein-4 protease activity in normal and malignant ovarian surface epithelial cells .
26297833	0	Pregnancy-associated_plasma_protein-A	0,37	parathyroid_hormone	72,91	Pregnancy-associated plasma protein-A	parathyroid hormone	18491(Tax:10090)	19226(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Pregnancy-associated_plasma_protein-A modulates the anabolic effects of parathyroid_hormone in mouse bone .
6611014	0	Pregnancy-specific_beta_1-glycoprotein	0,38	SP1	40,43	Pregnancy-specific beta 1-glycoprotein	SP1	6667	6667	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Pregnancy-specific_beta_1-glycoprotein -LRB- SP1 -RRB- levels measured by nephelometry in serum from women with vaginal_bleeding in the first half of pregnancy .
3096609	0	Pregnancy-specific_beta_1-glycoprotein	0,38	beta_2-microglobulin	100,120	Pregnancy-specific beta 1-glycoprotein	beta 2-microglobulin	6667	567	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Pregnancy-specific_beta_1-glycoprotein in serum in monoclonal_gammopathies : relationship with serum beta_2-microglobulin , and cellular origin .
10326620	0	Pregnancy-specific_glycoprotein	0,31	interleukin-10	98,112	Pregnancy-specific glycoprotein	interleukin-10	5673	3586	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|amod|END_ENTITY	Pregnancy-specific_glycoprotein gene expression in recurrent aborters : a potential correlation to interleukin-10 expression .
2110979	0	Pregnancy_zone_protein	0,22	interleukin-2	46,59	Pregnancy zone protein	interleukin-2	5858	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Pregnancy_zone_protein inhibits production of interleukin-2 but does not affect interleukin-2 receptor expression on T cell activation .
25381754	0	Pregnane_X_Receptor	82,101	CYP3A4	124,130	Pregnane X Receptor	CYP3A4	8856	1576	Gene	Gene	START_ENTITY|nmod|Prediction Prediction|nmod|Induction Induction|compound|END_ENTITY	Three-Dimensional Quantitative Structure-Activity Relationship Analysis for Human Pregnane_X_Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes : Structure-Based Comparative Molecular Field Analysis .
26232425	0	Pregnane_X_Receptor	0,19	HNF4a	30,35	Pregnane X Receptor	HNF4a	8856	3172	Gene	Gene	Gene|compound|START_ENTITY Gene|compound|END_ENTITY	Pregnane_X_Receptor Represses HNF4a Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells .
26232425	0	Pregnane_X_Receptor	0,19	IGFBP1	94,100	Pregnane X Receptor	IGFBP1	8856	3484	Gene	Gene	Gene|compound|START_ENTITY END_ENTITY|nsubj|Gene	Pregnane_X_Receptor Represses HNF4a Gene to Induce Insulin-Like Growth Factor-Binding Protein IGFBP1 that Alters Morphology of and Migrates HepG2 Cells .
20196838	0	Pregnane_X_Receptor	0,19	PXR	21,24	Pregnane X Receptor	PXR	8856	8856	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pregnane_X_Receptor -LRB- PXR -RRB- expression in colorectal_cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation .
25628225	0	Pregnane_X_Receptor	49,68	SLC13A5	0,7	Pregnane X Receptor	SLC13A5	8856	284111	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	SLC13A5 Is a Novel Transcriptional Target of the Pregnane_X_Receptor and Sensitizes Drug-Induced Steatosis in Human Liver .
23123212	0	Pregnane_X_receptor	0,19	Abcg2	48,53	Pregnane X receptor	Abcg2	8856	9429	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Pregnane_X_receptor upregulates ABC-transporter Abcg2 and Abcb1 at the blood-brain barrier .
23688499	0	Pregnane_X_receptor	0,19	C-1748	110,116	Pregnane X receptor	C-1748	8856	1035532(Tax:199310)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Pregnane_X_receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents , C-1748 and C-1305 , selectively diminished under hypoxia .
11336976	0	Pregnane_X_receptor	0,19	CYP3A	64,69	Pregnane X receptor	CYP3A	8856	1576	Gene	Gene	START_ENTITY|dep|basis basis|nmod|differences differences|nmod|induction induction|nummod|END_ENTITY	Pregnane_X_receptor : molecular basis for species differences in CYP3A induction by xenobiotics .
22982774	0	Pregnane_X_receptor	0,19	CYP3A	57,62	Pregnane X receptor	CYP3A	18171(Tax:10090)	13112(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Pregnane_X_receptor mediated-transcription regulation of CYP3A by glycyrrhizin : a possible mechanism for its hepatoprotective property against lithocholic_acid-induced injury .
17429319	0	Pregnane_X_receptor	0,19	CYP3A4	41,47	Pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	polymorphism|compound|START_ENTITY affects|nsubj|polymorphism affects|dobj|induction induction|nummod|END_ENTITY	Pregnane_X_receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid_receptor_coactivator-1 .
21459122	0	Pregnane_X_receptor	0,19	P-glycoprotein	46,60	Pregnane X receptor	P-glycoprotein	8856	5243	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Pregnane_X_receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells .
16940355	0	Pregnane_X_receptor	0,19	PXR	21,24	Pregnane X receptor	PXR	18171(Tax:10090)	18171(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Pregnane_X_receptor -LRB- PXR -RRB- activation : a mechanism for neuroprotection in a mouse model of Niemann-Pick_C_disease .
20538049	0	Pregnane_X_receptor	0,19	cytochrome_P450_3A4	78,97	Pregnane X receptor	cytochrome P450 3A4	8856	1576	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|down-regulation down-regulation|nmod|END_ENTITY	Pregnane_X_receptor is required for interleukin-6-mediated down-regulation of cytochrome_P450_3A4 in human hepatocytes .
16682417	0	Pregnane_X_receptor	0,19	farnesoid_X_receptor	35,55	Pregnane X receptor	farnesoid X receptor	18171(Tax:10090)	20186(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Pregnane_X_receptor is a target of farnesoid_X_receptor .
19365557	0	Prep1	12,17	4EHP	33,37	Prep1	4EHP	18771(Tax:10090)	326255(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation .
20106730	0	Prep1	0,5	Prep1	141,146	Prep1	Prep1	18771(Tax:10090)	18771(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Prep1 -LRB- pKnox1 -RRB- - deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc_lymphomagenesis : a tumor suppressor role for Prep1 .
20106730	0	Prep1	141,146	Prep1	0,5	Prep1	Prep1	18771(Tax:10090)	18771(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Prep1 -LRB- pKnox1 -RRB- - deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc_lymphomagenesis : a tumor suppressor role for Prep1 .
25597827	0	Preproinsulin	0,13	CD8	23,26	Preproinsulin	CD8	3630	925	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Preproinsulin specific CD8 + T cells in subjects with latent autoimmune diabetes show lower frequency and different pathophysiological characteristics than those with type_1_diabetes .
10349633	0	Presenilin	31,41	Notch	70,75	Presenilin	Notch	40260(Tax:7227)	31293(Tax:7227)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Drosophila Presenilin and its colocalization with Notch during development .
21195117	0	Presenilin-1	0,12	ErbB4	27,32	Presenilin-1	ErbB4	19164(Tax:10090)	13869(Tax:10090)	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation .
19920078	0	Presenilin-1	0,12	Id1	22,25	Presenilin-1	Id1	19164(Tax:10090)	15901(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner .
25394380	0	Presenilin-1	18,30	Pen2	39,43	Presenilin-1	Pen2	5663	55851	Gene	Gene	START_ENTITY|dep|Interaction Interaction|compound|END_ENTITY	G206D Mutation of Presenilin-1 Reduces Pen2 Interaction , Increases Ab42/Ab40 Ratio and Elevates ER Ca -LRB- 2 + -RRB- Accumulation .
11226248	0	Presenilin-1	0,12	epithelial_cadherin	31,50	Presenilin-1	epithelial cadherin	19164(Tax:10090)	12550(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Presenilin-1 binds cytoplasmic epithelial_cadherin , inhibits cadherin/p120 association , and regulates stability and function of the cadherin/catenin adhesion complex .
23794287	0	Presenilin-1	0,12	p62	41,44	Presenilin-1	p62	19164(Tax:10090)	18226(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation .
16449386	0	Presenilin-1	0,12	phospholipase_D1	18,34	Presenilin-1	phospholipase D1	5663	5337	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Presenilin-1 uses phospholipase_D1 as a negative regulator of beta-amyloid formation .
11201091	0	Presenilin-2	0,12	PS2	14,17	Presenilin-2	PS2	81751(Tax:10116)	81751(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Presenilin-2 -LRB- PS2 -RRB- expression up-regulation in a model of retinopathy of prematurity and pathoangiogenesis .
21841774	0	Presenilin_1	0,12	Akt	60,63	Presenilin 1	Akt	19164(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signaling signaling|compound|END_ENTITY	Presenilin_1 regulates homeostatic synaptic scaling through Akt signaling .
9153393	0	Presenilin_1	0,12	Notch1	29,35	Presenilin 1	Notch1	19164(Tax:10090)	18128(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Presenilin_1 is required for Notch1 and DII1 expression in the paraxial mesoderm .
26533827	0	Presenilin_1	49,61	Ps1	63,66	Presenilin 1	Ps1	5663	5663	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	A Study On Cytogenetic And Molecular Analysis Of Presenilin_1 -LRB- Ps1 -RRB- Gene In Alzheimer 's _ Disease .
18299393	0	Presenilin_1	0,12	acetylcholinesterase	28,48	Presenilin 1	acetylcholinesterase	19164(Tax:10090)	11423(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Presenilin_1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation .
10525535	0	Presenilin_1	0,12	amyloid_precursor_protein	52,77	Presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|processing processing|nmod|END_ENTITY	Presenilin_1 controls gamma-secretase processing of amyloid_precursor_protein in pre-golgi compartments of hippocampal neurons .
11406116	0	Presenilin_1	0,12	amyloid_precursor_protein	32,57	Presenilin 1	amyloid precursor protein	399258(Tax:8355)	398223(Tax:8355)	Gene	Gene	mutations|amod|START_ENTITY increase|nsubj|mutations increase|dobj|production production|compound|END_ENTITY	Presenilin_1 mutations increase amyloid_precursor_protein production and proteolysis in Xenopus_laevis oocytes .
11606587	0	Presenilin_1	0,12	beta-catenin	37,49	Presenilin 1	beta-catenin	5663	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Presenilin_1 independently regulates beta-catenin stability and transcriptional activity .
9689133	0	Presenilin_1	0,12	glycogen_synthase_kinase-3beta	29,59	Presenilin 1	glycogen synthase kinase-3beta	5663	2932	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Presenilin_1 associates with glycogen_synthase_kinase-3beta and its substrate tau .
17197080	0	Presenilin_1	19,31	p300	0,4	Presenilin 1	p300	5663	2033	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	p300 activation by Presenilin_1 but not by its M146L mutant .
12056836	0	Presenilin_1	45,57	p35	26,29	Presenilin 1	p35	5663	8851	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Cyclin-dependent_kinase-5 / p35 phosphorylates Presenilin_1 to regulate carboxy-terminal fragment stability .
26401782	0	Presenilin_1_and_2	59,77	Amyloid-b_Protein_Precursor	17,44	Presenilin 1 and 2	Amyloid-b Protein Precursor	29192;81751	54226(Tax:10116)	Gene	Gene	Genes|amod|START_ENTITY Genes|amod|END_ENTITY	Dysregulation of Amyloid-b_Protein_Precursor , b-Secretase , Presenilin_1_and_2 Genes in the Rat Selectively Vulnerable CA1 Subfield of Hippocampus Following Transient Global_Brain_Ischemia .
26984527	0	PrimPol	29,36	PolDIP2	0,7	PrimPol	PolDIP2	201973	26073	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities .
25436888	0	Prion_Protein	10,23	PrP2	24,28	Prion Protein	PrP2	19122(Tax:10090)	494129(Tax:7955)	Gene	Gene	Migration|compound|START_ENTITY Migration|compound|END_ENTITY	Zebrafish Prion_Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development .
25437200	0	Prion_Protein	23,36	PrPC	38,42	Prion Protein	PrPC	5621	5621	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Functional Role of Prion_Protein -LRB- PrPC -RRB- on Autophagy .
26975317	0	Prion_Protein	63,76	Tyrosine_Hydroxylase	14,34	Prion Protein	Tyrosine Hydroxylase	5621	7054	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Tyrosine_Hydroxylase is Negatively Regulated Via Prion_Protein .
15851519	0	Prion_protein	0,13	NCAM	45,49	Prion protein	NCAM	5621	4684	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Prion_protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth .
15477588	0	Prion_protein	0,13	PRNP	20,24	Prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prion_protein gene -LRB- PRNP -RRB- variants and evidence for strong purifying selection in functionally important regions of bovine exon 3 .
16622593	0	Prion_protein	0,13	PRNP	20,24	Prion protein	PRNP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prion_protein gene -LRB- PRNP -RRB- polymorphisms in Xinjiang local sheep breeds in China .
20140032	0	Prion_protein	0,13	PRNP	20,24	Prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prion_protein gene -LRB- PRNP -RRB- polymorphisms in native Chinese cattle .
11533027	0	Prion_protein	0,13	PrP	23,26	Prion protein	PrP	5621	5621	Gene	Gene	-|compound|START_ENTITY -|compound|END_ENTITY	Prion_protein fragment PrP - -LRB- 106-126 -RRB- induces apoptosis via mitochondrial disruption in human neuronal SH-SY5Y cells .
22440412	0	Prion_protein	0,13	PrP	20,23	Prion protein	PrP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prion_protein gene -LRB- PrP -RRB- polymorphisms in healthy sheep in Turkey .
25862412	0	Prion_protein	0,13	ZIP14	56,61	Prion protein	ZIP14	19122(Tax:10090)	213053(Tax:10090)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Prion_protein functions as a ferrireductase partner for ZIP14 and DMT1 .
22922482	0	Prion_protein	0,13	mPrP	14,18	Prion protein	mPrP	5621	19122(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Prion_protein mPrP -LSB- F175A -RSB- -LRB- 121-231 -RRB- : structure and stability in solution .
20615969	0	Prion_protein	0,13	stress-inducible_protein_1	31,57	Prion protein	stress-inducible protein 1	5621	10963	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Prion_protein interaction with stress-inducible_protein_1 enhances neuronal protein synthesis via mTOR .
12956961	0	Prk1p	28,33	Scd5p	55,60	Prk1p	Scd5p	854713(Tax:4932)	854507(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The actin-regulating kinase Prk1p negatively regulates Scd5p , a suppressor of clathrin deficiency , in actin organization and endocytosis .
11839092	0	Prkdc	96,101	DNA-PKcs	103,111	Prkdc	DNA-PKcs	395376(Tax:9031)	395376(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence analysis of 193.4 and 83.9 kbp of mouse and chicken genomic DNAs containing the entire Prkdc -LRB- DNA-PKcs -RRB- gene .
11280730	0	Prkdc	108,113	DNA-dependent_protein_kinase_catalytic_subunit	115,161	Prkdc	DNA-dependent protein kinase catalytic subunit	19090(Tax:10090)	19090(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Elevated breast_cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc -LRB- DNA-dependent_protein_kinase_catalytic_subunit -RRB- gene .
26851521	0	Prkdc	50,55	SCID	56,60	Prkdc	SCID	19090(Tax:10090)	19090(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Simple and reliable genotyping protocol for mouse Prkdc -LRB- SCID -RRB- mutation .
3091193	0	Prl	170,173	prolactin	159,168	Prl	prolactin	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	The effect of unilateral decortication on the patterns of pulsatile follicle stimulating hormone -LRB- FSH -RRB- and luteinizing hormone -LRB- LH -RRB- release and on mean plasma prolactin -LRB- Prl -RRB- levels in the ovariectomized rat .
16699504	0	Prmt5	23,28	Blimp1	0,6	Prmt5	Blimp1	27374(Tax:10090)	12142(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells .
15358521	0	Prnd	80,84	Doppel	101,107	Prnd	Doppel	26434(Tax:10090)	26434(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Identification of the critical cis-acting elements in the promoter of the mouse Prnd gene coding for Doppel protein .
16297464	0	Prnd	70,74	Doppel	91,97	Prnd	Doppel	26434(Tax:10090)	26434(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Involvement of upstream stimulatory factor in regulation of the mouse Prnd gene coding for Doppel protein .
12064254	0	Prnp	37,41	prion_protein	17,30	Prnp	prion protein	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Influence of the prion_protein gene , Prnp , on scrapie susceptibility in sheep .
10353846	0	Pro-1	0,5	macrophage_migration_inhibitory_factor	9,47	Pro-1	macrophage migration inhibitory factor	4000	4282	Gene	Gene	START_ENTITY|nmod|functions functions|compound|END_ENTITY	Pro-1 of macrophage_migration_inhibitory_factor functions as a catalytic base in the phenylpyruvate_tautomerase activity .
9765224	0	Pro-caspase-3	0,13	caspase-8	47,56	Pro-caspase-3	caspase-8	836	841	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Pro-caspase-3 is a major physiologic target of caspase-8 .
1572663	0	Pro-melanin-concentrating_hormone	0,33	PMCH	40,44	Pro-melanin-concentrating hormone	PMCH	5367	5367	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pro-melanin-concentrating_hormone gene -LRB- PMCH -RRB- is localized on human chromosome 12q and rat chromosome 7 .
7514797	0	Pro-opiomelanocortin	0,20	POMC	22,26	Pro-opiomelanocortin	POMC	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pro-opiomelanocortin -LRB- POMC -RRB- gene expression , as identified by in situ hybridization , in purified populations of interstitial macrophages and Leydig cells of the adult rat testis .
19190683	0	Pro-protein_convertase-2	0,24	carboxypeptidase-E	25,43	Pro-protein convertase-2	carboxypeptidase-E	5126	1363	Gene	Gene	START_ENTITY|parataxis|mediated mediated|nsubj|END_ENTITY	Pro-protein_convertase-2 / carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia .
7595540	0	Pro-thyrotropin-releasing_hormone	0,33	PC1	60,63	Pro-thyrotropin-releasing hormone	PC1	25569(Tax:10116)	85496(Tax:10116)	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Pro-thyrotropin-releasing_hormone processing by recombinant PC1 .
25926675	0	Pro1	44,48	Ly49	32,36	Pro1	Ly49	19125(Tax:10090)	17055(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The distal upstream promoter in Ly49 genes , Pro1 , is active in mature NK cells and T cells , does not require TATA boxes , and displays enhancer activity .
25283153	0	Pro1	65,69	growth_hormone-releasing_hormone	22,54	Pro1	growth hormone-releasing hormone	4000	2691	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Identification of the growth_hormone-releasing_hormone analogue -LSB- Pro1 , Val14 -RSB- - hGHRH with an incomplete C-term amidation in a confiscated product .
23117360	0	ProGRP	110,116	Pro_gastrin-releasing_peptide	78,107	ProGRP	Pro gastrin-releasing peptide	2922	2922	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Benign pulmonary mass suspected of primary lung_cancer for the high level of Pro_gastrin-releasing_peptide ProGRP -RSB- .
24723213	0	ProGRP	62,68	pro-gastrin_releasing_peptide	31,60	ProGRP	pro-gastrin releasing peptide	2922	2922	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Reference intervals for plasma pro-gastrin_releasing_peptide -LRB- ProGRP -RRB- levels in healthy adults of Chinese Han ethnicity .
18410445	0	ProL1	20,25	opiorphin	4,13	ProL1	opiorphin	58503	58503	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The opiorphin gene -LRB- ProL1 -RRB- and its homologues function in erectile physiology .
23117360	0	Pro_gastrin-releasing_peptide	78,107	ProGRP	110,116	Pro gastrin-releasing peptide	ProGRP	2922	2922	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Benign pulmonary mass suspected of primary lung_cancer for the high level of Pro_gastrin-releasing_peptide ProGRP -RSB- .
10562449	0	Proadrenomedullin_N-terminal_20_peptide	0,39	PAMP	41,45	Proadrenomedullin N-terminal 20 peptide	PAMP	133	133	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Proadrenomedullin_N-terminal_20_peptide -LRB- PAMP -RRB- immunoreactivity in vertebrate juxtaglomerular granular cells identified by both light and electron microscopy .
8687431	0	Proadrenomedullin_N-terminal_20_peptide	0,39	neutral_endopeptidase	62,83	Proadrenomedullin N-terminal 20 peptide	neutral endopeptidase	133	4311	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Proadrenomedullin_N-terminal_20_peptide is rapidly cleaved by neutral_endopeptidase .
19255251	0	Probasin	0,8	ID1	39,42	Probasin	ID1	54192(Tax:10090)	15901(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Probasin promoter-driven expression of ID1 is not sufficient for carcinogenesis in rodent prostate .
18164932	0	Procollagen_C-proteinase_enhancer-1	0,35	beta2-microglobulin	60,79	Procollagen C-proteinase enhancer-1	beta2-microglobulin	5118	567	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Procollagen_C-proteinase_enhancer-1 -LRB- PCPE-1 -RRB- interacts with beta2-microglobulin -LRB- beta2-m -RRB- and may help initiate beta2-m amyloid fibril formation in connective tissues .
16849556	0	Proepithelin	0,12	ERK1/2	100,106	Proepithelin	ERK1/2	2896	5595;5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Proepithelin promotes migration and invasion of 5637 bladder_cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex .
25447542	0	Profilin1	56,65	mDia1	7,12	Profilin1	mDia1	18643(Tax:10090)	13367(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Formin mDia1 , a downstream molecule of FMNL1 , regulates Profilin1 for actin assembly and spindle organization during mouse oocyte meiosis .
21755480	0	Progesterone-Induced_Blocking_Factor	8,44	PIBF	1,5	Progesterone-Induced Blocking Factor	PIBF	10464	10464	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|dep|-RSB-	-LSB- PIBF - Progesterone-Induced_Blocking_Factor -RSB- .
16393965	0	Progesterone-induced_blocking_factor	0,36	STAT6	47,52	Progesterone-induced blocking factor	STAT6	10464	6778	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Progesterone-induced_blocking_factor activates STAT6 via binding to a novel IL-4 receptor .
26183411	0	Progesterone_Receptor	0,21	ERa	33,36	Progesterone Receptor	ERa	5241	26284	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Progesterone_Receptor Determines ERa Function .
26286601	0	Progesterone_Receptor	0,21	PGR	23,26	Progesterone Receptor	PGR	5241	5241	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Progesterone_Receptor -LRB- PGR -RRB- gene polymorphism is associated with susceptibility to preterm_birth .
11668223	0	Progesterone_receptor	0,21	BRCA1	63,68	Progesterone receptor	BRCA1	5241	672	Gene	Gene	variant|compound|START_ENTITY increases|nsubj|variant increases|dobj|risk risk|nmod|carriers carriers|compound|END_ENTITY	Progesterone_receptor variant increases ovarian_cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives .
17785366	0	Progesterone_receptor	0,21	Bcl-2	32,37	Progesterone receptor	Bcl-2	5241	596	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Progesterone_receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine_leiomyoma cells .
26153859	0	Progesterone_receptor	0,21	ERa	32,35	Progesterone receptor	ERa	5241	26284	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|action action|compound|END_ENTITY	Progesterone_receptor modulates ERa action in breast_cancer .
26245370	0	Progesterone_receptor	13,34	ERa	45,48	Progesterone receptor	ERa	5241	26284	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|action action|compound|END_ENTITY	Corrigendum : Progesterone_receptor modulates ERa action in breast_cancer .
25479686	0	Progesterone_receptor	0,21	GATA3	47,52	Progesterone receptor	GATA3	5241	2625	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	Progesterone_receptor activation downregulates GATA3 by transcriptional repression and increased_protein_turnover promoting breast_tumor growth .
9178756	0	Progesterone_receptor	0,21	IGFBP-1	96,103	Progesterone receptor	IGFBP-1	5241	3484	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Progesterone_receptor -LRB- PR -RRB- inhibits expression of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- in human endometrial cell line HEC-1B : characterization of the inhibitory effect of PR on the distal promoter region of the IGFBP-1 gene .
22457812	0	Progesterone_receptor	0,21	Msx2	32,36	Progesterone receptor	Msx2	5241	4488	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Progesterone_receptor activates Msx2 expression by downregulating TNAP/Akp2 and activating the Bmp pathway in EpH4 mouse mammary epithelial cells .
24014651	0	Progesterone_receptor	0,21	RANKL	61,66	Progesterone receptor	RANKL	18667(Tax:10090)	21943(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Progesterone_receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells .
23640331	0	Progesterone_receptor	0,21	bcl-x	30,35	Progesterone receptor	bcl-x	5241	598	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Progesterone_receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation .
22348324	0	Progesterone_receptor	0,21	breast_cancer_resistance_protein	36,68	Progesterone receptor	breast cancer resistance protein	5241	9429	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Progesterone_receptor downregulates breast_cancer_resistance_protein expression via binding to the progesterone response element in breast_cancer .
16467118	0	Progesterone_receptor	0,21	epidermal_growth_factor_receptor_2	49,83	Progesterone receptor	epidermal growth factor receptor 2	5241	2064	Gene	Gene	loss|amod|START_ENTITY correlates|nsubj|loss correlates|nmod|overexpression overexpression|amod|END_ENTITY	Progesterone_receptor loss correlates with human epidermal_growth_factor_receptor_2 overexpression in estrogen_receptor-positive breast_cancer .
12743151	0	Progesterone_receptor	0,21	estrogen_receptor	76,93	Progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	status|amod|START_ENTITY improves|nsubj|status improves|dobj|prediction prediction|nmod|status status|compound|END_ENTITY	Progesterone_receptor status significantly improves outcome prediction over estrogen_receptor status alone for adjuvant endocrine therapy in two large breast_cancer databases .
25778292	0	Progesterone_receptor	0,21	estrogen_receptor	61,78	Progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	START_ENTITY|advcl|determining determining|dobj|prognosis prognosis|nmod|patients patients|amod|positive positive|amod|END_ENTITY	Progesterone_receptor status in determining the prognosis of estrogen_receptor positive / HER2 negative breast_carcinoma patients .
10499541	0	Progesterone_receptor	0,21	prolactin	41,50	Progesterone receptor	prolactin	5241	5617	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Progesterone_receptor regulates decidual prolactin expression in differentiating human endometrial stromal cells .
20019164	0	Progesterone_receptor_A	0,23	VIP	33,36	Progesterone receptor A	VIP	100462900	100735454	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inhibition inhibition|compound|END_ENTITY	Progesterone_receptor_A mediates VIP inhibition of contraction .
24680695	0	Progesterone_receptor_membrane_component_1	0,42	PGRMC1	44,50	Progesterone receptor membrane component 1	PGRMC1	10857	10857	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Progesterone_receptor_membrane_component_1 -LRB- PGRMC1 -RRB- expression in fetal membranes among women with preterm premature_rupture of the membranes -LRB- PPROM -RRB- .
23441172	0	Programmed_Cell_Death_4	106,129	miR-21	0,6	Programmed Cell Death 4	miR-21	27250	406991	Gene	Gene	involving|dobj|START_ENTITY cells|acl|involving transition|nmod|cells promotes|nsubj|transition promotes|dep|END_ENTITY	miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed_Cell_Death_4 and Sprouty-1 .
25027060	0	Programmed_Death-1	12,30	PD-1	32,36	Programmed Death-1	PD-1	18566(Tax:10090)	18566(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Role of the Programmed_Death-1 -LRB- PD-1 -RRB- pathway in regulation of Theiler 's murine encephalomyelitis virus-induced demyelinating_disease .
26408698	0	Programmed_Death-1_Ligand-1	0,27	PDL1	29,33	Programmed Death-1 Ligand-1	PDL1	29126	29126	Gene	Gene	Expression|amod|START_ENTITY Expression|appos|END_ENTITY	Programmed_Death-1_Ligand-1 -LRB- PDL1 -RRB- Expression Is Associated with the Prognosis of Patients with Stage_II / III_Gastric_Cancer .
26707870	0	Programmed_Death-ligand_1	21,46	Hypoxia-inducible_Factor-2_Alpha	71,103	Programmed Death-ligand 1	Hypoxia-inducible Factor-2 Alpha	29126	2034	Gene	Gene	START_ENTITY|appos|Target Target|nmod|END_ENTITY	Renal_Cell_Carcinoma Programmed_Death-ligand_1 , a New Direct Target of Hypoxia-inducible_Factor-2_Alpha , is Regulated by von_Hippel-Lindau Gene Mutation Status .
25803808	0	Programmed_Death_1	0,18	CD4	46,49	Programmed Death 1	CD4	18566(Tax:10090)	404704(Tax:9823)	Gene	Gene	Regulates|compound|START_ENTITY Memory|nsubj|Regulates Memory|dobj|Accumulation Accumulation|compound|END_ENTITY	Programmed_Death_1 Regulates Memory Phenotype CD4 T Cell Accumulation , Inhibits Expansion of the Effector Memory Phenotype Subset and Modulates Production of Effector Cytokines .
26314420	0	Programmed_Death_Ligand-1	15,40	PD-L1	42,47	Programmed Death Ligand-1	PD-L1	29126	29126	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of Programmed_Death_Ligand-1 -LRB- PD-L1 -RRB- in Human Acute Leukemia and Its Clinical Significance -RSB- .
20702469	0	Programmed_cell_death_4	0,23	PDCD4	25,30	Programmed cell death 4	PDCD4	27250	27250	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Programmed_cell_death_4 -LRB- PDCD4 -RRB- expression during multistep Barrett 's _ carcinogenesis .
23049623	0	Programmed_cell_death_4	0,23	Pdcd4	25,30	Programmed cell death 4	Pdcd4	27250	27250	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Programmed_cell_death_4 -LRB- Pdcd4 -RRB- expression in colorectal_adenocarcinoma : Association with clinical stage .
25820028	0	Programmed_cell_death_4	0,23	Pdcd4	33,38	Programmed cell death 4	Pdcd4	27250	27250	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Programmed_cell_death_4 protein -LRB- Pdcd4 -RRB- and homeodomain-interacting_protein_kinase_2 -LRB- Hipk2 -RRB- antagonistically control translation of Hipk2 mRNA .
17991735	0	Programmed_cell_death_4	0,23	miR-21	82,88	Programmed cell death 4	miR-21	27250	406991	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Programmed_cell_death_4 -LRB- PDCD4 -RRB- is an important functional target of the microRNA miR-21 in breast_cancer cells .
26798582	0	Programmed_cell_death_protein-1	0,31	programmed_cell_death_ligand-1	32,62	Programmed cell death protein-1	programmed cell death ligand-1	100513601	29126	Gene	Gene	START_ENTITY|dep|pathway pathway|amod|END_ENTITY	Programmed_cell_death_protein-1 / programmed_cell_death_ligand-1 pathway inhibition and predictive biomarkers : understanding transforming_growth_factor-beta role .
19318582	0	Programmed_cell_death_protein_4	0,31	Y-box_binding_protein-1	47,70	Programmed cell death protein 4	Y-box binding protein-1	27250	4904	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Programmed_cell_death_protein_4 down-regulates Y-box_binding_protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth .
26221374	0	Programmed_death-1	0,18	PD-1	20,24	Programmed death-1	PD-1	5133	5133	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Programmed_death-1 -LRB- PD-1 -RRB- polymorphism is associated with gastric_cardia_adenocarcinoma .
26221374	0	Programmed_death-1	0,18	PD-1	20,24	Programmed death-1	PD-1	5133	5133	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Programmed_death-1 -LRB- PD-1 -RRB- polymorphism is associated with gastric_cardia_adenocarcinoma .
26885204	0	Programmed_death-1	0,18	PD-1	20,24	Programmed death-1	PD-1	5133	5133	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Programmed_death-1 -LRB- PD-1 -RRB- rs2227981 C > T polymorphism is associated with cancer susceptibility : a meta-analysis .
26892362	0	Progranulin	0,11	CXCL9	58,63	Progranulin	CXCL9	14824(Tax:10090)	17329(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner .
22316048	0	Progranulin	0,11	GP88	13,17	Progranulin	GP88	2896	2896	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Progranulin -LRB- GP88 -RRB- tumor tissue expression is associated with increased risk of recurrence in breast_cancer patients diagnosed with estrogen receptor positive invasive_ductal_carcinoma .
21204008	0	Progranulin	0,11	GSK-3b	82,88	Progranulin	GSK-3b	2896	2932	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3b .
18848708	0	Progranulin	0,11	PGRN	13,17	Progranulin	PGRN	2896	2896	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Progranulin -LRB- PGRN -RRB- expression in ALS : an immunohistochemical study .
17210807	0	Progranulin	0,11	PPA1	58,62	Progranulin	PPA1	2896	5464	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	Progranulin mutations in primary progressive aphasia : the PPA1 and PPA3 families .
24703938	0	Progranulin	0,11	TNFR2	104,109	Progranulin	TNFR2	2896	7133	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2 .
12065415	0	Prohibitin	0,10	Brg-1	20,25	Prohibitin	Brg-1	5245	6597	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth .
17873902	0	Prohibitin	0,10	RNF2	26,30	Prohibitin	RNF2	5245	6045	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Prohibitin interacts with RNF2 and regulates E2F1 function via dual pathways .
19725029	0	Prohibitin	0,10	TGF-beta	21,29	Prohibitin	TGF-beta	5245	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|apoptosis apoptosis|amod|END_ENTITY	Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and - independent signaling .
14500729	0	Prohibitin	0,10	p53	51,54	Prohibitin	p53	5245	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|nmod|END_ENTITY	Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling .
25719244	0	Prohibitin_1	19,31	Akt	0,3	Prohibitin 1	Akt	5245	207	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt phosphorylates Prohibitin_1 to mediate its mitochondrial localization and promote proliferation of bladder_cancer cells .
24522204	0	Prohibitin_2	0,12	AKT	40,43	Prohibitin 2	AKT	11331	207	Gene	Gene	represents|nsubj|START_ENTITY represents|dobj|substrate substrate|compound|END_ENTITY	Prohibitin_2 represents a novel nuclear AKT substrate during all-trans_retinoic_acid-induced differentiation of acute_promyelocytic_leukemia cells .
25811241	0	Prohormone_Convertase_2	55,78	7B2	44,47	Prohormone Convertase 2	7B2	5126	6447	Gene	Gene	Activation|compound|START_ENTITY Activation|nummod|END_ENTITY	Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone_Convertase_2 Activation .
4738897	0	Proinsulin	1,11	proinsulin	19,29	Proinsulin	proinsulin	397415(Tax:9823)	397415(Tax:9823)	Gene	Gene	START_ENTITY|dep|-RSB- -RSB-|compound|END_ENTITY	-LSB- Proinsulin -- swine proinsulin -RSB- .
19540198	0	Proinsulin	0,10	protein_tyrosine_phosphatase_1B	38,69	Proinsulin	protein tyrosine phosphatase 1B	3630	5770	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Proinsulin C-peptide interaction with protein_tyrosine_phosphatase_1B demonstrated with a labeling reaction .
16289056	0	Prointerleukin-16	22,39	Kip1	48,52	Prointerleukin-16	Kip1	3603	1027	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of nuclear Prointerleukin-16 and p27 -LRB- Kip1 -RRB- in primary human T lymphocytes .
19103522	0	Prokineticin_1	0,14	CCL4	23,27	Prokineticin 1	CCL4	84432	6351	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Prokineticin_1 induces CCL4 , CXCL1 and CXCL8 in human monocytes but not in macrophages and dendritic cells .
21546446	0	Prokineticin_1	0,14	Dickkopf_1	23,33	Prokineticin 1	Dickkopf 1	84432	22943	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prokineticin_1 induces Dickkopf_1 expression and regulates cell proliferation and decidualization in the human endometrium .
27066093	0	Prolactin	0,9	BCL6	19,23	Prolactin	BCL6	5617	604	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Prolactin Inhibits BCL6 Expression in Breast_Cancer Cells through a MicroRNA-339-5p-Dependent Pathway .
26970274	0	Prolactin	0,9	BRCA1	67,72	Prolactin	BRCA1	5617	672	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	Prolactin inhibits a major tumor-suppressive function of wild type BRCA1 .
12114648	0	Prolactin	49,58	Basic_Fibroblast_Growth_Factor	0,30	Prolactin	Basic Fibroblast Growth Factor	5617	2247	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Basic_Fibroblast_Growth_Factor Expression by Two Prolactin and Thyrotropin-Producing Pituitary_Adenomas .
22159143	0	Prolactin	0,9	CD4	25,28	Prolactin	CD4	5617	920	Gene	Gene	/|compound|START_ENTITY /|compound|END_ENTITY	Prolactin down-regulates CD4 + CD25hiCD127low / - regulatory T cell function in humans .
24064365	0	Prolactin	0,9	ERa	20,23	Prolactin	ERa	19109(Tax:10090)	13982(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Prolactin activates ERa in the absence of ligand in female mammary development and carcinogenesis in vivo .
25193864	0	Prolactin	0,9	ERa	156,159	Prolactin	ERa	5617	26284	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cross-talk cross-talk|nmod|END_ENTITY	Prolactin induces up-regulation of its cognate receptor in breast_cancer cells via transcriptional activation of its generic promoter by cross-talk between ERa and STAT5 .
19769948	0	Prolactin	0,9	Egr-1	18,23	Prolactin	Egr-1	24683(Tax:10116)	24330(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Prolactin induces Egr-1 gene expression in cultured hypothalamic cells and in the rat hypothalamus .
15568616	0	Prolactin	0,9	IL-8	20,24	Prolactin	IL-8	5617	3576	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|compound|END_ENTITY	Prolactin modulates IL-8 production induced by porins or LPS through different signaling mechanisms .
21457752	0	Prolactin	0,9	Jak2	18,22	Prolactin	Jak2	5617	3717	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Prolactin induces Jak2 phosphorylation of RUSHY195 .
18653779	0	Prolactin	0,9	Janus_kinase_2	48,62	Prolactin	Janus kinase 2	19109(Tax:10090)	16452(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|dobj|interact interact|nmod|END_ENTITY	Prolactin and ErbB4/HER4 signaling interact via Janus_kinase_2 to induce mammary epithelial cell gene expression differentiation .
22392353	0	Prolactin	0,9	Janus_kinase_2	52,66	Prolactin	Janus kinase 2	5617	3717	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Prolactin promotes hepatocellular_carcinoma through Janus_kinase_2 .
6788946	0	Prolactin	0,9	LH-RH	40,45	Prolactin	LH-RH	443317(Tax:9940)	443529(Tax:9940)	Gene	Gene	release|nsubj|START_ENTITY release|nmod|response response|nmod|END_ENTITY	Prolactin and LH release in response to LH-RH and TRH in ewes during dioestrus , pregnancy and post partum .
18392683	0	Prolactin	0,9	MFG-E8	18,24	Prolactin	MFG-E8	5617	4240	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Prolactin induces MFG-E8 production in macrophages via transcription factor C/EBPbeta-dependent pathway .
26305039	0	Prolactin	29,38	Occludin	49,57	Prolactin	Occludin	24683(Tax:10116)	83497(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Psychological Stress-Derived Prolactin Modulates Occludin Expression in Vaginal Epithelial Cells to Compromise Barrier Function .
26305039	0	Prolactin	29,38	Occludin	49,57	Prolactin	Occludin	24683(Tax:10116)	83497(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Psychological Stress-Derived Prolactin Modulates Occludin Expression in Vaginal Epithelial Cells to Compromise Barrier Function .
19415692	0	Prolactin	0,9	PI3-K	79,84	Prolactin	PI3-K	5617	5293	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Prolactin induces chitotriosidase expression in human macrophages through PTK , PI3-K , and MAPK pathways .
2759338	0	Prolactin	0,9	PRL	11,14	Prolactin	PRL	5617	5617	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Prolactin -LRB- PRL -RRB- mRNA from human decidua differs from pituitary PRL mRNA but resembles the IM-9-P3 lymphoblast PRL transcript .
19481553	0	Prolactin	0,9	STAT5	41,46	Prolactin	STAT5	24683(Tax:10116)	24918(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Prolactin induces phosphorylation of the STAT5 in adrenal glands of Hatano rats during stress .
9581833	0	Prolactin	0,9	Stat1	20,25	Prolactin	Stat1	5617	6772	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Prolactin activates Stat1 but does not antagonize Stat1 activation and growth inhibition by type I interferons in human breast_cancer cells .
11133161	0	Prolactin	0,9	Stat5	64,69	Prolactin	Stat5	19109(Tax:10090)	20850(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Prolactin , growth_hormone , and epidermal_growth_factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects .
12060651	0	Prolactin	0,9	Stat5	41,46	Prolactin	Stat5	5617	6776	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Prolactin induces SHP-2 association with Stat5 , nuclear translocation , and binding to the beta-casein gene promoter in mammary cells .
15885880	0	Prolactin	0,9	Stat5	22,27	Prolactin	Stat5	5617	6776	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Prolactin signals via Stat5 and Oct-1 to the proximal cyclin_D1 promoter .
7925280	0	Prolactin	0,9	Stat5	47,52	Prolactin	Stat5	5617	6776	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|Tyr694 Tyr694|nmod|END_ENTITY	Prolactin induces phosphorylation of Tyr694 of Stat5 -LRB- MGF -RRB- , a prerequisite for DNA binding and induction of transcription .
416208	0	Prolactin	0,9	TRF	32,35	Prolactin	TRF	5617	7013	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to synthetic TRF in pregnant ewes .
1673063	0	Prolactin	0,9	TRH	48,51	Prolactin	TRH	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to submaximal stimulation by TRH in nonaffective psychoses .
3093910	0	Prolactin	0,9	TRH	30,33	Prolactin	TRH	5617	7200	Gene	Gene	response|nsubj|START_ENTITY response|xcomp|END_ENTITY	Prolactin and TSH response to TRH and metoclopramide before and after l-thyroxine therapy in subclinical_hypothyroidism .
3917409	0	Prolactin	0,9	TRH	53,56	Prolactin	TRH	5617	7200	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with hypothalamic-pituitary_disease .
8874842	0	Prolactin	0,9	TRH	31,34	Prolactin	TRH	5617	7200	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Prolactin and TSH responses to TRH and to ECT in pre - and postmenopausal women with major_depression .
16885226	0	Prolactin	0,9	TRPV1	20,25	Prolactin	TRPV1	24683(Tax:10116)	83810(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Prolactin modulates TRPV1 in female rat trigeminal sensory neurons .
24022869	0	Prolactin	0,9	TRPV1	20,25	Prolactin	TRPV1	5617	7442	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Prolactin regulates TRPV1 , TRPA1 , and TRPM8 in sensory neurons in a sex-dependent manner : Contribution of prolactin_receptor to inflammatory_pain .
19494234	0	Prolactin	0,9	ZNT2	20,24	Prolactin	ZNT2	5617	7780	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells .
16849835	0	Prolactin	45,54	adiponectin	64,75	Prolactin	adiponectin	5617	9370	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Hypoadiponectinemia in lean lactating women : Prolactin inhibits adiponectin secretion from human adipocytes .
12865345	0	Prolactin	0,9	annexin_5	19,28	Prolactin	annexin 5	24683(Tax:10116)	25673(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Prolactin inhibits annexin_5 expression and apoptosis in the corpus luteum of pseudopregnant rats : involvement of local gonadotropin-releasing_hormone .
8547445	0	Prolactin	0,9	buspirone	22,31	Prolactin	prolactin	5617	5617	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to buspirone challenge in the presence of dopaminergic blockade .
11043575	0	Prolactin	0,9	c-jun_N-terminal_kinase	35,58	Prolactin	c-jun N-terminal kinase	24683(Tax:10116)	116554(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Prolactin stimulates activation of c-jun_N-terminal_kinase -LRB- JNK -RRB- .
15234536	0	Prolactin	0,9	chitotriosidase	18,33	Prolactin	chitotriosidase	5617	1118	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prolactin induces chitotriosidase gene expression in human monocyte-derived macrophages .
19415692	0	Prolactin	0,9	chitotriosidase	18,33	Prolactin	chitotriosidase	5617	1118	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Prolactin induces chitotriosidase expression in human macrophages through PTK , PI3-K , and MAPK pathways .
15885880	0	Prolactin	0,9	cyclin_D1	54,63	Prolactin	cyclin D1	5617	595	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|promoter promoter|amod|END_ENTITY	Prolactin signals via Stat5 and Oct-1 to the proximal cyclin_D1 promoter .
22658484	0	Prolactin	0,9	cyclin_D1	59,68	Prolactin	cyclin D1	19109(Tax:10090)	12443(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Prolactin promotes mammary pathogenesis independently from cyclin_D1 .
3921411	0	Prolactin	0,9	gonadotropin-releasing_hormone	25,55	Prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response after gonadotropin-releasing_hormone in the polycystic_ovary_syndrome .
5529569	0	Prolactin	0,9	growth_hormone	45,59	Prolactin	growth hormone	5617	2688	Gene	Gene	START_ENTITY|dep|evidence evidence|dep|separate separate|nmod|END_ENTITY	Prolactin : evidence that it is separate from growth_hormone in human blood .
6412497	0	Prolactin	0,9	growth_hormone	76,90	Prolactin	growth hormone	5617	2688	Gene	Gene	responses|compound|START_ENTITY responses|nmod|thyroliberin thyroliberin|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Prolactin and thyrotrophin responses to thyroliberin -LRB- TRH -RRB- in patients with growth_hormone deficiency : study in 167 patients .
7851719	0	Prolactin	0,9	growth_hormone	11,25	Prolactin	growth hormone	396453(Tax:9031)	378781(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prolactin , growth_hormone , and luteinizing hormone-beta subunit gene expression in the cephalic and caudal lobes of the anterior pituitary gland during embryogenesis and different reproductive stages in the chicken .
2516347	0	Prolactin	1,10	growth_hormone_releasing_hormone	47,79	Prolactin	growth hormone releasing hormone	5617	2691	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	-LSB- Prolactin response to acute administration of growth_hormone_releasing_hormone in patients with uremia -RSB- .
12788307	0	Prolactin	0,9	interferon-gamma	33,49	Prolactin	interferon-gamma	5617	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Prolactin enhances production of interferon-gamma , interleukin-12 , and interleukin-10 , but not of tumor_necrosis_factor-alpha , in a stimulus-specific manner .
11022129	0	Prolactin	0,9	interferon_regulatory_factor-1	20,50	Prolactin	interferon regulatory factor-1	24683(Tax:10116)	24508(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Prolactin activates interferon_regulatory_factor-1 expression in normal lympho-hemopoietic cells .
17088410	0	Prolactin	0,9	leptin	18,24	Prolactin	leptin	280901(Tax:9913)	280836(Tax:9913)	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|action action|compound|END_ENTITY	Prolactin affects leptin action in the bovine mammary gland via the mammary fat pad .
1824680	0	Prolactin	0,9	luteinizing_hormone-releasing_hormone	67,104	Prolactin	luteinizing hormone-releasing hormone	5617	2796	Gene	Gene	values|amod|START_ENTITY values|nmod|END_ENTITY	Prolactin and pituitary gonadotropin values and responses to acute luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- challenge in patients having long-term treatment with a depot LHRH analogue .
6347662	0	Prolactin	0,9	luteinizing_hormone-releasing_hormone	83,120	Prolactin	luteinizing hormone-releasing hormone	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|xcomp|luteinizing luteinizing|xcomp|END_ENTITY	Prolactin suppresses luteinizing hormone secretion and pituitary responsiveness to luteinizing_hormone-releasing_hormone by a direct action at the anterior pituitary .
3156383	0	Prolactin	0,9	ornithine_decarboxylase	25,48	Prolactin	ornithine decarboxylase	19109(Tax:10090)	18263(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Prolactin stimulation of ornithine_decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol_myristate_acetate -LRB- TPA -RRB- , a protein kinase C activator , stimulates ornithine_decarboxylase -LRB- ODC -RRB- activity in mammary gland explants derived from 12-14 day pregnant mice .
3582728	0	Prolactin	0,9	ornithine_decarboxylase	33,56	Prolactin	ornithine decarboxylase	24683(Tax:10116)	24609(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Prolactin selectively stimulates ornithine_decarboxylase in the lateral lobe of the rat prostate .
9460655	0	Prolactin	0,9	p59fyn	46,52	Prolactin	p59fyn	24683(Tax:10116)	25150(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells .
6149694	0	Prolactin	0,9	parathyroid_hormone	25,44	Prolactin	parathyroid hormone	280901(Tax:9913)	280903(Tax:9913)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|secretion secretion|amod|END_ENTITY	Prolactin stimulation of parathyroid_hormone secretion in bovine parathyroid cells .
7263847	0	Prolactin	0,9	parathyroid_hormone	38,57	Prolactin	parathyroid hormone	5617	5741	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|nsubj|responses	Prolactin and calcitonin responses to parathyroid_hormone infusion in hypoparathyroid , pseudohypoparathyroid , and normal subjects .
1475014	0	Prolactin	0,9	pro-opiomelanocortin	24,44	Prolactin	pro-opiomelanocortin	24683(Tax:10116)	24664(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Prolactin regulation of pro-opiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus .
11403105	0	Prolactin	0,9	prolactin_receptor	67,85	Prolactin	prolactin receptor	5617	5618	Gene	Gene	analysis|nummod|START_ENTITY analysis|nmod|END_ENTITY	Prolactin binding analysis and immunohistochemical localization of prolactin_receptor in porcine ovarian cells .
21775057	0	Prolactin	0,9	prolactin_receptor	82,100	Prolactin	prolactin receptor	5617	5618	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|survival survival|dep|importance importance|nmod|type type|compound|END_ENTITY	Prolactin increases survival and migration of ovarian_cancer cells : importance of prolactin_receptor type and therapeutic potential of S179D and G129R receptor antagonists .
24022869	0	Prolactin	0,9	prolactin_receptor	106,124	Prolactin	prolactin receptor	5617	5618	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|Contribution Contribution|nmod|END_ENTITY	Prolactin regulates TRPV1 , TRPA1 , and TRPM8 in sensory neurons in a sex-dependent manner : Contribution of prolactin_receptor to inflammatory_pain .
26567005	0	Prolactin	0,9	prolactin_receptor	55,73	Prolactin	prolactin receptor	19109(Tax:10090)	19116(Tax:10090)	Gene	Gene	transport|compound|START_ENTITY independent|nsubj|transport independent|nmod|END_ENTITY	Prolactin transport into mouse brain is independent of prolactin_receptor .
9723866	0	Prolactin	0,9	prolactin_receptor	127,145	Prolactin	prolactin receptor	100750601	100757415	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|expressing expressing|dobj|END_ENTITY	Prolactin induces an inward current through voltage-independent Ca2 + channels in Chinese_hamster_ovary cells stably expressing prolactin_receptor .
20962042	0	Prolactin	0,9	pyruvate_kinase_M2	31,49	Prolactin	pyruvate kinase M2	5617	5315	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Prolactin inhibits activity of pyruvate_kinase_M2 to stimulate cell proliferation .
1672662	0	Prolactin	0,9	secretin	22,30	Prolactin	secretin	5617	6343	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nsubj|response	Prolactin response to secretin during the spontaneous menstrual cycle in women .
16123156	0	Prolactin	0,9	signal_transducer_and_activator_of_transcription_5b	33,84	Prolactin	signal transducer and activator of transcription 5b	24683(Tax:10116)	25126(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Prolactin specifically activates signal_transducer_and_activator_of_transcription_5b in neuroendocrine dopaminergic neurons .
3930271	0	Prolactin	0,9	thyrotropin-releasing-hormone	38,67	Prolactin	thyrotropin-releasing-hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin and thyrotropin response to thyrotropin-releasing-hormone in adolescent females with insulin-treated diabetes_mellitus .
117409	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in normal and complicated late pregnancies .
12244566	0	Prolactin	0,9	thyrotropin-releasing_hormone	99,128	Prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY change|nsubj|secretion change|nmod|subpopulations subpopulations|acl|stimulated stimulated|nmod|END_ENTITY	Prolactin secretion and intracellular Ca -LRB- 2 + -RRB- change in rat lactotroph subpopulations stimulated by thyrotropin-releasing_hormone .
16484326	0	Prolactin	0,9	thyrotropin-releasing_hormone	33,62	Prolactin	thyrotropin-releasing hormone	19109(Tax:10090)	22044(Tax:10090)	Gene	Gene	secretion|nsubj|START_ENTITY secretion|nmod|mice mice|nmod|deficiency deficiency|amod|END_ENTITY	Prolactin secretion in mice with thyrotropin-releasing_hormone deficiency .
1906673	0	Prolactin	0,9	thyrotropin-releasing_hormone	23,52	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Prolactin responses to thyrotropin-releasing_hormone in multi-infarct_dementia and senile_dementia of the Alzheimer_type .
3094215	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in early and advanced human breast_cancer .
3106094	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|nsubj|START_ENTITY response|xcomp|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in women with infertility and/or randomly elevated serum prolactin levels .
3917409	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with hypothalamic-pituitary_disease .
3922866	0	Prolactin	0,9	thyrotropin-releasing_hormone	38,67	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin and thyrotropin response to thyrotropin-releasing_hormone in premenopausal women with fibrocystic_disease of the breast .
6233752	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in children with gynecomastia , premature_thelarche and idiopathic_precocious_puberty .
6420042	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|stimulation stimulation|amod|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone stimulation and dopaminergic inhibition in benign_breast_disease .
6425749	0	Prolactin	0,9	thyrotropin-releasing_hormone	39,68	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|nsubj|responses	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone during the peripartal period .
6434573	0	Prolactin	0,9	thyrotropin-releasing_hormone	39,68	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone and metoclopramide in men with chronic alcoholism .
6807677	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in children with Turner 's _ syndrome and hyperthyroidism .
6811338	0	Prolactin	0,9	thyrotropin-releasing_hormone	42,71	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	hyperstimulation|nsubj|START_ENTITY hyperstimulation|xcomp|END_ENTITY	Prolactin hyperstimulation in response to thyrotropin-releasing_hormone in patients with endometriosis .
819453	0	Prolactin	0,9	thyrotropin-releasing_hormone	39,68	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone in patients with secondary amenorrhea : the effect of bromocriptine .
9433398	0	Prolactin	0,9	thyrotropin-releasing_hormone	22,51	Prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nsubj|response	Prolactin response to thyrotropin-releasing_hormone as a guideline for cyclical mastalgia treatment .
12788307	0	Prolactin	0,9	tumor_necrosis_factor-alpha	98,125	Prolactin	tumor necrosis factor-alpha	5617	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Prolactin enhances production of interferon-gamma , interleukin-12 , and interleukin-10 , but not of tumor_necrosis_factor-alpha , in a stimulus-specific manner .
9705972	0	Prolactin-inducible_protein	52,79	gross_cystic_disease_fluid_protein-15	14,51	Prolactin-inducible protein	gross cystic disease fluid protein-15	5304	5304	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of gross_cystic_disease_fluid_protein-15 / Prolactin-inducible_protein in rat salivary glands .
9516478	0	Prolactin_receptor	0,18	Stat5	29,34	Prolactin receptor	Stat5	5618	6776	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Prolactin_receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways .
8584023	0	Prolactin_receptor	0,18	c-src_kinase	38,50	Prolactin receptor	c-src kinase	24684(Tax:10116)	315707(Tax:10116)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Prolactin_receptor is associated with c-src_kinase in rat liver .
11675469	0	Prolactin_receptor	0,18	prolactin_receptor	65,83	Prolactin receptor	prolactin receptor	5618	5618	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Prolactin_receptor gene expression and immunolocalization of the prolactin_receptor in human luteinized granulosa cells .
18669642	0	Prolactin_receptor-associated_protein	0,37	Hsd17b7	87,94	Prolactin receptor-associated protein	Hsd17b7	20200(Tax:10090)	15490(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prolactin_receptor-associated_protein / 17beta-hydroxysteroid dehydrogenase type 7 gene -LRB- Hsd17b7 -RRB- plays a crucial role in embryonic development and fetal survival .
23983595	0	Prolidase	0,9	matrix_metalloproteinases_1_and_13	11,45	Prolidase	matrix metalloproteinases 1 and 13	5184	4312;4322	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Prolidase , matrix_metalloproteinases_1_and_13 activity , oxidative-antioxidative status as a marker of preterm premature rupture_of_membranes and chorioamnionitis in maternal vaginal washing fluids .
15705097	0	Proliferating-cell_nuclear_antigen	0,34	PCNA	127,131	Proliferating-cell nuclear antigen	PCNA	5111	5111	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Proliferating-cell_nuclear_antigen -LRB- PCNA -RRB- as an independent prognostic marker in patients after prostatectomy : a comparison of PCNA and Ki-67 .
20336191	0	Proliferating_Cell_Nuclear_Antigen	23,57	Nucleolin	0,9	Proliferating Cell Nuclear Antigen	Nucleolin	5111	4691	Gene	Gene	Binds|nmod|START_ENTITY Binds|nsubj|END_ENTITY	Nucleolin Binds to the Proliferating_Cell_Nuclear_Antigen and Inhibits Nucleotide Excision Repair .
23201573	0	Proliferating_Cell_Nuclear_Antigen	35,69	PCNA	71,75	Proliferating Cell Nuclear Antigen	PCNA	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation at tyrosine 114 of Proliferating_Cell_Nuclear_Antigen -LRB- PCNA -RRB- is required for adipogenesis in response to high fat diet .
9177181	0	Proliferating_cell_nuclear_antigen	0,34	DNA_polymerase_delta	93,113	Proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Proliferating_cell_nuclear_antigen promotes DNA synthesis past template lesions by mammalian DNA_polymerase_delta .
11578374	0	Proliferating_cell_nuclear_antigen	0,34	PCNA	36,40	Proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- immunoreactivity in ovarian_serous_and_mucinous_neoplasms : diagnostic and prognostic value .
16584090	0	Proliferating_cell_nuclear_antigen	0,34	PCNA	36,40	Proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in pituitary_adenomas : relationship to the endocrine phenotype of adenoma .
7520574	0	Proliferating_cell_nuclear_antigen	0,34	PCNA	36,40	Proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression of megakaryocytopoiesis in normal human bone marrow and reactive lesions with special emphasis on HIV-myelopathy .
8105046	0	Proliferating_cell_nuclear_antigen	0,34	PCNA	36,40	Proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression as a prognostic indicator for renal_cell_carcinoma : comparison with tumour grade , mitotic index , and silver-staining nucleolar organizer region numbers .
8907001	0	Proliferating_cell_nuclear_antigen	0,34	PCNA	36,40	Proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in oral_squamous_cell_carcinoma - an aid to conventional histological grading ?
16118211	0	Proliferating_cell_nuclear_antigen	0,34	Xic1	78,82	Proliferating cell nuclear antigen	Xic1	394328(Tax:8355)	100137657(Tax:8355)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Proliferating_cell_nuclear_antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching .
2884260	0	Proliferating_cell_nuclear_antigen	0,34	cyclin	42,48	Proliferating cell nuclear antigen	cyclin	5111	5111	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- / cyclin in activated human T lymphocytes .
7912140	0	Proliferating_cell_nuclear_antigen	0,34	cyclin	35,41	Proliferating cell nuclear antigen	cyclin	5111	5111	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Proliferating_cell_nuclear_antigen / cyclin expression in small adenomas of the large intestine in relation to size and macroscopic appearance .
8422109	0	Proliferating_cell_nuclear_antigen	0,34	cyclin	36,42	Proliferating cell nuclear antigen	cyclin	5111	5111	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- cyclin -RRB- expression in normal and abnormal cervical squamous_epithelia .
7982468	0	Proliferating_cell_nuclear_antigen	0,34	cyclin_D1	102,111	Proliferating cell nuclear antigen	cyclin D1	5111	595	Gene	Gene	sites|amod|START_ENTITY sites|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Proliferating_cell_nuclear_antigen bound to DNA synthesis sites : phosphorylation and association with cyclin_D1 and cyclin_A .
17625704	0	Proliferating_cell_nuclear_antigen	0,34	p53	43,46	Proliferating cell nuclear antigen	p53	5111	7157	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- , p53 and MDM2 expression in Hodgkins_disease .
12784255	0	Prolin-rich_tyrosine_kinase_2	0,29	PYK2	31,35	Prolin-rich tyrosine kinase 2	PYK2	19229(Tax:10090)	19229(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prolin-rich_tyrosine_kinase_2 -LRB- PYK2 -RRB- expression and localization in mouse testis .
9366396	0	Proline-rich_tyrosine_kinase-2	0,30	paxillin	117,125	Proline-rich tyrosine kinase-2	paxillin	2185	5829	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Proline-rich_tyrosine_kinase-2 activation by beta_1_integrin fibronectin receptor cross-linking and association with paxillin in human natural killer cells .
11916084	0	Proline-rich_tyrosine_kinase_2	0,30	vWF	116,119	Proline-rich tyrosine kinase 2	vWF	2185	7450	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Proline-rich_tyrosine_kinase_2 and focal_adhesion_kinase are involved in different phases of platelet activation by vWF .
26562260	0	Prolyl_Hydroxylase_Domain-Containing_Protein_2	24,70	Phd2	72,76	Prolyl Hydroxylase Domain-Containing Protein 2	Phd2	112405(Tax:10090)	112405(Tax:10090)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Conditional Deletion of Prolyl_Hydroxylase_Domain-Containing_Protein_2 -LRB- Phd2 -RRB- Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation .
22948157	0	Prolyl_hydroxylase_3	0,20	tumor_necrosis_factor-a	59,82	Prolyl hydroxylase 3	tumor necrosis factor-a	112399	7124	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	Prolyl_hydroxylase_3 -LRB- PHD3 -RRB- modulates catabolic effects of tumor_necrosis_factor-a -LRB- TNF-a -RRB- on cells of the nucleus pulposus through co-activation of nuclear factor kB -LRB- NF-kB -RRB- / p65 signaling .
24581673	0	Prolyl_hydroxylase_domain-2	0,27	PHD2	29,33	Prolyl hydroxylase domain-2	PHD2	54583	54583	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Prolyl_hydroxylase_domain-2 -LRB- PHD2 -RRB- inhibition may be a better therapeutic strategy in renal_anemia .
19332125	0	Prolyl_oligopeptidase	0,21	GAP-43	31,37	Prolyl oligopeptidase	GAP-43	19072(Tax:10090)	14432(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Prolyl_oligopeptidase binds to GAP-43 and functions without its peptidase activity .
23161076	0	Prominin-1	19,29	CD133	31,36	Prominin-1	CD133	8842	8842	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Gene Regulation of Prominin-1 -LRB- CD133 -RRB- in Normal and Cancerous Tissues .
23161081	0	Prominin-1	29,39	CD133	22,27	Prominin-1	CD133	19126(Tax:10090)	19126(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	New Insights into the CD133 -LRB- Prominin-1 -RRB- Expression in Mouse and Human Colon_Cancer Cells .
7623123	0	Promyelocyte_Leukemia_Zinc_Finger	33,66	PLZF	68,72	Promyelocyte Leukemia Zinc Finger	PLZF	235320(Tax:10090)	235320(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Developmental analysis of murine Promyelocyte_Leukemia_Zinc_Finger -LRB- PLZF -RRB- gene expression : implications for the neuromeric model of the forebrain organization .
16835227	0	Promyelocytic_leukemia	0,22	Chk2	33,37	Promyelocytic leukemia	Chk2	5371	11200	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Promyelocytic_leukemia activates Chk2 by mediating Chk2 autophosphorylation .
16835227	0	Promyelocytic_leukemia	0,22	Chk2	51,55	Promyelocytic leukemia	Chk2	5371	11200	Gene	Gene	activates|nsubj|START_ENTITY activates|advcl|mediating mediating|dobj|autophosphorylation autophosphorylation|amod|END_ENTITY	Promyelocytic_leukemia activates Chk2 by mediating Chk2 autophosphorylation .
22589541	0	Promyelocytic_leukemia_protein	0,30	tumor_necrosis_factor_a	111,134	Promyelocytic leukemia protein	tumor necrosis factor a	5371	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Promyelocytic_leukemia_protein -LRB- PML -RRB- regulates endothelial cell network formation and migration in response to tumor_necrosis_factor_a -LRB- TNFa -RRB- and interferon a -LRB- IFNa -RRB- .
10773688	0	Prop-1	62,68	PROP1	75,80	Prop-1	PROP1	474647(Tax:9615)	474647(Tax:9615)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning , characterization , and physical mapping of the canine Prop-1 gene -LRB- PROP1 -RRB- : exclusion as a candidate for combined_pituitary_hormone_deficiency in German shepherd dogs .
26668321	0	Proprotein_Convertase_Subtilisin_Kexin_Type_9	52,97	PCSK9	99,104	Proprotein Convertase Subtilisin Kexin Type 9	PCSK9	255738	255738	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Suppressor_of_Cytokine_Signaling-3 -LRB- SOCS-3 -RRB- induces Proprotein_Convertase_Subtilisin_Kexin_Type_9 -LRB- PCSK9 -RRB- expression in hepatic HepG2 cell line .
26668321	0	Proprotein_Convertase_Subtilisin_Kexin_Type_9	52,97	Suppressor_of_Cytokine_Signaling-3	0,34	Proprotein Convertase Subtilisin Kexin Type 9	Suppressor of Cytokine Signaling-3	255738	9021	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Suppressor_of_Cytokine_Signaling-3 -LRB- SOCS-3 -RRB- induces Proprotein_Convertase_Subtilisin_Kexin_Type_9 -LRB- PCSK9 -RRB- expression in hepatic HepG2 cell line .
9738875	0	Pros45	32,38	SUG1	55,59	Pros45	SUG1	33105(Tax:7227)	33105(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Cloning and characterization of Pros45 , the Drosophila SUG1 proteasome subunit homolog .
25320454	0	Prosaposin	0,10	Q10	30,33	Prosaposin	Q10	5660	27161	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	Prosaposin regulates coenzyme Q10 levels in HepG2 cells , especially those in mitochondria .
9403694	0	Prospero	16,24	Miranda	0,7	Prospero	Miranda	41363(Tax:7227)	42379(Tax:7227)	Gene	Gene	directs|dobj|START_ENTITY directs|nsubj|END_ENTITY	Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions .
21436036	0	Prospero-related_homeobox_1	0,27	Prox1	34,39	Prospero-related homeobox 1	Prox1	5629	5629	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prospero-related_homeobox_1 gene -LRB- Prox1 -RRB- is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis .
22982861	0	Prospero-related_homeobox_1	45,72	TWIST1	30,36	Prospero-related homeobox 1	TWIST1	5629	7291	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	Transcriptional repression of TWIST1 gene by Prospero-related_homeobox_1 inhibits invasiveness of hepatocellular_carcinoma cells .
23045246	0	Prospero_homeobox_1	0,19	E-cadherin	99,109	Prospero homeobox 1	E-cadherin	5629	999	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	Prospero_homeobox_1 promotes epithelial-mesenchymal transition in colon_cancer cells by inhibiting E-cadherin via miR-9 .
15889150	0	Prostaglandin_D2	0,16	SOX9	70,74	Prostaglandin D2	SOX9	5730	6662	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|import import|nmod|END_ENTITY	Prostaglandin_D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation .
26585956	0	Prostaglandin_E_synthase	0,24	Gas6	43,47	Prostaglandin E synthase	Gas6	64292(Tax:10090)	14456(Tax:10090)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Prostaglandin_E_synthase is upregulated by Gas6 during cancer-induced venous_thrombosis .
19670249	0	Prostasin	0,9	iNOS	20,24	Prostasin	iNOS	5652	51477	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Prostasin regulates iNOS and cyclin_D1 expression by modulating protease-activated_receptor-2 signaling in prostate epithelial cells .
16638913	0	Prostasin	0,9	inducible_nitric_oxide_synthase	21,52	Prostasin	inducible nitric oxide synthase	5652	18126(Tax:10090)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|expression expression|amod|END_ENTITY	Prostasin attenuates inducible_nitric_oxide_synthase expression in lipopolysaccharide-induced urinary bladder_inflammation .
20414405	0	Prostate-Specific_Antigen	73,98	PSA	100,103	Prostate-Specific Antigen	PSA	354	354	Gene	Gene	Levels|compound|START_ENTITY Levels|appos|END_ENTITY	Outcome of Prostate Biopsy in Men Younger than 40 Years of Age with High Prostate-Specific_Antigen -LRB- PSA -RRB- Levels .
21221201	0	Prostate-Specific_Antigen	36,61	PSA	63,66	Prostate-Specific Antigen	PSA	354	354	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Association of Polymorphisms in the Prostate-Specific_Antigen -LRB- PSA -RRB- Gene Promoter with Serum PSA Level and PSA Changes after Dutasteride Treatment in Korean Men with Benign_Prostatic_Hypertrophy .
25621688	0	Prostate-Specific_Antigen	50,75	PSA	77,80	Prostate-Specific Antigen	PSA	354	354	Gene	Gene	Levels|compound|START_ENTITY Levels|appos|END_ENTITY	The Effect of Testosterone Replacement Therapy on Prostate-Specific_Antigen -LRB- PSA -RRB- Levels in Men Being Treated for Hypogonadism : A Systematic Review and Meta-Analysis .
26862945	0	Prostate-specific_Membrane_Antigen	0,34	PSMA	36,40	Prostate-specific Membrane Antigen	PSMA	2346	2346	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Prostate-specific_Membrane_Antigen -LRB- PSMA -RRB- Expression in the Neovasculature of Gynecologic Malignancies : Implications for PSMA-targeted Therapy .
12746846	0	Prostate-specific_antigen	0,25	PSA	27,30	Prostate-specific antigen	PSA	354	354	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Prostate-specific_antigen -LRB- PSA -RRB- protein does not affect growth of prostate_cancer cells in vitro or prostate_cancer xenografts in vivo .
8647643	0	Prostate-specific_antigen	0,25	prostate-specific_antigen	65,90	Prostate-specific antigen	prostate-specific antigen	354	354	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Prostate-specific_antigen in breast cyst fluid : possible role of prostate-specific_antigen in hormone-dependent breast_cancer .
8847146	0	Prostate-specific_antigen	0,25	urokinase-type_plasminogen_activator	49,85	Prostate-specific antigen	urokinase-type plasminogen activator	354	5328	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Prostate-specific_antigen activates single-chain urokinase-type_plasminogen_activator .
17448023	0	Prostate-specific_membrane_antigen	0,34	PSMA	36,40	Prostate-specific membrane antigen	PSMA	2346	2346	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Prostate-specific_membrane_antigen -LRB- PSMA -RRB- protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate_adenocarcinoma : an immunohistochemical study using mutiple tumour tissue microarray technique .
26500666	0	Prostate_Apoptosis_Response_4	35,64	PAR-4	28,33	Prostate Apoptosis Response 4	PAR-4	5074	5074	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Plant-derived SAC domain of PAR-4 -LRB- Prostate_Apoptosis_Response_4 -RRB- exhibits growth inhibitory effects in prostate_cancer cells .
26945657	0	Prostate_Specific_Antigen	136,161	Vitronectin	108,119	Prostate Specific Antigen	Vitronectin	354	7448	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Evaluation of Vitronectin Expression in Prostate_Cancer and the Clinical Significance of the Association of Vitronectin Expression with Prostate_Specific_Antigen in Detecting Prostate_Cancer .
26945657	0	Prostate_Specific_Antigen	136,161	Vitronectin	14,25	Prostate Specific Antigen	Vitronectin	354	7448	Gene	Gene	Expression|nmod|START_ENTITY Evaluation|nmod|Expression Evaluation|nmod|Expression Expression|compound|END_ENTITY	Evaluation of Vitronectin Expression in Prostate_Cancer and the Clinical Significance of the Association of Vitronectin Expression with Prostate_Specific_Antigen in Detecting Prostate_Cancer .
9150700	0	Prostate_specific_antigen	0,25	GnRH	99,103	Prostate specific antigen	GnRH	354	2796	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Prostate_specific_antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment .
15342669	0	Prostate_stem_cell_antigen	0,26	PSCA	28,32	Prostate stem cell antigen	PSCA	8000	8000	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prostate_stem_cell_antigen -LRB- PSCA -RRB- expression in human prostate_cancer tissues : implications for prostate carcinogenesis and progression_of_prostate_cancer .
6187715	0	Prostatic_Binding_Protein	30,55	PBP	57,60	Prostatic Binding Protein	PBP	29542(Tax:10116)	29542(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Intracellular localization of Prostatic_Binding_Protein -LRB- PBP -RRB- in rat prostate by light and electron microscopic immunocytochemistry .
20667534	0	Protamine_1	0,11	protamine_2	15,26	Protamine 1	protamine 2	5619	5620	Gene	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Protamine_1 to protamine_2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm .
26567242	0	Protease-Activated_Receptor-2	24,53	Cathepsin_S	0,11	Protease-Activated Receptor-2	Cathepsin S	14063(Tax:10090)	13040(Tax:10090)	Gene	Gene	Cleavage|nmod|START_ENTITY Cleavage|compound|END_ENTITY	Cathepsin_S Cleavage of Protease-Activated_Receptor-2 on Endothelial Cells Promotes Microvascular_Diabetes_Complications .
26233549	0	Protease-Activated_Receptor-2	0,29	Transient_Receptor_Potential_Vanilloid_4	43,83	Protease-Activated Receptor-2	Transient Receptor Potential Vanilloid 4	14063(Tax:10090)	63873(Tax:10090)	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Protease-Activated_Receptor-2 Up-Regulates Transient_Receptor_Potential_Vanilloid_4 Function in Mouse Esophageal Keratinocyte .
25944790	0	Protease-Activated_Receptor_2	142,171	Plasmin	120,127	Protease-Activated Receptor 2	Plasmin	2150	5340	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	a-Enolase Causes Proinflammatory Activation of Pulmonary Microvascular Endothelial Cells and Primes Neutrophils Through Plasmin Activation of Protease-Activated_Receptor_2 .
18386288	0	Protease-activated_receptor-1	0,29	fibroblast_growth_factor_7	42,68	Protease-activated receptor-1	fibroblast growth factor 7	2149	2252	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Protease-activated_receptor-1 upregulates fibroblast_growth_factor_7 in stroma of benign_prostatic_hyperplasia .
14632180	0	Protease-activated_receptor-1	0,29	thrombin	31,39	Protease-activated receptor-1	thrombin	2149	2147	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Protease-activated_receptor-1 -LRB- thrombin receptor -RRB- is expressed in mesenchymal portions of human hair follicle .
12874461	0	Protease-activated_receptor-2	0,29	IgA_nephropathy	44,59	Protease-activated receptor-2	IgA nephropathy	2150	60498	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Protease-activated_receptor-2 expression in IgA_nephropathy : a potential role in the pathogenesis of interstitial_fibrosis .
24326025	0	Protease-activated_receptor-2	0,29	NQO-1	40,45	Protease-activated receptor-2	NQO-1	2150	1728	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Protease-activated_receptor-2 activates NQO-1 via Nrf2 stabilization in keratinocytes .
15482468	0	Protease-activated_receptor-2	0,29	PAR-2	31,36	Protease-activated receptor-2	PAR-2	2150	2150	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Protease-activated_receptor-2 -LRB- PAR-2 -RRB- expression in human fibroblasts is regulated by growth factors and extracellular matrix .
20740367	0	Protease-activated_receptor-2	0,29	cyclooxygenase-2	40,56	Protease-activated receptor-2	cyclooxygenase-2	2150	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Protease-activated_receptor-2 regulates cyclooxygenase-2 expression in human bile_duct_cancer via the pathways of mitogen-activated protein kinases and nuclear factor kappa B. BACKGROUND/PURPOSE : Recent studies have suggested that protease-activated_receptor-2 -LRB- PAR-2 -RRB- activity correlates with cell proliferation and tumor growth , and its activation induces expression of cyclooxygenase-2 -LRB- COX-2 -RRB- .
16650817	0	Protease-activated_receptor-2	0,29	vascular_endothelial_growth_factor	40,74	Protease-activated receptor-2	vascular endothelial growth factor	2150	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Protease-activated_receptor-2 regulates vascular_endothelial_growth_factor expression in MDA-MB-231 cells via MAPK pathways .
22941376	0	Protease-activated_receptor-2	0,29	vascular_endothelial_growth_factor	52,86	Protease-activated receptor-2	vascular endothelial growth factor	2150	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Protease-activated_receptor-2 induces expression of vascular_endothelial_growth_factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric_cancer cells .
17376866	0	Protease-activated_receptor-3	0,29	PAR1	47,51	Protease-activated receptor-3	PAR1	2151	2149	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Protease-activated_receptor-3 -LRB- PAR3 -RRB- regulates PAR1 signaling by receptor dimerization .
12479889	0	Protease-activated_receptor_2	0,29	PAR2	31,35	Protease-activated receptor 2	PAR2	2150	2150	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Protease-activated_receptor_2 -LRB- PAR2 -RRB- mediates vascular smooth muscle cell migration induced by tissue factor/factor VIIa complex .
23288842	0	Protease-activated_receptor_2	0,29	PAR2	31,35	Protease-activated receptor 2	PAR2	2150	2150	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Protease-activated_receptor_2 -LRB- PAR2 -RRB- protein and transient_receptor_potential_vanilloid_4 -LRB- TRPV4 -RRB- protein coupling is required for sustained inflammatory signaling .
17591792	0	Protease-activated_receptor_2	0,29	beta-defensin_2	45,60	Protease-activated receptor 2	beta-defensin 2	2150	1673	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Protease-activated_receptor_2 mediates human beta-defensin_2 and CC_chemokine_ligand_20 mRNA expression in response to proteases secreted by Porphyromonas_gingivalis .
10079109	0	Protease-activated_receptors_1_and_4	0,36	thrombin	78,86	Protease-activated receptors 1 and 4	thrombin	2149;9002	2147	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	Protease-activated_receptors_1_and_4 mediate activation of human platelets by thrombin .
16875721	0	Protease_Activated_Receptor_1	15,44	PAR1	46,50	Protease Activated Receptor 1	PAR1	2149	2149	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The pattern of Protease_Activated_Receptor_1 -LRB- PAR1 -RRB- expression in endometrial_carcinoma .
18612544	0	Protease_activated_receptor_1	0,29	PAR-1	31,36	Protease activated receptor 1	PAR-1	2149	2149	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Protease_activated_receptor_1 -LRB- PAR-1 -RRB- activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial_protein_C_receptor is occupied by its natural ligand .
18612544	0	Protease_activated_receptor_1	0,29	thrombin	52,60	Protease activated receptor 1	thrombin	2149	2147	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Protease_activated_receptor_1 -LRB- PAR-1 -RRB- activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial_protein_C_receptor is occupied by its natural ligand .
25734998	0	Protease_activated_receptor_2	0,29	PAR2	31,35	Protease activated receptor 2	PAR2	14063(Tax:10090)	14063(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Protease_activated_receptor_2 -LRB- PAR2 -RRB- activation is sufficient to induce the transition to a chronic_pain state .
8360185	0	Protease_nexin-1	0,16	interleukin-1_and_dexamethasone	56,87	Protease nexin-1	interleukin-1 and dexamethasone	5270	3552	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Protease_nexin-1 , a thrombin inhibitor , is regulated by interleukin-1_and_dexamethasone in normal human fibroblasts .
7704602	0	Protease_nexin-1	0,16	thrombin	27,35	Protease nexin-1	thrombin	5270	2147	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Protease_nexin-1 , a potent thrombin inhibitor , is reduced around cerebral blood vessels in Alzheimer 's _ disease .
8360185	0	Protease_nexin-1	0,16	thrombin	20,28	Protease nexin-1	thrombin	5270	2147	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Protease_nexin-1 , a thrombin inhibitor , is regulated by interleukin-1_and_dexamethasone in normal human fibroblasts .
17379830	0	Protease_nexin-1	0,16	thrombomodulin	32,46	Protease nexin-1	thrombomodulin	5270	7056	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protease_nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect .
25364621	0	Protein-Tyrosine_Phosphatase1B	140,170	PTP1B	172,177	Protein-Tyrosine Phosphatase1B	PTP1B	5770	5770	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	4 - -LRB- -LRB- 1E -RRB- -2 - -LRB- 5 - -LRB- 4-hydroxy-3-methoxystyryl - -RRB- -1 - phenyl-1H-pyrazoyl-3-yl -RRB- _ vinyl -RRB- -2 - methoxy-phenol -RRB- -LRB- CNB-001 -RRB- Does Not Regulate Human Recombinant Protein-Tyrosine_Phosphatase1B -LRB- PTP1B -RRB- Activity in vitro .
23148211	0	Protein-disulfide_isomerase	0,27	redox_factor-1	96,110	Protein-disulfide isomerase	redox factor-1	25506(Tax:10116)	79116(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Protein-disulfide_isomerase regulates the thyroid hormone receptor-mediated gene expression via redox_factor-1 through thiol reduction-oxidation .
15465829	0	Protein-tyrosine_phosphatase_1B	0,31	IRE1	44,48	Protein-tyrosine phosphatase 1B	IRE1	19246(Tax:10090)	26918(Tax:10090)	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	Protein-tyrosine_phosphatase_1B potentiates IRE1 signaling during endoplasmic reticulum stress .
25288805	0	Protein-tyrosine_phosphatase_1B	0,31	brain-derived_neurotrophic_factor	72,105	Protein-tyrosine phosphatase 1B	brain-derived neurotrophic factor	19246(Tax:10090)	12064(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Protein-tyrosine_phosphatase_1B -LRB- PTP1B -RRB- is a novel regulator of central brain-derived_neurotrophic_factor and tropomyosin_receptor_kinase_B -LRB- TrkB -RRB- signaling .
15269244	0	Protein-tyrosine_phosphatase_1B	0,31	insulin_receptor	48,64	Protein-tyrosine phosphatase 1B	insulin receptor	5770	3643	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Protein-tyrosine_phosphatase_1B associates with insulin_receptor and negatively regulates insulin signaling without receptor internalization .
12941932	0	Protein-tyrosine_phosphatase_1B	0,31	sterol_regulatory_element-binding_protein-1	77,120	Protein-tyrosine phosphatase 1B	sterol regulatory element-binding protein-1	24697(Tax:10116)	78968(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Protein-tyrosine_phosphatase_1B as new activator for hepatic lipogenesis via sterol_regulatory_element-binding_protein-1 gene expression .
18093973	0	Protein-tyrosine_phosphatase_epsilon	0,36	Shc	47,50	Protein-tyrosine phosphatase epsilon	Shc	19267(Tax:10090)	20416(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Protein-tyrosine_phosphatase_epsilon regulates Shc signaling in a kinase-specific manner : increasing coherence in tyrosine phosphatase signaling .
25911106	0	Protein_Arginine_Methyltransferase_1	17,53	PRMT1	55,60	Protein Arginine Methyltransferase 1	PRMT1	3276	3276	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Redox Control of Protein_Arginine_Methyltransferase_1 -LRB- PRMT1 -RRB- Activity .
20230872	0	Protein_C_inhibitor	0,19	cathepsin_L	35,46	Protein C inhibitor	cathepsin L	5104	1514	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Protein_C_inhibitor regulates both cathepsin_L activity and cell-mediated tumor cell migration .
25687755	0	Protein_Kinase	0,14	Complement_Receptor_Ig	46,68	Protein Kinase	Complement Receptor Ig	1022	11326	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|nmod|END_ENTITY	Protein_Kinase Ca Regulates the Expression of Complement_Receptor_Ig in Human Monocyte-Derived Macrophages .
11725000	0	Protein_Kinase	0,14	Insulin_Receptor	31,47	Protein Kinase	Insulin Receptor	1022	3643	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Protein_Kinase Activity of the Insulin_Receptor Is Essential for Insulin-Regulated Gene Expression .
20936097	0	Protein_Kinase_B	47,63	Akt	64,67	Protein Kinase B	Akt	2185	207	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Cholesteryl_Glucoside_Stimulates Activation of Protein_Kinase_B / Akt in the Motor Neuron-Derived NSC34 Cell Line .
21592956	0	Protein_Kinase_B	37,53	Akt1	102,106	Protein Kinase B	Akt1	2185	207	Gene	Gene	Akt|appos|START_ENTITY Serine|nsubj|Akt Serine|ccomp|required required|nmod|activity activity|amod|END_ENTITY	mTORC2 protein complex-mediated Akt -LRB- Protein_Kinase_B -RRB- Serine 473 Phosphorylation is not required for Akt1 activity in human platelets -LSB- corrected -RSB- .
19617920	0	Protein_Kinase_C	0,16	Endothelin-Converting_Enzyme-1	56,86	Protein Kinase C	Endothelin-Converting Enzyme-1	112476	1889	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Activity Activity|nmod|END_ENTITY	Protein_Kinase_C Regulates the Cell Surface Activity of Endothelin-Converting_Enzyme-1 .
25000588	0	Protein_Kinase_C	47,63	PKC	67,70	Protein Kinase C	PKC	112476	112476	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Discovery of Selective and Orally Bioavailable Protein_Kinase_C -LRB- PKC -RRB- Inhibitors from a Fragment Hit .
24106489	0	Protein_Kinase_C	0,16	SN1	67,70	Protein Kinase C	SN1	112476	10991	Gene	Gene	Phosphorylates|nsubj|START_ENTITY Phosphorylates|dobj|END_ENTITY	Protein_Kinase_C Phosphorylates the System N Glutamine Transporter SN1 -LRB- Slc38a3 -RRB- and Regulates Its Membrane Trafficking and Degradation .
26338704	0	Protein_Kinase_D1	15,32	Gonadotropin-releasing_Hormone	136,166	Protein Kinase D1	Gonadotropin-releasing Hormone	5587	2796	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Protein_Kinase_D1 in Signal Transduction from the Protein_Kinase_C Pathway to the Tyrosine Kinase Pathway in Response to Gonadotropin-releasing_Hormone .
26065686	0	Protein_Tyrosine_Phosphatase_1B	24,55	Cyclooxygenase_2	85,101	Protein Tyrosine Phosphatase 1B	Cyclooxygenase 2	19246(Tax:10090)	19225(Tax:10090)	Gene	Gene	START_ENTITY|dep|Expression Expression|compound|END_ENTITY	Correction : Deletion of Protein_Tyrosine_Phosphatase_1B -LRB- PTP1B -RRB- Enhances Endothelial Cyclooxygenase_2 Expression and Protects Mice from Type 1 Diabetes-Induced_Endothelial_Dysfunction .
26720454	0	Protein_Tyrosine_Phosphatase_1B	14,45	IGF-I	55,60	Protein Tyrosine Phosphatase 1B	IGF-I	19246(Tax:10090)	16000(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Inhibition of Protein_Tyrosine_Phosphatase_1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced_Gliosis in the Retina .
25643610	0	Protein_Tyrosine_Phosphatase_1B	26,57	PTP1B	59,64	Protein Tyrosine Phosphatase 1B	PTP1B	5770	5770	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Small Molecules as Potent Protein_Tyrosine_Phosphatase_1B -LRB- PTP1B -RRB- Inhibitors Documented in Patents from 2009 to 2013 .
26762411	0	Protein_arginine_methyltransferase_1	0,36	Gli1	52,56	Protein arginine methyltransferase 1	Gli1	3276	2735	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protein_arginine_methyltransferase_1 interacts with Gli1 and regulates its transcriptional activity .
23620769	0	Protein_arginine_methyltransferase_1_and_8	0,42	FUS	57,60	Protein arginine methyltransferase 1 and 8	FUS	3276;56341	2521	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Protein_arginine_methyltransferase_1_and_8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo .
22361822	0	Protein_arginine_methyltransferase_5	0,36	PPARy2	120,126	Protein arginine methyltransferase 5	PPARy2	10419	5468	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Protein_arginine_methyltransferase_5 -LRB- Prmt5 -RRB- promotes gene expression of peroxisome_proliferator-activated_receptor_y2 -LRB- PPARy2 -RRB- and its target genes during adipogenesis .
24189068	0	Protein_arginine_methyltransferase_5	0,36	PRMT5	38,43	Protein arginine methyltransferase 5	PRMT5	27374(Tax:10090)	27374(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- inhibition induces lymphoma cell death through reactivation of the retinoblastoma_tumor suppressor pathway and polycomb repressor complex 2 -LRB- PRC2 -RRB- silencing .
24742914	0	Protein_arginine_methyltransferase_6	0,36	estrogen_receptor_a	92,111	Protein arginine methyltransferase 6	estrogen receptor a	55170	2099	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Protein_arginine_methyltransferase_6 enhances ligand-dependent and - independent activity of estrogen_receptor_a via distinct mechanisms .
25605249	0	Protein_arginine_methyltransferase_7	0,36	MMP9	99,103	Protein arginine methyltransferase 7	MMP9	54496	4318	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	Protein_arginine_methyltransferase_7 promotes breast_cancer cell invasion through the induction of MMP9 expression .
2188973	0	Protein_disulfide-isomerase	0,27	thioredoxin_reductase	47,68	Protein disulfide-isomerase	thioredoxin reductase	20468271	282885(Tax:9913)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Protein_disulfide-isomerase is a substrate for thioredoxin_reductase and has thioredoxin-like activity .
18550154	0	Protein_disulfide_isomerase	0,27	tissue_factor	110,123	Protein disulfide isomerase	tissue factor	281373(Tax:9913)	101909187	Gene	Gene	has|nsubj|START_ENTITY has|nmod|END_ENTITY	Protein_disulfide_isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue_factor .
22584572	0	Protein_inhibitor_of_activated_STAT3	0,36	PIAS3	38,43	Protein inhibitor of activated STAT3	PIAS3	10401	10401	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Protein_inhibitor_of_activated_STAT3 -LRB- PIAS3 -RRB- protein promotes SUMOylation and nuclear sequestration of the intracellular_domain of ErbB4 protein .
518927	0	Protein_kinase	0,14	hnRNP	31,36	Protein kinase	hnRNP	1022	9987	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	Protein_kinase associated with hnRNP from Hela cell nuclei .
22438576	0	Protein_kinase	0,14	occludin	33,41	Protein kinase	occludin	444869(Tax:9913)	512405(Tax:9913)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Protein_kinase cb phosphorylates occludin regulating tight junction trafficking in vascular_endothelial_growth_factor-induced permeability in vivo .
16094730	0	Protein_kinase	0,14	phosphoinositide_3-kinase	27,52	Protein kinase	phosphoinositide 3-kinase	1022	5293	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Protein_kinase activity of phosphoinositide_3-kinase regulates beta-adrenergic receptor endocytosis .
19367327	0	Protein_kinase-X	0,16	Pin-1	32,37	Protein kinase-X	Pin-1	19108(Tax:10090)	23988(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protein_kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development .
10557210	0	Protein_kinase_A	0,16	Hedgehog	29,37	Protein kinase A	Hedgehog	34284(Tax:7227)	42737(Tax:7227)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Protein_kinase_A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus .
15336444	0	Protein_kinase_A	0,16	atrial_natriuretic_peptide	77,103	Protein kinase A	atrial natriuretic peptide	25636(Tax:10116)	24602(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Protein_kinase_A dependent signalling mediates anti-apoptotic effects of the atrial_natriuretic_peptide in ischemic livers .
12589790	0	Protein_kinase_A	0,16	epidermal_growth_factor_receptor	71,103	Protein kinase A	epidermal growth factor receptor	25636(Tax:10116)	24329(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Protein_kinase_A mediates cAMP-induced tyrosine phosphorylation of the epidermal_growth_factor_receptor .
2394752	0	Protein_kinase_A	0,16	phosducin	40,49	Protein kinase A	phosducin	25636(Tax:10116)	287007(Tax:9913)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Protein_kinase_A phosphorylates retinal phosducin on serine 73 in situ .
25065544	0	Protein_kinase_B	0,16	AKT1	18,22	Protein kinase B	AKT1	2185	207	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Protein_kinase_B -LRB- AKT1 -RRB- genotype mediates sensitivity to cannabis-induced impairments in psychomotor control .
15192111	0	Protein_kinase_B	0,16	AKT_1	17,22	Protein kinase B	AKT 1	2185	207	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	Protein_kinase_B / AKT_1 plays a pivotal role in insulin-like_growth_factor-1_receptor signaling induced 3T3-L1 adipocyte differentiation .
10330141	0	Protein_kinase_B	0,16	Akt	17,20	Protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|participates participates|nsubj|END_ENTITY	Protein_kinase_B / Akt participates in GLUT4 translocation by insulin in L6 myoblasts .
12393870	0	Protein_kinase_B	0,16	Akt	17,20	Protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|prevents prevents|nsubj|END_ENTITY	Protein_kinase_B / Akt prevents fatty_acid-induced apoptosis in pancreatic beta-cells -LRB- INS-1 -RRB- .
15047842	0	Protein_kinase_B	0,16	Akt	17,20	Protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Protein_kinase_B / Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent .
16243840	0	Protein_kinase_B	0,16	Akt	17,20	Protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|kinase kinase|nsubj|END_ENTITY	Protein_kinase_B / Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size .
16940564	0	Protein_kinase_B	0,16	Akt	17,20	Protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|END_ENTITY	Protein_kinase_B / Akt modulates nephrotoxicant-induced necrosis in renal cells .
23642408	0	Protein_kinase_B	0,16	Akt	17,20	Protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	Protein_kinase_B / Akt is required for complete Freund 's adjuvant-induced upregulation of Nav1 .7 and Nav1 .8 in primary sensory neurons .
9484781	0	Protein_kinase_B	0,16	Akt	17,20	Protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|activated activated|nsubjpass|END_ENTITY	Protein_kinase_B / Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism .
23200933	0	Protein_kinase_B	0,16	Akt1	17,21	Protein kinase B	Akt1	2185	207	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	Protein_kinase_B / Akt1 inhibits autophagy by down-regulating UVRAG expression .
20693286	0	Protein_kinase_B	0,16	ERK1/2	63,69	Protein kinase B	ERK1/2	2185	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Protein_kinase_B -LRB- AKT -RRB- mediates phospholipase_D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells .
20693286	0	Protein_kinase_B	0,16	phospholipase_D	32,47	Protein kinase B	phospholipase D	2185	2822	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Protein_kinase_B -LRB- AKT -RRB- mediates phospholipase_D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells .
15047604	0	Protein_kinase_B-alpha	0,22	pyruvate_dehydrogenase_kinase-4	38,69	Protein kinase B-alpha	pyruvate dehydrogenase kinase-4	207	5166	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	Protein_kinase_B-alpha inhibits human pyruvate_dehydrogenase_kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors .
12783884	0	Protein_kinase_B_alpha	0,22	Akt1	23,27	Protein kinase B alpha	Akt1	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Protein_kinase_B_alpha / Akt1 regulates placental development and fetal growth .
11087731	0	Protein_kinase_B_beta	0,21	Akt2	22,26	Protein kinase B beta	Akt2	208	208	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	Protein_kinase_B_beta / Akt2 plays a specific role in muscle differentiation .
1860872	0	Protein_kinase_C	0,16	5-HT1A_receptor	74,89	Protein kinase C	5-HT1A receptor	112476	3350	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Protein_kinase_C induces phosphorylation and desensitization of the human 5-HT1A_receptor .
12399460	0	Protein_kinase_C	0,16	ASIC2a	57,63	Protein kinase C	ASIC2a	112476	40	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Protein_kinase_C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1 .
12107059	0	Protein_kinase_C	0,16	E-cadherin	56,66	Protein kinase C	E-cadherin	112476	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Protein_kinase_C regulates endocytosis and recycling of E-cadherin .
14654844	0	Protein_kinase_C	0,16	Raf-1	56,61	Protein kinase C	Raf-1	112476	5894	Gene	Gene	switches|nsubj|START_ENTITY switches|nmod|END_ENTITY	Protein_kinase_C switches the Raf kinase inhibitor from Raf-1 to GRK-2 .
7980467	0	Protein_kinase_C	0,16	S-adenosylmethionine_synthetase	46,77	Protein kinase C	S-adenosylmethionine synthetase	24681(Tax:10116)	25331(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein_kinase_C phosphorylation of rat liver S-adenosylmethionine_synthetase : dissociation and production of an active monomer .
8490103	0	Protein_kinase_C	0,16	TNF-alpha	27,36	Protein kinase C	TNF-alpha	112476	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Protein_kinase_C regulates TNF-alpha production by human monocytes .
17293488	0	Protein_kinase_C	0,16	TRPM4	72,77	Protein kinase C	TRPM4	112476	54795	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Protein_kinase_C regulates vascular myogenic tone through activation of TRPM4 .
8824276	0	Protein_kinase_C	0,16	aryl_hydrocarbon_receptor	64,89	Protein kinase C	aryl hydrocarbon receptor	112476	196	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Protein_kinase_C modulates regulation of the CYP1A1 gene by the aryl_hydrocarbon_receptor .
7836756	0	Protein_kinase_C	0,16	cAMP_response_element-binding_protein	48,85	Protein kinase C	cAMP response element-binding protein	24681(Tax:10116)	81646(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Protein_kinase_C mediates activation of nuclear cAMP_response_element-binding_protein -LRB- CREB -RRB- in B lymphocytes stimulated through surface Ig .
10710511	0	Protein_kinase_C	0,16	insulin	27,34	Protein kinase C	insulin	112476	3630	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|action action|compound|END_ENTITY	Protein_kinase_C modulates insulin action in human skeletal muscle .
7724045	0	Protein_kinase_C	0,16	neurotensin	26,37	Protein kinase C	neurotensin	24681(Tax:10116)	299757(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inhibition inhibition|compound|END_ENTITY	Protein_kinase_C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons .
12407104	0	Protein_kinase_C	0,16	protein_kinase_D	32,48	Protein kinase C	protein kinase D	112476	5587	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Protein_kinase_C phosphorylates protein_kinase_D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain .
15806111	0	Protein_kinase_C-alpha	0,22	TNF	32,35	Protein kinase C-alpha	TNF	24680(Tax:10116)	24835(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Protein_kinase_C-alpha mediates TNF release process in RBL-2H3 mast cells .
19940486	0	Protein_kinase_C-alpha	0,22	VCAM-1	58,64	Protein kinase C-alpha	VCAM-1	5578	7412	Gene	Gene	activation|amod|START_ENTITY induces|nsubj|activation induces|dobj|expression expression|compound|END_ENTITY	Protein_kinase_C-alpha activation induces NF-kB-dependent VCAM-1 expression in cultured human umbilical vein endothelial cells treated with sera from preeclamptic patients .
12676934	0	Protein_kinase_C-associated_kinase	0,34	NFkappaB	48,56	Protein kinase C-associated kinase	NFkappaB	54101	4790	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Protein_kinase_C-associated_kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner .
23204109	0	Protein_kinase_C-b	0,18	insulin	55,62	Protein kinase C-b	insulin	5579	3630	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Protein_kinase_C-b contributes to impaired endothelial insulin signaling in humans with diabetes_mellitus .
17316401	0	Protein_kinase_C-delta	0,22	Ebp1	38,42	Protein kinase C-delta	Ebp1	5580	5036	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Protein_kinase_C-delta phosphorylates Ebp1 and prevents its proteolytic degradation , enhancing cell survival .
11463837	0	Protein_kinase_C-delta	0,22	ICAM-1	50,56	Protein kinase C-delta	ICAM-1	5580	3383	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Protein_kinase_C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38_mitogen-activated_protein_kinase .
20151299	0	Protein_kinase_C-delta	0,22	IL-6	65,69	Protein kinase C-delta	IL-6	18753(Tax:10090)	16193(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|effect effect|nmod|END_ENTITY	Protein_kinase_C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells .
18752579	0	Protein_kinase_C-delta	0,22	von_Willebrand_factor	32,53	Protein kinase C-delta	von Willebrand factor	5580	7450	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Protein_kinase_C-delta mediates von_Willebrand_factor secretion from endothelial cells in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- but not histamine .
9416835	0	Protein_kinase_C-epsilon	0,24	Raf-1	45,50	Protein kinase C-epsilon	Raf-1	18754(Tax:10090)	110157(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Protein_kinase_C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity .
12064598	0	Protein_kinase_C-epsilon	0,24	connexin-43	75,86	Protein kinase C-epsilon	connexin-43	5581	2697	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Protein_kinase_C-epsilon mediates phorbol_ester-induced phosphorylation of connexin-43 .
12205039	0	Protein_kinase_C-epsilon	0,24	cyclooxygenase-2	53,69	Protein kinase C-epsilon	cyclooxygenase-2	5581	5743	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Protein_kinase_C-epsilon mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells .
11112322	0	Protein_kinase_C-related_kinase_2	0,33	eIF4E	89,94	Protein kinase C-related kinase 2	eIF4E	5586	1977	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Protein_kinase_C-related_kinase_2 phosphorylates the protein synthesis initiation factor eIF4E in starfish oocytes .
18521081	0	Protein_kinase_C-theta	0,22	KIT	33,36	Protein kinase C-theta	KIT	5588	3815	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Protein_kinase_C-theta regulates KIT expression and proliferation in gastrointestinal_stromal_tumors .
9516463	0	Protein_kinase_C-theta	0,22	moesin	42,48	Protein kinase C-theta	moesin	5588	4478	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Protein_kinase_C-theta phosphorylation of moesin in the actin-binding sequence .
8523529	0	Protein_kinase_C-zeta	0,21	NF-kappa_B	31,41	Protein kinase C-zeta	NF-kappa B	5590	4790	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Protein_kinase_C-zeta mediates NF-kappa_B activation in human_immunodeficiency_virus-infected monocytes .
9045626	0	Protein_kinase_C-zeta	0,21	angiotensin_II	31,45	Protein kinase C-zeta	angiotensin II	25522(Tax:10116)	24179(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Protein_kinase_C-zeta mediates angiotensin_II activation of ERK1/2 in vascular smooth muscle cells .
12061804	0	Protein_kinase_C-zeta	0,21	insulin-responsive_aminopeptidase	37,70	Protein kinase C-zeta	insulin-responsive aminopeptidase	25522(Tax:10116)	171105(Tax:10116)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Protein_kinase_C-zeta phosphorylates insulin-responsive_aminopeptidase in vitro at Ser-80 and Ser-91 .
11063744	0	Protein_kinase_C-zeta	0,21	insulin_receptor_substrate-1	37,65	Protein kinase C-zeta	insulin receptor substrate-1	18762(Tax:10090)	16367(Tax:10090)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Protein_kinase_C-zeta phosphorylates insulin_receptor_substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin .
8321321	0	Protein_kinase_C_alpha	0,22	RAF-1	33,38	Protein kinase C alpha	RAF-1	18750(Tax:10090)	110157(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Protein_kinase_C_alpha activates RAF-1 by direct phosphorylation .
17644309	0	Protein_kinase_C_delta	0,22	IkappaB-kinase_alpha	33,53	Protein kinase C delta	IkappaB-kinase alpha	5580	1147	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Protein_kinase_C_delta activates IkappaB-kinase_alpha to induce the p53 tumor suppressor in response to oxidative stress .
12826681	0	Protein_kinase_C_delta	0,22	Src	31,34	Protein kinase C delta	Src	170538(Tax:10116)	83805(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Protein_kinase_C_delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha .
17904375	0	Protein_kinase_C_delta	0,22	alphaB-crystallin	48,65	Protein kinase C delta	alphaB-crystallin	170538(Tax:10116)	25420(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Protein_kinase_C_delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes .
11078354	0	Protein_kinase_C_delta	0,22	endothelin-1	95,107	Protein kinase C delta	endothelin-1	5580	1906	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Protein_kinase_C_delta but not PKC_epsilon activity is involved in contractile potentiation by endothelin-1 in the porcine coronary artery .
18055557	0	Protein_kinase_C_delta	0,22	mucin	40,45	Protein kinase C delta	mucin	5580	100508689	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Protein_kinase_C_delta regulates airway mucin secretion via phosphorylation of MARCKS protein .
16118209	0	Protein_kinase_C_delta	0,22	p53	115,118	Protein kinase C delta	p53	5580	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	Protein_kinase_C_delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms .
11860281	0	Protein_kinase_C_delta	0,22	protein_tyrosine_phosphatase_mu	50,81	Protein kinase C delta	protein tyrosine phosphatase mu	5580	5797	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Protein_kinase_C_delta -LRB- PKCdelta -RRB- is required for protein_tyrosine_phosphatase_mu -LRB- PTPmu -RRB- - dependent neurite outgrowth .
23454274	0	Protein_kinase_C_delta	0,22	tissue_transglutaminase	41,64	Protein kinase C delta	tissue transglutaminase	5580	7052	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Protein_kinase_C_delta is a substrate of tissue_transglutaminase and a novel autoantigen in coeliac_disease .
17283176	0	Protein_kinase_C_epsilon	0,24	Stat3	156,161	Protein kinase C epsilon	Stat3	18754(Tax:10090)	20848(Tax:10090)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Protein_kinase_C_epsilon , which sensitizes skin to sun 's UV radiation-induced cutaneous_damage and development of squamous_cell_carcinomas , associates with Stat3 .
17553064	0	Protein_kinase_C_epsilon	0,24	keratin_8	40,49	Protein kinase C epsilon	keratin 8	29340(Tax:10116)	25626(Tax:10116)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Protein_kinase_C_epsilon phosphorylates keratin_8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing_hormone .
11248233	0	Protein_kinase_C_mu	0,19	p42	86,89	Protein kinase C mu	p42	5587	23552	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Protein_kinase_C_mu selectively activates the mitogen-activated protein kinase -LRB- MAPK -RRB- p42 pathway .
19047061	0	Protein_kinase_C_theta	0,22	PDK1	63,67	Protein kinase C theta	PDK1	18761(Tax:10090)	228026(Tax:10090)	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Protein_kinase_C_theta -LRB- PKCtheta -RRB- - dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance .
11274147	0	Protein_kinase_C_theta	0,22	Vav1	39,43	Protein kinase C theta	Vav1	5588	7409	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Protein_kinase_C_theta cooperates with Vav1 to induce JNK activity in T-cells .
15024053	0	Protein_kinase_Cdelta	0,21	NF-kappaB	85,94	Protein kinase Cdelta	NF-kappaB	5580	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Protein_kinase_Cdelta selectively regulates protein_kinase_D-dependent activation of NF-kappaB in oxidative stress signaling .
15280372	0	Protein_kinase_Cdelta	0,21	NF-kappaB	61,70	Protein kinase Cdelta	NF-kappaB	5580	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	Protein_kinase_Cdelta mediates lysophosphatidic_acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells .
17875724	0	Protein_kinase_Cepsilon	0,23	Stat3	93,98	Protein kinase Cepsilon	Stat3	5581	6774	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protein_kinase_Cepsilon interacts with signal_transducers_and_activators_of_transcription_3 -LRB- Stat3 -RRB- , phosphorylates Stat3Ser727 , and regulates its constitutive activation in prostate_cancer .
19794144	0	Protein_kinase_D	0,16	COX-2	52,57	Protein kinase D	COX-2	5587	4513	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Protein_kinase_D mediates synergistic expression of COX-2 induced by TNF - -LCB- alpha -RCB- and bradykinin in human colonic myofibroblasts .
8947045	0	Protein_kinase_D	0,16	PKD	18,21	Protein kinase D	PKD	18760(Tax:10090)	18760(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Protein_kinase_D -LRB- PKD -RRB- activation in intact cells through a protein kinase C-dependent signal transduction pathway .
22228765	0	Protein_kinase_D	0,16	RhoA	27,31	Protein kinase D	RhoA	5587	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Protein_kinase_D regulates RhoA activity via rhotekin phosphorylation .
17442957	0	Protein_kinase_D	0,16	TLR5	34,38	Protein kinase D	TLR5	5587	7100	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Protein_kinase_D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin .
18378685	0	Protein_kinase_D	0,16	cAMP_response_element-binding_protein	47,84	Protein kinase D	cAMP response element-binding protein	18760(Tax:10090)	12912(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	Protein_kinase_D links Gq-coupled receptors to cAMP_response_element-binding_protein -LRB- CREB -RRB- - Ser133 phosphorylation in the heart .
24265314	0	Protein_kinase_D	0,16	claudin-1	108,117	Protein kinase D	claudin-1	5587	9076	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|down-regulation down-regulation|nmod|END_ENTITY	Protein_kinase_D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1 .
25063840	0	Protein_kinase_D	0,16	claudin-1	108,117	Protein kinase D	claudin-1	5587	9076	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|down-regulation down-regulation|nmod|END_ENTITY	Protein_kinase_D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1 .
19567672	0	Protein_kinase_D	0,16	cofilin	75,82	Protein kinase D	cofilin	5587	1072	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|phosphorylation phosphorylation|nmod|phosphatase phosphatase|compound|END_ENTITY	Protein_kinase_D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like .
21832093	0	Protein_kinase_D	0,16	cofilin	27,34	Protein kinase D	cofilin	5587	1072	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Protein_kinase_D regulates cofilin activity through p21-activated_kinase_4 .
16584705	0	Protein_kinase_D	0,16	histone_deacetylase_5	41,62	Protein kinase D	histone deacetylase 5	5587	10014	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Protein_kinase_D directly phosphorylates histone_deacetylase_5 via a random sequential kinetic mechanism .
21832093	0	Protein_kinase_D	0,16	p21-activated_kinase_4	52,74	Protein kinase D	p21-activated kinase 4	5587	10298	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Protein_kinase_D regulates cofilin activity through p21-activated_kinase_4 .
15623513	0	Protein_kinase_D1	0,17	HDAC7	33,38	Protein kinase D1	HDAC7	18760(Tax:10090)	56233(Tax:10090)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Protein_kinase_D1 phosphorylates HDAC7 and induces its nuclear export after T-cell_receptor activation .
21696630	0	Protein_kinase_D1	0,17	PKD1	19,23	Protein kinase D1	PKD1	5587	5587	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Protein_kinase_D1 -LRB- PKD1 -RRB- activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal_degeneration .
24806360	0	Protein_kinase_D1	0,17	PKD1	19,23	Protein kinase D1	PKD1	5587	5587	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Protein_kinase_D1 -LRB- PKD1 -RRB- phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress .
15604256	0	Protein_kinase_D2	0,17	Bcr-Abl	66,73	Protein kinase D2	Bcr-Abl	25865	25	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Protein_kinase_D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl + human myeloid_leukemia cells .
15604256	0	Protein_kinase_D2	0,17	Bcr-Abl	77,84	Protein kinase D2	Bcr-Abl	25865	25	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|Bcr-Abl Bcr-Abl|nmod|cells cells|compound|END_ENTITY	Protein_kinase_D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl + human myeloid_leukemia cells .
25218347	0	Protein_kinase_D2	0,17	Golgi_phosphoprotein_3	75,97	Protein kinase D2	Golgi phosphoprotein 3	25865	64083	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Protein_kinase_D2 promotes the proliferation of glioma cells by regulating Golgi_phosphoprotein_3 .
18262756	0	Protein_kinase_D2	0,17	chromogranin_A	28,42	Protein kinase D2	chromogranin A	25865	1113	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Protein_kinase_D2 regulates chromogranin_A secretion in human BON_neuroendocrine_tumour cells .
20631127	0	Protein_kinase_R	0,16	eIF2alpha	59,68	Protein kinase R	eIF2alpha	19106(Tax:10090)	19106(Tax:10090)	Gene	Gene	responsible|nsubj|START_ENTITY responsible|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Protein_kinase_R is responsible for the phosphorylation of eIF2alpha in rotavirus_infection .
24737441	0	Protein_kinase_cAMP-dependent_regulatory_type_II_beta	0,53	PRKAR2B	55,62	Protein kinase cAMP-dependent regulatory type II beta	PRKAR2B	5577	5577	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Protein_kinase_cAMP-dependent_regulatory_type_II_beta -LRB- PRKAR2B -RRB- gene variants in antipsychotic-induced weight_gain .
18347064	0	Protein_phosphatase_4_catalytic_subunit	0,39	Cdk1	50,54	Protein phosphatase 4 catalytic subunit	Cdk1	5531	983	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Protein_phosphatase_4_catalytic_subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation .
23556002	0	Protein_phosphatase_magnesium-dependent_1	0,41	PPM1D	45,50	Protein phosphatase magnesium-dependent 1	PPM1D	8493	8493	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Protein_phosphatase_magnesium-dependent_1 -LRB- PPM1D -RRB- mRNA expression is a prognosis marker for hepatocellular_carcinoma .
26377365	0	Protein_phosphatase_methylesterase-1	0,36	PME-1	38,43	Protein phosphatase methylesterase-1	PME-1	51400	51400	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Protein_phosphatase_methylesterase-1 -LRB- PME-1 -RRB- expression predicts a favorable clinical outcome in colorectal_cancer .
22583656	0	Protein_tyrosine_phosphatase	0,28	PTP	30,33	Protein tyrosine phosphatase	PTP	26191	26191	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Protein_tyrosine_phosphatase -LRB- PTP -RRB- inhibition enhances chromosomal stability after genotoxic stress : decreased chromosomal_instability -LRB- CIN -RRB- at the expense of enhanced genomic_instability -LRB- GIN -RRB- ?
25289035	0	Protein_tyrosine_phosphatase	0,28	PTPN22	29,35	Protein tyrosine phosphatase	PTPN22	26191	26191	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Protein_tyrosine_phosphatase PTPN22 +1858 C/T polymorphism is associated with active vitiligo .
18925540	0	Protein_tyrosine_phosphatase	0,28	insulin_receptor	77,93	Protein tyrosine phosphatase	insulin receptor	26191	3643	Gene	Gene	START_ENTITY|nmod|fibroblasts fibroblasts|nmod|patients patients|nmod|mutation mutation|compound|END_ENTITY	Protein_tyrosine_phosphatase regulation in fibroblasts from patients with an insulin_receptor gene mutation .
22106411	0	Protein_tyrosine_phosphatase-like_A	0,35	MyoG	97,101	Protein tyrosine phosphatase-like A	MyoG	9200	4656	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Protein_tyrosine_phosphatase-like_A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway .
16477024	0	Protein_tyrosine_phosphatase_1B	0,31	CSF-1	84,89	Protein tyrosine phosphatase 1B	CSF-1	5770	1435	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signaling signaling|compound|END_ENTITY	Protein_tyrosine_phosphatase_1B negatively regulates macrophage development through CSF-1 signaling .
16949833	0	Protein_tyrosine_phosphatase_1B	0,31	Smad2	61,66	Protein tyrosine phosphatase 1B	Smad2	5770	4087	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Protein_tyrosine_phosphatase_1B regulates TGF_beta_1-induced Smad2 activation through PI3 kinase-dependent pathway .
8826975	0	Protein_tyrosine_phosphatase_1B	0,31	insulin_receptor	61,77	Protein tyrosine phosphatase 1B	insulin receptor	5770	3643	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protein_tyrosine_phosphatase_1B interacts with the activated insulin_receptor .
23640882	0	Protein_tyrosine_phosphatase_1B	0,31	pyruvate_kinase_M2	42,60	Protein tyrosine phosphatase 1B	pyruvate kinase M2	5770	5315	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Protein_tyrosine_phosphatase_1B regulates pyruvate_kinase_M2 tyrosine phosphorylation .
22801373	0	Protein_tyrosine_phosphatase_a	0,30	BCAR3	56,61	Protein tyrosine phosphatase a	BCAR3	5786	8412	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	Protein_tyrosine_phosphatase_a phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions .
16339530	0	Protein_tyrosine_phosphatase_alpha	0,34	Fyn	45,48	Protein tyrosine phosphatase alpha	Fyn	19262(Tax:10090)	14360(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Protein_tyrosine_phosphatase_alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts .
10562275	0	Protein_tyrosine_phosphatase_alpha	0,34	fyn	143,146	Protein tyrosine phosphatase alpha	fyn	5786	2534	Gene	Gene	form|nsubj|START_ENTITY form|dobj|complex complex|acl|linked linked|nmod|END_ENTITY	Protein_tyrosine_phosphatase_alpha -LRB- PTPalpha -RRB- and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn .
18854601	0	Protein_tyrosine_phosphatase_interacting_protein_51	0,51	PTPIP51	53,60	Protein tyrosine phosphatase interacting protein 51	PTPIP51	55177	55177	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Protein_tyrosine_phosphatase_interacting_protein_51 -LRB- PTPIP51 -RRB- mRNA expression and localization and its in vitro interacting partner protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- in human placenta of the first , second , and third trimester .
16893384	0	Protein_tyrosine_phosphatase_non-receptor_type_22	0,49	PTPN22	51,57	Protein tyrosine phosphatase non-receptor type 22	PTPN22	26191	26191	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Protein_tyrosine_phosphatase_non-receptor_type_22 -LRB- PTPN22 -RRB- gene R620W variant and sporadic_idiopathic_hypoparathyroidism in Asian Indians .
9139722	0	Proteinase	0,10	plasminogen_activator_inhibitor_1	68,101	Proteinase	plasminogen activator inhibitor 1	100616101	5054	Gene	Gene	START_ENTITY|nmod|mutants mutants|nmod|END_ENTITY	Proteinase specificity and functional diversity in point mutants of plasminogen_activator_inhibitor_1 .
17962194	0	Proteinase-activated_receptor-2	0,31	cyclooxygenase-2	40,56	Proteinase-activated receptor-2	cyclooxygenase-2	2150	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Proteinase-activated_receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic_AMP-response element-binding protein .
19889854	0	Proteinase-activated_receptor-4	0,31	PAR4	33,37	Proteinase-activated receptor-4	PAR4	116498(Tax:10116)	116498(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Proteinase-activated_receptor-4 -LRB- PAR4 -RRB- activation leads to sensitization of rat joint primary afferents via a bradykinin_B2 receptor-dependent mechanism .
8738804	0	Proteinase_3	0,12	IL-8	74,78	Proteinase 3	IL-8	5657	3576	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Proteinase_3 , the major autoantigen of Wegener 's _ granulomatosis , enhances IL-8 production by endothelial cells in vitro .
11316851	0	Proteinase_3	0,12	monocyte_chemoattractant_protein-1	34,68	Proteinase 3	monocyte chemoattractant protein-1	5657	6347	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Proteinase_3 enhances endothelial monocyte_chemoattractant_protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1 .
9851866	0	Proteinase_inhibitor_6	0,22	PI-6	24,28	Proteinase inhibitor 6	PI-6	5269	5269	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Proteinase_inhibitor_6 -LRB- PI-6 -RRB- expression in human skin : induction of PI-6 and a PI-6 / proteinase complex during keratinocyte differentiation .
11326545	0	Proteinkinase_B	1,16	Akt	17,20	Proteinkinase B	Akt	2185	207	Gene	Gene	START_ENTITY|dep|-RSB- -RSB-|compound|END_ENTITY	-LSB- Proteinkinase_B / Akt -RSB- .
1730648	0	Proteoglycan-Lb	0,15	osteoinductive_factor	133,154	Proteoglycan-Lb	osteoinductive factor	417890(Tax:9031)	4969	Gene	Gene	related|nsubjpass|START_ENTITY related|xcomp|END_ENTITY	Proteoglycan-Lb , a small dermatan sulfate proteoglycan expressed in embryonic chick_epiphyseal_cartilage , is structurally related to osteoinductive_factor .
26645987	0	Prothrombin	45,56	MASP-1	71,77	Prothrombin	MASP-1	2147	5648	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	MASP-1 Induced Clotting - The First Model of Prothrombin Activation by MASP-1 .
12627661	0	Prothrombin	0,11	antithrombin	30,42	Prothrombin	antithrombin	2147	462	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Prothrombin G20210A mutation , antithrombin , heparin cofactor II , protein_C , and protein S defects .
10627484	0	Prothrombin	0,11	factor_Xa	63,72	Prothrombin	factor Xa	2147	2159	Gene	Gene	Antonio|compound|START_ENTITY Antonio|dep|substitution substitution|nmod|results results|amod|END_ENTITY	Prothrombin San Antonio : a single amino_acid substitution at a factor_Xa activation site -LRB- Arg320_to_His -RRB- results in dysprothrombinemia .
11290592	0	Prothrombin	0,11	factor_Xa	21,30	Prothrombin	factor Xa	2147	2159	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Prothrombin protects factor_Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex .
3787558	0	Prothrombin	0,11	factor_Xa	80,89	Prothrombin	factor Xa	2147	2159	Gene	Gene	Clamart|compound|START_ENTITY Clamart|dep|variant variant|nmod|END_ENTITY	Prothrombin Clamart : prothrombin variant with defective Arg 320-IIe cleavage by factor_Xa .
6580622	0	Prothrombin	0,11	factor_Xa	58,67	Prothrombin	factor Xa	2147	2159	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Prothrombin is activated on vascular endothelial cells by factor_Xa and calcium .
7836355	0	Prothrombin	0,11	prothrombinase	26,40	Prothrombin	prothrombinase	2147	2159	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Prothrombin activation by prothrombinase in a tubular flow reactor .
9167017	0	Prothrombin	0,11	prothrombinase	48,62	Prothrombin	prothrombinase	2147	2159	Gene	Gene	conversion|compound|START_ENTITY conversion|nmod|conditions conditions|nmod|END_ENTITY	Prothrombin conversion under flow conditions by prothrombinase assembled on adherent platelets .
10938099	0	Prothymosin_alpha	0,17	estrogen_receptor	39,56	Prothymosin alpha	estrogen receptor	100506248	2099	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Prothymosin_alpha selectively enhances estrogen_receptor transcriptional activity by interacting with a repressor_of_estrogen_receptor_activity .
1814846	0	Prothymosin_alpha	0,17	interleukin_2_receptor	27,49	Prothymosin alpha	interleukin 2 receptor	100506248	3559	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Prothymosin_alpha enhances interleukin_2_receptor expression in normal human T-lymphocytes .
24371087	0	Protocadherin-18b	0,17	Nap1	33,37	Protocadherin-18b	Nap1	562031(Tax:7955)	561894(Tax:7955)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish .
21413931	0	Protor-1	0,8	SGK1	65,69	Protor-1	SGK1	109270(Tax:10090)	20393(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney .
21964062	0	Protor-2	0,8	tristetraprolin	24,39	Protor-2	tristetraprolin	79899	7538	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress .
12816048	0	Prox-1	46,52	Ptx-2	54,59	Prox-1	Ptx-2	19130(Tax:10090)	18741(Tax:10090)	Gene	Gene	Expression|amod|START_ENTITY Expression|acl|END_ENTITY	-LSB- Expression of regulatory genes Oct-4 , Pax-6 , Prox-1 , Ptx-2 at the initial stages of differentiation of embryonic stem cells in vitro -RSB- .
18652815	0	Prox1	0,5	Atoh1	21,26	Prox1	Atoh1	19130(Tax:10090)	11921(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Prox1 interacts with Atoh1 and Gfi1 , and regulates cellular differentiation in the inner_ear_sensory_epithelia .
23395615	0	Prox1	34,39	HIF-1a	48,54	Prox1	HIF-1a	5629	3091	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the Prox1 gene by HIF-1a and HIF-2a in response to hypoxia .
23626788	0	Prox1	0,5	LSD1	30,34	Prox1	LSD1	5629	23028	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription .
19023449	0	Prox1	20,25	PCNA	0,4	Prox1	PCNA	395802(Tax:9031)	373984(Tax:9031)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PCNA interacts with Prox1 and represses its transcriptional activity .
21436036	0	Prox1	34,39	Prospero-related_homeobox_1	0,27	Prox1	Prospero-related homeobox 1	5629	5629	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prospero-related_homeobox_1 gene -LRB- Prox1 -RRB- is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis .
25411508	0	Prox1	0,5	olig2	16,21	Prox1	olig2	19130(Tax:10090)	50913(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Prox1 regulates olig2 expression to modulate binary fate decisions in spinal cord neurons .
24944097	0	Prox1	55,60	podoplanin	30,40	Prox1	podoplanin	19130(Tax:10090)	14726(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of podoplanin expression by Prox1 in lymphatic endothelial cells .
2613230	0	Prp	0,3	proline-rich_protein	5,25	Prp	proline-rich protein	19131(Tax:10090)	19131(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Prp -LRB- proline-rich_protein -RRB- genes linked to markers Es-12 -LRB- esterase-12 -RRB- , Ea-10 -LRB- erythrocyte alloantigen -RRB- , and loci on distal mouse chromosome 6 .
17118936	0	Prp19p	24,30	lipid_droplet-associated_protein	36,68	Prp19p	lipid droplet-associated protein	28000(Tax:10090)	103968(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of mouse Prp19p as a lipid_droplet-associated_protein and its possible involvement in the biogenesis of lipid droplets .
19014439	0	Prp40	41,46	Luc7	73,77	Prp40	Luc7	853857(Tax:4932)	851471(Tax:4932)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	The FF domains of yeast U1 snRNP protein Prp40 mediate interactions with Luc7 and Snu71 .
21061267	0	Prr15	40,45	proline_rich_15	23,38	Prr15	proline rich 15	78004(Tax:10090)	78004(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis of proline_rich_15 -LRB- Prr15 -RRB- in mouse and human gastrointestinal_tumors .
18689483	0	PrrA	61,65	hemA	48,52	PrrA	hemA	3718682(Tax:272943)	3720398(Tax:272943)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the Rhodobacter_sphaeroides_2 .4.1 hemA gene by PrrA and FnrL .
26913565	0	Prrxl1	99,105	Casz1	33,38	Prrxl1	Casz1	107751(Tax:10090)	69743(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late born excitatory interneurons .
12741393	0	Prx1	26,30	FAK	0,3	Prx1	FAK	18933(Tax:10090)	14083(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration .
20647304	0	Prx1	162,166	T-LAK_cell-originated_protein_kinase	0,36	Prx1	T-LAK cell-originated protein kinase	5052	55872	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity prevents|nmod|regulation prevents|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
20647304	0	Prx1	63,67	T-LAK_cell-originated_protein_kinase	0,36	Prx1	T-LAK cell-originated protein kinase	5052	55872	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
20647304	0	Prx1	63,67	TOPK	38,42	Prx1	TOPK	5052	55872	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
17050172	0	Prx_II	39,45	peroxiredoxin_II	21,37	Prx II	peroxiredoxin II	21672(Tax:10090)	21672(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of peroxiredoxin_II -LRB- Prx_II -RRB- on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast -LRB- MEF -RRB- senescence .
26533827	0	Ps1	63,66	Presenilin_1	49,61	Ps1	Presenilin 1	5663	5663	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	A Study On Cytogenetic And Molecular Analysis Of Presenilin_1 -LRB- Ps1 -RRB- Gene In Alzheimer 's _ Disease .
16520334	0	Psd95	14,19	Mpp4	0,4	Psd95	Mpp4	13385(Tax:10090)	227157(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse .
16175500	0	Pseudoautosomal_region_1	17,41	SHOX	66,70	Pseudoautosomal region 1	SHOX	145624	6473	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	A novel class of Pseudoautosomal_region_1 deletions downstream of SHOX is associated with Leri-Weill_dyschondrosteosis .
15647114	0	Psg	70,73	pregnancy-specific_glycoprotein	37,68	Psg	pregnancy-specific glycoprotein	26436(Tax:10090)	26436(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and evolution of the mouse pregnancy-specific_glycoprotein -LRB- Psg -RRB- gene locus .
9367687	0	Psmb10	101,107	proteasome_subunit_lmp10	75,99	Psmb10	proteasome subunit lmp10	19171(Tax:10090)	19171(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	DNA sequence , chromosomal localization , and tissue expression of the mouse proteasome_subunit_lmp10 -LRB- Psmb10 -RRB- gene .
12960389	0	Pso4	14,18	terminal_deoxynucleotidyl_transferase	64,101	Pso4	terminal deoxynucleotidyl transferase	27339	1791	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of human Pso4 in mammalian DNA repair and association with terminal_deoxynucleotidyl_transferase .
14688088	0	PspA	11,15	PspA	34,38	PspA	PspA	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface .
14688088	0	PspA	34,38	PspA	11,15	PspA	PspA	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of PspA and antibodies to PspA on activation and deposition of complement on the pneumococcal surface .
11292770	0	PspC	0,4	factor_H	50,58	PspC	factor H	6440	3075	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	PspC , a pneumococcal surface protein , binds human factor_H .
12228288	0	PspC	75,79	factor_H	31,39	PspC	factor H	6440	3075	Gene	Gene	repeats|nsubj|START_ENTITY binds|ccomp|repeats binds|nsubj|END_ENTITY	The human complement regulator factor_H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15 .
15232165	0	PspC	35,39	factor_H	21,29	PspC	factor H	6440	3075	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human factor_H with PspC of Streptococcus_pneumoniae .
8081943	0	Pst	2,5	HEXA	27,31	Pst	HEXA	7903	3073	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	A Pst + polymorphism in the HEXA gene with an unusual geographic distribution .
7951555	0	Pst	43,46	insulin	74,81	Pst	insulin	7903	3630	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Hind III site causing Proinsulin Kyoto and Pst I site polymorphism of the insulin gene in Japanese : its lack of association with either IDDM or NIDDM .
25227845	0	PstI	46,50	CYP2E1	39,45	PstI	CYP2E1	6690	1571	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Significant genotype difference in the CYP2E1 PstI polymorphism of Indigenous groups in Sabah , Malaysia with Asian and non-Asian populations .
26125714	0	PstI	7,11	CYP2E1	0,6	PstI	CYP2E1	6690	1571	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	CYP2E1 PstI polymorphism increases cervical_neoplasia risk : a meta-analysis .
1977142	0	PstI	49,53	PF4	80,83	PstI	PF4	6690	5196	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Polymerase chain reaction -LRB- PCR -RRB- for detection of PstI polymorphism in the human PF4 gene .
24277933	0	Psy2	0,4	Mth1	64,68	Psy2	Mth1	57223	4521	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression .
24277933	0	Psy2	0,4	Pph3	40,44	Psy2	Pph3	57223	5531	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Psy2 targets the PP4 family phosphatase Pph3 to dephosphorylate Mth1 and repress glucose transporter gene expression .
18660545	0	Ptc1	23,27	PARP-1	0,6	Ptc1	PARP-1	19206(Tax:10090)	11545(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	PARP-1 cooperates with Ptc1 to suppress medulloblastoma_and_basal_cell_carcinoma .
12839638	0	Ptc1	20,24	Shh	15,18	Ptc1	Shh	19206(Tax:10090)	20423(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of Shh , Ptc1 , Ptc2 mRNA in the cap stage of mouse molar -RSB- .
15380514	0	Ptc1	94,98	Shh	19,22	Ptc1	Shh	19206(Tax:10090)	20423(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY medulloblastoma|nmod|mice eliminates|dobj|medulloblastoma eliminates|nsubj|Suppression Suppression|nmod|pathway pathway|compound|END_ENTITY	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 -LRB- + / - -RRB- p53 -LRB- - / - -RRB- mice .
15380514	0	Ptc1	94,98	p53	103,106	Ptc1	p53	19206(Tax:10090)	22060(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 -LRB- + / - -RRB- p53 -LRB- - / - -RRB- mice .
22759636	0	Pten	104,108	Akt	82,85	Pten	Akt	43991(Tax:7227)	41957(Tax:7227)	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam .
25531328	0	Pten	74,78	Akt	22,25	Pten	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	model|compound|START_ENTITY activation|nmod|model activation|compound|END_ENTITY	Loss of ATF3 promotes Akt activation and prostate_cancer development in a Pten knockout mouse model .
26023714	0	Pten	37,41	Akt	69,72	Pten	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	Specific|compound|START_ENTITY Steatosis|nmod|Specific KO|nsubj|Steatosis KO|dobj|Mice Mice|nmod|Inactivation Inactivation|compound|END_ENTITY	1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation .
26023714	0	Pten	37,41	Akt	69,72	Pten	Akt	19211(Tax:10090)	11651(Tax:10090)	Gene	Gene	Specific|compound|START_ENTITY Steatosis|nmod|Specific KO|nsubj|Steatosis KO|dobj|Mice Mice|nmod|Inactivation Inactivation|compound|END_ENTITY	1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation .
21743498	0	Pten	49,53	Akt2	11,15	Pten	Akt2	19211(Tax:10090)	11652(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	The effect Akt2 deletion on tumor development in Pten -LRB- + / - -RRB- mice .
26196517	0	Pten	59,63	Androgen_Receptor	18,35	Pten	Androgen Receptor	19211(Tax:10090)	11835(Tax:10090)	Gene	Gene	Model|compound|START_ENTITY Identification|nmod|Model Identification|nmod|Variants Variants|compound|END_ENTITY	Identification of Androgen_Receptor Splice Variants in the Pten Deficient Murine Prostate_Cancer Model .
26196517	0	Pten	59,63	Androgen_Receptor	18,35	Pten	Androgen Receptor	19211(Tax:10090)	11835(Tax:10090)	Gene	Gene	Model|compound|START_ENTITY Identification|nmod|Model Identification|nmod|Variants Variants|compound|END_ENTITY	Identification of Androgen_Receptor Splice Variants in the Pten Deficient Murine Prostate_Cancer Model .
26998759	0	Pten	71,75	Androgen_Receptor	30,47	Pten	Androgen Receptor	19211(Tax:10090)	11835(Tax:10090)	Gene	Gene	Model|compound|START_ENTITY Variants|nmod|Model Variants|compound|END_ENTITY	Correction : Identification of Androgen_Receptor Splice Variants in the Pten Deficient Murine Prostate_Cancer Model .
22513362	0	Pten	0,4	Aurora-A	15,23	Pten	Aurora-A	19211(Tax:10090)	20878(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development .
22763434	0	Pten	36,40	Cbl-b	20,25	Pten	Cbl-b	19211(Tax:10090)	208650(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	E3_ubiquitin_ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity .
23319880	0	Pten	28,32	EGFR	38,42	Pten	EGFR	5728	1956	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|Overexpression Overexpression|compound|END_ENTITY	Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST .
22513362	0	Pten	0,4	Fbxw7	44,49	Pten	Fbxw7	19211(Tax:10090)	50754(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development .
15467756	0	Pten	67,71	NF-kappaB	117,126	Pten	NF-kappaB	5728	4790	Gene	Gene	expression|amod|START_ENTITY due|nmod|expression factors|amod|due factors|amod|END_ENTITY	The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic_cancer cells .
25132272	0	Pten	69,73	TGF-b	0,5	Pten	TGF-b	19211(Tax:10090)	21803(Tax:10090)	Gene	Gene	inactivation|compound|START_ENTITY induced|nmod|inactivation tumorigenesis|acl|induced pattern|nmod|tumorigenesis alters|dobj|pattern alters|nsubj|signaling signaling|compound|END_ENTITY	TGF-b signaling alters the pattern of liver tumorigenesis induced by Pten inactivation .
19150964	0	Pten	0,4	c-Myc	25,30	Pten	c-Myc	5728	4609	Gene	Gene	converge|nsubj|START_ENTITY converge|advcl|END_ENTITY	Pten and p53 converge on c-Myc to control differentiation , self-renewal , and transformation of normal and neoplastic stem cells in glioblastoma .
11504907	0	Pten	80,84	mTOR	16,20	Pten	mTOR	19211(Tax:10090)	21977(Tax:10090)	Gene	Gene	/|compound|START_ENTITY activity|nmod|/ reduces|dobj|activity reduces|nsubj|inhibitor inhibitor|nmod|END_ENTITY	An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten + / - mice .
17346540	0	Pten	80,84	mTOR	57,61	Pten	mTOR	19211(Tax:10090)	21977(Tax:10090)	Gene	Gene	model|compound|START_ENTITY inhibition|nmod|model inhibition|compound|END_ENTITY	Reduced progression of endometrial_hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model .
19185849	0	Pten	77,81	mTOR	0,4	Pten	mTOR	19211(Tax:10090)	21977(Tax:10090)	Gene	Gene	loss|amod|START_ENTITY induced|nmod|loss prostate_cancer|acl|induced development|nmod|prostate_cancer required|nmod|development required|nsubjpass|END_ENTITY	mTOR complex 2 is required for the development of prostate_cancer induced by Pten loss in mice .
21040901	0	Pten	113,117	mTOR	0,4	Pten	mTOR	5728	21977(Tax:10090)	Gene	Gene	deletion|compound|START_ENTITY cells|nmod|deletion inhibit|dobj|cells suppressors|acl:relcl|inhibit induces|dobj|suppressors induces|nsubj|activation activation|compound|END_ENTITY	mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion .
24322983	0	Pten	82,86	mTOR	120,124	Pten	mTOR	19211(Tax:10090)	21977(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY driven|nmod|loss endometrial_cancer|acl|driven model|nmod|endometrial_cancer responsive|nsubj|model responsive|nmod|inhibition inhibition|compound|END_ENTITY	A genetic mouse model of invasive endometrial_cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition .
27050906	0	Pten	135,139	mTOR	0,4	Pten	mTOR	5728	21977(Tax:10090)	Gene	Gene	inactivation|compound|START_ENTITY cells|nmod|inactivation contribute|nmod|cells expression|acl|contribute regulates|dobj|expression regulates|nsubj|END_ENTITY	mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation .
19281769	0	Pten	35,39	tumor_suppressor	50,66	Pten	tumor suppressor	19211(Tax:10090)	7248	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Simultaneous haploinsufficiency of Pten and Trp53 tumor_suppressor genes accelerates tumorigenesis in a mouse model of prostate_cancer .
22265691	0	Ptf1a	68,73	MiR-18a	0,7	Ptf1a	MiR-18a	256297	406953	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells .
22372950	0	Ptf1a	58,63	Rbms3	0,5	Ptf1a	Rbms3	19213(Tax:10090)	207181(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Rbms3 , an RNA-binding protein , mediates the expression of Ptf1a by binding to its 3 ` UTR during mouse pancreas development .
20018844	0	Ptgs2	67,72	prostaglandin-endoperoxide_synthase_2	28,65	Ptgs2	prostaglandin-endoperoxide synthase 2	5743	5743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Growth factor regulation of prostaglandin-endoperoxide_synthase_2 -LRB- Ptgs2 -RRB- expression in colonic mesenchymal stem cells .
1354597	0	Pthlh	61,66	parathyroid_hormone-like_peptide	22,54	Pthlh	parathyroid hormone-like peptide	19227(Tax:10090)	19227(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of mouse parathyroid_hormone-like_peptide gene -LRB- Pthlh -RRB- to distal chromosome 6 using interspecific backcross mice and in situ hybridization .
21276203	0	Pto-interacting_1-4	31,50	oxidative_signal-inducible_1	77,105	Pto-interacting 1-4	oxidative signal-inducible 1	819320(Tax:3702)	822119(Tax:3702)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The Arabidopsis protein kinase Pto-interacting_1-4 is a common target of the oxidative_signal-inducible_1 and mitogen-activated protein kinases .
7559654	0	Ptp1	109,113	Fpr3	23,27	Ptp1	Fpr3	851368(Tax:4932)	854901(Tax:4932)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1 .
26898802	0	Ptpmt1	0,6	HIF-2a	18,24	Ptpmt1	HIF-2a	114971	2034	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Ptpmt1 induced by HIF-2a regulates the proliferation and glucose metabolism in erythroleukemia cells .
8790445	0	Ptpra	88,93	LRP	78,81	Ptpra	LRP	19262(Tax:10090)	16971(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regional localization of rat and mouse protein-tyrosine phosphatase PTP_alpha / LRP gene -LRB- Ptpra -RRB- by fluorescence in situ hybridization .
8790445	0	Ptpra	88,93	PTP_alpha	68,77	Ptpra	PTP alpha	19262(Tax:10090)	19262(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regional localization of rat and mouse protein-tyrosine phosphatase PTP_alpha / LRP gene -LRB- Ptpra -RRB- by fluorescence in situ hybridization .
17909891	0	Ptprk	63,68	protein_tyrosine_phosphatase_kappa	27,61	Ptprk	protein tyrosine phosphatase kappa	360302(Tax:10116)	360302(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A deletion mutation of the protein_tyrosine_phosphatase_kappa -LRB- Ptprk -RRB- gene is responsible for T-helper immunodeficiency -LRB- thid -RRB- in the LEC rat .
25519047	0	Ptprz1	74,80	midkine	48,55	Ptprz1	midkine	25613(Tax:10116)	81517(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the heparin-binding growth factor midkine and its receptor , Ptprz1 , in adult rat pituitary .
25227666	0	Pttg1	0,5	TGFb	15,19	Pttg1	TGFb	9232	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Pttg1 inhibits TGFb signaling in breast_cancer cells to promote their growth .
12816048	0	Ptx-2	54,59	Prox-1	46,52	Ptx-2	Prox-1	18741(Tax:10090)	19130(Tax:10090)	Gene	Gene	Expression|acl|START_ENTITY Expression|amod|END_ENTITY	-LSB- Expression of regulatory genes Oct-4 , Pax-6 , Prox-1 , Ptx-2 at the initial stages of differentiation of embryonic stem cells in vitro -RSB- .
11048804	0	Ptx1	37,41	pituitary_homeo_box_1	14,35	Ptx1	pituitary homeo box 1	5307	5307	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of pituitary_homeo_box_1 -LRB- Ptx1 -RRB- in human non-neoplastic pituitaries and pituitary_adenomas .
10800925	0	Ptx3	60,64	tyrosine_hydroxylase	72,92	Ptx3	tyrosine hydroxylase	19288(Tax:10090)	21823(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	A response element for the homeodomain transcription factor Ptx3 in the tyrosine_hydroxylase gene promoter .
25631823	0	Puf4p	33,38	YHB1	65,69	Puf4p	YHB1	852870(Tax:4932)	853149(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Conditional regulation of Puf1p , Puf4p and Puf5p activity alters YHB1 mRNA stability for a rapid response to toxic nitric_oxide stress in yeast .
12667987	0	Pum1	6,10	Pumilio	42,49	Pum1	Pumilio	9698	41094(Tax:7227)	Gene	Gene	START_ENTITY|appos|members members|nmod|family family|compound|END_ENTITY	Mouse Pum1 and Pum2 genes , members of the Pumilio family of RNA-binding proteins , show differential expression in fetal and adult hematopoietic stem cells and progenitors .
10559987	0	Pumilio	9,16	Nanos	36,41	Pumilio	Nanos	41094(Tax:7227)	42297(Tax:7227)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos .
12667987	0	Pumilio	42,49	Pum1	6,10	Pumilio	Pum1	41094(Tax:7227)	9698	Gene	Gene	family|compound|START_ENTITY members|nmod|family END_ENTITY|appos|members	Mouse Pum1 and Pum2 genes , members of the Pumilio family of RNA-binding proteins , show differential expression in fetal and adult hematopoietic stem cells and progenitors .
12511597	0	Pumilio-2	6,15	DAZ	87,90	Pumilio-2	DAZ	23369	1617	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ -LRB- Deleted in AZoospermia -RRB- and DAZ-like proteins .
16741925	0	Pur-alpha	18,27	E2F-1	40,45	Pur-alpha	E2F-1	5813	1869	Gene	Gene	promoter|amod|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the Pur-alpha promoter by E2F-1 .
22553010	0	Pur-alpha	0,9	RhoA	20,24	Pur-alpha	RhoA	19290(Tax:10090)	11848(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Pur-alpha regulates RhoA developmental expression and downstream signaling .
15464585	0	Pur_alpha	0,9	gata2	51,56	Pur alpha	gata2	19290(Tax:10090)	14461(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Pur_alpha and Sp8 as opposing regulators of neural gata2 expression .
15777709	0	Puralpha	0,8	PDGF-A	19,25	Puralpha	PDGF-A	19290(Tax:10090)	18590(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Puralpha activates PDGF-A gene transcription via interactions with a G-rich , single-stranded region of the promoter .
10364361	0	Puralpha	94,102	myelin_basic_protein	45,65	Puralpha	myelin basic protein	19290(Tax:10090)	17196(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Association of JC_virus large T antigen with myelin_basic_protein transcription factor -LRB- MEF-1 / Puralpha -RRB- in hypomyelinated brains of mice transgenically expressing T antigen .
10196137	0	Purkinje_cell_protein-2	53,76	Galphao	40,47	Purkinje cell protein-2	Galphao	18545(Tax:10090)	14681(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of heterotrimeric G protein Galphao with Purkinje_cell_protein-2 .
15187024	0	Puromycin-insensitive_leucyl-specific_aminopeptidase	0,52	PDK1	82,86	Puromycin-insensitive leucyl-specific aminopeptidase	PDK1	51752	5163	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Puromycin-insensitive_leucyl-specific_aminopeptidase -LRB- PILSAP -RRB- binds and catalyzes PDK1 , allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis .
18940788	0	Put3	43,47	MCH5	103,107	Put3	MCH5	853854(Tax:4932)	854483(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The proline-dependent transcription factor Put3 regulates the expression of the riboflavin transporter MCH5 in Saccharomyces_cerevisiae .
25335925	0	Pwp1	0,4	Stat3	100,105	Pwp1	Stat3	103136(Tax:10090)	20848(Tax:10090)	Gene	Gene	Required|nsubjpass|START_ENTITY Required|nmod|Signaling Signaling|compound|END_ENTITY	Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells Through Regulating Stat3 Signaling .
26876203	0	Pygo2	0,5	MDR1	16,20	Pygo2	MDR1	90780	5243	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Pygo2 activates MDR1 expression and mediates chemoresistance in breast_cancer via the Wnt/b-catenin pathway .
11158356	0	Pyk1	17,21	Pyruvate_kinase	0,15	Pyk1	Pyruvate kinase	851193(Tax:4932)	851193(Tax:4932)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Pyruvate_kinase -LRB- Pyk1 -RRB- levels influence both the rate and direction of carbon flux in yeast under fermentative conditions .
12771146	0	Pyk2	20,24	Arf1	35,39	Pyk2	Arf1	2185	375	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1 .
10356979	0	Pyk2	68,72	Beta2	0,5	Pyk2	Beta2	2185	10242	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Beta2 integrin-dependent phosphorylation of protein-tyrosine kinase Pyk2 stimulated by tumor_necrosis_factor_alpha and fMLP in human neutrophils adherent to fibrinogen .
10322114	0	Pyk2	16,20	EWS	109,112	Pyk2	EWS	2185	2130	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	Tyrosine kinase Pyk2 mediates G-protein-coupled receptor regulation of the Ewing_sarcoma RNA-binding protein EWS .
18391070	0	Pyk2	22,26	FAK	86,89	Pyk2	FAK	19229(Tax:10090)	14083(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK .
14585963	0	Pyk2	0,4	PDK1	52,56	Pyk2	PDK1	2185	5163	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Pyk2 - and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions .
12576483	0	Pyk2	35,39	Src	95,98	Pyk2	Src	19229(Tax:10090)	20779(Tax:10090)	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 .
22710711	0	Pyk2	17,21	TGF-b	0,5	Pyk2	TGF-b	5747	7040	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	TGF-b stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast_cancer .
18086875	0	Pyk2	81,85	Wrch1	24,29	Pyk2	Wrch1	2185	58480	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics .
10722671	0	Pyk2	48,52	angiotensin_II	56,70	Pyk2	angiotensin II	2185	183	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin_II in endothelial cells .
18667434	0	Pyk2	61,65	epidermal_growth_factor_receptor	19,51	Pyk2	epidermal growth factor receptor	2185	1956	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The transactivated epidermal_growth_factor_receptor recruits Pyk2 to regulate Src kinase activity .
12231407	0	Pyk2	40,44	focal_adhesion_kinase	68,89	Pyk2	focal adhesion kinase	2185	14083(Tax:10090)	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal_adhesion_kinase in osteoclasts .
17329398	0	Pyk2	15,19	leupaxin	38,46	Pyk2	leupaxin	2185	9404	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Pyk2 and PTP-PEST with leupaxin in prostate_cancer cells .
11278444	0	Pyk2	24,28	p38	57,60	Pyk2	p38	2185	1432	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Protein-tyrosine kinase Pyk2 mediates endothelin-induced p38 MAPK activation in glomerular mesangial cells .
19880522	0	Pyk2	0,4	p53	19,22	Pyk2	p53	19229(Tax:10090)	22060(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival .
11257449	0	Pyk2	14,18	p56	33,36	Pyk2	p56	2185	8999	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of Pyk2 expression by p56 -LRB- Lck -RRB- in Jurkat T lymphocytes .
12077257	0	Pyk2	55,59	proline-rich_tyrosine_kinase-2	23,53	Pyk2	proline-rich tyrosine kinase-2	2185	2185	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	TCR engagement induces proline-rich_tyrosine_kinase-2 -LRB- Pyk2 -RRB- translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion .
17551499	0	Pyk2	51,55	proline-rich_tyrosine_kinase2	20,49	Pyk2	proline-rich tyrosine kinase2	2185	2185	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The significance of proline-rich_tyrosine_kinase2 -LRB- Pyk2 -RRB- on hepatocellular_carcinoma progression and recurrence .
22096562	0	Pyk2	44,48	proline_rich_tyrosine_kinase_2	12,42	Pyk2	proline rich tyrosine kinase 2	19229(Tax:10090)	19229(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of proline_rich_tyrosine_kinase_2 -LRB- Pyk2 -RRB- on cisplatin resistance in hepatocellular_carcinoma .
26385349	0	Pyruvate_Kinase_Muscle_Isoenzyme_2	0,34	PKM2	36,40	Pyruvate Kinase Muscle Isoenzyme 2	PKM2	5315	5315	Gene	Gene	Expression|amod|START_ENTITY Expression|appos|END_ENTITY	Pyruvate_Kinase_Muscle_Isoenzyme_2 -LRB- PKM2 -RRB- Expression Is Associated with Overall Survival in Pancreatic_Ductal_Adenocarcinoma .
21809123	0	Pyruvate_dehydrogenase	0,22	TNFa	63,67	Pyruvate dehydrogenase	TNFa	54704	7124	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Pyruvate_dehydrogenase inhibition by the inflammatory cytokine TNFa contributes to the pathogenesis of pulmonary_arterial_hypertension .
19184109	0	Pyruvate_dehydrogenase_phosphatase_1	0,36	PDP1	38,42	Pyruvate dehydrogenase phosphatase 1	PDP1	54704	54704	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Pyruvate_dehydrogenase_phosphatase_1 -LRB- PDP1 -RRB- null mutation produces a lethal infantile phenotype .
11158356	0	Pyruvate_kinase	0,15	Pyk1	17,21	Pyruvate kinase	Pyk1	851193(Tax:4932)	851193(Tax:4932)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Pyruvate_kinase -LRB- Pyk1 -RRB- levels influence both the rate and direction of carbon flux in yeast under fermentative conditions .
26410533	0	Pyruvate_kinase_M2	0,18	DNA_damage-binding_protein_2	34,62	Pyruvate kinase M2	DNA damage-binding protein 2	5315	1643	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pyruvate_kinase_M2 interacts with DNA_damage-binding_protein_2 and reduces cell survival upon UV irradiation .
18191611	0	Pyruvate_kinase_isozyme_type_M2	0,31	Oct-4	69,74	Pyruvate kinase isozyme type M2	Oct-4	5315	5460	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Pyruvate_kinase_isozyme_type_M2 -LRB- PKM2 -RRB- interacts and cooperates with Oct-4 in regulating transcription .
25320454	0	Q10	30,33	Prosaposin	0,10	Q10	Prosaposin	27161	5660	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Prosaposin regulates coenzyme Q10 levels in HepG2 cells , especially those in mitochondria .
23321059	0	QKI	20,23	Glial_fibrillary_acidic_protein	34,65	QKI	Glial fibrillary acidic protein	9444	2670	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RNA-binding protein QKI regulates Glial_fibrillary_acidic_protein expression in human astrocytes .
26056009	0	QKI	62,65	miR-29a	0,7	QKI	miR-29a	9444	407021	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-29a promotes scavenger_receptor_A expression by targeting QKI -LRB- quaking -RRB- during monocyte-macrophage differentiation .
24793335	0	QR	32,34	quinone_reductase	13,30	QR	quinone reductase	12972(Tax:10090)	12972(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of quinone_reductase -LRB- QR -RRB- by withanolides isolated from Physalis angulata L. var .
9878249	0	QSCN6	22,27	quiescin_Q6	4,15	QSCN6	quiescin Q6	5768	5768	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The quiescin_Q6 gene -LRB- QSCN6 -RRB- is a fusion of two ancient gene families : thioredoxin and ERV1 .
24173806	0	QUIRKY	0,6	STRUBBELIG	22,32	QUIRKY	STRUBBELIG	843811(Tax:3702)	837654(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	QUIRKY interacts with STRUBBELIG and PAL_OF_QUIRKY to regulate cell growth anisotropy during Arabidopsis gynoecium development .
21253564	0	Quaking	0,7	Hnrnpa1	18,25	Quaking	Hnrnpa1	19317(Tax:10090)	3178	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Quaking regulates Hnrnpa1 expression through its 3 ' UTR in oligodendrocyte precursor cells .
1692389	0	Quaking	0,7	jimpy	8,13	Quaking	jimpy	19317(Tax:10090)	18823(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Quaking * jimpy double mutant mice : additional evidence for independence of primary deficits in jimpy .
7518443	0	R-PTP-alpha	30,41	Grb2	109,113	R-PTP-alpha	Grb2	5786	2885	Gene	Gene	tyrosine-phosphorylated|nsubjpass|START_ENTITY tyrosine-phosphorylated|nmod|END_ENTITY	Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2 .
10803462	0	R-Ras3	0,6	Akt	56,59	R-Ras3	Akt	22808	24185(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	R-Ras3 , a brain-specific Ras-related protein , activates Akt and promotes cell survival in PC12 cells .
12138204	0	R-Ras3	0,6	M-Ras	7,12	R-Ras3	M-Ras	22808	25482(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	R-Ras3 / M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade .
22820501	0	R-cadherin	27,37	Rho	13,16	R-cadherin	Rho	1002	6010	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Small GTPase Rho regulates R-cadherin through Dia1/profilin -1 .
15117735	0	R-cadherin	0,10	beta-catenin	11,23	R-cadherin	beta-catenin	1002	1499	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	R-cadherin : beta-catenin complex and its association with vascular smooth muscle cell proliferation .
10471788	0	R-esp1	0,6	groucho	38,45	R-esp1	groucho	29466(Tax:10116)	43162(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	R-esp1 , a rat homologue of drosophila groucho , is differentially expressed after optic nerve crush and mediates NGF-induced survival of PC12 cells .
18242177	0	R-spondin1	0,10	Wnt3A	27,32	R-spondin1	Wnt3A	192199(Tax:10090)	22416(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression .
19768455	0	R-spondin1	101,111	aryl_hydrocarbon_receptor	127,152	R-spondin1	aryl hydrocarbon receptor	284654	196	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibitory effects of cigarette_smoke_extract on neural crest migration occur through suppression of R-spondin1 expression via aryl_hydrocarbon_receptor .
25178409	0	R-spondin_1	55,66	RSPO1	68,73	R-spondin 1	RSPO1	284654	284654	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	The association of radiographic progression with serum R-spondin_1 -LRB- RSPO1 -RRB- levels or Dickkopf-1 -LRB- DKK1 -RRB- / RSPO1 ratios in rheumatoid_arthritis patients : clinical evidence for reciprocal inhibition between DKK1 and RSPO1 .
26123262	0	R-spondin_2	21,32	LGR5	82,86	R-spondin 2	LGR5	340419	8549	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of R-spondin_2 in complex with the ectodomains of its receptors LGR5 and ZNRF3 .
26123262	0	R-spondin_2	21,32	LGR5	82,86	R-spondin 2	LGR5	340419	8549	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of R-spondin_2 in complex with the ectodomains of its receptors LGR5 and ZNRF3 .
19213727	0	R-spondin_2	64,75	Wnt11	0,5	R-spondin 2	Wnt11	340419	7481	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Wnt11 promotes osteoblast maturation and mineralization through R-spondin_2 .
21566199	0	R1663	108,113	factor_Xa	123,132	R1663	factor Xa	174621(Tax:6239)	2159	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Crossover dose escalation study to assess safety , pharmacokinetics , and pharmacodynamics of single doses of R1663 , an oral factor_Xa inhibitor , in healthy male volunteers .
22552265	0	R1663	77,82	factor_Xa	92,101	R1663	factor Xa	174621(Tax:6239)	2159	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Safety , pharmacokinetics and pharmacodynamics of multiple ascending doses of R1663 , an oral factor_Xa inhibitor , in healthy young subjects coupled with exploration of influence of gender and age .
15085313	0	R1_and_Puv_II	85,98	Sp_1	48,52	R1 and Puv II	Sp 1	910	6667	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	The relationship between COLI A1 polymorphisms -LRB- Sp_1 -RRB- and COLI A2 polymorphisms -LRB- Eco R1_and_Puv_II -RRB- with bone_mineral_density in Chinese men and women .
11359771	0	RA-GEF-1	0,8	Rap1	51,55	RA-GEF-1	Rap1	9693	5906	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	RA-GEF-1 , a guanine_nucleotide exchange factor for Rap1 , is activated by translocation induced by association with Rap1 * GTP and enhances Rap1-dependent B-Raf activation .
20573983	0	RAB-10	22,28	EHBP-1	0,6	RAB-10	EHBP-1	266836(Tax:6239)	179343(Tax:6239)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis_elegans .
15895077	0	RAB-5	53,58	RME-6	23,28	RAB-5	RME-6	172755(Tax:6239)	180463(Tax:6239)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Caenorhabditis_elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit .
19542357	0	RAB-5	111,116	TBC-2	41,46	RAB-5	TBC-2	172755(Tax:6239)	173986(Tax:6239)	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	C. _ elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5 .
22558469	0	RAB-7	0,5	EGFR	25,29	RAB-7	EGFR	174834(Tax:6239)	1956	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis_elegans .
17203072	0	RAB-7	47,52	SAND-1	23,29	RAB-7	SAND-1	174834(Tax:6239)	177318(Tax:6239)	Gene	Gene	function|compound|START_ENTITY essential|nmod|function essential|nsubj|END_ENTITY	Caenorhabditis_elegans SAND-1 is essential for RAB-7 function in endosomal traffic .
16147880	0	RAB18	76,81	Rab18	64,69	RAB18	Rab18	22931	22931	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a novel splice variant of human Rab18 gene -LRB- RAB18 -RRB- .
26977884	0	RAB1B	17,22	PITPNC1	0,7	RAB1B	PITPNC1	81876	26207	Gene	Gene	START_ENTITY|nsubj|Recruits Recruits|compound|END_ENTITY	PITPNC1 Recruits RAB1B to the Golgi Network to Drive Malignant Secretion .
26382657	0	RAB22A	70,76	miR-203	0,7	RAB22A	miR-203	57403	406986	Gene	Gene	Acts|nmod|START_ENTITY Acts|amod|END_ENTITY	miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A .
16596256	0	RAB24	6,11	cyclophilin_A	107,120	RAB24	cyclophilin A	53917	5478	Gene	Gene	colocalized|nsubjpass|START_ENTITY colocalized|nmod|END_ENTITY	Human RAB24 , interestingly and predominantly distributed in the nuclei of COS-7 cells , is colocalized with cyclophilin_A and GABARAP .
20038531	0	RAB26	0,5	MIST1	54,59	RAB26	MIST1	25837	168620	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation .
18281284	0	RAB27A	57,63	Microphthalmia-associated_transcription_factor	0,46	RAB27A	Microphthalmia-associated transcription factor	5873	4286	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Microphthalmia-associated_transcription_factor regulates RAB27A gene expression and controls melanosome transport .
23395371	0	RAB7L1	0,6	LRRK2	22,27	RAB7L1	LRRK2	8934	120892	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson 's _ disease risk .
24892806	0	RAB8A	26,31	Myosin_Vb	0,9	RAB8A	Myosin Vb	4218	4645	Gene	Gene	elicits|compound|START_ENTITY uncoupling|nmod|elicits END_ENTITY|acl|uncoupling	Myosin_Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease .
11136552	0	RABGGTA	138,145	Rab_geranylgeranyl_transferase_alpha-subunit	92,136	RABGGTA	Rab geranylgeranyl transferase alpha-subunit	5875	5875	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	5 ' - UTR structural organization , transcript expression , and mutational analysis of the human Rab_geranylgeranyl_transferase_alpha-subunit -LRB- RABGGTA -RRB- gene .
11294891	0	RAC1	0,4	E-cadherin	57,67	RAC1	E-cadherin	5879	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|endocytosis endocytosis|nmod|END_ENTITY	RAC1 regulates adherens junctions through endocytosis of E-cadherin .
25311989	0	RAC1	19,23	PI3K	0,4	RAC1	PI3K	19353(Tax:10090)	18708(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice .
25384218	0	RAC1	17,21	RASAL2	0,6	RAC1	RASAL2	5879	9462	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	RASAL2 activates RAC1 to promote triple-negative_breast_cancer progression .
22358380	0	RAC1	58,62	Ras-related_C3_botulinum_toxin_substrate_1	14,56	RAC1	Ras-related C3 botulinum toxin substrate 1	5879	5879	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Ras-related_C3_botulinum_toxin_substrate_1 -LRB- RAC1 -RRB- in human cholesteatoma .
25295536	0	RAC1	65,69	TRPM2	0,5	RAC1	TRPM2	19353(Tax:10090)	28240(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	TRPM2 mediates ischemic_kidney_injury and oxidant stress through RAC1 .
21217774	0	RAC3	0,4	ERa	40,43	RAC3	ERa	5881	2099	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	RAC3 is a pro-migratory co-activator of ERa .
24462857	0	RACK-1	69,75	THP-1	100,105	RACK-1	THP-1	10399	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Corticosteroids modulate the expression of the PKC-anchoring protein RACK-1 and cytokine release in THP-1 cells .
24776851	0	RACK-1	0,6	let-7	17,22	RACK-1	let-7	177895(Tax:6239)	266952(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis_elegans .
25792604	0	RACK1	23,28	Asc1	0,4	RACK1	Asc1	10399	56301	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Asc1 , homolog of human RACK1 , prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats .
20410295	0	RACK1	69,74	BDNF	25,29	RACK1	BDNF	10399	627	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Epigenetic regulation of BDNF expression via the scaffolding protein RACK1 .
21885037	0	RACK1	0,5	BDNF	34,38	RACK1	BDNF	14694(Tax:10090)	12064(Tax:10090)	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|reward reward|nmod|END_ENTITY	RACK1 affects morphine reward via BDNF .
10849009	0	RACK1	26,31	BZLF1	88,93	RACK1	BZLF1	10399	3783744(Tax:10376)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The PKC targeting protein RACK1 interacts with the Epstein-Barr_virus activator protein BZLF1 .
17409124	0	RACK1	29,34	CFTR	59,63	RACK1	CFTR	10399	1080	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the scaffold protein RACK1 in apical expression of CFTR .
19785988	0	RACK1	0,5	CLEC-2	22,28	RACK1	CLEC-2	14694(Tax:10090)	56760(Tax:10090)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation .
24947010	0	RACK1	20,25	DJ-1	0,4	RACK1	DJ-1	10399	11315	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis .
23651062	0	RACK1	0,5	FBW2	57,61	RACK1	FBW2	10399	26190	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RACK1 -LRB- receptor_for_activated_C-kinase_1 -RRB- interacts with FBW2 -LRB- F-box and WD-repeat domain-containing 2 -RRB- to up-regulate GCM1 -LRB- glial_cell_missing_1 -RRB- stability and placental cell migration and invasion .
10490850	0	RACK1	15,20	GM-CSF	77,83	RACK1	GM-CSF	10399	1437	Gene	Gene	Association|nmod|START_ENTITY Association|parataxis|IL-3 IL-3|dep|receptor receptor|amod|END_ENTITY	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
17244529	0	RACK1	0,5	HSP90	20,25	RACK1	HSP90	10399	3320	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O -LRB- 2 -RRB- - independent and HSP90 inhibitor-induced degradation of HIF-1alpha .
10490850	0	RACK1	15,20	IL-5	67,71	RACK1	IL-5	10399	3567	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of RACK1 and PKCbeta with the common beta-chain of the IL-5 / IL-3 / GM-CSF receptor .
20103773	0	RACK1	19,24	IRE1alpha	65,74	RACK1	IRE1alpha	14694(Tax:10090)	78943(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells .
16061178	0	RACK1	0,5	JNK	29,32	RACK1	JNK	14694(Tax:10090)	26419(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	RACK1 mediates activation of JNK by protein_kinase_C -LSB- corrected -RSB- .
26137143	0	RACK1	0,5	JNK	32,35	RACK1	JNK	10399	5599	Gene	Gene	expression|compound|START_ENTITY contributes|nsubj|expression contributes|xcomp|END_ENTITY	RACK1 expression contributes to JNK activity , but JNK activity does not enhance RACK1 expression in hepatocellular_carcinoma SMMC-7721 cells .
26137143	0	RACK1	80,85	JNK	50,53	RACK1	JNK	10399	5599	Gene	Gene	expression|nummod|START_ENTITY enhance|dobj|expression enhance|nsubj|activity activity|compound|END_ENTITY	RACK1 expression contributes to JNK activity , but JNK activity does not enhance RACK1 expression in hepatocellular_carcinoma SMMC-7721 cells .
24167714	0	RACK1	62,67	MELK	37,41	RACK1	MELK	495666(Tax:8355)	397927(Tax:8355)	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme-like cells in Xenopus embryo .
16920332	0	RACK1	0,5	NHE5	22,26	RACK1	NHE5	10399	6553	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity .
15075202	0	RACK1	68,73	NHERF1	25,31	RACK1	NHERF1	10399	9368	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of a PDZ1 domain of NHERF1 in the binding of airway epithelial RACK1 to NHERF1 .
16922502	0	RACK1	42,47	NHERF1	75,81	RACK1	NHERF1	10399	9368	Gene	Gene	repeat|nmod|START_ENTITY N-terminus|nmod|repeat binds|nsubj|N-terminus binds|xcomp|airway airway|dobj|END_ENTITY	The N-terminus of the WD5 repeat of human RACK1 binds to airway epithelial NHERF1 .
24726876	0	RACK1	35,40	PP2A	27,31	RACK1	PP2A	10399	5524	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling .
16382134	0	RACK1	0,5	STAT3	15,20	RACK1	STAT3	10399	6774	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	RACK1 recruits STAT3 specifically to insulin_and_insulin-like_growth_factor_1_receptors for activation , which is important for regulating anchorage-independent growth .
15184885	0	RACK1	0,5	Sam68	29,34	RACK1	Sam68	14694(Tax:10090)	20218(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling .
16849317	0	RACK1	0,5	Smad3	15,20	RACK1	Smad3	10399	4088	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	RACK1 binds to Smad3 to modulate transforming_growth_factor-beta1-stimulated alpha2 -LRB- I -RRB- _ collagen transcription in renal tubular epithelial cells .
12400005	0	RACK1	0,5	Src	33,36	RACK1	Src	14694(Tax:10090)	20779(Tax:10090)	Gene	Gene	START_ENTITY|dep|substrate substrate|nmod|kinase kinase|compound|END_ENTITY	RACK1 : a novel substrate for the Src protein-tyrosine kinase .
15254245	0	RACK1	0,5	Src	48,51	RACK1	Src	14694(Tax:10090)	20779(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|suppressing suppressing|dobj|activity activity|compound|END_ENTITY	RACK1 regulates G1/S progression by suppressing Src kinase activity .
17574549	0	RACK1	0,5	Src	16,19	RACK1	Src	10399	6714	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	RACK1 regulates Src activity and modulates paxillin dynamics during cell migration .
19767770	0	RACK1	34,39	Src	56,59	RACK1	Src	14694(Tax:10090)	20779(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|dep|suppression suppression|nmod|activity activity|compound|END_ENTITY	A novel pro-apoptotic function of RACK1 : suppression of Src activity in the intrinsic and Akt pathways .
20483033	0	RACK1	0,5	Src	54,57	RACK1	Src	14694(Tax:10090)	20779(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|re-exposure re-exposure|nmod|inhibition inhibition|nmod|END_ENTITY	RACK1 inhibits morphine re-exposure via inhibition of Src .
24681954	0	RACK1	53,58	TRIM45	22,28	RACK1	TRIM45	10399	80263	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway .
12958311	0	RACK1	24,29	androgen_receptor	45,62	RACK1	androgen receptor	10399	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The scaffolding protein RACK1 interacts with androgen_receptor and promotes cross-talk through a protein_kinase_C signaling pathway .
17108144	0	RACK1	35,40	androgen_receptor	108,125	RACK1	androgen receptor	10399	367	Gene	Gene	Receptor_for_activated_C_kinase_1|appos|START_ENTITY regulate|nsubj|Receptor_for_activated_C_kinase_1 regulate|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Receptor_for_activated_C_kinase_1 -LRB- RACK1 -RRB- and Src regulate the tyrosine phosphorylation and function of the androgen_receptor .
23636454	0	RACK1	0,5	filamin-A	21,30	RACK1	filamin-A	10399	2316	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RACK1 interacts with filamin-A to regulate plasma membrane levels of the cystic_fibrosis_transmembrane_conductance_regulator .
26038599	0	RACK1	21,26	p38_MAPK	70,78	RACK1	p38 MAPK	14694(Tax:10090)	26416(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	The scaffold protein RACK1 mediates the RANKL-dependent activation of p38_MAPK in osteoclast precursors .
17201176	0	RACK1	96,101	receptor_for_activated_C-kinase_1	61,94	RACK1	receptor for activated C-kinase 1	10399	10399	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The prion-like protein Doppel -LRB- Dpl -RRB- interacts with the human receptor_for_activated_C-kinase_1 -LRB- RACK1 -RRB- protein .
9584165	0	RACK1	0,5	src	111,114	RACK1	src	14694(Tax:10090)	20779(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|kinases kinases|compound|END_ENTITY	RACK1 , a receptor_for_activated_C_kinase and a homolog of the beta subunit of G proteins , inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells .
16843491	0	RAD-51	39,45	CeBRC-2	0,7	RAD-51	CeBRC-2	177914(Tax:6239)	175962(Tax:6239)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing .
18727386	0	RAD17	44,49	RAD24	51,56	RAD17	RAD24	854550(Tax:4932)	856920(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
18825953	0	RAD17	44,49	RAD24	51,56	RAD17	RAD24	854550(Tax:4932)	856920(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
9725831	0	RAD17	35,40	RAD24	42,47	RAD17	RAD24	854550(Tax:4932)	856920(Tax:4932)	Gene	Gene	RAD9|nummod|START_ENTITY RAD9|nummod|END_ENTITY	The Saccharomyces_cerevisiae RAD9 , RAD17 , RAD24 and MEC3 genes are required for tolerating irreparable , ultraviolet-induced DNA damage .
18727386	0	RAD17	44,49	RAD9	38,42	RAD17	RAD9	854550(Tax:4932)	851803(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
18825953	0	RAD17	44,49	RAD9	38,42	RAD17	RAD9	854550(Tax:4932)	851803(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
21884979	0	RAD18	14,19	NBS1	0,4	RAD18	NBS1	56852	4683	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol - dependent translesion DNA synthesis .
24326185	0	RAD2	6,10	XPG	31,34	RAD2	XPG	2237	2073	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Yeast RAD2 , a homolog of human XPG , plays a key role in the regulation of the cell cycle and actin dynamics .
25575569	0	RAD21	13,18	APOB	41,45	RAD21	APOB	5885	338	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	Mutations in RAD21 Disrupt Regulation of APOB in Patients With Chronic_Intestinal_Pseudo-Obstruction .
9636371	0	RAD23	56,61	HHR23A	0,6	RAD23	HHR23A	856674(Tax:4932)	5886	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	HHR23A , the human homologue of the yeast repair protein RAD23 , interacts specifically with Vpr protein and prevents cell cycle arrest but not the transcriptional effects of Vpr .
24318982	0	RAD23	82,87	hHR23A	89,95	RAD23	hHR23A	856674(Tax:4932)	5886	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 -LRB- hHR23A -RRB- requires its xeroderma_pigmentosum complementation group C binding -LRB- XPCB -RRB- domain as well as the ubiquitin-associated_2 -LRB- UBA2 -RRB- domain .
18727386	0	RAD24	51,56	RAD17	44,49	RAD24	RAD17	856920(Tax:4932)	854550(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
18825953	0	RAD24	51,56	RAD17	44,49	RAD24	RAD17	856920(Tax:4932)	854550(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
9725831	0	RAD24	42,47	RAD17	35,40	RAD24	RAD17	856920(Tax:4932)	854550(Tax:4932)	Gene	Gene	RAD9|nummod|START_ENTITY RAD9|nummod|END_ENTITY	The Saccharomyces_cerevisiae RAD9 , RAD17 , RAD24 and MEC3 genes are required for tolerating irreparable , ultraviolet-induced DNA damage .
18727386	0	RAD24	51,56	RAD9	38,42	RAD24	RAD9	856920(Tax:4932)	851803(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
18825953	0	RAD24	51,56	RAD9	38,42	RAD24	RAD9	856920(Tax:4932)	851803(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
8846774	0	RAD24	50,55	rad17	14,19	RAD24	rad17	856920(Tax:4932)	854550(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|dep|homologue	Fission_yeast rad17 : a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins .
12750242	0	RAD51	49,54	BRCA1	90,95	RAD51	BRCA1	5888	672	Gene	Gene	polymorphism|compound|START_ENTITY associated|nmod|polymorphism associated|nmod|carriers carriers|nmod|mutation mutation|compound|END_ENTITY	Breast_cancer risk reduction associated with the RAD51 polymorphism among carriers of the BRCA1 5382insC mutation in Poland .
16165098	0	RAD51	70,75	BRCA1	25,30	RAD51	BRCA1	5888	672	Gene	Gene	assembly|nmod|START_ENTITY required|nmod|assembly required|nsubjpass|carboxyl-terminal carboxyl-terminal|nmod|END_ENTITY	The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast_and_ovarian_cancer cells .
16357146	0	RAD51	16,21	BRCA1	0,5	RAD51	BRCA1	5888	672	Gene	Gene	function|nummod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage : implications for sister chromatid cohesion , genome stability , and carcinogenesis .
16477874	0	RAD51	83,88	BRCA1	9,14	RAD51	BRCA1	5888	672	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene untranslated|dobj|region mutations|acl|untranslated mutations|compound|END_ENTITY	Germline BRCA1 mutations and G/C polymorphism in the 5 ' - untranslated region of the RAD51 gene in Polish women with breast_cancer .
17301259	0	RAD51	4,9	BRCA1	88,93	RAD51	BRCA1	5888	672	Gene	Gene	polymorphism|compound|START_ENTITY modifies|nsubj|polymorphism modifies|dobj|risk risk|nmod|carriers carriers|compound|END_ENTITY	The RAD51 135_G > C polymorphism modifies breast_cancer and ovarian_cancer risk in Polish BRCA1 mutation carriers .
22865450	0	RAD51	27,32	BRCA1	79,84	RAD51	BRCA1	5888	672	Gene	Gene	assembly|nmod|START_ENTITY regulates|dobj|assembly regulates|nmod|breaks breaks|nmod|absence absence|nmod|END_ENTITY	RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1 .
11239456	0	RAD51	32,37	BRCA2	8,13	RAD51	BRCA2	5888	675	Gene	Gene	recombination|compound|START_ENTITY Role|nmod|recombination Role|nmod|END_ENTITY	Role of BRCA2 in control of the RAD51 recombination and DNA_repair_protein .
11248061	0	RAD51	40,45	BRCA2	75,80	RAD51	BRCA2	5888	675	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene modifies|nsubj|polymorphism modifies|dobj|risk risk|nmod|END_ENTITY	A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers .
12941707	0	RAD51	65,70	BRCA2	95,100	RAD51	BRCA2	5888	675	Gene	Gene	assembly|compound|START_ENTITY assembly|nmod|END_ENTITY	Full-length archaeal Rad51 structure and mutants : mechanisms for RAD51 assembly and control by BRCA2 .
15138485	0	RAD51	40,45	BRCA2	82,87	RAD51	BRCA2	5888	675	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene modifies|nsubj|polymorphism modifies|nmod|carriers carriers|nummod|END_ENTITY	A single-nucleotide polymorphism in the RAD51 gene modifies breast_cancer risk in BRCA2 carriers , but not in BRCA1 carriers or noncarriers .
15703751	0	RAD51	35,40	BRCA2	4,9	RAD51	BRCA2	5888	675	Gene	Gene	formation|compound|START_ENTITY nucleates|dobj|formation nucleates|nsubj|Brh2 Brh2|compound|END_ENTITY	The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction .
17515904	0	RAD51	17,22	BRCA2	75,80	RAD51	BRCA2	5888	675	Gene	Gene	nucleoprotein|compound|START_ENTITY Stabilization|nmod|nucleoprotein filaments|nsubj|Stabilization filaments|nmod|region region|nmod|END_ENTITY	Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 .
17999359	0	RAD51	0,5	BRCA2	49,54	RAD51	BRCA2	5888	675	Gene	Gene	135G|compound|START_ENTITY 135G|dep|risk risk|nmod|carriers carriers|compound|END_ENTITY	RAD51 135G -- > C modifies breast_cancer risk among BRCA2 mutation carriers : results from a combined analysis of 19 studies .
18429825	0	RAD51	37,42	BRCA2	51,56	RAD51	BRCA2	5888	675	Gene	Gene	BRCA1|compound|START_ENTITY polymorphisms|nmod|BRCA1 END_ENTITY|nsubj|polymorphisms	Dinucleotide repeat polymorphisms of RAD51 , BRCA1 , BRCA2 gene regions in breast_cancer .
19303847	0	RAD51	65,70	BRCA2	19,24	RAD51	BRCA2	5888	675	Gene	Gene	selectivity|nmod|START_ENTITY modulate|dobj|selectivity modulate|nsubj|repeats repeats|nmod|END_ENTITY	The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51 .
19628690	0	RAD51	55,60	BRCA2	25,30	RAD51	BRCA2	5888	675	Gene	Gene	binding|compound|START_ENTITY regulate|dobj|binding regulate|nsubj|repeats repeats|nmod|END_ENTITY	The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single - versus double-stranded DNA to stimulate strand exchange .
19875419	0	RAD51	96,101	BRCA2	34,39	RAD51	BRCA2	5888	675	Gene	Gene	recombinase|compound|START_ENTITY repeats|nmod|recombinase repeats|nmod|interactions interactions|compound|END_ENTITY	Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase .
20684611	0	RAD51	37,42	BRCA2	78,83	RAD51	BRCA2	5888	675	Gene	Gene	recombinase|compound|START_ENTITY recombinase|acl|based based|nmod|motifs motifs|nmod|protein protein|compound|END_ENTITY	Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein : modeling and experimental validation of a chimera peptide .
20729858	0	RAD51	76,81	BRCA2	35,40	RAD51	BRCA2	5888	675	Gene	Gene	specific|nmod|START_ENTITY promotes|dobj|specific promotes|nsubj|END_ENTITY	The breast_cancer_tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA .
20729859	0	RAD51	29,34	BRCA2	6,11	RAD51	BRCA2	5888	675	Gene	Gene	formation|compound|START_ENTITY promotes|dobj|formation promotes|nsubj|protein protein|compound|END_ENTITY	Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA .
21076401	0	RAD51	16,21	BRCA2	0,5	RAD51	BRCA2	5888	675	Gene	Gene	loader|compound|START_ENTITY facilitate|nsubj|loader acts|advcl|facilitate acts|nsubj|END_ENTITY	BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping .
21576230	0	RAD51	35,40	BRCA2	14,19	RAD51	BRCA2	5888	675	Gene	Gene	filaments|nummod|START_ENTITY domain|nmod|filaments domain|compound|END_ENTITY	Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques .
21670257	0	RAD51	44,49	BRCA2	30,35	RAD51	BRCA2	5888	675	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms .
22077663	0	RAD51	23,28	BRCA2	0,5	RAD51	BRCA2	832208(Tax:3702)	675	Gene	Gene	recombination|amod|START_ENTITY mediator|nmod|recombination mediator|nsubj|END_ENTITY	BRCA2 is a mediator of RAD51 - and DMC1-facilitated homologous recombination in Arabidopsis_thaliana .
23384538	0	RAD51	26,31	BRCA2	0,5	RAD51	BRCA2	5888	675	Gene	Gene	paralogs|nummod|START_ENTITY epistatic|nmod|paralogs epistatic|nsubj|END_ENTITY	BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage .
25488918	0	RAD51	43,48	BRCA2	0,5	RAD51	BRCA2	5888	675	Gene	Gene	diffuses|nmod|START_ENTITY diffuses|nsubj|END_ENTITY	BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells .
25778924	0	RAD51	43,48	BRCA2	0,5	RAD51	BRCA2	5888	675	Gene	Gene	diffuses|nmod|START_ENTITY diffuses|nsubj|END_ENTITY	BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells .
25876666	0	RAD51	69,74	BRCA2	24,29	RAD51	BRCA2	403568(Tax:9615)	474180(Tax:9615)	Gene	Gene	affecting|nmod|START_ENTITY repeats|xcomp|affecting repeats|nsubj|Polymorphisms Polymorphisms|nmod|BRC BRC|compound|END_ENTITY	Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51 .
25876666	0	RAD51	69,74	BRCA2	24,29	RAD51	BRCA2	403568(Tax:9615)	474180(Tax:9615)	Gene	Gene	affecting|nmod|START_ENTITY repeats|xcomp|affecting repeats|nsubj|Polymorphisms Polymorphisms|nmod|BRC BRC|compound|END_ENTITY	Polymorphisms of canine BRCA2 BRC repeats affecting interaction with RAD51 .
26992456	0	RAD51	75,80	BRCA2	81,86	BRCA2	RAD51	675	5888	Gene	Gene	Relationship|dep|START_ENTITY Relationship|dep|Interaction Interaction|compound|END_ENTITY	Structure Activity Relationship of the Peptide Binding Motif Mediating the RAD51 : BRCA2 Protein-Protein Interaction .
27084934	0	RAD51	41,46	BRCA2	20,25	RAD51	BRCA2	5888	675	Gene	Gene	sensitivity|compound|START_ENTITY repeats|nmod|sensitivity repeats|nsubj|Distinct Distinct|nmod|BRC BRC|compound|END_ENTITY	Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity .
9192668	0	RAD51	75,80	BRCA2	23,28	RAD51	BRCA2	19361(Tax:10090)	12190(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY interact|nmod|protein proteins|acl:relcl|interact END_ENTITY|dep|proteins	RAB22 and RAB163/mouse BRCA2 : proteins that specifically interact with the RAD51 protein .
9523196	0	RAD51	69,74	BRCA2	27,32	RAD51	BRCA2	5888	675	Gene	Gene	interacting|nmod|START_ENTITY sites|acl|interacting sites|nmod|END_ENTITY	Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51 .
9560268	0	RAD51	42,47	BRCA2	19,24	RAD51	BRCA2	5888	675	Gene	Gene	binding|compound|START_ENTITY critical|nmod|binding critical|nsubj|repeats repeats|nmod|END_ENTITY	The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl_methanesulfonate treatment .
19329439	0	RAD51	46,51	EVL	87,90	RAD51	EVL	5888	51466	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Recombination activator function of the novel RAD51 - and RAD51B-binding protein , human EVL .
20403813	0	RAD51	32,37	GEMIN2	0,6	RAD51	GEMIN2	5888	8487	Gene	Gene	accumulation|nmod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination .
24798879	0	RAD51	44,49	Nap1	0,4	RAD51	Nap1	5888	4673	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1 .
19447914	0	RAD51	19,24	PSF	6,9	RAD51	PSF	5888	3490	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities .
10871607	0	RAD51	4,9	RAD51L3	25,32	RAD51	RAD51L3	5888	5892	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	The RAD51 family member , RAD51L3 , is a DNA-stimulated ATPase that forms a complex with XRCC2 .
9405383	0	RAD51	0,5	brca2	108,113	RAD51	brca2	5888	675	Gene	Gene	interacts|nummod|START_ENTITY conserved|nsubj|interacts conserved|nmod|END_ENTITY	RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast_cancer susceptibility gene brca2 .
19285032	0	RAD51	33,38	c-ABL	0,5	RAD51	c-ABL	5888	25	Gene	Gene	association|nummod|START_ENTITY stabilizes|dobj|association stabilizes|nsubj|kinase kinase|amod|END_ENTITY	c-ABL tyrosine kinase stabilizes RAD51 chromatin association .
26980768	0	RAD51	69,74	histone_deacetylase	9,28	RAD51	histone deacetylase	5888	9734	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Enhanced histone_deacetylase activity in malignant_melanoma provokes RAD51 and FANCD2 triggered drug resistance .
10092526	0	RAD51	115,120	rec_A	109,114	RAD51	rec A	19361(Tax:10090)	19361(Tax:10090)	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene , a member of the rec_A / RAD51 gene family .
21903585	0	RAD51-associated_protein_1	0,26	DMC1	77,81	RAD51-associated protein 1	DMC1	10635	11144	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RAD51-associated_protein_1 -LRB- RAD51AP1 -RRB- interacts with the meiotic recombinase DMC1 through a conserved motif .
11744692	0	RAD51B	22,28	RAD51C	0,6	RAD51B	RAD51C	5890	5889	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51 .
11744692	0	RAD51C	0,6	RAD51B	22,28	RAD51C	RAD51B	5889	5890	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51 .
11912211	0	RAD51C	27,33	RAD51L2	18,25	RAD51C	RAD51L2	5889	5889	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of mammalian RAD51L2 -LRB- RAD51C -RRB- in recombination and genetic stability .
12966089	0	RAD51C	53,59	RAD51L2	44,51	RAD51C	RAD51L2	5889	5889	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of functional domains in the RAD51L2 -LRB- RAD51C -RRB- protein and its requirement for gene conversion .
11912211	0	RAD51L2	18,25	RAD51C	27,33	RAD51L2	RAD51C	5889	5889	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of mammalian RAD51L2 -LRB- RAD51C -RRB- in recombination and genetic stability .
12966089	0	RAD51L2	44,51	RAD51C	53,59	RAD51L2	RAD51C	5889	5889	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of functional domains in the RAD51L2 -LRB- RAD51C -RRB- protein and its requirement for gene conversion .
10871607	0	RAD51L3	25,32	RAD51	4,9	RAD51L3	RAD51	5892	5888	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	The RAD51 family member , RAD51L3 , is a DNA-stimulated ATPase that forms a complex with XRCC2 .
19506022	0	RAD52	26,31	OGG1	76,80	RAD52	OGG1	5893	4968	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells .
8921390	0	RAD52	27,32	UBL1	34,38	RAD52	UBL1	5893	7341	Gene	Gene	p53|compound|START_ENTITY p53|dep|END_ENTITY	Associations of UBE2I with RAD52 , UBL1 , p53 , and RAD51 proteins in a yeast two-hybrid system .
12750383	0	RAD52	82,87	WRN	0,3	RAD52	WRN	5893	7486	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	WRN interacts physically and functionally with the recombination mediator protein RAD52 .
10362364	0	RAD54	27,32	RAD54B	44,50	RAD54	RAD54B	8438	25788	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Mutations of a novel human RAD54 homologue , RAD54B , in primary cancer .
9409819	0	RAD54	9,14	RDH54	0,5	RAD54	RDH54	852713(Tax:4932)	852365(Tax:4932)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	RDH54 , a RAD54 homologue in Saccharomyces_cerevisiae , is required for mitotic diploid-specific recombination and repair and for meiosis .
10362364	0	RAD54B	44,50	RAD54	27,32	RAD54B	RAD54	25788	8438	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Mutations of a novel human RAD54 homologue , RAD54B , in primary cancer .
1902572	0	RAD6	56,60	Dhr6	0,4	RAD6	Dhr6	852822(Tax:4932)	40610(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Dhr6 , a Drosophila homolog of the yeast DNA-repair gene RAD6 .
18727386	0	RAD9	38,42	RAD17	44,49	RAD9	RAD17	851803(Tax:4932)	854550(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
18825953	0	RAD9	38,42	RAD17	44,49	RAD9	RAD17	851803(Tax:4932)	854550(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
18727386	0	RAD9	38,42	RAD24	51,56	RAD9	RAD24	851803(Tax:4932)	856920(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
18825953	0	RAD9	38,42	RAD24	51,56	RAD9	RAD24	851803(Tax:4932)	856920(Tax:4932)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Interaction between checkpoint genes RAD9 , RAD17 , RAD24 , and RAD53 involved in the determination of yeast Saccharomyces_cerevisiae sensitivity to ionizing radiation -RSB- .
16926493	0	RADICAL-INDUCED_CELL_DEATH1	22,49	RCD1	51,55	RADICAL-INDUCED CELL DEATH1	RCD1	840115(Tax:3702)	840115(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Overexpression of the RADICAL-INDUCED_CELL_DEATH1 -LRB- RCD1 -RRB- gene of Arabidopsis causes weak rcd1 phenotype with compromised oxidative-stress responses .
20703093	0	RAF	0,3	BubR1	43,48	RAF	BubR1	22882	701	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition .
14517245	0	RAF	22,25	CNK	29,32	RAF	CNK	31221(Tax:7227)	36952(Tax:7227)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bimodal regulation of RAF by CNK in Drosophila .
22763439	0	RAF	54,57	HGF	77,80	RAF	HGF	22882	3082	Gene	Gene	inhibitors|compound|START_ENTITY innate|nmod|inhibitors innate|nmod|secretion secretion|compound|END_ENTITY	Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion .
24434899	0	RAF	83,86	HGF	22,25	RAF	HGF	22882	3082	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Evaluation of stromal HGF immunoreactivity as a biomarker for melanoma response to RAF inhibitors .
25490933	0	RAF	73,76	HGF	96,99	RAF	HGF	22882	3082	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Registered report : Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion .
15930308	0	RAF	28,31	MEK	34,37	RAF	MEK	22882	5609	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|dep|END_ENTITY	Pharmacologic inhibition of RAF -- > MEK -- > ERK signaling elicits pancreatic_cancer cell cycle arrest through induced expression of p27Kip1 .
24849047	0	RAF	52,55	MEK	31,34	RAF	MEK	22882	5609	Gene	Gene	independently|nmod|START_ENTITY independently|compound|END_ENTITY	Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors .
20130576	0	RAF	0,3	RAF	31,34	RAF	RAF	22882	22882	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth .
20130576	0	RAF	31,34	RAF	0,3	RAF	RAF	22882	22882	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth .
26882073	0	RAF	19,22	RAF	50,53	RAF	RAF	22882	22882	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	Registered report : RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth .
26882073	0	RAF	50,53	RAF	19,22	RAF	RAF	22882	22882	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	Registered report : RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth .
11784866	0	RAF	45,48	RIN1	17,21	RAF	RIN1	22882	9610	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins .
26265449	0	RAF-1	0,5	ERK	98,101	RAF-1	ERK	5894	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|nmod|cells cells|acl|harboring harboring|nmod|activation activation|compound|END_ENTITY	RAF-1 promotes survival of thyroid_cancer cells harboring RET/PTC1 rearrangement independently of ERK activation .
8321321	0	RAF-1	33,38	Protein_kinase_C_alpha	0,22	RAF-1	Protein kinase C alpha	110157(Tax:10090)	18750(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Protein_kinase_C_alpha activates RAF-1 by direct phosphorylation .
8119890	0	RAF-1	88,93	prolactin	58,67	RAF-1	prolactin	24703(Tax:10116)	24683(Tax:10116)	Gene	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	Prolactin induces rapid phosphorylation and activation of prolactin receptor-associated RAF-1 kinase in a T-cell line .
24530606	0	RAF1	33,37	PHLPP	0,5	RAF1	PHLPP	110157(Tax:10090)	98432(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PHLPP is a negative regulator of RAF1 , which reduces colorectal_cancer cell motility and prevents tumor progression in mice .
26058013	0	RAF1	14,18	c-RAF	20,25	RAF1	c-RAF	5894	5894	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of RAF1 -LRB- c-RAF -RRB- by the Marine Alkaloid Lasonolide_A Induces Rapid Premature Chromosome Condensation .
10851022	0	RAFTK	26,31	PYK-2	20,25	RAFTK	PYK-2	2185	2185	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	The tyrosine kinase PYK-2 / RAFTK regulates natural killer -LRB- NK -RRB- cell cytotoxic response , and is translocated and activated upon specific target cell recognition and killing .
9402324	0	RAFTK	52,57	focal_adhesion_kinase	30,51	RAFTK	focal adhesion kinase	2185	5747	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the novel focal_adhesion_kinase RAFTK in hematopoietic cells .
2023940	0	RAG-1	120,125	RAG-2	126,131	RAG-1	RAG-2	19373(Tax:10090)	19374(Tax:10090)	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	A simple technique for generating probes for RNA in situ hybridization : an adjunct to genome mapping exemplified by the RAG-1 / RAG-2 gene cluster .
8445948	0	RAG-1	33,38	Recombination_activating_gene-1	0,31	RAG-1	Recombination activating gene-1	5896	5896	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Recombination_activating_gene-1 -LRB- RAG-1 -RRB- expression in all differentiation stages of B-lineage precursor acute_lymphoblastic_leukemia .
8934654	0	RAG-1	47,52	recombinase-activating_gene	18,45	RAG-1	recombinase-activating gene	19373(Tax:10090)	19373(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the recombinase-activating_gene -LRB- RAG-1 -RRB- in murine early embryogenesis .
1986864	0	RAG-1	37,42	recombination_activating_gene-1	4,35	RAG-1	recombination activating gene-1	19373(Tax:10090)	19373(Tax:10090)	Gene	Gene	transcript|compound|START_ENTITY transcript|amod|END_ENTITY	The recombination_activating_gene-1 -LRB- RAG-1 -RRB- transcript is present in the murine central nervous system .
10219001	0	RAG-1	51,56	recombination_activating_gene_1	18,49	RAG-1	recombination activating gene 1	19373(Tax:10090)	19373(Tax:10090)	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Activation of the recombination_activating_gene_1 -LRB- RAG-1 -RRB- transcript in bone marrow of senescent C57BL/6 mice by recombinant interleukin-7 .
9606993	0	RAG-2	47,52	CD3_epsilon	14,25	RAG-2	CD3 epsilon	5897	916	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD3_epsilon , CD3_zeta , and RAG-1 / RAG-2 in decidual CD56 + NK cells .
9606993	0	RAG-2	47,52	CD56	65,69	RAG-2	CD56	5897	4684	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of CD3_epsilon , CD3_zeta , and RAG-1 / RAG-2 in decidual CD56 + NK cells .
15094381	0	RAG-2	20,25	Myc-associated_zinc_finger_protein	38,72	RAG-2	Myc-associated zinc finger protein	19374(Tax:10090)	17188(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY Activation|nmod|promoter Activation|nmod|END_ENTITY	Activation of mouse RAG-2 promoter by Myc-associated_zinc_finger_protein .
2023940	0	RAG-2	126,131	RAG-1	120,125	RAG-2	RAG-1	19374(Tax:10090)	19373(Tax:10090)	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	A simple technique for generating probes for RNA in situ hybridization : an adjunct to genome mapping exemplified by the RAG-1 / RAG-2 gene cluster .
12044781	0	RAG-2	39,44	Sp1	57,60	RAG-2	Sp1	19374(Tax:10090)	20683(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors .
24037181	0	RAG1	29,33	CD40	0,4	RAG1	CD40	5896	958	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD40 interacts directly with RAG1 and RAG2 in autoaggressive T cells and Fas prevents CD40-induced RAG expression .
9697841	0	RAG1	107,111	RAG2	129,133	RAG1	RAG2	5896	5897	Gene	Gene	containing|dobj|START_ENTITY containing|nmod|END_ENTITY	V -LRB- D -RRB- J recombination signal recognition : distinct , overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2 .
22157821	0	RAG1	24,28	VprBP	0,5	RAG1	VprBP	19373(Tax:10090)	321006(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	VprBP binds full-length RAG1 and is required for B-cell development and V -LRB- D -RRB- J recombination fidelity .
9697841	0	RAG2	129,133	RAG1	107,111	RAG2	RAG1	5897	5896	Gene	Gene	containing|nmod|START_ENTITY containing|dobj|END_ENTITY	V -LRB- D -RRB- J recombination signal recognition : distinct , overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2 .
16051229	0	RAGE	90,94	Angiotensin_II	0,14	RAGE	Angiotensin II	81722(Tax:10116)	24179(Tax:10116)	Gene	Gene	overexpression|amod|START_ENTITY end|nmod|overexpression advanced|ccomp|end advanced|nsubj|augments augments|compound|END_ENTITY	Angiotensin_II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression .
19129693	0	RAGE	27,31	Angiotensin_II	0,14	RAGE	Angiotensin II	5891	183	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Angiotensin_II upregulates RAGE expression on podocytes : role of AT2 receptors .
25832424	0	RAGE	30,34	C-reactive_protein	0,18	RAGE	C-reactive protein	101669765	1401	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	C-reactive_protein stimulates RAGE expression in human coronary artery endothelial cells in vitro via ROS generation and ERK/NF-kB activation .
22386596	0	RAGE	0,4	C1q	11,14	RAGE	C1q	177	712	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	RAGE binds C1q and enhances C1q-mediated phagocytosis .
20847094	0	RAGE	107,111	EN-RAGE	120,127	RAGE	EN-RAGE	101669765	6283	Gene	Gene	ligand|amod|START_ENTITY ligand|appos|END_ENTITY	Effect of circulating soluble receptor for advanced glycation end products -LRB- sRAGE -RRB- and the proinflammatory RAGE ligand -LRB- EN-RAGE , S100A12 -RRB- on mortality in hemodialysis patients .
18390831	0	RAGE	0,4	Egr-1	67,72	RAGE	Egr-1	11596(Tax:10090)	13653(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	RAGE : developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells .
21099228	0	RAGE	36,40	Enpp1	44,49	RAGE	Enpp1	11596(Tax:10090)	18605(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Arterial_calcification is driven by RAGE in Enpp1 - / - mice .
21041074	0	RAGE	52,56	HMGB-1	20,26	RAGE	HMGB-1	177	3146	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|END_ENTITY	Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients .
15644117	0	RAGE	0,4	HMGB1	63,68	RAGE	HMGB1	26448(Tax:10090)	15289(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|activity activity|nmod|END_ENTITY	RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages .
16407300	0	RAGE	69,73	HMGB1	16,21	RAGE	HMGB1	11596(Tax:10090)	15289(Tax:10090)	Gene	Gene	pair|appos|START_ENTITY pair|compound|amphoterin amphoterin|appos|END_ENTITY	The amphoterin -LRB- HMGB1 -RRB- / receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- pair modulates myoblast proliferation , apoptosis , adhesiveness , migration , and invasiveness .
18264787	0	RAGE	108,112	HMGB1	161,166	RAGE	HMGB1	177	3146	Gene	Gene	receptor|appos|START_ENTITY Convergence|nmod|receptor Convergence|acl|signaling signaling|dobj|pathways pathways|nmod|B1 B1|appos|END_ENTITY	Convergence and amplification of toll-like receptor -LRB- TLR -RRB- and receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- signaling pathways via high mobility group B1 -LRB- HMGB1 -RRB- .
18302500	0	RAGE	74,78	HMGB1	0,5	RAGE	HMGB1	177	3146	Gene	Gene	dependent|nmod|START_ENTITY regulates|xcomp|dependent regulates|nsubj|END_ENTITY	HMGB1 regulates RANKL-induced osteoclastogenesis in a manner dependent on RAGE .
18331230	0	RAGE	0,4	HMGB1	22,27	RAGE	HMGB1	101669765	3146	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	RAGE as a receptor of HMGB1 -LRB- Amphoterin -RRB- : roles in health and disease .
19005067	0	RAGE	19,23	HMGB1	4,9	RAGE	HMGB1	11596(Tax:10090)	15289(Tax:10090)	Gene	Gene	mediates|advmod|START_ENTITY mediates|nsubj|receptor receptor|compound|END_ENTITY	The HMGB1 receptor RAGE mediates ischemic_brain_damage .
19876719	0	RAGE	49,53	HMGB1	18,23	RAGE	HMGB1	101669765	3146	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|protein protein|nummod|END_ENTITY	The expression of HMGB1 protein and its receptor RAGE in human malignant_tumors .
20100543	0	RAGE	108,112	HMGB1	84,89	RAGE	HMGB1	362787(Tax:10116)	25459(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY END_ENTITY|appos|receptors	Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1 , HMGB1 receptors -LRB- RAGE and TLR4 -RRB- , NF-kappaB expression .
20100543	0	RAGE	108,112	HMGB1	91,96	RAGE	HMGB1	362787(Tax:10116)	25459(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|nummod|END_ENTITY	Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1 , HMGB1 receptors -LRB- RAGE and TLR4 -RRB- , NF-kappaB expression .
20163887	0	RAGE	47,51	HMGB1	0,5	RAGE	HMGB1	177	3146	Gene	Gene	signaling|nmod|START_ENTITY factor-kB|acl|signaling activates|dobj|factor-kB activates|nsubj|END_ENTITY	HMGB1 activates nuclear factor-kB signaling by RAGE and increases the production of TNF-a in human umbilical vein endothelial cells .
21187488	0	RAGE	81,85	HMGB1	24,29	RAGE	HMGB1	101669765	3146	Gene	Gene	High-mobility_group_B1|appos|START_ENTITY High-mobility_group_B1|appos|END_ENTITY	High-mobility_group_B1 -LRB- HMGB1 -RRB- and receptor for advanced glycation end-products -LRB- RAGE -RRB- expression in canine lymphoma .
21494799	0	RAGE	67,71	HMGB1	0,5	RAGE	HMGB1	177	3146	Gene	Gene	pathways|compound|START_ENTITY monolayer|nmod|pathways permeability|nmod|monolayer increases|dobj|permeability increases|nsubj|END_ENTITY	HMGB1 increases permeability of the endothelial cell monolayer via RAGE and Src family tyrosine kinase pathways .
21990362	0	RAGE	134,138	HMGB1	64,69	RAGE	HMGB1	177	3146	Gene	Gene	products|appos|START_ENTITY receptor|nmod|products signaling|nmod|receptor END_ENTITY|acl|signaling	Heparan sulfate is essential for high mobility group protein 1 -LRB- HMGB1 -RRB- signaling by the receptor for advanced glycation end products -LRB- RAGE -RRB- .
22549347	0	RAGE	24,28	HMGB1	46,51	RAGE	HMGB1	177	3146	Gene	Gene	Relationship|nmod|START_ENTITY ligands|nsubj|Relationship ligands|dobj|END_ENTITY	Relationship of soluble RAGE and RAGE ligands HMGB1 and EN-RAGE to endothelial dysfunction in type 1 and type 2 diabetes_mellitus .
24073286	0	RAGE	70,74	HMGB1	8,13	RAGE	HMGB1	101669765	3146	Gene	Gene	receptor|amod|START_ENTITY stimulating|nmod|receptor adipokine|acl|stimulating adipokine|nsubj|END_ENTITY	Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line : contribution to chronic inflammation in fat tissue .
24474694	0	RAGE	98,102	HMGB1	39,44	RAGE	HMGB1	177	3146	Gene	Gene	receptor|amod|START_ENTITY reverses|nmod|receptor reverses|nsubj|peptide peptide|nmod|A-box A-box|nmod|protein protein|compound|END_ENTITY	An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor .
25652880	0	RAGE	75,79	HMGB1	19,24	RAGE	HMGB1	5891	3146	Gene	Gene	activation|amod|START_ENTITY survival|nmod|activation promotes|dobj|survival promotes|nsubj|release release|compound|END_ENTITY	Autophagy-mediated HMGB1 release promotes gastric_cancer cell survival via RAGE activation of extracellular_signal-regulated_kinases_1 / 2 .
25772690	0	RAGE	96,100	HMGB1	27,32	RAGE	HMGB1	177	3146	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	High motility group box 1 -LRB- HMGB1 -RRB- protein and its receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- expression in chronic rhinosinusitis without nasal_polyps .
25813710	0	RAGE	18,22	HMGB1	0,5	RAGE	HMGB1	81722(Tax:10116)	25459(Tax:10116)	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	HMGB1 may act via RAGE to promote angiogenesis in the later phase after intracerebral_hemorrhage .
26078977	0	RAGE	24,28	Insulin	34,41	RAGE	Insulin	101669765	3630	Gene	Gene	START_ENTITY|nmod|Resistance Resistance|compound|END_ENTITY	Relationship of Soluble RAGE with Insulin Resistance and Beta Cell Function during Development of Type_2_Diabetes_Mellitus .
23545311	0	RAGE	45,49	Receptor_for_advanced_glycation_end-product	0,43	RAGE	Receptor for advanced glycation end-product	177	177	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Receptor_for_advanced_glycation_end-product -LRB- RAGE -RRB- gene polymorphism 2245G/A is associated with pro-inflammatory , oxidative-glycation markers and sRAGE in diabetic_retinopathy .
20435311	0	RAGE	46,50	Receptor_for_advanced_glycation_end-products	0,44	RAGE	Receptor for advanced glycation end-products	11596(Tax:10090)	11596(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Receptor_for_advanced_glycation_end-products -LRB- RAGE -RRB- regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse .
23340902	0	RAGE	34,38	S100A9	55,61	RAGE	S100A9	101669765	6280	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of RAGE and its ligand -LRB- S100A9 -RRB- in cervical_lesions .
22025532	0	RAGE	130,134	S100B	143,148	RAGE	S100B	101669765	6285	Gene	Gene	ligand|amod|START_ENTITY ligand|appos|END_ENTITY	Human eosinophils express RAGE , produce RAGE ligands , exhibit PKC-delta phosphorylation and enhanced viability in response to the RAGE ligand , S100B .
17587138	0	RAGE	0,4	S100P	19,24	RAGE	S100P	101669765	6286	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	RAGE activation by S100P in colon_cancer stimulates growth , migration , and cell signaling pathways .
21829704	0	RAGE	63,67	TIRAP	0,5	RAGE	TIRAP	177	114609	Gene	Gene	transduces|nmod|START_ENTITY transduces|nsubj|END_ENTITY	TIRAP , an adaptor protein for TLR2/4 , transduces a signal from RAGE phosphorylated upon ligand binding .
17149374	0	RAGE	12,16	VEGF	45,49	RAGE	VEGF	101669765	7422	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|release release|amod|END_ENTITY	Mesothelial RAGE activation by AGEs enhances VEGF release and potentiates capillary tube formation .
15143181	0	RAGE	119,123	basic_fibroblast_growth_factor	74,104	RAGE	basic fibroblast growth factor	81722(Tax:10116)	54250(Tax:10116)	Gene	Gene	binding|compound|START_ENTITY END_ENTITY|nmod|binding	Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic_fibroblast_growth_factor and S100B via RAGE binding .
18922799	0	RAGE	19,23	diaphanous-1	48,60	RAGE	diaphanous-1	177	1729	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42 .
19164451	0	RAGE	81,85	receptor_for_advanced_glycation_end-products	35,79	RAGE	receptor for advanced glycation end-products	11596(Tax:10090)	177	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternative splicing of the murine receptor_for_advanced_glycation_end-products -LRB- RAGE -RRB- gene .
22116960	0	RAGE	74,78	receptor_for_advanced_glycation_end-products	28,72	RAGE	receptor for advanced glycation end-products	177	177	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	2245G/A polymorphism of the receptor_for_advanced_glycation_end-products -LRB- RAGE -RRB- gene is associated with diabetic_retinopathy in the Malaysian population .
20726326	0	RAGE	122,126	receptor_for_advanced_glycation_end_products	19,63	RAGE	receptor for advanced glycation end products	177	177	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of the receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- -374 _ T/A gene polymorphism and circulating soluble RAGE with nephropathy in type 1 diabetic patients .
20972729	0	RAGE	65,69	receptor_for_advanced_glycation_end_products	19,63	RAGE	receptor for advanced glycation end products	11596(Tax:10090)	11596(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of the receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- on bone metabolism under physiological and diabetic conditions .
22742537	0	RAGE	145,149	receptor_for_advanced_glycation_end_products	99,143	RAGE	receptor for advanced glycation end products	11596(Tax:10090)	11596(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Ligand-based design , synthesis , and biological evaluation of 2-aminopyrimidines , a novel series of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- inhibitors .
25718338	1	RAGE	64,68	receptor_for_advanced_glycation_end_products	18,62	RAGE	receptor for advanced glycation end products	177	177	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in intestinal fibrosis .
25888859	0	RAGE	54,58	receptor_for_advanced_glycation_end_products	8,52	RAGE	receptor for advanced glycation end products	177	177	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in liver_disease .
25888859	0	RAGE	54,58	receptor_for_advanced_glycation_end_products	8,52	RAGE	receptor for advanced glycation end products	177	177	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in liver_disease .
9299542	0	RAGE	96,100	receptor_for_advanced_glycation_end_products	50,94	RAGE	receptor for advanced glycation end products	177	177	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Type II alveolar epithelial cells in lung express receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- gene .
15843554	0	RAGs	14,18	CD5	103,106	RAGs	CD5	1946	921	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|expression expression|nmod|END_ENTITY	Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5 .
24863970	0	RAI1	37,41	GRIN2B	49,55	RAI1	GRIN2B	10743	2904	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Three rare_diseases in one Sib pair : RAI1 , PCK1 , GRIN2B mutations associated with Smith-Magenis_Syndrome , cytosolic_PEPCK_deficiency and NMDA receptor glutamate insensitivity .
24863970	0	RAI1	37,41	PCK1	43,47	RAI1	PCK1	10743	5105	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Three rare_diseases in one Sib pair : RAI1 , PCK1 , GRIN2B mutations associated with Smith-Magenis_Syndrome , cytosolic_PEPCK_deficiency and NMDA receptor glutamate insensitivity .
16729964	0	RAI14	67,72	NORPEG	59,65	RAI14	NORPEG	26064	26064	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Cell density-dependent nuclear/cytoplasmic localization of NORPEG -LRB- RAI14 -RRB- protein .
9106168	0	RALDH-2	106,113	retinaldehyde_dehydrogenase_type_2	70,104	RALDH-2	retinaldehyde dehydrogenase type 2	19378(Tax:10090)	19378(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Restricted expression and retinoic_acid-induced downregulation of the retinaldehyde_dehydrogenase_type_2 -LRB- RALDH-2 -RRB- gene during mouse development .
24788806	0	RALDH2	70,76	retinal_dehydrogenase_2	45,68	RALDH2	retinal dehydrogenase 2	19378(Tax:10090)	19378(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Retinoic_acid and GM-CSF coordinately induce retinal_dehydrogenase_2 -LRB- RALDH2 -RRB- expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells .
11983430	0	RALDH2	56,62	retinal_dehydrogenase_type-2	26,54	RALDH2	retinal dehydrogenase type-2	19378(Tax:10090)	19378(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Kinetic analysis of mouse retinal_dehydrogenase_type-2 -LRB- RALDH2 -RRB- for retinal substrates .
9499416	0	RAMP	161,165	fibroblast_growth_factor_receptor_1	104,139	RAMP	fibroblast growth factor receptor 1	25891	2260	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The t -LRB- 8 ; 13 -RRB- -LRB- p11 ; q11-12 -RRB- rearrangement associated with an atypical myeloproliferative_disorder fuses the fibroblast_growth_factor_receptor_1 gene to a novel gene RAMP .
12732346	0	RAMP2	69,74	adrenomedullin	11,25	RAMP2	adrenomedullin	58966(Tax:10116)	25026(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes of adrenomedullin and receptor_activity_modifying_protein_2 -LRB- RAMP2 -RRB- in myocardium and aorta in rats with isoproterenol-induced myocardial_ischemia .
26423127	0	RAMP3	54,59	Receptor_Activity-Modifying_Protein_3	15,52	RAMP3	Receptor Activity-Modifying Protein 3	56820(Tax:10116)	56820(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Receptor_Activity-Modifying_Protein_3 -LRB- RAMP3 -RRB- in the Vascular Actions of Adrenomedullin in Rat Mesenteric Artery Smooth Muscle Cells .
16075364	0	RAMP3	67,72	receptor_activity_modifying_protein-3	28,65	RAMP3	receptor activity modifying protein-3	56089(Tax:10090)	56089(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Parathyroid_hormone induces receptor_activity_modifying_protein-3 -LRB- RAMP3 -RRB- expression primarily via 3 ' ,5 ' - cyclic_adenosine_monophosphate signaling in osteoblasts .
19753112	0	RAN	75,78	MAD2B	37,42	RAN	MAD2B	5901	10459	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The mitotic_arrest_deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle .
24852074	0	RAN	27,30	Repeat_associated_non-ATG	0,25	RAN	Repeat associated non-ATG	5901	5901	Gene	Gene	translation|appos|START_ENTITY translation|amod|END_ENTITY	Repeat_associated_non-ATG -LRB- RAN -RRB- translation : new starts in microsatellite expansion disorders .
20503194	0	RANBP16	18,25	E12	102,105	RANBP16	E12	23039	26767	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12 .
12661011	0	RANBP2	44,50	Ran-binding_protein_2	21,42	RANBP2	Ran-binding protein 2	5903	5903	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fusion of ALK to the Ran-binding_protein_2 -LRB- RANBP2 -RRB- gene in inflammatory myofibroblastic_tumor .
21514280	0	RANK	16,20	HIF-1a	56,62	RANK	HIF-1a	8792	3091	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|advcl|activating activating|dobj|END_ENTITY	Hypoxia induces RANK and RANKL expression by activating HIF-1a in breast_cancer cells .
22210270	0	RANK	32,36	OPG	0,3	RANK	OPG	21934(Tax:10090)	18383(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	OPG inhibits gene expression of RANK and CAII in mouse osteoclast-like cell .
21748518	0	RANK	44,48	Osteoprotegerin	0,15	RANK	Osteoprotegerin	8792	4982	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- and related proteins -LRB- RANK , RANKL and TRAIL -RRB- in thyroid_disease .
19416721	0	RANK	22,26	RANKL	49,54	RANK	RANKL	8792	8600	Gene	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	The affinity of human RANK binding to its ligand RANKL .
21559440	0	RANK	29,33	Receptor_activator_of_NF-kB	0,27	RANK	Receptor activator of NF-kB	8792	8792	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Receptor_activator_of_NF-kB -LRB- RANK -RRB- expression in primary_tumors associates with bone metastasis occurrence in breast_cancer patients .
10601350	0	RANK	148,152	c-Fms	93,98	RANK	c-Fms	8792	1436	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor_activator_of_nuclear_factor_kappaB -LRB- RANK -RRB- receptors .
12244151	0	RANK	83,87	receptor_activator_of_NF-kappa_B	49,81	RANK	receptor activator of NF-kappa B	21934(Tax:10090)	21934(Tax:10090)	Gene	Gene	interactions|appos|START_ENTITY interactions|amod|END_ENTITY	Regulation of mucosal dendritic cell function by receptor_activator_of_NF-kappa_B -LRB- RANK -RRB- / RANK ligand interactions : impact on tolerance induction .
20857484	0	RANK	50,54	receptor_activator_of_NFkB	22,48	RANK	receptor activator of NFkB	8792	8792	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of receptor_activator_of_NFkB -LRB- RANK -RRB- in a series of primary solid_tumors and related bone metastases .
16443190	0	RANK	48,52	vascular_endothelial_growth_factor	10,44	RANK	vascular endothelial growth factor	8792	7422	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of vascular_endothelial_growth_factor on RANK gene expression in osteoclast precursors and on osteoclastogenesis .
15567162	0	RANK-L	0,6	NFATc1	33,39	RANK-L	NFATc1	21943(Tax:10090)	18018(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	RANK-L induces the expression of NFATc1 , but not of NFkappaB subunits during osteoclast formation .
15124262	0	RANK-L	22,28	Osteoprotegerin	0,15	RANK-L	Osteoprotegerin	8600	4982	Gene	Gene	system|amod|START_ENTITY END_ENTITY|dep|system	Osteoprotegerin -LRB- OPG -RRB- / RANK-L system in juvenile_idiopathic_arthritis : is there a potential modulating role for OPG/RANK-L in bone_injury ?
11870668	0	RANK-L	82,88	receptor_activator_of_nuclear_factor_kappa-B_ligand	29,80	RANK-L	receptor activator of nuclear factor kappa-B ligand	8600	8600	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of receptor_activator_of_nuclear_factor_kappa-B_ligand -LRB- RANK-L -RRB- in human osteolytic bone_tumors .
16995820	0	RANKL	23,28	Adiponectin	0,11	RANKL	Adiponectin	8600	9370	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway .
15940368	0	RANKL	22,27	Annexin_II	0,10	RANKL	Annexin II	8600	302	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Annexin_II stimulates RANKL expression through MAPK .
20053385	0	RANKL	109,114	CCR1	90,94	RANKL	CCR1	21943(Tax:10090)	12768(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	Evidences of the cooperative role of the chemokines CCL3 , CCL4 and CCL5 and its receptors CCR1 + and CCR5 + in RANKL + cell migration throughout experimental periodontitis in mice .
21453726	0	RANKL	17,22	CD4	37,40	RANKL	CD4	8600	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
16612568	0	RANKL	34,39	COX-2	44,49	RANKL	COX-2	8600	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Substance_P stimulates release of RANKL via COX-2 expression in human dental pulp cells .
26621504	0	RANKL	19,24	CXCL16	0,6	RANKL	CXCL16	8600	58191	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	CXCL16 upregulates RANKL expression in rheumatoid_arthritis synovial fibroblasts through the JAK2/STAT3 and p38/MAPK signaling pathway .
23142594	0	RANKL	0,5	CXCR6	33,38	RANKL	CXCR6	8600	10663	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	RANKL downregulates cell surface CXCR6 expression through JAK2/STAT3 signaling pathway during osteoclastogenesis .
25666350	0	RANKL	118,123	ERK	100,103	RANKL	ERK	21943(Tax:10090)	26413(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Obatoclax Regulates the Proliferation and Fusion of Osteoclast Precursors through the Inhibition of ERK Activation by RANKL .
24249810	0	RANKL	13,18	FGF2	0,4	RANKL	FGF2	8600	2247	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	FGF2 induces RANKL gene expression as well as IL1b regulated MHC class II in human bone marrow-derived mesenchymal progenitor stromal cells .
25656537	0	RANKL	26,31	FoxP3	83,88	RANKL	FoxP3	21943(Tax:10090)	20371(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Cells|nsubj|Effect Cells|nmod|END_ENTITY	A Bone Anabolic Effect of RANKL in a Murine Model of Osteoporosis Mediated Through FoxP3 -LRB- + -RRB- CD8 T Cells .
22387224	0	RANKL	92,97	Fyn	0,3	RANKL	Fyn	8600	2534	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Fyn positively regulates the activation of DAP12 and FcRy-mediated costimulatory signals by RANKL during osteoclastogenesis .
17032166	0	RANKL	73,78	IL-1beta	42,50	RANKL	IL-1beta	8600	3553	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	MKK3/6-p 38 MAPK signaling is required for IL-1beta and TNF-alpha-induced RANKL expression in bone marrow stromal cells .
25069739	0	RANKL	45,50	IL-3	20,24	RANKL	IL-3	8600	3562	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	In human basophils , IL-3 selectively induces RANKL expression that is modulated by IgER-dependent and IgER-independent stimuli .
27064449	0	RANKL	23,28	LGR4	0,4	RANKL	LGR4	21943(Tax:10090)	107515(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption .
16479591	0	RANKL	17,22	Leptin	0,6	RANKL	Leptin	21943(Tax:10090)	16846(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts .
17549607	0	RANKL	115,120	Macrophage_inflammatory_protein-1alpha	0,38	RANKL	Macrophage inflammatory protein-1alpha	21943(Tax:10090)	20302(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Macrophage_inflammatory_protein-1alpha -LRB- MIP-1alpha -RRB- enhances a receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways .
26053181	0	RANKL	70,75	MicroRNA-106b	0,13	RANKL	MicroRNA-106b	21943(Tax:10090)	723925(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-106b inhibits osteoclastogenesis and osteolysis by targeting RANKL in giant_cell_tumor_of_bone .
20357005	0	RANKL	18,23	Mitf	0,4	RANKL	Mitf	8600	4286	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Mitf induction by RANKL is critical for osteoclastogenesis .
16798863	0	RANKL	12,17	OPG	19,22	RANKL	OPG	8600	4982	Gene	Gene	Increase|nmod|START_ENTITY Increase|dep|ratio ratio|compound|END_ENTITY	Increase in RANKL : OPG ratio in synovia of patients with temporomandibular_joint_disorder .
16995820	0	RANKL	23,28	OPG	42,45	RANKL	OPG	8600	4982	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway .
20560139	0	RANKL	43,48	OPG	12,15	RANKL	OPG	8600	4982	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis .
18064667	0	RANKL	84,89	Osteoclast_stimulatory_transmembrane_protein	0,44	RANKL	Osteoclast stimulatory transmembrane protein	21943(Tax:10090)	74614(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Osteoclast_stimulatory_transmembrane_protein -LRB- OC-STAMP -RRB- , a novel protein induced by RANKL that promotes osteoclast differentiation .
11426018	0	RANKL	72,77	Osteoprotegerin	0,15	RANKL	Osteoprotegerin	8600	4982	Gene	Gene	regulate|nsubj|START_ENTITY ligand|ccomp|regulate ligand|nsubj|activator activator|compound|END_ENTITY	Osteoprotegerin and receptor activator of nuclear factor kappaB ligand -LRB- RANKL -RRB- regulate osteoclast formation by cells in the human rheumatoid_arthritic_joint .
12408468	0	RANKL	72,77	Osteoprotegerin	0,15	RANKL	Osteoprotegerin	8600	4982	Gene	Gene	ligand|dep|START_ENTITY ligand|nsubj|activator activator|compound|END_ENTITY	Osteoprotegerin and receptor activator of nuclear factor-kappaB ligand -LRB- RANKL -RRB- in the serum of healthy adults .
21748518	0	RANKL	50,55	Osteoprotegerin	0,15	RANKL	Osteoprotegerin	8600	4982	Gene	Gene	RANK|dep|START_ENTITY proteins|appos|RANK proteins|amod|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- and related proteins -LRB- RANK , RANKL and TRAIL -RRB- in thyroid_disease .
26629528	0	RANKL	87,92	Osteoprotegerin	0,15	RANKL	Osteoprotegerin	8600	4982	Gene	Gene	Ligand|appos|START_ENTITY Activator|nmod|Ligand Inhibitor|nmod|Activator END_ENTITY|appos|Inhibitor	Osteoprotegerin -LRB- OPG -RRB- , The Endogenous Inhibitor of Receptor Activator of NF-kB Ligand -LRB- RANKL -RRB- , is Dysregulated in BRCA Mutation Carriers .
26909278	0	RANKL	126,131	Osteoprotegerin	0,15	RANKL	Osteoprotegerin	8600	4982	Gene	Gene	inhibiting|dobj|START_ENTITY inhibits|advcl|inhibiting inhibits|nsubj|END_ENTITY	Osteoprotegerin inhibits bone resorption and prevents tumor development in a xenogenic model of Ewing 's _ sarcoma by inhibiting RANKL .
27028343	0	RANKL	17,22	Osteoprotegerin	0,15	RANKL	Osteoprotegerin	8600	4982	Gene	Gene	ADMA|appos|START_ENTITY ADMA|compound|END_ENTITY	Osteoprotegerin , RANKL , ADMA , and Fetuin-A serum levels in children with type_I_diabetes_mellitus .
11517184	0	RANKL	102,107	PTH	38,41	RANKL	PTH	8600	5741	Gene	Gene	stimulation|nmod|START_ENTITY associated|nmod|stimulation associated|nsubjpass|effects effects|nmod|END_ENTITY	Catabolic effects of continuous human PTH -LRB- 1 -- 38 -RRB- in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation .
14505343	0	RANKL	80,85	PTH	157,160	RANKL	PTH	117516(Tax:10116)	24694(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|bone bone|nmod|rats rats|acl|infused infused|nmod|END_ENTITY	In vivo administration of 1,25-dihydroxyvitamin _ D3 suppresses the expression of RANKL mRNA in bone of thyroparathyroidectomized rats constantly infused with PTH .
14969393	0	RANKL	43,48	PTH	0,3	RANKL	PTH	21943(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PTH differentially regulates expression of RANKL and OPG .
20697756	0	RANKL	29,34	PTH	0,3	RANKL	PTH	8600	5741	Gene	Gene	changes|nmod|START_ENTITY END_ENTITY|dep|changes	PTH -LRB- 1-34 -RRB- - induced changes in RANKL and OPG expression by human PDL cells modify osteoclast biology in a co-culture model with RAW 264.7 cells .
22102368	0	RANKL	16,21	PTHrP	0,5	RANKL	PTHrP	8600	5744	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	PTHrP increases RANKL expression by stromal cells from giant_cell_tumor_of_bone .
26553756	0	RANKL	95,100	Pannexin-1	0,10	RANKL	Pannexin-1	21943(Tax:10090)	55991(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Required|nmod|Production Required|nsubjpass|END_ENTITY	Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes .
24014651	0	RANKL	61,66	Progesterone_receptor	0,21	RANKL	Progesterone receptor	21943(Tax:10090)	18667(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Progesterone_receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells .
19416721	0	RANKL	49,54	RANK	22,26	RANKL	RANK	8600	8792	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|xcomp|binding	The affinity of human RANK binding to its ligand RANKL .
18182105	0	RANKL	12,17	RANKL	42,47	RANKL	RANKL	8600	8600	Gene	Gene	related|nsubjpass|START_ENTITY related|xcomp|END_ENTITY	Circulating RANKL is inversely related to RANKL mRNA levels in bone_in_osteoarthritic_males .
18182105	0	RANKL	42,47	RANKL	12,17	RANKL	RANKL	8600	8600	Gene	Gene	related|xcomp|START_ENTITY related|nsubjpass|END_ENTITY	Circulating RANKL is inversely related to RANKL mRNA levels in bone_in_osteoarthritic_males .
17667143	0	RANKL	112,117	RANK_ligand	99,110	RANKL	RANK ligand	8600	8600	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between osteoprotegerin -LRB- OPG -RRB- , receptor_activator_of_nuclear_factor-kappaB -LRB- RANK -RRB- , and RANK_ligand -LRB- RANKL -RRB- gene polymorphisms and circulating OPG , soluble RANKL levels , and bone_mineral_density in Korean postmenopausal women .
25678116	0	RANKL	96,101	Receptor_Activator_of_NF-kB_Ligand	60,94	RANKL	Receptor Activator of NF-kB Ligand	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Biotechnological approach for systemic delivery of membrane Receptor_Activator_of_NF-kB_Ligand -LRB- RANKL -RRB- active domain into the circulation .
20431232	0	RANKL	77,82	Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand	25,75	RANKL	Receptor Activator of Nuclear Factor-kappaB Ligand	8600	8600	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The relationship between Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand -LRB- RANKL -RRB- gene polymorphism and aortic_calcification in Korean women .
24524041	0	RANKL	120,125	Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand	68,118	RANKL	Receptor Activator of Nuclear Factor-kappaB Ligand	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	a-Tocopheryl_Succinate Inhibits Osteoclast Formation by Suppressing Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand -LRB- RANKL -RRB- Expression and Bone Resorption .
18645583	0	RANKL	40,45	Receptor_activator_of_NF-kappaB_Ligand	0,38	RANKL	Receptor activator of NF-kappaB Ligand	8600	8600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Receptor_activator_of_NF-kappaB_Ligand -LRB- RANKL -RRB- expression is associated with epithelial to mesenchymal transition in human prostate_cancer cells .
17195907	0	RANKL	52,57	Receptor_activator_of_nuclear_factor-kappaB_ligand	0,50	RANKL	Receptor activator of nuclear factor-kappaB ligand	8600	8600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- expression in hepatocellular_carcinoma with bone metastasis .
21189445	0	RANKL	53,58	Receptor_activator_of_nuclear_factor_kappa_B_ligand	0,51	RANKL	Receptor activator of nuclear factor kappa B ligand	8600	8600	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Receptor_activator_of_nuclear_factor_kappa_B_ligand -LRB- RANKL -RRB- levels in peri-implant crevicular fluid .
15474477	0	RANKL	66,71	Runx-2	0,6	RANKL	Runx-2	21943(Tax:10090)	12393(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY essential|nmod|expression essential|nsubj|END_ENTITY	Runx-2 is not essential for the vitamin_D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells .
26528796	0	RANKL	86,91	Src	106,109	RANKL	Src	21943(Tax:10090)	20779(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Myristoleic_acid inhibits osteoclast formation and bone resorption by suppressing the RANKL activation of Src and Pyk2 .
16612568	0	RANKL	34,39	Substance_P	0,11	RANKL	Substance P	8600	6863	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Substance_P stimulates release of RANKL via COX-2 expression in human dental pulp cells .
17467812	0	RANKL	86,91	TLR-2	96,101	RANKL	TLR-2	8600	7097	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation .
18786965	0	RANKL	98,103	TNF-alpha	117,126	RANKL	TNF-alpha	8600	7124	Gene	Gene	induction|amod|START_ENTITY involved|nmod|induction involved|nmod|END_ENTITY	IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17 .
26798197	0	RANKL	61,66	TNFa	39,43	RANKL	TNFa	117516(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Dietary zinc supplementation increased TNFa and IL1b-induced RANKL expression , resulting in a decrease in bone mineral density in rats .
11861538	0	RANKL	110,115	TNFalpha	0,8	RANKL	TNFalpha	117516(Tax:10116)	24835(Tax:10116)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	TNFalpha potently activates osteoclasts , through a direct action independent of and strongly synergistic with RANKL .
14751563	0	RANKL	79,84	Transforming_growth_factor-beta	0,31	RANKL	Transforming growth factor-beta	8600	7040	Gene	Gene	absence|nmod|START_ENTITY induces|nmod|absence induces|nsubj|END_ENTITY	Transforming_growth_factor-beta induces osteoclast formation in the absence of RANKL .
24102429	0	RANKL	33,38	Tumor_necrosis_factor-a	0,23	RANKL	Tumor necrosis factor-a	8600	7124	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Tumor_necrosis_factor-a enhances RANKL expression in gingival epithelial cells via protein kinase A signaling .
21777519	0	RANKL	59,64	Tumor_necrosis_factor-a_converting_enzyme	0,41	RANKL	Tumor necrosis factor-a converting enzyme	8600	6868	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Tumor_necrosis_factor-a_converting_enzyme -LRB- TACE -RRB- increases RANKL expression in osteoblasts and serves as a potential biomarker of periodontitis .
16294273	0	RANKL	112,117	beta-catenin	85,97	RANKL	beta-catenin	21943(Tax:10090)	12387(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Dominant negative N-cadherin inhibits osteoclast differentiation by interfering with beta-catenin regulation of RANKL , independent of cell-cell adhesion .
16328004	0	RANKL	0,5	bone_morphogenetic_protein-2	23,51	RANKL	bone morphogenetic protein-2	21943(Tax:10090)	12156(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	RANKL directly induces bone_morphogenetic_protein-2 expression in RANK-expressing POS-1 osteosarcoma cells .
25955862	0	RANKL	40,45	galectin-8	21,31	RANKL	galectin-8	8600	3964	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The mammalian lectin galectin-8 induces RANKL expression , osteoclastogenesis , and bone mass reduction in mice .
16613848	0	RANKL	0,5	inducible_nitric-oxide_synthase	17,48	RANKL	inducible nitric-oxide synthase	21943(Tax:10090)	18126(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	RANKL stimulates inducible_nitric-oxide_synthase expression and nitric_oxide production in developing osteoclasts .
14578201	0	RANKL	52,57	osteoprotegerin	59,74	RANKL	osteoprotegerin	8600	4982	Gene	Gene	Receptor_activator_of_nuclear_factor_kappaB_ligand|dep|START_ENTITY ratio|amod|Receptor_activator_of_nuclear_factor_kappaB_ligand ratio|compound|END_ENTITY	Receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- ratio is increased in severe osteolysis .
14675140	0	RANKL	151,156	osteoprotegerin	206,221	RANKL	osteoprotegerin	8600	4982	Gene	Gene	receptor_activator_of_nuclear_factor-kappaB_ligand|dep|START_ENTITY osteoclast_differentiation_factor|dep|receptor_activator_of_nuclear_factor-kappaB_ligand END_ENTITY|nsubj|osteoclast_differentiation_factor	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- , osteoclast_differentiation_factor -LRB- ODF -RRB- / receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- and osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- in ameloblastomas .
14678293	0	RANKL	68,73	osteoprotegerin	6,21	RANKL	osteoprotegerin	8600	4982	Gene	Gene	concentrations|appos|START_ENTITY kB|dobj|concentrations kB|nsubj|END_ENTITY	Serum osteoprotegerin and receptor activator of nuclear factors kB -LRB- RANKL -RRB- concentrations in normal children and in children with pubertal precocity , Turner 's _ syndrome and rheumatoid_arthritis .
15327520	0	RANKL	61,66	osteoprotegerin	69,84	RANKL	osteoprotegerin	8600	4982	Gene	Gene	receptor_activator_of_nuclear_factor-kappa_B_ligand|dep|START_ENTITY 1-alpha|amod|receptor_activator_of_nuclear_factor-kappa_B_ligand 1-alpha|amod|END_ENTITY	Role of receptor_activator_of_nuclear_factor-kappa_B_ligand -LRB- RANKL -RRB- , osteoprotegerin and macrophage protein 1-alpha -LRB- MIP-1a -RRB- in monoclonal_gammopathy_of_undetermined_significance -LRB- MGUS -RRB- .
15544627	0	RANKL	64,69	osteoprotegerin	113,128	RANKL	osteoprotegerin	8600	4982	Gene	Gene	receptor_activator_of_NF-kappaB_ligand|appos|START_ENTITY expression|nmod|receptor_activator_of_NF-kappaB_ligand END_ENTITY|nsubj|expression	Increased expression of receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- , its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn 's _ disease patients .
16736519	0	RANKL	44,49	osteoprotegerin	25,40	RANKL	osteoprotegerin	8600	4982	Gene	Gene	circulating|advcl|START_ENTITY circulating|dobj|END_ENTITY	The ratio of circulating osteoprotegerin to RANKL in early rheumatoid_arthritis predicts later_joint_destruction .
16828054	0	RANKL	178,183	osteoprotegerin	20,35	RANKL	osteoprotegerin	8600	4982	Gene	Gene	receptor_activator_of_nuclear_factor_kappaB_ligand|appos|START_ENTITY interactions|nmod|receptor_activator_of_nuclear_factor_kappaB_ligand role|nmod|interactions resonance|dep|role binding|nmod|resonance binding|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance : role in the interactions with receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- and RANK .
16912914	0	RANKL	15,20	osteoprotegerin	32,47	RANKL	osteoprotegerin	117516(Tax:10116)	25341(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effects of the RANKL inhibitor , osteoprotegerin , on the pain and histopathology of bone_cancer in rats .
17328075	0	RANKL	0,5	osteoprotegerin	6,21	RANKL	osteoprotegerin	8600	4982	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	RANKL : osteoprotegerin ratio and bone_mineral_density in children with untreated juvenile_dermatomyositis .
17453373	0	RANKL	115,120	osteoprotegerin	122,137	RANKL	osteoprotegerin	8600	4982	Gene	Gene	axis|appos|START_ENTITY axis|compound|END_ENTITY	Abnormal bone remodeling process is due to an imbalance in the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- axis in patients with solid tumors metastatic to the skeleton .
17530461	0	RANKL	0,5	osteoprotegerin	13,28	RANKL	osteoprotegerin	21943(Tax:10090)	18383(Tax:10090)	Gene	Gene	RANK|compound|START_ENTITY RANK|appos|END_ENTITY	RANKL , RANK , osteoprotegerin : key partners of osteoimmunology and vascular_diseases .
17608585	0	RANKL	0,5	osteoprotegerin	25,40	RANKL	osteoprotegerin	8600	4982	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|blocks blocks|compound|END_ENTITY	RANKL inhibition through osteoprotegerin blocks bone_loss in experimental periodontitis .
18025194	0	RANKL	11,16	osteoprotegerin	31,46	RANKL	osteoprotegerin	21943(Tax:10090)	18383(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Continuous RANKL inhibition in osteoprotegerin transgenic_mice and rats suppresses bone resorption without impairing lymphorganogenesis or functional immune responses .
18355453	0	RANKL	134,139	osteoprotegerin	30,45	RANKL	osteoprotegerin	8600	4982	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|levels levels|nmod|END_ENTITY	High levels of synovial fluid osteoprotegerin -LRB- OPG -RRB- and increased serum ratio of receptor activator of nuclear factor-kappa B ligand -LRB- RANKL -RRB- to OPG correlate with disease severity in patients with primary knee_osteoarthritis .
18433301	0	RANKL	0,5	osteoprotegerin	22,37	RANKL	osteoprotegerin	117516(Tax:10116)	25341(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats .
18584413	0	RANKL	186,191	osteoprotegerin	14,29	RANKL	osteoprotegerin	8600	4982	Gene	Gene	expression|amod|START_ENTITY ligand|nmod|expression ligand|nsubj|Expression Expression|nmod|activator activator|compound|END_ENTITY	Expression of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand -LRB- RANKL -RRB- in HCC70 breast_cancer cells and effects of treatment with gonadotropin-releasing_hormone on RANKL expression .
18584413	0	RANKL	86,91	osteoprotegerin	14,29	RANKL	osteoprotegerin	8600	4982	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|activator activator|compound|END_ENTITY	Expression of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand -LRB- RANKL -RRB- in HCC70 breast_cancer cells and effects of treatment with gonadotropin-releasing_hormone on RANKL expression .
19040304	0	RANKL	107,112	osteoprotegerin	116,131	RANKL	osteoprotegerin	117516(Tax:10116)	25341(Tax:10116)	Gene	Gene	increased|dobj|START_ENTITY increased|nmod|ratio ratio|amod|END_ENTITY	The HLA-B27 transgenic rat , a model of spondyloarthritis , has decreased bone mineral density and increased RANKL to osteoprotegerin mRNA ratio .
20003323	0	RANKL	0,5	osteoprotegerin	20,35	RANKL	osteoprotegerin	117516(Tax:10116)	25341(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	RANKL inhibition by osteoprotegerin prevents bone_loss without affecting local or systemic inflammation parameters in two rat arthritis models : comparison with anti-TNFalpha or anti-IL-1 therapies .
21870142	0	RANKL	87,92	osteoprotegerin	12,27	RANKL	osteoprotegerin	8600	4982	Gene	Gene	ligand|appos|START_ENTITY activator|nmod|ligand activator|dep|role role|nmod|END_ENTITY	The role of osteoprotegerin -LRB- OPG -RRB- receptor activator for nuclear factor kappaB ligand -LRB- RANKL -RRB- in cardiovascular pathology - a review .
22664871	0	RANKL	27,32	osteoprotegerin	67,82	RANKL	osteoprotegerin	8600	4982	Gene	Gene	structure|nmod|START_ENTITY complexed|nsubj|structure complexed|nmod|END_ENTITY	Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin .
23018352	0	RANKL	100,105	osteoprotegerin	22,37	RANKL	osteoprotegerin	8600	4982	Gene	Gene	levels|appos|START_ENTITY ligand|dobj|levels ligand|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation of plasma osteoprotegerin -LRB- OPG -RRB- and receptor activator of the nuclear factor kB ligand -LRB- RANKL -RRB- levels with clinical risk factors in patients with advanced carotid_atherosclerosis .
25138051	0	RANKL	106,111	osteoprotegerin	44,59	RANKL	osteoprotegerin	8600	4982	Gene	Gene	site|nmod|START_ENTITY interacting|nmod|site mimics|advcl|interacting mimics|dobj|END_ENTITY	Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL .
22190112	0	RANKL	10,15	parathyroid_hormone	28,47	RANKL	parathyroid hormone	21943(Tax:10090)	19226(Tax:10090)	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Sustained RANKL response to parathyroid_hormone in oncostatin_M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo .
20605949	0	RANKL	10,15	progesterone_receptor	149,170	RANKL	progesterone receptor	21943(Tax:10090)	18667(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|ordered ordered|xcomp|branching branching|nmod|absence absence|nmod|expression expression|compound|END_ENTITY	Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone_receptor expression .
22326262	0	RANKL	101,106	receptor_activator_of_NF-kB_ligand	65,99	RANKL	receptor activator of NF-kB ligand	8600	8600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- / S1P_receptor_1 signaling regulates receptor_activator_of_NF-kB_ligand -LRB- RANKL -RRB- expression in rheumatoid_arthritis .
11920576	0	RANKL	73,78	receptor_activator_of_NF-kappaB_ligand	33,71	RANKL	receptor activator of NF-kappaB ligand	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of activation-induced receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- expression in T cells .
15205949	0	RANKL	54,59	receptor_activator_of_NF-kappaB_ligand	14,52	RANKL	receptor activator of NF-kappaB ligand	8600	8600	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- mRNA in human multiple_myeloma cells .
23295770	0	RANKL	125,130	receptor_activator_of_NF-kappaB_ligand	85,123	RANKL	receptor activator of NF-kappaB ligand	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	proliferation|appos|START_ENTITY proliferation|amod|END_ENTITY	Atorvastatin-induced increase in progenitor cell levels is rather caused by enhanced receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- cell proliferation than by bone marrow mobilization .
10574572	0	RANKL	16,21	receptor_activator_of_NF_kappa_B_ligand	23,62	RANKL	receptor activator of NF kappa B ligand	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of RANKL -LRB- receptor_activator_of_NF_kappa_B_ligand -RRB- mRNA and protein in skeletal and extraskeletal tissues .
25776619	0	RANKL	95,100	receptor_activator_of_nuclear_factor-kappa-B_ligand	42,93	RANKL	receptor activator of nuclear factor-kappa-B ligand	8600	8600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CCAAT/enhancer-binding protein b promotes receptor_activator_of_nuclear_factor-kappa-B_ligand -LRB- RANKL -RRB- expression and osteoclast formation in the synovium in rheumatoid_arthritis .
25811130	0	RANKL	95,100	receptor_activator_of_nuclear_factor-kappa-B_ligand	42,93	RANKL	receptor activator of nuclear factor-kappa-B ligand	8600	8600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CCAAT/enhancer-binding protein b promotes receptor_activator_of_nuclear_factor-kappa-B_ligand -LRB- RANKL -RRB- expression and osteoclast formation in the synovium in rheumatoid_arthritis .
13679377	0	RANKL	75,80	receptor_activator_of_nuclear_factor-kappaB_ligand	23,73	RANKL	receptor activator of nuclear factor-kappaB ligand	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	Multimerization of the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- isoforms and regulation of osteoclastogenesis .
23360112	0	RANKL	54,59	receptor_activator_of_nuclear_factor_kB_ligand	6,52	RANKL	receptor activator of nuclear factor kB ligand	8600	8600	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum receptor_activator_of_nuclear_factor_kB_ligand -LRB- RANKL -RRB- levels predict biochemical recurrence in patients undergoing radical prostatectomy .
21708014	0	RANKL	119,124	receptor_activator_of_nuclear_factor_kappa-B_ligand	66,117	RANKL	receptor activator of nuclear factor kappa-B ligand	8600	8600	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Potential role and mechanism of IFN-gamma inducible protein-10 on receptor_activator_of_nuclear_factor_kappa-B_ligand -LRB- RANKL -RRB- expression in rheumatoid_arthritis .
17549607	0	RANKL	115,120	receptor_activator_of_nuclear_factor_kappaB_ligand	63,113	RANKL	receptor activator of nuclear factor kappaB ligand	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Macrophage_inflammatory_protein-1alpha -LRB- MIP-1alpha -RRB- enhances a receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways .
18072013	0	RANKL	68,73	receptor_activator_of_nuclear_factor_kappaB_ligand	16,66	RANKL	receptor activator of nuclear factor kappaB ligand	8600	8600	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- in healthy women and men .
16651437	0	RANK_ligand	168,179	MMP-9	180,185	RANK ligand	MMP-9	8600	4318	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB -LRB- RANK -RRB- / RANK_ligand / MMP-9 signaling in prostate_cancer .
17667143	0	RANK_ligand	99,110	RANKL	112,117	RANK ligand	RANKL	8600	8600	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between osteoprotegerin -LRB- OPG -RRB- , receptor_activator_of_nuclear_factor-kappaB -LRB- RANK -RRB- , and RANK_ligand -LRB- RANKL -RRB- gene polymorphisms and circulating OPG , soluble RANKL levels , and bone_mineral_density in Korean postmenopausal women .
16365894	0	RANK_ligand	0,11	heat_shock_factor-2	26,45	RANK ligand	heat shock factor-2	21943(Tax:10090)	15500(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	RANK_ligand expression in heat_shock_factor-2 deficient mouse bone marrow stromal/preosteoblast cells .
12555673	0	RANTES	0,6	CCL5	8,12	RANTES	CCL5	6352	6352	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	RANTES -LRB- CCL5 -RRB- production during primary respiratory_syncytial_virus_infection exacerbates airway_disease .
16628506	0	RANTES	43,49	CCL5	37,41	RANTES	CCL5	6352	6352	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	-LSB- Concentration of the beta-chemokine CCL5 -LRB- RANTES -RRB- in cerebrospinal fluid in patients with tick-borne_encephalitis -RSB- .
16873271	0	RANTES	14,20	CCL5	8,12	RANTES	CCL5	6352	6352	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of CCL5 -LRB- RANTES -RRB- in viral_lung_disease .
18956302	0	RANTES	28,34	CCL5	36,40	RANTES	CCL5	6352	6352	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and secretion of RANTES -LRB- CCL5 -RRB- in human adipocytes in response to immunological stimuli and hypoxia .
24468005	0	RANTES	29,35	CCL5	37,41	RANTES	CCL5	6352	6352	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and expression of RANTES -LRB- CCL5 -RRB- by human disc cells and modulation by IL-1-b and TNF-a in 3D culture .
26105364	1	RANTES	21,27	CCL5	29,33	RANTES	CCL5	6352	6352	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of RANTES -LRB- CCL5 -RRB- in maternal plasma , fetal plasma and placenta in pre-eclampsia and normotensive controls .
11108946	0	RANTES	56,62	CCR5	33,37	RANTES	CCR5	6352	1234	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of chemokine receptor CCR5 and production of RANTES and MIP-1alpha by interferon-beta .
18588983	0	RANTES	120,126	CCR5	70,74	RANTES	CCR5	6352	1234	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Large-scale expression and purification of the major HIV-1 coreceptor CCR5 and characterization of its interaction with RANTES .
19213338	0	RANTES	59,65	CCR5	79,83	RANTES	CCR5	6352	1234	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Regulatory effect of ligustrazine and Radix astragalus on RANTES and receptor CCR5 expression in the genesis and development process of endometriosis -RSB- .
8658171	0	RANTES	11,17	CC_CKR5	0,7	RANTES	CC CKR5	6352	1234	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	CC_CKR5 : a RANTES , MIP-1alpha , MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 .
10975998	0	RANTES	20,26	CD4	61,64	RANTES	CD4	6352	920	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Modulatory roles of RANTES in IL-4 production by human blood CD4 -LRB- + -RRB- T cells .
11314865	0	RANTES	28,34	CD4	61,64	RANTES	CD4	6352	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression and secretion of RANTES by human peripheral blood CD4 + cells are dependent on the presence of monocytes .
11343219	0	RANTES	0,6	CD4	23,26	RANTES	CD4	6352	920	Gene	Gene	production|compound|START_ENTITY production|nmod|+ +|compound|END_ENTITY	RANTES production from CD4 + lymphocytes correlates with host genotype and rates of human_immunodeficiency_virus_type_1 disease progression .
7525718	0	RANTES	139,145	CD4	26,29	RANTES	CD4	6352	920	Gene	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|Regulation Regulation|nmod|adhesion adhesion|nmod|T T|compound|END_ENTITY	Regulation of adhesion of CD4 + T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1_beta .
12714503	0	RANTES	0,6	CD44	36,40	RANTES	CD44	6352	960	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	RANTES -LRB- CCL5 -RRB- uses the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1_enhancement .
14975243	0	RANTES	25,31	CD8	6,9	RANTES	CD8	6352	925	Gene	Gene	store|dobj|START_ENTITY +|ccomp|store +|nsubj|END_ENTITY	Human CD8 + T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation .
10069998	0	RANTES	75,81	CFTR	67,71	RANTES	CFTR	6352	1080	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Chemokine expression in CF epithelia : implications for the role of CFTR in RANTES expression .
12509457	0	RANTES	31,37	CFTR	16,20	RANTES	CFTR	6352	1080	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif .
11480498	0	RANTES	167,173	ICAM-1	47,53	RANTES	ICAM-1	6352	3383	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	The role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- , and regulated on activation , normal T-cell expressed and secreted -LRB- RANTES -RRB- in the relationship between air pollution and asthma among children .
12165487	0	RANTES	51,57	IL-17	0,5	RANTES	IL-17	6352	3605	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts .
9527395	0	RANTES	61,67	IL-1alpha	22,31	RANTES	IL-1alpha	6352	3552	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Synergistic effect of IL-1alpha , IFN-gamma , and TNF-alpha on RANTES production by human renal tubular epithelial cells in vitro .
11385231	0	RANTES	25,31	IL-1beta	81,89	RANTES	IL-1beta	6352	3553	Gene	Gene	production|compound|START_ENTITY enhanced|nsubjpass|production enhanced|nmod|END_ENTITY	Interferon-gamma-induced RANTES production by human keratinocytes is enhanced by IL-1beta , TNF-alpha , IL-4 and IL-13 and is inhibited by dexamethasone and tacrolimus .
11600537	0	RANTES	22,28	IL-1beta	0,8	RANTES	IL-1beta	6352	3553	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	IL-1beta induction of RANTES -LRB- regulated upon activation , normal T cell expressed and secreted -RRB- chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappaB site in the proximal promoter .
11827101	0	RANTES	81,87	IL-1beta	144,152	RANTES	IL-1beta	6352	3553	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Cell surface phenotype and cytokine secretion in Caco-2 cell cultures : increased RANTES production and IL-2 transcription upon stimulation with IL-1beta .
8602829	0	RANTES	16,22	IL-1beta	31,39	RANTES	IL-1beta	6352	3553	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Inducibility of RANTES mRNA by IL-1beta in human bronchial epithelial cells is associated with increased NF-kappaB DNA binding activity .
10975998	0	RANTES	20,26	IL-4	30,34	RANTES	IL-4	6352	3565	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Modulatory roles of RANTES in IL-4 production by human blood CD4 -LRB- + -RRB- T cells .
8921438	0	RANTES	58,64	IL-4	23,27	RANTES	IL-4	6352	3565	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Contrasting effects of IL-4 , IL-10 and corticosteroids on RANTES production by human monocytes .
9644628	0	RANTES	50,56	IL-4	0,4	RANTES	IL-4	6352	3565	Gene	Gene	START_ENTITY|nsubj|augment augment|compound|END_ENTITY	IL-4 and IL-13 augment cytokine - and CD40-induced RANTES production by human renal tubular epithelial cells in vitro .
11970912	0	RANTES	45,51	Interferon-gamma	0,16	RANTES	Interferon-gamma	6352	3458	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Interferon-gamma enhances rhinovirus-induced RANTES secretion by airway epithelial cells .
16707500	0	RANTES	41,47	Interferon_regulatory_factor_8	0,30	RANTES	Interferon regulatory factor 8	6352	3394	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Interferon_regulatory_factor_8 regulates RANTES gene transcription in cooperation with interferon_regulatory_factor-1 , NF-kappaB , and PU .1 .
15482330	0	RANTES	28,34	Interleukin-1beta	0,17	RANTES	Interleukin-1beta	6352	3553	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Interleukin-1beta increases RANTES gene expression and production in synovial fibroblasts from human temporomandibular_joint .
17721998	0	RANTES	14,20	LMP1	68,72	RANTES	LMP1	6352	9260	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of RANTES and MCP-1 in epithelial cells is regulated via LMP1 and CD40 .
12605701	0	RANTES	17,23	MCP-1	79,84	RANTES	MCP-1	6352	6347	Gene	Gene	elevated|nsubj|START_ENTITY elevated|advcl|related related|nsubjpass|levels levels|compound|END_ENTITY	Monocyte-derived RANTES is intrinsically elevated in periodontal_disease while MCP-1 levels are related to inflammation and are inversely correlated with IL-12 levels .
15631778	0	RANTES	47,53	MCP-1	40,45	RANTES	MCP-1	6352	6347	Gene	Gene	expression|compound|START_ENTITY -RSB-|nsubj|expression -RSB-|advcl|-LSB- -LSB-|nmod|END_ENTITY	-LSB- The role of Cubilin in albumin-induced MCP-1 , RANTES expression by renal tubular epithelial cells -RSB- .
15848524	0	RANTES	77,83	MCP-1	70,75	RANTES	MCP-1	6352	6347	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|dep|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
22750227	0	RANTES	0,6	MCP-1	8,13	RANTES	MCP-1	6352	6347	Gene	Gene	START_ENTITY|appos|chemokines chemokines|compound|END_ENTITY	RANTES , MCP-1 chemokines and factors describing rheumatoid_arthritis .
12445801	0	RANTES	64,70	MIP-1beta	46,55	RANTES	MIP-1beta	6352	6351	Gene	Gene	MCP-1|dep|START_ENTITY MCP-1|dep|IP-10 IP-10|dep|END_ENTITY	The presence of chemokine -LRB- MCP-1 , MIP-1alpha , MIP-1beta , IP-10 , RANTES -RRB- - positive cells and chemokine_receptor -LRB- CCR5 , CXCR3 -RRB- - positive cells in inflamed human gingival tissues .
8658171	0	RANTES	11,17	MIP-1beta	31,40	RANTES	MIP-1beta	6352	6351	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	CC_CKR5 : a RANTES , MIP-1alpha , MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1 .
26944934	0	RANTES	37,43	PPAR-a	0,6	RANTES	PPAR-a	6352	5465	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	PPAR-a Agonist Fenofibrate Decreased RANTES Levels in Type 2 Diabetes Patients with Hypertriglyceridemia .
12243350	0	RANTES	41,47	TAK1	0,4	RANTES	TAK1	6352	6885	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TAK1 mediates lipopolysaccharide-induced RANTES promoter activation in BV-2 microglial cells .
15848524	0	RANTES	77,83	TGF-beta	36,44	RANTES	TGF-beta	6352	7040	Gene	Gene	TNF-alpha|dep|START_ENTITY TNF-alpha|compound|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
16564576	0	RANTES	77,83	TGF-beta1	34,43	RANTES	TGF-beta1	6352	7040	Gene	Gene	production|compound|START_ENTITY down-regulates|dobj|production down-regulates|nsubj|Transforming_growth_factor_beta_1 Transforming_growth_factor_beta_1|appos|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta1 -RRB- down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression .
21189258	0	RANTES	30,36	TGF-beta1	51,60	RANTES	TGF-beta1	6352	7040	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen_synthase_kinase-3beta-dependent beta-catenin signaling .
25211222	0	RANTES	69,75	TLR7	55,59	RANTES	TLR7	6352	51284	Gene	Gene	production|compound|START_ENTITY production|nummod|END_ENTITY	The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production .
10606930	0	RANTES	65,71	TNF_alpha	25,34	RANTES	TNF alpha	6352	7124	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	p38_MAP_kinase regulates TNF_alpha - , IL-1_alpha - and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells .
7505037	0	RANTES	61,67	TNF_alpha	0,9	RANTES	TNF alpha	20304(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNF_alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells .
25211222	0	RANTES	69,75	TRAM	34,38	RANTES	TRAM	6352	353376	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|END_ENTITY	The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production .
12663241	0	RANTES	48,54	Tumor_necrosis_factor_alpha	0,27	RANTES	Tumor necrosis factor alpha	6352	7124	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
11480498	0	RANTES	167,173	VCAM-1	91,97	RANTES	VCAM-1	6352	7412	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|amod|vascular_cell_adhesion_molecule-1 vascular_cell_adhesion_molecule-1|dep|END_ENTITY	The role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- , and regulated on activation , normal T-cell expressed and secreted -LRB- RANTES -RRB- in the relationship between air pollution and asthma among children .
12842758	0	RANTES	70,76	c-Jun_N-terminal_kinase	92,115	RANTES	c-Jun N-terminal kinase	20304(Tax:10090)	26419(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Ligation of IFN-gamma-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
17027916	0	RANTES	42,48	c-jun_N-terminal_kinase	116,139	RANTES	c-jun N-terminal kinase	6352	5599	Gene	Gene	START_ENTITY|acl|secretion secretion|nmod|inhibition inhibition|nmod|pathway pathway|amod|END_ENTITY	Isoproterenol suppresses cytokine-induced RANTES secretion in human lung epithelial cells through the inhibition of c-jun_N-terminal_kinase pathway .
10224471	0	RANTES	78,84	interferon-gamma	11,27	RANTES	interferon-gamma	6352	3458	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interferon-gamma on mobilization and release of eosinophil-derived RANTES .
10381494	0	RANTES	45,51	interferon-gamma	67,83	RANTES	interferon-gamma	6352	3458	Gene	Gene	stored|dobj|START_ENTITY stored|nmod|END_ENTITY	Rapid mobilization of intracellularly stored RANTES in response to interferon-gamma in human eosinophils .
9891032	0	RANTES	73,79	interferon_regulatory_factor_3	18,48	RANTES	interferon regulatory factor 3	6352	3661	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Essential role of interferon_regulatory_factor_3 in direct activation of RANTES chemokine transcription .
11028855	0	RANTES	31,37	nerve_growth_factor	8,27	RANTES	nerve growth factor	6352	4803	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of nerve_growth_factor in RANTES expression by keratinocytes .
9064347	0	RANTES	0,6	p125FAK	60,67	RANTES	p125FAK	20304(Tax:10090)	14083(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|nmod|END_ENTITY	RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells .
23935096	0	RANTES	62,68	p38	87,90	RANTES	p38	6352	1432	Gene	Gene	START_ENTITY|acl|induction induction|nmod|kinase kinase|amod|END_ENTITY	Sphingosine_kinase_1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kB activation .
10604552	0	RANTES	25,31	p38_MAP_kinase	0,14	RANTES	p38 MAP kinase	6352	1432	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	p38_MAP_kinase regulates RANTES production by TNF-alpha-stimulated human pulmonary vascular endothelial cells .
9469451	0	RANTES	0,6	phospholipase_D	21,36	RANTES	phospholipase D	6352	2822	Gene	Gene	activation|compound|START_ENTITY activation|nmod|cells cells|amod|END_ENTITY	RANTES activation of phospholipase_D in Jurkat T cells : requirement of GTP-binding proteins ARF and RhoA .
12176812	0	RANTES	31,37	protease_activated_receptor-1	51,80	RANTES	protease activated receptor-1	6352	2149	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Thrombin-induced expression of RANTES mRNA through protease_activated_receptor-1 in human synovial fibroblasts .
16249462	0	RANTES_receptor	95,110	CCR5	117,121	RANTES receptor	CCR5	1230	1234	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Risk of diabetic_nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES_receptor gene -LRB- CCR5 -RRB- : a sex-specific effect .
26013822	0	RAP	157,160	Receptor-Associated_Protein	128,155	RAP	Receptor-Associated Protein	4043	4043	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Generation of a potent Low_Density_Lipoprotein_Receptor-related_Protein_1 -LRB- LRP1 -RRB- antagonist by engineering a stable form of the Receptor-Associated_Protein -LRB- RAP -RRB- D3 domain .
15008249	0	RAP	108,111	Tg	148,150	RAP	Tg	116565(Tax:10116)	24826(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY associated|dobj|protein receptor|acl|associated transfected|nmod|receptor cells|acl|transfected secretion|nmod|cells thyroglobulin|acl|secretion thyroglobulin|dep|evidence evidence|nmod|role role|nmod|RAP RAP|nmod|pathway pathway|compound|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
15008249	0	RAP	108,111	Tg	24,26	RAP	Tg	116565(Tax:10116)	24826(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY associated|dobj|protein receptor|acl|associated transfected|nmod|receptor cells|acl|transfected secretion|nmod|cells thyroglobulin|acl|secretion thyroglobulin|appos|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
15008249	0	RAP	137,140	Tg	148,150	RAP	Tg	116565(Tax:10116)	24826(Tax:10116)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
15008249	0	RAP	137,140	Tg	24,26	RAP	Tg	116565(Tax:10116)	24826(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role thyroglobulin|dep|evidence thyroglobulin|appos|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
22617749	0	RAP	51,54	megalin	8,15	RAP	megalin	16976(Tax:10090)	14725(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo .
27094046	0	RAP	116,119	megalin	159,166	RAP	megalin	16976(Tax:10090)	14725(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY retention|nmod|protein due|nsubj|retention due|xcomp|END_ENTITY	Intracellular retention of thyroglobulin in the absence of the low-density lipoprotein receptor-associated protein -LRB- RAP -RRB- is likely due to premature binding to megalin in the biosynthetic pathway .
11579214	0	RAP	113,116	receptor-associated_protein	39,66	RAP	receptor-associated protein	116565(Tax:10116)	116565(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Binding of the low density lipoprotein receptor-associated_protein -LRB- RAP -RRB- to thyroglobulin -LRB- Tg -RRB- : putative role of RAP in the Tg secretory pathway .
12801688	0	RAP	44,47	receptor-associated_protein	15,42	RAP	receptor-associated protein	4043	4043	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Mapping of the receptor-associated_protein -LRB- RAP -RRB- binding proteins on living fibroblast cells using an atomic force microscope .
15383619	0	RAP	51,54	receptor-associated_protein	22,49	RAP	receptor-associated protein	16976(Tax:10090)	16976(Tax:10090)	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|END_ENTITY	Efficient transfer of receptor-associated_protein -LRB- RAP -RRB- across the blood-brain barrier .
15008249	0	RAP	137,140	thyroglobulin	9,22	RAP	thyroglobulin	116565(Tax:10116)	24826(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role END_ENTITY|dep|evidence	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
10454543	0	RAP30	32,37	SPT5	48,52	RAP30	SPT5	2963	6829	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Tat-SF1 protein associates with RAP30 and human SPT5 proteins .
22614839	0	RAP55	22,27	PRMT1	0,5	RAP55	PRMT1	26065	3276	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	PRMT1 is required for RAP55 to localize to processing bodies .
7590250	0	RAP74	30,35	TAFII250	6,14	RAP74	TAFII250	2962	6872	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human TAFII250 interacts with RAP74 : implications for RNA polymerase II initiation .
8625415	0	RAP74	89,94	TAFII250	0,8	RAP74	TAFII250	2962	6872	Gene	Gene	phosphorylates|dobj|START_ENTITY kinase|acl:relcl|phosphorylates kinase|nsubj|END_ENTITY	TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74 .
17525341	0	RAP80	0,5	BRCA1	14,19	RAP80	BRCA1	51720	672	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites .
17621610	0	RAP80	51,56	BRCA1	72,77	RAP80	BRCA1	51720	672	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response .
18270812	0	RAP80	42,47	BRCA1	18,23	RAP80	BRCA1	51720	672	Gene	Gene	genes|nummod|START_ENTITY interacting|dobj|genes Evaluation|acl|interacting Evaluation|nmod|END_ENTITY	Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast_cancer susceptibility .
21529986	0	RAP80	32,37	BRCA1	9,14	RAP80	BRCA1	51720	672	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Tubulin , BRCA1 , ERCC1 , Abraxas , RAP80 mRNA expression , p53/p21 immunohistochemistry and clinical outcome in patients with advanced non_small-cell_lung_cancer receiving first-line platinum-gemcitabine chemotherapy .
21529986	0	RAP80	32,37	ERCC1	16,21	RAP80	ERCC1	51720	2067	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Tubulin , BRCA1 , ERCC1 , Abraxas , RAP80 mRNA expression , p53/p21 immunohistochemistry and clinical outcome in patients with advanced non_small-cell_lung_cancer receiving first-line platinum-gemcitabine chemotherapy .
21857162	0	RAP80	76,81	MDC1	53,57	RAP80	MDC1	51720	9656	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Recruitment of proteins to DNA double-strand breaks : MDC1 directly recruits RAP80 .
17698038	0	RAP80	0,5	UBC9	49,53	RAP80	UBC9	51720	7329	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation .
24290981	0	RAPGEF2	96,103	IKKb	57,61	RAPGEF2	IKKb	9693	3551	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Control of epithelial cell migration and invasion by the IKKb - and CK1a-mediated degradation of RAPGEF2 .
8812503	0	RAPSN	57,62	rapsyn	31,37	RAPSN	rapsyn	5913	5913	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Cloning of cDNA encoding human rapsyn and mapping of the RAPSN gene locus to chromosome 11p11.2-p11 .1 .
15896339	0	RAR	46,49	CYP26A1	14,21	RAR	CYP26A1	5914	1592	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic_leukemia cells .
21110951	0	RAR	27,30	MED25	18,23	RAR	MED25	5914	81857	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	PTOV1 antagonizes MED25 in RAR transcriptional activation .
8734497	0	RAR	45,48	RAR_beta	115,123	RAR	RAR beta	19401(Tax:10090)	218772(Tax:10090)	Gene	Gene	beta|appos|START_ENTITY mutants|nmod|beta reveal|nsubj|mutants reveal|dobj|functions functions|nmod|isoforms isoforms|compound|END_ENTITY	Compound mutants for retinoic_acid receptor -LRB- RAR -RRB- beta and RAR_alpha_1 reveal developmental functions for multiple RAR_beta isoforms .
9426695	0	RAR	37,40	RAR_beta	14,22	RAR	RAR beta	5914	5915	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of RAR_beta expression by RAR - and RXR-selective retinoids in human lung_cancer cell lines : effect on growth inhibition and apoptosis induction .
10212874	0	RAR	40,43	RXR	46,49	RAR	RXR	10966	6256	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The independent and combined effects of RAR - , RXR - , and VDR-selective ligands on the growth of squamous_cell_carcinoma in vitro .
11877083	0	RAR	22,25	RXR	33,36	RAR	RXR	5914	6256	Gene	Gene	Effects|nmod|START_ENTITY or/and|nsubj|Effects or/and|dobj|retinoids retinoids|compound|END_ENTITY	-LSB- Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms -RSB- .
7779113	0	RAR	48,51	RXR	54,57	RAR	RXR	5914	6256	Gene	Gene	repressor|nmod|START_ENTITY repressor|amod|END_ENTITY	The orphan receptor TAK1 acts as a repressor of RAR - , RXR - and T3R-mediated signaling pathways .
7852380	0	RAR	35,38	RXR	61,64	RAR	RXR	5914	6256	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|retinoid_X_receptor retinoid_X_receptor|appos|END_ENTITY	Endogenous retinoic_acid receptor -LRB- RAR -RRB- - retinoid_X_receptor -LRB- RXR -RRB- heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes .
9491782	0	RAR	0,3	RXR	10,13	RAR	RXR	5914	6256	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	RAR - , not RXR , ligands inhibit cell activation and prevent apoptosis in B-lymphocytes .
9952315	0	RAR	45,48	RXR	109,112	RAR	RXR	5914	6256	Gene	Gene	synergism|appos|START_ENTITY agonists|nsubj|synergism agonists|nmod|agonists agonists|appos|END_ENTITY	Greater synergism of retinoic_acid_receptor -LRB- RAR -RRB- agonists with vitamin_D3 than that of retinoid_X_receptor -LRB- RXR -RRB- agonists with regard to growth inhibition and differentiation induction in monoblastic_leukemia cells .
10484292	0	RAR	12,15	hsRPB7	64,70	RAR	hsRPB7	5914	5436	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Ligand-free RAR can interact with the RNA polymerase II subunit hsRPB7 and repress transcription .
7852380	0	RAR	35,38	retinoid_X_receptor	40,59	RAR	retinoid X receptor	5914	6256	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|END_ENTITY	Endogenous retinoic_acid receptor -LRB- RAR -RRB- - retinoid_X_receptor -LRB- RXR -RRB- heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes .
7556459	0	RAR-beta	59,67	TGF-beta	0,8	RAR-beta	TGF-beta	218772(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	TGF-beta modulates the expression of retinoic_acid-induced RAR-beta in primary cultures of embryonic_palate cells .
12076325	0	RAR-beta	33,41	retinoic_acid_receptor-beta	4,31	RAR-beta	retinoic acid receptor-beta	5915	5915	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The retinoic_acid_receptor-beta -LRB- RAR-beta -RRB- mRNA expression in the oral_squamous_cell_carcinoma associated with betel quid use .
19786043	0	RAR-related_orphan_receptor_alpha	95,128	RORA	130,134	RAR-related orphan receptor alpha	RORA	6095	6095	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Convergence of linkage , gene expression and association data demonstrates the influence of the RAR-related_orphan_receptor_alpha -LRB- RORA -RRB- gene on neovascular AMD : a systems biology based approach .
25300573	0	RARA	53,57	retinoic_acid_receptor_alpha	23,51	RARA	retinoic acid receptor alpha	5914	5914	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of retinoic_acid_receptor_alpha -LRB- RARA -RRB- induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures .
21303978	0	RARRES1	17,24	AGBL2	69,74	RARRES1	AGBL2	5918	79841	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the a-tubulin tyrosination cycle .
20842219	0	RARRES1	17,24	EB1	52,55	RARRES1	EB1	5918	22919	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|END_ENTITY	Tumor Suppressor RARRES1 Regulates DLG2 , PP2A , VCP , EB1 , and Ankrd26 .
9667638	0	RAR_alpha	23,32	MDR1	41,45	RAR alpha	MDR1	5914	5243	Gene	Gene	gene|compound|START_ENTITY gene|nmod|expression expression|compound|END_ENTITY	Influence of exogenous RAR_alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines .
10192433	0	RAR_alpha	49,58	retinoic_acid_receptor_alpha	19,47	RAR alpha	retinoic acid receptor alpha	5914	5914	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alterations of the retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- gene in myeloid and lymphoid_malignancies .
9387294	0	RAR_alpha	118,127	retinoic_acid_receptor_alpha	88,116	RAR alpha	retinoic acid receptor alpha	5914	5914	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- Growth inhibitory effect of retinoic_acid in human breast_cancer cells correlates with retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- expression -RSB- .
8734497	0	RAR_beta	115,123	RAR	45,48	RAR beta	RAR	218772(Tax:10090)	19401(Tax:10090)	Gene	Gene	isoforms|compound|START_ENTITY functions|nmod|isoforms reveal|dobj|functions reveal|nsubj|mutants mutants|nmod|beta beta|appos|END_ENTITY	Compound mutants for retinoic_acid receptor -LRB- RAR -RRB- beta and RAR_alpha_1 reveal developmental functions for multiple RAR_beta isoforms .
9426695	0	RAR_beta	14,22	RAR	37,40	RAR beta	RAR	5915	5914	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of RAR_beta expression by RAR - and RXR-selective retinoids in human lung_cancer cell lines : effect on growth inhibition and apoptosis induction .
9511735	0	RAR_beta	61,69	retinoic_acid_receptor_beta	32,59	RAR beta	retinoic acid receptor beta	5915	5915	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of retinoic_acid_receptor_beta -LRB- RAR_beta -RRB- expression by phenylacetate in human neuroblastoma cells .
9822923	0	RAR_beta	59,67	retinoic_acid_receptor_beta	22,49	RAR beta	retinoic acid receptor beta	5915	5915	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Reduced expression of retinoic_acid_receptor_beta protein -LRB- RAR_beta -RRB- in human papillary_thyroid_carcinoma : immunohistochemical and western blot study .
24973045	0	RARa	46,50	Gck	18,21	RARa	Gck	24705(Tax:10116)	24385(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	A RARE of hepatic Gck promoter interacts with RARa , HNF4a and COUP-TFII that affect retinoic_acid - and insulin-induced Gck expression .
20413580	0	RARalpha	21,29	ADA3	6,10	RARalpha	ADA3	5914	10474	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket .
11682061	0	RARalpha	40,48	CRABPII	23,30	RARalpha	CRABPII	5914	1382	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The novel co-activator CRABPII binds to RARalpha and RXRalpha via two nuclear receptor interacting domains and does not require the AF-2 ` core ' .
15910691	0	RARalpha	13,21	MDR1	30,34	RARalpha	MDR1	5914	5243	Gene	Gene	gene|compound|START_ENTITY gene|nmod|expression expression|compound|END_ENTITY	Influence of RARalpha gene on MDR1 expression and P-glycoprotein function in human leukemic cells .
10933889	0	RARalpha	70,78	RARgamma	20,28	RARalpha	RARgamma	5914	5916	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Ser -LRB- 289 -RRB- in RARgamma and its homologous amino_acid residue of RARalpha and RARbeta in the binding of retinoic_acid .
11683493	0	RARalpha	63,71	RXR	77,80	RARalpha	RXR	5914	6256	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Retinoic_acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells .
17613435	0	RARalpha	37,45	RXR	15,18	RARalpha	RXR	5914	6256	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation .
17451432	0	RARalpha	66,74	p65	33,36	RARalpha	p65	5914	5970	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Involvement of NF-kappaB subunit p65 and retinoic_acid receptors , RARalpha and RXRalpha , in transcriptional regulation of the human GnRH_II gene .
10397747	0	RARalpha	58,66	retinoic_acid_receptor_alpha	28,56	RARalpha	retinoic acid receptor alpha	19401(Tax:10090)	19401(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of wild-type retinoic_acid_receptor_alpha -LRB- RARalpha -RRB- recapitulates retinoic_acid-sensitive transformation of primary myeloid progenitors by acute_promyelocytic_leukemia RARalpha-fusion genes .
16026464	0	RARbeta	0,7	DARPP-32	39,47	RARbeta	DARPP-32	24706(Tax:10116)	360616(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	RARbeta isoform-specific regulation of DARPP-32 gene expression : an ectopic expression study in the developing rat telencephalon .
9240560	0	RARbeta	41,48	retinoic_acid_receptor_beta	12,39	RARbeta	retinoic acid receptor beta	218772(Tax:10090)	218772(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the retinoic_acid_receptor_beta -LRB- RARbeta -RRB- during mouse development .
18715802	0	RARgamma	41,49	CD8	14,17	RARgamma	CD8	5916	925	Gene	Gene	T|nmod|START_ENTITY T|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CD8 -LRB- + -RRB- T cell functions by RARgamma .
10933889	0	RARgamma	20,28	RARalpha	70,78	RARgamma	RARalpha	5916	5914	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Ser -LRB- 289 -RRB- in RARgamma and its homologous amino_acid residue of RARalpha and RARbeta in the binding of retinoic_acid .
15234003	0	RARhoGAP	18,26	RhoGAP	45,51	RARhoGAP	RhoGAP	367085(Tax:10116)	58834(Tax:10116)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Identification of RARhoGAP , a novel putative RhoGAP gene expressed in male germ cells .
17028188	0	RAS/ERK	47,54	Oncostatin_M	0,12	RAS/ERK	Oncostatin M	26413(Tax:10090)	18413(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Oncostatin_M inhibits adipogenesis through the RAS/ERK and STAT5 signaling pathways .
3145192	0	RAS1	121,125	RAS2	91,95	RAS1	ras1	854268(Tax:4932)	854268(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Yeast mutants temperature-sensitive for growth after random mutagenesis of the chromosomal RAS2 gene and deletion of the RAS1 gene .
3145192	0	RAS2	91,95	RAS1	121,125	ras1	RAS1	854268(Tax:4932)	854268(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Yeast mutants temperature-sensitive for growth after random mutagenesis of the chromosomal RAS2 gene and deletion of the RAS1 gene .
24837431	0	RASA1	0,5	EPHB4	19,24	RASA1	EPHB4	5921	2050	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity .
24600991	0	RASA1	26,31	Hsa-mir-182	0,11	RASA1	Hsa-mir-182	5921	406958	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	Hsa-mir-182 downregulates RASA1 and suppresses lung_squamous_cell_carcinoma cell proliferation .
26126858	0	RASA1	61,66	MiR-182	18,25	RASA1	MiR-182	5921	406958	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular_carcinoma .
27101583	0	RASA1	93,98	MicroRNA-21	12,23	RASA1	MicroRNA-21	5921	406991	Gene	Gene	Involved|nmod|START_ENTITY Involved|nsubjpass|END_ENTITY	Circulating MicroRNA-21 Is Involved in Lymph Node Metastasis in Cervical_Cancer by Targeting RASA1 .
25384218	0	RASAL2	0,6	RAC1	17,21	RASAL2	RAC1	9462	5879	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	RASAL2 activates RAC1 to promote triple-negative_breast_cancer progression .
24029233	0	RASAL2	17,23	RasGAP	4,10	RASAL2	RasGAP	9462	5921	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The RasGAP gene , RASAL2 , is a tumor and metastasis suppressor .
25652366	0	RASAL3	0,6	RasGAP	30,36	RASAL3	RasGAP	320484(Tax:10090)	218397(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	RASAL3 , a novel hematopoietic RasGAP protein , regulates the number and functions of NKT cells .
14978793	0	RASGAP	57,63	RAS_GTPase-activating_protein	26,55	RASGAP	RAS GTPase-activating protein	5921	5921	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel RAS_GTPase-activating_protein -LRB- RASGAP -RRB- gene at 9q34 as an MLL fusion partner in a patient with de novo acute_myeloid_leukemia .
24958846	0	RASGRP2	24,31	CalDAG-GEFI	6,17	RASGRP2	CalDAG-GEFI	10235	10235	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human CalDAG-GEFI gene -LRB- RASGRP2 -RRB- mutation affects platelet function and causes severe bleeding .
16135822	0	RASSF1	23,29	RASSF1A	4,11	RASSF1	RASSF1A	56289(Tax:10090)	56289(Tax:10090)	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis .
17563743	0	RASSF1A	39,46	Aurora-A	15,23	RASSF1A	Aurora-A	11186	6790	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation .
17598981	0	RASSF1A	21,28	Cdc20	52,57	RASSF1A	Cdc20	11186	991	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The tumor suppressor RASSF1A does not interact with Cdc20 , an activator of the anaphase-promoting complex .
17099724	0	RASSF1A	37,44	Latent_membrane_protein_1	0,25	RASSF1A	Latent membrane protein 1	11186	9260	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Latent_membrane_protein_1 suppresses RASSF1A expression , disrupts microtubule structures and induces chromosomal_aberrations in human epithelial cells .
16135822	0	RASSF1A	4,11	RASSF1	23,29	RASSF1A	RASSF1	56289(Tax:10090)	56289(Tax:10090)	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis .
12670917	0	RASSF1A	68,75	RAS_association_domain_family_protein_1	27,66	RASSF1A	RAS association domain family protein 1	11186	11186	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Epigenetic inactivation of RAS_association_domain_family_protein_1 -LRB- RASSF1A -RRB- in malignant_cutaneous_melanoma .
12647816	0	RASSF1A	64,71	Ras-association_domain_family_1	31,62	RASSF1A	Ras-association domain family 1	11186	11186	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic inactivation of the Ras-association_domain_family_1 -LRB- RASSF1A -RRB- gene and its function in human carcinogenesis .
18182852	0	RASSF1A	58,65	Ras_association_domain_family_1A	24,56	RASSF1A	Ras association domain family 1A	11186	11186	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hypermethylation of the Ras_association_domain_family_1A -LRB- RASSF1A -RRB- gene in gallbladder_cancer .
26107164	0	RASSF1A	39,46	Tumor_Suppressor	16,32	RASSF1A	Tumor Suppressor	11186	7248	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Correction : The Tumor_Suppressor Gene , RASSF1A , Is Essential for Protection against Inflammation _ - Induced_Injury .
22266866	0	RASSF1A	0,7	estrogen_receptor_alpha	17,40	RASSF1A	estrogen receptor alpha	11186	2099	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	RASSF1A inhibits estrogen_receptor_alpha expression and estrogen-independent signalling : implications for breast_cancer development .
19181545	0	RASSF1A	141,148	p14	136,139	RASSF1A	p14	11186	1029	Gene	Gene	genes|nummod|START_ENTITY genes|dep|END_ENTITY	Increase sensitivity in detecting superficial , low grade bladder_cancer by combination analysis of hypermethylation of E-cadherin , p16 , p14 , RASSF1A genes in urine .
19181545	0	RASSF1A	141,148	p16	131,134	RASSF1A	p16	11186	1029	Gene	Gene	genes|nummod|START_ENTITY genes|dep|END_ENTITY	Increase sensitivity in detecting superficial , low grade bladder_cancer by combination analysis of hypermethylation of E-cadherin , p16 , p14 , RASSF1A genes in urine .
26482848	0	RASSF1A	130,137	protein_arginine_N-methyltransferase_5	18,56	RASSF1A	protein arginine N-methyltransferase 5	11186	10419	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of protein_arginine_N-methyltransferase_5 -LRB- PRMT5 -RRB- as a novel interacting protein with the tumor suppressor protein RASSF1A .
19962960	0	RASSF2	29,35	MST1	53,57	RASSF2	MST1	9770	4485	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity .
21278800	0	RASSF7	0,6	JNK	42,45	RASSF7	JNK	8045	5599	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7 .
25725070	0	RASSF8	31,37	MAGI	11,15	RASSF8	MAGI	43096(Tax:7227)	37403(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye .
14978793	0	RAS_GTPase-activating_protein	26,55	RASGAP	57,63	RAS GTPase-activating protein	RASGAP	5921	5921	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel RAS_GTPase-activating_protein -LRB- RASGAP -RRB- gene at 9q34 as an MLL fusion partner in a patient with de novo acute_myeloid_leukemia .
12670917	0	RAS_association_domain_family_protein_1	27,66	RASSF1A	68,75	RAS association domain family protein 1	RASSF1A	11186	11186	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Epigenetic inactivation of RAS_association_domain_family_protein_1 -LRB- RASSF1A -RRB- in malignant_cutaneous_melanoma .
15299031	0	RAX	29,32	PKR	69,72	RAX	PKR	30062	5610	Gene	Gene	phosphorylation|nmod|START_ENTITY required|nsubjpass|phosphorylation required|nmod|activation activation|compound|END_ENTITY	Serine 18 phosphorylation of RAX , the PKR activator , is required for PKR activation and consequent translation inhibition .
8528059	0	RB-1	25,29	retinoblastoma	4,18	RB-1	retinoblastoma	5925	5925	Gene	Gene	status|appos|START_ENTITY status|compound|END_ENTITY	The retinoblastoma gene -LRB- RB-1 -RRB- status in multiple_myeloma : a report on 35 cases .
27036041	0	RB1	103,106	miR-590	0,7	RB1	miR-590	5925	693175	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	miR-590 promotes cell proliferation and invasion in T-cell_acute_lymphoblastic_leukaemia by inhibiting RB1 .
15881662	0	RB1	36,39	pRb	78,81	RB1	pRb	5925	5925	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	Altered structure and expression of RB1 gene and increased phosphorylation of pRb in human vestibular_schwannomas .
14660307	0	RB1	47,50	retinoblastoma	26,40	RB1	retinoblastoma	5925	5925	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Methylation status of the retinoblastoma gene -LRB- RB1 -RRB- in osteosarcoma : no evidence for hypermethylation .
8031579	0	RB1	49,52	retinoblastoma_1	26,42	RB1	retinoblastoma 1	19645(Tax:10090)	19645(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal assignment of retinoblastoma_1 gene -LRB- RB1 -RRB- to mouse 14D3 and rat 15q12 by fluorescence in situ hybridization .
11118038	0	RB18A	0,5	p53	76,79	RB18A	p53	5469	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	RB18A , whose gene is localized on chromosome 17q12-q21 .1 , regulates in vivo p53 transactivating activity .
15848166	0	RB18A	0,5	p53	36,39	RB18A	p53	5469	7157	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|protein protein|compound|END_ENTITY	RB18A enhances expression of mutant p53 protein in human cells .
9444950	0	RB18A	18,23	p53	116,119	RB18A	p53	5469	7157	Gene	Gene	Identification|nmod|START_ENTITY Identification|appos|protein protein|acl:relcl|shares shares|dobj|properties properties|nmod|END_ENTITY	Identification of RB18A , a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53 .
9444950	0	RB18A	18,23	p53	39,42	RB18A	p53	5469	7157	Gene	Gene	Identification|nmod|START_ENTITY Identification|appos|protein protein|compound|END_ENTITY	Identification of RB18A , a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53 .
17706618	0	RB1CC1	0,6	mTOR	53,57	RB1CC1	mTOR	12421(Tax:10090)	21977(Tax:10090)	Gene	Gene	causes|nsubj|START_ENTITY causes|nmod|END_ENTITY	RB1CC1 insufficiency causes neuronal_atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer 's _ diseases .
10760507	0	RB2	73,76	p130	78,82	RB2	p130	19651(Tax:10090)	19651(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A CDE/CHR-like element mediates repression of transcription of the mouse RB2 -LRB- p130 -RRB- gene .
16873370	0	RBBP1	87,92	retinoblastoma-binding_protein_1	53,85	RBBP1	retinoblastoma-binding protein 1	5926	5926	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Estrogen receptor isoform-specific regulation of the retinoblastoma-binding_protein_1 -LRB- RBBP1 -RRB- gene : roles of AF1 and enhancer elements .
18851979	0	RBBP6	0,5	YB-1	139,143	RBBP6	YB-1	5930	4904	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain , leading to ubiquitination and proteosomal degradation of YB-1 .
21676486	0	RBBP6	61,66	retinoblastoma_binding_protein_6	27,59	RBBP6	retinoblastoma binding protein 6	5930	5930	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of retinoblastoma_binding_protein_6 -LRB- RBBP6 -RRB- in human lung_cancer .
23912458	0	RBCK1	18,23	FKBPL	48,53	RBCK1	FKBPL	10616	63943	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Identification of RBCK1 as a novel regulator of FKBPL : implications for tumor growth and response to tamoxifen .
11880344	0	RBF	12,15	Cdk4	96,100	RBF	Cdk4	43231(Tax:7227)	36854(Tax:7227)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin_D / Cdk4 induced cellular growth .
18367646	0	RBF1	0,4	dCAP-D3	99,106	RBF1	dCAP-D3	31027(Tax:7227)	33778(Tax:7227)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|interaction interaction|nmod|END_ENTITY	RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3 .
25211016	0	RBFOX1	0,6	MBNL1	23,28	RBFOX1	MBNL1	268859(Tax:10090)	56758(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	RBFOX1 cooperates with MBNL1 to control splicing in muscle , including events altered in myotonic_dystrophy type 1 .
21106733	0	RBM15	91,96	ORF57	40,45	RBM15	ORF57	64783	4961525(Tax:37296)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59 .
24375645	0	RBM24	20,25	p63	36,39	RBM24	p63	221662	8626	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RNA-binding protein RBM24 regulates p63 expression via mRNA stability .
18663000	0	RBM25	22,27	Bcl-x	38,43	RBM25	Bcl-x	58517	598	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5 ' splice site selection .
25544695	0	RBM3	59,63	RNA_binding_motif_protein_3	30,57	RBM3	RNA binding motif protein 3	102176209	102176209	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization of RNA_binding_motif_protein_3 -LRB- RBM3 -RRB- gene from Pashmina goat .
22798430	0	RBM38	0,5	E2F1	44,48	RBM38	E2F1	55544	1869	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	RBM38 is a direct transcriptional target of E2F1 that limits E2F1-induced proliferation .
21518792	0	RBM4	0,4	PTB	20,23	RBM4	PTB	5936	5725	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	RBM4 down-regulates PTB and antagonizes its activity in muscle cell-specific alternative splicing .
16934801	0	RBM4	40,44	WT1	0,3	RBM4	WT1	5936	7490	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo .
22569250	0	RBM5	17,21	DHX15	69,74	RBM5	DHX15	10181	1665	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activity .
21327109	0	RBMX	29,33	hnRNP_G	21,28	RBMX	hnRNP G	27316	27316	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Novel domains in the hnRNP_G / RBMX protein with distinct roles in RNA binding and targeting nascent transcripts .
10749975	0	RBMY	0,4	Tra2beta	88,96	RBMY	Tra2beta	5940	6434	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	RBMY , a probable human spermatogenesis factor , and other hnRNP_G proteins interact with Tra2beta and affect splicing .
26185016	0	RBMY	0,4	glycogen_synthase_kinase_3b	27,54	RBMY	glycogen synthase kinase 3b	5940	2932	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	RBMY , a novel inhibitor of glycogen_synthase_kinase_3b , increases tumor stemness and predicts poor prognosis of hepatocellular_carcinoma .
8972179	0	RBP	40,43	interleukin-6	61,74	RBP	interleukin-6	57794	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The mammalian transcriptional repressor RBP -LRB- CBF1 -RRB- regulates interleukin-6 gene expression .
7010968	0	RBP	42,45	retinol-binding_protein	17,40	RBP	retinol-binding protein	5950	5950	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	-LSB- Localization of retinol-binding_protein -LRB- RBP -RRB- in ocular tissues .
18777500	0	RBP-4	27,32	Retinol-binding_protein_4	0,25	RBP-4	Retinol-binding protein 4	5950	5950	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Retinol-binding_protein_4 -LRB- RBP-4 -RRB- levels do not change after oral glucose tolerance test and after dexamethasone , but correlate with some indices of insulin resistance in humans .
10066785	0	RBP-J	42,47	MyoD	57,61	RBP-J	MyoD	19664(Tax:10090)	17927(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis .
11239004	0	RBP-J	33,38	Notch1	76,82	RBP-J	Notch1	19664(Tax:10090)	18128(Tax:10090)	Gene	Gene	interact|amod|START_ENTITY regions|nmod|interact repeats|nsubj|regions repeats|nmod|RAMIC RAMIC|compound|END_ENTITY	The N - and C-terminal regions of RBP-J interact with the ankyrin repeats of Notch1 RAMIC to activate transcription .
9374409	0	RBP-J	15,20	Notch1	54,60	RBP-J	Notch1	19664(Tax:10090)	18128(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives .
10502683	0	RBP-J	57,62	RBP-L	48,53	RBP-J	RBP-L	19664(Tax:10090)	19668(Tax:10090)	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	Studies on the cell-type specific expression of RBP-L , a RBP-J family member , by replacement insertion of beta-galactosidase .
15194757	0	RBP-J	0,5	RTA	137,140	RBP-J	RTA	3516	4961526(Tax:37296)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	RBP-J -LRB- CSL -RRB- is essential for activation of the K14/vGPCR promoter of Kaposi 's _ sarcoma-associated_herpesvirus by the lytic switch protein RTA .
1429518	0	RBP-J_kappa	75,86	DNA_binding_protein	54,73	RBP-J kappa	DNA binding protein	19664(Tax:10090)	26386(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biochemical and immunological characterization of the DNA_binding_protein -LRB- RBP-J_kappa -RRB- to mouse J kappa recombination signal sequence .
15247148	0	RBP-Jk	116,122	CBF-1	110,115	RBP-Jk	CBF-1	3516	3516	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Notch 1 and 3 receptor signaling modulates vascular smooth_muscle_cell growth , apoptosis , and migration via a CBF-1 / RBP-Jk dependent pathway .
11601899	0	RBP-Jk	95,101	CBP/p300	57,65	RBP-Jk	CBP/p300	3516	1387;2033	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Intranuclear localization of the transcription coadaptor CBP/p300 and the transcription factor RBP-Jk in relation to EBNA-2 and -5 in B lymphocytes .
20508646	0	RBP-Jk	16,22	JIP1	0,4	RBP-Jk	JIP1	3516	9479	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	JIP1 binding to RBP-Jk mediates cross-talk between the Notch1 and JIP1-JNK signaling pathway .
10502683	0	RBP-L	48,53	RBP-J	57,62	RBP-L	RBP-J	19668(Tax:10090)	19664(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	Studies on the cell-type specific expression of RBP-L , a RBP-J family member , by replacement insertion of beta-galactosidase .
8325883	0	RBP1	29,33	RNA-binding_protein	3,22	RBP1	RNA-binding protein	855587(Tax:4932)	855587(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An RNA-binding_protein gene -LRB- RBP1 -RRB- of Saccharomyces_cerevisiae encodes a putative glucose-repressible protein containing two RNA recognition motifs .
25015565	0	RBP2	20,24	CagA	56,60	RBP2	CagA	5948	6279	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells .
25974964	0	RBP2	20,24	TGF-b1	82,88	RBP2	TGF-b1	5948	7040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Histone demethylase RBP2 promotes malignant progression of gastric_cancer through TGF-b1 - -LRB- p-Smad3 -RRB- - RBP2-E-cadherin-Smad3 feedback circuit .
21766603	0	RBP4	11,15	Chemerin	1,9	RBP4	Chemerin	5950	5919	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Chemerin , RBP4 and vaspin -RSB- .
21766603	0	RBP4	11,15	Chemerin	1,9	RBP4	Chemerin	5950	5919	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- Chemerin , RBP4 and vaspin -RSB- .
19816414	0	RBP4	27,31	Retinol-binding_protein_4	0,25	RBP4	Retinol-binding protein 4	5950	5950	Gene	Gene	increased|dep|START_ENTITY increased|nsubjpass|END_ENTITY	Retinol-binding_protein_4 -LRB- RBP4 -RRB- protein expression is increased in omental adipose tissue of severely obese patients .
18324929	0	RBP4	27,31	aP2	51,54	RBP4	aP2	5950	2167	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	High circulating levels of RBP4 and mRNA levels of aP2 , PGC-1alpha and UCP-2 predict improvement_in_insulin_sensitivity following pioglitazone treatment of drug-na ve type 2 diabetic subjects .
24994759	0	RBP4	23,27	insulin	33,40	RBP4	insulin	5950	3630	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|resistance resistance|compound|END_ENTITY	Association of urinary RBP4 with insulin resistance , inflammation , and microalbuminuria .
21538175	0	RBP4	245,249	protein_tyrosine_phosphatase_1B	174,205	RBP4	protein tyrosine phosphatase 1B	19662(Tax:10090)	19246(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Susceptibility to diet-induced obesity and glucose_intolerance in the APP -LRB- SWE -RRB- / PSEN1 -LRB- A246E -RRB- mouse model of Alzheimer 's _ disease is associated with increased brain levels of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- and retinol-binding_protein_4 -LRB- RBP4 -RRB- , and basal phosphorylation of S6 ribosomal protein .
20544399	0	RBP4	42,46	retinol-binding_protein-4	15,40	RBP4	retinol-binding protein-4	5950	5950	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of retinol-binding_protein-4 -LRB- RBP4 -RRB- with lipid parameters in obese women .
23584360	0	RBP4	34,38	retinol-binding_protein_4	7,32	RBP4	retinol-binding protein 4	5950	5950	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Plasma retinol-binding_protein_4 -LRB- RBP4 -RRB- levels and risk of coronary_heart_disease : a prospective analysis among women in the nurses ' health study .
23707795	0	RBP4	89,93	retinol-binding_protein_4	62,87	RBP4	retinol-binding protein 4	396166(Tax:9031)	396166(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ontogenic expression pattern and genetic polymorphisms of the retinol-binding_protein_4 -LRB- RBP4 -RRB- gene in Erlang mountainous chickens .
26619134	0	RBP4	127,131	retinol_binding_protein_4	100,125	RBP4	retinol binding protein 4	19662(Tax:10090)	19662(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Male mice are susceptible to high fat diet-induced hyperglycaemia and display increased circulatory retinol_binding_protein_4 -LRB- RBP4 -RRB- levels and its expression in visceral adipose depots .
9162037	0	RBPJkappa	37,46	ERBB-2	18,24	RBPJkappa	ERBB-2	3516	2064	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH .
21643017	0	RBSP3	65,70	MiR-100	0,7	RBSP3	MiR-100	10217	406892	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-100 regulates cell differentiation and survival by targeting RBSP3 , a phosphatase-like tumor suppressor in acute myeloid_leukemia .
24292229	0	RBX1	41,45	RING_box_protein-1	21,39	RBX1	RING box protein-1	9978	9978	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Prognostic impact of RING_box_protein-1 -LRB- RBX1 -RRB- expression in gastric_cancer .
14664718	0	RBaK	62,66	androgen_receptor	86,103	RBaK	androgen receptor	57786	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen_receptor and enhances its transcriptional activity .
7730337	0	RC3	106,109	neurogranin	93,104	RC3	neurogranin	64356(Tax:10116)	64356(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Structure and regulation of the gene encoding the neuron-specific protein_kinase_C substrate neurogranin -LRB- RC3 protein -RRB- .
7898318	0	RC3	16,19	neurogranin	21,32	RC3	neurogranin	64356(Tax:10116)	64356(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of RC3 -LRB- neurogranin -RRB- in rat brain subcellular fractions .
8080473	0	RC3	58,61	neurogranin	71,82	RC3	neurogranin	64356(Tax:10116)	64356(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Characterization of a 7.5-kDa protein_kinase_C substrate -LRB- RC3 protein , neurogranin -RRB- from rat brain .
26170170	0	RC3H1	0,5	A20	39,42	RC3H1	A20	149041	28935	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|mRNA mRNA|compound|END_ENTITY	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-kB pathway .
23150431	0	RCAN1	46,51	Bcl-2	14,19	RCAN1	Bcl-2	1827	596	Gene	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|expression expression|compound|END_ENTITY	CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen_peroxide-induced neuronal_death .
18485347	0	RCAN1	23,28	DSCR1	16,21	RCAN1	DSCR1	54720(Tax:10090)	54720(Tax:10090)	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of DSCR1 -LRB- RCAN1 or Adapt78 -RRB- in the peri-infarct cortex after experimental stroke .
25546086	0	RCAN1	60,65	Ubiquitin-specific_Protease_22	0,30	RCAN1	Ubiquitin-specific Protease 22	1827	23326	Gene	Gene	Levels|compound|START_ENTITY END_ENTITY|dep|Levels	Ubiquitin-specific_Protease_22 -LRB- USP22 -RRB- Positively Regulates RCAN1 Protein Levels through RCAN1 De-ubiquitination .
18022329	0	RCAN3	37,42	DSCR1L2	44,51	RCAN3	DSCR1L2	11123	11123	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Identification and analysis of human RCAN3 -LRB- DSCR1L2 -RRB- mRNA and protein isoforms .
22899815	0	RCC1	102,106	Nek8	117,121	RCC1	Nek8	682908(Tax:10116)	287473(Tax:10116)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	A novel mutation causing nephronophthisis in the Lewis_polycystic_kidney rat localises to a conserved RCC1 domain in Nek8 .
15782128	0	RCC1	107,111	PTEN	136,140	RCC1	PTEN	1104	5728	Gene	Gene	START_ENTITY|nmod|targets targets|nmod|END_ENTITY	Modulation of specific protein expression levels by PTEN : identification of AKAP121 , DHFR , G3BP , Rap1 , and RCC1 as potential targets of PTEN .
10471274	0	RCC1	104,108	Ran	57,60	RCC1	Ran	1104	5901	Gene	Gene	states|nmod|START_ENTITY states|nmod|END_ENTITY	Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1 .
11336674	0	RCC1	101,105	Ran	52,55	RCC1	Ran	1104	5901	Gene	Gene	regulator_of_chromosome_condensation|appos|START_ENTITY exchange|nmod|regulator_of_chromosome_condensation exchange|nmod|END_ENTITY	Structural basis for guanine_nucleotide exchange on Ran by the regulator_of_chromosome_condensation -LRB- RCC1 -RRB- .
1944575	0	RCC1	73,77	Ran	44,47	RCC1	Ran	1104	5901	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Catalysis of guanine_nucleotide exchange on Ran by the mitotic regulator RCC1 .
20565941	0	RCC1	34,38	Ran	106,109	RCC1	Ran	1104	5901	Gene	Gene	tail|nmod|START_ENTITY required|nsubjpass|tail required|nmod|END_ENTITY	The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells .
25452301	0	RCC1	54,58	Ran	18,21	RCC1	Ran	1104	5901	Gene	Gene	Oxidation|nmod|START_ENTITY Disruption|nmod|Oxidation Disruption|nmod|System System|compound|END_ENTITY	Disruption of the Ran System by Cysteine Oxidation of RCC1 .
7548002	0	RCC1	63,67	Ran	25,28	RCC1	Ran	1104	5901	Gene	Gene	catalyzed|nmod|START_ENTITY exchange|acl|catalyzed mechanism|dep|exchange mechanism|nmod|END_ENTITY	The kinetic mechanism of Ran -- nucleotide exchange catalyzed by RCC1 .
7738003	0	RCC1	4,8	Ran	32,35	RCC1	Ran	397722(Tax:8355)	100189578(Tax:8355)	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The RCC1 protein interacts with Ran , RanBP1 , hsc70 , and a 340-kDa protein in Xenopus extracts .
8864848	0	RCC1	32,36	Ran	78,81	RCC1	Ran	1104	5901	Gene	Gene	residues|nmod|START_ENTITY essential|nsubj|residues essential|nmod|exchange exchange|nmod|END_ENTITY	Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran .
8889801	0	RCC1	0,4	Ran	12,15	RCC1	Ran	1104	5901	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	RCC1 in the Ran pathway .
7616957	0	RCC1	66,70	RanBP1	0,6	RCC1	RanBP1	1104	5902	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	RanBP1 , a Ras-like nuclear G protein binding to Ran/TC4 , inhibits RCC1 via Ran/TC4 .
9178906	0	RCC1	16,20	c-myc	0,5	RCC1	c-myc	1104	4609	Gene	Gene	expression|nummod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	c-myc activates RCC1 gene expression through E-box elements .
11358836	0	RCC17	24,29	TFE3	38,42	RCC17	TFE3	79058	7030	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Fusion of a novel gene , RCC17 , to the TFE3 gene in t -LRB- X ; 17 -RRB- -LRB- p11 .2 ; q25 .3 -RRB- - bearing papillary_renal_cell_carcinomas .
19738201	0	RCC2	63,67	Rac1	91,95	RCC2	Rac1	55920	5879	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6 .
16926493	0	RCD1	51,55	RADICAL-INDUCED_CELL_DEATH1	22,49	RCD1	RADICAL-INDUCED CELL DEATH1	840115(Tax:3702)	840115(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Overexpression of the RADICAL-INDUCED_CELL_DEATH1 -LRB- RCD1 -RRB- gene of Arabidopsis causes weak rcd1 phenotype with compromised oxidative-stress responses .
23660188	0	RCK1	15,19	Kdx1	0,4	RCK1	Kdx1	852719(Tax:4932)	853696(Tax:4932)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Kdx1 regulates RCK1 gene expression by interacting with Rlm1 in Saccharomyces_cerevisiae .
20331974	0	RCOR2	8,13	ZMYND8	50,56	RCOR2	ZMYND8	431821(Tax:8355)	733267(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Xenopus RCOR2 -LRB- REST_corepressor_2 -RRB- interacts with ZMYND8 , which is involved in neural differentiation .
12447165	0	RCV1	22,26	Recoverin	11,20	RCV1	Recoverin	489500(Tax:9615)	489500(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The canine Recoverin -LRB- RCV1 -RRB- gene : a candidate gene for generalized progressive retinal_atrophy .
20470822	0	RD1	52,55	IFN-gamma	0,9	RD1	IFN-gamma	5158	3458	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	IFN-gamma , but not IP-10 , MCP-2 or IL-2 response to RD1 selected peptides associates to active_tuberculosis .
20470822	0	RD1	52,55	MCP-2	26,31	RD1	MCP-2	5158	6355	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	IFN-gamma , but not IP-10 , MCP-2 or IL-2 response to RD1 selected peptides associates to active_tuberculosis .
25176650	0	RD2	9,12	BCL6	4,8	RD2	BCL6	19133(Tax:10090)	12053(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers .
16463099	0	RD29B	71,76	ABI3	30,34	RD29B	ABI3	835306(Tax:3702)	822061(Tax:3702)	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Transcriptional regulation of ABI3 - and ABA-responsive genes including RD29B and RD29A in seeds , germinating embryos , and seedlings of Arabidopsis .
21928830	0	RD3	24,27	Retinal_degeneration_3	0,22	RD3	Retinal degeneration 3	343035	343035	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Retinal_degeneration_3 -LRB- RD3 -RRB- protein inhibits catalytic activity of retinal_membrane_guanylyl_cyclase -LRB- RetGC -RRB- and its stimulation by activating proteins .
12110183	0	RDE-1	47,52	RDE-4	26,31	RDE-1	RDE-4	179393(Tax:6239)	176438(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The dsRNA binding protein RDE-4 interacts with RDE-1 , DCR-1 , and a DExH-box helicase to direct RNAi in C. _ elegans .
15653635	0	RDE-2	0,5	MUT-7	21,26	RDE-2	MUT-7	172473(Tax:6239)	176347(Tax:6239)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis_elegans .
12110183	0	RDE-4	26,31	RDE-1	47,52	RDE-4	RDE-1	176438(Tax:6239)	179393(Tax:6239)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The dsRNA binding protein RDE-4 interacts with RDE-1 , DCR-1 , and a DExH-box helicase to direct RNAi in C. _ elegans .
14596915	0	RDH10	78,83	retinol_dehydrogenase_10	52,76	RDH10	retinol dehydrogenase 10	157506	157506	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and transcription of the human retinol_dehydrogenase_10 -LRB- RDH10 -RRB- gene .
18779497	0	RDH12	65,70	retinol_dehydrogenase_12	39,63	RDH12	retinol dehydrogenase 12	145226	145226	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a novel mutation in the retinol_dehydrogenase_12 -LRB- RDH12 -RRB- gene with autosomal_dominant_retinitis_pigmentosa .
9409819	0	RDH54	0,5	RAD54	9,14	RDH54	RAD54	852365(Tax:4932)	852713(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	RDH54 , a RAD54 homologue in Saccharomyces_cerevisiae , is required for mitotic diploid-specific recombination and repair and for meiosis .
22451137	0	RDHE2	61,66	retinal_short-chain_dehydrogenase_reductase	16,59	RDHE2	retinal short-chain dehydrogenase reductase	525500(Tax:9913)	525500(Tax:9913)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Major effect of retinal_short-chain_dehydrogenase_reductase -LRB- RDHE2 -RRB- on bovine fat colour .
23650562	0	RDS	45,48	retinal_degeneration_slow	18,43	RDS	retinal degeneration slow	19133(Tax:10090)	19133(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Overexpression of retinal_degeneration_slow -LRB- RDS -RRB- protein adversely affects rods in the rd7 model of enhanced_S-cone_syndrome .
8485576	0	RDS	50,53	retinal_degeneration_slow	23,48	RDS	retinal degeneration slow	5961	5961	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in the human retinal_degeneration_slow -LRB- RDS -RRB- gene can cause either retinitis_pigmentosa or macular_dystrophy .
24135225	0	RE-1_silencing_transcription_factor	19,54	REST	56,60	RE-1 silencing transcription factor	REST	5978	5978	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of RE-1_silencing_transcription_factor -LRB- REST -RRB- in advanced prostate_cancer by hypoxia-induced miR-106b ~ 25 .
12492469	0	RE-1_silencing_transcription_factor	0,35	synaptophysin	59,72	RE-1 silencing transcription factor	synaptophysin	5978	6855	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	RE-1_silencing_transcription_factor -LRB- REST -RRB- regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site .
26341630	0	RE1_silencing_transcription_factor	0,34	ALL1-fused_from_chromosome_1q	63,92	RE1 silencing transcription factor	ALL1-fused from chromosome 1q	5978	10962	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	RE1_silencing_transcription_factor -LRB- REST -RRB- negatively regulates ALL1-fused_from_chromosome_1q -LRB- AF1q -RRB- gene transcription .
19049968	0	RE1_silencing_transcription_factor	58,92	MED19	0,5	RE1 silencing transcription factor	MED19	5978	219541	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	MED19 and MED26 are synergistic functional targets of the RE1_silencing_transcription_factor in epigenetic silencing of neuronal gene expression .
10101155	0	REC104	57,63	REC102	99,105	REC104	REC102	856562(Tax:4932)	851040(Tax:4932)	Gene	Gene	analysis|nmod|START_ENTITY reveals|nsubj|analysis reveals|nmod|END_ENTITY	Suppressor analysis of the Saccharomyces_cerevisiae gene REC104 reveals a genetic interaction with REC102 .
10079324	0	REC3	6,10	RPD3	0,4	REC3	RPD3	855386(Tax:4932)	855386(Tax:4932)	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	RPD3 -LRB- REC3 -RRB- mutations affect mitotic recombination in Saccharomyces_cerevisiae .
16868028	0	REC8	24,28	afd1	11,15	REC8	afd1	732730(Tax:4577)	732730(Tax:4577)	Gene	Gene	functions|compound|START_ENTITY functions|amod|END_ENTITY	Alleles of afd1 dissect REC8 functions during meiotic prophase I. REC8 is a master regulator of chromatin structure and function during meiosis .
12810630	0	RECK	43,47	Histone_deacetylase	0,19	RECK	Histone deacetylase	8434	9734	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Histone_deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion .
26261088	0	RECK	6,10	MMP-9	0,5	RECK	MMP-9	8434	4318	Gene	Gene	Imbalance|compound|START_ENTITY Imbalance|compound|END_ENTITY	MMP-9 / RECK Imbalance : A Mechanism Associated with High-Grade Cervical Lesions_and_Genital_Infection_by_Human_Papillomavirus and Chlamydia_trachomatis .
26261088	0	RECK	6,10	MMP-9	0,5	RECK	MMP-9	8434	4318	Gene	Gene	Imbalance|compound|START_ENTITY Imbalance|compound|END_ENTITY	MMP-9 / RECK Imbalance : A Mechanism Associated with High-Grade Cervical Lesions_and_Genital_Infection_by_Human_Papillomavirus and Chlamydia_trachomatis .
24291500	0	RECK	43,47	farnesoid_X_receptor	14,34	RECK	farnesoid X receptor	53614(Tax:10090)	20186(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of farnesoid_X_receptor induces RECK expression in mouse liver .
19208844	0	RECK	0,4	matrix_metalloproteinase-9	26,52	RECK	matrix metalloproteinase-9	8434	4318	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	RECK negatively regulates matrix_metalloproteinase-9 transcription .
9789069	0	RECK	112,116	matrix_metalloproteinase-9	14,40	RECK	matrix metalloproteinase-9	8434	4318	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK .
26993249	0	RECK	75,79	miR-92b	0,7	RECK	miR-92b	8434	693235	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-92b promotes tumor proliferation , migration , and invasion by targeting RECK in osteosarcoma .
24366472	0	RECK	62,66	miR-96	0,6	RECK	miR-96	8434	407053	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-96 promotes tumor proliferation and invasion by targeting RECK in breast_cancer .
25663948	0	RECK	12,16	miR21	17,22	RECK	miR21	8434	406991	Gene	Gene	Cell|compound|START_ENTITY Cell|compound|END_ENTITY	Controlling RECK miR21 Promotes Tumor Cell Invasion and Is Related to Biochemical Recurrence in Prostate_Cancer .
25774876	0	RECQ1	0,5	FEN-1	21,26	RECQ1	FEN-1	5965	2237	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin .
25556649	0	RECQL4	0,6	p53	17,20	RECQL4	p53	9401	7157	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|xcomp|END_ENTITY	RECQL4 Regulates p53 Function In Vivo During Skeletogenesis .
25556649	0	RECQL4	0,6	p53	17,20	RECQL4	p53	9401	7157	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|xcomp|END_ENTITY	RECQL4 Regulates p53 Function In Vivo During Skeletogenesis .
19996311	0	REDD1	16,21	Insulin	0,7	REDD1	Insulin	54541	3630	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Insulin induces REDD1 expression through hypoxia-inducible_factor_1 activation in adipocytes .
19996311	0	REDD1	16,21	hypoxia-inducible_factor_1	41,67	REDD1	hypoxia-inducible factor 1	54541	3091	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|activation activation|amod|END_ENTITY	Insulin induces REDD1 expression through hypoxia-inducible_factor_1 activation in adipocytes .
23272222	0	REDD1	54,59	insulin	84,91	REDD1	insulin	54541	3630	Gene	Gene	-1|appos|START_ENTITY Regulated|dobj|-1 contributes|dep|Regulated contributes|nmod|END_ENTITY	Regulated in development and DNA damage responses -1 -LRB- REDD1 -RRB- protein contributes to insulin signaling pathway in adipocytes .
19795384	0	REDD1	14,19	insulin-like_growth_factor-I	23,51	REDD1	insulin-like growth factor-I	54541	3479	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of REDD1 by insulin-like_growth_factor-I in skeletal muscle and myotubes .
15545625	0	REDD1	54,59	mTOR	14,18	REDD1	mTOR	54541	21977(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 _ tumor suppressor complex .
18070882	0	REDD1	56,61	mTORC1	38,44	REDD1	mTORC1	54541	382056(Tax:10090)	Gene	Gene	repressor|dobj|START_ENTITY repressor|nsubj|turnover turnover|nmod|mTOR mTOR|appos|END_ENTITY	Rapid turnover of the mTOR complex 1 -LRB- mTORC1 -RRB- repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis .
19297425	0	REDD1	128,133	mTORC1	110,116	REDD1	mTORC1	140942(Tax:10116)	382056(Tax:10090)	Gene	Gene	repressor|appos|START_ENTITY repressor|amod|END_ENTITY	Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor , REDD1 .
20100206	0	REDD1	33,38	mTORC1	14,20	REDD1	mTORC1	54541	382056(Tax:10090)	Gene	Gene	induction|nummod|START_ENTITY activity|nmod|induction activity|amod|END_ENTITY	Inhibition of mTORC1 activity by REDD1 induction in myeloma cells resistant to bortezomib cytotoxicity .
23717519	0	REDD1	31,36	mTORC1	0,6	REDD1	mTORC1	54541	382056(Tax:10090)	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability regulation|amod|END_ENTITY	mTORC1 dependent regulation of REDD1 protein stability .
24018049	0	REDD1	43,48	mTORC1	194,200	REDD1	mTORC1	54541	382056(Tax:10090)	Gene	Gene	1|appos|START_ENTITY promotes|nsubj|1 promotes|advcl|sustaining sustaining|dobj|repression repression|appos|END_ENTITY	Regulated in DNA damage and development 1 -LRB- REDD1 -RRB- promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 -LRB- mTORC1 -RRB- .
24338366	0	REDD1	33,38	mTORC1	72,78	REDD1	mTORC1	54541	382056(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY contributes|nsubj|translocation contributes|nmod|activation activation|amod|END_ENTITY	Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation .
24876363	0	REDD1	62,67	mTORC1	29,35	REDD1	mTORC1	74747(Tax:10090)	382056(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY changes|nmod|expression result|nmod|changes END_ENTITY|nmod|result	Altered nutrient response of mTORC1 as a result of changes in REDD1 expression : effect of obesity vs. REDD1_deficiency .
25056877	0	REDD1	0,5	mTORC1	83,89	REDD1	mTORC1	74747(Tax:10090)	382056(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	REDD1 enhances protein phosphatase_2A-mediated dephosphorylation of Akt to repress mTORC1 signaling .
25159324	0	REDD1	8,13	mTORC1	54,60	REDD1	mTORC1	74747(Tax:10090)	382056(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY contributes|nsubj|expression contributes|nmod|activation activation|nmod|following following|amod|END_ENTITY	Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction .
25539833	0	REDD1	27,32	mTORC1	70,76	REDD1	mTORC1	140942(Tax:10116)	382056(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY signaling|nsubj|expression signaling|dep|END_ENTITY	Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle .
26487002	0	REDD1	14,19	mTORC1	64,70	REDD1	mTORC1	74747(Tax:10090)	382056(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Disruption|nmod|gene ameliorates|nsubj|Disruption ameliorates|nmod|signaling signaling|amod|END_ENTITY	Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle .
12453409	0	REDD1	0,5	p63	61,64	REDD1	p63	74747(Tax:10090)	22061(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	REDD1 , a developmentally regulated transcriptional target of p63 and p53 , links p63 to regulation of reactive oxygen species .
12453409	0	REDD1	0,5	p63	80,83	REDD1	p63	74747(Tax:10090)	22061(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	REDD1 , a developmentally regulated transcriptional target of p63 and p53 , links p63 to regulation of reactive oxygen species .
19268525	0	REDD2	56,61	regulated_in_development_and_DNA_damage_response_2	4,54	REDD2	regulated in development and DNA damage response 2	115265	115265	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The regulated_in_development_and_DNA_damage_response_2 -LRB- REDD2 -RRB- gene mediates human monocyte cell death through a reduction in thioredoxin-1 expression .
18644145	0	REEP1	73,78	SPG31	85,90	REEP1	SPG31	65055	65055	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Autosomal_dominant_hereditary_spastic_paraplegia : novel mutations in the REEP1 gene -LRB- SPG31 -RRB- .
21618648	0	REEP1	0,5	SPG31	19,24	REEP1	SPG31	65055	65055	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	REEP1 mutations in SPG31 : frequency , mutational spectrum , and potential association with mitochondrial_morpho-functional_dysfunction .
20200447	0	REEP1	39,44	spastin	46,53	REEP1	spastin	362384(Tax:10116)	362700(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Hereditary spastic_paraplegia proteins REEP1 , spastin , and atlastin-1 coordinate microtubule interactions with the tubular ER network .
22761374	0	REF/Aly	34,41	ORF57	92,97	REF/Aly	ORF57	10189	4961525(Tax:37296)	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Binding of cellular export factor REF/Aly by Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- ORF57 protein is not required for efficient KSHV lytic replication .
26387746	0	REG4	0,4	GATA6	36,41	REG4	GATA6	83998	2627	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis .
27036049	0	REG4	0,4	GPR37	62,67	REG4	GPR37	83998	2861	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	REG4 promotes peritoneal metastasis of gastric_cancer through GPR37 .
21216954	0	REGgamma	53,61	p30	34,37	REGgamma	p30	10197	201161	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human_T-lymphotropic_virus_type_1 p30 interacts with REGgamma and modulates ATM _ -LRB- ataxia_telangiectasia_mutated -RRB- to promote cell survival .
21084564	0	REGgamma	0,8	p53	19,22	REGgamma	p53	10197	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	REGgamma modulates p53 activity by regulating its cellular localization .
20826731	0	RELA	77,81	IL6	93,96	RELA	IL6	19697(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|dep|pathway pathway|nummod|END_ENTITY	Neuromedin_B and its receptor induce labor onset and are associated with the RELA -LRB- NFKB_P65 -RRB- / IL6 pathway in pregnant mice .
22891766	0	RELA	37,41	TWIST1	0,6	RELA	TWIST1	5970	7291	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	TWIST1 associates with NF-kB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production .
26285214	0	RELM-b	20,26	CD4	36,39	RELM-b	CD4	57263(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Goblet Cell Derived RELM-b Recruits CD4 + T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation .
26285214	0	RELM-b	20,26	CD4	36,39	RELM-b	CD4	57263(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Goblet Cell Derived RELM-b Recruits CD4 + T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation .
20727978	0	RELN	12,16	Reelin	4,10	RELN	Reelin	5649	5649	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The Reelin -LRB- RELN -RRB- gene is associated with executive function in healthy individuals .
15717292	0	RELN	32,36	reelin	24,30	RELN	reelin	5649	5649	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Hypermethylation of the reelin -LRB- RELN -RRB- promoter in the brain of schizophrenic patients : a preliminary report .
20734148	0	RELN	30,34	reelin	22,28	RELN	reelin	5649	5649	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Reduced expression of reelin -LRB- RELN -RRB- gene is associated with high recurrence rate of hepatocellular_carcinoma .
21863557	0	RELN	59,63	reelin	51,57	RELN	reelin	5649	5649	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new single-nucleotide mutation -LRB- rs362719 -RRB- of the reelin -LRB- RELN -RRB- gene associated with schizophrenia in female Chinese Han .
16323007	0	RELP	19,23	Reg_IV	25,31	RELP	Reg IV	83998	83998	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High expression of RELP -LRB- Reg_IV -RRB- in neoplastic goblet cells of appendiceal mucinous_cystadenoma and pseudomyxoma_peritonei .
26495141	0	REN	28,31	Renin	42,47	REN	Renin	5972	5972	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Genetic Variants of C-5312T REN Increased Renin Levels and Diastolic Blood Pressure Response to Angiotensin Receptor Blockers .
22216185	0	REN	56,59	mTOR	37,41	REN	mTOR	5972	21977(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY inhibition|nmod|cells inhibition|compound|END_ENTITY	Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1 .
26102248	0	REN	52,55	renin	45,50	REN	renin	5972	5972	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The C4280A -LRB- rs5705 -RRB- gene polymorphism of the renin -LRB- REN -RRB- gene is associated with risk of developing coronary_artery_disease , but not with restenosis after coronary stenting .
2852136	0	REO1	18,22	COX5b	66,71	REO1	COX5b	856178(Tax:4932)	854695(Tax:4932)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of REO1 , a gene involved in negative regulation of COX5b and ANB1 in aerobically grown Saccharomyces_cerevisiae .
15186776	0	REP-1	22,27	Rab7	17,21	REP-1	Rab7	1121	338382	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Structure of the Rab7 : REP-1 complex : insights into the mechanism of Rab prenylation and choroideremia disease .
9067750	0	REP-1	86,91	Rab_escort_protein-1	64,84	REP-1	Rab escort protein-1	1121	1121	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular basis of choroideremia -LRB- CHM -RRB- : mutations involving the Rab_escort_protein-1 -LRB- REP-1 -RRB- gene .
10447648	0	REP-1	0,5	choroideremia	47,60	REP-1	choroideremia	1121	1121	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	REP-1 gene mutations in Japanese patients with choroideremia .
17951542	0	RESP18	0,6	IA-2	40,44	RESP18	IA-2	389075	5798	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	RESP18 , a homolog of the luminal domain IA-2 , is found in dense core vesicles in pancreatic islet cells and is induced by high glucose .
8132649	0	RESP18	0,6	pro-opiomelanocortin	114,134	RESP18	pro-opiomelanocortin	50561(Tax:10116)	24664(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	RESP18 , a novel endocrine secretory protein transcript , and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes .
25220237	0	REST	66,70	PDYN	0,4	REST	PDYN	5978	5173	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	PDYN , a gene implicated in brain/mental _ disorders , is targeted by REST in the adult human brain .
24135225	0	REST	56,60	RE-1_silencing_transcription_factor	19,54	REST	RE-1 silencing transcription factor	5978	5978	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of RE-1_silencing_transcription_factor -LRB- REST -RRB- in advanced prostate_cancer by hypoxia-induced miR-106b ~ 25 .
21179468	0	REST	30,34	Sp1	38,41	REST	Sp1	19712(Tax:10090)	20683(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of REST by Sp1 in Huntington 's _ disease models .
25843715	0	REST	21,25	TET3	0,4	REST	TET3	19712(Tax:10090)	194388(Tax:10090)	Gene	Gene	Recruited|nmod|START_ENTITY Recruited|nsubjpass|END_ENTITY	TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression .
23708518	0	REST	54,58	USP15	19,24	REST	USP15	5978	9958	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit .
17944879	0	REST	0,4	brain-specific_homeobox	27,50	REST	brain-specific homeobox	19712(Tax:10090)	244813(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	REST is a key regulator in brain-specific_homeobox gene expression during neuronal differentiation .
14643653	0	REST	71,75	repressor_element_1-silencing_transcription_factor	19,69	REST	repressor element 1-silencing transcription factor	5978	5978	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the repressor_element_1-silencing_transcription_factor -LRB- REST -RRB- with target genes .
20644217	0	RET	33,36	CK19	27,31	RET	CK19	5979	3880	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Diagnostic significance of CK19 , RET , galectin-3 and HBME-1 expression for papillary_thyroid_carcinoma .
21454698	0	RET	34,37	Focal_adhesion_kinase	0,21	RET	Focal adhesion kinase	5979	5747	Gene	Gene	kinase|compound|START_ENTITY binds|dobj|kinase binds|nsubj|END_ENTITY	Focal_adhesion_kinase -LRB- FAK -RRB- binds RET kinase via its FERM domain , priming a direct and reciprocal RET-FAK transactivation mechanism .
10023033	0	RET	29,32	GDNF	14,18	RET	GDNF	5979	2668	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of GDNF receptor -LRB- RET and GDNFR-alpha -RRB- mRNAs in the spinal cord of patients with amyotrophic_lateral_sclerosis .
12917638	0	RET	16,19	Grap-2	0,6	RET	Grap-2	19713(Tax:10090)	17444(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Grap-2 , a novel RET binding protein , is involved in RET mitogenic signaling .
25168352	0	RET	33,36	IL-10	47,52	RET	IL-10	19713(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	The neurotrophic factor receptor RET regulates IL-10 production by in vitro polarised T helper 2 cells .
7824936	0	RET	14,17	MEN2A	75,80	RET	MEN2A	5979	5979	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of RET as a dominant transforming gene by germline mutations of MEN2A and MEN2B .
8570194	0	RET	0,3	MEN2A	27,32	RET	MEN2A	5979	5979	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	RET activation by germline MEN2A and MEN2B mutations .
7915165	0	RET	9,12	MEN_2A	26,32	RET	MEN 2A	5979	5979	Gene	Gene	mutations|nsubj|START_ENTITY mutations|nmod|END_ENTITY	Germline RET mutations in MEN_2A and FMTC and their detection by simple DNA diagnostic tests .
19853745	0	RET	30,33	Nkx2-1	37,43	RET	Nkx2-1	5979	7080	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of RET by Nkx2-1 , Phox2b , Sox10 , and Pax3 .
20533997	0	RET	16,19	Nurr1	0,5	RET	Nurr1	24716(Tax:10116)	54278(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain .
9047383	0	RET	0,3	RET	63,66	RET	RET	5979	5979	Gene	Gene	splicing|compound|START_ENTITY influences|nsubj|splicing influences|dobj|interaction interaction|nmod|END_ENTITY	RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc , and the SH2 domain of Grb2 .
9047383	0	RET	63,66	RET	0,3	RET	RET	5979	5979	Gene	Gene	interaction|nmod|START_ENTITY influences|dobj|interaction influences|nsubj|splicing splicing|compound|END_ENTITY	RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc , and the SH2 domain of Grb2 .
20877310	0	RET	23,26	Rap1GAP	0,7	RET	Rap1GAP	5979	5909	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth .
9047383	0	RET	0,3	Shc	99,102	RET	Shc	5979	6464	Gene	Gene	splicing|compound|START_ENTITY influences|nsubj|splicing influences|dobj|interaction interaction|nmod|END_ENTITY	RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc , and the SH2 domain of Grb2 .
9047383	0	RET	63,66	Shc	99,102	RET	Shc	5979	6464	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc , and the SH2 domain of Grb2 .
15657578	0	RET	0,3	focal_adhesion_kinase	20,41	RET	focal adhesion kinase	19713(Tax:10090)	14083(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	RET signals through focal_adhesion_kinase in medullary_thyroid_cancer cells .
16424056	0	RET	17,20	multiple_endocrine_neoplasia_type_2A	77,113	RET	multiple endocrine neoplasia type 2A	5979	5979	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms in RET and its coreceptors and ligands as genetic modifiers of multiple_endocrine_neoplasia_type_2A .
24169328	0	RET	27,30	multiple_endocrine_neoplasia_type_2A	87,123	RET	multiple endocrine neoplasia type 2A	5979	5979	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The clinical patterns and RET proto-oncogene identification of pheochromocytoma in 13 multiple_endocrine_neoplasia_type_2A pedigrees -RSB- .
18316595	0	RET	32,35	p18	48,51	RET	p18	19713(Tax:10090)	12580(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of oncogenic RET and loss of p18 on medullary_thyroid_carcinoma development .
21112821	0	RET	134,137	p18	96,99	RET	p18	5979	1031	Gene	Gene	required|nmod|START_ENTITY required|nmod|regulation regulation|nmod|END_ENTITY	N-Myc is a downstream target of RET signaling and is required for transcriptional regulation of p18 -LRB- Ink4c -RRB- by the transforming mutant RET -LRB- C634R -RRB- .
7633441	0	RET	25,28	receptor_tyrosine_kinase	29,53	RET	receptor tyrosine kinase	5979	5979	Gene	Gene	analysis|nmod|START_ENTITY END_ENTITY|nsubj|analysis	Mutation analysis of the RET receptor_tyrosine_kinase in Hirschsprung_disease .
12325031	0	RETGC1	37,43	GUCY2D	45,51	RETGC1	GUCY2D	3000	3000	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Evidence of a founder effect for the RETGC1 -LRB- GUCY2D -RRB- 2943DelG mutation in Leber_congenital_amaurosis pedigrees of Finnish origin .
17872382	0	REV-ERB_alpha	50,63	OTX5	0,4	REV-ERB alpha	OTX5	494487(Tax:7955)	353179(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	OTX5 regulates pineal expression of the zebrafish REV-ERB_alpha through a new DNA binding site .
22761336	0	REV1	21,25	MiR-96	0,6	REV1	MiR-96	51455	407053	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition .
16857592	0	REV1	0,4	PCNA	28,32	REV1	PCNA	418703(Tax:9031)	373984(Tax:9031)	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	REV1 protein interacts with PCNA : significance of the REV1 BRCT domain in vitro and in vivo .
16857592	0	REV1	54,58	PCNA	28,32	REV1	PCNA	418703(Tax:9031)	373984(Tax:9031)	Gene	Gene	domain|compound|START_ENTITY significance|nmod|domain interacts|dep|significance interacts|nmod|END_ENTITY	REV1 protein interacts with PCNA : significance of the REV1 BRCT domain in vitro and in vivo .
26795561	0	REV1	0,4	PCNA	14,18	REV1	PCNA	51455	5111	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|monoubiquitination monoubiquitination|compound|END_ENTITY	REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18 .
25455130	0	REX-1	30,35	IL-6	0,4	REX-1	IL-6	57455	3569	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-6 regulates stress-induced REX-1 expression via ATP-P2Y1 signalling in stem cells isolated from human exfoliated deciduous teeth .
18237746	0	REX1	112,116	ZFP-42	118,124	REX1	ZFP-42	132625	132625	Gene	Gene	cells|nummod|START_ENTITY cells|appos|END_ENTITY	Transcriptional activation of the suppressor_of_cytokine_signaling-3 -LRB- SOCS-3 -RRB- gene via STAT3 is increased in F9 REX1 -LRB- ZFP-42 -RRB- knockout teratocarcinoma stem cells relative to wild-type cells .
21325049	0	RF-amide-related_peptide	25,49	RFRP	51,55	RF-amide-related peptide	RFRP	60531(Tax:10090)	60531(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Estradiol down-regulates RF-amide-related_peptide -LRB- RFRP -RRB- expression in the mouse hypothalamus .
22890010	0	RFC-1	40,45	COMT	15,19	RFC-1	COMT	5981	1312	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of COMT , MTHFR , and SLC19A1 -LRB- RFC-1 -RRB- polymorphisms with homocysteine blood levels and cognitive_impairment in Parkinson 's _ disease .
10517667	0	RFG	0,3	androgen_receptor	43,60	RFG	androgen receptor	8031	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RFG -LRB- ARA70 , ELE1 -RRB- interacts with the human androgen_receptor in a ligand-dependent fashion , but functions only weakly as a coactivator in cotransfection assays .
21325049	0	RFRP	51,55	RF-amide-related_peptide	25,49	RFRP	RF-amide-related peptide	60531(Tax:10090)	60531(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Estradiol down-regulates RF-amide-related_peptide -LRB- RFRP -RRB- expression in the mouse hypothalamus .
18617612	0	RFRP	53,57	RFamide-related_peptide	28,51	RFRP	RFamide-related peptide	100127217(Tax:9940)	100127217(Tax:9940)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Variation in kisspeptin and RFamide-related_peptide -LRB- RFRP -RRB- expression and terminal connections to gonadotropin-releasing hormone neurons in the brain : a novel medium for seasonal breeding in the sheep .
20484689	0	RFRP	95,99	RFamide-related_peptide	70,93	RFRP	RFamide-related peptide	101830831	101830831	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Photoperiod and reproductive condition are associated with changes in RFamide-related_peptide -LRB- RFRP -RRB- expression in Syrian_hamsters -LRB- Mesocricetus_auratus -RRB- .
1712681	0	RFT2	65,69	CD7	79,82	RFT2	CD7	113278	924	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of lymphocyte proliferation by a monoclonal antibody -LRB- RFT2 -RRB- against CD7 .
10767550	0	RFX	67,70	dRFX	32,36	RFX	dRFX	41266(Tax:7227)	41266(Tax:7227)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Cloning and characterization of dRFX , the Drosophila member of the RFX family of transcription factors .
10725724	0	RFX-B	27,32	MHC	60,63	RFX-B	MHC	8625	3133	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class_II_transactivator in RFX-B-deficient cells .
21192791	0	RFX1	0,4	CD70	15,19	RFX1	CD70	5989	970	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	RFX1 regulates CD70 and CD11a expression in lupus_T cells by recruiting the histone methyltransferase SUV39H1 .
20189986	0	RFX1	62,66	FGF1	14,18	RFX1	FGF1	5989	2246	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of FGF1 gene promoter through transcription factor RFX1 .
15526285	0	RFX2	70,74	H1t	58,61	RFX2	H1t	301121(Tax:10116)	24438(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of the testis-specific histone H1t gene by RFX2 may require both proximal promoter X-box elements .
16730065	0	RFX5	36,40	CREB	0,4	RFX5	CREB	5993	1385	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	CREB and phospho-CREB interact with RFX5 and CIITA to regulate MHC class II genes .
23079621	0	RFX5	19,23	collagen_type_I	54,69	RFX5	collagen type I	5993	1278	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	SIRT1 deacetylates RFX5 and antagonizes repression of collagen_type_I -LRB- COL1A2 -RRB- transcription in smooth muscle cells .
25497100	0	RFX6	0,4	Insulin	15,22	RFX6	Insulin	222546	3630	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	RFX6 Regulates Insulin Secretion by Modulating Ca -LRB- 2 + -RRB- Homeostasis in Human b Cells .
18617612	0	RFamide-related_peptide	28,51	RFRP	53,57	RFamide-related peptide	RFRP	100127217(Tax:9940)	100127217(Tax:9940)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Variation in kisspeptin and RFamide-related_peptide -LRB- RFRP -RRB- expression and terminal connections to gonadotropin-releasing hormone neurons in the brain : a novel medium for seasonal breeding in the sheep .
20484689	0	RFamide-related_peptide	70,93	RFRP	95,99	RFamide-related peptide	RFRP	101830831	101830831	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Photoperiod and reproductive condition are associated with changes in RFamide-related_peptide -LRB- RFRP -RRB- expression in Syrian_hamsters -LRB- Mesocricetus_auratus -RRB- .
22355072	0	RFamide-related_peptide	72,95	Rfrp	97,101	RFamide-related peptide	Rfrp	60531(Tax:10090)	60531(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Development , sex steroid regulation , and phenotypic characterization of RFamide-related_peptide -LRB- Rfrp -RRB- gene expression and RFamide receptors in the mouse hypothalamus .
25418473	0	RGC-32	32,38	Response_gene_to_complement_32	0,30	RGC-32	Response gene to complement 32	28984	28984	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Response_gene_to_complement_32 -LRB- RGC-32 -RRB- expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4 .
7498475	0	RGL	51,54	p21	42,45	RGL	p21	23179	1026	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|interaction interaction|nmod|END_ENTITY	rap1_p21 regulates the interaction of ras p21 with RGL , a new effector protein of ras p21 .
7498475	0	RGL	51,54	p21	86,89	RGL	p21	23179	1026	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	rap1_p21 regulates the interaction of ras p21 with RGL , a new effector protein of ras p21 .
16836993	0	RGMa	24,28	Neogenin	0,8	RGMa	Neogenin	380244(Tax:8355)	100381051(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain .
17953666	0	RGMa	0,4	neogenin	99,107	RGMa	neogenin	244058(Tax:10090)	18007(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|system system|nmod|receptor receptor|compound|END_ENTITY	RGMa inhibits neurite outgrowth of neuronal progenitors from murine enteric nervous system via the neogenin receptor in vitro .
25085051	0	RGMb	45,49	repulsive_guidance_molecule_b	14,43	RGMb	repulsive guidance molecule b	681433(Tax:10116)	681433(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of repulsive_guidance_molecule_b -LRB- RGMb -RRB- in the uterus and ovary during the estrous cycle in rats .
21779798	0	RGN	58,61	regucalcin	46,56	RGN	regucalcin	100653478	100653478	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparative molecular characterization of the regucalcin -LRB- RGN -RRB- gene in rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- and maraena whitefish -LRB- Coregonus marena -RRB- .
21951853	0	RGN	49,52	regucalcin	37,47	RGN	regucalcin	403070(Tax:7955)	403070(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Senescence marker protein 30 -LRB- SMP30 -RRB- / regucalcin -LRB- RGN -RRB- expression decreases with aging , acute liver_injuries and tumors in zebrafish .
23295489	0	RGS	145,148	CG5036	159,165	RGS	CG5036	5308	37037(Tax:7227)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Crystallization and preliminary X-ray diffraction studies of Drosophila_melanogaster Gao-subunit of heterotrimeric G protein in complex with the RGS domain of CG5036 .
9789084	0	RGS	69,72	RGS11	53,58	RGS	RGS11	5308	8786	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits .
12761220	0	RGS	117,120	RGS6	102,106	RGS	RGS6	5308	9628	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins .
26811338	0	RGS	125,128	Regulators_of_G_protein_Signaling	90,123	RGS	Regulators of G protein Signaling	5308	5308	Gene	Gene	Proteins|appos|START_ENTITY Proteins|compound|END_ENTITY	Association with the Plasma Membrane is Sufficient for Potentiating Catalytic Activity of Regulators_of_G_protein_Signaling -LRB- RGS -RRB- Proteins of the R7 subfamily .
9813023	0	RGS	35,38	Regulators_of_G_protein_signaling	0,33	RGS	Regulators of G protein signaling	5308	5308	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Regulators_of_G_protein_signaling -LRB- RGS -RRB- proteins constitutively activate Gbeta gamma-gated potassium channels .
12062898	0	RGS	69,72	gonadotropin-releasing_hormone_receptor	18,57	RGS	gonadotropin-releasing hormone receptor	5308	2798	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Regulation of the gonadotropin-releasing_hormone_receptor -LRB- GnRHR -RRB- by RGS proteins : role of the GnRHR carboxyl-terminus .
14992813	0	RGS	59,62	regulators_of_G-protein_signaling	24,57	RGS	regulators of G-protein signaling	5308	5308	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Selective expression of regulators_of_G-protein_signaling -LRB- RGS -RRB- in the human central nervous system .
15830230	0	RGS	63,66	regulators_of_G_protein_signalling	27,61	RGS	regulators of G protein signalling	5308	5308	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Effector antagonism by the regulators_of_G_protein_signalling -LRB- RGS -RRB- proteins causes desensitization of mu-opioid receptors in the CNS .
11996904	0	RGS-2	28,33	Parathyroid_hormone	0,19	RGS-2	Parathyroid hormone	19735(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Parathyroid_hormone induces RGS-2 expression by a cyclic_adenosine_3 ' ,5 ' - monophosphate-mediated pathway in primary neonatal murine osteoblasts .
11968023	0	RGS-2	48,53	regulator_of_G-protein_signaling-2	12,46	RGS-2	regulator of G-protein signaling-2	84583(Tax:10116)	84583(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of regulator_of_G-protein_signaling-2 -LRB- RGS-2 -RRB- expression and function in osteoblastic cells .
17077144	0	RGS-PX1	18,25	sorting_nexin_13	26,42	RGS-PX1	sorting nexin 13	217463(Tax:10090)	217463(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Essential role of RGS-PX1 / sorting_nexin_13 in mouse development and regulation of endocytosis dynamics .
23533674	0	RGS10	116,121	regulator_of_G-protein_signaling_10	79,114	RGS10	regulator of G-protein signaling 10	6001	6001	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional suppression , DNA methylation , and histone deacetylation of the regulator_of_G-protein_signaling_10 -LRB- RGS10 -RRB- gene in ovarian_cancer cells .
9789084	0	RGS11	53,58	RGS	69,72	RGS11	RGS	8786	5308	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits .
21531726	0	RGS13	25,30	p53	0,3	RGS13	p53	246709(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p53 negatively regulates RGS13 protein expression in immune cells .
10926822	0	RGS14	0,5	Rap	17,20	RGS14	Rap	51791(Tax:10090)	16976(Tax:10090)	Gene	Gene	effector|nsubj|START_ENTITY effector|compound|END_ENTITY	RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao .
23817783	0	RGS14	75,80	regulator_of_G_protein_signaling_14	38,73	RGS14	regulator of G protein signaling 14	51791(Tax:10090)	51791(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Postnatal developmental expression of regulator_of_G_protein_signaling_14 -LRB- RGS14 -RRB- in the mouse brain .
10760272	0	RGS16	83,88	MIR16	0,5	RGS16	MIR16	6004	51573	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MIR16 , a putative membrane glycerophosphodiester phosphodiesterase , interacts with RGS16 .
15998835	0	RGS16	0,5	SDF-1-CXCR4	33,44	RGS16	SDF-1-CXCR4	6004	6387;7852	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes .
26013170	0	RGS16	17,22	miR-181a	0,8	RGS16	miR-181a	6004	387176(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Targets Targets|amod|END_ENTITY	miR-181a Targets RGS16 to Promote Chondrosarcoma_Growth , Angiogenesis , and Metastasis .
21620966	0	RGS17	72,77	regulator_of_G-protein_signaling-17	35,70	RGS17	regulator of G-protein signaling-17	26575	26575	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Altered expression and function of regulator_of_G-protein_signaling-17 -LRB- RGS17 -RRB- in hepatocellular_carcinoma .
20562099	0	RGS19	48,53	regulator_of_G_protein_signaling_19	11,46	RGS19	regulator of G protein signaling 19	56470(Tax:10090)	56470(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of regulator_of_G_protein_signaling_19 -LRB- RGS19 -RRB- on heart development and function .
24398995	0	RGS2	62,66	COL6A3	68,74	RGS2	COL6A3	378912(Tax:9031)	396548(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	RGS2	62,66	EDNRB	76,81	RGS2	EDNRB	378912(Tax:9031)	408082(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
23587726	0	RGS2	68,72	HSF1	109,113	RGS2	HSF1	5997	3297	Gene	Gene	transcription|appos|START_ENTITY transcription|nmod|END_ENTITY	Stress-induced transcription of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- by heat_shock transcription factor HSF1 .
24398995	0	RGS2	62,66	IGF2R	55,60	RGS2	IGF2R	378912(Tax:9031)	395817(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	RGS2	62,66	KLF6	83,87	RGS2	KLF6	378912(Tax:9031)	420463(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
22120521	0	RGS2	0,4	Nox1	47,51	RGS2	Nox1	5997	27035	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	RGS2 is a negative regulator of STAT3-mediated Nox1 expression .
16895908	0	RGS2	0,4	TRPV6	42,47	RGS2	TRPV6	5997	55503	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	RGS2 inhibits the epithelial Ca2 + channel TRPV6 .
10692485	0	RGS2	23,27	angiotensin_II	45,59	RGS2	angiotensin II	5997	183	Gene	Gene	RNA|compound|START_ENTITY RNA|nmod|END_ENTITY	Specific regulation of RGS2 messenger RNA by angiotensin_II in cultured vascular smooth muscle cells .
16627589	0	RGS2	0,4	angiotensin_II	21,35	RGS2	angiotensin II	5997	183	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	RGS2 is regulated by angiotensin_II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells .
16685212	0	RGS2	58,62	angiotensin_II	158,172	RGS2	angiotensin II	5997	183	Gene	Gene	regulator_of_G-protein_signaling_2|appos|START_ENTITY expression|nmod|regulator_of_G-protein_signaling_2 increases|nsubj|expression increases|dobj|mobilization mobilization|acl|induced induced|nmod|END_ENTITY	Reduced expression of regulator_of_G-protein_signaling_2 -LRB- RGS2 -RRB- in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin_II .
22057271	0	RGS2	136,140	angiotensin_II	171,185	RGS2	angiotensin II	5997	183	Gene	Gene	element|nmod|START_ENTITY element|nmod|element Identification|nmod|element transcriptional|nsubj|Identification transcriptional|nmod|END_ENTITY	Identification of a cAMP-response element in the regulator_of_G-protein_signaling-2 -LRB- RGS2 -RRB- promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin_II in cultured vascular smooth muscles .
22057271	0	RGS2	85,89	angiotensin_II	171,185	RGS2	angiotensin II	5997	183	Gene	Gene	promoter|appos|START_ENTITY element|nmod|promoter Identification|nmod|element transcriptional|nsubj|Identification transcriptional|nmod|END_ENTITY	Identification of a cAMP-response element in the regulator_of_G-protein_signaling-2 -LRB- RGS2 -RRB- promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin_II in cultured vascular smooth muscles .
22080612	0	RGS2	32,36	b2-Adrenoceptor	0,15	RGS2	b2-Adrenoceptor	5997	154	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	b2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids .
24398995	0	RGS2	62,66	folr1	48,53	RGS2	folr1	378912(Tax:9031)	395638(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
11573967	0	RGS2	10,14	parathyroid_hormone	45,64	RGS2	parathyroid hormone	84583(Tax:10116)	24694(Tax:10116)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Inducible RGS2 is a cross-talk regulator for parathyroid_hormone signaling in rat osteoblast-like UMR106 cells .
22057271	0	RGS2	85,89	regulator_of_G-protein_signaling-2	49,83	RGS2	regulator of G-protein signaling-2	5997	5997	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Identification of a cAMP-response element in the regulator_of_G-protein_signaling-2 -LRB- RGS2 -RRB- promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin_II in cultured vascular smooth muscles .
17294519	0	RGS2	44,48	regulator_of_G-protein_signaling_2	8,42	RGS2	regulator of G-protein signaling 2	5997	5997	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of regulator_of_G-protein_signaling_2 -LRB- RGS2 -RRB- in periodontal ligament cells under mechanical stress .
12968938	0	RGS2	59,63	regulator_of_G-protein_signalling_protein_2	14,57	RGS2	regulator of G-protein signalling protein 2	19735(Tax:10090)	19735(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of regulator_of_G-protein_signalling_protein_2 -LRB- RGS2 -RRB- in the mouse uterus at implantation sites .
15292238	0	RGS2	134,138	regulator_of_G_protein_signaling_2	8,42	RGS2	regulator of G protein signaling 2	19735(Tax:10090)	19735(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- in Ca -LRB- 2 + -RRB- oscillations and adaptation of Ca -LRB- 2 + -RRB- signaling to reduce excitability of RGS2 - / - cells .
18726905	0	RGS2	94,98	regulator_of_G_protein_signaling_2	58,92	RGS2	regulator of G protein signaling 2	19735(Tax:10090)	19735(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the transcriptional regulation of the regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- gene during 3T3-L1 preadipocyte differentiation .
20032508	0	RGS2	53,57	regulator_of_G_protein_signaling_2	17,51	RGS2	regulator of G protein signaling 2	84583(Tax:10116)	84583(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Ischemia induces regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- protein upregulation and enhances apoptosis in astrocytes .
23587726	0	RGS2	68,72	regulator_of_G_protein_signaling_2	32,66	RGS2	regulator of G protein signaling 2	5997	5997	Gene	Gene	transcription|appos|START_ENTITY transcription|nmod|END_ENTITY	Stress-induced transcription of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- by heat_shock transcription factor HSF1 .
11985497	0	RGS3	0,4	14-3-3	20,26	RGS3	14-3-3	5998	10971	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS -LRB- regulator_of_G-protein_signalling -RRB- domain .
22027839	0	RGS3	104,108	14-3-3	25,31	RGS3	14-3-3	5998	10971	Gene	Gene	function|appos|START_ENTITY basis|nmod|function basis|nmod|inhibition inhibition|nummod|END_ENTITY	Structural basis for the 14-3-3 protein-dependent inhibition of the regulator_of_G_protein_signaling_3 -LRB- RGS3 -RRB- function .
26416661	0	RGS3	73,77	microRNA-25	9,20	RGS3	microRNA-25	5998	407014	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Elevated microRNA-25 inhibits cell apoptosis in lung_cancer by targeting RGS3 .
19369446	0	RGS4	16,20	IL-1beta	35,43	RGS4	IL-1beta	100009014(Tax:9986)	100008990(Tax:9986)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway .
18260825	0	RGS4	31,35	Interleukin-1beta	0,17	RGS4	Interleukin-1beta	100009014(Tax:9986)	100008990(Tax:9986)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Interleukin-1beta up-regulates RGS4 through the canonical IKK2/IkappaBalpha/NF-kappaB pathway in rabbit colonic smooth muscle .
22562250	0	RGS4	27,31	mTOR	35,39	RGS4	mTOR	5999	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment .
11326297	0	RGS4	64,68	regulator_of_G-protein_signaling_4	28,62	RGS4	regulator of G-protein signaling 4	5999	5999	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Disease-specific changes in regulator_of_G-protein_signaling_4 -LRB- RGS4 -RRB- expression in schizophrenia .
24229325	0	RGS4	78,82	regulator_of_G-protein_signaling_4	42,76	RGS4	regulator of G-protein signaling 4	5999	5999	Gene	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Modification and functional inhibition of regulator_of_G-protein_signaling_4 -LRB- RGS4 -RRB- by 4-hydroxy-2-nonenal .
17071056	0	RGS4	59,63	regulator_of_G-protein_signalling_4	22,57	RGS4	regulator of G-protein signalling 4	5999	5999	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Altered expression of regulator_of_G-protein_signalling_4 -LRB- RGS4 -RRB- mRNA in the superior temporal gyrus in schizophrenia .
23977258	0	RGS4	103,107	regulator_of_G_protein_signaling_4	67,101	RGS4	regulator of G protein signaling 4	29480(Tax:10116)	29480(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Splicing factor transformer-2b -LRB- Tra2b -RRB- regulates the expression of regulator_of_G_protein_signaling_4 -LRB- RGS4 -RRB- gene and is induced by morphine .
9207071	0	RGS4	55,59	regulators_of_G_protein_signaling	4,37	RGS4	regulators of G protein signaling	5999	5308	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	The regulators_of_G_protein_signaling -LRB- RGS -RRB- domains of RGS4 , RGS10 , and GAIP retain GTPase activating protein activity in vitro .
25842189	0	RGS5	14,18	GPSM3	35,40	RGS5	GPSM3	54294(Tax:10116)	406163(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of RGS5 GAP activity by GPSM3 .
22130514	0	RGS5	36,40	Regulator_of_G-protein_signaling_5	0,34	RGS5	Regulator of G-protein signaling 5	8490	8490	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Regulator_of_G-protein_signaling_5 -LRB- RGS5 -RRB- protein : a novel marker of cancer vasculature elicited and sustained by the tumor 's proangiogenic microenvironment .
15095478	0	RGS5	59,63	regulator_of_G_protein_signalling_protein_5	14,57	RGS5	regulator of G protein signalling protein 5	8490	8490	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of regulator_of_G_protein_signalling_protein_5 -LRB- RGS5 -RRB- in the tumour vasculature of human renal_cell_carcinoma .
14734556	0	RGS6	0,4	DMAP1	20,25	RGS6	DMAP1	9628	55929	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity .
12761220	0	RGS6	102,106	RGS	117,120	RGS6	RGS	9628	5308	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins .
22179605	0	RGS6	36,40	Regulator_of_G_protein_signaling_6	0,34	RGS6	Regulator of G protein signaling 6	9628	9628	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Regulator_of_G_protein_signaling_6 -LRB- RGS6 -RRB- protein ensures coordination of motor movement by modulating GABAB receptor signaling .
12140291	0	RGS6	0,4	SCG10	20,25	RGS6	SCG10	54295(Tax:10116)	84510(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RGS6 interacts with SCG10 and promotes neuronal differentiation .
18760349	0	RGS8	68,72	melanin-concentrating_hormone_receptor_1	14,54	RGS8	melanin-concentrating hormone receptor 1	85397	2847	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of melanin-concentrating_hormone_receptor_1 signaling by RGS8 with the receptor third intracellular loop .
12880183	0	RGS8	52,56	regulator_of_G_protein_signaling_8	16,50	RGS8	regulator of G protein signaling 8	54297(Tax:10116)	54297(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Distribution of regulator_of_G_protein_signaling_8 -LRB- RGS8 -RRB- protein in the cerebellum .
15728856	0	RGS9	87,91	RGS9-2	71,77	RGS9	RGS9-2	19739(Tax:10090)	19739(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	D2 dopamine receptors colocalize regulator_of_G-protein_signaling_9-2 -LRB- RGS9-2 -RRB- via the RGS9 DEP domain , and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways .
15728856	0	RGS9-2	71,77	RGS9	87,91	RGS9-2	RGS9	19739(Tax:10090)	19739(Tax:10090)	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	D2 dopamine receptors colocalize regulator_of_G-protein_signaling_9-2 -LRB- RGS9-2 -RRB- via the RGS9 DEP domain , and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways .
21616123	0	RGS9-2	38,44	Regulator_of_G_protein_signaling_9-2	0,36	RGS9-2	Regulator of G protein signaling 9-2	19739(Tax:10090)	19739(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Regulator_of_G_protein_signaling_9-2 -LRB- RGS9-2 -RRB- mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells .
24327964	0	RGS9-2	31,37	TrkB	12,16	RGS9-2	TrkB	19739(Tax:10090)	18212(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity .
17126529	0	RGSZ1	0,5	PKCI-1	58,64	RGSZ1	PKCI-1	8601	3094	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	RGSZ1 interacts with protein_kinase_C_interacting_protein PKCI-1 and modulates mu opioid receptor signaling .
21478367	0	RHA2a	65,70	RHA2b	38,43	RHA2a	RHA2b	838073(Tax:3702)	814644(Tax:3702)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic_acid signaling and drought response .
21478367	0	RHA2b	38,43	RHA2a	65,70	RHA2b	RHA2a	814644(Tax:3702)	838073(Tax:3702)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The Arabidopsis RING finger E3 ligase RHA2b acts additively with RHA2a in regulating abscisic_acid signaling and drought response .
8666924	0	RHAMM	28,33	Cdc2	72,76	RHAMM	Cdc2	3161	983	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Soluble hyaluronan receptor RHAMM induces mitotic_arrest by suppressing Cdc2 and cyclin_B1 expression .
25731190	0	RHAMM	48,53	Receptor_for_hyaluronic_acid-mediated_motility	0,46	RHAMM	Receptor for hyaluronic acid-mediated motility	3161	3161	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Receptor_for_hyaluronic_acid-mediated_motility -LRB- RHAMM , CD168 -RRB- expression is prognostically important in both nodal negative and nodal positive large cell lung_cancer .
24367099	0	RHAMM	53,58	YAP	77,80	RHAMM	YAP	3161	10413	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast_cancer cell motility .
9556628	0	RHAMM	24,29	extracellular-regulated_kinase	40,70	RHAMM	extracellular-regulated kinase	3161	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	The hyaluronan receptor RHAMM regulates extracellular-regulated_kinase .
16604446	0	RHAMM	67,72	hyaluronan-mediated_motility_receptor	28,65	RHAMM	hyaluronan-mediated motility receptor	3161	3161	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A gene similar to the human hyaluronan-mediated_motility_receptor -LRB- RHAMM -RRB- gene is upregulated during Porcine_Circovirus_type_2 infection .
23382057	0	RHAMM	57,62	receptor_for_hyaluronan-mediated_motility	14,55	RHAMM	receptor for hyaluronan-mediated motility	3161	3161	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of receptor_for_hyaluronan-mediated_motility -LRB- RHAMM -RRB- in ossifying fibromas .
24676428	0	RHAMM	51,56	receptor_for_hyaluronan-mediated_motility	8,49	RHAMM	receptor for hyaluronan-mediated motility	3161	3161	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of receptor_for_hyaluronan-mediated_motility -LRB- RHAMM -RRB- in human head_and_neck_cancers .
25359212	0	RHGF-1	0,6	DLK-1	33,38	RHGF-1	DLK-1	184419(Tax:6239)	173128(Tax:6239)	Gene	Gene	START_ENTITY|appos|signaling signaling|nsubj|END_ENTITY	RHGF-1 / PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly .
26188247	0	RHGF-2	32,38	LET-502	75,82	RHGF-2	LET-502	173748(Tax:6239)	172088(Tax:6239)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. _ elegans .
26188247	0	RHGF-2	32,38	LET-502	75,82	RHGF-2	LET-502	173748(Tax:6239)	172088(Tax:6239)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The Rho guanine exchange factor RHGF-2 acts through the Rho-binding kinase LET-502 to mediate embryonic elongation in C. _ elegans .
9545237	0	RHO1	30,34	ROM2	68,72	RHO1	ROM2	856294(Tax:4932)	851086(Tax:4932)	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Cell wall integrity modulates RHO1 activity via the exchange factor ROM2 .
26103434	0	RHOA	5,9	RHOA	43,47	RHOA	RHOA	387	387	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|END_ENTITY	G17V RHOA : Genetic evidence of GTP-unbound RHOA playing a role in tumorigenesis in T cells .
23317270	0	RHOXF1	15,21	BCL2	57,61	RHOXF1	BCL2	158800	596	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	shRNA mediated RHOXF1 silencing influences expression of BCL2 but not CASP8 in MCF-7 and MDA-MB-231 cell lines .
16757337	0	RIAM	19,23	Rap1	0,4	RIAM	Rap1	54518	54386	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Rap1 regulation of RIAM and cell adhesion .
17403904	0	RIAM	0,4	Rap1	48,52	RIAM	Rap1	54518	5906	Gene	Gene	links|nsubj|START_ENTITY links|dobj|ADAP/SKAP ADAP/SKAP|acl|signaling signaling|nmod|END_ENTITY	RIAM links the ADAP/SKAP -55 signaling module to Rap1 , facilitating T-cell-receptor-mediated integrin activation .
24287201	0	RIAM	38,42	Rap1	17,21	RIAM	Rap1	54518	5906	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism .
21454517	0	RIAM	39,43	Rap1-GTP-interacting_adaptor_molecule	0,37	RIAM	Rap1-GTP-interacting adaptor molecule	54518	54518	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Rap1-GTP-interacting_adaptor_molecule -LRB- RIAM -RRB- protein controls invasion and growth of melanoma cells .
19223395	0	RIC-3	44,49	BATH-42	21,28	RIC-3	BATH-42	177570(Tax:6239)	176152(Tax:6239)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The BTB-MATH protein BATH-42 interacts with RIC-3 to regulate maturation of nicotinic acetylcholine receptors .
9575181	0	RICK	0,4	CLARP	85,90	RICK	CLARP	8767	8837	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RICK , a novel protein kinase containing a caspase recruitment domain , interacts with CLARP and regulates CD95-mediated apoptosis .
12531901	0	RICS	0,4	Cdc42	44,49	RICS	Cdc42	9743	998	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	RICS , a novel GTPase-activating protein for Cdc42 and Rac1 , is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling .
20116405	0	RICTOR	15,21	insulin-like_growth_factor-I_receptor	66,103	mTORC1	insulin-like growth factor-I receptor	382056(Tax:10090)	3480	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- and human epidermal_growth_factor_receptor-2 -LRB- Her2 -RRB- expression in gastrointestinal_cancer cells .
21233210	0	RIG-I	37,42	ARF-like_protein_16	0,19	RIG-I	ARF-like protein 16	23586	339231	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	ARF-like_protein_16 -LRB- ARL16 -RRB- inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner .
24701034	0	RIG-I	64,69	CXCL10	32,38	RIG-I	CXCL10	23586	3627	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Hantaan_virus_infection induces CXCL10 expression through TLR3 , RIG-I , and MDA-5 pathways correlated with the disease severity .
24651521	0	RIG-I	15,20	DHX36	0,5	RIG-I	DHX36	23586	170506	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation .
23707530	0	RIG-I	62,67	IFN-b	77,82	RIG-I	IFN-b	23586	3456	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Inducible_cAMP_early_repressor -LRB- ICER -RRB- is a novel regulator of RIG-I mediated IFN-b production .
17460044	0	RIG-I	27,32	RNF125	67,73	RIG-I	RNF125	23586	54941	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 .
17719635	0	RIG-I	51,56	UbcH8	0,5	RIG-I	UbcH8	23586	9246	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I .
19164550	0	RIG-I	14,19	gC1qR	61,66	RIG-I	gC1qR	23586	708	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria .
17182220	0	RIG-I	55,60	retinoic_acid-inducible_gene-I	23,53	RIG-I	retinoic acid-inducible gene-I	23586	23586	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Cytokine modulation of retinoic_acid-inducible_gene-I -LRB- RIG-I -RRB- expression in human epidermal keratinocytes .
22391244	0	RIG-I	52,57	retinoic_acid-inducible_gene-I	20,50	RIG-I	retinoic acid-inducible gene-I	23586	23586	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Characterization of retinoic_acid-inducible_gene-I -LRB- RIG-I -RRB- expression corresponding to viral_infection and UVB in human keratinocytes .
22328336	0	RIG-I-like_receptor	29,48	Ankrd17	0,7	RIG-I-like receptor	Ankrd17	79132	26057	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Ankrd17 positively regulates RIG-I-like_receptor -LRB- RLR -RRB- - mediated immune signaling .
8344391	0	RIHB	46,50	Retinoic_acid-induced_heparin-binding_factor	0,44	RIHB	Retinoic acid-induced heparin-binding factor	423196(Tax:9031)	423196(Tax:9031)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Retinoic_acid-induced_heparin-binding_factor -LRB- RIHB -RRB- mRNA and protein are strongly induced in chick embryo chondrocytes treated with retinoic_acid .
7925417	0	RIHB	81,85	retinoic-acid-induced-heparin-binding	42,79	RIHB	retinoic-acid-induced-heparin-binding	423196(Tax:9031)	423196(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Organisation and promoter activity of the retinoic-acid-induced-heparin-binding -LRB- RIHB -RRB- gene .
17332327	0	RIL	0,3	LIM	7,10	RIL	LIM	8572	10611	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	RIL , a LIM gene on 5q31 , is silenced by methylation in cancer and sensitizes cancer cells to apoptosis .
19293990	0	RIL	47,50	reversion-induced_LIM_protein	16,45	RIL	reversion-induced LIM protein	24915(Tax:10116)	24915(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of reversion-induced_LIM_protein -LRB- RIL -RRB- in the rat central nervous system .
15933719	0	RILP	36,40	Rab7	57,61	RILP	Rab7	83547	338382	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recruitment of RILP by small GTPase Rab7 .
16857164	0	RILP	0,4	VPS22	24,29	RILP	VPS22	83547	11267	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|component component|compound|END_ENTITY	RILP interacts with the VPS22 component of the ESCRT-II complex .
17010938	0	RILP	0,4	VPS22	20,25	RILP	VPS22	83547	11267	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment .
12163476	0	RIM1	105,109	Cast	0,4	RIM1	Cast	84556(Tax:10116)	292657(Tax:10116)	Gene	Gene	forms|nmod|START_ENTITY protein|acl:relcl|forms END_ENTITY|dep|protein	Cast : a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1 .
11784866	0	RIN1	17,21	RAF	45,48	RIN1	RAF	9610	22882	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins .
11703925	0	RIN1	90,94	Rab5	45,49	RIN1	Rab5	9610	5868	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Ras-activated endocytosis is mediated by the Rab5 guanine_nucleotide exchange activity of RIN1 .
11231087	0	RIN1	60,64	sprint	26,32	RIN1	sprint	31987(Tax:7227)	31987(Tax:7227)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Cloning and expression of sprint , a Drosophila homologue of RIN1 .
17012600	0	RIN4	22,26	NDR1	0,4	RIN4	NDR1	822098(Tax:3702)	821607(Tax:3702)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	NDR1 interaction with RIN4 mediates the differential activation of multiple disease resistance pathways in Arabidopsis .
19182210	0	RINF	26,30	CXXC5	67,72	RINF	CXXC5	51523	51523	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Functional involvement of RINF , retinoid-inducible_nuclear_factor -LRB- CXXC5 -RRB- , in normal and tumoral human myelopoiesis .
7907993	0	RING12	83,89	LMP2	77,81	RING12	LMP2	5698	5698	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	PRE3 , highly homologous to the human major histocompatibility complex-linked LMP2 -LRB- RING12 -RRB- gene , codes for a yeast proteasome subunit necessary for the peptidylglutamyl-peptide hydrolyzing activity .
20697353	0	RING1b	13,19	Id1	0,3	RING1b	Id1	6045	3397	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18 / Bmi-1 polycomb group complex .
11461916	0	RINGO	44,49	Cdc2	27,31	RINGO	Cdc2	398012(Tax:8355)	379785(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of Cdc2 and Cdk2 by RINGO and cyclins .
24292229	0	RING_box_protein-1	21,39	RBX1	41,45	RING box protein-1	RBX1	9978	9978	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Prognostic impact of RING_box_protein-1 -LRB- RBX1 -RRB- expression in gastric_cancer .
19528490	0	RING_finger_protein11	4,25	Smad4	35,40	RING finger protein11	Smad4	26994	4089	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The RING_finger_protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling .
18724389	0	RING_finger_protein_11	90,112	WW_domain_containing_E3_ubiquitin_protein_ligase_1	4,54	RING finger protein 11	WW domain containing E3 ubiquitin protein ligase 1	26994	11059	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|nsubj|END_ENTITY	The WW_domain_containing_E3_ubiquitin_protein_ligase_1 upregulates ErbB2 and EGFR through RING_finger_protein_11 .
24466159	0	RING_finger_protein_43	63,85	RNF43	87,92	RING finger protein 43	RNF43	54894	54894	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of two Wnt-responsive elements in the intron of RING_finger_protein_43 -LRB- RNF43 -RRB- gene .
16571679	0	RINT-1	0,6	ZW10	47,51	RINT-1	ZW10	60561	9183	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	RINT-1 regulates the localization and entry of ZW10 to the syntaxin_18 complex .
10755617	0	RIP	60,63	NEMO	80,84	RIP	NEMO	8737	8517	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	Recruitment of the IKK signalosome to the p55 TNF receptor : RIP and A20 bind to NEMO -LRB- IKKgamma -RRB- upon receptor stimulation .
10409763	0	RIP	164,167	TRADD	124,129	RIP	TRADD	8737	8717	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	The Epstein-Barr_virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting_protein -LRB- RIP -RRB- but does not induce apoptosis or require RIP for NF-kappaB activation .
10958661	0	RIP	24,27	TRAIL	45,50	RIP	TRAIL	8737	8743	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	The death domain kinase RIP is essential for TRAIL -LRB- Apo2L -RRB- - induced activation of IkappaB kinase and c-Jun_N-terminal_kinase .
23356698	0	RIP-2	60,65	caspase-1	66,75	RIP-2	caspase-1	192656(Tax:10090)	12362(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Saengmaeksan inhibits inflammatory mediators by suppressing RIP-2 / caspase-1 activation .
22580278	0	RIP1	16,20	ARD1	0,4	RIP1	ARD1	8737	8260	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	ARD1 binding to RIP1 mediates doxorubicin-induced NF-kB activation .
23469174	0	RIP1	43,47	Akt	0,3	RIP1	Akt	19766(Tax:10090)	11651(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis .
19641134	0	RIP1	35,39	Fas_ligand	15,25	RIP1	Fas ligand	8737	356	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Membrane-bound Fas_ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex .
16597320	0	RIP1	50,54	JNK	80,83	RIP1	JNK	734234(Tax:8355)	379876(Tax:8355)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Xenopus death-domain-containing proteins FADD and RIP1 synergistically activate JNK and NF-kappaB .
15064760	0	RIP1	0,4	NF-kappa_B	62,72	RIP1	NF-kappa B	19766(Tax:10090)	18033(Tax:10090)	Gene	Gene	mediator|nsubj|START_ENTITY mediator|nmod|activation activation|compound|END_ENTITY	RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa_B activation .
24113711	0	RIP1	17,21	Pellino3	0,8	RIP1	Pellino3	19766(Tax:10090)	240518(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-a .
24113711	0	RIP1	17,21	TNF-a	65,70	RIP1	TNF-a	19766(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|dobj|effects effects|nmod|END_ENTITY	Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-a .
23469174	0	RIP1	43,47	TNFa	14,18	RIP1	TNFa	19766(Tax:10090)	21926(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis .
25939870	0	RIP1	17,21	XIAP	41,45	RIP1	XIAP	8737	331	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly .
19641134	0	RIP1	35,39	caspase-8	68,77	RIP1	caspase-8	8737	841	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Membrane-bound Fas_ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex .
22585859	0	RIP1	52,56	caspase-8	66,75	RIP1	caspase-8	8737	841	Gene	Gene	polyubiquitination|nmod|START_ENTITY inhibits|nsubj|polyubiquitination inhibits|dobj|apoptosis apoptosis|amod|END_ENTITY	A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma .
18566599	0	RIP1	35,39	p27	50,53	RIP1	p27	19766(Tax:10090)	12576(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	The death domain-containing kinase RIP1 regulates p27 -LRB- Kip1 -RRB- levels through the PI3K-Akt-forkhead pathway .
14585994	0	RIP1	24,28	tumor_necrosis_factor_alpha	46,73	RIP1	tumor necrosis factor alpha	19766(Tax:10090)	21926(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	The death domain kinase RIP1 is essential for tumor_necrosis_factor_alpha signaling to p38 mitogen-activated protein kinase .
22209746	0	RIP140	50,56	Endothelin-1	0,12	RIP140	Endothelin-1	268903(Tax:10090)	13614(Tax:10090)	Gene	Gene	accumulation|nmod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	Endothelin-1 promotes cytoplasmic accumulation of RIP140 through a ET -LRB- A -RRB- - PLCb-PKC pathway .
17389641	0	RIP140	159,165	TR2	24,27	RIP140	TR2	8204	7181	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Orphan nuclear receptor TR2 , a mediator of preadipocyte proliferation , is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1 .
9774688	0	RIP140	38,44	TR2	88,91	RIP140	TR2	268903(Tax:10090)	22025(Tax:10090)	Gene	Gene	START_ENTITY|appos|corepressor corepressor|nmod|END_ENTITY	Cloning and characterization of mouse RIP140 , a corepressor for nuclear orphan receptor TR2 .
19780716	0	RIP140	89,95	receptor-interacting_protein_140	55,87	RIP140	receptor-interacting protein 140	268903(Tax:10090)	268903(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	MicroRNA mir-346 targets the 5 ' - untranslated region of receptor-interacting_protein_140 -LRB- RIP140 -RRB- mRNA and up-regulates its protein expression .
9521594	0	RIP140	50,56	receptor_interacting_protein_140	16,48	RIP140	receptor interacting protein 140	8204	8204	Gene	Gene	Localisation|appos|START_ENTITY Localisation|nmod|END_ENTITY	Localisation of receptor_interacting_protein_140 -LRB- RIP140 -RRB- within 100 kb of D21S13 on 21q11 , a gene-poor region of the human genome .
18775659	0	RIP2	17,21	MEKK4	0,5	RIP2	MEKK4	8767	4216	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	MEKK4 sequesters RIP2 to dictate NOD2 signal specificity .
19667203	0	RIP2	49,53	XIAP	0,4	RIP2	XIAP	8767	331	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	XIAP mediates NOD signaling via interaction with RIP2 .
22815893	0	RIP2	114,118	XIAP	104,108	RIP2	XIAP	8767	331	Gene	Gene	disturbing|nmod|START_ENTITY disturbing|dobj|interaction interaction|nmod|END_ENTITY	The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-kB activation by disturbing the interaction of XIAP with RIP2 .
17578844	0	RIP2	0,4	p38	26,29	RIP2	p38	8767	1432	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	RIP2 mediates LPS-induced p38 and IkappaBalpha signaling including IL-12 p40 expression in human monocyte-derived dendritic cells .
24703947	0	RIP3	106,110	MLKL	41,45	RIP3	MLKL	11035	197259	Gene	Gene	causes|nmod|START_ENTITY causes|nsubj|END_ENTITY	Mixed_lineage_kinase_domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3 .
12446564	0	RIP4	0,4	NF-kappa_B	67,77	RIP4	NF-kappa B	54101	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	RIP4 -LRB- DIK/PKK -RRB- , a novel member of the RIP kinase family , activates NF-kappa_B and is processed during apoptosis .
26877205	0	RIPK1	8,13	TNFR1	40,45	RIPK1	TNFR1	8737	7132	Gene	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling .
21339290	0	RIPK1	25,30	TRAF2	69,74	RIPK1	TRAF2	8737	7186	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	In TNF-stimulated cells , RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1 , which limits induction of non-canonical NF-kappaB and activation of caspase-8 .
26826208	0	RIPK1	25,30	TRAF2	69,74	RIPK1	TRAF2	8737	7186	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	In TNF-stimulated cells , RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1 , which limits induction of non-canonical NF-kB and activation of caspase-8 .
19716330	0	RISC	16,20	CAF1	30,34	RISC	CAF1	59342	8208	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation .
23895878	0	RISC	35,39	RNA_helicase_A	0,14	RISC	RNA helicase A	59342	1660	Gene	Gene	activity|compound|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	RNA_helicase_A is not required for RISC activity .
15558054	0	RITA	15,19	p53	29,32	RITA	p53	55422	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Small molecule RITA binds to p53 , blocks p53-HDM-2 interaction and activates p53 function in tumors .
20395210	0	RITA	41,45	p53	10,13	RITA	p53	84934	7157	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Rescue Rescue|nmod|END_ENTITY	Rescue of p53 function by small-molecule RITA in cervical_carcinoma by blocking E6-mediated degradation .
20436301	0	RITA	74,78	p53	52,55	RITA	p53	55422	7157	Gene	Gene	Rescue|nmod|START_ENTITY Rescue|nmod|function function|nmod|END_ENTITY	Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA .
22276160	0	RITA	47,51	p53	10,13	RITA	p53	84934	7157	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Targeting p53 via JNK pathway : a novel role of RITA for apoptotic signaling in multiple_myeloma .
22476102	0	RITA	72,76	p53	124,127	RITA	p53	55422	7157	Gene	Gene	resistance|nmod|START_ENTITY cells|nmod|resistance retain|nsubj|cells retain|nmod|agents agents|compound|END_ENTITY	Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents .
22476102	0	RITA	72,76	p53	95,98	RITA	p53	55422	7157	Gene	Gene	resistance|nmod|START_ENTITY cells|nmod|resistance retain|nsubj|cells retain|dobj|END_ENTITY	Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents .
23864164	0	RITA	61,65	p53	39,42	RITA	p53	55422	7157	Gene	Gene	Dual|nmod|START_ENTITY Dual|nmod|END_ENTITY	Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro .
24308154	10	RITA	1206,1210	p53	1238,1241	RITA	p53	84934	7157	Gene	Gene	overexpression|compound|START_ENTITY upregulated|nsubj|overexpression upregulated|dobj|levels levels|compound|END_ENTITY	RITA overexpression upregulated p53 and reduced cyclin E levels , whereas silencing of RITA had the opposite effect on p53 and cyclin E expression .
24345738	0	RITA	41,45	p53	29,32	RITA	p53	84934	7157	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural_mesothelioma .
24927749	0	RITA	0,4	p53	122,125	RITA	p53	84934	7157	Gene	Gene	efficient|nsubj|START_ENTITY efficient|nmod|pathway pathway|compound|END_ENTITY	RITA -LRB- Reactivating p53_and_Inducing_Tumor_Apoptosis -RRB- is efficient against TP53abnormal myeloma cells independently of the p53 pathway .
25010984	0	RITA	0,4	p53	67,70	RITA	p53	55422	7157	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|cells cells|nmod|function function|compound|END_ENTITY	RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38 .
10862032	0	RIZ	119,122	PRDM2	124,129	RIZ	PRDM2	7799	7799	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping of a minimal deleted region in human hepatocellular_carcinoma to 1p36.13-p36 .23 and mutational analysis of the RIZ -LRB- PRDM2 -RRB- gene localized to the region .
11135439	0	RIZ	0,3	retinoblastoma_protein_interacting_zinc_finger	9,55	RIZ	retinoblastoma protein interacting zinc finger	7799	7799	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	RIZ , the retinoblastoma_protein_interacting_zinc_finger gene , is mutated in genetically unstable cancers of the pancreas , stomach , and colorectum .
26622888	0	RIZ1	69,73	GSTP1	57,62	RIZ1	GSTP1	7799	2950	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Detecting abnormal methylation of tumor suppressor genes GSTP1 , P16 , RIZ1 , and RASSF1A in hepatocellular_carcinoma and its clinical significance .
26622888	0	RIZ1	69,73	P16	64,67	RIZ1	P16	7799	1029	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Detecting abnormal methylation of tumor suppressor genes GSTP1 , P16 , RIZ1 , and RASSF1A in hepatocellular_carcinoma and its clinical significance .
15711769	0	RIZ1	62,66	Patched-2	51,60	RIZ1	Patched-2	7799	8643	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Mutational study of the 1p located genes p18ink4c , Patched-2 , RIZ1 and KIF1B in oligodendrogliomas .
15711769	0	RIZ1	62,66	p18ink4c	41,49	RIZ1	p18ink4c	7799	1031	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Mutational study of the 1p located genes p18ink4c , Patched-2 , RIZ1 and KIF1B in oligodendrogliomas .
11280725	0	RIZ1	22,26	tumor_suppressor	30,46	RIZ1	tumor suppressor	7799	7248	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Adenovirus expressing RIZ1 in tumor_suppressor gene therapy of microsatellite-unstable colorectal_cancers .
26375811	0	RKIP	0,4	CCL5	15,19	RKIP	CCL5	5037	6352	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	RKIP regulates CCL5 expression to inhibit breast_cancer invasion and metastasis by controlling macrophage infiltration .
20043910	0	RKIP	0,4	NF-kappaB	14,23	RKIP	NF-kappaB	5037	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex .
18294816	0	RKIP	4,8	Raf-1	10,15	RKIP	Raf-1	5037	5894	Gene	Gene	START_ENTITY|appos|Protein Protein|compound|END_ENTITY	The RKIP -LRB- Raf-1 Kinase Inhibitor Protein -RRB- conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK .
22610096	0	RKIP	30,34	Raf1	84,88	RKIP	Raf1	23980(Tax:10090)	110157(Tax:10090)	Gene	Gene	Raf_kinase_inhibitor_protein|appos|START_ENTITY dimer|nsubj|Raf_kinase_inhibitor_protein dimer|ccomp|controls controls|nmod|END_ENTITY	Raf_kinase_inhibitor_protein -LRB- RKIP -RRB- dimer formation controls its target switch from Raf1 to G_protein-coupled_receptor_kinase _ -LRB- GRK -RRB- _ 2 .
24863296	0	RKIP	21,25	Raf1	53,57	RKIP	Raf1	5037	5894	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Structural basis for RKIP binding with its substrate Raf1 kinase .
24763848	0	RKIP	44,48	Raf_Kinase_Inhibitor_Protein	14,42	RKIP	Raf Kinase Inhibitor Protein	5037	5037	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Raf_Kinase_Inhibitor_Protein -LRB- RKIP -RRB- is a predictor of uveal_melanoma metastasis .
15313400	0	RKIP	42,46	Raf_kinase_inhibitor_protein	12,40	RKIP	Raf kinase inhibitor protein	23980(Tax:10090)	23980(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of Raf_kinase_inhibitor_protein -LRB- RKIP -RRB- in health and disease .
25128483	0	RKIP	67,71	miR-27a	0,7	RKIP	miR-27a	5037	407018	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung_adenocarcinoma cells .
23814485	0	RKIP	23,27	p53	6,9	RKIP	p53	5037	7157	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new p53 target gene , RKIP , is essential for DNA damage-induced cellular senescence and suppression of ERK activation .
18515281	0	RKTG	0,4	B-Raf	16,21	RKTG	B-Raf	152559	673	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant_melanoma cells .
10102298	0	RLBP1	90,95	cellular_retinaldehyde-binding_protein	45,83	RLBP1	cellular retinaldehyde-binding protein	6017	6017	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Bothnia_dystrophy caused by mutations in the cellular_retinaldehyde-binding_protein gene -LRB- RLBP1 -RRB- on chromosome 15q26 .
15234312	0	RLBP1	91,96	cellular_retinaldehyde-binding_protein	46,84	RLBP1	cellular retinaldehyde-binding protein	6017	6017	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel compound heterozygous mutation in the cellular_retinaldehyde-binding_protein gene -LRB- RLBP1 -RRB- in a patient with retinitis_punctata_albescens .
24640564	0	RLF	31,34	RXFP2	51,56	RLF	RXFP2	6018	122042	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression and localization of RLF / INSL3 receptor RXFP2 in boar testes .
21899516	0	RLF	21,24	insulin-like_peptide_3	26,48	RLF	insulin-like peptide 3	6018	3640	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Relaxin-like factor -LRB- RLF -RRB- / insulin-like_peptide_3 -LRB- INSL3 -RRB- is secreted from testicular Leydig cells as a monomeric protein comprising three domains B-C-A with full biological activity in boars .
10542371	0	RLF	57,60	relaxin-like_factor	36,55	RLF	relaxin-like factor	114215(Tax:10116)	114215(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and expression of the rat relaxin-like_factor -LRB- RLF -RRB- gene .
10759163	0	RLF	56,59	relaxin-like_factor	35,54	RLF	relaxin-like factor	6018	6018	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common polymorphism in the human relaxin-like_factor -LRB- RLF -RRB- gene : no relationship with cryptorchidism .
9660177	0	RLI	19,22	RNase_L	0,7	RLI	RNase L	6059	6041	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	RNase_L inhibitor -LRB- RLI -RRB- antisense constructions block partially the down regulation of the 2-5A / RNase_L pathway in encephalomyocarditis-virus - -LRB- EMCV -RRB- - infected cells .
9660177	0	RLI	19,22	RNase_L	96,103	RLI	RNase L	6059	6041	Gene	Gene	inhibitor|appos|START_ENTITY antisense|nsubj|inhibitor antisense|dep|block block|dobj|regulation regulation|nmod|2-5A 2-5A|dep|pathway pathway|amod|END_ENTITY	RNase_L inhibitor -LRB- RLI -RRB- antisense constructions block partially the down regulation of the 2-5A / RNase_L pathway in encephalomyocarditis-virus - -LRB- EMCV -RRB- - infected cells .
21945933	0	RLIM	0,4	Smurf2	20,26	RLIM	Smurf2	51132	64750	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RLIM interacts with Smurf2 and promotes TGF-b induced U2OS cell migration .
15511640	0	RLIP	0,4	RalB	41,45	RLIP	RalB	394288(Tax:8355)	399470(Tax:8355)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	RLIP mediates downstream signalling from RalB to the actin cytoskeleton during Xenopus early development .
24928198	0	RLIP76	0,6	HIF-1	17,22	RLIP76	HIF-1	10928	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	RLIP76 regulates HIF-1 activity , VEGF expression and secretion in tumor cells , and secretome transactivation of endothelial cells .
23419874	0	RLIP76	25,31	P300	0,4	RLIP76	P300	10928	2033	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	P300 regulates the human RLIP76 promoter activity and gene expression .
17031460	0	RLK	125,128	receptor-like_kinase	99,119	RLK	receptor-like kinase	836863(Tax:3702)	836863(Tax:3702)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Domain-specific positive selection contributes to the evolution of Arabidopsis leucine-rich repeat receptor-like_kinase -LRB- LRR RLK -RRB- genes .
16477135	0	RLK	84,87	receptor-like_kinase_gene	57,82	RLK	receptor-like kinase gene	100286391(Tax:4565)	100286391(Tax:4565)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Cloning , characterization and expression analysis of the receptor-like_kinase_gene -LRB- RLK -RRB- in common_wheat .
15895077	0	RME-6	23,28	RAB-5	53,58	RME-6	RAB-5	180463(Tax:6239)	172755(Tax:6239)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Caenorhabditis_elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit .
14608646	0	RMRP	0,4	cartilage-hair_hypoplasia	41,66	RMRP	cartilage-hair hypoplasia	6023	6023	Gene	Gene	mutations|nsubj|START_ENTITY mutations|nmod|END_ENTITY	RMRP mutations in Japanese patients with cartilage-hair_hypoplasia .
23932716	0	RMST	23,27	SOX2	43,47	RMST	SOX2	196475	6657	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis .
20977548	0	RNA-binding_motif_protein_24	0,28	myogenin	39,47	RNA-binding motif protein 24	myogenin	666794(Tax:10090)	17928(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	RNA-binding_motif_protein_24 regulates myogenin expression and promotes myogenic differentiation .
12824175	0	RNA-binding_motif_protein_3	61,88	Rbm3	90,94	RNA-binding motif protein 3	Rbm3	5935	5935	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	The internal ribosome entry site -LRB- IRES -RRB- contained within the RNA-binding_motif_protein_3 -LRB- Rbm3 -RRB- mRNA is composed of functionally distinct elements .
26923328	0	RNA-binding_motif_protein_47	0,28	Nrf2	38,42	RNA-binding motif protein 47	Nrf2	245945(Tax:10090)	18024(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	RNA-binding_motif_protein_47 inhibits Nrf2 activity to suppress tumor growth in lung_adenocarcinoma .
8325883	0	RNA-binding_protein	3,22	RBP1	29,33	RNA-binding protein	RBP1	855587(Tax:4932)	855587(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An RNA-binding_protein gene -LRB- RBP1 -RRB- of Saccharomyces_cerevisiae encodes a putative glucose-repressible protein containing two RNA recognition motifs .
17375189	0	RNA-helicase	21,33	MLN51	0,5	RNA-helicase	MLN51	55308	22794	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	MLN51 stimulates the RNA-helicase activity of eIF4AIII .
17375189	0	RNA-helicase	21,33	eIF4AIII	46,54	RNA-helicase	eIF4AIII	55308	9775	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	MLN51 stimulates the RNA-helicase activity of eIF4AIII .
2154681	0	RNA4	10,14	PRP4	4,8	RNA4	PRP4	856307(Tax:4932)	856307(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The PRP4 -LRB- RNA4 -RRB- protein of Saccharomyces_cerevisiae is associated with the 5 ' portion of the U4 small nuclear RNA .
24183309	0	RNASEH2A	111,119	RNASEH2B	121,129	RNASEH2A	RNASEH2B	10535	79621	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
24183309	0	RNASEH2A	111,119	RNASEH2B	121,129	RNASEH2A	RNASEH2B	10535	79621	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
25604658	0	RNASEH2A	81,89	RNASEH2B	91,99	RNASEH2A	RNASEH2B	10535	79621	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
24183309	0	RNASEH2A	111,119	RNASEH2C	131,139	RNASEH2A	RNASEH2C	10535	84153	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
24183309	0	RNASEH2A	111,119	RNASEH2C	131,139	RNASEH2A	RNASEH2C	10535	84153	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
25604658	0	RNASEH2A	81,89	RNASEH2C	101,109	RNASEH2A	RNASEH2C	10535	84153	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
25604658	0	RNASEH2A	81,89	SAMHD1	111,117	RNASEH2A	SAMHD1	10535	25939	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
24183309	0	RNASEH2B	121,129	RNASEH2A	111,119	RNASEH2B	RNASEH2A	79621	10535	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
24183309	0	RNASEH2B	121,129	RNASEH2A	111,119	RNASEH2B	RNASEH2A	79621	10535	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
25604658	0	RNASEH2B	91,99	RNASEH2A	81,89	RNASEH2B	RNASEH2A	79621	10535	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
24183309	0	RNASEH2B	121,129	RNASEH2C	131,139	RNASEH2B	RNASEH2C	79621	84153	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
24183309	0	RNASEH2B	121,129	RNASEH2C	131,139	RNASEH2B	RNASEH2C	79621	84153	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
25604658	0	RNASEH2B	91,99	RNASEH2C	101,109	RNASEH2B	RNASEH2C	79621	84153	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
25604658	0	RNASEH2B	91,99	SAMHD1	111,117	RNASEH2B	SAMHD1	79621	25939	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
24183309	0	RNASEH2C	131,139	RNASEH2A	111,119	RNASEH2C	RNASEH2A	84153	10535	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
24183309	0	RNASEH2C	131,139	RNASEH2A	111,119	RNASEH2C	RNASEH2A	84153	10535	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
25604658	0	RNASEH2C	101,109	RNASEH2A	81,89	RNASEH2C	RNASEH2A	84153	10535	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
24183309	0	RNASEH2C	131,139	RNASEH2B	121,129	RNASEH2C	RNASEH2B	84153	79621	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
24183309	0	RNASEH2C	131,139	RNASEH2B	121,129	RNASEH2C	RNASEH2B	84153	79621	Gene	Gene	SAMHD1|appos|START_ENTITY SAMHD1|appos|END_ENTITY	Assessment of interferon-related biomarkers in Aicardi-Gouti __ res_syndrome associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , and ADAR : a case-control study .
25604658	0	RNASEH2C	101,109	RNASEH2B	91,99	RNASEH2C	RNASEH2B	84153	79621	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
25604658	0	RNASEH2C	101,109	SAMHD1	111,117	RNASEH2C	SAMHD1	84153	25939	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
25544695	0	RNA_binding_motif_protein_3	30,57	RBM3	59,63	RNA binding motif protein 3	RBM3	102176209	102176209	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of RNA_binding_motif_protein_3 -LRB- RBM3 -RRB- gene from Pashmina goat .
19170760	0	RNA_binding_motif_protein_42	23,51	hnRNP_K	0,7	RNA binding motif protein 42	hnRNP K	79171	3190	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	hnRNP_K interacts with RNA_binding_motif_protein_42 and functions in the maintenance of cellular ATP level during stress conditions .
12529443	0	RNA_binding_protein	6,25	protein_arginine_N-methyltransferase_1	54,92	RNA binding protein	protein arginine N-methyltransferase 1	5940	3276	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Sam68 RNA_binding_protein is an in vivo substrate for protein_arginine_N-methyltransferase_1 .
23704370	0	RNA_helicase	14,26	Brr2	27,31	RNA helicase	Brr2	9879	23020	Gene	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of RNA_helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8 .
7853509	0	RNA_helicase	39,51	NS3	11,14	RNA helicase	NS3	9879	3845	Gene	Gene	activity|amod|START_ENTITY possesses|dobj|activity possesses|nsubj|END_ENTITY	Pestivirus NS3 -LRB- p80 -RRB- protein possesses RNA_helicase activity .
14704337	0	RNA_helicase_A	77,91	DNA-dependent_protein_kinase	0,28	RNA helicase A	DNA-dependent protein kinase	1660	5591	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	DNA-dependent_protein_kinase -LRB- DNA-PK -RRB- phosphorylates nuclear DNA_helicase_II / RNA_helicase_A and hnRNP proteins in an RNA-dependent manner .
20225158	0	RNA_helicase_A	55,69	DNA_helicase_II	38,53	RNA helicase A	DNA helicase II	1660	7520	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of nuclear DNA_helicase_II -LRB- RNA_helicase_A -RRB- .
11687588	0	RNA_helicase_A	24,38	Nuclear_DNA_helicase_II	0,23	RNA helicase A	Nuclear DNA helicase II	1660	1660	Gene	Gene	binds|nsubj|START_ENTITY END_ENTITY|parataxis|binds	Nuclear_DNA_helicase_II / RNA_helicase_A binds to filamentous actin .
17303075	0	RNA_helicase_A	59,73	Osterix	27,34	RNA helicase A	Osterix	1660	121340	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The transcriptional factor Osterix directly interacts with RNA_helicase_A .
19229320	0	RNA_helicase_A	61,75	PKR	34,37	RNA helicase A	PKR	1660	5610	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	An antiviral response directed by PKR phosphorylation of the RNA_helicase_A .
25062910	0	RNA_helicase_A	67,81	helicase	46,54	RNA helicase A	helicase	1660	164045	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Helicase associated 2 domain is essential for helicase activity of RNA_helicase_A .
15355351	0	RNA_helicase_A	0,14	p65	52,55	RNA helicase A	p65	1660	5970	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RNA_helicase_A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator .
17532615	0	RNA_polymerase_II	57,74	RPB1	76,80	RNA polymerase II	RPB1	5430	5430	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Higher-level phylogeny of Foraminifera inferred from the RNA_polymerase_II -LRB- RPB1 -RRB- gene .
25639305	0	RNA_polymerase_II-associated_protein_2	6,44	Rpb6	107,111	RNA polymerase II-associated protein 2	Rpb6	79871	5435	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human RNA_polymerase_II-associated_protein_2 -LRB- RPAP2 -RRB- interacts directly with the RNA polymerase II subunit Rpb6 and participates in pre-mRNA 3 _ - end formation .
8641287	0	RNA_polymerase_I_associated_factor_53	0,37	UBF	82,85	RNA polymerase I associated factor 53	UBF	64424(Tax:10090)	21429(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	RNA_polymerase_I_associated_factor_53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription .
21115310	0	RNA_polymerase_subunit	60,82	RPO30	84,89	RNA polymerase subunit	RPO30	3707593(Tax:10245)	3707593(Tax:10245)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Use of the Capripoxvirus homologue of Vaccinia_virus 30 kDa RNA_polymerase_subunit -LRB- RPO30 -RRB- gene as a novel diagnostic and genotyping target : development of a classical PCR method to differentiate Goat poxvirus from Sheep poxvirus .
17971306	0	RNAh	30,34	nucleolin	6,15	RNAh	nucleolin	77987(Tax:10090)	17975(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Mouse nucleolin binds to 4.5 S RNAh , a small noncoding RNA .
21994792	0	RNAse_T2	21,29	Tax	69,72	RNAse T2	Tax	8635	1491938(Tax:11908)	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression inhibition|nmod|END_ENTITY	Direct inhibition of RNAse_T2 expression by the HTLV-1 viral protein Tax .
19131965	0	RNF11	42,47	A20	29,32	RNF11	A20	26994	7128	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling .
20676133	0	RNF11	88,93	Ring_finger_protein_11	64,86	RNF11	Ring finger protein 11	26994	26994	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Multiple modification and protein interaction signals drive the Ring_finger_protein_11 -LRB- RNF11 -RRB- E3 ligase to the endosomal compartment .
25165885	0	RNF114	22,28	A20	44,47	RNF114	A20	55905	28935	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-kB activity and T-cell activation .
26926424	0	RNF12	0,5	MDM2	80,84	RNF12	MDM2	51132	4193	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction .
21298085	0	RNF12	0,5	Xist	16,20	RNF12	Xist	51132	7503	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	RNF12 activates Xist and is essential for X chromosome inactivation .
17460044	0	RNF125	67,73	RIG-I	27,32	RNF125	RIG-I	54941	23586	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 .
23026136	0	RNF126	20,26	p21	96,99	RNF126	p21	55658	644914	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation .
17577571	0	RNF151	0,6	dysbindin	62,71	RNF151	dysbindin	67504(Tax:10090)	94245(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RNF151 , a testis-specific_RING_finger_protein , interacts with dysbindin .
25936802	0	RNF152	37,43	mTORC1	65,71	RNF152	mTORC1	220441	382056(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation .
24196443	0	RNF168	17,23	USP3	0,4	RNF168	USP3	165918	9960	Gene	Gene	counteracts|dobj|START_ENTITY counteracts|nsubj|END_ENTITY	USP3 counteracts RNF168 via deubiquitinating H2A and yH2AX at lysine 13 and 15 .
17873902	0	RNF2	26,30	Prohibitin	0,10	RNF2	Prohibitin	6045	5245	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Prohibitin interacts with RNF2 and regulates E2F1 function via dual pathways .
24980959	0	RNF2	0,4	WASH	21,25	RNF2	WASH	6045	653440	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy .
22021426	0	RNF20	67,72	CDC73	21,26	RNF20	CDC73	56254	79577	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination .
23151810	0	RNF213	38,44	SLC26A11	47,55	RNF213	SLC26A11	57674	284129	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of a novel gene fusion RNF213 - SLC26A11 in chronic myeloid_leukemia by RNA-Seq .
22106342	0	RNF4	35,39	Tax	106,109	RNF4	Tax	6047	6900	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax .
21108931	0	RNF43	0,5	NEDL1	21,26	RNF43	NEDL1	54894	23072	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RNF43 interacts with NEDL1 and regulates p53-mediated transcription .
24466159	0	RNF43	87,92	RING_finger_protein_43	63,85	RNF43	RING finger protein 43	54894	54894	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of two Wnt-responsive elements in the intron of RING_finger_protein_43 -LRB- RNF43 -RRB- gene .
26980022	0	RNF43	24,29	Ring_finger_protein_43	0,22	RNF43	Ring finger protein 43	54894	54894	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ring_finger_protein_43 -LRB- RNF43 -RRB- expression is associated with genetic_alteration status and poor prognosis among patients with intrahepatic_cholangiocarcinoma .
26350900	0	RNF43	14,19	TCF4	91,95	RNF43	TCF4	54894	6934	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated b-catenin by sequestering TCF4 to the nuclear membrane .
20483786	0	RNF5	24,28	virus-induced_signaling_adaptor	37,68	RNF5	virus-induced signaling adaptor	6048	57506	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The E3 ubiquitin ligase RNF5 targets virus-induced_signaling_adaptor for ubiquitination and degradation .
21635870	0	RNF8	32,36	Plk1	0,4	RNF8	Plk1	9025	5347	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Plk1 is negatively regulated by RNF8 .
16215985	0	RNF8	24,28	UBC13	38,43	RNF8	UBC13	9025	7334	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation .
26865403	0	RNG105	37,43	Caprin1	45,52	RNG105	Caprin1	53872(Tax:10090)	53872(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Comprehensive behavioral analysis of RNG105 -LRB- Caprin1 -RRB- heterozygous mice : Reduced social interaction and attenuated response to novelty .
22162762	0	RNH1	60,64	miR-21	15,21	RNH1	miR-21	6050	406991	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	PTEN modulates miR-21 processing via RNA-regulatory protein RNH1 .
20064878	0	RNPC1	0,5	HuR	66,69	RNPC1	HuR	55544	1994	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	RNPC1 modulates the RNA-binding activity of , and cooperates with , HuR to regulate p21 mRNA stability .
23836903	0	RNPC1	0,5	macrophage_inhibitory_cytokine-1	58,90	RNPC1	macrophage inhibitory cytokine-1	55544	9518	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RNPC1 , an RNA-binding protein and a p53 target , regulates macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- expression through mRNA stability .
21764855	0	RNPC1	35,40	p53	44,47	RNPC1	p53	55544	7157	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	Translational repression of p53 by RNPC1 , a p53 target overexpressed in lymphomas .
20457941	0	RNPC1	0,5	p63	72,75	RNPC1	p63	55544	8626	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RNPC1 , an RNA-binding protein and a target of the p53 family , regulates p63 expression through mRNA stability .
22508983	0	RNPC1	31,36	p73	0,3	RNPC1	p73	56190(Tax:10090)	22062(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	p73 expression is regulated by RNPC1 , a target of the p53 family , via mRNA stability .
2675933	0	RNR2	145,149	ribonucleotide_reductase	120,144	RNR2	ribonucleotide reductase	853427(Tax:4932)	853427(Tax:4932)	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Relationships between sensitivity to hydroxyurea and 4-methyl-5-amino-1-formylisoquinoline_thiosemicarbazone -LRB- MAIO -RRB- and ribonucleotide_reductase RNR2 mRNA levels in strains of Saccharomyces_cerevisiae .
10534126	0	RNS2	66,70	eosinophil-derived_neurotoxin	36,65	RNS2	eosinophil-derived neurotoxin	6036	6036	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	C/EBP regulates the promoter of the eosinophil-derived_neurotoxin / RNS2 gene in human eosinophilic cells .
9490699	0	RNS2	117,121	eosinophil-derived_neurotoxin	86,115	RNS2	eosinophil-derived neurotoxin	6036	6036	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of transcription factor PU .1 in the activity of the intronic enhancer of the eosinophil-derived_neurotoxin -LRB- RNS2 -RRB- gene .
23555696	0	RNase_7	40,47	IL-17A_and_IFN-y	0,16	RNase 7	IL-17A and IFN-y	84659	3605;3458	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	IL-17A_and_IFN-y synergistically induce RNase_7 expression via STAT3 in primary keratinocytes .
23555696	0	RNase_7	40,47	STAT3	63,68	RNase 7	STAT3	84659	6774	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	IL-17A_and_IFN-y synergistically induce RNase_7 expression via STAT3 in primary keratinocytes .
23990920	0	RNase_H1	6,14	P32	42,45	RNase H1	P32	246243	708	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Human RNase_H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processing .
9007060	0	RNase_III	83,92	E3L	50,53	RNase III	E3L	29102	3707592(Tax:10245)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Complementation of deletion of the vaccinia_virus E3L gene by the Escherichia_coli RNase_III gene .
25352621	0	RNase_L	0,7	Filamin_A	23,32	RNase L	Filamin A	6041	2316	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	RNase_L Interacts with Filamin_A To Regulate Actin Dynamics and Barrier Function for Viral Entry .
20875083	0	RNase_L	15,22	IQGAP1	65,71	RNase L	IQGAP1	6041	8826	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of RNase_L with a Ras GTPase-activating-like protein IQGAP1 in mediating the apoptosis of a human cancer cell-line .
9660177	0	RNase_L	0,7	RLI	19,22	RNase L	RLI	6041	6059	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	RNase_L inhibitor -LRB- RLI -RRB- antisense constructions block partially the down regulation of the 2-5A / RNase_L pathway in encephalomyocarditis-virus - -LRB- EMCV -RRB- - infected cells .
9660177	0	RNase_L	96,103	RLI	19,22	RNase L	RLI	6041	6059	Gene	Gene	pathway|amod|START_ENTITY 2-5A|dep|pathway regulation|nmod|2-5A block|dobj|regulation antisense|dep|block antisense|nsubj|inhibitor inhibitor|appos|END_ENTITY	RNase_L inhibitor -LRB- RLI -RRB- antisense constructions block partially the down regulation of the 2-5A / RNase_L pathway in encephalomyocarditis-virus - -LRB- EMCV -RRB- - infected cells .
21060114	0	ROBO1	41,46	SRGAP1	48,54	ROBO1	SRGAP1	6091	57522	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The corticofugal neuron-associated genes ROBO1 , SRGAP1 , and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development .
10230407	0	ROC1	0,4	APC11	19,24	ROC1	APC11	9978	51529	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	ROC1 , a homolog of APC11 , represents a family of cullin partners with an associated ubiquitin ligase activity .
22278918	0	ROCK	15,19	SHP-2	0,5	ROCK	SHP-2	6093	5781	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton .
24065547	0	ROCK-2	78,84	moesin	85,91	ROCK-2	moesin	9475	4478	Gene	Gene	cascade|compound|START_ENTITY cascade|compound|END_ENTITY	Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2 / moesin cascade .
18834107	0	ROCK-II	119,126	Rho_kinase	107,117	ROCK-II	Rho kinase	9475	9475	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Discovery of substituted 4 - -LRB- pyrazol-4-yl -RRB- - phenylbenzodioxane-2-carboxamides as potent and highly selective Rho_kinase -LRB- ROCK-II -RRB- inhibitors .
19036714	0	ROCK1	18,23	JIP-3	56,61	ROCK1	JIP-3	19877(Tax:10090)	30957(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage .
22085929	0	ROCK1	51,56	MYBPH	0,5	ROCK1	MYBPH	6093	4608	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	MYBPH , a transcriptional target of TTF-1 , inhibits ROCK1 , and reduces cell motility and metastasis .
24894676	0	ROCK1	16,21	MiR-186	0,7	ROCK1	MiR-186	6093	406962	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells .
24180482	0	ROCK1	90,95	MicroRNA-124-3p	0,15	ROCK1	MicroRNA-124-3p	6093	406909	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-124-3p inhibits cell migration and invasion in bladder_cancer cells by targeting ROCK1 .
26715279	0	ROCK1	96,101	MicroRNA-145	0,12	ROCK1	MicroRNA-145	6093	406937	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-145 inhibits growth and migration of breast_cancer cells through targeting oncoprotein ROCK1 .
22430126	0	ROCK1	0,5	RhoA	55,59	ROCK1	RhoA	6093	387	Gene	Gene	feedback|nsubj|START_ENTITY feedback|dobj|regulation regulation|nmod|END_ENTITY	ROCK1 feedback regulation of the upstream small GTPase RhoA .
23828571	0	ROCK1	59,64	RhoA	0,4	ROCK1	RhoA	6093	387	Gene	Gene	interaction|nmod|START_ENTITY modulates|dobj|interaction modulates|nsubj|END_ENTITY	RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells .
25944062	0	ROCK1	6,11	RhoA	0,4	ROCK1	RhoA	6093	387	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	RhoA / ROCK1 regulates Avian_Reovirus S1133-induced switch from autophagy to apoptosis .
25944062	0	ROCK1	6,11	RhoA	0,4	ROCK1	RhoA	6093	387	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	RhoA / ROCK1 regulates Avian_Reovirus S1133-induced switch from autophagy to apoptosis .
26785300	0	ROCK1	95,100	TGF-b1	88,94	ROCK1	TGF-b1	81762(Tax:10116)	59086(Tax:10116)	Gene	Gene	pathway|nummod|START_ENTITY effect|dep|pathway effect|nmod|END_ENTITY	Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-b1 / ROCK1 pathway in silicosis in rat .
18461597	0	ROCK1	0,5	TGFbeta3	33,41	ROCK1	TGFbeta3	373970(Tax:9031)	396438(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation .
25358403	0	ROCK1	37,42	ZEB1	31,35	ROCK1	ZEB1	6093	6935	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Clinical significance of mTOR , ZEB1 , ROCK1 expression in lung tissues of pulmonary_fibrosis patients .
25358403	0	ROCK1	37,42	mTOR	25,29	ROCK1	mTOR	6093	21977(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Clinical significance of mTOR , ZEB1 , ROCK1 expression in lung tissues of pulmonary_fibrosis patients .
24573110	0	ROCK1	0,5	miR-145	25,32	ROCK1	miR-145	6093	406937	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	ROCK1 , a novel target of miR-145 , promotes glioma_cell_invasion .
26983670	0	ROCK2	38,43	CC-chemokine_receptor_5	11,34	ROCK2	CC-chemokine receptor 5	25537(Tax:10116)	117029(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of CC-chemokine_receptor_5 on ROCK2 and P-MLC2 expression after focal cerebral_ischaemia-reperfusion injury in rats .
24704824	0	ROCK2	14,19	KAP	0,3	ROCK2	KAP	9475	1033	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway .
24610576	0	ROCK2	124,129	S1379	99,104	ROCK2	S1379	9475	1077743(Tax:198215)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Prostaglandin_E -LRB- 2 -RRB- - dependent blockade of actomyosin and stress fibre formation is mediated through S1379 phosphorylation of ROCK2 .
25771860	0	ROCK2	0,5	b-catenin	75,84	ROCK2	b-catenin	9475	1499	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	ROCK2 promotes HCC proliferation by CEBPD inhibition through phospho-GSK3b / b-catenin signaling .
23024754	0	ROD1	0,4	miR-210	50,57	ROD1	miR-210	9991	406992	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	ROD1 is a seedless target gene of hypoxia-induced miR-210 .
19876748	0	ROF2	27,31	FKBP65	33,39	ROF2	FKBP65	834913(Tax:3702)	834913(Tax:3702)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Arabidopsis ROF2 -LRB- FKBP65 -RRB- in thermotolerance .
9545237	0	ROM2	68,72	RHO1	30,34	ROM2	RHO1	851086(Tax:4932)	856294(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Cell wall integrity modulates RHO1 activity via the exchange factor ROM2 .
24400161	0	ROMK	66,70	KCNJ1	40,45	ROMK	KCNJ1	447262(Tax:8355)	447262(Tax:8355)	Gene	Gene	mutations|appos|START_ENTITY mutations|nummod|END_ENTITY	Identification of compound heterozygous KCNJ1 mutations -LRB- encoding ROMK -RRB- in a kindred with Bartter 's _ syndrome and a functional analysis of their pathogenicity .
16428287	0	ROMK	27,31	WNK1	60,64	ROMK	WNK1	3758	65125	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|isoforms isoforms|compound|END_ENTITY	Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms .
16775035	0	ROMK	39,43	WNK1	0,4	ROMK	WNK1	3758	65125	Gene	Gene	independent|compound|START_ENTITY expression|nmod|independent affects|dobj|expression affects|nsubj|END_ENTITY	WNK1 affects surface expression of the ROMK potassium channel independent of WNK4 .
19244242	0	ROMK	14,18	WNK1	65,69	ROMK	WNK1	56379(Tax:10090)	232341(Tax:10090)	Gene	Gene	channel|compound|START_ENTITY Regulation|nmod|channel homeostasis|nsubj|Regulation homeostasis|nmod|kinase kinase|compound|END_ENTITY	Regulation of ROMK channel and K + homeostasis by kidney-specific WNK1 kinase .
21355052	0	ROMK	51,55	WNK1	99,103	ROMK	WNK1	3758	65125	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1 .
16775035	0	ROMK	39,43	WNK4	77,81	ROMK	WNK4	3758	65266	Gene	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	WNK1 affects surface expression of the ROMK potassium channel independent of WNK4 .
24197061	0	ROMK	33,37	intersectin_1	68,81	ROMK	intersectin 1	3758	6453	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	MicroRNA-194 -LRB- miR-194 -RRB- regulates ROMK channel activity by targeting intersectin_1 .
25322850	0	ROMK1	82,87	SPAK	0,4	ROMK1	SPAK	447262(Tax:8355)	53416(Tax:10090)	Gene	Gene	Down-Regulation|nmod|START_ENTITY Down-Regulation|compound|END_ENTITY	SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K Channel ROMK1 .
11082293	0	RON	37,40	receptor_tyrosine_kinase	41,65	RON	receptor tyrosine kinase	4486	5979	Gene	Gene	Overexpression|nmod|START_ENTITY END_ENTITY|nsubj|Overexpression	Overexpression and activation of the RON receptor_tyrosine_kinase in a panel of human colorectal_carcinoma cell lines .
11281194	0	RON	48,51	receptor_tyrosine_kinase	52,76	RON	receptor tyrosine kinase	4486	5979	Gene	Gene	distribution|nmod|START_ENTITY analysis|nmod|distribution END_ENTITY|nsubj|analysis	Immunohistochemical analysis of distribution of RON receptor_tyrosine_kinase in human digestive organs .
20363625	0	RON	43,46	receptor_tyrosine_kinase	47,71	RON	receptor tyrosine kinase	4486	5979	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Identification of a novel series of potent RON receptor_tyrosine_kinase inhibitors .
20358644	0	RON	4,7	vascular_endothelial_growth_factor	43,77	RON	vascular endothelial growth factor	4486	7422	Gene	Gene	receptor|compound|START_ENTITY regulates|nsubj|receptor regulates|dobj|production production|compound|END_ENTITY	The RON tyrosine kinase receptor regulates vascular_endothelial_growth_factor production in pancreatic_cancer cells .
8467707	0	RONU	42,46	Rowett_nude	24,35	RONU	Rowett nude	287469(Tax:10116)	287469(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regional mapping of the Rowett_nude gene -LRB- RONU -RRB- to rat chromosome 10q24 -- > q32 by localizing linked SYB2 and GH loci .
22434040	0	ROP6	17,21	NFR5	37,41	ROP6	NFR5	829654(Tax:3702)	100034751(Tax:34305)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The small GTPase ROP6 interacts with NFR5 and is involved in nodule formation in Lotus_japonicus .
24379361	0	ROR1	0,4	TCL1	23,27	ROR1	TCL1	26563(Tax:10090)	21432(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	ROR1 can interact with TCL1 and enhance leukemogenesis in E - TCL1 transgenic_mice .
23565190	0	RORA	74,78	NPSR1	111,116	RORA	NPSR1	6095	387129	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Interaction between retinoid_acid receptor-related orphan receptor alpha -LRB- RORA -RRB- and neuropeptide_S_receptor_1 -LRB- NPSR1 -RRB- in asthma .
19786043	0	RORA	130,134	RAR-related_orphan_receptor_alpha	95,128	RORA	RAR-related orphan receptor alpha	6095	6095	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Convergence of linkage , gene expression and association data demonstrates the influence of the RAR-related_orphan_receptor_alpha -LRB- RORA -RRB- gene on neovascular AMD : a systems biology based approach .
26184991	0	RORA	40,44	Retinoid-related_orphan_receptor_alpha	0,38	RORA	Retinoid-related orphan receptor alpha	6095	6095	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Retinoid-related_orphan_receptor_alpha -LRB- RORA -RRB- gene variation is associated with trait depression .
22869035	0	RORA	121,125	retinoid-related_orphan_receptor_alpha	81,119	RORA	retinoid-related orphan receptor alpha	6095	6095	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A genome-wide association study of post-traumatic_stress_disorder identifies the retinoid-related_orphan_receptor_alpha -LRB- RORA -RRB- gene as a significant risk locus .
24891616	0	RORa	0,4	E2F1	14,18	RORa	E2F1	6095	1869	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	RORa binds to E2F1 to inhibit cell proliferation and regulate mammary gland branching morphogenesis .
18055760	0	RORalpha	173,181	NR1H3	204,209	RORalpha	NR1H3	19883(Tax:10090)	22259(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Identification of oxysterol_7alpha-hydroxylase -LRB- Cyp7b1 -RRB- as a novel retinoid-related_orphan_receptor_alpha -LRB- RORalpha -RRB- -LRB- NR1F1 -RRB- target gene and a functional cross-talk between RORalpha and liver X receptor -LRB- NR1H3 -RRB- .
9278389	0	RORalpha	89,97	apolipoprotein_A-I	30,48	RORalpha	apolipoprotein A-I	19883(Tax:10090)	11806(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional regulation of apolipoprotein_A-I gene expression by the nuclear receptor RORalpha .
15790933	0	RORalpha	88,96	apolipoprotein_A5	30,47	RORalpha	apolipoprotein A5	6095	116519	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional regulation of apolipoprotein_A5 gene expression by the nuclear receptor RORalpha .
10601979	0	RORalpha	65,73	oxytocin	24,32	RORalpha	oxytocin	19883(Tax:10090)	18429(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|promoter promoter|compound|END_ENTITY	Activation of the mouse oxytocin promoter by the orphan receptor RORalpha .
18172893	0	ROS	89,92	Hsp70	110,115	ROS	Hsp70	44175	44920(Tax:7227)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Adverse effect of tannery waste leachates in transgenic Drosophila_melanogaster : role of ROS in modulation of Hsp70 , oxidative stress and apoptosis .
9879655	0	ROS-GC1	53,60	Rod_outer_segment_membrane_guanylate_cyclase_type_1	0,51	ROS-GC1	Rod outer segment membrane guanylate cyclase type 1	3000	3000	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rod_outer_segment_membrane_guanylate_cyclase_type_1 -LRB- ROS-GC1 -RRB- gene : structure , organization and regulation by phorbol_ester , a protein_kinase_C activator .
15728668	0	ROXY1	0,5	glutaredoxin	29,41	ROXY1	glutaredoxin	820200(Tax:3702)	824655(Tax:3702)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	ROXY1 , a member of the plant glutaredoxin family , is required for petal development in Arabidopsis_thaliana .
12724644	0	RP1	87,90	retinitis_pigmentosa_1	63,85	RP1	retinitis pigmentosa 1	6101	6101	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of RP1L1 , a highly polymorphic paralog of the retinitis_pigmentosa_1 -LRB- RP1 -RRB- gene .
24115036	0	RP105	64,69	CD180	71,76	RP105	CD180	883708(Tax:272947)	17079(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	An unexpected intriguing effect of Toll-like receptor regulator RP105 -LRB- CD180 -RRB- on atherosclerosis formation with alterations on B-cell activation .
12714520	0	RP105	57,62	CD19	0,4	RP105	CD19	883708(Tax:272947)	12478(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes .
15852007	0	RP105	88,93	Toll-like_receptor_4	23,43	RP105	Toll-like receptor 4	883708(Tax:272947)	7099	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of Toll-like_receptor_4 signaling by the Toll-like receptor homolog RP105 .
12634863	0	RP1L1	78,83	retinitis_pigmentosa_1-like1	43,71	RP1L1	retinitis pigmentosa 1-like1	94137	94137	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterisation of the retinitis_pigmentosa_1-like1 gene -LRB- RP1L1 -RRB- : a novel candidate for retinal_degenerations .
9418727	0	RP2	68,71	CSNB4	23,28	RP2	CSNB4	6102	60506	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of CSNBX -LRB- CSNB4 -RRB- between the retinitis_pigmentosa loci RP2 and RP3 on proximal Xp .
21282572	0	RP2	67,70	retinitis_pigmentosa_2	43,65	RP2	retinitis pigmentosa 2	406755(Tax:7955)	406755(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Knockdown of the zebrafish ortholog of the retinitis_pigmentosa_2 -LRB- RP2 -RRB- gene results in retinal_degeneration .
21738648	0	RP2	47,50	retinitis_pigmentosa_2	23,45	RP2	retinitis pigmentosa 2	6102	6102	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Functional analysis of retinitis_pigmentosa_2 -LRB- RP2 -RRB- protein reveals variable pathogenic potential of disease-associated missense variants .
26383048	0	RP2	32,35	retinitis_pigmentosa_2	8,30	RP2	retinitis pigmentosa 2	19889(Tax:10090)	19889(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Loss of retinitis_pigmentosa_2 -LRB- RP2 -RRB- protein affects cone photoreceptor sensory cilium elongation in mice .
16731582	0	RPA	0,3	ARF1	42,46	RPA	ARF1	818088(Tax:3702)	842268(Tax:3702)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	RPA , a class II ARFGAP protein , activates ARF1 and U5 and plays a role in root hair development in Arabidopsis .
10064605	0	RPA	75,78	DNA-dependent_protein_kinase	82,110	RPA	DNA-dependent protein kinase	6117	5591	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nmod|END_ENTITY	Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent_protein_kinase and dissociates RPA : DNA-PK complexes .
25113031	0	RPA	15,18	PALB2	28,33	RPA	PALB2	6117	79728	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery .
17981954	0	RPA	35,38	replication_protein_A	12,33	RPA	replication protein A	6117	6117	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of replication_protein_A -LRB- RPA -RRB- in human spermatogenesis .
26403191	0	RPA1	15,19	PTEN	0,4	RPA1	PTEN	68275(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PTEN regulates RPA1 and protects DNA replication forks .
17035231	0	RPA2	0,4	ATR	39,42	RPA2	ATR	6118	545	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint .
10336450	0	RPA32	57,62	replication_protein_A_middle_subunit	19,55	RPA32	replication protein A middle subunit	6118	6118	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of replication_protein_A_middle_subunit -LRB- RPA32 -RRB- leads to a disassembly of the RPA heterotrimer .
19180575	0	RPAP3	0,5	Reptin	21,27	RPAP3	Reptin	79657	10856	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage .
17532615	0	RPB1	76,80	RNA_polymerase_II	57,74	RPB1	RNA polymerase II	5430	5430	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Higher-level phylogeny of Foraminifera inferred from the RNA_polymerase_II -LRB- RPB1 -RRB- gene .
23223234	0	RPB1	31,35	RPO21	37,42	RPB1	RPO21	851415(Tax:4932)	851415(Tax:4932)	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	The fidelity of transcription : RPB1 -LRB- RPO21 -RRB- mutations that increase transcriptional slippage in S. _ cerevisiae .
25718342	1	RPC1063	36,43	S1P1	57,61	RPC1063	S1P1	3969634(Tax:316056)	1901	Gene	Gene	Properties|nmod|START_ENTITY Properties|appos|END_ENTITY	Pharmacokinetic Properties of RPC1063 , a Selective S1P1 and S1P5 Receptor Agonist , Significantly Contribute to Efficacy in Animal Models of Inflammatory_Bowel_Disease .
10079324	0	RPD3	0,4	REC3	6,10	RPD3	REC3	855386(Tax:4932)	855386(Tax:4932)	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	RPD3 -LRB- REC3 -RRB- mutations affect mitotic recombination in Saccharomyces_cerevisiae .
21229300	0	RPE65	14,19	CRALBP	21,27	RPE65	CRALBP	6121	6017	Gene	Gene	CD68|compound|START_ENTITY CD68|appos|END_ENTITY	Evaluation of RPE65 , CRALBP , VEGF , CD68 , and tyrosinase gene expression in human retinal pigment epithelial cells cultured on amniotic membrane .
21229300	0	RPE65	14,19	VEGF	29,33	RPE65	VEGF	6121	7422	Gene	Gene	CD68|compound|START_ENTITY CD68|appos|END_ENTITY	Evaluation of RPE65 , CRALBP , VEGF , CD68 , and tyrosinase gene expression in human retinal pigment epithelial cells cultured on amniotic membrane .
23041370	0	RPEL	26,30	Phactr1	18,25	RPEL	Phactr1	221692	221692	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity .
11978759	0	RPGR	10,14	ORF15	20,25	RPGR	ORF15	6103	6103	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration .
18332319	0	RPGR	91,95	ORF15	78,83	RPGR	ORF15	6103	6103	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Discordant phenotypes in fraternal twins having an identical mutation in exon ORF15 of the RPGR gene .
20200501	0	RPGR	80,84	retinitis_pigmentosa_GTPase_regulator_interacting_protein_1	4,63	RPGR	retinitis pigmentosa GTPase regulator interacting protein 1	571327(Tax:7955)	568018(Tax:7955)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	The retinitis_pigmentosa_GTPase_regulator_interacting_protein_1 -LRB- RPGRIP1 -RRB- links RPGR to the nephronophthisis protein network .
21689635	0	RPGRIP1L	70,78	NPHP-8	39,45	RPGRIP1L	NPHP-8	23322	23322	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Caenorhabditis_elegans ciliary protein NPHP-8 , the homologue of human RPGRIP1L , is required for ciliogenesis and chemosensation .
15986426	0	RPIP9	14,19	Rap2_interacting_protein_9	21,47	RPIP9	Rap2 interacting protein 9	154661	154661	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of RPIP9 -LRB- Rap2_interacting_protein_9 -RRB- is activated in breast_carcinoma and correlates with a poor prognosis .
26220995	0	RPL11	39,44	MDM2	19,23	RPL11	MDM2	6135	4193	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
26220995	0	RPL11	39,44	MDM2	19,23	RPL11	MDM2	6135	4193	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
21804542	0	RPL11	75,80	PICT1	55,60	RPL11	PICT1	6135	29997	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11 .
9920051	0	RPL14	79,84	ribosomal_protein_L14	51,72	RPL14	ribosomal protein L14	9045	9045	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Trinucleotide repeat length variation in the human ribosomal_protein_L14 gene -LRB- RPL14 -RRB- : localization to 3p21 .3 and loss of heterozygosity in lung and oral_cancers .
26092250	0	RPL18	62,67	NS1	13,16	RPL18	NS1	6141	10625	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	Dengue virus NS1 protein interacts with the ribosomal protein RPL18 : This interaction is required for viral translation and replication in Huh-7 cells .
26687066	0	RPL26	69,74	p53	35,38	RPL26	p53	6154	7157	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p .
15707898	0	RPM-1	73,78	DLK-1	16,21	RPM-1	DLK-1	179259(Tax:6239)	173128(Tax:6239)	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development .
17698012	0	RPM-1	11,16	GLO-4	83,88	RPM-1	GLO-4	179259(Tax:6239)	179306(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	C. _ elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1 .
25881688	0	RPN2	59,63	ribophorin_II	44,57	RPN2	ribophorin II	6185	6185	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The expression and clinical significance of ribophorin_II -LRB- RPN2 -RRB- in human breast_cancer .
2066112	0	RPN_II	30,36	ribophorin_II	15,28	RPN II	ribophorin II	6185	6185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the ribophorin_II -LRB- RPN_II -RRB- gene to human chromosome 20q12-q13 .1 by in-situ hybridization .
23223234	0	RPO21	37,42	RPB1	31,35	RPO21	RPB1	851415(Tax:4932)	851415(Tax:4932)	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	The fidelity of transcription : RPB1 -LRB- RPO21 -RRB- mutations that increase transcriptional slippage in S. _ cerevisiae .
21115310	0	RPO30	84,89	RNA_polymerase_subunit	60,82	RPO30	RNA polymerase subunit	3707593(Tax:10245)	3707593(Tax:10245)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Use of the Capripoxvirus homologue of Vaccinia_virus 30 kDa RNA_polymerase_subunit -LRB- RPO30 -RRB- gene as a novel diagnostic and genotyping target : development of a classical PCR method to differentiate Goat poxvirus from Sheep poxvirus .
17647292	0	RPS17	28,33	Ribosomal_protein_S17	0,21	RPS17	Ribosomal protein S17	6218	6218	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ribosomal_protein_S17 gene -LRB- RPS17 -RRB- is mutated in Diamond-Blackfan_anemia .
19953637	0	RPS17	69,74	ribosomal_protein_S17	41,62	RPS17	ribosomal protein S17	6218	6218	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	A novel initiation codon mutation in the ribosomal_protein_S17 gene -LRB- RPS17 -RRB- in a patient with Diamond-Blackfan_anemia .
2507396	0	RPS17	28,33	ribosomal_protein_S17	48,69	RPS17	ribosomal protein S17	39088(Tax:7227)	39088(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	The Drosophila_melanogaster RPS17 gene encoding ribosomal_protein_S17 .
12358933	0	RPS19	178,183	ribosomal_protein_S19	155,176	RPS19	ribosomal protein S19	6223	6223	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Familial_transient_erythroblastopenia of childhood is associated with the chromosome 19q13 .2 region but not caused by mutations in coding sequences of the ribosomal_protein_S19 -LRB- RPS19 -RRB- gene .
19101821	0	RPS25	81,86	ribosomal_protein_S25	53,74	RPS25	ribosomal protein S25	100465707	100465707	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	cDNA , genomic sequence cloning and overexpression of ribosomal_protein_S25 gene -LRB- RPS25 -RRB- from the Giant_Panda .
26336993	0	RPS3	0,4	MICU1	75,80	RPS3	MICU1	6188	10367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto_C / Ca2 + / MICU1 dependent mitochondrial signaling .
23747103	0	RPS8	103,107	ribosomal_protein_S8	81,101	RPS8	ribosomal protein S8	101117800	101117800	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Discrimination between ovine Babesia and Theileria species in China based on the ribosomal_protein_S8 -LRB- RPS8 -RRB- gene .
18202837	0	RPSA	71,75	laminin_receptor	48,64	RPSA	laminin receptor	100125628(Tax:9940)	100125628(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structural and functional analysis of the ovine laminin_receptor gene -LRB- RPSA -RRB- : Possible involvement of the LRP/LR protein in scrapie response .
24648519	0	RRAD	43,47	Ras-related_associated_with_diabetes	49,85	RRAD	Ras-related associated with diabetes	6236	6236	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ras-induced epigenetic inactivation of the RRAD -LRB- Ras-related_associated_with_diabetes -RRB- gene promotes glucose uptake in a human ovarian_cancer model .
26767763	0	RRAGC	0,5	mTORC1	25,31	RRAGC	mTORC1	64121	382056(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	RRAGC Mutations Activate mTORC1 Signaling in Follicular_Lymphoma .
22709790	0	RRBP1	46,51	ribosome_binding_protein_1	18,44	RRBP1	ribosome binding protein 1	6238	6238	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of ribosome_binding_protein_1 -LRB- RRBP1 -RRB- in breast_cancer .
19890057	0	RREB-1	0,6	HLA-G	41,46	RREB-1	HLA-G	6239	3135	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	RREB-1 is a transcriptional repressor of HLA-G .
19558368	0	RREB-1	31,37	p53	45,48	RREB-1	p53	6239	7157	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter .
24348900	0	RREB1	96,101	DJ-1	120,124	RREB1	DJ-1	68750(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	RREB1	96,101	DJ-1	58,62	RREB1	DJ-1	68750(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
24348900	0	RREB1	96,101	DJ-1	86,90	RREB1	DJ-1	68750(Tax:10090)	57320(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice .
10899132	0	RRF	35,38	ribosome_recycling_factor	8,33	RRF	ribosome recycling factor	92399	92399	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of ribosome_recycling_factor -LRB- RRF -RRB- in translational coupling .
26252353	0	RRM1	0,4	CYP19A1	20,27	RRM1	CYP19A1	6240	1588	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	RRM1	0,4	CYP19A1	20,27	RRM1	CYP19A1	6240	1588	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26842788	0	RRM1	131,135	ERCC1	118,123	RRM1	ERCC1	6240	2067	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
26252353	0	RRM1	0,4	TOP2A	13,18	RRM1	TOP2A	6240	7153	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	RRM1	0,4	TOP2A	13,18	RRM1	TOP2A	6240	7153	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
25573098	0	RRM1	27,31	TUBB3	33,38	RRM1	TUBB3	6240	10381	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Expression of ERCC1 , TYMS , RRM1 , TUBB3 , non-muscle myosin II , myoglobin and MyoD1 in lung_adenocarcinoma pleural_effusions predicts survival in patients receiving platinum-based chemotherapy .
26252353	0	RRM1	0,4	TUBB3	6,11	RRM1	TUBB3	6240	10381	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	RRM1	0,4	TUBB3	6,11	RRM1	TUBB3	6240	10381	Gene	Gene	CYP2D6|compound|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26842788	0	RRM1	131,135	TUBB3	137,142	RRM1	TUBB3	6240	10381	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
25573098	0	RRM1	27,31	TYMS	21,25	RRM1	TYMS	6240	7298	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Expression of ERCC1 , TYMS , RRM1 , TUBB3 , non-muscle myosin II , myoglobin and MyoD1 in lung_adenocarcinoma pleural_effusions predicts survival in patients receiving platinum-based chemotherapy .
26842788	0	RRM1	131,135	TYMS	125,129	RRM1	TYMS	6240	7298	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
23719266	0	RRM2	0,4	Bcl-2	15,20	RRM2	Bcl-2	6241	596	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	RRM2 regulates Bcl-2 in head_and_neck_and_lung_cancers : a potential target for cancer therapy .
17222798	0	RRM2	0,4	MMP-9	33,38	RRM2	MMP-9	6241	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	RRM2 induces NF-kappaB-dependent MMP-9 activation and enhances cellular invasiveness .
19250552	0	RRM2	138,142	VEGF	63,67	RRM2	VEGF	6241	7422	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo : implication of RRM2 in angiogenesis .
19250552	0	RRM2	18,22	VEGF	63,67	RRM2	VEGF	6241	7422	Gene	Gene	Overexpression|nmod|START_ENTITY decreases|nsubj|Overexpression decreases|dobj|production production|compound|END_ENTITY	Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo : implication of RRM2 in angiogenesis .
24947616	0	RRM2B	66,71	FOXO3	17,22	RRM2B	FOXO3	50484	2309	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Tumor suppressor FOXO3 regulates ribonucleotide reductase subunit RRM2B and impacts on survival of cancer patients .
26733354	0	RRM2B	46,51	PYCR1	0,5	RRM2B	PYCR1	50484	5831	Gene	Gene	Interact|nmod|START_ENTITY Interact|nsubj|END_ENTITY	PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress .
10341208	0	RRP1	87,91	Nop52	22,27	RRP1	Nop52	851660(Tax:4932)	8568	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The nucleolar antigen Nop52 , the human homologue of the yeast ribosomal RNA processing RRP1 , is recruited at late stages of nucleologenesis .
24260471	0	RRP1B	34,39	BRD4	0,4	RRP1B	BRD4	72462(Tax:10090)	57261(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	BRD4 short isoform interacts with RRP1B , SIPA1 and components of the LINC complex at the inner face of the nuclear membrane .
20677810	0	RS1	15,18	Retinoschisin	0,13	RS1	Retinoschisin	20147(Tax:10090)	20147(Tax:10090)	Gene	Gene	+|appos|START_ENTITY +|amod|END_ENTITY	Retinoschisin -LRB- RS1 -RRB- interacts with negatively charged lipid bilayers in the presence of Ca2 + : an atomic force microscopy study .
26800264	0	RS2	124,127	Raffinose_Synthase_2	102,122	RS2	Raffinose Synthase 2	100158227(Tax:3847)	100158227(Tax:3847)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Environmental Stability of Seed Carbohydrate Profiles in Soybeans Containing Different Alleles of the Raffinose_Synthase_2 -LRB- RS2 -RRB- Gene .
11684016	0	RSK	29,32	C/EBPbeta	0,9	RSK	C/EBPbeta	20111(Tax:10090)	12608(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival .
23401857	0	RSK	24,27	Gab2	0,4	RSK	Gab2	6196	9846	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility .
24205356	0	RSK	0,3	eIF4B	37,42	RSK	eIF4B	6196	1975	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	RSK activation of translation factor eIF4B drives abnormal increases of laminin y2 and MYC protein during neoplastic progression to squamous_cell_carcinoma .
24627490	0	RSK	206,209	extracellular_signal-regulated_kinase	134,171	RSK	extracellular signal-regulated kinase	6196	5594	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Complex formation between S100B protein and the p90 ribosomal S6 kinase -LRB- RSK -RRB- in malignant_melanoma is calcium-dependent and inhibits extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated phosphorylation of RSK .
21659537	0	RSK	198,201	mTORC1	221,227	RSK	mTORC1	6197	382056(Tax:10090)	Gene	Gene	p90|appos|START_ENTITY p90|nmod|control control|nmod|protein protein|amod|END_ENTITY	Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular _ signal-regulated_kinase kinase -LRB- MEK -RRB- , extracellular_signal-regulated_kinase -LRB- ERK -RRB- , and p90 -LRB- RSK -RRB- in the control of mTORC1 protein signaling by phorbol_esters .
22797077	0	RSK	0,3	mTORC1	43,49	RSK	mTORC1	6196	382056(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth .
25889895	0	RSK	16,19	mTORC1	59,65	RSK	mTORC1	6196	382056(Tax:10090)	Gene	Gene	inhibitors|compound|START_ENTITY alter|nsubj|inhibitors alter|dobj|END_ENTITY	Two widely used RSK inhibitors , BI-D1870 and SL0101 , alter mTORC1 signaling in a RSK-independent manner .
23970478	0	RSK	8,11	p90	4,7	RSK	p90	6196	57650	Gene	Gene	members|compound|START_ENTITY members|amod|END_ENTITY	The p90 RSK family members : common functions and isoform specificity .
11964089	0	RSK	35,38	ribosomal_S6_kinase	14,33	RSK	ribosomal S6 kinase	6196	6196	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of ribosomal_S6_kinase -LRB- RSK -RRB- during porcine oocyte maturation .
9792677	0	RSK-B	0,5	ribosomal_S6_kinase	15,34	RSK-B	ribosomal S6 kinase	8986	6196	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	RSK-B , a novel ribosomal_S6_kinase family member , is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase -LRB- p38alphaMAPK -RRB- .
26862730	0	RSK1	14,18	EBP50	34,39	RSK1	EBP50	6195	9368	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Ras-activated RSK1 phosphorylates EBP50 to regulate its nuclear localization and promote cell proliferation .
26527685	0	RSK1	43,47	Ribosomal_S6_Kinase_1	20,41	RSK1	Ribosomal S6 Kinase 1	6195	6195	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Structural basis of Ribosomal_S6_Kinase_1 -LRB- RSK1 -RRB- inhibition by S100B Protein : modulation of the Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- signaling cascade in a calcium-dependent way .
10469565	0	RSK1	23,27	Ribosomal_S6_kinase_1	0,21	RSK1	Ribosomal S6 kinase 1	6195	6195	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Ribosomal_S6_kinase_1 -LRB- RSK1 -RRB- activation requires signals dependent on and independent of the MAP kinase ERK .
21075852	0	RSK1	45,49	ribosomal_S6_kinase_1	22,43	RSK1	ribosomal S6 kinase 1	6195	6195	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of ribosomal_S6_kinase_1 -LRB- RSK1 -RRB- in IFN signaling .
15109498	0	RSK2	23,27	ATF4	0,4	RSK2	ATF4	6197	468	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology ; implication for Coffin-Lowry_Syndrome .
21041626	0	RSK2	37,41	Cdc25C	45,51	RSK2	Cdc25C	399376(Tax:8355)	398119(Tax:8355)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation .
17785202	0	RSK2	16,20	FGFR3	0,5	RSK2	FGFR3	6197	2261	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway .
23911878	0	RSK2	86,90	IMP1	0,4	RSK2	IMP1	6197	10642	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1 .
25178409	0	RSPO1	68,73	R-spondin_1	55,66	RSPO1	R-spondin 1	284654	284654	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	The association of radiographic progression with serum R-spondin_1 -LRB- RSPO1 -RRB- levels or Dickkopf-1 -LRB- DKK1 -RRB- / RSPO1 ratios in rheumatoid_arthritis patients : clinical evidence for reciprocal inhibition between DKK1 and RSPO1 .
11558907	0	RSTN	49,53	resistin	39,47	RSTN	resistin	57264(Tax:10090)	57264(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms of the resistin -LRB- RSTN -RRB- gene .
25500545	0	RSUME	0,5	VHL	15,18	RSUME	VHL	25950	7428	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	RSUME inhibits VHL and regulates its tumor suppressor function .
11711586	0	RTA	76,79	ORF50	81,86	RTA	ORF50	4961526(Tax:37296)	4961526(Tax:37296)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of a cellular protein that interacts and synergizes with the RTA -LRB- ORF50 -RRB- protein of Kaposi 's _ sarcoma-associated_herpesvirus in transcriptional activation .
18786687	0	RTA	40,43	ORF59	78,83	RTA	ORF59	116535	4961492(Tax:37296)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element .
15194757	0	RTA	137,140	RBP-J	0,5	RTA	RBP-J	4961526(Tax:37296)	3516	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	RBP-J -LRB- CSL -RRB- is essential for activation of the K14/vGPCR promoter of Kaposi 's _ sarcoma-associated_herpesvirus by the lytic switch protein RTA .
21169295	0	RTEF-1	36,42	VEGF-B	93,99	RTEF-1	VEGF-B	21679(Tax:10090)	22340(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	The endothelium-dependent effect of RTEF-1 in pressure overload cardiac_hypertrophy : role of VEGF-B .
17338827	0	RTEL	101,105	regulator_of_telomere_length_elongation_helicase	46,94	RTEL	regulator of telomere length elongation helicase	505721(Tax:9913)	51750	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification and characterization of bovine regulator_of_telomere_length_elongation_helicase gene -LRB- RTEL -RRB- : molecular cloning , expression distribution , splice variants and DNA methylation profile .
24523019	0	RTEL1	45,50	helicase_1	33,43	RTEL1	helicase 1	51750	56916	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Regulator of telomere elongation helicase_1 -LRB- RTEL1 -RRB- rs6010620 polymorphism contribute to increased risk of glioma .
11442633	0	RTK	77,80	DAlk	39,43	RTK	DAlk	38559(Tax:7227)	53425(Tax:7227)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of DAlk : a novel Drosophila_melanogaster RTK which drives ERK activation in vivo .
17285636	0	RTK	58,61	Jelly_Belly	11,22	RTK	Jelly Belly	38559(Tax:7227)	36295(Tax:7227)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The ligand Jelly_Belly -LRB- Jeb -RRB- activates the Drosophila Alk RTK to drive PC12 cell differentiation , but is unable to activate the mouse ALK RTK .
25319891	0	RTK	72,75	Receptor_Tyrosine_Kinase	46,70	RTK	Receptor Tyrosine Kinase	5979	5979	Gene	Gene	Activation|appos|START_ENTITY Activation|compound|END_ENTITY	Quantification of the Effects of Mutations on Receptor_Tyrosine_Kinase -LRB- RTK -RRB- Activation in Mammalian Cells .
16934227	0	RTK	26,29	Receptor_tyrosine_kinase	0,24	RTK	Receptor tyrosine kinase	5979	5979	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Receptor_tyrosine_kinase -LRB- RTK -RRB- inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian_cancer cell lines when used in combination with cytotoxic agents .
20026268	0	RTK	50,53	Y1111	31,36	RTK	Y1111	5979	1149255(Tax:187410)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A negative regulatory role for Y1111 on the Tie-2 RTK .
15662113	0	RTK	79,82	e-cadherin	38,48	RTK	e-cadherin	5979	999	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	No one-way street : cross-talk between e-cadherin and receptor_tyrosine_kinase -LRB- RTK -RRB- signaling : a mechanism to regulate RTK activity .
19360360	0	RTKN	51,55	miR-145	0,7	RTKN	miR-145	6242	406937	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	miR-145 inhibits breast_cancer cell growth through RTKN .
16965550	0	RTN3	11,15	BACE1	43,48	RTN3	BACE1	10313	23621	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein .
15532024	0	RTN4R	35,40	Nogo-66_receptor	17,33	RTN4R	Nogo-66 receptor	65078	65078	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations of the Nogo-66_receptor -LRB- RTN4R -RRB- gene in schizophrenia .
26305187	0	RTVP-1	0,6	N-WASP	73,79	RTVP-1	N-WASP	11010	8976	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK .
26305187	0	RTVP-1	0,6	N-WASP	73,79	RTVP-1	N-WASP	11010	8976	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK .
15104277	0	RUNX1	42,47	AML1	36,40	RUNX1	AML1	861	861	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosome 21 tandem repetition and AML1 -LRB- RUNX1 -RRB- gene amplification .
23709277	0	RUNX1	25,30	AML1	19,23	RUNX1	AML1	861	861	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The Runt domain of AML1 -LRB- RUNX1 -RRB- binds a sequence-conserved RNA motif that mimics a DNA element .
20875871	0	RUNX1	15,20	CLCA2	0,5	RUNX1	CLCA2	861	9635	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	CLCA2 , a novel RUNX1 partner gene in a therapy-related_leukemia with t -LRB- 1 ; 21 -RRB- -LRB- p22 ; q22 -RRB- .
17575132	0	RUNX1	14,19	EVI1	32,36	RUNX1	EVI1	861	861	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Repression of RUNX1 activity by EVI1 : a new role of EVI1 in leukemogenesis .
22689058	0	RUNX1	101,106	EVI1	64,68	RUNX1	EVI1	861	2122	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Functional characterization of the promoter region of the human EVI1 gene in acute_myeloid_leukemia : RUNX1 and ELK1 directly regulate its transcription .
20439113	0	RUNX1	68,73	GM-CSF	49,55	RUNX1	GM-CSF	861	1437	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	Transcriptional and epigenetic regulation of the GM-CSF promoter by RUNX1 .
18695000	0	RUNX1	49,54	HIPK2	67,72	RUNX1	HIPK2	861	28996	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2 : implications for leukemogenesis .
25150295	0	RUNX1	33,38	Hmga2	0,5	RUNX1	Hmga2	12394(Tax:10090)	15364(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice .
12771199	0	RUNX1	63,68	MIP-1alpha	40,50	RUNX1	MIP-1alpha	861	6348	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ .
23848403	0	RUNX1	0,5	PF4	81,84	RUNX1	PF4	861	5196	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	RUNX1 , but not its familial platelet_disorder mutants , synergistically activates PF4 gene expression in combination with ETS family proteins .
21252065	0	RUNX1	107,112	PRKCQ	70,75	RUNX1	PRKCQ	861	5588	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Platelet protein kinase C-theta deficiency with human RUNX1 mutation : PRKCQ is a transcriptional target of RUNX1 .
21252065	0	RUNX1	54,59	PRKCQ	70,75	RUNX1	PRKCQ	861	5588	Gene	Gene	mutation|compound|START_ENTITY kinase|nmod|mutation kinase|parataxis|target target|nsubj|END_ENTITY	Platelet protein kinase C-theta deficiency with human RUNX1 mutation : PRKCQ is a transcriptional target of RUNX1 .
15654961	0	RUNX1	44,49	PSORS2	66,72	RUNX1	PSORS2	861	79092	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Lack of evidence for genetic association to RUNX1 binding site at PSORS2 in different German psoriasis cohorts .
24327541	0	RUNX1	63,68	RUNX1T1	88,95	RUNX1	RUNX1T1	861	862	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of topoisomerase_II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1 .
21723253	0	RUNX1	21,26	SERPINB13	0,9	RUNX1	SERPINB13	861	5275	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	SERPINB13 is a novel RUNX1 target gene .
14608356	0	RUNX1	21,26	SLC22A4	43,50	RUNX1	SLC22A4	12394(Tax:10090)	30805(Tax:10090)	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	An intronic SNP in a RUNX1 binding site of SLC22A4 , encoding an organic cation transporter , is associated with rheumatoid_arthritis .
14608357	0	RUNX1	11,16	SLC9A3R1	46,54	RUNX1	SLC9A3R1	861	9368	Gene	Gene	variant|compound|START_ENTITY variant|nmod|END_ENTITY	A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis .
22040971	0	RUNX1	1,6	WNT5A	43,48	RUNX1	WNT5A	12394(Tax:10090)	22418(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	-LSB- RUNX1 regulates transcription activity of WNT5A in mouse bone marrow derived mesenchymal stem cells -RSB- .
26716895	0	RUNX1	70,75	miR-215	0,7	RUNX1	miR-215	861	406997	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-215 promotes malignant progression of gastric_cancer by targeting RUNX1 .
15051730	0	RUNX1	76,81	tissue_inhibitor_of_metalloproteinase_1	14,53	RUNX1	tissue inhibitor of metalloproteinase 1	861	7076	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of tissue_inhibitor_of_metalloproteinase_1 gene transcription by RUNX1 and RUNX2 .
24327541	0	RUNX1T1	88,95	RUNX1	63,68	RUNX1T1	RUNX1	862	861	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of topoisomerase_II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1 .
26935542	0	RUNX2	68,73	BMP-2	62,67	RUNX2	BMP-2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Linarin promotes osteogenic differentiation by activating the BMP-2 / RUNX2 pathway via protein kinase A signaling .
15304489	0	RUNX2	50,55	Insulin-like_growth_factor-1	0,28	RUNX2	Insulin-like growth factor-1	860	3479	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Insulin-like_growth_factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol_3-kinase / ERK-dependent and Akt-independent signaling pathway .
21542013	0	RUNX2	87,92	LRP5	96,100	RUNX2	LRP5	860	4041	Gene	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Functional relevance of the BMD-associated polymorphism rs312009 : novel involvement of RUNX2 in LRP5 transcriptional regulation .
27033977	0	RUNX2	31,36	MED23	9,14	RUNX2	MED23	12393(Tax:10090)	70208(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development .
15564063	0	RUNX2	35,40	MMP-13	14,20	RUNX2	MMP-13	860	4322	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage .
24069422	0	RUNX2	20,25	TGF-b	36,41	RUNX2	TGF-b	860	7040	Gene	Gene	target|compound|START_ENTITY target|nmod|END_ENTITY	Cadherin_6 is a new RUNX2 target in TGF-b signalling pathway .
16407259	0	RUNX2	44,49	cdc2	74,78	RUNX2	cdc2	860	983	Gene	Gene	factor|compound|START_ENTITY factor|nmod|END_ENTITY	Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation .
25356868	0	RUNX2	13,18	microRNA-320	0,12	RUNX2	microRNA-320	860	407037	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	microRNA-320 / RUNX2 axis regulates adipocytic differentiation of human mesenchymal -LRB- skeletal -RRB- stem cells .
20665536	0	RUNX2	69,74	odontogenic_ameloblast-associated_protein	4,45	RUNX2	odontogenic ameloblast-associated protein	860	54959	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The odontogenic_ameloblast-associated_protein -LRB- ODAM -RRB- cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20 .
27102439	0	RUNX2	25,30	receptor_tyrosine_kinase	41,65	RUNX2	receptor tyrosine kinase	860	5979	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The transcription factor RUNX2 regulates receptor_tyrosine_kinase expression in melanoma .
22713854	0	RUNX2	50,55	runt_related_transcription_factor_2	13,48	RUNX2	runt related transcription factor 2	367218(Tax:10116)	367218(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role for runt_related_transcription_factor_2 -LRB- RUNX2 -RRB- as a transcriptional repressor in luteinizing granulosa cells .
16164020	0	RUNX3	0,5	CD11a	36,41	RUNX3	CD11a	864	3683	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters .
18430739	0	RUNX3	52,57	Enhancer_of_zeste_homologue_2	0,29	RUNX3	Enhancer of zeste homologue 2	864	2146	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	Enhancer_of_zeste_homologue_2 -LRB- EZH2 -RRB- down-regulates RUNX3 by increasing histone H3 methylation .
16373335	0	RUNX3	0,5	FoxO3a	22,28	RUNX3	FoxO3a	12399(Tax:10090)	56484(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	RUNX3 cooperates with FoxO3a to induce apoptosis in gastric_cancer cells .
23851507	0	RUNX3	0,5	MYCN	21,25	RUNX3	MYCN	864	4613	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RUNX3 interacts with MYCN and facilitates protein degradation in neuroblastoma .
23912048	0	RUNX3	45,50	MicroRNA-106b	0,13	RUNX3	MicroRNA-106b	864	406900	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-106b regulates the tumor suppressor RUNX3 in laryngeal_carcinoma cells .
20176475	0	RUNX3	46,51	MicroRNA-130b	0,13	RUNX3	MicroRNA-130b	864	406920	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-130b regulates the tumour suppressor RUNX3 in gastric_cancer .
27048832	0	RUNX3	60,65	MicroRNA-130b	0,13	RUNX3	MicroRNA-130b	864	406920	Gene	Gene	regulating|dobj|START_ENTITY suppressor|advcl|regulating suppressor|nsubj|functions functions|amod|END_ENTITY	MicroRNA-130b functions as a tumor suppressor by regulating RUNX3 in epithelial_ovarian_cancer .
26898755	0	RUNX3	33,38	Pak1	42,46	RUNX3	Pak1	12399(Tax:10090)	18479(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Threonine 209 phosphorylation on RUNX3 by Pak1 is a molecular switch for its dualistic functions .
18767071	0	RUNX3	43,48	Pim-1	0,5	RUNX3	Pim-1	12399(Tax:10090)	18712(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|kinase kinase|amod|END_ENTITY	Pim-1 kinase phosphorylates and stabilizes RUNX3 and alters its subcellular localization .
22580604	0	RUNX3	53,58	Pin1	17,21	RUNX3	Pin1	864	5300	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast_cancer .
22479382	0	RUNX3	0,5	intercellular_adhesion_molecule_3	16,49	RUNX3	intercellular adhesion molecule 3	864	3385	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RUNX3 regulates intercellular_adhesion_molecule_3 -LRB- ICAM-3 -RRB- expression during macrophage differentiation and monocyte extravasation .
23338485	0	RUNX3	77,82	miR-301a	14,22	RUNX3	miR-301a	12399(Tax:10090)	723834(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric_cancer .
24447545	0	RUNX3	0,5	miR-30a	40,47	RUNX3	miR-30a	864	407029	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric_cancer cells .
20353948	0	RUNX3	0,5	p53	72,75	RUNX3	p53	864	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53 .
22253448	0	RUNX3	45,50	runt-related_transcription_factor_3	8,43	RUNX3	runt-related transcription factor 3	864	864	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of runt-related_transcription_factor_3 -LRB- RUNX3 -RRB- in transcription regulation of natural_cytotoxicity_receptor_1 -LRB- NCR1/NKp46 -RRB- , an activating natural_killer _ -LRB- NK -RRB- _ cell_receptor .
17085650	0	RUNX3	0,5	vascular_endothelial_growth_factor	33,67	RUNX3	vascular endothelial growth factor	864	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	RUNX3 inhibits the expression of vascular_endothelial_growth_factor and reduces the angiogenesis , growth , and metastasis of human gastric_cancer .
24447545	0	RUNX3	0,5	vimentin	16,24	RUNX3	vimentin	864	7431	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric_cancer cells .
19159630	0	RUNX_3	67,73	P53/P21	38,45	RUNX 3	P53/P21	864	7157;644914	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of activation of P53/P21 and demethylation of RUNX_3 in the cytotoxicity against Lovo cells induced by 5-Aza-2 ' - deoxycytidine .
17587236	0	RVE2	33,37	CIR1	27,31	RVE2	CIR1	833700(Tax:3702)	833700(Tax:3702)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive expression of CIR1 -LRB- RVE2 -RRB- affects several circadian-regulated processes and seed germination in Arabidopsis .
20664520	0	RXFP1	52,57	AC2	67,70	RXFP1	AC2	59350	108	Gene	Gene	complex|compound|START_ENTITY complex|dep|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
20664520	0	RXFP1	52,57	AKAP79	59,65	RXFP1	AKAP79	59350	9495	Gene	Gene	complex|compound|START_ENTITY complex|dep|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
22257012	0	RXFP1	145,150	RXFP3	133,138	RXFP1	RXFP3	59350	51289	Gene	Gene	Minimization|nmod|START_ENTITY Minimization|nmod|relaxin-family_peptide_3_receptor relaxin-family_peptide_3_receptor|appos|END_ENTITY	Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family_peptide_3_receptor -LRB- RXFP3 -RRB- over RXFP1 .
20664520	0	RXFP1	52,57	beta-arrestin_2	72,87	RXFP1	beta-arrestin 2	59350	409	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
16725278	0	RXFP1	89,94	leucine-rich_repeat-containing_G-protein-coupled_receptor-7	28,87	RXFP1	leucine-rich repeat-containing G-protein-coupled receptor-7	295144(Tax:10116)	295144(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Comparative localization of leucine-rich_repeat-containing_G-protein-coupled_receptor-7 -LRB- RXFP1 -RRB- mRNA and -LSB- 33P -RSB- - relaxin binding sites in rat brain : restricted somatic co-expression a clue to relaxin action ?
24640564	0	RXFP2	51,56	RLF	31,34	RXFP2	RLF	122042	6018	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of RLF / INSL3 receptor RXFP2 in boar testes .
26220663	0	RXFP2	47,52	insulin-like_peptide_3	23,45	RXFP2	insulin-like peptide 3	450220(Tax:9615)	403436(Tax:9615)	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Expression analyses of insulin-like_peptide_3 , RXFP2 , LH receptor , and 3b-hydroxysteroid dehydrogenase in testes of normal and cryptorchid dogs .
26220663	0	RXFP2	47,52	insulin-like_peptide_3	23,45	RXFP2	insulin-like peptide 3	450220(Tax:9615)	403436(Tax:9615)	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Expression analyses of insulin-like_peptide_3 , RXFP2 , LH receptor , and 3b-hydroxysteroid dehydrogenase in testes of normal and cryptorchid dogs .
22257012	0	RXFP3	133,138	RXFP1	145,150	RXFP3	RXFP1	51289	59350	Gene	Gene	relaxin-family_peptide_3_receptor|appos|START_ENTITY Minimization|nmod|relaxin-family_peptide_3_receptor Minimization|nmod|END_ENTITY	Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family_peptide_3_receptor -LRB- RXFP3 -RRB- over RXFP1 .
24065955	0	RXFP3	10,15	Relaxin-3	0,9	RXFP3	Relaxin-3	51289	117579	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Relaxin-3 / RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control .
24297931	0	RXFP3	10,15	Relaxin-3	0,9	RXFP3	Relaxin-3	51289	117579	Gene	Gene	system|compound|START_ENTITY regulates|nsubj|system END_ENTITY|parataxis|regulates	Relaxin-3 / RXFP3 system regulates alcohol-seeking .
24711793	0	RXFP3	10,15	Relaxin-3	0,9	RXFP3	Relaxin-3	51289	117579	Gene	Gene	networks|nummod|START_ENTITY END_ENTITY|dep|networks	Relaxin-3 / RXFP3 networks : an emerging target for the treatment of depression and other neuropsychiatric_diseases ?
25257104	0	RXFP3	121,126	Relaxin-3	0,9	RXFP3	Relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY role|nmod|signalling Implications|nmod|role receptor|dep|Implications receptor|amod|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
25849482	0	RXFP3	20,25	Relaxin-3	0,9	RXFP3	Relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	Signalling|appos|START_ENTITY Signalling|compound|END_ENTITY	Relaxin-3 Receptor -LRB- RXFP3 -RRB- Signalling Mediates Stress-Related Alcohol Preference in Mice .
26023064	0	RXFP3	92,97	Relaxin-3	82,91	RXFP3	Relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	Deficiency|compound|START_ENTITY Deficiency|nmod|Administration Administration|nmod|END_ENTITY	Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3 / RXFP3 Deficiency .
26023064	0	RXFP3	92,97	Relaxin-3	82,91	RXFP3	Relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	Deficiency|compound|START_ENTITY Deficiency|nmod|Administration Administration|nmod|END_ENTITY	Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3 / RXFP3 Deficiency .
22257012	0	RXFP3	133,138	relaxin-3	22,31	RXFP3	relaxin-3	51289	117579	Gene	Gene	relaxin-family_peptide_3_receptor|appos|START_ENTITY Minimization|nmod|relaxin-family_peptide_3_receptor Minimization|nmod|END_ENTITY	Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family_peptide_3_receptor -LRB- RXFP3 -RRB- over RXFP1 .
22854307	0	RXFP3	85,90	relaxin-3	94,103	RXFP3	relaxin-3	294807(Tax:10116)	266997(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY weight_gain|nmod|activation weight_gain|nmod|peptides peptides|amod|END_ENTITY	Increased feeding and body weight_gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides : functional and therapeutic implications .
23380674	0	RXFP3	28,33	relaxin-3	8,17	RXFP3	relaxin-3	294807(Tax:10116)	266997(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Central relaxin-3 receptor -LRB- RXFP3 -RRB- activation decreases_anxiety - _ and_depressive-like_behaviours in the rat .
23440673	0	RXFP3	76,81	relaxin-3	15,24	RXFP3	relaxin-3	51289	117579	Gene	Gene	Elucidation|nmod|START_ENTITY Elucidation|nmod|interactions interactions|amod|END_ENTITY	Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3 .
24615237	0	RXFP3	92,97	relaxin-3	173,182	RXFP3	relaxin-3	51289	117579	Gene	Gene	interact|compound|START_ENTITY Glu141|nmod|interact charged|dobj|Glu141 charged|nmod|positively positively|acl|charged charged|dobj|residues residues|nmod|END_ENTITY	The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3 .
24681162	0	RXFP3	41,46	relaxin-3	21,30	RXFP3	relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	injection|appos|START_ENTITY injection|nmod|receptor receptor|amod|END_ENTITY	Central injection of relaxin-3 receptor -LRB- RXFP3 -RRB- antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice .
25257104	0	RXFP3	121,126	relaxin-3	111,120	RXFP3	relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
26057358	0	RXFP3	28,33	relaxin-3	8,17	RXFP3	relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Central relaxin-3 receptor -LRB- RXFP3 -RRB- activation reduces elevated , but not basal , anxiety-like behaviour in C57BL/6J mice .
26607097	0	RXFP3	18,23	relaxin-3	8,17	RXFP3	relaxin-3	294807(Tax:10116)	266997(Tax:10116)	Gene	Gene	system|nummod|START_ENTITY Role|dep|system Role|nmod|END_ENTITY	Role of relaxin-3 / RXFP3 system in stress-induced binge-like eating in female rats .
10212874	0	RXR	46,49	RAR	40,43	RXR	RAR	6256	10966	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The independent and combined effects of RAR - , RXR - , and VDR-selective ligands on the growth of squamous_cell_carcinoma in vitro .
11877083	0	RXR	33,36	RAR	22,25	RXR	RAR	6256	5914	Gene	Gene	retinoids|compound|START_ENTITY or/and|dobj|retinoids or/and|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of selective RAR or/and RXR retinoids on the proliferation and differentiation of NB4 cells and their mechanisms -RSB- .
7779113	0	RXR	54,57	RAR	48,51	RXR	RAR	6256	5914	Gene	Gene	repressor|amod|START_ENTITY repressor|nmod|END_ENTITY	The orphan receptor TAK1 acts as a repressor of RAR - , RXR - and T3R-mediated signaling pathways .
7852380	0	RXR	61,64	RAR	35,38	RXR	RAR	6256	5914	Gene	Gene	retinoid_X_receptor|appos|START_ENTITY receptor|dep|retinoid_X_receptor receptor|appos|END_ENTITY	Endogenous retinoic_acid receptor -LRB- RAR -RRB- - retinoid_X_receptor -LRB- RXR -RRB- heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes .
9491782	0	RXR	10,13	RAR	0,3	RXR	RAR	6256	5914	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	RAR - , not RXR , ligands inhibit cell activation and prevent apoptosis in B-lymphocytes .
9952315	0	RXR	109,112	RAR	45,48	RXR	RAR	6256	5914	Gene	Gene	agonists|appos|START_ENTITY agonists|nmod|agonists agonists|nsubj|synergism synergism|appos|END_ENTITY	Greater synergism of retinoic_acid_receptor -LRB- RAR -RRB- agonists with vitamin_D3 than that of retinoid_X_receptor -LRB- RXR -RRB- agonists with regard to growth inhibition and differentiation induction in monoblastic_leukemia cells .
11683493	0	RXR	77,80	RARalpha	63,71	RXR	RARalpha	6256	5914	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Retinoic_acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells .
17613435	0	RXR	15,18	RARalpha	37,45	RXR	RARalpha	6256	5914	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation .
19791803	0	RXR	80,83	retinoid_X_receptor	59,78	RXR	retinoid X receptor	6256	6256	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Modeling , synthesis and biological evaluation of potential retinoid_X_receptor -LRB- RXR -RRB- selective agonists : novel analogues of 4 - -LSB- 1 - -LRB- 3,5,5,8,8-pentamethyl-5 ,6,7,8 - tetrahydro-2-naphthyl -RRB- ethynyl -RSB- benzoic_acid -LRB- bexarotene -RRB- .
24180745	0	RXR	81,84	retinoid_X_receptor	60,79	RXR	retinoid X receptor	6256	6256	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Modeling , synthesis , and biological evaluation of potential retinoid_X_receptor -LRB- RXR -RRB- selective agonists : novel analogues of 4 - -LSB- 1 - -LRB- 3,5,5,8,8-pentamethyl-5 ,6,7,8 - tetrahydro-2-naphthyl -RRB- ethynyl -RSB- benzoic_acid -LRB- bexarotene -RRB- and -LRB- E -RRB- -3 - -LRB- 3 - -LRB- 1,2,3,4-tetrahydro-1 ,1,4,4,6 - pentamethylnaphthalen-7-yl -RRB- -4 - hydroxyphenyl -RRB- acrylic_acid -LRB- CD3254 -RRB- .
26159320	0	RXR	70,73	retinoid_X_receptor	49,68	RXR	retinoid X receptor	6256	6256	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and expression analysis of the retinoid_X_receptor -LRB- RXR -RRB- gene in golden pompano Trachinotus ovatus fed Artemia nauplii with different enrichments .
21709632	0	RXR-alpha	108,117	Retinoid_X_Receptor-alpha	81,106	RXR-alpha	Retinoid X Receptor-alpha	6256	6256	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Correlation of Peroxisome_Proliferator-Activated_Receptor-gamma -LRB- PPAR-gamma -RRB- and Retinoid_X_Receptor-alpha -LRB- RXR-alpha -RRB- expression with clinical risk factors in patients with advanced carotid_atherosclerosis .
25592151	0	RXRA	104,108	HULC	19,23	RXRA	HULC	6256	728655	Gene	Gene	Pathway|compound|START_ENTITY Modulates|nmod|Pathway Modulates|nsubj|END_ENTITY	Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9-Mediated RXRA Signaling Pathway .
18713813	0	RXRB	26,30	Retinoid_X_receptor_beta	0,24	RXRB	Retinoid X receptor beta	20182(Tax:10090)	20182(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Retinoid_X_receptor_beta -LRB- RXRB -RRB- expression in Sertoli cells controls cholesterol homeostasis and spermiation .
24051096	0	RXRa	66,70	COX2	9,13	RXRa	COX2	20181(Tax:10090)	17709(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY END_ENTITY|nmod|downregulation	Elevated COX2 expression and PGE2 production by downregulation of RXRa in senescent macrophages .
24371580	0	RXRa	71,75	IFN-y	106,111	RXRa	IFN-y	6256	3458	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|production production|amod|END_ENTITY	Relevance of nuclear receptor expression in a Tchreg cell line , HOZOT : RXRa and PPARy negatively regulate IFN-y production .
22808166	0	RXRa	21,25	STAT1	0,5	RXRa	STAT1	6256	6772	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	STAT1 interacts with RXRa to upregulate ApoCII gene expression in macrophages .
23977068	0	RXRa	69,73	retinoid_X_receptor_alpha	42,67	RXRa	retinoid X receptor alpha	20181(Tax:10090)	20181(Tax:10090)	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Sexually dimorphic genome-wide binding of retinoid_X_receptor_alpha -LRB- RXRa -RRB- determines male-female differences in the expression of hepatic lipid processing genes in mice .
12969790	0	RXRalpha	27,35	Retinoid-X-receptor_alpha	0,25	RXRalpha	Retinoid-X-receptor alpha	6256	6256	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Retinoid-X-receptor_alpha -LRB- RXRalpha -RRB- expression during laryngeal carcinogenesis : detrimental or beneficial event ?
17475324	0	RXRalpha	0,8	pregnancy-specific_glycoprotein_5	23,56	RXRalpha	pregnancy-specific glycoprotein 5	6256	5673	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	RXRalpha regulates the pregnancy-specific_glycoprotein_5 gene transcription through a functional retinoic_acid responsive element .
9924183	0	RXRalpha	52,60	retinoid-X_receptor_alpha	25,50	RXRalpha	retinoid-X receptor alpha	25271(Tax:10116)	25271(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Glucocorticoids increase retinoid-X_receptor_alpha -LRB- RXRalpha -RRB- expression and enhance thyroid hormone action in primary cultured rat hepatocytes .
27060496	0	RYBP	13,17	FANK1	33,38	RYBP	FANK1	23429	92565	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Proapoptotic RYBP interacts with FANK1 and induces tumor cell apoptosis through the AP-1 signaling pathway .
26711264	0	RYBP	17,21	Polycomb	8,16	RYBP	Polycomb	56353(Tax:10090)	12416(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of Polycomb RYBP in Maintaining the B-1 to B-2 B-Cell Lineage Switch in Adult Hematopoiesis .
19098711	0	RYBP	0,4	p53	16,19	RYBP	p53	23429	7157	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	RYBP stabilizes p53 by modulating MDM2 .
11956217	0	RYK	0,3	EphB2	72,77	RYK	EphB2	6259	2048	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	RYK , a catalytically inactive receptor tyrosine kinase , associates with EphB2 and EphB3 but does not interact with AF-6 .
1354642	0	RYR1	101,105	ryanodine_receptor	81,99	RYR1	ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms and deduced amino_acid substitutions in the coding sequence of the ryanodine_receptor -LRB- RYR1 -RRB- gene in individuals with malignant_hyperthermia .
21157159	0	RYR1	60,64	ryanodine_receptor	35,53	RYR1	ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Molecular genetic analysis of the ryanodine_receptor gene -LRB- RYR1 -RRB- in Korean malignant_hyperthermia families -RSB- .
8994903	0	RYR1	147,151	ryanodine_receptor	127,145	RYR1	ryanodine receptor	396718(Tax:9823)	396718(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Technical note : use of a PCR-single strand conformation polymorphism -LRB- PCR-SSCP -RRB- for detection of a point mutation in the swine ryanodine_receptor -LRB- RYR1 -RRB- gene .
24176615	0	RYR1	37,41	ryanodine_receptor_1	15,35	RYR1	ryanodine receptor 1	396718(Tax:9823)	396718(Tax:9823)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	The effects of ryanodine_receptor_1 -LRB- RYR1 -RRB- mutation on plasma cytokines and catecholamines during prolonged restraint in pigs .
19931341	0	RYR1	75,79	ryanodine_receptor_type_1	48,73	RYR1	ryanodine receptor type 1	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Postmortem molecular screening for mutations in ryanodine_receptor_type_1 -LRB- RYR1 -RRB- gene in psychiatric patients suspected of having died of neuroleptic_malignant_syndrome .
17376685	0	RYR1	101,105	skeletal_muscle_ryanodine_receptor	65,99	RYR1	skeletal muscle ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Centronuclear_myopathy due to a de novo dominant mutation in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
19303294	0	RYR1	126,130	skeletal_muscle_ryanodine_receptor	90,124	RYR1	skeletal muscle ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Late-onset axial_myopathy with cores due to a novel heterozygous dominant mutation in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
20080402	0	RYR1	130,134	skeletal_muscle_ryanodine_receptor	94,128	RYR1	skeletal muscle ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Multi-minicore disease and atypical periodic_paralysis associated with novel mutations in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
20461000	0	RYR1	22,26	skeletal_muscle_ryanodine_receptor	44,78	RYR1	skeletal muscle ryanodine receptor	6261	6261	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	Functional studies of RYR1 mutations in the skeletal_muscle_ryanodine_receptor using human RYR1 complementary DNA .
21514828	0	RYR1	95,99	skeletal_muscle_ryanodine_receptor	59,93	RYR1	skeletal muscle ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	King-Denborough_syndrome with and without mutations in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
23329375	0	RYR1	103,107	skeletal_muscle_ryanodine_receptor	67,101	RYR1	skeletal muscle ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel late-onset axial_myopathy associated with mutations in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
8661021	0	RYR1	77,81	skeletal_muscle_ryanodine_receptor	41,75	RYR1	skeletal muscle ryanodine receptor	6261	6261	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The structural organization of the human skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
22222782	0	RYR2	56,60	ryanodine_receptor_2	34,54	RYR2	ryanodine receptor 2	6262	6262	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Postmortem genetic testing of the ryanodine_receptor_2 -LRB- RYR2 -RRB- gene in a cohort of sudden unexplained death cases .
10902927	0	RYR3	74,78	ryanodine_receptor_3	47,67	RYR3	ryanodine receptor 3	6263	6263	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure of the 5 ' end of the porcine ryanodine_receptor_3 gene -LRB- RYR3 -RRB- .
9515741	0	RYR3	68,72	ryanodine_receptor_type_3	41,66	RYR3	ryanodine receptor type 3	6263	6263	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	cDNA cloning and sequencing of the human ryanodine_receptor_type_3 -LRB- RYR3 -RRB- reveals a novel alternative splice site in the RYR3 gene .
9735344	0	Ra	57,59	Lama5	14,19	Ra	Lama5	20672(Tax:10090)	16776(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Evaluation of Lama5 as a candidate for the mouse ragged -LRB- Ra -RRB- mutation .
9271224	0	Ra	183,185	ragged	175,181	Ra	ragged	20672(Tax:10090)	20672(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Tissue-specific expression of the human laminin_alpha5-chain , and mapping of the gene to human chromosome 20q13.2-13 .3 and to distal mouse chromosome 2 near the locus for the ragged -LRB- Ra -RRB- mutation .
9735344	0	Ra	57,59	ragged	49,55	Ra	ragged	20672(Tax:10090)	20672(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Evaluation of Lama5 as a candidate for the mouse ragged -LRB- Ra -RRB- mutation .
26823012	0	Rab1	0,4	WHAMM	14,19	Rab1	WHAMM	5861	123720	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Rab1 recruits WHAMM during membrane remodeling but limits actin nucleation .
19570034	0	Rab10	32,37	GDI-1	0,5	Rab10	GDI-1	10890	2664	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation .
18076383	0	Rab10	0,5	GLUT4	28,33	Rab10	GLUT4	10890	6517	Gene	Gene	START_ENTITY|nmod|translocation translocation|compound|END_ENTITY	Rab10 in insulin-stimulated GLUT4 translocation .
19570034	0	Rab10	32,37	GLUT4	60,65	Rab10	GLUT4	10890	6517	Gene	Gene	START_ENTITY|nmod|translocation translocation|compound|END_ENTITY	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation .
20643919	0	Rab10	20,25	TLR4	38,42	Rab10	TLR4	10890	7099	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|END_ENTITY	Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane .
17079274	0	Rab11	42,47	Bchs	0,4	Rab11	Bchs	42501(Tax:7227)	33819(Tax:7227)	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Bchs , a BEACH domain protein , antagonizes Rab11 in synapse morphogenesis and other developmental events .
15689490	0	Rab11	0,5	E-cadherin	80,90	Rab11	E-cadherin	403957(Tax:9615)	442858(Tax:9615)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transport transport|nmod|END_ENTITY	Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin .
18579802	0	Rab11	7,12	E-cadherin	64,74	Rab11	E-cadherin	403957(Tax:9615)	442858(Tax:9615)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|trafficking trafficking|amod|END_ENTITY	Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis .
25117932	0	Rab11	0,5	E-cadherin	16,26	Rab11	E-cadherin	8766	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Rab11 regulates E-cadherin expression and induces cell transformation in colorectal_carcinoma .
21790911	0	Rab11	18,23	Rab11-FIP3	54,64	Rab11	Rab11-FIP3	8766	9727;8766;8517	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|regulation regulation|nmod|END_ENTITY	Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3 / arfophilin-1 localization in mitotic cells .
15292201	0	Rab11	29,34	Sec15	0,5	Rab11	Sec15	8766	54536	Gene	Gene	GTPase|amod|START_ENTITY effector|nmod|GTPase effector|nsubj|END_ENTITY	Sec15 is an effector for the Rab11 GTPase in mammalian cells .
16155582	0	Rab11	21,26	Sec15	0,5	Rab11	Sec15	42501(Tax:7227)	42499(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo .
18845944	0	Rab11	59,64	huntingtin	14,24	Rab11	huntingtin	53869(Tax:10090)	15194(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	A function of huntingtin in guanine_nucleotide exchange on Rab11 .
16148947	0	Rab11-FIP3	0,10	Arf6	34,38	Rab11-FIP3	Arf6	9727;8766;8517	382	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis .
21790911	0	Rab11-FIP3	54,64	Rab11	18,23	Rab11-FIP3	Rab11	9727;8766;8517	8766	Gene	Gene	regulation|nmod|START_ENTITY roles|nmod|regulation roles|nmod|END_ENTITY	Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3 / arfophilin-1 localization in mitotic cells .
12393859	0	Rab11_family_interacting_protein_2	0,34	Myosin_Vb	51,60	Rab11 family interacting protein 2	Myosin Vb	477834(Tax:9615)	480220(Tax:9615)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Rab11_family_interacting_protein_2 associates with Myosin_Vb and regulates plasma membrane recycling .
26299802	0	Rab11a	84,90	Flotillin-2	9,20	Rab11a	Flotillin-2	8766	2319	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Reggie-1 / Flotillin-2 regulates integrin trafficking and focal adhesion turnover via Rab11a .
25232007	0	Rab11a	53,59	TBC1D9B	0,7	Rab11a	TBC1D9B	403957(Tax:9615)	481460(Tax:9615)	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells .
25925668	0	Rab12	89,94	DENND3	39,45	Rab12	DENND3	201475	22898	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy .
23478338	0	Rab12	0,5	mTORC1	16,22	Rab12	mTORC1	201475	382056(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4 .
25713415	0	Rab13	18,23	DENND2B	0,7	Rab13	DENND2B	5872	6764	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior .
25074980	0	Rab13	0,5	Mst1	36,40	Rab13	Mst1	68328(Tax:10090)	15235(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking .
18332131	0	Rab14	29,34	Annexin_A2	0,10	Rab14	Annexin A2	94197(Tax:10116)	56611(Tax:10116)	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Annexin_A2 interactions with Rab14 in alveolar type II cells .
12105226	0	Rab15	64,69	Mammalian_suppressor_of_Sec4	0,28	Rab15	Mammalian suppressor of Sec4	376267	5877	Gene	Gene	effect|nmod|START_ENTITY modulates|dobj|effect modulates|nsubj|END_ENTITY	Mammalian_suppressor_of_Sec4 modulates the inhibitory effect of Rab15 during early endocytosis .
16147880	0	Rab18	64,69	RAB18	76,81	Rab18	RAB18	22931	22931	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a novel splice variant of human Rab18 gene -LRB- RAB18 -RRB- .
21551065	0	Rab1A	52,57	Roco2	30,35	Rab1A	Roco2	5861	120892	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton .
25446900	0	Rab1A	0,5	mTORC1	12,18	Rab1A	mTORC1	5861	382056(Tax:10090)	Gene	Gene	Activator|nsubj|START_ENTITY Activator|amod|END_ENTITY	Rab1A Is an mTORC1 Activator and a Colorectal Oncogene .
23188820	0	Rab1B	103,108	myotubularin-related_protein_6	35,65	Rab1B	myotubularin-related protein 6	100126191(Tax:10116)	305935(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Phosphatidylinositol 3-phosphatase myotubularin-related_protein_6 -LRB- MTMR6 -RRB- is regulated by small GTPase Rab1B in the early secretory and autophagic pathways .
17429068	0	Rab1b	0,5	GBF1	21,25	Rab1b	GBF1	81876	8729	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association .
16473605	0	Rab2	57,61	GRASP55	44,51	Rab2	GRASP55	5862	26003	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Purification and functional interactions of GRASP55 with Rab2 .
15485821	0	Rab2	56,60	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	Rab2	Glyceraldehyde-3-phosphate dehydrogenase	5862	2597	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity .
19106097	0	Rab2	0,4	glyceraldehyde-3-phosphate_dehydrogenase	14,54	Rab2	glyceraldehyde-3-phosphate dehydrogenase	5862	2597	Gene	Gene	utilizes|nummod|START_ENTITY utilizes|amod|END_ENTITY	Rab2 utilizes glyceraldehyde-3-phosphate_dehydrogenase and protein kinase C -LCB- iota -RCB- to associate with microtubules and to recruit dynein .
16525121	0	Rab21	10,15	Varp	0,4	Rab21	Varp	23011	84079	Gene	Gene	factor|amod|START_ENTITY factor|nsubj|END_ENTITY	Varp is a Rab21 guanine_nucleotide exchange factor and regulates endosome dynamics .
11870209	0	Rab22	17,22	EEA1	38,42	Rab22	EEA1	57403	8411	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking .
20375059	0	Rab23	58,63	smoothened	74,84	Rab23	smoothened	19335(Tax:10090)	319757(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Differential role of Rab proteins in ciliary trafficking : Rab23 regulates smoothened levels .
14722103	0	Rab27A	90,96	Rabphilin	0,9	Rab27A	Rabphilin	50645(Tax:10116)	32002(Tax:7227)	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells .
11980908	1	Rab27a	55,61	Melanophilin	36,48	Rab27a	Melanophilin	5873	79083	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Melanophilin links Rab27a and myosin_Va function in melanosome transport .
12062444	0	Rab27a	28,34	Melanophilin	0,12	Rab27a	Melanophilin	5873	79083	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Melanophilin directly links Rab27a and myosin_Va through its distinct coiled-coil regions .
21740491	0	Rab27a	31,37	Myosin_Va	0,9	Rab27a	Myosin Va	5873	4644	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	Myosin_Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand_factor release from endothelial cells .
22349512	0	Rab27b	0,6	c-kit	17,22	Rab27b	c-kit	5874	3815	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Rab27b regulates c-kit expression by controlling the secretion of stem_cell_factor .
18448665	0	Rab33B	28,34	Atg16L	50,56	Rab33B	Atg16L	83452	55054	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation .
26975471	0	Rab33B	68,74	Atg5	24,28	Rab33B	Atg5	19338(Tax:10090)	11793(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Deciphering the role of Atg5 in nucleotide dependent interaction of Rab33B with the dimeric complex , Atg5-Atg16L1 .
12475955	0	Rab34	82,87	Rab-interacting_lysosomal_protein	105,138	Rab34	Rab-interacting lysosomal protein	83871	83547	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting_lysosomal_protein .
22344257	0	Rab35	0,5	Arf6	16,20	Rab35	Arf6	288700(Tax:10116)	79121(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Rab35 regulates Arf6 activity through centaurin-b2 -LRB- ACAP2 -RRB- during neurite outgrowth .
26725203	0	Rab35	0,5	OCRL	85,89	Rab35	OCRL	11021	4952	Gene	Gene	Recruitment|compound|START_ENTITY Recruitment|nmod|END_ENTITY	Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes .
23353182	0	Rab35	0,5	Rac1	41,45	Rab35	Rac1	11021	5879	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast_cancer cells .
19729655	0	Rab35	0,5	actin	15,20	Rab35	actin	33014(Tax:7227)	40444(Tax:7227)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Rab35 controls actin bundling by recruiting fascin as an effector protein .
18477474	0	Rab38	20,25	Varp	0,4	Rab38	Varp	23682	84079	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Varp interacts with Rab38 and functions as its potential effector .
19833722	0	Rab39a	0,6	caspase-1	13,22	Rab39a	caspase-1	54734	834	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion .
7926025	0	Rab3A	67,72	Rabphilin-3A	50,62	Rab3A	Rabphilin-3A	5864	22895	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	GDP/GTP exchange reaction-stimulating activity of Rabphilin-3A for Rab3A small GTP-binding protein .
19170188	0	Rab3A	52,57	SNAP-29	18,25	Rab3A	SNAP-29	5864	9342	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The SNARE protein SNAP-29 interacts with the GTPase Rab3A : Implications for membrane trafficking in myelinating glia .
8292018	0	Rab3A	60,65	rabphilin-3A	16,28	Rab3A	rabphilin-3A	25531(Tax:10116)	171039(Tax:10116)	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Localization of rabphilin-3A , a putative target protein for Rab3A , at the sites of Ca -LRB- 2 + -RRB- - dependent exocytosis in PC12 cells .
21262767	0	Rab3D	40,45	Tctex-1	0,7	Rab3D	Tctex-1	9545	6993	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Tctex-1 , a novel interaction partner of Rab3D , is required for osteoclastic bone resorption .
25612670	0	Rab3GAP1	15,23	VAP-B	0,5	Rab3GAP1	VAP-B	22930	9217	Gene	Gene	Binds|nmod|START_ENTITY Binds|compound|END_ENTITY	VAP-B Binds to Rab3GAP1 at the ER : Its Implication in Nuclear Envelope Formation through the ER-Golgi Intermediate Compartment .
11278839	0	Rab3a	0,5	Rim1	49,53	Rab3a	Rim1	5864	22999	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique .
19797056	0	Rab4	23,27	D-AKAP2	0,7	Rab4	D-AKAP2	5867	11216	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling .
11336646	0	Rab4	38,42	GLUT4	56,61	Rab4	GLUT4	5867	6517	Gene	Gene	Expression|nmod|START_ENTITY inhibits|nsubj|Expression inhibits|dobj|translocation translocation|compound|END_ENTITY	Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein_kinase_B .
12832475	0	Rab4	106,110	GLUT4	16,21	Rab4	GLUT4	19341(Tax:10090)	20528(Tax:10090)	Gene	Gene	coupling|nmod|START_ENTITY involves|dobj|coupling involves|nsubj|translocation translocation|compound|END_ENTITY	Insulin-induced GLUT4 translocation involves protein_kinase_C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin .
7575609	0	Rab4	0,4	GLUT4	60,65	Rab4	GLUT4	25532(Tax:10116)	25139(Tax:10116)	Gene	Gene	colocalized|nsubjpass|START_ENTITY colocalized|nmod|END_ENTITY	Rab4 , but not the transferrin_receptor , is colocalized with GLUT4 in an insulin-sensitive intracellular compartment in rat skeletal muscle .
9348225	0	Rab4	49,53	GLUT4	85,90	Rab4	GLUT4	19341(Tax:10090)	20528(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|translocation translocation|compound|END_ENTITY	The small guanosine_triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells .
8943343	0	Rab4	18,22	Glut4	72,77	Rab4	Glut4	5867	6517	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of Rab4 in the regulation of subcellular localization of Glut4 in adipocytes .
20209493	0	Rab4	0,4	P-glycoprotein	30,44	Rab4	P-glycoprotein	5867	5243	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rab4 interacts with the human P-glycoprotein and modulates its surface expression in multidrug resistant K562 cells .
16473617	0	Rab4	33,37	Rabaptin-5alpha	39,54	Rab4	Rabaptin-5alpha	5867	9135	Gene	Gene	complex|compound|START_ENTITY complex|dep|END_ENTITY	Expression and properties of the Rab4 , Rabaptin-5alpha , AP-1 complex in endosomal recycling .
26430212	0	Rab4	39,43	Rabaptin5	0,9	Rab4	Rabaptin5	5867	9135	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation .
19302266	0	Rab4	24,28	VEGFR1	0,6	Rab4	VEGFR1	5867	2321	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	VEGFR1 -LRB- Flt1 -RRB- regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching .
11063739	0	Rab4	22,26	syntaxin_4	32,42	Rab4	syntaxin 4	25532(Tax:10116)	81803(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Rab4 with syntaxin_4 .
12837691	0	Rab5	70,74	ALS2	0,4	Rab5	ALS2	5868	57679	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	ALS2 , a novel guanine_nucleotide exchange factor for the small GTPase Rab5 , is implicated in endosomal dynamics .
15388334	0	Rab5	91,95	ALS2CL	0,6	Rab5	ALS2CL	5868	259173	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	ALS2CL , the novel protein highly homologous to the carboxy-terminal half of ALS2 , binds to Rab5 and modulates endosome dynamics .
19013132	0	Rab5	21,25	Caveolin-1	0,10	Rab5	Caveolin-1	5868	857	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction .
11252727	0	Rab5	63,67	EGF_receptor	47,59	Rab5	EGF receptor	5868	1956	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of intracellular trafficking of the EGF_receptor by Rab5 in the absence of phosphatidylinositol_3-kinase activity .
11703925	0	Rab5	45,49	RIN1	90,94	Rab5	RIN1	5868	9610	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Ras-activated endocytosis is mediated by the Rab5 guanine_nucleotide exchange activity of RIN1 .
25800850	0	Rab5	22,26	p110b	43,48	Rab5	p110b	5868	5291	Gene	Gene	Site|compound|START_ENTITY Site|nmod|END_ENTITY	Identification of the Rab5 Binding Site in p110b : Assays for PI3Kb Binding to Rab5 .
9852039	0	Rab5a	37,42	Interferon-gamma	0,16	Rab5a	Interferon-gamma	5868	3458	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells .
10491193	0	Rab5b	32,37	EEA1	22,26	Rab5b	EEA1	5869	8411	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of EEA1 with Rab5b .
10202141	0	Rab6	61,65	GAPCenA	20,27	Rab6	GAPCenA	5870	23637	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Characterization of GAPCenA , a GTPase activating protein for Rab6 , part of which associates with the centrosome .
17475246	0	Rab6	45,49	Giantin	0,7	Rab6	Giantin	5870	2804	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Giantin interacts with both the small GTPase Rab6 and Rab1 .
25754817	0	Rab6	59,63	miR-5100	0,8	Rab6	miR-5100	5870	100847014	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	miR-5100 promotes tumor growth in lung_cancer by targeting Rab6 .
26869029	0	Rab7	84,88	PTEN	0,4	Rab7	PTEN	338382	5728	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7 .
15186776	0	Rab7	17,21	REP-1	22,27	Rab7	REP-1	338382	1121	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Structure of the Rab7 : REP-1 complex : insights into the mechanism of Rab prenylation and choroideremia disease .
15933719	0	Rab7	57,61	RILP	36,40	Rab7	RILP	338382	83547	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recruitment of RILP by small GTPase Rab7 .
22115783	0	Rab7	43,47	phafin1	23,30	Rab7	phafin1	338382	79156	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation .
17395780	0	Rab7b	37,42	TLR4	64,68	Rab7b	TLR4	338382	7099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4 .
19304576	0	Rab8	0,4	ABCA1	15,20	Rab8	ABCA1	4218	19	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages .
11137014	0	Rab8	50,54	FIP-2	0,5	Rab8	FIP-2	4218	10133	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	FIP-2 , a coiled-coil protein , links Huntingtin to Rab8 and modulates cellular morphogenesis .
16541104	0	Rab8	62,66	MSS4	83,87	Rab8	MSS4	4218	5877	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Nucleotide exchange via local protein unfolding -- structure of Rab8 in complex with MSS4 .
22854040	0	Rab8	45,49	Optineurin	0,10	Rab8	Optineurin	4218	10133	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17 .
17507647	0	Rab8a	25,30	Myosin_Vb	0,9	Rab8a	Myosin Vb	4218	4645	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Myosin_Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3 .
20346379	0	Rab9	15,19	TRPC6	66,71	Rab9	TRPC6	9367	7225	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6 .
16533754	0	RabGEF1	0,7	stem_cell_factor	18,34	RabGEF1	stem cell factor	56715(Tax:10090)	17311(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	RabGEF1 regulates stem_cell_factor / c-Kit-mediated signaling events and biological responses in mast cells .
9067750	0	Rab_escort_protein-1	64,84	REP-1	86,91	Rab escort protein-1	REP-1	1121	1121	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular basis of choroideremia -LRB- CHM -RRB- : mutations involving the Rab_escort_protein-1 -LRB- REP-1 -RRB- gene .
11136552	0	Rab_geranylgeranyl_transferase_alpha-subunit	92,136	RABGGTA	138,145	Rab geranylgeranyl transferase alpha-subunit	RABGGTA	5875	5875	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	5 ' - UTR structural organization , transcript expression , and mutational analysis of the human Rab_geranylgeranyl_transferase_alpha-subunit -LRB- RABGGTA -RRB- gene .
21209314	0	Rab_interactor_1	70,86	protein_kinase_D	8,24	Rab interactor 1	protein kinase D	9610	5587	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	A novel protein_kinase_D phosphorylation site in the tumor suppressor Rab_interactor_1 is critical for coordination of cell migration .
24102721	0	Rabankyrin-5	29,41	RhoD	0,4	Rabankyrin-5	RhoD	51479	29984	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor .
24957337	0	Rabaptin-5	50,60	GEF	32,35	Rabaptin-5	GEF	9135	9181	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|mechanism mechanism|nmod|END_ENTITY	Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5 .
11872161	0	Rabaptin-5	38,48	Gamma-adaptin	0,13	Rabaptin-5	Gamma-adaptin	9135	164	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain .
22975325	0	Rabaptin-5	93,103	PKD	0,3	Rabaptin-5	PKD	9135	5587	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	PKD controls avb3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5 .
16473617	0	Rabaptin-5alpha	39,54	Rab4	33,37	Rabaptin-5alpha	Rab4	9135	5867	Gene	Gene	complex|dep|START_ENTITY complex|compound|END_ENTITY	Expression and properties of the Rab4 , Rabaptin-5alpha , AP-1 complex in endosomal recycling .
26430212	0	Rabaptin5	0,9	Rab4	39,43	Rabaptin5	Rab4	9135	5867	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Rabaptin5 is recruited to endosomes by Rab4 and Rabex5 to regulate endosome maturation .
11062261	0	Rabenosyn-5	0,11	hVPS45	54,60	Rabenosyn-5	hVPS45	64145	11311	Gene	Gene	complexed|nsubjpass|START_ENTITY complexed|nmod|END_ENTITY	Rabenosyn-5 , a novel Rab5 effector , is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain .
16407276	0	Rabex-5	44,51	ubiquitin	58,67	Rabex-5	ubiquitin	27342	850620(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The Rab5 guanine_nucleotide exchange factor Rabex-5 binds ubiquitin -LRB- Ub -RRB- and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain .
22649696	0	Rabin8	0,6	Rheb	37,41	Rabin8	Rheb	117177	6009	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6 .
14722103	0	Rabphilin	0,9	Rab27A	90,96	Rabphilin	Rab27A	32002(Tax:7227)	50645(Tax:10116)	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells .
7926025	0	Rabphilin-3A	50,62	Rab3A	67,72	Rabphilin-3A	Rab3A	22895	5864	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	GDP/GTP exchange reaction-stimulating activity of Rabphilin-3A for Rab3A small GTP-binding protein .
23900529	0	Rac	0,3	HSP27	31,36	Rac	HSP27	207	3315	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets .
12915132	0	Rac	19,22	Nischarin	0,9	Rac	Nischarin	207	11188	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK .
12947334	0	Rac	49,52	THP-1	96,101	Rac	THP-1	207	2736	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Mevastatin suppresses lipopolysaccharide-induced Rac activation in the human monocyte cell line THP-1 .
11950933	0	Rac	28,31	Vav	0,3	Rac	Vav	207	7409	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Vav regulates activation of Rac but not Cdc42 during FcgammaR-mediated phagocytosis .
11453646	0	Rac	0,3	tumor_necrosis_factor_alpha	20,47	Rac	tumor necrosis factor alpha	11651(Tax:10090)	21926(Tax:10090)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Rac is activated by tumor_necrosis_factor_alpha and is involved in activation of Erk .
11726672	0	Rac-1	166,171	CDC42	145,150	Rac-1	CDC42	5879	998	Gene	Gene	proteins|nmod|START_ENTITY proteins|appos|subunits subunits|appos|END_ENTITY	Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins , beta gamma subunits , small GTPase CDC42 , and partly by Rac-1 .
17107954	0	Rac-1	80,85	Cdc42	86,91	Rac-1	Cdc42	5879	998	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Phosphorylation of the LFA-1 integrin beta2-chain on Thr-758 leads to adhesion , Rac-1 / Cdc42 activation , and stimulation of CD69 expression in human T cells .
22796473	0	Rac-1	61,66	Cdc42	67,72	Rac-1	Cdc42	5879	998	Gene	Gene	GTPases|appos|START_ENTITY acting|nmod|GTPases acting|dep|END_ENTITY	Desmoglein_3 acting as an upstream regulator of Rho GTPases , Rac-1 / Cdc42 in the regulation of actin organisation and dynamics .
12877655	0	Rac-GAP	24,31	Rac-GTPase-activating_protein	33,62	Rac-GAP	Rac-GTPase-activating protein	9743	9743	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Characterization of the Rac-GAP -LRB- Rac-GTPase-activating_protein -RRB- activity of beta2-chimaerin , a ` non-protein_kinase_C ' phorbol_ester receptor .
12877655	0	Rac-GTPase-activating_protein	33,62	Rac-GAP	24,31	Rac-GTPase-activating protein	Rac-GAP	9743	9743	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Characterization of the Rac-GAP -LRB- Rac-GTPase-activating_protein -RRB- activity of beta2-chimaerin , a ` non-protein_kinase_C ' phorbol_ester receptor .
10779358	0	Rac1	87,91	ADP-ribosylation_factor_6	0,25	Rac1	ADP-ribosylation factor 6	5879	382	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	ADP-ribosylation_factor_6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA .
23707487	0	Rac1	14,18	ARF1	0,4	Rac1	ARF1	5879	375	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	ARF1 controls Rac1 signaling to regulate migration of MDA-MB-231 invasive breast_cancer cells .
11481345	0	Rac1	102,106	ARF6	14,18	Rac1	ARF6	5879	382	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|Activation Activation|nmod|END_ENTITY	Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase_D .
17122362	0	Rac1	31,35	ARF6	11,15	Rac1	ARF6	5879	382	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Endogenous ARF6 interacts with Rac1 upon angiotensin_II stimulation to regulate membrane ruffling and cell migration .
25799492	0	Rac1	31,35	ARF6	0,4	Rac1	ARF6	5879	382	Gene	Gene	Formation|nmod|START_ENTITY Promotes|dobj|Formation Promotes|nsubj|END_ENTITY	ARF6 Promotes the Formation of Rac1 and WAVE-Dependent Ventral F-Actin Rosettes in Breast_Cancer Cells in Response to Epidermal_Growth_Factor .
18325335	0	Rac1	18,22	Affixin	0,7	Rac1	Affixin	19353(Tax:10090)	170736(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Affixin activates Rac1 via betaPIX in C2C12 myoblast .
23499910	0	Rac1	15,19	Akt2	0,4	Rac1	Akt2	5879	208	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells .
16213822	0	Rac1	95,99	Arf6	47,51	Rac1	Arf6	403955(Tax:9615)	490679(Tax:9615)	Gene	Gene	activation|nmod|START_ENTITY couples|nmod|activation couples|dobj|activation activation|amod|END_ENTITY	The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1 .
23223291	0	Rac1	82,86	Arf6	15,19	Rac1	Arf6	38146(Tax:7227)	36699(Tax:7227)	Gene	Gene	downstream|nmod|START_ENTITY controls|nmod|downstream controls|nsubj|END_ENTITY	Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B .
23223291	0	Rac1	82,86	Arfaptin	59,67	Rac1	Arfaptin	38146(Tax:7227)	41353(Tax:7227)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B .
21911940	0	Rac1	21,25	Arhgap24	0,8	Rac1	Arhgap24	19353(Tax:10090)	231532(Tax:10090)	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	Arhgap24 inactivates Rac1 in mouse podocytes , and a mutant form is associated with familial focal_segmental_glomerulosclerosis .
17599059	0	Rac1	96,100	Asef2	39,44	Rac1	Asef2	5879	221178	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of Asef2 , a guanine-nucleotide exchange factor specific for Rac1 and Cdc42 .
22745590	0	Rac1	100,104	BART	0,4	Rac1	BART	5879	23568	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	BART inhibits pancreatic_cancer cell invasion by Rac1 inactivation through direct binding to active Rac1 .
22745590	0	Rac1	49,53	BART	0,4	Rac1	BART	5879	23568	Gene	Gene	inactivation|amod|START_ENTITY invasion|nmod|inactivation inhibits|dobj|invasion inhibits|nsubj|END_ENTITY	BART inhibits pancreatic_cancer cell invasion by Rac1 inactivation through direct binding to active Rac1 .
22767509	0	Rac1	44,48	BCR	40,43	Rac1	BCR	19353(Tax:10090)	110279(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein , a substrate of PTPRT .
15247305	0	Rac1	36,40	Bam32	20,25	Rac1	Bam32	5879	27071	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism .
14557270	0	Rac1	56,60	Basic_fibroblast_growth_factor	0,30	Rac1	Basic fibroblast growth factor	363875(Tax:10116)	54250(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway .
21406564	0	Rac1	56,60	Calpain-6	0,9	Rac1	Calpain-6	19353(Tax:10090)	12338(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Calpain-6 , a microtubule-stabilizing protein , regulates Rac1 activity and cell motility through interaction with GEF-H1 .
24625804	0	Rac1	77,81	Caveolin-1	0,10	Rac1	Caveolin-1	5879	857	Gene	Gene	activation|compound|START_ENTITY regulation|nmod|activation invasion|nmod|regulation mediates|dobj|invasion mediates|nsubj|END_ENTITY	Caveolin-1 mediates Salmonella invasion via the regulation of SopE-dependent Rac1 activation and actin reorganization .
9808620	0	Rac1	14,18	DOCK180	49,56	Rac1	DOCK180	5879	1793	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|protein protein|appos|END_ENTITY	Activation of Rac1 by a Crk SH3-binding protein , DOCK180 .
17403664	0	Rac1	48,52	Def-6	0,5	Rac1	Def-6	5879	50619	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Def-6 , a guanine_nucleotide exchange factor for Rac1 , interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation .
22080864	0	Rac1	14,18	Dock180	55,62	Rac1	Dock180	19353(Tax:10090)	330662(Tax:10090)	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Activation of Rac1 by Src-dependent phosphorylation of Dock180 -LRB- Y1811 -RRB- mediates PDGFRa-stimulated glioma_tumorigenesis in mice and humans .
15689411	0	Rac1	52,56	E-cadherin	25,35	Rac1	E-cadherin	5879	999	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|trafficking trafficking|nmod|END_ENTITY	Polarized trafficking of E-cadherin is regulated by Rac1 and Cdc42 in Madin-Darby canine kidney cells .
16682529	0	Rac1	51,55	E-cadherin	0,10	Rac1	E-cadherin	363875(Tax:10116)	83502(Tax:10116)	Gene	Gene	proliferation|nmod|START_ENTITY stimulates|dobj|proliferation stimulates|nsubj|engagement engagement|amod|END_ENTITY	E-cadherin engagement stimulates proliferation via Rac1 .
19584084	0	Rac1	0,4	E-cadherin	88,98	Rac1	E-cadherin	5879	999	Gene	Gene	contribute|nsubj|START_ENTITY contribute|nmod|phenotype phenotype|acl|associated associated|nmod|mutation mutation|amod|END_ENTITY	Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation .
20368760	0	Rac1	40,44	E-cadherin	20,30	Rac1	E-cadherin	403955(Tax:9615)	442858(Tax:9615)	Gene	Gene	Response|compound|START_ENTITY Response|compound|END_ENTITY	Lateral Mobility of E-cadherin Enhances Rac1 Response in Epithelial Cells .
15046862	0	Rac1	16,20	ERK1/2	57,63	Rac1	ERK1/2	363875(Tax:10116)	50689;116590	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	PACAP activates Rac1 and synergizes with NGF to activate ERK1/2 , thereby inducing neurite outgrowth in PC12 cells .
25963818	0	Rac1	69,73	Formin-like_2	41,54	Rac1	Formin-like 2	5879	114793	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Junctional actin assembly is mediated by Formin-like_2 downstream of Rac1 .
21406564	0	Rac1	56,60	GEF-H1	113,119	Rac1	GEF-H1	19353(Tax:10090)	16800(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nmod|interaction interaction|nmod|END_ENTITY	Calpain-6 , a microtubule-stabilizing protein , regulates Rac1 activity and cell motility through interaction with GEF-H1 .
26751560	0	Rac1	60,64	Glutaminase_2	0,13	Rac1	Glutaminase 2	5879	27165	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Glutaminase_2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis .
23148778	0	Rac1	19,23	HGF	0,3	Rac1	HGF	5879	3082	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	HGF stimulation of Rac1 signaling enhances pharmacological correction of the most prevalent cystic_fibrosis mutant F508del-CFTR .
12719791	0	Rac1	92,96	HIF-1	33,38	Rac1	HIF-1	5879	3091	Gene	Gene	involvement|nmod|START_ENTITY expression|dep|involvement mediated|dobj|expression mediated|nsubj|END_ENTITY	Reactive oxygen species modulate HIF-1 mediated PAI-1 expression : involvement of the GTPase Rac1 .
19165496	0	Rac1	0,4	HIF-1	15,20	Rac1	HIF-1	5879	3091	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Rac1 activates HIF-1 in retinal_pigment_epithelium cells under hypoxia .
22553600	0	Rac1	0,4	HIF-1	15,20	Rac1	HIF-1	5879	3091	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Rac1 activates HIF-1 in laser induced choroidal_neovascularization .
27018294	0	Rac1	9,13	HIF-1	16,21	Rac1	HIF-1	5879	3091	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|crosstalk crosstalk|compound|END_ENTITY	Temporal Rac1 - HIF-1 crosstalk modulates hypoxic survival of aged neurons .
20001745	0	Rac1	25,29	HIF-1alpha	43,53	Rac1	HIF-1alpha	5879	3091	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of Rac1 and PAK-1 by HIF-1alpha : a positive-feedback loop promoting pulmonary_vascular_remodeling .
21961005	0	Rac1	0,4	IGF-I	94,99	Rac1	IGF-I	5879	3479	Gene	Gene	Cells|nsubj|START_ENTITY Cells|nmod|END_ENTITY	Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast_Cancer Cells in Response to IGF-I .
16982892	0	Rac1	0,4	IL-23_p19	53,62	Rac1	IL-23 p19	5879	51561	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Rac1 negatively regulates lipopolysaccharide-induced IL-23_p19 expression in human macrophages and dendritic cells and NF-kappaB_p65 trans activation plays a novel role .
11470914	0	Rac1	0,4	IL-6	44,48	Rac1	IL-6	5879	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Rac1 mediates STAT3 activation by autocrine IL-6 .
21885850	0	Rac1	74,78	IQ_domain_GTPase-activating_protein_1	24,61	Rac1	IQ domain GTPase-activating protein 1	5879	8826	Gene	Gene	activate|dobj|START_ENTITY END_ENTITY|xcomp|activate	Angiopoietin-1 requires IQ_domain_GTPase-activating_protein_1 to activate Rac1 and promote endothelial barrier defense .
23478800	0	Rac1	24,28	Janus_tyrosine_kinase_2	132,155	Rac1	Janus tyrosine kinase 2	5879	3717	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Cucurbitacin_I inhibits Rac1 activation in breast_cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus_tyrosine_kinase_2 and P-Rex1 .
16257181	0	Rac1	31,35	K-Ras	10,15	Rac1	K-Ras	5879	3845	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic_carcinoma cells through activation of p38 .
20719958	0	Rac1	60,64	MAP1B	0,5	Rac1	MAP1B	19353(Tax:10090)	17755(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY modulating|dobj|activity regulates|advcl|modulating regulates|nsubj|END_ENTITY	MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity .
25002679	0	Rac1	0,4	MCAK	27,31	Rac1	MCAK	5879	11004	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	Rac1 and Aurora_A regulate MCAK to polarize microtubule growth in migrating endothelial cells .
21325632	0	Rac1	16,20	MYADM	0,5	Rac1	MYADM	5879	91663	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration .
24186093	0	Rac1	21,25	Mena	0,4	Rac1	Mena	19353(Tax:10090)	13800(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Mena associates with Rac1 and modulates connexin_43 remodeling in cardiomyocytes .
22479308	0	Rac1	82,86	Mtss1	0,5	Rac1	Mtss1	5879	9788	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1 .
20363326	0	Rac1	0,4	NS5	79,82	Rac1	NS5	5879	5894	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	Rac1 and Scribble are targets for the arrest of neurite outgrowth by TBE virus NS5 .
11844789	0	Rac1	0,4	Netrin-1	103,111	Rac1	Netrin-1	19353(Tax:10090)	18208(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|outgrowth outgrowth|acl|induced induced|nmod|DCC DCC|compound|END_ENTITY	Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC -LRB- deleted_in_colorectal_cancer -RRB- in N1E-115 neuroblastoma cells .
18502673	0	Rac1	70,74	P-Rex1	30,36	Rac1	P-Rex1	19353(Tax:10090)	277360(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Lack of a significant role of P-Rex1 , a major regulator of macrophage Rac1 activation and chemotaxis , in atherogenesis .
26112412	0	Rac1	159,163	P-Rex1	117,123	Rac1	P-Rex2	5879	80243	Gene	Gene	Activation|compound|START_ENTITY Basis|nmod|Activation Reveals|dobj|Basis Substrate|acl:relcl|Reveals Substrate|dep|END_ENTITY	The Phosphatidylinositol -LRB- 3,4,5 -RRB- - trisphosphate-dependent Rac Exchanger 1 : Ras-related C3 Botulinum Toxin Substrate 1 -LRB- P-Rex1 : Rac1 -RRB- Complex Reveals the Basis of Rac1 Activation in Breast_Cancer Cells .
25901126	0	Rac1	51,55	P-glycoprotein	21,35	Rac1	P-glycoprotein	5879	5243	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric_cancer cells .
15046862	0	Rac1	16,20	PACAP	0,5	Rac1	PACAP	363875(Tax:10116)	24166(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	PACAP activates Rac1 and synergizes with NGF to activate ERK1/2 , thereby inducing neurite outgrowth in PC12 cells .
11803464	0	Rac1	0,4	PI3K	57,61	Rac1	PI3K	5879	5293	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|activation activation|nmod|END_ENTITY	Rac1 and RhoG promote cell survival by the activation of PI3K and Akt , independently of their ability to stimulate JNK and NF-kappaB .
21980400	0	Rac1	21,25	PI3K	0,4	Rac1	PI3K	5879	5293	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1a expression in MCF-7 breast_cancer cells .
20637541	0	Rac1	115,119	PTHrP	0,5	Rac1	PTHrP	5879	5744	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	PTHrP promotes colon_cancer cell migration and invasion in an integrin a6b4-dependent manner through activation of Rac1 .
19738201	0	Rac1	91,95	RCC2	63,67	Rac1	RCC2	5879	55920	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6 .
23353182	0	Rac1	41,45	Rab35	0,5	Rac1	Rab35	5879	11021	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast_cancer cells .
22467863	0	Rac1	64,68	Radixin	0,7	Rac1	Radixin	5879	5962	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Radixin regulates cell migration and cell-cell adhesion through Rac1 .
22820503	0	Rac1	27,31	RalA	8,12	Rac1	RalA	19353(Tax:10090)	56044(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells .
26205497	0	Rac1	28,32	RalA	9,13	Rac1	RalA	19353(Tax:10090)	56044(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Role for RalA downstream of Rac1 in skeletal muscle insulin signalling .
11279039	0	Rac1	46,50	RhoA	0,4	Rac1	RhoA	363875(Tax:10116)	117273(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY factor-induced|dobj|activation inhibits|ccomp|factor-induced inhibits|nsubj|END_ENTITY	RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway .
15736231	0	Rac1	18,22	RhoA	0,4	Rac1	RhoA	363875(Tax:10116)	117273(Tax:10116)	Gene	Gene	Cdc42|appos|START_ENTITY Cdc42|compound|END_ENTITY	RhoA , RhoB , RhoC , Rac1 , Cdc42 , and Tc10 mRNA levels in spinal cord , sensory ganglia , and corticospinal tract neurons and long-lasting specific changes following spinal_cord_injury .
17300916	0	Rac1	85,89	RhoA	93,97	Rac1	RhoA	5879	387	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Regulator_of_G-protein_signalling_3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation .
20696841	0	Rac1	29,33	RhoA	0,4	Rac1	RhoA	363875(Tax:10116)	117273(Tax:10116)	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor alpha and stimulation of vascular smooth muscle cell migration .
25107911	0	Rac1	115,119	RhoA	13,17	Rac1	RhoA	5879	387	Gene	Gene	Activity|amod|START_ENTITY Stimulation|nmod|Activity IL-1b|nmod|Stimulation Contributes|xcomp|IL-1b Contributes|nsubj|END_ENTITY	Unprenylated RhoA Contributes to IL-1b Hypersecretion in Mevalonate_Kinase Deficiency Model through Stimulation of Rac1 Activity .
12376551	0	Rac1	30,34	RhoG	0,4	Rac1	RhoG	5879	391	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	RhoG signals in parallel with Rac1 and Cdc42 .
12879077	0	Rac1	15,19	RhoG	0,4	Rac1	RhoG	5879	391	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo .
9614181	0	Rac1	60,64	RhoG	0,4	Rac1	RhoG	363875(Tax:10116)	308875(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY pathway|acl:relcl|activates controls|dobj|pathway controls|nsubj|GTPase GTPase|compound|END_ENTITY	RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs .
25901126	0	Rac1	51,55	RhoGDI2	0,7	Rac1	RhoGDI2	5879	397	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric_cancer cells .
15475011	0	Rac1	27,31	S6K1	46,50	Rac1	S6K1	363875(Tax:10116)	83840(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Hydrogen_peroxide mediates Rac1 activation of S6K1 .
21658605	0	Rac1	50,54	SH3BP1	0,6	Rac1	SH3BP1	5879	23616	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	SH3BP1 , an exocyst-associated RhoGAP , inactivates Rac1 at the front to drive cell motility .
24434436	0	Rac1	17,21	SNTA1	8,13	Rac1	SNTA1	5879	6640	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Role of SNTA1 in Rac1 activation , modulation of ROS generation , and migratory potential of human breast_cancer cells .
18774104	0	Rac1	39,43	STAT1	62,67	Rac1	STAT1	100627149	396655(Tax:9823)	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial_fibrillation .
11470914	0	Rac1	0,4	STAT3	14,19	Rac1	STAT3	5879	6774	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	Rac1 mediates STAT3 activation by autocrine IL-6 .
25529012	0	Rac1	81,85	Semaphorin-3F	0,13	Rac1	Semaphorin-3F	5879	6405	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Semaphorin-3F suppresses the stemness of colorectal_cancer cells by inactivating Rac1 .
19463088	0	Rac1	21,25	T-cadherin	0,10	Rac1	T-cadherin	5879	1012	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability .
16203995	0	Rac1	20,24	Tiam1	42,47	Rac1	Tiam1	5879	7074	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Ras activation of a Rac1 exchange factor , Tiam1 , mediates neurotrophin-3-induced Schwann cell migration .
17440041	0	Rac1	4,8	Tiam1	44,49	Rac1	Tiam1	5879	7074	Gene	Gene	development|amod|START_ENTITY development|compound|END_ENTITY	The Rac1 guanine_nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development .
12566226	0	Rac1	42,46	Transforming_growth_factor_beta	0,31	Rac1	Transforming growth factor beta	5879	7040	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Transforming_growth_factor_beta activates Rac1 and Cdc42Hs GTPases and the JNK pathway in skeletal muscle cells .
11146652	0	Rac1	4,8	Trio	42,46	Rac1	Trio	5879	7204	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The Rac1 - and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin .
18212043	0	Rac1	31,35	Trio	0,4	Rac1	Trio	19353(Tax:10090)	223435(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance .
15647276	0	Rac1	43,47	Tumor_necrosis_factor_alpha	0,27	Rac1	Tumor necrosis factor alpha	19353(Tax:10090)	21926(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity stimulation|compound|END_ENTITY	Tumor_necrosis_factor_alpha stimulation of Rac1 activity .
26224100	0	Rac1	47,51	VAV2	0,4	Rac1	VAV2	363875(Tax:10116)	296603(Tax:10116)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	VAV2 , a guanine_nucleotide exchange factor for Rac1 , regulates glucose-stimulated insulin secretion in pancreatic beta cells .
16440308	0	Rac1	77,81	VEGF	36,40	Rac1	VEGF	19353(Tax:10090)	22339(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	c-Jun kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA .
19404567	0	Rac1	90,94	VEGF	14,18	Rac1	VEGF	5879	7422	Gene	Gene	activation|amod|START_ENTITY pathway|nmod|activation increased|dep|pathway increased|ccomp|induces induces|nsubj|END_ENTITY	How increased VEGF induces glomerular_hyperpermeability : a potential signaling pathway of Rac1 activation .
21030561	0	Rac1	7,11	VEGF	32,36	Rac1	VEGF	5879	7422	Gene	Gene	improves|nsubj|START_ENTITY improves|dobj|architecture architecture|compound|END_ENTITY	Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak : mechanistic similarities with angiopoietin-1 .
10982832	0	Rac1	15,19	Vav2	0,4	Rac1	Vav2	5879	7410	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Vav2 activates Rac1 , Cdc42 , and RhoA downstream from growth factor receptors but not beta1 integrins .
17686471	0	Rac1	13,17	Vav2	105,109	Rac1	Vav2	5879	7410	Gene	Gene	activation|amod|START_ENTITY regulated|nsubjpass|activation regulated|nmod|END_ENTITY	VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine_nucleotide exchange factor Vav2 .
17996485	0	Rac1	51,55	Vav2	10,14	Rac1	Vav2	5879	7410	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral_squamous_cell_carcinoma .
23931752	0	Rac1	51,55	Vav3	43,47	Rac1	Vav3	19353(Tax:10090)	57257(Tax:10090)	Gene	Gene	activator|amod|START_ENTITY END_ENTITY|appos|activator	Chronic sympathoexcitation through loss of Vav3 , a Rac1 activator , results in divergent effects on metabolic_syndrome and obesity depending on diet .
26369929	0	Rac1	87,91	Vimentin	0,8	Rac1	Vimentin	19353(Tax:10090)	22352(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1 .
17122362	0	Rac1	31,35	angiotensin_II	41,55	Rac1	angiotensin II	5879	183	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|amod|END_ENTITY	Endogenous ARF6 interacts with Rac1 upon angiotensin_II stimulation to regulate membrane ruffling and cell migration .
19861492	0	Rac1	56,60	betaPIX	88,95	Rac1	betaPIX	19353(Tax:10090)	54126(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX .
11050083	0	Rac1	30,34	c-Jun_N-terminal_kinase	56,79	Rac1	c-Jun N-terminal kinase	5879	5599	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Implication of a small GTPase Rac1 in the activation of c-Jun_N-terminal_kinase and heat_shock_factor in response to heat_shock .
23197717	0	Rac1	0,4	cAMP	47,51	Rac1	cAMP	19353(Tax:10090)	12796(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Rac1 controls Schwann cell myelination through cAMP and NF2/merlin .
26842651	0	Rac1	35,39	caveolin-1	8,18	Rac1	caveolin-1	5879	857	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	A novel caveolin-1 / p85a/Rab5/Tiam1 / Rac1 signaling axis in tumor cell migration and invasion .
9572733	0	Rac1	8,12	collagenase-1	36,49	Rac1	collagenase-1	100339873(Tax:9986)	100009110(Tax:9986)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change .
24819662	0	Rac1	32,36	dock180	12,19	Rac1	dock180	5879	1793	Gene	Gene	activity|amod|START_ENTITY regulate|dobj|activity END_ENTITY|xcomp|regulate	Elmo1 helps dock180 to regulate Rac1 activity and cell migration_of_ovarian_cancer .
19852956	0	Rac1	10,14	gp130	24,29	Rac1	gp130	19353(Tax:10090)	16195(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Activated Rac1 requires gp130 for Stat3 activation , cell proliferation and migration .
15178328	0	Rac1	0,4	interferon_regulatory_factor-3	79,109	Rac1	interferon regulatory factor-3	5879	3661	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon_regulatory_factor-3 .
21590706	0	Rac1	13,17	kindlin-2	32,41	Rac1	kindlin-2	19353(Tax:10090)	218952(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Mediation of Rac1 activation by kindlin-2 : an essential function in osteoblast adhesion , spreading , and proliferation .
21474067	0	Rac1	0,4	mTORC1	31,37	Rac1	mTORC1	5879	382056(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size .
25530132	0	Rac1	75,79	miR-142	0,7	Rac1	miR-142	5879	406934	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	miR-142 acts as a tumor suppressor in osteosarcoma cell lines by targeting Rac1 .
25214035	0	Rac1	73,77	miR-146a	0,8	Rac1	miR-146a	5879	406938	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	miR-146a functions as a tumor suppressor in prostate_cancer by targeting Rac1 .
15569826	0	Rac1	113,117	mitogen-activated_protein_kinase_phosphatase-1	35,81	Rac1	mitogen-activated protein kinase phosphatase-1	5879	1843	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Atrial natriuretic peptide induces mitogen-activated_protein_kinase_phosphatase-1 in human endothelial cells via Rac1 and NAD -LRB- P -RRB- H oxidase/Nox2-activation .
12149262	0	Rac1	129,133	netrin-1	38,46	Rac1	netrin-1	5879	18208(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY couples|nmod|activation couples|dobj|DCC DCC|amod|END_ENTITY	The adaptor protein Nck-1 couples the netrin-1 receptor DCC -LRB- deleted in colorectal_cancer -RRB- to the activation of the small GTPase Rac1 through an atypical mechanism .
19755150	0	Rac1	62,66	netrin-1	74,82	Rac1	netrin-1	19353(Tax:10090)	18208(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth .
10652294	0	Rac1	0,4	nuclear_factor_kappaB	37,58	Rac1	nuclear factor kappaB	5879	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Rac1 regulates interleukin_1-induced nuclear_factor_kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression .
23759924	0	Rac1	51,55	p62	77,80	Rac1	p62	19353(Tax:10090)	18412(Tax:10090)	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway .
20339116	0	Rac1	109,113	phosphatidylinositol_3-kinase	66,95	Rac1	phosphatidylinositol 3-kinase	363875(Tax:10116)	298947(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol_3-kinase / Akt-mediated Rac1 activation .
19388051	0	Rac1	164,168	plexin-B1	108,117	Rac1	plexin-B1	5879	5364	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Thermodynamic characterization of two homologous protein complexes : associations of the semaphorin receptor plexin-B1 RhoGTPase binding domain with Rnd1 and active Rac1 .
24006490	0	Rac1	82,86	srGAP1	0,6	Rac1	srGAP1	5879	57522	Gene	Gene	activity|amod|START_ENTITY modulating|dobj|activity regulates|advcl|modulating regulates|nsubj|END_ENTITY	srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity .
15231571	0	Rac1	17,21	vGPCR	70,75	Rac1	vGPCR	5879	4961465(Tax:37296)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	The small GTPase Rac1 links the Kaposi_sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia .
18813837	0	Rac1	91,95	vasodilator-stimulated_phosphoprotein	49,86	Rac1	vasodilator-stimulated phosphoprotein	5879	7408	Gene	Gene	pathway|amod|START_ENTITY regulation|nmod|pathway regulation|nmod|END_ENTITY	Positive regulation of migration and invasion by vasodilator-stimulated_phosphoprotein via Rac1 pathway in human breast_cancer cells .
20307526	0	Rac1	130,134	vasodilator-stimulated_phosphoprotein	88,125	Rac1	vasodilator-stimulated phosphoprotein	5879	7408	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Icariin exterts negative effects on human gastric_cancer cell invasion and migration by vasodilator-stimulated_phosphoprotein via Rac1 pathway .
22345572	0	Rac1_and_matrix_metalloproteinase-2	82,117	CXCR4	0,5	Rac1 and matrix metalloproteinase-2	CXCR4	363875;81686	60628(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1_and_matrix_metalloproteinase-2 .
12176041	0	Rac2	53,57	DOCK2	0,5	Rac2	DOCK2	5880	1794	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription .
16243036	0	Rac2	20,24	P-Rex1	0,6	Rac2	P-Rex1	19354(Tax:10090)	277360(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|nsubj|END_ENTITY	P-Rex1 is a primary Rac2 guanine_nucleotide exchange factor in mouse neutrophils .
16987989	0	Rac2	102,106	Rac2	53,57	Rac2	Rac2	5880	5880	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells : a role for Rac2 in VSMC activation .
16987989	0	Rac2	53,57	Rac2	102,106	Rac2	Rac2	5880	5880	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells : a role for Rac2 in VSMC activation .
17575012	0	Rac2	58,62	cyclooxygenase-2	14,30	Rac2	cyclooxygenase-2	19354(Tax:10090)	19225(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages .
11756406	0	Rac3	17,21	CIB	66,69	Rac3	CIB	5881	10519	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha -LRB- IIb -RRB- beta -LRB- 3 -RRB- - mediated adhesion and spreading .
11956649	0	Rac3	32,36	NRBP	42,46	Rac3	NRBP	5881	29959	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the small GTPase Rac3 with NRBP , a protein with a kinase-homology domain .
11312657	0	Rack1	0,5	Nef	18,21	Rack1	Nef	10399	156110(Tax:11676)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor .
21860413	0	Rack1	0,5	c-Jun	41,46	Rack1	c-Jun	10399	3725	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation .
23383325	0	Rad17	6,11	Rad9	0,4	Rad17	Rad9	5884	5883	Gene	Gene	play|nsubj|START_ENTITY play|advmod|END_ENTITY	Rad9 , Rad17 , TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance .
24923443	0	Rad17	42,47	Ubiquitin-specific_peptidase_20	0,31	Rad17	Ubiquitin-specific peptidase 20	5884	10868	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Ubiquitin-specific_peptidase_20 regulates Rad17 stability , checkpoint_kinase_1 phosphorylation and DNA repair by homologous recombination .
16611994	0	Rad18	0,5	DNA_polymerase_kappa	16,36	Rad18	DNA polymerase kappa	58186(Tax:10090)	56626(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Rad18 regulates DNA_polymerase_kappa and is required for recovery from S-phase checkpoint-mediated arrest .
22391204	0	Rad18	0,5	E2F3	37,41	Rad18	E2F3	56852	1871	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Rad18 is a transcriptional target of E2F3 .
16105547	0	Rad23	52,57	HHR23A	0,6	Rad23	HHR23A	856674(Tax:4932)	5886	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	HHR23A , a human homolog of Saccharomyces_cerevisiae Rad23 , regulates xeroderma_pigmentosum_C protein and is required for nucleotide excision repair .
21047872	0	Rad23	81,86	hHR23A	88,94	Rad23	hHR23A	856674(Tax:4932)	5886	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The crystal structure of the ubiquitin-like -LRB- UbL -RRB- domain of human homologue A of Rad23 -LRB- hHR23A -RRB- protein .
9784390	0	Rad25	31,36	Ssl2	25,29	Rad25	Ssl2	854663(Tax:4932)	854663(Tax:4932)	Gene	Gene	requirement|appos|START_ENTITY requirement|nmod|END_ENTITY	The requirement of yeast Ssl2 -LRB- Rad25 -RRB- for the repair of cisplatin-damaged DNA .
24674623	0	Rad2p	27,32	PCNA	4,8	Rad2p	PCNA	2237	5111	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The PCNA binding domain of Rad2p plays a role in mutagenesis by modulating the cell cycle in response to DNA damage .
20096653	0	Rad5	14,18	HLTF	44,48	Rad5	Rad6	850719(Tax:4932)	852822(Tax:4932)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of yeast Rad5 and its human orthologs , HLTF and SHPRH in DNA damage tolerance .
23142547	0	Rad5	121,125	Rev1	28,32	Rad5	Rev1	850719(Tax:4932)	854527(Tax:4932)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|function function|nmod|END_ENTITY	A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5 .
27001510	0	Rad5	29,33	Rev1	97,101	Rad5	Rev1	850719(Tax:4932)	854527(Tax:4932)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of budding yeast Rad5 in translesion_DNA_synthesis through physical interaction with Rev1 .
11470800	0	Rad50	17,22	Mre11	25,30	Rad50	Mre11	855471(Tax:4932)	855264(Tax:4932)	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	Structure of the Rad50 x Mre11 DNA repair complex from Saccharomyces_cerevisiae by electron microscopy .
8756642	0	Rad50	6,11	Mre11	48,53	Rad50	Mre11	10111	4361	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	Human Rad50 is physically associated with human Mre11 : identification of a conserved multiprotein complex implicated in recombinational DNA repair .
10843985	0	Rad51	83,88	BRCA1	38,43	Rad51	BRCA1	19361(Tax:10090)	12189(Tax:10090)	Gene	Gene	assembly|nmod|START_ENTITY required|nmod|assembly required|nsubjpass|END_ENTITY	The breast_cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin .
20979543	0	Rad51	81,86	BRCA1	0,5	Rad51	BRCA1	5888	672	Gene	Gene	reduces|iobj|START_ENTITY reduces|nsubj|heterozygosity heterozygosity|compound|END_ENTITY	BRCA1 and BRCA2 heterozygosity in embryonic stem cells reduces radiation-induced Rad51 focus formation but is not associated with radiosensitivity .
21103343	0	Rad51	71,76	BRCA1	55,60	Rad51	BRCA1	5888	672	Gene	Gene	recruitment|amod|START_ENTITY regulates|dobj|recruitment regulates|nsubj|proteolysis proteolysis|nmod|END_ENTITY	PI 3 kinase related kinases-independent proteolysis of BRCA1 regulates Rad51 recruitment during genotoxic stress in human cells .
21708019	0	Rad51	15,20	BRCA1	53,58	Rad51	BRCA1	5888	672	Gene	Gene	polymorphism|amod|START_ENTITY Association|nmod|polymorphism repair|nsubj|Association repair|nmod|carriers carriers|nummod|END_ENTITY	Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast_cancer risk .
9008167	0	Rad51	26,31	BRCA1	15,20	Rad51	BRCA1	5888	672	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of BRCA1 with Rad51 in mitotic and meiotic cells .
10446958	0	Rad51	61,66	BRCA2	0,5	Rad51	BRCA2	5888	675	Gene	Gene	complex|amod|START_ENTITY assembly|nmod|complex ionizing|dobj|assembly required|advcl|ionizing required|nsubjpass|END_ENTITY	BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo .
12504001	0	Rad51	12,17	BRCA2	0,5	Rad51	BRCA2	5888	675	Gene	Gene	keeps|dobj|START_ENTITY keeps|nsubj|END_ENTITY	BRCA2 keeps Rad51 in line .
12941707	0	Rad51	21,26	BRCA2	95,100	Rad51	BRCA2	5888	675	Gene	Gene	structure|amod|START_ENTITY structure|dep|mechanisms mechanisms|nmod|assembly assembly|nmod|END_ENTITY	Full-length archaeal Rad51 structure and mutants : mechanisms for RAD51 assembly and control by BRCA2 .
14580352	0	Rad51	19,24	BRCA2	78,83	Rad51	BRCA2	5888	675	Gene	Gene	control|nmod|START_ENTITY recombinase|nsubj|control recombinase|nmod|END_ENTITY	Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2 .
17767921	0	Rad51	18,23	BRCA2	38,43	Rad51	BRCA2	177914(Tax:6239)	675	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Identification of Rad51 regulation by BRCA2 using Caenorhabditis_elegans BRCA2 and bimolecular fluorescence complementation analysis .
17767921	0	Rad51	18,23	BRCA2	73,78	Rad51	BRCA2	177914(Tax:6239)	675	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|BRCA2 BRCA2|acl|using using|dobj|END_ENTITY	Identification of Rad51 regulation by BRCA2 using Caenorhabditis_elegans BRCA2 and bimolecular fluorescence complementation analysis .
18429819	0	Rad51	42,47	BRCA2	109,114	Rad51	BRCA2	5888	675	Gene	Gene	protein|amod|START_ENTITY formation|nmod|protein Inhibition|nmod|formation derived|nsubj|Inhibition derived|nmod|BRC-motif BRC-motif|nmod|protein protein|compound|END_ENTITY	Inhibition of filament formation of human Rad51 protein by a small peptide derived from the BRC-motif of the BRCA2 protein .
19747923	0	Rad51	95,100	BRCA2	46,51	Rad51	BRCA2	5888	675	Gene	Gene	induced|nmod|START_ENTITY recombination|acl|induced affect|dobj|recombination affect|nsubj|mutations mutations|nmod|domains domains|nmod|END_ENTITY	Cancer-associated mutations in BRC domains of BRCA2 affect homologous recombination induced by Rad51 .
15657438	0	Rad51	146,151	Brca2	19,24	Rad51	Brca2	396086(Tax:9031)	374139(Tax:9031)	Gene	Gene	paralogs|amod|START_ENTITY role|nmod|paralogs support|dobj|role support|nsubj|effects effects|nmod|truncation truncation|amod|END_ENTITY	Similar effects of Brca2 truncation and Rad51 paralog_deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination .
19540122	0	Rad51	56,61	Brca2	25,30	Rad51	Brca2	5888	675	Gene	Gene	complexes|amod|START_ENTITY disassembly|nmod|complexes links|dobj|disassembly links|nsubj|terminus terminus|nmod|END_ENTITY	The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry .
9126738	0	Rad51	63,68	Brca2	85,90	Rad51	Brca2	19361(Tax:10090)	12190(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|xcomp|lacking lacking|dobj|END_ENTITY	Embryonic_lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 .
22587838	0	Rad51	60,65	HSF4	0,4	Rad51	HSF4	406487(Tax:7955)	503739(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	HSF4 is involved in DNA damage repair through regulation of Rad51 .
16186822	0	Rad51	20,25	MDC1	0,4	Rad51	MDC1	5888	9656	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MDC1 interacts with Rad51 and facilitates homologous recombination .
16215984	0	Rad51	90,95	Rad51C	31,37	Rad51	Rad51C	5888	5889	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51 .
19427856	0	Rad51	54,59	c-Abl	13,18	Rad51	c-Abl	5888	25	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Detection of c-Abl kinase-promoted phosphorylation of Rad51 by specific antibodies reveals that Y54 phosphorylation is dependent on that of Y315 .
9461559	0	Rad51	14,19	c-Abl	32,37	Rad51	c-Abl	5888	25	Gene	Gene	Regulation|nmod|START_ENTITY function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of Rad51 function by c-Abl in response to DNA damage .
18439040	0	Rad51	41,46	caspase_3	19,28	Rad51	caspase 3	5888	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Radiation enhances caspase_3 cleavage of Rad51 in BRCA2-defective cells .
15701685	0	Rad51B	24,30	Rad51C	49,55	Rad51B	Rad51C	5890	5889	Gene	Gene	localization|nmod|START_ENTITY independent|nsubj|localization independent|nmod|END_ENTITY	Nuclear localization of Rad51B is independent of Rad51C and BRCA2 .
16215984	0	Rad51C	31,37	Rad51	90,95	Rad51C	Rad51	5889	5888	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51 .
15701685	0	Rad51C	49,55	Rad51B	24,30	Rad51C	Rad51B	5889	5890	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|localization localization|nmod|END_ENTITY	Nuclear localization of Rad51B is independent of Rad51C and BRCA2 .
12853621	0	Rad51C	44,50	Xrcc3	72,77	Rad51C	Xrcc3	5889	7517	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Region and amino_acid residues required for Rad51C binding in the human Xrcc3 protein .
11606529	0	Rad52	62,67	Rad59	41,46	Rad52	Rad59	854976(Tax:4932)	851500(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing .
23170228	0	Rad52	31,36	Rad59	0,5	Rad52	Rad59	854976(Tax:4932)	851500(Tax:4932)	Gene	Gene	association|nmod|START_ENTITY regulates|dobj|association regulates|nsubj|END_ENTITY	Rad59 regulates association of Rad52 with DNA double-strand breaks .
12077133	0	Rad52	0,5	replication_protein_A	30,51	Rad52	replication protein A	5893	6117	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Rad52 protein associates with replication_protein_A -LRB- RPA -RRB- - single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation .
11331602	0	Rad53	11,16	Asf1	0,4	Rad53	Asf1	855950(Tax:4932)	853327(Tax:4932)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Asf1 links Rad53 to control of chromatin assembly .
15024067	0	Rad53	14,19	Mdt1	0,4	Rad53	Mdt1	855950(Tax:4932)	852229(Tax:4932)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Mdt1 , a novel Rad53 FHA1 domain-interacting protein , modulates DNA damage tolerance and G -LRB- 2 -RRB- / M cell cycle progression in Saccharomyces_cerevisiae .
16365046	0	Rad53	36,41	Mec1	90,94	Rad53	Mec1	11200	545	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Activation of the checkpoint kinase Rad53 by the phosphatidyl_inositol kinase-like kinase Mec1 .
24376557	0	Rad54	45,50	PCNA	4,8	Rad54	PCNA	8438	5111	Gene	Gene	sequence|nmod|START_ENTITY sequence|compound|END_ENTITY	The PCNA interaction protein box sequence in Rad54 is an integral part of its ATPase domain and is required for efficient DNA repair and recombination .
11606529	0	Rad59	41,46	Rad52	62,67	Rad59	Rad52	851500(Tax:4932)	854976(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing .
23170228	0	Rad59	0,5	Rad52	31,36	Rad59	Rad52	851500(Tax:4932)	854976(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|association association|nmod|END_ENTITY	Rad59 regulates association of Rad52 with DNA double-strand breaks .
17050667	0	Rad6B	62,67	beta-catenin	32,44	Rad6B	beta-catenin	7320	1499	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Essential role of T-cell_factor / beta-catenin in regulation of Rad6B : a potential mechanism for Rad6B overexpression in breast_cancer cells .
25300486	0	Rad9	0,4	Aft1	20,24	Rad9	Aft1	851803(Tax:4932)	852809(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. _ cerevisiae .
23383325	0	Rad9	0,4	Rad17	6,11	Rad9	Rad17	5883	5884	Gene	Gene	play|advmod|START_ENTITY play|nsubj|END_ENTITY	Rad9 , Rad17 , TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance .
25637499	0	Rad9	20,24	Sgs1	10,14	Rad9	Sgs1	851803(Tax:4932)	855228(Tax:4932)	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection .
22467863	0	Radixin	0,7	Rac1	64,68	Radixin	Rac1	5962	5879	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Radixin regulates cell migration and cell-cell adhesion through Rac1 .
17172455	0	Rae1	0,4	NuMA	22,26	Rae1	NuMA	8480	4926	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Rae1 interaction with NuMA is required for bipolar spindle formation .
12730952	0	Raf	76,79	14-3-3gamma	0,11	Raf	14-3-3gamma	22882	7532	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	14-3-3gamma is upregulated by in vitro ischemia and binds to protein kinase Raf in primary cultures of astrocytes .
10576742	0	Raf	34,37	Akt	41,44	Raf	Akt	22882	207	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and regulation of Raf by Akt -LRB- protein kinase B -RRB- .
14676826	0	Raf	47,50	Bim	8,11	Raf	Bim	22882	10018	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of Bim in the survival pathway induced by Raf in epithelial cells .
16086581	0	Raf	27,30	Jun-N-terminal_kinase	44,65	Raf	Jun-N-terminal kinase	22882	5599	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Functional interactions of Raf and MEK with Jun-N-terminal_kinase -LRB- JNK -RRB- result in a positive feedback loop on the oncogenic Ras signaling pathway .
17332339	0	Raf	92,95	K-Ras	0,5	Raf	K-Ras	22882	3845	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol_3-kinase signaling .
16679305	0	Raf	42,45	K-ras	0,5	Raf	K-ras	22882	3845	Gene	Gene	mutant|nmod|START_ENTITY mutant|nsubj|Asp12 Asp12|amod|END_ENTITY	K-ras Asp12 mutant neither interacts with Raf , nor signals through Erk and is less tumorigenic than K-ras Val12 .
8414521	0	Raf	60,63	MAP_kinase_kinase_kinase	34,58	Raf	MAP kinase kinase kinase	22882	4216	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Specific association of activated MAP_kinase_kinase_kinase -LRB- Raf -RRB- with the plasma membranes of ras-transformed retinal cells .
11466616	0	Raf	21,24	P21	0,3	Raf	P21	387609(Tax:10090)	12575(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	P21 -LRB- Cip1 -RRB- induced by Raf is associated with increased Cdk4 activity in hematopoietic cells .
9232600	0	Raf	23,26	Raf	82,85	Raf	Raf	31221(Tax:7227)	31221(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity regulation|nmod|END_ENTITY	Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo .
9232600	0	Raf	82,85	Raf	23,26	Raf	Raf	31221(Tax:7227)	31221(Tax:7227)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|compound|END_ENTITY	Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo .
21531053	0	Raf	82,85	STAT3	61,66	Raf	STAT3	22882	6774	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf .
2436297	0	Raf	0,3	alpha-fetoprotein	41,58	Raf	alpha-fetoprotein	387609(Tax:10090)	11576(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	Raf , a trans-acting locus , regulates the alpha-fetoprotein gene in a cell-autonomous manner .
9053849	0	Raf	53,56	c-fos	26,31	Raf	c-fos	387609(Tax:10090)	14281(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|activity activity|amod|END_ENTITY	Synergistic activation of c-fos promoter activity by Raf and Ral_GDP_dissociation_stimulator .
12042315	0	Raf	47,50	myogenin	14,22	Raf	myogenin	387609(Tax:10090)	17928(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of myogenin expression by activated Raf is not responsible for the block to avian myogenesis .
11258707	0	Raf	61,64	p53	32,35	Raf	p53	387609(Tax:10090)	22060(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|arrest arrest|compound|END_ENTITY	p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes .
7784054	0	Raf	0,3	p53	19,22	Raf	p53	387609(Tax:10090)	22060(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivo .
7760835	0	Raf-1	28,33	14-3-3	0,6	Raf-1	14-3-3	397857(Tax:8355)	10971	Gene	Gene	function|compound|START_ENTITY essential|nmod|function essential|nsubj|END_ENTITY	14-3-3 is not essential for Raf-1 function : identification of Raf-1 proteins that are biologically activated in a 14-3-3 - and Ras-independent manner .
8794890	0	Raf-1	47,52	Angiotensin_II_type_1_receptor	0,30	Raf-1	Angiotensin II type 1 receptor	24703(Tax:10116)	81638(Tax:10116)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Angiotensin_II_type_1_receptor signals through Raf-1 by a protein_kinase_C-dependent , Ras-independent mechanism .
12411479	0	Raf-1	62,67	B-cell_antigen_receptor	71,94	Raf-1	B-cell antigen receptor	396245(Tax:9031)	416952(Tax:9031)	Gene	Gene	START_ENTITY|nmod|signalling signalling|amod|END_ENTITY	Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell_antigen_receptor signalling .
10400418	0	Raf-1	92,97	Bcl-2	98,103	Raf-1	Bcl-2	5894	596	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|compound|END_ENTITY	Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1 / Bcl-2 phosphorylation and apoptosis in leukemia cells .
12488548	0	Raf-1	120,125	Bcl-2	72,77	Raf-1	Bcl-2	5894	596	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver_cancer cell lines .
8929532	0	Raf-1	33,38	Bcl-2	0,5	Raf-1	Bcl-2	5894	596	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Bcl-2 targets the protein kinase Raf-1 to mitochondria .
20807437	0	Raf-1	45,50	EGF	0,3	Raf-1	EGF	110157(Tax:10090)	13645(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	EGF regulates survivin stability through the Raf-1 / ERK pathway in insulin-secreting pancreatic b-cells .
11948406	0	Raf-1	40,45	ERK	92,95	Raf-1	ERK	5894	5594	Gene	Gene	kinase|compound|START_ENTITY kinase|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway .
12954639	0	Raf-1	56,61	ERK	96,99	Raf-1	ERK	5894	5594	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation .
15850570	0	Raf-1	32,37	ERK	24,27	Raf-1	ERK	5894	5594	Gene	Gene	cardiomyocytes|amod|START_ENTITY END_ENTITY|nmod|cardiomyocytes	Peroxynitrite activates ERK via Raf-1 and MEK , independently from EGF_receptor and p21Ras in H9C2 cardiomyocytes .
16172610	0	Raf-1	115,120	ERK	0,3	Raf-1	ERK	5894	5594	Gene	Gene	kinases|xcomp|START_ENTITY kinase|parataxis|kinases kinase|nsubj|MAP MAP|compound|END_ENTITY	ERK MAP kinase signaling in post-mortem brain of suicide subjects : differential regulation of upstream Raf kinases Raf-1 and B-Raf .
20212043	0	Raf-1	190,195	ERK	61,64	Raf-1	ERK	5894	5594	Gene	Gene	phosphorylation|amod|START_ENTITY levels|nmod|phosphorylation activity|nmod|levels activity|dep|END_ENTITY	Mammalian Ste20-like_kinase -LRB- Mst2 -RRB- indirectly supports Raf-1 / ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation .
20212043	0	Raf-1	55,60	ERK	61,64	Raf-1	ERK	5894	5594	Gene	Gene	supports|dobj|START_ENTITY supports|dep|activity activity|dep|END_ENTITY	Mammalian Ste20-like_kinase -LRB- Mst2 -RRB- indirectly supports Raf-1 / ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation .
20807437	0	Raf-1	45,50	ERK	51,54	Raf-1	ERK	110157(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	EGF regulates survivin stability through the Raf-1 / ERK pathway in insulin-secreting pancreatic b-cells .
25381666	0	Raf-1	199,204	ERK1/2	205,211	Raf-1	ERK1/2	5894	5595;5594	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Co-culture system of human salivary gland epithelial cells and immune cells from primary Sj gren 's syndrome patients : an in vitro approach to study the effects of Rituximab on the activation of the Raf-1 / ERK1/2 pathway .
26437446	0	Raf-1	165,170	ERK1/2	142,148	Raf-1	ERK1/2	24703(Tax:10116)	50689;116590	Gene	Gene	kinase|amod|START_ENTITY level|amod|kinase pathways|nmod|level pathways|nummod|END_ENTITY	Hydroxyflutamide affects connexin_43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells .
15141098	0	Raf-1	88,93	Erk1/2	0,6	Raf-1	Erk1/2	24703(Tax:10116)	50689;116590	Gene	Gene	crosstalk|compound|START_ENTITY crosstalk|dep|END_ENTITY	Erk1/2 phosphorylation and reactive_oxygen_species formation via nitric_oxide and Akt-1 / Raf-1 crosstalk in cultured rat cerebellar granule cells exposed to the organic solvent 1,2,4-trimethylcyclohexane .
20407018	0	Raf-1	48,53	Focal_adhesion_kinase	0,21	Raf-1	Focal adhesion kinase	110157(Tax:10090)	14083(Tax:10090)	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|appos|mediator	Focal_adhesion_kinase , a downstream mediator of Raf-1 signaling , suppresses cellular adhesion , migration , and neuroendocrine markers in BON_carcinoid cells .
7517401	0	Raf-1	0,5	Fyn	21,24	Raf-1	Fyn	5894	2534	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner .
9233777	0	Raf-1	42,47	Grb2	15,19	Raf-1	Grb2	5894	2885	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Grb2 with Sos and Ras with Raf-1 upon gamma irradiation of breast_cancer cells .
10339476	0	Raf-1	30,35	Interleukin-4	0,13	Raf-1	Interleukin-4	110157(Tax:10090)	16189(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase .
8876196	0	Raf-1	54,59	JAK2	39,43	Raf-1	JAK2	5894	3717	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner .
9371754	0	Raf-1	15,20	KSR	0,3	Raf-1	KSR	110157(Tax:10090)	16706(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	KSR stimulates Raf-1 activity in a kinase-independent manner .
8939988	0	Raf-1	21,26	Lck	75,78	Raf-1	Lck	5894	3932	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck .
25196457	0	Raf-1	131,136	Low-Density_Lipoprotein_Receptor	31,63	Raf-1	Low-Density Lipoprotein Receptor	24703(Tax:10116)	300438(Tax:10116)	Gene	Gene	Activation|compound|START_ENTITY END_ENTITY|nmod|Activation	Berberine Up-Regulates Hepatic Low-Density_Lipoprotein_Receptor through Ras-Independent but AMP-Activated Protein Kinase-Dependent Raf-1 Activation .
15618521	0	Raf-1	82,87	MST2	19,23	Raf-1	MST2	5894	6788	Gene	Gene	apoptosis|nmod|START_ENTITY Role|nmod|apoptosis Role|nmod|END_ENTITY	Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1 .
9823899	0	Raf-1	45,50	Pak3	19,23	Raf-1	Pak3	5894	5063	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338 .
14654844	0	Raf-1	56,61	Protein_kinase_C	0,16	Raf-1	Protein kinase C	5894	112476	Gene	Gene	switches|nmod|START_ENTITY switches|nsubj|END_ENTITY	Protein_kinase_C switches the Raf kinase inhibitor from Raf-1 to GRK-2 .
9416835	0	Raf-1	45,50	Protein_kinase_C-epsilon	0,24	Raf-1	Protein kinase C-epsilon	110157(Tax:10090)	18754(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Protein_kinase_C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity .
18294816	0	Raf-1	10,15	RKIP	4,8	Raf-1	RKIP	5894	5037	Gene	Gene	Protein|compound|START_ENTITY END_ENTITY|appos|Protein	The RKIP -LRB- Raf-1 Kinase Inhibitor Protein -RRB- conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK .
12551925	0	Raf-1	14,19	Raf_kinase_inhibitory_protein	80,109	Raf-1	Raf kinase inhibitory protein	5894	5037	Gene	Gene	Activation|nmod|START_ENTITY kinase|nsubj|Activation kinase|nmod|mechanism mechanism|nmod|END_ENTITY	Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf_kinase_inhibitory_protein .
15886202	0	Raf-1	40,45	Raf_kinase_inhibitory_protein	0,29	Raf-1	Raf kinase inhibitory protein	5894	5037	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Raf_kinase_inhibitory_protein regulates Raf-1 but not B-Raf kinase activation .
9450998	0	Raf-1	14,19	TNF	30,33	Raf-1	TNF	5894	7124	Gene	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|nmod|END_ENTITY	Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling .
8006597	0	Raf-1	12,17	T_cell_antigen_receptor	86,109	Raf-1	T cell antigen receptor	5894	6962	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Raf-1 in the regulation of extracellular_signal-regulated_kinase_2 by the T_cell_antigen_receptor .
10329666	0	Raf-1	90,95	Tvl-1	46,51	Raf-1	Tvl-1	110157(Tax:10090)	19727(Tax:10090)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1 .
8988053	0	Raf-1	0,5	bcl-2	6,11	Raf-1	bcl-2	5894	596	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|amod|END_ENTITY	Raf-1 / bcl-2 phosphorylation : a step from microtubule damage to cell death .
15674327	0	Raf-1	119,124	caspase-9	88,97	Raf-1	caspase-9	110157(Tax:10090)	12371(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1 .
10022854	0	Raf-1	56,61	cdc37	4,9	Raf-1	cdc37	110157(Tax:10090)	12539(Tax:10090)	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|END_ENTITY	p50 -LRB- cdc37 -RRB- acting in concert with Hsp90 is required for Raf-1 function .
8006597	0	Raf-1	12,17	extracellular_signal-regulated_kinase_2	39,78	Raf-1	extracellular signal-regulated kinase 2	5894	5594	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of Raf-1 in the regulation of extracellular_signal-regulated_kinase_2 by the T_cell_antigen_receptor .
15849194	0	Raf-1	59,64	p21-activated_Kinase_1	0,22	Raf-1	p21-activated Kinase 1	5894	5058	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	p21-activated_Kinase_1 -LRB- Pak1 -RRB- - dependent phosphorylation of Raf-1 regulates its mitochondrial localization , phosphorylation of BAD , and Bcl-2 association .
9137531	0	Raf-1	24,29	p53	41,44	Raf-1	p53	5894	7157	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Depletion of p185erbB2 , Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity .
23224762	0	Raf1	32,36	AP-2a	98,103	Raf1	AP-2a	5894	7020	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity regulation|nmod|END_ENTITY	Hepatitis_B_virus regulation of Raf1 promoter activity through activation of transcription factor AP-2a .
8978277	0	Raf1	25,29	Erythropoietin	0,14	Raf1	Erythropoietin	110157(Tax:10090)	13856(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells .
9553107	0	Raf1	50,54	Grb10	19,24	Raf1	Grb10	5894	2887	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases .
22610096	0	Raf1	84,88	RKIP	30,34	Raf1	RKIP	110157(Tax:10090)	23980(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY dimer|ccomp|controls dimer|nsubj|Raf_kinase_inhibitor_protein Raf_kinase_inhibitor_protein|appos|END_ENTITY	Raf_kinase_inhibitor_protein -LRB- RKIP -RRB- dimer formation controls its target switch from Raf1 to G_protein-coupled_receptor_kinase _ -LRB- GRK -RRB- _ 2 .
24863296	0	Raf1	53,57	RKIP	21,25	Raf1	RKIP	5894	5037	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Structural basis for RKIP binding with its substrate Raf1 kinase .
20071468	0	Raf1	47,51	Shoc2	60,65	Raf1	Shoc2	5894	8036	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein .
26527888	0	Raf1	30,34	miR-195	0,7	Raf1	miR-195	5894	406971	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	miR-195 is a key regulator of Raf1 in thyroid_cancer .
16924233	0	Raf_1	0,5	tight_junction_protein_occludin	34,65	Raf 1	tight junction protein occludin	5894	100506658	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Raf_1 represses expression of the tight_junction_protein_occludin via activation of the zinc-finger transcription factor slug .
24763848	0	Raf_Kinase_Inhibitor_Protein	14,42	RKIP	44,48	Raf Kinase Inhibitor Protein	RKIP	5037	5037	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Raf_Kinase_Inhibitor_Protein -LRB- RKIP -RRB- is a predictor of uveal_melanoma metastasis .
20028985	0	Raf_kinase_inhibitor_protein	13,41	Bcr-Abl	56,63	Raf kinase inhibitor protein	Bcr-Abl	5037	25	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Reduction of Raf_kinase_inhibitor_protein expression by Bcr-Abl contributes to chronic_myelogenous_leukemia proliferation .
15313400	0	Raf_kinase_inhibitor_protein	12,40	RKIP	42,46	Raf kinase inhibitor protein	RKIP	23980(Tax:10090)	23980(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of Raf_kinase_inhibitor_protein -LRB- RKIP -RRB- in health and disease .
25435928	0	Raf_kinase_inhibitor_protein	0,28	matrix_metalloproteinase_9	91,117	Raf kinase inhibitor protein	matrix metalloproteinase 9	5037	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|downregulating downregulating|dobj|END_ENTITY	Raf_kinase_inhibitor_protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix_metalloproteinase_9 and upregulating tissue_inhibitor_of_metalloproteinase_4 expression .
16757329	0	Raf_kinase_inhibitor_protein	0,28	raf	43,46	Raf kinase inhibitor protein	raf	5037	22882	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Raf_kinase_inhibitor_protein regulation of raf and MAPK signaling .
15886202	0	Raf_kinase_inhibitory_protein	0,29	Raf-1	40,45	Raf kinase inhibitory protein	Raf-1	5037	5894	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Raf_kinase_inhibitory_protein regulates Raf-1 but not B-Raf kinase activation .
26800264	0	Raffinose_Synthase_2	102,122	RS2	124,127	Raffinose Synthase 2	RS2	100158227(Tax:3847)	100158227(Tax:3847)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Environmental Stability of Seed Carbohydrate Profiles in Soybeans Containing Different Alleles of the Raffinose_Synthase_2 -LRB- RS2 -RRB- Gene .
20042504	0	Rag2	39,43	env	23,26	Rag2	env	19374(Tax:10090)	155971(Tax:11676)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Evolution of the HIV-1 env gene in the Rag2 - / - gammaC - / - humanized mouse model .
17078891	0	Rag2	58,62	gamma_c	65,72	Rag2	gamma c	19374(Tax:10090)	16186(Tax:10090)	Gene	Gene	START_ENTITY|dep|/ /|parataxis|END_ENTITY	HIV-1_infection and CD4 T cell depletion in the humanized Rag2 - / - gamma_c - / - -LRB- RAG-hu -RRB- mouse model .
26513018	0	Rak	12,15	BRCA1	63,68	Rak	BRCA1	2444	672	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Rak in the regulation of stability and function of BRCA1 .
22121046	0	Ral	14,17	M-Ras	0,5	Ral	M-Ras	5898	22808	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast_cancer cells .
9237623	0	Ral	139,142	Ral-binding_protein_1	85,106	Ral	Ral-binding protein 1	5898	10928	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	The post-translational modifications of Ral and Rac1 are important for the action of Ral-binding_protein_1 , a putative effector protein of Ral .
9422736	0	Ral	126,129	Ral-binding_protein_1	72,93	Ral	Ral-binding protein 1	5898	10928	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Identification and characterization of a novel protein interacting with Ral-binding_protein_1 , a putative effector protein of Ral .
26687416	0	Ral	96,99	Rlf	56,59	Ral	Rlf	5898	6018	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity .
10419502	0	Ral	83,86	fMet-Leu-Phe	13,25	Ral	fMet-Leu-Phe	5898	2357	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Differential fMet-Leu-Phe - and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils .
11889038	0	Ral-GEF	36,43	PDK1	0,4	Ral-GEF	PDK1	5900	5163	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism .
12621024	0	Ral-binding_protein_1	21,42	HSF-1	0,5	Ral-binding protein 1	HSF-1	19765(Tax:10090)	15499(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HSF-1 interacts with Ral-binding_protein_1 in a stress-responsive , multiprotein complex with HSP90 in vivo .
12621024	0	Ral-binding_protein_1	21,42	HSP90	93,98	Ral-binding protein 1	HSP90	19765(Tax:10090)	111058(Tax:10090)	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	HSF-1 interacts with Ral-binding_protein_1 in a stress-responsive , multiprotein complex with HSP90 in vivo .
9237623	0	Ral-binding_protein_1	85,106	Ral	139,142	Ral-binding protein 1	Ral	10928	5898	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	The post-translational modifications of Ral and Rac1 are important for the action of Ral-binding_protein_1 , a putative effector protein of Ral .
9422736	0	Ral-binding_protein_1	72,93	Ral	126,129	Ral-binding protein 1	Ral	10928	5898	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Identification and characterization of a novel protein interacting with Ral-binding_protein_1 , a putative effector protein of Ral .
21634118	0	RalA	7,11	Arf6	1,5	RalA	Arf6	5898	382	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	-LSB- Arf6 , RalA and BIRC5 protein expression in non_small_cell_lung_cancer -RSB- .
24768767	0	RalA	82,86	GARNL1	0,6	RalA	GARNL1	5898	253959	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	GARNL1 , a major RalGAP a subunit in skeletal muscle , regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins .
22820503	0	RalA	8,12	Rac1	27,31	RalA	Rac1	56044(Tax:10090)	19353(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells .
26205497	0	RalA	9,13	Rac1	28,32	RalA	Rac1	56044(Tax:10090)	19353(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Role for RalA downstream of Rac1 in skeletal muscle insulin signalling .
19823667	0	RalA	28,32	RalBP1	10,16	RalA	RalBP1	5898	10928	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. .
15592429	0	RalA	0,4	ZONAB	20,25	RalA	ZONAB	5898	8531	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity .
10051605	0	RalA	17,21	filamin	30,37	RalA	filamin	5898	2318	Gene	Gene	targets|compound|START_ENTITY END_ENTITY|nsubj|targets	The small GTPase RalA targets filamin to induce filopodia .
10467419	0	RalA	0,4	urokinase-type_plasminogen_activator	83,119	RalA	urokinase-type plasminogen activator	56044(Tax:10090)	18792(Tax:10090)	Gene	Gene	requirement|compound|START_ENTITY requirement|nmod|END_ENTITY	RalA requirement for v-Src - and v-Ras-induced tumorigenicity and overproduction of urokinase-type_plasminogen_activator : involvement of metalloproteases .
16964283	0	RalA	0,4	vascular_endothelial_growth_factor-C	15,51	RalA	vascular endothelial growth factor-C	5898	7424	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|amod|END_ENTITY	RalA regulates vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- synthesis in prostate_cancer cells during androgen ablation .
15511640	0	RalB	41,45	RLIP	0,4	RalB	RLIP	399470(Tax:8355)	394288(Tax:8355)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	RLIP mediates downstream signalling from RalB to the actin cytoskeleton during Xenopus early development .
19823667	0	RalBP1	10,16	RalA	28,32	RalBP1	RalA	10928	5898	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. .
18474607	0	Ralbp1	67,73	Hsf-1	0,5	Ralbp1	Hsf-1	10928	3297	Gene	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1 .
10471274	0	Ran	57,60	RCC1	104,108	Ran	RCC1	5901	1104	Gene	Gene	states|nmod|START_ENTITY states|nmod|END_ENTITY	Conformational states of the nuclear GTP-binding protein Ran and its complexes with the exchange factor RCC1 and the effector protein RanBP1 .
11336674	0	Ran	52,55	RCC1	101,105	Ran	RCC1	5901	1104	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|regulator_of_chromosome_condensation regulator_of_chromosome_condensation|appos|END_ENTITY	Structural basis for guanine_nucleotide exchange on Ran by the regulator_of_chromosome_condensation -LRB- RCC1 -RRB- .
1944575	0	Ran	44,47	RCC1	73,77	Ran	RCC1	5901	1104	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Catalysis of guanine_nucleotide exchange on Ran by the mitotic regulator RCC1 .
20565941	0	Ran	106,109	RCC1	34,38	Ran	RCC1	5901	1104	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|tail tail|nmod|END_ENTITY	The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells .
25452301	0	Ran	18,21	RCC1	54,58	Ran	RCC1	5901	1104	Gene	Gene	System|compound|START_ENTITY Disruption|nmod|System Disruption|nmod|Oxidation Oxidation|nmod|END_ENTITY	Disruption of the Ran System by Cysteine Oxidation of RCC1 .
7548002	0	Ran	25,28	RCC1	63,67	Ran	RCC1	5901	1104	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|dep|exchange exchange|acl|catalyzed catalyzed|nmod|END_ENTITY	The kinetic mechanism of Ran -- nucleotide exchange catalyzed by RCC1 .
7738003	0	Ran	32,35	RCC1	4,8	Ran	RCC1	100189578(Tax:8355)	397722(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The RCC1 protein interacts with Ran , RanBP1 , hsc70 , and a 340-kDa protein in Xenopus extracts .
8864848	0	Ran	78,81	RCC1	32,36	Ran	RCC1	5901	1104	Gene	Gene	exchange|nmod|START_ENTITY essential|nmod|exchange essential|nsubj|residues residues|nmod|END_ENTITY	Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran .
8889801	0	Ran	12,15	RCC1	0,4	Ran	RCC1	5901	1104	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	RCC1 in the Ran pathway .
20965183	0	Ran	26,29	Ran	8,11	Ran	Ran	19384(Tax:10090)	19384(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduced Ran expression in Ran -LRB- + / - -RRB- fibroblasts increases cytokine-stimulated nuclear abundance of the AP-1 subunits c-Fos and c-Jun .
20965183	0	Ran	8,11	Ran	26,29	Ran	Ran	19384(Tax:10090)	19384(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduced Ran expression in Ran -LRB- + / - -RRB- fibroblasts increases cytokine-stimulated nuclear abundance of the AP-1 subunits c-Fos and c-Jun .
8995296	0	Ran	97,100	RanGAP	128,134	Ran	RanGAP	5901	5905	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Ran-binding_protein_1 -LRB- RanBP1 -RRB- forms a ternary complex with Ran and karyopherin_beta and reduces Ran GTPase-activating protein -LRB- RanGAP -RRB- inhibition by karyopherin_beta .
16428860	0	Ran	59,62	RanGAP1	19,26	Ran	RanGAP1	5901	5905	Gene	Gene	stabilizes|nmod|START_ENTITY stabilizes|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1 .
8146159	0	Ran	55,58	RanGAP1	0,7	Ran	RanGAP1	5901	5905	Gene	Gene	activity|nmod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	RanGAP1 induces GTPase activity of nuclear Ras-related Ran .
9456312	0	Ran	50,53	RanGAP1	81,88	Ran	RanGAP1	5901	5905	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	SUMO-1 modification and its role in targeting the Ran GTPase-activating protein , RanGAP1 , to the nuclear pore complex .
11336674	0	Ran	52,55	regulator_of_chromosome_condensation	63,99	Ran	regulator of chromosome condensation	5901	1104	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Structural basis for guanine_nucleotide exchange on Ran by the regulator_of_chromosome_condensation -LRB- RCC1 -RRB- .
12661011	0	Ran-binding_protein_2	21,42	RANBP2	44,50	Ran-binding protein 2	RANBP2	5903	5903	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fusion of ALK to the Ran-binding_protein_2 -LRB- RANBP2 -RRB- gene in inflammatory myofibroblastic_tumor .
11353387	0	Ran-binding_protein_2	61,82	RanBP2	84,90	Ran-binding protein 2	RanBP2	19386(Tax:10090)	19386(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization , expression , and localization of murine Ran-binding_protein_2 -LRB- RanBP2 -RRB- gene .
11932251	0	Ran-binding_protein_3	0,21	Crm1	28,32	Ran-binding protein 3	Crm1	8498	7514	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Ran-binding_protein_3 links Crm1 to the Ran guanine_nucleotide exchange factor .
10330396	0	RanBP1	11,17	CRM1	36,40	RanBP1	CRM1	5902	7514	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	A role for RanBP1 in the release of CRM1 from the nuclear_pore_complex in a terminal step of nuclear export .
7616957	0	RanBP1	0,6	RCC1	66,70	RanBP1	RCC1	5902	1104	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	RanBP1 , a Ras-like nuclear G protein binding to Ran/TC4 , inhibits RCC1 via Ran/TC4 .
18946085	0	RanBP2	0,6	Borealin	82,90	RanBP2	Borealin	5903	55143	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin .
11353387	0	RanBP2	84,90	Ran-binding_protein_2	61,82	RanBP2	Ran-binding protein 2	19386(Tax:10090)	19386(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization , expression , and localization of murine Ran-binding_protein_2 -LRB- RanBP2 -RRB- gene .
9108047	0	RanBP2	0,6	Ubc9p	23,28	RanBP2	Ubc9p	100127327(Tax:8355)	380450(Tax:8355)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	RanBP2 associates with Ubc9p and a modified form of RanGAP1 .
12220523	0	RanBPM	22,28	HIPK2	0,5	RanBPM	HIPK2	10048	28996	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	HIPK2 associates with RanBPM .
8995296	0	RanGAP	128,134	Ran	97,100	RanGAP	Ran	5905	5901	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Ran-binding_protein_1 -LRB- RanBP1 -RRB- forms a ternary complex with Ran and karyopherin_beta and reduces Ran GTPase-activating protein -LRB- RanGAP -RRB- inhibition by karyopherin_beta .
18706886	0	RanGAP1	22,29	Mel-18	0,6	RanGAP1	Mel-18	5905	7703	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mel-18 interacts with RanGAP1 and inhibits its sumoylation .
16428860	0	RanGAP1	19,26	Ran	59,62	RanGAP1	Ran	5905	5901	Gene	Gene	Phosphorylation|nmod|START_ENTITY stabilizes|nsubj|Phosphorylation stabilizes|nmod|END_ENTITY	Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1 .
8146159	0	RanGAP1	0,7	Ran	55,58	RanGAP1	Ran	5905	5901	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|nmod|END_ENTITY	RanGAP1 induces GTPase activity of nuclear Ras-related Ran .
9456312	0	RanGAP1	81,88	Ran	50,53	RanGAP1	Ran	5905	5901	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	SUMO-1 modification and its role in targeting the Ran GTPase-activating protein , RanGAP1 , to the nuclear pore complex .
11854305	0	RanGAP1	15,22	SUMO-1	0,6	RanGAP1	SUMO-1	5905	7341	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles .
25825446	0	Rankl	52,57	IL-10	0,5	Rankl	IL-10	21943(Tax:10090)	16153(Tax:10090)	Gene	Gene	Responsiveness|nmod|START_ENTITY Responsiveness|compound|END_ENTITY	IL-10 Critically Modulates B Cell Responsiveness in Rankl - / - Mice .
21487009	0	Rankl	6,11	c-Fos	50,55	Rankl	c-Fos	21943(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region .
11278738	0	Rantes	0,6	Jak2	17,21	Rantes	Jak2	6352	3717	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Rantes activates Jak2 and Jak3 to regulate engagement of multiple signaling pathways in T cells .
12502878	0	Rap	94,97	E6TP1	75,80	Rap	E6TP1	4043	26037	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	The high-risk human papillomavirus_type_16 E6 counters the GAP function of E6TP1 toward small Rap G proteins .
10926822	0	Rap	17,20	RGS14	0,5	Rap	RGS14	16976(Tax:10090)	51791(Tax:10090)	Gene	Gene	effector|compound|START_ENTITY effector|nsubj|END_ENTITY	RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao .
17336901	0	Rap	81,84	SIPA1L1	70,77	Rap	SIPA1L1	100002737(Tax:7955)	562521(Tax:7955)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1 , a Rap GTPase activating protein .
24378569	0	Rap-1	60,65	EPAC	54,58	Rap-1	EPAC	5906	10411	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Targeting endothelial junctional adhesion molecule-A / EPAC / Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic_muscles .
18809728	0	Rap1	112,116	Abl	71,74	Rap1	Abl	27342	25	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	The WAVE2 complex regulates T cell receptor signaling to integrins via Abl - and CrkL-C3G-mediated activation of Rap1 .
25963656	0	Rap1	0,4	ArhGAP29	24,32	Rap1	ArhGAP29	27342	9411	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Rap1 spatially controls ArhGAP29 to inhibit Rho signaling during endothelial barrier regulation .
15596148	0	Rap1	18,22	BCR/ABL	0,7	Rap1	BCR/ABL	109905(Tax:10090)	110279(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells .
15870282	0	Rap1	31,35	CTLA-4	109,115	Rap1	CTLA-4	109905(Tax:10090)	12477(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the small GTPase Rap1 and extracellular_signal-regulated_kinases by the costimulatory molecule CTLA-4 .
11278453	0	Rap1	18,22	CalDAG-GEF_I	57,69	Rap1	CalDAG-GEF I	109905(Tax:10090)	19395(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Activation of the Rap1 guanine_nucleotide exchange gene , CalDAG-GEF_I , in BXH-2 murine myeloid_leukemia .
23416045	0	Rap1	15,19	Cdk5	0,4	Rap1	Cdk5	27342	1020	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Cdk5 regulates Rap1 activity .
11175351	0	Rap1	93,97	Crk	4,7	Rap1	Crk	109905(Tax:10090)	12928(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY contributes|nmod|activation contributes|nsubj|signaling signaling|compound|END_ENTITY	The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss_3T3 cells .
8524240	0	Rap1	18,22	Crk	43,46	Rap1	Crk	5906	1398	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|C3G C3G|compound|END_ENTITY	Identification of Rap1 as a target for the Crk SH3 domain-binding guanine_nucleotide-releasing factor C3G .
9268367	0	Rap1	63,67	Crk	89,92	Rap1	Crk	27342	1398	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk , CrkL , and Grb2 .
11375794	0	Rap1	31,35	Epac	25,29	Rap1	Epac	5906	10411	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Mutation analysis of the Epac -- Rap1 signaling pathway in cold thyroid_follicular_adenomas .
12887090	0	Rap1	15,19	Epac	133,137	Rap1	Epac	109905(Tax:10090)	223864(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|parataxis|mediated mediated|nmod|END_ENTITY	CAMP activates Rap1 in differentiating mouse male germ cells : a new signaling pathway mediated by the cAMP-activated exchange factor Epac ?
17068197	0	Rap1	87,91	Epac	111,115	Rap1	Epac	5906	10411	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Cyclic_adenosine_5 ' - monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways .
19546222	0	Rap1	36,40	Epac	0,4	Rap1	Epac	27342	10411	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis .
9853756	0	Rap1	10,14	Epac	0,4	Rap1	Epac	5906	10411	Gene	Gene	factor|amod|START_ENTITY factor|nsubj|END_ENTITY	Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic_AMP .
9311917	0	Rap1	85,89	IL-2	48,52	Rap1	IL-2	5906	3558	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Maintenance of human T cell anergy : blocking of IL-2 gene transcription by activated Rap1 .
17517894	0	Rap1	13,17	IQGAP1	0,6	Rap1	IQGAP1	5906	8826	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	IQGAP1 binds Rap1 and modulates its activity .
16339077	0	Rap1	23,27	MAGI-1	0,6	Rap1	MAGI-1	27342	9223	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular_endothelial_cadherin-mediated cell adhesion .
18796635	0	Rap1	65,69	PKC-theta	0,9	Rap1	PKC-theta	5906	5588	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	PKC-theta selectively controls the adhesion-stimulating molecule Rap1 .
11359771	0	Rap1	51,55	RA-GEF-1	0,8	Rap1	RA-GEF-1	5906	9693	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	RA-GEF-1 , a guanine_nucleotide exchange factor for Rap1 , is activated by translocation induced by association with Rap1 * GTP and enhances Rap1-dependent B-Raf activation .
16757337	0	Rap1	0,4	RIAM	19,23	Rap1	RIAM	54386	54518	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Rap1 regulation of RIAM and cell adhesion .
17403904	0	Rap1	48,52	RIAM	0,4	Rap1	RIAM	5906	54518	Gene	Gene	signaling|nmod|START_ENTITY ADAP/SKAP|acl|signaling links|dobj|ADAP/SKAP links|nsubj|END_ENTITY	RIAM links the ADAP/SKAP -55 signaling module to Rap1 , facilitating T-cell-receptor-mediated integrin activation .
24287201	0	Rap1	17,21	RIAM	38,42	Rap1	RIAM	5906	54518	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism .
24491570	0	Rap1	80,84	Rapgef6	30,37	Rap1	Rapgef6	109905(Tax:10090)	192786(Tax:10090)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Critical function of RA-GEF-2 / Rapgef6 , a guanine_nucleotide exchange factor for Rap1 , in mouse spermatogenesis .
26483383	0	Rap1	115,119	SLAT	0,4	Rap1	SLAT	5906	50619	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	SLAT promotes TCR-mediated , Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1 .
18813851	0	Rap1	86,90	Spa-1	30,35	Rap1	Spa-1	5906	6494	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Bcr/Abl P190 interaction with Spa-1 , a GTPase activating protein for the small GTPase Rap1 .
21636859	0	Rap1	0,4	VEGFR2	14,20	Rap1	VEGFR2	109905(Tax:10090)	16542(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activation activation|nummod|END_ENTITY	Rap1 promotes VEGFR2 activation and angiogenesis by a mechanism involving integrin avb .
24840609	0	Rap1	37,41	Zscan4	0,6	Rap1	Zscan4	54386	201516	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status .
19589776	0	Rap1	64,68	afadin	14,20	Rap1	afadin	109905(Tax:10090)	17356(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by afadin of cyclical activation and inactivation of Rap1 , Rac1 , and RhoA small G proteins at leading edges of moving NIH3T3 cells .
20028760	0	Rap1	0,4	beta-catenin	16,28	Rap1	beta-catenin	5906	1499	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous_cell_carcinoma of the head_and_neck .
11124936	0	Rap1	0,4	erythropoietin	21,35	Rap1	erythropoietin	5906	2056	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1_integrin-mediated hematopoietic cell adhesion .
12892706	0	Rap1	11,15	rap	6,9	Rap1	rap	5906	4043	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|dep|signaling	A bad rap : Rap1 signaling and oncogenesis .
21454517	0	Rap1-GTP-interacting_adaptor_molecule	0,37	RIAM	39,43	Rap1-GTP-interacting adaptor molecule	RIAM	54518	54518	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Rap1-GTP-interacting_adaptor_molecule -LRB- RIAM -RRB- protein controls invasion and growth of melanoma cells .
26599016	0	Rap1A	0,5	ERK	53,56	Rap1A	ERK	5906	5594	Gene	Gene	Differentiation|compound|START_ENTITY Differentiation|nmod|END_ENTITY	Rap1A Regulates Osteoblastic Differentiation via the ERK and p38 Mediated Signaling .
1899909	0	Rap1A	112,117	H-Ras	106,111	Rap1A	H-Ras	109905(Tax:10090)	15461(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|dep|protein	The COOH-terminal domain of the Rap1A -LRB- Krev-1 -RRB- protein is isoprenylated and supports transformation by an H-Ras : Rap1A chimeric protein .
1899909	0	Rap1A	32,37	Krev-1	39,45	Rap1A	Krev-1	109905(Tax:10090)	109905(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The COOH-terminal domain of the Rap1A -LRB- Krev-1 -RRB- protein is isoprenylated and supports transformation by an H-Ras : Rap1A chimeric protein .
18842593	0	Rap1B	49,54	Rheb	0,4	Rap1B	Rheb	5908	6009	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Rheb and mTOR regulate neuronal polarity through Rap1B .
21367844	0	Rap1GAP	42,49	Histone_deacetylase	0,19	Rap1GAP	Histone deacetylase	5909	9734	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	Histone_deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid_tumor cells .
20877310	0	Rap1GAP	0,7	RET	23,26	Rap1GAP	RET	5909	5979	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth .
12370312	0	Rap1_GTPase	61,72	PDZ-GEF	11,18	Rap1 GTPase	PDZ-GEF	38244(Tax:7227)	33881(Tax:7227)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Drosophila PDZ-GEF , a guanine_nucleotide exchange factor for Rap1_GTPase , reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway .
21480213	0	Rap1a	0,5	CalDAG-GEFI	20,31	Rap1a	CalDAG-GEFI	109905(Tax:10090)	19395(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Rap1a activation by CalDAG-GEFI and p38_MAPK is involved in E-selectin-dependent slow leukocyte rolling .
7925441	0	Rap1p	41,46	FAS1	118,122	Rap1p	FAS1	855505(Tax:4932)	853653(Tax:4932)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Importance of general regulatory factors Rap1p , Abf1p and Reb1p for the activation of yeast fatty_acid synthase genes FAS1 and FAS2 .
18195009	0	Rap1p	48,53	TATA-binding_protein	79,99	Rap1p	TATA-binding protein	54386	6908	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The transcriptional repressor activator protein Rap1p is a direct regulator of TATA-binding_protein .
26201295	0	Rap2B	0,5	ERK1/2	101,107	Rap2B	ERK1/2	5912	5595;5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Rap2B promotes proliferation , migration , and invasion of human breast_cancer through calcium-related ERK1/2 signaling pathway .
26201295	0	Rap2B	0,5	ERK1/2	101,107	Rap2B	ERK1/2	5912	5595;5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Rap2B promotes proliferation , migration , and invasion of human breast_cancer through calcium-related ERK1/2 signaling pathway .
15986426	0	Rap2_interacting_protein_9	21,47	RPIP9	14,19	Rap2 interacting protein 9	RPIP9	154661	154661	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of RPIP9 -LRB- Rap2_interacting_protein_9 -RRB- is activated in breast_carcinoma and correlates with a poor prognosis .
25728512	0	Rap2a	0,5	p53	32,35	Rap2a	p53	5911	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion .
23535297	0	Rap2b	0,5	p53	15,18	Rap2b	p53	5912	7157	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	Rap2b , a novel p53 target , regulates p53-mediated pro-survival function .
7687472	0	Rapamycin	0,9	interferon-gamma	33,49	Rapamycin	interferon-gamma	74370(Tax:10090)	15978(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T_cell_lymphoma .
24491570	0	Rapgef6	30,37	Rap1	80,84	Rapgef6	Rap1	192786(Tax:10090)	109905(Tax:10090)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Critical function of RA-GEF-2 / Rapgef6 , a guanine_nucleotide exchange factor for Rap1 , in mouse spermatogenesis .
9136771	0	Rapsyn	0,6	MuSK	23,27	Rapsyn	MuSK	19400(Tax:10090)	18198(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|signaling signaling|compound|END_ENTITY	Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold .
26588989	0	Raptor	19,25	NLK	0,3	Raptor	NLK	57521	51701	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition .
26582740	0	Raptor	44,50	NPRL2	21,26	Raptor	NPRL2	31543(Tax:7227)	32677(Tax:7227)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Amino_acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation .
24516643	0	Raptor	124,130	PDK1	99,103	Raptor	PDK1	57521	5163	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Activated a2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor .
21071439	0	Raptor	21,27	mTOR	67,71	Raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	phosphorylate|dobj|START_ENTITY phosphorylate|xcomp|promote promote|dobj|activation activation|nmod|END_ENTITY	ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 -LRB- mTORC1 -RRB- .
21900751	0	Raptor	0,6	mTOR	41,45	Raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	START_ENTITY|appos|subunit subunit|nmod|complex complex|compound|END_ENTITY	Raptor , a positive regulatory subunit of mTOR complex 1 , is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions -LRB- NORs -RRB- .
22493283	0	Raptor	115,121	mTOR	56,60	Raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY Kinase|dep|phosphorylation regulates|nmod|Kinase regulates|dobj|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	Osmotic stress regulates mammalian_target_of_rapamycin -LRB- mTOR -RRB- complex 1 via c-Jun N-terminal Kinase -LRB- JNK -RRB- - mediated Raptor protein phosphorylation .
24239769	0	Raptor	11,17	mTOR	66,70	Raptor	mTOR	74370(Tax:10090)	21977(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY phosphorylation|nsubj|role phosphorylation|nmod|activation activation|nmod|signaling signaling|compound|END_ENTITY	A role for Raptor phosphorylation in the mechanical activation of mTOR signaling .
26582740	0	Raptor	44,50	mTOR	62,66	Raptor	mTOR	31543(Tax:7227)	21977(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY determines|nsubj|interaction determines|dobj|activation activation|amod|END_ENTITY	Amino_acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation .
9434940	0	Rara	88,92	retinoic_acid_receptor_alpha	58,86	Rara	retinoic acid receptor alpha	19401(Tax:10090)	19401(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A new mutation Rim3 resembling Re -LRB- den -RRB- is mapped close to retinoic_acid_receptor_alpha -LRB- Rara -RRB- gene on mouse chromosome 11 .
11439350	0	Ras-GAP_SH3_domain_binding_protein	0,34	USP10	60,65	Ras-GAP SH3 domain binding protein	USP10	10146	9100	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|END_ENTITY	Ras-GAP_SH3_domain_binding_protein -LRB- G3BP -RRB- is a modulator of USP10 , a novel human ubiquitin specific protease .
16912161	0	Ras-associated_protein-1	0,24	extracellular_signal-regulated_kinase	35,72	Ras-associated protein-1	extracellular signal-regulated kinase	27342	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	Ras-associated_protein-1 regulates extracellular_signal-regulated_kinase activation and migration in melanoma cells : two processes important to melanoma_tumorigenesis and metastasis .
12647816	0	Ras-association_domain_family_1	31,62	RASSF1A	64,71	Ras-association domain family 1	RASSF1A	11186	11186	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic inactivation of the Ras-association_domain_family_1 -LRB- RASSF1A -RRB- gene and its function in human carcinogenesis .
12101233	0	Ras-extracellular_signal-regulated_kinase	100,141	epidermal_growth_factor_receptor	179,211	Ras-extracellular signal-regulated kinase	epidermal growth factor receptor	5594	1956	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	The UV -LRB- Ribotoxic -RRB- stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular_signal-regulated_kinase signaling cascade from the activated epidermal_growth_factor_receptor .
22358380	0	Ras-related_C3_botulinum_toxin_substrate_1	14,56	RAC1	58,62	Ras-related C3 botulinum toxin substrate 1	RAC1	5879	5879	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Ras-related_C3_botulinum_toxin_substrate_1 -LRB- RAC1 -RRB- in human cholesteatoma .
24648519	0	Ras-related_associated_with_diabetes	49,85	RRAD	43,47	Ras-related associated with diabetes	RRAD	6236	6236	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ras-induced epigenetic inactivation of the RRAD -LRB- Ras-related_associated_with_diabetes -RRB- gene promotes glucose uptake in a human ovarian_cancer model .
21073870	0	Ras2	23,27	Cdc25p	86,92	Ras2	Cdc25p	855625(Tax:4932)	851019(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Feedback regulation of Ras2 guanine_nucleotide exchange factor -LRB- Ras2-GEF -RRB- activity of Cdc25p by Cdc25p phosphorylation in the yeast Saccharomyces_cerevisiae .
22205990	0	RasGAP	22,28	G3BP1	11,16	RasGAP	G3BP1	5921	10146	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Revisiting G3BP1 as a RasGAP binding protein : sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1 .
23082153	0	RasGAP	4,10	LIMK2	25,30	RasGAP	LIMK2	5921	3985	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways .
23082153	0	RasGAP	4,10	Nf1	0,3	RasGAP	Nf1	5921	4763	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Nf1 RasGAP inhibition of LIMK2 mediates a new cross-talk between Ras and Rho pathways .
24029233	0	RasGAP	4,10	RASAL2	17,23	RasGAP	RASAL2	5921	9462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The RasGAP gene , RASAL2 , is a tumor and metastasis suppressor .
25652366	0	RasGAP	30,36	RASAL3	0,6	RasGAP	RASAL3	218397(Tax:10090)	320484(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	RASAL3 , a novel hematopoietic RasGAP protein , regulates the number and functions of NKT cells .
23251034	0	RasGAP	23,29	Rasal	76,81	RasGAP	Rasal	5921	8437	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Ras GTPase activating -LRB- RasGAP -RRB- activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes .
10022880	0	RasGAP	52,58	p120	73,77	RasGAP	p120	32569(Tax:7227)	36499(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|protein protein|amod|END_ENTITY	Control of growth and differentiation by Drosophila RasGAP , a homolog of p120 Ras-GTPase-activating protein .
17188236	0	RasGAP	47,53	p120	42,46	RasGAP	p120	5921	1500	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	High resolution crystal structures of the p120 RasGAP SH3 domain .
20107120	0	RasGRF1	110,117	NR2A	45,49	RasGRF1	NR2A	5923	2903	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1 .
17135267	0	RasGRF1	58,65	SCLIP	0,5	RasGRF1	SCLIP	192213(Tax:10116)	29246(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SCLIP , a microtubule-destabilizing factor , interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth .
11279364	0	RasGRP	46,52	ras_guanyl_releasing_protein	16,44	RasGRP	ras guanyl releasing protein	29434(Tax:10116)	29434(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Distribution of ras_guanyl_releasing_protein -LRB- RasGRP -RRB- mRNA in the adult rat central nervous system .
20007535	0	RasGRP1	0,7	CD8	69,72	RasGRP1	CD8	10125	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|compound|END_ENTITY	RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells .
20203268	0	RasGRP1	109,116	Gfi1	25,29	RasGRP1	Gfi1	19419(Tax:10090)	14581(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1 .
25682201	0	RasGRP3	0,7	Arp3	69,73	RasGRP3	Arp3	25780	10096	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	RasGRP3 regulates the migration of glioma cells via interaction with Arp3 .
15143162	0	RasGRP3	128,135	c-Src	103,108	RasGRP3	c-Src	25780	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Rap2B-dependent stimulation of phospholipase_C-epsilon by epidermal_growth_factor_receptor mediated by c-Src phosphorylation of RasGRP3 .
14707121	0	Ras_GTPase-activating_protein	0,29	Akt	39,42	Ras GTPase-activating protein	Akt	5921	207	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Ras_GTPase-activating_protein binds to Akt and is required for its activation .
18182852	0	Ras_association_domain_family_1A	24,56	RASSF1A	58,65	Ras association domain family 1A	RASSF1A	11186	11186	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hypermethylation of the Ras_association_domain_family_1A -LRB- RASSF1A -RRB- gene in gallbladder_cancer .
23382905	0	Ras_homologous_C	18,34	RhoC	36,40	Ras homologous C	RhoC	11853(Tax:10090)	11853(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of Ras_homologous_C -LRB- RhoC -RRB- induces malignant_transformation_of_hepatocytes in vitro and in nude mouse xenografts .
19802870	0	Ras_responsive_element_binding_protein-1	0,40	hZIP1	65,70	Ras responsive element binding protein-1	hZIP1	6239	27173	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Ras_responsive_element_binding_protein-1 -LRB- RREB-1 -RRB- down-regulates hZIP1 expression in prostate_cancer cells .
25647720	0	Ras_suppressor-1	0,16	PINCH-1	73,80	Ras suppressor-1	PINCH-1	6251	3987	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Ras_suppressor-1 promotes apoptosis in breast_cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis -LRB- PUMA -RRB- ; verification from metastatic breast_cancer human samples .
15596544	0	Ras_suppressor_1	92,108	PINCH	22,27	Ras suppressor 1	PINCH	34774(Tax:7227)	40999(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras_suppressor_1 .
23251034	0	Rasal	76,81	RasGAP	23,29	Rasal	RasGAP	8437	5921	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Ras GTPase activating -LRB- RasGAP -RRB- activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes .
21247419	0	Rasd1	0,5	Ear2	21,25	Rasd1	Ear2	19416(Tax:10090)	13587(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rasd1 interacts with Ear2 -LRB- Nr2f6 -RRB- to regulate renin transcription .
23798437	0	Rasip1	0,6	ArhGAP29	79,87	Rasip1	ArhGAP29	54922	9411	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29 .
19523901	0	Raver1	0,6	vinculin	25,33	Raver1	vinculin	125950	7414	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions .
18385377	0	Rax	92,95	Sox2	76,80	Rax	Sox2	379187(Tax:8355)	398000(Tax:8355)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Molecular links among the causative genes for ocular_malformation : Otx2 and Sox2 coregulate Rax expression .
21158042	0	Rb1	12,15	Bax	52,55	Rb1	Bax	5925	581	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of Rb1 and Rg1 on the expression of Bcl-2 , Bax in apoptosis of HK-2 cells induced by the serum of kidney_ischemia / reperfusion -RSB- .
21158042	0	Rb1	12,15	Bcl-2	45,50	Rb1	Bcl-2	5925	596	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of Rb1 and Rg1 on the expression of Bcl-2 , Bax in apoptosis of HK-2 cells induced by the serum of kidney_ischemia / reperfusion -RSB- .
25520758	0	Rb1	27,30	MicroRNA-21	0,11	Rb1	MicroRNA-21	5925	406991	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma .
15716956	0	Rb1	21,24	Mitf	0,4	Rb1	Mitf	5925	4286	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression .
25520758	0	Rb1	27,30	PDCD4	55,60	Rb1	PDCD4	5925	27250	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma .
24019952	0	Rb1	61,64	PPP1R26P1	6,15	Rb1	PPP1R26P1	19645(Tax:10090)	100418740	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Human PPP1R26P1 functions as cis-repressive element in mouse Rb1 .
20713524	0	Rb1	25,28	miR-335	0,7	Rb1	miR-335	5925	442904	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	miR-335 directly targets Rb1 -LRB- pRb/p105 -RRB- in a proximal connection to p53-dependent stress response .
22886530	0	Rb1	58,61	miR-335	0,7	Rb1	miR-335	5925	442904	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas .
17900658	0	Rb1	36,39	p15	55,58	Rb1	p15	5925	1030	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular_lymphoma .
7478595	0	Rb2	45,48	E2F-1	14,19	Rb2	E2F-1	5934	1869	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of E2F-1 gene expression by p130 -LRB- Rb2 -RRB- and D-type cyclin kinase activity .
21047798	0	RbAp48	90,96	FOG-1	98,103	RbAp48	FOG-1	5928	161882	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Insights into association of the NuRD complex with FOG-1 from the crystal structure of an RbAp48 FOG-1 complex .
11470869	0	RbAp48	38,44	HDAC3	24,29	RbAp48	HDAC3	5928	8841	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein .
22231628	0	RbBP5	70,75	Ash2L	38,43	RbBP5	Ash2L	5929	9070	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30 .
26208635	0	Rbf1	39,43	retinoblastoma	15,29	Rbf1	retinoblastoma	31027(Tax:7227)	31027(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The Drosophila retinoblastoma protein , Rbf1 , induces a debcl and drp1-dependent mitochondrial apoptosis .
26208635	0	Rbf1	39,43	retinoblastoma	15,29	Rbf1	retinoblastoma	31027(Tax:7227)	31027(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The Drosophila retinoblastoma protein , Rbf1 , induces a debcl and drp1-dependent mitochondrial apoptosis .
24356969	0	Rbm24	0,5	p21	61,64	Rbm24	p21	221662	644914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Rbm24 , an RNA-binding protein and a target of p53 , regulates p21 expression via mRNA stability .
12824175	0	Rbm3	90,94	RNA-binding_motif_protein_3	61,88	Rbm3	RNA-binding motif protein 3	5935	5935	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	The internal ribosome entry site -LRB- IRES -RRB- contained within the RNA-binding_motif_protein_3 -LRB- Rbm3 -RRB- mRNA is composed of functionally distinct elements .
23649762	0	Rbm47	20,25	Nanog	35,40	Rbm47	Nanog	245945(Tax:10090)	71950(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells .
22372950	0	Rbms3	0,5	Ptf1a	58,63	Rbms3	Ptf1a	207181(Tax:10090)	19213(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Rbms3 , an RNA-binding protein , mediates the expression of Ptf1a by binding to its 3 ` UTR during mouse pancreas development .
21998293	0	Rbp1p	39,44	Dhh1p	17,22	Rbp1p	Dhh1p	5947	851394(Tax:4932)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The RNA helicase Dhh1p cooperates with Rbp1p to promote porin mRNA decay via its non-conserved C-terminal domain .
24631193	0	Rbpj	93,97	Hnf6	61,65	Rbpj	Hnf6	19664(Tax:10090)	15379(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj .
22405651	0	Rbx1	52,56	Glomulin	37,45	Rbx1	Glomulin	9978	11146	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The glomuvenous_malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7 .
26540345	0	Rbx1	36,40	MAGE-C2	22,29	Rbx1	MAGE-C2	9978	51438	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. UNASSIGNED : Cancer-testis antigen MAGE-C2 is normally expressed in testis but aberrantly expressed in various kinds of tumors .
10579999	0	Rbx1	4,8	SCF	20,23	Rbx1	SCF	9978	4254	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 .
26296316	0	Rck1	45,49	Yap2	14,18	Rck1	Yap2	852719(Tax:4932)	852033(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of Yap2 activity by MAPKAP kinase Rck1 affects yeast tolerance to cadmium .
11565748	0	Rcl1p	54,59	Bms1p	0,5	Rcl1p	Bms1p	854152(Tax:4932)	855884(Tax:4932)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Bms1p , a G-domain-containing protein , associates with Rcl1p and is required for 18S rRNA biogenesis in yeast .
12807768	0	Rcy1p	36,41	Gyp2p	76,81	Rcy1p	Gyp2p	853226(Tax:4932)	852992(Tax:4932)	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	Opposite roles of the F-box protein Rcy1p and the GTPase-activating protein Gyp2p during recycling of internalized proteins in yeast .
17249577	1	Rd1	90,93	Bmi1	57,61	Rd1	Bmi1	18587(Tax:10090)	12151(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Bmi1 loss and neuroprotection in Rd1 mice .
17849458	0	Rdh10	51,56	retinol_dehydrogenase_10	25,49	Rdh10	retinol dehydrogenase 10	98711(Tax:10090)	98711(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the murine retinol_dehydrogenase_10 -LRB- Rdh10 -RRB- gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation .
15063128	0	Rec	58,61	HML-2	35,40	Rec	HML-2	58163	10462	Gene	Gene	capacity|compound|START_ENTITY retrovirus|nmod|capacity retrovirus|dobj|proviruses proviruses|appos|END_ENTITY	Human endogenous retrovirus HERV-K -LRB- HML-2 -RRB- proviruses with Rec protein coding capacity and transcriptional activity .
16395745	0	Rec	42,45	HML-2	35,40	Rec	HML-2	58163	10462	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human endogenous retrovirus HERV-K -LRB- HML-2 -RRB- Rec expression and transcriptional activities in normal and rheumatoid_arthritis synovia .
10231368	0	RecA	122,126	RecA	152,156	RecA	RecA	5888	5888	Gene	Gene	dissociation|compound|START_ENTITY dissociation|nmod|END_ENTITY	Difference between active and inactive nucleotide cofactors in the effect on the DNA binding and the helical structure of RecA filament dissociation of RecA -- DNA complex by inactive nucleotides .
10231368	0	RecA	152,156	RecA	122,126	RecA	RecA	5888	5888	Gene	Gene	dissociation|nmod|START_ENTITY dissociation|compound|END_ENTITY	Difference between active and inactive nucleotide cofactors in the effect on the DNA binding and the helical structure of RecA filament dissociation of RecA -- DNA complex by inactive nucleotides .
24108125	0	RecQ-mediated_genome_instability_protein_2	64,106	MPS1	21,25	RecQ-mediated genome instability protein 2	MPS1	116028	7272	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Monopolar_spindle_1 -LRB- MPS1 -RRB- protein-dependent phosphorylation of RecQ-mediated_genome_instability_protein_2 -LRB- RMI2 -RRB- at serine 112 is essential for BLM-Topo III a-RMI1-RMI2 -LRB- BTR -RRB- protein complex function upon spindle assembly checkpoint -LRB- SAC -RRB- activation during mitosis .
25602958	0	RecQL4	0,6	Mcm10	42,47	RecQL4	Mcm10	9401	55388	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|association association|nmod|END_ENTITY	RecQL4 is required for the association of Mcm10 and Ctf4 with replication origins in human cells .
26013822	0	Receptor-Associated_Protein	128,155	RAP	157,160	Receptor-Associated Protein	RAP	4043	4043	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Generation of a potent Low_Density_Lipoprotein_Receptor-related_Protein_1 -LRB- LRP1 -RRB- antagonist by engineering a stable form of the Receptor-Associated_Protein -LRB- RAP -RRB- D3 domain .
8910522	0	Receptor-associated_protein	0,27	low_density_lipoprotein_receptor	47,79	Receptor-associated protein	low density lipoprotein receptor	4043	3949	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	Receptor-associated_protein and members of the low_density_lipoprotein_receptor family share a common epitope .
25702149	0	Receptor-associated_protein	0,27	t-PA	37,41	Receptor-associated protein	t-PA	116565(Tax:10116)	25692(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Receptor-associated_protein promotes t-PA expression , reduces PAI-1 expression and improves neurorecovery after acute ischemic_stroke .
12554755	0	Receptor-interacting_protein_140	0,32	c-Jun	39,44	Receptor-interacting protein 140	c-Jun	8204	3725	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Receptor-interacting_protein_140 binds c-Jun and inhibits estradiol-induced activator_protein-1 activity by reversing glucocorticoid_receptor-interacting_protein_1 effect .
25678116	0	Receptor_Activator_of_NF-kB_Ligand	60,94	RANKL	96,101	Receptor Activator of NF-kB Ligand	RANKL	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Biotechnological approach for systemic delivery of membrane Receptor_Activator_of_NF-kB_Ligand -LRB- RANKL -RRB- active domain into the circulation .
20431232	0	Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand	25,75	RANKL	77,82	Receptor Activator of Nuclear Factor-kappaB Ligand	RANKL	8600	8600	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The relationship between Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand -LRB- RANKL -RRB- gene polymorphism and aortic_calcification in Korean women .
24524041	0	Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand	68,118	RANKL	120,125	Receptor Activator of Nuclear Factor-kappaB Ligand	RANKL	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	a-Tocopheryl_Succinate Inhibits Osteoclast Formation by Suppressing Receptor_Activator_of_Nuclear_Factor-kappaB_Ligand -LRB- RANKL -RRB- Expression and Bone Resorption .
26561998	0	Receptor_Activator_of_Nuclear_Factor-kb_Ligand	56,102	Osteoprotegerin	103,118	Receptor Activator of Nuclear Factor-kb Ligand	Osteoprotegerin	8600	4982	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|System System|compound|END_ENTITY	The Effects of Initial Periodontal Therapy on the Serum Receptor_Activator_of_Nuclear_Factor-kb_Ligand / Osteoprotegerin System in Patients With Type_2_Diabetes_Mellitus and Periodontitis .
25492490	0	Receptor_Activator_of_Nuclear_Factor_Kappa_B_Ligand	65,116	Sphingosine-1-Phosphate_Receptor_1	25,59	Receptor Activator of Nuclear Factor Kappa B Ligand	Sphingosine-1-Phosphate Receptor 1	117516(Tax:10116)	29733(Tax:10116)	Gene	Gene	T|compound|START_ENTITY END_ENTITY|nmod|T	Different Correlation of Sphingosine-1-Phosphate_Receptor_1 with Receptor_Activator_of_Nuclear_Factor_Kappa_B_Ligand and Regulatory T Cells in Rat Periapical Lesions .
26423127	0	Receptor_Activity-Modifying_Protein_3	15,52	RAMP3	54,59	Receptor Activity-Modifying Protein 3	RAMP3	56820(Tax:10116)	56820(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Receptor_Activity-Modifying_Protein_3 -LRB- RAMP3 -RRB- in the Vascular Actions of Adrenomedullin in Rat Mesenteric Artery Smooth Muscle Cells .
26073592	0	Receptor_Tyrosine_Kinase	12,36	EPHB4	6,11	Receptor Tyrosine Kinase	EPHB4	5979	2050	Gene	Gene	Mutations|compound|START_ENTITY Mutations|compound|END_ENTITY	Novel EPHB4 Receptor_Tyrosine_Kinase Mutations and Kinomic Pathway Analysis in Lung_Cancer .
25319891	0	Receptor_Tyrosine_Kinase	46,70	RTK	72,75	Receptor Tyrosine Kinase	RTK	5979	5979	Gene	Gene	Activation|compound|START_ENTITY Activation|appos|END_ENTITY	Quantification of the Effects of Mutations on Receptor_Tyrosine_Kinase -LRB- RTK -RRB- Activation in Mammalian Cells .
21779479	0	Receptor_Tyrosine_Kinase	45,69	c-Jun_N-terminal_Kinase_2	0,25	Receptor Tyrosine Kinase	c-Jun N-terminal Kinase 2	22174(Tax:10090)	26420(Tax:10090)	Gene	Gene	Pathways|compound|START_ENTITY Pathways|amod|END_ENTITY	c-Jun_N-terminal_Kinase_2 Regulates Multiple Receptor_Tyrosine_Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis .
21559440	0	Receptor_activator_of_NF-kB	0,27	RANK	29,33	Receptor activator of NF-kB	RANK	8792	8792	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Receptor_activator_of_NF-kB -LRB- RANK -RRB- expression in primary_tumors associates with bone metastasis occurrence in breast_cancer patients .
18645583	0	Receptor_activator_of_NF-kappaB_Ligand	0,38	RANKL	40,45	Receptor activator of NF-kappaB Ligand	RANKL	8600	8600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Receptor_activator_of_NF-kappaB_Ligand -LRB- RANKL -RRB- expression is associated with epithelial to mesenchymal transition in human prostate_cancer cells .
12952963	0	Receptor_activator_of_NF-kappaB_ligand	0,38	Jak2	53,57	Receptor activator of NF-kappaB ligand	Jak2	21943(Tax:10090)	16452(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Receptor_activator_of_NF-kappaB_ligand induction via Jak2 and Stat5a in mammary epithelial cells .
17306833	0	Receptor_activator_of_NF-kappaB_ligand	0,38	carbonic_anhydrase_II	65,86	Receptor activator of NF-kappaB ligand	carbonic anhydrase II	21943(Tax:10090)	12349(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Receptor_activator_of_NF-kappaB_ligand induces the expression of carbonic_anhydrase_II , cathepsin_K , and matrix_metalloproteinase-9 in osteoclast precursor RAW264 .7 cells .
17195907	0	Receptor_activator_of_nuclear_factor-kappaB_ligand	0,50	RANKL	52,57	Receptor activator of nuclear factor-kappaB ligand	RANKL	8600	8600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- expression in hepatocellular_carcinoma with bone metastasis .
20476881	0	Receptor_activator_of_nuclear_factor-kappa_B_ligand	0,51	osteoprotegerin	52,67	Receptor activator of nuclear factor-kappa B ligand	osteoprotegerin	8600	4982	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Receptor_activator_of_nuclear_factor-kappa_B_ligand / osteoprotegerin ratio in sites of chronic_periodontitis of subjects with poorly and well-controlled type 2 diabetes .
14578201	0	Receptor_activator_of_nuclear_factor_kappaB_ligand	0,50	osteoprotegerin	59,74	Receptor activator of nuclear factor kappaB ligand	osteoprotegerin	8600	4982	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- ratio is increased in severe osteolysis .
21189445	0	Receptor_activator_of_nuclear_factor_kappa_B_ligand	0,51	RANKL	53,58	Receptor activator of nuclear factor kappa B ligand	RANKL	8600	8600	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Receptor_activator_of_nuclear_factor_kappa_B_ligand -LRB- RANKL -RRB- levels in peri-implant crevicular fluid .
19674157	0	Receptor_for_activated_C-kinase_1	0,33	ABCB4	86,91	Receptor for activated C-kinase 1	ABCB4	10399	5244	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Receptor_for_activated_C-kinase_1 regulates the cellular localization and function of ABCB4 .
19010305	0	Receptor_for_activated_C-kinase_1	0,33	adiponectin_receptor_1	62,84	Receptor for activated C-kinase 1	adiponectin receptor 1	10399	51094	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Receptor_for_activated_C-kinase_1 , a novel binding partner of adiponectin_receptor_1 .
23545311	0	Receptor_for_advanced_glycation_end-product	0,43	RAGE	45,49	Receptor for advanced glycation end-product	RAGE	177	177	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Receptor_for_advanced_glycation_end-product -LRB- RAGE -RRB- gene polymorphism 2245G/A is associated with pro-inflammatory , oxidative-glycation markers and sRAGE in diabetic_retinopathy .
20435311	0	Receptor_for_advanced_glycation_end-products	0,44	RAGE	46,50	Receptor for advanced glycation end-products	RAGE	11596(Tax:10090)	11596(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Receptor_for_advanced_glycation_end-products -LRB- RAGE -RRB- regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse .
25731190	0	Receptor_for_hyaluronic_acid-mediated_motility	0,46	RHAMM	48,53	Receptor for hyaluronic acid-mediated motility	RHAMM	3161	3161	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Receptor_for_hyaluronic_acid-mediated_motility -LRB- RHAMM , CD168 -RRB- expression is prognostically important in both nodal negative and nodal positive large cell lung_cancer .
17456798	0	Receptor_interacting_protein_140	0,32	uncoupling_protein_1	57,77	Receptor interacting protein 140	uncoupling protein 1	8204	7350	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Receptor_interacting_protein_140 regulates expression of uncoupling_protein_1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha .
16934227	0	Receptor_tyrosine_kinase	0,24	RTK	26,29	Receptor tyrosine kinase	RTK	5979	5979	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Receptor_tyrosine_kinase -LRB- RTK -RRB- inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian_cancer cell lines when used in combination with cytotoxic agents .
23893409	0	Receptor_tyrosine_kinase-like_orphan_receptor_2	0,47	Ror2	49,53	Receptor tyrosine kinase-like orphan receptor 2	Ror2	4920	4920	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Receptor_tyrosine_kinase-like_orphan_receptor_2 -LRB- Ror2 -RRB- expression creates a poised state of Wnt signaling in renal_cancer .
8445948	0	Recombination_activating_gene-1	0,31	RAG-1	33,38	Recombination activating gene-1	RAG-1	5896	5896	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Recombination_activating_gene-1 -LRB- RAG-1 -RRB- expression in all differentiation stages of B-lineage precursor acute_lymphoblastic_leukemia .
23110142	0	Recombination_activating_gene-2	0,31	interferon-a	55,67	Recombination activating gene-2	interferon-a	19374(Tax:10090)	111654(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Recombination_activating_gene-2 regulates CpG-mediated interferon-a production in mouse bone marrow-derived plasmacytoid dendritic cells .
12447165	0	Recoverin	11,20	RCV1	22,26	Recoverin	RCV1	489500(Tax:9615)	489500(Tax:9615)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The canine Recoverin -LRB- RCV1 -RRB- gene : a candidate gene for generalized progressive retinal_atrophy .
19439225	0	Redd1	132,137	mammalian_target_of_rapamycin	98,127	Redd1	mammalian target of rapamycin	54541	2475	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Activating_transcription_factor_4 and CCAAT/enhancer-binding _ protein-beta negatively regulate the mammalian_target_of_rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress .
20631885	0	Redox_Factor-1	0,14	Cyclooxygenase-2	24,40	Redox Factor-1	Cyclooxygenase-2	328	5743	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Redox_Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells .
11834746	0	Redox_effector_factor-1	0,23	thyroid_transcription_factor_1	50,80	Redox effector factor-1	thyroid transcription factor 1	328	7080	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Redox_effector_factor-1 regulates the activity of thyroid_transcription_factor_1 by controlling the redox state of the N transcriptional activation domain .
18851946	0	Ree1	6,10	ENO1	39,43	Ree1	ENO1	853238(Tax:4932)	853169(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Novel Ree1 regulates the expression of ENO1 via the Snf1 complex pathway in Saccharomyces_cerevisiae .
23506116	0	Reelin	65,71	CIN85	54,59	Reelin	CIN85	5649	30011	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors , ApoER2 and VLDLR , in neurons .
12882964	0	Reelin	85,91	Dab1	65,69	Reelin	Dab1	5649	1600	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Phosphatidylinositol_3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination .
15249135	0	Reelin	33,39	Dab1	25,29	Reelin	Dab1	5649	1600	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper_layer_cortical_plate_neurons .
12670700	0	Reelin	20,26	Disabled-1	84,94	Reelin	Disabled-1	19699(Tax:10090)	13131(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY mediates|nsubj|Binding mediates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1 .
16481437	0	Reelin	25,31	Disabled-1	73,83	Reelin	Disabled-1	19699(Tax:10090)	13131(Tax:10090)	Gene	Gene	dissection|nmod|START_ENTITY dissection|nmod|adaptor adaptor|compound|END_ENTITY	Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein_E_receptor_2 : distinct roles in development and synaptic plasticity .
19796633	0	Reelin	95,101	Disabled-1	61,71	Reelin	Disabled-1	19699(Tax:10090)	13131(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY transmission|nmod|signaling END_ENTITY|nmod|transmission	Relative importance of the tyrosine phosphorylation sites of Disabled-1 to the transmission of Reelin signaling .
22394407	0	Reelin	0,6	Disabled-1	95,105	Reelin	Disabled-1	5649	1600	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|signaling signaling|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation .
9716537	0	Reelin	30,36	Disabled-1	0,10	Reelin	Disabled-1	5649	13131(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain .
16514107	0	Reelin	0,6	Erk1/2	109,115	Reelin	Erk1/2	24718(Tax:10116)	50689;116590	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|amod|END_ENTITY	Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation .
24876378	0	Reelin	0,6	Erk1/2	15,21	Reelin	Erk1/2	5649	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway .
18593473	0	Reelin	0,6	Notch-1	90,97	Reelin	Notch-1	5649	4851	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1 .
12882964	0	Reelin	85,91	Phosphatidylinositol_3-kinase	0,29	Reelin	Phosphatidylinositol 3-kinase	5649	5295	Gene	Gene	signaling|compound|START_ENTITY Dab1|nmod|signaling Dab1|nsubj|interacts interacts|amod|END_ENTITY	Phosphatidylinositol_3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination .
20727978	0	Reelin	4,10	RELN	12,16	Reelin	RELN	5649	5649	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The Reelin -LRB- RELN -RRB- gene is associated with executive function in healthy individuals .
23236151	0	Reelin	0,6	ataxin-7	45,53	Reelin	ataxin-7	5649	6314	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar_ataxia_type_7 -LRB- SCA7 -RRB- astrocytes .
10571241	0	Reelin	18,24	disabled-1	98,108	Reelin	disabled-1	19699(Tax:10090)	13131(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY induces|nsubj|binding induces|dobj|phosphorylation phosphorylation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Direct binding of Reelin to VLDL_receptor and ApoE_receptor_2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation .
12446734	0	Reelin	70,76	disabled-1	18,28	Reelin	disabled-1	5649	1600	Gene	Gene	pathway|compound|START_ENTITY adaptor|nmod|pathway END_ENTITY|appos|adaptor	The gene encoding disabled-1 -LRB- DAB1 -RRB- , the intracellular adaptor of the Reelin pathway , reveals unusual complexity in human and mouse .
19074029	0	Reelin	82,88	disabled-1	64,74	Reelin	disabled-1	19699(Tax:10090)	13131(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway .
17698586	0	Reelin	0,6	phosphatidylinositol_3-kinase	23,52	Reelin	phosphatidylinositol 3-kinase	5649	5293	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Reelin signals through phosphatidylinositol_3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth .
12552119	0	Ref-1	31,36	AP-1	37,41	Ref-1	AP-1	328	3726	Gene	Gene	identification|nmod|START_ENTITY identification|dep|END_ENTITY	Chemogenomic identification of Ref-1 / AP-1 as a therapeutic target for asthma .
19524065	0	Ref-1	17,22	HIF-1	0,5	Ref-1	HIF-1	328	3091	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	HIF-1 attenuates Ref-1 expression in endothelial cells : reversal by siRNA and inhibition of geranylgeranylation .
9813166	0	Ref-1	0,5	pax-8	15,20	Ref-1	pax-8	328	7849	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|activity activity|amod|END_ENTITY	Ref-1 controls pax-8 DNA-binding activity .
8736558	0	Ref-1	75,80	thioredoxin	32,43	Ref-1	thioredoxin	7980	7295	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal .
21709252	0	RefilinB	0,8	filamin_A	27,36	RefilinB	filamin A	359845	2316	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	RefilinB -LRB- FAM101B -RRB- targets filamin_A to organize perinuclear actin networks and regulates nuclear shape .
15777617	0	Reg	28,31	PAP_IB	0,6	Reg	PAP IB	5967	130120	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	PAP_IB , a new member of the Reg gene family : cloning , expression , structural properties , and evolution by gene duplication .
23133598	0	Reg_IV	0,6	CDX2	63,67	Reg IV	CDX2	83998	1045	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Reg_IV is a direct target of intestinal transcriptional factor CDX2 in gastric_cancer .
16323007	0	Reg_IV	25,31	RELP	19,23	Reg IV	RELP	83998	83998	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High expression of RELP -LRB- Reg_IV -RRB- in neoplastic goblet cells of appendiceal mucinous_cystadenoma and pseudomyxoma_peritonei .
16401477	0	Reg_IV	0,6	epidermal_growth_factor_receptor	21,53	Reg IV	epidermal growth factor receptor	83998	1956	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Reg_IV activates the epidermal_growth_factor_receptor / Akt/AP -1 signaling pathway in colon_adenocarcinomas .
19670418	0	Reg_IV	56,62	olfactomedin_4	6,20	Reg IV	olfactomedin 4	83998	10562	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Serum olfactomedin_4 -LRB- GW112 , hGC-1 -RRB- in combination with Reg_IV is a highly sensitive biomarker for gastric_cancer patients .
11241271	0	Regeneration_and_tolerance_factor	0,33	IL-10	64,69	Regeneration and tolerance factor	IL-10	23545	3586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Regeneration_and_tolerance_factor of the human placenta induces IL-10 production .
18219274	0	Reggie-1	0,8	flotillin-2	9,20	Reggie-1	flotillin-2	32425(Tax:7227)	32425(Tax:7227)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Reggie-1 / flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila .
22130514	0	Regulator_of_G-protein_signaling_5	0,34	RGS5	36,40	Regulator of G-protein signaling 5	RGS5	8490	8490	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulator_of_G-protein_signaling_5 -LRB- RGS5 -RRB- protein : a novel marker of cancer vasculature elicited and sustained by the tumor 's proangiogenic microenvironment .
25792749	0	Regulator_of_G_Protein_Signaling_7	53,87	GPR158	16,22	Regulator of G Protein Signaling 7	GPR158	24012(Tax:10090)	241263(Tax:10090)	Gene	Gene	Modulator|nmod|START_ENTITY Modulator|nsubj|END_ENTITY	Orphan Receptor GPR158 is an Allosteric Modulator of Regulator_of_G_Protein_Signaling_7 -LRB- RGS7 -RRB- Catalytic Activity with Essential Role in Dictating its Expression and Localization in the Brain .
25792749	0	Regulator_of_G_Protein_Signaling_7	53,87	GPR158	16,22	Regulator of G Protein Signaling 7	GPR158	24012(Tax:10090)	241263(Tax:10090)	Gene	Gene	Modulator|nmod|START_ENTITY Modulator|nsubj|END_ENTITY	Orphan Receptor GPR158 is an Allosteric Modulator of Regulator_of_G_Protein_Signaling_7 -LRB- RGS7 -RRB- Catalytic Activity with Essential Role in Dictating its Expression and Localization in the Brain .
21859827	0	Regulator_of_G_protein_signaling_6	0,34	ATM	64,67	Regulator of G protein signaling 6	ATM	9628	472	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Regulator_of_G_protein_signaling_6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species-dependent mechanism .
22179605	0	Regulator_of_G_protein_signaling_6	0,34	RGS6	36,40	Regulator of G protein signaling 6	RGS6	9628	9628	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulator_of_G_protein_signaling_6 -LRB- RGS6 -RRB- protein ensures coordination of motor movement by modulating GABAB receptor signaling .
21616123	0	Regulator_of_G_protein_signaling_9-2	0,36	RGS9-2	38,44	Regulator of G protein signaling 9-2	RGS9-2	19739(Tax:10090)	19739(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Regulator_of_G_protein_signaling_9-2 -LRB- RGS9-2 -RRB- mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells .
19441079	0	Regulator_of_differentiation_1	0,30	C-terminal_peptide	63,81	Regulator of differentiation 1	C-terminal peptide	9991	79718	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Regulator_of_differentiation_1 -LRB- ROD1 -RRB- binds to the amphipathic C-terminal_peptide of thrombospondin-4 and is involved in its mitogenic activity .
26811338	0	Regulators_of_G_protein_Signaling	90,123	RGS	125,128	Regulators of G protein Signaling	RGS	5308	5308	Gene	Gene	Proteins|compound|START_ENTITY Proteins|appos|END_ENTITY	Association with the Plasma Membrane is Sufficient for Potentiating Catalytic Activity of Regulators_of_G_protein_Signaling -LRB- RGS -RRB- Proteins of the R7 subfamily .
9813023	0	Regulators_of_G_protein_signaling	0,33	RGS	35,38	Regulators of G protein signaling	RGS	5308	5308	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Regulators_of_G_protein_signaling -LRB- RGS -RRB- proteins constitutively activate Gbeta gamma-gated potassium channels .
8683159	0	Rel	38,41	CD40	70,74	Rel	CD40	19696(Tax:10090)	21939(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Maintenance of nuclear_factor-kappa_B / Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins .
10079054	0	Rel	110,113	NF-kappa_B	99,109	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Acetylaminofluorene inhibits nitric_oxide production in LPS-stimulated RAW 264.7 cells by blocking NF-kappa_B / Rel activation .
10508271	0	Rel	82,85	NF-kappa_B	71,81	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY differences|parataxis|signaling differences|nmod|dependence dependence|nmod|END_ENTITY	Lineage-specific differences among CD8 + T cells in their dependence of NF-kappa_B / Rel signaling .
10744656	0	Rel	207,210	NF-kappa_B	196,206	Rel	NF-kappa B	5966	4790	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Stimulation of Fc gamma R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I_kappa_B-alpha degradation and formation of p50/p65 NF-kappa_B / Rel complexes .
10918492	0	Rel	105,108	NF-kappa_B	94,104	Rel	NF-kappa B	5966	4790	Gene	Gene	Enhancement|dep|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of cytosine_arabinoside-induced apoptosis in human myeloblastic_leukemia cells by NF-kappa_B / Rel - specific decoy oligodeoxynucleotides .
10918492	3	Rel	502,505	NF-kappa_B	491,501	Rel	NF-kappa B	5966	4790	Gene	Gene	sequence|dep|START_ENTITY sequence|amod|END_ENTITY	To this end we used a phosphorothioate double-stranded decoy oligodeoxynucleotide -LRB- ODN -RRB- carrying the NF-kappa_B / Rel - consensus sequence .
11160275	0	Rel	11,14	NF-kappa_B	0,10	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	participation|compound|START_ENTITY lymphoid|nsubj|participation END_ENTITY|parataxis|lymphoid	NF-kappa_B / Rel participation in the lymphokine-dependent proliferation of T lymphoid cells .
11714807	0	Rel	19,22	NF-kappa_B	8,18	Rel	NF-kappa B	5966	4790	Gene	Gene	site|compound|START_ENTITY cooperates|nsubj|site END_ENTITY|parataxis|cooperates	A novel NF-kappa_B / Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor .
11912207	0	Rel	30,33	NF-kappa_B	19,29	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	p65|amod|START_ENTITY p65|dep|Opposing Opposing|nmod|END_ENTITY	Opposing roles for NF-kappa_B / Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta .
14634280	0	Rel	81,84	NF-kappa_B	70,80	Rel	NF-kappa B	5966	4790	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Regulation of cell survival in CD95-induced T cell apoptosis : role of NF-kappa_B / Rel transcription factors .
7479915	0	Rel	27,30	NF-kappa_B	16,26	Rel	NF-kappa B	5966	4790	Gene	Gene	factors|compound|START_ENTITY Coexpression|dep|factors Coexpression|nmod|END_ENTITY	Coexpression of NF-kappa_B / Rel and Sp1 transcription factors in human_immunodeficiency_virus_1-induced , dendritic_cell-T-cell_syncytia .
7508926	0	Rel	40,43	NF-kappa_B	29,39	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of transcription factor NF-kappa_B / Rel in induction of nitric_oxide synthase .
7537042	0	Rel	108,111	NF-kappa_B	97,107	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Transcriptional inhibition of the inducible nitric_oxide synthase gene by competitive binding of NF-kappa_B / Rel proteins .
7559449	0	Rel	104,107	NF-kappa_B	93,103	Rel	NF-kappa B	5966	4790	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Regulation of the human P-selectin promoter by Bcl-3 and specific homodimeric members of the NF-kappa_B / Rel family .
7594464	0	Rel	111,114	NF-kappa_B	100,110	Rel	NF-kappa B	5966	4790	Gene	Gene	Stimulation|parataxis|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa_B / Rel protein complexes .
7692309	0	Rel	20,23	NF-kappa_B	9,19	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	factors|compound|START_ENTITY responsible|nsubj|factors END_ENTITY|parataxis|responsible	Distinct NF-kappa_B / Rel transcription factors are responsible for tissue-specific and inducible gene activation .
7769726	0	Rel	96,99	NF-kappa_B	85,95	Rel	NF-kappa B	5966	4790	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of LMP1 in epithelial cells leads to the activation of a select subset of NF-kappa_B / Rel family proteins .
7926758	0	Rel	58,61	NF-kappa_B	47,57	Rel	NF-kappa B	5966	4790	Gene	Gene	factors|compound|START_ENTITY factors|nummod|END_ENTITY	The v-abl tyrosine kinase negatively regulates NF-kappa_B / Rel factors and blocks kappa gene transcription in pre-B lymphocytes .
7935451	0	Rel	64,67	NF-kappa_B	53,63	Rel	NF-kappa B	5966	4790	Gene	Gene	involves|nsubj|START_ENTITY mediated|parataxis|involves mediated|nsubj|activation activation|nmod|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
7941339	0	Rel	63,66	NF-kappa_B	52,62	Rel	NF-kappa B	5966	4790	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Subcellular redistribution of HTLV-1 Tax protein by NF-kappa_B / Rel transcription factors .
7982981	0	Rel	60,63	NF-kappa_B	49,59	Rel	NF-kappa B	5966	4790	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	In vitro study of functional involvement of Sp1 , NF-kappa_B / Rel , and AP1 in phorbol_12-myristate_13-acetate-mediated HIV-1 long terminal repeat activation .
8035813	0	Rel	35,38	NF-kappa_B	24,34	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY induction|dep|proteins induction|nmod|END_ENTITY	Sequential induction of NF-kappa_B / Rel family proteins during B-cell terminal differentiation .
8152286	0	Rel	30,33	NF-kappa_B	19,29	Rel	NF-kappa B	5966	4790	Gene	Gene	proteins|compound|START_ENTITY induction|dep|proteins induction|nmod|END_ENTITY	Virus induction of NF-kappa_B / Rel proteins and type I interferon gene expression in myelomonoblastic cells .
8152812	0	Rel	34,37	NF-kappa_B	23,33	Rel	NF-kappa B	5966	4790	Gene	Gene	complexes|compound|START_ENTITY necrosis|nsubj|complexes Activation|parataxis|necrosis Activation|nmod|END_ENTITY	Activation of multiple NF-kappa_B / Rel DNA-binding complexes by tumor necrosis factor .
8164652	0	Rel	177,180	NF-kappa_B	12,22	Rel	NF-kappa B	5966	4790	Gene	Gene	subunits|compound|START_ENTITY cell-specific|nmod|subunits dependent|nmod|cell-specific Function|parataxis|dependent Function|nmod|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	Rel	177,180	NF-kappa_B	166,176	Rel	NF-kappa B	5966	4790	Gene	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	Rel	23,26	NF-kappa_B	12,22	Rel	NF-kappa B	5966	4790	Gene	Gene	sites|compound|START_ENTITY dependent|nsubj|sites Function|parataxis|dependent Function|nmod|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	Rel	23,26	NF-kappa_B	166,176	Rel	NF-kappa B	5966	4790	Gene	Gene	sites|compound|START_ENTITY dependent|nsubj|sites dependent|nmod|cell-specific cell-specific|nmod|subunits subunits|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8321203	0	Rel	84,87	NF-kappa_B	45,55	Rel	NF-kappa B	5966	4790	Gene	Gene	interaction|compound|START_ENTITY associations|dep|interaction associations|nmod|members members|compound|END_ENTITY	Functional and physical associations between NF-kappa_B and C/EBP family members : a Rel domain-bZIP interaction .
8530134	0	Rel	36,39	NF-kappa_B	25,35	Rel	NF-kappa B	5966	4790	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Multi-step activation of NF-kappa_B / Rel transcription factors .
8758892	0	Rel	31,34	NF-kappa_B	20,30	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY inducing|nsubj|activity END_ENTITY|parataxis|inducing	TGF_beta_1 inhibits NF-kappa_B / Rel activity inducing apoptosis of B cells : transcriptional activation of I_kappa_B_alpha .
8887449	0	Rel	73,76	NF-kappa_B	62,72	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY Effects|dep|activity Effects|nmod|END_ENTITY	Effects of vomitoxin -LRB- deoxynivalenol -RRB- on transcription factor NF-kappa_B / Rel binding activity in murine EL-4_thymoma and primary CD4 + T cells .
8899295	0	Rel	56,59	NF-kappa_B	45,55	Rel	NF-kappa B	5966	4790	Gene	Gene	proteins|compound|START_ENTITY inhibitors|dep|proteins inhibitors|nmod|END_ENTITY	Biological and biochemical inhibitors of the NF-kappa_B / Rel proteins and cytokine synthesis .
9679644	0	Rel	25,28	NF-kappa_B	14,24	Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Inhibition of NF-kappa_B / Rel nuclear translocation by dexamethasone : mechanism for the inhibition of iNOS gene expression .
7936632	0	Rel	41,44	NF-kappa_B_p65	64,78	Rel	NF-kappa B p65	5966	5970	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa_B_p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription .
9920279	0	Rel	22,25	Nuclear_factor-kappaB	0,21	Rel	Nuclear factor-kappaB	5966	4790	Gene	Gene	proteins|compound|START_ENTITY proteins|nummod|END_ENTITY	Nuclear_factor-kappaB / Rel proteins : a point of convergence of signalling pathways relevant in neuronal function and dysfunction .
8164652	0	Rel	177,180	Rel	23,26	Rel	Rel	5966	5966	Gene	Gene	subunits|compound|START_ENTITY cell-specific|nmod|subunits dependent|nmod|cell-specific dependent|nsubj|sites sites|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
8164652	0	Rel	23,26	Rel	177,180	Rel	Rel	5966	5966	Gene	Gene	sites|compound|START_ENTITY dependent|nsubj|sites dependent|nmod|cell-specific cell-specific|nmod|subunits subunits|compound|END_ENTITY	Function of NF-kappa_B / Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa_B / Rel subunits .
7729529	0	Rel	88,91	arachidonate_12-lipoxygenase	40,68	Rel	arachidonate 12-lipoxygenase	5966	239	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	The transcriptional regulation of human arachidonate_12-lipoxygenase gene by NF_kappa_B / Rel .
10770796	0	Rel	0,3	interferon_regulatory_factor_4	12,42	Rel	interferon regulatory factor 4	5966	3662	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Rel induces interferon_regulatory_factor_4 -LRB- IRF-4 -RRB- expression in lymphocytes : modulation of interferon-regulated gene expression by rel/nuclear factor kappaB .
19058135	0	RelA	46,50	DDX1	26,30	RelA	DDX1	5970	1653	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription .
19064995	0	RelA	121,125	IL-8	173,177	RelA	IL-8	5970	3576	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Pseudomonas_aeruginosa induces interleukin-8 -LRB- IL-8 -RRB- gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding _ protein_beta to the IL-8 promoter .
19064995	0	RelA	121,125	IL-8	46,50	RelA	IL-8	5970	3576	Gene	Gene	recruitment|nmod|START_ENTITY induces|nmod|recruitment induces|dobj|expression expression|amod|interleukin-8 interleukin-8|dep|END_ENTITY	Pseudomonas_aeruginosa induces interleukin-8 -LRB- IL-8 -RRB- gene expression in human conjunctiva through the recruitment of both RelA and CCAAT/enhancer-binding _ protein_beta to the IL-8 promoter .
19135383	0	RelA	203,207	IL-8	92,96	RelA	IL-8	5970	3576	Gene	Gene	subunit|compound|START_ENTITY phosphorylation|nmod|subunit involves|dobj|phosphorylation IL-1beta-stimulated|acl:relcl|involves infrared|nmod|IL-1beta-stimulated infrared|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Effects of linear polarized infrared light irradiation on the transcriptional regulation of IL-8 expression in IL-1beta-stimulated human rheumatoid synoviocytes involves phosphorylation of the NF-kappaB RelA subunit .
8207232	0	RelA	75,79	IL-8	46,50	RelA	IL-8	5970	3576	Gene	Gene	p65|appos|START_ENTITY transcriptional|nmod|p65 transcriptional|dobj|activation activation|nmod|gene gene|compound|END_ENTITY	Synergistic transcriptional activation of the IL-8 gene by NF-kappa_B p65 -LRB- RelA -RRB- and NF-IL-6 .
9135156	0	RelA	68,72	I_kappa_B_epsilon	0,17	RelA	I kappa B epsilon	5970	9641	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	I_kappa_B_epsilon , a novel member of the I kappa B family , controls RelA and cRel NF-kappa_B activity .
9621019	0	RelA	25,29	IkappaBbeta	108,119	RelA	IkappaBbeta	5970	4793	Gene	Gene	activation|nmod|START_ENTITY involves|nsubj|activation involves|dobj|END_ENTITY	Persistent activation of RelA by respiratory_syncytial_virus involves protein_kinase_C , underphosphorylated IkappaBbeta , and sequestration of protein phosphatase 2A by the viral phosphoprotein .
10496024	0	RelA	33,37	NF-kappa_B	22,32	RelA	NF-kappa B	5970	4790	Gene	Gene	activated|nsubj|START_ENTITY END_ENTITY|parataxis|activated	-LSB- Transcription factor NF-kappa_B / RelA are constitutively activated and localized in the cell nuclei of E1A + cHa-Ras transformants -RSB- .
7603567	0	RelA	63,67	NF-kappa_B	81,91	RelA	NF-kappa B	19697(Tax:10090)	18033(Tax:10090)	Gene	Gene	component|compound|START_ENTITY component|nmod|END_ENTITY	Embryonic_lethality_and_liver_degeneration in mice lacking the RelA component of NF-kappa_B .
8108414	0	RelA	48,52	NF-kappa_B	22,32	RelA	NF-kappa B	5970	4790	Gene	Gene	p65|compound|START_ENTITY transactivator|dobj|p65 transactivator|nsubj|Autoregulation Autoregulation|nmod|END_ENTITY	Autoregulation of the NF-kappa_B transactivator RelA -LRB- p65 -RRB- by multiple cytoplasmic inhibitors containing ankyrin motifs .
16192349	0	RelA	0,4	RelB	19,23	RelA	RelB	19697(Tax:10090)	19698(Tax:10090)	Gene	Gene	repression|compound|START_ENTITY repression|nmod|activity activity|compound|END_ENTITY	RelA repression of RelB activity induces selective gene activation downstream of TNF receptors .
10894954	0	RelA	55,59	Rela	70,74	RelA	Rela	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosome location of the mouse RelA p65 gene -LRB- Rela -RRB- .
21131967	0	RelA	40,44	SETD6	48,53	RelA	SETD6	5970	79918	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Lysine methylation of the NF-kB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kB signaling .
19254740	0	RelA	61,65	SOX9	29,33	RelA	SOX9	5970	6662	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells .
21350211	0	RelA	29,33	c-Jun_N-terminal_kinase_1	49,74	RelA	c-Jun N-terminal kinase 1	19697(Tax:10090)	26419(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Disturbed blood flow induces RelA expression via c-Jun_N-terminal_kinase_1 : a novel mode of NF-kB regulation that promotes arterial_inflammation .
17904523	0	RelA	40,44	gankyrin	16,24	RelA	gankyrin	5970	5716	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity .
17650800	0	RelA	91,95	matrix_metalloproteinase_2	35,61	RelA	matrix metalloproteinase 2	309165(Tax:10116)	81686(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of curcumin on activity of matrix_metalloproteinase_2 , 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome_proliferator-activated_receptor_gamma signal -RSB- .
18040287	0	RelA	30,34	p28_GANK	12,20	RelA	p28 GANK	5970	5716	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Oncoprotein p28_GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export .
9788595	0	RelA	49,53	p300	89,93	RelA	p300	5970	2033	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300 .
10894954	0	RelA	55,59	p65	60,63	RelA	p65	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Genomic structure and chromosome location of the mouse RelA p65 gene -LRB- Rela -RRB- .
12509469	0	RelA	14,18	p65	20,23	RelA	p65	5970	5970	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of RelA -LRB- p65 -RRB- function by the large subunit of replication factor C .
18631125	0	RelA	18,22	p65	24,27	RelA	p65	5970	5970	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the RelA -LRB- p65 -RRB- transactivation domain .
21737676	0	RelA	12,16	p65	18,21	RelA	p65	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of RelA -LRB- p65 -RRB- threonine 505 phosphorylation in the regulation of cell growth , survival , and migration .
25777430	0	RelA	27,31	p65	22,25	RelA	p65	5970	5970	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Nuclear expression of p65 -LRB- RelA -RRB- in patients receiving post-operative radiotherapy for locally advanced squamous_cell_carcinoma_of_the_head_and_neck .
25868613	0	RelA	27,31	p65	22,25	RelA	p65	5970	5970	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Nuclear expression of p65 -LRB- RelA -RRB- in patients receiving post-operative radiotherapy for locally advanced squamous_cell_carcinoma_of_the_head_and_neck .
16769540	0	RelA	26,30	p65_NF-kappaB	12,25	RelA	p65 NF-kappaB	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of p65_NF-kappaB / RelA in pancreatitis-induced Kupffer cell apoptosis .
24839547	0	RelB	0,4	Bcl-xl	15,21	RelB	Bcl-xl	19698(Tax:10090)	12048(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	RelB regulates Bcl-xl expression and the irradiation-induced apoptosis of murine prostate_cancer cells .
25943190	0	RelB	48,52	COX-2	144,149	RelB	COX-2	5971	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Decreased expression of the NF-kB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression .
25943190	0	RelB	48,52	COX-2	144,149	RelB	COX-2	5971	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Decreased expression of the NF-kB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression .
21071440	0	RelB	15,19	Csf2	27,31	RelB	Csf2	5971	1437	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage_colony-stimulating_factor .
26378077	0	RelB	64,68	Deleted_in_Breast_Cancer_1	0,26	RelB	Deleted in Breast Cancer 1	19698(Tax:10090)	56710(Tax:10090)	Gene	Gene	Suppresses|nmod|START_ENTITY Suppresses|nsubj|END_ENTITY	Deleted_in_Breast_Cancer_1 Suppresses B Cell Activation through RelB and Is Regulated by IKKa Phosphorylation .
16810633	0	RelB	36,40	IFN-alpha	44,53	RelB	IFN-alpha	5971	3439	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	A role for the transcription factor RelB in IFN-alpha production and in IFN-alpha-stimulated cross-priming .
18688039	0	RelB	0,4	IkappaB_Kinase-alpha	36,56	RelB	IkappaB Kinase-alpha	19698(Tax:10090)	12675(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	RelB is differentially regulated by IkappaB_Kinase-alpha in B cells and mouse lung by cigarette smoke .
12202396	0	RelB	83,87	NF-kappaB	47,56	RelB	NF-kappaB	19698(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|nsubj|expression switch|parataxis|inhibits switch|nmod|END_ENTITY	Regulation of Ig class switch recombination by NF-kappaB : retroviral expression of RelB in activated B cells inhibits switching to IgG1 , but not to IgE .
17446175	0	RelB	47,51	NF-kappaB	52,61	RelB	NF-kappaB	19698(Tax:10090)	18033(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis .
22968463	0	RelB	58,62	NIK	37,40	RelB	NIK	5971	9020	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Hodgkin_lymphoma requires stabilized NIK and constitutive RelB expression for survival .
16192349	0	RelB	19,23	RelA	0,4	RelB	RelA	19698(Tax:10090)	19697(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY repression|nmod|activity repression|compound|END_ENTITY	RelA repression of RelB activity induces selective gene activation downstream of TNF receptors .
26287732	0	RelB	23,27	TNF	0,3	RelB	TNF	5971	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	TNF Induction of NF-kB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression .
24472607	0	RelB	24,28	miR-146a	48,56	RelB	miR-146a	5971	406938	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	The NF-kB family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts .
20686703	0	RelB	37,41	tumor_necrosis_factor-alpha	94,121	RelB	tumor necrosis factor-alpha	5971	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Nuclear_factor-kappa_B family member RelB inhibits human_immunodeficiency_virus-1 Tat-induced tumor_necrosis_factor-alpha production .
22592403	0	Rel_A	0,5	p65	6,9	Rel A	p65	5970	5970	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	Rel_A / p65 is required for cytokine-induced myotube_atrophy .
10894954	0	Rela	70,74	RelA	55,59	Rela	RelA	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure and chromosome location of the mouse RelA p65 gene -LRB- Rela -RRB- .
10894954	0	Rela	70,74	p65	60,63	Rela	p65	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and chromosome location of the mouse RelA p65 gene -LRB- Rela -RRB- .
19285023	0	Related_transcriptional_enhancer_factor-1	0,41	fibroblast_growth_factor_receptor-1	50,85	Related transcriptional enhancer factor-1	fibroblast growth factor receptor-1	21679(Tax:10090)	14182(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Related_transcriptional_enhancer_factor-1 induces fibroblast_growth_factor_receptor-1 expression in endothelial cells .
26970832	0	Relaxin-2	0,9	Flt1	22,26	Relaxin-2	Flt1	6019	2321	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Relaxin-2 and Soluble Flt1 Levels in Peripartum Cardiomyopathy : Results of the Multicenter IPAC Study .
25406021	0	Relaxin-3	24,33	Corticotropin-Releasing_Factor	73,103	Relaxin-3	Corticotropin-Releasing Factor	266997(Tax:10116)	81648(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Sex-Specific Effects of Relaxin-3 on Food Intake and Brain Expression of Corticotropin-Releasing_Factor in Rats .
21072619	0	Relaxin-3	0,9	INSL7	10,15	Relaxin-3	INSL7	266997(Tax:10116)	266997(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Relaxin-3 / INSL7 regulates the stress-response system in the rat hypothalamus .
24065955	0	Relaxin-3	0,9	RXFP3	10,15	Relaxin-3	RXFP3	117579	51289	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Relaxin-3 / RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control .
24297931	0	Relaxin-3	0,9	RXFP3	10,15	Relaxin-3	RXFP3	117579	51289	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|system system|compound|END_ENTITY	Relaxin-3 / RXFP3 system regulates alcohol-seeking .
24711793	0	Relaxin-3	0,9	RXFP3	10,15	Relaxin-3	RXFP3	117579	51289	Gene	Gene	START_ENTITY|dep|networks networks|nummod|END_ENTITY	Relaxin-3 / RXFP3 networks : an emerging target for the treatment of depression and other neuropsychiatric_diseases ?
25257104	0	Relaxin-3	0,9	RXFP3	121,126	Relaxin-3	RXFP3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|Implications Implications|nmod|role role|nmod|signalling signalling|compound|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
25849482	0	Relaxin-3	0,9	RXFP3	20,25	Relaxin-3	RXFP3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	Signalling|compound|START_ENTITY Signalling|appos|END_ENTITY	Relaxin-3 Receptor -LRB- RXFP3 -RRB- Signalling Mediates Stress-Related Alcohol Preference in Mice .
26023064	0	Relaxin-3	82,91	RXFP3	92,97	Relaxin-3	RXFP3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	Administration|nmod|START_ENTITY Deficiency|nmod|Administration Deficiency|compound|END_ENTITY	Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3 / RXFP3 Deficiency .
26023064	0	Relaxin-3	82,91	RXFP3	92,97	Relaxin-3	RXFP3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	Administration|nmod|START_ENTITY Deficiency|nmod|Administration Deficiency|compound|END_ENTITY	Sensitivity to Chronic Methamphetamine Administration and Withdrawal in Mice with Relaxin-3 / RXFP3 Deficiency .
25257104	0	Relaxin-3	0,9	Rxfp3	20,25	Relaxin-3	Rxfp3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
26278401	0	Relaxin-3	0,9	Rxfp3	20,25	Relaxin-3	Rxfp3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY reduces|nsubj|receptor reduces|dep|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene deletion reduces operant sucrose - but not alcohol-responding in mice .
26278401	0	Relaxin-3	0,9	Rxfp3	20,25	Relaxin-3	Rxfp3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY reduces|nsubj|receptor reduces|dep|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene deletion reduces operant sucrose - but not alcohol-responding in mice .
24947515	0	Relish	101,107	DMAP1	24,29	Relish	DMAP1	41087(Tax:7227)	37339(Tax:7227)	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	The chromatin regulator DMAP1 modulates activity of the nuclear factor B -LRB- NF-B -RRB- transcription factor Relish in the Drosophila innate immune response .
11872802	0	Relish	62,68	peptidoglycan_recognition_protein	18,51	Relish	peptidoglycan recognition protein	41087(Tax:7227)	32534(Tax:7227)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Requirement for a peptidoglycan_recognition_protein -LRB- PGRP -RRB- in Relish activation and antibacterial immune responses in Drosophila .
18514414	0	Reln	83,87	Dab1	102,106	Reln	Dab1	19699(Tax:10090)	13131(Tax:10090)	Gene	Gene	mutations|dep|START_ENTITY mutations|dep|END_ENTITY	Pafah1b2 mutations suppress the development of hydrocephalus in compound Pafah1b1 ; Reln and Pafah1b1 ; Dab1 mutant mice .
12919743	0	Ren	79,82	PCNA	26,30	Ren	PCNA	5972	5111	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Dual interaction of plant PCNA with geminivirus replication accessory protein -LRB- Ren -RRB- and viral replication protein -LRB- Rep -RRB- .
12919743	0	Ren	79,82	Rep	115,118	Ren	Rep	5972	956401(Tax:10831)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Dual interaction of plant PCNA with geminivirus replication accessory protein -LRB- Ren -RRB- and viral replication protein -LRB- Rep -RRB- .
9547018	0	Ren-2	100,105	angiotensin_II	11,25	Ren-2	angiotensin II	19702(Tax:10090)	24179(Tax:10116)	Gene	Gene	cultures|nmod|START_ENTITY END_ENTITY|nmod|cultures	Endogenous angiotensin_II and cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic_rats .
25250989	0	Renin	48,53	Angiotensin_II	0,14	Renin	Angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	Receptor|compound|START_ENTITY Expression|nmod|Receptor Increases|dobj|Expression Increases|nsubj|END_ENTITY	Angiotensin_II Increases the Expression of -LRB- Pro -RRB- Renin Receptor During Low-Salt Conditions .
26495141	0	Renin	42,47	REN	28,31	Renin	REN	5972	5972	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Genetic Variants of C-5312T REN Increased Renin Levels and Diastolic Blood Pressure Response to Angiotensin Receptor Blockers .
9353383	0	Renin	0,5	angiotensin-converting_enzyme	10,39	Renin	angiotensin-converting enzyme	24715(Tax:10116)	24310(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Renin vs. angiotensin-converting_enzyme inhibition in the rat : consequences for plasma and renal tissue angiotensin .
19451703	0	Renin	0,5	angiotensin_II	104,118	Renin	angiotensin II	5972	183	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|pathways pathways|acl|implicated implicated|nmod|cells cells|nmod|production production|amod|END_ENTITY	Renin and prorenin activate pathways implicated in organ damage in human mesangial cells independent of angiotensin_II production .
2412013	0	Renin	0,5	angiotensin_II	57,71	Renin	angiotensin II	5972	183	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|dep|use use|acl|understanding understanding|dobj|role role|nmod|END_ENTITY	Renin inhibitors : their use in understanding the role of angiotensin_II as a pressor hormone .
3516662	0	Renin	0,5	angiotensin_II	41,55	Renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	coexists|nsubj|START_ENTITY coexists|nmod|END_ENTITY	Renin in the rat pituitary coexists with angiotensin_II and depends on testosterone .
8385523	0	Renin	0,5	angiotensin_II	48,62	Renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	release|compound|START_ENTITY induced|nsubj|release induced|nmod|losartan losartan|appos|antagonist antagonist|amod|END_ENTITY	Renin release induced by losartan -LRB- DuP_753 -RRB- , an angiotensin_II receptor antagonist .
8829212	0	Renin	0,5	angiotensin_II	96,110	Renin	angiotensin II	5972	183	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|acl:relcl|independent independent|nmod|formation formation|amod|END_ENTITY	Renin stimulates decidual prostaglandin production via a novel mechanism that is independent of angiotensin_II formation .
26607294	0	Renin	0,5	angiotensinogen	6,21	Renin	angiotensinogen	5972	183	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|compound|END_ENTITY	Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent : a systematic review .
6385771	0	Renin	0,5	angiotensinogen	68,83	Renin	angiotensinogen	5972	183	Gene	Gene	cleavage|compound|START_ENTITY substrate|nsubj|cleavage substrate|xcomp|analogous analogous|nmod|END_ENTITY	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
24768585	0	Renin	0,5	mTOR	35,39	Renin	mTOR	5972	21977(Tax:10090)	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Renin angiotensin system modulates mTOR pathway through AT2R in HIVAN .
744127	0	Renin	0,5	parathyroid_hormone	17,36	Renin	parathyroid hormone	403838(Tax:9615)	403986(Tax:9615)	Gene	Gene	release|nsubj|START_ENTITY release|nmod|END_ENTITY	Renin release by parathyroid_hormone in the dog .
1026364	0	Renin	0,5	renin	7,12	Renin	renin	5972	5972	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Renin , renin substrate and angiotensin_II concentration in renal venous blood .
6385771	0	Renin	0,5	renin	33,38	Renin	renin	5972	5972	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
11098137	0	Renin	0,5	renin-binding_protein	51,72	Renin	renin-binding protein	5972	5973	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|2-epimerase 2-epimerase|appos|END_ENTITY	Renin inhibits N-acetyl-D-glucosamine 2-epimerase -LRB- renin-binding_protein -RRB- .
12919743	0	Rep	115,118	PCNA	26,30	Rep	PCNA	956401(Tax:10831)	5111	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Dual interaction of plant PCNA with geminivirus replication accessory protein -LRB- Ren -RRB- and viral replication protein -LRB- Rep -RRB- .
12919743	0	Rep	115,118	Ren	79,82	Rep	Ren	956401(Tax:10831)	5972	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Dual interaction of plant PCNA with geminivirus replication accessory protein -LRB- Ren -RRB- and viral replication protein -LRB- Rep -RRB- .
24852074	0	Repeat_associated_non-ATG	0,25	RAN	27,30	Repeat associated non-ATG	RAN	5901	5901	Gene	Gene	translation|amod|START_ENTITY translation|appos|END_ENTITY	Repeat_associated_non-ATG -LRB- RAN -RRB- translation : new starts in microsatellite expansion disorders .
10656792	1	Replication_factor_C	30,50	DNA_polymerase_alpha	81,101	Replication factor C	DNA polymerase alpha	5981	5422	Gene	Gene	abrogates|nsubj|START_ENTITY abrogates|nmod|END_ENTITY	Replication_factor_C abrogates primer synthesis by DNA_polymerase_alpha at a critical length .
25541153	0	Replication_factor_C3	0,21	CREB	27,31	Replication factor C3	CREB	5983	1385	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Replication_factor_C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA .
15273694	0	Replication_protein_A	0,21	AID	37,40	Replication protein A	AID	6117	57379	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Replication_protein_A interacts with AID to promote deamination of somatic hypermutation targets .
11063722	0	Replication_protein_A1	0,22	endothelial_nitric_oxide_synthase	52,85	Replication protein A1	endothelial nitric oxide synthase	6117	4846	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|transcription transcription|nmod|gene gene|amod|END_ENTITY	Replication_protein_A1 reduces transcription of the endothelial_nitric_oxide_synthase gene containing a -786 T -- > C mutation associated with coronary_spastic_angina .
22884151	0	Repressor_of_GATA-3	0,19	inducible_costimulator	101,123	Repressor of GATA-3	inducible costimulator	27033	29851	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Repressor_of_GATA-3 can negatively regulate the expression of T cell cytokines through modulation on inducible_costimulator .
19180575	0	Reptin	21,27	RPAP3	0,5	Reptin	RPAP3	10856	79657	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage .
25957047	0	Reptin	0,6	p65	33,36	Reptin	p65	10856	5970	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Reptin physically interacts with p65 and represses NF-kB activation .
17325205	0	Rer1p	0,5	APH-1	20,25	Rer1p	APH-1	11079	51107	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway .
9152025	0	Rer1p	16,21	Sec12p	0,6	Rer1p	Sec12p	850354(Tax:4932)	855760(Tax:4932)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Sec12p requires Rer1p for sorting to coatomer -LRB- COPI -RRB- - coated vesicles and retrieval to the ER .
11574398	0	Resistin	0,8	Fizz3	11,16	Resistin	Fizz3	56729	56729	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Resistin / Fizz3 expression in relation to obesity and peroxisome_proliferator-activated_receptor-gamma action in humans .
25128719	0	Resistin	0,8	Insulin	10,17	Resistin	Insulin	56729	3630	Gene	Gene	START_ENTITY|dep|resistance resistance|amod|END_ENTITY	Resistin : Insulin resistance to malignancy .
23827175	0	Resistin	0,8	SIRT1	17,22	Resistin	SIRT1	57264(Tax:10090)	93759(Tax:10090)	Gene	Gene	impairs|nsubj|START_ENTITY impairs|dobj|function function|compound|END_ENTITY	Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes .
23975745	0	Resistin	0,8	adiponectin	76,87	Resistin	adiponectin	56729	9370	Gene	Gene	START_ENTITY|dep|modification modification|nmod|END_ENTITY	Resistin and all-cause and cardiovascular mortality : effect modification by adiponectin in end-stage_kidney_disease patients .
27079485	0	Resistin	0,8	adiponectin	53,64	Resistin	adiponectin	56729	9370	Gene	Gene	predictor|nsubj|START_ENTITY predictor|parataxis|predictor predictor|nsubj|ratio ratio|compound|END_ENTITY	Resistin is a predictor of asthma risk and resistin : adiponectin ratio is a negative predictor of lung function in asthma .
11786595	0	Resistin	0,8	insulin	63,70	Resistin	insulin	56729	3630	Gene	Gene	expression|compound|START_ENTITY related|nsubjpass|expression related|nmod|resistance resistance|compound|END_ENTITY	Resistin gene expression in human adipocytes is not related to insulin resistance .
14671216	0	Resistin	0,8	insulin	67,74	Resistin	insulin	56729	3630	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|expression expression|nmod|END_ENTITY	Resistin and type 2 diabetes : regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes .
22934726	0	Resistin	0,8	insulin	101,108	Resistin	insulin	56729	3630	Gene	Gene	expression|compound|START_ENTITY expression|nmod|resistance resistance|compound|END_ENTITY	Resistin gene expression in visceral adipose tissue of postmenopausal women and its association with insulin resistance .
17597619	0	Resistin	0,8	insulin_receptor	24,40	Resistin	insulin receptor	56729	3643	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Resistin down-regulates insulin_receptor expression , and modulates cell viability in rodent pancreatic beta-cells .
23652833	0	Resistin	0,8	vascular_endothelial_growth_factor	36,70	Resistin	vascular endothelial growth factor	56729	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Resistin promotes the expression of vascular_endothelial_growth_factor in ovary_carcinoma cells .
25418473	0	Response_gene_to_complement_32	0,30	RGC-32	32,38	Response gene to complement 32	RGC-32	28984	28984	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Response_gene_to_complement_32 -LRB- RGC-32 -RRB- expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4 .
21307346	0	Response_gene_to_complement_32	0,30	Smad3	46,51	Response gene to complement 32	Smad3	28984	4088	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Response_gene_to_complement_32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells .
9467954	0	Ret	18,21	GDNF	36,40	Ret	GDNF	5979	2668	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Calcium-dependent Ret activation by GDNF and neurturin .
11746356	0	Ret	99,102	GFRalpha-1	49,59	Ret	GFRalpha-1	19713(Tax:10090)	14585(Tax:10090)	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|amod|END_ENTITY	Evidence for a ligand-specific signaling through GFRalpha-1 , but not GFRalpha-2 , in the absence of Ret .
26047795	0	Ret	41,44	LDL_Receptor-Related_Protein_6	0,30	Ret	LDL Receptor-Related Protein 6	19713(Tax:10090)	16974(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	LDL_Receptor-Related_Protein_6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic_Dysplasia .
26490873	0	Ret	48,51	Nurr1	0,5	Ret	Nurr1	19713(Tax:10090)	18227(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Ligands|dobj|Signaling Ligands|nsubj|END_ENTITY	Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate a-Synuclein Disrupted Gene Expression .
10536054	0	Ret	14,17	Phox2a	31,37	Ret	Phox2a	19713(Tax:10090)	11859(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of Ret - , p75 -LRB- NTR -RRB- - , Phox2a - , Phox2b - , and tyrosine_hydroxylase-immunoreactivity by undifferentiated neural crest-derived cells and different classes of enteric neurons in the embryonic mouse gut .
11313948	0	Ret	154,157	Shc	121,124	Ret	Shc	5979	6464	Gene	Gene	the|nmod|START_ENTITY evidence|nmod|the evidence|nmod|competition competition|nmod|END_ENTITY	The insulin_receptor_substrate _ -LRB- IRS -RRB- -1 recruits phosphatidylinositol_3-kinase to Ret : evidence for a competition between Shc and IRS-1 for the binding to Ret .
11313948	0	Ret	81,84	Shc	121,124	Ret	Shc	5979	6464	Gene	Gene	phosphatidylinositol_3-kinase|nmod|START_ENTITY _|amod|phosphatidylinositol_3-kinase _|dep|evidence evidence|nmod|competition competition|nmod|END_ENTITY	The insulin_receptor_substrate _ -LRB- IRS -RRB- -1 recruits phosphatidylinositol_3-kinase to Ret : evidence for a competition between Shc and IRS-1 for the binding to Ret .
8183561	0	Ret	30,33	Shc	64,67	Ret	Shc	5979	6464	Gene	Gene	tyrosine|compound|START_ENTITY versions|nmod|tyrosine kinases|nsubj|versions kinases|dobj|END_ENTITY	The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins .
9047384	0	Ret	38,41	Shc	18,21	Ret	Shc	5979	6464	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Identification of Shc docking site on Ret tyrosine kinase .
10208419	0	Ret	115,118	focal_adhesion_kinase	59,80	Ret	focal adhesion kinase	5979	5747	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Rho-dependent and - independent tyrosine phosphorylation of focal_adhesion_kinase , paxillin and p130Cas mediated by Ret kinase .
10493748	0	Ret	72,75	neurturin	20,29	Ret	neurturin	396107(Tax:9031)	428340(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY patterns|nmod|expression correlate|nmod|patterns correlate|nsubj|actions actions|nmod|END_ENTITY	Multiple actions of neurturin correlate with spatiotemporal patterns of Ret expression in developing chick cranial_ganglion_neurons .
9182803	0	Ret	75,78	neurturin	38,47	Ret	neurturin	5979	4902	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	TrnR2 , a novel receptor that mediates neurturin and GDNF signaling through Ret .
9192898	0	Ret	41,44	neurturin	65,74	Ret	neurturin	5979	4902	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|form form|dobj|receptor receptor|compound|END_ENTITY	A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor .
17380130	0	Ret	24,27	p53	78,81	Ret	p53	19713(Tax:10090)	22060(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1 / p53 pathway , preventing tumor growth .
11786211	0	Ret	14,17	receptor_tyrosine_kinase	18,42	Ret	receptor tyrosine kinase	24716(Tax:10116)	24716(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of Ret receptor_tyrosine_kinase after transient forebrain_ischemia is modulated by glial_cell_line-derived_neurotrophic_factor in rat hippocampus .
16879925	0	Ret	12,15	receptor_tyrosine_kinase	16,40	Ret	receptor tyrosine kinase	24716(Tax:10116)	24716(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of Ret receptor_tyrosine_kinase in dopaminergic neuron development .
12691732	0	Reticulon_4	6,17	Nogo	0,4	Reticulon 4	Nogo	68585(Tax:10090)	68585(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nogo -LRB- Reticulon_4 -RRB- expression in innervated and denervated mouse skeletal muscle .
21928830	0	Retinal_degeneration_3	0,22	RD3	24,27	Retinal degeneration 3	RD3	343035	343035	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Retinal_degeneration_3 -LRB- RD3 -RRB- protein inhibits catalytic activity of retinal_membrane_guanylyl_cyclase -LRB- RetGC -RRB- and its stimulation by activating proteins .
7997248	0	Retinoblastoma	0,14	CD74	45,49	Retinoblastoma	CD74	5925	972	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Retinoblastoma protein regulation of surface CD74 -LRB- invariant chain -RRB- expression in breast_carcinoma cells .
17251548	0	Retinoblastoma	0,14	COP9	41,45	Retinoblastoma	COP9	5925	10920	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Retinoblastoma protein regulation by the COP9 signalosome .
9591776	0	Retinoblastoma	0,14	SP1	39,42	Retinoblastoma	SP1	5925	6667	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate_reductase promoter .
8344391	0	Retinoic_acid-induced_heparin-binding_factor	0,44	RIHB	46,50	Retinoic acid-induced heparin-binding factor	RIHB	423196(Tax:9031)	423196(Tax:9031)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Retinoic_acid-induced_heparin-binding_factor -LRB- RIHB -RRB- mRNA and protein are strongly induced in chick embryo chondrocytes treated with retinoic_acid .
18523264	0	Retinoic_acid-inducible_gene-I	0,30	TNF-alpha	64,73	Retinoic acid-inducible gene-I	TNF-alpha	230073(Tax:10090)	21926(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Retinoic_acid-inducible_gene-I mediates late phase induction of TNF-alpha by lipopolysaccharide .
15181474	0	Retinoic_acid-inducible_gene-I	0,30	interferon-gamma	45,61	Retinoic acid-inducible gene-I	interferon-gamma	23586	3458	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Retinoic_acid-inducible_gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells .
18258269	0	Retinoic_acid-inducible_gene-I	0,30	interferon-gamma	45,61	Retinoic acid-inducible gene-I	interferon-gamma	23586	3458	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Retinoic_acid-inducible_gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells .
15612946	0	Retinoic_acid-inducible_gene-I	0,30	interleukin-1beta	45,62	Retinoic acid-inducible gene-I	interleukin-1beta	23586	3553	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Retinoic_acid-inducible_gene-I is induced by interleukin-1beta in cultured human gingival fibroblasts .
8149483	0	Retinoic_acid_nuclear_receptors	0,31	retinoic_acid_nuclear_receptors	77,108	Retinoic acid nuclear receptors	retinoic acid nuclear receptors	19401(Tax:10090)	19401(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Retinoic_acid_nuclear_receptors and tumor promotion : decreased expression of retinoic_acid_nuclear_receptors by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate .
7739532	0	Retinoic_acid_receptor_alpha	0,28	v-myb	58,63	Retinoic acid receptor alpha	v-myb	5914	4602	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Retinoic_acid_receptor_alpha suppresses transformation by v-myb .
12969790	0	Retinoid-X-receptor_alpha	0,25	RXRalpha	27,35	Retinoid-X-receptor alpha	RXRalpha	6256	6256	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Retinoid-X-receptor_alpha -LRB- RXRalpha -RRB- expression during laryngeal carcinogenesis : detrimental or beneficial event ?
26184991	0	Retinoid-related_orphan_receptor_alpha	0,38	RORA	40,44	Retinoid-related orphan receptor alpha	RORA	6095	6095	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Retinoid-related_orphan_receptor_alpha -LRB- RORA -RRB- gene variation is associated with trait depression .
21709632	0	Retinoid_X_Receptor-alpha	81,106	RXR-alpha	108,117	Retinoid X Receptor-alpha	RXR-alpha	6256	6256	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Correlation of Peroxisome_Proliferator-Activated_Receptor-gamma -LRB- PPAR-gamma -RRB- and Retinoid_X_Receptor-alpha -LRB- RXR-alpha -RRB- expression with clinical risk factors in patients with advanced carotid_atherosclerosis .
18713813	0	Retinoid_X_receptor_beta	0,24	RXRB	26,30	Retinoid X receptor beta	RXRB	20182(Tax:10090)	20182(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Retinoid_X_receptor_beta -LRB- RXRB -RRB- expression in Sertoli cells controls cholesterol homeostasis and spermiation .
18777500	0	Retinol-binding_protein_4	0,25	RBP-4	27,32	Retinol-binding protein 4	RBP-4	5950	5950	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Retinol-binding_protein_4 -LRB- RBP-4 -RRB- levels do not change after oral glucose tolerance test and after dexamethasone , but correlate with some indices of insulin resistance in humans .
19816414	0	Retinol-binding_protein_4	0,25	RBP4	27,31	Retinol-binding protein 4	RBP4	5950	5950	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dep|END_ENTITY	Retinol-binding_protein_4 -LRB- RBP4 -RRB- protein expression is increased in omental adipose tissue of severely obese patients .
17299074	0	Retinol-binding_protein_4	0,25	insulin	45,52	Retinol-binding protein 4	insulin	5950	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Retinol-binding_protein_4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes .
18362299	0	Retinol-binding_protein_4	0,25	insulin	45,52	Retinol-binding protein 4	insulin	5950	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Retinol-binding_protein_4 is associated with insulin resistance , but appears unsuited for metabolic screening in women with polycystic_ovary_syndrome .
21741059	0	Retinol-binding_protein_4	0,25	insulin	49,56	Retinol-binding protein 4	insulin	5950	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Retinol-binding_protein_4 is not associated with insulin resistance in pregnancy .
25627686	0	Retinol_Dehydrogenase	18,39	FoxO1	100,105	Retinol Dehydrogenase	FoxO1	131	2308	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Insulin Regulates Retinol_Dehydrogenase Expression and All-trans-retinoic_Acid Biosynthesis through FoxO1 .
25627686	0	Retinol_Dehydrogenase	18,39	Insulin	0,7	Retinol Dehydrogenase	Insulin	131	3630	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Insulin Regulates Retinol_Dehydrogenase Expression and All-trans-retinoic_Acid Biosynthesis through FoxO1 .
19597296	0	Retinol_binding_protein-4	0,25	TNF-alpha	45,54	Retinol binding protein-4	TNF-alpha	5950	7124	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	Retinol_binding_protein-4 is associated with TNF-alpha and not insulin resistance in subjects with type_2_diabetes_mellitus and coronary_heart_disease .
20677810	0	Retinoschisin	0,13	RS1	15,18	Retinoschisin	RS1	20147(Tax:10090)	20147(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|appos|END_ENTITY	Retinoschisin -LRB- RS1 -RRB- interacts with negatively charged lipid bilayers in the presence of Ca2 + : an atomic force microscopy study .
16240294	0	Rev	103,106	Rev	56,59	Rev	Rev	155908(Tax:11676)	155908(Tax:11676)	Gene	Gene	element|nmod|START_ENTITY element|compound|END_ENTITY	Quantitative analysis of shape-specific interactions of Rev response element with a positively charged Rev peptide by capillary electrophoresis .
16240294	0	Rev	56,59	Rev	103,106	Rev	Rev	155908(Tax:11676)	155908(Tax:11676)	Gene	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	Quantitative analysis of shape-specific interactions of Rev response element with a positively charged Rev peptide by capillary electrophoresis .
15777852	0	Rev	44,47	env	20,23	Rev	env	155908(Tax:11676)	155971(Tax:11676)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Regulation of HIV-1 env mRNA translation by Rev protein .
9150887	0	Rev	11,14	gag	43,46	Rev	gag	155908(Tax:11676)	155030(Tax:11676)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression .
20534529	0	Rev-erb_alpha	97,110	Arf-bp1	11,18	Rev-erb alpha	Arf-bp1	217166(Tax:10090)	59026(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb_alpha .
19682428	0	Rev-erb_beta	0,12	Srebp-1c	27,35	Rev-erb beta	Srebp-1c	353187(Tax:10090)	20787(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|promoter promoter|compound|END_ENTITY	Rev-erb_beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells .
17996965	0	Rev-erbbeta	28,39	Tip60	49,54	Rev-erbbeta	Tip60	9975	10524	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein_CIII promoter .
23747975	0	Rev1	74,78	PCNA	15,19	Rev1	PCNA	854527(Tax:4932)	852385(Tax:4932)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	NMR mapping of PCNA interaction with translesion_synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domain .
23761444	0	Rev1	80,84	PCNA	33,37	Rev1	PCNA	51455	5111	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|tolerance tolerance|acl|mediated mediated|nmod|fusions fusions|compound|END_ENTITY	DNA-damage tolerance mediated by PCNA * Ub fusions in human cells is dependent on Rev1 but not Pol .
23142547	0	Rev1	28,32	Rad5	121,125	Rev1	Rad5	854527(Tax:4932)	850719(Tax:4932)	Gene	Gene	function|nmod|START_ENTITY mediated|nsubjpass|function mediated|nmod|END_ENTITY	A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5 .
27001510	0	Rev1	97,101	Rad5	29,33	Rev1	Rad5	854527(Tax:4932)	850719(Tax:4932)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of budding yeast Rad5 in translesion_DNA_synthesis through physical interaction with Rev1 .
22024240	0	Rev1	39,43	dCMP	4,8	Rev1	dCMP	854527(Tax:4932)	248126	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites .
20890302	0	Reversion-inducing_cysteine-rich_protein_with_Kazal_motifs	0,58	epidermal_growth_factor_receptor	75,107	Reversion-inducing cysteine-rich protein with Kazal motifs	epidermal growth factor receptor	53614(Tax:10090)	13649(Tax:10090)	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	Reversion-inducing_cysteine-rich_protein_with_Kazal_motifs interferes with epidermal_growth_factor_receptor signaling .
23279369	0	Rex-1	30,35	IL-6	0,4	Rex-1	IL-6	57455	3569	Gene	Gene	expression|compound|START_ENTITY regulated|dobj|expression regulated|nsubj|END_ENTITY	IL-6 regulated stress-induced Rex-1 expression in stem cells from human exfoliated deciduous teeth .
20232320	0	Rex1	30,34	zfp42	36,41	Rex1	zfp42	132625	132625	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of Rex1 -LRB- zfp42 -RRB- in normal prostate epithelial cells and prostate_cancer cells .
11340166	0	Rfc4	0,4	Rpa1	20,24	Rfc4	Rpa1	854059(Tax:4932)	851266(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces_cerevisiae .
11850190	0	Rfpl4	36,41	ret_finger_protein-like_4	4,29	Rfpl4	ret finger protein-like 4	192658(Tax:10090)	192658(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The ret_finger_protein-like_4 gene , Rfpl4 , encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells .
22355072	0	Rfrp	97,101	RFamide-related_peptide	72,95	Rfrp	RFamide-related peptide	60531(Tax:10090)	60531(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Development , sex steroid regulation , and phenotypic characterization of RFamide-related_peptide -LRB- Rfrp -RRB- gene expression and RFamide receptors in the mouse hypothalamus .
22698283	0	Rfx	51,54	Fd3F	30,34	Rfx	Fd3F	41266(Tax:7227)	31336(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization .
26149990	0	Rg1	34,37	Toll-like_receptor_4	93,113	Rg1	Toll-like receptor 4	140491(Tax:10090)	21898(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of ginsenosides Rg1 and Re on LPS-induced sepsis by competitive binding to Toll-like_receptor_4 .
26149990	0	Rg1	34,37	Toll-like_receptor_4	93,113	Rg1	Toll-like receptor 4	140491(Tax:10090)	21898(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of ginsenosides Rg1 and Re on LPS-induced sepsis by competitive binding to Toll-like_receptor_4 .
10607721	0	Rh-associated_glycoprotein	22,48	RhAG	50,54	Rh-associated glycoprotein	RhAG	6005	6005	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Surface expression of Rh-associated_glycoprotein -LRB- RhAG -RRB- in nonerythroid COS-1 cells .
26482938	0	Rh2	18,21	histone_deacetylase	40,59	Rh2	histone deacetylase	6005	9734	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Ginsenoside_20 -LRB- s -RRB- - Rh2 as potent natural histone_deacetylase inhibitors suppressing the growth of human leukemia cells .
10607721	0	RhAG	50,54	Rh-associated_glycoprotein	22,48	RhAG	Rh-associated glycoprotein	6005	6005	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Surface expression of Rh-associated_glycoprotein -LRB- RhAG -RRB- in nonerythroid COS-1 cells .
6442022	0	RhO	111,114	rhesus-system_antigen_D	87,110	RhO	rhesus-system antigen D	6010	6010	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Ultrastructure and cytochemical indices of lymphocytes from donors immunized with the rhesus-system_antigen_D -LRB- RhO -RRB- -RSB- .
16803888	0	Rheb	0,4	C-raf	14,19	Rheb	C-raf	6009	5894	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization .
12820960	0	Rheb	22,26	Insulin	0,7	Rheb	Insulin	6009	3630	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Insulin activation of Rheb , a mediator of mTOR/S6K/4E-BP signaling , is inhibited by TSC1_and_2 .
21135540	0	Rheb	32,36	NR3A	68,72	Rheb	NR3A	19744(Tax:10090)	242443(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the small GTPase Rheb with the NMDA receptor subunit NR3A .
22649696	0	Rheb	37,41	Rabin8	0,6	Rheb	Rabin8	6009	117177	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	Rabin8 Protein Interacts with GTPase Rheb and Inhibits Phosphorylation of Ser235/Ser236 in Small Ribosomal Subunit Protein S6 .
18842593	0	Rheb	0,4	Rap1B	49,54	Rheb	Rap1B	6009	5908	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Rheb and mTOR regulate neuronal polarity through Rap1B .
12766775	0	Rheb	0,4	S6K	34,37	Rheb	S6K	117332(Tax:7227)	38654(Tax:7227)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Rheb is an essential regulator of S6K in controlling cell growth in Drosophila .
20127734	0	Rheb	76,80	androgen_receptor	14,31	Rheb	androgen receptor	6009	367	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of androgen_receptor transactivity and mTOR-S6 kinase pathway by Rheb in prostate_cancer cell proliferation .
12906785	0	Rheb	143,147	mTOR	72,76	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY acting|nmod|complex signaling|advcl|acting END_ENTITY|acl|signaling	Tuberous_sclerosis complex gene products , Tuberin and Hamartin , control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb .
14982927	0	Rheb	142,146	mTOR	179,183	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	homolog_enriched_in_brain|appos|START_ENTITY hypoxia-inducible_factor-1|nmod|homolog_enriched_in_brain mammalian_target_of_rapamycin|amod|hypoxia-inducible_factor-1 mammalian_target_of_rapamycin|appos|END_ENTITY	Follicle-stimulating hormone activation of hypoxia-inducible_factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras _ homolog_enriched_in_brain -LRB- Rheb -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway is necessary for induction of select protein markers of follicular differentiation .
15854902	0	Rheb	0,4	mTOR	29,33	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|kinase kinase|compound|END_ENTITY	Rheb binds and regulates the mTOR kinase .
15878852	0	Rheb	0,4	mTOR	47,51	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	binding|compound|START_ENTITY binding|appos|END_ENTITY	Rheb binding to mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by amino_acid sufficiency .
16728407	0	Rheb	102,106	mTOR	50,54	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	GTPase|compound|START_ENTITY mutant|nmod|GTPase signaling|nmod|mutant Hyperactivation|acl|signaling Hyperactivation|nmod|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	Hyperactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling by a gain-of-function mutant of the Rheb GTPase .
16757352	0	Rheb	0,4	mTOR	19,23	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	START_ENTITY|dobj|activation activation|nmod|signaling signaling|compound|END_ENTITY	Rheb activation of mTOR and S6K1 signaling .
17991864	0	Rheb	0,4	mTOR	15,19	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Rheb activates mTOR by antagonizing its endogenous inhibitor , FKBP38 .
18550814	0	Rheb	35,39	mTOR	47,51	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Phospholipase_D1 is an effector of Rheb in the mTOR pathway .
19451232	0	Rheb	104,108	mTOR	27,31	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate_dehydrogenase-mediated regulation of Rheb .
20837708	0	Rheb	79,83	mTOR	20,24	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY regulation|nmod|interaction controls|nmod|regulation controls|dobj|END_ENTITY	Cyclic_AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase_4D .
21067284	0	Rheb	153,157	mTOR	88,92	Rheb	mTOR	19744(Tax:10090)	21977(Tax:10090)	Gene	Gene	ubiquitination|nmod|START_ENTITY promoting|dobj|ubiquitination pathway|acl|promoting pathway|compound|END_ENTITY	Hydrogen_peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells .
24648513	0	Rheb	61,65	mTOR	147,151	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	glycine|nmod|START_ENTITY mutation|nmod|glycine generates|nsubj|mutation generates|dobj|regulator regulator|nmod|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|appos|END_ENTITY	Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
26782056	0	Rheb	82,86	mTOR	38,42	Rheb	mTOR	6009	21977(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY inhibition|nmod|degradation mediated|nmod|inhibition mediated|nsubjpass|action action|nmod|ketamine ketamine|nmod|END_ENTITY	Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation .
26234902	0	Rheb	0,4	mTORC1	34,40	Rheb	mTORC1	6009	382056(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|dep|END_ENTITY	Rheb signaling and tumorigenesis : mTORC1 and new horizons .
14982927	0	Rheb	142,146	mammalian_target_of_rapamycin	148,177	Rheb	mammalian target of rapamycin	6009	2475	Gene	Gene	homolog_enriched_in_brain|appos|START_ENTITY hypoxia-inducible_factor-1|nmod|homolog_enriched_in_brain END_ENTITY|amod|hypoxia-inducible_factor-1	Follicle-stimulating hormone activation of hypoxia-inducible_factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras _ homolog_enriched_in_brain -LRB- Rheb -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway is necessary for induction of select protein markers of follicular differentiation .
15809346	0	Rheb	31,35	mammalian_target_of_rapamycin	107,136	Rheb	mammalian target of rapamycin	6009	2475	Gene	Gene	role|nmod|START_ENTITY role|dep|implication implication|nmod|endocytic endocytic|nmod|activation activation|nmod|END_ENTITY	Novel role of the small GTPase Rheb : its implication in endocytic pathway independent of the activation of mammalian_target_of_rapamycin .
15878852	0	Rheb	0,4	mammalian_target_of_rapamycin	16,45	Rheb	mammalian target of rapamycin	6009	2475	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Rheb binding to mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by amino_acid sufficiency .
16728407	0	Rheb	102,106	mammalian_target_of_rapamycin	19,48	Rheb	mammalian target of rapamycin	6009	2475	Gene	Gene	GTPase|compound|START_ENTITY mutant|nmod|GTPase signaling|nmod|mutant Hyperactivation|acl|signaling Hyperactivation|nmod|END_ENTITY	Hyperactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling by a gain-of-function mutant of the Rheb GTPase .
17928295	0	Rheb	99,103	mammalian_target_of_rapamycin	49,78	Rheb	mammalian target of rapamycin	6009	2475	Gene	Gene	interacting|nmod|START_ENTITY mediates|advcl|interacting mediates|dobj|inhibition inhibition|nmod|END_ENTITY	Bnip3 mediates the hypoxia-induced inhibition on mammalian_target_of_rapamycin by interacting with Rheb .
24648513	0	Rheb	61,65	mammalian_target_of_rapamycin	116,145	Rheb	mammalian target of rapamycin	6009	2475	Gene	Gene	glycine|nmod|START_ENTITY mutation|nmod|glycine generates|nsubj|mutation generates|dobj|regulator regulator|nmod|END_ENTITY	Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
12842888	0	Rheb	0,4	tuberous_sclerosis_complex_2	11,39	Rheb	tuberous sclerosis complex 2	6009	7249	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Rheb binds tuberous_sclerosis_complex_2 -LRB- TSC2 -RRB- and promotes S6 kinase activation in a rapamycin - and farnesylation-dependent manner .
17942919	0	Rheb	118,122	tuberous_sclerosis_complex_2	34,62	Rheb	tuberous sclerosis complex 2	19744(Tax:10090)	22084(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|inhibition inhibition|nmod|growth growth|nmod|cells cells|amod|END_ENTITY	Selective inhibition of growth of tuberous_sclerosis_complex_2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity .
21238928	0	Rheb1	0,5	mTORC1	22,28	Rheb1	mTORC1	19744(Tax:10090)	382056(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Rheb1 is required for mTORC1 and myelination in postnatal brain development .
27071307	0	Rheb1	0,5	mTORC1	41,47	Rheb1	mTORC1	19744(Tax:10090)	382056(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute_myeloid_leukemia .
22683505	0	Rhes	27,31	AKT	42,45	Rhes	AKT	23551	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Striatum specific protein , Rhes regulates AKT pathway .
21541782	0	Rhg4	66,70	LRR-RLK	77,84	Rhg4	LRR-RLK	100286794(Tax:3847)	547710(Tax:3847)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Soybean cyst nematode resistance in soybean is independent of the Rhg4 locus LRR-RLK gene .
11278452	0	Rho	53,56	Galphaq	40,47	Rho	Galphaq	6010	2776	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Physical and functional interactions of Galphaq with Rho and its exchange factors .
12748065	0	Rho	30,33	MLC	84,87	Rho	MLC	6010	23209	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Hyperosmotic stress activates Rho : differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation .
12748065	0	Rho	63,66	MLC	84,87	Rho	MLC	6010	23209	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Hyperosmotic stress activates Rho : differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation .
22820501	0	Rho	13,16	R-cadherin	27,37	Rho	R-cadherin	6010	1002	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Small GTPase Rho regulates R-cadherin through Dia1/profilin -1 .
12748065	0	Rho	30,33	Rho	63,66	Rho	Rho	6010	6010	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Hyperosmotic stress activates Rho : differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation .
12748065	0	Rho	63,66	Rho	30,33	Rho	Rho	6010	6010	Gene	Gene	phosphorylation|compound|START_ENTITY involvement|nmod|phosphorylation END_ENTITY|dep|involvement	Hyperosmotic stress activates Rho : differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation .
16164598	0	Rho	0,3	epidermal_growth_factor_receptor	28,60	Rho	epidermal growth factor receptor	6010	1956	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|endocytosis endocytosis|nmod|END_ENTITY	Rho mediates endocytosis of epidermal_growth_factor_receptor through phosphorylation of endophilin A1 by Rho-kinase .
18331582	0	Rho	72,75	p250GAP	103,110	Rho	p250GAP	6010	9743	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein , p250GAP .
17369826	0	Rho	0,3	p38alpha	45,53	Rho	p38alpha	24717(Tax:10116)	81649(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death .
19151751	0	Rho-GAP	27,34	DLC1	22,26	Rho-GAP	DLC1	392	10395	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities .
19151751	0	Rho-GAP	27,34	p120Ras-GAP	0,11	Rho-GAP	p120Ras-GAP	392	5921	Gene	Gene	protein|compound|START_ENTITY binds|dobj|protein binds|nsubj|END_ENTITY	p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities .
18586382	0	Rho-kinase	15,25	interleukin-6	62,75	Rho-kinase	interleukin-6	19878(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Involvement of Rho-kinase in prostaglandin_F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts .
21750859	0	Rho-kinase	0,10	interleukin-6	41,54	Rho-kinase	interleukin-6	19878(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|amod|END_ENTITY	Rho-kinase regulates thrombin-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts .
11113201	0	Rho1	137,141	Rom2	90,94	Rho1	Rom2	856294(Tax:4932)	851086(Tax:4932)	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2 , a guanine_nucleotide exchange factor for Rho1 .
26179915	0	Rho1	0,4	Syp1	62,66	Rho1	Syp1	856294(Tax:4932)	850396(Tax:4932)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rho1 - and Pkc1-dependent phosphorylation of the F-BAR protein Syp1 contributes to septin ring assembly .
12135916	0	Rho1	0,4	p120ctn	20,27	Rho1	p120ctn	36775(Tax:7227)	3355143(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rho1 interacts with p120ctn and alpha-catenin , and regulates cadherin-based adherens junction components in Drosophila .
16207756	0	Rho1	0,4	p120ctn	62,69	Rho1	p120ctn	36775(Tax:7227)	3355143(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|ccomp|junctions junctions|nmod|END_ENTITY	Rho1 regulates Drosophila adherens junctions independently of p120ctn .
16514150	0	Rho3	4,8	Wsc1p	59,64	Rho3	Wsc1p	854688(Tax:4932)	854170(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The Rho3 and Rho4 small GTPases interact functionally with Wsc1p , a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces_cerevisiae .
21865595	0	RhoA	42,46	ARHGAP18	0,8	RhoA	ARHGAP18	387	93663	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	ARHGAP18 , a GTPase-activating protein for RhoA , controls cell shape , spreading , and motility .
21715309	0	RhoA	13,17	ARHGEF3	46,53	RhoA	ARHGEF3	100006041(Tax:7955)	570228(Tax:7955)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Silencing of RhoA nucleotide exchange factor , ARHGEF3 , reveals its unexpected role in iron uptake .
22243257	0	RhoA	65,69	Ameloblastin	0,12	RhoA	Ameloblastin	11848(Tax:10090)	11698(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Ameloblastin regulates cell attachment and proliferation through RhoA and p27 .
19692654	0	RhoA	23,27	Angiotensin_II	0,14	RhoA	Angiotensin II	387	183	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Angiotensin_II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells .
25903128	0	RhoA	70,74	Apolipoprotein_E	0,16	RhoA	Apolipoprotein E	387	348	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	Apolipoprotein_E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway .
15860730	0	RhoA	16,20	BCL6	0,4	RhoA	BCL6	387	604	Gene	Gene	activity|compound|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	BCL6 suppresses RhoA activity to alter macrophage morphology and motility .
19509057	0	RhoA	28,32	CD151	12,17	RhoA	CD151	387	977	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts .
25101858	0	RhoA	18,22	CD44	0,4	RhoA	CD44	387	960	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	CD44 acts through RhoA to regulate YAP signaling .
23405219	0	RhoA	15,19	CYLD	0,4	RhoA	CYLD	387	1540	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	CYLD regulates RhoA activity by modulating LARG ubiquitination .
16723500	0	RhoA	88,92	Cingulin	0,8	RhoA	Cingulin	403954(Tax:9615)	483198(Tax:9615)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA .
20585662	0	RhoA	49,53	Connective_tissue_growth_factor	0,31	RhoA	Connective tissue growth factor	11848(Tax:10090)	14219(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Connective_tissue_growth_factor in regulation of RhoA mediated cytoskeletal tension associated osteogenesis of mouse adipose-derived stromal cells .
20805359	0	RhoA	20,24	Cortactin	0,9	RhoA	Cortactin	387	2017	Gene	Gene	activation|compound|START_ENTITY modulates|dobj|activation modulates|nsubj|END_ENTITY	Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head_and_neck_squamous_cell_carcinoma cells .
16630611	0	RhoA	70,74	DAAM1	30,35	RhoA	DAAM1	11848(Tax:10090)	208846(Tax:10090)	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42 , CIP4 and Src in regulating cell morphogenesis and actin dynamics .
11062019	0	RhoA	14,18	Dbl	53,56	RhoA	Dbl	11848(Tax:10090)	109904(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of RhoA by association of Galpha -LRB- 13 -RRB- with Dbl .
22918940	0	RhoA	35,39	Diacylglycerol_kinase	0,21	RhoA	Diacylglycerol kinase	387	1607	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Diacylglycerol_kinase regulates RhoA activation via a kinase-independent scaffolding mechanism .
12777392	0	RhoA	47,51	ERK	117,120	RhoA	ERK	117273(Tax:10116)	24338(Tax:10116)	Gene	Gene	Initiation|nmod|START_ENTITY Initiation|dep|regulation regulation|nmod|translocation translocation|compound|END_ENTITY	Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae : cytoskeletal regulation of ERK translocation .
26816343	0	RhoA	34,38	ERK	42,45	RhoA	ERK	387	5594	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and Activation of RhoA by ERK in Response to Epidermal_Growth_Factor Stimulation .
24043311	0	RhoA	48,52	Extracellular_signal-regulated_kinase	0,37	RhoA	Extracellular signal-regulated kinase	387	5594	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine_exchange_factor_H1 activity .
26458995	0	RhoA	112,116	Fbxw7	0,5	RhoA	Fbxw7	387	55294	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Fbxw7 regulates tumor apoptosis , growth_arrest and the epithelial-to-mesenchymal transition in part through the RhoA signaling pathway in gastric_cancer .
24205360	0	RhoA	57,61	Filamin-A	0,9	RhoA	Filamin-A	11848(Tax:10090)	192176(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis .
22571463	0	RhoA	75,79	GCF2	25,29	RhoA	GCF2	387	9208	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA , regulating membrane protein trafficking , sensitivity to doxorubicin , and resistance to cisplatin .
17488622	0	RhoA	27,31	GEF-H1	0,6	RhoA	GEF-H1	387	9181	Gene	Gene	activation|compound|START_ENTITY modulates|dobj|activation modulates|nsubj|END_ENTITY	GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases .
15363038	0	RhoA	17,21	GM-CSF	0,6	RhoA	GM-CSF	387	1437	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	GM-CSF activates RhoA , integrin and MMP expression in human monocytic cells .
23176180	0	RhoA	57,61	Gonadotropin-releasing_hormone_receptor	0,39	RhoA	Gonadotropin-releasing hormone receptor	387	2798	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Gonadotropin-releasing_hormone_receptor activates GTPase RhoA and inhibits cell invasion in the breast_cancer cell line MDA-MB-231 .
21518791	0	RhoA	56,60	Hax1	0,4	RhoA	Hax1	387	10456	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Hax1 regulates neutrophil adhesion and motility through RhoA .
18996642	0	RhoA	102,106	Huh-7	110,115	RhoA	Huh-7	387	284424	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	A novel amplification target , ARHGAP5 , promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular_carcinoma cells .
23785489	0	RhoA	151,155	IL1RAPL1	0,8	RhoA	IL1RAPL1	387	11141	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	IL1RAPL1 associated with mental_retardation and autism regulates the formation and stabilization of glutamatergic synapses of cortical neurons through RhoA signaling pathway .
20363740	0	RhoA	50,54	IpgB2	22,27	RhoA	IpgB2	387	13917053	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structure of Shigella IpgB2 in complex with human RhoA : implications for the mechanism of bacterial guanine_nucleotide exchange factor mimicry .
24585879	0	RhoA	4,8	LARG	45,49	RhoA	LARG	387	23365	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	The RhoA guanine_nucleotide exchange factor , LARG , mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration .
14644158	0	RhoA	0,4	MMP-9	13,18	RhoA	MMP-9	387	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion .
20628524	0	RhoA	132,136	Matrix_Metalloproteinase-7	26,52	RhoA	Matrix Metalloproteinase-7	387	4316	Gene	Gene	Cleavage|nmod|START_ENTITY Cleavage|nmod|Proliferation Proliferation|compound|END_ENTITY	Cleavage of E-Cadherin by Matrix_Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA .
14729465	0	RhoA	46,50	MgcRacGAP	0,9	RhoA	MgcRacGAP	387	29127	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MgcRacGAP regulates cortical activity through RhoA during cytokinesis .
25947135	0	RhoA	27,31	MgcRacGAP	0,9	RhoA	MgcRacGAP	379416(Tax:8355)	431862(Tax:8355)	Gene	Gene	restricts|dobj|START_ENTITY restricts|nsubj|END_ENTITY	MgcRacGAP restricts active RhoA at the cytokinetic furrow and both RhoA and Rac1 at cell-cell junctions in epithelial cells .
26252513	0	RhoA	78,82	MgcRacGAP	29,38	RhoA	MgcRacGAP	387	29127	Gene	Gene	activation|compound|START_ENTITY promoting|dobj|activation non-canonically|advcl|promoting non-canonically|nsubj|functions functions|compound|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
26252513	0	RhoA	78,82	MgcRacGAP	29,38	RhoA	MgcRacGAP	387	29127	Gene	Gene	activation|compound|START_ENTITY promoting|dobj|activation non-canonically|advcl|promoting non-canonically|nsubj|functions functions|compound|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
19421144	0	RhoA	140,144	Myosin-interacting_guanine_exchange_factor	0,42	RhoA	Myosin-interacting guanine exchange factor	387	55200	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Myosin-interacting_guanine_exchange_factor -LRB- MyoGEF -RRB- regulates the invasion activity of MDA-MB-231 breast_cancer cells through activation of RhoA and RhoC .
15178452	0	RhoA	0,4	NF-kappaB	38,47	RhoA	NF-kappaB	387	4790	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|activation activation|amod|END_ENTITY	RhoA and Rac1 signals in fMLP-induced NF-kappaB activation in human blood monocytes .
19602845	0	RhoA	64,68	NF-kappaB	73,82	RhoA	NF-kappaB	387	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells .
25445826	0	RhoA	0,4	P2Y1_receptor	32,45	RhoA	P2Y1 receptor	11848(Tax:10090)	18441(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	RhoA signaling through platelet P2Y1_receptor controls leukocyte recruitment in allergic mice .
15530360	0	RhoA	25,29	PDZRhoGEF	68,77	RhoA	PDZRhoGEF	387	9826;9181	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF , an activator of the Ca -LRB- 2 + -RRB- sensitization pathway in smooth muscle .
15930143	0	RhoA	22,26	PKC-alpha	52,61	RhoA	PKC-alpha	387	5578	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of RhoA with specific domains of PKC-alpha .
23762244	0	RhoA	54,58	Par6C	70,75	RhoA	Par6C	387	50855	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis .
18343818	0	RhoA	111,115	Par6c	91,96	RhoA	Par6c	387	50855	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Transforming_growth_factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA .
17360533	0	RhoA	89,93	Polo-like_kinase_1	46,64	RhoA	Polo-like kinase 1	387	5347	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Chemical genetics reveals the requirement for Polo-like_kinase_1 activity in positioning RhoA and triggering cytokinesis in human cells .
17635521	0	RhoA	29,33	Polo-like_kinase_1	0,18	RhoA	Polo-like kinase 1	387	5347	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Polo-like_kinase_1 regulates RhoA during cytokinesis exit in human cells .
16481321	0	RhoA	53,57	Pragmin	0,7	RhoA	Pragmin	387	157285	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Pragmin , a novel effector of Rnd2 GTPase , stimulates RhoA activity .
22228765	0	RhoA	27,31	Protein_kinase_D	0,16	RhoA	Protein kinase D	387	5587	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Protein_kinase_D regulates RhoA activity via rhotekin phosphorylation .
22553010	0	RhoA	20,24	Pur-alpha	0,9	RhoA	Pur-alpha	11848(Tax:10090)	19290(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Pur-alpha regulates RhoA developmental expression and downstream signaling .
22430126	0	RhoA	55,59	ROCK1	0,5	RhoA	ROCK1	387	6093	Gene	Gene	regulation|nmod|START_ENTITY feedback|dobj|regulation feedback|nsubj|END_ENTITY	ROCK1 feedback regulation of the upstream small GTPase RhoA .
23828571	0	RhoA	0,4	ROCK1	59,64	RhoA	ROCK1	387	6093	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|interaction interaction|nmod|END_ENTITY	RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells .
25944062	0	RhoA	0,4	ROCK1	6,11	RhoA	ROCK1	387	6093	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	RhoA / ROCK1 regulates Avian_Reovirus S1133-induced switch from autophagy to apoptosis .
25944062	0	RhoA	0,4	ROCK1	6,11	RhoA	ROCK1	387	6093	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	RhoA / ROCK1 regulates Avian_Reovirus S1133-induced switch from autophagy to apoptosis .
11279039	0	RhoA	0,4	Rac1	46,50	RhoA	Rac1	117273(Tax:10116)	363875(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|factor-induced factor-induced|dobj|activation activation|amod|END_ENTITY	RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway .
15736231	0	RhoA	0,4	Rac1	18,22	RhoA	Rac1	117273(Tax:10116)	363875(Tax:10116)	Gene	Gene	Cdc42|compound|START_ENTITY Cdc42|appos|END_ENTITY	RhoA , RhoB , RhoC , Rac1 , Cdc42 , and Tc10 mRNA levels in spinal cord , sensory ganglia , and corticospinal tract neurons and long-lasting specific changes following spinal_cord_injury .
17300916	0	RhoA	93,97	Rac1	85,89	RhoA	Rac1	387	5879	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Regulator_of_G-protein_signalling_3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation .
20696841	0	RhoA	0,4	Rac1	29,33	RhoA	Rac1	117273(Tax:10116)	363875(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY induces|nsubj|phosphorylation induces|dobj|release release|amod|END_ENTITY	RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor alpha and stimulation of vascular smooth muscle cell migration .
25107911	0	RhoA	13,17	Rac1	115,119	RhoA	Rac1	387	5879	Gene	Gene	Contributes|nsubj|START_ENTITY Contributes|xcomp|IL-1b IL-1b|nmod|Stimulation Stimulation|nmod|Activity Activity|amod|END_ENTITY	Unprenylated RhoA Contributes to IL-1b Hypersecretion in Mevalonate_Kinase Deficiency Model through Stimulation of Rac1 Activity .
9546375	0	RhoA	25,29	RhoA	70,74	RhoA	RhoA	117273(Tax:10116)	117273(Tax:10116)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Angiotensin_II activates RhoA in cardiac myocytes : a critical role of RhoA in angiotensin_II-induced premyofibril formation .
9546375	0	RhoA	70,74	RhoA	25,29	RhoA	RhoA	117273(Tax:10116)	117273(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Angiotensin_II activates RhoA in cardiac myocytes : a critical role of RhoA in angiotensin_II-induced premyofibril formation .
15736231	0	RhoA	0,4	RhoB	6,10	RhoA	RhoB	117273(Tax:10116)	64373(Tax:10116)	Gene	Gene	Cdc42|compound|START_ENTITY Cdc42|appos|END_ENTITY	RhoA , RhoB , RhoC , Rac1 , Cdc42 , and Tc10 mRNA levels in spinal cord , sensory ganglia , and corticospinal tract neurons and long-lasting specific changes following spinal_cord_injury .
15736231	0	RhoA	0,4	RhoC	12,16	RhoA	RhoC	117273(Tax:10116)	295342(Tax:10116)	Gene	Gene	Cdc42|compound|START_ENTITY Cdc42|appos|END_ENTITY	RhoA , RhoB , RhoC , Rac1 , Cdc42 , and Tc10 mRNA levels in spinal cord , sensory ganglia , and corticospinal tract neurons and long-lasting specific changes following spinal_cord_injury .
7600583	0	RhoA	23,27	SRF	86,89	RhoA	SRF	387	6722	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	The Rho family GTPases RhoA , Rac1 , and CDC42Hs regulate transcriptional activation by SRF .
21421853	0	RhoA	108,112	SWAP-70	92,99	RhoA	SWAP-70	11848(Tax:10090)	20947(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Sphingosine_1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA .
12200418	0	RhoA	61,65	Serum_response_factor	0,21	RhoA	Serum response factor	387	6722	Gene	Gene	receptors|nmod|START_ENTITY activation|nmod|receptors activation|nsubj|END_ENTITY	Serum_response_factor activation by muscarinic receptors via RhoA .
11114521	0	RhoA	49,53	Shp-2	33,38	RhoA	Shp-2	387	5781	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The protein tyrosine phosphatase Shp-2 regulates RhoA activity .
12890560	0	RhoA	49,53	Smooth_muscle_gamma-actin	0,25	RhoA	Smooth muscle gamma-actin	395442(Tax:9031)	396084(Tax:9031)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Smooth_muscle_gamma-actin promoter regulation by RhoA and serum_response_factor signaling .
19470758	0	RhoA	69,73	Sox9	32,36	RhoA	Sox9	387	6662	Gene	Gene	signaling|compound|START_ENTITY regulated|nmod|signaling regulated|nsubjpass|activity activity|nmod|END_ENTITY	The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization .
15703273	0	RhoA	0,4	T-cadherin	77,87	RhoA	T-cadherin	387	1012	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	RhoA and Rac mediate endothelial cell polarization and detachment induced by T-cadherin .
26225425	0	RhoA	74,78	TGF-b2	32,38	RhoA	TGF-b2	387	7042	Gene	Gene	Cells|nmod|START_ENTITY END_ENTITY|nmod|Cells	All-Trans_Retinoic_Acid Induces TGF-b2 in Intestinal Epithelial Cells via RhoA - and p38a MAPK-Mediated Activation of the Transcription Factor ATF2 .
19755150	0	RhoA	53,57	UNC5a	92,97	RhoA	UNC5a	11848(Tax:10090)	107448(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nsubj|activation	Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth .
16019189	0	RhoA	0,4	Wnt5	24,28	RhoA	Wnt5	100006041(Tax:7955)	30105(Tax:7955)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous : use of zebrafish as an in vivo model for GTPase signaling .
12221096	0	RhoA	47,51	XPLN	0,4	RhoA	XPLN	387	50650	Gene	Gene	factor|nmod|START_ENTITY END_ENTITY|appos|factor	XPLN , a guanine_nucleotide exchange factor for RhoA and RhoB , but not RhoC .
21173159	0	RhoA	98,102	angiotensin_II	113,127	RhoA	angiotensin II	387	183	Gene	Gene	START_ENTITY|nmod|type type|amod|END_ENTITY	b-Arrestin_1 inhibits the GTPase-activating protein function of ARHGAP21 , promoting activation of RhoA following angiotensin_II type 1A receptor stimulation .
11342655	0	RhoA	52,56	beta_2	22,28	RhoA	beta 2	387	10242	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Role of p190RhoGAP in beta_2 integrin regulation of RhoA in human neutrophils .
9351440	0	RhoA	10,14	c-fos	26,31	RhoA	c-fos	387	2353	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Activated RhoA stimulates c-fos gene expression in myocardial cells .
15068801	0	RhoA	30,34	c-jun	45,50	RhoA	c-jun	387	3725	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis .
16723500	0	RhoA	88,92	claudin-2	19,28	RhoA	claudin-2	403954(Tax:9615)	403649(Tax:9615)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA .
22002306	0	RhoA	94,98	hPTTG1	14,20	RhoA	hPTTG1	387	9232	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Overexpressed hPTTG1 promotes breast_cancer cell invasion and metastasis by regulating GEF-H1 / RhoA signalling .
20859068	0	RhoA	13,17	interleukin-4	37,50	RhoA	interleukin-4	387	3565	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of RhoA gene expression by interleukin-4 in cultured human bronchial smooth muscle cells .
25043657	0	RhoA	26,30	mTOR	0,4	RhoA	mTOR	387	21977(Tax:10090)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	mTOR regulate EMT through RhoA and Rac1 pathway in prostate_cancer .
23836527	0	RhoA	55,59	mTORC2	36,42	RhoA	mTORC2	387	74343(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|xcomp|regulate	Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells .
21186079	0	RhoA	16,20	miR-185	0,7	RhoA	miR-185	387	406961	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells .
19798549	0	RhoA	14,18	osteopontin	48,59	RhoA	osteopontin	387	6696	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|dobj|expression expression|compound|END_ENTITY	Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts .
20974127	0	RhoA	152,156	p120	81,85	RhoA	p120	387	1500	Gene	Gene	mechanism|compound|START_ENTITY kinases|nmod|mechanism induced|nmod|kinases phosphorylation|acl|induced phosphorylation|amod|END_ENTITY	Ga -LRB- 12 -RRB- binds to the N-terminal regulatory domain of p120 -LRB- ctn -RRB- , and downregulates p120 -LRB- ctn -RRB- tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism .
24995336	0	RhoA	62,66	p120	0,4	RhoA	p120	387	1500	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	p120 modulates LPS-induced NF-kB activation partially through RhoA in bronchial epithelial cells .
10980705	0	RhoA	14,18	p120_catenin	22,34	RhoA	p120 catenin	387	1500	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of RhoA by p120_catenin .
9707430	0	RhoA	18,22	p160ROCK	0,8	RhoA	p160ROCK	387	6093	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	p160ROCK mediates RhoA activation of Na-H exchange .
11342655	0	RhoA	52,56	p190RhoGAP	8,18	RhoA	p190RhoGAP	387	2909	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of p190RhoGAP in beta_2 integrin regulation of RhoA in human neutrophils .
11553710	0	RhoA	0,4	p190RhoGAP	21,31	RhoA	p190RhoGAP	387	2909	Gene	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity .
16331259	0	RhoA	89,93	p50RhoGAP	62,71	RhoA	p50RhoGAP	387	392	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	BNIP-Salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain .
15322077	0	RhoA	0,4	phospholipase_C-epsilon	24,47	RhoA	phospholipase C-epsilon	387	5334	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	RhoA activates purified phospholipase_C-epsilon by a guanine_nucleotide-dependent mechanism .
10037681	0	RhoA	35,39	phospholipase_D1	69,85	RhoA	phospholipase D1	387	5337	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the small G protein RhoA with the C terminus of human phospholipase_D1 .
15150446	0	RhoA	79,83	phospholipase_D1	19,35	RhoA	phospholipase D1	387	5337	Gene	Gene	interaction|nmod|START_ENTITY Phosphorylation|nmod|interaction Phosphorylation|nmod|END_ENTITY	Phosphorylation of phospholipase_D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase .
16772297	0	RhoA	29,33	protein_kinase_D	83,99	RhoA	protein kinase D	11848(Tax:10090)	18760(Tax:10090)	Gene	Gene	GTPase|compound|START_ENTITY requirement|nmod|GTPase Differential|dobj|requirement Differential|advcl|localization localization|nmod|END_ENTITY	Differential requirement for RhoA GTPase depending on the cellular localization of protein_kinase_D .
12039949	0	RhoA	111,115	serum_response_factor	17,38	RhoA	serum response factor	11848(Tax:10090)	20807(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulated|nmod|signaling regulated|nsubjpass|activity activity|nmod|END_ENTITY	High activity of serum_response_factor in the mesenchymal transition of epithelial_tumor cells is regulated by RhoA signaling .
9804789	0	RhoA	0,4	serum_response_factor	19,40	RhoA	serum response factor	11848(Tax:10090)	20807(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	RhoA signaling via serum_response_factor plays an obligatory role in myogenic differentiation .
15963030	0	RhoA	11,15	utrophin	26,34	RhoA	utrophin	11848(Tax:10090)	22288(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	The GTPase RhoA increases utrophin expression and stability , as well as its localization at the plasma membrane .
19409875	0	RhoA	0,4	utrophin	50,58	RhoA	utrophin	11848(Tax:10090)	22288(Tax:10090)	Gene	Gene	leads|nsubj|START_ENTITY leads|nmod|up-regulation up-regulation|nmod|END_ENTITY	RhoA leads to up-regulation and relocalization of utrophin in muscle fibers .
11350930	0	RhoA-associated_kinase-2	67,91	transglutaminase_II	8,27	RhoA-associated kinase-2	transglutaminase II	9475	7051	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of transglutaminase_II in retinoic_acid-induced activation of RhoA-associated_kinase-2 .
11058585	0	RhoA-specific_guanine_nucleotide_exchange_factor	34,82	p190RhoGEF	20,30	RhoA-specific guanine nucleotide exchange factor	p190RhoGEF	9826	64283;9181	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of p190RhoGEF , a RhoA-specific_guanine_nucleotide_exchange_factor that interacts with microtubules .
15548709	0	RhoB	34,38	Cyclin_B1	0,9	RhoB	Cyclin B1	11852(Tax:10090)	268697(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cyclin_B1 is a critical target of RhoB in the cell suicide program triggered by farnesyl transferase inhibition .
26759237	0	RhoB	147,151	GEF-H1	140,146	RhoB	GEF-H1	388	9181	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small_Cell_Lung_Cancer Cells by Inhibiting YAP Activation through the GEF-H1 / RhoB Pathway .
13679859	0	RhoB	49,53	Histone_deacetylase_1	0,21	RhoB	Histone deacetylase 1	388	3065	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Histone_deacetylase_1 represses the small GTPase RhoB expression in human nonsmall_lung_carcinoma cell line .
17728102	0	RhoB	43,47	NF-kappaB	30,39	RhoB	NF-kappaB	388	4790	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	ROCK_I-mediated activation of NF-kappaB by RhoB .
15736231	0	RhoB	6,10	RhoA	0,4	RhoB	RhoA	64373(Tax:10116)	117273(Tax:10116)	Gene	Gene	Cdc42|appos|START_ENTITY Cdc42|compound|END_ENTITY	RhoA , RhoB , RhoC , Rac1 , Cdc42 , and Tc10 mRNA levels in spinal cord , sensory ganglia , and corticospinal tract neurons and long-lasting specific changes following spinal_cord_injury .
23430146	0	RhoB	56,60	Rnd3	0,4	RhoB	Rnd3	388	390	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Rnd3 induces stress fibres in endothelial cells through RhoB .
19637314	0	RhoB	0,4	TNFAIP1	51,58	RhoB	TNFAIP1	388	7126	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells .
24086429	0	RhoB	17,21	TNFa	32,36	RhoB	TNFa	388	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The small GTPase RhoB regulates TNFa signaling in endothelial cells .
21084431	0	RhoB	16,20	c-Jun_N-terminal_kinase	25,48	RhoB	c-Jun N-terminal kinase	388	5599	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Upregulation of RhoB via c-Jun_N-terminal_kinase signaling induces apoptosis of the human gastric_carcinoma NUGC-3 cells treated with NSC12618 .
16278215	0	RhoB	0,4	epidermal_growth_factor_receptor	69,101	RhoB	epidermal growth factor receptor	388	1956	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal_growth_factor_receptor signaling .
21872591	0	RhoB	36,40	miR-21	0,6	RhoB	miR-21	388	406991	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-21 targets the tumor suppressor RhoB and regulates proliferation , invasion and apoptosis in colorectal_cancer cells .
24636898	0	RhoB	75,79	p300	0,4	RhoB	p300	388	2033	Gene	Gene	site|nmod|START_ENTITY c-Jun|nmod|site cooperates|nmod|c-Jun cooperates|amod|END_ENTITY	p300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis .
24636898	0	RhoB	75,79	p300	45,49	RhoB	p300	388	2033	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	p300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis .
23258531	0	RhoBTB1	26,33	miR-31	55,61	RhoBTB1	miR-31	9886	407035	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon_cancer .
18039672	0	RhoBTB2	0,7	E2F1	28,32	RhoBTB2	E2F1	23221	1869	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	RhoBTB2 -LRB- DBC2 -RRB- is a mitotic E2F1 target gene with a novel role in apoptosis .
21732343	0	RhoC	6,10	ETS-1	0,5	RhoC	ETS-1	389	2113	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|appos|regulates	ETS-1 / RhoC signaling regulates the transcription factor c-Jun in melanoma .
19701800	0	RhoC	46,50	LNX	0,3	RhoC	LNX	389	84708	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LNX -LRB- Ligand of Numb-protein X -RRB- interacts with RhoC , both of which regulate AP-1-mediated transcriptional activation .
19953094	0	RhoC	48,52	Notch1	0,6	RhoC	Notch1	389	4851	Gene	Gene	contribution|nmod|START_ENTITY regulates|dobj|contribution regulates|nsubj|END_ENTITY	Notch1 regulates the functional contribution of RhoC to cervical_carcinoma progression .
23382905	0	RhoC	36,40	Ras_homologous_C	18,34	RhoC	Ras homologous C	11853(Tax:10090)	11853(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Ras_homologous_C -LRB- RhoC -RRB- induces malignant_transformation_of_hepatocytes in vitro and in nude mouse xenografts .
15736231	0	RhoC	12,16	RhoA	0,4	RhoC	RhoA	295342(Tax:10116)	117273(Tax:10116)	Gene	Gene	Cdc42|appos|START_ENTITY Cdc42|compound|END_ENTITY	RhoA , RhoB , RhoC , Rac1 , Cdc42 , and Tc10 mRNA levels in spinal cord , sensory ganglia , and corticospinal tract neurons and long-lasting specific changes following spinal_cord_injury .
25516960	0	RhoC	0,4	RhoGDI2	32,39	RhoC	RhoGDI2	389	397	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder_Cancer .
20735965	0	RhoC	15,19	RhoGDIgamma	50,61	RhoC	RhoGDIgamma	389	398	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dep|Expression	-LSB- Expression of RhoC and its regulators RhoGDIbeta RhoGDIgamma and their clinical importance in lung squamous_cell_cancer and adenocarcinoma . -RSB- .
26622610	0	RhoC	0,4	TGF-b1	21,27	RhoC	TGF-b1	389	7040	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	RhoC is essential in TGF-b1 induced epithelial-mesenchymal transition in cervical cancer cells .
16511001	0	RhoC	62,66	mDia1	40,45	RhoC	mDia1	389	13367(Tax:10090)	Gene	Gene	purification|nmod|START_ENTITY purification|nmod|END_ENTITY	The purification and crystallization of mDia1 in complex with RhoC .
24102721	0	RhoD	0,4	Rabankyrin-5	29,41	RhoD	Rabankyrin-5	29984	51479	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor .
17027967	0	RhoG	22,26	Dock4	0,5	RhoG	Dock4	391	9732	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Dock4 is regulated by RhoG and promotes Rac-dependent cell migration .
21621533	0	RhoG	57,61	Ephexin4	0,8	RhoG	Ephexin4	391	27237	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol_3-kinase .
24659802	0	RhoG	26,30	P-Rex1	0,6	RhoG	P-Rex1	56212(Tax:10090)	277360(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils .
12376551	0	RhoG	0,4	Rac1	30,34	RhoG	Rac1	391	5879	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	RhoG signals in parallel with Rac1 and Cdc42 .
12879077	0	RhoG	0,4	Rac1	15,19	RhoG	Rac1	391	5879	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo .
9614181	0	RhoG	0,4	Rac1	60,64	RhoG	Rac1	308875(Tax:10116)	363875(Tax:10116)	Gene	Gene	GTPase|compound|START_ENTITY controls|nsubj|GTPase controls|dobj|pathway pathway|acl:relcl|activates activates|dobj|END_ENTITY	RhoG GTPase controls a pathway that independently activates Rac1 and Cdc42Hs .
11967128	0	RhoG	19,23	RhoGDI-3	0,8	RhoG	RhoGDI-3	391	398	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain .
26252513	0	RhoGAP	4,10	CYK-4	23,28	RhoGAP	CYK-4	392	29127	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
26252513	0	RhoGAP	4,10	CYK-4	23,28	RhoGAP	CYK-4	392	29127	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The RhoGAP activity of CYK-4 / MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis .
16024604	0	RhoGAP	4,10	DLC-1	19,24	RhoGAP	DLC-1	75404(Tax:10090)	50768(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nsubj|protein	The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast_cancer cells .
18505793	0	RhoGAP	6,12	MT1-MMP	71,78	RhoGAP	MT1-MMP	392	4323	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2 .
12932438	0	RhoGAP	4,10	OPHN1	23,28	RhoGAP	OPHN1	392	4983	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The RhoGAP activity of OPHN1 , a new F-actin-binding protein , is negatively controlled by its amino-terminal domain .
21185940	0	RhoGAP	4,10	Porf-2	38,44	RhoGAP	Porf-2	75404(Tax:10090)	223666(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The RhoGAP domain-containing protein , Porf-2 , inhibits proliferation and enhances apoptosis in neural stem cells .
15234003	0	RhoGAP	45,51	RARhoGAP	18,26	RhoGAP	RARhoGAP	58834(Tax:10116)	367085(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Identification of RARhoGAP , a novel putative RhoGAP gene expressed in male germ cells .
17664338	0	RhoGAP	35,41	SHP2	89,93	RhoGAP	SHP2	392	5781	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The neurite outgrowth multiadaptor RhoGAP , NOMA-GAP , regulates neurite extension through SHP2 and Cdc42 .
24466350	0	RhoGAP	4,10	myosin_IXB	23,33	RhoGAP	myosin IXB	392	4650	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The RhoGAP activity of myosin_IXB is critical for osteoclast podosome patterning , motility , and resorptive capacity .
17314409	0	RhoGAP	53,59	myosin_IXb	42,52	RhoGAP	myosin IXb	392	4650	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	The Myosin_IXb motor activity targets the myosin_IXb RhoGAP domain as cargo to sites of actin polymerization .
12788081	0	RhoGAP	18,24	p250GAP	0,7	RhoGAP	p250GAP	392	9743	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	p250GAP , a neural RhoGAP protein , is associated with and phosphorylated by Fyn .
23776598	0	RhoGDI	25,31	PKCa	52,56	RhoGDI	PKCa	396	5578	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cholecystokinin-mediated RhoGDI phosphorylation via PKCa promotes both RhoA and Rac1 signaling .
16472651	0	RhoGDI	19,25	p21-activated_kinase_1	29,51	RhoGDI	p21-activated kinase 1	396	5058	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of RhoGDI by p21-activated_kinase_1 .
11967128	0	RhoGDI-3	0,8	RhoG	19,23	RhoGDI-3	RhoG	398	391	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain .
16878152	0	RhoGDI2	55,62	Neuromedin_U	0,12	RhoGDI2	Neuromedin U	397	10874	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Neuromedin_U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation , lung metastasis and cancer_cachexia .
25901126	0	RhoGDI2	0,7	P-glycoprotein	21,35	RhoGDI2	P-glycoprotein	397	5243	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric_cancer cells .
22469974	0	RhoGDI2	24,31	PKCa	0,4	RhoGDI2	PKCa	397	5578	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	PKCa phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity .
25901126	0	RhoGDI2	0,7	Rac1	51,55	RhoGDI2	Rac1	397	5879	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	RhoGDI2 up-regulates P-glycoprotein expression via Rac1 in gastric_cancer cells .
25516960	0	RhoGDI2	32,39	RhoC	0,4	RhoGDI2	RhoC	397	389	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder_Cancer .
22777355	0	RhoGDI2	47,54	Rictor	0,6	RhoGDI2	Rictor	397	253260	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Rictor regulates cell migration by suppressing RhoGDI2 .
23354413	0	RhoGDI2	18,25	Rictor	0,6	RhoGDI2	Rictor	397	253260	Gene	Gene	encounters|dobj|START_ENTITY encounters|nsubj|END_ENTITY	Rictor encounters RhoGDI2 : the second pilot is taking a lead .
19321744	0	RhoGDI2	23,30	Src	0,3	RhoGDI2	Src	397	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function .
25253431	0	RhoGDI2	0,7	VEGF	63,67	RhoGDI2	VEGF	397	7422	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach_cancer .
26707877	0	RhoGDI2	46,53	filamin_A	31,40	RhoGDI2	filamin A	397	2316	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	An adventitious interaction of filamin_A with RhoGDI2 -LRB- Tyr153Glu -RRB- .
20735965	0	RhoGDIgamma	50,61	RhoC	15,19	RhoGDIgamma	RhoC	398	389	Gene	Gene	START_ENTITY|dep|Expression Expression|nmod|END_ENTITY	-LSB- Expression of RhoC and its regulators RhoGDIbeta RhoGDIgamma and their clinical importance in lung squamous_cell_cancer and adenocarcinoma . -RSB- .
18445682	0	RhoGEF	66,72	BNIP2	0,5	RhoGEF	BNIP2	9826	663	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain .
24386507	0	RhoGEF	25,31	Ect2	12,16	RhoGEF	Ect2	64283	1894	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	The Role of Ect2 Nuclear RhoGEF Activity in Ovarian_Cancer_Cell_Transformation .
20738848	0	RhoH	26,30	IL3	41,44	RhoH	IL3	399	3562	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression .
21103055	0	RhoH	0,4	ZAP-70	43,49	RhoH	ZAP-70	399	7535	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling .
20547754	0	RhoU	49,53	Src	102,105	RhoU	Src	58480	6714	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Regulation of the Rho family small GTPase Wrch-1 / RhoU by C-terminal tyrosine phosphorylation requires Src .
18834107	0	Rho_kinase	107,117	ROCK-II	119,126	Rho kinase	ROCK-II	9475	9475	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of substituted 4 - -LRB- pyrazol-4-yl -RRB- - phenylbenzodioxane-2-carboxamides as potent and highly selective Rho_kinase -LRB- ROCK-II -RRB- inhibitors .
15146061	0	Rho_kinase	0,10	rho	85,88	Rho kinase	rho	19878(Tax:10090)	212541(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	Rho_kinase regulates the intracellular micromechanical response of adherent cells to rho activation .
12062050	0	Rho_kinase_2	10,22	Wnt11	42,47	Rho kinase 2	Wnt11	321070(Tax:7955)	791595(Tax:7955)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Zebrafish Rho_kinase_2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements .
26083914	0	Rhodopsin	16,25	Flip	8,12	Rhodopsin	Flip	6010	8837	Gene	Gene	Activation|compound|START_ENTITY END_ENTITY|nmod|Activation	Retinal Flip in Rhodopsin Activation ?
19289571	0	Ribophorin_I	87,99	mu-Opioid_receptor	0,18	Ribophorin I	mu-Opioid receptor	6184	4988	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	mu-Opioid_receptor cell surface expression is regulated by its direct interaction with Ribophorin_I .
25945329	0	Ribosomal_Protein_S1_Gene	18,43	rpsA	45,49	Ribosomal Protein S1 Gene	rpsA	5964809(Tax:561007)	5964809(Tax:561007)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of the Ribosomal_Protein_S1_Gene -LRB- rpsA -RRB- as a Novel Biomarker for Mycobacterium Species Identification .
25945329	0	Ribosomal_Protein_S1_Gene	18,43	rpsA	45,49	Ribosomal Protein S1 Gene	rpsA	5964809(Tax:561007)	5964809(Tax:561007)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of the Ribosomal_Protein_S1_Gene -LRB- rpsA -RRB- as a Novel Biomarker for Mycobacterium Species Identification .
26527685	0	Ribosomal_S6_Kinase_1	20,41	RSK1	43,47	Ribosomal S6 Kinase 1	RSK1	6195	6195	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Structural basis of Ribosomal_S6_Kinase_1 -LRB- RSK1 -RRB- inhibition by S100B Protein : modulation of the Extracellular_Signal-regulated_Kinase -LRB- ERK -RRB- signaling cascade in a calcium-dependent way .
10469565	0	Ribosomal_S6_kinase_1	0,21	RSK1	23,27	Ribosomal S6 kinase 1	RSK1	6195	6195	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Ribosomal_S6_kinase_1 -LRB- RSK1 -RRB- activation requires signals dependent on and independent of the MAP kinase ERK .
17647292	0	Ribosomal_protein_S17	0,21	RPS17	28,33	Ribosomal protein S17	RPS17	6218	6218	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ribosomal_protein_S17 gene -LRB- RPS17 -RRB- is mutated in Diamond-Blackfan_anemia .
19155217	0	Ribosomal_protein_S19	0,21	macrophage_migration_inhibitory_factor	37,75	Ribosomal protein S19	macrophage migration inhibitory factor	6223	4282	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ribosomal_protein_S19 interacts with macrophage_migration_inhibitory_factor and attenuates its pro-inflammatory function .
15473865	0	Ribosomal_protein_S2	0,20	PRMT3	50,55	Ribosomal protein S2	PRMT3	6187	10196	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Ribosomal_protein_S2 is a substrate for mammalian PRMT3 -LRB- protein_arginine_methyltransferase_3 -RRB- .
25144937	0	Ribosomal_protein_S27-like	0,26	p53	59,62	Ribosomal protein S27-like	p53	67941(Tax:10090)	22059(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Ribosomal_protein_S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis .
24457201	0	Ribosomal_protein_S3	0,20	IkBa	56,60	Ribosomal protein S3	IkBa	6188	4792	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ribosomal_protein_S3 interacts with the NF-kB inhibitor IkBa .
22510408	0	Ribosomal_protein_S3	0,20	TRADD	36,41	Ribosomal protein S3	TRADD	6188	8717	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ribosomal_protein_S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation .
23131551	0	Ribosomal_protein_S3	0,20	microtubule_associated_protein	73,103	Ribosomal protein S3	microtubule associated protein	6188	51115	Gene	Gene	localizes|nsubj|START_ENTITY localizes|nmod|END_ENTITY	Ribosomal_protein_S3 localizes on the mitotic spindle and functions as a microtubule_associated_protein in mitosis .
23563151	0	Ribosomal_protein_S7	0,20	GADD45a	48,55	Ribosomal protein S7	GADD45a	6201	1647	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Ribosomal_protein_S7 regulates arsenite-induced GADD45a expression by attenuating MDM2-mediated GADD45a ubiquitination and degradation .
23563151	0	Ribosomal_protein_S7	0,20	GADD45a	96,103	Ribosomal protein S7	GADD45a	6201	1647	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|attenuating attenuating|dobj|ubiquitination ubiquitination|amod|END_ENTITY	Ribosomal_protein_S7 regulates arsenite-induced GADD45a expression by attenuating MDM2-mediated GADD45a ubiquitination and degradation .
12509430	0	Ric-8A	10,16	Galpha	49,55	Ric-8A	Galpha	60626	8802	Gene	Gene	factor|nsubj|START_ENTITY factor|compound|END_ENTITY	Mammalian Ric-8A -LRB- synembryn -RRB- is a heterotrimeric Galpha protein guanine_nucleotide exchange factor .
25074811	0	Ric8a	28,33	NCS-1	59,64	Ric8a	NCS-1	60626	23413	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The guanine-exchange factor Ric8a binds the calcium sensor NCS-1 to regulate synapse number and probability of release .
21557327	0	Rictor	0,6	MMP-9	17,22	Rictor	MMP-9	253260	4318	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells .
26176550	0	Rictor	87,93	Mammalian_Target_of_Rapamycin	39,68	Rictor	Mammalian Target of Rapamycin	253260	2475	Gene	Gene	Protein|compound|START_ENTITY Protein|compound|END_ENTITY	Defining the Domain Arrangement of the Mammalian_Target_of_Rapamycin Complex Component Rictor Protein .
20978191	0	Rictor	23,29	PKCzeta	45,52	Rictor	PKCzeta	253260	5590	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis .
22777355	0	Rictor	0,6	RhoGDI2	47,54	Rictor	RhoGDI2	253260	397	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Rictor regulates cell migration by suppressing RhoGDI2 .
23354413	0	Rictor	0,6	RhoGDI2	18,25	Rictor	RhoGDI2	253260	397	Gene	Gene	encounters|nsubj|START_ENTITY encounters|dobj|END_ENTITY	Rictor encounters RhoGDI2 : the second pilot is taking a lead .
19720745	0	Rictor	20,26	S6K1	96,100	Rictor	S6K1	253260	6198	Gene	Gene	sites|compound|START_ENTITY Characterization|nmod|sites reveals|nsubj|Characterization reveals|xcomp|complex complex|nmod|END_ENTITY	Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1 .
19995915	0	Rictor	37,43	S6K1	17,21	Rictor	S6K1	253260	6198	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling .
20978191	0	Rictor	23,29	mTOR	0,4	Rictor	mTOR	253260	21977(Tax:10090)	Gene	Gene	START_ENTITY|amod|complex complex|amod|END_ENTITY	mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis .
9347917	0	Rieg	29,33	Brx1	23,27	Rieg	Brx1	18741(Tax:10090)	18741(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Expression patterns of Brx1 -LRB- Rieg gene -RRB- , Sonic_hedgehog , Nkx2 .2 , Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation .
15668168	0	Rif	22,25	mDia2	52,57	Rif	mDia2	54509	56419(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	The Rho family GTPase Rif induces filopodia through mDia2 .
24685139	0	Rif1	0,4	Glc7	74,78	Rif1	Glc7	852578(Tax:4932)	856870(Tax:4932)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7 .
11278839	0	Rim1	49,53	Rab3a	0,5	Rim1	Rab3a	22999	5864	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique .
9372955	0	Rim11p	95,101	Ume6p	49,54	Rim11p	Ume6p	855170(Tax:4932)	851788(Tax:4932)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of yeast repressor-activator protein Ume6p with glycogen_synthase_kinase_3 homolog Rim11p .
21957239	0	Rin	38,41	dopamine_transporter	61,81	Rin	dopamine transporter	6014	6531	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The plasma membrane-associated GTPase Rin interacts with the dopamine_transporter and is required for protein kinase C-regulated dopamine_transporter trafficking .
17403676	0	Rin1	0,4	signal-transducing_adaptor_molecule	20,55	Rin1	signal-transducing adaptor molecule	9610	8027	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rin1 interacts with signal-transducing_adaptor_molecule -LRB- STAM -RRB- and mediates epidermal_growth_factor_receptor trafficking and degradation .
24497168	0	Ring1B	0,6	Cdkn1a	91,97	Ring1B	Cdkn1a	19821(Tax:10090)	12575(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice .
24903147	0	Ring1B	15,21	Snail	0,5	Ring1B	Snail	6045	6615	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic_cancer cells .
20676133	0	Ring_finger_protein_11	64,86	RNF11	88,93	Ring finger protein 11	RNF11	26994	26994	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Multiple modification and protein interaction signals drive the Ring_finger_protein_11 -LRB- RNF11 -RRB- E3 ligase to the endosomal compartment .
26980022	0	Ring_finger_protein_43	0,22	RNF43	24,29	Ring finger protein 43	RNF43	54894	54894	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ring_finger_protein_43 -LRB- RNF43 -RRB- expression is associated with genetic_alteration status and poor prognosis among patients with intrahepatic_cholangiocarcinoma .
21081503	0	RioK1	0,5	pICln	87,92	RioK1	pICln	83732	1207	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	RioK1 , a new interactor of protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- , competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity .
18030616	0	Rip1	26,30	PTHrP	10,15	Rip1	PTHrP	8737	5744	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Midregion PTHrP regulates Rip1 and caspase expression in MDA-MB231 breast_cancer cells .
15175328	0	Rip1	23,27	Traf2	165,170	Rip1	Traf2	19766(Tax:10090)	22030(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY required|nsubjpass|activity required|nmod|END_ENTITY	The kinase activity of Rip1 is not required for tumor_necrosis_factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2 .
22237751	0	Rip1	0,4	receptor-interacting_protein_kinase_1	6,43	Rip1	receptor-interacting protein kinase 1	19766(Tax:10090)	19766(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|dep|END_ENTITY	Rip1 -LRB- receptor-interacting_protein_kinase_1 -RRB- mediates necroptosis and contributes to renal_ischemia / reperfusion injury .
26515129	0	Rip11	17,22	Insulin	0,7	Rip11	Insulin	26056	3630	Gene	Gene	accumulation|amod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin - and PI3-kinase-dependent , but Akt-independent , internalisation event .
25751141	0	Rip3	65,69	Ppm1b	0,5	Rip3	Ppm1b	56532(Tax:10090)	19043(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 .
18603780	0	Ris1p	140,145	Ebp2p	29,34	Ris1p	Ebp2p	854363(Tax:4932)	853682(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	SUMO mediates interaction of Ebp2p , the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2 , with a RING finger protein Ris1p .
26876013	0	Rlbp1	80,85	Microphthalmia-associated_transcription_factor	0,46	Rlbp1	Microphthalmia-associated transcription factor	19771(Tax:10090)	17342(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Microphthalmia-associated_transcription_factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal_pigment_epithelium .
26687416	0	Rlf	56,59	Ral	96,99	Rlf	Ral	6018	5898	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	The structure of the Guanine Nucleotide Exchange Factor Rlf in complex with the small G-protein Ral identifies conformational intermediates of the exchange reaction and the basis for the selectivity .
23185031	0	Rlp24	0,5	Drg1	31,35	Rlp24	Drg1	51187	4733	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Rlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturation .
15051737	0	Rme-8	21,26	Hsc70	42,47	Rme-8	Hsc70	35939(Tax:7227)	39542(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila .
17448464	0	Rmt2	31,35	Nup49	103,108	Rmt2	Nup49	852076(Tax:4932)	852703(Tax:4932)	Gene	Gene	enriched|nsubjpass|START_ENTITY enriched|nmod|END_ENTITY	The arginine methyltransferase Rmt2 is enriched in the nucleus and co-purifies with the nuclear porins Nup49 , Nup57 and Nup100 .
3924907	0	RnBP	34,38	renin_binding_protein	11,32	RnBP	renin binding protein	5973	5973	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A study on renin_binding_protein -LRB- RnBP -RRB- in the human kidney .
9199303	0	Rna15	26,31	Pab1	6,10	Rna15	Pab1	5157776(Tax:316278)	856912(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Yeast Pab1 interacts with Rna15 and participates in the control of the poly -LRB- A -RRB- tail length in vitro .
12730235	0	Rnd1	22,26	Plexin-B1	90,99	Rnd1	Plexin-B1	27289	5364	Gene	Gene	interaction|nmod|START_ENTITY regulates|nsubj|interaction regulates|nmod|END_ENTITY	Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells .
12590651	0	Rnd2	18,22	MgcRacGAP	55,64	Rnd2	MgcRacGAP	8153	29127	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells .
18045987	0	Rnd3	20,24	B-RAF	0,5	Rnd3	B-RAF	390	673	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization .
23430146	0	Rnd3	0,4	RhoB	56,60	Rnd3	RhoB	390	388	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Rnd3 induces stress fibres in endothelial cells through RhoB .
20811643	0	Rnd3	32,36	Syx	13,16	Rnd3	Syx	74194(Tax:10090)	269608(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain .
10822263	0	Rnf4	0,4	Gscl	98,102	Rnf4	Gscl	19822(Tax:10090)	195333(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rnf4 , a RING protein expressed in the developing nervous and reproductive systems , interacts with Gscl , a gene within the DiGeorge critical region .
16204183	0	Rnf6	21,25	LIM_kinase_1	42,54	Rnf6	LIM kinase 1	74132(Tax:10090)	16885(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	The ubiquitin ligase Rnf6 regulates local LIM_kinase_1 levels in axonal growth cones .
22101936	0	Rnf8	24,28	Tpp1	40,44	Rnf8	Tpp1	9025	1200	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection .
1911778	0	Ro/SS-A	58,65	calreticulin	75,87	Ro/SS-A	calreticulin	6737	811	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen -LRB- calreticulin -RRB- with a highly conserved amino_acid sequence in the cytoplasmic domain of integrin alpha subunits .
24768604	1	Ro52	62,66	SS-B/La	105,112	Ro52	SS-B/La	6737	6741	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	The detection of Ro52 and Ro60 according to the presence of SS-B/La , and ANA pattern and titer .
17565045	0	Robo-1	7,13	Slit-2	0,6	Robo-1	Slit-2	6091	9353	Gene	Gene	modulates|nsubj|START_ENTITY END_ENTITY|parataxis|modulates	Slit-2 / Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells .
17968499	0	Robo1	58,63	Slit2	0,5	Robo1	Slit2	6091	9353	Gene	Gene	receptor|amod|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|involvement involvement|amod|END_ENTITY	Slit2 involvement in glioma cell migration is mediated by Robo1 receptor .
22826604	0	Robo1	14,19	Slit2	56,61	Robo1	Slit2	6091	9353	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Activation of Robo1 signaling of breast_cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/b-catenin pathway .
25894826	0	Robo1	24,29	Slit2	0,5	Robo1	Slit2	19876(Tax:10090)	20563(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Slit2 signaling through Robo1 and Robo2 is required for retinal_neovascularization .
23525682	0	Robo2	58,63	Mycbp2	24,30	Robo2	Mycbp2	268902(Tax:10090)	105689(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The E3 ubiquitin ligase Mycbp2 genetically interacts with Robo2 to modulate axon guidance in the mouse olfactory system .
21211783	0	Robo4	0,5	CXCR4	22,27	Robo4	CXCR4	54538	7852	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches .
20498081	0	Robo4	9,14	VEGF	39,43	Robo4	VEGF	54538	7422	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|END_ENTITY	Vascular Robo4 restricts proangiogenic VEGF signaling in breast .
16480767	0	Rock-1	72,78	caveolin-1	96,106	Rock-1	caveolin-1	6093	857	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	Caveolin-1 and lipid rafts in confluent BeWo trophoblasts : evidence for Rock-1 association with caveolin-1 .
20661774	0	Rock-2	90,96	caspase-2	50,59	Rock-2	caspase-2	9475	835	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Ouabain-induced apoptosis and Rho kinase : a novel caspase-2 cleavage site and fragment of Rock-2 .
22705122	0	Rock2	0,5	Cdc25A	16,22	Rock2	Cdc25A	9475	993	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Rock2 regulates Cdc25A through ubiquitin proteasome system in hepatocellular_carcinoma cells .
26505794	0	Rock2	0,5	b-catenin	17,26	Rock2	b-catenin	9475	1499	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	Rock2 stabilizes b-catenin to promote tumor invasion and metastasis in colorectal_cancer .
21551065	0	Roco2	30,35	Rab1A	52,57	Roco2	Rab1A	120892	5861	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton .
9879655	0	Rod_outer_segment_membrane_guanylate_cyclase_type_1	0,51	ROS-GC1	53,60	Rod outer segment membrane guanylate cyclase type 1	ROS-GC1	3000	3000	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rod_outer_segment_membrane_guanylate_cyclase_type_1 -LRB- ROS-GC1 -RRB- gene : structure , organization and regulation by phorbol_ester , a protein_kinase_C activator .
24553290	0	Rok	55,58	Knittrig	33,41	Rok	Knittrig	43916(Tax:7227)	39004(Tax:7227)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The Drosophila FHOD1-like formin Knittrig acts through Rok to promote stress fiber formation and directed macrophage migration during the cellular immune response .
21097620	0	Rok	0,3	yuaB	14,18	Rok	yuaB	938793(Tax:224308)	938831(Tax:224308)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Rok regulates yuaB expression during architecturally complex colony development of Bacillus_subtilis 168 .
11113201	0	Rom2	90,94	Rho1	137,141	Rom2	Rho1	851086(Tax:4932)	856294(Tax:4932)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Wsc1 and Mid2 are cell surface sensors for cell wall integrity signaling that act through Rom2 , a guanine_nucleotide exchange factor for Rho1 .
25824963	0	Romo-1	58,64	reactive_oxygen_species_modulator_1	21,56	Romo-1	reactive oxygen species modulator 1	140823	140823	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The rs6060566 of the reactive_oxygen_species_modulator_1 -LRB- Romo-1 -RRB- gene affects Romo-1 expression and the development of diabetic_retinopathy in Caucasians with type 2 diabetes .
21558421	0	Romo1	0,5	Myc	42,45	Romo1	Myc	140823	4609	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Romo1 is a negative-feedback regulator of Myc .
20434834	0	Ron	39,42	receptor_tyrosine_kinase	43,67	Ron	receptor tyrosine kinase	19882(Tax:10090)	22174(Tax:10090)	Gene	Gene	synergy|nmod|START_ENTITY Acts|nmod|synergy END_ENTITY|nsubj|Acts	Chk2 * 1100delC Acts in synergy with the Ron receptor_tyrosine_kinase to accelerate mammary tumorigenesis in mice .
20689759	0	Ron	0,3	receptor_tyrosine_kinase	4,28	Ron	receptor tyrosine kinase	4486	5979	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Ron receptor_tyrosine_kinase activation confers resistance to tamoxifen in breast_cancer cell lines .
24739671	0	Ron	22,25	receptor_tyrosine_kinase	26,50	Ron	receptor tyrosine kinase	4486	5979	Gene	Gene	Autoinhibition|nmod|START_ENTITY END_ENTITY|nsubj|Autoinhibition	Autoinhibition of the Ron receptor_tyrosine_kinase by the juxtamembrane domain .
10591629	0	Ropporin	0,8	rhophilin	46,55	Ropporin	rhophilin	76378(Tax:10090)	14787(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Ropporin , a sperm-specific binding protein of rhophilin , that is localized in the fibrous_sheath of sperm_flagella .
23893409	0	Ror2	49,53	Receptor_tyrosine_kinase-like_orphan_receptor_2	0,47	Ror2	Receptor tyrosine kinase-like orphan receptor 2	4920	4920	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Receptor_tyrosine_kinase-like_orphan_receptor_2 -LRB- Ror2 -RRB- expression creates a poised state of Wnt signaling in renal_cancer .
26840931	0	Ror2	29,33	Wnt5a-Ror1	18,28	Ror2	Wnt5a-Ror1	26564(Tax:10090)	22411(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	Essential role of Wnt5a-Ror1 / Ror2 signaling in metanephric mesenchyme and ureteric bud formation .
19785987	0	Ror2	72,76	Wtip	23,27	Ror2	Wtip	4920	126374	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling .
11468292	0	RotundRacGAP	34,46	Drac1	63,68	RotundRacGAP	Drac1	117503(Tax:7227)	38146(Tax:7227)	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	The Rac GTPase-activating protein RotundRacGAP interferes with Drac1 and Dcdc42 signalling in Drosophila_melanogaster .
20410118	0	Roundabout	38,48	neurexin_IV	11,22	Roundabout	neurexin IV	37603(Tax:7227)	39387(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Drosophila neurexin_IV interacts with Roundabout and is required for repulsive midline axon guidance .
8467707	0	Rowett_nude	24,35	RONU	42,46	Rowett nude	RONU	287469(Tax:10116)	287469(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regional mapping of the Rowett_nude gene -LRB- RONU -RRB- to rat chromosome 10q24 -- > q32 by localizing linked SYB2 and GH loci .
11960024	0	Rp1	159,162	retinitis_pigmentosa-1	135,157	Rp1	retinitis pigmentosa-1	19888(Tax:10090)	19888(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Progressive photoreceptor_degeneration , outer_segment_dysplasia , and rhodopsin mislocalization in mice with targeted disruption of the retinitis_pigmentosa-1 -LRB- Rp1 -RRB- gene .
11340166	0	Rpa1	20,24	Rfc4	0,4	Rpa1	Rfc4	851266(Tax:4932)	854059(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces_cerevisiae .
16314571	0	Rpb1	139,143	Set2	64,68	Rpb1	Set2	5430	29072	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1 .
25639305	0	Rpb6	107,111	RNA_polymerase_II-associated_protein_2	6,44	Rpb6	RNA polymerase II-associated protein 2	5435	79871	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human RNA_polymerase_II-associated_protein_2 -LRB- RPAP2 -RRB- interacts directly with the RNA polymerase II subunit Rpb6 and participates in pre-mRNA 3 _ - end formation .
9512514	0	Rpd3	32,36	Histone_deacetylase	0,19	Rpd3	Histone deacetylase	855386(Tax:4932)	855987(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Histone_deacetylase activity of Rpd3 is important for transcriptional repression in vivo .
25793372	0	Rpd3	27,31	Hmt1	98,102	Rpd3	Hmt1	3065	56052	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Correction : Recruitment of Rpd3 to the Telomere Depends on the Protein Arginine Methyltransferase Hmt1 .
21715356	0	Rpe65	84,89	Mef2c	47,52	Rpe65	Mef2c	19892(Tax:10090)	17260(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Altered expression of the transcription factor Mef2c during retinal_degeneration in Rpe65 - / - mice .
19050768	0	Rpe65	69,74	neuroglycan_C	13,26	Rpe65	neuroglycan C	19892(Tax:10090)	29873(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Differential neuroglycan_C expression during retinal_degeneration in Rpe65 - / - mice .
10488093	0	Rpg1p	196,201	eIF3	219,223	Rpg1p	eIF3	852371(Tax:4932)	8661	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The Saccharomyces_cerevisiae HCR1 gene encoding a homologue of the p35 subunit of human translation initiation factor 3 -LRB- eIF3 -RRB- is a high copy suppressor of a temperature-sensitive mutation in the Rpg1p subunit of yeast eIF3 .
15126390	0	Rpl3p	60,65	Dbp6p	26,31	Rpl3p	Dbp6p	854229(Tax:4932)	855774(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The putative RNA helicase Dbp6p functionally interacts with Rpl3p , Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces_cerevisiae .
26327385	0	Rpl8	86,90	NO66	48,52	Rpl8	NO66	6132	79697	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubj|Structure Structure|nmod|END_ENTITY	Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8 .
11071286	0	Rpn1	37,41	non-ATPase_subunit_1	65,85	Rpn1	non-ATPase subunit 1	856422(Tax:4932)	856422(Tax:4932)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cloning and functional expression of Rpn1 , a regulatory-particle non-ATPase_subunit_1 , of proteasome from Trypanosoma_cruzi .
19026775	0	Rpn10	0,5	Dsk2	35,39	Rpn10	Dsk2	5710	29978	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Rpn10 protects the proteasome from Dsk2 .
24292889	0	Rpn10	141,146	Ube3a	0,5	Rpn10	Ube3a	40388(Tax:7227)	39266(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Ube3a , the E3 ubiquitin ligase causing Angelman_syndrome and linked to autism , regulates protein homeostasis through the proteasomal shuttle Rpn10 .
27053109	0	Rpn8	23,27	Pih1	71,75	Rpn8	Pih1	854435(Tax:4932)	856429(Tax:4932)	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	The Proteasome Subunit Rpn8 Interacts with the snoRNP Assembly Protein Pih1 and Mediates its Ubiquitin-Independent Degradation in Saccharomyces_cerevisiae .
11880648	0	RpoV	48,52	WhiB3	27,32	RpoV	WhiB3	887477(Tax:83332)	887598(Tax:83332)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mycobacterium_tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth .
14715275	0	Rpp20	0,5	SMN	21,24	Rpp20	SMN	3772007(Tax:7227)	252667	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress .
22570489	0	Rps3	36,40	Yar1	0,4	Rps3	Yar1	855543(Tax:4932)	855837(Tax:4932)	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Yar1 protects the ribosomal protein Rps3 from aggregation .
21087929	0	Rrm3	73,77	Tof1	37,41	Rrm3	Tof1	856426(Tax:4932)	855448(Tax:4932)	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces_cerevisiae .
11265758	0	Rrn3p	116,121	TIF-IA	0,6	Rrn3p	TIF-IA	853734(Tax:4932)	54700	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	TIF-IA , the factor mediating growth-dependent control of ribosomal RNA synthesis , is the mammalian homolog of yeast Rrn3p .
7530050	0	Rrp1	56,60	nuclease	24,32	Rrp1	nuclease	33500(Tax:7227)	5656958	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Characterization of the nuclease activity of Drosophila Rrp1 on phosphoglycolate - and phosphate-modified DNA 3 ' - termini .
25775092	0	Rrp6	88,92	Nrd1	108,112	Rrp6	Nrd1	5394	4898	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Nab3 facilitates the function of the TRAMP complex in RNA processing via recruitment of Rrp6 independent of Nrd1 .
21131837	0	Rsf-1	0,5	HBXAP	7,12	Rsf-1	HBXAP	51773	51773	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Rsf-1 -LRB- HBXAP -RRB- expression is associated with advanced stage and lymph node metastasis in ovarian_clear_cell_carcinoma .
23378270	0	Rsf-1	0,5	cyclin_E1	55,64	Rsf-1	cyclin E1	308839(Tax:10116)	25729(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rsf-1 , a chromatin remodelling protein , interacts with cyclin_E1 and promotes tumour development .
11432835	0	Rsk2	0,4	estrogen_receptor_alpha	30,53	Rsk2	estrogen receptor alpha	6197	2099	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Rsk2 allosterically activates estrogen_receptor_alpha by docking to the hormone-binding_domain .
14988731	0	Rsp5	32,36	Bsd2	0,4	Rsp5	Bsd2	856862(Tax:4932)	852593(Tax:4932)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins .
18250098	0	Rspo1	40,45	beta-catenin	14,26	Rspo1	beta-catenin	284654	1499	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary .
24058607	0	Rsu-1	47,52	PINCH	8,13	Rsu-1	PINCH	20163(Tax:10090)	110829(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of PINCH and its partner tumor suppressor Rsu-1 in regulating liver size and tumorigenesis .
20385599	0	Rta	91,94	MCAF1	0,5	Rta	MCAF1	116535	55729	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	MCAF1 and synergistic activation of the transcription of Epstein-Barr_virus lytic genes by Rta and Zta .
23326574	0	Rta	46,49	TAF4	8,12	Rta	TAF4	116535	6874	Gene	Gene	activation|nmod|START_ENTITY Role|nmod|activation Role|nmod|END_ENTITY	Role of TAF4 in transcriptional activation by Rta of Epstein-Barr_Virus .
17301127	0	Rta	43,46	decoy_receptor_3	59,75	Rta	decoy receptor 3	116535	8771	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Epstein-Barr_virus transcription activator Rta upregulates decoy_receptor_3 expression by binding to its promoter .
12176919	0	Rta	0,3	interleukin-6	88,101	Rta	interleukin-6	4961526(Tax:37296)	3569	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Rta of the human_herpesvirus_8 / Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression .
12455997	0	Rub1p	0,5	Yuh1p	20,25	Rub1p	Yuh1p	851717(Tax:4932)	853562(Tax:4932)	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Rub1p processing by Yuh1p is required for wild-type levels of Rub1p conjugation to Cdc53p .
10645722	0	Rubisco_activase	0,16	rca	29,32	Rubisco activase	rca	5717936(Tax:3055)	5717936(Tax:3055)	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Rubisco_activase transcript -LRB- rca -RRB- abundance increases when the marine unicellular green alga Chlorococcum littorale is grown under high-CO2 stress .
25264196	0	RunX2	41,46	MiR-30a	0,7	RunX2	MiR-30a	860	407029	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-30a inhibits osteolysis by targeting RunX2 in giant_cell_tumor_of_bone .
25504218	0	Runt-Related_Transcription_Factor_2	108,143	Bone_Sialoprotein	43,60	Runt-Related Transcription Factor 2	Bone Sialoprotein	860	3381	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Oxidized Low-Density Lipoprotein Increases Bone_Sialoprotein Expression in Vascular Smooth Muscle Cells Via Runt-Related_Transcription_Factor_2 .
23148227	0	Runt-related_transcription_factor_1	0,35	p53	72,75	Runt-related transcription factor 1	p53	861	7157	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|protein protein|compound|END_ENTITY	Runt-related_transcription_factor_1 -LRB- RUNX1 -RRB- stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation .
19342459	0	Runt-related_transcription_factor_1	0,35	prostaglandin-endoperoxide_synthase_2	73,110	Runt-related transcription factor 1	prostaglandin-endoperoxide synthase 2	50662(Tax:10116)	29527(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Runt-related_transcription_factor_1 regulates luteinized hormone-induced prostaglandin-endoperoxide_synthase_2 expression in rat periovulatory granulosa cells .
15474477	0	Runx-2	0,6	RANKL	66,71	Runx-2	RANKL	12393(Tax:10090)	21943(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|expression expression|nmod|END_ENTITY	Runx-2 is not essential for the vitamin_D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells .
15361869	0	Runx1	36,41	Early_B_cell_factor	0,19	Runx1	Early B cell factor	861	1879	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Early_B_cell_factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription .
24646888	0	Runx1	39,44	Ets1	20,24	Runx1	Ets1	861	2113	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|basis basis|nmod|END_ENTITY	Structural basis of Ets1 activation by Runx1 .
19494111	0	Runx1	0,5	FOXO3	29,34	Runx1	FOXO3	12394(Tax:10090)	56484(Tax:10090)	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta -LRB- TGFbeta -RRB- - induced Bim transcription in hepatic cells .
22411870	0	Runx1	45,50	Polycomb_group_ring_finger_1	0,28	Runx1	Polycomb group ring finger 1	861	84759	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Polycomb_group_ring_finger_1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells .
15928041	0	Runx1	15,20	fetal_liver_kinase-1	47,67	Runx1	fetal liver kinase-1	12394(Tax:10090)	16542(Tax:10090)	Gene	Gene	START_ENTITY|nmod|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	Involvement of Runx1 in the down-regulation of fetal_liver_kinase-1 expression during transition of endothelial cells to hematopoietic cells .
19389811	0	Runx2	14,19	AR	42,44	Runx2	AR	12393(Tax:10090)	11835(Tax:10090)	Gene	Gene	START_ENTITY|nmod|androgen_receptor androgen_receptor|appos|END_ENTITY	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
19389811	0	Runx2	14,19	AR	88,90	Runx2	AR	12393(Tax:10090)	11835(Tax:10090)	Gene	Gene	Repression|nmod|START_ENTITY Repression|parataxis|binds binds|nsubj|END_ENTITY	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
19389811	0	Runx2	97,102	AR	42,44	Runx2	AR	12393(Tax:10090)	11835(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY Repression|parataxis|binds Repression|nmod|Runx2 Runx2|nmod|androgen_receptor androgen_receptor|appos|END_ENTITY	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
19389811	0	Runx2	97,102	AR	88,90	Runx2	AR	12393(Tax:10090)	11835(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Repression of Runx2 by androgen_receptor -LRB- AR -RRB- in osteoblasts and prostate_cancer cells : AR binds Runx2 and abrogates its recruitment to DNA .
12753866	0	Runx2	113,118	BMP-2	47,52	Runx2	BMP-2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY promotes|advcl|expressing promotes|nsubj|Transplantation Transplantation|nmod|fibroblasts fibroblasts|acl|expressing expressing|dobj|END_ENTITY	Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2 .
26455827	0	Runx2	107,112	BMP-2	88,93	Runx2	BMP-2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Smad/p38/JNK|dep|Pathway MC3T3-E1|parataxis|Smad/p38/JNK MC3T3-E1|dep|Proliferation Proliferation|nmod|END_ENTITY	Sambucus Williamsii Hance Promotes MC3T3-E1 Cells Proliferation and Differentiation via BMP-2 / Smad/p38/JNK / Runx2 Signaling Pathway .
16927309	0	Runx2	95,100	BMP2	70,74	Runx2	BMP2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	functional|advmod|START_ENTITY domain|amod|functional signaling|nmod|domain END_ENTITY|acl|signaling	Reconstitution of Runx2/Cbfa1-null cells identifies a requirement for BMP2 signaling through a Runx2 functional domain during osteoblast differentiation .
17060321	0	Runx2	65,70	BMP2	0,4	Runx2	BMP2	860	650	Gene	Gene	activation|nmod|START_ENTITY involves|dobj|activation involves|nsubj|commitment commitment|nummod|END_ENTITY	BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network .
22247071	0	Runx2	115,120	BMP2	87,91	Runx2	BMP2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	c-Jun_N-terminal_kinase_1 negatively regulates osteoblastic differentiation induced by BMP2 via phosphorylation of Runx2 at Ser104 .
15765505	0	Runx2	0,5	Bmp2	29,33	Runx2	Bmp2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development .
23983792	0	Runx2	209,214	Bone_Morphogenetic_Protein-2	165,193	Runx2	Bone Morphogenetic Protein-2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Aconiti Lateralis Preparata Radix Activates the Proliferation of Mouse Bone Marrow Mesenchymal Stem Cells and Induces Osteogenic Lineage Differentiation through the Bone_Morphogenetic_Protein-2 / Smad-Dependent Runx2 Pathway .
16613856	0	Runx2	40,45	Bone_morphogenetic_protein-2	0,28	Runx2	Bone morphogenetic protein-2	860	650	Gene	Gene	acetylation|amod|START_ENTITY stimulates|dobj|acetylation stimulates|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 stimulates Runx2 acetylation .
17215250	0	Runx2	107,112	Bone_morphogenetic_protein_2	0,28	Runx2	Bone morphogenetic protein 2	860	650	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Bone_morphogenetic_protein_2 activates Smad6 gene transcription through bone-specific transcription factor Runx2 .
18381576	0	Runx2	34,39	Cbfa-1	27,33	Runx2	Cbfa-1	860	860	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of Cbfa-1 / Runx2 in thyroid_papillary_carcinoma cells .
12434156	0	Runx2	23,28	Cbfbeta	0,7	Runx2	Cbfbeta	12393(Tax:10090)	12400(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cbfbeta interacts with Runx2 and has a critical role in bone development .
12434152	0	Runx2	40,45	Core-binding_factor_beta	0,24	Runx2	Core-binding factor beta	12393(Tax:10090)	12400(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Core-binding_factor_beta interacts with Runx2 and is required for skeletal development .
12459268	0	Runx2	145,150	Dlx5	108,112	Runx2	Dlx5	860	1749	Gene	Gene	distalless5|appos|START_ENTITY distalless5|appos|END_ENTITY	An L1 element disrupts human bone_sialoprotein promoter : lack of tissue-specific regulation by distalless5 -LRB- Dlx5 -RRB- and runt_homeodomain_protein2 -LRB- Runx2 -RRB- / core_binding_factor_a1 -LRB- Cbfa1 -RRB- elements .
12815054	0	Runx2	14,19	Dlx5	46,50	Runx2	Dlx5	12393(Tax:10090)	13395(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|nmod|END_ENTITY	BMP-2-induced Runx2 expression is mediated by Dlx5 , and TGF-beta_1 opposes the BMP-2-induced osteoblast differentiation by suppression of Dlx5 expression .
16115867	0	Runx2	104,109	Dlx5	0,4	Runx2	Dlx5	860	1749	Gene	Gene	distal|amod|START_ENTITY elements|nmod|distal binding|nmod|elements promoter|amod|binding expression|nmod|promoter regulates|dobj|expression regulates|nsubj|END_ENTITY	Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter .
16115867	0	Runx2	28,33	Dlx5	0,4	Runx2	Dlx5	860	1749	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Dlx5 specifically regulates Runx2 type II expression by binding to homeodomain-response elements in the Runx2 distal promoter .
17335796	0	Runx2	12,17	Dlx5	0,4	Runx2	Dlx5	373919(Tax:9031)	373969(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY drives|dobj|expression drives|nsubj|END_ENTITY	Dlx5 drives Runx2 expression and osteogenic differentiation in developing cranial suture mesenchyme .
26542806	0	Runx2	86,91	E3_Ubiquitin_Ligase	0,19	Runx2	E3 Ubiquitin Ligase	860	158506	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	E3_Ubiquitin_Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation .
21505104	0	Runx2	15,20	FOXO1	0,5	Runx2	FOXO1	860	2308	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	FOXO1 inhibits Runx2 transcriptional activity and prostate_cancer cell migration and invasion .
26390980	0	Runx2	87,92	Factor_b	13,21	Runx2	Factor b	12393(Tax:10090)	14962(Tax:10090)	Gene	Gene	Stabilization|nmod|START_ENTITY END_ENTITY|nmod|Stabilization	Core Binding Factor_b of Osteoblasts Maintains Cortical Bone Mass Via Stabilization of Runx2 in Mice .
26542806	0	Runx2	86,91	Fbw7	20,24	Runx2	Fbw7	860	55294	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	E3_Ubiquitin_Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation .
19903460	0	Runx2	72,77	Fibroblast_growth_factor-2	0,26	Runx2	Fibroblast growth factor-2	860	2247	Gene	Gene	activation|amod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Fibroblast_growth_factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells .
22389001	0	Runx2	34,39	G9a	27,30	Runx2	G9a	860	10919	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription .
26729095	0	Runx2	88,93	GM3_Synthase	32,44	Runx2	GM3 Synthase	860	8869	Gene	Gene	Mediated|nmod|START_ENTITY Mediated|nsubjpass|END_ENTITY	Serum Deprivation-Induced Human GM3_Synthase -LRB- hST3Gal_V -RRB- Gene Expression Is Mediated by Runx2 in Human Osteoblastic MG-63 Cells .
16442859	0	Runx2	0,5	GNAS	34,38	Runx2	GNAS	860	2778	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Runx2 regulates the expression of GNAS on SaOs-2 cells .
19160422	0	Runx2	84,89	Ghrelin	0,7	Runx2	Ghrelin	12393(Tax:10090)	58991(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY suppressing|dobj|expression inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	Ghrelin inhibits early osteogenic differentiation of C3H10T1/2 cells by suppressing Runx2 expression and enhancing PPARgamma and C/EBPalpha expression .
18162173	0	Runx2	44,49	Hes1	0,4	Runx2	Hes1	860	3280	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation .
17997710	0	Runx2	38,43	Histone_deacetylase_7	0,21	Runx2	Histone deacetylase 7	12393(Tax:10090)	56233(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Histone_deacetylase_7 associates with Runx2 and represses its activity during osteoblast maturation in a deacetylation-independent manner .
23326237	0	Runx2	47,52	MAML1	0,5	Runx2	MAML1	12393(Tax:10090)	103806(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development .
16549373	0	Runx2	146,151	MMP-1	44,49	Runx2	MMP-1	860	4312	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells : potential role of Runx2 in mediating p38 effects .
19422937	0	Runx2	27,32	MMP-13	16,22	Runx2	MMP-13	860	4322	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of MMP-13 via Runx2 in the stromal cell of Giant_Cell_Tumor_of_bone .
26449831	0	Runx2	96,101	MiR-30a	0,7	Runx2	MiR-30a	860	407029	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MiR-30a regulates the proliferation , migration , and invasion of human osteosarcoma by targeting Runx2 .
20039258	0	Runx2	23,28	MicroRNA-204	0,12	Runx2	MicroRNA-204	860	406987	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation .
17103021	0	Runx2	65,70	NFATc2	14,20	Runx2	NFATc2	12393(Tax:10090)	18019(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of NFATc2 gene expression by the transcription factor Runx2 .
20939017	0	Runx2	37,42	Nell-1	0,6	Runx2	Nell-1	12393(Tax:10090)	338352(Tax:10090)	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|appos|mediator	Nell-1 , a key functional mediator of Runx2 , partially rescues calvarial_defects in Runx2 -LRB- + / - -RRB- mice .
20939017	0	Runx2	83,88	Nell-1	0,6	Runx2	Nell-1	12393(Tax:10090)	338352(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY calvarial_defects|nmod|mice rescues|dobj|calvarial_defects rescues|nsubj|END_ENTITY	Nell-1 , a key functional mediator of Runx2 , partially rescues calvarial_defects in Runx2 -LRB- + / - -RRB- mice .
18804520	0	Runx2	54,59	Odd-skipped_related_1	0,21	Runx2	Odd-skipped related 1	12393(Tax:10090)	23967(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Odd-skipped_related_1 gene expression is regulated by Runx2 and Ikzf1 transcription factors .
23468178	0	Runx2	16,21	PCAF	0,4	Runx2	PCAF	12393(Tax:10090)	18519(Tax:10090)	Gene	Gene	acetylates|dobj|START_ENTITY acetylates|nsubj|END_ENTITY	PCAF acetylates Runx2 and promotes osteoblast differentiation .
21915903	0	Runx2	33,38	Pannexin_3	0,10	Runx2	Pannexin 3	12393(Tax:10090)	208098(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Pannexin_3 is a novel target for Runx2 , expressed by osteoblasts and mature growth plate chondrocytes .
15302580	0	Runx2	53,58	Parathyroid_hormone-related_peptide	0,35	Runx2	Parathyroid hormone-related peptide	373919(Tax:9031)	396281(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Parathyroid_hormone-related_peptide -LRB- PTHrP -RRB- inhibits Runx2 expression through the PKA signaling pathway .
15668330	0	Runx2	0,5	Shh	23,26	Runx2	Shh	12393(Tax:10090)	20423(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Runx2 -LRB- Cbfa1 -RRB- inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth .
17215250	0	Runx2	107,112	Smad6	39,44	Runx2	Smad6	860	4091	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Bone_morphogenetic_protein_2 activates Smad6 gene transcription through bone-specific transcription factor Runx2 .
21445983	0	Runx2	65,70	Spata4	0,6	Runx2	Spata4	12393(Tax:10090)	69281(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY promotes|nmod|pathway promotes|nsubj|END_ENTITY	Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway .
12923053	0	Runx2	47,52	Stat1	0,5	Runx2	Stat1	12393(Tax:10090)	20846(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation .
22575641	0	Runx2	73,78	TAZ	60,63	Runx2	TAZ	860	6901	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Phorbaketal_A stimulates osteoblast differentiation through TAZ mediated Runx2 activation .
20890621	0	Runx2	22,27	Tcf7	14,18	Runx2	Tcf7	12393(Tax:10090)	21414(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation .
23846726	0	Runx2	46,51	Thrombospondin-1	0,16	Runx2	Thrombospondin-1	12393(Tax:10090)	21825(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Thrombospondin-1 is a putative target gene of Runx2 and Runx3 .
25865393	0	Runx2	41,46	Ucma	0,4	Runx2	Ucma	12393(Tax:10090)	68527(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Ucma , a direct transcriptional target of Runx2 and Osterix , promotes osteoblast differentiation and nodule formation .
25865393	0	Runx2	41,46	Ucma	0,4	Runx2	Ucma	12393(Tax:10090)	68527(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Ucma , a direct transcriptional target of Runx2 and Osterix , promotes osteoblast differentiation and nodule formation .
25188294	0	Runx2	73,78	Whsc1	39,44	Runx2	Whsc1	860	7468	Gene	Gene	association|nmod|START_ENTITY promotes|dobj|association promotes|nsubj|END_ENTITY	Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes .
24520423	0	Runx2	92,97	b-catenin	0,9	Runx2	b-catenin	860	1499	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	b-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2 .
21163272	0	Runx2	114,119	bone_morphogenetic_protein-2	61,89	Runx2	bone morphogenetic protein-2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY activate|dobj|transcription accelerates|advcl|activate accelerates|nmod|p38 p38|amod|END_ENTITY	8-Prenylkaempferol accelerates osteoblast maturation through bone_morphogenetic_protein-2 / p38 pathway to activate Runx2 transcription .
25625570	0	Runx2	127,132	bone_morphogenetic_protein-2	78,106	Runx2	bone morphogenetic protein-2	12393(Tax:10090)	12156(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Radix_Dipsaci_total_saponins stimulate MC3T3-E1 cell differentiation via the bone_morphogenetic_protein-2 / MAPK/Smad-dependent Runx2 pathway .
12933820	0	Runx2	176,181	bone_morphogenetic_protein_2	6,34	Runx2	bone morphogenetic protein 2	860	650	Gene	Gene	alteration|nmod|START_ENTITY rescues|nmod|alteration rescues|nsubj|treatment treatment|amod|END_ENTITY	Brief bone_morphogenetic_protein_2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx2 .
18755791	0	Runx2	14,19	estrogen_receptor-alpha	32,55	Runx2	estrogen receptor-alpha	860	2099	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Modulation of Runx2 activity by estrogen_receptor-alpha : implications for osteoporosis and breast_cancer .
17439743	0	Runx2	40,45	fibroblast_growth_factor_9	10,36	Runx2	fibroblast growth factor 9	12393(Tax:10090)	14180(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effect of fibroblast_growth_factor_9 on Runx2 gene promoter activity in MC3T3-E1 and C2C12 cells .
12391164	0	Runx2	0,5	histone_deacetylase_6	36,57	Runx2	histone deacetylase 6	860	10013	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Runx2 -LRB- Cbfa1 , AML-3 -RRB- interacts with histone_deacetylase_6 and represses the p21 -LRB- CIP1/WAF1 -RRB- promoter .
19029091	0	Runx2	119,124	histone_deacetylase_7	66,87	Runx2	histone deacetylase 7	860	51564	Gene	Gene	localization|nmod|START_ENTITY localization|amod|END_ENTITY	Bone_morphogenic_protein_2 activates protein_kinase_D to regulate histone_deacetylase_7 localization and repression of Runx2 .
26596830	0	Runx2	89,94	miR-30a	22,29	Runx2	miR-30a	860	407029	Gene	Gene	chondrosarcoma|nmod|START_ENTITY proliferation|nmod|chondrosarcoma affects|dobj|proliferation affects|nsubj|overexpression overexpression|nmod|END_ENTITY	The overexpression of miR-30a affects cell proliferation of chondrosarcoma via targeting Runx2 .
11668178	0	Runx2	114,119	osteocalcin	64,75	Runx2	osteocalcin	367218(Tax:10116)	81613(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	CCAAT/enhancer-binding _ proteins -LRB- C/EBP -RRB- _ beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression .
19423655	0	Runx2	0,5	p300	15,19	Runx2	p300	860	2033	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|END_ENTITY	Runx2 recruits p300 to mediate parathyroid hormone 's effects on histone acetylation and transcriptional activation of the matrix_metalloproteinase-13 gene .
16549373	0	Runx2	146,151	p38	165,168	Runx2	p38	860	1432	Gene	Gene	START_ENTITY|acl|mediating mediating|dobj|effects effects|amod|END_ENTITY	Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells : potential role of Runx2 in mediating p38 effects .
16549373	0	Runx2	146,151	p38	75,78	Runx2	p38	860	1432	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|MMP-1 MMP-1|nmod|inhibitors inhibitors|amod|END_ENTITY	Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells : potential role of Runx2 in mediating p38 effects .
17334410	0	Runx2	111,116	p38	23,26	Runx2	p38	367218(Tax:10116)	81649(Tax:10116)	Gene	Gene	downregulation|nmod|START_ENTITY exerts|nmod|downregulation exerts|nsubj|FR-167653 FR-167653|appos|inhibitor inhibitor|amod|END_ENTITY	FR-167653 , a selective p38 MAPK inhibitor , exerts salutary effect on liver cirrhosis through downregulation of Runx2 .
20564243	0	Runx2	112,117	p38	94,97	Runx2	p38	860	1432	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation .
21163272	0	Runx2	114,119	p38	90,93	Runx2	p38	12393(Tax:10090)	26416(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY activate|dobj|transcription accelerates|advcl|activate accelerates|nmod|END_ENTITY	8-Prenylkaempferol accelerates osteoblast maturation through bone_morphogenetic_protein-2 / p38 pathway to activate Runx2 transcription .
21806985	0	Runx2	124,129	p38	83,86	Runx2	p38	860	1432	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Ugonin_K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK - and ERK-mediated expression of Runx2 and osterix .
17960593	0	Runx2	26,31	p68	0,3	Runx2	p68	12393(Tax:10090)	13207(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	p68 -LRB- Ddx5 -RRB- interacts with Runx2 and regulates osteoblast differentiation .
11073979	0	Runx2	0,5	transforming_growth_factor_beta1	28,60	Runx2	transforming growth factor beta1	12393(Tax:10090)	21803(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Runx2 is a common target of transforming_growth_factor_beta1 and bone_morphogenetic_protein_2 , and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12 .
15183720	0	Runx2-Cbfa1	63,74	Grg5	18,22	Runx2-Cbfa1	Grg5	12393(Tax:10090)	14797(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice .
19338776	0	Runx3	0,5	IL-4	15,19	Runx3	IL-4	12399(Tax:10090)	16189(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Runx3 inhibits IL-4 production in T cells via physical interaction with NFAT .
17662272	0	Runx3	0,5	Ku70	40,44	Runx3	Ku70	864	2547	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Runx3 interacts with DNA repair protein Ku70 .
17352693	0	Runx3	0,5	Osterix	27,34	Runx3	Osterix	12399(Tax:10090)	170574(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Runx3 negatively regulates Osterix expression in dental pulp cells .
24880459	0	Runx3	42,47	ThPOK	25,30	Runx3	ThPOK	864	51043	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	The transcription factor ThPOK suppresses Runx3 and imposes CD4 -LRB- + -RRB- lineage fate by inducing the SOCS suppressors of cytokine signaling .
17584746	0	Runx3	25,30	TrkB	67,71	Runx3	TrkB	864	4915	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons .
21763315	0	RuvBl2	0,6	Ets2	23,27	RuvBl2	Ets2	10856	2114	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon_cancer .
22385341	0	Rv0652	27,33	tumour_necrosis_factor	59,81	Rv0652	tumour necrosis factor	888078(Tax:83332)	21926(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Mycobacterium_tuberculosis Rv0652 stimulates production of tumour_necrosis_factor and monocytes chemoattractant protein-1 in macrophages through the Toll-like receptor 4 pathway .
18289677	0	Rv2108	108,114	p27	103,106	Rv2108	p27	887814(Tax:83332)	12576(Tax:10090)	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Flagellin as a good carrier and potent adjuvant for Th1 response : study of mice immune response to the p27 -LRB- Rv2108 -RRB- Mycobacterium_tuberculosis antigen .
26212120	0	Rv2970c	26,33	LipN	20,24	Rv2970c	LipN	887194(Tax:83332)	887194(Tax:83332)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of LipN -LRB- Rv2970c -RRB- of Mycobacterium_Tuberculosis_H37Rv and Its Probable Role in Xenobiotic Degradation .
16754985	0	Rv3290c	85,92	lysine_epsilon-aminotransferase	52,83	Rv3290c	lysine epsilon-aminotransferase	887904(Tax:83332)	887904(Tax:83332)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression , purification and crystallization of lysine_epsilon-aminotransferase -LRB- Rv3290c -RRB- from Mycobacterium_tuberculosis_H37Rv .
26681517	0	Rvs161p	52,59	Fus2p	30,35	Rvs161p	Fus2p	850367(Tax:4932)	855272(Tax:4932)	Gene	Gene	Interaction|compound|START_ENTITY Required|nmod|Interaction Required|nsubjpass|Domain Domain|nmod|END_ENTITY	An Amphiphysin-like Domain in Fus2p is Required for Rvs161p Interaction and Cortical Localization .
9566960	0	Rvs161p	0,7	Fus2p	23,28	Rvs161p	Fus2p	850367(Tax:4932)	855272(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces_cerevisiae .
17003412	0	Rx-L	27,31	Rx-like	4,11	Rx-L	Rx-like	734229(Tax:8355)	734229(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Rx-like homeobox gene -LRB- Rx-L -RRB- is necessary for normal photoreceptor development .
17003412	0	Rx-like	4,11	Rx-L	27,31	Rx-like	Rx-L	734229(Tax:8355)	734229(Tax:8355)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Rx-like homeobox gene -LRB- Rx-L -RRB- is necessary for normal photoreceptor development .
19416211	0	Rxfp2	14,19	Lgr8	21,25	Rxfp2	Lgr8	140498(Tax:10090)	140498(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of Rxfp2 -LRB- Lgr8 -RRB- expression in the mouse fetal kidney by the transcription factor Pod1 -LRB- Tcf_21 -RRB- .
25257104	0	Rxfp3	20,25	Relaxin-3	0,9	Rxfp3	Relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
26278401	0	Rxfp3	20,25	Relaxin-3	0,9	Rxfp3	Relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	reduces|dep|START_ENTITY reduces|nsubj|receptor receptor|amod|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene deletion reduces operant sucrose - but not alcohol-responding in mice .
26278401	0	Rxfp3	20,25	Relaxin-3	0,9	Rxfp3	Relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	reduces|dep|START_ENTITY reduces|nsubj|receptor receptor|amod|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene deletion reduces operant sucrose - but not alcohol-responding in mice .
25257104	0	Rxfp3	20,25	relaxin-3	111,120	Rxfp3	relaxin-3	239336(Tax:10090)	212108(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|Implications Implications|nmod|role role|nmod|signalling signalling|amod|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
26735137	0	RyDEN	20,25	C19orf66	27,35	RyDEN	C19orf66	55337	55337	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of RyDEN -LRB- C19orf66 -RRB- as an Interferon-Stimulated Cellular Inhibitor against Dengue_Virus Replication .
24254650	0	RyR	95,98	ryanodine_receptor	75,93	RyR	ryanodine receptor	6261	6261	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	A comparative study indicates both positive and purifying selection within ryanodine_receptor -LRB- RyR -RRB- genes , as well as correlated evolution .
11964231	0	RyR1	19,23	Ca2	0,3	RyR1	Ca2	6261	760	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Ca2 + activation of RyR1 is not necessary for the initiation of skeletal-type excitation-contraction coupling .
12045220	0	RyR1	0,4	Ca2	54,57	RyR1	Ca2	6261	760	Gene	Gene	isoforms|nsubj|START_ENTITY isoforms|xcomp|provide provide|iobj|END_ENTITY	RyR1 and RyR3 isoforms provide distinct intracellular Ca2 + signals in HEK 293 cells .
17707505	0	RyR1	49,53	ryanodine_receptor_type_1	22,47	RyR1	ryanodine receptor type 1	6261	6261	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Dynamic regulation of ryanodine_receptor_type_1 -LRB- RyR1 -RRB- channel activity by Homer_1 .
22158709	0	RyR2	40,44	CaMKII	14,20	RyR2	CaMKII	20191(Tax:10090)	12325(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial_fibrillation in FKBP12 .6 knockout mice .
23246599	0	RyR2	40,44	CaMKII	14,20	RyR2	CaMKII	20191(Tax:10090)	12325(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular_arrhythmias in mice with Duchenne_muscular_dystrophy .
26080362	0	RyR2	42,46	CaMKII	0,6	RyR2	CaMKII	20191(Tax:10090)	12325(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY effects|nmod|phosphorylation mediates|dobj|effects mediates|nsubj|END_ENTITY	CaMKII mediates b-adrenergic effects on RyR2 phosphorylation and SR Ca -LRB- 2 + -RRB- leak and the pathophysiological response to chronic b-adrenergic stimulation .
19781797	0	RyR2	20,24	Ryanodine_receptor	0,18	RyR2	Ryanodine receptor	6262	6262	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Ryanodine_receptor -LRB- RyR2 -RRB- mutations in sudden cardiac_death : studies in extended pedigrees and phenotypic characterization in vitro .
18419777	0	RyR2	77,81	ryanodine_receptor	57,75	RyR2	ryanodine receptor	20191(Tax:10090)	20191(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Physiological consequences of the P2328S mutation in the ryanodine_receptor -LRB- RyR2 -RRB- gene in genetically modified murine hearts .
25463374	0	RyR2	96,100	ryanodine_receptor	76,94	RyR2	ryanodine receptor	6262	6262	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Short-coupled polymorphic_ventricular_tachycardia at rest linked to a novel ryanodine_receptor -LRB- RyR2 -RRB- mutation : Leaky RyR2 channels under non-stress conditions .
9295356	0	RyR3	47,51	type_3_ryanodine_receptor	20,45	RyR3	type 3 ryanodine receptor	100009545(Tax:9986)	100009545(Tax:9986)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of type_3_ryanodine_receptor -LRB- RyR3 -RRB- of sarcoplasmic reticulum from rabbit skeletal muscles .
16176935	0	Ryanodine_receptor	0,18	FKBP12	30,36	Ryanodine receptor	FKBP12	6261	2280	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Ryanodine_receptor binding to FKBP12 is modulated by channel activation state .
19781797	0	Ryanodine_receptor	0,18	RyR2	20,24	Ryanodine receptor	RyR2	6262	6262	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Ryanodine_receptor -LRB- RyR2 -RRB- mutations in sudden cardiac_death : studies in extended pedigrees and phenotypic characterization in vitro .
17874297	0	Rybp	0,4	Hippi	20,25	Rybp	Hippi	56353(Tax:10090)	73916(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Rybp interacts with Hippi and enhances Hippi-mediated apoptosis .
19269974	0	Ryk	16,19	Cdc37	0,5	Ryk	Cdc37	6259	11140	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular_domain .
19269974	0	Ryk	57,60	Cdc37	0,5	Ryk	Cdc37	6259	11140	Gene	Gene	intracellular_domain|compound|START_ENTITY stabilizing|dobj|intracellular_domain signaling|advcl|stabilizing Ryk|acl|signaling regulates|dobj|Ryk regulates|nsubj|END_ENTITY	Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular_domain .
18809723	0	Ryk	0,3	Frizzled_7	20,30	Ryk	Frizzled 7	734495(Tax:8355)	378787(Tax:8355)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Ryk cooperates with Frizzled_7 to promote Wnt11-mediated endocytosis and is essential for Xenopus_laevis convergent extension movements .
10550517	0	S-0139	69,75	endothelin-A_receptor	35,56	S-0139	endothelin-A receptor	1076573(Tax:198215)	24326(Tax:10116)	Gene	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	A preventive effect of a selective endothelin-A_receptor antagonist , S-0139 , on the erythropoietin-induced reduction_of_the_renal_cortical_blood_flow .
18669895	0	S-0139	64,70	endothelin_type_A_receptor	25,51	S-0139	endothelin type A receptor	1076573(Tax:198215)	24326(Tax:10116)	Gene	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of an endothelin_type_A_receptor antagonist , S-0139 , with rtPA on the neuroprotection after embolic_stroke .
16619577	0	S-1	51,54	CPT-11	30,36	S-1	CPT-11	5707	963084(Tax:115711)	Gene	Gene	gastric_cancer|amod|START_ENTITY CDDP|nmod|gastric_cancer CDDP|nsubj|study study|nmod|plus plus|amod|END_ENTITY	Feasibility study of biweekly CPT-11 plus CDDP for S-1 - and paclitaxel-refractory , metastatic gastric_cancer .
18219915	0	S-1	93,96	CPT-11	99,105	S-1	CPT-11	5707	963084(Tax:115711)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A case of unresectable gastric_cancer successfully treated with combination chemotherapy of S-1 _ + _ CPT-11 -RSB- .
18219916	0	S-1	11,14	CPT-11	144,150	S-1	CPT-11	5707	963084(Tax:115711)	Gene	Gene	resistant|amod|START_ENTITY metastases|amod|resistant case|nmod|metastases -LSB-|dobj|case combined|csubj|-LSB- combined|nmod|END_ENTITY	-LSB- A case of S-1 resistant multiple lung metastases after curative total gastrectomy for gastric_cancer successfully treated by S-1 combined with CPT-11 as the third-line chemotherapy -RSB- .
18219916	0	S-1	126,129	CPT-11	144,150	S-1	CPT-11	5707	963084(Tax:115711)	Gene	Gene	treated|nmod|START_ENTITY gastric_cancer|acl|treated gastrectomy|nmod|gastric_cancer -LSB-|nmod|gastrectomy combined|csubj|-LSB- combined|nmod|END_ENTITY	-LSB- A case of S-1 resistant multiple lung metastases after curative total gastrectomy for gastric_cancer successfully treated by S-1 combined with CPT-11 as the third-line chemotherapy -RSB- .
18799912	0	S-1	156,159	CPT-11	175,181	S-1	CPT-11	5707	963084(Tax:115711)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- A case of advanced gastric_cancer with pulmonary_carcinomatous_lymphangitis and paraaortic_lymph_node_metastases responding to combination chemotherapy of S-1 and irinotecan -LRB- CPT-11 -RRB- -RSB- .
19692782	0	S-1	18,21	CPT-11	27,33	S-1	CPT-11	5707	963084(Tax:115711)	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	-LSB- Effectiveness of S-1 plus CPT-11 therapy for an elderly patient with recurrent colon_cancer -RSB- .
20087049	0	S-1	63,66	CPT-11	72,78	S-1	CPT-11	5707	963084(Tax:115711)	Gene	Gene	chemotherapy|compound|START_ENTITY chemotherapy|compound|END_ENTITY	-LSB- A case of advanced gastric_cancer with a complete response to S-1 plus CPT-11 chemotherapy for eight years -RSB- .
20630899	0	S-1	46,49	S-1	74,77	S-1	S-1	5707	5707	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Randomized phase II study of gemcitabine plus S-1 combination therapy vs. S-1 in advanced biliary_tract_cancer : Japan Clinical Oncology Group Study -LRB- JCOG0805 -RRB- .
20630899	0	S-1	74,77	S-1	46,49	S-1	S-1	5707	5707	Gene	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Randomized phase II study of gemcitabine plus S-1 combination therapy vs. S-1 in advanced biliary_tract_cancer : Japan Clinical Oncology Group Study -LRB- JCOG0805 -RRB- .
22020317	0	S-1	107,110	S-1	70,73	S-1	S-1	5707	5707	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Effect of food and a proton pump inhibitor on the pharmacokinetics of S-1 following oral administration of S-1 in patients with advanced solid tumors .
22020317	0	S-1	70,73	S-1	107,110	S-1	S-1	5707	5707	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Effect of food and a proton pump inhibitor on the pharmacokinetics of S-1 following oral administration of S-1 in patients with advanced solid tumors .
20066556	0	S-1	51,54	matrix_metalloproteinase-12	12,39	S-1	Matrix metalloproteinase-12	13628(Tax:10090)	17381(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effect of a matrix_metalloproteinase-12 inhibitor , S-1 , on allergic airway_disease phenotypes in mice .
17203218	0	S-1	0,3	vascular_endothelial_growth_factor	138,172	S-1	vascular endothelial growth factor	5707	22339(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	S-1 inhibits tumorigenicity and angiogenesis of human oral_squamous_cell_carcinoma cells by suppressing expression of phosphorylated Akt , vascular_endothelial_growth_factor and fibroblast_growth_factor-2 .
21469977	0	S-100	31,36	CD80	73,77	S-100	CD80	6285	941	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and distribution of S-100 , CD83 , and costimulatory molecules -LRB- CD80 and CD86 -RRB- in tissues of thyroid_papillary_carcinoma .
18162459	0	S-100	31,36	CD83	46,50	S-100	CD83	6285	9308	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression and distribution of S-100 protein , CD83 and apoptosis-related proteins -LRB- Fas , FasL and Bcl-2 -RRB- in thyroid tissues of autoimmune_thyroid_diseases .
3101377	0	S-100	29,34	NSE	72,75	S-100	NSE	6285	2026	Gene	Gene	protein|compound|START_ENTITY study|nmod|protein study|appos|END_ENTITY	Immunohistochemical study of S-100 protein and neuron_specific_enolase -LRB- NSE -RRB- in melanocytes and the related tumors .
3420027	0	S-100	0,5	NSE	43,46	S-100	NSE	6285	2026	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	S-100 protein and neuron_specific_enolase -LRB- NSE -RRB- expression by chordomas in relation to the composition of their stromal mucosubstances .
9137895	0	S-100	25,30	Neuron-specific_enolase	0,23	S-100	Neuron-specific enolase	6285	2026	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Neuron-specific_enolase , S-100 protein , myelin_basic_protein and lactate in CSF in dementia .
18359707	0	S-100	33,38	SMA	28,31	S-100	SMA	6285	6606	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of CD117 , CD34 , SMA , S-100 protein , Vim and desmin in patients with gastrointestinal_stromal_tumors -RSB- .
4797840	0	S-100	36,41	brain-specific_protein	12,34	S-100	brain-specific protein	6285	51673	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Effect of a brain-specific_protein -LRB- S-100 protein -RRB- on the nucleolar RNA polymerase activity in isolated brain nuclei .
21071131	0	S-100B	0,6	NSE	22,25	S-100B	NSE	6285	2026	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	S-100B is superior to NSE , BDNF and GFAP in predicting outcome of resuscitation from cardiac_arrest with hypothermia treatment .
25318158	0	S-100B	38,44	VEGF	13,17	S-100B	VEGF	6285	7422	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|role role|nmod|END_ENTITY	-LSB- The role of VEGF , HSP-70 and protein S-100B in the potentiation effect of the neuroprotective effect of hypercapnic hypoxia -RSB- .
19535196	0	S-100B	6,12	neuron-specific_enolase	28,51	S-100B	neuron-specific enolase	6285	2026	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|END_ENTITY	Serum S-100B is superior to neuron-specific_enolase as an early prognostic biomarker for neurological outcome following cardiopulmonary resuscitation .
1424333	0	S-100b	108,114	neuron-specific_enolase	83,106	S-100b	neuron-specific enolase	6285	2026	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	-LSB- Central_nervous_system_disorders in myotonic_dystrophy -- with special reference to neuron-specific_enolase , S-100b protein and creatine_kinase_BB isoenzyme levels in CSF -RSB- .
21251388	0	S-100b	89,95	neuron-specific_enolase	64,87	S-100b	neuron-specific enolase	6285	2026	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	-LSB- Effects of recombinant human erythropoietin on serum levels of neuron-specific_enolase , S-100b protein and myelin_basic_protein in rats following status_epilepticus -RSB- .
2791404	0	S-100b	131,137	neuron-specific_enolase	106,129	S-100b	neuron-specific enolase	6285	2026	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	-LSB- Cerebrospinal fluid level of aldolase_C in patients with various neurological_disorders : comparison with neuron-specific_enolase , S-100b protein and creatine_kinase_BB_isoenzyme -RSB- .
18834876	0	S-2678	92,98	dihydroorotate_dehydrogenase	52,80	S-2678	dihydroorotate dehydrogenase	1078950(Tax:198215)	56749(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Suppression of immunoglobulin production by a novel dihydroorotate_dehydrogenase inhibitor , S-2678 .
11483602	0	S-AKAP84	94,102	AMY-1	0,5	S-AKAP84	AMY-1	8165	26292	Gene	Gene	association|nmod|START_ENTITY localized|nmod|association localized|nsubj|END_ENTITY	AMY-1 , a c-Myc-binding_protein , is localized in the mitochondria of sperm by association with S-AKAP84 , an anchor protein of cAMP-dependent protein kinase .
12414807	0	S-AKAP84	21,29	AMY-1	0,5	S-AKAP84	AMY-1	8165	26292	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus , respectively , and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein -LRB- AKAP -RRB- complex .
8866660	0	S-adenosyl-L-homocysteine_hydrolase	28,63	C1300	67,72	S-adenosyl-L-homocysteine hydrolase	C1300	269378(Tax:10090)	1034995(Tax:199310)	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Resistance to inhibitors of S-adenosyl-L-homocysteine_hydrolase in C1300 murine neuroblastoma_tumor cells is associated with increased methionine adenosyltransferase activity .
8168479	0	S-adenosylhomocysteine_hydrolase	55,87	Ahcy	89,93	S-adenosylhomocysteine hydrolase	Ahcy	269378(Tax:10090)	269378(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse lethal nonagouti -LRB- a -LRB- x -RRB- -RRB- mutation deletes the S-adenosylhomocysteine_hydrolase -LRB- Ahcy -RRB- gene .
11099469	0	S-adenosylmethionine	0,20	MAT1A	31,36	S-adenosylmethionine	MAT1A	25331(Tax:10116)	25331(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes : a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver .
11032186	0	S-adenosylmethionine_decarboxylase	18,52	SAMDC	54,59	S-adenosylmethionine decarboxylase	SAMDC	380052(Tax:8355)	380052(Tax:8355)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of S-adenosylmethionine_decarboxylase -LRB- SAMDC -RRB- activates the maternal program of apoptosis shortly after MBT in Xenopus embryos .
7948879	0	S-adenosylmethionine_decarboxylase	24,58	SAMDC	60,65	S-adenosylmethionine decarboxylase	SAMDC	102601725	102601725	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterisation of the S-adenosylmethionine_decarboxylase -LRB- SAMDC -RRB- gene of potato .
7980467	0	S-adenosylmethionine_synthetase	46,77	Protein_kinase_C	0,16	S-adenosylmethionine synthetase	Protein kinase C	25331(Tax:10116)	24681(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Protein_kinase_C phosphorylation of rat liver S-adenosylmethionine_synthetase : dissociation and production of an active monomer .
3493642	0	S-antigen	29,38	Interleukin_2	1,14	S-antigen	Interleukin 2	25539(Tax:10116)	116562(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	-LSB- Interleukin_2 production in S-antigen immunized rats and effects of cyclosporine -RSB- .
17483325	0	S-phase_kinase-associated_protein_2	45,80	E2F1	99,103	S-phase kinase-associated protein 2	E2F1	6502	1869	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Phosphoinositide-3-kinase signaling controls S-phase_kinase-associated_protein_2 transcription via E2F1 in pancreatic_ductal_adenocarcinoma cells .
15700547	0	S-phase_kinase-associated_protein_2	15,50	SKP2	52,56	S-phase kinase-associated protein 2	SKP2	6502	6502	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of S-phase_kinase-associated_protein_2 -LRB- SKP2 -RRB- on cell cycle status , viability , and chemoresistance in A549 lung_adenocarcinoma cells .
11943729	0	S-phase_kinase-associated_protein_2	0,35	p27	99,102	S-phase kinase-associated protein 2	p27	6502	3429	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|amod|END_ENTITY	S-phase_kinase-associated_protein_2 expression in non-Hodgkin 's _ lymphoma inversely correlates with p27 expression and defines cells in S phase .
3754869	1	S-protein	120,129	antithrombin_III	135,151	S-protein	antithrombin III	7448	462	Gene	Gene	Protection|nmod|START_ENTITY Protection|nmod|inactivation inactivation|amod|END_ENTITY	Protection of thrombin by S-protein from antithrombin_III inactivation .
2409614	0	S-protein	89,98	complement_S-protein	15,35	S-protein	complement S-protein	7448	7448	Gene	Gene	role|nmod|START_ENTITY Interaction|dep|role Interaction|nmod|END_ENTITY	Interaction of complement_S-protein with thrombin-antithrombin complexes : a role for the S-protein in haemostasis .
2433863	0	S-protein	29,38	vitronectin	16,27	S-protein	vitronectin	7448	7448	Gene	Gene	Localization|dep|START_ENTITY Localization|nmod|END_ENTITY	Localization of vitronectin -LRB- S-protein of complement -RRB- in normal human skin .
3238653	0	S-protein	63,72	vitronectin	50,61	S-protein	vitronectin	7448	7448	Gene	Gene	Interaction|dep|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin-stimulated platelets with vitronectin -LRB- S-protein of complement -RRB- substrate : inhibition by a monoclonal antibody to glycoprotein_IIb-IIIa_complex .
8812496	0	S1-5	50,54	FBNL	61,65	S1-5	FBNL	2202	2202	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and chromosomal assignment of the human S1-5 gene -LRB- FBNL -RRB- that is highly homologous to fibrillin .
11121577	0	S10	13,16	S16	18,21	S10	S16	6204	6217	Gene	Gene	Proteins|nummod|START_ENTITY Proteins|nummod|END_ENTITY	Proteins S7 , S10 , S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt .
25760235	0	S100	40,44	Annexin_II	90,100	S100	Annexin II	6285	302	Gene	Gene	Domain|compound|START_ENTITY Structure|nmod|Domain Structure|nmod|END_ENTITY	Crystal Structure of Human Profilaggrin S100 Domain and Identification of Target Proteins Annexin_II , Stratifin , and HSP27 .
7691652	0	S100	0,4	CD1	63,66	S100	CD1	6271	911	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	S100 protein and neuron-specific_enolase on monocytic leukemic CD1 + cells , probable precursors of Langerhans cells .
8592003	0	S100	0,4	CP-10	13,18	S100	CP-10	6271	6279	Gene	Gene	stimulates|compound|START_ENTITY stimulates|compound|END_ENTITY	S100 protein CP-10 stimulates myeloid cell chemotaxis without activation .
9389698	0	S100	17,21	CP-10	43,48	S100	CP-10	20193(Tax:10090)	20201(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Induction of the S100 chemotactic protein , CP-10 , in murine microvascular endothelial cells by proinflammatory stimuli .
22727333	0	S100	13,17	Hornerin	0,8	S100	Hornerin	6285	388697	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Hornerin , an S100 family protein , is functional in breast cells and aberrantly expressed in breast_cancer .
15170138	0	S100	26,30	MIA	65,68	S100	MIA	6271	8190	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Clinical value of protein S100 and melanoma-inhibitory_activity -LRB- MIA -RRB- in malignant_melanoma .
9202034	0	S100	28,32	P11	0,3	S100	P11	6285	6281	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	P11 , a unique member of the S100 family of calcium-binding proteins , interacts with and inhibits the activity of the 85-kDa cytosolic_phospholipase_A2 .
8878558	0	S100	86,90	S100A13	57,64	S100	S100A13	6285	20196(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Characterization of the human and mouse cDNAs coding for S100A13 , a new member of the S100 protein family .
25573795	0	S100-B	15,21	PAPP-A	23,29	S100-B	PAPP-A	6285	5069	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Maternal Serum S100-B , PAPP-A and IL-6 levels in severe preeclampsia .
9920729	0	S100A1	173,179	GFAP	201,205	S100A1	GFAP	6271	2670	Gene	Gene	effect|compound|START_ENTITY effect|nmod|polymerization polymerization|compound|END_ENTITY	Role of the C-terminal extension in the interaction of S100A1 with GFAP , tubulin , the S100A1 - and S100B-inhibitory peptide , TRTK-12 , and a peptide derived from p53 , and the S100A1 inhibitory effect on GFAP polymerization .
9920729	0	S100A1	55,61	GFAP	67,71	S100A1	GFAP	6271	2670	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the C-terminal extension in the interaction of S100A1 with GFAP , tubulin , the S100A1 - and S100B-inhibitory peptide , TRTK-12 , and a peptide derived from p53 , and the S100A1 inhibitory effect on GFAP polymerization .
21372205	0	S100A10	22,29	DLC1	0,4	S100A10	DLC1	81778(Tax:10116)	58834(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung_cancer cells through a RhoGAP-independent mechanism .
13679511	0	S100A10	14,21	annexin_2	4,13	S100A10	annexin 2	81778(Tax:10116)	56611(Tax:10116)	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	The annexin_2 / S100A10 complex controls the distribution of transferrin_receptor-containing recycling endosomes .
14699089	0	S100A10	37,44	annexin_2	27,36	S100A10	annexin 2	81778(Tax:10116)	56611(Tax:10116)	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	AHNAK interaction with the annexin_2 / S100A10 complex regulates cell membrane cytoarchitecture .
16285733	0	S100A10	68,75	annexin_A2	57,67	S100A10	annexin A2	6281	302	Gene	Gene	heterotetramer|compound|START_ENTITY heterotetramer|amod|END_ENTITY	Phosphatidylserine membrane domain clustering induced by annexin_A2 / S100A10 heterotetramer .
20085458	0	S100A10	14,21	annexin_A2	89,99	S100A10	annexin A2	6281	302	Gene	Gene	tracer|compound|START_ENTITY used|nsubj|tracer used|xcomp|identify identify|nmod|END_ENTITY	A Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin_A2 .
23091277	0	S100A10	53,60	annexin_A2	26,36	S100A10	annexin A2	6281	302	Gene	Gene	binding|compound|START_ENTITY required|nmod|binding required|nsubjpass|acetylation acetylation|nmod|END_ENTITY	N-terminal acetylation of annexin_A2 is required for S100A10 binding .
23193360	0	S100A10	15,22	annexin_A2	4,14	S100A10	annexin A2	6281	302	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	The annexin_A2 / S100A10 system in health and disease : emerging paradigms .
23246849	0	S100A11	29,36	annexin_A1	18,28	S100A11	annexin A1	6282	301	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Disruption of the annexin_A1 / S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial_growth_factor -LRB- EGF -RRB- signaling .
15668896	0	S100A11	27,34	calgizzarin	36,47	S100A11	calgizzarin	6282	6282	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Dysregulated expression of S100A11 -LRB- calgizzarin -RRB- in prostate_cancer and precursor lesions .
16327996	0	S100A11	37,44	calgizzarin	24,35	S100A11	calgizzarin	6282	6282	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Different expression of calgizzarin -LRB- S100A11 -RRB- in normal colonic epithelium , adenoma and colorectal_carcinoma .
25110868	0	S100A12	30,37	C/EBPb	65,71	S100A12	C/EBPb	100301483(Tax:9823)	397360(Tax:9823)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The inflammation-related gene S100A12 is positively regulated by C/EBPb and AP-1 in pigs .
8985590	0	S100A12	30,37	CAAF1	58,63	S100A12	CAAF1	6283	6283	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the human S100A12 -LRB- calgranulin_C , p6 , CAAF1 , CGRP -RRB- gene , a new member of the S100 gene cluster on chromosome 1q21 .
12832680	0	S100A12	14,21	EN-RAGE	23,30	S100A12	EN-RAGE	6283	6283	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of S100A12 -LRB- EN-RAGE -RRB- in cystic_fibrosis .
12832707	0	S100A12	43,50	EN-RAGE	52,59	S100A12	EN-RAGE	6283	6283	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the pro-inflammatory protein S100A12 -LRB- EN-RAGE -RRB- in rheumatoid_and_psoriatic_arthritis .
15531492	0	S100A12	17,24	EN-RAGE	26,33	S100A12	EN-RAGE	6283	6283	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Increased plasma S100A12 -LRB- EN-RAGE -RRB- levels in patients with type 2 diabetes .
18663285	0	S100A12	17,24	EN-RAGE	26,33	S100A12	EN-RAGE	6283	6283	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Increased plasma S100A12 -LRB- EN-RAGE -RRB- levels in hemodialysis patients with atherosclerosis .
10973813	0	S100A12	22,29	MRP-14	35,41	S100A12	MRP-14	6283	6280	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of human S100A12 with MRP-14 -LRB- S100A9 -RRB- .
10464253	0	S100A12	0,7	MRP8	77,81	S100A12	MRP8	6283	6279	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14 .
8878558	0	S100A13	57,64	S100	86,90	S100A13	S100	20196(Tax:10090)	6285	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Characterization of the human and mouse cDNAs coding for S100A13 , a new member of the S100 protein family .
24532790	0	S100A14	88,95	Kruppel-like_transcription_factor_4	107,142	S100A14	Kruppel-like transcription factor 4	57402	9314	Gene	Gene	level|compound|START_ENTITY level|nmod|END_ENTITY	12-O-tetradecanoylphorbol-13-acetate promotes breast_cancer cell motility by increasing S100A14 level in a Kruppel-like_transcription_factor_4 -LRB- KLF4 -RRB- - dependent manner .
24086685	0	S100A14	0,7	S100A16	23,30	S100A14	S100A16	57402	140576	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	S100A14 interacts with S100A16 and regulates its expression in human cancer cells .
24086685	0	S100A16	23,30	S100A14	0,7	S100A16	S100A14	140576	57402	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	S100A14 interacts with S100A16 and regulates its expression in human cancer cells .
10094469	0	S100A2	40,46	p53	69,72	S100A2	p53	6273	7157	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Transcriptional activation of the human S100A2 promoter by wild-type p53 .
15941720	0	S100A2	28,34	p53	50,53	S100A2	p53	6273	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity .
16367903	0	S100A2	27,33	p53	120,123	S100A2	p53	6273	7157	Gene	Gene	expression|nmod|START_ENTITY expression|dep|significance significance|appos|relationship relationship|nmod|END_ENTITY	Differential expression of S100A2 and S100A4 in lung_adenocarcinomas : clinicopathological significance , relationship to p53 and identification of their target genes .
16449968	0	S100A2	0,6	p53	50,53	S100A2	p53	628324(Tax:10090)	22060(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY target|nsubj|gene target|nmod|homologues homologues|compound|END_ENTITY	S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation .
24556685	0	S100A2	0,6	p53	96,99	S100A2	p53	6273	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|roles roles|nmod|regulation regulation|nmod|stability stability|compound|END_ENTITY	S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability .
26065264	0	S100A3	1,7	Kaiso	32,37	S100A3	Kaiso	20197(Tax:10090)	56805(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	-LSB- S100A3 is a new target gene of Kaiso in mouse skin -RSB- .
11334142	0	S100A4	57,63	CAPL	65,69	S100A4	CAPL	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Optimization of hammerhead ribozymes for the cleavage of S100A4 -LRB- CAPL -RRB- mRNA .
15133476	0	S100A4	14,20	E-cadherin	43,53	S100A4	E-cadherin	6275	999	Gene	Gene	START_ENTITY|acl|combined combined|nmod|expression expression|amod|END_ENTITY	Expression of S100A4 combined with reduced E-cadherin expression predicts patient outcome in malignant_melanoma .
16297707	0	S100A4	0,6	E-cadherin	17,27	S100A4	E-cadherin	6275	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	S100A4 regulates E-cadherin expression in oral_squamous_cell_carcinoma .
16685438	0	S100A4	108,114	E-cadherin	73,83	S100A4	E-cadherin	6275	999	Gene	Gene	expression|compound|START_ENTITY decreased|advcl|expression decreased|dobj|END_ENTITY	Poor outcome of patients with pulmonary_adenocarcinoma showing decreased E-cadherin combined with increased S100A4 expression .
16865243	0	S100A4	10,16	E-cadherin	52,62	S100A4	E-cadherin	6275	999	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	Increased S100A4 expression combined with decreased E-cadherin expression predicts a poor outcome of patients with pancreatic_cancer .
19043527	0	S100A4	9,15	E-cadherin	116,126	S100A4	E-cadherin	6275	999	Gene	Gene	Expression|compound|START_ENTITY Expression|dep|Paralleled Paralleled|nmod|Reduction Reduction|compound|END_ENTITY	Frequent S100A4 Expression with Unique Splicing Pattern in Gastric_Cancers : A Hypomethylation Event Paralleled with E-cadherin Reduction and Wnt Activation .
26897964	0	S100A4	32,38	E-cadherin	42,52	S100A4	E-cadherin	6275	999	Gene	Gene	Regulation|nmod|START_ENTITY Mediates|dobj|Regulation Mediates|nmod|Expression Expression|compound|END_ENTITY	EZH2 Mediates the Regulation of S100A4 on E-cadherin Expression and the Proliferation , Migration of Gastric_Cancer Cells .
22782346	0	S100A4	27,33	EMMPRIN	0,7	S100A4	EMMPRIN	6275	682	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	EMMPRIN is associated with S100A4 and predicts patient outcome in colorectal_cancer .
26897964	0	S100A4	32,38	EZH2	0,4	S100A4	EZH2	6275	2146	Gene	Gene	Regulation|nmod|START_ENTITY Mediates|dobj|Regulation Mediates|nsubj|END_ENTITY	EZH2 Mediates the Regulation of S100A4 on E-cadherin Expression and the Proliferation , Migration of Gastric_Cancer Cells .
26721462	0	S100A4	46,52	MMP-13	87,93	S100A4	MMP-13	24615(Tax:10116)	171052(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Involvement of fibroblast-specific protein 1 -LRB- S100A4 -RRB- and matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- in CCl4-induced reversible liver_fibrosis .
18619032	0	S100A4	28,34	MTS1	22,26	S100A4	MTS1	6275	6275	Gene	Gene	Functions|appos|START_ENTITY Functions|nmod|END_ENTITY	-LSB- Functions of protein MTS1 -LRB- S100A4 -RRB- in normal and tumor cells -RSB- .
11018041	0	S100A4	49,55	Mts1	43,47	S100A4	Mts1	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Oligomeric forms of the metastasis-related Mts1 -LRB- S100A4 -RRB- protein stimulate neuronal differentiation in cultures of rat hippocampal neurons .
16265347	0	S100A4	0,6	Mts1	8,12	S100A4	Mts1	6275	6275	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	S100A4 -LRB- Mts1 -RRB- gene overexpression is associated with invasion and metastasis of papillary_thyroid_carcinoma .
24975844	0	S100A4	0,6	b-catenin	28,37	S100A4	b-catenin	6275	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	S100A4 negatively regulates b-catenin by inducing the Egr-1-PTEN-Akt-GSK3b degradation pathway .
10803111	0	S100A4	11,17	mts1	19,23	S100A4	mts1	6275	6275	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Absence of S100A4 -LRB- mts1 -RRB- gene mutations in various canine_and_feline_tumours .
15867373	0	S100A4	78,84	mts1	85,89	S100A4	mts1	20198(Tax:10090)	20198(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Suppression_of_tumor development and metastasis formation in mice lacking the S100A4 -LRB- mts1 -RRB- gene .
8824556	0	S100A4	16,22	mts1	10,14	S100A4	mts1	6275	6275	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of mts1 -LRB- S100A4 -RRB- expression on the progression of human breast_cancer cells .
23352991	0	S100A4	31,37	p53	102,105	S100A4	p53	20198(Tax:10090)	22060(Tax:10090)	Gene	Gene	mediates|nummod|START_ENTITY protein|appos|mediates cardiac_fibrosis|nsubj|protein cardiac_fibrosis|nmod|modulation modulation|nmod|END_ENTITY	Metastasis-associated protein , S100A4 mediates cardiac_fibrosis potentially through the modulation of p53 in cardiac fibroblasts .
23752197	0	S100A4	0,6	p53	22,25	S100A4	p53	6275	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	S100A4 interacts with p53 in the nucleus and promotes p53 degradation .
26497012	0	S100A4	0,6	p53	29,32	S100A4	p53	6275	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	S100A4 interacts with mutant p53 and affects gastric_cancer MKN1 cell autophagy and differentiation .
10738249	0	S100A4	41,47	p9Ka	49,53	S100A4	p9Ka	6275	6275	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Localisation by in situ hybridisation of S100A4 -LRB- p9Ka -RRB- mRNA in primary human breast_tumour specimens .
10749128	0	S100A4	59,65	p9Ka	67,71	S100A4	p9Ka	6275	6275	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of the metastasis-inducing protein S100A4 -LRB- p9Ka -RRB- in human breast_cancer .
11875708	0	S100A4	0,6	p9Ka	8,12	S100A4	p9Ka	6275	6275	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	S100A4 -LRB- p9Ka -RRB- protein in colon_carcinoma and liver metastases : association with carcinoma cells and T-lymphocytes .
9242709	0	S100A4	59,65	p9Ka	67,71	S100A4	p9Ka	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|appos|END_ENTITY	Transcriptional down-regulation of the metastasis-inducing S100A4 -LRB- p9Ka -RRB- in benign but not in malignant rat mammary epithelial cells by GC-factor .
9891019	0	S100A4	119,125	p9Ka	127,131	S100A4	p9Ka	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Differential reactivity of the rat S100A4 -LRB- p9Ka -RRB- gene to sodium_bisulfite is associated with differential levels of the S100A4 -LRB- p9Ka -RRB- mRNA in rat mammary epithelial cells .
9891019	0	S100A4	35,41	p9Ka	42,46	S100A4	p9Ka	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Differential reactivity of the rat S100A4 -LRB- p9Ka -RRB- gene to sodium_bisulfite is associated with differential levels of the S100A4 -LRB- p9Ka -RRB- mRNA in rat mammary epithelial cells .
19724273	0	S100A6	0,6	annexin_2	16,25	S100A6	annexin 2	6277	302	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	S100A6 binds to annexin_2 in pancreatic_cancer cells and promotes pancreatic_cancer cell motility .
22560296	0	S100A6	0,6	b-catenin	41,50	S100A6	b-catenin	6277	1499	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	S100A6 is transcriptionally regulated by b-catenin and interacts with a novel target , lamin_A / C , in colorectal_cancer cells .
26044826	0	S100A6	10,16	b-catenin	36,45	S100A6	b-catenin	6277	1499	Gene	Gene	over-expression|compound|START_ENTITY Effect|nmod|over-expression Effect|nmod|END_ENTITY	Effect of S100A6 over-expression on b-catenin in endometriosis .
11200185	0	S100A6	53,59	calcyclin	42,51	S100A6	calcyclin	6277	6277	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of cell specific expression of calcyclin -LRB- S100A6 -RRB- in nerve cells and other tissues .
16288473	0	S100A6	70,76	calcyclin	78,87	S100A6	calcyclin	6277	6277	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Binding and functional characteristics of two E-box motifs within the S100A6 -LRB- calcyclin -RRB- gene promoter .
18714402	0	S100A6	55,61	calcyclin	39,48	S100A6	calcyclin	6277	6277	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	P53-dependent suppression of the human calcyclin gene -LRB- S100A6 -RRB- : the role of Sp1 and of NFkappaB .
20013795	0	S100A6	0,6	calcyclin	8,17	S100A6	calcyclin	20200(Tax:10090)	20200(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	S100A6 -LRB- calcyclin -RRB- deficiency induces senescence-like changes in cell cycle , morphology and functional characteristics of mouse NIH 3T3 fibroblasts .
9497364	0	S100A6	25,31	calcyclin	14,23	S100A6	calcyclin	100348755(Tax:9986)	100348755(Tax:9986)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of calcyclin -LRB- S100A6 -RRB- binding by alternative splicing in the N-terminal regulatory domain of annexin_XI isoforms .
18765292	0	S100A6	0,6	p53	13,16	S100A6	p53	6277	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	S100A6 binds p53 and affects its activity .
23796514	0	S100A6	0,6	p53	60,63	S100A6	p53	6277	7157	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|domain domain|nmod|p300 p300|nmod|acetylation acetylation|amod|binding binding|nmod|END_ENTITY	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
23796514	0	S100A6	0,6	p53	79,82	S100A6	p53	6277	7157	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|domain domain|nmod|p300 p300|nmod|acetylation acetylation|compound|END_ENTITY	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
17986321	0	S100A7	0,6	IFN-gamma	89,98	S100A7	IFN-gamma	6278	3458	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	S100A7 -LRB- Psoriasin -RRB- , highly expressed in ductal_carcinoma in situ -LRB- DCIS -RRB- , is regulated by IFN-gamma in mammary epithelial cells .
27060579	0	S100A7	0,6	IL-6	72,76	S100A7	IL-6	6278	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|secretion secretion|compound|END_ENTITY	S100A7 -LRB- psoriasin -RRB- inhibits human epidermal differentiation by enhanced IL-6 secretion through IkB/NF-kB signaling .
20101226	0	S100A7	0,6	oncostatin-M	63,75	S100A7	oncostatin-M	6278	5008	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	S100A7 -LRB- psoriasin -RRB- is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast_cancer .
26608915	0	S100A8	0,6	CD11b	38,43	S100A8	CD11b	20201(Tax:10090)	16409(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	S100A8 Production in CXCR2-Expressing CD11b + Gr-1high Cells Aggravates Hepatitis in Mice Fed a High-Fat and High-Cholesterol Diet .
24103748	0	S100A8	32,38	Ephrin-A1	0,9	S100A8	Ephrin-A1	6279	1942	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Ephrin-A1 expression induced by S100A8 is mediated by the toll-like_receptor_4 .
24532576	0	S100A8	0,6	IL-10	15,20	S100A8	IL-10	20201(Tax:10090)	16153(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	S100A8 induces IL-10 and protects against acute_lung_injury .
25098409	0	S100A8	20,26	IL-10	87,92	S100A8	IL-10	20201(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|requires requires|dobj|END_ENTITY	TLR9 ligands induce S100A8 in macrophages via a STAT3-dependent pathway which requires IL-10 and PGE2 .
26135667	0	S100A8	21,27	Id3	38,41	S100A8	Id3	20201(Tax:10090)	15903(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Inflammation-induced S100A8 activates Id3 and promotes colorectal_tumorigenesis .
11342660	0	S100A8	61,67	Il-10	0,5	S100A8	Il-10	20201(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY macrophage|dobj|expression macrophage|nsubj|up-regulates up-regulates|amod|END_ENTITY	Il-10 up-regulates macrophage expression of the S100 protein S100A8 .
24663337	0	S100A8	89,95	MMP7	84,88	S100A8	MMP7	6279	4316	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CXCL4-induced plaque macrophages can be specifically identified by co-expression of MMP7 + S100A8 + in vitro and in vivo .
21472666	0	S100A8	54,60	THP-1	81,86	S100A8	THP-1	6279	2736	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	RAGE-dependent regulation of calcium-binding proteins S100A8 and S100A9 in human THP-1 .
23800059	0	S100A8	26,32	TNFa	0,4	S100A8	TNFa	6279	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNFa - and IL-17A-mediated S100A8 expression is regulated by p38 MAPK .
18784990	0	S100A9	15,21	Calgranulin_B	0,13	S100A9	Calgranulin B	6280	6280	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Calgranulin_B -LRB- S100A9 -RRB- levels in bronchoalveolar lavage fluid of patients with interstitial_lung_diseases .
26431492	0	S100A9	157,163	Chitinase_3-like_1	0,18	S100A9	Chitinase 3-like 1	20202(Tax:10090)	12654(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY induces|advcl|regulating induces|nsubj|END_ENTITY	Chitinase_3-like_1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated_cancer by regulating S100A9 .
23135911	0	S100A9	0,6	EMMPRIN	28,35	S100A9	EMMPRIN	20202(Tax:10090)	12215(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	S100A9 is a novel ligand of EMMPRIN that promotes melanoma metastasis .
25907296	0	S100A9	0,6	ERK1/2	94,100	S100A9	ERK1/2	6280	5595;5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	S100A9 promotes human hepatocellular_carcinoma cell growth and invasion through RAGE-mediated ERK1/2 and p38 MAPK pathways .
22962574	0	S100A9	22,28	Interleukin-6	0,13	S100A9	Interleukin-6	6280	3569	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative_colitis .
12640137	0	S100A9	33,39	MRP-14	25,31	S100A9	MRP-14	20202(Tax:10090)	20202(Tax:10090)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Myeloid cell function in MRP-14 -LRB- S100A9 -RRB- null mice .
10632726	0	S100A9	43,49	MRP14	51,56	S100A9	MRP14	20202(Tax:10090)	20202(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Biochemical characterization of the murine S100A9 -LRB- MRP14 -RRB- protein suggests that it is functionally equivalent to its human counterpart despite its low degree of sequence homology .
23340902	0	S100A9	55,61	RAGE	34,38	S100A9	RAGE	6280	101669765	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of RAGE and its ligand -LRB- S100A9 -RRB- in cervical_lesions .
22470535	0	S100A9	0,6	TLR4	24,28	S100A9	TLR4	20202(Tax:10090)	21898(Tax:10090)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	S100A9 interaction with TLR4 promotes tumor growth .
16082188	0	S100A9	38,44	calgranulin-B	23,36	S100A9	calgranulin-B	6280	6280	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Psoriasin -LRB- S100A7 -RRB- and calgranulin-B -LRB- S100A9 -RRB- induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants .
19534726	0	S100A9	25,31	p53	8,11	S100A9	p53	6280	7157	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel p53 target gene , S100A9 , induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway .
11312263	0	S100B	79,84	AHNAK	18,23	S100B	AHNAK	25742(Tax:10116)	191572(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY target|nmod|protein target|nsubj|END_ENTITY	The giant protein AHNAK is a specific target for the calcium - and zinc-binding S100B protein : potential implications for Ca2 + homeostasis regulation by S100B .
20351179	0	S100B	42,47	ATAD3A	150,156	S100B	ATAD3A	6285	55210	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A .
22542587	0	S100B	89,94	ATAD3A	60,66	S100B	ATAD3A	6285	55210	Gene	Gene	target|nmod|START_ENTITY production|appos|target production|nmod|END_ENTITY	Yeast-based production and purification of HIS-tagged human ATAD3A , A specific target of S100B .
17023559	0	S100B	0,5	COX-2	46,51	S100B	COX-2	6285	4513	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	S100B binding to RAGE in microglia stimulates COX-2 expression .
10757524	0	S100B	14,19	ERK	38,41	S100B	ERK	6285	5594	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Extracellular S100B protein modulates ERK in astrocyte cultures .
26204512	0	S100B	0,5	IL1b	44,48	S100B	IL1b	20203(Tax:10090)	16176(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	S100B Up-Regulates Macrophage Production of IL1b and CCL22 and Influences Severity of Retinal Inflammation .
26204512	0	S100B	0,5	IL1b	44,48	S100B	IL1b	20203(Tax:10090)	16176(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	S100B Up-Regulates Macrophage Production of IL1b and CCL22 and Influences Severity of Retinal Inflammation .
22025532	0	S100B	143,148	RAGE	130,134	S100B	RAGE	6285	101669765	Gene	Gene	ligand|appos|START_ENTITY ligand|amod|END_ENTITY	Human eosinophils express RAGE , produce RAGE ligands , exhibit PKC-delta phosphorylation and enhanced viability in response to the RAGE ligand , S100B .
21371524	0	S100B	20,25	aquaporin-4	61,72	S100B	aquaporin-4	6285	361	Gene	Gene	Usefulness|nmod|START_ENTITY Usefulness|nmod|autoimmune_syndrome autoimmune_syndrome|amod|END_ENTITY	Usefulness of serum S100B as a marker for the acute phase of aquaporin-4 autoimmune_syndrome .
23142267	0	S100B	49,54	aquaporin-4	27,38	S100B	aquaporin-4	25742(Tax:10116)	25293(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Non-specific inhibitors of aquaporin-4 stimulate S100B secretion in acute hippocampal slices of rats .
20505289	0	S100B	52,57	erythropoietin	28,42	S100B	erythropoietin	6285	2056	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of recombinant human erythropoietin on serum S100B protein and interleukin-6 levels after traumatic_brain_injury in the rat .
23786666	0	S100B	131,136	neurospecific_enolase	97,118	S100B	neurospecific enolase	25742(Tax:10116)	24334(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- An experimental model of mass-type brain_damage in the rat : expression of brain_damage based on neurospecific_enolase and protein S100B -RSB- .
20587415	0	S100B	28,33	p53	49,52	S100B	p53	6285	7157	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant_melanoma .
26797416	0	S100P	122,127	LASP-1	0,6	S100P	LASP-1	6286	3927	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	LASP-1 induces proliferation , metastasis and cell cycle arrest at the G2/M phase in gallbladder_cancer by down-regulating S100P via the PI3K/AKT pathway .
17587138	0	S100P	19,24	RAGE	0,4	S100P	RAGE	6286	101669765	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	RAGE activation by S100P in colon_cancer stimulates growth , migration , and cell signaling pathways .
15632002	0	S100P	14,19	S100PBPR	50,58	S100P	S100PBPR	6286	64766	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of S100P and its novel binding partner S100PBPR in early pancreatic_cancer .
19018761	0	S100P	42,47	bone_morphogenetic_protein	64,90	S100P	bone morphogenetic protein	6286	649	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of the calcium-binding protein S100P is regulated by bone_morphogenetic_protein in pancreatic duct epithelial cell lines .
15632002	0	S100PBPR	50,58	S100P	14,19	S100PBPR	S100P	64766	6286	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of S100P and its novel binding partner S100PBPR in early pancreatic_cancer .
7808229	0	S100_beta	91,100	GAP-43	81,87	S100 beta	GAP-43	6285	2596	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of protein_kinase_C - and casein_kinase_II-mediated phosphorylation of GAP-43 by S100_beta .
25311085	0	S100_calcium_binding_protein_A4	94,125	Hotair	52,58	S100 calcium binding protein A4	Hotair	6275	100124700	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Nuclear_factor_of_activated_T_cells_5 maintained by Hotair suppression of miR-568 upregulates S100_calcium_binding_protein_A4 to promote breast_cancer metastasis .
26438270	0	S100_calcium_binding_protein_A8	13,44	CD25	99,103	S100 calcium binding protein A8	CD25	6279	3669	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Up-regulated S100_calcium_binding_protein_A8 in Plasmodium-infected patients correlates with CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 regulatory T cell generation .
26899964	0	S100b	0,5	Myoglobin	28,37	S100b	Myoglobin	6285	4151	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	S100b induces expression of Myoglobin in APb treated neuronal cells in vitro : a possible neuroprotective mechanism .
23473361	0	S100b	14,19	neuron-specific_enolase	50,73	S100b	neuron-specific enolase	6285	2026	Gene	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	The impact of S100b and persistent high levels of neuron-specific_enolase on cognitive performance in elderly patients after cardiopulmonary bypass .
10762718	0	S100beta	0,8	PKA	73,76	S100beta	PKA	25742(Tax:10116)	25636(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	S100beta inhibits the phosphorylation of the L-MAG cytoplasmic domain by PKA .
22703031	0	S1166	5,10	EGFR	0,4	S1166	EGFR	1077562(Tax:198215)	1956	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	EGFR S1166 phosphorylation induced by a combination of EGF and gefitinib has a potentially negative impact on lung_cancer cell growth .
6773542	1	S13	73,76	L12	148,151	S13	L12	34149(Tax:7227)	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	L13	153,156	S13	L13	34149(Tax:7227)	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	L16	158,161	S13	L16	34149(Tax:7227)	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	L18	163,166	S13	L18	34149(Tax:7227)	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	L19	168,171	S13	L19	34149(Tax:7227)	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	S14	78,81	S13	S14	34149(Tax:7227)	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	S16	83,86	S13	S16	34149(Tax:7227)	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	S19	88,91	S13	S19	34149(Tax:7227)	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S13	73,76	S24	111,114	S13	S24	34149(Tax:7227)	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
10738947	0	S1319	15,20	beta2-adrenoceptor	52,70	S1319	beta2-adrenoceptor	1077695(Tax:198215)	154	Gene	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	The effects of S1319 , a novel marine sponge-derived beta2-adrenoceptor agonist , on IgE-mediated activation of human cultured mast cells .
24610576	0	S1379	99,104	ROCK2	124,129	S1379	ROCK2	1077743(Tax:198215)	9475	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Prostaglandin_E -LRB- 2 -RRB- - dependent blockade of actomyosin and stress fibre formation is mediated through S1379 phosphorylation of ROCK2 .
6773542	1	S14	78,81	L12	148,151	S14	L12	117414(Tax:7227)	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S14	78,81	L13	153,156	S14	L13	117414(Tax:7227)	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S14	78,81	L16	158,161	S14	L16	117414(Tax:7227)	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S14	78,81	L18	163,166	S14	L18	117414(Tax:7227)	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S14	78,81	L19	168,171	S14	L19	117414(Tax:7227)	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
8663275	0	S14	66,69	Peroxisome_proliferator-activated_receptor_alpha	0,48	S14	Peroxisome proliferator-activated receptor alpha	25357(Tax:10116)	25747(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha inhibits hepatic S14 gene transcription .
6773542	1	S14	78,81	S13	73,76	S14	S13	117414(Tax:7227)	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
2584193	0	S14	22,25	S14	85,88	S14	S14	25357(Tax:10116)	25357(Tax:10116)	Gene	Gene	START_ENTITY|nmod|that that|nmod|END_ENTITY	Identification of rat S14 protein and comparison of its regulation with that of mRNA S14 employing synthetic peptide antisera .
2584193	0	S14	85,88	S14	22,25	S14	S14	25357(Tax:10116)	25357(Tax:10116)	Gene	Gene	that|nmod|START_ENTITY END_ENTITY|nmod|that	Identification of rat S14 protein and comparison of its regulation with that of mRNA S14 employing synthetic peptide antisera .
6773542	1	S14	78,81	S16	83,86	S14	S16	117414(Tax:7227)	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S14	78,81	S19	88,91	S14	S19	117414(Tax:7227)	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S14	78,81	S24	111,114	S14	S24	117414(Tax:7227)	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
23775087	0	S14	18,21	c-Myc	43,48	S14	c-Myc	6208	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Ribosomal protein S14 negatively regulates c-Myc activity .
6773542	1	S16	83,86	L12	148,151	S16	L12	39001(Tax:7227)	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S16	83,86	L13	153,156	S16	L13	39001(Tax:7227)	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S16	83,86	L16	158,161	S16	L16	39001(Tax:7227)	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S16	83,86	L18	163,166	S16	L18	39001(Tax:7227)	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S16	83,86	L19	168,171	S16	L19	39001(Tax:7227)	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
11121577	0	S16	18,21	S10	13,16	S16	S10	6217	6204	Gene	Gene	Proteins|nummod|START_ENTITY Proteins|nummod|END_ENTITY	Proteins S7 , S10 , S16 and S19 of the human 40S ribosomal subunit are most resistant to dissociation by salt .
6773542	1	S16	83,86	S13	73,76	S16	S13	39001(Tax:7227)	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S16	83,86	S14	78,81	S16	S14	39001(Tax:7227)	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S16	83,86	S19	88,91	S16	S19	39001(Tax:7227)	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S16	83,86	S24	111,114	S16	S24	39001(Tax:7227)	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
7550356	0	S182	35,39	presenilin_1	21,33	S182	presenilin 1	5663	5663	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The structure of the presenilin_1 -LRB- S182 -RRB- gene and identification of six novel mutations in early onset AD families .
6773542	1	S19	88,91	L12	148,151	S19	L12	39000(Tax:7227)	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	L13	153,156	S19	L13	39000(Tax:7227)	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	L16	158,161	S19	L16	39000(Tax:7227)	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	L18	163,166	S19	L18	39000(Tax:7227)	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	L19	168,171	S19	L19	39000(Tax:7227)	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	S13	73,76	S19	S13	39000(Tax:7227)	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	S14	78,81	S19	S14	39000(Tax:7227)	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	S16	83,86	S19	S16	39000(Tax:7227)	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S19	88,91	S24	111,114	S19	S24	39000(Tax:7227)	37589(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
26875984	0	S1P	44,47	Site_1_Protease	27,42	S1P	Site 1 Protease	8720	8720	Gene	Gene	Inhibitor|appos|START_ENTITY Inhibitor|compound|END_ENTITY	Suppressive Effects of the Site_1_Protease -LRB- S1P -RRB- Inhibitor , PF-429242 , on Dengue_Virus_Propagation .
18424450	0	S1P	21,24	Sphingosine_kinase_1	0,20	S1P	Sphingosine kinase 1	13609(Tax:10090)	20698(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY controls|nsubj|axis END_ENTITY|parataxis|controls	Sphingosine_kinase_1 / S1P receptor signaling axis controls glial proliferation in mice with Sandhoff_disease .
10944850	0	S1P	72,75	site-1_protease	55,70	S1P	site-1 protease	8720	8720	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and chromosomal mapping of the human site-1_protease -LRB- S1P -RRB- gene .
20068174	0	S1P	0,3	sphingosine-1-phosphate	43,66	S1P	sphingosine-1-phosphate	13609(Tax:10090)	13609(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	S1P -LRB- 2 -RRB- , the G protein-coupled receptor for sphingosine-1-phosphate , negatively regulates tumor angiogenesis and tumor growth in vivo in mice .
22067914	0	S1P1	10,14	AP-1	33,37	S1P1	AP-1	13609(Tax:10090)	16476(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	CCR7 with S1P1 signaling through AP-1 for migration of Foxp3 + regulatory T-cells controls autoimmune exocrinopathy .
14688232	0	S1P1	123,127	Edg-1	117,122	S1P1	Edg-1	1901	1901	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1 / S1P1 receptor .
25718342	1	S1P1	57,61	RPC1063	36,43	S1P1	RPC1063	1901	3969634(Tax:316056)	Gene	Gene	Properties|appos|START_ENTITY Properties|nmod|END_ENTITY	Pharmacokinetic Properties of RPC1063 , a Selective S1P1 and S1P5 Receptor Agonist , Significantly Contribute to Efficacy in Animal Models of Inflammatory_Bowel_Disease .
24903384	0	S1P1	54,58	S1P2	60,64	S1P1	S1P2	1901	9294	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	The role of sphingosine kinase isoforms and receptors S1P1 , S1P2 , S1P3 , and S1P5 in primary , secondary , and recurrent glioblastomas .
24903384	0	S1P1	54,58	S1P3	66,70	S1P1	S1P3	1901	1903	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	The role of sphingosine kinase isoforms and receptors S1P1 , S1P2 , S1P3 , and S1P5 in primary , secondary , and recurrent glioblastomas .
18773427	0	S1P1	13,17	bFGF	0,4	S1P1	bFGF	1901	2247	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	bFGF induces S1P1 receptor expression and functionality in human pulmonary artery smooth muscle cells .
16682185	0	S1P1	67,71	sphingosine-1-phosphate_1	40,65	S1P1	sphingosine-1-phosphate 1	1901	1901	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Highly selective and potent agonists of sphingosine-1-phosphate_1 -LRB- S1P1 -RRB- receptor .
25890801	0	S1P1	78,82	sphingosine_1-phosphate_receptor_1	42,76	S1P1	sphingosine 1-phosphate receptor 1	29733(Tax:10116)	29733(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of heterocyclic_sulfonamides as sphingosine_1-phosphate_receptor_1 -LRB- S1P1 -RRB- antagonists .
26130058	0	S1P1	53,57	sphingosine_1_phosphate_receptor-1	17,51	S1P1	sphingosine 1 phosphate receptor-1	1901	1901	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Dysregulation of sphingosine_1_phosphate_receptor-1 -LRB- S1P1 -RRB- signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS rebound .
24903384	0	S1P2	60,64	S1P1	54,58	S1P2	S1P1	9294	1901	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	The role of sphingosine kinase isoforms and receptors S1P1 , S1P2 , S1P3 , and S1P5 in primary , secondary , and recurrent glioblastomas .
24903384	0	S1P2	60,64	S1P3	66,70	S1P2	S1P3	9294	1903	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	The role of sphingosine kinase isoforms and receptors S1P1 , S1P2 , S1P3 , and S1P5 in primary , secondary , and recurrent glioblastomas .
26116468	0	S1P3	24,28	LYVE-1	34,40	S1P3	LYVE-1	1903	10894	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The cooperative role of S1P3 with LYVE-1 in LMW-HA-induced lymphangiogenesis .
24903384	0	S1P3	66,70	S1P1	54,58	S1P3	S1P1	1903	1901	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	The role of sphingosine kinase isoforms and receptors S1P1 , S1P2 , S1P3 , and S1P5 in primary , secondary , and recurrent glioblastomas .
24903384	0	S1P3	66,70	S1P2	60,64	S1P3	S1P2	1903	9294	Gene	Gene	receptors|nummod|START_ENTITY receptors|nummod|END_ENTITY	The role of sphingosine kinase isoforms and receptors S1P1 , S1P2 , S1P3 , and S1P5 in primary , secondary , and recurrent glioblastomas .
26321412	0	S1PR1	68,73	IL-8	34,38	S1PR1	IL-8	1901	3576	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Sphingosine_1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8 / SVneo cells .
26238015	0	S1PR1	36,41	Sphingosine-1-phosphate_receptor_1	0,34	S1PR1	Sphingosine-1-phosphate receptor 1	1901	1901	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sphingosine-1-phosphate_receptor_1 -LRB- S1PR1 -RRB- expression in non-muscle_invasive_urothelial_carcinoma : Association with poor clinical outcome and potential therapeutic target .
24453941	0	S1PR2	26,31	Nogo-a	50,56	S1PR2	Nogo-a	14739(Tax:10090)	68585(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity .
23723450	0	S1PR2	53,58	sphingosine-1-phosphate_receptor_2	17,51	S1PR2	sphingosine-1-phosphate receptor 2	9294	9294	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of sphingosine-1-phosphate_receptor_2 -LRB- S1PR2 -RRB- in acute vascular_inflammation .
22326262	0	S1P_receptor_1	30,44	receptor_activator_of_NF-kB_ligand	65,99	S1P receptor 1	receptor activator of NF-kB ligand	1901	8600	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- / S1P_receptor_1 signaling regulates receptor_activator_of_NF-kB_ligand -LRB- RANKL -RRB- expression in rheumatoid_arthritis .
24064301	0	S1P_receptor_2	78,92	COX-2	38,43	S1P receptor 2	COX-2	29415(Tax:10116)	26198(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- induces COX-2 expression and PGE2 formation via S1P_receptor_2 in renal_mesangial_cells .
25363242	0	S1P_receptor_2	31,45	sphingosine_kinase_2	68,88	S1P receptor 2	sphingosine kinase 2	14739(Tax:10090)	56632(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Conjugated bile_acid-activated S1P_receptor_2 is a key regulator of sphingosine_kinase_2 and hepatic gene expression .
6773542	1	S24	111,114	L12	148,151	S24	L12	37589(Tax:7227)	46003	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	L13	153,156	S24	L13	37589(Tax:7227)	249394	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	L16	158,161	S24	L16	37589(Tax:7227)	5657033	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	L18	163,166	S24	L18	37589(Tax:7227)	251730	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	L19	168,171	S24	L19	37589(Tax:7227)	247160	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	S13	73,76	S24	S13	37589(Tax:7227)	34149(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	S14	78,81	S24	S14	37589(Tax:7227)	117414(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	S16	83,86	S24	S16	37589(Tax:7227)	39001(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
6773542	1	S24	111,114	S19	88,91	S24	S19	37589(Tax:7227)	39000(Tax:7227)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Isolation of proteins S8 , S13 , S14 , S16 , S19 , S20/L24 , S22/L26 , S24 , S25/S27 , S26 , S29 , L4 , L10/L11 , L12 , L13 , L16 , L18 , L19 , L27 , 1 , 7/8 , 9 , and 11 .
8001977	0	S31	63,66	5-HT1E	36,42	S31	5-HT1E	3354	3354	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
8001977	0	S31	63,66	HTR1E	75,80	S31	HTR1E	3354	3354	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Assignment of the gene encoding the 5-HT1E serotonin receptor -LRB- S31 -RRB- -LRB- locus HTR1E -RRB- to human chromosome 6q14-q15 .
11737601	0	S3226	0,5	NHE3	15,19	S3226	NHE3	1079480(Tax:198215)	24784(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	S3226 , a novel NHE3 inhibitor , attenuates ischemia-induced acute_renal_failure in rats .
26191232	0	S4646	0,5	CYP19A1	22,29	S4646	CYP19A1	1080844(Tax:198215)	1588	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	S4646 polymorphism in CYP19A1 gene is associated with the efficacy of hormone therapy in early breast_cancer .
16171779	0	S5a	48,51	NUB1	15,19	S5a	NUB1	5710	51667	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of NUB1 with the proteasome subunit S5a .
24829148	0	S5a	0,3	death_receptor-6	13,29	S5a	death receptor-6	5710	27242	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	S5a binds to death_receptor-6 to induce THP-1 monocytes to differentiate through the activation of the NF-kB pathway .
12766775	0	S6K	34,37	Rheb	0,4	S6K	Rheb	38654(Tax:7227)	117332(Tax:7227)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Rheb is an essential regulator of S6K in controlling cell growth in Drosophila .
14653992	0	S6K1	63,67	Cdc42	43,48	S6K1	Cdc42	6198	998	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1 .
21289241	0	S6K1	22,26	IRS1	55,59	S6K1	IRS1	6198	3667	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired_glucose_tolerance_postpartum .
20657550	0	S6K1	0,4	Mdm2	36,40	S6K1	Mdm2	6198	4193	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response .
15475011	0	S6K1	46,50	Rac1	27,31	S6K1	Rac1	83840(Tax:10116)	363875(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Hydrogen_peroxide mediates Rac1 activation of S6K1 .
19720745	0	S6K1	96,100	Rictor	20,26	S6K1	Rictor	6198	253260	Gene	Gene	complex|nmod|START_ENTITY reveals|xcomp|complex reveals|nsubj|Characterization Characterization|nmod|sites sites|compound|END_ENTITY	Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1 .
19995915	0	S6K1	17,21	Rictor	37,43	S6K1	Rictor	6198	253260	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling .
12429015	0	S6K1	14,18	S6_kinase_1	42,53	S6K1	S6 kinase 1	6198	6198	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of S6K1 -LRB- p70 ribosomal protein S6_kinase_1 -RRB- requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex .
21806970	0	S6K1	8,12	SREBP1c	30,37	S6K1	SREBP1c	72508(Tax:10090)	20787(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of S6K1 in regulation of SREBP1c expression in the liver .
12658115	0	S6K1_and_4E-BP1	33,48	IGF-I	0,5	S6K1 and 4E-BP1	IGF-I	83840;116636	24482(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	IGF-I induced phosphorylation of S6K1_and_4E-BP1 in heart is impaired by acute_alcohol_intoxication .
15525759	0	S6KII	4,9	rsk	11,14	S6KII	rsk	33139(Tax:7227)	33139(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The S6KII -LRB- rsk -RRB- gene of Drosophila_melanogaster differentially affects an operant and a classical learning task .
11478495	0	S6_kinase	37,46	Cholecystokinin	0,15	S6 kinase	Cholecystokinin	83840(Tax:10116)	25298(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Cholecystokinin activation of 70-kDa S6_kinase in exocrine pancreas .
2281080	0	S6_kinase	48,57	Cholecystokinin	0,15	S6 kinase	Cholecystokinin	83840(Tax:10116)	25298(Tax:10116)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Cholecystokinin stimulates a specific ribosomal S6_kinase in rat pancreatic acini .
2848828	0	S6_kinase	3,12	S6_kinase	86,95	S6 kinase	S6 kinase	83840(Tax:10116)	83840(Tax:10116)	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	An S6_kinase activated during liver regeneration is related to the insulin-stimulated S6_kinase in H4 hepatoma cells .
2848828	0	S6_kinase	86,95	S6_kinase	3,12	S6 kinase	S6 kinase	83840(Tax:10116)	83840(Tax:10116)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	An S6_kinase activated during liver regeneration is related to the insulin-stimulated S6_kinase in H4 hepatoma cells .
16611854	0	S6_kinase-1	144,155	p70	130,133	S6 kinase-1	p70	6198	84959	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma and retinoic_acid_X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6_kinase-1 inhibition : role for Zf9 dephosphorylation .
23627466	0	S6_kinase-1	106,117	p70	92,95	S6 kinase-1	p70	72508(Tax:10090)	16185(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6_kinase-1 inhibition in high-fat-high-fructose diet-fed mice .
12429015	0	S6_kinase_1	42,53	S6K1	14,18	S6 kinase 1	S6K1	6198	6198	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of S6K1 -LRB- p70 ribosomal protein S6_kinase_1 -RRB- requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex .
19112174	0	S6_kinase_1	0,11	estrogen_receptor_alpha	22,45	S6 kinase 1	estrogen receptor alpha	6198	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	S6_kinase_1 regulates estrogen_receptor_alpha in control of breast_cancer cell proliferation .
11134159	0	S6k	46,49	p70	42,45	S6k	p70	6198	309	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Physiological hyperinsulinemia stimulates p70 -LRB- S6k -RRB- phosphorylation in human skeletal muscle .
11170836	0	S6k	33,36	p70	29,32	S6k	p70	6198	309	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Autocrine phosphorylation of p70 -LRB- S6k -RRB- in response to acute stretch in myotubes .
22121809	0	SA-B	31,35	salviandic_acid_B	12,29	SA-B	salviandic acid B	117186(Tax:10116)	117186(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of salviandic_acid_B -LRB- SA-B -RRB- on activity of basement membrane-type collagenase and impact of regulatory factors in rats with cardiac_hypertrophy -RSB- .
1292638	0	SAA	28,31	IL-1_receptor_antagonist	84,108	SAA	IL-1 receptor antagonist	111345(Tax:10090)	16181(Tax:10090)	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Suppression of IL-2-induced SAA gene expression in mice by the administration of an IL-1_receptor_antagonist .
2001421	0	SAA	138,141	IL-6	63,67	SAA	IL-6	6287	3569	Gene	Gene	C-reactive_protein|appos|START_ENTITY synthesis|nmod|C-reactive_protein stimulated|dobj|synthesis interleukin|acl|stimulated interleukin|amod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- inhibits interleukin -LRB- IL -RRB- -1 and/or IL-6 stimulated synthesis of C-reactive_protein -LRB- CRP -RRB- and serum_amyloid_A -LRB- SAA -RRB- in primary cultures of human hepatocytes .
7790046	0	SAA	43,46	IL-6	51,55	SAA	IL-6	6287	3569	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of serum_amyloid_A -LRB- SAA -RRB- by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line .
21465531	0	SAA	56,59	PTX3	0,4	SAA	PTX3	6287	5806	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	PTX3 , a key component of innate immunity , is induced by SAA via FPRL1-mediated signaling in HAECs .
22447522	0	SAA	17,20	PTX3	43,47	SAA	PTX3	6287	5806	Gene	Gene	Serum_amyloid_A|appos|START_ENTITY induces|nsubj|Serum_amyloid_A induces|dobj|production production|appos|END_ENTITY	Serum_amyloid_A -LRB- SAA -RRB- induces pentraxin_3 -LRB- PTX3 -RRB- production in rheumatoid_synoviocytes .
63517	0	SAA	30,33	SAA	83,86	SAA	SAA	6287	6287	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Amyloid-related serum protein SAA from three animal species : comparison with human SAA .
63517	0	SAA	83,86	SAA	30,33	SAA	SAA	6287	6287	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Amyloid-related serum protein SAA from three animal species : comparison with human SAA .
20840651	0	SAA	52,55	p19	28,31	SAA	p19	6287	51561	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of interleukin-23 p19 by serum_amyloid_A -LRB- SAA -RRB- in rheumatoid_synoviocytes .
10487231	0	SAA	50,53	serum_amyloid_A	33,48	SAA	serum amyloid A	6287	6287	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of recombinant feline serum_amyloid_A -LRB- SAA -RRB- protein .
11298127	0	SAA	41,44	serum_amyloid_A	24,39	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Impaired degradation of serum_amyloid_A -LRB- SAA -RRB- protein by cytokine-stimulated monocytes .
12736442	0	SAA	38,41	serum_amyloid_A	21,36	SAA	serum amyloid A	678660(Tax:9685)	678660(Tax:9685)	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of feline serum_amyloid_A -LRB- SAA -RRB- as an inflammatory marker .
12874643	0	SAA	38,41	serum_amyloid_A	21,36	SAA	serum amyloid A	6287	6287	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	-LSB- Association between serum_amyloid_A -LRB- SAA -RRB- in salivary glands and high levels of circulating beta_2-microglobulin in patients with Sj gren syndrome -RSB- .
1720442	0	SAA	64,67	serum_amyloid_A	47,62	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	A monoclonal antibody sandwich immunoassay for serum_amyloid_A -LRB- SAA -RRB- protein .
1995703	0	SAA	54,57	serum_amyloid_A	37,52	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	A solid phase enzyme immunoassay for serum_amyloid_A -LRB- SAA -RRB- protein .
20075072	0	SAA	33,36	serum_amyloid_A	16,31	SAA	serum amyloid A	6287	6287	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	CD36 is a novel serum_amyloid_A -LRB- SAA -RRB- receptor mediating SAA binding and SAA-induced signaling in human and rodent cells .
2017667	0	SAA	57,60	serum_amyloid_A	40,55	SAA	serum amyloid A	6287	6287	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Highly polymorphic domains of the human serum_amyloid_A -LRB- SAA -RRB- gene GSAA1 .
2502829	0	SAA	49,52	serum_amyloid_A	32,47	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The primary structure of equine serum_amyloid_A -LRB- SAA -RRB- protein .
3423742	0	SAA	44,47	serum_amyloid_A	27,42	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The amino_acid sequence of serum_amyloid_A -LRB- SAA -RRB- protein in mink .
7769239	0	SAA	73,76	serum_amyloid_A	56,71	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Quantification and mapping of antigenic determinants of serum_amyloid_A -LRB- SAA -RRB- protein utilizing sequence-specific immunoglobulins and Eu3 + as a specific probe for time-resolved fluorometric immunoassay .
7790046	0	SAA	43,46	serum_amyloid_A	26,41	SAA	serum amyloid A	6287	6287	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of serum_amyloid_A -LRB- SAA -RRB- by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line .
7851899	0	SAA	111,114	serum_amyloid_A	94,109	SAA	serum amyloid A	6287	6287	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Use of somatic cell hybrids and fluorescence in situ hybridization to localize the functional serum_amyloid_A -LRB- SAA -RRB- genes to chromosome 11p15.4-p15 .1 and the entire SAA superfamily to chromosome 11p15 .
8188253	0	SAA	34,37	serum_amyloid_A	17,32	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Evolution of the serum_amyloid_A -LRB- SAA -RRB- protein superfamily .
8316768	0	SAA	52,55	serum_amyloid_A	35,50	SAA	serum amyloid A	6287	6287	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The revised amino_acid sequence of serum_amyloid_A -LRB- SAA -RRB- protein in mink .
9360966	0	SAA	30,33	serum_amyloid_A	13,28	SAA	serum amyloid A	6287	6287	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Induction of serum_amyloid_A -LRB- SAA -RRB- gene by SAA-activating sequence-binding factor -LRB- SAF -RRB- in monocyte/macrophage cells .
9472687	0	SAA	23,26	serum_amyloid_A	6,21	SAA	serum amyloid A	111345(Tax:10090)	111345(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Mouse serum_amyloid_A -LRB- SAA -RRB- proteins isolated by two-dimensional electrophoresis : characterization of isotypes and the effect of separate and combined administrations of cytokines , dexamethasone and lipopolysaccharide -LRB- LPS -RRB- on serum levels and isotype distribution .
4086942	0	SAA	36,39	serum_amyloid_A_protein	11,34	SAA	serum amyloid A protein	6288	6288	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of serum_amyloid_A_protein -LRB- SAA -RRB- on composition , size , and density of high density lipoproteins in subjects with myocardial_infarction .
428149	0	SAA	39,42	serum_amyloid_A_protein	14,37	SAA	serum amyloid A protein	6288	6288	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of the serum_amyloid_A_protein -LRB- SAA -RRB- in normal persons of different age groups .
6467904	0	SAA	48,51	serum_amyloid_a_protein	23,46	SAA	serum amyloid a protein	6288	6288	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A comparative study of serum_amyloid_a_protein -LRB- SAA -RRB- from mink and man .
7686132	0	SAA2	171,175	serum_amyloid_A	141,156	SAA2	serum amyloid A	6289	6287	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A constitutively expressed serum_amyloid_A protein gene -LRB- SAA4 -RRB- is closely linked to , and shares structural similarities with , an acute-phase serum_amyloid_A protein gene -LRB- SAA2 -RRB- .
25738827	0	SAA3	24,28	Serum_Amyloid_A3	6,22	SAA3	Serum Amyloid A3	6290	6290	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	Human Serum_Amyloid_A3 -LRB- SAA3 -RRB- Protein , Expressed as a Fusion Protein with SAA2 , Binds the Oxidized Low Density Lipoprotein Receptor .
18452164	0	SAA3	14,18	interleukin-1beta	33,50	SAA3	interleukin-1beta	20210(Tax:10090)	16176(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes .
1755958	0	SAA3	50,54	serum_amyloid_A	27,42	SAA3	serum amyloid A	6290	6287	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Nonexpression of the human serum_amyloid_A three -LRB- SAA3 -RRB- gene .
19513118	0	SAA3	32,36	serum_amyloid_A3	14,30	SAA3	serum amyloid A3	20210(Tax:10090)	20210(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of serum_amyloid_A3 -LRB- SAA3 -RRB- in mouse colonic epithelium and adipose tissue by the intestinal microbiota .
7686132	0	SAA4	57,61	serum_amyloid_A	27,42	SAA4	serum amyloid A	6291	6287	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A constitutively expressed serum_amyloid_A protein gene -LRB- SAA4 -RRB- is closely linked to , and shares structural similarities with , an acute-phase serum_amyloid_A protein gene -LRB- SAA2 -RRB- .
7775864	0	SAA4	64,68	serum_amyloid_A_protein	39,62	SAA4	serum amyloid A protein	6291	6291	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of constitutive human serum_amyloid_A_protein -LRB- SAA4 -RRB- as an apolipoprotein .
22162999	0	SAF-A	0,5	BRG1	27,31	SAF-A	BRG1	3192	6597	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription .
11530285	0	SAF-A	66,71	heterogeneous_nuclear_ribonucleoprotein_U	15,56	SAF-A	heterogeneous nuclear ribonucleoprotein U	51810(Tax:10090)	51810(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of the heterogeneous_nuclear_ribonucleoprotein_U -LRB- hnRNP_U / SAF-A -RRB- on glucocorticoid-dependent transcription in vivo .
9405365	0	SAF-A	62,67	scaffold_attachment_factor_A	32,60	SAF-A	scaffold attachment factor A	3192	3192	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The novel SAR-binding domain of scaffold_attachment_factor_A -LRB- SAF-A -RRB- is a target in apoptotic nuclear breakdown .
16195251	0	SAFB1	27,32	nuclear_receptor_corepressor	120,148	SAFB1	nuclear receptor corepressor	6294	9611	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Scaffold attachment factor SAFB1 suppresses estrogen_receptor_alpha-mediated transcription in part via interaction with nuclear_receptor_corepressor .
24331460	0	SAG101	76,82	EDS1	44,48	SAG101	EDS1	831345(Tax:3702)	823964(Tax:3702)	Gene	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Structural basis for signaling by exclusive EDS1 heteromeric complexes with SAG101 or PAD4 in plant innate immunity .
19581335	0	SAL-Like_4	23,33	SALL4	35,40	SAL-Like 4	SALL4	57167	57167	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Mutational analysis of SAL-Like_4 -LRB- SALL4 -RRB- in Han Chinese women with premature_ovarian_failure .
19619907	0	SAL-Like_4	21,31	SALL4	33,38	SAL-Like 4	SALL4	57167	57167	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic variation of SAL-Like_4 -LRB- SALL4 -RRB- in ventricular_septal_defect .
1474892	0	SAL4	35,39	SUP45	41,46	SAL4	SUP45	852440(Tax:4932)	852440(Tax:4932)	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Ribosomal association of the yeast SAL4 -LRB- SUP45 -RRB- gene product : implications for its role in translation fidelity and termination .
7586027	0	SAL4	30,34	SUP45	23,28	SAL4	SUP45	852440(Tax:4932)	852440(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A mutant allele of the SUP45 -LRB- SAL4 -RRB- gene of Saccharomyces_cerevisiae shows temperature-dependent allosuppressor and omnipotent suppressor phenotypes .
12200128	0	SALL1	43,48	UBE2I	54,59	SALL1	UBE2I	6299	7329	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1 .
19139273	0	SALL3	0,5	DNMT3A	21,27	SALL3	DNMT3A	27164	1788	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular_carcinoma .
17557835	0	SALL4	27,32	Bmi-1	0,5	SALL4	Bmi-1	99377(Tax:10090)	12151(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells .
20410807	0	SALL4	46,51	NANOG	59,64	SALL4	NANOG	57167	79923	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	SALL4	46,51	OCT4	53,57	SALL4	OCT4	57167	5460	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
19581335	0	SALL4	35,40	SAL-Like_4	23,33	SALL4	SAL-Like 4	57167	57167	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Mutational analysis of SAL-Like_4 -LRB- SALL4 -RRB- in Han Chinese women with premature_ovarian_failure .
19619907	0	SALL4	33,38	SAL-Like_4	21,31	SALL4	SAL-Like 4	57167	57167	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic variation of SAL-Like_4 -LRB- SALL4 -RRB- in ventricular_septal_defect .
20410807	0	SALL4	46,51	SOX2	66,70	SALL4	SOX2	57167	6657	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	SALL4	46,51	UTF1	72,76	SALL4	UTF1	57167	8433	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
26407074	0	SALL4	0,5	c-Myc	100,105	SALL4	c-Myc	57167	4609	Gene	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|END_ENTITY	SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer .
14693677	0	SAM68	0,5	angiotensin_II	30,44	SAM68	angiotensin II	117268(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	SAM68 : a downstream target of angiotensin_II signaling in vascular smooth muscle cells in genetic hypertension .
11032186	0	SAMDC	54,59	S-adenosylmethionine_decarboxylase	18,52	SAMDC	S-adenosylmethionine decarboxylase	380052(Tax:8355)	380052(Tax:8355)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of S-adenosylmethionine_decarboxylase -LRB- SAMDC -RRB- activates the maternal program of apoptosis shortly after MBT in Xenopus embryos .
7948879	0	SAMDC	60,65	S-adenosylmethionine_decarboxylase	24,58	SAMDC	S-adenosylmethionine decarboxylase	102601725	102601725	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterisation of the S-adenosylmethionine_decarboxylase -LRB- SAMDC -RRB- gene of potato .
22972397	0	SAMHD1	0,6	CD4	44,47	SAMHD1	CD4	25939	920	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|cells cells|amod|HIV-1_infection HIV-1_infection|nmod|T T|compound|END_ENTITY	SAMHD1 restricts HIV-1_infection in resting CD4 -LRB- + -RRB- T cells .
22972397	0	SAMHD1	0,6	CD4	44,47	SAMHD1	CD4	25939	920	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|cells cells|amod|HIV-1_infection HIV-1_infection|nmod|T T|compound|END_ENTITY	SAMHD1 restricts HIV-1_infection in resting CD4 -LRB- + -RRB- T cells .
23092122	0	SAMHD1	0,6	CD4	58,61	SAMHD1	CD4	25939	920	Gene	Gene	restricts|nsubj|START_ENTITY restricts|ccomp|reverse reverse|nmod|T-cells T-cells|compound|END_ENTITY	SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4 -LRB- + -RRB- T-cells .
23092122	0	SAMHD1	0,6	CD4	58,61	SAMHD1	CD4	25939	920	Gene	Gene	restricts|nsubj|START_ENTITY restricts|ccomp|reverse reverse|nmod|T-cells T-cells|compound|END_ENTITY	SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4 -LRB- + -RRB- T-cells .
23426363	0	SAMHD1	31,37	CD4	63,66	SAMHD1	CD4	25939	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Promoter methylation regulates SAMHD1 gene expression in human CD4 + T cells .
23426363	0	SAMHD1	31,37	CD4	63,66	SAMHD1	CD4	25939	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Promoter methylation regulates SAMHD1 gene expression in human CD4 + T cells .
25715102	0	SAMHD1	4,10	CD4	76,79	SAMHD1	CD4	25939	920	Gene	Gene	expression|compound|START_ENTITY renders|nsubj|expression renders|xcomp|susceptible susceptible|nsubj|cells cells|compound|END_ENTITY	Low SAMHD1 expression following T-cell activation and proliferation renders CD4 + T cells susceptible to HIV-1 .
25996507	0	SAMHD1	99,105	CD4	109,112	SAMHD1	CD4	709060(Tax:9544)	713807(Tax:9544)	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus_Macaques Suppresses SAMHD1 in CD4 + Memory T Cells .
23602554	0	SAMHD1	19,25	CDK1	39,43	SAMHD1	CDK1	25939	983	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
23602554	0	SAMHD1	19,25	CDK1	39,43	SAMHD1	CDK1	25939	983	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
25015816	0	SAMHD1	97,103	CDK2	73,77	SAMHD1	CDK2	25939	1017	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells .
25015816	0	SAMHD1	97,103	CDK2	73,77	SAMHD1	CDK2	25939	1017	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells .
26923586	0	SAMHD1	13,19	IL-7	0,4	SAMHD1	IL-7	25939	3574	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	IL-7 Induces SAMHD1 Phosphorylation in CD4 + T Lymphocytes , Improving Early Steps of HIV-1 Life Cycle .
25604658	0	SAMHD1	111,117	RNASEH2A	81,89	SAMHD1	RNASEH2A	25939	10535	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
25604658	0	SAMHD1	111,117	RNASEH2B	91,99	SAMHD1	RNASEH2B	25939	79621	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
25604658	0	SAMHD1	111,117	RNASEH2C	101,109	SAMHD1	RNASEH2C	25939	84153	Gene	Gene	ADAR|appos|START_ENTITY ADAR|appos|END_ENTITY	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 .
23602554	0	SAMHD1	19,25	cyclin_A2	29,38	SAMHD1	cyclin A2	25939	890	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
23602554	0	SAMHD1	19,25	cyclin_A2	29,38	SAMHD1	cyclin A2	25939	890	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
25423367	0	SAMHD1	55,61	eEF1A1	33,39	SAMHD1	eEF1A1	25939	1915	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The eukaryotic elongation factor eEF1A1 interacts with SAMHD1 .
25423367	0	SAMHD1	55,61	eEF1A1	33,39	SAMHD1	eEF1A1	25939	1915	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The eukaryotic elongation factor eEF1A1 interacts with SAMHD1 .
15685547	0	SAMP1/YitFc	63,74	peroxisome_proliferator-activated_receptor-gamma	11,59	SAMP1/YitFc	peroxisome proliferator-activated receptor-gamma	230917(Tax:10090)	19016(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Linkage to peroxisome_proliferator-activated_receptor-gamma in SAMP1/YitFc mice and in human Crohn 's _ disease .
17203072	0	SAND-1	23,29	RAB-7	47,52	SAND-1	RAB-7	177318(Tax:6239)	174834(Tax:6239)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|function function|compound|END_ENTITY	Caenorhabditis_elegans SAND-1 is essential for RAB-7 function in endosomal traffic .
19150402	0	SAP	0,3	CD22	13,17	SAP	CD22	4068	933	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux .
20146065	0	SAP	55,58	SLAM	0,4	SAP	SLAM	4068	6504	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	SLAM family receptors and the SLAM-associated_protein -LRB- SAP -RRB- modulate T cell functions .
11099315	0	SAP	126,129	SLAM_and_2B4	148,160	SAP	SLAM and 2B4	4068	6504;51744	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Potential pathways for regulation of NK and T cell responses : differential X-linked_lymphoproliferative_syndrome gene product SAP interactions with SLAM_and_2B4 .
19738428	0	SAP	33,36	SLAM_associated_protein	38,61	SAP	SLAM associated protein	4068	4068	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The apoptosis modulating role of SAP -LRB- SLAM_associated_protein -RRB- contributes to the symptomatology of the X_linked_lymphoproliferative_disease .
15378026	0	SAP	24,27	p53	10,13	SAP	p53	4068	7157	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Wild-type p53 activates SAP expression in lymphoid cells .
118839	0	SAP	38,41	serum_amyloid_P-component	11,36	SAP	serum amyloid P-component	325	325	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of serum_amyloid_P-component -LRB- SAP -RRB- by amyloid fibrils .
3143483	0	SAP	87,90	serum_amyloid_P-component	60,85	SAP	serum amyloid P-component	20219(Tax:10090)	20219(Tax:10090)	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Receptor-mediated binding of the acute-phase reactant mouse serum_amyloid_P-component -LRB- SAP -RRB- to macrophages .
4054960	0	SAP	33,36	serum_amyloid_P-component	6,31	SAP	serum amyloid P-component	20219(Tax:10090)	20219(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Mouse serum_amyloid_P-component -LRB- SAP -RRB- levels controlled by a locus on chromosome 1 .
6600258	2	SAP	83,86	serum_amyloid_P-component	56,81	SAP	serum amyloid P-component	20219(Tax:10090)	20219(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Strain dependence of serum_amyloid_P-component -LRB- SAP -RRB- levels and response to inflammation .
12837766	0	SAP-1	15,20	Lck	98,101	SAP-1	Lck	5794	3932	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of SAP-1 , a transmembrane-type protein-tyrosine phosphatase , with the tyrosine kinase Lck .
24261636	0	SAP-1	31,36	cystatin_S	70,80	SAP-1	cystatin S	5794	1472	Gene	Gene	START_ENTITY|dep|form form|nmod|END_ENTITY	Studies on the interactions of SAP-1 -LRB- an N-terminal truncated form of cystatin_S -RRB- with its binding partners by CD-spectroscopic and molecular docking methods .
3771578	0	SAP-2	62,67	sphingolipid_activator_protein-2	28,60	SAP-2	sphingolipid activator protein-2	2004	2004	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and processing of sphingolipid_activator_protein-2 -LRB- SAP-2 -RRB- in cultured human fibroblasts .
2109697	0	SAP-2	69,74	sphingolipid_activator_protein_2	35,67	SAP-2	sphingolipid activator protein 2	2004	2004	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of sphingolipid_activator_protein_2 -LRB- SAP-2 -RRB- in normal and SAP-deficient fibroblasts .
8654588	0	SAP1	21,25	SIN1	109,113	SAP1	SIN1	856771(Tax:4932)	856908(Tax:4932)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of yeast SAP1 , a novel member of the ` AAA ' ATPase family of proteins , with the chromatin protein SIN1 .
7851904	0	SAP1	21,25	SRF_accessory_protein_1	27,50	SAP1	SRF accessory protein 1	2005	2005	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping of the human SAP1 -LRB- SRF_accessory_protein_1 -RRB- gene and SAP2 , a gene encoding a related protein , to chromosomal bands 1q32 and 12q23 , respectively .
11252167	0	SAP155	71,77	Sf3b1	64,69	SAP155	Sf3b1	81898(Tax:10090)	81898(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning , genetic mapping , and expression of the mouse Sf3b1 -LRB- SAP155 -RRB- gene for the U2 snRNP component of spliceosome .
14680513	0	SAP30L	35,41	TGF-beta	0,8	SAP30L	TGF-beta	79685	7040	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-beta induces the expression of SAP30L , a novel nuclear protein .
11602354	0	SAP62	73,78	AMH	104,107	SAP62	AMH	8175	268	Gene	Gene	SF3A2|appos|START_ENTITY SF3A2|nmod|END_ENTITY	An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 -LRB- SAP62 -RRB- immediately upstream of AMH .
8541848	0	SAP62	37,42	AMH	77,80	SAP62	AMH	8175	268	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	The genes for a spliceosome protein -LRB- SAP62 -RRB- and the anti-M llerian hormone -LRB- AMH -RRB- are contiguous .
15325264	0	SAP90	72,77	CK2	15,18	SAP90	CK2	29495(Tax:10116)	81650(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Protein kinase CK2 in postsynaptic densities : phosphorylation of PSD-95 / SAP90 and NMDA receptor regulation .
10521598	0	SAP90	65,70	PSD-95	58,64	SAP90	PSD-95	1742	1742	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95 / SAP90 family .
10627592	0	SAP90	95,100	PSD-95	88,94	SAP90	PSD-95	1742	1742	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Neuronal inwardly rectifying K -LRB- + -RRB- channels differentially couple to PDZ proteins of the PSD-95 / SAP90 family .
9581761	0	SAP90	58,63	PSD-95	51,57	SAP90	PSD-95	1742	1742	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	SynGAP : a synaptic RasGAP that associates with the PSD-95 / SAP90 protein family .
15978582	0	SAP90	70,75	Semaphorin_4B	0,13	SAP90	Semaphorin 4B	1742	10509	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Semaphorin_4B interacts with the post-synaptic density protein PSD-95 / SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif .
11060025	0	SAP97	37,42	GKAP	54,58	SAP97	GKAP	1739	9229	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Intramolecular interactions regulate SAP97 binding to GKAP .
24567325	0	SAP97	87,92	GluA1	32,37	SAP97	GluA1	1739	2890	Gene	Gene	delivery|nmod|START_ENTITY delivery|nmod|receptors receptors|amod|END_ENTITY	Sequential delivery of synaptic GluA1 - and GluA4-containing AMPA receptors -LRB- AMPARs -RRB- by SAP97 anchored protein complexes in classical conditioning .
26149358	0	SAP97	49,54	GluA1	24,29	SAP97	GluA1	1739	2890	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	A Critical Role for the GluA1 Accessory Protein , SAP97 , in Cocaine Seeking .
12050163	0	SAP97	15,20	myosin_VI	57,66	SAP97	myosin VI	25252(Tax:10116)	315840(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of SAP97 with minus-end-directed actin motor myosin_VI .
18665322	0	SAP97	58,63	synapse-associated_protein_97	27,56	SAP97	synapse-associated protein 97	1739	1739	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An association analysis of synapse-associated_protein_97 -LRB- SAP97 -RRB- gene in schizophrenia .
22225629	0	SAP97	92,97	synapse-associated_protein_97	61,90	SAP97	synapse-associated protein 97	1739	1739	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Further evidence for a male-selective genetic association of synapse-associated_protein_97 -LRB- SAP97 -RRB- gene with schizophrenia .
9006895	0	SAPK	153,157	tumor_necrosis_factor-alpha	111,138	SAPK	tumor necrosis factor-alpha	5601	7124	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Actin-binding_protein-280 binds the stress-activated_protein_kinase -LRB- SAPK -RRB- activator SEK-1 and is required for tumor_necrosis_factor-alpha activation of SAPK in melanoma cells .
24645642	0	SAPS_2	26,32	SAPS_3	0,6	SAPS 2	SAPS 3	9701	55291	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	SAPS_3 is not superior to SAPS_2 in cardiac surgery patients .
24645642	0	SAPS_3	0,6	SAPS_2	26,32	SAPS 3	SAPS 2	55291	9701	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|END_ENTITY	SAPS_3 is not superior to SAPS_2 in cardiac surgery patients .
24377927	0	SARA	0,4	EGFR	36,40	SARA	EGFR	9372	1956	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	SARA and RNF11 at the crossroads of EGFR signaling and trafficking .
19620243	0	SARA	8,12	SMAD_anchor_for_receptor_activation	14,49	SARA	SMAD anchor for receptor activation	9372	9372	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of SARA -LRB- SMAD_anchor_for_receptor_activation -RRB- in maintenance of epithelial cell phenotype .
11918675	0	SARA	56,60	Smad_anchor_for_receptor_activation	19,54	SARA	Smad anchor for receptor activation	9372	9372	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The FYVE domain in Smad_anchor_for_receptor_activation -LRB- SARA -RRB- is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling .
22942286	0	SARA	106,110	Smad_anchor_for_receptor_activation	69,104	SARA	Smad anchor for receptor activation	9372	9372	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Phosphatidylinositol_3-kinase and Rab5 GTPase inversely regulate the Smad_anchor_for_receptor_activation -LRB- SARA -RRB- protein independently of transforming_growth_factor-b1 .
25753661	0	SART3	49,54	USIP-1	32,38	SART3	USIP-1	178053(Tax:6239)	179670(Tax:6239)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling .
21232178	0	SATB1	25,30	EZH2	57,61	SATB1	EZH2	6304	2146	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells .
17343824	0	SATB1	0,5	SPARC	16,21	SATB1	SPARC	6304	6678	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron .
20126258	0	SATB1	17,22	beta-catenin	32,44	SATB1	beta-catenin	6304	1499	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Global regulator SATB1 recruits beta-catenin and regulates T -LRB- H -RRB- 2 differentiation in Wnt-dependent manner .
24729451	0	SATB1	59,64	special_AT-rich_binding_protein_1	24,57	SATB1	special AT-rich binding protein 1	20230(Tax:10090)	20230(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Multiple effects of the special_AT-rich_binding_protein_1 -LRB- SATB1 -RRB- in colon_carcinoma .
21677534	0	SATB2	0,5	cytokeratin_20	26,40	SATB2	cytokeratin 20	23314	54474	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	SATB2 in combination with cytokeratin_20 identifies over 95 % of all colorectal_carcinomas .
20980827	0	SATB2	39,44	miR-31	12,18	SATB2	miR-31	23314	407035	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts .
18385318	0	SAX-3	138,143	UNC5	159,163	SAX-3	UNC5	180637(Tax:6239)	177334(Tax:6239)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	RPM-1 , a Caenorhabditis_elegans protein that functions in presynaptic differentiation , negatively regulates axon outgrowth by controlling SAX-3 / robo and UNC-5 / UNC5 activity .
18437680	0	SBDS	53,57	Shwachman-Bodian-Diamond_syndrome	18,51	SBDS	Shwachman-Bodian-Diamond syndrome	51119	51119	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of the Shwachman-Bodian-Diamond_syndrome -LRB- SBDS -RRB- protein in human pancreatic_cancer and chronic_pancreatitis .
18269587	0	SBEM	45,49	small_breast_epithelial_mucin	14,43	SBEM	small breast epithelial mucin	118430	118430	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of small_breast_epithelial_mucin -LRB- SBEM -RRB- protein in tissue microarrays -LRB- TMAs -RRB- of primary invasive breast_cancers .
23749797	0	SBF1	22,26	SET_binding_factor_1	0,20	SBF1	SET binding factor 1	6305	6305	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	SET_binding_factor_1 -LRB- SBF1 -RRB- mutation causes Charcot-Marie-Tooth_disease_type_4B3 .
15304601	0	SBF2	22,26	SET_binding_factor_2	0,20	SBF2	SET binding factor 2	81846	81846	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	SET_binding_factor_2 -LRB- SBF2 -RRB- mutation causes CMT4B with juvenile onset glaucoma .
3747520	0	SBP	63,66	sex_steroid_binding_protein	34,61	SBP	sex steroid binding protein	100009224(Tax:9986)	100009224(Tax:9986)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of the sex_steroid_binding_protein -LRB- SBP -RRB- of plasma .
115376	0	SBP	64,67	steroid-binding_protein	39,62	SBP	steroid-binding protein	8991	8991	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Immunochemical characterization of sex steroid-binding_protein -LRB- SBP -RRB- of human sera .
4041533	0	SBP	87,90	steroid-binding_protein	62,85	SBP	steroid-binding protein	100009224(Tax:9986)	100009224(Tax:9986)	Gene	Gene	studies|appos|START_ENTITY studies|nmod|localization localization|nmod|END_ENTITY	Light and electron microscopic studies on the localization of steroid-binding_protein -LRB- SBP -RRB- in rabbit spermatozoa .
25761752	0	SC-1	97,101	tyrosinase	38,48	SC-1	tyrosinase	6941	7299	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning and identification of a novel tyrosinase and its overexpression in Streptomyces kathirae SC-1 for enhancing melanin production .
19582790	0	SC35	96,100	SRrp37	0,6	SC35	SRrp37	6427	51329	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SRrp37 , a novel splicing regulator located in the nuclear speckles and nucleoli , interacts with SC35 and modulates alternative pre-mRNA splicing in vivo .
19648116	0	SC35	112,116	TBX5	42,46	SC35	TBX5	6427	6910	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram_syndrome via association with SC35 .
15930324	0	SCA-1	8,13	LY6A/E	0,6	SCA-1	LY6A/E	110454(Tax:10090)	110454(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	LY6A/E -LRB- SCA-1 -RRB- expression in the mouse testis .
8615077	0	SCA-1	120,125	spinocerebellar_ataxia_type_1	89,118	SCA-1	spinocerebellar ataxia type 1	6310	6310	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Structural and immunocytochemical features of olivopontocerebellar_atrophy caused by the spinocerebellar_ataxia_type_1 -LRB- SCA-1 -RRB- mutation define a unique phenotype .
17343273	0	SCA-14	16,22	PRKCG	0,5	SCA-14	PRKCG	5582	5582	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	PRKCG mutation -LRB- SCA-14 -RRB- causing a Ramsay Hunt phenotype .
21615679	0	SCA1	107,111	CD31	113,117	SCA1	CD31	20238(Tax:10090)	18613(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|compound|END_ENTITY	In vitro and in vivo proliferation , differentiation and migration of cardiac endothelial progenitor cells -LRB- SCA1 + / CD31 + side-population cells -RRB- .
9097953	0	SCA1	55,59	ataxin-1	74,82	SCA1	ataxin-1	6310	6310	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Identification of a self-association region within the SCA1 gene product , ataxin-1 .
15514462	0	SCA1	55,59	spinocerebellar_ataxia_type-1	24,53	SCA1	spinocerebellar ataxia type-1	25049(Tax:10116)	25049(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prominent expression of spinocerebellar_ataxia_type-1 -LRB- SCA1 -RRB- gene encoding ataxin-1 in LH-producing cells , LbetaT2 .
10335546	0	SCA1	111,115	spinocerebellar_ataxia_type_1	80,109	SCA1	spinocerebellar ataxia type 1	6310	6310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Possible association between schizophrenia and a CAG repeat polymorphism in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene on human chromosome 6p23 .
19597981	0	SCA1	63,67	spinocerebellar_ataxia_type_1	32,61	SCA1	spinocerebellar ataxia type 1	6310	6310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expansion of CAG repeats in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene in idiopathic oligozoospermia patients .
9187671	0	SCA1	85,89	spinocerebellar_ataxia_type_1	54,83	SCA1	spinocerebellar ataxia type 1	6310	6310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of amino-acid and nucleotide variants in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene in schizophrenic patients .
9342197	0	SCA1	77,81	spinocerebellar_ataxia_type_1	46,75	SCA1	spinocerebellar ataxia type 1	6310	6310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparative studies of the CAG repeats in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene .
16211615	0	SCA27	91,96	fibroblast_growth_factor_14	57,84	SCA27	fibroblast growth factor 14	2259	2259	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Spinocerebellar_ataxia associated with a mutation in the fibroblast_growth_factor_14 gene -LRB- SCA27 -RRB- : A new phenotype .
17940722	0	SCA5	25,29	SPTBN2	17,23	SCA5	SPTBN2	6712	6712	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Screening of the SPTBN2 -LRB- SCA5 -RRB- gene in German SCA patients .
10222783	0	SCA6	91,95	spinocerebellar_ataxia_type_6	60,89	SCA6	spinocerebellar ataxia type 6	773	773	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Clinical , neuropathological and genetic characteristics of spinocerebellar_ataxia_type_6 -LRB- SCA6 -RRB- -RSB- .
15612520	0	SCA6	65,69	spinocerebellar_ataxia_type_6	34,63	SCA6	spinocerebellar ataxia type 6	773	773	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Molecular physiopathology of the spinocerebellar_ataxia_type_6 -LRB- SCA6 -RRB- -RSB- .
24990830	0	SCA6	124,128	spinocerebellar_ataxia_type_6	93,122	SCA6	spinocerebellar ataxia type 6	773	773	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Clinical features and MRI findings in spinocerebellar_ataxia_type_31 -LRB- SCA31 -RRB- comparing with spinocerebellar_ataxia_type_6 -LRB- SCA6 -RRB- -RSB- .
12039035	0	SCA7	92,96	spinocerebellar_ataxia_type_7	61,90	SCA7	spinocerebellar ataxia type 7	246103(Tax:10090)	246103(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and expression analysis of the murine homolog of the spinocerebellar_ataxia_type_7 -LRB- SCA7 -RRB- gene .
24374739	0	SCA7	74,78	spinocerebellar_ataxia_type_7	43,72	SCA7	spinocerebellar ataxia type 7	6314	6314	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Founder effect and ancestral origin of the spinocerebellar_ataxia_type_7 -LRB- SCA7 -RRB- mutation in Mexican families .
26054800	0	SCABP8	75,81	AINTEGUMENTA	12,24	SCABP8	AINTEGUMENTA	829437(Tax:3702)	829931(Tax:3702)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Arabidopsis AINTEGUMENTA -LRB- ANT -RRB- mediates salt tolerance by trans-repressing SCABP8 .
12706376	0	SCAD	50,54	short-chain_acyl-CoA_dehydrogenase	14,48	SCAD	short-chain acyl-CoA dehydrogenase	11409(Tax:10090)	11409(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Expression of short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- proteins in the liver of SCAD deficient mice after hydrodynamic gene transfer .
17462936	0	SCAD	54,58	short-chain_acyl-CoA_dehydrogenase	18,52	SCAD	short-chain acyl-CoA dehydrogenase	35	35	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Handling of human short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- variant proteins in transgenic_mice .
9499414	0	SCAD	80,84	short-chain_acyl-CoA_dehydrogenase	44,78	SCAD	short-chain acyl-CoA dehydrogenase	35	35	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of four new mutations in the short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- gene in two patients : one of the variant alleles , 511C -- > T , is present at an unexpectedly high frequency in the general population , as was the case for 625G -- > A , together conferring susceptibility to ethylmalonic_aciduria .
18313299	0	SCALLOPED	0,9	YORKIE	25,31	SCALLOPED	YORKIE	32536(Tax:7227)	37851(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SCALLOPED interacts with YORKIE , the nuclear effector of the hippo tumor-suppressor pathway in Drosophila .
9657850	0	SCAMP1	93,99	secretory_carrier_membrane_protein_1	50,86	SCAMP1	secretory carrier membrane protein 1	9522	9522	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural and functional analysis of the porcine secretory_carrier_membrane_protein_1 gene -LRB- SCAMP1 -RRB- .
16030257	0	SCAMP2	0,6	Arf6	22,26	SCAMP2	Arf6	65168(Tax:10116)	79121(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SCAMP2 interacts with Arf6 and phospholipase_D1 and links their function to exocytotic fusion pore formation in PC12 cells .
16540086	0	SCAND1	111,117	NY-REN-21	52,61	SCAND1	NY-REN-21	51282	7589	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1 .
12036577	0	SCAND2	31,37	SCAN_domain-containing_2	0,24	SCAND2	SCAN domain-containing 2	54581	54581	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	SCAN_domain-containing_2 gene -LRB- SCAND2 -RRB- is a novel nuclear protein derived from the zinc finger family by exon shuffling .
12036577	0	SCAN_domain-containing_2	0,24	SCAND2	31,37	SCAN domain-containing 2	SCAND2	54581	54581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SCAN_domain-containing_2 gene -LRB- SCAND2 -RRB- is a novel nuclear protein derived from the zinc finger family by exon shuffling .
12524230	0	SCAP	59,63	LDL_receptor	32,44	SCAP	LDL receptor	22937	3949	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Synergistic activation of human LDL_receptor expression by SCAP ligand and cytokine oncostatin_M .
16211244	0	SCAP	52,56	LDL_receptor	106,118	SCAP	LDL receptor	22937	3949	Gene	Gene	activation|compound|START_ENTITY activation|nmod|gene gene|compound|END_ENTITY	Blockage of the ERK signaling pathway abrogates the SCAP ligand-induced transcriptional activation of the LDL_receptor gene in HepG2 cells .
10570919	0	SCAP	80,84	SREBP_cleavage-activating_protein	45,78	SCAP	SREBP cleavage-activating protein	22937	22937	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A common Ile796Val polymorphism of the human SREBP_cleavage-activating_protein -LRB- SCAP -RRB- gene .
17963605	0	SCAP	43,47	TNF_alpha	12,21	SCAP	TNF alpha	22937	7124	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of TNF_alpha on the expression of SCAP and triglyceride contents in cultured steatotic hepatocytes -RSB- .
10570913	0	SCAP	134,138	sterol_regulatory_element_binding_protein	55,96	SCAP	sterol regulatory element binding protein	22937	7555	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and chromosomal mapping of the human sterol_regulatory_element_binding_protein -LRB- SREBP -RRB- cleavage-activating protein -LRB- SCAP -RRB- gene .
26919985	0	SCARECROW	25,34	MAX2	14,18	SCARECROW	MAX2	824589(Tax:3702)	818862(Tax:3702)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Expression of MAX2 under SCARECROW promoter enhances the strigolactone/MAX2 dependent response of Arabidopsis roots to low-phosphate conditions .
18160752	0	SCA_2	7,12	MJD	21,24	SCA 2	MJD	6311	4287	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	SCA_1 , SCA_2 _ SCA_3 / MJD mutations in ataxia_syndromes in southern India .
18160752	0	SCA_2	7,12	SCA_3	15,20	SCA 2	SCA 3	6311	4287	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	SCA_1 , SCA_2 _ SCA_3 / MJD mutations in ataxia_syndromes in southern India .
18160752	0	SCA_3	15,20	MJD	21,24	SCA 3	MJD	4287	4287	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	SCA_1 , SCA_2 _ SCA_3 / MJD mutations in ataxia_syndromes in southern India .
18160752	0	SCA_3	15,20	SCA_2	7,12	SCA 3	SCA 2	4287	6311	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	SCA_1 , SCA_2 _ SCA_3 / MJD mutations in ataxia_syndromes in southern India .
9847668	0	SCA_6	66,71	spinocerebellar_ataxia_type_6	35,64	SCA 6	spinocerebellar ataxia type 6	773	773	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Periodic alternating nystagmus in spinocerebellar_ataxia_type_6 -LRB- SCA_6 -RRB- -RSB- .
14639127	0	SCC	39,42	CYP1A1	0,6	SCC	CYP1A1	6317	1543	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	CYP1A1 and XRCC1 gene polymorphisms in SCC of the larynx .
21508366	0	SCC	27,30	EMMPRIN	0,7	SCC	EMMPRIN	6317	682	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	EMMPRIN expression in oral SCC is regulated by FYN kinase .
8188076	0	SCC	76,79	Immunosuppressive_acidic_protein	0,32	SCC	Immunosuppressive acidic protein	6317	3375	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Immunosuppressive_acidic_protein -LRB- IAP -RRB- and squamous_cell_carcinoma antigen -LRB- SCC -RRB- in patients with cervical_cancer .
24273937	0	SCC	81,84	Scc	51,54	SCC	Scc	6317	6317	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of Architect i2000 for determination of Scc with IMX determination of SCC with different methods .
16033098	0	SCC	108,111	proGRP	31,37	SCC	proGRP	6317	2922	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Pro-gastrin-releasing_peptide -LRB- proGRP -RRB- in patients with benign and malignant diseases : comparison with CEA , SCC , CYFRA_21-1_and_NSE in patients with lung_cancer .
16455304	0	SCC-S2	8,14	MMP-1	69,74	SCC-S2	MMP-1	25816	4312	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2 , MMP-1 , and MMP-9 expression .
24560885	0	SCCA1	51,56	p27	29,32	SCCA1	p27	6317	10671	Gene	Gene	generated|nmod|START_ENTITY generated|nsubjpass|END_ENTITY	Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase .
25049903	0	SCD	43,46	Stearoyl-CoA_Desaturase	18,41	SCD	Stearoyl-CoA Desaturase	280924(Tax:9913)	280924(Tax:9913)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Identification of Stearoyl-CoA_Desaturase -LRB- SCD -RRB- Gene Interactions in Korean Native Cattle Based on the Multifactor-dimensionality Reduction Method .
26989730	0	SCD	62,65	Stearoyl-CoA_Desaturase	37,60	SCD	Stearoyl-CoA Desaturase	443185(Tax:9940)	443185(Tax:9940)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	An evolutionary relationship between Stearoyl-CoA_Desaturase -LRB- SCD -RRB- protein sequences involved in fatty_acid metabolism .
20628806	0	SCD	25,28	Stearoyl-CoA_desaturase	0,23	SCD	Stearoyl-CoA desaturase	100860763	100860763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Stearoyl-CoA_desaturase -LRB- SCD -RRB- gene polymorphism in goat breeds .
19577469	0	SCD	70,73	stearoyl-CoA_desaturase	45,68	SCD	stearoyl-CoA desaturase	83792(Tax:10116)	83792(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Potent , orally bioavailable , liver-selective stearoyl-CoA_desaturase -LRB- SCD -RRB- inhibitors .
23124221	0	SCD	58,61	stearoyl-CoA_desaturase	33,56	SCD	stearoyl-CoA desaturase	396670(Tax:9823)	396670(Tax:9823)	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of the gene encoding stearoyl-CoA_desaturase -LRB- SCD -RRB- with fatty_acid composition in an intercross population between Landrace and Korean native pigs .
23139775	0	SCD1	48,52	Stearoyl-CoA_desaturase-1	21,46	SCD1	Stearoyl-CoA desaturase-1	6319	6319	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Heterogeneity of the Stearoyl-CoA_desaturase-1 -LRB- SCD1 -RRB- gene and metabolic risk factors in the EPIC-Potsdam study .
20472560	0	SCD1	53,57	Stomatal_Cytokinesis-Defective_1	19,51	SCD1	Stomatal Cytokinesis-Defective 1	841327(Tax:3702)	841327(Tax:3702)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Novel functions of Stomatal_Cytokinesis-Defective_1 -LRB- SCD1 -RRB- in innate immune responses against bacteria .
18825276	0	SCD1	53,57	stearoyl-CoA_desaturase	28,51	SCD1	stearoyl-CoA desaturase	6319	6319	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Significant associations of stearoyl-CoA_desaturase -LRB- SCD1 -RRB- gene with fat deposition and composition in skeletal muscle .
16741579	0	SCD1	44,48	stearoyl-CoA_desaturase-1	17,42	SCD1	stearoyl-CoA desaturase-1	246074(Tax:10116)	246074(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of stearoyl-CoA_desaturase-1 -LRB- SCD1 -RRB- in the onset of diet-induced hepatic insulin resistance .
24405703	0	SCD1	103,107	stearoyl-CoA_desaturase-1	76,101	SCD1	stearoyl-CoA desaturase-1	246074(Tax:10116)	246074(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	4-Bicyclic_heteroaryl-piperidine derivatives as potent , orally bioavailable stearoyl-CoA_desaturase-1 -LRB- SCD1 -RRB- inhibitors : part 2 .
20723706	0	SCD1	76,80	stearoyl-CoA_desaturase_1	49,74	SCD1	stearoyl-CoA desaturase 1	100860763	100860763	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the polymorphism of the goat stearoyl-CoA_desaturase_1 -LRB- SCD1 -RRB- gene and milk fatty_acid composition in Murciano-Granadina_goats .
22510410	0	SCD5	25,29	EGR2	42,46	SCD5	EGR2	617419(Tax:9913)	100297981	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the bovine SCD5 promoter by EGR2 and SREBP1 .
15274303	0	SCEL	22,26	Sciellin	12,20	SCEL	Sciellin	8796	8796	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of Sciellin -LRB- SCEL -RRB- as a candidate gene in esophageal_squamous_cell_carcinoma .
12002675	0	SCF	30,33	AC133	89,94	SCF	AC133	4254	8842	Gene	Gene	FLT3L|compound|START_ENTITY influence|nsubj|FLT3L influence|nmod|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
23723001	0	SCF	36,39	AMH	29,32	SCF	AMH	4254	268	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of recombinant human AMH on SCF expression in human granulosa cells .
10527462	0	SCF	95,98	CD34	155,159	SCF	CD34	4254	947	Gene	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells reduction|nmod|apoptosis resulted|nsubj|reduction resulted|nmod|proliferation proliferation|compound|END_ENTITY	The reduction of in vitro radiation-induced Fas-related apoptosis in CD34 + progenitor cells by SCF , FLT-3_ligand , TPO , and IL-3 in combination resulted in CD34 + cell proliferation and differentiation .
10527462	0	SCF	95,98	CD34	69,73	SCF	CD34	4254	947	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	The reduction of in vitro radiation-induced Fas-related apoptosis in CD34 + progenitor cells by SCF , FLT-3_ligand , TPO , and IL-3 in combination resulted in CD34 + cell proliferation and differentiation .
11237067	0	SCF	142,145	CD34	23,27	SCF	CD34	4254	947	Gene	Gene	mobilized|nmod|START_ENTITY subsets|dep|mobilized analysis|dep|subsets analysis|nmod|+ +|compound|END_ENTITY	Sequential analysis of CD34 + and CD34 - cell subsets in peripheral blood and leukapheresis products from breast_cancer patients mobilized with SCF plus G-CSF and cyclophosphamide .
12002675	0	SCF	30,33	CD34	96,100	SCF	CD34	4254	947	Gene	Gene	FLT3L|compound|START_ENTITY influence|nsubj|FLT3L influence|nmod|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133 + / CD34 + progenitor cells .
12578718	0	SCF	77,80	CD34	47,51	SCF	CD34	4254	947	Gene	Gene	Stimulated|nmod|START_ENTITY -RSB-|nsubj|Stimulated -RSB-|nmod|Vitro Vitro|nmod|Cells Cells|nmod|END_ENTITY	-LSB- Expension In Vitro of T Cells from Cord Blood CD34 -LRB- + -RRB- Cells Stimulated with SCF and IL-2 -RSB- The generation of large quantities of novel human T cell clones ex vivo would make a wide range of gene-and immuno-therapies for tumor and AIDS possibly .
17971220	0	SCF	83,86	CD34	51,55	SCF	CD34	4254	947	Gene	Gene	combination|nmod|START_ENTITY +|nmod|combination +|nsubj|expansion expansion|nmod|neutrophils neutrophils|nmod|END_ENTITY	Optimal ex vivo expansion of neutrophils from PBSC CD34 + cells by a combination of SCF , Flt3-L and G-CSF and its inhibition by further addition of TPO .
19401563	0	SCF	0,3	COUP-TFII	87,96	SCF	COUP-TFII	4254	7026	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	SCF induces gamma-globin gene expression by regulating downstream transcription factor COUP-TFII .
15014502	0	SCF	15,18	Cdh1	60,64	SCF	Cdh1	4254	999	Gene	Gene	ligase|compound|START_ENTITY ligase|nmod|ubiquitin ubiquitin|appos|END_ENTITY	Control of the SCF -LRB- Skp2-Cks1 -RRB- ubiquitin ligase by the APC/C -LRB- Cdh1 -RRB- ubiquitin ligase .
15093536	0	SCF	74,77	Cdh1	54,58	SCF	Cdh1	4254	999	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Crashing waves of destruction : the cell cycle and APC -LRB- Cdh1 -RRB- regulation of SCF -LRB- Skp2 -RRB- .
11231585	0	SCF	55,58	Cks1	34,38	SCF	Cks1	4254	137529	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The cell-cycle regulatory protein Cks1 is required for SCF -LRB- Skp2 -RRB- - mediated ubiquitinylation of p27 .
18539901	0	SCF	34,37	FIP1L1/PDGFRalpha	0,17	SCF	FIP1L1/PDGFRalpha	17311(Tax:10090)	66899;18595	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	FIP1L1/PDGFRalpha synergizes with SCF to induce systemic_mastocytosis in a murine model of chronic_eosinophilic_leukemia / hypereosinophilic_syndrome .
20543859	0	SCF	49,52	Fbw7	53,57	SCF	Fbw7	4254	55294	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	The ubiquitous nature of cancer : the role of the SCF -LRB- Fbw7 -RRB- complex in development and transformation .
12152985	0	SCF	38,41	G-CSF	86,91	SCF	G-CSF	4254	1440	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	The synergy between stem_cell_factor -LRB- SCF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- : molecular basis and clinical relevance .
12815478	0	SCF	208,211	G-CSF	179,184	SCF	G-CSF	17311(Tax:10090)	100036204(Tax:10090)	Gene	Gene	granulocyte_colony-stimulating_factor|appos|START_ENTITY granulocyte_colony-stimulating_factor|appos|END_ENTITY	Enhanced antileukemic activity of allogeneic peripheral blood progenitor cell transplants following donor treatment with the combination of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and stem_cell_factor -LRB- SCF -RRB- in a murine transplantation model .
10385629	0	SCF	55,58	Hrt1	31,35	SCF	Hrt1	4254	9978	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34 .
15585325	0	SCF	15,18	IL-18	0,5	SCF	IL-18	17311(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IL-18 enhances SCF production of melanoma cells by regulating ROI and p38_MAPK activity .
7507191	0	SCF	16,19	IL-3	34,38	SCF	IL-3	17311(Tax:10090)	16187(Tax:10090)	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|nmod|END_ENTITY	Synergy between SCF or M-CSF with IL-3 or GM-CSF in FDC-P1 cells : a sensitive assay of transforming mutations of c-fms .
18602222	0	SCF	32,35	KIT_ligand	40,50	SCF	KIT ligand	4254	4254	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- , a KIT_ligand , in gastrointestinal_stromal_tumors -LRB- GISTs -RRB- : a potential marker for tumor proliferation .
7540557	0	SCF	41,44	LIF	78,81	SCF	LIF	17311(Tax:10090)	16878(Tax:10090)	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	Hematologic effects of stem_cell_factor -LRB- SCF -RRB- and leukemia_inhibitory_factor -LRB- LIF -RRB- in vivo : LIF-induced thrombocytosis in SCF-primed mice .
18839612	0	SCF	63,66	M-CSF	110,115	SCF	M-CSF	4254	1435	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	-LSB- The plasma levels and diagnostic utility of stem_cell_factor -LRB- SCF -RRB- and macrophage-colony_stimulating_factor -LRB- M-CSF -RRB- in cervical_cancer patients -RSB- .
15531760	0	SCF	36,39	MAFbx	41,46	SCF	MAFbx	4254	114907	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Degradation of MyoD mediated by the SCF -LRB- MAFbx -RRB- ubiquitin ligase .
21368833	0	SCF	0,3	MCL1	52,56	SCF	MCL1	4254	4170	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	SCF -LRB- FBW7 -RRB- regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction .
11953428	0	SCF	35,38	NEDD8	4,9	SCF	NEDD8	4254	4738	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	The NEDD8 pathway is essential for SCF -LRB- beta _ - TrCP -RRB- - mediated ubiquitination and processing of the NF-kappa B precursor p105 .
11250155	0	SCF	114,117	PTEN	0,4	SCF	PTEN	4254	5728	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27 -LRB- KIP1 -RRB- through the ubiquitin E3 ligase SCF -LRB- SKP2 -RRB- .
17438373	0	SCF	14,17	PTEN	86,90	SCF	PTEN	4254	5728	Gene	Gene	ubiquitin|compound|START_ENTITY Regulation|nmod|ubiquitin E3|nsubj|Regulation E3|ccomp|proteolysis proteolysis|nmod|pathway pathway|compound|END_ENTITY	Regulation of SCF -LRB- SKP2 -RRB- ubiquitin E3 ligase assembly and p27 -LRB- KIP1 -RRB- proteolysis by the PTEN pathway and cyclin_D1 .
10579999	0	SCF	20,23	Rbx1	4,8	SCF	Rbx1	4254	9978	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2 .
23263858	0	SCF	30,33	SLF	34,37	SCF	SLF	4254	4254	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Identification of a canonical SCF -LRB- SLF -RRB- complex involved in S-RNase-based self-incompatibility of Pyrus -LRB- Rosaceae -RRB- .
24389104	0	SCF	40,43	Saf1	44,48	SCF	Saf1	4254	4150	Gene	Gene	pathway|compound|START_ENTITY pathway|appos|END_ENTITY	Ubiquitin ligase trapping identifies an SCF -LRB- Saf1 -RRB- pathway targeting unprocessed vacuolar/lysosomal proteins .
10375532	0	SCF	61,64	Skp2	65,69	SCF	Skp2	4254	6502	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
15093536	0	SCF	74,77	Skp2	78,82	SCF	Skp2	4254	6502	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Crashing waves of destruction : the cell cycle and APC -LRB- Cdh1 -RRB- regulation of SCF -LRB- Skp2 -RRB- .
9759910	0	SCF	18,21	Stem_cell_factor	0,16	SCF	Stem cell factor	4254	4254	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Stem_cell_factor -LRB- SCF -RRB- levels in newborns .
21233843	0	SCF	15,18	TAK1	0,4	SCF	TAK1	4254	6885	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TAK1 regulates SCF expression to modulate PKBa activity that protects keratinocytes from ROS-induced apoptosis .
15208392	0	SCF	134,137	TIR1	138,142	SCF	TIR1	4254	825473(Tax:3702)	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Arabidopsis ETA2 , an apparent ortholog of the human cullin-interacting protein CAND1 , is required for auxin responses mediated by the SCF -LRB- TIR1 -RRB- ubiquitin ligase .
20048001	0	SCF	78,81	YAP	56,59	SCF	YAP	4254	10413	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|stability stability|compound|END_ENTITY	A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -LRB- beta-TRCP -RRB- .
22017875	0	SCF	35,38	bTrCP	39,44	SCF	bTrCP	4254	8945	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	mTOR drives its own activation via SCF -LRB- bTrCP -RRB- - dependent degradation of the mTOR inhibitor DEPTOR .
26217795	0	SCF	69,72	bTrCP	73,78	SCF	bTrCP	4254	8945	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Datasets from an interaction proteomics screen for substrates of the SCF -LRB- bTrCP -RRB- ubiquitin ligase .
20708156	0	SCF	89,92	beta-TRCP	93,102	SCF	beta-TRCP	4254	8945	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Phosphorylation by casein_kinase_I promotes the turnover of the Mdm2 oncoprotein via the SCF -LRB- beta-TRCP -RRB- ubiquitin ligase .
11238952	0	SCF	76,79	betaTrCP	80,88	SCF	betaTrCP	4254	8945	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF -LRB- betaTrCP -RRB- ubiquitin ligase .
26592659	0	SCF	46,49	c-KIT	51,56	SCF	c-KIT	4254	3815	Gene	Gene	stem_cell_factor|appos|START_ENTITY down-regulate|dep|stem_cell_factor down-regulate|dep|system system|amod|END_ENTITY	Estrogens down-regulate the stem_cell_factor -LRB- SCF -RRB- / c-KIT system in prostate cells : Evidence of antiproliferative and proapoptotic effects .
17493588	0	SCF	36,39	c-Kit	41,46	SCF	c-Kit	4254	3815	Gene	Gene	stem_cell_factor|appos|START_ENTITY inhibited|dep|stem_cell_factor inhibited|dep|proliferation proliferation|amod|END_ENTITY	Chrysin inhibited stem_cell_factor -LRB- SCF -RRB- / c-Kit complex-induced cell proliferation in human myeloid_leukemia cells .
21279973	0	SCF	35,38	c-Kit	14,19	SCF	c-Kit	4254	3815	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of c-Kit and its ligand SCF in primary uveal_melanoma .
7577648	0	SCF	43,46	c-Kit	11,16	SCF	c-Kit	4254	3815	Gene	Gene	Changes|nmod|START_ENTITY Changes|nmod|expression expression|amod|END_ENTITY	Changes in c-Kit expression and effects of SCF during differentiation of human erythroid progenitor cells .
9462703	0	SCF	48,51	c-Kit	18,23	SCF	c-Kit	4254	3815	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|receptor receptor|amod|END_ENTITY	Expression of the c-Kit receptor and its ligand SCF in non-small-cell_lung_carcinomas .
11222388	0	SCF	75,78	c-kit	89,94	SCF	c-kit	4254	3815	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor -LRB- c-kit -RRB- in a human myeloid_leukemia cell line and in acute myeloid_leukemia blasts .
17214848	0	SCF	55,58	c-kit	89,94	SCF	c-kit	4254	3815	Gene	Gene	bFGF|dep|START_ENTITY factors|appos|bFGF factors|appos|FGFR-1 FGFR-1|dep|END_ENTITY	Protein expression of melanocyte growth factors -LRB- bFGF , SCF -RRB- and their receptors -LRB- FGFR-1 , c-kit -RRB- in nevi and melanoma .
18006465	0	SCF	37,40	c-kit	95,100	SCF	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	injection|appos|START_ENTITY improves|nsubj|injection improves|ccomp|delivered delivered|iobj|bone bone|amod|END_ENTITY	Local injection of stem_cell_factor -LRB- SCF -RRB- improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells .
20850173	0	SCF	44,47	c-kit	16,21	SCF	c-kit	4254	3815	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of c-kit and stem_cell_factor -LRB- SCF -RRB- in ovarian follicular epithelium of a lizard , Podarcis s. sicula .
26428235	0	SCF	90,93	c-kit	10,15	SCF	c-kit	4254	3815	Gene	Gene	stem_cell_factor|appos|START_ENTITY using|dobj|stem_cell_factor neuroblastomas|acl|using Targeting|nmod|neuroblastomas Targeting|dobj|receptor receptor|amod|END_ENTITY	Targeting c-kit receptor in neuroblastomas and colorectal_cancers using stem_cell_factor -LRB- SCF -RRB- - based recombinant bacterial toxins .
7529338	0	SCF	72,75	c-kit	18,23	SCF	c-kit	4254	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|proto-oncogene proto-oncogene|amod|END_ENTITY	Expression of the c-kit proto-oncogene and its ligand stem_cell_factor -LRB- SCF -RRB- in normal and malignant human testicular tissue .
8691142	0	SCF	29,32	c-kit	35,40	SCF	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	stem_cell_factor|appos|START_ENTITY role|nmod|stem_cell_factor role|dep|interaction interaction|amod|END_ENTITY	A role for stem_cell_factor -LRB- SCF -RRB- : c-kit interaction -LRB- s -RRB- in the intestinal tract response to Salmonella_typhimurium infection .
8698135	0	SCF	23,26	c-kit	62,67	SCF	c-kit	4254	3815	Gene	Gene	protein|compound|START_ENTITY use|nmod|protein use|nmod|expression expression|amod|END_ENTITY	The use of recombinant SCF protein for rapid determination of c-kit expression in normal and abnormal erythropoiesis .
9508539	0	SCF	67,70	c-kit	28,33	SCF	c-kit	4254	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of protooncogene c-kit and its ligand stem_cell_factor -LRB- SCF -RRB- in gastric_carcinoma cell lines .
9858422	0	SCF	32,35	c-kit	55,60	SCF	c-kit	4254	3815	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- and SCF receptor -LRB- c-kit -RRB- in synovial membrane in arthritis : correlation with synovial mast_cell_hyperplasia and inflammation .
7529540	0	SCF	48,51	c-kit_ligand	34,46	SCF	c-kit ligand	4254	4254	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Expression and functional role of c-kit_ligand -LRB- SCF -RRB- in human multiple_myeloma cells .
19084516	0	SCF	0,3	cyclin_E2	25,34	SCF	cyclin E2	4254	9134	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	SCF -LRB- Fbxw7/hCdc4 -RRB- targets cyclin_E2 for ubiquitin-dependent proteolysis .
23926677	0	SCF	54,57	glial_cell-derived_neurotrophic_factor	12,50	SCF	glial cell-derived neurotrophic factor	60427(Tax:10116)	25453(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	-LSB- Effects of glial_cell-derived_neurotrophic_factor on SCF protein and antioxidant enzyme activity in the testis of unilateral_cryptorchidism rats -RSB- .
24667174	0	SCF	62,65	hFBH1	66,71	SCF	hFBH1	4254	84893	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Synergistic effect of two E2 ubiquitin conjugating enzymes in SCF -LRB- hFBH1 -RRB- catalyzed polyubiquitination .
1375477	0	SCF	44,47	stem_cell_factor	26,42	SCF	stem cell factor	4254	4254	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant stem_cell_factor -LRB- SCF -RRB- on purified CD34-positive human umbilical cord blood progenitor cells .
14563684	0	SCF	35,38	stem_cell_factor	17,33	SCF	stem cell factor	4254	4254	Gene	Gene	Transcription|appos|START_ENTITY Transcription|nmod|END_ENTITY	Transcription of stem_cell_factor -LRB- SCF -RRB- is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element .
14662725	0	SCF	64,67	stem_cell_factor	46,62	SCF	stem cell factor	4254	4254	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Paradoxical early glucocorticoid induction of stem_cell_factor -LRB- SCF -RRB- expression in inflammatory conditions .
1717499	0	SCF	47,50	stem_cell_factor	29,45	SCF	stem cell factor	4254	4254	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human stem_cell_factor -LRB- SCF -RRB- on the growth of human progenitor cells in vitro .
18602222	0	SCF	32,35	stem_cell_factor	14,30	SCF	stem cell factor	4254	4254	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- , a KIT_ligand , in gastrointestinal_stromal_tumors -LRB- GISTs -RRB- : a potential marker for tumor proliferation .
7517201	0	SCF	29,32	stem_cell_factor	11,27	SCF	stem cell factor	4254	4254	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of stem_cell_factor -LRB- SCF -RRB- on human marrow neutrophil , neutrophil/macrophage mixed , macrophage and eosinophil progenitor cell growth .
7693028	0	SCF	29,32	stem_cell_factor	11,27	SCF	stem cell factor	4254	4254	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of stem_cell_factor -LRB- SCF -RRB- on the in vitro growth of leukemic blast progenitors in acute_non-lymphocytic_leukemia .
9209436	0	SCF	30,33	stem_cell_factor	12,28	SCF	stem cell factor	4254	4254	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Role of the stem_cell_factor -LRB- SCF -RRB- receptor and the alternative forms of its ligand -LRB- SCF -RRB- in the induction of long-term growth by stroma cells .
9209436	0	SCF	85,88	stem_cell_factor	12,28	SCF	stem cell factor	4254	4254	Gene	Gene	Role|appos|START_ENTITY Role|nmod|receptor receptor|compound|END_ENTITY	Role of the stem_cell_factor -LRB- SCF -RRB- receptor and the alternative forms of its ligand -LRB- SCF -RRB- in the induction of long-term growth by stroma cells .
11959419	0	SCG-10	42,48	super_cervical_ganglion-10	14,40	SCG-10	super cervical ganglion-10	11075	11075	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of super_cervical_ganglion-10 -LRB- SCG-10 -RRB- mRNA in the monkey cerebral cortex during postnatal development .
18452648	0	SCG10	21,26	BRI3	0,4	SCG10	BRI3	84510(Tax:10116)	304284(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells .
16618812	0	SCG10	24,29	JNK1	0,4	SCG10	JNK1	11075	5599	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic_length .
20621975	0	SCG10	19,24	KBP	0,3	SCG10	KBP	84510(Tax:10116)	606294(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	KBP interacts with SCG10 , linking Goldberg-Shprintzen_syndrome to microtubule dynamics and neuronal differentiation .
12140291	0	SCG10	20,25	RGS6	0,4	SCG10	RGS6	84510(Tax:10116)	54295(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RGS6 interacts with SCG10 and promotes neuronal differentiation .
17145186	0	SCG10	103,108	SCLIP	25,30	SCG10	SCLIP	11075	50861	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The `` SCG10-LIke_Protein '' SCLIP is a novel regulator of axonal branching in hippocampal neurons , unlike SCG10 .
25869138	0	SCG10	49,54	Spy1	0,4	SCG10	Spy1	11075	245711	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Spy1 mediates phosphorylation and degradation of SCG10 in axonal_degeneration .
2837417	0	SCG10	41,46	nerve_growth_factor	51,70	SCG10	nerve growth factor	84510(Tax:10116)	310738(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The induction of a neural-specific gene , SCG10 , by nerve_growth_factor in PC12 cells is transcriptional , protein synthesis dependent , and glucocorticoid inhibitable .
11718727	0	SCG10	141,146	stress-activated_protein_kinase-beta	33,69	SCG10	stress-activated protein kinase-beta	11075	5602	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	c-Jun_N-terminal_kinase-3 -LRB- JNK3 -RRB- / stress-activated_protein_kinase-beta -LRB- SAPKbeta -RRB- binds and phosphorylates the neuronal microtubule regulator SCG10 .
17200173	0	SCG3	69,73	secretogranin_III	50,67	SCG3	secretogranin III	29106	29106	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional single-nucleotide polymorphisms in the secretogranin_III -LRB- SCG3 -RRB- gene that form secretory granules with appetite-related neuropeptides are associated with obesity .
23820082	0	SCGB1A1	27,34	Secretoglobin_1A_member_1	0,25	SCGB1A1	Secretoglobin 1A member 1	7356	7356	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Secretoglobin_1A_member_1 -LRB- SCGB1A1 -RRB- +38 A/G polymorphism is associated with asthma risk : a meta-analysis .
24710847	0	SCGB3A1	17,24	UGRP2	26,31	SCGB3A1	UGRP2	92304	92304	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Investigation of SCGB3A1 -LRB- UGRP2 -RRB- gene arrays in patients with nasal_polyposis .
21170691	0	SCGB3A2	51,58	secretoglobin_3A2	32,49	SCGB3A2	secretoglobin 3A2	117156	117156	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The -112 G > A polymorphism of the secretoglobin_3A2 -LRB- SCGB3A2 -RRB- gene encoding uteroglobin-related_protein_1 -LRB- UGRP1 -RRB- increases risk for the development of Graves ' _ disease in subsets of patients with elevated levels of immunoglobulin_E .
17055402	0	SCHAD	67,72	short-chain_3-hydroxyacyl-CoA_dehydrogenase	74,117	SCHAD	short-chain 3-hydroxyacyl-CoA dehydrogenase	3033	3033	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Homicide followed by freezing and burning : usefulness of measuring SCHAD -LRB- short-chain_3-hydroxyacyl-CoA_dehydrogenase -RRB- activity .
26851521	0	SCID	56,60	Prkdc	50,55	SCID	Prkdc	19090(Tax:10090)	19090(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Simple and reliable genotyping protocol for mouse Prkdc -LRB- SCID -RRB- mutation .
10068633	0	SCIP	17,21	Krox-20	0,7	SCIP	Krox-20	18991(Tax:10090)	13654(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|controls controls|amod|END_ENTITY	Krox-20 controls SCIP expression , cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells .
16483709	0	SCL	24,27	sarcolectin	11,22	SCL	sarcolectin	3855	3855	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of sarcolectin -LRB- SCL -RRB- on human peripheral blood mononuclear cells .
16038898	0	SCLIP	25,30	Clusterin	0,9	SCLIP	Clusterin	29246(Tax:10116)	24854(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Clusterin interacts with SCLIP -LRB- SCG10-like_protein -RRB- and promotes neurite outgrowth of PC12 cells .
17135267	0	SCLIP	0,5	RasGRF1	58,65	SCLIP	RasGRF1	29246(Tax:10116)	192213(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SCLIP , a microtubule-destabilizing factor , interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth .
17145186	0	SCLIP	25,30	SCG10	103,108	SCLIP	SCG10	50861	11075	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The `` SCG10-LIke_Protein '' SCLIP is a novel regulator of axonal branching in hippocampal neurons , unlike SCG10 .
25605328	0	SCML2	21,26	USP7	0,4	SCML2	USP7	10389	7874	Gene	Gene	COOPERATES|nmod|START_ENTITY COOPERATES|nsubj|END_ENTITY	USP7 COOPERATES WITH SCML2 TO REGULATE THE ACTIVITY OF PRC1 .
25634095	0	SCML2	17,22	USP7	39,43	SCML2	USP7	107815(Tax:10090)	252870(Tax:10090)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis .
18400210	0	SCN	79,82	Per1	47,51	SCN	Per1	24766(Tax:10116)	287422(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of 5-HT2C receptors acutely induces Per1 gene expression in the rat SCN in vitro .
27037800	0	SCN1	68,72	PLURIPETALA	0,11	SCN1	PLURIPETALA	819979(Tax:3702)	825107(Tax:3702)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	PLURIPETALA mediates ROP2 localization and stability in parallel to SCN1 but synergistically with TIP1 in root hairs .
26189305	0	SCN1A	14,19	ABCC2	7,12	SCN1A	ABCC2	6323	1244	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
26189305	0	SCN1A	14,19	GABRA1	28,34	SCN1A	GABRA1	6323	2554	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
24337656	0	SCN1A	90,95	SCN1B	111,116	SCN1A	SCN1B	6323	6324	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN1A	90,95	SCN2A	97,102	SCN1A	SCN2A	6323	6326	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
26189305	0	SCN1A	14,19	SCN2A	21,26	SCN1A	SCN2A	6323	6326	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
24337656	0	SCN1A	90,95	SCN3A	104,109	SCN1A	SCN3A	6323	6328	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN1B	111,116	SCN1A	90,95	SCN1B	SCN1A	6324	6323	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN1B	111,116	SCN2A	97,102	SCN1B	SCN2A	6324	6326	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN1B	111,116	SCN3A	104,109	SCN1B	SCN3A	6324	6328	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
26189305	0	SCN2A	21,26	ABCC2	7,12	SCN2A	ABCC2	6326	1244	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
26189305	0	SCN2A	21,26	GABRA1	28,34	SCN2A	GABRA1	6326	2554	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
24337656	0	SCN2A	97,102	SCN1A	90,95	SCN2A	SCN1A	6326	6323	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
26189305	0	SCN2A	21,26	SCN1A	14,19	SCN2A	SCN1A	6326	6323	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	ABCB1 , ABCC2 , SCN1A , SCN2A , GABRA1 gene polymorphisms and drug resistant epilepsy in the Chinese Han population .
24337656	0	SCN2A	97,102	SCN1B	111,116	SCN2A	SCN1B	6326	6324	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN2A	97,102	SCN3A	104,109	SCN2A	SCN3A	6326	6328	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN3A	104,109	SCN1A	90,95	SCN3A	SCN1A	6328	6323	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN3A	104,109	SCN1B	111,116	SCN3A	SCN1B	6328	6324	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24337656	0	SCN3A	104,109	SCN2A	97,102	SCN3A	SCN2A	6328	6326	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A , SCN2A , SCN3A , SCN1B , and SCN2B and epilepsy .
24403053	0	SCO1	28,32	COX20	6,11	SCO1	COX20	6341	116228	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase .
19336478	0	SCO2	6,10	CO_II	44,49	SCO2	CO II	9997	4513	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|synthesis synthesis|nmod|END_ENTITY	Human SCO2 is required for the synthesis of CO_II and as a thiol-disulphide oxidoreductase for SCO1 .
12534938	0	SCOT	53,57	succinyl_CoA_transferase	27,51	SCOT	succinyl CoA transferase	64059(Tax:10090)	64059(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Differential expression of succinyl_CoA_transferase -LRB- SCOT -RRB- genes in somatic and germline cells of the mouse testis .
26144236	0	SCP-2	102,107	sterol_carrier_protein_type_2	71,100	SCP-2	sterol carrier protein type 2	6342	6342	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Synthesis , purification and crystallographic studies of the C-terminal sterol_carrier_protein_type_2 -LRB- SCP-2 -RRB- domain of human hydroxysteroid_dehydrogenase-like_protein_2 .
25893300	0	SCP1	0,4	c-Myc	15,20	SCP1	c-Myc	58190	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62 .
24226717	0	SCP2	32,36	HMGCR	41,46	SCP2	HMGCR	6342	3156	Gene	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	Increased bile lithogenicity by SCP2 via HMGCR and CYP7A1 regulation in human hepatocytes .
3371541	0	SCP2	39,43	sterol_carrier_protein2	14,37	SCP2	sterol carrier protein2	25541(Tax:10116)	25541(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Regulation of sterol_carrier_protein2 -LRB- SCP2 -RRB- levels in the soluble fraction of rat Leydig cells .
8640304	0	SCP2	40,44	sterol_carrier_protein_2	14,38	SCP2	sterol carrier protein 2	6342	6342	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of sterol_carrier_protein_2 -LRB- SCP2 -RRB- in human adrenocortical tissue .
3958137	0	SCPN	49,53	serum_carboxypeptidase_N	23,47	SCPN	serum carboxypeptidase N	1369	1369	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Decreased synthesis of serum_carboxypeptidase_N -LRB- SCPN -RRB- in familial SCPN_deficiency .
9245689	0	SCPx	154,158	beta-ketothiolase	64,81	SCPx	beta-ketothiolase	6342	30	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Sterol_carrier_protein_X -LRB- SCPx -RRB- is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA : a new , unique role for SCPx in branched-chain fatty_acid metabolism in peroxisomes .
9245689	0	SCPx	26,30	beta-ketothiolase	64,81	SCPx	beta-ketothiolase	6342	30	Gene	Gene	Sterol_carrier_protein_X|appos|START_ENTITY END_ENTITY|nsubj|Sterol_carrier_protein_X	Sterol_carrier_protein_X -LRB- SCPx -RRB- is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA : a new , unique role for SCPx in branched-chain fatty_acid metabolism in peroxisomes .
17401362	0	SCRM-1	133,139	WAH-1	32,37	SCRM-1	WAH-1	173053(Tax:6239)	176635(Tax:6239)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	C. _ elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1 .
25399950	0	SCRN1	50,55	miR-148a	21,29	SCRN1	miR-148a	9805	406940	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	A genetic variant of miR-148a binding site in the SCRN1 3 ' - UTR is associated with susceptibility and prognosis of gastric_cancer .
25541225	0	SCUBE-1	79,86	signal_peptide-Cub-Egf_domain-containing_protein-1	27,77	SCUBE-1	signal peptide-Cub-Egf domain-containing protein-1	80274	80274	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Diagnostic value of plasma signal_peptide-Cub-Egf_domain-containing_protein-1 -LRB- SCUBE-1 -RRB- in an experimental model of acute ischemic_stroke .
20059955	0	SCX	74,77	Bmp4	92,96	SCX	Bmp4	642658	652	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton_junction .
10049733	0	SCYA13	106,112	MCP-4	84,89	SCYA13	MCP-4	6357	6357	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization , sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene -LRB- SCYA13 -RRB- in dermal fibroblasts : a comparison to other eosinophilic beta-chemokines .
10049593	0	SCYA18	21,27	PARC	10,14	SCYA18	PARC	6362	6362	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chemokine PARC gene -LRB- SCYA18 -RRB- generated by fusion of two MIP-1alpha / LD78alpha-like genes .
15389752	0	SCYA2	12,17	MCP-1	0,5	SCYA2	MCP-1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	MCP-1 gene -LRB- SCYA2 -RRB- and schizophrenia : a case-control association study .
19923858	0	SCYA2	16,21	MCP-1	4,9	SCYA2	MCP-1	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The MCP-1 gene -LRB- SCYA2 -RRB- and mood_disorders : preliminary results of a case-control association study .
2071154	0	SCYA2	58,63	small_inducible_cytokine_A2	24,51	SCYA2	small inducible cytokine A2	6347	6347	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human small_inducible_cytokine_A2 gene , SCYA2 -LRB- encoding JE or MCP-1 -RRB- , to 17q11.2-12 : evolutionary relatedness of cytokines clustered at the same locus .
11749970	0	SCYA20	63,69	tumor_necrosis_factor-alpha	106,133	SCYA20	tumor necrosis factor-alpha	6364	7124	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Human macrophage_inflammatory_protein-3alpha / CCL20/LARC/Exodus / SCYA20 is transcriptionally upregulated by tumor_necrosis_factor-alpha via a non-standard NF-kappaB site .
7916328	0	SCYA7	22,27	MCP-3	10,15	SCYA7	MCP-3	6354	6354	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human MCP-3 gene -LRB- SCYA7 -RRB- : cloning , sequence analysis , and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12 .
9119400	0	SCYA8	22,27	MCP-2	10,15	SCYA8	MCP-2	6355	6355	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human MCP-2 gene -LRB- SCYA8 -RRB- : cloning , sequence analysis , tissue expression , and assignment to the CC chemokine gene contig on chromosome 17q11 .2 .
12169689	0	SCYB11	104,110	beta-R1	95,102	SCYB11	beta-R1	6373	6373	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Requirement of phosphoinositide_3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 -LRB- SCYB11 -RRB- gene .
22570270	0	SCYL1_binding_protein_1	0,23	Pirh2	72,77	SCYL1 binding protein 1	Pirh2	98376(Tax:10090)	68098(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	SCYL1_binding_protein_1 promotes the ubiquitin-dependent degradation of Pirh2 and has tumor-suppressive function in the development of hepatocellular_carcinoma .
24190321	0	SD	27,29	Segregation_Distorter	4,25	SD	Segregation Distorter	35223(Tax:7227)	35223(Tax:7227)	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	The Segregation_Distorter -LRB- SD -RRB- complex and the accumulation of deleterious genes in laboratory strains of Drosophila_melanogaster .
12511407	0	SDF-1	153,158	C3a	106,109	SDF-1	C3a	6387	718	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells , and C3a enhances their homing-related responses to SDF-1 .
16148115	0	SDF-1	32,37	C3a	11,14	SDF-1	C3a	6387	718	Gene	Gene	CXCL12|appos|START_ENTITY CXCL12|compound|END_ENTITY	Complement C3a enhances CXCL12 -LRB- SDF-1 -RRB- - mediated chemotaxis of bone marrow hematopoietic cells independently of C3a_receptor .
12004084	0	SDF-1	136,141	CD34	18,22	SDF-1	CD34	6387	947	Gene	Gene	response|nmod|START_ENTITY have|nmod|response have|nsubj|cells cells|compound|END_ENTITY	Immature leukemic CD34 + CXCR4 + cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1 .
11544290	0	SDF-1	134,139	CD4	143,146	SDF-1	CD4	6387	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Diverse transcriptional response of CD4 + T cells to stromal cell-derived factor SDF-1 : cell survival promotion and priming effects of SDF-1 on CD4 + T cells .
11544290	0	SDF-1	80,85	CD4	36,39	SDF-1	CD4	6387	920	Gene	Gene	stromal|dobj|START_ENTITY cells|acl|stromal cells|compound|END_ENTITY	Diverse transcriptional response of CD4 + T cells to stromal cell-derived factor SDF-1 : cell survival promotion and priming effects of SDF-1 on CD4 + T cells .
15070674	0	SDF-1	40,45	CD44	0,4	SDF-1	CD44	6387	960	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34 + stem/progenitor cells to bone marrow .
11870628	0	SDF-1	48,53	CXCL12	40,46	SDF-1	CXCL12	6387	6387	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Activation of pertussis toxin-sensitive CXCL12 -LRB- SDF-1 -RRB- receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells .
14684377	0	SDF-1	0,5	CXCL12	6,12	SDF-1	CXCL12	6387	6387	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	SDF-1 / CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 .
15882617	0	SDF-1	119,124	CXCL12	125,131	SDF-1	CXCL12	6387	6387	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Stromal fibroblasts present in invasive human breast_carcinomas promote tumor growth and angiogenesis through elevated SDF-1 / CXCL12 secretion .
16212649	0	SDF-1	14,19	CXCL12	20,26	SDF-1	CXCL12	6387	6387	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|END_ENTITY	The chemokine SDF-1 / CXCL12 contributes to T lymphocyte recruitment in human pre-ovulatory follicles and coordinates with lymphocytes to increase granulosa cell survival and embryo quality .
16259636	0	SDF-1	48,53	CXCL12	55,61	SDF-1	CXCL12	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The neuroblast and angioblast chemotaxic factor SDF-1 -LRB- CXCL12 -RRB- expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic_injury .
16702540	0	SDF-1	14,19	CXCL12	20,26	SDF-1	CXCL12	6387	6387	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|END_ENTITY	The chemokine SDF-1 / CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4 .
19281787	0	SDF-1	14,19	CXCL12	20,26	SDF-1	CXCL12	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	The chemokine SDF-1 / CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles .
19937807	0	SDF-1	14,19	CXCL12	20,26	SDF-1	CXCL12	24772(Tax:10116)	24772(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|END_ENTITY	The chemokine SDF-1 / CXCL12 contributes to the ` homing ' of umbilical cord blood cells to a hypoxic-ischemic_lesion in the rat brain .
20459090	0	SDF-1	10,15	CXCL12	16,22	SDF-1	CXCL12	6387	6387	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting SDF-1 / CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design .
20869048	0	SDF-1	48,53	CXCL12	54,60	SDF-1	CXCL12	6387	6387	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Estrogen induces stromal cell-derived factor 1 -LRB- SDF-1 / CXCL12 -RRB- production in human endometrial stromal cells : a possible role of endometrial epithelial cell growth .
22951280	0	SDF-1	24,29	CXCL12	30,36	SDF-1	CXCL12	6387	6387	Gene	Gene	involvement|nmod|START_ENTITY involvement|dep|END_ENTITY	Possible involvement of SDF-1 / CXCL12 in the pathogenesis of Degos_disease .
24292718	0	SDF-1	25,30	CXCL12	31,37	SDF-1	CXCL12	6387	6387	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	The peculiarities of the SDF-1 / CXCL12 system : in some cells , CXCR4 and CXCR7 sing solos , in others , they sing duets .
25466898	0	SDF-1	0,5	CXCL12	6,12	SDF-1	CXCL12	6387	6387	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|END_ENTITY	SDF-1 / CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gai/mTORC1 axis .
26093947	0	SDF-1	8,13	CXCL12	15,21	SDF-1	CXCL12	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of SDF-1 -LRB- CXCL12 -RRB- in regulating hematopoietic stem and progenitor cells traffic into the liver during extramedullary hematopoiesis induced by G-CSF , AMD3100 and PHZ .
18827024	0	SDF-1	188,193	CXCR-4	181,187	SDF-1	CXCR-4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	axis|nsubj|START_ENTITY administration|parataxis|axis administration|acl|associated associated|nmod|homing homing|nmod|END_ENTITY	Erythropoietin administration after myocardial_infarction in mice attenuates ischemic_cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4 / SDF-1 axis .
25338599	0	SDF-1	76,81	CXCR-4	82,88	HMGB1	CXCR-4	3146	7852	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Extracellular HMGB1 Promotes the Migration of Cord Blood CD34 -LRB- + -RRB- Cells via SDF-1 / CXCR-4 Axis -RSB- .
10556181	0	SDF-1	0,5	CXCR4	45,50	SDF-1	CXCR4	6387	7852	Gene	Gene	responsiveness|compound|START_ENTITY correlate|nsubj|responsiveness correlate|nmod|levels levels|nummod|END_ENTITY	SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells .
10602415	0	SDF-1	169,174	CXCR4	41,46	SDF-1	CXCR4	6387	7852	Gene	Gene	stromal_cell-derived_factor-1|appos|START_ENTITY response|nmod|stromal_cell-derived_factor-1 associated|nmod|response associated|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of the chemokine receptor CXCR4 in B_cell_chronic_lymphocytic_leukemia is associated with increased functional response to stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
11458529	1	SDF-1	107,112	CXCR4	113,118	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY /|nsubj|role /|dobj|interactions interactions|nummod|END_ENTITY	The role of SDF-1 / CXCR4 interactions .
11867624	0	SDF-1	138,143	CXCR4	78,83	SDF-1	CXCR4	6387	7852	Gene	Gene	processing|nmod|START_ENTITY regulates|nmod|processing regulates|dobj|factor-1 factor-1|dep|binding binding|compound|END_ENTITY	Leukocyte_elastase negatively regulates Stromal cell-derived factor-1 -LRB- SDF-1 -RRB- / CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4 .
11867624	0	SDF-1	71,76	CXCR4	78,83	SDF-1	CXCR4	6387	7852	Gene	Gene	factor-1|appos|START_ENTITY factor-1|dep|binding binding|compound|END_ENTITY	Leukocyte_elastase negatively regulates Stromal cell-derived factor-1 -LRB- SDF-1 -RRB- / CXCR4 binding and functions by amino-terminal processing of SDF-1 and CXCR4 .
11985470	0	SDF-1	29,34	CXCR4	121,126	SDF-1	CXCR4	6387	7852	Gene	Gene	analogue|compound|START_ENTITY cyclization|nmod|analogue increases|nsubj|cyclization increases|dobj|affinity affinity|nmod|receptor receptor|compound|END_ENTITY	C-terminal cyclization of an SDF-1 small peptide analogue dramatically increases receptor affinity and activation of the CXCR4 receptor .
12004084	0	SDF-1	136,141	CXCR4	23,28	SDF-1	CXCR4	6387	7852	Gene	Gene	response|nmod|START_ENTITY have|nmod|response have|nsubj|cells cells|compound|END_ENTITY	Immature leukemic CD34 + CXCR4 + cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1 .
12122049	0	SDF-1	106,111	CXCR4	26,31	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	plasticity|compound|START_ENTITY regulation|nmod|plasticity system|dep|regulation system|nummod|END_ENTITY	A dual role for the SDF-1 / CXCR4 chemokine receptor system in adult brain : isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia .
12122049	0	SDF-1	20,25	CXCR4	26,31	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|system system|nummod|END_ENTITY	A dual role for the SDF-1 / CXCR4 chemokine receptor system in adult brain : isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia .
12239139	0	SDF-1	41,46	CXCR4	153,158	SDF-1	CXCR4	6387	7852	Gene	Gene	CXCL12|appos|START_ENTITY CXCL12|nmod|receptor receptor|compound|END_ENTITY	CCR5-binding chemokines modulate CXCL12 -LRB- SDF-1 -RRB- - induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor .
12761880	0	SDF-1	32,37	CXCR4	14,19	SDF-1	CXCR4	6387	7852	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CXCR4 and CXCL12 -LRB- SDF-1 -RRB- in human prostate_cancers -LRB- PCa -RRB- in vivo .
14555820	0	SDF-1	45,50	CXCR4	69,74	SDF-1	CXCR4	6387	7852	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- and expression of CXCR4 in human bone marrow endothelial cells .
14684377	0	SDF-1	0,5	CXCR4	92,97	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|regulates regulates|dobj|production production|nmod|cells cells|nmod|END_ENTITY	SDF-1 / CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4 .
14688392	0	SDF-1	39,44	CXCR4	45,50	SDF-1	CXCR4	6387	7852	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Mobilization of myeloma cells involves SDF-1 / CXCR4 signaling and downregulation of VLA-4 .
15033938	0	SDF-1	156,161	CXCR4	13,18	SDF-1	CXCR4	6387	7852	Gene	Gene	CXC|appos|START_ENTITY binds|dobj|CXC binds|nsubj|complex complex|compound|END_ENTITY	A syndecan-4 / CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC chemokine stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
15078139	0	SDF-1	71,76	CXCR4	77,82	SDF-1	CXCR4	6387	7852	Gene	Gene	role|nmod|START_ENTITY Chemokines|dep|role Chemokines|parataxis|axis axis|nsubj|END_ENTITY	Chemokines and their receptors as therapeutic targets : the role of the SDF-1 / CXCR4 axis .
15328152	0	SDF-1	126,131	CXCR4	17,22	SDF-1	CXCR4	6387	7852	Gene	Gene	gradient|compound|START_ENTITY primes|nmod|gradient primes|nsubj|Incorporation Incorporation|nmod|END_ENTITY	Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic stem/progenitor cells to an SDF-1 gradient .
15542441	0	SDF-1	31,36	CXCR4	38,43	SDF-1	CXCR4	6387	7852	Gene	Gene	Stromal_cell-derived_factor-1|appos|START_ENTITY \|nsubj|Stromal_cell-derived_factor-1 \|ccomp|plays plays|nsubj|couple couple|compound|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- \ CXCR4 couple plays multiple roles on haematopoietic progenitors at the border between the old cytokine and new chemokine worlds : survival , cell cycling and trafficking .
15647826	0	SDF-1	48,53	CXCR4	62,67	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|parataxis|blocks blocks|nsubj|axis axis|compound|END_ENTITY	Skeletal localization and neutralization of the SDF-1 -LRB- CXCL12 -RRB- / CXCR4 axis blocks prostate_cancer metastasis and growth in osseous sites in vivo .
15805265	0	SDF-1	21,26	CXCR4	66,71	SDF-1	CXCR4	6387	7852	Gene	Gene	response|compound|START_ENTITY response|nmod|alteration alteration|nmod|signaling signaling|compound|END_ENTITY	p210BCR-ABL inhibits SDF-1 chemotactic response via alteration of CXCR4 signaling and down-regulation of CXCR4 expression .
16005185	0	SDF-1	39,44	CXCR4	45,50	SDF-1	CXCR4	6387	7852	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|dep|signaling	Diverse signaling pathways through the SDF-1 / CXCR4 chemokine axis in prostate_cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis .
16262623	0	SDF-1	4,9	CXCR4	10,15	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	START_ENTITY|dep|pathway pathway|nummod|END_ENTITY	The SDF-1 / CXCR4 pathway and the development of the cerebellar system .
16597663	0	SDF-1	16,21	CXCR4	39,44	SDF-1	CXCR4	6387	7852	Gene	Gene	Localisation|nmod|START_ENTITY END_ENTITY|nsubj|Localisation	Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age_related_macular_degeneration .
16648859	0	SDF-1	32,37	CXCR4	87,92	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	deployment|nmod|START_ENTITY induces|nsubj|deployment induces|nmod|recruitment recruitment|nmod|hemangiocytes hemangiocytes|nummod|+ +|compound|END_ENTITY	Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4 + hemangiocytes .
16702540	0	SDF-1	14,19	CXCR4	131,136	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|modulates modulates|dobj|pattern pattern|nmod|neurons neurons|acl|induced induced|nmod|END_ENTITY	The chemokine SDF-1 / CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4 .
16863903	0	SDF-1	19,24	CXCR4	25,30	SDF-1	CXCR4	6387	7852	Gene	Gene	Mutual|amod|START_ENTITY Mutual|parataxis|stromal stromal|nsubj|interactions interactions|nummod|END_ENTITY	Mutual , reciprocal SDF-1 / CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice .
16974072	0	SDF-1	16,21	CXCR4	22,27	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|parataxis|interaction interaction|nsubj|END_ENTITY	Crucial role of SDF-1 / CXCR4 interaction in the recruitment of transplanted dermal multipotent cells to sublethally irradiated bone marrow .
17046575	0	SDF-1	72,77	CXCR4	142,147	SDF-1	CXCR4	6387	7852	Gene	Gene	stromal_cell-derived_factor-1|appos|START_ENTITY Cloning|dobj|stromal_cell-derived_factor-1 Cloning|parataxis|plays plays|nmod|END_ENTITY	Cloning and characterizing mutated human stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- : C-terminal alpha-helix of SDF-1alpha plays a critical role in CXCR4 activation and signaling , but not in CXCR4 binding affinity .
17049119	0	SDF-1	109,114	CXCR4	115,120	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin_lymphoma by regulating SDF-1 / CXCR4 axis in vitro .
17096920	0	SDF-1	21,26	CXCR4	27,32	SDF-1	CXCR4	6387	7852	Gene	Gene	-LSB-|nmod|START_ENTITY axis|dep|-LSB- axis|nummod|END_ENTITY	-LSB- Research advance on SDF-1 / CXCR4 axis associated with hematological_malignancies : review -RSB- .
17165132	0	SDF-1	28,33	CXCR4	35,40	SDF-1	CXCR4	6387	7852	Gene	Gene	CXCL12|appos|START_ENTITY role|nmod|CXCL12 role|dep|axis axis|nummod|END_ENTITY	The pivotal role of CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis in bone metastasis .
17379424	0	SDF-1	46,51	CXCR4	52,57	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|dep|axis axis|nsubj|END_ENTITY	Beta-catenin is a promising key factor in the SDF-1 / CXCR4 axis on metastasis of pancreatic_cancer .
17463394	0	SDF-1	12,17	CXCR4	18,23	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|axis axis|nummod|END_ENTITY	Role of the SDF-1 / CXCR4 axis in the pathogenesis of lung_injury and fibrosis .
17522382	0	SDF-1	4,9	CXCR4	10,15	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|contributor contributor|nsubj|pair pair|nummod|END_ENTITY	The SDF-1 / CXCR4 ligand/receptor pair is an important contributor to several types of ocular_neovascularization .
17972109	0	SDF-1	14,19	CXCR4	20,25	SDF-1	CXCR4	6387	7852	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of SDF-1 / CXCR4 in injured human kidneys .
17976542	0	SDF-1	8,13	CXCR4	14,19	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|marrow marrow|nsubj|system system|nummod|END_ENTITY	Role of SDF-1 / CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral_infarct .
18206727	0	SDF-1	8,13	CXCR4	14,19	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Altered SDF-1 / CXCR4 axis in patients with primary_myelofibrosis and in the Gata1 low mouse model of the disease .
18310089	0	SDF-1	13,18	CXCR4	47,52	SDF-1	CXCR4	6387	7852	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Bone-derived SDF-1 stimulates IL-6 release via CXCR4 , ERK and NF-kappaB pathways and promotes osteoclastogenesis in human oral_cancer cells .
18426684	0	SDF-1	24,29	CXCR4	30,35	SDF-1	CXCR4	6387	7852	Gene	Gene	review|compound|START_ENTITY review|dep|axis axis|nummod|END_ENTITY	-LSB- Advance of research on SDF-1 / CXCR4 axis and angiogenesis in leukemia -- review -RSB- .
18448868	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|interaction interaction|compound|END_ENTITY	SDF-1 / CXCR4 and VLA-4 interaction regulates homing in Waldenstrom_macroglobulinemia .
18799424	0	SDF-1	69,74	CXCR4	20,25	SDF-1	CXCR4	6387	7852	Gene	Gene	CXCL12|compound|START_ENTITY sulfotyrosine|nmod|CXCL12 sulfotyrosine|nsubj|basis basis|nmod|END_ENTITY	Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1 / CXCL12 .
18997494	0	SDF-1	21,26	CXCR4	27,32	SDF-1	CXCR4	6387	7852	Gene	Gene	role|nmod|START_ENTITY role|parataxis|stem stem|nsubj|axis axis|nummod|END_ENTITY	The critical role of SDF-1 / CXCR4 axis in cancer and cancer stem cells metastasis .
19002187	0	SDF-1	12,17	CXCR4	18,23	SDF-1	CXCR4	6387	7852	Gene	Gene	Blockade|nmod|START_ENTITY Blockade|parataxis|signalling signalling|nsubj|END_ENTITY	Blockade of SDF-1 / CXCR4 signalling inhibits pancreatic_cancer progression in vitro via inactivation of canonical Wnt pathway .
19379577	0	SDF-1	12,17	CXCR4	18,23	SDF-1	CXCR4	6387	7852	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	-LSB- Effects of SDF-1 / CXCR4 on the chemotaxis of cord blood AC133 -LRB- + -RRB- cells -RSB- .
19379578	0	SDF-1	17,22	CXCR4	23,28	SDF-1	CXCR4	6387	7852	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|dep|axis axis|nummod|END_ENTITY	-LSB- Contribution of SDF-1 / CXCR4 axis on proliferation of megakaryocyte co-cultured with human umbilical cord blood-derived stromal cells -RSB- .
19423843	0	SDF-1	18,23	CXCR4	24,29	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|attenuates attenuates|nsubj|axis axis|compound|END_ENTITY	Inhibition of the SDF-1 / CXCR4 axis attenuates neonatal_hypoxia-induced pulmonary_hypertension .
19443644	0	SDF-1	12,17	CXCR4	19,24	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	CXCL12|appos|START_ENTITY CXCL12|dep|axis axis|nummod|END_ENTITY	The CXCL12 -LRB- SDF-1 -RRB- / CXCR4 axis is essential for the development of renal vasculature .
19459330	0	SDF-1	128,133	CXCR4	39,44	SDF-1	CXCR4	6387	7852	Gene	Gene	stem|nmod|START_ENTITY stem|nsubj|Effects Effects|nmod|modification modification|nmod|expression expression|nummod|END_ENTITY	-LSB- Effects of Snail gene modification on CXCR4 expression of human bone mesenchymal stem cells and their capacity of migration to SDF-1 in vitro -RSB- .
19513623	0	SDF-1	12,17	CXCR4	18,23	SDF-1	CXCR4	6387	7852	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|nummod|END_ENTITY	The role of SDF-1 / CXCR4 axis in ovarian_cancer metastasis .
19588204	0	SDF-1	87,92	CXCR4	93,98	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Hepatic stellate cells promote liver metastasis of colon_cancer cells by the action of SDF-1 / CXCR4 axis .
19770040	0	SDF-1	12,17	CXCR4	18,23	SDF-1	CXCR4	399030(Tax:8355)	100192360(Tax:8355)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|parataxis|signaling signaling|nsubj|END_ENTITY	Analysis of SDF-1 / CXCR4 signaling in primordial germ cell migration and survival or differentiation in Xenopus_laevis .
19821487	0	SDF-1	80,85	CXCR4	0,5	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY regulate|xcomp|independent regulate|nsubj|END_ENTITY	CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1 .
19885584	0	SDF-1	57,62	CXCR4	0,5	SDF-1	CXCR4	6387	7852	Gene	Gene	binding|nmod|START_ENTITY follows|dobj|binding follows|nsubj|localization localization|nummod|END_ENTITY	CXCR4 nuclear localization follows binding of its ligand SDF-1 and occurs in metastatic but not primary renal_cell_carcinoma .
20009035	0	SDF-1	78,83	CXCR4	84,89	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	perturbing|dobj|START_ENTITY promotes|advcl|perturbing promotes|parataxis|axis axis|nsubj|END_ENTITY	Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1 : CXCR4 axis .
20118565	0	SDF-1	12,17	CXCR4	18,23	SDF-1	CXCR4	6387	7852	Gene	Gene	Role|nmod|START_ENTITY Role|dep|system system|nummod|END_ENTITY	Role of the SDF-1 / CXCR4 system in myocardial_infarction .
20151462	0	SDF-1	41,46	CXCR4	51,56	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|receptors receptors|compound|END_ENTITY	Induction of myogenic differentiation by SDF-1 via CXCR4 and CXCR7 receptors .
20153802	0	SDF-1	69,74	CXCR4	75,80	SDF-1	CXCR4	6387	7852	Gene	Gene	disrupt|dobj|START_ENTITY cleavage|ccomp|disrupt axis|dep|cleavage axis|nummod|END_ENTITY	Fifth complement cascade protein -LRB- C5 -RRB- cleavage fragments disrupt the SDF-1 / CXCR4 axis : further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells .
20181837	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|contributes contributes|nsubj|END_ENTITY	SDF-1 / CXCR4 contributes to the activation of tip cells and microglia in retinal angiogenesis .
20459090	0	SDF-1	10,15	CXCR4	65,70	SDF-1	CXCR4	6387	7852	Gene	Gene	Targeting|dobj|START_ENTITY CXCL12|dep|Targeting CXCL12|acl:relcl|prevents prevents|dobj|activation activation|nmod|END_ENTITY	Targeting SDF-1 / CXCL12 with a ligand that prevents activation of CXCR4 through structure-based drug design .
20484021	0	SDF-1	8,13	CXCR4	15,20	SDF-1	CXCR4	6387	7852	Gene	Gene	CXCL12|appos|START_ENTITY /|nsubj|CXCL12 /|dobj|pathway pathway|nummod|END_ENTITY	CXCL12 -LRB- SDF-1 -RRB- / CXCR4 pathway in cancer .
20524780	0	SDF-1	52,57	CXCR4	58,63	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	The spleen recruits endothelial progenitor cell via SDF-1 / CXCR4 axis in mice .
20563655	0	SDF-1	40,45	CXCR4	71,76	SDF-1	CXCR4	6387	7852	Gene	Gene	stromal_derived_factor-1|appos|START_ENTITY stromal_derived_factor-1|appos|END_ENTITY	Expression of stromal_derived_factor-1 -LRB- SDF-1 -RRB- and chemokine_receptor -LRB- CXCR4 -RRB- in bone metastasis of renal_carcinoma .
20637871	0	SDF-1	22,27	CXCR4	28,33	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Can inhibition of the SDF-1 / CXCR4 axis eradicate acute_leukemia ?
20859707	0	SDF-1	13,18	CXCR4	19,24	SDF-1	CXCR4	6387	7852	Gene	Gene	roles|nmod|START_ENTITY roles|dep|axis axis|nummod|END_ENTITY	The roles of SDF-1 / CXCR4 axis and its relationship with apoptosis in the myelodysplastic_syndromes .
21215244	0	SDF-1	29,34	CXCR4	36,41	SDF-1	CXCR4	6387	7852	Gene	Gene	CXCL12|appos|START_ENTITY Dysfunctions|nmod|CXCL12 Dysfunctions|parataxis|signaling signaling|nsubj|END_ENTITY	-LSB- Dysfunctions of the CXCL12 -LRB- SDF-1 -RRB- / CXCR4 signaling axis in the WHIM_syndrome and the idiopathic CD4 -LRB- + -RRB- T-cell lymphocytopenia -RSB- .
21443090	0	SDF-1	94,99	CXCR4	100,105	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Adipose-derived stem cells promote gastric_cancer cell growth , migration and invasion through SDF-1 / CXCR4 axis .
21518481	0	SDF-1	10,15	CXCR4	16,21	SDF-1	CXCR4	6387	7852	Gene	Gene	Level|nmod|START_ENTITY Level|dep|END_ENTITY	-LSB- Level of SDF-1 / CXCR4 in children with acute_leukemia and its significance -RSB- .
21556934	0	SDF-1	27,32	CXCR4	33,38	SDF-1	CXCR4	6387	7852	Gene	Gene	behavior|nmod|START_ENTITY behavior|dep|END_ENTITY	The biological behavior of SDF-1 / CXCR4 in patients with myelodysplastic_syndrome .
21567300	0	SDF-1	31,36	CXCR4	74,79	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	_|appos|START_ENTITY _|nsubj|_ _|ccomp|induces induces|nsubj|activation activation|appos|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / chemokine _ -LRB- C-X-C_motif -RRB- _ receptor_4 -LRB- CXCR4 -RRB- axis activation induces intra-islet glucagon-like_peptide-1 -LRB- GLP-1 -RRB- production and enhances beta cell survival .
21587260	0	SDF-1	10,15	CXCR4	16,21	SDF-1	CXCR4	6387	7852	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting SDF-1 / CXCR4 to inhibit tumour vasculature for treatment of glioblastomas .
21618098	0	SDF-1	48,53	CXCR4	54,59	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Pathways implicated in stem cell migration : the SDF-1 / CXCR4 axis .
21752744	0	SDF-1	96,101	CXCR4	102,107	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	homing|nmod|START_ENTITY acts|nmod|homing therapy|acl|acts therapy|parataxis|axis axis|nsubj|END_ENTITY	Dual stem cell therapy after myocardial_infarction acts specifically by enhanced homing via the SDF-1 / CXCR4 axis .
21802140	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|dep|axis axis|nummod|END_ENTITY	SDF-1 / CXCR4 axis in myelodysplastic_syndromes : correlation with angiogenesis and apoptosis .
21821779	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	START_ENTITY|appos|mediates mediates|nsubj|END_ENTITY	SDF-1 / CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury .
21906874	0	SDF-1	70,75	CXCR4	76,81	SDF-1	CXCR4	6387	7852	Gene	Gene	CXCR7|compound|START_ENTITY CXCR7|dep|END_ENTITY	Mesenchymal stromal cells may enhance metastasis of neuroblastoma via SDF-1 / CXCR4 and SDF-1 / CXCR7 signaling .
21909361	0	SDF-1	66,71	CXCR4	72,77	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|dep|axis axis|nummod|END_ENTITY	Osteopontin enhances the expression and activity of MMP-2 via the SDF-1 / CXCR4 axis in hepatocellular_carcinoma cell lines .
22058039	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|modulates modulates|nsubj|axis axis|compound|END_ENTITY	SDF-1 / CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis , migration and cytokine secretion .
22069486	0	SDF-1	91,96	CXCR4	97,102	SDF-1	CXCR4	6387	7852	Gene	Gene	cells|nmod|START_ENTITY harboring|dobj|cells niche|acl|harboring Identification|nmod|niche Identification|parataxis|axis axis|nsubj|END_ENTITY	Identification of hepatic niche harboring human acute_lymphoblastic_leukemic cells via the SDF-1 / CXCR4 axis .
22092795	0	SDF-1	31,36	CXCR4	55,60	SDF-1	CXCR4	6387	7852	Gene	Gene	Stromal_cell-derived_factor_1|appos|START_ENTITY END_ENTITY|nsubj|Stromal_cell-derived_factor_1	Stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- and its receptor CXCR4 in the formation of postburn hypertrophic_scar -LRB- HTS -RRB- .
22146760	0	SDF-1	136,141	CXCR4	142,147	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Transmyocardial drilling revascularization combined with heparinized bFGF-incorporating stent activates resident cardiac stem cells via SDF-1 / CXCR4 axis .
22169298	0	SDF-1	24,29	CXCR4	30,35	SDF-1	CXCR4	6387	7852	Gene	Gene	behavior|nmod|START_ENTITY behavior|dep|END_ENTITY	-LSB- Biological behavior of SDF-1 / CXCR4 in patients with myelodysplastic_syndrome -RSB- .
22417013	0	SDF-1	93,98	CXCR4	0,5	SDF-1	CXCR4	493806(Tax:9685)	493676(Tax:9685)	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role expression|dep|evidence expression|nummod|END_ENTITY	CXCR4 expression in feline mammary_carcinoma cells : evidence of a proliferative role for the SDF-1 / CXCR4 axis .
22417013	0	SDF-1	93,98	CXCR4	99,104	SDF-1	CXCR4	493806(Tax:9685)	493676(Tax:9685)	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role expression|dep|evidence expression|parataxis|axis axis|nsubj|END_ENTITY	CXCR4 expression in feline mammary_carcinoma cells : evidence of a proliferative role for the SDF-1 / CXCR4 axis .
22450749	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|signaling signaling|compound|END_ENTITY	SDF-1 / CXCR4 signaling induces pancreatic_cancer cell invasion and epithelial-mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway .
22451511	0	SDF-1	4,9	CXCR4	10,15	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	The SDF-1 / CXCR4 axis in stem cell preconditioning .
22541097	0	SDF-1	99,104	CXCR4	105,110	SDF-1	CXCR4	6387	7852	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|-RSB- -RSB-|nsubj|axis axis|compound|END_ENTITY	-LSB- Expression of p57kip2 in patients with de novo myelodysplastic_syndrome and its relationship with SDF-1 / CXCR4 axis -RSB- .
22592891	0	SDF-1	54,59	CXCR4	60,65	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Long-term administration of AMD3100 , an antagonist of SDF-1 / CXCR4 signaling , alters fracture repair .
22727731	0	SDF-1	38,43	CXCR4	45,50	SDF-1	CXCR4	6387	7852	Gene	Gene	Role|nmod|START_ENTITY Role|dep|axis axis|nummod|END_ENTITY	Role of the stromal-derived_factor-1 -LRB- SDF-1 -RRB- - CXCR4 axis in the interaction between hepatic stellate cells and cholangiocarcinoma .
22766125	0	SDF-1	31,36	CXCR4	57,62	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY chemokine|nsubj|Expression chemokine|dobj|END_ENTITY	Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during mouse limb muscle development and regeneration .
22767589	0	SDF-1	21,26	CXCR4	27,32	SDF-1	CXCR4	6387	7852	Gene	Gene	insight|nmod|START_ENTITY New|acl|insight New|parataxis|required required|nsubjpass|axis axis|nummod|END_ENTITY	New insight into the SDF-1 / CXCR4 axis in a breast_carcinoma model : hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation .
22767589	0	SDF-1	95,100	CXCR4	27,32	SDF-1	CXCR4	6387	7852	Gene	Gene	model|dep|START_ENTITY axis|nmod|model axis|nummod|END_ENTITY	New insight into the SDF-1 / CXCR4 axis in a breast_carcinoma model : hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation .
22889515	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|involved involved|nsubjpass|signal signal|compound|END_ENTITY	SDF-1 / CXCR4 signal is involved in decreased expression of p57kip2 in de novo MDS patients .
23259294	0	SDF-1	36,41	CXCR4	42,47	SDF-1	CXCR4	6387	7852	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression axis|dep|-LSB- axis|nummod|END_ENTITY	-LSB- The expression and significance of SDF-1 / CXCR4 biological axis in laryngeal_squamous_cell_carcinoma and lymph node metastasize -RSB- .
23289420	0	SDF-1	52,57	CXCR4	0,5	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	CXCL12|compound|START_ENTITY unit|nmod|CXCL12 form|dobj|unit form|nsubj|END_ENTITY	CXCR4 and CXCR7 form a functional receptor unit for SDF-1 / CXCL12 in primary rodent microglia .
23381805	0	SDF-1	119,124	CXCR4	125,130	SDF-1	CXCR4	6387	7852	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting avb3-mediated SDF-1 / CXCR4 signaling .
23544621	0	SDF-1	81,86	CXCR4	87,92	SDF-1	CXCR4	6387	7852	Gene	Gene	stem|nmod|START_ENTITY induces|ccomp|stem stress|acl:relcl|induces stress|parataxis|pathways pathways|nsubj|axis axis|nummod|END_ENTITY	Low-level shear stress induces human mesenchymal stem cell migration through the SDF-1 / CXCR4 axis via MAPK signaling pathways .
23601898	0	SDF-1	91,96	CXCR4	97,102	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Combination of vessel-targeting agents and fractionated radiation therapy : the role of the SDF-1 / CXCR4 pathway .
23710557	0	SDF-1	14,19	CXCR4	20,25	SDF-1	CXCR4	6387	7852	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|stem stem|nsubj|axis axis|nummod|END_ENTITY	Expression of SDF-1 / CXCR4 axis in bone marrow mesenchymal stem cells derived from rheumatoid_arthritis-usual_interstitial_pneumonia .
23740770	0	SDF-1	64,69	CXCR4	58,63	SDF-1	CXCR4	6387	7852	Gene	Gene	complex|compound|START_ENTITY role|dep|complex role|nmod|sulfation sulfation|nmod|dimerization dimerization|nmod|END_ENTITY	The role of tyrosine sulfation in the dimerization of the CXCR4 : SDF-1 complex .
24014104	0	SDF-1	0,5	CXCR4	80,85	SDF-1	CXCR4	6387	7852	Gene	Gene	restores|compound|START_ENTITY angiogenesis|nsubj|restores angiogenesis|nmod|internalization internalization|compound|END_ENTITY	SDF-1 restores angiogenesis synergistically with VEGF upon LDL exposure despite CXCR4 internalization and degradation .
24085800	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|axis axis|compound|END_ENTITY	SDF-1 / CXCR4 axis promotes directional migration of colorectal_cancer cells through upregulation of integrin avb6 .
24196072	0	SDF-1	115,120	CXCR4	121,126	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Small molecule Me6TREN mobilizes hematopoietic stem/progenitor cells by activating MMP-9 expression and disrupting SDF-1 / CXCR4 axis .
24292718	0	SDF-1	25,30	CXCR4	61,66	SDF-1	CXCR4	6387	7852	Gene	Gene	system|compound|START_ENTITY peculiarities|nmod|system peculiarities|parataxis|sing sing|nsubj|END_ENTITY	The peculiarities of the SDF-1 / CXCL12 system : in some cells , CXCR4 and CXCR7 sing solos , in others , they sing duets .
24381939	0	SDF-1	78,83	CXCR4	84,89	SDF-1	CXCR4	6387	7852	Gene	Gene	targeting|dobj|START_ENTITY Enhancing|advcl|targeting END_ENTITY|dep|Enhancing	Enhancing the migration ability of mesenchymal stromal cells by targeting the SDF-1 / CXCR4 axis .
24399074	0	SDF-1	116,121	CXCR4	122,127	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Vandetanib-induced inhibition_of_neuroblastoma cell migration and invasion is associated with downregulation of the SDF-1 / CXCR4 axis and matrix_metalloproteinase_14 .
24416254	0	SDF-1	26,31	CXCR4	51,56	SDF-1	CXCR4	6387	7852	Gene	Gene	Stromal_derived_factor-1|appos|START_ENTITY Stromal_derived_factor-1|dep|END_ENTITY	Stromal_derived_factor-1 -LRB- SDF-1 -RRB- and its receptors CXCR4 and CXCR7 in endometrial_cancer patients .
24505417	0	SDF-1	107,112	CXCR4	113,118	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Inhibition of angiogenesis , fibrosis and thrombosis by tetramethylpyrazine : mechanisms contributing to the SDF-1 / CXCR4 axis .
24626964	0	SDF-1	4,9	CXCR4	10,15	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|axis axis|compound|END_ENTITY	The SDF-1 / CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute_pancreatitis .
24637920	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	START_ENTITY|appos|preserves preserves|nsubj|signaling signaling|compound|END_ENTITY	SDF-1 / CXCR4 signaling preserves microvascular integrity and renal function in chronic_kidney_disease .
24658853	0	SDF-1	4,9	CXCR4	10,15	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|axis axis|compound|END_ENTITY	The SDF-1 / CXCR4 axis induces epithelial mesenchymal transition in hepatocellular_carcinoma .
24695674	0	SDF-1	25,30	CXCR4	31,36	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|nummod|END_ENTITY	An important role of the SDF-1 / CXCR4 axis in chronic skin_inflammation .
24762228	0	SDF-1	31,36	CXCR4	38,43	SDF-1	CXCR4	6387	7852	Gene	Gene	Stromal_cell-derived_factor-1|appos|START_ENTITY Stromal_cell-derived_factor-1|dep|axis axis|nummod|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / CXCR4 axis enhances cellular invasion in ovarian_carcinoma cells via integrin b1 and b3 expressions .
24977448	1	SDF-1	68,73	CXCR4	74,79	SDF-1	CXCR4	6387	7852	Gene	Gene	Role|nmod|START_ENTITY Role|dep|axis axis|nummod|END_ENTITY	Role of the SDF-1 / CXCR4 axis in acute_myeloid_leukaemia -RSB- .
25072364	0	SDF-1	35,40	CXCR4	41,46	SDF-1	CXCR4	6387	7852	Gene	Gene	Alteration|nmod|START_ENTITY Alteration|parataxis|Expression Expression|compound|END_ENTITY	Chemotherapy-induced Alteration of SDF-1 / CXCR4 Expression in Bone Marrow-derived Mesenchymal Stem Cells From Adolescents and Young Adults With Acute_Lymphoblastic_Leukemia .
25130304	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	START_ENTITY|appos|Cells Cells|nsubj|Axis Axis|compound|END_ENTITY	SDF-1 / CXCR4 Axis in Tie2-lineage Cells Including Endothelial Progenitor Cells Contributes to Bone Fracture_Healing .
25150783	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	SDF-1 / CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal_cancer by activation of the Wnt/b-catenin signaling pathway .
25421212	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|dep|Progression Progression|compound|END_ENTITY	SDF-1 / CXCR4 Axis Regulates Cell Cycle Progression and Epithelial-Mesenchymal Transition via Up-regulation of Survivin in Glioblastoma .
25428386	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|signaling signaling|nsubj|END_ENTITY	SDF-1 / CXCR4 signaling up-regulates survivin to regulate human sacral_chondrosarcoma cell cycle and epithelial-mesenchymal transition via ERK and PI3K/AKT pathway .
25775124	0	SDF-1	73,78	CXCR4	79,84	SDF-1	CXCR4	6387	7852	Gene	Gene	Disrupting|dobj|START_ENTITY Migration|acl|Disrupting Migration|parataxis|Axis Axis|nsubj|Signaling Signaling|compound|END_ENTITY	IL-24 Inhibits Lung Cancer Cell Migration and Invasion by Disrupting The SDF-1 / CXCR4 Signaling Axis .
25784988	0	SDF-1	156,161	CXCR4	162,167	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	independent|nmod|START_ENTITY axis|dep|independent axis|nummod|END_ENTITY	Activation of protein kinase C enhanced movement ability and paracrine function of rat bone marrow mesenchymal stem cells partly at least independent of SDF-1 / CXCR4 axis and PI3K/AKT pathway .
25825165	0	SDF-1	93,98	CXCR4	99,104	SDF-1	CXCR4	6387	7852	Gene	Gene	exploitation|nmod|START_ENTITY delivery|dep|exploitation delivery|parataxis|axis axis|nsubj|END_ENTITY	Injectable hydrogel delivery plus preconditioning of mesenchymal stem cells : exploitation of SDF-1 / CXCR4 axis towards enhancing the efficacy of stem cells ' homing .
26026718	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	SDF-1 / CXCR4 promotes F5M2 osteosarcoma cell migration by activating the Wnt/b-catenin signaling pathway .
26074977	0	SDF-1	148,153	CXCR4	154,159	SDF-1	CXCR4	6387	7852	Gene	Gene	Migration|nmod|START_ENTITY Improves|dep|Migration Improves|parataxis|END_ENTITY	Ultrasound-Targeted Microbubble Destruction Improves the Migration and Homing of Mesenchymal Stem Cells after Myocardial_Infarction by Upregulating SDF-1 / CXCR4 : A Pilot Study .
26074989	0	SDF-1	35,40	CXCR4	41,46	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|parataxis|Induced Induced|nsubj|Expression Expression|compound|END_ENTITY	Effects of Astragaloside_IV on the SDF-1 / CXCR4 Expression in Atherosclerosis of apoE -LRB- - / - -RRB- Mice Induced by Hyperlipaemia .
26275042	0	SDF-1	144,149	CXCR4	150,155	SDF-1	CXCR4	6387	7852	Gene	Gene	Axis|compound|START_ENTITY Axis|compound|END_ENTITY	Tetramethylpyrazine -LRB- TMP -RRB- , an Active Ingredient of Chinese Herb Medicine Chuanxiong , Attenuates the Degeneration of Trabecular Meshwork through SDF-1 / CXCR4 Axis .
26300925	0	SDF-1	0,5	CXCR4	6,11	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	START_ENTITY|dep|MSCs MSCs|compound|END_ENTITY	SDF-1 / CXCR4 Axis Promotes MSCs to Repair Liver_Injury Partially through Trans-Differentiation and Fusion with Hepatocytes .
26345294	0	SDF-1	121,126	CXCR4	50,55	SDF-1	CXCR4	6387	7852	Gene	Gene	gradient|compound|START_ENTITY responsiveness|nmod|gradient cells|appos|responsiveness cells|nummod|END_ENTITY	Dimethylsulphoxide -LRB- DMSO -RRB- increases percentage of CXCR4 + hematopoietic stem/progenitor cells , their responsiveness to an SDF-1 gradient , homing capacities and survival .
26345294	0	SDF-1	121,126	CXCR4	50,55	SDF-1	CXCR4	6387	7852	Gene	Gene	gradient|compound|START_ENTITY responsiveness|nmod|gradient cells|appos|responsiveness cells|nummod|END_ENTITY	Dimethylsulphoxide -LRB- DMSO -RRB- increases percentage of CXCR4 + hematopoietic stem/progenitor cells , their responsiveness to an SDF-1 gradient , homing capacities and survival .
26366086	0	SDF-1	12,17	CXCR4	18,23	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of SDF-1 / CXCR4 in the vasculogenesis and remodeling of cerebral_arteriovenous_malformation .
26398409	0	SDF-1	10,15	CXCR4	16,21	SDF-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|parataxis|stem stem|nsubj|axis axis|nummod|END_ENTITY	Effect of SDF-1 / CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal_cord_injury .
26441982	0	SDF-1	37,42	CXCR4	43,48	SDF-1	CXCR4	6387	7852	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|Axis Axis|compound|END_ENTITY	Dipeptidyl_Peptidase-4 Regulation of SDF-1 / CXCR4 Axis : Implications for Cardiovascular_Disease .
26490988	0	SDF-1	4,9	CXCR4	10,15	SDF-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|chemokine chemokine|compound|END_ENTITY	The SDF-1 / CXCR4 chemokine axis in uveal_melanoma cell proliferation and migration .
26578388	0	SDF-1	18,23	CXCR4	24,29	SDF-1	CXCR4	6387	7852	Gene	Gene	CXCR7|compound|START_ENTITY CXCR7|dep|END_ENTITY	Crosstalk between SDF-1 / CXCR4 and SDF-1 / CXCR7 in cardiac stem cell migration .
26851944	0	SDF-1	84,89	CXCR4	90,95	SDF-1	CXCR4	6387	7852	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Cancer-associated fibroblasts promote the progression of endometrial_cancer via the SDF-1 / CXCR4 axis .
27057951	0	SDF-1	110,115	CXCR4	116,121	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Cyclophilin_A modulates bone marrow-derived CD117 -LRB- + -RRB- cells and enhances ischemia-induced angiogenesis via the SDF-1 / CXCR4 axis .
9247593	0	SDF-1	14,19	CXCR4	118,123	SDF-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	attracts|nsubj|START_ENTITY attracts|dobj|precursors precursors|nmod|END_ENTITY	The chemokine SDF-1 , stromal_cell-derived_factor_1 , attracts early stage B cell precursors via the chemokine receptor CXCR4 .
26441982	0	SDF-1	37,42	Dipeptidyl_Peptidase-4	0,22	SDF-1	Dipeptidyl Peptidase-4	6387	1803	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	Dipeptidyl_Peptidase-4 Regulation of SDF-1 / CXCR4 Axis : Implications for Cardiovascular_Disease .
19301256	0	SDF-1	16,21	FGF2	0,4	SDF-1	FGF2	20315(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells .
26093947	0	SDF-1	8,13	G-CSF	147,152	SDF-1	G-CSF	20315(Tax:10090)	100036204(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of SDF-1 -LRB- CXCL12 -RRB- in regulating hematopoietic stem and progenitor cells traffic into the liver during extramedullary hematopoiesis induced by G-CSF , AMD3100 and PHZ .
15235597	0	SDF-1	89,94	HIF-1	70,75	SDF-1	HIF-1	6387	3091	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 .
24845641	0	SDF-1	91,96	HIF-1a	84,90	SDF-1	HIF-1a	20315(Tax:10090)	15251(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	PPARa regulates mobilization and homing of endothelial progenitor cells through the HIF-1a / SDF-1 pathway .
11306951	0	SDF-1	0,5	IL-8	14,18	SDF-1	IL-8	6387	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	SDF-1 induces IL-8 production and transendothelial migration of human cord blood-derived mast cells .
10828007	0	SDF-1	14,19	LFA-1	44,49	SDF-1	LFA-1	6387	3683	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The chemokine SDF-1 activates the integrins LFA-1 , VLA-4 , and VLA-5 on immature human CD34 -LRB- + -RRB- cells : role in transendothelial/stromal migration and engraftment of NOD/SCID mice .
11795258	0	SDF-1	18,23	PBSF	24,28	SDF-1	PBSF	6387	6387	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of chemokine SDF-1 / PBSF and its receptor CXCR4 in blood vessel development .
22552856	0	SDF-1	103,108	PECAM-1	109,116	SDF-1	PECAM-1	6387	5175	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Umbilical cord blood-derived stromal cells regulate megakaryocytic proliferation and migration through SDF-1 / PECAM-1 pathway .
24845641	0	SDF-1	91,96	PPARa	0,5	SDF-1	PPARa	20315(Tax:10090)	19013(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	PPARa regulates mobilization and homing of endothelial progenitor cells through the HIF-1a / SDF-1 pathway .
11209089	0	SDF-1	17,22	SDF-1_receptor	41,55	SDF-1	SDF-1 receptor	6387	7852	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of SDF-1 and expression of SDF-1_receptor on CD34 + cells in mobilized peripheral blood of non-Hodgkin 's _ lymphoma patients .
11489936	0	SDF-1	19,24	TNF-alpha	0,9	SDF-1	TNF-alpha	6387	7124	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	TNF-alpha mediates SDF-1 alpha-induced NF-kappa_B activation and cytotoxic effects in primary astrocytes .
22541097	0	SDF-1	99,104	p57kip2	15,22	SDF-1	p57kip2	6387	1028	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of p57kip2 in patients with de novo myelodysplastic_syndrome and its relationship with SDF-1 / CXCR4 axis -RSB- .
15157323	0	SDF-1	52,57	stroma_cell_drived_factor_1	23,50	SDF-1	stroma cell drived factor 1	6387	6387	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	-LSB- Inhibiting effects of stroma_cell_drived_factor_1 -LRB- SDF-1 -RRB- on proliferation of human acute_myelocytic_leukemia cell HL-60 -RSB- .
21041659	0	SDF-1	54,59	stromal_cell-derived_factor-1	23,52	SDF-1	stromal cell-derived factor-1	6387	6387	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Autocrine TGF-beta and stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts .
23599431	0	SDF-1	93,98	stromal_cell-derived_factor-1	62,91	SDF-1	stromal cell-derived factor-1	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Induction of C-X-C_chemokine_receptor_type_7 -LRB- CXCR7 -RRB- switches stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- signaling and phagocytic activity in macrophages linked to atherosclerosis .
18709383	0	SDF-1	47,52	stromal_cell-derived_factor_1	16,45	SDF-1	stromal cell-derived factor 1	24772(Tax:10116)	24772(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- expression in microvasculature endothelial cells in retinal_ischemia-reperfusion_injury .
18928845	0	SDF-1	49,54	stromal_cell-derived_factor_1	18,47	SDF-1	stromal cell-derived factor 1	6387	6387	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- in inflamed human dental pulp .
24114538	0	SDF-1	43,48	stromal_cell-derived_factor_1	12,41	SDF-1	stromal cell-derived factor 1	6387	6387	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulated stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- expression and its interaction with CXCR4 contribute to the pathogenesis of severe pterygia .
15998835	0	SDF-1-CXCR4	33,44	RGS16	0,5	SDF-1-CXCR4	RGS16	6387;7852	6004	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes .
11209089	0	SDF-1_receptor	41,55	CD34	59,63	SDF-1 receptor	CD34	7852	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Plasma levels of SDF-1 and expression of SDF-1_receptor on CD34 + cells in mobilized peripheral blood of non-Hodgkin 's _ lymphoma patients .
11209089	0	SDF-1_receptor	41,55	SDF-1	17,22	SDF-1 receptor	SDF-1	7852	6387	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of SDF-1 and expression of SDF-1_receptor on CD34 + cells in mobilized peripheral blood of non-Hodgkin 's _ lymphoma patients .
16284526	0	SDF1	58,62	CXCL12	50,56	SDF1	CXCL12	6387	6387	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Risk for HIV-1_infection associated with a common CXCL12 -LRB- SDF1 -RRB- polymorphism and CXCR4 variation in an African population .
21179442	0	SDF1	34,38	CXCL12	26,32	SDF1	CXCL12	6387	6387	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MiR-886-3p down regulates CXCL12 -LRB- SDF1 -RRB- expression in human marrow stromal cells .
17077327	0	SDF1	56,60	FGF2	0,4	SDF1	FGF2	6387	2247	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc .
24586072	0	SDF1	45,49	SRC1	12,16	SDF1	SRC1	6387	8648	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium .
7490086	0	SDF1	83,87	stromal_cell-derived_factor_1	52,81	SDF1	stromal cell-derived factor 1	6387	6387	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and chromosomal localization of the human stromal_cell-derived_factor_1 -LRB- SDF1 -RRB- gene .
8621257	0	SDGF	58,62	schwannoma-derived_growth_factor	24,56	SDGF	schwannoma-derived growth factor	29183(Tax:10116)	29183(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Increased expression of schwannoma-derived_growth_factor -LRB- SDGF -RRB- mRNA in rat tumor cells : involvement of SDGF in the growth promotion of rat gliomas .
313949	0	SDH	48,51	20_alpha_hydroxysteroid_dehydrogenase	0,37	SDH	20 alpha hydroxysteroid dehydrogenase	231691(Tax:10090)	105349(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	20_alpha_hydroxysteroid_dehydrogenase -LRB- 20 alpha SDH -RRB- activity in New Zealand mice T lymphocytes and bone marrow cells : effect of age , sex , and castration .
2384736	0	SDH	29,32	succinate_dehydrogenase	4,27	SDH	succinate dehydrogenase	6390	6390	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Low succinate_dehydrogenase -LRB- SDH -RRB- activity in a patient with a hereditary_myopathy with paroxysmal myoglobinuria .
4465902	0	SDH	50,53	succinic_dehydrogenase	26,48	SDH	succinic dehydrogenase	6390	6390	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The effect of malonate on succinic_dehydrogenase -LRB- SDH -RRB- activity during the multiplication of influenza and herpes viruses in the embryonate hen egg .
6425114	1	SDH	144,147	succinic_dehydrogenase	120,142	SDH	succinic dehydrogenase	6390	6390	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	I. Effect of T4 and thiourea on succinic_dehydrogenase -LRB- SDH -RRB- activity and protein content .
26749241	0	SDHAF1	16,22	SDHB	69,73	SDHAF1	SDHB	644096	6390	Gene	Gene	Mutations|nsubj|START_ENTITY Mutations|nmod|END_ENTITY	Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB .
26749241	0	SDHB	69,73	SDHAF1	16,22	SDHB	SDHAF1	6390	644096	Gene	Gene	Mutations|nmod|START_ENTITY Mutations|nsubj|END_ENTITY	Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB .
22804613	0	SDHB	43,47	succinate_dehydrogenase_subunit_B	8,41	SDHB	succinate dehydrogenase subunit B	6390	6390	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of succinate_dehydrogenase_subunit_B -LRB- SDHB -RRB- expression is limited to a distinctive subset of gastric wild-type gastrointestinal_stromal_tumours : a comprehensive genotype-phenotype correlation study .
23612575	0	SDHD	44,48	succinate_dehydrogenase	57,80	SDHD	succinate dehydrogenase	6392	6390	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Analysis of all subunits , SDHA , SDHB , SDHC , SDHD , of the succinate_dehydrogenase complex in KIT/PDGFRA wild-type GIST .
21792967	0	SDHD	65,69	succinate_dehydrogenase_subunit_D	30,63	SDHD	succinate dehydrogenase subunit D	6392	6392	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Is the c. 3G > C mutation in the succinate_dehydrogenase_subunit_D -LRB- SDHD -RRB- gene due to a founder effect in Chinese head_and_neck_paraganglioma patients ?
7664278	0	SDI-1	178,183	Cip-1	184,189	SDI-1	Cip-1	1026	1026	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Ultraviolet B light induces G1_arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1 / SDI-1 / Cip-1 protein .
8846917	0	SDI-1	108,113	p21	91,94	SDI-1	p21	1026	1026	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	CCAAT/enhancer-binding protein alpha -LRB- C/EBP _ alpha -RRB- inhibits cell proliferation through the p21 -LRB- WAF-1 / CIP-1 / SDI-1 -RRB- protein .
19631636	0	SDN-1	0,5	syndecan	6,14	SDN-1	syndecan	181259(Tax:6239)	181259(Tax:6239)	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	SDN-1 / syndecan regulates growth factor signaling in distal tip cell migrations in C. _ elegans .
26311046	0	SDR34C1	36,43	DHRS7	29,34	SDR34C1	DHRS7	51635	51635	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for the dehydrogenase DHRS7 -LRB- SDR34C1 -RRB- in prostate_cancer .
10330397	0	SEC24	10,15	LST1	0,4	SEC24	LST1	854697(Tax:4932)	856498(Tax:4932)	Gene	Gene	homologue|compound|START_ENTITY homologue|nsubj|END_ENTITY	LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum .
10652336	0	SECTM1	53,59	K12	48,51	SECTM1	K12	6398	3859	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of CD7 as a cognate of the human K12 -LRB- SECTM1 -RRB- protein .
17142478	0	SEF	0,3	PIE1	84,88	SEF	PIE1	833676(Tax:3702)	820463(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SEF , a new protein required for flowering repression in Arabidopsis , interacts with PIE1 and ARP6 .
25578559	0	SEI-1	42,47	p21	48,51	SEI-1	p21	55942(Tax:10090)	12575(Tax:10090)	Gene	Gene	/|amod|START_ENTITY END_ENTITY|amod|/	KLF10 affects pancreatic function via the SEI-1 / p21 -LRB- Cip1 -RRB- pathway .
9006895	0	SEK-1	85,90	Actin-binding_protein-280	0,25	SEK-1	Actin-binding protein-280	6416	2318	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Actin-binding_protein-280 binds the stress-activated_protein_kinase -LRB- SAPK -RRB- activator SEK-1 and is required for tumor_necrosis_factor-alpha activation of SAPK in melanoma cells .
11707464	0	SEK1	44,48	Akt	0,3	SEK1	Akt	6416	207	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Akt -LRB- protein kinase B -RRB- negatively regulates SEK1 by means of protein phosphorylation .
7997270	0	SEK1	88,92	MEKK1	49,54	SEK1	MEKK1	6416	4214	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 .
9043078	0	SEL-1	39,44	LIN-12	70,76	SEL-1	LIN-12	179720(Tax:6239)	176282(Tax:6239)	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Structure , function , and expression of SEL-1 , a negative regulator of LIN-12 and GLP-1 in C. _ elegans .
23154983	0	SEL-10	0,6	LIN-45	54,60	SEL-10	LIN-45	179878(Tax:6239)	177436(Tax:6239)	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	SEL-10 / Fbw7-dependent negative feedback regulation of LIN-45 / Braf signaling in C. _ elegans via a conserved phosphodegron .
12354302	0	SEL-10	0,6	presenilin_1	22,34	SEL-10	presenilin 1	55294	5663	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SEL-10 interacts with presenilin_1 , facilitates its ubiquitination , and alters A-beta peptide production .
17215302	0	SEL-2	0,5	Notch	83,88	SEL-2	Notch	175606(Tax:6239)	176282(Tax:6239)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	SEL-2 , the C. _ elegans neurobeachin/LRBA homolog , is a negative regulator of lin-12 / Notch activity and affects endosomal traffic in polarized epithelial cells .
17043138	0	SEL1L	0,5	Hrd3p	30,35	SEL1L	Hrd3p	6400	850904(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	SEL1L , the homologue of yeast Hrd3p , is involved in protein dislocation from the mammalian ER .
19948214	0	SELP	49,53	P-selectin	37,47	SELP	P-selectin	6403	6403	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of a large deletion in the P-selectin -LRB- SELP -RRB- gene .
17661913	0	SELS	33,37	selenoprotein_S	16,31	SELS	selenoprotein S	55829	55829	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of the selenoprotein_S -LRB- SELS -RRB- gene -105 G > A promoter polymorphism in inflammatory_bowel_disease and regulation of SELS gene expression in intestinal inflammation .
20619427	0	SELS	35,39	selenoprotein_S	18,33	SELS	selenoprotein S	55829	55829	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the selenoprotein_S -LRB- SELS -RRB- gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors .
9927667	0	SEM1	0,4	Dss1	75,79	SEM1	Dss1	851967(Tax:4932)	855331(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	SEM1 , a homologue of the split hand/split foot malformation candidate gene Dss1 , regulates exocytosis and pseudohyphal differentiation in yeast .
21059704	0	SEMA3A	74,80	NRP1	100,104	SEMA3A	NRP1	20346(Tax:10090)	18186(Tax:10090)	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Defective gonadotropin-releasing_hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2 : implications for the aetiology of hypogonadotropic_hypogonadism .
18985860	0	SEMA3B	77,83	IGFBP-6	18,25	SEMA3B	IGFBP-6	7869	3489	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3B .
26053665	0	SEMA3C	21,27	NRP1	50,54	SEMA3C	NRP1	20348(Tax:10090)	18186(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation .
25095981	0	SEMA4b	0,6	MMP9	16,20	SEMA4b	MMP9	10509	4318	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	SEMA4b inhibits MMP9 to prevent metastasis of non-small_cell_lung_cancer .
16436660	0	SEMA6A	23,29	interferon-gamma	44,60	SEMA6A	interferon-gamma	57556	3458	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations .
11350127	0	SEMA6B	26,32	semaphorin_6B	6,19	SEMA6B	semaphorin 6B	10501	10501	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Human semaphorin_6B -LSB- -LRB- HSA -RRB- SEMA6B -RSB- , a novel human class 6 semaphorin gene : alternative splicing and all-trans-retinoic_acid-dependent downregulation in glioblastoma cell lines .
18474224	0	SENP1	88,93	PML	76,79	SENP1	PML	29843	5371	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction .
26369384	0	SENP2	0,5	MMP13	16,21	SENP2	MMP13	59343	4322	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	SENP2 regulates MMP13 expression in a bladder_cancer cell line through SUMOylation of TBL1/TBLR1 .
20924358	0	SENP3	55,60	CHIP	83,87	SENP3	CHIP	26168	358	Gene	Gene	START_ENTITY|nmod|interactions interactions|nmod|END_ENTITY	Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90 .
18799455	0	SENP6	89,94	SENP7	23,28	SENP6	SENP7	26054	57337	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|domain domain|compound|END_ENTITY	Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7 .
18799455	0	SENP7	23,28	SENP6	89,94	SENP7	SENP6	57337	26054	Gene	Gene	domain|compound|START_ENTITY Structure|nmod|domain Structure|nmod|END_ENTITY	Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7 .
23209320	0	SENP8	49,54	deneddylase-1	35,48	SENP8	deneddylase-1	123228	123228	Gene	Gene	role|parataxis|START_ENTITY role|nmod|END_ENTITY	Central role for endothelial human deneddylase-1 / SENP8 in fine-tuning the vascular inflammatory response .
18047794	0	SEPT12	0,6	SEPT6	22,27	SEPT12	SEPT6	124404	23157	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells .
18385322	0	SEPT5	58,63	Cyclin-dependent_kinase_5	0,25	SEPT5	Cyclin-dependent kinase 5	5413	1020	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cyclin-dependent_kinase_5 phosphorylation of human septin SEPT5 -LRB- hCDCrel-1 -RRB- modulates exocytosis .
18047794	0	SEPT6	22,27	SEPT12	0,6	SEPT6	SEPT12	23157	124404	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells .
11809673	0	SEPTIN6	0,7	Septin6	36,43	SEPTIN6	Septin6	23157	56526(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	SEPTIN6 , a human homologue to mouse Septin6 , is fused to MLL in infant acute_myeloid_leukemia with complex_chromosomal_abnormalities involving 11q23 and Xq24 .
24807223	0	SERCA	73,78	Seipin	0,6	SERCA	Seipin	49297(Tax:7227)	31245(Tax:7227)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Seipin promotes adipose tissue fat storage through the ER Ca - ATPase SERCA .
25547066	0	SERCA1	64,70	ATPase	47,53	SERCA1	ATPase	487	1769	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Rutin stimulates sarcoplasmic reticulum Ca -LRB- 2 + -RRB- - ATPase activity -LRB- SERCA1 -RRB- and protects SERCA1 from peroxynitrite mediated injury .
9575189	0	SERCA1	37,43	Sarcolipin	0,10	SERCA1	Sarcolipin	100037716(Tax:9986)	100009246(Tax:9986)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Sarcolipin regulates the activity of SERCA1 , the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2 + - ATPase .
18562801	0	SERCA2	25,31	Calumenin	0,9	SERCA2	Calumenin	29693(Tax:10116)	64366(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Calumenin interacts with SERCA2 in rat cardiac sarcoplasmic reticulum .
18971376	0	SERCA2	48,54	HAX-1	27,32	SERCA2	HAX-1	488	10456	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The anti-apoptotic protein HAX-1 interacts with SERCA2 and regulates its protein levels to promote cell survival .
15829561	0	SERCA2	15,21	PYK2	0,4	SERCA2	PYK2	29693(Tax:10116)	50646(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes .
12818568	0	SERCA2	35,41	Sp1	21,24	SERCA2	Sp1	29693(Tax:10116)	24790(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor Sp1 regulates SERCA2 gene expression in pressure-overloaded hearts : a study using in vivo direct gene transfer into living myocardium .
14613864	0	SERCA2	81,87	Sp1	0,3	SERCA2	Sp1	488	6667	Gene	Gene	promoter|compound|START_ENTITY trans-activation|nmod|promoter required|nmod|trans-activation required|nsubjpass|factors factors|compound|END_ENTITY	Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes .
10525666	0	SERCA3	86,92	ATPase	71,77	SERCA3	ATPase	489	1769	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence variants of the sarco -LRB- endo -RRB- plasmic reticulum Ca -LRB- 2 + -RRB- - transport ATPase 3 gene -LRB- SERCA3 -RRB- in Caucasian type II diabetic patients -LRB- UK Prospective Diabetes Study 48 -RRB- .
8779840	0	SERCA_2	14,21	thyroid_hormone	36,51	SERCA 2	thyroid hormone	396446(Tax:9031)	396436(Tax:9031)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Regulation of SERCA_2 expression by thyroid_hormone in cultured chick embryo cardiomyocytes .
15592873	0	SERK1	16,21	AtCDC48	60,67	SERK1	AtCDC48	843513(Tax:3702)	820142(Tax:3702)	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The Arabidopsis SERK1 protein interacts with the AAA-ATPase AtCDC48 , the 14-3-3 protein GF14lambda and the PP2C phosphatase KAPP .
20109307	0	SERPINA1	21,29	Alpha-1-Antitrypsin	31,50	SERPINA1	Alpha-1-Antitrypsin	5265	5265	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the SERPINA1 -LRB- Alpha-1-Antitrypsin -RRB- gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy .
20170533	0	SERPINA1	87,95	alpha-1_antitrypsin	66,85	SERPINA1	alpha-1 antitrypsin	5265	5265	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prevalence of genetic polymorphisms in the promoter region of the alpha-1_antitrypsin -LRB- SERPINA1 -RRB- gene in chronic_liver_disease : a case control study .
26158350	0	SERPINA1	0,8	estrogen_receptor	21,38	SERPINA1	estrogen receptor	5265	2099	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	SERPINA1 is a direct estrogen_receptor target gene and a predictor of survival in breast_cancer patients .
15718509	0	SERPINA3	30,38	Alpha1-antichymotrypsin	0,23	SERPINA3	Alpha1-antichymotrypsin	12	12	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alpha1-antichymotrypsin gene -LRB- SERPINA3 -RRB- A/T polymorphism as a risk factor for aneurysmal_subarachnoid_hemorrhage .
16968986	0	SERPINA3	68,76	alpha-1-antichymotrypsin	42,66	SERPINA3	alpha-1-antichymotrypsin	12	12	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The alanine/threonine polymorphism of the alpha-1-antichymotrypsin -LRB- SERPINA3 -RRB- gene and ruptured intracranial_aneurysms in the Japanese population .
26497600	0	SERPINB12	0,9	Granzyme_A	41,51	SERPINB12	Granzyme A	89777	3001	Gene	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|nmod|END_ENTITY	SERPINB12 Is a Slow-Binding Inhibitor of Granzyme_A and Hepsin .
21723253	0	SERPINB13	0,9	RUNX1	21,26	SERPINB13	RUNX1	5275	861	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	SERPINB13 is a novel RUNX1 target gene .
24809782	0	SERPINB3	0,8	TGF-b1	28,34	SERPINB3	TGF-b1	6317	7040	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	SERPINB3 is associated with TGF-b1 and cytoplasmic b-catenin expression in hepatocellular_carcinomas with poor prognosis .
20212457	0	SERPINB3	0,8	TGF-beta	19,27	SERPINB3	TGF-beta	6317	7040	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	SERPINB3 modulates TGF-beta expression in chronic_liver_disease .
24809782	0	SERPINB3	0,8	b-catenin	51,60	SERPINB3	b-catenin	6317	1499	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	SERPINB3 is associated with TGF-b1 and cytoplasmic b-catenin expression in hepatocellular_carcinomas with poor prognosis .
19387820	0	SERPINE1	60,68	INSR	54,58	SERPINE1	INSR	5054	3643	Gene	Gene	START_ENTITY|nsubj|polymorphisms polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of FSHR , CYP17 , CYP1A1 , CAPN10 , INSR , SERPINE1 genes in adolescent girls with polycystic_ovary_syndrome .
20356416	0	SERPINE1	82,90	PAI-1	92,97	SERPINE1	PAI-1	5054	5054	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	`` Hypoxia-induced down-regulation of microRNA-449a / b impairs control over targeted SERPINE1 -LRB- PAI-1 -RRB- mRNA - a mechanism involved in SERPINE1 -LRB- PAI-1 -RRB- overexpression '' .
21375729	0	SERPINE1	81,89	PAI-1	91,96	SERPINE1	PAI-1	5054	5054	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Hypoxia-induced down-regulation of microRNA-449a / b impairs control over targeted SERPINE1 -LRB- PAI-1 -RRB- mRNA - a mechanism involved in SERPINE1 -LRB- PAI-1 -RRB- overexpression .
24249967	0	SERPINE1	0,8	PAI-1	10,15	SERPINE1	PAI-1	5054	5054	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	SERPINE1 , PAI-1 protein coding gene , methylation levels and epigenetic relationships with adiposity_changes_in_obese_subjects with metabolic_syndrome features under dietary restriction .
22798504	0	SERPINE1	48,56	plasminogen_activator_inhibitor-1	13,46	SERPINE1	plasminogen activator inhibitor-1	5054	5054	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Influence of plasminogen_activator_inhibitor-1 -LRB- SERPINE1 -RRB- 4G/5G polymorphism on circulating SERPINE-1 antigen expression in HCC associated with viral_infection .
26305372	0	SERPINE2	0,8	MMP-13	32,38	SERPINE2	MMP-13	5270	4322	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	SERPINE2 Inhibits IL-1a-Induced MMP-13 Expression in Human Chondrocytes : Involvement of ERK/NF-kB/AP -1 Pathways .
26305372	0	SERPINE2	0,8	MMP-13	32,38	SERPINE2	MMP-13	5270	4322	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	SERPINE2 Inhibits IL-1a-Induced MMP-13 Expression in Human Chondrocytes : Involvement of ERK/NF-kB/AP -1 Pathways .
17656111	0	SERPINF2	47,55	alpha_2-antiplasmin	26,45	SERPINF2	alpha 2-antiplasmin	5345	5345	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Impact of Triton_X-100 on alpha_2-antiplasmin -LRB- SERPINF2 -RRB- activity in solvent/detergent-treated plasma .
18758157	0	SERPING1	34,42	C1INH	27,32	SERPING1	C1INH	710	710	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutational spectrum of the C1INH -LRB- SERPING1 -RRB- gene in patients with hereditary_angioedema .
25954931	0	SERT	48,52	Serotonin_Transporter	25,46	SERT	Serotonin Transporter	6532	6532	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|compound|END_ENTITY	Mechanisms of Intestinal Serotonin_Transporter -LRB- SERT -RRB- Upregulation by TGF-b1 Induced Non-Smad Pathways .
9878762	0	SERT	23,27	Serotonin_transporter	0,21	SERT	Serotonin transporter	25553(Tax:10116)	25553(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Serotonin_transporter -LRB- SERT -RRB- mRNA and binding site densities in male rat brain affected by sex steroids .
25954931	0	SERT	48,52	TGF-b1	70,76	SERT	TGF-b1	6532	7040	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Mechanisms of Intestinal Serotonin_Transporter -LRB- SERT -RRB- Upregulation by TGF-b1 Induced Non-Smad Pathways .
12660809	0	SERT	62,66	serotonin_reuptake_transporter	30,60	SERT	serotonin reuptake transporter	6532	6532	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Ovarian steroid regulation of serotonin_reuptake_transporter -LRB- SERT -RRB- binding , distribution , and function in female macaques .
16432527	0	SERT	45,49	serotonin_transporter	22,43	SERT	serotonin transporter	6532	6532	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Allelic expression of serotonin_transporter -LRB- SERT -RRB- mRNA in human pons : lack of correlation with the polymorphism SERTLPR .
21093224	0	SERT	118,122	serotonin_transporter	95,116	SERT	serotonin transporter	15567(Tax:10090)	15567(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Cerebral metabolic responses to 5-HT2A / C receptor activation in mice with genetically modified serotonin_transporter -LRB- SERT -RRB- expression .
21129470	0	SERT	99,103	serotonin_transporter	76,97	SERT	serotonin transporter	25553(Tax:10116)	25553(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Bacopa monniera leaf extract up-regulates tryptophan hydroxylase -LRB- TPH2 -RRB- and serotonin_transporter -LRB- SERT -RRB- expression : implications in memory formation .
23217646	0	SERT	38,42	serotonin_transporter	10,31	SERT	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Increased serotonin_transporter gene -LRB- SERT -RRB- DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood : a longitudinal study of discordant monozygotic twins .
24075737	0	SERT	43,47	serotonin_transporter	20,41	SERT	serotonin transporter	6532	6532	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association between serotonin_transporter -LRB- SERT -RRB- gene polymorphism and idiopathic_pulmonary_arterial_hypertension : a meta-analysis and review of the literature .
24138674	0	SERT	50,54	serotonin_transporter	27,48	SERT	serotonin transporter	6532	6532	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of platelet serotonin_transporter -LRB- SERT -RRB- in human obesity .
22177971	0	SERT	52,56	serotonin_transporter_protein	21,50	SERT	serotonin transporter protein	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the serotonin_transporter_protein -LRB- SERT -RRB- gene in patients with pulmonary_arterial_hypertension .
15939518	0	SERTPR	62,68	Serotonin_Transporter	17,38	SERTPR	Serotonin Transporter	6532	6532	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	The influence of Serotonin_Transporter Promoter Polymorphism -LRB- SERTPR -RRB- and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments .
26771712	0	SESN2	34,39	Activating_Transcription_Factor_4	64,97	SESN2	Activating Transcription Factor 4	83667	468	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Mitochondrial dysfunction induces SESN2 gene expression through Activating_Transcription_Factor_4 .
20164195	0	SESTD1	33,39	TRPC4	106,111	SESTD1	TRPC4	91404	7223	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5 .
10771115	0	SET	82,85	serotonin_transporter	59,80	SET	serotonin transporter	6532	6532	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Involvement of the actin cytoskeleton in the regulation of serotonin_transporter -LRB- SET -RRB- activity : possible mechanism underlying SET regulation by protein kinase C .
20862685	0	SET-1A	36,42	cyclooxygenase_2	68,84	SET-1A	cyclooxygenase 2	9739	5743	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase_2 and inducible nitric_oxide synthase expression in human osteoarthritis chondrocytes .
23870121	0	SET1	0,4	p53	107,110	SET1	p53	9739	7157	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	SET1 and p300 act synergistically , through coupled histone modifications , in transcriptional activation by p53 .
26581161	0	SET1A	0,5	CUDR	22,26	SET1A	CUDR	9739	652995	Gene	Gene	Cooperates|compound|START_ENTITY Cooperates|nmod|END_ENTITY	SET1A Cooperates With CUDR to Promote Liver_Cancer Growth and Hepatocyte-like Stem Cell Malignant Transformation Epigenetically .
25479749	0	SET7/9	0,6	LIN28A	46,52	SET7/9	LIN28A	80854	79727	Gene	Gene	Methylation|compound|START_ENTITY Methylation|nmod|END_ENTITY	SET7/9 Methylation of the Pluripotency Factor LIN28A Is a Nucleolar Localization Mechanism that Blocks let-7 Biogenesis in Human ESCs .
18260647	0	SET7/9	170,176	p53	118,121	SET7/9	p53	80854	7157	Gene	Gene	methylation|nmod|START_ENTITY methylation|compound|END_ENTITY	Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases : transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9 .
17233820	0	SETBP1	47,53	SET_binding_protein_1	24,45	SETBP1	SET binding protein 1	26040	26040	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Fusion of NUP98 and the SET_binding_protein_1 -LRB- SETBP1 -RRB- gene in a paediatric acute_T_cell_lymphoblastic_leukaemia with t -LRB- 11 ; 18 -RRB- -LRB- p15 ; q12 -RRB- .
24166983	0	SETD2	54,59	BAP1	48,52	SETD2	BAP1	29072	8314	Gene	Gene	KDM6A|appos|START_ENTITY KDM6A|appos|END_ENTITY	Clinical and pathological impact of VHL , PBRM1 , BAP1 , SETD2 , KDM6A , and JARID1c in clear_cell_renal_cell_carcinoma .
24166983	0	SETD2	54,59	PBRM1	41,46	SETD2	PBRM1	29072	55193	Gene	Gene	KDM6A|appos|START_ENTITY KDM6A|appos|END_ENTITY	Clinical and pathological impact of VHL , PBRM1 , BAP1 , SETD2 , KDM6A , and JARID1c in clear_cell_renal_cell_carcinoma .
21131967	0	SETD6	48,53	RelA	40,44	SETD6	RelA	79918	5970	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Lysine methylation of the NF-kB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kB signaling .
26707641	0	SETD8	65,70	MicroRNA-127-3p	0,15	SETD8	MicroRNA-127-3p	387893	100302165	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells .
26949019	0	SETDB1	0,6	FosB	16,20	SETDB1	FosB	9869	2354	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	SETDB1 mediated FosB expression increases the cell proliferation rate during anticancer drug therapy .
25070049	0	SETDB1	65,71	MiR-7	0,5	SETDB1	MiR-7	9869	10859	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	MiR-7 , inhibited indirectly by lincRNA HOTAIR , directly inhibits SETDB1 and reverses the EMT of breast_cancer stem cells by downregulating the STAT3 pathway .
21170338	0	SETDB1	46,52	ZNF274	0,6	SETDB1	ZNF274	9869	10782	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	ZNF274 recruits the histone methyltransferase SETDB1 to the 3 ' ends of ZNF genes .
24565839	0	SETDB1	19,25	p53	0,3	SETDB1	p53	9869	7157	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	p53 down-regulates SETDB1 gene expression during paclitaxel induced-cell death .
24607956	0	SETMAR	56,62	Metnase	64,71	SETMAR	Metnase	6419	6419	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Delineation of known and new transcript variants of the SETMAR -LRB- Metnase -RRB- gene and the expression profile in hematologic_neoplasms .
18663494	0	SETX	58,62	senataxin	47,56	SETX	senataxin	23064	23064	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and characterisation of a large senataxin -LRB- SETX -RRB- gene duplication in ataxia_with_ocular_apraxia_type_2 -LRB- AOA2 -RRB- .
19162039	0	SET_and_MYND_domain_containing_1	41,73	Hepatoma-derived_growth_factor	0,30	SET and MYND domain containing 1	Hepatoma-derived growth factor	150572	3068	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Hepatoma-derived_growth_factor represses SET_and_MYND_domain_containing_1 gene expression through interaction with C-terminal binding protein .
23749797	0	SET_binding_factor_1	0,20	SBF1	22,26	SET binding factor 1	SBF1	6305	6305	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	SET_binding_factor_1 -LRB- SBF1 -RRB- mutation causes Charcot-Marie-Tooth_disease_type_4B3 .
15304601	0	SET_binding_factor_2	0,20	SBF2	22,26	SET binding factor 2	SBF2	81846	81846	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	SET_binding_factor_2 -LRB- SBF2 -RRB- mutation causes CMT4B with juvenile onset glaucoma .
17233820	0	SET_binding_protein_1	24,45	SETBP1	47,53	SET binding protein 1	SETBP1	26040	26040	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fusion of NUP98 and the SET_binding_protein_1 -LRB- SETBP1 -RRB- gene in a paediatric acute_T_cell_lymphoblastic_leukaemia with t -LRB- 11 ; 18 -RRB- -LRB- p15 ; q12 -RRB- .
11782418	0	SEUSS	0,5	LEUNIG	111,117	SEUSS	LEUNIG	840981(Tax:3702)	829390(Tax:3702)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	SEUSS , a member of a novel family of plant regulatory proteins , represses floral homeotic gene expression with LEUNIG .
19047046	5	SF	889,891	NF-kappaB	907,916	SF	NF-kappaB	15234(Tax:10090)	18033(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Src enhanced basal and SF stimulated NF-kappaB activity and SF protection against ADR , in a manner dependent upon its kinase and Src homology 3 domains ; and endogenous Src was required for SF stimulation of NF-kappaB activity and cell protection .
9888512	0	SF-1	0,4	ACTH_receptor	53,66	SF-1	ACTH receptor	7536	4158	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	SF-1 and the transcriptional regulation of the human ACTH_receptor gene .
8806624	0	SF-1	44,48	Ad4bp	37,42	SF-1	Ad4bp	7536	2516	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Structural characterization of human Ad4bp -LRB- SF-1 -RRB- gene .
18182853	0	SF-1	45,49	EID-1	0,5	SF-1	EID-1	7536	23741	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	EID-1 interacts with orphan nuclear receptor SF-1 and represses its transactivation .
26386639	0	SF-1	80,84	GATA-4	73,79	SF-1	GATA-4	22668(Tax:10090)	14463(Tax:10090)	Gene	Gene	factors|compound|START_ENTITY factors|compound|END_ENTITY	Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4 / SF-1 transcription factors .
25896302	0	SF-1	17,21	LRH-1	0,5	SF-1	LRH-1	7536	2494	Gene	Gene	Deficiency|compound|START_ENTITY Deficiency|compound|END_ENTITY	LRH-1 May Rescue SF-1 Deficiency for Steroidogenesis : An in vitro and in vivo Study .
9165127	0	SF-1	21,25	Mullerian_Inhibiting_Substance	68,98	SF-1	Mullerian Inhibiting Substance	7536	268	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	The nuclear receptor SF-1 mediates sexually dimorphic expression of Mullerian_Inhibiting_Substance , in vivo .
22474171	0	SF-1	112,116	NR5A1	105,110	SF-1	NR5A1	7536	2516	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Testosterone production during puberty in two 46 , XY patients with disorders_of_sex_development and novel NR5A1 -LRB- SF-1 -RRB- mutations .
23543655	0	SF-1	7,11	NR5A1	0,5	SF-1	NR5A1	7536	2516	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	NR5A1 -LRB- SF-1 -RRB- mutations are not a major cause of primary ovarian_insufficiency .
23313103	0	SF-1	45,49	POD-1	0,5	SF-1	POD-1	7536	6943	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	POD-1 binding to the E-box sequence inhibits SF-1 and StAR expression in human adrenocortical_tumor cells .
26421867	0	SF-1	46,50	POD-1	0,5	SF-1	POD-1	117855(Tax:10116)	252856(Tax:10116)	Gene	Gene	reduces|dobj|START_ENTITY END_ENTITY|appos|reduces	POD-1 / Tcf21 overexpression reduces endogenous SF-1 and StAR expression in rat adrenal cells .
20133449	0	SF-1	96,100	PPAR-gamma_coactivator-1alpha	0,29	SF-1	PPAR-gamma coactivator-1alpha	117855(Tax:10116)	83516(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PPAR-gamma_coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1 .
15129808	0	SF-1	77,81	Sp1	112,115	SF-1	Sp1	7536	6667	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Characterization of binding between SF-1 and Sp1 : predominant interaction of SF-1 with the N-terminal region of Sp1 .
21242195	0	SF1	42,45	NR5A1	47,52	SF1	NR5A1	7536	2516	Gene	Gene	changes|compound|START_ENTITY changes|appos|END_ENTITY	Identification of novel SRY mutations and SF1 -LRB- NR5A1 -RRB- changes in patients with pure gonadal_dysgenesis and 46 , XY karyotype .
21654157	0	SF1	31,34	NR5A1	24,29	SF1	NR5A1	7536	2516	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Partial deletion of the NR5A1 -LRB- SF1 -RRB- gene detected by synthetic probe MLPA in a patient with XY_gonadal_disorder of sex development .
12732652	0	SF1	76,79	SOX8	0,4	SF1	SOX8	22668(Tax:10090)	20681(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro .
10092085	0	SF2	0,3	CD45	28,32	SF2	CD45	6426	5788	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation .
11046128	0	SF2/ASF	102,109	U1_snRNP	50,58	SF2/ASF	U1 snRNP	6426	26871;55599	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	Selection of alternative 5 ' splice sites : role of U1_snRNP and models for the antagonistic effects of SF2/ASF and hnRNP_A1 .
22489043	0	SF3B1	69,74	CBL	28,31	SF3B1	CBL	23451	867	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	SF3B1	69,74	DNMT3A	33,39	SF3B1	DNMT3A	23451	1788	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	SF3B1	69,74	IDH1	41,45	SF3B1	IDH1	23451	3417	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
26562302	0	SF3B1	47,52	IDH1	28,32	SF3B1	IDH1	23451	3417	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
22489043	0	SF3B1	69,74	IDH2	47,51	SF3B1	IDH2	23451	3418	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
26562302	0	SF3B1	47,52	IDH2	34,38	SF3B1	IDH2	23451	3418	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
22489043	0	SF3B1	69,74	JAK2	53,57	SF3B1	JAK2	23451	3717	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	SF3B1	69,74	MPL	59,62	SF3B1	MPL	23451	4352	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
22489043	0	SF3B1	69,74	NF1	64,67	SF3B1	NF1	23451	4763	Gene	Gene	SUZ12|appos|START_ENTITY SUZ12|appos|END_ENTITY	Mutation analysis of ASXL1 , CBL , DNMT3A , IDH1 , IDH2 , JAK2 , MPL , NF1 , SF3B1 , SUZ12 , and TET2 in myeloproliferative neoplasms .
26508027	0	SF3B1	45,50	SRSF2	52,57	SF3B1	SRSF2	23451	6427	Gene	Gene	ASXL1|nummod|START_ENTITY ASXL1|nummod|END_ENTITY	Genetic landscape of recurrent ASXL1 , U2AF1 , SF3B1 , SRSF2 , and EZH2 mutations in 304 Chinese patients with myelodysplastic_syndromes .
26562302	0	SF3B1	47,52	SRSF2	40,45	SF3B1	SRSF2	23451	6427	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
26508027	0	SF3B1	45,50	U2AF1	38,43	SF3B1	U2AF1	23451	7307	Gene	Gene	ASXL1|nummod|START_ENTITY ASXL1|nummod|END_ENTITY	Genetic landscape of recurrent ASXL1 , U2AF1 , SF3B1 , SRSF2 , and EZH2 mutations in 304 Chinese patients with myelodysplastic_syndromes .
18713018	0	SF3a3	117,122	CAR	89,92	SF3a3	CAR	10946	9970	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Specific inhibition of transcriptional activity of the constitutive_androstane_receptor -LRB- CAR -RRB- by the splicing factor SF3a3 .
9294006	0	SFA-1	55,60	PETA-3	61,67	SFA-1	PETA-3	12476(Tax:10090)	12476(Tax:10090)	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Molecular cloning and expression of mouse homologue of SFA-1 / PETA-3 -LRB- CD151 -RRB- , a member of the transmembrane 4 superfamily .
23592795	0	SFMBT1	0,6	LSD1	22,26	SFMBT1	LSD1	51460	23028	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors .
25998385	0	SFPQ	82,86	NONO	88,92	SFPQ	NONO	654780	4841	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Characterization of DNA binding and pairing activities associated with the native SFPQ __ NONO DNA repair protein complex .
11222670	0	SFRP-2	30,36	Pax-6	0,5	SFRP-2	Pax-6	20319(Tax:10090)	18508(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS .
16567562	0	SFRP1	45,50	secreted_frizzled-related_protein_1	8,43	SFRP1	secreted frizzled-related protein 1	20377(Tax:10090)	20377(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of secreted_frizzled-related_protein_1 -LRB- SFRP1 -RRB- in wound healing .
16410723	0	SFRP1	63,68	secreted_frizzled_related_protein_1	26,61	SFRP1	secreted frizzled related protein 1	6422	6422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epigenetic suppression of secreted_frizzled_related_protein_1 -LRB- SFRP1 -RRB- expression in human breast_cancer .
17848950	0	SFRP2	73,78	secreted_frizzled-related_protein_2	36,71	SFRP2	secreted frizzled-related protein 2	6423	6423	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Frequent epigenetic inactivation of secreted_frizzled-related_protein_2 -LRB- SFRP2 -RRB- by promoter methylation in human gastric_cancer .
14561758	0	SFRP2	41,46	secreted_frizzled_related_protein_2	4,39	SFRP2	secreted frizzled related protein 2	6423	6423	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The secreted_frizzled_related_protein_2 -LRB- SFRP2 -RRB- gene is a target of the Pax2 transcription factor .
23326605	0	SFRP4	19,24	EMT	35,38	SFRP4	EMT	6424	3702	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The Wnt gatekeeper SFRP4 modulates EMT , cell migration and downstream Wnt signalling in serous ovarian_cancer cells .
23908081	0	SFRP4	36,41	Wnt	56,59	SFRP4	Wnt	89803(Tax:10116)	114487(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Chuju total flavonoids control the SFRP4 expression in Wnt pathway in rheumatoid_arthritis model rats -RSB- .
19480240	0	SFRP4	51,56	secreted_frizzled-related_protein_4	14,49	SFRP4	secreted frizzled-related protein 4	6424	6424	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of secreted_frizzled-related_protein_4 -LRB- SFRP4 -RRB- in primary_serous_ovarian_tumours .
25408147	0	SFRP4	52,57	secreted_frizzled-related_protein_4	15,50	SFRP4	secreted frizzled-related protein 4	6424	6424	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of secreted_frizzled-related_protein_4 -LRB- SFRP4 -RRB- with type 2 diabetes in patients with stable coronary_artery_disease .
18356147	0	SFRP5	68,73	secreted_frizzled-related_protein-5	31,66	SFRP5	secreted frizzled-related protein-5	6425	6425	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic inactivation of the secreted_frizzled-related_protein-5 -LRB- SFRP5 -RRB- gene in human breast_cancer is associated with unfavorable prognosis .
21707890	1	SFTPC	242,247	surfactant_protein_C	220,240	hSP-C	surfactant protein C	6440	6440	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interstitial_lung_disease in both children and adults has been linked to mutations in the lung-specific surfactant_protein_C -LRB- SFTPC -RRB- gene .
24347240	0	SFTPC	60,65	surfactant_protein_C	38,58	SFTPC	surfactant protein C	6440	6440	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Survival of an infant with homozygous surfactant_protein_C -LRB- SFTPC -RRB- mutation .
15700120	0	SFTPD	49,54	surfactant_protein-D	27,47	SFTPD	surfactant protein-D	6441	6441	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the human surfactant_protein-D -LRB- SFTPD -RRB- gene : strong evidence that serum levels of surfactant_protein-D -LRB- SP-D -RRB- are genetically influenced .
18785967	0	SFTPD	64,69	surfactant_protein-D	42,62	SFTPD	surfactant protein-D	6441	6441	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of polymorphisms in the human surfactant_protein-D -LRB- SFTPD -RRB- gene and postnatal pulmonary adaptation in the preterm infant .
12039050	0	SFXN5	26,31	sideroflexin_5	10,24	SFXN5	sideroflexin 5	94097	94097	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human sideroflexin_5 -LRB- SFXN5 -RRB- gene : sequence , expression analysis and exclusion as a candidate for PARK3 .
25035075	0	SG2NA	0,5	DJ-1	15,19	SG2NA	DJ-1	6801	11315	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to protect cells from oxidative damage .
24399467	0	SGEF	20,24	Grb2	0,4	SGEF	Grb2	26084	2885	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Grb2 interacts with SGEF and antagonizes the ability of SGEF to enhance EGF-induced ERK1/2 activation .
23070540	0	SGF-3	137,142	sericin-1	73,82	SGF-3	sericin-1	693025(Tax:7091)	693057(Tax:7091)	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Inhibition of the binding of MSG-intermolt-specific complex , MIC , to the sericin-1 gene promoter and sericin-1 gene expression by POU-M1 / SGF-3 .
10825204	0	SGK	53,56	Sli2	0,4	SGK	Sli2	6446	171014	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Sli2 -LRB- Ypk1 -RRB- , a homologue of mammalian protein kinase SGK , is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast .
15576372	0	SGK	75,78	serum_and_glucocorticoid-regulated_kinase	32,73	SGK	serum and glucocorticoid-regulated kinase	6446	6446	Gene	Gene	ubiquitination|appos|START_ENTITY ubiquitination|amod|END_ENTITY	Nedd4-2 phosphorylation induces serum_and_glucocorticoid-regulated_kinase -LRB- SGK -RRB- ubiquitination and degradation .
18713960	0	SGK-1	43,48	Corticotropin-releasing_hormone	0,31	SGK-1	Corticotropin-releasing hormone	6446	1392	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1 .
15845389	0	SGK1	29,33	ASCT2	82,87	SGK1	ASCT2	6446	6510	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	The serine/threonine kinases SGK1 , 3 and PKB stimulate the amino_acid transporter ASCT2 .
15843443	0	SGK1	8,12	ENaC	43,47	SGK1	ENaC	20393(Tax:10090)	20276(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Role of SGK1 in nitric_oxide inhibition of ENaC in Na + - transporting epithelia .
24864229	0	SGK1	98,102	FOXO3A	156,162	SGK1	FOXO3A	6446	2309	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Diverse effects of ANXA7 and p53 on LNCaP prostate_cancer cells are associated with regulation of SGK1 transcription and phosphorylation of the SGK1 target FOXO3A .
19088452	0	SGK1	64,68	PEPT2	24,29	SGK1	PEPT2	399130(Tax:8355)	380090(Tax:8355)	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	The peptide transporter PEPT2 is targeted by the protein kinase SGK1 and the scaffold protein NHERF2 .
21413931	0	SGK1	65,69	Protor-1	0,8	SGK1	Protor-1	20393(Tax:10090)	109270(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney .
16006511	0	SGK1	15,19	WNK1	0,4	SGK1	WNK1	6446	65125	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	WNK1 activates SGK1 to regulate the epithelial sodium channel .
16081417	0	SGK1	15,19	WNK1	0,4	SGK1	WNK1	6446	65125	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism .
17360471	0	SGK1	3,7	WNK4	16,20	SGK1	WNK4	6446	65266	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	An SGK1 site in WNK4 regulates Na + channel and K + channel activity and has implications for aldosterone signaling and K + homeostasis .
25458846	0	SGK3	0,4	PI3K	31,35	SGK3	PI3K	23678	5290	Gene	Gene	Mediates|compound|START_ENTITY INPP4B-Dependent|nsubj|Mediates INPP4B-Dependent|dobj|Signaling Signaling|compound|END_ENTITY	SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast_Cancer .
25583802	0	SGK3	56,60	PI3K	0,4	SGK3	PI3K	23678	5293	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	PI3K Transduces AKT-Independent Oncogenic Signaling via SGK3 and INPP4B .
26209767	0	SGLT-2	97,103	sodium-glucose_co-transporter_2	64,95	SGLT-2	sodium-glucose co-transporter 2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A quantitative LC-MS/MS method for determining ipragliflozin , a sodium-glucose_co-transporter_2 -LRB- SGLT-2 -RRB- inhibitor , and its application to a pharmacokinetic study in rats .
26989857	0	SGLT-2	103,109	sodium-glucose_co-transporter_2	70,101	SGLT-2	sodium-glucose co-transporter 2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A validated LC-MS/MS method for the determination of canagliflozin , a sodium-glucose_co-transporter_2 -LRB- SGLT-2 -RRB- inhibitor , in a lower volume of rat plasma : application to pharmacokinetic studies in rats .
24829965	0	SGLT-2	91,97	sodium-glucose_cotransporter_2	59,89	SGLT-2	sodium-glucose cotransporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	The safety of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors or sodium-glucose_cotransporter_2 -LRB- SGLT-2 -RRB- inhibitors added to metformin background therapy in patients with type_2_diabetes_mellitus : a systematic review and meta-analysis .
23602371	0	SGLT1	41,46	EGFR	0,4	SGLT1	EGFR	6523	1956	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	EGFR cooperates with glucose transporter SGLT1 to enable chromatin remodeling in response to ionizing radiation .
23765757	0	SGLT1	78,83	EGFR	120,124	SGLT1	EGFR	6523	1956	Gene	Gene	inhibition|nmod|START_ENTITY sensitizes|nsubj|inhibition sensitizes|nmod|inhibitors inhibitors|amod|END_ENTITY	EGFR-SGLT1 interaction does not respond to EGFR modulators , but inhibition of SGLT1 sensitizes prostate_cancer cells to EGFR tyrosine kinase inhibitors .
23008432	0	SGLT1	52,57	LeuT	75,79	SGLT1	LeuT	6523	3343	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Simulated annealing reveals the kinetic activity of SGLT1 , a member of the LeuT structural family .
20060848	0	SGLT1	55,60	Sp1	34,37	SGLT1	Sp1	20537(Tax:10090)	20683(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
20069550	0	SGLT1	133,138	sodium-dependent_glucose_co-transporter	93,132	SGLT1	sodium-dependent glucose co-transporter	100008981(Tax:9986)	100008981(Tax:9986)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Protein kinase C mediated intracellular signaling pathways are involved in the regulation of sodium-dependent_glucose_co-transporter SGLT1 activity .
9109390	0	SGLT1	82,87	sodium-glucose-linked_transporter	47,80	SGLT1	sodium-glucose-linked transporter	25552(Tax:10116)	25552(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transcriptional and translational control over sodium-glucose-linked_transporter -LRB- SGLT1 -RRB- gene expression in adult rat small intestine .
7675626	0	SGLT1	70,75	sodium-glucose_transporter	42,68	SGLT1	sodium-glucose transporter	25552(Tax:10116)	25552(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The effects of streptozotocin diabetes on sodium-glucose_transporter -LRB- SGLT1 -RRB- expression and function in rat jejunal and ileal villus-attached enterocytes .
27053360	0	SGLT2	84,89	PPAR	56,60	SGLT2	PPAR	246787(Tax:10090)	19013(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Sodium Intake Regulates Glucose Homeostasis through the PPAR / Adiponectin-Mediated SGLT2 Pathway .
26185406	0	SGLT2	37,42	Sodium-Glucose_Linked_Transporter_2	0,35	SGLT2	Sodium-Glucose Linked Transporter 2	6524	6524	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Sodium-Glucose_Linked_Transporter_2 -LRB- SGLT2 -RRB- Inhibitors in the Management Of Type-2 Diabetes : A Drug Class Overview .
24972995	0	SGLT2	37,42	Sodium-Glucose_linked_transporter_2	0,35	SGLT2	Sodium-Glucose linked transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Sodium-Glucose_linked_transporter_2 -LRB- SGLT2 -RRB- inhibitors -- fighting diabetes from a new perspective .
25598831	0	SGLT2	33,38	Sodium-glucose_co-transporter_2	0,31	SGLT2	Sodium-glucose co-transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Sodium-glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors : a growing class of antidiabetic agents .
22583331	0	SGLT2	33,38	Sodium_glucose_co-transporter_2	0,31	SGLT2	Sodium glucose co-transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Sodium_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors : novel antidiabetic agents .
19700318	0	SGLT2	78,83	sodium-dependent_glucose_co-transporter_2	35,76	SGLT2	sodium-dependent glucose co-transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	O-Spiro_C-aryl_glucosides as novel sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
19896374	0	SGLT2	117,122	sodium-dependent_glucose_co-transporter_2	74,115	SGLT2	sodium-dependent glucose co-transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Exploration of O-spiroketal_C-arylglucosides as novel and selective renal sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
20576578	0	SGLT2	116,121	sodium-dependent_glucose_co-transporter_2	73,114	SGLT2	sodium-dependent glucose co-transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	ortho-Substituted_C-aryl_glucosides as highly potent and selective renal sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
21090651	0	SGLT2	70,75	sodium-dependent_glucose_co-transporter_2	27,68	SGLT2	sodium-dependent glucose co-transporter 2	6524	6524	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of non-glycoside sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors by ligand-based virtual screening .
21737266	0	SGLT2	122,127	sodium-dependent_glucose_co-transporter_2	79,120	SGLT2	sodium-dependent glucose co-transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	C-aryl_glucosides substituted at the 4 ' - position as potent and selective renal sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors for the treatment of type 2 diabetes .
22120948	0	SGLT2	77,82	sodium-dependent_glucose_co-transporter_2	34,75	SGLT2	sodium-dependent glucose co-transporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	A specific pharmacophore model of sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
18260618	0	SGLT2	96,101	sodium-dependent_glucose_cotransporter_2	54,94	SGLT2	sodium-dependent glucose cotransporter 2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Discovery of dapagliflozin : a potent , selective renal sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
19785435	0	SGLT2	82,87	sodium-dependent_glucose_cotransporter_2	40,80	SGLT2	sodium-dependent glucose cotransporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Novel L-xylose derivatives as selective sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitors for the treatment of type 2 diabetes .
20180760	0	SGLT2	48,53	sodium-dependent_glucose_cotransporter_2	6,46	SGLT2	sodium-dependent glucose cotransporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Renal sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitors for new anti-diabetic agent .
21873071	0	SGLT2	90,95	sodium-dependent_glucose_cotransporter_2	48,88	SGLT2	sodium-dependent glucose cotransporter 2	246787(Tax:10090)	246787(Tax:10090)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	5a-Carba-b-D-glucopyranose derivatives as novel sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitors for the treatment of type 2 diabetes .
24991224	0	SGLT2	54,59	sodium-glucose_co-transporter_2	21,52	SGLT2	sodium-glucose co-transporter 2	6524	6524	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Empagliflozin : a new sodium-glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
22429686	0	SGLT2	61,66	sodium-glucose_cotransporter	31,59	SGLT2	sodium-glucose cotransporter	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ursodeoxycholic_acid decreases sodium-glucose_cotransporter -LRB- SGLT2 -RRB- expression and oxidative stress in the kidney of diabetic rats .
23563279	0	SGLT2	56,61	sodium-glucose_cotransporter-2	24,54	SGLT2	sodium-glucose cotransporter-2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Ipragliflozin and other sodium-glucose_cotransporter-2 -LRB- SGLT2 -RRB- inhibitors in the treatment of type 2 diabetes : preclinical and clinical data .
21410690	0	SGLT2	78,83	sodium-glucose_cotransporter_2	46,76	SGLT2	sodium-glucose cotransporter 2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	TS-071 is a novel , potent and selective renal sodium-glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor with anti-hyperglycaemic activity .
24420910	0	SGLT2	66,71	sodium-glucose_cotransporters_type_2	28,64	SGLT2	sodium-glucose cotransporters type 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Drug-drug interactions with sodium-glucose_cotransporters_type_2 -LRB- SGLT2 -RRB- inhibitors , new oral glucose-lowering agents for the management of type_2_diabetes_mellitus .
16380256	0	SGLT2	60,65	sodium_glucose_co-transporter_2	27,58	SGLT2	sodium glucose co-transporter 2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Indole-glucosides as novel sodium_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
23253948	0	SGLT2	69,74	sodium_glucose_cotransporter-2	37,67	SGLT2	sodium glucose cotransporter-2	6524	6524	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacokinetics of empagliflozin , a sodium_glucose_cotransporter-2 -LRB- SGLT2 -RRB- inhibitor , and metformin following co-administration in healthy volunteers .
24964723	0	SGLT2	81,86	sodium_glucose_cotransporter_2	49,79	SGLT2	sodium glucose cotransporter 2	6524	6524	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Exposure-response modelling for empagliflozin , a sodium_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor , in patients with type 2 diabetes .
21606218	0	SGLT_2	40,46	sodium-glucose_cotransporter_2	8,38	SGLT 2	sodium-glucose cotransporter 2	6524	6524	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Role of sodium-glucose_cotransporter_2 -LRB- SGLT_2 -RRB- inhibitors in the treatment of type 2 diabetes .
25831888	0	SGMS1	41,46	sphingomyelin_synthase_1	15,39	SGMS1	sphingomyelin synthase 1	259230	259230	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Expression of sphingomyelin_synthase_1 -LRB- SGMS1 -RRB- gene varies in human lung and oesophagus_cancer -RSB- .
10588842	0	SGN3	52,56	COP9	21,25	SGN3	COP9	8533	10920	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hemizygosity for the COP9 signalosome subunit gene , SGN3 , in the Smith-Magenis_syndrome .
8848570	0	SGP-1	25,30	Sulfated_glycoprotein-1	0,23	SGP-1	Sulfated glycoprotein-1	25524(Tax:10116)	25524(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sulfated_glycoprotein-1 -LRB- SGP-1 -RRB- expression in ovine endometrium during the oestrous cycle and early pregnancy .
12965054	0	SGP-1	123,128	prosaposin	111,121	SGP-1	prosaposin	25524(Tax:10116)	25524(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Regulation of gene expression in response to brain_injury : enhanced expression and alternative splicing of rat prosaposin -LRB- SGP-1 -RRB- mRNA in injured brain .
9266755	0	SGP-1	45,50	prosaposin	33,43	SGP-1	prosaposin	109941(Tax:10090)	19156(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structural analysis of the mouse prosaposin -LRB- SGP-1 -RRB- gene reveals the presence of an exon that is alternatively spliced in transcribed mRNAs .
7702875	0	SGP-1	33,38	sulfated_glycoprotein-1	8,31	SGP-1	sulfated glycoprotein-1	25524(Tax:10116)	25524(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of sulfated_glycoprotein-1 -LRB- SGP-1 -RRB- in the disposal of residual bodies by Sertoli cells of the rat .
14618611	0	SGP-2	11,16	Clusterin	0,9	SGP-2	Clusterin	1191	1191	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clusterin -LRB- SGP-2 , ApoJ -RRB- expression is downregulated in low - and high-grade human prostate_cancer .
8963451	0	SGP-2	11,16	Clusterin	0,9	SGP-2	Clusterin	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Clusterin -LRB- SGP-2 -RRB- induction in rat astroglial cells exposed to prion protein fragment 106-126 .
9815554	0	SGP-2	24,29	Clusterin	31,40	SGP-2	Clusterin	1191	1191	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Intracellular levels of SGP-2 -LRB- Clusterin -RRB- correlate with tumor grade in prostate_cancer .
1749509	0	SGP-2	25,30	Sulfated_glycoprotein-2	0,23	SGP-2	Sulfated glycoprotein-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Sulfated_glycoprotein-2 -LRB- SGP-2 -RRB- mRNA is expressed in rat striatal astrocytes following ibotenic_acid lesions .
1472369	0	SGP-2	40,45	TRPM-2	46,52	SGP-2	TRPM-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Developmental expression of the S35-S45 / SGP-2 / TRPM-2 gene in rat testis and epididymis .
11054633	0	SGP-2	31,36	clusterin	20,29	SGP-2	clusterin	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Increased levels of clusterin -LRB- SGP-2 -RRB- mRNA and protein accompany rat ventral prostate involution following finasteride treatment .
17558187	0	SGP-2	47,52	sulfated_glycoprotein-2	22,45	SGP-2	sulfated glycoprotein-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression pattern of sulfated_glycoprotein-2 -LRB- SGP-2 -RRB- mRNA in rat testes exposed to endocrine disruptors .
14643435	0	SGS1	20,24	DNA2	26,30	SGS1	DNA2	855228(Tax:4932)	856569(Tax:4932)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Evidence that yeast SGS1 , DNA2 , SRS2 , and FOB1 interact to maintain rDNA stability .
18407553	0	SGSH	51,55	sulphamidase	32,44	SGSH	sulphamidase	6448	6448	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The mutation p.Ser298Pro in the sulphamidase gene -LRB- SGSH -RRB- is associated with a slowly progressive clinical phenotype in mucopolysaccharidosis_type_IIIA -LRB- Sanfilippo_A_syndrome -RRB- .
16777091	0	SGT	6,9	Scythe	37,43	SGT	Scythe	6449	7917	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human SGT interacts with Bag-6 / Bat-3 / Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic_arrest .
24050553	0	SGT	90,93	Small_glutamine-rich_tetratricopeptide_repeat-containing_protein	24,88	SGT	Small glutamine-rich tetratricopeptide repeat-containing protein	6449	6449	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of Small_glutamine-rich_tetratricopeptide_repeat-containing_protein -LRB- SGT -RRB- correlated with prognosis of Hepatocellular_carcinoma .
24195513	0	SGT	90,93	Small_glutamine-rich_tetratricopeptide_repeat-containing_protein	24,88	SGT	Small glutamine-rich tetratricopeptide repeat-containing protein	6449	6449	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of Small_glutamine-rich_tetratricopeptide_repeat-containing_protein -LRB- SGT -RRB- correlated with prognosis of Hepatocellular_carcinoma .
23440515	0	SGT1	0,4	Akt	15,18	SGT1	Akt	10910	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric_cancer cells .
17441508	0	SGT2	0,4	YDJ1	48,52	SGT2	YDJ1	854168(Tax:4932)	855661(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces_cerevisiae .
26645561	0	SH-1242	16,23	Hsp90	33,38	SH-1242	Hsp90	3481743(Tax:279808)	3320	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Deguelin analog SH-1242 inhibits Hsp90 activity and exerts potent anticancer efficacy with limited neurotoxicity .
7889566	0	SH-PTP1	24,31	erythropoietin	39,53	SH-PTP1	erythropoietin	5777	2056	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals .
1570157	0	SH2	116,119	p56lck	88,94	SH2	p56lck	100125854(Tax:10090)	16818(Tax:10090)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains .
10594240	0	SH2-B	56,61	insulin_receptor	69,85	SH2-B	insulin receptor	20399(Tax:10090)	16337(Tax:10090)	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	Alternative splicing , gene localization , and binding of SH2-B to the insulin_receptor kinase domain .
15316008	0	SH2-B	0,5	insulin_receptor_substrate_1	15,43	SH2-B	insulin receptor substrate 1	25970	3667	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activation activation|amod|END_ENTITY	SH2-B promotes insulin_receptor_substrate_1 -LRB- IRS1 -RRB- - and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin .
10772872	0	SH2-Containing_protein_tyrosine_phosphatase-1	0,45	Jak2	71,75	SH2-Containing protein tyrosine phosphatase-1	Jak2	5777	3717	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	SH2-Containing_protein_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- association with Jak2 in UT-7 / Epo cells .
10772872	0	SH2-Containing_protein_tyrosine_phosphatase-1	0,45	SHP-1	47,52	SH2-Containing protein tyrosine phosphatase-1	SHP-1	5777	5777	Gene	Gene	association|amod|START_ENTITY association|appos|END_ENTITY	SH2-Containing_protein_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- association with Jak2 in UT-7 / Epo cells .
11313386	0	SH2-containing_inositol_phosphatase	34,69	CD150	0,5	SH2-containing inositol phosphatase	CD150	3635	6504	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	CD150 association with either the SH2-containing_inositol_phosphatase or the SH2-containing_protein_tyrosine_phosphatase is regulated by the adaptor protein SH2D1A .
26508024	0	SH2-containing_protein_tyrosine_phosphatase_1	54,99	SHP1	101,105	SH2-containing protein tyrosine phosphatase 1	SHP1	5777	5777	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Epigenetic regulation and anti-tumorigenic effects of SH2-containing_protein_tyrosine_phosphatase_1 -LRB- SHP1 -RRB- in human gastric_cancer cells .
9207119	0	SH2-domain-containing_leukocyte_protein_76	57,99	interleukin_2	114,127	SH2-domain-containing leukocyte protein 76	interleukin 2	3937	3558	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing_leukocyte_protein_76 and modulates interleukin_2 production .
18061583	0	SH2-domain_containing_inositol_phosphatase_2	14,58	SHIP2	60,65	SH2-domain containing inositol phosphatase 2	SHIP2	65038(Tax:10116)	65038(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of SH2-domain_containing_inositol_phosphatase_2 -LRB- SHIP2 -RRB- in insulin producing INS1E cells improves insulin signal transduction and induces proliferation .
20333234	0	SH2B	75,79	Lnk	89,92	SH2B	Lnk	43130(Tax:7227)	43130(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Regulation of lifespan , metabolism , and stress responses by the Drosophila SH2B protein , Lnk .
17204555	0	SH2B1	48,53	Janus_kinase-2	79,93	SH2B1	Janus kinase-2	25970	3717	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Identification of SH2B2beta as an inhibitor for SH2B1 - and SH2B2alpha-promoted Janus_kinase-2 activation and insulin signaling .
24645678	0	SH2B1	0,5	insulin	26,33	SH2B1	insulin	20399(Tax:10090)	3630	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	SH2B1 in b-cells promotes insulin expression and glucose metabolism in mice .
17565041	0	SH2B1	0,5	leptin	15,21	SH2B1	leptin	25970	3952	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	SH2B1 enhances leptin signaling by both Janus_kinase_2 Tyr813 phosphorylation-dependent and - independent mechanisms .
23590807	0	SH2B3	0,5	LNK	7,10	SH2B3	LNK	10019	10019	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	SH2B3 -LRB- LNK -RRB- mutations from myeloproliferative_neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F .
21496118	0	SH2B3	34,39	Lnk	29,32	SH2B3	Lnk	10019	10019	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|END_ENTITY	Gene transfer of the adaptor Lnk -LRB- SH2B3 -RRB- prevents porcine endothelial cell activation and apoptosis : implication for xenograft 's cytoprotection .
10752626	0	SH2D2A	4,10	T-cell-specific_adapter_protein	29,60	SH2D2A	T-cell-specific adapter protein	9047	9047	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	The SH2D2A gene encoding the T-cell-specific_adapter_protein -LRB- TSAd -RRB- is localized centromeric to the CD1 gene cluster on human Chromosome 1 .
14502564	0	SH2_domain-containing_inositol_5-phosphatase	25,69	SHIP2	71,76	SH2 domain-containing inositol 5-phosphatase	SHIP2	3636	3636	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of endogenous SH2_domain-containing_inositol_5-phosphatase -LRB- SHIP2 -RRB- in 3T3-L1 and human preadipocytes .
26456051	0	SH2_domain-containing_inositol_5-phosphatase	0,44	SHIP2	46,51	SH2 domain-containing inositol 5-phosphatase	SHIP2	3636	3636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	SH2_domain-containing_inositol_5-phosphatase -LRB- SHIP2 -RRB- inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells .
19880507	0	SH2_domain-containing_inositol_phosphatase_2	7,51	SHIP2	0,5	SH2 domain-containing inositol phosphatase 2	SHIP2	3636	3636	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	SHIP2 -LRB- SH2_domain-containing_inositol_phosphatase_2 -RRB- SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor .
23946508	0	SH2_domain-containing_phosphatase-2	66,101	Heterogeneous_nuclear_ribonucleoprotein_Q	0,41	SH2 domain-containing phosphatase-2	Heterogeneous nuclear ribonucleoprotein Q	5781	10492	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_Q is a novel substrate of SH2_domain-containing_phosphatase-2 .
7947763	0	SH3	75,78	Grb2	89,93	SH3	Grb2	100125849(Tax:10090)	14784(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy .
7534229	0	SH3	31,34	Src	27,30	Src	Src	20779(Tax:10090)	20779(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Mutational analysis of the Src SH3 domain : the same residues of the ligand binding surface are important for intra - and intermolecular interactions .
24046450	0	SH3	12,15	nebulin	4,11	SH3	nebulin	100125849(Tax:10090)	17996(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse .
21658605	0	SH3BP1	0,6	Rac1	50,54	SH3BP1	Rac1	23616	5879	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	SH3BP1 , an exocyst-associated RhoGAP , inactivates Rac1 at the front to drive cell motility .
9809064	0	SH3GL3	0,6	Huntingtin	27,37	SH3GL3	Huntingtin	6457	3064	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates .
19837132	0	SH3MD1	60,66	SH3PXD2A	50,58	SH3MD1	SH3PXD2A	9644	9644	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	A study of the association between the ADAM12 and SH3PXD2A -LRB- SH3MD1 -RRB- genes and Alzheimer 's _ disease .
19837132	0	SH3PXD2A	50,58	SH3MD1	60,66	SH3PXD2A	SH3MD1	9644	9644	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	A study of the association between the ADAM12 and SH3PXD2A -LRB- SH3MD1 -RRB- genes and Alzheimer 's _ disease .
21709223	0	SHANK-associated_RH_domain-interacting_protein	50,96	Toll-like_receptor_2	121,141	SHANK-associated RH domain-interacting protein	Toll-like receptor 2	106025(Tax:10090)	24088(Tax:10090)	Gene	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	Systems analysis identifies an essential role for SHANK-associated_RH_domain-interacting_protein -LRB- SHARPIN -RRB- in macrophage Toll-like_receptor_2 -LRB- TLR2 -RRB- responses .
16129689	0	SHARP	86,91	EB2	57,60	SHARP	EB2	23013	10982	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of the Epstein-Barr_virus mRNA export factor EB2 with human Spen proteins SHARP , OTT1 , and a novel member of the family , OTT3 , links Spen proteins with splicing regulation and mRNA export .
23096663	0	SHBG	31,35	Sex-hormone_binding_globulin	1,29	SHBG	Sex-hormone binding globulin	6462	6462	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	-LSB- Sex-hormone_binding_globulin -LRB- SHBG -RRB- levels during pregnancy as predictors for pre-eclampsia and fetal growth restriction -RSB- .
24327369	0	SHBG	79,83	Sex_Hormone-Binding_Globulin	49,77	SHBG	Sex Hormone-Binding Globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single-nucleotide polymorphism , rs1799941 in the Sex_Hormone-Binding_Globulin -LRB- SHBG -RRB- gene , related to both serum testosterone and SHBG levels and the risk of myocardial_infarction , type 2 diabetes , cancer and mortality in men : the Troms Study .
26600064	0	SHBG	53,57	Sex_Hormone-Binding_Globulin	23,51	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Common Variants in the Sex_Hormone-Binding_Globulin -LRB- SHBG -RRB- Gene Influence SHBG Levels in Women with Polycystic_Ovary_Syndrome .
25226295	0	SHBG	30,34	Sex_hormone-binding_globulin	0,28	SHBG	Sex hormone-binding globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sex_hormone-binding_globulin -LRB- SHBG -RRB- gene expression and insulin resistance .
1483288	0	SHBG	77,81	sex-hormone-binding_globulin	47,75	SHBG	sex-hormone-binding globulin	6462	6462	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Subtle changes in serum thyrotrophin -LRB- TSH -RRB- and sex-hormone-binding_globulin -LRB- SHBG -RRB- levels during long-term follow-up after radioactive_iodine in multinodular non-toxic goitre .
14671199	0	SHBG	85,89	sex_hormone-binding_globulin	55,83	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the -LRB- TAAAA -RRB- n repeat polymorphism in the sex_hormone-binding_globulin -LRB- SHBG -RRB- gene with polycystic_ovary_syndrome and relation to SHBG serum levels .
15149727	0	SHBG	44,48	sex_hormone-binding_globulin	14,42	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of sex_hormone-binding_globulin -LRB- SHBG -RRB- in human granulosa-lutein cells .
15807883	0	SHBG	46,50	sex_hormone-binding_globulin	16,44	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of sex_hormone-binding_globulin -LRB- SHBG -RRB- are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men .
16028066	0	SHBG	52,56	sex_hormone-binding_globulin	22,50	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of sex_hormone-binding_globulin -LRB- SHBG -RRB- in human ovarian follicles and corpus luteum .
19679209	0	SHBG	62,66	sex_hormone-binding_globulin	32,60	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of polymorphisms of the sex_hormone-binding_globulin -LRB- SHBG -RRB- gene on free estradiol and bone_mineral_density .
20974254	0	SHBG	100,104	sex_hormone-binding_globulin	70,98	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the -LRB- TAAAA -RRB- n repeat and Asp327Asn polymorphisms in the sex_hormone-binding_globulin -LRB- SHBG -RRB- gene with idiopathic_male_infertility and relation to serum SHBG concentrations .
2106280	0	SHBG	40,44	sex_hormone-binding_globulin	10,38	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	Assay|appos|START_ENTITY Assay|nmod|END_ENTITY	-LSB- Assay of sex_hormone-binding_globulin -LRB- SHBG -RRB- in human serum .
23001781	0	SHBG	58,62	sex_hormone-binding_globulin	23,51	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common variants in the sex_hormone-binding_globulin gene -LRB- SHBG -RRB- and polycystic_ovary_syndrome -LRB- PCOS -RRB- in Mediterranean women .
7505768	0	SHBG	105,109	sex_hormone-binding_globulin	75,103	SHBG	sex hormone-binding globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of a MspI restriction fragment length polymorphism for the human sex_hormone-binding_globulin -LRB- SHBG -RRB- gene .
1637726	0	SHBG	45,49	sex_hormone_binding_globulin	15,43	SHBG	sex hormone binding globulin	6462	6462	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of sex_hormone_binding_globulin -LRB- SHBG -RRB- on testosterone transport into the cerebrospinal fluid .
18056923	0	SHBG	52,56	sex_hormone_binding_globulin	22,50	SHBG	sex hormone binding globulin	6462	6462	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Associations of serum sex_hormone_binding_globulin -LRB- SHBG -RRB- levels with SHBG gene polymorphisms in the CARDIA Male Hormone Study .
1958578	0	SHBG	41,45	sex_hormone_binding_globulin	11,39	SHBG	sex hormone binding globulin	6462	6462	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of sex_hormone_binding_globulin -LRB- SHBG -RRB- on human prostatic_carcinoma .
19933169	0	SHBG	59,63	sex_hormone_binding_globulin	29,57	SHBG	sex hormone binding globulin	6462	6462	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Genetic evidence that raised sex_hormone_binding_globulin -LRB- SHBG -RRB- levels reduce the risk of type 2 diabetes .
2391961	0	SHBG	54,58	sex_hormone_binding_globulin	24,52	SHBG	sex hormone binding globulin	6462	6462	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Direct effect of plasma sex_hormone_binding_globulin -LRB- SHBG -RRB- on the metabolic clearance rate of 17_beta-estradiol in the primate .
24456771	0	SHBG	46,50	sex_hormone_binding_globulin	16,44	SHBG	sex hormone binding globulin	6462	6462	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of sex_hormone_binding_globulin -LRB- SHBG -RRB- are not predictive of prostate_cancer diagnosis and aggressiveness : results from an Italian biopsy cohort .
15634719	0	SHBG	70,74	steroid_hormone-binding_globulin	36,68	SHBG	steroid hormone-binding globulin	6462	6462	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Common genetic variation in the sex steroid_hormone-binding_globulin -LRB- SHBG -RRB- gene and circulating shbg levels among postmenopausal women : the Multiethnic Cohort .
7681824	0	SHC	67,70	Epidermal_growth_factor	0,23	SHC	Epidermal growth factor	20416(Tax:10090)	13645(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHC in the mouse .
11997181	0	SHC	65,68	GRB2	86,90	SHC	GRB2	6464	2885	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2 .
7535773	0	SHC	51,54	Grb2	89,93	SHC	Grb2	6464	2885	Gene	Gene	proteins|compound|START_ENTITY phosphorylation|nmod|proteins phosphorylation|nmod|END_ENTITY	Growth_hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2 .
8868476	0	SHC	106,109	Src_homologous_and_collagen-like	72,104	SHC	Src homologous and collagen-like	6464	6464	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	pH-Dependent self-association of the Src homology 2 -LRB- SH2 -RRB- domain of the Src_homologous_and_collagen-like -LRB- SHC -RRB- protein .
9192859	0	SHC	26,29	p66	30,33	SHC	p66	6464	10714	Gene	Gene	START_ENTITY|dobj|cDNA cDNA|amod|END_ENTITY	Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13 .1 .
8645604	0	SHH	145,148	BMP-4	44,49	SHH	BMP-4	395615(Tax:9031)	396165(Tax:9031)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of bone_morphogenetic_protein-4 -LRB- BMP-4 -RRB- , bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- , fibroblast_growth_factor-8 -LRB- FGF-8 -RRB- and sonic_hedgehog -LRB- SHH -RRB- during branchial arch development in the chick .
24606742	0	SHH	100,103	Bcl-2	90,95	SHH	Bcl-2	6469	596	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Acyldepsipeptide 1 induces apoptosis in renal_cancer cells by down-regulation of Gli and Bcl-2 via SHH pathway -RSB- .
19561609	0	SHH	17,20	HHIP	37,41	SHH	HHIP	6469	64399	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling .
22683912	0	SHH	55,58	Sonic_Hedgehog	39,53	SHH	Sonic Hedgehog	6469	6469	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Duplication of 7q36 .3 encompassing the Sonic_Hedgehog -LRB- SHH -RRB- gene is associated with congenital_muscular_hypertrophy .
25750281	0	SHH	30,33	Sonic_Hedgehog	14,28	SHH	Sonic Hedgehog	6469	6469	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Sonic_Hedgehog -LRB- SHH -RRB- in Human Lung_Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung_Cancer Cells and Tumor Growth .
10441331	0	SHH	34,37	Sonic_hedgehog	18,32	SHH	Sonic hedgehog	6469	6469	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the Sonic_hedgehog -LRB- SHH -RRB- gene during early human development and phenotypic expression of new mutations causing holoprosencephaly .
25756958	0	SHH	44,47	sonic_hedgehog	28,42	SHH	sonic hedgehog	6469	6469	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Proteomic analysis of human sonic_hedgehog -LRB- SHH -RRB- medulloblastoma stem-like cells .
25756958	0	SHH	44,47	sonic_hedgehog	28,42	SHH	sonic hedgehog	6469	6469	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Proteomic analysis of human sonic_hedgehog -LRB- SHH -RRB- medulloblastoma stem-like cells .
10523635	0	SHIP	40,44	BCR/ABL	0,7	SHIP	BCR/ABL	16331(Tax:10090)	25	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	BCR/ABL directly inhibits expression of SHIP , an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis .
11971024	0	SHIP	0,4	IL-6	48,52	SHIP	IL-6	3635	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	SHIP negatively regulates IgE + antigen-induced IL-6 production in mast cells by inhibiting NF-kappa_B activity .
9110989	0	SHIP	68,72	Interleukin-3	0,13	SHIP	Interleukin-3	3635	3562	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2 .
21131429	0	SHIP	0,4	Th2	15,18	SHIP	Th2	16331(Tax:10090)	15111(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	SHIP represses Th2 skewing by inhibiting IL-4 production from basophils .
20445019	0	SHIP-1	25,31	Fli-1	59,64	SHIP-1	Fli-1	3635	2313	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis .
17307799	0	SHIP-1	57,63	KLRG1	0,5	SHIP-1	KLRG1	16331(Tax:10090)	50928(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	KLRG1 binds cadherins and preferentially associates with SHIP-1 .
17498626	0	SHIP-1	11,17	MMP2	21,25	SHIP-1	MMP2	16331(Tax:10090)	17390(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of SHIP-1 on MMP2 secretion and invasion of SR3Y1 cells .
15990278	0	SHIP1	91,96	KIT	159,162	SHIP1	KIT	16331(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mutants mutants|nmod|END_ENTITY	Differences in signaling pathways and expression level of the phosphoinositide phosphatase SHIP1 between two oncogenic mutants of the receptor_tyrosine_kinase KIT .
12791379	0	SHIP1	38,43	PI3K	19,23	SHIP1	PI3K	3635	5293	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases .
26304991	0	SHIP1	95,100	PSTPIP2	0,7	SHIP1	PSTPIP2	3635	9050	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	PSTPIP2 , a Protein Associated with Autoinflammatory_Disease , Interacts with Inhibitory Enzymes SHIP1 and Csk .
26304991	0	SHIP1	95,100	PSTPIP2	0,7	SHIP1	PSTPIP2	3635	9050	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	PSTPIP2 , a Protein Associated with Autoinflammatory_Disease , Interacts with Inhibitory Enzymes SHIP1 and Csk .
19359473	0	SHIP1	21,26	miR-155	50,57	SHIP1	miR-155	16331(Tax:10090)	387173(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Inositol phosphatase SHIP1 is a primary target of miR-155 .
25175984	0	SHIP1	0,5	miR-155	21,28	SHIP1	miR-155	3635	406947	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	SHIP1 is targeted by miR-155 in acute_myeloid_leukemia .
26447227	0	SHIP1	106,111	miR-155	0,7	SHIP1	miR-155	3635	406947	Gene	Gene	Sufficient|dep|START_ENTITY Is|xcomp|Sufficient Is|nsubj|Upregulation Upregulation|amod|END_ENTITY	miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1 .
25723258	0	SHIP1	21,26	p53	66,69	SHIP1	p53	3635	7157	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies .
17135240	0	SHIP2	44,49	EphA2	14,19	SHIP2	EphA2	3636	1969	Gene	Gene	phosphatase|compound|START_ENTITY endocytosis|nmod|phosphatase endocytosis|nsubj|Regulation Regulation|nmod|receptor receptor|amod|END_ENTITY	Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation .
22244754	0	SHIP2	134,139	EphA2	87,92	SHIP2	EphA2	3636	1969	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	NMR structure of a heterodimeric SAM : SAM complex : characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2 .
10610720	0	SHIP2	10,15	Inppl1	17,23	SHIP2	Inppl1	16332(Tax:10090)	16332(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse SHIP2 -LRB- Inppl1 -RRB- gene : complementary DNA , genomic structure , promoter analysis , and gene expression in the embryo and adult mouse .
18061583	0	SHIP2	60,65	SH2-domain_containing_inositol_phosphatase_2	14,58	SHIP2	SH2-domain containing inositol phosphatase 2	65038(Tax:10116)	65038(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of SH2-domain_containing_inositol_phosphatase_2 -LRB- SHIP2 -RRB- in insulin producing INS1E cells improves insulin signal transduction and induces proliferation .
14502564	0	SHIP2	71,76	SH2_domain-containing_inositol_5-phosphatase	25,69	SHIP2	SH2 domain-containing inositol 5-phosphatase	3636	3636	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of endogenous SH2_domain-containing_inositol_5-phosphatase -LRB- SHIP2 -RRB- in 3T3-L1 and human preadipocytes .
26456051	0	SHIP2	46,51	SH2_domain-containing_inositol_5-phosphatase	0,44	SHIP2	SH2 domain-containing inositol 5-phosphatase	3636	3636	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	SH2_domain-containing_inositol_5-phosphatase -LRB- SHIP2 -RRB- inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells .
19880507	0	SHIP2	0,5	SH2_domain-containing_inositol_phosphatase_2	7,51	SHIP2	SH2 domain-containing inositol phosphatase 2	3636	3636	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	SHIP2 -LRB- SH2_domain-containing_inositol_phosphatase_2 -RRB- SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor .
26553359	0	SHMT1	16,21	miR-198	0,7	SHMT1	miR-198	6470	406975	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung_adenocarcinoma .
25082541	0	SHON	0,4	transforming_growth_factor-b	84,112	SHON	transforming growth factor-b	3092	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	SHON , a novel secreted protein , regulates epithelial-mesenchymal transition through transforming_growth_factor-b signaling in human breast_cancer cells .
17566572	0	SHORT_VEGETATIVE_PHASE	20,42	SVP	44,47	SHORT VEGETATIVE PHASE	SVP	816787(Tax:3702)	816787(Tax:3702)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A conserved role of SHORT_VEGETATIVE_PHASE -LRB- SVP -RRB- in controlling flowering time of Brassica plants .
22659182	0	SHORT_VEGETATIVE_PHASE	0,22	SVP	24,27	SHORT VEGETATIVE PHASE	SVP	816787(Tax:3702)	816787(Tax:3702)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	SHORT_VEGETATIVE_PHASE -LRB- SVP -RRB- protein negatively regulates miR172 transcription via direct binding to the pri-miR172a promoter in Arabidopsis .
26243615	0	SHORT_VEGETATIVE_PHASE	0,22	TEMPRANILLO2	36,48	SHORT VEGETATIVE PHASE	TEMPRANILLO2	816787(Tax:3702)	843216(Tax:3702)	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	SHORT_VEGETATIVE_PHASE up-regulates TEMPRANILLO2 floral repressor at low ambient temperatures .
26243615	0	SHORT_VEGETATIVE_PHASE	0,22	TEMPRANILLO2	36,48	SHORT VEGETATIVE PHASE	TEMPRANILLO2	816787(Tax:3702)	843216(Tax:3702)	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	SHORT_VEGETATIVE_PHASE up-regulates TEMPRANILLO2 floral repressor at low ambient temperatures .
17881654	0	SHOX	67,71	BNP	0,3	SHOX	BNP	6473	4879	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	BNP is a transcriptional target of the short stature homeobox gene SHOX .
21273290	0	SHOX	55,59	FGFR3	0,5	SHOX	FGFR3	6473	2261	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	FGFR3 is a target of the homeobox transcription factor SHOX in limb development .
23028966	0	SHOX	58,62	HOXA9	34,39	SHOX	HOXA9	6473	3205	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The homeobox transcription factor HOXA9 is a regulator of SHOX in U2OS cells and chicken micromass cultures .
20412871	0	SHOX	64,68	PAR1	36,40	SHOX	PAR1	6473	145624	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Identification of the first de novo PAR1 deletion downstream of SHOX in an individual diagnosed with L __ ri-Weill_dyschondrosteosis -LRB- LWD -RRB- .
16175500	0	SHOX	66,70	Pseudoautosomal_region_1	17,41	SHOX	Pseudoautosomal region 1	6473	145624	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	A novel class of Pseudoautosomal_region_1 deletions downstream of SHOX is associated with Leri-Weill_dyschondrosteosis .
21262861	0	SHOX	0,4	SOX5	59,63	SHOX	SOX5	6473	6660	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer .
25967354	0	SHOX	74,78	Stature_Homeobox-Containing	45,72	SHOX	Stature Homeobox-Containing	6473	6473	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Radiological Features in Patients with Short Stature_Homeobox-Containing -LRB- SHOX -RRB- Gene Deficiency_and_Turner_Syndrome before and after 2 Years of GH Treatment .
25331797	0	SHOX2	12,17	Aid	36,39	SHOX2	Aid	6474	57379	Gene	Gene	Methylation|compound|START_ENTITY Methylation|nmod|END_ENTITY	Analysis of SHOX2 Methylation as an Aid to Cytology in Lung_Cancer Diagnosis .
22108652	0	SHOX2	56,61	aid	70,73	SHOX2	aid	6474	57379	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung_cancer based on the analysis of bronchial aspirates .
24746361	0	SHOX2	0,5	miR-375	18,25	SHOX2	miR-375	6474	494324	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast_cancer cells .
9867849	0	SHP	28,31	ERalpha	106,113	SHP	ERalpha	117274(Tax:10116)	24890(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta .
15521018	0	SHP	21,24	FXR	74,77	SHP	FXR	117274(Tax:10116)	60351(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver_fibrosis .
18842595	0	SHP	92,95	FXR	74,77	SHP	FXR	23957(Tax:10090)	20186(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	The p300 acetylase is critical for ligand-activated farnesoid_X_receptor -LRB- FXR -RRB- induction of SHP .
24498423	0	SHP	20,23	FXR	6,9	SHP	FXR	8431	9971	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Human FXR regulates SHP expression through direct binding to an LRH-1 binding site , independent of an IR-1 and LRH-1 .
11890664	0	SHP	25,28	HNF-4alpha	67,77	SHP	HNF-4alpha	8431	3172	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Nuclear translocation of SHP and visualization of interaction with HNF-4alpha in living cells .
20930048	0	SHP	36,39	Nrf2	21,25	SHP	Nrf2	23957(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism .
16213225	0	SHP	28,31	PGC-1alpha	42,52	SHP	PGC-1alpha	23957(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes .
17601490	0	SHP	30,33	PPAR-gamma	37,47	SHP	PPAR-gamma	8431	5468	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of SHP by PPAR-gamma in liver .
26421305	0	SHP	20,23	TCF21	6,11	SHP	TCF21	8431	6943	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	POD-1 / TCF21 Reduces SHP Expression , Affecting LRH-1 Regulation and Cell Cycle Balance in Adrenocortical and Hepatocarcinoma_Tumor Cells .
18007036	0	SHP	75,78	androgen_receptor	24,41	SHP	androgen receptor	8431	367	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between the androgen_receptor and a segment of its corepressor SHP .
18842595	0	SHP	92,95	farnesoid_X_receptor	52,72	SHP	farnesoid X receptor	23957(Tax:10090)	20186(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	The p300 acetylase is critical for ligand-activated farnesoid_X_receptor -LRB- FXR -RRB- induction of SHP .
18776219	0	SHP	88,91	miR-433	41,48	SHP	miR-433	8431	574034	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma .
21701493	0	SHP-1	13,18	CD5	34,37	SHP-1	CD5	5777	921	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell_chronic_lymphocytic_leukemia cells .
9590210	0	SHP-1	66,71	CD72	27,31	SHP-1	CD72	5777	971	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation .
11544253	0	SHP-1	117,122	G6b	0,3	SHP-1	G6b	5777	80739	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	G6b , a novel immunoglobulin superfamily member encoded in the human major histocompatibility complex , interacts with SHP-1 and SHP-2 .
11858824	0	SHP-1	92,97	GM-CSF	146,152	SHP-1	GM-CSF	5777	1437	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nmod|END_ENTITY	Molecular assembly of CD46 with CD9 , alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF .
20145200	0	SHP-1	29,34	IL-12p40	68,76	SHP-1	IL-12p40	15170(Tax:10090)	16160(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase .
18391954	0	SHP-1	12,17	IRAK1	109,114	SHP-1	IRAK1	8431	3654	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	Phosphatase SHP-1 promotes TLR - and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1 .
23296072	0	SHP-1	32,37	JAK1	38,42	SHP-1	JAK1	5777	3716	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Structure-guided studies of the SHP-1 / JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition .
24762999	0	SHP-1	58,63	JAK3	65,69	SHP-1	JAK3	5777	3718	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	-LSB- Effect of arsenic_trioxide and 5-aza-2 ' - deoxycytidine on SHP-1 , JAK3 , TYK2 gene expression in K562 cells -RSB- .
10772872	0	SHP-1	47,52	Jak2	71,75	SHP-1	Jak2	5777	3717	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	SH2-Containing_protein_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- association with Jak2 in UT-7 / Epo cells .
9565368	0	SHP-1	105,110	NKG2-A	162,168	SHP-1	NKG2-A	116689(Tax:10116)	29683(Tax:10116)	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	Specific engagement of the CD94/NKG2-A killer inhibitory receptor by the HLA-E class Ib molecule induces SHP-1 phosphatase recruitment to tyrosine-phosphorylated NKG2-A : evidence for receptor function in heterologous transfectants .
10660620	0	SHP-1	92,97	PILRalpha	0,9	SHP-1	PILRalpha	5777	29992	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	PILRalpha , a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein , recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta .
10327049	0	SHP-1	96,101	Paired_immunoglobulin-like_receptor_B	0,37	SHP-1	Paired immunoglobulin-like receptor B	8431	11025	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Paired_immunoglobulin-like_receptor_B -LRB- PIR-B -RRB- inhibits BCR-induced activation of Syk and Btk by SHP-1 .
10772872	0	SHP-1	47,52	SH2-Containing_protein_tyrosine_phosphatase-1	0,45	SHP-1	SH2-Containing protein tyrosine phosphatase-1	5777	5777	Gene	Gene	association|appos|START_ENTITY association|amod|END_ENTITY	SH2-Containing_protein_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- association with Jak2 in UT-7 / Epo cells .
10497187	0	SHP-1	40,45	SHP-1L	13,19	SHP-1	SHP-1L	5777	5777	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity .
9712903	0	SHP-1	100,105	SHPS-1	39,45	SHP-1	SHPS-1	19261(Tax:10090)	19261(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages .
9765283	0	SHP-1	32,37	SLP-76	0,6	SHP-1	SLP-76	5777	3937	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors .
19937797	0	SHP-1	101,106	STAT3	26,31	SHP-1	STAT3	5777	6774	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Betulinic_acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple_myeloma cells .
21818116	0	SHP-1	71,76	STAT3	27,32	SHP-1	STAT3	8431	6774	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|activation activation|nmod|END_ENTITY	Constitutive activation of STAT3 in S __ zary_syndrome is independent of SHP-1 .
15613279	0	SHP-1	0,5	STAT6	16,21	SHP-1	STAT6	23957(Tax:10090)	20852(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner .
12972574	0	SHP-1	84,89	Src	17,20	SHP-1	Src	5777	6714	Gene	Gene	activation|nmod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation .
24762999	0	SHP-1	58,63	TYK2	71,75	SHP-1	TYK2	5777	7297	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	-LSB- Effect of arsenic_trioxide and 5-aza-2 ' - deoxycytidine on SHP-1 , JAK3 , TYK2 gene expression in K562 cells -RSB- .
8638162	0	SHP-1	31,36	ZAP-70	21,27	SHP-1	ZAP-70	5777	7535	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling .
12571228	0	SHP-1	70,75	beta-catenin	23,35	SHP-1	beta-catenin	5777	1499	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells .
11302725	0	SHP-1	99,104	c-Jun_NH2-terminal_kinase	69,94	SHP-1	c-Jun NH2-terminal kinase	15170(Tax:10090)	26419(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Effect of angiotensin_II_type_2_receptor on tyrosine kinase Pyk2 and c-Jun_NH2-terminal_kinase via SHP-1 tyrosine phosphatase activity : evidence from vascular-targeted transgenic_mice of AT2_receptor .
9287352	0	SHP-1	63,68	epidermal_growth_factor	72,95	SHP-1	epidermal growth factor	5777	1950	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal_growth_factor - and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells .
10914554	0	SHP-1	55,60	granulocyte_colony-stimulating_factor	75,112	SHP-1	granulocyte colony-stimulating factor	15170(Tax:10090)	12985(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and modulates signaling from the G-CSF_receptor .
9520455	0	SHP-1	104,109	interleukin_2	72,85	SHP-1	interleukin 2	5777	3558	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression Recruitment|dep|loss Recruitment|nmod|SHP-1 SHP-1|nmod|receptor receptor|amod|END_ENTITY	Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin_2 receptor ; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells .
9520455	0	SHP-1	59,64	interleukin_2	72,85	SHP-1	interleukin 2	5777	3558	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin_2 receptor ; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells .
11160222	0	SHP-1	28,33	leukocyte-associated_Ig-like_receptor-1	39,78	SHP-1	leukocyte-associated Ig-like receptor-1	5777	3903	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Constitutive association of SHP-1 with leukocyte-associated_Ig-like_receptor-1 in human T cells .
19749791	0	SHP-1	14,19	p53	34,37	SHP-1	p53	8431	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast_cancer cell proliferation .
10585470	0	SHP-1	0,5	p62	20,23	SHP-1	p62	5777	23636	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	SHP-1 regulation of p62 -LRB- DOK -RRB- tyrosine phosphorylation in macrophages .
10488096	0	SHP-1	0,5	phosphatidylinositol_3-kinase	28,57	SHP-1	phosphatidylinositol 3-kinase	5777	5295	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	SHP-1 regulates Lck-induced phosphatidylinositol_3-kinase phosphorylation and activity .
10497187	0	SHP-1L	13,19	SHP-1	40,45	SHP-1L	SHP-1	5777	5777	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity .
24088816	0	SHP-2	8,13	CD4	26,29	SHP-2	CD4	19247(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Loss of SHP-2 activity in CD4 + T cells promotes melanoma progression and metastasis .
21918362	0	SHP-2	58,63	Caveolin-1	0,10	SHP-2	Caveolin-1	5781	857	Gene	Gene	activation|compound|START_ENTITY involved|nmod|activation involved|nsubjpass|END_ENTITY	Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes .
23822953	0	SHP-2	56,61	DDR2	102,106	SHP-2	DDR2	5781	4921	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Phosphoproteomics of collagen_receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung_cancer mutants .
15546884	0	SHP-2	14,19	DOK1	0,4	SHP-2	DOK1	5781	1796	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like_growth_factor_I signaling in cultured vascular smooth muscle cells .
9344856	0	SHP-2	105,110	Epidermal_growth_factor	0,23	SHP-2	Epidermal growth factor	5781	1950	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
10212213	0	SHP-2	85,90	Fyn	0,3	SHP-2	Fyn	477488(Tax:9615)	475032(Tax:9615)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|dobj|activation	Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells .
16360206	0	SHP-2	73,78	Granulocyte_macrophage-colony_stimulating_factor	0,48	SHP-2	Granulocyte macrophage-colony stimulating factor	5781	1437	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Granulocyte_macrophage-colony_stimulating_factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils : a new mechanism of action for SHP-2 .
15026337	0	SHP-2	37,42	Grb2-associated_binder_1	12,36	SHP-2	Grb2-associated binder 1	19247(Tax:10090)	14388(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY Role|dep|interaction Role|nmod|END_ENTITY	Role of the Grb2-associated_binder_1 / SHP-2 interaction in cell growth and transformation .
15356145	0	SHP-2	117,122	Grb2-associated_binder_2	19,43	SHP-2	Grb2-associated binder 2	5781	9846	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Grb2-associated_binder_2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation .
15666191	0	SHP-2	0,5	IL-1beta	134,142	SHP-2	IL-1beta	19247(Tax:10090)	16176(Tax:10090)	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin , dephosphorylation of FAK and secretion of MMP-9 induced by IL-1beta in vivo and in vitro .
9129156	0	SHP-2	50,55	Interleukin-2	0,13	SHP-2	Interleukin-2	5781	3558	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation of SHP-2 through IL-2_receptor beta chain .
17214991	0	SHP-2	0,5	PTPN11	27,33	SHP-2	PTPN11	5781	5781	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women .
21393858	0	SHP-2	0,5	PTPN11	6,12	SHP-2	PTPN11	19247(Tax:10090)	19247(Tax:10090)	Gene	Gene	START_ENTITY|appos|mediates mediates|nsubj|END_ENTITY	SHP-2 / PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans .
10681522	0	SHP-2	30,35	PZR	41,44	SHP-2	PZR	5781	9019	Gene	Gene	interaction|nmod|START_ENTITY Dissecting|dobj|interaction Dissecting|nmod|END_ENTITY	Dissecting the interaction of SHP-2 with PZR , an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs .
12410637	0	SHP-2	58,63	PZR	82,85	SHP-2	PZR	5781	9019	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor , PZR : identification , molecular cloning and effects on cell migration .
17440960	0	SHP-2	27,32	PZR	51,54	SHP-2	PZR	19247(Tax:10090)	9019	Gene	Gene	molecule|compound|START_ENTITY ortholog|nmod|molecule accelerates|nsubj|ortholog accelerates|nsubj|END_ENTITY	The murine ortholog of the SHP-2 binding molecule , PZR accelerates cell migration on fibronectin and is expressed in early embryo formation .
9792637	0	SHP-2	112,117	PZR	28,31	SHP-2	PZR	5781	9019	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and cloning of PZR , a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2 .
22278918	0	SHP-2	0,5	ROCK	15,19	SHP-2	ROCK	5781	6093	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton .
11493654	0	SHP-2	0,5	SHP-2_substrate-1	33,50	SHP-2	SHP-2 substrate-1	5781	140885	Gene	Gene	formation|compound|START_ENTITY formation|nmod|END_ENTITY	SHP-2 complex formation with the SHP-2_substrate-1 during C2C12 myogenesis .
8943344	0	SHP-2	105,110	SHPS-1	31,37	SHP-2	SHPS-1	25622(Tax:10116)	25528(Tax:10116)	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|glycoprotein glycoprotein|appos|END_ENTITY	A novel membrane glycoprotein , SHPS-1 , that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion .
9344856	0	SHP-2	105,110	SHPS-1	67,73	SHP-2	SHPS-1	5781	140885	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	SHP-2	105,110	SHPS-1	93,99	SHP-2	SHPS-1	5781	140885	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9582366	0	SHP-2	78,83	SHPS-1	46,52	SHP-2	SHPS-1	5781	140885	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2 .
11088001	0	SHP-2	172,177	Somatostatin_receptor_1	0,23	SHP-2	Somatostatin receptor 1	5781	6751	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Somatostatin_receptor_1 -LRB- SSTR1 -RRB- - mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade : role of the phosphotyrosine phosphatase SHP-2 .
17971444	0	SHP-2	83,88	afadin	68,74	SHP-2	afadin	19247(Tax:10090)	17356(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2 : implications for cellular morphology .
24632723	0	SHP-2	0,5	caveolin-1	15,25	SHP-2	caveolin-1	5781	857	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes .
25672415	0	SHP-2	93,98	caveolin-1	36,46	SHP-2	caveolin-1	5781	857	Gene	Gene	domain|nmod|START_ENTITY dependent|nmod|domain dependent|nsubj|interaction interaction|nmod|END_ENTITY	Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2 .
9285712	0	SHP-2	33,38	ciliary_neurotrophic_factor	60,87	SHP-2	ciliary neurotrophic factor	5781	1270	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|induction induction|compound|END_ENTITY	The protein tyrosine phosphatase SHP-2 negatively regulates ciliary_neurotrophic_factor induction of gene expression .
15133037	0	SHP-2	74,79	epidermal_growth_factor	104,127	SHP-2	epidermal growth factor	5781	1950	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	The major_vault_protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal_growth_factor signaling .
9442080	0	SHP-2	66,71	growth_hormone	75,89	SHP-2	growth hormone	19247(Tax:10090)	14599(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth_hormone signaling .
11340297	0	SHP-2	154,159	interleukin-2	40,53	SHP-2	interleukin-2	5781	3558	Gene	Gene	phosphorylated|nmod|START_ENTITY phosphorylated|nmod|cells cells|amod|tyrosine tyrosine|nmod|END_ENTITY	Gab2 is phosphorylated on tyrosine upon interleukin-2 / interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a .
15170389	0	SHP-2	40,45	interleukin-2	130,143	SHP-2	interleukin-2	5781	3558	Gene	Gene	Interaction|nmod|START_ENTITY regulates|nsubj|Interaction regulates|nmod|END_ENTITY	Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2 .
11342028	0	SHP-2	58,63	leptin_receptor	77,92	SHP-2	leptin receptor	5781	3953	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nmod|END_ENTITY	A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin_receptor .
12531430	0	SHP-2	24,29	prolactin_receptor	48,66	SHP-2	prolactin receptor	5781	5618	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	The adaptor function of SHP-2 downstream of the prolactin_receptor is required for the recruitment of p29 , a substrate of SHP-2 .
11493654	0	SHP-2_substrate-1	33,50	SHP-2	0,5	SHP-2 substrate-1	SHP-2	140885	5781	Gene	Gene	formation|nmod|START_ENTITY formation|compound|END_ENTITY	SHP-2 complex formation with the SHP-2_substrate-1 during C2C12 myogenesis .
10747947	0	SHP1	45,49	CCR5	24,28	SHP1	CCR5	8431	1234	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Beta-chemokine receptor CCR5 signals through SHP1 , SHP2 , and Syk .
26508024	0	SHP1	101,105	SH2-containing_protein_tyrosine_phosphatase_1	54,99	SHP1	SH2-containing protein tyrosine phosphatase 1	5777	5777	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation and anti-tumorigenic effects of SH2-containing_protein_tyrosine_phosphatase_1 -LRB- SHP1 -RRB- in human gastric_cancer cells .
21903867	0	SHP2	21,25	ACSL4	74,79	SHP2	ACSL4	5781	2182	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4 .
17395158	0	SHP2	20,24	Annexin_II	0,10	SHP2	Annexin II	5781	302	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Annexin_II binds to SHP2 and this interaction is regulated by HSP70 levels .
25876044	0	SHP2	25,29	CUB_Domain-Containing_Protein-1	46,77	SHP2	CUB Domain-Containing Protein-1	5781	64866	Gene	Gene	Associates|compound|START_ENTITY Associates|nmod|END_ENTITY	The Tyrosine Phosphatase SHP2 Associates with CUB_Domain-Containing_Protein-1 -LRB- CDCP1 -RRB- , Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner .
25876044	0	SHP2	25,29	CUB_Domain-Containing_Protein-1	46,77	SHP2	CUB Domain-Containing Protein-1	5781	64866	Gene	Gene	Associates|compound|START_ENTITY Associates|nmod|END_ENTITY	The Tyrosine Phosphatase SHP2 Associates with CUB_Domain-Containing_Protein-1 -LRB- CDCP1 -RRB- , Regulating Its Expression at the Cell Surface in a Phosphorylation-Dependent Manner .
20855525	0	SHP2	0,4	Fyn	42,45	SHP2	Fyn	5781	2534	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|downstream downstream|compound|END_ENTITY	SHP2 mediates the localized activation of Fyn downstream of the a6b4 integrin to promote carcinoma_invasion .
26359300	0	SHP2	73,77	GAB1	89,93	SHP2	GAB1	5781	2549	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	EGF augments TGFb-induced epithelial-mesenchymal transition by promoting SHP2 binding to GAB1 .
17097051	0	SHP2	15,19	HSP70	0,5	SHP2	HSP70	5781	3308	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway .
19393645	0	SHP2	47,51	Hepatocyte_growth_factor	0,24	SHP2	Hepatocyte growth factor	19247(Tax:10090)	15234(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- signals through SHP2 to regulate primary mouse myoblast proliferation .
12543077	0	SHP2	0,4	IL-2	15,19	SHP2	IL-2	5781	3558	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	SHP2 regulates IL-2 induced MAPK activation , but not Stat3 or Stat5 tyrosine phosphorylation , in cutaneous_T_cell_lymphoma cells .
9361008	0	SHP2	70,74	Interleukin-3	0,13	SHP2	Interleukin-3	19247(Tax:10090)	16187(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and phosphatidylinositol 3-kinase with a 100-kDa tyrosine-phosphorylated protein in hemopoietic cells .
9794795	0	SHP2	47,51	Jak1	141,145	SHP2	Jak1	5781	3716	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression .
20308328	0	SHP2	30,34	PTPN11	22,28	SHP2	PTPN11	5781	5781	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Functional effects of PTPN11 -LRB- SHP2 -RRB- mutations causing LEOPARD_syndrome on epidermal growth factor-induced phosphoinositide_3-kinase / AKT/glycogen _ synthase_kinase_3beta signaling .
17664338	0	SHP2	89,93	RhoGAP	35,41	SHP2	RhoGAP	5781	392	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The neurite outgrowth multiadaptor RhoGAP , NOMA-GAP , regulates neurite extension through SHP2 and Cdc42 .
21670473	0	SHP2	20,24	STAT5	28,33	SHP2	STAT5	5781	6776	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation , survival , and differentiation of human CD34 + cells .
23057634	0	SHP2	29,33	TGF-b1	44,50	SHP2	TGF-b1	19247(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Protein tyrosine phosphatase SHP2 regulates TGF-b1 production in airway epithelia and asthmatic airway remodeling in mice .
20846526	0	SHP2	0,4	ZAP70	31,36	SHP2	ZAP70	19247(Tax:10090)	22637(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells .
16767162	0	SHP2	51,55	alpha-catenin	14,27	SHP2	alpha-catenin	5781	1495	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3 .
15556604	0	SHP2	0,4	catalase	11,19	SHP2	catalase	5781	847	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	SHP2 binds catalase and acquires a hydrogen_peroxide-resistant phosphatase activity via integrin-signaling .
16690621	0	SHP2	37,41	focal_adhesion_kinase	45,66	SHP2	focal adhesion kinase	25622(Tax:10116)	25614(Tax:10116)	Gene	Gene	START_ENTITY|nmod|down-regulation down-regulation|amod|END_ENTITY	Role of protein-tyrosine phosphatase SHP2 in focal_adhesion_kinase down-regulation during neutrophil cathepsin_G-induced cardiomyocytes anoikis .
23512980	0	SHP2	25,29	focal_adhesion_kinase	40,61	SHP2	focal adhesion kinase	5781	5747	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	The tyrosine phosphatase SHP2 regulates focal_adhesion_kinase to promote EGF-induced lamellipodia persistence and cell migration .
10777583	0	SHP2	86,90	gp130	111,116	SHP2	gp130	5781	3572	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130 .
14514016	0	SHP2	25,29	p38	51,54	SHP2	p38	19247(Tax:10090)	26416(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase_1 and 3 to foster neuronal survival .
10725722	0	SHPS-1	0,6	CD47	72,76	SHPS-1	CD47	19261(Tax:10090)	16423(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|aggregation aggregation|nmod|cells cells|nmod|interaction interaction|nmod|END_ENTITY	SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47 .
15842360	0	SHPS-1	0,6	CD47	68,72	SHPS-1	CD47	19261(Tax:10090)	16423(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	SHPS-1 negatively regulates integrin alphaIIbbeta3 function through CD47 without disturbing FAK phosphorylation .
21638321	0	SHPS-1	49,55	CD47	41,45	SHPS-1	CD47	19261(Tax:10090)	16423(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|association association|nmod|END_ENTITY	An essential role for the association of CD47 to SHPS-1 in skeletal remodeling .
17999719	0	SHPS-1	37,43	Csk-homologous_kinase	0,21	SHPS-1	Csk-homologous kinase	25528(Tax:10116)	29194(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Csk-homologous_kinase interacts with SHPS-1 and enhances neurite outgrowth of PC12 cells .
9344856	0	SHPS-1	67,73	Epidermal_growth_factor	0,23	SHPS-1	Epidermal growth factor	140885	1950	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	SHPS-1	93,99	Epidermal_growth_factor	0,23	SHPS-1	Epidermal growth factor	140885	1950	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
20643654	0	SHPS-1	24,30	PDK1	0,4	SHPS-1	PDK1	140885	5163	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like_growth_factor-i-stimulated AKT activation and vascular smooth muscle cell survival .
9712903	0	SHPS-1	39,45	SHP-1	100,105	SHPS-1	SHP-1	19261(Tax:10090)	19261(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages .
8943344	0	SHPS-1	31,37	SHP-2	105,110	SHPS-1	SHP-2	25528(Tax:10116)	25622(Tax:10116)	Gene	Gene	glycoprotein|appos|START_ENTITY tyrosine|nsubj|glycoprotein tyrosine|dobj|END_ENTITY	A novel membrane glycoprotein , SHPS-1 , that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion .
9344856	0	SHPS-1	67,73	SHP-2	105,110	SHPS-1	SHP-2	140885	5781	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	SHPS-1	93,99	SHP-2	105,110	SHPS-1	SHP-2	140885	5781	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9582366	0	SHPS-1	46,52	SHP-2	78,83	SHPS-1	SHP-2	140885	5781	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2 .
9344856	0	SHPS-1	67,73	SHPS-1	93,99	SHPS-1	SHPS-1	140885	140885	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
9344856	0	SHPS-1	93,99	SHPS-1	67,73	SHPS-1	SHPS-1	140885	140885	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Epidermal_growth_factor stimulates the tyrosine phosphorylation of SHPS-1 and association of SHPS-1 with SHP-2 , a SH2 domain-containing protein tyrosine phosphatase .
12446684	0	SHPS-1	70,76	signal-regulatory_protein-alpha	26,57	SHPS-1	signal-regulatory protein-alpha	19261(Tax:10090)	19261(Tax:10090)	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	Dominant negative form of signal-regulatory_protein-alpha -LRB- SIRPalpha / SHPS-1 -RRB- inhibits tumor_necrosis_factor-mediated apoptosis by activation of NF-kappa_B .
7768884	0	SHPTP2	29,35	GLUT1	55,60	SHPTP2	GLUT1	5781	6513	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|expression expression|compound|END_ENTITY	Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation .
26474641	0	SHW1	0,4	HY5	20,23	SHW1	HY5	843330(Tax:3702)	830996(Tax:3702)	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	SHW1 Interacts with HY5 and COP1 , and Promotes COP1-mediated Degradation of HY5 During Arabidopsis Seedling Development .
14654780	0	SIAH-1	0,6	CtIP	22,26	SIAH-1	CtIP	6477	5932	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway .
21633900	0	SIAH-1	91,97	Eukaryotic_translation_elongation_factor_1_delta	0,48	SIAH-1	Eukaryotic translation elongation factor 1 delta	6477	1936	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Eukaryotic_translation_elongation_factor_1_delta inhibits the ubiquitin ligase activity of SIAH-1 .
25851994	0	SIAH1	23,28	MiR-107	0,7	SIAH1	MiR-107	6477	406901	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	MiR-107 down-regulates SIAH1 expression in human breast_cancer cells and silencing of miR-107 inhibits tumor growth in a nude mouse model of triple-negative_breast_cancer .
16752048	0	SIAH1	54,59	seven_in_absentia_homolog_1	25,52	SIAH1	seven in absentia homolog 1	6477	6477	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the seven_in_absentia_homolog_1 -LRB- SIAH1 -RRB- gene in Parkinson 's _ disease .
19744480	0	SIAH2	57,62	MYPT1	14,19	SIAH2	MYPT1	6478	4659	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|stability stability|compound|END_ENTITY	Regulation of MYPT1 stability by the E3 ubiquitin ligase SIAH2 .
26580787	0	SIAH2	39,44	Seven_In_Absentia_Homolog_2	46,73	SIAH2	Seven In Absentia Homolog 2	6478	6478	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	The Expression of the Ubiquitin Ligase SIAH2 -LRB- Seven_In_Absentia_Homolog_2 -RRB- Is Increased in Human Lung Cancer .
16229822	0	SIAT8B	86,92	sialyltransferase_8B	64,84	SIAT8B	sialyltransferase 8B	8128	8128	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between polymorphisms in the promoter region of the sialyltransferase_8B -LRB- SIAT8B -RRB- gene and schizophrenia .
16733284	0	SIDS	48,52	Sudden_Infant_Death_Syndrome	18,46	SIDS	Sudden Infant Death Syndrome	3423	3423	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	-LSB- The influence of Sudden_Infant_Death_Syndrome -LRB- SIDS -RRB- risk factors on health , growth and development in the first year of life .
22174421	0	SIDT1	82,87	systemic_RNA_interference-defective-1_transmembrane_family_member_1	13,80	SIDT1	systemic RNA interference-defective-1 transmembrane family member 1	54847	54847	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Homo_sapiens systemic_RNA_interference-defective-1_transmembrane_family_member_1 -LRB- SIDT1 -RRB- protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance .
22952899	0	SIGIRR	101,107	Toll-like_receptor_7	31,51	SIGIRR	Toll-like receptor 7	59307	51284	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	The largely normal response to Toll-like_receptor_7 and 9 stimulation and the enhanced expression of SIGIRR by B cells in systemic_lupus_erythematosus .
24821721	0	SIGIRR	92,98	single_immunoglobulin_interleukin-1_receptor-related_molecule	29,90	SIGIRR	single immunoglobulin interleukin-1 receptor-related molecule	59307	59307	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
24821721	0	SIGIRR	92,98	specificity_protein_1	126,147	SIGIRR	specificity protein 1	59307	6667	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
18725536	0	SIK	16,19	TGFbeta	0,7	SIK	TGFbeta	150094	7040	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TGFbeta induces SIK to negatively regulate type I receptor kinase signaling .
18946175	0	SIK1	25,29	HDAC5	16,21	SIK1	HDAC5	17691(Tax:10090)	15184(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts .
26567857	0	SIK1	41,45	Salt-Inducible_Kinase_1	16,39	SIK1	Salt-Inducible Kinase 1	150094	150094	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	A Novel Role of Salt-Inducible_Kinase_1 -LRB- SIK1 -RRB- in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity .
23393134	0	SIK2	66,70	LKB1	28,32	SIK2	LKB1	23235	6794	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases .
26983400	0	SIK2	0,4	PPARa	31,36	SIK2	PPARa	23235	5465	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	SIK2 regulates fasting-induced PPARa activity and ketogenesis through p300 .
24576898	0	SIK2	0,4	insulin	15,22	SIK2	insulin	23235	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	SIK2 regulates insulin secretion .
8661114	0	SIM	29,32	single-minded	14,27	SIM	single-minded	6493	6493	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The mammalian single-minded -LRB- SIM -RRB- gene : mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome .
18480125	0	SIM2	43,47	myomesin2	76,85	SIM2	myomesin2	6493	9172	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel , non-canonical E-box sequence .
11487528	0	SIN-1	61,66	cyclo-oxygenase-2	13,30	SIN-1	cyclo-oxygenase-2	79109	5743	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production .
7539769	0	SIN-1	49,54	rap1B	40,45	SIN-1	rap1B	79109	5908	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Synergistic phosphorylation of platelet rap1B by SIN-1 and iloprost .
23727834	0	SIN1	95,99	CCDC28B	42,49	SIN1	CCDC28B	79109	79140	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	The Bardet-Biedl_syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex .
8654588	0	SIN1	109,113	SAP1	21,25	SIN1	SAP1	856908(Tax:4932)	856771(Tax:4932)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of yeast SAP1 , a novel member of the ` AAA ' ATPase family of proteins , with the chromatin protein SIN1 .
25305016	0	SIN3A	0,5	aryl_hydrocarbon_receptor	113,138	SIN3A	aryl hydrocarbon receptor	25942	196	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	SIN3A , generally regarded as a transcriptional repressor , is required for induction of gene transcription by the aryl_hydrocarbon_receptor .
11557757	0	SIP	73,76	stress-induced_protein	49,71	SIP	stress-induced protein	60599(Tax:10090)	60599(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular and functional characterization of the stress-induced_protein -LRB- SIP -RRB- gene and its two transcripts generated by alternative splicing .
11430829	0	SIP1	49,53	E-cadherin	68,78	SIP1	E-cadherin	9839	999	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion .
16568083	0	SIP1	26,30	vimentin	14,22	SIP1	vimentin	9839	7431	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vimentin by SIP1 in human epithelial breast_tumor cells .
19723624	0	SIP30	0,5	ERK	22,25	SIP30	ERK	257644(Tax:10116)	24338(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	SIP30 is regulated by ERK in peripheral_nerve_injury-induced neuropathic_pain .
17336901	0	SIPA1L1	70,77	Rap	81,84	SIPA1L1	Rap	562521(Tax:7955)	100002737(Tax:7955)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1 , a Rap GTPase activating protein .
23917203	0	SIPAR	0,5	STAT3	27,32	SIPAR	STAT3	84792	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma .
26026268	0	SIPAR	47,52	STAT3	23,28	SIPAR	STAT3	84792	6774	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Nuclear termination of STAT3 signaling through SIPAR -LRB- STAT3-Interacting_Protein_As_a_Repressor -RRB- - dependent recruitment of T cell tyrosine phosphatase TC-PTP .
12374852	0	SIR2	15,19	SIRT3	0,5	SIR2	SIRT3	22933	23410	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	SIRT3 , a human SIR2 homologue , is an NAD-dependent deacetylase localized to mitochondria .
9507023	0	SIRP	29,33	Growth_hormone	0,14	SIRP	Growth hormone	140885	2688	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Growth_hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association .
24269920	0	SIRPA	32,37	CD47	70,74	SIRPA	CD47	140885	961	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47 , inhibiting phagocytosis against human cells to promote xenogeneic engraftment .
10921027	0	SIRP_alpha	48,58	signal-regulatory_protein_alpha	15,46	SIRP alpha	signal-regulatory protein alpha	140885	140885	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of signal-regulatory_protein_alpha -LRB- SIRP_alpha -RRB- in hepatocellular_carcinoma -RSB- .
21535911	0	SIRPa	93,98	CD47	127,131	SIRPa	CD47	19261(Tax:10090)	961	Gene	Gene	capable|nsubj|START_ENTITY express|xcomp|capable express|nmod|END_ENTITY	Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPa capable of binding to human CD47 .
21535911	0	SIRPa	93,98	CD47	6,10	SIRPa	CD47	19261(Tax:10090)	16423(Tax:10090)	Gene	Gene	capable|nsubj|START_ENTITY express|xcomp|capable survival|acl:relcl|express permits|dobj|survival permits|nsubj|expression expression|compound|END_ENTITY	Human CD47 expression permits survival of porcine cells in immunodeficient mice that express SIRPa capable of binding to human CD47 .
22511785	0	SIRPa	99,104	CD47	145,149	SIRPa	CD47	140885	961	Gene	Gene	signal_regulatory_protein_a|appos|START_ENTITY signal_regulatory_protein_a|appos|site site|nmod|domain domain|nmod|END_ENTITY	Surfactant_protein_D -LRB- Sp-D -RRB- binds to membrane-proximal domain -LRB- D3 -RRB- of signal_regulatory_protein_a -LRB- SIRPa -RRB- , a site distant from binding domain of CD47 , while also binding to analogous region on signal regulatory protein b -LRB- SIRPb -RRB- .
23472187	0	SIRPa	110,115	CD47	24,28	SIRPa	CD47	25528(Tax:10116)	29364(Tax:10116)	Gene	Gene	prevents|nmod|START_ENTITY prevents|nsubj|Expression Expression|nmod|END_ENTITY	Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPa inhibitory signaling in mice .
23801922	0	SIRPa	50,55	CD47	8,12	SIRPa	CD47	140885	961	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of CD47 and Signal_Regulatory_Protein_Alpha -LRB- SIRPa -RRB- in Regulating the Clearance of Viable or Aged Blood Cells .
23990469	0	SIRPa	139,144	CD47	8,12	SIRPa	CD47	19261(Tax:10090)	16423(Tax:10090)	Gene	Gene	signal_regulatory_protein_a|appos|START_ENTITY due|nmod|signal_regulatory_protein_a impairs|xcomp|due impairs|nsubj|Lack Lack|nmod|END_ENTITY	Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal_regulatory_protein_a -LRB- SIRPa -RRB- signaling .
24073274	0	SIRPa	12,17	CD47	6,10	SIRPa	CD47	140885	961	Gene	Gene	mechanism|compound|START_ENTITY END_ENTITY|dep|mechanism	Novel CD47 : SIRPa dependent mechanism for the activation of STAT3 in antigen-presenting cell .
24143245	0	SIRPa	13,18	CD47	167,171	SIRPa	CD47	140885	961	Gene	Gene	membrane|nsubj|START_ENTITY membrane|ccomp|required required|xcomp|mediate mediate|nmod|END_ENTITY	` Clustering ' SIRPa into the plasma membrane lipid microdomains is required for activated monocytes and macrophages to mediate effective cell surface interactions with CD47 .
25305319	0	SIRPa	43,48	CD47	58,62	SIRPa	CD47	19261(Tax:10090)	16423(Tax:10090)	Gene	Gene	Polymorphism|nmod|START_ENTITY controls|nsubj|Polymorphism controls|dobj|END_ENTITY	Polymorphism in the innate immune receptor SIRPa controls CD47 binding and autoimmunity in the nonobese diabetic mouse .
25837251	0	SIRPa	86,91	CD47	38,42	SIRPa	CD47	140885	961	Gene	Gene	Engineering|appos|START_ENTITY Engineering|nmod|Ectodomain Ectodomain|compound|END_ENTITY	`` Velcro '' Engineering of High Affinity CD47 Ectodomain as Signal_Regulatory_Protein_a -LRB- SIRPa -RRB- Antagonists That Enhance Antibody-dependent Cellular Phagocytosis .
26085683	0	SIRPa	70,75	CD47	21,25	SIRPa	CD47	140885	961	Gene	Gene	Clearance|compound|START_ENTITY Formation|nmod|Clearance Formation|compound|END_ENTITY	Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPa Facilitate Apoptotic Cell Clearance by Macrophages .
22747997	0	SIRPa	0,5	nephrin	21,28	SIRPa	nephrin	140885	4868	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SIRPa interacts with nephrin at the podocyte slit_diaphragm .
24795566	0	SIRPa	61,66	paxillin	97,105	SIRPa	paxillin	140885	5829	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Phagocytic receptors activate and immune inhibitory receptor SIRPa inhibits phagocytosis through paxillin and cofilin .
11313266	0	SIRPalpha	33,42	CD47	104,108	SIRPalpha	CD47	140885	961	Gene	Gene	Signal-regulatory_protein_alpha|appos|START_ENTITY involved|nsubjpass|Signal-regulatory_protein_alpha binds|ccomp|involved binds|nmod|END_ENTITY	Signal-regulatory_protein_alpha -LRB- SIRPalpha -RRB- but not SIRPbeta is involved in T-cell activation , binds to CD47 with high affinity , and is expressed on immature CD34 -LRB- + -RRB- CD38 -LRB- - -RRB- hematopoietic cells .
17070842	0	SIRPalpha	23,32	CD47	76,80	SIRPalpha	CD47	140885	961	Gene	Gene	cell|compound|START_ENTITY elements|nmod|cell surface|nsubj|elements surface|xcomp|binding binding|nmod|END_ENTITY	Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47 .
19223164	0	SIRPalpha	33,42	CD47	44,48	SIRPalpha	CD47	140885	961	Gene	Gene	Signal_regulatory_protein_alpha|appos|START_ENTITY /|nsubj|Signal_regulatory_protein_alpha /|dobj|interaction interaction|amod|END_ENTITY	Signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- / CD47 interaction and function .
19703989	0	SIRPalpha	71,80	CD47	11,15	SIRPalpha	CD47	19261(Tax:10090)	16423(Tax:10090)	Gene	Gene	CD103|compound|START_ENTITY mediated|nmod|CD103 mediated|nsubj|role role|nmod|END_ENTITY	A role for CD47 in the development of experimental colitis mediated by SIRPalpha + CD103 - dendritic cells .
20826801	0	SIRPalpha	65,74	CD47	90,94	SIRPalpha	CD47	140885	961	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of cis dimerization of signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- in binding to CD47 .
17369261	0	SIRPalpha	65,74	signal_regulatory_protein_alpha	32,63	SIRPalpha	signal regulatory protein alpha	140885	140885	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The structure of the macrophage signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors .
16081415	0	SIRPbeta1	0,9	homodimer	45,54	SIRPbeta1	homodimer	10326	6647	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration .
24757201	0	SIRT-1	71,77	PGC-1a	78,84	SIRT-1	PGC-1a	93759(Tax:10090)	19017(Tax:10090)	Gene	Gene	network|compound|START_ENTITY network|compound|END_ENTITY	MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1 / PGC-1a network in skeletal muscle .
21239502	0	SIRT-1	21,27	p300	46,50	SIRT-1	p300	23411	2033	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells .
26211444	0	SIRT-3	99,105	PHD-2	106,111	SIRT-3	PHD-2	293615(Tax:10116)	308913(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Minocycline ameliorates hypoxia-induced blood-brain barrier damage by inhibition of HIF-1a through SIRT-3 / PHD-2 degradation pathway .
24147777	0	SIRT1	67,72	ACE2	58,62	SIRT1	ACE2	23411	59272	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Epigenetic regulation of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- by SIRT1 under conditions of cell energy stress .
20655472	0	SIRT1	0,5	ADAM10	80,86	SIRT1	ADAM10	93759(Tax:10090)	11487(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|activating activating|dobj|END_ENTITY	SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10 .
25275164	0	SIRT1	22,27	ADAM10	95,101	SIRT1	ADAM10	23411	102	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|activating activating|dobj|END_ENTITY	Retraction notice to : SIRT1 suppresses b-amyloid production by activating the a-secretase gene ADAM10 .
20217115	0	SIRT1	0,5	AMP-activated_protein_kinase	7,35	SIRT1	AMP-activated protein kinase	23411	5563	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	SIRT1 , AMP-activated_protein_kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise : influence of glucose ingestion .
20421294	0	SIRT1	112,117	AMP-activated_protein_kinase	18,46	SIRT1	AMP-activated protein kinase	23411	5563	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	Macrophage alpha1 AMP-activated_protein_kinase -LRB- alpha1AMPK -RRB- antagonizes fatty_acid-induced inflammation through SIRT1 .
24356447	0	SIRT1	0,5	APE1	60,64	SIRT1	APE1	23411	328	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements .
23852118	0	SIRT1	0,5	ATM	24,27	SIRT1	ATM	93759(Tax:10090)	11920(Tax:10090)	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons .
26177453	0	SIRT1	0,5	ATP6V1B2	38,46	SIRT1	ATP6V1B2	23411	526	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes .
22990594	0	SIRT1	0,5	Akt	97,100	SIRT1	Akt	23411	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway .
24874077	0	SIRT1	79,84	BACE1	18,23	SIRT1	BACE1	23411	23621	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Leptin attenuates BACE1 expression and amyloid-b genesis via the activation of SIRT1 signaling pathway .
20157332	0	SIRT1	21,26	C/EBPalpha	0,10	SIRT1	C/EBPalpha	23411	1050	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	C/EBPalpha regulates SIRT1 expression during adipogenesis .
23474493	0	SIRT1	104,109	CBX8	0,4	SIRT1	CBX8	23411	57332	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	CBX8 suppresses Sirtinol-induced premature senescence in human breast_cancer cells via cooperation with SIRT1 .
23075766	0	SIRT1	0,5	CD40	16,20	SIRT1	CD40	23411	958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	SIRT1 regulates CD40 expression induced by TNF-a via NF - B pathway in endothelial cells .
27035655	0	SIRT1	56,61	CLOCK	0,5	SIRT1	CLOCK	93759(Tax:10090)	12753(Tax:10090)	Gene	Gene	sensitivity|nmod|START_ENTITY regulate|dobj|sensitivity regulate|nsubj|END_ENTITY	CLOCK and BMAL1 regulate muscle insulin sensitivity via SIRT1 in male mice .
21836635	0	SIRT1	36,41	CREB	0,4	SIRT1	CREB	23411	1385	Gene	Gene	expression|nummod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability .
18235501	0	SIRT1	32,37	DBC1	0,4	SIRT1	DBC1	23411	57805	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	DBC1 is a negative regulator of SIRT1 .
18235502	0	SIRT1	39,44	DBC1	48,52	SIRT1	DBC1	23411	57805	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of the deacetylase SIRT1 by DBC1 .
22553202	0	SIRT1	53,58	DBC1	36,40	SIRT1	DBC1	23411	57805	Gene	Gene	activation|compound|START_ENTITY protein|nmod|activation protein|appos|END_ENTITY	Role of deleted_in_breast_cancer_1 -LRB- DBC1 -RRB- protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase .
22735644	0	SIRT1	41,46	DBC1	0,4	SIRT1	DBC1	23411	57805	Gene	Gene	deacetylase|nummod|START_ENTITY inhibits|dobj|deacetylase inhibits|nsubj|phosphorylation phosphorylation|nummod|END_ENTITY	DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage .
23162614	0	SIRT1	50,55	DBC1	0,4	SIRT1	DBC1	23411	57805	Gene	Gene	regulator|nmod|START_ENTITY function|nmod|regulator function|nsubj|END_ENTITY	DBC1 does not function as a negative regulator of SIRT1 in liver_cancer .
23892437	0	SIRT1	12,17	DBC1	35,39	SIRT1	DBC1	23411	57805	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|xcomp|block block|dobj|binding binding|compound|END_ENTITY	Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism .
25146318	0	SIRT1	0,5	DBC1	62,66	SIRT1	DBC1	23411	57805	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|advcl|associated associated|nsubjpass|END_ENTITY	SIRT1 expression is associated with a poor prognosis , whereas DBC1 is associated with favorable outcomes in gastric_cancer .
20071779	0	SIRT1	37,42	Deleted_in_breast_cancer-1	0,26	SIRT1	Deleted in breast cancer-1	93759(Tax:10090)	56710(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Deleted_in_breast_cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver_steatosis in mice .
21841822	0	SIRT1	26,31	FOXO3	64,69	SIRT1	FOXO3	23411	2309	Gene	Gene	FOXO3|nmod|START_ENTITY Deacetylation|nmod|FOXO3 leads|nsubj|Deacetylation leads|nmod|ubiquitination ubiquitination|amod|Skp2-mediated Skp2-mediated|dep|END_ENTITY	Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation .
25158994	0	SIRT1	72,77	FOXO3	21,26	SIRT1	FOXO3	309757(Tax:10116)	294515(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts .
25640014	0	SIRT1	0,5	FOXO3a	101,107	SIRT1	FOXO3a	23411	2309	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	SIRT1 protects against oxidative stress-induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation .
26414199	0	SIRT1	17,22	HDAC4	0,5	SIRT1	HDAC4	23411	9759	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	HDAC4 stabilizes SIRT1 via Sumoylation SIRT1 to delay cellular senescence .
16269335	0	SIRT1	41,46	HIC1	17,21	SIRT1	HIC1	93759(Tax:10090)	15248(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses .
17213307	0	SIRT1	24,29	HIC1	50,54	SIRT1	HIC1	23411	3090	Gene	Gene	transcription|nummod|START_ENTITY transcription|nmod|END_ENTITY	Metabolic regulation of SIRT1 transcription via a HIC1 : CtBP corepressor complex .
25646486	0	SIRT1	53,58	HIC1	79,83	SIRT1	HIC1	23411	3090	Gene	Gene	transcription|nummod|START_ENTITY transcription|nmod|END_ENTITY	Retraction for Zhang et al. , Metabolic regulation of SIRT1 transcription via a HIC1 : CtBP corepressor complex .
23238746	0	SIRT1	0,5	ICAM-1	43,49	SIRT1	ICAM-1	23411	3383	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells .
21781483	0	SIRT1	1,6	IL-1b	16,21	SIRT1	IL-1b	23411	3553	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	-LSB- SIRT1 inhibits IL-1b mRNA transcription in lipopolysaccharide tolerant THP-1 cells -RSB- .
26752489	0	SIRT1	0,5	IL-1b	39,44	SIRT1	IL-1b	23411	3553	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Effect Effect|nmod|END_ENTITY	SIRT1 Inhibits the Catabolic Effect of IL-1b Through TLR2/SIRT1/NF-kB Pathway in Human Degenerative Nucleus Pulposus Cells .
22169038	0	SIRT1	0,5	MAO-A	16,21	SIRT1	MAO-A	23411	4128	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive .
24924687	0	SIRT1	31,36	MiR-132	0,7	SIRT1	MiR-132	23411	406921	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic pathway .
23768087	0	SIRT1	23,28	MiR-204	0,7	SIRT1	MiR-204	23411	406987	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition , anoikis resistance and invasion in gastric_cancer cells .
22308024	0	SIRT1	89,94	MicroRNA-217	0,12	SIRT1	MicroRNA-217	93759(Tax:10090)	387213(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1 .
22364258	0	SIRT1	111,116	MicroRNA-34a	0,12	SIRT1	MicroRNA-34a	23411	407040	Gene	Gene	statins|nmod|START_ENTITY effect|nmod|statins regulates|parataxis|effect regulates|nsubj|END_ENTITY	MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary_artery_disease : effect of statins on SIRT1 and microRNA-34a expression .
22364258	0	SIRT1	56,61	MicroRNA-34a	0,12	SIRT1	MicroRNA-34a	23411	407040	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary_artery_disease : effect of statins on SIRT1 and microRNA-34a expression .
25352462	0	SIRT1	64,69	MicroRNA-34a	0,12	SIRT1	MicroRNA-34a	23411	407040	Gene	Gene	Downregulation|compound|START_ENTITY Senescence|nmod|Downregulation Vascular|dep|Senescence Vascular|compound|END_ENTITY	MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors .
21778425	0	SIRT1	35,40	P66Shc	14,20	SIRT1	P66Shc	93759(Tax:10090)	20416(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial_dysfunction .
21459329	0	SIRT1	17,22	PARP-2	0,6	SIRT1	PARP-2	93759(Tax:10090)	11546(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PARP-2 regulates SIRT1 expression and whole-body energy expenditure .
18573234	0	SIRT1	11,16	PC3	71,74	SIRT1	PC3	23411	5122	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for SIRT1 in cell growth and chemoresistance in prostate_cancer PC3 and DU145 cells .
25614670	0	SIRT1	35,40	PGC-1a	52,58	SIRT1	PGC-1a	23411	10891	Gene	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1a / PPAR-a Signaling .
25614670	0	SIRT1	35,40	PPAR-a	59,65	SIRT1	PPAR-a	23411	5465	Gene	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1a / PPAR-a Signaling .
23827175	0	SIRT1	17,22	Resistin	0,8	SIRT1	Resistin	93759(Tax:10090)	57264(Tax:10090)	Gene	Gene	function|compound|START_ENTITY impairs|dobj|function impairs|nsubj|END_ENTITY	Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes .
22357324	0	SIRT1	105,110	SIRT1	35,40	SIRT1	SIRT1	309757(Tax:10116)	309757(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells : an implicative role of SIRT1 in the ovary .
22357324	0	SIRT1	35,40	SIRT1	105,110	SIRT1	SIRT1	309757(Tax:10116)	309757(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells : an implicative role of SIRT1 in the ovary .
19690166	0	SIRT1	43,48	SMILE	28,33	SIRT1	SMILE	23411	58487	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen_receptor-related_receptor_gamma transactivation .
25132403	0	SIRT1	0,5	SOX2	25,29	SIRT1	SOX2	23411	6657	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SIRT1 directly regulates SOX2 to maintain self-renewal and multipotency in bone marrow-derived mesenchymal stem cells .
25270091	0	SIRT1	0,5	SREBP1	53,59	SIRT1	SREBP1	23411	6720	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	SIRT1 promotes endometrial_tumor_growth by targeting SREBP1 and lipogenesis .
18004385	0	SIRT1	0,5	SUV39H1	47,54	SIRT1	SUV39H1	23411	6839	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation .
25554355	0	SIRT1	52,57	Silent_Information_Regulator_1	20,50	SIRT1	Silent Information Regulator 1	23411	23411	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between Silent_Information_Regulator_1 -LRB- SIRT1 -RRB- gene polymorphisms and schizophrenia in a Chinese Han population .
16257164	0	SIRT1	11,16	Sirtuin_1	0,9	SIRT1	Sirtuin 1	23411	23411	Gene	Gene	variation|appos|START_ENTITY variation|amod|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- sequence variation is not associated with exceptional human longevity .
20339025	0	SIRT1	8,13	Sirtuin_1	25,34	SIRT1	Sirtuin 1	23411	23411	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Lack of SIRT1 -LRB- Mammalian Sirtuin_1 -RRB- activity leads to liver_steatosis in the SIRT1 + / - mice : a role of lipid mobilization and inflammation .
21540183	0	SIRT1	11,16	Sirtuin_1	0,9	SIRT1	Sirtuin 1	93759(Tax:10090)	93759(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- protein degradation in response to persistent c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation contributes to hepatic_steatosis in obesity .
24466304	0	SIRT1	11,16	Sirtuin_1	0,9	SIRT1	Sirtuin 1	93759(Tax:10090)	93759(Tax:10090)	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice .
26656366	0	SIRT1	50,55	Sirtuin_1	39,48	SIRT1	Sirtuin 1	23411	23411	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Single Nucleotide Polymorphisms of the Sirtuin_1 -LRB- SIRT1 -RRB- Gene are Associated With age-Related Macular_Degeneration in Chinese Han Individuals : A Case-Control Pilot Study .
20160399	0	SIRT1	35,40	Sp1	64,67	SIRT1	Sp1	23411	6667	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1 .
20100829	0	SIRT1	0,5	TIP60	74,79	SIRT1	TIP60	23411	10524	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60 .
25770475	0	SIRT1	15,20	TNFa	0,4	SIRT1	TNFa	93759(Tax:10090)	21926(Tax:10090)	Gene	Gene	Cleavage|compound|START_ENTITY Cleavage|compound|END_ENTITY	TNFa Regulates SIRT1 Cleavage during Ocular Autoimmune_Disease .
25541949	0	SIRT1	64,69	Unc-51-Like_Kinase_1	16,36	SIRT1	Unc-51-Like Kinase 1	93759(Tax:10090)	22241(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of Unc-51-Like_Kinase_1 by Nitric_Oxide Stabilizes SIRT1 , Independent of Autophagy .
24100623	0	SIRT1	0,5	activating_transcription_factor_4	17,50	SIRT1	activating transcription factor 4	23411	468	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	SIRT1 suppresses activating_transcription_factor_4 -LRB- ATF4 -RRB- expression in response to proteasome inhibition .
20042607	0	SIRT1	0,5	activator_protein-1	17,36	SIRT1	activator protein-1	23411	3725	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|amod|END_ENTITY	SIRT1 suppresses activator_protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages .
24147777	0	SIRT1	67,72	angiotensin-converting_enzyme_2	25,56	SIRT1	angiotensin-converting enzyme 2	23411	59272	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- by SIRT1 under conditions of cell energy stress .
18823944	0	SIRT1	51,56	c-JUN	42,47	SIRT1	c-JUN	23411	3725	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of transcriptional activity of c-JUN by SIRT1 .
18662537	0	SIRT1	0,5	clock	42,47	SIRT1	clock	23411	9575	Gene	Gene	deacetylase|nsubj|START_ENTITY deacetylase|nmod|components components|compound|END_ENTITY	SIRT1 is a circadian deacetylase for core clock components .
18662546	0	SIRT1	0,5	clock	26,31	SIRT1	clock	23411	9575	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SIRT1 regulates circadian clock gene expression through PER2 deacetylation .
20960276	0	SIRT1	83,88	insulin	53,60	SIRT1	insulin	23411	3630	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells .
22691943	0	SIRT1	24,29	mIGF-1	17,23	SIRT1	mIGF-1	93759(Tax:10090)	16000(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling END_ENTITY|parataxis|induces	Cardioprotective mIGF-1 / SIRT1 signaling induces hypertension , leukocytosis and fear response in mice .
25108014	0	SIRT1	48,53	mIGF-1	41,47	SIRT1	mIGF-1	93759(Tax:10090)	16000(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	The TRPA1 channel is a cardiac target of mIGF-1 / SIRT1 signaling .
20169165	0	SIRT1	0,5	mammalian_target_of_rapamycin	31,60	SIRT1	mammalian target of rapamycin	23411	2475	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SIRT1 negatively regulates the mammalian_target_of_rapamycin .
23038275	0	SIRT1	0,5	matrix_metalloproteinase-2	15,41	SIRT1	matrix metalloproteinase-2	23411	4313	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	SIRT1 enhances matrix_metalloproteinase-2 expression and tumor cell invasion in prostate_cancer cells .
21596753	0	SIRT1	19,24	miR-200a	0,8	SIRT1	miR-200a	23411	406983	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition -LRB- EMT -RRB- - like transformation in mammary epithelial cells .
26662303	0	SIRT1	108,113	miR-22	0,6	SIRT1	miR-22	23411	407004	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-22 inhibits the proliferation , motility , and invasion of human glioblastoma cells by directly targeting SIRT1 .
26912776	0	SIRT1	68,73	miR-22	0,6	SIRT1	miR-22	93759(Tax:10090)	387141(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-22 inhibits mouse ovarian granulosa cell apoptosis by targeting SIRT1 .
26964730	0	SIRT1	70,75	miR-22	61,67	SIRT1	miR-22	23411	407004	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	PDE5 inhibition ameliorates visceral adiposity targeting the miR-22 / SIRT1 pathway : evidence from the CECSID trial .
18755897	0	SIRT1	22,27	miR-34a	0,7	SIRT1	miR-34a	23411	407040	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	miR-34a repression of SIRT1 regulates apoptosis .
25916635	0	SIRT1	95,100	miR-34a	87,94	SIRT1	miR-34a	93759(Tax:10090)	723848(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Carbon_monoxide protects against hepatic_ischemia / reperfusion injury by modulating the miR-34a / SIRT1 pathway .
26608583	0	SIRT1	130,135	miR-34a	122,129	SIRT1	miR-34a	93759(Tax:10090)	723848(Tax:10090)	Gene	Gene	Axis|compound|START_ENTITY Axis|amod|END_ENTITY	Isocaloric Pair-Fed High-Carbohydrate Diet Induced More Hepatic_Steatosis and Inflammation than High-Fat Diet Mediated by miR-34a / SIRT1 Axis in Mice .
26722316	0	SIRT1	76,81	miR-34a	0,7	SIRT1	miR-34a	23411	407040	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression inhibits|nmod|downregulation inhibits|nsubj|END_ENTITY	miR-34a inhibits cell proliferation in prostate_cancer by downregulation of SIRT1 expression .
26562529	0	SIRT1	83,88	miR-543	23,30	SIRT1	miR-543	23411	100126335	Gene	Gene	targeting|dobj|START_ENTITY alleviates|advcl|targeting alleviates|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1 .
26612257	0	SIRT1	64,69	miR-543	0,7	SIRT1	miR-543	23411	100126335	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-543 promotes gastric_cancer cell proliferation by targeting SIRT1 .
15632193	0	SIRT1	0,5	p300	38,42	SIRT1	p300	23411	2033	Gene	Gene	deacetylation|compound|START_ENTITY deacetylation|nmod|END_ENTITY	SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1 .
11672523	0	SIRT1	6,11	p53	43,46	SIRT1	p53	23411	7157	Gene	Gene	functions|appos|START_ENTITY deacetylase|nsubj|functions deacetylase|nmod|END_ENTITY	hSIR2 -LRB- SIRT1 -RRB- functions as an NAD-dependent p53 deacetylase .
16354677	0	SIRT1	14,19	p53	49,52	SIRT1	p53	23411	7157	Gene	Gene	activity|compound|START_ENTITY Inhibition|nmod|activity increases|nsubj|Inhibition increases|dobj|acetylation acetylation|compound|END_ENTITY	Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage .
16785031	0	SIRT1	32,37	p53	104,107	SIRT1	p53	23411	7157	Gene	Gene	attenuates|appos|START_ENTITY oxidative|nsubj|attenuates oxidative|dobj|apoptosis apoptosis|nmod|deacetylation deacetylation|compound|END_ENTITY	Silent_information_regulator_2 -LRB- SIRT1 -RRB- attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation .
17595514	0	SIRT1	103,108	p53	67,70	SIRT1	p53	23411	7157	Gene	Gene	function|nmod|START_ENTITY decrease|nmod|function END_ENTITY|nmod|decrease	H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD + depletion .
17964266	0	SIRT1	20,25	p53	79,82	SIRT1	p53	23411	7157	Gene	Gene	regulator|nmod|START_ENTITY cooperates|nsubj|regulator cooperates|nmod|suppression suppression|nmod|activity activity|compound|END_ENTITY	Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity .
17964266	0	SIRT1	42,47	p53	79,82	SIRT1	p53	23411	7157	Gene	Gene	suppression|compound|START_ENTITY suppression|nmod|activity activity|compound|END_ENTITY	Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity .
18371449	0	SIRT1	0,5	p53	92,95	SIRT1	p53	93759(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|localization localization|compound|END_ENTITY	SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization .
18681908	0	SIRT1	0,5	p53	84,87	SIRT1	p53	23411	7157	Gene	Gene	confers|nsubj|START_ENTITY confers|dobj|protection protection|nmod|death death|nmod|modulation modulation|nmod|END_ENTITY	SIRT1 confers protection against UVB - and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes .
20931131	0	SIRT1	52,57	p53	61,64	SIRT1	p53	23411	7157	Gene	Gene	activity|nmod|START_ENTITY Measurement|nmod|activity Measurement|nmod|END_ENTITY	Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen technology .
20975832	0	SIRT1	0,5	p53	74,77	SIRT1	p53	23411	7157	Gene	Gene	undergoes|nsubj|START_ENTITY undergoes|nmod|loop loop|nmod|END_ENTITY	SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53 .
21149449	0	SIRT1	90,95	p53	15,18	SIRT1	p53	23411	7157	Gene	Gene	deacetylase|dobj|START_ENTITY deacetylase|nsubj|Suppression Suppression|nmod|activity activity|compound|END_ENTITY	Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1 .
21245319	0	SIRT1	79,84	p53	35,38	SIRT1	p53	23411	7157	Gene	Gene	Sirtuin_1|appos|START_ENTITY interacting|nmod|Sirtuin_1 regulates|advcl|interacting regulates|dobj|activity activity|compound|END_ENTITY	Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin_1 -LRB- SIRT1 -RRB- .
21593185	0	SIRT1	0,5	p53	100,103	SIRT1	p53	93759(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY cisplatin-induced|nsubj|activation cisplatin-induced|nmod|deacetylation deacetylation|nmod|END_ENTITY	SIRT1 activation by resveratrol ameliorates cisplatin-induced renal_injury through deacetylation of p53 .
21968188	0	SIRT1	21,26	p53	0,3	SIRT1	p53	23411	7157	Gene	Gene	deacetylation|nmod|START_ENTITY deacetylation|compound|END_ENTITY	p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence .
22124156	0	SIRT1	24,29	p53	95,98	SIRT1	p53	23411	7157	Gene	Gene	variant|compound|START_ENTITY opposes|nsubj|variant opposes|advcl|regulating regulating|dobj|END_ENTITY	A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes .
22124156	0	SIRT1	58,63	p53	95,98	SIRT1	p53	23411	7157	Gene	Gene	opposes|dobj|START_ENTITY opposes|advcl|regulating regulating|dobj|END_ENTITY	A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes .
22340598	0	SIRT1	21,26	p53	14,17	SIRT1	p53	23411	7157	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Activation of p53 by SIRT1 inhibition enhances elimination of CML_leukemia stem cells in combination with imatinib .
22728651	0	SIRT1	70,75	p53	14,17	SIRT1	p53	23411	7157	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|compound|END_ENTITY	AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver_cancer cells .
22732402	0	SIRT1	14,19	p53	72,75	SIRT1	p53	23411	7157	Gene	Gene	Inhibition|nmod|START_ENTITY results|nsubj|Inhibition results|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway .
23661372	0	SIRT1	18,23	p53	94,97	SIRT1	p53	93759(Tax:10090)	22060(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY promotes|nsubj|Overexpression promotes|dobj|corneal_epithelial_wound_healing corneal_epithelial_wound_healing|nmod|regulation regulation|compound|END_ENTITY	Overexpression of SIRT1 promotes high glucose-attenuated corneal_epithelial_wound_healing via p53 regulation of the IGFBP3/IGF -1 R/AKT pathway .
23846322	0	SIRT1	26,31	p53	17,20	SIRT1	p53	23411	7157	Gene	Gene	YK-3-237|compound|START_ENTITY Targeting|nmod|YK-3-237 Targeting|dobj|END_ENTITY	Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative_breast_cancer cells .
24020002	0	SIRT1	0,5	p53	20,23	SIRT1	p53	23411	7157	Gene	Gene	START_ENTITY|dep|Regulator Regulator|nmod|Deacetylation Deacetylation|compound|END_ENTITY	SIRT1 : Regulator of p53 Deacetylation .
24298365	0	SIRT1	0,5	p53	15,18	SIRT1	p53	93759(Tax:10090)	22060(Tax:10090)	Gene	Gene	Inhibits|compound|START_ENTITY END_ENTITY|nsubj|Inhibits	SIRT1 Inhibits p53 but not NF-kB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies .
24855208	0	SIRT1	0,5	p53	40,43	SIRT1	p53	23411	7157	Gene	Gene	prevents|nsubj|START_ENTITY prevents|dobj|activation activation|compound|END_ENTITY	SIRT1 prevents genotoxic stress-induced p53 activation in acute_myeloid_leukemia .
24959379	0	SIRT1	0,5	p53	64,67	SIRT1	p53	23411	7157	Gene	Gene	phosphorylation|nummod|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|acetylation acetylation|compound|END_ENTITY	SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation .
25389371	0	SIRT1	74,79	p53	122,125	SIRT1	p53	23411	7157	Gene	Gene	S-nitrosylation|nmod|START_ENTITY induce|dobj|S-nitrosylation induce|advcl|increase increase|dobj|acetylation acetylation|nmod|END_ENTITY	Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65 .
25950477	0	SIRT1	40,45	p53	88,91	SIRT1	p53	23411	7157	Gene	Gene	HDAC1|nmod|START_ENTITY Acetylation|nmod|HDAC1 form|nsubj|Acetylation form|xcomp|regulate regulate|dobj|acetylation acetylation|compound|END_ENTITY	Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress .
26515559	0	SIRT1	66,71	p53	31,34	SIRT1	p53	23411	7157	Gene	Gene	dissociation|nmod|START_ENTITY enhanced|nmod|dissociation enhanced|dobj|acetylation acetylation|compound|END_ENTITY	HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis .
26515559	0	SIRT1	66,71	p53	77,80	SIRT1	p53	23411	7157	Gene	Gene	dissociation|nmod|START_ENTITY enhanced|nmod|dissociation enhanced|nmod|END_ENTITY	HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis .
22640422	0	SIRT1	36,41	sirtuin_1	25,34	SIRT1	sirtuin 1	309757(Tax:10116)	309757(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Metabolic programming of sirtuin_1 -LRB- SIRT1 -RRB- expression by moderate energy restriction during gestation in rats may be related to obesity susceptibility in later life .
24145124	0	SIRT1	29,34	sirtuin_1	18,27	SIRT1	sirtuin 1	23411	23411	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of mammalian sirtuin_1 -LRB- SIRT1 -RRB- in lipids metabolism and cell proliferation of goose primary hepatocytes .
24395567	0	SIRT1	32,37	sirtuin_1	21,30	SIRT1	sirtuin 1	309757(Tax:10116)	309757(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Resveratrol restores sirtuin_1 -LRB- SIRT1 -RRB- activity and pyruvate_dehydrogenase_kinase_1 -LRB- PDK1 -RRB- expression after hemorrhagic_injury in a rat model .
19285077	0	SIRT1	0,5	tyrosine_hydroxylase	16,36	SIRT1	tyrosine hydroxylase	23411	7054	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	SIRT1 regulates tyrosine_hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a .
25312940	0	SIRT2	17,22	AK-1	0,4	SIRT2	AK-1	22933	203	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	AK-1 , a specific SIRT2 inhibitor , induces cell cycle arrest by downregulating Snail in HCT116 human colon_carcinoma cells .
26808575	0	SIRT2	8,13	AK-1	0,4	SIRT2	AK-1	22933	203	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	AK-1 , a SIRT2 inhibitor , destabilizes HIF-1a and diminishes its transcriptional activity during hypoxia .
26854234	0	SIRT2	23,28	ATR	36,39	SIRT2	ATR	22933	545	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA .
24825348	0	SIRT2	0,5	BubR1	36,41	SIRT2	BubR1	64383(Tax:10090)	12236(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	SIRT2 induces the checkpoint kinase BubR1 to increase lifespan .
24920578	0	SIRT2	23,28	BubR1	50,55	SIRT2	BubR1	64383(Tax:10090)	12236(Tax:10090)	Gene	Gene	extends|nsubj|START_ENTITY extends|dobj|span span|nmod|mice mice|amod|END_ENTITY	Sirtuin to the rescue : SIRT2 extends life span of BubR1 mice .
25285631	0	SIRT2	71,76	BubR1	103,108	SIRT2	BubR1	22933	701	Gene	Gene	effects|compound|START_ENTITY effects|nmod|degradation degradation|amod|END_ENTITY	Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition .
25285631	0	SIRT2	71,76	BubR1	48,53	SIRT2	BubR1	22933	701	Gene	Gene	effects|compound|START_ENTITY END_ENTITY|nmod|effects	Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition .
25285640	0	SIRT2	30,35	Cbl	0,3	SIRT2	Cbl	22933	867	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Cbl regulates the activity of SIRT2 .
25275824	0	SIRT2	45,50	Sirtuin_2	34,43	SIRT2	Sirtuin 2	22933	22933	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of Potent and Selective Sirtuin_2 -LRB- SIRT2 -RRB- Inhibitors Using a Fragment-Based Approach .
17181175	0	SIRT2	107,112	Sirtuin_Type_2	91,105	SIRT2	Sirtuin Type 2	22933	22933	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	N , N ' - Bisbenzylidenebenzene-1 ,4 - diamines and N , N ' - Bisbenzylidenenaphthalene-1 ,4 - diamines as Sirtuin_Type_2 -LRB- SIRT2 -RRB- Inhibitors .
24996174	0	SIRT2	30,35	Src	0,3	SIRT2	Src	22933	6714	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Src regulates the activity of SIRT2 .
19754813	0	SIRT2	34,39	Wip1	117,121	SIRT2	Wip1	22933	8493	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|effects effects|nmod|END_ENTITY	Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1 .
24438005	0	SIRT2	10,15	keratin_19	25,35	SIRT2	keratin 19	22933	3880	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Mammalian SIRT2 inhibits keratin_19 expression and is a tumor suppressor in skin .
18781224	0	SIRT3	0,5	FOXO3a	40,46	SIRT3	FOXO3a	23410	2309	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria , as well as increases FOXO3a dependent gene expression .
26131100	0	SIRT3	0,5	Notch-1	85,92	SIRT3	Notch-1	23410	4851	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	SIRT3 inhibits cell proliferation in human gastric_cancer through down-regulation of Notch-1 .
26109058	0	SIRT3	37,42	Nuclear_respiratory_factor_2	0,28	SIRT3	Nuclear respiratory factor 2	23410	2553	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Nuclear_respiratory_factor_2 induces SIRT3 expression .
12374852	0	SIRT3	0,5	SIR2	15,19	SIRT3	SIR2	23410	22933	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	SIRT3 , a human SIR2 homologue , is an NAD-dependent deacetylase localized to mitochondria .
23871415	0	SIRT3	11,16	Sirtuin-3	0,9	SIRT3	Sirtuin-3	23410	23410	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sirtuin-3 -LRB- SIRT3 -RRB- expression is associated with overall survival in esophageal_cancer .
25759382	0	SIRT3	11,16	Sirtuin-3	0,9	SIRT3	Sirtuin-3	64384(Tax:10090)	64384(Tax:10090)	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	Sirtuin-3 -LRB- SIRT3 -RRB- Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes .
24121500	0	SIRT3	11,16	Sirtuin_3	0,9	SIRT3	Sirtuin 3	64384(Tax:10090)	64384(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Sirtuin_3 -LRB- SIRT3 -RRB- protein regulates long-chain_acyl-CoA_dehydrogenase by deacetylating conserved lysines near the active site .
26912655	0	SIRT3	0,5	a-SMA	16,21	SIRT3	a-SMA	64384(Tax:10090)	11475(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	SIRT3 regulates a-SMA production through the succinate_dehydrogenase-GPR91 pathway in hepatic stellate cells .
26317998	0	SIRT3	0,5	c-MYC	60,65	SIRT3	c-MYC	23410	4609	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	SIRT3 inhibits prostate_cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway .
24909164	0	SIRT3	0,5	iron_regulatory_protein_1	73,98	SIRT3	iron regulatory protein 1	23410	48	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron_regulatory_protein_1 .
24909164	0	SIRT3	0,5	iron_regulatory_protein_1	73,98	SIRT3	iron regulatory protein 1	23410	48	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron_regulatory_protein_1 .
16484774	0	SIRT5	60,65	sirtuin_5	44,53	SIRT5	sirtuin 5	23408	23408	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the NAD-dependent deacetylase sirtuin_5 gene -LRB- SIRT5 -RRB- to human chromosome band 6p23 by in situ hybridization .
25320180	0	SIRT6	0,5	COX-2	15,20	SIRT6	COX-2	51548	4513	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin_Cancer .
20157594	0	SIRT6	0,5	DNA-dependent_protein_kinase	17,45	SIRT6	DNA-dependent protein kinase	51548	5591	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|END_ENTITY	SIRT6 stabilizes DNA-dependent_protein_kinase at chromatin for DNA double-strand break repair .
25777360	0	SIRT6	15,20	ITCH	0,4	SIRT6	ITCH	50721(Tax:10090)	16396(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice .
23911928	0	SIRT6	0,5	SNF2H	15,20	SIRT6	SNF2H	51548	8467	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	SIRT6 recruits SNF2H to DNA break sites , preventing genomic instability through chromatin remodeling .
24163442	0	SIRT6	38,43	Sirtuin_6	27,36	SIRT6	Sirtuin 6	51548	51548	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	A proteomic perspective of Sirtuin_6 -LRB- SIRT6 -RRB- phosphorylation and interactions and their dependence on its catalytic activity .
23552949	0	SIRT6	0,5	TNF-a	16,21	SIRT6	TNF-a	51548	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl_lysine .
24583844	0	SIRT6	8,13	miR-34a	0,7	SIRT6	miR-34a	51548	407040	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	miR-34a / SIRT6 in squamous differentiation and cancer .
25009184	0	SIRT6	37,42	p53	17,20	SIRT6	p53	50721(Tax:10090)	22060(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion .
26704017	0	SIRT7	28,33	C/EBPa	0,6	SIRT7	C/EBPa	51547	1050	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	C/EBPa negatively regulates SIRT7 expression via recruiting HDAC3 to the upstream-promoter of hepatocellular_carcinoma cells .
26704979	0	SIRT7	21,26	Dicer	0,5	SIRT7	Dicer	51547	23405	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents .
15105421	0	SIVA	22,26	p53	88,91	SIVA	p53	10572	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 .
25813352	0	SIVA	20,24	p53	4,7	SIVA	p53	10572	7157	Gene	Gene	Development|compound|START_ENTITY END_ENTITY|dep|Development	The p53 Target Gene SIVA Enables Non-Small_Cell_Lung_Cancer Development .
20110314	0	SIX1	0,4	TBX18	31,36	SIX1	TBX18	6495	9096	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation .
25157435	0	SIX1	54,58	miR-204	0,7	SIX1	miR-204	6495	406987	Gene	Gene	regulating|dobj|START_ENTITY suppressor|advcl|regulating suppressor|nsubj|functions functions|amod|END_ENTITY	miR-204 functions as a tumor suppressor by regulating SIX1 in NSCLC .
19606496	0	SIX3	98,102	EYA4	0,4	SIX3	EYA4	6496	2070	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	EYA4 , deleted in a case with middle interhemispheric variant of holoprosencephaly , interacts with SIX3 both physically and functionally .
10516439	0	SK1	105,108	KCNN1	115,120	SK1	KCNN1	3780	3780	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene -LRB- KCNN1 -RRB- .
23156743	0	SK2	62,65	KCNN2	67,72	SK2	KCNN2	3781	3781	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Construction and identification of the expression plasmid of SK2 -LRB- KCNN2 -RRB- gene from human atrial myocytes with overlapping PCR -RSB- .
17101631	0	SK3	10,13	DM1	28,31	SK3	DM1	3782	1760	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility .
26460070	0	SKA2	97,101	Endothelin-1	111,123	SKA2	Endothelin-1	66140(Tax:10090)	13614(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Peroxisome Proliferator alpha mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulate Endothelin-1 and PAI-1 expression in sickle_cell_disease .
9534887	0	SKALP	48,53	skin-derived_antileukoproteinase	14,46	SKALP	skin-derived antileukoproteinase	5266	5266	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of skin-derived_antileukoproteinase -LRB- SKALP -RRB- in reconstructed human epidermis and its value as a marker for skin irritation .
26242911	0	SKAP	87,91	IQGAP1	27,33	SKAP	IQGAP1	90417	8826	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration .
20824186	0	SKAP-HOM	21,29	HPK1	0,4	SKAP-HOM	HPK1	54353;51944	26411(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion .
17468262	0	SKD1	27,31	LYST-INTERACTING_PROTEIN5	122,147	SKD1	LYST-INTERACTING PROTEIN5	817306(Tax:3702)	828782(Tax:3702)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The Arabidopsis AAA ATPase SKD1 is involved in multivesicular endosome function and interacts with its positive regulator LYST-INTERACTING_PROTEIN5 .
10679028	0	SKD1	10,14	Vps4p	37,42	SKD1	Vps4p	20479(Tax:10090)	856303(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The mouse SKD1 , a homologue of yeast Vps4p , is required for normal endosomal trafficking and morphology in mammalian cells .
10644367	0	SKIP	11,15	EBNA2	19,24	SKIP	EBNA2	80309	17494192	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|compound|END_ENTITY	A role for SKIP in EBNA2 activation of CBF1-repressed promoters .
26940976	0	SKIP	72,76	Glucose-regulated_protein_78	0,28	SKIP	Glucose-regulated protein 78	51763	3309	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Glucose-regulated_protein_78 -LRB- GRP78 -RRB- binds directly to PIP3 phosphatase SKIP and determines its localization .
15316101	0	SKIP	31,35	MAGE-A1	0,7	SKIP	MAGE-A1	22938	4100	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription .
26384244	0	SKIP	0,4	Paf1	24,28	SKIP	Paf1	844055(Tax:3702)	834290(Tax:3702)	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	SKIP Interacts with the Paf1 Complex to Regulate Flowering via the Activation of FLC Transcription in Arabidopsis .
22751929	0	SKIP	91,95	Pak1	132,136	SKIP	Pak1	51763	5058	Gene	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	Regulation of insulin signaling by the phosphatidylinositol_3 ,4,5 - triphosphate phosphatase SKIP through the scaffolding function of Pak1 .
16595688	0	SKIP	108,112	peptidyl_prolyl_isomerase-like_protein_1	28,68	SKIP	peptidyl prolyl isomerase-like protein 1	22938	51645	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Solution structure of human peptidyl_prolyl_isomerase-like_protein_1 and insights into its interaction with SKIP .
9305750	0	SKK4	0,4	stress-activated_protein_kinase-1	27,60	SKK4	stress-activated protein kinase-1	5609	5599	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	SKK4 , a novel activator of stress-activated_protein_kinase-1 -LRB- SAPK1/JNK -RRB- .
26031529	0	SKM-1	30,35	hENT1	21,26	SKM-1	hENT1	6329	2030	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	-LSB- Functional study of hENT1 on SKM-1 cell resistance to decitabine -RSB- .
8383257	0	SKM-1	117,122	myeloperoxidase	60,75	SKM-1	myeloperoxidase	6329	4353	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic_leukemia cell line , SKM-1 .
22733130	0	SKP-2	23,28	PI3K	0,4	SKP-2	PI3K	6502	5293	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	PI3K regulation of the SKP-2 / p27 axis through mTORC2 .
16897472	0	SKP1	8,12	ASK1	0,4	SKP1	ASK1	843928(Tax:3702)	843928(Tax:3702)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	ASK1 , a SKP1 homolog , is required for nuclear reorganization , presynaptic homolog juxtaposition and the proper distribution of cohesin during meiosis in Arabidopsis .
9663463	0	SKP1	77,81	CUL-1	6,11	SKP1	CUL-1	6500	8454	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human CUL-1 , but not other cullin family members , selectively interacts with SKP1 to form a complex with SKP2 and cyclin_A .
18008005	0	SKP2	74,78	FOXP3	0,5	SKP2	FOXP3	6502	50943	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	FOXP3 is a novel transcriptional repressor for the breast_cancer oncogene SKP2 .
11250155	0	SKP2	118,122	KIP1	76,80	SKP2	KIP1	6502	1027	Gene	Gene	SCF|appos|START_ENTITY regulates|nmod|SCF regulates|dobj|degradation degradation|nmod|p27 p27|appos|END_ENTITY	PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27 -LRB- KIP1 -RRB- through the ubiquitin E3 ligase SCF -LRB- SKP2 -RRB- .
12586749	0	SKP2	32,36	KIP1	108,112	SKP2	KIP1	6502	1027	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Inhibition of F-Box protein p45 -LRB- SKP2 -RRB- expression and stabilization of cyclin-dependent kinase inhibitor p27 -LRB- KIP1 -RRB- in vitamin_D analog-treated cancer cells .
16988944	0	SKP2	68,72	KIP1	45,49	SKP2	KIP1	6502	1027	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|p27 p27|appos|END_ENTITY	Downregulation of the KIP family members p27 -LRB- KIP1 -RRB- and p57 -LRB- KIP2 -RRB- by SKP2 and the role of methylation in p57 -LRB- KIP2 -RRB- inactivation in nonsmall_cell_lung_cancer .
17438373	0	SKP2	18,22	KIP1	61,65	SKP2	KIP1	6502	1027	Gene	Gene	ubiquitin|appos|START_ENTITY Regulation|nmod|ubiquitin E3|nsubj|Regulation E3|ccomp|proteolysis proteolysis|nsubj|assembly assembly|appos|END_ENTITY	Regulation of SCF -LRB- SKP2 -RRB- ubiquitin E3 ligase assembly and p27 -LRB- KIP1 -RRB- proteolysis by the PTEN pathway and cyclin_D1 .
21245140	0	SKP2	83,87	KIP1	69,73	SKP2	KIP1	6502	1027	Gene	Gene	MYC|nmod|START_ENTITY MYC|dobj|p27 p27|appos|END_ENTITY	SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27 -LRB- KIP1 -RRB- through SKP2 in human leukemia cells .
22372491	0	SKP2	27,31	KIP1	46,50	SKP2	KIP1	6502	1027	Gene	Gene	START_ENTITY|xcomp|induce induce|dobj|stabilization stabilization|appos|END_ENTITY	Prodigiosin down-regulates SKP2 to induce p27 -LRB- KIP1 -RRB- stabilization and antiproliferation in human lung_adenocarcinoma cells .
25070589	0	SKP2	28,32	KIP1	50,54	SKP2	KIP1	6502	1027	Gene	Gene	START_ENTITY|xcomp|stabilize stabilize|dobj|p27 p27|appos|END_ENTITY	Sulforaphane down-regulates SKP2 to stabilize p27 -LRB- KIP1 -RRB- for inducing antiproliferation in human colon_adenocarcinoma cells .
16988944	0	SKP2	68,72	KIP2	59,63	SKP2	KIP2	6502	1028	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|p27 p27|appos|END_ENTITY	Downregulation of the KIP family members p27 -LRB- KIP1 -RRB- and p57 -LRB- KIP2 -RRB- by SKP2 and the role of methylation in p57 -LRB- KIP2 -RRB- inactivation in nonsmall_cell_lung_cancer .
24986570	0	SKP2	102,106	MMP-2	18,23	SKP2	MMP-2	6502	4313	Gene	Gene	renal_cell_carcinoma|nmod|START_ENTITY invasion|nmod|renal_cell_carcinoma signaling|nsubj|invasion promote|dep|signaling promote|nsubj|Imbalance Imbalance|nmod|END_ENTITY	Imbalance between MMP-2 , 9 and TIMP-1 promote the invasion and metastasis of renal_cell_carcinoma via SKP2 signaling pathways .
23226679	0	SKP2	5,9	MYCN	23,27	SKP2	MYCN	6502	4613	Gene	Gene	p53|nummod|START_ENTITY p53|nmod|Genes Genes|compound|END_ENTITY	p53 , SKP2 , and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance .
25843293	0	SKP2	0,4	MYCN	43,47	SKP2	MYCN	6502	4613	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma .
25537506	0	SKP2	0,4	N-Ras	21,26	SKP2	N-Ras	27401(Tax:10090)	18176(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	SKP2 cooperates with N-Ras or AKT to induce liver_tumor development in mice .
19657571	0	SKP2	0,4	P27kip1	39,46	SKP2	P27kip1	6502	1027	Gene	Gene	siRNA|compound|START_ENTITY inhibits|nsubj|siRNA inhibits|dobj|degradation degradation|nmod|END_ENTITY	SKP2 siRNA inhibits the degradation of P27kip1 and down-regulates the expression of MRP in HL-60 / A cells .
15700547	0	SKP2	52,56	S-phase_kinase-associated_protein_2	15,50	SKP2	S-phase kinase-associated protein 2	6502	6502	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of S-phase_kinase-associated_protein_2 -LRB- SKP2 -RRB- on cell cycle status , viability , and chemoresistance in A549 lung_adenocarcinoma cells .
19174556	0	SKP2	41,45	WIF1	0,4	SKP2	WIF1	6502	11197	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	WIF1 , a Wnt pathway inhibitor , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder_cancer cells .
11689688	0	SKP2	38,42	cyclin_T1	20,29	SKP2	cyclin T1	6502	904	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between cyclin_T1 and SCF -LRB- SKP2 -RRB- targets CDK9 for ubiquitination and degradation by the proteasome .
12717421	0	SKP2	0,4	p130	21,25	SKP2	p130	6502	5934	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells .
10559916	0	SKP2	0,4	p27	73,76	SKP2	p27	6502	10671	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|degradation degradation|nmod|END_ENTITY	SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 .
11250155	0	SKP2	118,122	p27	72,75	SKP2	p27	6502	10671	Gene	Gene	SCF|appos|START_ENTITY regulates|nmod|SCF regulates|dobj|degradation degradation|nmod|END_ENTITY	PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27 -LRB- KIP1 -RRB- through the ubiquitin E3 ligase SCF -LRB- SKP2 -RRB- .
12188931	0	SKP2	18,22	p27	52,55	SKP2	p27	6502	10671	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|control control|nmod|stability stability|amod|END_ENTITY	The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate_cancer cells .
16988944	0	SKP2	68,72	p27	41,44	SKP2	p27	6502	10671	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of the KIP family members p27 -LRB- KIP1 -RRB- and p57 -LRB- KIP2 -RRB- by SKP2 and the role of methylation in p57 -LRB- KIP2 -RRB- inactivation in nonsmall_cell_lung_cancer .
21245140	0	SKP2	83,87	p27	65,68	SKP2	p27	6502	10671	Gene	Gene	MYC|nmod|START_ENTITY MYC|dobj|END_ENTITY	SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27 -LRB- KIP1 -RRB- through SKP2 in human leukemia cells .
21503567	0	SKP2	68,72	p27	28,31	SKP2	p27	6502	10534	Gene	Gene	direct|nmod|START_ENTITY degradation|nmod|direct degradation|amod|END_ENTITY	Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian_and_breast_cancer .
22372491	0	SKP2	27,31	p27	42,45	SKP2	p27	6502	10671	Gene	Gene	START_ENTITY|xcomp|induce induce|dobj|stabilization stabilization|amod|END_ENTITY	Prodigiosin down-regulates SKP2 to induce p27 -LRB- KIP1 -RRB- stabilization and antiproliferation in human lung_adenocarcinoma cells .
24443386	0	SKP2	0,4	p27	78,81	SKP2	p27	6502	3429	Gene	Gene	overexpression|compound|START_ENTITY associated|nsubjpass|overexpression associated|nmod|phosphorylation phosphorylation|nmod|pSer10p27 pSer10p27|amod|END_ENTITY	SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 -LRB- pSer10p27 -RRB- in triple-negative breast_cancer .
25070589	0	SKP2	28,32	p27	46,49	SKP2	p27	6502	10671	Gene	Gene	START_ENTITY|xcomp|stabilize stabilize|dobj|END_ENTITY	Sulforaphane down-regulates SKP2 to stabilize p27 -LRB- KIP1 -RRB- for inducing antiproliferation in human colon_adenocarcinoma cells .
15980415	0	SKP2	108,112	p27Kip1	18,25	SKP2	p27Kip1	6502	1027	Gene	Gene	E|nmod|START_ENTITY requires|nmod|E requires|nsubj|Ubiquitination Ubiquitination|nmod|END_ENTITY	Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2 .
12586749	0	SKP2	32,36	p45	28,31	SKP2	p45	6502	6502	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of F-Box protein p45 -LRB- SKP2 -RRB- expression and stabilization of cyclin-dependent kinase inhibitor p27 -LRB- KIP1 -RRB- in vitamin_D analog-treated cancer cells .
18718460	0	SKR-1	0,5	Skp1	20,24	SKR-1	Skp1	172775(Tax:6239)	179598(Tax:6239)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	SKR-1 , a homolog of Skp1 and a member of the SCF -LRB- SEL-10 -RRB- complex , regulates sex-determination and LIN-12 / Notch signaling in C. _ elegans .
19338451	0	SKT	41,44	KIAA1217	51,59	SKT	KIAA1217	56243	56243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the tag SNPs in the human SKT gene -LRB- KIAA1217 -RRB- with lumbar_disc_herniation .
11849592	0	SKT1	15,19	KST1	41,45	SKT1	KST1	102581965	102583546	Gene	Gene	co-expressed|nsubjpass|START_ENTITY co-expressed|nmod|END_ENTITY	The K + channel SKT1 is co-expressed with KST1 in potato guard cells -- both channels can co-assemble via their conserved KT domains .
10894955	0	SL1	166,169	TAF1A	40,45	SL1	TAF1A	9013	9015	Gene	Gene	localization|nmod|START_ENTITY localization|amod|END_ENTITY	Genomic localization of the human genes TAF1A , TAF1B and TAF1C , encoding TAF -LRB- I -RRB- 48 , TAF -LRB- I -RRB- 63 and TAF -LRB- I -RRB- 110 subunits of class I general transcription initiation factor SL1 .
8609157	0	SL1	43,46	UBF	64,67	SL1	UBF	9014	7343	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	In vivo evidence that TATA-binding_protein / SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive .
8825655	0	SLA	106,109	Src-like_adapter_protein	38,62	SLA	Src-like adapter protein	6503	20491(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|gene gene|compound|END_ENTITY	Chromosomal localization of the mouse Src-like_adapter_protein -LRB- Slap -RRB- gene and its putative human homolog SLA .
20933013	0	SLAM	14,18	CD150	20,25	SLAM	CD150	6504	6504	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of SLAM -LRB- CD150 -RRB- cell-surface receptors on human B-cell subsets : from pro-B to plasma cells .
11160657	0	SLAM	18,22	CDw150	24,30	SLAM	CDw150	6504	6504	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	V domain of human SLAM -LRB- CDw150 -RRB- is essential for its function as a measles_virus receptor .
23731618	0	SLAM	7,11	CS1	0,3	SLAM	CS1	6504	57823	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	CS1 , a SLAM family receptor involved in immune regulation , is a therapeutic target in multiple_myeloma .
20146065	0	SLAM	0,4	SAP	55,58	SLAM	SAP	6504	4068	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	SLAM family receptors and the SLAM-associated_protein -LRB- SAP -RRB- modulate T cell functions .
10479532	0	SLAM	51,55	signaling_lymphocytic_activation_molecule	8,49	SLAM	signaling lymphocytic activation molecule	6504	6504	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Altered signaling_lymphocytic_activation_molecule -LRB- SLAM -RRB- expression in HIV_infection and redirection of HIV-specific responses via SLAM triggering .
15560546	0	SLAM-associated_protein	5,28	IFN-gamma	45,54	SLAM-associated protein	IFN-gamma	4068	3458	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	-LSB- The SLAM-associated_protein -LRB- SAP -RRB- regulates IFN-gamma expression in leprosy -RSB- .
16223723	0	SLAM-associated_protein	0,23	Trk	61,64	SLAM-associated protein	Trk	29339(Tax:10116)	59109(Tax:10116)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	SLAM-associated_protein as a potential negative regulator in Trk signaling .
11099315	0	SLAM_and_2B4	148,160	SAP	126,129	SLAM and 2B4	SAP	6504;51744	4068	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Potential pathways for regulation of NK and T cell responses : differential X-linked_lymphoproliferative_syndrome gene product SAP interactions with SLAM_and_2B4 .
19738428	0	SLAM_associated_protein	38,61	SAP	33,36	SLAM associated protein	SAP	4068	4068	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The apoptosis modulating role of SAP -LRB- SLAM_associated_protein -RRB- contributes to the symptomatology of the X_linked_lymphoproliferative_disease .
25772501	0	SLAP	34,38	SRC-like_adaptor_protein	8,32	SLAP	SRC-like adaptor protein	6503	6503	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of SRC-like_adaptor_protein -LRB- SLAP -RRB- in immune and malignant cell signaling .
10640723	0	SLAP-130	39,47	FYB	48,51	SLAP-130	FYB	2533	2533	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Cutting edge : a novel function for the SLAP-130 / FYB adapter protein in beta_1_integrin signaling and T lymphocyte migration .
20828795	0	SLAP-2	82,88	Src-like_adaptor_protein_2	9,35	SLAP-2	Src-like adaptor protein 2	84174	84174	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of Src-like_adaptor_protein_2 -LRB- SLAP-2 -RRB- in GPVI-mediated platelet activation SLAP-2 and GPVI signaling .
16623714	0	SLAP-2	50,56	colony_stimulating_factor-1_receptor	77,113	SLAP-2	colony stimulating factor-1 receptor	77799(Tax:10090)	12978(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	A potential role for the Src-like_adapter_protein SLAP-2 in signaling by the colony_stimulating_factor-1_receptor .
26483383	0	SLAT	0,4	Rap1	115,119	SLAT	Rap1	50619	5906	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	SLAT promotes TCR-mediated , Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1 .
23286197	0	SLBP	105,109	SLIP1	122,127	SLBP	SLIP1	7884	57409	Gene	Gene	START_ENTITY|acl|followed followed|nmod|END_ENTITY	Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1 .
11278733	0	SLC-1	106,111	MCH	123,126	SLC-1	MCH	2847	5367	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Structure-activity relationship studies of melanin-concentrating_hormone -LRB- MCH -RRB- - related peptide ligands at SLC-1 , the human MCH receptor .
27033324	0	SLC10A6	117,124	SOAT	111,115	SLC10A6	SOAT	345274	345274	Gene	Gene	Identification|appos|START_ENTITY Identification|nmod|inhibitors inhibitors|nmod|END_ENTITY	Identification of novel inhibitors of the steroid_sulfate carrier ` sodium-dependent_organic_anion_transporter ' SOAT -LRB- SLC10A6 -RRB- by pharmacophore modelling .
12358853	0	SLC11A1	32,39	NRAMP1	24,30	SLC11A1	NRAMP1	100033912(Tax:9796)	100033912(Tax:9796)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the NRAMP1 -LRB- SLC11A1 -RRB- gene in the horse -LRB- Equus_caballus L. -RRB- .
12552460	0	SLC11A1	16,23	NRAMP1	34,40	SLC11A1	NRAMP1	6556	6556	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of SLC11A1 -LRB- formerly NRAMP1 -RRB- gene confers susceptibility to Kawasaki_disease .
18998137	0	SLC11A1	72,79	NRAMP1	64,70	SLC11A1	NRAMP1	6556	6556	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Genetic susceptibility to Beh __ et 's _ syndrome is associated with NRAMP1 -LRB- SLC11A1 -RRB- polymorphism in Turkish patients .
17378896	0	SLC11A1	53,60	solute_carrier_family_11_member_1	10,43	SLC11A1	solute carrier family 11 member 1	6556	6556	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The human solute_carrier_family_11_member_1 protein -LRB- SLC11A1 -RRB- : linking infections , autoimmunity and cancer ?
20338449	0	SLC11A1	99,106	solute_carrier_family_11_member_1	64,97	SLC11A1	solute carrier family 11 member 1	282470(Tax:9913)	282470(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of single nucleotide polymorphisms in the bovine solute_carrier_family_11_member_1 -LRB- SLC11A1 -RRB- gene and their association with infection by Mycobacterium_avium subspecies paratuberculosis .
16091455	0	SLC11A2	43,50	DMT1	37,41	SLC11A2	DMT1	4891	4891	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Functional consequences of the human DMT1 -LRB- SLC11A2 -RRB- mutation on protein expression and iron uptake .
21276595	0	SLC11A2	62,69	divalent_metal_transport_1	20,46	SLC11A2	divalent metal transport 1	4891	4891	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between divalent_metal_transport_1 encoding gene -LRB- SLC11A2 -RRB- and disease duration in amyotrophic_lateral_sclerosis .
12091367	0	SLC11A3	119,126	ferroportin_1	99,112	SLC11A3	ferroportin 1	30061	30061	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin_1 gene -LRB- SLC11A3 -RRB- .
11325574	0	SLC12A6	64,71	KCC3	58,62	SLC12A6	KCC3	9990	9990	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Mutation analysis of the potassium_chloride cotransporter KCC3 -LRB- SLC12A6 -RRB- in rolandic and idiopathic_generalized_epilepsy .
21873665	0	SLC13A3	103,110	PITX2	0,5	SLC13A3	PITX2	64849	5308	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	PITX2 is involved in stress response in cultured human trabecular meshwork cells through regulation of SLC13A3 .
15607730	0	SLC13A4	106,113	hNaS2	94,99	SLC13A4	hNaS2	26266	26266	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional characterization and genomic organization of the human Na -LRB- + -RRB- - sulfate cotransporter hNaS2 gene -LRB- SLC13A4 -RRB- .
25628225	0	SLC13A5	0,7	Pregnane_X_Receptor	49,68	SLC13A5	Pregnane X Receptor	284111	8856	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	SLC13A5 Is a Novel Transcriptional Target of the Pregnane_X_Receptor and Sensitizes Drug-Induced Steatosis in Human Liver .
17498647	0	SLC15A1	33,40	hPepT1	25,31	SLC15A1	hPepT1	6564	6564	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regulation of intestinal hPepT1 -LRB- SLC15A1 -RRB- activity by phosphodiesterase inhibitors is via inhibition of NHE3 -LRB- SLC9A3 -RRB- .
19881260	0	SLC16A1	32,39	MCT1	26,30	SLC16A1	MCT1	6566	6566	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variations in the MCT1 -LRB- SLC16A1 -RRB- gene in the Chinese population of Singapore .
18636565	0	SLC16A2	66,73	MCT8	60,64	SLC16A2	MCT8	6567	6567	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 -LRB- SLC16A2 -RRB- mutations .
18710470	0	SLC16A2	111,118	monocarboxylate_transporter_8	80,109	SLC16A2	monocarboxylate transporter 8	6567	6567	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Prevalence and functional analysis of the S107P polymorphism -LRB- rs6647476 -RRB- of the monocarboxylate_transporter_8 -LRB- SLC16A2 -RRB- gene in the male population of north-west Spain -LRB- Galicia -RRB- .
22240841	0	SLC16A3	32,39	MCT4	26,30	SLC16A3	MCT4	9123	9123	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic variations of the MCT4 -LRB- SLC16A3 -RRB- gene in the Chinese and Indian populations of Singapore .
26035357	0	SLC16A7	39,46	MCT2	48,52	SLC16A7	MCT2	9194	9194	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Epigenetic and oncogenic regulation of SLC16A7 -LRB- MCT2 -RRB- results in protein over-expression , impacting on signalling and cellular phenotypes in prostate_cancer .
15950021	0	SLC1A3	66,72	solute_carrier_family_1-member_3	32,64	SLC1A3	solute carrier family 1-member 3	6507	6507	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A family based study implicates solute_carrier_family_1-member_3 -LRB- SLC1A3 -RRB- gene in attention-deficit/hyperactivity _ disorder .
15499200	0	SLC22A1	57,64	organic_cation_transporter_1	79,107	SLC22A1	organic cation transporter 1	6580	6580	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic_cation_transporter_1 -LRB- OCT1 -RRB- .
16837472	0	SLC22A12	26,34	URAT1	36,41	SLC22A12	URAT1	116085	116085	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the SLC22A12 -LRB- URAT1 -RRB- gene in patients with primary_gout .
21523786	0	SLC22A2	59,66	OCT2	68,72	SLC22A2	OCT2	6582	6582	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interindividual differences in placental expression of the SLC22A2 -LRB- OCT2 -RRB- gene : relationship to epigenetic variations in the 5 ' - upstream regulatory region .
18710896	0	SLC22A3	46,53	organic_cation_transporter_3	16,44	SLC22A3	organic cation transporter 3	6581	100049579	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Significance of organic_cation_transporter_3 -LRB- SLC22A3 -RRB- expression for the cytotoxic effect of oxaliplatin in colorectal_cancer .
22342816	0	SLC22A3	44,51	organic_cation_transporter_3	14,42	SLC22A3	organic cation transporter 3	6581	100049579	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of organic_cation_transporter_3 -LRB- SLC22A3 -RRB- inhibition as a potential mechanism of antidepressant action .
15832501	0	SLC22A4	22,29	OCTN1	15,20	SLC22A4	OCTN1	6583	6583	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of OCTN1 -LRB- SLC22A4 -RRB- in pH-dependent transport of organic cations .
14608356	0	SLC22A4	43,50	RUNX1	21,26	SLC22A4	RUNX1	30805(Tax:10090)	12394(Tax:10090)	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	An intronic SNP in a RUNX1 binding site of SLC22A4 , encoding an organic cation transporter , is associated with rheumatoid_arthritis .
26370461	0	SLC22A5	44,51	OCTN2	37,42	SLC22A5	OCTN2	6584	6584	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Organic cation/carnitine transporter OCTN2 -LRB- SLC22A5 -RRB- -207 C > G -LRB- rs2631367 -RRB- polymorphism is not associated with male_infertility .
18520060	0	SLC22A5	33,40	peroxisome_proliferator_activated_receptor_alpha	45,93	SLC22A5	peroxisome proliferator activated receptor alpha	29726(Tax:10116)	25747(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Octn2 transporter -LRB- SLC22A5 -RRB- by peroxisome_proliferator_activated_receptor_alpha .
15901346	0	SLC22A7	91,98	hOat2	84,89	SLC22A7	hOat2	10864	10864	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Transport mechanism and substrate specificity of human organic_anion_transporter_2 -LRB- hOat2 -LSB- SLC22A7 -RSB- -RRB- .
15901346	0	SLC22A7	91,98	organic_anion_transporter_2	55,82	SLC22A7	organic anion transporter 2	10864	10864	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	Transport mechanism and substrate specificity of human organic_anion_transporter_2 -LRB- hOat2 -LSB- SLC22A7 -RSB- -RRB- .
16247710	0	SLC22A8	44,51	OAT3	38,42	SLC22A8	OAT3	9376	9376	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Pharmacokinetic significance of renal OAT3 -LRB- SLC22A8 -RRB- for anionic drug elimination in patients with mesangial_proliferative_glomerulonephritis .
23615001	0	SLC22A8	49,56	organic_anion_transporter_3	20,47	SLC22A8	organic anion transporter 3	9376	9376	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of renal organic_anion_transporter_3 -LRB- SLC22A8 -RRB- expression and function by the integrity of lipid raft domains and their associated cytoskeleton .
26170735	0	SLC22A9	17,24	hOAT7	26,31	SLC22A9	hOAT7	114571	114571	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms of SLC22A9 -LRB- hOAT7 -RRB- in Korean Females with Osteoporosis .
26239079	0	SLC22A9	65,72	organic_anion_transporter_7	37,64	SLC22A9	organic anion transporter 7	114571	114571	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Variability in hepatic expression of organic_anion_transporter_7 / SLC22A9 , a novel pravastatin uptake transporter : impact of genetic and regulatory factors .
25072865	0	SLC25A1	49,56	TNFa	61,65	SLC25A1	TNFa	6576	7124	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A key role of the mitochondrial citrate carrier -LRB- SLC25A1 -RRB- in TNFa - and IFNy-triggered inflammation .
24681808	0	SLC25A1	0,7	p53	61,64	SLC25A1	p53	6576	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	SLC25A1 , or CIC , is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker .
17693006	0	SLC25A12	84,92	aralar	94,100	SLC25A12	aralar	8604	8604	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 -LRB- aralar -RRB- gene with schizophrenia .
19908284	0	SLC25A13	22,30	citrin	14,20	SLC25A13	citrin	50799(Tax:10090)	50799(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Low levels of citrin -LRB- SLC25A13 -RRB- expression in adult mouse brain restricted to neuronal_clusters .
16919490	0	SLC25A20	8,16	carnitine-acylcarnitine_translocase	97,132	SLC25A20	carnitine-acylcarnitine translocase	788	788	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	A novel SLC25A20 splicing mutation in patients of different ethnic origin with neonatally lethal carnitine-acylcarnitine_translocase -LRB- CACT -RRB- deficiency .
19748481	0	SLC25A20	24,32	peroxisome_proliferator-activated_receptor_alpha	47,95	SLC25A20	peroxisome proliferator-activated receptor alpha	788	5465	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of the human SLC25A20 expression by peroxisome_proliferator-activated_receptor_alpha in human hepatoblastoma cells .
23151810	0	SLC26A11	47,55	RNF213	38,44	SLC26A11	RNF213	284129	57674	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel gene fusion RNF213 - SLC26A11 in chronic myeloid_leukemia by RNA-Seq .
11241838	0	SLC26A2	73,80	DTDST	60,65	SLC26A2	DTDST	1836	1836	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Mutations in the diastrophic_dysplasia sulfate transporter -LRB- DTDST -RRB- gene -LRB- SLC26A2 -RRB- : 22 novel mutations , mutation review , associated skeletal phenotypes , and diagnostic relevance .
20369363	0	SLC26A2	24,31	DTDST	33,38	SLC26A2	DTDST	117267(Tax:10116)	117267(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Protein localization of SLC26A2 -LRB- DTDST -RRB- in rat kidney .
20592910	0	SLC26A2	129,136	DTDST	122,127	SLC26A2	DTDST	1836	1836	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Autosomal recessive multiple_epiphyseal_dysplasia in a Korean girl caused by novel compound heterozygous mutations in the DTDST -LRB- SLC26A2 -RRB- gene .
26700142	0	SLC26A3	41,48	AMP18	0,5	SLC26A3	AMP18	1811	56287	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	AMP18 interacts with the anion exchanger SLC26A3 and enhances its expression in gastric_cancer cells .
25887398	0	SLC26A3	34,41	DRA	43,46	SLC26A3	DRA	1811	1811	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	All-Trans-Retinoic_Acid Increases SLC26A3 -LRB- DRA -RRB- Expression In Intestinal Epithelial Cells Via HNF-1b .
24177028	0	SLC26A3	28,35	miR-494	39,46	SLC26A3	miR-494	1811	574452	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Translational repression of SLC26A3 by miR-494 in intestinal epithelial cells .
14508505	0	SLC26A4	37,44	PDS	32,35	SLC26A4	PDS	5172	5172	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Distribution and frequencies of PDS -LRB- SLC26A4 -RRB- mutations in Pendred_syndrome and nonsyndromic_hearing_loss associated with enlarged_vestibular_aqueduct : a unique spectrum of mutations in Japanese .
15203903	0	SLC26A6	41,48	PAT1	35,39	SLC26A6	PAT1	65010	206358	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of anion exchange transporter PAT1 -LRB- SLC26A6 -RRB- in intestinal absorption of organic anions .
20658517	0	SLC26A9	0,7	CFTR	19,23	SLC26A9	CFTR	115019	1080	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	SLC26A9 stimulates CFTR expression and function in human bronchial cell lines .
17065791	0	SLC27A1	92,99	solute_carrier_family_27_member_1	57,90	SLC27A1	solute carrier family 27 member 1	513787(Tax:9913)	513787(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural and functional characterization of the bovine solute_carrier_family_27_member_1 -LRB- SLC27A1 -RRB- gene .
16688763	0	SLC29A1	54,61	ENT1	43,47	SLC29A1	ENT1	2030	2030	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Nitric_oxide reduces adenosine transporter ENT1 gene -LRB- SLC29A1 -RRB- promoter activity in human fetal endothelium from gestational diabetes .
25802735	0	SLC29A4	83,90	PMAT	130,134	SLC29A4	PMAT	222962	222962	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Autism_spectrum_disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma_membrane_monoamine_transporter -LRB- PMAT -RRB- gene .
25802735	0	SLC29A4	83,90	plasma_membrane_monoamine_transporter	91,128	SLC29A4	plasma membrane monoamine transporter	222962	222962	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Autism_spectrum_disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma_membrane_monoamine_transporter -LRB- PMAT -RRB- gene .
10980529	0	SLC2A1	30,36	GLUT1	23,28	SLC2A1	GLUT1	6513	6513	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Mutational analysis of GLUT1 -LRB- SLC2A1 -RRB- in Glut-1 deficiency_syndrome .
11102982	0	SLC2A1	30,36	GLUT1	23,28	SLC2A1	GLUT1	6513	6513	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Mutational analysis of GLUT1 -LRB- SLC2A1 -RRB- in glut-1 deficiency syndrome ; dong wang ; pamela kranz-eble ; darryl_C .
17489814	0	SLC2A1	54,60	GLUT1	62,67	SLC2A1	GLUT1	6513	6513	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel microdeletion in 1 -LRB- p34 .2 p34 .3 -RRB- , involving the SLC2A1 -LRB- GLUT1 -RRB- gene , and severe delayed development .
20540786	0	SLC2A1	108,114	HIF1A	143,148	SLC2A1	HIF1A	6513	3091	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The association of 18F-deoxyglucose -LRB- FDG -RRB- uptake of PET with polymorphisms in the glucose transporter gene -LRB- SLC2A1 -RRB- and hypoxia-related genes -LRB- HIF1A , VEGFA , APEX1 -RRB- in non-small_cell_lung_cancer .
15936967	0	SLC2A10	14,21	GLUT10	23,29	SLC2A10	GLUT10	81031	81031	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of SLC2A10 -LRB- GLUT10 -RRB- as a candidate gene for type_2_diabetes and related traits in Finns .
16154905	0	SLC2A11	30,37	GLUT11	39,45	SLC2A11	GLUT11	66035	66035	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the human SLC2A11 -LRB- GLUT11 -RRB- gene : alternative promoter usage , function , expression , and subcellular distribution of three isoforms , and lack of mouse orthologue .
12700970	0	SLC2A2	19,25	GLUT2	28,33	SLC2A2	GLUT2	6514	6514	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No mutation in the SLC2A2 -LRB- GLUT2 -RRB- gene in a Turkish infant with Fanconi-Bickel_syndrome .
15983230	0	SLC2A2	21,27	GLUT2	29,34	SLC2A2	GLUT2	6514	6514	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the SLC2A2 -LRB- GLUT2 -RRB- gene are associated with the conversion from impaired_glucose_tolerance to type 2 diabetes : the Finnish Diabetes Prevention Study .
19433262	0	SLC2A2	0,6	HNF-1alpha	66,76	SLC2A2	HNF-1alpha	25351(Tax:10116)	24817(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta .
17019595	0	SLC2A4	75,81	GLUT4	68,73	SLC2A4	GLUT4	6517	6517	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Exercise training increases insulin-stimulated glucose disposal and GLUT4 -LRB- SLC2A4 -RRB- protein content in patients with type 2 diabetes .
24858040	0	SLC2A9	26,32	p53	81,84	SLC2A9	p53	56606	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	The uric_acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense .
24194756	0	SLC30A2	105,112	ZnT-2	98,103	SLC30A2	ZnT-2	7780	7780	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Transient Neonatal_Zinc_Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 -LRB- SLC30A2 -RRB- Gene in the Mother Highlighting the Importance of Zn _ -LRB- 2 + -RRB- for Normal Growth and Development .
18162508	0	SLC30A8	48,55	CDKAL1	15,21	SLC30A8	CDKAL1	169026	54901	Gene	Gene	HHEX|nummod|START_ENTITY HHEX|nummod|END_ENTITY	Association of CDKAL1 , IGF2BP2 , CDKN2A/B , HHEX , SLC30A8 , and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population .
18469204	0	SLC30A8	45,52	CDKAL1	60,66	SLC30A8	CDKAL1	169026	54901	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
19008344	0	SLC30A8	55,62	CDKAL1	47,53	SLC30A8	CDKAL1	169026	54901	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	SLC30A8	37,44	CDKAL1	52,58	SLC30A8	CDKAL1	169026	54901	Gene	Gene	KCNQ1|compound|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
22487833	0	SLC30A8	66,73	CDKAL1	58,64	SLC30A8	CDKAL1	169026	54901	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
20424228	0	SLC30A8	52,59	CDKN2A	67,73	SLC30A8	CDKN2A	169026	1029	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
18469204	0	SLC30A8	45,52	CDKN2A/B	68,76	SLC30A8	CDKN2A/B	169026	1029;1030	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20509872	0	SLC30A8	37,44	CDKN2A/B	60,68	SLC30A8	CDKN2A/B	169026	1029;1030	Gene	Gene	KCNQ1|compound|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
19008344	0	SLC30A8	55,62	EXT2	70,74	SLC30A8	EXT2	169026	2132	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
19008344	0	SLC30A8	55,62	FTO	42,45	SLC30A8	FTO	169026	79068	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|compound|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	SLC30A8	37,44	FTO	79,82	SLC30A8	FTO	169026	79068	Gene	Gene	KCNQ1|compound|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	SLC30A8	45,52	HHEX	54,58	SLC30A8	HHEX	169026	3087	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
19008344	0	SLC30A8	55,62	HHEX	64,68	SLC30A8	HHEX	169026	3087	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20424228	0	SLC30A8	52,59	HHEX	61,65	SLC30A8	HHEX	169026	3087	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20509872	0	SLC30A8	37,44	HHEX	46,50	SLC30A8	HHEX	169026	3087	Gene	Gene	KCNQ1|compound|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
22487833	0	SLC30A8	66,73	HHEX	75,79	SLC30A8	HHEX	169026	3087	Gene	Gene	genes|nummod|START_ENTITY genes|dep|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
19008344	0	SLC30A8	55,62	IGF2BP2	76,83	SLC30A8	IGF2BP2	169026	10644	Gene	Gene	LOC387761|appos|START_ENTITY LOC387761|appos|END_ENTITY	Association analysis of variation in/near FTO , CDKAL1 , SLC30A8 , HHEX , EXT2 , IGF2BP2 , LOC387761 , and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians .
20509872	0	SLC30A8	37,44	IGF2BP2	70,77	SLC30A8	IGF2BP2	169026	10644	Gene	Gene	KCNQ1|compound|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20424228	0	SLC30A8	52,59	KCNJ11	36,42	SLC30A8	KCNJ11	169026	3767	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20424228	0	SLC30A8	52,59	PPARG	29,34	SLC30A8	PPARG	169026	5468	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20509872	0	SLC30A8	37,44	TCF2	84,88	SLC30A8	TCF2	169026	6928	Gene	Gene	KCNQ1|compound|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
18469204	0	SLC30A8	45,52	TCF7L2	37,43	SLC30A8	TCF7L2	169026	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20424228	0	SLC30A8	52,59	TCF7L2	44,50	SLC30A8	TCF7L2	169026	6934	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
22487833	0	SLC30A8	66,73	TCF7L2	50,56	SLC30A8	TCF7L2	169026	6934	Gene	Gene	genes|nummod|START_ENTITY genes|compound|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
18628523	0	SLC30A8	25,32	Zinc_transporter-8	0,18	SLC30A8	Zinc transporter-8	169026	55532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Zinc_transporter-8 gene -LRB- SLC30A8 -RRB- is associated with type 2 diabetes in Chinese .
24306209	0	SLC30A8	46,53	zinc_transporter-8	21,39	SLC30A8	zinc transporter-8	169026	55532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interactions between zinc_transporter-8 gene -LRB- SLC30A8 -RRB- and plasma zinc concentrations for impaired_glucose_regulation and type_2_diabetes .
20461110	0	SLC33A1	99,106	SPG42	113,118	SLC33A1	SPG42	9197	9197	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A total of 220 patients with autosomal_dominant_spastic_paraplegia do not display mutations in the SLC33A1 gene -LRB- SPG42 -RRB- .
26506223	0	SLC34A2	60,67	NaPi-IIb	50,58	SLC34A2	NaPi-IIb	20531(Tax:10090)	432056(Tax:8355)	Gene	Gene	Up-Regulation|appos|START_ENTITY Up-Regulation|nmod|END_ENTITY	Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb -LRB- SLC34A2 -RRB- by the Kinases SPAK and OSR1 .
26506223	0	SLC34A2	60,67	SPAK	84,88	SLC34A2	SPAK	20531(Tax:10090)	53416(Tax:10090)	Gene	Gene	Up-Regulation|appos|START_ENTITY Up-Regulation|nmod|END_ENTITY	Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb -LRB- SLC34A2 -RRB- by the Kinases SPAK and OSR1 .
21511949	0	SLC38A7	18,25	SNAT7	27,32	SLC38A7	SNAT7	55238	55238	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of SLC38A7 -LRB- SNAT7 -RRB- protein as a glutamine transporter expressed in neurons .
26133979	0	SLC39A5	36,43	ZIP5	30,34	SLC39A5	ZIP5	283375	283375	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Knockdown of zinc transporter ZIP5 -LRB- SLC39A5 -RRB- expression significantly inhibits human esophageal_cancer progression .
26133979	0	SLC39A5	36,43	ZIP5	30,34	SLC39A5	ZIP5	283375	283375	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Knockdown of zinc transporter ZIP5 -LRB- SLC39A5 -RRB- expression significantly inhibits human esophageal_cancer progression .
26623077	0	SLC39a14	47,55	ZIP14	40,45	SLC39a14	ZIP14	23516	23516	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression of the zinc transporter ZIP14 -LRB- SLC39a14 -RRB- is affected by weight_loss and metabolic status and associates with PPARy in human adipose tissue and 3T3-L1 pre-adipocytes .
8921402	0	SLC3A1	59,65	rBAT	48,52	SLC3A1	rBAT	6519	29725(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure and organization of the human rBAT gene -LRB- SLC3A1 -RRB- .
15485886	0	SLC3A2	8,14	beta_1_integrins	33,49	SLC3A2	beta 1 integrins	6520	3688	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	CD98hc -LRB- SLC3A2 -RRB- interaction with beta_1_integrins is required for transformation .
17044855	0	SLC45A2	39,46	MATP	48,52	SLC45A2	MATP	51151	51151	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Distribution of the F374 allele of the SLC45A2 -LRB- MATP -RRB- gene and founder-haplotype analysis .
17358008	0	SLC45A2	36,43	MATP	30,34	SLC45A2	MATP	51151	51151	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter polymorphisms in the MATP -LRB- SLC45A2 -RRB- gene are associated with normal human skin color variation .
22821757	0	SLC45A3	8,15	prostein	25,33	SLC45A3	prostein	85414	85414	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of SLC45A3 protein -LRB- prostein -RRB- expression in prostate_cancer is associated with SLC45A3-ERG_gene_rearrangement and an unfavorable clinical course .
19565014	0	SLC4A1	97,103	AE1	105,108	SLC4A1	AE1	6521	6521	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Molecular mechanisms of autosomal dominant and recessive distal_renal_tubular_acidosis caused by SLC4A1 -LRB- AE1 -RRB- mutations .
20068363	0	SLC4A1	95,101	AE1	103,106	SLC4A1	AE1	6521	6521	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Distal_renal_tubular_acidosis in Filipino children , caused by mutations of the anion-exchanger SLC4A1 -LRB- AE1 , Band 3 -RRB- gene .
14575719	0	SLC4A2	58,64	AE2	32,35	SLC4A2	AE2	6522	6522	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	HNF1alpha upregulates the human AE2 anion exchanger gene -LRB- SLC4A2 -RRB- from an alternate promoter .
14733916	0	SLC4A4	46,52	NBC1	40,44	SLC4A4	NBC1	84484(Tax:10116)	84484(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of electrogenic NBC1 -LRB- SLC4A4 -RRB- variants in rat kidney and pancreas .
20732443	0	SLC5A8	18,24	Smad3	48,53	SLC5A8	Smad3	160728	4088	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Activin_A induces SLC5A8 expression through the Smad3 signaling pathway in human colon_cancer RKO cells .
19637353	0	SLC5A8	13,19	histone_deacetylase_1	50,71	SLC5A8	histone deacetylase 1	160728	3065	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Transport by SLC5A8 with subsequent inhibition of histone_deacetylase_1 -LRB- HDAC1 -RRB- and HDAC3 underlies the antitumor activity of 3-bromopyruvate .
17941974	0	SLC6A1	78,84	GABA_transporter-1	53,71	SLC6A1	GABA transporter-1	6529	6529	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence variation and linkage disequilibrium in the GABA_transporter-1 gene -LRB- SLC6A1 -RRB- in five populations : implications for pharmacogenetic research .
15905073	0	SLC6A14	51,58	ATB0	43,47	SLC6A14	ATB0	11254	6510	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of the amino_acid transporter ATB0 , + -LRB- SLC6A14 -RRB- in colorectal_cancer and metastasis in humans .
16340170	0	SLC6A18	74,81	solute_carrier_family_6_member_18	39,72	SLC6A18	solute carrier family 6 member 18	22598(Tax:10090)	22598(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A nonsense polymorphism -LRB- Y319X -RRB- of the solute_carrier_family_6_member_18 -LRB- SLC6A18 -RRB- gene is not associated with hypertension and blood pressure in Japanese .
21127421	0	SLC6A2	33,39	Norepinephrine_transporter	0,26	SLC6A2	Norepinephrine transporter	6530	6530	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Norepinephrine_transporter gene -LRB- SLC6A2 -RRB- is involved with methylphenidate response in Korean children with attention_deficit_hyperactivity_disorder .
12805287	0	SLC6A2	57,63	norepinephrine_transporter	24,50	SLC6A2	norepinephrine transporter	6530	6530	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A mutation in the human norepinephrine_transporter gene -LRB- SLC6A2 -RRB- associated with orthostatic_intolerance disrupts surface expression of mutant and wild-type transporters .
23185385	0	SLC6A2	82,88	norepinephrine_transporter	49,75	SLC6A2	norepinephrine transporter	6530	6530	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Comprehensive phenotype/genotype analyses of the norepinephrine_transporter gene -LRB- SLC6A2 -RRB- in ADHD : relation to maternal smoking during pregnancy .
24381062	0	SLC6A2	55,61	norepinephrine_transporter	22,48	SLC6A2	norepinephrine transporter	6530	6530	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No association of the norepinephrine_transporter gene -LRB- SLC6A2 -RRB- and cognitive and behavioural phenotypes of patients with autism_spectrum_disorder .
17171650	0	SLC6A3	80,86	DAT	70,73	SLC6A3	DAT	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Dopaminergic polymorphisms in Tourette_syndrome : association with the DAT gene -LRB- SLC6A3 -RRB- .
20450954	0	SLC6A3	16,22	DAT1	24,28	SLC6A3	DAT1	6531	6531	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Variants of the SLC6A3 -LRB- DAT1 -RRB- polymorphism affect performance monitoring-related cortical evoked potentials that are associated with ADHD .
22551036	0	SLC6A3	135,141	OPRM1	103,108	SLC6A3	OPRM1	6531	4988	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm : influence of OPRM1 and dopamine_transporter -LRB- SLC6A3 -RRB- genes .
10418689	0	SLC6A3	97,103	dopamine_transporter	70,90	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Global variation of a 40-bp VNTR in the 3 ' - untranslated region of the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
11739616	0	SLC6A3	31,37	dopamine_transporter	4,24	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The dopamine_transporter gene -LRB- SLC6A3 -RRB- variable number of tandem repeats domain enhances transcription in dopamine neurons .
15608954	0	SLC6A3	76,82	dopamine_transporter	49,69	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of association between VNTR polymorphism of dopamine_transporter gene -LRB- SLC6A3 -RRB- and schizophrenia in a Brazilian sample .
16963468	0	SLC6A3	63,69	dopamine_transporter	36,56	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	5 ' and 3 ' region variability in the dopamine_transporter gene -LRB- SLC6A3 -RRB- , pesticide exposure and Parkinson 's _ disease risk : a hypothesis-generating study .
18094849	0	SLC6A3	92,98	dopamine_transporter	65,85	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association analysis between a VNTR intron 8 polymorphism of the dopamine_transporter gene -LRB- SLC6A3 -RRB- and obsessive - _ compulsive_disorder in a Brazilian sample .
18361424	0	SLC6A3	96,102	dopamine_transporter	69,89	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Family based association study of pediatric bipolar_disorder and the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
18563707	0	SLC6A3	138,144	dopamine_transporter	111,131	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Pharmacogenetics of methylphenidate response in attention_deficit / hyperactivity_disorder : association with the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
19766158	0	SLC6A3	111,117	dopamine_transporter	89,109	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Genetic polymorphisms in the dopamine-2_receptor -LRB- DRD2 -RRB- , dopamine-3_receptor -LRB- DRD3 -RRB- , and dopamine_transporter -LRB- SLC6A3 -RRB- genes in schizophrenia : Data from an association study .
20091113	0	SLC6A3	39,45	dopamine_transporter	17,37	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms in dopamine_transporter -LRB- SLC6A3 -RRB- are associated with stimulant effects of D-amphetamine : an exploratory pharmacogenetic study using healthy volunteers .
20332413	0	SLC6A3	84,90	dopamine_transporter	57,77	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of association between a 3 ` UTR VNTR polymorphism of dopamine_transporter gene -LRB- SLC6A3 -RRB- and ADHD in a Brazilian sample of adult patients .
21050355	0	SLC6A3	103,109	dopamine_transporter	76,96	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relationship between premature_ejaculation and genetic polymorphisms of the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
23162299	0	SLC6A3	86,92	dopamine_transporter	59,79	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of association between the G-660C polymorphism in the dopamine_transporter gene -LRB- SLC6A3 -RRB- and schizophrenia in the Iranian population .
8825631	0	SLC6A3	39,45	dopamine_transporter	4,24	SLC6A3	dopamine transporter	6531	6531	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The dopamine_transporter protein gene -LRB- SLC6A3 -RRB- : primary linkage mapping and linkage studies in Tourette_syndrome .
22268046	0	SLC6A4	15,21	5-HTTLPR	27,35	SLC6A4	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Association of SLC6A4 gene 5-HTTLPR polymorphism with parameters of simple and complex reaction times and critical flicker frequency threshold in athletes during exhaustive exercise .
17987668	0	SLC6A4	26,32	5HTT	20,24	SLC6A4	5HTT	6532	6532	Gene	Gene	relationship|appos|START_ENTITY relationship|nmod|END_ENTITY	The relationship of 5HTT -LRB- SLC6A4 -RRB- methylation and genotype on mRNA expression and liability to major_depression and alcohol_dependence in subjects from the Iowa Adoption Studies .
25710844	0	SLC6A4	48,54	5HTTLPR	78,85	SLC6A4	5HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	A meta-analysis of the associations between the SLC6A4 promoter polymorphism -LRB- 5HTTLPR -RRB- and the risk for alcohol_dependence .
25671637	0	SLC6A4	69,75	Serotonin_Transporter	41,62	SLC6A4	Serotonin Transporter	6532	6532	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Relationship of Genetic Variation in the Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- and Congenital and Acquired Cardiovascular_Diseases .
25849128	0	SLC6A4	87,93	Serotonin_Transporter	59,80	SLC6A4	Serotonin Transporter	6532	6532	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Adverse Life Events and Allele-Specific Methylation of the Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- in Adolescents : The TRAILS Study .
26573471	0	SLC6A4	49,55	Serotonin_Transporter	21,42	SLC6A4	Serotonin Transporter	6532	6532	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	-LSB- Polymorphism in the Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- and Emotional Bipolar_Disorder in Two Regional Mental Health Centers from the Eje Cafetero -LRB- Colombia -RRB- -RSB- .
26822441	0	SLC6A4	28,34	Serotonin_Transporter	0,21	SLC6A4	Serotonin Transporter	6532	6532	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- Methylation Associates With Neonatal Intensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants .
19487392	0	SLC6A4	28,34	Serotonin_transporter	0,21	SLC6A4	Serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonin_transporter gene -LRB- SLC6A4 -RRB- promoter polymorphisms and the susceptibility to posttraumatic_stress_disorder in the general population .
22457857	0	SLC6A4	28,34	Serotonin_transporter	0,21	SLC6A4	Serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonin_transporter gene -LRB- SLC6A4 -RRB- polymorphism in patients with irritable_bowel_syndrome and healthy controls .
9402979	0	SLC6A4	31,37	Serotonin_transporter	0,21	SLC6A4	Serotonin transporter	6532	6532	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Serotonin_transporter protein -LRB- SLC6A4 -RRB- allele and haplotype frequencies and linkage disequilibria in African - and European-American and Japanese populations and in alcohol-dependent subjects .
10713891	0	SLC6A4	52,58	serotonin_transporter	29,50	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Refined mapping of the human serotonin_transporter -LRB- SLC6A4 -RRB- gene within 17q11 adjacent to the CPD and NF1 genes .
11343612	0	SLC6A4	113,119	serotonin_transporter	85,106	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Obsessive-compulsive_disorder and the promoter region polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter gene -LRB- SLC6A4 -RRB- : a negative association study in the Afrikaner population .
16082508	0	SLC6A4	46,52	serotonin_transporter	18,39	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	No association of serotonin_transporter gene -LRB- SLC6A4 -RRB- with schizophrenia and bipolar_disorder in Japanese patients : association analysis based on linkage disequilibrium .
16820721	0	SLC6A4	126,132	serotonin_transporter	103,124	SLC6A4	serotonin transporter	100033848(Tax:9796)	100033848(Tax:9796)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism identification , RH mapping , and association analysis with the anxiety trait of the equine serotonin_transporter -LRB- SLC6A4 -RRB- gene .
18663369	0	SLC6A4	66,72	serotonin_transporter	38,59	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Panic_disorder is associated with the serotonin_transporter gene -LRB- SLC6A4 -RRB- but not the promoter region -LRB- 5-HTTLPR -RRB- .
18824000	0	SLC6A4	96,102	serotonin_transporter	108,129	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4 , the serotonin_transporter gene , which functions to influence all cellular serotonin systems .
18983505	0	SLC6A4	102,108	serotonin_transporter	109,130	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin_transporter polymorphism .
20303273	0	SLC6A4	166,172	serotonin_transporter	138,159	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The association between personality , pain threshold and a single nucleotide polymorphism -LRB- rs3813034 -RRB- in the 3 ' - untranslated region of the serotonin_transporter gene -LRB- SLC6A4 -RRB- .
22311265	0	SLC6A4	45,51	serotonin_transporter	17,38	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Investigation of serotonin_transporter gene -LRB- SLC6A4 -RRB- by child_abuse history interaction with body mass index and diabetes_mellitus of White female depressed psychiatric inpatients .
22594806	0	SLC6A4	73,79	serotonin_transporter	45,66	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between a genetic variant in the serotonin_transporter gene -LRB- SLC6A4 -RRB- and suicidal behavior in patients with schizophrenia .
23630162	0	SLC6A4	59,65	serotonin_transporter	31,52	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Common and rare alleles of the serotonin_transporter gene , SLC6A4 , associated with Tourette 's _ disorder .
24069428	0	SLC6A4	30,36	serotonin_transporter	2,23	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	A serotonin_transporter gene -LRB- SLC6A4 -RRB- polymorphism is associated with reduced risk of irritable_bowel_syndrome in American and Asian population : a meta-analysis .
24392134	0	SLC6A4	43,49	serotonin_transporter	21,42	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Association study of serotonin_transporter SLC6A4 gene with Chinese_Han_irritable_bowel_syndrome .
26261165	0	SLC6A4	38,44	serotonin_transporter	15,36	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of serotonin_transporter -LRB- SLC6A4 -RRB- _ receptor -LRB- 5HTR1A , 5HTR2A -RRB- polymorphisms with response to treatment with escitalopram in patients with major_depressive_disorder : A preliminary study .
9672904	0	SLC6A4	80,86	serotonin_transporter	44,65	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Evidence for linkage disequilibrium between serotonin_transporter protein gene -LRB- SLC6A4 -RRB- and obsessive_compulsive_disorder .
9787878	0	SLC6A4	69,75	serotonin_transporter	31,52	SLC6A4	serotonin transporter	6532	6532	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Functional polymorphism in the serotonin_transporter promoter at the SLC6A4 locus and mood_disorders .
16884688	0	SLC6A5	34,40	GLYT2	27,32	SLC6A5	GLYT2	9152	9152	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations within the human GLYT2 -LRB- SLC6A5 -RRB- gene associated with hyperekplexia .
22700964	0	SLC6A5	29,35	GlyT2	17,22	SLC6A5	GlyT2	9152	9152	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the GlyT2 gene -LRB- SLC6A5 -RRB- are a second major cause of startle_disease .
23103253	0	SLC7A5	65,71	HIF2a	0,5	SLC7A5	HIF2a	8140	2034	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	HIF2a acts as an mTORC1 activator through the amino_acid carrier SLC7A5 .
21439283	0	SLC7A5	76,82	miR-126	0,7	SLC7A5	miR-126	8140	406913	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-126 inhibits proliferation of small_cell_lung_cancer cells by targeting SLC7A5 .
14608357	0	SLC9A3R1	46,54	RUNX1	11,16	SLC9A3R1	RUNX1	9368	861	Gene	Gene	variant|nmod|START_ENTITY variant|compound|END_ENTITY	A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis .
26367500	0	SLCO1B1	43,50	CYP2A6	35,41	SLCO1B1	CYP2A6	10599	1548	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
26367500	0	SLCO1B1	43,50	CYP2C19	26,33	SLCO1B1	CYP2C19	10599	1557	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
24842639	0	SLCO1B1	8,15	CYP2C9	0,6	SLCO1B1	CYP2C9	10599	1559	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|advmod|END_ENTITY	CYP2C9 , SLCO1B1 , SLCO1B3 , and ABCB11 polymorphisms in patients with bosentan-induced liver_toxicity .
26367500	0	SLCO1B1	43,50	CYP2D6	10,16	SLCO1B1	CYP2D6	10599	1565	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|compound|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
26367500	0	SLCO1B1	43,50	CYP3A5	18,24	SLCO1B1	CYP3A5	10599	1577	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Impact of CYP2D6 , CYP3A5 , CYP2C19 , CYP2A6 , SLCO1B1 , ABCB1 , and ABCG2 gene polymorphisms on the pharmacokinetics of simvastatin and simvastatin_acid .
15970799	0	SLCO1B1	31,38	OATP-C	40,46	SLCO1B1	OATP-C	10599	10599	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of SLCO1B1 -LRB- OATP-C -RRB- variants , SLCO1B1 * 5 , SLCO1B1 * 15 and SLCO1B1 * 15 + C1007G , by using transient expression systems of HeLa and HEK293 cells .
19884908	0	SLCO1B1	17,24	OATP1B1	26,33	SLCO1B1	OATP1B1	10599	10599	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The influence of SLCO1B1 -LRB- OATP1B1 -RRB- gene polymorphisms on response to statin therapy .
15970799	0	SLCO1B1	58,65	SLCO1B1	69,76	SLCO1B1	SLCO1B1	10599	10599	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Functional characterization of SLCO1B1 -LRB- OATP-C -RRB- variants , SLCO1B1 * 5 , SLCO1B1 * 15 and SLCO1B1 * 15 + C1007G , by using transient expression systems of HeLa and HEK293 cells .
15970799	0	SLCO1B1	69,76	SLCO1B1	58,65	SLCO1B1	SLCO1B1	10599	10599	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Functional characterization of SLCO1B1 -LRB- OATP-C -RRB- variants , SLCO1B1 * 5 , SLCO1B1 * 15 and SLCO1B1 * 15 + C1007G , by using transient expression systems of HeLa and HEK293 cells .
16758257	0	SLCO1B1	108,115	organic_anion_transporting_polypeptide_1B1	65,107	SLCO1B1	organic anion transporting polypeptide 1B1	10599	10599	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Frequencies of single nucleotide polymorphisms and haplotypes of organic_anion_transporting_polypeptide_1B1 SLCO1B1 gene in a Finnish population .
14739090	0	SLCO1B3	52,59	organic_anion_transporting_polypeptide_8	10,50	SLCO1B3	organic anion transporting polypeptide 8	28234	28234	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human organic_anion_transporting_polypeptide_8 -LRB- SLCO1B3 -RRB- gene is transcriptionally repressed by hepatocyte_nuclear_factor_3beta in hepatocellular_carcinoma .
25126080	0	SLCO2A1	84,91	AKR1B1	43,49	SLCO2A1	AKR1B1	6578	231	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the prostaglandin_F synthase AKR1B1 and the prostaglandin transporter SLCO2A1 in human fetal membranes in relation to spontaneous term and preterm_labor .
16489487	0	SLCO2B1	35,42	OATP2B1	26,33	SLCO2B1	OATP2B1	11309	11309	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human OATP2B1 -LRB- SLCO2B1 -RRB- gene promoter regulation .
23263858	0	SLF	34,37	SCF	30,33	SLF	SCF	4254	4254	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Identification of a canonical SCF -LRB- SLF -RRB- complex involved in S-RNase-based self-incompatibility of Pyrus -LRB- Rosaceae -RRB- .
7679598	0	SLF	47,50	Steel_factor	33,45	SLF	Steel factor	4254	4254	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Decreased endogenous circulating Steel_factor -LRB- SLF -RRB- levels following allogeneic and autologous BMT : lack of an inverse correlation with post-BMT myeloid engraftment .
7677988	0	SLF	56,59	steel_factor	42,54	SLF	steel factor	17311(Tax:10090)	17311(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Follicle-stimulating hormone induction of steel_factor -LRB- SLF -RRB- mRNA in mouse Sertoli cells and stimulation of DNA synthesis in spermatogonia by soluble SLF .
25779942	0	SLFN11	0,6	EWS-FLI1	38,46	SLFN11	EWS-FLI1	91607	2130;2313	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	SLFN11 Is a Transcriptional Target of EWS-FLI1 and a Determinant of Drug Response in Ewing_Sarcoma .
19592487	0	SLFN2	20,25	Schlafen_2	8,18	SLFN2	Schlafen 2	20556(Tax:10090)	20556(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Schlafen_2 -LRB- SLFN2 -RRB- in the generation of interferon alpha-induced growth inhibitory responses .
23286197	0	SLIP1	122,127	SLBP	105,109	SLIP1	SLBP	57409	7884	Gene	Gene	followed|nmod|START_ENTITY END_ENTITY|acl|followed	Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1 .
16762838	0	SLIRP	0,5	SRA	15,18	SLIRP	SRA	81892	10011	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	SLIRP , a small SRA binding protein , is a nuclear receptor corepressor .
10611247	0	SLK	47,50	Caspase_3	0,9	SLK	Caspase 3	9748	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Caspase_3 cleavage of the Ste20-related_kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region .
17003224	0	SLK	52,55	SLK	66,69	SLK	SLK	9748	9748	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The 3 ' - untranslated region of the Ste20-like_kinase SLK regulates SLK expression .
17003224	0	SLK	66,69	SLK	52,55	SLK	SLK	9748	9748	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The 3 ' - untranslated region of the Ste20-like_kinase SLK regulates SLK expression .
12151406	0	SLK	38,41	Ste20-like_kinase	19,36	SLK	Ste20-like kinase	9748	9748	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of the Ste20-like_kinase -LRB- SLK -RRB- with the microtubule .
17003224	0	SLK	52,55	Ste20-like_kinase	34,51	SLK	Ste20-like kinase	9748	9748	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The 3 ' - untranslated region of the Ste20-like_kinase SLK regulates SLK expression .
17003224	0	SLK	66,69	Ste20-like_kinase	34,51	SLK	Ste20-like kinase	9748	9748	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The 3 ' - untranslated region of the Ste20-like_kinase SLK regulates SLK expression .
22053859	4	SLN	680,683	Beta-catenin	642,654	SLN	beta-catenin	6588	1499	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Beta-catenin expression in metastatic SLN -LRB- s -RRB- and liver metastatic lesions was examined by immunohistochemistry .
12777814	0	SLN1	67,71	YPD1	53,57	SLN1	YPD1	854659(Tax:4932)	851363(Tax:4932)	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Co-crystallization of the yeast phosphorelay protein YPD1 with the SLN1 response-regulator domain and preliminary X-ray diffraction analysis .
3998475	0	SLP	43,46	sex-limited_protein	22,41	SLP	sex-limited protein	625018(Tax:10090)	625018(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mice constitutive for sex-limited_protein -LRB- SLP -RRB- expression contain multiple Slp gene sequences .
15694024	0	SLP-2	36,41	stomatin-like_protein_2	11,34	SLP-2	stomatin-like protein 2	30968	30968	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Effect of stomatin-like_protein_2 -LRB- SLP-2 -RRB- gene on growth and proliferation of esophageal_squamous_carcinoma cell line TE12 -RSB- .
23979596	0	SLP-76	26,32	ADAP	47,51	SLP-76	ADAP	3937	2533	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells .
23979596	0	SLP-76	87,93	ADAP	47,51	SLP-76	ADAP	3937	2533	Gene	Gene	oligomerization|nmod|START_ENTITY critical|nmod|oligomerization critical|nsubj|Multipoint Multipoint|nmod|domain domain|nmod|END_ENTITY	Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells .
15668918	0	SLP-76	0,6	CD22	23,27	SLP-76	CD22	16822(Tax:10090)	12483(Tax:10090)	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	SLP-76 is recruited to CD22 and dephosphorylated by SHP-1 , thereby regulating B cell receptor-induced c-Jun_N-terminal_kinase activation .
17010654	0	SLP-76	91,97	GADS	70,74	SLP-76	GADS	3937	9402	Gene	Gene	motif|compound|START_ENTITY complex|nmod|motif peptide|amod|complex END_ENTITY|nmod|peptide	Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction .
12620234	0	SLP-76	89,95	Gads	45,49	SLP-76	Gads	3937	9402	Gene	Gene	peptide|compound|START_ENTITY domain|nmod|peptide domain|compound|END_ENTITY	Structural basis for specific binding of the Gads SH3 domain to an RxxK motif-containing SLP-76 peptide : a novel mode of peptide recognition .
16354835	0	SLP-76	25,31	Gads	48,52	SLP-76	Gads	16822(Tax:10090)	17444(Tax:10090)	Gene	Gene	upstream|compound|START_ENTITY upstream|nmod|site site|compound|END_ENTITY	A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function .
16479002	0	SLP-76	14,20	Gads	38,42	SLP-76	Gads	3937	9402	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells .
16479002	0	SLP-76	74,80	Gads	38,42	SLP-76	Gads	3937	9402	Gene	Gene	clustering|nmod|START_ENTITY inhibits|dobj|clustering inhibits|nsubj|Disruption Disruption|nmod|interaction interaction|nmod|END_ENTITY	Disruption of SLP-76 interaction with Gads inhibits dynamic clustering of SLP-76 and FcepsilonRI signaling in mast cells .
17823979	0	SLP-76	114,120	Gads	121,125	SLP-76	Gads	3937	9402	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	In vivo disruption of T cell development by expression of a dominant-negative polypeptide designed to abolish the SLP-76 / Gads interaction .
10209041	0	SLP-76	53,59	GrpL	0,4	SLP-76	GrpL	3937	9402	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GrpL , a Grb2-related_adaptor_protein , interacts with SLP-76 to regulate nuclear factor of activated T cell activation .
22806433	0	SLP-76	0,6	ICAM-1	76,82	SLP-76	ICAM-1	3937	3383	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	SLP-76 is required for optimal CXCR4-stimulated T lymphocyte firm arrest to ICAM-1 under shear flow .
17420479	0	SLP-76	0,6	ITK	66,69	SLP-76	ITK	3937	3702	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T_cell_antigen_receptor-induced association between SLP-76 and ITK .
17420479	0	SLP-76	130,136	ITK	66,69	SLP-76	ITK	3937	3702	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T_cell_antigen_receptor-induced association between SLP-76 and ITK .
23293025	0	SLP-76	128,134	ITK	17,20	SLP-76	ITK	3937	3702	Gene	Gene	dependent|nmod|START_ENTITY SYK|acl:relcl|dependent Signaling|dep|SYK Signaling|nmod|END_ENTITY	Signaling of the ITK -LRB- interleukin 2-inducible T cell kinase -RRB- - SYK -LRB- spleen tyrosine kinase -RRB- fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70 .
10229072	0	SLP-76	48,54	Nck	15,18	SLP-76	Nck	3937	4690	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes .
9765283	0	SLP-76	0,6	SHP-1	32,37	SLP-76	SHP-1	3937	5777	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors .
10477581	0	SLP-76	0,6	SLP-76	37,43	SLP-76	SLP-76	3937	3937	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	SLP-76 binding to p56lck : a role for SLP-76 in CD4-induced desensitization of the TCR/CD3 signaling complex .
10477581	0	SLP-76	37,43	SLP-76	0,6	SLP-76	SLP-76	3937	3937	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	SLP-76 binding to p56lck : a role for SLP-76 in CD4-induced desensitization of the TCR/CD3 signaling complex .
12084069	0	SLP-76	10,16	Shb	0,3	SLP-76	Shb	3937	6461	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells .
15388330	0	SLP-76	87,93	Src_homology_2_domain-containing_leukocyte_phosphoprotein_of_76_kD	19,85	SLP-76	Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD	3937	3937	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of the Src_homology_2_domain-containing_leukocyte_phosphoprotein_of_76_kD -LRB- SLP-76 -RRB- with the p85 subunit of phosphoinositide_3-kinase .
10021361	0	SLP-76	104,110	gads	43,47	SLP-76	Grb2	3937	2885	Gene	Gene	adaptors|compound|START_ENTITY interactions|nmod|adaptors signaling|nmod|interactions functions|nmod|signaling END_ENTITY|dobj|functions	The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors .
10497204	0	SLP-76	81,87	interleukin_2	105,118	SLP-76	interleukin 2	3937	3558	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Novel isoform of lymphoid adaptor FYN-T-binding_protein -LRB- FYB-130 -RRB- interacts with SLP-76 and up-regulates interleukin_2 production .
10747096	0	SLP-76-associated_protein	26,51	Fyn-binding_protein	0,19	SLP-76-associated protein	Fyn-binding protein	7871	2533	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Fyn-binding_protein -LRB- Fyb -RRB- / SLP-76-associated_protein -LRB- SLAP -RRB- , Ena/vasodilator-stimulated phosphoprotein -LRB- VASP -RRB- proteins and the Arp2/3 complex link T cell receptor -LRB- TCR -RRB- signaling to the actin cytoskeleton .
26793127	0	SLPI	50,54	CCL20	43,48	SLPI	CCL20	6590	6364	Gene	Gene	Cells|nsubj|START_ENTITY Cells|nmod|END_ENTITY	In vivo Cigarette Smoke Exposure Decreases CCL20 , SLPI , and BD-1 Secretion by Human Primary Nasal Epithelial Cells .
26328314	0	SLPI	52,56	Secretory_Leukocyte_Protease_Inhibitor	12,50	SLPI	Secretory Leukocyte Protease Inhibitor	20568(Tax:10090)	20568(Tax:10090)	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Function of Secretory_Leukocyte_Protease_Inhibitor -LRB- SLPI -RRB- in Odontoblast During Mouse Tooth Development .
10704052	0	SLPI	54,58	secretory_leucocyte_protease_inhibitor	14,52	SLPI	secretory leucocyte protease inhibitor	6590	6590	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of secretory_leucocyte_protease_inhibitor -LRB- SLPI -RRB- in human pancreatic beta-cells .
14500739	0	SLPI	124,128	secretory_leukocyte_protease_inhibitor	17,55	SLPI	secretory leukocyte protease inhibitor	84386(Tax:10116)	84386(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Up-regulation of secretory_leukocyte_protease_inhibitor -LRB- SLPI -RRB- in the brain after ischemic_stroke : adenoviral expression of SLPI protects brain from ischemic_injury .
19505578	0	SLPI	93,97	secretory_leukocyte_protease_inhibitor	53,91	SLPI	secretory leukocyte protease inhibitor	6590	6590	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and characterization of recombinant human secretory_leukocyte_protease_inhibitor -LRB- SLPI -RRB- protein from Pichia_pastoris .
8808424	0	SLPI	71,75	secretory_leukocyte_protease_inhibitor	31,69	SLPI	secretory leukocyte protease inhibitor	6590	6590	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of immunoreactive secretory_leukocyte_protease_inhibitor -LRB- SLPI -RRB- in intestinal mucosa .
24285265	0	SLPI	62,66	secretory_leukoprotease_inhibitor	27,60	SLPI	secretory leukoprotease inhibitor	20568(Tax:10090)	20568(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation and activity of secretory_leukoprotease_inhibitor -LRB- SLPI -RRB- is altered in smokers .
17194444	0	SLUG	6,10	CtBP1	37,42	SLUG	CtBP1	6591	1487	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	Human SLUG does not directly bind to CtBP1 .
11912130	0	SLUG	4,8	E-cadherin	39,49	SLUG	E-cadherin	6591	999	Gene	Gene	protein|compound|START_ENTITY represses|nsubj|protein represses|dobj|END_ENTITY	The SLUG zinc-finger protein represses E-cadherin in breast_cancer .
16153441	0	SLUG	57,61	E-cadherin	0,10	SLUG	E-cadherin	6591	999	Gene	Gene	repressor|acl|START_ENTITY regulated|nmod|repressor regulated|nsubjpass|END_ENTITY	E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells .
25982283	0	SLUG	82,86	IMP3	0,4	SLUG	IMP3	6591	10643	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	IMP3 promotes stem-like properties in triple-negative_breast_cancer by regulating SLUG .
25982283	0	SLUG	82,86	IMP3	0,4	SLUG	IMP3	6591	10643	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	IMP3 promotes stem-like properties in triple-negative_breast_cancer by regulating SLUG .
23677615	0	SLUG	129,133	LEF1	113,117	SLUG	LEF1	6591	51176	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 -LRB- SLUG -RRB- .
12955764	0	SLUG	16,20	SNAI2	22,27	SLUG	SNAI2	6591	6591	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Deletion of the SLUG -LRB- SNAI2 -RRB- gene results in human piebaldism .
20128911	0	SLUG	0,4	lymphoid_enhancer_factor-1	22,48	SLUG	lymphoid enhancer factor-1	6591	51176	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	SLUG : a new target of lymphoid_enhancer_factor-1 in human osteoblasts .
21698294	0	SLXL1	0,5	DKKL1	49,54	SLXL1	DKKL1	75140(Tax:10090)	50722(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SLXL1 , a novel acrosomal protein , interacts with DKKL1 and is involved in fertilization in mice .
9615232	0	SM22	53,57	TAGLN	64,69	SM22	TAGLN	6876	6876	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression and cytogenetic localization of the human SM22 gene -LRB- TAGLN -RRB- .
26291555	0	SM22a	15,20	G6PD	49,53	SM22a	G6PD	6876	2539	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	TRAF6-Mediated SM22a K21 Ubiquitination Promotes G6PD Activation and NADPH Production , Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo .
26291555	0	SM22a	15,20	G6PD	49,53	SM22a	G6PD	6876	2539	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	TRAF6-Mediated SM22a K21 Ubiquitination Promotes G6PD Activation and NADPH Production , Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo .
21252119	0	SM22a	41,46	KLF4	64,68	SM22a	KLF4	6876	9314	Gene	Gene	promoter|amod|START_ENTITY represses|dobj|promoter represses|nmod|END_ENTITY	ATRA activates and PDGF-BB represses the SM22a promoter through KLF4 binding to , or dissociating from , its cis-DNA elements .
20924204	0	SM22a	14,19	transgelin	21,31	SM22a	transgelin	25123(Tax:10116)	25123(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of SM22a -LRB- transgelin -RRB- in glomerular and interstitial renal_injury .
22205114	0	SM22a	38,43	transgelin	45,55	SM22a	transgelin	6876	6876	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Quantitative histological analysis of SM22a -LRB- transgelin -RRB- in an adriamycin-induced focal_segmental_glomerulosclerosis model .
18359707	0	SMA	28,31	S-100	33,38	SMA	S-100	6606	6285	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	-LSB- Expression of CD117 , CD34 , SMA , S-100 protein , Vim and desmin in patients with gastrointestinal_stromal_tumors -RSB- .
17466962	0	SMA	102,105	interleukin-8	52,65	SMA	interleukin-8	20589(Tax:10090)	20309(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA , a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice .
10864461	0	SMA-6	56,61	DBL-1	50,55	SMA-6	DBL-1	174044(Tax:6239)	179068(Tax:6239)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	SMA-3 smad has specific and critical functions in DBL-1 / SMA-6 TGFbeta-related signaling .
18172320	0	SMAC	0,4	cytochrome_c	110,122	SMAC	cytochrome c	56616	54205	Gene	Gene	mimetics|nsubj|START_ENTITY mimetics|xcomp|sensitize sensitize|advcl|promoting promoting|dobj|release release|amod|END_ENTITY	SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome_c release .
14500551	0	SMAD-2	88,94	IL-6	24,28	SMAD-2	IL-6	4087	3569	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	TGF-beta down-regulates IL-6 signaling in intestinal epithelial cells : critical role of SMAD-2 .
25870111	0	SMAD1	0,5	FLI1	57,61	SMAD1	FLI1	4086	2313	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	SMAD1 and SMAD5 expression is co-ordinately regulated by FLI1 and GATA2 during endothelial development .
18197755	0	SMAD1	115,120	miR-26a	90,97	SMAD1	miR-26a	4086	407015	Gene	Gene	factor|compound|START_ENTITY END_ENTITY|nmod|factor	Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor .
23259454	0	SMAD2	21,26	NKX2-1	0,6	SMAD2	NKX2-1	4087	7080	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	NKX2-1 activation by SMAD2 signaling after definitive endoderm differentiation in human embryonic stem cell .
21611174	0	SMAD2	84,89	TGF-b	60,65	SMAD2	TGF-b	17126(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Wnt3a induces myofibroblast differentiation by upregulating TGF-b signaling through SMAD2 in a b-catenin-dependent manner .
26039994	0	SMAD2	44,49	TGF-b	63,68	SMAD2	TGF-b	31738(Tax:7227)	7040	Gene	Gene	release|compound|START_ENTITY impedes|dobj|release impedes|nmod|receptor receptor|amod|END_ENTITY	Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-b receptor I to inhibit TGF-b signaling .
26039994	0	SMAD2	44,49	TGF-b	91,96	SMAD2	TGF-b	31738(Tax:7227)	37778(Tax:7227)	Gene	Gene	release|compound|START_ENTITY impedes|dobj|release impedes|nmod|receptor receptor|acl|inhibit inhibit|dobj|signaling signaling|amod|END_ENTITY	Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-b receptor I to inhibit TGF-b signaling .
18166170	0	SMAD2/3	20,27	Activin	0,7	SMAD2/3	Activin	4087;4088	83729	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression .
24601881	0	SMAD2/3	53,60	BMP_type_1A_receptor	79,99	SMAD2/3	BMP type 1A receptor	17126;17127	12166(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Bone_morphogenetic_protein_2 stimulates noncanonical SMAD2/3 signaling via the BMP_type_1A_receptor in gonadotrope-like cells : implications for FSH synthesis .
24601881	0	SMAD2/3	53,60	Bone_morphogenetic_protein_2	0,28	SMAD2/3	Bone morphogenetic protein 2	17126;17127	12156(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Bone_morphogenetic_protein_2 stimulates noncanonical SMAD2/3 signaling via the BMP_type_1A_receptor in gonadotrope-like cells : implications for FSH synthesis .
22511296	0	SMAD2/3	24,31	TGF-b	0,5	SMAD2/3	TGF-b	4087;4088	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	TGF-b signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment .
26932538	0	SMAD3	115,120	MiR-708	0,7	SMAD3	MiR-708	4088	100126333	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-708 promotes steroid-induced osteonecrosis of femoral head , suppresses osteogenic differentiation by targeting SMAD3 .
24627133	0	SMAD3	15,20	PTTG1	0,5	SMAD3	PTTG1	4088	9232	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	PTTG1 inhibits SMAD3 in prostate_cancer cells to promote their proliferation .
23541743	0	SMAD3	111,116	TGF-b1	104,110	SMAD3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	effect|parataxis|START_ENTITY effect|nmod|inhibition inhibition|nmod|END_ENTITY	The effect of curcumin on sepsis-induced acute_lung_injury in a rat model through the inhibition of the TGF-b1 / SMAD3 pathway .
23576639	0	SMAD3	98,103	TGF-b1	41,47	SMAD3	TGF-b1	4088	7040	Gene	Gene	activity|nummod|START_ENTITY fluctuations|nmod|activity defines|dobj|fluctuations defines|nsubj|antagonism antagonism|nmod|END_ENTITY	Notch4-dependent antagonism of canonical TGF-b1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells .
10064594	0	SMAD3	23,28	TGF-beta	106,114	SMAD3	TGF-beta	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	results|nummod|START_ENTITY disruption|nmod|results responsiveness|nsubj|disruption responsiveness|nmod|END_ENTITY	Targeted disruption of SMAD3 results in impaired_mucosal_immunity and diminished T cell responsiveness to TGF-beta .
18768831	0	SMAD3	18,23	TGF-beta	0,8	SMAD3	TGF-beta	4088	7040	Gene	Gene	START_ENTITY|nsubj|utilizes utilizes|amod|END_ENTITY	TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent_cellular_cytotoxicity in human NK cells .
27054113	0	SMAD3	32,37	TGFb	87,91	SMAD3	TGFb	4088	7040	Gene	Gene	Transcript|compound|START_ENTITY Interaction|nmod|Transcript Supports|nsubj|Interaction Supports|nmod|Pathway Pathway|compound|END_ENTITY	Hsa-miR-590-5p Interaction with SMAD3 Transcript Supports Its Regulatory Effect on The TGFb Signaling Pathway .
21896644	0	SMAD3	20,25	TRB3	0,4	SMAD3	TRB3	4088	57761	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRB3 interacts with SMAD3 promoting tumor cell migration and invasion .
12161428	0	SMAD3	99,104	Transforming_growth_factor-beta	0,31	SMAD3	Transforming growth factor-beta	4088	7040	Gene	Gene	interactions|nummod|START_ENTITY inhibits|nmod|interactions inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits pulmonary surfactant_protein_B gene transcription through SMAD3 interactions with NKX2 .1 and HNF-3 transcription factors .
17881189	0	SMAD3	60,65	Transforming_growth_factor-beta	0,31	SMAD3	Transforming growth factor-beta	4088	7040	Gene	Gene	factors|compound|START_ENTITY telomerase|nmod|factors inhibits|xcomp|telomerase inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits telomerase through SMAD3 and E2F transcription factors .
25934839	0	SMAD3	0,5	irisin	33,39	SMAD3	irisin	4088	252995	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor y coactivator 1-a -LRB- PGC-1a -RRB- during exercise .
17197157	0	SMAD3	0,5	mitogen-activated_protein_kinase_kinase-1	33,74	SMAD3	mitogen-activated protein kinase kinase-1	4088	5604	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	SMAD3 expression is regulated by mitogen-activated_protein_kinase_kinase-1 in epithelial and smooth muscle cells .
22781750	0	SMAD3	32,37	transforming_growth_factor-b	54,82	SMAD3	transforming growth factor-b	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	function|compound|START_ENTITY function|nmod|pathway pathway|amod|END_ENTITY	Protein phosphatase 5 modulates SMAD3 function in the transforming_growth_factor-b pathway .
24550394	0	SMAD3	153,158	transforming_growth_factor-b	96,124	SMAD3	transforming growth factor-b	4088	7040	Gene	Gene	activation|compound|START_ENTITY promoting|dobj|activation signaling|advcl|promoting pathway|acl|signaling pathway|acl:relcl|leads leads|nmod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming_growth_factor-b -LRB- TGF-b -RRB- signaling promoting SMAD3 activation and fibrosis via Gremlin protein .
25264609	0	SMAD4	0,5	N-Cadherin	55,65	SMAD4	N-Cadherin	4089	1000	Gene	Gene	Motility|compound|START_ENTITY Motility|nmod|END_ENTITY	SMAD4 Regulates Cell Motility through Transcription of N-Cadherin in Human Pancreatic Ductal Epithelium .
26409456	0	SMAD4	23,28	SMAD5	30,35	SMAD4	SMAD5	4089	4090	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
21874046	0	SMAD4	74,79	TGF-b	54,59	SMAD4	TGF-b	4089	7040	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|dobj|transduction transduction|nmod|END_ENTITY	MicroRNA miR-146b-5p regulates signal transduction of TGF-b by repressing SMAD4 in thyroid_cancer .
26284758	0	SMAD4	14,19	TGF-b	76,81	SMAD4	TGF-b	4089	7040	Gene	Gene	Insights|nmod|START_ENTITY Loss|nsubj|Insights Loss|nmod|Restoration Restoration|nmod|Signaling Signaling|compound|END_ENTITY	Insights Into SMAD4 Loss in Pancreatic_Cancer From Inducible Restoration of TGF-b Signaling .
26409456	0	SMAD4	23,28	miR-548n	13,21	SMAD4	miR-548n	4089	100302152	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
22243968	0	SMAD4	42,47	tumor-suppressor	48,64	SMAD4	tumor-suppressor	4089	7248	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre_syndrome .
26409456	0	SMAD5	30,35	SMAD4	23,28	SMAD5	SMAD4	4090	4089	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
26409456	0	SMAD5	30,35	miR-548n	13,21	SMAD5	miR-548n	4090	100302152	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
25501551	0	SMAD7	27,32	Micro-RNA_21	0,12	SMAD7	Micro-RNA 21	4092	406991	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Micro-RNA_21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic_steatohepatitis .
21898545	0	SMAD7	102,107	TGF-b	30,35	SMAD7	TGF-b	4092	7040	Gene	Gene	regulation|nmod|START_ENTITY involve|dobj|regulation involve|nsubj|degradation degradation|nmod|receptors receptors|amod|END_ENTITY	CD109-mediated degradation of TGF-b receptors and inhibition of TGF-b responses involve regulation of SMAD7 and Smurf2 localization and function .
24935472	0	SMAD7	0,5	TGF-b	46,51	SMAD7	TGF-b	4092	7040	Gene	Gene	START_ENTITY|dep|timer timer|nmod|progression progression|acl|targeting targeting|dobj|signaling signaling|amod|END_ENTITY	SMAD7 : a timer of tumor progression targeting TGF-b signaling .
25983322	0	SMAD7	84,89	TGF-b	0,5	SMAD7	TGF-b	4092	7040	Gene	Gene	expression|compound|START_ENTITY inhibiting|dobj|expression signaling|advcl|inhibiting TGF-b|acl|signaling activation|nmod|TGF-b enhances|dobj|activation enhances|nsubj|END_ENTITY	TGF-b induced miR-132 enhances the activation of TGF-b signaling through inhibiting SMAD7 expression in glioma cells .
25983322	0	SMAD7	84,89	TGF-b	49,54	SMAD7	TGF-b	4092	7040	Gene	Gene	expression|compound|START_ENTITY inhibiting|dobj|expression signaling|advcl|inhibiting END_ENTITY|acl|signaling	TGF-b induced miR-132 enhances the activation of TGF-b signaling through inhibiting SMAD7 expression in glioma cells .
19032343	0	SMAD7	91,96	TGF-beta	69,77	SMAD7	TGF-beta	4092	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene , SMAD7 , via HDAC3 and PRMT5 .
23633623	0	SMAD7	0,5	TGFb	22,26	SMAD7	TGFb	17131(Tax:10090)	21803(Tax:10090)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|superfamily superfamily|compound|END_ENTITY	SMAD7 antagonizes key TGFb superfamily signaling in mouse granulosa cells in vitro .
23709694	0	SMAD7	61,66	TGFb	15,19	SMAD7	TGFb	17131(Tax:10090)	21803(Tax:10090)	Gene	Gene	downregulating|dobj|START_ENTITY mediates|advcl|downregulating mediates|dobj|sensitivity sensitivity|compound|END_ENTITY	Cbl-b mediates TGFb sensitivity by downregulating inhibitory SMAD7 in primary T cells .
19620243	0	SMAD_anchor_for_receptor_activation	14,49	SARA	8,12	SMAD anchor for receptor activation	SARA	9372	9372	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of SARA -LRB- SMAD_anchor_for_receptor_activation -RRB- in maintenance of epithelial cell phenotype .
23922662	0	SMAD_family_member_4	21,41	MicroRNA-224	0,12	SMAD family member 4	MicroRNA-224	4089	407009	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-224 targets SMAD_family_member_4 to promote cell proliferation and negatively influence patient survival .
9644265	0	SMAP-1	52,58	stromal_membrane-associated_protein	15,50	SMAP-1	stromal membrane-associated protein	98366(Tax:10090)	98366(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of stromal_membrane-associated_protein -LRB- SMAP-1 -RRB- in erythropoietic microenvironment .
18822384	0	SMAR1	17,22	Cytokeratin_8	37,50	SMAR1	Cytokeratin 8	54971	3856	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Tumor suppressor SMAR1 downregulates Cytokeratin_8 expression by displacing p53 from its cognate site .
22978699	0	SMAR1	34,39	GAD65	14,19	SMAR1	GAD65	53325(Tax:10090)	14417(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment .
18981184	0	SMAR1	17,22	IkappaBalpha	33,45	SMAR1	IkappaBalpha	54971	4792	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Tumor suppressor SMAR1 represses IkappaBalpha expression and inhibits p65 transactivation through matrix attachment regions .
25239884	0	SMAR1	29,34	Interleukin-8	61,74	SMAR1	Interleukin-8	54971	3576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Chromatin remodeling protein SMAR1 regulates NF-kB dependent Interleukin-8 transcription in breast_cancer .
16166625	0	SMAR1	17,22	cyclin_D1	32,41	SMAR1	cyclin D1	53325(Tax:10090)	12443(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|repression repression|amod|END_ENTITY	Tumor suppressor SMAR1 mediates cyclin_D1 repression by recruitment of the SIN3/histone deacetylase 1 complex .
23876508	0	SMAR1	73,78	miR-320a	0,8	SMAR1	miR-320a	54971	407037	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR-320a regulates erythroid differentiation through MAR binding protein SMAR1 .
15701641	0	SMAR1	17,22	p53	48,51	SMAR1	p53	53325(Tax:10090)	22060(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif .
18822384	0	SMAR1	17,22	p53	76,79	SMAR1	p53	54971	7157	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|END_ENTITY	Tumor suppressor SMAR1 downregulates Cytokeratin_8 expression by displacing p53 from its cognate site .
22074660	0	SMAR1	30,35	p53	45,48	SMAR1	p53	54971	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transactivation transactivation|nummod|END_ENTITY	Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300 .
26629941	0	SMAR1	18,23	p53	106,109	SMAR1	p53	54971	7157	Gene	Gene	Radiosensitivity|compound|START_ENTITY Overexpression|nmod|Radiosensitivity Overexpression|nmod|Pathway Pathway|compound|END_ENTITY	Overexpression of SMAR1 Enhances Radiosensitivity in Human Breast Cancer Cell Line MCF7 via Activation of p53 Signaling Pathway .
24421395	0	SMARCA4	76,83	BRG1	85,89	SMARCA4	BRG1	6597	6597	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Residual complexes containing SMARCA2 -LRB- BRM -RRB- underlie the oncogenic drive of SMARCA4 -LRB- BRG1 -RRB- mutation .
27100627	0	SMARCA4	8,15	BRG1	17,21	SMARCA4	BRG1	6597	6597	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Loss of SMARCA4 -LRB- BRG1 -RRB- Protein Expression by Immunohistochemistry in Small Cell Carcinoma_of_the_Ovary , Hypercalcemic Type Distinguishes these Tumors from their Mimics .
23873943	0	SMARCAL1	19,27	ATR	0,3	SMARCAL1	ATR	50485	545	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	ATR phosphorylates SMARCAL1 to prevent replication fork collapse .
21566516	0	SMARCB1	109,116	INI1	118,122	SMARCB1	INI1	6598	6598	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nonsense mutation and inactivation of SMARCA4 -LRB- BRG1 -RRB- in an atypical teratoid/rhabdoid _ tumor showing retained SMARCB1 -LRB- INI1 -RRB- expression .
22949514	0	SMARCB1	14,21	INI1	23,27	SMARCB1	INI1	6598	6598	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of SMARCB1 -LRB- INI1 -RRB- mutations in familial_schwannomatosis .
22479537	0	SMARCB1	32,39	UL114	92,97	SMARCB1	UL114	6598	3077539(Tax:10359)	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	The chromatin remodeling factor SMARCB1 forms a complex with human_cytomegalovirus proteins UL114 and UL44 .
25656847	0	SMARCE1	0,7	EGFR	19,23	SMARCE1	EGFR	6605	1956	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung_cancer .
19636912	0	SMCX	111,115	JARID1C	102,109	SMCX	JARID1C	8242	8242	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Backbone and sidechain 1H , 13C and 15N resonance assignments of the Bright/ARID domain from the human JARID1C -LRB- SMCX -RRB- protein .
20599799	0	SMG-1	24,29	FMLP_receptor	43,56	SMG-1	FMLP receptor	23049	2357	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	The hederagenin_saponin SMG-1 is a natural FMLP_receptor inhibitor that suppresses human neutrophil activation .
11113196	0	SMG-4	139,144	Upf2	85,89	SMG-4	Upf2	179371(Tax:6239)	856476(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Identification and characterization of human orthologues to Saccharomyces_cerevisiae Upf2 protein and Upf3 protein -LRB- Caenorhabditis_elegans SMG-4 -RRB- .
21640080	0	SMG-9	38,43	SMG-9	58,63	SMG-9	SMG-9	56006	56006	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex .
21640080	0	SMG-9	58,63	SMG-9	38,43	SMG-9	SMG-9	56006	56006	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex .
21701263	0	SMG1	29,33	p53	44,47	SMG1	p53	23049	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA .
21994947	0	SMILE	99,104	CREBH	191,196	SMILE	CREBH	58487	84699	Gene	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE -LRB- small_heterodimer_partner-interacting_leucine_zipper_protein -RRB- - mediated inhibition of CREBH -LRB- cAMP_responsive_element-binding_protein_H -RRB- .
19690166	0	SMILE	28,33	SIRT1	43,48	SMILE	SIRT1	58487	23411	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen_receptor-related_receptor_gamma transactivation .
25199764	0	SMILE	0,5	androgen_receptor	56,73	SMILE	androgen receptor	58487	367	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	SMILE upregulated by metformin inhibits the function of androgen_receptor in prostate_cancer cells .
24389415	0	SMILE	0,5	osteocalcin	43,54	SMILE	osteocalcin	233490(Tax:10090)	12097(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	SMILE inhibits BMP-2-induced expression of osteocalcin by suppressing the activity of the RUNX2 transcription factor in MC3T3E1 cells .
9458713	0	SMIT	23,27	TNF-alpha	10,19	SMIT	TNF-alpha	282362(Tax:9913)	280943(Tax:9913)	Gene	Gene	levels|amod|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells .
16420717	0	SMIT-1	36,42	Sodium-myo-inositol_co-transporter	0,34	SMIT-1	Sodium-myo-inositol co-transporter	6526	6526	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Sodium-myo-inositol_co-transporter -LRB- SMIT-1 -RRB- mRNA is increased in neutrophils of patients with bipolar_1_disorder and down-regulated under treatment with mood stabilizers .
10970187	0	SMN	40,43	Bcl-2	59,64	SMN	Bcl-2	6606	596	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Does the survival_motor_neuron_protein -LRB- SMN -RRB- interact with Bcl-2 ?
18675250	0	SMN	76,79	Gemin4	100,106	SMN	Gemin4	6606	50628	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification and characterisation of a nuclear localisation signal in the SMN associated protein , Gemin4 .
14715275	0	SMN	21,24	Rpp20	0,5	SMN	Rpp20	252667	3772007(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress .
12075005	0	SMN	23,26	Survival_motor_neuron	0,21	SMN	Survival motor neuron	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Survival_motor_neuron -LRB- SMN -RRB- protein : role in neurite outgrowth and neuromuscular maturation during neuronal differentiation and development .
9758161	0	SMN	23,26	Survival_motor_neuron	0,21	SMN	Survival motor neuron	64301(Tax:10116)	64301(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Survival_motor_neuron -LRB- SMN -RRB- protein in rat is expressed as different molecular forms and is developmentally regulated .
10749974	0	SMN	97,100	survival_motor_neuron	74,95	SMN	survival motor neuron	6606	6606	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Characterization of the Schizosaccharomyces_pombe orthologue of the human survival_motor_neuron -LRB- SMN -RRB- protein .
11085591	0	SMN	27,30	survival_motor_neuron	4,25	SMN	survival motor neuron	6606	6606	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The survival_motor_neuron -LRB- SMN -RRB- protein : effect of exon loss and mutation on protein localization .
14742439	0	SMN	147,150	survival_motor_neuron	124,145	SMN	survival motor neuron	6606	6606	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel cyclic_AMP-response element -LRB- CRE-II -RRB- and the role of CREB-1 in the cAMP-induced expression of the survival_motor_neuron -LRB- SMN -RRB- gene .
15361068	0	SMN	47,50	survival_motor_neuron	24,45	SMN	survival motor neuron	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Characterization of the survival_motor_neuron -LRB- SMN -RRB- promoter provides evidence for complex combinatorial regulation in undifferentiated and differentiated P19 cells .
21082361	0	SMN	40,43	survival_motor_neuron	17,38	SMN	survival motor neuron	6606	6606	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Mutations in the survival_motor_neuron -LRB- SMN -RRB- protein alter the dynamic nature of nuclear bodies .
9600994	0	SMN	97,100	survival_motor_neuron	74,95	SMN	survival motor neuron	6606	6606	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Heterogeneity of subcellular localization and electrophoretic mobility of survival_motor_neuron -LRB- SMN -RRB- protein in mammalian neural cells and tissues .
15767679	0	SMN	95,98	survival_motor_neurons	71,93	SMN	survival motor neurons	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	ZPR1 is essential for survival and is required for localization of the survival_motor_neurons -LRB- SMN -RRB- protein to Cajal bodies .
11181573	0	SMN	43,46	survival_of_motor_neuron	17,41	SMN	survival of motor neuron	6606	6606	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Co-regulation of survival_of_motor_neuron -LRB- SMN -RRB- protein and its interactor SIP1 during development and in spinal_muscular_atrophy .
12030329	0	SMN	44,47	survival_of_motor_neuron	18,42	SMN	survival of motor neuron	64301(Tax:10116)	64301(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the survival_of_motor_neuron -LRB- SMN -RRB- gene in primary neurons and increase in SMN levels by activation of the N-methyl-D-aspartate_glutamate receptor .
12221125	0	SMN	45,48	survival_of_motor_neuron	19,43	SMN	survival of motor neuron	6606	6606	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The product of the survival_of_motor_neuron -LRB- SMN -RRB- gene is a human telomerase-associated protein .
14697339	0	SMN	98,101	survival_of_motor_neuron	72,96	SMN	survival of motor neuron	6606	6606	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Ultrastructural characterisation of a nuclear domain highly enriched in survival_of_motor_neuron -LRB- SMN -RRB- protein .
20826664	0	SMN	34,37	survival_of_motor_neuron	8,32	SMN	survival of motor neuron	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Reduced survival_of_motor_neuron -LRB- SMN -RRB- protein in motor neuronal progenitors functions cell autonomously to cause spinal_muscular_atrophy in model mice expressing the human centromeric -LRB- SMN2 -RRB- gene .
23897586	0	SMN	38,41	survival_of_motor_neuron	12,36	SMN	survival of motor neuron	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Dynamics of survival_of_motor_neuron -LRB- SMN -RRB- protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons .
10942426	0	SMN	84,87	survival_of_motor_neurons	57,82	SMN	survival of motor neurons	6606	6606	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Characterization of a nuclear 20S complex containing the survival_of_motor_neurons -LRB- SMN -RRB- protein and a specific subset of spliceosomal Sm proteins .
18078930	0	SMN1	38,42	SMN2	25,29	SMN1	SMN2	6606	6607	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Genetic conversion of an SMN2 gene to SMN1 : a novel approach to the treatment of spinal_muscular_atrophy .
15586177	0	SMN1	76,80	survival_motor_neuron	53,74	SMN1	survival motor neuron	6606	6606	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Somatic mosaicism for a heterozygous deletion of the survival_motor_neuron -LRB- SMN1 -RRB- gene .
18078930	0	SMN2	25,29	SMN1	38,42	SMN2	SMN1	6607	6606	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Genetic conversion of an SMN2 gene to SMN1 : a novel approach to the treatment of spinal_muscular_atrophy .
18794368	0	SMN2	100,104	survival_motor_neuron_2	75,98	SMN2	survival motor neuron 2	6607	6607	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The RNA binding protein hnRNP_Q modulates the utilization of exon 7 in the survival_motor_neuron_2 -LRB- SMN2 -RRB- gene .
20947812	0	SMN2	45,49	survivor_motor_neuron_2	20,43	SMN2	survivor motor neuron 2	6607	6607	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between survivor_motor_neuron_2 -LRB- SMN2 -RRB- gene homozygous deletion and sporadic lower_motor_neuron_disease in a Korean population .
19409521	0	SMNA	30,34	IFRD1	0,5	SMNA	IFRD1	94008	3475	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	IFRD1 is a candidate gene for SMNA on chromosome 7q22-q23 .
20946629	0	SMO	18,21	Spermine_oxidase	0,16	SMO	Spermine oxidase	54498	54498	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Spermine_oxidase -LRB- SMO -RRB- activity in breast_tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm .
24502520	0	SMO	73,76	smoothened_receptor	52,71	SMO	smoothened receptor	6608	6608	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Development of a concise , asymmetric synthesis of a smoothened_receptor -LRB- SMO -RRB- inhibitor : enzymatic transamination of a 4-piperidinone with dynamic kinetic resolution .
19578009	0	SMOC-1	56,62	TGF-beta	33,41	SMOC-1	TGF-beta	314280(Tax:10116)	59086(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Nitric_oxide inhibits glomerular TGF-beta signaling via SMOC-1 .
17989364	0	SMOC-2	25,31	cyclin_D1	63,72	SMOC-2	cyclin D1	64074(Tax:10090)	12443(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin_D1 expression and DNA synthesis via integrin-linked_kinase .
17989364	0	SMOC-2	25,31	integrin-linked_kinase	106,128	SMOC-2	integrin-linked kinase	64074(Tax:10090)	16202(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin_D1 expression and DNA synthesis via integrin-linked_kinase .
25750188	0	SMOC1	52,57	secreted_modular_calcium-binding_protein_1	8,50	SMOC1	secreted modular calcium-binding protein 1	64075(Tax:10090)	64075(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of secreted_modular_calcium-binding_protein_1 -LRB- SMOC1 -RRB- in transforming growth factor b signalling and angiogenesis .
21347421	0	SMP30	30,35	Senescence_marker_protein_30	0,28	SMP30	Senescence marker protein 30	9104	9104	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Senescence_marker_protein_30 -LRB- SMP30 -RRB- expression in eukaryotic cells : existence of multiple species and membrane localization .
15944925	0	SMP30	66,71	senescence_marker_protein-30	36,64	SMP30	senescence marker protein-30	19733(Tax:10090)	19733(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of senescence_marker_protein-30 -LRB- SMP30 -RRB- in the submandibular gland and ultrastructural changes of the granular duct cells in SMP30 knockout mice .
19482009	0	SMP30	81,86	senescence_marker_protein-30	51,79	SMP30	senescence marker protein-30	19733(Tax:10090)	19733(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Effects of vitamin_C deficiency on the skin of the senescence_marker_protein-30 -LRB- SMP30 -RRB- knockout mouse .
26809095	0	SMPD1	61,66	ASMase	53,59	SMPD1	ASMase	6609	6609	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Resveratrol-induced transcriptional up-regulation of ASMase -LRB- SMPD1 -RRB- of human leukemia and cancer cells .
25811928	0	SMPD1	117,122	Sphingomyelin_Phosphodiesterase_1	82,115	SMPD1	Sphingomyelin Phosphodiesterase 1	6609	6609	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Four Novel p.N385K , p.V36A , c.1033-1034insT and c.1417-1418delCT Mutations in the Sphingomyelin_Phosphodiesterase_1 -LRB- SMPD1 -RRB- Gene in Patients with Types A and B Niemann-Pick_Disease -LRB- NPD -RRB- .
2004772	0	SMPD1	61,66	acid_sphingomyelinase	33,54	SMPD1	acid sphingomyelinase	6609	6609	Gene	Gene	assignment|appos|START_ENTITY assignment|nmod|gene gene|compound|END_ENTITY	Regional assignment of the human acid_sphingomyelinase gene -LRB- SMPD1 -RRB- by PCR analysis of somatic cell hybrids and in situ hybridization to 11p15 .1 -- p15 .4 .
12607113	0	SMPD1	66,71	sphingomyelin_phosphodiesterase-1	31,64	SMPD1	sphingomyelin phosphodiesterase-1	6609	6609	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Compound heterozygosity at the sphingomyelin_phosphodiesterase-1 -LRB- SMPD1 -RRB- gene is associated with low HDL cholesterol .
23618813	0	SMPD1	56,61	sphingomyelin_phosphodiesterase_1	16,49	SMPD1	sphingomyelin phosphodiesterase 1	6609	6609	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the sphingomyelin_phosphodiesterase_1 gene -LRB- SMPD1 -RRB- in Turkish Niemann-Pick_disease patients : mutation profile and description of a novel mutation .
26851015	0	SMR3A	64,69	Submaxillary_Gland_Androgen-regulated_Protein_3A	14,62	SMR3A	Submaxillary Gland Androgen-regulated Protein 3A	26952	26952	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Submaxillary_Gland_Androgen-regulated_Protein_3A -LRB- SMR3A -RRB- in Adenoid_Cystic_Carcinoma of the Head_and_Neck .
23093275	0	SMRP	94,98	soluble_mesothelin-related_protein	58,92	SMRP	soluble mesothelin-related protein	10232	10232	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	A predictive equation to adjust for clinical variables in soluble_mesothelin-related_protein -LRB- SMRP -RRB- levels .
18838553	0	SMRT	66,70	Cdk2	0,4	SMRT	Cdk2	9612	1017	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT .
10809664	0	SMRT	7,11	HDAC3	43,48	SMRT	HDAC3	9612	8841	Gene	Gene	START_ENTITY|xcomp|containing containing|dobj|END_ENTITY	A core SMRT corepressor complex containing HDAC3 and TBL1 , a WD40-repeat protein linked to deafness .
24449765	0	SMRT	46,50	p53	14,17	SMRT	p53	9612	7157	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Activation of p53 transcriptional activity by SMRT : a histone_deacetylase_3-independent function of a transcriptional corepressor .
11435691	0	SMRT	146,150	silencing_mediator_of_retinoid_and_thyroid_hormone_receptor	85,144	SMRT	silencing mediator of retinoid and thyroid hormone receptor	9612	9612	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization and refined mapping of the human nuclear_corepressor_2 -LRB- NCOR2 -RRB- / silencing_mediator_of_retinoid_and_thyroid_hormone_receptor -LRB- SMRT -RRB- gene on chromosome 12q24 .3 .
11304536	0	SMRTE	0,5	HDAC4	61,66	SMRTE	HDAC4	9612	9759	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains .
17616479	0	SMS	38,41	sphingomyelin_synthase	14,36	SMS	sphingomyelin synthase	6611	6611	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of sphingomyelin_synthase -LRB- SMS -RRB- affects intracellular sphingomyelin accumulation and plasma membrane lipid organization .
18694848	0	SMS	51,54	sphingomyelin_synthase	27,49	SMS	sphingomyelin synthase	6611	6611	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	The domain responsible for sphingomyelin_synthase -LRB- SMS -RRB- activity .
11283016	0	SMT3b	77,82	striated_muscle_RING_zinc_finger_protein	14,54	SMT3b	striated muscle RING zinc finger protein	6613	84676	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	A novel human striated_muscle_RING_zinc_finger_protein , SMRZ , interacts with SMT3b via its RING domain .
23033319	0	SMTN	31,35	smoothelin	19,29	SMTN	smoothelin	6525	6525	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the smoothelin -LRB- SMTN -RRB- gene with cerebral_infarction in men : a haplotype-based case-control study .
23246433	0	SMUG1	38,43	DKC1	68,72	SMUG1	DKC1	23583	1736	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control .
26166038	0	SMURF2	65,71	miR-15b	0,7	SMURF2	miR-15b	64750	406949	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic_cancer .
26166038	0	SMURF2	65,71	miR-15b	0,7	SMURF2	miR-15b	64750	406949	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic_cancer .
19783823	0	SMYD1	0,5	serum_response_factor	53,74	SMYD1	serum response factor	12180(Tax:10090)	20807(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	SMYD1 , the myogenic activator , is a direct target of serum_response_factor and myogenin .
26676636	0	SMYD3	12,17	BCLAF1	67,73	SMYD3	BCLAF1	64754	9774	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Upregulated SMYD3 promotes bladder_cancer progression by targeting BCLAF1 and activating autophagy .
21054678	0	SMYD3	0,5	Tax	28,31	SMYD3	Tax	64754	1491938(Tax:11908)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SMYD3 interacts with HTLV-1 Tax and regulates subcellular localization of Tax .
24174655	0	SMYD3	0,5	androgen_receptor	66,83	SMYD3	androgen receptor	64754	367	Gene	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	SMYD3 as an oncogenic driver in prostate_cancer by stimulation of androgen_receptor transcription .
12053071	0	SMemb	46,51	nonmuscle_myosin_heavy_chain_B	14,44	SMemb	nonmuscle myosin heavy chain B	79433(Tax:10116)	79433(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of nonmuscle_myosin_heavy_chain_B -LRB- SMemb -RRB- in rat allogeneic kidney transplantation .
24106489	0	SN1	67,70	Protein_Kinase_C	0,16	SN1	Protein Kinase C	10991	112476	Gene	Gene	Phosphorylates|dobj|START_ENTITY Phosphorylates|nsubj|END_ENTITY	Protein_Kinase_C Phosphorylates the System N Glutamine Transporter SN1 -LRB- Slc38a3 -RRB- and Regulates Its Membrane Trafficking and Degradation .
19055748	0	SNAI1	33,38	PAI-1	0,5	SNAI1	PAI-1	6615	5054	Gene	Gene	blockade|nmod|START_ENTITY blockade|amod|END_ENTITY	PAI-1 and functional blockade of SNAI1 in breast_cancer cell migration .
10585766	0	SNAI1	83,88	SNAIL	71,76	SNAI1	SNAIL	6615	6615	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization , expression , and chromosome location of the human SNAIL gene -LRB- SNAI1 -RRB- and a related processed pseudogene -LRB- SNAI1P -RRB- .
11162080	0	SNAI1	34,39	SNAIL	27,32	SNAI1	SNAIL	6615	6615	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the Human SNAIL -LRB- SNAI1 -RRB- gene .
22514743	0	SNAI1	40,45	miRNA-203	30,39	SNAI1	miRNA-203	6615	406986	Gene	Gene	loop|compound|START_ENTITY loop|amod|END_ENTITY	A novel network integrating a miRNA-203 / SNAI1 feedback loop which regulates epithelial to mesenchymal transition .
27029493	0	SNAI2	48,53	Lysyl_Oxidase	0,13	SNAI2	Lysyl Oxidase	6591	4015	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Lysyl_Oxidase -LRB- LOX -RRB- transcriptionally regulates SNAI2 expression and TIMP4 secretion in human cancers .
12955764	0	SNAI2	22,27	SLUG	16,20	SNAI2	SLUG	6591	6591	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Deletion of the SLUG -LRB- SNAI2 -RRB- gene results in human piebaldism .
21785273	0	SNAI2	6,11	Slug	0,4	SNAI2	Slug	6591	6591	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Slug -LRB- SNAI2 -RRB- expression in oral SCC cells results in altered cell-cell adhesion and increased motility .
23447531	0	SNAI2	80,85	miR-203	119,126	SNAI2	miR-203	6591	406986	Gene	Gene	represses|nsubj|START_ENTITY represses|xcomp|END_ENTITY	Signaling between transforming_growth_factor_b -LRB- TGF-b -RRB- and transcription factor SNAI2 represses expression of microRNA miR-203 to promote epithelial-mesenchymal transition and tumor metastasis .
14507651	0	SNAIL	69,74	E-cadherin	37,47	SNAIL	E-cadherin	6615	999	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian_carcinoma cells .
16203744	0	SNAIL	48,53	E-cadherin	0,10	SNAIL	E-cadherin	6615	999	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	E-cadherin and vitamin_D_receptor regulation by SNAIL and ZEB1 in colon_cancer : clinicopathological correlations .
27044634	0	SNAIL	0,5	HIF-1a	53,59	SNAIL	HIF-1a	6615	3091	Gene	Gene	gene|compound|START_ENTITY inhibited|nsubj|gene inhibited|nmod|END_ENTITY	SNAIL gene inhibited by hypoxia-inducible_factor_1a -LRB- HIF-1a -RRB- in epithelial_ovarian_cancer .
10585766	0	SNAIL	71,76	SNAI1	83,88	SNAIL	SNAI1	6615	6615	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization , expression , and chromosome location of the human SNAIL gene -LRB- SNAI1 -RRB- and a related processed pseudogene -LRB- SNAI1P -RRB- .
11162080	0	SNAIL	27,32	SNAI1	34,39	SNAIL	SNAI1	6615	6615	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the Human SNAIL -LRB- SNAI1 -RRB- gene .
21640118	0	SNAIL	0,5	interleukin-8	16,29	SNAIL	interleukin-8	6615	3576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	SNAIL regulates interleukin-8 expression , stem cell-like activity , and tumorigenicity of human colorectal_carcinoma cells .
15322538	0	SNAIL	25,30	vitamin_D_receptor	41,59	SNAIL	vitamin D receptor	6615	7421	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	The transcription factor SNAIL represses vitamin_D_receptor expression and responsiveness in human colon_cancer .
15770204	0	SNAIL	0,5	vitamin_D_receptor	9,27	SNAIL	vitamin D receptor	6615	7421	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	SNAIL vs vitamin_D_receptor expression in colon_cancer : therapeutics implications .
21846773	0	SNAIL1	14,20	DNMT1	48,53	SNAIL1	DNMT1	6615	1786	Gene	Gene	Regulation|nmod|START_ENTITY function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context .
23644467	0	SNAIL1	61,67	discoidin_domain_receptor_2	22,49	SNAIL1	discoidin domain receptor 2	6615	4921	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	The collagen receptor discoidin_domain_receptor_2 stabilizes SNAIL1 to facilitate breast_cancer metastasis .
23613522	0	SNAP-23	30,37	IkB	0,3	SNAP-23	IkB	20619(Tax:10090)	18036(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	IkB kinase phosphorylation of SNAP-23 controls platelet secretion .
10036234	0	SNAP-23	31,38	Syntaxin_11	0,11	SNAP-23	Syntaxin 11	8773	8676	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Syntaxin_11 is associated with SNAP-23 on late endosomes and the trans-Golgi network .
17575076	0	SNAP-23	40,47	annexin_A2	53,63	SNAP-23	annexin A2	8773	302	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Physical and functional interactions of SNAP-23 with annexin_A2 .
9639508	0	SNAP-23	52,59	synaptosomal-associated_protein-23_kD	13,50	SNAP-23	synaptosomal-associated protein-23 kD	8773	8773	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of synaptosomal-associated_protein-23_kD -LRB- SNAP-23 -RRB- by various cytokines .
12209004	0	SNAP-23	42,49	syntaxin_1A	50,61	SNAP-23	syntaxin 1A	8773	6804	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	CFTR chloride channels are regulated by a SNAP-23 / syntaxin_1A complex .
11058092	0	SNAP-24	0,7	SNAP-25	22,29	SNAP-24	SNAP-25	41193(Tax:7227)	3355084(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	SNAP-24 , a Drosophila SNAP-25 homologue on granule membranes , is a putative mediator of secretion and granule-granule fusion in salivary glands .
10825299	0	SNAP-25	19,26	Hrs	0,3	SNAP-25	Hrs	25012(Tax:10116)	56084(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Hrs interacts with SNAP-25 and regulates Ca -LRB- 2 + -RRB- - dependent exocytosis .
11058092	0	SNAP-25	22,29	SNAP-24	0,7	SNAP-25	SNAP-24	3355084(Tax:7227)	41193(Tax:7227)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	SNAP-24 , a Drosophila SNAP-25 homologue on granule membranes , is a putative mediator of secretion and granule-granule fusion in salivary glands .
18194215	0	SNAP-25	22,29	SP1	0,3	SNAP-25	SP1	6616	6667	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SP1 regulates a human SNAP-25 gene expression .
9665586	0	SNAP-25	0,7	nerve_growth_factor	85,104	SNAP-25	nerve growth factor	6616	4803	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|release release|nmod|END_ENTITY	SNAP-25 and syntaxin , but not synaptobrevin_2 , cooperate in the regulated release of nerve_growth_factor .
19482079	0	SNAP-25	55,62	synaptosomal-associated_protein_25	19,53	SNAP-25	synaptosomal-associated protein 25	25012(Tax:10116)	25012(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Gene expression of synaptosomal-associated_protein_25 -LRB- SNAP-25 -RRB- in the prefrontal cortex of the spontaneously hypertensive rat -LRB- SHR -RRB- .
22311984	0	SNAP-25	112,119	synaptosomal-associated_protein_25	76,110	SNAP-25	synaptosomal-associated protein 25	25012(Tax:10116)	25012(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Phospholipase_C-related_but_catalytically_inactive_protein -LRB- PRIP -RRB- modulates synaptosomal-associated_protein_25 -LRB- SNAP-25 -RRB- phosphorylation and exocytosis .
20333500	0	SNAP-25	44,51	synaptosomal_protein	22,42	SNAP-25	synaptosomal protein	6616	6616	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association between a synaptosomal_protein -LRB- SNAP-25 -RRB- gene polymorphism and verbal memory and attention in patients with endogenous psychoses and mentally healthy subjects .
12082176	0	SNAP-25	74,81	syntaxin_6	60,70	SNAP-25	syntaxin 6	6616	10228	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Three-dimensional structure of the amino-terminal domain of syntaxin_6 , a SNAP-25 C homolog .
19170188	0	SNAP-29	18,25	Rab3A	52,57	SNAP-29	Rab3A	9342	5864	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The SNARE protein SNAP-29 interacts with the GTPase Rab3A : Implications for membrane trafficking in myelinating glia .
10713150	0	SNAP23	8,14	GLUT4	51,56	SNAP23	GLUT4	8773	6517	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|translocation translocation|nmod|END_ENTITY	Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes .
18381601	0	SNAP25	14,20	Tat	41,44	SNAP25	Tat	6616	155871(Tax:11676)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a .
20826818	0	SNARE	100,105	CAPS	22,26	SNARE	CAPS	100170220	8618	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Novel interactions of CAPS -LRB- Ca2 + - dependent_activator_protein_for_secretion -RRB- with the three neuronal SNARE proteins required for vesicle fusion .
22797916	0	SNARE-associated_protein_Snapin	58,89	Atg14L	39,45	SNARE-associated protein Snapin	Atg14L	23557	22863	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated_protein_Snapin to coordinate endocytic trafficking .
17101137	0	SNARE_associated_protein_snapin	52,83	Casein_kinase_1_delta	0,21	SNARE associated protein snapin	Casein kinase 1 delta	23557	1453	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Casein_kinase_1_delta -LRB- CK1delta -RRB- interacts with the SNARE_associated_protein_snapin .
16629640	0	SNAT2	61,66	SNAT5	82,87	SNAT2	SNAT5	54407	92745	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Evidence for allosteric regulation of pH-sensitive System A -LRB- SNAT2 -RRB- and System_N -LRB- SNAT5 -RRB- amino_acid transporter activity involving a conserved histidine residue .
16629640	0	SNAT5	82,87	SNAT2	61,66	SNAT5	SNAT2	92745	54407	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Evidence for allosteric regulation of pH-sensitive System A -LRB- SNAT2 -RRB- and System_N -LRB- SNAT5 -RRB- amino_acid transporter activity involving a conserved histidine residue .
21511949	0	SNAT7	27,32	SLC38A7	18,25	SNAT7	SLC38A7	55238	55238	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of SLC38A7 -LRB- SNAT7 -RRB- protein as a glutamine transporter expressed in neurons .
11751692	0	SNCA	90,94	alpha-synuclein	68,83	SNCA	alpha-synuclein	6622	6622	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene -LRB- SNCA -RRB- on transcription in a cell culture luciferase reporter system .
20443127	0	SNCA	110,114	alpha-synuclein	88,103	SNCA	alpha-synuclein	6622	6622	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the alpha-synuclein gene -LRB- SNCA -RRB- .
11016747	0	SNCG	48,52	synuclein_gamma	31,46	SNCG	synuclein gamma	6623	6623	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transcriptional suppression of synuclein_gamma -LRB- SNCG -RRB- expression in human breast_cancer cells by the growth inhibitory cytokine oncostatin_M .
19808805	0	SND1	28,32	MYB83	0,5	SND1	MYB83	840171(Tax:3702)	819997(Tax:3702)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MYB83 is a direct target of SND1 and acts redundantly with MYB46 in the regulation of secondary cell wall biosynthesis in Arabidopsis .
25596283	0	SND1	0,4	Smurf1	46,52	SND1	Smurf1	27044	57154	Gene	Gene	Downstream|compound|START_ENTITY Downstream|nmod|END_ENTITY	SND1 Acts Downstream of TGFb1 and Upstream of Smurf1 to Promote Breast_Cancer_Metastasis .
25596283	0	SND1	0,4	TGFb1	24,29	SND1	AEG-1	27044	92140	Gene	Gene	Downstream|compound|START_ENTITY Downstream|nmod|END_ENTITY	SND1 Acts Downstream of TGFb1 and Upstream of Smurf1 to Promote Breast_Cancer_Metastasis .
22133261	0	SND2	0,4	NAC_transcription_factor	8,32	SND2	NAC transcription factor	828968(Tax:3702)	828144(Tax:3702)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	SND2 , a NAC_transcription_factor gene , regulates genes involved in secondary cell wall development in Arabidopsis fibres and increases fibre cell area in Eucalyptus .
21639856	0	SNEV	56,60	Exo70	0,5	SNEV	Exo70	27339	23265	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Exo70 , a subunit of the exocyst complex , interacts with SNEV -LRB- hPrp19/hPso4 -RRB- and is involved in pre-mRNA splicing .
14500758	0	SNF2-related_CBP_activator_protein	0,34	CARM-1	151,157	SNF2-related CBP activator protein	CARM-1	10847	10498	Gene	Gene	START_ENTITY|nmod|interactions interactions|nmod|END_ENTITY	SNF2-related_CBP_activator_protein -LRB- SRCAP -RRB- functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1 .
11581372	0	SNF2-related_CBP_activator_protein	50,84	DNA_binding_protein	11,30	SNF2-related CBP activator protein	DNA binding protein	10847	7335	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Adenovirus DNA_binding_protein interacts with the SNF2-related_CBP_activator_protein -LRB- SrCap -RRB- and inhibits SrCap-mediated transcription .
23911928	0	SNF2H	15,20	SIRT6	0,5	SNF2H	SIRT6	8467	51548	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	SIRT6 recruits SNF2H to DNA break sites , preventing genomic instability through chromatin remodeling .
16740656	0	SNF2L	29,34	steroidogenic_acute_regulatory_protein	45,83	SNF2L	steroidogenic acute regulatory protein	6594	6770	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The imitation_switch protein SNF2L regulates steroidogenic_acute_regulatory_protein expression during terminal differentiation of ovarian granulosa cells .
21519849	0	SNF2h	18,23	Vpr	86,89	SNF2h	Vpr	8467	155807(Tax:11676)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of SNF2h , a chromatin-remodeling factor , as a novel binding protein of Vpr of human_immunodeficiency_virus_type_1 .
20473326	0	SNF5	0,4	eIF4E	114,119	SNF5	eIF4E	20587(Tax:10090)	13684(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	SNF5 , a core component of the SWI/SNF complex , is necessary for p53 expression and cell survival , in part through eIF4E .
23171048	0	SNF8	0,4	TRPC6	55,60	SNF8	TRPC6	11267	7225	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SNF8 , a member of the ESCRT-II complex , interacts with TRPC6 and enhances its channel activity .
11567019	0	SNIP1	0,5	NF-kappa_B	15,25	SNIP1	NF-kappa B	79753	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	SNIP1 inhibits NF-kappa_B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators .
18848520	0	SNM1A	0,5	ATM	25,28	SNM1A	ATM	9937	472	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint .
25505141	0	SNM1A	19,24	CSB	0,3	SNM1A	CSB	9937	1443	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CSB interacts with SNM1A and promotes DNA interstrand crosslink processing .
20479256	0	SNM1B	20,25	Apollo	12,18	SNM1B	Apollo	64858	64858	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Function of Apollo -LRB- SNM1B -RRB- at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson_syndrome .
20588305	0	SNORD116	82,90	snoRNA	99,105	SNORD116	snoRNA	692236	85391	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Paternally inherited microdeletion at 15q11 .2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader-Willi_syndrome .
9767597	0	SNQ2	160,164	YRR1	11,15	SNQ2	YRR1	851574(Tax:4932)	854333(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Yeast gene YRR1 , which is required for resistance to 4-nitroquinoline_N-oxide , mediates transcriptional activation of the multidrug resistance transporter gene SNQ2 .
15454538	0	SNR1	0,4	Brahma	76,82	SNR1	Brahma	40657(Tax:7227)	39744(Tax:7227)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|functions functions|nmod|END_ENTITY	SNR1 -LRB- INI1/SNF5 -RRB- mediates important cell growth functions of the Drosophila Brahma -LRB- SWI/SNF -RRB- chromatin remodeling complex .
16671894	0	SNR1	69,73	dDYRK2	0,6	SNR1	dDYRK2	40657(Tax:7227)	34831(Tax:7227)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX .
8821886	0	SNRPN	135,140	IGF2	69,73	SNRPN	IGF2	6638	3481	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Maintenance of imprinting of the insulin-like growth factor II gene -LRB- IGF2 -RRB- and the small_nuclear_ribonucleoprotein_polypeptide_N gene -LRB- SNRPN -RRB- in the human uterus and leiomyoma .
8780727	0	SNT	44,47	Suc1-associated_neurotrophic_factor_target	0,42	SNT	Suc1-associated neurotrophic factor target	10818	10818	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Suc1-associated_neurotrophic_factor_target -LRB- SNT -RRB- protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 .
15485655	0	SNT-2	0,5	ERK2	21,25	SNT-2	ERK2	10817	5594	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation .
24434436	0	SNTA1	8,13	Rac1	17,21	SNTA1	Rac1	6640	5879	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Role of SNTA1 in Rac1 activation , modulation of ROS generation , and migratory potential of human breast_cancer cells .
15707587	0	SNURF	31,36	SUMO-1	0,6	SNURF	SUMO-1	8926	7341	Gene	Gene	association|nmod|START_ENTITY promotes|dobj|association promotes|nsubj|END_ENTITY	SUMO-1 promotes association of SNURF -LRB- RNF4 -RRB- with PML nuclear bodies .
25825439	0	SNX17	0,5	TCR	46,49	SNX17	TCR	9784	6962	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	SNX17 Affects T Cell Activation by Regulating TCR and Integrin Recycling .
21266196	0	SNX25	0,5	TGF-b	16,21	SNX25	TGF-b	102141(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SNX25 regulates TGF-b signaling by enhancing the receptor degradation .
24003235	0	SNX26	0,5	Cdc42	39,44	SNX26	Cdc42	115703	998	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	SNX26 , a GTPase-activating protein for Cdc42 , interacts with PSD-95 protein and is involved in activity-dependent dendritic spine formation in mature neurons .
18596235	0	SNX5	36,40	DOCK180	19,26	SNX5	DOCK180	27131	1793	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|domain domain|nmod|END_ENTITY	The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose_6-phosphate receptor transport .
19935774	0	SNX6	23,27	p150	52,56	SNX6	p150	58533	10036	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The retromer component SNX6 interacts with dynactin p150 -LRB- Glued -RRB- and mediates endosome-to-TGN transport .
24362679	0	SNX8	44,48	sorting_nexin_8	27,42	SNX8	sorting nexin 8	29886	29886	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of neuronal sorting_nexin_8 -LRB- SNX8 -RRB- exacerbates abnormal cholesterol levels .
27033324	0	SOAT	111,115	SLC10A6	117,124	SOAT	SLC10A6	345274	345274	Gene	Gene	inhibitors|nmod|START_ENTITY Identification|nmod|inhibitors Identification|appos|END_ENTITY	Identification of novel inhibitors of the steroid_sulfate carrier ` sodium-dependent_organic_anion_transporter ' SOAT -LRB- SLC10A6 -RRB- by pharmacophore modelling .
22902690	0	SOC1	27,31	AGL24	0,5	SOC1	AGL24	819174(Tax:3702)	828556(Tax:3702)	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	AGL24 acts in concert with SOC1 and FUL during Arabidopsis floral transition .
17609438	0	SOC3	50,54	growth_hormone	59,73	SOC3	growth hormone	9021	2688	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOC3 -RRB- by growth_hormone in pro-B cells .
17609438	0	SOC3	50,54	suppressor_of_cytokine_signaling_3	14,48	SOC3	suppressor of cytokine signaling 3	9021	9021	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOC3 -RRB- by growth_hormone in pro-B cells .
16551679	0	SOCS	15,19	IL-21	0,5	SOCS	IL-21	1154	59067	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells .
12713738	0	SOCS	21,25	NF-kappaB	29,38	SOCS	NF-kappaB	12700(Tax:10090)	18033(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Regulatory effect of SOCS on NF-kappaB activity in murine monocytes/macrophages .
18590740	0	SOCS	4,8	SOCS3	23,28	SOCS	SOCS3	1154	9021	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The SOCS box domain of SOCS3 : structure and interaction with the elonginBC-cullin5 ubiquitin ligase .
12101419	0	SOCS	28,32	SOCS36E	0,7	SOCS	SOCS36E	35085(Tax:7227)	35085(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	SOCS36E , a novel Drosophila SOCS protein , suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc .
25849377	0	SOCS	34,38	Suppressor_of_Cytokine_Signaling	0,32	SOCS	Suppressor of Cytokine Signaling	1154	1154	Gene	Gene	Genes|appos|START_ENTITY Genes|amod|END_ENTITY	Suppressor_of_Cytokine_Signaling -LRB- SOCS -RRB- Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical_Cancer Cells .
23296734	0	SOCS	47,51	Suppressor_of_Cytokine_Signalling	12,45	SOCS	Suppressor of Cytokine Signalling	12700(Tax:10090)	12700(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of Suppressor_of_Cytokine_Signalling -LRB- SOCS -RRB- gene expression by real-time quantitative PCR .
15491991	0	SOCS	34,38	Suppressor_of_cytokine_signaling	0,32	SOCS	Suppressor of cytokine signaling	1154	1154	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Suppressor_of_cytokine_signaling -LRB- SOCS -RRB- proteins indirectly regulate toll-like receptor signaling in innate immune cells .
26085211	0	SOCS	142,146	suppressor_of_cytokine_signaling	108,140	SOCS	suppressor of cytokine signaling	12700(Tax:10090)	12700(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Kinase inhibition , competitive binding and proteasomal degradation : resolving the molecular function of the suppressor_of_cytokine_signaling -LRB- SOCS -RRB- proteins .
16571771	0	SOCS-1	17,23	CD40	45,49	SOCS-1	CD40	8651	958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia .
14634100	0	SOCS-1	22,28	IL-4	0,4	SOCS-1	IL-4	8651	3565	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site .
9789053	0	SOCS-1	32,38	JAB	39,42	SOCS-1	JAB	8651	8651	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Three distinct domains of SSI-1 / SOCS-1 / JAB protein are required for its suppression of interleukin_6 signaling .
9789053	0	SOCS-1	32,38	SSI-1	26,31	SOCS-1	SSI-1	8651	8651	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Three distinct domains of SSI-1 / SOCS-1 / JAB protein are required for its suppression of interleukin_6 signaling .
27064016	0	SOCS-1	70,76	STAT3	21,26	SOCS-1	STAT3	8651	6774	Gene	Gene	induction|nmod|START_ENTITY signaling|nmod|induction END_ENTITY|acl|signaling	Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1 : Role in apoptosis induction and radiosensitization in head_and_neck_tumor cells .
10485906	0	SOCS-1	88,94	STAT6	34,39	SOCS-1	STAT6	8651	6778	Gene	Gene	expression|compound|START_ENTITY inducing|dobj|expression inhibit|advcl|inducing inhibit|dobj|activation activation|nmod|END_ENTITY	Interferons inhibit activation of STAT6 by interleukin_4 in human monocytes by inducing SOCS-1 gene expression .
18536936	0	SOCS-1	94,100	Stat6	18,23	SOCS-1	Stat6	8651	6778	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|activities activities|amod|END_ENTITY	Differential IL-4 / Stat6 activities correlate with differential expression of regulatory genes SOCS-1 , SHP-1 , and PP2A in colon_cancer cells .
19551406	0	SOCS-1	76,82	Stat6	53,58	SOCS-1	Stat6	8651	6778	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon_cancer cells .
14733929	0	SOCS-1	18,24	eotaxin	51,58	SOCS-1	eotaxin	12703(Tax:10090)	20292(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	IFN-gamma-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-alpha .
24091729	0	SOCS-1	16,22	miR-29b	0,7	SOCS-1	miR-29b	8651	407024	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple_myeloma and endothelial cells .
23134344	0	SOCS-1	161,167	suppressor_of_cytokine_signaling	127,159	SOCS-1	suppressor of cytokine signaling	8651	1154	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Overexpression of signal transducer and activator of transcription -LRB- STAT-3 and STAT-5 -RRB- transcription factors and alteration of suppressor_of_cytokine_signaling -LRB- SOCS-1 -RRB- protein in prostate_cancer .
21385099	0	SOCS-1	75,81	suppressor_of_cytokine_signaling-1	39,73	SOCS-1	suppressor of cytokine signaling-1	8651	8651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Methylation-mediated gene silencing of suppressor_of_cytokine_signaling-1 -LRB- SOCS-1 -RRB- gene in esophageal_squamous_cell_carcinoma patients of Kashmir valley .
12865927	0	SOCS-1	61,67	suppressor_of_cytokine_signalling-1	24,59	SOCS-1	suppressor of cytokine signalling-1	8651	8651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aberrant methylation of suppressor_of_cytokine_signalling-1 -LRB- SOCS-1 -RRB- gene in pancreatic_ductal_neoplasms .
17030374	0	SOCS-1	41,47	suppressor_of_cytokine_signalling-1	4,39	SOCS-1	suppressor of cytokine signalling-1	8651	8651	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The suppressor_of_cytokine_signalling-1 -LRB- SOCS-1 -RRB- gene is overexpressed in Philadelphia chromosome negative chronic_myeloproliferative_disorders .
10433229	0	SOCS-2	29,35	Growth_hormone	0,14	SOCS-2	Growth hormone	84607(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Growth_hormone regulation of SOCS-2 , SOCS-3 , and CIS messenger ribonucleic acid expression in the rat .
10403376	0	SOCS-2	50,56	growth_hormone	61,75	SOCS-2	growth hormone	8835	2688	Gene	Gene	effects|appos|START_ENTITY effects|nmod|transduction transduction|amod|END_ENTITY	Dual effects of suppressor_of_cytokine_signaling -LRB- SOCS-2 -RRB- on growth_hormone signal transduction .
12208853	0	SOCS-2	25,31	growth_hormone	79,93	SOCS-2	growth hormone	216233(Tax:10090)	14599(Tax:10090)	Gene	Gene	evidence|dep|START_ENTITY act|nsubj|evidence act|nmod|enhancer enhancer|nmod|signaling signaling|amod|END_ENTITY	Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth_hormone signaling .
10403376	0	SOCS-2	50,56	suppressor_of_cytokine_signaling	16,48	SOCS-2	suppressor of cytokine signaling	8835	8835	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Dual effects of suppressor_of_cytokine_signaling -LRB- SOCS-2 -RRB- on growth_hormone signal transduction .
19470084	0	SOCS-2	65,71	suppressor_of_cytokine_signalling_2	28,63	SOCS-2	suppressor of cytokine signalling 2	216233(Tax:10090)	216233(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Heterogeneous expression of suppressor_of_cytokine_signalling_2 -LRB- SOCS-2 -RRB- in liver tissue .
24593195	0	SOCS-3	81,87	CXC-chemokine_receptor_CXCR2_and_suppressor_of_cytokine_signaling-3	12,79	SOCS-3	CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3	9021	9021	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of CXC-chemokine_receptor_CXCR2_and_suppressor_of_cytokine_signaling-3 -LRB- SOCS-3 -RRB- in renal_cell_carcinoma .
18687693	0	SOCS-3	0,6	DP-1	98,102	SOCS-3	DP-1	9021	7027	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	SOCS-3 inhibits E2F/DP -1 transcriptional activity and cell cycle progression via interaction with DP-1 .
16055089	0	SOCS-3	34,40	Estrogen_receptor-alpha	0,23	SOCS-3	Estrogen receptor-alpha	9021	2099	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Estrogen_receptor-alpha regulates SOCS-3 expression in human breast_cancer cells .
9430658	0	SOCS-3	73,79	Growth_hormone	0,14	SOCS-3	Growth hormone	12702(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Growth_hormone preferentially induces the rapid , transient expression of SOCS-3 , a novel inhibitor of cytokine receptor signaling .
11705792	0	SOCS-3	56,62	STAT-3	27,33	SOCS-3	STAT-3	89829(Tax:10116)	25125(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Constitutive activation of STAT-3 and downregulation of SOCS-3 expression induced by adrenalectomy .
10998044	0	SOCS-3	36,42	growth_hormone	66,80	SOCS-3	growth hormone	89829(Tax:10116)	81668(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|hepatocytes hepatocytes|nmod|analysis analysis|amod|END_ENTITY	Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth_hormone , interleukin-6 and glucocorticoids mRNA analysis and promoter characterization .
12734778	0	SOCS-3	0,6	growth_hormone	78,92	SOCS-3	growth hormone	89829(Tax:10116)	81668(Tax:10116)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|downregulation downregulation|nmod|effects effects|nmod|END_ENTITY	SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth_hormone in rat adipocytes by inhibition of Jak2/IRS -1 signaling .
19408656	0	SOCS-3	51,57	leptin	27,33	leptin	leptin	25608(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of rat recombinant leptin on expression of SOCS-3 in mature adipocytes -RSB- .
18237746	0	SOCS-3	70,76	suppressor_of_cytokine_signaling-3	34,68	SOCS-3	suppressor of cytokine signaling-3	9021	9021	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of the suppressor_of_cytokine_signaling-3 -LRB- SOCS-3 -RRB- gene via STAT3 is increased in F9 REX1 -LRB- ZFP-42 -RRB- knockout teratocarcinoma stem cells relative to wild-type cells .
12052866	0	SOCS-6	0,6	insulin_receptor_substrate_4	16,44	SOCS-6	insulin receptor substrate 4	54607(Tax:10090)	16370(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	SOCS-6 binds to insulin_receptor_substrate_4 , and mice lacking the SOCS-6 gene exhibit mild growth_retardation .
20007709	0	SOCS-6	0,6	p56lck	64,70	SOCS-6	p56lck	9306	3932	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation .
18606672	0	SOCS1	0,5	CCR7	16,20	SOCS1	CCR7	12703(Tax:10090)	12775(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SOCS1 regulates CCR7 expression and migration of CD4 + T cells into peripheral tissues .
24018353	0	SOCS1	42,47	Gfi-1	0,5	SOCS1	Gfi-1	8651	2672	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Gfi-1 is the transcriptional repressor of SOCS1 in acute_myeloid_leukemia cells .
21703184	0	SOCS1	0,5	HGF	48,51	SOCS1	HGF	12703(Tax:10090)	15234(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|END_ENTITY	SOCS1 controls liver_regeneration by regulating HGF signaling in hepatocytes .
17888401	0	SOCS1	0,5	STAT3	55,60	SOCS1	STAT3	8651	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast_cancer cells .
23817566	0	SOCS1	130,135	STAT3	98,103	SOCS1	STAT3	8651	6774	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of miR-155 affects pancreatic_cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1 .
19576891	0	SOCS1	46,51	Wallerian_degeneration	65,87	SOCS1	Wallerian degeneration	12703(Tax:10090)	22406(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression and potential role of SOCS1 and SOCS3 in Wallerian_degeneration in injured peripheral nerve .
12670405	0	SOCS1	45,50	cytokine_receptor	14,31	SOCS1	cytokine receptor	8651	8809	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of cytokine_receptor signaling by SOCS1 .
22771905	0	SOCS1	78,83	miR-155	21,28	SOCS1	miR-155	8651	406947	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Interferon-b-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF .
23621248	0	SOCS1	65,70	miR-19a	0,7	SOCS1	miR-19a	8651	406979	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-19a promotes cell growth and tumorigenesis through targeting SOCS1 in gastric_cancer .
26990535	0	SOCS1	29,34	miR-203	0,7	SOCS1	miR-203	8651	406986	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|dep|regulate	miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential_thrombocythemia .
24351865	0	SOCS1	53,58	microRNA-155	32,44	SOCS1	microRNA-155	8651	406947	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Rheumatoid_arthritis-associated microRNA-155 targets SOCS1 and upregulates TNF-a and IL-1b in PBMCs .
26620207	0	SOCS1	92,97	microRNA-155_and_suppressor_of_cytokine_signaling_1	39,90	SOCS1	microRNA-155 and suppressor of cytokine signaling 1	8651	406947;8651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Simultaneously increased expression of microRNA-155_and_suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- gene in the peripheral blood mononuclear cells of patients with primary Sj gren 's syndrome .
24997329	0	SOCS1	55,60	suppressor_of_cytokine_signaling_1	19,53	SOCS1	suppressor of cytokine signaling 1	8651	8651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- gene polymorphisms with acute_coronary_syndrome in Mexican patients .
25701091	0	SOCS1	50,55	suppressor_of_cytokine_signaling_1	14,48	SOCS1	suppressor of cytokine signaling 1	8651	8651	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- gene dramatically increases in relapsing-remitting multiple_sclerosis .
25833299	0	SOCS2	53,58	GH	32,34	SOCS2	GH	216233(Tax:10090)	14599(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1 .
17469064	0	SOCS2	80,85	suppressor_of_cytokine_signaling-2	44,78	SOCS2	suppressor of cytokine signaling-2	100855737	100855737	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of variation in the canine suppressor_of_cytokine_signaling-2 -LRB- SOCS2 -RRB- gene .
16406727	0	SOCS2	90,95	suppressor_of_cytokine_signaling_2	54,88	SOCS2	suppressor of cytokine signaling 2	8835	8835	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of single-nucleotide polymorphisms in the suppressor_of_cytokine_signaling_2 -LRB- SOCS2 -RRB- gene with type_2_diabetes in the Japanese .
18055217	0	SOCS3	0,5	AP-1	17,21	SOCS3	AP-1	9021	3726	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|compound|END_ENTITY	SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun_N-terminal_kinase .
22613986	0	SOCS3	79,84	Angiotensin_II	0,14	SOCS3	Angiotensin II	9021	183	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces angiogenic factors production partly via AT1/JAK2/STAT3 / SOCS3 signaling pathway in MHCC97H cells .
23686487	0	SOCS3	0,5	BAFF	16,20	SOCS3	BAFF	9021	10673	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SOCS3 regulates BAFF in human enterocytes under ribosomal stress .
19255186	0	SOCS3	15,20	CD11c	38,43	SOCS3	CD11c	12702(Tax:10090)	16411(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Involvement of SOCS3 in regulation of CD11c + dendritic cell-derived osteoclastogenesis and severe alveolar_bone_loss .
17621372	0	SOCS3	10,15	CD25	34,38	SOCS3	CD25	9021	3559	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
17621372	0	SOCS3	10,15	CD4	30,33	SOCS3	CD4	9021	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
23038263	0	SOCS3	97,102	Ciliary_neurotrophic_factor	0,27	SOCS3	Ciliary neurotrophic factor	12702(Tax:10090)	12803(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Ciliary_neurotrophic_factor protects mice against streptozotocin-induced type 1 diabetes through SOCS3 : the role of STAT1/STAT3 ratio in b-cell death .
17621372	0	SOCS3	10,15	FoxP3	39,44	SOCS3	FoxP3	9021	50943	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Deficient SOCS3 expression in CD4 + CD25 + FoxP3 + regulatory T cells and SOCS3-mediated suppression of Treg function .
16199887	0	SOCS3	74,79	IL-3	43,47	SOCS3	IL-3	12702(Tax:10090)	16187(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY signaling|nmod|degradation END_ENTITY|acl|signaling	SOCS2 can enhance interleukin-2 -LRB- IL-2 -RRB- and IL-3 signaling by accelerating SOCS3 degradation .
12754505	0	SOCS3	0,5	IL-6	27,31	SOCS3	IL-6	12702(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SOCS3 negatively regulates IL-6 signaling in vivo .
23238769	0	SOCS3	46,51	IL-6	74,78	SOCS3	IL-6	12702(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY decreasing|dobj|expression decreasing|advcl|enhance enhance|dobj|signals signals|compound|END_ENTITY	A20 promotes liver_regeneration by decreasing SOCS3 expression to enhance IL-6 / STAT3 proliferative signals .
17668875	0	SOCS3	36,41	Insulin	103,110	SOCS3	Insulin	9021	3630	Gene	Gene	expression|appos|START_ENTITY expression|dep|resistance resistance|compound|END_ENTITY	Suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- expression and hepatitis_C virus-related chronic hepatitis : Insulin resistance and response to antiviral therapy .
16497512	0	SOCS3	0,5	LIF	27,30	SOCS3	LIF	9021	3976	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SOCS3 negatively regulates LIF signaling in neural precursor cells .
15173187	0	SOCS3	24,29	Nck	49,52	SOCS3	Nck	12702(Tax:10090)	17973(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation .
18590740	0	SOCS3	23,28	SOCS	4,8	SOCS3	SOCS	9021	1154	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The SOCS box domain of SOCS3 : structure and interaction with the elonginBC-cullin5 ubiquitin ligase .
12392283	0	SOCS3	47,52	STAT3	74,79	SOCS3	STAT3	89829(Tax:10116)	25125(Tax:10116)	Gene	Gene	increases|nmod|START_ENTITY lead|nsubj|increases lead|nmod|decreases decreases|nmod|END_ENTITY	Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3 .
17028185	0	SOCS3	8,13	STAT3	39,44	SOCS3	STAT3	12702(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Loss|nmod|expression converts|nsubj|Loss converts|dobj|function function|compound|END_ENTITY	Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic .
19524687	0	SOCS3	15,20	STAT3	125,130	SOCS3	STAT3	9021	6774	Gene	Gene	Restoration|nmod|START_ENTITY suppresses|nsubj|Restoration suppresses|advcl|downregulating downregulating|nmod|END_ENTITY	Restoration of SOCS3 suppresses human lung_adenocarcinoma cell growth by downregulating activation of Erk1/2 , Akt apart from STAT3 .
20484656	0	SOCS3	20,25	STAT3	59,64	SOCS3	STAT3	9021	6774	Gene	Gene	expression|compound|START_ENTITY inhibits|nsubj|expression inhibits|dobj|phosphorylation phosphorylation|amod|IL-6-induced IL-6-induced|dep|END_ENTITY	IFN_gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells .
21354254	0	SOCS3	16,21	STAT3	34,39	SOCS3	STAT3	9021	6774	Gene	Gene	limiting|nsubj|START_ENTITY limiting|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Hypoxia-induced SOCS3 is limiting STAT3 phosphorylation and NF-kB activation in congenital_heart_disease .
21617181	0	SOCS3	118,123	STAT3	145,150	SOCS3	STAT3	12702(Tax:10090)	20848(Tax:10090)	Gene	Gene	levels|nummod|START_ENTITY reduces|dobj|levels reduces|advcl|inhibiting inhibiting|dobj|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-b / - -LRB- PPAR-b / - -RRB- ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes .
22575502	0	SOCS3	102,107	STAT3	127,132	SOCS3	STAT3	9021	6774	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|activation activation|compound|END_ENTITY	A novel pro-inflammatory mechanism of action of resistin in human endothelial cells : up-regulation of SOCS3 expression through STAT3 activation .
22929979	0	SOCS3	85,90	STAT3	58,63	SOCS3	STAT3	12702(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY up-regulation|nmod|expression END_ENTITY|nmod|up-regulation	Platelet_factor_4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma .
23027374	0	SOCS3	110,115	STAT3	41,46	SOCS3	STAT3	9021	6774	Gene	Gene	induction|nmod|START_ENTITY suppresses|nmod|induction suppresses|dobj|activation activation|compound|END_ENTITY	Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon_carcinoma cells through induction of SOCS3 .
23104276	0	SOCS3	29,34	STAT3	44,49	SOCS3	STAT3	9021	6774	Gene	Gene	increase|compound|START_ENTITY decreases|nmod|increase END_ENTITY|nsubj|decreases	Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression .
23226414	0	SOCS3	101,106	STAT3	19,24	SOCS3	STAT3	9021	6774	Gene	Gene	effect|nmod|START_ENTITY role|dep|effect role|nmod|END_ENTITY	Protective role of STAT3 in NMDA and glutamate-induced neuronal_death : negative regulatory effect of SOCS3 .
23238769	0	SOCS3	46,51	STAT3	79,84	SOCS3	STAT3	12702(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY decreasing|dobj|expression decreasing|advcl|enhance enhance|dobj|signals signals|compound|END_ENTITY	A20 promotes liver_regeneration by decreasing SOCS3 expression to enhance IL-6 / STAT3 proliferative signals .
23782265	0	SOCS3	73,78	STAT3	165,170	SOCS3	STAT3	9021	6774	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Flavanoids induce expression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- gene and suppress IL-6-activated signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in vascular endothelial cells .
24491408	0	SOCS3	92,97	STAT3	29,34	SOCS3	STAT3	9021	6774	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic_cancer cells by increasing SOCS3 expression .
25649351	0	SOCS3	0,5	STAT3	77,82	SOCS3	STAT3	9021	6774	Gene	Gene	Development|compound|START_ENTITY Development|dep|Involvement Involvement|nmod|Activation Activation|compound|END_ENTITY	SOCS3 Deficiency_in_Myeloid_Cells_Promotes_Tumor Development : Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells .
26707189	0	SOCS3	45,50	STAT3	54,59	SOCS3	STAT3	9021	6774	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast_cancer .
26847351	0	SOCS3	30,35	STAT3	53,58	SOCS3	STAT3	9021	6774	Gene	Gene	repression|nmod|START_ENTITY repression|parataxis|promotes promotes|nsubj|signaling signaling|compound|END_ENTITY	Transcriptional repression of SOCS3 mediated by IL-6 / STAT3 signaling via DNMT1 promotes pancreatic_cancer growth and metastasis .
17138568	0	SOCS3	0,5	Siglec_7	14,22	SOCS3	Siglec 7	9021	27036	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	SOCS3 targets Siglec_7 for proteasomal degradation and blocks Siglec_7-mediated responses .
17920684	0	SOCS3	0,5	Smad3	77,82	SOCS3	Smad3	9021	4088	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|signaling signaling|compound|END_ENTITY	SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1 / Smad3 signaling .
24799320	0	SOCS3	67,72	Stat3	33,38	SOCS3	Stat3	12702(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY pathway|nmod|expression pathway|amod|END_ENTITY	Platelet_factor_4 inhibits IL-17 / Stat3 pathway via upregulation of SOCS3 expression in melanoma .
17668875	0	SOCS3	36,41	Suppressor_of_cytokine_signaling_3	0,34	SOCS3	Suppressor of cytokine signaling 3	9021	9021	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- expression and hepatitis_C virus-related chronic hepatitis : Insulin resistance and response to antiviral therapy .
21360047	0	SOCS3	42,47	Suppressor_of_cytokine_signalling	0,33	SOCS3	Suppressor of cytokine signalling	9021	1154	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Suppressor_of_cytokine_signalling protein SOCS3 expression is increased at sites of acute_and_chronic_inflammation .
26384335	0	SOCS3	57,62	Suppressors_of_Cytokine_Signaling-3	20,55	SOCS3	Suppressors of Cytokine Signaling-3	9021	9021	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Effects of Reducing Suppressors_of_Cytokine_Signaling-3 -LRB- SOCS3 -RRB- Expression on Dendritic_Outgrowth_and_Demyelination after Spinal_Cord_Injury .
25939384	0	SOCS3	0,5	TBK1	40,44	SOCS3	TBK1	9021	29110	Gene	Gene	Degradation|compound|START_ENTITY Degradation|nmod|END_ENTITY	SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity .
17920684	0	SOCS3	0,5	TGF-beta1	67,76	SOCS3	TGF-beta1	9021	7040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|signaling signaling|compound|END_ENTITY	SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1 / Smad3 signaling .
26396267	0	SOCS3	0,5	VEGF	52,56	SOCS3	VEGF	12702(Tax:10090)	22339(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth .
20683642	0	SOCS3	0,5	insulin	15,22	SOCS3	insulin	9021	3630	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	SOCS3 inhibits insulin signaling in porcine primary adipocytes .
24711032	0	SOCS3	16,21	insulin	46,53	SOCS3	insulin	9021	3630	Gene	Gene	gene|compound|START_ENTITY Association|nmod|gene polymorphisms|nsubj|Association polymorphisms|nmod|resistance resistance|compound|END_ENTITY	-LSB- Association of SOCS3 gene polymorphisms with insulin resistance in Xinjiang Uygur population -RSB- .
25938827	0	SOCS3	49,54	insulin	103,110	SOCS3	insulin	9021	3630	Gene	Gene	polymorphism|nummod|START_ENTITY effect|nmod|polymorphism underlying|dobj|effect underlying|nmod|occurrence occurrence|nmod|resistance resistance|compound|END_ENTITY	-LSB- Study of the mechanism underlying the effect of SOCS3 rs4969170 A/G polymorphism on the occurrence of insulin resistance in chronic hepatitis_C patients -RSB- .
17408753	0	SOCS3	12,17	leukaemia_inhibitory_factor	32,59	SOCS3	leukaemia inhibitory factor	12702(Tax:10090)	16878(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of SOCS3 in modulating leukaemia_inhibitory_factor signalling during murine placental development .
18793717	0	SOCS3	0,5	p21	16,19	SOCS3	p21	9021	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage .
26797799	0	SOCS3	72,77	suppressor_of_cytokine_signaling_3	36,70	SOCS3	suppressor of cytokine signaling 3	9021	9021	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the anti-inflammatory suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- in human clear_cell_renal_cell_carcinoma .
16309496	0	SOCS3	59,64	suppressor_of_cytokine_signalling_3	22,57	SOCS3	suppressor of cytokine signalling 3	9021	9021	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- in severe atopic_dermatitis .
23782265	0	SOCS3	73,78	suppressor_of_cytokine_signalling_3	36,71	SOCS3	suppressor of cytokine signalling 3	9021	9021	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Flavanoids induce expression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- gene and suppress IL-6-activated signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in vascular endothelial cells .
12101419	0	SOCS36E	0,7	SOCS	28,32	SOCS36E	SOCS	35085(Tax:7227)	35085(Tax:7227)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	SOCS36E , a novel Drosophila SOCS protein , suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc .
26437444	0	SOCS4	84,89	MicroRNA-25	105,116	SOCS4	MicroRNA-25	122809	407014	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Interleukin-23 Facilitates Thyroid_Cancer Cell Migration and Invasion by Inhibiting SOCS4 Expression via MicroRNA-25 .
24801601	0	SOCS6	46,51	miR-17-5p	0,9	SOCS6	miR-17-5p	9306	406952	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-17-5p promotes proliferation by targeting SOCS6 in gastric_cancer cells .
17803907	0	SOCS7	106,111	NCK	90,93	SOCS7	NCK	30837	4690	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7 .
16314732	0	SOCS_3	52,58	Interferon-gamma	0,16	SOCS 3	Interferon-gamma	9021	3458	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interferon-gamma , but not interferon-alpha , induces SOCS_3 expression in human melanoma cell lines .
10601249	0	SOD	32,35	superoxide_dismutase	10,30	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	A gain of superoxide_dismutase -LRB- SOD -RRB- activity obtained with CCS , the copper_metallochaperone for SOD1 .
12624786	0	SOD	143,146	superoxide_dismutase	121,141	SOD	superoxide dismutase	6647	6647	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Immunohistochemical expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in human brain_tumors : relationships of iNOS to superoxide_dismutase -LRB- SOD -RRB- proteins -LRB- SOD1 and SOD2 -RRB- , Ki-67 antigen -LRB- MIB-1 -RRB- and p53 protein .
17395009	0	SOD	58,61	superoxide_dismutase	36,56	SOD	superoxide dismutase	6647	6647	Gene	Gene	Inactivation|appos|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation and nitration of human superoxide_dismutase -LRB- SOD -RRB- by fluxes of nitric_oxide and superoxide .
19049830	0	SOD	41,44	superoxide_dismutase	19,39	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Increased level of superoxide_dismutase -LRB- SOD -RRB- activity in larvae of Chironomus ramosus -LRB- Diptera : Chironomidae -RRB- subjected to ionizing radiation .
2130521	0	SOD	90,93	superoxide_dismutase	68,88	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	In vivo effect of free radical scavenger hepatoprotective agents on superoxide_dismutase -LRB- SOD -RRB- activity in patients .
21565362	0	SOD	36,39	superoxide_dismutase	14,34	SOD	superoxide dismutase	6647	6647	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Expression of superoxide_dismutase -LRB- SOD -RRB- genes from the copper-exposed polychaete , Neanthes succinea .
2625108	0	SOD	40,43	superoxide_dismutase	18,38	SOD	superoxide dismutase	6647	6647	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of superoxide_dismutase -LRB- SOD -RRB- in serum of cancer patients by microchemical luminescence -RSB- .
2733245	0	SOD	35,38	superoxide_dismutase	13,33	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Human plasma superoxide_dismutase -LRB- SOD -RRB- activity on reperfusion_injury with successful thrombolysis in acute myocardial_infarction .
3495372	0	SOD	63,66	superoxide_dismutase	41,61	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Relationship between melanin content and superoxide_dismutase -LRB- SOD -RRB- activity in the liver of various species of animals .
7921164	0	SOD	29,32	superoxide_dismutase	7,27	SOD	superoxide dismutase	6647	6647	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Normal superoxide_dismutase -LRB- SOD -RRB- gene in pregnancy-induced hypertension : is the decreased SOD activity a secondary phenomenon ?
8033747	0	SOD	73,76	superoxide_dismutase	51,71	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Study on correlation and clinical significance of superoxide_dismutase -LRB- SOD -RRB- activity and content in 102 patients with leukemia -RSB- .
8292974	0	SOD	82,85	superoxide_dismutase	60,80	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effect of the natural bioflavonoid antioxidant silymarin on superoxide_dismutase -LRB- SOD -RRB- activity and expression in vitro .
8372889	0	SOD	36,39	superoxide_dismutase	14,34	SOD	superoxide dismutase	6647	6647	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of superoxide_dismutase -LRB- SOD -RRB- in adenomyosis .
8920222	0	SOD	76,79	superoxide_dismutase	54,74	SOD	superoxide dismutase	6647	6647	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	An improved technique for the assay of red blood cell superoxide_dismutase -LRB- SOD -RRB- activity .
6883177	0	SOD-1	36,41	superoxide_dismutase	14,34	SOD-1	superoxide dismutase	397036(Tax:9823)	397036(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of superoxide_dismutase -LRB- SOD-1 -RRB- gene to chromosome No. 9 of domestic_pig .
11771762	0	SOD-1	61,66	superoxide_dismutase-1	37,59	SOD-1	superoxide dismutase-1	6647	6647	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Antioxidant proteins in fetal brain : superoxide_dismutase-1 -LRB- SOD-1 -RRB- protein is not overexpressed in fetal Down syndrome .
26600047	0	SOD1	7,11	APP	22,25	SOD1	APP	20655(Tax:10090)	11820(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS .
26327496	0	SOD1	51,55	Cu_Zn_superoxide_dismutase	23,49	SOD1	Cu Zn superoxide dismutase	6647	6647	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The IFN-b 1b effect on Cu_Zn_superoxide_dismutase -LRB- SOD1 -RRB- in peripheral mononuclear blood cells of relapsing-remitting multiple_sclerosis patients and in neuroblastoma SK-N-BE cells .
14718387	0	SOD1	39,43	DSCR1	0,5	SOD1	DSCR1	6647	1827	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	DSCR1 -LRB- Adapt78 -RRB- modulates expression of SOD1 .
16079151	0	SOD1	19,23	HoxB2	0,5	SOD1	HoxB2	20655(Tax:10090)	103889(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS .
19805546	0	SOD1	44,48	Hu_antigen_R	60,72	SOD1	Hu antigen R	20655(Tax:10090)	15568(Tax:10090)	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	Amyotrophic_lateral_sclerosis-linked mutant SOD1 sequesters Hu_antigen_R -LRB- HuR -RRB- and TIA-1-related_protein -LRB- TIAR -RRB- : implications for impaired post-transcriptional regulation of vascular_endothelial_growth_factor .
11556540	0	SOD1	132,136	Inducible_nitric_oxide_synthase	0,31	SOD1	Inducible nitric oxide synthase	20655(Tax:10090)	18126(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and nitrotyrosine immunoreactivity in the spinal cords of transgenic_mice with a G93A mutant SOD1 gene .
11176282	0	SOD1	0,4	NF-kappaB	20,29	SOD1	NF-kappaB	20655(Tax:10090)	18033(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	SOD1 down-regulates NF-kappaB and c-Myc expression in mice after transient focal cerebral_ischemia .
24236444	0	SOD1	29,33	PSK1	0,4	SOD1	PSK1	853568(Tax:4932)	851216(Tax:4932)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PSK1 regulates expression of SOD1 involved in oxidative stress tolerance in yeast .
25553268	0	SOD1	27,31	Superoxide_Dismutase	0,20	SOD1	Superoxide Dismutase	6647	6649	Gene	Gene	Gene|dep|START_ENTITY Gene|compound|END_ENTITY	Superoxide_Dismutase Gene -LRB- SOD1 , SOD2 , and SOD3 -RRB- Polymorphisms and Antituberculosis Drug-induced_Hepatitis .
22425406	0	SOD1	0,4	iNOS	49,53	SOD1	iNOS	6647	4843	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	SOD1 suppresses maternal hyperglycemia-increased iNOS expression and consequent nitrosative stress in diabetic_embryopathy .
16564582	0	SOD1	66,70	superoxide_dismutase	44,64	SOD1	superoxide dismutase	106057618	106057618	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Biomphalaria_glabrata cytosolic copper/zinc _ superoxide_dismutase -LRB- SOD1 -RRB- gene : association of SOD1 alleles with resistance/susceptibility to Schistosoma_mansoni .
22542607	0	SOD1	91,95	superoxide_dismutase	67,87	SOD1	superoxide dismutase	403559(Tax:9615)	6647	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Degenerative_myelopathy associated with a missense mutation in the superoxide_dismutase 1 -LRB- SOD1 -RRB- gene progresses to peripheral_neuropathy in Pembroke Welsh corgis and boxers .
23264618	0	SOD1	79,83	superoxide_dismutase	57,77	SOD1	superoxide dismutase	6647	6647	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Disulfide scrambling describes the oligomer formation of superoxide_dismutase -LRB- SOD1 -RRB- proteins in the familial form of amyotrophic_lateral_sclerosis .
23394364	0	SOD1	54,58	superoxide_dismutase	30,50	SOD1	superoxide dismutase	397036(Tax:9823)	397036(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Potential role of the porcine superoxide_dismutase 1 -LRB- SOD1 -RRB- gene in pig reproduction .
22608880	0	SOD1	46,50	superoxide_dismutase-1	22,44	SOD1	superoxide dismutase-1	6647	6647	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic variations in superoxide_dismutase-1 -LRB- SOD1 -RRB- gene and renal and cardiovascular_morbidity and mortality in type 2 diabetic subjects .
10944535	0	SOD1	45,49	superoxide_dismutase_1	21,43	SOD1	superoxide dismutase 1	853568(Tax:4932)	853568(Tax:4932)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Copper activation of superoxide_dismutase_1 -LRB- SOD1 -RRB- in vivo .
25908445	0	SOD1	66,70	superoxide_dismutase_1	4,26	SOD1	superoxide dismutase 1	6647	6647	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|amod|END_ENTITY	The superoxide_dismutase_1 3 ` UTR maintains high expression of the SOD1 gene in cancer cells : The involvement of the RNA-binding_protein AUF-1 .
25578561	0	SOD2	0,4	C-myc	10,15	SOD2	C-myc	6648	4609	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	SOD2 is a C-myc target gene that promotes the migration and invasion of tongue_squamous_cell_carcinoma involving cancer stem-like cells .
23935993	0	SOD2	19,23	MiR-146a	0,8	SOD2	MiR-146a	24787(Tax:10116)	100314241(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-146a regulates SOD2 expression in H2O2 stimulated PC12 cells .
24068327	0	SOD2	23,27	NFkB1	0,5	SOD2	NFkB1	20656(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	NFkB1 -LRB- p50 -RRB- suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis .
25400754	0	SOD2	66,70	PARP1	72,77	SOD2	PARP1	6648	142	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Clinical significance of NQO1 polymorphism and expression of p53 , SOD2 , PARP1 in limited-stage_small_cell_lung_cancer .
12586694	0	SOD2	0,4	Sch9	29,33	SOD2	Sch9	856399(Tax:4932)	856612(Tax:4932)	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	SOD2 functions downstream of Sch9 to extend longevity in yeast .
24939178	0	SOD2	14,18	interleukin-6	38,51	SOD2	interleukin-6	6648	3569	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of SOD2 and b-arrestin1 by interleukin-6 contributes to the increase of IGF-1R expression in docetaxel resistant prostate cancer cells .
9199894	0	SOD2	62,66	manganese_superoxide_dismutase	30,60	SOD2	manganese superoxide dismutase	6648	6648	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Transcriptional inhibition of manganese_superoxide_dismutase -LRB- SOD2 -RRB- gene expression by DNA methylation of the 5 ' CpG island .
25634994	0	SOD3	8,12	EcSOD	14,19	SOD3	EcSOD	6649	6649	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Loss of SOD3 -LRB- EcSOD -RRB- Expression Promotes an Aggressive Phenotype in Human Pancreatic_Ductal_Adenocarcinoma .
7608718	0	SOD_1	40,45	superoxide_dismutase_1	16,38	SOD 1	superoxide dismutase 1	6647	6647	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence of the superoxide_dismutase_1 -LRB- SOD_1 -RRB- gene in familial Parkinson 's _ disease .
11532984	0	SORBS1	68,74	sorbin_and_SH3-domain-containing-1	32,66	SORBS1	sorbin and SH3-domain-containing-1	10580	10580	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular scanning of the human sorbin_and_SH3-domain-containing-1 -LRB- SORBS1 -RRB- gene : positive association of the T228A polymorphism with obesity and type 2 diabetes .
18394047	0	SORBS1	56,62	sorbin_and_SH3-domain-containing-1	20,54	SORBS1	sorbin and SH3-domain-containing-1	10580	10580	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the sorbin_and_SH3-domain-containing-1 -LRB- SORBS1 -RRB- gene and the risk of brain_infarction in the Japanese population : the Fukuoka Stroke Registry and the Hisayama study .
11374898	0	SORBS1	88,94	sorbin_and_SH3_domain_containing_1	52,86	SORBS1	sorbin and SH3 domain containing 1	10580	10580	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning , mapping , and characterization of the human sorbin_and_SH3_domain_containing_1 -LRB- SORBS1 -RRB- gene : a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B .
7782086	0	SORD	66,70	sorbitol_dehydrogenase	37,59	SORD	sorbitol dehydrogenase	6652	6652	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structural organization of the human sorbitol_dehydrogenase gene -LRB- SORD -RRB- .
18938222	0	SORL1	39,44	sortilin-1	27,37	SORL1	sortilin-1	6272	6272	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Allelic mRNA expression of sortilin-1 -LRB- SORL1 -RRB- mRNA in Alzheimer 's autopsy brain tissues .
7737275	0	SOS	39,42	GRB-2	33,38	SOS	GRB-2	34790(Tax:7227)	2885	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	T cell antigen CD28 binds to the GRB-2 / SOS complex , regulators of p21ras .
25071181	0	SOS1	18,22	EGF_receptor	0,12	SOS1	EGF receptor	6654	1956	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	EGF_receptor uses SOS1 to drive constitutive activation of NFkB in cancer cells .
25394671	0	SOS1	0,4	EMP1	86,90	SOS1	EMP1	6654	2012	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1 .
20389169	0	SOS1	31,35	FGFR1	24,29	SOS1	FGFR1	6654	2260	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of FGFR1 , SOS1 , RAF1 genes in cryptorchidism .
12034882	0	SOS1	14,18	SOS2	83,87	SOS1	SOS2	814729(Tax:3702)	833502(Tax:3702)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of SOS1 , a plasma membrane Na + / H + exchanger in Arabidopsis_thaliana , by SOS2 and SOS3 .
12034882	0	SOS2	83,87	SOS1	14,18	SOS2	SOS1	833502(Tax:3702)	814729(Tax:3702)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of SOS1 , a plasma membrane Na + / H + exchanger in Arabidopsis_thaliana , by SOS2 and SOS3 .
15946907	0	SOST	0,4	PTH	26,29	SOST	PTH	80722(Tax:10116)	24694(Tax:10116)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	SOST is a target gene for PTH in bone .
26071314	0	SOST	38,42	sclerostin	26,36	SOST	sclerostin	50964	50964	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	DNA methylation regulates sclerostin -LRB- SOST -RRB- expression in osteoarthritic chondrocytes by bone_morphogenetic_protein_2 -LRB- BMP-2 -RRB- induced changes in Smads binding affinity to the CpG region of SOST promoter .
21221677	0	SOSTDC1	60,67	sclerostin_domain-containing_protein_1	20,58	SOSTDC1	sclerostin domain-containing protein 1	25928	25928	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Contribution of the sclerostin_domain-containing_protein_1 -LRB- SOSTDC1 -RRB- gene to normal variation of peak bone mineral density in Chinese women and men .
26711206	0	SOX10	12,17	CK20	6,10	SOX10	CK20	6663	54474	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CK7 , CK20 , SOX10 and CDX2 : expressions and diagnostic values in primary adenocarcinoma of the sinonasal tract -RSB- .
26711206	0	SOX10	12,17	CK7	1,4	SOX10	CK7	6663	3855	Gene	Gene	-LSB-|nummod|START_ENTITY -LSB-|nummod|END_ENTITY	-LSB- CK7 , CK20 , SOX10 and CDX2 : expressions and diagnostic values in primary adenocarcinoma of the sinonasal tract -RSB- .
11734543	0	SOX10	153,158	Connexin_32	6,17	SOX10	Connexin 32	6663	2705	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Human Connexin_32 , a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth_disease , is directly regulated by the transcription factor SOX10 .
10982026	0	SOX10	89,94	MITF	70,74	SOX10	MITF	6663	4286	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcription factor hierarchy in Waardenburg_syndrome : regulation of MITF expression by SOX10 and PAX3 .
16623715	0	SOX10	0,5	Sp1	27,30	SOX10	Sp1	6663	6667	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	SOX10 , in combination with Sp1 , regulates the endothelin_receptor_type_B gene in human melanocyte lineage cells .
16623715	0	SOX10	0,5	endothelin_receptor_type_B	46,72	SOX10	endothelin receptor type B	6663	1910	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	SOX10 , in combination with Sp1 , regulates the endothelin_receptor_type_B gene in human melanocyte lineage cells .
23321250	0	SOX11	0,5	PAX5	16,20	SOX11	PAX5	20666(Tax:10090)	18507(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SOX11 regulates PAX5 expression and blocks terminal B-cell differentiation in aggressive_mantle_cell_lymphoma .
20074681	0	SOX14	52,57	FOXA2	33,38	SOX14	FOXA2	8403	3170	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression .
18523156	0	SOX17	0,5	Zfp202	25,31	SOX17	Zfp202	64321	7753	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation .
25291942	0	SOX17	61,66	sex-determining_region_Y-box_17	28,59	SOX17	sex-determining region Y-box 17	64321	64321	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Abnormal methylation of the sex-determining_region_Y-box_17 -LRB- SOX17 -RRB- promoter predicts poor prognosis in myelodysplastic_syndrome .
11554755	0	SOX18	0,5	MEF2C	30,35	SOX18	MEF2C	20672(Tax:10090)	17260(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SOX18 directly interacts with MEF2C in endothelial cells .
25986942	0	SOX2	85,89	Akt	70,73	SOX2	Akt	499593(Tax:10116)	24185(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	In oesophageal squamous cells , nitric_oxide causes S-nitrosylation of Akt and blocks SOX2 -LRB- sex_determining_region_Y-box_2 -RRB- expression .
25010701	0	SOX2	0,4	BRAF	32,36	SOX2	BRAF	6657	673	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal_cancer .
25497456	0	SOX2	34,38	C-MYC	0,5	SOX2	C-MYC	6657	4609	Gene	Gene	Target|compound|START_ENTITY Target|compound|END_ENTITY	C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells .
26846300	0	SOX2	0,4	CDKN1A	16,22	SOX2	CDKN1A	6657	1026	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	SOX2 suppresses CDKN1A to sustain growth of lung_squamous_cell_carcinoma .
20410807	0	SOX2	66,70	NANOG	59,64	SOX2	NANOG	6657	79923	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	SOX2	66,70	OCT4	53,57	SOX2	OCT4	6657	5460	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
26762895	0	SOX2	65,69	OCT4	9,13	SOX2	OCT4	6657	5460	Gene	Gene	transcriptional|nmod|START_ENTITY transcriptional|nsubj|END_ENTITY	Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming .
24527393	0	SOX2	19,23	PRDM1	48,53	SOX2	PRDM1	6657	639	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Suppression of the SOX2 neural effector gene by PRDM1 promotes human germ cell fate in embryonic stem cells .
19442651	0	SOX2	20,24	PROP1	0,5	SOX2	PROP1	6657	5626	Gene	Gene	coexists|nmod|START_ENTITY coexists|nsubj|END_ENTITY	PROP1 coexists with SOX2 and induces PIT1-commitment cells .
23932716	0	SOX2	43,47	RMST	23,27	SOX2	RMST	6657	196475	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis .
20410807	0	SOX2	66,70	SALL4	46,51	SOX2	SALL4	6657	57167	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
25132403	0	SOX2	25,29	SIRT1	0,5	SOX2	SIRT1	6657	23411	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SIRT1 directly regulates SOX2 to maintain self-renewal and multipotency in bone marrow-derived mesenchymal stem cells .
26370982	0	SOX2	0,4	Slug	98,102	SOX2	Slug	6657	6591	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|nmod|Transition Transition|nmod|Cells Cells|nmod|Expression Expression|compound|END_ENTITY	SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-a Signaling .
22265740	0	SOX2	38,42	TRKC	30,34	SOX2	TRKC	6657	4916	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells .
20410807	0	SOX2	66,70	UTF1	72,76	SOX2	UTF1	6657	8433	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
23791527	0	SOX2	0,4	YAP1	15,19	SOX2	YAP1	6657	10413	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage .
22542624	0	SOX2	93,97	additional_sex_comb-like_1	23,49	SOX2	additional sex comb-like 1	20674(Tax:10090)	228790(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Positive regulation of additional_sex_comb-like_1 gene expression by the pluripotency factor SOX2 .
23895273	0	SOX2	0,4	fibronectin_1	13,26	SOX2	fibronectin 1	6657	2335	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	SOX2 targets fibronectin_1 to promote cell migration and invasion in ovarian_cancer : new molecular leads for therapeutic intervention .
25986942	0	SOX2	85,89	sex_determining_region_Y-box_2	91,121	SOX2	sex determining region Y-box 2	499593(Tax:10116)	499593(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	In oesophageal squamous cells , nitric_oxide causes S-nitrosylation of Akt and blocks SOX2 -LRB- sex_determining_region_Y-box_2 -RRB- expression .
26862518	0	SOX2OT	58,64	miR-211	27,34	SOX2OT	miR-211	347689	406993	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Down-Regulatory Effects of miR-211 on Long Non-Coding RNA SOX2OT and SOX2 Genes in Esophageal_Squamous_Cell_Carcinoma .
24751947	0	SOX3	27,31	Dbx1	0,4	SOX3	Dbx1	6658	120237	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Dbx1 is a direct target of SOX3 in the spinal cord .
22293114	0	SOX3	43,47	TG-interacting_factor	0,21	SOX3	TG-interacting factor	6658	7050	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	TG-interacting_factor -LRB- TGIF -RRB- downregulates SOX3 gene expression in the NT2/D1 cell line .
25435374	0	SOX30	0,5	p53	113,116	SOX30	p53	11063	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	SOX30 , a novel epigenetic silenced tumor suppressor , promotes tumor cell apoptosis by transcriptional activating p53 in lung_cancer .
26583330	0	SOX4	0,4	ABCG2	111,116	SOX4	ABCG2	6659	9429	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	SOX4 contributes to the progression of cervical_cancer and the resistance to the chemotherapeutic drug through ABCG2 .
25644061	0	SOX4	0,4	EZH2	20,24	SOX4	EZH2	6659	2146	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal_cancer cells .
25644061	0	SOX4	0,4	EZH2	20,24	SOX4	EZH2	6659	2146	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal_cancer cells .
23482931	0	SOX4	0,4	FRA-2	32,37	SOX4	FRA-2	6659	2355	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult_T-cell_leukemia / lymphoma .
26823713	0	SOX4	86,90	MiR-211	0,7	SOX4	MiR-211	6659	406993	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MiR-211 inhibits cell proliferation and invasion of gastric_cancer by down-regulating SOX4 .
16631117	0	SOX4	20,24	Ubc9	0,4	SOX4	Ubc9	6659	7329	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ubc9 interacts with SOX4 and represses its transcriptional activity .
26323722	0	SOX4	135,139	microRNA-204	16,28	SOX4	microRNA-204	6659	406987	Gene	Gene	downregulating|dobj|START_ENTITY cell|advcl|downregulating cell|nsubj|Upregulation Upregulation|nmod|inhibits inhibits|amod|END_ENTITY	Upregulation of microRNA-204 inhibits cell proliferation , migration and invasion in human renal_cell_carcinoma cells by downregulating SOX4 .
26464665	0	SOX4	99,103	microRNA-204	0,12	SOX4	microRNA-204	6659	406987	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	microRNA-204 inhibits cell proliferation in T-cell_acute_lymphoblastic_leukemia by down-regulating SOX4 .
25652387	0	SOX4	0,4	neurogenin_3	21,33	SOX4	neurogenin 3	20677(Tax:10090)	11925(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	SOX4 cooperates with neurogenin_3 to regulate endocrine pancreas formation in mouse models .
21262861	0	SOX5	59,63	SHOX	0,4	SOX5	SHOX	6660	6473	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer .
11504872	0	SOX6	0,4	CtBP2	11,16	SOX6	CtBP2	20679(Tax:10090)	13017(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter .
17412698	0	SOX6	0,4	cyclin_D1	16,25	SOX6	cyclin D1	20679(Tax:10090)	12443(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activity activity|amod|END_ENTITY	SOX6 suppresses cyclin_D1 promoter activity by interacting with beta-catenin and histone_deacetylase_1 , and its down-regulation induces pancreatic beta-cell proliferation .
22492353	0	SOX7	0,4	VE-cadherin	33,44	SOX7	VE-cadherin	20680(Tax:10090)	12562(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development .
15680368	0	SOX7	0,4	VegT	37,41	SOX7	VegT	378665(Tax:8355)	397990(Tax:8355)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	SOX7 is an immediate-early target of VegT and regulates Nodal-related gene expression in Xenopus .
27044823	0	SOX7	64,68	miR-935	0,7	SOX7	miR-935	83595	100126325	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-935 promotes gastric_cancer cell proliferation by targeting SOX7 .
12732652	0	SOX8	0,4	SF1	76,79	SOX8	SF1	20681(Tax:10090)	22668(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro .
20530484	0	SOX9	0,4	BEST1	105,110	SOX9	BEST1	20682(Tax:10090)	24115(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	SOX9 , through interaction with microphthalmia-associated_transcription_factor -LRB- MITF -RRB- and OTX2 , regulates BEST1 expression in the retinal_pigment_epithelium .
18794798	0	SOX9	11,15	CEACAM1	0,7	SOX9	CEACAM1	6662	634	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	CEACAM1 , a SOX9 direct transcriptional target identified in the colon epithelium .
26885752	0	SOX9	0,4	CEACAM1	26,33	SOX9	CEACAM1	6662	634	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SOX9 indirectly regulates CEACAM1 expression and immune resistance in melanoma cells .
19113914	0	SOX9	0,4	CREB	20,24	SOX9	CREB	6662	1385	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	SOX9 directly binds CREB as a novel synergism with the PKA pathway in BMP-2-induced osteochondrogenic differentiation .
25336113	0	SOX9	0,4	ERBB	15,19	SOX9	ERBB	6662	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SOX9 regulates ERBB signalling in pancreatic_cancer development .
23660500	0	SOX9	0,4	IGFBP-4	24,31	SOX9	IGFBP-4	20682(Tax:10090)	16010(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SOX9 directly regulates IGFBP-4 in the intestinal epithelium .
22488688	0	SOX9	44,48	Osteopontin	0,11	SOX9	Osteopontin	6662	6696	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver_fibrosis in humans .
15889150	0	SOX9	70,74	Prostaglandin_D2	0,16	SOX9	Prostaglandin D2	6662	5730	Gene	Gene	import|nmod|START_ENTITY induces|dobj|import induces|nsubj|END_ENTITY	Prostaglandin_D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation .
19254740	0	SOX9	29,33	RelA	61,65	SOX9	RelA	6662	5970	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells .
21592645	0	SOX9	20,24	SRY	0,3	SOX9	SRY	6662	6736	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|compound|END_ENTITY	SRY upregulation of SOX9 is inefficient and delayed , allowing ovarian differentiation , in the B6.Y -LRB- TIR -RRB- gonad .
15623506	0	SOX9	55,59	Smad3	0,5	SOX9	Smad3	6662	4088	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding_protein / p300 recruitment .
17289023	0	SOX9	24,28	Sp1	41,44	SOX9	Sp1	6662	6667	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the human SOX9 promoter by Sp1 and CREB .
24144697	0	SOX9	15,19	TAK1	0,4	SOX9	TAK1	20682(Tax:10090)	26409(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages .
23306204	0	SOX9	0,4	low_density_lipoprotein_receptor-related_protein_6	15,65	SOX9	low density lipoprotein receptor-related protein 6	6662	4040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SOX9 regulates low_density_lipoprotein_receptor-related_protein_6 -LRB- LRP6 -RRB- and T-cell_factor_4 -LRB- TCF4 -RRB- expression and Wnt/b-catenin activation in breast_cancer .
25145279	0	SOX9	29,33	miR-145	37,44	SOX9	miR-145	6662	406937	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma .
17277314	0	SOX9	0,4	prostaglandin_D_synthase	15,39	SOX9	prostaglandin D synthase	20682(Tax:10090)	19215(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	SOX9 regulates prostaglandin_D_synthase gene transcription in vivo to ensure testis development .
17532558	0	SOX9	63,67	prostaglandin_D_synthase	38,62	SOX9	prostaglandin D synthase	6662	5730	Gene	Gene	pathway|nummod|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	Expression and biological role of the prostaglandin_D_synthase / SOX9 pathway in human ovarian_cancer cells .
18588874	0	SP-1	84,88	HDAC1	89,94	SP-1	HDAC1	6667	3065	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|END_ENTITY	Induction of truncated form of tenascin-X -LRB- XB-S -RRB- through dissociation of HDAC1 from SP-1 / HDAC1 complex in response to hypoxic conditions .
22519702	0	SP-1	0,4	MMP-9	19,24	SP-1	MMP-9	6667	4318	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	SP-1 regulation of MMP-9 expression requires Ser586 in the PEST domain .
20054143	0	SP-A	18,22	P63	0,3	SP-A	P63	20387(Tax:10090)	216197(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	P63 -LRB- CKAP4 -RRB- as an SP-A receptor : implications for surfactant turnover .
16500946	0	SP-A	41,45	SP-A	8,12	SP-A	SP-A	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis .
16500946	0	SP-A	8,12	SP-A	41,45	SP-A	SP-A	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis .
15244040	0	SP-A	28,32	Surfactant_protein_A_and_D	0,26	SP-A	Surfactant protein A and D	653509	653509;6441	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Surfactant_protein_A_and_D -LRB- SP-A , AP-D -RRB- levels in patients with septic ARDS .
12114204	0	SP-A	19,23	TNF-alpha	0,9	SP-A	TNF-alpha	653509	7124	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK .
11713256	0	SP-A	96,100	pulmonary_surfactant_protein-A	64,94	SP-A	pulmonary surfactant protein-A	653509	653509	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary_surfactant_protein-A -LRB- SP-A -RRB- gene by thyroid_transcription_factor-1 -LRB- TTF-1 -RRB- .
9475280	0	SP-A	47,51	pulmonary_surfactant_protein_A	15,45	SP-A	pulmonary surfactant protein A	653509	653509	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of pulmonary_surfactant_protein_A -LRB- SP-A -RRB- gene and respiratory_distress_syndrome : interaction with SP-B .
1289235	0	SP-A	56,60	surfactant-associated_protein	25,54	SP-A	surfactant-associated protein	729238	729238	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of pulmonary surfactant-associated_protein -LRB- SP-A -RRB- with surfactant lipids .
2167698	0	SP-A	33,37	surfactant_protein	13,31	SP-A	surfactant protein	24773(Tax:10116)	24773(Tax:10116)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of surfactant_protein -LRB- SP-A -RRB- biosynthesis and SP-A mRNA in activated type II cells during acute silicosis in rats .
15047952	0	SP-A	75,79	surfactant_protein-A	53,73	SP-A	surfactant protein-A	653509	653509	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Linkage of neutrophil serine proteases and decreased surfactant_protein-A -LRB- SP-A -RRB- levels in inflammatory_lung_disease .
16621351	4	SP-A	416,420	surfactant_protein-A	394,414	SP-C	surfactant protein-C	6440	6440	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	There are four non-serum proteins surfactant_protein-A -LRB- SP-A -RRB- , surfactant_protein-B -LRB- SP-B -RRB- , surfactant_protein-C -LRB- SP-C -RRB- and surfactant_protein-D -LRB- SP-D -RRB- named in chronologic order of discovery .
17307210	0	SP-A	30,34	surfactant_protein-A	8,28	SP-A	surfactant protein-A	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of surfactant_protein-A -LRB- SP-A -RRB- in lung_injury in response to acute ozone exposure of SP-A deficient mice .
18079322	0	SP-A	75,79	surfactant_protein-A	53,73	SP-A	surfactant protein-A	653509	653509	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Glucocorticoid/glucocorticoid _ receptor inhibition of surfactant_protein-A -LRB- SP-A -RRB- gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter .
10762543	0	SP-A	46,50	surfactant_protein_A	24,44	SP-A	surfactant protein A	653509	653509	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the surfactant_protein_A -LRB- SP-A -RRB- gene locus and respiratory-distress_syndrome in the Finnish population .
11028547	0	SP-A	32,36	surfactant_protein_A	10,30	SP-A	surfactant protein A	653509	653509	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of surfactant_protein_A -LRB- SP-A -RRB- on the production of cytokines by human pulmonary macrophages .
11751208	0	SP-A	70,74	surfactant_protein_A	48,68	SP-A	surfactant protein A	653509	653509	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Intracellular and intraalveolar localization of surfactant_protein_A -LRB- SP-A -RRB- in the parenchymal region of the human lung .
12020822	0	SP-A	113,117	surfactant_protein_A	91,111	SP-A	surfactant protein A	24773(Tax:10116)	24773(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant_protein_A -LRB- SP-A -RRB- genes .
15932345	0	SP-A	15,19	surfactant_protein_A	21,41	SP-A	surfactant protein A	653509	653509	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of SP-A -LRB- surfactant_protein_A -RRB- with bacterial rough lipopolysaccharide -LRB- Re-LPS -RRB- , and effects of SP-A on the binding of Re-LPS to CD14 and LPS-binding_protein .
1846339	0	SP-A	51,55	surfactant_protein_A	29,49	SP-A	surfactant protein A	24773(Tax:10116)	653509	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of lung surfactant_protein_A -LRB- SP-A -RRB- with rat alveolar macrophages .
18581277	0	SP-A	68,72	surfactant_protein_A	46,66	SP-A	surfactant protein A	653509	653509	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Histological findings and immunohistochemical surfactant_protein_A -LRB- SP-A -RRB- expression in asphyxia : its application in the diagnosis of drowning .
21402781	0	SP-A	52,56	surfactant_protein_A	25,45	SP-A	surfactant protein A	653509	653509	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Epigenetic regulation of surfactant_protein_A gene -LRB- SP-A -RRB- expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia .
23328842	0	SP-A	121,125	surfactant_protein_A	99,119	SP-A	surfactant protein A	653509	653509	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Allelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant_protein_A -LRB- SP-A -RRB- gene .
24007361	0	SP-A	59,63	surfactant_protein_A	37,57	SP-A	surfactant protein A	653509	653509	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pilot study exploring lung allograft surfactant_protein_A -LRB- SP-A -RRB- expression in association with lung transplant outcome .
7532637	0	SP-A	38,42	surfactant_protein_A	16,36	SP-A	surfactant protein A	24773(Tax:10116)	24773(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of surfactant_protein_A -LRB- SP-A -RRB- in alveolar_macrophage subpopulations of normal and fibrotic rat lung .
7896788	0	SP-A	66,70	surfactant_protein_A	44,64	SP-A	surfactant protein A	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lung cell-specific expression of the murine surfactant_protein_A -LRB- SP-A -RRB- gene is mediated by interactions between the SP-A promoter and thyroid_transcription_factor-1 .
20036966	0	SP-A	36,40	surfactant_protein_A_and_D	8,34	SP-A	surfactant protein A and D	653509	653509;6441	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of surfactant_protein_A_and_D -LRB- SP-A and SP-D -RRB- in human antiviral host defense .
2188684	0	SP-B	64,68	surfactant-associated_protein_B	31,62	SP-B	surfactant-associated protein B	507398(Tax:9913)	6439	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of mature pulmonary surfactant-associated_protein_B -LRB- SP-B -RRB- in Escherichia_coli using truncated human SP-B cDNAs .
8216208	0	SP-B	48,52	surfactant-associated_protein_B	15,46	SP-B	surfactant-associated protein B	6439	6439	Gene	Gene	Degradation|appos|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of surfactant-associated_protein_B -LRB- SP-B -RRB- during in vitro conversion of large to small surfactant aggregates .
1850607	0	SP-B	46,50	surfactant_protein_B	24,44	SP-B	surfactant protein B	192155(Tax:10116)	192155(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Hormonal effects on the surfactant_protein_B -LRB- SP-B -RRB- mRNA in cultured fetal rat lung .
23272120	0	SP-B	90,94	surfactant_protein_B	68,88	SP-B	surfactant protein B	6439	6439	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Synergistic effect of caffeine and glucocorticoids on expression of surfactant_protein_B -LRB- SP-B -RRB- mRNA .
9006959	0	SP-B	45,49	surfactant_protein_B	23,43	SP-B	surfactant protein B	6439	6439	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Functional analysis of surfactant_protein_B -LRB- SP-B -RRB- promoter .
15531758	0	SP-C	15,19	FGF-10	0,6	SP-C	FGF-10	6440	2255	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal_epithelium .
1540386	0	SP-C	49,53	surfactant-associated_protein_C	16,47	SP-C	surfactant-associated protein C	100009162(Tax:9986)	100009162(Tax:9986)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of surfactant-associated_protein_C -LRB- SP-C -RRB- mRNA in fetal rabbit lung tissue by in situ hybridization .
24660467	0	SP-C1	55,60	IL-8	36,40	SP-C1	IL-8	28972	3576	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	8-hydroxycudraxanthone_G suppresses IL-8 production in SP-C1 tongue_cancer cells .
17511270	0	SP-D	48,52	KL-6	54,58	SP-D	KL-6	6441	4582	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- Immunity tests for respiratory_diseases -- SP-A , SP-D , KL-6 -RSB- .
21637370	0	SP-D	52,56	MUC1	23,27	SP-D	MUC1	6441	4582	Gene	Gene	Independent|nmod|START_ENTITY Independent|compound|END_ENTITY	A Normal Range of KL-6 / MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography .
11967276	0	SP-D	44,48	surfactant_protein-D	22,42	SP-D	surfactant protein-D	6441	6441	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of surfactant_protein-D -LRB- SP-D -RRB- in human fetal , newborn , and adult tissues .
9844346	0	SP-D	45,49	surfactant_protein-D	23,43	SP-D	surfactant protein-D	6441	6441	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	-LSB- Significance of serum surfactant_protein-D -LRB- SP-D -RRB- level in patients with pulmonary_tuberculosis -RSB- .
14742512	0	SP-D	85,89	surfactant_protein_D	63,83	SP-D	surfactant protein D	6441	6441	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding and agglutination of Streptococcus_pneumoniae by human surfactant_protein_D -LRB- SP-D -RRB- vary between strains , but SP-D fails to enhance killing by neutrophils .
1527377	0	SP-D	57,61	surfactant_protein_D	35,55	SP-D	surfactant protein D	25350(Tax:10116)	25350(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of surfactant_protein_D -LRB- SP-D -RRB- in type II cells , Clara cells , and alveolar macrophages of rat lung .
25134376	0	SP-D	46,50	surfactant_protein_D	24,44	SP-D	surfactant protein D	6441	6441	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	The evaluation of serum surfactant_protein_D -LRB- SP-D -RRB- levels as a biomarker of lung_injury in tuberculosis and different lung_diseases .
26299656	0	SP1	0,3	ADAMTS1	36,43	SP1	ADAMTS1	6667	9510	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nummod|END_ENTITY	SP1 and USF differentially regulate ADAMTS1 gene expression under normoxic and hypoxic_conditions in hepatoma cells .
19124744	0	SP1	88,91	CCL5	57,61	SP1	CCL5	6667	6352	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|transcription transcription|nmod|END_ENTITY	JNK MAPK pathway regulates constitutive transcription of CCL5 by human NK cells through SP1 .
23137637	0	SP1	40,43	CEP131	14,20	SP1	CEP131	6667	22994	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of CEP131 gene expression by SP1 .
26727275	0	SP1	11,14	COL1A1	4,10	SP1	COL1A1	6667	1277	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic_acid .
10556800	0	SP1	41,44	FasL	0,4	SP1	FasL	6667	356	Gene	Gene	activation|nmod|START_ENTITY promoter|acl|activation promoter|amod|END_ENTITY	FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3 .
16226779	0	SP1	29,32	Gag	43,46	SP1	Gag	6667	155030(Tax:11676)	Gene	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	The T12I mutation within the SP1 region of Gag restricts packaging of spliced viral RNA into human_immunodeficiency_virus_type_1 with mutated RNA packaging signals and mutated nucleocapsid sequence .
23131565	0	SP1	50,53	HIF-1a	92,98	SP1	HIF-1a	6667	3091	Gene	Gene	specific_protein_1|appos|START_ENTITY specific_protein_1|nmod|hypoxia-inducible_factor_1_alpha hypoxia-inducible_factor_1_alpha|appos|END_ENTITY	Transcriptional regulation of specific_protein_1 -LRB- SP1 -RRB- by hypoxia-inducible_factor_1_alpha -LRB- HIF-1a -RRB- leads to PRNP expression and neuroprotection from toxic prion peptide .
15480988	0	SP1	79,82	ICAM-1	120,126	SP1	ICAM-1	6667	3383	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1 - and NF-kappaB-mediated induction of ICAM-1 .
10556800	0	SP1	41,44	IL-2	28,32	SP1	IL-2	6667	3558	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3 .
12016466	0	SP1	17,20	Ia1	13,16	SP1	Ia1	6667	3642	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The collagen Ia1 SP1 polymorphism is associated with differences in ultrasound transmission velocity in the calcaneus in postmenopausal women .
8103518	0	SP1	0,3	MDR1	18,22	SP1	MDR1	6667	5243	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity .
1736522	0	SP1	75,78	P38	15,18	SP1	P38	6667	1432	Gene	Gene	site|compound|START_ENTITY region|appos|site requires|dobj|region requires|nsubj|promoter promoter|compound|END_ENTITY	Parvovirus_H-1 P38 promoter requires the trans-activation region -LRB- tar -RRB- , an SP1 site , and a TATA box for full activity .
6160287	0	SP1	61,64	PP5	106,109	SP1	PP5	6667	7980	Gene	Gene	1-glycoprotein|appos|START_ENTITY 1-glycoprotein|appos|END_ENTITY	Ectopic synthesis of pregnancy specific beta 1-glycoprotein -LRB- SP1 -RRB- and placental specific tissue proteins -LRB- PP5 , PP10 , PP11 , PP12 -RRB- in nontrophoblastic malignant_tumours .
6755403	0	SP1	61,64	PP5	105,108	SP1	PP5	6667	7980	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Immunohistochemical detection of pregnancy-specific protein -LRB- SP1 -RRB- and placenta-specific tissue proteins -LRB- PP5 , PP10 , PP11 and PP12 -RRB- in ovarian_adenocarcinomas .
6972740	0	SP1	92,95	PP5	128,131	SP1	PP5	6667	7980	Gene	Gene	1-glycoprotein|appos|START_ENTITY 1-glycoprotein|appos|PP8 PP8|compound|END_ENTITY	Immunohistochemical location of proteins related to pregnancy-specific beta 1-glycoprotein -LRB- SP1 -RRB- and placental tissue proteins -LRB- PP5 , PP8 , PP9 , PP10 , PP11 , PP12 -RRB- in the afterbirth of Cynomolgus_monkeys -LRB- Macaca_fascicularis -RRB- .
6975467	0	SP1	79,82	PP5	37,40	SP1	PP5	6667	7980	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Detection of placental protein five -LRB- PP5 -RRB- and pregnancy-specific glycoprotein -LRB- SP1 -RRB- in benign and malignant breast_disease .
6611014	0	SP1	40,43	Pregnancy-specific_beta_1-glycoprotein	0,38	SP1	Pregnancy-specific beta 1-glycoprotein	6667	6667	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Pregnancy-specific_beta_1-glycoprotein -LRB- SP1 -RRB- levels measured by nephelometry in serum from women with vaginal_bleeding in the first half of pregnancy .
9591776	0	SP1	39,42	Retinoblastoma	0,14	SP1	Retinoblastoma	6667	5925	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate_reductase promoter .
18194215	0	SP1	0,3	SNAP-25	22,29	SP1	SNAP-25	6667	6616	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SP1 regulates a human SNAP-25 gene expression .
1662663	0	SP1	35,38	Sp1	4,7	SP1	Sp1	6667	24790(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Sp1 transcription factor gene -LRB- SP1 -RRB- and the 1,25-dihydroxyvitamin _ D3 receptor gene -LRB- VDR -RRB- are colocalized on human chromosome arm 12q and rat chromosome 7 .
16256024	0	SP1	56,59	TGFbeta1	12,20	SP1	TGFbeta1	24790(Tax:10116)	59086(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	-LSB- Effects of TGFbeta1 on the transcriptional activity of SP1 , AP1 and Smad3-Smad4 in lung fibroblasts -RSB- .
19723341	0	SP1	0,3	Zbtb7A	13,19	SP1	Zbtb7A	6667	51341	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	SP1 enhances Zbtb7A gene expression via direct binding to GC box in HePG2 cells .
22820659	0	SP1	60,63	estrogen_receptor	25,42	SP1	estrogen receptor	6667	2099	Gene	Gene	antibody|compound|START_ENTITY sensitive|nsubj|antibody shows|ccomp|sensitive shows|nsubj|analysis analysis|nmod|expression expression|compound|END_ENTITY	Quantitative analysis of estrogen_receptor expression shows SP1 antibody is more sensitive than 1D5 .
1723674	0	SP1	6,9	hPL	11,14	SP1	hPL	6667	3956	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Serum SP1 , hPL and beta-hCG levels in trophoblastic_diseases .
6416936	0	SP1	56,59	pregnancy-specific_beta_1-glycoprotein	16,54	SP1	pregnancy-specific beta 1-glycoprotein	653492	653492	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of pregnancy-specific_beta_1-glycoprotein -LRB- SP1 -RRB- in women with pregnancies at risk .
6973005	0	SP1	62,65	specific_beta_1-glycoprotein	32,60	SP1	specific beta 1-glycoprotein	6667	6667	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Circulating levels of pregnancy specific_beta_1-glycoprotein -LRB- SP1 -RRB- in normal pregnancy and in intrauterine_growth_retardation .
21618058	0	SP1	103,106	specificity_protein_1	80,101	SP1	specificity protein 1	24790(Tax:10116)	24790(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Rat pancreatic level of cystathionine y-lyase is regulated by glucose level via specificity_protein_1 -LRB- SP1 -RRB- phosphorylation .
18780375	0	SP1	50,53	storage_protein_1	31,48	SP1	storage protein 1	6667	6667	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of storage_protein_1 -LRB- SP1 -RRB- in differentiated fat body tissues of red hairy caterpillar , Amsacta albistriga Walker .
15247905	0	SP100	0,5	ETS1	27,31	SP100	ETS1	6672	2113	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion .
26347895	0	SP100	47,52	SP140L	0,6	SP100	SP140L	6672	93349	Gene	Gene	Family|compound|START_ENTITY Member|nmod|Family END_ENTITY|appos|Member	SP140L , an Evolutionarily Recent Member of the SP100 Family , Is an Autoantigen in Primary_Biliary_Cirrhosis .
26347895	0	SP100	47,52	SP140L	0,6	SP100	SP140L	6672	93349	Gene	Gene	Family|compound|START_ENTITY Member|nmod|Family END_ENTITY|appos|Member	SP140L , an Evolutionarily Recent Member of the SP100 Family , Is an Autoantigen in Primary_Biliary_Cirrhosis .
26347895	0	SP140L	0,6	SP100	47,52	SP140L	SP100	93349	6672	Gene	Gene	START_ENTITY|appos|Member Member|nmod|Family Family|compound|END_ENTITY	SP140L , an Evolutionarily Recent Member of the SP100 Family , Is an Autoantigen in Primary_Biliary_Cirrhosis .
26347895	0	SP140L	0,6	SP100	47,52	SP140L	SP100	93349	6672	Gene	Gene	START_ENTITY|appos|Member Member|nmod|Family Family|compound|END_ENTITY	SP140L , an Evolutionarily Recent Member of the SP100 Family , Is an Autoantigen in Primary_Biliary_Cirrhosis .
7870588	0	SP2	70,73	U2af1-rs1	59,68	SP2	U2af1-rs1	78912(Tax:10090)	22183(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Allele-specific methylation and expression of an imprinted U2af1-rs1 -LRB- SP2 -RRB- gene .
15704685	0	SP22	46,50	sperm_protein_22	28,44	SP22	sperm protein 22	10935	10935	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Advances in the studies of sperm_protein_22 -LRB- SP22 -RRB- -RSB- .
17609507	0	SP22	32,36	sperm_protein_22	14,30	SP22	sperm protein 22	117287(Tax:10116)	117287(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of sperm_protein_22 -LRB- SP22 -RRB- in the rat ovary during different reproductive states .
11432740	0	SP3	0,3	lamin_A	55,62	SP3	lamin A	31917(Tax:7227)	36615(Tax:7227)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|promoter promoter|amod|END_ENTITY	SP3 and AP-1 mediate transcriptional activation of the lamin_A proximal promoter .
15474293	0	SP7	93,96	Osterix	84,91	SP7	Osterix	121340	121340	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning , structure , expression , and chromosomal localization of the human Osterix -LRB- SP7 -RRB- gene .
23967141	0	SP8	67,70	Sp8_transcription_factor	36,60	SP8	Sp8 transcription factor	221833	221833	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variants on 3q21 and in the Sp8_transcription_factor gene -LRB- SP8 -RRB- as susceptibility loci for psychotic_disorders : a genetic association study .
15456879	0	SPA-1	52,57	Brd4	20,24	SPA-1	Brd4	6494	23476	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Bromodomain protein Brd4 binds to GTPase-activating SPA-1 , modulating its activity and subcellular localization .
11461903	0	SPA1	50,54	COP1	79,83	SPA1	COP1	819242(Tax:3702)	817857(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The phytochrome_A-specific signaling intermediate SPA1 interacts directly with COP1 , a constitutive repressor of light signaling in Arabidopsis .
21511871	0	SPA1	42,46	COP1	59,63	SPA1	COP1	819242(Tax:3702)	817857(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|suppress suppress|dobj|activity activity|nummod|END_ENTITY	Arabidopsis cryptochrome_1 interacts with SPA1 to suppress COP1 activity in response to blue light .
21514160	0	SPA1	46,50	COP1	61,65	SPA1	COP1	819242(Tax:3702)	817857(Tax:3702)	Gene	Gene	CRY2|nmod|START_ENTITY interaction|nmod|CRY2 regulates|nsubj|interaction regulates|dobj|activity activity|compound|END_ENTITY	Blue light-dependent interaction of CRY2 with SPA1 regulates COP1 activity and floral initiation in Arabidopsis .
21511871	0	SPA1	42,46	cryptochrome_1	12,26	SPA1	cryptochrome 1	819242(Tax:3702)	826470(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arabidopsis cryptochrome_1 interacts with SPA1 to suppress COP1 activity in response to blue light .
16643671	0	SPAG11	94,100	sperm_associated_antigen_11	65,92	SPAG11	sperm associated antigen 11	246305(Tax:10116)	246305(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Identification , cloning and functional characterization of novel sperm_associated_antigen_11 -LRB- SPAG11 -RRB- isoforms in the rat .
19548270	0	SPAG8	78,83	sperm_associated_antigen_8	50,76	SPAG8	sperm associated antigen 8	26206	26206	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Regulation of the G2/M phase of the cell cycle by sperm_associated_antigen_8 -LRB- SPAG8 -RRB- protein .
26233565	0	SPAK	85,89	EAAT1	54,59	SPAK	EAAT1	446749(Tax:8355)	398856(Tax:8355)	Gene	Gene	Down-Regulation|nmod|START_ENTITY Down-Regulation|nmod|END_ENTITY	Down-Regulation of Excitatory Amino_Acid Transporters EAAT1 and EAAT2 by the Kinases SPAK and OSR1 .
26160150	0	SPAK	0,4	ENaC	55,59	SPAK	ENaC	53416(Tax:10090)	20276(Tax:10090)	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|END_ENTITY	SPAK Sensitive Regulation of the Epithelial Na Channel ENaC .
18550547	0	SPAK	26,30	NKCC1	52,57	SPAK	NKCC1	27347	6558	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells .
20223824	0	SPAK	234,238	NKCC1	88,93	SPAK	NKCC1	446749(Tax:8355)	100037166(Tax:8355)	Gene	Gene	serves|dep|START_ENTITY phosphatase|parataxis|serves phosphatase|dobj|regulation regulation|nmod|function function|appos|END_ENTITY	Multiple pathways for protein phosphatase 1 -LRB- PP1 -RRB- regulation of Na-K-2Cl_cotransporter -LRB- NKCC1 -RRB- function : the N-terminal tail of the Na-K-2Cl_cotransporter serves as a regulatory scaffold for Ste20-related_proline / alanine-rich_kinase -LRB- SPAK -RRB- AND PP1 .
24133122	0	SPAK	43,47	NKCC2	14,19	SPAK	NKCC2	27347	6557	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Regulation of NKCC2 activity by inhibitory SPAK isoforms : KS-SPAK is a more potent inhibitor than SPAK2 .
17595523	0	SPAK	39,43	Na-K-2Cl_cotransporter	62,84	SPAK	Na-K-2Cl cotransporter	446749(Tax:8355)	100037166(Tax:8355)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	A single binding motif is required for SPAK activation of the Na-K-2Cl_cotransporter .
26506223	0	SPAK	84,88	NaPi-IIb	50,58	SPAK	NaPi-IIb	53416(Tax:10090)	432056(Tax:8355)	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|nmod|END_ENTITY	Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb -LRB- SLC34A2 -RRB- by the Kinases SPAK and OSR1 .
25322850	0	SPAK	0,4	ROMK1	82,87	SPAK	ROMK1	53416(Tax:10090)	447262(Tax:8355)	Gene	Gene	Down-Regulation|compound|START_ENTITY Down-Regulation|nmod|END_ENTITY	SPAK and OSR1 Dependent Down-Regulation of Murine Renal Outer Medullary K Channel ROMK1 .
26506223	0	SPAK	84,88	SLC34A2	60,67	SPAK	SLC34A2	53416(Tax:10090)	20531(Tax:10090)	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|appos|END_ENTITY	Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb -LRB- SLC34A2 -RRB- by the Kinases SPAK and OSR1 .
12932297	0	SPAM1	0,5	PH-20	7,12	SPAM1	PH-20	6677	6677	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	SPAM1 -LRB- PH-20 -RRB- protein and mRNA expression in the epididymides of humans and macaques : utilizing laser microdissection/RT-PCR .
20687958	0	SPARC	70,75	Brg-1	0,5	SPARC	Brg-1	6678	6597	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary_carcinoma cells via its interaction with transcription factor Sp1 .
15890490	0	SPARC	50,55	Cyclosporin_A	23,36	SPARC	Cyclosporin A	6678	1161	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Differential effect of Cyclosporin_A and FK506 on SPARC mRNA expression by human gingival fibroblasts .
16885349	0	SPARC	0,5	E-cadherin	16,26	SPARC	E-cadherin	6678	999	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	SPARC represses E-cadherin and induces mesenchymal transition during melanoma development .
12169206	0	SPARC	13,18	FHIT	7,11	SPARC	FHIT	6678	2272	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	MYCL1 , FHIT , SPARC , p16 -LRB- INK4 -RRB- and TP53 genes associated to lung_cancer in idiopathic_pulmonary_fibrosis .
12169206	0	SPARC	13,18	INK4	24,28	SPARC	INK4	6678	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	MYCL1 , FHIT , SPARC , p16 -LRB- INK4 -RRB- and TP53 genes associated to lung_cancer in idiopathic_pulmonary_fibrosis .
16084059	0	SPARC	110,115	MMP-2	53,58	SPARC	MMP-2	6678	4313	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Effect of resveratrol on matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and Secreted_Protein_Acidic_and_Rich_in_Cysteine -LRB- SPARC -RRB- on human cultured glioblastoma cells .
20975318	0	SPARC	99,104	MMP-9	68,73	SPARC	MMP-9	6678	4318	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Ukrain affects pancreas cancer cell phenotype in vitro by targeting MMP-9 and intra - / extracellular SPARC expression .
17490812	0	SPARC	0,5	MT1-MMP	18,25	SPARC	MT1-MMP	6678	4323	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	SPARC upregulates MT1-MMP expression , MMP-2 activation , and the secretion and cleavage of galectin-3 in U87MG glioma cells .
22539874	0	SPARC	20,25	Pax6	0,4	SPARC	Pax6	20692(Tax:10090)	18508(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pax6 interacts with SPARC and TGF-b in murine eyes .
17343824	0	SPARC	16,21	SATB1	0,5	SPARC	SATB1	6678	6304	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron .
17625595	0	SPARC	56,61	SPARC	98,103	SPARC	SPARC	6678	6678	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	SPARC endogenous level , rather than fibroblast-produced SPARC or stroma reorganization induced by SPARC , is responsible for melanoma cell growth .
17625595	0	SPARC	98,103	SPARC	56,61	SPARC	SPARC	6678	6678	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	SPARC endogenous level , rather than fibroblast-produced SPARC or stroma reorganization induced by SPARC , is responsible for melanoma cell growth .
25355716	0	SPARC	60,65	Secreted_Protein_Acidic_and_Rich_in_Cysteine	14,58	SPARC	Secreted Protein Acidic and Rich in Cysteine	6678	6678	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Secreted_Protein_Acidic_and_Rich_in_Cysteine -LRB- SPARC -RRB- in Breast_Cancer and Response to Neoadjuvant Chemotherapy .
25925867	0	SPARC	15,20	VCAM1	88,93	SPARC	VCAM1	6678	7412	Gene	Gene	drives|nsubj|START_ENTITY drives|nmod|END_ENTITY	Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis .
11554745	0	SPARC	13,18	VEGF	22,26	SPARC	VEGF	6678	7422	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of SPARC by VEGF in human vascular endothelial cells .
17133596	0	SPARC	0,5	connective_tissue_growth_factor	32,63	SPARC	connective tissue growth factor	6678	1490	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	SPARC , an upstream regulator of connective_tissue_growth_factor in response to transforming_growth_factor_beta stimulation .
15150282	0	SPARC	71,76	hevin	42,47	SPARC	hevin	20692(Tax:10090)	13602(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Expression and characterization of murine hevin -LRB- SC1 -RRB- , a member of the SPARC family of matricellular proteins .
16428937	0	SPARC	97,102	matrix_metalloproteinase-2	20,46	SPARC	matrix metalloproteinase-2	6678	4313	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of Ukrain on matrix_metalloproteinase-2 and Secreted_Protein_Acidic_and_Rich_in_Cysteine -LRB- SPARC -RRB- expression in human glioblastoma cells .
10757117	0	SPARC	62,67	secreted_protein_acidic_and_rich_in_cysteine	16,60	SPARC	secreted protein acidic and rich in cysteine	24791(Tax:10116)	24791(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Localization of secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- expression in the rat eye .
16735494	0	SPARC	114,119	secreted_protein_acidic_and_rich_in_cysteine	68,112	SPARC	secreted protein acidic and rich in cysteine	6678	6678	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential zonal expression and adrenocorticotropin regulation of secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- , a matricellular protein , in the midgestation human fetal adrenal gland : implications for adrenal development .
17041094	0	SPARC	103,108	secreted_protein_acidic_and_rich_in_cysteine	57,101	SPARC	secreted protein acidic and rich in cysteine	6678	6678	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Expression of a suicidal gene under control of the human secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- promoter in tumor or stromal cells led to the inhibition of tumor cell growth .
22145659	0	SPARC	59,64	secreted_protein_acidic_and_rich_in_cysteine	13,57	SPARC	secreted protein acidic and rich in cysteine	6678	6678	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Knockdown of secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- expression diminishes radiosensitivity of glioma cells .
12101446	0	SPARC	133,138	thrombospondin_1	99,115	SPARC	thrombospondin 1	6678	7057	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Pathobiology of epiretinal and subretinal membranes : possible roles for the matricellular proteins thrombospondin_1 and osteonectin -LRB- SPARC -RRB- .
12468382	0	SPARC	64,69	transforming_growth_factor-beta_1	11,44	SPARC	transforming growth factor-beta 1	6678	7040	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of transforming_growth_factor-beta_1 and fibronectin on SPARC expression in cultures of human periodontal ligament cells .
9792673	0	SPARC	0,5	vascular_endothelial_growth_factor	60,94	SPARC	vascular endothelial growth factor	6678	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	SPARC -LRB- BM-40 , osteonectin -RRB- inhibits the mitogenic effect of vascular_endothelial_growth_factor on microvascular endothelial cells .
21300779	0	SPATA18	0,7	p53	81,84	SPATA18	p53	73472(Tax:10090)	22060(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	SPATA18 , a spermatogenesis-associated gene , is a novel transcriptional target of p53 and p63 .
15831449	0	SPBP	0,4	estrogen_receptor_alpha	46,69	SPBP	estrogen receptor alpha	6942	2099	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	SPBP is a phosphoserine-specific repressor of estrogen_receptor_alpha .
15182504	0	SPC-A-1	79,86	epidermal_growth_factor_receptor	32,64	SPC-A-1	epidermal growth factor receptor	27032	1956	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	-LSB- Effects of RNA interference on epidermal_growth_factor_receptor expression in SPC-A-1 cells -RSB- .
9148931	0	SPC22/23	10,18	Spc3p	27,32	SPC22/23	Spc3p	7554741(Tax:476213)	850755(Tax:4932)	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity .
9073064	0	SPE3	98,102	spermidine_synthase	109,128	SPE3	spermidine synthase	856182(Tax:4932)	856182(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Spermidine biosynthesis in Saccharomyces cerevisae : polyamine requirement of a null mutant of the SPE3 gene -LRB- spermidine_synthase -RRB- .
9573363	0	SPE4	88,92	spermine_synthase	99,116	SPE4	spermine synthase	850838(Tax:4932)	850838(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Spermine is not essential for growth of Saccharomyces_cerevisiae : identification of the SPE4 gene -LRB- spermine_synthase -RRB- and characterization of a spe4 deletion mutant .
10656459	0	SPEC-2	100,106	p21	41,44	SPEC-2	p21	56990	644914	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Adenovirus-mediated expression of p53 or p21 in a papillary_serous_endometrial_carcinoma cell line -LRB- SPEC-2 -RRB- results in both growth inhibition and apoptotic cell death : potential application of gene therapy to endometrial_cancer .
19889948	0	SPEF2	14,19	IFT20	71,76	SPEF2	IFT20	320277(Tax:10090)	55978(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of SPEF2 during mouse spermatogenesis and identification of IFT20 as an interacting protein .
20558241	0	SPEM1	22,27	UBQLN1	0,6	SPEM1	UBQLN1	74288(Tax:10090)	56085(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	UBQLN1 interacts with SPEM1 and participates in spermiogenesis .
22258533	0	SPG30	28,33	KIF1A	0,5	SPG30	KIF1A	547	547	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	KIF1A missense mutations in SPG30 , an autosomal_recessive_spastic_paraplegia : distinct phenotypes according to the nature of the mutations .
18644145	0	SPG31	85,90	REEP1	73,78	SPG31	REEP1	65055	65055	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Autosomal_dominant_hereditary_spastic_paraplegia : novel mutations in the REEP1 gene -LRB- SPG31 -RRB- .
21618648	0	SPG31	19,24	REEP1	0,5	SPG31	REEP1	65055	65055	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	REEP1 mutations in SPG31 : frequency , mutational spectrum , and potential association with mitochondrial_morpho-functional_dysfunction .
12552568	0	SPG4	94,98	Spastin	100,107	SPG4	Spastin	6683	6683	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Screening of patients with hereditary_spastic_paraplegia reveals seven novel mutations in the SPG4 -LRB- Spastin -RRB- gene .
11723204	0	SPG4	97,101	spastin	88,95	SPG4	spastin	6683	6683	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A large family with hereditary_spastic_paraparesis due to a frame shift mutation of the spastin -LRB- SPG4 -RRB- gene : association with multiple_sclerosis in two affected siblings and epilepsy in other affected family members .
20461110	0	SPG42	113,118	SLC33A1	99,106	SPG42	SLC33A1	9197	9197	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A total of 220 patients with autosomal_dominant_spastic_paraplegia do not display mutations in the SLC33A1 gene -LRB- SPG42 -RRB- .
23269439	0	SPG7	32,36	paraplegin	38,48	SPG7	paraplegin	6687	6687	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The p.Ala510Val mutation in the SPG7 -LRB- paraplegin -RRB- gene is the most common mutation causing adult onset neurogenetic_disease in patients of British ancestry .
23455931	0	SPG8	80,84	KIAA0196	70,78	SPG8	KIAA0196	9897	9897	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Pure adult-onset spastic_paraplegia caused by a novel mutation in the KIAA0196 -LRB- SPG8 -RRB- gene .
21936950	0	SPHK1	39,44	sphingosine_kinase-1	17,37	SPHK1	sphingosine kinase-1	8877	8877	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	An novel role of sphingosine_kinase-1 -LRB- SPHK1 -RRB- in the invasion and metastasis of esophageal_carcinoma .
26549227	0	SPHK1	85,90	sphingosine_kinase_1	63,83	SPHK1	sphingosine kinase 1	8877	8877	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	MiR-506 suppresses liver_cancer angiogenesis through targeting sphingosine_kinase_1 -LRB- SPHK1 -RRB- mRNA .
12459275	0	SPI-C	27,32	SPI-C	87,92	SPI-C	SPI-C	20728(Tax:10090)	121599	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C .
12459275	0	SPI-C	87,92	SPI-C	27,32	SPI-C	SPI-C	121599	20728(Tax:10090)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Genomic structure of mouse SPI-C and genomic structure and expression pattern of human SPI-C .
2338340	0	SPI1	35,39	p11	65,68	SPI1	p11	6688	6281	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the human oncogene SPI1 on chromosome 11 , region p11 .22 .
16253999	0	SPIN90	15,21	Arp2/3	31,37	SPIN90	Arp2/3	51517	10097;10096	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation .
22699143	0	SPINK1	81,87	PRSS1	45,50	SPINK1	PRSS1	6690	5644	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis .
16823394	0	SPINK1	85,91	pancreatic_secretory_trypsin_inhibitor	45,83	SPINK1	pancreatic secretory trypsin inhibitor	6690	6690	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of a large genomic deletion in the pancreatic_secretory_trypsin_inhibitor -LRB- SPINK1 -RRB- gene .
15980664	0	SPINK1	57,63	serine_protease_inhibitor_Kazal_Type_1	17,55	SPINK1	serine protease inhibitor Kazal Type 1	6690	6690	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the serine_protease_inhibitor_Kazal_Type_1 -LRB- SPINK1 -RRB- gene in Japanese patients with pancreatitis .
20543535	0	SPINK1	107,113	serine_protease_inhibitor_Kazal_type_1	67,105	SPINK1	serine protease inhibitor Kazal type 1	6690	6690	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Phenotypic variability of the homozygous IVS3 +2 T > C mutation in the serine_protease_inhibitor_Kazal_type_1 -LRB- SPINK1 -RRB- gene in patients with chronic pancreatitis .
22673501	0	SPINK1	61,67	serine_protease_inhibitor_Kazal_type_1	21,59	SPINK1	serine protease inhibitor Kazal type 1	6690	6690	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The NS34 mutation of serine_protease_inhibitor_Kazal_type_1 -LRB- SPINK1 -RRB- gene and alcoholic_chronic_pancreatitis .
22212898	0	SPINK6	109,115	serine_proteinase_inhibitor_Kazal-type_6	67,107	SPINK6	serine proteinase inhibitor Kazal-type 6	404203	404203	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression , purification and characterization of recombinant human serine_proteinase_inhibitor_Kazal-type_6 -LRB- SPINK6 -RRB- in Pichia_pastoris .
15930277	0	SPINT2	109,115	hepatocyte_growth_factor_activator_inhibitor_type_2	57,108	SPINT2	hepatocyte growth factor activator inhibitor type 2	10653	10653	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Tumor suppressor activity and epigenetic inactivation of hepatocyte_growth_factor_activator_inhibitor_type_2 / SPINT2 in papillary and clear_cell_renal_cell_carcinoma .
21899893	0	SPLUNC1	51,58	TLR2	30,34	SPLUNC1	TLR2	51297	7097	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	MAPK/AP -1 activation mediates TLR2 agonist-induced SPLUNC1 expression in human lung epithelial cells .
17018031	0	SPO11-1	35,42	SPO11-2	12,19	SPO11-1	SPO11-2	7009000(Tax:10685)	7009001(Tax:10685)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination .
17018031	0	SPO11-2	12,19	SPO11-1	35,42	SPO11-2	SPO11-1	7009001(Tax:10685)	7009000(Tax:10685)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination .
18997279	0	SPOP	44,48	speckle-type_POZ_protein	18,42	SPOP	speckle-type POZ protein	8405	8405	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	BTB/POZ domain of speckle-type_POZ_protein -LRB- SPOP -RRB- confers proapoptotic function in HeLa cells .
12972007	0	SPP	60,63	signal_peptide_peptidase	34,58	SPP	signal peptide peptidase	14950(Tax:10090)	14950(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the presenilin-like signal_peptide_peptidase -LRB- SPP -RRB- in mouse adult brain and during development .
24768597	0	SPP	40,43	signal_peptide_peptidase	14,38	SPP	signal peptide peptidase	81502	81502	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|nmod|END_ENTITY	Inhibitors of signal_peptide_peptidase -LRB- SPP -RRB- affect HSV-1 infectivity in vitro and in vivo .
22276228	0	SPP1	34,38	Osteopontin	16,27	SPP1	Osteopontin	6696	6696	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Polymorphism in Osteopontin Gene -LRB- SPP1 -RRB- Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population .
22261033	0	SPP1	42,46	osteopontin	29,40	SPP1	osteopontin	6696	6696	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Cigarette smoke induction of osteopontin -LRB- SPP1 -RRB- mediates T -LRB- H -RRB- 17 inflammation in human and experimental emphysema .
23784265	0	SPP1	55,59	osteopontin	37,48	SPP1	osteopontin	6696	6696	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between polymorphisms in osteopontin gene -LRB- SPP1 -RRB- and first episode calcium_oxalate urolithiasis .
15062857	0	SPP2	63,67	secreted_phosphoprotein_24	30,56	SPP2	secreted phosphoprotein 24	6694	281500(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the human secreted_phosphoprotein_24 gene -LRB- SPP2 -RRB- and comparison of the protein sequence in nine species .
15241655	0	SPR	79,82	sepiapterin_reductase	51,72	SPR	sepiapterin reductase	6697	6697	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Heterozygous mutation in 5 ' - untranslated region of sepiapterin_reductase gene -LRB- SPR -RRB- in a patient with dopa-responsive_dystonia .
12823445	0	SPR1	0,4	HLA-C	15,20	SPR1	HLA-C	170680	3107	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	SPR1 gene near HLA-C is unlikely to be a psoriasis susceptibility gene .
17537256	0	SPRN	79,83	Shadow_of_Prion_Protein	54,77	SPRN	Shadow of Prion Protein	100302330(Tax:9940)	100302330(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the genomic region containing the Shadow_of_Prion_Protein -LRB- SPRN -RRB- gene in sheep .
19917049	0	SPRN	70,74	Shadow_of_prion_protein	45,68	SPRN	Shadow of prion protein	100302330(Tax:9940)	100302330(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of polymorphisms in the ovine Shadow_of_prion_protein -LRB- SPRN -RRB- gene and assessment of their effect on promoter activity and susceptibility for classical scrapie .
22367317	0	SPRN	17,21	shadow_of_prion_protein_homology	23,55	SPRN	shadow of prion protein homology	100302330(Tax:9940)	100302330(Tax:9940)	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms of SPRN -LRB- shadow_of_prion_protein_homology -RRB- in three breeds of sheep in China .
12091247	0	SPRR1B	54,60	BMK1	0,4	SPRR1B	BMK1	6699	5598	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	BMK1 -LRB- ERK5 -RRB- regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells .
22731250	0	SPRR2A	0,6	HDAC1	42,47	SPRR2A	HDAC1	6700	3065	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity .
10940627	0	SPRY2	6,11	FGF2	21,25	SPRY2	FGF2	10253	2247	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Human SPRY2 inhibits FGF2 signalling by a secreted factor .
22311084	0	SPS-1	109,114	selenoprotein_W	26,41	SPS-1	selenoprotein W	426612(Tax:9031)	100310814(Tax:9031)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of chicken selenoprotein_W , selenocysteine-synthase -LRB- SecS -RRB- , and selenophosphate_synthetase-1 -LRB- SPS-1 -RRB- in CHO-K1 cells .
18036521	0	SPT16	62,67	MKL1	73,77	SPT16	MKL1	11198	57591	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of SRF-dependent gene expression by association of SPT16 with MKL1 .
10454543	0	SPT5	48,52	RAP30	32,37	SPT5	RAP30	6829	2963	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Tat-SF1 protein associates with RAP30 and human SPT5 proteins .
7760849	0	SPT6	51,55	estrogen_receptor	21,38	SPT6	estrogen receptor	6830	2099	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Enhancement of human estrogen_receptor activity by SPT6 : a potential coactivator .
8275706	0	SPTAN1	45,51	alpha-fodrin	26,38	SPTAN1	alpha-fodrin	6709	6709	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Localization of the human alpha-fodrin gene -LRB- SPTAN1 -RRB- to 9q33 -- > q34 by fluorescence in situ hybridization .
25096061	0	SPTBN1	39,45	ATF3	110,114	SPTBN1	ATF3	6711	467	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2 .
25096061	0	SPTBN1	39,45	STAT3	30,35	SPTBN1	STAT3	6711	6774	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2 .
17940722	0	SPTBN2	17,23	SCA5	25,29	SPTBN2	SCA5	6712	6712	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Screening of the SPTBN2 -LRB- SCA5 -RRB- gene in German SCA patients .
18484747	0	SPTLC1	0,6	ABCA1	13,18	SPTLC1	ABCA1	10558	19	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter .
25271326	0	SPX1	0,4	PHOSPHATE_STARVATION_RESPONSE_1	43,74	SPX1	PHOSPHATE STARVATION RESPONSE 1	832137(Tax:3702)	828979(Tax:3702)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	SPX1 is a phosphate-dependent inhibitor of PHOSPHATE_STARVATION_RESPONSE_1 in Arabidopsis .
20942275	0	SP_6	38,42	pain	68,72	SP 6	SP 6	80320	80320	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect on moxibustion at Sanyinjiao -LRB- SP_6 -RRB- for uterine contraction pain in labor : a randomized controlled trial -RSB- .
23444385	0	SQL-1	0,5	GMAP210	38,45	SQL-1	GMAP210	190949(Tax:6239)	9321	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	SQL-1 , homologue of the Golgi protein GMAP210 , modulates intraflagellar transport in C. _ elegans .
15493999	0	SQSTM1	75,81	p62	83,86	SQSTM1	p62	8878	8878	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Structural and functional studies of mutations affecting the UBA domain of SQSTM1 -LRB- p62 -RRB- which cause Paget 's _ disease_of_bone .
21908611	0	SQUINT	39,45	Hsp90	49,54	SQUINT	Hsp90	816074(Tax:3702)	855836(Tax:4932)	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Binding of the cyclophilin_40 ortholog SQUINT to Hsp90 protein is required for SQUINT function in Arabidopsis .
12238639	0	SR-A	70,74	CD36	37,41	SR-A	CD36	4481	948	Gene	Gene	increased|nmod|START_ENTITY increased|dobj|expression expression|nmod|END_ENTITY	Synergically increased expression of CD36 , CLA-1 and CD68 , but not of SR-A and LOX-1 , with the progression to foam cells from macrophages .
21736734	0	SR-A	0,4	SR-A	43,47	SR-A	SR-A	20288(Tax:10090)	20288(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38_MAPK activation .
21736734	0	SR-A	43,47	SR-A	0,4	SR-A	SR-A	20288(Tax:10090)	20288(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	SR-A ligand and M-CSF dynamically regulate SR-A expression and function in primary macrophages via p38_MAPK activation .
9548586	0	SR-A	74,78	scavenger_receptor	54,72	SR-A	scavenger receptor	4481	4481	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A naturally occurring isoform of the human macrophage scavenger_receptor -LRB- SR-A -RRB- gene generated by alternative splicing blocks modified LDL uptake .
22984960	0	SR-BI	0,5	ABCG1	22,27	SR-BI	ABCG1	100736552	100759619	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3 .
15894808	0	SR-BI	34,39	Angiotensin_II	0,14	SR-BI	Angiotensin II	25073(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY down-regulates|dobj|receptor down-regulates|nsubj|END_ENTITY	Angiotensin_II down-regulates the SR-BI HDL receptor in proximal tubular cells .
14729860	0	SR-BI	74,79	ApoA-II	0,7	SR-BI	ApoA-II	20778(Tax:10090)	11807(Tax:10090)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	ApoA-II modulates the association of HDL with class B scavenger receptors SR-BI and CD36 .
16185081	0	SR-BI	0,5	ApoE	72,76	SR-BI	ApoE	949	348	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE .
26322923	0	SR-BI	97,102	ApoE	74,78	SR-BI	ApoE	20778(Tax:10090)	11816(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Deficient|nmod|Expression Deficient|compound|END_ENTITY	Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial_Infarction Caused by Coronary_Atherosclerosis .
11561009	0	SR-BI	51,56	CD36	36,40	SR-BI	CD36	949	948	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of the lipid receptors CD36 and CLA-1 / SR-BI in the human gastrointestinal tract : towards the identification of receptors mediating the intestinal absorption of dietary lipids .
25389062	0	SR-BI	115,120	CD36	74,78	SR-BI	CD36	949	948	Gene	Gene	Expression|nmod|START_ENTITY Foam|dep|Expression Foam|dep|Expression Expression|nmod|END_ENTITY	Icariin Inhibits Foam Cell Formation By Down-Regulating the Expression of CD36 and Up-Regulating the Expression of SR-BI .
23894648	0	SR-BI	94,99	apolipoprotein_A-I	6,24	SR-BI	apolipoprotein A-I	949	335	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Human apolipoprotein_A-I is associated with dengue_virus_and_enhances_virus_infection through SR-BI .
12801960	0	SR-BI	64,69	scavenger_receptor_class_B_type_I	29,62	SR-BI	scavenger receptor class B type I	20778(Tax:10090)	20778(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation of scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- in gall bladder epithelium .
12809509	0	SR-BI	71,76	scavenger_receptor_class_B_type_I	36,69	SR-BI	scavenger receptor class B type I	20778(Tax:10090)	949	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of human and mouse hepatic scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- in the selective uptake of low-density lipoprotein-cholesteryl_esters .
14592533	0	SR-BI	47,52	scavenger_receptor_class_B_type_I	12,45	SR-BI	scavenger receptor class B type I	949	949	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- in lipid trafficking .
24738490	0	SR-BI	81,86	scavenger_receptor_class_B_type_I	46,79	SR-BI	scavenger receptor class B type I	949	949	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	The age effect on the association between the scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- polymorphism and HDL-C level : Tehran_Lipid_and_Glucose_Study .
8969220	0	SR-BI	106,111	scavenger_receptor_class_B_type_I	71,104	SR-BI	scavenger receptor class B type I	20778(Tax:10090)	20778(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- , a high density lipoprotein receptor , in steroidogenic cells of the murine adrenal gland .
11795294	0	SR-PSOX	82,89	scavenger_receptor_for_phosphatidylserine_and_oxidized_lipoprotein	14,80	SR-PSOX	scavenger receptor for phosphatidylserine and oxidized lipoprotein	58191	58191	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of scavenger_receptor_for_phosphatidylserine_and_oxidized_lipoprotein -LRB- SR-PSOX -RRB- in human atheroma .
16762838	0	SRA	15,18	SLIRP	0,5	SRA	SLIRP	10011	81892	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	SLIRP , a small SRA binding protein , is a nuclear receptor corepressor .
26496121	0	SRA	71,74	Steroid_Receptor_RNA_Activator	39,69	SRA	Steroid Receptor RNA Activator	10011	10011	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of the Long Non-coding RNA Steroid_Receptor_RNA_Activator -LRB- SRA -RRB- with TrxG and PRC2 Complexes .
18772891	0	SRA	42,45	UHRF1	54,59	SRA	UHRF1	4481	29128	Gene	Gene	protein|compound|START_ENTITY DNA|nmod|protein Recognition|nmod|DNA END_ENTITY|nsubj|Recognition	Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism .
26368281	0	SRA	52,55	UHRF1	66,71	SRA	UHRF1	4481	29128	Gene	Gene	Domain|compound|START_ENTITY Domain|nmod|END_ENTITY	Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine .
24253042	0	SRA	92,95	Uhrf1	135,140	SRA	Uhrf1	4481	29128	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated -LRB- SRA -RRB- domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA .
20219889	0	SRA	126,129	steroid_receptor_RNA_activator	94,124	SRA	steroid receptor RNA activator	10011	10011	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Research resource : expression profiling reveals unexpected targets and functions of the human steroid_receptor_RNA_activator -LRB- SRA -RRB- gene .
23907597	0	SRAP	40,44	Steroid_receptor_RNA_activator_protein	0,38	SRAP	Steroid receptor RNA activator protein	10011	10011	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Steroid_receptor_RNA_activator_protein -LRB- SRAP -RRB- expression as a prognostic factor in ER + human breast_tumors .
24549717	0	SRBI	104,108	CD81	97,101	SRBI	CD81	949	975	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Generation of infectious HCV pseudo typed particles and its utilization for studying the role of CD81 _ SRBI receptors in HCV_infection .
27028864	0	SRC	28,31	Androgen_receptor	0,17	SRC	Androgen receptor	6714	367	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Androgen_receptor regulates SRC expression through microRNA-203 .
18474606	0	SRC	0,3	Bif-1	28,33	SRC	Bif-1	20779(Tax:10090)	268294(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis .
17488714	0	SRC	0,3	Cas	13,16	SRC	Cas	6714	9564	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|END_ENTITY	SRC utilizes Cas to block gap junctional communication mediated by connexin43 .
17018524	0	SRC	0,3	Csk	92,95	SRC	Csk	6714	1445	Gene	Gene	phosphorylation|compound|START_ENTITY limited|nsubjpass|phosphorylation limited|nmod|changes changes|nmod|END_ENTITY	SRC tail phosphorylation is limited by structural changes in the regulatory tyrosine kinase Csk .
17967179	0	SRC	27,30	HGF	44,47	SRC	HGF	6714	3082	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A novel activating role of SRC and STAT3 on HGF transcription in human breast_cancer cells .
23563312	0	SRC	39,42	HIF1a	0,5	SRC	HIF1a	20779(Tax:10090)	15251(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	HIF1a and HIF2a independently activate SRC to promote melanoma metastases .
18381431	0	SRC	32,35	Id1	14,17	SRC	Id1	6714	3397	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of Id1 expression by SRC : implications for targeting of the bone morphogenetic protein pathway in cancer .
25579995	0	SRC	33,36	PXR	124,127	SRC	PXR	6714	8856	Gene	Gene	Binding|compound|START_ENTITY Adnectins|dep|Binding Adnectins|dep|Approach Approach|nmod|Promiscuity Promiscuity|nmod|END_ENTITY	Developing Adnectins That Target SRC Co-Activator Binding to PXR : A Structural Approach toward Understanding Promiscuity of PXR .
25579995	0	SRC	33,36	PXR	61,64	SRC	PXR	6714	8856	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Developing Adnectins That Target SRC Co-Activator Binding to PXR : A Structural Approach toward Understanding Promiscuity of PXR .
17602621	0	SRC	76,79	androgen_receptor	53,70	SRC	androgen receptor	6714	367	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|ligands ligands|nmod|association association|nmod|END_ENTITY	Nongenomic activity of ligands in the association of androgen_receptor with SRC .
15342401	0	SRC	0,3	epidermal_growth_factor_receptor	27,59	SRC	epidermal growth factor receptor	20779(Tax:10090)	13649(Tax:10090)	Gene	Gene	kinases|compound|START_ENTITY mediate|nsubj|kinases mediate|ccomp|ligand ligand|nsubj|END_ENTITY	SRC family kinases mediate epidermal_growth_factor_receptor ligand cleavage , proliferation , and invasion of head_and_neck_cancer cells .
15381832	0	SRC	125,128	epidermal_growth_factor_receptor	146,178	SRC	epidermal growth factor receptor	6714	1956	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal_growth_factor_receptor transactivation .
15985706	0	SRC	108,111	epidermal_growth_factor_receptor	129,161	SRC	epidermal growth factor receptor	6714	1956	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal_growth_factor_receptor transactivation .
12595559	0	SRC	22,25	hnRNP_K	62,69	SRC	hnRNP K	6714	3190	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Identification of the SRC pyrimidine-binding protein -LRB- SPy -RRB- as hnRNP_K : implications in the regulation of SRC1A transcription .
16103072	0	SRC	27,30	interleukin-8	40,53	SRC	interleukin-8	6714	3576	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Expression and activity of SRC regulate interleukin-8 expression in pancreatic_adenocarcinoma cells : implications for angiogenesis .
21785466	0	SRC	30,33	p27	97,100	SRC	p27	20779(Tax:10090)	12576(Tax:10090)	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|xcomp|induce induce|nmod|stabilization stabilization|amod|END_ENTITY	New pyrazolo -LSB- 3,4-d -RSB- pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization .
20123990	0	SRC	0,3	podoplanin	12,22	SRC	podoplanin	20779(Tax:10090)	14726(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	SRC induces podoplanin expression to promote cell migration .
16397019	0	SRC	124,127	stat3	14,19	SRC	stat3	6714	6774	Gene	Gene	levels|nmod|START_ENTITY associated|nmod|levels associated|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of stat3 in primary tumors from high-risk breast_cancer patients is associated with elevated levels of activated SRC and survivin expression .
15452162	0	SRC-1	110,115	HER2	39,43	SRC-1	HER2	6714	2064	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of SRC-1 , AIB1 , and PEA3 in HER2 mediated endocrine resistant breast_cancer ; a predictive role for SRC-1 .
15452162	0	SRC-1	14,19	HER2	39,43	SRC-1	HER2	6714	2064	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of SRC-1 , AIB1 , and PEA3 in HER2 mediated endocrine resistant breast_cancer ; a predictive role for SRC-1 .
15452162	0	SRC-1	110,115	SRC-1	14,19	SRC-1	SRC-1	6714	6714	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of SRC-1 , AIB1 , and PEA3 in HER2 mediated endocrine resistant breast_cancer ; a predictive role for SRC-1 .
15452162	0	SRC-1	14,19	SRC-1	110,115	SRC-1	SRC-1	6714	6714	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of SRC-1 , AIB1 , and PEA3 in HER2 mediated endocrine resistant breast_cancer ; a predictive role for SRC-1 .
12138096	0	SRC-1	85,90	STAT6	48,53	SRC-1	STAT6	8648	6778	Gene	Gene	recruitment|nmod|START_ENTITY mediates|dobj|recruitment mediates|nsubj|motif motif|nmod|domain domain|nmod|END_ENTITY	An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1 / SRC-1 .
14757047	0	SRC-1	24,29	STAT6	75,80	SRC-1	STAT6	8648	6778	Gene	Gene	domain|compound|START_ENTITY bound|nsubj|domain bound|nmod|motif motif|nmod|domain domain|compound|END_ENTITY	Structure of the NCoA-1 / SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain .
14993689	0	SRC-1	71,76	STAT6	122,127	SRC-1	STAT6	8648	6778	Gene	Gene	domain|compound|START_ENTITY bound|nsubj|domain bound|nmod|motif motif|nmod|domain domain|compound|END_ENTITY	Crystallization and preliminary crystallographic studies of the NCoA-1 / SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain .
21148148	0	SRC-1	43,48	STAT6	15,20	SRC-1	STAT6	8648	6778	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of STAT6 with its co-activator SRC-1 / NCoA-1 is regulated by dephosphorylation of the latter via PP2A .
16024786	0	SRC-1	0,5	UNC-5	15,20	SRC-1	UNC-5	171722(Tax:6239)	177334(Tax:6239)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	SRC-1 mediates UNC-5 signaling in Caenorhabditis_elegans .
8855229	0	SRC-1	41,46	p300	71,75	SRC-1	p300	8648	2033	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The nuclear hormone receptor coactivator SRC-1 is a specific target of p300 .
11196413	0	SRC-1	62,67	steroid_receptor_coactivator-1	30,60	SRC-1	steroid receptor coactivator-1	313929(Tax:10116)	313929(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of steroid_receptor_coactivator-1 -LRB- SRC-1 -RRB- in glucocorticoid action .
9506940	0	SRC-1	90,95	steroid_receptor_coactivator-1	58,88	SRC-1	steroid receptor coactivator-1	17977(Tax:10090)	17977(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Partial hormone resistance in mice with disruption of the steroid_receptor_coactivator-1 -LRB- SRC-1 -RRB- gene .
22011668	0	SRC-2	53,58	TIF-2	59,64	SRC-2	TIF-2	10499	10499	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|associated associated|nsubjpass|END_ENTITY	Sustained expression of steroid receptor coactivator SRC-2 / TIF-2 is associated with better prognosis in malignant_pleural_mesothelioma .
18922467	0	SRC-3	75,80	AIB1	81,85	SRC-3	AIB1	8202	8202	Gene	Gene	function|compound|START_ENTITY function|compound|END_ENTITY	Essential phosphatases and a phospho-degron are critical for regulation of SRC-3 / AIB1 coactivator function and turnover .
19433130	0	SRC-3	73,78	Akt	99,102	SRC-3	Akt	8202	207	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Gambogic_acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells .
24585635	0	SRC-3	57,62	VEGFR2	76,82	SRC-3	VEGFR2	8202	3791	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	ERK3 promotes endothelial cell functions by upregulating SRC-3 / SP1-mediated VEGFR2 expression .
19716257	0	SRC-3	44,49	steroid_receptor_coactivator-3	12,42	SRC-3	steroid receptor coactivator-3	8202	8202	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of steroid_receptor_coactivator-3 -LRB- SRC-3 -RRB- in human malignant_disease .
25772501	0	SRC-like_adaptor_protein	8,32	SLAP	34,38	SRC-like adaptor protein	SLAP	6503	6503	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of SRC-like_adaptor_protein -LRB- SLAP -RRB- in immune and malignant cell signaling .
12790809	0	SRC1	92,96	ERalpha	49,56	SRC1	ERalpha	10011	2099	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Transcriptional activation by estrogen receptor -LRB- ERalpha -RRB- and steroid_receptor_coactivator -LRB- SRC1 -RRB- involves distinct mechanisms in yeast and mammalian cells .
24586072	0	SRC1	12,16	SDF1	45,49	SRC1	SDF1	8648	6387	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	The role of SRC1 and SRC2 in steroid-induced SDF1 expression in normal and ectopic endometrium .
20432434	0	SRCAP	32,37	prostate_specific_antigen	62,87	SRCAP	prostate specific antigen	10847	354	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	The chromatin remodeling factor SRCAP modulates expression of prostate_specific_antigen and cellular proliferation in prostate_cancer cells .
26277787	0	SRCIN1	71,77	miR-211	0,7	SRCIN1	miR-211	80725	406993	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-211 promotes non-small cell lung_cancer proliferation by targeting SRCIN1 .
22257483	0	SRD5A1	26,32	5-alpha-reductase	0,17	SRD5A1	5-alpha-reductase	6715	6715	Gene	Gene	I|appos|START_ENTITY I|amod|END_ENTITY	5-alpha-reductase type I -LRB- SRD5A1 -RRB- is up-regulated in non-small cell lung_cancer but does not impact proliferation , cell cycle distribution or apoptosis .
16098368	0	SRD5A2	60,66	5-alpha_reductase	29,46	SRD5A2	5-alpha reductase	6716	6715	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	A novel missense mutation of 5-alpha_reductase type 2 gene -LRB- SRD5A2 -RRB- leads to severe male_pseudohermaphroditism in a Turkish family .
9208814	0	SRD5A2	111,117	5_alpha-reductase	80,97	SRD5A2	5 alpha-reductase	6716	6715	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Male pseudohermaphroditism resulting from a novel mutation in the human steroid 5_alpha-reductase type 2 gene -LRB- SRD5A2 -RRB- .
10081907	0	SRD5A2	25,31	5alpha-reductase	65,81	SRD5A2	5alpha-reductase	6716	6715	Gene	Gene	mutations|nmod|START_ENTITY locus|nsubj|mutations locus|xcomp|encoding encoding|dobj|END_ENTITY	Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate_cancer progression .
18268111	0	SRD5A2	56,62	5alpha-reductase	25,41	SRD5A2	5alpha-reductase	6716	6715	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	V89L polymorphism of the 5alpha-reductase Type II gene -LRB- SRD5A2 -RRB- , endogenous sex hormones , and prostate_cancer risk .
11303586	0	SRD5A2	73,79	CYP17	45,50	SRD5A2	CYP17	6716	1586	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The association between polymorphisms in the CYP17 and 5alpha-reductase -LRB- SRD5A2 -RRB- genes and serum androgen concentrations in men .
11340572	0	SRD5A2	113,119	cytochrome_P-450	50,66	SRD5A2	cytochrome P-450	6716	1586	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Impact of genetic polymorphisms of 17-hydroxylase cytochrome_P-450 -LRB- CYP17 -RRB- and steroid_5alpha-reductase_type_II -LRB- SRD5A2 -RRB- genes on prostate-cancer risk among the Japanese population .
16018939	0	SRD5A2	77,83	steroid_5-alpha_reductase_type_II	42,75	SRD5A2	steroid 5-alpha reductase type II	6716	6716	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Associations between polymorphisms in the steroid_5-alpha_reductase_type_II -LRB- SRD5A2 -RRB- gene and benign_prostatic_hyperplasia and prostate_cancer .
23160874	0	SRD5B1	56,62	AKR1D1	64,70	SRD5B1	AKR1D1	6718	6718	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two neonatal cholestasis patients with mutations in the SRD5B1 -LRB- AKR1D1 -RRB- gene : diagnosis and bile_acid profiles during chenodeoxycholic_acid treatment .
23403193	0	SREBF1	58,64	Sterol_regulatory_element_binding_transcription_factor_1	0,56	SREBF1	Sterol regulatory element binding transcription factor 1	6720	6720	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Sterol_regulatory_element_binding_transcription_factor_1 -LRB- SREBF1 -RRB- polymorphism and milk fatty_acid composition .
16497987	0	SREBP	63,68	endothelial_nitric_oxide_synthase	8,41	SREBP	endothelial nitric oxide synthase	7555	4846	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of endothelial_nitric_oxide_synthase in the regulation of SREBP activation by oxidized phospholipids .
19533843	0	SREBP-1	77,84	17beta-hydroxysteroid_dehydrogenase_type_12	30,73	SREBP-1	17beta-hydroxysteroid dehydrogenase type 12	6720	51144	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of 17beta-hydroxysteroid_dehydrogenase_type_12 by SREBP-1 .
11101056	0	SREBP-1	46,53	ADD-1	40,45	SREBP-1	ADD-1	6720	118	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Ritonavir increases the level of active ADD-1 / SREBP-1 protein during adipogenesis .
17379603	0	SREBP-1	93,100	ChREBP	152,158	SREBP-1	ChREBP	6720	51085	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	HNF1alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP-1 and carbohydrate-response_element-binding_protein -LRB- ChREBP -RRB- activation .
17989724	0	SREBP-1	14,21	IGF-1	0,5	SREBP-1	IGF-1	6720	3479	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway .
17681345	0	SREBP-1	111,118	Urokinase_plasminogen_activator	0,31	SREBP-1	Urokinase plasminogen activator	6720	5328	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Urokinase_plasminogen_activator -LRB- uPA -RRB- stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner .
19323650	0	SREBP-1	44,51	caspase_7	6,15	SREBP-1	caspase 7	6720	840	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	Human caspase_7 is positively controlled by SREBP-1 and SREBP-2 .
17452746	0	SREBP-1	0,7	heme_oxygenase_1	36,52	SREBP-1	heme oxygenase 1	20787(Tax:10090)	15368(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	SREBP-1 regulates the expression of heme_oxygenase_1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma .
23239524	0	SREBP-1	42,49	mTOR	0,4	SREBP-1	mTOR	78968(Tax:10116)	21977(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	mTOR regulates fatty_infiltration through SREBP-1 and PPARy after a combined massive rotator cuff tear and suprascapular_nerve_injury in rats .
12048207	0	SREBP-1C	58,66	sterol-regulatory_element-binding_protein-1c	12,56	SREBP-1C	sterol-regulatory element-binding protein-1c	6720	6720	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Insulin and sterol-regulatory_element-binding_protein-1c -LRB- SREBP-1C -RRB- regulation of gene expression in 3T3-L1 adipocytes .
23515283	0	SREBP-1c	28,36	Clusterin	0,9	SREBP-1c	Clusterin	20787(Tax:10090)	12759(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Clusterin decreases hepatic SREBP-1c expression and lipid accumulation .
16787385	0	SREBP-1c	39,47	GLUT4	14,19	SREBP-1c	GLUT4	78968(Tax:10116)	25139(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of GLUT4 gene expression by SREBP-1c in adipocytes .
25109869	0	SREBP-1c	80,88	Insig-1	72,79	SREBP-1c	Insig-1	78968(Tax:10116)	64194(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	Silibinin protects b cells from glucotoxicity through regulation of the Insig-1 / SREBP-1c pathway .
22984430	0	SREBP-1c	20,28	Sirtuin_1	0,9	SREBP-1c	Sirtuin 1	20787(Tax:10090)	93759(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sirtuin_1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle .
21549685	0	SREBP-1c	0,8	clusterin	46,55	SREBP-1c	clusterin	6720	1191	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SREBP-1c regulates glucose-stimulated hepatic clusterin expression .
10947952	0	SREBP-1c	65,73	sterol_regulatory-element-binding_protein-1c	19,63	SREBP-1c	sterol regulatory-element-binding protein-1c	78968(Tax:10116)	78968(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Insulin effects on sterol_regulatory-element-binding_protein-1c -LRB- SREBP-1c -RRB- transcriptional activity in rat hepatocytes .
11371634	0	SREBP-1c	99,107	sterol_regulatory_element-binding_protein-1c	53,97	SREBP-1c	sterol regulatory element-binding protein-1c	6720	6720	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Unsaturated fatty_acids inhibit transcription of the sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene by antagonizing ligand-dependent activation of the LXR .
11171976	0	SREBP-1c	60,68	sterol_regulatory_element-binding_protein_1c	14,58	SREBP-1c	sterol regulatory element-binding protein 1c	78968(Tax:10116)	78968(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of sterol_regulatory_element-binding_protein_1c -LRB- SREBP-1c -RRB- mRNA in rat hepatoma cells requires endogenous LXR ligands .
22985732	0	SREBP-2	77,84	Acetoacetyl-CoA_synthetase	0,26	SREBP-2	Acetoacetyl-CoA synthetase	6721	65985	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	Acetoacetyl-CoA_synthetase , a ketone body-utilizing enzyme , is controlled by SREBP-2 and affects serum cholesterol levels .
22005015	0	SREBP-2	63,70	Akt	0,3	SREBP-2	Akt	6721	207	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Akt acutely activates the cholesterogenic transcription factor SREBP-2 .
26694996	0	SREBP-2	125,132	Insig-2	117,124	SREBP-2	Insig-2	6721	51141	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	Increase of circulating cholesterol in vitamin_D deficiency is linked to reduced vitamin_D_receptor activity via the Insig-2 / SREBP-2 pathway .
18602894	0	SREBP-2	66,73	LDL-receptor	25,37	SREBP-2	LDL-receptor	6721	3949	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Rapamycin down-regulates LDL-receptor expression independently of SREBP-2 .
20138239	0	SREBP-2	33,40	TM7SF2	14,20	SREBP-2	TM7SF2	6721	7108	Gene	Gene	promoter|nmod|START_ENTITY promoter|nummod|END_ENTITY	Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element , a GC-box , and an inverted CCAAT-box .
12083769	0	SREBP-2	0,7	squalene_epoxidase	67,85	SREBP-2	squalene epoxidase	6721	6713	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene_epoxidase .
16806080	0	SREBP-2	59,66	sterol_regulatory_element-binding_protein-2	14,57	SREBP-2	sterol regulatory element-binding protein-2	6721	6721	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Mechanisms of sterol_regulatory_element-binding_protein-2 -LRB- SREBP-2 -RRB- regulation of human prostasin gene expression .
26147081	0	SREBP1	75,81	CRTC2	21,26	SREBP1	CRTC2	20787(Tax:10090)	74343(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY controls|advcl|regulating controls|nsubj|END_ENTITY	The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1 .
25270091	0	SREBP1	53,59	SIRT1	0,5	SREBP1	SIRT1	6720	23411	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	SIRT1 promotes endometrial_tumor_growth by targeting SREBP1 and lipogenesis .
21871872	0	SREBP1	45,51	Sterol_regulatory_element_binding_protein-1	0,43	SREBP1	Sterol regulatory element binding protein-1	6720	6720	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Sterol_regulatory_element_binding_protein-1 -LRB- SREBP1 -RRB- activation in motor neurons in excitotoxicity and amyotrophic_lateral_sclerosis -LRB- ALS -RRB- : Indip , a potential therapeutic peptide .
26601584	0	SREBP1	18,24	sterol_regulatory_element_binding_protein_1	26,69	SREBP1	sterol regulatory element binding protein 1	100860908	100860908	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of SREBP1 -LRB- sterol_regulatory_element_binding_protein_1 -RRB- promotes de novo fatty_acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells .
21723501	0	SREBP1c	23,30	Akt	0,3	SREBP1c	Akt	20787(Tax:10090)	11651(Tax:10090)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways .
21806970	0	SREBP1c	30,37	S6K1	8,12	SREBP1c	S6K1	20787(Tax:10090)	72508(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of S6K1 in regulation of SREBP1c expression in the liver .
20847591	0	SREBP1c	14,21	mTOR	36,40	SREBP1c	mTOR	6720	21977(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of SREBP1c expression by mTOR signaling in hepatocytes .
21540177	0	SREBP1c	6,13	peroxisome_proliferator-activated_receptor_alpha	59,107	SREBP1c	peroxisome proliferator-activated receptor alpha	6720	5465	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Human SREBP1c expression in liver is directly regulated by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- .
26820367	0	SREBP2	63,69	PCSK9	49,54	SREBP2	PCSK9	6721	255738	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Is sEHi lowering LDL-C by reducing expression of PCSK9 through SREBP2 pathway ?
21084441	0	SREBP2	45,51	Sterol_regulatory_element-binding_protein_2	0,43	SREBP2	Sterol regulatory element-binding protein 2	20788(Tax:10090)	20788(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Sterol_regulatory_element-binding_protein_2 -LRB- SREBP2 -RRB- activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes .
24972343	0	SREBP2	153,159	sterol_regulatory_element_binding_protein_2	108,151	SREBP2	sterol regulatory element binding protein 2	6721	6721	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Lupin peptides lower low-density lipoprotein -LRB- LDL -RRB- cholesterol through an up-regulation of the LDL_receptor / sterol_regulatory_element_binding_protein_2 -LRB- SREBP2 -RRB- pathway at HepG2 cell line .
10570919	0	SREBP_cleavage-activating_protein	45,78	SCAP	80,84	SREBP cleavage-activating protein	SCAP	22937	22937	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A common Ile796Val polymorphism of the human SREBP_cleavage-activating_protein -LRB- SCAP -RRB- gene .
15057274	0	SRF	0,3	Bcl-2	14,19	SRF	Bcl-2	20807(Tax:10090)	12043(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development .
7600583	0	SRF	86,89	RhoA	23,27	SRF	RhoA	6722	387	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	The Rho family GTPases RhoA , Rac1 , and CDC42Hs regulate transcriptional activation by SRF .
20808827	0	SRF	67,70	frataxin	20,28	SRF	frataxin	6722	2395	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of human frataxin is regulated by transcription factors SRF and TFAP2 .
21329726	0	SRF	34,37	serum_response_factor	11,32	SRF	serum response factor	20807(Tax:10090)	20807(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of serum_response_factor -LRB- SRF -RRB- deletion on conditioned reinforcement .
7851904	0	SRF_accessory_protein_1	27,50	SAP1	21,25	SRF accessory protein 1	SAP1	2005	2005	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mapping of the human SAP1 -LRB- SRF_accessory_protein_1 -RRB- gene and SAP2 , a gene encoding a related protein , to chromosomal bands 1q32 and 12q23 , respectively .
24365151	0	SRG3	13,17	Wwp2	0,4	SRG3	Wwp2	6599	11060	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Wwp2 targets SRG3 , a scaffold protein of the SWI/SNF-like BAF complex , for ubiquitination and degradation .
21060114	0	SRGAP1	48,54	ROBO1	41,46	SRGAP1	ROBO1	57522	6091	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The corticofugal neuron-associated genes ROBO1 , SRGAP1 , and CTIP2 exhibit an anterior to posterior gradient of expression in early fetal human neocortex development .
7831767	0	SRP-1	28,33	NPI-1	0,5	SRP-1	NPI-1	3836	3836	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	NPI-1 , the human homolog of SRP-1 , interacts with influenza virus nucleoprotein .
25833951	0	SRP43	111,116	SRP54	12,17	SRP43	SRP54	5729233(Tax:3055)	5719106(Tax:3055)	Gene	Gene	Recruited|nmod|START_ENTITY Recruited|nsubjpass|END_ENTITY	Chloroplast SRP54 Was Recruited for Posttranslational Protein Transport via Complex Formation with Chloroplast SRP43 during Land Plant Evolution .
25833951	0	SRP54	12,17	SRP43	111,116	SRP54	SRP43	5719106(Tax:3055)	5729233(Tax:3055)	Gene	Gene	Recruited|nsubjpass|START_ENTITY Recruited|nmod|END_ENTITY	Chloroplast SRP54 Was Recruited for Posttranslational Protein Transport via Complex Formation with Chloroplast SRP43 during Land Plant Evolution .
25381816	0	SRPK1	34,39	Serine-arginine_protein_kinase_1	0,32	SRPK1	Serine-arginine protein kinase 1	6732	6732	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Serine-arginine_protein_kinase_1 -LRB- SRPK1 -RRB- inhibition as a potential novel targeted therapeutic strategy in prostate_cancer .
18718938	0	SRPX2	112,117	uPAR	158,162	SRPX2	uPAR	68792(Tax:10090)	18793(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Epileptic_and_developmental_disorders of the speech cortex : ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR .
23478443	0	SRSF1	28,33	p53	45,48	SRSF1	p53	6426	7157	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence .
26562302	0	SRSF2	40,45	IDH1	28,32	SRSF2	IDH1	6427	3417	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
26562302	0	SRSF2	40,45	IDH2	34,38	SRSF2	IDH2	6427	3418	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
26508027	0	SRSF2	52,57	SF3B1	45,50	SRSF2	SF3B1	6427	23451	Gene	Gene	ASXL1|nummod|START_ENTITY ASXL1|nummod|END_ENTITY	Genetic landscape of recurrent ASXL1 , U2AF1 , SF3B1 , SRSF2 , and EZH2 mutations in 304 Chinese patients with myelodysplastic_syndromes .
26562302	0	SRSF2	40,45	SF3B1	47,52	SRSF2	SF3B1	6427	23451	Gene	Gene	KRAS|appos|START_ENTITY KRAS|appos|END_ENTITY	Mutational Hotspot of TET2 , IDH1 , IDH2 , SRSF2 , SF3B1 , KRAS , and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast_Cell_Tumors .
26508027	0	SRSF2	52,57	U2AF1	38,43	SRSF2	U2AF1	6427	7307	Gene	Gene	ASXL1|nummod|START_ENTITY ASXL1|nummod|END_ENTITY	Genetic landscape of recurrent ASXL1 , U2AF1 , SF3B1 , SRSF2 , and EZH2 mutations in 304 Chinese patients with myelodysplastic_syndromes .
25234929	0	SRSF3	68,73	ORF57	115,120	SRSF3	ORF57	6428	4961525(Tax:37296)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi_sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing .
21592645	0	SRY	0,3	SOX9	20,24	SRY	SOX9	6736	6662	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nmod|END_ENTITY	SRY upregulation of SOX9 is inefficient and delayed , allowing ovarian differentiation , in the B6.Y -LRB- TIR -RRB- gonad .
22523547	0	SRY	22,25	Sox9	58,62	SRY	Sox9	6736	6662	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Synergistic effect of SRY and its direct target , WDR5 , on Sox9 expression .
22523547	0	SRY	22,25	WDR5	49,53	SRY	WDR5	6736	11091	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Synergistic effect of SRY and its direct target , WDR5 , on Sox9 expression .
11278460	0	SRY	31,34	WT1	57,60	SRY	WT1	6736	7490	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The human sex-determining gene SRY is a direct target of WT1 .
12970737	0	SRY	54,57	WT1	107,110	SRY	WT1	6736	7490	Gene	Gene	activity|nmod|START_ENTITY modulated|nsubjpass|activity modulated|nmod|product product|appos|END_ENTITY	Transcriptional activity of testis-determining factor SRY is modulated by the Wilms ' _ tumor_1 gene product , WT1 .
22815844	0	SRY	66,69	WT1	104,107	SRY	WT1	6736	7490	Gene	Gene	START_ENTITY|advcl|mutation mutation|compound|END_ENTITY	A 46 , XY female DSD patient with bilateral gonadoblastoma , a novel SRY missense mutation combined with a WT1 KTS splice-site mutation .
9879712	0	SRY	109,112	WT1	30,33	SRY	WT1	21674(Tax:10090)	22431(Tax:10090)	Gene	Gene	transfected|nmod|START_ENTITY line|acl|transfected function|nmod|line function|nsubj|gene gene|appos|END_ENTITY	Wilms ' _ tumor suppressor gene -LRB- WT1 -RRB- as a target gene of SRY function in a mouse ES cell line transfected with SRY .
9879712	0	SRY	55,58	WT1	30,33	SRY	WT1	21674(Tax:10090)	22431(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nmod|gene gene|appos|END_ENTITY	Wilms ' _ tumor suppressor gene -LRB- WT1 -RRB- as a target gene of SRY function in a mouse ES cell line transfected with SRY .
19211811	0	SRY	54,57	cerebellin_4_precursor	4,26	SRY	cerebellin 4 precursor	21674(Tax:10090)	228942(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	The cerebellin_4_precursor gene is a direct target of SRY and SOX9 in mice .
19661285	0	SRY	41,44	monoamine_oxidase_A	14,33	SRY	monoamine oxidase A	6736	4128	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of monoamine_oxidase_A by the SRY gene on the Y chromosome .
8239073	0	SRY	30,33	sex-determining_region_Y	4,28	SRY	sex-determining region Y	100625818	100625818	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The sex-determining_region_Y -LRB- SRY -RRB- gene is mapped to p12-p13 of the Y chromosome in pig -LRB- Sus_scrofa_domestica -RRB- by in situ hybridization .
8434602	0	SRY	130,133	sex-determining_region_Y	104,128	SRY	sex-determining region Y	6736	6736	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the transcriptional unit , structural organization , and promoter sequence of the human sex-determining_region_Y -LRB- SRY -RRB- gene , using a reverse genetic approach .
10428169	0	SRY	37,40	sex-determining_region_on_Y	8,35	SRY	sex-determining region on Y	6736	6736	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A novel sex-determining_region_on_Y -LRB- SRY -RRB- nonsense mutation identified in a 45 , X/47 , XYY female .
9093193	0	SRY	76,79	sex-determining_region_on_Y	47,74	SRY	sex-determining region on Y	6736	6736	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Paternal somatic and germ-line mosaicism for a sex-determining_region_on_Y -LRB- SRY -RRB- missense mutation leading to recurrent 46 , XY sex reversal .
22194602	0	SRY-box-containing_gene_2	0,25	Tlx	67,70	SRY-box-containing gene 2	Tlx	6657	4179	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	SRY-box-containing_gene_2 regulation of nuclear receptor tailless -LRB- Tlx -RRB- transcription in adult neural stem cells .
17055661	0	SRY-box_containing_gene_11	0,26	Sox11	28,33	SRY-box containing gene 11	Sox11	20666(Tax:10090)	20666(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	SRY-box_containing_gene_11 -LRB- Sox11 -RRB- transcription factor is required for neuron survival and neurite growth .
17525254	0	SRY-related_HMG_box_9	0,21	Col4a2	50,56	SRY-related HMG box 9	Col4a2	20682(Tax:10090)	12827(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	SRY-related_HMG_box_9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells .
19789211	0	SRm300	93,99	Cwc21	33,38	SRm300	Cwc21	23524	23524	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	A systematic characterization of Cwc21 , the yeast ortholog of the human spliceosomal protein SRm300 .
19582790	0	SRrp37	0,6	SC35	96,100	SRrp37	SC35	51329	6427	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SRrp37 , a novel splicing regulator located in the nuclear speckles and nucleoli , interacts with SC35 and modulates alternative pre-mRNA splicing in vivo .
8824709	0	SS-B	97,101	autoantigen_La	82,96	SS-B	autoantigen La	6741	6741	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of a murine autoreactive B cell by immunization with human recombinant autoantigen_La / SS-B : characterization of the autoepitope .
9016572	0	SS-B	40,44	autoantigen_La	24,38	SS-B	autoantigen La	6741	6741	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the autoantigen_La -LRB- SS-B -RRB- as a dsRNA unwinding enzyme .
9778034	0	SS-B	39,43	autoantigen_La	24,38	SS-B	autoantigen La	6741	6741	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of human autoantigen_La / SS-B as BC1/BC200 RNA-binding protein .
24768604	1	SS-B/La	105,112	Ro52	62,66	SS-B/La	Ro52	6741	6737	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	The detection of Ro52 and Ro60 according to the presence of SS-B/La , and ANA pattern and titer .
19040727	0	SSADH	80,85	succinate_semialdehyde_dehydrogenase	42,78	SSADH	succinate semialdehyde dehydrogenase	214579(Tax:10090)	214579(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Neurotransmitter alterations in embryonic succinate_semialdehyde_dehydrogenase -LRB- SSADH -RRB- deficiency suggest a heightened excitatory state during development .
12606817	0	SSAO	39,43	Semicarbazide-sensitive_amine_oxidase	0,37	SSAO	Semicarbazide-sensitive amine oxidase	11754(Tax:10090)	11754(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- gene expression in alloxan-induced diabetes in mice .
1899791	0	SSAO	48,52	Semicarbazide-sensitive_amine_oxidase	0,37	SSAO	Semicarbazide-sensitive amine oxidase	29473(Tax:10116)	29473(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Semicarbazide-sensitive_amine_oxidase activity -LRB- SSAO -RRB- of rat epididymal white adipose tissue .
10391401	0	SSAO	55,59	semicarbazide-sensitive_amine_oxidase	16,53	SSAO	semicarbazide-sensitive amine oxidase	314	314	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Elevated plasma semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity in Type_2_diabetes_mellitus complicated by retinopathy .
11042135	0	SSAO	72,76	semicarbazide-sensitive_amine_oxidase	33,70	SSAO	semicarbazide-sensitive amine oxidase	314	314	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Time-dependent activation of the semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- from ox lung microsomes .
12491790	0	SSAO	115,119	semicarbazide-sensitive_amine_oxidase	76,113	SSAO	semicarbazide-sensitive amine oxidase	314	314	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Various mammalian tissues contain cell membrane-bound amine oxidase termed semicarbazide-sensitive_amine_oxidase -LRB- SSAO , EC 1.4.3.6 -RRB- -RSB- .
14697907	0	SSAO	78,82	semicarbazide-sensitive_amine_oxidase	39,76	SSAO	semicarbazide-sensitive amine oxidase	314	314	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Selective inhibitors of membrane-bound semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity in mammalian tissues .
15456951	0	SSAO	45,49	semicarbazide-sensitive_amine_oxidase	6,43	SSAO	semicarbazide-sensitive amine oxidase	314	314	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Serum semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity correlates with VEGF in non-small-cell lung_cancer patients .
16487546	0	SSAO	52,56	semicarbazide-sensitive_amine_oxidase	13,50	SSAO	semicarbazide-sensitive amine oxidase	314	314	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Diabetes and semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity : a review .
16524643	0	SSAO	47,51	semicarbazide-sensitive_amine_oxidase	8,45	SSAO	semicarbazide-sensitive amine oxidase	29473(Tax:10116)	29473(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Soluble semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity is related to oxidative stress and subchronic_inflammation in streptozotocin-induced diabetic rats .
17286756	0	SSB	81,84	calpastatin	86,97	SSB	calpastatin	6741	831	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Clinical significance of autoantibodies recognizing Sj gren 's syndrome A -LRB- SSA -RRB- , SSB , calpastatin and alpha-fodrin in primary Sj gren 's syndrome .
11854290	0	SSB	126,129	single-stranded_DNA-binding_protein	89,124	SSB	single-stranded DNA-binding protein	20466802	20466802	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Complete inhibition of Streptococcus_pneumoniae RecA protein-catalyzed ATP hydrolysis by single-stranded_DNA-binding_protein -LRB- SSB protein -RRB- : implications for the mechanism of SSB protein-stimulated DNA strand exchange .
26495868	0	SSBP3	0,5	Islet-1	21,28	SSBP3	Islet-1	72475(Tax:10090)	16392(Tax:10090)	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic b-Cell Target Genes .
9789053	0	SSI-1	26,31	JAB	39,42	SSI-1	JAB	8651	8651	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Three distinct domains of SSI-1 / SOCS-1 / JAB protein are required for its suppression of interleukin_6 signaling .
9789053	0	SSI-1	26,31	SOCS-1	32,38	SSI-1	SOCS-1	8651	8651	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Three distinct domains of SSI-1 / SOCS-1 / JAB protein are required for its suppression of interleukin_6 signaling .
10199952	0	SSRP1	20,25	CHD1	0,4	SSRP1	CHD1	6749	1105	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin .
12571244	0	SSRP1	73,78	CK2	15,18	SSRP1	CK2	542007(Tax:4577)	100384477(Tax:4577)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Protein kinase CK2 phosphorylates the high mobility group domain protein SSRP1 , inducing the recognition of UV-damaged DNA .
11344167	0	SSRP1	21,26	SSRP1	72,77	SSRP1	SSRP1	6749	6749	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of FACT , SSRP1 , and the high mobility group -LRB- HMG -RRB- domain of SSRP1 with DNA damaged by the anticancer drug cisplatin .
11344167	0	SSRP1	72,77	SSRP1	21,26	SSRP1	SSRP1	6749	6749	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of FACT , SSRP1 , and the high mobility group -LRB- HMG -RRB- domain of SSRP1 with DNA damaged by the anticancer drug cisplatin .
12374749	0	SSRP1	0,5	p63	67,70	SSRP1	p63	6749	8626	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	SSRP1 functions as a co-activator of the transcriptional activator p63 .
20140708	0	SSTR1	99,104	Somatostatin	60,72	SSTR1	Somatostatin	102172207	102170466	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization and polymorphisms of the caprine Somatostatin -LRB- SST -RRB- and SST Receptor 1 -LRB- SSTR1 -RRB- genes that are linked with growth traits .
7777168	0	SSTR1	26,31	somatostatin	42,54	SSTR1	somatostatin	25033(Tax:10116)	24797(Tax:10116)	Gene	Gene	subtypes|compound|START_ENTITY subtypes|compound|END_ENTITY	Patterns of expression of SSTR1 and SSTR2 somatostatin receptor subtypes in the hypothalamus of the adult rat : relationship to neuroendocrine function .
7669056	0	SSTR2	14,19	Somatostatin	0,12	SSTR2	Somatostatin	54305(Tax:10116)	24797(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Somatostatin -LRB- SSTR2 -RRB- receptors mediate phospholipase C-independent Ca2 + mobilization in rat AR42J pancreas cells .
9045884	1	SSTR2	98,103	growth_hormone	118,132	SSTR2	growth hormone	6752	2688	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of SSTR2 and SSTR5 for growth_hormone , thyroid-stimulating hormone , and prolactin regulation .
10604740	0	SSTR2	149,154	somatostatin_receptor_2	125,148	SSTR2	somatostatin receptor 2	6752	6752	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma , but does not involve mutations in the somatostatin_receptor_2 -LRB- SSTR2 -RRB- gene at 17q24 .
18521573	0	SSTR4	12,17	somatostatin	18,30	SSTR4	somatostatin	20608(Tax:10090)	20604(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Hippocampal SSTR4 somatostatin receptors control the selection of memory strategies .
16601280	0	SSTR5	33,38	Somatostatin_receptor_subtype_5	0,31	SSTR5	Somatostatin receptor subtype 5	6755	6755	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Somatostatin_receptor_subtype_5 -LRB- SSTR5 -RRB- mRNA expression is related to histopathological features of cell proliferation in insulinomas .
12192619	0	SSTR5	52,57	somatostatin_receptor_5	27,50	SSTR5	somatostatin receptor 5	6755	6755	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel polymorphisms in the somatostatin_receptor_5 -LRB- SSTR5 -RRB- gene associated with bipolar_affective_disorder .
12898583	0	SSTR5	80,85	somatostatin_receptor_5	55,78	SSTR5	somatostatin receptor 5	6755	6755	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of transmission of novel polymorphisms in the somatostatin_receptor_5 -LRB- SSTR5 -RRB- gene in patients with autism .
21693197	0	SSTR_2	82,88	somatostatin_receptor_subtype_2	49,80	SSTR 2	somatostatin receptor subtype 2	100499615	100499615	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Isolation , characterization , and distribution of somatostatin_receptor_subtype_2 -LRB- SSTR_2 -RRB- mRNA in rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- , and regulation of its expression by glucose .
17186289	0	SSX-1	58,63	CD4	14,17	SSX-1	CD4	6756	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Assessment of CD4 + T cells specific for the tumor antigen SSX-1 in cancer-free individuals .
24356449	0	SSX2IP	39,45	Cep290	54,60	SSX2IP	Cep290	117178	80184	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone .
11799143	0	SSeCKS	48,54	Src-suppressed_C_kinase_substrate	13,46	SSeCKS	Src-suppressed C kinase substrate	83397(Tax:10090)	83397(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of Src-suppressed_C_kinase_substrate -LRB- SSeCKS -RRB- in vascular endothelial cells by bacterial lipopolysaccharide .
22249313	0	SSeCKS	0,6	cyclin_D1	18,27	SSeCKS	cyclin D1	83397(Tax:10090)	12443(Tax:10090)	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	SSeCKS sequesters cyclin_D1 in glomerular parietal epithelial cells and influences proliferative_injury in the glomerulus .
19546220	0	ST14	0,4	miR-27b	61,68	ST14	miR-27b	6768	407019	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	ST14 -LRB- suppression_of_tumorigenicity_14 -RRB- gene is a target for miR-27b , and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation .
19546220	0	ST14	99,103	miR-27b	137,144	ST14	miR-27b	6768	407019	Gene	Gene	effect|nmod|START_ENTITY independent|nsubj|effect independent|nmod|regulation regulation|amod|END_ENTITY	ST14 -LRB- suppression_of_tumorigenicity_14 -RRB- gene is a target for miR-27b , and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation .
19546220	0	ST14	0,4	suppression_of_tumorigenicity_14	6,38	ST14	suppression of tumorigenicity 14	6768	6768	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	ST14 -LRB- suppression_of_tumorigenicity_14 -RRB- gene is a target for miR-27b , and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation .
8459652	0	ST1A1	70,75	sulfotransferase	52,68	ST1A1	sulfotransferase	83783(Tax:10116)	83783(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Expression and functional characterization of a rat sulfotransferase -LRB- ST1A1 -RRB- cDNA for sulfations of phenolic substrates in COS-1 cells .
18450470	0	ST2	122,125	IL-33	137,142	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	ability|nmod|START_ENTITY enhances|dobj|ability enhances|xcomp|inhibit inhibit|dobj|END_ENTITY	The IL-1_receptor_accessory_protein -LRB- AcP -RRB- is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33 .
18827826	0	ST2	10,13	IL-33	4,9	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The IL-33 / ST2 pathway : therapeutic target and novel biomarker .
20662097	0	ST2	20,23	IL-33	59,64	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY transgenic_mice|nsubj|Characterization transgenic_mice|nmod|END_ENTITY	Characterization of ST2 transgenic_mice with resistance to IL-33 .
21356240	0	ST2	10,13	IL-33	4,9	ST2	IL-33	6761	90865	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The IL-33 / ST2 pathway -- A new therapeutic target in cardiovascular_disease .
21703183	0	ST2	25,28	IL-33	19,24	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|END_ENTITY	Protective role of IL-33 / ST2 axis in Con A-induced hepatitis .
22233535	0	ST2	35,38	IL-33	12,17	ST2	IL-33	6761	90865	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic_rhinitis .
22349136	0	ST2	20,23	IL-33	6,11	ST2	IL-33	6761	90865	Gene	Gene	level|nummod|START_ENTITY not|nmod:npmod|level elevated|neg|not elevated|nsubj|END_ENTITY	Serum IL-33 but not ST2 level is elevated in intermittent_allergic_rhinitis and is a marker of the disease severity .
22392053	0	ST2	6,9	IL-33	0,5	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|appos|axis	IL-33 / ST2 axis in inflammation and immunopathology .
22454393	0	ST2	76,79	IL-33	0,5	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	improves|nsubj|START_ENTITY induces|parataxis|improves induces|nsubj|END_ENTITY	IL-33 independently induces eosinophilic_pericarditis and cardiac_dilation : ST2 improves cardiac function .
22720252	0	ST2	6,9	IL-33	0,5	ST2	IL-33	6761	90865	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|appos|axis	IL-33 / ST2 axis in innate and acquired immunity to tumors .
23283516	0	ST2	35,38	IL-33	29,34	ST2	IL-33	6761	90865	Gene	Gene	system|nummod|START_ENTITY role|dep|system role|nmod|END_ENTITY	The evolutionary role of the IL-33 / ST2 system in host immune defence .
23300625	0	ST2	17,20	IL-33	11,16	ST2	IL-33	6761	90865	Gene	Gene	activation|nummod|START_ENTITY prolongs|nsubj|activation END_ENTITY|parataxis|prolongs	Disordered IL-33 / ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy_loss .
23347081	0	ST2	6,9	IL-33	0,5	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY contributes|nsubj|signalling END_ENTITY|appos|contributes	IL-33 / ST2 signalling contributes to carrageenin-induced innate inflammation and inflammatory pain : role of cytokines , endothelin-1 and prostaglandin_E2 .
23484079	0	ST2	40,43	IL-33	34,39	ST2	IL-33	6761	90865	Gene	Gene	system|nummod|START_ENTITY modulation|dep|system modulation|nmod|END_ENTITY	Innate immunity modulation by the IL-33 / ST2 system in intestinal mucosa .
23662055	0	ST2	139,142	IL-33	133,138	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	axis|nsubj|START_ENTITY Intravenously|parataxis|axis Intravenously|acl|delivered delivered|ccomp|induce induce|dobj|responses responses|nmod|END_ENTITY	Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33 / ST2 axis .
23733876	0	ST2	10,13	IL-33	4,9	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	The IL-33 / ST2 pathway controls coxsackievirus B5-induced experimental pancreatitis .
24045639	0	ST2	10,13	IL-33	4,9	ST2	IL-33	6761	90865	Gene	Gene	axis|compound|START_ENTITY associated|nsubjpass|axis END_ENTITY|parataxis|associated	The IL-33 / ST2 axis is associated with human visceral_leishmaniasis and suppresses Th1 responses in the livers of BALB/c mice infected with Leishmania_donovani .
24122812	0	ST2	37,40	IL-33	14,19	ST2	IL-33	6761	90865	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of IL-33 and its receptor ST2 in chronic rhinosinusitis with nasal_polyps .
24385685	0	ST2	6,9	IL-33	0,5	ST2	IL-33	6761	90865	Gene	Gene	pathway|nummod|START_ENTITY submitted|nsubj|pathway END_ENTITY|appos|submitted	IL-33 / ST2 pathway and classical cytokines in end-stage heart_failure patients submitted to left ventricular assist device support : a paradoxic role for inflammatory mediators ?
24446582	0	ST2	18,21	IL-33	12,17	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	ameliorates|nummod|START_ENTITY Blockade|dep|ameliorates Blockade|nmod|END_ENTITY	Blockade of IL-33 / ST2 ameliorates airway inflammation in a murine model of allergic_asthma .
24675360	0	ST2	42,45	IL-33	36,41	ST2	IL-33	6761	90865	Gene	Gene	pathway|nummod|START_ENTITY progenitors|nsubj|pathway deregulation|parataxis|progenitors deregulation|nmod|END_ENTITY	BCR-ABL-induced deregulation of the IL-33 / ST2 pathway in CD34 + progenitors from chronic_myeloid_leukemia patients .
24837094	0	ST2	20,23	IL-33	14,19	ST2	IL-33	25556(Tax:10116)	361749(Tax:10116)	Gene	Gene	system|nummod|START_ENTITY Modulation|dep|system Modulation|nmod|END_ENTITY	Modulation of IL-33 / ST2 system in postinfarction heart_failure : correlation with cardiac remodelling markers .
25003325	0	ST2	32,35	IL-33	8,13	ST2	IL-33	6761	90865	Gene	Gene	receptor|compound|START_ENTITY regulates|dobj|receptor regulates|nsubj|END_ENTITY	Nuclear IL-33 regulates soluble ST2 receptor and IL-6 expression in primary human arterial endothelial cells and is decreased in idiopathic_pulmonary_arterial_hypertension .
25200162	0	ST2	7,10	IL-33	1,6	ST2	IL-33	6761	90865	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	-LSB- IL-33 / ST2 promotes airway remodeling in asthma by activating the expression of fibronectin_1 and type 1 collagen in human lung fibroblasts -RSB- .
25280997	0	ST2	6,9	IL-33	0,5	ST2	IL-33	6761	90865	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|appos|contributes	IL-33 / ST2 pathway contributes to metastasis of human colorectal_cancer .
25324197	0	ST2	22,25	IL-33	16,21	ST2	IL-33	6761	90865	Gene	Gene	network|nummod|START_ENTITY Dynamics|dep|network Dynamics|nmod|END_ENTITY	Dynamics of the IL-33 / ST2 network in the progression of human colorectal_adenoma_to_sporadic_colorectal_cancer .
25457999	0	ST2	41,44	IL-33	71,76	ST2	IL-33	6761	90865	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|advcl|inhibiting inhibiting|dobj|action action|nmod|END_ENTITY	Vitamin_D enhances production of soluble ST2 , inhibiting the action of IL-33 .
25517029	0	ST2	39,42	IL-33	33,38	ST2	IL-33	6761	90865	Gene	Gene	Genes|compound|START_ENTITY Associations|dep|Genes Associations|nmod|END_ENTITY	Associations between Variants in IL-33 / ST2 Signaling Pathway Genes and Coronary_Heart_Disease Risk .
25658420	0	ST2	6,9	IL-33	0,5	ST2	IL-33	6761	90865	Gene	Gene	correlates|nsubj|START_ENTITY END_ENTITY|appos|correlates	IL-33 / ST2 correlates with severity of haemorrhagic_fever_with_renal_syndrome and regulates the inflammatory response in Hantaan_virus-infected endothelial cells .
25682948	0	ST2	32,35	IL-33	17,22	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|receptor receptor|compound|END_ENTITY	Critical role of IL-33 receptor ST2 in experimental_cerebral_malaria development .
25693767	0	ST2	6,9	IL-33	0,5	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	involves|nsubj|START_ENTITY END_ENTITY|appos|involves	IL-33 / ST2 involves the immunopathology of ocular_toxoplasmosis in murine model .
25721734	0	ST2	16,19	IL-33	0,5	ST2	IL-33	6761	77125(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	IL-33 receptor -LRB- ST2 -RRB- signaling is important for regulation of Th2-mediated airway inflammation in a murine model of acute_respiratory_syncytial_virus_infection .
25747940	0	ST2	6,9	IL-33	0,5	ST2	IL-33	6761	90865	Gene	Gene	axis|compound|START_ENTITY controls|nsubj|axis END_ENTITY|appos|controls	IL-33 / ST2 axis controls Th2/IL -31 and Th17 immune response in allergic airway_diseases .
25798875	0	ST2	18,21	IL-33	0,5	ST2	IL-33	6761	90865	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	IL-33 and soluble ST2 levels as novel predictors for remission_and_progression_of_carotid_plaque in early rheumatoid_arthritis : A prospective study .
25881899	0	ST2	28,31	IL-33	22,27	ST2	IL-33	6761	90865	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	The potential role of IL-33 / ST2 signaling in fibrotic_diseases .
26277897	0	ST2	10,13	IL-33	4,9	ST2	IL-33	6761	90865	Gene	Gene	axis|compound|START_ENTITY required|nsubjpass|axis END_ENTITY|parataxis|required	The IL-33 / ST2 axis is specifically required for development of adipose tissue-resident regulatory T cells .
26343805	0	ST2	28,31	IL-33	22,27	ST2	IL-33	6761	90865	Gene	Gene	axis|nummod|START_ENTITY role|dep|axis role|nmod|END_ENTITY	Potential role of the IL-33 / ST2 axis in celiac_disease .
26352378	0	ST2	13,16	IL-33	7,12	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	Contributes|compound|START_ENTITY END_ENTITY|dep|Contributes	Spinal IL-33 / ST2 Signaling Contributes to Neuropathic_Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice .
26417439	0	ST2	66,69	IL-33	60,65	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Atherosclerosis severity is not affected by a deficiency in IL-33 / ST2 signaling .
26555705	0	ST2	20,23	IL-33	4,9	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The IL-33 receptor -LRB- ST2 -RRB- regulates early IL-13 production in fungus-induced allergic_airway_inflammation .
26598236	0	ST2	33,36	IL-33	27,32	ST2	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	Link|compound|START_ENTITY Effects|dep|Link Effects|nmod|END_ENTITY	Osteoprotective Effects of IL-33 / ST2 Link to Osteoclast Apoptosis .
26942077	0	ST2	10,13	IL-33	4,9	ST2	IL-33	6761	90865	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|parataxis|contributes	The IL-33 / ST2 pathway contributes to intestinal tumorigenesis in humans and mice .
26944417	0	ST2	40,43	IL-33	34,39	ST2	IL-33	17082(Tax:10090)	90865	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Expression and potential roles of IL-33 / ST2 in the immune regulation during Clonorchis_sinensis_infection .
27031441	0	ST2	18,21	IL-33	44,49	ST2	IL-33	6761	90865	Gene	Gene	specific|compound|START_ENTITY Reconstitution|nmod|specific Reconstitution|nmod|activity activity|compound|END_ENTITY	Reconstitution of ST2 -LRB- IL-1R4 -RRB- specific for IL-33 activity ; no suppression by IL-1Ra though a common chain IL-1R3 -LRB- IL-1RAcP -RRB- shared with IL-1 .
24105680	0	ST2	15,18	Interleukin-33	0,14	ST2	Interleukin-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY promotes|nsubj|axis END_ENTITY|parataxis|promotes	Interleukin-33 / ST2 axis promotes breast_cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells .
24866242	0	ST2	15,18	Interleukin-33	0,14	ST2	Interleukin-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY promotes|nsubj|signaling END_ENTITY|parataxis|promotes	Interleukin-33 / ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic_obstructive_pulmonary_disease mice .
25712928	0	ST2	47,50	Interleukin-33	32,46	ST2	Interleukin-33	6761	90865	Gene	Gene	Axis|compound|START_ENTITY Role|dep|Axis Role|nmod|END_ENTITY	Crucial and Diverse Role of the Interleukin-33 / ST2 Axis in Infectious_Diseases .
25896545	0	ST2	15,18	Interleukin-33	0,14	ST2	Interleukin-33	6761	90865	Gene	Gene	system|compound|START_ENTITY attenuates|nsubj|system END_ENTITY|parataxis|attenuates	Interleukin-33 / ST2 system attenuates aldosterone-induced adipogenesis and inflammation .
11478810	0	ST2	80,83	ST2V	98,102	ST2	ST2V	6761	9173	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Tissue distribution and subcellular localization of a variant form of the human ST2 gene product , ST2V .
20400705	0	ST2	0,3	TLR2	25,29	ST2	TLR2	17082(Tax:10090)	24088(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	ST2 negatively regulates TLR2 signaling , but is not required for bacterial lipoprotein-induced tolerance .
22361513	0	ST2	0,3	Th2	13,16	ST2	Th2	17082(Tax:10090)	15111(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	ST2 requires Th2 - , but not Th17 - , type airway_inflammation in epicutaneously antigen - sensitized mice .
12445813	0	ST2	119,122	bone_morphogenetic_protein-4	29,57	ST2	bone morphogenetic protein-4	17082(Tax:10090)	12159(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Phosphate depletion enhances bone_morphogenetic_protein-4 gene expression in a cultured mouse marrow stromal cell line ST2 .
23483993	0	ST2	66,69	interleukin-1_receptor_like_1	35,64	ST2	interleukin-1 receptor like 1	17082(Tax:10090)	17082(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Limited anti-inflammatory role for interleukin-1_receptor_like_1 -LRB- ST2 -RRB- in the host response to murine postinfluenza pneumococcal_pneumonia .
17623648	0	ST2	8,11	interleukin-33	19,33	ST2	interleukin-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	blocks|nsubj|START_ENTITY blocks|xcomp|END_ENTITY	Soluble ST2 blocks interleukin-33 signaling in allergic_airway_inflammation .
23172891	0	ST2	37,40	interleukin-33	22,36	ST2	interleukin-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Neutralisation of the interleukin-33 / ST2 pathway ameliorates experimental colitis through enhancement of mucosal_healing in mice .
23567618	0	ST2	33,36	interleukin-33	18,32	ST2	interleukin-33	6761	90865	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Components of the interleukin-33 / ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature .
23903682	0	ST2	18,21	interleukin-33	3,17	ST2	interleukin-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	An interleukin-33 / ST2 signaling deficiency reduces overt_pain-like_behaviors in mice .
24940745	0	ST2	120,123	interleukin-33	32,46	ST2	interleukin-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	blocking|dobj|START_ENTITY characteristics|acl|blocking presenting|parataxis|characteristics presenting|dobj|molecules molecules|amod|END_ENTITY	Virus-like particles presenting interleukin-33 molecules : Immunization characteristics and potentials of blocking IL-33 / ST2 pathway in allergic_airway_inflammation .
20638676	0	ST2	44,47	interleukin_33	17,31	ST2	interleukin 33	6761	90865	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Up-regulation of interleukin_33 and soluble ST2 serum levels in liver_failure .
23585867	0	ST2	23,26	interleukin_33	8,22	ST2	interleukin 33	6761	90865	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|parataxis|regulates	A novel interleukin_33 / ST2 signaling regulates inflammatory response in human corneal epithelium .
26312920	0	ST2	23,26	interleukin_33	8,22	ST2	interleukin 33	6761	90865	Gene	Gene	axis|nummod|START_ENTITY Role|dep|axis Role|nmod|END_ENTITY	Role of interleukin_33 / ST2 axis in the immune-mediated pathogenesis of age-related macular_degeneration .
20959556	0	ST2	41,44	suppression_of_tumorigenicity_2	8,39	ST2	suppression of tumorigenicity 2	17082(Tax:10090)	17082(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Loss of suppression_of_tumorigenicity_2 -LRB- ST2 -RRB- gene reverses sepsis-induced inhibition of lung host defense in mice .
21949025	0	ST2L	77,81	Foxp3	83,88	ST2L	Foxp3	17082(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ cells|amod|END_ENTITY	IL-33 expands suppressive CD11b + Gr-1 -LRB- int -RRB- and regulatory T cells , including ST2L + Foxp3 + cells , and mediates regulatory T cell-dependent promotion of cardiac allograft survival .
20406635	0	ST2L	62,66	IL-33	56,61	ST2L	IL-33	9173	90865	Gene	Gene	axis|nummod|START_ENTITY model|dep|axis model|nmod|END_ENTITY	KU812 cells provide a novel in vitro model of the human IL-33 / ST2L axis : functional responses and identification of signaling pathways .
21949025	0	ST2L	77,81	IL-33	0,5	ST2L	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	+|compound|START_ENTITY cells|nummod|+ expands|nmod|cells expands|dep|END_ENTITY	IL-33 expands suppressive CD11b + Gr-1 -LRB- int -RRB- and regulatory T cells , including ST2L + Foxp3 + cells , and mediates regulatory T cell-dependent promotion of cardiac allograft survival .
25662624	0	ST2L	18,22	IL-33	12,17	ST2L	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	signals|nummod|START_ENTITY role|dep|signals role|nmod|END_ENTITY	The role of IL-33 / ST2L signals in the immune cells .
26679377	0	ST2L	48,52	IL-33	32,37	ST2L	IL-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	An antitumorigenic role for the IL-33 receptor , ST2L , in colon_cancer .
19996325	0	ST2L	83,87	interleukin_33	42,56	ST2L	interleukin 33	9173	90865	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of interleukin 1-like cytokine interleukin_33 and its receptor complex -LRB- ST2L and IL1RAcP -RRB- in human pancreatic myofibroblasts .
11478810	0	ST2V	98,102	ST2	80,83	ST2V	ST2	9173	6761	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Tissue distribution and subcellular localization of a variant form of the human ST2 gene product , ST2V .
9632734	0	ST5	86,89	extracellular_signal-regulated_kinase_2	14,53	ST5	extracellular signal-regulated kinase 2	6764	5594	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Activation of extracellular_signal-regulated_kinase_2 by a novel Abl-binding protein , ST5 .
12213789	0	ST6Gal_I	43,51	CD22	24,28	ST6Gal I	CD22	20440(Tax:10090)	12483(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY cells|nmod|mice END_ENTITY|nmod|cells	Constitutively unmasked CD22 on B cells of ST6Gal_I knockout mice : novel sialoside probe for murine CD22 .
12063568	0	ST7-like	20,28	ST7R	14,18	ST7-like	ST7R	54879	54879	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ST7R -LRB- ST7-like , ST7L -RRB- in normal tissues and cancer .
12063568	0	ST7R	14,18	ST7-like	20,28	ST7R	ST7-like	54879	54879	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ST7R -LRB- ST7-like , ST7L -RRB- in normal tissues and cancer .
11098147	0	ST8Sia_I	84,92	GD3_synthase	65,77	ST8Sia I	GD3 synthase	20449(Tax:10090)	20449(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and transcriptional regulation of the mouse GD3_synthase gene -LRB- ST8Sia_I -RRB- : comparison of genomic organization of the mouse sialyltransferase genes .
8702635	0	ST8Sia_II	26,35	STX	37,40	ST8Sia II	STX	20450(Tax:10090)	20450(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of mouse ST8Sia_II -LRB- STX -RRB- as a neural_cell_adhesion_molecule-specific polysialic_acid synthase .
14667815	0	STAF	47,51	aldehyde_reductase	14,32	STAF	aldehyde reductase	7702	10327	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of aldehyde_reductase expression by STAF and CHOP .
26601948	0	STAM	55,59	Signal-transducing_Adaptor_Molecule	18,53	STAM	Signal-transducing Adaptor Molecule	8027	8027	Gene	Gene	Domain|appos|START_ENTITY Domain|nmod|END_ENTITY	The VHS Domain of Signal-transducing_Adaptor_Molecule -LRB- STAM -RRB- Directs Associated Molecule with the SH3 Domain of STAM -LRB- AMSH -RRB- Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage .
21205088	0	STAP-2	15,21	STAT5	72,77	STAP-2	STAT5	55620	6776	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast_cancer cells .
18755854	0	STAR	52,56	JUN	12,15	STAR	JUN	20845(Tax:10090)	16476(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression role|nmod|regulation role|nmod|END_ENTITY	The role of JUN in the regulation of PRKCC-mediated STAR expression and steroidogenesis in mouse Leydig cells .
19179481	0	STAR	81,85	steroidogenic_acute_regulatory	49,79	STAR	steroidogenic acute regulatory	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	cAMP-dependent posttranscriptional regulation of steroidogenic_acute_regulatory -LRB- STAR -RRB- protein by the zinc finger protein ZFP36L1/TIS11b .
16155961	0	STAR	67,71	steroidogenic_acute_regulatory_protein	27,65	STAR	steroidogenic acute regulatory protein	396597(Tax:9823)	396597(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression analysis of the steroidogenic_acute_regulatory_protein -LRB- STAR -RRB- gene in developing porcine conceptuses .
22575868	0	STARD1	91,97	steroidogenic_acute_regulatory_protein	51,89	STARD1	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	Identification|appos|START_ENTITY Identification|nmod|inhibitors inhibitors|nmod|END_ENTITY	Identification of small-molecule inhibitors of the steroidogenic_acute_regulatory_protein -LRB- STARD1 -RRB- by structure-based design .
21777804	0	STARs	12,17	TNF-a	21,26	STARs	TNF-a	137735	7124	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Sam68 guest STARs in TNF-a signaling .
23583584	0	STAT	19,23	Socs36E	0,7	STAT	Socs36E	42428(Tax:7227)	35085(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|attenuates attenuates|amod|END_ENTITY	Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary .
26277564	0	STAT	15,19	Socs36E	0,7	STAT	Socs36E	42428(Tax:7227)	35085(Tax:7227)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Socs36E Limits STAT Signaling via Cullin2 and a SOCS-Box Independent Mechanism in the Drosophila Egg Chamber .
11846485	0	STAT	15,19	stat92E	29,36	STAT	stat92E	42428(Tax:7227)	42428(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Drosophila STAT protein , stat92E , regulates follicle cell differentiation during oogenesis .
11737062	0	STAT-1	64,70	Cytokine_receptor	0,17	STAT-1	Cytokine receptor	6772	8809	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|dep|phosphorylation	Cytokine_receptor signalling in neonatal macrophages : defective STAT-1 phosphorylation in response to stimulation with IFN-gamma .
18634870	0	STAT-1	15,21	HO-1	0,4	STAT-1	HO-1	20846(Tax:10090)	15368(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY signals|amod|END_ENTITY	HO-1 and JAK-2 / STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline_alkaloid , CKD712 , in cells activated with lipopolysacchride .
24878287	0	STAT-1	0,6	IGFBP-3	34,41	STAT-1	IGFBP-3	6772	3486	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	STAT-1 expression is regulated by IGFBP-3 in malignant_glioma cells and is a strong predictor of poor survival in patients with glioblastoma .
15261459	0	STAT-1	0,6	IL-4	23,27	STAT-1	IL-4	6772	3565	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	STAT-1 is activated by IL-4 and IL-13 in multiple cell types .
16555329	0	STAT-1	108,114	IRF-1	115,120	STAT-1	IRF-1	25124(Tax:10116)	24508(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1 / IRF-1 pathway during tolerance induction .
14602726	0	STAT-1	0,6	p53	22,25	STAT-1	p53	6772	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis .
16540526	0	STAT-3	62,68	CD25	92,96	STAT-3	CD25	6774	3559	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4 + CD25 - and CD25high regulatory T cells .
17241887	0	STAT-3	15,21	IL-6	10,14	STAT-3	IL-6	6774	3569	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Sustained IL-6 / STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing .
18333366	0	STAT-3	7,13	IL-6	0,4	STAT-3	IL-6	6774	3569	Gene	Gene	linking|nsubj|START_ENTITY END_ENTITY|appos|linking	IL-6 - STAT-3 - hepcidin : linking inflammation to the iron metabolism .
18473764	0	STAT-3	53,59	IL-6	48,52	STAT-3	IL-6	6774	3569	Gene	Gene	trans|compound|START_ENTITY signaling|nsubj|trans molecules|parataxis|signaling molecules|dep|role role|nmod|END_ENTITY	Signaling molecules : the pathogenic role of the IL-6 / STAT-3 trans signaling pathway in intestinal inflammation and in colonic_cancer .
24390735	0	STAT-3	31,37	IL-6	26,30	STAT-3	IL-6	6774	3569	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	HAVCR/KIM -1 activates the IL-6 / STAT-3 pathway in clear_cell_renal_cell_carcinoma and determines tumor progression and patient outcome .
25830055	0	STAT-3	30,36	IL-6	25,29	STAT-3	IL-6	6774	3569	Gene	Gene	Signals|compound|START_ENTITY Signals|compound|END_ENTITY	Quercetin Down-regulates IL-6 / STAT-3 Signals to Induce Mitochondrial-mediated Apoptosis in a Nonsmall - cell Lung-cancer Cell Line , A549 .
9923604	0	STAT-3	36,42	Interleukin-1beta	0,17	STAT-3	Interleukin-1beta	6774	3553	Gene	Gene	isoform|compound|START_ENTITY activates|dobj|isoform activates|nsubj|END_ENTITY	Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells .
11705792	0	STAT-3	27,33	SOCS-3	56,62	STAT-3	SOCS-3	25125(Tax:10116)	89829(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Constitutive activation of STAT-3 and downregulation of SOCS-3 expression induced by adrenalectomy .
15650183	0	STAT-3	49,55	STAT-3	86,92	STAT-3	STAT-3	6774	6774	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Hepatitis_C_virus _ -LRB- HCV -RRB- constitutively activates STAT-3 via oxidative stress : role of STAT-3 in HCV replication .
15650183	0	STAT-3	86,92	STAT-3	49,55	STAT-3	STAT-3	6774	6774	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Hepatitis_C_virus _ -LRB- HCV -RRB- constitutively activates STAT-3 via oxidative stress : role of STAT-3 in HCV replication .
18408167	0	STAT-3	36,42	VEGF	64,68	STAT-3	VEGF	6774	7422	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis .
25869100	0	STAT-3	133,139	b-catenin	14,23	STAT-3	b-catenin	6774	1499	Gene	Gene	role|nmod|START_ENTITY Inhibition|dep|role Inhibition|nmod|END_ENTITY	Inhibition of b-catenin signaling suppresses pancreatic_tumor growth by disrupting nuclear b-catenin/TCF -1 complex : critical role of STAT-3 .
9461509	0	STAT-3	98,104	signal_transducer_and_activator_of_transcription-3	46,96	STAT-3	signal transducer and activator of transcription-3	6774	6774	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	The nuclear factor interleukin-6 -LRB- NF-IL6 -RRB- and signal_transducer_and_activator_of_transcription-3 -LRB- STAT-3 -RRB- signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat_shock .
17090651	0	STAT-5	157,163	JAK-2	151,156	STAT-5	JAK-2	6776	3717	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Adaptive secretion of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- mediates imatinib and nilotinib resistance in BCR/ABL + progenitors via JAK-2 / STAT-5 pathway activation .
11086058	0	STAT-6	15,21	CD40	49,53	STAT-6	CD40	6778	958	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	IL-4-activated STAT-6 inhibits IFN-gamma-induced CD40 gene expression in macrophages/microglia .
16142755	0	STAT-6	65,71	JNK	92,95	STAT-6	JNK	20852(Tax:10090)	26419(Tax:10090)	Gene	Gene	START_ENTITY|nmod|blockade blockade|nmod|END_ENTITY	Inhibition of inflammatory bone_erosion by constitutively active STAT-6 through blockade of JNK and NF-kappaB activation .
17617590	0	STAT-6	101,107	TNF-alpha	35,44	STAT-6	TNF-alpha	6778	7124	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	IL-4 and IL-13 negatively regulate TNF-alpha - and IFN-gamma-induced beta-defensin expression through STAT-6 , suppressor_of_cytokine_signaling _ -LRB- SOCS -RRB- -1 , and SOCS-3 .
26915678	0	STAT-6	105,111	signal_transducer_and_activator_of_transcription_6	53,103	STAT-6	signal transducer and activator of transcription 6	6778	6778	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Nonsteroidal anti-inflammatory-induced inhibition of signal_transducer_and_activator_of_transcription_6 -LRB- STAT-6 -RRB- phosphorylation in aspirin-exacerbated respiratory_disease .
20457620	0	STAT1	73,78	BCL2	116,120	STAT1	BCL2	6772	596	Gene	Gene	members|nummod|START_ENTITY members|amod|END_ENTITY	IFNgamma restores_breast_cancer sensitivity to fulvestrant by regulating STAT1 , IFN_regulatory_factor_1 , NF-kappaB , BCL2 family members , and signaling to caspase-dependent apoptosis .
17346710	0	STAT1	0,5	Bax	29,32	STAT1	Bax	6772	581	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	STAT1 regulates p73-mediated Bax gene expression .
17548649	0	STAT1	0,5	Bax	41,44	STAT1	Bax	20846(Tax:10090)	12028(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY causes|nsubj|activation causes|dobj|translocation translocation|nmod|END_ENTITY	STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous_cell_hyperplasia by IFN-gamma .
24489092	0	STAT1	30,35	Bcl6	39,43	STAT1	Bcl6	6772	604	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Type I IFN induces binding of STAT1 to Bcl6 : divergent roles of STAT family transcription factors in the T follicular helper cell genetic program .
14699080	0	STAT1	72,77	CD25	29,33	STAT1	CD25	20846(Tax:10090)	16184(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY cells|nmod|absence cells|dep|development development|nmod|+ +|compound|END_ENTITY	Impaired development of CD4 + CD25 + regulatory T cells in the absence of STAT1 : increased susceptibility to autoimmune_disease .
14699080	0	STAT1	72,77	CD4	24,27	STAT1	CD4	20846(Tax:10090)	12504(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY cells|nmod|absence cells|dep|development development|nmod|+ +|compound|END_ENTITY	Impaired development of CD4 + CD25 + regulatory T cells in the absence of STAT1 : increased susceptibility to autoimmune_disease .
21115047	0	STAT1	109,114	CD4	69,72	STAT1	CD4	6772	920	Gene	Gene	phosphorylation|nmod|START_ENTITY cells|nmod|phosphorylation cells|compound|END_ENTITY	IL-27 induces the differentiation of Tr1-like cells from human naive CD4 + T cells via the phosphorylation of STAT1 and STAT3 .
22496215	0	STAT1	18,23	CD4	63,66	STAT1	CD4	6772	920	Gene	Gene	deficient|nmod|START_ENTITY develop|nsubj|deficient develop|dobj|disease disease|compound|END_ENTITY	Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4 + T-cell-mediated disease following infection with lymphocytic_choriomeningitis_virus .
25261409	0	STAT1	111,116	CD4	55,58	STAT1	CD4	6772	920	Gene	Gene	activation|nmod|START_ENTITY apoptosis|nmod|activation sensitizes|nmod|apoptosis sensitizes|dobj|cells cells|compound|END_ENTITY	Epigallocatechin-3-gallate sensitizes IFN-y-stimulated CD4 + T cells to apoptosis via alternative activation of STAT1 .
26170288	0	STAT1	18,23	CD4	55,58	STAT1	CD4	6772	920	Gene	Gene	roles|nmod|START_ENTITY function|nsubj|roles function|nmod|cells cells|compound|END_ENTITY	Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 + T cells .
16210337	0	STAT1	14,19	CD8	56,59	STAT1	CD8	6772	925	Gene	Gene	levels|compound|START_ENTITY Modulation|nmod|levels Modulation|dep|mechanism mechanism|acl|shaping shaping|dobj|responses responses|compound|END_ENTITY	Modulation of STAT1 protein levels : a mechanism shaping CD8 T-cell responses in vivo .
18250422	0	STAT1	0,5	CD8	19,22	STAT1	CD8	6772	925	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	STAT1 signaling in CD8 T cells is required for their clonal expansion and memory_formation_following_viral_infection in vivo .
12403783	0	STAT1	69,74	CREB-binding_protein	32,52	STAT1	CREB-binding protein	6772	1387	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The transcriptional coactivator CREB-binding_protein cooperates with STAT1 and NF-kappa_B for synergistic transcriptional activation of the CXC_ligand_9 / monokine_induced_by_interferon-gamma gene .
9000134	0	STAT1	77,82	CSF-1_receptor	58,72	STAT1	CSF-1 receptor	6772	1436	Gene	Gene	activation|nummod|START_ENTITY END_ENTITY|nmod|activation	Requirement for Y706 of the murine -LRB- or Y708 of the human -RRB- CSF-1_receptor for STAT1 activation in response to CSF-1 .
21084836	0	STAT1	0,5	Cdk4	40,44	STAT1	Cdk4	6772	1019	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	STAT1 interacts directly with cyclin_D1 / Cdk4 and mediates cell cycle arrest .
11713584	0	STAT1	44,49	EGFR	0,4	STAT1	EGFR	6772	1956	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	EGFR dependent expression of STAT3 -LRB- but not STAT1 -RRB- in breast_cancer .
17918184	0	STAT1	37,42	EGFR	0,4	STAT1	EGFR	6772	1956	Gene	Gene	activation|compound|START_ENTITY IRF-1|nmod|activation expression|nmod|IRF-1 induces|dobj|expression induces|nsubj|END_ENTITY	EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells .
22693070	0	STAT1	0,5	EGFR	45,49	STAT1	EGFR	6772	1956	Gene	Gene	expression|nummod|START_ENTITY enhanced|nsubjpass|expression enhanced|nmod|END_ENTITY	STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 .
26141950	0	STAT1	0,5	EGFR	67,71	STAT1	EGFR	6772	1956	Gene	Gene	Activation|compound|START_ENTITY Enhanced|nsubjpass|Activation Enhanced|nmod|Inhibition Inhibition|compound|END_ENTITY	STAT1 Activation Is Enhanced by Cisplatin and Variably Affected by EGFR Inhibition in HNSCC Cells .
26795953	0	STAT1	58,63	ERK1/2	41,47	STAT1	ERK1/2	6772	5595;5594	Gene	Gene	activation|compound|START_ENTITY activation|nummod|END_ENTITY	PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts .
23644631	0	STAT1	50,55	IFN-a	10,15	STAT1	IFN-a	20846(Tax:10090)	111654(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of IFN-a on KC and LIX expression : role of STAT1 and its effect on neutrophil recruitment to the spleen after lipopolysaccharide stimulation .
17878351	0	STAT1	39,44	IFN-epsilon	0,11	STAT1	IFN-epsilon	6772	338376	Gene	Gene	phosphorylation|compound|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	IFN-epsilon mediates TNF-alpha-induced STAT1 phosphorylation and induction of retinoic_acid-inducible gene-I in human cervical_cancer cells .
17634555	0	STAT1	99,104	IFN_gamma	63,72	STAT1	IFN gamma	20846(Tax:10090)	15978(Tax:10090)	Gene	Gene	effect|nummod|START_ENTITY enhancing|dobj|effect tumors|acl|enhancing directs|nmod|tumors directs|dobj|accumulation accumulation|nmod|END_ENTITY	Doxorubicin directs the accumulation of interleukin-12 induced IFN_gamma into tumors for enhancing STAT1 dependent antitumor effect .
26217191	0	STAT1	66,71	IFN_gamma	0,9	STAT1	IFN gamma	25124(Tax:10116)	25712(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	IFN_gamma regulates proliferation and neuronal differentiation by STAT1 in adult SVZ niche .
15778351	0	STAT1	40,45	IFN_regulatory_factor-2	0,23	STAT1	IFN regulatory factor-2	6772	3660	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	IFN_regulatory_factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity .
12967644	0	STAT1	48,53	IFNalpha	0,8	STAT1	IFNalpha	6772	3439	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	IFNalpha regulates NK cell cytotoxicity through STAT1 pathway .
26170288	0	STAT1	18,23	IL-21	37,42	STAT1	IL-21	6772	59067	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of STAT1 and STAT3 in IL-21 function in CD4 + T cells .
23153456	0	STAT1	59,64	IL-22	14,19	STAT1	IL-22	6772	50616	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|advcl|activating	IFNa converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets .
19587017	0	STAT1	0,5	IL-4	41,45	STAT1	IL-4	20846(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory_syncytial_virus_infection .
17918184	0	STAT1	37,42	IRF-1	27,32	STAT1	IRF-1	6772	3659	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	EGFR induces expression of IRF-1 via STAT1 and STAT3 activation leading to growth arrest of human cancer cells .
10102295	0	STAT1	81,86	Interferon-gamma	0,16	STAT1	Interferon-gamma	6772	3458	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|dep|mediated	Interferon-gamma signaling in human_retinal_pigment_epithelial cells mediated by STAT1 , ICSBP , and IRF-1 transcription factors .
12868960	0	STAT1	139,144	Interferon-gamma	0,16	STAT1	Interferon-gamma	20846(Tax:10090)	15978(Tax:10090)	Gene	Gene	signal_transduction_and_activator_of_transduction_factor_1|appos|START_ENTITY macrophages|nmod|signal_transduction_and_activator_of_transduction_factor_1 systems|nmod|macrophages regulates|dobj|systems regulates|nsubj|END_ENTITY	Interferon-gamma regulates nucleoside transport systems in macrophages through signal_transduction_and_activator_of_transduction_factor_1 -LRB- STAT1 -RRB- - dependent and - independent signalling pathways .
15795279	0	STAT1	36,41	Latent_membrane_protein_1	0,25	STAT1	Latent membrane protein 1	6772	9260	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Latent_membrane_protein_1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr_virus-immortalized B cells .
24858600	0	STAT1	0,5	MD-2	16,20	STAT1	MD-2	6772	23643	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a .
11675348	0	STAT1	20,25	Nef	6,9	STAT1	Nef	6772	6285	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors .
10448095	0	STAT1	40,45	PPARgamma	0,9	STAT1	PPARgamma	6772	5468	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	PPARgamma ligand-dependent induction of STAT1 , STAT5A , and STAT5B during adipogenesis .
26795953	0	STAT1	58,63	PRMT1	16,21	STAT1	PRMT1	6772	3276	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|dobj|expression expression|compound|END_ENTITY	PDGF-BB induces PRMT1 expression through ERK1/2 dependent STAT1 activation and regulates remodeling in primary human lung fibroblasts .
22808166	0	STAT1	0,5	RXRa	21,25	STAT1	RXRa	6772	6256	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	STAT1 interacts with RXRa to upregulate ApoCII gene expression in macrophages .
18774104	0	STAT1	62,67	Rac1	39,43	STAT1	Rac1	396655(Tax:9823)	100627149	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial_fibrillation .
14690454	0	STAT1	104,109	STAT1	143,148	STAT1	STAT1	6772	6772	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Interferon-gamma inhibits interferon-alpha signalling in hepatic cells : evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic_hepatitis_C .
14690454	0	STAT1	143,148	STAT1	104,109	STAT1	STAT1	6772	6772	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Interferon-gamma inhibits interferon-alpha signalling in hepatic cells : evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic_hepatitis_C .
11713584	0	STAT1	44,49	STAT3	29,34	STAT1	STAT3	6772	6774	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	EGFR dependent expression of STAT3 -LRB- but not STAT1 -RRB- in breast_cancer .
18620071	0	STAT1	19,24	STAT3	25,30	STAT1	STAT3	6772	6774	Gene	Gene	START_ENTITY|dep|seesaw seesaw|compound|END_ENTITY	Ups and downs : the STAT1 : STAT3 seesaw of Interferon and gp130 receptor signalling .
19424608	0	STAT1	11,16	STAT3	59,64	STAT1	STAT3	6772	6774	Gene	Gene	Absence|nmod|START_ENTITY disturbs|nsubj|Absence disturbs|dobj|effect effect|acl|induced induced|nmod|inhibition inhibition|nummod|END_ENTITY	Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head_and_neck_carcinoma cell lines .
21723864	0	STAT1	46,51	STAT3	94,99	STAT1	STAT3	6772	6774	Gene	Gene	targets|nummod|START_ENTITY targets|nmod|absence absence|nmod|END_ENTITY	The immediate early genes Fos and Egr1 become STAT1 transcriptional targets in the absence of STAT3 .
22110204	0	STAT1	100,105	STAT3	19,24	STAT1	STAT3	6772	6774	Gene	Gene	phosphorylation|nmod|START_ENTITY occurs|nsubj|phosphorylation requires|advcl|occurs requires|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of STAT3 in head_and_neck_cancer requires p38_MAPKinase , whereas phosphorylation of STAT1 occurs via a different signaling pathway .
22693070	0	STAT1	0,5	STAT3	80,85	STAT1	STAT3	6772	6774	Gene	Gene	expression|nummod|START_ENTITY enhanced|nsubjpass|expression enhanced|nmod|END_ENTITY	STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 .
25079358	0	STAT1	11,16	STAT3	84,89	STAT1	STAT3	20846(Tax:10090)	20848(Tax:10090)	Gene	Gene	Absence|nmod|START_ENTITY results|amod|Absence results|nmod|END_ENTITY	Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD .
25364701	0	STAT1	66,71	STAT3	0,5	STAT1	STAT3	6772	6774	Gene	Gene	Apoptosis|nmod|START_ENTITY Apoptosis|compound|END_ENTITY	STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2 .
26255980	0	STAT1	17,22	STAT3	40,45	STAT1	STAT3	6772	6774	Gene	Gene	mutations|compound|START_ENTITY impair|nsubj|mutations impair|dobj|activity activity|compound|END_ENTITY	Gain-of-function STAT1 mutations impair STAT3 activity in patients with Chronic_Mucocutaneous_Candidiasis -LRB- CMC -RRB- .
26299368	0	STAT1	0,5	STAT3	110,115	STAT1	STAT3	6772	6774	Gene	Gene	redirects|compound|START_ENTITY IFN|nsubj|redirects IFN|xcomp|signalling signalling|nmod|activation activation|nmod|END_ENTITY	STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3 .
26673664	0	STAT1	8,13	STAT3	73,78	STAT1	STAT3	20846(Tax:10090)	20848(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY protects|nsubj|Loss protects|nmod|modulation modulation|nmod|Akt Akt|compound|END_ENTITY	Loss of STAT1 protects hair cells from ototoxicity through modulation of STAT3 , c-Jun , Akt , and autophagy factors .
20407011	0	STAT1	0,5	Skp2	16,20	STAT1	Skp2	6772	6502	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells .
24811173	0	STAT1	173,178	Smad3	61,66	STAT1	Smad3	6772	4088	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Caerulomycin_A enhances transforming_growth_factor-b -LRB- TGF-b -RRB- - Smad3 protein signaling by suppressing interferon-y -LRB- IFN-y -RRB- - signal transducer and activator of transcription 1 -LRB- STAT1 -RRB- protein signaling to expand regulatory T cells -LRB- Tregs -RRB- .
20600850	0	STAT1	17,22	activating_transcription_factor_3	31,64	STAT1	activating transcription factor 3	20846(Tax:10090)	11910(Tax:10090)	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	The induction of STAT1 gene by activating_transcription_factor_3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice .
21372127	0	STAT1	73,78	apolipoprotein_E	37,53	STAT1	apolipoprotein E	6772	348	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Macrophage-specific up-regulation of apolipoprotein_E gene expression by STAT1 is achieved via long range genomic interactions .
24086752	0	STAT1	0,5	glutaminase_1	22,35	STAT1	glutaminase 1	6772	2744	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	STAT1 regulates human glutaminase_1 promoter activity through multiple binding sites in HIV-1 infected macrophages .
11161462	0	STAT1	0,5	iNOS	22,26	STAT1	iNOS	20846(Tax:10090)	18126(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	STAT1 is required for iNOS activation , but not IL-6 production in murine fibroblasts .
10506184	0	STAT1	10,15	interferon-gamma	46,62	STAT1	interferon-gamma	25124(Tax:10116)	25712(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY associated|nsubjpass|activation associated|nmod|priming priming|amod|END_ENTITY	Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1-induced inducible_nitric-oxide_synthase expression by islets of Langerhans .
11159690	0	STAT1	92,97	interferon-gamma	21,37	STAT1	interferon-gamma	20846(Tax:10090)	15978(Tax:10090)	Gene	Gene	nitration|nmod|START_ENTITY tyrosine|dobj|nitration due|xcomp|tyrosine macrophages|amod|due END_ENTITY|nmod|macrophages	Impaired response to interferon-gamma in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric_oxide .
11756175	0	STAT1	114,119	interferon-gamma	146,162	STAT1	interferon-gamma	6772	3458	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nmod|secretion secretion|nmod|END_ENTITY	Human_T-cell_leukemia_virus_type_2 induces survival and proliferation of CD34 -LRB- + -RRB- TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte_macrophage-colony-stimulating_factor .
15284232	0	STAT1	26,31	interferon-gamma	57,73	STAT1	interferon-gamma	20846(Tax:10090)	15978(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Alternative activation of STAT1 and STAT3 in response to interferon-gamma .
17116388	0	STAT1	102,107	interferon-gamma	22,38	STAT1	interferon-gamma	25124(Tax:10116)	25712(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|nmod|END_ENTITY	Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression .
17201122	0	STAT1	73,78	interferon-gamma	33,49	STAT1	interferon-gamma	6772	3458	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death .
19018808	0	STAT1	65,70	interferon-gamma	23,39	STAT1	interferon-gamma	20846(Tax:10090)	15978(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY action|nmod|modulation action|amod|END_ENTITY	Pravastatin attenuates interferon-gamma action via modulation of STAT1 to prevent aortic_atherosclerosis in apolipoprotein_E-knockout mice .
19781632	0	STAT1	121,126	interferon-gamma	26,42	STAT1	interferon-gamma	6772	3458	Gene	Gene	activity|compound|START_ENTITY dynamics|nmod|activity reflects|dobj|dynamics reflects|nsubj|modelling modelling|nmod|signalling signalling|amod|END_ENTITY	Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity .
23942267	0	STAT1	93,98	interferon-gamma	25,41	STAT1	interferon-gamma	6772	3458	Gene	Gene	expression|nmod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	Sodium_butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal_carcinoma cells .
12432235	0	STAT1	60,65	interferon_consensus_sequence_binding_protein	94,139	STAT1	interferon consensus sequence binding protein	20846(Tax:10090)	15900(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	CpG DNA induced IL-12_p40 gene activation is independent of STAT1 activation or production of interferon_consensus_sequence_binding_protein .
20825659	0	STAT1	143,148	interferon_regulatory_factor_1	181,211	STAT1	interferon regulatory factor 1	6772	3659	Gene	Gene	signal_transducer_and_activator_of_transcription_1|appos|START_ENTITY signal_transducer_and_activator_of_transcription_1|dep|transcription transcription|nmod|gene gene|amod|END_ENTITY	Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal_transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- - activated transcription of the interferon_regulatory_factor_1 gene -LRB- IRF1 -RRB- .
8663541	0	STAT1	60,65	interferon_regulatory_factor_1	20,50	STAT1	interferon regulatory factor 1	6772	3659	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Cooperative role of interferon_regulatory_factor_1 and p91 -LRB- STAT1 -RRB- response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene .
12634403	0	STAT1	29,34	latent_membrane_protein_1	43,68	STAT1	latent membrane protein 1	6772	9260	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Epstein-Barr_virus regulates STAT1 through latent_membrane_protein_1 .
19965686	0	STAT1	70,75	matrix_metalloproteinase-9	39,65	STAT1	matrix metalloproteinase-9	6772	4318	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	VEGF/VEGFR2 interaction down-regulates matrix_metalloproteinase-9 via STAT1 activation and inhibits B chronic_lymphocytic_leukemia cell migration .
24858600	0	STAT1	0,5	miR-30a	59,66	STAT1	miR-30a	6772	407029	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a .
26617467	0	STAT1	0,5	p53	79,82	STAT1	p53	6772	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	STAT1 inhibits human hepatocellular_carcinoma cell growth through induction of p53 and Fbxw7 .
24825907	0	STAT1	70,75	protein_kinase_C	40,56	STAT1	protein kinase C	6772	112476	Gene	Gene	proteins|compound|START_ENTITY regulation|nmod|proteins regulation|nmod|END_ENTITY	Transcriptional regulation of oncogenic protein_kinase_C -LRB- PKC -RRB- by STAT1 and Sp1 proteins .
11298125	0	STAT1	66,71	signal-transducer_and_activator_of_transcription_1	14,64	STAT1	signal-transducer and activator of transcription 1	6772	6772	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of signal-transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- in pouchitis .
14984365	0	STAT1	62,67	signal_transducer_and_activator_of_transcription_1	69,119	STAT1	signal transducer and activator of transcription 1	25124(Tax:10116)	25124(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Hypoxia/re-oxygenation-induced , redox-dependent activation of STAT1 -LRB- signal_transducer_and_activator_of_transcription_1 -RRB- confers resistance to apoptotic cell death via hsp70 induction .
17033032	0	STAT1	67,72	signal_transducer_and_activator_of_transcription_1	15,65	STAT1	signal transducer and activator of transcription 1	510814(Tax:9913)	510814(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of the signal_transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- gene on milk production traits in Holstein dairy cattle .
24242046	0	STAT1/3	126,133	Interleukin-6	0,13	STAT1/3	Interleukin-6	6772;6774	3569	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|inhibition inhibition|amod|END_ENTITY	Interleukin-6 inhibition of peroxisome_proliferator-activated_receptor_alpha expression is mediated by JAK2 - and PI3K-induced STAT1/3 in HepG2 hepatocyte cells .
22754757	0	STAT1/3	12,19	gp130	37,42	STAT1/3	gp130	20846;20848	16195(Tax:10090)	Gene	Gene	sites|nummod|START_ENTITY sites|nmod|END_ENTITY	Mutation of STAT1/3 binding sites in gp130 -LRB- FXXQ -RRB- knock-in mice does not alter hematopoietic stem cell repopulation or self-renewal potential .
9950769	0	STAT2	37,42	EGF	0,3	STAT2	EGF	288774(Tax:10116)	25313(Tax:10116)	Gene	Gene	translocation|nmod|START_ENTITY induces|dobj|translocation induces|nsubj|END_ENTITY	EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells .
22426484	0	STAT2	25,30	FBW7	105,109	STAT2	FBW7	6773	55294	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7 .
22305621	0	STAT2	91,96	Oas1b	113,118	STAT2	Oas1b	20847(Tax:10090)	23961(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation .
22824807	0	STAT2	89,94	Pold2	18,23	STAT2	Pold2	6773	5425	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Pold2 as a novel interaction partner of protein inhibitor of activated STAT2 .
24726897	0	STAT3	43,48	AAG8	0,4	STAT3	AAG8	6774	10280	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	AAG8 promotes carcinogenesis by activating STAT3 .
18096869	0	STAT3	0,5	ABCA3	16,21	STAT3	ABCA3	20848(Tax:10090)	27410(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells .
14506160	0	STAT3	77,82	ALK	86,89	STAT3	ALK	6774	238	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK + and ALK - anaplastic_large_cell_lymphoma .
25096061	0	STAT3	30,35	ATF3	110,114	STAT3	ATF3	6774	467	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2 .
26307676	0	STAT3	15,20	Anxa2	0,5	STAT3	Anxa2	6774	302	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast_cancer cells .
23968646	0	STAT3	72,77	BACE1	48,53	STAT3	BACE1	6774	23621	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|regulation regulation|nmod|END_ENTITY	Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes .
26245900	0	STAT3	53,58	BCL-XL	34,40	STAT3	BCL-XL	6774	598	Gene	Gene	Protein|nmod|START_ENTITY Protein|compound|END_ENTITY	The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism .
12821944	0	STAT3	40,45	BCR-ABL	49,56	STAT3	BCR-ABL	6774	25	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells .
19265112	0	STAT3	18,23	CCL11	43,48	STAT3	CCL11	6774	6356	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	Critical role for STAT3 in IL-17A-mediated CCL11 expression in human airway_smooth_muscle cells .
20169197	0	STAT3	34,39	CCL11	13,18	STAT3	CCL11	6774	6356	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	IL-9 induces CCL11 expression via STAT3 signalling in human airway_smooth_muscle cells .
25231320	0	STAT3	84,89	CCL5	50,54	STAT3	CCL5	6774	6352	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Tunicamycin-induced ER stress regulates chemokine CCL5 expression and secretion via STAT3 followed by decreased transmigration of MCF-7 breast_cancer cells .
26983899	0	STAT3	113,118	CCL5	18,22	STAT3	CCL5	6774	6352	Gene	Gene	regulation|nmod|START_ENTITY ovarian_cancer|nmod|regulation cisplatin-resistance|nmod|ovarian_cancer promotes|xcomp|cisplatin-resistance promotes|nsubj|secretion secretion|compound|END_ENTITY	Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovarian_cancer via regulation of the STAT3 and PI3K/Akt signaling pathways .
26770182	0	STAT3	142,147	CD103	72,77	STAT3	CD103	20848(Tax:10090)	16407(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY END_ENTITY|dep|Phosphorylation	3,3 ' - Diindolylmethane Inhibits Flt3L/GM-CSF-induced - bone Marrow-derived CD103 -LRB- + -RRB- Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5 .
18025205	0	STAT3	8,13	CD25	21,25	STAT3	CD25	20848(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
19088198	0	STAT3	41,46	CD274	87,92	STAT3	CD274	6774	29126	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 -LRB- PD-L1 , B7-H1 -RRB- .
17697673	0	STAT3	12,17	CD4	53,56	STAT3	CD4	20848(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Foxp3 Foxp3|compound|END_ENTITY	The role of STAT3 in antigen-IgG inducing regulatory CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- T cells .
18025205	0	STAT3	8,13	CD4	17,20	STAT3	CD4	20848(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
18424728	0	STAT3	8,13	CD4	17,20	STAT3	CD4	20848(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Loss of STAT3 in CD4 + T cells prevents development of experimental autoimmune_diseases .
19648026	0	STAT3	0,5	CD4	9,12	STAT3	CD4	6774	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	STAT3 in CD4 + T helper cell differentiation and inflammatory diseases .
19995899	0	STAT3	0,5	CD4	19,22	STAT3	CD4	20848(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	STAT3 signaling in CD4 + T cells is critical for the pathogenesis of chronic_sclerodermatous_graft-versus-host_disease in a murine model .
21085192	0	STAT3	55,60	CD4	26,29	STAT3	CD4	6774	920	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|cells cells|compound|END_ENTITY	MicroRNA-21 expression in CD4 + T cells is regulated by STAT3 and is pathologically involved in S zary syndrome .
21453726	0	STAT3	66,71	CD4	37,40	STAT3	CD4	6774	920	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|dobj|expression expression|nmod|cells cells|nummod|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
22532634	0	STAT3	93,98	CD4	2,5	STAT3	CD4	6774	920	Gene	Gene	signalling|compound|START_ENTITY implicates|dobj|signalling implicates|nsubj|signature signature|compound|END_ENTITY	A CD4 T cell gene signature for early rheumatoid_arthritis implicates interleukin_6-mediated STAT3 signalling , particularly in anti-citrullinated peptide antibody-negative disease .
23923047	0	STAT3	0,5	CD4	61,64	STAT3	CD4	6774	920	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling induces|dobj|differentiation differentiation|dep|cells cells|compound|END_ENTITY	STAT3 signaling induces the differentiation of human ICOS -LRB- + -RRB- CD4 T cells helping B lymphocytes .
24816405	0	STAT3	62,67	CD4	8,11	STAT3	CD4	6774	920	Gene	Gene	activation|compound|START_ENTITY stemness|nmod|activation promote|dobj|stemness T|ccomp|promote T|nsubj|END_ENTITY	IL-22 -LRB- + -RRB- CD4 -LRB- + -RRB- T cells promote colorectal_cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L .
25663681	0	STAT3	12,17	CD4	0,3	STAT3	CD4	6774	920	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	CD4 + T cell STAT3 phosphorylation precedes acute GVHD , and subsequent Th17 tissue invasion correlates with GVHD severity and therapeutic response .
25880754	0	STAT3	65,70	CD4	0,3	STAT3	CD4	6774	920	Gene	Gene	regulation|nmod|START_ENTITY reveals|dobj|regulation transcriptome|ccomp|reveals transcriptome|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid_arthritis : evidence from a case-control study .
25880754	0	STAT3	65,70	CD4	0,3	STAT3	CD4	6774	920	Gene	Gene	regulation|nmod|START_ENTITY reveals|dobj|regulation transcriptome|ccomp|reveals transcriptome|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 T-cell transcriptome analysis reveals aberrant regulation of STAT3 and Wnt signaling pathways in rheumatoid_arthritis : evidence from a case-control study .
26353115	0	STAT3	13,18	CD4	50,53	STAT3	CD4	6774	920	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|Associates Associates|compound|END_ENTITY	Constitutive STAT3 Phosphorylation in Circulating CD4 + T Lymphocytes Associates with Disease Activity and Treatment Response in Recent-Onset Rheumatoid_Arthritis .
23830147	0	STAT3	52,57	CD8	131,134	STAT3	CD8	6774	925	Gene	Gene	Signal_transducer_and_activator_of_transcription_3|appos|START_ENTITY mutations|nsubj|Signal_transducer_and_activator_of_transcription_3 mutations|dobj|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- mutations underlying autosomal dominant hyper-IgE_syndrome impair human CD8 -LRB- + -RRB- T-cell memory formation and function .
24204098	0	STAT3	0,5	CD8	46,49	STAT3	CD8	6774	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	STAT3 regulates proliferation and survival of CD8 + T cells : enhances effector responses to HSV-1_infection , and inhibits IL-10 + regulatory CD8 + T cells in autoimmune uveitis .
26025380	0	STAT3	0,5	CD8	9,12	STAT3	CD8	6774	925	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	STAT3 in CD8 + T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis .
10660304	0	STAT3	49,54	CNTF	62,66	STAT3	CNTF	6774	1270	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR .
22814105	0	STAT3	57,62	CTGF	37,41	STAT3	CTGF	6774	1490	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Oncostatin_M inhibits TGF-b1-induced CTGF expression via STAT3 in human proximal tubular cells .
21821779	0	STAT3	77,82	CXCR4	6,11	STAT3	CXCR4	20848(Tax:10090)	12767(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	SDF-1 / CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury .
22977534	0	STAT3	38,43	CXCR4	16,21	STAT3	CXCR4	6774	7852	Gene	Gene	expression|compound|START_ENTITY phosphorylated|dobj|expression phosphorylated|nsubj|Significance Significance|nmod|END_ENTITY	Significance of CXCR4 , phosphorylated STAT3 and VEGF-A expression in resected non-small_cell_lung_cancer .
22406084	0	STAT3	105,110	Caveolin-1	0,10	STAT3	Caveolin-1	6774	857	Gene	Gene	signaling|compound|START_ENTITY inhibition|nmod|signaling cells|nmod|inhibition proliferation|nmod|cells arrests|dep|proliferation arrests|amod|END_ENTITY	Caveolin-1 silencing arrests the proliferation of metastatic lung_cancer cells through the inhibition of STAT3 signaling .
19427337	0	STAT3	25,30	Caveolin-2	0,10	STAT3	Caveolin-2	6774	858	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Caveolin-2 regulation of STAT3 transcriptional activation in response to insulin .
17145757	0	STAT3	15,20	Cdk5	0,4	STAT3	Cdk5	6774	1020	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Cdk5 regulates STAT3 activation and cell proliferation in medullary_thyroid_carcinoma cells .
23941877	0	STAT3	117,122	Cyclin-dependent_kinase_5	0,25	STAT3	Cyclin-dependent kinase 5	6774	1020	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 modulates STAT3 and androgen_receptor activation through phosphorylation of Ser on STAT3 in prostate_cancer cells .
23941877	0	STAT3	36,41	Cyclin-dependent_kinase_5	0,25	STAT3	Cyclin-dependent kinase 5	6774	1020	Gene	Gene	activation|compound|START_ENTITY modulates|dobj|activation modulates|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 modulates STAT3 and androgen_receptor activation through phosphorylation of Ser on STAT3 in prostate_cancer cells .
16861352	0	STAT3	0,5	DNMT1	65,70	STAT3	DNMT1	6774	1786	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|transcription transcription|nmod|gene gene|appos|END_ENTITY	STAT3 induces transcription of the DNA methyltransferase 1 gene -LRB- DNMT1 -RRB- in malignant T lymphocytes .
24675762	0	STAT3	121,126	DNMT1	111,116	STAT3	DNMT1	6774	1786	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Kaposi 's _ sarcoma-associated_herpesvirus _ -LRB- KSHV -RRB- vIL-6 promotes cell proliferation and migration by upregulating DNMT1 via STAT3 activation .
26847351	0	STAT3	53,58	DNMT1	73,78	STAT3	DNMT1	6774	1786	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Transcriptional repression of SOCS3 mediated by IL-6 / STAT3 signaling via DNMT1 promotes pancreatic_cancer growth and metastasis .
16452319	0	STAT3	15,20	Duplin	33,39	STAT3	Duplin	20848(Tax:10090)	67772(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Suppression of STAT3 activity by Duplin , which is a negative regulator of the Wnt signal .
19032945	0	STAT3	43,48	EBNA2	27,32	STAT3	EBNA2	6774	17494192	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Epstein-Barr_virus-derived EBNA2 regulates STAT3 activation .
23416296	0	STAT3	21,26	ECHS1	0,5	STAT3	ECHS1	6774	1892	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling .
11713584	0	STAT3	29,34	EGFR	0,4	STAT3	EGFR	6774	1956	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	EGFR dependent expression of STAT3 -LRB- but not STAT1 -RRB- in breast_cancer .
17146292	0	STAT3	14,19	EGFR	85,89	STAT3	EGFR	6774	1956	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|correlation correlation|nmod|status status|amod|END_ENTITY	Activation of STAT3 , MAPK , and AKT in malignant astrocytic_gliomas : correlation with EGFR status , tumor grade , and survival .
18060032	0	STAT3	44,49	EGFR	17,21	STAT3	EGFR	6774	1956	Gene	Gene	activation|nummod|START_ENTITY mediate|dobj|activation mediate|nsubj|Mutations Mutations|nmod|domain domain|amod|END_ENTITY	Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung_adenocarcinomas .
19148533	0	STAT3	35,40	EGFR	10,14	STAT3	EGFR	6774	1956	Gene	Gene	activation|compound|START_ENTITY immunoexpression|nmod|activation immunoexpression|nsubj|Impact Impact|nmod|END_ENTITY	Impact of EGFR immunoexpression on STAT3 activation and association with proinflammatory/regulatory cytokine pattern in laryngeal_squamous_cell_carcinoma .
21856923	0	STAT3	45,50	EGFR	15,19	STAT3	EGFR	25125(Tax:10116)	24329(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Transactivated EGFR mediates a - AR-induced STAT3 activation and cardiac_hypertrophy .
22693070	0	STAT3	80,85	EGFR	45,49	STAT3	EGFR	6774	1956	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nmod|END_ENTITY	STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 .
25695284	0	STAT3	158,163	EGFR	75,79	STAT3	EGFR	6774	1956	Gene	Gene	activating|dobj|START_ENTITY chemoresistance|advcl|activating induces|xcomp|chemoresistance induces|nsubj|exposure exposure|dep|END_ENTITY	Continuous exposure of non __ - small_cell_lung_cancer cells with wild - type EGFR to an inhibitor of EGFR tyrosine kinase induces chemoresistance by activating STAT3 .
25695284	0	STAT3	158,163	EGFR	99,103	STAT3	EGFR	6774	1956	Gene	Gene	activating|dobj|START_ENTITY chemoresistance|advcl|activating induces|xcomp|chemoresistance induces|nsubj|exposure exposure|nmod|kinase kinase|amod|END_ENTITY	Continuous exposure of non __ - small_cell_lung_cancer cells with wild - type EGFR to an inhibitor of EGFR tyrosine kinase induces chemoresistance by activating STAT3 .
26853466	0	STAT3	24,29	EGFR	90,94	STAT3	EGFR	6774	1956	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|glioblastoma glioblastoma|nmod|END_ENTITY	HDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN : new opportunities for selected targeted therapies .
21056972	0	STAT3	120,125	ERK	59,62	STAT3	ERK	20848(Tax:10090)	26413(Tax:10090)	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	Opposing actions of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in regulating microtubule stabilization during cardiac_hypertrophy .
15115615	0	STAT3	42,47	ERK1/2	0,6	STAT3	ERK1/2	6774	5595;5594	Gene	Gene	activity|nummod|START_ENTITY contributes|nmod|activity contributes|nsubj|END_ENTITY	ERK1/2 contributes negative regulation to STAT3 activity in HSS-transfected HepG2 cells .
24819473	0	STAT3	63,68	ERK1/2	92,98	STAT3	ERK1/2	20848(Tax:10090)	26417;26413	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K .
19995546	0	STAT3	63,68	ERp57	8,13	STAT3	ERp57	6774	2923	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Role of ERp57 in the signaling and transcriptional activity of STAT3 in a melanoma cell line .
20022947	0	STAT3	16,21	ERp57	0,5	STAT3	ERp57	20848(Tax:10090)	14827(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	ERp57 modulates STAT3 signaling from the lumen of the endoplasmic reticulum .
25605256	0	STAT3	16,21	ERp57	0,5	STAT3	ERp57	6774	2923	Gene	Gene	activity|nummod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	ERp57 modulates STAT3 activity in radioresistant laryngeal_cancer cells and serves as a prognostic marker for laryngeal_cancer .
14586404	0	STAT3	47,52	ErbB-2	19,25	STAT3	ErbB-2	6774	2064	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic_cancer cell lines .
19524687	0	STAT3	125,130	Erk1/2	102,108	STAT3	Erk1/2	6774	5595;5594	Gene	Gene	downregulating|nmod|START_ENTITY downregulating|dobj|activation activation|nmod|Akt Akt|compound|END_ENTITY	Restoration of SOCS3 suppresses human lung_adenocarcinoma cell growth by downregulating activation of Erk1/2 , Akt apart from STAT3 .
25174327	0	STAT3	36,41	Erk1/2	0,6	STAT3	Erk1/2	6774	5595;5594	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Erk1/2 activation and modulation of STAT3 signaling in oral_cancer .
26563310	0	STAT3	45,50	Erythropoietin	0,14	STAT3	Erythropoietin	20848(Tax:10090)	13856(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response .
18025205	0	STAT3	8,13	FOXP3	26,31	STAT3	FOXP3	20848(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	Role of STAT3 in CD4 + CD25 + FOXP3 + regulatory lymphocyte generation : implications in graft-versus-host_disease and antitumor immunity .
24315995	0	STAT3	44,49	FoxP3	0,5	STAT3	FoxP3	6774	50943	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells .
25200186	0	STAT3	42,47	GPR30	0,5	STAT3	GPR30	20848(Tax:10090)	76854(Tax:10090)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	GPR30 mediates anorectic estrogen-induced STAT3 signaling in the hypothalamus .
17626740	0	STAT3	53,58	GRIM-19	17,24	STAT3	GRIM-19	6774	51079	Gene	Gene	START_ENTITY|nsubj|Correlations Correlations|nmod|END_ENTITY	-LSB- Correlations of GRIM-19 and its target gene product STAT3 to malignancy of human colorectal_carcinoma -RSB- .
23124042	0	STAT3	21,26	GRIM-19	0,7	STAT3	GRIM-19	6774	51079	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric_cancer cells to radiation .
23271731	0	STAT3	39,44	GRIM-19	74,81	STAT3	GRIM-19	6774	51079	Gene	Gene	import|nmod|START_ENTITY depends|nsubj|import depends|nmod|END_ENTITY	The import of the transcription factor STAT3 into mitochondria depends on GRIM-19 , a component of the electron transport chain .
23386605	0	STAT3	169,174	GRIM-19	91,98	STAT3	GRIM-19	6774	51079	Gene	Gene	anti-signal_transducer_and_activator_of_transcription_3|dep|START_ENTITY activity|amod|anti-signal_transducer_and_activator_of_transcription_3 disrupt|dobj|activity disrupt|nsubj|mutations mutations|nmod|gene gene|acl|associated associated|nmod|mortality mortality|appos|END_ENTITY	Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality -LRB- GRIM-19 -RRB- disrupt its anti-signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activity and promote oncogenesis .
23618357	0	STAT3	46,51	GRIM-19	19,26	STAT3	GRIM-19	6774	51079	Gene	Gene	overexpression|nummod|START_ENTITY associated|nmod|overexpression associated|nsubjpass|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast_carcinomas .
14551213	0	STAT3	42,47	Galpha16	22,30	STAT3	Galpha16	6774	2769	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK - _ and_ERK-dependent mechanism .
24037855	0	STAT3	73,78	Gankyrin	0,8	STAT3	Gankyrin	6774	5716	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Gankyrin promotes tumor growth and metastasis through activation of IL-6 / STAT3 signaling in human cholangiocarcinoma .
25613134	0	STAT3	0,5	Glial_Fibrillary_Acidic_Protein	83,114	STAT3	Glial Fibrillary Acidic Protein	6774	2670	Gene	Gene	Involved|nsubjpass|START_ENTITY Involved|nmod|Transactivation Transactivation|nmod|END_ENTITY	STAT3 and its Phosphorylation are Involved in HIV-1 Tat-induced Transactivation of Glial_Fibrillary_Acidic_Protein .
25340554	0	STAT3	73,78	Glycoprotein_130	37,53	STAT3	Glycoprotein 130	6774	3572	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	The Inhibition of N-Glycosylation of Glycoprotein_130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
17822789	0	STAT3	23,28	HB-EGF	0,6	STAT3	HB-EGF	6774	1839	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell .
19121623	0	STAT3	36,41	HDAC3	0,5	STAT3	HDAC3	6774	8841	Gene	Gene	phosphorylation|nmod|START_ENTITY influences|dobj|phosphorylation influences|nsubj|END_ENTITY	HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A .
26342546	0	STAT3	68,73	HES5	0,4	STAT3	HES5	6774	388585	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	HES5 promotes cell proliferation and invasion through activation of STAT3 and predicts poor survival_in_hepatocellular_carcinoma .
24054889	0	STAT3	86,91	HLA-G	0,5	STAT3	HLA-G	6774	3135	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	HLA-G regulates the invasive properties of JEG-3 choriocarcinoma cells by controlling STAT3 activation .
20014282	0	STAT3	59,64	Hsp90	36,41	STAT3	Hsp90	20848(Tax:10090)	104434(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|dobj|association association|amod|END_ENTITY	Leukemia_inhibitory_factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells .
22271514	0	STAT3	0,5	Hsp90	30,35	STAT3	Hsp90	6774	3320	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	STAT3 interacts directly with Hsp90 .
23145121	0	STAT3	103,108	Hsp90	58,63	STAT3	Hsp90	6774	3320	Gene	Gene	activation|nmod|START_ENTITY suppress|dobj|activation induces|advcl|suppress induces|nmod|END_ENTITY	Luteolin induces carcinoma cell apoptosis through binding Hsp90 to suppress constitutive activation of STAT3 .
8626489	0	STAT3	22,27	IFNAR-1	37,44	STAT3	IFNAR-1	6774	3454	Gene	Gene	association|nmod|START_ENTITY association|nmod|chain chain|compound|END_ENTITY	Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor .
15034082	0	STAT3	15,20	IL-10	39,44	STAT3	IL-10	6774	3586	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of STAT3 for production of IL-10 by colon_carcinoma cells induced by macrophage-derived IL-6 .
15218058	0	STAT3	40,45	IL-10	19,24	STAT3	IL-10	20848(Tax:10090)	16153(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression .
17575268	0	STAT3	24,29	IL-10	109,114	STAT3	IL-10	6774	3586	Gene	Gene	START_ENTITY|acl:relcl|kinases kinases|xcomp|promote promote|dobj|production production|compound|END_ENTITY	Acute alcohol activates STAT3 , AP-1 , and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes .
18403020	0	STAT3	8,13	IL-10	64,69	STAT3	IL-10	6774	3586	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene .
19096025	0	STAT3	117,122	IL-10	0,5	STAT3	IL-10	20848(Tax:10090)	16153(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY myocardial_infarction|nmod|activation left|nmod|myocardial_infarction inhibits|ccomp|left inhibits|nsubj|END_ENTITY	IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial_infarction via activation of STAT3 and suppression of HuR .
20356901	0	STAT3	11,16	IL-10	36,41	STAT3	IL-10	6774	3586	Gene	Gene	role|nmod|START_ENTITY role|nmod|down-regulation down-regulation|compound|END_ENTITY	A role for STAT3 and cathepsin_S in IL-10 down-regulation of IFN-gamma-induced MHC class II molecule on primary human blood macrophages .
21286383	0	STAT3	39,44	IL-10	63,68	STAT3	IL-10	6774	3586	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	NDRG2-mediated Modulation of SOCS3 and STAT3 Activity Inhibits IL-10 Production .
21398617	0	STAT3	78,83	IL-10	13,18	STAT3	IL-10	6774	3586	Gene	Gene	activation|compound|START_ENTITY promotes|nmod|activation promotes|dobj|production production|compound|END_ENTITY	CD5 promotes IL-10 production in chronic_lymphocytic_leukemia B cells through STAT3 and NFAT2 activation .
21654841	0	STAT3	70,75	IL-10	20,25	STAT3	IL-10	6774	3586	Gene	Gene	activation|compound|START_ENTITY reduction|nmod|activation permits|dobj|reduction permits|nsubj|variant variant|compound|END_ENTITY	An intracytoplasmic IL-10 receptor variant permits rapid reduction in STAT3 activation .
21792878	0	STAT3	24,29	IL-10	85,90	STAT3	IL-10	6774	3586	Gene	Gene	mutations|nmod|START_ENTITY result|nsubj|mutations result|nmod|impairment impairment|nmod|function function|compound|END_ENTITY	SH2-domain mutations in STAT3 in hyper-IgE_syndrome patients result in impairment of IL-10 function .
24513872	0	STAT3	24,29	IL-10	18,23	STAT3	IL-10	20848(Tax:10090)	16153(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Essential role of IL-10 / STAT3 in chronic stress-induced immune suppression .
24577500	0	STAT3	0,5	IL-10	41,46	STAT3	IL-10	6774	3586	Gene	Gene	activation|nummod|START_ENTITY correlates|nsubj|activation correlates|nmod|release release|amod|END_ENTITY	STAT3 activation by KSHV correlates with IL-10 , IL-6 and IL-23 release and an autophagic_block in dendritic cells .
24737107	0	STAT3	13,18	IL-10	47,52	STAT3	IL-10	6774	3586	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|secretion secretion|compound|END_ENTITY	TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells .
25348624	0	STAT3	89,94	IL-10	60,65	STAT3	IL-10	20848(Tax:10090)	16153(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Interruption of Macrophage-Derived IL-27 -LRB- p28 -RRB- Production by IL-10 during Sepsis Requires STAT3 but Not SOCS3 .
26080800	0	STAT3	0,5	IL-10	72,77	STAT3	IL-10	6774	3586	Gene	Gene	activation|compound|START_ENTITY associated|nsubjpass|activation associated|nmod|interleukin-10 interleukin-10|appos|END_ENTITY	STAT3 activation is associated with cerebrospinal fluid interleukin-10 -LRB- IL-10 -RRB- in primary central nervous system diffuse large B_cell_lymphoma .
26363058	0	STAT3	74,79	IL-10	0,5	STAT3	IL-10	6774	3586	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1 .
26482950	0	STAT3	129,134	IL-10	123,128	STAT3	IL-10	6774	3586	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Tuberculosis is associated with expansion of a motile , permissive and immunomodulatory CD16 -LRB- + -RRB- monocyte population via the IL-10 / STAT3 axis .
16622035	0	STAT3	0,5	IL-17	66,71	STAT3	IL-17	20848(Tax:10090)	16171(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|production production|compound|END_ENTITY	STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice .
23555696	0	STAT3	63,68	IL-17A_and_IFN-y	0,16	STAT3	IL-17A and IFN-y	6774	3605;3458	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	IL-17A_and_IFN-y synergistically induce RNase_7 expression via STAT3 in primary keratinocytes .
12681450	0	STAT3	36,41	IL-2	0,4	STAT3	IL-2	6774	3558	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	IL-2 activation of a PI3K-dependent STAT3 serine phosphorylation pathway in primary human T cells .
19564350	0	STAT3	0,5	IL-22	12,17	STAT3	IL-22	20848(Tax:10090)	50929(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing .
21453726	0	STAT3	66,71	IL-27	0,5	STAT3	IL-27	6774	246778	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	IL-27 suppresses RANKL expression in CD4 + T cells in part through STAT3 .
10611490	0	STAT3	75,80	IL-4	11,15	STAT3	IL-4	6774	3565	Gene	Gene	phosphorylation|compound|START_ENTITY leads|nmod|phosphorylation complex|acl:relcl|leads complex|dep|Binding Binding|nmod|END_ENTITY	Binding of IL-4 to the IL-13Ralpha -LRB- 1 -RRB- / IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation .
11058569	0	STAT3	146,151	IL-4	20,24	STAT3	IL-4	6774	3565	Gene	Gene	activation|compound|START_ENTITY residue|nmod|activation requirement|nmod|residue redundancy|nmod|requirement chain|dep|redundancy dependent|nmod|chain signals|xcomp|dependent signals|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1 : redundancy of requirement of tyrosine residue for STAT3 activation .
12502184	0	STAT3	41,46	IL-4	74,78	STAT3	IL-4	6774	3565	Gene	Gene	activation|compound|START_ENTITY inhibition|nmod|activation modulated|nsubjpass|inhibition modulated|nmod|END_ENTITY	IL-1-mediated inhibition of IL-6-induced STAT3 activation is modulated by IL-4 , MAP kinase inhibitors and redox state of HepG2 cells .
15528381	0	STAT3	67,72	IL-5_and_granulocyte-macrophage_colony-stimulating_factor	0,57	STAT3	IL-5 and granulocyte-macrophage colony-stimulating factor	6774	3567;1437	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	IL-5_and_granulocyte-macrophage_colony-stimulating_factor activate STAT3 and STAT5 and promote Pim-1 and cyclin_D3 protein expression in human eosinophils .
10445852	0	STAT3	94,99	IL-6	51,55	STAT3	IL-6	6774	3569	Gene	Gene	activation|nmod|START_ENTITY induced|dobj|activation END_ENTITY|acl|induced	Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3 .
10720495	0	STAT3	93,98	IL-6	33,37	STAT3	IL-6	6774	3569	Gene	Gene	activation|compound|START_ENTITY causes|dobj|activation causes|nsubj|secretion secretion|nmod|cytokines cytokines|compound|END_ENTITY	Autocrine/Paracrine secretion of IL-6 family cytokines causes angiotensin_II-induced delayed STAT3 activation .
10851053	0	STAT3	9,14	IL-6	102,106	STAT3	IL-6	6774	3569	Gene	Gene	Roles|nmod|START_ENTITY relayed|nsubj|Roles relayed|nmod|family family|compound|END_ENTITY	Roles of STAT3 in mediating the cell growth , differentiation and survival signals relayed through the IL-6 family of cytokine receptors .
11243705	0	STAT3	137,142	IL-6	24,28	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY cells|nmod|activation induces|nmod|cells induces|nsubj|END_ENTITY	Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3 .
11322950	0	STAT3	72,77	IL-6	83,87	STAT3	IL-6	6774	3569	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|stimulation stimulation|compound|END_ENTITY	Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation .
11337018	0	STAT3	0,5	IL-6	61,65	STAT3	IL-6	6774	3569	Gene	Gene	exerts|nsubj|START_ENTITY exerts|nmod|effects effects|nmod|END_ENTITY	STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells .
11356008	0	STAT3	31,36	IL-6	76,80	STAT3	IL-6	6774	3569	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nmod|transactivation transactivation|nmod|element element|amod|respone respone|amod|END_ENTITY	c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element -LRB- IRE -RRB- .
11470914	0	STAT3	14,19	IL-6	44,48	STAT3	IL-6	6774	3569	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nmod|END_ENTITY	Rac1 mediates STAT3 activation by autocrine IL-6 .
11710966	0	STAT3	18,23	IL-6	0,4	STAT3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells .
11890706	0	STAT3	56,61	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	proto-oncogene|nmod|START_ENTITY expression|nmod|proto-oncogene induces|dobj|expression induces|nsubj|END_ENTITY	IL-6 induces expression of the Fli-1 proto-oncogene via STAT3 .
12015387	0	STAT3	59,64	IL-6	31,35	STAT3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	translocation|compound|START_ENTITY END_ENTITY|nmod|translocation	Selected contribution : role of IL-6 in LPS-induced nuclear STAT3 translocation in sensory circumventricular organs during fever in rats .
12360405	0	STAT3	28,33	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells .
15034082	0	STAT3	15,20	IL-6	100,104	STAT3	IL-6	6774	3569	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|acl|induced induced|nmod|END_ENTITY	Recruitment of STAT3 for production of IL-10 by colon_carcinoma cells induced by macrophage-derived IL-6 .
15356132	0	STAT3	62,67	IL-6	0,4	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation .
15976028	0	STAT3	25,30	IL-6	0,4	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	trans-signaling|nmod|START_ENTITY trans-signaling|compound|END_ENTITY	IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation .
16399222	0	STAT3	61,66	IL-6	15,19	STAT3	IL-6	6774	3569	Gene	Gene	activation|compound|START_ENTITY blocking|dobj|activation production|acl|blocking production|compound|END_ENTITY	Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant_soft_tissue_tumor cells .
16718380	0	STAT3	81,86	IL-6	0,4	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	N-domain|compound|START_ENTITY analysis|nmod|N-domain signaling|dep|analysis signaling|compound|END_ENTITY	IL-6 signaling via the STAT3/SOCS3 pathway : functional analysis of the conserved STAT3 N-domain .
17082315	0	STAT3	27,32	IL-6	52,56	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	consequences|nmod|START_ENTITY hyperactivation|nsubj|consequences hyperactivation|nmod|END_ENTITY	Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis .
17510282	0	STAT3	17,22	IL-6	50,54	STAT3	IL-6	6774	3569	Gene	Gene	accumulates|nsubj|START_ENTITY accumulates|nmod|END_ENTITY	Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB .
17822789	0	STAT3	23,28	IL-6	63,67	STAT3	IL-6	6774	3569	Gene	Gene	activation|compound|START_ENTITY activation|nmod|secretion secretion|compound|END_ENTITY	HB-EGF induces delayed STAT3 activation via NF-kappaB mediated IL-6 secretion in vascular smooth muscle cell .
17970038	0	STAT3	46,51	IL-6	41,45	STAT3	IL-6	6774	3569	Gene	Gene	cytokine|nsubj|START_ENTITY strategies|parataxis|cytokine strategies|acl|targeting targeting|dobj|END_ENTITY	Therapeutic strategies for targeting the IL-6 / STAT3 cytokine signaling pathway in inflammatory_bowel_disease .
18060032	0	STAT3	44,49	IL-6	65,69	STAT3	IL-6	6774	3569	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|production production|compound|END_ENTITY	Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung_adenocarcinomas .
18474224	0	STAT3	39,44	IL-6	4,8	STAT3	IL-6	6774	3569	Gene	Gene	activation|compound|START_ENTITY modulates|dobj|activation modulates|nsubj|family family|compound|END_ENTITY	The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction .
18641358	0	STAT3	68,73	IL-6	0,4	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	inflammation|nmod|START_ENTITY regulates|nmod|inflammation regulates|nsubj|END_ENTITY	IL-6 regulates neutrophil trafficking during acute inflammation via STAT3 .
19109195	0	STAT3	58,63	IL-6	25,29	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	control|compound|START_ENTITY signaling|dobj|control trans|xcomp|signaling trans|nsubj|targeting targeting|nmod|END_ENTITY	Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory_arthritis .
19285962	0	STAT3	28,33	IL-6	23,27	STAT3	IL-6	6774	3569	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Capsaicin inhibits the IL-6 / STAT3 pathway by depleting intracellular gp130 pools through endoplasmic_reticulum_stress .
19330073	0	STAT3	117,122	IL-6	152,156	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	signal_transduction_and_activation_of_transcription_3|appos|START_ENTITY signal_transduction_and_activation_of_transcription_3|acl|attenuate attenuate|dobj|action action|appos|END_ENTITY	Pravastatin prevents aortic_atherosclerosis via modulation of signal_transduction_and_activation_of_transcription_3 -LRB- STAT3 -RRB- to attenuate interleukin-6 -LRB- IL-6 -RRB- action in ApoE knockout mice .
19741197	0	STAT3	86,91	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	cells|nmod|START_ENTITY activity|nmod|cells stimulates|nsubj|activity stimulates|dep|END_ENTITY	IL-6 stimulates system A amino_acid transporter activity in trophoblast cells through STAT3 and increased expression of SNAT2 .
19751774	0	STAT3	17,22	IL-6	43,47	STAT3	IL-6	6774	3569	Gene	Gene	activation|compound|START_ENTITY Visfatin|nmod|activation enhances|nsubj|Visfatin enhances|dobj|expression expression|compound|END_ENTITY	Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis .
20562100	0	STAT3	14,19	IL-6	68,72	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY Inhibition|nmod|signaling blocks|nsubj|Inhibition blocks|dobj|activity activity|nmod|END_ENTITY	Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver_cancer cells .
20818158	0	STAT3	79,84	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	phosphorylation|compound|START_ENTITY factor|dep|phosphorylation factor|dep|END_ENTITY	IL-6 , a risk factor for hepatocellular_carcinoma : FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular_cancer cells .
21148800	0	STAT3	73,78	IL-6	0,4	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY modulates|dobj|responses modulates|nsubj|trans-signaling trans-signaling|compound|END_ENTITY	IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 .
21282107	0	STAT3	55,60	IL-6	115,119	STAT3	IL-6	6774	3569	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Extracellular hepatitis_C_virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway .
21293887	0	STAT3	44,49	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	expression|nmod|START_ENTITY induction|nmod|expression induction|compound|END_ENTITY	IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle .
21619877	0	STAT3	4,9	IL-6	18,22	STAT3	IL-6	6774	3569	Gene	Gene	beacon|compound|START_ENTITY beacon|parataxis|activates activates|nsubj|END_ENTITY	The STAT3 beacon : IL-6 recurrently activates STAT_3 from endosomal structures .
21744993	0	STAT3	42,47	IL-6	69,73	STAT3	IL-6	6774	3569	Gene	Gene	blockage|nmod|START_ENTITY effects|nmod|blockage effects|acl|signaling signaling|nmod|EMT EMT|compound|END_ENTITY	The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic_cancer cells in vitro .
22157761	0	STAT3	66,71	IL-6	99,103	STAT3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_3|appos|START_ENTITY signal_transducer_and_activator_of_transcription_3|appos|END_ENTITY	Inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- attenuates interleukin-6 -LRB- IL-6 -RRB- - induced collagen synthesis and resultant hypertrophy in rat heart .
22194466	0	STAT3	95,100	IL-6	90,94	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Metastatic cells can escape the proapoptotic effects of TNF-a through increased autocrine IL-6 / STAT3 signaling .
22273698	0	STAT3	16,21	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	kinase|compound|START_ENTITY stimulates|dobj|kinase stimulates|nsubj|END_ENTITY	IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic_cancer cell lines .
22394507	0	STAT3	25,30	IL-6	20,24	STAT3	IL-6	6774	3569	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Quercetin abrogates IL-6 / STAT3 signaling and inhibits glioblastoma cell line growth and migration .
22469658	0	STAT3	50,55	IL-6	8,12	STAT3	IL-6	101070968	503562(Tax:31033)	Gene	Gene	signaling|compound|START_ENTITY promotes|nmod|signaling promotes|nsubj|END_ENTITY	Teleost IL-6 promotes antibody production through STAT3 signaling via IL-6R and gp130 .
22581330	0	STAT3	0,5	IL-6	71,75	STAT3	IL-6	6774	3569	Gene	Gene	mutations|compound|START_ENTITY correlated|nsubj|mutations correlated|xcomp|blockage blockage|nmod|STAT3 STAT3|compound|END_ENTITY	STAT3 mutations correlated with hyper-IgE_syndrome lead to blockage of IL-6 / STAT3 signalling pathway .
22585093	0	STAT3	77,82	IL-6	72,76	STAT3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	survival|compound|START_ENTITY survival|compound|END_ENTITY	Proline protects liver from D-galactosamine hepatitis by activating the IL-6 / STAT3 survival signaling pathway .
22743617	0	STAT3	0,5	IL-6	20,24	STAT3	IL-6	6774	3569	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	STAT3 activation by IL-6 from mesenchymal stem cells promotes the proliferation and metastasis of osteosarcoma .
22937006	0	STAT3	116,121	IL-6	62,66	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|dobj|END_ENTITY	Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1b production in macrophages by targeting STAT3 .
23238769	0	STAT3	79,84	IL-6	74,78	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY signals|compound|END_ENTITY	A20 promotes liver_regeneration by decreasing SOCS3 expression to enhance IL-6 / STAT3 proliferative signals .
23408169	0	STAT3	164,169	IL-6	159,163	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Proximal tubule-specific overexpression of netrin-1 suppresses acute_kidney_injury-induced interstitial_fibrosis and glomerulosclerosis through suppression of IL-6 / STAT3 signaling .
23630344	0	STAT3	98,103	IL-6	0,4	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY enhancing|dobj|activation induce|advcl|enhancing G-CSF|xcomp|induce cooperates|advcl|G-CSF cooperates|nsubj|END_ENTITY	IL-6 cooperates with G-CSF to induce protumor function of neutrophils in bone marrow by enhancing STAT3 activation .
24004609	0	STAT3	56,61	IL-6	16,20	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY regulation|nmod|signaling secretion|appos|regulation secretion|compound|END_ENTITY	Arsenite evokes IL-6 secretion , autocrine regulation of STAT3 signaling , and miR-21 expression , processes involved in the EMT and malignant transformation of human bronchial epithelial cells .
24082147	0	STAT3	0,5	IL-6	32,36	STAT3	IL-6	6774	3569	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|response response|nmod|END_ENTITY	STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor .
24082147	0	STAT3	0,5	IL-6	68,72	STAT3	IL-6	6774	3569	Gene	Gene	activation|nummod|START_ENTITY prolonged|nsubj|activation prolonged|nmod|the the|nmod|receptor receptor|compound|END_ENTITY	STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor .
24101153	0	STAT3	111,116	IL-6	106,110	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Generation of prostate_tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6 / STAT3 signaling .
24244348	0	STAT3	27,32	IL-6	14,18	STAT3	IL-6	6774	3569	Gene	Gene	activation|compound|START_ENTITY ensures|dobj|activation ensures|nsubj|END_ENTITY	NF-kB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma .
24473196	0	STAT3	0,5	IL-6	74,78	STAT3	IL-6	6774	3569	Gene	Gene	induction|nummod|START_ENTITY forms|nsubj|induction forms|xcomp|inhibit inhibit|nmod|END_ENTITY	STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-kB to IL-6 signaling axis and STAT3-driven cancer phenotypes .
24682171	0	STAT3	52,57	IL-6	47,51	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY suppresses|nsubj|signaling binder|parataxis|suppresses binder|acl:relcl|blocks blocks|dobj|END_ENTITY	A high-affinity protein binder that blocks the IL-6 / STAT3 signaling pathway effectively suppresses non-small_cell_lung_cancer .
24863036	0	STAT3	27,32	IL-6	22,26	STAT3	IL-6	6774	3569	Gene	Gene	signaling|nsubj|START_ENTITY Angoline|parataxis|signaling Angoline|dep|END_ENTITY	Angoline : a selective IL-6 / STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum .
25136113	0	STAT3	5,10	IL-6	0,4	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	IL-6 / STAT3 promotes regeneration of airway ciliated cells from basal stem cells .
25340554	0	STAT3	73,78	IL-6	93,97	STAT3	IL-6	6774	3569	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|Cytokines Cytokines|compound|END_ENTITY	The Inhibition of N-Glycosylation of Glycoprotein_130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
25481644	0	STAT3	51,56	IL-6	81,85	STAT3	IL-6	6774	3569	Gene	Gene	phosphorylation|compound|START_ENTITY contributes|nmod|phosphorylation contributes|nmod|transactivation transactivation|compound|END_ENTITY	Sphingosine_kinase_1 contributes to leptin-induced STAT3 phosphorylation through IL-6 / gp130 transactivation in oestrogen receptor-negative breast_cancer .
25544427	0	STAT3	19,24	IL-6	14,18	STAT3	IL-6	6774	3569	Gene	Gene	axis|dep|START_ENTITY Inhibition|dep|axis Inhibition|nmod|END_ENTITY	Inhibition of IL-6 / STAT3 axis and targeting Axl and Tyro3 receptor tyrosine kinases by apigenin circumvent taxol resistance in ovarian_cancer cells .
25604648	0	STAT3	5,10	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY contributes|nsubj|signaling END_ENTITY|appos|contributes	IL-6 / STAT3 signaling pathway contributes to chondrogenic differentiation of human mesenchymal stem cells .
25713055	0	STAT3	96,101	IL-6	91,95	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY suppression|parataxis|signaling suppression|nmod|END_ENTITY	15-Lipoxygenase-1 suppression of colitis-associated colon_cancer through inhibition of the IL-6 / STAT3 signaling pathway .
25750173	0	STAT3	35,40	IL-6	30,34	STAT3	IL-6	6774	3569	Gene	Gene	transactivation|compound|START_ENTITY promotes|nsubj|transactivation Aberrantly|parataxis|promotes Aberrantly|acl|expressed expressed|nmod|END_ENTITY	Aberrantly expressed Fra-1 by IL-6 / STAT3 transactivation promotes colorectal_cancer_aggressiveness through epithelial-mesenchymal transition .
25826381	0	STAT3	85,90	IL-6	105,109	STAT3	IL-6	6774	3569	Gene	Gene	Activation|compound|START_ENTITY N-Glycosylation|nmod|Activation Inhibition|nmod|N-Glycosylation Inhibition|nmod|Cytokines Cytokines|compound|END_ENTITY	Correction : The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes .
26019757	0	STAT3	31,36	IL-6	26,30	STAT3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY Alterations|dep|Signaling Alterations|nmod|END_ENTITY	Epigenetic Alterations of IL-6 / STAT3 Signaling by Placental Stem Cells Promote Hepatic Regeneration in a Rat Model with CCl4-induced Liver_Injury .
26019757	0	STAT3	31,36	IL-6	26,30	STAT3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY Alterations|dep|Signaling Alterations|nmod|END_ENTITY	Epigenetic Alterations of IL-6 / STAT3 Signaling by Placental Stem Cells Promote Hepatic Regeneration in a Rat Model with CCl4-induced Liver_Injury .
26062544	0	STAT3	43,48	IL-6	38,42	STAT3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	pathway|nummod|START_ENTITY effect|dep|pathway effect|nmod|END_ENTITY	Hepato-protective effect of rutin via IL-6 / STAT3 pathway in CCl4-induced hepatotoxicity in rats .
26101800	0	STAT3	9,14	IL-6	4,8	STAT3	IL-6	6774	3569	Gene	Gene	pathway|nummod|START_ENTITY involved|nsubjpass|pathway END_ENTITY|parataxis|involved	The IL-6 / STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes .
26166037	0	STAT3	49,54	IL-6	59,63	STAT3	IL-6	6774	3569	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6 / JAK1/STAT3 signal pathway in Gefitinib-resistant lung_cancer cells .
26452542	0	STAT3	44,49	IL-6	39,43	STAT3	IL-6	6774	3569	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Long noncoding RNA lncTCF7 , induced by IL-6 / STAT3 transactivation , promotes hepatocellular_carcinoma aggressiveness through epithelial-mesenchymal transition .
26484199	0	STAT3	68,73	IL-6	89,93	STAT3	IL-6	6774	3569	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|axis axis|compound|END_ENTITY	Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6 / IL-6Ra axis .
26587789	0	STAT3	86,91	IL-6	81,85	STAT3	IL-6	6774	3569	Gene	Gene	Pathway|compound|START_ENTITY Contributes|dep|Pathway Contributes|nmod|Degradation Degradation|nmod|END_ENTITY	Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6 / STAT3 Signalling Pathway in Human Intervertebral Disc Degeneration .
26711554	0	STAT3	76,81	IL-6	71,75	STAT3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	pathway|nummod|START_ENTITY Suppression|dep|pathway Suppression|nmod|END_ENTITY	Suppression of colitis-associated_carcinogenesis through modulation of IL-6 / STAT3 pathway by Balsalazide and VSL # 3 .
26722442	0	STAT3	5,10	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY activated|nsubjpass|signaling END_ENTITY|appos|activated	IL-6 / STAT3 signaling pathway is activated in plasma cell mastitis .
26738736	0	STAT3	5,10	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	Plays|nsubj|START_ENTITY END_ENTITY|appos|Plays	IL-6 / STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells .
26812074	0	STAT3	68,73	IL-6	63,67	STAT3	IL-6	6774	3569	Gene	Gene	axis|compound|START_ENTITY axis|compound|END_ENTITY	Long non-coding RNA DILC regulates liver_cancer stem cells via IL-6 / STAT3 axis .
26847351	0	STAT3	53,58	IL-6	48,52	STAT3	IL-6	6774	3569	Gene	Gene	signaling|compound|START_ENTITY promotes|nsubj|signaling repression|parataxis|promotes repression|acl|mediated mediated|nmod|END_ENTITY	Transcriptional repression of SOCS3 mediated by IL-6 / STAT3 signaling via DNMT1 promotes pancreatic_cancer growth and metastasis .
26921327	0	STAT3	59,64	IL-6	54,58	STAT3	IL-6	6774	3569	Gene	Gene	START_ENTITY|dep|mediated mediated|nmod|END_ENTITY	Resistance to anti-VEGF therapy mediated by autocrine IL-6 / STAT3 signaling and overcome by IL-6 blockade .
26921327	0	STAT3	59,64	IL-6	91,95	STAT3	IL-6	6774	3569	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|blockade blockade|compound|END_ENTITY	Resistance to anti-VEGF therapy mediated by autocrine IL-6 / STAT3 signaling and overcome by IL-6 blockade .
27006530	0	STAT3	24,29	IL-6	0,4	STAT3	IL-6	6774	3569	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin .
22469658	0	STAT3	50,55	IL-6R	70,75	STAT3	IL-6R	101070968	101069438	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Teleost IL-6 promotes antibody production through STAT3 signaling via IL-6R and gp130 .
26929249	0	STAT3	89,94	IL-6R	57,62	STAT3	IL-6R	6774	3570	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|Chikusetsusaponin Chikusetsusaponin|appos|antagonist antagonist|compound|END_ENTITY	Chikusetsusaponin a butyl_ester -LRB- CS - ___ a-Be -RRB- , a novel IL-6R antagonist , inhibits IL-6 / STAT3 signaling pathway and induces cancer cell apoptosis .
26484199	0	STAT3	68,73	IL-6Ra	94,100	STAT3	IL-6Ra	6774	3570	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|axis axis|compound|END_ENTITY	Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6 / IL-6Ra axis .
20169197	0	STAT3	34,39	IL-9	0,4	STAT3	IL-9	6774	3578	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-9 induces CCL11 expression via STAT3 signalling in human airway_smooth_muscle cells .
19595668	0	STAT3	54,59	IkappaB-zeta	16,28	STAT3	IkappaB-zeta	20848(Tax:10090)	80859(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Nuclear protein IkappaB-zeta inhibits the activity of STAT3 .
15575898	0	STAT3	40,45	Il-6	35,39	STAT3	Il-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|dep|START_ENTITY induces|xcomp|END_ENTITY	Severe preservation injury induces Il-6 / STAT3 activation with lack of cell cycle progression after partial liver graft transplantation .
25476455	0	STAT3	57,62	Inositol_Polyphosphate-5-Phosphatase_F	0,38	STAT3	Inositol Polyphosphate-5-Phosphatase F	6774	22876	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Inositol_Polyphosphate-5-Phosphatase_F -LRB- INPP5F -RRB- inhibits STAT3 activity and suppresses gliomas_tumorigenicity .
19716605	0	STAT3	83,88	Interleukin-11	0,14	STAT3	Interleukin-11	6774	3589	Gene	Gene	expression|compound|START_ENTITY modulating|dobj|expression increases|advcl|modulating increases|nsubj|END_ENTITY	Interleukin-11 increases invasiveness of JEG-3 choriocarcinoma cells by modulating STAT3 expression .
15120652	0	STAT3	25,30	Interleukin-22	0,14	STAT3	Interleukin-22	6774	50616	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells .
21674558	0	STAT3	72,77	Interleukin-22	0,14	STAT3	Interleukin-22	6774	50616	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Interleukin-22 promotes human hepatocellular_carcinoma by activation of STAT3 .
12629515	0	STAT3	82,87	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	pathway|compound|START_ENTITY angiogenesis|nmod|pathway promotes|nmod|angiogenesis promotes|nsubj|END_ENTITY	Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway .
12665506	0	STAT3	73,78	Interleukin-6	0,13	STAT3	Interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|family family|amod|END_ENTITY	Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart .
12865171	0	STAT3	58,63	Interleukin-6	0,13	STAT3	Interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	translocation|compound|START_ENTITY mediates|dobj|translocation mediates|nsubj|END_ENTITY	Interleukin-6 mediates lipopolysaccharide-induced nuclear STAT3 translocation in astrocytes of rat sensory circumventricular organs .
14586407	0	STAT3	113,118	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	activation|nmod|START_ENTITY acts|nmod|activation acts|nsubj|END_ENTITY	Interleukin-6 acts as an antiapoptotic factor in human esophageal_carcinoma cells through the activation of both STAT3 and mitogen-activated protein kinase pathways .
15532800	0	STAT3	91,96	Interleukin-6	0,13	STAT3	Interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY involvement|nmod|activation augments|dep|involvement augments|amod|END_ENTITY	Interleukin-6 augments hepatocyte_growth_factor-induced liver_regeneration ; involvement of STAT3 activation .
16835372	0	STAT3	50,55	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-6 induces hepcidin expression through STAT3 .
17581928	0	STAT3	88,93	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	involvement|nmod|START_ENTITY stimulates|parataxis|involvement stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates alpha-MG uptake in renal proximal tubule cells : involvement of STAT3 , PI3K/Akt , MAPKs , and NF-kappaB .
19020307	0	STAT3	14,19	Interleukin-6	0,13	STAT3	Interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|parataxis|regulates	Interleukin-6 / STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities .
21954831	0	STAT3	78,83	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	phosphorylation|compound|START_ENTITY mediates|nsubj|phosphorylation mediates|dep|autocrine autocrine|nsubj|END_ENTITY	Interleukin-6 autocrine signaling mediates melatonin MT -LRB- 1/2 -RRB- receptor-induced STAT3 Tyr -LRB- 705 -RRB- phosphorylation .
22962574	0	STAT3	76,81	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	activation|nummod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Interleukin-6 induces S100A9 expression in colonic epithelial cells through STAT3 activation in experimental ulcerative_colitis .
23114963	0	STAT3	92,97	Interleukin-6	0,13	STAT3	Interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY role|nmod|pathway differentiation|dep|role promotes|dobj|differentiation promotes|nsubj|END_ENTITY	Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells : role of the STAT3 pathway .
25968456	0	STAT3	14,19	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	Signaling|compound|START_ENTITY Drives|nsubj|Signaling END_ENTITY|parataxis|Drives	Interleukin-6 / STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma .
25968456	0	STAT3	14,19	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	Signaling|compound|START_ENTITY Drives|nsubj|Signaling END_ENTITY|parataxis|Drives	Interleukin-6 / STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma .
26663388	0	STAT3	85,90	Interleukin-6	0,13	STAT3	Interleukin-6	6774	3569	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Interleukin-6 increases expression of serine_protease_inhibitor_Kazal_type_1 through STAT3 in colorectal_adenocarcinoma .
26316892	0	STAT3	35,40	Interleukin_37	0,14	STAT3	Interleukin 37	6774	27178	Gene	Gene	START_ENTITY|nsubj|Inhibits Inhibits|compound|END_ENTITY	Interleukin_37 Expression Inhibits STAT3 to Suppress the Proliferation and Invasion of Human Cervical_Cancer Cells .
23911788	0	STAT3	32,37	JAB1	0,4	STAT3	JAB1	6774	10987	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	JAB1 regulates unphosphorylated STAT3 DNA-binding activity through protein-protein interaction in human colon_cancer cells .
15970430	0	STAT3	82,87	JAK2	53,57	STAT3	JAK2	6774	3717	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2 .
16517948	0	STAT3	93,98	JAK2	71,75	STAT3	JAK2	25125(Tax:10116)	24514(Tax:10116)	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	The JAK/STAT pathway is essential for opioid-induced_cardioprotection : JAK2 as a mediator of STAT3 , Akt , and GSK-3_beta .
19063868	0	STAT3	153,158	JAK2	134,138	STAT3	JAK2	25125(Tax:10116)	24514(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation : central role for JAK2 activation of STAT3 and NF-kappaB .
21993263	0	STAT3	71,76	JAK2	19,23	STAT3	JAK2	6774	3717	Gene	Gene	pathways|compound|START_ENTITY activates|dobj|pathways activates|nsubj|Phosphorylation Phosphorylation|nmod|receptor receptor|amod|END_ENTITY	Phosphorylation of JAK2 by serotonin_5-HT _ -LRB- 2A -RRB- _ receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental_choriocarcinoma cell .
22319590	0	STAT3	0,5	JAK2	22,26	STAT3	JAK2	6774	3717	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small_cell_lung_carcinoma .
24890449	0	STAT3	90,95	JAK2	108,112	STAT3	JAK2	6774	3717	Gene	Gene	inactivation|nmod|START_ENTITY induces|nmod|inactivation induces|advcl|blocking blocking|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Thymoquinone induces apoptosis in human colon_cancer HCT116 cells through inactivation of STAT3 by blocking JAK2 - and Src - mediated phosphorylation of EGF receptor tyrosine kinase .
25107644	0	STAT3	87,92	JAK2	55,59	STAT3	JAK2	6774	3717	Gene	Gene	N|dep|START_ENTITY N|dep|analogues analogues|appos|class class|nmod|inhibitors inhibitors|nummod|END_ENTITY	N -LRB- 6 -RRB- - Substituted adenosine analogues , a novel class of JAK2 inhibitors , potently block STAT3 signaling in human cancer cells .
25619393	0	STAT3	19,24	JAK2	51,55	STAT3	JAK2	6774	3717	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|inactivating inactivating|dobj|END_ENTITY	Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells .
26343046	0	STAT3	128,133	JAK2	105,109	STAT3	JAK2	20848(Tax:10090)	16452(Tax:10090)	Gene	Gene	3|appos|START_ENTITY transcription|dobj|3 kinase|dep|transcription kinase|appos|END_ENTITY	Protective effect of Fenofibrate in renal_ischemia reperfusion injury : Involved in suppressing kinase 2 -LRB- JAK2 -RRB- / transcription 3 -LRB- STAT3 -RRB- / p53 signaling activation .
26936086	0	STAT3	100,105	JAK2	93,97	STAT3	JAK2	6774	3717	Gene	Gene	apoptosis|dep|START_ENTITY apoptosis|nmod|chondrocytes chondrocytes|nmod|model model|nmod|osteoarthritis osteoarthritis|nmod|END_ENTITY	Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2 - STAT3 signaling pathway .
20603212	0	STAT3	34,39	Jak2	73,77	STAT3	Jak2	6774	3717	Gene	Gene	activation|compound|START_ENTITY IL-6-induced|dobj|activation IL-6-induced|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	TGF-beta1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells .
16988490	0	STAT3	30,35	Jmjd1a	18,24	STAT3	Jmjd1a	20848(Tax:10090)	104263(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of Jmjd1a as a STAT3 downstream gene in mES cells .
26245900	0	STAT3	53,58	KRAS	11,15	STAT3	KRAS	6774	3845	Gene	Gene	Protein|nmod|START_ENTITY Protein|compound|END_ENTITY	The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism .
24796733	0	STAT3	0,5	LC3	21,24	STAT3	LC3	6774	84557	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	STAT3 down regulates LC3 to inhibit autophagy and pancreatic_cancer cell growth .
24392029	0	STAT3	122,127	LRP-6	98,103	STAT3	LRP-6	6774	4040	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Syndecan-1 -LRB- CD138 -RRB- modulates triple-negative breast_cancer stem cell properties via regulation of LRP-6 and IL-6-mediated STAT3 signaling .
25313399	0	STAT3	24,29	LY5	41,44	STAT3	LY5	6774	5788	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|Viability Viability|compound|END_ENTITY	A Novel Small Molecular STAT3 Inhibitor , LY5 Inhibits Cell Viability , Cell Migration , And Angiogenesis in Medulloblastoma Cells .
26883202	0	STAT3	23,28	LY5	40,43	STAT3	LY5	6774	5788	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	A novel small molecule STAT3 inhibitor , LY5 , inhibits cell viability , colony_formation , _ and_migration_of_colon_and_liver_cancer cells .
17078813	0	STAT3	18,23	Lck	117,120	STAT3	Lck	6774	3932	Gene	Gene	START_ENTITY|acl:relcl|requires requires|dobj|END_ENTITY	Cr -LRB- VI -RRB- - stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck .
12556536	0	STAT3	82,87	Leptin	0,6	STAT3	Leptin	6774	3952	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Leptin activates the anandamide hydrolase promoter in human T lymphocytes through STAT3 .
17095713	0	STAT3	132,137	Leptin	0,6	STAT3	Leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY leptin_receptor|parataxis|signaling END_ENTITY|dep|leptin_receptor	Leptin regulates neointima formation after arterial_injury through mechanisms independent of blood pressure and the leptin_receptor / STAT3 signaling pathways involved in energy balance .
19203792	0	STAT3	90,95	Leptin	0,6	STAT3	Leptin	6774	3952	Gene	Gene	mechanisms|nummod|START_ENTITY affects|nmod|mechanisms affects|nsubj|END_ENTITY	Leptin affects system A amino_acid transport activity in the human placenta : evidence for STAT3 dependent mechanisms .
21671179	0	STAT3	17,22	Leptin	0,6	STAT3	Leptin	6774	3952	Gene	Gene	pathways|nsubj|START_ENTITY activates|ccomp|pathways activates|nsubj|END_ENTITY	Leptin activates STAT3 and ERK1/2 pathways and induces endometrial_cancer_cell_proliferation .
23216800	0	STAT3	31,36	Leptin	0,6	STAT3	Leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulate|dobj|activation regulate|nsubj|END_ENTITY	Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells .
25550283	0	STAT3	55,60	Leptin	0,6	STAT3	Leptin	25125(Tax:10116)	25608(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY facilitates|dobj|phosphorylation facilitates|nsubj|END_ENTITY	Leptin in the hindbrain facilitates phosphorylation of STAT3 in the hypothalamus .
26341832	0	STAT3	55,60	Leptin	0,6	STAT3	Leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Running|nmod|Signaling Effects|acl|Running Suppresses|dobj|Effects Suppresses|nsubj|END_ENTITY	Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons .
26403688	0	STAT3	65,70	Leptin	0,6	STAT3	Leptin	420027(Tax:9031)	373955(Tax:9031)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Leptin activates chicken growth_hormone promoter without chicken STAT3 in vitro .
26936086	0	STAT3	100,105	Leptin	0,6	STAT3	Leptin	6774	3952	Gene	Gene	apoptosis|dep|START_ENTITY induces|dobj|apoptosis induces|nsubj|END_ENTITY	Leptin induces the apoptosis of chondrocytes in an in vitro model of osteoarthritis via the JAK2 - STAT3 signaling pathway .
12084939	0	STAT3	78,83	Leukemia_inhibitory_factor	0,26	STAT3	Leukemia inhibitory factor	20848(Tax:10090)	16878(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY inhibits|nmod|activation inhibits|nsubj|END_ENTITY	Leukemia_inhibitory_factor inhibits neuronal terminal differentiation through STAT3 activation .
20014282	0	STAT3	59,64	Leukemia_inhibitory_factor	0,26	STAT3	Leukemia inhibitory factor	20848(Tax:10090)	16878(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Leukemia_inhibitory_factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells .
26271643	0	STAT3	101,106	Leukemia_inhibitory_factor	0,26	STAT3	Leukemia inhibitory factor	6774	3976	Gene	Gene	osteosarcoma|nmod|START_ENTITY growth|nmod|osteosarcoma promotes|dobj|growth promotes|nsubj|END_ENTITY	Leukemia_inhibitory_factor promotes tumor growth and metastasis in human osteosarcoma via activating STAT3 .
21444672	0	STAT3	0,5	MEK	29,32	STAT3	MEK	6774	5609	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	STAT3 mediates resistance to MEK inhibitor through microRNA miR-17 .
16044153	0	STAT3	46,51	MEK_kinase_1	0,12	STAT3	MEK kinase 1	6774	4214	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	MEK_kinase_1 is essential for Bcr-Abl-induced STAT3 and self-renewal activity in embryonic_stem cells .
25926075	0	STAT3	90,95	MMP-1	68,73	STAT3	MMP-1	6774	4312	Gene	Gene	Activation|compound|START_ENTITY Expression|nmod|Activation Expression|compound|END_ENTITY	Lung_Adenocarcinomas and Lung_Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation .
26501276	0	STAT3	9,14	MMP-2	50,55	STAT3	MMP-2	6774	4313	Gene	Gene	Upregulation|compound|START_ENTITY Upregulation|nmod|END_ENTITY	Elevated STAT3 Signaling-Mediated Upregulation of MMP-2 / 9 Confers Enhanced Invasion Ability in Multidrug-Resistant Breast Cancer Cells .
23967200	0	STAT3	0,5	MMP3	16,20	STAT3	MMP3	6774	4314	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	STAT3 regulates MMP3 in heme-induced endothelial cell apoptosis .
20113333	0	STAT3	134,139	MPL	14,17	STAT3	MPL	6774	4352	Gene	Gene	expression|nmod|START_ENTITY Screening|dep|expression Screening|nmod|mutations mutations|compound|END_ENTITY	Screening for MPL mutations in essential_thrombocythemia and primary myelofibrosis : normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets .
11553624	0	STAT3	41,46	MSK1	0,4	STAT3	MSK1	20848(Tax:10090)	73086(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells .
19578748	0	STAT3	31,36	MUC1	0,4	STAT3	MUC1	6774	4582	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MUC1 is a downstream target of STAT3 and regulates lung_cancer cell survival and invasion .
25327561	0	STAT3	23,28	MUC1	81,85	STAT3	MUC1	6774	4582	Gene	Gene	activation|nmod|START_ENTITY mediates|nsubj|activation mediates|dobj|resistance resistance|nmod|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression .
24472656	0	STAT3	41,46	MafB	0,4	STAT3	MafB	6774	9935	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	MafB is a downstream target of the IL-10 / STAT3 signaling pathway , involved in the regulation of macrophage de-activation .
26806810	0	STAT3	68,73	MiR-143	0,7	STAT3	MiR-143	6774	406935	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-143 inhibits tumor cell proliferation and invasion by targeting STAT3 in esophageal_squamous_cell_carcinoma .
26707908	0	STAT3	98,103	MicroRNA-124-3p	0,15	STAT3	MicroRNA-124-3p	6774	406909	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-124-3p inhibits the growth and metastasis of nasopharyngeal_carcinoma cells by targeting STAT3 .
21085192	0	STAT3	55,60	MicroRNA-21	0,11	STAT3	MicroRNA-21	6774	406991	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	MicroRNA-21 expression in CD4 + T cells is regulated by STAT3 and is pathologically involved in S zary syndrome .
20113333	0	STAT3	134,139	Mpl	91,94	STAT3	Mpl	6774	4352	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Screening for MPL mutations in essential_thrombocythemia and primary myelofibrosis : normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets .
26582088	0	STAT3	41,46	NANOG	19,24	STAT3	NANOG	20848(Tax:10090)	71950(Tax:10090)	Gene	Gene	Cooperates|nmod|START_ENTITY Cooperates|compound|END_ENTITY	TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice .
24793791	0	STAT3	15,20	NPM	47,50	STAT3	NPM	6774	4869	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer .
22696497	0	STAT3	103,108	Nanog	52,57	STAT3	Nanog	20848(Tax:10090)	71950(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY expression|nmod|phosphorylation expression|amod|END_ENTITY	E-cadherin and , in its absence , N-cadherin promotes Nanog expression in mouse embryonic stem cells via STAT3 phosphorylation .
12396456	0	STAT3	63,68	Nef	36,39	STAT3	Nef	6774	6285	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef mediates activation of STAT3 in immature dendritic cells .
12960275	0	STAT3	58,63	Nef	157,160	STAT3	Nef	6774	156110(Tax:11676)	Gene	Gene	activates|dobj|START_ENTITY activates|parataxis|domains domains|nsubj|involvement involvement|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors : involvement of Nef domains interacting with the cell endocytotic machinery .
12960275	0	STAT3	58,63	Nef	44,47	STAT3	Nef	6774	6285	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- Nef activates STAT3 in primary human monocyte/macrophages through the release of soluble factors : involvement of Nef domains interacting with the cell endocytotic machinery .
25576055	0	STAT3	28,33	Nur77	66,71	STAT3	Nur77	20848(Tax:10090)	15370(Tax:10090)	Gene	Gene	acetylation|compound|START_ENTITY acetylation|nmod|END_ENTITY	Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity .
23172665	0	STAT3	0,5	Oct-1	69,74	STAT3	Oct-1	6774	5451	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1 .
22814105	0	STAT3	57,62	Oncostatin_M	0,12	STAT3	Oncostatin M	6774	5008	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Oncostatin_M inhibits TGF-b1-induced CTGF expression via STAT3 in human proximal tubular cells .
25954856	0	STAT3	23,28	Oncostatin_M	0,12	STAT3	Oncostatin M	6774	5008	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Oncostatin_M activates STAT3 to promote endometrial_cancer_invasion and angiogenesis .
26996579	0	STAT3	0,5	Oncostatin_M	76,88	STAT3	Oncostatin M	6774	5008	Gene	Gene	Implicated|nsubjpass|START_ENTITY Implicated|nmod|END_ENTITY	STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin_M through Induction of Matrix_Metalloproteinases_2_and_9 .
16905269	0	STAT3	34,39	P2Y_and_P2X	88,99	STAT3	P2Y and P2X	25125(Tax:10116)	25265(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	P2 purinergic receptors signal to STAT3 in astrocytes : Difference in STAT3 responses to P2Y_and_P2X receptor activation .
16905269	0	STAT3	69,74	P2Y_and_P2X	88,99	STAT3	P2Y and P2X	25125(Tax:10116)	25265(Tax:10116)	Gene	Gene	responses|nummod|START_ENTITY Difference|nmod|responses astrocytes|dep|Difference STAT3|nmod|astrocytes STAT3|nmod|activation activation|amod|END_ENTITY	P2 purinergic receptors signal to STAT3 in astrocytes : Difference in STAT3 responses to P2Y_and_P2X receptor activation .
25833829	0	STAT3	60,65	PARD3	0,5	STAT3	PARD3	6774	56288	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|compound|END_ENTITY	PARD3 Inactivation in Lung Squamous_Cell_Carcinomas Impairs STAT3 and Promotes Malignant Invasion .
26892021	0	STAT3	15,20	PASD1	0,5	STAT3	PASD1	20848(Tax:10090)	382221(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY promotes|dobj|activity promotes|nsubj|END_ENTITY	PASD1 promotes STAT3 activity and tumor growth by inhibiting TC45-mediated dephosphorylation of STAT3 in the nucleus .
25717101	0	STAT3	9,14	PCBP2	29,34	STAT3	PCBP2	6774	5094	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	Cellular STAT3 functions via PCBP2 to restrain EBV lytic activation in B lymphocytes .
11060035	0	STAT3	42,47	PIAS3	98,103	STAT3	PIAS3	6774	10401	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|interacting interacting|nmod|END_ENTITY	The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3 .
11709556	0	STAT3	19,24	PIAS3	36,41	STAT3	PIAS3	25125(Tax:10116)	83614(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	A new role for the STAT3 inhibitor , PIAS3 : a repressor of microphthalmia_transcription_factor .
14715251	0	STAT3	34,39	PIAS3	70,75	STAT3	PIAS3	6774	10401	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3 .
18581899	0	STAT3	47,52	PIAS3	15,20	STAT3	PIAS3	6774	10401	Gene	Gene	protein|compound|START_ENTITY inhibitor|nmod|protein END_ENTITY|dobj|inhibitor	-LSB- Expression of PIAS3 an inhibitor of activated STAT3 protein in human prostate_cancer -RSB- .
20371673	0	STAT3	101,106	PIAS3	86,91	STAT3	PIAS3	6774	10401	Gene	Gene	transactivation|compound|START_ENTITY inhibits|dobj|transactivation inhibits|nsubj|delivery delivery|nmod|peptide peptide|acl|derived derived|nmod|domain domain|nmod|END_ENTITY	The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death .
20516148	0	STAT3	16,21	PIAS3	62,67	STAT3	PIAS3	20848(Tax:10090)	229615(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nmod|regulation regulation|nmod|END_ENTITY	TRIM8 modulates STAT3 activity through negative regulation of PIAS3 .
21812053	0	STAT3	79,84	PIAS3	20,25	STAT3	PIAS3	6774	10401	Gene	Gene	interaction|nmod|START_ENTITY analysis|nmod|interaction domain|dep|analysis domain|nmod|END_ENTITY	The PINIT domain of PIAS3 : structure-function analysis of its interaction with STAT3 .
23322197	0	STAT3	23,28	PIAS3	69,74	STAT3	PIAS3	6774	10401	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	MicroRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis .
24718277	0	STAT3	115,120	PIAS3	0,5	STAT3	PIAS3	20848(Tax:10090)	229615(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY inhibition|nmod|activation modulating|nmod|inhibition acute_graft-versus-host_disease|advcl|modulating suppresses|xcomp|acute_graft-versus-host_disease suppresses|nsubj|END_ENTITY	PIAS3 suppresses acute_graft-versus-host_disease by modulating effector T and B cell subsets through inhibition of STAT3 activation .
24857987	0	STAT3	35,40	PIAS3	55,60	STAT3	PIAS3	6774	10401	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Down-regulation of ATBF1 activates STAT3 signaling via PIAS3 in pacing-induced HL-1 atrial myocytes .
25124686	0	STAT3	76,81	PIAS3	4,9	STAT3	PIAS3	6774	10401	Gene	Gene	Activation|compound|START_ENTITY Associated|nmod|Activation Associated|nsubj|Expression Expression|compound|END_ENTITY	Low PIAS3 Expression in Malignant_Mesothelioma Is Associated with Increased STAT3 Activation and Poor Patient Survival .
25624051	0	STAT3	108,113	PIAS3	157,162	STAT3	PIAS3	6774	10401	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|induction induction|nmod|END_ENTITY	Ascochlorin , an isoprenoid antibiotic inhibits growth and invasion of hepatocellular_carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3 .
25785044	0	STAT3	23,28	PIAS3	0,5	STAT3	PIAS3	6774	10401	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	PIAS3 , an inhibitor of STAT3 , has intensively negative association with the survival of gastric_cancer .
26432044	0	STAT3	128,133	PIAS3	0,5	STAT3	PIAS3	6774	10401	Gene	Gene	signaling|compound|START_ENTITY inactivation|nmod|signaling Relevance|nmod|inactivation patterns|dep|Relevance patterns|compound|END_ENTITY	PIAS3 , SHP2 and SOCS3 expression patterns in cervical_cancers : Relevance with activation and resveratrol-caused inactivation of STAT3 signaling .
27094369	0	STAT3	21,26	PKC	0,3	STAT3	PKC	25125(Tax:10116)	24681(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PKC interacts with STAT3 and promotes its activation in cardiomyocyte hypertrophy .
21782857	0	STAT3	15,20	PLTP	0,4	STAT3	PLTP	6774	5360	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PLTP regulates STAT3 and NFkB in differentiated THP1 cells and human monocyte-derived macrophages .
25510553	0	STAT3	97,102	POMC	42,46	STAT3	POMC	6774	5443	Gene	Gene	interaction|nmod|START_ENTITY regulates|nmod|interaction regulates|dobj|transcription transcription|compound|END_ENTITY	FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3 .
26563310	0	STAT3	45,50	POMC	25,29	STAT3	POMC	20848(Tax:10090)	18976(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response .
12075083	0	STAT3	32,37	PTEN	0,4	STAT3	PTEN	6774	5728	Gene	Gene	activation|nummod|START_ENTITY regulator|nmod|activation regulator|nsubj|END_ENTITY	PTEN is a negative regulator of STAT3 activation in human_papillomavirus-infected cells .
20797623	0	STAT3	0,5	PTEN	46,50	STAT3	PTEN	6774	5728	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer .
25365510	0	STAT3	24,29	PTEN	118,122	STAT3	PTEN	6774	5728	Gene	Gene	miR-21|nmod|START_ENTITY Proliferation|amod|miR-21 Activation|nmod|Proliferation Apoptosis|nsubj|Activation Apoptosis|nmod|Gene Gene|compound|END_ENTITY	Activation of miR-21 by STAT3 Induces Proliferation and Suppresses Apoptosis in Nasopharyngeal_Carcinoma by Targeting PTEN Gene .
26666444	0	STAT3	150,155	PTEN	24,28	STAT3	PTEN	25125(Tax:10116)	50557(Tax:10116)	Gene	Gene	Pathways|compound|START_ENTITY Akt|dep|Pathways Inhibition|parataxis|Akt Inhibition|nmod|Cardioprotection Cardioprotection|compound|END_ENTITY	Selective Inhibition of PTEN Preserves Ischemic Postconditioning Cardioprotection in STZ-induced Type1 Diabetic Rats : Role of the PI3K / Akt and JAK2 / STAT3 Pathways .
25139404	0	STAT3	60,65	Phosphatase_of_regenerating_liver-3	0,35	STAT3	Phosphatase of regenerating liver-3	6774	11156	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Phosphatase_of_regenerating_liver-3 -LRB- PRL-3 -RRB- is regulated by STAT3 in acute_myeloid_leukemia .
23750710	0	STAT3	27,32	Pin1	18,22	STAT3	Pin1	20848(Tax:10090)	23988(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY END_ENTITY|nmod|signalling	Essential role of Pin1 via STAT3 signalling and mitochondria-dependent pathways in restenosis in type 2 diabetes .
16382134	0	STAT3	15,20	RACK1	0,5	STAT3	RACK1	6774	10399	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	RACK1 recruits STAT3 specifically to insulin_and_insulin-like_growth_factor_1_receptors for activation , which is important for regulating anchorage-independent growth .
23555696	0	STAT3	63,68	RNase_7	40,47	STAT3	RNase 7	6774	84659	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	IL-17A_and_IFN-y synergistically induce RNase_7 expression via STAT3 in primary keratinocytes .
11470914	0	STAT3	14,19	Rac1	0,4	STAT3	Rac1	6774	5879	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Rac1 mediates STAT3 activation by autocrine IL-6 .
21531053	0	STAT3	61,66	Raf	82,85	STAT3	Raf	6774	22882	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf .
19937797	0	STAT3	26,31	SHP-1	101,106	STAT3	SHP-1	6774	5777	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Betulinic_acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple_myeloma cells .
21818116	0	STAT3	27,32	SHP-1	71,76	STAT3	SHP-1	6774	8431	Gene	Gene	activation|nmod|START_ENTITY independent|nsubj|activation independent|nmod|END_ENTITY	Constitutive activation of STAT3 in S __ zary_syndrome is independent of SHP-1 .
23917203	0	STAT3	27,32	SIPAR	0,5	STAT3	SIPAR	6774	84792	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma .
26026268	0	STAT3	23,28	SIPAR	47,52	STAT3	SIPAR	6774	84792	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Nuclear termination of STAT3 signaling through SIPAR -LRB- STAT3-Interacting_Protein_As_a_Repressor -RRB- - dependent recruitment of T cell tyrosine phosphatase TC-PTP .
27064016	0	STAT3	21,26	SOCS-1	70,76	STAT3	SOCS-1	6774	8651	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|induction induction|nmod|END_ENTITY	Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1 : Role in apoptosis induction and radiosensitization in head_and_neck_tumor cells .
17888401	0	STAT3	55,60	SOCS1	0,5	STAT3	SOCS1	6774	8651	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast_cancer cells .
23817566	0	STAT3	98,103	SOCS1	130,135	STAT3	SOCS1	6774	8651	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of miR-155 affects pancreatic_cancer cell invasiveness and migration by modulating the STAT3 signaling pathway through SOCS1 .
12392283	0	STAT3	74,79	SOCS3	47,52	STAT3	SOCS3	25125(Tax:10116)	89829(Tax:10116)	Gene	Gene	decreases|nmod|START_ENTITY lead|nmod|decreases lead|nsubj|increases increases|nmod|END_ENTITY	Thermal injury-induced increases of hepatocyte SOCS3 lead to decreases in STAT3 .
17028185	0	STAT3	39,44	SOCS3	8,13	STAT3	SOCS3	20848(Tax:10090)	12702(Tax:10090)	Gene	Gene	function|compound|START_ENTITY converts|dobj|function converts|nsubj|Loss Loss|nmod|expression expression|compound|END_ENTITY	Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic .
19524687	0	STAT3	125,130	SOCS3	15,20	STAT3	SOCS3	6774	9021	Gene	Gene	downregulating|nmod|START_ENTITY suppresses|advcl|downregulating suppresses|nsubj|Restoration Restoration|nmod|END_ENTITY	Restoration of SOCS3 suppresses human lung_adenocarcinoma cell growth by downregulating activation of Erk1/2 , Akt apart from STAT3 .
20484656	0	STAT3	59,64	SOCS3	20,25	STAT3	SOCS3	6774	9021	Gene	Gene	IL-6-induced|dep|START_ENTITY phosphorylation|amod|IL-6-induced inhibits|dobj|phosphorylation inhibits|nsubj|expression expression|compound|END_ENTITY	IFN_gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells .
21354254	0	STAT3	34,39	SOCS3	16,21	STAT3	SOCS3	6774	9021	Gene	Gene	phosphorylation|compound|START_ENTITY limiting|dobj|phosphorylation limiting|nsubj|END_ENTITY	Hypoxia-induced SOCS3 is limiting STAT3 phosphorylation and NF-kB activation in congenital_heart_disease .
21617181	0	STAT3	145,150	SOCS3	118,123	STAT3	SOCS3	20848(Tax:10090)	12702(Tax:10090)	Gene	Gene	inhibiting|dobj|START_ENTITY reduces|advcl|inhibiting reduces|dobj|levels levels|nummod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-b / - -LRB- PPAR-b / - -RRB- ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes .
22575502	0	STAT3	127,132	SOCS3	102,107	STAT3	SOCS3	6774	9021	Gene	Gene	activation|compound|START_ENTITY expression|nmod|activation expression|nummod|END_ENTITY	A novel pro-inflammatory mechanism of action of resistin in human endothelial cells : up-regulation of SOCS3 expression through STAT3 activation .
22929979	0	STAT3	58,63	SOCS3	85,90	STAT3	SOCS3	20848(Tax:10090)	12702(Tax:10090)	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|expression expression|nummod|END_ENTITY	Platelet_factor_4 induces cell apoptosis by inhibition of STAT3 via up-regulation of SOCS3 expression in multiple myeloma .
23027374	0	STAT3	41,46	SOCS3	110,115	STAT3	SOCS3	6774	9021	Gene	Gene	activation|compound|START_ENTITY suppresses|dobj|activation suppresses|nmod|induction induction|nmod|END_ENTITY	Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon_carcinoma cells through induction of SOCS3 .
23104276	0	STAT3	44,49	SOCS3	29,34	STAT3	SOCS3	6774	9021	Gene	Gene	START_ENTITY|nsubj|decreases decreases|nmod|increase increase|compound|END_ENTITY	Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression .
23226414	0	STAT3	19,24	SOCS3	101,106	STAT3	SOCS3	6774	9021	Gene	Gene	role|nmod|START_ENTITY role|dep|effect effect|nmod|END_ENTITY	Protective role of STAT3 in NMDA and glutamate-induced neuronal_death : negative regulatory effect of SOCS3 .
23238769	0	STAT3	79,84	SOCS3	46,51	STAT3	SOCS3	20848(Tax:10090)	12702(Tax:10090)	Gene	Gene	signals|compound|START_ENTITY enhance|dobj|signals decreasing|advcl|enhance decreasing|dobj|expression expression|compound|END_ENTITY	A20 promotes liver_regeneration by decreasing SOCS3 expression to enhance IL-6 / STAT3 proliferative signals .
23782265	0	STAT3	165,170	SOCS3	73,78	STAT3	SOCS3	6774	9021	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Flavanoids induce expression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- gene and suppress IL-6-activated signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in vascular endothelial cells .
24491408	0	STAT3	29,34	SOCS3	92,97	STAT3	SOCS3	6774	9021	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	MicroRNA let-7 downregulates STAT3 phosphorylation in pancreatic_cancer cells by increasing SOCS3 expression .
25649351	0	STAT3	77,82	SOCS3	0,5	STAT3	SOCS3	6774	9021	Gene	Gene	Activation|compound|START_ENTITY Involvement|nmod|Activation Development|dep|Involvement Development|compound|END_ENTITY	SOCS3 Deficiency_in_Myeloid_Cells_Promotes_Tumor Development : Involvement of STAT3 Activation and Myeloid-Derived Suppressor Cells .
26707189	0	STAT3	54,59	SOCS3	45,50	STAT3	SOCS3	6774	9021	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Isolinderalactone enhances the inhibition of SOCS3 on STAT3 activity by decreasing miR-30c in breast_cancer .
26847351	0	STAT3	53,58	SOCS3	30,35	STAT3	SOCS3	6774	9021	Gene	Gene	signaling|compound|START_ENTITY promotes|nsubj|signaling repression|parataxis|promotes repression|nmod|END_ENTITY	Transcriptional repression of SOCS3 mediated by IL-6 / STAT3 signaling via DNMT1 promotes pancreatic_cancer growth and metastasis .
25096061	0	STAT3	30,35	SPTBN1	39,45	STAT3	SPTBN1	6774	6711	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2 .
11713584	0	STAT3	29,34	STAT1	44,49	STAT3	STAT1	6774	6772	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	EGFR dependent expression of STAT3 -LRB- but not STAT1 -RRB- in breast_cancer .
18620071	0	STAT3	25,30	STAT1	19,24	STAT3	STAT1	6774	6772	Gene	Gene	seesaw|compound|START_ENTITY END_ENTITY|dep|seesaw	Ups and downs : the STAT1 : STAT3 seesaw of Interferon and gp130 receptor signalling .
19424608	0	STAT3	59,64	STAT1	11,16	STAT3	STAT1	6774	6772	Gene	Gene	inhibition|nummod|START_ENTITY induced|nmod|inhibition effect|acl|induced disturbs|dobj|effect disturbs|nsubj|Absence Absence|nmod|END_ENTITY	Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head_and_neck_carcinoma cell lines .
21723864	0	STAT3	94,99	STAT1	46,51	STAT3	STAT1	6774	6772	Gene	Gene	absence|nmod|START_ENTITY targets|nmod|absence targets|nummod|END_ENTITY	The immediate early genes Fos and Egr1 become STAT1 transcriptional targets in the absence of STAT3 .
22110204	0	STAT3	19,24	STAT1	100,105	STAT3	STAT1	6774	6772	Gene	Gene	Phosphorylation|nmod|START_ENTITY requires|nsubj|Phosphorylation requires|advcl|occurs occurs|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Phosphorylation of STAT3 in head_and_neck_cancer requires p38_MAPKinase , whereas phosphorylation of STAT1 occurs via a different signaling pathway .
22693070	0	STAT3	80,85	STAT1	0,5	STAT3	STAT1	6774	6772	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|expression expression|nummod|END_ENTITY	STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 .
25079358	0	STAT3	84,89	STAT1	11,16	STAT3	STAT1	20848(Tax:10090)	20846(Tax:10090)	Gene	Gene	results|nmod|START_ENTITY results|amod|Absence Absence|nmod|END_ENTITY	Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD .
25364701	0	STAT3	0,5	STAT1	66,71	STAT3	STAT1	6774	6772	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|nmod|END_ENTITY	STAT3 Inhibition Induces Apoptosis in Cancer Cells Independent of STAT1 or STAT2 .
26255980	0	STAT3	40,45	STAT1	17,22	STAT3	STAT1	6774	6772	Gene	Gene	activity|compound|START_ENTITY impair|dobj|activity impair|nsubj|mutations mutations|compound|END_ENTITY	Gain-of-function STAT1 mutations impair STAT3 activity in patients with Chronic_Mucocutaneous_Candidiasis -LRB- CMC -RRB- .
26299368	0	STAT3	110,115	STAT1	0,5	STAT3	STAT1	6774	6772	Gene	Gene	activation|nmod|START_ENTITY signalling|nmod|activation IFN|xcomp|signalling IFN|nsubj|redirects redirects|compound|END_ENTITY	STAT1 deficiency redirects IFN signalling toward suppression of TLR response through a feedback activation of STAT3 .
26673664	0	STAT3	73,78	STAT1	8,13	STAT3	STAT1	20848(Tax:10090)	20846(Tax:10090)	Gene	Gene	Akt|compound|START_ENTITY modulation|nmod|Akt protects|nmod|modulation protects|nsubj|Loss Loss|nmod|END_ENTITY	Loss of STAT1 protects hair cells from ototoxicity through modulation of STAT3 , c-Jun , Akt , and autophagy factors .
26010889	0	STAT3	116,121	STAT3	23,28	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	116,121	STAT3	23,28	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	116,121	STAT3	63,68	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	116,121	STAT3	63,68	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	23,28	STAT3	116,121	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	23,28	STAT3	116,121	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	23,28	STAT3	63,68	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	23,28	STAT3	63,68	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	63,68	STAT3	116,121	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	63,68	STAT3	116,121	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	63,68	STAT3	23,28	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
26010889	0	STAT3	63,68	STAT3	23,28	STAT3	STAT3	6774	6774	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Eriocalyxin_B Inhibits STAT3 Signaling by Covalently Targeting STAT3 and Blocking Phosphorylation and Activation of STAT3 .
24711622	0	STAT3	0,5	STAT4	7,12	STAT3	STAT4	20848(Tax:10090)	20849(Tax:10090)	Gene	Gene	regulate|advmod|START_ENTITY regulate|nsubj|END_ENTITY	STAT3 , STAT4 , NFATc1 , and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells .
17015686	0	STAT3	57,62	STAT5	24,29	STAT3	STAT5	6774	6776	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A preferential role for STAT5 , not constitutively active STAT3 , in promoting survival of a human lymphoid_tumor .
23716595	0	STAT3	18,23	STAT5	0,5	STAT3	STAT5	6774	6776	Gene	Gene	outcompetes|dobj|START_ENTITY outcompetes|nsubj|END_ENTITY	STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6 .
24762632	0	STAT3	0,5	STAT5	53,58	STAT3	STAT5	6774	6776	Gene	Gene	Activity|compound|START_ENTITY Activity|dep|Modulation Modulation|nmod|END_ENTITY	STAT3 Activity and Function in Cancer : Modulation by STAT5 and miR-146b .
26976954	0	STAT3	0,5	STAT5	14,19	STAT3	STAT5	6774	6776	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells .
8977235	0	STAT3	121,126	STAT5	107,112	STAT3	STAT5	6774	6776	Gene	Gene	required|nsubjpass|START_ENTITY required|advcl|signaling signaling|dobj|pathways pathways|acl|induced induced|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|nmod|activation activation|nmod|END_ENTITY	Multiple signaling pathways induced by granulocyte_colony-stimulating_factor involving activation of JAKs , STAT5 , and/or STAT3 are required for regulation of three distinct classes of immediate early genes .
24600488	0	STAT3	40,45	Serine_threonine_kinase_Pim-3	0,29	STAT3	Serine threonine kinase Pim-3	6774	415116	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Serine_threonine_kinase_Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver_cancers .
25561562	0	STAT3	90,95	Signal_Transducer_and_Activator_of_Transcription_3	38,88	STAT3	Signal Transducer and Activator of Transcription 3	6774	6774	Gene	Gene	Pathway|appos|START_ENTITY Pathway|compound|END_ENTITY	Novel Thiosemicarbazones Regulate the Signal_Transducer_and_Activator_of_Transcription_3 -LRB- STAT3 -RRB- Pathway : Inhibition of Constitutive and Interleukin_6 -LRB- IL6 -RRB- - Induced Activation by Iron Depletion .
26228595	0	STAT3	103,108	Signal_Transducer_and_Activator_of_Transcription_3	51,101	STAT3	Signal Transducer and Activator of Transcription 3	6774	6774	Gene	Gene	Pathway|appos|START_ENTITY Pathway|compound|END_ENTITY	Cardiopulmonary Bypass Decreases Activation of the Signal_Transducer_and_Activator_of_Transcription_3 -LRB- STAT3 -RRB- Pathway in Diabetic Human Myocardium .
19875458	0	STAT3	52,57	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	Signal transducer and activator of transcription 3	6774	6774	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- mediates amino_acid inhibition of insulin signaling through serine 727 phosphorylation .
22496368	0	STAT3	52,57	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	Signal transducer and activator of transcription 3	20848(Tax:10090)	20848(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- protein suppresses adenoma-to-carcinoma transition in Apcmin / + mice via regulation of Snail-1 -LRB- SNAI -RRB- protein stability .
23733189	0	STAT3	52,57	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	Signal transducer and activator of transcription 3	20848(Tax:10090)	20848(Tax:10090)	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- degradation by proteasome controls a developmental switch in neurotrophin_dependence .
26942696	0	STAT3	52,57	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	Signal transducer and activator of transcription 3	6774	6774	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- inhibitor , S3I-201 , acts as a potent and non-selective alkylating agent .
26616859	0	STAT3	0,5	Smad3	33,38	STAT3	Smad3	6774	4088	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	STAT3 selectively interacts with Smad3 to antagonize TGF-b .
18843197	0	STAT3	104,109	Socs1	69,74	STAT3	Socs1	25125(Tax:10116)	252971(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY associated|nmod|activation associated|nsubjpass|downregulation downregulation|nmod|gene gene|appos|END_ENTITY	Epigenetic downregulation of the suppressor_of_cytokine_signaling_1 -LRB- Socs1 -RRB- gene is associated with the STAT3 activation and development of hepatocellular_carcinoma induced by methyl-deficiency in rats .
10688651	0	STAT3	86,91	Src	79,82	STAT3	Src	20848(Tax:10090)	20779(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY linking|nmod|activation linking|dobj|END_ENTITY	Etk , a Btk family tyrosine kinase , mediates cellular transformation by linking Src to STAT3 activation .
11114718	0	STAT3	114,119	Src	58,61	STAT3	Src	20848(Tax:10090)	20779(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY role|nmod|signaling Induction|dep|role Induction|nmod|oncoprotein oncoprotein|compound|END_ENTITY	Induction of p21WAF1/CIP1 and cyclin_D1 expression by the Src oncoprotein in mouse fibroblasts : role of activated STAT3 signaling .
12244095	0	STAT3	14,19	Src	27,30	STAT3	Src	25125(Tax:10116)	83805(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Hck Hck|compound|END_ENTITY	Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain .
17575268	0	STAT3	24,29	Src	86,89	STAT3	Src	6774	6714	Gene	Gene	START_ENTITY|acl:relcl|kinases kinases|nsubj|factors factors|nmod|family family|nmod|END_ENTITY	Acute alcohol activates STAT3 , AP-1 , and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes .
19223541	0	STAT3	88,93	Src	10,13	STAT3	Src	6774	6714	Gene	Gene	activation|appos|START_ENTITY results|nmod|activation inhibition|dobj|results inhibition|nsubj|END_ENTITY	Sustained Src inhibition results in signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding .
20881478	0	STAT3	76,81	Src	56,59	STAT3	Src	6774	6714	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation .
25425624	0	STAT3	0,5	Synaptopodin	43,55	STAT3	Synaptopodin	20848(Tax:10090)	104027(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	STAT3 Regulates Steady-State Expression of Synaptopodin in Cultured Mouse Podocytes .
11960349	0	STAT3	31,36	TGF-beta1	65,74	STAT3	TGF-beta1	6774	7040	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and - independent processes .
11418694	0	STAT3	72,77	TGF_beta	105,113	STAT3	TGF beta	6774	7040	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF_beta is reversed by IL-15 .
21711826	0	STAT3	162,167	TIMP-1	171,177	STAT3	TIMP-1	20848(Tax:10090)	21857(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Tissue_inhibitor_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- deficiency exacerbates carbon_tetrachloride-induced liver_injury and fibrosis in mice : involvement of hepatocyte STAT3 in TIMP-1 production .
21711826	0	STAT3	162,167	TIMP-1	41,47	STAT3	TIMP-1	20848(Tax:10090)	21857(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY exacerbates|parataxis|involvement exacerbates|nsubj|deficiency deficiency|appos|END_ENTITY	Tissue_inhibitor_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- deficiency exacerbates carbon_tetrachloride-induced liver_injury and fibrosis in mice : involvement of hepatocyte STAT3 in TIMP-1 production .
21293887	0	STAT3	44,49	TLR-4	18,23	STAT3	TLR-4	6774	7099	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle .
21151968	0	STAT3	42,47	TLR4	0,4	STAT3	TLR4	25125(Tax:10116)	29260(Tax:10116)	Gene	Gene	activation|advmod|START_ENTITY cell|amod|activation inhibits|dobj|cell inhibits|nsubj|END_ENTITY	TLR4 inhibits mesenchymal stem cell -LRB- MSC -RRB- STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection .
25595264	0	STAT3	68,73	TLR4	11,15	STAT3	TLR4	20848(Tax:10090)	21898(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain .
26299839	0	STAT3	113,118	TLR4	23,27	STAT3	TLR4	20848(Tax:10090)	21898(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY mediated|ccomp|dependent mediated|nsubj|END_ENTITY	Angiotensin_II-induced TLR4 mediated abdominal_aortic_aneurysm in apolipoprotein_E knockout mice is dependent on STAT3 .
26582088	0	STAT3	41,46	TLR4	0,4	STAT3	TLR4	20848(Tax:10090)	21898(Tax:10090)	Gene	Gene	Cooperates|nmod|START_ENTITY Signaling|nmod|Cooperates Signaling|compound|END_ENTITY	TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice .
22194466	0	STAT3	95,100	TNF-a	56,61	STAT3	TNF-a	6774	7124	Gene	Gene	signaling|compound|START_ENTITY escape|nmod|signaling escape|dobj|effects effects|nmod|END_ENTITY	Metastatic cells can escape the proapoptotic effects of TNF-a through increased autocrine IL-6 / STAT3 signaling .
22506067	0	STAT3	0,5	TNF-alpha	25,34	STAT3	TNF-alpha	6774	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass .
20516148	0	STAT3	16,21	TRIM8	0,5	STAT3	TRIM8	20848(Tax:10090)	93679(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	TRIM8 modulates STAT3 activity through negative regulation of PIAS3 .
22468949	0	STAT3	95,100	TRa1	119,123	STAT3	TRa1	20848(Tax:10090)	22027(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Thyroid hormone promotes neuronal differentiation of embryonic neural stem cells by inhibiting STAT3 signaling through TRa1 .
25871878	0	STAT3	41,46	Th2	19,22	STAT3	Th2	20848(Tax:10090)	15111(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Dynamic control of Th2 cell responses by STAT3 during allergic_lung_inflammation in mice .
25871878	0	STAT3	41,46	Th2	19,22	STAT3	Th2	20848(Tax:10090)	15111(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Dynamic control of Th2 cell responses by STAT3 during allergic_lung_inflammation in mice .
24708416	0	STAT3	72,77	Toll-like_receptor_3	43,63	STAT3	Toll-like receptor 3	6774	7098	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Interleukin-17 increases the expression of Toll-like_receptor_3 via the STAT3 pathway in rheumatoid_arthritis fibroblast-like synoviocytes .
16611639	0	STAT3	0,5	Trk	34,37	STAT3	Trk	25125(Tax:10116)	59109(Tax:10116)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	STAT3 as a downstream mediator of Trk signaling and functions .
22750444	0	STAT3	0,5	USP7	16,20	STAT3	IL-6	6774	3569	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	STAT3 repressed USP7 expression is crucial for colon_cancer development .
12824281	0	STAT3	30,35	VEGF	0,4	STAT3	VEGF	6774	7422	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	VEGF differentially activates STAT3 in microvascular endothelial cells .
15688401	0	STAT3	206,211	VEGF	130,134	STAT3	VEGF	20848(Tax:10090)	22339(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY cells|nmod|interaction regulates|nmod|cells regulates|dobj|activity activity|amod|END_ENTITY	Interleukin-6 induces transcriptional activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1 .
15919761	0	STAT3	0,5	VEGF	49,53	STAT3	VEGF	6774	7422	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|expression expression|amod|END_ENTITY	STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal_carcinoma cells .
16257644	0	STAT3	74,79	VEGF	24,28	STAT3	VEGF	6774	7422	Gene	Gene	cells|nmod|START_ENTITY increases|nmod|cells increases|dobj|expression expression|amod|END_ENTITY	Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3 .
17009627	0	STAT3	32,37	VEGF	0,4	STAT3	VEGF	6774	7422	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian_carcinoma cells in vitro .
17509611	0	STAT3	0,5	VEGF	49,53	STAT3	VEGF	20848(Tax:10090)	22339(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|ccomp|stem stem|dobj|production production|compound|END_ENTITY	STAT3 mediates bone marrow mesenchymal stem cell VEGF production .
18981713	0	STAT3	10,15	VEGF	47,51	STAT3	VEGF	20848(Tax:10090)	22339(Tax:10090)	Gene	Gene	mediator|nsubj|START_ENTITY mediator|nmod|activation activation|compound|END_ENTITY	Activated STAT3 is a mediator and biomarker of VEGF endothelial activation .
20204302	0	STAT3	68,73	VEGF	33,37	STAT3	VEGF	6774	7422	Gene	Gene	suppression|nmod|START_ENTITY production|nmod|suppression production|amod|END_ENTITY	Dexamethasone treatment inhibits VEGF production via suppression of STAT3 in a head_and_neck_cancer cell line .
23104276	0	STAT3	44,49	VEGF	76,80	STAT3	VEGF	6774	7422	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression .
17009627	0	STAT3	32,37	VEGFR2	54,60	STAT3	VEGFR2	6774	3791	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nmod|END_ENTITY	VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian_carcinoma cells in vitro .
19751774	0	STAT3	17,22	Visfatin	0,8	STAT3	Visfatin	6774	10135	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis .
15845352	0	STAT3	53,58	Zfp-57	18,24	STAT3	Zfp-57	6774	346171	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3 / 4 in embryonic stem cells .
8662591	0	STAT3	55,60	acute_phase_response_factor	27,54	STAT3	acute phase response factor	6774	6774	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Differential activation of acute_phase_response_factor / STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130 .
12812653	0	STAT3	82,87	angiotensin_II	64,78	STAT3	angiotensin II	6774	183	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Changes of STAT3 in cell replicative senescence and effects of angiotensin_II on STAT3 -RSB- .
20830236	0	STAT3	0,5	b-catenin	73,82	STAT3	b-catenin	6774	1499	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	STAT3 upregulates the protein expression and transcriptional activity of b-catenin in breast_cancer .
25348333	0	STAT3	0,5	b-catenin	31,40	STAT3	b-catenin	6774	1499	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	STAT3 paradoxically stimulates b-catenin expression but inhibits b-catenin function .
8900046	0	STAT3	33,38	bFGF	0,4	STAT3	bFGF	6774	2247	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	bFGF and LIF signaling activates STAT3 in proliferating myoblasts .
16568091	0	STAT3	18,23	breast_tumor_kinase	51,70	STAT3	breast tumor kinase	6774	5753	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|substrate substrate|nmod|END_ENTITY	Identification of STAT3 as a specific substrate of breast_tumor_kinase .
22547065	0	STAT3	78,83	breast_tumor_kinase	44,63	STAT3	breast tumor kinase	6774	5753	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Suppressor_of_cytokine_signaling_3 inhibits breast_tumor_kinase activation of STAT3 .
11356008	0	STAT3	31,36	c-Jun	0,5	STAT3	c-Jun	6774	3725	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element -LRB- IRE -RRB- .
18779368	0	STAT3	81,86	c-Met	71,76	STAT3	c-Met	6774	4233	Gene	Gene	accumulation|compound|START_ENTITY END_ENTITY|nmod|accumulation	Receptor trafficking controls weak signal delivery : a strategy used by c-Met for STAT3 nuclear accumulation .
12235142	0	STAT3	16,21	caveolin-1	27,37	STAT3	caveolin-1	6774	857	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of STAT3 with caveolin-1 and heat_shock_protein_90 in plasma membrane raft and cytosolic complexes .
16205632	0	STAT3	15,20	epidermal_growth_factor	79,102	STAT3	epidermal growth factor	6774	1950	Gene	Gene	Requirement|nmod|START_ENTITY activation|nsubj|Requirement activation|nmod|characteristics characteristics|amod|END_ENTITY	Requirement of STAT3 activation for maximal collagenase-1 -LRB- MMP-1 -RRB- induction by epidermal_growth_factor and malignant characteristics in T24 bladder_cancer cells .
25175149	0	STAT3	117,122	epidermal_growth_factor	40,63	STAT3	epidermal growth factor	6774	1950	Gene	Gene	inhibition|nmod|START_ENTITY suppressed|nmod|inhibition suppressed|nsubjpass|Induction Induction|nmod|fibronectin fibronectin|nmod|response response|nmod|END_ENTITY	Induction of fibronectin in response to epidermal_growth_factor is suppressed by silibinin through the inhibition of STAT3 in triple negative breast_cancer cells .
22230249	0	STAT3	14,19	erythropoietin	89,103	STAT3	erythropoietin	25125(Tax:10116)	24335(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY inhibits|nsubj|activation inhibits|nmod|expression expression|compound|END_ENTITY	VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression .
10661409	0	STAT3	77,82	gp130	41,46	STAT3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	signals|amod|START_ENTITY roles|nmod|signals Dissection|dep|roles Dissection|acl|signaling signaling|nmod|END_ENTITY	Dissection of signaling cascades through gp130 in vivo : reciprocal roles for STAT3 - and SHP2-mediated signals in immune responses .
12782602	0	STAT3	72,77	gp130	191,196	STAT3	gp130	6774	3572	Gene	Gene	activation|nmod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|stimulation stimulation|nmod|system system|amod|END_ENTITY	Epidermal_growth_factor_receptor-independent constitutive activation of STAT3 in head_and_neck_squamous_cell_carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin_6 / gp130 cytokine system .
15927449	0	STAT3	38,43	gp130	101,106	STAT3	gp130	6774	3572	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|motifs motifs|nmod|END_ENTITY	Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130 .
16624864	0	STAT3	51,56	gp130	23,28	STAT3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY constitutive|dobj|activation leads|xcomp|constitutive leads|nsubj|dimerization dimerization|nmod|END_ENTITY	Forced dimerization of gp130 leads to constitutive STAT3 activation , cytokine-independent growth , and blockade of differentiation of embryonic stem cells .
18431520	0	STAT3	0,5	gp130	93,98	STAT3	gp130	20848(Tax:10090)	16157(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|gastric_tumorigenesis gastric_tumorigenesis|nmod|mice mice|nummod|END_ENTITY	STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric_tumorigenesis in gp130 receptor mutant mice .
19285962	0	STAT3	28,33	gp130	69,74	STAT3	gp130	6774	3572	Gene	Gene	pathway|compound|START_ENTITY inhibits|dobj|pathway inhibits|advcl|depleting depleting|dobj|pools pools|amod|END_ENTITY	Capsaicin inhibits the IL-6 / STAT3 pathway by depleting intracellular gp130 pools through endoplasmic_reticulum_stress .
19885008	0	STAT3	44,49	gp130	106,111	STAT3	gp130	6774	3572	Gene	Gene	Pathway|compound|START_ENTITY Pathway|dep|Translation Translation|nmod|END_ENTITY	Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130 .
19967068	0	STAT3	92,97	gp130	85,90	STAT3	gp130	6774	3572	Gene	Gene	Signaling|compound|START_ENTITY Signaling|amod|END_ENTITY	Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130 / STAT3 Signaling .
25253866	0	STAT3	103,108	gp130	170,175	STAT3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130 .
25481644	0	STAT3	51,56	gp130	86,91	STAT3	gp130	6774	3572	Gene	Gene	phosphorylation|compound|START_ENTITY contributes|nmod|phosphorylation contributes|nmod|transactivation transactivation|amod|END_ENTITY	Sphingosine_kinase_1 contributes to leptin-induced STAT3 phosphorylation through IL-6 / gp130 transactivation in oestrogen receptor-negative breast_cancer .
26848037	0	STAT3	84,89	gp130	8,13	STAT3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY colitis|nmod|activation ameliorates|dobj|colitis ameliorates|nsubj|signalling signalling|amod|END_ENTITY	Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells .
7624343	0	STAT3	0,5	gp130	40,45	STAT3	gp130	6774	3572	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase .
8934572	0	STAT3	102,107	gp130	80,85	STAT3	gp130	6774	4827	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Two signals are necessary for cell proliferation induced by a cytokine receptor gp130 : involvement of STAT3 in anti-apoptosis .
9711940	0	STAT3	56,61	gp130	14,19	STAT3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY transduces|dobj|signals transduces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes .
26952843	0	STAT3	144,149	high_mobility_group_A1	113,135	STAT3	high mobility group A1	6774	3159	Gene	Gene	pathway|nummod|START_ENTITY END_ENTITY|dep|pathway	STAT3 inhibitor has potent antitumor activity in B-lineage acute_lymphoblastic_leukemia cells overexpressing the high_mobility_group_A1 -LRB- HMGA1 -RRB- - STAT3 pathway .
10747872	0	STAT3	13,18	insulin-like_growth_factor_I_receptor	33,70	STAT3	insulin-like growth factor I receptor	6774	3480	Gene	Gene	Mechanism|nmod|START_ENTITY activation|nsubj|Mechanism activation|nmod|END_ENTITY	Mechanism of STAT3 activation by insulin-like_growth_factor_I_receptor .
10080544	0	STAT3	31,36	interferon-gamma	40,56	STAT3	interferon-gamma	6774	3458	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils .
11141475	0	STAT3	68,73	interleukin-11	28,42	STAT3	interleukin-11	6774	3589	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate_carcinoma .
12239166	0	STAT3	59,64	interleukin-11	34,48	STAT3	interleukin-11	20848(Tax:10090)	16156(Tax:10090)	Gene	Gene	induce|dobj|START_ENTITY END_ENTITY|xcomp|induce	Heparin acts synergistically with interleukin-11 to induce STAT3 activation and in vitro osteoclast formation .
24036113	0	STAT3	123,128	interleukin-11	81,95	STAT3	interleukin-11	6774	3589	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Bovine lactoferricin-induced anti-inflammation is , in part , via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage .
22922995	0	STAT3	0,5	interleukin-22	34,48	STAT3	interleukin-22	6774	50616	Gene	Gene	signal|nsubj|START_ENTITY signal|nmod|END_ENTITY	STAT3 signal transduction through interleukin-22 in oral_squamous_cell_carcinoma .
23674871	0	STAT3	29,34	interleukin-22	14,28	STAT3	interleukin-22	6774	50616	Gene	Gene	signaling|nsubj|START_ENTITY Expression|parataxis|signaling Expression|nmod|END_ENTITY	Expression of interleukin-22 / STAT3 signaling pathway in ulcerative_colitis and related carcinogenesis .
12037677	0	STAT3	0,5	interleukin-6	33,46	STAT3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nsubjpass|activation required|nmod|transformation transformation|amod|END_ENTITY	STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells .
16926159	0	STAT3	78,83	interleukin-6	37,50	STAT3	interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY signaling|nmod|activation inhibits|xcomp|signaling inhibits|xcomp|END_ENTITY	Pyrrolidine_dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes .
16939807	0	STAT3	76,81	interleukin-6	58,71	STAT3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Delta-4 expression on a stromal cell line is augmented by interleukin-6 via STAT3 activation .
17875759	0	STAT3	32,37	interleukin-6	18,31	STAT3	interleukin-6	6774	3569	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Activation of the interleukin-6 / STAT3 antiapoptotic pathway in esophageal cells by bile_acids and low pH : relevance to barrett 's _ esophagus .
19071214	0	STAT3	41,46	interleukin-6	71,84	STAT3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|nmod|expression expression|amod|END_ENTITY	Hepatocyte_growth_factor induces delayed STAT3 phosphorylation through interleukin-6 expression .
19330073	0	STAT3	117,122	interleukin-6	137,150	STAT3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	signal_transduction_and_activation_of_transcription_3|appos|START_ENTITY signal_transduction_and_activation_of_transcription_3|acl|attenuate attenuate|dobj|action action|amod|END_ENTITY	Pravastatin prevents aortic_atherosclerosis via modulation of signal_transduction_and_activation_of_transcription_3 -LRB- STAT3 -RRB- to attenuate interleukin-6 -LRB- IL-6 -RRB- action in ApoE knockout mice .
22157761	0	STAT3	66,71	interleukin-6	84,97	STAT3	interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_3|appos|START_ENTITY signal_transducer_and_activator_of_transcription_3|amod|END_ENTITY	Inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- attenuates interleukin-6 -LRB- IL-6 -RRB- - induced collagen synthesis and resultant hypertrophy in rat heart .
22522122	0	STAT3	78,83	interleukin-6	64,77	STAT3	interleukin-6	6774	3569	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6 / STAT3 pathway .
23903834	0	STAT3	83,88	interleukin-6	43,56	STAT3	interleukin-6	6774	3569	Gene	Gene	signaling|nmod|START_ENTITY signaling|dep|END_ENTITY	Human_cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus .
23917204	0	STAT3	73,78	interleukin-6	26,39	STAT3	interleukin-6	6774	3569	Gene	Gene	pathway|compound|START_ENTITY downregulation|nmod|pathway expression|nmod|downregulation expression|amod|END_ENTITY	TIS21 -LRB- / BTG2/PC3 -RRB- inhibits interleukin-6 expression via downregulation of STAT3 pathway .
24912675	0	STAT3	74,79	interleukin-6	60,73	STAT3	interleukin-6	6774	3569	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	Cross talk between the TM4SF5/focal _ adhesion_kinase and the interleukin-6 / STAT3 pathways promotes immune escape of human liver_cancer cells .
25636517	0	STAT3	4,9	interleukin-6	134,147	STAT3	interleukin-6	6774	3569	Gene	Gene	WP1066|compound|START_ENTITY reverses|nsubj|WP1066 reverses|xcomp|histone histone|dobj|inhibitors inhibitors|acl|induced induced|advcl|END_ENTITY	The STAT3 inhibitor WP1066 reverses the resistance of chronic_lymphocytic_leukemia cells to histone deacetylase inhibitors induced by interleukin-6 .
25938734	0	STAT3	71,76	interleukin-6	105,118	STAT3	interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Toll-like_receptor_4-mediated immune stress in pregnant rats activates STAT3 in the fetal brain : role of interleukin-6 .
26527061	0	STAT3	73,78	interleukin-6	41,54	STAT3	interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|synthesis synthesis|amod|END_ENTITY	cAMP/PKA enhances interleukin-1b-induced interleukin-6 synthesis through STAT3 in glial cells .
8621622	0	STAT3	0,5	interleukin-6	83,96	STAT3	interleukin-6	6774	3569	Gene	Gene	participates|nsubj|START_ENTITY participates|advcl|END_ENTITY	STAT3 participates in transcriptional activation of the C-reactive_protein gene by interleukin-6 .
9311994	0	STAT3	37,42	interleukin-6	88,101	STAT3	interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	outgrowth|nmod|START_ENTITY control|nmod|outgrowth kinase|nsubj|control kinase|nmod|cells cells|acl|stimulated stimulated|advcl|END_ENTITY	Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6 .
12782602	0	STAT3	72,77	interleukin_6	177,190	STAT3	interleukin 6	6774	3569	Gene	Gene	activation|nmod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|stimulation stimulation|nmod|system system|amod|END_ENTITY	Epidermal_growth_factor_receptor-independent constitutive activation of STAT3 in head_and_neck_squamous_cell_carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin_6 / gp130 cytokine system .
12049654	0	STAT3	114,119	leptin	72,78	STAT3	leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	phosphorylation|nummod|START_ENTITY regulating|dobj|phosphorylation role|acl|regulating regulation|dep|role regulation|nmod|kinase kinase|nmod|END_ENTITY	Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages : role in regulating STAT3 Ser727 phosphorylation and DNA binding .
16814732	0	STAT3	17,22	leptin	26,32	STAT3	leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|actions actions|nmod:poss|END_ENTITY	Critical role of STAT3 in leptin 's metabolic actions .
19049975	0	STAT3	87,92	leptin	15,21	STAT3	leptin	6774	3952	Gene	Gene	interaction|compound|START_ENTITY blocking|dobj|interaction inhibits|advcl|blocking inhibits|dobj|regulation regulation|compound|END_ENTITY	FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity_protein_1 .
22158477	0	STAT3	84,89	leptin	19,25	STAT3	leptin	25125(Tax:10116)	25608(Tax:10116)	Gene	Gene	phosphorylation|nummod|START_ENTITY effects|nmod|phosphorylation Neuroprotection|dep|effects Neuroprotection|nmod|END_ENTITY	Neuroprotection by leptin in a rat model of permanent cerebral_ischemia : effects on STAT3 phosphorylation in discrete cells of the brain .
23462572	0	STAT3	66,71	leptin	23,29	STAT3	leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY effects|nmod|pathway effects|nmod|END_ENTITY	Detrimental effects of leptin on intracerebral_hemorrhage via the STAT3 signal pathway .
25576055	0	STAT3	28,33	leptin	81,87	STAT3	leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	acetylation|compound|START_ENTITY Enhancement|nmod|acetylation dictates|nsubj|Enhancement dictates|dobj|sensitivity sensitivity|compound|END_ENTITY	Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity .
10080923	0	STAT3	28,33	leptin_receptor	52,67	STAT3	leptin receptor	20848(Tax:10090)	16847(Tax:10090)	Gene	Gene	START_ENTITY|nmod|leptin leptin|nmod|END_ENTITY	Tyrosine phosphorylation of STAT3 by leptin through leptin_receptor in mouse metaphase 2 stage oocyte .
17095713	0	STAT3	132,137	leptin_receptor	116,131	STAT3	leptin receptor	20848(Tax:10090)	16847(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Leptin regulates neointima formation after arterial_injury through mechanisms independent of blood pressure and the leptin_receptor / STAT3 signaling pathways involved in energy balance .
17202473	0	STAT3	107,112	leptin_receptor	91,106	STAT3	leptin receptor	20848(Tax:10090)	16847(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY inhibition|parataxis|signaling inhibition|nmod|END_ENTITY	Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin_receptor / STAT3 signaling .
21267512	0	STAT3	52,57	leptin_receptor_long_isoform	15,43	STAT3	leptin receptor long isoform	20848(Tax:10090)	16847(Tax:10090)	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of leptin_receptor_long_isoform -LRB- LepRb -RRB- - STAT3 signaling pathway in brain fat mass - and obesity-associated -LRB- FTO -RRB- downregulation during energy restriction .
10196143	0	STAT3	18,23	leukemia_inhibitory_factor	72,98	STAT3	leukemia inhibitory factor	20848(Tax:10090)	16878(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	Critical role for STAT3 in murine pituitary adrenocorticotropin hormone leukemia_inhibitory_factor signaling .
17608645	0	STAT3	25,30	leukemia_inhibitory_factor	34,60	STAT3	leukemia inhibitory factor	6774	3976	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Retrograde activation of STAT3 by leukemia_inhibitory_factor in sympathetic neurons .
18088375	0	STAT3	0,5	leukemia_inhibitory_factor	38,64	STAT3	leukemia inhibitory factor	20848(Tax:10090)	16878(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|photoreceptors photoreceptors|nmod|END_ENTITY	STAT3 activation in photoreceptors by leukemia_inhibitory_factor is associated with protection from light damage .
21305673	0	STAT3	127,132	leukemia_inhibitory_factor	100,126	STAT3	leukemia inhibitory factor	20848(Tax:10090)	16878(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|dep|END_ENTITY	LacdiNAc -LRB- GalNAcb1-4GlcNAc -RRB- contributes to self-renewal of mouse embryonic stem cells by regulating leukemia_inhibitory_factor / STAT3 signaling .
25607648	0	STAT3	34,39	miR-146a	0,8	STAT3	miR-146a	6774	406938	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	miR-146a is directly regulated by STAT3 in human hepatocellular_carcinoma cells and involved in anti-tumor immune suppression .
24473196	0	STAT3	0,5	miR-146b	19,27	STAT3	miR-146b	6774	574447	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-kB to IL-6 signaling axis and STAT3-driven cancer phenotypes .
10445852	0	STAT3	94,99	p38	32,35	STAT3	p38	6774	1432	Gene	Gene	activation|nmod|START_ENTITY induced|dobj|activation IL-6|acl|induced involved|nmod|IL-6 involved|nsubjpass|END_ENTITY	Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3 .
18941194	0	STAT3	121,126	p53	148,151	STAT3	p53	6774	7157	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	IL-24 induces apoptosis of chronic_lymphocytic_leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression .
18230613	0	STAT3	32,37	profilin-1	76,86	STAT3	profilin-1	25125(Tax:10116)	64303(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1 .
22431190	0	STAT3	101,106	prohibitin	86,96	STAT3	prohibitin	25125(Tax:10116)	25344(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Interleukin_6 protects H -LRB- 2 -RRB- O -LRB- 2 -RRB- - induced cardiomyocytes_injury through upregulation of prohibitin via STAT3 phosphorylation .
16236134	0	STAT3	18,23	serum_amyloid_A	62,77	STAT3	serum amyloid A	6774	6287	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum_amyloid_A gene expression .
18413761	0	STAT3	130,135	signal_transducer_and_activator_of_transcription-3	78,128	STAT3	signal transducer and activator of transcription-3	6774	6774	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Triterpenoid_CDDO-methyl_ester inhibits the Janus-activated kinase-1 -LRB- JAK1 -RRB- -- > signal_transducer_and_activator_of_transcription-3 -LRB- STAT3 -RRB- pathway by direct inhibition of JAK1 and STAT3 .
12894500	0	STAT3	64,69	signal_transducer_and_activator_of_transcription_3	12,62	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in gastrointestinal_stromal_tumors .
16705451	0	STAT3	60,65	signal_transducer_and_activator_of_transcription_3	8,58	STAT3	signal transducer and activator of transcription 3	20848(Tax:10090)	20848(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in stretch_injury to bladder smooth muscle cells .
19223541	0	STAT3	88,93	signal_transducer_and_activator_of_transcription_3	36,86	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Sustained Src inhibition results in signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding .
20149460	0	STAT3	76,81	signal_transducer_and_activator_of_transcription_3	24,74	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- gene , in hyper-IgE_syndrome .
20693278	0	STAT3	105,110	signal_transducer_and_activator_of_transcription_3	53,103	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Microtubule-targeted chemotherapeutic agents inhibit signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- signaling .
21107604	0	STAT3	157,162	signal_transducer_and_activator_of_transcription_3	105,155	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Destructive pulmonary_staphylococcal_infection in a boy with hyper-IgE_syndrome : a novel mutation in the signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- gene -LRB- p.Y657S -RRB- .
22179221	0	STAT3	150,155	signal_transducer_and_activator_of_transcription_3	98,148	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	The peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- b / agonist GW501516 inhibits IL-6-induced signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation and insulin resistance in human liver cells .
24124070	0	STAT3	81,86	signal_transducer_and_activator_of_transcription_3	29,79	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	down-regulation|appos|START_ENTITY down-regulation|nmod|END_ENTITY	Effective down-regulation of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast_tumor cells to conventional chemotherapy .
24167124	0	STAT3	81,86	signal_transducer_and_activator_of_transcription_3	29,79	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	down-regulation|appos|START_ENTITY down-regulation|nmod|END_ENTITY	Effective down-regulation of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast_tumor cells to conventional chemotherapy .
24658061	0	STAT3	95,100	signal_transducer_and_activator_of_transcription_3	43,93	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Raf_kinase_inhibitor_protein -LRB- RKIP -RRB- blocks signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in breast_and_prostate_cancer .
25555814	0	STAT3	72,77	signal_transducer_and_activator_of_transcription_3	20,70	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of fish signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in nodavirus_infection_induced_cell_death .
26500281	0	STAT3	137,142	signal_transducer_and_activator_of_transcription_3	85,135	STAT3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- signalling in HER2-overexpressing BT-474 breast_cancer cells .
21577321	0	STAT3	74,79	signal_transducers_and_activators_of_transcription_3	20,72	STAT3	signal transducers and activators of transcription 3	6774	6774	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Upregulation of the signal_transducers_and_activators_of_transcription_3 -LRB- STAT3 -RRB- pathway in lymphatic metastases of papillary thyroid_cancer .
23166328	0	STAT3	114,119	signal_transducers_and_activators_of_transcription_3	60,112	STAT3	signal transducers and activators of transcription 3	6774	6774	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Cytokine response is determined by duration of receptor and signal_transducers_and_activators_of_transcription_3 -LRB- STAT3 -RRB- activation .
23782265	0	STAT3	165,170	suppressor_of_cytokine_signalling_3	36,71	STAT3	suppressor of cytokine signalling 3	6774	9021	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Flavanoids induce expression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- gene and suppress IL-6-activated signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in vascular endothelial cells .
11788590	0	STAT3	64,69	surfactant_protein_B	35,55	STAT3	surfactant protein B	6774	6439	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional stimulation of the surfactant_protein_B gene by STAT3 in respiratory epithelial cells .
24135280	0	STAT3/5	51,58	EGFR	0,4	STAT3/5	EGFR	6774;6776	1956	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma .
19644876	0	STAT4	15,20	BANK1	38,43	STAT4	BANK1	6775	55024	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of STAT4 and BLK , but not BANK1 or IRF5 , with primary_antiphospholipid_syndrome .
26123499	0	STAT4	0,5	GM-CSF	15,21	STAT4	GM-CSF	20849(Tax:10090)	12981(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|amod|END_ENTITY	STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE .
11466347	0	STAT4	28,33	IFN-gamma	49,58	STAT4	IFN-gamma	6775	3458	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|END_ENTITY	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex .
11466347	0	STAT4	28,33	IL-18	120,125	STAT4	IL-18	6775	3606	Gene	Gene	requirement|nmod|START_ENTITY requirement|nmod|factor factor|nmod|induction induction|nmod|complex complex|amod|END_ENTITY	An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex .
9886399	0	STAT4	13,18	IL-2	0,4	STAT4	IL-2	6775	3558	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	IL-2 induces STAT4 activation in primary NK cells and NK cell lines , but not in T cells .
16081070	0	STAT4	0,5	Ikaros	72,78	STAT4	Ikaros	6775	10320	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells .
24711622	0	STAT4	7,12	STAT3	0,5	STAT4	STAT3	20849(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|advmod|END_ENTITY	STAT3 , STAT4 , NFATc1 , and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells .
26123499	0	STAT4	0,5	Th1	41,44	STAT4	Th1	20849(Tax:10090)	57314(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE .
10491012	0	STAT4	182,187	beta_2	141,147	STAT4	beta 2	6775	10383	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Depressed IL-12-mediated signal transduction in T cells from patients with S __ zary_syndrome is associated with the absence of IL-12 receptor beta_2 mRNA and highly reduced levels of STAT4 .
10820390	0	STAT4	28,33	phosphatidylinositol_3-kinase	38,67	STAT4	phosphatidylinositol 3-kinase	6775	5293	Gene	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	IL-12 selectively regulates STAT4 via phosphatidylinositol_3-kinase and Ras-independent signal transduction pathways .
16819511	0	STAT5	0,5	BCL6	16,20	STAT5	BCL6	6776	604	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas .
11699409	0	STAT5	105,110	BCR-ABL	0,7	STAT5	BCR-ABL	6776	25	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing inhibit|nmod|cells fails|xcomp|inhibit fails|nsubj|END_ENTITY	BCR-ABL fails to inhibit apoptosis in U937 myelomonocytic cells expressing a carboxyl-terminal truncated STAT5 .
8710363	0	STAT5	27,32	BCR-ABL	40,47	STAT5	BCR-ABL	6776	25	Gene	Gene	activation|nmod|START_ENTITY Constitutive|dobj|activation Constitutive|nmod|oncogene oncogene|amod|END_ENTITY	Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic_myelogenous_leukemia .
10419904	0	STAT5	0,5	BCR-Abl	20,27	STAT5	BCR-Abl	6776	25	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells .
11593388	0	STAT5	37,42	BCR/ABL	64,71	STAT5	BCR/ABL	6776	25;613	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells .
12411494	0	STAT5	45,50	BCR/ABL	34,41	STAT5	BCR/ABL	6776	25;613	Gene	Gene	activation|nummod|START_ENTITY END_ENTITY|nmod|activation	The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid_leukemia cells .
10435632	0	STAT5	55,60	Bcl-xL	29,35	STAT5	Bcl-xL	20850(Tax:10090)	12048(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line .
24608043	0	STAT5	120,125	C9orf140	8,16	STAT5	C9orf140	6776	89958	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of C9orf140 in the promotion of colorectal_cancer progression and mechanisms of its upregulation via activation of STAT5 , b-catenin and EZH2 .
24500400	0	STAT5	57,62	CD154	15,20	STAT5	CD154	6776	959	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
24500400	0	STAT5	57,62	CD154	78,83	STAT5	CD154	6776	959	Gene	Gene	expression|nmod|START_ENTITY binding|nsubj|expression binding|nmod|promoter promoter|compound|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
15528362	0	STAT5	17,22	CD2	26,29	STAT5	CD2	6776	914	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|compound|END_ENTITY	Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression .
12384143	0	STAT5	200,205	CD34	139,143	STAT5	CD34	6776	947	Gene	Gene	phosphorylation|nmod|START_ENTITY cells|nmod|phosphorylation cells|compound|END_ENTITY	Transforming_growth_factor-beta -LRB- 1 -RRB- augments granulocyte-macrophage_colony-stimulating_factor-induced proliferation of umbilical cord blood CD34 -LRB- + -RRB- cells with an associated tyrosine phosphorylation of STAT5 .
22993203	0	STAT5	32,37	CD4	75,78	STAT5	CD4	20850(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY activating|dobj|production activating|nmod|T T|compound|END_ENTITY	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
24500400	0	STAT5	57,62	CD4	41,44	STAT5	CD4	6776	920	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter .
22093990	0	STAT5	1,6	CD59	87,91	STAT5	CD59	6776	966	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	-LSB- STAT5 phosphorylation levels of erythropoietin and thrombopoietin_receptors in CD34 -LRB- + -RRB- CD59 -LRB- - -RRB- and CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- bone marrow cells of patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
11245630	0	STAT5	76,81	CIS1	93,97	STAT5	CIS1	6776	1154	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Granulocyte_macrophage_colony-stimulating_factor and interleukin-5 activate STAT5 and induce CIS1 mRNA in human peripheral blood eosinophils .
16476059	0	STAT5	22,27	CTLA-4	0,6	STAT5	CTLA-4	6776	1493	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription .
10601272	0	STAT5	53,58	CYP2C12	26,33	STAT5	CYP2C12	24918(Tax:10116)	25011(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cooperative regulation of CYP2C12 gene expression by STAT5 and liver-specific factors in female rats .
17239351	0	STAT5	186,191	CYP2C12	13,20	STAT5	CYP2C12	24918(Tax:10116)	25011(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY decrease|nmod|activation due|nmod|decrease correlated|advcl|due correlated|nsubj|Induction Induction|nmod|expression expression|nummod|END_ENTITY	Induction of CYP2C12 expression in senescent male rats is well correlated to an increase of HNF3beta expression , while the decline of CYP2C11 expression is unlikely due to a decrease of STAT5 activation .
9837784	0	STAT5	25,30	CrkL	15,19	STAT5	CrkL	6776	1399	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CrkL with STAT5 in hematopoietic cells stimulated by granulocyte-macrophage_colony-stimulating_factor or erythropoietin .
18945591	0	STAT5	15,20	Csf2	71,75	STAT5	Csf2	20850(Tax:10090)	12981(Tax:10090)	Gene	Gene	binding|compound|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic -LRB- NOD -RRB- mouse myeloid cells .
24155890	0	STAT5	20,25	Dpf3	39,43	STAT5	Dpf3	6776	8110	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a STAT5 target gene , Dpf3 , provides novel insights in chronic_lymphocytic_leukemia .
12954715	0	STAT5	125,130	ERBB4	92,97	STAT5	ERBB4	20850(Tax:10090)	13869(Tax:10090)	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5 .
16982325	0	STAT5	52,57	Erythropoietin	0,14	STAT5	Erythropoietin	20850(Tax:10090)	13856(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces sustained phosphorylation of STAT5 in primitive but not definitive erythrocytes generated from mouse embryonic stem cells .
24947990	0	STAT5	65,70	FOXP3	94,99	STAT5	FOXP3	6776	50943	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|END_ENTITY	Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4 + FOXP3 - cells versus regulatory T cells : a whole blood perspective .
24587342	0	STAT5	10,15	FRA2	0,4	STAT5	FRA2	6776	2355	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells .
17182565	0	STAT5	29,34	Foxp3	81,86	STAT5	Foxp3	20850(Tax:10090)	20371(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nsubjpass|activation required|nmod|development development|nmod|cells cells|amod|END_ENTITY	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells .
21779476	0	STAT5	75,80	Growth_Hormone	17,31	STAT5	Growth Hormone	20850(Tax:10090)	14599(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Context-Specific Growth_Hormone Signaling through the Transcription Factor STAT5 : Implications for the Etiology of Hepatosteatosis_and_Hepatocellular_Carcinoma .
10050749	0	STAT5	98,103	Growth_hormone	0,14	STAT5	Growth hormone	6776	2688	Gene	Gene	action|nmod|START_ENTITY induces|nmod|action induces|nsubj|END_ENTITY	Growth_hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1alpha .
10752065	0	STAT5	31,36	Growth_hormone	0,14	STAT5	Growth hormone	24918(Tax:10116)	81668(Tax:10116)	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Growth_hormone pulse-activated STAT5 signalling : a unique regulatory mechanism governing sexual dimorphism of liver gene expression .
11145745	0	STAT5	105,110	Growth_hormone	0,14	STAT5	Growth hormone	6776	2688	Gene	Gene	activation|nmod|START_ENTITY depends|nmod|activation depends|nsubj|cells cells|amod|END_ENTITY	Growth_hormone - and prolactin-induced proliferation_of_insulinoma cells , INS-1 , depends on activation of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- .
12604355	0	STAT5	43,48	Growth_hormone	0,14	STAT5	Growth hormone	20850(Tax:10090)	14599(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY activates|dobj|proteins activates|nsubj|END_ENTITY	Growth_hormone , but not insulin , activates STAT5 proteins in adipocytes in vitro and in vivo .
8702683	0	STAT5	64,69	Growth_hormone	0,14	STAT5	Growth hormone	20850(Tax:10090)	14599(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY promotes|dobj|association promotes|nsubj|END_ENTITY	Growth_hormone promotes the association of transcription factor STAT5 with the growth_hormone receptor .
21263150	0	STAT5	44,49	HIF2alpha	18,27	STAT5	HIF2alpha	6776	2034	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of HIF2alpha as an important STAT5 target gene in human hematopoietic stem cells .
15528362	0	STAT5	17,22	IFN-gamma	44,53	STAT5	IFN-gamma	6776	3458	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression .
23504816	0	STAT5	59,64	IGF-1	0,5	STAT5	IGF-1	6776	3479	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	IGF-1 stimulated upregulation of cyclin_D1 is mediated via STAT5 signaling pathway in neuronal cells .
22993203	0	STAT5	32,37	IL-17A	54,60	STAT5	IL-17A	20850(Tax:10090)	16171(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes .
10815800	0	STAT5	88,93	IL-2	0,4	STAT5	IL-2	6776	3558	Gene	Gene	factors|compound|START_ENTITY induce|nmod|factors induce|nsubj|END_ENTITY	IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells .
17130555	0	STAT5	65,70	IL-2	60,64	STAT5	IL-2	6776	3558	Gene	Gene	dependent|dep|START_ENTITY END_ENTITY|dep|dependent	Upregulation of Foxp3 expression in mouse and human Treg is IL-2 / STAT5 dependent : implications for the NOD STAT5B mutation in diabetes pathogenesis .
17182565	0	STAT5	29,34	IL-2	0,4	STAT5	IL-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells .
18023521	0	STAT5	19,24	IL-2	0,4	STAT5	IL-2	6776	3558	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells , HOZOT .
19675167	0	STAT5	85,90	IL-2	66,70	STAT5	IL-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY survival|parataxis|signaling survival|nmod|autoimmunity autoimmunity|nmod|END_ENTITY	Self-peptides prolong survival in murine autoimmunity via reduced IL-2 / IL-7-mediated STAT5 signaling , CD8 coreceptor , and V alpha 2 down-regulation .
21329987	0	STAT5	77,82	IL-2	72,76	STAT5	IL-2	6776	3558	Gene	Gene	signalling|compound|START_ENTITY signalling|compound|END_ENTITY	Mechanisms involved in the expansion of Tregs during pregnancy : role of IL-2 / STAT5 signalling .
23451206	0	STAT5	53,58	IL-2	40,44	STAT5	IL-2	6776	3558	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid_cancer cells .
24587342	0	STAT5	10,15	IL-2	41,45	STAT5	IL-2	6776	3558	Gene	Gene	gene|compound|START_ENTITY gene|acl|regulated regulated|nmod|END_ENTITY	FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells .
24829413	0	STAT5	20,25	IL-2	0,4	STAT5	IL-2	6776	3558	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	IL-2 phosphorylates STAT5 to drive IFN-y production and activation of human dendritic cells .
9395528	0	STAT5	15,20	IL-2	107,111	STAT5	IL-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	dimers|nummod|START_ENTITY Interaction|nmod|dimers mediates|nsubj|Interaction mediates|dobj|stimulation stimulation|nmod|transcription transcription|amod|alpha alpha|amod|END_ENTITY	Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin_2 -LRB- IL-2 -RRB- stimulation of IL-2 receptor alpha gene transcription .
9395528	0	STAT5	15,20	IL-2	86,90	STAT5	IL-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	dimers|nummod|START_ENTITY Interaction|nmod|dimers mediates|nsubj|Interaction mediates|dobj|stimulation stimulation|appos|END_ENTITY	Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin_2 -LRB- IL-2 -RRB- stimulation of IL-2 receptor alpha gene transcription .
9398404	0	STAT5	43,48	IL-2	0,4	STAT5	IL-2	6776	3558	Gene	Gene	isoforms|nummod|START_ENTITY heterodimerization|nmod|isoforms induce|dobj|heterodimerization induce|nsubj|END_ENTITY	IL-2 and IL-7 induce heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblasts .
9531312	0	STAT5	43,48	IL-2	29,33	STAT5	IL-2	6776	3558	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|growth growth|nmod|END_ENTITY	Regulation of cell growth by IL-2 : role of STAT5 in protection from apoptosis but not in cell cycle progression .
18296629	0	STAT5	53,58	IL-21	0,5	STAT5	IL-21	6776	59067	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	IL-21 is expressed in Hodgkin_lymphoma and activates STAT5 : evidence that activated STAT5 is required for Hodgkin_lymphomagenesis .
25821217	0	STAT5	40,45	IL-25	8,13	STAT5	IL-25	6776	64806	Gene	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	A Novel IL-25 Signaling Pathway through STAT5 .
22102340	0	STAT5	0,5	IL-3	26,30	STAT5	IL-3	6776	3562	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	STAT5 in human basophils : IL-3 is required for its Fc __ RI-mediated phosphorylation .
22854263	0	STAT5	15,20	IL-6	0,4	STAT5	IL-6	20850(Tax:10090)	16193(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	IL-6 activates STAT5 in T cells .
23033267	0	STAT5	23,28	Id2	61,64	STAT5	Id2	6776	3398	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The signal transducers STAT5 and STAT3 control expression of Id2 and E2-2 during dendritic cell development .
11435608	0	STAT5	102,107	Interleukin-2	0,13	STAT5	Interleukin-2	6776	3558	Gene	Gene	mechanism|nmod|START_ENTITY inhibits|nmod|mechanism inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits glucocorticoid_receptor transcriptional activity through a mechanism involving STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- but not AP-1 .
17363300	0	STAT5	28,33	Interleukin-2	0,13	STAT5	Interleukin-2	6776	3558	Gene	Gene	T|compound|START_ENTITY signaling|nmod|T signaling|compound|END_ENTITY	Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation .
23167249	0	STAT5	142,147	Interleukin-2	0,13	STAT5	Interleukin-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY suppresses|nmod|pathways END_ENTITY|parataxis|suppresses	Interleukin-2 / anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced_arthritis in mice by fortifying interleukin-2 / STAT5 signalling pathways .
8617237	0	STAT5	28,33	Interleukin-2	0,13	STAT5	Interleukin-2	6776	3558	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway .
20974963	0	STAT5	38,43	JAK1	72,76	STAT5	JAK1	6776	3716	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Thymic_stromal_lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling .
10585851	0	STAT5	188,193	JAK2	130,134	STAT5	JAK2	24918(Tax:10116)	24514(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_5|appos|START_ENTITY janus_kinase_2|dep|signal_transducer_and_activator_of_transcription_5 janus_kinase_2|appos|END_ENTITY	Stimulation of pancreatic beta-cell proliferation by growth_hormone is glucose-dependent : signal transduction via janus_kinase_2 -LRB- JAK2 -RRB- / signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- with no crosstalk to insulin receptor substrate-mediated mitogenic signalling .
12107179	0	STAT5	197,202	JAK2	139,143	STAT5	JAK2	24918(Tax:10116)	24514(Tax:10116)	Gene	Gene	system|appos|START_ENTITY transducers|nmod|system transducers|appos|END_ENTITY	1Alpha,25-dihydroxyvitamin _ D3 inhibits GH-induced expression of SOCS-3 and CIS and prolongs growth hormone signaling via the Janus_kinase -LRB- JAK2 -RRB- / signal transducers and activators of transcription -LRB- STAT5 -RRB- system in osteoblast-like cells .
15671147	0	STAT5	65,70	JAK2	118,122	STAT5	JAK2	6776	3717	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Stem_cell_factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase .
20028972	0	STAT5	0,5	JAK2	103,107	STAT5	JAK2	20850(Tax:10090)	16452(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY critical|nsubj|activation critical|nmod|transformation transformation|acl|mediated mediated|nmod|mutant mutant|compound|END_ENTITY	STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant .
22382519	0	STAT5	173,178	JAK2	115,119	STAT5	JAK2	6776	3717	Gene	Gene	transcription-5|appos|START_ENTITY transducer|nmod|transcription-5 signalling|dep|transducer Janus_kinase-2|dep|signalling Janus_kinase-2|appos|END_ENTITY	Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus_kinase-2 -LRB- JAK2 -RRB- / signal transducer and activator of transcription-5 -LRB- STAT5 -RRB- signalling .
26575024	0	STAT5	74,79	Jak2	24,28	STAT5	Jak2	20850(Tax:10090)	16452(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY has|dobj|effects has|nsubj|END_ENTITY	Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic_cancer .
19775300	0	STAT5	47,52	NPM	77,80	STAT5	NPM	6776	4869	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|mutations mutations|compound|END_ENTITY	FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations .
23451206	0	STAT5	53,58	PDE4B	28,33	STAT5	PDE4B	6776	5142	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid_cancer cells .
19481553	0	STAT5	41,46	Prolactin	0,9	STAT5	Prolactin	24918(Tax:10116)	24683(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Prolactin induces phosphorylation of the STAT5 in adrenal glands of Hatano rats during stress .
21670473	0	STAT5	28,33	SHP2	20,24	STAT5	SHP2	6776	5781	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation , survival , and differentiation of human CD34 + cells .
21205088	0	STAT5	72,77	STAP-2	15,21	STAT5	STAP-2	6776	55620	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast_cancer cells .
17015686	0	STAT5	24,29	STAT3	57,62	STAT5	STAT3	6776	6774	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A preferential role for STAT5 , not constitutively active STAT3 , in promoting survival of a human lymphoid_tumor .
23716595	0	STAT5	0,5	STAT3	18,23	STAT5	STAT3	6776	6774	Gene	Gene	outcompetes|nsubj|START_ENTITY outcompetes|dobj|END_ENTITY	STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6 .
24762632	0	STAT5	53,58	STAT3	0,5	STAT5	STAT3	6776	6774	Gene	Gene	Modulation|nmod|START_ENTITY Activity|dep|Modulation Activity|compound|END_ENTITY	STAT3 Activity and Function in Cancer : Modulation by STAT5 and miR-146b .
26976954	0	STAT5	14,19	STAT3	0,5	STAT5	STAT3	6776	6774	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	STAT3 Impairs STAT5 Activation in the Development of IL-9-Secreting T Cells .
8977235	0	STAT5	107,112	STAT3	121,126	STAT5	STAT3	6776	6774	Gene	Gene	activation|nmod|START_ENTITY granulocyte_colony-stimulating_factor|nmod|activation induced|nmod|granulocyte_colony-stimulating_factor pathways|acl|induced signaling|dobj|pathways required|advcl|signaling required|nsubjpass|END_ENTITY	Multiple signaling pathways induced by granulocyte_colony-stimulating_factor involving activation of JAKs , STAT5 , and/or STAT3 are required for regulation of three distinct classes of immediate early genes .
12829027	0	STAT5	121,126	Stem_cell_factor	0,16	STAT5	Stem cell factor	6776	4254	Gene	Gene	signal_transducer_and_activator_of_transcription_5|appos|START_ENTITY transactivation|nmod|signal_transducer_and_activator_of_transcription_5 enhances|dobj|transactivation enhances|nsubj|END_ENTITY	Stem_cell_factor enhances erythropoietin-mediated transactivation of signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- via the PKA/CREB pathway .
15671147	0	STAT5	65,70	Stem_cell_factor	0,16	STAT5	Stem cell factor	6776	4254	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Stem_cell_factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase .
24006458	0	STAT5	7,12	T-bet	23,28	STAT5	T-bet	20850(Tax:10090)	57765(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6 / TGF-b1 signaling .
24376517	0	STAT5	46,51	TMPRSS6	23,30	STAT5	TMPRSS6	20850(Tax:10090)	71753(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Inflammation regulates TMPRSS6 expression via STAT5 .
7544303	0	STAT5	72,77	TPO	16,19	STAT5	TPO	6776	7066	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|Thrombopoietin Thrombopoietin|appos|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces tyrosine phosphorylation and activation of STAT5 and STAT3 .
11097834	0	STAT5	64,69	Thrombopoietin	0,14	STAT5	Thrombopoietin	6776	7066	Gene	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	Thrombopoietin and interleukin-2 induce association of CRK with STAT5 .
7544303	0	STAT5	72,77	Thrombopoietin	0,14	STAT5	Thrombopoietin	6776	7066	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces tyrosine phosphorylation and activation of STAT5 and STAT3 .
9845531	0	STAT5	48,53	Thrombopoietin	0,14	STAT5	Thrombopoietin	6776	7066	Gene	Gene	Crkl|nmod|START_ENTITY association|nmod|Crkl induces|dobj|association induces|nsubj|END_ENTITY	Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets .
10050877	0	STAT5	20,25	c-Rel	11,16	STAT5	c-Rel	6776	5966	Gene	Gene	target|compound|START_ENTITY END_ENTITY|nmod|target	Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells .
10064602	0	STAT5	56,61	cyclin_D1	34,43	STAT5	cyclin D1	6776	595	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Transcriptional regulation of the cyclin_D1 promoter by STAT5 : its involvement in cytokine-dependent growth of hematopoietic cells .
21617857	0	STAT5	55,60	cyclooxygenase-2	15,31	STAT5	cyclooxygenase-2	6776	5743	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	EGF stimulates cyclooxygenase-2 expression through the STAT5 signaling pathway in human lung_adenocarcinoma A549 cells .
10339482	0	STAT5	61,66	erythropoietin	84,98	STAT5	erythropoietin	6776	2056	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Protein_kinase_B _ -LRB- c-Akt -RRB- , phosphatidylinositol 3-kinase , and STAT5 are activated by erythropoietin -LRB- EPO -RRB- in HCD57 erythroid cells but are constitutively active in an EPO-independent , apoptosis-resistant subclone -LRB- HCD57-SREI cells -RRB- .
11696536	0	STAT5	83,88	erythropoietin	114,128	STAT5	erythropoietin	20850(Tax:10090)	13856(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Regulation of Socs gene expression by the proto-oncoprotein GFI-1B : two routes for STAT5 target gene induction by erythropoietin .
16407271	0	STAT5	117,122	erythropoietin	25,39	STAT5	erythropoietin	6776	2056	Gene	Gene	activation|nmod|START_ENTITY require|dobj|activation require|nsubj|effects effects|nmod|END_ENTITY	Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways .
21619451	0	STAT5	28,33	erythropoietin	123,137	STAT5	erythropoietin	6776	2056	Gene	Gene	phosphorylation|compound|START_ENTITY analysis|nmod|phosphorylation treated|nsubj|analysis treated|nmod|END_ENTITY	Flow cytometric analysis of STAT5 phosphorylation and CD95 expression in CD4 + T lymphocytes treated with recombinant human erythropoietin .
22093990	0	STAT5	1,6	erythropoietin	33,47	STAT5	erythropoietin	6776	2056	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	-LSB- STAT5 phosphorylation levels of erythropoietin and thrombopoietin_receptors in CD34 -LRB- + -RRB- CD59 -LRB- - -RRB- and CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- bone marrow cells of patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
8665851	0	STAT5	111,116	erythropoietin	75,89	STAT5	erythropoietin	20850(Tax:10090)	13856(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY crucial|nmod|activation Identification|amod|crucial Identification|nmod|residues residues|nmod|domain domain|nmod|receptor receptor|compound|END_ENTITY	Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation .
9079629	0	STAT5	0,5	erythropoietin	33,47	STAT5	erythropoietin	6776	2056	Gene	Gene	activation|compound|START_ENTITY correlates|nsubj|activation correlates|nmod|differentiation differentiation|compound|END_ENTITY	STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line .
11158330	0	STAT5	23,28	glucocorticoid_receptor	188,211	STAT5	glucocorticoid receptor	6776	2908	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Cooperative effects of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- and C/EBPbeta -LRB- CCAAT/enhancer-binding _ protein-beta -RRB- on beta-casein gene transcription are mediated by the glucocorticoid_receptor .
11122381	0	STAT5	21,26	granulocyte-macrophage_colony-stimulating_factor	41,89	STAT5	granulocyte-macrophage colony-stimulating factor	20850(Tax:10090)	12981(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY activation|nsubj|analysis activation|nmod|END_ENTITY	In vitro analysis of STAT5 activation by granulocyte-macrophage_colony-stimulating_factor .
8977235	0	STAT5	107,112	granulocyte_colony-stimulating_factor	39,76	STAT5	granulocyte colony-stimulating factor	6776	1440	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Multiple signaling pathways induced by granulocyte_colony-stimulating_factor involving activation of JAKs , STAT5 , and/or STAT3 are required for regulation of three distinct classes of immediate early genes .
10585851	0	STAT5	188,193	growth_hormone	53,67	STAT5	growth hormone	24918(Tax:10116)	81668(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_5|appos|START_ENTITY janus_kinase_2|dep|signal_transducer_and_activator_of_transcription_5 transduction|nmod|janus_kinase_2 substrate-mediated|nsubj|transduction glucose-dependent|parataxis|substrate-mediated glucose-dependent|nsubj|Stimulation Stimulation|nmod|proliferation proliferation|nmod|END_ENTITY	Stimulation of pancreatic beta-cell proliferation by growth_hormone is glucose-dependent : signal transduction via janus_kinase_2 -LRB- JAK2 -RRB- / signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- with no crosstalk to insulin receptor substrate-mediated mitogenic signalling .
10674400	0	STAT5	15,20	growth_hormone	165,179	STAT5	growth hormone	24918(Tax:10116)	81668(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|control control|nmod|gene gene|nmod|END_ENTITY	Involvement of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- and HNF-4 -LRB- hepatocyte_nuclear_factor_4 -RRB- in the transcriptional control of the hnf6 gene by growth_hormone .
23631823	0	STAT5	56,61	growth_hormone	32,46	STAT5	growth hormone	20850(Tax:10090)	14599(Tax:10090)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin and IGF-I on growth_hormone - induced STAT5 activation in 3T3-F442A adipocytes .
8732682	0	STAT5	32,37	growth_hormone	76,90	STAT5	growth hormone	6776	2688	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization and cloning of STAT5 from IM-9 cells and its activation by growth_hormone .
10373548	0	STAT5	78,83	interleukin-2	49,62	STAT5	interleukin-2	6776	3558	Gene	Gene	proliferation|nummod|START_ENTITY phosphorylated|nsubj|proliferation phosphorylated|nmod|END_ENTITY	SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation .
12425996	0	STAT5	27,32	interleukin-2	47,60	STAT5	interleukin-2	6776	3558	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils .
23167249	0	STAT5	142,147	interleukin-2	128,141	STAT5	interleukin-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Interleukin-2 / anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced_arthritis in mice by fortifying interleukin-2 / STAT5 signalling pathways .
25509109	0	STAT5	5,10	interleukin-2	59,72	STAT5	interleukin-2	6776	3558	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|expression expression|nmod|alpha-subunit alpha-subunit|nmod|receptor receptor|compound|END_ENTITY	-LSB- The STAT5 signaling in the expression of alpha-subunit of interleukin-2 receptor in human_blood_lymphocytes -RSB- .
15677474	0	STAT5	112,117	prolactin	44,53	STAT5	prolactin	6776	5617	Gene	Gene	interacting|nmod|START_ENTITY signaling|advcl|interacting END_ENTITY|acl|signaling	Suppressor_of_cytokine_signaling_7 inhibits prolactin , growth_hormone , and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation .
15855883	0	STAT5	85,90	prolactin	11,20	STAT5	prolactin	24918(Tax:10116)	24683(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY modulation|nmod|expression evidence|nmod|modulation Effects|dep|evidence Effects|nmod|END_ENTITY	Effects of prolactin on hypothalamic supraoptic neurones : evidence for modulation of STAT5 expression and electrical activity .
11435608	0	STAT5	102,107	signal_transducer_and_activator_of_transcription_5	109,159	STAT5	signal transducer and activator of transcription 5	6776	6776	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	Interleukin-2 inhibits glucocorticoid_receptor transcriptional activity through a mechanism involving STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- but not AP-1 .
24753251	0	STAT5	138,143	signal_transducer_and_activator_of_transcription_5	86,136	STAT5	signal transducer and activator of transcription 5	6776	6776	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Regulation of the interferon_regulatory_factor-8 -LRB- IRF-8 -RRB- tumor suppressor gene by the signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- transcription factor in chronic_myeloid_leukemia .
25087955	0	STAT5	115,120	signal_transducer_and_activator_of_transcription_5	63,113	STAT5	signal transducer and activator of transcription 5	6776	6776	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Serotonin suppresses b-casein expression via inhibition of the signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- protein phosphorylation in human mammary epithelial cells MCF-12A .
9774439	0	STAT5	101,106	signal_transducer_and_activator_of_transcription_5	49,99	STAT5	signal transducer and activator of transcription 5	6776	6776	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Proteasomes regulate erythropoietin_receptor and signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- activation .
26059451	0	STAT5A	0,6	DNMT3A	17,23	STAT5A	DNMT3A	6776	1788	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	STAT5A regulates DNMT3A in CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- AML cells .
8695838	0	STAT5A	84,90	Granulocyte-macrophage_colony-stimulating_factor	0,48	STAT5A	Granulocyte-macrophage colony-stimulating factor	6776	1437	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes .
25231404	0	STAT5A	117,123	neuropilin-1	89,101	STAT5A	neuropilin-1	20850(Tax:10090)	18186(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Calreticulin promotes migration and invasion of esophageal_cancer cells by up-regulating neuropilin-1 expression via STAT5A .
22919439	0	STAT5B	44,50	cyclin_D1	71,80	STAT5B	cyclin D1	6777	595	Gene	Gene	expression|nmod|START_ENTITY modifying|nsubj|expression modifying|dobj|levels levels|amod|END_ENTITY	Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin_D1 levels in cancer cells .
23896798	0	STAT5B	1,7	growth_hormone	26,40	STAT5B	growth hormone	6777	2688	Gene	Gene	deficiency|compound|START_ENTITY deficiency|dep|insensitivity_syndrome insensitivity_syndrome|compound|END_ENTITY	-LSB- STAT5B deficiency : a new growth_hormone insensitivity_syndrome associated to immunological_dysfunction -RSB- .
16882096	0	STAT5B	115,121	signal_transducer_and_activator_of_transcription_5B	57,108	STAT5B	signal transducer and activator of transcription 5B	20851(Tax:10090)	20851(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism and chromosomal localization of the porcine signal_transducer_and_activator_of_transcription_5B gene -LRB- STAT5B -RRB- .
10537141	0	STAT5a	70,76	Growth_hormone	0,14	STAT5a	Growth hormone	24918(Tax:10116)	81668(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY maintains|dobj|activation maintains|nsubj|END_ENTITY	Growth_hormone , but not prolactin , maintains , low-level activation of STAT5a and STAT5b in female rat liver .
17287404	0	STAT5b	88,94	Growth_hormone	0,14	STAT5b	Growth hormone	6777	2688	Gene	Gene	mutation|amod|START_ENTITY secretion|nmod|mutation secretion|amod|END_ENTITY	Growth_hormone secretion and immunological function of a male patient with a homozygous STAT5b mutation .
17389811	0	STAT5b	125,131	Growth_hormone	0,14	STAT5b	Growth hormone	6777	2688	Gene	Gene	gene|amod|START_ENTITY junction|nmod|gene mutation|nmod|junction insensitivity|dep|mutation insensitivity|amod|END_ENTITY	Growth_hormone insensitivity and severe short_stature in siblings : a novel mutation at the exon 13-intron 13 junction of the STAT5b gene .
22552610	0	STAT5b	42,48	Hsp90a	20,26	STAT5b	Hsp90a	6777	3324	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Hypoxia upregulates Hsp90a expression via STAT5b in cancer cells .
10618497	0	STAT5b	30,36	Insulin	0,7	STAT5b	Insulin	6777	3630	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Insulin selectively activates STAT5b , but not STAT5a , via a JAK2-independent signalling pathway in Kym-1 rhabdomyosarcoma cells .
11414683	0	STAT5b	10,16	alcohol_dehydrogenase	30,51	STAT5b	alcohol dehydrogenase	25126(Tax:10116)	78959(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of STAT5b on rat liver alcohol_dehydrogenase .
20372799	0	STAT5b	50,56	cyclin_D1	15,24	STAT5b	cyclin D1	6777	595	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Hemin inhibits cyclin_D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast_cancer cells .
11751923	0	STAT5b	20,26	epidermal_growth_factor	42,65	STAT5b	epidermal growth factor	6777	1950	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Novel activation of STAT5b in response to epidermal_growth_factor .
10991939	0	STAT5b	69,75	growth_hormone	100,114	STAT5b	growth hormone	25126(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth_hormone .
11562369	0	STAT5b	30,36	growth_hormone	100,114	STAT5b	growth hormone	25126(Tax:10116)	81668(Tax:10116)	Gene	Gene	cross-talk|nmod|START_ENTITY HNF3beta|amod|cross-talk HNF3beta|dep|impact impact|nmod|regulation regulation|nmod|expression expression|compound|liver liver|amod|END_ENTITY	Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta : impact on the regulation of growth_hormone pulse-stimulated , male-specific liver cytochrome_P-450 gene expression .
18831980	0	STAT5b	88,94	growth_hormone	58,72	STAT5b	growth hormone	20851(Tax:10090)	14599(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY stimulation|nmod|phosphorylation stimulation|amod|END_ENTITY	Increased SULT1E1 activity in HepG2 hepatocytes decreases growth_hormone stimulation of STAT5b phosphorylation .
21106534	0	STAT5b	36,42	hTid1	21,26	STAT5b	hTid1	6777	9093	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction .
19630967	0	STAT5b	70,76	signal_transducer_and_activator_of_transcription_5b	17,68	STAT5b	signal transducer and activator of transcription 5b	6777	6777	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for signal_transducer_and_activator_of_transcription_5b -LRB- STAT5b -RRB- in beta1-integrin-mediated human breast_cancer cell migration .
9490672	0	STAT5beta	19,28	serine_protease	66,81	STAT5beta	serine protease	6777	2147	Gene	Gene	generated|nsubjpass|START_ENTITY generated|nmod|END_ENTITY	Carboxyl-truncated STAT5beta is generated by a nucleus-associated serine_protease in early hematopoietic progenitors .
18191727	0	STAT6	34,39	CCL17	59,64	STAT6	CCL17	6778	6361	Gene	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	Identification of a distal tandem STAT6 element within the CCL17 locus .
9796920	0	STAT6	0,5	CD23	30,34	STAT6	CD23	20852(Tax:10090)	14128(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	STAT6 , NF-kappaB and C/EBP in CD23 expression and IgE production .
15661890	0	STAT6	21,26	IFN-gamma	0,9	STAT6	IFN-gamma	20852(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor .
10514388	0	STAT6	16,21	IL-13	0,5	STAT6	IL-13	20852(Tax:10090)	16163(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	IL-13 activates STAT6 and inhibits liver_injury induced by ischemia/reperfusion .
12935900	0	STAT6	51,56	IL-13	83,88	STAT6	IL-13	6778	3596	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation .
21814192	0	STAT6	0,5	IL-13	17,22	STAT6	IL-13	6778	3596	Gene	Gene	links|nsubj|START_ENTITY links|dobj|stimulation stimulation|compound|END_ENTITY	STAT6 links IL-4 / IL-13 stimulation with pendrin expression in asthma and chronic_obstructive_pulmonary_disease .
26423151	0	STAT6	116,121	IL-13	96,101	STAT6	IL-13	20852(Tax:10090)	16163(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic_Steatosis in Mice Dependent upon IL-13 Activation of STAT6 .
10072514	0	STAT6	38,43	IL-4	0,4	STAT6	IL-4	6778	3565	Gene	Gene	isoform|compound|START_ENTITY activates|dobj|isoform activates|nsubj|END_ENTITY	IL-4 preferentially activates a novel STAT6 isoform in mast cells .
10452990	0	STAT6	77,82	IL-4	32,36	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Inhibition|dep|role Inhibition|nmod|expression expression|nmod|END_ENTITY	Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells : role of STAT6 and phosphatidylinositol 3 ' - kinase .
10939617	0	STAT6	89,94	IL-4	47,51	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY injury|dep|role injury|nmod|END_ENTITY	Reduced hepatic_ischemia / reperfusion injury by IL-4 : potential anti-inflammatory role of STAT6 .
11164892	0	STAT6	43,48	IL-4	0,4	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY phosphorylation|nmod|domain induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-4 induces serine phosphorylation of the STAT6 transactivation domain in B lymphocytes .
11254707	0	STAT6	0,5	IL-4	39,43	STAT6	IL-4	6778	3565	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|fibroblasts fibroblasts|compound|END_ENTITY	STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts .
11292026	0	STAT6	12,17	IL-4	31,35	STAT6	IL-4	6778	3565	Gene	Gene	role|nmod|START_ENTITY role|nmod|production production|compound|END_ENTITY	The role of STAT6 in mast cell IL-4 production .
11709700	0	STAT6	102,107	IL-4	48,52	STAT6	IL-4	6778	3565	Gene	Gene	ERK|compound|START_ENTITY pathways|compound|ERK involvement|nmod|pathways Induction|dep|involvement Induction|nmod|receptor receptor|amod|alpha2-chain alpha2-chain|nmod|END_ENTITY	Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes : involvement of STAT6 , ERK and p38 MAPK pathways .
11872954	0	STAT6	28,33	IL-4	54,58	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	fishing|nmod|START_ENTITY fishing|dep|cross-talk cross-talk|nmod|END_ENTITY	Oligonucleotide fishing for STAT6 : cross-talk between IL-4 and chemokines .
12121972	1	STAT6	59,64	IL-4	81,85	STAT6	IL-4	6778	3565	Gene	Gene	cycling|nmod|START_ENTITY required|nsubjpass|cycling required|nmod|END_ENTITY	Continuous cycling of STAT6 is required for IL-4 signaling .
12244176	0	STAT6	53,58	IL-4	0,4	STAT6	IL-4	6778	3565	Gene	Gene	processing|nmod|START_ENTITY induces|dobj|processing induces|nsubj|END_ENTITY	IL-4 induces the proteolytic processing of mast cell STAT6 .
12574343	0	STAT6	126,131	IL-4	23,27	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	found|nmod|START_ENTITY found|nsubj|regulate regulate|compound|END_ENTITY	The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism .
12960353	0	STAT6	21,26	IL-4	16,20	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Crucial role of IL-4 / STAT6 in T cell-mediated hepatitis : up-regulating eotaxins and IL-5 and recruiting leukocytes .
14978013	0	STAT6	109,114	IL-4	70,74	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|Induction Induction|nmod|expression expression|nmod|ligation ligation|compound|END_ENTITY	Induction of activation-induced_cytidine_deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB .
15004182	0	STAT6	81,86	IL-4	0,4	STAT6	IL-4	6778	3565	Gene	Gene	requirement|nmod|START_ENTITY END_ENTITY|dep|requirement	IL-4 and IL-13 up-regulate intestinal trefoil factor expression : requirement for STAT6 and de novo protein synthesis .
15620709	0	STAT6	20,25	IL-4	68,72	STAT6	IL-4	6778	3565	Gene	Gene	siRNAs|nummod|START_ENTITY silencing|nmod|siRNAs release|dep|silencing release|nmod|END_ENTITY	Gene silencing with STAT6 specific siRNAs blocks eotaxin release in IL-4 / TNFalpha stimulated human epithelial cells .
15661890	0	STAT6	21,26	IL-4	80,84	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|advcl|inhibiting inhibiting|nmod|receptor receptor|compound|END_ENTITY	IFN-gamma suppresses STAT6 phosphorylation by inhibiting its recruitment to the IL-4 receptor .
15922518	0	STAT6	92,97	IL-4	41,45	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	element|nmod|START_ENTITY requires|dobj|element requires|nsubj|Induction Induction|nmod|transcription transcription|nmod|END_ENTITY	Induction of arginase_I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta .
16393965	0	STAT6	47,52	IL-4	76,80	STAT6	IL-4	6778	3565	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|binding binding|nmod|END_ENTITY	Progesterone-induced_blocking_factor activates STAT6 via binding to a novel IL-4 receptor .
16810739	0	STAT6	46,51	IL-4	0,4	STAT6	IL-4	6778	3565	Gene	Gene	sites|compound|START_ENTITY TARC/CCL17|nmod|sites expression|nmod|TARC/CCL17 induces|dobj|expression induces|nsubj|END_ENTITY	IL-4 induces expression of TARC/CCL17 via two STAT6 binding sites .
17276885	0	STAT6	18,23	IL-4	117,121	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|dep|role role|nmod|receptors receptors|nmod|regulation regulation|nmod|production production|compound|END_ENTITY	Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion : role of H1 receptors in the regulation of IL-4 production .
17276885	0	STAT6	18,23	IL-4	59,63	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|nmod|effects effects|nmod|secretion secretion|compound|END_ENTITY	Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion : role of H1 receptors in the regulation of IL-4 production .
17347574	0	STAT6	24,29	IL-4	105,109	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	mice|nummod|START_ENTITY phenotype|nmod|mice implies|nsubj|phenotype implies|dobj|requirements requirements|nmod|functions functions|compound|END_ENTITY	Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions .
17347574	0	STAT6	65,70	IL-4	105,109	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	requirements|compound|START_ENTITY requirements|nmod|functions functions|compound|END_ENTITY	Unexpected phenotype of STAT6 heterozygous mice implies distinct STAT6 dosage requirements for different IL-4 functions .
19419769	0	STAT6	109,114	IL-4	0,4	STAT6	IL-4	6778	3565	Gene	Gene	mechanisms|amod|START_ENTITY alters|nmod|mechanisms alters|nsubj|END_ENTITY	IL-4 alters expression patterns of storage components of vascular endothelial cell-specific granules through STAT6 - and SOCS-1-dependent mechanisms .
19488417	0	STAT6	46,51	IL-4	0,4	STAT6	IL-4	6778	3565	Gene	Gene	translocalization|nmod|START_ENTITY translocalization|compound|END_ENTITY	IL-4 independent nuclear translocalization of STAT6 in HeLa cells by entry of Toxoplasma_gondii .
19540524	0	STAT6	33,38	IL-4	9,13	STAT6	IL-4	6778	3565	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Impaired IL-4 phosphorylation of STAT6 in EBV transformed B-cells .
20010912	0	STAT6	35,40	IL-4	30,34	STAT6	IL-4	6778	3565	Gene	Gene	signalling|nsubj|START_ENTITY requirements|parataxis|signalling requirements|nmod|END_ENTITY	Differential requirements for IL-4 / STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses .
20876453	0	STAT6	0,5	IL-4	51,55	STAT6	IL-4	6778	3565	Gene	Gene	START_ENTITY|acl|signaling signaling|dep|activated activated|nmod|END_ENTITY	STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr_virus-encoded protein LMP-1 in absence of EBNA-2 : implications for the type II EBV latent gene expression in Hodgkin_lymphoma .
20980261	0	STAT6	101,106	IL-4	96,100	STAT6	IL-4	6778	3565	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|naive naive|ccomp|mediated mediated|nmod|END_ENTITY	Inhibition of suppressive T_cell_factor_1 -LRB- TCF-1 -RRB- isoforms in naive CD4 + T cells is mediated by IL-4 / STAT6 signaling .
21149710	0	STAT6	5,10	IL-4	0,4	STAT6	IL-4	6778	3565	Gene	Gene	axis|nummod|START_ENTITY regulates|nsubj|axis END_ENTITY|appos|regulates	IL-4 / STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity .
21814192	0	STAT6	0,5	IL-4	12,16	STAT6	IL-4	6778	3565	Gene	Gene	links|nsubj|START_ENTITY links|dobj|stimulation stimulation|compound|END_ENTITY	STAT6 links IL-4 / IL-13 stimulation with pendrin expression in asthma and chronic_obstructive_pulmonary_disease .
22730821	0	STAT6	32,37	IL-4	27,31	STAT6	IL-4	100726686	100720403	Gene	Gene	expressions|dep|START_ENTITY expressions|nmod|END_ENTITY	-LSB- Histologic expressions of IL-4 / STAT6 in nasal mucosa of guinea_pig allergic_rhinitis models and effect of glucocorticoid on them -RSB- .
26388667	0	STAT6	152,157	IL-4	147,151	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Wogonin , a plant flavone from Scutellariae radix , attenuated ovalbumin-induced airway_inflammation in mouse model of asthma via the suppression of IL-4 / STAT6 signaling .
26388667	0	STAT6	152,157	IL-4	147,151	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Wogonin , a plant flavone from Scutellariae radix , attenuated ovalbumin-induced airway_inflammation in mouse model of asthma via the suppression of IL-4 / STAT6 signaling .
26781462	0	STAT6	48,53	IL-4	37,41	STAT6	IL-4	6778	3565	Gene	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|changes changes|nmod|expression expression|nmod|END_ENTITY	Analysis of changes in expression of IL-4 / IL-13 / STAT6 pathway and correlation with the selected clinical parameters in patients with atopic_asthma .
26993600	0	STAT6	75,80	IL-4	35,39	STAT6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY suppressive|nmod|activation suppressive|dobj|effect effect|nmod|END_ENTITY	Tumor growth suppressive effect of IL-4 through p21-mediated activation of STAT6 in IL-4Ra overexpressed_melanoma models .
9618271	0	STAT6	97,102	IL-4	53,57	STAT6	IL-4	6778	3565	Gene	Gene	activation|nmod|START_ENTITY alpha|nmod|activation alpha|nsubj|Identification Identification|nmod|portions portions|nmod|receptor receptor|compound|END_ENTITY	Identification of the critical portions of the human IL-4 receptor alpha chain for activation of STAT6 .
9686563	0	STAT6	31,36	IL-4	66,70	STAT6	IL-4	6778	3565	Gene	Gene	form|nmod|START_ENTITY mimic|nsubj|form mimic|dobj|effects effects|nmod|END_ENTITY	A conditionally active form of STAT6 can mimic certain effects of IL-4 .
22578203	0	STAT6	17,22	IgE	42,45	STAT6	IgE	6778	3497	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Polymorphisms of STAT6 and specific serum IgE levels in patients with penicillin allergy .
10882748	0	STAT6	57,62	Interleukin-15	0,14	STAT6	Interleukin-15	20852(Tax:10090)	16168(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells .
10631093	0	STAT6	23,28	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	activation|nummod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Interleukin-4 mediates STAT6 activation in 3T3-L1 preadipocytes but not adipocytes .
10982806	0	STAT6	14,19	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	represses|nsubj|START_ENTITY END_ENTITY|parataxis|represses	Interleukin-4 / STAT6 represses STAT1 and NF-kappa_B-dependent transcription through distinct mechanisms .
11266117	0	STAT6	103,108	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	monomer|compound|START_ENTITY binding|nmod|monomer evidence|nmod|binding STAT6|dep|evidence containing|dobj|STAT6 complexes|acl|containing induces|dobj|complexes induces|nsubj|END_ENTITY	Interleukin-4 induces two distinct GAS-binding complexes containing STAT6 : evidence for DNA binding of STAT6 monomer .
11266117	0	STAT6	68,73	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	containing|dobj|START_ENTITY complexes|acl|containing induces|dobj|complexes induces|nsubj|END_ENTITY	Interleukin-4 induces two distinct GAS-binding complexes containing STAT6 : evidence for DNA binding of STAT6 monomer .
17134490	0	STAT6	103,108	Interleukin-4	0,13	STAT6	Interleukin-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	sites|compound|START_ENTITY mediated|nmod|sites mediated|nsubjpass|induction induction|amod|END_ENTITY	Interleukin-4 induction of the CC chemokine TARC -LRB- CCL17 -RRB- in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter .
18251702	0	STAT6	123,128	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway stimulate|nmod|cells END_ENTITY|dep|stimulate	Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway .
19857574	0	STAT6	60,65	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	activation|nmod|START_ENTITY protein|nmod|activation upregulates|dobj|protein upregulates|nsubj|END_ENTITY	Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells .
21751242	0	STAT6	59,64	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6 : a novel mechanism mediating its blockade of osteoclastogenesis .
23935100	0	STAT6	77,82	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-4 induces senescence in human renal_carcinoma cell lines through STAT6 and p38 MAPK .
9092569	0	STAT6	113,118	Interleukin-4	0,13	STAT6	Interleukin-4	6778	3565	Gene	Gene	antagonism|compound|START_ENTITY mediated|nmod|antagonism mediated|nsubjpass|suppression suppression|amod|END_ENTITY	Interleukin-4 suppression of tumor_necrosis_factor_alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB .
17652621	0	STAT6	131,136	JAK2	97,101	STAT6	JAK2	6778	3717	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin_lymphoma is accompanied by high JAK2 expression and activation of STAT6 .
20876453	0	STAT6	0,5	LMP-1	127,132	STAT6	LMP-1	6778	17494204	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr_virus-encoded protein LMP-1 in absence of EBNA-2 : implications for the type II EBV latent gene expression in Hodgkin_lymphoma .
21751242	0	STAT6	59,64	NFATc1	37,43	STAT6	NFATc1	6778	4772	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin-4 inhibits RANKL-induced NFATc1 expression via STAT6 : a novel mechanism mediating its blockade of osteoclastogenesis .
18716132	0	STAT6	55,60	PTP1B	0,5	STAT6	PTP1B	6778	5770	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PTP1B is a negative regulator of interleukin_4-induced STAT6 signaling .
16393965	0	STAT6	47,52	Progesterone-induced_blocking_factor	0,36	STAT6	Progesterone-induced blocking factor	6778	10464	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Progesterone-induced_blocking_factor activates STAT6 via binding to a novel IL-4 receptor .
15613279	0	STAT6	16,21	SHP-1	0,5	STAT6	SHP-1	20852(Tax:10090)	23957(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner .
10485906	0	STAT6	34,39	SOCS-1	88,94	STAT6	SOCS-1	6778	8651	Gene	Gene	activation|nmod|START_ENTITY inhibit|dobj|activation inhibit|advcl|inducing inducing|dobj|expression expression|compound|END_ENTITY	Interferons inhibit activation of STAT6 by interleukin_4 in human monocytes by inducing SOCS-1 gene expression .
12138096	0	STAT6	48,53	SRC-1	85,90	STAT6	SRC-1	6778	8648	Gene	Gene	domain|nmod|START_ENTITY motif|nmod|domain mediates|nsubj|motif mediates|dobj|recruitment recruitment|nmod|END_ENTITY	An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1 / SRC-1 .
14757047	0	STAT6	75,80	SRC-1	24,29	STAT6	SRC-1	6778	8648	Gene	Gene	domain|compound|START_ENTITY motif|nmod|domain bound|nmod|motif bound|nsubj|domain domain|compound|END_ENTITY	Structure of the NCoA-1 / SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain .
14993689	0	STAT6	122,127	SRC-1	71,76	STAT6	SRC-1	6778	8648	Gene	Gene	domain|compound|START_ENTITY motif|nmod|domain bound|nmod|motif bound|nsubj|domain domain|compound|END_ENTITY	Crystallization and preliminary crystallographic studies of the NCoA-1 / SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain .
21148148	0	STAT6	15,20	SRC-1	43,48	STAT6	SRC-1	6778	8648	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of STAT6 with its co-activator SRC-1 / NCoA-1 is regulated by dephosphorylation of the latter via PP2A .
22025716	0	STAT6	52,57	Signal_transducer_and_activator_of_transcription-6	0,50	STAT6	Signal transducer and activator of transcription-6	20852(Tax:10090)	20852(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription-6 -LRB- STAT6 -RRB- inhibition suppresses renal cyst growth in polycystic_kidney_disease .
15199062	0	STAT6	0,5	Socs-1	53,59	STAT6	Socs-1	6778	8651	Gene	Gene	form|nsubj|START_ENTITY form|dobj|complex complex|acl:relcl|modulates modulates|dobj|expression expression|compound|END_ENTITY	STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes .
22909160	0	STAT6	38,43	T-bet	8,13	STAT6	T-bet	6778	30009	Gene	Gene	addition|nmod|START_ENTITY END_ENTITY|nmod|addition	Reduced T-bet in addition to enhanced STAT6 and GATA3 expressing T cells contribute to human allergen-induced late responses .
11009098	0	STAT6	79,84	Th2	25,28	STAT6	Th2	20852(Tax:10090)	15111(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY development|nmod|activation development|amod|END_ENTITY	TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression .
11907063	0	STAT6	132,137	Th2	107,110	STAT6	Th2	20852(Tax:10090)	15111(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY induced|nmod|signaling response|acl|induced response|amod|END_ENTITY	Cutting edge : susceptibility to the larval stage of the helminth parasite Taenia_crassiceps is mediated by Th2 response induced via STAT6 signaling .
19234162	0	STAT6	0,5	Th2	28,31	STAT6	Th2	20852(Tax:10090)	15111(Tax:10090)	Gene	Gene	deletion|compound|START_ENTITY converts|nsubj|deletion converts|xcomp|afflicting afflicting|nsubj|END_ENTITY	STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat -LRB- Y136F -RRB- mice into a lymphoproliferative_disorder involving Th1 and CD8 effector T cells .
20691018	0	STAT6	118,123	Th2	124,127	STAT6	Th2	20852(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Protection against Naegleria_fowleri_infection in mice immunized with Cry1Ac plus amoebic lysates is dependent on the STAT6 Th2 response .
25145352	0	STAT6	49,54	Th2	15,18	STAT6	Th2	20852(Tax:10090)	15111(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY controls|advcl|targeting controls|dobj|development development|amod|END_ENTITY	Grail controls Th2 cell development by targeting STAT6 for degradation .
16547273	0	STAT6	96,101	VCAM-1	26,32	STAT6	VCAM-1	20852(Tax:10090)	22329(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression : involvement of STAT6 .
11254707	0	STAT6	0,5	eotaxin-1	15,24	STAT6	eotaxin-1	6778	6356	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts .
25111027	0	STAT6	49,54	eotaxin-1	20,29	STAT6	eotaxin-1	6778	6356	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway .
16428072	0	STAT6	58,63	eotaxin_1	33,42	STAT6	eotaxin 1	6778	6356	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Glycyrrhizin derivative inhibits eotaxin_1 production via STAT6 in human lung fibroblasts .
18497474	0	STAT6	0,5	interleukin-13	73,87	STAT6	interleukin-13	6778	3596	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	STAT6 mediates apoptosis of human coronary arterial endothelial cells by interleukin-13 .
11572871	0	STAT6	116,121	interleukin-4	55,68	STAT6	interleukin-4	6778	3565	Gene	Gene	site|compound|START_ENTITY transcription|nmod|site transcription|nmod|END_ENTITY	Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site .
12082548	0	STAT6	0,5	interleukin-4	15,28	STAT6	interleukin-4	6778	3565	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inhibition inhibition|compound|END_ENTITY	STAT6 mediates interleukin-4 growth inhibition in human breast_cancer cells .
15199062	0	STAT6	0,5	interleukin-4	74,87	STAT6	interleukin-4	6778	3565	Gene	Gene	form|nsubj|START_ENTITY form|dobj|complex complex|acl:relcl|modulates modulates|nmod|END_ENTITY	STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes .
18625883	0	STAT6	110,115	interleukin-4	96,109	STAT6	interleukin-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	rejection|parataxis|START_ENTITY rejection|nmod|END_ENTITY	Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4 / STAT6 pathway .
18789870	0	STAT6	96,101	interleukin-4	21,34	STAT6	interleukin-4	6778	3565	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|Expression Expression|nmod|END_ENTITY	Expression of canine interleukin-4 in canine chondrocytes inhibits inflammatory cascade through STAT6 .
9786931	0	STAT6	0,5	interleukin-4	56,69	STAT6	interleukin-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages .
26870245	0	STAT6	68,73	miR-135b	0,8	STAT6	miR-135b	6778	442891	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-135b inhibits tumour metastasis in prostate_cancer by targeting STAT6 .
12234934	0	STAT6	44,49	p100	18,22	STAT6	p100	6778	27044	Gene	Gene	coactivator|nmod|START_ENTITY END_ENTITY|nmod|coactivator	Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II .
21762972	0	STAT6	61,66	signal_transducer_and_activator_of_transcription_6	4,54	STAT6	signal transducer and activator of transcription 6	6778	20852(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The signal_transducer_and_activator_of_transcription_6 gene -LRB- STAT6 -RRB- increases the propensity of patients with atopic dermatitis toward disseminated viral skin_infections .
18779571	0	STAT92E	0,7	Drosophila_inhibitor_of_apoptosis_1	35,70	STAT92E	Drosophila inhibitor of apoptosis 1	42428(Tax:7227)	39753(Tax:7227)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	STAT92E is a positive regulator of Drosophila_inhibitor_of_apoptosis_1 -LRB- DIAP/1 -RRB- and protects against radiation-induced apoptosis .
8895396	0	STAT_1_and_3	11,23	leptin_receptor	101,116	STAT 1 and 3	leptin receptor	25124;25125	24536(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Functional STAT_1_and_3 signaling by the leptin_receptor -LRB- OB-R -RRB- ; reduced expression of the rat fatty leptin_receptor in transfected cells .
8895396	0	STAT_1_and_3	11,23	leptin_receptor	41,56	STAT 1 and 3	leptin receptor	25124;25125	24536(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Functional STAT_1_and_3 signaling by the leptin_receptor -LRB- OB-R -RRB- ; reduced expression of the rat fatty leptin_receptor in transfected cells .
21619877	0	STAT_3	45,51	IL-6	18,22	STAT 3	IL-6	6774	3569	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The STAT3 beacon : IL-6 recurrently activates STAT_3 from endosomal structures .
10960361	0	STC-1	46,51	CCK	11,14	STC-1	CCK	6781	885	Gene	Gene	cells|compound|START_ENTITY PACAP|nmod|cells transcription|nmod|PACAP transcription|nsubj|Control Control|nmod|gene gene|compound|END_ENTITY	Control of CCK gene transcription by PACAP in STC-1 cells .
12943684	0	STC-1	4,9	CCK	65,68	STC-1	CCK	6781	885	Gene	Gene	cells|compound|START_ENTITY express|nsubj|cells express|advcl|release release|compound|END_ENTITY	The STC-1 cells express functional orexin-A receptors coupled to CCK release .
17290006	0	STC-1	83,88	CCK	48,51	STC-1	CCK	6781	885	Gene	Gene	cells|compound|START_ENTITY transcription|nmod|cells transcription|compound|END_ENTITY	GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells .
21998136	0	STC-1	94,99	CCK	44,47	STC-1	CCK	6781	885	Gene	Gene	line|appos|START_ENTITY critical|nmod|line critical|nmod|secretion secretion|compound|END_ENTITY	TRPM5 is critical for linoleic_acid-induced CCK secretion from the enteroendocrine cell line , STC-1 .
22648622	0	STC-1	91,96	CCK	58,61	STC-1	CCK	6781	885	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Calcium-sensing_receptor mediates dietary peptide-induced CCK secretion in enteroendocrine STC-1 cells .
24357536	0	STC-1	56,61	CCK	29,32	STC-1	CCK	6781	885	Gene	Gene	cells|compound|START_ENTITY induce|nmod|cells induce|dobj|secretion secretion|compound|END_ENTITY	Unsaturated aldehydes induce CCK secretion via TRPA1 in STC-1 cells .
24759185	0	STC-1	86,91	CCK	47,50	STC-1	CCK	6781	885	Gene	Gene	taste|xcomp|START_ENTITY taste|dobj|ligands ligands|nmod|release release|nmod|END_ENTITY	Effect of five taste ligands on the release of CCK from an enteroendocrine cell line , STC-1 .
9756498	0	STC-1	58,63	CCK	41,44	STC-1	CCK	6781	885	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Inhibition of Na + / H + exchange stimulates CCK secretion in STC-1 cells .
24009869	0	STC-1	67,72	Cholecystokinin	22,37	STC-1	Cholecystokinin	6781	885	Gene	Gene	Cells|compound|START_ENTITY Secretion|nmod|Cells Secretion|compound|END_ENTITY	Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells .
10960361	0	STC-1	46,51	PACAP	37,42	STC-1	PACAP	6781	116	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Control of CCK gene transcription by PACAP in STC-1 cells .
21890837	0	STC-1	106,111	TRPA1	56,61	STC-1	TRPA1	6781	8989	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Green tea polyphenol epigallocatechin_gallate activates TRPA1 in an intestinal enteroendocrine cell line , STC-1 .
7977748	0	STC-1	55,60	bombesin	43,51	STC-1	bombesin	6781	2922	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Regulation of cholecystokinin secretion by bombesin in STC-1 cells .
19896983	0	STC-1	114,119	cholecystokinin	38,53	STC-1	cholecystokinin	6781	885	Gene	Gene	cells|compound|START_ENTITY receptor|nmod|cells secretion|nmod|receptor END_ENTITY|dobj|secretion	Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells .
20352619	0	STC-1	121,126	cholecystokinin	52,67	STC-1	cholecystokinin	6781	885	Gene	Gene	cells|compound|START_ENTITY fatty_acids|nmod|cells fatty_acids|nmod|expression expression|amod|END_ENTITY	Acute and chronic effects of dietary fatty_acids on cholecystokinin expression , storage and secretion in enteroendocrine STC-1 cells .
24741397	0	STC-1	51,56	cholecystokinin	22,37	STC-1	cholecystokinin	6781	885	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Naringenin stimulates cholecystokinin secretion in STC-1 cells .
7488089	0	STC-1	46,51	cholecystokinin	17,32	STC-1	cholecystokinin	20855(Tax:10090)	12424(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Galanin inhibits cholecystokinin secretion in STC-1 cells .
7977748	0	STC-1	55,60	cholecystokinin	14,29	STC-1	cholecystokinin	6781	885	Gene	Gene	cells|compound|START_ENTITY bombesin|nmod|cells secretion|nmod|bombesin secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of cholecystokinin secretion by bombesin in STC-1 cells .
8167157	0	STC-1	97,102	cholecystokinin	35,50	STC-1	cholecystokinin	20855(Tax:10090)	12424(Tax:10090)	Gene	Gene	line|appos|START_ENTITY Characterization|nmod|line Characterization|nmod|release release|nmod|END_ENTITY	Characterization of the release of cholecystokinin from a murine neuroendocrine_tumor cell line , STC-1 .
8216272	0	STC-1	57,62	cholecystokinin	28,43	STC-1	cholecystokinin	6781	885	Gene	Gene	cells|compound|START_ENTITY regulate|nmod|cells regulate|dobj|secretion secretion|compound|END_ENTITY	Potassium channels regulate cholecystokinin secretion in STC-1 cells .
8779970	0	STC-1	94,99	cholecystokinin	26,41	STC-1	cholecystokinin	6781	885	Gene	Gene	cells|compound|START_ENTITY channels|nmod|cells mediated|nmod|channels mediated|nsubjpass|secretion secretion|compound|END_ENTITY	Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells .
8779971	0	STC-1	59,64	cholecystokinin	30,45	STC-1	cholecystokinin	6781	885	Gene	Gene	cells|compound|START_ENTITY regulation|nmod|cells regulation|nmod|secretion secretion|compound|END_ENTITY	Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells .
9048620	0	STC-1	96,101	cholecystokinin	19,34	STC-1	cholecystokinin	81801(Tax:10116)	25298(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Peptones stimulate cholecystokinin secretion and gene transcription in the intestinal cell line STC-1 .
9492022	0	STC-1	86,91	cholecystokinin	14,29	STC-1	cholecystokinin	81801(Tax:10116)	25298(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells .
9782155	0	STC-1	141,146	cholecystokinin	22,37	STC-1	cholecystokinin	6781	885	Gene	Gene	mechanism|nmod|START_ENTITY secretion|dep|mechanism secretion|compound|END_ENTITY	Fatty_acids stimulate cholecystokinin secretion via an acyl chain length-specific , Ca2 + - dependent mechanism in the enteroendocrine cell line STC-1 .
21975601	0	STC1	0,4	PACAP	18,23	STC1	PACAP	81801(Tax:10116)	24166(Tax:10116)	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons .
21139325	0	STC1	58,62	Stanniocalcin-1	41,56	STC1	Stanniocalcin-1	100054071(Tax:9796)	100054071(Tax:9796)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of calcium maintenance factor Stanniocalcin-1 -LRB- STC1 -RRB- by the equine endometrium during the early pregnant period .
9753616	0	STC2	61,65	stanniocalcin	36,49	STC2	stanniocalcin	8614	8614	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Molecular cloning of a second human stanniocalcin homologue -LRB- STC2 -RRB- .
14573615	0	STE11	189,194	STE50	142,147	STE11	STE50	851076(Tax:4932)	850325(Tax:4932)	Gene	Gene	SAM|compound|START_ENTITY kinase|nmod|SAM kinase|dobj|END_ENTITY	Structure of the sterile alpha motif -LRB- SAM -RRB- domain of the Saccharomyces_cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM .
9742096	0	STE11	62,67	STE50	15,20	STE11	STE50	851076(Tax:4932)	850325(Tax:4932)	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase END_ENTITY|nmod|activation	Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated_protein kinase kinase kinase in the high-osmolarity glycerol response pathway .
19177573	0	STE20	36,41	OSR1	42,46	STE20	SPAK	8428	27347	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Crystal structure of domain-swapped STE20 OSR1 kinase domain .
9808774	0	STE20	76,81	mSLK	47,51	STE20	mSLK	223255(Tax:10090)	20874(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Identification and initial characterization of mSLK , a murine member of the STE20 family of kinases .
14573615	0	STE50	142,147	STE11	189,194	STE50	STE11	850325(Tax:4932)	851076(Tax:4932)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|SAM SAM|compound|END_ENTITY	Structure of the sterile alpha motif -LRB- SAM -RRB- domain of the Saccharomyces_cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM .
9742096	0	STE50	15,20	STE11	62,67	STE50	STE11	850325(Tax:4932)	851076(Tax:4932)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated_protein kinase kinase kinase in the high-osmolarity glycerol response pathway .
20304921	0	STEAP4	74,80	six_transmembrane_epithelial_antigen_of_prostate_4	22,72	STEAP4	six transmembrane epithelial antigen of prostate 4	117167(Tax:10090)	117167(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hepatic six_transmembrane_epithelial_antigen_of_prostate_4 -LRB- STEAP4 -RRB- expression by STAT3 and CCAAT/enhancer-binding protein alpha .
21044749	0	STEAP4	66,72	six_transmembrane_epithelial_antigen_of_prostate_4	14,64	STEAP4	six transmembrane epithelial antigen of prostate 4	79689	79689	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variations of six_transmembrane_epithelial_antigen_of_prostate_4 -LRB- STEAP4 -RRB- gene are associated with metabolic_syndrome in a female Uygur general population .
23262293	0	STEAP4	114,120	six_transmembrane_epithelial_antigen_of_prostate_4	62,112	STEAP4	six transmembrane epithelial antigen of prostate 4	117167(Tax:10090)	117167(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional analysis and transcriptional regulation of porcine six_transmembrane_epithelial_antigen_of_prostate_4 -LRB- STEAP4 -RRB- gene and its novel variant in hepatocytes .
21863137	0	STEP	60,64	Striatal-Enriched_Protein_Tyrosine_Phosphatase	12,58	STEP	Striatal-Enriched Protein Tyrosine Phosphatase	84867	84867	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	The Role of Striatal-Enriched_Protein_Tyrosine_Phosphatase -LRB- STEP -RRB- in Cognition .
7490079	0	STEP	75,79	striatum-enriched_phosphatase	44,73	STEP	striatum-enriched phosphatase	84867	84867	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of the human homolog of a striatum-enriched_phosphatase -LRB- STEP -RRB- gene and chromosomal mapping of the human and murine loci .
752593	0	STH	79,82	growth_hormone	63,77	STH	growth hormone	246744	2688	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Animal experiments on the modification of fracture healing by growth_hormone -LRB- STH -RRB- -RSB- .
15670743	0	STI1	20,24	PrP	0,3	STI1	PrP	10963	5621	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	PrP cooperates with STI1 to regulate SOD activity in PrP-deficient neuronal cell line .
22020124	0	STIL	31,35	CPAP	51,55	STIL	CPAP	6491	55835	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation .
23922331	0	STIM1	0,5	CD8	72,75	STIM1	CD8	6786	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	STIM1 and STIM2-mediated Ca -LRB- 2 + -RRB- influx regulates antitumour immunity by CD8 -LRB- + -RRB- T cells .
22565091	0	STIM1	0,5	Ca2	22,25	STIM1	Ca2	6786	760	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|+ +|compound|END_ENTITY	STIM1 is required for Ca2 + signaling during mammalian fertilization .
26546674	0	STIM1	55,60	Calcium_Release-Activated_Calcium_Modulator_1	88,133	STIM1	Calcium Release-Activated Calcium Modulator 1	6786	84876	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
23687376	0	STIM1	19,24	EB1	116,119	STIM1	EB1	6786	22919	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1 .
19433064	0	STIM1	0,5	NADPH_oxidase	70,83	STIM1	NADPH oxidase	6786	1536	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	STIM1 but not STIM2 is an essential regulator of Ca2 + influx-mediated NADPH_oxidase activity in neutrophil-like HL-60 cells .
26546674	0	STIM1	55,60	Stromal_Interaction_Molecule_1	23,53	STIM1	Stromal Interaction Molecule 1	6786	6786	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
23034388	0	STIM1	30,35	TRPC1	0,5	STIM1	TRPC1	20866(Tax:10090)	22063(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	TRPC1 and Orai1 interact with STIM1 and mediate capacitative Ca -LRB- 2 + -RRB- entry caused by acute hypoxia in mouse pulmonary arterial smooth muscle cells .
23625915	0	STIM1	83,88	protease-activated_receptor-1	44,73	STIM1	protease-activated receptor-1	6786	2149	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Store-operated Ca2 + entry -LRB- SOCE -RRB- induced by protease-activated_receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38b mitogen-activated protein kinase .
17689489	0	STIM1	51,56	stromal_interaction_molecule_1	19,49	STIM1	stromal interaction molecule 1	6786	6786	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Functional role of stromal_interaction_molecule_1 -LRB- STIM1 -RRB- in vascular smooth muscle cells .
24114840	0	STIM1	74,79	stromal_interaction_molecule_1	42,72	STIM1	stromal interaction molecule 1	6786	6786	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	17b-Estradiol inhibits phosphorylation of stromal_interaction_molecule_1 -LRB- STIM1 -RRB- protein : implication for store-operated calcium entry and chronic lung_diseases .
26827839	0	STING	54,59	stimulator_of_interferon_gene	23,52	STING	stimulator of interferon gene	533661(Tax:9913)	533661(Tax:9913)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	The function of feline stimulator_of_interferon_gene -LRB- STING -RRB- is evolutionarily conserved .
26237451	0	STIP1_homology_and_U-Box-containing_protein_1	113,158	prion_protein	63,76	STIP1 homology and U-Box-containing protein 1	prion protein	56424;20867	19122(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of novel putative-binding proteins for cellular prion_protein and a specific interaction with the STIP1_homology_and_U-Box-containing_protein_1 .
7507245	0	STK-1	0,5	Flt-3	34,39	STK-1	Flt-3	2322	2322	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	STK-1 , the human homolog of Flk-2 / Flt-3 , is selectively expressed in CD34 + human bone marrow cells and is involved in the proliferation of early progenitor/stem cells .
10353780	0	STK11	32,37	LKB1	26,30	STK11	LKB1	6794	6794	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Germline mutations of the LKB1 -LRB- STK11 -RRB- gene in Peutz-Jeghers patients .
22916036	0	STK11	25,30	Stromal_liver_kinase_B1	0,23	STK11	Stromal liver kinase B1	6794	6794	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Stromal_liver_kinase_B1 -LSB- STK11 -RSB- signaling loss induces oviductal_adenomas and endometrial_cancer by activating mammalian Target of Rapamycin Complex 1 .
16926177	0	STK15	17,22	Aurora-A	24,32	STK15	Aurora-A	6790	6790	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of STK15 -LRB- Aurora-A -RRB- gene and lung_cancer risk in Caucasians .
22652780	0	STK25	22,27	PDCD10	0,6	STK25	PDCD10	10494	11235	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PDCD10 interacts with STK25 to accelerate cell apoptosis under oxidative stress .
7829089	0	STM	43,46	Thermolabile_phenol_sulfotransferase	0,36	STM	Thermolabile phenol sulfotransferase	6818	445329	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Thermolabile_phenol_sulfotransferase gene -LRB- STM -RRB- : localization to human chromosome 16p11 .2 .
7695637	0	STM	49,52	thermolabile_phenol_sulfotransferase	6,42	STM	thermolabile phenol sulfotransferase	6818	445329	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human thermolabile_phenol_sulfotransferase gene -LRB- STM -RRB- : molecular cloning and structural characterization .
12207228	0	STM1	0,4	CDC13	80,85	STM1	CDC13	850843(Tax:4932)	851306(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	STM1 , a gene which encodes a guanine quadruplex binding protein , interacts with CDC13 in Saccharomyces_cerevisiae .
1639418	0	STMY3	39,44	stromelysin_3	24,37	STMY3	stromelysin 3	4320	4320	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human stromelysin_3 -LRB- STMY3 -RRB- gene to the q11 .2 region of chromosome 22 .
19854131	0	STN1	58,62	Conserved_telomere_maintenance_component_1	0,42	STN1	Conserved telomere maintenance component 1	79991	80169	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Conserved_telomere_maintenance_component_1 interacts with STN1 and maintains chromosome ends in higher eukaryotes .
18184564	0	STOPS	21,26	phospholipase_C	84,99	STOPS	phospholipase C	43683(Tax:7227)	31376(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase_C .
25281700	0	STP1	49,53	SUGAR_TRANSPORTER_PROTEIN_1	20,47	STP1	SUGAR TRANSPORTER PROTEIN 1	837667(Tax:3702)	837667(Tax:3702)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Sugar regulation of SUGAR_TRANSPORTER_PROTEIN_1 -LRB- STP1 -RRB- expression in Arabidopsis_thaliana .
8661000	0	STP2	30,34	phenol_sulfotransferase	6,29	STP2	phenol sulfotransferase	6799	6817	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Human phenol_sulfotransferase STP2 gene : molecular cloning , structural characterization , and chromosomal localization .
23688582	0	STR	16,19	CFI	40,43	STR	CFI	6779	3426	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	A hypervariable STR polymorphism in the CFI gene : southern origin of East Asian-specific group H alleles .
24421389	0	STRA6	119,124	STRA6	18,23	STRA6	STRA6	20897(Tax:10090)	20897(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo .
24421389	0	STRA6	18,23	STRA6	119,124	STRA6	STRA6	20897(Tax:10090)	20897(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo .
17339024	0	STRA6	0,5	retinol-binding_protein	35,58	STRA6	retinol-binding protein	64220	5950	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	STRA6 , a cell-surface receptor for retinol-binding_protein : the plot thickens .
12805220	0	STRAD	79,84	LKB1	43,47	STRAD	LKB1	92335	6794	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD .
25485581	0	STRAP	42,47	ASK1	107,111	STRAP	ASK1	20901(Tax:10090)	26408(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A crucial role for the phosphorylation of STRAP at Ser -LRB- 188 -RRB- by MPK38 in STRAP-dependent cell death through ASK1 , TGF-b , p53 , and PI3K/PDK1 signaling pathways .
25485581	0	STRAP	42,47	MPK38	63,68	STRAP	MPK38	20901(Tax:10090)	17279(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A crucial role for the phosphorylation of STRAP at Ser -LRB- 188 -RRB- by MPK38 in STRAP-dependent cell death through ASK1 , TGF-b , p53 , and PI3K/PDK1 signaling pathways .
25483064	0	STRAP	10,15	Sp1	123,126	STRAP	Sp1	20901(Tax:10090)	20683(Tax:10090)	Gene	Gene	START_ENTITY|advcl|modulating modulating|dobj|END_ENTITY	Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21 -LRB- Cip1 -RRB- by modulating the transcription factor Sp1 .
21148321	0	STRAP	80,85	serine-threonine_kinase_receptor-associated_protein	27,78	STRAP	serine-threonine kinase receptor-associated protein	11171	11171	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	B-MYB positively regulates serine-threonine_kinase_receptor-associated_protein -LRB- STRAP -RRB- activity through direct interaction .
22147502	0	STRC	55,59	Stereocilin	42,53	STRC	Stereocilin	161497	161497	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genome-wide SNP genotyping identifies the Stereocilin -LRB- STRC -RRB- gene as a major contributor to pediatric bilateral sensorineural hearing_impairment .
11550090	0	STRICA	0,6	DIAP1	112,117	STRICA	DIAP1	35528(Tax:7227)	39753(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	STRICA , a novel Drosophila_melanogaster caspase with an unusual serine/threonine-rich prodomain , interacts with DIAP1 and DIAP2 .
9223454	0	STRL22	0,6	MIP-3alpha	42,52	STRL22	MIP-3alpha	1235	6364	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	STRL22 is a receptor for the CC chemokine MIP-3alpha .
24173806	0	STRUBBELIG	22,32	QUIRKY	0,6	STRUBBELIG	QUIRKY	837654(Tax:3702)	843811(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	QUIRKY interacts with STRUBBELIG and PAL_OF_QUIRKY to regulate cell growth anisotropy during Arabidopsis gynoecium development .
24948530	0	STS	29,32	Myb14	0,5	STS	Myb14	828186(Tax:3702)	817674(Tax:3702)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Myb14 , a direct activator of STS , is associated with resveratrol content variation in berry skin in two grape cultivars .
7909532	0	STS	14,17	dystrophin	38,48	STS	dystrophin	412	1756	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	A polymorphic STS in intron 44 of the dystrophin gene .
2767285	0	STS	33,36	steroid_sulfatase	14,31	STS	steroid sulfatase	412	412	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Study on the steroid_sulfatase -LRB- STS -RRB- activity in normal individuals and patients with abnormal sexual differentiation -RSB- .
23530066	0	STT3B	71,76	OST	92,95	STT3B	OST	201595	1650	Gene	Gene	isoform|compound|START_ENTITY isoform|nmod|END_ENTITY	Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST .
8702635	0	STX	37,40	ST8Sia_II	26,35	STX	ST8Sia II	20450(Tax:10090)	20450(Tax:10090)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of mouse ST8Sia_II -LRB- STX -RRB- as a neural_cell_adhesion_molecule-specific polysialic_acid synthase .
26709266	0	STX11	26,31	Syntaxin_11	8,19	STX11	Syntaxin 11	8676	8676	Gene	Gene	Mutation|appos|START_ENTITY Mutation|compound|END_ENTITY	A Novel Syntaxin_11 Gene -LRB- STX11 -RRB- Mutation c. 650T > C , p.Leu217Pro , in a Korean Child With Familial_Hemophagocytic_Lymphohistiocytosis .
19967551	0	STX11	24,29	syntaxin_11	6,17	STX11	syntaxin 11	8676	8676	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel syntaxin_11 gene -LRB- STX11 -RRB- mutation in three Argentinean patients with hemophagocytic_lymphohistiocytosis .
17912268	0	STX1A	48,53	SYNTAXIN_1A	35,46	STX1A	SYNTAXIN 1A	6804	6804	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Search for genetic variants of the SYNTAXIN_1A -LRB- STX1A -RRB- gene : the -352 _ A > T variant in the STX1A promoter associates with impaired_glucose_metabolism in an Italian obese population .
9177791	0	STX1A	45,50	syntaxin_1A	27,38	STX1A	syntaxin 1A	6804	6804	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the human HPC-1 / syntaxin_1A gene -LRB- STX1A -RRB- to chromosome 7 band q11 .2 .
9763659	0	STX1A	51,56	syntaxin_1A	33,44	STX1A	syntaxin 1A	6804	6804	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hemizygous deletion of the HPC-1 / syntaxin_1A gene -LRB- STX1A -RRB- in patients with Williams_syndrome .
19055941	0	SUFU	46,50	Hedgehog	54,62	SUFU	Hedgehog	51684	42737(Tax:7227)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Role and regulation of human tumor suppressor SUFU in Hedgehog signaling .
9551090	0	SUG1	108,112	Phosducin-like_protein	0,22	SUG1	Phosducin-like protein	19184(Tax:10090)	67466(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Phosducin-like_protein -LRB- PhLP -RRB- , a regulator of G beta gamma function , interacts with the proteasomal protein SUG1 .
9738875	0	SUG1	55,59	Pros45	32,38	SUG1	Pros45	33105(Tax:7227)	33105(Tax:7227)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Cloning and characterization of Pros45 , the Drosophila SUG1 proteasome subunit homolog .
25281700	0	SUGAR_TRANSPORTER_PROTEIN_1	20,47	STP1	49,53	SUGAR TRANSPORTER PROTEIN 1	STP1	837667(Tax:3702)	837667(Tax:3702)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Sugar regulation of SUGAR_TRANSPORTER_PROTEIN_1 -LRB- STP1 -RRB- expression in Arabidopsis_thaliana .
17720696	0	SULF1	0,5	GDNF	50,54	SULF1	GDNF	240725(Tax:10090)	14573(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation .
19373441	0	SULF1	52,57	sulfatase_1	39,50	SULF1	sulfatase 1	23213	23213	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	The tumor suppressor function of human sulfatase_1 -LRB- SULF1 -RRB- in carcinogenesis .
22293178	0	SULF2	26,31	PDGFRa	42,48	SULF2	PDGFRa	55959	5156	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	Heparan sulfate sulfatase SULF2 regulates PDGFRa signaling and growth in human and mouse malignant_glioma .
15122594	0	SULT1A1	10,17	CYP1B1	19,25	SULT1A1	CYP1B1	6817	1545	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|nummod|END_ENTITY	GST , NAT , SULT1A1 , CYP1B1 genetic polymorphisms , interactions with environmental exposures and bladder_cancer risk in a high-risk population .
21791872	0	SULT1A1	92,99	CYP2A13	75,82	SULT1A1	CYP2A13	6817	1553	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
21791872	0	SULT1A1	92,99	CYP2A6	67,73	SULT1A1	CYP2A6	6817	1548	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
21791872	0	SULT1A1	92,99	CYP4B1	84,90	SULT1A1	CYP4B1	6817	1580	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association between cancer risk and drug-metabolizing enzyme gene -LRB- CYP2A6 , CYP2A13 , CYP4B1 , SULT1A1 , GSTM1 , and GSTT1 -RRB- polymorphisms in cases of lung_cancer in Japan .
14643027	0	SULT1A1	22,29	Sulfotransferase_1A1	0,20	SULT1A1	Sulfotransferase 1A1	6817	6817	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Sulfotransferase_1A1 -LRB- SULT1A1 -RRB- polymorphism and bladder_cancer risk : a case-control study .
15093672	0	SULT1A1	22,29	Sulfotransferase_1A1	0,20	SULT1A1	Sulfotransferase 1A1	6817	6817	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Sulfotransferase_1A1 -LRB- SULT1A1 -RRB- polymorphism and breast_cancer risk in Chinese women .
17963788	0	SULT1A3	41,48	sulfotransferase_1A3	19,39	SULT1A3	sulfotransferase 1A3	6818	6818	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of human sulfotransferase_1A3 -LRB- SULT1A3 -RRB- by glucocorticoids .
15878968	0	SULT2A1	71,78	estrogen-related_receptor_alpha	83,114	SULT2A1	estrogen-related receptor alpha	6822	2101	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- by estrogen-related_receptor_alpha .
18684447	0	SULT2A1	79,86	insulin	10,17	SULT2A1	insulin	6822	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin and testosterone on androgen production and transcription of SULT2A1 in the NCI-H295R adrenocortical cell line .
15878968	0	SULT2A1	71,78	sulfotransferase	53,69	SULT2A1	sulfotransferase	6822	6822	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- by estrogen-related_receptor_alpha .
23436881	0	SULT2A1	59,66	sulfotransferase	42,58	SULT2A1	sulfotransferase	6822	6822	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Relationship between polymorphisms in the sulfotransferase SULT2A1 gene and dehydroepiandrosterone_sulfate concentration in children .
19420132	0	SULT2A1	40,47	sulfotransferase_2A1	18,38	SULT2A1	sulfotransferase 2A1	6822	6822	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Selective role of sulfotransferase_2A1 -LRB- SULT2A1 -RRB- in the N-sulfoconjugation of quinolone drugs in humans .
11735126	0	SUMO-1	54,60	Dnmt3b	0,6	SUMO-1	Dnmt3b	7341	1789	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dnmt3b , de novo DNA methyltransferase , interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1 .
21931855	0	SUMO-1	8,14	Nkx2-5	58,64	SUMO-1	Nkx2-5	7341	1482	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5 .
17360386	0	SUMO-1	39,45	PML	24,27	SUMO-1	PML	7341	5371	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid_arthritis synovial fibroblasts .
11854305	0	SUMO-1	0,6	RanGAP1	15,22	SUMO-1	RanGAP1	7341	5905	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles .
15707587	0	SUMO-1	0,6	SNURF	31,36	SUMO-1	SNURF	7341	8926	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|association association|nmod|END_ENTITY	SUMO-1 promotes association of SNURF -LRB- RNF4 -RRB- with PML nuclear bodies .
10364461	0	SUMO-1	8,14	Smt3	0,4	SUMO-1	Smt3	7341	852122(Tax:4932)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Smt3 , a SUMO-1 homolog , is conjugated to Cdc3 , a component of septin rings at the mother-bud neck in budding yeast .
15569683	0	SUMO-1	12,18	TDG	64,67	SUMO-1	TDG	7341	6996	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Noncovalent SUMO-1 binding activity of thymine_DNA_glycosylase -LRB- TDG -RRB- is required for its SUMO-1 modification and colocalization with the promyelocytic_leukemia_protein .
12813045	0	SUMO-1	0,6	Ubc9	7,11	SUMO-1	Ubc9	7341	7329	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	SUMO-1 / Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4 .
21308649	0	SUMO-1	0,6	ataxin-1	29,37	SUMO-1	ataxin-1	22218(Tax:10090)	20238(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SUMO-1 interacts with mutant ataxin-1 and colocalizes to its aggregates in Purkinje cells of SCA1 transgenic_mice .
22586270	0	SUMO-1	43,49	estrogen_receptor_b	18,37	SUMO-1	estrogen receptor b	7341	2100	Gene	Gene	target|compound|START_ENTITY END_ENTITY|nmod|target	Identification of estrogen_receptor_b as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen_synthase_kinase_3b .
10562558	0	SUMO-1	63,69	p53	14,17	SUMO-1	p53	7341	7157	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1 .
15569683	0	SUMO-1	12,18	thymine_DNA_glycosylase	39,62	SUMO-1	thymine DNA glycosylase	7341	6996	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Noncovalent SUMO-1 binding activity of thymine_DNA_glycosylase -LRB- TDG -RRB- is required for its SUMO-1 modification and colocalization with the promyelocytic_leukemia_protein .
15569683	0	SUMO-1	89,95	thymine_DNA_glycosylase	39,62	SUMO-1	thymine DNA glycosylase	7341	6996	Gene	Gene	modification|compound|START_ENTITY required|nmod|modification required|nsubjpass|activity activity|nmod|END_ENTITY	Noncovalent SUMO-1 binding activity of thymine_DNA_glycosylase -LRB- TDG -RRB- is required for its SUMO-1 modification and colocalization with the promyelocytic_leukemia_protein .
19597476	0	SUMO-2	37,43	Heat_shock_protein_27	0,21	SUMO-2	Heat shock protein 27	6613	3315	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Heat_shock_protein_27 is involved in SUMO-2 / 3 modification of heat_shock factor 1 and thereby modulates the transcription factor activity .
16567619	0	SUMO-2	23,29	NXP-2	0,5	SUMO-2	NXP-2	6613	23515	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression .
23417988	0	SUMO-2	74,80	matrixmetalloproteinase-3_and_matrixmetalloproteinase-13	14,70	SUMO-2	matrixmetalloproteinase-3 and matrixmetalloproteinase-13	6613	4322	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of matrixmetalloproteinase-3_and_matrixmetalloproteinase-13 by SUMO-2 / 3 through the transcription factor NF-kB .
21900752	0	SUMO-2	14,20	p53	39,42	SUMO-2	p53	170930(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|dep|modification modification|nmod|END_ENTITY	MDM2 promotes SUMO-2 / 3 modification of p53 to modulate transcriptional activity .
18842587	0	SUMO-3	130,136	MBD1-containing_chromatin-associated_factor_1	75,120	SUMO-3	MBD1-containing chromatin-associated factor 1	6612	55729	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Structure of the small ubiquitin-like modifier -LRB- SUMO -RRB- - interacting motif of MBD1-containing_chromatin-associated_factor_1 bound to SUMO-3 .
16361251	0	SUMO-3	0,6	androgen_receptor	16,33	SUMO-3	androgen receptor	6612	367	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	SUMO-3 enhances androgen_receptor transcriptional activity through a sumoylation-independent mechanism in prostate_cancer cells .
23770046	0	SUMO1	0,5	EVI1	59,63	SUMO1	EVI1	7341	2122	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	SUMO1 negatively regulates the transcriptional activity of EVI1 and significantly increases its co-localization with EVI1 after treatment with arsenic_trioxide .
21683690	0	SUMO1	0,5	NADPH_oxidase_2	61,76	SUMO1	NADPH oxidase 2	7341	1536	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH_oxidase_2 .
16648470	0	SUN1	0,4	lamin_A	28,35	SUN1	lamin A	23353	4000	Gene	Gene	interacts|nummod|START_ENTITY interacts|nmod|END_ENTITY	SUN1 interacts with nuclear lamin_A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton .
9428412	0	SUP-17	0,6	ADAM	33,37	SUP-17	ADAM	172689(Tax:6239)	36037(Tax:7227)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	SUP-17 , a Caenorhabditis_elegans ADAM protein related to Drosophila KUZBANIAN , and its role in LIN-12 / NOTCH signalling .
9428412	0	SUP-17	0,6	NOTCH	102,107	SUP-17	NOTCH	172689(Tax:6239)	31293(Tax:7227)	Gene	Gene	START_ENTITY|parataxis|signalling signalling|nsubj|END_ENTITY	SUP-17 , a Caenorhabditis_elegans ADAM protein related to Drosophila KUZBANIAN , and its role in LIN-12 / NOTCH signalling .
2080663	0	SUP2	31,35	SUP35	37,42	SUP2	SUP35	851828(Tax:4932)	851752(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Divergence and conservation of SUP2 -LRB- SUP35 -RRB- gene of yeast Pichia pinus and Saccharomyces_cerevisiae .
3047009	0	SUP2	27,31	SUP35	33,38	SUP2	SUP35	851828(Tax:4932)	851752(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Nucleotide sequence of the SUP2 -LRB- SUP35 -RRB- gene of Saccharomyces_cerevisiae .
2080663	0	SUP35	37,42	SUP2	31,35	SUP35	SUP2	851752(Tax:4932)	851828(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Divergence and conservation of SUP2 -LRB- SUP35 -RRB- gene of yeast Pichia pinus and Saccharomyces_cerevisiae .
3047009	0	SUP35	33,38	SUP2	27,31	SUP35	SUP2	851752(Tax:4932)	851828(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Nucleotide sequence of the SUP2 -LRB- SUP35 -RRB- gene of Saccharomyces_cerevisiae .
1474892	0	SUP45	41,46	SAL4	35,39	SUP45	SAL4	852440(Tax:4932)	852440(Tax:4932)	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Ribosomal association of the yeast SAL4 -LRB- SUP45 -RRB- gene product : implications for its role in translation fidelity and termination .
7586027	0	SUP45	23,28	SAL4	30,34	SUP45	SAL4	852440(Tax:4932)	852440(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A mutant allele of the SUP45 -LRB- SAL4 -RRB- gene of Saccharomyces_cerevisiae shows temperature-dependent allosuppressor and omnipotent suppressor phenotypes .
15262279	0	SUR	43,46	sulfonylurea_receptor	20,41	SUR	sulfonylurea receptor	34350(Tax:7227)	34350(Tax:7227)	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Significance of the sulfonylurea_receptor -LRB- SUR -RRB- as the target of diflubenzuron in chitin synthesis inhibition in Drosophila_melanogaster and Blattella_germanica .
8635661	0	SUR	48,51	sulfonylurea_receptor	25,46	SUR	sulfonylurea receptor	6833	6833	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence variants in the sulfonylurea_receptor -LRB- SUR -RRB- gene are associated with NIDDM in Caucasians .
9851882	0	SUR	152,155	sulfonylurea_receptor	129,150	SUR	sulfonylurea receptor	6833	6833	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea_receptor -LRB- SUR -RRB- gene .
9671465	0	SUR-5	23,28	LET-60	82,88	SUR-5	LET-60	180992(Tax:6239)	178104(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Caenorhabditis_elegans SUR-5 , a novel but conserved protein , negatively regulates LET-60 Ras activity during vulval induction .
21992908	0	SUR1	57,61	ABCC8	50,55	SUR1	ABCC8	6833	6833	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Congenital_hyperinsulinism caused by mutations in ABCC8 -LRB- SUR1 -RRB- gene .
22291026	0	SUR1	95,99	TRPM4	63,68	SUR1	TRPM4	6833	54795	Gene	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	On potential interactions between non-selective cation channel TRPM4 and sulfonylurea receptor SUR1 .
9769320	0	SUR1	48,52	sulfonylurea_receptor	25,46	SUR1	sulfonylurea receptor	6833	6833	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Paternal mutation of the sulfonylurea_receptor -LRB- SUR1 -RRB- gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous_hyperplasia .
11030411	0	SUR1	68,72	sulfonylurea_receptor_1	43,66	SUR1	sulfonylurea receptor 1	6833	6833	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of a variant in exon 31 of the sulfonylurea_receptor_1 -LRB- SUR1 -RRB- gene with type_2_diabetes_mellitus in French Caucasians .
12149601	0	SUR1	61,65	sulfonylurea_receptor_1	36,59	SUR1	sulfonylurea receptor 1	6833	6833	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic variation in exon 18 of the sulfonylurea_receptor_1 -LRB- SUR1 -RRB- gene , insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects .
25576887	0	SUR2A	48,53	Akt	66,69	SUR2A	Akt	20928(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Mild hypoxia in vivo regulates cardioprotective SUR2A : A role for Akt and LDH .
23131994	0	SUSD2	49,54	sushi_domain_containing_2	22,47	SUSD2	sushi domain containing 2	71733(Tax:10090)	71733(Tax:10090)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Multiple functions of sushi_domain_containing_2 -LRB- SUSD2 -RRB- in breast tumorigenesis .
26480818	0	SUSD4	66,71	Sushi_Domain-Containing_Protein_4	31,64	SUSD4	Sushi Domain-Containing Protein 4	55061	55061	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The human complement inhibitor Sushi_Domain-Containing_Protein_4 -LRB- SUSD4 -RRB- expression in tumor cells and infiltrating T cells is associated with better prognosis of breast_cancer patients .
11401714	0	SUT1p	0,5	Cyc8p	23,28	SUT1p	Cyc8p	852714(Tax:4932)	852410(Tax:4932)	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	SUT1p interaction with Cyc8p -LRB- Ssn6p -RRB- relieves hypoxic genes from Cyc8p-Tup1p repression in Saccharomyces_cerevisiae .
23149855	0	SUUR	11,15	PCNA	40,44	SUUR	PCNA	45739(Tax:7227)	37290(Tax:7227)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Drosophila SUUR protein associates with PCNA and binds chromatin in a cell cycle-dependent manner .
12917624	0	SUV39H1	0,7	AML1	23,27	SUV39H1	AML1	6839	861	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SUV39H1 interacts with AML1 and abrogates AML1 transactivity .
18655152	0	SUV39H1	44,51	EVI1	0,4	SUV39H1	EVI1	6839	2122	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	EVI1 recruits the histone_methyltransferase SUV39H1 for transcription repression .
23386123	0	SUV39H1	69,76	LEDGF	25,30	SUV39H1	LEDGF	6839	11168	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island .
18004385	0	SUV39H1	47,54	SIRT1	0,5	SUV39H1	SIRT1	6839	23411	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation .
16409643	0	SUV39H1	0,7	Tax	30,33	SUV39H1	Tax	6839	1491938(Tax:11908)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR .
25672609	0	SUZ12	0,5	KLF2	78,82	SUZ12	KLF2	23512	10365	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	SUZ12 promotes gastric_cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin .
16712789	0	SUZ12	30,35	MEP50	59,64	SUZ12	MEP50	23512	79084	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro .
20801538	0	SV2	4,7	KLF6	19,23	SV2	KLF6	9900	1316	Gene	Gene	variant|compound|START_ENTITY variant|nmod|END_ENTITY	The SV2 variant of KLF6 is down-regulated in hepatocellular_carcinoma and displays anti-proliferative and pro-apoptotic functions .
11748641	0	SV2	42,45	synaptic_vesicle_protein_2	14,40	SV2	synaptic vesicle protein 2	9900	9900	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of synaptic_vesicle_protein_2 -LRB- SV2 -RRB- in neuroendocrine_tumours of the gastrointestinal tract and pancreas .
19751703	0	SV2A	70,74	synaptic_vesicle_protein_2A	41,68	SV2A	synaptic vesicle protein 2A	64051(Tax:10090)	64051(Tax:10090)	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Preferential increase in the hippocampal synaptic_vesicle_protein_2A -LRB- SV2A -RRB- by pentylenetetrazole kindling .
15466855	0	SV2B	0,4	synaptotagmin_1	15,30	SV2B	synaptotagmin 1	64176(Tax:10090)	20979(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SV2B regulates synaptotagmin_1 by direct interaction .
21347255	0	SVCT2	42,47	Sodium-dependent_vitamin_C_transporter_2	0,40	SVCT2	Sodium-dependent vitamin C transporter 2	54338(Tax:10090)	54338(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sodium-dependent_vitamin_C_transporter_2 -LRB- SVCT2 -RRB- expression and activity in brain capillary endothelial cells after transient ischemia in mice .
23321552	0	SVCT2	71,76	gulo	61,65	SVCT2	gulo	54338(Tax:10090)	268756(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Combined vitamin_C and E deficiency induces motor_defects in gulo -LRB- - / - -RRB- / SVCT2 -LRB- + / - -RRB- mice .
17566572	0	SVP	44,47	SHORT_VEGETATIVE_PHASE	20,42	SVP	SHORT VEGETATIVE PHASE	816787(Tax:3702)	816787(Tax:3702)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A conserved role of SHORT_VEGETATIVE_PHASE -LRB- SVP -RRB- in controlling flowering time of Brassica plants .
22659182	0	SVP	24,27	SHORT_VEGETATIVE_PHASE	0,22	SVP	SHORT VEGETATIVE PHASE	816787(Tax:3702)	816787(Tax:3702)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	SHORT_VEGETATIVE_PHASE -LRB- SVP -RRB- protein negatively regulates miR172 transcription via direct binding to the pri-miR172a promoter in Arabidopsis .
18753612	0	SVS2	51,55	GM1	12,15	SVS2	GM1	53878(Tax:10090)	210582(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Ganglioside GM1 mediates decapacitation effects of SVS2 on murine spermatozoa .
20865124	0	SWAN-1	11,17	EGL-9	27,32	SWAN-1	EGL-9	179876(Tax:6239)	179461(Tax:6239)	Gene	Gene	Binds|compound|START_ENTITY Binds|nmod|END_ENTITY	C. _ elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas_aeruginosa PAO1 .
21728176	0	SWAP-70	35,42	IRF-4	15,20	SWAP-70	IRF-4	20947(Tax:10090)	16364(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Fine tuning of IRF-4 expression by SWAP-70 controls the initiation of plasma cell development .
21421853	0	SWAP-70	92,99	RhoA	108,112	SWAP-70	RhoA	20947(Tax:10090)	11848(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Sphingosine_1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA .
15454538	0	SWI/SNF	84,91	Brahma	76,82	SWI/SNF	Brahma	31120;31442	39744(Tax:7227)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	SNR1 -LRB- INI1/SNF5 -RRB- mediates important cell growth functions of the Drosophila Brahma -LRB- SWI/SNF -RRB- chromatin remodeling complex .
14682613	0	SWI3	22,26	CHB2	0,4	SWI3	CHB2	853264(Tax:4932)	817927(Tax:3702)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	CHB2 , a member of the SWI3 gene family , is a global regulator in Arabidopsis .
11604513	0	SWI3	31,35	Srg3	0,4	SWI3	Srg3	853264(Tax:4932)	20588(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Srg3 , a mouse homolog of yeast SWI3 , is essential for early embryogenesis and involved in brain development .
22670862	0	SYCP3	66,71	synaptonemal_complex_protein_3	34,64	SYCP3	synaptonemal complex protein 3	50511	50511	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Investigation of mutations in the synaptonemal_complex_protein_3 -LRB- SYCP3 -RRB- gene among azoospermic infertile male patients in the Turkish population .
24485456	0	SYG-1	34,39	SYG-2	40,45	SYG-1	SYG-2	180555(Tax:6239)	181561(Tax:6239)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Extracellular architecture of the SYG-1 / SYG-2 adhesion complex instructs synaptogenesis .
24485456	0	SYG-2	40,45	SYG-1	34,39	SYG-2	SYG-1	181561(Tax:6239)	180555(Tax:6239)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Extracellular architecture of the SYG-1 / SYG-2 adhesion complex instructs synaptogenesis .
24525236	0	SYK	0,3	FLT3	31,35	SYK	FLT3	6850	2322	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	SYK is a critical regulator of FLT3 in acute_myeloid_leukemia .
25531330	0	SYK	0,3	ITGb4	21,26	SYK	ITGb4	6850	3691	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	SYK interaction with ITGb4 suppressed by Epstein-Barr_virus LMP2A modulates migration and invasion of nasopharyngeal_carcinoma cells .
23293025	0	SYK	61,64	ITK	17,20	SYK	ITK	6850	3702	Gene	Gene	Signaling|dep|START_ENTITY Signaling|nmod|END_ENTITY	Signaling of the ITK -LRB- interleukin 2-inducible T cell kinase -RRB- - SYK -LRB- spleen tyrosine kinase -RRB- fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70 .
25946330	0	SYK	0,3	MHC-II	25,31	SYK	MHC-II	20963(Tax:10090)	111364(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL .
25946330	0	SYK	0,3	MHC-II	25,31	SYK	MHC-II	20963(Tax:10090)	111364(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL .
23535559	0	SYK	0,3	mTOR	14,18	SYK	mTOR	6850	21977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	SYK regulates mTOR signaling in AML .
23250796	0	SYN1	73,77	synapsin_I	56,66	SYN1	synapsin I	20964(Tax:10090)	20964(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Specificity_protein_1 -LRB- Sp1 -RRB- - dependent activation of the synapsin_I gene -LRB- SYN1 -RRB- is modulated by RE1-silencing_transcription_factor -LRB- REST -RRB- and 5 ' - cytosine-phosphoguanine -LRB- CpG -RRB- methylation .
7587399	0	SYN2	24,28	synapsin_II	11,22	SYN2	synapsin II	6854	6854	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Mapping of synapsin_II -LRB- SYN2 -RRB- genes to human chromosome 3p and mouse chromosome 6 band F. Synapsins are neuron-specific phosphoproteins of small synaptic vesicles encoded by two different genes .
24312498	0	SYNAPSIN_I	26,36	PRICKLE1	0,8	SYNAPSIN I	PRICKLE1	20964(Tax:10090)	106042(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	PRICKLE1 interaction with SYNAPSIN_I reveals a role in autism_spectrum_disorders .
17912268	0	SYNTAXIN_1A	35,46	STX1A	48,53	SYNTAXIN 1A	STX1A	6804	6804	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Search for genetic variants of the SYNTAXIN_1A -LRB- STX1A -RRB- gene : the -352 _ A > T variant in the STX1A promoter associates with impaired_glucose_metabolism in an Italian obese population .
11423977	0	SYT	40,43	AF10	97,101	SYT	AF10	6760	8028	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The synovial_sarcoma associated protein SYT interacts with the acute_leukemia_associated_protein AF10 .
16227627	0	SYT	22,25	EWS	157,160	SYT	EWS	6857	2130	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator -LRB- SIP/CoAA -RRB- , a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins .
15467731	0	SYT	0,3	mSin3A	75,81	SYT	mSin3A	6857	20466(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SYT , a partner of SYT-SSX oncoprotein in synovial_sarcomas , interacts with mSin3A , a component of histone deacetylase complex .
22490392	0	SZP	39,42	superficial_zone_protein	13,37	SZP	superficial zone protein	10216	10216	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of superficial_zone_protein -LRB- SZP -RRB- / lubricin/PRG _ 4 in muscle-derived mesenchymal stem/progenitor cells by transforming_growth_factor-b1 and bone_morphogenetic_protein-7 .
16425372	0	S_phase_kinase-associated_protein_2	30,65	p27	93,96	S phase kinase-associated protein 2	p27	6502	10671	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Relation of overexpression of S_phase_kinase-associated_protein_2 with reduced expression of p27 and PTEN in human gastric_carcinoma .
10101157	0	Sac6p	32,37	fimbrin	23,30	Sac6p	fimbrin	851707(Tax:4932)	851707(Tax:4932)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Suppressor analysis of fimbrin -LRB- Sac6p -RRB- overexpression in yeast .
15121837	0	Sae2	31,35	Mec1	71,75	Sae2	Mec1	852700(Tax:4932)	852433(Tax:4932)	Gene	Gene	functions|nmod|START_ENTITY require|nsubj|functions require|dobj|phosphorylation phosphorylation|amod|END_ENTITY	The functions of budding yeast Sae2 in the DNA damage response require Mec1 - and Tel1-dependent phosphorylation .
16861895	0	Sae2	14,18	Mec1	47,51	Sae2	Mec1	852700(Tax:4932)	852433(Tax:4932)	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis .
24389104	0	Saf1	44,48	SCF	40,43	Saf1	SCF	4150	4254	Gene	Gene	pathway|appos|START_ENTITY pathway|compound|END_ENTITY	Ubiquitin ligase trapping identifies an SCF -LRB- Saf1 -RRB- pathway targeting unprocessed vacuolar/lysosomal proteins .
16186110	0	Saitohin	0,8	peroxiredoxin_6	140,155	Saitohin	peroxiredoxin 6	246744	9588	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Saitohin , which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative_diseases , interacts with peroxiredoxin_6 .
23954296	0	Sal-like_4	0,10	CDH1	30,34	Sal-like 4	CDH1	57167	999	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Sal-like_4 -LRB- SALL4 -RRB- suppresses CDH1 expression and maintains cell dispersion in basal-like breast_cancer .
25580951	0	Sal-like_protein_2	0,18	p16	31,34	Sal-like protein 2	p16	6297	1029	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Sal-like_protein_2 upregulates p16 expression through a proximal promoter element .
21062744	0	Sall1	0,5	nanog	72,77	Sall1	nanog	6299	79923	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Sall1 regulates embryonic stem cell differentiation in association with nanog .
26567857	0	Salt-Inducible_Kinase_1	16,39	SIK1	41,45	Salt-Inducible Kinase 1	SIK1	150094	150094	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	A Novel Role of Salt-Inducible_Kinase_1 -LRB- SIK1 -RRB- in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity .
22522110	0	Salt-inducible_kinase_1	0,23	E-cadherin	34,44	Salt-inducible kinase 1	E-cadherin	17691(Tax:10090)	12550(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Salt-inducible_kinase_1 regulates E-cadherin expression and intercellular junction stability .
25384047	0	Salt-inducible_kinase_1	0,23	gastrin	45,52	Salt-inducible kinase 1	gastrin	150094	2520	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Salt-inducible_kinase_1 -LRB- SIK1 -RRB- is induced by gastrin and inhibits migration of gastric_adenocarcinoma cells .
25792973	0	Salt-inducible_kinase_2	24,47	B55gamma	112,120	Salt-inducible kinase 2	B55gamma	23235	5522	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association between Salt-inducible_kinase_2 -LRB- SIK2 -RRB- and gamma isoform of the regulatory subunit B55 of PP2A -LRB- B55gamma -RRB- contributes to the survival of glioma cells under glucose depletion through inhibiting the phosphorylation of S6K .
16697365	0	Salusin_beta	0,12	MrgA1	78,83	Salusin beta	MrgA1	27433	233221(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Salusin_beta is a surrogate ligand of the mas-like G protein-coupled receptor MrgA1 .
12496368	0	Sam68	103,108	CBP	73,76	Sam68	CBP	10657	1387	Gene	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68 .
22005517	0	Sam68	0,5	IRS1	21,25	Sam68	IRS1	10657	3667	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sam68 interacts with IRS1 .
26136151	0	Sam68	78,83	MicroRNA-203	0,12	Sam68	MicroRNA-203	10657	406986	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68 .
15184885	0	Sam68	29,34	RACK1	0,5	Sam68	RACK1	20218(Tax:10090)	14694(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RACK1 regulates Src-mediated Sam68 and p190RhoGAP signaling .
10913193	0	Sam68	25,30	Sik	0,3	Sam68	Sik	10657	150094	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Sik -LRB- BRK -RRB- phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability .
9315091	0	Sam68	37,42	Src	23,26	Sam68	Src	10657	6714	Gene	Gene	substrate|dobj|START_ENTITY substrate|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis .
21672929	0	Sam68	0,5	leptin_receptor	54,69	Sam68	leptin receptor	10657	3953	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Sam68 mediates leptin-stimulated growth by modulating leptin_receptor signaling in human trophoblastic JEG-3 cells .
9743338	0	Sam68	0,5	p120GAP	23,30	Sam68	p120GAP	20218(Tax:10090)	5921	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Sam68 association with p120GAP in CD4 + T cells is dependent on CD4 molecule expression .
15901829	0	Sanpodo	39,46	lethal_giant_larvae	50,69	Sanpodo	lethal giant larvae	318559(Tax:7227)	33156(Tax:7227)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Regulation of membrane localization of Sanpodo by lethal_giant_larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs .
6751836	0	Sar1	45,49	angiotensin_II	16,30	Sar1	angiotensin II	56681	183	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Effect of three angiotensin_II antagonists , -LSB- Sar1 , Thr8 -RSB- - , -LSB- Sar1 , Ile8 -RSB- - and -LSB- Sar1 , Ala8 -RSB- angiotensin_II on blood pressure and endocrine factors in normal subjects .
12134149	0	Sara	10,14	PP1	0,3	Sara	PP1	44263(Tax:7227)	49260(Tax:7227)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	PP1 binds Sara and negatively regulates Dpp signaling in Drosophila_melanogaster .
9575189	0	Sarcolipin	0,10	SERCA1	37,43	Sarcolipin	SERCA1	100009246(Tax:9986)	100037716(Tax:9986)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Sarcolipin regulates the activity of SERCA1 , the fast-twitch skeletal muscle sarcoplasmic reticulum Ca2 + - ATPase .
12626510	0	Sas2	73,77	Sas4	0,4	Sas2	Sas4	855157(Tax:4932)	851762(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex .
12077334	0	Sas3p	32,37	Yng1p	0,5	Sas3p	Yng1p	852228(Tax:4932)	854230(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex .
12626510	0	Sas4	0,4	Sas2	73,77	Sas4	Sas2	851762(Tax:4932)	855157(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex .
21930775	0	Satb1	14,19	p63	0,3	Satb1	p63	20230(Tax:10090)	22061(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis .
21828043	0	Satb2	83,88	Osterix	41,48	Satb2	Osterix	212712(Tax:10090)	170574(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- is an upstream regulator of Satb2 during bone formation .
22334647	0	Satb2	66,71	Ski	14,17	Satb2	Ski	23314	6497	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons .
12432081	0	Sbh1p	0,5	calnexin	71,79	Sbh1p	calnexin	856821(Tax:4932)	851241(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sbh1p , a subunit of the Sec61 translocon , interacts with the chaperone calnexin in the yeast Yarrowia_lipolytica .
22985412	0	ScN2a	90,95	prion_protein	73,86	ScN2a	prion protein	6326	5621	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Cytochalasin D enhances the accumulation of a protease-resistant form of prion_protein in ScN2a cells : involvement of PI3 kinase/Akt signalling pathway .
10729991	0	Sca-1	51,56	C-Kit	59,64	Sca-1	C-Kit	110454(Tax:10090)	16590(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|appos|END_ENTITY	Thrombopoietin stimulates murine lineage negative , Sca-1 + , C-Kit + , CD34 - cells : comparative study with stem_cell_factor or interleukin-3 .
24919180	0	Sca-1	68,73	CD31	75,79	Sca-1	CD31	20238(Tax:10090)	18613(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|dep|END_ENTITY	Intra-myocardial injection of both growth factors and heart derived Sca-1 + / CD31 - cells attenuates post-MI LV remodeling more than does cell transplantation alone : neither intervention enhances functionally significant cardiomyocyte regeneration .
10634171	0	Sca-1	98,103	CD34	91,95	Sca-1	CD34	110454(Tax:10090)	12490(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ END_ENTITY|dep|+	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
21527748	0	Sca-1	95,100	Flk-1	88,93	Sca-1	Flk-1	110454(Tax:10090)	16542(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Acrolein inhalation prevents vascular_endothelial_growth_factor-induced mobilization of Flk-1 + / Sca-1 + cells in mice .
21156809	0	Sca-1	0,5	TGF-beta1	33,42	Sca-1	TGF-beta1	110454(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Sca-1 is negatively regulated by TGF-beta1 in myogenic cells .
10634171	0	Sca-1	98,103	Thy-1	106,111	Sca-1	Thy-1	110454(Tax:10090)	21838(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
18334674	0	Sca-1	62,67	c-Kit	69,74	Sca-1	c-Kit	20238(Tax:10090)	16590(Tax:10090)	Gene	Gene	Lin|amod|START_ENTITY Lin|dep|+ +|amod|END_ENTITY	Heparanase regulates retention and proliferation of primitive Sca-1 + / c-Kit + / Lin - cells via modulation of the bone marrow microenvironment .
20304046	0	Sca-1	39,44	c-Kit	32,37	Sca-1	c-Kit	20238(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|capability capability|dep|+ +|amod|END_ENTITY	Regeneration capability of Lin - / c-Kit + / Sca-1 + cells with or without radiation exposure for repopulation of peripheral blood in lethally irradiated mice monitored using Ly5 .1 isotype on days 35 , 90 , and 270 after transplantation .
20720596	0	Sca-1	0,5	c-Kit	8,13	Sca-1	c-Kit	20238(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|MDS MDS|nsubj|expression expression|amod|END_ENTITY	Sca-1 / c-Kit receptor expression and apoptosis pattern in ENU induced MDS mice .
9885214	0	Sca-1	71,76	c-Kit	64,69	Sca-1	c-Kit	836	3815	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	D3 : a gene induced during myeloid cell differentiation of Linlo c-Kit + Sca-1 -LRB- + -RRB- progenitor cells .
10634171	0	Sca-1	98,103	c-kit	118,123	Sca-1	c-kit	110454(Tax:10090)	16590(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|dep|+ +|amod|END_ENTITY	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
23273785	0	Sca-1	42,47	c-kit	35,40	Sca-1	c-kit	110454(Tax:10090)	16590(Tax:10090)	Gene	Gene	CXCR4|compound|START_ENTITY CXCR4|amod|END_ENTITY	Distribution and homing pattern of c-kit + Sca-1 + CXCR4 + resident cardiac stem cells in neonatal , postnatal , and adult mouse heart .
19254813	0	Sca1	33,37	CD31	39,43	Sca1	CD31	110454(Tax:10090)	18613(Tax:10090)	Gene	Gene	+|amod|START_ENTITY Differentiation|nmod|+ Differentiation|dep|END_ENTITY	Differentiation and migration of Sca1 + / CD31 - cardiac side population cells in a murine myocardial_ischemic model .
25048464	0	Sca1	19,23	CD44	31,35	Sca1	CD44	110454(Tax:10090)	12505(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|derived derived|nsubj|marrow marrow|compound|END_ENTITY	BMP-non-responsive Sca1 + CD73 + CD44 + mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation .
25268239	0	Sca1	31,35	CD44	41,45	Sca1	CD44	110454(Tax:10090)	12505(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Correction : BMP-Non-Responsive Sca1 + CD73 + CD44 + Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation .
25048464	0	Sca1	19,23	CD73	25,29	Sca1	CD73	110454(Tax:10090)	23959(Tax:10090)	Gene	Gene	+|nsubj|START_ENTITY +|ccomp|derived derived|nsubj|marrow marrow|compound|END_ENTITY	BMP-non-responsive Sca1 + CD73 + CD44 + mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation .
25268239	0	Sca1	31,35	CD73	36,40	Sca1	CD73	110454(Tax:10090)	23959(Tax:10090)	Gene	Gene	Cells|compound|START_ENTITY Cells|compound|END_ENTITY	Correction : BMP-Non-Responsive Sca1 + CD73 + CD44 + Mouse Bone Marrow Derived Osteoprogenitor Cells Respond to Combination of VEGF and BMP-6 to Display Enhanced Osteoblastic Differentiation and Ectopic Bone Formation .
11672547	0	Sca1	61,65	Flt3	16,20	Sca1	Flt3	12367(Tax:10090)	14255(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of Flt3 expression within the bone marrow Lin -LRB- - -RRB- Sca1 -LRB- + -RRB- c-kit -LRB- + -RRB- stem cell compartment is accompanied by loss of self-renewal capacity .
11672547	0	Sca1	61,65	c-kit	68,73	Sca1	c-kit	12367(Tax:10090)	16590(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of Flt3 expression within the bone marrow Lin -LRB- - -RRB- Sca1 -LRB- + -RRB- c-kit -LRB- + -RRB- stem cell compartment is accompanied by loss of self-renewal capacity .
17706246	0	Sca1	56,60	c-kit	62,67	Sca1	c-kit	20238(Tax:10090)	16590(Tax:10090)	Gene	Gene	+|amod|START_ENTITY differentiation|nmod|+ enhances|dobj|differentiation signaling|acl:relcl|enhances signaling|parataxis|adipose-derived adipose-derived|nsubj|+ +|amod|END_ENTITY	Non-canonical Wnt signaling enhances differentiation of Sca1 + / c-kit + adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes .
8789437	0	Sca1	111,115	spinocerebellar_ataxia_type_1	75,104	Sca1	spinocerebellar ataxia type 1	20238(Tax:10090)	20238(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and developmental expression analysis of the murine homolog of the spinocerebellar_ataxia_type_1 gene -LRB- Sca1 -RRB- .
23893242	0	Scaffold_attachment_factor_B1	0,29	MST1	107,111	Scaffold attachment factor B1	MST1	6294	4485	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Scaffold_attachment_factor_B1 regulates the androgen_receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2 .
23893242	0	Scaffold_attachment_factor_B1	0,29	androgen_receptor	44,61	Scaffold attachment factor B1	androgen receptor	6294	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Scaffold_attachment_factor_B1 regulates the androgen_receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2 .
22190905	0	Scavenger_Receptor_BI	16,37	Hepatic_Nuclear_Factor_4a	41,66	Scavenger Receptor BI	Hepatic Nuclear Factor 4a	25073(Tax:10116)	25735(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of Scavenger_Receptor_BI by Hepatic_Nuclear_Factor_4a through a Peroxisome Proliferator-Activated Receptor y-Dependent Mechanism in Liver .
26313465	0	Scavenger_Receptor_Class_B_Type_I	0,33	Apolipoprotein_E	51,67	Scavenger Receptor Class B Type I	Apolipoprotein E	20778(Tax:10090)	11816(Tax:10090)	Gene	Gene	Levels|compound|START_ENTITY Levels|compound|END_ENTITY	Scavenger_Receptor_Class_B_Type_I Regulates Plasma Apolipoprotein_E Levels and Dietary Lipid Deposition to the Liver .
24273937	0	Scc	51,54	SCC	81,84	Scc	SCC	6317	6317	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of Architect i2000 for determination of Scc with IMX determination of SCC with different methods .
15901674	0	Scc1	63,67	EGFR	77,81	Scc1	EGFR	5795	1956	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The C. _ elegans homolog of the mammalian tumor suppressor Dep-1 / Scc1 inhibits EGFR signaling to regulate binary cell fate decisions .
26923598	0	Scc1	77,81	Pds5	44,48	Scc1	Pds5	851561(Tax:4932)	855099(Tax:4932)	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Crystal Structure of the Cohesin Gatekeeper Pds5 and in Complex with Kleisin Scc1 .
12419843	0	Scd1	27,31	Stearoyl-CoA_desaturase_1	0,25	Scd1	Stearoyl-CoA desaturase 1	20249(Tax:10090)	20249(Tax:10090)	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Stearoyl-CoA_desaturase_1 -LRB- Scd1 -RRB- gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats .
22825870	0	Scd5	8,12	Sla1	81,85	Scd5	Sla1	854507(Tax:4932)	852276(Tax:4932)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Scd5 , a protein phosphatase-1 targeting protein , in phosphoregulation of Sla1 during endocytosis .
17898076	0	Scd5p	0,5	Glc7p	84,89	Scd5p	Glc7p	854507(Tax:4932)	856870(Tax:4932)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast .
12956961	0	Scd5p	55,60	Prk1p	28,33	Scd5p	Prk1p	854507(Tax:4932)	854713(Tax:4932)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The actin-regulating kinase Prk1p negatively regulates Scd5p , a suppressor of clathrin deficiency , in actin organization and endocytosis .
12586694	0	Sch9	29,33	SOD2	0,4	Sch9	SOD2	856612(Tax:4932)	856399(Tax:4932)	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	SOD2 functions downstream of Sch9 to extend longevity in yeast .
17560372	0	Sch9	0,4	TORC1	26,31	Sch9	TORC1	856612(Tax:4932)	23373	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Sch9 is a major target of TORC1 in Saccharomyces_cerevisiae .
19592487	0	Schlafen_2	8,18	SLFN2	20,25	Schlafen 2	SLFN2	20556(Tax:10090)	20556(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Schlafen_2 -LRB- SLFN2 -RRB- in the generation of interferon alpha-induced growth inhibitory responses .
26268420	0	Schlafen_3	0,10	Cdx2	51,55	Schlafen 3	Cdx2	501712(Tax:10116)	66019(Tax:10116)	Gene	Gene	Mediates|nsubj|START_ENTITY Mediates|dobj|Effects Effects|nmod|END_ENTITY	Schlafen_3 Mediates the Differentiating Effects of Cdx2 in Rat IEC-Cdx2L1 Enterocytes .
7774018	0	Schnurri	0,8	Dpp	36,39	Schnurri	Dpp	36171(Tax:7227)	33432(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1 .
17404274	0	Schnurri-2	0,10	Th1	27,30	Schnurri-2	Th1	15273(Tax:10090)	57314(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo .
14707112	0	Schnurri-3	0,10	c-Jun	32,37	Schnurri-3	c-Jun	16656(Tax:10090)	16476(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Schnurri-3 -LRB- KRC -RRB- interacts with c-Jun to regulate the IL-2 gene in T cells .
7561890	0	Schwannoma-derived_growth_factor	0,32	epidermal_growth_factor_receptor	52,84	Schwannoma-derived growth factor	epidermal growth factor receptor	374	1956	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Schwannoma-derived_growth_factor interacts with the epidermal_growth_factor_receptor .
15274303	0	Sciellin	12,20	SCEL	22,26	Sciellin	SCEL	8796	8796	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of Sciellin -LRB- SCEL -RRB- as a candidate gene in esophageal_squamous_cell_carcinoma .
10749680	0	Sck	33,36	KDR	107,110	Sck	KDR	25759	3791	Gene	Gene	protein|appos|START_ENTITY forms|nsubj|protein forms|dobj|END_ENTITY	The Shc-related adaptor protein , Sck , forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells .
9790910	0	Sck	0,3	KDR	19,22	Sck	KDR	25759	3791	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sck interacts with KDR and Flt-1 via its SH2 domain .
23653374	0	Scleraxis	12,21	Smad3	0,5	Scleraxis	Smad3	20289(Tax:10090)	17127(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization .
16876153	0	Scleraxis	0,9	tenomodulin	49,60	Scleraxis	tenomodulin	374101(Tax:9031)	404530(Tax:9031)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Scleraxis positively regulates the expression of tenomodulin , a differentiation marker of tenocytes .
15778503	0	Sclerostin	0,10	LRP5/6	20,26	Sclerostin	LRP5/6	50964	4041;4040	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling .
20816666	0	Sclerostin	0,10	osterix	74,81	Sclerostin	osterix	74499(Tax:10090)	170574(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Sclerostin is a direct target of osteoblast-specific transcription factor osterix .
9143495	0	Scn10a	113,119	voltage-gated_sodium_channel	78,106	Scn10a	voltage-gated sodium channel	20264(Tax:10090)	20264(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a mouse sensory neuron tetrodotoxin-resistant voltage-gated_sodium_channel gene , Scn10a .
8812438	0	Scn1a	79,84	Scn2a	86,91	Scn1a	Scn2a	20265(Tax:10090)	110876(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
8812438	0	Scn1a	79,84	Scn3a	93,98	Scn1a	Scn3a	20265(Tax:10090)	20269(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
26410685	0	Scn1a	3,8	Scn8a	30,35	Scn1a	Scn8a	20265(Tax:10090)	20273(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior .
8812438	0	Scn2a	86,91	Scn1a	79,84	Scn2a	Scn1a	110876(Tax:10090)	20265(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
8812438	0	Scn2a	86,91	Scn3a	93,98	Scn2a	Scn3a	110876(Tax:10090)	20269(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
8812438	0	Scn3a	93,98	Scn1a	79,84	Scn3a	Scn1a	20269(Tax:10090)	20265(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
8812438	0	Scn3a	93,98	Scn2a	86,91	Scn3a	Scn2a	20269(Tax:10090)	110876(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
22728936	0	Scn5a	12,17	TBX5	0,4	Scn5a	TBX5	6331	6910	Gene	Gene	expression|amod|START_ENTITY drives|dobj|expression drives|nsubj|END_ENTITY	TBX5 drives Scn5a expression to regulate cardiac conduction system function .
26410685	0	Scn8a	30,35	Scn1a	3,8	Scn8a	Scn1a	20273(Tax:10090)	20265(Tax:10090)	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior .
8812438	0	Scn9a	41,46	sodium_channel_alpha-subunit	6,34	Scn9a	sodium channel alpha-subunit	20274(Tax:10090)	110880(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
18164684	0	Scotin	0,6	p63	14,17	Scotin	p63	51246	8626	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	Scotin : A new p63 target gene expressed during epidermal differentiation .
16613610	0	Scr	65,68	Hox	69,72	Scr	Hox	252583	42536(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene : understanding the role of Enhancers of trithorax and Polycomb .
2900718	0	Scrapie-associated_fibrils	0,26	PrP	28,31	Scrapie-associated fibrils	PrP	74451(Tax:10090)	19122(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Scrapie-associated_fibrils , PrP protein and the Sinc gene .
15649318	0	Scrib	21,26	LPP	68,71	Scrib	LPP	23513	4026	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The tumor suppressor Scrib interacts with the zyxin-related protein LPP , which shuttles between cell adhesion sites and the nucleus .
19555689	0	Scrib	35,40	MCC	0,3	Scrib	MCC	23513	4163	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	MCC , a new interacting protein for Scrib , is required for cell migration in epithelial cells .
19563796	0	Scribble	38,46	Stbm/Vang	83,92	Scribble	Stbm/Vang	44448(Tax:7227)	35922(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors .
24527800	0	Scribble	8,16	miR-296	0,7	Scribble	miR-296	23513	407022	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	miR-296 / Scribble axis is deregulated in human breast_cancer and miR-296 restoration reduces tumour growth in vivo .
24131633	0	Scube2	70,76	Emilin3	0,7	Scube2	Emilin3	503728(Tax:7955)	101882042	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Emilin3 is required for notochord_sheath integrity and interacts with Scube2 to regulate notochord-derived Hedgehog signals .
24522195	0	Scube2	0,6	Shh	28,31	Scube2	Shh	57758	6469	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|processing processing|compound|END_ENTITY	Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells .
12612581	0	Scurfin	22,29	CD25	37,41	Scurfin	CD25	20371(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	An essential role for Scurfin in CD4 + CD25 + T regulatory cells .
12612581	0	Scurfin	22,29	CD4	33,36	Scurfin	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	An essential role for Scurfin in CD4 + CD25 + T regulatory cells .
12874208	0	Scurfin	0,7	CD4	84,87	Scurfin	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|regulation regulation|nmod|function function|compound|END_ENTITY	Scurfin -LRB- FoxP3 -RRB- controls T-dependent immune responses in vivo through regulation of CD4 + T cell effector function .
16777091	0	Scythe	37,43	SGT	6,9	Scythe	SGT	7917	6449	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human SGT interacts with Bag-6 / Bat-3 / Scythe and cells with reduced levels of either protein display persistence of few misaligned chromosomes and mitotic_arrest .
16336274	0	Scythe	102,108	Xrpn10c	26,33	Scythe	Xrpn10c	379698(Tax:8355)	399421(Tax:8355)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein Scythe .
19897479	0	Sdc1	80,84	Dpy-30	63,69	Sdc1	Dpy-30	6382	84661	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression .
25890097	0	Sdf-1	0,5	CD9	23,26	Sdf-1	CD9	20315(Tax:10090)	12527(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- induces CD9 expression in stem cells engaged in muscle regeneration .
25890097	0	Sdf-1	0,5	CD9	23,26	Sdf-1	CD9	20315(Tax:10090)	12527(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- induces CD9 expression in stem cells engaged in muscle regeneration .
22978573	0	Sdf-1	0,5	Cxcr4	77,82	Sdf-1	Cxcr4	6387	7852	Gene	Gene	improves|nsubj|START_ENTITY improves|dep|expressing expressing|nsubj|regeneration regeneration|nmod|mobilisation mobilisation|nmod|END_ENTITY	Sdf-1 -LRB- CXCL12 -RRB- improves skeletal muscle regeneration via the mobilisation of Cxcr4 and CD34 expressing cells .
21402054	0	Sdi1	12,16	p21	8,11	Sdi1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Loss of p21 -LRB- Sdi1 -RRB- expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21 -LRB- Sdi1 -RRB- gene promoter .
20921135	0	Sds22	0,5	aurora_B	16,24	Sds22	aurora B	5510	9212	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Sds22 regulates aurora_B activity and microtubule-kinetochore interactions at mitosis .
15531216	0	Seb1	40,44	glycerol_dehydrogenase	79,101	Seb1	glycerol dehydrogenase	856821(Tax:4932)	853106(Tax:4932)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	The fungal STRE-element-binding protein Seb1 is involved but not essential for glycerol_dehydrogenase -LRB- gld1 -RRB- gene expression and glycerol accumulation in Trichoderma atroviride during osmotic stress .
14660662	0	Sec	49,52	Trsp	54,58	Sec	Trsp	65967(Tax:10090)	22069(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Specific excision of the selenocysteine tRNA -LSB- Ser -RSB- Sec -LRB- Trsp -RRB- gene in mouse liver demonstrates an essential role of selenoproteins in liver function .
7946348	0	Sec1	35,39	rop	0,3	Sec1	rop	851742(Tax:4932)	111335(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	rop , a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1 / Munc-18 proteins , is a negative regulator of neurotransmitter release in vivo .
9152025	0	Sec12p	0,6	Rer1p	16,21	Sec12p	Rer1p	855760(Tax:4932)	850354(Tax:4932)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Sec12p requires Rer1p for sorting to coatomer -LRB- COPI -RRB- - coated vesicles and retrieval to the ER .
15292201	0	Sec15	0,5	Rab11	29,34	Sec15	Rab11	54536	8766	Gene	Gene	effector|nsubj|START_ENTITY effector|nmod|GTPase GTPase|amod|END_ENTITY	Sec15 is an effector for the Rab11 GTPase in mammalian cells .
16155582	0	Sec15	0,5	Rab11	21,26	Sec15	Rab11	42499(Tax:7227)	42501(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo .
25201882	0	Sec16A	39,45	Leucine-rich_repeat_kinase_2	0,28	Sec16A	Leucine-rich repeat kinase 2	9919	120892	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Leucine-rich_repeat_kinase_2 regulates Sec16A at ER exit sites to allow ER-Golgi export .
8109176	0	Sec18p	62,68	Cdc48p	77,83	Sec18p	Cdc48p	852372(Tax:4932)	851431(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	Sec18p	62,68	Pas1p	70,75	Sec18p	Pas1p	852372(Tax:4932)	853636(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	Sec18p	62,68	TBP-1	85,90	Sec18p	TBP-1	852372(Tax:4932)	856891(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
16006618	0	Sec1p	125,130	Mso1p	155,160	Sec1p	Mso1p	851742(Tax:4932)	855785(Tax:4932)	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	A gene truncation strategy generating N - and C-terminal deletion variants of proteins for functional studies : mapping of the Sec1p binding domain in yeast Mso1p by a Mu in vitro transposition-based approach .
12045183	0	Sec2p	61,66	Sec4p	19,24	Sec2p	Sec4p	855449(Tax:4932)	850543(Tax:4932)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Ypt32 recruits the Sec4p guanine_nucleotide exchange factor , Sec2p , to secretory vesicles ; evidence for a Rab cascade in yeast .
17620726	0	Sec2p	55,60	Sec4p	124,129	Sec2p	Sec4p	855449(Tax:4932)	850543(Tax:4932)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|factor factor|nmod|END_ENTITY	Crystallization and crystallographic analysis of yeast Sec2p , a guanine_nucleotide-exchange factor for the yeast Rab GTPase Sec4p .
9199166	0	Sec2p	0,5	Sec4p	38,43	Sec2p	Sec4p	855449(Tax:4932)	850543(Tax:4932)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles .
16181645	0	Sec3	45,49	GLYT1	24,29	Sec3	GLYT1	55763	6536	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The glycine transporter GLYT1 interacts with Sec3 , a component of the exocyst complex .
16957052	0	Sec31A	83,89	ALG-2	25,30	Sec31A	ALG-2	22872	85365	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	The Ca2 + - binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A .
17196169	0	Sec31A	21,27	ALG-2	0,5	Sec31A	ALG-2	22872	85365	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2 + - dependent manner .
8375508	0	Sec4	15,19	GDI	25,28	Sec4	GDI	850543(Tax:4932)	34264(Tax:7227)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Interaction of Sec4 with GDI proteins from bovine brain , Drosophila_melanogaster and Saccharomyces_cerevisiae .
9218467	0	Sec4p	53,58	Dss4p	42,47	Sec4p	Dss4p	850543(Tax:4932)	856128(Tax:4932)	Gene	Gene	release|nmod|START_ENTITY release|dobj|END_ENTITY	Interactions of nucleotide release factor Dss4p with Sec4p in the post-Golgi secretory pathway of yeast .
12045183	0	Sec4p	19,24	Sec2p	61,66	Sec4p	Sec2p	850543(Tax:4932)	855449(Tax:4932)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Ypt32 recruits the Sec4p guanine_nucleotide exchange factor , Sec2p , to secretory vesicles ; evidence for a Rab cascade in yeast .
17620726	0	Sec4p	124,129	Sec2p	55,60	Sec4p	Sec2p	850543(Tax:4932)	855449(Tax:4932)	Gene	Gene	factor|nmod|START_ENTITY analysis|appos|factor analysis|nmod|END_ENTITY	Crystallization and crystallographic analysis of yeast Sec2p , a guanine_nucleotide-exchange factor for the yeast Rab GTPase Sec4p .
9199166	0	Sec4p	38,43	Sec2p	0,5	Sec4p	Sec2p	850543(Tax:4932)	855449(Tax:4932)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles .
12459492	0	Sec5	105,109	DelGEF	0,6	Sec5	DelGEF	55770	26297	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	DelGEF , a homologue of the Ran guanine_nucleotide exchange factor RanGEF , binds to the exocyst component Sec5 and modulates secretion .
18555783	0	Sec61	21,26	BAP31	0,5	Sec61	BAP31	29927	10134	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex .
21558796	0	Sec61	50,55	Calmodulin	0,10	Sec61	Calmodulin	851095(Tax:4932)	852406(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates .
10799540	0	Sec61	10,15	Sec62	35,40	Sec61	Sec62	29927	7095	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Mammalian Sec61 is associated with Sec62 and Sec63 .
9565615	0	Sec61	105,110	apoB	93,97	Sec61	apoB	29927	338	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex .
8707849	0	Sec61p	32,38	emo-1	0,5	Sec61p	emo-1	178407(Tax:6239)	179510(Tax:6239)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	emo-1 , a Caenorhabditis_elegans Sec61p gamma homologue , is required for oocyte development and ovulation .
10799540	0	Sec62	35,40	Sec61	10,15	Sec62	Sec61	7095	29927	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Mammalian Sec61 is associated with Sec62 and Sec63 .
23287549	0	Sec62	66,71	Sec63	29,34	Sec62	Sec63	7095	11231	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	CK2 phosphorylation of human Sec63 regulates its interaction with Sec62 .
23287549	0	Sec63	29,34	Sec62	66,71	Sec63	Sec62	11231	7095	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	CK2 phosphorylation of human Sec63 regulates its interaction with Sec62 .
10608818	0	Sec7	51,55	ADP_ribosylation_factor_1	20,45	Sec7	ADP ribosylation factor 1	9267	375	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Dual interaction of ADP_ribosylation_factor_1 with Sec7 domain and with lipid membranes during catalysis of guanine_nucleotide exchange .
23255605	0	Sec7	73,77	Arno	88,92	Sec7	Arno	9267	9266	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Kinetics of interaction between ADP-ribosylation_factor-1 -LRB- Arf1 -RRB- and the Sec7 domain of Arno guanine_nucleotide exchange factor , modulation by allosteric factors , and the uncompetitive inhibitor brefeldin_A .
24112024	0	Sec7	48,52	Arno	63,67	Sec7	Arno	9267	9266	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Fragment-based identification of a locus in the Sec7 domain of Arno for the design of protein-protein interaction inhibitors .
9476900	0	Sec7	52,56	arno	73,77	Sec7	arno	9267	9266	Gene	Gene	domain|compound|START_ENTITY Structure|nmod|domain Structure|nmod|END_ENTITY	Structure of the guanine_nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase .
19006485	0	Sec8	62,66	Insulin	0,7	Sec8	Insulin	60412	3630	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes .
25725287	0	Sec8	0,4	cytokeratin8	15,27	Sec8	cytokeratin8	60412	3856	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways .
9507024	0	Secondary_lymphoid-tissue_chemokine	0,35	CCR7	89,93	Secondary lymphoid-tissue chemokine	CCR7	6366	1236	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Secondary_lymphoid-tissue_chemokine is a functional ligand for the CC chemokine receptor CCR7 .
19277043	0	Secreted_Frizzled-related_protein-1	0,35	androgen_receptor	63,80	Secreted Frizzled-related protein-1	androgen receptor	6422	367	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	Secreted_Frizzled-related_protein-1 is a negative regulator of androgen_receptor activity in prostate_cancer .
25418420	0	Secreted_Phosphoprotein_24_kD	45,74	BMP-2	97,102	Secreted Phosphoprotein 24 kD	BMP-2	6694	650	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	A Carboxy Terminal BMP/TGF-b Binding Site in Secreted_Phosphoprotein_24_kD Independently Affects BMP-2 Activity .
25355716	0	Secreted_Protein_Acidic_and_Rich_in_Cysteine	14,58	SPARC	60,65	Secreted Protein Acidic and Rich in Cysteine	SPARC	6678	6678	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Secreted_Protein_Acidic_and_Rich_in_Cysteine -LRB- SPARC -RRB- in Breast_Cancer and Response to Neoadjuvant Chemotherapy .
18567805	0	Secreted_frizzled-related_protein_4	0,35	Wnt7a	50,55	Secreted frizzled-related protein 4	Wnt7a	6424	7476	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Secreted_frizzled-related_protein_4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial_cancer cells .
19571258	0	Secreted_phosphoprotein_1	0,25	integrin_alpha_v_beta_6	55,78	Secreted phosphoprotein 1	integrin alpha v beta 6	25353(Tax:10116)	311061(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Secreted_phosphoprotein_1 -LRB- SPP1 , osteopontin -RRB- binds to integrin_alpha_v_beta_6 on porcine trophectoderm cells and integrin_alpha_v_beta_3 on uterine luminal epithelial cells , and promotes trophectoderm cell adhesion and migration .
1098482	0	Secretin	0,8	gastrin	19,26	Secretin	gastrin	483407(Tax:9615)	100685087	Gene	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Secretin effect on gastrin , gastric secretion in dogs with chronic antral stimulation .
6946754	0	Secretin	0,8	pancreatic_polypeptide	20,42	Secretin	pancreatic polypeptide	6343	5539	Gene	Gene	START_ENTITY|acl|stimulated stimulated|xcomp|END_ENTITY	Secretin stimulated pancreatic_polypeptide : a test for chronic_pancreatitis .
23820082	0	Secretoglobin_1A_member_1	0,25	SCGB1A1	27,34	Secretoglobin 1A member 1	SCGB1A1	7356	7356	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Secretoglobin_1A_member_1 -LRB- SCGB1A1 -RRB- +38 A/G polymorphism is associated with asthma risk : a meta-analysis .
19357184	0	Secretogranin_II	0,16	secretogranin_III	26,43	Secretogranin II	secretogranin III	20254(Tax:10090)	20255(Tax:10090)	Gene	Gene	binds|compound|START_ENTITY binds|nmod|END_ENTITY	Secretogranin_II binds to secretogranin_III and forms secretory granules with orexin , neuropeptide_Y , and POMC .
21295544	0	Secretory_Carrier_Membrane_Protein_2	59,95	dopamine_transporter	18,38	Secretory Carrier Membrane Protein 2	dopamine transporter	10066	6531	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of the dopamine_transporter by interaction with Secretory_Carrier_Membrane_Protein_2 .
26328314	0	Secretory_Leukocyte_Protease_Inhibitor	12,50	SLPI	52,56	Secretory Leukocyte Protease Inhibitor	SLPI	20568(Tax:10090)	20568(Tax:10090)	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Function of Secretory_Leukocyte_Protease_Inhibitor -LRB- SLPI -RRB- in Odontoblast During Mouse Tooth Development .
25035816	0	Secretory_Phospholipase_A2	44,70	C/EBP	79,84	Secretory Phospholipase A2	C/EBP	29692(Tax:10116)	25301(Tax:10116)	Gene	Gene	Gene|compound|START_ENTITY Regulation|nmod|Gene Regulation|nmod|END_ENTITY	Transcriptional Regulation of the Group IIA Secretory_Phospholipase_A2 Gene by C/EBP in Rat liver and its Relationship to Hepatic Gluconeogenesis during Sepsis .
26239418	0	Secretory_leukocyte_protease_inhibitor	0,38	polymeric_immunoglobulin_receptor	62,95	Secretory leukocyte protease inhibitor	polymeric immunoglobulin receptor	6590	5284	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Secretory_leukocyte_protease_inhibitor inhibits expression of polymeric_immunoglobulin_receptor via the NF-kB signaling pathway .
20108251	0	Sedlin	15,21	PAM14	27,32	Sedlin	PAM14	6399	93621	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Sedlin with PAM14 .
24190321	0	Segregation_Distorter	4,25	SD	27,29	Segregation Distorter	SD	35223(Tax:7227)	35223(Tax:7227)	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	The Segregation_Distorter -LRB- SD -RRB- complex and the accumulation of deleterious genes in laboratory strains of Drosophila_melanogaster .
24807223	0	Seipin	0,6	SERCA	73,78	Seipin	SERCA	31245(Tax:7227)	49297(Tax:7227)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Seipin promotes adipose tissue fat storage through the ER Ca - ATPase SERCA .
9789074	0	Sek1	7,11	EphA4	0,5	Sek1	EphA4	13838(Tax:10090)	13838(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	EphA4 -LRB- Sek1 -RRB- receptor tyrosine kinase is required for the development of the corticospinal tract .
25066055	0	Sel1L	46,51	LPL	62,65	Sel1L	LPL	20338(Tax:10090)	16956(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism .
24342607	0	SelR	45,49	methionine_sulfoxide_reductase	10,40	SelR	methionine sulfoxide reductase	51734	4552	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effect of methionine_sulfoxide_reductase B1 -LRB- SelR -RRB- gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells .
18194465	0	Seladin-1	0,9	DHCR24	10,16	Seladin-1	DHCR24	1718	1718	Gene	Gene	START_ENTITY|parataxis|protects protects|nsubj|END_ENTITY	Seladin-1 / DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content .
26628388	0	Seladin-1	0,9	DHCR24	10,16	Seladin-1	DHCR24	74754(Tax:10090)	74754(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|Neuroprotective Neuroprotective|nsubj|END_ENTITY	Seladin-1 / DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke .
21849499	0	Selenoprotein_K	0,15	m-calpain	37,46	Selenoprotein K	m-calpain	80795(Tax:10090)	12334(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Selenoprotein_K is a novel target of m-calpain , and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages .
23805218	0	Selenoprotein_R	22,37	Clusterin	43,52	Selenoprotein R	Clusterin	51734	1191	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Direct Interaction of Selenoprotein_R with Clusterin and Its Possible Role in Alzheimer 's _ Disease .
22982242	0	Selenoprotein_W	0,15	CDC25B	86,92	Selenoprotein W	CDC25B	6415	994	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Selenoprotein_W promotes cell cycle recovery from G2 arrest through the activation of CDC25B .
25721765	0	Selenoprotein_W	0,15	epidermal_growth_factor_receptor	25,57	Selenoprotein W	epidermal growth factor receptor	6415	1956	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	Selenoprotein_W controls epidermal_growth_factor_receptor surface expression , activation and degradation via receptor ubiquitination .
19515904	0	Sema3A	114,120	HGF	76,79	Sema3A	HGF	10371	3082	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Possible implication of satellite cells in regenerative motoneuritogenesis : HGF upregulates neural chemorepellent Sema3A during myogenic differentiation .
24439904	0	Sema4A	0,6	IFN-b	42,47	Sema4A	IFN-b	64218	3456	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Sema4A inhibits the therapeutic effect of IFN-b in EAE .
24142719	0	Sema4C	21,27	Erbin	0,5	Sema4C	Erbin	54910	55914	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells .
22189792	0	Sema4D	0,6	Plexin_B1	23,32	Sema4D	Plexin B1	10507	5364	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Sema4D , the ligand for Plexin_B1 , suppresses c-Met activation and migration and promotes melanocyte survival and growth .
22189792	0	Sema4D	0,6	c-Met	45,50	Sema4D	c-Met	10507	4233	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Sema4D , the ligand for Plexin_B1 , suppresses c-Met activation and migration and promotes melanocyte survival and growth .
16481103	0	Sema5A	31,37	semaphorin_5A	16,29	Sema5A	semaphorin 5A	9037	9037	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism in semaphorin_5A -LRB- Sema5A -RRB- gene is not a marker of Parkinson 's _ disease risk .
20727575	0	Sema7A	73,79	PlexinC1	104,112	Sema7A	PlexinC1	8482	10154	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1 .
9331348	0	Sema_E	103,109	Neuropilin-2	0,12	Sema E	Neuropilin-2	10512	8828	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Neuropilin-2 , a novel member of the neuropilin family , is a high affinity receptor for the semaphorins Sema_E and Sema_IV but not Sema_III .
11014819	0	Semaphorin-1a	0,13	fasciclin_II	63,75	Semaphorin-1a	fasciclin II	34192(Tax:7227)	31364(Tax:7227)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin_II and connectin to regulate axon fasciculation in Drosophila .
25529012	0	Semaphorin-3F	0,13	Rac1	81,85	Semaphorin-3F	Rac1	6405	5879	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Semaphorin-3F suppresses the stemness of colorectal_cancer cells by inactivating Rac1 .
19217374	0	Semaphorin6A	90,102	FARP1	0,5	Semaphorin6A	FARP1	57556	10160	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling .
25843720	0	Semaphorin_3A	32,45	Synapsin_III	0,12	Semaphorin 3A	Synapsin III	10371	8224	Gene	Gene	Downstream|nmod|START_ENTITY Downstream|compound|END_ENTITY	Synapsin_III Acts Downstream of Semaphorin_3A / CDK5 Signaling to Regulate Radial Migration and Orientation of Pyramidal Neurons In Vivo .
21945444	0	Semaphorin_3A	0,13	neuropilin-1	46,58	Semaphorin 3A	neuropilin-1	10371	8829	Gene	Gene	hybrid|amod|START_ENTITY peptide|nsubj|hybrid peptide|xcomp|binding binding|advcl|END_ENTITY	Semaphorin_3A lytic hybrid peptide binding to neuropilin-1 as a novel anti-cancer agent in pancreatic_cancer .
24918638	0	Semaphorin_3A	0,13	neuropilin-1	32,44	Semaphorin 3A	neuropilin-1	20346(Tax:10090)	18186(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|END_ENTITY	Semaphorin_3A signaling through neuropilin-1 is an early trigger for distal axonopathy in the SOD1G93A mouse model of amyotrophic_lateral_sclerosis .
18922901	0	Semaphorin_3B	0,13	neuropilin-1	77,89	Semaphorin 3B	neuropilin-1	7869	8829	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Semaphorin_3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast_cancer cells .
26648031	0	Semaphorin_4A	0,13	Akt	59,62	Semaphorin 4A	Akt	64218	207	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Semaphorin_4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor .
15978582	0	Semaphorin_4B	0,13	SAP90	70,75	Semaphorin 4B	SAP90	10509	1742	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Semaphorin_4B interacts with the post-synaptic density protein PSD-95 / SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif .
20610402	0	Semaphorin_4D	0,13	Plexin-B1	14,23	Semaphorin 4D	Plexin-B1	10507	5364	Gene	Gene	START_ENTITY|parataxis|stimulates stimulates|nsubj|END_ENTITY	Semaphorin_4D / Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity , inducing growth cone collapse in hippocampal neurons .
22476930	0	Semaphorin_4D	0,13	VEGF	30,34	Semaphorin 4D	VEGF	10507	7422	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Semaphorin_4D cooperates with VEGF to promote angiogenesis and tumor progression .
16055703	0	Semaphorin_4D	0,13	plexin-B1	14,23	Semaphorin 4D	plexin-B1	10507	5364	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Semaphorin_4D / plexin-B1 induces endothelial cell migration through the activation of PYK2 , Src , and the phosphatidylinositol_3-kinase-Akt pathway .
22821546	0	Semaphorin_5A	0,13	MMP9	125,129	Semaphorin 5A	MMP9	9037	4318	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Semaphorin_5A , an axon guidance molecule , enhances the invasion and metastasis of human gastric_cancer through activation of MMP9 .
22448926	0	Semaphorin_7A	0,13	CD34	48,52	Semaphorin 7A	CD34	8482	947	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|compound|END_ENTITY	Semaphorin_7A inhibits platelet production from CD34 + progenitor cells .
21524887	0	Semaphorin_7A	0,13	interleukin-8	39,52	Semaphorin 7A	interleukin-8	8482	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Semaphorin_7A on keratinocytes induces interleukin-8 production by monocytes .
12606817	0	Semicarbazide-sensitive_amine_oxidase	0,37	SSAO	39,43	Semicarbazide-sensitive amine oxidase	SSAO	11754(Tax:10090)	11754(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- gene expression in alloxan-induced diabetes in mice .
1899791	0	Semicarbazide-sensitive_amine_oxidase	0,37	SSAO	48,52	Semicarbazide-sensitive amine oxidase	SSAO	29473(Tax:10116)	29473(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Semicarbazide-sensitive_amine_oxidase activity -LRB- SSAO -RRB- of rat epididymal white adipose tissue .
15358188	0	Senescence_marker_protein-30	0,28	Akt	39,42	Senescence marker protein-30	Akt	9104	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Senescence_marker_protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells .
21347421	0	Senescence_marker_protein_30	0,28	SMP30	30,35	Senescence marker protein 30	SMP30	9104	9104	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Senescence_marker_protein_30 -LRB- SMP30 -RRB- expression in eukaryotic cells : existence of multiple species and membrane localization .
16585534	0	Senescence_marker_protein_30	0,28	gluconolactonase	42,58	Senescence marker protein 30	gluconolactonase	19733(Tax:10090)	19733(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Senescence_marker_protein_30 functions as gluconolactonase in L-ascorbic_acid biosynthesis , and its knockout mice are prone to scurvy .
7720696	0	Sep1	10,14	Kem1	18,22	Sep1	Kem1	852702(Tax:4932)	852702(Tax:4932)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role of Sep1 -LRB- = Kem1 , Xrn1 -RRB- as a microtubule-associated protein in Saccharomyces_cerevisiae .
8529461	0	Sep1	44,48	Kem1	60,64	Sep1	Kem1	852702(Tax:4932)	852702(Tax:4932)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification of functional domains in the Sep1 protein -LRB- = Kem1 , Xrn1 -RRB- , which is required for transition through meiotic prophase in Saccharomyces_cerevisiae .
9802570	0	Sep1	38,42	hSEP1	44,49	Sep1	hSEP1	54464	54464	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of human Sep1 -LRB- hSEP1 -RRB- gene and cytoplasmic localization of its product .
26531105	0	Sep15	35,40	15-kDa_selenoprotein	13,33	Sep15	15-kDa selenoprotein	9403	9403	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Knockdown of 15-kDa_selenoprotein -LRB- Sep15 -RRB- increases hLE cells ' susceptibility to tunicamycin-induced apoptosis .
26264612	0	Sep15	84,89	selenoprotein_15-kDa	62,82	Sep15	selenoprotein 15-kDa	9403	9403	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The 811_C / T polymorphism in the 3 ' untranslated region of the selenoprotein_15-kDa -LRB- Sep15 -RRB- gene and breast_cancer in Caucasian women .
18762578	0	Separase	0,8	Zds1	25,29	Separase	Zds1	852990(Tax:4932)	855316(Tax:4932)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase .
14723703	0	Sept2	17,22	GLAST	49,54	Sept2	GLAST	4735	6507	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	Mammalian septin Sept2 modulates the activity of GLAST , a glutamate transporter in astrocytes .
17224448	0	Sept5	30,35	CDCrel-1	37,45	Sept5	CDCrel-1	18951(Tax:10090)	18951(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of adult type Sept5 -LRB- CDCrel-1 -RRB- by cyclin-dependent_kinase_5 inhibits interaction with syntaxin-1 .
17224448	0	Sept5	30,35	cyclin-dependent_kinase_5	50,75	Sept5	cyclin-dependent kinase 5	18951(Tax:10090)	12568(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|interaction interaction|amod|END_ENTITY	Phosphorylation of adult type Sept5 -LRB- CDCrel-1 -RRB- by cyclin-dependent_kinase_5 inhibits interaction with syntaxin-1 .
11809673	0	Septin6	36,43	SEPTIN6	0,7	Septin6	SEPTIN6	56526(Tax:10090)	23157	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	SEPTIN6 , a human homologue to mouse Septin6 , is fused to MLL in infant acute_myeloid_leukemia with complex_chromosomal_abnormalities involving 11q23 and Xq24 .
20181826	0	Septin_14	0,9	Septin_4	74,82	Septin 14	Septin 4	346288	5414	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Septin_14 is involved in cortical neuronal migration via interaction with Septin_4 .
20181826	0	Septin_4	74,82	Septin_14	0,9	Septin 4	Septin 14	5414	346288	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Septin_14 is involved in cortical neuronal migration via interaction with Septin_4 .
18460473	0	Septin_7	0,8	centromere-associated_protein_E	24,55	Septin 7	centromere-associated protein E	989	1062	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Septin_7 interacts with centromere-associated_protein_E and is required for its kinetochore localization .
26823018	0	Septin_9	0,8	KIF17	32,37	Septin 9	KIF17	83788(Tax:10116)	500571(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Septin_9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport .
12492400	0	Ser-15	151,157	c-Jun_N-terminal_kinase	89,112	Ser-15	c-Jun N-terminal kinase	3190208(Tax:176280)	26419(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Low levels of glutathione_peroxidase_1 activity in selenium-deficient mouse liver affect c-Jun_N-terminal_kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis .
10637289	0	Ser-16	44,50	alpha1	26,32	Ser-16	alpha1	3190209(Tax:176280)	146	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Is phosphorylation of the alpha1 subunit at Ser-16 involved in the control of Na,K-ATPase activity by phorbol_ester-activated protein kinase C ?
11726503	0	Ser10	64,69	p27	0,3	Ser10	p27	3190220(Tax:176280)	10671	Gene	Gene	phosphorylation|nmod|START_ENTITY regulated|nmod|phosphorylation regulated|nsubjpass|localization localization|amod|END_ENTITY	p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis .
20811053	0	Ser10	105,110	p27	98,101	Ser10	p27	3190220(Tax:176280)	10671	Gene	Gene	FGF-2-mediated|nmod|START_ENTITY FGF-2-mediated|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	PI_3-kinase / Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2 .
21948550	0	Ser10	76,81	p27	58,61	Ser10	p27	3190220(Tax:176280)	10671	Gene	Gene	Kip1|nmod|START_ENTITY Kip1|amod|END_ENTITY	Human corneal endothelial cells employ phosphorylation of p27 -LRB- Kip1 -RRB- at both Ser10 and Thr187 sites for FGF-2-mediated cell proliferation via PI 3-kinase .
25908026	0	Ser10	31,36	p27	8,11	Ser10	p27	3190220(Tax:176280)	12576(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK .
25908026	0	Ser10	31,36	p27	8,11	Ser10	p27	3190220(Tax:176280)	12576(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK .
17932951	0	Ser15	163,168	Mdm2	54,58	Ser15	Mdm2	3190208(Tax:176280)	4193	Gene	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|advcl|induces induces|xcomp|phosphorylation phosphorylation|nsubj|END_ENTITY	Anti-diol_epoxide of benzo -LSB- a -RSB- pyrene induces transient Mdm2 and p53 Ser15 phosphorylation , while anti-diol_epoxide of dibenzo -LSB- a , l -RSB- pyrene induces a nontransient p53 Ser15 phosphorylation .
11495913	0	Ser15	117,122	p53	40,43	Ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY p38MAPK|nmod|phosphorylation induces|nmod|p38MAPK induces|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Osmotic_shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20 .
11562441	0	Ser15	136,141	p53	110,113	Ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	unmodified|nmod|START_ENTITY accumulation|acl:relcl|unmodified accumulation|nmod|END_ENTITY	The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382 .
12853888	0	Ser15	15,20	p53	40,43	Ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint .
15381086	0	Ser15	52,57	p53	37,40	Ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	substituted|nmod|START_ENTITY substituted|dobj|protein protein|compound|END_ENTITY	Stabilization of alanine substituted p53 protein at Ser15 , Thr18 , and Ser20 in response to ionizing radiation .
17932951	0	Ser15	163,168	p53	159,162	Ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Anti-diol_epoxide of benzo -LSB- a -RSB- pyrene induces transient Mdm2 and p53 Ser15 phosphorylation , while anti-diol_epoxide of dibenzo -LSB- a , l -RSB- pyrene induces a nontransient p53 Ser15 phosphorylation .
22288499	0	Ser15	4,9	p53	0,3	Ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nummod|END_ENTITY	p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia .
22532570	0	Ser15	73,78	p53	52,55	Ser15	p53	3190208(Tax:176280)	22060(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY activates|nmod|phosphorylation activates|dobj|function function|compound|END_ENTITY	Murine_protein_serine-threonine_kinase_38 activates p53 function through Ser15 phosphorylation .
23759592	0	Ser15	4,9	p53	0,3	Ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nummod|END_ENTITY	p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells .
8125092	0	Ser16	58,63	oncoprotein_18	40,54	Ser16	oncoprotein 18	3190209(Tax:176280)	3925	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell-cycle-regulated phosphorylation of oncoprotein_18 on Ser16 , Ser25 and Ser38 .
17384224	0	Ser2	32,36	CB1	53,56	Ser2	CB1	3714	1268	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Mutation studies of Ser7 .39 and Ser2 .60 in the human CB1 cannabinoid receptor : evidence for a serine-induced bend in CB1 transmembrane helix 7 .
21113058	0	Serca2	60,66	TFAM	36,40	Serca2	TFAM	29693(Tax:10116)	83474(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription .
25381816	0	Serine-arginine_protein_kinase_1	0,32	SRPK1	34,39	Serine-arginine protein kinase 1	SRPK1	6732	6732	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Serine-arginine_protein_kinase_1 -LRB- SRPK1 -RRB- inhibition as a potential novel targeted therapeutic strategy in prostate_cancer .
20943460	0	Serine_protease	0,15	HtrA1	16,21	Serine protease	HtrA1	2147	5654	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Serine_protease HtrA1 expression in human hepatocellular_carcinoma .
15795238	0	Serine_protease	0,15	serpina1	27,35	Serine protease	serpina1	2147	5265	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Serine_protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization .
24619958	0	Serine_protease_inhibitor_Kazal_type_1	0,38	EGFR	90,94	Serine protease inhibitor Kazal type 1	EGFR	6690	1956	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Serine_protease_inhibitor_Kazal_type_1 promotes epithelial-mesenchymal transition through EGFR signaling pathway in prostate_cancer .
24600488	0	Serine_threonine_kinase_Pim-3	0,29	STAT3	40,45	Serine threonine kinase Pim-3	STAT3	415116	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Serine_threonine_kinase_Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver_cancers .
22661198	0	Serotonin_2A_receptor	0,21	HTR2A	28,33	Serotonin 2A receptor	HTR2A	3356	3356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonin_2A_receptor gene -LRB- HTR2A -RRB- polymorphism in alcohol-dependent patients .
24968012	0	Serotonin_2A_receptor	0,21	HTR2A	28,33	Serotonin 2A receptor	HTR2A	3356	3356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonin_2A_receptor gene -LRB- HTR2A -RRB- regulatory variants : possible association with severity of depression symptoms in children with autism_spectrum_disorder .
21852976	0	Serotonin_Transporter	4,25	5-HTTLPR	40,48	Serotonin Transporter	5-HTTLPR	6532	6532	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	The Serotonin_Transporter Polymorphism -LRB- 5-HTTLPR -RRB- and Alcohol_Problems in Heavy Drinkers : Moderation by Depressive Symptoms .
24130607	0	Serotonin_Transporter	0,21	5-HTTLPR	36,44	Serotonin Transporter	5-HTTLPR	6532	6532	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Serotonin_Transporter Polymorphism -LRB- 5-HTTLPR -RRB- and Citalopram Effectiveness in Iranian Patients with Major_Depressive_Disorder .
24578810	0	Serotonin_Transporter	0,21	5-HTTLPR	39,47	Serotonin Transporter	5-HTTLPR	6532	6532	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Serotonin_Transporter Promoter Region -LRB- 5-HTTLPR -RRB- Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation .
26186217	0	Serotonin_Transporter	54,75	5-HTTLPR	82,90	Serotonin Transporter	5-HTTLPR	6532	6532	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Adolescent Loneliness and the Interaction between the Serotonin_Transporter Gene -LRB- 5-HTTLPR -RRB- and Parental Support : A Replication Study .
26330209	0	Serotonin_Transporter	46,67	5-HTTLPR	82,90	Serotonin Transporter	5-HTTLPR	6532	6532	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Effects of Recent Stress and Variation in the Serotonin_Transporter Polymorphism -LRB- 5-HTTLPR -RRB- on Depressive Symptoms : A Repeated-Measures Study of Adults Age 50 and Older .
26464328	0	Serotonin_Transporter	55,76	5-HTTLPR	12,20	Serotonin Transporter	5-HTTLPR	6532	6532	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|nmod|Expression	Role of the 5-HTTLPR and SNP Promoter Polymorphisms on Serotonin_Transporter Gene Expression : a Closer Look at Genetic Architecture and In Vitro Functional Studies of Common and Uncommon Allelic Variants .
25954931	0	Serotonin_Transporter	25,46	SERT	48,52	Serotonin Transporter	SERT	6532	6532	Gene	Gene	Upregulation|compound|START_ENTITY Upregulation|appos|END_ENTITY	Mechanisms of Intestinal Serotonin_Transporter -LRB- SERT -RRB- Upregulation by TGF-b1 Induced Non-Smad Pathways .
15939518	0	Serotonin_Transporter	17,38	SERTPR	62,68	Serotonin Transporter	SERTPR	6532	6532	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	The influence of Serotonin_Transporter Promoter Polymorphism -LRB- SERTPR -RRB- and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments .
25671637	0	Serotonin_Transporter	41,62	SLC6A4	69,75	Serotonin Transporter	SLC6A4	6532	6532	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Relationship of Genetic Variation in the Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- and Congenital and Acquired Cardiovascular_Diseases .
25849128	0	Serotonin_Transporter	59,80	SLC6A4	87,93	Serotonin Transporter	SLC6A4	6532	6532	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Adverse Life Events and Allele-Specific Methylation of the Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- in Adolescents : The TRAILS Study .
26573471	0	Serotonin_Transporter	21,42	SLC6A4	49,55	Serotonin Transporter	SLC6A4	6532	6532	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	-LSB- Polymorphism in the Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- and Emotional Bipolar_Disorder in Two Regional Mental Health Centers from the Eje Cafetero -LRB- Colombia -RRB- -RSB- .
26822441	0	Serotonin_Transporter	0,21	SLC6A4	28,34	Serotonin Transporter	SLC6A4	6532	6532	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Serotonin_Transporter Gene -LRB- SLC6A4 -RRB- Methylation Associates With Neonatal Intensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants .
25954931	0	Serotonin_Transporter	25,46	TGF-b1	70,76	Serotonin Transporter	TGF-b1	6532	7040	Gene	Gene	Upregulation|compound|START_ENTITY Upregulation|nmod|END_ENTITY	Mechanisms of Intestinal Serotonin_Transporter -LRB- SERT -RRB- Upregulation by TGF-b1 Induced Non-Smad Pathways .
10206229	0	Serotonin_transporter	0,21	5-HTT	28,33	Serotonin transporter	5-HTT	6532	6532	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonin_transporter gene -LRB- 5-HTT -RRB- polymorphisms and compulsive buying .
10395220	0	Serotonin_transporter	0,21	5-HTTLPR	28,36	Serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonin_transporter gene -LRB- 5-HTTLPR -RRB- is not associated with depressive symptomatology in mood_disorders .
16091117	0	Serotonin_transporter	0,21	5-HTTLPR	41,49	Serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- in patients with recurrent_aphthous_stomatitis .
17359932	0	Serotonin_transporter	0,21	5-HTTLPR	41,49	Serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- in patients with oral_lichen_planus .
18315446	0	Serotonin_transporter	0,21	5-HTTLPR	36,44	Serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin_transporter polymorphism -LRB- 5-HTTLPR -RRB- and citalopram effectiveness and side effects in children with depression and/or anxiety_disorders .
24408213	0	Serotonin_transporter	0,21	5-HTTLPR	50,58	Serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin_transporter gene promoter polymorphism -LRB- 5-HTTLPR -RRB- and alcohol use in general population : interaction effect with birth cohort .
24558768	0	Serotonin_transporter	0,21	5-HTTLPR	28,36	Serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin_transporter gene -LRB- 5-HTTLPR -RRB- polymorphism and efficacy of selective serotonin reuptake inhibitors -- do we have sufficient evidence for clinical practice .
26467894	0	Serotonin_transporter	0,21	5-HTTLPR	41,49	Serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- L allele interacts with stress to increase anxiety_symptoms in Chinese adolescents : a multiwave longitudinal study .
9878762	0	Serotonin_transporter	0,21	SERT	23,27	Serotonin transporter	SERT	25553(Tax:10116)	25553(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Serotonin_transporter -LRB- SERT -RRB- mRNA and binding site densities in male rat brain affected by sex steroids .
19487392	0	Serotonin_transporter	0,21	SLC6A4	28,34	Serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonin_transporter gene -LRB- SLC6A4 -RRB- promoter polymorphisms and the susceptibility to posttraumatic_stress_disorder in the general population .
22457857	0	Serotonin_transporter	0,21	SLC6A4	28,34	Serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonin_transporter gene -LRB- SLC6A4 -RRB- polymorphism in patients with irritable_bowel_syndrome and healthy controls .
9402979	0	Serotonin_transporter	0,21	SLC6A4	31,37	Serotonin transporter	SLC6A4	6532	6532	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Serotonin_transporter protein -LRB- SLC6A4 -RRB- allele and haplotype frequencies and linkage disequilibria in African - and European-American and Japanese populations and in alcohol-dependent subjects .
10400732	0	Serp2	13,18	granzyme_B	42,52	Serp2	granzyme B	387923	3002	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Myxoma_virus Serp2 is a weak inhibitor of granzyme_B and interleukin-1beta-converting enzyme in vitro and unlike CrmA can not block apoptosis in cowpox_virus-infected cells .
16797167	0	Serpin	2,8	protease_nexin-1	22,38	Serpin	protease nexin-1	373636(Tax:8355)	446824(Tax:8355)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A Serpin family gene , protease_nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos .
18801354	0	Serpin-28D	11,21	phenoloxidase	42,55	Serpin-28D	phenoloxidase	34091(Tax:7227)	8680162	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation .
18248459	0	SerpinA3	25,33	Nur77	79,84	SerpinA3	Nur77	12	3164	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Alpha_1-antichymotrypsin / SerpinA3 is a novel target of orphan nuclear receptor Nur77 .
21725612	0	SerpinB5	0,8	KHDRBS3	24,31	SerpinB5	KHDRBS3	5268	10656	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric_cancer cells .
24505135	0	Serpinb6b	18,27	granzyme_A	56,66	Serpinb6b	granzyme A	20708(Tax:10090)	14938(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Identification of Serpinb6b as a species-specific mouse granzyme_A inhibitor suggests functional divergence between human and mouse granzyme_A .
20676059	0	Sert	33,37	Zic2	0,4	Sert	Zic2	6532	7546	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets .
26052716	0	Serum_Amyloid_A	0,15	PKR	27,30	Serum Amyloid A	PKR	6287	5610	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Serum_Amyloid_A Stimulates PKR Expression and HMGB1 Release Possibly through TLR4/RAGE Receptors .
25738827	0	Serum_Amyloid_A3	6,22	SAA3	24,28	Serum Amyloid A3	SAA3	6290	6290	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Human Serum_Amyloid_A3 -LRB- SAA3 -RRB- Protein , Expressed as a Fusion Protein with SAA2 , Binds the Oxidized Low Density Lipoprotein Receptor .
10753626	0	Serum_amyloid_A	0,15	FPR2	44,48	Serum amyloid A	FPR2	111345(Tax:10090)	14289(Tax:10090)	Gene	Gene	agonist|nsubj|START_ENTITY agonist|nmod|END_ENTITY	Serum_amyloid_A is a chemotactic agonist at FPR2 , a low-affinity N-formylpeptide receptor on mouse neutrophils .
18952897	0	Serum_amyloid_A	0,15	G-CSF	24,29	Serum amyloid A	G-CSF	111345(Tax:10090)	12985(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Serum_amyloid_A induces G-CSF expression and neutrophilia via Toll-like_receptor_2 .
15724247	0	Serum_amyloid_A	0,15	NF-kappaB	26,35	Serum amyloid A	NF-kappaB	6287	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Serum_amyloid_A activates NF-kappaB and proinflammatory gene expression in human and murine intestinal epithelial cells .
18952897	0	Serum_amyloid_A	0,15	Toll-like_receptor_2	62,82	Serum amyloid A	Toll-like receptor 2	111345(Tax:10090)	24088(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Serum_amyloid_A induces G-CSF expression and neutrophilia via Toll-like_receptor_2 .
24476318	0	Serum_amyloid_A	0,15	Toll-like_receptor_2	64,84	Serum amyloid A	Toll-like receptor 2	6287	7097	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|fibroblasts fibroblasts|nmod|END_ENTITY	Serum_amyloid_A induces interleukin-6 in dermal fibroblasts via Toll-like_receptor_2 , interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB .
23994331	0	Serum_amyloid_A	0,15	apolipoprotein_A-I	44,62	Serum amyloid A	apolipoprotein A-I	6287	335	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	Serum_amyloid_A is independently related to apolipoprotein_A-I but not to HDL-cholesterol in patients with angina_pectoris .
17984291	0	Serum_amyloid_A	0,15	formyl_peptide_receptor_like-1	114,144	Serum amyloid A	formyl peptide receptor like-1	6287	2358	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|independent independent|nmod|END_ENTITY	Serum_amyloid_A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl_peptide_receptor_like-1 .
24476318	0	Serum_amyloid_A	0,15	interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB	86,150	Serum amyloid A	interleukin-1 receptor-associated kinase 4 and nuclear factor-kB	6287	51135	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Serum_amyloid_A induces interleukin-6 in dermal fibroblasts via Toll-like_receptor_2 , interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB .
24777946	0	Serum_amyloid_A	0,15	interleukin-33	24,38	Serum amyloid A	interleukin-33	111345(Tax:10090)	90865	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Serum_amyloid_A induces interleukin-33 expression through an IRF7-dependent pathway .
24476318	0	Serum_amyloid_A	0,15	interleukin-6	24,37	Serum amyloid A	interleukin-6	6287	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Serum_amyloid_A induces interleukin-6 in dermal fibroblasts via Toll-like_receptor_2 , interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB .
22447522	0	Serum_amyloid_A	0,15	pentraxin_3	30,41	Serum amyloid A	pentraxin 3	6287	5806	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Serum_amyloid_A -LRB- SAA -RRB- induces pentraxin_3 -LRB- PTX3 -RRB- production in rheumatoid_synoviocytes .
20853849	0	Serum_amyloid_A	0,15	peroxisome_proliferator-activated_receptor_y	26,70	Serum amyloid A	peroxisome proliferator-activated receptor y	6287	5468	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Serum_amyloid_A activates peroxisome_proliferator-activated_receptor_y through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes .
26714823	0	Serum_amyloid_A	0,15	vascular_endothelial_growth_factor_receptor_2	27,72	Serum amyloid A	vascular endothelial growth factor receptor 2	6287	3791	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Serum_amyloid_A stimulates vascular_endothelial_growth_factor_receptor_2 expression and angiogenesis .
7542869	0	Serum_amyloid_A_protein	0,23	phospholipase_A2	74,90	Serum amyloid A protein	phospholipase A2	6288	151056	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Serum_amyloid_A_protein enhances the activity of secretory non-pancreatic phospholipase_A2 .
12200418	0	Serum_response_factor	0,21	RhoA	61,65	Serum response factor	RhoA	6722	387	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|receptors receptors|nmod|END_ENTITY	Serum_response_factor activation by muscarinic receptors via RhoA .
1909174	0	Serum_response_factor	0,21	TFIID	65,70	Serum response factor	TFIID	6722	6908	Gene	Gene	affects|nsubj|START_ENTITY affects|nmod|END_ENTITY	Serum_response_factor affects preinitiation complex formation by TFIID in vitro .
22363791	0	Sestrin2	0,8	AMPK	19,23	Sestrin2	AMPK	83667	5562	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast_cancer cells .
26390293	0	Sestrin2	13,21	mTORC1	31,37	Sestrin2	mTORC1	83667	382056(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Corrigendum : Sestrin2 inhibits mTORC1 through modulation of GATOR complexes .
26390293	0	Sestrin2	13,21	mTORC1	31,37	Sestrin2	mTORC1	83667	382056(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Corrigendum : Sestrin2 inhibits mTORC1 through modulation of GATOR complexes .
26449471	0	Sestrin2	0,8	mTORC1	37,43	Sestrin2	mTORC1	83667	382056(Tax:10090)	Gene	Gene	sensor|nsubj|START_ENTITY sensor|nmod|pathway pathway|amod|END_ENTITY	Sestrin2 is a leucine sensor for the mTORC1 pathway .
26543160	0	Sestrin2	73,81	mTORC1	14,20	Sestrin2	mTORC1	83667	382056(Tax:10090)	Gene	Gene	inducing|dobj|START_ENTITY sustains|advcl|inducing sustains|dobj|suppression suppression|amod|END_ENTITY	GCN2 sustains mTORC1 suppression upon amino_acid deprivation by inducing Sestrin2 .
27010498	0	Sestrin2	37,45	mTORC1	55,61	Sestrin2	mTORC1	83667	382056(Tax:10090)	Gene	Gene	dephosphorylation|nmod|START_ENTITY promotes|nsubj|dephosphorylation promotes|dobj|activation activation|amod|END_ENTITY	Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation .
24825887	0	Sestrin2	0,8	uncoupling_protein_1	18,38	Sestrin2	uncoupling protein 1	83667	7350	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Sestrin2 inhibits uncoupling_protein_1 expression through suppressing reactive oxygen species .
20048053	0	Set2	45,49	Asf1	0,4	Set2	Asf1	853271(Tax:4932)	853327(Tax:4932)	Gene	Gene	promote|nmod|START_ENTITY promote|nsubj|END_ENTITY	Asf1 can promote trimethylation of H3 K36 by Set2 .
16314571	0	Set2	64,68	Rpb1	139,143	Set2	Rpb1	29072	5430	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1 .
18280244	0	Set7/9	22,28	p53	38,41	Set7/9	p53	73251(Tax:10090)	22060(Tax:10090)	Gene	Gene	p53|nmod|START_ENTITY Methylation|nmod|p53 mediates|nsubj|Methylation mediates|dobj|acetylation acetylation|compound|END_ENTITY	Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo .
21245319	0	Set7/9	18,24	p53	35,38	Set7/9	p53	80854	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin_1 -LRB- SIRT1 -RRB- .
25848090	0	Setd8	30,35	Gata2	46,51	Setd8	Gata2	387893	2624	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	The histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation .
26580787	0	Seven_In_Absentia_Homolog_2	46,73	SIAH2	39,44	Seven In Absentia Homolog 2	SIAH2	6478	6478	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	The Expression of the Ubiquitin Ligase SIAH2 -LRB- Seven_In_Absentia_Homolog_2 -RRB- Is Increased in Human Lung Cancer .
23645672	0	Seven_in_absentia_homolog_2	0,27	Siah2	29,34	Seven in absentia homolog 2	Siah2	6478	6478	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Seven_in_absentia_homolog_2 -LRB- Siah2 -RRB- protein is a regulator of NF-E2-related_factor_2 -LRB- Nrf2 -RRB- .
23096663	0	Sex-hormone_binding_globulin	1,29	SHBG	31,35	Sex-hormone binding globulin	SHBG	6462	6462	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	-LSB- Sex-hormone_binding_globulin -LRB- SHBG -RRB- levels during pregnancy as predictors for pre-eclampsia and fetal growth restriction -RSB- .
21220321	0	Sex-lethal	68,78	Sxl-Pe	103,109	Sex-lethal	Sxl-Pe	3772180(Tax:7227)	3772180(Tax:7227)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	The Drosophila Myc gene , diminutive , is a positive regulator of the Sex-lethal establishment promoter , Sxl-Pe .
7680770	0	Sex-lethal	12,22	U2AF	55,59	Sex-lethal	U2AF	3772180(Tax:7227)	33201(Tax:7227)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA .
19171941	0	Sex-lethal	62,72	ovarian_tumor	35,48	Sex-lethal	ovarian tumor	3772180(Tax:7227)	31789(Tax:7227)	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Effects of Wolbachia_infection and ovarian_tumor mutations on Sex-lethal germline functioning in Drosophila .
24327369	0	Sex_Hormone-Binding_Globulin	49,77	SHBG	79,83	Sex Hormone-Binding Globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single-nucleotide polymorphism , rs1799941 in the Sex_Hormone-Binding_Globulin -LRB- SHBG -RRB- gene , related to both serum testosterone and SHBG levels and the risk of myocardial_infarction , type 2 diabetes , cancer and mortality in men : the Troms Study .
26600064	0	Sex_Hormone-Binding_Globulin	23,51	SHBG	53,57	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Common Variants in the Sex_Hormone-Binding_Globulin -LRB- SHBG -RRB- Gene Influence SHBG Levels in Women with Polycystic_Ovary_Syndrome .
23599173	0	Sex_determining_region_Y-box_2	0,30	mTOR	105,109	Sex determining region Y-box 2	mTOR	6657	21977(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Sex_determining_region_Y-box_2 inhibits the proliferation of colorectal_adenocarcinoma cells through the mTOR signaling pathway .
25226295	0	Sex_hormone-binding_globulin	0,28	SHBG	30,34	Sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sex_hormone-binding_globulin -LRB- SHBG -RRB- gene expression and insulin resistance .
10369408	0	Sex_hormone_binding_globulin	0,28	estrogen_receptor	64,81	Sex hormone binding globulin	estrogen receptor	6462	2099	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Sex_hormone_binding_globulin expression and colocalization with estrogen_receptor in the human Fallopian tube .
9593910	0	Sey	73,76	Small-Eye	62,71	Sey	Small-Eye	18508(Tax:10090)	18508(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	The gonadotropin-releasing hormone system does not develop in Small-Eye -LRB- Sey -RRB- mouse phenotype .
21334315	0	Sez-6	48,53	seizure-related_gene_6	24,46	Sez-6	seizure-related gene 6	20370(Tax:10090)	20370(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The distribution of the seizure-related_gene_6 -LRB- Sez-6 -RRB- protein during postnatal development of the mouse forebrain suggests multiple functions for this protein : an analysis using a new antibody .
24451388	0	Sf1	34,37	FOXL2	0,5	Sf1	FOXL2	22668(Tax:10090)	26927(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice .
22128028	0	Sf1	46,49	Sox9	64,68	Sf1	Sox9	2516	6662	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Wnt signaling in ovarian development inhibits Sf1 activation of Sox9 via the Tesco enhancer .
12130543	0	Sf1	82,85	WT1	27,30	Sf1	WT1	7536	7490	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	The Wilms_tumor suppressor WT1 regulates early gonad development by activation of Sf1 .
11252167	0	Sf3b1	64,69	SAP155	71,77	Sf3b1	SAP155	81898(Tax:10090)	81898(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , genetic mapping , and expression of the mouse Sf3b1 -LRB- SAP155 -RRB- gene for the U2 snRNP component of spliceosome .
16425220	0	Sfrp-1	37,43	Wnt-3a	27,33	Sfrp-1	Wnt-3a	395237(Tax:9031)	395396(Tax:9031)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Differential inhibition of Wnt-3a by Sfrp-1 , Sfrp-2 , and Sfrp-3 .
15173172	0	Sftpd	94,99	surfactant_protein_D	67,87	Sftpd	surfactant protein D	20390(Tax:10090)	20390(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Nuclear factor of activated T cells regulates transcription of the surfactant_protein_D gene -LRB- Sftpd -RRB- via direct interaction with thyroid_transcription_factor-1 in lung epithelial cells .
22989713	0	Sgf11	17,22	Cbp80	70,75	Sgf11	Cbp80	40035(Tax:7227)	44409(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila .
11335130	0	Sgk	113,116	serum_and_glucocorticoid-inducible_protein_kinase	62,111	Sgk	serum and glucocorticoid-inducible protein kinase	20393(Tax:10090)	20393(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Tissue-specific expression of the transcriptionally regulated serum_and_glucocorticoid-inducible_protein_kinase -LRB- Sgk -RRB- during mouse embryogenesis .
16484615	0	Sgk-1	47,52	thrombin	154,162	Sgk-1	thrombin	20393(Tax:10090)	14061(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The serum - and glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary_vascular_remodeling : role in redox-sensitive regulation of tissue factor by thrombin .
17571248	0	Sgk1	21,25	IL-2	0,4	Sgk1	IL-2	6446	3558	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney_cancer cells .
26043694	0	Sgk1	0,4	desmoglein_1	15,27	Sgk1	desmoglein 1	20393(Tax:10090)	13510(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	Sgk1 regulates desmoglein_1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure .
24429827	0	Sgk1	0,4	pendrin	15,22	Sgk1	pendrin	20393(Tax:10090)	23985(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Sgk1 sensitive pendrin expression in murine platelets .
15871460	0	Sgkl	73,77	serum_and_glucocorticoid-inducible_kinase-like_kinase	18,71	Sgkl	serum and glucocorticoid-inducible kinase-like kinase	27219(Tax:10090)	27219(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A mutation in the serum_and_glucocorticoid-inducible_kinase-like_kinase -LRB- Sgkl -RRB- gene is associated with defective hair growth in mice .
18081426	0	Sgo1	20,24	Bub1	0,4	Sgo1	Bub1	854240(Tax:4932)	853100(Tax:4932)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis .
20808892	0	Sgs1	81,85	Cdc13	57,62	Sgs1	Cdc13	855228(Tax:4932)	851306(Tax:4932)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1 , Exo1 , and Rad9 .
23456718	0	Sgs1	32,36	Hrq1	0,4	Sgs1	Hrq1	855228(Tax:4932)	851885(Tax:4932)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Hrq1 functions independently of Sgs1 to preserve genome integrity in Saccharomyces_cerevisiae .
25637499	0	Sgs1	10,14	Rad9	20,24	Sgs1	Rad9	855228(Tax:4932)	851803(Tax:4932)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection .
6214314	0	Sgs4	94,98	glue	75,79	Sgs4	glue	31304(Tax:7227)	39288(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A complex of interacting DNAase I-hypersensitive sites near the Drosophila glue protein gene , Sgs4 .
14761955	0	Sgt1	6,10	HSP90	17,22	Sgt1	HSP90	10910	3320	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain .
17466273	0	Sgt1	25,29	Hsp70	0,5	Sgt1	Hsp70	10910	3308	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Hsp70 is a new target of Sgt1 -- an interaction modulated by S100A6 .
15340069	0	Sgt1	0,4	Hsp90	21,26	Sgt1	Hsp90	854222(Tax:4932)	855224(Tax:4932)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Sgt1 associates with Hsp90 : an initial step of assembly of the core kinetochore complex .
19131964	0	Sgt1	0,4	Hsp90	24,29	Sgt1	Hsp90	10910	3320	Gene	Gene	stabilizes|advmod|START_ENTITY stabilizes|nsubj|co-chaperone co-chaperone|nmod|END_ENTITY	Sgt1 , a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization .
22869522	0	Sgt1	20,24	Plk1	0,4	Sgt1	Plk1	10910	5347	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment .
12746458	0	Sgt1	33,37	calcyclin	51,60	Sgt1	calcyclin	10910	6277	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Calcium-regulated interaction of Sgt1 with S100A6 -LRB- calcyclin -RRB- and other S100 proteins .
26116879	0	Sh3bgr	27,33	Enah	44,48	Sh3bgr	Enah	50795(Tax:10090)	13800(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	A thioredoxin fold protein Sh3bgr regulates Enah and is necessary for proper sarcomere formation .
26116879	0	Sh3bgr	27,33	Enah	44,48	Sh3bgr	Enah	50795(Tax:10090)	13800(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	A thioredoxin fold protein Sh3bgr regulates Enah and is necessary for proper sarcomere formation .
17537256	0	Shadow_of_Prion_Protein	54,77	SPRN	79,83	Shadow of Prion Protein	SPRN	100302330(Tax:9940)	100302330(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the genomic region containing the Shadow_of_Prion_Protein -LRB- SPRN -RRB- gene in sheep .
19917049	0	Shadow_of_prion_protein	45,68	SPRN	70,74	Shadow of prion protein	SPRN	100302330(Tax:9940)	100302330(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of polymorphisms in the ovine Shadow_of_prion_protein -LRB- SPRN -RRB- gene and assessment of their effect on promoter activity and susceptibility for classical scrapie .
15448136	0	Sharp-1	0,7	DEC2	8,12	Sharp-1	DEC2	79362(Tax:10090)	79362(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	Sharp-1 / DEC2 inhibits skeletal muscle differentiation through repression of myogenic transcription factors .
24357723	0	Sharp-1	0,7	TGF-b	18,23	Sharp-1	TGF-b	79362(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	Sharp-1 regulates TGF-b signaling and skeletal muscle regeneration .
12084069	0	Shb	0,3	SLP-76	10,16	Shb	SLP-76	6461	3937	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells .
24952416	0	Shb	27,30	focal_adhesion_kinase	41,62	Shb	focal adhesion kinase	6461	5747	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	The Src homology-2 protein Shb modulates focal_adhesion_kinase signaling in a BCR-ABL myeloproliferative_disorder causing accelerated progression of disease .
10582594	0	Shc	110,113	ErbB	88,92	Shc	ErbB	20416(Tax:10090)	13649(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Neuregulin-increased expression of acetylcholine receptor epsilon-subunit gene requires ErbB interaction with Shc .
8400282	0	Shc	58,61	Erythropoietin	0,14	Shc	Erythropoietin	20416(Tax:10090)	13856(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein .
10092678	0	Shc	42,45	FRS-2	22,27	Shc	FRS-2	6464	10818	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA .
8662746	0	Shc	11,14	FcgammaRI	35,44	Shc	FcgammaRI	6464	2209	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Shc , Grb2 , and Raf-1 in FcgammaRI signal relay .
10749687	0	Shc	215,218	Grb2	227,231	Shc	Grb2	6464	2885	Gene	Gene	cytoskeleton|nmod|START_ENTITY translocation|nmod|cytoskeleton translocation|nmod|END_ENTITY	Involvement of proline-rich_tyrosine_kinase_2 in platelet activation : tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C , translocation to the cytoskeleton and association with Shc through Grb2 .
7523859	0	Shc	115,118	Grb2	90,94	Shc	Grb2	6464	2885	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc .
7523859	0	Shc	79,82	Grb2	90,94	Shc	Grb2	6464	2885	Gene	Gene	stimulate|nmod|START_ENTITY stimulate|nmod|site site|amod|END_ENTITY	Multiple cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc .
7529871	0	Shc	15,18	Grb2	54,58	Shc	Grb2	6464	2885	Gene	Gene	Interaction|nmod|START_ENTITY regulates|nsubj|Interaction regulates|dobj|association association|nmod|END_ENTITY	Interaction of Shc with Grb2 regulates association of Grb2 with mSOS .
9199344	0	Shc	0,3	Grb2	17,21	Shc	Grb2	6464	2885	Gene	Gene	contains|nsubj|START_ENTITY contains|dobj|sites sites|amod|binding binding|nmod:npmod|END_ENTITY	Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes .
9126968	0	Shc	0,3	IL-6	13,17	Shc	IL-6	6464	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase .
11278505	0	Shc	46,49	Insulin	0,7	Shc	Insulin	6464	3630	Gene	Gene	branch|compound|START_ENTITY prenyltransferases|nmod|branch signals|nmod|prenyltransferases signals|nsubj|END_ENTITY	Insulin signals to prenyltransferases via the Shc branch of intracellular signaling .
8617307	0	Shc	77,80	Interleukin-6	0,13	Shc	Interleukin-6	6464	3569	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc , and its complex formation with Grb2 in the human multiple myeloma cell line LP-1 .
9448048	0	Shc	30,33	Interleukin_5	0,13	Shc	Interleukin 5	6464	3567	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Interleukin_5 signals through Shc and Grb2 in human eosinophils .
10400627	0	Shc	0,3	JNK	64,67	Shc	JNK	6464	5599	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Shc regulates epidermal growth factor-induced activation of the JNK signaling pathway .
24795043	0	Shc	16,19	Janus_kinase_3	30,44	Shc	Janus kinase 3	6464	3718	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Adapter protein Shc regulates Janus_kinase_3 phosphorylation .
18093973	0	Shc	47,50	Protein-tyrosine_phosphatase_epsilon	0,36	Shc	Protein-tyrosine phosphatase epsilon	20416(Tax:10090)	19267(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Protein-tyrosine_phosphatase_epsilon regulates Shc signaling in a kinase-specific manner : increasing coherence in tyrosine phosphatase signaling .
9047383	0	Shc	99,102	RET	0,3	Shc	RET	6464	5979	Gene	Gene	interaction|nmod|START_ENTITY influences|dobj|interaction influences|nsubj|splicing splicing|compound|END_ENTITY	RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc , and the SH2 domain of Grb2 .
9047383	0	Shc	99,102	RET	63,66	Shc	RET	6464	5979	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc , and the SH2 domain of Grb2 .
11313948	0	Shc	121,124	Ret	154,157	Shc	Ret	6464	5979	Gene	Gene	competition|nmod|START_ENTITY evidence|nmod|competition evidence|nmod|the the|nmod|END_ENTITY	The insulin_receptor_substrate _ -LRB- IRS -RRB- -1 recruits phosphatidylinositol_3-kinase to Ret : evidence for a competition between Shc and IRS-1 for the binding to Ret .
11313948	0	Shc	121,124	Ret	81,84	Shc	Ret	6464	5979	Gene	Gene	competition|nmod|START_ENTITY evidence|nmod|competition _|dep|evidence _|amod|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|nmod|END_ENTITY	The insulin_receptor_substrate _ -LRB- IRS -RRB- -1 recruits phosphatidylinositol_3-kinase to Ret : evidence for a competition between Shc and IRS-1 for the binding to Ret .
8183561	0	Shc	64,67	Ret	30,33	Shc	Ret	6464	5979	Gene	Gene	kinases|dobj|START_ENTITY kinases|nsubj|versions versions|nmod|tyrosine tyrosine|compound|END_ENTITY	The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins .
9047384	0	Shc	18,21	Ret	38,41	Shc	Ret	6464	5979	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Identification of Shc docking site on Ret tyrosine kinase .
16257509	0	Shc	12,15	TCR	19,22	Shc	TCR	6464	6962	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Lck couples Shc to TCR signaling .
8761298	0	Shc	52,55	ZAP-70	72,78	Shc	ZAP-70	6464	7535	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation .
9677414	0	Shc	35,38	calcitonin_receptor	4,23	Shc	calcitonin receptor	6464	799	Gene	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	The calcitonin_receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation .
9480847	0	Shc	21,24	fibroblast_growth_factor_receptor-1	43,78	Shc	fibroblast growth factor receptor-1	20416(Tax:10090)	14182(Tax:10090)	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Novel recruitment of Shc , Grb2 , and Sos by fibroblast_growth_factor_receptor-1 in v-Src-transformed cells .
9490675	0	Shc	42,45	granulocyte_colony-stimulating_factor_receptor	89,135	Shc	granulocyte colony-stimulating factor receptor	6464	1441	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Proliferation signaling and activation of Shc , p21Ras , and Myc via tyrosine 764 of human granulocyte_colony-stimulating_factor_receptor .
10617282	0	Shc	149,152	insulin	107,114	Shc	insulin	6464	3630	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|pathways pathways|acl|leading leading|nmod|receptors receptors|compound|END_ENTITY	Intracellular signalling pathways of okadaic_acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors : okadaic_acid regulates Shc phosphorylation by mechanisms independent of insulin .
10617282	0	Shc	149,152	insulin	198,205	Shc	insulin	6464	3630	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nmod|mechanisms mechanisms|nmod|END_ENTITY	Intracellular signalling pathways of okadaic_acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors : okadaic_acid regulates Shc phosphorylation by mechanisms independent of insulin .
11788655	0	Shc	110,113	insulin	133,140	Shc	insulin	6464	3630	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of insulin_receptor_substrates _ -LRB- IRS -RRB- -1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes .
8621421	0	Shc	50,53	insulin	129,136	Shc	insulin	6464	3630	Gene	Gene	SH2|compound|START_ENTITY sites|nmod|SH2 mapping|nmod|sites domains|nsubj|mapping domains|nmod|receptors receptors|nmod|END_ENTITY	Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin_receptor_substrate-1 and the receptors for insulin , epidermal growth factor , platelet-derived growth factor , and fibroblast growth factor .
8702728	0	Shc	50,53	insulin	75,82	Shc	insulin	6464	3630	Gene	Gene	domain|nmod|START_ENTITY importance|nmod|domain importance|nmod|interaction interaction|nmod|receptors receptors|compound|END_ENTITY	Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner .
16170380	0	Shc	18,21	p66	14,17	Shc	p66	6464	10714	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Expression of p66 -LRB- Shc -RRB- protein correlates with proliferation of human prostate_cancer cells .
16487929	0	Shc	4,7	p66	0,3	Shc	p66	6464	10714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p66 -LRB- Shc -RRB- gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway .
25202246	0	Shc	122,125	p66	118,121	Shc	p66	20416(Tax:10090)	20416(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66 -LRB- Shc - / - -RRB- mouse .
9696394	0	Shc	102,105	p66	98,101	Shc	p66	6464	10714	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Constitutively tyrosine phosphorylated p52 Shc in breast_cancer cells : correlation with ErbB2 and p66 Shc expression .
11918806	0	Shc1p	36,41	Chs4p	69,74	Shc1p	Chs4p	856832(Tax:4932)	852218(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Control of chitin synthesis through Shc1p , a functional homologue of Chs4p specifically induced during sporulation .
20078941	0	ShcD	1,5	PTB	38,41	ShcD	PTB	399694	5725	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	-LSB- ShcD interacts with TrkC through its PTB and SH2 domains -RSB- .
20663410	0	ShcD	0,4	PTB	33,36	ShcD	PTB	399694	5725	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|TrkB TrkB|nmod|END_ENTITY	ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation .
20663410	0	ShcD	0,4	TrkB	20,24	ShcD	TrkB	399694	4915	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation .
20078941	0	ShcD	1,5	TrkC	21,25	ShcD	TrkC	399694	4916	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	-LSB- ShcD interacts with TrkC through its PTB and SH2 domains -RSB- .
16150617	0	Shh	78,81	CC10	44,48	Shh	CC10	20423(Tax:10090)	22287(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	FITC-induced murine pulmonary_inflammation : CC10 up-regulation and concurrent Shh expression .
22396494	0	Shh	110,113	Cav1	102,106	Shh	Cav1	20423(Tax:10090)	12389(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Genetic ablation of Cav1 differentially affects melanoma_tumor growth and metastasis in mice : role of Cav1 in Shh heterotypic signaling and transendothelial migration .
19934017	0	Shh	23,26	Dlx5	40,44	Shh	Dlx5	20423(Tax:10090)	13395(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft_palate in Msx1-null mice .
25455103	0	Shh	0,3	Ebf1	20,24	Shh	Ebf1	395615(Tax:9031)	395512(Tax:9031)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Shh regulates chick Ebf1 gene expression in somite development .
16481354	0	Shh	55,58	EdaR	27,31	Shh	EdaR	20423(Tax:10090)	13608(Tax:10090)	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	NF-kappaB transmits Eda_A1 / EdaR signalling to activate Shh and cyclin_D1 expression , and controls post-initiation hair placode down growth .
24415953	0	Shh	32,35	GATA6	0,5	Shh	GATA6	20423(Tax:10090)	14465(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	GATA6 is a crucial regulator of Shh in the limb bud .
12361967	0	Shh	44,47	Gli2	0,4	Shh	Gli2	20423(Tax:10090)	14633(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nmod|signaling required|nsubjpass|END_ENTITY	Gli2 , but not Gli1 , is required for initial Shh signaling and ectopic activation of the Shh pathway .
21658586	0	Shh	57,60	Lhx6	0,4	Shh	Lhx6	6469	26468	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors .
12839638	0	Shh	15,18	Ptc1	20,24	Shh	Ptc1	20423(Tax:10090)	19206(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of Shh , Ptc1 , Ptc2 mRNA in the cap stage of mouse molar -RSB- .
15380514	0	Shh	19,22	Ptc1	94,98	Shh	Ptc1	20423(Tax:10090)	19206(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY Suppression|nmod|pathway eliminates|nsubj|Suppression eliminates|dobj|medulloblastoma medulloblastoma|nmod|mice mice|amod|END_ENTITY	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 -LRB- + / - -RRB- p53 -LRB- - / - -RRB- mice .
15668330	0	Shh	23,26	Runx2	0,5	Shh	Runx2	20423(Tax:10090)	12393(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Runx2 -LRB- Cbfa1 -RRB- inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth .
24522195	0	Shh	28,31	Scube2	0,6	Shh	Scube2	6469	57758	Gene	Gene	processing|compound|START_ENTITY enhances|dobj|processing enhances|nsubj|END_ENTITY	Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells .
17961537	0	Shh	20,23	Shh	83,86	Shh	Shh	398047(Tax:8355)	398047(Tax:8355)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|region region|compound|END_ENTITY	Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians .
17961537	0	Shh	83,86	Shh	20,23	Shh	Shh	398047(Tax:8355)	398047(Tax:8355)	Gene	Gene	region|compound|START_ENTITY expression|nmod|region expression|compound|END_ENTITY	Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians .
22028618	0	Shh	42,45	Sonic_Hedgehog	26,40	Shh	Sonic Hedgehog	20423(Tax:10090)	20423(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Ectopic overexpression of Sonic_Hedgehog -LRB- Shh -RRB- induces stromal expansion and metaplasia in the adult murine pancreas .
9006067	0	Shh	31,34	Sonic_hedgehog	15,29	Shh	Sonic hedgehog	20423(Tax:10090)	20423(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Sonic_hedgehog -LRB- Shh -RRB- in mouse embryonic lung growth and morphogenesis .
20034104	0	Shh	38,41	Sox9	14,18	Shh	Sox9	6469	6662	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Sox9 by Sonic_Hedgehog -LRB- Shh -RRB- is essential for patterning and formation of tracheal cartilage .
23238718	0	Shh	83,86	Sulfatase_1	0,11	Shh	Sulfatase 1	20423(Tax:10090)	240725(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	Sulfatase_1 promotes the motor neuron-to-oligodendrocyte fate switch by activating Shh signaling in Olig2 progenitors of the embryonic ventral spinal cord .
23685334	0	Shh	40,43	Zyxin	25,30	Shh	Zyxin	398047(Tax:8355)	100049724(Tax:8355)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The cytoskeletal protein Zyxin inhibits Shh signaling during the CNS patterning in Xenopus_laevis through interaction with the transcription factor Gli1 .
15380514	0	Shh	19,22	p53	103,106	Shh	p53	20423(Tax:10090)	22060(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY Suppression|nmod|pathway eliminates|nsubj|Suppression eliminates|dobj|medulloblastoma medulloblastoma|nmod|mice mice|amod|END_ENTITY	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 -LRB- + / - -RRB- p53 -LRB- - / - -RRB- mice .
10395791	0	Shh	45,48	ptc1	18,22	Shh	ptc1	6469	5727	Gene	Gene	genes|compound|START_ENTITY induction|nmod|genes inhibits|dobj|induction inhibits|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube .
10660611	0	Ship1	31,36	erythropoietin_receptor	84,107	Ship1	erythropoietin receptor	3635	2057	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	The SH2_inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin_receptor .
20071468	0	Shoc2	60,65	Raf1	47,51	Shoc2	Raf1	8036	5894	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein .
23864681	0	Shootin1	0,8	KIF20B	30,36	Shootin1	KIF20B	71653(Tax:10090)	240641(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons .
11368516	0	Short_heterodimer_partner	0,25	aryl_hydrocarbon_receptor	97,122	Short heterodimer partner	aryl hydrocarbon receptor	8431	196	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
20858598	0	Shox2	0,5	Bmp4	43,47	Shox2	Bmp4	20429(Tax:10090)	12159(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|regulating regulating|dobj|END_ENTITY	Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart .
24347445	0	Shox2	52,57	Tbx4	0,4	Shox2	Tbx4	20429(Tax:10090)	21387(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tbx4 interacts with the short stature homeobox gene Shox2 in limb development .
11114521	0	Shp-2	33,38	RhoA	49,53	Shp-2	RhoA	5781	387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The protein tyrosine phosphatase Shp-2 regulates RhoA activity .
22878065	0	Shp-2	0,5	TrkB	20,24	Shp-2	TrkB	5781	4915	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Shp-2 regulates the TrkB receptor activity in the retinal_ganglion cells under glaucomatous stress .
10646517	0	Shp-2	0,5	brain-derived_neurotrophic_factor	73,106	Shp-2	brain-derived neurotrophic factor	25622(Tax:10116)	24225(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived_neurotrophic_factor signaling in cultured cerebral cortical neurons .
21528083	0	Shp2	9,13	E-cadherin	21,31	Shp2	E-cadherin	5781	999	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
12923167	0	Shp2	27,31	ERK	55,58	Shp2	ERK	5781	5594	Gene	Gene	phosphorylation|nmod|START_ENTITY required|nsubjpass|phosphorylation required|nmod|activation activation|compound|END_ENTITY	Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some , but not all , growth factors .
19805360	0	Shp2	25,29	ErbB	60,64	Shp2	ErbB	19247(Tax:10090)	13649(Tax:10090)	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|END_ENTITY	The tyrosine phosphatase Shp2 -LRB- PTPN11 -RRB- directs Neuregulin-1 / ErbB signaling throughout Schwann cell development .
16442778	0	Shp2	28,32	Fyn	0,3	Shp2	Fyn	19247(Tax:10090)	14360(Tax:10090)	Gene	Gene	upstream|nmod|START_ENTITY kinase|advmod|upstream kinase|nsubj|acts acts|compound|END_ENTITY	Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem_cell_factor .
22802969	0	Shp2	0,4	Fyn	15,18	Shp2	Fyn	25622(Tax:10116)	25150(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Shp2 activates Fyn and Ras to regulate RBL-2H3 mast cell activation following Fc RI_aggregation .
21528083	0	Shp2	9,13	MSH2	15,19	Shp2	MSH2	5781	4436	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
17227708	0	Shp2	12,16	PTPN11	18,24	Shp2	PTPN11	5781	5781	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of Shp2 -LRB- PTPN11 -RRB- in cancer .
24439919	0	Shp2	59,63	Src_homology_phosphotyrosyl_phosphatase_2	16,57	Shp2	Src homology phosphotyrosyl phosphatase 2	5781	5781	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of Src_homology_phosphotyrosyl_phosphatase_2 -LRB- Shp2 -RRB- expression in oral_cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro .
16959766	0	Shp2	24,28	Stat5	109,114	Shp2	Stat5	5781	6776	Gene	Gene	deletion|nmod|START_ENTITY leads|nsubj|deletion leads|nmod|activation activation|compound|END_ENTITY	Conditional deletion of Shp2 in the mammary gland leads to impaired_lobulo-alveolar_outgrowth and attenuated Stat5 activation .
23236157	0	Shp2	33,37	p38	82,85	Shp2	p38	19247(Tax:10090)	26416(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|inhibition inhibition|nmod|kinase kinase|amod|END_ENTITY	Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase .
23269672	0	Shp2	130,134	p38	69,72	Shp2	p38	19247(Tax:10090)	26416(Tax:10090)	Gene	Gene	phosphatase|dobj|START_ENTITY phosphatase|nsubj|Modulation Modulation|nmod|degradation degradation|nmod|action action|nmod|kinase kinase|amod|END_ENTITY	Modulation of fatty_acid synthase degradation by concerted action of p38 MAP kinase , E3 ligase COP1 , and SH2-tyrosine phosphatase Shp2 .
21528083	0	Shp2	9,13	p53	33,36	Shp2	p53	5781	7157	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
15031289	0	Shp2	0,4	receptor_tyrosine_kinase	75,99	Shp2	receptor tyrosine kinase	5781	5979	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Shp2 , an SH2-containing protein-tyrosine phosphatase , positively regulates receptor_tyrosine_kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty .
25553844	0	Shq1	80,84	CS	34,36	Shq1	CS	55164	54205	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|Domain Domain|compound|END_ENTITY	Structure and Interactions of the CS Domain of Human H/ACA RNP Assembly Protein Shq1 .
17666436	0	Shroom2	0,7	ZO-1	75,79	Shroom2	ZO-1	491734(Tax:9615)	403752(Tax:9615)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Shroom2 , a myosin-VIIa - and actin-binding protein , directly interacts with ZO-1 at tight junctions .
15604152	0	Shugoshin	66,75	Bub1	6,10	Shugoshin	Bub1	151648	699	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis .
25892238	0	Shugoshin-1	0,11	Aurora_B	21,29	Shugoshin-1	Aurora B	151648	9212	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	Shugoshin-1 Balances Aurora_B Kinase Activity via PP2A to Promote Chromosome Bi-orientation .
25892238	0	Shugoshin-1	0,11	PP2A	50,54	Shugoshin-1	PP2A	151648	5524	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Shugoshin-1 Balances Aurora_B Kinase Activity via PP2A to Promote Chromosome Bi-orientation .
18437680	0	Shwachman-Bodian-Diamond_syndrome	18,51	SBDS	53,57	Shwachman-Bodian-Diamond syndrome	SBDS	51119	51119	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of the Shwachman-Bodian-Diamond_syndrome -LRB- SBDS -RRB- protein in human pancreatic_cancer and chronic_pancreatitis .
25755825	0	Siah-1	20,26	synaptophysin	41,54	Siah-1	synaptophysin	6477	6855	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	E3 ubiquitin ligase Siah-1 downregulates synaptophysin expression under high glucose and hypoxia .
15326481	0	Siah-1L	0,7	beta-catenin	94,106	Siah-1L	beta-catenin	340571	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Siah-1L , a novel transcript variant belonging to the human Siah family of proteins , regulates beta-catenin activity in a p53-dependent manner .
18443365	0	Siah-1_interacting_protein	40,66	calcyclin-binding_protein	14,39	Siah-1 interacting protein	calcyclin-binding protein	27101	27101	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of calcyclin-binding_protein / Siah-1_interacting_protein in normal and malignant human tissues : an immunohistochemical survey .
14985507	0	Siah-1b	0,7	p53	46,49	Siah-1b	p53	20438(Tax:10090)	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
14985507	0	Siah-1b	0,7	p53	84,87	Siah-1b	p53	20438(Tax:10090)	7157	Gene	Gene	target|nsubj|START_ENTITY target|dep|identification identification|nmod|element element|amod|functional functional|dep|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
7895278	0	Siah-2	14,20	sina	59,63	Siah-2	sina	20439(Tax:10090)	39884(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Expression of Siah-2 , a vertebrate homologue of Drosophila sina , in germ cells of the mouse ovary and testis .
25572001	0	Siah1	17,22	HIF-1a	95,101	Siah1	HIF-1a	6477	3091	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Ubiquitin ligase Siah1 promotes the migration and invasion of human glioma cells by regulating HIF-1a signaling under hypoxia .
23645672	0	Siah2	29,34	Seven_in_absentia_homolog_2	0,27	Siah2	Seven in absentia homolog 2	6478	6478	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Seven_in_absentia_homolog_2 -LRB- Siah2 -RRB- protein is a regulator of NF-E2-related_factor_2 -LRB- Nrf2 -RRB- .
17330143	0	Sialoadhesin	0,12	CD169	14,19	Sialoadhesin	CD169	6614	6614	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sialoadhesin -LRB- CD169 -RRB- expression in CD14 + cells is upregulated early after HIV-1_infection and increases during disease progression .
11460169	0	Sic1	21,25	Cdc6	0,4	Sic1	Cdc6	850768(Tax:4932)	853244(Tax:4932)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Cdc6 cooperates with Sic1 and Hct1 to inactivate mitotic cyclin-dependent kinases .
16776651	0	Sic1	45,49	Ime2	25,29	Sic1	Ime2	850768(Tax:4932)	853338(Tax:4932)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Saccharomyces_cerevisiae Ime2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation .
16964260	0	Sic1	32,36	Pho85	4,9	Sic1	Pho85	850768(Tax:4932)	856076(Tax:4932)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage .
24823621	0	Siglec-10	96,105	IL-10	75,80	Siglec-10	IL-10	89790	16153(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|compound|END_ENTITY	Pseudaminic_acid on Campylobacter_jejuni flagella modulates dendritic cell IL-10 expression via Siglec-10 receptor : a novel flagellin-host interaction .
19861682	0	Siglec-10	6,15	vascular_adhesion_protein-1	28,55	Siglec-10	vascular adhesion protein-1	89790	8639	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	Human Siglec-10 can bind to vascular_adhesion_protein-1 and serves as its substrate .
25892023	0	Siglec-3	53,61	CD33	62,66	Siglec-3	CD33	945	945	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Molecular and functional characterization of porcine Siglec-3 / CD33 and analysis of its expression in blood and tissues .
12763136	0	Siglec-5	20,28	CD170	30,35	Siglec-5	CD170	8778	8778	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Characterization of Siglec-5 -LRB- CD170 -RRB- expression and functional activity of anti-Siglec-5 antibodies on human phagocytes .
20087405	0	Siglec-8	71,79	sialic_acid-binding_immunoglobulin-like_lectin-8	21,69	Siglec-8	sialic acid-binding immunoglobulin-like lectin-8	27181	27181	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the sialic_acid-binding_immunoglobulin-like_lectin-8 -LRB- Siglec-8 -RRB- gene are associated with susceptibility to asthma .
26923638	0	Siglec-9	25,33	CCR7	55,59	Siglec-9	CCR7	27180	1236	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Constitutively expressed Siglec-9 inhibits LPS-induced CCR7 , but enhances IL-4-induced CD200R expression in human macrophages .
18325328	0	Siglec-9	0,8	IL-10	18,23	Siglec-9	IL-10	27180	3586	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs .
20497550	0	Siglec-9	18,26	MUC16	47,52	Siglec-9	MUC16	27180	94025	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	Identification of Siglec-9 as the receptor for MUC16 on human NK cells , B cells , and monocytes .
20200274	0	Siglec-G	7,15	CD22	0,4	Siglec-G	CD22	243958(Tax:10090)	12483(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity .
17138568	0	Siglec_7	14,22	SOCS3	0,5	Siglec 7	SOCS3	27036	9021	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	SOCS3 targets Siglec_7 for proteasomal degradation and blocks Siglec_7-mediated responses .
26601948	0	Signal-transducing_Adaptor_Molecule	18,53	STAM	55,59	Signal-transducing Adaptor Molecule	STAM	8027	8027	Gene	Gene	Domain|nmod|START_ENTITY Domain|appos|END_ENTITY	The VHS Domain of Signal-transducing_Adaptor_Molecule -LRB- STAM -RRB- Directs Associated Molecule with the SH3 Domain of STAM -LRB- AMSH -RRB- Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage .
26984954	0	Signal_Transducer_and_Activator_of_Transcription_1	80,130	complement_factor_B	46,65	Signal Transducer and Activator of Transcription 1	complement factor B	6772	629	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The C-terminal tail of polycystin-1 regulates complement_factor_B expression by Signal_Transducer_and_Activator_of_Transcription_1 .
25561562	0	Signal_Transducer_and_Activator_of_Transcription_3	38,88	STAT3	90,95	Signal Transducer and Activator of Transcription 3	STAT3	6774	6774	Gene	Gene	Pathway|compound|START_ENTITY Pathway|appos|END_ENTITY	Novel Thiosemicarbazones Regulate the Signal_Transducer_and_Activator_of_Transcription_3 -LRB- STAT3 -RRB- Pathway : Inhibition of Constitutive and Interleukin_6 -LRB- IL6 -RRB- - Induced Activation by Iron Depletion .
26228595	0	Signal_Transducer_and_Activator_of_Transcription_3	51,101	STAT3	103,108	Signal Transducer and Activator of Transcription 3	STAT3	6774	6774	Gene	Gene	Pathway|compound|START_ENTITY Pathway|appos|END_ENTITY	Cardiopulmonary Bypass Decreases Activation of the Signal_Transducer_and_Activator_of_Transcription_3 -LRB- STAT3 -RRB- Pathway in Diabetic Human Myocardium .
26468894	0	Signal_Transducers_and_Activators_of_Transcription-3	161,213	Glycogen_Synthase_Kinase-3b	258,285	Signal Transducers and Activators of Transcription-3	Glycogen Synthase Kinase-3b	25125(Tax:10116)	84027(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|nmod|END_ENTITY	Remifentanil Preconditioning Reduces Postischemic_Myocardial_Infarction and Improves Left Ventricular Performance via Activation of the Janus_Activated_Kinase-2 / Signal_Transducers_and_Activators_of_Transcription-3 Signal Pathway and Subsequent Inhibition of Glycogen_Synthase_Kinase-3b in Rats .
22133921	0	Signal_Transducers_and_Activators_of_Transcription_3	61,113	Leptin	0,6	Signal Transducers and Activators of Transcription 3	Leptin	6774	3952	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Leptin promotes human glioblastoma growth through activating Signal_Transducers_and_Activators_of_Transcription_3 signaling .
23515050	0	Signal_regulatory_protein-a	0,27	insulin_receptor	47,63	Signal regulatory protein-a	insulin receptor	19261(Tax:10090)	16337(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Signal_regulatory_protein-a interacts with the insulin_receptor contributing to muscle_wasting in chronic_kidney_disease .
19223164	0	Signal_regulatory_protein_alpha	0,31	CD47	44,48	Signal regulatory protein alpha	CD47	140885	961	Gene	Gene	/|nsubj|START_ENTITY /|dobj|interaction interaction|amod|END_ENTITY	Signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- / CD47 interaction and function .
15055356	0	Signal_transducer_and_activator_of_transcription-1	0,50	IGF-I_receptor	86,100	Signal transducer and activator of transcription-1	IGF-I receptor	6772	3480	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription-1 -LRB- STAT1 -RRB- , but not STAT5b , regulates IGF-I_receptor gene expression in an osteosarcoma cell line .
22025716	0	Signal_transducer_and_activator_of_transcription-6	0,50	STAT6	52,57	Signal transducer and activator of transcription-6	STAT6	20852(Tax:10090)	20852(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription-6 -LRB- STAT6 -RRB- inhibition suppresses renal cyst growth in polycystic_kidney_disease .
21039465	0	Signal_transducer_and_activator_of_transcription_1	0,50	gamma_interferon-inducible_lysosomal_thiol_reductase	85,137	Signal transducer and activator of transcription 1	gamma interferon-inducible lysosomal thiol reductase	6772	10437	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_1 negatively regulates constitutive gamma_interferon-inducible_lysosomal_thiol_reductase expression .
19875458	0	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	52,57	Signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- mediates amino_acid inhibition of insulin signaling through serine 727 phosphorylation .
22496368	0	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	52,57	Signal transducer and activator of transcription 3	STAT3	20848(Tax:10090)	20848(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- protein suppresses adenoma-to-carcinoma transition in Apcmin / + mice via regulation of Snail-1 -LRB- SNAI -RRB- protein stability .
23733189	0	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	52,57	Signal transducer and activator of transcription 3	STAT3	20848(Tax:10090)	20848(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- degradation by proteasome controls a developmental switch in neurotrophin_dependence .
26942696	0	Signal_transducer_and_activator_of_transcription_3	0,50	STAT3	52,57	Signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- inhibitor , S3I-201 , acts as a potent and non-selective alkylating agent .
16540667	0	Signal_transducer_and_activator_of_transcription_3	0,50	epidermal_growth_factor_receptor	147,179	Signal transducer and activator of transcription 3	epidermal growth factor receptor	6774	1956	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|effects effects|nmod|mutations mutations|nmod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 is required for the oncogenic effects of non-small-cell lung_cancer-associated mutations of the epidermal_growth_factor_receptor .
21122157	0	Signal_transducer_and_activator_of_transcription_3	0,50	interleukin-6	75,88	Signal transducer and activator of transcription 3	interleukin-6	6774	3569	Gene	Gene	up-regulates|amod|START_ENTITY up-regulates|dep|production production|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 activation up-regulates interleukin-6 autocrine production : a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells .
19758315	0	Signal_transducer_and_activator_of_transcription_3	0,50	interleukin-8	63,76	Signal transducer and activator of transcription 3	interleukin-8	6774	3576	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells .
16061629	0	Signal_transducer_and_activator_of_transcription_3	0,50	telomerase_reverse_transcriptase	75,107	Signal transducer and activator of transcription 3	telomerase reverse transcriptase	6774	7015	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- regulates human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in human cancer and primary cells .
18993086	0	Signal_transducer_and_activator_of_transcription_4	0,50	T-bet	92,97	Signal transducer and activator of transcription 4	T-bet	6775	30009	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Signal_transducer_and_activator_of_transcription_4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination .
17997837	0	Signal_transducer_and_activator_of_transcription_5b	0,51	protein_tyrosine_kinase_6	89,114	Signal transducer and activator of transcription 5b	protein tyrosine kinase 6	6777	5753	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	Signal_transducer_and_activator_of_transcription_5b : a new target of breast_tumor_kinase / protein_tyrosine_kinase_6 .
23461825	0	Signal_transducer_and_activator_of_transcription_6	0,50	ORMDL3	76,82	Signal transducer and activator of transcription 6	ORMDL3	6778	94103	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Signal_transducer_and_activator_of_transcription_6 directly regulates human ORMDL3 expression .
16433852	0	Signal_transducer_and_activator_of_transcription_6	0,50	toll-like_receptor-4	66,86	Signal transducer and activator of transcription 6	toll-like receptor-4	6778	7099	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_6 down-regulates toll-like_receptor-4 expression of a monocytic cell line .
17169602	0	Signal_transducers_and_activators_of_transcription_3	0,52	vascular_endothelial_growth_factor	66,100	Signal transducers and activators of transcription 3	vascular endothelial growth factor	6774	7422	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Signal_transducers_and_activators_of_transcription_3 up-regulates vascular_endothelial_growth_factor production and tumor angiogenesis in head_and_neck_squamous_cell_carcinoma .
10986385	0	Signaling_lymphocytic_activation_molecule	0,41	Th1	86,89	Signaling lymphocytic activation molecule	Th1	6504	51497	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Signaling_lymphocytic_activation_molecule -LRB- SLAM -RRB- is differentially expressed in human Th1 and Th2 cells .
10913193	0	Sik	0,3	Sam68	25,30	Sik	Sam68	150094	10657	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Sik -LRB- BRK -RRB- phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability .
25473114	0	Sil1	0,4	BiP	39,42	Sil1	BiP	81500(Tax:10090)	14828(Tax:10090)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	Sil1 , a nucleotide exchange factor for BiP , is not required for antibody assembly or secretion .
19571399	0	Silencing_mediator_of_retinoic_acid_and_thyroid_hormone_receptor	0,64	signal_transducer_and_activator_of_transcription_3	98,148	Silencing mediator of retinoic acid and thyroid hormone receptor	signal transducer and activator of transcription 3	9612	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Silencing_mediator_of_retinoic_acid_and_thyroid_hormone_receptor regulates enhanced activation of signal_transducer_and_activator_of_transcription_3 by epstein-barr_virus-derived epstein-barr nuclear antigen 2 .
25554355	0	Silent_Information_Regulator_1	20,50	SIRT1	52,57	Silent Information Regulator 1	SIRT1	23411	23411	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between Silent_Information_Regulator_1 -LRB- SIRT1 -RRB- gene polymorphisms and schizophrenia in a Chinese Han population .
25392496	0	Sim1	10,14	Dnmt3a	0,6	Sim1	Dnmt3a	20464(Tax:10090)	13435(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Dnmt3a in Sim1 neurons is necessary for normal energy homeostasis .
24315371	0	Sim1	62,66	melanocortin_receptor_4	35,58	Sim1	melanocortin receptor 4	20464(Tax:10090)	17202(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Glutamate mediates the function of melanocortin_receptor_4 on Sim1 neurons in body weight regulation .
10915774	0	Sim2	83,87	single-minded_2	61,76	Sim2	single-minded 2	20465(Tax:10090)	20465(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mice trisomic for a bacterial artificial chromosome with the single-minded_2 gene -LRB- Sim2 -RRB- show phenotypes similar to some of those present in the partial_trisomy_16 mouse models of Down_syndrome .
16963290	0	Sim2	29,33	synapsin_I	70,80	Sim2	synapsin I	304071(Tax:10116)	24949(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of overexpression of Sim2 on spatial memory and expression of synapsin_I in rat hippocampus .
17054722	0	Sin1	0,4	ATF-2	19,24	Sin1	ATF-2	79109	1386	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway .
21104417	0	Sin3	25,29	Opi1	63,67	Sin3	Opi1	854158(Tax:4932)	856366(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Pleiotropic corepressors Sin3 and Ssn6 interact with repressor Opi1 and negatively regulate transcription of genes required for phospholipid biosynthesis in the yeast Saccharomyces_cerevisiae .
16254079	0	Sin3A	46,51	Ebp1	26,30	Sin3A	Ebp1	25942	5036	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription .
26071785	0	Single_Chain_Variable_Fragment_Antibody	18,57	scFv	59,63	Single Chain Variable Fragment Antibody	scFv	652070	652070	Gene	Gene	Construction|nmod|START_ENTITY Construction|appos|END_ENTITY	Construction of a Single_Chain_Variable_Fragment_Antibody -LRB- scFv -RRB- against Carbaryl and Its Interaction with Carbaryl .
25085976	0	Sip1	24,28	Ntf3	0,4	Sip1	Ntf3	24136(Tax:10090)	102467582	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling .
21949390	0	Sir-two-homolog_2	0,17	Par-3	84,89	Sir-two-homolog 2	Par-3	64383(Tax:10090)	112235(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Sir-two-homolog_2 -LRB- Sirt2 -RRB- modulates peripheral myelination through polarity protein Par-3 / atypical_protein_kinase_C -LRB- aPKC -RRB- signaling .
11935028	0	Sir2	70,74	Alba	19,23	Sir2	Alba	23411	173	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of Alba , a conserved archaeal chromatin protein , with Sir2 and its regulation by acetylation .
17110954	0	Sir2	41,45	Hst2	56,60	Sir2	Hst2	22933	2251	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Nuclear export modulates the cytoplasmic Sir2 homologue Hst2 .
22078933	0	SirT1	52,57	Creb	95,99	SirT1	Creb	93759(Tax:10090)	12912(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY metabolism|nmod|transgenic_mice Proatherogenic_abnormalities|nmod|metabolism mediated|nsubjpass|Proatherogenic_abnormalities mediated|nmod|deacetylation deacetylation|compound|END_ENTITY	Proatherogenic_abnormalities of lipid metabolism in SirT1 transgenic_mice are mediated through Creb deacetylation .
15469825	0	SirT1	6,11	histone_H1	27,37	SirT1	histone H1	23411	3005	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human SirT1 interacts with histone_H1 and promotes formation of facultative heterochromatin .
23292070	0	Sirt1	0,5	CREB	40,44	Sirt1	CREB	309757(Tax:10116)	81646(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Sirt1 inhibits the transcription factor CREB to regulate pituitary growth_hormone synthesis .
26626483	0	Sirt1	49,54	GAPDH	34,39	Sirt1	GAPDH	23411	2597	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation .
26714029	0	Sirt1	12,17	Insulin	28,35	Sirt1	Insulin	23411	3630	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Correction : Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells .
25940188	0	Sirt1	22,27	Sox2	0,4	Sirt1	Sox2	93759(Tax:10090)	20674(Tax:10090)	Gene	Gene	Deacetylation|nmod|START_ENTITY Deacetylation|compound|END_ENTITY	Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming .
25180292	0	Sirt1	0,5	TGF-b	26,31	Sirt1	TGF-b	93759(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Sirt1 regulates canonical TGF-b signalling to control fibroblast activation and tissue fibrosis .
16366736	0	Sirt1	0,5	UCP2	48,52	Sirt1	UCP2	93759(Tax:10090)	22228(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells .
26714029	0	Sirt1	12,17	UCP2	60,64	Sirt1	UCP2	23411	7351	Gene	Gene	Secretion|compound|START_ENTITY Secretion|nmod|END_ENTITY	Correction : Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells .
21884983	0	Sirt1	77,82	caspase-2	114,123	Sirt1	caspase-2	23411	835	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	A biotin switch-based proteomics approach identifies 14-3-3 as a target of Sirt1 in the metabolic regulation of caspase-2 .
20812964	0	Sirt1	68,73	matrix_metalloproteinase-9	38,64	Sirt1	matrix metalloproteinase-9	23411	4318	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of stress-induced matrix_metalloproteinase-9 by Sirt1 in skin tissue .
24894401	0	Sirt1	0,5	matrix_metalloproteinase-9	31,57	Sirt1	matrix metalloproteinase-9	93759(Tax:10090)	17395(Tax:10090)	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Sirt1 , a negative regulator of matrix_metalloproteinase-9 in diabetic_retinopathy .
26213858	0	Sirt1	93,98	miR-204	0,7	Sirt1	miR-204	102180824	104795766	Gene	Gene	Targeting|nmod|START_ENTITY Cells|nmod|Targeting Proliferation|nmod|Cells Regulates|dep|Proliferation Regulates|amod|END_ENTITY	miR-204 Regulates the Proliferation of Dairy Goat Spermatogonial Stem Cells via Targeting to Sirt1 .
26902620	0	Sirt1	0,5	miR-34a	95,102	Sirt1	miR-34a	93759(Tax:10090)	723848(Tax:10090)	Gene	Gene	lncRNA|compound|START_ENTITY interacts|nsubj|lncRNA interacts|nmod|mRNA mRNA|acl|inhibit inhibit|advcl|attenuating attenuating|dobj|function function|nmod|END_ENTITY	Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a .
19377286	0	Sirt1	49,54	p53	8,11	Sirt1	p53	23411	7157	Gene	Gene	inhibition|amod|START_ENTITY effects|nmod|inhibition Role|nmod|effects Role|nmod|END_ENTITY	Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate_cancer cells .
22542455	0	Sirt1	69,74	p53	18,21	Sirt1	p53	93759(Tax:10090)	22060(Tax:10090)	Gene	Gene	deubiquitinating|dobj|START_ENTITY antagonizes|advcl|deubiquitinating antagonizes|dobj|activation activation|nummod|END_ENTITY	USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development .
26902357	0	Sirt1	0,5	p53	16,19	Sirt1	p53	309757(Tax:10116)	301300(Tax:10116)	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus .
22493735	0	Sirt1	0,5	resistin	15,23	Sirt1	resistin	23411	56729	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Sirt1 inhibits resistin expression in aortic_stenosis .
16211212	0	Sirt2	96,101	Sirtuin_2	85,94	Sirt2	Sirtuin 2	22933	22933	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene , Sirtuin_2 -LRB- Sirt2 -RRB- .
22732184	0	Sirt3	59,64	MnSOD	78,83	Sirt3	MnSOD	23410	6648	Gene	Gene	role|nmod|START_ENTITY Exploring|nmod|role Exploring|advcl|directing directing|dobj|status status|amod|END_ENTITY	Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity .
23886445	0	Sirt3	42,47	MnSOD	14,19	Sirt3	MnSOD	23410	6648	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis .
23142079	0	Sirt6	16,21	GCN5	54,58	Sirt6	GCN5	50721(Tax:10090)	14534(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis .
23108666	0	Sirtuin-3	0,9	Bak	20,23	Sirtuin-3	Bak	23410	578	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Sirtuin-3 modulates Bak - and Bax-dependent apoptosis .
23871415	0	Sirtuin-3	0,9	SIRT3	11,16	Sirtuin-3	SIRT3	23410	23410	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sirtuin-3 -LRB- SIRT3 -RRB- expression is associated with overall survival in esophageal_cancer .
25759382	0	Sirtuin-3	0,9	SIRT3	11,16	Sirtuin-3	SIRT3	64384(Tax:10090)	64384(Tax:10090)	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Sirtuin-3 -LRB- SIRT3 -RRB- Protein Attenuates Doxorubicin-induced Oxidative Stress and Improves Mitochondrial Respiration in H9c2 Cardiomyocytes .
22807441	0	Sirtuin_1	54,63	CREB-binding_protein	33,53	Sirtuin 1	CREB-binding protein	23411	1387	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	The acetylase/deacetylase couple CREB-binding_protein / Sirtuin_1 controls hypoxia-inducible factor 2 signaling .
16257164	0	Sirtuin_1	0,9	SIRT1	11,16	Sirtuin 1	SIRT1	23411	23411	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- sequence variation is not associated with exceptional human longevity .
20339025	0	Sirtuin_1	25,34	SIRT1	8,13	Sirtuin 1	SIRT1	23411	23411	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Lack of SIRT1 -LRB- Mammalian Sirtuin_1 -RRB- activity leads to liver_steatosis in the SIRT1 + / - mice : a role of lipid mobilization and inflammation .
21540183	0	Sirtuin_1	0,9	SIRT1	11,16	Sirtuin 1	SIRT1	93759(Tax:10090)	93759(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- protein degradation in response to persistent c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation contributes to hepatic_steatosis in obesity .
24466304	0	Sirtuin_1	0,9	SIRT1	11,16	Sirtuin 1	SIRT1	93759(Tax:10090)	93759(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice .
26656366	0	Sirtuin_1	39,48	SIRT1	50,55	Sirtuin 1	SIRT1	23411	23411	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Single Nucleotide Polymorphisms of the Sirtuin_1 -LRB- SIRT1 -RRB- Gene are Associated With age-Related Macular_Degeneration in Chinese Han Individuals : A Case-Control Pilot Study .
22984430	0	Sirtuin_1	0,9	SREBP-1c	20,28	Sirtuin 1	SREBP-1c	93759(Tax:10090)	20787(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Sirtuin_1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle .
17505061	0	Sirtuin_1	0,9	androgen_receptor	108,125	Sirtuin 1	androgen receptor	23411	367	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Sirtuin_1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen_receptor .
21386086	0	Sirtuin_1	12,21	p53	22,25	Sirtuin 1	p53	93759(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|essential essential|nsubj|END_ENTITY	The central Sirtuin_1 / p53 pathway is essential for the orexigenic action of ghrelin .
25275824	0	Sirtuin_2	34,43	SIRT2	45,50	Sirtuin 2	SIRT2	22933	22933	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of Potent and Selective Sirtuin_2 -LRB- SIRT2 -RRB- Inhibitors Using a Fragment-Based Approach .
16211212	0	Sirtuin_2	85,94	Sirt2	96,101	Sirtuin 2	Sirt2	22933	22933	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene , Sirtuin_2 -LRB- Sirt2 -RRB- .
25128872	0	Sirtuin_3	0,9	Lon_protease	25,37	Sirtuin 3	Lon protease	23410	9361	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sirtuin_3 interacts with Lon_protease and regulates its acetylation status .
20661474	0	Sirtuin_3	0,9	PGC-1alpha	27,37	Sirtuin 3	PGC-1alpha	23410	10891	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Sirtuin_3 , a new target of PGC-1alpha , plays an important role in the suppression of ROS and mitochondrial biogenesis .
24121500	0	Sirtuin_3	0,9	SIRT3	11,16	Sirtuin 3	SIRT3	64384(Tax:10090)	64384(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Sirtuin_3 -LRB- SIRT3 -RRB- protein regulates long-chain_acyl-CoA_dehydrogenase by deacetylating conserved lysines near the active site .
24163442	0	Sirtuin_6	27,36	SIRT6	38,43	Sirtuin 6	SIRT6	51548	51548	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	A proteomic perspective of Sirtuin_6 -LRB- SIRT6 -RRB- phosphorylation and interactions and their dependence on its catalytic activity .
17181175	0	Sirtuin_Type_2	91,105	SIRT2	107,112	Sirtuin Type 2	SIRT2	22933	22933	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	N , N ' - Bisbenzylidenebenzene-1 ,4 - diamines and N , N ' - Bisbenzylidenenaphthalene-1 ,4 - diamines as Sirtuin_Type_2 -LRB- SIRT2 -RRB- Inhibitors .
26875984	0	Site_1_Protease	27,42	S1P	44,47	Site 1 Protease	S1P	8720	8720	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|appos|END_ENTITY	Suppressive Effects of the Site_1_Protease -LRB- S1P -RRB- Inhibitor , PF-429242 , on Dengue_Virus_Propagation .
10597319	0	Siva	62,66	CD27	86,90	Siva	CD27	30954(Tax:10090)	21940(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY forms|nmod|gene Siva-1|appos|forms Siva-1|appos|apoptosis apoptosis|compound|bind bind|nmod|END_ENTITY	Murine Siva-1 and Siva-2 , alternate splice forms of the mouse Siva gene , both bind to CD27 but differentially transduce apoptosis .
9177220	0	Siva	92,96	CD27	0,4	Siva	CD27	10572	939	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	CD27 , a member of the tumor necrosis factor receptor family , induces apoptosis and binds to Siva , a proapoptotic protein .
21955384	0	Siva	38,42	IL-2	14,18	Siva	IL-2	10572	3558	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells .
17464332	0	Siva	0,4	p53	31,34	Siva	p53	10572	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Siva is an apoptosis-selective p53 target gene important for neuronal cell death .
18849585	0	Siva	21,25	telethonin	54,64	Siva	telethonin	10572	8557	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection .
24451137	0	Siva-1	18,24	Egr-1	0,5	Siva-1	Egr-1	10572	1958	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Egr-1 upregulates Siva-1 expression and induces cardiac fibroblast apoptosis .
16491128	0	Siva-1	0,6	NF-kappaB	28,37	Siva-1	NF-kappaB	10572	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Siva-1 negatively regulates NF-kappaB activity : effect on T-cell receptor-mediated activation-induced cell death -LRB- AICD -RRB- .
20727854	0	Siva-1	58,64	Tyrosine_kinase_2	0,17	Siva-1	Tyrosine kinase 2	30954(Tax:10090)	54721(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tyrosine_kinase_2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions .
23462994	0	Siva1	0,5	p53	15,18	Siva1	p53	10572	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|compound|END_ENTITY	Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase .
21281623	0	Six1	0,4	Grem1	15,20	Six1	Grem1	20471(Tax:10090)	23892(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis .
23840772	0	Six1	0,4	MyoD	15,19	Six1	MyoD	20471(Tax:10090)	17927(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Six1 regulates MyoD expression in adult muscle progenitor cells .
25458011	0	Six2	20,24	Eya1	0,4	Six2	Eya1	10736	2138	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	Eya1 Interacts with Six2 and Myc to Regulate Expansion of the Nephron Progenitor Pool during Nephrogenesis .
15634706	0	Six2	20,24	Hoxa2	0,5	Six2	Hoxa2	10736	3199	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme .
25187057	0	Six2	101,105	miR181c	0,7	Six2	miR181c	10736	406957	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR181c promotes apoptosis and suppresses proliferation of metanephric mesenchyme cells by targeting Six2 in vitro .
10704858	0	Six3	65,69	xSix3	26,31	Six3	xSix3	20473(Tax:10090)	373739(Tax:8355)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Cloning and expression of xSix3 , the Xenopus homologue of murine Six3 .
17084678	0	Six3OS	36,42	Six3_Opposite_Strand	14,34	Six3OS	Six3 Opposite Strand	100043902(Tax:10090)	100043902(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Six3_Opposite_Strand -LRB- Six3OS -RRB- during mouse embryonic development .
17084678	0	Six3_Opposite_Strand	14,34	Six3OS	36,42	Six3 Opposite Strand	Six3OS	100043902(Tax:10090)	100043902(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Six3_Opposite_Strand -LRB- Six3OS -RRB- during mouse embryonic development .
15282156	0	Six5	94,98	UNC-39	0,6	Six5	UNC-39	147912	191623(Tax:6239)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	UNC-39 , the C. _ elegans homolog of the human myotonic_dystrophy-associated homeodomain protein Six5 , regulates cell motility and differentiation .
12193603	0	Siz2	75,79	TFII-I	114,120	Siz2	TFII-I	9063	2969	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta / Siz2 is a transcriptional cofactor for TFII-I .
26797278	0	Ska1	0,4	DDA3	21,25	Ska1	DDA3	220134	84722	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Ska1 cooperates with DDA3 for spindle dynamics and spindle attachment to kinetochore .
22334647	0	Ski	14,17	Satb2	66,71	Ski	Satb2	6497	23314	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Protooncogene Ski cooperates with the chromatin-remodeling factor Satb2 in specifying callosal neurons .
22843506	0	Ski	48,51	Sloan-Kettering_Institute	21,46	Ski	Sloan-Kettering Institute	6497	6497	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Differential role of Sloan-Kettering_Institute -LRB- Ski -RRB- protein in Nodal and transforming_growth_factor-beta -LRB- TGF-b -RRB- - induced Smad signaling in prostate_cancer cells .
23566155	0	Ski-interacting_protein	0,23	androgen_receptor	46,63	Ski-interacting protein	androgen receptor	22938	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ski-interacting_protein -LRB- SKIP -RRB- interacts with androgen_receptor in the nucleus and modulates androgen-dependent transcription .
9569025	0	Ski_oncoprotein	4,19	Skip	35,39	Ski oncoprotein	Skip	6497	22938	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Ski_oncoprotein interacts with Skip , the human homolog of Drosophila Bx42 .
9569025	0	Skip	35,39	Bx42	73,77	Skip	Bx42	22938	31840(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	The Ski_oncoprotein interacts with Skip , the human homolog of Drosophila Bx42 .
9569025	0	Skip	35,39	Ski_oncoprotein	4,19	Skip	Ski oncoprotein	22938	6497	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Ski_oncoprotein interacts with Skip , the human homolog of Drosophila Bx42 .
24428937	0	Skn-1a	0,6	Pou2f3	7,13	Skn-1a	Pou2f3	18988(Tax:10090)	18988(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	Skn-1a / Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium .
21378169	0	Skp1	40,44	CRM1	61,65	Skp1	CRM1	6500	7514	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	A Competitive binding mechanism between Skp1 and exportin_1 -LRB- CRM1 -RRB- controls the localization of a subset of F-box proteins .
22205987	0	Skp1	96,100	NIPA	54,58	Skp1	NIPA	6500	51530	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	APC/C -LRB- Cdh1 -RRB- - mediated degradation of the F-box protein NIPA is regulated by its association with Skp1 .
18718460	0	Skp1	20,24	SKR-1	0,5	Skp1	SKR-1	179598(Tax:6239)	172775(Tax:6239)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	SKR-1 , a homolog of Skp1 and a member of the SCF -LRB- SEL-10 -RRB- complex , regulates sex-determination and LIN-12 / Notch signaling in C. _ elegans .
23027877	0	Skp1-Cul1-F-box	0,15	bTrCP	38,43	Skp1-Cul1-F-box	bTrCP	4254;6500	8945	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Skp1-Cul1-F-box ubiquitin ligase -LRB- SCF -LRB- bTrCP -RRB- -RRB- - mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry .
19270694	0	Skp2	89,93	Akt/PKB	97,104	Skp2	Akt/PKB	6502	207	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB .
26697838	0	Skp2	0,4	Aurora_B	21,29	Skp2	Aurora B	6502	9212	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Skp2 is required for Aurora_B activation in cell mitosis and spindle checkpoint .
15833859	0	Skp2	34,38	BCR-ABL	0,7	Skp2	BCR-ABL	6502	25	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic_myelogenous_leukemia cells .
24269842	0	Skp2	34,38	Cdk2	57,61	Skp2	Cdk2	27401(Tax:10090)	12566(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	p27 is regulated independently of Skp2 in the absence of Cdk2 .
23352642	0	Skp2	35,39	E2F1	76,80	Skp2	E2F1	6502	1869	Gene	Gene	START_ENTITY|acl|activating activating|dobj|END_ENTITY	The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast_cancer cells .
15668399	0	Skp2	0,4	FOXO1	14,19	Skp2	FOXO1	27401(Tax:10090)	56458(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation .
15766658	0	Skp2	0,4	FoxO1	10,15	Skp2	FoxO1	6502	2308	Gene	Gene	START_ENTITY|appos|hunter hunter|amod|END_ENTITY	Skp2 , the FoxO1 hunter .
11818378	0	Skp2	40,44	KIP1	19,23	Skp2	KIP1	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|nsubj|Involvement Involvement|nmod|p27 p27|appos|END_ENTITY	Involvement of p27 -LRB- KIP1 -RRB- degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium .
14707456	0	Skp2	0,4	KIP1	71,75	Skp2	KIP1	6502	1027	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|nmod|p27 p27|appos|END_ENTITY	Skp2 and Jab1 expression are associated with inverse expression of p27 -LRB- KIP1 -RRB- and poor prognosis in oral_squamous_cell_carcinomas .
14734747	0	Skp2	113,117	KIP1	58,62	Skp2	KIP1	6502	1027	Gene	Gene	transcription|amod|START_ENTITY inhibition|nmod|transcription mediated|nmod|inhibition arrest|acl|mediated regulation|dep|arrest regulation|dep|p27 p27|appos|END_ENTITY	Nuclear pro-IL-16 regulation of T cell proliferation : p27 -LRB- KIP1 -RRB- - dependent G0/G1 arrest mediated by inhibition of Skp2 transcription .
10375532	0	Skp2	65,69	Kip1	4,8	Skp2	Kip1	6502	1027	Gene	Gene	complex|appos|START_ENTITY regulated|nmod|complex regulated|nsubjpass|ubiquitination ubiquitination|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
11335900	0	Skp2	81,85	Kip1	39,43	Skp2	Kip1	6502	1027	Gene	Gene	ligase|dobj|START_ENTITY ligase|nsubj|relation relation|nmod|levels levels|nmod|p27 p27|appos|END_ENTITY	Inverse relation between levels of p27 -LRB- Kip1 -RRB- and of its ubiquitin ligase subunit Skp2 in colorectal_carcinomas .
12351407	0	Skp2	14,18	Kip1	26,30	Skp2	Kip1	6502	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|ligase ligase|appos|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	Skp2	14,18	Kip1	94,98	Skp2	Kip1	6502	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
16209941	0	Skp2	75,79	Kip1	58,62	Skp2	Kip1	6502	1027	Gene	Gene	ubiquitin|appos|START_ENTITY END_ENTITY|nmod|ubiquitin	Structural basis of the Cks1-dependent recognition of p27 -LRB- Kip1 -RRB- by the SCF -LRB- Skp2 -RRB- ubiquitin ligase .
17384652	0	Skp2	0,4	Kip1	73,77	Skp2	Kip1	6502	1027	Gene	Gene	prognosticator|nsubj|START_ENTITY prognosticator|nmod|gallbladder_carcinoma gallbladder_carcinoma|nmod|p27 p27|appos|END_ENTITY	Skp2 is an independent prognosticator of gallbladder_carcinoma among p27 -LRB- Kip1 -RRB- - interacting cell cycle regulators : an immunohistochemical study of 62 cases by tissue microarray .
19724954	0	Skp2	28,32	Kip1	41,45	Skp2	Kip1	6502	1027	Gene	Gene	correlation|nmod|START_ENTITY correlation|appos|END_ENTITY	Inverse correlation between Skp2 and p27 -LRB- Kip1 -RRB- in normal endometrium and endometrial_carcinoma .
21299246	0	Skp2	139,143	Kip1	133,137	Skp2	Kip1	6502	1027	Gene	Gene	complex|dep|START_ENTITY p27|dep|complex p27|appos|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21299246	0	Skp2	139,143	Kip1	95,99	Skp2	Kip1	6502	1027	Gene	Gene	complex|dep|START_ENTITY p27|dep|complex disruption|nmod|p27 attributed|nmod|disruption END_ENTITY|acl|attributed	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
23474082	0	Skp2	0,4	Kip1	72,76	Skp2	Kip1	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY inhibits|nsubj|deficiency inhibits|xcomp|independent independent|nmod|accumulation accumulation|appos|END_ENTITY	Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27 -LRB- Kip1 -RRB- accumulation .
26682002	0	Skp2	107,111	Kip1	44,48	Skp2	Kip1	6502	1027	Gene	Gene	Downregulation|compound|START_ENTITY Affecting|nmod|Downregulation Increase|advcl|Affecting Increase|dobj|p27 p27|appos|END_ENTITY	Histone Deacetylase Inhibitors Increase p27 -LRB- Kip1 -RRB- by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation .
19625121	0	Skp2	0,4	MMP-2	48,53	Skp2	MMP-2	6502	4313	Gene	Gene	overexpression|amod|START_ENTITY increases|nsubj|overexpression increases|dobj|expression expression|nmod|END_ENTITY	Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung_cancer cells .
26874697	0	Skp2	0,4	MMP-2	33,38	Skp2	MMP-2	6502	4313	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|nmod|END_ENTITY	Skp2 Regulates the Expression of MMP-2 and MMP-9 , and Enhances the Invasion Potential of Oral_Squamous_Cell_Carcinoma .
17652624	0	Skp2	5,9	MYCN	75,79	Skp2	MYCN	6502	4613	Gene	Gene	expression|amod|START_ENTITY characterizes|nsubj|expression characterizes|xcomp|independent independent|nmod|status status|compound|END_ENTITY	High Skp2 expression characterizes high-risk neuroblastomas independent of MYCN status .
26482610	0	Skp2	0,4	Meg3	57,61	Skp2	Meg3	6502	55384	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Skp2 regulates non-small_cell_lung_cancer cell growth by Meg3 and miR-3163 .
15363035	0	Skp2	29,33	P27	84,87	Skp2	P27	6502	10671	Gene	Gene	study|nmod|START_ENTITY study|appos|molecules molecules|nmod|degradation degradation|nmod|END_ENTITY	Immunohistochemical study of Skp2 and Jab1 , two key molecules in the degradation of P27 , in lung_adenocarcinoma .
16405750	0	Skp2	16,20	P27	70,73	Skp2	P27	6502	10534	Gene	Gene	expression|amod|START_ENTITY Correlation|nmod|expression Correlation|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Correlation of Skp2 expression in gastric_carcinoma to expression of P27 and PTEN -RSB- .
16425184	0	Skp2	54,58	PC3	62,65	Skp2	PC3	6502	5122	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
23939428	0	Skp2	0,4	PPARy	43,48	Skp2	PPARy	6502	5468	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Skp2 regulates subcellular localization of PPARy by MEK signaling pathways in human breast_cancer .
12408227	0	Skp2	93,97	PTEN	113,117	Skp2	PTEN	6502	5728	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells .
10375532	0	Skp2	65,69	SCF	61,64	Skp2	SCF	6502	4254	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
15093536	0	Skp2	78,82	SCF	74,77	Skp2	SCF	6502	4254	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Crashing waves of destruction : the cell cycle and APC -LRB- Cdh1 -RRB- regulation of SCF -LRB- Skp2 -RRB- .
20407011	0	Skp2	16,20	STAT1	0,5	Skp2	STAT1	6502	6772	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells .
22252296	0	Skp2	24,28	Stat3	0,5	Skp2	Stat3	6502	6774	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Stat3 induces oncogenic Skp2 expression in human cervical_carcinoma cells .
26038816	0	Skp2	134,138	TRUSS	33,38	Skp2	TRUSS	6502	26133	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2 .
24347472	0	Skp2	0,4	androgen_receptor	15,32	Skp2	androgen receptor	6502	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Skp2 regulates androgen_receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate_cancer .
26939395	0	Skp2	22,26	androgen_receptor	72,89	Skp2	androgen receptor	6502	367	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Regulatory effect of Skp2 on the expression and transactivation of the androgen_receptor in the progression of castration-resistant_prostate_cancer -RSB- .
24561244	0	Skp2	10,14	b-catenin	25,34	Skp2	b-catenin	6502	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	E3-ligase Skp2 regulates b-catenin expression and maintains hematopoietic stem cell homing .
21251405	0	Skp2	15,19	c-myc	45,50	Skp2	c-myc	6502	4609	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of Skp2 and its correlation with c-myc in non-small_cell_lung_cancer -RSB- .
16425184	0	Skp2	54,58	kip1	33,37	Skp2	kip1	6502	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
18953829	0	Skp2	42,46	kip1	55,59	Skp2	kip1	6502	1027	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	-LSB- Expression variation and significance of Skp2 and p27 -LRB- kip1 -RRB- during the proliferation of Jurkat cells -RSB- .
10375532	0	Skp2	65,69	p27	0,3	Skp2	p27	6502	10671	Gene	Gene	complex|appos|START_ENTITY regulated|nmod|complex regulated|nsubjpass|ubiquitination ubiquitination|amod|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
10375532	0	Skp2	65,69	p27	112,115	Skp2	p27	6502	10671	Gene	Gene	complex|appos|START_ENTITY complex|nmod|Thr187 Thr187|nmod|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
11231585	0	Skp2	59,63	p27	94,97	Skp2	p27	6502	10671	Gene	Gene	SCF|appos|START_ENTITY SCF|dep|ubiquitinylation ubiquitinylation|nmod|END_ENTITY	The cell-cycle regulatory protein Cks1 is required for SCF -LRB- Skp2 -RRB- - mediated ubiquitinylation of p27 .
11335900	0	Skp2	81,85	p27	35,38	Skp2	p27	6502	10671	Gene	Gene	ligase|dobj|START_ENTITY ligase|nsubj|relation relation|nmod|levels levels|nmod|END_ENTITY	Inverse relation between levels of p27 -LRB- Kip1 -RRB- and of its ubiquitin ligase subunit Skp2 in colorectal_carcinomas .
11738146	0	Skp2	112,116	p27	27,30	Skp2	p27	6502	10671	Gene	Gene	expression|nmod|START_ENTITY correlates|nmod|expression correlates|nsubj|stabilization stabilization|nmod|END_ENTITY	Metabolic stabilization of p27 in senescent fibroblasts correlates with reduced expression of the F-box protein Skp2 .
11818378	0	Skp2	40,44	p27	15,18	Skp2	p27	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of p27 -LRB- KIP1 -RRB- degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium .
12097295	0	Skp2	158,162	p27	192,195	Skp2	p27	6502	10534	Gene	Gene	overexpression|amod|START_ENTITY phenotype|nmod|overexpression modulation|nmod|phenotype significance|dep|modulation significance|nmod|proteolysis proteolysis|amod|END_ENTITY	Clinical and biological significance of S-phase_kinase-associated_protein_2 -LRB- Skp2 -RRB- gene expression in gastric_carcinoma : modulation of malignant phenotype by Skp2 overexpression , possibly via p27 proteolysis .
12097295	0	Skp2	77,81	p27	192,195	Skp2	p27	6502	10534	Gene	Gene	S-phase_kinase-associated_protein_2|dep|START_ENTITY expression|amod|S-phase_kinase-associated_protein_2 significance|nmod|expression significance|nmod|proteolysis proteolysis|amod|END_ENTITY	Clinical and biological significance of S-phase_kinase-associated_protein_2 -LRB- Skp2 -RRB- gene expression in gastric_carcinoma : modulation of malignant phenotype by Skp2 overexpression , possibly via p27 proteolysis .
12351407	0	Skp2	14,18	p27	22,25	Skp2	p27	6502	10671	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|ligase ligase|amod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	Skp2	14,18	p27	90,93	Skp2	p27	6502	10671	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|Kip1 Kip1|amod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12408227	0	Skp2	93,97	p27	84,87	Skp2	p27	6502	10534	Gene	Gene	independent|amod|START_ENTITY diminish|nmod|independent diminish|dobj|association association|nmod|END_ENTITY	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells .
12429629	0	Skp2	9,13	p27	122,125	Skp2	p27	6502	10671	Gene	Gene	expression|amod|START_ENTITY expression|dep|association association|nmod|loss loss|nmod|END_ENTITY	Elevated Skp2 protein expression in human prostate_cancer : association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival .
12704665	0	Skp2	18,22	p27	84,87	Skp2	p27	6502	10671	Gene	Gene	Overexpression|nmod|START_ENTITY correlate|nsubj|Overexpression correlate|nmod|expression expression|amod|END_ENTITY	Overexpression of Skp2 in carcinoma_of_the_cervix does not correlate inversely with p27 expression .
14558671	0	Skp2	36,40	p27	71,74	Skp2	p27	6502	10671	Gene	Gene	expression|nmod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|amod|END_ENTITY	The expression of the F-box protein Skp2 is negatively associated with p27 expression in human pituitary_tumors .
14707456	0	Skp2	0,4	p27	67,70	Skp2	p27	6502	10534	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|nmod|END_ENTITY	Skp2 and Jab1 expression are associated with inverse expression of p27 -LRB- KIP1 -RRB- and poor prognosis in oral_squamous_cell_carcinomas .
14734747	0	Skp2	113,117	p27	54,57	Skp2	p27	6502	10671	Gene	Gene	transcription|amod|START_ENTITY inhibition|nmod|transcription mediated|nmod|inhibition arrest|acl|mediated regulation|dep|arrest regulation|dep|END_ENTITY	Nuclear pro-IL-16 regulation of T cell proliferation : p27 -LRB- KIP1 -RRB- - dependent G0/G1 arrest mediated by inhibition of Skp2 transcription .
15161026	0	Skp2	86,90	p27	49,52	Skp2	p27	6502	10671	Gene	Gene	ligase|dobj|START_ENTITY ligase|nsubj|correlation correlation|nmod|levels levels|nmod|END_ENTITY	Inverse correlation between expression levels of p27 and the ubiquitin ligase subunit Skp2 in early esophageal_squamous_cell_carcinoma .
15351619	0	Skp2	51,55	p27	14,17	Skp2	p27	6502	10671	Gene	Gene	ligase|dobj|START_ENTITY ligase|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p27 and its ubiquitin ligase subunit Skp2 in upper urinary_tract_transitional_cell_carcinoma .
15579456	0	Skp2	79,83	p27	97,100	Skp2	p27	6502	10671	Gene	Gene	START_ENTITY|acl|promoting promoting|dobj|degradation degradation|amod|END_ENTITY	Role of Cks1 overexpression in oral_squamous_cell_carcinomas : cooperation with Skp2 in promoting p27 degradation .
16209941	0	Skp2	75,79	p27	54,57	Skp2	p27	6502	10671	Gene	Gene	ubiquitin|appos|START_ENTITY Kip1|nmod|ubiquitin Kip1|amod|END_ENTITY	Structural basis of the Cks1-dependent recognition of p27 -LRB- Kip1 -RRB- by the SCF -LRB- Skp2 -RRB- ubiquitin ligase .
16425184	0	Skp2	54,58	p27	29,32	Skp2	p27	6502	10671	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
17384652	0	Skp2	0,4	p27	69,72	Skp2	p27	6502	10671	Gene	Gene	prognosticator|nsubj|START_ENTITY prognosticator|nmod|gallbladder_carcinoma gallbladder_carcinoma|nmod|END_ENTITY	Skp2 is an independent prognosticator of gallbladder_carcinoma among p27 -LRB- Kip1 -RRB- - interacting cell cycle regulators : an immunohistochemical study of 62 cases by tissue microarray .
17431674	0	Skp2	0,4	p27	54,57	Skp2	p27	6502	10671	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|down-regulation down-regulation|nmod|protein protein|amod|END_ENTITY	Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid_cystic_carcinoma .
17475922	0	Skp2	68,72	p27	39,42	Skp2	p27	6502	10671	Gene	Gene	ligase|dobj|START_ENTITY ligase|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells .
18305219	0	Skp2	32,36	p27	14,17	Skp2	p27	6502	10671	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Targeting the p27 E3 ligase SCF -LRB- Skp2 -RRB- results in p27 - and Skp2-mediated cell-cycle arrest and activation of autophagy .
18305219	0	Skp2	32,36	p27	49,52	Skp2	p27	6502	10671	Gene	Gene	results|appos|START_ENTITY results|nmod|arrest arrest|amod|END_ENTITY	Targeting the p27 E3 ligase SCF -LRB- Skp2 -RRB- results in p27 - and Skp2-mediated cell-cycle arrest and activation of autophagy .
18604603	0	Skp2	0,4	p27	31,34	Skp2	p27	6502	10671	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Skp2 inversely correlates with p27 and tuberin in transformed cells .
19364496	0	Skp2	20,24	p27	0,3	Skp2	p27	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	overexpression|amod|START_ENTITY deregulation|nmod|overexpression deregulation|amod|END_ENTITY	p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation .
21299246	0	Skp2	139,143	p27	129,132	Skp2	p27	6502	10671	Gene	Gene	complex|dep|START_ENTITY END_ENTITY|dep|complex	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21299246	0	Skp2	139,143	p27	91,94	Skp2	p27	6502	10671	Gene	Gene	complex|dep|START_ENTITY p27|dep|complex disruption|nmod|p27 attributed|nmod|disruption Kip1|acl|attributed Kip1|amod|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
22484732	0	Skp2	84,88	p27	41,44	Skp2	p27	6502	10671	Gene	Gene	regulation|nmod|START_ENTITY enhances|nmod|regulation enhances|dobj|stability stability|nmod|END_ENTITY	Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast_cancer cells .
22558406	0	Skp2	91,95	p27	99,102	Skp2	p27	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The amelioration of renal_damage in Skp2-deficient mice canceled by p27_Kip1 deficiency in Skp2 - / - p27 - / - mice .
23474082	0	Skp2	0,4	p27	68,71	Skp2	p27	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY inhibits|nsubj|deficiency inhibits|xcomp|independent independent|nmod|accumulation accumulation|compound|END_ENTITY	Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27 -LRB- Kip1 -RRB- accumulation .
24229711	0	Skp2	0,4	p27	24,27	Skp2	p27	6502	3429	Gene	Gene	deletion|compound|START_ENTITY unmasks|nsubj|deletion unmasks|ccomp|safeguard safeguard|nsubj|END_ENTITY	Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors .
24269842	0	Skp2	34,38	p27	0,3	Skp2	p27	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	p27 is regulated independently of Skp2 in the absence of Cdk2 .
25132260	0	Skp2	128,132	p27	114,117	Skp2	p27	6502	3429	Gene	Gene	Kip1|nmod|START_ENTITY Kip1|amod|END_ENTITY	CCN5/WISP -2 promotes growth arrest of triple-negative_breast_cancer cells through accumulation and trafficking of p27 -LRB- Kip1 -RRB- via Skp2 and FOXO3a regulation .
26114183	0	Skp2	12,16	p27	43,46	Skp2	p27	6502	10671	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of Skp2 and its substrate CDKN1B -LRB- p27 -RRB- in colorectal_cancer .
26682002	0	Skp2	107,111	p27	40,43	Skp2	p27	6502	10671	Gene	Gene	Downregulation|compound|START_ENTITY Affecting|nmod|Downregulation Increase|advcl|Affecting Increase|dobj|END_ENTITY	Histone Deacetylase Inhibitors Increase p27 -LRB- Kip1 -RRB- by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation .
26795496	0	Skp2	29,33	p27	0,3	Skp2	p27	6502	10671	Gene	Gene	expression|amod|START_ENTITY ligase|dobj|expression ligase|nsubj|END_ENTITY	p27 and its ubiquitin ligase Skp2 expression in endometrium of IVF patients with repeated hormonal stimulation .
12401804	0	Skp2	115,119	p27Kip1	76,83	Skp2	p27Kip1	6502	1027	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression END_ENTITY|appos|role	PAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1 , a potential role for elevated Skp2 expression .
12813041	0	Skp2	35,39	p27Kip1	100,107	Skp2	p27Kip1	6502	1027	Gene	Gene	amino_acid|nmod|START_ENTITY required|nsubjpass|amino_acid required|nmod|interaction interaction|nmod|END_ENTITY	A negatively charged amino_acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1 .
12904306	0	Skp2	63,67	p27Kip1	24,31	Skp2	p27Kip1	6502	1027	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Estrogens down-regulate p27Kip1 in breast_cancer cells through Skp2 and through nuclear export mediated by the ERK pathway .
15833859	0	Skp2	34,38	p27Kip1	75,82	Skp2	p27Kip1	6502	1027	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|advcl|promote promote|dobj|degradation degradation|amod|END_ENTITY	BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic_myelogenous_leukemia cells .
16537899	0	Skp2	30,34	p27Kip1	45,52	Skp2	p27Kip1	6502	1027	Gene	Gene	associate|nmod|START_ENTITY associate|xcomp|target target|dobj|END_ENTITY	Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome .
16774918	0	Skp2	0,4	p27Kip1	97,104	Skp2	p27Kip1	6502	1027	Gene	Gene	contains|nsubj|START_ENTITY contains|dobj|domain domain|acl:relcl|protects protects|nmod|END_ENTITY	Skp2 contains a novel cyclin_A binding domain that directly protects cyclin_A from inhibition by p27Kip1 .
16951165	0	Skp2	85,89	p27Kip1	0,7	Skp2	p27Kip1	27401(Tax:10090)	12576(Tax:10090)	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|repression repression|amod|END_ENTITY	p27Kip1 repression of ErbB2-induced mammary_tumor growth in transgenic_mice involves Skp2 and Wnt/beta-catenin signaling .
19351827	0	Skp2	140,144	p27Kip1	90,97	Skp2	p27Kip1	6502	1027	Gene	Gene	up-regulation|nmod|START_ENTITY association|nmod|up-regulation induces|nmod|association induces|dobj|activation activation|nmod|down-regulation down-regulation|nmod|END_ENTITY	Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1 , in association with the up-regulation of Skp2 and MiR-222 .
20407011	0	Skp2	16,20	p27Kip1	51,58	Skp2	p27Kip1	6502	1027	Gene	Gene	transcription|amod|START_ENTITY transcription|acl|promote promote|dobj|stabilization stabilization|amod|END_ENTITY	STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells .
18719023	0	Skp2	84,88	p27kip1	16,23	Skp2	p27kip1	6502	1027	Gene	Gene	protein|amod|START_ENTITY down-regulation|nmod|protein stabilizes|nmod|down-regulation stabilizes|dobj|END_ENTITY	EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein .
24441545	0	Skp2	62,66	p27kip1	117,124	Skp2	p27kip1	294790(Tax:10116)	83571(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1 .
18243116	0	Skp2	0,4	p300	54,58	Skp2	p300	6502	2033	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Skp2 suppresses p53-dependent apoptosis by inhibiting p300 .
16530282	0	Sky1p	69,74	Hrb1p	45,50	Sky1p	Hrb1p	855256(Tax:4932)	855728(Tax:4932)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|localization localization|nmod|END_ENTITY	Cellular localization and phosphorylation of Hrb1p is independent of Sky1p .
22825870	0	Sla1	81,85	Scd5	8,12	Sla1	Scd5	852276(Tax:4932)	854507(Tax:4932)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Scd5 , a protein phosphatase-1 targeting protein , in phosphoregulation of Sla1 during endocytosis .
15651983	0	Sla1p	38,43	Lsb5p	0,5	Sla1p	Lsb5p	852276(Tax:4932)	850323(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Lsb5p interacts with actin regulators Sla1p and Las17p , ubiquitin and Arf3p to couple actin dynamics to membrane trafficking processes .
17151356	0	Sla2p	103,108	Arp2/3	40,46	Sla2p	Arp2/3	855478(Tax:4932)	851532(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Negative regulation of yeast Eps15-like Arp2/3 complex activator , Pan1p , by the Hip1R-related protein , Sla2p , during endocytosis .
9140394	0	Sla2p	41,46	HIP1	0,4	Sla2p	HIP1	855478(Tax:4932)	3092	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	HIP1 , a human homologue of S. _ cerevisiae Sla2p , interacts with membrane-associated huntingtin in the brain .
8825655	0	Slap	64,68	Src-like_adapter_protein	38,62	Slap	Src-like adapter protein	20491(Tax:10090)	20491(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosomal localization of the mouse Src-like_adapter_protein -LRB- Slap -RRB- gene and its putative human homolog SLA .
16251521	0	Slc11a1	16,23	Nramp1	25,31	Slc11a1	Nramp1	478909(Tax:9615)	478909(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism of Slc11a1 -LRB- Nramp1 -RRB- gene and canine leishmaniasis in a case-control study .
19116231	0	Slc11a1	13,20	Nramp1	31,37	Slc11a1	Nramp1	18173(Tax:10090)	18173(Tax:10090)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of Slc11a1 -LRB- formerly Nramp1 -RRB- on DSS-induced colitis in mice .
15355847	0	Slc11a2	60,67	DMT1	54,58	Slc11a2	DMT1	25715(Tax:10116)	25715(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of divalent metal transporter DMT1 -LRB- Slc11a2 -RRB- in the spermatogenic epithelium of the developing and adult rat testis .
12161425	0	Slc11a3	57,64	MTP1	51,55	Slc11a3	MTP1	53945(Tax:10090)	53945(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of reticuloendothelial iron transporter MTP1 -LRB- Slc11a3 -RRB- by inflammation .
22194418	0	Slc19a2	107,114	THTR-1	25,31	Slc19a2	THTR-1	116914(Tax:10090)	116914(Tax:10090)	Gene	Gene	contribution|dep|START_ENTITY contribution|nmod|END_ENTITY	Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells : studies utilizing Slc19a2 and Slc19a3 knockout mouse models .
15458920	0	Slc22a1	37,44	Oct1	46,50	Slc22a1	Oct1	20517(Tax:10090)	20517(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of murine Slc22a1 -LRB- Oct1 -RRB- by peroxisome_proliferator_agonist_receptor-alpha and - gamma .
21074513	0	Slc22a12	79,87	Urat1	72,77	Slc22a12	Urat1	365398(Tax:10116)	116085	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Identification and functional characterization of uric_acid transporter Urat1 -LRB- Slc22a12 -RRB- in rats .
16079298	0	Slc22a19	64,72	organic_anion_transporter_5	35,62	Slc22a19	organic anion transporter 5	286961(Tax:10116)	286961(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of rat organic_anion_transporter_5 -LRB- Slc22a19 -RRB- at the apical membrane of renal proximal tubules .
10051314	0	Slc22a2	56,63	organic_cation_transporter_2	21,49	Slc22a2	organic cation transporter 2	20518(Tax:10090)	20518(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the mouse organic_cation_transporter_2 gene , Slc22a2 , from an enhancer-trap transgene integration locus .
15900017	0	Slc22a7	59,66	organic_anion_transporter_2	30,57	Slc22a7	organic anion transporter 2	89776(Tax:10116)	89776(Tax:10116)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Functional involvement of rat organic_anion_transporter_2 -LRB- Slc22a7 -RRB- in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen .
17053783	0	Slc26a6	0,7	CFTR	18,22	Slc26a6	CFTR	171429(Tax:10090)	12638(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3 - secretion : relevance to cystic_fibrosis .
24157454	0	Slc2a2	86,92	solute_carrier_2A2	66,84	Slc2a2	solute carrier 2A2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hepatocyte nuclear factors 1a/4a and forkhead_box_A2 regulate the solute_carrier_2A2 -LRB- Slc2a2 -RRB- gene expression in the liver and kidney of diabetic rats .
23167795	0	Slc2a4	43,49	PPT	28,31	Slc2a4	PPT	6517	6863	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Estrogen_receptor_1 agonist PPT stimulates Slc2a4 gene expression and improves insulin-induced glucose uptake in adipocytes .
20942803	0	Slc30a8	74,81	Pdx-1	58,63	Slc30a8	Pdx-1	239436(Tax:10090)	18609(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	The pancreatic islet b-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer .
23686108	0	Slc39A2	17,24	Zip2	25,29	Slc39A2	Zip2	29986	29986	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Up-regulation of Slc39A2 -LRB- Zip2 -RRB- mRNA in peripheral blood mononuclear cells from patients with pulmonary_tuberculosis .
16804107	0	Slc39a10	84,92	rZip10	76,82	Slc39a10	rZip10	363229(Tax:10116)	100008565(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Molecular cloning and functional characterization of novel zinc transporter rZip10 -LRB- Slc39a10 -RRB- involved in zinc uptake across rat renal brush-border membrane .
17506078	0	Slc39a2	23,30	Zip2	32,36	Slc39a2	Zip2	214922(Tax:10090)	214922(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Targeting of the mouse Slc39a2 -LRB- Zip2 -RRB- gene reveals highly cell-specific patterns of expression , and unique functions in zinc , iron , and calcium homeostasis .
20957146	0	Slc39a4	6,13	Zip4	0,4	Slc39a4	Zip4	55630	55630	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Zip4 -LRB- Slc39a4 -RRB- expression is activated in hepatocellular_carcinomas and functions to repress apoptosis , enhance cell cycle and increase migration .
15705588	0	Slc39a7	15,22	ZIP7	4,8	Slc39a7	ZIP7	7922	7922	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The ZIP7 gene -LRB- Slc39a7 -RRB- encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus .
25088042	0	Slco1d1	106,113	Oatp1d1	97,104	Slco1d1	Oatp1d1	326845(Tax:7955)	326845(Tax:7955)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Interaction of environmental contaminants with zebrafish organic anion transporting polypeptide , Oatp1d1 -LRB- Slco1d1 -RRB- .
17652458	0	Sli15p	8,14	Bir1p	2,7	Sli15p	Bir1p	852453(Tax:4932)	853551(Tax:4932)	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	A Bir1p Sli15p kinetochore passenger complex regulates septin organization during anaphase .
10825204	0	Sli2	0,4	SGK	53,56	Sli2	SGK	171014	6446	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Sli2 -LRB- Ypk1 -RRB- , a homologue of mammalian protein kinase SGK , is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast .
20215404	0	Slik	93,97	Moesin	110,116	Slik	Moesin	37893(Tax:7227)	31816(Tax:7227)	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|activity activity|amod|END_ENTITY	Sip1 , the Drosophila orthologue of EBP50/NHERF1 , functions with the sterile 20 family kinase Slik to regulate Moesin activity .
17565045	0	Slit-2	0,6	Robo-1	7,13	Slit-2	Robo-1	9353	6091	Gene	Gene	START_ENTITY|parataxis|modulates modulates|nsubj|END_ENTITY	Slit-2 / Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells .
18611862	0	Slit-2	0,6	beta-catenin	56,68	Slit-2	beta-catenin	20563(Tax:10090)	12387(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast_cancer cells .
23284807	0	Slit2	0,5	GSK3b	18,23	Slit2	GSK3b	9353	2932	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	Slit2 inactivates GSK3b to signal neurite outgrowth inhibition .
21349947	0	Slit2	88,93	NeuroD1	36,43	Slit2	NeuroD1	9353	4760	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	The neuronal differentiation factor NeuroD1 downregulates the neuronal repellent factor Slit2 expression and promotes cell motility and tumor formation of neuroblastoma .
17968499	0	Slit2	0,5	Robo1	58,63	Slit2	Robo1	9353	6091	Gene	Gene	involvement|amod|START_ENTITY mediated|nsubjpass|involvement mediated|nmod|receptor receptor|amod|END_ENTITY	Slit2 involvement in glioma cell migration is mediated by Robo1 receptor .
22826604	0	Slit2	56,61	Robo1	14,19	Slit2	Robo1	9353	6091	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Activation of Robo1 signaling of breast_cancer cells by Slit2 from stromal fibroblast restrains tumorigenesis via blocking PI3K/Akt/b-catenin pathway .
25894826	0	Slit2	0,5	Robo1	24,29	Slit2	Robo1	20563(Tax:10090)	19876(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Slit2 signaling through Robo1 and Robo2 is required for retinal_neovascularization .
20944010	0	Slit2	0,5	srGAP1	95,101	Slit2	srGAP1	9353	57522	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung_inflammation .
26004511	0	Slitrk5	0,7	TrkB	32,36	Slitrk5	TrkB	26050	4915	Gene	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling .
11533655	0	Slk19	79,84	separase	41,49	Slk19	separase	854370(Tax:4932)	852990(Tax:4932)	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Orchestrating anaphase and mitotic exit : separase cleavage and localization of Slk19 .
24629663	0	Sll0939	0,7	Slr0967	22,29	Sll0939	Slr0967	953493(Tax:1148)	953492(Tax:1148)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Sll0939 is induced by Slr0967 in the cyanobacterium Synechocystis_sp .
22895050	0	Slm1	25,29	Ypk1	76,80	Slm1	Ypk1	854701(Tax:4932)	853733(Tax:4932)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|END_ENTITY	Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. _ cerevisiae .
11097841	0	Sln1	98,102	YHP1	62,66	Sln1	YHP1	854659(Tax:4932)	852062(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive regulation of transcription of homeoprotein-encoding YHP1 by the two-component regulator Sln1 in Saccharomyces_cerevisiae .
22843506	0	Sloan-Kettering_Institute	21,46	Ski	48,51	Sloan-Kettering Institute	Ski	6497	6497	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Differential role of Sloan-Kettering_Institute -LRB- Ski -RRB- protein in Nodal and transforming_growth_factor-beta -LRB- TGF-b -RRB- - induced Smad signaling in prostate_cancer cells .
10521447	0	Slp	110,113	sex-limited_protein	89,108	Slp	sex-limited protein	625018(Tax:10090)	625018(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited_protein -LRB- Slp -RRB- gene .
7877972	0	Slp	60,63	sex-limited_protein	65,84	Slp	sex-limited protein	625018(Tax:10090)	625018(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sexually dimorphic DNA demethylation in the promoter of the Slp -LRB- sex-limited_protein -RRB- gene in mouse liver .
24629663	0	Slr0967	22,29	Sll0939	0,7	Slr0967	Sll0939	953492(Tax:1148)	953493(Tax:1148)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Sll0939 is induced by Slr0967 in the cyanobacterium Synechocystis_sp .
23725563	0	Slr1097	49,56	CRR6	35,39	Slr1097	CRR6	953375(Tax:1148)	819403(Tax:3702)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of a cyanobacterial CRR6 protein , Slr1097 , required for efficient assembly of NDH-1 complexes in Synechocystis_sp .
10958688	0	Sls1p	0,5	Kar2p	47,52	Sls1p	Kar2p	850830(Tax:4932)	853418(Tax:4932)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|END_ENTITY	Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum .
17293484	0	Slt2	101,105	Mpk1	107,111	Slt2	Mpk1	856425(Tax:4932)	856425(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	In the yeast heat_shock response , Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 -LRB- Mpk1 -RRB- mitogen-activated protein kinase required for cell integrity .
7565726	0	Slt2	98,102	Mpk1	92,96	Slt2	Mpk1	856425(Tax:4932)	856425(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 -LRB- Slt2 -RRB- mitogen-activated protein kinase pathway .
9111331	0	Slt2	150,154	Mpk1	144,148	Slt2	Mpk1	856425(Tax:4932)	856425(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Characterization of a serum response factor-like protein in Saccharomyces_cerevisiae , Rlm1 , which has transcriptional activity regulated by the Mpk1 -LRB- Slt2 -RRB- mitogen-activated protein kinase pathway .
22801439	0	Slug	0,4	Cyclin_D1	15,24	Slug	Cyclin D1	6591	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Slug regulates Cyclin_D1 expression by ubiquitin-proteasome pathway in prostate_cancer cells .
12508111	0	Slug	25,29	E-cadherin	40,50	Slug	E-cadherin	20583(Tax:10090)	12550(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions : a comparison with Snail and E47 repressors .
15709186	0	Slug	0,4	E-cadherin	23,33	Slug	E-cadherin	6591	999	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|tumors tumors|amod|END_ENTITY	Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal_squamous_cell_carcinoma .
16943193	0	Slug	89,93	E-cadherin	23,33	Slug	E-cadherin	6591	999	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug .
17018611	0	Slug	106,110	E-cadherin	49,59	Slug	E-cadherin	486940(Tax:9615)	442858(Tax:9615)	Gene	Gene	role|nmod|START_ENTITY reveals|dobj|role reveals|nsubj|profiling profiling|nmod|cells cells|acl|expressing expressing|dobj|repressors repressors|amod|END_ENTITY	Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail , Slug , and E47 factors in epithelial-mesenchymal transition .
18385519	0	Slug	42,46	E-cadherin	170,180	Slug	E-cadherin	6591	999	Gene	Gene	reduces|nsubj|START_ENTITY reduces|advcl|affecting affecting|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression .
19536615	0	Slug	59,63	E-cadherin	29,39	Slug	E-cadherin	6591	999	Gene	Gene	SIP1|dep|START_ENTITY repressors|appos|SIP1 repressors|amod|END_ENTITY	Changes in the expression of E-cadherin repressors , Snail , Slug , SIP1 , and Twist , in the development and progression_of_ovarian_carcinoma : the important role of Snail in ovarian tumorigenesis and progression .
21656704	0	Slug	0,4	E-cadherin	15,25	Slug	E-cadherin	6591	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Slug regulates E-cadherin expression in metastatic adenocarcinoma cells isolated from pleural fluid .
22508482	0	Slug	91,95	E-cadherin	65,75	Slug	E-cadherin	6591	999	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Egr-1 mediates epidermal_growth_factor-induced downregulation of E-cadherin expression via Slug in human ovarian_cancer cells .
24910389	0	Slug	0,4	E-cadherin	15,25	Slug	E-cadherin	6591	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|repression repression|amod|END_ENTITY	Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis .
24464917	0	Slug	51,55	Fhit	0,4	Slug	Fhit	6591	2272	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Fhit regulates EMT targets through an EGFR/Src/ERK / Slug signaling axis in human bronchial cells .
25218351	0	Slug	35,39	HMGA2	0,5	Slug	HMGA2	6591	8091	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon_cancer progression .
21109948	0	Slug	36,40	L1CAM	126,131	Slug	L1CAM	6591	3897	Gene	Gene	Binding|acl|START_ENTITY essential|nsubj|Binding essential|nmod|transforming_growth_factor-b1 transforming_growth_factor-b1|dep|expression expression|compound|END_ENTITY	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
21109948	0	Slug	36,40	L1CAM	48,53	Slug	L1CAM	6591	3897	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
12023284	0	Slug	0,4	MyoD	37,41	Slug	MyoD	20583(Tax:10090)	17927(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Slug is a novel downstream target of MyoD .
21785273	0	Slug	0,4	SNAI2	6,11	Slug	SNAI2	6591	6591	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Slug -LRB- SNAI2 -RRB- expression in oral SCC cells results in altered cell-cell adhesion and increased motility .
26370982	0	Slug	98,102	SOX2	0,4	Slug	SOX2	6591	6657	Gene	Gene	Expression|compound|START_ENTITY Cells|nmod|Expression Transition|nmod|Cells Promotes|nmod|Transition Promotes|nsubj|END_ENTITY	SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-a Signaling .
9838149	0	Slug	75,79	Slugh	81,86	Slug	Slugh	20583(Tax:10090)	20583(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization , expression and chromosomal localization of the mouse Slug -LRB- Slugh -RRB- gene .
10864463	0	Slug	0,4	TGFbeta2	31,39	Slug	TGFbeta2	432368(Tax:9031)	421352(Tax:9031)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Slug is an essential target of TGFbeta2 signaling in the developing chicken heart .
23248240	0	Slug	167,171	Transforming_growth_factor-b1	0,29	Slug	Transforming growth factor-b1	6591	7040	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-b1 induces epithelial-mesenchymal transition and integrin a3b1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug .
16952353	0	Slug	33,37	aryl_hydrocarbon_receptor	64,89	Slug	aryl hydrocarbon receptor	6591	196	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Zinc finger transcription factor Slug is a novel target gene of aryl_hydrocarbon_receptor .
20622260	0	Slug	14,18	c-Myb	35,40	Slug	c-Myb	6591	4602	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin .
20564361	0	Slug	0,4	cyclin_D1	81,90	Slug	cyclin D1	6591	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|proliferation proliferation|nmod|cells cells|nmod|downregulation downregulation|nmod|expression expression|amod|END_ENTITY	Slug inhibits proliferation of human prostate_cancer cells via downregulation of cyclin_D1 expression .
26700673	0	Slug	84,88	miR-497	0,7	Slug	miR-497	6591	574456	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-497 inhibits epithelial mesenchymal transition in breast_carcinoma by targeting Slug .
24008423	0	Slug	0,4	p53	66,69	Slug	p53	20583(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Slug expression in mouse skin and skin_tumors is not regulated by p53 .
25339068	0	Slug	0,4	sox2	67,71	Slug	sox2	6591	6657	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Slug promotes hepatocellular_cancer cell progression by increasing sox2 and nanog expression .
21109948	0	Slug	36,40	transforming_growth_factor-b1	80,109	Slug	transforming growth factor-b1	6591	7040	Gene	Gene	Binding|acl|START_ENTITY essential|nsubj|Binding essential|nmod|END_ENTITY	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
9838149	0	Slugh	81,86	Slug	75,79	Slugh	Slug	20583(Tax:10090)	20583(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization , expression and chromosomal localization of the mouse Slug -LRB- Slugh -RRB- gene .
23139280	0	Slurp1	33,39	Klf4	0,4	Slurp1	Klf4	57277(Tax:10090)	16600(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Klf4 regulates the expression of Slurp1 , which functions as an immunomodulatory peptide in the mouse cornea .
18788627	0	Smac	29,33	Akt	45,48	Smac	Akt	56616	207	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	-LSB- Inhibition of mitochondrial Smac release by Akt in chemoresistant ovarian_cancer cells -RSB- .
18772510	0	Smac	57,61	FGF-2	11,16	Smac	FGF-2	56616	2247	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of FGF-2 on survivin and subcellular location of Smac in human small_cell_lung_cancer cell NCI-H446 -RSB- .
19739098	0	Smac	12,16	NF-kappaB	44,53	Smac	NF-kappaB	56616	4790	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Attenuating Smac mimetic compound 3-induced NF-kappaB activation by luteolin leads to synergistic cytotoxicity in cancer cells .
15280366	0	Smac	61,65	Neuronal_apoptosis-inhibitory_protein	0,37	Smac	Neuronal apoptosis-inhibitory protein	56616	4671	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Neuronal_apoptosis-inhibitory_protein does not interact with Smac and requires ATP to bind caspase-9 .
11717313	1	Smac	153,157	XIAP	169,173	Smac	XIAP	56616	331	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Hid binds Op-IAP in a manner similar to Smac binding of XIAP .
12121969	0	Smac	35,39	XIAP	58,62	Smac	XIAP	56616	331	Gene	Gene	degradation|nmod|START_ENTITY degradation|dep|Smac Smac|compound|END_ENTITY	Proteasome-mediated degradation of Smac during apoptosis : XIAP promotes Smac ubiquitination in vitro .
14512414	0	Smac	149,153	XIAP	112,116	Smac	XIAP	56616	331	Gene	Gene	inhibition|nmod|START_ENTITY Requirement|dep|inhibition Requirement|nmod|relief relief|nmod|inhibitor inhibitor|nmod|protein protein|appos|END_ENTITY	Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein -LRB- XIAP -RRB- - mediated caspase inhibition by Smac .
17291493	0	Smac	118,122	XIAP	8,12	Smac	XIAP	56616	331	Gene	Gene	mimic|nsubj|START_ENTITY molecule|acl:relcl|mimic Role|dep|molecule Role|nmod|END_ENTITY	Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small_cell_lung_cancer cells : a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation .
17686459	0	Smac	19,23	XIAP	64,68	Smac	XIAP	56616	331	Gene	Gene	Phosphorylation|nmod|START_ENTITY attenuates|nsubj|Phosphorylation attenuates|nmod|END_ENTITY	Phosphorylation of Smac by JNK3 attenuates its interaction with XIAP .
17999504	0	Smac	90,94	XIAP	163,167	Smac	XIAP	56616	331	Gene	Gene	mimetic|amod|START_ENTITY mimetic|acl:relcl|targets targets|dobj|BIR2 BIR2|nmod|END_ENTITY	Design , synthesis , and characterization of a potent , nonpeptide , cell-permeable , bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP .
18954041	0	Smac	108,112	XIAP	184,188	Smac	XIAP	56616	331	Gene	Gene	mimetics|amod|START_ENTITY mimetics|nmod|inhibitors inhibitors|nmod|X-linked_inhibitor_of_apoptosis_protein X-linked_inhibitor_of_apoptosis_protein|appos|END_ENTITY	Structure-based design , synthesis , evaluation , and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- .
21354220	0	Smac	16,20	XIAP	67,71	Smac	XIAP	56616	331	Gene	Gene	Dimerization|nmod|START_ENTITY crucial|nsubj|Dimerization crucial|nmod|permeabilization permeabilization|compound|END_ENTITY	Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization .
21364655	0	Smac	13,17	XIAP	0,4	Smac	XIAP	56616	331	Gene	Gene	release|amod|START_ENTITY impairs|dobj|release impairs|nsubj|END_ENTITY	XIAP impairs Smac release from the mitochondria during apoptosis .
21680182	0	Smac	47,51	XIAP	120,124	Smac	XIAP	56616	331	Gene	Gene	Design|nmod|START_ENTITY mimetics|nsubj|Design mimetics|ccomp|END_ENTITY	Design , synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP .
22148838	0	Smac	9,13	XIAP	81,85	Smac	XIAP	56616	331	Gene	Gene	mimetics|nsubj|START_ENTITY mimetics|nmod|core core|nmod|antagonists antagonists|nmod|END_ENTITY	Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents .
22325366	0	Smac	4,8	XIAP	106,110	Smac	XIAP	56616	331	Gene	Gene	HCL|compound|START_ENTITY induces|nsubj|HCL induces|dobj|apoptosis apoptosis|acl|associated associated|advcl|inhibiting inhibiting|dobj|END_ENTITY	The Smac mimetic RMT5265 .2 HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome_C and Smac .
22407164	0	Smac	33,37	XIAP	89,93	Smac	XIAP	56616	331	Gene	Gene	study|nmod|START_ENTITY mimics|nsubj|study mimics|xcomp|targeting targeting|dobj|BIR2 BIR2|nmod|protein protein|compound|END_ENTITY	A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein .
24521431	0	Smac	94,98	XIAP	111,115	Smac	XIAP	56616	331	Gene	Gene	mimetics|amod|START_ENTITY mimetics|nmod|BIR3 BIR3|compound|END_ENTITY	Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells .
14576769	0	Smac	74,78	caspase_9	35,44	Smac	caspase 9	56616	842	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Retinoid-related molecules require caspase_9 for the effective release of Smac and the rapid induction of apoptosis .
15064710	0	Smac	0,4	cytochrome_c	13,25	Smac	cytochrome c	56616	54205	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Smac induces cytochrome_c release and apoptosis independently from Bax/Bcl-x -LRB- L -RRB- in a strictly caspase-3-dependent manner in human carcinoma cells .
18401527	0	Smac	156,160	protein_kinase_C_alpha	89,111	Smac	protein kinase C alpha	56616	5578	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Inhibition of fibroblast_growth_factor_2-induced apoptosis involves survivin expression , protein_kinase_C_alpha activation and subcellular translocation of Smac in human small_cell_lung_cancer cells .
23707512	0	Smad1	10,15	ALK-1	4,9	Smad1	ALK-1	4086	94	Gene	Gene	pathway|nsubj|START_ENTITY END_ENTITY|parataxis|pathway	The ALK-1 / Smad1 pathway in cardiovascular physiopathology .
22299030	0	Smad1	85,90	BMP-9	0,5	Smad1	BMP-9	4086	2658	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|END_ENTITY	BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production .
14635200	0	Smad1	99,104	BMP2	59,63	Smad1	BMP2	395680(Tax:9031)	378779(Tax:9031)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Runx2/Cbfa1 stimulation by retinoic_acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes .
24808138	0	Smad1	0,5	BMP2	38,42	Smad1	BMP2	395680(Tax:9031)	378779(Tax:9031)	Gene	Gene	factor|amod|START_ENTITY integrates|nsubj|factor integrates|dobj|signals signals|compound|END_ENTITY	Smad1 transcription factor integrates BMP2 and Wnt3a signals in migrating cardiac progenitor cells .
11788714	0	Smad1	65,70	Dlx3	52,56	Smad1	Dlx3	17125(Tax:10090)	13393(Tax:10090)	Gene	Gene	transactivates|nmod|START_ENTITY transactivates|dobj|END_ENTITY	Bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- transactivates Dlx3 through Smad1 and Smad4 : alternative mode for Dlx3 induction in mouse keratinocytes .
17676934	0	Smad1	67,72	Smurf1	30,36	Smad1	Smurf1	4086	57154	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1 , Smad5 , and Smad6 -- modeling and analysis .
20803090	0	Smad1	87,92	Transcription_factor_7-like_2	0,29	Smad1	Transcription factor 7-like 2	4086	6934	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- regulates activin_receptor-like_kinase_1 -LRB- ALK1 -RRB- / Smad1 pathway for development of diabetic_nephropathy .
9788633	0	Smad1	50,55	Transforming_growth_factor_beta	0,31	Smad1	Transforming growth factor beta	4086	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Transforming_growth_factor_beta signaling through Smad1 in human breast_cancer cells .
12370310	0	Smad1	116,121	mZnf8	18,23	Smad1	mZnf8	17125(Tax:10090)	243833(Tax:10090)	Gene	Gene	partner|nmod|START_ENTITY Identification|nmod|partner Identification|nmod|END_ENTITY	Identification of mZnf8 , a mouse Kr ppel-like transcriptional repressor , as a novel nuclear interaction partner of Smad1 .
18006160	0	Smad1/4	12,19	bone_morphogenetic_protein-4	42,70	Smad1/4	bone morphogenetic protein-4	4086;4089	652	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|amod|END_ENTITY	Visualizing Smad1/4 signaling response to bone_morphogenetic_protein-4 activation by FRET biosensors .
24614941	0	Smad1/5	44,51	ERK	26,29	Smad1/5	ERK	4086;4090	5594	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence .
18539898	0	Smad1/5/8	34,43	Bmp6	67,71	Smad1/5/8	Bmp6	17125;17129;55994	12161(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6 , Smad7 , Id1 , and Atoh8 in the mouse liver .
23293296	0	Smad2	31,36	Activin_receptor	0,16	Smad2	Activin receptor	31738(Tax:7227)	41772(Tax:7227)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Activin_receptor inhibition by Smad2 regulates Drosophila wing disc patterning through BMP-response elements .
19201832	0	Smad2	24,29	CDK2	0,4	Smad2	CDK2	4087	1017	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone_marrow_myeloma cells .
19309720	0	Smad2	37,42	Connective_tissue_growth_factor	0,31	Smad2	Connective tissue growth factor	29357(Tax:10116)	64032(Tax:10116)	Gene	Gene	amplifier|amod|START_ENTITY amplifier|nsubj|END_ENTITY	Connective_tissue_growth_factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes -- but without modulating bone_morphogenetic_protein_7 signaling .
15067346	0	Smad2	0,5	Erk1/2	15,21	Smad2	Erk1/2	4087	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Smad2 mediates Erk1/2 activation by TGF-beta1 in suspended , but not in adherent , gastric_carcinoma cells .
21437904	0	Smad2	118,123	Ets-2	146,151	Smad2	Ets-2	17126(Tax:10090)	23872(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transforming growth factor-b1 suppression of endotoxin-induced heme oxygenase-1 in macrophages involves activation of Smad2 and downregulation of Ets-2 .
12574210	0	Smad2	40,45	Growth_differentiation_factor-9	0,31	Smad2	Growth differentiation factor-9	4087	2661	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Growth_differentiation_factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells .
24108699	0	Smad2	14,19	Il9	54,57	Smad2	Il9	4087	3578	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Cutting edge : Smad2 and Smad4 regulate TGF-b-mediated Il9 gene expression via EZH2 displacement .
15601644	0	Smad2	63,68	MAN1	0,4	Smad2	MAN1	4087	23592	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MAN1 , an integral protein of the inner nuclear membrane , binds Smad2 and Smad3 and antagonizes transforming_growth_factor-beta signaling .
14612425	0	Smad2	88,93	PAK2	33,37	Smad2	PAK2	4087	5062	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Cell-type-specific activation of PAK2 by transforming_growth_factor_beta independent of Smad2 and Smad3 .
16949833	0	Smad2	61,66	Protein_tyrosine_phosphatase_1B	0,31	Smad2	Protein tyrosine phosphatase 1B	4087	5770	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Protein_tyrosine_phosphatase_1B regulates TGF_beta_1-induced Smad2 activation through PI3 kinase-dependent pathway .
12866583	0	Smad2	50,55	Smad3	57,62	Smad2	Smad3	4087	4088	Gene	Gene	Smad6|dep|START_ENTITY Smad6|dep|END_ENTITY	Mutational analysis of TGF-beta_type_II_receptor , Smad2 , Smad3 , Smad4 , Smad6 and Smad7 genes in colorectal_cancer .
14688282	0	Smad2	18,23	Smad3	26,31	Smad2	Smad3	4087	4088	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Distinct roles of Smad2 - , Smad3 - , and ERK-dependent pathways in transforming_growth_factor-beta1 regulation of pancreatic stellate cellular functions .
16093355	0	Smad2	24,29	Smad3	78,83	Smad2	Smad3	4087	4088	Gene	Gene	ratio|nmod|START_ENTITY influences|nsubj|ratio influences|dobj|function function|nmod|END_ENTITY	The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3 .
21276793	0	Smad2	30,35	Smad3	47,52	Smad2	Smad3	4087	4088	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Comparative effects of TGF-b2 / Smad2 and TGF-b2 / Smad3 signaling pathways on proliferation , migration , and extracellular matrix production in a human lens cell line .
26337383	0	Smad2	59,64	Smad3	48,53	Smad2	Smad3	4087	4088	Gene	Gene	Differentiates|nmod|START_ENTITY Differentiates|dobj|END_ENTITY	Sorting_Nexin_9 Differentiates Ligand-activated Smad3 from Smad2 for Nuclear Import and TGFb Signaling .
9688538	0	Smad2	62,67	Smad3	28,33	Smad2	Smad3	4087	4088	Gene	Gene	activation|nmod|START_ENTITY inhibits|dobj|activation inhibits|nsubj|mutant mutant|nmod|END_ENTITY	A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3 , and has a dominant negative effect on TGF-beta signals .
11456453	0	Smad2	18,23	Smad4	58,63	Smad2	Smad4	17126(Tax:10090)	17128(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY reveals|nsubj|Overexpression reveals|nmod|END_ENTITY	Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis .
12618756	0	Smad2	41,46	Smad4	60,65	Smad2	Smad4	4087	4089	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|lines lines|amod|END_ENTITY	TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines .
12866583	0	Smad2	50,55	Smad4	64,69	Smad2	Smad4	4087	4089	Gene	Gene	Smad6|dep|START_ENTITY Smad6|dep|END_ENTITY	Mutational analysis of TGF-beta_type_II_receptor , Smad2 , Smad3 , Smad4 , Smad6 and Smad7 genes in colorectal_cancer .
18425078	0	Smad2	14,19	Smad4	65,70	Smad2	Smad4	4087	4089	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlates correlates|amod|END_ENTITY	Expression of Smad2 and Smad4 in cervical cancer : absent nuclear Smad4 expression correlates with poor survival .
18595660	0	Smad2	0,5	Smad4	97,102	Smad2	Smad4	4087	4089	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300 .
9346966	0	Smad2	58,63	Smad4	90,95	Smad2	Smad4	4087	4089	Gene	Gene	terminus|nmod|START_ENTITY Ser465|nmod|terminus Phosphorylation|nmod|Ser465 mediates|nsubj|Phosphorylation mediates|nmod|END_ENTITY	Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming_growth_factor-beta signaling .
9812998	0	Smad2	0,5	Smad4	30,35	Smad2	Smad4	29357(Tax:10116)	50554(Tax:10116)	Gene	Gene	overexpression|amod|START_ENTITY enhances|nsubj|overexpression enhances|dobj|expression expression|amod|END_ENTITY	Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic_osteosarcoma ROS17/2 .8 cells and primary rat calvaria cells .
15613484	0	Smad2	72,77	Smad_anchor_for_receptor_activation	95,130	Smad2	Smad anchor for receptor activation	4087	9372	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad_anchor_for_receptor_activation -LRB- SARA -RRB- and Smad2-dependent signaling in human mesangial cells .
11013220	0	Smad2	0,5	Sp1	38,41	Smad2	Sp1	4087	6667	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Smad2 , Smad3 and Smad4 cooperate with Sp1 to induce p15 -LRB- Ink4B -RRB- transcription in response to TGF-beta .
23494890	0	Smad2	15,20	TGF-b	50,55	Smad2	TGF-b	4087	7040	Gene	Gene	activity|amod|START_ENTITY Attenuation|nmod|activity shows|nsubj|Attenuation shows|advcl|END_ENTITY	Attenuation of Smad2 activity shows resistance to TGF-b signalling in mammary adenocarcinoma -LRB- MCF-7 -RRB- cells .
22139024	0	Smad2	53,58	TGF-b1	0,6	Smad2	TGF-b1	4087	7040	Gene	Gene	pathway|amod|START_ENTITY activating|dobj|pathway induces|advcl|activating induces|nsubj|END_ENTITY	TGF-b1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal_carcinomatosis .
24688224	0	Smad2	37,42	TGF-b1	30,36	Smad2	TGF-b1	17126(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY activation|parataxis|signaling activation|nmod|END_ENTITY	Early activation of pulmonary TGF-b1 / Smad2 signaling in mice with acute_pancreatitis-associated acute_lung_injury .
24928277	0	Smad2	94,99	TGF-b1	27,33	Smad2	TGF-b1	4087	7040	Gene	Gene	retention|nmod|START_ENTITY enhancing|dobj|retention accelerates|advcl|enhancing accelerates|nsubj|Induction Induction|nmod|galectin-1 galectin-1|nmod|END_ENTITY	Induction of galectin-1 by TGF-b1 accelerates fibrosis through enhancing nuclear retention of Smad2 .
25351340	0	Smad2	0,5	TGF-b1	23,29	Smad2	TGF-b1	4087	7040	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Smad2 protects against TGF-b1 / Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic_fibrosis .
25891879	0	Smad2	128,133	TGF-b1	121,127	Smad2	TGF-b1	4087	7040	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	AST inhibits H2O2-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-b1 / Smad2 pathway .
14555988	0	Smad2	54,59	TGF-beta	27,35	Smad2	TGF-beta	4087	7040	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Differential regulation of TGF-beta signaling through Smad2 , Smad3 and Smad4 .
17340614	0	Smad2	61,66	TGF-beta	80,88	Smad2	TGF-beta	17126(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	A tale of two proteins : differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling .
10505717	0	Smad2	18,23	TGF-beta1	48,57	Smad2	TGF-beta1	4087	7040	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic_cancer .
16253118	0	Smad2	25,30	TGFbeta1	75,83	Smad2	TGFbeta1	4087	7040	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|responses responses|amod|END_ENTITY	The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells .
16806069	0	Smad2	20,25	TSAd	0,4	Smad2	TSAd	4087	9047	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TSAd interacts with Smad2 and Smad3 .
9346908	0	Smad2	27,32	TbetaRI	0,7	Smad2	TbetaRI	4087	7046	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling .
12853969	0	Smad2	138,143	Transforming_growth_factor-beta1	0,32	Smad2	Transforming growth factor-beta1	4087	7040	Gene	Gene	collaboration|nmod|START_ENTITY signaling|nsubj|collaboration activates|advcl|signaling activates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 activates interleukin-6 expression in prostate_cancer cells through the synergistic collaboration of the Smad2 , p38-NF-kappaB , JNK , and Ras signaling pathways .
12034739	0	Smad2	42,47	Transforming_growth_factor_beta	0,31	Smad2	Transforming growth factor beta	4087	7040	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Transforming_growth_factor_beta activates Smad2 in the absence of receptor endocytosis .
15144593	0	Smad2	92,97	Transforming_growth_factor_beta_1	1,34	Smad2	Transforming growth factor beta 1	17126(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	-LSB- Transforming_growth_factor_beta_1 modulates connective_tissue_growth_factor expression via Smad2 signaling pathway in podocyte in vitro -RSB- .
21599657	0	Smad2	96,101	ZNF580	0,6	Smad2	ZNF580	4087	51157	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ZNF580 , a novel C2H2 zinc-finger transcription factor , interacts with the TGF-b signal molecule Smad2 .
24308972	0	Smad2	51,56	bone_morphogenetic_protein	6,32	Smad2	bone morphogenetic protein	4087	649	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Novel bone_morphogenetic_protein signaling through Smad2 and Smad3 to regulate cancer progression and development .
15144593	0	Smad2	92,97	connective_tissue_growth_factor	45,76	Smad2	connective tissue growth factor	17126(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- Transforming_growth_factor_beta_1 modulates connective_tissue_growth_factor expression via Smad2 signaling pathway in podocyte in vitro -RSB- .
18595660	0	Smad2	0,5	p300	149,153	Smad2	p300	4087	2033	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300 .
16288034	0	Smad2	94,99	phosphatidylinositol_3-kinase	46,75	Smad2	phosphatidylinositol 3-kinase	4087	5293	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|activation activation|nmod|END_ENTITY	Transforming_growth_factor-beta activation of phosphatidylinositol_3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated_kinase-2 .
16788944	0	Smad2	18,23	transforming_growth_factor-beta	27,58	Smad2	transforming growth factor-beta	4087	7040	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Lack of activated Smad2 in transforming_growth_factor-beta signaling is an unfavorable prognostic factor in patients with esophageal_squamous_cell_carcinoma .
20676968	0	Smad2	145,150	transforming_growth_factor-beta1	112,144	Smad2	transforming growth factor-beta1	29357(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	The nonpeptide AVE0991 attenuates myocardial_hypertrophy as induced by angiotensin_II through downregulation of transforming_growth_factor-beta1 / Smad2 expression .
21468608	0	Smad2	0,5	transforming_growth_factor_b1	83,112	Smad2	transforming growth factor b1	4087	7040	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming_growth_factor_b1 .
26252654	0	Smad2/3	100,107	CXCL1	27,32	Smad2/3	CXCL1	4087;4088	2919	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26252654	0	Smad2/3	100,107	CXCL1	27,32	Smad2/3	CXCL1	4087;4088	2919	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
20833252	0	Smad2/3	48,55	Endoglin	0,8	Smad2/3	Endoglin	4087;4088	2022	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Endoglin differentially regulates TGF-b-induced Smad2/3 and Smad1/5 signalling and its expression correlates with extracellular matrix production and cellular differentiation state in human chondrocytes .
26365350	0	Smad2/3	86,93	Follistatin-like_1	0,18	Smad2/3	Follistatin-like 1	4087;4088	11167	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Follistatin-like_1 attenuates differentiation and survival of erythroid cells through Smad2/3 signaling .
19917253	0	Smad2/3	42,49	Nedd4L	17,23	Smad2/3	Nedd4L	17126;17127	83814(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Ubiquitin_ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling .
15372629	0	Smad2/3	57,64	PAI-1	86,91	Smad2/3	PAI-1	17126;17127	18787(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian_cancer cells .
25249655	0	Smad2/3	131,138	TGF-b	116,121	Smad2/3	TGF-b	4087;4088	7040	Gene	Gene	activity|amod|START_ENTITY pathway|dep|activity pathway|amod|END_ENTITY	Comment on `` Controlling long-term signaling : receptor dynamics determine attenuation and refractory behavior of the TGF-b pathway '' - Smad2/3 activity does not predict the dynamics of transcription .
25249656	0	Smad2/3	143,150	TGF-b	128,133	Smad2/3	TGF-b	4087;4088	7040	Gene	Gene	activity|amod|START_ENTITY pathway|dep|activity pathway|amod|END_ENTITY	Response to comment on `` Controlling long-term signaling : receptor dynamics determine attenuation and refractory behavior of the TGF-b pathway '' - Smad2/3 activity does not predict the dynamics of transcription .
26252654	0	Smad2/3	100,107	TGF-b	0,5	Smad2/3	TGF-b	4087;4088	7040	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26252654	0	Smad2/3	100,107	TGF-b	0,5	Smad2/3	TGF-b	4087;4088	7040	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26424816	0	Smad2/3	50,57	TGF-b	41,46	Smad2/3	TGF-b	4087;4088	7040	Gene	Gene	Activity|amod|START_ENTITY END_ENTITY|nmod|Activity	AMPK Inhibits the Stimulatory Effects of TGF-b on Smad2/3 Activity , Cell Migration and Epithelial to Mesenchymal Transition .
26432290	0	Smad2/3	66,73	TGF-b	0,5	Smad2/3	TGF-b	4087;4088	7040	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	TGF-b induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression .
25041068	0	Smad2/3	99,106	TGF-b1	92,98	Smad2/3	TGF-b1	17126;17127	21803(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-b1 / Smad2/3 signalling .
27061332	0	Smad2/3	19,26	TGF-b1	12,18	Smad2/3	TGF-b1	100359137;100346303	100008645(Tax:9986)	Gene	Gene	pathway|amod|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	The role of TGF-b1 / Smad2/3 pathway in platelet-rich plasma in retarding intervertebral_disc_degeneration .
27067480	0	Smad2/3	10,17	TGF-b1	189,195	Smad2/3	TGF-b1	17126;17127	21803(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|dep|Evidence Evidence|nmod|activation activation|nmod|END_ENTITY	Increased Smad2/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic_valve_stenosis : Evidence of systemic activation of platelet-derived TGF-b1 and correlation with cardiac_dysfunction .
12878171	0	Smad3	22,27	ATF-2	0,5	Smad3	ATF-2	395132(Tax:9031)	395727(Tax:9031)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation .
15104092	0	Smad3	28,33	Akt	0,3	Smad3	Akt	4088	207	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis .
19768112	0	Smad3	21,26	BRCA1	0,5	Smad3	BRCA1	4088	672	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses .
20093492	0	Smad3	71,76	Bone_morphogenetic_protein-7	0,28	Smad3	Bone morphogenetic protein-7	4088	655	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Bone_morphogenetic_protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression .
22020340	0	Smad3	0,5	E-cadherin	16,26	Smad3	E-cadherin	4088	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Smad3 regulates E-cadherin via miRNA-200 pathway .
26370086	0	Smad3	121,126	ELL_Protein-associated_Factor_2	0,31	Smad3	ELL Protein-associated Factor 2	4088	55840	Gene	Gene	Inhibits|nmod|START_ENTITY Inhibits|nsubj|END_ENTITY	ELL_Protein-associated_Factor_2 -LRB- EAF2 -RRB- Inhibits Transforming Growth Factor b Signaling through a Direct Interaction with Smad3 .
26393302	0	Smad3	80,85	Growth_Differentiation_Factor-8	0,31	Smad3	Growth Differentiation Factor-8	4088	2660	Gene	Gene	Pathways|nmod|START_ENTITY Pathways|nsubj|Expression Expression|compound|END_ENTITY	Growth_Differentiation_Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells .
11118211	0	Smad3	19,24	HEF1	84,88	Smad3	HEF1	4088	4739	Gene	Gene	ability|nmod|START_ENTITY ability|acl|regulate regulate|dobj|degradation degradation|nmod|END_ENTITY	A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1 .
15144564	0	Smad3	27,32	HEF1	85,89	Smad3	HEF1	4088	4739	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction between Smad3 , APC10 , CDH1 and HEF1 in proteasomal degradation of HEF1 .
19079362	0	Smad3	0,5	Id1	44,47	Smad3	Id1	4088	3397	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Smad3 mediates immediate early induction of Id1 by TGF-beta .
15084595	0	Smad3	0,5	JunB	21,25	Smad3	JunB	4088	3726	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Smad3 interacts with JunB and Cbfa1/Runx2 for transforming_growth_factor-beta1-stimulated collagenase-3 expression in human breast_cancer cells .
26153982	0	Smad3	97,102	MicroRNA-23b	0,12	Smad3	MicroRNA-23b	25631(Tax:10116)	100314002(Tax:10116)	Gene	Gene	Inhibits|nmod|START_ENTITY Inhibits|nsubj|END_ENTITY	MicroRNA-23b Inhibits the Proliferation and Migration of Heat-Denatured Fibroblasts by Targeting Smad3 .
20547485	0	Smad3	0,5	NET1	34,38	Smad3	NET1	4088	10276	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|nmod|END_ENTITY	Smad3 regulates Rho signaling via NET1 in the transforming_growth_factor-beta-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells .
16469949	0	Smad3	26,31	PKCdelta	0,8	Smad3	PKCdelta	25631(Tax:10116)	18753(Tax:10090)	Gene	Gene	necessary|advcl|START_ENTITY necessary|nsubj|END_ENTITY	PKCdelta is necessary for Smad3 expression and transforming growth factor beta-induced fibronectin synthesis in vascular smooth muscle cells .
16484320	0	Smad3	58,63	Parathyroid_hormone	0,19	Smad3	Parathyroid hormone	17127(Tax:10090)	19226(Tax:10090)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Parathyroid_hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells .
16849317	0	Smad3	15,20	RACK1	0,5	Smad3	RACK1	4088	10399	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	RACK1 binds to Smad3 to modulate transforming_growth_factor-beta1-stimulated alpha2 -LRB- I -RRB- _ collagen transcription in renal tubular epithelial cells .
21307346	0	Smad3	46,51	Response_gene_to_complement_32	0,30	Smad3	Response gene to complement 32	4088	28984	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Response_gene_to_complement_32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells .
20732443	0	Smad3	48,53	SLC5A8	18,24	Smad3	SLC5A8	4088	160728	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Activin_A induces SLC5A8 expression through the Smad3 signaling pathway in human colon_cancer RKO cells .
17920684	0	Smad3	77,82	SOCS3	0,5	Smad3	SOCS3	4088	9021	Gene	Gene	signaling|compound|START_ENTITY promotes|nmod|signaling promotes|nsubj|END_ENTITY	SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1 / Smad3 signaling .
15623506	0	Smad3	0,5	SOX9	55,59	Smad3	SOX9	4088	6662	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding_protein / p300 recruitment .
24811173	0	Smad3	61,66	STAT1	173,178	Smad3	STAT1	4088	6772	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Caerulomycin_A enhances transforming_growth_factor-b -LRB- TGF-b -RRB- - Smad3 protein signaling by suppressing interferon-y -LRB- IFN-y -RRB- - signal transducer and activator of transcription 1 -LRB- STAT1 -RRB- protein signaling to expand regulatory T cells -LRB- Tregs -RRB- .
26616859	0	Smad3	33,38	STAT3	0,5	Smad3	STAT3	4088	6774	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	STAT3 selectively interacts with Smad3 to antagonize TGF-b .
23653374	0	Smad3	0,5	Scleraxis	12,21	Smad3	Scleraxis	17127(Tax:10090)	20289(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Smad3 binds Scleraxis and Mohawk and regulates tendon matrix organization .
12866583	0	Smad3	57,62	Smad2	50,55	Smad3	Smad2	4088	4087	Gene	Gene	Smad6|dep|START_ENTITY Smad6|dep|END_ENTITY	Mutational analysis of TGF-beta_type_II_receptor , Smad2 , Smad3 , Smad4 , Smad6 and Smad7 genes in colorectal_cancer .
14688282	0	Smad3	26,31	Smad2	18,23	Smad3	Smad2	4088	4087	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Distinct roles of Smad2 - , Smad3 - , and ERK-dependent pathways in transforming_growth_factor-beta1 regulation of pancreatic stellate cellular functions .
16093355	0	Smad3	78,83	Smad2	24,29	Smad3	Smad2	4088	4087	Gene	Gene	function|nmod|START_ENTITY influences|dobj|function influences|nsubj|ratio ratio|nmod|END_ENTITY	The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3 .
21276793	0	Smad3	47,52	Smad2	30,35	Smad3	Smad2	4088	4087	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Comparative effects of TGF-b2 / Smad2 and TGF-b2 / Smad3 signaling pathways on proliferation , migration , and extracellular matrix production in a human lens cell line .
26337383	0	Smad3	48,53	Smad2	59,64	Smad3	Smad2	4088	4087	Gene	Gene	Differentiates|dobj|START_ENTITY Differentiates|nmod|END_ENTITY	Sorting_Nexin_9 Differentiates Ligand-activated Smad3 from Smad2 for Nuclear Import and TGFb Signaling .
9688538	0	Smad3	28,33	Smad2	62,67	Smad3	Smad2	4088	4087	Gene	Gene	mutant|nmod|START_ENTITY inhibits|nsubj|mutant inhibits|dobj|activation activation|nmod|END_ENTITY	A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3 , and has a dominant negative effect on TGF-beta signals .
25267569	0	Smad3	31,36	Smad3	45,50	Smad3	Smad3	4088	4088	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The prognostic significance of Smad3 , Smad4 , Smad3 phosphoisoform expression in esophageal_squamous_cell_carcinoma .
25267569	0	Smad3	45,50	Smad3	31,36	Smad3	Smad3	4088	4088	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The prognostic significance of Smad3 , Smad4 , Smad3 phosphoisoform expression in esophageal_squamous_cell_carcinoma .
10531318	0	Smad3	0,5	Smad4	87,92	Smad3	Smad4	4088	4089	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transforming_growth_factor-beta transforming_growth_factor-beta|acl|signaling signaling|advcl|competing competing|nmod|END_ENTITY	Smad3 inhibits transforming_growth_factor-beta and activin signaling by competing with Smad4 for FAST-2 binding .
12866583	0	Smad3	57,62	Smad4	64,69	Smad3	Smad4	4088	4089	Gene	Gene	Smad6|dep|START_ENTITY Smad6|dep|END_ENTITY	Mutational analysis of TGF-beta_type_II_receptor , Smad2 , Smad3 , Smad4 , Smad6 and Smad7 genes in colorectal_cancer .
25267569	0	Smad3	31,36	Smad4	38,43	Smad3	Smad4	4088	4089	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The prognostic significance of Smad3 , Smad4 , Smad3 phosphoisoform expression in esophageal_squamous_cell_carcinoma .
25267569	0	Smad3	45,50	Smad4	38,43	Smad3	Smad4	4088	4089	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The prognostic significance of Smad3 , Smad4 , Smad3 phosphoisoform expression in esophageal_squamous_cell_carcinoma .
25531329	0	Smad3	113,118	Smad4	159,164	Smad3	Smad4	4088	4089	Gene	Gene	binding|nmod|START_ENTITY binding|acl|interrupt interrupt|nmod|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
10559222	0	Smad3	56,61	Smad7	14,19	Smad3	Smad7	4088	4092	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|amod|END_ENTITY	Regulation of Smad7 promoter by direct association with Smad3 and Smad4 .
10753944	0	Smad3	0,5	Smad7	64,69	Smad3	Smad7	4088	4092	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|promoter promoter|amod|END_ENTITY	Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta .
12112463	0	Smad3	32,37	Smad7	10,15	Smad3	Smad7	58092(Tax:7955)	326282(Tax:7955)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Zebrafish Smad7 is regulated by Smad3 and BMP signals .
25140399	0	Smad3	83,88	StAR	21,25	Smad3	StAR	4088	6770	Gene	Gene	Pathways|nmod|START_ENTITY Pathways|nsubj|Expression Expression|compound|END_ENTITY	TGF-b1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells .
26393302	0	Smad3	80,85	StAR	42,46	Smad3	StAR	4088	6770	Gene	Gene	Pathways|nmod|START_ENTITY Pathways|nsubj|Expression Expression|compound|END_ENTITY	Growth_Differentiation_Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells .
21305609	0	Smad3	94,99	TGF-b	50,55	Smad3	TGF-b	4088	7040	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Regulation of RANKL-induced osteoclastogenesis by TGF-b through molecular interaction between Smad3 and Traf6 .
22778267	0	Smad3	48,53	TGF-b	41,46	Smad3	TGF-b	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
21354414	0	Smad3	70,75	TGF-b1	63,69	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	contribute|dobj|START_ENTITY contribute|nmod|activation activation|nmod|END_ENTITY	Down-regulation of miR-23b may contribute to activation of the TGF-b1 / Smad3 signalling pathway during the termination stage of liver regeneration .
22161558	0	Smad3	132,137	TGF-b1	125,131	Smad3	TGF-b1	4088	7040	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Hypothesis : human umbilical cord blood-derived stromal cells regulate the Foxp3 expression of regulatory T cells through the TGF-b1 / Smad3 pathway .
23091366	0	Smad3	15,20	TGF-b1	8,14	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY Role|parataxis|signaling Role|nmod|END_ENTITY	Role of TGF-b1 / Smad3 signaling pathway in secretion of type I and III collagen by vascular smooth muscle cells of rats undergoing balloon_injury .
23967091	0	Smad3	73,78	TGF-b1	66,72	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Low-dose paclitaxel ameliorates pulmonary_fibrosis by suppressing TGF-b1 / Smad3 pathway via miR-140 upregulation .
24042439	0	Smad3	96,101	TGF-b1	89,95	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY lung_fibrosis|parataxis|signaling lung_fibrosis|acl|downregulating downregulating|dobj|END_ENTITY	All-transretinoic_acid ameliorates bleomycin-induced lung_fibrosis by downregulating the TGF-b1 / Smad3 signaling pathway in rats .
24291552	0	Smad3	104,109	TGF-b1	32,38	Smad3	TGF-b1	4088	7040	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Inhibition of KCa3 .1 suppresses TGF-b1 induced MCP-1 expression in human proximal tubular cells through Smad3 , p38 and ERK1/2 signaling pathways .
24839113	0	Smad3	117,122	TGF-b1	110,116	Smad3	TGF-b1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Involved|dep|Signaling Involved|nmod|Muscles Muscles|nmod|Unloading Unloading|nmod|Activation Activation|nmod|END_ENTITY	Dystrophin Involved in the Susceptibility of Slow Muscles to Hindlimb Unloading via Concomitant Activation of TGF-b1 / Smad3 Signaling and Ubiquitin-Proteasome Degradation in Mice .
25140399	0	Smad3	83,88	TGF-b1	0,6	Smad3	TGF-b1	4088	7040	Gene	Gene	Pathways|nmod|START_ENTITY Pathways|nsubj|Expression Expression|compound|END_ENTITY	TGF-b1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells .
25406285	0	Smad3	106,111	TGF-b1	99,105	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Fibrosis|parataxis|Pathway Fibrosis|nmod|END_ENTITY	Benzalkonium_Chloride Induces Subconjunctival Fibrosis Through the COX-2-Modulated Activation of a TGF-b1 / Smad3 Signaling Pathway .
25531329	0	Smad3	113,118	TGF-b1	66,72	Smad3	TGF-b1	4088	7040	Gene	Gene	binding|nmod|START_ENTITY inhibits|nmod|binding inhibits|dobj|activity activity|compound|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
25674210	0	Smad3	67,72	TGF-b1	60,66	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY growth|dep|pathway growth|nmod|END_ENTITY	Chitosan inhibits fibroblasts growth in Achilles tendon via TGF-b1 / Smad3 pathway by miR-29b .
26012254	0	Smad3	81,86	TGF-b1	74,80	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY alleviates|parataxis|signaling alleviates|nmod|rats rats|nmod|END_ENTITY	Triptolide alleviates isoprenaline-induced cardiac_remodeling in rats via TGF-b1 / Smad3 and p38_MAPK signaling pathway .
26045780	0	Smad3	145,150	TGF-b1	138,144	Smad3	TGF-b1	4088	7040	Gene	Gene	signaling|nsubj|START_ENTITY inhibitor|parataxis|signaling inhibitor|acl:relcl|reverses reverses|xcomp|epithelial epithelial|xcomp|mesenchymal mesenchymal|dobj|transition transition|nmod|cells cells|acl|blocking blocking|dobj|END_ENTITY	Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-b1 / Smad3 signaling pathway in vitro .
26487518	0	Smad3	89,94	TGF-b1	82,88	Smad3	TGF-b1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Cardiac_Fibrosis|parataxis|Pathway Cardiac_Fibrosis|nmod|END_ENTITY	Notch3 Ameliorates Cardiac_Fibrosis After Myocardial_Infarction by Inhibiting the TGF-b1 / Smad3 Pathway .
26551763	0	Smad3	123,128	TGF-b1	116,122	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	Downregulating|dep|START_ENTITY Downregulating|dep|END_ENTITY	Protective Effect of Zingiber Officinale against CCl4-Induced Liver_Fibrosis Is Mediated through Downregulating the TGF-b1 / Smad3 and NF-x03BA ; B/Ix03BA ; B Pathways .
26604970	0	Smad3	111,116	TGF-b1	104,110	Smad3	TGF-b1	4088	7040	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic_Heart_Failure via TGF-b1 / Smad3 Pathway .
26959841	0	Smad3	117,122	TGF-b1	110,116	Smad3	TGF-b1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY attenuates|parataxis|signaling attenuates|nmod|END_ENTITY	Fenofibrate attenuates diabetic_nephropathy in experimental diabetic rat 's model via suppression of augmented TGF-b1 / Smad3 signaling pathway .
10549282	0	Smad3	40,45	TGF-beta	56,64	Smad3	TGF-beta	4088	7040	Gene	Gene	Ski_oncoprotein|nmod|START_ENTITY Interaction|nmod|Ski_oncoprotein regulates|nsubj|Interaction regulates|dobj|END_ENTITY	Interaction of the Ski_oncoprotein with Smad3 regulates TGF-beta signaling .
11418665	0	Smad3	4,9	TGF-beta	33,41	Smad3	TGF-beta	4088	7040	Gene	Gene	protein|amod|START_ENTITY involved|nsubjpass|protein involved|nmod|inhibition inhibition|amod|END_ENTITY	The Smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression .
11711431	0	Smad3	108,113	TGF-beta	0,8	Smad3	TGF-beta	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3 .
12051713	0	Smad3	14,19	TGF-beta	100,108	Smad3	TGF-beta	4088	7040	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|loop loop|nmod|signaling signaling|compound|END_ENTITY	Regulation of Smad3 expression in bleomycin-induced pulmonary_fibrosis : a negative feedback loop of TGF-beta signaling .
12504095	0	Smad3	18,23	TGF-beta	33,41	Smad3	TGF-beta	4088	7040	Gene	Gene	Reconstitution|nmod|START_ENTITY restores|nsubj|Reconstitution restores|dobj|response response|amod|END_ENTITY	Reconstitution of Smad3 restores TGF-beta response of tissue inhibitor of metalloprotease-1 upregulation in human choriocarcinoma cells .
12814934	0	Smad3	0,5	TGF-beta	60,68	Smad3	TGF-beta	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|dep|player player|nmod|mechanisms mechanisms|amod|dependent dependent|nmod|END_ENTITY	Smad3 : a key player in pathogenetic mechanisms dependent on TGF-beta .
15048128	0	Smad3	72,77	TGF-beta	18,26	Smad3	TGF-beta	4088	7040	Gene	Gene	interaction|nmod|START_ENTITY modulates|nmod|interaction modulates|dobj|signalling signalling|amod|END_ENTITY	PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3 .
15104092	0	Smad3	28,33	TGF-beta	65,73	Smad3	TGF-beta	4088	7040	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|regulate regulate|nmod|apoptosis apoptosis|amod|END_ENTITY	Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis .
15990875	0	Smad3	97,102	TGF-beta	32,40	Smad3	TGF-beta	4088	7040	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3 .
16828225	0	Smad3	107,112	TGF-beta	27,35	Smad3	TGF-beta	4088	7040	Gene	Gene	mutation|nmod|START_ENTITY alterations|dep|mutation alterations|nmod|pathway pathway|amod|END_ENTITY	Genetic alterations of the TGF-beta signaling pathway in colorectal_cancer cell lines : a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation .
16877415	0	Smad3	103,108	TGF-beta	28,36	Smad3	TGF-beta	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY induces|nmod|absence induces|nsubj|expression expression|nmod|END_ENTITY	Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3 .
17934056	0	Smad3	57,62	TGF-beta	24,32	Smad3	TGF-beta	4088	7040	Gene	Gene	evidence|nmod|START_ENTITY Mechanisms|dep|evidence Mechanisms|nmod|action action|nmod|END_ENTITY	Mechanisms of action of TGF-beta in cancer : evidence for Smad3 as a repressor of the hTERT gene .
18794808	0	Smad3	35,40	TGF-beta	98,106	Smad3	TGF-beta	4088	7040	Gene	Gene	ubiquitination|nmod|START_ENTITY regulated|nsubjpass|ubiquitination regulated|nmod|casein_kinase_1_gamma_2 casein_kinase_1_gamma_2|appos|inhibitor inhibitor|nmod|signaling signaling|compound|END_ENTITY	Ligand-dependent ubiquitination of Smad3 is regulated by casein_kinase_1_gamma_2 , an inhibitor of TGF-beta signaling .
19079362	0	Smad3	0,5	TGF-beta	51,59	Smad3	TGF-beta	4088	7040	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Smad3 mediates immediate early induction of Id1 by TGF-beta .
9665135	0	Smad3	66,71	TGF-beta	32,40	Smad3	TGF-beta	4088	7040	Gene	Gene	represses|nmod|START_ENTITY represses|dobj|signalling signalling|amod|END_ENTITY	The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3 .
9796704	0	Smad3	26,31	TGF-beta	87,95	Smad3	TGF-beta	4088	7040	Gene	Gene	apoptosis|nmod|START_ENTITY Induction|nmod|apoptosis Induction|nmod|expression expression|nmod|response response|nmod|END_ENTITY	Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells .
9796704	0	Smad3	55,60	TGF-beta	87,95	Smad3	TGF-beta	4088	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|response response|nmod|END_ENTITY	Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells .
14617750	0	Smad3	33,38	TGF-beta1	23,32	Smad3	TGF-beta1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY protects|nsubj|signaling disruption|parataxis|protects disruption|nmod|END_ENTITY	Targeted disruption of TGF-beta1 / Smad3 signaling protects against renal tubulointerstitial_fibrosis induced by unilateral_ureteral_obstruction .
15240683	0	Smad3	67,72	TGF-beta1	0,9	Smad3	TGF-beta1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY endotoxin|xcomp|signaling endotoxin|nsubj|disrupts disrupts|amod|END_ENTITY	TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways .
15629128	0	Smad3	0,5	TGF-beta1	15,24	Smad3	TGF-beta1	4088	7040	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|compound|END_ENTITY	Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts .
16341574	0	Smad3	0,5	TGF-beta1	98,107	Smad3	TGF-beta1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY decreases|nsubj|inhibitor decreases|dobj|expression expression|nmod|matrix matrix|acl|induced induced|nmod|cells cells|amod|END_ENTITY	Smad3 specific inhibitor , naringenin , decreases the expression of extracellular matrix induced by TGF-beta1 in cultured rat hepatic stellate cells .
16371439	0	Smad3	54,59	TGF-beta1	23,32	Smad3	TGF-beta1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	loop|nmod|START_ENTITY loop|nmod|END_ENTITY	Autocrine loop between TGF-beta1 and IL-1beta through Smad3 - and ERK-dependent pathways in rat pancreatic stellate cells .
17920684	0	Smad3	77,82	TGF-beta1	67,76	Smad3	TGF-beta1	4088	7040	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1 / Smad3 signaling .
20599907	0	Smad3	133,138	TGF-beta1	52,61	Smad3	TGF-beta1	4088	7040	Gene	Gene	interaction|nmod|START_ENTITY regulates|nmod|interaction regulates|dobj|activity activity|amod|END_ENTITY	Glycogen_synthase_kinase-3beta negatively regulates TGF-beta1 and Angiotensin_II-mediated cellular activity through interaction with Smad3 .
21560355	0	Smad3	34,39	TGF-beta1	24,33	Smad3	TGF-beta1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY Effects|dep|pathway Effects|nmod|END_ENTITY	-LSB- Effects of sericine on TGF-beta1 / Smad3 signal pathway of diabetic mephropathy rats kidney -RSB- .
23627095	0	Smad3	54,59	TGF-beta1	44,53	Smad3	TGF-beta1	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY -RSB-|nsubj|pathway Effect|parataxis|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect of Huangqi gegen decoction -LRB- HGD -RRB- on TGF-beta1 / Smad3 pathway in diabetic_cardiomyopathy rats -RSB- .
14636827	0	Smad3	99,104	TGF-beta_1	47,57	Smad3	TGF-beta 1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	Concentration-dependent bifunctional effect of TGF-beta_1 on immunoglobulin production : a role for Smad3 in IgA production in vitro .
15034041	0	Smad3	0,5	TGF-beta_1	23,33	Smad3	TGF-beta 1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Smad3 is essential for TGF-beta_1 to suppress IL-2 production and TCR-induced proliferation , but not IL-2-induced proliferation .
24244446	0	Smad3	93,98	TGFb	127,131	Smad3	TGFb	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY sodium_sulfate-induced|nmod|mice sodium_sulfate-induced|nmod|END_ENTITY	Characterization of dextran sodium_sulfate-induced inflammation and colonic tumorigenesis in Smad3 -LRB- - / - -RRB- mice with dysregulated TGFb .
26639428	0	Smad3	55,60	TGFb	0,4	Smad3	TGFb	4088	7040	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TGFb regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells : implications in intervertebral_disc_degeneration .
22997505	0	Smad3	91,96	TGFb1	0,5	Smad3	TGFb1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Expression|nmod|Signaling Expression|compound|END_ENTITY	TGFb1 Controls PPARy Expression , Transcriptional Potential , and Activity , in Part , through Smad3 Signaling in Murine Lung Fibroblasts .
25326845	0	Smad3	130,135	Transforming_Growth_Factor-Beta1	97,129	Smad3	Transforming Growth Factor-Beta1	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Vitamin_D Prevents the Intestinal Fibrosis Via Induction of Vitamin_D Receptor and Inhibition of Transforming_Growth_Factor-Beta1 / Smad3 Pathway .
22521802	0	Smad3	93,98	Transforming_growth_factor-b	0,28	Smad3	Transforming growth factor-b	25631(Tax:10116)	59086(Tax:10116)	Gene	Gene	vascular|nmod|START_ENTITY vascular|nsubj|increases increases|amod|END_ENTITY	Transforming_growth_factor-b increases vascular smooth muscle cell proliferation through the Smad3 and extracellular_signal-regulated_kinase mitogen-activated protein kinases pathways .
11294908	0	Smad3	58,63	Transforming_growth_factor-beta	0,31	Smad3	Transforming growth factor-beta	4088	7040	Gene	Gene	import|nmod|START_ENTITY induces|dobj|import induces|nsubj|END_ENTITY	Transforming_growth_factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner .
19265200	0	Smad3	32,37	Transforming_growth_factor-beta	0,31	Smad3	Transforming growth factor-beta	4088	7040	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|parataxis|regulates	Transforming_growth_factor-beta / Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function .
14754879	0	Smad3	102,107	Transforming_growth_factor-beta1	0,32	Smad3	Transforming growth factor-beta1	4088	7040	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|inhibition inhibition|amod|END_ENTITY	Transforming_growth_factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3 .
10973958	0	Smad3	86,91	Transforming_growth_factor-beta_1	0,33	Smad3	Transforming growth factor-beta 1	4088	7040	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|inhibition inhibition|amod|END_ENTITY	Transforming_growth_factor-beta_1 inhibition of macrophage activation is mediated via Smad3 .
14729983	0	Smad3	32,37	Transforming_growth_factor_beta	0,31	Smad3	Transforming growth factor beta	4088	7040	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|parataxis|regulates	Transforming_growth_factor_beta / Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter .
22778267	0	Smad3	48,53	Zyxin	0,5	Smad3	Zyxin	17127(Tax:10090)	22793(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
16785237	0	Smad3	93,98	c-Myc	117,122	Smad3	c-Myc	4088	4609	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
19667256	0	Smad3	171,176	connective_tissue_growth_factor	23,54	Smad3	connective tissue growth factor	25631(Tax:10116)	64032(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Angiotensin_II induces connective_tissue_growth_factor and collagen I expression via transforming growth factor-beta-dependent and - independent Smad pathways : the role of Smad3 .
24002653	0	Smad3	0,5	mTOR	34,38	Smad3	mTOR	17127(Tax:10090)	21977(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Smad3 induces atrogin-1 , inhibits mTOR and protein synthesis , and promotes muscle_atrophy in vivo .
22674505	0	Smad3	22,27	matrix_metalloproteinase_13	54,81	Smad3	matrix metalloproteinase 13	17127(Tax:10090)	17386(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix_metalloproteinase_13 expression to maintain articular cartilage and prevent osteoarthritis .
25578496	0	Smad3	63,68	miR-145	0,7	Smad3	miR-145	4088	406937	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-145 inhibits invasion and metastasis by directly targeting Smad3 in nasopharyngeal_cancer .
24496888	0	Smad3	50,55	miR-193b	0,8	Smad3	miR-193b	4088	574455	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-193b promotes cell proliferation by targeting Smad3 in human glioma .
14969849	0	Smad3	32,37	salvianolic_acid_B	10,28	Smad3	salvianolic acid B	4088	9467	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of salvianolic_acid_B on Smad3 expression in hepatic stellate cells .
22778267	0	Smad3	48,53	transforming_growth_factor-b	11,39	Smad3	transforming growth factor-b	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
24811173	0	Smad3	61,66	transforming_growth_factor-b	24,52	Smad3	transforming growth factor-b	4088	7040	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|dep|protein	Caerulomycin_A enhances transforming_growth_factor-b -LRB- TGF-b -RRB- - Smad3 protein signaling by suppressing interferon-y -LRB- IFN-y -RRB- - signal transducer and activator of transcription 1 -LRB- STAT1 -RRB- protein signaling to expand regulatory T cells -LRB- Tregs -RRB- .
10518526	0	Smad3	140,145	transforming_growth_factor-beta	33,64	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	function|nmod|START_ENTITY targeting|dobj|function signaling|advcl|targeting END_ENTITY|acl|signaling	Glucocorticoid_receptor inhibits transforming_growth_factor-beta signaling by directly targeting the transcriptional activation function of Smad3 .
10531318	0	Smad3	0,5	transforming_growth_factor-beta	15,46	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Smad3 inhibits transforming_growth_factor-beta and activin signaling by competing with Smad4 for FAST-2 binding .
11248024	0	Smad3	85,90	transforming_growth_factor-beta	5,36	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	identification|nmod|START_ENTITY coregulator|nsubj|identification coregulator|nmod|END_ENTITY	From transforming_growth_factor-beta signaling to androgen action : identification of Smad3 as an androgen_receptor coregulator in prostate_cancer cells .
11555647	0	Smad3	91,96	transforming_growth_factor-beta	19,50	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	signaling|nmod|START_ENTITY Cross-talk|acl|signaling Cross-talk|nmod|END_ENTITY	Cross-talk between transforming_growth_factor-beta and estrogen_receptor signaling through Smad3 .
12876289	0	Smad3	179,184	transforming_growth_factor-beta	67,98	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	activation|nmod|START_ENTITY suppression|nmod|activation inhibits|nmod|suppression inhibits|dobj|responses responses|nmod|END_ENTITY	Insulin-like_growth_factor-I inhibits transcriptional responses of transforming_growth_factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2 .
14980084	0	Smad3	62,67	transforming_growth_factor-beta	107,138	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	degradation|nmod|START_ENTITY Contribution|nmod|degradation Contribution|nmod|signaling signaling|amod|END_ENTITY	Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming_growth_factor-beta signaling .
15001984	0	Smad3	96,101	transforming_growth_factor-beta	27,58	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|upregulation upregulation|nmod|END_ENTITY	Tenascin-C upregulation by transforming_growth_factor-beta in human dermal fibroblasts involves Smad3 , Sp1 , and Ets1 .
19458083	0	Smad3	112,117	transforming_growth_factor-beta	31,62	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	phosphorylation|compound|START_ENTITY synthase|dobj|phosphorylation synthase|nsubj|control control|nmod|END_ENTITY	A negative feedback control of transforming_growth_factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204 .
20037158	0	Smad3	0,5	transforming_growth_factor-beta	88,119	Smad3	transforming growth factor-beta	4088	7040	Gene	Gene	levels|amod|START_ENTITY modulated|nsubjpass|levels modulated|xcomp|dictate dictate|dobj|responses responses|amod|END_ENTITY	Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming_growth_factor-beta responses .
11438473	0	Smad3	84,89	transforming_growth_factor-beta1	14,46	Smad3	transforming growth factor-beta1	397260(Tax:9823)	397078(Tax:9823)	Gene	Gene	down-regulation|nmod|START_ENTITY involves|dobj|down-regulation involves|nsubj|Alteration Alteration|nmod|response response|amod|END_ENTITY	Alteration of transforming_growth_factor-beta1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosis .
20553715	0	Smad3	89,94	transforming_growth_factor-beta1	26,58	Smad3	transforming growth factor-beta1	4088	7040	Gene	Gene	interacting|nmod|START_ENTITY signaling|advcl|interacting regulates|xcomp|signaling regulates|xcomp|END_ENTITY	DEDD negatively regulates transforming_growth_factor-beta1 signaling by interacting with Smad3 .
15749808	0	Smad3	112,117	tyrosine_hydroxylase	72,92	Smad3	tyrosine hydroxylase	17127(Tax:10090)	21823(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Synergistic activity of activin A and basic_fibroblast_growth_factor on tyrosine_hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways .
19834456	0	Smad4	22,27	4E-BP1	0,6	Smad4	4E-BP1	4089	1978	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation .
22842877	0	Smad4	46,51	BMP-2	40,45	Smad4	BMP-2	4089	650	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Icariin promotes bone formation via the BMP-2 / Smad4 signal transduction pathway in the hFOB_1 .19 human osteoblastic cell line .
14671321	0	Smad4	34,39	DLX-1	13,18	Smad4	DLX-1	4089	1745	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells .
9285566	0	Smad4	41,46	DPC4	35,39	Smad4	DPC4	4089	4089	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Comparative mutational analysis of DPC4 -LRB- Smad4 -RRB- in prostatic and colorectal_carcinomas .
9838102	0	Smad4	40,45	DPC4	47,51	Smad4	DPC4	4089	4089	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Analysis of 5 ' - flanking region of human Smad4 -LRB- DPC4 -RRB- gene .
10531318	0	Smad4	87,92	FAST-2	97,103	Smad4	FAST-2	4089	8928	Gene	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Smad3 inhibits transforming_growth_factor-beta and activin signaling by competing with Smad4 for FAST-2 binding .
21471525	0	Smad4	0,5	Hoxa9	12,17	Smad4	Hoxa9	17128(Tax:10090)	15405(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation .
25514493	0	Smad4	31,36	Pokemon	0,7	Smad4	Pokemon	4089	51341	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pokemon -LRB- FBI-1 -RRB- interacts with Smad4 to repress TGF-b-induced transcriptional responses .
19528490	0	Smad4	35,40	RING_finger_protein11	4,25	Smad4	RING finger protein11	4089	26994	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The RING_finger_protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling .
11456453	0	Smad4	58,63	Smad2	18,23	Smad4	Smad2	17128(Tax:10090)	17126(Tax:10090)	Gene	Gene	reveals|nmod|START_ENTITY reveals|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis .
12618756	0	Smad4	60,65	Smad2	41,46	Smad4	Smad2	4089	4087	Gene	Gene	lines|amod|START_ENTITY localization|nmod|lines localization|nmod|END_ENTITY	TGF-beta-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines .
12866583	0	Smad4	64,69	Smad2	50,55	Smad4	Smad2	4089	4087	Gene	Gene	Smad6|dep|START_ENTITY Smad6|dep|END_ENTITY	Mutational analysis of TGF-beta_type_II_receptor , Smad2 , Smad3 , Smad4 , Smad6 and Smad7 genes in colorectal_cancer .
18425078	0	Smad4	65,70	Smad2	14,19	Smad4	Smad2	4089	4087	Gene	Gene	correlates|amod|START_ENTITY Expression|dep|correlates Expression|nmod|END_ENTITY	Expression of Smad2 and Smad4 in cervical cancer : absent nuclear Smad4 expression correlates with poor survival .
18595660	0	Smad4	97,102	Smad2	0,5	Smad4	Smad2	4089	4087	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300 .
9346966	0	Smad4	90,95	Smad2	58,63	Smad4	Smad2	4089	4087	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|Phosphorylation Phosphorylation|nmod|Ser465 Ser465|nmod|terminus terminus|nmod|END_ENTITY	Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming_growth_factor-beta signaling .
9812998	0	Smad4	30,35	Smad2	0,5	Smad4	Smad2	50554(Tax:10116)	29357(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|overexpression overexpression|amod|END_ENTITY	Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic_osteosarcoma ROS17/2 .8 cells and primary rat calvaria cells .
10531318	0	Smad4	87,92	Smad3	0,5	Smad4	Smad3	4089	4088	Gene	Gene	competing|nmod|START_ENTITY signaling|advcl|competing transforming_growth_factor-beta|acl|signaling inhibits|dobj|transforming_growth_factor-beta inhibits|nsubj|END_ENTITY	Smad3 inhibits transforming_growth_factor-beta and activin signaling by competing with Smad4 for FAST-2 binding .
12866583	0	Smad4	64,69	Smad3	57,62	Smad4	Smad3	4089	4088	Gene	Gene	Smad6|dep|START_ENTITY Smad6|dep|END_ENTITY	Mutational analysis of TGF-beta_type_II_receptor , Smad2 , Smad3 , Smad4 , Smad6 and Smad7 genes in colorectal_cancer .
25267569	0	Smad4	38,43	Smad3	31,36	Smad4	Smad3	4089	4088	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The prognostic significance of Smad3 , Smad4 , Smad3 phosphoisoform expression in esophageal_squamous_cell_carcinoma .
25267569	0	Smad4	38,43	Smad3	45,50	Smad4	Smad3	4089	4088	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The prognostic significance of Smad3 , Smad4 , Smad3 phosphoisoform expression in esophageal_squamous_cell_carcinoma .
25531329	0	Smad4	159,164	Smad3	113,118	Smad4	Smad3	4089	4088	Gene	Gene	interrupt|nmod|START_ENTITY binding|acl|interrupt binding|nmod|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
21273545	0	Smad4	0,5	TGF-b	98,103	Smad4	TGF-b	17128(Tax:10090)	21803(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|processes processes|amod|dependent dependent|nmod|branch branch|nmod|END_ENTITY	Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-b signaling system in the embryonic mouse retina .
21324314	0	Smad4	36,41	TGF-b	18,23	Smad4	TGF-b	4089	7040	Gene	Gene	translocation|amod|START_ENTITY mediated|nmod|translocation mediated|nsubj|role role|nmod|END_ENTITY	Apoptotic role of TGF-b mediated by Smad4 mitochondria translocation and cytochrome_c_oxidase_subunit_II interaction .
21728174	0	Smad4	20,25	TGF-b	0,5	Smad4	TGF-b	17128(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	TGF-b signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE .
22689943	0	Smad4	130,135	TGF-b	12,17	Smad4	TGF-b	780764(Tax:8355)	397778(Tax:8355)	Gene	Gene	localization|nmod|START_ENTITY reflected|nmod|localization reveal|ccomp|reflected reveal|nsubj|Dynamics Dynamics|nmod|signaling signaling|compound|END_ENTITY	Dynamics of TGF-b signaling reveal adaptive and pulsatile_behaviors reflected in the nuclear localization of transcription factor Smad4 .
22821565	0	Smad4	42,47	TGF-b	95,100	Smad4	TGF-b	4089	7040	Gene	Gene	screening|nmod|START_ENTITY identified|nsubj|screening identified|nmod|regulator regulator|nmod|pathway pathway|amod|END_ENTITY	Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-b signalling pathway .
21726607	0	Smad4	85,90	TGF-b1	0,6	Smad4	TGF-b1	4089	7040	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	TGF-b1 inhibits the growth and metastasis of tongue squamous_carcinoma cells through Smad4 .
22028478	0	Smad4	42,47	TGF-b1	86,92	Smad4	TGF-b1	4089	7040	Gene	Gene	down-regulation|nmod|START_ENTITY contributes|nsubj|down-regulation contributes|nmod|sensitivity sensitivity|nmod|stimulation stimulation|compound|END_ENTITY	MicroRNA-130a-mediated down-regulation of Smad4 contributes to reduced sensitivity to TGF-b1 stimulation in granulocytic precursors .
25531329	0	Smad4	159,164	TGF-b1	66,72	Smad4	TGF-b1	4089	7040	Gene	Gene	interrupt|nmod|START_ENTITY binding|acl|interrupt inhibits|nmod|binding inhibits|dobj|activity activity|compound|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
26022109	0	Smad4	118,123	TGF-b1	46,52	Smad4	TGF-b1	4089	7040	Gene	Gene	stability|nmod|START_ENTITY enhancing|dobj|stability signaling|advcl|enhancing END_ENTITY|acl|signaling	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
26022109	0	Smad4	118,123	TGF-b1	46,52	Smad4	TGF-b1	4089	7040	Gene	Gene	stability|nmod|START_ENTITY enhancing|dobj|stability signaling|advcl|enhancing END_ENTITY|acl|signaling	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
11230153	0	Smad4	113,118	TGF-beta	55,63	Smad4	TGF-beta	4089	7040	Gene	Gene	signaling|nmod|START_ENTITY family|acl|signaling family|amod|END_ENTITY	The hepatitis_B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4 : potential mechanism of hepatitis_B virus-induced liver_fibrosis .
11352818	0	Smad4	55,60	TGF-beta	68,76	Smad4	TGF-beta	50554(Tax:10116)	59086(Tax:10116)	Gene	Gene	transfer|nmod|START_ENTITY blocks|nsubj|transfer blocks|dobj|END_ENTITY	Adenovirus-mediated gene transfer of dominant-negative Smad4 blocks TGF-beta signaling in pancreatic acinar cells .
11401854	0	Smad4	0,5	TGF-beta	66,74	Smad4	TGF-beta	50554(Tax:10116)	59086(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells .
12548549	0	Smad4	14,19	TGF-beta	61,69	Smad4	TGF-beta	4089	7040	Gene	Gene	Expression|nmod|START_ENTITY restores|nsubj|Expression restores|dobj|inhibition inhibition|amod|END_ENTITY	Expression of Smad4 in the FaDu cell line partially restores TGF-beta growth inhibition but is not sufficient to regulate fibronectin expression or suppress tumorigenicity .
15110786	0	Smad4	124,129	TGF-beta	26,34	Smad4	TGF-beta	4089	7040	Gene	Gene	expression|amod|START_ENTITY using|nmod|expression cells|acl|using signaling|nmod|cells analysis|acl|signaling analysis|nmod|END_ENTITY	Proteomic analysis of the TGF-beta signaling pathway in pancreatic_carcinoma cells using stable RNA interference to silence Smad4 expression .
15881652	0	Smad4	55,60	TGF-beta	16,24	Smad4	TGF-beta	17128(Tax:10090)	21803(Tax:10090)	Gene	Gene	associating|nmod|START_ENTITY signaling|advcl|associating END_ENTITY|acl|signaling	Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation .
17023741	0	Smad4	23,28	TGF-beta	32,40	Smad4	TGF-beta	4089	7040	Gene	Gene	START_ENTITY|appos|molecule molecule|amod|END_ENTITY	Aberrant expression of Smad4 , a TGF-beta signaling molecule , in oral_squamous_cell_carcinoma .
17132729	0	Smad4	0,5	TGF-beta	127,135	Smad4	TGF-beta	4089	7040	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|absence absence|nmod|signaling signaling|compound|END_ENTITY	Smad4 cooperates with lymphoid_enhancer-binding_factor_1 / T_cell-specific_factor_to_increase_c-myc expression in the absence of TGF-beta signaling .
17301079	0	Smad4	0,5	TGF-beta	64,72	Smad4	TGF-beta	4089	7040	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|down-regulation down-regulation|nmod|E-cadherin E-cadherin|acl|induced induced|nmod|END_ENTITY	Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic_cancer cell line PANC-1 .
19144825	0	Smad4	27,32	TGF-beta	42,50	Smad4	TGF-beta	4089	7040	Gene	Gene	v-ErbA|nmod|START_ENTITY Association|nmod|v-ErbA disrupts|nsubj|Association disrupts|dobj|END_ENTITY	Association of v-ErbA with Smad4 disrupts TGF-beta signaling .
20577838	0	Smad4	10,15	TGF-beta	43,51	Smad4	TGF-beta	4089	7040	Gene	Gene	links|nsubj|START_ENTITY links|xcomp|microRNA-146a microRNA-146a|nmod|pathway pathway|amod|END_ENTITY	Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid_acid induction in acute_promyelocytic_leukemia cell line .
12860278	0	Smad4	46,51	TGF-beta1	22,31	Smad4	TGF-beta1	4089	7040	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Aberrant signaling of TGF-beta1 by the mutant Smad4 in gastric_cancer cells .
19836350	0	Smad4	21,26	Traf2	0,5	Smad4	Traf2	17128(Tax:10090)	22030(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts .
12813045	0	Smad4	86,91	Ubc9	7,11	Smad4	Ubc9	4089	7329	Gene	Gene	accumulation|nmod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	SUMO-1 / Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4 .
27060206	0	Smad4	98,103	aryl_hydrocarbon_receptor	19,44	Smad4	aryl hydrocarbon receptor	4089	196	Gene	Gene	degradation|nmod|START_ENTITY inhibits|nmod|degradation inhibits|nsubj|END_ENTITY	Ligand independent aryl_hydrocarbon_receptor inhibits lung_cancer cell invasion by degradation of Smad4 .
17308096	0	Smad4	0,5	claudin-1	16,25	Smad4	claudin-1	4089	9076	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Smad4 regulates claudin-1 expression in a transforming_growth_factor-beta-independent manner in colon_cancer cells .
22507670	0	Smad4	119,124	miR-146a	0,8	Smad4	miR-146a	50554(Tax:10116)	100314241(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	miR-146a , an IL-1b responsive miRNA , induces vascular_endothelial_growth_factor and chondrocyte apoptosis by targeting Smad4 .
26215566	0	Smad4	86,91	miR-431	0,7	Smad4	miR-431	4089	574038	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4 .
26494556	0	Smad4	74,79	microRNA-31	17,28	Smad4	microRNA-31	4089	407035	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	Tumor suppressor microRNA-31 inhibits gastric_carcinogenesis by targeting Smad4 and SGPP2 .
18595660	0	Smad4	97,102	p300	149,153	Smad4	p300	4089	2033	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300 .
19385047	0	Smad4	103,108	p300	93,97	Smad4	p300	4089	2033	Gene	Gene	switching|nmod|START_ENTITY switching|dobj|preference preference|nmod|END_ENTITY	TNF-alpha suppressed TGF-beta-induced CTGF expression by switching the binding preference of p300 from Smad4 to p65 .
15592526	0	Smad4	0,5	transforming_growth_factor-beta	118,149	Smad4	transforming growth factor-beta	4089	7040	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	Smad4 silencing in pancreatic_cancer cell lines using stable RNA interference and gene expression profiles induced by transforming_growth_factor-beta .
16083599	0	Smad4	15,20	transforming_growth_factor-beta_receptor_II	59,102	Smad4	transforming growth factor-beta receptor II	4089	7048	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	-LSB- Expression of Smad4 and transforming_growth_factor-beta1 , transforming_growth_factor-beta_receptor_II in cholangiocarcinoma tissue and its biological significance -RSB- .
11234879	0	Smad4	10,15	transforming_growth_factor_beta	34,65	Smad4	transforming growth factor beta	4089	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Preserved Smad4 expression in the transforming_growth_factor_beta signaling pathway is a favorable prognostic factor in patients with advanced gastric_cancer .
20079400	0	Smad5	0,5	Akt2	16,20	Smad5	Akt2	59328(Tax:10116)	25233(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Smad5 regulates Akt2 expression and insulin-induced glucose uptake in L6 myotubes .
17133595	0	Smad5	46,51	Jun_activation_domain-binding_protein_1	0,39	Smad5	Jun activation domain-binding protein 1	4090	10987	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Jun_activation_domain-binding_protein_1 binds Smad5 and inhibits bone morphogenetic protein signaling .
17215250	0	Smad6	39,44	Bone_morphogenetic_protein_2	0,28	Smad6	Bone morphogenetic protein 2	4091	650	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Bone_morphogenetic_protein_2 activates Smad6 gene transcription through bone-specific transcription factor Runx2 .
20016939	0	Smad6	42,47	Hoxc8	0,5	Smad6	Hoxc8	17130(Tax:10090)	15426(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Hoxc8 represses BMP-induced expression of Smad6 .
17215250	0	Smad6	39,44	Runx2	107,112	Smad6	Runx2	4091	860	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nmod|END_ENTITY	Bone_morphogenetic_protein_2 activates Smad6 gene transcription through bone-specific transcription factor Runx2 .
24975445	0	Smad6	100,105	Smad7	107,112	Smad6	Smad7	367100(Tax:10116)	81516(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Amlodipine prevents adriamycin-induced toxicity in cultured rat mesangial cells by up-regulation of Smad6 , Smad7 expression .
24096742	0	Smad6	0,5	TGF-b1	29,35	Smad6	TGF-b1	17130(Tax:10090)	21803(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Smad6 inhibits non-canonical TGF-b1 signalling by recruiting the deubiquitinase A20 to TRAF6 .
19561075	0	Smad6	0,5	Tbx6	47,51	Smad6	Tbx6	4091	6911	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation .
16373339	0	Smad6	59,64	bone_morphogenetic_protein	14,40	Smad6	bone morphogenetic protein	4091	649	Gene	Gene	activation|amod|START_ENTITY signaling|nmod|activation END_ENTITY|acl|signaling	OAZ regulates bone_morphogenetic_protein signaling through Smad6 activation .
17493940	0	Smad6	32,37	bone_morphogenetic_protein	41,67	Smad6	bone morphogenetic protein	4091	649	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Selective inhibitory effects of Smad6 on bone_morphogenetic_protein type I receptors .
15579469	0	Smad7	32,37	AP-1	76,80	Smad7	AP-1	4092	3725	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts .
25063542	0	Smad7	0,5	ATM	15,18	Smad7	ATM	17131(Tax:10090)	11920(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair .
19758997	0	Smad7	28,33	BAMBI	6,11	Smad7	BAMBI	4092	25805	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling .
10995749	0	Smad7	0,5	CD40	20,24	Smad7	CD40	17131(Tax:10090)	21939(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta - induced growth inhibition and apoptosis .
15075243	0	Smad7	0,5	Cdc42	70,75	Smad7	Cdc42	4092	998	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Smad7 is required for TGF-beta-induced activation of the small GTPase Cdc42 .
24211420	0	Smad7	14,19	DNMT1	32,37	Smad7	DNMT1	81516(Tax:10116)	84350(Tax:10116)	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver_fibrosis in rats .
24099773	0	Smad7	36,41	Grg4	20,24	Smad7	Grg4	4092	7091	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling .
18163503	0	Smad7	35,40	Interleukin-1beta	0,17	Smad7	Interleukin-1beta	4092	3553	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Interleukin-1beta up-regulation of Smad7 via NF-kappaB activation in human chondrocytes .
24345480	0	Smad7	98,103	MiR-181c	0,8	Smad7	MiR-181c	4092	406957	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	MiR-181c modulates the proliferation , migration , and invasion of neuroblastoma cells by targeting Smad7 .
23435373	0	Smad7	83,88	MicroRNA-25	0,11	Smad7	MicroRNA-25	4092	407014	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	MicroRNA-25 functions as a potential tumor suppressor in colon_cancer by targeting Smad7 .
18163503	0	Smad7	35,40	NF-kappaB	45,54	Smad7	NF-kappaB	4092	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Interleukin-1beta up-regulation of Smad7 via NF-kappaB activation in human chondrocytes .
16259979	0	Smad7	0,5	NFkappaB	72,80	Smad7	NFkappaB	4092	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB .
10559222	0	Smad7	14,19	Smad3	56,61	Smad7	Smad3	4092	4088	Gene	Gene	promoter|amod|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of Smad7 promoter by direct association with Smad3 and Smad4 .
10753944	0	Smad7	64,69	Smad3	0,5	Smad7	Smad3	4092	4088	Gene	Gene	promoter|amod|START_ENTITY activation|nmod|promoter mediate|dobj|activation mediate|nsubj|END_ENTITY	Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor beta .
12112463	0	Smad7	10,15	Smad3	32,37	Smad7	Smad3	326282(Tax:7955)	58092(Tax:7955)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Zebrafish Smad7 is regulated by Smad3 and BMP signals .
24975445	0	Smad7	107,112	Smad6	100,105	Smad7	Smad6	81516(Tax:10116)	367100(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Amlodipine prevents adriamycin-induced toxicity in cultured rat mesangial cells by up-regulation of Smad6 , Smad7 expression .
12151385	0	Smad7	44,49	Smurf1	0,6	Smad7	Smurf1	4092	57154	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane .
12151385	0	Smad7	63,68	Smurf1	0,6	Smad7	Smurf1	4092	57154	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane .
11163210	0	Smad7	0,5	Smurf2	15,21	Smad7	Smurf2	4092	64750	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation .
12039975	0	Smad7	0,5	TGF-Beta	34,42	Smad7	TGF-Beta	81516(Tax:10116)	59086(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular_epithelial_cells by blocking Smad2 activation .
21931165	0	Smad7	32,37	TGF-b	88,93	Smad7	TGF-b	17131(Tax:10090)	21803(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The deubiquitinase CYLD targets Smad7 protein to regulate transforming_growth_factor_b -LRB- TGF-b -RRB- signaling and the development of regulatory T cells .
22286770	0	Smad7	32,37	TGF-b	49,54	Smad7	TGF-b	4092	7040	Gene	Gene	targets|dobj|START_ENTITY activates|ccomp|targets activates|dobj|signaling signaling|compound|END_ENTITY	The miR-106b-25 cluster targets Smad7 , activates TGF-b signaling , and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast_cancer .
22921829	0	Smad7	51,56	TGF-b	86,91	Smad7	TGF-b	4092	7040	Gene	Gene	interactions|nmod|START_ENTITY basis|nmod|interactions WW|nsubj|basis WW|dobj|domains domains|nmod|Pathways Pathways|compound|END_ENTITY	Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-b Pathways .
24369345	0	Smad7	33,38	TGF-b	50,55	Smad7	TGF-b	4092	7040	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|xcomp|inhibit inhibit|dobj|END_ENTITY	Yin_Yang_1 -LRB- YY1 -RRB- synergizes with Smad7 to inhibit TGF-b signaling in the nucleus .
25518932	0	Smad7	73,78	TGF-b	46,51	Smad7	TGF-b	4092	7040	Gene	Gene	Ubiquitination|compound|START_ENTITY EMT|nmod|Ubiquitination Signaling|nmod|EMT END_ENTITY|xcomp|Signaling	Itch E3 Ubiquitin Ligase Positively Regulates TGF-b Signaling to EMT via Smad7 Ubiquitination .
26859364	0	Smad7	0,5	TGF-b	17,22	Smad7	TGF-b	4092	7040	Gene	Gene	interrupts|amod|START_ENTITY END_ENTITY|nsubj|interrupts	Smad7 interrupts TGF-b signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing_enterocolitis .
23154975	0	Smad7	0,5	TGF-b2	39,45	Smad7	TGF-b2	101009976	101009253	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Smad7 inhibits autocrine expression of TGF-b2 in intestinal epithelial cells in baboon_necrotizing_enterocolitis .
10843994	0	Smad7	118,123	TGF-beta	10,18	Smad7	TGF-beta	17131(Tax:10090)	21803(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY requires|nmod|promoter requires|nsubj|induction induction|amod|END_ENTITY	Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1 , Sp1 , and Smad proteins on the mouse Smad7 promoter .
10843994	0	Smad7	36,41	TGF-beta	10,18	Smad7	TGF-beta	17131(Tax:10090)	21803(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY induction|nmod|gene induction|amod|END_ENTITY	Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1 , Sp1 , and Smad proteins on the mouse Smad7 promoter .
10887185	0	Smad7	109,114	TGF-beta	77,85	Smad7	TGF-beta	81516(Tax:10116)	59086(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY Participation|dep|activation Participation|acl|transforming transforming|dobj|beta beta|appos|END_ENTITY	Participation of Smad2 , Smad3 , and Smad4 in transforming growth factor beta -LRB- TGF-beta -RRB- - induced activation of Smad7 .
14657019	0	Smad7	73,78	TGF-beta	18,26	Smad7	TGF-beta	4092	7040	Gene	Gene	degradation|nmod|START_ENTITY signalling|nmod|degradation superfamily|acl|signalling superfamily|amod|END_ENTITY	Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 .
15885643	0	Smad7	51,56	TGF-beta	78,86	Smad7	TGF-beta	4092	7040	Gene	Gene	T-cells|nmod|START_ENTITY Increase|nmod|T-cells Increase|nmod|elevation elevation|nmod|expression expression|amod|END_ENTITY	Increase of activated T-cells and up-regulation of Smad7 without elevation of TGF-beta expression in tonsils from patients with pustulosis_palmaris et plantaris .
16443684	0	Smad7	44,49	TGF-beta	22,30	Smad7	TGF-beta	4092	7040	Gene	Gene	signaling|nmod|START_ENTITY leads|csubj|signaling leads|nmod|disruption disruption|nmod|END_ENTITY	In vivo disruption of TGF-beta signaling by Smad7 leads to premalignant_ductal_lesions in the pancreas .
16601693	0	Smad7	78,83	TGF-beta	30,38	Smad7	TGF-beta	4092	7040	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation signaling|acl:relcl|promotes signaling|compound|END_ENTITY	Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia .
17194892	0	Smad7	71,76	TGF-beta	16,24	Smad7	TGF-beta	4092	7040	Gene	Gene	induction|nmod|START_ENTITY signaling|nmod|induction END_ENTITY|acl|signaling	KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1 .
18189266	0	Smad7	124,129	TGF-beta	64,72	Smad7	TGF-beta	4092	7040	Gene	Gene	repression|nmod|START_ENTITY enhances|nmod|repression enhances|dobj|pathway pathway|amod|END_ENTITY	Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7 .
18992195	0	Smad7	1,6	TGF-beta	76,84	Smad7	TGF-beta	4092	7040	Gene	Gene	blocks|nsubj|START_ENTITY blocks|dobj|transition transition|acl|induced induced|nmod|END_ENTITY	-LSB- Smad7 instead of Smad6 blocks epithelial-mesenchymal transition induced by TGF-beta in human renal proximal tubule epithelial cells -RSB- .
19352540	0	Smad7	36,41	TGF-beta	14,22	Smad7	TGF-beta	4092	7040	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of TGF-beta signaling by Smad7 .
19878580	0	Smad7	61,66	TGF-beta	72,80	Smad7	TGF-beta	4092	7040	Gene	Gene	START_ENTITY|nmod|proteins proteins|amod|END_ENTITY	Liver_fibrosis secondary to bile_duct_injury : correlation of Smad7 with TGF-beta and extracellular matrix proteins .
20405019	0	Smad7	44,49	TGF-beta	22,30	Smad7	TGF-beta	17131(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY alleviates|csubj|signaling alleviates|nmod|disruption disruption|nmod|END_ENTITY	In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic_asthma but aggravates lung_carcinogenesis in mouse .
9335507	0	Smad7	18,23	TGF-beta	59,67	Smad7	TGF-beta	4092	7040	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|signalling signalling|amod|END_ENTITY	Identification of Smad7 , a TGFbeta-inducible antagonist of TGF-beta signalling .
11518734	0	Smad7	9,14	TGF-beta1	24,33	Smad7	TGF-beta1	4092	7040	Gene	Gene	restores|nsubj|START_ENTITY restores|dobj|END_ENTITY	Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory_bowel_disease .
12605052	0	Smad7	0,5	TGF-beta2	42,51	Smad7	TGF-beta2	100338818(Tax:9986)	100009371(Tax:9986)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|effect effect|nmod|END_ENTITY	Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro .
12479057	0	Smad7	15,20	TGF-beta_1	29,39	Smad7	TGF-beta 1	4092	7040	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	-LSB- Regulation of Smad7 gene by TGF-beta_1 in process of malignant transformation -RSB- .
23959527	0	Smad7	0,5	TGFb	16,20	Smad7	TGFb	81516(Tax:10116)	59086(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Smad7 modulates TGFb signaling during cranial suture development to maintain suture patency .
15218362	0	Smad7	70,75	TIEG	63,67	Smad7	TIEG	4092	7071	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Differential gene expression of TGF_beta inducible early gene -LRB- TIEG -RRB- , Smad7 , Smad2 and Bard1 in normal and malignant breast tissue .
26759305	0	Smad7	76,81	UPF1	34,38	Smad7	UPF1	4092	5976	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular_carcinoma .
12118366	0	Smad7	46,51	Yes-associated_protein	0,22	Smad7	Yes-associated protein	4092	22601(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Yes-associated_protein -LRB- YAP65 -RRB- interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling .
16596258	0	Smad7	46,51	Yes-associated_protein	0,22	Smad7	Yes-associated protein	4092	10413	Gene	Gene	expression|amod|START_ENTITY relation|nmod|expression END_ENTITY|nmod|relation	Yes-associated_protein -LRB- YAP65 -RRB- in relation to Smad7 expression in human pancreatic_ductal_adenocarcinoma .
24369345	0	Smad7	33,38	Yin_Yang_1	0,10	Smad7	Yin Yang 1	4092	7528	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Yin_Yang_1 -LRB- YY1 -RRB- synergizes with Smad7 to inhibit TGF-b signaling in the nucleus .
18593713	0	Smad7	0,5	beta-catenin	17,29	Smad7	beta-catenin	4092	1499	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion .
15632190	0	Smad7	119,124	matrix_metalloproteinase-2	77,103	Smad7	matrix metalloproteinase-2	4092	4313	Gene	Gene	expression|amod|START_ENTITY production|nmod|expression production|amod|END_ENTITY	The amyloid-beta peptide suppresses transforming_growth_factor-beta1-induced matrix_metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells .
17438144	0	Smad7	0,5	transforming_growth_factor_beta	18,49	Smad7	transforming growth factor beta	4092	7040	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Smad7 antagonizes transforming_growth_factor_beta signaling in the nucleus by interfering with functional Smad-DNA complex formation .
9449668	0	Smad8	8,13	BMP-4	33,38	Smad8	BMP-4	379659(Tax:8355)	397874(Tax:8355)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning .
26961602	0	Smad_3	16,22	miR-23b	0,7	Smad 3	miR-23b	17127(Tax:10090)	387217(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-23b targets Smad_3 and ameliorates the LPS-inhibited osteogenic differentiation in preosteoblast MC3T3-E1 cells .
11496185	0	Smad_3	96,102	transforming_growth_factor-beta_receptors_I_and_II	27,77	Smad 3	transforming growth factor-beta receptors I and II	4088	7046;7048	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of transforming_growth_factor-beta_receptors_I_and_II and activation of Smad_3 in keloid fibroblasts .
21445336	0	Smad_7	13,19	gastrin	41,48	Smad 7	gastrin	4092	2520	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	IL1B induced Smad_7 negatively regulates gastrin expression .
11918675	0	Smad_anchor_for_receptor_activation	19,54	SARA	56,60	Smad anchor for receptor activation	SARA	9372	9372	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The FYVE domain in Smad_anchor_for_receptor_activation -LRB- SARA -RRB- is sufficient for localization of SARA in early endosomes and regulates TGF-beta/Smad signalling .
22942286	0	Smad_anchor_for_receptor_activation	69,104	SARA	106,110	Smad anchor for receptor activation	SARA	9372	9372	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Phosphatidylinositol_3-kinase and Rab5 GTPase inversely regulate the Smad_anchor_for_receptor_activation -LRB- SARA -RRB- protein independently of transforming_growth_factor-b1 .
15613484	0	Smad_anchor_for_receptor_activation	95,130	Smad2	72,77	Smad anchor for receptor activation	Smad2	9372	4087	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad_anchor_for_receptor_activation -LRB- SARA -RRB- and Smad2-dependent signaling in human mesangial cells .
20515759	0	Smad_anchor_for_receptor_activation	0,35	TGF-beta	46,54	Smad anchor for receptor activation	TGF-beta	9372	7040	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Smad_anchor_for_receptor_activation -LRB- SARA -RRB- in TGF-beta signaling .
22942286	0	Smad_anchor_for_receptor_activation	69,104	transforming_growth_factor-b1	137,166	Smad anchor for receptor activation	transforming growth factor-b1	9372	7040	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Phosphatidylinositol_3-kinase and Rab5 GTPase inversely regulate the Smad_anchor_for_receptor_activation -LRB- SARA -RRB- protein independently of transforming_growth_factor-b1 .
17189523	0	Smad_ubiquitin_regulatory_factor_2	14,48	Smurf2	50,56	Smad ubiquitin regulatory factor 2	Smurf2	717902(Tax:9544)	717902(Tax:9544)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Smad_ubiquitin_regulatory_factor_2 -LRB- Smurf2 -RRB- in rhesus_monkey endometrium and placenta during early pregnancy .
23042144	0	Smad_ubiquitination_regulatory_factor_1	54,93	activating_protein-1	100,120	Smad ubiquitination regulatory factor 1	activating protein-1	75788(Tax:10090)	16476(Tax:10090)	Gene	Gene	START_ENTITY|nmod|manner manner|amod|END_ENTITY	Tumor_necrosis_factor-a enhances the transcription of Smad_ubiquitination_regulatory_factor_1 in an activating_protein-1 - and Runx2-dependent manner .
12547835	0	Smads_2_and_3	0,13	transforming_growth_factor-beta	46,77	Smads 2 and 3	transforming growth factor-beta	4087;4088	7040	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Smads_2_and_3 are differentially activated by transforming_growth_factor-beta -LRB- TGF-beta -RRB- in quiescent and activated hepatic stellate cells .
9593910	0	Small-Eye	62,71	Sey	73,76	Small-Eye	Sey	18508(Tax:10090)	18508(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	The gonadotropin-releasing hormone system does not develop in Small-Eye -LRB- Sey -RRB- mouse phenotype .
26485468	0	Small_Heterodimer_Partner	49,74	Liver_Receptor_Homolog-1	83,107	Small Heterodimer Partner	Liver Receptor Homolog-1	23957(Tax:10090)	26424(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Regulates|dobj|Expression Regulates|nmod|END_ENTITY	Thyroid_Hormone Regulates the mRNA Expression of Small_Heterodimer_Partner through Liver_Receptor_Homolog-1 .
24050553	0	Small_glutamine-rich_tetratricopeptide_repeat-containing_protein	24,88	SGT	90,93	Small glutamine-rich tetratricopeptide repeat-containing protein	SGT	6449	6449	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of Small_glutamine-rich_tetratricopeptide_repeat-containing_protein -LRB- SGT -RRB- correlated with prognosis of Hepatocellular_carcinoma .
24195513	0	Small_glutamine-rich_tetratricopeptide_repeat-containing_protein	24,88	SGT	90,93	Small glutamine-rich tetratricopeptide repeat-containing protein	SGT	6449	6449	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of Small_glutamine-rich_tetratricopeptide_repeat-containing_protein -LRB- SGT -RRB- correlated with prognosis of Hepatocellular_carcinoma .
24718257	0	Small_kinetochore_associated_protein	0,36	pre-mRNA_processing_factor_19	109,138	Small kinetochore associated protein	pre-mRNA processing factor 19	90417	27339	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Small_kinetochore_associated_protein -LRB- SKAP -RRB- promotes UV-induced cell apoptosis through negatively regulating pre-mRNA_processing_factor_19 -LRB- Prp19 -RRB- .
24375477	0	Small_leucine_zipper_protein	0,28	a-actinin-4	111,122	Small leucine zipper protein	a-actinin-4	10488	81	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Small_leucine_zipper_protein -LRB- sLZIP -RRB- negatively regulates skeletal muscle differentiation via interaction with a-actinin-4 .
12144530	0	Small_ubiquitin-related_modifier-1	0,34	glucocorticoid_receptor	64,87	Small ubiquitin-related modifier-1	glucocorticoid receptor	7341	2908	Gene	Gene	START_ENTITY|dep|modification modification|nmod|END_ENTITY	Small_ubiquitin-related_modifier-1 -LRB- SUMO-1 -RRB- modification of the glucocorticoid_receptor .
19482671	0	Smarca5	36,43	Snf2h	45,50	Smarca5	Snf2h	93762(Tax:10090)	93762(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Nuclear localization of ISWI ATPase Smarca5 -LRB- Snf2h -RRB- in mouse .
23184089	0	Smaug	74,79	nanos	51,56	Smaug	nanos	39034(Tax:7227)	42297(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	microRNA-independent recruitment of Argonaute_1 to nanos mRNA through the Smaug RNA-binding protein .
11940662	0	Smcp	110,114	sperm_mitochondrion-associated_cysteine-rich_protein	56,108	Smcp	sperm mitochondrion-associated cysteine-rich protein	17235(Tax:10090)	17235(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Asthenozoospermia in mice with targeted deletion of the sperm_mitochondrion-associated_cysteine-rich_protein -LRB- Smcp -RRB- gene .
19087957	0	Smk1	68,72	Ime2	45,49	Smk1	Ime2	856167(Tax:4932)	853338(Tax:4932)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces_cerevisiae .
11904430	0	Sml1	95,99	Dun1	4,8	Sml1	Dun1	854945(Tax:4932)	851457(Tax:4932)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|kinase kinase|amod|END_ENTITY	The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1 .
24958100	0	Sml1	63,67	Dun1	6,10	Sml1	Dun1	854945(Tax:4932)	851457(Tax:4932)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron_deficiency .
10767334	0	Smn	22,25	Smn	74,77	Smn	Smn	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|role role|nmod|END_ENTITY	Direct interaction of Smn with dp103 , a putative RNA helicase : a role for Smn in transcription regulation ?
10767334	0	Smn	74,77	Smn	22,25	Smn	Smn	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY interaction|dep|role interaction|nmod|END_ENTITY	Direct interaction of Smn with dp103 , a putative RNA helicase : a role for Smn in transcription regulation ?
11773003	0	Smn	128,131	Smn	24,27	Smn	Smn	6606	6606	Gene	Gene	role|nmod|START_ENTITY interaction|dep|role interaction|nmod|END_ENTITY	Specific interaction of Smn , the spinal_muscular_atrophy determining gene product , with hnRNP-R and gry-rbp/hnRNP-Q : a role for Smn in RNA processing in motor axons ?
11773003	0	Smn	24,27	Smn	128,131	Smn	Smn	6606	6606	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|role role|nmod|END_ENTITY	Specific interaction of Smn , the spinal_muscular_atrophy determining gene product , with hnRNP-R and gry-rbp/hnRNP-Q : a role for Smn in RNA processing in motor axons ?
11773003	0	Smn	128,131	hnRNP-R	88,95	Smn	hnRNP-R	6606	10236	Gene	Gene	role|nmod|START_ENTITY interaction|dep|role interaction|nmod|END_ENTITY	Specific interaction of Smn , the spinal_muscular_atrophy determining gene product , with hnRNP-R and gry-rbp/hnRNP-Q : a role for Smn in RNA processing in motor axons ?
11773003	0	Smn	24,27	hnRNP-R	88,95	Smn	hnRNP-R	6606	10236	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of Smn , the spinal_muscular_atrophy determining gene product , with hnRNP-R and gry-rbp/hnRNP-Q : a role for Smn in RNA processing in motor axons ?
12952942	0	Smn	40,43	survival_motor_neuron	17,38	Smn	survival motor neuron	30432(Tax:7955)	30432(Tax:7955)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Knockdown of the survival_motor_neuron -LRB- Smn -RRB- protein in zebrafish causes defects in motor axon outgrowth and pathfinding .
9070939	0	Smn	98,101	survival_motor_neuron	70,91	Smn	survival motor neuron	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	cDNA isolation , expression , and chromosomal localization of the mouse survival_motor_neuron gene -LRB- Smn -RRB- .
16339192	0	Smo	15,18	Ci/Gli	22,28	Smo	Ci/Gli	33196(Tax:7227)	43767(Tax:7227)	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling from Smo to Ci/Gli : conservation and divergence of Hedgehog pathways from Drosophila to vertebrates .
15676023	0	Smooth	0,6	hnRNP	10,15	Smooth	hnRNP	37254(Tax:7227)	33968(Tax:7227)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Smooth , a hnRNP encoding gene , controls axonal navigation in Drosophila .
12890560	0	Smooth_muscle_gamma-actin	0,25	RhoA	49,53	Smooth muscle gamma-actin	RhoA	396084(Tax:9031)	395442(Tax:9031)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Smooth_muscle_gamma-actin promoter regulation by RhoA and serum_response_factor signaling .
26784250	0	Smoothened	73,83	DYRK1B	0,6	Smoothened	DYRK1B	6608	9149	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance .
12874118	0	Smoothened	0,10	Hedgehog	22,30	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	translates|nsubj|START_ENTITY translates|dobj|levels levels|compound|END_ENTITY	Smoothened translates Hedgehog levels into distinct responses .
15592457	0	Smoothened	11,21	Hedgehog	58,66	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	phosphorylation|nsubj|START_ENTITY phosphorylation|xcomp|essential essential|advcl|END_ENTITY	Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction .
15598741	0	Smoothened	29,39	Hedgehog	43,51	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|activation activation|compound|END_ENTITY	Extensive phosphorylation of Smoothened in Hedgehog pathway activation .
15616566	0	Smoothened	32,42	Hedgehog	0,8	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Hedgehog signalling activity of Smoothened requires phosphorylation by protein_kinase_A and casein_kinase_I .
18987629	0	Smoothened	54,64	Hedgehog	68,76	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	downstream|nmod|START_ENTITY downstream|nmod|signalling signalling|compound|END_ENTITY	G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling .
23385085	0	Smoothened	74,84	Hedgehog	40,48	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	suppressing|dobj|START_ENTITY signaling|advcl|suppressing END_ENTITY|acl|signaling	Drosophila miR-960 negatively regulates Hedgehog signaling by suppressing Smoothened , Costal-2 and Fused .
24985345	0	Smoothened	66,76	Hedgehog	0,8	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	phosphorylation|compound|START_ENTITY promote|dobj|phosphorylation induces|xcomp|promote induces|nsubj|END_ENTITY	Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation .
26973699	0	Smoothened	0,10	Hedgehog	37,45	Smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|stimulation stimulation|compound|END_ENTITY	Smoothened regulation in response to Hedgehog stimulation .
16025116	0	Smpd3	67,72	sphingomyelin_phosphodiesterase_3	32,65	Smpd3	sphingomyelin phosphodiesterase 3	58994(Tax:10090)	58994(Tax:10090)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	A deletion in the gene encoding sphingomyelin_phosphodiesterase_3 -LRB- Smpd3 -RRB- results in osteogenesis and dentinogenesis imperfecta in the mouse .
21561986	0	Smt3	11,15	JNK	37,40	Smt3	JNK	33981(Tax:7227)	44801(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus .
10364461	0	Smt3	0,4	SUMO-1	8,14	Smt3	SUMO-1	852122(Tax:4932)	7341	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Smt3 , a SUMO-1 homolog , is conjugated to Cdc3 , a component of septin rings at the mother-bud neck in budding yeast .
10965129	0	Smtn	37,41	smoothelin	53,63	Smtn	smoothelin	29856(Tax:10090)	29856(Tax:10090)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Structure and chromosome location of Smtn , the mouse smoothelin gene .
20441787	0	Smubp-2	62,69	IGHMBP2	53,60	Smubp-2	IGHMBP2	3508	3508	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the promoter region of the human IGHMBP2 -LRB- Smubp-2 -RRB- gene and its response to TPA in HL-60 cells .
27036023	0	Smurf1	0,6	DAB2IP	21,27	Smurf1	DAB2IP	57154	153090	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Smurf1 regulation of DAB2IP controls cell proliferation and migration .
20621832	0	Smurf1	22,28	ING2	58,62	Smurf1	ING2	57154	3622	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation .
25596283	0	Smurf1	46,52	SND1	0,4	Smurf1	SND1	57154	27044	Gene	Gene	Downstream|nmod|START_ENTITY Downstream|compound|END_ENTITY	SND1 Acts Downstream of TGFb1 and Upstream of Smurf1 to Promote Breast_Cancer_Metastasis .
17676934	0	Smurf1	30,36	Smad1	67,72	Smurf1	Smad1	57154	4086	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Molecular interaction between Smurf1 WW2 domain and PPXY motifs of Smad1 , Smad5 , and Smad6 -- modeling and analysis .
12151385	0	Smurf1	0,6	Smad7	44,49	Smurf1	Smad7	57154	4092	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane .
12151385	0	Smurf1	0,6	Smad7	63,68	Smurf1	Smad7	57154	4092	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane .
21454619	0	Smurf1	14,20	Wolfram_syndrome_protein	31,55	Smurf1	Wolfram syndrome protein	75788(Tax:10090)	22393(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	The E3 ligase Smurf1 regulates Wolfram_syndrome_protein stability at the endoplasmic reticulum .
18208356	0	Smurf1	0,6	hPEM-2	24,30	Smurf1	hPEM-2	57154	23229	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Smurf1 directly targets hPEM-2 , a GEF for Cdc42 , via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway .
22070932	0	Smurf2	0,6	IL17RB	17,23	Smurf2	IL17RB	64750	55540	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2 .
27086113	0	Smurf2	31,37	Nedd8	0,5	Smurf2	Nedd8	64750	4738	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation .
27086113	0	Smurf2	31,37	Nedd8	0,5	Smurf2	Nedd8	64750	4738	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation .
21945933	0	Smurf2	20,26	RLIM	0,4	Smurf2	RLIM	64750	51132	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RLIM interacts with Smurf2 and promotes TGF-b induced U2OS cell migration .
11163210	0	Smurf2	15,21	Smad7	0,5	Smurf2	Smad7	64750	4092	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation .
17189523	0	Smurf2	50,56	Smad_ubiquitin_regulatory_factor_2	14,48	Smurf2	Smad ubiquitin regulatory factor 2	717902(Tax:9544)	717902(Tax:9544)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Smad_ubiquitin_regulatory_factor_2 -LRB- Smurf2 -RRB- in rhesus_monkey endometrium and placenta during early pregnancy .
1833625	0	SnRNP	3,8	HnRNP	26,31	SnRNP	HnRNP	57819	3183	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA .
21920357	0	Snai1	28,33	Mmp15	0,5	Snai1	Mmp15	20613(Tax:10090)	17388(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development .
26484184	0	Snai1	0,5	Nanog	16,21	Snai1	Nanog	6615	79923	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Snai1 represses Nanog to promote embryonic stem cell differentiation .
20936121	0	Snail	16,21	Bmi-1	0,5	Snail	Bmi-1	6615	648	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Bmi-1 Regulates Snail Expression and Promotes Metastasis Ability in Head and Neck Squamous Cancer-Derived ALDH1 Positive Cells .
19124656	0	Snail	38,43	CYLD	19,23	Snail	CYLD	6615	1540	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of CYLD expression by Snail promotes tumor progression in malignant_melanoma .
23196056	0	Snail	0,5	Cyr61	15,20	Snail	Cyr61	6615	3491	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|secretion secretion|amod|END_ENTITY	Snail promotes Cyr61 secretion to prime collective cell migration and form invasive tumor nests in squamous_cell_carcinoma .
21237216	0	Snail	31,36	DDX3	12,16	Snail	DDX3	6615	1654	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of DDX3 in regulating Snail .
23791882	0	Snail	83,88	DYRK2	0,5	Snail	DYRK2	6615	8445	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	DYRK2 controls the epithelial-mesenchymal transition in breast_cancer by degrading Snail .
11323412	0	Snail	104,109	E-cadherin	8,18	Snail	E-cadherin	6615	999	Gene	Gene	up-regulation|nmod|START_ENTITY involves|dobj|up-regulation involves|nsubj|Loss Loss|nmod|expression expression|amod|END_ENTITY	Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail .
14673164	0	Snail	0,5	E-cadherin	15,25	Snail	E-cadherin	6615	999	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|repression repression|amod|END_ENTITY	Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone _ deacetylase_1 -LRB- HDAC1 -RRB- / HDAC2 complex .
16328348	0	Snail	39,44	E-cadherin	49,59	Snail	E-cadherin	6615	999	Gene	Gene	localization|nmod|START_ENTITY localization|appos|repressor repressor|amod|END_ENTITY	Expression and nuclear localization of Snail , an E-cadherin repressor , in adenocarcinomas of the upper gastrointestinal tract .
17587810	0	Snail	73,78	E-cadherin	36,46	Snail	E-cadherin	6615	999	Gene	Gene	repressor|dobj|START_ENTITY repressor|nsubj|signals signals|nmod|transcriptional transcriptional|amod|END_ENTITY	Nuclear localization signals of the E-cadherin transcriptional repressor Snail .
18550773	0	Snail	19,24	E-cadherin	60,70	Snail	E-cadherin	6615	999	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|down-regulation down-regulation|nmod|END_ENTITY	Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian_cancer cells through estrogen_receptor_alpha .
18691339	0	Snail	55,60	E-cadherin	19,29	Snail	E-cadherin	6615	999	Gene	Gene	induction|nmod|START_ENTITY repress|nmod|induction repress|dobj|END_ENTITY	Bile_acids repress E-cadherin through the induction of Snail and increase cancer_invasiveness in human hepatobiliary_carcinoma .
19536615	0	Snail	161,166	E-cadherin	29,39	Snail	E-cadherin	6615	999	Gene	Gene	role|nmod|START_ENTITY Changes|dep|role Changes|nmod|expression expression|nmod|repressors repressors|amod|END_ENTITY	Changes in the expression of E-cadherin repressors , Snail , Slug , SIP1 , and Twist , in the development and progression_of_ovarian_carcinoma : the important role of Snail in ovarian tumorigenesis and progression .
19536615	0	Snail	52,57	E-cadherin	29,39	Snail	E-cadherin	6615	999	Gene	Gene	SIP1|compound|START_ENTITY repressors|appos|SIP1 repressors|amod|END_ENTITY	Changes in the expression of E-cadherin repressors , Snail , Slug , SIP1 , and Twist , in the development and progression_of_ovarian_carcinoma : the important role of Snail in ovarian tumorigenesis and progression .
21808237	0	Snail	14,19	E-cadherin	54,64	Snail	E-cadherin	6615	999	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|repressor repressor|amod|END_ENTITY	Expression of Snail and Slug in renal_cell_carcinoma : E-cadherin repressor Snail is associated with cancer_invasion and prognosis .
21808237	0	Snail	75,80	E-cadherin	54,64	Snail	E-cadherin	6615	999	Gene	Gene	associated|nsubjpass|START_ENTITY repressor|acl:relcl|associated repressor|amod|END_ENTITY	Expression of Snail and Slug in renal_cell_carcinoma : E-cadherin repressor Snail is associated with cancer_invasion and prognosis .
22820858	0	Snail	40,45	E-cadherin	18,28	Snail	E-cadherin	6615	999	Gene	Gene	repressors|dobj|START_ENTITY repressors|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the E-cadherin repressors Snail , Slug and Zeb1 in urothelial_carcinoma of the urinary_bladder : relation to stromal fibroblast activation and invasive behaviour of carcinoma cells .
23254865	0	Snail	28,33	E-cadherin	63,73	Snail	E-cadherin	6615	999	Gene	Gene	role|nmod|START_ENTITY role|nmod|changes changes|nmod|END_ENTITY	Possible regulatory role of Snail in NF-kB-mediated changes in E-cadherin in gastric_cancer .
23261431	0	Snail	25,30	E-cadherin	59,69	Snail	E-cadherin	6615	999	Gene	Gene	enhanced|nsubj|START_ENTITY enhanced|dobj|degradation degradation|nmod|END_ENTITY	The transcription factor Snail enhanced the degradation of E-cadherin and desmoglein_2 in oral_squamous_cell_carcinoma cells .
23807483	0	Snail	78,83	E-cadherin	94,104	Snail	E-cadherin	6615	999	Gene	Gene	family|amod|START_ENTITY family|nmod|repressors repressors|amod|END_ENTITY	Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small_cell_lung_cancer .
23856093	0	Snail	68,73	E-cadherin	15,25	Snail	E-cadherin	6615	999	Gene	Gene	transactivation|nmod|START_ENTITY represses|nmod|transactivation represses|dobj|expression expression|amod|END_ENTITY	VAV1 represses E-cadherin expression through the transactivation of Snail and Slug : a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial_ovarian_cancer .
20121949	0	Snail	0,5	EGR-1	22,27	Snail	EGR-1	6615	1958	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b .
26808296	0	Snail	28,33	Erk	80,83	Snail	Erk	6615	5594	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Helicobacter_pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3b in human gastric_cancer cells .
22406531	0	Snail	19,24	G9a	0,3	Snail	G9a	6615	10919	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast_cancer .
17297467	0	Snail	18,23	Gli1	0,4	Snail	Gli1	20613(Tax:10090)	14632(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin .
20637111	0	Snail	41,46	Glycogen_Synthase_Kinase-3beta	0,30	Snail	Glycogen Synthase Kinase-3beta	6615	2932	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Glycogen_Synthase_Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric_cancer cells .
23582741	0	Snail	42,47	Glycogen_synthase_kinase-3_beta	0,31	Snail	Glycogen synthase kinase-3 beta	6615	2932	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase-3_beta regulates Snail and b-catenin expression during Fas-induced epithelial-mesenchymal_transition in gastrointestinal_cancer .
25971970	0	Snail	0,5	HIF1a	28,33	Snail	HIF1a	6615	3091	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	Snail is a Direct Target of HIF1a in Hypoxia-induced Endothelial to Mesenchymal Transition of Human Coronary Endothelial Cells .
16826572	0	Snail	0,5	HNF4alpha	60,69	Snail	HNF4alpha	6615	3172	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|repressing repressing|dobj|expression expression|amod|END_ENTITY	Snail controls differentiation of hepatocytes by repressing HNF4alpha expression .
23288928	0	Snail	78,83	HSP27	14,19	Snail	HSP27	6615	3315	Gene	Gene	degradation|amod|START_ENTITY promoting|dobj|degradation blocks|advcl|promoting blocks|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation .
26348464	0	Snail	82,87	HSP27	15,20	Snail	HSP27	6615	3315	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of HSP27 on Gemcitabine-Resistant Pancreatic_Cancer Cell Line Through Snail .
26348464	0	Snail	82,87	HSP27	15,20	Snail	HSP27	6615	3315	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	The Effects of HSP27 on Gemcitabine-Resistant Pancreatic_Cancer Cell Line Through Snail .
26175937	0	Snail	0,5	Id2	21,24	Snail	Id2	6615	3398	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Snail interacts with Id2 in the regulation of TNF-a-induced cancer cell invasion and migration in OSCC .
21219539	0	Snail	64,69	Matrix_metalloproteinase-9	0,26	Snail	Matrix metalloproteinase-9	6615	4318	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Matrix_metalloproteinase-9 cooperates with transcription factor Snail to induce epithelial-mesenchymal transition .
25003810	0	Snail	0,5	Nanog	16,21	Snail	Nanog	6615	79923	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Snail regulates Nanog status during the epithelial-mesenchymal transition via the Smad1/Akt/GSK3b signaling pathway in non-small-cell_lung_cancer .
24684482	0	Snail	17,22	Notch1	0,6	Snail	Notch1	6615	4851	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Notch1 increases Snail expression under high reactive oxygen species conditions in hepatocellular_carcinoma cells .
24903147	0	Snail	0,5	Ring1B	15,21	Snail	Ring1B	6615	6045	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic_cancer cells .
22903530	0	Snail	91,96	Tumor_necrosis_factor-a	0,23	Snail	Tumor necrosis factor-a	6615	7124	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor-a -LRB- TNF-a -RRB- stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma .
18554584	0	Snail	48,53	Vascular_endothelial_growth_factor-A	0,36	Snail	Vascular endothelial growth factor-A	6615	7422	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor-A stimulates Snail expression in breast_tumor cells : implications for tumor progression .
15366015	0	Snail	10,15	Worniu	0,6	Snail	Worniu	34908(Tax:7227)	34906(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Worniu , a Snail family zinc-finger protein , is required for brain development in Drosophila .
22595290	0	Snail	0,5	adiponectin	46,57	Snail	adiponectin	6615	9370	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Snail , a transcriptional regulator , represses adiponectin expression by directly binding to an E-box motif in the promoter .
17297467	0	Snail	18,23	beta-catenin	71,83	Snail	beta-catenin	20613(Tax:10090)	12387(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|xcomp|promote promote|nmod|END_ENTITY	Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin .
18469861	0	Snail	0,5	beta-catenin	61,73	Snail	beta-catenin	6615	1499	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Snail promotes Wnt target gene expression and interacts with beta-catenin .
22638656	0	Snail	81,86	integrin-linked_kinase	19,41	Snail	integrin-linked kinase	6615	3611	Gene	Gene	expression|nmod|START_ENTITY correlates|nmod|expression correlates|amod|END_ENTITY	Over-expression of integrin-linked_kinase correlates with aberrant expression of Snail , E-cadherin and N-cadherin in oral_squamous_cell_carcinoma : implications in tumor progression and metastasis .
15555546	0	Snail	0,5	p21	16,19	Snail	p21	6615	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Snail regulates p21 -LRB- WAF/CIP1 -RRB- expression in cooperation with E2A_and_Twist .
10853826	0	Snail	0,5	parathyroid_hormone_related_peptide	43,78	Snail	parathyroid hormone related peptide	20613(Tax:10090)	19227(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Snail is an immediate early target gene of parathyroid_hormone_related_peptide signaling in parietal_endoderm formation .
22158034	0	Snail1	20,26	Akt2	0,4	Snail1	Akt2	6615	208	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Akt2 interacts with Snail1 in the E-cadherin promoter .
18519590	0	Snail1	64,70	E-cadherin	35,45	Snail1	E-cadherin	6615	999	Gene	Gene	factor|amod|START_ENTITY required|nmod|factor required|nmod|repression repression|amod|END_ENTITY	Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor .
20801642	0	Snail1	115,121	E-cadherin	79,89	Snail1	E-cadherin	6615	999	Gene	Gene	interaction|nmod|START_ENTITY regulates|nmod|interaction regulates|dobj|transcription transcription|nmod|END_ENTITY	Four and a half LIM protein 2 -LRB- FHL2 -RRB- negatively regulates the transcription of E-cadherin through interaction with Snail1 .
22158034	0	Snail1	20,26	E-cadherin	34,44	Snail1	E-cadherin	6615	999	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Akt2 interacts with Snail1 in the E-cadherin promoter .
24297167	0	Snail1	21,27	E-cadherin	55,65	Snail1	E-cadherin	6615	999	Gene	Gene	role|nmod|START_ENTITY zinc|nsubj|role zinc|nmod|repression repression|amod|END_ENTITY	Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition .
19502595	0	Snail1	23,29	Snail2	0,6	Snail1	Snail2	6615	6591	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Snail2 cooperates with Snail1 in the repression of vitamin_D_receptor in colon_cancer .
17395983	0	Snail1	95,101	colon_cancer	111,123	Snail1	beta-catenin	6615	1499	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin _ D3 is abrogated by Snail1 in human colon_cancer cells .
19502595	0	Snail2	0,6	Snail1	23,29	Snail2	Snail1	6591	6615	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Snail2 cooperates with Snail1 in the repression of vitamin_D_receptor in colon_cancer .
23135794	0	Snap25	80,86	synaptosomal-associated_protein_25	44,78	Snap25	synaptosomal-associated protein 25	25012(Tax:10116)	25012(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental and diurnal expression of the synaptosomal-associated_protein_25 -LRB- Snap25 -RRB- in the rat pineal gland .
23949442	0	Snapin	21,27	LRRK2	0,5	Snapin	LRRK2	295217(Tax:10116)	300160(Tax:10116)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25 .
19482671	0	Snf2h	45,50	Smarca5	36,43	Snf2h	Smarca5	93762(Tax:10090)	93762(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of ISWI ATPase Smarca5 -LRB- Snf2h -RRB- in mouse .
21263029	0	Snf7	16,20	Bro1	0,4	Snf7	Bro1	850712(Tax:4932)	856021(Tax:4932)	Gene	Gene	binding|nmod|START_ENTITY binding|advmod|END_ENTITY	Bro1 binding to Snf7 regulates ESCRT-III membrane scission activity in yeast .
12860994	0	Snf7	86,90	CHMP4b	51,57	Snf7	CHMP4b	850712(Tax:4932)	128866	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The ALG-2-interacting protein Alix associates with CHMP4b , a human homologue of yeast Snf7 that is involved in multivesicular body sorting .
20402793	0	Snf7p	15,20	TIR1	70,74	Snf7p	TIR1	850712(Tax:4932)	856729(Tax:4932)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Involvement of Snf7p and Rim101p in the transcriptional regulation of TIR1 and other anaerobically upregulated genes in Saccharomyces_cerevisiae .
27033517	0	Sng1	0,4	Nce102	21,27	Sng1	Nce102	853111(Tax:4932)	856272(Tax:4932)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status .
12972611	0	Snk	14,17	Plk2	8,12	Snk	Plk2	20620(Tax:10090)	20620(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Plk2 -LRB- Snk -RRB- in mouse development and cell proliferation .
23189151	0	Snm1B	0,5	PSF2	21,25	Snm1B	PSF2	64858	51659	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Snm1B interacts with PSF2 .
9657854	0	Snn	62,65	stannin	53,60	Snn	stannin	20621(Tax:10090)	20621(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal localization and characterization of the stannin -LRB- Snn -RRB- gene .
20457602	0	SnoN	12,16	ADAM12	103,109	SnoN	ADAM12	20482(Tax:10090)	11489(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of SnoN in transforming_growth_factor_beta1-induced expression of metalloprotease-disintegrin ADAM12 .
16109768	0	SnoN	12,16	TGF-beta	70,78	SnoN	TGF-beta	6498	7040	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins .
18537639	0	SnoN	0,4	TGF-beta	8,16	SnoN	TGF-beta	6498	7040	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	SnoN in TGF-beta signaling and cancer biology .
22805162	0	SnoN	0,4	p53	15,18	SnoN	p53	20482(Tax:10090)	22060(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	SnoN activates p53 directly to regulate aging and tumorigenesis .
11696536	0	Socs	14,18	GFI-1B	60,66	Socs	GFI-1B	12700(Tax:10090)	14582(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of Socs gene expression by the proto-oncoprotein GFI-1B : two routes for STAT5 target gene induction by erythropoietin .
15199062	0	Socs-1	53,59	STAT6	0,5	Socs-1	STAT6	8651	6778	Gene	Gene	expression|compound|START_ENTITY modulates|dobj|expression complex|acl:relcl|modulates form|dobj|complex form|nsubj|END_ENTITY	STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes .
19129540	0	Socs-3	112,118	p38	74,77	Socs-3	p38	9021	1432	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3 .
18843197	0	Socs1	69,74	STAT3	104,109	Socs1	STAT3	252971(Tax:10116)	25125(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY downregulation|nmod|gene associated|nsubjpass|downregulation associated|nmod|activation activation|compound|END_ENTITY	Epigenetic downregulation of the suppressor_of_cytokine_signaling_1 -LRB- Socs1 -RRB- gene is associated with the STAT3 activation and development of hepatocellular_carcinoma induced by methyl-deficiency in rats .
18843197	0	Socs1	69,74	suppressor_of_cytokine_signaling_1	33,67	Socs1	suppressor of cytokine signaling 1	252971(Tax:10116)	252971(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic downregulation of the suppressor_of_cytokine_signaling_1 -LRB- Socs1 -RRB- gene is associated with the STAT3 activation and development of hepatocellular_carcinoma induced by methyl-deficiency in rats .
18799889	0	Socs3	87,92	Stat3	10,15	Socs3	Stat3	12702(Tax:10090)	20848(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY analysis|nmod|role Status|dep|analysis Status|nmod|END_ENTITY	Status of Stat3 in an ovalbumin-induced mouse model of asthma : analysis of the role of Socs3 and IL-6 .
23630160	0	Socs3	71,76	Zac1	0,4	Socs3	Zac1	9021	5325	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Zac1 regulates astroglial differentiation of neural stem cells through Socs3 .
23583584	0	Socs36E	0,7	STAT	19,23	Socs36E	STAT	35085(Tax:7227)	42428(Tax:7227)	Gene	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary .
26277564	0	Socs36E	0,7	STAT	15,19	Socs36E	STAT	35085(Tax:7227)	42428(Tax:7227)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Socs36E Limits STAT Signaling via Cullin2 and a SOCS-Box Independent Mechanism in the Drosophila Egg Chamber .
17205581	0	Socs_3	0,6	Stat3	58,63	Socs 3	Stat3	9021	6774	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	Socs_3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis .
3707996	0	Sod	104,107	superoxide_dismutase	82,102	Sod	superoxide dismutase	100274012(Tax:4577)	100274012(Tax:4577)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Effect of the free radical-generating herbicide paraquat on the expression of the superoxide_dismutase -LRB- Sod -RRB- genes in maize .
26185406	0	Sodium-Glucose_Linked_Transporter_2	0,35	SGLT2	37,42	Sodium-Glucose Linked Transporter 2	SGLT2	6524	6524	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Sodium-Glucose_Linked_Transporter_2 -LRB- SGLT2 -RRB- Inhibitors in the Management Of Type-2 Diabetes : A Drug Class Overview .
24972995	0	Sodium-Glucose_linked_transporter_2	0,35	SGLT2	37,42	Sodium-Glucose linked transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Sodium-Glucose_linked_transporter_2 -LRB- SGLT2 -RRB- inhibitors -- fighting diabetes from a new perspective .
21347255	0	Sodium-dependent_vitamin_C_transporter_2	0,40	SVCT2	42,47	Sodium-dependent vitamin C transporter 2	SVCT2	54338(Tax:10090)	54338(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sodium-dependent_vitamin_C_transporter_2 -LRB- SVCT2 -RRB- expression and activity in brain capillary endothelial cells after transient ischemia in mice .
25598831	0	Sodium-glucose_co-transporter_2	0,31	SGLT2	33,38	Sodium-glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Sodium-glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors : a growing class of antidiabetic agents .
16420717	0	Sodium-myo-inositol_co-transporter	0,34	SMIT-1	36,42	Sodium-myo-inositol co-transporter	SMIT-1	6526	6526	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Sodium-myo-inositol_co-transporter -LRB- SMIT-1 -RRB- mRNA is increased in neutrophils of patients with bipolar_1_disorder and down-regulated under treatment with mood stabilizers .
22583331	0	Sodium_glucose_co-transporter_2	0,31	SGLT2	33,38	Sodium glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Sodium_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors : novel antidiabetic agents .
25823168	0	Sodium_glucose_transporter_2	0,28	sglt2	30,35	Sodium glucose transporter 2	sglt2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Sodium_glucose_transporter_2 -LRB- sglt2 -RRB- inhibitors : Current status in clinical practice .
6541432	0	Somatomedin_C	0,13	growth_hormone	26,40	Somatomedin C	growth hormone	3479	2688	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nsubj|response	Somatomedin_C response to growth_hormone in psychosocial_growth_retardation .
10200199	0	Somatostatin	0,12	CA1	21,24	Somatostatin	CA1	24797(Tax:10116)	310218(Tax:10116)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Somatostatin acts in CA1 and CA3 to reduce hippocampal_epileptiform_activity .
1352292	0	Somatostatin	0,12	CREB	89,93	Somatostatin	CREB	6750	1385	Gene	Gene	gene|compound|START_ENTITY activated|nsubj|gene activated|nmod|complex complex|acl|consisting consisting|nmod|END_ENTITY	Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB , Isl-1-like , and alpha-CBF-like transcription factors .
8536603	0	Somatostatin	0,12	GH	39,41	Somatostatin	GH	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|appos|END_ENTITY	Somatostatin increases growth_hormone -LRB- GH -RRB- secretion in a subpopulation of porcine somatotropes : evidence for functional and morphological heterogeneity among porcine GH-producing cells .
21106692	0	Somatostatin	0,12	NHE8	35,39	Somatostatin	NHE8	6750	23315	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Somatostatin stimulates intestinal NHE8 expression via p38 MAPK pathway .
20140708	0	Somatostatin	60,72	SSTR1	99,104	Somatostatin	SSTR1	102170466	102172207	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization and polymorphisms of the caprine Somatostatin -LRB- SST -RRB- and SST Receptor 1 -LRB- SSTR1 -RRB- genes that are linked with growth traits .
7669056	0	Somatostatin	0,12	SSTR2	14,19	Somatostatin	SSTR2	24797(Tax:10116)	54305(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Somatostatin -LRB- SSTR2 -RRB- receptors mediate phospholipase C-independent Ca2 + mobilization in rat AR42J pancreas cells .
15381031	0	Somatostatin	0,12	VEGF	50,54	Somatostatin	VEGF	6750	7422	Gene	Gene	IGF-1|compound|START_ENTITY mediated|nsubj|IGF-1 mediated|dobj|induction induction|nmod|END_ENTITY	Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal_pigment_epithelial cells .
1972871	0	Somatostatin	0,12	bombesin	22,30	Somatostatin	bombesin	6750	2922	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inhibition inhibition|compound|END_ENTITY	Somatostatin mediates bombesin inhibition of chloride secretion by rectal gland .
1350357	0	Somatostatin	0,12	gastrin	27,34	Somatostatin	gastrin	403993(Tax:9615)	100685087	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Somatostatin inhibition of gastrin gene expression : involvement of pertussis toxin-sensitive and - insensitive pathways .
1354190	0	Somatostatin	0,12	gastrin	66,73	Somatostatin	gastrin	494469(Tax:9823)	445524(Tax:9823)	Gene	Gene	link|nsubj|START_ENTITY link|nmod|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Somatostatin is an essential paracrine link in acid inhibition of gastrin secretion .
15935492	0	Somatostatin	0,12	gastrin	46,53	Somatostatin	gastrin	6750	2520	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|amod|END_ENTITY	Somatostatin , misoprostol and galanin inhibit gastrin - and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2 + channels .
1968059	0	Somatostatin	0,12	gastrin	24,31	Somatostatin	gastrin	403993(Tax:9615)	100685087	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|turnover turnover|compound|END_ENTITY	Somatostatin stimulates gastrin mRNA turnover in dog antral mucosa .
1974217	0	Somatostatin	0,12	gastrin	64,71	Somatostatin	gastrin	24797(Tax:10116)	25320(Tax:10116)	Gene	Gene	immunoneutralization|nummod|START_ENTITY increases|nsubj|immunoneutralization increases|dobj|secretion secretion|amod|END_ENTITY	Somatostatin monoclonal antibody immunoneutralization increases gastrin and gastric_acid secretion in urethane-anesthetized rats .
6116596	0	Somatostatin	0,12	gastrin	60,67	Somatostatin	gastrin	100730851	100714563	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Somatostatin is an agonist and noncompetitive antagonist of gastrin in oxyntic cell function .
9227485	0	Somatostatin	0,12	gastrin	22,29	Somatostatin	gastrin	403993(Tax:9615)	100685087	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Somatostatin inhibits gastrin release and acid secretion by activating sst2 in dogs .
1976219	0	Somatostatin	0,12	growth_hormone	55,69	Somatostatin	growth hormone	443006(Tax:9940)	443329(Tax:9940)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|secretion secretion|amod|END_ENTITY	Somatostatin secretion and action in the regulation of growth_hormone secretion .
1977278	0	Somatostatin	0,12	growth_hormone	88,102	Somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	significance|nsubj|START_ENTITY significance|advcl|regulating regulating|dobj|secretion secretion|nmod|END_ENTITY	Somatostatin and its physiological significance in regulating the episodic secretion of growth_hormone in the rat .
20943754	0	Somatostatin	0,12	growth_hormone	126,140	Somatostatin	growth hormone	20604(Tax:10090)	14599(Tax:10090)	Gene	Gene	contribute|nsubj|START_ENTITY contribute|nmod|control control|nmod|axis axis|amod|END_ENTITY	Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic -LRB- fed/fasting -RRB- control of growth_hormone axis in mice .
2862637	0	Somatostatin	0,12	growth_hormone	36,50	Somatostatin	growth hormone	403993(Tax:9615)	403795(Tax:9615)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|ccomp|surges surges|nsubj|effect effect|nmod|END_ENTITY	Somatostatin mediates the effect of growth_hormone surges on splanchnic biogenic amines .
2878057	0	Somatostatin	0,12	growth_hormone	32,46	Somatostatin	growth hormone	443006(Tax:9940)	443329(Tax:9940)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Somatostatin tonically inhibits growth_hormone secretion in domestic fowl .
2900199	0	Somatostatin	0,12	growth_hormone	55,69	Somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Somatostatin as a physiological regulator of pulsatile growth_hormone secretion .
7679974	0	Somatostatin	0,12	growth_hormone	42,56	Somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|transcription transcription|nmod|gene gene|amod|END_ENTITY	Somatostatin reduces transcription of the growth_hormone gene in rats .
7904112	0	Somatostatin	0,12	growth_hormone	71,85	Somatostatin	growth hormone	6750	2688	Gene	Gene	withdrawal|compound|START_ENTITY generator|nsubj|withdrawal generator|nmod|release release|compound|END_ENTITY	Somatostatin withdrawal alone is an ineffective generator of pulsatile growth_hormone release in man .
8536603	0	Somatostatin	0,12	growth_hormone	23,37	Somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|amod|END_ENTITY	Somatostatin increases growth_hormone -LRB- GH -RRB- secretion in a subpopulation of porcine somatotropes : evidence for functional and morphological heterogeneity among porcine GH-producing cells .
7477764	0	Somatostatin	0,12	interleukin-6	46,59	Somatostatin	interleukin-6	6750	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Somatostatin -LRB- SRIF -RRB- stimulates the release of interleukin-6 -LRB- IL-6 -RRB- from human peripheral blood monocytes -LRB- PBM -RRB- in vitro .
9196070	0	Somatostatin	0,12	interleukin_6	22,35	Somatostatin	interleukin 6	24797(Tax:10116)	24498(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|amod|END_ENTITY	Somatostatin inhibits interleukin_6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase .
820704	0	Somatostatin	0,12	parathyroid_hormone	38,57	Somatostatin	parathyroid hormone	6750	5741	Gene	Gene	suppress|nsubj|START_ENTITY suppress|dobj|END_ENTITY	Somatostatin does not suppress plasma parathyroid_hormone .
6150065	0	Somatostatin	0,12	prolactin	22,31	Somatostatin	prolactin	6750	5617	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Somatostatin inhibits prolactin release from the lactotroph primed with oestrogen and cyproterone_acetate in man .
7531454	0	Somatostatin	0,12	substance_P	193,204	Somatostatin	substance P	6750	6863	Gene	Gene	histidine_isoleucine|compound|START_ENTITY histidine_isoleucine|dep|morphometry morphometry|nmod|END_ENTITY	Somatostatin , galanin and peptide histidine_isoleucine in the newborn and adult human trigeminal ganglion and spinal nucleus : immunohistochemistry , neuronal morphometry and colocalization with substance_P .
11304689	0	Somatostatin	0,12	vascular_endothelial_growth_factor	40,74	Somatostatin	vascular endothelial growth factor	6750	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Somatostatin inhibits the production of vascular_endothelial_growth_factor in human glioma cells .
11088001	0	Somatostatin_receptor_1	0,23	SHP-2	172,177	Somatostatin receptor 1	SHP-2	6751	5781	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Somatostatin_receptor_1 -LRB- SSTR1 -RRB- - mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade : role of the phosphotyrosine phosphatase SHP-2 .
16601280	0	Somatostatin_receptor_subtype_5	0,31	SSTR5	33,38	Somatostatin receptor subtype 5	SSTR5	6755	6755	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Somatostatin_receptor_subtype_5 -LRB- SSTR5 -RRB- mRNA expression is related to histopathological features of cell proliferation in insulinomas .
9632136	0	Son-of-sevenless_1	122,140	CDC25	91,96	Son-of-sevenless 1	CDC25	20662(Tax:10090)	12532(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Activation of Ras and its downstream extracellular signal-regulated protein kinases by the CDC25 homology domain of mouse Son-of-sevenless_1 -LRB- mSos1 -RRB- .
22275192	0	Sonic_Hedgehog	19,33	Neogenin	0,8	Sonic Hedgehog	Neogenin	20423(Tax:10090)	18007(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Neogenin regulates Sonic_Hedgehog pathway activity during digit patterning .
22683912	0	Sonic_Hedgehog	39,53	SHH	55,58	Sonic Hedgehog	SHH	6469	6469	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Duplication of 7q36 .3 encompassing the Sonic_Hedgehog -LRB- SHH -RRB- gene is associated with congenital_muscular_hypertrophy .
25750281	0	Sonic_Hedgehog	14,28	SHH	30,33	Sonic Hedgehog	SHH	6469	6469	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Sonic_Hedgehog -LRB- SHH -RRB- in Human Lung_Cancer and the Impact of YangZheng XiaoJi on SHH-mediated Biological Function of Lung_Cancer Cells and Tumor Growth .
22028618	0	Sonic_Hedgehog	26,40	Shh	42,45	Sonic Hedgehog	Shh	20423(Tax:10090)	20423(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Ectopic overexpression of Sonic_Hedgehog -LRB- Shh -RRB- induces stromal expansion and metaplasia in the adult murine pancreas .
11290288	0	Sonic_hedgehog	22,36	CREB	84,88	Sonic hedgehog	CREB	6469	1385	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Vitronectin regulates Sonic_hedgehog activity during cerebellum development through CREB phosphorylation .
12221011	0	Sonic_hedgehog	0,14	Gli1	37,41	Sonic hedgehog	Gli1	6469	2735	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Sonic_hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation .
21539831	0	Sonic_hedgehog	15,29	Hmx4	0,4	Sonic hedgehog	Hmx4	6469	751654(Tax:7955)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Hmx4 regulates Sonic_hedgehog signaling through control of retinoic_acid synthesis during forebrain patterning .
10441331	0	Sonic_hedgehog	18,32	SHH	34,37	Sonic hedgehog	SHH	6469	6469	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the Sonic_hedgehog -LRB- SHH -RRB- gene during early human development and phenotypic expression of new mutations causing holoprosencephaly .
9006067	0	Sonic_hedgehog	15,29	Shh	31,34	Sonic hedgehog	Shh	20423(Tax:10090)	20423(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Sonic_hedgehog -LRB- Shh -RRB- in mouse embryonic lung growth and morphogenesis .
11290288	0	Sonic_hedgehog	22,36	Vitronectin	0,11	Sonic hedgehog	Vitronectin	6469	7448	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Vitronectin regulates Sonic_hedgehog activity during cerebellum development through CREB phosphorylation .
21042410	0	Sonic_hedgehog	18,32	p53	34,37	Sonic hedgehog	p53	30269(Tax:7955)	30590(Tax:7955)	Gene	Gene	absence|nmod|START_ENTITY induces|nmod|absence induces|nsubj|END_ENTITY	In the absence of Sonic_hedgehog , p53 induces apoptosis and inhibits retinal cell proliferation , cell-cycle exit and differentiation in zebrafish .
21385844	0	SorLA	0,5	lipoprotein_lipase	32,50	SorLA	lipoprotein lipase	6653	4023	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	SorLA regulates the activity of lipoprotein_lipase by intracellular trafficking .
26177583	0	Sororin	33,40	Cdk1	44,48	Sororin	Cdk1	113130	983	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	Multiple Levels of Regulation of Sororin by Cdk1 and Aurora_B .
23407681	0	Sortilin_1	22,32	NTR-3	34,39	Sortilin 1	NTR-3	6272	6272	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Ectopic Expression of Sortilin_1 -LRB- NTR-3 -RRB- in Patients with Ovarian_Carcinoma .
26818531	0	Sorting_Nexin_11	0,16	TRPV3	68,73	Sorting Nexin 11	TRPV3	29916	162514	Gene	Gene	Degradation|compound|START_ENTITY Degradation|nmod|END_ENTITY	Sorting_Nexin_11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3 .
22709416	0	Sorting_nexin_12	0,16	BACE1	32,37	Sorting nexin 12	BACE1	29934	23621	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sorting_nexin_12 interacts with BACE1 and regulates BACE1-mediated APP processing .
16712798	0	Sorting_nexin_17	0,16	KRIT1	153,158	Sorting nexin 17	KRIT1	9784	889	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sorting_nexin_17 , a non-self-assembling and a PtdIns -LRB- 3 -RRB- P high class affinity protein , interacts with the cerebral_cavernous_malformation related protein KRIT1 .
22411990	0	Sorting_nexin_27	0,16	multidrug_resistance-associated_protein_4	32,73	Sorting nexin 27	multidrug resistance-associated protein 4	81609	10257	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sorting_nexin_27 interacts with multidrug_resistance-associated_protein_4 -LRB- MRP4 -RRB- and mediates internalization of MRP4 .
22486813	0	Sorting_nexin_5	0,15	Caspase-2	84,93	Sorting nexin 5	Caspase-2	69178(Tax:10090)	12366(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Sorting_nexin_5 of a new diagnostic marker of papillary_thyroid_carcinoma regulates Caspase-2 .
23861900	0	Sorting_nexin_9	0,15	clathrin_heavy_chain	25,45	Sorting nexin 9	clathrin heavy chain	51429	1213	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Sorting_nexin_9 recruits clathrin_heavy_chain to the mitotic spindle for chromosome alignment and segregation .
17681954	0	Sorting_nexin_9	0,15	dynamin_1	31,40	Sorting nexin 9	dynamin 1	51429	1759	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sorting_nexin_9 interacts with dynamin_1 and N-WASP and coordinates synaptic_vesicle_endocytosis .
9030684	0	Sos1	96,100	EGFR	104,108	Sos1	EGFR	20662(Tax:10090)	13649(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Mutation in Sos1 dominantly enhances a weak allele of the EGFR , demonstrating a requirement for Sos1 in EGFR signaling and development .
24497027	0	Sos1	0,4	Erk	38,41	Sos1	Erk	6654	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Sos1 regulates sustained TCR-mediated Erk activation .
8493579	0	Sos1	6,10	GRB2	71,75	Sos1	GRB2	6654	2885	Gene	Gene	START_ENTITY|dep|factor factor|acl:relcl|binds binds|nmod|END_ENTITY	Human Sos1 : a guanine_nucleotide exchange factor for Ras that binds to GRB2 .
18778683	0	Sos1	122,126	Grb2	67,71	Sos1	Grb2	6654	2885	Gene	Gene	adaptor|nmod|START_ENTITY adaptor|nsubj|basis basis|nmod|differential differential|nmod|domains domains|nmod|END_ENTITY	Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine_nucleotide exchange factor Sos1 .
19323566	0	Sos1	63,67	Grb2	15,19	Sos1	Grb2	6654	2885	Gene	Gene	factor|amod|START_ENTITY PXpsiPXR|nmod|factor bind|xcomp|PXpsiPXR bind|nsubj|domains domains|nmod|adaptor adaptor|amod|END_ENTITY	SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner .
24775912	0	Sos1	77,81	Grb2	15,19	Sos1	Grb2	20662(Tax:10090)	14784(Tax:10090)	Gene	Gene	increasing|nmod|START_ENTITY enhances|advcl|increasing enhances|nsubj|SUMOylation SUMOylation|nmod|END_ENTITY	SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1 .
7629138	0	Sos1	35,39	Grb2	54,58	Sos1	Grb2	6654	2885	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Differential interactions of human Sos1 and Sos2 with Grb2 .
8649846	0	Sos1	0,4	Grb2	29,33	Sos1	Grb2	6654	2885	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF_receptor after EGF stimulation .
8816480	0	Sos1	86,90	Grb2	122,126	Sos1	Grb2	6654	2885	Gene	Gene	START_ENTITY|acl:relcl|regulate regulate|nmod|END_ENTITY	Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2 .
24931667	0	Sox-2	46,51	CEACAM1	0,7	Sox-2	CEACAM1	6657	634	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	CEACAM1 promotes melanoma cell growth through Sox-2 .
19304657	0	Sox10	128,133	ARMCX3	41,47	Sox10	ARMCX3	20665(Tax:10090)	71703(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	The armadillo repeat-containing protein , ARMCX3 , physically and functionally interacts with the developmental regulatory factor Sox10 .
26928066	0	Sox10	21,26	Chd7	0,4	Sox10	Chd7	20665(Tax:10090)	320790(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination .
19922439	0	Sox10	40,45	Krox20	14,20	Sox10	Krox20	6663	1959	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells .
15250937	0	Sox10	22,27	Mitf	135,139	Sox10	Mitf	20665(Tax:10090)	17342(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Sox10 with the promoter of murine Dopachrome_Tautomerase -LRB- Dct -RRB- and synergistic activation of Dct expression with Mitf .
20959288	0	Sox10	16,21	Olig2	0,5	Sox10	Olig2	6663	10215	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Olig2 regulates Sox10 expression in oligodendrocyte precursors through an evolutionary conserved distal enhancer .
11032856	0	Sox10	66,71	Pax3	0,4	Sox10	Pax3	6663	5077	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret .
24768923	0	Sox10	140,145	anterior_gradient_2	24,43	Sox10	anterior gradient 2	140616(Tax:7955)	335616(Tax:7955)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of zebrafish anterior_gradient_2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10 .
16684879	0	Sox10	0,5	ciliary_neurotrophic_factor	16,43	Sox10	ciliary neurotrophic factor	20665(Tax:10090)	12803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Sox10 regulates ciliary_neurotrophic_factor gene expression in Schwann cells .
17055661	0	Sox11	28,33	SRY-box_containing_gene_11	0,26	Sox11	SRY-box containing gene 11	20666(Tax:10090)	20666(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	SRY-box_containing_gene_11 -LRB- Sox11 -RRB- transcription factor is required for neuron survival and neurite growth .
22024412	0	Sox11	25,30	Sprr1a	114,120	Sox11	Sprr1a	20666(Tax:10090)	20753(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a .
22331573	0	Sox11	0,5	brain-derived_neurotrophic_factor	16,49	Sox11	brain-derived neurotrophic factor	20666(Tax:10090)	12064(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Sox11 modulates brain-derived_neurotrophic_factor expression in an exon promoter-specific manner .
25704764	0	Sox12	0,5	FoxQ1	26,31	Sox12	FoxQ1	6666	94234	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Sox12 , a direct target of FoxQ1 , promotes hepatocellular_carcinoma metastasis through up-regulating Twist1 and FGFBP1 .
25704764	0	Sox12	0,5	Twist1	100,106	Sox12	Twist1	6666	7291	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Sox12 , a direct target of FoxQ1 , promotes hepatocellular_carcinoma metastasis through up-regulating Twist1 and FGFBP1 .
19003160	0	Sox17	54,59	Cephalic_hedgehog	0,17	Sox17	Cephalic hedgehog	397966(Tax:8355)	378539(Tax:8355)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Cephalic_hedgehog expression is regulated directly by Sox17 in endoderm development of Xenopus_laevis .
25106407	0	Sox17	0,5	KIF14	73,78	Sox17	KIF14	64321	9928	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	Sox17 inhibits hepatocellular_carcinoma progression by downregulation of KIF14 expression .
11518513	0	Sox17	19,24	VegT	0,4	Sox17	VegT	397966(Tax:8355)	397990(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	VegT activation of Sox17 at the midblastula transition alters the response to nodal signals in the vegetal endoderm domain .
27022736	0	Sox17	98,103	microRNA-595	85,97	Sox17	microRNA-595	64321	693180	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Interleukin-22 promotes papillary_thyroid_cancer cell migration and invasion through microRNA-595 / Sox17 axis .
24116102	0	Sox2	0,4	AKT	95,98	Sox2	AKT	20674(Tax:10090)	11651(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|loop loop|acl:relcl|involves involves|dobj|signaling signaling|compound|END_ENTITY	Sox2 expression is regulated by a negative feedback loop in embryonic stem cells that involves AKT signaling and FoxO1 .
25749514	0	Sox2	122,126	AKT	15,18	Sox2	AKT	6657	207	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|DC120 DC120|appos|inhibitor inhibitor|compound|END_ENTITY	DC120 , a novel AKT inhibitor , preferentially suppresses nasopharyngeal_carcinoma cancer stem-like cells by downregulating Sox2 .
21801718	0	Sox2	0,4	Atoh1	27,32	Sox2	Atoh1	378723(Tax:7955)	30303(Tax:7955)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear .
23153495	0	Sox2	0,4	BMP	69,72	Sox2	BMP	6657	649	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Sox2 in the dermal_papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors .
23222817	0	Sox2	92,96	Cathepsin_B	0,11	Sox2	Cathepsin B	6657	1508	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Cathepsin_B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression .
21532573	0	Sox2	0,4	Chd7	21,25	Sox2	Chd7	6657	55636	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes .
26444992	0	Sox2	106,110	FoxM1	0,5	Sox2	FoxM1	6657	2305	Gene	Gene	Regulating|dobj|START_ENTITY END_ENTITY|advcl|Regulating	FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2 .
23712846	0	Sox2	110,114	Lgr4	0,4	Sox2	Lgr4	20674(Tax:10090)	107515(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Lgr4 regulates mammary gland development and stem cell activity through the pluripotency transcription factor Sox2 .
23874697	0	Sox2	0,4	PQBP1	33,38	Sox2	PQBP1	20674(Tax:10090)	54633(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Sox2 transcriptionally regulates PQBP1 , an intellectual_disability-microcephaly causative gene , in neural stem progenitor cells .
18287938	0	Sox2	23,27	Pax6	0,4	Sox2	Pax6	20674(Tax:10090)	18508(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression modulate|nsubj|END_ENTITY	Pax6 directly modulate Sox2 expression in the neural progenitor cells .
18385377	0	Sox2	76,80	Rax	92,95	Sox2	Rax	398000(Tax:8355)	379187(Tax:8355)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Molecular links among the causative genes for ocular_malformation : Otx2 and Sox2 coregulate Rax expression .
25940188	0	Sox2	0,4	Sirt1	22,27	Sox2	Sirt1	20674(Tax:10090)	93759(Tax:10090)	Gene	Gene	Deacetylation|compound|START_ENTITY Deacetylation|nmod|END_ENTITY	Sox2 Deacetylation by Sirt1 Is Involved in Mouse Somatic Reprogramming .
22902753	0	Sox2	0,4	Sox21	18,23	Sox2	Sox21	20674(Tax:10090)	223227(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells .
26292759	0	Sox2	16,20	Ube2s	0,5	Sox2	Ube2s	20674(Tax:10090)	77891(Tax:10090)	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Ube2s regulates Sox2 stability and mouse ES cell maintenance .
24885403	0	Sox2	15,19	YB-1	0,4	Sox2	YB-1	6657	4904	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast_cancer cells .
24291232	0	Sox2	93,97	b-Catenin	0,9	Sox2	b-Catenin	6657	1499	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	b-Catenin , a Sox2 binding partner , regulates the DNA binding and transcriptional activity of Sox2 in breast_cancer cells .
23311397	0	Sox2	60,64	bone_morphogenetic_protein-4	10,38	Sox2	bone morphogenetic protein-4	6657	652	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of bone_morphogenetic_protein-4 on the expression of Sox2 , Oct-4 , and c-Myc in human periodontal ligament cells during long-term culture .
26447186	0	Sox2	63,67	c-Myc	83,88	Sox2	c-Myc	6657	4609	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Galectin-3 modulates the EGFR signaling-mediated regulation of Sox2 expression via c-Myc in lung_cancer .
20537983	0	Sox2	0,4	eukaryotic_initiation_factor_4E	37,68	Sox2	eukaryotic initiation factor 4E	6657	1977	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Sox2 is translationally activated by eukaryotic_initiation_factor_4E in human glioma-initiating cells .
24384842	0	Sox2	69,73	miR-126	0,7	Sox2	miR-126	6657	406913	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	miR-126 functions as a tumor suppressor in osteosarcoma by targeting Sox2 .
25585946	0	Sox2	120,124	miR-126	0,7	Sox2	miR-126	6657	406913	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	miR-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular_carcinoma cells partially by targeting Sox2 .
24763828	0	Sox2	63,67	nucleostemin	28,40	Sox2	nucleostemin	6657	26354	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric_adenocarcinoma .
23217425	0	Sox2	29,33	p27	0,3	Sox2	p27	20674(Tax:10090)	12576(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	p27 -LRB- Kip1 -RRB- directly represses Sox2 during embryonic stem cell differentiation .
22902753	0	Sox21	18,23	Sox2	0,4	Sox21	Sox2	223227(Tax:10090)	20674(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells .
20043898	0	Sox3	26,30	FGF	44,47	Sox3	FGF	374019(Tax:9031)	395432(Tax:9031)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling influences the neurogenic and non-neurogenic domains in the chick otic placode .
22261149	0	Sox3	50,54	XSeb4R	24,30	Sox3	XSeb4R	399335(Tax:8355)	398603(Tax:8355)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The RNA-binding protein XSeb4R regulates maternal Sox3 at the posttranscriptional level during maternal-zygotic_transition in Xenopus .
18992330	0	Sox3	8,12	sox2	23,27	Sox3	sox2	399335(Tax:8355)	398000(Tax:8355)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives .
22627767	0	Sox4	0,4	CREB	21,25	Sox4	CREB	20677(Tax:10090)	12912(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Sox4 cooperates with CREB in myeloid transformation .
21538160	0	Sox4	0,4	Cx43	74,78	Sox4	Cx43	336346(Tax:7955)	30236(Tax:7955)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43 .
25059387	0	Sox4	0,4	Cyr61	18,23	Sox4	Cyr61	6659	3491	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Sox4 up-regulates Cyr61 expression in colon_cancer cells .
16204320	0	Sox4	0,4	Evi1	21,25	Sox4	Evi1	20677(Tax:10090)	14013(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Sox4 cooperates with Evi1 in AKXD-23 myeloid_tumors via transactivation of proviral LTR .
23764001	0	Sox4	0,4	Ezh2	79,83	Sox4	Ezh2	6659	2146	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|transition transition|nmod|expression expression|amod|END_ENTITY	Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming .
22231735	0	Sox4	0,4	b-catenin	42,51	Sox4	b-catenin	6659	1499	Gene	Gene	functions|amod|START_ENTITY functions|nmod|regulator regulator|nmod|END_ENTITY	Sox4 functions as a positive regulator of b-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial_carcinomas .
25101494	0	Sox5	26,30	Catsper1	49,57	Sox5	Catsper1	20678(Tax:10090)	225865(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression .
23663701	0	Sox6	51,55	Trip12	0,6	Sox6	Trip12	55553	9320	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Trip12 , a HECT domain E3 ubiquitin ligase , targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells .
24066135	0	Sox6	0,4	macrophage_migration_inhibitory_factor	22,60	Sox6	macrophage migration inhibitory factor	20679(Tax:10090)	17319(Tax:10090)	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Sox6 up-regulation by macrophage_migration_inhibitory_factor promotes survival and maintenance of mouse neural stem/progenitor cells .
24762086	0	Sox7	0,4	ETV2	21,25	Sox7	ETV2	83595	2116	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Sox7 is regulated by ETV2 during cardiovascular development .
19476490	0	Sox9	44,48	AP-2epsilon	59,70	Sox9	AP-2epsilon	6662	339488	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The cartilage-specific transcription factor Sox9 regulates AP-2epsilon expression in chondrocytes .
21346191	0	Sox9	23,27	Arid5a	0,6	Sox9	Arid5a	6662	10865	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription .
15908194	0	Sox9	24,28	CCAAT-binding_factor	45,65	Sox9	CCAAT-binding factor	6662	10153	Gene	Gene	promoter|amod|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the human Sox9 promoter by the CCAAT-binding_factor .
25623042	0	Sox9	44,48	EGFR	13,17	Sox9	EGFR	20682(Tax:10090)	13649(Tax:10090)	Gene	Gene	Transcription|compound|START_ENTITY Signaling|nmod|Transcription Signaling|compound|END_ENTITY	NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal_Transdifferentiation_in_the_Pancreas .
21991335	0	Sox9	26,30	Exportin_4	0,10	Sox9	Exportin 4	6662	64328	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Exportin_4 interacts with Sox9 through the HMG Box and inhibits the DNA binding of Sox9 .
17913788	0	Sox9	24,28	HIF1alpha	0,9	Sox9	HIF1alpha	20682(Tax:10090)	15251(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis .
20079164	0	Sox9	23,27	Interleukin-1	0,13	Sox9	Interleukin-1	6662	3552	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear_factor-kappaB in the cultured human intervertebral disc cells .
25623042	0	Sox9	44,48	NFATc1	0,6	Sox9	NFATc1	20682(Tax:10090)	18018(Tax:10090)	Gene	Gene	Transcription|compound|START_ENTITY Signaling|nmod|Transcription Signaling|compound|END_ENTITY	NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal_Transdifferentiation_in_the_Pancreas .
26697077	0	Sox9	17,21	NFATc4	0,6	Sox9	NFATc4	6662	4776	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic_Cancer_Initiation .
11869287	0	Sox9	65,69	Noggin	42,48	Sox9	Noggin	20682(Tax:10090)	18121(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The bone morphogenetic protein antagonist Noggin is regulated by Sox9 during endochondral differentiation .
15699338	0	Sox9	85,89	PGC-1alpha	28,38	Sox9	PGC-1alpha	6662	10891	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9 .
19254573	0	Sox9	73,77	Pref-1	0,6	Sox9	Pref-1	20682(Tax:10090)	13386(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9 .
19470758	0	Sox9	32,36	RhoA	69,73	Sox9	RhoA	6662	387	Gene	Gene	activity|nmod|START_ENTITY regulated|nsubjpass|activity regulated|nmod|signaling signaling|compound|END_ENTITY	The transcriptional activity of Sox9 in chondrocytes is regulated by RhoA signaling and actin polymerization .
22523547	0	Sox9	58,62	SRY	22,25	Sox9	SRY	6662	6736	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Synergistic effect of SRY and its direct target , WDR5 , on Sox9 expression .
22128028	0	Sox9	64,68	Sf1	46,49	Sox9	Sf1	6662	2516	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Wnt signaling in ovarian development inhibits Sf1 activation of Sox9 via the Tesco enhancer .
20034104	0	Sox9	14,18	Shh	38,41	Sox9	Shh	6662	6469	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of Sox9 by Sonic_Hedgehog -LRB- Shh -RRB- is essential for patterning and formation of tracheal cartilage .
22046352	0	Sox9	0,4	Spp1	33,37	Sox9	Spp1	20682(Tax:10090)	20750(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes .
18624952	0	Sox9	141,145	Sry-related_HMG_box_9	118,139	Sox9	Sry-related HMG box 9	6662	6662	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Injectable growth/differentiation _ factor-5-recombinant human collagen composite induces endochondral ossification via Sry-related_HMG_box_9 -LRB- Sox9 -RRB- expression and angiogenesis in murine calvariae .
19201862	0	Sox9	38,42	TACE	28,32	Sox9	TACE	20682(Tax:10090)	11491(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF .
24661907	0	Sox9	0,4	TUBB3	25,30	Sox9	TUBB3	6662	10381	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nummod|END_ENTITY	Sox9 and Hif-2a regulate TUBB3 gene expression and affect ovarian_cancer_aggressiveness .
22532563	0	Sox9	117,121	Twist1	44,50	Sox9	Twist1	6662	7291	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Basic helix-loop-helix transcription factor Twist1 inhibits transactivator function of master chondrogenic regulator Sox9 .
17359721	0	Sox9	84,88	interleukin-1	26,39	Sox9	interleukin-1	6662	3552	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The regulation effect of interleukin-1 on expression of cartilage specificity gene Sox9 mRNA in the human intervertebral discs -RSB- .
20079164	0	Sox9	23,27	nuclear_factor-kappaB	64,85	Sox9	nuclear factor-kappaB	6662	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear_factor-kappaB in the cultured human intervertebral disc cells .
18950725	0	Sox9a	0,5	ff1a	20,24	Sox9a	ff1a	60641(Tax:7955)	30749(Tax:7955)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Sox9a regulation of ff1a in zebrafish -LRB- Danio_rerio -RRB- suggests an involvement of ff1a in cartilage development .
18950725	0	Sox9a	0,5	ff1a	79,83	Sox9a	ff1a	60641(Tax:7955)	30749(Tax:7955)	Gene	Gene	regulation|amod|START_ENTITY suggests|nsubj|regulation suggests|dobj|involvement involvement|nmod|END_ENTITY	Sox9a regulation of ff1a in zebrafish -LRB- Danio_rerio -RRB- suggests an involvement of ff1a in cartilage development .
19772640	0	Sp1	21,24	ADAM17	33,39	Sp1	ADAM17	6667	6868	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia .
17597815	0	Sp1	8,11	ATP2A2	38,44	Sp1	ATP2A2	6667	488	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes .
15955096	0	Sp1	45,48	ATP2C1	30,36	Sp1	ATP2C1	6667	27032	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey_disease keratinocytes .
26448047	0	Sp1	3,6	Androgen_Receptor	77,94	Sp1	Androgen Receptor	6667	367	Gene	Gene	Modulated|nsubj|START_ENTITY Modulated|nmod|Activity Activity|compound|END_ENTITY	An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen_Receptor Promoter Activity in Prostate_Cancer Cells .
14701757	0	Sp1	91,94	BACE1	30,35	Sp1	BACE1	6667	23621	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of BACE1 , the beta-amyloid_precursor_protein beta-secretase , by Sp1 .
19111069	0	Sp1	49,52	BRD7	30,34	Sp1	BRD7	6667	29117	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of BRD7 expression by Sp1 and c-Myc .
24680773	0	Sp1	0,3	BRK1	32,36	Sp1	BRK1	6667	55845	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Sp1 transcriptionally regulates BRK1 expression in non-small_cell_lung_cancer cells .
10373535	0	Sp1	21,24	C/EBPalpha	32,42	Sp1	C/EBPalpha	6667	1050	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Repressive effect of Sp1 on the C/EBPalpha gene promoter : role in adipocyte differentiation .
17965828	0	Sp1	32,35	C/EBPdelta	69,79	Sp1	C/EBPdelta	20683(Tax:10090)	12609(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of transcriptional factors Sp1 , c-Rel , and c-Jun in LPS-induced C/EBPdelta gene expression of mouse macrophages .
27050367	0	Sp1	103,106	C4b-binding_protein_a	41,62	Sp1	C4b-binding protein a	6667	722	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|advcl|activating	Hepatitis_B_virus X protein up-regulates C4b-binding_protein_a through activating transcription factor Sp1 in protection of hepatoma cells from complement attack .
22718198	0	Sp1	97,100	CCR7	30,34	Sp1	CCR7	6667	1236	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast_cancer cells .
20384626	0	Sp1	21,24	CD147	76,81	Sp1	CD147	6667	682	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung_cancer .
20629990	0	Sp1	74,77	CD147	38,43	Sp1	CD147	6667	682	Gene	Gene	binding|amod|START_ENTITY increasing|dobj|binding END_ENTITY|advcl|increasing	Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular_carcinoma .
11369656	0	Sp1	43,46	CD99	0,4	Sp1	CD99	6667	4267	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr_virus latent membrane protein 1 through nuclear factor-kappaB .
10550452	0	Sp1	19,22	COL1A1	39,45	Sp1	COL1A1	6667	1277	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Polymorphism at an Sp1 binding site of COL1A1 and bone_mineral_density in premenopausal female twins and elderly fracture patients .
11522109	0	Sp1	29,32	COL1A1	58,64	Sp1	COL1A1	6667	1277	Gene	Gene	site|amod|START_ENTITY method|nmod|site polymorphism|nsubj|method polymorphism|nmod|gene gene|compound|END_ENTITY	New PCR-based method for the Sp1 site polymorphism in the COL1A1 gene .
11547832	0	Sp1	7,10	COL1A1	0,6	Sp1	COL1A1	6667	1277	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone_loss .
14613485	0	Sp1	87,90	COL1A1	35,41	Sp1	COL1A1	6667	1277	Gene	Gene	factors|compound|START_ENTITY interacting|nmod|factors acts|advcl|interacting acts|nmod|repressor repressor|nmod|expression expression|compound|END_ENTITY	B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts .
14734826	0	Sp1	81,84	COL1A1	105,111	Sp1	COL1A1	6667	1277	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Rapid genotyping of the osteoporosis-associated polymorphic transcription factor Sp1 binding site in the COL1A1 gene by pyrosequencing .
15241219	0	Sp1	33,36	COL1A1	66,72	Sp1	COL1A1	6667	1277	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	Association of otosclerosis with Sp1 binding site polymorphism in COL1A1 gene : evidence for a shared genetic etiology with osteoporosis .
15466008	0	Sp1	33,36	COL1A1	58,64	Sp1	COL1A1	6667	1277	Gene	Gene	sites|amod|START_ENTITY sites|nmod|gene gene|compound|END_ENTITY	Common variants at the PCOL2 and Sp1 binding sites of the COL1A1 gene and their interactive effect influence bone_mineral_density in Caucasians .
15952128	0	Sp1	56,59	COL1A1	77,83	Sp1	COL1A1	6667	1277	Gene	Gene	sites|amod|START_ENTITY sites|nmod|gene gene|nummod|END_ENTITY	-LSB- Association analysis on the polymorphisms of PCOL2 and Sp1 binding sites of COL1A1 gene and the congenital_dislocation_of_the_hip in Chinese population -RSB- .
17332715	0	Sp1	25,28	COL1A1	17,23	Sp1	COL1A1	6667	1277	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|amod|Collagen_type_1 Collagen_type_1|dep|END_ENTITY	Collagen_type_1 -LRB- COL1A1 -RRB- Sp1 binding site polymorphism is associated with osteoporotic_fractures but not with bone density in post-menopausal women from the Canary Islands : a preliminary study .
18694864	0	Sp1	136,139	COL1A1	25,31	Sp1	COL1A1	6667	1277	Gene	Gene	site|amod|START_ENTITY that|nmod|site associated|nmod|that associated|nsubjpass|polymorphism polymorphism|compound|END_ENTITY	A novel , non-functional , COL1A1 polymorphism is not associated with lumbar_disk_disease in young male Greek subjects unlike that of the Sp1 site .
22057139	0	Sp1	65,68	COL1A1	89,95	Sp1	COL1A1	6667	1277	Gene	Gene	site|amod|START_ENTITY site|nmod|gene gene|compound|END_ENTITY	A haplotype derived from the common variants at the -1997 G/T and Sp1 binding site of the COL1A1 gene influences risk of postmenopausal_osteoporosis in India .
24398012	0	Sp1	3,6	COL1A1	40,46	Sp1	COL1A1	6667	1277	Gene	Gene	gene|nsubj|START_ENTITY gene|dep|polymorphism polymorphism|nmod|END_ENTITY	Is Sp1 binding site polymorphism within COL1A1 gene associated with tennis_elbow ?
24566004	0	Sp1	52,55	COL1A1	44,50	Sp1	COL1A1	6667	1277	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Combined effects of collagen_type_I_alpha1 -LRB- COL1A1 -RRB- Sp1 polymorphism and osteoporosis risk factors on bone_mineral_density in Turkish postmenopausal women .
9840444	0	Sp1	95,98	COL1A1	72,78	Sp1	COL1A1	6667	1277	Gene	Gene	elements|amod|START_ENTITY Modulation|dep|elements Modulation|nmod|expression expression|nmod|gene gene|appos|END_ENTITY	Modulation of basal expression of the human alpha1 -LRB- I -RRB- procollagen gene -LRB- COL1A1 -RRB- by tandem NF-1 / Sp1 promoter elements in normal human dermal fibroblasts .
11420783	0	Sp1	4,7	COLIA1	8,14	Sp1	COLIA1	6667	1277	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	The Sp1 COLIA1 gene polymorphism , and not vitamin_D_receptor or estrogen_receptor gene polymorphisms , determines bone_mineral_density in postmenopausal Greek women .
9738510	0	Sp1	3,6	COLIA1	40,46	Sp1	COLIA1	6667	1277	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	An Sp1 binding site polymorphism in the COLIA1 gene predicts osteoporotic_fractures in both men and women .
10383457	0	Sp1	8,11	CYP11A	71,77	Sp1	CYP11A	540741(Tax:9913)	338048(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene .
11470525	0	Sp1	83,86	CYP7B1	72,78	Sp1	CYP7B1	6667	9420	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of human oxysterol_7_alpha-hydroxylase gene -LRB- CYP7B1 -RRB- by Sp1 .
21242964	0	Sp1	46,49	Cdc25B	0,6	Sp1	Cdc25B	6667	994	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors .
23160377	0	Sp1	89,92	Cdc25B	53,59	Sp1	Cdc25B	6667	994	Gene	Gene	releasing|dobj|START_ENTITY promotes|advcl|releasing promotes|dobj|upregulation upregulation|nmod|END_ENTITY	Doxorubicin promotes transcriptional upregulation of Cdc25B in cancer cells by releasing Sp1 from the promoter .
23159876	0	Sp1	58,61	Col1a1	16,22	Sp1	Col1a1	20683(Tax:10090)	12842(Tax:10090)	Gene	Gene	sites|amod|START_ENTITY binding|nmod|sites regions|amod|binding induces|nmod|regions induces|dobj|expression expression|amod|END_ENTITY	Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions .
15883203	0	Sp1	132,135	Cyclooxygenase-2	0,16	Sp1	Cyclooxygenase-2	6667	5743	Gene	Gene	proteins|amod|START_ENTITY degradation|nmod|proteins inhibitors|nmod|degradation inhibitors|nsubj|END_ENTITY	Cyclooxygenase-2 inhibitors decrease vascular_endothelial_growth_factor expression in colon_cancer cells by enhanced degradation of Sp1 and Sp4 proteins .
22718198	0	Sp1	97,100	Cyclooxygenase-2	0,16	Sp1	Cyclooxygenase-2	6667	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cyclooxygenase-2 up-regulates CCR7 expression via AKT-mediated phosphorylation and activation of Sp1 in breast_cancer cells .
26182937	0	Sp1	8,11	Cytochrome_P450	102,117	Sp1	Cytochrome P450	6667	4051	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Sp1 , HNF1a , and PXR in the Basal and Rifampicin Induced Transcriptional Regulation of Porcine Cytochrome_P450 3A46 .
24530422	0	Sp1	15,18	DNA-PKcs	39,47	Sp1	DNA-PKcs	6667	5591	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA_ligase_IV transcription of daunorubicin-resistant_leukemia cell lines .
16806531	0	Sp1	12,15	DPYD	44,48	Sp1	DPYD	6667	1806	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	The role of Sp1 and Sp3 in the constitutive DPYD gene expression .
12071960	0	Sp1	49,52	Dnmt1	35,40	Sp1	Dnmt1	20683(Tax:10090)	13433(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins .
15550398	0	Sp1	72,75	Dp71	11,15	Sp1	Dp71	20683(Tax:10090)	13405(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY myogenesis|dep|role down-regulated|nmod|myogenesis down-regulated|nsubjpass|expression expression|amod|END_ENTITY	Dystrophin Dp71 expression is down-regulated during myogenesis : role of Sp1 and Sp3 on the Dp71 promoter activity .
15550398	0	Sp1	72,75	Dp71	91,95	Sp1	Dp71	20683(Tax:10090)	13405(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY myogenesis|dep|role down-regulated|nmod|myogenesis down-regulated|nmod|activity activity|amod|END_ENTITY	Dystrophin Dp71 expression is down-regulated during myogenesis : role of Sp1 and Sp3 on the Dp71 promoter activity .
19943855	0	Sp1	91,94	Dp71	111,115	Sp1	Dp71	20683(Tax:10090)	13405(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Induction of dystrophin Dp71 expression during neuronal differentiation : opposite roles of Sp1 and AP2alpha in Dp71 promoter activity .
19943855	0	Sp1	91,94	Dp71	24,28	Sp1	Dp71	20683(Tax:10090)	13405(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY Induction|dep|roles Induction|nmod|expression expression|amod|END_ENTITY	Induction of dystrophin Dp71 expression during neuronal differentiation : opposite roles of Sp1 and AP2alpha in Dp71 promoter activity .
25024375	0	Sp1	74,77	DsbA-L	23,29	Sp1	DsbA-L	20683(Tax:10090)	76263(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Negative regulation of DsbA-L gene expression by the transcription factor Sp1 .
19115249	0	Sp1	98,101	E2F1	27,31	Sp1	E2F1	6667	1869	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites .
12220517	0	Sp1	12,15	Erk2	37,41	Sp1	Erk2	20683(Tax:10090)	26413(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of Sp1 in BMP2-up-regulated Erk2 gene expression .
12746293	0	Sp1	18,21	Estrogen_receptor	0,17	Sp1	Estrogen receptor	6667	2099	Gene	Gene	complexes|amod|START_ENTITY required|nsubjpass|complexes END_ENTITY|parataxis|required	Estrogen_receptor / Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast_cancer cells .
11970950	0	Sp1	86,89	Ets-1	0,5	Sp1	Ets-1	6667	2113	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Ets-1 positively regulates Fas_ligand transcription via cooperative interactions with Sp1 .
16157598	0	Sp1	0,3	Ets-1	27,32	Sp1	Ets-1	20683(Tax:10090)	23871(Tax:10090)	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	Sp1 is a co-activator with Ets-1 , and Net is an important repressor of the transcription of CTP : phosphocholine_cytidylyltransferase_alpha .
20150555	0	Sp1	71,74	FGF-2	63,68	Sp1	FGF-2	20683(Tax:10090)	14173(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dep|phosphorylation	TRAIL promotes VSMC proliferation and neointima formation in a FGF-2 - , Sp1 phosphorylation - , and NFkappaB-dependent manner .
15694838	0	Sp1	45,48	FasL	20,24	Sp1	FasL	6667	356	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	p21 -LRB- Waf1/Cip1 -RRB- and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli .
18378679	0	Sp1	111,114	Fc_receptor_gamma-chain	26,49	Sp1	Fc receptor gamma-chain	6667	2207	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Cooperative regulation of Fc_receptor_gamma-chain gene expression by multiple transcription factors , including Sp1 , GABP , and Elf-1 .
22511764	0	Sp1	113,116	FoxO1	0,5	Sp1	FoxO1	20683(Tax:10090)	56458(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	FoxO1 inhibits sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene expression via transcription factors Sp1 and SREBP-1c .
7739528	0	Sp1	124,127	GATA-1	83,89	Sp1	GATA-1	6667	2623	Gene	Gene	synergy|nmod|START_ENTITY synergy|nmod|END_ENTITY	Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Kr ppel family proteins Sp1 and EKLF .
26828265	0	Sp1	82,85	HBXIP	16,21	Sp1	HBXIP	6667	10542	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|advcl|activating	The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast_cancer cells .
12473536	0	Sp1	0,3	HGF_receptor	59,71	Sp1	HGF receptor	20683(Tax:10090)	17295(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Sp1 and Sp3 transcription factors synergistically regulate HGF_receptor gene expression in kidney .
26689994	0	Sp1	145,148	HiF-1a	107,113	Sp1	HiF-1a	6667	3091	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Monoamine_oxidase_B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1a and with transcription factors Sp1 and Sp3 .
23176121	0	Sp1	29,32	HuR	57,60	Sp1	HuR	6667	1994	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of transcription factor Sp1 and RNA binding protein HuR in the downregulation of Dr + Escherichia_coli receptor protein decay accelerating factor -LRB- DAF or CD55 -RRB- by nitric_oxide .
11043541	0	Sp1	80,83	Huntingtin	57,67	Sp1	Huntingtin	6667	3064	Gene	Gene	sites|amod|START_ENTITY promoter|nmod|sites promoter|amod|END_ENTITY	12-O-tetradecanoyl-phorbol-13-acetate down-regulates the Huntingtin promoter at Sp1 sites .
11788788	0	Sp1	116,119	ICAM-1	53,59	Sp1	ICAM-1	20683(Tax:10090)	15894(Tax:10090)	Gene	Gene	decreasing|dobj|START_ENTITY level|acl|decreasing expression|nmod|level expression|compound|END_ENTITY	Nitric_oxide inhibits endothelial IL-1 -LSB- beta -RSB- - induced ICAM-1 gene expression at the transcriptional level decreasing Sp1 and AP-1 activity .
20383178	0	Sp1	72,75	IL-24	55,60	Sp1	IL-24	6667	11009	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	HDAC4 inhibits the transcriptional activation of mda-7 / IL-24 induced by Sp1 .
2083254	0	Sp1	0,3	IL-2_receptor_alpha	14,33	Sp1	IL-2 receptor alpha	6667	3559	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Sp1 represses IL-2_receptor_alpha chain gene expression .
9154804	0	Sp1	47,50	K3_keratin	14,24	Sp1	K3 keratin	100351317(Tax:9986)	100353668(Tax:9986)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of K3_keratin gene transcription by Sp1 and AP-2 in differentiating rabbit corneal epithelial cells .
23047008	0	Sp1	122,125	Keap1	61,66	Sp1	Keap1	6667	9817	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	A possible gene silencing mechanism : hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung_cancer cells .
24018208	0	Sp1	12,15	LMX1A	46,51	Sp1	LMX1A	6667	4009	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	The role of Sp1 and EZH2 in the regulation of LMX1A in cervical cancer cells .
27004687	0	Sp1	61,64	LRRK2	14,19	Sp1	LRRK2	6667	120892	Gene	Gene	promoter|nmod|START_ENTITY promoter|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of LRRK2 promoter activity and gene expression by Sp1 .
17460244	0	Sp1	82,85	MMP-9	107,112	Sp1	MMP-9	6667	4318	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells .
10497252	0	Sp1	54,57	MXI1	14,18	Sp1	MXI1	6667	4601	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of MXI1 , a Myc antagonist , is regulated by Sp1 and AP2 .
22253285	0	Sp1	47,50	Mfn2	31,35	Sp1	Mfn2	6667	9927	Gene	Gene	depends|nmod|START_ENTITY depends|nsubj|activity activity|nmod|END_ENTITY	The promoter activity of human Mfn2 depends on Sp1 in vascular smooth muscle cells .
25012245	0	Sp1	72,75	MicroRNA-27b	0,12	Sp1	MicroRNA-27b	6667	407019	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	MicroRNA-27b suppresses growth and invasion of NSCLC cells by targeting Sp1 .
10336677	0	Sp1	64,67	NR2C	47,51	Sp1	NR2C	20683(Tax:10090)	14813(Tax:10090)	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Regulation of the murine NMDA-receptor-subunit NR2C promoter by Sp1 and fushi_tarazu_factor1 -LRB- FTZ-F1 -RRB- homologues .
2926813	0	Sp1	63,66	Nuclear_factor_I	0,16	Sp1	Nuclear factor I	6667	4782	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	Nuclear_factor_I can functionally replace transcription factor Sp1 in a U2 small nuclear RNA gene enhancer .
23537647	0	Sp1	76,79	PDGFB	34,39	Sp1	PDGFB	6667	5155	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|acl|activating	The oncoprotein HBXIP upregulates PDGFB via activating transcription factor Sp1 to promote the proliferation of breast_cancer cells .
15905415	0	Sp1	66,69	PEPT1	126,131	Sp1	PEPT1	6667	6564	Gene	Gene	functions|amod|START_ENTITY functions|nmod|regulator regulator|nmod|END_ENTITY	Characterization of the human peptide transporter PEPT1 promoter : Sp1 functions as a basal transcriptional regulator of human PEPT1 .
19114034	0	Sp1	75,78	PTEN	0,4	Sp1	PTEN	6667	5728	Gene	Gene	activity|nmod|START_ENTITY decreasing|dobj|activity downregulates|advcl|decreasing downregulates|nsubj|END_ENTITY	PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1 .
22810004	0	Sp1	119,122	PTEN	189,193	Sp1	PTEN	6667	5728	Gene	Gene	START_ENTITY|nmod|homolog homolog|acl|deleted deleted|nmod|chromosome chromosome|appos|END_ENTITY	Estrogen receptor beta -LRB- ERb -RRB- produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 -LRB- PTEN -RRB- promoter gene .
23104175	0	Sp1	11,14	PTEN	24,28	Sp1	PTEN	6667	5728	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion .
23104175	0	Sp1	11,14	PTEN	59,63	Sp1	PTEN	6667	5728	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|promoter promoter|amod|binding binding|nmod|END_ENTITY	Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion .
18579560	0	Sp1	0,3	PUMA	21,25	Sp1	PUMA	6667	27113	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Sp1 and p73 activate PUMA following serum starvation .
12044781	0	Sp1	57,60	RAG-2	39,44	Sp1	RAG-2	20683(Tax:10090)	19374(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors .
21179468	0	Sp1	38,41	REST	30,34	Sp1	REST	20683(Tax:10090)	19712(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of REST by Sp1 in Huntington 's _ disease models .
12818568	0	Sp1	21,24	SERCA2	35,41	Sp1	SERCA2	24790(Tax:10116)	29693(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Transcription factor Sp1 regulates SERCA2 gene expression in pressure-overloaded hearts : a study using in vivo direct gene transfer into living myocardium .
14613864	0	Sp1	0,3	SERCA2	81,87	Sp1	SERCA2	6667	488	Gene	Gene	factors|compound|START_ENTITY required|nsubjpass|factors required|nmod|trans-activation trans-activation|nmod|promoter promoter|compound|END_ENTITY	Sp1 and Sp3 transcription factors are required for trans-activation of the human SERCA2 promoter in cardiomyocytes .
15129808	0	Sp1	112,115	SF-1	77,81	Sp1	SF-1	6667	7536	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Characterization of binding between SF-1 and Sp1 : predominant interaction of SF-1 with the N-terminal region of Sp1 .
20060848	0	Sp1	34,37	SGLT1	55,60	Sp1	SGLT1	20683(Tax:10090)	20537(Tax:10090)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Cadmium down-regulation of kidney Sp1 binding to mouse SGLT1 and SGLT2 gene promoters : possible reaction of cadmium with the zinc finger domain of Sp1 .
20160399	0	Sp1	64,67	SIRT1	35,40	Sp1	SIRT1	6667	23411	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1 .
16623715	0	Sp1	27,30	SOX10	0,5	Sp1	SOX10	6667	6663	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	SOX10 , in combination with Sp1 , regulates the endothelin_receptor_type_B gene in human melanocyte lineage cells .
17289023	0	Sp1	41,44	SOX9	24,28	Sp1	SOX9	6667	6662	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the human SOX9 promoter by Sp1 and CREB .
1662663	0	Sp1	4,7	SP1	35,38	Sp1	SP1	24790(Tax:10116)	6667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Sp1 transcription factor gene -LRB- SP1 -RRB- and the 1,25-dihydroxyvitamin _ D3 receptor gene -LRB- VDR -RRB- are colocalized on human chromosome arm 12q and rat chromosome 7 .
25483064	0	Sp1	123,126	STRAP	10,15	Sp1	STRAP	20683(Tax:10090)	20901(Tax:10090)	Gene	Gene	modulating|dobj|START_ENTITY END_ENTITY|advcl|modulating	Oncogenic STRAP functions as a novel negative regulator of E-cadherin and p21 -LRB- Cip1 -RRB- by modulating the transcription factor Sp1 .
11013220	0	Sp1	38,41	Smad2	0,5	Sp1	Smad2	6667	4087	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Smad2 , Smad3 and Smad4 cooperate with Sp1 to induce p15 -LRB- Ink4B -RRB- transcription in response to TGF-beta .
12954773	0	Sp1	85,88	Sp3	55,58	Sp1	Sp3	6667	6670	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|efficiently efficiently|compound|END_ENTITY	Stability of the Sp3-DNA complex is promoter-specific : Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites .
26352013	0	Sp1	0,3	Sp3	20,23	Sp1	Sp3	6667	6670	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Sp1 cooperates with Sp3 to upregulate MALAT1 expression in human hepatocellular_carcinoma .
26967243	0	Sp1	47,50	Sp3	52,55	Sp1	Sp3	6667	6670	Gene	Gene	transcription|dobj|START_ENTITY genes|ccomp|transcription genes|nsubj|END_ENTITY	Specificity protein -LRB- Sp -RRB- transcription factors Sp1 , Sp3 and Sp4 are non-oncogene addiction genes in cancer cells .
8845379	0	Sp1	0,3	Sp3	83,86	Sp1	Sp3	31913(Tax:7227)	31917(Tax:7227)	Gene	Gene	trans-activation|amod|START_ENTITY repressed|nsubj|trans-activation repressed|nmod|END_ENTITY	Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 .
9006959	1	Sp1	61,64	Sp3	66,69	Sp1	Sp3	6667	6670	Gene	Gene	necessary|advmod|START_ENTITY necessary|nsubj|factors factors|amod|END_ENTITY	Sp1 , Sp3 , TTF-1 , and HNF-3alpha transcription factors are necessary for lung cell-specific activation of SP-B gene transcription .
9115370	0	Sp1	91,94	Sp3	21,24	Sp1	Sp3	24790(Tax:10116)	367846(Tax:10116)	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	Transcription factor Sp3 antagonizes activation of the ornithine_decarboxylase promoter by Sp1 .
9867805	0	Sp1	56,59	Sp3	0,3	Sp1	Sp3	6667	6670	Gene	Gene	competing|nmod|START_ENTITY repress|advcl|competing repress|nsubj|END_ENTITY	Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter .
23184467	0	Sp1	22,25	Stat6	0,5	Sp1	Stat6	6667	6778	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Stat6 cooperates with Sp1 in controlling breast_cancer cell proliferation by modulating the expression of p21 -LRB- Cip1/WAF1 -RRB- and p27 -LRB- Kip1 -RRB- .
21645329	0	Sp1	22,25	TRPV1	43,48	Sp1	TRPV1	24790(Tax:10116)	83810(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nummod|END_ENTITY	Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons .
9006959	1	Sp1	61,64	TTF-1	71,76	Sp1	TTF-1	6667	7270	Gene	Gene	necessary|advmod|START_ENTITY necessary|nsubj|factors factors|amod|END_ENTITY	Sp1 , Sp3 , TTF-1 , and HNF-3alpha transcription factors are necessary for lung cell-specific activation of SP-B gene transcription .
7592908	0	Sp1	112,115	Transforming_growth_factor_beta	0,31	Sp1	Transforming growth factor beta	6667	7040	Gene	Gene	site|amod|START_ENTITY activates|nmod|site activates|nsubj|END_ENTITY	Transforming_growth_factor_beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site .
18996094	0	Sp1	119,122	Tumor_necrosis_factor_alpha	0,27	Sp1	Tumor necrosis factor alpha	6667	7124	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1 .
24728340	0	Sp1	118,121	WNT-5A	66,72	Sp1	WNT-5A	6667	7474	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	TGF-b-activated_kinase_1 -LRB- TAK1 -RRB- signaling regulates TGF-b-induced WNT-5A expression in airway smooth muscle cells via Sp1 and b-catenin .
15094066	0	Sp1	0,3	Waf1	70,74	Sp1	Waf1	6667	1026	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Sp1 is involved in the transcriptional activation of p16 -LRB- INK4 -RRB- by p21 -LRB- Waf1 -RRB- in HeLa cells .
17719138	0	Sp1	68,71	adrenomedullin	36,50	Sp1	adrenomedullin	6667	133	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha .
15661808	0	Sp1	36,39	androgen_receptor	87,104	Sp1	androgen receptor	6667	367	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen_receptor in human prostate_cancer cells .
18430409	0	Sp1	96,99	androgen_receptor	59,76	Sp1	androgen receptor	6667	367	Gene	Gene	activity|amod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Inhibitory effect of acetyl-11-keto-beta-boswellic_acid on androgen_receptor by interference of Sp1 binding activity in prostate_cancer cells .
20148354	0	Sp1	99,102	androgen_receptor	19,36	Sp1	androgen receptor	6667	367	Gene	Gene	interactions|nmod|START_ENTITY function|nmod|interactions function|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of the androgen_receptor function by quercetin through protein-protein interactions of Sp1 , c-Jun , and the androgen_receptor in human prostate_cancer cells .
8994183	0	Sp1	136,139	androgen_receptor	87,104	Sp1	androgen receptor	6667	367	Gene	Gene	interacting|nmod|START_ENTITY role|acl|interacting role|nmod|domain domain|nmod|promoter promoter|compound|END_ENTITY	Functional role of a conformationally flexible homopurine/homopyrimidine domain of the androgen_receptor gene promoter interacting with Sp1 and a pyrimidine single strand DNA-binding protein .
12614163	0	Sp1	48,51	apolipoprotein_AI	21,38	Sp1	apolipoprotein AI	6667	335	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Insulin induction of apolipoprotein_AI , role of Sp1 .
15375792	0	Sp1	47,50	apolipoprotein_AI	17,34	Sp1	apolipoprotein AI	6667	335	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Induction of the apolipoprotein_AI promoter by Sp1 is repressed by saturated_fatty_acids .
9136080	0	Sp1	125,128	c-Myb	140,145	Sp1	c-Myb	6667	4602	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter : evidence for the role of Sp1 and not of c-Myb or PU .1 in myelomonocytic lineage-specific expression .
11479230	0	Sp1	44,47	catalase	18,26	Sp1	catalase	6667	847	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Regulation of the catalase gene promoter by Sp1 , CCAAT-recognizing factors , and a WT1/Egr-related _ factor in hydrogen_peroxide-resistant HP100 cells .
15736427	0	Sp1	0,3	cathepsin_B	14,25	Sp1	cathepsin B	20683(Tax:10090)	13030(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Sp1 regulates cathepsin_B transcription and invasiveness in murine B16 melanoma cells .
23046908	0	Sp1	46,49	cold-inducible_RNA-binding_protein	82,116	Sp1	cold-inducible RNA-binding protein	6667	1153	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible_RNA-binding_protein -LRB- cirp -RRB- expression in mammalian cells .
23201262	0	Sp1	77,80	connexin43	52,62	Sp1	connexin43	6667	2697	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Role of Rev-erba domains for transactivation of the connexin43 promoter with Sp1 .
11237594	0	Sp1	14,17	cyclin_A	32,40	Sp1	cyclin A	6667	890	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Modulation of Sp1 activity by a cyclin_A / CDK complex .
22266860	0	Sp1	0,3	cyclin_B1	49,58	Sp1	cyclin B1	6667	891	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Sp1 phosphorylation by cyclin-dependent_kinase_1 / cyclin_B1 represses its DNA-binding activity during mitosis in cancer cells .
10825178	0	Sp1	0,3	cyclooxygenase-2	28,44	Sp1	cyclooxygenase-2	6667	5743	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|endothelium endothelium|amod|END_ENTITY	Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium .
17012241	0	Sp1	59,62	cyclooxygenase-2	8,24	Sp1	cyclooxygenase-2	6667	5743	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|induction induction|amod|END_ENTITY	Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response .
18524846	0	Sp1	123,126	cyclooxygenase-2	66,82	Sp1	cyclooxygenase-2	6667	5743	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|nmod|CRMP-1 CRMP-1|nmod|inhibition inhibition|amod|END_ENTITY	Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha .
22360859	0	Sp1	0,3	cystathionine_y-lyase	33,54	Sp1	cystathionine y-lyase	6667	107869(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Sp1 is involved in regulation of cystathionine_y-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular_carcinoma cell lines .
1597451	0	Sp1	27,30	dihydrofolate_reductase	46,69	Sp1	dihydrofolate reductase	6667	1719	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	Triplex formation prevents Sp1 binding to the dihydrofolate_reductase promoter .
21504746	0	Sp1	25,28	dok-7	53,58	Sp1	dok-7	6667	285489	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|expression expression|amod|END_ENTITY	The transcription factor Sp1 plays a crucial role in dok-7 gene expression .
8923463	0	Sp1	26,29	estrogen_receptor	8,25	Sp1	estrogen receptor	6667	2099	Gene	Gene	Role|parataxis|START_ENTITY Role|nmod|END_ENTITY	Role of estrogen_receptor / Sp1 complexes in estrogen-induced heat_shock protein 27 gene expression .
9528985	0	Sp1	110,113	estrogen_receptor	92,109	Sp1	estrogen receptor	6667	2099	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Estrogen-induced c-fos protooncogene expression in MCF-7 human breast_cancer cells : role of estrogen_receptor Sp1 complex formation .
15111769	0	Sp1	62,65	estrogen_receptor_alpha	18,41	Sp1	estrogen receptor alpha	6667	2099	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|amod|END_ENTITY	Regulation of the estrogen_receptor_alpha minimal promoter by Sp1 , USF-1_and_ERalpha .
11745351	0	Sp1	0,3	fasl	17,21	Sp1	fasl	20683(Tax:10090)	14103(Tax:10090)	Gene	Gene	activator|nsubj|START_ENTITY activator|amod|END_ENTITY	Sp1 is the major fasl gene activator in abnormal CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- B220 -LRB- + -RRB- T cells of lpr and gld mice .
23860323	0	Sp1	45,48	fibrillin-1	14,25	Sp1	fibrillin-1	6667	2200	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of fibrillin-1 gene expression by Sp1 .
20607723	0	Sp1	0,3	four_and_half_lim_2	20,39	Sp1	four and half lim 2	6667	2274	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Sp1 upregulates the four_and_half_lim_2 -LRB- FHL2 -RRB- expression in gastrointestinal_cancers through transcription regulation .
1912570	0	Sp1	15,18	globin	40,46	Sp1	globin	6667	41930(Tax:7227)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Interaction of Sp1 with the human gamma globin promoter : binding and transactivation of normal and mutant promoters .
15249123	0	Sp1	66,69	glucocorticoid_receptor	20,43	Sp1	glucocorticoid receptor	6667	2908	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human glucocorticoid_receptor gene transcription by Sp1 and p53 .
17446237	0	Sp1	0,3	glucokinase	21,32	Sp1	glucokinase	6667	2645	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	Sp1 and Sp3 regulate glucokinase gene transcription in the liver of gilthead sea bream -LRB- Sparus aurata -RRB- .
22399227	0	Sp1	0,3	huntingtin	20,30	Sp1	huntingtin	6667	3064	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Sp1 regulates human huntingtin gene expression .
16035620	0	Sp1	129,132	insulin-like_growth_factor_I_receptor	27,64	Sp1	insulin-like growth factor I receptor	6667	3480	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|level level|nmod|END_ENTITY	A high expression level of insulin-like_growth_factor_I_receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric_cancer .
7491107	0	Sp1	116,119	insulin-like_growth_factor_I_receptor	14,51	Sp1	insulin-like growth factor I receptor	24790(Tax:10116)	25718(Tax:10116)	Gene	Gene	interactions|nmod|START_ENTITY Regulation|dep|interactions Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of insulin-like_growth_factor_I_receptor gene expression by Sp1 : physical and functional interactions of Sp1 at GC boxes and at a CT element .
7491107	0	Sp1	71,74	insulin-like_growth_factor_I_receptor	14,51	Sp1	insulin-like growth factor I receptor	24790(Tax:10116)	25718(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of insulin-like_growth_factor_I_receptor gene expression by Sp1 : physical and functional interactions of Sp1 at GC boxes and at a CT element .
15863387	0	Sp1	58,61	interleukin-1_alpha	6,25	Sp1	interleukin-1 alpha	6667	3552	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Human interleukin-1_alpha gene expression is regulated by Sp1 and a transcriptional repressor .
18930904	0	Sp1	113,116	lactate_dehydrogenase_c	13,36	Sp1	lactate dehydrogenase c	6667	3948	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Homo_sapiens lactate_dehydrogenase_c -LRB- Ldhc -RRB- gene expression in cancer cells is regulated by transcription factor Sp1 , CREB , and CpG island methylation .
21320120	0	Sp1	112,115	miR-1224	27,35	Sp1	miR-1224	20683(Tax:10090)	100316739(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Lipopolysaccharide-induced miR-1224 negatively regulates tumour_necrosis_factor-a gene expression by modulating Sp1 .
26832795	0	Sp1	64,67	miR-137	13,20	Sp1	miR-137	6667	406928	Gene	Gene	Protein|compound|START_ENTITY Protein|amod|END_ENTITY	Induction of miR-137 by Isorhapontigenin -LRB- ISO -RRB- Directly Targets Sp1 Protein Translation and Mediates Its Anticancer Activity Both In Vitro and In Vivo .
18440323	0	Sp1	107,110	mitotic_centromere-associated_kinesin	24,61	Sp1	mitotic centromere-associated kinesin	6667	11004	Gene	Gene	promoter|nmod|START_ENTITY promoter|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the human mitotic_centromere-associated_kinesin -LRB- MCAK -RRB- promoter by the transcription factors Sp1 and E2F1 .
11259630	0	Sp1	48,51	monoamine_oxidase_B	20,39	Sp1	monoamine oxidase B	6667	4129	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human monoamine_oxidase_B gene by Sp1 and Sp3 .
17990281	0	Sp1	34,37	mu_opioid_receptor	112,130	Sp1	mu opioid receptor	6667	4988	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|compound|END_ENTITY	The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu_opioid_receptor gene in human lymphocytes .
10457364	0	Sp1	57,60	myelin_basic_protein	14,34	Sp1	myelin basic protein	6667	4155	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Regulation of myelin_basic_protein gene transcription by Sp1 and Puralpha : evidence for association of Sp1 and Puralpha in brain .
7876196	0	Sp1	95,98	ornithine_decarboxylase	18,41	Sp1	ornithine decarboxylase	24790(Tax:10116)	24609(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|nmod|binding	Regulation of rat ornithine_decarboxylase promoter activity by binding of transcription factor Sp1 .
17689681	0	Sp1	0,3	osteopontin	14,25	Sp1	osteopontin	6667	6696	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Sp1 regulates osteopontin expression in SW480 human colon_adenocarcinoma cells .
11470525	0	Sp1	83,86	oxysterol_7_alpha-hydroxylase	36,65	Sp1	oxysterol 7 alpha-hydroxylase	6667	9420	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of human oxysterol_7_alpha-hydroxylase gene -LRB- CYP7B1 -RRB- by Sp1 .
24163379	0	Sp1	94,97	p16INK4a	38,46	Sp1	p16INK4a	6667	1029	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent_kinase_4 to transactivate microRNA-141 and microRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA damage .
10212208	0	Sp1	116,119	p21	59,62	Sp1	p21	6667	1026	Gene	Gene	sites|compound|START_ENTITY containing|dobj|sites element|acl|containing activates|nmod|element activates|dobj|promoter promoter|amod|END_ENTITY	The mycotoxin fumonisin_B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites .
10506225	0	Sp1	136,139	p21	47,50	Sp1	p21	6667	1026	Gene	Gene	superactivator|nmod|START_ENTITY acting|nmod|superactivator transactivates|advcl|acting transactivates|dobj|promoter promoter|nmod|gene gene|amod|END_ENTITY	c-Jun transactivates the promoter of the human p21 -LRB- WAF1/Cip1 -RRB- gene by acting as a superactivator of the ubiquitous transcription factor Sp1 .
10625687	0	Sp1	23,26	p21	38,41	Sp1	p21	6667	1026	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	p300 collaborates with Sp1 and Sp3 in p21 -LRB- waf1/cip1 -RRB- promoter activation induced by histone deacetylase inhibitor .
10733944	0	Sp1	74,77	p21	30,33	Sp1	p21	6667	1026	Gene	Gene	site|amod|START_ENTITY gene|nmod|site gene|nsubj|repression repression|nmod|END_ENTITY	Transcriptional repression of p21 -LRB- -LRB- Waf1/Cip1/Sdi1 -RRB- -RRB- gene by c-jun through Sp1 site .
10809237	0	Sp1	117,120	p21	56,59	Sp1	p21	6667	1026	Gene	Gene	role|nmod|START_ENTITY complex|dep|role inhibitor|parataxis|complex inhibitor|dobj|gene gene|amod|END_ENTITY	Androgen induction of cyclin-dependent kinase inhibitor p21 gene : role of androgen_receptor and transcription factor Sp1 complex .
11064455	0	Sp1	0,3	p21	21,24	Sp1	p21	6667	1026	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|gene gene|amod|END_ENTITY	Sp1 and Sp3 activate p21 -LRB- WAF1/CIP1 -RRB- gene transcription in the Caco-2 colon_adenocarcinoma cell line .
11384995	0	Sp1	0,3	p21	107,110	Sp1	p21	6667	1026	Gene	Gene	plays|nsubj|START_ENTITY plays|ccomp|inhibitor inhibitor|dobj|gene gene|amod|END_ENTITY	Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by the p53 tumor suppressor protein .
11551946	0	Sp1	51,54	p21	14,17	Sp1	p21	6667	1026	Gene	Gene	sites|amod|START_ENTITY transcription|nmod|sites WAF1/Cip1|acl|transcription WAF1/Cip1|amod|END_ENTITY	Activation of p21 -LRB- WAF1/Cip1 -RRB- transcription through Sp1 sites by histone deacetylase inhibitor apicidin : involvement of protein_kinase_C .
11842244	0	Sp1	128,131	p21	83,86	Sp1	p21	6667	1026	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	The hinge region of the human papillomavirus type 8 E2_protein activates the human p21 -LRB- WAF1/CIP1 -RRB- promoter via interaction with Sp1 .
12955081	0	Sp1	37,40	p21	14,17	Sp1	p21	6667	1026	Gene	Gene	sites|amod|START_ENTITY WAF1/Cip1|nmod|sites WAF1/Cip1|amod|END_ENTITY	Expression of p21 -LRB- WAF1/Cip1 -RRB- through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC_epsilon signaling pathway .
14744793	0	Sp1	184,187	p21	157,160	Sp1	p21	6667	1026	Gene	Gene	kinase|nmod|START_ENTITY kinase|nmod|transactivation transactivation|nmod|promoter promoter|amod|END_ENTITY	Transcriptional activation of p21 -LRB- waf1/cip1 -RRB- by alkylphospholipids : role of the mitogen-activated protein kinase pathway in the transactivation of the human p21 -LRB- waf1/cip1 -RRB- promoter by Sp1 .
15094066	0	Sp1	0,3	p21	66,69	Sp1	p21	6667	1026	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|Waf1 Waf1|amod|END_ENTITY	Sp1 is involved in the transcriptional activation of p16 -LRB- INK4 -RRB- by p21 -LRB- Waf1 -RRB- in HeLa cells .
15345676	0	Sp1	121,124	p21	73,76	Sp1	p21	6667	644914	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|activation activation|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma-dependent activation of p21 in Panc-28 pancreatic_cancer cells involves Sp1 and Sp4 proteins .
15389873	0	Sp1	117,120	p21	215,218	Sp1	p21	6667	1026	Gene	Gene	transcription|nmod|START_ENTITY muscle|acl:relcl|transcription mediated|nsubjpass|muscle mediated|nmod|promoter promoter|amod|END_ENTITY	Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21 -LRB- WAF1/Cip1 -RRB- promoter .
15389873	0	Sp1	117,120	p21	85,88	Sp1	p21	6667	1026	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|END_ENTITY	Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21 -LRB- WAF1/Cip1 -RRB- promoter .
15659839	0	Sp1	0,3	p21	73,76	Sp1	p21	6667	1026	Gene	Gene	transcription|nsubj|START_ENTITY transcription|dobj|activity activity|nmod|regulation regulation|nmod|promoters promoters|amod|END_ENTITY	Sp1 and NF-kappaB transcription factor activity in the regulation of the p21 and FasL promoters during promyelocytic_leukemia cell monocytic differentiation and its associated apoptosis .
23184467	0	Sp1	22,25	p21	106,109	Sp1	p21	6667	1026	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|advcl|modulating modulating|dobj|expression expression|nmod|END_ENTITY	Stat6 cooperates with Sp1 in controlling breast_cancer cell proliferation by modulating the expression of p21 -LRB- Cip1/WAF1 -RRB- and p27 -LRB- Kip1 -RRB- .
25595558	0	Sp1	0,3	p21	34,37	Sp1	p21	6667	644914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Sp1 regulates Raf/MEK/ERK-induced p21 -LRB- CIP1 -RRB- transcription in TP53-mutated cancer cells .
9553133	0	Sp1	102,105	p21	44,47	Sp1	p21	6667	1026	Gene	Gene	gene|nmod|START_ENTITY transcription|dep|gene transcription|nmod|cyclin cyclin|amod|END_ENTITY	Progesterone regulates transcription of the p21 -LRB- WAF1 -RRB- cyclin - dependent kinase inhibitor gene through Sp1 and CBP/p300 .
11231912	0	Sp1	8,11	p27	32,35	Sp1	p27	24790(Tax:10116)	83571(Tax:10116)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Role of Sp1 in the induction of p27 gene expression in vascular smooth muscle cells in vitro and after balloon angioplasty .
11278848	0	Sp1	107,110	p38	4,7	Sp1	p38	6667	1432	Gene	Gene	factor|amod|START_ENTITY activation|nmod|factor promoter|nmod|activation regulates|dobj|promoter regulates|nsubj|kinase kinase|amod|END_ENTITY	The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages .
16797880	0	Sp1	36,39	p38	8,11	Sp1	p38	24790(Tax:10116)	81649(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of p38 in stress activation of Sp1 .
21115498	0	Sp1	126,129	p38	91,94	Sp1	p38	24790(Tax:10116)	81649(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Heme_oxygenase-1 / carbon_monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1 .
24821721	0	Sp1	149,152	p38	190,193	Sp1	p38	6667	1432	Gene	Gene	specificity_protein_1|appos|START_ENTITY specificity_protein_1|dep|pathway pathway|amod|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
21242964	0	Sp1	46,49	p53	34,37	Sp1	p53	6667	7157	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors .
9449526	0	Sp1	14,17	p53	0,3	Sp1	p53	6667	7157	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	p53 represses Sp1 DNA binding and HIV-LTR directed transcription .
18513743	0	Sp1	69,72	p57	14,17	Sp1	p57	6667	1028	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|END_ENTITY	Regulation of p57 -LRB- KIP2 -RRB- during muscle differentiation : role of Egr1 , Sp1 and DNA hypomethylation .
11226218	0	Sp1	12,15	pRB	0,3	Sp1	pRB	6667	5925	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	pRB induces Sp1 activity by relieving inhibition mediated by MDM2 .
20150657	0	Sp1	11,14	phosphatidylethanolamine_N-methyltransferase	48,92	Sp1	phosphatidylethanolamine N-methyltransferase	20683(Tax:10090)	18618(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Sp1 in transcriptional regulation of phosphatidylethanolamine_N-methyltransferase in liver and 3T3-L1 adipocytes .
12062800	0	Sp1	66,69	prepronociceptin	41,57	Sp1	prepronociceptin	6667	5368	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of transcription of the human prepronociceptin gene by Sp1 .
11694349	0	Sp1	0,3	prolactin	20,29	Sp1	prolactin	6667	5617	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Sp1 is required for prolactin activation of the interferon_regulatory_factor-1 gene .
9175624	0	Sp1	13,16	prolactin	29,38	Sp1	prolactin	24790(Tax:10116)	24683(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T-cells : differential association of Sp1-DNA complexes with Stats .
9819401	0	Sp1	50,53	promyelocytic_leukemia_protein	4,34	Sp1	promyelocytic leukemia protein	6667	5371	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The promyelocytic_leukemia_protein interacts with Sp1 and inhibits its transactivation of the epidermal_growth_factor_receptor promoter .
18568943	0	Sp1	58,61	protein_kinase_Czeta	81,101	Sp1	protein kinase Czeta	6667	5590	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein_kinase_Czeta modulates membrane_type_1-matrix_metalloproteinase in endothelial cells .
10617653	0	Sp1	63,66	small_nuclear_RING_finger_protein	12,45	Sp1	small nuclear RING finger protein	6667	6047	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Coregulator small_nuclear_RING_finger_protein -LRB- SNURF -RRB- enhances Sp1 - and steroid receptor-mediated transcription by different mechanisms .
15013634	0	Sp1	157,160	specificity_protein_1	134,155	Sp1	specificity protein 1	6667	6667	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Transcriptional control of the human pregnancy-specific_glycoprotein_5 gene is dependent on two GT-boxes recognized by the ubiquitous specificity_protein_1 -LRB- Sp1 -RRB- transcription factor .
21465530	0	Sp1	0,3	stanniocalcin-1	36,51	Sp1	stanniocalcin-1	6667	6781	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|expression expression|amod|END_ENTITY	Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon_cancer cells , HT29 .
17449871	0	Sp1	171,174	sterol_regulatory_element-binding_protein-1c	22,66	Sp1	sterol regulatory element-binding protein-1c	24790(Tax:10116)	78968(Tax:10116)	Gene	Gene	specificity_protein_1|appos|START_ENTITY capacity|nmod|specificity_protein_1 mediated|nmod|capacity mediated|nsubjpass|Expression Expression|nmod|gene gene|amod|END_ENTITY	Expression of the rat sterol_regulatory_element-binding_protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity_protein_1 -LRB- Sp1 -RRB- .
22511764	0	Sp1	113,116	sterol_regulatory_element-binding_protein-1c	15,59	Sp1	sterol regulatory element-binding protein-1c	20683(Tax:10090)	20787(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	FoxO1 inhibits sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene expression via transcription factors Sp1 and SREBP-1c .
18698092	0	Sp1	56,59	thromboxane_A2_receptor	24,47	Sp1	thromboxane A2 receptor	6667	6915	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of the human thromboxane_A2_receptor gene by Sp1 , Egr1 , NF-E2 , GATA-1 , and Ets-1 in megakaryocytes .
21324108	0	Sp1	159,162	transforming_growth_factor_beta	14,45	Sp1	transforming growth factor beta	6667	7040	Gene	Gene	involvement|nmod|START_ENTITY Modulation|dep|involvement Modulation|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
21324108	0	Sp1	159,162	transforming_growth_factor_beta	204,235	Sp1	transforming growth factor beta	6667	7040	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
21324108	0	Sp1	159,162	transforming_growth_factor_beta	74,105	Sp1	transforming growth factor beta	6667	7040	Gene	Gene	involvement|nmod|START_ENTITY Modulation|dep|involvement Modulation|acl|signalling signalling|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
19208340	0	Sp1	99,102	transglutaminase_2	8,26	Sp1	transglutaminase 2	20683(Tax:10090)	21817(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of transglutaminase_2 in liver_injury via cross-linking and silencing of transcription factor Sp1 .
10559188	0	Sp1	2,5	tumor_necrosis_factor_alpha	26,53	Sp1	tumor necrosis factor alpha	6667	7124	Gene	Gene	site|amod|START_ENTITY site|nmod|functions functions|amod|END_ENTITY	A Sp1 binding site of the tumor_necrosis_factor_alpha promoter functions as a nitric_oxide response element .
21320120	0	Sp1	112,115	tumour_necrosis_factor-a	57,81	Sp1	tumour necrosis factor-a	20683(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Lipopolysaccharide-induced miR-1224 negatively regulates tumour_necrosis_factor-a gene expression by modulating Sp1 .
12482909	0	Sp1	10,13	vascular_endothelial_growth_factor	90,124	Sp1	vascular endothelial growth factor	6667	7422	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|dep|END_ENTITY	Increased Sp1 phosphorylation as a mechanism of hepatocyte growth factor -LRB- HGF/SF -RRB- - induced vascular_endothelial_growth_factor -LRB- VEGF/VPF -RRB- transcription .
9271438	0	Sp1	67,70	vascular_endothelial_growth_factor	82,116	Sp1	vascular endothelial growth factor	31913(Tax:7227)	32876(Tax:7227)	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The von_Hippel-Lindau_tumor_suppressor_gene product interacts with Sp1 to repress vascular_endothelial_growth_factor promoter activity .
10362515	0	Sp1/3	74,79	Btk	36,39	Sp1/3	Btk	6667;6670	695	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Synergistic activation of the human Btk promoter by transcription factors Sp1/3 and PU .1 .
11909962	0	Sp100	0,5	ETS-1	21,26	Sp100	ETS-1	6672	2113	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sp100 interacts with ETS-1 and stimulates its transcriptional activity .
15448941	0	Sp152	79,84	complement_factor_B	114,133	Sp152	complement factor B	373308(Tax:7668)	373308(Tax:7668)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152 , the sea urchin homologue of complement_factor_B .
14712480	0	Sp17	32,36	sperm_protein_17	14,30	Sp17	sperm protein 17	53340	53340	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of sperm_protein_17 -LRB- Sp17 -RRB- in ovarian_cancer .
12393185	0	Sp17-1	68,74	Sp17-2	106,112	Sp17-1	Sp17-2	53340	171424	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Genomic organization of an intron-containing sperm_protein_17 gene -LRB- Sp17-1 -RRB- and an intronless pseudogene -LRB- Sp17-2 -RRB- in humans : a new model .
12393185	0	Sp17-1	68,74	sperm_protein_17	45,61	Sp17-1	sperm protein 17	53340	53340	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of an intron-containing sperm_protein_17 gene -LRB- Sp17-1 -RRB- and an intronless pseudogene -LRB- Sp17-2 -RRB- in humans : a new model .
12393185	0	Sp17-2	106,112	Sp17-1	68,74	Sp17-2	Sp17-1	171424	53340	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Genomic organization of an intron-containing sperm_protein_17 gene -LRB- Sp17-1 -RRB- and an intronless pseudogene -LRB- Sp17-2 -RRB- in humans : a new model .
12393185	0	Sp17-2	106,112	sperm_protein_17	45,61	Sp17-2	sperm protein 17	171424	53340	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic organization of an intron-containing sperm_protein_17 gene -LRB- Sp17-1 -RRB- and an intronless pseudogene -LRB- Sp17-2 -RRB- in humans : a new model .
24623314	0	Sp2	69,72	miR-638	0,7	Sp2	miR-638	6668	693223	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	miR-638 suppresses cell proliferation in gastric_cancer by targeting Sp2 .
19482358	0	Sp2	0,3	socs1	40,45	Sp2	socs1	6668	8651	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Sp2 regulates interferon-gamma-mediated socs1 gene expression .
16732318	0	Sp3	74,77	BAK	16,19	Sp3	BAK	6670	578	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding .
26012884	0	Sp3	39,42	BNIP3	30,35	Sp3	BNIP3	6670	664	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of BNIP3 by Sp3 in prostate_cancer .
15362956	0	Sp3	81,84	DNA_methyltransferase_3A	40,64	Sp3	DNA methyltransferase 3A	6670	1788	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of the human DNA_methyltransferase_3A and 3B genes by Sp3 and Sp1 zinc finger proteins .
25068794	0	Sp3	78,81	Histone_deacetylase_4	0,21	Sp3	Histone deacetylase 4	6670	9759	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Histone_deacetylase_4 promotes ubiquitin-dependent proteasomal degradation of Sp3 in SH-SY5Y cells treated with di -LRB- 2-ethylhexyl -RRB- phthalate -LRB- DEHP -RRB- , determining neuronal_death .
12954773	0	Sp3	55,58	Sp1	85,88	Sp3	Sp1	6670	6667	Gene	Gene	efficiently|compound|START_ENTITY competes|nsubj|efficiently competes|nmod|END_ENTITY	Stability of the Sp3-DNA complex is promoter-specific : Sp3 efficiently competes with Sp1 for binding to promoters containing multiple Sp-sites .
26352013	0	Sp3	20,23	Sp1	0,3	Sp3	Sp1	6670	6667	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Sp1 cooperates with Sp3 to upregulate MALAT1 expression in human hepatocellular_carcinoma .
26967243	0	Sp3	52,55	Sp1	47,50	Sp3	Sp1	6670	6667	Gene	Gene	genes|nsubj|START_ENTITY genes|ccomp|transcription transcription|dobj|END_ENTITY	Specificity protein -LRB- Sp -RRB- transcription factors Sp1 , Sp3 and Sp4 are non-oncogene addiction genes in cancer cells .
8845379	0	Sp3	83,86	Sp1	0,3	Sp3	Sp1	31917(Tax:7227)	31913(Tax:7227)	Gene	Gene	repressed|nmod|START_ENTITY repressed|nsubj|trans-activation trans-activation|amod|END_ENTITY	Sp1 trans-activation of cell cycle regulated promoters is selectively repressed by Sp3 .
9006959	1	Sp3	66,69	Sp1	61,64	Sp3	Sp1	6670	6667	Gene	Gene	factors|amod|START_ENTITY necessary|nsubj|factors necessary|advmod|END_ENTITY	Sp1 , Sp3 , TTF-1 , and HNF-3alpha transcription factors are necessary for lung cell-specific activation of SP-B gene transcription .
9115370	0	Sp3	21,24	Sp1	91,94	Sp3	Sp1	367846(Tax:10116)	24790(Tax:10116)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	Transcription factor Sp3 antagonizes activation of the ornithine_decarboxylase promoter by Sp1 .
9867805	0	Sp3	0,3	Sp1	56,59	Sp3	Sp1	6670	6667	Gene	Gene	repress|nsubj|START_ENTITY repress|advcl|competing competing|nmod|END_ENTITY	Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter .
12176973	0	Sp3	30,33	histone_deacetylase_2	72,93	Sp3	histone deacetylase 2	6670	3066	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone_deacetylase_2 .
17059557	0	Sp3	51,54	neurotrophin-3	14,28	Sp3	neurotrophin-3	6670	4908	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of neurotrophin-3 gene transcription by Sp3 and Sp4 in neurons .
23000412	0	Sp3	74,77	trefoil_factor_2	18,34	Sp3	trefoil factor 2	6670	7032	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	The regulation of trefoil_factor_2 expression by the transcription factor Sp3 .
25045015	0	Sp4	21,24	nervous_wreck_2	49,64	Sp4	nervous wreck 2	6671	89848	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Transcription factor Sp4 regulates expression of nervous_wreck_2 to control NMDAR1 levels and dendrite patterning .
23886710	0	Sp7	59,62	miR-145	0,7	Sp7	miR-145	170574(Tax:10090)	387163(Tax:10090)	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	miR-145 suppresses osteogenic differentiation by targeting Sp7 .
15358670	0	Sp8	0,3	Fgf8	81,85	Sp8	Fgf8	776034(Tax:9031)	396313(Tax:9031)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Sp8 and Sp9 , two closely related buttonhead-like transcription factors , regulate Fgf8 expression and limb outgrowth in vertebrate embryos .
23967141	0	Sp8_transcription_factor	36,60	SP8	67,70	Sp8 transcription factor	SP8	221833	221833	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants on 3q21 and in the Sp8_transcription_factor gene -LRB- SP8 -RRB- as susceptibility loci for psychotic_disorders : a genetic association study .
15085313	0	Sp_1	48,52	R1_and_Puv_II	85,98	Sp 1	R1 and Puv II	6667	910	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	The relationship between COLI A1 polymorphisms -LRB- Sp_1 -RRB- and COLI A2 polymorphisms -LRB- Eco R1_and_Puv_II -RRB- with bone_mineral_density in Chinese men and women .
18813851	0	Spa-1	30,35	Rap1	86,90	Spa-1	Rap1	6494	5906	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Bcr/Abl P190 interaction with Spa-1 , a GTPase activating protein for the small GTPase Rap1 .
16325503	0	Spa2	53,57	Cdc24	130,135	Spa2	Cdc24	850639(Tax:4932)	851190(Tax:4932)	Gene	Gene	localization|nmod|START_ENTITY independent|nsubj|localization independent|nmod|END_ENTITY	Cdc42-dependent localization of polarisome component Spa2 to the incipient bud site is independent of the GDP/GTP exchange factor Cdc24 .
10373309	0	Spag4	0,5	Odf1	62,66	Spag4	Odf1	6676	4956	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Spag4 , a novel sperm protein , binds outer dense-fiber protein Odf1 and localizes to microtubules of manchette and axoneme .
15175239	0	Spam1	0,5	PH-20	7,12	Spam1	PH-20	20690(Tax:10090)	20690(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Spam1 -LRB- PH-20 -RRB- expression in the extratesticular duct and accessory organs of the mouse : a possible role in sperm fluid reabsorption .
20504295	0	Spartin	0,7	E3_ubiquitin_ligase	58,77	Spartin	E3 ubiquitin ligase	23111	158506	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Spartin activates atrophin-1-interacting_protein_4 -LRB- AIP4 -RRB- E3_ubiquitin_ligase and promotes ubiquitination of adipophilin on lipid droplets .
9858857	0	Spasmolysin	31,42	TFF2	25,29	Spasmolysin	TFF2	7032	7032	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Variable distribution of TFF2 -LRB- Spasmolysin -RRB- alleles in Europeans does not indicate predisposition to gastric_cancer .
15269182	0	Spastin	0,7	NA14	47,51	Spastin	NA14	6683	8636	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Spastin interacts with the centrosomal protein NA14 , and is enriched in the spindle pole , the midbody and the distal axon .
12552568	0	Spastin	100,107	SPG4	94,98	Spastin	SPG4	6683	6683	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Screening of patients with hereditary_spastic_paraplegia reveals seven novel mutations in the SPG4 -LRB- Spastin -RRB- gene .
21445983	0	Spata4	0,6	Runx2	65,70	Spata4	Runx2	69281(Tax:10090)	12393(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|pathway pathway|amod|END_ENTITY	Spata4 promotes osteoblast differentiation through Erk-activated Runx2 pathway .
12771232	0	Spata6	108,114	spermatogenesis_associated_6	73,101	Spata6	spermatogenesis associated 6	67946(Tax:10090)	67946(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization , expression pattern and chromosomal localization of the spermatogenesis_associated_6 gene -LRB- Spata6 -RRB- .
17196196	0	Spatial	24,31	KIF17b	98,104	Spatial	KIF17b	65971(Tax:10090)	16559(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Dynamic distribution of Spatial during mouse spermatogenesis and its interaction with the kinesin KIF17b .
19918778	0	Spatial	0,7	Tbata	9,14	Spatial	Tbata	65971(Tax:10090)	65971(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Spatial -LRB- Tbata -RRB- expression in mature medullary thymic_epithelial_cells .
11278681	0	Spc110p	54,61	Mps1p	6,11	Spc110p	Mps1p	851957(Tax:4932)	851533(Tax:4932)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain .
9384578	0	Spc110p	121,128	Spc98p	0,6	Spc110p	Spc98p	851957(Tax:4932)	855597(Tax:4932)	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p .
8886974	0	Spc110p	19,26	calmodulin	35,45	Spc110p	calmodulin	851957(Tax:4932)	852406(Tax:4932)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The spacer protein Spc110p targets calmodulin to the central plaque of the yeast spindle pole body .
9148931	0	Spc3p	27,32	SPC22/23	10,18	Spc3p	SPC22/23	850755(Tax:4932)	7554741(Tax:476213)	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity .
11827982	0	Spc42p	100,106	Mps1p	25,30	Spc42p	Mps1p	853824(Tax:4932)	851533(Tax:4932)	Gene	Gene	assembly|nmod|START_ENTITY required|nmod|assembly required|nsubjpass|END_ENTITY	The yeast protein kinase Mps1p is required for assembly of the integral spindle pole body component Spc42p .
9606209	0	Spc72p	38,44	Stu2p	60,65	Spc72p	Stu2p	851250(Tax:4932)	850734(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The yeast spindle pole body component Spc72p interacts with Stu2p and is required for proper microtubule assembly .
9384578	0	Spc98p	0,6	Spc110p	121,128	Spc98p	Spc110p	855597(Tax:4932)	851957(Tax:4932)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	Spc98p and Spc97p of the yeast gamma-tubulin complex mediate binding to the spindle pole body via their interaction with Spc110p .
8670895	0	Spc98p	32,38	Tub4p	77,82	Spc98p	Tub4p	855597(Tax:4932)	850909(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces_cerevisiae at the sites of microtubule attachment .
21659522	0	Specificity_protein-1	0,21	cystathionine_gamma-lyase	55,80	Specificity protein-1	cystathionine gamma-lyase	6667	1491	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Specificity_protein-1 as a critical regulator of human cystathionine_gamma-lyase in smooth muscle cells .
24801450	0	Specificity_protein_1	0,21	topoisomerase_IIb	32,49	Specificity protein 1	topoisomerase IIb	6667	7155	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Specificity_protein_1 regulates topoisomerase_IIb expression in SH-SY5Y cells during neuronal differentiation .
17567933	0	Specificity_protein_1	0,21	transforming_growth_factor-beta1	86,118	Specificity protein 1	transforming growth factor-beta1	6667	7040	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Specificity_protein_1 and Smad-dependent regulation of human heme_oxygenase-1 gene by transforming_growth_factor-beta1 in renal epithelial cells .
16129689	0	Spen	72,76	EB2	57,60	Spen	EB2	23013	10982	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Interaction of the Epstein-Barr_virus mRNA export factor EB2 with human Spen proteins SHARP , OTT1 , and a novel member of the family , OTT3 , links Spen proteins with splicing regulation and mRNA export .
20946629	0	Spermine_oxidase	0,16	SMO	18,21	Spermine oxidase	SMO	54498	54498	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Spermine_oxidase -LRB- SMO -RRB- activity in breast_tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm .
27099350	0	SphK1	13,18	Egr-1	34,39	SphK1	Egr-1	8877	1958	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	PDGF Induces SphK1 Expression via Egr-1 to Promote Pulmonary Artery Smooth Muscle Cell Proliferation .
25811928	0	Sphingomyelin_Phosphodiesterase_1	82,115	SMPD1	117,122	Sphingomyelin Phosphodiesterase 1	SMPD1	6609	6609	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Four Novel p.N385K , p.V36A , c.1033-1034insT and c.1417-1418delCT Mutations in the Sphingomyelin_Phosphodiesterase_1 -LRB- SMPD1 -RRB- Gene in Patients with Types A and B Niemann-Pick_Disease -LRB- NPD -RRB- .
25492490	0	Sphingosine-1-Phosphate_Receptor_1	25,59	Receptor_Activator_of_Nuclear_Factor_Kappa_B_Ligand	65,116	Sphingosine-1-Phosphate Receptor 1	Receptor Activator of Nuclear Factor Kappa B Ligand	29733(Tax:10116)	117516(Tax:10116)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Different Correlation of Sphingosine-1-Phosphate_Receptor_1 with Receptor_Activator_of_Nuclear_Factor_Kappa_B_Ligand and Regulatory T Cells in Rat Periapical Lesions .
26208383	0	Sphingosine-1-Phosphate_Receptor_3	109,143	Akt	83,86	Sphingosine-1-Phosphate Receptor 3	Akt	1903	207	Gene	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate_Receptor_3 / Platelet-Derived_Growth_Factor_Receptor-b .
14592418	0	Sphingosine-1-phosphate	0,23	GPR6	85,89	Sphingosine-1-phosphate	GPR6	13609(Tax:10090)	140741(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2 + release by activating the sphingosine-kinase pathway .
19091959	0	Sphingosine-1-phosphate	0,23	MAP_kinase_phosphatase-3	105,129	Sphingosine-1-phosphate	MAP kinase phosphatase-3	13609(Tax:10090)	67603(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|induction induction|nmod|END_ENTITY	Sphingosine-1-phosphate inhibits high glucose-mediated ERK1/2 action in endothelium through induction of MAP_kinase_phosphatase-3 .
19608972	0	Sphingosine-1-phosphate_receptor-2	0,34	smooth_muscle_alpha-actin	59,84	Sphingosine-1-phosphate receptor-2	smooth muscle alpha-actin	14739(Tax:10090)	20589(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Sphingosine-1-phosphate_receptor-2 regulates expression of smooth_muscle_alpha-actin after arterial_injury .
26238015	0	Sphingosine-1-phosphate_receptor_1	0,34	S1PR1	36,41	Sphingosine-1-phosphate receptor 1	S1PR1	1901	1901	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sphingosine-1-phosphate_receptor_1 -LRB- S1PR1 -RRB- expression in non-muscle_invasive_urothelial_carcinoma : Association with poor clinical outcome and potential therapeutic target .
20416181	0	Sphingosine_1-phosphate_receptor_1	22,56	CD4	71,74	Sphingosine 1-phosphate receptor 1	CD4	1901	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|T T|compound|END_ENTITY	-LSB- Impact of rhG-CSF on Sphingosine_1-phosphate_receptor_1 expression in CD4 + T cells of donor peripheral blood -RSB- .
11777919	0	Sphingosine_kinase	0,18	tumor_necrosis_factor-alpha	53,80	Sphingosine kinase	tumor necrosis factor-alpha	8877	7124	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sphingosine_kinase interacts with TRAF2 and dissects tumor_necrosis_factor-alpha signaling .
15632208	0	Sphingosine_kinase-1	0,20	Akt	104,107	Sphingosine kinase-1	Akt	8877	207	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	Sphingosine_kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K / Akt and regulation of Bcl-2 family members .
17064696	0	Sphingosine_kinase-1	0,20	cathepsin_B	35,46	Sphingosine kinase-1	cathepsin B	8877	1508	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Sphingosine_kinase-1 is cleaved by cathepsin_B in vitro : identification of the initial cleavage sites for the protease .
18424450	0	Sphingosine_kinase_1	0,20	S1P	21,24	Sphingosine kinase 1	S1P	20698(Tax:10090)	13609(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|axis axis|compound|END_ENTITY	Sphingosine_kinase_1 / S1P receptor signaling axis controls glial proliferation in mice with Sandhoff_disease .
26937138	0	Sphingosine_kinase_1	0,20	lysophosphatidic_acid_receptor_2	41,73	Sphingosine kinase 1	lysophosphatidic acid receptor 2	8877	9170	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Sphingosine_kinase_1 is upregulated with lysophosphatidic_acid_receptor_2 in human colorectal_cancer .
23766515	0	Sphingosine_kinase_1	0,20	peroxisome_proliferator-activated_receptor	37,79	Sphingosine kinase 1	peroxisome proliferator-activated receptor	20698(Tax:10090)	19013(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Sphingosine_kinase_1 is regulated by peroxisome_proliferator-activated_receptor a in response to free fatty_acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity .
9785760	0	Spi-2	75,80	serine_proteinase_inhibitor_2	44,73	Spi-2	serine proteinase inhibitor 2	24794(Tax:10116)	24794(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	One Lewis rat with homozygous defect of the serine_proteinase_inhibitor_2 -LRB- Spi-2 -RRB- gene and two Lewis rats with heterozygous Spi-2 gene defect .
16861304	0	Spi-B	15,20	OBF-1	68,73	OCA-B	OBF-1	18985(Tax:10090)	18985(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The Ets factor Spi-B is a direct critical target of the coactivator OBF-1 .
11672537	0	Spi-B	5,10	c-rel	25,30	Spi-B	c-rel	272382(Tax:10090)	19696(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	PU .1 / Spi-B regulation of c-rel is essential for mature B cell survival .
18386042	0	Spink3	62,68	serine_protease_inhibitor_kazal_type_3	22,60	Spink3	serine protease inhibitor kazal type 3	20730(Tax:10090)	20730(Tax:10090)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of serine_protease_inhibitor_kazal_type_3 -LRB- Spink3 -RRB- during mouse embryonic development .
26138128	0	Spleen_Tyrosine_Kinase	35,57	Macrophage-Inducible_C-Type_Lectin	0,34	Spleen Tyrosine Kinase	Macrophage-Inducible C-Type Lectin	25155(Tax:10116)	450223(Tax:10116)	Gene	Gene	Contributes|compound|START_ENTITY END_ENTITY|dep|Contributes	Macrophage-Inducible_C-Type_Lectin / Spleen_Tyrosine_Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats .
26138128	0	Spleen_Tyrosine_Kinase	35,57	Macrophage-Inducible_C-Type_Lectin	0,34	Spleen Tyrosine Kinase	Macrophage-Inducible C-Type Lectin	25155(Tax:10116)	450223(Tax:10116)	Gene	Gene	Contributes|compound|START_ENTITY END_ENTITY|dep|Contributes	Macrophage-Inducible_C-Type_Lectin / Spleen_Tyrosine_Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats .
26381330	0	Spleen_Tyrosine_Kinase	18,40	Syk	42,45	Spleen Tyrosine Kinase	Syk	6850	6850	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Imidazotriazines : Spleen_Tyrosine_Kinase -LRB- Syk -RRB- Inhibitors Identified by Free-Energy Perturbation -LRB- FEP -RRB- .
21576362	0	Spn1	0,4	Toll	35,39	Spn1	Toll	49808(Tax:7227)	43222(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Spn1 regulates the GNBP3-dependent Toll signaling pathway in Drosophila_melanogaster .
15527779	0	Spn4A	30,35	furin	14,19	Spn4A	furin	49805(Tax:7227)	47220(Tax:7227)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of furin by serpin Spn4A from Drosophila_melanogaster .
24967584	0	Spns1	139,144	p53	121,124	Spns1	p53	799873(Tax:7955)	2768677(Tax:7227)	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Aberrant autolysosomal regulation is linked to the induction of embryonic senescence : differential roles of Beclin_1 and p53 in vertebrate Spns1 deficiency .
26032498	0	Spondin_1	0,9	Fak	50,53	Spondin 1	Fak	10418	5747	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Spondin_1 promotes metastatic progression through Fak and Src dependent pathway in human osteosarcoma .
22046352	0	Spp1	33,37	Sox9	0,4	Spp1	Sox9	20750(Tax:10090)	20682(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes .
26334966	0	Spp24	33,38	BMP-2	99,104	Spp24	BMP-2	6694	650	Gene	Gene	kD|appos|START_ENTITY inhibits|nsubj|kD inhibits|dobj|growth growth|nmod|cells cells|acl|caused caused|nmod|END_ENTITY	Secreted phosphoprotein 24 kD -LRB- Spp24 -RRB- inhibits growth of human pancreatic_cancer cells caused by BMP-2 .
21616146	0	Spred1	63,69	FGFRL1	28,34	Spred1	FGFRL1	161742	53834	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the receptor FGFRL1 with the negative regulator Spred1 .
21668589	0	Spred1	96,102	miR126	0,6	Spred1	miR126	114715(Tax:10090)	387145(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1 .
19822672	0	Spred2	0,6	NBR1	51,55	Spred2	NBR1	200734	4077	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling .
22619325	0	Sprn	41,45	prion_protein	16,29	Sprn	prion protein	212518(Tax:10090)	19122(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Knockout of the prion_protein -LRB- PrP -RRB- - like Sprn gene does not produce embryonic_lethality in combination with PrP -LRB- C -RRB- - deficiency .
17369402	0	Sprouty-2	0,9	K-ras	30,35	Sprouty-2	K-ras	10253	3845	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis .
19690147	0	Sprouty2	0,8	B-Raf	26,31	Sprouty2	B-Raf	10253	673	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation .
20136656	0	Sprouty2	26,34	CrkL	0,4	Sprouty2	CrkL	24064(Tax:10090)	12929(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling .
17320394	0	Sprouty2	40,48	EGFR	22,26	Sprouty2	EGFR	10253	1956	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Spatial regulation of EGFR signaling by Sprouty2 .
19896936	0	Sprouty2	64,72	Fgf8	33,37	Sprouty2	Fgf8	395584(Tax:9031)	396313(Tax:9031)	Gene	Gene	pathway|nmod|START_ENTITY pathway|nmod|END_ENTITY	Activation of Ras-ERK pathway by Fgf8 and its downregulation by Sprouty2 for the isthmus organizing activity .
17689925	0	Sprouty2	0,8	Grb2	15,19	Sprouty2	Grb2	10253	2885	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Sprouty2 binds Grb2 at two different proline-rich regions , and the mechanism of ERK inhibition is independent of this interaction .
12717443	0	Sprouty4	10,18	ERK	46,49	Sprouty4	ERK	81848	5594	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1 .
21543492	0	Sprouty_2	0,9	Eap20	32,37	Sprouty 2	Eap20	10253	84313	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Sprouty_2 binds ESCRT-II factor Eap20 and facilitates HIV-1 gag release .
18485666	0	Sprouty_2	0,9	FGFR3	19,24	Sprouty 2	FGFR3	10253	2261	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	Sprouty_2 disturbs FGFR3 degradation in thanatophoric_dysplasia_type_II : a severe form of human achondroplasia .
22024412	0	Sprr1a	114,120	Sox11	25,30	Sprr1a	Sox11	20753(Tax:10090)	20666(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a .
26230950	0	Spry1	88,93	FGF13	0,5	Spry1	FGF13	24063(Tax:10090)	14168(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	FGF13 regulates proliferation and differentiation of skeletal muscle by down-regulating Spry1 .
21134562	0	Spry2	0,5	BRAF	33,37	Spry2	BRAF	10253	673	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|mutation mutation|compound|END_ENTITY	Spry2 expression correlates with BRAF mutation in thyroid_cancer .
25663918	0	Spry2	22,27	MicroRNA-27b	0,12	Spry2	MicroRNA-27b	10253	407019	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MicroRNA-27b inhibits Spry2 expression and promotes cell invasion in glioma U251 cells .
18406329	0	Spt16	108,113	H2AX	42,46	Spt16	H2AX	11198	3014	Gene	Gene	phosphorylation|nmod|START_ENTITY regulated|nmod|phosphorylation regulated|nsubj|exchange exchange|nmod|END_ENTITY	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16 .
18406329	0	Spt16	108,113	H2AX	79,83	Spt16	H2AX	11198	3014	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16 .
22973055	0	Spt5	21,25	Sub1	0,4	Spt5	Sub1	854999(Tax:4932)	855055(Tax:4932)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Sub1 associates with Spt5 and influences RNA polymerase II transcription elongation rate .
25869138	0	Spy1	0,4	SCG10	49,54	Spy1	SCG10	245711	11075	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Spy1 mediates phosphorylation and degradation of SCG10 in axonal_degeneration .
12972555	0	Spy1	0,4	p27Kip1	20,27	Spy1	p27Kip1	245711	1027	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Spy1 interacts with p27Kip1 to allow G1/S progression .
15226296	0	Spz1	48,52	PP1	90,93	Spz1	PP1	79401(Tax:10090)	19047(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
15226296	0	Spz1	48,52	phosphatase-1	75,88	Spz1	phosphatase-1	79401(Tax:10090)	19047(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
15226296	0	Spz1	48,52	spermatogenic_zip_protein	22,47	Spz1	spermatogenic zip protein	79401(Tax:10090)	79401(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
15123463	0	Squamous_cell_carcinoma_related_oncogene	0,40	vascular_endothelial_growth_factor-A	72,108	Squamous cell carcinoma related oncogene	vascular endothelial growth factor-A	54165	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Squamous_cell_carcinoma_related_oncogene regulates angiogenesis through vascular_endothelial_growth_factor-A .
15269173	0	Sra-1	0,5	Kette	21,26	Sra-1	Kette	41861(Tax:7227)	40462(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila .
16260607	0	Sra-1	59,64	WAVE1	65,70	Sra-1	WAVE1	23191	8936	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1 / WAVE1 complex and axon formation .
11118219	0	Srb7p	0,5	Tup1p	48,53	Srb7p	Tup1p	851903(Tax:4932)	850445(Tax:4932)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Srb7p is a physical and physiological target of Tup1p .
12869565	0	Src	0,3	AKT	105,108	Src	AKT	20779(Tax:10090)	11651(Tax:10090)	Gene	Gene	kinases|compound|START_ENTITY alter|nsubj|kinases alter|xcomp|regulate regulate|dobj|cascades cascades|compound|END_ENTITY	Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol_3-kinase / AKT cascades .
23338526	0	Src	18,21	AKT	76,79	Src	AKT	6714	207	Gene	Gene	Downregulation|nmod|START_ENTITY enhances|nsubj|Downregulation enhances|nmod|END_ENTITY	Downregulation of Src enhances the cytotoxic effect of temozolomide through AKT in glioma .
10829062	0	Src	21,24	Abl	53,56	Src	Abl	6714	25	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|suppressor suppressor|nmod|kinase kinase|compound|END_ENTITY	The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation .
16441434	0	Src	22,25	Abl	0,3	Src	Abl	6714	25	Gene	Gene	kinases|compound|START_ENTITY collaborates|nmod|kinases collaborates|nsubj|END_ENTITY	Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia_virus .
18338755	0	Src	37,40	Abl	61,64	Src	Abl	6714	25	Gene	Gene	CGP76030|compound|START_ENTITY using|dobj|CGP76030 Overcoming|advcl|using variants|advcl|Overcoming variants|nsubj|nilotinib nilotinib|compound|END_ENTITY	Overcoming imatinib resistance using Src inhibitor CGP76030 , Abl inhibitor nilotinib and Abl/Lyn inhibitor INNO-406 in newly established K562 variants with BCR-ABL gene amplification .
20451394	0	Src	5,8	Abl	45,48	Src	Abl	6714	25	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	Dual Src and Abl inhibitors target wild type Abl and the AblT315I Imatinib-resistant mutant with different mechanisms .
21301049	0	Src	0,3	Abl	14,17	Src	Abl	20779(Tax:10090)	11350(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Src activates Abl to augment Robo1 expression in order to promote tumor cell migration .
8643668	0	Src	31,34	Abl	69,72	Src	Abl	6714	25	Gene	Gene	preferences|nmod|START_ENTITY homology|nsubj|preferences homology|nmod|Crk Crk|appos|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
8643668	0	Src	59,62	Abl	69,72	Src	Abl	6714	25	Gene	Gene	Crk|compound|START_ENTITY Crk|appos|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
12600984	0	Src	20,23	Akt	83,86	Src	Akt	6714	207	Gene	Gene	Interaction|nmod|START_ENTITY required|nsubjpass|Interaction required|nmod|activation activation|compound|END_ENTITY	Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation .
16669788	0	Src	24,27	Akt	78,81	Src	Akt	83805(Tax:10116)	24185(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY regulates|nsubj|activation regulates|dobj|apoptosis apoptosis|nmod|cells cells|nmod|END_ENTITY	Integrin_beta3-mediated Src activation regulates apoptosis in IEC-6 cells via Akt and STAT3 .
25338626	0	Src	53,56	Akt	94,97	Src	Akt	20779(Tax:10090)	11651(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY species|dep|activation species|dep|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|dep|bortezomib bortezomib|compound|END_ENTITY	Reactive oxygen species - mediated activation of the Src - epidermal_growth_factor_receptor - Akt signaling cascade prevents bortezomib - induced apoptosis in hepatocellular_carcinoma cells .
25725285	0	Src	31,34	Akt	55,58	Src	Akt	6714	207	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Cytoskeletal rearrangement and Src and PI-3K-dependent Akt activation control GABABR-mediated chemotaxis .
25730905	0	Src	86,89	Androgen_receptor	0,17	Src	Androgen receptor	6714	367	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|regulation regulation|amod|END_ENTITY	Androgen_receptor non-nuclear regulation of prostate_cancer cell invasion mediated by Src and matriptase .
11882594	0	Src	34,37	C-terminal_Src_kinase	130,151	Src	C-terminal Src kinase	83805(Tax:10116)	315707(Tax:10116)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|activity activity|amod|END_ENTITY	Increased angiotensin_II-mediated Src signaling via epidermal_growth_factor_receptor transactivation is associated with decreased C-terminal_Src_kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats .
12746317	0	Src	85,88	CSK	23,26	Src	CSK	20779(Tax:10090)	12988(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY factor-I|acl|signaling modulates|dobj|factor-I modulates|nsubj|C-terminal_Src_kinase C-terminal_Src_kinase|appos|END_ENTITY	C-terminal_Src_kinase -LRB- CSK -RRB- modulates insulin-like growth factor-I signaling through Src in 3T3-L1 differentiation .
24632723	0	Src	40,43	CSK	83,86	Src	CSK	6714	1445	Gene	Gene	activity|compound|START_ENTITY activity|nmod|inhibition inhibition|nmod|END_ENTITY	SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes .
7678701	0	Src	19,22	CSK	109,112	Src	CSK	83805(Tax:10116)	315707(Tax:10116)	Gene	Gene	mutants|compound|START_ENTITY Phosphorylation|nmod|mutants correlate|nsubj|Phosphorylation correlate|nmod|END_ENTITY	Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK .
21220330	0	Src	50,53	CUB-domain-containing_protein_1	0,31	Src	CUB-domain-containing protein 1	6714	64866	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	CUB-domain-containing_protein_1 -LRB- CDCP1 -RRB- activates Src to promote melanoma metastasis .
10204582	0	Src	28,31	Cbl	0,3	Src	Cbl	6714	867	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	Cbl functions downstream of Src kinases in Fc_gamma_RI signaling in primary human macrophages .
15280426	0	Src	46,49	Cdk5	0,4	Src	Cdk5	20779(Tax:10090)	12568(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Cdk5 regulates activation and localization of Src during corneal epithelial wound closure .
21442427	0	Src	20,23	Cdk5	0,4	Src	Cdk5	6714	1020	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Cdk5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src -LRB- S75 -RRB- .
25077552	0	Src	0,3	Cortactin	74,83	Src	Cortactin	6714	2017	Gene	Gene	START_ENTITY|dobj|Recycling Recycling|nmod|Phosphorylation Phosphorylation|compound|END_ENTITY	Src Regulates Sequence-Dependent Beta-2_Adrenergic_Receptor Recycling via Cortactin Phosphorylation .
8643668	0	Src	31,34	Cortactin	74,83	Src	Cortactin	6714	2017	Gene	Gene	preferences|nmod|START_ENTITY homology|nsubj|preferences homology|nmod|Crk Crk|appos|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
8643668	0	Src	59,62	Cortactin	74,83	Src	Cortactin	6714	2017	Gene	Gene	Crk|compound|START_ENTITY Crk|appos|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
16002086	0	Src	61,64	Csk	49,52	Src	Csk	6714	1445	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation .
16678999	0	Src	61,64	Csk	126,129	Src	Csk	6714	1445	Gene	Gene	regulation|nmod|START_ENTITY kinase|nsubj|regulation kinase|nmod|END_ENTITY	Negative regulation of protease-activated_receptor_1-induced Src kinase activity by the association of phosphocaveolin-1 with Csk .
17192274	0	Src	83,86	Csk	68,71	Src	Csk	6714	1445	Gene	Gene	leading|xcomp|START_ENTITY promotes|dep|leading promotes|nmod|down-regulation down-regulation|nmod|END_ENTITY	PRL3 promotes cell invasion and proliferation by down-regulation of Csk leading to Src activation .
7518562	0	Src	19,22	Csk	0,3	Src	Csk	20779(Tax:10090)	12988(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7518562	0	Src	19,22	Csk	44,47	Src	Csk	20779(Tax:10090)	12988(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY involves|nsubj|suppression involves|dobj|movement movement|nmod|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7518562	0	Src	60,63	Csk	0,3	Src	Csk	20779(Tax:10090)	12988(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY sites|nmod|activity involves|nmod|sites involves|nsubj|suppression suppression|compound|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7518562	0	Src	60,63	Csk	44,47	Src	Csk	20779(Tax:10090)	12988(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY sites|nmod|activity involves|nmod|sites involves|dobj|movement movement|nmod|END_ENTITY	Csk suppression of Src involves movement of Csk to sites of Src activity .
7529760	0	Src	14,17	Csk	103,106	Src	Csk	83805(Tax:10116)	315707(Tax:10116)	Gene	Gene	kinases|compound|START_ENTITY Regulation|nmod|kinases Regulation|dep|correlation correlation|nmod|kinase kinase|appos|END_ENTITY	Regulation of Src family kinases in the developing rat brain : correlation with their regulator kinase , Csk .
8979366	0	Src	98,101	Csk	27,30	Src	Csk	6714	1445	Gene	Gene	contain|dobj|START_ENTITY cells|acl:relcl|contain active|nmod|cells expressed|xcomp|active expressed|nsubjpass|C-terminal_Src_kinase C-terminal_Src_kinase|appos|END_ENTITY	The C-terminal_Src_kinase -LRB- Csk -RRB- is widely expressed , active in HT-29 cells that contain activated Src , and its expression is downregulated in butyrate-treated SW620 cells .
9794236	0	Src	23,26	Csk	64,67	Src	Csk	6714	1445	Gene	Gene	Autophosphorylation|nmod|START_ENTITY blocks|nsubj|Autophosphorylation blocks|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation .
25980494	0	Src	21,24	Cyr61	0,5	Src	Cyr61	6714	3491	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	Cyr61 as mediator of Src signaling in triple negative breast cancer cells .
17803936	0	Src	71,74	DAPK	21,25	Src	DAPK	6714	1612	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR .
17700527	0	Src	47,50	Diacylglycerol_kinase-alpha	0,27	Src	Diacylglycerol kinase-alpha	6714	1606	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Diacylglycerol_kinase-alpha phosphorylation by Src on Y335 is required for activation , membrane recruitment and Hgf-induced cell motility .
11884411	0	Src	43,46	Discoidin_domain_receptor_2	0,27	Src	Discoidin domain receptor 2	6714	4921	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Discoidin_domain_receptor_2 interacts with Src and Shc following its activation by type I collagen .
26858977	0	Src	32,35	Dsg3	13,17	Src	Dsg3	6714	1830	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1 .
11726541	0	Src	33,36	EDG-1	0,5	Src	EDG-1	6714	1901	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration .
23532252	0	Src	14,17	EGF	32,35	Src	EGF	6714	1950	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	PTPa-mediated Src activation by EGF in human breast_cancer cells .
26773066	0	Src	6,9	EGFR	12,16	Src	EGFR	83805(Tax:10116)	24329(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|Signaling Signaling|compound|END_ENTITY	Csk / Src / EGFR Signaling regulates migration of myofibroblasts and alveolarization .
17991704	0	Src	58,61	Epidermal_growth_factor	0,23	Src	Epidermal growth factor	20779(Tax:10090)	13645(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration .
16407214	0	Src	71,74	Epidermal_growth_factor_receptor	0,32	Src	Epidermal growth factor receptor	6714	1956	Gene	Gene	trafficking|amod|START_ENTITY exposed|nmod|trafficking exposed|nsubj|END_ENTITY	Epidermal_growth_factor_receptor exposed to oxidative stress undergoes Src - and caveolin-1-dependent perinuclear trafficking .
25359883	0	Src	14,17	Eps8	0,4	Src	Eps8	20779(Tax:10090)	13860(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Eps8 controls Src - and FAK-dependent phenotypes in squamous_carcinoma cells .
15753384	0	Src	15,18	ErbB2	0,5	Src	ErbB2	6714	2064	Gene	Gene	synthesis|compound|START_ENTITY promotes|dobj|synthesis promotes|nsubj|END_ENTITY	ErbB2 promotes Src synthesis and stability : novel mechanisms of Src activation that confer breast_cancer metastasis .
25118939	0	Src	17,20	FAK	0,3	Src	FAK	20779(Tax:10090)	14083(Tax:10090)	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	FAK competes for Src to promote migration against invasion in melanoma cells .
26914403	0	Src	51,54	FAK	46,49	Src	FAK	6714	5747	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
16169515	0	Src	0,3	FHOD1	59,64	Src	FHOD1	6714	29109	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Src regulates the activity of the mammalian formin protein FHOD1 .
15007172	0	Src	53,56	Fhit	0,4	Src	Fhit	6714	2272	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Fhit is a physiological target of the protein kinase Src .
16884713	0	Src	53,56	Fibroblast_growth_factor-2	0,26	Src	Fibroblast growth factor-2	20779(Tax:10090)	14173(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Fibroblast_growth_factor-2 induces the activation of Src through Fes , which regulates focal_adhesion disassembly .
26914403	0	Src	51,54	GPER	40,44	Src	GPER	6714	2852	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Bisphenol_A induces migration through a GPER , FAK , Src and ERK2-dependent pathway in MDA-MB-231 breast_cancer cells .
11313907	0	Src	49,52	G_protein_coupled_receptor	0,26	Src	G protein coupled receptor	6714	10663	Gene	Gene	pathway|compound|START_ENTITY signaling|nmod|pathway END_ENTITY|acl|signaling	G_protein_coupled_receptor signaling through the Src and Stat3 pathway : role in proliferation and transformation .
12941962	0	Src	0,3	Grb2-associated_binder_1	19,43	Src	Grb2-associated binder 1	20779(Tax:10090)	14388(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Src phosphorylates Grb2-associated_binder_1 upon hepatocyte_growth_factor stimulation .
21335603	0	Src	0,3	HIF-1a	14,20	Src	HIF-1a	6714	3091	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Src activates HIF-1a not through direct phosphorylation of HIF-1a specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway .
21335603	0	Src	0,3	HIF-1a	59,65	Src	HIF-1a	6714	3091	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|phosphorylation phosphorylation|nmod|hydroxylase hydroxylase|amod|specific specific|amod|END_ENTITY	Src activates HIF-1a not through direct phosphorylation of HIF-1a specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway .
22390300	0	Src	70,73	HIF-1a	16,22	Src	HIF-1a	6714	3091	Gene	Gene	activation|compound|START_ENTITY blocking|dobj|activation suppresses|advcl|blocking suppresses|dobj|expression expression|amod|END_ENTITY	KAI1 suppresses HIF-1a and VEGF expression by blocking CDCP1-enhanced Src activation in prostate_cancer .
27065329	0	Src	22,25	HLJ1	0,4	Src	HLJ1	6714	11080	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nsubj|END_ENTITY	HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms .
22308320	0	Src	0,3	HNF4a	103,108	Src	HNF4a	6714	3172	Gene	Gene	phosphorylation|compound|START_ENTITY correlates|nsubj|phosphorylation correlates|nmod|loss loss|nmod|END_ENTITY	Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon_cancer .
22308320	0	Src	0,3	HNF4a	56,61	Src	HNF4a	6714	3172	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src tyrosine kinase phosphorylation of nuclear receptor HNF4a correlates with isoform-specific loss of HNF4a in human colon_cancer .
16771830	0	Src	71,74	IL-1beta	0,8	Src	IL-1beta	20779(Tax:10090)	16176(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior_hypothalamic neurons .
14767470	0	Src	115,118	Interleukin-8	0,13	Src	Interleukin-8	20779(Tax:10090)	20309(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY growth|dep|effects confers|dobj|growth confers|nsubj|END_ENTITY	Interleukin-8 confers androgen-independent growth and migration of LNCaP : differential effects of tyrosine kinases Src and FAK .
10634792	0	Src	21,24	JNK	14,17	Src	JNK	48973(Tax:7227)	44801(Tax:7227)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of JNK by Src during Drosophila development .
10766791	0	Src	0,3	JNK	20,23	Src	JNK	20779(Tax:10090)	26419(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|compound|END_ENTITY	Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species .
14996948	0	Src	38,41	Kappa-opioid_receptor	0,21	Src	Kappa-opioid receptor	6714	4986	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Kappa-opioid_receptor signals through Src and focal_adhesion_kinase to stimulate c-Jun_N-terminal_kinases in transfected COS-7 cells and human monocytic THP-1 cells .
25237194	0	Src	56,59	Kindlin-2	0,9	Src	Kindlin-2	20779(Tax:10090)	218952(Tax:10090)	Gene	Gene	Serve|compound|START_ENTITY Phosphorylation|nmod|Serve Phosphorylation|compound|END_ENTITY	Kindlin-2 Tyrosine Phosphorylation and Interaction with Src Serve as a Regulatable Switch in the Integrin_Outside-in Signaling Circuit .
26037143	0	Src	29,32	Kindlin-2	0,9	Src	Kindlin-2	6714	10979	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions .
26037143	0	Src	50,53	Kindlin-2	0,9	Src	Kindlin-2	6714	10979	Gene	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions .
10642173	0	Src	12,15	Nef	50,53	Src	Nef	20779(Tax:10090)	6285	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo .
23882690	0	Src	27,30	PKCa	8,12	Src	PKCa	83805(Tax:10116)	24680(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|compound|END_ENTITY	Role of PKCa activation of Src , PI-3K / AKT , and ERK in EGF-stimulated proliferation of rat and human conjunctival goblet cells .
20421451	0	Src	49,52	PKCgamma	15,23	Src	PKCgamma	6714	5582	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic_retinal_neovascularization .
15792837	0	Src	2,5	PP1	24,27	Src	PP1	6714	5464	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	A Src family inhibitor -LRB- PP1 -RRB- potentiates tumor-suppressive effect of connexin_32 gene in renal_cancer cells .
12947324	11	Src	1452,1455	PP2	1467,1470	p38	p38	1432	1432	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	The Src inhibitor , PP2 , prevented only the LPS-induced earlier phosphorylation after oxidant stress and had no effect on LPS activation of p38 alone .
16949254	0	Src	113,116	PP2	131,134	Src	PP2	6714	4888	Gene	Gene	START_ENTITY|acl|inhibition inhibition|nmod|END_ENTITY	Role of Src in angiopoietin_1-induced capillary morphogenesis of endothelial cells : Effect of chronic hypoxia on Src inhibition by PP2 .
12576483	0	Src	95,98	PSD-95	121,127	Src	PSD-95	20779(Tax:10090)	13385(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY Pyk2|nmod|complex Interaction|nmod|Pyk2 homology|nsubj|Interaction homology|dobj|domains domains|nmod|END_ENTITY	Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 .
12618293	0	Src	116,119	PSD-95	140,146	Src	PSD-95	83805(Tax:10116)	29495(Tax:10116)	Gene	Gene	2A|nmod|START_ENTITY 2A|acl|mediated mediated|nmod|END_ENTITY	Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain_ischemia .
16990796	0	Src	54,57	PSD-95	0,6	Src	PSD-95	6714	1742	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex .
20197063	0	Src	43,46	PSD-95	26,32	Src	PSD-95	83805(Tax:10116)	29495(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS -LRB- Ser847 -RRB- phosphorylation contributing to neuroprotection after cerebral_ischemia .
12006995	0	Src	49,52	PTPalpha	70,78	Src	PTPalpha	20779(Tax:10090)	19262(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	-LSB- Changes of phenotypes associated with activated Src by overexpressed PTPalpha in NIH3T3 cells -RSB- .
12014986	0	Src	141,144	Phospholipase_D1	0,16	Src	Phospholipase D1	6714	5337	Gene	Gene	kinase|amod|START_ENTITY involving|dobj|kinase mechanism|acl|involving stimulated|nmod|mechanism cells|acl|stimulated threonine-phosphorylated|nmod|cells threonine-phosphorylated|nsubj|END_ENTITY	Phospholipase_D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta .
17146759	0	Src	36,39	Phospholipase_D1	0,16	Src	Phospholipase D1	6714	5337	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Phospholipase_D1 activation through Src and Ras is involved in basic_fibroblast_growth_factor-induced neurite outgrowth of H19-7 cells .
12826681	0	Src	31,34	Protein_kinase_C_delta	0,22	Src	Protein kinase C delta	83805(Tax:10116)	170538(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Protein_kinase_C_delta induces Src kinase activity via activation of the protein tyrosine phosphatase PTP alpha .
12576483	0	Src	95,98	Pyk2	35,39	Src	Pyk2	20779(Tax:10090)	19229(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 and SAP102 .
12400005	0	Src	33,36	RACK1	0,5	Src	RACK1	20779(Tax:10090)	14694(Tax:10090)	Gene	Gene	kinase|compound|START_ENTITY substrate|nmod|kinase END_ENTITY|dep|substrate	RACK1 : a novel substrate for the Src protein-tyrosine kinase .
15254245	0	Src	48,51	RACK1	0,5	Src	RACK1	20779(Tax:10090)	14694(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY suppressing|dobj|activity regulates|advcl|suppressing regulates|nsubj|END_ENTITY	RACK1 regulates G1/S progression by suppressing Src kinase activity .
17574549	0	Src	16,19	RACK1	0,5	Src	RACK1	6714	10399	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	RACK1 regulates Src activity and modulates paxillin dynamics during cell migration .
19767770	0	Src	56,59	RACK1	34,39	Src	RACK1	20779(Tax:10090)	14694(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY suppression|nmod|activity function|dep|suppression function|nmod|END_ENTITY	A novel pro-apoptotic function of RACK1 : suppression of Src activity in the intrinsic and Akt pathways .
20483033	0	Src	54,57	RACK1	0,5	Src	RACK1	20779(Tax:10090)	14694(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY re-exposure|nmod|inhibition inhibits|dobj|re-exposure inhibits|nsubj|END_ENTITY	RACK1 inhibits morphine re-exposure via inhibition of Src .
26528796	0	Src	106,109	RANKL	86,91	Src	RANKL	20779(Tax:10090)	21943(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Myristoleic_acid inhibits osteoclast formation and bone resorption by suppressing the RANKL activation of Src and Pyk2 .
19321744	0	Src	0,3	RhoGDI2	23,30	Src	RhoGDI2	6714	397	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function .
20547754	0	Src	102,105	RhoU	49,53	Src	RhoU	6714	58480	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Regulation of the Rho family small GTPase Wrch-1 / RhoU by C-terminal tyrosine phosphorylation requires Src .
7534229	0	Src	27,30	SH3	31,34	Src	Src	20779(Tax:10090)	20779(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Mutational analysis of the Src SH3 domain : the same residues of the ligand binding surface are important for intra - and intermolecular interactions .
12972574	0	Src	17,20	SHP-1	84,89	Src	SHP-1	6714	5777	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|nmod|END_ENTITY	Critical role of Src and SHP-2 in sst2 somatostatin receptor-mediated activation of SHP-1 and inhibition of cell proliferation .
24996174	0	Src	0,3	SIRT2	30,35	Src	SIRT2	6714	22933	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Src regulates the activity of SIRT2 .
10688651	0	Src	79,82	STAT3	86,91	Src	STAT3	20779(Tax:10090)	20848(Tax:10090)	Gene	Gene	linking|dobj|START_ENTITY linking|nmod|activation activation|compound|END_ENTITY	Etk , a Btk family tyrosine kinase , mediates cellular transformation by linking Src to STAT3 activation .
11114718	0	Src	58,61	STAT3	114,119	Src	STAT3	20779(Tax:10090)	20848(Tax:10090)	Gene	Gene	oncoprotein|compound|START_ENTITY Induction|nmod|oncoprotein Induction|dep|role role|nmod|signaling signaling|compound|END_ENTITY	Induction of p21WAF1/CIP1 and cyclin_D1 expression by the Src oncoprotein in mouse fibroblasts : role of activated STAT3 signaling .
12244095	0	Src	27,30	STAT3	14,19	Src	STAT3	83805(Tax:10116)	25125(Tax:10116)	Gene	Gene	Hck|compound|START_ENTITY END_ENTITY|nmod|Hck	Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain .
17575268	0	Src	86,89	STAT3	24,29	Src	STAT3	6714	6774	Gene	Gene	family|nmod|START_ENTITY factors|nmod|family kinases|nsubj|factors END_ENTITY|acl:relcl|kinases	Acute alcohol activates STAT3 , AP-1 , and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes .
19223541	0	Src	10,13	STAT3	88,93	Src	STAT3	6714	6774	Gene	Gene	inhibition|nsubj|START_ENTITY inhibition|dobj|results results|nmod|activation activation|appos|END_ENTITY	Sustained Src inhibition results in signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding .
20881478	0	Src	56,59	STAT3	76,81	Src	STAT3	6714	6774	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation .
9315091	0	Src	23,26	Sam68	37,42	Src	Sam68	6714	10657	Gene	Gene	Phosphorylation|nmod|START_ENTITY substrate|nsubj|Phosphorylation substrate|dobj|END_ENTITY	Phosphorylation of the Src substrate Sam68 by Cdc2 during mitosis .
9692543	0	Src	160,163	Src	96,99	Src	Src	83805(Tax:10116)	83805(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity phosphorylation-dependent|dep|regulation phosphorylation-dependent|dep|associations associations|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	Src	96,99	Src	160,163	Src	Src	83805(Tax:10116)	83805(Tax:10116)	Gene	Gene	associations|nmod|START_ENTITY phosphorylation-dependent|dep|associations phosphorylation-dependent|dep|regulation regulation|nmod|activity activity|compound|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
10523640	0	Src	125,128	Stat3	79,84	Src	Stat3	6714	6774	Gene	Gene	oncoprotein|compound|START_ENTITY induced|nmod|oncoprotein induced|nsubj|Requirement Requirement|nmod|p38 p38|nmod|activity activity|amod|END_ENTITY	Requirement for Ras/Rac1-mediated p38 and c-Jun_N-terminal_kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein .
10815799	0	Src	93,96	Stat3	14,19	Src	Stat3	6714	6774	Gene	Gene	activity|compound|START_ENTITY requires|dobj|activity requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity .
11940572	0	Src	34,37	Stat3	17,22	Src	Stat3	6714	6774	Gene	Gene	manner|amod|START_ENTITY alpha|nmod|manner alpha|nsubj|END_ENTITY	ErbB-2 activates Stat3 alpha in a Src - and JAK2-dependent manner .
16546976	0	Src	21,24	Stat3	111,116	Src	Stat3	6714	6774	Gene	Gene	signaling|nsubj|START_ENTITY signaling|dobj|apoptosis apoptosis|nmod|cells cells|acl|containing containing|dobj|protein protein|nummod|END_ENTITY	Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein .
16871430	0	Src	0,3	Stat3	18,23	Src	Stat3	6714	6774	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic_adenocarcinoma cells .
18314882	0	Src	124,127	Stat3	95,100	Src	Stat3	6714	6774	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Alpha-1 adrenergic receptor transactivates signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- through activation of Src and epidermal_growth_factor_receptor -LRB- EGFR -RRB- in hepatocytes .
9566874	0	Src	20,23	Stat3	0,5	Src	Stat3	20779(Tax:10090)	20848(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Stat3 activation by Src induces specific gene regulation and is required for cell transformation .
25371038	0	Src	69,72	TACE	87,91	Src	TACE	83805(Tax:10116)	57027(Tax:10116)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	TNFa shedding in Mechanically Stressed Cardiomyocytes is mediated by Src Activation of TACE .
17440088	0	Src	0,3	TGF-beta_type_II_receptor	29,54	Src	TGF-beta type II receptor	6714	7048	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|nmod|END_ENTITY	Src phosphorylates Tyr284 in TGF-beta_type_II_receptor and regulates TGF-beta stimulation of p38 MAPK during breast_cancer cell proliferation and invasion .
25585026	0	Src	24,27	TGFb1	0,5	Src	TGFb1	20779(Tax:10090)	21803(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TGFb1 rapidly activates Src through a non-canonical redox signaling mechanism .
26461366	0	Src	24,27	TGFb1	0,5	Src	TGFb1	6714	7040	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TGFb1 rapidly activates Src through a non-canonical redox mechanism .
11741951	0	Src	96,99	TNF-related_activation-induced_cytokine	0,39	Src	TNF-related activation-induced cytokine	6714	8600	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	TNF-related_activation-induced_cytokine -LRB- TRANCE -RRB- induces angiogenesis through the activation of Src and phospholipase C -LRB- PLC -RRB- in human endothelial cells .
21278788	0	Src	119,122	Translationally_controlled_tumor_protein	0,40	Src	Translationally controlled tumor protein	6714	7178	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Translationally_controlled_tumor_protein induces human breast epithelial cell transformation through the activation of Src .
10585422	0	Src	74,77	TrkA	67,71	Src	TrkA	83805(Tax:10116)	59109(Tax:10116)	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Adenosine_A -LRB- 2A -RRB- _ receptor mRNA regulation by nerve_growth_factor is TrkA - , Src - , and Ras-dependent via extracellular regulated kinase and stress-activated protein kinase/c-Jun NH -LRB- 2 -RRB- - terminal kinase .
14988025	0	Src	22,25	TrkA	69,73	Src	TrkA	6714	4914	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Constitutively active Src facilitates NGF-induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells .
16168405	0	Src	23,26	Uroplakin_III	0,13	Src	Uroplakin III	380430(Tax:8355)	398743(Tax:8355)	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	Uroplakin_III , a novel Src substrate in Xenopus egg rafts , is a target for sperm protease essential for fertilization .
16685275	0	Src	118,121	Vascular_endothelial_growth_factor	0,34	Src	Vascular endothelial growth factor	6714	7422	Gene	Gene	kinases|compound|START_ENTITY activation|nmod|kinases mediates|nmod|activation mediates|nsubj|receptor-1 receptor-1|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor-1 mediates migration of human colorectal_carcinoma cells by activation of Src family kinases .
17079466	0	Src	85,88	androgen_receptor	32,49	Src	androgen receptor	6714	367	Gene	Gene	pathway|compound|START_ENTITY involvement|nmod|pathway activation|dep|involvement activation|nmod|END_ENTITY	Inappropriate activation of the androgen_receptor by nonsteroids : involvement of the Src kinase pathway and its therapeutic implications .
17486077	0	Src	49,52	androgen_receptor	60,77	Src	androgen receptor	6714	367	Gene	Gene	binding|nmod|START_ENTITY domain-mediated|dobj|binding domain-mediated|nmod|END_ENTITY	Inhibition of the SH3 domain-mediated binding of Src to the androgen_receptor and its effect on tumor growth .
18223692	0	Src	0,3	androgen_receptor	23,40	Src	androgen receptor	20779(Tax:10090)	11835(Tax:10090)	Gene	Gene	potentiates|compound|START_ENTITY END_ENTITY|nsubj|potentiates	Src kinase potentiates androgen_receptor transactivation function and invasion of androgen-independent prostate_cancer C4-2 cells .
24130806	0	Src	28,31	androgen_receptor	10,27	Src	androgen receptor	6714	367	Gene	Gene	complex|compound|START_ENTITY impairs|nsubj|complex END_ENTITY|parataxis|impairs	Targeting androgen_receptor / Src complex impairs the aggressive phenotype of human fibrosarcoma cells .
15898100	0	Src	30,33	beta-catenin	70,82	Src	beta-catenin	6714	1499	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells .
15923620	0	Src	7,10	beta-catenin	38,50	Src	beta-catenin	6714	1499	Gene	Gene	elevates|nsubj|START_ENTITY elevates|dobj|expression expression|nmod|END_ENTITY	Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation .
15039213	0	Src	87,90	c-Kit	38,43	Src	c-Kit	6714	3815	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic_cancer .
17552361	0	Src	14,17	c-Met	21,26	Src	c-Met	6714	4233	Gene	Gene	START_ENTITY|nmod|overexpression overexpression|amod|END_ENTITY	Activation of Src by c-Met overexpression mediates metastatic properties of colorectal_carcinoma cells .
11847100	0	Src	24,27	c-myc	54,59	Src	c-myc	6714	4609	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis .
9675253	0	Src	67,70	cGMP-dependent_protein_kinase	34,63	Src	cGMP-dependent protein kinase	6714	5592	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of cGMP-dependent_protein_kinase by Src .
20127031	0	Src	0,3	carbonic_anhydrase_IX	26,47	Src	carbonic anhydrase IX	6714	768	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Src induces expression of carbonic_anhydrase_IX via hypoxia-inducible_factor_1 .
17956757	0	Src	41,44	connexin43	19,29	Src	connexin43	6714	2697	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Phosphorylation of connexin43 induced by Src : regulation of gap junctional communication between transformed cells .
10075710	0	Src	25,28	cortactin	77,86	Src	cortactin	6714	2017	Gene	Gene	kinases|nsubj|START_ENTITY kinases|dobj|phosphorylation phosphorylation|nmod|exchangers exchangers|amod|END_ENTITY	Cell shrinkage regulates Src kinases and induces tyrosine phosphorylation of cortactin , independent of the osmotic regulation of Na + / H + exchangers .
16385081	0	Src	46,49	cortactin	17,26	Src	cortactin	6714	2017	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro .
17606906	0	Src	0,3	cortactin	23,32	Src	cortactin	6714	2017	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src phosphorylation of cortactin enhances actin assembly .
19038333	0	Src	117,120	cortactin	20,29	Src	cortactin	6714	2017	Gene	Gene	interdependence|nmod|START_ENTITY Characterization|dep|interdependence Characterization|nmod|END_ENTITY	Characterization of cortactin as an in vivo protein_kinase_D substrate : interdependence of sites and potentiation by Src .
23097045	0	Src	0,3	cortactin	10,19	Src	cortactin	6714	2017	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Src binds cortactin through an SH2 domain cystine-mediated linkage .
26043691	0	Src	0,3	cortactin	27,36	Src	cortactin	6714	2017	Gene	Gene	tyrosyl|compound|START_ENTITY phosphorylates|nsubj|tyrosyl phosphorylates|dobj|END_ENTITY	Src tyrosyl phosphorylates cortactin in response to prolactin .
7592885	0	Src	37,40	cortactin	7,16	Src	cortactin	20779(Tax:10090)	13043(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY associates|nmod|domain associates|compound|END_ENTITY	p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells .
7685657	0	Src	61,64	csk	18,21	Src	csk	20779(Tax:10090)	12988(Tax:10090)	Gene	Gene	kinases|compound|START_ENTITY regulator|nmod|kinases encoding|dobj|regulator leads|advcl|encoding leads|nsubj|Disruption Disruption|nmod|gene gene|compound|END_ENTITY	Disruption of the csk gene , encoding a negative regulator of Src family tyrosine kinases , leads to neural tube defects and embryonic_lethality in mice .
21411625	0	Src	120,123	dynamin-2	46,55	Src	dynamin-2	6714	1785	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|interaction interaction|nmod|END_ENTITY	A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src .
8637106	0	Src	85,88	endothelin-1	57,69	Src	endothelin-1	6714	1906	Gene	Gene	involvement|nmod|START_ENTITY involvement|amod|END_ENTITY	Modulation of monocyte adherence to endothelial cells by endothelin-1 involvement of Src -LRB- p60src -RRB- and JAK1-like kinases .
11274221	0	Src	0,3	epidermal_growth_factor_receptor	62,94	Src	epidermal growth factor receptor	20779(Tax:10090)	13649(Tax:10090)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|activation activation|nmod|END_ENTITY	Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- but are not required for coupling to the mitogen-activated_protein -LRB- MAP -RRB- kinase signaling cascade .
11882594	0	Src	34,37	epidermal_growth_factor_receptor	52,84	Src	epidermal growth factor receptor	83805(Tax:10116)	24329(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|transactivation transactivation|compound|END_ENTITY	Increased angiotensin_II-mediated Src signaling via epidermal_growth_factor_receptor transactivation is associated with decreased C-terminal_Src_kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats .
15110780	0	Src	90,93	epidermal_growth_factor_receptor	111,143	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal_growth_factor_receptor transactivation .
16532343	0	Src	10,13	epidermal_growth_factor_receptor	100,132	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|activation activation|acl|signaling signaling|dobj|downstream downstream|nmod|END_ENTITY	Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal_growth_factor_receptor in human gallbladder_adenocarcinoma cells .
18667434	0	Src	78,81	epidermal_growth_factor_receptor	19,51	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	activity|compound|START_ENTITY regulate|dobj|activity recruits|xcomp|regulate recruits|nsubj|END_ENTITY	The transactivated epidermal_growth_factor_receptor recruits Pyk2 to regulate Src kinase activity .
18794807	0	Src	14,17	epidermal_growth_factor_receptor	135,167	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	kinase|compound|START_ENTITY Inhibition|nmod|kinase reverts|nsubj|Inhibition reverts|dobj|chemoresistance chemoresistance|dep|involvement involvement|nmod|END_ENTITY	Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic_carcinoma cells : an involvement of epidermal_growth_factor_receptor signaling .
23349873	0	Src	134,137	epidermal_growth_factor_receptor	36,68	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	oxidation|nmod|START_ENTITY involves|dobj|oxidation involves|nsubj|transactivation transactivation|nmod|END_ENTITY	ATP-mediated transactivation of the epidermal_growth_factor_receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17 .
25338626	0	Src	53,56	epidermal_growth_factor_receptor	59,91	Src	epidermal growth factor receptor	20779(Tax:10090)	13649(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY species|dep|activation species|dep|END_ENTITY	Reactive oxygen species - mediated activation of the Src - epidermal_growth_factor_receptor - Akt signaling cascade prevents bortezomib - induced apoptosis in hepatocellular_carcinoma cells .
7608194	0	Src	131,134	epidermal_growth_factor_receptor	31,63	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	SH2|compound|START_ENTITY domains|nsubj|SH2 lacking|xcomp|domains substrates|xcomp|lacking substrates|nsubj|requirements requirements|nmod|END_ENTITY	Structural requirements of the epidermal_growth_factor_receptor for tyrosine phosphorylation of eps8 and eps15 , substrates lacking Src SH2 homology domains .
7797556	0	Src	0,3	epidermal_growth_factor_receptor	27,59	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Src phosphorylation of the epidermal_growth_factor_receptor at novel sites mediates receptor interaction with Src and P85_alpha .
7797556	0	Src	110,113	epidermal_growth_factor_receptor	27,59	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Src phosphorylation of the epidermal_growth_factor_receptor at novel sites mediates receptor interaction with Src and P85_alpha .
9374500	0	Src	27,30	epidermal_growth_factor_receptor	84,116	Src	epidermal growth factor receptor	6714	1956	Gene	Gene	Overexpression|nmod|START_ENTITY enhances|nsubj|Overexpression enhances|dobj|internalization internalization|nmod|END_ENTITY	Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal_growth_factor_receptor .
15623525	0	Src	0,3	ezrin	19,24	Src	ezrin	6714	7430	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member .
8794768	0	Src	92,95	growth_factor_receptor-bound_protein_2	53,91	Src	growth factor receptor-bound protein 2	6714	2885	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Nuclear magnetic resonance solution structure of the growth_factor_receptor-bound_protein_2 Src homology 2 domain .
16914530	0	Src	29,32	leupaxin	15,23	Src	leupaxin	20779(Tax:10090)	107321(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of leupaxin with Src in osteoclasts .
10418104	0	Src	57,60	moesin	47,53	Src	moesin	380430(Tax:8355)	735107(Tax:8355)	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	Identification and characterisation of Xenopus moesin , a Src substrate in Xenopus_laevis oocytes .
8621540	0	Src	73,76	p130Cas	39,46	Crk	p130Cas	12928(Tax:10090)	12927(Tax:10090)	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase .
17254967	0	Src	23,26	p27	0,3	Src	p27	6714	10671	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 .
26466383	0	Src	0,3	p38	63,66	Src	p38	83805(Tax:10116)	81649(Tax:10116)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38 , ERK/AP -1 Signaling and COX-2 Expression in YPEN-1 Cells .
8643668	0	Src	31,34	p53bp2	85,91	Src	p53bp2	6714	7159	Gene	Gene	preferences|nmod|START_ENTITY homology|nsubj|preferences homology|nmod|Crk Crk|appos|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
8643668	0	Src	59,62	p53bp2	85,91	Src	p53bp2	6714	7159	Gene	Gene	Crk|compound|START_ENTITY Crk|appos|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
11576548	0	Src	14,17	phosphatase_2A	53,67	Src	phosphatase 2A	6714	5524	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Src by direct interaction with protein phosphatase_2A .
9692543	0	Src	160,163	protein_kinase_C-delta	190,212	Src	protein kinase C-delta	83805(Tax:10116)	170538(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	Src	160,163	protein_kinase_C-delta	68,90	Src	protein kinase C-delta	83805(Tax:10116)	170538(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity phosphorylation-dependent|dep|regulation phosphorylation-dependent|dep|associations associations|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	Src	96,99	protein_kinase_C-delta	190,212	Src	protein kinase C-delta	83805(Tax:10116)	170538(Tax:10116)	Gene	Gene	associations|nmod|START_ENTITY phosphorylation-dependent|dep|associations phosphorylation-dependent|dep|regulation regulation|nmod|activity activity|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	Src	96,99	protein_kinase_C-delta	68,90	Src	protein kinase C-delta	83805(Tax:10116)	170538(Tax:10116)	Gene	Gene	associations|nmod|START_ENTITY associations|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
11812791	0	Src	0,3	protein_kinase_C_delta	33,55	Src	protein kinase C delta	20779(Tax:10090)	18753(Tax:10090)	Gene	Gene	START_ENTITY|ccomp|phosphorylate phosphorylate|dobj|END_ENTITY	Src family kinases phosphorylate protein_kinase_C_delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes .
15546552	0	Src	96,99	sarcoma_protein	101,116	Src	sarcoma protein	20779(Tax:10090)	20779(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Extracellular pressure stimulates colon_cancer cell adhesion in vitro and to surgical wounds by Src -LRB- sarcoma_protein -RRB- activation .
21486047	0	Src	69,72	signal_transducer_and_activator_of_transcription_3	100,150	Src	signal transducer and activator of transcription 3	6714	6774	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 -LRB- SH2 -RRB- domain of signal_transducer_and_activator_of_transcription_3 .
12614335	0	Src	56,59	thrombin	63,71	Src	thrombin	83805(Tax:10116)	29251(Tax:10116)	Gene	Gene	START_ENTITY|nmod|signalling signalling|compound|END_ENTITY	The role of the Ca2 + - sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes .
17785844	0	Src	17,20	vascular_endothelial_cadherin	41,70	Src	vascular endothelial cadherin	6714	1003	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	ICAM-1-mediated , Src - and Pyk2-dependent vascular_endothelial_cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration .
11696015	0	Src	0,3	vascular_endothelial_growth_factor	28,62	Src	vascular endothelial growth factor	6714	7422	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Src mediates stimulation by vascular_endothelial_growth_factor of the phosphorylation of focal_adhesion_kinase at tyrosine 861 , and migration and anti-apoptosis in endothelial cells .
16054437	0	Src	14,17	vascular_endothelial_growth_factor	56,90	Src	vascular endothelial growth factor	20779(Tax:10090)	7422	Gene	Gene	Inhibition|nmod|START_ENTITY kinase|nsubj|Inhibition kinase|nmod|expression expression|compound|END_ENTITY	Inhibition of Src kinase activity by Ad-mda7 suppresses vascular_endothelial_growth_factor expression in prostate_carcinoma cells .
16909109	0	Src	0,3	vascular_endothelial_growth_factor	71,105	Src	vascular endothelial growth factor	6714	7422	Gene	Gene	kinase|compound|START_ENTITY phosphorylates|nsubj|kinase phosphorylates|dobj|endothelial-cadherin endothelial-cadherin|nmod|response response|nmod|END_ENTITY	Src kinase phosphorylates vascular endothelial-cadherin in response to vascular_endothelial_growth_factor : identification of tyrosine 685 as the unique target site .
23300935	0	Src-Like_adaptor_protein	0,24	Flt3	70,74	Src-Like adaptor protein	Flt3	6503	2322	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Src-Like_adaptor_protein -LRB- SLAP -RRB- binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling .
24284075	0	Src-like-adaptor_protein	0,24	c-Kit	78,83	Src-like-adaptor protein	c-Kit	6503	3815	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Src-like-adaptor_protein -LRB- SLAP -RRB- differentially regulates normal and oncogenic c-Kit signaling .
8825655	0	Src-like_adapter_protein	38,62	SLA	106,109	Src-like adapter protein	SLA	20491(Tax:10090)	6503	Gene	Gene	gene|compound|START_ENTITY localization|nmod|gene END_ENTITY|nsubj|localization	Chromosomal localization of the mouse Src-like_adapter_protein -LRB- Slap -RRB- gene and its putative human homolog SLA .
8825655	0	Src-like_adapter_protein	38,62	Slap	64,68	Src-like adapter protein	Slap	20491(Tax:10090)	20491(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization of the mouse Src-like_adapter_protein -LRB- Slap -RRB- gene and its putative human homolog SLA .
21220694	0	Src-like_adaptor_protein	4,28	GM-CSFR	39,46	Src-like adaptor protein	GM-CSFR	6503	1438	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|signaling signaling|compound|END_ENTITY	The Src-like_adaptor_protein regulates GM-CSFR signaling and monocytic dendritic cell maturation .
20828795	0	Src-like_adaptor_protein_2	9,35	SLAP-2	82,88	Src-like adaptor protein 2	SLAP-2	84174	84174	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of Src-like_adaptor_protein_2 -LRB- SLAP-2 -RRB- in GPVI-mediated platelet activation SLAP-2 and GPVI signaling .
11799143	0	Src-suppressed_C_kinase_substrate	13,46	SSeCKS	48,54	Src-suppressed C kinase substrate	SSeCKS	83397(Tax:10090)	83397(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of Src-suppressed_C_kinase_substrate -LRB- SSeCKS -RRB- in vascular endothelial cells by bacterial lipopolysaccharide .
16775001	0	Src64	29,34	Csk	0,3	Src64	Csk	48973(Tax:7227)	41398(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells .
8930392	0	Src64	46,51	corkscrew	94,103	Src64	corkscrew	48973(Tax:7227)	45278(Tax:7227)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Signaling by ectopically expressed Drosophila Src64 requires the protein-tyrosine phosphatase corkscrew and the adapter downstream_of_receptor_kinases .
8868476	0	Src_homologous_and_collagen-like	72,104	SHC	106,109	Src homologous and collagen-like	SHC	6464	6464	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	pH-Dependent self-association of the Src homology 2 -LRB- SH2 -RRB- domain of the Src_homologous_and_collagen-like -LRB- SHC -RRB- protein .
16682172	0	Src_homology_2-containing_inositol_5-phosphatase_1	4,54	CD32a	78,83	Src homology 2-containing inositol 5-phosphatase 1	CD32a	3635	2212	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The Src_homology_2-containing_inositol_5-phosphatase_1 -LRB- SHIP1 -RRB- is involved in CD32a signaling in human neutrophils .
16261333	0	Src_homology_2-containing_phosphotyrosine_phosphatase	0,53	epidermal_growth_factor_receptor	85,117	Src homology 2-containing phosphotyrosine phosphatase	epidermal growth factor receptor	25622(Tax:10116)	24329(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transactivation transactivation|compound|END_ENTITY	Src_homology_2-containing_phosphotyrosine_phosphatase regulates endothelin-1-induced epidermal_growth_factor_receptor transactivation in rat renal tubular cell NRK-52E .
15388330	0	Src_homology_2_domain-containing_leukocyte_phosphoprotein_of_76_kD	19,85	SLP-76	87,93	Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD	SLP-76	3937	3937	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of the Src_homology_2_domain-containing_leukocyte_phosphoprotein_of_76_kD -LRB- SLP-76 -RRB- with the p85 subunit of phosphoinositide_3-kinase .
21422245	0	Src_homology_domain_2-containing_tyrosine_phosphatase-1	56,111	IL-6	0,4	Src homology domain 2-containing tyrosine phosphatase-1	IL-6	15170(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|compound|END_ENTITY	IL-6 production is positively regulated by two distinct Src_homology_domain_2-containing_tyrosine_phosphatase-1 -LRB- SHP-1 -RRB- - dependent CCAAT/enhancer-binding protein b and NF-kB pathways and an SHP-1-independent NF-kB pathway in lipopolysaccharide-stimulated bone marrow-derived macrophages .
24439919	0	Src_homology_phosphotyrosyl_phosphatase_2	16,57	Shp2	59,63	Src homology phosphotyrosyl phosphatase 2	Shp2	5781	5781	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of Src_homology_phosphotyrosyl_phosphatase_2 -LRB- Shp2 -RRB- expression in oral_cancer and knockdown of Shp2 expression inhibit tumor cell viability and invasion in vitro .
16237056	0	Src_homology_region_2_domain-containing_phosphatase-1	112,165	TGF-beta1	0,9	Src homology region 2 domain-containing phosphatase-1	TGF-beta1	15170(Tax:10090)	21803(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4 + T cells through the protein tyrosine phosphatase Src_homology_region_2_domain-containing_phosphatase-1 .
19682428	0	Srebp-1c	27,35	Rev-erb_beta	0,12	Srebp-1c	Rev-erb beta	20787(Tax:10090)	353187(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY regulates|dobj|promoter regulates|nsubj|END_ENTITY	Rev-erb_beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells .
24993831	0	Srebp-1c	121,129	sterol_regulatory_element-binding_protein-1c	75,119	Srebp-1c	sterol regulatory element-binding protein-1c	20787(Tax:10090)	20787(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hepatic differentiated embryo-chondrocyte-expressed gene 1 -LRB- Dec1 -RRB- inhibits sterol_regulatory_element-binding_protein-1c -LRB- Srebp-1c -RRB- expression and alleviates fatty_liver phenotype .
23850470	0	Srebp1c	69,76	Tgf-b	80,85	Srebp1c	Tgf-b	6720	7040	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Regulation of brown adipogenesis by the Tgf-b family : involvement of Srebp1c in Tgf-b - and Activin-induced inhibition of adipogenesis .
20935679	0	Srg3	0,4	BAF155	25,31	Srg3	BAF155	20588(Tax:10090)	20588(Tax:10090)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Srg3 , a mouse homolog of BAF155 , is a novel p53 target and acts as a tumor suppressor by modulating p21 -LRB- WAF1/CIP1 -RRB- expression .
11604513	0	Srg3	0,4	SWI3	31,35	Srg3	SWI3	20588(Tax:10090)	853264(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Srg3 , a mouse homolog of yeast SWI3 , is essential for early embryogenesis and involved in brain development .
3478802	0	Sri	23,26	aid	16,19	Sri	aid	6717	57379	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Dental foreign aid in Sri Lanka -RSB- .
15931174	0	Srs2	28,32	PCNA	14,18	Srs2	PCNA	853353(Tax:4932)	852385(Tax:4932)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase .
19549635	0	Sry	45,48	WT1	27,30	Sry	WT1	21674(Tax:10090)	22431(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	A cell-autonomous role for WT1 in regulating Sry in vivo .
16571910	0	Sry	48,51	Wt1	30,33	Sry	Wt1	21674(Tax:10090)	22431(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of endogenous Wt1 expression by Sry transgene in the murine embryonic mesonephros-derived M15 cell line .
18624952	0	Sry-related_HMG_box_9	118,139	Sox9	141,145	Sry-related HMG box 9	Sox9	6662	6662	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Injectable growth/differentiation _ factor-5-recombinant human collagen composite induces endochondral ossification via Sry-related_HMG_box_9 -LRB- Sox9 -RRB- expression and angiogenesis in murine calvariae .
15843375	1	Ssa1	85,89	Hsp26	74,79	Ssa1	Hsp26	851259(Tax:4932)	852364(Tax:4932)	Gene	Gene	cooperation|nmod|START_ENTITY cooperation|nmod|END_ENTITY	The cooperation of Hsp26 with Ssa1 and Hsp104 .
11601843	0	Ssc1	46,50	Mge1	89,93	Ssc1	Mge1	853503(Tax:4932)	854407(Tax:4932)	Gene	Gene	proteins|appos|START_ENTITY compete|nsubj|proteins compete|nmod|END_ENTITY	The two mitochondrial heat_shock proteins 70 , Ssc1 and Ssq1 , compete for the cochaperone Mge1 .
9048947	0	Ssc1	50,54	Mge1	0,4	Ssc1	Mge1	853503(Tax:4932)	854407(Tax:4932)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Mge1 functions as a nucleotide release factor for Ssc1 , a mitochondrial Hsp70 of Saccharomyces_cerevisiae .
19962308	0	Ssd1	43,47	Cbk1	0,4	Ssd1	Cbk1	851887(Tax:4932)	855561(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Cbk1 regulation of the RNA-binding protein Ssd1 integrates cell fate with translational control .
21339329	0	Ssd1	79,83	Cbk1	10,14	Ssd1	Cbk1	851887(Tax:4932)	855561(Tax:4932)	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|kinase kinase|compound|END_ENTITY	The yeast Cbk1 kinase regulates mRNA localization via the mRNA-binding protein Ssd1 .
20977549	0	Ssd1p	25,30	CLN2	40,44	Ssd1p	CLN2	851887(Tax:4932)	855819(Tax:4932)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Saccharomyces_cerevisiae Ssd1p promotes CLN2 expression by binding to the 5 ' - untranslated region of CLN2 mRNA .
22713118	0	Sse1p	66,71	Msi3p	17,22	Sse1p	Msi3p	855998(Tax:4932)	855998(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Candida_albicans Msi3p , a homolog of the Saccharomyces_cerevisiae Sse1p of the Hsp70 family , is involved in cell growth and fluconazole tolerance .
9784390	0	Ssl2	25,29	Rad25	31,36	Ssl2	Rad25	854663(Tax:4932)	854663(Tax:4932)	Gene	Gene	requirement|nmod|START_ENTITY requirement|appos|END_ENTITY	The requirement of yeast Ssl2 -LRB- Rad25 -RRB- for the repair of cisplatin-damaged DNA .
18208393	0	Sso0909	40,47	ATPase	90,96	Sso0909	ATPase	1455158(Tax:273057)	24869471	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	The Sulfolobus_solfataricus AAA protein Sso0909 , a homologue of the eukaryotic ESCRT Vps4 ATPase .
9154842	0	Sst2p	46,51	Mpt5p	25,30	Sst2p	Mpt5p	851173(Tax:4932)	852697(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Saccharomyces_cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest .
16362371	0	Ssu72	73,78	Cak1	7,11	Ssu72	Cak1	855499(Tax:4932)	850515(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1 .
26569073	0	St2	17,20	Il-33	11,16	St2	Il-33	17082(Tax:10090)	77125(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY Effects|dep|pathway Effects|nmod|END_ENTITY	Effects of Il-33 / St2 pathway on alteration of iron and hematological parameters in acute inflammation .
24140593	0	StAR	60,64	BMP15	0,5	StAR	BMP15	6770	9210	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells .
26393302	0	StAR	42,46	Growth_Differentiation_Factor-8	0,31	StAR	Growth Differentiation Factor-8	6770	2660	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Growth_Differentiation_Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells .
18599618	0	StAR	60,64	NUR77	28,33	StAR	NUR77	6770	3164	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	The orphan nuclear receptor NUR77 regulates hormone-induced StAR transcription in Leydig cells through cooperation with Ca2 + / calmodulin-dependent protein kinase I. Cholesterol transport in the mitochondrial membrane , an essential step of steroid biosynthesis , is mediated by a protein complex containing the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
16574160	0	StAR	155,159	P450scc	102,109	StAR	P450scc	25557(Tax:10116)	29680(Tax:10116)	Gene	Gene	side-chain-cleavage|appos|START_ENTITY side-chain-cleavage|appos|END_ENTITY	Steroidogenic_impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage -LRB- P450scc -RRB- and steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- during experimental nephrotic_syndrome .
18001058	0	StAR	32,36	P450scc	83,90	StAR	P450scc	6770	1583	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Steroidogenic acute regulatory -LRB- StAR -RRB- protein and cholesterol side-chain cleavage -LRB- P450scc -RRB- as molecular and cellular targets for 17alpha-ethynylestradiol in salmon previtellogenic oocytes .
25140399	0	StAR	21,25	Smad3	83,88	StAR	Smad3	6770	4088	Gene	Gene	Expression|compound|START_ENTITY Pathways|nsubj|Expression Pathways|nmod|END_ENTITY	TGF-b1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells .
26393302	0	StAR	42,46	Smad3	80,85	StAR	Smad3	6770	4088	Gene	Gene	Expression|compound|START_ENTITY Pathways|nsubj|Expression Pathways|nmod|END_ENTITY	Growth_Differentiation_Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells .
10418988	0	StAR	127,131	Steroidogenic_Acute_Regulatory	95,125	StAR	Steroidogenic Acute Regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Effects of disruption of the mitochondrial electrochemical gradient on steroidogenesis and the Steroidogenic_Acute_Regulatory -LRB- StAR -RRB- protein .
17018137	0	StAR	40,44	Steroidogenic_acute_regulatory	0,30	StAR	Steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Steroidogenic_acute_regulatory protein -LRB- StAR -RRB- : evidence of gonadotropin-induced steroidogenesis in Alzheimer_disease .
18398688	0	StAR	32,36	Steroidogenic_acute_regulatory	0,30	StAR	Steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Steroidogenic_acute_regulatory -LRB- StAR -RRB- protein and cholesterol side-chain cleavage -LRB- P450scc -RRB- - regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish .
25140399	0	StAR	21,25	TGF-b1	0,6	StAR	TGF-b1	6770	7040	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells .
9155744	0	StAR	32,36	p25	47,50	StAR	p25	25557(Tax:10116)	170496(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Steroidogenic acute regulatory -LRB- StAR -RRB- protein -LRB- p25 -RRB- and prohibitin -LRB- p28 -RRB- from cultured rat ovarian granulosa cells .
11196450	0	StAR	86,90	steroid_acute_regulatory	60,84	StAR	steroid acute regulatory	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Properties of an adrenal medullary protein immunorelated to steroid_acute_regulatory -LRB- StAR -RRB- protein .
10026215	1	StAR	147,151	steroidogenic_acute_regulatory	115,145	StAR	steroidogenic acute regulatory	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Involvement of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
10220047	0	StAR	51,55	steroidogenic_acute_regulatory	19,49	StAR	steroidogenic acute regulatory	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Down-regulation of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in rat Leydig cells : implications for regulation of testosterone production during aging .
10919257	0	StAR	98,102	steroidogenic_acute_regulatory	66,96	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Interactive stimulation by luteinizing hormone and insulin of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein and 17alpha-hydroxylase/17 ,20 - lyase -LRB- CYP17 -RRB- genes in porcine theca cells .
10940480	0	StAR	61,65	steroidogenic_acute_regulatory	29,59	StAR	steroidogenic acute regulatory	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Expression of adrenocortical steroidogenic_acute_regulatory -LRB- StAR -RRB- protein is influenced by chromaffin cells .
11054639	0	StAR	103,107	steroidogenic_acute_regulatory	71,101	StAR	steroidogenic acute regulatory	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic_acute_regulatory -LRB- StAR -RRB- gene .
11410589	0	StAR	112,116	steroidogenic_acute_regulatory	80,110	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	ERKs regulate cyclic_AMP-induced steroid synthesis through transcription of the steroidogenic_acute_regulatory -LRB- StAR -RRB- gene .
11911955	0	StAR	70,74	steroidogenic_acute_regulatory	38,68	StAR	steroidogenic acute regulatory	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional repression of the rat steroidogenic_acute_regulatory -LRB- StAR -RRB- protein gene by the AP-1 family member c-Fos .
12810543	0	StAR	111,115	steroidogenic_acute_regulatory	79,109	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic_acute_regulatory -LRB- StAR -RRB- protein and steroidogenesis .
20416921	0	StAR	54,58	steroidogenic_acute_regulatory	14,44	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|protein protein|amod|END_ENTITY	Expression of steroidogenic_acute_regulatory protein -LRB- StAR -RRB- in male American bullfrog -LRB- Rana catesbeiana -RRB- and preliminary evaluation of the response to TNT .
21153110	0	StAR	58,62	steroidogenic_acute_regulatory	26,56	StAR	steroidogenic acute regulatory	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Prostaglandin_F2a reduces steroidogenic_acute_regulatory -LRB- StAR -RRB- protein messenger ribonucleic acid expression in the rat ovary .
21153282	0	StAR	55,59	steroidogenic_acute_regulatory	23,53	StAR	steroidogenic acute regulatory	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Hormonal regulation of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein messenger ribonucleic acid expression in the rat ovary .
23415713	0	StAR	56,60	steroidogenic_acute_regulatory	24,54	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression and roles of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in ` non-classical ' , extra-adrenal and extra-gonadal cells and tissues .
7548191	0	StAR	42,46	steroidogenic_acute_regulatory	10,40	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human steroidogenic_acute_regulatory -LRB- StAR -RRB- gene is expressed in the urogenital system and encodes a mitochondrial polypeptide .
7588386	0	StAR	50,54	steroidogenic_acute_regulatory	18,48	StAR	steroidogenic acute regulatory	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein : a novel LH-induced mitochondrial protein required for the acute regulation of steroidogenesis in mouse Leydig_tumor cells .
8660356	0	StAR	64,68	steroidogenic_acute_regulatory	32,62	StAR	steroidogenic acute regulatory	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Regulation of expression of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein by ACTH in bovine adrenal_fasciculata cells .
8828518	0	StAR	104,108	steroidogenic_acute_regulatory	72,102	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in Leydig cells .
8969904	0	StAR	125,129	steroidogenic_acute_regulatory	93,123	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	ATP and a mitochondrial electrochemical gradient are required for functional activity of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in isolated mitochondria .
8969905	0	StAR	79,83	steroidogenic_acute_regulatory	47,77	StAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Adrenocorticotropin regulates the level of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein mRNA in hamster adrenals .
9622308	0	StAR	134,138	steroidogenic_acute_regulatory	102,132	StAR	steroidogenic acute regulatory	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Possible involvement of calcium/calmodulin-dependent protein kinase in ACTH-induced expression of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in bovine adrenal_fasciculata cells .
10364248	0	StAR	130,134	steroidogenic_acute_regulatory_protein	90,128	StAR	steroidogenic acute regulatory protein	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	CCAAT enhancer-binding protein beta and GATA-4 binding regions within the promoter of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene are required for transcription in rat ovarian cells .
10473624	0	StAR	105,109	steroidogenic_acute_regulatory_protein	65,103	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	CCAAT/enhancer-binding _ proteins regulate expression of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene .
10541561	0	StAR	158,162	steroidogenic_acute_regulatory_protein	118,156	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Insulin and insulin-like growth factor-I and - II modulate human granulosa-lutein cell steroidogenesis : enhancement of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- expression .
10954035	0	StAR	54,58	steroidogenic_acute_regulatory_protein	14,52	StAR	steroidogenic acute regulatory protein	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in rat granulosa cells .
11196424	0	StAR	94,98	steroidogenic_acute_regulatory_protein	54,92	StAR	steroidogenic acute regulatory protein	443122(Tax:9940)	443122(Tax:9940)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	N-proopiomelanocortin -LRB- 1-77 -RRB- suppresses expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- mRNA in the adrenal gland of the fetal sheep .
16682116	0	StAR	74,78	steroidogenic_acute_regulatory_protein	34,72	StAR	steroidogenic acute regulatory protein	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional activation of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : GATA-4 and CCAAT/enhancer-binding _ protein_beta confer synergistic responsiveness in hormone-treated rat granulosa and HEK293 cell models .
17196197	0	StAR	67,71	steroidogenic_acute_regulatory_protein	27,65	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Hormonal regulation of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in gonadal tissues of the Atlantic croaker -LRB- Micropogonias undulatus -RRB- .
21647419	0	StAR	26,30	steroidogenic_acute_regulatory_protein	32,70	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of novel StAR -LRB- steroidogenic_acute_regulatory_protein -RRB- mutations causing non-classic lipoid_adrenal_hyperplasia .
25786521	0	StAR	82,86	steroidogenic_acute_regulatory_protein	42,80	StAR	steroidogenic acute regulatory protein	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cadmium up-regulates transcription of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene through phosphorylated CREB rather than SF-1 in K28 cells .
26100237	0	StAR	79,83	steroidogenic_acute_regulatory_protein	39,77	StAR	steroidogenic acute regulatory protein	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lysosomes are involved in induction of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene expression and progesterone synthesis through low-density lipoprotein in cultured bovine granulosa cells .
7547998	0	StAR	63,67	steroidogenic_acute_regulatory_protein	23,61	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : StAR stimulates mitochondrial cholesterol 27-hydroxylase activity .
8573184	0	StAR	52,56	steroidogenic_acute_regulatory_protein	12,50	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in steroidogenesis .
8703908	0	StAR	104,108	steroidogenic_acute_regulatory_protein	64,102	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Steroidogenic_factor_1-dependent promoter activity of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene .
8923870	0	StAR	54,58	steroidogenic_acute_regulatory_protein	14,52	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in the human ovary .
9029708	0	StAR	72,76	steroidogenic_acute_regulatory_protein	32,70	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulation of expression of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : a central role for steroidogenic_factor_1 .
9077535	1	StAR	209,213	steroidogenic_acute_regulatory_protein	169,207	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene .
9097960	0	StAR	56,60	steroidogenic_acute_regulatory_protein	16,54	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene in Japanese patients with congenital_lipoid_adrenal_hyperplasia .
9328229	0	StAR	109,113	steroidogenic_acute_regulatory_protein	69,107	StAR	steroidogenic acute regulatory protein	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Molecular cloning , characterization and cellular distribution of rat steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in the ovary .
9405483	0	StAR	59,63	steroidogenic_acute_regulatory_protein	19,57	StAR	steroidogenic acute regulatory protein	6770	6770	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- modulates its steroidogenic activity .
9888538	0	StAR	58,62	steroidogenic_acute_regulatory_protein	18,56	StAR	steroidogenic acute regulatory protein	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in bovine adrenocortical cells .
23911302	0	StH	62,65	Acc1	41,45	StH	Acc1	246744	31	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Phylogeny and molecular evolution of the Acc1 gene within the StH genome species in Triticeae -LRB- Poaceae -RRB- .
15064739	0	Staf50	0,6	p53	18,21	Staf50	p53	10346	7157	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells .
25056605	0	Stanniocalcin-1	0,15	PI3K	93,97	Stanniocalcin-1	PI3K	6781	5293	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Stanniocalcin-1 promotes metastasis in a human breast_cancer cell line through activation of PI3K .
21139325	0	Stanniocalcin-1	41,56	STC1	58,62	Stanniocalcin-1	STC1	100054071(Tax:9796)	100054071(Tax:9796)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of calcium maintenance factor Stanniocalcin-1 -LRB- STC1 -RRB- by the equine endometrium during the early pregnant period .
22933020	0	Stanniocalcin-1	0,15	angiotensin_II	77,91	Stanniocalcin-1	angiotensin II	81801(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Stanniocalcin-1 in the subfornical organ inhibits the dipsogenic response to angiotensin_II .
19786016	0	Stanniocalcin-2	0,15	HIF-1	21,26	Stanniocalcin-2	HIF-1	8614	3091	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Stanniocalcin-2 is a HIF-1 target gene that promotes cell proliferation in hypoxia .
26997225	0	Staphylococcal_nuclease_and_tudor_domain_containing_1	0,53	monoglyceride_lipase	105,125	Staphylococcal nuclease and tudor domain containing 1	monoglyceride lipase	27044	11343	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Staphylococcal_nuclease_and_tudor_domain_containing_1 -LRB- SND1 -RRB- promotes hepatocarcinogenesis by inhibiting monoglyceride_lipase -LRB- MGLL -RRB- .
23416977	0	Star-PAP	0,8	VP-16	67,72	Star-PAP	VP-16	64852	3054	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16 .
26048993	0	StarD10	35,42	LPCAT1	0,6	StarD10	LPCAT1	10809	79888	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	LPCAT1 Specifically Interacts with StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type_II_Cells .
10918594	0	Stat-1	43,49	IRF-1	115,120	Stat-1	IRF-1	6772	3659	Gene	Gene	apoptosis|amod|START_ENTITY apoptosis|nmod|induction induction|nmod|END_ENTITY	IFN-beta induces serine phosphorylation of Stat-1 in Ewing 's _ sarcoma cells and mediates apoptosis via induction of IRF-1 and activation of caspase-7 .
19049964	0	Stat-3	87,93	Transglutaminase-1	0,18	Stat-3	Transglutaminase-1	6774	7051	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3 .
20829349	0	Stat-5	22,28	Flt-3	50,55	Stat-5	Flt-3	6776	2322	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells .
21670504	0	Stat1	11,16	CD4	26,29	Stat1	CD4	20846(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Absence of Stat1 in donor CD4 T cells promotes the expansion of Tregs and reduces graft-versus-host_disease in mice .
11278462	0	Stat1	32,37	Focal_adhesion_kinase	0,21	Stat1	Focal adhesion kinase	20846(Tax:10090)	14083(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Focal_adhesion_kinase activates Stat1 in integrin-mediated cell migration and adhesion .
14565860	0	Stat1	31,36	IL-27	0,5	Stat1	IL-27	6772	246778	Gene	Gene	signal|nmod|START_ENTITY signal|nsubj|END_ENTITY	IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells .
11804954	0	Stat1	9,14	IRF-1	98,103	Stat1	IRF-1	6772	3659	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|regulation regulation|nmod|END_ENTITY	Roles of Stat1 , Stat2 , and interferon_regulatory_factor-9 -LRB- IRF-9 -RRB- in interferon tau regulation of IRF-1 .
14668793	0	Stat1	35,40	IRF-1	98,103	Stat1	IRF-1	6772	3659	Gene	Gene	activation|nmod|START_ENTITY enhances|dobj|activation enhances|nmod|interferon_gamma interferon_gamma|acl|leading leading|nmod|expression expression|nmod|END_ENTITY	Arsenic enhances the activation of Stat1 by interferon_gamma leading to synergistic expression of IRF-1 .
19034877	0	Stat1	36,41	Jak2	10,14	Stat1	Jak2	6772	3717	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery .
12642464	0	Stat1	62,67	P450	54,58	Stat1	P450	20846(Tax:10090)	1555	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice .
9581833	0	Stat1	20,25	Prolactin	0,9	Stat1	Prolactin	6772	5617	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Prolactin activates Stat1 but does not antagonize Stat1 activation and growth inhibition by type I interferons in human breast_cancer cells .
12923053	0	Stat1	0,5	Runx2	47,52	Stat1	Runx2	20846(Tax:10090)	12393(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation .
22838736	0	Stat1	0,5	Stat3	41,46	Stat1	Stat3	6772	6774	Gene	Gene	activation|amod|START_ENTITY attenuates|nsubj|activation attenuates|dobj|IL-6 IL-6|acl|induced induced|dobj|activity activity|amod|END_ENTITY	Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma .
26392462	0	Stat1	0,5	Stat3	92,97	Stat1	Stat3	20846(Tax:10090)	20848(Tax:10090)	Gene	Gene	Severity|compound|START_ENTITY Severity|nmod|END_ENTITY	Stat1 Regulates Lupus-like Chronic_Graft-versus-Host_Disease Severity via Interactions with Stat3 .
9153303	0	Stat1	142,147	Stat3	11,16	Stat1	Stat3	6772	6774	Gene	Gene	binding|nmod|START_ENTITY influence|nmod|binding has|dobj|influence serine|ccomp|has serine|nsubj|Mapping Mapping|nmod|END_ENTITY	Mapping of Stat3 serine phosphorylation to a single residue -LRB- 727 -RRB- and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3 .
16431927	0	Stat1	112,117	T-cell_protein-tyrosine_phosphatase	150,185	Stat1	T-cell protein-tyrosine phosphatase	6772	5771	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell_protein-tyrosine_phosphatase .
10652022	0	Stat1	66,71	interferon-gamma	19,35	Stat1	interferon-gamma	25124(Tax:10116)	25712(Tax:10116)	Gene	Gene	mutant|compound|START_ENTITY transfer|nmod|mutant signaling|nmod|transfer Down-regulation|acl|signaling Down-regulation|nmod|END_ENTITY	Down-regulation of interferon-gamma signaling by gene transfer of Stat1 mutant in mesangial cells .
16467883	0	Stat1	32,37	interferon-gamma	45,61	Stat1	interferon-gamma	6772	3458	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Modulation of the activation of Stat1 by the interferon-gamma receptor complex .
21321110	0	Stat1	42,47	interferon-gamma	66,82	Stat1	interferon-gamma	6772	3458	Gene	Gene	activation|nmod|START_ENTITY essential|nsubj|activation essential|nmod|END_ENTITY	Up-regulation and sustained activation of Stat1 are essential for interferon-gamma -LRB- IFN-gamma -RRB- - induced dual_oxidase_2 -LRB- Duox2 -RRB- and dual_oxidase_A2 -LRB- DuoxA2 -RRB- expression in human pancreatic_cancer cell lines .
24464587	0	Stat1	128,133	interferon-gamma	52,68	Stat1	interferon-gamma	20846(Tax:10090)	15978(Tax:10090)	Gene	Gene	/|dobj|START_ENTITY /|nsubj|mechanism mechanism|nmod|promotion promotion|nmod|END_ENTITY	A novel mechanism of skin_tumor promotion involving interferon-gamma -LRB- IFNy -RRB- / signal_transducer_and_activator_of_transcription-1 -LRB- Stat1 -RRB- signaling .
9389691	0	Stat1	161,166	interferon-gamma	118,134	Stat1	interferon-gamma	6772	3458	Gene	Gene	phosphorylation|nmod|START_ENTITY due|nmod|phosphorylation Inhibition|amod|due Inhibition|nmod|results results|nmod|predominance predominance|nmod|effects effects|nmod|END_ENTITY	Inhibition of interferon_regulatory_factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3 .
9491997	0	Stat1	113,118	interferon-gamma	55,71	Stat1	interferon-gamma	6772	3458	Gene	Gene	interaction|nmod|START_ENTITY requires|dobj|interaction requires|nsubj|Activation Activation|nmod|CIITA CIITA|nmod|END_ENTITY	Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1 .
17032168	0	Stat1	11,16	interleukin-1beta	65,82	Stat1	interleukin-1beta	20846(Tax:10090)	16176(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression .
20544543	0	Stat1	14,19	tumor_necrosis_factor-alpha	100,127	Stat1	tumor necrosis factor-alpha	6772	7124	Gene	Gene	Activation|nmod|START_ENTITY required|nsubjpass|Activation required|nmod|END_ENTITY	Activation of Stat1 , IRF-1 , and NF-kappaB is required for the induction of uridine phosphorylase by tumor_necrosis_factor-alpha and interferon-gamma .
18348986	0	Stat1/3	106,113	interleukin-6	30,43	Stat1/3	interleukin-6	6772;6774	3569	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	The proinflammatory cytokine , interleukin-6 , up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3 .
17651017	0	Stat2	21,26	JUND	41,45	Stat2	JUND	6773	3727	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Interferon-inducible Stat2 activation of JUND and CLDN4 : mediators of IFN responses .
10644731	0	Stat2	84,89	Stat4	15,20	Stat2	Stat4	6773	6775	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Recruitment Recruitment|nmod|END_ENTITY	Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2 .
25556369	0	Stat3	43,48	14-3-3	0,6	Stat3	14-3-3	6774	10971	Gene	Gene	Signaling|compound|START_ENTITY Regulates|nmod|Signaling Regulates|nsubj|END_ENTITY	14-3-3 Regulates Immune Response through Stat3 Signaling in Oral_Squamous_Cell_Carcinoma .
25754151	0	Stat3	43,48	14-3-3	0,6	Stat3	14-3-3	6774	10971	Gene	Gene	Signaling|compound|START_ENTITY Regulates|nmod|Signaling Regulates|nsubj|END_ENTITY	14-3-3 Regulates Immune Response through Stat3 Signaling in Oral_Squamous_Cell_Carcinoma .
11850821	0	Stat3	43,48	ALK	28,31	Stat3	ALK	6774	238	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|Anaplastic_lymphoma_kinase Anaplastic_lymphoma_kinase|appos|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- activates Stat3 and protects hematopoietic cells from cell death .
11850821	0	Stat3	43,48	Anaplastic_lymphoma_kinase	0,26	Stat3	Anaplastic lymphoma kinase	6774	238	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Anaplastic_lymphoma_kinase -LRB- ALK -RRB- activates Stat3 and protects hematopoietic cells from cell death .
21915376	0	Stat3	31,36	Angiotensin_II	54,68	Stat3	Angiotensin II	6774	183	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Jak2-Independent Activation of Stat3 by Intracellular Angiotensin_II in Human Mesangial Cells .
8798409	0	Stat3	53,58	Angiotensin_II	0,14	Stat3	Angiotensin II	6774	183	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	Angiotensin_II interferes with interleukin_6-induced Stat3 signaling by a pathway involving mitogen-activated_protein_kinase_kinase_1 .
9144332	0	Stat3	79,84	Angiotensin_II	0,14	Stat3	Angiotensin II	25125(Tax:10116)	24179(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates rapid serine phosphorylation of transcription factor Stat3 .
26738493	0	Stat3	51,56	B_cell_translocation_gene_2	0,27	Stat3	B cell translocation gene 2	20848(Tax:10090)	12227(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	B_cell_translocation_gene_2 -LRB- Btg2 -RRB- is regulated by Stat3 signaling and inhibits adipocyte differentiation .
24760274	0	Stat3	0,5	Beclin_1	15,23	Stat3	Beclin 1	6774	8678	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Stat3 inhibits Beclin_1 expression through recruitment of HDAC3 in nonsmall cell lung_cancer cells .
27022145	0	Stat3	75,80	CD4	23,26	Stat3	CD4	6774	920	Gene	Gene	mRNA|amod|START_ENTITY stabilization|nmod|mRNA regulates|nmod|stabilization regulates|dobj|fate fate|amod|naive naive|dep|END_ENTITY	Arid5a regulates naive CD4 + T cell fate through selective stabilization of Stat3 mRNA .
24005672	0	Stat3	131,136	CTGF	79,83	Stat3	CTGF	6774	1490	Gene	Gene	requires|dobj|START_ENTITY connective_tissue_growth_factor|acl:relcl|requires connective_tissue_growth_factor|appos|END_ENTITY	Transforming_growth_factor-b -LRB- TGF-b -RRB- - mediated connective_tissue_growth_factor -LRB- CTGF -RRB- expression in hepatic stellate cells requires Stat3 signaling activation .
26198700	0	Stat3	115,120	Cyclin-dependent_kinase_5	0,25	Stat3	Cyclin-dependent kinase 5	20848(Tax:10090)	12568(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY represses|nmod|phosphorylation represses|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727 .
17028263	0	Stat3	49,54	EGFR	78,82	Stat3	EGFR	20848(Tax:10090)	13649(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|activities activities|nmod|END_ENTITY	Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells .
22825581	0	Stat3	10,15	EGFR	26,30	Stat3	EGFR	6774	1956	Gene	Gene	abrogates|nsubj|START_ENTITY abrogates|dobj|resistance resistance|amod|END_ENTITY	Targeting Stat3 abrogates EGFR inhibitor resistance in cancer .
19151362	0	Stat3	38,43	ERK1/2	78,84	Stat3	ERK1/2	25125(Tax:10116)	50689;116590	Gene	Gene	START_ENTITY|nmod|cardiomyocytes cardiomyocytes|nmod|END_ENTITY	Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2 : role of sphingosine-1-phosphate .
21480396	0	Stat3	126,131	ERK1/2	157,163	Stat3	ERK1/2	20848(Tax:10090)	26417;26413	Gene	Gene	radiation|nmod|START_ENTITY involve|nsubj|radiation involve|nmod|END_ENTITY	Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase C with Stat3 involve integration with ERK1/2 .
12060494	0	Stat3	83,88	ERp57	71,76	Stat3	ERp57	6774	2923	Gene	Gene	glucose-regulated|nmod|START_ENTITY glucose-regulated|dobj|protein protein|appos|END_ENTITY	Association of the chaperone glucose-regulated protein 58 -LRB- GRP58/ER -60 / ERp57 -RRB- with Stat3 in cytosol and plasma membrane complexes .
8071311	0	Stat3	56,61	Epidermal_growth_factor	0,23	Stat3	Epidermal growth factor	20848(Tax:10090)	13645(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY activate|dobj|factor activate|nsubj|END_ENTITY	Epidermal_growth_factor and lipopolysaccharide activate Stat3 transcription factor in mouse liver .
11940572	0	Stat3	17,22	ErbB-2	0,6	Stat3	ErbB-2	6774	2064	Gene	Gene	alpha|nsubj|START_ENTITY activates|xcomp|alpha activates|nsubj|END_ENTITY	ErbB-2 activates Stat3 alpha in a Src - and JAK2-dependent manner .
20876300	0	Stat3	163,168	ErbB-2	127,133	Stat3	ErbB-2	6774	2064	Gene	Gene	coactivator|nmod|START_ENTITY function|nmod|coactivator function|nsubj|END_ENTITY	Progesterone_receptor induces ErbB-2 nuclear translocation to promote breast_cancer growth via a novel transcriptional effect : ErbB-2 function as a coactivator of Stat3 .
20876300	0	Stat3	163,168	ErbB-2	30,36	Stat3	ErbB-2	6774	2064	Gene	Gene	coactivator|nmod|START_ENTITY function|nmod|coactivator induces|parataxis|function induces|dobj|translocation translocation|compound|END_ENTITY	Progesterone_receptor induces ErbB-2 nuclear translocation to promote breast_cancer growth via a novel transcriptional effect : ErbB-2 function as a coactivator of Stat3 .
26212010	0	Stat3	0,5	ErbB-2	16,22	Stat3	ErbB-2	6774	2064	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression , PDCD4 downregulation and breast_cancer metastasis .
23205673	0	Stat3	35,40	Erk1/2	97,103	Stat3	Erk1/2	20848(Tax:10090)	26417;26413	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	Leukemia_inhibitory_factor-induced Stat3 signaling suppresses fibroblast_growth_factor_1-induced Erk1/2 activation to inhibit the downstream differentiation in mouse embryonic stem cells .
12628925	0	Stat3	53,58	GRIM-19	0,7	Stat3	GRIM-19	20848(Tax:10090)	67184(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	GRIM-19 , a death-regulatory gene product , suppresses Stat3 activity via functional interaction .
23426146	0	Stat3	27,32	GSTP1	0,5	Stat3	GSTP1	6774	2950	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	GSTP1 negatively regulates Stat3 activation in epidermal_growth_factor signaling .
14498832	0	Stat3	15,20	Grb2	0,4	Stat3	Grb2	6774	2885	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling .
19182994	0	Stat3	24,29	Ha-ras	0,6	Stat3	Ha-ras	6774	15461(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell .
10903771	0	Stat3	8,13	IL-10	44,49	Stat3	IL-10	6774	3586	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression .
17404258	0	Stat3	95,100	IL-10	0,5	Stat3	IL-10	6774	3586	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3 .
21949832	0	Stat3	97,102	IL-10	14,19	Stat3	IL-10	25125(Tax:10116)	25325(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY upregulating|dobj|phosphorylation regulates|advcl|upregulating regulates|dobj|suppression suppression|compound|END_ENTITY	Akt regulates IL-10 mediated suppression of TNFa-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation .
25187566	0	Stat3	0,5	IL-10	15,20	Stat3	IL-10	6774	3586	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Stat3 promotes IL-10 expression in lupus_T cells through trans-activation and chromatin remodeling .
15805299	0	Stat3	9,14	IL-13Ralpha2	84,96	Stat3	IL-13Ralpha2	6774	3598	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Aberrant Stat3 signaling by interleukin-4 in malignant_glioma cells : involvement of IL-13Ralpha2 .
24799320	0	Stat3	33,38	IL-17	27,32	Stat3	IL-17	20848(Tax:10090)	16171(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Platelet_factor_4 inhibits IL-17 / Stat3 pathway via upregulation of SOCS3 expression in melanoma .
26188063	0	Stat3	48,53	IL-4	69,73	Stat3	IL-4	20848(Tax:10090)	16189(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells .
12075433	0	Stat3	67,72	IL-6	105,109	Stat3	IL-6	6774	3569	Gene	Gene	Activation|nmod|START_ENTITY -3|nmod|Activation -3|nmod|END_ENTITY	Phosphatidylinositol -LRB- PI -RRB- -3 Kinase Contributes to the Activation of Stat3 in M1 Leukemia Cells Induced by IL-6 .
14523032	0	Stat3	30,35	IL-6	25,29	Stat3	IL-6	6774	3569	Gene	Gene	/|dobj|START_ENTITY /|nsubj|Hepatoprotection Hepatoprotection|nmod|END_ENTITY	Hepatoprotection via the IL-6 / Stat3 pathway .
16732314	0	Stat3	28,33	IL-6	19,23	Stat3	IL-6	6774	3569	Gene	Gene	HS4|compound|START_ENTITY END_ENTITY|nmod|HS4	BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription .
18270592	0	Stat3	65,70	IL-6	50,54	Stat3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|amod|hypovolemic_circulatory_collapse hypovolemic_circulatory_collapse|nmod|END_ENTITY	Prevention of hypovolemic_circulatory_collapse by IL-6 activated Stat3 .
20482858	0	Stat3	43,48	IL-6	11,15	Stat3	IL-6	6774	3569	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic_cancer cells in vitro .
22349830	0	Stat3	40,45	IL-6	35,39	Stat3	IL-6	6774	3569	Gene	Gene	survival|amod|START_ENTITY signaling|nsubj|survival Role|parataxis|signaling Role|nmod|regulation regulation|nmod|END_ENTITY	Role of MMP-2 in the regulation of IL-6 / Stat3 survival signaling via interaction with a5b1 integrin in glioma .
22838736	0	Stat3	41,46	IL-6	28,32	Stat3	IL-6	6774	3569	Gene	Gene	activity|amod|START_ENTITY induced|dobj|activity END_ENTITY|acl|induced	Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma .
24803294	0	Stat3	32,37	IL-6	27,31	Stat3	IL-6	6774	3569	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Andrographolide suppresses IL-6 / Stat3 signaling in peripheral blood mononuclear cells from patients with chronic rhinosinusitis with nasal_polyps .
25997003	0	Stat3	86,91	IL-6	81,85	Stat3	IL-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Anti-Fibrotic Effects of Class I HDAC Inhibitor , Mocetinostat Is Associated with IL-6 / Stat3 Signaling in Ischemic_Heart_Failure .
26327817	0	Stat3	138,143	IL-6	133,137	Stat3	IL-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Initiation|parataxis|Pathway Initiation|nmod|Activation Activation|nmod|END_ENTITY	Defective Initiation of Liver_Regeneration in Osteopontin-Deficient Mice after Partial Hepatectomy due to Insufficient Activation of IL-6 / Stat3 Pathway .
8637711	0	Stat3	82,87	IL-6	31,35	Stat3	IL-6	6774	3569	Gene	Gene	contain|dobj|START_ENTITY contain|nsubj|complexes complexes|nmod|element element|compound|END_ENTITY	IL-6-inducible complexes on an IL-6 response element of the junB promoter contain Stat3 and 36 kDa CRE-like site binding protein -LRB- s -RRB- .
9399641	0	Stat3	18,23	Insulin	0,7	Stat3	Insulin	6774	3630	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Insulin activates Stat3 independently of p21ras-ERK and PI-3K signal transduction .
25548278	0	Stat3	73,78	Interleukin-1b	112,126	Stat3	Interleukin-1b	20848(Tax:10090)	16176(Tax:10090)	Gene	Gene	Independent|compound|START_ENTITY Independent|nmod|END_ENTITY	NLRP3 Protein_Deficiency Exacerbates Hyperoxia-induced Lethality through Stat3 Protein Signaling Independent of Interleukin-1b .
15176047	0	Stat3	94,99	Interleukin-6	0,13	Stat3	Interleukin-6	6774	3569	Gene	Gene	pathway|amod|START_ENTITY induced|nmod|pathway apoptosis|acl|induced protects|nmod|apoptosis protects|nsubj|END_ENTITY	Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway .
22522232	0	Stat3	81,86	Interleukin-6	0,13	Stat3	Interleukin-6	733648(Tax:9823)	100628202	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Interleukin-6 enhances porcine parthenote development in vitro , through the IL-6 / Stat3 signaling pathway .
19962667	0	Stat3	43,48	JAK2	4,8	Stat3	JAK2	6774	3717	Gene	Gene	signaling|amod|START_ENTITY blocks|dobj|signaling blocks|nsubj|AZD1480 AZD1480|compound|END_ENTITY	The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid_tumors .
19118011	0	Stat3	28,33	Jak2	51,55	Stat3	Jak2	20848(Tax:10090)	16452(Tax:10090)	Gene	Gene	Independently|compound|START_ENTITY Independently|nmod|mutations mutations|amod|END_ENTITY	Consistent up-regulation of Stat3 Independently of Jak2 mutations in a new murine model of essential_thrombocythemia .
11064148	0	Stat3	17,22	Leptin	0,6	Stat3	Leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Leptin activates Stat3 , Stat1 and AP-1 in mouse adipose tissue .
24486192	0	Stat3	133,138	Leptin	0,6	Stat3	Leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	signal_transducer_and_activator_3|appos|START_ENTITY Nhlh2|nmod|signal_transducer_and_activator_3 expression|nmod|Nhlh2 regulates|dobj|expression regulates|nsubj|signaling signaling|compound|END_ENTITY	Leptin signaling regulates hypothalamic expression of nescient_helix-loop-helix_2 -LRB- Nhlh2 -RRB- through signal_transducer_and_activator_3 -LRB- Stat3 -RRB- .
8782827	0	Stat3	21,26	Leptin	0,6	Stat3	Leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice .
15343382	0	Stat3	89,94	Nef	0,3	Stat3	Nef	6774	6285	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1 ,2 pathways .
9388184	0	Stat3	23,28	PIAS3	52,57	Stat3	PIAS3	6774	10401	Gene	Gene	signal|amod|START_ENTITY inhibition|nmod|signal transduction|nsubj|inhibition transduction|nmod|END_ENTITY	Specific inhibition of Stat3 signal transduction by PIAS3 .
19759305	0	Stat3	9,14	POMC	29,33	Stat3	POMC	20848(Tax:10090)	18976(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|neurons neurons|compound|END_ENTITY	Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity .
25239565	0	Stat3	102,107	PTEN	67,71	Stat3	PTEN	6774	5728	Gene	Gene	growth|dep|START_ENTITY growth|dep|evidence evidence|nmod|END_ENTITY	miR-17-92 cluster promotes cholangiocarcinoma growth : evidence for PTEN as downstream target and IL-6 / Stat3 as upstream activator .
11594781	0	Stat3	85,90	PTP1D	36,41	Stat3	PTP1D	6774	5781	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin .
19509418	0	Stat3	23,28	PTPN11	43,49	Stat3	PTPN11	6774	5781	Gene	Gene	START_ENTITY|nmod|mutants mutants|compound|END_ENTITY	Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan_syndrome and juvenile_myelomonocytic_leukemia .
25657002	0	Stat3	44,49	Par3	29,33	Stat3	Par3	20848(Tax:10090)	112235(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Loss of the Polarity Protein Par3 Activates Stat3 Signaling via an aPKC/NF-kB/IL -6 Axis in Mouse Mammary Cells .
16098628	0	Stat3	10,15	Pias3	52,57	Stat3	Pias3	6774	10401	Gene	Gene	DNA-binding|compound|START_ENTITY associated|nsubjpass|DNA-binding associated|nmod|expression expression|amod|END_ENTITY	Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis_C cirrhosis .
17563747	0	Stat3	58,63	Pin1	0,4	Stat3	Pin1	6774	5300	Gene	Gene	activity|compound|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity .
24799320	0	Stat3	33,38	Platelet_factor_4	0,17	Stat3	Platelet factor 4	20848(Tax:10090)	56744(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Platelet_factor_4 inhibits IL-17 / Stat3 pathway via upregulation of SOCS3 expression in melanoma .
17283176	0	Stat3	156,161	Protein_kinase_C_epsilon	0,24	Stat3	Protein kinase C epsilon	20848(Tax:10090)	18754(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Protein_kinase_C_epsilon , which sensitizes skin to sun 's UV radiation-induced cutaneous_damage and development of squamous_cell_carcinomas , associates with Stat3 .
17875724	0	Stat3	93,98	Protein_kinase_Cepsilon	0,23	Stat3	Protein kinase Cepsilon	6774	5581	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protein_kinase_Cepsilon interacts with signal_transducers_and_activators_of_transcription_3 -LRB- Stat3 -RRB- , phosphorylates Stat3Ser727 , and regulates its constitutive activation in prostate_cancer .
25335925	0	Stat3	100,105	Pwp1	0,4	Stat3	Pwp1	20848(Tax:10090)	103136(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Required|nmod|Signaling Required|nsubjpass|END_ENTITY	Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells Through Regulating Stat3 Signaling .
24799320	0	Stat3	33,38	SOCS3	67,72	Stat3	SOCS3	20848(Tax:10090)	12702(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|expression expression|nummod|END_ENTITY	Platelet_factor_4 inhibits IL-17 / Stat3 pathway via upregulation of SOCS3 expression in melanoma .
22252296	0	Stat3	0,5	Skp2	24,28	Stat3	Skp2	6774	6502	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Stat3 induces oncogenic Skp2 expression in human cervical_carcinoma cells .
23807222	0	Stat3	51,56	Skp2	79,83	Stat3	Skp2	6774	6502	Gene	Gene	inactivation|nmod|START_ENTITY death|nmod|inactivation death|nmod|END_ENTITY	Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2 .
18799889	0	Stat3	10,15	Socs3	87,92	Stat3	Socs3	20848(Tax:10090)	12702(Tax:10090)	Gene	Gene	Status|nmod|START_ENTITY Status|dep|analysis analysis|nmod|role role|nmod|END_ENTITY	Status of Stat3 in an ovalbumin-induced mouse model of asthma : analysis of the role of Socs3 and IL-6 .
17205581	0	Stat3	58,63	Socs_3	0,6	Stat3	Socs 3	6774	9021	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Socs_3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis .
10523640	0	Stat3	79,84	Src	125,128	Stat3	Src	6774	6714	Gene	Gene	activity|amod|START_ENTITY p38|nmod|activity Requirement|nmod|p38 induced|nsubj|Requirement induced|nmod|oncoprotein oncoprotein|compound|END_ENTITY	Requirement for Ras/Rac1-mediated p38 and c-Jun_N-terminal_kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein .
10815799	0	Stat3	14,19	Src	93,96	Stat3	Src	6774	6714	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|activity activity|compound|END_ENTITY	Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity .
11940572	0	Stat3	17,22	Src	34,37	Stat3	Src	6774	6714	Gene	Gene	alpha|nsubj|START_ENTITY alpha|nmod|manner manner|amod|END_ENTITY	ErbB-2 activates Stat3 alpha in a Src - and JAK2-dependent manner .
16546976	0	Stat3	111,116	Src	21,24	Stat3	Src	6774	6714	Gene	Gene	protein|nummod|START_ENTITY containing|dobj|protein cells|acl|containing apoptosis|nmod|cells signaling|dobj|apoptosis signaling|nsubj|END_ENTITY	Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein .
16871430	0	Stat3	18,23	Src	0,3	Stat3	Src	6774	6714	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic_adenocarcinoma cells .
18314882	0	Stat3	95,100	Src	124,127	Stat3	Src	6774	6714	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Alpha-1 adrenergic receptor transactivates signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- through activation of Src and epidermal_growth_factor_receptor -LRB- EGFR -RRB- in hepatocytes .
9566874	0	Stat3	0,5	Src	20,23	Stat3	Src	20848(Tax:10090)	20779(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Stat3 activation by Src induces specific gene regulation and is required for cell transformation .
22838736	0	Stat3	41,46	Stat1	0,5	Stat3	Stat1	6774	6772	Gene	Gene	activity|amod|START_ENTITY induced|dobj|activity IL-6|acl|induced attenuates|dobj|IL-6 attenuates|nsubj|activation activation|amod|END_ENTITY	Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma .
26392462	0	Stat3	92,97	Stat1	0,5	Stat3	Stat1	20848(Tax:10090)	20846(Tax:10090)	Gene	Gene	Severity|nmod|START_ENTITY Severity|compound|END_ENTITY	Stat1 Regulates Lupus-like Chronic_Graft-versus-Host_Disease Severity via Interactions with Stat3 .
9153303	0	Stat3	11,16	Stat1	142,147	Stat3	Stat1	6774	6772	Gene	Gene	Mapping|nmod|START_ENTITY serine|nsubj|Mapping serine|ccomp|has has|dobj|influence influence|nmod|binding binding|nmod|END_ENTITY	Mapping of Stat3 serine phosphorylation to a single residue -LRB- 727 -RRB- and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3 .
8704168	0	Stat3	47,52	Steel_factor	0,12	Stat3	Steel factor	6774	4254	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Steel_factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines .
8555464	0	Stat3	51,56	Thrombopoietin	0,14	Stat3	Thrombopoietin	6774	7066	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets .
25264029	0	Stat3	94,99	Toll-Like_Receptor_3	48,68	Stat3	Toll-Like Receptor 3	20848(Tax:10090)	142980(Tax:10090)	Gene	Gene	retina|nmod|START_ENTITY role|nmod|retina role|nmod|END_ENTITY	A novel protective role for the innate immunity Toll-Like_Receptor_3 -LRB- TLR3 -RRB- in the retina via Stat3 .
17997399	0	Stat3	68,73	Trps1	0,5	Stat3	Trps1	20848(Tax:10090)	83925(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling .
11960372	0	Stat3	13,18	VEGF	41,45	Stat3	VEGF	6774	7422	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis .
21633597	0	Stat3	76,81	VEGF	40,44	Stat3	VEGF	6774	7422	Gene	Gene	IL-6|nmod|START_ENTITY induced|nmod|IL-6 expression|acl|induced expression|amod|END_ENTITY	-LRB- - -RRB- - Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric_cancer .
25151964	0	Stat3	57,62	VEGF	0,4	Stat3	VEGF	6774	7422	Gene	Gene	drives|nmod|START_ENTITY drives|nsubj|END_ENTITY	VEGF drives cancer-initiating stem cells through VEGFR-2 / Stat3 signaling to upregulate Myc and Sox2 .
26566627	0	Stat3	42,47	VEGF	81,85	Stat3	VEGF	6774	7422	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric_cancer .
23333300	0	Stat3	0,5	WTX	15,18	Stat3	WTX	6774	139285	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms_tumor .
18059167	0	Stat3	14,19	YC-1	32,36	Stat3	YC-1	6774	5937	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular_carcinoma .
8662795	0	Stat3	55,60	acute_phase_response_factor	27,54	Stat3	acute phase response factor	6774	6774	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Differential activation of acute_phase_response_factor / Stat3 and Stat1 via the cytoplasmic domain of the interleukin_6 signal transducer gp130 .
22140473	0	Stat3	0,5	autotaxin	29,38	Stat3	autotaxin	6774	5168	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	Stat3 mediates expression of autotaxin in breast_cancer .
24005672	0	Stat3	131,136	connective_tissue_growth_factor	46,77	Stat3	connective tissue growth factor	6774	1490	Gene	Gene	requires|dobj|START_ENTITY END_ENTITY|acl:relcl|requires	Transforming_growth_factor-b -LRB- TGF-b -RRB- - mediated connective_tissue_growth_factor -LRB- CTGF -RRB- expression in hepatic stellate cells requires Stat3 signaling activation .
14963038	0	Stat3	57,62	epidermal_growth_factor	15,38	Stat3	epidermal growth factor	6774	1950	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Pyk2 amplifies epidermal_growth_factor and c-Src-induced Stat3 activation .
23426146	0	Stat3	27,32	epidermal_growth_factor	47,70	Stat3	epidermal growth factor	6774	1950	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nmod|END_ENTITY	GSTP1 negatively regulates Stat3 activation in epidermal_growth_factor signaling .
8140422	0	Stat3	0,5	epidermal_growth_factor	81,104	Stat3	epidermal growth factor	6774	1950	Gene	Gene	START_ENTITY|dep|member member|acl|activated activated|nmod|END_ENTITY	Stat3 : a STAT family member activated by tyrosine phosphorylation in response to epidermal_growth_factor and interleukin-6 .
14511121	0	Stat3	33,38	gp130	85,90	Stat3	gp130	6774	3572	Gene	Gene	response|amod|START_ENTITY Induction|nmod|response Induction|nmod|cytokines cytokines|amod|END_ENTITY	Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines .
15292206	0	Stat3	60,65	gp130	36,41	Stat3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK .
15466183	0	Stat3	81,86	gp130	14,19	Stat3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY constitutive|dobj|activation constitutive|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of gp130 signaling in breast_cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy .
16041381	0	Stat3	19,24	gp130	28,33	Stat3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling .
19852956	0	Stat3	34,39	gp130	24,29	Stat3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Activated Rac1 requires gp130 for Stat3 activation , cell proliferation and migration .
22268122	0	Stat3	12,17	gp130	81,86	Stat3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	dissociates|nsubj|START_ENTITY dissociates|nmod|emphysema emphysema|nmod|mice mice|amod|END_ENTITY	Deregulated Stat3 signaling dissociates pulmonary_inflammation from emphysema in gp130 mutant mice .
8612579	0	Stat3	118,123	gp130	90,95	Stat3	gp130	20848(Tax:10090)	16195(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY essential|nmod|activation END_ENTITY|acl:relcl|essential	Differentiation and growth_arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation .
14715258	0	Stat3	0,5	heat_shock_27kDa_protein	16,40	Stat3	heat shock 27kDa protein	6774	3315	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Stat3 modulates heat_shock_27kDa_protein expression in breast epithelial cells .
14511121	0	Stat3	33,38	interferon-gamma	16,32	Stat3	interferon-gamma	6774	3458	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines .
15649407	0	Stat3	97,102	interferon-gamma	41,57	Stat3	interferon-gamma	20848(Tax:10090)	15978(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediated|nmod|activation mediated|nsubjpass|induction induction|nmod|SOCS-3 SOCS-3|nmod|END_ENTITY	Stat1-independent induction of SOCS-3 by interferon-gamma is mediated by sustained activation of Stat3 in mouse embryonic fibroblasts .
16332928	0	Stat3	20,25	interferon-gamma	62,78	Stat3	interferon-gamma	6774	3458	Gene	Gene	role|nmod|START_ENTITY Distinctive|dobj|role activation|dep|Distinctive activation|acl|mediating mediating|dobj|inhibition inhibition|amod|END_ENTITY	Distinctive role of Stat3 and Erk-1 / 2 activation in mediating interferon-gamma inhibition of TGF-beta1 action .
7488223	0	Stat3	66,71	interferon-gamma	87,103	Stat3	interferon-gamma	6774	3458	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- expression by interferon-gamma and interleukin-6 in hepatoma cells .
15805299	0	Stat3	9,14	interleukin-4	28,41	Stat3	interleukin-4	6774	3565	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Aberrant Stat3 signaling by interleukin-4 in malignant_glioma cells : involvement of IL-13Ralpha2 .
11807001	0	Stat3	112,117	interleukin-5	12,25	Stat3	interleukin-5	6774	3567	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|production production|amod|END_ENTITY	Spontaneous interleukin-5 production in cutaneous_T-cell_lymphoma lines is mediated by constitutively activated Stat3 .
10636920	0	Stat3	18,23	interleukin-6	77,90	Stat3	interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY required|nsubjpass|Activation required|nmod|END_ENTITY	Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells .
10845908	0	Stat3	13,18	interleukin-6	124,137	Stat3	interleukin-6	6774	3569	Gene	Gene	caused|nsubj|START_ENTITY caused|nmod|secretion secretion|nmod|END_ENTITY	Constitutive Stat3 , Tyr705 , and Ser727 phosphorylation in acute_myeloid_leukemia cells caused by the autocrine secretion of interleukin-6 .
15998296	0	Stat3	105,110	interleukin-6	12,25	Stat3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY involvement|nmod|activation aggravates|parataxis|involvement aggravates|nsubj|Blockade Blockade|nmod|signaling signaling|amod|END_ENTITY	Blockade of interleukin-6 signaling aggravates ischemic_cerebral_damage in mice : possible involvement of Stat3 activation in the protection of neurons .
16887796	0	Stat3	0,5	interleukin-6	15,28	Stat3	interleukin-6	6774	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|correction correction|amod|END_ENTITY	Stat3 mediates interleukin-6 -LSB- correction of interelukin-6 -RSB- inhibition of human endothelial_nitric-oxide_synthase expression .
19437447	0	Stat3	33,38	interleukin-6	19,32	Stat3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	anti-apoptotic|amod|START_ENTITY link|dep|anti-apoptotic link|nmod|END_ENTITY	A link between the interleukin-6 / Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos .
21211286	0	Stat3	44,49	interleukin-6	30,43	Stat3	interleukin-6	6774	3569	Gene	Gene	signaling|nsubj|START_ENTITY Effects|parataxis|signaling Effects|nmod|END_ENTITY	-LSB- Effects of siltuximab on the interleukin-6 / Stat3 signaling pathway in ovarian_cancer -RSB- .
22684844	0	Stat3	69,74	interleukin-6	24,37	Stat3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	dissociates|dobj|START_ENTITY dissociates|nsubj|partitioning partitioning|nmod|signalling signalling|amod|END_ENTITY	Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung_fibrosis .
8662645	0	Stat3	80,85	interleukin-6	34,47	Stat3	interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY accompanied|nmod|activation accompanied|nsubjpass|Induction Induction|nmod|outgrowth outgrowth|nmod|END_ENTITY	Induction of neurite outgrowth by interleukin-6 is accompanied by activation of Stat3 signaling pathway in a variant PC12 cell -LRB- E2 -RRB- line .
10447634	0	Stat3	37,42	interleukin_6	61,74	Stat3	interleukin 6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Rapid and simultaneous activation of Stat3 and production of interleukin_6 in resuscitated hemorrhagic_shock .
23295202	0	Stat3	0,5	leptin	43,49	Stat3	leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|roles roles|nmod|END_ENTITY	Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol_regulatory_element_binding_protein-1c expression of rat hepatic stellate cells .
24455684	0	Stat3	0,5	leucine-rich_repeat-containing_g_protein-coupled_receptor_4	18,77	Stat3	leucine-rich repeat-containing g protein-coupled receptor 4	6774	55366	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Stat3 upregulates leucine-rich_repeat-containing_g_protein-coupled_receptor_4 expression in osteosarcoma cells .
17925034	0	Stat3	29,34	leukemia_inhibitory_factor	59,85	Stat3	leukemia inhibitory factor	6774	3976	Gene	Gene	activation|amod|START_ENTITY signaling|nsubj|activation signaling|dep|dependent dependent|nmod|END_ENTITY	Mouse mammary_tumors display Stat3 activation dependent on leukemia_inhibitory_factor signaling .
20959490	0	Stat3	121,126	leukemia_inhibitory_factor	158,184	Stat3	leukemia inhibitory factor	20848(Tax:10090)	16878(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|dep|induced induced|nmod|END_ENTITY	Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia_inhibitory_factor .
26175849	0	Stat3	86,91	miR-29b	28,35	Stat3	miR-29b	6774	407024	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Special suppressive role of miR-29b in HER2-positive breast cancer cells by targeting Stat3 .
17922140	0	Stat3	0,5	nicotinamide_N-methyltransferase	33,65	Stat3	nicotinamide N-methyltransferase	6774	4837	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stat3 up-regulates expression of nicotinamide_N-methyltransferase in human cancer cells .
10523640	0	Stat3	79,84	p38	34,37	Stat3	p38	6774	1432	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Requirement for Ras/Rac1-mediated p38 and c-Jun_N-terminal_kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein .
12082540	0	Stat3	14,19	p53	0,3	Stat3	p53	6774	7157	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate_cancer cells expressing constitutively active Stat3 .
19574718	0	Stat3	3,8	p53	16,19	Stat3	p53	6774	7157	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Is Stat3 and/or p53 mRNA expression a prognostic marker for renal_cell_carcinoma ?
7488223	0	Stat3	66,71	signal_transducer_and_activator_of_transcription-3	14,64	Stat3	signal transducer and activator of transcription-3	6774	6774	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- expression by interferon-gamma and interleukin-6 in hepatoma cells .
20063378	0	Stat3	66,71	signal_transducer_and_activator_of_transcription_3	14,64	Stat3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription_3 -LRB- Stat3 -RRB- pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis .
17952632	0	Stat3	43,48	urocortin	62,71	Stat3	urocortin	6774	7349	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Unexpected amplification of leptin-induced Stat3 signaling by urocortin : implications for obesity .
14712222	0	Stat3	0,5	vimentin	15,23	Stat3	vimentin	6774	7431	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein , ZBP-89 .
12540779	0	Stat4	0,5	HO-1	74,78	Stat4	HO-1	20849(Tax:10090)	15368(Tax:10090)	Gene	Gene	START_ENTITY|dep|dependence dependence|compound|END_ENTITY	Stat4 and Stat6 signaling in hepatic_ischemia / reperfusion injury in mice : HO-1 dependence of Stat4 disruption-mediated cytoprotection .
10644731	0	Stat4	15,20	Stat2	84,89	Stat4	Stat2	6775	6773	Gene	Gene	Recruitment|nmod|START_ENTITY requires|nsubj|Recruitment requires|dobj|END_ENTITY	Recruitment of Stat4 to the human interferon-alpha/beta receptor requires activated Stat2 .
20849614	0	Stat5	20,25	Akt	0,3	Stat5	Akt	20850(Tax:10090)	11651(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Akt is required for Stat5 activation and mammary differentiation .
9602424	0	Stat5	25,30	Angiotensin_II	0,14	Stat5	Angiotensin II	24918(Tax:10116)	24179(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Angiotensin_II activates Stat5 through Jak2 kinase in cardiac myocytes .
11756417	0	Stat5	56,61	Bcl-xL	25,31	Stat5	Bcl-xL	6776	598	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways .
12483533	0	Stat5	84,89	Bcr-Abl	14,21	Stat5	Bcr-Abl	6776	25	Gene	Gene	activation|nmod|START_ENTITY constitutive|dobj|activation constitutive|nsubj|Inhibition Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells .
25809097	0	Stat5	0,5	Bcr-Abl	71,78	Stat5	Bcr-Abl	6776	25	Gene	Gene	Distinct|compound|START_ENTITY Distinct|appos|Functions Functions|nmod|K562 K562|compound|END_ENTITY	Stat5 Exerts Distinct , Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl + K562 and Jak2 -LRB- V617F -RRB- + HEL_Leukemia Cells .
12879454	0	Stat5	20,25	Bcr/Abl	80,87	Stat5	Bcr/Abl	6776	25	Gene	Gene	Immunoreactivity|nmod|START_ENTITY phosphorylated|nsubj|Immunoreactivity phosphorylated|nmod|measure measure|nmod|activity activity|compound|END_ENTITY	Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity .
10428780	0	Stat5	61,66	Erythropoietin	0,14	Stat5	Erythropoietin	6776	2056	Gene	Gene	induce|nmod|START_ENTITY induce|nsubj|END_ENTITY	Erythropoietin can induce the expression of bcl-x -LRB- L -RRB- through Stat5 in erythropoietin-dependent progenitor cell lines .
11152572	0	Stat5	45,50	Erythropoietin	0,14	Stat5	Erythropoietin	6776	2056	Gene	Gene	signal|nmod|START_ENTITY receptors|acl:relcl|signal receptors|compound|END_ENTITY	Erythropoietin receptors that signal through Stat5 or Stat3 support fetal liver and adult erythropoiesis : lack of specificity of stat signals during red blood cell development .
8657137	0	Stat5	37,42	Erythropoietin	0,14	Stat5	Erythropoietin	6776	2056	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response .
25456130	0	Stat5	14,19	FLT3	49,53	Stat5	FLT3	20850(Tax:10090)	14255(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3 - and KIT-Driven Leukemogenesis .
24298014	0	Stat5	67,72	Foxp3	15,20	Stat5	Foxp3	6776	50943	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	TGF-b-mediated Foxp3 gene expression is cooperatively regulated by Stat5 , Creb , and AP-1 through CNS2 .
10679091	0	Stat5	142,147	IL-2	4,8	Stat5	IL-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY promotes|nmod|domain promotes|nsubj|receptor receptor|compound|END_ENTITY	The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc , bcl-2 , and bcl-x genes through the trans-activation domain of Stat5 .
11160217	0	Stat5	0,5	IL-2	74,78	Stat5	IL-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Stat5 and Sp1 regulate transcription of the cyclin_D2 gene in response to IL-2 .
11784295	0	Stat5	26,31	IL-2	47,51	Stat5	IL-2	6776	3558	Gene	Gene	DNA-binding|compound|START_ENTITY DNA-binding|nmod|END_ENTITY	Interferon-alpha inhibits Stat5 DNA-binding in IL-2 stimulated primary T-lymphocytes .
12407017	0	Stat5	26,31	IL-2	72,76	Stat5	IL-2	6776	3558	Gene	Gene	proteins|amod|START_ENTITY phosphorylation|nmod|proteins stimulated|nsubj|phosphorylation stimulated|nmod|END_ENTITY	Serine phosphorylation of Stat5 proteins in lymphocytes stimulated with IL-2 .
23395551	0	Stat5	106,111	IL-2	101,105	Stat5	IL-2	20850(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|amod|autoimmune_T_cell-driven_retinal_disease autoimmune_T_cell-driven_retinal_disease|nmod|mice mice|nmod|inhibition inhibition|nmod|/ /|compound|END_ENTITY	SIRT1 activation protects against autoimmune_T_cell-driven_retinal_disease in mice via inhibition of IL-2 / Stat5 signaling .
8896456	0	Stat5	107,112	IL-2	3,7	Stat5	IL-2	6776	3558	Gene	Gene	binds|dobj|START_ENTITY element|acl:relcl|binds element|nsubj|element element|compound|END_ENTITY	An IL-2 response element in the human IL-2_receptor_alpha chain promoter is a composite element that binds Stat5 , Elf-1 , HMG-I -LRB- Y -RRB- and a GATA family protein .
9989503	0	Stat5	35,40	IL-2	54,58	Stat5	IL-2	6776	3558	Gene	Gene	association|nmod|START_ENTITY association|nmod|signaling signaling|amod|END_ENTITY	Functional association of Nmi with Stat5 and Stat1 in IL-2 - and IFNgamma-mediated signaling .
11728342	0	Stat5	70,75	IL-7_receptor	4,17	Stat5	IL-7 receptor	20850(Tax:10090)	16197(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	The IL-7_receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation .
12377952	0	Stat5	85,90	Interleukin-2	0,13	Stat5	Interleukin-2	6776	3558	Gene	Gene	factors|amod|START_ENTITY motif|nmod|factors phosphorylation|nmod|motif stimulate|dobj|phosphorylation stimulate|nsubj|cytokines cytokines|amod|END_ENTITY	Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells : resistance to suppression of multiple serine kinase pathways .
21941370	0	Stat5	63,68	JAK2	27,31	Stat5	JAK2	20850(Tax:10090)	16452(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY elevates|dobj|signalling elevates|nsubj|activation activation|nmod|END_ENTITY	Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling , promotes alveologenesis and resistance to cell death , and contributes to tumourigenesis .
8702638	0	Stat5	108,113	Jak2	36,40	Stat5	Jak2	6776	3717	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation tyrosine|ccomp|induces tyrosine|nsubj|END_ENTITY	An epidermal_growth_factor_receptor / Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cells .
9602424	0	Stat5	25,30	Jak2	39,43	Stat5	Jak2	24918(Tax:10116)	24514(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|kinase kinase|amod|END_ENTITY	Angiotensin_II activates Stat5 through Jak2 kinase in cardiac myocytes .
9989503	0	Stat5	35,40	Nmi	26,29	Stat5	Nmi	6776	9111	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Functional association of Nmi with Stat5 and Stat1 in IL-2 - and IFNgamma-mediated signaling .
11133161	0	Stat5	64,69	Prolactin	0,9	Stat5	Prolactin	20850(Tax:10090)	19109(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Prolactin , growth_hormone , and epidermal_growth_factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects .
12060651	0	Stat5	41,46	Prolactin	0,9	Stat5	Prolactin	6776	5617	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Prolactin induces SHP-2 association with Stat5 , nuclear translocation , and binding to the beta-casein gene promoter in mammary cells .
15885880	0	Stat5	22,27	Prolactin	0,9	Stat5	Prolactin	6776	5617	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Prolactin signals via Stat5 and Oct-1 to the proximal cyclin_D1 promoter .
7925280	0	Stat5	47,52	Prolactin	0,9	Stat5	Prolactin	6776	5617	Gene	Gene	Tyr694|nmod|START_ENTITY phosphorylation|nmod|Tyr694 induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Prolactin induces phosphorylation of Tyr694 of Stat5 -LRB- MGF -RRB- , a prerequisite for DNA binding and induction of transcription .
9516478	0	Stat5	29,34	Prolactin_receptor	0,18	Stat5	Prolactin receptor	6776	5618	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Prolactin_receptor regulates Stat5 tyrosine phosphorylation and nuclear translocation by two separate pathways .
16959766	0	Stat5	109,114	Shp2	24,28	Stat5	Shp2	6776	5781	Gene	Gene	activation|compound|START_ENTITY leads|nmod|activation leads|nsubj|deletion deletion|nmod|END_ENTITY	Conditional deletion of Shp2 in the mammary gland leads to impaired_lobulo-alveolar_outgrowth and attenuated Stat5 activation .
11042182	1	Stat5	119,124	Stem_cell_factor	76,92	Stat5	Stem cell factor	20850(Tax:10090)	17311(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Stem_cell_factor induces the expression of Stat5 and erythropoietin_receptor , resulting in efficient proliferation and survival by erythropoietin .
9600081	0	Stat5	117,122	TPO	131,134	Stat5	TPO	6776	7173	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Thrombopoietin induces tyrosine phosphorylation of a common beta subunit of GM-CSF receptor and its association with Stat5 in TF-1 / TPO cells .
11756417	0	Stat5	56,61	Thrombopoietin	0,14	Stat5	Thrombopoietin	6776	7066	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways .
18172316	0	Stat5	21,26	androgen_receptor	43,60	Stat5	androgen receptor	6776	367	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Transcription factor Stat5 synergizes with androgen_receptor in prostate_cancer cells .
21216933	0	Stat5	21,26	androgen_receptor	46,63	Stat5	androgen receptor	6776	367	Gene	Gene	knockdown|compound|START_ENTITY enhances|nsubj|knockdown enhances|dobj|degradation degradation|compound|END_ENTITY	Transcription factor Stat5 knockdown enhances androgen_receptor degradation and delays castration-resistant prostate_cancer progression in vivo .
15062567	0	Stat5	77,82	erythropoietin	10,24	Stat5	erythropoietin	24918(Tax:10116)	24335(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY activation|nmod|pathway associated|nmod|activation associated|nsubjpass|Effect Effect|nmod|END_ENTITY	Effect of erythropoietin on Leydig cell is associated with the activation of Stat5 pathway .
8977232	0	Stat5	45,50	erythropoietin	97,111	Stat5	erythropoietin	6776	2056	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3 .
11042034	0	Stat5	27,32	granulocyte_colony-stimulating_factor	55,92	Stat5	granulocyte colony-stimulating factor	6776	1440	Gene	Gene	isoforms|amod|START_ENTITY Delineation|nmod|isoforms activated|nsubj|Delineation activated|nmod|END_ENTITY	Delineation and mapping of Stat5 isoforms activated by granulocyte_colony-stimulating_factor in myeloid cells .
9122188	0	Stat5	0,5	insulin_receptor	42,58	Stat5	insulin receptor	20850(Tax:10090)	16337(Tax:10090)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Stat5 is a physiological substrate of the insulin_receptor .
12231477	0	Stat5	163,168	interleukin-2	69,82	Stat5	interleukin-2	6776	3558	Gene	Gene	sites|amod|START_ENTITY region|nmod|sites role|nmod|region Induction|dep|role Induction|nmod|expression expression|nmod|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
11311850	0	Stat5a	76,82	Growth_hormone	0,14	Stat5a	Growth hormone	6776	2688	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Growth_hormone induces tyrosyl phosphorylation of the transcription factors Stat5a and Stat5b in CMT-U335 canine mammary_tumor cells .
9390692	0	Stat5a	22,28	Stat5a	80,86	Stat5a	Stat5a	20850(Tax:10090)	20850(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	An indirect effect of Stat5a in IL-2-induced proliferation : a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction .
9390692	0	Stat5a	80,86	Stat5a	22,28	Stat5a	Stat5a	20850(Tax:10090)	20850(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	An indirect effect of Stat5a in IL-2-induced proliferation : a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction .
10350046	0	Stat5b	31,37	MEK	0,3	Stat5b	MEK	6777	5609	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MEK is a negative regulator of Stat5b in PDGF-stimulated cells .
12682066	0	Stat5b	91,97	growth_hormone	68,82	Stat5b	growth hormone	20851(Tax:10090)	14599(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Acute control of insulin-like_growth_factor-I gene transcription by growth_hormone through Stat5b .
16303763	0	Stat5b	29,35	growth_hormone	43,57	Stat5b	growth hormone	6777	2688	Gene	Gene	folding|nmod|START_ENTITY causes|nsubj|folding causes|dobj|insensitivity_and_proteasomal_dysfunction insensitivity_and_proteasomal_dysfunction|amod|END_ENTITY	Aberrant folding of a mutant Stat5b causes growth_hormone insensitivity_and_proteasomal_dysfunction .
12682066	0	Stat5b	91,97	insulin-like_growth_factor-I	17,45	Stat5b	insulin-like growth factor-I	20851(Tax:10090)	16000(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|control control|nmod|gene gene|compound|END_ENTITY	Acute control of insulin-like_growth_factor-I gene transcription by growth_hormone through Stat5b .
11682625	0	Stat5b	132,138	signal_transducer_and_activator_of_transcription_5b	79,130	Stat5b	signal transducer and activator of transcription 5b	25126(Tax:10116)	25126(Tax:10116)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	PRL-induced ERalpha gene expression is mediated by Janus_kinase_2 -LRB- Jak2 -RRB- while signal_transducer_and_activator_of_transcription_5b -LRB- Stat5b -RRB- phosphorylation involves Jak2 and a second tyrosine kinase .
10549628	0	Stat6	100,105	CD4	13,16	Stat6	CD4	6778	920	Gene	Gene	T|dep|START_ENTITY T|compound|END_ENTITY	Autoreactive CD4 + T cells protect from autoimmune diabetes via bystander suppression using the IL-4 / Stat6 pathway .
10490982	0	Stat6	20,25	IFN-alpha	0,9	Stat6	IFN-alpha	6778	3439	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	IFN-alpha activates Stat6 and leads to the formation of Stat2 : Stat6 complexes in B cells .
10549628	0	Stat6	100,105	IL-4	95,99	Stat6	IL-4	6778	3565	Gene	Gene	T|dep|START_ENTITY T|acl:relcl|protect protect|xcomp|using using|dobj|END_ENTITY	Autoreactive CD4 + T cells protect from autoimmune diabetes via bystander suppression using the IL-4 / Stat6 pathway .
10679064	0	Stat6	0,5	IL-4	28,32	Stat6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|responses responses|compound|END_ENTITY	Stat6 regulation of in vivo IL-4 responses .
11390477	0	Stat6	0,5	IL-4	38,42	Stat6	IL-4	6778	3565	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|role role|nmod:poss|END_ENTITY	Stat6 is necessary and sufficient for IL-4 's role in Th2 differentiation and cell expansion .
11739727	0	Stat6	0,5	IL-4	44,48	Stat6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|interleukin_4 interleukin_4|appos|END_ENTITY	Stat6 and IRS-2 cooperate in interleukin_4 -LRB- IL-4 -RRB- - induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis .
12847266	0	Stat6	118,123	IL-4	14,18	Stat6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	nerves|amod|START_ENTITY contractility|nmod|nerves Dependence|nmod|contractility Dependence|nmod|END_ENTITY	Dependence of IL-4 , IL-13 , and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves .
12902491	0	Stat6	75,80	IL-4	19,23	Stat6	IL-4	6778	3565	Gene	Gene	induction|amod|START_ENTITY mediated|nsubj|induction signal|parataxis|mediated signal|nsubj|programming programming|nmod|receptor receptor|compound|END_ENTITY	New programming of IL-4 receptor signal transduction in activated T cells : Stat6 induction and Th2 differentiation mediated by IL-4Ralpha lacking cytoplasmic tyrosines .
16298365	0	Stat6	98,103	IL-4	0,4	Stat6	IL-4	6778	3565	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	IL-4 modulates the histamine content of mast cells in a mast cell/fibroblast co-culture through a Stat6 signaling pathway in fibroblasts .
18292582	0	Stat6	111,116	IL-4	0,4	Stat6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	initiated|nmod|START_ENTITY allergic_inflammation|acl|initiated generation|nmod|allergic_inflammation determinant|nmod|generation determinant|nsubj|END_ENTITY	IL-4 is a critical determinant in the generation of allergic_inflammation initiated by a constitutively active Stat6 .
18294957	0	Stat6	5,10	IL-4	0,4	Stat6	IL-4	6778	3565	Gene	Gene	activities|amod|START_ENTITY correlate|nsubj|activities END_ENTITY|appos|correlate	IL-4 / Stat6 activities correlate with apoptosis and metastasis in colon_cancer cells .
18536936	0	Stat6	18,23	IL-4	13,17	Stat6	IL-4	6778	3565	Gene	Gene	activities|amod|START_ENTITY correlate|nsubj|activities END_ENTITY|parataxis|correlate	Differential IL-4 / Stat6 activities correlate with differential expression of regulatory genes SOCS-1 , SHP-1 , and PP2A in colon_cancer cells .
7760829	0	Stat6	18,23	IL-4	104,108	Stat6	IL-4	20852(Tax:10090)	3565	Gene	Gene	Cloning|nmod|START_ENTITY phosphorylated|advcl|Cloning phosphorylated|nmod|END_ENTITY	Cloning of murine Stat6 and human Stat6 , Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis .
8602263	0	Stat6	18,23	IL-4	27,31	Stat6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|signalling signalling|compound|END_ENTITY	Essential role of Stat6 in IL-4 signalling .
8624821	0	Stat6	0,5	IL-4	45,49	Stat6	IL-4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|advcl|mediating mediating|nmod|END_ENTITY	Stat6 is required for mediating responses to IL-4 and for development of Th2 cells .
24943510	0	Stat6	160,165	Interleukin-4	0,13	Stat6	Interleukin-4	6778	3565	Gene	Gene	the|nmod|START_ENTITY involves|dobj|the involves|nsubj|up-regulation up-regulation|amod|END_ENTITY	Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal_transducer_and_activator_of_transcription_6 -LRB- Stat6 -RRB- to the imperfect Stat6 sites .
24943510	0	Stat6	184,189	Interleukin-4	0,13	Stat6	Interleukin-4	6778	3565	Gene	Gene	sites|amod|START_ENTITY Stat6|nmod|sites the|nmod|Stat6 involves|dobj|the involves|nsubj|up-regulation up-regulation|amod|END_ENTITY	Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal_transducer_and_activator_of_transcription_6 -LRB- Stat6 -RRB- to the imperfect Stat6 sites .
26918372	0	Stat6	96,101	Interleukin-4	0,13	Stat6	Interleukin-4	6778	3565	Gene	Gene	Sequestration|compound|START_ENTITY Downregulation|nmod|Sequestration Downregulation|compound|END_ENTITY	Interleukin-4 Downregulation of Involucrin Expression in Human Epidermal Keratinocytes Involves Stat6 Sequestration of the Coactivator CREB-Binding_Protein .
18536936	0	Stat6	18,23	SOCS-1	94,100	Stat6	SOCS-1	6778	8651	Gene	Gene	activities|amod|START_ENTITY correlate|nsubj|activities correlate|nmod|END_ENTITY	Differential IL-4 / Stat6 activities correlate with differential expression of regulatory genes SOCS-1 , SHP-1 , and PP2A in colon_cancer cells .
19551406	0	Stat6	53,58	SOCS-1	76,82	Stat6	SOCS-1	6778	8651	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon_cancer cells .
23184467	0	Stat6	0,5	Sp1	22,25	Stat6	Sp1	6778	6667	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Stat6 cooperates with Sp1 in controlling breast_cancer cell proliferation by modulating the expression of p21 -LRB- Cip1/WAF1 -RRB- and p27 -LRB- Kip1 -RRB- .
8602264	0	Stat6	81,86	Th2	21,24	Stat6	Th2	20852(Tax:10090)	15111(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY disrupted|dobj|gene disrupted|nsubj|Lack Lack|nmod|response response|compound|END_ENTITY	Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene .
11944890	0	Stat6	52,57	VCAM-1	76,82	Stat6	VCAM-1	6778	7412	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1 .
10364072	0	Stat6	0,5	interleukin-4	34,47	Stat6	interleukin-4	6778	3565	Gene	Gene	activation|amod|START_ENTITY essential|nsubj|activation essential|nmod|induction induction|compound|END_ENTITY	Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells .
10373589	0	Stat6	87,92	interleukin-4	54,67	Stat6	interleukin-4	6778	3565	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6 .
19929568	0	Stat6	24,29	interleukin-4	10,23	Stat6	interleukin-4	6778	3565	Gene	Gene	activity|amod|START_ENTITY correlates|nsubj|activity END_ENTITY|parataxis|correlates	Defective interleukin-4 / Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3 , SOCS-7 , and CISH in colon_cancer cells .
9845517	0	Stat6	0,5	interleukin-4	21,34	Stat6	interleukin-4	6778	3565	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Stat6 inhibits human interleukin-4 promoter activity in T cells .
11739727	0	Stat6	0,5	interleukin_4	29,42	Stat6	interleukin 4	20852(Tax:10090)	16189(Tax:10090)	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Stat6 and IRS-2 cooperate in interleukin_4 -LRB- IL-4 -RRB- - induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis .
8621467	0	Stat_1	29,35	Growth_hormone	0,14	Stat 1	Growth hormone	25124(Tax:10116)	81668(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Growth_hormone activation of Stat_1 , Stat_3 , and Stat_5 in rat liver .
12707028	0	Stat_3	64,70	signal_transducer_and_activator_of_transcription_3	12,62	Stat 3	signal transducer and activator of transcription 3	6774	6774	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Analysis of signal_transducer_and_activator_of_transcription_3 -LRB- Stat_3 -RRB- pathway in multiple_myeloma : Stat_3 activation and cyclin_D1 dysregulation are mutually exclusive events .
7538664	0	Stat_5	90,96	Epidermal_growth_factor	0,23	Stat 5	Epidermal growth factor	20850(Tax:10090)	13645(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces the tyrosine phosphorylation and nuclear translocation of Stat_5 in mouse liver .
10830280	0	Stat_5B	0,7	insulin	22,29	Stat 5B	insulin	6777	3630	Gene	Gene	START_ENTITY|acl|activated activated|nmod|END_ENTITY	Stat_5B , activated by insulin in a Jak-independent fashion , plays a role in glucokinase gene transcription .
9428692	0	Stat_5B	18,25	insulin_receptor	48,64	Stat 5B	insulin receptor	6777	3643	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Stat_5B as a substrate of the insulin_receptor .
26661905	0	Stathmin_1	47,57	epidermal_growth_factor_receptor	4,36	Stathmin 1	epidermal growth factor receptor	16765(Tax:10090)	13649(Tax:10090)	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	The epidermal_growth_factor_receptor decreases Stathmin_1 and triggers catagen entry in the mouse .
25967354	0	Stature_Homeobox-Containing	45,72	SHOX	74,78	Stature Homeobox-Containing	SHOX	6473	6473	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Radiological Features in Patients with Short Stature_Homeobox-Containing -LRB- SHOX -RRB- Gene Deficiency_and_Turner_Syndrome before and after 2 Years of GH Treatment .
22166206	0	Stau1	0,5	Dvl2	16,20	Stau1	Dvl2	6780	1856	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Stau1 regulates Dvl2 expression during myoblast differentiation .
12843282	0	Staufen	115,122	Barentsz	0,8	Staufen	Barentsz	37065(Tax:7227)	22794	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Barentsz , a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells , interacts with Staufen in an RNA-dependent manner .
19563796	0	Stbm/Vang	83,92	Scribble	38,46	Stbm/Vang	Scribble	35922(Tax:7227)	44448(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors .
22869728	0	Stch	30,34	Hspa13	22,28	Stch	Hspa13	110920(Tax:10090)	110920(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Overexpression of the Hspa13 -LRB- Stch -RRB- gene reduces prion_disease incubation time in mice .
15327964	0	Ste11	43,48	Ste50	92,97	Ste11	Ste50	851076(Tax:4932)	850325(Tax:4932)	Gene	Gene	domain|compound|START_ENTITY structure|nmod|domain structure|nmod|END_ENTITY	The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50 .
16337230	0	Ste11	48,53	Ste50	25,30	Ste11	Ste50	851076(Tax:4932)	850325(Tax:4932)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Saccharomyces_cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction .
16428446	0	Ste11	67,72	Ste50	17,22	Ste11	Ste50	851076(Tax:4932)	850325(Tax:4932)	Gene	Gene	delivery|nmod|START_ENTITY required|nmod|delivery required|nsubjpass|domain domain|nmod|protein protein|amod|END_ENTITY	The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces_cerevisiae .
16337592	0	Ste20	23,28	MINK	15,19	Ste20	MINK	8428	50488	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|appos|kinase	Involvement of MINK , a Ste20 family kinase , in Ras oncogene-induced growth_arrest in human_ovarian_surface_epithelial cells .
12151406	0	Ste20-like_kinase	19,36	SLK	38,41	Ste20-like kinase	SLK	9748	9748	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of the Ste20-like_kinase -LRB- SLK -RRB- with the microtubule .
17003224	0	Ste20-like_kinase	34,51	SLK	52,55	Ste20-like kinase	SLK	9748	9748	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The 3 ' - untranslated region of the Ste20-like_kinase SLK regulates SLK expression .
17003224	0	Ste20-like_kinase	34,51	SLK	66,69	Ste20-like kinase	SLK	9748	9748	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The 3 ' - untranslated region of the Ste20-like_kinase SLK regulates SLK expression .
15657049	0	Ste5	57,61	Cdc24	0,5	Ste5	Cdc24	851680(Tax:4932)	851190(Tax:4932)	Gene	Gene	shuttling|nmod|START_ENTITY regulates|dobj|shuttling regulates|nsubj|END_ENTITY	Cdc24 regulates nuclear shuttling and recruitment of the Ste5 scaffold to a heterotrimeric G protein in Saccharomyces_cerevisiae .
15327964	0	Ste50	92,97	Ste11	43,48	Ste50	Ste11	850325(Tax:4932)	851076(Tax:4932)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|domain domain|compound|END_ENTITY	The solution structure of the S.cerevisiae Ste11 MAPKKK SAM domain and its partnership with Ste50 .
16337230	0	Ste50	25,30	Ste11	48,53	Ste50	Ste11	850325(Tax:4932)	851076(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Saccharomyces_cerevisiae Ste50 binds the MAPKKK Ste11 through a head-to-tail SAM domain interaction .
16428446	0	Ste50	17,22	Ste11	67,72	Ste50	Ste11	850325(Tax:4932)	851076(Tax:4932)	Gene	Gene	protein|amod|START_ENTITY domain|nmod|protein required|nsubjpass|domain required|nmod|delivery delivery|nmod|END_ENTITY	The RA domain of Ste50 adaptor protein is required for delivery of Ste11 to the plasma membrane in the filamentous growth signaling pathway of the yeast Saccharomyces_cerevisiae .
8668180	0	Ste7	187,191	Kss1	137,141	Ste7	Kss1	851396(Tax:4932)	852931(Tax:4932)	Gene	Gene	kinases|nmod|START_ENTITY kinases|dobj|END_ENTITY	Signaling in the yeast pheromone response pathway : specific and high-affinity interaction of the mitogen-activated protein -LRB- MAP -RRB- kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7 .
25049903	0	Stearoyl-CoA_Desaturase	18,41	SCD	43,46	Stearoyl-CoA Desaturase	SCD	280924(Tax:9913)	280924(Tax:9913)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Identification of Stearoyl-CoA_Desaturase -LRB- SCD -RRB- Gene Interactions in Korean Native Cattle Based on the Multifactor-dimensionality Reduction Method .
26989730	0	Stearoyl-CoA_Desaturase	37,60	SCD	62,65	Stearoyl-CoA Desaturase	SCD	443185(Tax:9940)	443185(Tax:9940)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	An evolutionary relationship between Stearoyl-CoA_Desaturase -LRB- SCD -RRB- protein sequences involved in fatty_acid metabolism .
20628806	0	Stearoyl-CoA_desaturase	0,23	SCD	25,28	Stearoyl-CoA desaturase	SCD	100860763	100860763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Stearoyl-CoA_desaturase -LRB- SCD -RRB- gene polymorphism in goat breeds .
23139775	0	Stearoyl-CoA_desaturase-1	21,46	SCD1	48,52	Stearoyl-CoA desaturase-1	SCD1	6319	6319	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Heterogeneity of the Stearoyl-CoA_desaturase-1 -LRB- SCD1 -RRB- gene and metabolic risk factors in the EPIC-Potsdam study .
12419843	0	Stearoyl-CoA_desaturase_1	0,25	Scd1	27,31	Stearoyl-CoA desaturase 1	Scd1	20249(Tax:10090)	20249(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Stearoyl-CoA_desaturase_1 -LRB- Scd1 -RRB- gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats .
9092574	0	Steel_factor	0,12	CRKL	49,53	Steel factor	CRKL	4254	1399	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
9092574	0	Steel_factor	0,12	CRKL	69,73	Steel factor	CRKL	4254	1399	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Steel_factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit , phosphatidylinositol 3-kinase , and p120 -LRB- CBL -RRB- .
19494314	0	Steel_factor	0,12	IL-6	51,55	Steel factor	IL-6	4254	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Steel_factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta .
7679598	0	Steel_factor	33,45	SLF	47,50	Steel factor	SLF	4254	4254	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Decreased endogenous circulating Steel_factor -LRB- SLF -RRB- levels following allogeneic and autologous BMT : lack of an inverse correlation with post-BMT myeloid engraftment .
8704168	0	Steel_factor	0,12	Stat3	47,52	Steel factor	Stat3	4254	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Steel_factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines .
7512047	0	Steel_factor	29,41	c-kit_ligand	43,55	Steel factor	c-kit ligand	4254	4254	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of recombinant human Steel_factor -LRB- c-kit_ligand -RRB- on early cord blood hematopoietic precursors .
19477878	0	Stella	34,40	Oct-4	0,5	Stella	Oct-4	73708(Tax:10090)	100846986	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oct-4 regulates the expression of Stella and Foxj2 at the Nanog locus : implications for the developmental competence of mouse oocytes .
26053644	0	Stem_Cell_Antigen-1	41,60	TGFb	23,27	Stem Cell Antigen-1	TGFb	110454(Tax:10090)	21803(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	Negative Regulation of TGFb Signaling by Stem_Cell_Antigen-1 Protects against Ischemic_Acute_Kidney_Injury .
26505626	0	Stem_Cell_Factor	18,34	CD34	107,111	Stem Cell Factor	CD34	4254	947	Gene	Gene	Sequence|compound|START_ENTITY Residues|nmod|Sequence Capable|nsubj|Residues Capable|acl|Stimulating Stimulating|dobj|Expansion Expansion|nmod|Cells Cells|compound|END_ENTITY	Residues 39-56 of Stem_Cell_Factor Protein Sequence Are Capable of Stimulating the Expansion of Cord Blood CD34 + Cells .
25962936	0	Stem_Cell_Factor	79,95	KIT	26,29	Stem Cell Factor	KIT	4254	3815	Gene	Gene	Secretion|nmod|START_ENTITY Human|dobj|Secretion Human|nsubj|Maintenance Maintenance|nmod|END_ENTITY	Maintenance of Clonogenic KIT -LRB- + -RRB- Human Colon_Tumor Cells Requires Secretion of Stem_Cell_Factor by Differentiated Tumor Cells .
25962936	0	Stem_Cell_Factor	79,95	KIT	26,29	Stem Cell Factor	KIT	4254	3815	Gene	Gene	Secretion|nmod|START_ENTITY Human|dobj|Secretion Human|nsubj|Maintenance Maintenance|nmod|END_ENTITY	Maintenance of Clonogenic KIT -LRB- + -RRB- Human Colon_Tumor Cells Requires Secretion of Stem_Cell_Factor by Differentiated Tumor Cells .
17855052	0	Stem_Cell_Factor	115,131	c-KIT	31,36	Stem Cell Factor	c-KIT	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	differ|nmod|START_ENTITY differ|nsubj|cells cells|acl|expressing expressing|dobj|isoforms isoforms|amod|END_ENTITY	Early myeloid cells expressing c-KIT isoforms differ in signal transduction , survival and chemotactic responses to Stem_Cell_Factor .
11145659	0	Stem_cell_factor	0,16	CD34	103,107	Stem cell factor	CD34	4254	947	Gene	Gene	required|nsubjpass|START_ENTITY required|xcomp|sustain sustain|dobj|expansion expansion|nmod|DR DR|compound|END_ENTITY	Stem_cell_factor and FLT3-ligand are strictly required to sustain the long-term expansion of primitive CD34 + DR - dendritic cell precursors .
25899394	0	Stem_cell_factor	0,16	CD34	110,114	Stem cell factor	CD34	17311(Tax:10090)	12490(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|advcl|preserving preserving|dobj|capacity capacity|nmod|vivo vivo|acl|expanded expanded|dobj|cells cells|compound|END_ENTITY	Stem_cell_factor is essential for preserving NOD/SCID reconstitution capacity of ex vivo expanded cord blood CD34 -LRB- + -RRB- cells .
25899394	0	Stem_cell_factor	0,16	CD34	110,114	Stem cell factor	CD34	17311(Tax:10090)	12490(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|advcl|preserving preserving|dobj|capacity capacity|nmod|vivo vivo|acl|expanded expanded|dobj|cells cells|compound|END_ENTITY	Stem_cell_factor is essential for preserving NOD/SCID reconstitution capacity of ex vivo expanded cord blood CD34 -LRB- + -RRB- cells .
7520394	0	Stem_cell_factor	0,16	CD34	92,96	Stem cell factor	CD34	4254	947	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|proliferation proliferation|nmod|+ +|compound|END_ENTITY	Stem_cell_factor -LRB- c-kit_ligand -RRB- enhances the interleukin-9-dependent proliferation of human CD34 + and CD34 + CD33-DR - cells .
9746786	0	Stem_cell_factor	0,16	CD34	144,148	Stem cell factor	CD34	4254	947	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|proliferation proliferation|nmod|fraction fraction|nmod|cells cells|compound|END_ENTITY	Stem_cell_factor as a single agent induces selective proliferation of the Philadelphia chromosome positive fraction of chronic_myeloid_leukemia CD34 -LRB- + -RRB- cells .
12393527	0	Stem_cell_factor	0,16	FLIP	45,49	Stem cell factor	FLIP	4254	8837	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Stem_cell_factor increases the expression of FLIP that inhibits IFNgamma - induced apoptosis in human erythroid progenitor cells .
18834862	0	Stem_cell_factor	0,16	HIF-1alpha	25,35	Stem cell factor	HIF-1alpha	4254	3091	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Stem_cell_factor induces HIF-1alpha at normoxia in hematopoietic cells .
14597766	0	Stem_cell_factor	0,16	IL-6	54,58	Stem cell factor	IL-6	17311(Tax:10090)	16193(Tax:10090)	Gene	Gene	restores|nsubj|START_ENTITY restores|nmod|mice mice|compound|END_ENTITY	Stem_cell_factor restores hepatocyte proliferation in IL-6 knockout mice following 70 % hepatectomy .
24453276	0	Stem_cell_factor	0,16	IL-6	50,54	Stem cell factor	IL-6	17311(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Stem_cell_factor induces AP-1-dependent mast cell IL-6 production via MAPK kinase 3 activity .
9759910	0	Stem_cell_factor	0,16	SCF	18,21	Stem cell factor	SCF	4254	4254	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Stem_cell_factor -LRB- SCF -RRB- levels in newborns .
12829027	0	Stem_cell_factor	0,16	STAT5	121,126	Stem cell factor	STAT5	4254	6776	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|transactivation transactivation|nmod|signal_transducer_and_activator_of_transcription_5 signal_transducer_and_activator_of_transcription_5|appos|END_ENTITY	Stem_cell_factor enhances erythropoietin-mediated transactivation of signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- via the PKA/CREB pathway .
15671147	0	Stem_cell_factor	0,16	STAT5	65,70	Stem cell factor	STAT5	4254	6776	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Stem_cell_factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase .
11042182	1	Stem_cell_factor	76,92	Stat5	119,124	Stem cell factor	Stat5	17311(Tax:10090)	20850(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Stem_cell_factor induces the expression of Stat5 and erythropoietin_receptor , resulting in efficient proliferation and survival by erythropoietin .
16213778	0	Stem_cell_factor	0,16	c-Kit	17,22	Stem cell factor	c-Kit	4254	3815	Gene	Gene	START_ENTITY|parataxis|regulate regulate|nsubj|interactions interactions|amod|END_ENTITY	Stem_cell_factor / c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation .
18372228	0	Stem_cell_factor	0,16	c-Kit	17,22	Stem cell factor	c-Kit	4254	3815	Gene	Gene	START_ENTITY|parataxis|signalling signalling|nsubj|END_ENTITY	Stem_cell_factor / c-Kit signalling in normal and androgenetic_alopecia hair follicles .
20589425	0	Stem_cell_factor	0,16	c-Kit	17,22	Stem cell factor	c-Kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|supports supports|nsubj|signaling signaling|amod|END_ENTITY	Stem_cell_factor / c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes .
10582791	0	Stem_cell_factor	0,16	c-kit	17,22	Stem cell factor	c-kit	4254	3815	Gene	Gene	START_ENTITY|dep|system system|amod|END_ENTITY	Stem_cell_factor / c-kit system in spermatogenesis .
10849422	0	Stem_cell_factor	0,16	c-kit	17,22	Stem cell factor	c-kit	4254	3815	Gene	Gene	START_ENTITY|parataxis|cyclin_D3 cyclin_D3|nsubj|up-regulates up-regulates|amod|END_ENTITY	Stem_cell_factor / c-kit up-regulates cyclin_D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 _ S6_kinase pathway in spermatogonia .
11438205	0	Stem_cell_factor	0,16	c-kit	26,31	Stem cell factor	c-kit	4254	3815	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|cells cells|amod|END_ENTITY	Stem_cell_factor protects c-kit + human primary erythroid cells from apoptosis .
1381568	0	Stem_cell_factor	1,17	c-kit	18,23	Stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|-RSB- -RSB-|nsubj|interaction interaction|amod|END_ENTITY	-LSB- Stem_cell_factor / c-kit interaction in primordial germ cell , melanoblast and hematopoietic progenitors -RSB- .
14985355	0	Stem_cell_factor	0,16	c-kit	17,22	Stem cell factor	c-kit	4254	3815	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|signaling signaling|amod|END_ENTITY	Stem_cell_factor / c-kit signaling promotes the survival , migration , and capillary tube formation of human umbilical vein endothelial cells .
17410437	0	Stem_cell_factor	0,16	c-kit	17,22	Stem cell factor	c-kit	4254	3815	Gene	Gene	START_ENTITY|parataxis|enhances enhances|nsubj|signaling signaling|amod|END_ENTITY	Stem_cell_factor / c-kit receptor signaling enhances the proliferation and invasion of colorectal_cancer cells through the PI3K/Akt pathway .
8527164	0	Stem_cell_factor	0,16	c-kit	84,89	Stem cell factor	c-kit	4254	3815	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|acl:relcl|associates associates|nmod|END_ENTITY	Stem_cell_factor induces phosphorylation of a 200 kDa protein which associates with c-kit .
7522518	0	Stem_cell_factor	0,16	interleukin-3	97,110	Stem cell factor	interleukin-3	4254	3562	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|extent extent|nmod|END_ENTITY	Stem_cell_factor enhances the growth of primitive erythroid progenitors to a greater extent than interleukin-3 in patients with aplastic_anaemia .
8605334	0	Stem_cell_factor	0,16	interleukin-3	26,39	Stem cell factor	interleukin-3	4254	3562	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|induction induction|amod|dependent dependent|amod|END_ENTITY	Stem_cell_factor enhances interleukin-3 dependent induction of 68-kD calmodulin-binding_protein and thymidine kinase activity in NFS-60 cells .
10880748	0	Stem_cell_factor	0,16	substance_P	76,87	Stem cell factor	substance P	17311(Tax:10090)	21333(Tax:10090)	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Stem_cell_factor and interleukin-4 increase responsiveness of mast cells to substance_P .
22147502	0	Stereocilin	42,53	STRC	55,59	Stereocilin	STRC	161497	161497	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genome-wide SNP genotyping identifies the Stereocilin -LRB- STRC -RRB- gene as a major contributor to pediatric bilateral sensorineural hearing_impairment .
26496121	0	Steroid_Receptor_RNA_Activator	39,69	SRA	71,74	Steroid Receptor RNA Activator	SRA	10011	10011	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of the Long Non-coding RNA Steroid_Receptor_RNA_Activator -LRB- SRA -RRB- with TrxG and PRC2 Complexes .
23907597	0	Steroid_receptor_RNA_activator_protein	0,38	SRAP	40,44	Steroid receptor RNA activator protein	SRAP	10011	10011	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Steroid_receptor_RNA_activator_protein -LRB- SRAP -RRB- expression as a prognostic factor in ER + human breast_tumors .
10551785	0	Steroid_receptor_coactivator-1	0,30	p53	126,129	Steroid receptor coactivator-1	p53	8648	7157	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	Steroid_receptor_coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53 .
18593949	0	Steroid_receptor_coactivator-3	0,30	AIB1	31,35	Steroid receptor coactivator-3	AIB1	8202	8202	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Steroid_receptor_coactivator-3 / AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression .
10418988	0	Steroidogenic_Acute_Regulatory	95,125	StAR	127,131	Steroidogenic Acute Regulatory	StAR	6770	6770	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Effects of disruption of the mitochondrial electrochemical gradient on steroidogenesis and the Steroidogenic_Acute_Regulatory -LRB- StAR -RRB- protein .
17018137	0	Steroidogenic_acute_regulatory	0,30	StAR	40,44	Steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Steroidogenic_acute_regulatory protein -LRB- StAR -RRB- : evidence of gonadotropin-induced steroidogenesis in Alzheimer_disease .
18398688	0	Steroidogenic_acute_regulatory	0,30	StAR	32,36	Steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Steroidogenic_acute_regulatory -LRB- StAR -RRB- protein and cholesterol side-chain cleavage -LRB- P450scc -RRB- - regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish .
15523052	0	Steroidogenic_factor-1	0,22	cAMP_response_element-binding_protein	38,75	Steroidogenic factor-1	cAMP response element-binding protein	2516	1385	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Steroidogenic_factor-1 interacts with cAMP_response_element-binding_protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer .
15721010	0	Sterol-regulatory-element_binding_protein	0,41	hepatic_lipase	90,104	Sterol-regulatory-element binding protein	hepatic lipase	7555	3990	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Sterol-regulatory-element_binding_protein inhibits upstream stimulatory factor-stimulated hepatic_lipase gene expression .
10455139	0	Sterol_regulatory_element-binding_protein	0,41	microsomal_triglyceride_transfer_protein	63,103	Sterol regulatory element-binding protein	microsomal triglyceride transfer protein	7555	4547	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	Sterol_regulatory_element-binding_protein negatively regulates microsomal_triglyceride_transfer_protein gene transcription .
21084441	0	Sterol_regulatory_element-binding_protein_2	0,43	SREBP2	45,51	Sterol regulatory element-binding protein 2	SREBP2	20788(Tax:10090)	20788(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Sterol_regulatory_element-binding_protein_2 -LRB- SREBP2 -RRB- activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes .
21871872	0	Sterol_regulatory_element_binding_protein-1	0,43	SREBP1	45,51	Sterol regulatory element binding protein-1	SREBP1	6720	6720	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Sterol_regulatory_element_binding_protein-1 -LRB- SREBP1 -RRB- activation in motor neurons in excitotoxicity and amyotrophic_lateral_sclerosis -LRB- ALS -RRB- : Indip , a potential therapeutic peptide .
23403193	0	Sterol_regulatory_element_binding_transcription_factor_1	0,56	SREBF1	58,64	Sterol regulatory element binding transcription factor 1	SREBF1	6720	6720	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Sterol_regulatory_element_binding_transcription_factor_1 -LRB- SREBF1 -RRB- polymorphism and milk fatty_acid composition .
12525481	0	Sti1	0,4	Hsp90	43,48	Sti1	Hsp90	854192(Tax:4932)	855836(Tax:4932)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|ATPase ATPase|compound|END_ENTITY	Sti1 is a non-competitive inhibitor of the Hsp90 ATPase .
14742721	0	Sti1	0,4	Hsp90	29,34	Sti1	Hsp90	854192(Tax:4932)	855836(Tax:4932)	Gene	Gene	stabilize|nsubj|START_ENTITY stabilize|dobj|END_ENTITY	Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase .
16219779	0	Sti1	87,91	Hsp90	95,100	Sti1	Hsp90	854192(Tax:4932)	855836(Tax:4932)	Gene	Gene	domains|nmod|START_ENTITY repeat|dobj|domains repeat|nmod|signaling signaling|amod|END_ENTITY	Effect of mutation of the tetratricopeptide repeat and asparatate-proline 2 domains of Sti1 on Hsp90 signaling and interaction in Saccharomyces_cerevisiae .
17101799	0	Sti1	97,101	Hsp90	61,66	Sti1	Hsp90	854192(Tax:4932)	855836(Tax:4932)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Nucleotide-dependent interaction of Saccharomyces_cerevisiae Hsp90 with the cochaperone proteins Sti1 , Cpr6 , and Sba1 .
25851214	0	Sti1	48,52	Hsp90	0,5	Sti1	Hsp90	10963	3320	Gene	Gene	dynamics|nmod|START_ENTITY regulates|dobj|dynamics regulates|nsubj|END_ENTITY	Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules .
8972212	0	Sti1	42,46	Hsp90	24,29	Sti1	Hsp90	854192(Tax:4932)	855836(Tax:4932)	Gene	Gene	cochaperone|nsubj|START_ENTITY cochaperone|nmod|analysis analysis|nmod|END_ENTITY	In vivo analysis of the Hsp90 cochaperone Sti1 -LRB- p60 -RRB- .
21378336	0	Stk11	41,46	Lkb1	48,52	Stk11	Lkb1	314621(Tax:10116)	314621(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations and aberrant transcriptions of Stk11 -LRB- Lkb1 -RRB- gene in rat liver_tumors .
20080709	0	Stk40	0,5	Oct4	36,40	Stk40	Oct4	74178(Tax:10090)	100846986	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation .
9042864	0	Stn1	0,4	Cdc13	108,113	Stn1	Cdc13	851655(Tax:4932)	851306(Tax:4932)	Gene	Gene	implicated|nsubjpass|START_ENTITY implicated|nmod|END_ENTITY	Stn1 , a new Saccharomyces_cerevisiae protein , is implicated in telomere size regulation in association with Cdc13 .
19648609	0	Stn1	63,67	OB_fold-containing_protein_1	0,28	TRF2	OB fold-containing protein 1	7014	79991	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	OB_fold-containing_protein_1 -LRB- OBFC1 -RRB- , a human homolog of yeast Stn1 , associates with TPP1 and is implicated in telomere length regulation .
11230140	0	Stn1	84,88	Ten1	0,4	Stn1	Ten1	851655(Tax:4932)	850696(Tax:4932)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13 .
20472560	0	Stomatal_Cytokinesis-Defective_1	19,51	SCD1	53,57	Stomatal Cytokinesis-Defective 1	SCD1	841327(Tax:3702)	841327(Tax:3702)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Novel functions of Stomatal_Cytokinesis-Defective_1 -LRB- SCD1 -RRB- in innate immune responses against bacteria .
19696025	0	Stomatin-like_protein-1	0,23	stomatin	39,47	Stomatin-like protein-1	stomatin	9399	2040	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Stomatin-like_protein-1 interacts with stomatin and is targeted to late endosomes .
26437238	0	Stonin1	0,7	NG2	49,52	Stonin1	NG2	77057(Tax:10090)	121021(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|endocytosis endocytosis|nmod|END_ENTITY	Stonin1 mediates endocytosis of the proteoglycan NG2 and regulates focal adhesion dynamics and cell motility .
8601031	0	Stra7	39,44	Gbx-2	46,51	Stra7	Gbx-2	14472(Tax:10090)	14472(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence and expression pattern of the Stra7 -LRB- Gbx-2 -RRB- homeobox-containing gene induced by retinoic_acid in P19 embryonal_carcinoma cells .
21621532	0	Stra8	58,63	DMRT1	0,5	Stra8	DMRT1	346673	1761	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary .
26223799	0	Striatal-Enriched_Protein_Tyrosine_Phosphatase	13,59	BDNF	0,4	Striatal-Enriched Protein Tyrosine Phosphatase	BDNF	84867	627	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	BDNF Induces Striatal-Enriched_Protein_Tyrosine_Phosphatase 61 Degradation Through the Proteasome .
21863137	0	Striatal-Enriched_Protein_Tyrosine_Phosphatase	12,58	STEP	60,64	Striatal-Enriched Protein Tyrosine Phosphatase	STEP	84867	84867	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	The Role of Striatal-Enriched_Protein_Tyrosine_Phosphatase -LRB- STEP -RRB- in Cognition .
22462026	0	Stromal-Cell-Derived_Factor-1	0,29	CXCL12	38,44	Stromal-Cell-Derived Factor-1	CXCL12	6387	6387	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Stromal-Cell-Derived_Factor-1 -LRB- SDF-1 -RRB- / CXCL12 as Potential Target of Therapeutic Angiogenesis in Critical Leg_Ischaemia .
21186999	0	Stromal-derived_factor-1	0,24	CXCR4	25,30	Stromal-derived factor-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|dep|signaling signaling|compound|END_ENTITY	Stromal-derived_factor-1 / CXCR4 signaling : indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow .
25562157	0	Stromal_Cell-Derived_Factor-1	61,90	CXCR4	100,105	Stromal Cell-Derived Factor-1	CXCR4	6387	7852	Gene	Gene	Viability|compound|START_ENTITY Viability|compound|END_ENTITY	Human Breast Adipose-Derived Stem Cells Transfected with the Stromal_Cell-Derived_Factor-1 Receptor CXCR4 Exhibit Enhanced Viability in Human Autologous Free Fat Grafts .
26546674	0	Stromal_Interaction_Molecule_1	23,53	Calcium_Release-Activated_Calcium_Modulator_1	88,133	Stromal Interaction Molecule 1	Calcium Release-Activated Calcium Modulator 1	6786	84876	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
26546674	0	Stromal_Interaction_Molecule_1	23,53	Orai1	135,140	Stromal Interaction Molecule 1	Orai1	6786	84876	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|Calcium_Release-Activated_Calcium_Modulator_1 Calcium_Release-Activated_Calcium_Modulator_1|appos|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
26546674	0	Stromal_Interaction_Molecule_1	23,53	STIM1	55,60	Stromal Interaction Molecule 1	STIM1	6786	6786	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Cooperative Binding of Stromal_Interaction_Molecule_1 -LRB- STIM1 -RRB- to the N and C Termini of Calcium_Release-Activated_Calcium_Modulator_1 -LRB- Orai1 -RRB- .
15542441	0	Stromal_cell-derived_factor-1	0,29	CXCR4	38,43	Stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	\|nsubj|START_ENTITY \|ccomp|plays plays|nsubj|couple couple|compound|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- \ CXCR4 couple plays multiple roles on haematopoietic progenitors at the border between the old cytokine and new chemokine worlds : survival , cell cycling and trafficking .
17038674	0	Stromal_cell-derived_factor-1	0,29	CXCR4	30,35	Stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|parataxis|modifies modifies|nsubj|signaling signaling|compound|END_ENTITY	Stromal_cell-derived_factor-1 / CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro .
19327121	0	Stromal_cell-derived_factor-1	0,29	CXCR4	52,57	Stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|dobj|susceptibility susceptibility|dep|END_ENTITY	Stromal_cell-derived_factor-1 but not its receptor , CXCR4 , gene variants increase susceptibility and pathological development of hepatocellular_carcinoma .
21567300	0	Stromal_cell-derived_factor-1	0,29	CXCR4	74,79	Stromal cell-derived factor-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	_|amod|START_ENTITY _|nsubj|_ _|ccomp|induces induces|nsubj|activation activation|appos|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / chemokine _ -LRB- C-X-C_motif -RRB- _ receptor_4 -LRB- CXCR4 -RRB- axis activation induces intra-islet glucagon-like_peptide-1 -LRB- GLP-1 -RRB- production and enhances beta cell survival .
24762228	0	Stromal_cell-derived_factor-1	0,29	CXCR4	38,43	Stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	START_ENTITY|dep|axis axis|nummod|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- / CXCR4 axis enhances cellular invasion in ovarian_carcinoma cells via integrin b1 and b3 expressions .
21567400	0	Stromal_cell-derived_factor-1	0,29	CXC_receptor_4	30,44	Stromal cell-derived factor-1	CXC receptor 4	6387	7852	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Stromal_cell-derived_factor-1 / CXC_receptor_4 and b1 integrin interaction regulates urokinase-type_plasminogen_activator expression in human colorectal_cancer cells .
10648384	0	Stromal_cell-derived_factor-1	0,29	thrombopoietin	57,71	Stromal cell-derived factor-1	thrombopoietin	20315(Tax:10090)	21832(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells -LRB- CFU-MK -RRB- .
22916036	0	Stromal_liver_kinase_B1	0,23	STK11	25,30	Stromal liver kinase B1	STK11	6794	6794	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Stromal_liver_kinase_B1 -LSB- STK11 -RSB- signaling loss induces oviductal_adenomas and endometrial_cancer by activating mammalian Target of Rapamycin Complex 1 .
12697065	0	Stromelysin-1_and_mesothelin	0,28	Wnt-5a	61,67	Stromelysin-1 and mesothelin	Wnt-5a	10232	7474	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Stromelysin-1_and_mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells .
20833645	0	Strumpellin	0,11	valosin-containing_protein	23,49	Strumpellin	valosin-containing protein	9897	7415	Gene	Gene	partner|nsubj|START_ENTITY partner|amod|END_ENTITY	Strumpellin is a novel valosin-containing_protein binding partner linking hereditary_spastic_paraplegia to protein_aggregation_diseases .
20155394	0	Sts	77,80	steroid_sulfatase	58,75	Sts	steroid sulfatase	20905(Tax:10090)	20905(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Brain pathways mediating the pro-aggressive effect of the steroid_sulfatase -LRB- Sts -RRB- gene .
9606209	0	Stu2p	60,65	Spc72p	38,44	Stu2p	Spc72p	850734(Tax:4932)	851250(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The yeast spindle pole body component Spc72p interacts with Stu2p and is required for proper microtubule assembly .
15897714	0	Stxbp1	37,43	syntaxin_binding_protein_1	4,30	Stxbp1	syntaxin binding protein 1	20910(Tax:10090)	20910(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The syntaxin_binding_protein_1 gene -LRB- Stxbp1 -RRB- is a candidate for an ethanol preference drinking locus on mouse chromosome 2 .
14668376	0	SuUR	46,50	Suppressor_of_Underreplication	14,44	SuUR	Suppressor of Underreplication	45739(Tax:7227)	45739(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effect of the Suppressor_of_Underreplication -LRB- SuUR -RRB- gene on position-effect variegation silencing in Drosophila_melanogaster .
22973055	0	Sub1	0,4	Spt5	21,25	Sub1	Spt5	855055(Tax:4932)	854999(Tax:4932)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Sub1 associates with Spt5 and influences RNA polymerase II transcription elongation rate .
26851015	0	Submaxillary_Gland_Androgen-regulated_Protein_3A	14,62	SMR3A	64,69	Submaxillary Gland Androgen-regulated Protein 3A	SMR3A	26952	26952	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Submaxillary_Gland_Androgen-regulated_Protein_3A -LRB- SMR3A -RRB- in Adenoid_Cystic_Carcinoma of the Head_and_Neck .
22244942	0	Substance_P	0,11	ADAM9	22,27	Substance P	ADAM9	6863	8754	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nummod|END_ENTITY	Substance_P activates ADAM9 mRNA expression and induces a-secretase-mediated amyloid precursor protein cleavage .
17924972	0	Substance_P	0,11	C-C_ligand_20	71,84	Substance P	C-C ligand 20	6863	6364	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Substance_P regulates macrophage_inflammatory_protein_3alpha / chemokine C-C_ligand_20 -LRB- CCL20 -RRB- with heme_oxygenase-1 in human periodontal ligament cells .
21945803	0	Substance_P	0,11	CCN1	20,24	Substance P	CCN1	6863	3491	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Substance_P induces CCN1 expression via histone_deacetylase activity in human colonic epithelial cells .
25268585	0	Substance_P	0,11	Endothelin-Converting_Enzyme_1	50,80	Substance P	Endothelin-Converting Enzyme 1	6863	1889	Gene	Gene	Secretion|compound|START_ENTITY Secretion|nmod|END_ENTITY	Substance_P Stimulates Endothelin_1 Secretion via Endothelin-Converting_Enzyme_1 and Promotes Melanogenesis in Human Melanocytes .
25268585	0	Substance_P	0,11	Endothelin_1	23,35	Substance P	Endothelin 1	6863	1906	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	Substance_P Stimulates Endothelin_1 Secretion via Endothelin-Converting_Enzyme_1 and Promotes Melanogenesis in Human Melanocytes .
7686934	0	Substance_P	0,11	IFN-gamma	39,48	Substance P	IFN-gamma	21333(Tax:10090)	15978(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|amod|END_ENTITY	Substance_P modulates antigen-induced , IFN-gamma production in murine Schistosomiasis mansoni .
1375246	0	Substance_P	0,11	IL-2	21,25	Substance P	IL-2	6863	3558	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Substance_P enhances IL-2 expression in activated human T cells .
11053288	0	Substance_P	0,11	IL-8	38,42	Substance P	IL-8	6863	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Substance_P differentially stimulates IL-8 synthesis in human corneal epithelial cells .
11966980	0	Substance_P	11,22	NK-1_receptor	95,108	Substance P	NK-1 receptor	6863	6869	Gene	Gene	Analogs|nmod|START_ENTITY modified|nsubj|Analogs modified|nmod|C-terminus C-terminus|acl:relcl|agonist agonist|nmod|END_ENTITY	Analogs of Substance_P modified at the C-terminus which are both agonist and antagonist of the NK-1_receptor depending on the second messenger pathway .
19076365	0	Substance_P	0,11	NK-1_receptor	35,48	Substance P	NK-1 receptor	6863	6869	Gene	Gene	START_ENTITY|dep|interacts interacts|compound|END_ENTITY	Substance_P in stress and anxiety : NK-1_receptor antagonism interacts with key brain areas of the stress circuitry .
23996004	0	Substance_P	0,11	NK-1_receptor	71,84	Substance P	NK-1 receptor	6863	6869	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|stimulation stimulation|compound|END_ENTITY	Substance_P reduces TNF-a-induced apoptosis in human tenocytes through NK-1_receptor stimulation .
16612568	0	Substance_P	0,11	RANKL	34,39	Substance P	RANKL	6863	8600	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Substance_P stimulates release of RANKL via COX-2 expression in human dental pulp cells .
7683320	0	Substance_P	0,11	TNF-alpha	34,43	Substance P	TNF-alpha	21333(Tax:10090)	21926(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Substance_P selectively activates TNF-alpha gene expression in murine mast cells .
15522699	0	Substance_P	0,11	TRPV1	26,31	Substance P	TRPV1	21333(Tax:10090)	193034(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Substance_P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung .
20303589	0	Substance_P	80,91	TRPV1	53,58	Substance P	TRPV1	21333(Tax:10090)	193034(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of genetic deletion of the vanilloid receptor TRPV1 on the expression of Substance_P in sensory neurons of mice with adjuvant-induced_arthritis .
24516103	0	Substance_P	0,11	angiotensin-converting_enzyme	59,88	Substance P	angiotensin-converting enzyme	6863	1636	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Substance_P increases sympathetic activity during combined angiotensin-converting_enzyme and dipeptidyl_peptidase-4 inhibition .
2457810	0	Substance_P	0,11	calcitonin_gene-related_peptide	50,81	Substance P	calcitonin gene-related peptide	6863	796	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Substance_P regulates the vasodilator activity of calcitonin_gene-related_peptide .
16585602	0	Substance_P	0,11	cyclooxygenase-2	23,39	Substance P	cyclooxygenase-2	6863	5743	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Substance_P stimulates cyclooxygenase-2 and prostaglandin_E2 expression through JAK-STAT activation in human colonic epithelial cells .
20926798	0	Substance_P	0,11	cyclooxygenase-2	24,40	Substance P	cyclooxygenase-2	21333(Tax:10090)	19225(Tax:10090)	Gene	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	Substance_P upregulates cyclooxygenase-2 and prostaglandin_E metabolite by activating ERK1/2 and NF-kappaB in a mouse model of burn-induced remote acute_lung_injury .
7479308	0	Substance_P	0,11	intercellular_adhesion_molecule-1	38,71	Substance P	intercellular adhesion molecule-1	6863	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Substance_P induces the expression of intercellular_adhesion_molecule-1 on vascular endothelial cells and enhances neutrophil transendothelial migration .
2449707	0	Substance_P	0,11	interferon-gamma	21,37	Substance P	interferon-gamma	6863	3458	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|amod|END_ENTITY	Substance_P enhances interferon-gamma production by human peripheral blood mononuclear cells .
12485430	0	Substance_P	0,11	interferon-induced_protein_of_10_kDa	39,75	Substance P	interferon-induced protein of 10 kDa	6863	3627	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Substance_P enhances the production of interferon-induced_protein_of_10_kDa by human keratinocytes in synergy with interferon-gamma .
7512581	0	Substance_P	0,11	interleukin-2	23,36	Substance P	interleukin-2	6863	3558	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|compound|END_ENTITY	Substance_P stabilizes interleukin-2 mRNA in activated Jurkat cells .
9523575	0	Substance_P	0,11	interleukin-6	33,46	Substance P	interleukin-6	6863	3569	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Substance_P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6 .
14561975	0	Substance_P	0,11	interleukin-8	20,33	Substance P	interleukin-8	6863	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Substance_P induces interleukin-8 secretion from human dental pulp cells .
12799848	0	Substance_P	1,12	somatostatin	14,26	Substance P	somatostatin	6863	6750	Gene	Gene	START_ENTITY|appos|transmitters transmitters|compound|END_ENTITY	-LSB- Substance_P , somatostatin and monoaminergic transmitters in the cerebrospinal fluid of patients with chronic idiopathic_trigeminal_neuralgia -RSB- .
9834121	0	Substance_P	0,11	somatostatin	22,34	Substance P	somatostatin	21333(Tax:10090)	20604(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Substance_P regulates somatostatin expression in inflammation .
8780727	0	Suc1-associated_neurotrophic_factor_target	0,42	SNT	44,47	Suc1-associated neurotrophic factor target	SNT	10818	10818	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Suc1-associated_neurotrophic_factor_target -LRB- SNT -RRB- protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 .
16733284	0	Sudden_Infant_Death_Syndrome	18,46	SIDS	48,52	Sudden Infant Death Syndrome	SIDS	3423	3423	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	-LSB- The influence of Sudden_Infant_Death_Syndrome -LRB- SIDS -RRB- risk factors on health , growth and development in the first year of life .
19622347	0	Sufu	0,4	GSK3beta	14,22	Sufu	GSK3beta	51684	2932	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Sufu recruits GSK3beta for efficient processing of Gli3 .
19684112	0	Sufu	57,61	Gli	33,36	Sufu	Gli	41565(Tax:7227)	34927(Tax:7227)	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved .
19684112	0	Sufu	57,61	Hedgehog	65,73	Sufu	Hedgehog	41565(Tax:7227)	42737(Tax:7227)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved .
25403183	0	Sufu	14,18	p66b	31,35	Sufu	p66b	51684	57459	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Regulation of Sufu activity by p66b and Mycbp provides new insight into vertebrate Hedgehog signaling .
16499872	0	Sug1	46,50	MYO18B	0,6	Sug1	MYO18B	5705	84700	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway .
18318435	0	Sulfatase_2	0,11	glypican_3	25,35	Sulfatase 2	glypican 3	55959	2719	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Sulfatase_2 up-regulates glypican_3 , promotes fibroblast growth factor signaling , and decreases survival_in_hepatocellular_carcinoma .
8848570	0	Sulfated_glycoprotein-1	0,23	SGP-1	25,30	Sulfated glycoprotein-1	SGP-1	25524(Tax:10116)	25524(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sulfated_glycoprotein-1 -LRB- SGP-1 -RRB- expression in ovine endometrium during the oestrous cycle and early pregnancy .
1749509	0	Sulfated_glycoprotein-2	0,23	SGP-2	25,30	Sulfated glycoprotein-2	SGP-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Sulfated_glycoprotein-2 -LRB- SGP-2 -RRB- mRNA is expressed in rat striatal astrocytes following ibotenic_acid lesions .
19057013	0	Sulfiredoxin	0,12	AP-1	19,23	Sulfiredoxin	AP-1	140809	3725	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin_malignancies .
22934964	0	Sulfiredoxin	0,12	S100A4	46,52	Sulfiredoxin	S100A4	140809	6275	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility .
14643027	0	Sulfotransferase_1A1	0,20	SULT1A1	22,29	Sulfotransferase 1A1	SULT1A1	6817	6817	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Sulfotransferase_1A1 -LRB- SULT1A1 -RRB- polymorphism and bladder_cancer risk : a case-control study .
15093672	0	Sulfotransferase_1A1	0,20	SULT1A1	22,29	Sulfotransferase 1A1	SULT1A1	6817	6817	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Sulfotransferase_1A1 -LRB- SULT1A1 -RRB- polymorphism and breast_cancer risk in Chinese women .
14507919	0	Sup35	50,55	Hsp104	79,85	Sup35	Hsp104	851752(Tax:4932)	850633(Tax:4932)	Gene	Gene	polymers|amod|START_ENTITY polymers|acl|fragmented fragmented|nmod|END_ENTITY	Yeast -LSB- PSI + -RSB- prion aggregates are formed by small Sup35 polymers fragmented by Hsp104 .
15155912	0	Sup35	63,68	Hsp104	0,6	Sup35	Hsp104	851752(Tax:4932)	850633(Tax:4932)	Gene	Gene	conformers|amod|START_ENTITY formation|nmod|conformers catalyzes|dobj|formation catalyzes|nsubj|END_ENTITY	Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers .
15448141	0	Sup35	22,27	Hsp104	0,6	Sup35	Hsp104	851752(Tax:4932)	850633(Tax:4932)	Gene	Gene	fiber|nummod|START_ENTITY binds|nmod|fiber binds|nsubj|END_ENTITY	Hsp104 binds to yeast Sup35 prion fiber but needs other factor -LRB- s -RRB- to sever it .
18833196	0	Sup35	81,86	Hsp104	0,6	Sup35	Hsp104	851752(Tax:4932)	850633(Tax:4932)	Gene	Gene	prions|amod|START_ENTITY formation|nmod|prions regulates|dobj|formation regulates|nsubj|END_ENTITY	Hsp104 , Hsp70 and Hsp40 interplay regulates formation , growth and elimination of Sup35 prions .
24216111	0	Sup35	43,48	Hsp104	19,25	Sup35	Hsp104	851752(Tax:4932)	850633(Tax:4932)	Gene	Gene	as|nmod:npmod|START_ENTITY analyzed|advmod|as analyzed|nsubj|interaction interaction|nmod|END_ENTITY	The interaction of Hsp104 with yeast prion Sup35 as analyzed by fluorescence cross-correlation spectroscopy .
9391130	0	Sup35	48,53	Hsp104	30,36	Sup35	Hsp104	851752(Tax:4932)	850633(Tax:4932)	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP .
9195043	0	Sup45p	39,45	eRF1	33,37	Sup45p	eRF1	852440(Tax:4932)	399462(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the release factor eRF1 -LRB- Sup45p -RRB- gene of higher eukaryotes in yeast and mammalian tissues .
20955806	0	Superficial_Zone_Protein	45,69	TGF-b1	11,17	Superficial Zone Protein	TGF-b1	10216	7040	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of TGF-b1 on alternative splicing of Superficial_Zone_Protein in articular cartilage cultures .
15581604	0	Supernatant_protein_factor	0,26	HMG-CoA_reductase	38,55	Supernatant protein factor	HMG-CoA reductase	116486(Tax:10116)	25675(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Supernatant_protein_factor stimulates HMG-CoA_reductase in cell culture and in vitro .
25553268	0	Superoxide_Dismutase	0,20	SOD1	27,31	Superoxide Dismutase	SOD1	6649	6647	Gene	Gene	Gene|compound|START_ENTITY Gene|dep|END_ENTITY	Superoxide_Dismutase Gene -LRB- SOD1 , SOD2 , and SOD3 -RRB- Polymorphisms and Antituberculosis Drug-induced_Hepatitis .
26791230	0	Superoxide_Dismutase_1	88,110	IL-10	0,5	Superoxide Dismutase 1	IL-10	20655(Tax:10090)	16153(Tax:10090)	Gene	Gene	Controls|nmod|START_ENTITY Controls|nsubj|END_ENTITY	IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide_Dismutase_1 .
15576639	0	Superoxide_dismutase	0,20	vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1	48,124	Superoxide dismutase	vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1	6647	7412	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Superoxide_dismutase inhibits the expression of vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1 induced by tumor_necrosis_factor-alpha in human endothelial cells through the JNK/p38 pathways .
18604212	0	Superoxide_dismutase_1	0,22	caspase-1	33,42	Superoxide dismutase 1	caspase-1	20655(Tax:10090)	12362(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Superoxide_dismutase_1 regulates caspase-1 and endotoxic_shock .
16680451	0	Superoxide_dismutase_1	0,22	transferrin_receptor	47,67	Superoxide dismutase 1	transferrin receptor	6647	7037	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Superoxide_dismutase_1 modulates expression of transferrin_receptor .
25655724	0	Supervillin	0,11	Trio	34,38	Supervillin	Trio	6840	7204	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation .
11792840	0	Supervillin	0,11	androgen_receptor	28,45	Supervillin	androgen receptor	6840	367	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Supervillin associates with androgen_receptor and modulates its transcriptional activity .
18981224	0	Suppressor_2_of_zeste	23,44	Posterior_Sex_Combs	72,91	Suppressor 2 of zeste	Posterior Sex Combs	36432(Tax:7227)	36431(Tax:7227)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Polycomb group protein Suppressor_2_of_zeste is a functional homolog of Posterior_Sex_Combs .
25849377	0	Suppressor_of_Cytokine_Signaling	0,32	SOCS	34,38	Suppressor of Cytokine Signaling	SOCS	1154	1154	Gene	Gene	Genes|amod|START_ENTITY Genes|appos|END_ENTITY	Suppressor_of_Cytokine_Signaling -LRB- SOCS -RRB- Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical_Cancer Cells .
26668321	0	Suppressor_of_Cytokine_Signaling-3	0,34	Proprotein_Convertase_Subtilisin_Kexin_Type_9	52,97	Suppressor of Cytokine Signaling-3	Proprotein Convertase Subtilisin Kexin Type 9	9021	255738	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Suppressor_of_Cytokine_Signaling-3 -LRB- SOCS-3 -RRB- induces Proprotein_Convertase_Subtilisin_Kexin_Type_9 -LRB- PCSK9 -RRB- expression in hepatic HepG2 cell line .
23296734	0	Suppressor_of_Cytokine_Signalling	12,45	SOCS	47,51	Suppressor of Cytokine Signalling	SOCS	12700(Tax:10090)	12700(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of Suppressor_of_Cytokine_Signalling -LRB- SOCS -RRB- gene expression by real-time quantitative PCR .
14668376	0	Suppressor_of_Underreplication	14,44	SuUR	46,50	Suppressor of Underreplication	SuUR	45739(Tax:7227)	45739(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effect of the Suppressor_of_Underreplication -LRB- SuUR -RRB- gene on position-effect variegation silencing in Drosophila_melanogaster .
16543409	0	Suppressor_of_cytokine_Signaling-3	0,34	interleukin-1	44,57	Suppressor of cytokine Signaling-3	interleukin-1	9021	3552	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	Suppressor_of_cytokine_Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6 / TAK1 complex .
15491991	0	Suppressor_of_cytokine_signaling	0,32	SOCS	34,38	Suppressor of cytokine signaling	SOCS	1154	1154	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Suppressor_of_cytokine_signaling -LRB- SOCS -RRB- proteins indirectly regulate toll-like receptor signaling in innate immune cells .
16287972	0	Suppressor_of_cytokine_signaling-1	0,34	IL-6	68,72	Suppressor of cytokine signaling-1	IL-6	8651	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Suppressor_of_cytokine_signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT .
12032139	0	Suppressor_of_cytokine_signaling-1	0,34	tumor_necrosis_factor	89,110	Suppressor of cytokine signaling-1	tumor necrosis factor	8651	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Suppressor_of_cytokine_signaling-1 regulates the sensitivity of pancreatic beta cells to tumor_necrosis_factor .
12928391	0	Suppressor_of_cytokine_signaling_1	0,34	IL-15	45,50	Suppressor of cytokine signaling 1	IL-15	12703(Tax:10090)	16168(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|receptor receptor|compound|END_ENTITY	Suppressor_of_cytokine_signaling_1 regulates IL-15 receptor signaling in CD8 + CD44high memory T lymphocytes .
21234523	0	Suppressor_of_cytokine_signaling_1	0,34	lymphocyte-specific_protein_tyrosine_kinase	60,103	Suppressor of cytokine signaling 1	lymphocyte-specific protein tyrosine kinase	8651	3932	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Suppressor_of_cytokine_signaling_1 interacts with oncogenic lymphocyte-specific_protein_tyrosine_kinase .
11297560	0	Suppressor_of_cytokine_signaling_1	0,34	macrophage_colony-stimulating_factor_receptor	54,99	Suppressor of cytokine signaling 1	macrophage colony-stimulating factor receptor	12703(Tax:10090)	12978(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Suppressor_of_cytokine_signaling_1 interacts with the macrophage_colony-stimulating_factor_receptor and negatively regulates its proliferation signal .
20876575	0	Suppressor_of_cytokine_signaling_3	0,34	IL-6	56,60	Suppressor of cytokine signaling 3	IL-6	9021	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Suppressor_of_cytokine_signaling_3 inhibits LPS-induced IL-6 expression in osteoblasts by suppressing CCAAT/enhancer-binding protein -LCB- beta -RCB- activity .
17668875	0	Suppressor_of_cytokine_signaling_3	0,34	SOCS3	36,41	Suppressor of cytokine signaling 3	SOCS3	9021	9021	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- expression and hepatitis_C virus-related chronic hepatitis : Insulin resistance and response to antiviral therapy .
12960061	0	Suppressor_of_cytokine_signaling_3	0,34	angiotensin_II	49,63	Suppressor of cytokine signaling 3	angiotensin II	89829(Tax:10116)	24179(Tax:10116)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Suppressor_of_cytokine_signaling_3 is induced by angiotensin_II in heart and isolated cardiomyocytes , and participates in desensitization .
17683382	0	Suppressor_of_cytokine_signaling_3	0,34	signal_transducer_and_activator_of_transcription_3	58,108	Suppressor of cytokine signaling 3	signal transducer and activator of transcription 3	9021	6774	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Suppressor_of_cytokine_signaling_3 negative regulation of signal_transducer_and_activator_of_transcription_3 in platelet-derived growth factor-induced fibroblast migration .
15677474	0	Suppressor_of_cytokine_signaling_7	0,34	prolactin	44,53	Suppressor of cytokine signaling 7	prolactin	30837	5617	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Suppressor_of_cytokine_signaling_7 inhibits prolactin , growth_hormone , and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation .
21360047	0	Suppressor_of_cytokine_signalling	0,33	SOCS3	42,47	Suppressor of cytokine signalling	SOCS3	1154	9021	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Suppressor_of_cytokine_signalling protein SOCS3 expression is increased at sites of acute_and_chronic_inflammation .
26384335	0	Suppressors_of_Cytokine_Signaling-3	20,55	SOCS3	57,62	Suppressors of Cytokine Signaling-3	SOCS3	9021	9021	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Effects of Reducing Suppressors_of_Cytokine_Signaling-3 -LRB- SOCS3 -RRB- Expression on Dendritic_Outgrowth_and_Demyelination after Spinal_Cord_Injury .
15125881	0	Suppressors_of_cytokine_signalling	0,34	growth_hormone	53,67	Suppressors of cytokine signalling	growth hormone	12700(Tax:10090)	14599(Tax:10090)	Gene	Gene	START_ENTITY|nmod|action action|amod|END_ENTITY	Suppressors_of_cytokine_signalling and regulation of growth_hormone action .
12594205	0	Suprachiasmatic_nucleus_circadian_oscillatory_protein	0,53	K-Ras	82,87	Suprachiasmatic nucleus circadian oscillatory protein	K-Ras	59265(Tax:10116)	24525(Tax:10116)	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Suprachiasmatic_nucleus_circadian_oscillatory_protein , a novel binding partner of K-Ras in the membrane rafts , negatively regulates MAPK pathway .
7739520	0	Surf-3	85,91	rpL7a	78,83	Surf-3	rpL7a	6130	31588(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The genomic organization of the region containing the Drosophila_melanogaster rpL7a -LRB- Surf-3 -RRB- gene differs from those of the mammalian and avian Surfeit loci .
8586415	0	Surf3	123,128	rpL7A	116,121	Surf3	rpL7A	27176(Tax:10090)	27176(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Surf5 : a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A -LRB- Surf3 -RRB- gene .
9277450	0	Surfactant_protein_A	0,20	NF-kappa_B	31,41	Surfactant protein A	NF-kappa B	653509	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Surfactant_protein_A activates NF-kappa_B in the THP-1 monocytic cell line .
23685990	0	Surfactant_protein_A	0,20	TGF-b1	27,33	Surfactant protein A	TGF-b1	653509	7040	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Surfactant_protein_A binds TGF-b1 with high affinity and stimulates the TGF-b pathway .
16754682	0	Surfactant_protein_A	0,20	TLR4	45,49	Surfactant protein A	TLR4	653509	7099	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Surfactant_protein_A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response .
15244040	0	Surfactant_protein_A_and_D	0,26	SP-A	28,32	Surfactant protein A and D	SP-A	653509;6441	653509	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Surfactant_protein_A_and_D -LRB- SP-A , AP-D -RRB- levels in patients with septic ARDS .
11390505	0	Surfactant_protein_D	0,20	NF-kappa_B	31,41	Surfactant protein D	NF-kappa B	20390(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Surfactant_protein_D regulates NF-kappa_B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways .
25472740	0	Surfactant_protein_D	0,20	TGF-b	92,97	Surfactant protein D	TGF-b	20390(Tax:10090)	21803(Tax:10090)	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Surfactant_protein_D attenuates sub-epithelial fibrosis in allergic_airways_disease through TGF-b .
1930130	0	Surfactant_protein_D	0,20	surfactant_protein_A	65,85	Surfactant protein D	surfactant protein A	25350(Tax:10116)	24773(Tax:10116)	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|effect effect|nmod|END_ENTITY	Surfactant_protein_D -LRB- SP-D -RRB- counteracts the inhibitory effect of surfactant_protein_A -LRB- SP-A -RRB- on phospholipid secretion by alveolar type II cells .
12075005	0	Survival_motor_neuron	0,21	SMN	23,26	Survival motor neuron	SMN	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Survival_motor_neuron -LRB- SMN -RRB- protein : role in neurite outgrowth and neuromuscular maturation during neuronal differentiation and development .
9758161	0	Survival_motor_neuron	0,21	SMN	23,26	Survival motor neuron	SMN	64301(Tax:10116)	64301(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Survival_motor_neuron -LRB- SMN -RRB- protein in rat is expressed as different molecular forms and is developmentally regulated .
17881769	0	Survivin	51,59	cyclin_D3	15,24	Survivin	cyclin D3	11799(Tax:10090)	12445(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of cyclin_D3 , CDKN1A -LRB- p21 -RRB- , and BIRC5 -LRB- Survivin -RRB- in interleukin_11 stimulation of decidualization in mice .
17916908	0	Survivin	0,8	p53	23,26	Survivin	p53	11799(Tax:10090)	7157	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	Survivin repression by p53 , Rb and E2F2 in normal human melanocytes .
26480818	0	Sushi_Domain-Containing_Protein_4	31,64	SUSD4	66,71	Sushi Domain-Containing Protein 4	SUSD4	55061	55061	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The human complement inhibitor Sushi_Domain-Containing_Protein_4 -LRB- SUSD4 -RRB- expression in tumor cells and infiltrating T cells is associated with better prognosis of breast_cancer patients .
15935772	0	Susi	0,4	PI3-kinase	41,51	Susi	PI3-kinase	34767(Tax:7227)	33203(Tax:7227)	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Susi , a negative regulator of Drosophila PI3-kinase .
26031938	0	Swa2	0,4	auxilin	37,44	Swa2	auxilin	851918(Tax:4932)	9829	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Swa2 , the yeast homolog of mammalian auxilin , is specifically required for the propagation of the prion variant -LSB- URE3-1 -RSB- .
9716410	0	Swe1	92,96	Cdc34	0,5	Swe1	Cdc34	853252(Tax:4932)	851624(Tax:4932)	Gene	Gene	degradation|nmod|START_ENTITY required|nmod|degradation required|nsubjpass|END_ENTITY	Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1 .
10490630	0	Swe1p	80,85	Hsl1p	101,106	Swe1p	Hsl1p	853252(Tax:4932)	853760(Tax:4932)	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	The morphogenesis checkpoint in Saccharomyces_cerevisiae : cell cycle control of Swe1p degradation by Hsl1p and Hsl7p .
8007977	0	Swi4	8,12	CLN2	41,45	Swi4	CLN2	856847(Tax:4932)	855819(Tax:4932)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Role of Swi4 in cell cycle regulation of CLN2 expression .
8649372	0	Swi4	65,69	Swi6	191,195	Swi4	Swi6	856847(Tax:4932)	850879(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Saccharomyces_cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6 .
8649372	0	Swi6	191,195	Swi4	65,69	Swi6	Swi4	850879(Tax:4932)	856847(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Saccharomyces_cerevisiae Start-specific transcription factor Swi4 interacts through the ankyrin repeats with the mitotic Clb2/Cdc28 kinase and through its conserved carboxy terminus with Swi6 .
21829374	0	Sxl	104,107	eIF4E	34,39	Sxl	eIF4E	3772180(Tax:7227)	45525(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila_melanogaster .
21220321	0	Sxl-Pe	103,109	Sex-lethal	68,78	Sxl-Pe	Sex-lethal	3772180(Tax:7227)	3772180(Tax:7227)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	The Drosophila Myc gene , diminutive , is a positive regulator of the Sex-lethal establishment promoter , Sxl-Pe .
10940022	0	SycE	104,108	YopE	137,141	SycE	YopE	1449492(Tax:630)	1449493(Tax:630)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Competition between the Yops of Yersinia_enterocolitica for delivery into eukaryotic cells : role of the SycE chaperone binding domain of YopE .
8497188	0	SycE	0,4	YopE	87,91	SycE	YopE	1449492(Tax:630)	1449493(Tax:630)	Gene	Gene	involved|advmod|START_ENTITY involved|nmod|secretion secretion|nmod|END_ENTITY	SycE , a chaperone-like protein of Yersinia_enterocolitica involved in Ohe secretion of YopE .
23684705	0	Syk	14,17	Bcl-2	21,26	Syk	Bcl-2	6850	596	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation by Syk of Bcl-2 , calcium and the calpain-calpastatin proteolytic system in human breast_cancer cells .
20154219	0	Syk	17,20	CLEC-2	0,6	Syk	CLEC-2	6850	51266	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	CLEC-2 activates Syk through dimerization .
21728173	0	Syk	21,24	CLEC-2	0,6	Syk	CLEC-2	20963(Tax:10090)	56760(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses .
16148119	0	Syk	0,3	CX3CL1	54,60	Syk	CX3CL1	6850	6376	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Syk is required for monocyte/macrophage chemotaxis to CX3CL1 -LRB- Fractalkine -RRB- .
10540342	0	Syk	8,11	Cbl	69,72	Syk	Cbl	100716985	100725041	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Role of Syk in Fc gamma receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C. Fcgamma receptors -LRB- FcgammaR -RRB- of guinea_pig neutrophils were ligated and anti-Cbl immunoprecipitates prepared therefrom were assayed for the associated protein tyrosine kinase activity , which increased upon ligation of FcgammaR .
10617633	0	Syk	74,77	Cbl	26,29	Syk	Cbl	6850	867	Gene	Gene	kinase|compound|START_ENTITY regulation|nmod|kinase essential|nmod|regulation essential|nsubj|domain domain|nmod|END_ENTITY	The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase .
19419964	0	Syk	0,3	Cbl	114,117	Syk	Cbl	6850	867	Gene	Gene	tyrosine|compound|START_ENTITY regulates|nsubj|tyrosine regulates|dobj|function function|nmod|activity activity|nmod|END_ENTITY	Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl .
9880513	0	Syk	79,82	Cbl	118,121	Syk	Cbl	6850	867	Gene	Gene	association|nmod|START_ENTITY substrates|nsubj|association substrates|dobj|END_ENTITY	Phosphorylation - and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells .
18200499	0	Syk	0,3	Dectin-1	77,85	Syk	Dectin-1	6850	64581	Gene	Gene	kinase|compound|START_ENTITY required|nsubjpass|kinase required|nmod|production production|acl|induced induced|nmod|receptors receptors|amod|END_ENTITY	Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors .
22633994	0	Syk	9,12	Dectin-1	0,8	Syk	Dectin-1	20963(Tax:10090)	56644(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY involved|nsubjpass|signaling END_ENTITY|parataxis|involved	Dectin-1 / Syk signaling is involved in Lactobacillus casei cell wall extract-induced mouse model of Kawasaki_disease .
15337524	0	Syk	24,27	EGFR	38,42	Syk	EGFR	6850	1956	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells .
16456001	0	Syk	54,57	Grb2-associated_binder_2	20,44	Syk	Grb2-associated binder 2	6850	9846	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Scaffolding adapter Grb2-associated_binder_2 requires Syk to transmit signals from FcepsilonRI .
26708990	0	Syk	0,3	IFNb	39,43	Syk	IFNb	20963(Tax:10090)	15977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Syk negatively regulates TLR4-mediated IFNb and IL-10 production and promotes inflammatory responses in dendritic cells .
9395328	0	Syk	24,27	Interleukin-3	0,13	Syk	Interleukin-3	6850	3562	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-3 activates Syk in a human myeloblastic_leukemia cell line , AML193 .
8001675	0	Syk	46,49	N-acetyl-L-cysteine	0,19	Syk	N-acetyl-L-cysteine	6850	7504	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	N-acetyl-L-cysteine inhibits antigen-mediated Syk , but not Lyn tyrosine kinase activation in mast cells .
19581935	0	Syk	20,23	PKCdelta	95,103	Syk	PKCdelta	6850	5580	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The tyrosine kinase Syk regulates the survival of chronic_lymphocytic_leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression .
26381330	0	Syk	42,45	Spleen_Tyrosine_Kinase	18,40	Syk	Spleen Tyrosine Kinase	6850	6850	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Imidazotriazines : Spleen_Tyrosine_Kinase -LRB- Syk -RRB- Inhibitors Identified by Free-Energy Perturbation -LRB- FEP -RRB- .
9464827	0	Syk	24,27	Thy-1	43,48	Syk	Thy-1	25155(Tax:10116)	24832(Tax:10116)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic_leukemia cells .
16882714	0	Syk	57,60	Vav	4,7	Syk	Vav	6850	7409	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin -LRB- CD11/CD18 -RRB- - mediated neutrophil migration .
12763134	0	Syk	92,95	ZAP-70	103,109	Syk	ZAP-70	6850	7535	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression .
18818389	0	Syk	48,51	dectin-1	39,47	Syk	dectin-1	20963(Tax:10090)	56644(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Stimulation of dendritic cells via the dectin-1 / Syk pathway allows priming of cytotoxic T-cell responses .
23817424	0	Syk	111,114	dectin-1	102,110	Syk	dectin-1	6850	64581	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Corticosteroids block autophagy protein recruitment in Aspergillus_fumigatus phagosomes via targeting dectin-1 / Syk kinase signaling .
10643150	0	Syk	49,52	granulocyte_colony-stimulating_factor	62,99	Syk	granulocyte colony-stimulating factor	6850	1440	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte_colony-stimulating_factor receptor -LRB- G-CSFR -RRB- is not abrogated in neutrophils from severe congenital_neutropenia patients with point mutations in the G-CSFR mRNA .
17543554	0	Syk	23,26	intercellular_adhesion_molecule-1	108,141	Syk	intercellular adhesion molecule-1	20963(Tax:10090)	15894(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|advcl|END_ENTITY	Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha -LRB- L -RRB- beta -LRB- 2 -RRB- integrin-mediated rolling on intercellular_adhesion_molecule-1 .
12215219	0	Syk	0,3	p38	20,23	Syk	p38	6850	1432	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	Syk is required for p38 activation and G2/M arrest in B cells exposed to oxidative stress .
9218456	0	Syk	0,3	p90Rsk	47,53	Syk	p90Rsk	427272(Tax:9031)	386579(Tax:9031)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Syk is required for BCR-mediated activation of p90Rsk , but not p70S6k , via a mitogen-activated protein kinase-independent pathway in B cells .
26154322	0	Syk	38,41	spleen_tyrosine_kinase	14,36	Syk	spleen tyrosine kinase	6850	6850	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of spleen_tyrosine_kinase -LRB- Syk -RRB- at fertilization in Rhinella arenarum eggs .
17558405	0	SynCAM4	26,33	Necl4	19,24	SynCAM4	Necl4	199731	199731	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A central role for Necl4 -LRB- SynCAM4 -RRB- in Schwann cell-axon interaction and myelination .
25843720	0	Synapsin_III	0,12	Semaphorin_3A	32,45	Synapsin III	Semaphorin 3A	8224	10371	Gene	Gene	Downstream|compound|START_ENTITY Downstream|nmod|END_ENTITY	Synapsin_III Acts Downstream of Semaphorin_3A / CDK5 Signaling to Regulate Radial Migration and Orientation of Pyramidal Neurons In Vivo .
15228590	0	Synaptic_scaffolding_molecule	0,29	axin	45,49	Synaptic scaffolding molecule	axin	113970(Tax:10116)	79257(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Synaptic_scaffolding_molecule interacts with axin .
14622578	0	Synaptojanin	0,12	endophilin	29,39	Synaptojanin	endophilin	37517(Tax:7227)	42265(Tax:7227)	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating .
25425624	0	Synaptopodin	43,55	STAT3	0,5	Synaptopodin	STAT3	104027(Tax:10090)	20848(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	STAT3 Regulates Steady-State Expression of Synaptopodin in Cultured Mouse Podocytes .
8087843	0	Synaptotagmin_I	0,15	AP-2	57,61	Synaptotagmin I	AP-2	6857	7020	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Synaptotagmin_I is a high affinity receptor for clathrin AP-2 : implications for membrane recycling .
17307723	0	Synaptotagmin_I	0,15	NHE3	44,48	Synaptotagmin I	NHE3	20979(Tax:10090)	105243(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Synaptotagmin_I binds intestinal epithelial NHE3 and mediates cAMP - and Ca2 + - induced endocytosis by recruitment of AP2 and clathrin .
23177091	0	Syncytin-2	12,22	MFSD2a	0,6	Syncytin-2	MFSD2a	405754	84879	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	MFSD2a , the Syncytin-2 receptor , is important for trophoblast fusion .
11598177	0	Syndecan-1	0,10	CD138	12,17	Syndecan-1	CD138	6382	6382	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Syndecan-1 -LRB- CD138 -RRB- immunoreactivity in bone marrow biopsies of multiple myeloma : shed syndecan-1 accumulates in fibrotic regions .
24722758	0	Syndecan-1	21,31	MicroRNA-143	0,12	Syndecan-1	MicroRNA-143	6382	406935	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-143 targets Syndecan-1 to repress cell growth in melanoma .
16945147	0	Syndecan-1	0,10	lipoprotein_receptor-related_protein	71,107	Syndecan-1	lipoprotein receptor-related protein	6382	4035	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- - independent , non-clathrin-mediated pathway .
19539355	0	Syndecan-1	0,10	nuclear_factor_kappaB	112,133	Syndecan-1	nuclear factor kappaB	6382	4790	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|modulating modulating|nmod|END_ENTITY	Syndecan-1 enhances the endometrial_cancer_invasion by modulating matrix_metalloproteinase-9 expression through nuclear_factor_kappaB .
22471946	0	Syndecan-2	0,10	K-ras	60,65	Syndecan-2	K-ras	6383	3845	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic_cancer cell phenotype .
22900087	0	Syndecan-2	0,10	insulin-like_growth_factor_binding_protein-3	32,76	Syndecan-2	insulin-like growth factor binding protein-3	6383	3486	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Syndecan-2 is a novel target of insulin-like_growth_factor_binding_protein-3 and is over-expressed in fibrosis .
19684582	0	Syndecan-4	0,10	ADAMTS-5	21,29	Syndecan-4	ADAMTS-5	20971(Tax:10090)	23794(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown_in_osteoarthritis .
15371457	0	Syndecan-4	0,10	ATF-2	21,26	Syndecan-4	ATF-2	6385	1386	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Syndecan-4 regulates ATF-2 transcriptional activity in a Rac1-dependent manner .
25491150	0	Syndecan-4	26,36	TNF-a	0,5	Syndecan-4	TNF-a	24771(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNF-a and TGF-b1 regulate Syndecan-4 expression in nucleus pulposus cells : role of the mitogen-activated protein kinase and NF-kB pathways .
12493766	0	Syndecan-4	0,10	alpha-actinin	27,40	Syndecan-4	alpha-actinin	6385	87	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Syndecan-4 associates with alpha-actinin .
11549250	0	Syndecan-4	0,10	antithrombin	14,26	Syndecan-4	antithrombin	6385	462	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Syndecan-4 as antithrombin receptor of human neutrophils .
12543640	0	Syndecan-4	0,10	fibroblast_growth_factor_2	27,53	Syndecan-4	fibroblast growth factor 2	20971(Tax:10090)	14173(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Syndecan-4 modulates basic fibroblast_growth_factor_2 signaling in vivo .
14670076	0	Syndecan-4	0,10	protein_kinase_C-alpha	61,83	Syndecan-4	protein kinase C-alpha	6385	5578	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Syndecan-4 regulates localization , activity and stability of protein_kinase_C-alpha .
22975683	0	Syndecan_4	0,10	Akt	40,43	Syndecan 4	Akt	6385	207	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Syndecan_4 regulation of PDK1-dependent Akt activation .
22569333	0	Syndecan_4	0,10	FGFR1	21,26	Syndecan 4	FGFR1	6385	2260	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Syndecan_4 regulates FGFR1 signaling in endothelial cells by directing macropinocytosis .
19853601	0	Synemin	0,7	zyxin	46,51	Synemin	zyxin	23336	7791	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration .
15753124	0	Synip	20,25	Akt2	0,4	Synip	Akt2	252983	208	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles .
24459464	0	Syntaxin-11	69,80	FHL4	54,58	Syntaxin-11	FHL4	8676	8676	Gene	Gene	Binding|compound|START_ENTITY Binding|compound|END_ENTITY	An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2 .
23315993	0	Syntaxin-1a	0,11	miR-29a	34,41	Syntaxin-1a	miR-29a	6804	407021	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Syntaxin-1a is a direct target of miR-29a in insulin-producing b-cells .
24055037	0	Syntaxin-4	0,10	IgE	28,31	Syntaxin-4	IgE	6810	3497	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Syntaxin-4 is essential for IgE secretion by plasma cells .
10036234	0	Syntaxin_11	0,11	SNAP-23	31,38	Syntaxin 11	SNAP-23	8676	8773	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Syntaxin_11 is associated with SNAP-23 on late endosomes and the trans-Golgi network .
26709266	0	Syntaxin_11	8,19	STX11	26,31	Syntaxin 11	STX11	8676	8676	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	A Novel Syntaxin_11 Gene -LRB- STX11 -RRB- Mutation c. 650T > C , p.Leu217Pro , in a Korean Child With Familial_Hemophagocytic_Lymphohistiocytosis .
21388490	0	Syntaxin_11	0,11	Vti1b	18,23	Syntaxin 11	Vti1b	8676	10490	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Syntaxin_11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages .
20826815	0	Syntaxin_16	0,11	cystic_fibrosis_transmembrane_conductance_regulator	21,72	Syntaxin 16	cystic fibrosis transmembrane conductance regulator	362283(Tax:10116)	24255(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Syntaxin_16 binds to cystic_fibrosis_transmembrane_conductance_regulator and regulates its membrane trafficking in epithelial cells .
18617632	0	Syntaxin_1A	0,11	dopamine_transporter	33,53	Syntaxin 1A	dopamine transporter	6804	6531	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Syntaxin_1A interaction with the dopamine_transporter promotes amphetamine-induced dopamine efflux .
20643191	0	Syntaxin_1A	0,11	dopamine_transporter	22,42	Syntaxin 1A	dopamine transporter	116470(Tax:10116)	24898(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Syntaxin_1A regulates dopamine_transporter activity , phosphorylation and surface expression .
25593999	0	Syntenin	6,14	MDA-9	0,5	Syntenin	MDA-9	6386	6386	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	MDA-9 / Syntenin regulates differentiation and angiogenesis programs in head_and_neck_squamous_cell_carcinoma .
18234474	0	Syntenin	0,8	TLR4	51,55	Syntenin	TLR4	6386	7099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Syntenin negatively regulates TRAF6-mediated IL-1R / TLR4 signaling .
17308124	0	Syntenin	6,14	mda-9	0,5	Syntenin	mda-9	6386	6386	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	mda-9 / Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear_factor-kappaB .
18832467	0	Syntenin	6,14	mda-9	0,5	Syntenin	mda-9	6386	6386	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	mda-9 / Syntenin promotes metastasis in human melanoma cells by activating c-Src .
12115002	0	Syp	0,3	Grb2	53,57	Syp	Grb2	6855	2885	Gene	Gene	Mediate|nsubj|START_ENTITY Mediate|nmod|END_ENTITY	Syp Y279 , Y304 Can Mediate the Binding of Bcr-Abl to Grb2 and Other Proteins .
26179915	0	Syp1	62,66	Rho1	0,4	Syp1	Rho1	850396(Tax:4932)	856294(Tax:4932)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Rho1 - and Pkc1-dependent phosphorylation of the F-BAR protein Syp1 contributes to septin ring assembly .
20841378	0	Syt1p	0,5	Imh1p	64,69	Syt1p	Imh1p	856210(Tax:4932)	851018(Tax:4932)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p .
20811643	0	Syx	13,16	Rnd3	32,36	Syx	Rnd3	269608(Tax:10090)	74194(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain .
7679169	0	T-0509	53,59	beta_1-adrenoceptor	73,92	T-0509	beta 1-adrenoceptor	1069472(Tax:209261)	153	Gene	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	ICI_147 ,798 causes insurmountable antagonism against T-0509 , a selective beta_1-adrenoceptor agonist , but surmountable antagonism against isoproterenol .
11137871	0	T-1032	27,33	phosphodiesterase_type_5	52,76	T-1032	phosphodiesterase type 5	1070362(Tax:209261)	171115(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Pharmacological profile of T-1032 , a novel specific phosphodiesterase_type_5 inhibitor , in isolated rat aorta and rabbit corpus cavernosum .
11430921	0	T-1032	0,6	phosphodiesterase_type_5	25,49	T-1032	phosphodiesterase type 5	1070362(Tax:209261)	171115(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	T-1032 , a novel specific phosphodiesterase_type_5 inhibitor , increases venous compliance in anesthetized rats .
12419952	0	T-1032	29,35	phosphodiesterase_type_5	55,79	T-1032	phosphodiesterase type 5	1070362(Tax:209261)	171115(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Acute and chronic effects of T-1032 , a novel selective phosphodiesterase_type_5 inhibitor , on monocrotaline-induced pulmonary_hypertension in rats .
25352127	0	T-BET	68,73	TOX2	0,4	T-BET	TOX2	30009	84969	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	TOX2 regulates human natural killer cell development by controlling T-BET expression .
19698128	0	T-Bet	51,56	CD4	71,74	T-Bet	CD4	30009	920	Gene	Gene	Modulation|appos|START_ENTITY Modulation|nmod|cells cells|nummod|END_ENTITY	Modulation of cytokines and transcription factors -LRB- T-Bet and GATA3 -RRB- in CD4 enriched cervical cells of Chlamydia_trachomatis infected fertile and infertile women upon stimulation with chlamydial inclusion membrane proteins B and C. BACKGROUND : Chlamydial Inclusion membrane proteins -LRB- Incs -RRB- , are involved in biochemical interactions with host cells and infecting Chlamydiae .
24778280	0	T-Bet	61,66	CD4	0,3	T-Bet	CD4	30009	920	Gene	Gene	expression|amod|START_ENTITY increase|dobj|expression signaling|xcomp|increase PI3K|acl|signaling require|dobj|PI3K require|nsubj|cells cells|compound|END_ENTITY	CD4 T cells require ICOS-mediated PI3K signaling to increase T-Bet expression in the setting of anti-CTLA-4 therapy .
26714260	0	T-Bet	28,33	CD8	53,56	T-Bet	CD8	30009	925	Gene	Gene	Ratio|nmod|START_ENTITY Regulates|dobj|Ratio Regulates|nmod|Eomesodermin Eomesodermin|nmod|Cells Cells|compound|END_ENTITY	IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8 + T Cells Responding to Persistent LCMV Infection .
20647304	0	T-LAK_cell-originated_protein_kinase	0,36	Prx1	162,166	T-LAK cell-originated protein kinase	Prx1	55872	5052	Gene	Gene	phosphorylation|amod|START_ENTITY prevents|nsubj|phosphorylation prevents|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
20647304	0	T-LAK_cell-originated_protein_kinase	0,36	Prx1	63,67	T-LAK cell-originated protein kinase	Prx1	55872	5052	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
20647304	0	T-LAK_cell-originated_protein_kinase	0,36	TOPK	38,42	T-LAK cell-originated protein kinase	TOPK	55872	55872	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
21715333	0	T-LAK_cell-originated_protein_kinase	0,36	TOPK	38,42	T-LAK cell-originated protein kinase	TOPK	52033(Tax:10090)	52033(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway .
27021296	0	T-bet	5,10	CCR5	0,4	T-bet	CCR5	57765(Tax:10090)	12774(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
11786644	0	T-bet	20,25	CD4	80,83	T-bet	CD4	30009	920	Gene	Gene	effects|nmod|START_ENTITY lineage|nsubj|effects lineage|dobj|production production|nmod|cells cells|compound|END_ENTITY	Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells .
16014561	0	T-bet	0,5	CD4	46,49	T-bet	CD4	30009	920	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|trafficking trafficking|compound|END_ENTITY	T-bet is required for optimal proinflammatory CD4 + T-cell trafficking .
16177105	0	T-bet	14,19	CD4	23,26	T-bet	CD4	57765(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of T-bet by CD4 T cells is essential for resistance to Salmonella_infection .
16861655	0	T-bet	29,34	CD4	49,52	T-bet	CD4	57765(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Role of transcription factor T-bet expression by CD4 + cells in gastritis due to Helicobacter_pylori in mice .
18414429	0	T-bet	103,108	CD4	23,26	T-bet	CD4	30009	920	Gene	Gene	expression|nmod|START_ENTITY alterations|nmod|expression modulate|nmod|alterations modulate|dobj|response response|compound|END_ENTITY	Prolactin can modulate CD4 + T-cell response through receptor-mediated alterations in the expression of T-bet .
19414771	0	T-bet	0,5	CD4	64,67	T-bet	CD4	57765(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|cells cells|amod|in in|dep|differentiation differentiation|nmod|Th17 Th17|compound|END_ENTITY	T-bet inhibits the in vivo differentiation of parasite-specific CD4 + Th17 cells in a T cell-intrinsic manner .
19923468	0	T-bet	95,100	CD4	121,124	T-bet	CD4	30009	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4 + T cells .
21177324	0	T-bet	4,9	CD4	0,3	T-bet	CD4	30009	920	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	CD4 + T-bet + , CD4 + pSTAT3 + and CD8 + T-bet + T cells accumulate in peripheral blood during NZB treatment .
21690296	0	T-bet	47,52	CD4	82,85	T-bet	CD4	57765(Tax:10090)	12504(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY phosphorylation|nmod|domain regulates|nsubj|phosphorylation regulates|dobj|T-cell T-cell|compound|END_ENTITY	c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4 + T-cell differentiation and allergic_lung_inflammation .
23509355	0	T-bet	8,13	CD4	43,46	T-bet	CD4	30009	920	Gene	Gene	dominance|amod|START_ENTITY dominance|nmod|END_ENTITY	Altered T-bet dominance in IFN-y-decoupled CD4 + T cells with attenuated cytokine storm and preserved memory in influenza .
25378399	0	T-bet	74,79	CD4	29,32	T-bet	CD4	30009	920	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Human Memory , but Not Naive , CD4 + T Cells Expressing Transcription Factor T-bet Might Drive Rapid Cytokine Production .
25495780	0	T-bet	13,18	CD4	88,91	T-bet	CD4	30009	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|Mart-127-35 Mart-127-35|dep|CD25 CD25|compound|END_ENTITY	Knockdown of T-bet expression in Mart-127-35 - specific T-cell-receptor-engineered human CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- and CD8 -LRB- + -RRB- T cells attenuates effector function .
27021296	0	T-bet	5,10	CD4	27,30	T-bet	CD4	57765(Tax:10090)	12504(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
15096540	0	T-bet	0,5	CD8	30,33	T-bet	CD8	30009	925	Gene	Gene	controls|amod|START_ENTITY autoaggressive|nsubj|controls autoaggressive|dobj|responses responses|nummod|END_ENTITY	T-bet controls autoaggressive CD8 lymphocyte responses in type_1_diabetes .
17723210	0	T-bet	55,60	CD8	0,3	T-bet	CD8	30009	925	Gene	Gene	choosing|nmod|START_ENTITY T|parataxis|choosing T|nsubj|END_ENTITY	CD8 -LRB- + -RRB- T cell differentiation : choosing a path through T-bet .
21177324	0	T-bet	32,37	CD8	28,31	T-bet	CD8	30009	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + T-bet + , CD4 + pSTAT3 + and CD8 + T-bet + T cells accumulate in peripheral blood during NZB treatment .
21289310	0	T-bet	99,104	CD8	23,26	T-bet	CD8	30009	925	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|potential potential|compound|END_ENTITY	Increased HIV-specific CD8 + T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression .
23440501	0	T-bet	10,15	CD8	74,77	T-bet	CD8	30009	925	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|senescence senescence|nmod|cells cells|compound|END_ENTITY	Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans .
23455505	0	T-bet	29,34	CD8	48,51	T-bet	CD8	30009	925	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|populations populations|compound|END_ENTITY	Differential localization of T-bet and Eomes in CD8 T cell memory populations .
23479229	0	T-bet	62,67	CD8	15,18	T-bet	CD8	30009	925	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	IL-21 promotes CD8 + CTL activity via the transcription factor T-bet .
25225458	0	T-bet	96,101	CD8	14,17	T-bet	CD8	30009	925	Gene	Gene	induction|amod|START_ENTITY lack|nmod|induction characterized|nmod|lack characterized|nsubjpass|cells cells|compound|END_ENTITY	Dysfunctional CD8 + T cells in hepatitis_B and C are characterized by a lack of antigen-specific T-bet induction .
25516478	0	T-bet	44,49	CD8	114,117	T-bet	CD8	30009	925	Gene	Gene	relies|nmod|START_ENTITY relies|xcomp|induce induce|nmod|cells cells|compound|END_ENTITY	Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8 + T cells .
24760151	0	T-bet	67,72	Ezh2	0,4	T-bet	Ezh2	57765(Tax:10090)	14056(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic_anemia in mice .
27021296	0	T-bet	5,10	FoxP3	11,16	T-bet	FoxP3	57765(Tax:10090)	20371(Tax:10090)	Gene	Gene	Drive|compound|START_ENTITY Drive|compound|END_ENTITY	CCR5 + T-bet + FoxP3 + Effector CD4 T Cells Drive Atherosclerosis .
25219397	0	T-bet	0,5	Foxp3	35,40	T-bet	Foxp3	57765(Tax:10090)	20371(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|differentiation differentiation|nmod|cells cells|amod|END_ENTITY	T-bet regulates differentiation of Foxp3 -LRB- + -RRB- regulatory T cells in programmed_cell_death-1-deficient mice .
25741342	0	T-bet	0,5	Foxp3	20,25	T-bet	Foxp3	57765(Tax:10090)	20371(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	T-bet Expression by Foxp3 -LRB- + -RRB- T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune_Disease or Colitis .
25757968	0	T-bet	72,77	GATA-3	80,86	T-bet	GATA-3	100518804	733631(Tax:9823)	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|dep|END_ENTITY	-LSB- Effects of Shenfu injection on the expression of transcription factors T-bet / GATA-3 in pigs with post-resuscitation myocardial_dysfunction -RSB- .
25069192	0	T-bet	91,96	GATA-binding_protein_3	98,120	T-bet	GATA-binding protein 3	57765(Tax:10090)	14462(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	-LSB- Effects of needle pricking therapy of Zhuang minority medicine on expression of pulmonary T-bet , GATA-binding_protein_3 genes and thymic_stromal_lymphopoietin protein in the lung of asthma mice -RSB- .
17308068	0	T-bet	34,39	Interleukin-18	0,14	T-bet	Interleukin-18	30009	3606	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-kappaB in acute_myeloid_leukemia-derived predendritic KG-1 cells .
20131264	0	T-bet	59,64	Interleukin-23	0,14	T-bet	Interleukin-23	57765(Tax:10090)	83430(Tax:10090)	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22 , but not interleukin-21 , in autoimmune experimental arthritis .
18418398	0	T-bet	54,59	OC2	28,31	T-bet	OC2	30009	9480	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells .
21623380	0	T-bet	21,26	PD-1	75,79	T-bet	PD-1	30009	5133	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8 + T cell responses during chronic_infection .
12816998	0	T-bet	70,75	Peroxisome_proliferator-activated_receptor_alpha	0,48	T-bet	Peroxisome proliferator-activated receptor alpha	57765(Tax:10090)	19013(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation .
24006458	0	T-bet	23,28	STAT5	7,12	T-bet	STAT5	57765(Tax:10090)	20850(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6 / TGF-b1 signaling .
22909160	0	T-bet	8,13	STAT6	38,43	T-bet	STAT6	30009	6778	Gene	Gene	START_ENTITY|nmod|addition addition|nmod|END_ENTITY	Reduced T-bet in addition to enhanced STAT6 and GATA3 expressing T cells contribute to human allergen-induced late responses .
18993086	0	T-bet	92,97	Signal_transducer_and_activator_of_transcription_4	0,50	T-bet	Signal transducer and activator of transcription 4	30009	6775	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Signal_transducer_and_activator_of_transcription_4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination .
24499286	0	T-bet	121,126	TBX21	114,119	T-bet	TBX21	57765(Tax:10090)	57765(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor , TBX21 -LRB- T-bet -RRB- .
16237056	0	T-bet	19,24	TGF-beta1	0,9	T-bet	TGF-beta1	57765(Tax:10090)	21803(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4 + T cells through the protein tyrosine phosphatase Src_homology_region_2_domain-containing_phosphatase-1 .
11397944	0	T-bet	8,13	TH1	31,34	T-bet	TH1	30009	51497	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|cells cells|nummod|END_ENTITY	Role of T-bet in commitment of TH1 cells before IL-12-dependent selection .
12171942	0	T-bet	0,5	Th1	18,21	T-bet	Th1	30009	51497	Gene	Gene	responses|amod|START_ENTITY responses|compound|END_ENTITY	T-bet and mucosal Th1 responses in the gastrointestinal tract .
12734330	0	T-bet	61,66	WSX-1	28,33	T-bet	WSX-1	30009	9466	Gene	Gene	induction|nmod|START_ENTITY signaling|nmod|induction signaling|nsubj|END_ENTITY	Cutting edge : role of IL-27 / WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment .
17215482	0	T-bet	72,77	glucocorticoid_receptor	14,37	T-bet	glucocorticoid receptor	30009	2908	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The activated glucocorticoid_receptor inhibits the transcription factor T-bet by direct protein-protein interaction .
11752460	0	T-bet	0,5	interferon-gamma	28,44	T-bet	interferon-gamma	57765(Tax:10090)	15978(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells .
19123327	0	T-bet	115,120	interferon-gamma	57,73	T-bet	interferon-gamma	30009	3458	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|procyanidins procyanidins|nmod|expressions expressions|nmod|factor factor|amod|END_ENTITY	-LSB- Regulatory effect of procyanidins on the expressions of interferon-gamma , interleukin-12 and transcription factor T-bet mRNA in peripheral blood mononuclear cell of patients with alopecia_areata -RSB- .
19186970	0	T-bet	52,57	interferon-gamma	10,26	T-bet	interferon-gamma	30009	3458	Gene	Gene	START_ENTITY|nsubj|Levels Levels|nmod|factor factor|compound|END_ENTITY	Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic_periodontitis .
19757302	0	T-bet	28,33	interferon-gamma	104,120	T-bet	interferon-gamma	30009	3458	Gene	Gene	T-box-expressed-in-T-cells|appos|START_ENTITY expression|nsubj|T-box-expressed-in-T-cells expression|nmod|production production|amod|END_ENTITY	T-box-expressed-in-T-cells -LRB- T-bet -RRB- expression by the tumor cells of hairy-cell_leukemia correlates with interferon-gamma production .
20348948	0	T-box_2	0,7	NDRG1	18,23	T-box 2	NDRG1	6909	10397	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	T-box_2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast_cancer cells .
27026770	0	T-box_transcription_factor-5	32,60	TBX-5	62,67	T-box transcription factor-5	TBX-5	6910	6910	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutated sequence in the T-box_transcription_factor-5 -LRB- TBX-5 -RRB- gene -LRB- c. 241A > T -RRB- in Holt-Oram_syndrome .
17874043	0	T-cadherin	77,87	Adiponectin	0,11	T-cadherin	Adiponectin	1012	9370	Gene	Gene	receptor|appos|START_ENTITY role|nmod|receptor receptors|nmod|role receptors|nsubj|END_ENTITY	Adiponectin receptors , with special focus on the role of the third receptor , T-cadherin , in vascular_disease .
10737605	0	T-cadherin	14,24	CDH13	26,31	T-cadherin	CDH13	1012	1012	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of T-cadherin -LRB- CDH13 , H-Cadherin -RRB- in human brain and its characteristics as a negative growth regulator of epidermal_growth_factor in neuroblastoma cells .
11355171	0	T-cadherin	0,10	CDH13	12,17	T-cadherin	CDH13	1012	1012	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	T-cadherin -LRB- CDH13 , H-cadherin -RRB- expression downregulated surfactant_protein_D in bronchioloalveolar cells .
12177241	0	T-cadherin	8,18	CDH13	20,25	T-cadherin	CDH13	1012	1012	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of T-cadherin -LRB- CDH13 , H-cadherin -RRB- expression in cutaneous_squamous_cell_carcinoma .
19463088	0	T-cadherin	0,10	Rac1	21,25	T-cadherin	Rac1	1012	5879	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	T-cadherin activates Rac1 and Cdc42 and changes endothelial permeability .
15703273	0	T-cadherin	77,87	RhoA	0,4	T-cadherin	RhoA	1012	387	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	RhoA and Rac mediate endothelial cell polarization and detachment induced by T-cadherin .
16273386	0	T-cadherin	164,174	adiponectin	3,14	T-cadherin	adiponectin	1012	9370	Gene	Gene	pathways|amod|START_ENTITY talk|nmod|pathways cells|dep|talk expressed|nmod|cells expressed|nsubjpass|receptor receptor|compound|END_ENTITY	An adiponectin receptor , T-cadherin , was selectively expressed in intratumoral capillary endothelial cells in hepatocellular_carcinoma : possible cross talk between T-cadherin and FGF-2 pathways .
16273386	0	T-cadherin	25,35	adiponectin	3,14	T-cadherin	adiponectin	1012	9370	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	An adiponectin receptor , T-cadherin , was selectively expressed in intratumoral capillary endothelial cells in hepatocellular_carcinoma : possible cross talk between T-cadherin and FGF-2 pathways .
22065538	0	T-cadherin	18,28	adiponectin	61,72	T-cadherin	adiponectin	1012	9370	Gene	Gene	influences|nsubj|START_ENTITY influences|dobj|variations variations|nmod|levels levels|compound|END_ENTITY	CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population .
11355171	0	T-cadherin	0,10	surfactant_protein_D	56,76	T-cadherin	surfactant protein D	1012	6441	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	T-cadherin -LRB- CDH13 , H-cadherin -RRB- expression downregulated surfactant_protein_D in bronchioloalveolar cells .
11880152	0	T-cell-growth-factor	56,76	IL-2	104,108	T-cell-growth-factor	IL-2	116562(Tax:10116)	116562(Tax:10116)	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	Propagation of lewis rat encephalitogenic T cell lines : T-cell-growth-factor is superior to recombinant IL-2 .
10752626	0	T-cell-specific_adapter_protein	29,60	SH2D2A	4,10	T-cell-specific adapter protein	SH2D2A	9047	9047	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	The SH2D2A gene encoding the T-cell-specific_adapter_protein -LRB- TSAd -RRB- is localized centromeric to the CD1 gene cluster on human Chromosome 1 .
22982397	0	T-cell_acute_leukemia_1	0,23	erythropoietin_receptor	45,68	T-cell acute leukemia 1	erythropoietin receptor	6886	2057	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	T-cell_acute_leukemia_1 -LRB- TAL1 -RRB- regulation of erythropoietin_receptor and association with excessive erythrocytosis .
22547929	0	T-cell_antigen_receptor	53,76	EpCAM	106,111	T-cell antigen receptor	EpCAM	846	4072	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of a fully human chimeric T-cell_antigen_receptor for tumor-associated antigen EpCAM .
15002043	0	T-cell_death-associated_gene_51	14,45	TDAG51	47,53	T-cell death-associated gene 51	TDAG51	22822	22822	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Regulation of T-cell_death-associated_gene_51 -LRB- TDAG51 -RRB- expression in human T-cells .
26459757	0	T-cell_factor	123,136	Beta-catenin	0,12	T-cell factor	Beta-catenin	3172	1499	Gene	Gene	sites|amod|START_ENTITY up-regulates|nmod|sites up-regulates|nsubj|END_ENTITY	Beta-catenin up-regulates the constitutive and virus-induced transcriptional capacity of the interferon-b promoter through T-cell_factor binding sites .
23068607	0	T-cell_factor	52,65	b-catenin	66,75	T-cell factor	b-catenin	3172	1499	Gene	Gene	/|compound|START_ENTITY signaling|nsubj|/ signaling|dep|END_ENTITY	NDRG2 and PRA1 interact and synergistically inhibit T-cell_factor / b-catenin signaling .
10896949	0	T-cell_factor	88,101	beta-catenin	23,35	T-cell factor	beta-catenin	3172	1499	Gene	Gene	complex|compound|START_ENTITY formation|nmod|complex preventing|dobj|formation signaling|advcl|preventing END_ENTITY|acl|signaling	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
10896949	0	T-cell_factor	88,101	beta-catenin	75,87	T-cell factor	beta-catenin	3172	1499	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
17050667	0	T-cell_factor	18,31	beta-catenin	32,44	T-cell factor	beta-catenin	3172	1499	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Essential role of T-cell_factor / beta-catenin in regulation of Rad6B : a potential mechanism for Rad6B overexpression in breast_cancer cells .
15940627	0	T-cell_factor-4	62,77	beta-catenin	78,90	T-cell factor-4	beta-catenin	6934	1499	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Poly -LRB- ADP-ribose -RRB- _ polymerase-1 is a component of the oncogenic T-cell_factor-4 / beta-catenin complex .
6332315	0	T-cell_growth_factor	23,43	Cyclosporin_A	0,13	T-cell growth factor	Cyclosporin A	3558	1442	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Cyclosporin_A inhibits T-cell_growth_factor gene expression at the level of mRNA transcription .
6424951	0	T-cell_growth_factor	18,38	TCGF	40,44	T-cell growth factor	TCGF	443401(Tax:9940)	443401(Tax:9940)	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	The production of T-cell_growth_factor -LRB- TCGF -RRB- in vivo in sheep .
6609319	0	T-cell_growth_factor	18,38	TCGF	12,16	T-cell growth factor	TCGF	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of TCGF -LRB- T-cell_growth_factor -RRB- on experimental malignant_glioma-specific killer T-cell -RSB- .
17488725	0	T-cell_intracellular_antigen_1	20,50	TIA-1	52,57	T-cell intracellular antigen 1	TIA-1	7072	7072	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Two isoforms of the T-cell_intracellular_antigen_1 -LRB- TIA-1 -RRB- splicing factor display distinct splicing regulation activities .
16431927	0	T-cell_protein-tyrosine_phosphatase	150,185	Stat1	112,117	T-cell protein-tyrosine phosphatase	Stat1	5771	6772	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	The catalytic activity of the eukaryotic initiation factor-2alpha kinase PKR is required to negatively regulate Stat1 and Stat3 via activation of the T-cell_protein-tyrosine_phosphatase .
22159501	0	T-cell_protein_tyrosine_phosphatase	35,70	TCPTP	72,77	T-cell protein tyrosine phosphatase	TCPTP	5771	5771	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Potent and selective inhibition of T-cell_protein_tyrosine_phosphatase -LRB- TCPTP -RRB- by a dinuclear copper -LRB- II -RRB- complex .
23856547	0	T-cell_protein_tyrosine_phosphatase	23,58	TCPTP	60,65	T-cell protein tyrosine phosphatase	TCPTP	5771	5771	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	Molecular mechanism of T-cell_protein_tyrosine_phosphatase -LRB- TCPTP -RRB- activation by mitoxantrone .
9261175	0	T-cell_protein_tyrosine_phosphatase	19,54	p97	82,85	T-cell protein tyrosine phosphatase	p97	5771	4241	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the T-cell_protein_tyrosine_phosphatase with nuclear import factor p97 .
8367485	0	T-cell_receptor	37,52	CD4	68,71	T-cell receptor	CD4	6962	920	Gene	Gene	usage|amod|START_ENTITY usage|nmod|T-cell T-cell|compound|END_ENTITY	In vivo clonal dominance and limited T-cell_receptor usage in human CD4 + T-cell recognition of house dust mite allergens .
11133763	0	T-cell_receptor	25,40	CD8	53,56	T-cell receptor	CD8	6962	925	Gene	Gene	gene|amod|START_ENTITY analysis|nmod|gene use|nsubj|analysis use|nmod|T T|compound|END_ENTITY	Longitudinal analysis of T-cell_receptor gene use by CD8 -LRB- + -RRB- T cells in early human_immunodeficiency_virus_infection in patients receiving highly active antiretroviral therapy .
11157474	0	T-cell_receptor	177,192	CD8	210,213	T-cell receptor	CD8	6962	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Interferon-inducible_protein_10 , monokine_induced_by_interferon_gamma , and interferon-inducible_T-cell_alpha_chemoattractant are produced by thymic epithelial cells and attract T-cell_receptor -LRB- TCR -RRB- alphabeta + CD8 + single-positive T cells , TCRgammadelta + T cells , and natural killer-type cells in human thymus .
12888876	0	T-cell_receptor	81,96	CD8	127,130	T-cell receptor	CD8	6962	925	Gene	Gene	usage|amod|START_ENTITY usage|nmod|T-cell T-cell|compound|END_ENTITY	Replacement therapy with plasma-derived factor_VIII concentrates induces skew in T-cell_receptor usage and clonal expansion of CD8 + T-cell in HIV-seronegative hemophilia patients .
16367910	0	T-cell_receptor	73,88	CD8	105,108	T-cell receptor	CD8	6962	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Regulatory balance between the immune response of tumor antigen-specific T-cell_receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells .
16638844	0	T-cell_receptor	19,34	CD8	76,79	T-cell receptor	CD8	6962	925	Gene	Gene	profile|amod|START_ENTITY profile|nmod|T T|compound|END_ENTITY	Alterations in the T-cell_receptor variable beta gene-restricted profile of CD8 + T lymphocytes in the peripheral circulation of patients with squamous_cell_carcinoma_of_the_head_and_neck .
21606376	0	T-cell_receptor	30,45	CD8	85,88	T-cell receptor	CD8	6962	925	Gene	Gene	diversity|amod|START_ENTITY enabling|dobj|diversity enabling|nmod|END_ENTITY	Structural basis for enabling T-cell_receptor diversity within biased virus-specific CD8 + T-cell responses .
22898597	0	T-cell_receptor	0,15	CD8	51,54	T-cell receptor	CD8	6962	925	Gene	Gene	transfer|amod|START_ENTITY enhances|nsubj|transfer enhances|advmod|exclusively exclusively|nmod|cells cells|amod|human human|dep|END_ENTITY	T-cell_receptor gene transfer exclusively to human CD8 -LRB- + -RRB- cells enhances tumor cell killing .
24091848	0	T-cell_receptor	83,98	CD8	54,57	T-cell receptor	CD8	6962	925	Gene	Gene	cells|nmod|START_ENTITY T|dobj|cells T|nsubj|END_ENTITY	In vitro generation of mature , naive antigen-specific CD8 -LRB- + -RRB- T cells with a single T-cell_receptor by agonist selection .
24149287	0	T-cell_receptor	23,38	CD8	53,56	T-cell receptor	CD8	6962	925	Gene	Gene	repertoire|amod|START_ENTITY repertoire|nmod|lymphocyte_leukemia lymphocyte_leukemia|compound|END_ENTITY	Deep sequencing of the T-cell_receptor repertoire in CD8 + T-large granular lymphocyte_leukemia identifies signature landscapes .
27040081	0	T-cell_receptor	80,95	CD8	0,3	T-cell receptor	CD8	6962	925	Gene	Gene	sequencing|amod|START_ENTITY elucidated|nmod|sequencing elucidated|nsubj|T-cell T-cell|compound|END_ENTITY	CD8 -LRB- + -RRB- T-cell pathogenicity in Rasmussen_encephalitis elucidated by large-scale T-cell_receptor sequencing .
8381310	0	T-cell_receptor	105,120	CD8	22,25	T-cell receptor	CD8	6962	925	Gene	Gene	complex|compound|START_ENTITY expression|nmod|complex have|dobj|expression have|nsubj|cells cells|amod|Double-negative Double-negative|dep|CD4 CD4|dep|- -|compound|END_ENTITY	Double-negative -LRB- CD4 - CD8 - -RRB- T cells from adult_T-cell_leukemia patients also have poor expression of the T-cell_receptor alpha beta/CD3 complex .
8970681	0	T-cell_receptor	51,66	CD8	13,16	T-cell receptor	CD8	6962	925	Gene	Gene	usage|compound|START_ENTITY expansions|nmod|usage expansions|compound|END_ENTITY	Detection of CD8 T-cell expansions with restricted T-cell_receptor V gene usage in infants vertically infected by HIV-1 .
9744753	0	T-cell_receptor	28,43	CD8	125,128	T-cell receptor	CD8	6962	925	Gene	Gene	repertoires|amod|START_ENTITY analysis|nmod|repertoires analysis|dep|expansions expansions|compound|END_ENTITY	High-resolution analysis of T-cell_receptor beta-chain repertoires using DNA heteroduplex tracking : generally stable , clonal CD8 + expansions in all healthy young adults .
15623513	0	T-cell_receptor	76,91	HDAC7	33,38	T-cell receptor	HDAC7	328483(Tax:10090)	56233(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Protein_kinase_D1 phosphorylates HDAC7 and induces its nuclear export after T-cell_receptor activation .
14610621	0	T-cell_receptor	23,38	IL-2	39,43	T-cell receptor	IL-2	6962	3558	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	A soluble single-chain T-cell_receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity .
11157474	0	T-cell_receptor	177,192	TCR	194,197	T-cell receptor	TCR	6962	6962	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Interferon-inducible_protein_10 , monokine_induced_by_interferon_gamma , and interferon-inducible_T-cell_alpha_chemoattractant are produced by thymic epithelial cells and attract T-cell_receptor -LRB- TCR -RRB- alphabeta + CD8 + single-positive T cells , TCRgammadelta + T cells , and natural killer-type cells in human thymus .
17722993	0	T-cell_receptor	22,37	TCR	39,42	T-cell receptor	TCR	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Prolonged increase in T-cell_receptor -LRB- TCR -RRB- variant fractions of spleen T lymphocytes in pregnant mice after gamma irradiation .
17965552	0	T-cell_receptor	35,50	TCR	52,55	T-cell receptor	TCR	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Measurement of mutant_frequency in T-cell_receptor -LRB- TCR -RRB- gene by flow cytometry after X-irradiation on EL-4 mice lymphoma cells .
8320135	0	T-cell_receptor	34,49	TCR	51,54	T-cell receptor	TCR	6962	6962	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	A single universal primer for the T-cell_receptor -LRB- TCR -RRB- variable genes enables enzymatic amplification and direct sequencing of TCR beta cDNA of various T-cell clones .
21807895	0	T-cell_receptor	47,62	Tim-3	38,43	T-cell receptor	Tim-3	6962	84868	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Phosphotyrosine-dependent coupling of Tim-3 to T-cell_receptor signaling pathways .
19060239	0	T-cell_receptor	0,15	Vav1	34,38	T-cell receptor	Vav1	6962	7409	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	T-cell_receptor - and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue .
24164480	0	T-cell_receptor	108,123	Zap70	99,104	T-cell receptor	Zap70	328483(Tax:10090)	22637(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY END_ENTITY|nmod|signalling	A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell_receptor signalling .
7527866	0	T-cell_receptor	62,77	myelin_basic_protein	25,45	T-cell receptor	myelin basic protein	6962	4155	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	-LSB- Immune response against myelin_basic_protein and analysis of T-cell_receptor in multiple_sclerosis -RSB- .
2726770	0	T-cell_receptor_gamma-chain	21,48	Thy-1	70,75	T-cell receptor gamma-chain	Thy-1	110067(Tax:10090)	21838(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Limited diversity of T-cell_receptor_gamma-chain expression of murine Thy-1 + dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody .
2885757	0	T-cell_receptor_gamma-chain	14,41	Thy-1	67,72	T-cell receptor gamma-chain	Thy-1	110067(Tax:10090)	21838(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of T-cell_receptor_gamma-chain RNA expression in murine Thy-1 + dendritic epidermal cells .
11719440	0	T-cell_receptor_gamma_chain_alternate_reading_frame_protein	0,59	TARP	61,65	T-cell receptor gamma chain alternate reading frame protein	TARP	445347	445347	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	T-cell_receptor_gamma_chain_alternate_reading_frame_protein -LRB- TARP -RRB- expression in prostate_cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin .
3091711	0	T-cell_replacing_factor	0,23	interleukin-2	56,69	T-cell replacing factor	interleukin-2	3567	3558	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	T-cell_replacing_factor activity of recombinant-derived interleukin-2 requires gamma-interferon .
17342733	0	T-complex_testis_expressed_5	22,50	Tctex5	52,58	T-complex testis expressed 5	Tctex5	76497(Tax:10090)	76497(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of a novel T-complex_testis_expressed_5 -LRB- Tctex5 -RRB- in mouse testis , epididymis , and spermatozoa .
2989022	0	T-lymphoblast-specific_nucleoside_kinase	0,40	deoxycytidine_kinase	79,99	T-lymphoblast-specific nucleoside kinase	deoxycytidine kinase	25987	1633	Gene	Gene	START_ENTITY|dep|characterization characterization|nmod|END_ENTITY	T-lymphoblast-specific_nucleoside_kinase : characterization and comparison with deoxycytidine_kinase .
8687197	0	T-lymphotropic_virus_type_I-associated_myelopathy_and_tax	6,63	CD4	83,86	T-lymphotropic virus type I-associated myelopathy and tax	CD4	6900	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|T T|compound|END_ENTITY	Human T-lymphotropic_virus_type_I-associated_myelopathy_and_tax gene expression in CD4 + T lymphocytes .
24616093	0	T-synthase	59,69	Cosmc	98,103	T-synthase	Cosmc	56913	29071	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel protein binding motif within the T-synthase for the molecular chaperone Cosmc .
7711079	0	T/EBP	89,94	thyroid-specific_enhancer-binding_protein	46,87	T/EBP	thyroid-specific enhancer-binding protein	21869(Tax:10090)	21869(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The complete nucleotide sequence of the mouse thyroid-specific_enhancer-binding_protein -LRB- T/EBP -RRB- gene : extensive identity of the deduced amino_acid sequence with the human protein .
18554583	0	T0156	50,55	phosphodiesterase_type_5	69,93	T0156	phosphodiesterase type 5	1067740(Tax:209261)	171115(Tax:10116)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	Prevention of nitroglycerin tolerance in vitro by T0156 , a selective phosphodiesterase_type_5 inhibitor .
2455894	0	T11	25,28	CD2	30,33	T11	CD2	914	914	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Adhesion domain of human T11 -LRB- CD2 -RRB- is encoded by a single exon .
2894031	0	T11	69,72	CD2	74,77	T11	CD2	110621(Tax:10090)	12481(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Exon-intron organization and sequence comparison of human and murine T11 -LRB- CD2 -RRB- genes .
2896210	0	T11	13,16	CD2	18,21	T11	CD2	914	914	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for T11 -LRB- CD2 -RRB- maps to chromosome 1 in humans and to chromosome 3 in mice .
6507005	0	T3	15,17	rT3	19,22	T3	rT3	24754(Tax:10116)	24754(Tax:10116)	Gene	Gene	T4|appos|START_ENTITY T4|appos|END_ENTITY	Serum free T4 , T3 , rT3 , 3,3 ' - diiodothyronine and 3 ' ,5 ' - diiodothyronine measured by ultrafiltration .
17038507	0	TAAR1	142,147	trace_amine-associated_receptor1	51,83	TAAR1	trace amine-associated receptor1	113914(Tax:10116)	134864	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Pharmacologic characterization of the cloned human trace_amine-associated_receptor1 -LRB- TAAR1 -RRB- and evidence for species differences with the rat TAAR1 .
18524885	0	TAAR1	96,101	trace_amine-associated_receptor_1	61,94	TAAR1	trace amine-associated receptor 1	134864	134864	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Pharmacological characterization of membrane-expressed human trace_amine-associated_receptor_1 -LRB- TAAR1 -RRB- by a bioluminescence resonance energy transfer cAMP biosensor .
26302754	0	TAAR1	59,64	trace_amine-associated_receptor_1	24,57	TAAR1	trace amine-associated receptor 1	134864	134864	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Methamphetamine induces trace_amine-associated_receptor_1 -LRB- TAAR1 -RRB- expression in human T lymphocytes : role in immunomodulation .
17097106	0	TAAR6	54,59	trace_amine_associated_receptor_6	19,52	TAAR6	trace amine associated receptor 6	319100	319100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the trace_amine_associated_receptor_6 -LRB- TAAR6 -RRB- gene with schizophrenia and bipolar_disorder in a Korean case control sample .
16311020	0	TAB2	11,15	JNK	57,60	TAB2	JNK	37216(Tax:7227)	44801(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Drosophila TAB2 is required for the immune activation of JNK and NF-kappaB .
17521418	0	TAC1	22,26	Hcrtr-2	46,53	TAC1	Hcrtr-2	475239(Tax:9615)	399545(Tax:9615)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of TAC1 , PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain .
23759142	0	TAC1	100,104	MeCP2	110,115	TAC1	MeCP2	6863	4204	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Comparative DNA methylation among females with neurodevelopmental_disorders and seizures identifies TAC1 as a MeCP2 target gene .
20660792	0	TAC4	44,48	tachykinin_4	25,37	TAC4	tachykinin 4	93670(Tax:10090)	93670(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Targeted deletion of the tachykinin_4 gene -LRB- TAC4 - / - -RRB- influences the early stages of B lymphocyte development .
11903063	0	TACC1	54,59	transforming_acidic_coiled-coil_1	19,52	TACC1	transforming acidic coiled-coil 1	6867	6867	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Interaction of the transforming_acidic_coiled-coil_1 -LRB- TACC1 -RRB- protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells .
20566684	0	TACC3	30,35	Clathrin_heavy_chain	0,20	TACC3	Clathrin heavy chain	10460	1213	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Clathrin_heavy_chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability .
22842144	0	TACC3	21,26	DOCK7	0,5	TACC3	DOCK7	21335(Tax:10090)	67299(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis .
11360299	0	TACE	54,58	ADAM_17	45,52	TACE	ADAM 17	6868	6868	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Astrocyte and endothelial cell expression of ADAM_17 -LRB- TACE -RRB- in adult human CNS .
12606576	0	TACE	0,4	EGFR	43,47	TACE	EGFR	11491(Tax:10090)	13645(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	TACE is required for the activation of the EGFR by TGF-alpha in tumors .
18021299	0	TACE	32,36	Interleukin-1_beta	0,18	TACE	Interleukin-1 beta	6868	3553	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Interleukin-1_beta up-regulates TACE to enhance alpha-cleavage of APP in neurons : resulting decrease in Abeta production .
1971562	0	TACE	80,84	P-450c	8,14	TACE	P-450c	57027(Tax:10116)	24296(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of P-450c in the formation of a reactive intermediate of chlorotrianisene -LRB- TACE -RRB- by hepatic microsomes from methylcholanthrene-treated rats .
19201862	0	TACE	28,32	Sox9	38,42	TACE	Sox9	11491(Tax:10090)	20682(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF .
25371038	0	TACE	87,91	Src	69,72	TACE	Src	57027(Tax:10116)	83805(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	TNFa shedding in Mechanically Stressed Cardiomyocytes is mediated by Src Activation of TACE .
12606576	0	TACE	0,4	TGF-alpha	51,60	TACE	TGF-alpha	11491(Tax:10090)	21802(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	TACE is required for the activation of the EGFR by TGF-alpha in tumors .
26842246	0	TACE	135,139	TNF-Alpha	60,69	TACE	TNF-Alpha	11491(Tax:10090)	21926(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|dep|Inhibition	Alcohol Decreases Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric_Oxide and Protein_Kinase-Mediated Inhibition of TACE .
21078557	0	TACE	71,75	TNF-a_converting_enzyme	46,69	TACE	TNF-a converting enzyme	57027(Tax:10116)	57027(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure based optimization of chromen-based TNF-a_converting_enzyme -LRB- TACE -RRB- inhibitors on S1 ' pocket and their quantitative structure-activity relationship -LRB- QSAR -RRB- study .
17264149	0	TACE	0,4	TNF-alpha	16,25	TACE	TNF-alpha	11491(Tax:10090)	21926(Tax:10090)	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	TACE release of TNF-alpha mediates mechanotransduction-induced activation of p38_MAPK and myogenesis .
16459338	0	TACE	69,73	TNF-alpha_converting_enzyme	40,67	TACE	TNF-alpha converting enzyme	6868	6868	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Stabilization of the autoproteolysis of TNF-alpha_converting_enzyme -LRB- TACE -RRB- results in a novel crystal form suitable for structure-based drug design studies .
16511637	0	TACE	29,33	TNF-alpha_converting_enzyme	0,27	TACE	TNF-alpha converting enzyme	6868	6868	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	TNF-alpha_converting_enzyme -LRB- TACE -RRB- protein expression in different clinical subtypes of multiple_sclerosis .
17936631	0	TACE	43,47	TNF-alpha_converting_enzyme	14,41	TACE	TNF-alpha converting enzyme	6868	6868	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Chromen-based TNF-alpha_converting_enzyme -LRB- TACE -RRB- inhibitors : design , synthesis , and biological evaluation .
19729328	0	TACE	63,67	TNF-alpha_converting_enzyme	34,61	TACE	TNF-alpha converting enzyme	6868	6868	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Prediction of novel and selective TNF-alpha_converting_enzyme -LRB- TACE -RRB- inhibitors and characterization of correlative molecular descriptors by machine learning approaches .
20022498	0	TACE	67,71	TNF-alpha_converting_enzyme	38,65	TACE	TNF-alpha converting enzyme	6868	6868	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	The discovery of novel tartrate-based TNF-alpha_converting_enzyme -LRB- TACE -RRB- inhibitors .
18296613	0	TACE	47,51	Tumor_necrosis_factor-alpha-converting_enzyme	0,45	TACE	Tumor necrosis factor-alpha-converting enzyme	6868	6868	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Tumor_necrosis_factor-alpha-converting_enzyme -LRB- TACE -RRB- levels in periodontal_diseases .
24955855	0	TACE	38,42	colony-stimulating_factor_1_receptor	81,117	TACE	colony-stimulating factor 1 receptor	6868	1436	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and mutagenesis of the TACE and y-secretase cleavage sites in the colony-stimulating_factor_1_receptor .
22246777	0	TACE	89,93	iRhom2	41,47	TACE	iRhom2	11491(Tax:10090)	217344(Tax:10090)	Gene	Gene	trafficking|nmod|START_ENTITY promote|dobj|trafficking END_ENTITY|xcomp|promote	Tumor_necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE .
22246778	0	TACE	21,25	iRhom2	0,6	TACE	iRhom2	11491(Tax:10090)	217344(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS .
16737974	0	TACE	125,129	tumor_necrosis_factor-alpha-converting_enzyme	78,123	TACE	tumor necrosis factor-alpha-converting enzyme	6868	6868	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	5-HT2A_receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor_necrosis_factor-alpha-converting_enzyme -LRB- TACE -RRB- activation and heparin-bound epidermal growth factor-like growth factor -LRB- HB-EGF -RRB- shedding in mesangial cells .
17822026	0	TACE	144,148	tumor_necrosis_factor-alpha_converting_enzyme	97,142	TACE	tumor necrosis factor-alpha converting enzyme	6868	6868	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Inhibition of proliferation , adhesion and invasion ability of human lung_carcinoma cell A549 by tumor_necrosis_factor-alpha_converting_enzyme -LRB- TACE -RRB- -RSB- .
10956646	0	TACI	56,60	APRIL	112,117	TACI	APRIL	23495	8741	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Tumor necrosis factor -LRB- TNF -RRB- receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS .
17119122	0	TACI	0,4	APRIL	33,38	TACI	APRIL	23495	8741	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TACI regulates IgA production by APRIL in collaboration with HSPG .
22699762	0	TACI	73,77	APRIL	109,114	TACI	APRIL	23495	8741	Gene	Gene	TNFRSF13B|appos|START_ENTITY classifications|appos|TNFRSF13B classifications|appos|TNFSF13 TNFSF13|appos|END_ENTITY	Three different classifications , B lymphocyte subpopulations , TNFRSF13B -LRB- TACI -RRB- , TNFRSF13C -LRB- BAFF-R -RRB- , TNFSF13 -LRB- APRIL -RRB- gene mutations , CTLA-4 and ICOS gene polymorphisms in Turkish patients with common_variable_immunodeficiency .
23202984	0	TACI	50,54	APRIL	41,46	TACI	APRIL	23495	8741	Gene	Gene	analysis|nmod|START_ENTITY analysis|nmod|inhibition inhibition|nmod|END_ENTITY	Structural analysis of the inhibition of APRIL by TACI and BCMA through molecular dynamics simulations .
17942754	0	TACI	0,4	BAFF	55,59	TACI	BAFF	23495	10673	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	TACI , unlike BAFF-R , is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts .
23620746	0	TACI	25,29	BAFF	72,76	TACI	BAFF	57916(Tax:10090)	24099(Tax:10090)	Gene	Gene	evidence|dep|START_ENTITY induces|nsubj|evidence induces|xcomp|signalling signalling|nmod|END_ENTITY	No evidence that soluble TACI induces signalling via membrane-expressed BAFF and APRIL in myeloid cells .
23954794	0	TACI	49,53	BAFF	31,35	TACI	BAFF	23495	10673	Gene	Gene	amino_acid|nmod|START_ENTITY amino_acid|nmod|binding binding|compound|END_ENTITY	Identify the key amino_acid of BAFF binding with TACI .
17154264	0	TACI	0,4	BAFF-R	52,58	TACI	BAFF-R	23495	115650	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|production production|acl|costimulated costimulated|nmod|END_ENTITY	TACI attenuates antibody production costimulated by BAFF-R and CD40 .
17942754	0	TACI	0,4	BAFF-R	13,19	TACI	BAFF-R	23495	115650	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	TACI , unlike BAFF-R , is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts .
22699762	0	TACI	73,77	BAFF-R	91,97	TACI	BAFF-R	23495	115650	Gene	Gene	TNFRSF13B|appos|START_ENTITY TNFRSF13B|appos|TNFRSF13C TNFRSF13C|appos|END_ENTITY	Three different classifications , B lymphocyte subpopulations , TNFRSF13B -LRB- TACI -RRB- , TNFRSF13C -LRB- BAFF-R -RRB- , TNFSF13 -LRB- APRIL -RRB- gene mutations , CTLA-4 and ICOS gene polymorphisms in Turkish patients with common_variable_immunodeficiency .
12594954	0	TACI	77,81	BLyS	99,103	TACI	BLyS	57916(Tax:10090)	24099(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Loss of TACI causes fatal lymphoproliferation and autoimmunity , establishing TACI as an inhibitory BLyS receptor .
12594954	0	TACI	8,12	BLyS	99,103	TACI	BLyS	57916(Tax:10090)	24099(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY causes|nsubj|Loss causes|advcl|establishing establishing|dobj|TACI TACI|nmod|receptor receptor|compound|END_ENTITY	Loss of TACI causes fatal lymphoproliferation and autoimmunity , establishing TACI as an inhibitory BLyS receptor .
25162001	0	TACI	14,18	BLyS	22,26	TACI	BLyS	23495	10673	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Serum soluble TACI , a BLyS receptor , is a powerful prognostic marker of outcome in chronic_lymphocytic_leukemia .
26139429	0	TACI	18,22	IL-10	32,37	TACI	IL-10	23495	3586	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|compound|END_ENTITY	The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells .
10880535	0	TACI	0,4	TALL-1	40,46	TACI	TALL-1	57916(Tax:10090)	24099(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	TACI is a TRAF-interacting receptor for TALL-1 , a tumor necrosis factor family member involved in B cell regulation .
19392801	0	TACI	40,44	TNFRSF13B	29,38	TACI	TNFRSF13B	23495	23495	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Role of polymorphisms in the TNFRSF13B -LRB- TACI -RRB- gene in Spanish patients with immunoglobulin_A_deficiency .
20184394	0	TACI	0,4	TRAF2	53,58	TACI	TRAF2	23495	7186	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling .
24817687	0	TACR1	49,54	tachykinin_receptor_1	27,48	TACR1	tachykinin receptor 1	6869	6869	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Genetic association of the tachykinin_receptor_1 TACR1 gene in bipolar_disorder , attention deficit_hyperactivity_disorder , and the alcohol_dependence_syndrome .
25753752	0	TAD2	38,42	p300	75,79	TAD2	p300	134637	2033	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Characterization of the p300 Taz2-p53 TAD2 complex and comparison with the p300 Taz2-p53 TAD1 complex .
24560937	0	TADG-12	0,7	insulin	105,112	TADG-12	insulin	64699	3630	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	TADG-12 as an early marker in the development of pancreatic_ductal_adenocarcinoma -LRB- PDAC -RRB- : involvement of insulin containing cells .
10611293	0	TAF	42,45	MDM2	80,84	TAF	MDM2	129685	4193	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	The alpha-helical FXXPhiPhi motif in p53 : TAF interaction and discrimination by MDM2 .
12458202	0	TAF-5	39,44	TAFII100	52,60	TAF-5	TAFII100	6877	6877	Gene	Gene	requirement|nmod|START_ENTITY requirement|appos|END_ENTITY	A broad but restricted requirement for TAF-5 -LRB- human TAFII100 -RRB- for embryonic transcription in Caenorhabditis_elegans .
24036077	0	TAF1	59,63	CIITA	28,33	TAF1	CIITA	6872	4261	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Transcriptional coactivator CIITA , a functional homolog of TAF1 , has kinase activity .
15525647	0	TAF1	76,80	HAF2	12,16	TAF1	HAF2	821437(Tax:3702)	821437(Tax:3702)	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Arabidopsis HAF2 gene encoding TATA-binding protein -LRB- TBP -RRB- - associated factor TAF1 , is required to integrate light signals to regulate gene expression and growth .
22711989	0	TAF1	100,104	cyclin_D1	40,49	TAF1	cyclin D1	6872	595	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|END_ENTITY	Phosphorylation-dependent regulation of cyclin_D1 and cyclin_A gene transcription by TFIID subunits TAF1 and TAF7 .
10894955	0	TAF1A	40,45	SL1	166,169	TAF1A	SL1	9015	9013	Gene	Gene	localization|amod|START_ENTITY localization|nmod|END_ENTITY	Genomic localization of the human genes TAF1A , TAF1B and TAF1C , encoding TAF -LRB- I -RRB- 48 , TAF -LRB- I -RRB- 63 and TAF -LRB- I -RRB- 110 subunits of class I general transcription initiation factor SL1 .
23326574	0	TAF4	8,12	Rta	46,49	TAF4	Rta	6874	116535	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|nmod|END_ENTITY	Role of TAF4 in transcriptional activation by Rta of Epstein-Barr_Virus .
18391197	0	TAF7	16,20	TFIIH	54,59	TAF7	TFIIH	6879	2068	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb .
12529754	0	TAFI	45,49	Thrombin_activatable_fibrinolysis_inhibitor	0,43	TAFI	Thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- levels in patients with coronary_artery_disease investigated by angiography .
12645517	0	TAFI	74,78	thrombin-activable_fibrinolysis_inhibitor	31,72	TAFI	thrombin-activable fibrinolysis inhibitor	1361	1361	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Acute phase mediators modulate thrombin-activable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene expression in HepG2 cells .
11565542	0	TAFI	134,138	thrombin-activatable_fibrinolysis_inhibitor	89,132	TAFI	thrombin-activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel , possibly functional , single nucleotide polymorphism in the coding region of the thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene is also associated with TAFI levels .
17264944	0	TAFI	66,70	thrombin-activatable_fibrinolysis_inhibitor	21,64	TAFI	thrombin-activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic variation in thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- is associated with the risk of splanchnic_vein_thrombosis .
18612536	0	TAFI	149,153	thrombin-activatable_fibrinolysis_inhibitor	104,147	TAFI	thrombin-activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Absolute risk of venous and arterial thromboembolism in thrombophilic families is not increased by high thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- levels .
19967152	0	TAFI	59,63	thrombin-activatable_fibrinolysis_inhibitor	14,57	TAFI	thrombin-activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- is up-regulated by increase in intracellular cyclic_AMP levels in cultured HepG2 cells .
11341503	0	TAFI	59,63	thrombin_activatable_fibrinolysis_inhibitor	14,57	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Low levels of thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- in patients with chronic liver_disease .
12871455	0	TAFI	53,57	thrombin_activatable_fibrinolysis_inhibitor	8,51	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- in patients with acute_pulmonary_embolism .
14669439	0	TAFI	63,67	thrombin_activatable_fibrinolysis_inhibitor	18,61	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	-LSB- Concentration of thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- in cord blood and maternal blood during labor -RSB- .
14719174	0	TAFI	98,102	thrombin_activatable_fibrinolysis_inhibitor	53,96	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The impact of single nucleotide polymorphisms of the thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene on TAFI antigen levels in healthy children and pediatric oncology patients .
16803573	0	TAFI	83,87	thrombin_activatable_fibrinolysis_inhibitor	38,81	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The effect of genetic variants in the thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene on TAFI-antigen levels , clot lysis time and the risk of venous_thrombosis .
16959692	0	TAFI	63,67	thrombin_activatable_fibrinolysis_inhibitor	18,61	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Decrements in the thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- levels in association with orlistat treatment in obesity .
17090955	0	TAFI	54,58	thrombin_activatable_fibrinolysis_inhibitor	9,52	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Elevated thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- antigen levels in overt and subclinical_hypothyroid patients were reduced by levothyroxine replacement .
17579260	0	TAFI	74,78	thrombin_activatable_fibrinolysis_inhibitor	29,72	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of unactivated thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- are down-regulated in young adult women : analysis of a normal Japanese population .
23256818	0	TAFI	77,81	thrombin_activatable_fibrinolysis_inhibitor	32,75	TAFI	thrombin activatable fibrinolysis inhibitor	1361	1361	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Effect of warfarin treatment on thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- activation and TAFI-mediated inhibition of fibrinolysis .
12458202	0	TAFII100	52,60	TAF-5	39,44	TAFII100	TAF-5	6877	6877	Gene	Gene	requirement|appos|START_ENTITY requirement|nmod|END_ENTITY	A broad but restricted requirement for TAF-5 -LRB- human TAFII100 -RRB- for embryonic transcription in Caenorhabditis_elegans .
11959914	0	TAFII130	47,55	HP1	32,35	TAFII130	HP1	6874	23468	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Isoform-specific interaction of HP1 with human TAFII130 .
11126356	0	TAFII250	67,75	Cyclin_D1	0,9	TAFII250	Cyclin D1	6872	595	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Cyclin_D1 suppresses_retinoblastoma protein-mediated inhibition of TAFII250 kinase activity .
7590250	0	TAFII250	6,14	RAP74	30,35	TAFII250	RAP74	6872	2962	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human TAFII250 interacts with RAP74 : implications for RNA polymerase II initiation .
8625415	0	TAFII250	0,8	RAP74	89,94	TAFII250	RAP74	6872	2962	Gene	Gene	kinase|nsubj|START_ENTITY kinase|acl:relcl|phosphorylates phosphorylates|dobj|END_ENTITY	TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74 .
11592977	0	TAFII250	19,27	TAFII55	0,7	TAFII250	TAFII55	6872	6879	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	TAFII55 binding to TAFII250 inhibits its acetyltransferase activity .
9171108	0	TAFII32	76,83	CIITA	29,34	TAFII32	CIITA	6880	4261	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32 .
11592977	0	TAFII55	0,7	TAFII250	19,27	TAFII55	TAFII250	6879	6872	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	TAFII55 binding to TAFII250 inhibits its acetyltransferase activity .
12374219	0	TAG-1	36,41	Lyn	65,68	TAG-1	Lyn	25356(Tax:10116)	81515(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of GPI-anchored protein TAG-1 with src-family kinase Lyn in lipid rafts of cerebellar granule cells .
8586412	0	TAG-1	72,77	TAX1	10,14	TAG-1	TAX1	6900	6900	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1 / axonin-1 : genomic structure and basic promoter .
9543336	0	TAG-1	63,68	axonin-1	69,77	TAG-1	axonin-1	21367(Tax:10090)	21367(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of the axon growth-related neural adhesion molecule TAG-1 / axonin-1 in the adult mouse brain .
9615232	0	TAGLN	64,69	SM22	53,57	TAGLN	SM22	6876	6876	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression and cytogenetic localization of the human SM22 gene -LRB- TAGLN -RRB- .
24959893	0	TAGLN2	55,61	MiR-133b	0,8	TAGLN2	MiR-133b	21346(Tax:10090)	723817(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-133b regulates the expression of the Actin protein TAGLN2 during oocyte growth and maturation : a potential target for infertility therapy .
19536134	0	TAK1	0,4	BMP	34,37	TAK1	BMP	26409(Tax:10090)	649	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	TAK1 is an essential regulator of BMP signalling in cartilage .
16179944	0	TAK1	56,60	Plenty_of_SH3s	33,47	TAK1	Plenty of SH3s	39659(Tax:7227)	36990(Tax:7227)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The RING-finger scaffold protein Plenty_of_SH3s targets TAK1 to control immunity signalling in Drosophila .
12243350	0	TAK1	0,4	RANTES	41,47	TAK1	RANTES	6885	6352	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	TAK1 mediates lipopolysaccharide-induced RANTES promoter activation in BV-2 microglial cells .
21233843	0	TAK1	0,4	SCF	15,18	TAK1	SCF	6885	4254	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TAK1 regulates SCF expression to modulate PKBa activity that protects keratinocytes from ROS-induced apoptosis .
24144697	0	TAK1	0,4	SOX9	15,19	TAK1	SOX9	26409(Tax:10090)	20682(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages .
18829460	0	TAK1	62,66	TAK1-binding_protein_1	0,22	TAK1	TAK1-binding protein 1	26409(Tax:10090)	66513(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TAK1-binding_protein_1 , TAB1 , mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling .
22167179	0	TAK1	262,266	TAK1-binding_protein_2	208,230	TAK1	TAK1-binding protein 2	26409(Tax:10090)	68652(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Reciprocal inhibition between the transforming_growth_factor-b-activated_kinase_1 -LRB- TAK1 -RRB- and apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding_protein_2 -LRB- TAB2 -RRB- , an adapter protein for TAK1 .
24728340	0	TAK1	26,30	TGF-b-activated_kinase_1	0,24	TAK1	TGF-b-activated kinase 1	6885	6885	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	TGF-b-activated_kinase_1 -LRB- TAK1 -RRB- signaling regulates TGF-b-induced WNT-5A expression in airway smooth muscle cells via Sp1 and b-catenin .
21331078	0	TAK1	13,17	USP4	0,4	TAK1	USP4	6885	7375	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	USP4 targets TAK1 to downregulate TNFa-induced NF-kB activation .
10757786	0	TAK1	0,4	c-Jun_N-terminal_kinase	21,44	TAK1	c-Jun N-terminal kinase	39659(Tax:7227)	44801(Tax:7227)	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	TAK1 participates in c-Jun_N-terminal_kinase signaling during Drosophila development .
15082531	0	TAK1	74,78	c-Myb	56,61	TAK1	c-Myb	6885	4602	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1 , HIPK2 , and NLK .
24751651	0	TAK1	23,27	hnRNP_K	36,43	TAK1	hnRNP K	6885	3190	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Translation control of TAK1 mRNA by hnRNP_K modulates LPS-induced macrophage activation .
19393267	0	TAK1	42,46	p38	76,79	TAK1	p38	6885	1432	Gene	Gene	activation|compound|START_ENTITY activation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding_protein_1 .
17079228	0	TAK1	37,41	phosphatase_6	8,21	TAK1	phosphatase 6	6885	5537	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	Protein phosphatase_6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway .
16260783	0	TAK1	0,4	receptor-interacting_protein	89,117	TAK1	receptor-interacting protein	6885	8737	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	TAK1 is recruited to the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- _ receptor_1 complex in a receptor-interacting_protein -LRB- RIP -RRB- - dependent manner and cooperates with MEKK3 leading to NF-kappaB activation .
26114584	0	TAK1	111,115	transforming_growth_factor_b-activated_kinase_1	62,109	TAK1	transforming growth factor b-activated kinase 1	6885	6885	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Disruption of thioredoxin metabolism enhances the toxicity of transforming_growth_factor_b-activated_kinase_1 -LRB- TAK1 -RRB- inhibition in KRAS-mutated colon_cancer cells .
16260783	0	TAK1	0,4	tumor_necrosis_factor-alpha	25,52	TAK1	tumor necrosis factor-alpha	6885	7124	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	TAK1 is recruited to the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- _ receptor_1 complex in a receptor-interacting_protein -LRB- RIP -RRB- - dependent manner and cooperates with MEKK3 leading to NF-kappaB activation .
18829460	0	TAK1-binding_protein_1	0,22	TAK1	62,66	TAK1-binding protein 1	TAK1	66513(Tax:10090)	26409(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	TAK1-binding_protein_1 , TAB1 , mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling .
19393267	0	TAK1-binding_protein_1	99,121	p38	76,79	TAK1-binding protein 1	p38	10454	1432	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding_protein_1 .
22167179	0	TAK1-binding_protein_2	208,230	TAK1	262,266	TAK1-binding protein 2	TAK1	68652(Tax:10090)	26409(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Reciprocal inhibition between the transforming_growth_factor-b-activated_kinase_1 -LRB- TAK1 -RRB- and apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- mitogen-activated protein kinase kinase kinases and its suppression by TAK1-binding_protein_2 -LRB- TAB2 -RRB- , an adapter protein for TAK1 .
23449975	0	TAK1-binding_protein_2	86,108	miR-155	0,7	TAK1-binding protein 2	miR-155	68652(Tax:10090)	387173(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding_protein_2 .
22792348	0	TAL1	53,57	Angiopoietin-2	0,14	TAL1	Angiopoietin-2	6886	285	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Angiopoietin-2 is a direct transcriptional target of TAL1 , LYL1 and LMO2 in endothelial cells .
22982397	0	TAL1	25,29	erythropoietin_receptor	45,68	TAL1	erythropoietin receptor	6886	2057	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	T-cell_acute_leukemia_1 -LRB- TAL1 -RRB- regulation of erythropoietin_receptor and association with excessive erythrocytosis .
7744799	0	TAL1/SCL	47,55	Erythropoietin	0,14	TAL1/SCL	Erythropoietin	21349(Tax:10090)	13856(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene stimulates|dobj|transcription stimulates|nsubj|END_ENTITY	Erythropoietin stimulates transcription of the TAL1/SCL gene and phosphorylation of its protein products .
14651981	0	TAL1/SCL	48,56	p16INK4A	88,96	TAL1/SCL	p16INK4A	21349(Tax:10090)	12578(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	The basic helix-loop-helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTalpha genes .
9339383	0	TALDO1	30,36	transaldolase	10,23	TALDO1	transaldolase	6888	6888	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human transaldolase gene -LRB- TALDO1 -RRB- is located on chromosome 11 at p15.4-p15 .5 .
10908663	0	TALL-1	84,90	B_cell_maturation_protein	0,25	TALL-1	B cell maturation protein	10673	608	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	B_cell_maturation_protein is a receptor for the tumor necrosis factor family member TALL-1 .
10880535	0	TALL-1	40,46	TACI	0,4	TALL-1	TACI	24099(Tax:10090)	57916(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	TACI is a TRAF-interacting receptor for TALL-1 , a tumor necrosis factor family member involved in B cell regulation .
16547966	0	TANK	70,74	TFG	4,7	TANK	TFG	10010	10342	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The TFG protein , involved in oncogenic rearrangements , interacts with TANK and NEMO , two proteins involved in the NF-kappaB pathway .
22945920	0	TANK-binding_kinase_1	133,154	IFN-b	53,58	TANK-binding kinase 1	IFN-b	29110	3456	Gene	Gene	degradation|nmod|START_ENTITY promoting|dobj|degradation regulates|advcl|promoting regulates|dobj|production production|amod|END_ENTITY	TRAF-interacting_protein -LRB- TRIP -RRB- negatively regulates IFN-b production and antiviral response by promoting proteasomal degradation of TANK-binding_kinase_1 .
24043902	0	TANK-binding_kinase_1	77,98	IFN-b	19,24	TANK-binding kinase 1	IFN-b	56480(Tax:10090)	15977(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY inhibition|nmod|activity production|nmod|inhibition production|amod|END_ENTITY	Lithium attenuates IFN-b production and antiviral response via inhibition of TANK-binding_kinase_1 kinase activity .
24048896	0	TANK-binding_kinase_1	79,100	IFN-b	34,39	TANK-binding kinase 1	IFN-b	56480(Tax:10090)	15977(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY regulates|nmod|interaction regulates|dobj|production production|amod|END_ENTITY	Annexin-A1 regulates TLR-mediated IFN-b production through an interaction with TANK-binding_kinase_1 .
25070846	0	TANK-binding_kinase_1	105,126	IFN-b	52,57	TANK-binding kinase 1	IFN-b	29110	3456	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Ubiquitin-specific protease 2b negatively regulates IFN-b production and antiviral activity by targeting TANK-binding_kinase_1 .
23028469	0	TANK-binding_kinase_1	25,46	NEMO	0,4	TANK-binding kinase 1	NEMO	29110	8517	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	NEMO binds ubiquitinated TANK-binding_kinase_1 -LRB- TBK1 -RRB- to regulate innate immune responses to RNA viruses .
22203995	0	TANK-binding_kinase_1	0,21	serpinB2	66,74	TANK-binding kinase 1	serpinB2	56480(Tax:10090)	18788(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	TANK-binding_kinase_1 -LRB- TBK1 -RRB- controls cell survival through PAI-2 / serpinB2 and transglutaminase_2 .
25456499	0	TAO1/2	27,33	Myosin_Va	44,53	TAO1/2	Myosin Va	57551;9344	4644	Gene	Gene	START_ENTITY|nmod|Function Function|compound|END_ENTITY	MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin_Va Function in Promoting Spine Synapse Development .
11157746	0	TAP	67,70	US6	39,42	TAP	US6	6890	3077555(Tax:10359)	Gene	Gene	binding|nmod|START_ENTITY inhibits|xcomp|binding inhibits|nsubj|END_ENTITY	The human_cytomegalovirus gene product US6 inhibits ATP binding by TAP .
9562372	0	TAP	119,122	transporter_associated_with_antigen_presentation	69,117	TAP	transporter associated with antigen presentation	8615	8615	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Peptide transport in human lymphoblastoid and tumor cells : effect of transporter_associated_with_antigen_presentation -LRB- TAP -RRB- polymorphism .
14558951	0	TAP	63,66	transporter_associated_with_antigen_processing	15,61	TAP	transporter associated with antigen processing	6890	6890	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of transporter_associated_with_antigen_processing -LRB- TAP -RRB- in childhood acute_leukemia and its clinical significance -RSB- .
14579270	0	TAP	101,104	transporter_associated_with_antigen_processing	53,99	TAP	transporter associated with antigen processing	100329838(Tax:8355)	100329838(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two highly divergent ancient allelic lineages of the transporter_associated_with_antigen_processing -LRB- TAP -RRB- gene in Xenopus : further evidence for co-evolution among MHC class I region genes .
16690408	0	TAP	90,93	transporter_associated_with_antigen_processing	42,88	TAP	transporter associated with antigen processing	6890	6890	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Pemphigus_vulgaris is associated with the transporter_associated_with_antigen_processing -LRB- TAP -RRB- system .
24196954	0	TAP	89,92	transporter_associated_with_antigen_processing	41,87	TAP	transporter associated with antigen processing	6890	6890	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Analyses of conformational states of the transporter_associated_with_antigen_processing -LRB- TAP -RRB- protein in a native cellular membrane environment .
8267790	0	TAP	76,79	transporter_associated_with_antigen_processing	28,74	TAP	transporter associated with antigen processing	6890	6890	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Haplotypic variation of the transporter_associated_with_antigen_processing -LRB- TAP -RRB- genes and their extension of HLA class II region haplotypes .
10618282	0	TAP-1	117,122	TAP-1	22,27	TAP-1	TAP-1	6890	6890	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|nmod|END_ENTITY	Altered expression of TAP-1 and major histocompatibility complex class I in laryngeal_papillomatosis : correlation of TAP-1 with disease .
10618282	0	TAP-1	22,27	TAP-1	117,122	TAP-1	TAP-1	6890	6890	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Altered expression of TAP-1 and major histocompatibility complex class I in laryngeal_papillomatosis : correlation of TAP-1 with disease .
12213826	0	TAP1	115,119	TAP2	122,126	TAP1	TAP2	6890	6891	Gene	Gene	Complexes|compound|START_ENTITY Complexes|compound|END_ENTITY	Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes .
16624807	0	TAP1	93,97	TAP2	121,125	TAP1	TAP2	6890	6891	Gene	Gene	assembly|nmod|START_ENTITY requires|dobj|assembly requires|nmod|END_ENTITY	Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2 .
10618714	0	TAP1	12,16	p53	0,3	TAP1	p53	6890	7157	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	p53 induces TAP1 and enhances the transport of MHC class I peptides .
12213826	0	TAP2	122,126	TAP1	115,119	TAP2	TAP1	6891	6890	Gene	Gene	Complexes|compound|START_ENTITY Complexes|compound|END_ENTITY	Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes .
16624807	0	TAP2	121,125	TAP1	93,97	TAP2	TAP1	6891	6890	Gene	Gene	requires|nmod|START_ENTITY requires|dobj|assembly assembly|nmod|END_ENTITY	Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2 .
7737270	0	TAP2	96,100	thymus-leukemia_antigen	54,77	TAP2	thymus-leukemia antigen	21355(Tax:10090)	15043(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|expression expression|nmod|END_ENTITY	Surface expression of beta_2-microglobulin-associated thymus-leukemia_antigen is independent of TAP2 .
10220507	0	TAP2	65,69	transporter_associated_with_antigen_processing	15,61	TAP2	transporter associated with antigen processing	6891	6890	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Involvement of transporter_associated_with_antigen_processing 2 -LRB- TAP2 -RRB- gene polymorphisms in hepatitis_C_virus infection .
18071882	0	TAP2	66,70	transporter_associated_with_antigen_processing_2	16,64	TAP2	transporter associated with antigen processing 2	6891	6891	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Significance of transporter_associated_with_antigen_processing_2 -LRB- TAP2 -RRB- gene polymorphisms in susceptibility to dengue_viral_infection .
12882447	0	TAP26	66,71	BR22	0,4	TAP26	BR22	29080	29080	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|appos|protein	BR22 , a 26 kDa thyroid_transcription_factor-1 associated protein -LRB- TAP26 -RRB- , is expressed in human lung cells .
12882447	0	TAP26	66,71	thyroid_transcription_factor-1	15,45	TAP26	thyroid transcription factor-1	29080	7080	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	BR22 , a 26 kDa thyroid_transcription_factor-1 associated protein -LRB- TAP26 -RRB- , is expressed in human lung cells .
2398277	0	TAPA-1	0,6	Leu-13_antigen	96,110	TAPA-1	Leu-13 antigen	975	8519	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	TAPA-1 , the target of an antiproliferative antibody , is associated on the cell surface with the Leu-13_antigen .
21711701	0	TAR-RNA_binding_protein	21,44	TRBP	46,50	TAR-RNA binding protein	TRBP	6895	6895	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A proteomic study of TAR-RNA_binding_protein -LRB- TRBP -RRB- - associated factors .
15194146	0	TARC	70,74	IP-10	38,43	TARC	IP-10	6361	3627	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants , TARC and MDC , are elevated in patients with systemic_sclerosis .
17134490	0	TARC	122,126	Interleukin-4	0,13	TARC	Interleukin-4	20295(Tax:10090)	16189(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY sites|nmod|promoter mediated|nmod|sites mediated|nsubjpass|induction induction|amod|END_ENTITY	Interleukin-4 induction of the CC chemokine TARC -LRB- CCL17 -RRB- in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter .
17134490	0	TARC	44,48	Interleukin-4	0,13	TARC	Interleukin-4	20295(Tax:10090)	16189(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Interleukin-4 induction of the CC chemokine TARC -LRB- CCL17 -RRB- in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter .
11323220	0	TARC	51,55	TNF-alpha	33,42	TARC	TNF-alpha	6361	7124	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells : a possible mechanism in the inflammatory reaction of atopic_dermatitis .
12441140	0	TARC	31,35	TNF-alpha	152,161	TARC	TNF-alpha	6361	7124	Gene	Gene	CXCL10|nsubj|START_ENTITY CXCL10|nmod|END_ENTITY	IL-4 , but not IL-13 , modulates TARC -LRB- thymus_and_activation-regulated_chemokine -RRB- / CCL17 and IP-10 -LRB- interferon-induced_protein_of_10kDA -RRB- / CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line .
20185925	0	TARC	73,77	TNF-alpha	37,46	TARC	TNF-alpha	6361	7124	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|cytokines cytokines|amod|END_ENTITY	Combined stimulation with Poly -LRB- I : C -RRB- , TNF-alpha and Th2 cytokines induces TARC production by human fibroblasts from the nose , bronchioles and lungs .
11642275	0	TARC	71,75	thymus_and_activation-regulated_chemokine	28,69	TARC	thymus and activation-regulated chemokine	403586(Tax:9615)	403586(Tax:9615)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of canine thymus_and_activation-regulated_chemokine -LRB- TARC -RRB- gene and its expression in various tissues .
12390321	0	TARC	62,66	thymus_and_activation-regulated_chemokine	19,60	TARC	thymus and activation-regulated chemokine	6361	6361	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of thymus_and_activation-regulated_chemokine -LRB- TARC -RRB- in pleural_effusion samples from patients infested with Paragonimus_westermani .
25219597	0	TARC	57,61	thymus_and_activation-regulated_chemokine	14,55	TARC	thymus and activation-regulated chemokine	6361	6361	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of thymus_and_activation-regulated_chemokine -LRB- TARC -RRB- by human dermal cells , but not epidermal keratinocytes .
23354328	0	TARP	21,25	Erbin	0,5	TARP	Erbin	94242(Tax:10090)	59079(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Erbin interacts with TARP y-2 for surface expression of AMPA receptors in cortical interneurons .
11719440	0	TARP	61,65	T-cell_receptor_gamma_chain_alternate_reading_frame_protein	0,59	TARP	T-cell receptor gamma chain alternate reading frame protein	445347	445347	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	T-cell_receptor_gamma_chain_alternate_reading_frame_protein -LRB- TARP -RRB- expression in prostate_cancer cells leads to an increased growth rate and induction of caveolins and amphiregulin .
21620381	0	TAR_DNA-binding_protein-43	66,92	HO-1	109,113	TAR DNA-binding protein-43	HO-1	23435	3162	Gene	Gene	START_ENTITY|nmod|increase increase|nmod|END_ENTITY	MG132 enhances neurite outgrowth in neurons overexpressing mutant TAR_DNA-binding_protein-43 via increase of HO-1 .
25127017	0	TAR_DNA_binding_protein_43	58,84	TDP-43	86,92	TAR DNA binding protein 43	TDP-43	23435	23435	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	HIV-1 replication in human immune cells is independent of TAR_DNA_binding_protein_43 -LRB- TDP-43 -RRB- expression .
11749039	0	TASK-1	31,37	TASK-5	94,100	TASK-1	TASK-5	3777	60598	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern in brain of TASK-1 , TASK-3 , and a tandem pore domain K -LRB- + -RRB- channel subunit , TASK-5 , associated with the central auditory nervous system .
15178438	0	TASK-3	22,28	KCNK9	30,35	TASK-3	KCNK9	84429(Tax:10116)	84429(Tax:10116)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of TASK-3 -LRB- KCNK9 -RRB- to a subset of cortical neurons in the rat CNS .
23564779	0	TASK-3	85,91	KCNK9	78,83	TASK-3	KCNK9	51305	51305	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Expression and prognostic significance of the oncogenic K2P potassium channel KCNK9 -LRB- TASK-3 -RRB- in ovarian_carcinoma .
11749039	0	TASK-5	94,100	TASK-1	31,37	TASK-5	TASK-1	60598	3777	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern in brain of TASK-1 , TASK-3 , and a tandem pore domain K -LRB- + -RRB- channel subunit , TASK-5 , associated with the central auditory nervous system .
21188077	0	TAT	79,82	L-Tyrosine_Aminotransferase	50,77	TAT	L-Tyrosine Aminotransferase	817022(Tax:3702)	817022(Tax:3702)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Identification and Partial Characterization of an L-Tyrosine_Aminotransferase -LRB- TAT -RRB- from Arabidopsis_thaliana .
7739564	0	TATA-binding_protein	20,40	GAL4	0,4	TATA-binding protein	GAL4	856891(Tax:4932)	855828(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GAL4 interacts with TATA-binding_protein and coactivators .
12423206	0	TATA-binding_protein	4,24	Gal4p	86,91	TATA-binding protein	Gal4p	856891(Tax:4932)	855828(Tax:4932)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The TATA-binding_protein is not an essential target of the transcriptional activators Gal4p and Gcn4p in Saccharomyces_cerevisiae .
8006019	0	TATA-binding_protein	112,132	HMG1	32,36	TATA-binding protein	HMG1	6908	10354	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding_protein .
12571241	0	TATA-binding_protein	48,68	Mot1	0,4	TATA-binding protein	Mot1	856891(Tax:4932)	856023(Tax:4932)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Mot1 regulates the DNA binding activity of free TATA-binding_protein in an ATP-dependent manner .
18195009	0	TATA-binding_protein	79,99	Rap1p	48,53	TATA-binding protein	Rap1p	6908	54386	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The transcriptional repressor activator protein Rap1p is a direct regulator of TATA-binding_protein .
8502484	0	TATA-binding_protein	54,74	TBP	76,79	TATA-binding protein	TBP	6908	6908	Gene	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	p300 , and p300-associated proteins , are components of TATA-binding_protein -LRB- TBP -RRB- complexes .
8568841	0	TATA-binding_protein	52,72	TBP	74,77	TATA-binding protein	TBP	6908	6908	Gene	Gene	interactions|amod|START_ENTITY interactions|appos|END_ENTITY	Patch clamp and atomic force microscopy demonstrate TATA-binding_protein -LRB- TBP -RRB- interactions with the nuclear_pore_complex .
8769130	0	TATA-binding_protein	32,52	TBP	54,57	TATA-binding protein	TBP	21374(Tax:10090)	21374(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Promoter structure of the mouse TATA-binding_protein -LRB- TBP -RRB- gene .
17641088	0	TATA-binding_protein	12,32	TBP2	36,40	TATA-binding protein	TBP2	21374(Tax:10090)	56338(Tax:10090)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of TATA-binding_protein 2 -LRB- TBP2 -RRB- and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development .
21106530	0	TATA-binding_protein	90,110	c-Jun	67,72	TATA-binding protein	c-Jun	6908	3725	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding_protein -LRB- TBP -RRB- and Brf1 expression .
8754830	0	TATA-binding_protein	40,60	p53	31,34	TATA-binding protein	p53	37476(Tax:7227)	2768677(Tax:7227)	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction between p53 , the TATA-binding_protein -LRB- TBP -RRB- , andTBP-associated factors in vivo .
14967767	0	TATA-binding_protein	76,96	spinocerebellar_ataxia_type_17	105,135	TATA-binding protein	spinocerebellar ataxia type 17	6908	6314	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Possible reduced penetrance of expansion of 44 to 47 CAG/CAA repeats in the TATA-binding_protein gene in spinocerebellar_ataxia_type_17 .
10359315	0	TATA-box-binding_protein	24,48	Pax-6	0,5	TATA-box-binding protein	Pax-6	6908	5080	Gene	Gene	protein|compound|START_ENTITY interactions|nmod|protein interactions|amod|END_ENTITY	Pax-6 interactions with TATA-box-binding_protein and retinoblastoma protein .
11259579	0	TATA_binding_protein	8,28	TBP	30,33	TATA binding protein	TBP	856891(Tax:4932)	856891(Tax:4932)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of TATA_binding_protein -LRB- TBP -RRB- in yeast ribosomal dna transcription by RNA polymerase I : defects in the dual functions of transcription factor UAF can not be suppressed by TBP .
8755740	0	TATA_binding_protein	68,88	c-Myc	30,35	TATA binding protein	c-Myc	6908	4609	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Functional interaction of the c-Myc transactivation domain with the TATA_binding_protein : evidence for an induced fit model of transactivation domain folding .
18549481	0	TATA_binding_protein_associated_factor_3	0,40	p53	63,66	TATA binding protein associated factor 3	p53	83860	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TATA_binding_protein_associated_factor_3 -LRB- TAF3 -RRB- interacts with p53 and inhibits its function .
10672937	0	TATA_box-binding_protein	77,101	TBP	72,75	TATA box-binding protein	TBP	37476(Tax:7227)	37476(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	An element with palindromic structure is required for the expression of TBP -LRB- TATA_box-binding_protein -RRB- gene in Drosophila_melanogaster .
19581089	0	TATA_box-binding_protein	25,49	TBP	51,54	TATA box-binding protein	TBP	6908	6908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the TATA_box-binding_protein -LRB- TBP -RRB- gene in Chinese Han patients with spinocerebellar_ataxia .
7873754	0	TATA_box-binding_protein	28,52	TBP	54,57	TATA box-binding protein	TBP	6908	6908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Direct mapping of the human TATA_box-binding_protein -LRB- TBP -RRB- gene to 6q27 by fluorescence in situ hybridization .
25667483	0	TATI	38,42	Claudin-5	0,9	TATI	Claudin-5	6690	7122	Gene	Gene	Associated|nmod|START_ENTITY Associated|nsubj|END_ENTITY	Claudin-5 Is Associated with Elevated TATI and CA125 Levels in Mucinous Ovarian Borderline Tumors .
15963628	0	TATI	54,58	tumor-associated_trypsin_inhibitor	18,52	TATI	tumor-associated trypsin inhibitor	6690	6690	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Urinary levels of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- in the detection of transitional cell carcinoma_of_the_urinary_bladder .
1780683	0	TATI	50,54	tumor-associated_trypsin_inhibitor	14,48	TATI	tumor-associated trypsin inhibitor	6690	6690	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- in women with benign and malignant_gynecological_disease .
2717042	0	TATI	54,58	tumor-associated_trypsin_inhibitor	18,52	TATI	tumor-associated trypsin inhibitor	6690	6690	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- in subjects with gastrointestinal_diseases .
17267202	0	TATI	55,59	tumour-associated_trypsin_inhibitor	18,53	TATI	tumour-associated trypsin inhibitor	6690	6690	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of tumour-associated_trypsin_inhibitor -LRB- TATI -RRB- enhances tumour growth and is associated with portal vein invasion , early recurrence and a stage-independent prognostic factor of hepatocellular_carcinoma .
8774855	0	TAUT	53,57	taurine_transporter	32,51	TAUT	taurine transporter	21366(Tax:10090)	21366(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the mouse retinal taurine_transporter -LRB- TAUT -RRB- by protein kinases in Xenopus oocytes .
8586412	0	TAX1	10,14	TAG-1	72,77	TAX1	TAG-1	6900	6900	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1 / axonin-1 : genomic structure and basic promoter .
16767081	0	TAX1BP2	75,82	Tax	27,30	TAX1BP2	Tax	55697	6900	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication .
9826564	0	TAXREB107	65,74	FGF-2	29,34	TAXREB107	FGF-2	6128	2247	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Intracellular association of FGF-2 with the ribosomal_protein_L6 / TAXREB107 .
25587023	0	TAZ	36,39	Hypoxia-inducible_factor_1	0,26	TAZ	Hypoxia-inducible factor 1	6901	3091	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Hypoxia-inducible_factor_1 mediates TAZ expression and nuclear localization to induce the breast_cancer stem cell phenotype .
26116754	0	TAZ	14,17	PARD3	0,5	TAZ	PARD3	6901	56288	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction .
22575641	0	TAZ	60,63	Runx2	73,78	TAZ	Runx2	6901	860	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Phorbaketal_A stimulates osteoblast differentiation through TAZ mediated Runx2 activation .
17927494	0	TAZ	48,51	tumor_necrosis_factor-alpha	9,36	TAZ	tumor necrosis factor-alpha	6901	7124	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Elevated tumor_necrosis_factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1 + mesenchymal stem cells in patients with multiple_myeloma .
15641773	0	TAZ1	9,13	CBP/p300	0,8	TAZ1	CBP/p300	10472	1387;2033	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	CBP/p300 TAZ1 domain forms a structured scaffold for ligand binding .
14594809	0	TAZ1	19,23	CREB-binding_protein	38,58	TAZ1	CREB-binding protein	6901	1387	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Interaction of the TAZ1 domain of the CREB-binding_protein with the activation domain of CITED2 : regulation by competition between intrinsically unstructured ligands for non-identical binding sites .
19139399	0	TAp73	0,5	BubR1	62,67	TAp73	BubR1	22062(Tax:10090)	12236(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY	TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity .
17693405	0	TAp73	0,5	p53	32,35	TAp73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	TAp73 is a downstream target of p53 in controlling the cellular defense against stress .
11241784	0	TB-RBP	117,123	Testis_brain_RNA-binding_protein	83,115	TB-RBP	Testis brain RNA-binding protein	22099(Tax:10090)	22099(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Elevated levels of the polyadenylation factor CstF_64 enhance formation of the 1kB Testis_brain_RNA-binding_protein -LRB- TB-RBP -RRB- mRNA in male germ cells .
14711818	0	TB-RBP	88,94	Translin-associated_factor_X	0,28	TB-RBP	Translin-associated factor X	22099(Tax:10090)	53424(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Translin-associated_factor_X is post-transcriptionally regulated by its partner protein TB-RBP , and both are essential for normal cell proliferation .
11278549	0	TB-RBP	94,100	Trax	0,4	TB-RBP	Trax	7247	7257	Gene	Gene	the|nmod|START_ENTITY inhibits|dobj|the inhibits|nsubj|END_ENTITY	Trax -LRB- translin-associated_factor_X -RRB- , a primarily cytoplasmic protein , inhibits the binding of TB-RBP -LRB- translin -RRB- to RNA .
11278549	0	TB-RBP	94,100	translin-associated_factor_X	6,34	TB-RBP	translin-associated factor X	7247	7257	Gene	Gene	the|nmod|START_ENTITY inhibits|dobj|the inhibits|nsubj|Trax Trax|appos|END_ENTITY	Trax -LRB- translin-associated_factor_X -RRB- , a primarily cytoplasmic protein , inhibits the binding of TB-RBP -LRB- translin -RRB- to RNA .
19542357	0	TBC-2	41,46	RAB-5	111,116	TBC-2	RAB-5	173986(Tax:6239)	172755(Tax:6239)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	C. _ elegans Rab GTPase activating protein TBC-2 promotes cell corpse degradation by regulating the small GTPase RAB-5 .
9618176	0	TBC1	22,26	NB4S	0,4	TBC1	NB4S	23216	7813	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	NB4S , a member of the TBC1 domain family of genes , is truncated as a result of a constitutional t -LRB- 1 ; 10 -RRB- -LRB- p22 ; q21 -RRB- chromosome translocation in a patient with stage 4S neuroblastoma .
18215134	0	TBC1D1	14,20	GLUT1	31,36	TBC1D1	GLUT1	23216	6513	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes .
18215134	0	TBC1D1	14,20	mTOR	60,64	TBC1D1	mTOR	23216	21977(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes .
22854040	0	TBC1D17	83,90	Optineurin	0,10	TBC1D17	Optineurin	79735	10133	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Optineurin mediates a negative regulation of Rab8 by the GTPase-activating protein TBC1D17 .
21454505	0	TBC1D4	39,45	AS160	47,52	TBC1D4	AS160	9882	9882	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Crystal structures of human TBC1D1 and TBC1D4 -LRB- AS160 -RRB- RabGTPase-activating protein -LRB- RabGAP -RRB- domains reveal critical elements for GLUT4 translocation .
22466139	0	TBC1D4	54,60	AS160	62,67	TBC1D4	AS160	210789(Tax:10090)	210789(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunofluorescent localization of the Rab-GAP protein TBC1D4 -LRB- AS160 -RRB- in mouse kidney .
22732222	0	TBC1D4	17,23	AS160	25,30	TBC1D4	AS160	9882	9882	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Affinity between TBC1D4 -LRB- AS160 -RRB- phosphotyrosine-binding domain and insulin-regulated_aminopeptidase cytoplasmic domain measured by isothermal titration calorimetry .
25232007	0	TBC1D9B	0,7	Rab11a	53,59	TBC1D9B	Rab11a	481460(Tax:9615)	403957(Tax:9615)	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells .
22880023	0	TBCA	38,42	tubulin_cofactor_A	18,36	TBCA	tubulin cofactor A	21371(Tax:10090)	21371(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of tubulin_cofactor_A -LRB- TBCA -RRB- is regulated by a noncoding antisense Tbca RNA during testis maturation .
2834383	0	TBE-1	61,66	H-ras	0,5	TBE-1	H-ras	4313	3265	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	H-ras oncogene-transformed human bronchial epithelial cells -LRB- TBE-1 -RRB- secrete a single metalloprotease capable of degrading basement membrane collagen .
11916615	0	TBG	54,57	thyroxine-binding_globulin	26,52	TBG	thyroxine-binding globulin	6906	6906	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two novel variants in the thyroxine-binding_globulin -LRB- TBG -RRB- gene behind the diagnosis of TBG_deficiency .
6201364	0	TBG	51,54	thyroxine-binding_globulin	23,49	TBG	thyroxine-binding globulin	6906	6906	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Clinical evaluation of thyroxine-binding_globulin -LRB- TBG -RRB- as a marker of liver_tumors .
25780039	0	TBK1	37,41	APPL1	11,16	TBK1	APPL1	29110	26060	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	A Role for APPL1 in TLR3/4-Dependent TBK1 and IKK Activation in Macrophages .
26976762	0	TBK1	14,18	Optineurin	31,41	TBK1	Optineurin	29110	10133	Gene	Gene	activity|nummod|START_ENTITY activity|nmod|END_ENTITY	Regulation of TBK1 activity by Optineurin contributes to cell cycle-dependent expression of the interferon pathway .
25939384	0	TBK1	40,44	SOCS3	0,5	TBK1	SOCS3	29110	9021	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|compound|END_ENTITY	SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity .
26358190	0	TBK1	64,68	TRIM27	106,112	TBK1	TRIM27	29110	5987	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27 .
18307994	0	TBK1	20,24	optineurin	31,41	TBK1	optineurin	29110	10133	Gene	Gene	Enhanced|nmod|START_ENTITY Enhanced|nmod|mutant mutant|compound|END_ENTITY	Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle_glaucoma .
27086836	0	TBK1	4,8	optineurin	27,37	TBK1	optineurin	56480(Tax:10090)	71648(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The TBK1 binding domain of optineurin promotes type I interferon responses .
27073743	0	TBL1	31,35	Ebi	0,3	TBL1	Ebi	33212(Tax:7227)	33212(Tax:7227)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Ebi , a Drosophila homologue of TBL1 , regulates the balance between cellular defense responses and neuronal survival .
15834507	0	TBL1X	53,58	TBL1Y	22,27	TBL1X	TBL1Y	6907	90665	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Molecular analysis of TBL1Y , a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural_deafness .
15834507	0	TBL1Y	22,27	TBL1X	53,58	TBL1Y	TBL1X	90665	6907	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Molecular analysis of TBL1Y , a Y-linked homologue of TBL1X related with X-linked late-onset sensorineural_deafness .
23564352	0	TBL2	47,51	TERE1	4,9	TBL2	TERE1	26608	29914	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The TERE1 protein interacts with mitochondrial TBL2 : regulation of trans-membrane potential , ROS/RNS and SXR target genes .
9161404	0	TBM	55,58	tracheo-bronchial_mucin	30,53	TBM	tracheo-bronchial mucin	4586	4586	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of tracheo-bronchial_mucin -LRB- TBM -RRB- gene by ethanol .
8087622	0	TBP	107,110	EB1	68,71	TBP	EB1	6908	22919	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The bZIP motif of the Epstein-Barr_virus _ -LRB- EBV -RRB- transcription factor EB1 mediates a direct interaction with TBP .
17074809	0	TBP	0,3	JNK1	62,66	TBP	JNK1	6908	5599	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	TBP is differentially regulated by c-Jun N-terminal kinase 1 -LRB- JNK1 -RRB- and JNK2 through Elk-1 , controlling c-Jun expression and cell proliferation .
26258880	0	TBP	55,58	NC2	63,66	TBP	NC2	6908	1810	Gene	Gene	basis|nmod|START_ENTITY END_ENTITY|nsubj|basis	Structural basis for recognition and remodeling of the TBP : DNA : NC2 complex by Mot1 .
8502484	0	TBP	76,79	TATA-binding_protein	54,74	TBP	TATA-binding protein	6908	6908	Gene	Gene	complexes|appos|START_ENTITY complexes|amod|END_ENTITY	p300 , and p300-associated proteins , are components of TATA-binding_protein -LRB- TBP -RRB- complexes .
8568841	0	TBP	74,77	TATA-binding_protein	52,72	TBP	TATA-binding protein	6908	6908	Gene	Gene	interactions|appos|START_ENTITY interactions|amod|END_ENTITY	Patch clamp and atomic force microscopy demonstrate TATA-binding_protein -LRB- TBP -RRB- interactions with the nuclear_pore_complex .
8769130	0	TBP	54,57	TATA-binding_protein	32,52	TBP	TATA-binding protein	21374(Tax:10090)	21374(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Promoter structure of the mouse TATA-binding_protein -LRB- TBP -RRB- gene .
11259579	0	TBP	30,33	TATA_binding_protein	8,28	TBP	TATA binding protein	856891(Tax:4932)	856891(Tax:4932)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of TATA_binding_protein -LRB- TBP -RRB- in yeast ribosomal dna transcription by RNA polymerase I : defects in the dual functions of transcription factor UAF can not be suppressed by TBP .
10672937	0	TBP	72,75	TATA_box-binding_protein	77,101	TBP	TATA box-binding protein	37476(Tax:7227)	37476(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	An element with palindromic structure is required for the expression of TBP -LRB- TATA_box-binding_protein -RRB- gene in Drosophila_melanogaster .
19581089	0	TBP	51,54	TATA_box-binding_protein	25,49	TBP	TATA box-binding protein	6908	6908	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the TATA_box-binding_protein -LRB- TBP -RRB- gene in Chinese Han patients with spinocerebellar_ataxia .
7873754	0	TBP	54,57	TATA_box-binding_protein	28,52	TBP	TATA box-binding protein	6908	6908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Direct mapping of the human TATA_box-binding_protein -LRB- TBP -RRB- gene to 6q27 by fluorescence in situ hybridization .
15062100	0	TBP	42,45	TBP2	0,4	TBP	TBP2	368882(Tax:7955)	407713(Tax:7955)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	TBP2 , a vertebrate-specific member of the TBP family , is required in embryonic development of zebrafish .
19650908	0	TBP	25,28	TBP2	0,4	TBP	TBP2	399465(Tax:8355)	387333(Tax:8355)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	TBP2 is a substitute for TBP in Xenopus oocyte transcription .
8109176	0	TBP-1	85,90	Cdc48p	77,83	TBP-1	Cdc48p	856891(Tax:4932)	851431(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	TBP-1	85,90	Pas1p	70,75	TBP-1	Pas1p	856891(Tax:4932)	853636(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
8109176	0	TBP-1	85,90	Sec18p	62,68	TBP-1	Sec18p	856891(Tax:4932)	852372(Tax:4932)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	AFG2 , an essential gene in yeast , encodes a new member of the Sec18p , Pas1p , Cdc48p , TBP-1 family of putative ATPases .
19325002	0	TBP-1	23,28	androgen_receptor	101,118	TBP-1	androgen receptor	5702	367	Gene	Gene	Tat-binding_protein-1|appos|START_ENTITY enhances|nsubj|Tat-binding_protein-1 enhances|dobj|function function|compound|END_ENTITY	Tat-binding_protein-1 -LRB- TBP-1 -RRB- , an ATPase of 19S regulatory particles of the 26S proteasome , enhances androgen_receptor function in cooperation with TBP-1-interacting_protein / Hop2 .
17334400	0	TBP-1	0,5	p14ARF	40,46	TBP-1	p14ARF	5702	1029	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation .
12207886	0	TBP-interacting_protein_120B	0,28	NOT3	83,87	TBP-interacting protein 120B	NOT3	67088(Tax:10090)	4849	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	TBP-interacting_protein_120B , which is induced in relation to myogenesis , binds to NOT3 .
17109819	0	TBP-related_factor_2	53,73	wee1	40,44	TBP-related factor 2	wee1	237336(Tax:10090)	22390(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|gene gene|amod|END_ENTITY	Transcriptional repression of the mouse wee1 gene by TBP-related_factor_2 .
17641088	0	TBP2	36,40	TATA-binding_protein	12,32	TBP2	TATA-binding protein	56338(Tax:10090)	21374(Tax:10090)	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of TATA-binding_protein 2 -LRB- TBP2 -RRB- and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development .
15062100	0	TBP2	0,4	TBP	42,45	TBP2	TBP	407713(Tax:7955)	368882(Tax:7955)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	TBP2 , a vertebrate-specific member of the TBP family , is required in embryonic development of zebrafish .
19650908	0	TBP2	0,4	TBP	25,28	TBP2	TBP	387333(Tax:8355)	399465(Tax:8355)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	TBP2 is a substitute for TBP in Xenopus oocyte transcription .
21285371	0	TBR1	0,4	Fezf2	24,29	TBR1	Fezf2	10716	55079	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract .
27026770	0	TBX-5	62,67	T-box_transcription_factor-5	32,60	TBX-5	T-box transcription factor-5	6910	6910	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutated sequence in the T-box_transcription_factor-5 -LRB- TBX-5 -RRB- gene -LRB- c. 241A > T -RRB- in Holt-Oram_syndrome .
26382615	0	TBX1	0,4	Vegfr2	15,21	TBX1	Vegfr2	6899	3791	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2 + Cells .
20110314	0	TBX18	31,36	SIX1	0,4	TBX18	SIX1	9096	6495	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation .
26971330	0	TBX2	25,29	Oca2	83,87	TBX2	Oca2	21385(Tax:10090)	18431(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|repressing repressing|dobj|END_ENTITY	The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2 .
23020925	0	TBX2	0,4	PAX3	32,36	TBX2	PAX3	6909	5077	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	TBX2 expression is regulated by PAX3 in the melanocyte lineage .
26686089	0	TBX2	0,4	PTEN	15,19	TBX2	PTEN	6909	5728	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle .
12000749	0	TBX2	21,25	p14ARF	83,89	TBX2	p14ARF	6909	1029	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator .
18275040	0	TBX20	20,25	TFAP2	64,69	TBX20	TFAP2	57057	7020	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of TBX20 in human hearts and its regulation by TFAP2 .
24499286	0	TBX21	114,119	T-bet	121,126	TBX21	T-bet	57765(Tax:10090)	57765(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor , TBX21 -LRB- T-bet -RRB- .
25292313	0	TBX21	78,83	galectin-1	15,25	TBX21	galectin-1	30009	3956	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of galectin-1 on the gene expression of the transcription factors TBX21 , GATA-3 , FOXP3 and RORC .
24025717	0	TBX3	14,18	TGF-b1	62,68	TBX3	TGF-b1	6926	7040	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The oncogenic TBX3 is a downstream target and mediator of the TGF-b1 signaling pathway .
25158279	0	TBX3	0,4	TGF-b1	29,35	TBX3	TGF-b1	6926	7040	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	TBX3 , a downstream target of TGF-b1 , inhibits mesangial cell apoptosis .
25371204	0	TBX3	127,131	TGF-b1	39,45	TBX3	TGF-b1	6926	7040	Gene	Gene	Involves|nmod|START_ENTITY Involves|nsubj|Function Function|nmod|Pathway Pathway|compound|END_ENTITY	The Anti-proliferative Function of the TGF-b1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3 .
19648116	0	TBX5	42,46	SC35	112,116	TBX5	SC35	6910	6427	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram_syndrome via association with SC35 .
22728936	0	TBX5	0,4	Scn5a	12,17	TBX5	Scn5a	6910	6331	Gene	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|amod|END_ENTITY	TBX5 drives Scn5a expression to regulate cardiac conduction system function .
21070398	0	TBXA2R	40,46	thromboxane_A2_receptor	15,38	TBXA2R	thromboxane A2 receptor	6915	6915	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of thromboxane_A2_receptor -LRB- TBXA2R -RRB- gene polymorphism in patients with aspirin-intolerant acute urticaria .
12867545	0	TB_G6	52,57	beta-galactosidase	27,45	TB G6	beta-galactosidase	543612(Tax:4081)	543610(Tax:4081)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Antisense suppression of a beta-galactosidase gene -LRB- TB_G6 -RRB- in tomato increases fruit cracking .
23759247	0	TC-PTP	12,18	PTPN2	20,25	TC-PTP	PTPN2	5771	5771	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of TC-PTP -LRB- PTPN2 -RRB- in modulating sensitivity to imatinib and interferon-a in CML cell line , KT-1 cells .
11773439	0	TC-PTP	219,225	TC-PTP	39,45	TC-PTP	TC-PTP	5771	5771	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway : dephosphorylation and deactivation of signal_transducer_and_activator_of_transcription_5a and 5b by TC-PTP in nucleus .
11773439	0	TC-PTP	39,45	TC-PTP	219,225	TC-PTP	TC-PTP	5771	5771	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway : dephosphorylation and deactivation of signal_transducer_and_activator_of_transcription_5a and 5b by TC-PTP in nucleus .
25869879	0	TC1	23,26	C8orf4	28,34	TC1	C8orf4	56892	56892	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The high expression of TC1 -LRB- C8orf4 -RRB- was correlated with the expression of b-catenin and cyclin_D1 and the progression of squamous_cell_carcinomas of the tongue .
16730711	0	TC1	0,3	TNF-alpha	39,48	TC1	TNF-alpha	56892	7124	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	TC1 -LRB- C8orf4 -RRB- is upregulated by IL-1beta / TNF-alpha and enhances proliferation of human follicular dendritic cells .
12912916	0	TC10	67,71	Insulin	0,7	TC10	Insulin	23433	3630	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation .
19274320	0	TC2	97,100	transcobalamin_2	79,95	TC2	transcobalamin 2	6948	6948	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	A80G polymorphism of reduced folate carrier 1 -LRB- RFC1 -RRB- and C776G polymorphism of transcobalamin_2 -LRB- TC2 -RRB- genes in Down 's _ syndrome etiology .
9469461	0	TCA-3	158,163	CCR8	133,137	TCA-3	CCR8	20290(Tax:10090)	12776(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	Identification of CCR8 as the specific receptor for the human beta-chemokine I-309 : cloning and molecular characterization of murine CCR8 as the receptor for TCA-3 .
11195349	0	TCAM-1	100,106	testicular_cell_adhesion_molecule-1	63,98	TCAM-1	testicular cell adhesion molecule-1	75870(Tax:10090)	75870(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Structure , expression , and conserved physical linkage of mouse testicular_cell_adhesion_molecule-1 -LRB- TCAM-1 -RRB- gene .
9441762	0	TCEA2	53,58	TFIIS	46,51	TCEA2	TFIIS	6919	6919	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic characterization of a testis-specific TFIIS -LRB- TCEA2 -RRB- gene .
18806825	0	TCEAL7	43,49	c-Myc	71,76	TCEAL7	c-Myc	56849	4609	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity , cyclin_D1 levels and cellular transformation .
21503969	0	TCERG1	0,6	C/EBPa	16,22	TCERG1	C/EBPa	10915	1050	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	TCERG1 inhibits C/EBPa through a mechanism that does not involve sequestration of C/EBPa at pericentromeric heterochromatin .
21503969	0	TCERG1	0,6	C/EBPa	82,88	TCERG1	C/EBPa	10915	1050	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|mechanism mechanism|acl:relcl|involve involve|dobj|sequestration sequestration|nmod|END_ENTITY	TCERG1 inhibits C/EBPa through a mechanism that does not involve sequestration of C/EBPa at pericentromeric heterochromatin .
26264132	0	TCERG1	39,45	C/EBPa	110,116	TCERG1	C/EBPa	10915	1050	Gene	Gene	Domain|nmod|START_ENTITY Required|nsubjpass|Domain Required|nmod|Inhibition Inhibition|nmod|Activity Activity|nmod|END_ENTITY	The Glutamine-Alanine Repeat Domain of TCERG1 is Required for the Inhibition of the Growth Arrest Activity of C/EBPa .
11309309	0	TCF	32,35	beta-catenin	19,31	TCF	beta-catenin	3172	1499	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation .
15514942	0	TCF	97,100	beta-catenin	83,95	TCF	beta-catenin	3172	1499	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Overexpression of human pituitary_tumor_transforming_gene -LRB- hPTTG -RRB- , is regulated by beta-catenin / TCF pathway in human esophageal_squamous_cell_carcinoma .
15525529	0	TCF	97,100	beta-catenin	79,91	TCF	beta-catenin	3172	1499	Gene	Gene	divert|nmod|START_ENTITY divert|dobj|END_ENTITY	The APC_tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF .
20348951	0	TCF	13,16	beta-catenin	61,73	TCF	beta-catenin	3172	1499	Gene	Gene	signaling|nsubj|START_ENTITY signaling|advcl|blocking blocking|dobj|expression expression|amod|END_ENTITY	PKG inhibits TCF signaling in colon_cancer cells by blocking beta-catenin expression and activating FOXO4 .
21935461	0	TCF-1	17,22	IL-17	44,49	TCF-1	IL-17	21414(Tax:10090)	16171(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|compound|END_ENTITY	Critical role of TCF-1 in repression of the IL-17 gene .
20980261	0	TCF-1	43,48	T_cell_factor_1	26,41	TCF-1	T cell factor 1	6932	6932	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of suppressive T_cell_factor_1 -LRB- TCF-1 -RRB- isoforms in naive CD4 + T cells is mediated by IL-4 / STAT6 signaling .
20056134	0	TCF-4	83,88	Wnt	51,54	TCF-4	Wnt	84382(Tax:10116)	114487(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Insulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cells .
12861022	0	TCF-4	52,57	beta-catenin	75,87	TCF-4	beta-catenin	21413(Tax:10090)	12387(Tax:10090)	Gene	Gene	isoform|nmod|START_ENTITY factor|appos|isoform synergizes|nsubj|factor synergizes|nmod|END_ENTITY	T-cell factor 4N -LRB- TCF-4N -RRB- , a novel isoform of mouse TCF-4 , synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic_factor_1 transcription factors .
15525634	0	TCF-4	0,5	beta-catenin	79,91	TCF-4	beta-catenin	6925	1499	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen_synthase_kinase-3beta .
20122174	0	TCF-4	19,24	beta-catenin	43,55	TCF-4	beta-catenin	6934	1499	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Axin downregulates TCF-4 transcription via beta-catenin , but not p53 , and inhibits the proliferation and invasion of lung_cancer cells .
9784592	0	TCF-4	0,5	beta-catenin	12,24	TCF-4	beta-catenin	21413(Tax:10090)	12387(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs .
26642437	0	TCF1	0,4	GIPR	11,15	TCF1	GIPR	21414(Tax:10090)	381853(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	TCF1 links GIPR signaling to the control of beta cell function and survival .
20509872	0	TCF2	84,88	CDKAL1	52,58	TCF2	CDKAL1	6928	54901	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	TCF2	84,88	CDKN2A/B	60,68	TCF2	CDKN2A/B	6928	1029;1030	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	TCF2	84,88	FTO	79,82	TCF2	FTO	6928	79068	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	TCF2	84,88	HHEX	46,50	TCF2	HHEX	6928	3087	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	TCF2	84,88	IGF2BP2	70,77	TCF2	IGF2BP2	6928	10644	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|appos|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
20509872	0	TCF2	84,88	SLC30A8	37,44	TCF2	SLC30A8	6928	169026	Gene	Gene	KCNQ1|appos|START_ENTITY KCNQ1|compound|END_ENTITY	Implication of genetic variants near SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , FTO , TCF2 , KCNQ1 , and WFS1_in_type_2_diabetes in a Chinese population .
12161522	0	TCF2	84,88	hepatocyte_nuclear_factor-1_beta	45,77	TCF2	hepatocyte nuclear factor-1 beta	6928	6928	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Nonsense and missense mutations in the human hepatocyte_nuclear_factor-1_beta gene -LRB- TCF2 -RRB- and their relation to type 2 diabetes in Japanese .
16249435	0	TCF2	69,73	hepatocyte_nuclear_factor-1beta	36,67	TCF2	hepatocyte nuclear factor-1beta	6928	6928	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Large genomic rearrangements in the hepatocyte_nuclear_factor-1beta -LRB- TCF2 -RRB- gene are the most frequent cause of maturity-onset diabetes_of_the_young_type_5 .
26421305	0	TCF21	6,11	SHP	20,23	TCF21	SHP	6943	8431	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	POD-1 / TCF21 Reduces SHP Expression , Affecting LRH-1 Regulation and Cell Cycle Balance in Adrenocortical and Hepatocarcinoma_Tumor Cells .
26029241	0	TCF3	34,38	E2A	40,43	TCF3	E2A	6929	6929	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sites of instability in the human TCF3 -LRB- E2A -RRB- gene adopt G-quadruplex DNA structures in vitro .
21725619	0	TCF3	0,4	Oct4	70,74	TCF3	Oct4	21415(Tax:10090)	100846986	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	TCF3 inhibits F9 embryonal_carcinoma growth by the down-regulation of Oct4 .
25721714	0	TCF4	46,50	CD36	26,30	TCF4	CD36	6925	948	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-y in Macrophages .
25217366	0	TCF4	46,50	MIR137	38,44	TCF4	MIR137	6925	406928	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	No effect of schizophrenia risk genes MIR137 , TCF4 , and ZNF804A on macroscopic brain structure .
26350900	0	TCF4	91,95	RNF43	14,19	TCF4	RNF43	6934	54894	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated b-catenin by sequestering TCF4 to the nuclear membrane .
25721714	0	TCF4	46,50	Wnt1	0,4	TCF4	Wnt1	6925	7471	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-y in Macrophages .
22231735	0	TCF4	86,90	b-catenin	42,51	TCF4	b-catenin	6925	1499	Gene	Gene	upregulation|nmod|START_ENTITY signaling|nmod|upregulation functions|acl|signaling functions|nmod|regulator regulator|nmod|END_ENTITY	Sox4 functions as a positive regulator of b-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial_carcinomas .
24982424	0	TCF4	102,106	b-catenin	91,100	TCF4	b-catenin	6925	1499	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	CREPT/RPRD1B , a recently identified novel protein highly expressed in tumors , enhances the b-catenin TCF4 transcriptional activity in response to Wnt signaling .
26350900	0	TCF4	91,95	b-catenin	65,74	TCF4	b-catenin	6934	1499	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|downstream downstream|nmod|END_ENTITY	The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated b-catenin by sequestering TCF4 to the nuclear membrane .
23185296	0	TCF4	75,79	transcription_factor_4	51,73	TCF4	transcription factor 4	6925	6925	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common trinucleotide repeat expansion within the transcription_factor_4 -LRB- TCF4 , E2-2 -RRB- gene predicts Fuchs_corneal_dystrophy .
18469204	0	TCF7L2	37,43	CDKAL1	60,66	TCF7L2	CDKAL1	6934	54901	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
22487833	0	TCF7L2	50,56	CDKAL1	58,64	TCF7L2	CDKAL1	6934	54901	Gene	Gene	genes|compound|START_ENTITY genes|nummod|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
20424228	0	TCF7L2	44,50	CDKN2A	67,73	TCF7L2	CDKN2A	6934	1029	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
18469204	0	TCF7L2	37,43	CDKN2A/B	68,76	TCF7L2	CDKN2A/B	6934	1029;1030	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
18469204	0	TCF7L2	37,43	HHEX	54,58	TCF7L2	HHEX	6934	3087	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20424228	0	TCF7L2	44,50	HHEX	61,65	TCF7L2	HHEX	6934	3087	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
22487833	0	TCF7L2	50,56	HHEX	75,79	TCF7L2	HHEX	6934	3087	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
20424228	0	TCF7L2	44,50	KCNJ11	36,42	TCF7L2	KCNJ11	6934	3767	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
20597906	0	TCF7L2	62,68	KCNJ11	76,82	TCF7L2	KCNJ11	6934	3767	Gene	Gene	HHEX|nummod|START_ENTITY HHEX|nummod|END_ENTITY	A validation study of type_2_diabetes-related variants of the TCF7L2 , HHEX , KCNJ11 , and ADIPOQ genes in one endogamous ethnic group of north India .
20424228	0	TCF7L2	44,50	PPARG	29,34	TCF7L2	PPARG	6934	5468	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|compound|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
18469204	0	TCF7L2	37,43	SLC30A8	45,52	TCF7L2	SLC30A8	6934	169026	Gene	Gene	IGF2BP2|compound|START_ENTITY IGF2BP2|appos|END_ENTITY	Implication of genetic variants near TCF7L2 , SLC30A8 , HHEX , CDKAL1 , CDKN2A/B , IGF2BP2 , and FTO in type 2 diabetes and obesity in 6,719 Asians .
20424228	0	TCF7L2	44,50	SLC30A8	52,59	TCF7L2	SLC30A8	6934	169026	Gene	Gene	IGF2BP2|appos|START_ENTITY IGF2BP2|appos|END_ENTITY	Impact of common variants of PPARG , KCNJ11 , TCF7L2 , SLC30A8 , HHEX , CDKN2A , IGF2BP2 , and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians .
22487833	0	TCF7L2	50,56	SLC30A8	66,73	TCF7L2	SLC30A8	6934	169026	Gene	Gene	genes|compound|START_ENTITY genes|nummod|END_ENTITY	-LSB- Association analysis of genetic polymorphisms of TCF7L2 , CDKAL1 , SLC30A8 , HHEX genes and microvascular complications of type_2_diabetes_mellitus -RSB- .
26590303	0	TCF7L2	37,43	TMEPAI	18,24	TCF7L2	TMEPAI	6934	56937	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Regulation of the TMEPAI promoter by TCF7L2 : the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene .
26986145	0	TCF7L2	50,56	Transcription_Factor_7_Like_2	19,48	TCF7L2	Transcription Factor 7 Like 2	6934	6934	Gene	Gene	Polymorphism|appos|START_ENTITY Polymorphism|compound|END_ENTITY	Association of the Transcription_Factor_7_Like_2 -LRB- TCF7L2 -RRB- Polymorphism With Diabetic_Nephropathy Risk : A Meta-Analysis .
18931037	0	TCF7L2	31,37	Transcription_factor_7-like_2	0,29	TCF7L2	Transcription factor 7-like 2	6934	6934	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults : the Atherosclerosis Risk in Communities study .
20578204	0	TCF7L2	31,37	Transcription_factor_7-like_2	0,29	TCF7L2	Transcription factor 7-like 2	6934	6934	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- polymorphism and context-specific risk of impaired_fasting_glucose in African American and Caucasian adults : the atherosclerosis risk in communities -LRB- ARIC -RRB- study .
24529562	0	TCF7L2	31,37	Transcription_factor_7-like_2	0,29	TCF7L2	Transcription factor 7-like 2	6934	6934	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration .
18481957	0	TCF7L2	0,6	insulin	16,23	TCF7L2	insulin	6934	3630	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells .
24157263	0	TCF7L2	48,54	transcription_factor-7-like_2	17,46	TCF7L2	transcription factor-7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms of transcription_factor-7-like_2 -LRB- TCF7L2 -RRB- gene in Tunisian women with polycystic_ovary_syndrome -LRB- PCOS -RRB- .
16936216	0	TCF7L2	42,48	transcription_factor_7-like_2	11,40	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variant of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and the risk of type 2 diabetes in large cohorts of U.S. women and men .
16936218	0	TCF7L2	52,58	transcription_factor_7-like_2	21,50	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene are associated with type 2 diabetes in the Amish : replication and evidence for a role in both insulin secretion and insulin resistance .
17130514	0	TCF7L2	51,57	transcription_factor_7-like_2	20,49	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with reduced insulin secretion in nondiabetic women .
17259383	0	TCF7L2	45,51	transcription_factor_7-like_2	14,43	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Haplotypes of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans .
17342473	0	TCF7L2	48,54	transcription_factor_7-like_2	17,46	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A variant in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with an increased risk of gestational_diabetes_mellitus .
17579206	0	TCF7L2	85,91	transcription_factor_7-like_2	54,83	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of the genetic polymorphisms of the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and type 2 diabetes in the Chinese population .
17601994	0	TCF7L2	47,53	transcription_factor_7-like_2	16,45	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene are associated with type 2 diabetes in an African-American population enriched for nephropathy .
17725629	0	TCF7L2	35,41	transcription_factor_7-like_2	4,33	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with Type 2 diabetes in UK community-based cases , but the risk allele frequency is reduced compared with UK cases selected for genetic studies .
17934151	0	TCF7L2	48,54	transcription_factor_7-like_2	17,46	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A variant of the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and the risk of posttransplantation diabetes_mellitus in renal allograft recipients .
18302196	0	TCF7L2	62,68	transcription_factor_7-like_2	31,60	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of a variant in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and prostate_cancer risk in a population-based study .
21301999	0	TCF7L2	53,59	transcription_factor_7-like_2	22,51	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variations in transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene : association of TCF7L2 rs12255372 -LRB- G/T -RRB- or rs7903146 -LRB- C/T -RRB- with breast_cancer risk and clinico-pathological parameters .
21399856	0	TCF7L2	43,49	transcription_factor_7-like_2	12,41	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and incident glucose_intolerance in Japanese-Brazilians .
21855162	0	TCF7L2	49,55	transcription_factor_7-like_2	18,47	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- in fat and placental tissue from women with gestational_diabetes .
23855352	0	TCF7L2	76,82	transcription_factor_7-like_2	45,74	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the rs7903146 polymorphism in transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene with gestational_diabetes_mellitus : a meta-analysis .
25934528	0	TCF7L2	51,57	transcription_factor_7-like_2	20,49	TCF7L2	transcription factor 7-like 2	6934	6934	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with impaired_proinsulin_conversion-A meta-analysis .
18172091	0	TCF8	65,69	posterior_polymorphous_corneal_dystrophy_3	16,58	TCF8	posterior polymorphous corneal dystrophy 3	6935	6935	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the posterior_polymorphous_corneal_dystrophy_3 gene , TCF8 , in late-onset Fuchs_endothelial_corneal_dystrophy .
6424951	0	TCGF	40,44	T-cell_growth_factor	18,38	TCGF	T-cell growth factor	443401(Tax:9940)	443401(Tax:9940)	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	The production of T-cell_growth_factor -LRB- TCGF -RRB- in vivo in sheep .
6609319	0	TCGF	12,16	T-cell_growth_factor	18,38	TCGF	T-cell growth factor	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of TCGF -LRB- T-cell_growth_factor -RRB- on experimental malignant_glioma-specific killer T-cell -RSB- .
6300245	0	TCGF	121,125	T_cell_growth_factor	99,119	TCGF	T cell growth factor	3558	3558	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Viral inhibition of lymphocyte mitogenesis : interference with the synthesis of functionally active T_cell_growth_factor -LRB- TCGF -RRB- activity and reversal of inhibition by the addition of same .
6788848	2	TCGF	121,125	mast_cell_growth_factor	71,94	TCGF	mast cell growth factor	16183(Tax:10090)	16187(Tax:10090)	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification of a mast_cell_growth_factor and its dissociation from TCGF .
12009899	0	TCL1	36,40	AKT	79,82	TCL1	AKT	8115	207	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane .
24379361	0	TCL1	23,27	ROR1	0,4	TCL1	ROR1	21432(Tax:10090)	26563(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	ROR1 can interact with TCL1 and enhance leukemogenesis in E - TCL1 transgenic_mice .
16568240	0	TCP-1	48,53	Caveolin-1	0,10	TCP-1	Caveolin-1	6950	857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Caveolin-1 interacts with the chaperone complex TCP-1 and modulates its protein folding activity .
21822059	0	TCP1	0,4	DWF4	44,48	TCP1	DWF4	821544(Tax:3702)	824229(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	TCP1 positively regulates the expression of DWF4 in Arabidopsis_thaliana .
26233893	0	TCP1	0,4	DWF4	105,109	TCP1	DWF4	821544(Tax:3702)	824229(Tax:3702)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Region Region|nmod|END_ENTITY	TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis_thaliana .
26233893	0	TCP1	0,4	DWF4	15,19	TCP1	DWF4	821544(Tax:3702)	824229(Tax:3702)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TCP1 Modulates DWF4 Expression via Directly Interacting with the GGNCCC Motifs in the Promoter Region of DWF4 in Arabidopsis_thaliana .
3653076	0	TCP1	49,53	t-complex	33,42	TCP1	t-complex	21454(Tax:10090)	20998(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human homologue of the mouse t-complex gene , TCP1 , is located on chromosome 6 but is not near the HLA region .
26698869	0	TCP10L	0,6	MAD1	23,27	TCP10L	MAD1	140290	4084	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction .
15469726	0	TCP10L	44,50	MAD4	60,64	TCP10L	MAD4	140290	10608	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human liver specific transcriptional factor TCP10L binds to MAD4 .
15910542	0	TCP10L	0,6	death_associated_protein_kinase-3	69,102	TCP10L	death associated protein kinase-3	140290	1613	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	TCP10L is expressed specifically in spermatogenic cells and binds to death_associated_protein_kinase-3 .
15592458	0	TCPTP	120,125	EGFR	23,27	TCPTP	EGFR	5771	1956	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP .
22159501	0	TCPTP	72,77	T-cell_protein_tyrosine_phosphatase	35,70	TCPTP	T-cell protein tyrosine phosphatase	5771	5771	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Potent and selective inhibition of T-cell_protein_tyrosine_phosphatase -LRB- TCPTP -RRB- by a dinuclear copper -LRB- II -RRB- complex .
23856547	0	TCPTP	60,65	T-cell_protein_tyrosine_phosphatase	23,58	TCPTP	T-cell protein tyrosine phosphatase	5771	5771	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	Molecular mechanism of T-cell_protein_tyrosine_phosphatase -LRB- TCPTP -RRB- activation by mitoxantrone .
12612081	0	TCPTP	77,82	insulin_receptor	14,30	TCPTP	insulin receptor	5771	3643	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of insulin_receptor signaling by the protein_tyrosine_phosphatase TCPTP .
17371994	0	TCR	15,18	Bcl10	0,5	TCR	Bcl10	6962	8915	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Bcl10 controls TCR - and FcgammaR-induced actin polymerization .
10569764	0	TCR	63,66	CD4	20,23	TCR	CD4	6962	920	Gene	Gene	T-cell-receptor-positive|dep|START_ENTITY alphabeta|dobj|T-cell-receptor-positive alphabeta|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of human CD4 -LRB- + -RRB- alphabeta T-cell-receptor-positive -LRB- TCR -LRB- + -RRB- -RRB- and gammadelta TCR -LRB- + -RRB- T-cell responses to Mycobacterium_tuberculosis by interleukin-10 and transforming growth factor beta .
11017105	0	TCR	64,67	CD4	0,3	TCR	CD4	6962	920	Gene	Gene	signaling|compound|START_ENTITY linked|nmod|signaling linked|nsubjpass|survival survival|compound|END_ENTITY	CD4 + T cell survival is not directly linked to self-MHC-induced TCR signaling .
12538680	0	TCR	0,3	CD4	34,37	TCR	CD4	6962	920	Gene	Gene	reserve|compound|START_ENTITY reserve|dep|principle principle|nmod|activation activation|compound|END_ENTITY	TCR reserve : a novel principle of CD4 T cell activation by weak ligands .
12694059	0	TCR	47,50	CD4	42,45	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	mouse|compound|START_ENTITY mouse|compound|END_ENTITY	Allograft rejection in a new allospecific CD4 + TCR transgenic mouse .
15322166	0	TCR	19,22	CD4	143,146	TCR	CD4	6962	920	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|cells cells|compound|END_ENTITY	Strong and durable TCR clustering at the T/dendritic cell immune synapse is not required for NFAT activation and IFN-gamma production in human CD4 + T cells .
15379980	0	TCR	79,82	CD4	25,28	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	T-cell_receptor|appos|START_ENTITY clones|nmod|T-cell_receptor clones|compound|END_ENTITY	Differential analysis of CD4 + Th memory clones with identical T-cell_receptor -LRB- TCR -RRB- - alphabeta rearrangement -LRB- non-transgenic -RRB- , but distinct lymphokine phenotype , reveals diverse and novel gene expression .
15496961	0	TCR	95,98	CD4	18,21	TCR	CD4	6962	920	Gene	Gene	transfer|compound|START_ENTITY requires|nmod|transfer requires|dep|Redirecting Redirecting|dobj|lymphocytes lymphocytes|compound|END_ENTITY	Redirecting human CD4 + T lymphocytes to the MHC class I-restricted melanoma antigen MAGE-A1 by TCR alphabeta gene transfer requires CD8alpha .
16236130	0	TCR	68,71	CD4	103,106	TCR	CD4	6962	920	Gene	Gene	clonotype|compound|START_ENTITY expressing|dobj|clonotype thymocytes|acl|expressing frequency|nmod|thymocytes regulates|nsubj|frequency regulates|dobj|homeostasis homeostasis|compound|END_ENTITY	The frequency of double-positive thymocytes expressing an alphabeta TCR clonotype regulates peripheral CD4 T cell compartment homeostasis .
16493062	0	TCR	92,95	CD4	107,110	TCR	CD4	6962	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Clonal competition inhibits the proliferation and differentiation of adoptively transferred TCR transgenic CD4 T cells in response to infection .
16887981	0	TCR	77,80	CD4	95,98	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY engagement|nmod|cells cells|compound|END_ENTITY	Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4 + T cells in steady-state homeostasis .
1690353	0	TCR	39,42	CD4	57,60	TCR	CD4	6962	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
1690353	0	TCR	39,42	CD4	91,94	TCR	CD4	6962	920	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression thymocytes|nsubj|regulation thymocytes|dep|influenced influenced|nmod|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
22370222	0	TCR	38,41	CD4	211,214	TCR	CD4	6962	920	Gene	Gene	cells|compound|START_ENTITY cultured|nsubj|cells cultured|ccomp|reflects reflects|dobj|activation activation|nmod|numbers numbers|nmod|T T|compound|END_ENTITY	The activation , by antigen , of na ve TCR transgenic CD4 T cells cultured at physiological , rather than artificially high , frequencies more accurately reflects the in vivo activation of normal numbers of na ve CD4 -LRB- + -RRB- T cells .
22370222	0	TCR	38,41	CD4	53,56	TCR	CD4	6962	920	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	The activation , by antigen , of na ve TCR transgenic CD4 T cells cultured at physiological , rather than artificially high , frequencies more accurately reflects the in vivo activation of normal numbers of na ve CD4 -LRB- + -RRB- T cells .
25462565	0	TCR	153,156	CD4	27,30	TCR	CD4	6962	920	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene T-cell|nmod|expression T-cell|nsubj|Visualization Visualization|nmod|END_ENTITY	Visualization of the human CD4 -LRB- + -RRB- T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/yc -LRB- null -RRB- -LRB- NOG -RRB- mice by retrogenic expression of the human TCR gene .
26010129	0	TCR	13,16	CD4	83,86	TCR	CD4	6962	920	Gene	Gene	drives|compound|START_ENTITY IL-2-dependent|nsubj|drives IL-2-dependent|dobj|maintenance maintenance|nmod|cells cells|compound|END_ENTITY	Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4 + T cells in aged humans .
7514632	0	TCR	95,98	CD4	71,74	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY lymphocytes|nmod|transgenic_mice lymphocytes|nsubj|dependence dependence|nmod|secretion secretion|nmod|T T|compound|END_ENTITY	Costimulator dependence of lymphokine secretion by naive and activated CD4 + T lymphocytes from TCR transgenic_mice .
7522245	0	TCR	87,90	CD4	18,21	TCR	CD4	6962	920	Gene	Gene	phosphorylation|compound|START_ENTITY activation|nmod|phosphorylation induces|dobj|activation induces|nsubj|ligation ligation|nmod|END_ENTITY	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation .
7867081	0	TCR	100,103	CD4	58,61	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY results|nmod|expression thymocytes|dobj|results thymocytes|nsubj|Disruption Disruption|nmod|interactions interactions|nmod|+ +|compound|END_ENTITY	Disruption of intrathymic CD4-Ia interactions on immature CD4 + CD8 + thymocytes results in diminished TCR expression on mature CD8 + T cell progeny .
7901153	0	TCR	65,68	CD4	0,3	TCR	CD4	6962	920	Gene	Gene	T-cell_antigen_receptor|appos|START_ENTITY comodulated|nmod|T-cell_antigen_receptor comodulated|nsubjpass|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7901153	0	TCR	65,68	CD4	92,95	TCR	CD4	6962	920	Gene	Gene	T-cell_antigen_receptor|appos|START_ENTITY comodulated|nmod|T-cell_antigen_receptor comodulated|nmod|activation activation|nmod|line line|compound|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
7915400	0	TCR	38,41	CD4	22,25	TCR	CD4	6962	920	Gene	Gene	ligation|compound|START_ENTITY +|nmod|ligation +|nsubj|selection selection|nmod|END_ENTITY	Positive selection of CD4 + T cells by TCR ligation without aggregation even in the absence of MHC .
8671590	0	TCR	93,96	CD4	62,65	TCR	CD4	6962	920	Gene	Gene	co-stimulation|compound|START_ENTITY absence|nmod|co-stimulation signaling|nmod|absence signaling|dobj|aberrancies aberrancies|nmod|cells cells|compound|END_ENTITY	HIV envelope-directed signaling aberrancies and cell death of CD4 + T cells in the absence of TCR co-stimulation .
8671613	0	TCR	70,73	CD4	46,49	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|nmod|cells cells|compound|END_ENTITY	Regulation of CD40_ligand expression on naive CD4 T cells : a role for TCR but not co-stimulatory signals .
8752910	0	TCR	0,3	CD4	26,29	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	triggering|compound|START_ENTITY triggering|nmod|cells cells|compound|END_ENTITY	TCR triggering of anergic CD4 T cells in murine AIDS induces apoptosis rather than cytokine synthesis and proliferation .
8921432	0	TCR	49,52	CD4	56,59	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressed|dobj|START_ENTITY expressed|nmod|END_ENTITY	Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4 + CD8 + thymocytes .
8921432	0	TCR	49,52	CD4	85,88	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressed|dobj|START_ENTITY expressed|nmod|thymocytes thymocytes|compound|END_ENTITY	Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4 + CD8 + thymocytes .
9016871	0	TCR	52,55	CD4	18,21	TCR	CD4	6962	920	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands .
9596673	0	TCR	49,52	CD4	64,67	TCR	CD4	6962	920	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|nummod|END_ENTITY	Viral superantigen-induced negative selection of TCR transgenic CD4 + CD8 + thymocytes depends on activation , but not proliferation .
9649213	0	TCR	73,76	CD4	68,71	TCR	CD4	6962	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	A pancolitis resembling human ulcerative_colitis -LRB- UC -RRB- is induced by CD4 + TCR alphabeta T cells of athymic origin in histocompatible severe_combined_immunodeficient -LRB- SCID -RRB- mice .
9796907	0	TCR	26,29	CD4	80,83	TCR	CD4	6962	920	Gene	Gene	lengths|compound|START_ENTITY distribution|nmod|lengths shifts|nsubj|distribution shifts|nmod|age age|nmod|END_ENTITY	The distribution of human TCR junctional region lengths shifts with age in both CD4 and CD8 T cells .
9831181	0	TCR	20,23	CD4	35,38	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	skewing|nmod|START_ENTITY +|nmod|skewing +|nsubj|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
9862685	0	TCR	116,119	CD4	148,151	TCR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Induction or protection from experimental_autoimmune_encephalomyelitis depends on the cytokine secretion profile of TCR peptide-specific regulatory CD4 T cells .
8671613	0	TCR	70,73	CD40_ligand	14,25	TCR	CD40 ligand	328483(Tax:10090)	21947(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of CD40_ligand expression on naive CD4 T cells : a role for TCR but not co-stimulatory signals .
8475386	0	TCR	14,17	CD45	31,35	TCR	CD45	328483(Tax:10090)	19264(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains .
10352247	0	TCR	175,178	CD8	117,120	TCR	CD8	6962	925	Gene	Gene	affinities|compound|START_ENTITY differences|nmod|affinities compensating|nmod|differences compensating|compound|END_ENTITY	Selection and long-term persistence of reactive CTL clones during an EBV chronic response are determined by avidity , CD8 variable contribution compensating for differences in TCR affinities .
11157474	0	TCR	194,197	CD8	210,213	TCR	CD8	6962	925	Gene	Gene	cells|appos|START_ENTITY cells|compound|END_ENTITY	Interferon-inducible_protein_10 , monokine_induced_by_interferon_gamma , and interferon-inducible_T-cell_alpha_chemoattractant are produced by thymic epithelial cells and attract T-cell_receptor -LRB- TCR -RRB- alphabeta + CD8 + single-positive T cells , TCRgammadelta + T cells , and natural killer-type cells in human thymus .
11165713	0	TCR	0,3	CD8	25,28	TCR	CD8	6962	925	Gene	Gene	stimulation|compound|START_ENTITY protects|nsubj|stimulation protects|dobj|cells cells|nummod|END_ENTITY	TCR stimulation protects CD8 + T cells from CD95 mediated apoptosis .
11675369	0	TCR	55,58	CD8	68,71	TCR	CD8	6962	925	Gene	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Influenza A antigen exposure selects dominant Vbeta17 + TCR in human CD8 + cytotoxic T cell responses .
12496422	0	TCR	27,30	CD8	56,59	TCR	CD8	6962	925	Gene	Gene	xenoreactive|dobj|START_ENTITY xenoreactive|parataxis|recruits recruits|dobj|END_ENTITY	High affinity xenoreactive TCR : MHC interaction recruits CD8 in absence of binding to MHC .
15134773	0	TCR	67,70	CD8	4,7	TCR	CD8	6962	925	Gene	Gene	CD8alphabeta|compound|START_ENTITY homologue|nmod|CD8alphabeta homologue|nsubj|CD8alphaalpha CD8alphaalpha|compound|END_ENTITY	The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR co-receptor CD8alphabeta .
15517612	0	TCR	110,113	CD8	105,108	TCR	CD8	6962	925	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
16163672	0	TCR	130,133	CD8	14,17	TCR	CD8	6962	925	Gene	Gene	using|dobj|START_ENTITY clone|advcl|using clone|nsubj|Assessment Assessment|nmod|involvement involvement|nummod|END_ENTITY	Assessment of CD8 involvement in T cell clone avidity by direct measurement of HLA-A2 / Mage3 complex density using a high-affinity TCR like monoclonal antibody .
16188324	0	TCR	92,95	CD8	122,125	TCR	CD8	6962	925	Gene	Gene	present|dobj|START_ENTITY present|advcl|cognate cognate|dobj|cells cells|compound|END_ENTITY	Idiotypic T cells specific for Morbillivirus nucleocapsid protein process and present their TCR to cognate anti-idiotypic CD8 + T cells .
16210607	0	TCR	40,43	CD8	64,67	TCR	CD8	6962	925	Gene	Gene	engagement|compound|START_ENTITY engagement|nmod|cells cells|compound|END_ENTITY	Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells .
16322475	0	TCR	105,108	CD8	38,41	TCR	CD8	6962	925	Gene	Gene	repertoire|compound|START_ENTITY flexibility|nmod|repertoire demonstrate|dobj|flexibility clonotypes|xcomp|demonstrate clonotypes|nsubj|Fluctuations Fluctuations|nmod|T-cell T-cell|compound|END_ENTITY	Fluctuations of functionally distinct CD8 + T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire .
16385630	0	TCR	130,133	CD8	106,109	TCR	CD8	6962	925	Gene	Gene	triggering|compound|START_ENTITY induced|nmod|triggering proliferation|acl|induced proliferation|nmod|cells cells|compound|END_ENTITY	Differential effects of the tryptophan metabolite 3-hydroxyanthranilic_acid on the proliferation of human CD8 + T cells induced by TCR triggering or homeostatic cytokines .
16720899	0	TCR	92,95	CD8	144,147	TCR	CD8	328483(Tax:10090)	925	Gene	Gene	delivering|dobj|START_ENTITY cells|acl|delivering Redirection|nmod|cells governed|nsubjpass|Redirection governed|nmod|coreceptor coreceptor|compound|END_ENTITY	Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression .
16769997	0	TCR	57,60	CD8	29,32	TCR	CD8	6962	925	Gene	Gene	promiscuity|compound|START_ENTITY regulated|nmod|promiscuity regulated|nsubjpass|size size|nmod|cells cells|compound|END_ENTITY	The clone size of peripheral CD8 T cells is regulated by TCR promiscuity .
1690353	0	TCR	39,42	CD8	61,64	TCR	CD8	6962	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Novel post-translational regulation of TCR expression in CD4 + CD8 + thymocytes influenced by CD4 .
18025165	0	TCR	32,35	CD8	89,92	TCR	CD8	6962	925	Gene	Gene	down-regulation|compound|START_ENTITY regulates|dobj|down-regulation regulates|nmod|cells cells|compound|END_ENTITY	Cbl-b regulates antigen-induced TCR down-regulation and IFN-gamma production by effector CD8 T cells without affecting functional avidity .
20139278	0	TCR	7,10	CD8	56,59	TCR	CD8	6962	925	Gene	Gene	use|nsubj|START_ENTITY use|nmod|CTLs CTLs|compound|END_ENTITY	Public TCR use by herpes_simplex_virus-2-specific human CD8 CTLs .
21677135	0	TCR	80,83	CD8	32,35	TCR	CD8	6962	925	Gene	Gene	engagement|compound|START_ENTITY absence|nmod|engagement function|nmod|absence function|compound|END_ENTITY	Anti-CD8 antibodies can trigger CD8 + T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining .
21738624	0	TCR	76,79	CD8	42,45	TCR	CD8	6962	925	Gene	Gene	repertoire|compound|START_ENTITY cells|nmod|repertoire cells|compound|END_ENTITY	The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotype .
23267020	0	TCR	5,8	CD8	0,3	TCR	CD8	6962	925	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	CD8 + TCR repertoire formation is guided primarily by the peptide component of the antigenic complex .
23791878	0	TCR	110,113	CD8	69,72	TCR	CD8	6962	925	Gene	Gene	transfer|compound|START_ENTITY modified|nmod|transfer cells|acl|modified possess|nsubj|cells END_ENTITY|acl:relcl|possess	Human effector T cells derived from central memory cells rather than CD8 -LRB- + -RRB- T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy .
24552712	0	TCR	93,96	CD8	120,123	TCR	CD8	6962	925	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression downregulation|nmod|T T|compound|END_ENTITY	Myeloid-derived suppressor cells are associated with viral persistence and downregulation of TCR chain expression on CD8 -LRB- + -RRB- T cells in chronic hepatitis_C patients .
25103993	0	TCR	30,33	CD8	115,118	TCR	CD8	6962	925	Gene	Gene	repertoires|compound|START_ENTITY sequencing|nmod|repertoires reveals|nsubj|sequencing reveals|dobj|enrichment enrichment|nmod|T T|compound|END_ENTITY	High-throughput sequencing of TCR repertoires in multiple_sclerosis reveals intrathecal enrichment of EBV-reactive CD8 -LRB- + -RRB- T cells .
25419629	0	TCR	4,7	CD8	72,75	TCR	CD8	6962	925	Gene	Gene	sensitivity|nmod:poss|START_ENTITY dictates|nsubj|sensitivity dictates|dobj|ability ability|nmod|T T|compound|END_ENTITY	The TCR 's sensitivity to self peptide-MHC dictates the ability of naive CD8 -LRB- + -RRB- T cells to respond to foreign antigens .
25427562	0	TCR	15,18	CD8	59,62	TCR	CD8	6962	925	Gene	Gene	triggered|nsubjpass|START_ENTITY triggered|nmod|Lck Lck|acl|associated associated|nmod|coreceptor coreceptor|compound|END_ENTITY	Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor .
25801351	0	TCR	50,53	CD8	6,9	TCR	CD8	6962	925	Gene	Gene	repertoires|compound|START_ENTITY display|dobj|repertoires display|nsubj|precursors precursors|compound|T-cell T-cell|compound|END_ENTITY	Naive CD8 -LRB- + -RRB- T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics .
25911754	0	TCR	5,8	CD8	0,3	TCR	CD8	6962	925	Gene	Gene	Bias|compound|START_ENTITY +|dobj|Bias +|nsubj|END_ENTITY	CD8 + TCR Bias and Immunodominance in HIV-1_Infection .
25945999	0	TCR	84,87	CD8	24,27	TCR	CD8	328483(Tax:10090)	925	Gene	Gene	Selection|compound|START_ENTITY Because|nmod|Selection Arise|nmod|Because T|dobj|Arise T|nsubj|+ +|compound|END_ENTITY	Human and Murine Clonal CD8 + T Cell Expansions Arise during Tuberculosis Because of TCR Selection .
25945999	0	TCR	84,87	CD8	24,27	TCR	CD8	328483(Tax:10090)	925	Gene	Gene	Selection|compound|START_ENTITY Because|nmod|Selection Arise|nmod|Because T|dobj|Arise T|nsubj|+ +|compound|END_ENTITY	Human and Murine Clonal CD8 + T Cell Expansions Arise during Tuberculosis Because of TCR Selection .
7768542	0	TCR	37,40	CD8	32,35	TCR	CD8	6962	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Spontaneous generation of human CD8 + TCR alpha beta + cells derived from precursors within the double negative compartment .
7901153	0	TCR	65,68	CD8	97,100	TCR	CD8	6962	925	Gene	Gene	T-cell_antigen_receptor|appos|START_ENTITY comodulated|nmod|T-cell_antigen_receptor comodulated|nmod|activation activation|nmod|line line|compound|END_ENTITY	CD4 but not CD8 is comodulated with the T-cell_antigen_receptor -LRB- TCR -RRB- after activation of a CD4 + CD8 + human leukemia line with staphylococcal enterotoxin .
9596673	0	TCR	49,52	CD8	69,72	TCR	CD8	6962	925	Gene	Gene	thymocytes|compound|START_ENTITY thymocytes|compound|END_ENTITY	Viral superantigen-induced negative selection of TCR transgenic CD4 + CD8 + thymocytes depends on activation , but not proliferation .
23957960	0	TCR	95,98	CD90	87,91	TCR	CD90	328483(Tax:10090)	21838(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells .
15517612	0	TCR	110,113	CD94	11,15	TCR	CD94	6962	3824	Gene	Gene	lymphocytes|compound|START_ENTITY subsets|nmod|lymphocytes expressed|nmod|subsets END_ENTITY|parataxis|expressed	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
15517612	0	TCR	110,113	CD94	37,41	TCR	CD94	6962	3824	Gene	Gene	lymphocytes|compound|START_ENTITY subsets|nmod|lymphocytes expressed|nmod|subsets CD94|parataxis|expressed CD94|dep|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
8892096	0	TCR	94,97	CDR2	105,109	TCR	CDR2	6962	1039	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	MHC-restriction , cytokine profile , and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides : comparison with myelin_basic_protein-specific T cells .
9172452	0	TCR	100,103	CSK	0,3	TCR	CSK	6962	1445	Gene	Gene	signaling|compound|START_ENTITY turning|dobj|signaling mechanism|acl|turning associates|dep|mechanism associates|compound|END_ENTITY	CSK associates with the TCR zeta and epsilon chains via its SH2 domain ; a mechanism for turning off TCR signaling .
9172452	0	TCR	24,27	CSK	0,3	TCR	CSK	6962	1445	Gene	Gene	zeta|compound|START_ENTITY associates|nmod|zeta associates|compound|END_ENTITY	CSK associates with the TCR zeta and epsilon chains via its SH2 domain ; a mechanism for turning off TCR signaling .
24100586	0	TCR	49,52	Csk	77,80	TCR	Csk	328483(Tax:10090)	12988(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45 .
24317039	0	TCR	112,115	Csk	25,28	TCR	Csk	328483(Tax:10090)	12988(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY initiation|nmod|signaling reveals|nmod|initiation reveals|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling .
16547257	0	TCR	73,76	Fyn	8,11	TCR	Fyn	328483(Tax:10090)	14360(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR .
7722293	0	TCR	138,141	Fyn	53,56	TCR	Fyn	328483(Tax:10090)	14360(Tax:10090)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1 .
21887788	0	TCR	22,25	IL-33	0,5	TCR	IL-33	328483(Tax:10090)	77125(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8 + T cells .
11807773	0	TCR	129,132	IL-4	155,159	TCR	IL-4	328483(Tax:10090)	16189(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	IL-15 induces type 1 and type 2 CD4 + and CD8 + T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro .
16818755	0	TCR	32,35	IL-4	117,121	TCR	IL-4	6962	3565	Gene	Gene	transfer|compound|START_ENTITY improve|dobj|transfer coreceptor|acl|improve coreceptor|dep|down-regulation down-regulation|nmod|production production|nmod|END_ENTITY	CD8_alpha coreceptor to improve TCR gene transfer to treat melanoma : down-regulation of tumor-specific production of IL-4 , IL-5 , and IL-10 .
9886391	0	TCR	74,77	IL-4	0,4	TCR	IL-4	328483(Tax:10090)	16189(Tax:10090)	Gene	Gene	engagement|compound|START_ENTITY absence|nmod|engagement cells|nmod|absence expression|nmod|cells enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-4 enhances IL-10 gene expression in murine Th2 cells in the absence of TCR engagement .
15517612	0	TCR	110,113	NKG2A	42,47	TCR	NKG2A	6962	3821	Gene	Gene	lymphocytes|compound|START_ENTITY subsets|nmod|lymphocytes expressed|nmod|subsets expressed|nsubjpass|receptors receptors|compound|END_ENTITY	Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8 + TCR alphabeta lymphocytes .
25825439	0	TCR	46,49	SNX17	0,5	TCR	SNX17	6962	9784	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	SNX17 Affects T Cell Activation by Regulating TCR and Integrin Recycling .
16257509	0	TCR	19,22	Shc	12,15	TCR	Shc	6962	6464	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Lck couples Shc to TCR signaling .
11157474	0	TCR	194,197	T-cell_receptor	177,192	TCR	T-cell receptor	6962	6962	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Interferon-inducible_protein_10 , monokine_induced_by_interferon_gamma , and interferon-inducible_T-cell_alpha_chemoattractant are produced by thymic epithelial cells and attract T-cell_receptor -LRB- TCR -RRB- alphabeta + CD8 + single-positive T cells , TCRgammadelta + T cells , and natural killer-type cells in human thymus .
17722993	0	TCR	39,42	T-cell_receptor	22,37	TCR	T-cell receptor	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Prolonged increase in T-cell_receptor -LRB- TCR -RRB- variant fractions of spleen T lymphocytes in pregnant mice after gamma irradiation .
17965552	0	TCR	52,55	T-cell_receptor	35,50	TCR	T-cell receptor	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Measurement of mutant_frequency in T-cell_receptor -LRB- TCR -RRB- gene by flow cytometry after X-irradiation on EL-4 mice lymphoma cells .
8320135	0	TCR	51,54	T-cell_receptor	34,49	TCR	T-cell receptor	6962	6962	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	A single universal primer for the T-cell_receptor -LRB- TCR -RRB- variable genes enables enzymatic amplification and direct sequencing of TCR beta cDNA of various T-cell clones .
21315043	0	TCR	1,4	TCR	26,29	TCR	TCR	6962	6962	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- TCR gene expression in TCR gene-modified T cells specific for DLBCL-associated antigen -RSB- .
21315043	0	TCR	26,29	TCR	1,4	TCR	TCR	6962	6962	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	-LSB- TCR gene expression in TCR gene-modified T cells specific for DLBCL-associated antigen -RSB- .
10318825	0	TCR	45,48	T_cell_antigen_receptor	20,43	TCR	T cell antigen receptor	6962	6962	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Modification of the T_cell_antigen_receptor -LRB- TCR -RRB- complex by UDP-glucose : glycoprotein glucosyltransferase .
10723795	0	TCR	52,55	T_cell_antigen_receptor	27,50	TCR	T cell antigen receptor	6962	6962	Gene	Gene	signalling|appos|START_ENTITY signalling|compound|END_ENTITY	The role of lipid rafts in T_cell_antigen_receptor -LRB- TCR -RRB- signalling .
8046335	0	TCR	46,49	T_cell_antigen_receptor	21,44	TCR	T cell antigen receptor	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Stoichiometry of the T_cell_antigen_receptor -LRB- TCR -RRB- complex : each TCR/CD3 complex contains one TCR_alpha , one TCR_beta , and two CD3_epsilon chains .
12499424	0	TCR	46,49	T_cell_receptor	29,44	TCR	T cell receptor	6962	6962	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Diagnostic role of tests for T_cell_receptor -LRB- TCR -RRB- genes .
15950730	0	TCR	63,66	caspase-3	27,36	TCR	caspase-3	6962	836	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Selective up-regulation of caspase-3 gene expression following TCR engagement .
23057733	0	TCR	12,15	interleukin-2	27,40	TCR	interleukin-2	6962	3558	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Upregulated TCR enhances interleukin-2 production in T-cells from patients with CML .
7547689	0	TCR	45,48	p56lck	28,34	TCR	p56lck	328483(Tax:10090)	16818(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	The protein tyrosine kinase p56lck regulates TCR expression and T cell selection .
7528767	0	TCR-alpha	123,132	CD4	78,81	TCR-alpha	CD4	28755	920	Gene	Gene	protein|amod|START_ENTITY synthesis|nmod|protein response|nsubj|synthesis induced|parataxis|response induced|nmod|receptor receptor|acl|signaling signaling|nmod|thymocytes thymocytes|compound|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
7528767	0	TCR-alpha	200,209	CD4	78,81	TCR-alpha	CD4	28755	920	Gene	Gene	instability|amod|START_ENTITY compensates|nmod|instability signaling|acl:relcl|compensates response|nmod|signaling induced|parataxis|response induced|nmod|receptor receptor|acl|signaling signaling|nmod|thymocytes thymocytes|compound|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
8617956	0	TCR-alpha	97,106	CD4	92,95	TCR-alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Salmonella_typhimurium aroA - infection in gene-targeted immunodeficient mice : major role of CD4 + TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location .
8871636	0	TCR-alpha	130,139	CD4	118,121	TCR-alpha	CD4	290071(Tax:10116)	24932(Tax:10116)	Gene	Gene	beta|amod|START_ENTITY Involvement|dep|beta Involvement|nmod|cytotoxicity cytotoxicity|nmod|CD8 CD8|dep|END_ENTITY	Involvement of peptide antigens in the cytotoxicity between 70-kDa_heat_shock_cognate_protein-like_molecule and CD3 + , CD4 - , CD8 - , TCR-alpha beta - killer T cells .
9413259	0	TCR-alpha	11,20	CD4	113,116	TCR-alpha	CD4	28755	920	Gene	Gene	beta|compound|START_ENTITY modulate|nsubj|beta modulate|ccomp|autoreactive autoreactive|dobj|T-cells T-cells|compound|END_ENTITY	Human CD8 + TCR-alpha beta -LRB- + -RRB- and TCR-gamma delta -LRB- + -RRB- cells modulate autologous autoreactive neuroantigen-specific CD4 + T-cells by different mechanisms .
7528767	0	TCR-alpha	123,132	CD8	83,86	TCR-alpha	CD8	28755	925	Gene	Gene	protein|amod|START_ENTITY synthesis|nmod|protein response|nsubj|synthesis induced|parataxis|response induced|nmod|receptor receptor|acl|signaling signaling|nmod|thymocytes thymocytes|compound|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
7528767	0	TCR-alpha	200,209	CD8	83,86	TCR-alpha	CD8	28755	925	Gene	Gene	instability|amod|START_ENTITY compensates|nmod|instability signaling|acl:relcl|compensates response|nmod|signaling induced|parataxis|response induced|nmod|receptor receptor|acl|signaling signaling|nmod|thymocytes thymocytes|compound|END_ENTITY	Early molecular events induced by T cell receptor -LRB- TCR -RRB- signaling in immature CD4 + CD8 + thymocytes : increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability , improves TCR assembly , and parallels other indicators of positive selection .
10464179	0	TCR_alpha	25,34	CD4	7,10	TCR alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	class|compound|START_ENTITY cells|nmod|class T|dobj|cells T|nsubj|END_ENTITY	Unique CD4 -LRB- + -RRB- T cells in TCR_alpha chain-deficient class I MHC-restricted TCR transgenic_mice : role in a superantigen-mediated disease process .
24886643	0	TCR_alpha	10,19	CD4	49,52	TCR alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	CDR3|compound|START_ENTITY favors|nsubj|CDR3 favors|dobj|profile profile|compound|END_ENTITY	Elongated TCR_alpha chain CDR3 favors an altered CD4 cytokine profile .
9137250	0	TCR_alpha	10,19	CD4	0,3	TCR alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	CD8|dep|START_ENTITY CD8|nummod|END_ENTITY	CD4 - CD8 - TCR_alpha / beta + suppressor T cells demonstrated in mice 1 day after thermal_injury .
9541577	0	TCR_alpha	2,11	CD4	50,53	TCR alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	transgene|compound|START_ENTITY induces|nsubj|transgene induces|dobj|maturation maturation|nmod|END_ENTITY	A TCR_alpha chain transgene induces maturation of CD4 - CD8 - alpha beta + T cells from gamma delta T cell precursors .
9725264	0	TCR_alpha	18,27	CD4	33,36	TCR alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Mature mainstream TCR_alpha beta + CD4 + thymocytes expressing L-selectin mediate `` active tolerance '' in the nonobese diabetic mouse .
9725264	0	TCR_alpha	18,27	L-selectin	60,70	TCR alpha	L-selectin	21473(Tax:10090)	20343(Tax:10090)	Gene	Gene	+|compound|START_ENTITY thymocytes|nsubj|+ thymocytes|xcomp|expressing expressing|dobj|tolerance tolerance|amod|END_ENTITY	Mature mainstream TCR_alpha beta + CD4 + thymocytes expressing L-selectin mediate `` active tolerance '' in the nonobese diabetic mouse .
20380794	0	TCR_beta	28,36	CD8	40,43	TCR beta	CD8	21577(Tax:10090)	925	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	-LSB- Characteristics of CDR3 of TCR_beta on CD8 + T cells in chronic_hepatitis_B patients -RSB- .
22516263	0	TCRa	113,117	ETS1	89,93	TCRa	ETS1	28755	2113	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	TLX homeodomain oncogenes mediate T cell maturation arrest in T-ALL via interaction with ETS1 and suppression of TCRa gene expression .
9119228	0	TCRalpha	73,81	ALY	0,3	TCRalpha	ALY	28755	10189	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|END_ENTITY	ALY , a context-dependent coactivator of LEF-1 and AML-1 , is required for TCRalpha enhancer function .
12393564	0	TCRalpha	99,107	CD8alpha	79,87	TCRalpha	CD8alpha	28755	925	Gene	Gene	cells|compound|START_ENTITY +|dobj|cells +|nsubj|END_ENTITY	CD8alpha alpha memory effector T cells descend directly from clonally expanded CD8alpha + beta high TCRalpha beta T cells in vivo .
24352200	0	TCTP	0,4	ATM	24,27	TCTP	ATM	41341(Tax:7227)	41839(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila_melanogaster .
15006423	0	TCTP	105,109	translationally_controlled_tumor_protein	63,103	TCTP	translationally controlled tumor protein	7178	7178	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning and expression of a mammalian homologue of a translationally_controlled_tumor_protein -LRB- TCTP -RRB- gene from Penaeus_monodon shrimp .
17894822	0	TCTP	55,59	translationally_controlled_tumor_protein	13,53	TCTP	translationally controlled tumor protein	7178	7178	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of translationally_controlled_tumor_protein -LRB- TCTP -RRB- by transcriptional and post-transcriptional mechanisms .
18630514	0	TCTP	70,74	translationally_controlled_tumor_protein	28,68	TCTP	translationally controlled tumor protein	116646(Tax:10116)	116646(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Messenger RNA expression of translationally_controlled_tumor_protein -LRB- TCTP -RRB- in liver regeneration and cancer .
19060111	0	TCTP	20,24	translationally_controlled_tumor_protein	30,70	TCTP	translationally controlled tumor protein	820916(Tax:3702)	820916(Tax:3702)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of TCTP , the translationally_controlled_tumor_protein , from Arabidopsis_thaliana .
21865235	0	TCTP	56,60	translationally_controlled_tumor_protein	14,54	TCTP	translationally controlled tumor protein	22070(Tax:10090)	22070(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of translationally_controlled_tumor_protein -LRB- TCTP -RRB- in the uterus of mice of early pregnancy and its possible significance during embryo implantation .
23933269	0	TCTP	137,141	translationally_controlled_tumor_protein	95,135	TCTP	translationally controlled tumor protein	7178	7178	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	cDNA cloning , genomic organization and expression analysis during somatic embryogenesis of the translationally_controlled_tumor_protein -LRB- TCTP -RRB- gene from Japanese larch -LRB- Larix leptolepis -RRB- .
24623877	0	TCTP	56,60	translationally_controlled_tumor_protein	14,54	TCTP	translationally controlled tumor protein	7178	7178	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of translationally_controlled_tumor_protein -LRB- TCTP -RRB- gene of Dirofilaria_immitis guided by transcriptomic screening .
22958125	0	TDAG51	35,41	PHLDA1	27,33	TDAG51	PHLDA1	22822	22822	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of PHLDA1 -LRB- TDAG51 -RRB- in basal_cell_carcinoma and trichoepithelioma .
15002043	0	TDAG51	47,53	T-cell_death-associated_gene_51	14,45	TDAG51	T-cell death-associated gene 51	22822	22822	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Regulation of T-cell_death-associated_gene_51 -LRB- TDAG51 -RRB- expression in human T-cells .
19501050	0	TDAG8	52,57	T_cell_death-associated_gene_8	20,50	TDAG8	T cell death-associated gene 8	299242(Tax:10116)	299242(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Acid-sensing by the T_cell_death-associated_gene_8 -LRB- TDAG8 -RRB- receptor cloned from rat brain .
24152439	0	TDAG8	127,132	c-Myc	19,24	TDAG8	c-Myc	8477	4609	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Acidosis decreases c-Myc oncogene expression in human lymphoma cells : a role for the proton-sensing G protein-coupled receptor TDAG8 .
25284309	0	TDF1	42,46	DYT1	0,4	TDF1	DYT1	822477(Tax:3702)	827883(Tax:3702)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	DYT1 directly regulates the expression of TDF1 for tapetum development and pollen wall formation in Arabidopsis .
25845601	0	TDG	43,46	Gadd45a	0,7	TDG	Gadd45a	6996	1647	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Gadd45a promotes DNA demethylation through TDG .
15569683	0	TDG	64,67	SUMO-1	12,18	TDG	SUMO-1	6996	7341	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Noncovalent SUMO-1 binding activity of thymine_DNA_glycosylase -LRB- TDG -RRB- is required for its SUMO-1 modification and colocalization with the promyelocytic_leukemia_protein .
23165212	0	TDG	55,58	p53	92,95	TDG	p53	6996	7157	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of thymine_DNA_glycosylase -LRB- TDG -RRB- by the tumor suppressor protein p53 .
10360221	0	TDG	49,52	thymine-DNA_glycosylase	24,47	TDG	thymine-DNA glycosylase	6996	6996	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic analysis of the thymine-DNA_glycosylase -LRB- TDG -RRB- gene on 12q22-q24 .1 in human pancreatic_ductal_adenocarcinoma .
23165212	0	TDG	55,58	thymine_DNA_glycosylase	30,53	TDG	thymine DNA glycosylase	6996	6996	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of thymine_DNA_glycosylase -LRB- TDG -RRB- by the tumor suppressor protein p53 .
1789010	0	TDH2	0,4	MET3	18,22	TDH2	MET3	853465(Tax:4932)	853466(Tax:4932)	Gene	Gene	linked|nsubjpass|START_ENTITY linked|nmod|END_ENTITY	TDH2 is linked to MET3 on chromosome X of Saccharomyces_cerevisiae .
20933032	0	TDP-43	0,6	CuZn_superoxide_dismutase	77,102	TDP-43	CuZn superoxide dismutase	23435	6647	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TDP-43 physically interacts with amyotrophic_lateral_sclerosis-linked mutant CuZn_superoxide_dismutase .
25239623	0	TDP-43	67,73	Hu_Antigen_R	0,12	TDP-43	Hu Antigen R	23435	1994	Gene	Gene	Regulator|nmod|START_ENTITY Regulator|nsubj|END_ENTITY	Hu_Antigen_R -LRB- HuR -RRB- is a Positive Regulator of RNA Binding Proteins TDP-43 and FUS/TLS : Implications for Amyotrophic Lateral_Sclerosis .
22860700	0	TDP-43	42,48	Optineurin	0,10	TDP-43	Optineurin	23435	10133	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Optineurin is potentially associated with TDP-43 and involved in the pathogenesis of inclusion body myositis .
25127017	0	TDP-43	86,92	TAR_DNA_binding_protein_43	58,84	TDP-43	TAR DNA binding protein 43	23435	23435	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	HIV-1 replication in human immune cells is independent of TAR_DNA_binding_protein_43 -LRB- TDP-43 -RRB- expression .
26108367	0	TDP-43	16,22	TDP-43	53,59	TDP-43	TDP-43	23435	23435	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|END_ENTITY	Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron_degeneration with pathological features of ALS .
26108367	0	TDP-43	53,59	TDP-43	16,22	TDP-43	TDP-43	23435	23435	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	Wild type human TDP-43 potentiates ALS-linked mutant TDP-43 driven progressive motor and cortical neuron_degeneration with pathological features of ALS .
23541532	0	TDP-43	74,80	Ubiquilin-2	0,11	TDP-43	Ubiquilin-2	23435	29978	Gene	Gene	region|nmod|START_ENTITY binds|nmod|region binds|nsubj|END_ENTITY	Ubiquilin-2 -LRB- UBQLN2 -RRB- binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells : characterization of inhibition by nucleic acids and 4-aminoquinolines .
19285963	0	TDP-43	59,65	casein_kinase-1	18,33	TDP-43	casein kinase-1	23435	122011	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|sites sites|amod|END_ENTITY	Identification of casein_kinase-1 phosphorylation sites on TDP-43 .
24105464	0	TDP-43	0,6	casein_kinase_I	26,41	TDP-43	casein kinase I	37781(Tax:7227)	32221(Tax:7227)	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	TDP-43 Phosphorylation by casein_kinase_I promotes oligomerization and enhances toxicity in vivo .
22659571	0	TDP-43	96,102	caspase-7	65,74	TDP-43	caspase-7	23435	840	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function .
22584570	0	TDP-43	29,35	fragile_X_mental_retardation_protein	51,87	TDP-43	fragile X mental retardation protein	23435	2332	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Neurodegeneration-associated TDP-43 interacts with fragile_X_mental_retardation_protein -LRB- FMRP -RRB- / Staufen -LRB- STAU1 -RRB- and regulates SIRT1 expression in neuronal cells .
24355542	0	TDP1	72,76	tyrosyl-DNA-phosphodiesterase_1	39,70	TDP1	tyrosyl-DNA-phosphodiesterase 1	55775	55775	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase_1 -LRB- TDP1 -RRB- in human lung_cancer cells from the NCI-60 panel .
21041670	0	TDP1	39,43	tyrosyl-DNA_phosphodiesterase	8,37	TDP1	tyrosyl-DNA phosphodiesterase	55775	55775	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of tyrosyl-DNA_phosphodiesterase -LRB- TDP1 -RRB- in mitochondria .
24637157	0	TDP1	118,122	tyrosyl-DNA_phosphodiesterase_1	85,116	TDP1	tyrosyl-DNA phosphodiesterase 1	55775	55775	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA_phosphodiesterase_1 -LRB- TDP1 -RRB- inhibitors .
26265046	0	TDP43	35,40	MALAT1	14,20	TDP43	MALAT1	23435	378938	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung_cancer cells in vitro .
25749352	0	TDRG1	68,73	Testis_Developmental_Related_Gene_1	31,66	TDRG1	Testis Developmental Related Gene 1	732253	732253	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and Localization of Testis_Developmental_Related_Gene_1 -LRB- TDRG1 -RRB- in Human Spermatozoa .
11459831	0	TDT	19,22	CD8	46,49	TDT	CD8	1791	925	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Down-regulation of TDT transcription in CD4 -LRB- + -RRB- CD8 -LRB- + -RRB- thymocytes by Ikaros proteins in direct competition with an Ets activator .
18775765	0	TEAD1	0,5	prolactin	15,24	TEAD1	prolactin	7003	5617	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells .
22775265	0	TEAD3	42,47	TEF-5	49,54	TEAD3	TEF-5	7005	7005	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the porcine TEAD3 -LRB- TEF-5 -RRB- gene : examination of a promoter mutation as the causal mutation of a quantitative trait loci affecting the androstenone level in boar fat .
21701496	0	TEAD4	21,26	myogenin	51,59	TEAD4	myogenin	21679(Tax:10090)	17928(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation .
12442331	0	TECK	22,26	CCL25	15,20	TECK	CCL25	20300(Tax:10090)	20300(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CCL25 -LRB- TECK -RRB- in the generation of the murine small-intestinal CD8alpha alpha + CD3 + intraepithelial lymphocyte compartment .
10498628	0	TECK	0,4	CCR9	72,76	TECK	CCR9	6370	10803	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	TECK , an efficacious chemoattractant for human thymocytes , uses GPR-9-6 / CCR9 as a specific receptor .
26431026	0	TECPR2	0,6	LC3C	23,27	TECPR2	LC3C	9895	440738	Gene	Gene	Cooperates|compound|START_ENTITY Cooperates|nmod|END_ENTITY	TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export .
9503015	0	TECTA	36,41	alpha-tectorin	15,29	TECTA	alpha-tectorin	21683(Tax:10090)	21683(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the alpha-tectorin gene -LRB- TECTA -RRB- to mouse chromosome 9 and human chromosome 11 : a candidate for human autosomal_dominant_nonsyndromic_deafness .
22775265	0	TEF-5	49,54	TEAD3	42,47	TEF-5	TEAD3	7005	7005	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular characterization of the porcine TEAD3 -LRB- TEF-5 -RRB- gene : examination of a promoter mutation as the causal mutation of a quantitative trait loci affecting the androstenone level in boar fat .
15963946	0	TEIF	55,59	DNA_polymerase_beta	32,51	TEIF	DNA polymerase beta	57410	5423	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of DNA_polymerase_beta by TEIF .
11755466	0	TEK	46,49	angiopoietin-1	14,28	TEK	angiopoietin-1	7010	284	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of angiopoietin-1 and its receptor TEK in hematopoietic cells from patients with myeloid_leukemia .
11157492	0	TEL	27,30	ETV6	32,36	TEL	ETV6	2120	2120	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Breakage and fusion of the TEL -LRB- ETV6 -RRB- gene in immature B lymphocytes induced by apoptogenic signals .
16737910	0	TEL	62,65	ETV6	56,60	TEL	ETV6	2120	2120	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Identification of the nuclear localization motif in the ETV6 -LRB- TEL -RRB- protein .
8695816	0	TEL	117,120	ETV6	127,131	TEL	ETV6	2120	2120	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fluorescence in situ hybridization analysis of t -LRB- 3 ; 12 -RRB- -LRB- q26 ; p13 -RRB- : a recurring chromosomal_abnormality involving the TEL gene -LRB- ETV6 -RRB- in myelodysplastic_syndromes .
9204978	0	TEL	14,17	ETV6	8,12	TEL	ETV6	2120	2120	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of ETV6 -LRB- TEL -RRB- gene rearrangements or p16INK4A/p15INK4B homozygous gene deletions in infant acute_lymphoblastic_leukemia .
9523197	0	TEL	77,80	ETV6	71,75	TEL	ETV6	2120	2120	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of new partner chromosomes involved in fusions with the ETV6 -LRB- TEL -RRB- gene in hematologic_malignancies .
9891517	0	TEL	23,26	VEGF	68,72	TEL	VEGF	2120	7422	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The ETS-related factor TEL is regulated by angiogenic growth factor VEGF in HUVE-cells .
7545545	0	TEL1	0,4	MEC1	136,140	TEL1	MEC1	852190(Tax:4932)	852433(Tax:4932)	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	TEL1 , an S. _ cerevisiae homolog of the human gene mutated in ataxia_telangiectasia , is functionally related to the yeast checkpoint gene MEC1 .
15743832	0	TEL2	21,25	Myc	42,45	TEL2	Myc	51513	4609	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis .
17220202	0	TELOMERASE_ACTIVATOR1	70,91	BT2	43,46	TELOMERASE ACTIVATOR1	BT2	820085(Tax:3702)	823994(Tax:3702)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Regulation of telomerase in Arabidopsis by BT2 , an apparent target of TELOMERASE_ACTIVATOR1 .
3143303	0	TEM-1	154,159	PSE-1	114,119	TEM-1	PSE-1	2716540(Tax:562)	13906560	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Resistance to ticarcillin-potassium_clavulanate among clinical isolates of the family Enterobacteriaceae : role of PSE-1 beta-lactamase and high levels of TEM-1 and SHV-1 and problems with false susceptibility in disk diffusion tests .
26243615	0	TEMPRANILLO2	36,48	SHORT_VEGETATIVE_PHASE	0,22	TEMPRANILLO2	SHORT VEGETATIVE PHASE	843216(Tax:3702)	816787(Tax:3702)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	SHORT_VEGETATIVE_PHASE up-regulates TEMPRANILLO2 floral repressor at low ambient temperatures .
26243615	0	TEMPRANILLO2	36,48	SHORT_VEGETATIVE_PHASE	0,22	TEMPRANILLO2	SHORT VEGETATIVE PHASE	843216(Tax:3702)	816787(Tax:3702)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	SHORT_VEGETATIVE_PHASE up-regulates TEMPRANILLO2 floral repressor at low ambient temperatures .
23564352	0	TERE1	4,9	TBL2	47,51	TERE1	TBL2	29914	26608	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The TERE1 protein interacts with mitochondrial TBL2 : regulation of trans-membrane potential , ROS/RNS and SXR target genes .
23759948	0	TERE1	26,31	UBIAD1	33,39	TERE1	UBIAD1	29914	29914	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Ectopic expression of the TERE1 -LRB- UBIAD1 -RRB- protein inhibits growth of renal_clear_cell_carcinoma cells : altered metabolic phenotype associated with reactive oxygen species , nitric_oxide and SXR target genes involved in cholesterol and lipid metabolism .
9611176	0	TERMINAL_FLOWER2	4,20	TFL2	22,26	TERMINAL FLOWER2	TFL2	831635(Tax:3702)	831635(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The TERMINAL_FLOWER2 -LRB- TFL2 -RRB- gene controls the reproductive transition and meristem identity in Arabidopsis_thaliana .
16135795	0	TERT	80,84	AP-1	12,16	TERT	AP-1	7015	3725	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Function of AP-1 in transcription of the telomerase_reverse_transcriptase_gene -LRB- TERT -RRB- in human and mouse cells .
26953344	0	TERT	46,50	ARID1A	13,19	TERT	ARID1A	7015	8289	Gene	Gene	Transcription|compound|START_ENTITY Transcription|compound|END_ENTITY	Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells .
19936027	0	TERT	48,52	ERalpha	0,7	TERT	ERalpha	7015	2099	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	ERalpha increases expression and interacts with TERT in cataractous canine lens epithelial cells .
21300782	0	TERT	29,33	PITX1	18,23	TERT	PITX1	7015	5307	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of PITX1 as a TERT suppressor gene located on human chromosome 5 .
24816985	0	TERT	26,30	PTTG1	11,16	TERT	PTTG1	7015	9232	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells .
20127252	0	TERT	32,36	TRF1	14,18	TERT	TRF1	7015	7013	Gene	Gene	KU70|appos|START_ENTITY KU70|compound|END_ENTITY	Expression of TRF1 , TRF2 , TIN2 , TERT , KU70 , and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric_cancer .
24423165	0	TERT	64,68	Telomerase_Reverse_Transcriptase	25,57	TERT	Telomerase Reverse Transcriptase	403412(Tax:9615)	403412(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms within the Telomerase_Reverse_Transcriptase gene -LRB- TERT -RRB- in four breeds of dogs selected for difference in lifespan and cancer susceptibility .
19331168	0	TERT	34,38	Telomerase_reverse_transcriptase	0,32	TERT	Telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Telomerase_reverse_transcriptase -LRB- TERT -RRB- expression in canine mammary tissues : a specific marker for malignancy ?
11468156	0	TERT	56,60	telomerase_reverse_transcriptase	22,54	TERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transfer of the human telomerase_reverse_transcriptase -LRB- TERT -RRB- gene into T lymphocytes results in extension of replicative potential .
11859209	0	TERT	48,52	telomerase_reverse_transcriptase	14,46	TERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of telomerase_reverse_transcriptase -LRB- TERT -RRB- in malignant mesotheliomas .
12808208	0	TERT	66,70	telomerase_reverse_transcriptase	32,64	TERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of the feline telomerase_reverse_transcriptase -LRB- TERT -RRB- gene and its expression in cell lines and normal tissues .
16026073	0	TERT	67,71	telomerase_reverse_transcriptase	33,65	TERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Immunohistochemical detection of telomerase_reverse_transcriptase -LRB- TERT -RRB- protein in benign and malignant_tumor cells of the breast .
18042045	0	TERT	57,61	telomerase_reverse_transcriptase	23,55	TERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Brm transactivates the telomerase_reverse_transcriptase -LRB- TERT -RRB- gene and modulates the splicing patterns of its transcripts in concert with p54 -LRB- nrb -RRB- .
20460502	0	TERT	54,58	telomerase_reverse_transcriptase	20,52	TERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deregulation of the telomerase_reverse_transcriptase -LRB- TERT -RRB- gene by chromosomal translocations in B-cell malignancies .
20964812	0	TERT	92,96	telomerase_reverse_transcriptase	58,90	TERT	telomerase reverse transcriptase	420972(Tax:9031)	420972(Tax:9031)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Alternative splicing and nonsense-mediated_decay regulate telomerase_reverse_transcriptase -LRB- TERT -RRB- expression during virus-induced lymphomagenesis in vivo .
15817463	0	TESK1	25,30	Actopaxin	0,9	TESK1	Actopaxin	7016	55742	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin .
12027893	0	TESK1	90,95	sprouty_4	6,15	TESK1	sprouty 4	7016	81848	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human sprouty_4 , a new ras antagonist on 5q31 , interacts with the dual specificity kinase TESK1 .
9705840	0	TESK1	63,68	testis-specific_protein_kinase_1	29,61	TESK1	testis-specific protein kinase 1	29460(Tax:10116)	29460(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Stage-specific expression of testis-specific_protein_kinase_1 -LRB- TESK1 -RRB- in rat spermatogenic cells .
22948384	0	TET1	16,20	APOBEC3A	43,51	TET1	APOBEC3A	80312	200315	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients .
23328087	0	TET1	0,4	IL-1b	48,53	TET1	IL-1b	80312	3553	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	TET1 is a negative transcriptional regulator of IL-1b in the THP-1 cell line .
26776158	0	TET1	95,99	miR-29b	58,65	TET1	miR-29b	80312	407024	Gene	Gene	downregulation|nmod|START_ENTITY END_ENTITY|nmod|downregulation	Enhanced MAPK signaling drives ETS1-mediated induction of miR-29b leading to downregulation of TET1 and changes in epigenetic modifications in a subset of lung SCC .
25824049	0	TET1	98,102	ten-eleven_translocation_1	70,96	TET1	ten-eleven translocation 1	80312	80312	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven_translocation_1 -LRB- TET1 -RRB- mRNA .
24465546	0	TET2	14,18	ASXL1	0,5	TET2	ASXL1	54790	171023	Gene	Gene	mutations|nummod|START_ENTITY END_ENTITY|nmod|mutations	ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases .
23353889	0	TET2	0,4	OGT	66,69	TET2	OGT	214133(Tax:10090)	108155(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS .
25601757	0	TET2	13,17	WT1	0,3	TET2	WT1	54790	7490	Gene	Gene	START_ENTITY|nsubj|Recruits Recruits|compound|END_ENTITY	WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress_Leukemia Cell Proliferation .
19564637	0	TET2	44,48	ten-eleven_translocation_2	16,42	TET2	ten-eleven translocation 2	54790	54790	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the ten-eleven_translocation_2 -LRB- TET2 -RRB- gene in familial_myeloproliferative_neoplasms .
25843715	0	TET3	0,4	REST	21,25	TET3	REST	194388(Tax:10090)	19712(Tax:10090)	Gene	Gene	Recruited|nsubjpass|START_ENTITY Recruited|nmod|END_ENTITY	TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression .
23396665	0	TEX101	44,50	TSGA10	36,42	TEX101	TSGA10	83639	80705	Gene	Gene	Genes|nummod|START_ENTITY Genes|nummod|END_ENTITY	Expression of Testis Specific Genes TSGA10 , TEX101 and ODF3 in Breast_Cancer .
20176808	0	TEX14	0,5	CEP55	21,26	TEX14	CEP55	56155	55165	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TEX14 interacts with CEP55 to block cell abscission .
26797282	0	TFAM	69,73	PGC-1	63,68	TFAM	PGC-1	7019	10891	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1 / TFAM pathway in human umbilical vein endothelial cells -LRB- HUVECs -RRB- .
21113058	0	TFAM	36,40	Serca2	60,66	TFAM	Serca2	83474(Tax:10116)	29693(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|transcription transcription|amod|END_ENTITY	Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription .
24875355	0	TFAM	77,81	TFAM	94,98	TFAM	TFAM	7019	7019	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Negative transcriptional regulation of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- by nuclear TFAM .
24875355	0	TFAM	94,98	TFAM	77,81	TFAM	TFAM	7019	7019	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Negative transcriptional regulation of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- by nuclear TFAM .
25556274	0	TFAM	121,125	miR-214	23,30	TFAM	miR-214	7019	406996	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	The inhibitory role of miR-214 in cervical_cancer cells through directly targeting mitochondrial_transcription_factor_A -LRB- TFAM -RRB- .
24002170	0	TFAM	0,4	miR-23b	30,37	TFAM	miR-23b	7019	407011	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	TFAM is directly regulated by miR-23b in glioma .
15464268	0	TFAM	62,66	mitochondrial_transcription_factor_A	24,60	TFAM	mitochondrial transcription factor A	7019	7019	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Possible association of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- genotype with sporadic Alzheimer_disease .
15547250	0	TFAM	66,70	mitochondrial_transcription_factor_A	28,64	TFAM	mitochondrial transcription factor A	7019	7019	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Transient overexpression of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- is sufficient to stimulate mitochondrial DNA transcription , but not sufficient to increase mtDNA copy number in cultured cells .
18636550	0	TFAM	52,56	mitochondrial_transcription_factor_A	14,50	TFAM	mitochondrial transcription factor A	397279(Tax:9823)	397279(Tax:9823)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- during porcine gametogenesis and preimplantation embryo development .
24875355	0	TFAM	77,81	mitochondrial_transcription_factor_A	39,75	TFAM	mitochondrial transcription factor A	7019	7019	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Negative transcriptional regulation of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- by nuclear TFAM .
24875355	0	TFAM	94,98	mitochondrial_transcription_factor_A	39,75	TFAM	mitochondrial transcription factor A	7019	7019	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative transcriptional regulation of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- by nuclear TFAM .
18275040	0	TFAP2	64,69	TBX20	20,25	TFAP2	TBX20	7020	57057	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of TBX20 in human hearts and its regulation by TFAP2 .
24335623	0	TFAP2A	0,6	HIF-1a	75,81	TFAP2A	HIF-1a	7020	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	TFAP2A regulates nasopharyngeal_carcinoma growth and survival by targeting HIF-1a signaling pathway .
19325541	0	TFAP2B	25,31	insulin	51,58	TFAP2B	insulin	7021	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents .
26832794	0	TFAP2C	21,27	EGFR	0,4	TFAP2C	EGFR	7022	1956	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|END_ENTITY	EGFR Is Regulated by TFAP2C in Luminal Breast_Cancer and Is a Target for Vandetanib .
19458056	0	TFAP2C	15,21	estrogen_receptor-alpha	31,54	TFAP2C	estrogen receptor-alpha	7022	2099	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Interaction of TFAP2C with the estrogen_receptor-alpha promoter is controlled by chromatin structure .
16793605	0	TFAR19	15,21	PDCD5	22,27	TFAR19	PDCD5	9141	9141	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of TFAR19 -LRB- PDCD5 -RRB- in normal human kidney , renal_clear_cell_carcinoma , normal human bladder_and_bladder_carcinoma -RSB- .
16327801	0	TFE3	0,4	IRS-2	41,46	TFE3	IRS-2	209446(Tax:10090)	384783(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TFE3 transcriptionally activates hepatic IRS-2 , participates in insulin signaling and ameliorates diabetes .
11358836	0	TFE3	38,42	RCC17	24,29	TFE3	RCC17	7030	79058	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Fusion of a novel gene , RCC17 , to the TFE3 gene in t -LRB- X ; 17 -RRB- -LRB- p11 .2 ; q25 .3 -RRB- - bearing papillary_renal_cell_carcinomas .
7490085	0	TFE3	62,66	transcription_factor_3	38,60	TFE3	transcription factor 3	7030	6929	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The genomic organization of the human transcription_factor_3 -LRB- TFE3 -RRB- gene .
27001890	0	TFEB	25,29	TOR	34,37	TFEB	TOR	7942	6097	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals .
21804531	0	TFEB	14,18	mTORC1	36,42	TFEB	mTORC1	7942	382056(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of TFEB and V-ATPases by mTORC1 .
22692423	0	TFEB	25,29	mTORC1	36,42	TFEB	mTORC1	7942	382056(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis .
24770416	0	TFEB	88,92	transcription_factor_EB	63,86	TFEB	transcription factor EB	7942	7942	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	The phytoestrogen genistein modulates lysosomal metabolism and transcription_factor_EB -LRB- TFEB -RRB- activation .
26264650	0	TFEB	49,53	transcription_factor_EB	24,47	TFEB	transcription factor EB	7942	7942	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of transcription_factor_EB -LRB- TFEB -RRB- is associated with autophagy , migratory phenotype and poor prognosis in non-small cell lung_cancer .
15289936	0	TFF1	20,24	MUC5AC	37,43	TFF1	MUC5AC	7031	4586	Gene	Gene	bound|nsubjpass|START_ENTITY bound|nmod|END_ENTITY	The trefoil protein TFF1 is bound to MUC5AC in human gastric_mucosa .
25015107	0	TFF1	0,4	p53	15,18	TFF1	p53	21784(Tax:10090)	22060(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TFF1 activates p53 through down-regulation of miR-504 in gastric_cancer .
11310832	0	TFF1	60,64	pS2	55,58	TFF1	pS2	7031	7031	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Augmented intestinal_trefoil_factor -LRB- TFF3 -RRB- and loss of pS2 -LRB- TFF1 -RRB- expression precedes metaplastic differentiation of gastric epithelium .
17565651	0	TFF1	17,21	pS2	23,26	TFF1	pS2	7031	7031	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Up-regulation of TFF1 -LRB- pS2 -RRB- expression by TNF-alpha in gastric epithelial cells .
19132993	0	TFF1	5,9	pS2	0,3	TFF1	pS2	7031	7031	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	pS2 -LRB- TFF1 -RRB- expression in prostate_carcinoma : correlation with steroid receptor status .
10369712	0	TFF1	13,17	transforming_growth_factor_alpha	61,93	TFF1	transforming growth factor alpha	21784(Tax:10090)	21802(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of TFF1 gene expression in pancreas overexpressing transforming_growth_factor_alpha .
15177874	0	TFF1	57,61	trefoil_factor_family_1	32,55	TFF1	trefoil factor family 1	117270(Tax:10116)	7031	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Synergistic effects of systemic trefoil_factor_family_1 -LRB- TFF1 -RRB- peptide and epidermal_growth_factor in a rat model of colitis .
15821928	0	TFF1	45,49	trefoil_factor_family_protein_1	12,43	TFF1	trefoil factor family protein 1	7031	7031	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of trefoil_factor_family_protein_1 -LRB- TFF1 , pS2 -RRB- expression in chronic cholecystitis and gallbladder_carcinoma .
17332476	0	TFF2	22,26	Gastrin	0,7	TFF2	Gastrin	21785(Tax:10090)	14459(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY regulates|dobj|promoter regulates|nsubj|END_ENTITY	Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways .
9858857	0	TFF2	25,29	Spasmolysin	31,42	TFF2	Spasmolysin	7032	7032	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Variable distribution of TFF2 -LRB- Spasmolysin -RRB- alleles in Europeans does not indicate predisposition to gastric_cancer .
12054609	0	TFF2	39,43	trefoil_factor_2	21,37	TFF2	trefoil factor 2	7032	7032	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Autoinduction of the trefoil_factor_2 -LRB- TFF2 -RRB- promoter requires an upstream cis-acting element .
17118693	0	TFF2	96,100	trefoil_factor_family_2	71,94	TFF2	trefoil factor family 2	7032	7032	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- regulates trefoil_factor_family_2 -LRB- TFF2 -RRB- expression in gastric epithelial cells .
17182120	0	TFF3	14,18	CDX2	53,57	TFF3	CDX2	7033	1045	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of TFF3 expression by homeodomain protein CDX2 .
15177879	0	TFF3	0,4	Fos	13,16	TFF3	Fos	25563(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TFF3 induced Fos protein expression in the magnocellular oxytocin neurons of the hypothalamus .
23570281	0	TFF3	10,14	IMP3	17,21	TFF3	IMP3	7033	55272	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	ER + / PR + / TFF3 + / IMP3 - immunoprofile distinguishes endometrioid from serous and clear_cell_carcinomas of the endometrium : a study of 401 cases .
18326859	0	TFF3	26,30	Intestinal_trefoil_factor	0,25	TFF3	Intestinal trefoil factor	21786(Tax:10090)	21786(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Intestinal_trefoil_factor / TFF3 promotes re-epithelialization of corneal wounds .
23578537	0	TFF3	25,29	Trefoil_factor_family_3	0,23	TFF3	Trefoil factor family 3	7033	7033	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Trefoil_factor_family_3 -LRB- TFF3 -RRB- expression and its interaction with estrogen_receptor -LRB- ER -RRB- in endometrial_adenocarcinoma .
16547966	0	TFG	4,7	TANK	70,74	TFG	TANK	10342	10010	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The TFG protein , involved in oncogenic rearrangements , interacts with TANK and NEMO , two proteins involved in the NF-kappaB pathway .
23810392	0	TFG	77,80	TRK-fused_gene	61,75	TFG	TRK-fused gene	10342	10342	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused_gene -LRB- TFG -RRB- protein .
8332347	0	TFG-alpha	121,130	TNF-alpha	72,81	TFG-alpha	TNF-alpha	7039	7124	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY tumor_necrosis_factor-alpha|appos|END_ENTITY	-LSB- Creation of monoclonal antibodies against tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and transforming_growth_factor_alpha -LRB- TFG-alpha -RRB- , their definition and possible use -RSB- .
23831514	0	TFII-I	0,6	PI-3K	37,42	TFII-I	PI-3K	14886(Tax:10090)	18708(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TFII-I regulates target genes in the PI-3K and TGF-b signaling pathways through a novel DNA binding motif .
12193603	0	TFII-I	114,120	Siz2	75,79	TFII-I	Siz2	2969	9063	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta / Siz2 is a transcriptional cofactor for TFII-I .
16537915	0	TFIIA	10,15	taspase_1	35,44	TFIIA	taspase 1	398704(Tax:8355)	734301(Tax:8355)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Uncleaved TFIIA is a substrate for taspase_1 and active in transcription .
9547268	0	TFIIB	115,120	MyoD	79,83	TFIIB	MyoD	2959	4654	Gene	Gene	association|nmod|START_ENTITY facilitates|dobj|association facilitates|nsubj|END_ENTITY	TFIID -LRB- TBP -RRB- stabilizes the binding of MyoD to its DNA site at the promoter and MyoD facilitates the association of TFIIB with the preinitiation complex .
18048413	0	TFIIB	20,25	NC2	41,44	TFIIB	NC2	2959	1810	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	The dual control of TFIIB recruitment by NC2 is gene specific .
7642649	0	TFIIB	26,31	Oct-1	15,20	TFIIB	Oct-1	2959	5451	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Oct-1 with TFIIB .
1909174	0	TFIID	65,70	Serum_response_factor	0,21	TFIID	Serum response factor	6908	6722	Gene	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	Serum_response_factor affects preinitiation complex formation by TFIID in vitro .
8450888	0	TFIID	51,56	p250	4,8	TFIID	p250	6908	6872	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1 .
20618999	0	TFIIF	78,83	GAS41	24,29	TFIIF	GAS41	2962	8089	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The YEATS family member GAS41 interacts with the general transcription factor TFIIF .
8758937	0	TFIIF_beta	96,106	hTAFII100	20,29	TFIIF beta	hTAFII100	2963	6877	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|domains domains|nmod|END_ENTITY	Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF_beta -LRB- RAP30 -RRB- and incorporation into the TFIID complex .
12590132	0	TFIIH	118,123	ERCC3	62,67	TFIIH	ERCC3	2071	2071	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH .
10882074	0	TFIIH	38,43	FBP_interacting_repressor	4,29	TFIIH	FBP interacting repressor	2071	22827	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The FBP_interacting_repressor targets TFIIH to inhibit activated transcription .
12376559	0	TFIIH	44,49	Mat1	28,32	TFIIH	Mat1	2965	4331	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Conditional ablation of the Mat1 subunit of TFIIH in Schwann cells provides evidence that Mat1 is not required for general transcription .
18391197	0	TFIIH	54,59	TAF7	16,20	TFIIH	TAF7	2068	6879	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb .
18630911	0	TFIIH	57,62	Tfb1	41,45	TFIIH	Tfb1	2965	2965	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	NMR structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of VP16 : structural similarities between VP16 and p53 .
19897425	0	TFIIH	52,57	Tfb2	28,32	TFIIH	Tfb2	404672	855981(Tax:4932)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Interacting partners of the Tfb2 subunit from yeast TFIIH .
17466625	0	TFIIH	15,20	XPG	0,3	TFIIH	XPG	2068	2073	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	XPG stabilizes TFIIH , allowing transactivation of nuclear receptors : implications for Cockayne_syndrome in XP-G/CS patients .
9488660	0	TFIIH	121,126	p16INK4A	34,42	TFIIH	p16INK4A	2968	1029	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH .
15890366	0	TFIIH	94,99	p44	79,82	TFIIH	p44	2966	10561	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Dynamics and metal exchange properties of C4C4 RING domains from CNOT4 and the p44 subunit of TFIIH .
9880511	0	TFIIH	68,73	p44	53,56	TFIIH	p44	2966	2966	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The hematopoietic transcription factor SCL binds the p44 subunit of TFIIH .
17339330	0	TFIIH	97,102	p52	82,85	TFIIH	p52	39202(Tax:7227)	39688(Tax:7227)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome_fragility .
12509240	0	TFIIH	63,68	p62	76,79	TFIIH	p62	39202(Tax:7227)	36598(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila_melanogaster : effects on the UV light sensitivity of a p62 mutant fly .
15533047	0	TFIIH	82,87	p62	27,30	TFIIH	p62	2965	23636	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Domain architecture of the p62 subunit from the human transcription/repair factor TFIIH deduced by limited proteolysis and mass spectrometry analysis .
15625236	0	TFIIH	7,12	p62	0,3	TFIIH	p62	2966	23636	Gene	Gene	subunit|compound|START_ENTITY END_ENTITY|appos|subunit	p62 , A TFIIH subunit , directly interacts with thyroid hormone receptor and enhances T3-mediated transcription .
10748061	0	TFIIH	0,5	retinoic_acid_receptor_gamma	25,53	TFIIH	retinoic acid receptor gamma	2966	5916	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TFIIH interacts with the retinoic_acid_receptor_gamma and phosphorylates its AF-1-activating domain through cdk7 .
23352696	0	TFIIH	103,108	xeroderma_pigmentosum_group_D	53,82	TFIIH	xeroderma pigmentosum group D	2068	2068	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	DNA quality control by a lesion sensor pocket of the xeroderma_pigmentosum_group_D helicase subunit of TFIIH .
9660958	0	TFIIIC	52,58	PC4	24,27	TFIIIC	PC4	2975	10923	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III .
20543138	0	TFIIIC	21,27	mTOR	0,4	TFIIIC	mTOR	2975	21977(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	mTOR associates with TFIIIC , is found at tRNA and 5S rRNA genes , and targets their repressor Maf1 .
9441762	0	TFIIS	46,51	TCEA2	53,58	TFIIS	TCEA2	6919	6919	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic characterization of a testis-specific TFIIS -LRB- TCEA2 -RRB- gene .
16214896	0	TFIIS	109,114	negative_elongation_factor	2,28	TFIIS	negative elongation factor	6919	26012	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	A negative_elongation_factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS .
27005522	0	TFIIS.h	0,7	p53	25,28	TFIIS.h	p53	6920	7157	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	TFIIS.h , a new target of p53 , regulates transcription efficiency of pro-apoptotic bax gene .
9611176	0	TFL2	22,26	TERMINAL_FLOWER2	4,20	TFL2	TERMINAL FLOWER2	831635(Tax:3702)	831635(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The TERMINAL_FLOWER2 -LRB- TFL2 -RRB- gene controls the reproductive transition and meristem identity in Arabidopsis_thaliana .
21868574	0	TFPI	30,34	ADTRP	14,19	TFPI	ADTRP	7035	84830	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen .
26607136	0	TFPI	63,67	Fxa	56,59	TFPI	Fxa	7035	2159	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of exosite binding modulators in the inhibition of Fxa by TFPI .
11246540	0	TFPI	33,37	Tissue_factor_pathway_inhibitor	0,31	TFPI	Tissue factor pathway inhibitor	7035	7035	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- levels in the plasma and urine of children with meningococcal_disease .
7831680	0	TFPI	22,26	thrombin	30,38	TFPI	thrombin	7035	2147	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	Inhibitory effects of TFPI on thrombin and factor_Xa generation in vitro -- modulatory action of glycosaminoglycans .
10195910	0	TFPI	54,58	tissue_factor_pathway_inhibitor	21,52	TFPI	tissue factor pathway inhibitor	7035	7035	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of the tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- gene in patients with acute_coronary_syndromes and in healthy subjects : impact of the V264M substitution on plasma levels of TFPI .
11372675	0	TFPI	65,69	tissue_factor_pathway_inhibitor	32,63	TFPI	tissue factor pathway inhibitor	7035	7035	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of total and free tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- as individual pharmacological parameters of various heparins .
12560220	0	TFPI	47,51	tissue_factor_pathway_inhibitor	14,45	TFPI	tissue factor pathway inhibitor	7035	7035	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Low levels of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- increase the risk of venous_thrombosis .
1332210	0	TFPI	43,47	tissue_factor_pathway_inhibitor	10,41	TFPI	tissue factor pathway inhibitor	7035	7035	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- in the HEPTEST assay and in an amidolytic anti factor Xa assay for LMW heparin .
1412217	0	TFPI	119,123	tissue_factor_pathway_inhibitor	16,47	TFPI	tissue factor pathway inhibitor	100009401(Tax:9986)	7035	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- from rabbit plasma and characterization of its differences from TFPI isolated from human plasma .
16581344	0	TFPI	103,107	tissue_factor_pathway_inhibitor	25,56	TFPI	tissue factor pathway inhibitor	7035	7035	Gene	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of native VLDL on tissue_factor_pathway_inhibitor in endothelial cells and interactions between TFPI and lipoprotein_lipase .
8588202	0	TFPI	47,51	tissue_factor_pathway_inhibitor	14,45	TFPI	tissue factor pathway inhibitor	7035	7035	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Low levels of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- in two out of three members of a family with thrombophilia .
9974373	0	TFPI	75,79	tissue_factor_pathway_inhibitor	42,73	TFPI	tissue factor pathway inhibitor	21788(Tax:10090)	21788(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	TFPIbeta , a second product from the mouse tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- gene .
25755719	0	TFPI-2	24,30	CD133	71,76	TFPI-2	CD133	7980	8842	Gene	Gene	expression|nmod|START_ENTITY correlated|nsubj|expression correlated|nmod|expression expression|nmod|END_ENTITY	Decreased expression of TFPI-2 correlated with increased expression of CD133 in cholangiocarcinoma .
25036127	0	TFPI-2	49,55	LSD1	108,112	TFPI-2	LSD1	7980	23028	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
25036127	0	TFPI-2	49,55	lysine-specific_demethylase_1	71,100	TFPI-2	lysine-specific demethylase 1	7980	23028	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
11448060	0	TFPI-2	43,49	tissue_factor_pathway_inhibitor-2	8,41	TFPI-2	tissue factor pathway inhibitor-2	7980	7980	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- in amelanotic_melanoma -LRB- C-32 -RRB- invasion .
11687973	0	TFPI-2	55,61	tissue_factor_pathway_inhibitor-2	20,53	TFPI-2	tissue factor pathway inhibitor-2	7980	7980	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	A novel function of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- in human glioma_invasion .
25036127	0	TFPI-2	49,55	tissue_factor_pathway_inhibitor-2	14,47	TFPI-2	tissue factor pathway inhibitor-2	7980	7980	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
15735751	0	TFPI-2	106,112	tissue_factor_pathway_inhibitor_2	71,104	TFPI-2	tissue factor pathway inhibitor 2	7980	7980	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Sequential 5-Aza_2 ' - deoxycytidine/depsipeptide FK228 treatment induces tissue_factor_pathway_inhibitor_2 -LRB- TFPI-2 -RRB- expression in cancer cells .
23494474	0	TF_II_D	56,63	Lin28B	34,40	TF II D	Lin28B	6908	389421	Gene	Gene	activating|dobj|START_ENTITY END_ENTITY|acl|activating	The oncoprotein HBXIP upregulates Lin28B via activating TF_II_D to promote proliferation of breast_cancer cells .
22293114	0	TG-interacting_factor	0,21	SOX3	43,47	TG-interacting factor	SOX3	7050	6658	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	TG-interacting_factor -LRB- TGIF -RRB- downregulates SOX3 gene expression in the NT2/D1 cell line .
25088698	0	TG-interacting_factor	8,29	Tgif	31,35	TG-interacting factor	Tgif	7050	7050	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of TG-interacting_factor -LRB- Tgif -RRB- in lipid metabolism .
21046178	0	TG2	37,40	tissue_transglutaminase	12,35	TG2	tissue transglutaminase	21817(Tax:10090)	21817(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of tissue_transglutaminase -LRB- TG2 -RRB- in regulating the tumour progression of the mouse colon_carcinoma CT26 .
20395409	0	TG2	69,72	transglutaminase_2	49,67	TG2	transglutaminase 2	7052	7052	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	A profiling platform for the characterization of transglutaminase_2 -LRB- TG2 -RRB- inhibitors .
26582240	0	TGF-Beta	4,12	CD4	23,26	TGF-Beta	CD4	7040	920	Gene	Gene	Subset|compound|START_ENTITY Subset|nmod|CD25 CD25|compound|END_ENTITY	LAP TGF-Beta Subset of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- - -RRB- Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients .
18810612	0	TGF-Beta	8,16	Foxp3	37,42	TGF-Beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Role of TGF-Beta in the induction of Foxp3 expression and T regulatory cell function .
26582240	0	TGF-Beta	4,12	LAP	0,3	TGF-Beta	LAP	7040	7040	Gene	Gene	Subset|compound|START_ENTITY Subset|compound|END_ENTITY	LAP TGF-Beta Subset of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CD127 -LRB- - -RRB- Treg Cells is Increased and Overexpresses LAP TGF-Beta in Lung Adenocarcinoma Patients .
12039975	0	TGF-Beta	34,42	Smad7	0,5	TGF-Beta	Smad7	59086(Tax:10116)	81516(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular_epithelial_cells by blocking Smad2 activation .
23684931	0	TGF-a	95,100	ADAM17	113,119	TGF-a	ADAM17	7039	6868	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Human breast_cancer-associated fibroblasts enhance cancer cell proliferation through increased TGF-a cleavage by ADAM17 .
23764046	0	TGF-a	82,87	PAR-2	10,15	TGF-a	PAR-2	7124	2150	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Activated PAR-2 regulates pancreatic_cancer progression through ILK/HIF-a-induced TGF-a expression and MEK/VEGF-A-mediated angiogenesis .
24048703	0	TGF-a	61,66	PHD4	0,4	TGF-a	PHD4	7039	54681	Gene	Gene	cells|nmod|START_ENTITY stimulates|nmod|cells stimulates|nsubj|END_ENTITY	PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-a .
12520078	0	TGF-alpha	136,145	EGF	0,3	TGF-alpha	EGF	21802(Tax:10090)	13645(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY +|dobj|mice influence|parataxis|+ influence|nsubj|END_ENTITY	EGF and TGF-alpha expression influence the developmental toxicity of TCDD : dose response and AhR phenotype in EGF , TGF-alpha , and EGF + TGF-alpha knockout mice .
12520078	0	TGF-alpha	136,145	EGF	110,113	TGF-alpha	EGF	21802(Tax:10090)	13645(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY +|dobj|mice +|nsubj|response response|nmod|END_ENTITY	EGF and TGF-alpha expression influence the developmental toxicity of TCDD : dose response and AhR phenotype in EGF , TGF-alpha , and EGF + TGF-alpha knockout mice .
16411340	0	TGF-alpha	30,39	EGF	41,44	TGF-alpha	EGF	24827(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	-LSB- Enhanced expression of EGFR , TGF-alpha , EGF in hyperplastic_parathyroid glands in established stage of renal_failure in rats -RSB- .
8263129	0	TGF-alpha	168,177	EGF	163,166	TGF-alpha	EGF	7039	1950	Gene	Gene	receptor|amod|START_ENTITY epidermal_growth_factor|dep|receptor epidermal_growth_factor|appos|END_ENTITY	Androgens regulate proliferation of human_prostate_cancer cells in culture by increasing transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- and epidermal_growth_factor -LRB- EGF -RRB- / TGF-alpha receptor .
8617990	0	TGF-alpha	82,91	EGF	130,133	TGF-alpha	EGF	7039	1950	Gene	Gene	transforming_growth_factor-alpha|appos|START_ENTITY transforming_growth_factor-alpha|appos|END_ENTITY	Enhanced modulation of keratinocyte motility by transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- relative to epidermal_growth_factor -LRB- EGF -RRB- .
8772518	0	TGF-alpha	42,51	EGF	9,12	TGF-alpha	EGF	7039	1950	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Salivary EGF regulates eosinophil-derived TGF-alpha expression in hamster oral wounds .
16003946	0	TGF-alpha	115,124	EGF-r	70,75	TGF-alpha	EGF-r	7039	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Immunohistochemical localization of epidermal_growth_factor_receptor -LRB- EGF-r -RRB- and transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- in developing human ovarian follicles .
18636433	0	TGF-alpha	0,9	Hes1	60,64	TGF-alpha	Hes1	7039	3280	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|END_ENTITY	TGF-alpha induces upregulation and nuclear translocation of Hes1 in glioma cell .
12606576	0	TGF-alpha	51,60	TACE	0,4	TGF-alpha	TACE	21802(Tax:10090)	11491(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	TACE is required for the activation of the EGFR by TGF-alpha in tumors .
7727772	0	TGF-alpha	84,93	Transforming_growth_factor-alpha	0,32	TGF-alpha	Transforming growth factor-alpha	7039	7124	Gene	Gene	demonstration|nmod|START_ENTITY END_ENTITY|dep|demonstration	Transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in human bone marrow : demonstration of TGF-alpha in erythroblasts and eosinophilic precursor cells and of epidermal_growth_factor receptors in blastlike cells of myelomonocytic origin .
8560658	0	TGF-alpha	75,84	Transforming_growth_factor-alpha	0,32	TGF-alpha	Transforming growth factor-alpha	7039	7124	Gene	Gene	expression|amod|START_ENTITY expression|dep|expression expression|amod|END_ENTITY	Transforming_growth_factor-alpha expression in human renal_cell_carcinoma : TGF-alpha expression in renal_cell_carcinoma .
9052515	0	TGF-alpha	34,43	Transforming_growth_factor-alpha	0,32	TGF-alpha	Transforming growth factor-alpha	7039	7124	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- levels in human proximal gastrointestinal epithelium .
10449674	0	TGF-alpha	34,43	Transforming_growth_factor_alpha	0,32	TGF-alpha	Transforming growth factor alpha	7039	7124	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- expression in dysplastic_oral_leukoplakia : modulation by 13-cis retinoic_acid .
8712733	0	TGF-alpha	34,43	Transforming_growth_factor_alpha	0,32	TGF-alpha	Transforming growth factor alpha	7039	7124	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- expression in biopsies of colorectal_carcinoma is a significant prognostic indicator .
1348890	0	TGF-alpha	92,101	c-erbB-2	57,65	TGF-alpha	c-erbB-2	7039	2064	Gene	Gene	EGF|dep|START_ENTITY products|appos|EGF products|dep|EGF-R EGF-R|dep|END_ENTITY	Immunohistochemical studies on oncogene products -LRB- EGF-R , c-erbB-2 -RRB- and growth factors -LRB- EGF , TGF-alpha -RRB- in human breast_cancer : their relationship to oestrogen receptor status , histological grade , mitotic index and nodal status .
16033092	0	TGF-alpha	0,9	c-erbB-2	11,19	TGF-alpha	c-erbB-2	7039	2064	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	TGF-alpha , c-erbB-2 expression and neoangiogenesis in vulvar_squamous_cell_carcinoma .
8263129	0	TGF-alpha	168,177	epidermal_growth_factor	138,161	TGF-alpha	epidermal growth factor	7039	1950	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Androgens regulate proliferation of human_prostate_cancer cells in culture by increasing transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- and epidermal_growth_factor -LRB- EGF -RRB- / TGF-alpha receptor .
8143931	0	TGF-alpha	71,80	kFGF	91,95	TGF-alpha	kFGF	7039	2249	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	All-trans-retinoic_acid and hexamethylene_bisacetamide -LRB- HMBA -RRB- regulate TGF-alpha and Hst-1 / kFGF expression in differentiation sensitive but not in resistant human teratocarcinomas .
10732760	0	TGF-alpha	63,72	transforming_growth_factor-alpha	29,61	TGF-alpha	transforming growth factor-alpha	7039	7124	Gene	Gene	perspectives|appos|START_ENTITY perspectives|nmod|END_ENTITY	Role and new perspectives of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in adenocarcinoma of the gastro-oesophageal junction .
15294092	0	TGF-alpha	45,54	transforming_growth_factor-alpha	11,43	TGF-alpha	transforming growth factor-alpha	21802(Tax:10090)	21802(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in vitro and in vivo on reovirus replication .
2064983	0	TGF-alpha	185,194	transforming_growth_factor-alpha	8,40	TGF-alpha	transforming growth factor-alpha	24827(Tax:10116)	7124	Gene	Gene	antibodies|compound|START_ENTITY using|dobj|antibodies studies|acl|using Role|dep|studies Role|nmod|END_ENTITY	Role of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in basal and hormone-stimulated growth by estradiol , prolactin and progesterone in human and rat mammary tumor cells : studies using TGF-alpha and EGF_receptor antibodies .
9765263	0	TGF-alpha	66,75	transforming_growth_factor-alpha	32,64	TGF-alpha	transforming growth factor-alpha	7039	7124	Gene	Gene	minimization|appos|START_ENTITY minimization|nmod|END_ENTITY	Structure-based minimization of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- through NMR analysis of the receptor-bound ligand .
9797711	0	TGF-alpha	49,58	transforming_growth_factor-alpha	15,47	TGF-alpha	transforming growth factor-alpha	7039	7124	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	High levels of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- mRNA may predict local relapses in early stage urinary bladder_cancer .
9850316	0	TGF-alpha	48,57	transforming_growth_factor-alpha	14,46	TGF-alpha	transforming growth factor-alpha	7039	7124	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in cholesteatoma .
10221672	0	TGF-alpha	44,53	transforming_growth_factor_alpha	10,42	TGF-alpha	transforming growth factor alpha	7039	7124	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- in human cerebrospinal fluid .
7858746	0	TGF-alpha	45,54	transforming_growth_factor_alpha	11,43	TGF-alpha	transforming growth factor alpha	7039	7124	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- on DNA synthesis and thyrotropin-induced iodine metabolism in cultured porcine thyroid cells .
8455929	0	TGF-alpha	42,51	transforming_growth_factor_alpha	8,40	TGF-alpha	transforming growth factor alpha	24827(Tax:10116)	24827(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- in the transformation of ras-transfected rat intestinal epithelial cells .
9147239	0	TGF-alpha	48,57	transforming_growth_factor_alpha	14,46	TGF-alpha	transforming growth factor alpha	21802(Tax:10090)	21802(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- gene in mouse embryonic development .
9399568	0	TGF-alpha	50,59	transforming_growth_factor_alpha	16,48	TGF-alpha	transforming growth factor alpha	7039	7124	Gene	Gene	Construction|appos|START_ENTITY Construction|nmod|END_ENTITY	Construction of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- phage library and identification of high binders of epidermal_growth_factor_receptor -LRB- EGFR -RRB- by phage display .
9820173	0	TGF-alpha	67,76	transforming_growth_factor_alpha	33,65	TGF-alpha	transforming growth factor alpha	7039	7124	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lack of interleukin_6 -LRB- IL-6 -RRB- and transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- expression in chromophobe renal_cell_carcinomas .
22119715	0	TGF-b	0,5	AKT	114,117	TGF-b	AKT	21803(Tax:10090)	11651(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|down-regulation down-regulation|nmod|p21 p21|nmod|pathway pathway|compound|END_ENTITY	TGF-b promotes proliferation of thyroid epithelial cells in IFN-y -LRB- - / - -RRB- mice by down-regulation of p21 and p27 via AKT pathway .
22706160	0	TGF-b	70,75	AKT	21,24	TGF-b	AKT	7040	207	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-b type I receptor .
26709509	0	TGF-b	59,64	ATF3	46,50	TGF-b	ATF3	7040	467	Gene	Gene	Pathway|compound|START_ENTITY END_ENTITY|nmod|Pathway	TGRL Lipolysis Products Induce Stress Protein ATF3 via the TGF-b Receptor Pathway in Human Aortic Endothelial Cells .
25345602	0	TGF-b	36,41	Angiotensin_II	0,14	TGF-b	Angiotensin II	7040	183	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates canonical TGF-b signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction .
25676696	0	TGF-b	48,53	Angiotensin_II	12,26	TGF-b	Angiotensin II	7040	183	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Erratum to : Angiotensin_II stimulates canonical TGF-b signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction .
21109559	0	TGF-b	20,25	Arkadia	0,7	TGF-b	Arkadia	7040	54778	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|dep|pathway	Arkadia -- beyond the TGF-b pathway .
22614805	0	TGF-b	0,5	B7H1	50,54	TGF-b	B7H1	7040	29126	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	TGF-b of lung_cancer microenvironment upregulates B7H1 and GITRL expression in dendritic cells and is associated with regulatory T cell generation .
26415510	0	TGF-b	15,20	BARD1	0,5	TGF-b	BARD1	7040	580	Gene	Gene	START_ENTITY|nsubj|mediates mediates|compound|END_ENTITY	BARD1 mediates TGF-b signaling in pulmonary_fibrosis .
24934313	0	TGF-b	81,86	C-type_natriuretic_peptide	37,63	TGF-b	C-type natriuretic peptide	7040	4880	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Matrilin-3 as a putative effector of C-type_natriuretic_peptide signaling during TGF-b induced chondrogenic differentiation of mesenchymal stem cells .
21760921	0	TGF-b	25,30	CCN2	0,4	TGF-b	CCN2	7040	1490	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	CCN2 is required for the TGF-b induced activation of Smad1-Erk1 / 2 signaling network .
25354561	0	TGF-b	14,19	CCN2	0,4	TGF-b	CCN2	21803(Tax:10090)	14219(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	CCN2 requires TGF-b signalling to regulate CCAAT/enhancer binding proteins and inhibit fat cell differentiation .
21655250	0	TGF-b	76,81	CCR6	36,40	TGF-b	CCR6	21803(Tax:10090)	12458(Tax:10090)	Gene	Gene	facilitated|nmod|START_ENTITY facilitated|nmod|proliferation proliferation|nmod|+ +|compound|END_ENTITY	In situ prior proliferation of CD4 + CCR6 + regulatory T cells facilitated by TGF-b secreting DCs is crucial for their enrichment and suppression in tumor immunity .
26621871	0	TGF-b	20,25	CD109	8,13	TGF-b	CD109	7040	135228	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	Soluble CD109 binds TGF-b and antagonizes TGF-b signaling and responses .
21314640	0	TGF-b	106,111	CD25	26,30	TGF-b	CD25	7040	3669	Gene	Gene	production|amod|START_ENTITY contact|nmod|production requires|dobj|contact requires|nsubj|effect effect|nmod|cells cells|nummod|END_ENTITY	The suppressive effect of CD25 + Treg cells on Th1 differentiation requires cell-cell contact partially via TGF-b production .
24454972	0	TGF-b	12,17	CD25	34,38	TGF-b	CD25	7040	3559	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
26067079	0	TGF-b	132,137	CD25	4,8	TGF-b	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	Transgenic_Mice|nmod|START_ENTITY Hepatocytotoxicity|nmod|Transgenic_Mice Killer|dobj|Hepatocytotoxicity Killer|nsubj|Natural Natural|compound|END_ENTITY	CD4 + CD25 + Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis_B_Virus Transgenic_Mice via Membrane-Bound TGF-b and OX40 .
20540113	0	TGF-b	0,5	CD4	94,97	TGF-b	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	interactions|amod|START_ENTITY trigger|nsubj|interactions trigger|nmod|T T|compound|END_ENTITY	TGF-b interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4 -LRB- + -RRB- T cells .
21057085	0	TGF-b	74,79	CD4	94,97	TGF-b	CD4	7040	920	Gene	Gene	agonists|nmod|START_ENTITY agonists|dep|convert convert|dobj|CD25 CD25|compound|END_ENTITY	Peroxisome proliferator-activated receptor a and y agonists together with TGF-b convert human CD4 + CD25 - T cells into functional Foxp3 + regulatory T cells .
21124798	0	TGF-b	0,5	CD4	47,50	TGF-b	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
21494571	0	TGF-b	41,46	CD4	7,10	TGF-b	CD4	7040	920	Gene	Gene	form|nmod|START_ENTITY produce|dobj|form produce|nsubj|cells cells|compound|END_ENTITY	Murine CD4 T cells produce a new form of TGF-b as measured by a newly developed TGF-b bioassay .
21494571	0	TGF-b	80,85	CD4	7,10	TGF-b	CD4	7040	920	Gene	Gene	bioassay|amod|START_ENTITY measured|nmod|bioassay produce|advcl|measured produce|nsubj|cells cells|compound|END_ENTITY	Murine CD4 T cells produce a new form of TGF-b as measured by a newly developed TGF-b bioassay .
21655250	0	TGF-b	76,81	CD4	31,34	TGF-b	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	facilitated|nmod|START_ENTITY facilitated|nmod|proliferation proliferation|nmod|+ +|compound|END_ENTITY	In situ prior proliferation of CD4 + CCR6 + regulatory T cells facilitated by TGF-b secreting DCs is crucial for their enrichment and suppression in tumor immunity .
21839859	0	TGF-b	42,47	CD4	0,3	TGF-b	CD4	59086(Tax:10116)	24932(Tax:10116)	Gene	Gene	bronchiolitis|amod|START_ENTITY induced|nmod|bronchiolitis cells|acl|induced +|dobj|cells +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + Foxp3 + regulatory T cells induced by TGF-b , IL-2 and all-trans_retinoic_acid attenuate obliterative bronchiolitis in rat trachea transplantation .
22728763	0	TGF-b	80,85	CD4	89,92	TGF-b	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nmod|cells cells|compound|END_ENTITY	Targeting Janus_tyrosine_kinase_3 -LRB- JAK3 -RRB- with an inhibitor induces secretion of TGF-b by CD4 + T cells .
23741351	0	TGF-b	0,5	CD4	70,73	TGF-b	CD4	7040	920	Gene	Gene	differentiation|amod|START_ENTITY differentiation|nmod|+ +|compound|END_ENTITY	TGF-b enhanced IL-21-induced differentiation of human IL-21-producing CD4 + T cells via Smad3 .
23844100	0	TGF-b	54,59	CD4	33,36	TGF-b	CD4	7040	920	Gene	Gene	T|nmod|START_ENTITY T|nmod|induction induction|nmod|CD8a CD8a|compound|END_ENTITY	In vitro induction of regulatory CD4 + CD8a + T cells by TGF-b , IL-7_and_IFN-y .
24115907	0	TGF-b	0,5	CD4	33,36	TGF-b	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY required|nsubjpass|signalling required|nmod|homeostasis homeostasis|compound|END_ENTITY	TGF-b signalling is required for CD4 T cell homeostasis but dispensable for regulatory T cell function .
24454972	0	TGF-b	12,17	CD4	28,31	TGF-b	CD4	7040	920	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
25132806	0	TGF-b	38,43	CD4	24,27	TGF-b	CD4	7040	920	Gene	Gene	START_ENTITY|nsubj|percentage percentage|nmod|Foxp3 Foxp3|compound|END_ENTITY	Decreased percentage of CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- TGF-b -LRB- + -RRB- and increased percentage of CD4 -LRB- + -RRB- IL-17 -LRB- + -RRB- cells in bronchoalveolar lavage of asthmatics .
26067079	0	TGF-b	132,137	CD4	0,3	TGF-b	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	Transgenic_Mice|nmod|START_ENTITY Hepatocytotoxicity|nmod|Transgenic_Mice Killer|dobj|Hepatocytotoxicity Killer|nsubj|Natural Natural|compound|END_ENTITY	CD4 + CD25 + Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis_B_Virus Transgenic_Mice via Membrane-Bound TGF-b and OX40 .
26541894	0	TGF-b	0,5	CD4	60,63	TGF-b	CD4	7040	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|compound|differentiation differentiation|nmod|T T|compound|END_ENTITY	TGF-b induces the differentiation of human CXCL13-producing CD4 -LRB- + -RRB- T cells .
26708888	0	TGF-b	78,83	CD4	32,35	TGF-b	CD4	7040	920	Gene	Gene	mRNA|compound|START_ENTITY Cells|appos|mRNA -LSB-|dep|Cells -LSB-|dobj|Expression Expression|nmod|CD25 CD25|compound|END_ENTITY	-LSB- Expression and Significance of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- CDl27 -LRB- low -RRB- Regulatory T Cells , TGF-b and Notch1 mRNA in Patients with Idiopathic_Thrombocytopenic_Purpura -RSB- .
27075967	0	TGF-b	89,94	CD4	25,28	TGF-b	CD4	7040	920	Gene	Gene	binding|nmod|START_ENTITY cells|nmod|binding cells|nsubj|Foxp3 Foxp3|compound|END_ENTITY	Human macrophages induce CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via binding and re-release of TGF-b .
21712621	0	TGF-b	19,24	CD47	0,4	TGF-b	CD47	21803(Tax:10090)	16423(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	CD47 regulates the TGF-b signaling pathway in osteoblasts and is distributed in Meckel 's cartilage .
22718263	0	TGF-b	122,127	CD5	108,111	TGF-b	CD5	21803(Tax:10090)	12507(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic_airway_disease are CD5 + , express TGF-b , and co-localize with CD4 + Foxp3 + T cells .
24569779	0	TGF-b	0,5	CD70	18,22	TGF-b	CD70	7040	970	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	TGF-b upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell_non-Hodgkin 's _ lymphoma .
25544576	0	TGF-b	0,5	COX-2	17,22	TGF-b	COX-2	7040	5743	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Suppresses COX-2 Expression by Tristetraprolin-Mediated RNA Destabilization in A549 Human Lung Cancer Cells .
26252654	0	TGF-b	0,5	CXCL1	27,32	TGF-b	CXCL1	7040	2919	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26252654	0	TGF-b	0,5	CXCL1	27,32	TGF-b	CXCL1	7040	2919	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
24069422	0	TGF-b	36,41	Cadherin_6	0,10	TGF-b	Cadherin 6	7040	1004	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cadherin_6 is a new RUNX2 target in TGF-b signalling pathway .
26356269	0	TGF-b	0,5	Chondroitin_Sulfate_Synthase_1	31,61	TGF-b	Chondroitin Sulfate Synthase 1	59086(Tax:10116)	292999(Tax:10116)	Gene	Gene	Up-Regulation|compound|START_ENTITY Up-Regulation|nmod|END_ENTITY	TGF-b Induces Up-Regulation of Chondroitin_Sulfate_Synthase_1 -LRB- CHSY1 -RRB- in Nucleus Pulposus Cells Through MAPK Signaling .
21980391	0	TGF-b	0,5	DNA_methyltransferase	16,37	TGF-b	DNA methyltransferase	7040	1786	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	TGF-b regulates DNA_methyltransferase expression in prostate_cancer , correlates with aggressive capabilities , and predicts disease recurrence .
24638085	0	TGF-b	80,85	Dab2	8,12	TGF-b	Dab2	7040	1601	Gene	Gene	deplete|dobj|START_ENTITY ability|acl|deplete impairs|dobj|ability impairs|nsubj|Loss Loss|nmod|expression expression|amod|END_ENTITY	Loss of Dab2 expression in breast_cancer cells impairs their ability to deplete TGF-b and induce Tregs development via TGF-b .
24648493	0	TGF-b	61,66	Dab2	0,4	TGF-b	Dab2	7040	1601	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-b .
25518932	0	TGF-b	46,51	EMT	65,68	TGF-b	EMT	7040	3702	Gene	Gene	START_ENTITY|xcomp|Signaling Signaling|nmod|END_ENTITY	Itch E3 Ubiquitin Ligase Positively Regulates TGF-b Signaling to EMT via Smad7 Ubiquitination .
25656846	0	TGF-b	27,32	EWI-2	0,5	TGF-b	EWI-2	7040	93185	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	EWI-2 negatively regulates TGF-b signaling leading to altered melanoma growth and metastasis .
26989766	0	TGF-b	40,45	EWI-2	16,21	TGF-b	EWI-2	7040	93185	Gene	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	Novel impact of EWI-2 , CD9 , and CD81 on TGF-b signaling in melanoma .
25139621	0	TGF-b	20,25	Erg	0,3	TGF-b	Erg	7040	2078	Gene	Gene	cooperates|advcl|START_ENTITY cooperates|nsubj|END_ENTITY	Erg cooperates with TGF-b to control mesenchymal differentiation .
25374926	0	TGF-b	0,5	FGF-2	19,24	TGF-b	FGF-2	21803(Tax:10090)	14173(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	TGF-b induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways .
24454972	0	TGF-b	12,17	FOXP3	42,47	TGF-b	FOXP3	7040	50943	Gene	Gene	cells|nummod|START_ENTITY cells|compound|END_ENTITY	Increase in TGF-b secreting CD4 CD25 FOXP3 T regulatory cells in anergic lepromatous_leprosy patients .
26607280	0	TGF-b	31,36	Fibulin-4	0,9	TGF-b	Fibulin-4	21803(Tax:10090)	58859(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Fibulin-4 deficiency increases TGF-b signalling in aortic smooth muscle cells due to elevated TGF-b2 levels .
20876311	0	TGF-b	95,100	Foxp3	42,47	TGF-b	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY induce|nmod|pathway induce|dobj|expression expression|compound|END_ENTITY	Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-b pathway .
21057085	0	TGF-b	74,79	Foxp3	128,133	TGF-b	Foxp3	7040	50943	Gene	Gene	agonists|nmod|START_ENTITY agonists|parataxis|+ +|nsubj|cells cells|nmod|END_ENTITY	Peroxisome proliferator-activated receptor a and y agonists together with TGF-b convert human CD4 + CD25 - T cells into functional Foxp3 + regulatory T cells .
21124798	0	TGF-b	0,5	Foxp3	74,79	TGF-b	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|nmod|induction induction|amod|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
21839859	0	TGF-b	42,47	Foxp3	5,10	TGF-b	Foxp3	59086(Tax:10116)	317382(Tax:10116)	Gene	Gene	bronchiolitis|amod|START_ENTITY induced|nmod|bronchiolitis cells|acl|induced +|dobj|cells +|nsubj|END_ENTITY	CD4 + Foxp3 + regulatory T cells induced by TGF-b , IL-2 and all-trans_retinoic_acid attenuate obliterative bronchiolitis in rat trachea transplantation .
22156591	0	TGF-b	24,29	Foxp3	82,87	TGF-b	Foxp3	7040	50943	Gene	Gene	Rapamycin|nmod|START_ENTITY converts|nsubj|Rapamycin converts|nmod|END_ENTITY	Rapamycin combined with TGF-b converts human invariant NKT cells into suppressive Foxp3 + regulatory cells .
25132806	0	TGF-b	38,43	Foxp3	30,35	TGF-b	Foxp3	7040	50943	Gene	Gene	START_ENTITY|nsubj|percentage percentage|nmod|END_ENTITY	Decreased percentage of CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- TGF-b -LRB- + -RRB- and increased percentage of CD4 -LRB- + -RRB- IL-17 -LRB- + -RRB- cells in bronchoalveolar lavage of asthmatics .
27075967	0	TGF-b	89,94	Foxp3	31,36	TGF-b	Foxp3	7040	50943	Gene	Gene	binding|nmod|START_ENTITY cells|nmod|binding cells|nsubj|END_ENTITY	Human macrophages induce CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells via binding and re-release of TGF-b .
18452556	0	TGF-b	108,113	GATA-2	83,89	TGF-b	GATA-2	21803(Tax:10090)	14461(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Evi-1 promotes para-aortic splanchnopleural_hematopoiesis through up-regulation of GATA-2 and repression of TGF-b signaling .
22395235	0	TGF-b	10,15	Gli2	19,23	TGF-b	Gli2	7040	2736	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of TGF-b on Gli2 expression in HL60 and U937 cell lines .
26950997	0	TGF-b	67,72	HBD-2	53,58	TGF-b	HBD-2	7040	1673	Gene	Gene	TLR2|dep|START_ENTITY TLR2|dep|END_ENTITY	-LSB- STUDY OF THE ROLE OF INNATE IMMUNITY FACTORS -LRB- TLR2 , HBD-2 , TNF-a , TGF-b -RRB- IN PERIODONTITIS PATHOGENESIS -RSB- .
26627200	0	TGF-b	0,5	HLA-G	14,19	TGF-b	HLA-G	7040	3135	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	TGF-b induces HLA-G expression through inhibiting miR-152 in gastric_cancer cells .
24613385	0	TGF-b	36,41	Hsp70	0,5	TGF-b	Hsp70	7040	3308	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Hsp70 and Hsp90 oppositely regulate TGF-b signaling through CHIP/Stub1 .
21601308	0	TGF-b	94,99	IL-10	34,39	TGF-b	IL-10	7040	3586	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|peptide peptide|nmod|domain domain|amod|functional functional|amod|END_ENTITY	A synthetic peptide homologous to IL-10 functional domain induces monocyte differentiation to TGF-b + tolerogenic dendritic cells .
21728174	0	TGF-b	0,5	IL-10	33,38	TGF-b	IL-10	21803(Tax:10090)	16153(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY drives|nsubj|signaling drives|dobj|production production|compound|END_ENTITY	TGF-b signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE .
24521472	0	TGF-b	74,79	IL-10	68,73	TGF-b	IL-10	7040	3586	Gene	Gene	yields|nsubj|START_ENTITY END_ENTITY|appos|yields	An optimized protocol for human M2 macrophages using M-CSF and IL-4 / IL-10 / TGF-b yields a dominant immunosuppressive phenotype .
27049572	0	TGF-b	18,23	IL-10	25,30	TGF-b	IL-10	7040	3586	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	A study of TNF-a , TGF-b , IL-10 , IL-6 , and IFN-y gene polymorphisms in patients with depression .
24485804	0	TGF-b	58,63	IRF8	25,29	TGF-b	IRF8	21803(Tax:10090)	15900(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The transcription factor IRF8 activates integrin-mediated TGF-b signaling and promotes neuroinflammation .
25828538	0	TGF-b	0,5	Ift88	17,22	TGF-b	Ift88	7040	8100	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells .
25518932	0	TGF-b	46,51	Itch	0,4	TGF-b	Itch	7040	83737	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	Itch E3 Ubiquitin Ligase Positively Regulates TGF-b Signaling to EMT via Smad7 Ubiquitination .
22728763	0	TGF-b	80,85	Janus_tyrosine_kinase_3	10,33	TGF-b	Janus tyrosine kinase 3	21803(Tax:10090)	16453(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Targeting Janus_tyrosine_kinase_3 -LRB- JAK3 -RRB- with an inhibitor induces secretion of TGF-b by CD4 + T cells .
21124798	0	TGF-b	0,5	LAP	22,25	TGF-b	LAP	21803(Tax:10090)	219103(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TGF-b induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction .
26379781	0	TGF-b	6,11	LAP	12,15	TGF-b	LAP	21803(Tax:10090)	219103(Tax:10090)	Gene	Gene	START_ENTITY|ccomp|serve serve|nsubj|products products|compound|END_ENTITY	L -LRB- 59 -RRB- TGF-b LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice .
25143398	0	TGF-b	0,5	LARG	16,20	TGF-b	LARG	7040	23365	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TGF-b regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion .
23868260	0	TGF-b	53,58	LRG1	0,4	TGF-b	LRG1	21803(Tax:10090)	76905(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY modulating|dobj|signalling promotes|advcl|modulating promotes|nsubj|END_ENTITY	LRG1 promotes angiogenesis by modulating endothelial TGF-b signalling .
26049667	0	TGF-b	67,72	LRG1	0,4	TGF-b	LRG1	7040	116844	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	LRG1 modulates invasion and migration_of_glioma cell lines through TGF-b signaling pathway .
21577212	0	TGF-b	28,33	MMP-9	42,47	TGF-b	MMP-9	7040	4318	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Absence of Thy-1 results in TGF-b induced MMP-9 expression and confers a profibrotic phenotype to human lung fibroblasts .
24280647	0	TGF-b	88,93	MMP-9	55,60	TGF-b	MMP-9	21803(Tax:10090)	17395(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY critical|nsubj|activation Restoration|parataxis|critical Restoration|nmod|END_ENTITY	Restoration of intrahepatic regulatory T cells through MMP-9 / 13-dependent activation of TGF-b is critical for immune homeostasis following acute liver_injury .
25825495	0	TGF-b	119,124	MMP-9	43,48	TGF-b	MMP-9	7040	4318	Gene	Gene	activation|amod|START_ENTITY triggers|dobj|activation triggers|nsubj|Recruitment Recruitment|nmod|Matrix_Metalloproteinase-9 Matrix_Metalloproteinase-9|appos|END_ENTITY	Recruitment of Matrix_Metalloproteinase-9 -LRB- MMP-9 -RRB- to the fibroblast cell surface by Lysyl_Hydroxylase-3 -LRB- LH3 -RRB- triggers TGF-b activation and fibroblast differentiation .
26395178	0	TGF-b	98,103	MMP13	18,23	TGF-b	MMP13	7040	4322	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-b signalling pathway .
23523906	0	TGF-b	103,108	NF-kB	87,92	TGF-b	NF-kB	59086(Tax:10116)	81736(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Berberine attenuates bleomycin induced pulmonary_toxicity and fibrosis via suppressing NF-kB dependant TGF-b activation : a biphasic experimental study .
22381741	0	TGF-b	39,44	NFkB	61,65	TGF-b	NFkB	59086(Tax:10116)	81736(Tax:10116)	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Sulfasalazine prevents the increase in TGF-b , COX-2 , nuclear NFkB translocation and fibrosis in CCl4-induced liver_cirrhosis in the rat .
22080920	0	TGF-b	0,5	Ndfip1	44,50	TGF-b	Ndfip1	21803(Tax:10090)	65113(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	TGF-b induces the expression of the adaptor Ndfip1 to silence IL-4 production during iTreg cell differentiation .
21131394	0	TGF-b	0,5	Nox4	16,20	TGF-b	Nox4	7040	50507	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TGF-b regulates Nox4 , MnSOD and catalase expression , and IL-6 release in airway smooth muscle cells .
26403732	0	TGF-b	116,121	Nuclear_factor_I-C	1,19	TGF-b	Nuclear factor I-C	7040	4782	Gene	Gene	-RSB-|compound|START_ENTITY inhibits|nmod|-RSB- inhibits|nsubj|END_ENTITY	-LSB- Nuclear_factor_I-C inhibits platelet-derived growth factor-induced enhancement of dermal fibroblast sensitivity to TGF-b -RSB- .
27048878	0	TGF-b	30,35	Nuclear_receptor_TLX	0,20	NR2E1	Nuclear receptor TLX	7101	7101	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Nuclear_receptor_TLX inhibits TGF-b signaling in glioblastoma .
23599148	0	TGF-b	7,12	PTEN	51,55	TGF-b	PTEN	7040	5728	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Active TGF-b signaling and decreased expression of PTEN separates angiosarcoma_of_bone from its soft tissue counterpart .
22394585	0	TGF-b	26,31	Papss2	51,57	TGF-b	Papss2	21803(Tax:10090)	23972(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Altered responsiveness to TGF-b results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage .
25132272	0	TGF-b	0,5	Pten	69,73	TGF-b	Pten	21803(Tax:10090)	19211(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY alters|nsubj|signaling alters|dobj|pattern pattern|nmod|tumorigenesis tumorigenesis|acl|induced induced|nmod|inactivation inactivation|compound|END_ENTITY	TGF-b signaling alters the pattern of liver tumorigenesis induced by Pten inactivation .
22710711	0	TGF-b	0,5	Pyk2	17,21	TGF-b	Pyk2	7040	5747	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	TGF-b stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast_cancer .
24069422	0	TGF-b	36,41	RUNX2	20,25	TGF-b	RUNX2	7040	860	Gene	Gene	target|nmod|START_ENTITY target|compound|END_ENTITY	Cadherin_6 is a new RUNX2 target in TGF-b signalling pathway .
21611174	0	TGF-b	60,65	SMAD2	84,89	TGF-b	SMAD2	21803(Tax:10090)	17126(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Wnt3a induces myofibroblast differentiation by upregulating TGF-b signaling through SMAD2 in a b-catenin-dependent manner .
26039994	0	TGF-b	63,68	SMAD2	44,49	TGF-b	SMAD2	7040	31738(Tax:7227)	Gene	Gene	receptor|amod|START_ENTITY impedes|nmod|receptor impedes|dobj|release release|compound|END_ENTITY	Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-b receptor I to inhibit TGF-b signaling .
26039994	0	TGF-b	91,96	SMAD2	44,49	TGF-b	SMAD2	37778(Tax:7227)	31738(Tax:7227)	Gene	Gene	signaling|amod|START_ENTITY inhibit|dobj|signaling receptor|acl|inhibit impedes|nmod|receptor impedes|dobj|release release|compound|END_ENTITY	Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-b receptor I to inhibit TGF-b signaling .
22511296	0	TGF-b	0,5	SMAD2/3	24,31	TGF-b	SMAD2/3	7040	4087;4088	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	TGF-b signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment .
21874046	0	TGF-b	54,59	SMAD4	74,79	TGF-b	SMAD4	7040	4089	Gene	Gene	transduction|nmod|START_ENTITY regulates|dobj|transduction regulates|advcl|repressing repressing|dobj|END_ENTITY	MicroRNA miR-146b-5p regulates signal transduction of TGF-b by repressing SMAD4 in thyroid_cancer .
26284758	0	TGF-b	76,81	SMAD4	14,19	TGF-b	SMAD4	7040	4089	Gene	Gene	Signaling|compound|START_ENTITY Restoration|nmod|Signaling Loss|nmod|Restoration Loss|nsubj|Insights Insights|nmod|END_ENTITY	Insights Into SMAD4 Loss in Pancreatic_Cancer From Inducible Restoration of TGF-b Signaling .
21898545	0	TGF-b	30,35	SMAD7	102,107	TGF-b	SMAD7	7040	4092	Gene	Gene	receptors|amod|START_ENTITY degradation|nmod|receptors involve|nsubj|degradation involve|dobj|regulation regulation|nmod|END_ENTITY	CD109-mediated degradation of TGF-b receptors and inhibition of TGF-b responses involve regulation of SMAD7 and Smurf2 localization and function .
24935472	0	TGF-b	46,51	SMAD7	0,5	TGF-b	SMAD7	7040	4092	Gene	Gene	signaling|amod|START_ENTITY targeting|dobj|signaling progression|acl|targeting timer|nmod|progression END_ENTITY|dep|timer	SMAD7 : a timer of tumor progression targeting TGF-b signaling .
25983322	0	TGF-b	0,5	SMAD7	84,89	TGF-b	SMAD7	7040	4092	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activation activation|nmod|TGF-b TGF-b|acl|signaling signaling|advcl|inhibiting inhibiting|dobj|expression expression|compound|END_ENTITY	TGF-b induced miR-132 enhances the activation of TGF-b signaling through inhibiting SMAD7 expression in glioma cells .
25983322	0	TGF-b	49,54	SMAD7	84,89	TGF-b	SMAD7	7040	4092	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|inhibiting inhibiting|dobj|expression expression|compound|END_ENTITY	TGF-b induced miR-132 enhances the activation of TGF-b signaling through inhibiting SMAD7 expression in glioma cells .
21266196	0	TGF-b	16,21	SNX25	0,5	TGF-b	SNX25	21803(Tax:10090)	102141(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SNX25 regulates TGF-b signaling by enhancing the receptor degradation .
24357723	0	TGF-b	18,23	Sharp-1	0,7	TGF-b	Sharp-1	21803(Tax:10090)	79362(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	Sharp-1 regulates TGF-b signaling and skeletal muscle regeneration .
25180292	0	TGF-b	26,31	Sirt1	0,5	TGF-b	Sirt1	21803(Tax:10090)	93759(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Sirt1 regulates canonical TGF-b signalling to control fibroblast activation and tissue fibrosis .
23494890	0	TGF-b	50,55	Smad2	15,20	TGF-b	Smad2	7040	4087	Gene	Gene	shows|advcl|START_ENTITY shows|nsubj|Attenuation Attenuation|nmod|activity activity|amod|END_ENTITY	Attenuation of Smad2 activity shows resistance to TGF-b signalling in mammary adenocarcinoma -LRB- MCF-7 -RRB- cells .
25249655	0	TGF-b	116,121	Smad2/3	131,138	TGF-b	Smad2/3	7040	4087;4088	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|activity activity|amod|END_ENTITY	Comment on `` Controlling long-term signaling : receptor dynamics determine attenuation and refractory behavior of the TGF-b pathway '' - Smad2/3 activity does not predict the dynamics of transcription .
25249656	0	TGF-b	128,133	Smad2/3	143,150	TGF-b	Smad2/3	7040	4087;4088	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|activity activity|amod|END_ENTITY	Response to comment on `` Controlling long-term signaling : receptor dynamics determine attenuation and refractory behavior of the TGF-b pathway '' - Smad2/3 activity does not predict the dynamics of transcription .
26252654	0	TGF-b	0,5	Smad2/3	100,107	TGF-b	Smad2/3	7040	4087;4088	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26252654	0	TGF-b	0,5	Smad2/3	100,107	TGF-b	Smad2/3	7040	4087;4088	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	TGF-b Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms .
26424816	0	TGF-b	41,46	Smad2/3	50,57	TGF-b	Smad2/3	7040	4087;4088	Gene	Gene	START_ENTITY|nmod|Activity Activity|amod|END_ENTITY	AMPK Inhibits the Stimulatory Effects of TGF-b on Smad2/3 Activity , Cell Migration and Epithelial to Mesenchymal Transition .
26432290	0	TGF-b	0,5	Smad2/3	66,73	TGF-b	Smad2/3	7040	4087;4088	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	TGF-b induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression .
21305609	0	TGF-b	50,55	Smad3	94,99	TGF-b	Smad3	7040	4088	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Regulation of RANKL-induced osteoclastogenesis by TGF-b through molecular interaction between Smad3 and Traf6 .
22778267	0	TGF-b	41,46	Smad3	48,53	TGF-b	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
21273545	0	TGF-b	98,103	Smad4	0,5	TGF-b	Smad4	21803(Tax:10090)	17128(Tax:10090)	Gene	Gene	branch|nmod|START_ENTITY dependent|nmod|branch processes|amod|dependent required|nmod|processes required|nsubjpass|END_ENTITY	Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-b signaling system in the embryonic mouse retina .
21324314	0	TGF-b	18,23	Smad4	36,41	TGF-b	Smad4	7040	4089	Gene	Gene	role|nmod|START_ENTITY mediated|nsubj|role mediated|nmod|translocation translocation|amod|END_ENTITY	Apoptotic role of TGF-b mediated by Smad4 mitochondria translocation and cytochrome_c_oxidase_subunit_II interaction .
21728174	0	TGF-b	0,5	Smad4	20,25	TGF-b	Smad4	21803(Tax:10090)	17128(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	TGF-b signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE .
22689943	0	TGF-b	12,17	Smad4	130,135	TGF-b	Smad4	397778(Tax:8355)	780764(Tax:8355)	Gene	Gene	signaling|compound|START_ENTITY Dynamics|nmod|signaling reveal|nsubj|Dynamics reveal|ccomp|reflected reflected|nmod|localization localization|nmod|END_ENTITY	Dynamics of TGF-b signaling reveal adaptive and pulsatile_behaviors reflected in the nuclear localization of transcription factor Smad4 .
22821565	0	TGF-b	95,100	Smad4	42,47	TGF-b	Smad4	7040	4089	Gene	Gene	pathway|amod|START_ENTITY regulator|nmod|pathway identified|nmod|regulator identified|nsubj|screening screening|nmod|END_ENTITY	Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-b signalling pathway .
21931165	0	TGF-b	88,93	Smad7	32,37	TGF-b	Smad7	21803(Tax:10090)	17131(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The deubiquitinase CYLD targets Smad7 protein to regulate transforming_growth_factor_b -LRB- TGF-b -RRB- signaling and the development of regulatory T cells .
22286770	0	TGF-b	49,54	Smad7	32,37	TGF-b	Smad7	7040	4092	Gene	Gene	signaling|compound|START_ENTITY activates|dobj|signaling activates|ccomp|targets targets|dobj|END_ENTITY	The miR-106b-25 cluster targets Smad7 , activates TGF-b signaling , and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast_cancer .
22921829	0	TGF-b	86,91	Smad7	51,56	TGF-b	Smad7	7040	4092	Gene	Gene	Pathways|compound|START_ENTITY domains|nmod|Pathways WW|dobj|domains WW|nsubj|basis basis|nmod|interactions interactions|nmod|END_ENTITY	Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-b Pathways .
24369345	0	TGF-b	50,55	Smad7	33,38	TGF-b	Smad7	7040	4092	Gene	Gene	inhibit|dobj|START_ENTITY synergizes|xcomp|inhibit synergizes|nmod|END_ENTITY	Yin_Yang_1 -LRB- YY1 -RRB- synergizes with Smad7 to inhibit TGF-b signaling in the nucleus .
25518932	0	TGF-b	46,51	Smad7	73,78	TGF-b	Smad7	7040	4092	Gene	Gene	START_ENTITY|xcomp|Signaling Signaling|nmod|EMT EMT|nmod|Ubiquitination Ubiquitination|compound|END_ENTITY	Itch E3 Ubiquitin Ligase Positively Regulates TGF-b Signaling to EMT via Smad7 Ubiquitination .
26859364	0	TGF-b	17,22	Smad7	0,5	TGF-b	Smad7	7040	4092	Gene	Gene	START_ENTITY|nsubj|interrupts interrupts|amod|END_ENTITY	Smad7 interrupts TGF-b signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing_enterocolitis .
25472740	0	TGF-b	92,97	Surfactant_protein_D	0,20	TGF-b	Surfactant protein D	21803(Tax:10090)	20390(Tax:10090)	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Surfactant_protein_D attenuates sub-epithelial fibrosis in allergic_airways_disease through TGF-b .
25394915	0	TGF-b	117,122	TGF-b	93,98	TGF-b	TGF-b	7040	7040	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	CCNs , fibulin-1C and S100A4 expression in leiomyoma and myometrium : inverse association with TGF-b and regulation by TGF-b in leiomyoma and myometrial smooth muscle cells .
25394915	0	TGF-b	93,98	TGF-b	117,122	TGF-b	TGF-b	7040	7040	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	CCNs , fibulin-1C and S100A4 expression in leiomyoma and myometrium : inverse association with TGF-b and regulation by TGF-b in leiomyoma and myometrial smooth muscle cells .
26419316	0	TGF-b	17,22	TGF-b	46,51	TGF-b	TGF-b	7040	7040	Gene	Gene	START_ENTITY|nmod|Receptors Receptors|compound|END_ENTITY	Ethanol Enhances TGF-b Activity by Recruiting TGF-b Receptors From Intracellular Vesicles/Lipid Rafts/Caveolae to Non-Lipid Raft Microdomains .
26419316	0	TGF-b	46,51	TGF-b	17,22	TGF-b	TGF-b	7040	7040	Gene	Gene	Receptors|compound|START_ENTITY END_ENTITY|nmod|Receptors	Ethanol Enhances TGF-b Activity by Recruiting TGF-b Receptors From Intracellular Vesicles/Lipid Rafts/Caveolae to Non-Lipid Raft Microdomains .
26498464	0	TGF-b	27,32	TGF-b1	19,25	TGF-b	TGF-b1	7040	7040	Gene	Gene	receptor|dep|START_ENTITY receptor|compound|END_ENTITY	Down-regulation of TGF-b1 , TGF-b receptor 2 , and TGF-b-associated microRNAs , miR-20a and miR-21 , in skin_lesions of sulfur mustard-exposed Iranian war veterans .
26915797	0	TGF-b	0,5	TGFBIp	16,22	TGF-b	TGFBIp	7040	7045	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	TGF-b regulates TGFBIp expression in corneal fibroblasts via miR-21 , miR-181a , and Smad signaling .
24933703	0	TGF-b	16,21	TMEPAI	0,6	TGF-b	TMEPAI	7040	56937	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	TMEPAI inhibits TGF-b signaling by promoting lysosome degradation of TGF-b receptor and contributes to lung_cancer development .
24933703	0	TGF-b	69,74	TMEPAI	0,6	TGF-b	TMEPAI	7040	56937	Gene	Gene	receptor|amod|START_ENTITY degradation|nmod|receptor promoting|dobj|degradation signaling|advcl|promoting TGF-b|acl|signaling inhibits|dobj|TGF-b inhibits|nsubj|END_ENTITY	TMEPAI inhibits TGF-b signaling by promoting lysosome degradation of TGF-b receptor and contributes to lung_cancer development .
20652825	0	TGF-b	38,43	TNF-a	0,5	TGF-b	TNF-a	21803(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|expression expression|amod|END_ENTITY	TNF-a mRNA expression correlates with TGF-b mRNA expression in vivo .
21893029	0	TGF-b	68,73	TNF-a	0,5	TGF-b	TNF-a	59086(Tax:10116)	24835(Tax:10116)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	TNF-a increases cardiac fibroblast lysyl_oxidase expression through TGF-b and PI3Kinase signaling pathways .
23110133	0	TGF-b	121,126	TNF-a	95,100	TGF-b	TNF-a	59086(Tax:10116)	24835(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-a in combination with TGF-b in rats .
23319875	0	TGF-b	8,13	TNF-a	79,84	TGF-b	TNF-a	7040	7124	Gene	Gene	Role|nmod|START_ENTITY Role|dep|Suppression Suppression|nmod|Production Production|compound|END_ENTITY	Role of TGF-b in Survival of Phagocytizing Microglia : Autocrine Suppression of TNF-a Production and Oxidative Stress .
23638863	0	TGF-b	62,67	TNF-a	55,60	TGF-b	TNF-a	7040	7124	Gene	Gene	IL6|dep|START_ENTITY IL6|dep|END_ENTITY	Association of cytokine gene polymorphisms -LRB- IL6 , IL10 , TNF-a , TGF-b and IFN-y -RRB- and Graves ' _ disease in Turkish population .
25009639	0	TGF-b	29,34	TNF-a	0,5	TGF-b	TNF-a	7040	7124	Gene	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	TNF-a enhances the effect of TGF-b on Gli2 expression in the KG-1 leukemic cell line .
26729808	0	TGF-b	136,141	TNF-a	14,19	TGF-b	TNF-a	7040	7124	Gene	Gene	Implications|compound|START_ENTITY Reverse|nmod|Implications Reverse|nsubj|END_ENTITY	Transmembrane TNF-a Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-b : Therapeutic Implications .
27049572	0	TGF-b	18,23	TNF-a	11,16	TGF-b	TNF-a	7040	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|amod|END_ENTITY	A study of TNF-a , TGF-b , IL-10 , IL-6 , and IFN-y gene polymorphisms in patients with depression .
26807171	0	TGF-b	88,93	TNF_receptor-associated_factor_6	0,32	TGF-b	TNF receptor-associated factor 6	59086(Tax:10116)	311245(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TNF_receptor-associated_factor_6 -LRB- TRAF6 -RRB- mediates the angiotensin-induced non-canonical TGF-b pathway activation of c-kit -LRB- + -RRB- cardiac stem cells .
25068659	0	TGF-b	22,27	TRPA1	0,5	TGF-b	TRPA1	21803(Tax:10090)	277328(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nmod|signaling required|nsubjpass|END_ENTITY	TRPA1 is required for TGF-b signaling and its loss_blocks inflammatory fibrosis in mouse corneal_stroma .
23747528	0	TGF-b	41,46	Thioredoxin	0,11	TGF-b	Thioredoxin	21803(Tax:10090)	22166(Tax:10090)	Gene	Gene	MPK38-induced|nummod|START_ENTITY function|nsubj|MPK38-induced inhibits|ccomp|function inhibits|nsubj|END_ENTITY	Thioredoxin inhibits MPK38-induced ASK1 , TGF-b , and p53 function in a phosphorylation-dependent manner .
22583901	0	TGF-b	100,105	Thrombospondin-1	0,16	TGF-b	Thrombospondin-1	7040	7057	Gene	Gene	activation|compound|START_ENTITY inhibits|nmod|activation inhibits|nsubj|END_ENTITY	Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-b activation .
25269071	0	TGF-b	30,35	Transforming_Growth_Factor-b	0,28	TGF-b	Transforming Growth Factor-b	7040	7040	Gene	Gene	Expression|appos|START_ENTITY Expression|amod|END_ENTITY	Transforming_Growth_Factor-b -LRB- TGF-b -RRB- Expression Is Increased in the Subsynovial Connective Tissue in a Rabbit Model of Carpal_Tunnel_Syndrome .
24014274	0	TGF-b	30,35	Transforming_growth_factor-b	0,28	TGF-b	Transforming growth factor-b	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-b -LRB- TGF-b -RRB- expression is increased in the subsynovial connective tissues of patients with idiopathic carpal_tunnel_syndrome .
21104643	0	TGF-b	30,35	Transforming_growth_factor_b	0,28	TGF-b	Transforming growth factor b	7040	7040	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Transforming_growth_factor_b -LRB- TGF-b -RRB- levels in otherwise healthy subjects with impaired_glucose_tolerance .
21409414	0	TGF-b	163,168	VEGF	209,213	TGF-b	VEGF	7040	7422	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-b and vascular_endothelial_growth_factor -LRB- VEGF -RRB- by pericytes .
26108893	0	TGF-b	11,16	Wnt1	44,48	TGF-b	Wnt1	21803(Tax:10090)	22408(Tax:10090)	Gene	Gene	START_ENTITY|dobj|Secretion Secretion|compound|END_ENTITY	Osteoclast TGF-b Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation .
26108893	0	TGF-b	11,16	Wnt1	44,48	TGF-b	Wnt1	21803(Tax:10090)	22408(Tax:10090)	Gene	Gene	START_ENTITY|dobj|Secretion Secretion|compound|END_ENTITY	Osteoclast TGF-b Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation .
23861379	0	TGF-b	0,5	Wnt10b	14,20	TGF-b	Wnt10b	21803(Tax:10090)	22410(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TGF-b induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts .
26983758	0	TGF-b	85,90	beta-2-microglobulin	44,64	TGF-b	beta-2-microglobulin	7040	567	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Human_epithelial-type_ovarian_tumour marker beta-2-microglobulin is regulated by the TGF-b signaling pathway .
21913799	0	TGF-b	0,5	biglycan	17,25	TGF-b	biglycan	7040	633	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|amod|END_ENTITY	TGF-b stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle .
21971976	0	TGF-b	17,22	extracellular_signal-regulated_kinase_1_and_2	45,90	TGF-b	extracellular signal-regulated kinase 1 and 2	7040	5594	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Up-regulation of TGF-b via the activation of extracellular_signal-regulated_kinase_1_and_2 induced by prorenin in human renal_mesangial_cells .
20887202	0	TGF-b	87,92	foxp3	40,45	TGF-b	foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|nsubj|END_ENTITY	Retinal pigment epithelial cells induce foxp3 -LRB- + -RRB- regulatory T cells via membrane-bound TGF-b .
21762647	0	TGF-b	61,66	interleukin-6	8,21	TGF-b	interleukin-6	7040	3569	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Urinary interleukin-6 -LRB- IL-6 -RRB- and transforming growth factor -LRB- TGF-b -RRB- levels in corticosteroidtreated patients with IgA_nephropathy .
25983322	0	TGF-b	0,5	miR-132	14,21	TGF-b	miR-132	7040	406921	Gene	Gene	START_ENTITY|acl|induced induced|xcomp|END_ENTITY	TGF-b induced miR-132 enhances the activation of TGF-b signaling through inhibiting SMAD7 expression in glioma cells .
22570175	0	TGF-b	14,19	miR-146b	80,88	TGF-b	miR-146b	59086(Tax:10116)	100314121(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Growth_factor TGF-b induces intestinal epithelial cell -LRB- IEC-6 -RRB- differentiation : miR-146b as a regulatory component in the negative feedback loop .
23241956	0	TGF-b	0,5	miR-181a	18,26	TGF-b	miR-181a	7040	387176(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	TGF-b upregulates miR-181a expression to promote breast_cancer metastasis .
23006329	0	TGF-b	0,5	miR-182	14,21	TGF-b	miR-182	7040	406958	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	TGF-b induces miR-182 to sustain NF-kB activation in glioma subsets .
24445397	0	TGF-b	0,5	miR-182	18,25	TGF-b	miR-182	7040	406958	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	TGF-b upregulates miR-182 expression to promote gallbladder_cancer metastasis by targeting CADM1 .
23249391	0	TGF-b	0,5	mucin	49,54	TGF-b	mucin	7040	100508689	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|compound|END_ENTITY	TGF-b decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells .
22119715	0	TGF-b	0,5	p21	98,101	TGF-b	p21	21803(Tax:10090)	12575(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|down-regulation down-regulation|nmod|END_ENTITY	TGF-b promotes proliferation of thyroid epithelial cells in IFN-y -LRB- - / - -RRB- mice by down-regulation of p21 and p27 via AKT pathway .
26963853	0	TGF-b	0,5	p27kip1	95,102	TGF-b	p27kip1	7040	1027	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	TGF-b activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth .
22965824	0	TGF-b	80,85	p38	96,99	TGF-b	p38	7040	1432	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Microarray analysis of Dupuytren 's _ disease cells : the profibrogenic role of the TGF-b inducible p38 MAPK pathway .
26096942	0	TGF-b	95,100	p53	60,63	TGF-b	p53	7040	7157	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-b pathway .
26096942	0	TGF-b	95,100	p53	60,63	TGF-b	p53	7040	7157	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-b pathway .
26120963	0	TGF-b	62,67	p75	35,38	TGF-b	p75	21803(Tax:10090)	18053(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|controls controls|amod|END_ENTITY	Nuclear pore complex remodeling by p75 -LRB- NTR -RRB- cleavage controls TGF-b signaling and astrocyte functions .
22155511	0	TGF-b	0,5	sclerostin	16,26	TGF-b	sclerostin	59086(Tax:10116)	80722(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TGF-b regulates sclerostin expression via the ECR5 enhancer .
25374926	0	TGF-b	0,5	smad3	73,78	TGF-b	smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY requires|nsubj|induction requires|dobj|END_ENTITY	TGF-b induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways .
20458184	0	TGF-b	57,62	transforming_growth_factor-b	27,55	TGF-b	transforming growth factor-b	7040	7040	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Regulation of autophagy by transforming_growth_factor-b -LRB- TGF-b -RRB- signaling .
22707720	0	TGF-b	76,81	transforming_growth_factor-b	46,74	TGF-b	transforming growth factor-b	7040	7040	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Coated pit-mediated endocytosis of the type I transforming_growth_factor-b -LRB- TGF-b -RRB- receptor depends on a di-leucine family signal and is not required for signaling .
22778267	0	TGF-b	41,46	transforming_growth_factor-b	11,39	TGF-b	transforming growth factor-b	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
25714613	0	TGF-b	65,70	transforming_growth_factor-b	35,63	TGF-b	transforming growth factor-b	7040	7040	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	The immune suppressive function of transforming_growth_factor-b -LRB- TGF-b -RRB- in human diseases .
21081531	0	TGF-b	49,54	transforming_growth_factor_b	20,48	TGF-b	transforming growth factor b	7040	7040	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Altered dynamics of transforming_growth_factor_b -LRB- TGF-b -RRB- receptors in scleroderma fibroblasts .
22337877	0	TGF-b-activated_kinase_1	0,24	Cdo	119,122	TGF-b-activated kinase 1	Cdo	26409(Tax:10090)	12583(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	TGF-b-activated_kinase_1 -LRB- TAK1 -RRB- and apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway .
24728340	0	TGF-b-activated_kinase_1	0,24	TAK1	26,30	TGF-b-activated kinase 1	TAK1	6885	6885	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	TGF-b-activated_kinase_1 -LRB- TAK1 -RRB- signaling regulates TGF-b-induced WNT-5A expression in airway smooth muscle cells via Sp1 and b-catenin .
21359495	0	TGF-b1	0,6	ADAM17	80,86	TGF-b1	ADAM17	7040	6868	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	TGF-b1 promotes motility and invasiveness of glioma cells through activation of ADAM17 .
24588264	0	TGF-b1	69,75	AngII	87,92	TGF-b1	AngII	21803(Tax:10090)	11606(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The Ang - -LRB- 1-7 -RRB- / Mas-1 axis attenuates the expression and signalling of TGF-b1 induced by AngII in mouse skeletal muscle .
25748499	0	TGF-b1	57,63	Apelin	0,6	TGF-b1	Apelin	59086(Tax:10116)	58812(Tax:10116)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Apelin protects against acute_renal_injury by inhibiting TGF-b1 .
26447026	0	TGF-b1	93,99	BMP-2	87,92	TGF-b1	BMP-2	7040	650	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	The effect of low-level diode laser therapy on early differentiation of osteoblast via BMP-2 / TGF-b1 and its receptors .
26022109	0	TGF-b1	46,52	BRCA1	0,5	TGF-b1	BRCA1	7040	672	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
26022109	0	TGF-b1	46,52	BRCA1	0,5	TGF-b1	BRCA1	7040	672	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
20721606	0	TGF-b1	100,106	C-type_natriuretic_peptide	25,51	TGF-b1	C-type natriuretic peptide	7040	4880	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Dose dependent effect of C-type_natriuretic_peptide signaling in glycosaminoglycan synthesis during TGF-b1 induced chondrogenic differentiation of mesenchymal stem cells .
22714108	0	TGF-b1	120,126	C-type_natriuretic_peptide-3	15,43	TGF-b1	C-type natriuretic peptide-3	100873157	419487(Tax:9031)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Implication of C-type_natriuretic_peptide-3 signaling in glycosaminoglycan synthesis and chondrocyte hypertrophy during TGF-b1 induced chondrogenic differentiation of chicken bone marrow-derived mesenchymal stem cells .
26340021	0	TGF-b1	40,46	CCN2	51,55	TGF-b1	CCN2	21803(Tax:10090)	14219(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Induction Induction|compound|END_ENTITY	AFAP1 Is a Novel Downstream Mediator of TGF-b1 for CCN2 Induction in Osteoblasts .
25973094	0	TGF-b1	123,129	CD14	15,19	TGF-b1	CD14	7040	929	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CD14 and TLR4 with LPS-stimulated human normal skin fibroblasts in immunophenotype changes and secretion of TGF-b1 and IFN-y .
22749982	0	TGF-b1	37,43	CD25	66,70	TGF-b1	CD25	7040	3559	Gene	Gene	CD152|appos|START_ENTITY Induction|nmod|CD152 Induction|dep|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
24904415	0	TGF-b1	119,125	CD25	4,8	TGF-b1	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	exposed|amod|START_ENTITY lung|amod|exposed production|nmod|lung suppression|nmod|production recruitment|nmod|suppression inhibit|dobj|recruitment inhibit|nsubj|Tregs Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
22749982	0	TGF-b1	37,43	CD4	61,64	TGF-b1	CD4	7040	920	Gene	Gene	CD152|appos|START_ENTITY Induction|nmod|CD152 Induction|dep|CD25 CD25|compound|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
24904415	0	TGF-b1	119,125	CD4	0,3	TGF-b1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	exposed|amod|START_ENTITY lung|amod|exposed production|nmod|lung suppression|nmod|production recruitment|nmod|suppression inhibit|dobj|recruitment inhibit|nsubj|Tregs Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
24098479	0	TGF-b1	0,6	COX-2	21,26	TGF-b1	COX-2	7040	5743	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	TGF-b1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung_cancer A549 cells , which is involved in fibrotic response to TGF-b1 .
24098479	0	TGF-b1	152,158	COX-2	21,26	TGF-b1	COX-2	7040	5743	Gene	Gene	involved|nmod|START_ENTITY cells|acl:relcl|involved decrease|nmod|cells leading|xcomp|decrease expression|acl|leading expression|compound|END_ENTITY	TGF-b1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung_cancer A549 cells , which is involved in fibrotic response to TGF-b1 .
24712567	0	TGF-b1	0,6	COX-2	15,20	TGF-b1	COX-2	7040	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TGF-b1 induces COX-2 expression and PGE2 production in human granulosa cells through Smad signaling pathways .
25138701	0	TGF-b1	0,6	CXCR4	113,118	TGF-b1	CXCR4	7040	7852	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	TGF-b1 enhances SDF-1-induced migration and tube formation of choroid-retinal endothelial cells by up-regulating CXCR4 and CXCR7 expression .
21641995	0	TGF-b1	21,27	Caveolin-1	0,10	TGF-b1	Caveolin-1	21803(Tax:10090)	12389(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Caveolin-1 modulates TGF-b1 signaling in cardiac_remodeling .
25955392	0	TGF-b1	0,6	Connective_Tissue_Growth_Factor	20,51	TGF-b1	Connective Tissue Growth Factor	7040	1490	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b1 Up-Regulates Connective_Tissue_Growth_Factor Expression in Human Granulosa Cells through Smad and ERK1/2 Signaling Pathways .
26275398	0	TGF-b1	125,131	Connexin43	92,102	TGF-b1	Connexin43	59086(Tax:10116)	24392(Tax:10116)	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-b1 / Smads Signaling in a Rat Model of Myocardial_Infarction .
25531329	0	TGF-b1	66,72	DRAK1	12,17	TGF-b1	DRAK1	7040	9263	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
25903025	0	TGF-b1	44,50	Decorin	27,34	TGF-b1	Decorin	7040	1634	Gene	Gene	START_ENTITY|nsubj|Inhibits Inhibits|compound|END_ENTITY	Recombinant Human Decorin Inhibits TGF-b1 Induced Contraction of Collagen Lattice by Keloid Fibroblasts .
23373709	0	TGF-b1	54,60	ERK	61,64	TGF-b1	ERK	59086(Tax:10116)	24338(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|parataxis|signaling signaling|nsubj|END_ENTITY	The effects of qindan-capsule-containing serum on the TGF-b1 / ERK signaling pathway , matrix metalloproteinase synthesis and cell function in adventitial fibroblasts .
25224321	0	TGF-b1	35,41	Egr-1	101,106	TGF-b1	Egr-1	7040	1958	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of increased levels of TGF-b1 and p14ARF in prostate_carcinoma cell lines overexpressing Egr-1 .
20878063	0	TGF-b1	58,64	Endoglin	23,31	TGF-b1	Endoglin	7040	2022	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of Endoglin and its receptor complex -LRB- TGF-b1 and TGF-b_receptor_II -RRB- as early angiogenic switch indicator in premalignant_lesions_of_the_colon_mucosa .
25375657	0	TGF-b1	27,33	FOSL2	0,5	TGF-b1	FOSL2	7040	2355	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	FOSL2 positively regulates TGF-b1 signalling in non-small_cell_lung_cancer .
25674226	0	TGF-b1	86,92	FOXO1	61,66	TGF-b1	FOXO1	21803(Tax:10090)	56458(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Dehydroabietic_acid reverses TNF-a-induced the activation of FOXO1 and suppression of TGF-b1 / Smad signaling in human adult dermal fibroblasts .
25287361	0	TGF-b1	31,37	FOXQ1	16,21	TGF-b1	FOXQ1	7040	94234	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Forkhead factor FOXQ1 promotes TGF-b1 expression and induces epithelial-mesenchymal transition .
24904415	0	TGF-b1	119,125	FoxP3	9,14	TGF-b1	FoxP3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	exposed|amod|START_ENTITY lung|amod|exposed production|nmod|lung suppression|nmod|production recruitment|nmod|suppression inhibit|dobj|recruitment inhibit|nsubj|Tregs Tregs|compound|END_ENTITY	CD4 + CD25 + FoxP3 + Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-b1 exposed murine lung .
26264613	0	TGF-b1	86,92	FoxP3	0,5	TGF-b1	FoxP3	7040	50943	Gene	Gene	repression|nmod|START_ENTITY END_ENTITY|nsubj|repression	FoxP3 in papillary_thyroid_carcinoma induces NIS repression through activation of the TGF-b1 / Smad signaling pathway .
21528082	0	TGF-b1	90,96	Foxp3	38,43	TGF-b1	Foxp3	7040	50943	Gene	Gene	production|nmod|START_ENTITY induce|nmod|production induce|dobj|cells cells|amod|END_ENTITY	Gastric_cancer cells induce human CD4 + Foxp3 + regulatory T cells through the production of TGF-b1 .
21779356	0	TGF-b1	15,21	Foxp3	41,46	TGF-b1	Foxp3	7040	50943	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	IL-1b promotes TGF-b1 and IL-2 dependent Foxp3 expression in regulatory T cells .
22161558	0	TGF-b1	125,131	Foxp3	74,79	TGF-b1	Foxp3	7040	50943	Gene	Gene	pathway|compound|START_ENTITY regulate|nmod|pathway regulate|dobj|expression expression|amod|END_ENTITY	Hypothesis : human umbilical cord blood-derived stromal cells regulate the Foxp3 expression of regulatory T cells through the TGF-b1 / Smad3 pathway .
22270834	0	TGF-b1	21,27	Foxp3	121,126	TGF-b1	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Dendritic cells with TGF-b1 and IL-2 differentiate naive CD4 + T cells into alloantigen-specific and allograft protective Foxp3 + regulatory T cells .
22749982	0	TGF-b1	37,43	Foxp3	54,59	TGF-b1	Foxp3	7040	50943	Gene	Gene	CD152|appos|START_ENTITY Induction|nmod|CD152 Induction|nmod|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
23361571	0	TGF-b1	0,6	Foxp3	74,79	TGF-b1	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	TGF-b1 secreted by hepatocellular_carcinoma induces the expression of the Foxp3 gene and suppresses antitumor immunity in the tumor microenvironment .
24668348	0	TGF-b1	130,136	Foxp3	57,62	TGF-b1	Foxp3	7040	50943	Gene	Gene	response|nmod|START_ENTITY T|dobj|response T|nsubj|suppresses suppresses|amod|END_ENTITY	Human hepatocellular_carcinoma-infiltrating CD4 CD69 Foxp3 regulatory T cell suppresses T cell response via membrane-bound TGF-b1 .
25127859	0	TGF-b1	41,47	GARP	48,52	TGF-b1	GARP	21803(Tax:10090)	235505(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Release of active TGF-b1 from the latent TGF-b1 / GARP complex on T regulatory cells is mediated by integrin_b8 .
22859956	0	TGF-b1	15,21	GLI2	0,4	TGF-b1	GLI2	7040	2736	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GLI2 regulates TGF-b1 in human CD4 + T cells : implications in cancer and HIV pathogenesis .
24258001	0	TGF-b1	26,32	GM-CSF	16,22	TGF-b1	GM-CSF	7040	1437	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of GM-CSF by TGF-b1 in epithelial mesenchymal transition of human HERS/ERM cells .
26022109	0	TGF-b1	46,52	Gadd45a	72,79	TGF-b1	Gadd45a	7040	1647	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
26022109	0	TGF-b1	46,52	Gadd45a	72,79	TGF-b1	Gadd45a	7040	1647	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
26417995	0	TGF-b1	64,70	H19	20,23	TGF-b1	H19	7040	283120	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	Long Non-Coding RNA H19 Promotes Osteoblast Differentiation via TGF-b1 / Smad3/HDAC Signaling 0050athway by Deriving miR-675 .
22718393	0	TGF-b1	32,38	HGF	0,3	TGF-b1	HGF	59086(Tax:10116)	24446(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	HGF regulates the activation of TGF-b1 in rat hepatocytes and hepatic stellate cells .
25572132	0	TGF-b1	0,6	HMGA1	15,20	TGF-b1	HMGA1	7040	3159	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	TGF-b1 induces HMGA1 expression in human breast_cancer cells : Implications of the involvement of HMGA1 in TGF-b signaling .
25726184	0	TGF-b1	89,95	HtrA1	0,5	TGF-b1	HtrA1	7040	5654	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	HtrA1 may regulate the osteogenic differentiation of human periodontal ligament cells by TGF-b1 .
21343678	0	TGF-b1	40,46	ICAM-1	18,24	TGF-b1	ICAM-1	7040	3383	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	Radiation-induced ICAM-1 expression via TGF-b1 pathway on human umbilical vein endothelial cells ; comparison between X-ray and carbon-ion beam irradiation .
22573330	0	TGF-b1	106,112	IGF-1	44,49	TGF-b1	IGF-1	7040	3479	Gene	Gene	administration|appos|START_ENTITY expression|nmod|administration expression|appos|END_ENTITY	Inhibition of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- expression by prolonged transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- administration suppresses osteoblast differentiation .
22579999	0	TGF-b1	28,34	IGF-1	14,19	TGF-b1	IGF-1	7040	3479	Gene	Gene	Regulation|amod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of IGF-1 but not TGF-b1 by NGF in the smooth muscle of the inflamed urinary bladder .
20553076	0	TGF-b1	77,83	IGF-I	53,58	TGF-b1	IGF-I	7040	3479	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Associations of food and nutrient intakes with serum IGF-I , IGF-II , IGFBP-3 , TGF-b1 , total SOD activity and sFas levels among middle-aged Japanese : the Japan Collaborative Cohort study .
24819026	0	TGF-b1	73,79	IL-10	66,71	TGF-b1	IL-10	7040	3586	Gene	Gene	IFN-y|dep|START_ENTITY IFN-y|dep|END_ENTITY	Prognostic importance of single-nucleotide polymorphisms in IL-6 , IL-10 , TGF-b1 , IFN-y , and TNF-a genes in chronic_phase_chronic_myeloid_leukemia .
24974875	0	TGF-b1	22,28	IL-10	30,35	TGF-b1	IL-10	7040	3586	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Association of TNF-a , TGF-b1 , IL-10 , IL-6 , and IFN-y gene polymorphism with acute rejection and infection in lung transplant recipients .
21722622	0	TGF-b1	8,14	IL-1b	28,33	TGF-b1	IL-1b	282089(Tax:9913)	281251(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|compound|END_ENTITY	Role of TGF-b1 and TNF-a in IL-1b mediated activation of proMMP-9 in pulmonary artery smooth muscle cells : involvement of an aprotinin sensitive protease .
21779356	0	TGF-b1	15,21	IL-1b	0,5	TGF-b1	IL-1b	7040	3553	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	IL-1b promotes TGF-b1 and IL-2 dependent Foxp3 expression in regulatory T cells .
23696858	0	TGF-b1	101,107	IL-1b	52,57	TGF-b1	IL-1b	59086(Tax:10116)	24494(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	HMGB1 accelerates alveolar epithelial repair via an IL-1b - and avb6 integrin-dependent activation of TGF-b1 .
24819026	0	TGF-b1	73,79	IL-6	60,64	TGF-b1	IL-6	7040	3569	Gene	Gene	IFN-y|dep|START_ENTITY IFN-y|compound|END_ENTITY	Prognostic importance of single-nucleotide polymorphisms in IL-6 , IL-10 , TGF-b1 , IFN-y , and TNF-a genes in chronic_phase_chronic_myeloid_leukemia .
21150927	0	TGF-b1	39,45	Integrin-linked_kinase	0,22	TGF-b1	Integrin-linked kinase	7040	3611	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	Integrin-linked_kinase is required for TGF-b1 induction of dermal myofibroblast differentiation .
26126825	0	TGF-b1	66,72	Lysosomal-Associated_Transmembrane_Protein_4B	0,45	TGF-b1	Lysosomal-Associated Transmembrane Protein 4B	7040	55353	Gene	Gene	Production|compound|START_ENTITY Decreases|dobj|Production Decreases|nsubj|END_ENTITY	Lysosomal-Associated_Transmembrane_Protein_4B -LRB- LAPTM4B -RRB- Decreases TGF-b1 Production in Human Regulatory T Cells .
24291552	0	TGF-b1	32,38	MCP-1	47,52	TGF-b1	MCP-1	7040	6347	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|compound|END_ENTITY	Inhibition of KCa3 .1 suppresses TGF-b1 induced MCP-1 expression in human proximal tubular cells through Smad3 , p38 and ERK1/2 signaling pathways .
23449457	0	TGF-b1	0,6	MKP-1	43,48	TGF-b1	MKP-1	7040	1843	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	TGF-b1 and hypoxia-dependent expression of MKP-1 leads tumor resistance to death receptor-mediated cell death .
26422857	0	TGF-b1	32,38	MMP-1	18,23	TGF-b1	MMP-1	7040	4312	Gene	Gene	PDGF-AB|dep|START_ENTITY PDGF-AB|compound|END_ENTITY	Evaluation of GCF MMP-1 , MMP-8 , TGF-b1 , PDGF-AB , and VEGF levels in periodontally healthy smokers .
21219858	0	TGF-b1	0,6	MMP-2	74,79	TGF-b1	MMP-2	7040	4313	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	TGF-b1 increases invasiveness of SW1990 cells through Rac1/ROS/NF-kB / IL-6 / MMP-2 .
26748386	0	TGF-b1	17,23	MiR-23b	0,7	TGF-b1	MiR-23b	7040	407011	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	MiR-23b controls TGF-b1 induced airway_smooth_muscle cell proliferation via TGFbR2/p-Smad 3 signals .
26383248	0	TGF-b1	54,60	MicroRNA-21	0,11	TGF-b1	MicroRNA-21	7040	406991	Gene	Gene	Cells|nmod|START_ENTITY Cells|compound|END_ENTITY	MicroRNA-21 Negatively Regulates Treg Cells Through a TGF-b1 / Smad-Independent Pathway in Patients with Coronary_Heart_Disease .
24987792	0	TGF-b1	91,97	PAI-1	70,75	TGF-b1	PAI-1	7040	5054	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Cross-talk Between Human Mast Cells and Bronchial Epithelial Cells in PAI-1 Production via TGF-b1 .
25787292	0	TGF-b1	114,120	PTEN	96,100	TGF-b1	PTEN	7040	5728	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	High concentrations of uric acid inhibit endothelial cell migration via miR-663 which regulates PTEN by targeting TGF-b1 .
26796257	0	TGF-b1	0,6	PTEN	85,89	TGF-b1	PTEN	7040	5728	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	TGF-b1 induces erlotinib resistance in non-small_cell_lung_cancer by down-regulating PTEN .
26275398	0	TGF-b1	125,131	Peroxisome_Proliferator-Activated_Receptor_Gamma	0,48	TGF-b1	Peroxisome Proliferator-Activated Receptor Gamma	59086(Tax:10116)	25664(Tax:10116)	Gene	Gene	Cells|nmod|START_ENTITY Cells|compound|END_ENTITY	Peroxisome_Proliferator-Activated_Receptor_Gamma Promotes Mesenchymal Stem Cells to Express Connexin43 via the Inhibition of TGF-b1 / Smads Signaling in a Rat Model of Myocardial_Infarction .
24530597	0	TGF-b1	54,60	Pin1	0,4	TGF-b1	Pin1	21803(Tax:10090)	23988(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Pin1 induction in the fibrotic liver and its roles in TGF-b1 expression and Smad2/3 phosphorylation .
25974964	0	TGF-b1	82,88	RBP2	20,24	TGF-b1	RBP2	7040	5948	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Histone demethylase RBP2 promotes malignant progression of gastric_cancer through TGF-b1 - -LRB- p-Smad3 -RRB- - RBP2-E-cadherin-Smad3 feedback circuit .
26785300	0	TGF-b1	88,94	ROCK1	95,100	TGF-b1	ROCK1	59086(Tax:10116)	81762(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|pathway pathway|nummod|END_ENTITY	Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-b1 / ROCK1 pathway in silicosis in rat .
26622610	0	TGF-b1	21,27	RhoC	0,4	TGF-b1	RhoC	7040	389	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	RhoC is essential in TGF-b1 induced epithelial-mesenchymal transition in cervical cancer cells .
24809782	0	TGF-b1	28,34	SERPINB3	0,8	TGF-b1	SERPINB3	7040	6317	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	SERPINB3 is associated with TGF-b1 and cytoplasmic b-catenin expression in hepatocellular_carcinomas with poor prognosis .
25954931	0	TGF-b1	70,76	SERT	48,52	TGF-b1	SERT	7040	6532	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Mechanisms of Intestinal Serotonin_Transporter -LRB- SERT -RRB- Upregulation by TGF-b1 Induced Non-Smad Pathways .
23057634	0	TGF-b1	44,50	SHP2	29,33	TGF-b1	SHP2	21803(Tax:10090)	19247(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Protein tyrosine phosphatase SHP2 regulates TGF-b1 production in airway epithelia and asthmatic airway remodeling in mice .
23541743	0	TGF-b1	104,110	SMAD3	111,116	TGF-b1	SMAD3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY effect|nmod|inhibition effect|parataxis|END_ENTITY	The effect of curcumin on sepsis-induced acute_lung_injury in a rat model through the inhibition of the TGF-b1 / SMAD3 pathway .
23576639	0	TGF-b1	41,47	SMAD3	98,103	TGF-b1	SMAD3	7040	4088	Gene	Gene	antagonism|nmod|START_ENTITY defines|nsubj|antagonism defines|dobj|fluctuations fluctuations|nmod|activity activity|nummod|END_ENTITY	Notch4-dependent antagonism of canonical TGF-b1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells .
25954931	0	TGF-b1	70,76	Serotonin_Transporter	25,46	TGF-b1	Serotonin Transporter	7040	6532	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|compound|END_ENTITY	Mechanisms of Intestinal Serotonin_Transporter -LRB- SERT -RRB- Upregulation by TGF-b1 Induced Non-Smad Pathways .
22139024	0	TGF-b1	0,6	Smad2	53,58	TGF-b1	Smad2	7040	4087	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|activating activating|dobj|pathway pathway|amod|END_ENTITY	TGF-b1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal_carcinomatosis .
24688224	0	TGF-b1	30,36	Smad2	37,42	TGF-b1	Smad2	21803(Tax:10090)	17126(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|parataxis|signaling signaling|nsubj|END_ENTITY	Early activation of pulmonary TGF-b1 / Smad2 signaling in mice with acute_pancreatitis-associated acute_lung_injury .
24928277	0	TGF-b1	27,33	Smad2	94,99	TGF-b1	Smad2	7040	4087	Gene	Gene	galectin-1|nmod|START_ENTITY Induction|nmod|galectin-1 accelerates|nsubj|Induction accelerates|advcl|enhancing enhancing|dobj|retention retention|nmod|END_ENTITY	Induction of galectin-1 by TGF-b1 accelerates fibrosis through enhancing nuclear retention of Smad2 .
25351340	0	TGF-b1	23,29	Smad2	0,5	TGF-b1	Smad2	7040	4087	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Smad2 protects against TGF-b1 / Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic_fibrosis .
25891879	0	TGF-b1	121,127	Smad2	128,133	TGF-b1	Smad2	7040	4087	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	AST inhibits H2O2-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-b1 / Smad2 pathway .
25041068	0	TGF-b1	92,98	Smad2/3	99,106	TGF-b1	Smad2/3	21803(Tax:10090)	17126;17127	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-b1 / Smad2/3 signalling .
27061332	0	TGF-b1	12,18	Smad2/3	19,26	TGF-b1	Smad2/3	100008645(Tax:9986)	100359137;100346303	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|amod|END_ENTITY	The role of TGF-b1 / Smad2/3 pathway in platelet-rich plasma in retarding intervertebral_disc_degeneration .
27067480	0	TGF-b1	189,195	Smad2/3	10,17	TGF-b1	Smad2/3	21803(Tax:10090)	17126;17127	Gene	Gene	activation|nmod|START_ENTITY Evidence|nmod|activation phosphorylation|dep|Evidence phosphorylation|amod|END_ENTITY	Increased Smad2/3 phosphorylation in circulating leukocytes and platelet-leukocyte aggregates in a mouse model of aortic_valve_stenosis : Evidence of systemic activation of platelet-derived TGF-b1 and correlation with cardiac_dysfunction .
21354414	0	TGF-b1	63,69	Smad3	70,75	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY contribute|nmod|activation contribute|dobj|END_ENTITY	Down-regulation of miR-23b may contribute to activation of the TGF-b1 / Smad3 signalling pathway during the termination stage of liver regeneration .
22161558	0	TGF-b1	125,131	Smad3	132,137	TGF-b1	Smad3	7040	4088	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Hypothesis : human umbilical cord blood-derived stromal cells regulate the Foxp3 expression of regulatory T cells through the TGF-b1 / Smad3 pathway .
23091366	0	TGF-b1	8,14	Smad3	15,20	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|signaling signaling|nsubj|END_ENTITY	Role of TGF-b1 / Smad3 signaling pathway in secretion of type I and III collagen by vascular smooth muscle cells of rats undergoing balloon_injury .
23967091	0	TGF-b1	66,72	Smad3	73,78	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Low-dose paclitaxel ameliorates pulmonary_fibrosis by suppressing TGF-b1 / Smad3 pathway via miR-140 upregulation .
24042439	0	TGF-b1	89,95	Smad3	96,101	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	downregulating|dobj|START_ENTITY lung_fibrosis|acl|downregulating lung_fibrosis|parataxis|signaling signaling|nsubj|END_ENTITY	All-transretinoic_acid ameliorates bleomycin-induced lung_fibrosis by downregulating the TGF-b1 / Smad3 signaling pathway in rats .
24291552	0	TGF-b1	32,38	Smad3	104,109	TGF-b1	Smad3	7040	4088	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Inhibition of KCa3 .1 suppresses TGF-b1 induced MCP-1 expression in human proximal tubular cells through Smad3 , p38 and ERK1/2 signaling pathways .
24839113	0	TGF-b1	110,116	Smad3	117,122	TGF-b1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Unloading|nmod|Activation Muscles|nmod|Unloading Involved|nmod|Muscles Involved|dep|Signaling Signaling|compound|END_ENTITY	Dystrophin Involved in the Susceptibility of Slow Muscles to Hindlimb Unloading via Concomitant Activation of TGF-b1 / Smad3 Signaling and Ubiquitin-Proteasome Degradation in Mice .
25140399	0	TGF-b1	0,6	Smad3	83,88	TGF-b1	Smad3	7040	4088	Gene	Gene	Expression|compound|START_ENTITY Pathways|nsubj|Expression Pathways|nmod|END_ENTITY	TGF-b1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells .
25406285	0	TGF-b1	99,105	Smad3	106,111	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	Fibrosis|nmod|START_ENTITY Fibrosis|parataxis|Pathway Pathway|compound|END_ENTITY	Benzalkonium_Chloride Induces Subconjunctival Fibrosis Through the COX-2-Modulated Activation of a TGF-b1 / Smad3 Signaling Pathway .
25531329	0	TGF-b1	66,72	Smad3	113,118	TGF-b1	Smad3	7040	4088	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nmod|binding binding|nmod|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
25674210	0	TGF-b1	60,66	Smad3	67,72	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	growth|nmod|START_ENTITY growth|dep|pathway pathway|amod|END_ENTITY	Chitosan inhibits fibroblasts growth in Achilles tendon via TGF-b1 / Smad3 pathway by miR-29b .
26012254	0	TGF-b1	74,80	Smad3	81,86	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	rats|nmod|START_ENTITY alleviates|nmod|rats alleviates|parataxis|signaling signaling|nsubj|END_ENTITY	Triptolide alleviates isoprenaline-induced cardiac_remodeling in rats via TGF-b1 / Smad3 and p38_MAPK signaling pathway .
26045780	0	TGF-b1	138,144	Smad3	145,150	TGF-b1	Smad3	7040	4088	Gene	Gene	blocking|dobj|START_ENTITY cells|acl|blocking transition|nmod|cells mesenchymal|dobj|transition epithelial|xcomp|mesenchymal reverses|xcomp|epithelial inhibitor|acl:relcl|reverses inhibitor|parataxis|signaling signaling|nsubj|END_ENTITY	Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-b1 / Smad3 signaling pathway in vitro .
26487518	0	TGF-b1	82,88	Smad3	89,94	TGF-b1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	Cardiac_Fibrosis|nmod|START_ENTITY Cardiac_Fibrosis|parataxis|Pathway Pathway|compound|END_ENTITY	Notch3 Ameliorates Cardiac_Fibrosis After Myocardial_Infarction by Inhibiting the TGF-b1 / Smad3 Pathway .
26551763	0	TGF-b1	116,122	Smad3	123,128	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	Downregulating|dep|START_ENTITY Downregulating|dep|END_ENTITY	Protective Effect of Zingiber Officinale against CCl4-Induced Liver_Fibrosis Is Mediated through Downregulating the TGF-b1 / Smad3 and NF-x03BA ; B/Ix03BA ; B Pathways .
26604970	0	TGF-b1	104,110	Smad3	111,116	TGF-b1	Smad3	7040	4088	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Beneficial Effects of Qili Qiangxin Capsule on Lung Structural Remodeling in Ischemic_Heart_Failure via TGF-b1 / Smad3 Pathway .
26959841	0	TGF-b1	110,116	Smad3	117,122	TGF-b1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|parataxis|signaling signaling|nsubj|END_ENTITY	Fenofibrate attenuates diabetic_nephropathy in experimental diabetic rat 's model via suppression of augmented TGF-b1 / Smad3 signaling pathway .
21726607	0	TGF-b1	0,6	Smad4	85,90	TGF-b1	Smad4	7040	4089	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	TGF-b1 inhibits the growth and metastasis of tongue squamous_carcinoma cells through Smad4 .
22028478	0	TGF-b1	86,92	Smad4	42,47	TGF-b1	Smad4	7040	4089	Gene	Gene	stimulation|compound|START_ENTITY sensitivity|nmod|stimulation contributes|nmod|sensitivity contributes|nsubj|down-regulation down-regulation|nmod|END_ENTITY	MicroRNA-130a-mediated down-regulation of Smad4 contributes to reduced sensitivity to TGF-b1 stimulation in granulocytic precursors .
25531329	0	TGF-b1	66,72	Smad4	159,164	TGF-b1	Smad4	7040	4089	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nmod|binding binding|acl|interrupt interrupt|nmod|END_ENTITY	Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-b1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4 .
26022109	0	TGF-b1	46,52	Smad4	118,123	TGF-b1	Smad4	7040	4089	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|enhancing enhancing|dobj|stability stability|nmod|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
26022109	0	TGF-b1	46,52	Smad4	118,123	TGF-b1	Smad4	7040	4089	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|enhancing enhancing|dobj|stability stability|nmod|END_ENTITY	BRCA1 regulates transforming_growth_factor-b -LRB- TGF-b1 -RRB- signaling through Gadd45a by enhancing the protein stability of Smad4 .
24096742	0	TGF-b1	29,35	Smad6	0,5	TGF-b1	Smad6	21803(Tax:10090)	17130(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Smad6 inhibits non-canonical TGF-b1 signalling by recruiting the deubiquitinase A20 to TRAF6 .
25140399	0	TGF-b1	0,6	StAR	21,25	TGF-b1	StAR	7040	6770	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TGF-b1 Downregulates StAR Expression and Decreases Progesterone Production Through Smad3 and ERK1/2 Signaling Pathways in Human Granulosa Cells .
20955806	0	TGF-b1	11,17	Superficial_Zone_Protein	45,69	TGF-b1	Superficial Zone Protein	7040	10216	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of TGF-b1 on alternative splicing of Superficial_Zone_Protein in articular cartilage cultures .
23685990	0	TGF-b1	27,33	Surfactant_protein_A	0,20	TGF-b1	Surfactant protein A	7040	653509	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Surfactant_protein_A binds TGF-b1 with high affinity and stimulates the TGF-b pathway .
24025717	0	TGF-b1	62,68	TBX3	14,18	TGF-b1	TBX3	7040	6926	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The oncogenic TBX3 is a downstream target and mediator of the TGF-b1 signaling pathway .
25158279	0	TGF-b1	29,35	TBX3	0,4	TGF-b1	TBX3	7040	6926	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	TBX3 , a downstream target of TGF-b1 , inhibits mesangial cell apoptosis .
25371204	0	TGF-b1	39,45	TBX3	127,131	TGF-b1	TBX3	7040	6926	Gene	Gene	Pathway|compound|START_ENTITY Function|nmod|Pathway Involves|nsubj|Function Involves|nmod|END_ENTITY	The Anti-proliferative Function of the TGF-b1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3 .
26498464	0	TGF-b1	19,25	TGF-b	27,32	TGF-b1	TGF-b	7040	7040	Gene	Gene	receptor|compound|START_ENTITY receptor|dep|END_ENTITY	Down-regulation of TGF-b1 , TGF-b receptor 2 , and TGF-b-associated microRNAs , miR-20a and miR-21 , in skin_lesions of sulfur mustard-exposed Iranian war veterans .
25127859	0	TGF-b1	18,24	TGF-b1	41,47	TGF-b1	TGF-b1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Release of active TGF-b1 from the latent TGF-b1 / GARP complex on T regulatory cells is mediated by integrin_b8 .
25127859	0	TGF-b1	41,47	TGF-b1	18,24	TGF-b1	TGF-b1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Release of active TGF-b1 from the latent TGF-b1 / GARP complex on T regulatory cells is mediated by integrin_b8 .
26246140	0	TGF-b1	54,60	TGF-b1	94,100	TGF-b1	TGF-b1	7040	7040	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Hepatic Stellate Cells Inhibit T Cells through Active TGF-b1 from a Cell Surface-Bound Latent TGF-b1 / GARP Complex .
26246140	0	TGF-b1	54,60	TGF-b1	94,100	TGF-b1	TGF-b1	7040	7040	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Hepatic Stellate Cells Inhibit T Cells through Active TGF-b1 from a Cell Surface-Bound Latent TGF-b1 / GARP Complex .
26246140	0	TGF-b1	94,100	TGF-b1	54,60	TGF-b1	TGF-b1	7040	7040	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Hepatic Stellate Cells Inhibit T Cells through Active TGF-b1 from a Cell Surface-Bound Latent TGF-b1 / GARP Complex .
26246140	0	TGF-b1	94,100	TGF-b1	54,60	TGF-b1	TGF-b1	7040	7040	Gene	Gene	Cells|nmod|START_ENTITY Cells|nmod|END_ENTITY	Hepatic Stellate Cells Inhibit T Cells through Active TGF-b1 from a Cell Surface-Bound Latent TGF-b1 / GARP Complex .
24211974	0	TGF-b1	83,89	TLR4	0,4	TGF-b1	TLR4	21803(Tax:10090)	21898(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	TLR4 signaling pathway in mouse Lewis lung_cancer cells promotes the expression of TGF-b1 and IL-10 and tumor cells migration .
24974875	0	TGF-b1	22,28	TNF-a	15,20	TGF-b1	TNF-a	7040	7124	Gene	Gene	IL-6|dep|START_ENTITY IL-6|amod|END_ENTITY	Association of TNF-a , TGF-b1 , IL-10 , IL-6 , and IFN-y gene polymorphism with acute rejection and infection in lung transplant recipients .
25633840	0	TGF-b1	0,6	TP53INP1	45,53	TGF-b1	TP53INP1	7040	94241	Gene	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	TGF-b1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes .
26738569	0	TGF-b1	0,6	Triggering_Receptor_Expressed_on_Myeloid_Cells_1	37,85	TGF-b1	Triggering Receptor Expressed on Myeloid Cells 1	21803(Tax:10090)	58217(Tax:10090)	Gene	Gene	Upregulates|nsubj|START_ENTITY Upregulates|dobj|Expression Expression|nmod|END_ENTITY	TGF-b1 Upregulates the Expression of Triggering_Receptor_Expressed_on_Myeloid_Cells_1 in Murine Lungs .
22995554	0	TGF-b1	47,53	Tsukushi	0,8	TGF-b1	Tsukushi	7040	25987	Gene	Gene	regulating|dobj|START_ENTITY controls|advcl|regulating controls|nsubj|END_ENTITY	Tsukushi controls the hair cycle by regulating TGF-b1 signaling .
26657209	0	TGF-b1	55,61	URG-4	74,79	TGF-b1	URG-4	7040	55665	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Identification of intracellular pathways through which TGF-b1 upregulates URG-4 / URGCP gene expression in hepatoma cells .
26657209	0	TGF-b1	55,61	URGCP	80,85	TGF-b1	URGCP	7040	55665	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Identification of intracellular pathways through which TGF-b1 upregulates URG-4 / URGCP gene expression in hepatoma cells .
21057546	0	TGF-b1	58,64	VEGF	40,44	TGF-b1	VEGF	7040	7422	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|functions functions|nmod|isoforms isoforms|nmod|END_ENTITY	Opposite functions of HIF-a isoforms in VEGF induction by TGF-b1 under non-hypoxic conditions .
22522454	0	TGF-b1	0,6	VEGF	54,58	TGF-b1	VEGF	7040	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|shifting shifting|dobj|activation activation|compound|END_ENTITY	TGF-b1 induces endothelial cell apoptosis by shifting VEGF activation of p38 -LRB- MAPK -RRB- from the prosurvival p38b to proapoptotic p38a .
23684430	0	TGF-b1	13,19	VEGF	0,4	TGF-b1	VEGF	100008645(Tax:9986)	100008899(Tax:9986)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	VEGF induces TGF-b1 expression and myofibroblast transformation after glaucoma surgery .
26577912	0	TGF-b1	45,51	VEGF-A	11,17	TGF-b1	VEGF-A	7040	7422	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Peritoneal VEGF-A expression is regulated by TGF-b1 through an ID1 pathway in women with endometriosis .
25818166	0	TGF-b1	38,44	ZEB2	0,4	TGF-b1	ZEB2	7040	9839	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	ZEB2 promotes vasculogenic_mimicry by TGF-b1 induced epithelial-to-mesenchymal transition in hepatocellular_carcinoma .
24085277	0	TGF-b1	99,105	ank	47,50	TGF-b1	ank	7040	286	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Continuous cyclic mechanical tension increases ank expression in endplate chondrocytes through the TGF-b1 and p38 pathway .
20843298	0	TGF-b1	51,57	b-Catenin	0,9	TGF-b1	b-Catenin	7040	1499	Gene	Gene	targets|nmod|START_ENTITY GTPases|nmod|targets GTPases|nsubj|END_ENTITY	b-Catenin and Rho GTPases as downstream targets of TGF-b1 during pulp repair .
22706027	0	TGF-b1	34,40	b-Catenin	0,9	TGF-b1	b-Catenin	7040	1499	Gene	Gene	inhibition|compound|START_ENTITY required|nmod|inhibition required|nsubjpass|pathway pathway|amod|END_ENTITY	b-Catenin pathway is required for TGF-b1 inhibition of PPARy expression in cultured hepatic stellate cells .
24809782	0	TGF-b1	28,34	b-catenin	51,60	TGF-b1	b-catenin	7040	1499	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	SERPINB3 is associated with TGF-b1 and cytoplasmic b-catenin expression in hepatocellular_carcinomas with poor prognosis .
21251385	0	TGF-b1	12,18	connective_tissue_growth_factor	41,72	TGF-b1	connective tissue growth factor	59086(Tax:10116)	64032(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of TGF-b1 on gene expression of connective_tissue_growth_factor in lung fibroblasts -RSB- .
22539964	0	TGF-b1	80,86	connective_tissue_growth_factor	23,54	TGF-b1	connective tissue growth factor	7040	1490	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|acl|induction	Ets-1 is essential for connective_tissue_growth_factor -LRB- CTGF/CCN2 -RRB- induction by TGF-b1 in osteoblasts .
23824844	0	TGF-b1	54,60	connective_tissue_growth_factor	77,108	TGF-b1	connective tissue growth factor	7040	1490	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nmod|END_ENTITY	Requirement for active glycogen_synthase_kinase-3b in TGF-b1 upregulation of connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- levels in human gingival fibroblasts .
25560303	0	TGF-b1	0,6	connexin43	20,30	TGF-b1	connexin43	7040	2697	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	TGF-b1 up-regulates connexin43 expression : a potential mechanism for human trophoblast cell differentiation .
21539942	0	TGF-b1	91,97	elastin	70,77	TGF-b1	elastin	7040	2006	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Pulmonary fibroblasts from COPD patients show an impaired response of elastin synthesis to TGF-b1 .
22833091	0	TGF-b1	39,45	endoglin	120,128	TGF-b1	endoglin	7040	2022	Gene	Gene	expression|nmod|START_ENTITY predicts|nsubj|expression predicts|dobj|prognosis prognosis|acl:relcl|harbor harbor|dobj|density density|compound|END_ENTITY	High immunohistochemical expression of TGF-b1 predicts a poor prognosis in cervical_cancer patients who harbor enriched endoglin microvessel density .
23824844	0	TGF-b1	54,60	glycogen_synthase_kinase-3b	23,50	TGF-b1	glycogen synthase kinase-3b	7040	2932	Gene	Gene	upregulation|compound|START_ENTITY END_ENTITY|nmod|upregulation	Requirement for active glycogen_synthase_kinase-3b in TGF-b1 upregulation of connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- levels in human gingival fibroblasts .
21762377	0	TGF-b1	39,45	miR-145	0,7	TGF-b1	miR-145	7040	406937	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	miR-145 is differentially regulated by TGF-b1 and ischaemia and targets Disabled-2 expression and wnt/b-catenin activity .
24667864	0	TGF-b1	0,6	miR-200b	68,76	TGF-b1	miR-200b	7040	406984	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	TGF-b1 stimulates human Tenon 's capsule fibroblast proliferation by miR-200b and its targeting of p27/kip1 and RND3 .
22095944	0	TGF-b1	41,47	microRNA-29	15,26	TGF-b1	microRNA-29	7040	407021	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of microRNA-29 expression by TGF-b1 promotes collagen expression and renal_fibrosis .
21546388	0	TGF-b1	0,6	proteinase-activated_receptor_2	15,46	TGF-b1	proteinase-activated receptor 2	7040	2150	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	TGF-b1 induces proteinase-activated_receptor_2 -LRB- PAR2 -RRB- expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6 .
23848497	0	TGF-b1	97,103	superficial_zone_protein	46,70	TGF-b1	superficial zone protein	7040	10216	Gene	Gene	explants|nmod|START_ENTITY Induction|nmod|explants Induction|nmod|END_ENTITY	Induction of chondrogenesis and expression of superficial_zone_protein in synovial explants with TGF-b1 and BMP-7 .
22465044	0	TGF-b1	60,66	transforming_growth_factor-b1	29,58	TGF-b1	transforming growth factor-b1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The T29C polymorphism of the transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- gene is associated with genetic susceptibility to acute_coronary_syndrome in Mexican patients .
25449332	0	TGF-b1	72,78	transforming_growth_factor-b1	41,70	TGF-b1	transforming growth factor-b1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The T29C -LRB- rs1800470 -RRB- polymorphism of the transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- gene is associated with restenosis after coronary stenting in Mexican patients .
26753996	0	TGF-b1	48,54	transforming_growth_factor-beta1	14,46	TGF-b1	transforming growth factor-beta1	7040	7040	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of transforming_growth_factor-beta1 -LRB- TGF-b1 -RRB- - induced pro-fibrotic activities by circadian clock gene BMAL1 .
21529804	0	TGF-b1	44,50	transforming_growth_factor-beta_1	9,42	TGF-b1	transforming growth factor-beta 1	7040	7040	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Elevated transforming_growth_factor-beta_1 -LRB- TGF-b1 -RRB- levels in human fracture healing .
24310505	0	TGF-b1	66,72	transforming_growth_factor-beta_1	31,64	TGF-b1	transforming growth factor-beta 1	7040	7040	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Clinical significance of serum transforming_growth_factor-beta_1 -LRB- TGF-b1 -RRB- levels in patients with epithelial_ovarian_cancer .
24771267	0	TGF-b1	41,47	transforming_growth_factor-beta_1	6,39	TGF-b1	transforming growth factor-beta 1	7040	7040	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum transforming_growth_factor-beta_1 -LRB- TGF-b1 -RRB- levels have diagnostic , predictive , and possible prognostic roles in patients with melanoma .
16952379	0	TGF-b1	47,53	transforming_growth_factor_beta	14,45	TGF-b1	transforming growth factor beta	7040	7040	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of transforming_growth_factor_beta -LRB- TGF-b1 -RRB- by human preterm lung inflammatory cells .
22106837	0	TGF-b1	55,61	transforming_growth_factor_beta_1	20,53	TGF-b1	transforming growth factor beta 1	7040	7040	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Prognostic value of transforming_growth_factor_beta_1 -LSB- TGF-b1 -RSB- and matrix_metalloproteinase_9 -LSB- MMP-9 -RSB- in oral_squamous_cell_carcinoma .
25266958	0	TGF-b1	64,70	transforming_growth_factor_beta_1	29,62	TGF-b1	transforming growth factor beta 1	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Placental gene expression of transforming_growth_factor_beta_1 -LRB- TGF-b1 -RRB- in small for gestational age newborns .
26511382	0	TGF-b2	0,6	Grb2	15,19	TGF-b2	Grb2	7042	2885	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TGF-b2 induces Grb2 to recruit PI3-K to TGF-RII that activates JNK/AP -1 - signaling and augments invasiveness of Theileria-transformed macrophages .
24718314	0	TGF-b2	26,32	Osteopontin	0,11	TGF-b2	Osteopontin	7042	6696	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Osteopontin is induced by TGF-b2 and regulates metabolic cell activity in cultured human optic nerve head astrocytes .
26225425	0	TGF-b2	32,38	RhoA	74,78	TGF-b2	RhoA	7042	387	Gene	Gene	START_ENTITY|nmod|Cells Cells|nmod|END_ENTITY	All-Trans_Retinoic_Acid Induces TGF-b2 in Intestinal Epithelial Cells via RhoA - and p38a MAPK-Mediated Activation of the Transcription Factor ATF2 .
23154975	0	TGF-b2	39,45	Smad7	0,5	TGF-b2	Smad7	101009253	101009976	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Smad7 inhibits autocrine expression of TGF-b2 in intestinal epithelial cells in baboon_necrotizing_enterocolitis .
26783748	0	TGF-b2	109,115	VEGF	116,120	TGF-b2	VEGF	81809(Tax:10116)	83785(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	All-Trans_Retinoic_Acid Attenuates Hypoxia-Induced_Injury in NRK52E Cells via Inhibiting NF-x03BA ; B/VEGF and TGF-b2 / VEGF Pathway .
22433307	0	TGF-b3	22,28	TGF-b3	61,67	TGF-b3	TGF-b3	7043	7043	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of exogenous TGF-b3 on the expression of endogenous TGF-b3 in hepatic_stellate_cell-T6 -LRB- HSC-T6 -RRB- -RSB- .
22433307	0	TGF-b3	61,67	TGF-b3	22,28	TGF-b3	TGF-b3	7043	7043	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of exogenous TGF-b3 on the expression of endogenous TGF-b3 in hepatic_stellate_cell-T6 -LRB- HSC-T6 -RRB- -RSB- .
17657621	0	TGF-beta	24,32	5alpha-reductase	50,66	TGF-beta	5alpha-reductase	7040	6715	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	The combined effects of TGF-beta , IGF and PDGF on 5alpha-reductase activity on androgen substrates in human gingival tissue .
17620406	0	TGF-beta	60,68	ADAM12	38,44	TGF-beta	ADAM12	7040	8038	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor .
12134634	0	TGF-beta	31,39	BMPR2	51,56	TGF-beta	BMPR2	7040	659	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	-LSB- Mutations of genes coding for TGF-beta receptors -LRB- BMPR2 and ALK-1 -RRB- in primary pulmonary_arterial_hypertension -RSB- .
11893917	0	TGF-beta	39,47	Basic_fibroblast_growth_factor	0,30	TGF-beta	Basic fibroblast growth factor	59086(Tax:10116)	54250(Tax:10116)	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces TGF-beta release in an isoform and glioma-specific manner .
15136587	0	TGF-beta	0,8	CD163	59,64	TGF-beta	CD163	7040	9332	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	TGF-beta regulation of human macrophage scavenger receptor CD163 is Smad3-dependent .
11390478	0	TGF-beta	11,19	CD25	59,63	TGF-beta	CD25	7040	3559	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|END_ENTITY	A role for TGF-beta in the generation and expansion of CD4 + CD25 + regulatory T cells from human peripheral blood .
12651220	0	TGF-beta	0,8	CD25	34,38	TGF-beta	CD25	7040	3559	Gene	Gene	START_ENTITY|dep|link link|nmod|immunosuppression immunosuppression|compound|END_ENTITY	TGF-beta : the missing link in CD4 + CD25 + regulatory T cell-mediated immunosuppression .
14676299	0	TGF-beta	84,92	CD25	29,33	TGF-beta	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY +|nmod|induction CD25|acl|+ cells|nmod|CD25 Conversion|dep|cells Conversion|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
14676299	0	TGF-beta	84,92	CD25	56,60	TGF-beta	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY +|nmod|induction END_ENTITY|acl|+	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15070759	0	TGF-beta	0,8	CD25	61,65	TGF-beta	CD25	7040	3559	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|+ +|nsubj|expansion expansion|nmod|END_ENTITY	TGF-beta regulates in vivo expansion of Foxp3-expressing CD4 + CD25 + regulatory T cells responsible for protection against diabetes .
15367216	0	TGF-beta	0,8	CD25	55,59	TGF-beta	CD25	7040	3559	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
16612596	0	TGF-beta	94,102	CD25	20,24	TGF-beta	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|END_ENTITY	Tumor-derived CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cell suppression of dendritic cell function involves TGF-beta and IL-10 .
17277105	0	TGF-beta	22,30	CD25	52,56	TGF-beta	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|xcomp|convert convert|dobj|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17277105	0	TGF-beta	22,30	CD25	67,71	TGF-beta	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|xcomp|convert convert|dobj|CD25 CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17353088	0	TGF-beta	128,136	CD25	45,49	TGF-beta	CD25	7040	3559	Gene	Gene	secreting|dobj|START_ENTITY T|advcl|secreting END_ENTITY|acl:relcl|T	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17353088	0	TGF-beta	128,136	CD25	94,98	TGF-beta	CD25	7040	3559	Gene	Gene	secreting|dobj|START_ENTITY T|advcl|secreting T|nsubj|cells cells|nmod|END_ENTITY	Human ovarian_carcinoma cells generate CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells from peripheral CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells through secreting TGF-beta .
17641007	0	TGF-beta	28,36	CD25	94,98	TGF-beta	CD25	7040	3559	Gene	Gene	conversion|amod|START_ENTITY inhibits|dobj|conversion inhibits|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17688698	0	TGF-beta	11,19	CD25	131,135	TGF-beta	CD25	7040	3559	Gene	Gene	activation|amod|START_ENTITY key|nsubj|activation key|nmod|induction induction|nmod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
20684851	0	TGF-beta	15,23	CD25	49,53	TGF-beta	CD25	7040	3559	Gene	Gene	converts|amod|START_ENTITY T|nmod|converts T|nsubj|END_ENTITY	In vitro human TGF-beta treatment converts CD4 -LRB- + -RRB- CD25 -LRB- - -RRB- T cells into induced T regulatory like cells .
24152837	0	TGF-beta	33,41	CD28	54,58	TGF-beta	CD28	7040	940	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	The effects of interleukin-10 or TGF-beta on anti-CD3 / CD28 induced activation of CD8 + CD28 - and CD8 + CD28 + T cells in allergic_asthma .
12651220	0	TGF-beta	0,8	CD4	30,33	TGF-beta	CD4	7040	920	Gene	Gene	START_ENTITY|dep|link link|nmod|immunosuppression immunosuppression|compound|END_ENTITY	TGF-beta : the missing link in CD4 + CD25 + regulatory T cell-mediated immunosuppression .
16517699	0	TGF-beta	0,8	CTLA-4	18,24	TGF-beta	CTLA-4	21803(Tax:10090)	12477(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
20016783	0	TGF-beta	0,8	CTLA-4	75,81	TGF-beta	CTLA-4	7040	1493	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	TGF-beta and IL-10 production by HIV-specific CD8 + T cells is regulated by CTLA-4 signaling on CD4 + T cells .
17641957	0	TGF-beta	28,36	Carboxypeptidase_D	0,18	TGF-beta	Carboxypeptidase D	7040	1362	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	Carboxypeptidase_D : a novel TGF-beta target gene dysregulated in patients with lupus_erythematosus .
12743568	0	TGF-beta	32,40	CysLT1	0,6	TGF-beta	CysLT1	7040	10800	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4 .
11880636	0	TGF-beta	31,39	DEC1	0,4	TGF-beta	DEC1	7040	50514	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities .
10085257	0	TGF-beta	15,23	Dcdc42	0,6	TGF-beta	Dcdc42	43804(Tax:7227)	32981(Tax:7227)	Gene	Gene	acts|nmod|START_ENTITY acts|amod|END_ENTITY	Dcdc42 acts in TGF-beta signaling during Drosophila morphogenesis : distinct roles for the Drac1/JNK and Dcdc42/TGF-beta cascades in cytoskeletal regulation .
12707320	0	TGF-beta	61,69	Decorin	0,7	TGF-beta	Decorin	21803(Tax:10090)	13179(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY reverses|dobj|effect reverses|nsubj|END_ENTITY	Decorin reverses the repressive effect of autocrine-produced TGF-beta on mouse macrophage activation .
17301079	0	TGF-beta	64,72	E-cadherin	42,52	TGF-beta	E-cadherin	7040	999	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic_cancer cell line PANC-1 .
19897661	0	TGF-beta	63,71	EP2	14,17	TGF-beta	EP2	21803(Tax:10090)	19217(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-beta signaling during mammary tumorigenesis .
15504369	0	TGF-beta	55,63	ERK	15,18	TGF-beta	ERK	21803(Tax:10090)	26413(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of ERK , a MAP kinase , in the production of TGF-beta by macrophages treated with liposomes composed of phosphatidylserine .
19657566	0	TGF-beta	0,8	ERK	103,106	TGF-beta	ERK	7040	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|nmod|pathways pathways|compound|END_ENTITY	TGF-beta promotes invasion and metastasis of gastric_cancer cells by increasing fascin1 expression via ERK and JNK signal pathways .
18588859	0	TGF-beta	0,8	ERK5	19,23	TGF-beta	ERK5	7040	5598	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TGF-beta activates ERK5 in human renal epithelial cells .
16530037	0	TGF-beta	0,8	Emilin1	23,30	TGF-beta	Emilin1	21803(Tax:10090)	100952(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	TGF-beta regulation by Emilin1 : new links in the etiology of hypertension .
16530041	0	TGF-beta	14,22	Emilin1	0,7	TGF-beta	Emilin1	21803(Tax:10090)	100952(Tax:10090)	Gene	Gene	maturation|amod|START_ENTITY links|dobj|maturation links|nsubj|END_ENTITY	Emilin1 links TGF-beta maturation to blood pressure homeostasis .
19289088	0	TGF-beta	106,114	Erbin	0,5	TGF-beta	Erbin	7040	55914	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta .
11274757	0	TGF-beta	62,70	FLRG	14,18	TGF-beta	FLRG	7040	10272	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of FLRG , a novel activin A ligand , is regulated by TGF-beta and during hematopoiesis -LSB- corrected -RSB- .
18779564	0	TGF-beta	0,8	FOXP3	90,95	TGF-beta	FOXP3	7040	50943	Gene	Gene	signals|amod|START_ENTITY modulate|nsubj|signals modulate|nmod|END_ENTITY	TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3 .
16837650	0	TGF-beta	68,76	Fibulin-5	0,9	TGF-beta	Fibulin-5	7040	10516	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity .
16517699	0	TGF-beta	0,8	FoxP3	65,70	TGF-beta	FoxP3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|induce induce|dobj|END_ENTITY	TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4 + CD25 + regulatory cells .
17412560	0	TGF-beta	64,72	FoxP3	125,130	TGF-beta	FoxP3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	Converting|nmod|START_ENTITY Converting|advcl|producing producing|dobj|cells cells|nmod|transduction transduction|amod|END_ENTITY	Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction .
14676299	0	TGF-beta	84,92	Foxp3	127,132	TGF-beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Conversion of peripheral CD4 + CD25 - naive T cells to CD4 + CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 .
15100250	0	TGF-beta	14,22	Foxp3	83,88	TGF-beta	Foxp3	7040	50943	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phenotype phenotype|dep|cells cells|nmod|induction induction|amod|END_ENTITY	Cutting edge : TGF-beta induces a regulatory phenotype in CD4 + CD25 - T cells through Foxp3 induction and down-regulation of Smad7 .
15367216	0	TGF-beta	0,8	Foxp3	17,22	TGF-beta	Foxp3	7040	50943	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|amod|END_ENTITY	TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors .
17277105	0	TGF-beta	22,30	Foxp3	72,77	TGF-beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|xcomp|convert convert|dobj|CD25 CD25|dep|cells cells|nmod|cells cells|compound|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
17548603	0	TGF-beta	62,70	Foxp3	34,39	TGF-beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|analysis analysis|nmod|END_ENTITY	A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta .
17641007	0	TGF-beta	28,36	Foxp3	99,104	TGF-beta	Foxp3	7040	50943	Gene	Gene	conversion|amod|START_ENTITY inhibits|dobj|conversion inhibits|nmod|cells cells|compound|END_ENTITY	Cutting edge : OX40 inhibits TGF-beta - and antigen-driven conversion of naive CD4 T cells into CD25 + Foxp3 + T cells .
17688698	0	TGF-beta	11,19	Foxp3	68,73	TGF-beta	Foxp3	7040	50943	Gene	Gene	activation|amod|START_ENTITY key|nsubj|activation key|nmod|induction induction|amod|END_ENTITY	Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4 + CD25 - T cells .
17695668	0	TGF-beta	62,70	Foxp3	34,39	TGF-beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|analysis analysis|nmod|END_ENTITY	A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta .
18029395	0	TGF-beta	19,27	Foxp3	120,125	TGF-beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|reversal reversal|nmod|diabetes diabetes|nmod|mice mice|nmod|cells cells|amod|END_ENTITY	Essential roles of TGF-beta in anti-CD3 antibody therapy : reversal of diabetes in nonobese diabetic mice independent of Foxp3 + CD4 + regulatory T cells .
18395859	0	TGF-beta	29,37	Foxp3	58,63	TGF-beta	Foxp3	7040	50943	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function .
19307989	0	TGF-beta	14,22	Foxp3	50,55	TGF-beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	conversion|amod|START_ENTITY conversion|nmod|END_ENTITY	Tumor-derived TGF-beta mediates conversion of CD4 + Foxp3 + regulatory T cells in a murine model of pancreas_cancer .
19648226	0	TGF-beta	0,8	Foxp3	24,29	TGF-beta	Foxp3	7040	50943	Gene	Gene	adaptive|dep|START_ENTITY END_ENTITY|amod|adaptive	TGF-beta and ` adaptive ' Foxp3 -LRB- + -RRB- regulatory T cells .
19943263	0	TGF-beta	22,30	Foxp3	71,76	TGF-beta	Foxp3	7040	50943	Gene	Gene	members|amod|START_ENTITY effect|nmod|members effect|nmod|induction induction|nmod|Treg Treg|compound|END_ENTITY	Synergistic effect of TGF-beta superfamily members on the induction of Foxp3 + Treg .
20639482	0	TGF-beta	67,75	Foxp3	29,34	TGF-beta	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY cells|acl|induced +|dobj|cells +|nsubj|Identification Identification|nmod|END_ENTITY	Identification of regulatory Foxp3 + invariant NKT cells induced by TGF-beta .
19651619	0	TGF-beta	64,72	GARP	0,4	TGF-beta	GARP	7040	2615	Gene	Gene	expression|nmod|START_ENTITY essential|nmod|expression essential|nsubj|END_ENTITY	GARP -LRB- LRRC32 -RRB- is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3 + regulatory T cells .
19750484	0	TGF-beta	47,55	GARP	17,21	TGF-beta	GARP	7040	2615	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg .
16721050	0	TGF-beta	26,34	GDF3	0,4	TGF-beta	GDF3	7040	9573	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	GDF3 at the crossroads of TGF-beta signaling .
17141511	0	TGF-beta	64,72	GDNF	0,4	TGF-beta	GDNF	7040	2668	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action .
15879107	0	TGF-beta	9,17	G_alpha_i2	53,63	TGF-beta	G alpha i2	21803(Tax:10090)	14678(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Impaired TGF-beta responses in peripheral T cells of G_alpha_i2 - / - mice .
19188499	0	TGF-beta	39,47	Gfi-1	19,24	TGF-beta	Gfi-1	21803(Tax:10090)	14581(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103 + inducible regulatory T cells .
19995547	0	TGF-beta	22,30	Hsp70	62,67	TGF-beta	Hsp70	7040	3308	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|induction induction|nmod|END_ENTITY	Geldanamycin inhibits TGF-beta signaling through induction of Hsp70 .
10193415	0	TGF-beta	201,209	IFN-gamma	70,79	TGF-beta	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
11352993	0	TGF-beta	0,8	IFN-gamma	117,126	TGF-beta	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|parataxis|opposing opposing|dobj|effects effects|nmod|END_ENTITY	TGF-beta increases cholesterol efflux and ABC-1 expression in macrophage-derived foam cells : opposing the effects of IFN-gamma .
11557514	0	TGF-beta	0,8	IFN-gamma	33,42	TGF-beta	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	TGF-beta and IL-10 regulation of IFN-gamma produced in Th2-type schistosome granulomas requires IL-12 .
12788525	0	TGF-beta	49,57	IFN-gamma	0,9	TGF-beta	IFN-gamma	7040	3458	Gene	Gene	effect|nmod|START_ENTITY antagonize|dobj|effect fails|xcomp|antagonize fails|nsubj|END_ENTITY	IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts .
16644489	0	TGF-beta	62,70	IFN-gamma	14,23	TGF-beta	IFN-gamma	7040	3458	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|compound|END_ENTITY	Human NK cell IFN-gamma production is regulated by endogenous TGF-beta .
17125875	0	TGF-beta	34,42	IFN-gamma	0,9	TGF-beta	IFN-gamma	7040	3458	Gene	Gene	signaling|amod|START_ENTITY abrogates|dobj|signaling abrogates|nsubj|END_ENTITY	IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads .
18340648	0	TGF-beta	58,66	IFN-gamma	100,109	TGF-beta	IFN-gamma	59086(Tax:10116)	25712(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|production production|amod|END_ENTITY	Reduced responsiveness of HLA-B27 transgenic rat cells to TGF-beta and IL-10-mediated regulation of IFN-gamma production .
18466611	0	TGF-beta	112,120	IFN-gamma	73,82	TGF-beta	IFN-gamma	59086(Tax:10116)	25712(Tax:10116)	Gene	Gene	reversed|nmod|START_ENTITY reversed|nsubjpass|Decrease Decrease|nmod|PECAM-1-gene-expression PECAM-1-gene-expression|acl|induced induced|nmod|END_ENTITY	Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes .
18600325	0	TGF-beta	34,42	IFN-gamma	68,77	TGF-beta	IFN-gamma	7040	3458	Gene	Gene	IL-17|dep|START_ENTITY cytokines|appos|IL-17 cytokines|appos|END_ENTITY	Profile of Th17 cytokines -LRB- IL-17 , TGF-beta , IL-6 -RRB- and Th1 cytokine -LRB- IFN-gamma -RRB- in patients with immune_thrombocytopenic_purpura .
18768831	0	TGF-beta	0,8	IFN-gamma	49,58	TGF-beta	IFN-gamma	7040	3458	Gene	Gene	utilizes|amod|START_ENTITY SMAD3|nsubj|utilizes SMAD3|xcomp|inhibit inhibit|dobj|production production|amod|END_ENTITY	TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent_cellular_cytotoxicity in human NK cells .
19956908	0	TGF-beta	0,8	IFN-gamma	50,59	TGF-beta	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	superfamily|amod|START_ENTITY enhances|nsubj|superfamily enhances|dobj|production production|amod|END_ENTITY	TGF-beta superfamily enhances the antigen-induced IFN-gamma production by effector/memory CD8 + T cells .
9036950	0	TGF-beta	0,8	IFN-gamma	20,29	TGF-beta	IFN-gamma	7040	3458	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|induction induction|amod|END_ENTITY	TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class_II_transactivator messenger RNA expression .
9099937	0	TGF-beta	100,108	IFN-gamma	46,55	TGF-beta	IFN-gamma	59086(Tax:10116)	25712(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Cellular mRNA expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- in rats nasally tolerized against experimental autoimmune_myasthenia_gravis -LRB- EAMG -RRB- .
9120265	0	TGF-beta	0,8	IFN-gamma	24,33	TGF-beta	IFN-gamma	7040	3458	Gene	Gene	stimulates|amod|START_ENTITY stimulates|nmod|END_ENTITY	TGF-beta stimulates but IFN-gamma inhibits growth-related activation of locomotion of human B cells .
11441082	0	TGF-beta	14,22	IL-10	73,78	TGF-beta	IL-10	7040	3586	Gene	Gene	response|amod|START_ENTITY Regulation|nmod|response modulated|nsubjpass|Regulation modulated|nmod|END_ENTITY	Regulation of TGF-beta response during T cell activation is modulated by IL-10 .
15848524	0	TGF-beta	36,44	IL-10	63,68	TGF-beta	IL-10	7040	3586	Gene	Gene	TNF-alpha|compound|START_ENTITY TNF-alpha|dep|MCP-1 MCP-1|dep|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
16809410	0	TGF-beta	123,131	IL-10	8,13	TGF-beta	IL-10	21803(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY inhibiting|dobj|production pulmonary_fibrosis|advcl|inhibiting pulmonary_fibrosis|nmod|attenuates attenuates|compound|END_ENTITY	In vivo IL-10 gene delivery attenuates bleomycin induced pulmonary_fibrosis by inhibiting the production and activation of TGF-beta in the lung .
17237391	0	TGF-beta	116,124	IL-10	97,102	TGF-beta	IL-10	21803(Tax:10090)	16153(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Naturally occurring lung CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta .
18972297	0	TGF-beta	7,15	IL-10	0,5	TGF-beta	IL-10	7040	3586	Gene	Gene	IL-12|appos|START_ENTITY IL-12|compound|END_ENTITY	IL-10 , TGF-beta , IL-2 , IL-12 , and IFN-gamma cytokine gene polymorphisms in asthma .
7594497	0	TGF-beta	0,8	IL-10	48,53	TGF-beta	IL-10	21803(Tax:10090)	16153(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|ability ability|acl|produce produce|dobj|END_ENTITY	TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice .
20640990	0	TGF-beta	44,52	IL-11	10,15	TGF-beta	IL-11	59086(Tax:10116)	171040(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of IL-11 on glomerular expression of TGF-beta and extracellular matrix in nephrotoxic_nephritis in Wistar Kyoto rats .
17324400	0	TGF-beta	14,22	IL-15	36,41	TGF-beta	IL-15	7040	3600	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Inhibition of TGF-beta signaling by IL-15 : a new role for IL-15 in the loss of immune homeostasis in celiac_disease .
17324400	0	TGF-beta	14,22	IL-15	58,63	TGF-beta	IL-15	7040	3600	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of TGF-beta signaling by IL-15 : a new role for IL-15 in the loss of immune homeostasis in celiac_disease .
17277105	0	TGF-beta	22,30	IL-2	0,4	TGF-beta	IL-2	21803(Tax:10090)	16183(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	IL-2 is essential for TGF-beta to convert naive CD4 + CD25 - cells to CD25 + Foxp3 + regulatory T cells and for expansion of these cells .
18209044	0	TGF-beta	0,8	IL-2	18,22	TGF-beta	IL-2	7040	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	TGF-beta inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction .
20042469	0	TGF-beta	65,73	IL-21	97,102	TGF-beta	IL-21	7040	59067	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	c-Maf activates the promoter and enhancer of the IL-21 gene , and TGF-beta inhibits c-Maf-induced IL-21 production in CD4 + T cells .
7955537	0	TGF-beta	88,96	IL-4	46,50	TGF-beta	IL-4	59086(Tax:10116)	287287(Tax:10116)	Gene	Gene	factor-beta|appos|START_ENTITY factor-beta|compound|END_ENTITY	Cellular mRNA expression of interferon-gamma , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental_allergic_neuritis .
9637480	0	TGF-beta	141,149	IL-4	93,97	TGF-beta	IL-4	21803(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY have|advcl|regulates have|nsubj|END_ENTITY	Factors involved in the differentiation of TGF-beta-producing cells from naive CD4 + T cells : IL-4 and IFN-gamma have opposing effects , while TGF-beta positively regulates its own production .
9794401	0	TGF-beta	25,33	IL-4	0,4	TGF-beta	IL-4	21803(Tax:10090)	16189(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	IL-4 in combination with TGF-beta favors an alternative pathway of Th1 development independent of IL-12 .
12406387	0	TGF-beta	31,39	IL-6	72,76	TGF-beta	IL-6	7040	3569	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Up-regulation of production of TGF-beta and IL-4 and down-regulation of IL-6 by apoptotic human bronchial epithelial cells .
15485627	0	TGF-beta	0,8	IL-6	71,75	TGF-beta	IL-6	21803(Tax:10090)	16193(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|inhibition inhibition|nmod|trans-signaling trans-signaling|compound|END_ENTITY	TGF-beta suppresses tumor progression in colon_cancer by inhibition of IL-6 trans-signaling .
15848524	0	TGF-beta	36,44	IL-6	57,61	TGF-beta	IL-6	7040	3569	Gene	Gene	TNF-alpha|compound|START_ENTITY TNF-alpha|dep|MCP-1 MCP-1|compound|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
18600325	0	TGF-beta	34,42	IL-6	44,48	TGF-beta	IL-6	7040	3569	Gene	Gene	IL-17|dep|START_ENTITY IL-17|dep|END_ENTITY	Profile of Th17 cytokines -LRB- IL-17 , TGF-beta , IL-6 -RRB- and Th1 cytokine -LRB- IFN-gamma -RRB- in patients with immune_thrombocytopenic_purpura .
19501566	0	TGF-beta	0,8	IL-6	74,78	TGF-beta	IL-6	7040	3569	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23 .
20713723	0	TGF-beta	0,8	IL-6	9,13	TGF-beta	IL-6	21803(Tax:10090)	3569	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung_cancer .
7751003	0	TGF-beta	0,8	IL-6	49,53	TGF-beta	IL-6	7040	3569	Gene	Gene	act|nsubj|START_ENTITY act|xcomp|enhance enhance|dobj|levels levels|amod|END_ENTITY	TGF-beta and IL-1_beta act in synergy to enhance IL-6 and IL-8 mRNA levels and IL-6 production by human retinal_pigment_epithelial cells .
7858060	0	TGF-beta	14,22	IL-6	153,157	TGF-beta	IL-6	7040	3569	Gene	Gene	isoforms|amod|START_ENTITY Expression|nmod|isoforms Expression|dep|evidence evidence|nmod|TGF-beta TGF-beta|nmod|regulator regulator|nmod|stimulation stimulation|nmod|END_ENTITY	Expression of TGF-beta isoforms by Thy-1 + and Thy-1 - pulmonary fibroblast subsets : evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6 .
7858060	0	TGF-beta	96,104	IL-6	153,157	TGF-beta	IL-6	7040	3569	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|stimulation stimulation|nmod|END_ENTITY	Expression of TGF-beta isoforms by Thy-1 + and Thy-1 - pulmonary fibroblast subsets : evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6 .
11937570	0	TGF-beta	109,117	IL-9	0,4	TGF-beta	IL-9	7040	3578	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta .
20498357	0	TGF-beta	0,8	IL-9	17,21	TGF-beta	IL-9	7040	3578	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	TGF-beta induces IL-9 production from human Th17 cells .
19137015	0	TGF-beta	0,8	Id2	23,26	TGF-beta	Id2	59086(Tax:10116)	25587(Tax:10116)	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	TGF-beta repression of Id2 induces apoptosis in gut epithelial cells .
17194892	0	TGF-beta	16,24	KLF2	0,4	TGF-beta	KLF2	7040	10365	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1 .
19076057	0	TGF-beta	0,8	KLF6	58,62	TGF-beta	KLF6	7040	1316	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3-Sp1-KLF6 interaction .
7590899	0	TGF-beta	10,18	LIM	80,83	TGF-beta	LIM	7040	10611	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of TGF-beta on differentiated organoids of the colon_carcinoma cell line LIM 1863 .
15848524	0	TGF-beta	36,44	MCP-1	70,75	TGF-beta	MCP-1	7040	6347	Gene	Gene	TNF-alpha|compound|START_ENTITY TNF-alpha|dep|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
19383287	0	TGF-beta	70,78	Meox2	19,24	TGF-beta	Meox2	7040	4223	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of Meox2 during the epithelial cytostatic response to TGF-beta .
15496141	0	TGF-beta	99,107	NEDD4-2	0,7	TGF-beta	NEDD4-2	7040	23327	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	NEDD4-2 -LRB- neural precursor cell expressed , developmentally down-regulated 4-2 -RRB- negatively regulates TGF-beta -LRB- transforming_growth_factor-beta -RRB- signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta_type_I_receptor .
16288847	0	TGF-beta	56,64	NF-kappaB	43,52	TGF-beta	NF-kappaB	7040	4790	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon_cancer cells .
20150362	0	TGF-beta	0,8	NKG2D	47,52	TGF-beta	NKG2D	7040	22914	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	TGF-beta downregulates the activating receptor NKG2D on NK cells and CD8 + T cells in glioma patients .
22728268	0	TGF-beta	20,28	Nox4	0,4	TGF-beta	Nox4	7040	50507	Gene	Gene	involvement|nmod|START_ENTITY involvement|amod|END_ENTITY	Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells .
10209301	0	TGF-beta	15,23	PAI-1	60,65	TGF-beta	PAI-1	59086(Tax:10116)	29366(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|acl|signaling signaling|nmod|upregulation upregulation|compound|END_ENTITY	Association of TGF-beta signaling in angiotensin_II-induced PAI-1 mRNA upregulation in mesangial cells : role of PKC .
16105028	0	TGF-beta	59,67	PAI-1	34,39	TGF-beta	PAI-1	59086(Tax:10116)	24617(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	MAPK/AP -1 - dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells .
19852794	0	TGF-beta	0,8	PAR-2	37,42	TGF-beta	PAR-2	7040	2150	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells .
19081068	0	TGF-beta	0,8	PAX3	17,21	TGF-beta	PAX3	7040	5077	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	TGF-beta targets PAX3 to control melanocyte differentiation .
17977532	0	TGF-beta	0,8	POEM	20,24	TGF-beta	POEM	21803(Tax:10090)	114249(Tax:10090)	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	TGF-beta suppresses POEM expression through ERK1/2 and JNK in osteoblasts .
18239055	0	TGF-beta	0,8	PTEN	18,22	TGF-beta	PTEN	7040	5728	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	TGF-beta mediates PTEN suppression and cell motility through calcium-dependent PKC-alpha activation in pancreatic_cancer cells .
19940030	0	TGF-beta	0,8	PTEN	23,27	TGF-beta	PTEN	7040	5728	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	TGF-beta downregulates PTEN via activation of NF-kappaB in pancreatic_cancer cells .
17720884	0	TGF-beta	23,31	PTPRK	45,50	TGF-beta	PTPRK	7040	5796	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Down-regulation of the TGF-beta target gene , PTPRK , by the Epstein-Barr_virus encoded EBNA1 contributes to the growth and survival of Hodgkin_lymphoma cells .
19725029	0	TGF-beta	21,29	Prohibitin	0,10	TGF-beta	Prohibitin	7040	5245	Gene	Gene	apoptosis|amod|START_ENTITY regulates|dobj|apoptosis regulates|nsubj|END_ENTITY	Prohibitin regulates TGF-beta induced apoptosis as a downstream effector of Smad-dependent and - independent signaling .
15848524	0	TGF-beta	36,44	RANTES	77,83	TGF-beta	RANTES	7040	6352	Gene	Gene	TNF-alpha|compound|START_ENTITY TNF-alpha|dep|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
7556459	0	TGF-beta	0,8	RAR-beta	59,67	TGF-beta	RAR-beta	21803(Tax:10090)	218772(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	TGF-beta modulates the expression of retinoic_acid-induced RAR-beta in primary cultures of embryonic_palate cells .
14680513	0	TGF-beta	0,8	SAP30L	35,41	TGF-beta	SAP30L	7040	79685	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	TGF-beta induces the expression of SAP30L , a novel nuclear protein .
20212457	0	TGF-beta	19,27	SERPINB3	0,8	TGF-beta	SERPINB3	7040	6317	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	SERPINB3 modulates TGF-beta expression in chronic_liver_disease .
10064594	0	TGF-beta	106,114	SMAD3	23,28	TGF-beta	SMAD3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	responsiveness|nmod|START_ENTITY responsiveness|nsubj|disruption disruption|nmod|results results|nummod|END_ENTITY	Targeted disruption of SMAD3 results in impaired_mucosal_immunity and diminished T cell responsiveness to TGF-beta .
18768831	0	TGF-beta	0,8	SMAD3	18,23	TGF-beta	SMAD3	7040	4088	Gene	Gene	utilizes|amod|START_ENTITY END_ENTITY|nsubj|utilizes	TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent_cellular_cytotoxicity in human NK cells .
19032343	0	TGF-beta	69,77	SMAD7	91,96	TGF-beta	SMAD7	7040	4092	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ski co-repressor complexes maintain the basal repressed state of the TGF-beta target gene , SMAD7 , via HDAC3 and PRMT5 .
19578009	0	TGF-beta	33,41	SMOC-1	56,62	TGF-beta	SMOC-1	59086(Tax:10116)	314280(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Nitric_oxide inhibits glomerular TGF-beta signaling via SMOC-1 .
14555988	0	TGF-beta	27,35	Smad2	54,59	TGF-beta	Smad2	7040	4087	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Differential regulation of TGF-beta signaling through Smad2 , Smad3 and Smad4 .
17340614	0	TGF-beta	80,88	Smad2	61,66	TGF-beta	Smad2	21803(Tax:10090)	17126(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	A tale of two proteins : differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling .
10549282	0	TGF-beta	56,64	Smad3	40,45	TGF-beta	Smad3	7040	4088	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|Interaction Interaction|nmod|Ski_oncoprotein Ski_oncoprotein|nmod|END_ENTITY	Interaction of the Ski_oncoprotein with Smad3 regulates TGF-beta signaling .
11418665	0	TGF-beta	33,41	Smad3	4,9	TGF-beta	Smad3	7040	4088	Gene	Gene	inhibition|amod|START_ENTITY involved|nmod|inhibition involved|nsubjpass|protein protein|amod|END_ENTITY	The Smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression .
11711431	0	TGF-beta	0,8	Smad3	108,113	TGF-beta	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3 .
12051713	0	TGF-beta	100,108	Smad3	14,19	TGF-beta	Smad3	7040	4088	Gene	Gene	signaling|compound|START_ENTITY loop|nmod|signaling Regulation|dep|loop Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Smad3 expression in bleomycin-induced pulmonary_fibrosis : a negative feedback loop of TGF-beta signaling .
12504095	0	TGF-beta	33,41	Smad3	18,23	TGF-beta	Smad3	7040	4088	Gene	Gene	response|amod|START_ENTITY restores|dobj|response restores|nsubj|Reconstitution Reconstitution|nmod|END_ENTITY	Reconstitution of Smad3 restores TGF-beta response of tissue inhibitor of metalloprotease-1 upregulation in human choriocarcinoma cells .
12814934	0	TGF-beta	60,68	Smad3	0,5	TGF-beta	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY mechanisms|amod|dependent player|nmod|mechanisms END_ENTITY|dep|player	Smad3 : a key player in pathogenetic mechanisms dependent on TGF-beta .
15048128	0	TGF-beta	18,26	Smad3	72,77	TGF-beta	Smad3	7040	4088	Gene	Gene	signalling|amod|START_ENTITY modulates|dobj|signalling modulates|nmod|interaction interaction|nmod|END_ENTITY	PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3 .
15104092	0	TGF-beta	65,73	Smad3	28,33	TGF-beta	Smad3	7040	4088	Gene	Gene	apoptosis|amod|START_ENTITY regulate|nmod|apoptosis interacts|xcomp|regulate interacts|nmod|END_ENTITY	Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis .
15990875	0	TGF-beta	32,40	Smad3	97,102	TGF-beta	Smad3	7040	4088	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3 .
16828225	0	TGF-beta	27,35	Smad3	107,112	TGF-beta	Smad3	7040	4088	Gene	Gene	pathway|amod|START_ENTITY alterations|nmod|pathway alterations|dep|mutation mutation|nmod|END_ENTITY	Genetic alterations of the TGF-beta signaling pathway in colorectal_cancer cell lines : a novel mutation in Smad3 associated with the inactivation of TGF-beta-induced transcriptional activation .
16877415	0	TGF-beta	28,36	Smad3	103,108	TGF-beta	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|nsubj|expression induces|nmod|absence absence|nmod|END_ENTITY	Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3 .
17934056	0	TGF-beta	24,32	Smad3	57,62	TGF-beta	Smad3	7040	4088	Gene	Gene	action|nmod|START_ENTITY Mechanisms|nmod|action Mechanisms|dep|evidence evidence|nmod|END_ENTITY	Mechanisms of action of TGF-beta in cancer : evidence for Smad3 as a repressor of the hTERT gene .
18794808	0	TGF-beta	98,106	Smad3	35,40	TGF-beta	Smad3	7040	4088	Gene	Gene	signaling|compound|START_ENTITY inhibitor|nmod|signaling casein_kinase_1_gamma_2|appos|inhibitor regulated|nmod|casein_kinase_1_gamma_2 regulated|nsubjpass|ubiquitination ubiquitination|nmod|END_ENTITY	Ligand-dependent ubiquitination of Smad3 is regulated by casein_kinase_1_gamma_2 , an inhibitor of TGF-beta signaling .
19079362	0	TGF-beta	51,59	Smad3	0,5	TGF-beta	Smad3	7040	4088	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Smad3 mediates immediate early induction of Id1 by TGF-beta .
9665135	0	TGF-beta	32,40	Smad3	66,71	TGF-beta	Smad3	7040	4088	Gene	Gene	signalling|amod|START_ENTITY represses|dobj|signalling represses|nmod|END_ENTITY	The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3 .
9796704	0	TGF-beta	87,95	Smad3	26,31	TGF-beta	Smad3	7040	4088	Gene	Gene	response|nmod|START_ENTITY expression|nmod|response Induction|nmod|expression Induction|nmod|apoptosis apoptosis|nmod|END_ENTITY	Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells .
9796704	0	TGF-beta	87,95	Smad3	55,60	TGF-beta	Smad3	7040	4088	Gene	Gene	response|nmod|START_ENTITY expression|nmod|response expression|amod|END_ENTITY	Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells .
11230153	0	TGF-beta	55,63	Smad4	113,118	TGF-beta	Smad4	7040	4089	Gene	Gene	family|amod|START_ENTITY family|acl|signaling signaling|nmod|END_ENTITY	The hepatitis_B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4 : potential mechanism of hepatitis_B virus-induced liver_fibrosis .
11352818	0	TGF-beta	68,76	Smad4	55,60	TGF-beta	Smad4	59086(Tax:10116)	50554(Tax:10116)	Gene	Gene	blocks|dobj|START_ENTITY blocks|nsubj|transfer transfer|nmod|END_ENTITY	Adenovirus-mediated gene transfer of dominant-negative Smad4 blocks TGF-beta signaling in pancreatic acinar cells .
11401854	0	TGF-beta	66,74	Smad4	0,5	TGF-beta	Smad4	59086(Tax:10116)	50554(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells .
12548549	0	TGF-beta	61,69	Smad4	14,19	TGF-beta	Smad4	7040	4089	Gene	Gene	inhibition|amod|START_ENTITY restores|dobj|inhibition restores|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Smad4 in the FaDu cell line partially restores TGF-beta growth inhibition but is not sufficient to regulate fibronectin expression or suppress tumorigenicity .
15110786	0	TGF-beta	26,34	Smad4	124,129	TGF-beta	Smad4	7040	4089	Gene	Gene	analysis|nmod|START_ENTITY analysis|acl|signaling signaling|nmod|cells cells|acl|using using|nmod|expression expression|amod|END_ENTITY	Proteomic analysis of the TGF-beta signaling pathway in pancreatic_carcinoma cells using stable RNA interference to silence Smad4 expression .
15881652	0	TGF-beta	16,24	Smad4	55,60	TGF-beta	Smad4	21803(Tax:10090)	17128(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|associating associating|nmod|END_ENTITY	Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation .
17023741	0	TGF-beta	32,40	Smad4	23,28	TGF-beta	Smad4	7040	4089	Gene	Gene	molecule|amod|START_ENTITY END_ENTITY|appos|molecule	Aberrant expression of Smad4 , a TGF-beta signaling molecule , in oral_squamous_cell_carcinoma .
17132729	0	TGF-beta	127,135	Smad4	0,5	TGF-beta	Smad4	7040	4089	Gene	Gene	signaling|compound|START_ENTITY absence|nmod|signaling cooperates|nmod|absence cooperates|nsubj|END_ENTITY	Smad4 cooperates with lymphoid_enhancer-binding_factor_1 / T_cell-specific_factor_to_increase_c-myc expression in the absence of TGF-beta signaling .
17301079	0	TGF-beta	64,72	Smad4	0,5	TGF-beta	Smad4	7040	4089	Gene	Gene	induced|nmod|START_ENTITY E-cadherin|acl|induced down-regulation|nmod|E-cadherin essential|nmod|down-regulation essential|nsubj|END_ENTITY	Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic_cancer cell line PANC-1 .
19144825	0	TGF-beta	42,50	Smad4	27,32	TGF-beta	Smad4	7040	4089	Gene	Gene	disrupts|dobj|START_ENTITY disrupts|nsubj|Association Association|nmod|v-ErbA v-ErbA|nmod|END_ENTITY	Association of v-ErbA with Smad4 disrupts TGF-beta signaling .
20577838	0	TGF-beta	43,51	Smad4	10,15	TGF-beta	Smad4	7040	4089	Gene	Gene	pathway|amod|START_ENTITY microRNA-146a|nmod|pathway links|xcomp|microRNA-146a links|nsubj|END_ENTITY	Targeting Smad4 links microRNA-146a to the TGF-beta pathway during retinoid_acid induction in acute_promyelocytic_leukemia cell line .
10843994	0	TGF-beta	10,18	Smad7	118,123	TGF-beta	Smad7	21803(Tax:10090)	17131(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY requires|nsubj|induction requires|nmod|promoter promoter|compound|END_ENTITY	Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1 , Sp1 , and Smad proteins on the mouse Smad7 promoter .
10843994	0	TGF-beta	10,18	Smad7	36,41	TGF-beta	Smad7	21803(Tax:10090)	17131(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|gene gene|amod|END_ENTITY	Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1 , Sp1 , and Smad proteins on the mouse Smad7 promoter .
10887185	0	TGF-beta	77,85	Smad7	109,114	TGF-beta	Smad7	59086(Tax:10116)	81516(Tax:10116)	Gene	Gene	beta|appos|START_ENTITY transforming|dobj|beta Participation|acl|transforming Participation|dep|activation activation|nmod|END_ENTITY	Participation of Smad2 , Smad3 , and Smad4 in transforming growth factor beta -LRB- TGF-beta -RRB- - induced activation of Smad7 .
14657019	0	TGF-beta	18,26	Smad7	73,78	TGF-beta	Smad7	7040	4092	Gene	Gene	superfamily|amod|START_ENTITY superfamily|acl|signalling signalling|nmod|degradation degradation|nmod|END_ENTITY	Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 .
15885643	0	TGF-beta	78,86	Smad7	51,56	TGF-beta	Smad7	7040	4092	Gene	Gene	expression|amod|START_ENTITY elevation|nmod|expression Increase|nmod|elevation Increase|nmod|T-cells T-cells|nmod|END_ENTITY	Increase of activated T-cells and up-regulation of Smad7 without elevation of TGF-beta expression in tonsils from patients with pustulosis_palmaris et plantaris .
16443684	0	TGF-beta	22,30	Smad7	44,49	TGF-beta	Smad7	7040	4092	Gene	Gene	disruption|nmod|START_ENTITY leads|nmod|disruption leads|csubj|signaling signaling|nmod|END_ENTITY	In vivo disruption of TGF-beta signaling by Smad7 leads to premalignant_ductal_lesions in the pancreas .
16601693	0	TGF-beta	30,38	Smad7	78,83	TGF-beta	Smad7	7040	4092	Gene	Gene	signaling|compound|START_ENTITY signaling|acl:relcl|promotes promotes|dobj|degradation degradation|nmod|END_ENTITY	Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia .
17194892	0	TGF-beta	16,24	Smad7	71,76	TGF-beta	Smad7	7040	4092	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|induction induction|nmod|END_ENTITY	KLF2 suppresses TGF-beta signaling in endothelium through induction of Smad7 and inhibition of AP-1 .
18189266	0	TGF-beta	64,72	Smad7	124,129	TGF-beta	Smad7	7040	4092	Gene	Gene	pathway|amod|START_ENTITY enhances|dobj|pathway enhances|nmod|repression repression|nmod|END_ENTITY	Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7 .
18992195	0	TGF-beta	76,84	Smad7	1,6	TGF-beta	Smad7	7040	4092	Gene	Gene	induced|nmod|START_ENTITY transition|acl|induced blocks|dobj|transition blocks|nsubj|END_ENTITY	-LSB- Smad7 instead of Smad6 blocks epithelial-mesenchymal transition induced by TGF-beta in human renal proximal tubule epithelial cells -RSB- .
19352540	0	TGF-beta	14,22	Smad7	36,41	TGF-beta	Smad7	7040	4092	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of TGF-beta signaling by Smad7 .
19878580	0	TGF-beta	72,80	Smad7	61,66	TGF-beta	Smad7	7040	4092	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|nmod|proteins	Liver_fibrosis secondary to bile_duct_injury : correlation of Smad7 with TGF-beta and extracellular matrix proteins .
20405019	0	TGF-beta	22,30	Smad7	44,49	TGF-beta	Smad7	21803(Tax:10090)	17131(Tax:10090)	Gene	Gene	disruption|nmod|START_ENTITY alleviates|nmod|disruption alleviates|csubj|signaling signaling|nmod|END_ENTITY	In vivo disruption of TGF-beta signaling by Smad7 in airway epithelium alleviates allergic_asthma but aggravates lung_carcinogenesis in mouse .
9335507	0	TGF-beta	59,67	Smad7	18,23	TGF-beta	Smad7	7040	4092	Gene	Gene	signalling|amod|START_ENTITY Identification|nmod|signalling Identification|nmod|END_ENTITY	Identification of Smad7 , a TGFbeta-inducible antagonist of TGF-beta signalling .
20515759	0	TGF-beta	46,54	Smad_anchor_for_receptor_activation	0,35	TGF-beta	Smad anchor for receptor activation	7040	9372	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Smad_anchor_for_receptor_activation -LRB- SARA -RRB- in TGF-beta signaling .
16109768	0	TGF-beta	70,78	SnoN	12,16	TGF-beta	SnoN	7040	6498	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins .
18537639	0	TGF-beta	8,16	SnoN	0,4	TGF-beta	SnoN	7040	6498	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	SnoN in TGF-beta signaling and cancer biology .
7603044	0	TGF-beta	25,33	TGF-beta	46,54	TGF-beta	TGF-beta	59086(Tax:10116)	59086(Tax:10116)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Matrix-associated latent TGF-beta with latent TGF-beta binding protein in the progressive process in adriamycin-induced nephropathy .
7603044	0	TGF-beta	46,54	TGF-beta	25,33	TGF-beta	TGF-beta	59086(Tax:10116)	59086(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Matrix-associated latent TGF-beta with latent TGF-beta binding protein in the progressive process in adriamycin-induced nephropathy .
8133057	0	TGF-beta	37,45	TGF-beta_3	80,90	TGF-beta	TGF-beta 3	7040	7043	Gene	Gene	isoforms|amod|START_ENTITY response|nmod|isoforms chemotaxis|nmod|response chemotaxis|appos|END_ENTITY	Neutrophil chemotaxis in response to TGF-beta isoforms -LRB- TGF-beta_1 , TGF-beta_2 , TGF-beta_3 -RRB- is mediated by fibronectin .
8562514	0	TGF-beta	61,69	TGF-beta_3	38,48	TGF-beta	TGF-beta 3	7040	7043	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Human thymic epithelial cells produce TGF-beta_3 and express TGF-beta receptors .
16258068	0	TGF-beta	51,59	TGF-beta_type_II_receptor	90,115	TGF-beta	TGF-beta type II receptor	7040	7048	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|inactivating inactivating|dobj|END_ENTITY	The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta_type_II_receptor .
10193415	0	TGF-beta	201,209	TNF-alpha	115,124	TGF-beta	TNF-alpha	21803(Tax:10090)	21926(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
11122238	0	TGF-beta	84,92	TNF-alpha	39,48	TGF-beta	TNF-alpha	21803(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor-beta|appos|START_ENTITY transforming|dobj|factor-beta factor-alpha|dep|transforming factor-alpha|appos|END_ENTITY	Roles of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , transforming growth factor-beta -LRB- TGF-beta -RRB- , and IL-10 in the modulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by macrophages during mycobacterial_infection .
18252868	0	TGF-beta	29,37	TNF-alpha	68,77	TGF-beta	TNF-alpha	7040	7124	Gene	Gene	receptor|amod|START_ENTITY up-regulation|nmod|receptor associated|nsubjpass|up-regulation associated|nmod|expression expression|amod|END_ENTITY	LPS-induced up-regulation of TGF-beta receptor 1 is associated with TNF-alpha expression in human monocyte-derived macrophages .
7572286	0	TGF-beta	75,83	TNF-alpha	37,46	TGF-beta	TNF-alpha	59086(Tax:10116)	24835(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta , IL-6 and IL-10 .
7900924	0	TGF-beta	35,43	TNF-alpha	0,9	TGF-beta	TNF-alpha	59086(Tax:10116)	24835(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY regulate|dobj|synthesis regulate|nsubj|END_ENTITY	TNF-alpha , TSH , and aging regulate TGF-beta synthesis and secretion in FRTL-5 rat thyroid cells .
18758450	0	TGF-beta	11,19	TRAF6	37,42	TGF-beta	TRAF6	7040	7189	Gene	Gene	receptor|compound|START_ENTITY engages|nsubj|receptor engages|dobj|END_ENTITY	The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner .
18922473	0	TGF-beta	61,69	TRAF6	0,5	TGF-beta	TRAF6	7040	7189	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta .
10906776	0	TGF-beta	14,22	TSC-22	44,50	TGF-beta	TSC-22	21803(Tax:10090)	21807(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY stimulated|nsubj|Expression stimulated|dobj|END_ENTITY	Expression of TGF-beta stimulated clone-22 -LRB- TSC-22 -RRB- in mouse development and TGF-beta signalling .
12393030	0	TGF-beta	100,108	Th1	112,115	TGF-beta	Th1	7040	51497	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Th1 down-regulation at the single-lymphocyte level in HCV-related liver cirrhosis and the effect of TGF-beta on Th1 response : possible implications for the development of hepatoma .
14992427	0	TGF-beta	33,41	Transforming_growth_factor-beta	0,31	TGF-beta	Transforming growth factor-beta	7040	7040	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- protein levels are not elevated in the blood or bile of patients with primary_sclerosing_cholangitis : a pilot study .
15041079	0	TGF-beta	169,177	Transforming_growth_factor-beta	0,31	TGF-beta	Transforming growth factor-beta	7040	7040	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- - resistant B cells from chronic_lymphocytic_leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor .
8697616	0	TGF-beta	33,41	Transforming_growth_factor-beta	0,31	TGF-beta	Transforming growth factor-beta	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- expression and interaction with proteinase_3 -LRB- PR3 -RRB- in anti-neutrophil cytoplasmic antibody -LRB- ANCA -RRB- - associated vasculitis .
15881652	0	TGF-beta	16,24	Tsc-22	0,6	TGF-beta	Tsc-22	21803(Tax:10090)	21807(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation .
1321201	0	TGF-beta	45,53	bFGF	27,31	TGF-beta	bFGF	7040	2247	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|receptors receptors|compound|END_ENTITY	Differential modulation of bFGF receptors by TGF-beta in adult skin , scleroderma skin , and newborn foreskin fibroblasts .
20213272	0	TGF-beta	0,8	biglycan	20,28	TGF-beta	biglycan	7040	633	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	TGF-beta stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2 .
10462047	0	TGF-beta	0,8	c-Jun_N-terminal_kinase	60,83	TGF-beta	c-Jun N-terminal kinase	21803(Tax:10090)	26419(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	TGF-beta inhibits lipopolysaccharide-stimulated activity of c-Jun_N-terminal_kinase in mouse macrophages .
16045809	0	TGF-beta	81,89	cathepsin_K	18,29	TGF-beta	cathepsin K	21803(Tax:10090)	13038(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of cathepsin_K during silica-induced lung_fibrosis and control by TGF-beta .
12811822	0	TGF-beta	85,93	cyclin_D1	60,69	TGF-beta	cyclin D1	59086(Tax:10116)	58919(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Eicosapentaenoic_acid inhibits PDGF-induced mitogenesis and cyclin_D1 expression via TGF-beta in mesangial cells .
9224204	0	TGF-beta	33,41	elastin	17,24	TGF-beta	elastin	7040	2006	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stabilization of elastin mRNA by TGF-beta : initial characterization of signaling pathway .
12370400	0	TGF-beta	0,8	eotaxin-1	44,53	TGF-beta	eotaxin-1	7040	6356	Gene	Gene	increase|nsubj|START_ENTITY increase|dobj|production production|amod|END_ENTITY	TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts .
16428382	0	TGF-beta	85,93	epidermal_growth_factor	25,48	TGF-beta	epidermal growth factor	7040	1950	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Novel permissive role of epidermal_growth_factor in transforming_growth_factor_beta -LRB- TGF-beta -RRB- signaling and growth suppression .
19747910	0	TGF-beta	0,8	fibroblast_activation_protein	17,46	TGF-beta	fibroblast activation protein	7040	2191	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TGF-beta induces fibroblast_activation_protein expression ; fibroblast_activation_protein expression increases the proliferation , adhesion , and migration of HO-8910PM -LSB- corrected -RSB- .
19747910	0	TGF-beta	0,8	fibroblast_activation_protein	59,88	TGF-beta	fibroblast activation protein	7040	2191	Gene	Gene	induces|nsubj|START_ENTITY induces|parataxis|increases increases|nsubj|expression expression|compound|END_ENTITY	TGF-beta induces fibroblast_activation_protein expression ; fibroblast_activation_protein expression increases the proliferation , adhesion , and migration of HO-8910PM -LSB- corrected -RSB- .
11330966	0	TGF-beta	103,111	granulocyte_macrophage-colony_stimulating_factor	29,77	TGF-beta	granulocyte macrophage-colony stimulating factor	7040	1437	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression and action of granulocyte_macrophage-colony_stimulating_factor and its interaction with TGF-beta in endometrial_carcinoma .
10193415	0	TGF-beta	201,209	interferon-gamma	52,68	TGF-beta	interferon-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
7955537	0	TGF-beta	88,96	interferon-gamma	28,44	TGF-beta	interferon-gamma	59086(Tax:10116)	25712(Tax:10116)	Gene	Gene	factor-beta|appos|START_ENTITY factor-beta|compound|IL-4 IL-4|amod|END_ENTITY	Cellular mRNA expression of interferon-gamma , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental_allergic_neuritis .
9099937	0	TGF-beta	100,108	interferon-gamma	28,44	TGF-beta	interferon-gamma	59086(Tax:10116)	25712(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cellular mRNA expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- in rats nasally tolerized against experimental autoimmune_myasthenia_gravis -LRB- EAMG -RRB- .
9916739	0	TGF-beta	0,8	leukotriene_C4_synthase	19,42	TGF-beta	leukotriene C4 synthase	7040	4056	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	TGF-beta increases leukotriene_C4_synthase expression in the monocyte-like cell line , THP-1 .
21324893	0	TGF-beta	0,8	miR-206	19,26	TGF-beta	miR-206	21803(Tax:10090)	387202(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4 .
25183046	0	TGF-beta	0,8	miR-93	74,80	TGF-beta	miR-93	7040	407051	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	TGF-beta induced RBL2 expression in renal_cancer cells by down-regulating miR-93 .
20133617	0	TGF-beta	45,53	microRNA-155	25,37	TGF-beta	microRNA-155	7040	406947	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis .
12185267	0	TGF-beta	82,90	p21	45,48	TGF-beta	p21	7040	644914	Gene	Gene	pathway|amod|START_ENTITY inhibition|nmod|pathway represses|nmod|inhibition represses|dobj|promoter promoter|amod|END_ENTITY	Hepatitis_C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway .
14726675	0	TGF-beta	47,55	p21	0,3	TGF-beta	p21	7040	1026	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- mediates the growth response to TGF-beta in human epithelial cells .
8816905	0	TGF-beta	48,56	p27	27,30	TGF-beta	p27	21803(Tax:10090)	12576(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of p27 and cyclin_D1 by TGF-beta and EGF in C3H 10T1/2 mouse fibroblasts .
16179804	0	TGF-beta	108,116	p300	0,4	TGF-beta	p300	7040	2033	Gene	Gene	signaling|compound|START_ENTITY alteration|nmod|signaling associated|nmod|alteration cells|acl|associated HIV-1|nmod|cells HIV-1|nsubj|modulates modulates|amod|END_ENTITY	p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells : associated with alteration of TGF-beta and Smad signaling .
9813111	0	TGF-beta	62,70	p300	8,12	TGF-beta	p300	7040	2033	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of p300 , a transcriptional coactivator , in signalling of TGF-beta .
10448271	0	TGF-beta	79,87	p53	0,3	TGF-beta	p53	7040	7157	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|mutations mutations|compound|END_ENTITY	p53 gene mutations and p21 protein expression induced independently of p53 , by TGF-beta and gamma-rays in squamous_cell_carcinoma cells .
10448271	0	TGF-beta	79,87	p53	71,74	TGF-beta	p53	7040	7157	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	p53 gene mutations and p21 protein expression induced independently of p53 , by TGF-beta and gamma-rays in squamous_cell_carcinoma cells .
12732139	0	TGF-beta	53,61	p53	33,36	TGF-beta	p53	7040	7157	Gene	Gene	responses|amod|START_ENTITY required|nmod|responses required|nsubjpass|END_ENTITY	Links between tumor suppressors : p53 is required for TGF-beta gene responses by cooperating with Smads .
17234915	0	TGF-beta	15,23	p53	55,58	TGF-beta	p53	7040	7157	Gene	Gene	Integration|nmod|START_ENTITY Integration|acl|signaling signaling|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation .
17875924	0	TGF-beta	136,144	p53	7,10	TGF-beta	p53	7040	7157	Gene	Gene	II|compound|START_ENTITY expression|nmod|II repressing|dobj|expression signaling|advcl|repressing transforming_growth_factor_beta1|acl|signaling attenuates|dobj|transforming_growth_factor_beta1 attenuates|nsubj|END_ENTITY	Mutant p53 attenuates the SMAD-dependent transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- signaling pathway by repressing the expression of TGF-beta receptor type II .
18510920	0	TGF-beta	32,40	p53	0,3	TGF-beta	p53	7040	7157	Gene	Gene	response|amod|START_ENTITY orchestrates|dobj|response orchestrates|nsubj|regulation regulation|compound|END_ENTITY	p53 regulation orchestrates the TGF-beta response .
8119773	0	TGF-beta	55,63	p53	36,39	TGF-beta	p53	7040	7157	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|transduction transduction|nmod|gene gene|compound|END_ENTITY	Retroviral-mediated transduction of p53 gene increases TGF-beta expression in a human glioblastoma cell line .
18035064	0	TGF-beta	0,8	serum_response_factor	22,43	TGF-beta	serum response factor	7040	6722	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	TGF-beta up-regulates serum_response_factor in activated hepatic stellate cells .
19151320	0	TGF-beta	93,101	serum_response_factor	17,38	TGF-beta	serum response factor	7040	6722	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Critical role of serum_response_factor in pulmonary myofibroblast differentiation induced by TGF-beta .
10797313	0	TGF-beta	150,158	smad3	15,20	TGF-beta	smad3	7040	4088	Gene	Gene	required|nmod|START_ENTITY promoter|acl|required _|dobj|promoter _|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of smad3 with a proximal smad-binding element of the human alpha2 -LRB- I -RRB- _ procollagen gene promoter required for transcriptional activation by TGF-beta .
9609460	0	TGF-beta	76,84	thrombospondin	43,57	TGF-beta	thrombospondin	7040	7057	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	The fibronectin production is increased by thrombospondin via activation of TGF-beta in cultured human mesangial cells .
10193412	0	TGF-beta	55,63	transforming_growth_factor-beta	22,53	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of transforming_growth_factor-beta -LRB- TGF-beta -RRB- on certain functions of intraepithelial lymphocytes .
10793000	0	TGF-beta	41,49	transforming_growth_factor-beta	8,39	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Loss of transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptor type I mediates TGF-beta resistance in human_papillomavirus_type_16-transformed human keratinocytes at late stages of in vitro progression .
12675860	0	TGF-beta	48,56	transforming_growth_factor-beta	15,46	TGF-beta	Transforming growth factor-beta	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of transforming_growth_factor-beta -LRB- TGF-beta -RRB- T869C -LRB- Leu_10Pro -RRB- gene polymorphisms with type 2 diabetic_nephropathy in Chinese .
1310325	0	TGF-beta	82,90	transforming_growth_factor-beta	49,80	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Subtypes of betaglycan and of type I and type II transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors with different affinities for TGF-beta_1 and TGF-beta_2 are exhibited by human placental trophoblast cells .
1333844	0	TGF-beta	53,61	transforming_growth_factor-beta	20,51	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Characterization of transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors on BeWo choriocarcinoma cells including the identification of a novel 38-kDa TGF-beta binding glycoprotein .
1433985	0	TGF-beta	98,106	transforming_growth_factor-beta	65,96	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Function , molecular structure and gene expression regulation of transforming_growth_factor-beta -LRB- TGF-beta -RRB- -RSB- .
15808954	0	TGF-beta	61,69	transforming_growth_factor-beta	28,59	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	Functions|appos|START_ENTITY Functions|nmod|END_ENTITY	Functions and regulation of transforming_growth_factor-beta -LRB- TGF-beta -RRB- in the prostate .
16162149	0	TGF-beta	59,67	transforming_growth_factor-beta	21,52	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the transforming_growth_factor-beta gene -LRB- TGF-beta -RRB- and the risk of advanced alcoholic_liver_disease .
1906362	0	TGF-beta	70,78	transforming_growth_factor-beta	37,68	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	-LSB- Immunohistochemical localization of transforming_growth_factor-beta -LRB- TGF-beta -RRB- in smooth muscle tissue -RSB- .
7697928	0	TGF-beta	56,64	transforming_growth_factor-beta	23,54	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	Enhanced production of transforming_growth_factor-beta -LRB- TGF-beta -RRB- during autologous mixed lymphocyte reaction of systemic sclerosis patients .
7721333	0	TGF-beta	46,54	transforming_growth_factor-beta	13,44	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of transforming_growth_factor-beta -LRB- TGF-beta -RRB- on the immunoglobulin production by EBV-infected B cell cultures .
8050825	0	TGF-beta	47,55	transforming_growth_factor-beta	14,45	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Expression of transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors , TGF-beta_1 and TGF-beta_2 production and autocrine growth control in osteosarcoma cells .
8149667	0	TGF-beta	92,100	transforming_growth_factor-beta	59,90	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Increased levels of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming_growth_factor-beta -LRB- TGF-beta -RRB- mRNA expressing blood mononuclear cells in human HIV_infection .
8576191	0	TGF-beta	48,56	transforming_growth_factor-beta	15,46	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Requirement of transforming_growth_factor-beta -LRB- TGF-beta -RRB- type II receptor for TGF-beta-induced proliferation and growth inhibition .
9570266	0	TGF-beta	41,49	transforming_growth_factor-beta	8,39	TGF-beta	transforming growth factor-beta	7040	7040	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Ovarian transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors : in-vitro effects of follicle stimulating hormone , epidermal growth factor and TGF-beta on receptor expression in human preantral follicles .
11984735	0	TGF-beta	47,55	transforming_growth_factor_beta	14,45	TGF-beta	transforming growth factor beta	7040	7040	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of transforming_growth_factor_beta -LRB- TGF-beta -RRB- may contribute , in part , to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric_carcinoma .
12539688	0	TGF-beta	47,55	transforming_growth_factor_beta	15,46	TGF-beta	transforming growth factor beta	7040	7040	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of transforming_growth_factor_beta -LRB- TGF-beta -RRB- subtypes in oral_squamous_cell_carcinoma -RSB- .
14676202	0	TGF-beta	56,64	transforming_growth_factor_beta	23,54	TGF-beta	transforming growth factor beta	7040	7040	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Differential effect of transforming_growth_factor_beta -LRB- TGF-beta -RRB- on the genes encoding hyaluronan synthases and utilization of the p38 MAPK pathway in TGF-beta-induced hyaluronan_synthase_1 activation .
8389483	0	TGF-beta	54,62	transforming_growth_factor_beta	21,52	TGF-beta	transforming growth factor beta	7040	7040	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Growth inhibition by transforming_growth_factor_beta -LRB- TGF-beta -RRB- type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta_receptor_type_II cDNA .
8670764	0	TGF-beta	61,69	transforming_growth_factor_beta	28,59	TGF-beta	transforming growth factor beta	7040	7040	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production and secretion of transforming_growth_factor_beta -LRB- TGF-beta -RRB- by the human lacrimal gland .
12386092	0	TGF-beta	91,99	transglutaminase_2	23,41	TGF-beta	transglutaminase 2	7040	7052	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of transglutaminase_2 in anterior_polar_cataracts and its induction by TGF-beta in vitro .
9933439	0	TGF-beta	60,68	vascular_endothelial_growth_factor	88,122	TGF-beta	vascular endothelial growth factor	7040	7422	Gene	Gene	cytokine|dep|START_ENTITY cytokine|dep|END_ENTITY	Hypoxia augments cytokine -LRB- transforming_growth_factor-beta -LRB- TGF-beta -RRB- and IL-1 -RRB- - induced vascular_endothelial_growth_factor secretion by human synovial fibroblasts .
10471535	0	TGF-beta-1	0,10	cyclin_D1	24,33	TGF-beta-1	cyclin D1	7040	595	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	TGF-beta-1 up-regulates cyclin_D1 expression in COLO-357 cells , whereas suppression of cyclin_D1 levels is associated with down-regulation of the type I TGF-beta receptor .
17651487	0	TGF-beta-1	55,65	transforming_growth_factor_beta-1	20,53	TGF-beta-1	transforming growth factor beta-1	7040	7040	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	` Correction : ' Serum transforming_growth_factor_beta-1 -LRB- TGF-beta-1 -RRB- levels in diabetic patients are not associated with pre-existent coronary_artery_disease .
12767908	0	TGF-beta-stimulated_clone-22	42,70	TSC-22	34,40	TGF-beta-stimulated clone-22	TSC-22	8848	8848	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Posttranscriptional regulation of TSC-22 -LRB- TGF-beta-stimulated_clone-22 -RRB- gene by TGF-beta_1 .
20057170	0	TGF-beta1	0,9	ABCA1	37,42	TGF-beta1	ABCA1	7040	19	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	TGF-beta1 up-regulates expression of ABCA1 , ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
18161870	0	TGF-beta1	20,29	Akt	81,84	TGF-beta1	Akt	7040	207	Gene	Gene	enhance|nsubj|START_ENTITY enhance|nmod|END_ENTITY	Osteoblasts-derived TGF-beta1 enhance motility and integrin upregulation through Akt , ERK , and NF-kappaB-dependent pathway in human breast_cancer cells .
15770925	0	TGF-beta1	45,54	Angiotensin_II	0,14	TGF-beta1	Angiotensin II	7040	183	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Angiotensin_II mediates high glucose-induced TGF-beta1 and fibronectin upregulation in HPMC through reactive oxygen species .
17206447	0	TGF-beta1	76,85	Angiotensin_type_1	0,18	TGF-beta1	Angiotensin type 1	59086(Tax:10116)	24180(Tax:10116)	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Angiotensin_type_1 -LRB- AT1 -RRB- and type 2 -LRB- AT2 -RRB- receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac_hypertrophy .
11027532	0	TGF-beta1	0,9	BRCA1	19,24	TGF-beta1	BRCA1	7040	672	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	TGF-beta1 inhibits BRCA1 expression through a pathway that requires pRb .
19014341	0	TGF-beta1	31,40	C/EBPbeta	53,62	TGF-beta1	C/EBPbeta	7040	1051	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Evidence for activation of the TGF-beta1 promoter by C/EBPbeta and its modulation by Smads .
9862705	0	TGF-beta1	32,41	CBF_alpha3	0,10	TGF-beta1	CBF alpha3	21803(Tax:10090)	12399(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	CBF_alpha3 -LRB- AML2 -RRB- is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter .
15746186	0	TGF-beta1	22,31	CD11b	59,64	TGF-beta1	CD11b	7040	3684	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Inhibitory control of TGF-beta1 on the activation of Rap1 , CD11b , and transendothelial migration of leukocytes .
15016653	0	TGF-beta1	140,149	CD25	90,94	TGF-beta1	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	inflammation|nmod|START_ENTITY inflammation|nmod|suppression suppression|nmod|cells cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
16180248	0	TGF-beta1	0,9	CD25	29,33	TGF-beta1	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	TGF-beta1 production by CD4 + CD25 + regulatory T cells is not essential for suppression of intestinal_inflammation .
10619862	0	TGF-beta1	51,60	CD4	0,3	TGF-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	reverse|nsubj|START_ENTITY produce|ccomp|reverse engineered|xcomp|produce cells|acl|engineered T|dobj|cells T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway_hyperreactivity and inflammation .
15016653	0	TGF-beta1	140,149	CD4	86,89	TGF-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	inflammation|nmod|START_ENTITY inflammation|nmod|suppression suppression|nmod|cells cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15557315	0	TGF-beta1	86,95	CD4	99,102	TGF-beta1	CD4	7040	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Anti-CD28-induced co-stimulation and TCR avidity regulates the differential effect of TGF-beta1 on CD4 + and CD8 + na ve human T-cells .
15809351	0	TGF-beta1	0,9	CD4	64,67	TGF-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	maintains|nsubj|START_ENTITY maintains|dobj|function function|nmod|cells cells|compound|END_ENTITY	TGF-beta1 maintains suppressor function and Foxp3 expression in CD4 + CD25 + regulatory T cells .
16180248	0	TGF-beta1	0,9	CD4	24,27	TGF-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	TGF-beta1 production by CD4 + CD25 + regulatory T cells is not essential for suppression of intestinal_inflammation .
16648238	0	TGF-beta1	0,9	CD4	88,91	TGF-beta1	CD4	7040	920	Gene	Gene	influence|nsubj|START_ENTITY influence|nmod|lymphocytes lymphocytes|compound|END_ENTITY	TGF-beta1 in SP-A preparations influence immune suppressive properties of SP-A on human CD4 + T lymphocytes .
16751781	0	TGF-beta1	80,89	CD4	19,22	TGF-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY pathology|nmod|mice prevents|dobj|pathology prevents|nsubj|Restriction Restriction|nmod|repertoire repertoire|compound|END_ENTITY	Restriction of the CD4 + T-cell receptor repertoire prevents immune pathology in TGF-beta1 knockout mice .
17307871	0	TGF-beta1	21,30	CD4	51,54	TGF-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	differentiate|nummod|START_ENTITY naive|nmod:npmod|differentiate CD25|amod|naive CD25|compound|END_ENTITY	Dendritic cells with TGF-beta1 differentiate naive CD4 + CD25 - T cells into islet-protective Foxp3 + regulatory T cells .
17475784	0	TGF-beta1	0,9	CD4	73,76	TGF-beta1	CD4	7040	920	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|subsets subsets|compound|END_ENTITY	TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4 + T cell subsets .
20081874	0	TGF-beta1	0,9	CD4	114,117	TGF-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	gene-modified|advmod|START_ENTITY delay|ccomp|gene-modified delay|dobj|development development|nmod|cells cells|amod|inflammatory_bowel_disease inflammatory_bowel_disease|nmod|Foxp3 Foxp3|compound|END_ENTITY	TGF-beta1 gene-modified , immature dendritic cells delay the development of inflammatory_bowel_disease by inducing CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
24950027	0	TGF-beta1	138,147	CD4	11,14	TGF-beta1	CD4	7040	920	Gene	Gene	production|nmod|START_ENTITY due|nmod|production inhibit|xcomp|due fail|xcomp|inhibit fail|dep|Cord Cord|dobj|CD25 CD25|compound|END_ENTITY	Cord blood CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells fail to inhibit cord blood NK cell functions due to insufficient production and expression of TGF-beta1 .
9207402	0	TGF-beta1	123,132	CD4	18,21	TGF-beta1	CD4	7040	920	Gene	Gene	activity|dep|START_ENTITY up-regulates|dobj|activity up-regulates|nsubj|engagement engagement|nmod|antigen antigen|compound|END_ENTITY	The engagement of CD4 surface antigen in the HEL haemopoietic cell line up-regulates the transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- promoter activity .
12731064	0	TGF-beta1	0,9	CD95	31,35	TGF-beta1	CD95	7040	355	Gene	Gene	Fas|compound|START_ENTITY Fas|appos|END_ENTITY	TGF-beta1 modulates Fas -LRB- APO-1 / CD95 -RRB- - mediated apoptosis of human pre-B cell lines .
14647065	0	TGF-beta1	30,39	CK2	14,17	TGF-beta1	CK2	21803(Tax:10090)	13000(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes .
16820791	0	TGF-beta1	0,9	COX-2	18,23	TGF-beta1	COX-2	7040	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells .
20375691	0	TGF-beta1	0,9	COX-2	33,38	TGF-beta1	COX-2	7040	4513	Gene	Gene	reverses|nsubj|START_ENTITY reverses|dobj|inhibition inhibition|nmod|END_ENTITY	TGF-beta1 reverses inhibition of COX-2 with NS398 and increases invasion in prostate_cancer cells .
20432467	0	TGF-beta1	57,66	CTGF	39,43	TGF-beta1	CCN2	21803(Tax:10090)	14219(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|acl|induction	Src is a major signaling component for CTGF induction by TGF-beta1 in osteoblasts .
12446007	0	TGF-beta1	0,9	CX3CR1	22,28	TGF-beta1	CX3CR1	59086(Tax:10116)	171056(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia .
19878925	0	TGF-beta1	43,52	ClC-5	0,5	TGF-beta1	ClC-5	21803(Tax:10090)	12728(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	ClC-5 regulates dentin development through TGF-beta1 pathway .
18406048	0	TGF-beta1	0,9	Cx43	19,23	TGF-beta1	Cx43	7040	2697	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TGF-beta1 inhibits Cx43 expression and formation of functional syncytia in cultured smooth muscle cells from human detrusor .
11263983	0	TGF-beta1	77,86	Endoglin	0,8	TGF-beta1	Endoglin	59086(Tax:10116)	2022	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Endoglin expression in human and rat mesangial cells and its upregulation by TGF-beta1 .
17587163	0	TGF-beta1	39,48	Eosinophil_cationic_protein	0,27	TGF-beta1	Eosinophil cationic protein	7040	6037	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Eosinophil_cationic_protein stimulates TGF-beta1 release by human lung fibroblasts in vitro .
26051800	0	TGF-beta1	60,69	Fibulin-2	0,9	TGF-beta1	Fibulin-2	59086(Tax:10116)	282583(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY mediator|nmod|effect mediator|nsubj|END_ENTITY	Fibulin-2 is a key mediator of the pro-neurogenic effect of TGF-beta1 on adult neural stem cells .
20307666	0	TGF-beta1	35,44	FoxP3	137,142	TGF-beta1	FoxP3	7040	50943	Gene	Gene	synergize|nsubj|START_ENTITY synergize|xcomp|suppress suppress|dobj|responses responses|nmod|upregulation upregulation|nmod|Tregs Tregs|compound|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta1 -RRB- and rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3 + Tregs .
16918480	0	TGF-beta1	4,13	Foxp3	14,19	TGF-beta1	Foxp3	7040	50943	Gene	Gene	START_ENTITY|dep|axis axis|amod|END_ENTITY	The TGF-beta1 / Foxp3 regulatory axis in immune self-tolerance : implications for health and disease .
17307871	0	TGF-beta1	21,30	Foxp3	91,96	TGF-beta1	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	differentiate|nummod|START_ENTITY naive|nmod:npmod|differentiate CD25|amod|naive cells|nmod|CD25 cells|dep|cells cells|nmod|cells cells|compound|END_ENTITY	Dendritic cells with TGF-beta1 differentiate naive CD4 + CD25 - T cells into islet-protective Foxp3 + regulatory T cells .
17475784	0	TGF-beta1	0,9	Foxp3	20,25	TGF-beta1	Foxp3	7040	50943	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4 + T cell subsets .
19079658	0	TGF-beta1	21,30	Foxp3	61,66	TGF-beta1	Foxp3	7040	50943	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Cells Cells|compound|END_ENTITY	The Critical Role of TGF-beta1 in the Development of Induced Foxp3 + Regulatory T Cells .
20081874	0	TGF-beta1	0,9	Foxp3	120,125	TGF-beta1	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	gene-modified|advmod|START_ENTITY delay|ccomp|gene-modified delay|dobj|development development|nmod|cells cells|amod|inflammatory_bowel_disease inflammatory_bowel_disease|nmod|END_ENTITY	TGF-beta1 gene-modified , immature dendritic cells delay the development of inflammatory_bowel_disease by inducing CD4 -LRB- + -RRB- Foxp3 -LRB- + -RRB- regulatory T cells .
17113629	0	TGF-beta1	73,82	GAGEC1	0,6	TGF-beta1	GAGEC1	7040	9506	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	GAGEC1 , a cancer/testis associated antigen family member , is a target of TGF-beta1 in age-related prostatic_disease .
18346908	0	TGF-beta1	0,9	GSK-3beta	22,31	TGF-beta1	GSK-3beta	7040	2932	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	TGF-beta1 targets the GSK-3beta / beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts .
20599907	0	TGF-beta1	52,61	Glycogen_synthase_kinase-3beta	0,30	TGF-beta1	Glycogen synthase kinase-3beta	7040	2932	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta negatively regulates TGF-beta1 and Angiotensin_II-mediated cellular activity through interaction with Smad3 .
12376363	0	TGF-beta1	0,9	HO-1	21,25	TGF-beta1	HO-1	7040	3162	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	TGF-beta1 stimulates HO-1 via the p38_mitogen-activated_protein_kinase in A549 pulmonary epithelial cells .
17357279	0	TGF-beta1	0,9	ICAM-1	25,31	TGF-beta1	ICAM-1	7040	3383	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	TGF-beta1 down-regulates ICAM-1 expression and enhances liver metastasis of pancreatic_cancer .
11991675	0	TGF-beta1	43,52	IFN-gamma	32,41	TGF-beta1	IFN-gamma	7040	3458	Gene	Gene	START_ENTITY|nsubj|Production Production|nmod|END_ENTITY	Production of IL-10 , TNF-alpha , IFN-gamma , TGF-beta1 by different populations of erythroid cells derived from human embryonal liver .
16237056	0	TGF-beta1	0,9	IFN-gamma	38,47	TGF-beta1	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4 + T cells through the protein tyrosine phosphatase Src_homology_region_2_domain-containing_phosphatase-1 .
16688597	0	TGF-beta1	22,31	IFN-gamma	48,57	TGF-beta1	IFN-gamma	7040	3458	Gene	Gene	START_ENTITY|ccomp|patients patients|nsubj|levels levels|compound|END_ENTITY	Increased intrathecal TGF-beta1 , but not IL-12 , IFN-gamma and IL-10 levels in Alzheimer 's _ disease patients .
19414763	0	TGF-beta1	27,36	IFN-gamma	94,103	TGF-beta1	IFN-gamma	7040	3458	Gene	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of membrane-bound TGF-beta1 and its regulation by IL-2-activated immune cell-derived IFN-gamma in head_and_neck_squamous_cell_carcinoma cell lines .
8608649	0	TGF-beta1	35,44	IFN-gamma	197,206	TGF-beta1	IFN-gamma	7040	3458	Gene	Gene	Transforming_growth_factor-beta_1|appos|START_ENTITY Transforming_growth_factor-beta_1|dep|inhibition inhibition|nmod|cell cell|acl:relcl|interrupted interrupted|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- - mediated inhibition of glial cell proliferation and down-regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- are interrupted by interferon-gamma -LRB- IFN-gamma -RRB- .
9843764	0	TGF-beta1	95,104	IGFBP-3	0,7	TGF-beta1	IGFBP-3	7040	3486	Gene	Gene	regulation|nmod|START_ENTITY production|dep|regulation production|amod|END_ENTITY	IGFBP-3 and IGFBP-5 production by human intestinal muscle : reciprocal regulation by endogenous TGF-beta1 .
15622443	0	TGF-beta1	11,20	IL-10	22,27	TGF-beta1	IL-10	7040	3586	Gene	Gene	IL-6|amod|START_ENTITY IL-6|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
18231731	0	TGF-beta1	10,19	IL-12	41,46	TGF-beta1	IL-12	59086(Tax:10116)	64546(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of TGF-beta1 on the expression of IL-12 , IL-15 , IL-18 , IL-4 and IL-10 in heart transplantation rejection in rats .
19110334	0	TGF-beta1	75,84	IL-18	12,17	TGF-beta1	IL-18	7040	3606	Gene	Gene	expression|amod|START_ENTITY expression|dep|expression expression|compound|END_ENTITY	Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy : TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells .
19110334	0	TGF-beta1	75,84	IL-18	94,99	TGF-beta1	IL-18	7040	3606	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy : TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells .
16696320	0	TGF-beta1	36,45	IL-5	0,4	TGF-beta1	IL-5	7040	3567	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	IL-5 up-regulates the expression of TGF-beta1 in human blood eosinophils in vitro .
10893219	0	TGF-beta1	0,9	IL-8	21,25	TGF-beta1	IL-8	7040	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	TGF-beta1 stimulates IL-8 release , COX-2 expression , and PGE -LRB- 2 -RRB- release in human airway_smooth_muscle cells .
16204411	0	TGF-beta1	0,9	IL-8	18,22	TGF-beta1	IL-8	7040	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	TGF-beta1 induces IL-8 and MCP-1 through a connective_tissue_growth_factor-independent pathway .
18435575	0	TGF-beta1	19,28	IL-8	40,44	TGF-beta1	IL-8	21803(Tax:10090)	20309(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Osteoblast-derived TGF-beta1 stimulates IL-8 release through AP-1 and NF-kappaB in human cancer cells .
9844046	0	TGF-beta1	160,169	IL-8	48,52	TGF-beta1	IL-8	7040	3576	Gene	Gene	transforming_growth_factor-beta_1|appos|START_ENTITY role|nmod|transforming_growth_factor-beta_1 cells|dep|role cells|dep|expression expression|compound|END_ENTITY	Human intestinal epithelial cells down-regulate IL-8 expression in human intestinal microvascular endothelial cells ; role of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- .
16223775	0	TGF-beta1	55,64	Id2	37,40	TGF-beta1	Id2	7040	3398	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Differential involvement of PU .1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment .
9570721	0	TGF-beta1	115,124	Interleukin-1beta	0,17	TGF-beta1	Interleukin-1beta	59086(Tax:10116)	24494(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Interleukin-1beta system -LRB- ligand , receptor type I , receptor accessory protein and receptor antagonist -RRB- , TNF-alpha , TGF-beta1 and neuropeptide_Y mRNAs in specific brain regions during bacterial LPS-induced anorexia .
15260968	0	TGF-beta1	52,61	JNK	0,3	TGF-beta1	JNK	7040	5599	Gene	Gene	signaling|nmod|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	JNK regulates expression and autocrine signaling of TGF-beta1 .
15260977	0	TGF-beta1	38,47	JNK	0,3	TGF-beta1	JNK	21803(Tax:10090)	26419(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	JNK regulates autocrine expression of TGF-beta1 .
16223572	0	TGF-beta1	47,56	LTBP-3	19,25	TGF-beta1	LTBP-3	7040	4054	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements .
10025676	0	TGF-beta1	49,58	LTBP1	32,37	TGF-beta1	LTBP1	59086(Tax:10116)	59107(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Vitamin_D3 metabolites regulate LTBP1 and latent TGF-beta1 expression and latent TGF-beta1 incorporation in the extracellular matrix of chondrocytes .
18704440	0	TGF-beta1	44,53	MCP-1	35,40	TGF-beta1	MCP-1	7040	6347	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of mRNA expression of MCP-1 by TGF-beta1 in fibroblast cells from Peyronie 's _ disease .
9856953	0	TGF-beta1	32,41	MDM2	24,28	TGF-beta1	MDM2	7040	4193	Gene	Gene	resistance|compound|START_ENTITY role|nmod|resistance role|nmod|END_ENTITY	p53-independent role of MDM2 in TGF-beta1 resistance .
16690877	0	TGF-beta1	75,84	Matrix_metalloproteinase_2	0,26	TGF-beta1	Matrix metalloproteinase 2	59086(Tax:10116)	81686(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Matrix_metalloproteinase_2 activation of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- and TGF-beta1-type_II_receptor signaling within the aged arterial wall .
10388535	0	TGF-beta1	0,9	NF-kappaB	19,28	TGF-beta1	NF-kappaB	7040	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	TGF-beta1 inhibits NF-kappaB activity through induction of IkappaB-alpha expression in human salivary gland cells : a possible mechanism of growth suppression by TGF-beta1 .
10388535	0	TGF-beta1	161,170	NF-kappaB	19,28	TGF-beta1	NF-kappaB	7040	4790	Gene	Gene	suppression|nmod|START_ENTITY mechanism|nmod|suppression inhibits|parataxis|mechanism inhibits|dobj|activity activity|amod|END_ENTITY	TGF-beta1 inhibits NF-kappaB activity through induction of IkappaB-alpha expression in human salivary gland cells : a possible mechanism of growth suppression by TGF-beta1 .
12545162	0	TGF-beta1	71,80	NF-kappaB	24,33	TGF-beta1	NF-kappaB	21803(Tax:10090)	18033(Tax:10090)	Gene	Gene	AP-1|compound|START_ENTITY activation|nmod|AP-1 activation|nmod|END_ENTITY	Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1 / SMAD signaling and apoptosis : implications in liver_tumor formation .
16565440	10	TGF-beta1	1700,1709	NF-kappaB	1730,1739	NF-kappaB	TGF-beta1	18033(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	In the RAW264 .7 line , SbG and baicalin stimulated TGF-beta1 gene expression via NF-kappaB and protein kinase C activation .
16690986	0	TGF-beta1	36,45	NF-kappaB	90,99	TGF-beta1	NF-kappaB	7040	4790	Gene	Gene	secretion|compound|START_ENTITY induces|dobj|secretion induces|nmod|muscle muscle|nmod|pathway pathway|amod|END_ENTITY	Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway .
18983820	0	TGF-beta1	118,127	NF-kappaB	23,32	TGF-beta1	NF-kappaB	7040	4790	Gene	Gene	play|nmod|START_ENTITY play|nsubj|Nuclear-factor-kappaB Nuclear-factor-kappaB|appos|END_ENTITY	Nuclear-factor-kappaB -LRB- NF-kappaB -RRB- and radical oxygen species play contrary roles in transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- - induced apoptosis_in_hepatocellular_carcinoma -LRB- HCC -RRB- cells .
15187109	0	TGF-beta1	9,18	NKG2D	52,57	TGF-beta1	NKG2D	7040	22914	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients .
18500388	0	TGF-beta1	24,33	Neuropeptide_Y	0,14	TGF-beta1	Neuropeptide Y	21803(Tax:10090)	109648(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	Neuropeptide_Y promotes TGF-beta1 production in RAW264 .7 cells by activating PI3K pathway via Y1 receptor .
16970923	0	TGF-beta1	50,59	OSAD	41,45	TGF-beta1	OSAD	7040	4958	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of osteoadherin -LRB- OSAD -RRB- by TGF-beta1 and BMP-2 .
16139837	0	TGF-beta1	55,64	PAI-1	77,82	TGF-beta1	PAI-1	282089(Tax:9913)	281375(Tax:9913)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Identification of intracellular pathways through which TGF-beta1 upregulates PAI-1 expression in endothelial cells .
17047299	0	TGF-beta1	4,13	PAI-1	52,57	TGF-beta1	PAI-1	7040	5054	Gene	Gene	START_ENTITY|dep|stimulatory stimulatory|dep|gene gene|compound|END_ENTITY	The TGF-beta1 / upstream stimulatory factor-regulated PAI-1 gene : potential involvement and a therapeutic target in Alzheimer 's _ disease .
17328891	0	TGF-beta1	14,23	PAI-1	38,43	TGF-beta1	PAI-1	7040	5054	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|compound|END_ENTITY	Regulation of TGF-beta1 / MAPK-mediated PAI-1 gene expression by the actin cytoskeleton in human mesangial cells .
17515947	0	TGF-beta1	46,55	PAI-1	0,5	TGF-beta1	PAI-1	7040	5054	Gene	Gene	Regulator|nmod|START_ENTITY Regulator|nsubj|END_ENTITY	PAI-1 is a Critical Upstream Regulator of the TGF-beta1 / EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous_Squamous_Cell_Carcinoma .
19383899	0	TGF-beta1	0,9	PAI-1	162,167	TGF-beta1	PAI-1	7040	5054	Gene	Gene	potential|compound|START_ENTITY coupled|nsubjpass|potential coupled|nmod|plasmin/MMP plasmin/MMP|dep|axis axis|dep|role role|nmod|END_ENTITY	TGF-beta1 + EGF-initiated invasive potential in transformed human keratinocytes is coupled to a plasmin/MMP -10 / MMP-1-dependent collagen remodeling axis : role for PAI-1 .
20428185	0	TGF-beta1	19,28	PAI-1	0,5	TGF-beta1	PAI-1	7040	5054	Gene	Gene	response|amod|START_ENTITY mediates|dobj|response mediates|nsubj|END_ENTITY	PAI-1 mediates the TGF-beta1 + EGF-induced `` scatter '' response in transformed human keratinocytes .
24962629	0	TGF-beta1	0,9	PAI-1	73,78	TGF-beta1	PAI-1	21803(Tax:10090)	18787(Tax:10090)	Gene	Gene	Plasmin|compound|START_ENTITY Plasmin|nmod|Cells Cells|nmod|END_ENTITY	TGF-beta1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1 : Implications for Scarless Flexor Tendon Repair .
16115815	0	TGF-beta1	32,41	PP2A	50,54	TGF-beta1	PP2A	7040	5524	Gene	Gene	START_ENTITY|acl|induced induced|dobj|END_ENTITY	A-type lamins are essential for TGF-beta1 induced PP2A to dephosphorylate transcription factors .
18188456	0	TGF-beta1	15,24	Pin1	0,4	TGF-beta1	Pin1	7040	5300	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic_lung_fibrosis .
16564576	0	TGF-beta1	34,43	RANTES	77,83	TGF-beta1	RANTES	7040	6352	Gene	Gene	Transforming_growth_factor_beta_1|appos|START_ENTITY down-regulates|nsubj|Transforming_growth_factor_beta_1 down-regulates|dobj|production production|compound|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta1 -RRB- down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression .
21189258	0	TGF-beta1	51,60	RANTES	30,36	TGF-beta1	RANTES	7040	6352	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen_synthase_kinase-3beta-dependent beta-catenin signaling .
17920684	0	TGF-beta1	67,76	SOCS3	0,5	TGF-beta1	SOCS3	7040	9021	Gene	Gene	signaling|compound|START_ENTITY promotes|nmod|signaling promotes|nsubj|END_ENTITY	SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1 / Smad3 signaling .
11960349	0	TGF-beta1	65,74	STAT3	31,36	TGF-beta1	STAT3	7040	6774	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and - independent processes .
21156809	0	TGF-beta1	33,42	Sca-1	0,5	TGF-beta1	Sca-1	21803(Tax:10090)	110454(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Sca-1 is negatively regulated by TGF-beta1 in myogenic cells .
10505717	0	TGF-beta1	48,57	Smad2	18,23	TGF-beta1	Smad2	7040	4087	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Smad2 and colocalization with TGF-beta1 in human pancreatic_cancer .
14617750	0	TGF-beta1	23,32	Smad3	33,38	TGF-beta1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	disruption|nmod|START_ENTITY disruption|parataxis|protects protects|nsubj|signaling signaling|compound|END_ENTITY	Targeted disruption of TGF-beta1 / Smad3 signaling protects against renal tubulointerstitial_fibrosis induced by unilateral_ureteral_obstruction .
15240683	0	TGF-beta1	0,9	Smad3	67,72	TGF-beta1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	disrupts|amod|START_ENTITY endotoxin|nsubj|disrupts endotoxin|xcomp|signaling signaling|nmod|END_ENTITY	TGF-beta1 disrupts endotoxin signaling in microglial cells through Smad3 and MAPK pathways .
15629128	0	TGF-beta1	15,24	Smad3	0,5	TGF-beta1	Smad3	7040	4088	Gene	Gene	induction|compound|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts .
16341574	0	TGF-beta1	98,107	Smad3	0,5	TGF-beta1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY induced|nmod|cells matrix|acl|induced expression|nmod|matrix decreases|dobj|expression decreases|nsubj|inhibitor inhibitor|amod|END_ENTITY	Smad3 specific inhibitor , naringenin , decreases the expression of extracellular matrix induced by TGF-beta1 in cultured rat hepatic stellate cells .
16371439	0	TGF-beta1	23,32	Smad3	54,59	TGF-beta1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	loop|nmod|START_ENTITY loop|nmod|END_ENTITY	Autocrine loop between TGF-beta1 and IL-1beta through Smad3 - and ERK-dependent pathways in rat pancreatic stellate cells .
17920684	0	TGF-beta1	67,76	Smad3	77,82	TGF-beta1	Smad3	7040	4088	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1 / Smad3 signaling .
20599907	0	TGF-beta1	52,61	Smad3	133,138	TGF-beta1	Smad3	7040	4088	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nmod|interaction interaction|nmod|END_ENTITY	Glycogen_synthase_kinase-3beta negatively regulates TGF-beta1 and Angiotensin_II-mediated cellular activity through interaction with Smad3 .
21560355	0	TGF-beta1	24,33	Smad3	34,39	TGF-beta1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|pathway pathway|amod|END_ENTITY	-LSB- Effects of sericine on TGF-beta1 / Smad3 signal pathway of diabetic mephropathy rats kidney -RSB- .
23627095	0	TGF-beta1	44,53	Smad3	54,59	TGF-beta1	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|parataxis|-RSB- -RSB-|nsubj|pathway pathway|amod|END_ENTITY	-LSB- Effect of Huangqi gegen decoction -LRB- HGD -RRB- on TGF-beta1 / Smad3 pathway in diabetic_cardiomyopathy rats -RSB- .
12860278	0	TGF-beta1	22,31	Smad4	46,51	TGF-beta1	Smad4	7040	4089	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Aberrant signaling of TGF-beta1 by the mutant Smad4 in gastric_cancer cells .
11518734	0	TGF-beta1	24,33	Smad7	9,14	TGF-beta1	Smad7	7040	4092	Gene	Gene	restores|dobj|START_ENTITY restores|nsubj|END_ENTITY	Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory_bowel_disease .
16237056	0	TGF-beta1	0,9	Src_homology_region_2_domain-containing_phosphatase-1	112,165	TGF-beta1	Src homology region 2 domain-containing phosphatase-1	21803(Tax:10090)	15170(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4 + T cells through the protein tyrosine phosphatase Src_homology_region_2_domain-containing_phosphatase-1 .
16237056	0	TGF-beta1	0,9	T-bet	19,24	TGF-beta1	T-bet	21803(Tax:10090)	57765(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|amod|END_ENTITY	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4 + T cells through the protein tyrosine phosphatase Src_homology_region_2_domain-containing_phosphatase-1 .
12032227	0	TGF-beta1	0,9	TGF-beta1	20,29	TGF-beta1	TGF-beta1	7040	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing .
12032227	0	TGF-beta1	20,29	TGF-beta1	0,9	TGF-beta1	TGF-beta1	7040	7040	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing .
20021864	0	TGF-beta1	15,24	TGF-beta1	85,94	TGF-beta1	TGF-beta1	7040	7040	Gene	Gene	Expression|nmod|START_ENTITY induced|nsubj|Expression induced|nmod|END_ENTITY	-LSB- Expression of TGF-beta1 and the mechanism of invasiveness and metastasis induced by TGF-beta1 in breast_cancer -RSB- .
20021864	0	TGF-beta1	85,94	TGF-beta1	15,24	TGF-beta1	TGF-beta1	7040	7040	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of TGF-beta1 and the mechanism of invasiveness and metastasis induced by TGF-beta1 in breast_cancer -RSB- .
15532825	0	TGF-beta1	49,58	TGF-beta_receptor_type_II	82,107	TGF-beta1	TGF-beta receptor type II	7040	7048	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	Serum level of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- and the expression of TGF-beta_receptor_type_II in peripheral blood mononuclear cells in patients with autoimmune_hepatitis .
11394717	0	TGF-beta1	10,19	TNF-alpha	90,99	TGF-beta1	TNF-alpha	59086(Tax:10116)	21926(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|mice mice|amod|END_ENTITY	Increased TGF-beta1 in the lungs of asbestos-exposed rats and mice : reduced expression in TNF-alpha receptor knockout mice .
11669584	0	TGF-beta1	104,113	TNF-alpha	197,206	TGF-beta1	TNF-alpha	7040	280943(Tax:9913)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|acl|stimulated stimulated|nmod|END_ENTITY	Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha .
11991675	0	TGF-beta1	43,52	TNF-alpha	21,30	TGF-beta1	TNF-alpha	7040	7124	Gene	Gene	START_ENTITY|nsubj|Production Production|nmod|IFN-gamma IFN-gamma|appos|END_ENTITY	Production of IL-10 , TNF-alpha , IFN-gamma , TGF-beta1 by different populations of erythroid cells derived from human embryonal liver .
12431778	0	TGF-beta1	0,9	TNF-alpha	48,57	TGF-beta1	TNF-alpha	21803(Tax:10090)	21926(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|caspases caspases|acl|induced induced|nmod|END_ENTITY	TGF-beta1 inhibits multiple caspases induced by TNF-alpha in murine osteoblastic MC3T3-E1 cells .
15622443	0	TGF-beta1	11,20	TNF-alpha	0,9	TGF-beta1	TNF-alpha	7040	7124	Gene	Gene	IL-6|amod|START_ENTITY polymorphisms|amod|IL-6 polymorphisms|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
19301076	0	TGF-beta1	0,9	TNF-alpha	23,32	TGF-beta1	TNF-alpha	7040	7124	Gene	Gene	influence|nsubj|START_ENTITY influence|nmod|production production|amod|END_ENTITY	TGF-beta1 influence on TNF-alpha production and sTNF-Rs shedding in a coculture of colon_carcinoma cell spheroids with normal cells .
20141610	0	TGF-beta1	18,27	TNF-alpha	0,9	TGF-beta1	TNF-alpha	7040	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation .
9469470	0	TGF-beta1	110,119	TNF-alpha	85,94	TGF-beta1	TNF-alpha	21803(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Increased mortality , blunted production of nitric_oxide , and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic_mice .
9570721	0	TGF-beta1	115,124	TNF-alpha	104,113	TGF-beta1	TNF-alpha	59086(Tax:10116)	24835(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Interleukin-1beta system -LRB- ligand , receptor type I , receptor accessory protein and receptor antagonist -RRB- , TNF-alpha , TGF-beta1 and neuropeptide_Y mRNAs in specific brain regions during bacterial LPS-induced anorexia .
18293192	0	TGF-beta1	14,23	TSP-1	49,54	TGF-beta1	TSP-1	7040	7057	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic_acid in retinal pigment epithelial cells .
18555217	0	TGF-beta1	28,37	TSP-1	76,81	TGF-beta1	TSP-1	7040	7057	Gene	Gene	START_ENTITY|acl|mediating mediating|dobj|effects effects|nmod|END_ENTITY	Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells , fibroblasts and oral tumour cells .
18097622	0	TGF-beta1	14,23	TbetaR_I	48,56	TGF-beta1	TbetaR I	7040	7046	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of TGF-beta1 and its receptor genes -LRB- TbetaR_I , TbetaR_II , and TbetaR_III-betaglycan -RRB- in peripheral blood leucocytes in patients with idiopathic_pulmonary_arterial_hypertension and Eisenmenger 's _ syndrome .
15629128	0	TGF-beta1	15,24	VEGF	38,42	TGF-beta1	VEGF	7040	7422	Gene	Gene	induction|compound|START_ENTITY induction|nmod|production production|amod|END_ENTITY	Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts .
15640959	0	TGF-beta1	150,159	VEGF	115,119	TGF-beta1	VEGF	7040	7422	Gene	Gene	factor|appos|START_ENTITY transforming|dobj|factor alterations|acl|transforming alterations|amod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|dep|END_ENTITY	Early nuclear alterations and immunohistochemical expression of Ki-67 , Erb-B2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , transforming growth factor -LRB- TGF-beta1 -RRB- and integrine-linked kinase -LRB- ILK -RRB- two days after tamoxifen in breast_carcinoma .
15821013	0	TGF-beta1	87,96	VEGF	25,29	TGF-beta1	VEGF	443417(Tax:9940)	443103(Tax:9940)	Gene	Gene	species|amod|START_ENTITY cells|nmod|species END_ENTITY|nmod|cells	Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species : a requirement for NAD -LRB- P -RRB- H oxidase .
17088559	0	TGF-beta1	49,58	VEGF	0,4	TGF-beta1	VEGF	7040	7422	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	VEGF , a prosurvival factor , acts in concert with TGF-beta1 to induce endothelial cell apoptosis .
18057050	0	TGF-beta1	26,35	VEGF	14,18	TGF-beta1	VEGF	21803(Tax:10090)	22339(Tax:10090)	Gene	Gene	production|compound|START_ENTITY blocks|dobj|production blocks|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of VEGF blocks TGF-beta1 production through a PI3K/Akt signalling pathway .
19180561	0	TGF-beta1	35,44	VEGF	111,115	TGF-beta1	VEGF	7040	7422	Gene	Gene	Transforming_growth_factor-beta_1|appos|START_ENTITY induces|nsubj|Transforming_growth_factor-beta_1 induces|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- induces angiogenesis through vascular_endothelial_growth_factor -LRB- VEGF -RRB- - mediated apoptosis .
24941819	0	TGF-beta1	27,36	VEGF	54,58	TGF-beta1	VEGF	7040	7422	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	-LSB- Down-regulation effect of TGF-beta1 on expression of VEGF in bladder_cancer cell line -RSB- .
18005096	0	TGF-beta1	178,187	alpha-SMA	27,36	TGF-beta1	alpha-SMA	59086(Tax:10116)	25365(Tax:10116)	Gene	Gene	transforming_growth_factor-beta_1|appos|START_ENTITY role|nmod|transforming_growth_factor-beta_1 Alpha-smooth_muscle_actin|dep|role Alpha-smooth_muscle_actin|appos|END_ENTITY	Alpha-smooth_muscle_actin -LRB- alpha-SMA -RRB- and nestin expression in reactive astrocytes in multiple_sclerosis lesions : potential regulatory role of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- .
18386047	0	TGF-beta1	76,85	alpha-SMA	55,64	TGF-beta1	alpha-SMA	59086(Tax:10116)	25365(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	HGF suppresses the production of collagen type III and alpha-SMA induced by TGF-beta1 in healing fibroblasts .
18651839	0	TGF-beta1	34,43	androgen_receptor	56,73	TGF-beta1	androgen receptor	7040	367	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Transcriptional regulation of the TGF-beta1 promoter by androgen_receptor .
17169354	0	TGF-beta1	8,17	angiotensin_II	70,84	TGF-beta1	angiotensin II	59086(Tax:10116)	24179(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of TGF-beta1 in vascular smooth muscle cell apoptosis induced by angiotensin_II .
10411682	0	TGF-beta1	0,9	bFGF	47,51	TGF-beta1	bFGF	7040	2247	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	TGF-beta1 stimulates the release of pre-formed bFGF from renal proximal tubular cells .
16095497	0	TGF-beta1	21,30	bFGF	31,35	TGF-beta1	bFGF	7040	2247	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Differential role of TGF-beta1 / bFGF and ET-1 in graft fibrosis in heart_failure patients .
16463783	0	TGF-beta1	50,59	bFGF	61,65	TGF-beta1	bFGF	7040	2247	Gene	Gene	expression|nmod|START_ENTITY -LSB-|nmod|expression procollagen|advcl|-LSB- procollagen|nsubj|END_ENTITY	-LSB- The influence of adrenaline on the expression of TGF-beta1 , bFGF and I procollagen for hypertrophic_scar -RSB- .
15462102	0	TGF-beta1	94,103	bcl-2	41,46	TGF-beta1	bcl-2	7040	596	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Expression of apoptosis-related proteins bcl-2 and bax along with transforming growth factor -LRB- TGF-beta1 -RRB- in the kidney of patients with glomerulonephritides .
11824477	0	TGF-beta1	0,9	connexin43	37,47	TGF-beta1	connexin43	282089(Tax:9913)	281193(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|accumulation accumulation|nmod|END_ENTITY	TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in endothelial cells .
19781809	0	TGF-beta1	0,9	connexin_43	25,36	TGF-beta1	connexin 43	59086(Tax:10116)	24392(Tax:10116)	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	TGF-beta1 down-regulates connexin_43 expression and gap junction intercellular communication in rat hepatic stellate cells .
16964650	0	TGF-beta1	57,66	decorin	46,53	TGF-beta1	decorin	7040	1634	Gene	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	-LSB- The antagonistic effect of recombinant human decorin on TGF-beta1 stimulation of fibroblasts in collagen lattices -RSB- .
16907850	0	TGF-beta1	61,70	endoglin	49,57	TGF-beta1	endoglin	7040	2022	Gene	Gene	co-receptor|compound|START_ENTITY END_ENTITY|appos|co-receptor	Increased intrahepatic and circulating levels of endoglin , a TGF-beta1 co-receptor , in patients with chronic_hepatitis_C_virus_infection : relationship to histological and serum markers of hepatic_fibrosis .
19193655	0	TGF-beta1	0,9	hENT1	46,51	TGF-beta1	hENT1	7040	2030	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	TGF-beta1 inhibits expression and activity of hENT1 in a nitric_oxide-dependent manner in human umbilical vein endothelium .
24135912	0	TGF-beta1	68,77	high_temperature_requirement_A1	13,44	TGF-beta1	high temperature requirement A1	21803(Tax:10090)	56213(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of high_temperature_requirement_A1 , a serine_protease , by TGF-beta1 in articular chondrocytes of mouse models of OA .
17255955	0	TGF-beta1	61,70	karyopherin_alpha_2	27,46	TGF-beta1	karyopherin alpha 2	7040	3838	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Differential regulation of karyopherin_alpha_2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes : evident contribution of KPNA2 for nuclear translocation of IRF-1 .
17395448	0	TGF-beta1	102,111	lysyl_oxidase	85,98	TGF-beta1	lysyl oxidase	7040	4015	Gene	Gene	effects|compound|START_ENTITY END_ENTITY|nmod|effects	Regulation of elastin promoter by lysyl_oxidase and growth factors : cross control of lysyl_oxidase on TGF-beta1 effects .
22007481	0	TGF-beta1	54,63	mannose_binding_lectin	14,36	TGF-beta1	mannose binding lectin	7040	4153	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Influence of mannose_binding_lectin to expression of TGF-beta1 and NF-kappaB in high concentration of glucose cultured human renal glomerular endothelial cells -RSB- .
15246963	0	TGF-beta1	0,9	matrix_metalloproteinase-13	20,47	TGF-beta1	matrix metalloproteinase-13	7040	4322	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	TGF-beta1 modulates matrix_metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK , PI3-kinase , AKT , and p70S6k .
15662627	0	TGF-beta1	11,20	matrix_metalloproteinase-13	68,95	TGF-beta1	matrix metalloproteinase-13	7040	4322	Gene	Gene	expression|compound|START_ENTITY correlated|nsubjpass|expression correlated|nmod|up-regulation up-regulation|nmod|treatment treatment|amod|END_ENTITY	Suppressed TGF-beta1 expression is correlated with up-regulation of matrix_metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment .
15930146	0	TGF-beta1	0,9	monocyte_chemoattractant_protein-1	21,55	TGF-beta1	monocyte chemoattractant protein-1	7040	6347	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	TGF-beta1 stimulates monocyte_chemoattractant_protein-1 expression in mesangial cells through a phosphodiesterase_isoenzyme_4-dependent process .
16970923	0	TGF-beta1	50,59	osteoadherin	27,39	TGF-beta1	osteoadherin	7040	4958	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of osteoadherin -LRB- OSAD -RRB- by TGF-beta1 and BMP-2 .
12939231	0	TGF-beta1	16,25	protein_kinase_C-alpha	108,130	TGF-beta1	protein kinase C-alpha	21803(Tax:10090)	18750(Tax:10090)	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein_kinase_C-alpha .
14769885	0	TGF-beta1	71,80	transforming_growth_factor-beta1	37,69	TGF-beta1	transforming growth factor-beta1	7040	7040	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Hepatitis_B virus X antigen promotes transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- activity by up-regulation of TGF-beta1 and down-regulation of alpha2-macroglobulin .
15288191	0	TGF-beta1	84,93	transforming_growth_factor-beta1	50,82	TGF-beta1	transforming growth factor-beta1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The promoter region -LRB- -800 , -509 -RRB- polymorphisms of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- gene and recurrent spontaneous_abortion .
9792792	0	TGF-beta1	104,113	transforming_growth_factor-beta1	70,102	TGF-beta1	transforming growth factor-beta1	7040	7040	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Upregulated expression of fibroblast growth factor -LRB- FGF -RRB- receptors by transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts .
11730838	0	TGF-beta1	47,56	transforming_growth_factor-beta_1	12,45	TGF-beta1	transforming growth factor-beta 1	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- expression in human monocytes infected with Mycobacterium_avium at a single cell level by ELISPOT assay .
12358852	0	TGF-beta1	75,84	transforming_growth_factor-beta_1	40,73	TGF-beta1	transforming growth factor-beta 1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in codons 10 and 25 of the transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- gene in patients with invasive squamous_cell_carcinoma_of_the_uterine_cervix .
9717976	0	TGF-beta1	112,121	transforming_growth_factor-beta_1	77,110	TGF-beta1	transforming growth factor-beta 1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Aminoguanidine reduces glomerular inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice .
15481772	0	TGF-beta1	67,76	transforming_growth_factor_beta1	33,65	TGF-beta1	transforming growth factor beta1	7040	7040	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Reduced plasma concentrations of transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- in obese women .
17891595	0	TGF-beta1	48,57	transforming_growth_factor_beta1	14,46	TGF-beta1	transforming growth factor beta1	100008645(Tax:9986)	100008645(Tax:9986)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- on the regenerate bone in distraction osteogenesis .
20517890	0	TGF-beta1	47,56	transforming_growth_factor_beta_1	12,45	TGF-beta1	transforming growth factor beta 1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of transforming_growth_factor_beta_1 -LRB- TGF-beta1 -RRB- gene polymorphisms in Turkish patients with scleroderma .
12468040	0	TGF-beta1	0,9	tyrosine_hydroxylase	20,40	TGF-beta1	tyrosine hydroxylase	7040	7054	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	TGF-beta1 increases tyrosine_hydroxylase expression by a mechanism blocked by BMP-2 in human neuroblastoma SH-SY5Y cells .
19031438	0	TGF-beta2	38,47	Bone_morphogenetic_protein_4	0,28	TGF-beta2	Bone morphogenetic protein 4	7042	652	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Bone_morphogenetic_protein_4 inhibits TGF-beta2 stimulation of extracellular matrix proteins in optic nerve head cells : role of gremlin in ECM modulation .
19219652	0	TGF-beta2	14,23	MMP-2	27,32	TGF-beta2	MMP-2	7042	4313	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	The effect of TGF-beta2 on MMP-2 production and activity in highly metastatic human bladder_carcinoma cell line 5637 .
25728278	0	TGF-beta2	58,67	MiR-193b	0,8	TGF-beta2	MiR-193b	7042	574455	Gene	Gene	inhibiting|dobj|START_ENTITY regulates|advcl|inhibiting regulates|nsubj|END_ENTITY	MiR-193b regulates early chondrogenesis by inhibiting the TGF-beta2 signaling pathway .
12605052	0	TGF-beta2	42,51	Smad7	0,5	TGF-beta2	Smad7	100009371(Tax:9986)	100338818(Tax:9986)	Gene	Gene	effect|nmod|START_ENTITY suppresses|dobj|effect suppresses|nsubj|END_ENTITY	Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro .
17331500	0	TGF-beta2	60,69	VEGF	14,18	TGF-beta2	VEGF	7042	7422	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of VEGF mRNA expression and protein secretion by TGF-beta2 in human retinal pigment epithelial cells .
12107734	0	TGF-beta_1	29,39	Angiotensin_II	0,14	TGF-beta 1	Angiotensin II	7040	183	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Angiotensin_II induces human TGF-beta_1 promoter activation : similarity to hyperglycaemia .
8061046	0	TGF-beta_1	23,33	Angiotensin_II	0,14	TGF-beta 1	Angiotensin II	59086(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Angiotensin_II induces TGF-beta_1 production in rat heart endothelial cells .
9893729	0	TGF-beta_1	79,89	Angiotensin_II	0,14	TGF-beta 1	Angiotensin II	59086(Tax:10116)	24179(Tax:10116)	Gene	Gene	release|acl|START_ENTITY hypertrophy|nmod|release stimulates|dobj|hypertrophy stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta_1 and endothelin-1 from fibroblasts .
14707053	0	TGF-beta_1	0,10	CD25	59,63	TGF-beta 1	CD25	7040	3559	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|mechanism mechanism|nmod|activity activity|compound|END_ENTITY	TGF-beta_1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice .
17911604	0	TGF-beta_1	85,95	CD25	59,63	TGF-beta 1	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|compound|START_ENTITY adaptive|nsubj|+ induces|parataxis|adaptive induces|dobj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
14707053	0	TGF-beta_1	0,10	CD4	55,58	TGF-beta 1	CD4	7040	920	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|mechanism mechanism|nmod|activity activity|compound|END_ENTITY	TGF-beta_1 plays an important role in the mechanism of CD4 + CD25 + regulatory T cell activity in both humans and mice .
15048715	0	TGF-beta_1	43,53	CD4	0,3	TGF-beta 1	CD4	59086(Tax:10116)	24932(Tax:10116)	Gene	Gene	T|parataxis|START_ENTITY T|compound|END_ENTITY	CD4 + effector T cell distribution in vivo : TGF-beta_1 / TGF-beta receptor II interaction during activation mediates accumulation in the target tissue by preferential proliferation .
15699137	0	TGF-beta_1	20,30	CD4	34,37	TGF-beta 1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Distinct effects of TGF-beta_1 on CD4 + and CD8 + T cell survival , division , and IL-2 production : a role for T cell intrinsic Smad3 .
15879087	0	TGF-beta_1	0,10	CD4	71,74	TGF-beta 1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	uses|nsubj|START_ENTITY uses|xcomp|inhibit inhibit|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	TGF-beta_1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4 + T cells at priming and at recall : differential involvement of Stat4 and T-bet .
17579023	0	TGF-beta_1	0,10	CD4	38,41	TGF-beta 1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	TGF-beta_1 regulates antigen-specific CD4 + T cell responses in the periphery .
17911604	0	TGF-beta_1	85,95	CD4	55,58	TGF-beta 1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY adaptive|nsubj|+ induces|parataxis|adaptive induces|dobj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
19109141	0	TGF-beta_1	115,125	CD4	6,9	TGF-beta 1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	proliferation|nmod|START_ENTITY CD25|appos|proliferation CD25|compound|END_ENTITY	CD69 + CD4 + CD25 - T cells , a new subset of regulatory T cells , suppress T cell proliferation through membrane-bound TGF-beta_1 .
22049790	0	TGF-beta_1	52,62	CD4	16,19	TGF-beta 1	CD4	7040	920	Gene	Gene	CD25|amod|START_ENTITY CD25|compound|END_ENTITY	-LSB- Expressions of CD4 + CD25 -LRB- high -RRB- regulatory T cells , TGF-beta_1 and COX-2 in the peripheral blood of prostate_cancer patients -RSB- .
8642767	0	TGF-beta_1	62,72	CD4	181,184	TGF-beta 1	CD4	7040	920	Gene	Gene	level|appos|START_ENTITY level|appos|CD3 CD3|dep|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
19109141	0	TGF-beta_1	115,125	CD69	0,4	TGF-beta 1	CD69	21803(Tax:10090)	12515(Tax:10090)	Gene	Gene	proliferation|nmod|START_ENTITY CD25|appos|proliferation CD25|compound|END_ENTITY	CD69 + CD4 + CD25 - T cells , a new subset of regulatory T cells , suppress T cell proliferation through membrane-bound TGF-beta_1 .
8642767	0	TGF-beta_1	62,72	CD8	186,189	TGF-beta 1	CD8	7040	925	Gene	Gene	level|appos|START_ENTITY level|appos|CD3 CD3|dep|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
15361357	0	TGF-beta_1	0,10	CFTR	25,29	TGF-beta 1	CFTR	7040	1080	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	TGF-beta_1 downregulates CFTR expression and function in nasal_polyps of non-CF patients .
8655583	0	TGF-beta_1	41,51	Endoglin	0,8	TGF-beta 1	Endoglin	7040	2022	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Endoglin modulates cellular responses to TGF-beta_1 .
15879091	0	TGF-beta_1	0,10	Fc_epsilon_RI	30,43	TGF-beta 1	Fc epsilon RI	7040	2205	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	TGF-beta_1 inhibits mast cell Fc_epsilon_RI expression .
17911604	0	TGF-beta_1	85,95	Foxp3	64,69	TGF-beta 1	Foxp3	21803(Tax:10090)	20371(Tax:10090)	Gene	Gene	+|compound|START_ENTITY adaptive|nsubj|+ induces|parataxis|adaptive induces|dobj|+ +|compound|END_ENTITY	Enhanced engagement of CTLA-4 induces antigen-specific CD4 + CD25 + Foxp3 + and CD4 + CD25 - TGF-beta_1 + adaptive regulatory T cells .
12421979	0	TGF-beta_1	64,74	IFN-gamma	17,26	TGF-beta 1	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY pathways|nmod|absence pathways|nsubj|Dysregulation Dysregulation|nmod|signaling signaling|compound|END_ENTITY	Dysregulation of IFN-gamma signaling pathways in the absence of TGF-beta_1 .
12563723	0	TGF-beta_1	51,61	IFN-gamma	12,21	TGF-beta 1	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	hepatocytes|nmod|START_ENTITY hepatocytes|amod|END_ENTITY	-LSB- Effects of IFN-gamma gene-modified hepatocytes on TGF-beta_1 and its receptor in mice infected with Schistosoma_japonicum -RSB- .
12740179	0	TGF-beta_1	48,58	IFN-gamma	21,30	TGF-beta 1	IFN-gamma	574135(Tax:9544)	574282(Tax:9544)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Regulatory effect of IFN-gamma on expression of TGF-beta_1 , T beta R-II , and StAR in corpus luteum of pregnant rhesus_monkey .
15879087	0	TGF-beta_1	0,10	IFN-gamma	47,56	TGF-beta 1	IFN-gamma	21803(Tax:10090)	15978(Tax:10090)	Gene	Gene	uses|nsubj|START_ENTITY uses|xcomp|inhibit inhibit|dobj|expression expression|amod|END_ENTITY	TGF-beta_1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4 + T cells at priming and at recall : differential involvement of Stat4 and T-bet .
21591983	0	TGF-beta_1	28,38	IFN-gamma	53,62	TGF-beta 1	IFN-gamma	7040	3458	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
9682131	0	TGF-beta_1	52,62	IGF-1	96,101	TGF-beta 1	IGF-1	282089(Tax:9913)	281239(Tax:9913)	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- and insulin-like_growth_factor -LRB- IGF-1 -RRB- in bovine colostrum samples .
12837295	0	TGF-beta_1	0,10	IGF-I	25,30	TGF-beta 1	IGF-I	59086(Tax:10116)	24482(Tax:10116)	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	TGF-beta_1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells .
21591983	0	TGF-beta_1	28,38	IL-10	40,45	TGF-beta 1	IL-10	7040	3586	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
10936508	0	TGF-beta_1	0,10	IL-2	36,40	TGF-beta 1	IL-2	7040	3558	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TGF-beta_1 differentially regulates IL-2 expression and -LSB- 3H -RSB- - thymidine incorporation in CD3 epsilon mAb - and CD28 mAb-activated splenocytes and thymocytes .
15034041	0	TGF-beta_1	23,33	IL-2	46,50	TGF-beta 1	IL-2	21803(Tax:10090)	16183(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|xcomp|suppress suppress|dobj|production production|compound|END_ENTITY	Smad3 is essential for TGF-beta_1 to suppress IL-2 production and TCR-induced proliferation , but not IL-2-induced proliferation .
7948746	0	TGF-beta_1	35,45	IL-2	112,116	TGF-beta 1	IL-2	7040	3558	Gene	Gene	Transforming_growth_factor-beta_1|appos|START_ENTITY inhibits|nsubj|Transforming_growth_factor-beta_1 inhibits|dobj|synthesis synthesis|nmod|PBMC PBMC|nmod|suppression suppression|nmod|production production|amod|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- inhibits DNA synthesis of PWM-stimulated PBMC via suppression of IL-2 and IL-6 production .
8811326	0	TGF-beta_1	69,79	IL-2	103,107	TGF-beta 1	IL-2	7040	3558	Gene	Gene	transforming_growth_factor-beta_1|appos|START_ENTITY stimulate|dobj|transforming_growth_factor-beta_1 stimulate|dobj|production production|compound|END_ENTITY	Elevated glucose levels stimulate transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- , suppress interleukin IL-2 , IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells .
10925306	0	TGF-beta_1	47,57	IL-6	174,178	TGF-beta 1	IL-6	7040	3569	Gene	Gene	transduction|compound|START_ENTITY generation|nmod|transduction Requirement|nmod|generation Requirement|dep|involvement involvement|nmod|expression expression|compound|END_ENTITY	Requirement of hydrogen_peroxide generation in TGF-beta_1 signal transduction in human lung fibroblast cells : involvement of hydrogen_peroxide and Ca2 + in TGF-beta_1-induced IL-6 expression .
14734728	0	TGF-beta_1	74,84	IL-6	43,47	TGF-beta 1	IL-6	7040	3569	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|secretion secretion|nmod|END_ENTITY	Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta_1 and restores the lymphokine-activated killing activity .
21591983	0	TGF-beta_1	28,38	IL-6	47,51	TGF-beta 1	IL-6	7040	3569	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
8742067	0	TGF-beta_1	0,10	IL-6	86,90	TGF-beta 1	IL-6	7040	3569	Gene	Gene	differentially|compound|START_ENTITY modulate|nsubj|differentially modulate|dobj|expression expression|nmod|END_ENTITY	TGF-beta_1 , IL-10 and IL-4 differentially modulate the cytokine-induced expression of IL-6 and IL-8 in human endothelial cells .
21591983	0	TGF-beta_1	28,38	MBL	64,67	TGF-beta 1	MBL	7040	50639	Gene	Gene	GPIA|appos|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
17374997	0	TGF-beta_1	54,64	PKN	0,3	TGF-beta 1	PKN	7040	5585	Gene	Gene	receptor|compound|START_ENTITY activation|nmod|receptor activation|compound|END_ENTITY	PKN activation via transforming growth factor-beta 1 -LRB- TGF-beta_1 -RRB- receptor signaling delays G2/M phase transition in vascular smooth muscle cells .
14636827	0	TGF-beta_1	47,57	Smad3	99,104	TGF-beta 1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Concentration-dependent bifunctional effect of TGF-beta_1 on immunoglobulin production : a role for Smad3 in IgA production in vitro .
15034041	0	TGF-beta_1	23,33	Smad3	0,5	TGF-beta 1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Smad3 is essential for TGF-beta_1 to suppress IL-2 production and TCR-induced proliferation , but not IL-2-induced proliferation .
12479057	0	TGF-beta_1	29,39	Smad7	15,20	TGF-beta 1	Smad7	7040	4092	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|amod|END_ENTITY	-LSB- Regulation of Smad7 gene by TGF-beta_1 in process of malignant transformation -RSB- .
11713352	0	TGF-beta_1	29,39	TGF-beta_1	64,74	TGF-beta 1	TGF-beta 1	7040	7040	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Regulation of the effects of TGF-beta_1 by activation of latent TGF-beta_1 and differential expression of TGF-beta_receptors _ -LRB- T_beta_R-I_and_T_beta_R-II -RRB- in idiopathic_pulmonary_fibrosis .
11713352	0	TGF-beta_1	64,74	TGF-beta_1	29,39	TGF-beta 1	TGF-beta 1	7040	7040	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Regulation of the effects of TGF-beta_1 by activation of latent TGF-beta_1 and differential expression of TGF-beta_receptors _ -LRB- T_beta_R-I_and_T_beta_R-II -RRB- in idiopathic_pulmonary_fibrosis .
12697700	0	TGF-beta_1	116,126	TGF-beta_1	46,56	TGF-beta 1	TGF-beta 1	359834(Tax:7955)	359834(Tax:7955)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- and its type II receptor from zebrafish ovary and role of TGF-beta_1 in oocyte maturation .
12697700	0	TGF-beta_1	46,56	TGF-beta_1	116,126	TGF-beta 1	TGF-beta 1	359834(Tax:7955)	359834(Tax:7955)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- and its type II receptor from zebrafish ovary and role of TGF-beta_1 in oocyte maturation .
1658013	0	TGF-beta_1	50,60	TGF-beta_1	75,85	TGF-beta 1	TGF-beta 1	7040	7040	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Platelet factor 4 selectively inhibits binding of TGF-beta_1 to the type I TGF-beta_1 receptor .
1658013	0	TGF-beta_1	75,85	TGF-beta_1	50,60	TGF-beta 1	TGF-beta 1	7040	7040	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Platelet factor 4 selectively inhibits binding of TGF-beta_1 to the type I TGF-beta_1 receptor .
7669547	0	TGF-beta_1	34,44	TGF-beta_3	14,24	TGF-beta 1	TGF-beta 3	21803(Tax:10090)	21809(Tax:10090)	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Inhibition of TGF-beta_3 -LRB- but not TGF-beta_1 or TGF-beta_2 -RRB- activity prevents normal mouse embryonic_palate fusion .
11046022	0	TGF-beta_1	0,10	TNF-alpha	57,66	TGF-beta 1	TNF-alpha	21803(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	TGF-beta_1 and IFN-gamma direct macrophage activation by TNF-alpha to osteoclastic or cytocidal phenotype .
21591983	0	TGF-beta_1	28,38	TNF-alpha	17,26	TGF-beta 1	TNF-alpha	7040	7124	Gene	Gene	GPIA|appos|START_ENTITY GPIA|compound|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
12767908	0	TGF-beta_1	80,90	TSC-22	34,40	TGF-beta 1	TSC-22	7040	8848	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Posttranscriptional regulation of TSC-22 -LRB- TGF-beta-stimulated_clone-22 -RRB- gene by TGF-beta_1 .
14871177	0	TGF-beta_1	35,45	Transforming_growth_factor-beta_1	0,33	TGF-beta 1	Transforming growth factor-beta 1	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression in normal healthy pulps and in those with irreversible pulpitis .
1732279	0	TGF-beta_1	35,45	Transforming_growth_factor-beta_1	0,33	TGF-beta 1	Transforming growth factor-beta 1	59086(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression and regulation in rat cortical astrocytes .
21541485	0	TGF-beta_1	35,45	Transforming_growth_factor_beta_1	0,33	TGF-beta 1	Transforming growth factor beta 1	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- expression in proliferating thyroid_disease .
7720396	0	TGF-beta_1	0,10	alpha-smooth_muscle_actin	44,69	TGF-beta 1	alpha-smooth muscle actin	59086(Tax:10116)	25365(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	TGF-beta_1 induces lens cells to accumulate alpha-smooth_muscle_actin , a marker for subcapsular cataracts .
10331853	0	TGF-beta_1	0,10	angiotensin_II	56,70	TGF-beta 1	angiotensin II	59086(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|dep|role role|nmod|END_ENTITY	TGF-beta_1 production in radiation nephropathy : role of angiotensin_II .
1850693	0	TGF-beta_1	0,10	cyclic_AMP_responsive_element_binding_protein	42,87	TGF-beta 1	cyclic AMP responsive element binding protein	7040	1385	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	TGF-beta_1 induces phosphorylation of the cyclic_AMP_responsive_element_binding_protein in ML-CCl64 cells .
9551912	0	TGF-beta_1	0,10	p27Kip1	57,64	TGF-beta 1	p27Kip1	21803(Tax:10090)	12576(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|amod|END_ENTITY	TGF-beta_1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells .
11046029	0	TGF-beta_1	83,93	p38	104,107	TGF-beta 1	p38	7040	1432	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Potent induction of alpha -LRB- 1,3 -RRB- - fucosyltransferase VII in activated CD4 + T cells by TGF-beta_1 through a p38 mitogen-activated protein kinase-dependent pathway .
7555731	0	TGF-beta_1	55,65	pRb	0,3	TGF-beta 1	pRb	21803(Tax:10090)	19645(Tax:10090)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	pRb is necessary for inhibition of N-myc expression by TGF-beta_1 in embryonic lung organ cultures .
1851752	0	TGF-beta_1	62,72	transforming_growth_factor-beta_1	27,60	TGF-beta 1	transforming growth factor-beta 1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Differential expression of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- receptors in murine myeloid cell lines transformed with oncogenes .
7729516	0	TGF-beta_1	11,21	transforming_growth_factor-beta_1	23,56	TGF-beta 1	transforming growth factor-beta 1	7040	7040	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of TGF-beta_1 -LRB- transforming_growth_factor-beta_1 -RRB- on the cell cycle regulation of human breast_adenocarcinoma -LRB- MCF-7 -RRB- cells .
7980578	0	TGF-beta_1	49,59	transforming_growth_factor-beta_1	14,47	TGF-beta 1	transforming growth factor-beta 1	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression with a novel TGF-beta_1 complementary DNA .
7980578	0	TGF-beta_1	85,95	transforming_growth_factor-beta_1	14,47	TGF-beta 1	transforming growth factor-beta 1	7040	7040	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression with a novel TGF-beta_1 complementary DNA .
8050182	0	TGF-beta_1	65,75	transforming_growth_factor-beta_1	30,63	TGF-beta 1	transforming growth factor-beta 1	7040	7040	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Intraglomerular expression of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- mRNA in patients with glomerulonephritis : quantitative analysis by competitive polymerase chain reaction .
8086280	0	TGF-beta_1	119,129	transforming_growth_factor-beta_1	84,117	TGF-beta 1	transforming growth factor-beta 1	100008645(Tax:9986)	100008645(Tax:9986)	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Different phosphorylated forms of inositolphosphate_glycan could be involved in the transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- signalling pathway .
7895806	0	TGF-beta_1	81,91	transforming_growth_factor_beta-1	46,79	TGF-beta 1	transforming growth factor beta-1	59086(Tax:10116)	59086(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Cytokines in cerebral_ischemia : expression of transforming_growth_factor_beta-1 -LRB- TGF-beta_1 -RRB- mRNA in the postischemic adult rat hippocampus .
1525582	0	TGF-beta_1	50,60	transforming_growth_factor_beta_1	15,48	TGF-beta 1	transforming growth factor beta 1	443417(Tax:9940)	443417(Tax:9940)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Iodide induces transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- mRNA in sheep thyroid cells .
2358774	0	TGF-beta_1	58,68	transforming_growth_factor_beta_1	23,56	TGF-beta 1	transforming growth factor beta 1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transactivation of the transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- gene by human_T_lymphotropic_virus_type_1 tax : a potential mechanism for the increased production of TGF-beta_1 in adult_T_cell_leukemia .
9169066	0	TGF-beta_1	65,75	transforming_growth_factor_beta_1	30,63	TGF-beta 1	transforming growth factor beta 1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of liver-associated transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- mRNA expression by carbon_tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines .
7561083	0	TGF-beta_2	20,30	CD4	68,71	TGF-beta 2	CD4	21808(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|development development|nmod|T T|compound|END_ENTITY	Opposing effects of TGF-beta_2 on the Th1 cell development of naive CD4 + T cells isolated from different mouse strains .
8819159	0	TGF-beta_2	54,64	TGF-beta_3	25,35	TGF-beta 2	TGF-beta 3	7042	7043	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of TGF-beta_3 and comparison to TGF-beta_2 : implications for receptor binding .
1280203	0	TGF-beta_2	74,84	transforming_growth_factor-beta_2	39,72	TGF-beta 2	transforming growth factor-beta 2	81809(Tax:10116)	81809(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Porcine granulosa cells do not express transforming_growth_factor-beta_2 -LRB- TGF-beta_2 -RRB- messenger ribonucleic_acid : molecular basis for their inability to produce TGF-beta activity comparable to that of rat granulosa cells .
8471538	0	TGF-beta_3	65,75	Growth_factor	0,13	TGF-beta 3	Growth factor	25717(Tax:10116)	79215(Tax:10116)	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|amod|END_ENTITY	Growth_factor expression during rat development : a comparison of TGF-beta_3 , TGF-alpha , bFGF , PDGF and PDGF-R .
8133057	0	TGF-beta_3	80,90	TGF-beta	37,45	TGF-beta 3	TGF-beta	7043	7040	Gene	Gene	chemotaxis|appos|START_ENTITY chemotaxis|nmod|response response|nmod|isoforms isoforms|amod|END_ENTITY	Neutrophil chemotaxis in response to TGF-beta isoforms -LRB- TGF-beta_1 , TGF-beta_2 , TGF-beta_3 -RRB- is mediated by fibronectin .
8562514	0	TGF-beta_3	38,48	TGF-beta	61,69	TGF-beta 3	TGF-beta	7043	7040	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Human thymic epithelial cells produce TGF-beta_3 and express TGF-beta receptors .
7669547	0	TGF-beta_3	14,24	TGF-beta_1	34,44	TGF-beta 3	TGF-beta 1	21809(Tax:10090)	21803(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Inhibition of TGF-beta_3 -LRB- but not TGF-beta_1 or TGF-beta_2 -RRB- activity prevents normal mouse embryonic_palate fusion .
8819159	0	TGF-beta_3	25,35	TGF-beta_2	54,64	TGF-beta 3	TGF-beta 2	7043	7042	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The crystal structure of TGF-beta_3 and comparison to TGF-beta_2 : implications for receptor binding .
9524286	0	TGF-beta_5	100,110	transforming_growth_factor-beta_5	65,98	TGF-beta 5	transforming growth factor-beta 5	397778(Tax:8355)	397778(Tax:8355)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Characterization of the 5 ' flanking region of the Xenopus_laevis transforming_growth_factor-beta_5 -LRB- TGF-beta_5 -RRB- gene .
10226558	0	TGF-beta_RII	58,70	transforming_growth_factor-beta_type_II_receptor	8,56	TGF-beta RII	transforming growth factor-beta type II receptor	7048	7048	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Reduced transforming_growth_factor-beta_type_II_receptor -LRB- TGF-beta_RII -RRB- expression in adenocarcinoma_of_the_lung .
15532825	0	TGF-beta_receptor_type_II	82,107	TGF-beta1	49,58	TGF-beta receptor type II	TGF-beta1	7048	7040	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	Serum level of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- and the expression of TGF-beta_receptor_type_II in peripheral blood mononuclear cells in patients with autoimmune_hepatitis .
16267045	1	TGF-beta_receptors_I_and_II	178,205	PP1	156,159	TGF-beta receptors I and II	PP1	21813(Tax:10090)	19047(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	PP1 directly inhibits TGF-beta_receptors_I_and_II .
17440088	0	TGF-beta_type_II_receptor	29,54	Src	0,3	TGF-beta type II receptor	Src	7048	6714	Gene	Gene	phosphorylates|nmod|START_ENTITY phosphorylates|nsubj|END_ENTITY	Src phosphorylates Tyr284 in TGF-beta_type_II_receptor and regulates TGF-beta stimulation of p38 MAPK during breast_cancer cell proliferation and invasion .
16258068	0	TGF-beta_type_II_receptor	90,115	TGF-beta	51,59	TGF-beta type II receptor	TGF-beta	7048	7040	Gene	Gene	inactivating|dobj|START_ENTITY signaling|advcl|inactivating END_ENTITY|acl|signaling	The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta_type_II_receptor .
10664470	0	TGF-beta_type_I_receptor	32,56	ALK-5	63,68	TGF-beta type I receptor	ALK-5	29591(Tax:10116)	29591(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative splicing within the TGF-beta_type_I_receptor gene -LRB- ALK-5 -RRB- generates two major functional isoforms in vascular smooth muscle cells .
11408925	0	TGFB	22,26	TGFB	62,66	TGFB	TGFB	7040	7040	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|nmod|END_ENTITY	Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic_carcinomas .
11408925	0	TGFB	62,66	TGFB	22,26	TGFB	TGFB	7040	7040	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	Altered expression of TGFB receptors and mitogenic effects of TGFB in pancreatic_carcinomas .
25148573	0	TGFB1	66,71	MiR-663	0,7	TGFB1	MiR-663	7040	724033	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode .
25483041	0	TGFB1	66,71	MiR-663	0,7	TGFB1	MiR-663	7040	724033	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode .
23703862	0	TGFB1	52,57	TGFB1	82,87	TGFB1	TGFB1	7040	7040	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Genetic association and gene expression profiles of TGFB1 and the contribution of TGFB1 to otosclerosis susceptibility .
23703862	0	TGFB1	82,87	TGFB1	52,57	TGFB1	TGFB1	7040	7040	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Genetic association and gene expression profiles of TGFB1 and the contribution of TGFB1 to otosclerosis susceptibility .
15253388	0	TGFB1	45,50	TGFB4	31,36	TGFB1	TGFB4	100873157	100873157	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	On reassessment of the chicken TGFB4 gene as TGFB1 .
26850833	0	TGFB1	20,25	THBS1	0,5	TGFB1	THBS1	21803(Tax:10090)	21825(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral_squamous_cell_carcinoma .
26048435	0	TGFB1	59,64	transforming_growth_factor-b1	28,57	TGFB1	transforming growth factor-b1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	c. 29C > T polymorphism in the transforming_growth_factor-b1 -LRB- TGFB1 -RRB- gene correlates with increased risk of urinary bladder_cancer .
11311337	0	TGFB1	60,65	transforming_growth_factor-beta1	26,58	TGFB1	transforming growth factor-beta1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence variation in the transforming_growth_factor-beta1 -LRB- TGFB1 -RRB- gene and multiple_sclerosis susceptibility .
12938093	0	TGFB1	71,76	transforming_growth_factor-beta_1	36,69	TGFB1	transforming growth factor-beta 1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of novel variants in transforming_growth_factor-beta_1 -LRB- TGFB1 -RRB- gene and association analysis with bone mineral density .
18284942	0	TGFB1	105,110	transforming_growth_factor_beta_1	65,98	TGFB1	transforming growth factor beta 1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Large-scale analysis of association between polymorphisms in the transforming_growth_factor_beta_1 gene -LRB- TGFB1 -RRB- and osteoporosis : the GENOMOS study .
8095486	0	TGFB2	24,29	HLX1	58,62	TGFB2	HLX1	7042	3142	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q .
26612435	0	TGFB3	7,12	TGFb3	0,5	TGFB3	TGFb3	7043	7043	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	TGFb3 -LRB- TGFB3 -RRB- polymorphism is associated with male_infertility .
15253388	0	TGFB4	31,36	TGFB1	45,50	TGFB4	TGFB1	100873157	100873157	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	On reassessment of the chicken TGFB4 gene as TGFB1 .
10328397	0	TGFBI	33,38	BIGH3	40,45	TGFBI	BIGH3	7045	7045	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A mutation within exon 14 of the TGFBI -LRB- BIGH3 -RRB- gene on chromosome 5q31 causes an asymmetric , late-onset form of lattice corneal_dystrophy .
12770961	0	TGFBI	33,38	BIGH3	40,45	TGFBI	BIGH3	7045	7045	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	H626R and R124C mutations of the TGFBI -LRB- BIGH3 -RRB- gene caused lattice_corneal_dystrophy in Vietnamese people .
14597039	0	TGFBI	49,54	BIGH3	56,61	TGFBI	BIGH3	7045	7045	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new mutation -LRB- Leu569Arg -RRB- within exon 13 of the TGFBI -LRB- BIGH3 -RRB- gene causes lattice corneal_dystrophy type I. PURPOSE : To describe an American family with lattice corneal_dystrophy type I , which associates with a novel mutation , Leu569Arg , of the TGFBI -LRB- BIGH3 -RRB- gene .
15111592	0	TGFBI	21,26	BIGH3	28,33	TGFBI	BIGH3	7045	7045	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Two mutations in the TGFBI -LRB- BIGH3 -RRB- gene associated with lattice_corneal_dystrophy in an extensively studied family .
18470323	0	TGFBI	85,90	BIGH3	92,97	TGFBI	BIGH3	7045	7045	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Anticipation in familial lattice corneal_dystrophy type I with R124C mutation in the TGFBI -LRB- BIGH3 -RRB- gene .
24589966	0	TGFBI	116,121	BIGH3	123,128	TGFBI	BIGH3	7045	7045	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lattice Corneal_Dystrophy : a report of two cases in twin sisters due to 3 mutations -LRB- T1620C , C1416T , A1924G -RRB- in the TGFBI -LRB- BIGH3 -RRB- gene .
11095060	0	TGFBI	27,32	betaig-h3	34,43	TGFBI	betaig-h3	7045	7045	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Six different mutations of TGFBI -LRB- betaig-h3 , keratoepithelin -RRB- gene found in Japanese corneal_dystrophies .
18245446	0	TGFBI	39,44	betaig-h3	29,38	TGFBI	betaig-h3	7045	7045	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Extracellular matrix protein betaig-h3 / TGFBI promotes metastasis of colon_cancer by enhancing cell extravasation .
25889002	0	TGFBI	12,17	big-H3	19,25	TGFBI	big-H3	21810(Tax:10090)	21810(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of TGFBI -LRB- big-H3 -RRB- in gastrointestinal tract tumorigenesis .
25889002	0	TGFBI	12,17	big-H3	19,25	TGFBI	big-H3	21810(Tax:10090)	21810(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of TGFBI -LRB- big-H3 -RRB- in gastrointestinal tract tumorigenesis .
15885785	0	TGFBI	143,148	transforming_growth_factor_beta-induced	102,141	TGFBI	transforming growth factor beta-induced	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A unique corneal_dystrophy of Bowman 's layer and stroma associated with the Gly623Asp mutation in the transforming_growth_factor_beta-induced -LRB- TGFBI -RRB- gene .
24302499	0	TGFBI	138,143	transforming_growth_factor_beta_induced	97,136	TGFBI	transforming growth factor beta induced	7045	7045	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparison of two phenotypically distinct lattice corneal_dystrophies caused by mutations in the transforming_growth_factor_beta_induced -LRB- TGFBI -RRB- gene .
26915797	0	TGFBIp	16,22	TGF-b	0,5	TGFBIp	TGF-b	7045	7040	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGF-b regulates TGFBIp expression in corneal fibroblasts via miR-21 , miR-181a , and Smad signaling .
25910219	0	TGFBIp	64,70	Transforming_Growth_Factor_Beta-Induced	15,54	TGFBIp	Transforming Growth Factor Beta-Induced	7045	7045	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	Fibril Core of Transforming_Growth_Factor_Beta-Induced Protein -LRB- TGFBIp -RRB- Facilitates Aggregation of Corneal TGFBIp .
11329144	0	TGFBR1	24,30	TSC1	32,36	TGFBR1	TSC1	7046	7248	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The chromosome 9q genes TGFBR1 , TSC1 , and ZNF189 are rarely mutated in bladder_cancer .
16341765	0	TGFBR1	83,89	transforming_growth_factor_beta_receptor_1	39,81	TGFBR1	transforming growth factor beta receptor 1	396665(Tax:9823)	396665(Tax:9823)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Structure and polymorphism analysis of transforming_growth_factor_beta_receptor_1 -LRB- TGFBR1 -RRB- in pigs .
16950575	0	TGFBR1	105,111	transforming_growth_factor_beta_type_I_receptor	56,103	TGFBR1	transforming growth factor beta type I receptor	396665(Tax:9823)	396665(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation and molecular characterization of the porcine transforming_growth_factor_beta_type_I_receptor -LRB- TGFBR1 -RRB- gene .
22292700	0	TGFBR1	76,82	transforming_growth_factor_beta_type_I_receptor	27,74	TGFBR1	transforming growth factor beta type I receptor	396665(Tax:9823)	396665(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of the porcine transforming_growth_factor_beta_type_I_receptor -LRB- TGFBR1 -RRB- gene with growth and carcass traits .
25890570	0	TGFBR2	102,108	Androgen_Receptor	4,21	TGFBR2	Androgen Receptor	7048	367	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Re : Androgen_Receptor and MicroRNA-21 Axis Downregulates Transforming_Growth_Factor_Beta_Receptor_II -LRB- TGFBR2 -RRB- Expression in Prostate_Cancer .
25551793	0	TGFBR2	59,65	MicroRNA-301a	0,13	TGFBR2	MicroRNA-301a	7048	407027	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal_cancer .
25890570	0	TGFBR2	102,108	Transforming_Growth_Factor_Beta_Receptor_II	57,100	TGFBR2	Transforming Growth Factor Beta Receptor II	7048	7048	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Re : Androgen_Receptor and MicroRNA-21 Axis Downregulates Transforming_Growth_Factor_Beta_Receptor_II -LRB- TGFBR2 -RRB- Expression in Prostate_Cancer .
25323858	0	TGFBR2	26,32	miR145	9,15	TGFBR2	miR145	21813(Tax:10090)	387163(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	MicroRNA miR145 Regulates TGFBR2 Expression and Matrix Synthesis in Vascular Smooth Muscle Cells .
26177744	0	TGFBR2	132,138	nectin-3	120,128	TGFBR2	nectin-3	7048	25945	Gene	Gene	target|compound|START_ENTITY END_ENTITY|nmod|target	A new method for detection of tumor driver-dependent changes of protein sialylation in a colon_cancer cell line reveals nectin-3 as TGFBR2 target .
24037531	0	TGFBR2	98,104	transforming_growth_factor_beta_receptor_II	53,96	TGFBR2	transforming growth factor beta receptor II	7048	7048	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Androgen_receptor and microRNA-21 axis downregulates transforming_growth_factor_beta_receptor_II -LRB- TGFBR2 -RRB- expression in prostate_cancer .
17566598	0	TGFBR2	74,80	transforming_growth_factor_beta_type_II_receptor	24,72	TGFBR2	transforming growth factor beta type II receptor	7048	7048	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Defective expression of transforming_growth_factor_beta_type_II_receptor -LRB- TGFBR2 -RRB- in the large cell variant of non-small_cell_lung_carcinoma .
18236212	0	TGFBR3	27,33	betaglycan	35,45	TGFBR3	betaglycan	21814(Tax:10090)	21814(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of TGFBR3 -LRB- betaglycan -RRB- in mouse ovary and testis during gonadogenesis .
1928747	0	TGF_alpha	104,113	EGF	47,50	TGF alpha	EGF	21802(Tax:10090)	13645(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY Immunolocalization|nmod|receptor Immunolocalization|appos|END_ENTITY	Immunolocalization of epidermal_growth_factor -LRB- EGF -RRB- , EGF receptor and transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- during murine palatogenesis in vivo and in vitro .
1928747	0	TGF_alpha	104,113	EGF	53,56	TGF alpha	EGF	21802(Tax:10090)	13645(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Immunolocalization of epidermal_growth_factor -LRB- EGF -RRB- , EGF receptor and transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- during murine palatogenesis in vivo and in vitro .
7829602	0	TGF_alpha	110,119	EGF	70,73	TGF alpha	EGF	7039	1950	Gene	Gene	transforming_growth_factor-alpha|appos|START_ENTITY acid|appos|transforming_growth_factor-alpha acid|appos|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
7829602	0	TGF_alpha	179,188	EGF	70,73	TGF alpha	EGF	7039	1950	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|acid acid|appos|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
9787404	0	TGF_alpha	63,72	EGF	58,61	TGF alpha	EGF	7039	1950	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
9787404	0	TGF_alpha	63,72	TGF_beta_1	74,84	TGF alpha	TGF beta 1	7039	7040	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
8404616	0	TGF_alpha	34,43	Transforming_growth_factor-alpha	0,32	TGF alpha	Transforming growth factor-alpha	24827(Tax:10116)	24827(Tax:10116)	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- concentrations increase in regenerating rat liver : evidence for a delayed accumulation of mature TGF_alpha .
8426908	0	TGF_alpha	34,43	Transforming_growth_factor-alpha	0,32	TGF alpha	Transforming growth factor-alpha	7039	7124	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- inhibition of parietal cell secretion : structural requirements for activity .
8027772	0	TGF_alpha	34,43	Transforming_growth_factor_alpha	0,32	TGF alpha	Transforming growth factor alpha	21802(Tax:10090)	21802(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- expression in degenerating motoneurons of the murine mutant wobbler : a neuronal signal for astrogliosis ?
8432738	0	TGF_alpha	98,107	aminopeptidase	68,82	TGF alpha	aminopeptidase	7039	10404	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Low fluences of ultraviolet irradiation stimulate HeLa cell surface aminopeptidase and candidate `` TGF_alpha ase '' activity .
8458346	0	TGF_alpha	42,51	c-erbB	62,68	TGF alpha	c-erbB	414743(Tax:9031)	396494(Tax:9031)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The estrogen receptor cooperates with the TGF_alpha receptor -LRB- c-erbB -RRB- in regulation of chicken erythroid progenitor self-renewal .
9787404	0	TGF_alpha	63,72	glucocorticoid_receptor	19,42	TGF alpha	glucocorticoid receptor	7039	2908	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
7770629	0	TGF_alpha	95,104	ornithine_decarboxylase	55,78	TGF alpha	ornithine decarboxylase	24827(Tax:10116)	24609(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acid secretory response and induction of ornithine_decarboxylase and its mRNA by TGF_alpha and EGF in isolated rat gastric glands .
7829602	0	TGF_alpha	179,188	transforming_growth_factor-alpha	76,108	TGF alpha	transforming growth factor-alpha	7039	7124	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|acid acid|appos|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
8137635	0	TGF_alpha	48,57	transforming_growth_factor-alpha	14,46	TGF alpha	transforming growth factor-alpha	100009482(Tax:9986)	100009150(Tax:9986)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- on rabbit and primate lens epithelial cells in vitro .
8326464	0	TGF_alpha	63,72	transforming_growth_factor-alpha	29,61	TGF alpha	transforming growth factor-alpha	24827(Tax:10116)	24827(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Intrahepatic distribution of transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- during liver_regeneration following carbon_tetrachloride-induced necrosis .
1524218	0	TGF_alpha	110,119	transforming_growth_factor_alpha	76,108	TGF alpha	transforming growth factor alpha	7039	7124	Gene	Gene	modulators|appos|START_ENTITY modulators|nmod|END_ENTITY	Characterization of a scintillation proximity assay to detect modulators of transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- binding .
2043488	0	TGF_alpha	48,57	transforming_growth_factor_alpha	14,46	TGF alpha	transforming growth factor alpha	7039	7124	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- in breast_cancer .
2324504	0	TGF_alpha	95,104	transforming_growth_factor_alpha	61,93	TGF alpha	transforming growth factor alpha	7039	7124	Gene	Gene	assay|appos|START_ENTITY assay|nmod|END_ENTITY	A new sandwich enzyme-linked immunosorbent assay -LRB- ELISA -RRB- for transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- based upon conformational modification by antibody binding .
7702037	0	TGF_alpha	55,64	transforming_growth_factor_alpha	21,53	TGF alpha	transforming growth factor alpha	7039	7124	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Association study of transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- TaqI polymorphism and oral clefts : indication of gene-environment interaction in a population-based sample of infants with birth_defects .
8360257	0	TGF_alpha	106,115	transforming_growth_factor_alpha	14,46	TGF alpha	transforming growth factor alpha	7039	7124	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|Expression Expression|nmod|mRNA mRNA|compound|END_ENTITY	Expression of transforming_growth_factor_alpha antisense mRNA inhibits the estrogen-induced production of TGF_alpha and estrogen-induced proliferation of estrogen-responsive human breast_cancer cells .
12539376	0	TGF_beta	12,20	BMP-2	24,29	TGF beta	BMP-2	7040	650	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|cells cells|compound|END_ENTITY	-LSB- Effects of TGF_beta on BMP-2 gene transfection cells in vitro -RSB- .
8552986	0	TGF_beta	137,145	GM-CSF	165,171	TGF beta	GM-CSF	7040	1437	Gene	Gene	G-CSF|appos|START_ENTITY erythrocytes|dep|G-CSF Adhesion|nmod|erythrocytes END_ENTITY|nsubj|Adhesion	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	TGF_beta	137,145	IL-1-beta	99,108	TGF beta	IL-1-beta	7040	3553	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|compound|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	TGF_beta	137,145	IL-10	130,135	TGF beta	IL-10	7040	3586	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	TGF_beta	137,145	IL-1RA	110,116	TGF beta	IL-1RA	7040	3557	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	TGF_beta	137,145	IL-6	118,122	TGF beta	IL-6	7040	3569	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	TGF_beta	137,145	IL-8	124,128	TGF beta	IL-8	7040	3576	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
11418694	0	TGF_beta	105,113	STAT3	72,77	TGF beta	STAT3	7040	6774	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF_beta is reversed by IL-15 .
2541074	0	TGF_beta	0,8	TLiSA1	24,30	TGF beta	TLiSA1	7040	10666	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	TGF_beta down-regulates TLiSA1 expression and inhibits the differentiation of precursor lymphocytes into CTL and LAK cells .
8552986	0	TGF_beta	137,145	TNF_alpha	147,156	TGF beta	TNF alpha	7040	7124	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8634677	0	TGF_beta	33,41	Transforming_growth_factor_beta	0,31	TGF beta	Transforming growth factor beta	7040	7040	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Transforming_growth_factor_beta -LRB- TGF_beta -RRB- activity in urine of patients with glomerulonephritis .
3126735	0	TGF_beta	0,8	c-fos	29,34	TGF beta	c-fos	59086(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TGF_beta induces a sustained c-fos expression associated with stimulation or inhibition of cell growth in EL2 or NIH 3T3 fibroblasts .
9330712	0	TGF_beta	48,56	proteinase_3	63,75	TGF beta	proteinase 3	7040	5657	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of transforming_growth_factor_beta -LRB- TGF_beta -RRB- with proteinase_3 .
16891311	0	TGF_beta	78,86	transforming_growth_factor-beta	45,76	TGF beta	transforming growth factor-beta	7040	7040	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Requirement of Smad3 and CREB-1 in mediating transforming_growth_factor-beta -LRB- TGF_beta -RRB- induction of TGF_beta 3 secretion .
2169765	0	TGF_beta	52,60	transforming_growth_factor_beta	19,50	TGF beta	transforming growth factor beta	7040	7040	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Protective role of transforming_growth_factor_beta -LRB- TGF_beta -RRB- in tumor-induced degradation of basement membranes .
8120044	0	TGF_beta	79,87	transforming_growth_factor_beta	46,77	TGF beta	transforming growth factor beta	7040	7040	Gene	Gene	complexes|appos|START_ENTITY complexes|amod|END_ENTITY	Characterization and autoregulation of latent transforming_growth_factor_beta -LRB- TGF_beta -RRB- complexes in osteoblast-like cell lines .
8268968	0	TGF_beta	41,49	transforming_growth_factor_beta	8,39	TGF beta	transforming growth factor beta	7040	7040	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of transforming_growth_factor_beta -LRB- TGF_beta -RRB- in systemic autoimmunity .
8388229	0	TGF_beta	47,55	transforming_growth_factor_beta	14,45	TGF beta	transforming growth factor beta	7040	7040	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Expression of transforming_growth_factor_beta -LRB- TGF_beta -RRB- receptors and expression of TGF_beta_1 , TGF_beta_2 and TGF_beta 3 in human small_cell_lung_cancer_cell lines .
9330712	0	TGF_beta	48,56	transforming_growth_factor_beta	15,46	TGF beta	transforming growth factor beta	7040	7040	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of transforming_growth_factor_beta -LRB- TGF_beta -RRB- with proteinase_3 .
12489180	0	TGF_beta-1	0,10	DMP-1	25,30	TGF beta-1	DMP-1	21803(Tax:10090)	13406(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	TGF_beta-1 downregulates DMP-1 and DSPP in odontoblasts .
9437047	0	TGF_beta-1	0,10	TGF_beta-1	134,144	TGF beta-1	TGF beta-1	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	TGF_beta-1 mRNA expression and proliferation of human osteoblastic cells in nonosteoporotic and osteoporotic women under influence of TGF_beta-1 and IGF-I .
9437047	0	TGF_beta-1	134,144	TGF_beta-1	0,10	TGF beta-1	TGF beta-1	7040	7040	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	TGF_beta-1 mRNA expression and proliferation of human osteoblastic cells in nonosteoporotic and osteoporotic women under influence of TGF_beta-1 and IGF-I .
9787404	0	TGF_beta_1	74,84	EGF	58,61	TGF beta 1	EGF	7040	1950	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
7511881	0	TGF_beta_1	176,186	IFN_beta	187,195	TGF beta 1	IFN beta	7040	3456	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interferon treatment enhances the expression of underphosphorylated -LRB- biologically-active -RRB- retinoblastoma protein in human_papilloma_virus-infected cells through the inhibitory TGF_beta_1 / IFN_beta cytokine pathway .
9787404	0	TGF_beta_1	74,84	TGF_alpha	63,72	TGF beta 1	TGF alpha	7040	7039	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
11263238	0	TGF_beta_1	10,20	TGF_beta_2	22,32	TGF beta 1	TGF beta 2	100873157	421352(Tax:9031)	Gene	Gene	Study|nmod|START_ENTITY Study|appos|END_ENTITY	-LSB- Study on TGF_beta_1 , TGF_beta_2 , TGF_beta_3 expression in the chick_basilar_papilla following gentamicin toxicity -RSB- .
2015789	0	TGF_beta_1	27,37	beta_2_and_beta_3	39,56	TGF beta 1	beta 2 and beta 3	21803(Tax:10090)	15130(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Differential expression of TGF_beta_1 , beta_2_and_beta_3 genes during mouse embryogenesis .
9787404	0	TGF_beta_1	74,84	glucocorticoid_receptor	19,42	TGF beta 1	glucocorticoid receptor	7040	2908	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
12489179	0	TGF_beta_1	0,10	osteoadherin	40,52	TGF beta 1	osteoadherin	7040	4958	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	TGF_beta_1 signaling and stimulation of osteoadherin in human odontoblasts in vitro .
9138446	0	TGF_beta_2	0,10	CD4	50,53	TGF beta 2	CD4	7042	100009152(Tax:9986)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TGF_beta_2 in rabbit blastocoelic fluid regulates CD4 membrane expression : possible role in the success of gestation .
11263238	0	TGF_beta_2	22,32	TGF_beta_1	10,20	TGF beta 2	TGF beta 1	421352(Tax:9031)	100873157	Gene	Gene	Study|appos|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study on TGF_beta_1 , TGF_beta_2 , TGF_beta_3 expression in the chick_basilar_papilla following gentamicin toxicity -RSB- .
9491776	0	TGFalpha	137,145	EGF	112,115	TGFalpha	EGF	7039	1950	Gene	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	Response to transforming_growth_factor_alpha -LRB- TGFalpha -RRB- and epidermal_growth_factor -LRB- EGF -RRB- in hepatocytes : lower EGF receptor affinity of TGFalpha is associated with more sustained activation of p42/p44 mitogen-activated_protein kinase and greater efficacy in stimulation of DNA synthesis .
10557079	0	TGFalpha	45,53	EGF/TGFalpha	4,16	TGFalpha	EGF/TGFalpha	7039	1950;7039	Gene	Gene	promoter|compound|START_ENTITY element|nmod|promoter element|compound|END_ENTITY	The EGF/TGFalpha response element within the TGFalpha promoter consists of a multi-complex regulatory element .
21170088	0	TGFb	24,28	ADAM17	0,6	TGFb	ADAM17	7040	6868	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	ADAM17 -LRB- TACE -RRB- regulates TGFb signaling through the cleavage of vasorin .
25589515	0	TGFb	54,58	Activating_transcription_factor_3	0,33	TGFb	Activating transcription factor 3	21803(Tax:10090)	11910(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Activating_transcription_factor_3 regulates canonical TGFb signalling in systemic_sclerosis .
24812125	0	TGFb	51,55	Adam17	20,26	TGFb	Adam17	21803(Tax:10090)	11491(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|variants variants|nmod|END_ENTITY	Genetic variants of Adam17 differentially regulate TGFb signaling to modify vascular pathology in mice and humans .
26596284	0	TGFb	17,21	CDKN2B	0,6	TGFb	CDKN2B	7040	1030	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	CDKN2B Regulates TGFb Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels .
26169354	0	TGFb	16,20	CIN85	0,5	TGFb	CIN85	7040	30011	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	CIN85 modulates TGFb signaling by promoting the presentation of TGFb receptors on the cell surface .
26169354	0	TGFb	64,68	CIN85	0,5	TGFb	CIN85	7040	30011	Gene	Gene	receptors|compound|START_ENTITY presentation|nmod|receptors promoting|dobj|presentation signaling|advcl|promoting TGFb|acl|signaling modulates|dobj|TGFb modulates|nsubj|END_ENTITY	CIN85 modulates TGFb signaling by promoting the presentation of TGFb receptors on the cell surface .
20622901	0	TGFb	33,37	Fbxw7	17,22	TGFb	Fbxw7	7040	55294	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Tumor suppressor Fbxw7 regulates TGFb signaling by targeting TGIF1 for degradation .
25249657	0	TGFb	58,62	Fibroblast_growth_factor_receptor_1	0,35	TGFb	Fibroblast growth factor receptor 1	7040	2260	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Fibroblast_growth_factor_receptor_1 is a key inhibitor of TGFb signaling in the endothelium .
22278742	0	TGFb	53,57	GARP	0,4	TGFb	GARP	7040	2615	Gene	Gene	bioavailability|nmod|START_ENTITY regulates|dobj|bioavailability regulates|nsubj|END_ENTITY	GARP regulates the bioavailability and activation of TGFb .
27054568	0	TGFb	26,30	GARP	12,16	TGFb	GARP	7040	2615	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	How Soluble GARP Enhances TGFb Activation .
23748100	0	TGFb	45,49	Gremlin	0,7	TGFb	Gremlin	7040	26585	Gene	Gene	utilizes|dobj|START_ENTITY utilizes|nsubj|END_ENTITY	Gremlin utilizes canonical and non-canonical TGFb signaling to induce lysyl_oxidase -LRB- LOX -RRB- genes in human trabecular meshwork cells .
24945737	0	TGFb	16,20	IL-10	22,27	TGFb	IL-10	7040	3586	Gene	Gene	IL-17|compound|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TGFb , IL-10 , IL-17 , and IL-23 cytokines in b-thalassemia major patients : the impact of silymarin therapy .
25882815	0	TGFb	20,24	KLF4	12,16	TGFb	KLF4	7040	9314	Gene	Gene	responses|compound|START_ENTITY role|nmod|responses role|nmod|END_ENTITY	The role of KLF4 in TGFb induced inflammatory and fibrotic responses in human proximal tubule cells .
20974850	0	TGFb	23,27	LKB1	52,56	TGFb	LKB1	7040	6794	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of TGFb signaling by the kinase LKB1 and the scaffolding protein LIP1 .
26571030	0	TGFb	27,31	MAP1S	83,88	TGFb	MAP1S	7040	55201	Gene	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Transforming Growth Factor TGFb Increases Levels of Microtubule-Associated Protein MAP1S and Autophagy Flux in Pancreatic_Ductal_Adenocarcinomas .
22899851	0	TGFb	35,39	Myocardin-like_protein_2	0,24	TGFb	Myocardin-like protein 2	7040	57496	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Myocardin-like_protein_2 regulates TGFb signaling in embryonic stem cells and the developing vasculature .
24071738	0	TGFb	15,19	OTUB1	0,5	TGFb	OTUB1	7040	55611	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	OTUB1 enhances TGFb signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3 .
25227666	0	TGFb	15,19	Pttg1	0,5	TGFb	Pttg1	7040	9232	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Pttg1 inhibits TGFb signaling in breast_cancer cells to promote their growth .
27054113	0	TGFb	87,91	SMAD3	32,37	TGFb	SMAD3	7040	4088	Gene	Gene	Pathway|compound|START_ENTITY Supports|nmod|Pathway Supports|nsubj|Interaction Interaction|nmod|Transcript Transcript|compound|END_ENTITY	Hsa-miR-590-5p Interaction with SMAD3 Transcript Supports Its Regulatory Effect on The TGFb Signaling Pathway .
23633623	0	TGFb	22,26	SMAD7	0,5	TGFb	SMAD7	21803(Tax:10090)	17131(Tax:10090)	Gene	Gene	superfamily|compound|START_ENTITY antagonizes|dobj|superfamily antagonizes|nsubj|END_ENTITY	SMAD7 antagonizes key TGFb superfamily signaling in mouse granulosa cells in vitro .
23709694	0	TGFb	15,19	SMAD7	61,66	TGFb	SMAD7	21803(Tax:10090)	17131(Tax:10090)	Gene	Gene	sensitivity|compound|START_ENTITY mediates|dobj|sensitivity mediates|advcl|downregulating downregulating|dobj|END_ENTITY	Cbl-b mediates TGFb sensitivity by downregulating inhibitory SMAD7 in primary T cells .
24244446	0	TGFb	127,131	Smad3	93,98	TGFb	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	sodium_sulfate-induced|nmod|START_ENTITY sodium_sulfate-induced|nmod|mice mice|amod|END_ENTITY	Characterization of dextran sodium_sulfate-induced inflammation and colonic tumorigenesis in Smad3 -LRB- - / - -RRB- mice with dysregulated TGFb .
26639428	0	TGFb	0,4	Smad3	55,60	TGFb	Smad3	7040	4088	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TGFb regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells : implications in intervertebral_disc_degeneration .
23959527	0	TGFb	16,20	Smad7	0,5	TGFb	Smad7	59086(Tax:10116)	81516(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Smad7 modulates TGFb signaling during cranial suture development to maintain suture patency .
26053644	0	TGFb	23,27	Stem_Cell_Antigen-1	41,60	TGFb	Stem Cell Antigen-1	21803(Tax:10090)	110454(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Negative Regulation of TGFb Signaling by Stem_Cell_Antigen-1 Protects against Ischemic_Acute_Kidney_Injury .
26918958	0	TGFb	40,44	TGFb	68,72	TGFb	TGFb	7040	7040	Gene	Gene	Protein|compound|START_ENTITY Protein|nmod|END_ENTITY	Genotype-Specific Interaction of Latent TGFb Binding Protein 4 with TGFb .
26918958	0	TGFb	68,72	TGFb	40,44	TGFb	TGFb	7040	7040	Gene	Gene	Protein|nmod|START_ENTITY Protein|compound|END_ENTITY	Genotype-Specific Interaction of Latent TGFb Binding Protein 4 with TGFb .
26992552	0	TGFb	65,69	Thrombospondin-1	0,16	TGFb	Thrombospondin-1	7040	7057	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Thrombospondin-1 promotes mesenchymal stromal cell functions via TGFb and in cooperation with PDGF .
21364658	0	TGFb	31,35	UCP2	23,27	TGFb	UCP2	7040	7351	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Negative regulation of UCP2 by TGFb signaling characterizes low and intermediate-grade primary breast_cancer .
22773947	0	TGFb	15,19	USP11	0,5	TGFb	USP11	7040	8237	Gene	Gene	augments|dobj|START_ENTITY augments|nsubj|END_ENTITY	USP11 augments TGFb signalling by deubiquitylating ALK5 .
24501422	0	TGFb	50,54	miR-218	0,7	TGFb	miR-218	21803(Tax:10090)	387214(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	miR-218 regulates focal_adhesion_kinase-dependent TGFb signaling in fibroblasts .
26487755	0	TGFb	89,93	p16	108,111	TGFb	p16	7040	1029	Gene	Gene	Regulation|compound|START_ENTITY Regulation|nmod|Expression Expression|amod|END_ENTITY	9p21 .3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent TGFb Regulation of p16 Expression in Human Aortic Smooth Muscle Cells .
23250756	0	TGFb	125,129	transforming_growth_factor-b	95,123	TGFb	transforming growth factor-b	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	The transcription factor paired-related_homeobox_1 -LRB- Prrx1 -RRB- inhibits adipogenesis by activating transforming_growth_factor-b -LRB- TGFb -RRB- signaling .
21321980	0	TGFb	45,49	transforming_growth_factor-beta	12,43	TGFb	transforming growth factor-beta	7040	7040	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Blockade of transforming_growth_factor-beta -LRB- TGFb -RRB- signaling inhibits osteoblastic tumorigenesis by a novel human prostate_cancer cell line .
21170088	0	TGFb	24,28	vasorin	63,70	TGFb	vasorin	7040	114990	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cleavage cleavage|nmod|END_ENTITY	ADAM17 -LRB- TACE -RRB- regulates TGFb signaling through the cleavage of vasorin .
24747824	0	TGFb1	38,43	ANRIL	0,5	TGFb1	ANRIL	7040	100048912	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	ANRIL inhibits p15 -LRB- INK4b -RRB- through the TGFb1 signaling pathway in human esophageal_squamous_cell_carcinoma .
21658938	0	TGFb1	61,66	CCL5	21,25	TGFb1	CCL5	7040	6352	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between CCL5 and transforming_growth_factor-b1 -LRB- TGFb1 -RRB- in breast_cancer .
22732080	0	TGFb1	108,113	CTGF	27,31	TGFb1	CTGF	7040	1490	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Differential expression of CTGF in pre - and post-ovulatory granulosa cells in the hen ovary is regulated by TGFb1 and gonadotrophins .
25057110	0	TGFb1	38,43	Cyp19a1	60,67	TGFb1	Cyp19a1	59086(Tax:10116)	25147(Tax:10116)	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Calcineurin and CRTC2 mediate FSH and TGFb1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells .
23185371	0	TGFb1	39,44	GLI1	25,29	TGFb1	GLI1	7040	2735	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	The transcription factor GLI1 mediates TGFb1 driven EMT in hepatocellular_carcinoma via a SNAI1-dependent mechanism .
25514442	0	TGFb1	58,63	IGF-R1	81,87	TGFb1	IGF-R1	59086(Tax:10116)	25718(Tax:10116)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Chronic lung_injury in the neonatal rat : Up-regulation of TGFb1 and nitration of IGF-R1 by peroxynitrite as likely contributors to impaired alveologenesis .
20607798	0	TGFb1	0,5	IL-6	14,18	TGFb1	IL-6	7040	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TGFb1 induces IL-6 and inhibits IL-8 release in human bronchial epithelial cells : the role of Smad2/3 .
21345218	0	TGFb1	0,5	MAD1	15,19	TGFb1	MAD1	7040	4084	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TGFb1 enhances MAD1 expression and stimulates promoter-bound Pol II phosphorylation : basic functions of C/EBP , SP and SMAD3 transcription factors .
25162823	0	TGFb1	32,37	MRC2	0,4	TGFb1	MRC2	7040	9902	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|compound|END_ENTITY	MRC2 expression correlates with TGFb1 and survival in hepatocellular_carcinoma .
25596283	0	TGFb1	24,29	SND1	0,4	AEG-1	SND1	92140	27044	Gene	Gene	Downstream|nmod|START_ENTITY Downstream|compound|END_ENTITY	SND1 Acts Downstream of TGFb1 and Upstream of Smurf1 to Promote Breast_Cancer_Metastasis .
22997505	0	TGFb1	0,5	Smad3	91,96	TGFb1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Signaling Signaling|compound|END_ENTITY	TGFb1 Controls PPARy Expression , Transcriptional Potential , and Activity , in Part , through Smad3 Signaling in Murine Lung Fibroblasts .
25585026	0	TGFb1	0,5	Src	24,27	TGFb1	Src	21803(Tax:10090)	20779(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TGFb1 rapidly activates Src through a non-canonical redox signaling mechanism .
26461366	0	TGFb1	0,5	Src	24,27	TGFb1	Src	7040	6714	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TGFb1 rapidly activates Src through a non-canonical redox mechanism .
23917667	0	TGFb1	57,62	transforming_growth_factor_b1	26,55	TGFb1	transforming growth factor b1	282089(Tax:9913)	282089(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin_10 -LRB- IL10 -RRB- and transforming_growth_factor_b1 -LRB- TGFb1 -RRB- gene polymorphisms in persistent IgE-mediated cow 's milk_allergy .
24628581	0	TGFb1	65,70	transforming_growth_factor_b1	34,63	TGFb1	transforming growth factor b1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential neuroprotective role of transforming_growth_factor_b1 -LRB- TGFb1 -RRB- in the brain .
22503347	0	TGFb1	72,77	transforming_growth_factor_beta-1	37,70	TGFb1	transforming growth factor beta-1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter region polymorphisms in the transforming_growth_factor_beta-1 -LRB- TGFb1 -RRB- gene and serum TGFb1 concentration in preeclamptic and control Iranian women .
23597094	0	TGFb1	92,97	transforming_growth_factor_beta_1	57,90	TGFb1	transforming growth factor beta 1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Gene-environment interaction between body mass index and transforming_growth_factor_beta_1 -LRB- TGFb1 -RRB- gene in knee and hip_osteoarthritis .
25448845	0	TGFb2	0,5	TGFb_inducible_early_gene-1	56,83	TGFb2	TGFb inducible early gene-1	21808(Tax:10090)	21847(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TGFb2 regulates hypothalamic Trh expression through the TGFb_inducible_early_gene-1 -LRB- TIEG1 -RRB- during fetal development .
25448845	0	TGFb2	0,5	Trh	29,32	TGFb2	Trh	21808(Tax:10090)	22044(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TGFb2 regulates hypothalamic Trh expression through the TGFb_inducible_early_gene-1 -LRB- TIEG1 -RRB- during fetal development .
26788063	0	TGFb3	90,95	CD24	14,18	TGFb3	CD24	7043	100133941	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of CD24 in Human Bone Marrow-Derived Mesenchymal Stromal Cells Is Regulated by TGFb3 and Induces a Myofibroblast-Like Genotype .
26612435	0	TGFb3	0,5	TGFB3	7,12	TGFb3	TGFB3	7043	7043	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	TGFb3 -LRB- TGFB3 -RRB- polymorphism is associated with male_infertility .
24323465	0	TGFbIp	60,66	Periostin	0,9	TGFbIp	Periostin	21810(Tax:10090)	50706(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Periostin and transforming growth factor b-induced protein -LRB- TGFbIp -RRB- are both expressed by osteoblasts and osteoclasts .
24606633	0	TGFbR2	0,6	miR-93	28,34	TGFbR2	miR-93	7048	407051	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	TGFbR2 is a major target of miR-93 in nasopharyngeal_carcinoma aggressiveness .
25448845	0	TGFb_inducible_early_gene-1	56,83	TGFb2	0,5	TGFb inducible early gene-1	TGFb2	21847(Tax:10090)	21808(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TGFb2 regulates hypothalamic Trh expression through the TGFb_inducible_early_gene-1 -LRB- TIEG1 -RRB- during fetal development .
12718878	0	TGFbeta	16,23	ATF3	98,102	TGFbeta	ATF3	7040	467	Gene	Gene	response|compound|START_ENTITY response|dep|END_ENTITY	A self-enabling TGFbeta response coupled to stress signaling : Smad engages stress response factor ATF3 for Id1 repression in epithelial cells .
17349636	0	TGFbeta	20,27	Bcr-Abl	50,57	TGFbeta	Bcr-Abl	7040	25	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Upregulation of the TGFbeta signalling pathway by Bcr-Abl : implications for haemopoietic cell growth and chronic_myeloid_leukaemia .
17360654	0	TGFbeta	0,7	CD16	31,35	TGFbeta	CD16	7040	2214	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|conversion conversion|nmod|cells cells|nummod|END_ENTITY	TGFbeta promotes conversion of CD16 + peripheral blood NK cells into CD16 - NK cells with similarities to decidual NK cells .
17360654	0	TGFbeta	0,7	CD16	68,72	TGFbeta	CD16	7040	2214	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	TGFbeta promotes conversion of CD16 + peripheral blood NK cells into CD16 - NK cells with similarities to decidual NK cells .
15654963	0	TGFbeta	0,7	CD1d	17,21	TGFbeta	CD1d	7040	912	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TGFbeta inhibits CD1d expression on dendritic cells .
15265695	0	TGFbeta	0,7	CFTR	31,35	TGFbeta	CFTR	7040	1080	Gene	Gene	down-regulation|compound|START_ENTITY down-regulation|nmod|END_ENTITY	TGFbeta down-regulation of the CFTR : a means to limit epithelial chloride secretion .
17915216	0	TGFbeta	0,7	CTGF	56,60	TGFbeta	CTGF	7040	1490	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling .
17203972	0	TGFbeta	88,95	Epac1	109,114	TGFbeta	Epac1	7040	10411	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Interactome of transforming_growth_factor-beta type I receptor -LRB- TbetaRI -RRB- : inhibition of TGFbeta signaling by Epac1 .
11451566	0	TGFbeta	54,61	FoxH1	44,49	TGFbeta	FoxH1	7040	8928	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The transcriptional role of Smads and FAST -LRB- FoxH1 -RRB- in TGFbeta and activin signalling .
18591668	0	TGFbeta	23,30	Hsp90	44,49	TGFbeta	Hsp90	7040	3320	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Critical regulation of TGFbeta signaling by Hsp90 .
18475727	0	TGFbeta	63,70	IL-10	49,54	TGFbeta	IL-10	7040	3586	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Regulation by anti-inflammatory cytokines -LRB- IL-4 , IL-10 , IL-13 , TGFbeta -RRB- of interleukin-8 production by LPS - and / or TNFalpha-activated human polymorphonuclear cells .
19587162	0	TGFbeta	18,25	IL-1beta	0,8	TGFbeta	IL-1beta	21803(Tax:10090)	16176(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IL-1beta inhibits TGFbeta in the temporomandibular_joint .
18475727	0	TGFbeta	63,70	IL-4	43,47	TGFbeta	IL-4	7040	3565	Gene	Gene	IL-13|dep|START_ENTITY IL-13|compound|END_ENTITY	Regulation by anti-inflammatory cytokines -LRB- IL-4 , IL-10 , IL-13 , TGFbeta -RRB- of interleukin-8 production by LPS - and / or TNFalpha-activated human polymorphonuclear cells .
17329363	0	TGFbeta	44,51	MAN1	29,33	TGFbeta	MAN1	21803(Tax:10090)	380664(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	The nuclear envelope protein MAN1 regulates TGFbeta signaling and vasculogenesis in the embryonic yolk sac .
21084277	0	TGFbeta	51,58	PRL-3	12,17	TGFbeta	PRL-3	7040	11156	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Phosphatase PRL-3 is a direct regulatory target of TGFbeta in colon_cancer metastasis .
15761148	0	TGFbeta	43,50	Par6	35,39	TGFbeta	Par6	7040	100506965	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity .
18725536	0	TGFbeta	0,7	SIK	16,19	TGFbeta	SIK	7040	150094	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TGFbeta induces SIK to negatively regulate type I receptor kinase signaling .
18789926	0	TGFbeta	0,7	Wnt	17,20	TGFbeta	Wnt	59086(Tax:10116)	114487(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	TGFbeta promotes Wnt expression during cataract development .
12568406	0	TGFbeta	116,123	betaglycan	81,91	TGFbeta	betaglycan	7040	7049	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner .
10364455	0	TGFbeta	46,53	haptoglobin	15,26	TGFbeta	haptoglobin	59086(Tax:10116)	24464(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Attenuation of haptoglobin gene expression by TGFbeta requires the MAP kinase pathway .
19088080	0	TGFbeta	50,57	transforming_growth_factor-beta	17,48	TGFbeta	transforming growth factor-beta	7040	7040	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Silencing of the transforming_growth_factor-beta -LRB- TGFbeta -RRB- receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling .
19787707	0	TGFbeta	45,52	transforming_growth_factor-beta	12,43	TGFbeta	transforming growth factor-beta	7040	7040	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	The tale of transforming_growth_factor-beta -LRB- TGFbeta -RRB- signaling : a soign enigma .
12707256	0	TGFbeta	147,154	transforming_growth_factor_beta	61,92	TGFbeta	transforming growth factor beta	21803(Tax:10090)	7040	Gene	Gene	activation|nmod|START_ENTITY paradoxical|dobj|activation leads|xcomp|paradoxical leads|nsubj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Fibroblast-specific expression of a kinase-deficient type II transforming_growth_factor_beta -LRB- TGFbeta -RRB- receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic_mice .
12707256	0	TGFbeta	94,101	transforming_growth_factor_beta	61,92	TGFbeta	transforming growth factor beta	21803(Tax:10090)	7040	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Fibroblast-specific expression of a kinase-deficient type II transforming_growth_factor_beta -LRB- TGFbeta -RRB- receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic_mice .
18353867	0	TGFbeta	0,7	transglutaminase_2	31,49	TGFbeta	transglutaminase 2	21803(Tax:10090)	21817(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	TGFbeta mediates activation of transglutaminase_2 in response to oxidative stress that leads to protein_aggregation .
9599024	0	TGFbeta-receptor_interacting_protein-1	56,94	TRIP-1	96,102	TGFbeta-receptor interacting protein-1	TRIP-1	8668	8668	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosomal location of the human TGFbeta-receptor_interacting_protein-1 -LRB- TRIP-1 -RRB- gene to 1p34 .1 .
17242066	0	TGFbeta1	45,53	Fibrillin-1	0,11	TGFbeta1	Fibrillin-1	7040	2200	Gene	Gene	bioavailability|nmod|START_ENTITY regulates|dobj|bioavailability regulates|nsubj|END_ENTITY	Fibrillin-1 regulates the bioavailability of TGFbeta1 .
10585285	0	TGFbeta1	39,47	IGF-II	0,6	TGFbeta1	IGF-II	7040	3481	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	IGF-II enhances trichostatin_A-induced TGFbeta1 and p21 -LRB- Waf1 , Cip1 , sdi1 -RRB- expression in Hep3B cells .
20169621	0	TGFbeta1	0,8	Jagged1	17,24	TGFbeta1	Jagged1	7040	182	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation .
18615188	0	TGFbeta1	45,53	PPARgamma	21,30	TGFbeta1	PPARgamma	7040	5468	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	A Novel Mechanism of PPARgamma Regulation of TGFbeta1 : Implication in Cancer Biology .
16256024	0	TGFbeta1	12,20	SP1	56,59	TGFbeta1	SP1	59086(Tax:10116)	24790(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	-LSB- Effects of TGFbeta1 on the transcriptional activity of SP1 , AP1 and Smad3-Smad4 in lung fibroblasts -RSB- .
16253118	0	TGFbeta1	75,83	Smad2	25,30	TGFbeta1	Smad2	7040	4087	Gene	Gene	responses|amod|START_ENTITY regulation|nmod|responses role|nmod|regulation role|nmod|END_ENTITY	The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells .
12581383	0	TGFbeta1	34,42	Transforming_growth_factor_beta1	0,32	TGFbeta1	Transforming growth factor beta1	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor_beta1 -LRB- TGFbeta1 -RRB- expression in head_and_neck_squamous_cell_carcinoma patients as related to prognosis .
19136278	0	TGFbeta1	35,43	Transforming_growth_factor_beta_1	0,33	TGFbeta1	Transforming growth factor beta 1	7040	7040	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGFbeta1 -RRB- gene polymorphisms and Chagas_disease susceptibility in Peruvian and Colombian patients .
14572313	0	TGFbeta1	0,8	c-Jun	19,24	TGFbeta1	c-Jun	7040	3725	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin .
9109442	0	TGFbeta1	0,8	furin	64,69	TGFbeta1	furin	59086(Tax:10116)	54281(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	TGFbeta1 regulates gene expression of its own converting enzyme furin .
11592306	0	TGFbeta1	0,8	matrix_metalloproteinase_2	37,63	TGFbeta1	matrix metalloproteinase 2	7040	4313	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	TGFbeta1 stimulates the secretion of matrix_metalloproteinase_2 -LRB- MMP2 -RRB- and the invasive behavior in human ovarian_cancer cells , which is suppressed by MMP inhibitor BB3103 .
15934312	0	TGFbeta1	23,31	smad2	53,58	TGFbeta1	smad2	59086(Tax:10116)	29357(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of exogenous TGFbeta1 on the expression of smad2 and smad3 in rat bone marrow-derived mesenchymal stem cells .
16686283	0	TGFbeta1	47,55	transforming_growth_factor_beta	14,45	TGFbeta1	transforming growth factor beta	7040	7040	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibition of transforming_growth_factor_beta -LRB- TGFbeta1 -RRB- expression and extracellular matrix secretion in human peritoneal mesothelial cells by pcDU6 vector-mediated TGFbeta1 shRNA and by pcDNA3 .1 -LRB- - -RRB- - mediated antisense TGFbeta1 RNA .
11675471	0	TGFbeta1	52,60	transforming_growth_factor_beta1	18,50	TGFbeta1	transforming growth factor beta1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Quantification of transforming_growth_factor_beta1 -LRB- TGFbeta1 -RRB- mRNA expression in mouse preimplantation embryos and determination of TGFbeta receptor -LRB- type I and type II -RRB- expression in mouse embryos and reproductive tract .
15015581	0	TGFbeta1	124,132	transforming_growth_factor_beta1	90,122	TGFbeta1	transforming growth factor beta1	7040	7040	Gene	Gene	signal|appos|START_ENTITY signal|amod|END_ENTITY	The inhibitory effects of gossypol on human prostate_cancer cells-PC3 are associated with transforming_growth_factor_beta1 -LRB- TGFbeta1 -RRB- signal transduction pathway .
16787918	0	TGFbeta2	21,29	Pax3	33,37	TGFbeta2	Pax3	21808(Tax:10090)	18505(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of murine TGFbeta2 by Pax3 during early embryonic development .
10864463	0	TGFbeta2	31,39	Slug	0,4	TGFbeta2	Slug	421352(Tax:9031)	432368(Tax:9031)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Slug is an essential target of TGFbeta2 signaling in the developing chicken heart .
17452626	0	TGFbeta3	0,8	E-cadherin	18,28	TGFbeta3	E-cadherin	21809(Tax:10090)	12550(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF1 transcription complex .
18461597	0	TGFbeta3	33,41	ROCK1	0,5	TGFbeta3	ROCK1	396438(Tax:9031)	373970(Tax:9031)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation .
9671313	0	TGFbeta3	12,20	p27Kip1	38,45	TGFbeta3	p27Kip1	7043	1027	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Blockade of TGFbeta3 up-regulation of p27Kip1 and p21Cip1 by expression of RasN17 in epithelial cells .
19836147	0	TGFbeta3	164,172	vascular_endothelial_growth_factor	14,48	TGFbeta3	vascular endothelial growth factor	7043	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , hypoxia_inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- , and transforming growth factors beta1 -LRB- TGFbeta1 -RRB- and beta3 -LRB- TGFbeta3 -RRB- in gestational_trophoblastic_disease .
14709802	0	TGFbeta_1	67,76	7B2	44,47	TGFbeta 1	7B2	7040	6447	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cell growth and expression of 7B2 , PC2 , and PC1/3 by TGFbeta_1 and sodium_butyrate in a human pituitary cell line -LRB- HP75 -RRB- .
11571228	0	TGIF	37,41	mSin3	51,56	TGIF	mSin3	7050	20466(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The Smad transcriptional corepressor TGIF recruits mSin3 .
18210215	0	TGIF	19,23	p21	47,50	TGIF	p21	7050	1026	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression .
15223781	0	TGIF	66,70	transforming_growth_beta-induced_factor	25,64	TGIF	transforming growth beta-induced factor	7050	7050	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence variants in the transforming_growth_beta-induced_factor -LRB- TGIF -RRB- gene are not associated with high_myopia .
3141056	0	TGIF	45,49	tumor_growth_inhibitory_factor	13,43	TGIF	tumor growth inhibitory factor	3586	3586	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of tumor_growth_inhibitory_factor -LRB- TGIF -RRB- in human mononuclear cells by OK-432 , a streptococcal preparation .
11427533	0	TGIF2	0,5	histone_deacetylase_1	21,42	TGIF2	histone deacetylase 1	60436	3065	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TGIF2 interacts with histone_deacetylase_1 and represses transcription .
3961413	0	TGL	28,31	thyroglobulin	13,26	TGL	thyroglobulin	7038	7038	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The value of thyroglobulin -LRB- TGL -RRB- assay in following the post-therapeutic course of differentiated thyroid_cancer .
18174247	0	TGM2	29,33	transglutaminase_2	4,22	TGM2	transglutaminase 2	7052	7052	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The transglutaminase_2 gene -LRB- TGM2 -RRB- , a potential molecular marker for chemotherapeutic drug sensitivity , is epigenetically silenced in breast_cancer .
10580145	0	TGM4	106,110	prostate-specific_transglutaminase	65,99	TGM4	prostate-specific transglutaminase	7047	7047	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An Sp1 binding site is essential for basal activity of the human prostate-specific_transglutaminase gene -LRB- TGM4 -RRB- promoter .
9721214	0	TGM4	51,55	prostate-specific_transglutaminase	10,44	TGM4	prostate-specific transglutaminase	7047	7047	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human prostate-specific_transglutaminase gene -LRB- TGM4 -RRB- : genomic organization , tissue-specific expression , and promoter characterization .
12586211	0	TGR	111,114	mREN2	115,120	TGR	mREN2	232223(Tax:10090)	19702(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene -LRB- TGR -LSB- mREN2 -RSB- 27 -RRB- .
8557967	0	TGR	36,39	mREN2	40,45	TGR	mREN2	232223(Tax:10090)	19702(Tax:10090)	Gene	Gene	27|compound|START_ENTITY 27|appos|END_ENTITY	Angiotensin_II receptor blockade in TGR -LRB- mREN2 -RRB- 27 : effects of renin-angiotensin-system gene expression and cardiovascular functions .
9605382	0	TGR	74,77	mREN2	78,83	TGR	mREN2	232223(Tax:10090)	19702(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|rats rats|dep|END_ENTITY	Differential development of early hypertension in heterozygous transgenic TGR -LRB- mREN2 -RRB- 27 rats .
26208278	0	TGR5	8,12	GLP-1	38,43	TGR5	GLP-1	227289(Tax:10090)	14526(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic b-Cells in Type 2 Diabetic Mice .
26208278	0	TGR5	8,12	GLP-1	38,43	TGR5	GLP-1	227289(Tax:10090)	14526(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY Secretion|compound|END_ENTITY	A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic b-Cells in Type 2 Diabetic Mice .
20236244	0	TGR5	58,62	GpBAR1	50,56	TGR5	GpBAR1	227289(Tax:10090)	227289(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of the bile_acid receptor GpBAR1 -LRB- TGR5 -RRB- in the murine enteric nervous system .
26107166	0	TGR5	73,77	miR-26a	18,25	TGR5	miR-26a	227289(Tax:10090)	387218(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of miR-26a as a Target Gene of Bile_Acid Receptor GPBAR-1 / TGR5 .
17552366	0	TGase-4	45,52	prostate_transglutaminase	18,43	TGase-4	prostate transglutaminase	7047	7047	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the prostate_transglutaminase -LRB- TGase-4 -RRB- in prostate_cancer cells and its impact on the invasiveness of prostate_cancer .
23508200	0	TH	51,53	Nurr1	55,60	TH	Nurr1	25085(Tax:10116)	54278(Tax:10116)	Gene	Gene	Genes|compound|START_ENTITY Genes|dep|END_ENTITY	Spontaneous Expression of Neurotrophic Factors and TH , Nurr1 , Nestin Genes in Long-term Culture of Bone Marrow Mesenchymal Stem Cells .
7909910	0	TH	99,101	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	TH	Pituitary adenylate cyclase activating polypeptide	280707(Tax:9913)	615187(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- potently enhances tyrosine_hydroxylase -LRB- TH -RRB- expression in adrenal chromaffin cells .
11207940	0	TH	68,70	tyrosine_hydroxylase	46,66	TH	tyrosine hydroxylase	25085(Tax:10116)	25085(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of chronic bromocriptine treatment on tyrosine_hydroxylase -LRB- TH -RRB- mRNA expression , TH activity and median eminence dopamine concentrations in ageing rats .
11207940	0	TH	89,91	tyrosine_hydroxylase	46,66	TH	tyrosine hydroxylase	25085(Tax:10116)	25085(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of chronic bromocriptine treatment on tyrosine_hydroxylase -LRB- TH -RRB- mRNA expression , TH activity and median eminence dopamine concentrations in ageing rats .
15744773	0	TH	91,93	tyrosine_hydroxylase	69,89	TH	tyrosine hydroxylase	7054	7054	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Characterization of five evolutionary conserved regions of the human tyrosine_hydroxylase -LRB- TH -RRB- promoter : implications for the engineering of a human TH minimal promoter assembled in a self-inactivating lentiviral vector system .
16210796	0	TH	29,31	tyrosine_hydroxylase	7,27	TH	tyrosine hydroxylase	403444(Tax:9615)	403444(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Canine tyrosine_hydroxylase -LRB- TH -RRB- gene and dopamine_beta _ - hydroxylase -LRB- DBH -RRB- gene : their sequences , genetic polymorphisms , and diversities among five different dog breeds .
18208403	0	TH	59,61	tyrosine_hydroxylase	37,57	TH	tyrosine hydroxylase	7054	7054	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A functional intronic variant in the tyrosine_hydroxylase -LRB- TH -RRB- gene confers risk of essential hypertension in the Northern Chinese Han population .
21310168	0	TH	46,48	tyrosine_hydroxylase	24,44	TH	tyrosine hydroxylase	7054	7054	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of manganese on tyrosine_hydroxylase -LRB- TH -RRB- activity and TH-phosphorylation in a dopaminergic neural cell line .
7909910	0	TH	99,101	tyrosine_hydroxylase	77,97	TH	tyrosine hydroxylase	280707(Tax:9913)	280707(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- potently enhances tyrosine_hydroxylase -LRB- TH -RRB- expression in adrenal chromaffin cells .
10231330	0	TH1	111,114	CD4	43,46	TH1	CD4	51497	920	Gene	Gene	immunity|nummod|START_ENTITY abnormality|nmod|immunity involved|nmod|abnormality involved|nsubjpass|defect defect|nmod|cells cells|compound|END_ENTITY	The quantitative and qualitative defect of CD4 + CD45RO + memory-type T cells are involved in the abnormality of TH1 immunity in atopic_dermatitis patients .
11786644	0	TH1	29,32	CD4	80,83	TH1	CD4	51497	920	Gene	Gene	T-bet|nmod|START_ENTITY effects|nmod|T-bet lineage|nsubj|effects lineage|dobj|production production|nmod|cells cells|compound|END_ENTITY	Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells .
12704370	0	TH1	88,91	CD4	6,9	TH1	CD4	51497	920	Gene	Gene	production|compound|START_ENTITY suppress|dobj|production able|xcomp|suppress able|nsubj|cells cells|compound|END_ENTITY	Human CD4 + CD25 + T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production .
17325053	0	TH1	119,122	CD4	0,3	TH1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY development|nmod|responses function|dobj|development suppress|ccomp|function +|ccomp|suppress +|nsubj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress CD4 + T-cell function and inhibit the development of Plasmodium_berghei-specific TH1 responses involved in cerebral_malaria pathogenesis .
17325053	0	TH1	119,122	CD4	39,42	TH1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY development|nmod|responses function|dobj|development function|nsubj|T-cell T-cell|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress CD4 + T-cell function and inhibit the development of Plasmodium_berghei-specific TH1 responses involved in cerebral_malaria pathogenesis .
18774396	0	TH1	71,74	CD4	90,93	TH1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Oral dendritic cells mediate antigen-specific tolerance by stimulating TH1 and regulatory CD4 + T cells .
19344461	0	TH1	14,17	CD4	9,12	TH1	CD4	51497	920	Gene	Gene	antibodies|compound|START_ENTITY +|dobj|antibodies +|nsubj|END_ENTITY	Indirect CD4 + TH1 response , antidonor antibodies and diffuse C4d graft deposits in long-term recipients conditioned by donor antigens priming .
20463596	0	TH1	5,8	CD4	0,3	TH1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	CD4 + TH1 cells generated by Ii-PADRE DNA at prime phase are important to induce effectors and memory CD8 + T cells .
2905998	1	TH1	207,210	CD4	202,205	TH1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	subset|compound|START_ENTITY subset|compound|END_ENTITY	Evidence for the physiological role of the CD4 + TH1 + subset in mice .
7691279	0	TH1	44,47	CD4	39,42	TH1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	The 3G11 + antigen , a marker for murine CD4 + TH1 lymphocytes , is a ganglioside .
8625361	0	TH1	17,20	CD4	40,43	TH1	CD4	51497	920	Gene	Gene	Disregulation|nmod|START_ENTITY subsets|nsubj|Disregulation subsets|nmod|cells cells|compound|END_ENTITY	Disregulation in TH1 and TH2 subsets of CD4 + T cells in peripheral blood of colorectal_cancer patients and involvement in cancer establishment and progression .
9394724	0	TH1	54,57	CD4	7,10	TH1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY enhance|nsubj|cells T-cell|parataxis|enhance T-cell|nsubj|END_ENTITY	Murine CD4 T-cell response to Helicobacter_infection : TH1 cells enhance gastritis and TH2 cells reduce bacterial load .
7479952	0	TH1	11,14	CD8	36,39	TH1	CD8	51497	925	Gene	Gene	Effects|nmod|START_ENTITY cytokines|nsubj|Effects cytokines|nmod|response response|compound|END_ENTITY	Effects of TH1 and TH2 cytokines on CD8 + cell response against human_immunodeficiency_virus : implications for long-term survival .
16337473	0	TH1	55,58	CXCL10	35,41	TH1	CXCL10	51497	3627	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production .
11298491	0	TH1	38,41	IL-10	0,5	TH1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY mediation|nmod|cell mediation|compound|END_ENTITY	IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid_dysfunction in polymicrobial sepsis .
1648926	0	TH1	40,43	IL-10	12,17	TH1	IL-10	51497	3586	Gene	Gene	responses|compound|START_ENTITY role|nmod|responses role|nmod|END_ENTITY	The role of IL-10 in crossregulation of TH1 and TH2 responses .
2136902	0	TH1	67,70	IL-4	124,128	TH1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY secrete|nmod|cells secrete|parataxis|restored restored|nmod|END_ENTITY	Antigen-specific sIalo B cells do not secrete IgG2a in response to TH1 cells and antigen : responsiveness can be restored by IL-4 .
11397944	0	TH1	31,34	T-bet	8,13	TH1	T-bet	51497	30009	Gene	Gene	cells|nummod|START_ENTITY Role|nmod|cells Role|nmod|END_ENTITY	Role of T-bet in commitment of TH1 cells before IL-12-dependent selection .
15879017	0	TH1	36,39	TH2	63,66	TH1	TH2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	cytokines|nsubj|START_ENTITY cytokines|dobj|cytokines cytokines|nummod|END_ENTITY	Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro .
3160772	0	TH1	14,17	TH2	21,24	TH1	TH2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|dep|END_ENTITY	Analysis of a TH1 -- TH2 helper cell circuit .
15990796	0	TH2	63,66	CD4	86,89	TH2	CD4	15111(Tax:10090)	920	Gene	Gene	expression|nmod|START_ENTITY IFN-alpha|nmod|expression effects|nmod|IFN-alpha cytokines|nsubj|effects cytokines|nmod|cells cells|compound|END_ENTITY	Differential effects of IFN-alpha on the expression of various TH2 cytokines in human CD4 + T cells .
1972676	0	TH2	7,10	CD4	2,5	TH2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	line|compound|START_ENTITY line|compound|END_ENTITY	A CD4 + TH2 cell line isolated from mice chronically infected with Trypanosoma_cruzi induces IgG2 polyclonal response in vivo .
1976523	0	TH2	123,126	CD4	93,96	TH2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY different|nmod|cells different|nsubj|cells cells|compound|END_ENTITY	Resistance to murine cutaneous_leishmaniasis is mediated by TH1 cells , but disease-promoting CD4 + cells are different from TH2 cells .
15990796	0	TH2	63,66	IFN-alpha	24,33	TH2	IFN-alpha	15111(Tax:10090)	3439	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Differential effects of IFN-alpha on the expression of various TH2 cytokines in human CD4 + T cells .
12149469	0	TH2	3,6	IL-4	108,112	TH2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY has|nmod|cells has|dobj|series series|nmod|states states|acl|associated associated|nmod|probabilities probabilities|nmod|production production|compound|END_ENTITY	In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production .
8174178	0	TH2	34,37	IL-4	54,58	TH2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cytokines|compound|START_ENTITY release|nmod|cytokines Regulation|nmod|release Regulation|appos|END_ENTITY	Regulation of in vitro release of TH2 type cytokines -LRB- IL-4 , IL-6 -RRB- in the T cell response to the trinitrophenyl -LRB- TNP -RRB- hapten .
1978708	0	TH2	123,126	IL_5	49,53	TH2	IL 5	15111(Tax:10090)	16191(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Induction of antibody synthesis by CD4 + T cells : IL_5 is essential for induction of antigen-specific antibody responses by TH2 but not TH1 clones .
15879017	0	TH2	63,66	TH1	36,39	TH2	TH1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	cytokines|nummod|START_ENTITY cytokines|dobj|cytokines cytokines|nsubj|END_ENTITY	Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro .
3160772	0	TH2	21,24	TH1	14,17	TH2	TH1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of a TH1 -- TH2 helper cell circuit .
8586491	0	TH2	93,96	interleukin-10	55,69	TH2	interleukin-10	15111(Tax:10090)	16153(Tax:10090)	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	Effect of pharmacological agents on the productions of interleukin-10 by the murine D10.G4 .1 TH2 cell line in vitro .
22460072	0	TH2	107,110	protease-activated_receptor_2	66,95	TH2	protease-activated receptor 2	15111(Tax:10090)	14063(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY immunity|amod|END_ENTITY	Naive T cells sense the cysteine protease allergen papain through protease-activated_receptor_2 and propel TH2 immunity .
19833888	0	THADA	63,68	ADAMTS9	70,77	THADA	ADAMTS9	63892	56999	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D , THADA , ADAMTS9 , BCL11A , and MTNR1B affect different aspects of pancreatic beta-cell function .
19833888	0	THADA	63,68	BCL11A	79,85	THADA	BCL11A	63892	53335	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D , THADA , ADAMTS9 , BCL11A , and MTNR1B affect different aspects of pancreatic beta-cell function .
20211909	0	THAP1	0,5	DYT6	17,21	THAP1	DYT6	55145	55145	Gene	Gene	mutations|nummod|START_ENTITY mutations|appos|END_ENTITY	THAP1 mutations -LRB- DYT6 -RRB- are an additional cause of early-onset dystonia .
20200153	0	THAP1	29,34	HCF-1	63,68	THAP1	HCF-1	55145	3054	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc_transferase : a link between DYT6 and DYT3_dystonias .
22673507	0	THAP11	0,6	PCBP1	35,40	THAP11	PCBP1	57215	5093	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	THAP11 , a novel binding protein of PCBP1 , negatively regulates CD44 alternative splicing and cell invasion in a human hepatoma cell line .
26252500	0	THB1	0,4	nitrate_reductase	15,32	THB1	nitrate reductase	5724558(Tax:3055)	5722285(Tax:3055)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	THB1 regulates nitrate_reductase activity and THB1 and THB2 transcription differentially respond to NO and the nitrate/ammonium balance in Chlamydomonas .
25225421	0	THBD	64,68	Thrombomodulin	43,57	THBD	Thrombomodulin	7056	7056	Gene	Gene	START_ENTITY|nmod|Gene Gene|compound|END_ENTITY	Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene -LRB- THBD -RRB- Predict Mortality in Patients With Graft-Versus-Host_Disease .
26850833	0	THBS1	0,5	TGFB1	20,25	THBS1	TGFB1	21825(Tax:10090)	21803(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral_squamous_cell_carcinoma .
21526452	0	THBS1	43,48	thrombospondin	27,41	THBS1	thrombospondin	7057	7057	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of thrombospondin -LRB- THBS1 -RRB- in tumorigenic and nontumorigenic prostate epithelial cells in response to a chromatin-binding soy peptide .
9249061	0	THBS2	91,96	thrombospondin_2	68,84	THBS2	thrombospondin 2	7058	7058	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the promoter and transcription start sites of the human thrombospondin_2 gene -LRB- THBS2 -RRB- .
7558000	0	THBS3	63,68	thrombospondin_3	40,56	THBS3	thrombospondin 3	7059	7059	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and organization of the human thrombospondin_3 gene -LRB- THBS3 -RRB- .
6332883	0	THF	0,3	interleukin-2	32,45	THF	interleukin-2	21831(Tax:10090)	16183(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	THF , a thymic hormone , promotes interleukin-2 production in intact and thymus-deprived mice .
25726203	0	THIOREDOXIN_INTERACTING_PROTEIN	78,109	TXNIP	111,116	THIOREDOXIN INTERACTING PROTEIN	TXNIP	10628	10628	Gene	Gene	GENE|compound|START_ENTITY GENE|appos|END_ENTITY	GLYCEMIC CONTROL AND OXIDATIVE STRESS MARKERS AND THEIR RELATIONSHIP WITH THE THIOREDOXIN_INTERACTING_PROTEIN -LRB- TXNIP -RRB- GENE IN TYPE 2 DIABETIC PATIENTS .
17121535	0	THOX2	76,81	thyroid_oxidase_2	57,74	THOX2	thyroid oxidase 2	50506	50506	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Congenital_hypothyroidism caused by new mutations in the thyroid_oxidase_2 -LRB- THOX2 -RRB- gene .
7531049	0	THP	41,44	tamm-horsfall_protein	18,39	THP	tamm-horsfall protein	281567(Tax:9913)	281567(Tax:9913)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Bovine and rodent tamm-horsfall_protein -LRB- THP -RRB- genes : cloning , structural analysis , and promoter identification .
18427282	0	THP-1	65,70	ABCA1	22,27	THP-1	ABCA1	2736	19	Gene	Gene	macrophages|compound|START_ENTITY expression|nmod|macrophages expression|compound|END_ENTITY	Atorvastatin inhibits ABCA1 expression and cholesterol efflux in THP-1 macrophages by an LXR-dependent pathway .
19070858	0	THP-1	163,168	ABCA1	30,35	THP-1	ABCA1	2736	19	Gene	Gene	macrophage-derived|amod|START_ENTITY cells|amod|macrophage-derived pathway|nmod|cells kinase|dobj|pathway protein|dep|kinase protein|dep|reduces reduces|iobj|phosphorylation phosphorylation|nummod|END_ENTITY	Eicosapentaenoic_acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic_AMP / protein kinase A signaling pathway in THP-1 macrophage-derived foam cells .
20057170	0	THP-1	112,117	ABCA1	37,42	THP-1	ABCA1	2736	19	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells liver|xcomp|signaling liver|nsubj|expression expression|nmod|END_ENTITY	TGF-beta1 up-regulates expression of ABCA1 , ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells .
20625316	0	THP-1	67,72	ABCA1	24,29	THP-1	ABCA1	2736	19	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Contribution of D4-F to ABCA1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells .
21560346	0	THP-1	87,92	ABCA1	78,83	THP-1	ABCA1	2736	19	Gene	Gene	-RSB-|compound|START_ENTITY upgrades|nmod|-RSB- upgrades|dobj|expression expression|nmod|END_ENTITY	-LSB- Pravastatin and rosiglitazone combination therapy upgrades the expression of ABCA1 in THP-1 macrophages -RSB- .
22610793	0	THP-1	72,77	ABCA1	46,51	THP-1	ABCA1	2736	19	Gene	Gene	macrophages|compound|START_ENTITY expression|nmod|macrophages expression|nummod|END_ENTITY	S-Allylcysteine , a garlic compound , increases ABCA1 expression in human THP-1 macrophages .
23305686	0	THP-1	80,85	ABCA1	45,50	THP-1	ABCA1	2736	19	Gene	Gene	cells|compound|START_ENTITY methylation|nmod|cells methylation|nsubj|efflux efflux|nmod|DNA DNA|compound|END_ENTITY	Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells .
23564066	0	THP-1	94,99	ABCA1	45,50	THP-1	ABCA1	2736	19	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells LXRa|acl|signaling regulates|nmod|LXRa regulates|dobj|expression expression|nmod|END_ENTITY	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
25223800	0	THP-1	107,112	ABCA1	57,62	THP-1	ABCA1	2736	19	Gene	Gene	macrophages|compound|START_ENTITY pathway|nmod|macrophages repressing|nmod|pathway repressing|dobj|expression expression|compound|END_ENTITY	Urotensin_II increases foam cell formation by repressing ABCA1 expression through the ERK/NF-kB pathway in THP-1 macrophages .
25225013	0	THP-1	137,142	ABCA1	44,49	THP-1	ABCA1	2736	19	Gene	Gene	macrophages|compound|START_ENTITY signaling|nmod|macrophages alpha|acl|signaling receptor|nmod|alpha expression|nmod|receptor expression|nmod|END_ENTITY	Angiotensin - -LRB- 1-7 -RRB- upregulates expression of ABCA1 and ABCG1 through the Mas receptor via the liver X receptor alpha signaling pathway in THP-1 macrophages treated with Angiotensin_II .
25600616	0	THP-1	104,109	ABCA1	36,41	THP-1	ABCA1	2736	19	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells PPARy/LXRa|acl|signaling Propofol|nmod|PPARy/LXRa Propofol|dobj|expression expression|nmod|END_ENTITY	Propofol up-regulates expression of ABCA1 , ABCG1 , and SR-B1 through the PPARy/LXRa signaling pathway in THP-1 macrophage-derived foam cells .
26102194	0	THP-1	107,112	ABCA1	53,58	THP-1	ABCA1	2736	19	Gene	Gene	Cells|compound|START_ENTITY Signaling|nmod|Cells Enhanced|nmod|Signaling Enhanced|nmod|Expression Expression|compound|END_ENTITY	Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXRa Signaling in THP-1 Macrophage-Derived Foam Cells .
26261553	0	THP-1	98,103	ABCA1	20,25	THP-1	ABCA1	2736	19	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells LXRa|acl|signaling promotes|nmod|LXRa promotes|dobj|expression expression|compound|END_ENTITY	Lipoxin_A4 promotes ABCA1 expression and cholesterol efflux through the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
26729088	0	THP-1	51,56	ABCA1	31,36	THP-1	ABCA1	2736	19	Gene	Gene	Macrophages|compound|START_ENTITY Expression|nmod|Macrophages Expression|compound|END_ENTITY	Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages .
24422998	0	THP-1	140,145	AKT	53,56	THP-1	AKT	2736	207	Gene	Gene	line|compound|START_ENTITY plasma|nmod|line plasma|nsubj|END_ENTITY	Kaposi_sarcoma associated herpesvirus -LRB- KSHV -RRB- induces AKT hyperphosphorylation , bortezomib-resistance and GLUT-1 plasma membrane exposure in THP-1 monocytic cell line .
22190030	0	THP-1	81,86	APOB48	40,46	THP-1	APOB48	2736	338	Gene	Gene	monocytes|compound|START_ENTITY expression|nmod|monocytes expression|compound|END_ENTITY	Triglyceride-rich lipoprotein regulates APOB48 receptor gene expression in human THP-1 monocytes and macrophages .
26133317	0	THP-1	71,76	ATF3	0,4	THP-1	ATF3	2736	467	Gene	Gene	Formation|nmod|START_ENTITY Formation|compound|END_ENTITY	ATF3 Inhibits Tenascin-C-induced Foam Cell Formation in LPS-Stimulated THP-1 Macrophages by Suppressing TLR-4 .
16982432	0	THP-1	68,73	ATP-binding_cassette_A1	41,64	THP-1	ATP-binding cassette A1	2736	19	Gene	Gene	macrophages|compound|START_ENTITY END_ENTITY|nmod|macrophages	-LSB- Modulation of inflammatory cytokines by ATP-binding_cassette_A1 in THP-1 macrophages -RSB- .
14673498	0	THP-1	95,100	ATP_binding_cassette_transporter_A1	22,57	THP-1	ATP binding cassette transporter A1	2736	19	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Effects of oleate on ATP_binding_cassette_transporter_A1 expression and cholesterol efflux in THP-1 macrophage-derived foam cells -RSB- .
15202507	0	THP-1	106,111	ATP_binding_cassette_transporter_A1	32,67	THP-1	ATP binding cassette transporter A1	2736	19	Gene	Gene	macrophage-derived|amod|START_ENTITY cells|amod|macrophage-derived degradation|nmod|cells degradation|amod|END_ENTITY	Effect of apolipoprotein_A-I on ATP_binding_cassette_transporter_A1 degradation and cholesterol efflux in THP-1 macrophage-derived foam cells .
17689273	0	THP-1	118,123	ATP_binding_cassette_transporter_A1	47,82	THP-1	ATP binding cassette transporter A1	2736	19	Gene	Gene	macrophage-derived|amod|START_ENTITY cells|amod|macrophage-derived factor-alpha|nmod|cells inhibits|nmod|factor-alpha inhibits|dobj|down-regulation down-regulation|nmod|END_ENTITY	Interleukin-10 inhibits the down-regulation of ATP_binding_cassette_transporter_A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells .
24814410	0	THP-1	114,119	ATP_binding_cassette_transporter_A1	46,81	THP-1	ATP binding cassette transporter A1	2736	19	Gene	Gene	macrophages|compound|START_ENTITY mediated|nmod|macrophages expression|acl|mediated expression|amod|END_ENTITY	7-ketocholesteryl-9-carboxynonanoate enhances ATP_binding_cassette_transporter_A1 expression mediated by PPARy in THP-1 macrophages .
14732356	0	THP-1	87,92	Akt	35,38	THP-1	Akt	2736	207	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Simvastatin suppresses LPS-induced Akt phosphorylation in the human monocyte cell line THP-1 .
19915801	0	THP-1	49,54	Angiotensin_II	0,14	THP-1	Angiotensin II	2736	183	Gene	Gene	monocytes|compound|START_ENTITY expression|nmod|monocytes expression|compound|END_ENTITY	Angiotensin_II up-regulates CX3CR1 expression in THP-1 monocytes : impact on vascular_inflammation and atherogenesis .
12883330	0	THP-1	69,74	ApoC-I	35,41	THP-1	ApoC-I	2736	341	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Effect of atorvastatin on ApoE and ApoC-I synthesis and secretion by THP-1 macrophages .
21199725	0	THP-1	180,185	CCL2	136,140	THP-1	CCL2	2736	6347	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium_bovis bacillus Calmette Gu rin -LRB- BCG -RRB- - induced CCL2 secretion in human monocytic cell line THP-1 .
16306213	0	THP-1	48,53	CCR2	19,23	THP-1	CCR2	2736	729230	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of MCP1 , CCR2 , and iNOS expression in THP-1 macrophages by serum of children late after Kawasaki_disease .
18569070	0	THP-1	75,80	CD14	110,114	THP-1	CD14	2736	929	Gene	Gene	monocytes|compound|START_ENTITY monocytes|nmod|removal removal|nmod|END_ENTITY	Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14 .
19890360	0	THP-1	169,174	CD14	79,83	THP-1	CD14	2736	929	Gene	Gene	cell|compound|START_ENTITY beta-arrestin-2|nmod|cell line|amod|beta-arrestin-2 inhibits|nmod|line inhibits|dobj|END_ENTITY	Fenoterol , a beta -LRB- 2 -RRB- - adrenoceptor agonist , inhibits LPS-induced membrane-bound CD14 , TLR4/CD14 complex , and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line .
7681085	0	THP-1	53,58	CD14	45,49	THP-1	CD14	2736	929	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Cross-linking of lipopolysaccharide -LRB- LPS -RRB- to CD14 on THP-1 cells mediated by LPS-binding_protein .
9790819	0	THP-1	88,93	CD14	120,124	THP-1	CD14	2736	929	Gene	Gene	cells|compound|START_ENTITY activation|nmod|cells Antagonism|nmod|activation Antagonism|dep|role role|nmod|ligation ligation|compound|END_ENTITY	Antagonism by IL-4 and IL-10 of endotoxin-induced tissue factor activation in monocytic THP-1 cells : activating role of CD14 ligation .
25010893	0	THP-1	131,136	CD36	123,127	THP-1	CD36	2736	948	Gene	Gene	macrophages|compound|START_ENTITY END_ENTITY|nmod|macrophages	Kimchi methanol extract and the kimchi active compound , 3 ' - -LRB- 4 ' - hydroxyl-3 ' ,5 ' - dimethoxyphenyl -RRB- propionic_acid , downregulate CD36 in THP-1 macrophages stimulated by oxLDL .
12650676	0	THP-1	134,139	CD54	106,110	THP-1	CD54	2736	3383	Gene	Gene	line|amod|START_ENTITY using|nmod|line using|dobj|expression expression|nmod|molecules molecules|appos|END_ENTITY	Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules , CD54 and CD86 , on the naive THP-1 cell line .
17119987	0	THP-1	120,125	CD54	84,88	THP-1	CD54	2736	3383	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Prediction of preservative sensitization potential using surface marker CD86 and/or CD54 expression on human cell line , THP-1 .
21826143	0	THP-1	38,43	CD54	30,34	THP-1	CD54	2736	3383	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Biodegradable Polymers Induce CD54 on THP-1 Cells in Skin Sensitization Test .
12423654	0	THP-1	75,80	CD86	14,18	THP-1	CD86	2736	942	Gene	Gene	cells|compound|START_ENTITY internalization|nmod|cells internalization|nsubj|Evaluation Evaluation|nmod|expression expression|nummod|END_ENTITY	Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers .
21628959	0	THP-1	122,127	CD86	25,29	THP-1	CD86	2736	942	Gene	Gene	cells|compound|START_ENTITY allergen|nmod|cells stimulation|nmod|allergen protein|dobj|stimulation protein|nsubj|relationship relationship|nmod|END_ENTITY	The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells .
24136171	0	THP-1	79,84	CD86	43,47	THP-1	CD86	2736	942	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Role of PKC-b in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells .
19915801	0	THP-1	49,54	CX3CR1	28,34	THP-1	CX3CR1	2736	1524	Gene	Gene	monocytes|compound|START_ENTITY expression|nmod|monocytes expression|compound|END_ENTITY	Angiotensin_II up-regulates CX3CR1 expression in THP-1 monocytes : impact on vascular_inflammation and atherogenesis .
23407636	0	THP-1	118,123	CXCL8	52,57	THP-1	CXCL8	2736	3576	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Opposite effect of angiotensin receptor blockade on CXCL8 production and CXCR1/2 expression of angiotensin_II-treated THP-1 monocytes .
16781460	0	THP-1	72,77	Cathepsin_B	0,11	THP-1	Cathepsin B	2736	1508	Gene	Gene	monocyte/macrophages|compound|START_ENTITY nitroxyl|nmod|monocyte/macrophages target|nmod|nitroxyl target|nsubj|END_ENTITY	Cathepsin_B is a differentiation-resistant target for nitroxyl -LRB- HNO -RRB- in THP-1 monocyte/macrophages .
16926552	0	THP-1	72,77	ERK1/2	92,98	THP-1	ERK1/2	2736	5595;5594	Gene	Gene	monocytes|compound|START_ENTITY monocytes|nmod|END_ENTITY	Urokinase induces matrix_metalloproteinase-9 / gelatinase B expression in THP-1 monocytes via ERK1/2 and cytosolic phospholipase A2 activation and eicosanoid production .
7925881	0	THP-1	61,66	Fc_alpha-receptor	0,17	THP-1	Fc alpha-receptor	2736	2204	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Fc_alpha-receptor expression on the myelomonocytic cell line THP-1 : comparison with human alveolar macrophages .
8132624	0	THP-1	107,112	Fc_gamma_RII	81,93	THP-1	Fc gamma RII	2736	14130(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Physical and functional association of Src-related protein tyrosine kinases with Fc_gamma_RII in monocytic THP-1 cells .
11284739	0	THP-1	114,119	GTP_cyclohydrolase_I	0,20	THP-1	GTP cyclohydrolase I	2736	2643	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	GTP_cyclohydrolase_I mRNA : novel splice variants in the slime mould Physarum_polycephalum and in human monocytes -LRB- THP-1 -RRB- indicate conservation of mRNA processing .
21315065	0	THP-1	89,94	HO-1	49,53	THP-1	HO-1	2736	3162	Gene	Gene	monocytes|compound|START_ENTITY expression|nmod|monocytes expression|compound|END_ENTITY	Lipoic_acid ameliorates arsenic_trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages .
21769504	0	THP-1	47,52	Hsp60	32,37	THP-1	Hsp60	2736	3329	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Metformin induced expression of Hsp60 in human THP-1 monocyte cells .
12823280	0	THP-1	60,65	ICAM-1	17,23	THP-1	ICAM-1	2736	3383	Gene	Gene	monocytes|compound|START_ENTITY Up-regulation|nmod|monocytes Up-regulation|nmod|END_ENTITY	Up-regulation of ICAM-1 , CD11a/CD18 and CD11c/CD18 on human THP-1 monocytes stimulated by Streptococcus_suis serotype 2 .
9184693	0	THP-1	108,113	ICAM-1	61,67	THP-1	ICAM-1	2736	3383	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Beta_2-integrin-mediated signal up-regulates counterreceptor ICAM-1 expression on human monocytic cell line THP-1 through tyrosine phosphorylation .
3263853	0	THP-1	90,95	IL-1	32,36	THP-1	IL-1	2736	3553	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Post-transcriptional control of IL-1 gene expression in the acute_monocytic_leukemia line THP-1 .
24385987	0	THP-1	105,110	IL-1_b	84,90	THP-1	IL-1 b	2736	3553	Gene	Gene	Cells|compound|START_ENTITY Expression|nmod|Cells Expression|compound|END_ENTITY	Coculture with Late , but Not Early , Human Endothelial Progenitor Cells Up Regulates IL-1_b Expression in THP-1 Monocytic Cells in a Paracrine Manner .
24999366	0	THP-1	80,85	IL-1_b	40,46	THP-1	IL-1 b	2736	3553	Gene	Gene	Cells|compound|START_ENTITY Effects|nmod|Cells Effects|nmod|Decoction Decoction|nmod|END_ENTITY	Effects of Modified Simiao Decoction on IL-1_b and TNF_a Secretion in Monocytic THP-1 Cells with Monosodium_Urate Crystals-Induced Inflammation .
1710753	0	THP-1	70,75	IL-1_beta	52,61	THP-1	IL-1 beta	2736	3553	Gene	Gene	cells|compound|START_ENTITY mRNA|nmod|cells mRNA|compound|END_ENTITY	Platelet-activating factor stimulates expression of IL-1_beta mRNA in THP-1 cells .
18156187	0	THP-1	73,78	IL-1_receptor-associated_kinase-M	36,69	THP-1	IL-1 receptor-associated kinase-M	2736	11213	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Early and preferential induction of IL-1_receptor-associated_kinase-M in THP-1 cells by LPS derived from Porphyromonas_gingivalis .
21781483	0	THP-1	72,77	IL-1b	16,21	THP-1	IL-1b	2736	3553	Gene	Gene	-RSB-|compound|START_ENTITY transcription|nmod|-RSB- transcription|compound|END_ENTITY	-LSB- SIRT1 inhibits IL-1b mRNA transcription in lipopolysaccharide tolerant THP-1 cells -RSB- .
23328087	0	THP-1	61,66	IL-1b	48,53	THP-1	IL-1b	2736	3553	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	TET1 is a negative transcriptional regulator of IL-1b in the THP-1 cell line .
23760261	0	THP-1	142,147	IL-1b	79,84	THP-1	IL-1b	2736	3553	Gene	Gene	monocytes|compound|START_ENTITY stimulation|nmod|monocytes production|nmod|stimulation production|compound|END_ENTITY	Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1b production following Toll-like_receptor_2 stimulation in THP-1 monocytes .
25639477	0	THP-1	81,86	IL-1b	64,69	THP-1	IL-1b	2736	3553	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Vitamin_D3 Metabolites Enhance the NLRP3-Dependent Secretion of IL-1b from Human THP-1 Monocytic Cells .
27096899	0	THP-1	82,87	IL-1b	52,57	THP-1	IL-1b	2736	3553	Gene	Gene	Requirements|compound|START_ENTITY Induction|nmod|Requirements Induction|nmod|END_ENTITY	Lipopolysaccharide-Mediated Induction of Concurrent IL-1b and IL-23 Expression in THP-1 Cells Exhibits Differential Requirements for Caspase-1 and Cathepsin_B Activity .
23467650	0	THP-1	85,90	IL-23	12,17	THP-1	IL-23	2736	51561	Gene	Gene	monocytic|amod|START_ENTITY cells|amod|monocytic antigens|nmod|cells antigens|nsubj|Kinetics Kinetics|nmod|secretion secretion|amod|END_ENTITY	Kinetics of IL-23 and IL-12 secretion in response to Toxoplasma_gondii antigens from THP-1 monocytic cells .
26477825	0	THP-1	25,30	IL-23	108,113	THP-1	IL-23	2736	51561	Gene	Gene	derived|nmod|START_ENTITY Macrophages|acl|derived promote|nsubj|Macrophages promote|nmod|pathway pathway|compound|END_ENTITY	Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23 / IL-23R / b-catenin pathway .
26528819	0	THP-1	134,139	IL-23	98,103	THP-1	IL-23	2736	51561	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma_gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells .
26063187	0	THP-1	85,90	IL-6	19,23	THP-1	IL-6	2736	3569	Gene	Gene	Macrophages|compound|START_ENTITY Expression|nmod|Macrophages Expression|compound|END_ENTITY	Ox-LDL Upregulates IL-6 Expression by Enhancing NF-kB in an IGF2-Dependent Manner in THP-1 Macrophages .
10799807	0	THP-1	81,86	IL-8	15,19	THP-1	IL-8	2736	3576	Gene	Gene	Enhancement|amod|START_ENTITY Enhancement|nmod|production production|compound|END_ENTITY	Enhancement of IL-8 production from human monocytic and granulocytic cell lines , THP-1 and HL-60 , stimulated with Malassezia furfur .
17761353	0	THP-1	138,143	IL-8	24,28	THP-1	IL-8	2736	20309(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY factors|nmod|cells activation|nmod|factors promotes|nmod|activation promotes|dobj|expression expression|compound|END_ENTITY	Human placenta promotes IL-8 expression through activation of JNK/SAPK and transcription factors NF-kappaB and AP-1 in PMA-differentiated THP-1 cells .
19938227	0	THP-1	88,93	IL-8	57,61	THP-1	IL-8	2736	3576	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|compound|END_ENTITY	Anti-inflammatory effect of resveratrol by inhibition of IL-8 production in LPS-induced THP-1 cells .
21969073	0	THP-1	48,53	IL-8	24,28	THP-1	IL-8	2736	3576	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin .
9588080	0	THP-1	27,32	IL-8	15,19	THP-1	IL-8	2736	3576	Gene	Gene	monocyte|amod|START_ENTITY line|amod|monocyte END_ENTITY|nmod|line	-LSB- Production of IL-8 by the THP-1 monocyte cell line is regulated differently by cyclosporin and retinoic_acid -RSB- .
20309718	0	THP-1	137,142	IkappaBalpha	105,117	THP-1	IkappaBalpha	2736	4792	Gene	Gene	cells|compound|START_ENTITY phosphorylation|nmod|cells phosphorylation|compound|END_ENTITY	Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkappaBalpha phosphorylation in THP-1 cells .
11083779	0	THP-1	84,89	Interleukin-10	0,14	THP-1	Interleukin-10	2736	3586	Gene	Gene	cytokines|nmod|START_ENTITY cytokines|nsubj|modulates modulates|amod|END_ENTITY	Interleukin-10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia_burgdorferi lipoproteins .
17689273	0	THP-1	118,123	Interleukin-10	0,14	THP-1	Interleukin-10	2736	3586	Gene	Gene	macrophage-derived|amod|START_ENTITY cells|amod|macrophage-derived factor-alpha|nmod|cells inhibits|nmod|factor-alpha inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits the down-regulation of ATP_binding_cassette_transporter_A1 by tumour necrosis factor-alpha in THP-1 macrophage-derived foam cells .
15207247	0	THP-1	28,33	Interleukin-8	0,13	THP-1	Interleukin-8	2736	3576	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Interleukin-8 production by THP-1 cells stimulated by Salmonella_enterica_serovar_Typhimurium porins is mediated by AP-1 , NF-kappaB and MAPK pathways .
23711388	0	THP-1	93,98	JMJD3	49,54	THP-1	JMJD3	2736	23135	Gene	Gene	cells|appos|START_ENTITY END_ENTITY|nmod|cells	Proteomic changes induced by histone demethylase JMJD3 in TNF_alpha-treated human monocytic -LRB- THP-1 -RRB- cells .
26603571	0	THP-1	134,139	LACTB	125,130	THP-1	LACTB	2736	114294	Gene	Gene	macrophages|compound|START_ENTITY END_ENTITY|nmod|macrophages	MicroRNA-125b-5p attenuates lipopolysaccharide-induced monocyte_chemoattractant_protein-1 production by targeting inhibiting LACTB in THP-1 macrophages .
20871621	0	THP-1	73,78	LXRa	47,51	THP-1	LXRa	2736	10062	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Ibrolipim increases ABCA1/G1 expression by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
23564066	0	THP-1	94,99	LXRa	68,72	THP-1	LXRa	2736	10062	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
24751522	0	THP-1	84,89	LXRa	50,54	THP-1	LXRa	2736	10062	Gene	Gene	macrophages|compound|START_ENTITY END_ENTITY|nmod|macrophages	miR-613 regulates cholesterol efflux by targeting LXRa and ABCA1 in PPARy activated THP-1 macrophages .
26261553	0	THP-1	98,103	LXRa	72,76	THP-1	LXRa	2736	10062	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Lipoxin_A4 promotes ABCA1 expression and cholesterol efflux through the LXRa signaling pathway in THP-1 macrophage-derived foam cells .
2765502	0	THP-1	38,43	Lipoprotein_lipase	0,18	THP-1	Lipoprotein lipase	2736	4023	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Lipoprotein_lipase gene expression in THP-1 cells .
18490175	0	THP-1	113,118	MCP-1	72,77	THP-1	MCP-1	2736	6347	Gene	Gene	cells|compound|START_ENTITY increases|nmod|cells increases|dobj|expression expression|nmod|END_ENTITY	House dust mite , Dermatophagoides pteronissinus increases expression of MCP-1 , IL-6 , and IL-8 in human monocytic THP-1 cells .
21269946	0	THP-1	88,93	MIF	41,44	THP-1	MIF	2736	4282	Gene	Gene	macrophages|compound|START_ENTITY expression|nmod|macrophages expression|compound|END_ENTITY	Effect of asymmetric dimethylarginine on MIF expression and TNF-a and IL-8 secretion in THP-1 monocytes-derived macrophages .
25260616	0	THP-1	35,40	Notch_1	14,21	THP-1	Notch 1	2736	4851	Gene	Gene	cells|compound|START_ENTITY signaling|nmod|cells END_ENTITY|acl|signaling	Regulation of Notch_1 signaling in THP-1 cells enhances M2 macrophage differentiation .
24462857	0	THP-1	100,105	RACK-1	69,75	THP-1	RACK-1	2736	10399	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Corticosteroids modulate the expression of the PKC-anchoring protein RACK-1 and cytokine release in THP-1 cells .
12947334	0	THP-1	96,101	Rac	49,52	THP-1	Rac	2736	207	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Mevastatin suppresses lipopolysaccharide-induced Rac activation in the human monocyte cell line THP-1 .
21472666	0	THP-1	81,86	S100A8	54,60	THP-1	S100A8	2736	6279	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	RAGE-dependent regulation of calcium-binding proteins S100A8 and S100A9 in human THP-1 .
20863486	0	THP-1	94,99	TL1A	0,4	THP-1	TL1A	2736	9966	Gene	Gene	cells|compound|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	TL1A induces the expression of TGF-b-inducible gene h3 -LRB- big-h3 -RRB- through PKC , PI3K , and ERK in THP-1 cells .
21377791	0	THP-1	66,71	TNF-a	40,45	THP-1	TNF-a	2736	7124	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Ubiquitous hazardous metal lead induces TNF-a in human phagocytic THP-1 cells : primary role of ERK_1 / 2 .
21643507	0	THP-1	62,67	TNF-a	53,58	THP-1	TNF-a	2736	7124	Gene	Gene	Cells|compound|START_ENTITY Assays|nmod|Cells Assays|nmod|END_ENTITY	Two High Throughput Screen Assays for Measurement of TNF-a in THP-1 Cells .
22241121	0	THP-1	69,74	TNF-a	60,65	THP-1	TNF-a	2736	7124	Gene	Gene	cells|compound|START_ENTITY prevents|nmod|cells prevents|dobj|production production|nmod|END_ENTITY	High-density lipoprotein prevents SAA-induced production of TNF-a in THP-1 monocytic cells and peripheral blood mononuclear cells .
22410422	0	THP-1	108,113	TNF-a	78,83	THP-1	TNF-a	2736	7124	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Inhibitory effect of Astragalus_polysaccharides on lipopolysaccharide-induced TNF-a and IL-1b production in THP-1 cells .
23643167	0	THP-1	82,87	TNF-a	64,69	THP-1	TNF-a	2736	7124	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|nmod|END_ENTITY	-LSB- Effect of recombinant human growth_hormone on the secretion of TNF-a and IL-6 by THP-1 cells and its correlation with the NF-kB pathway -RSB- .
23769984	0	THP-1	48,53	TNF-a	14,19	THP-1	TNF-a	2736	7124	Gene	Gene	cells|compound|START_ENTITY Inhibition|nmod|cells Inhibition|nmod|production production|amod|END_ENTITY	Inhibition of TNF-a production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants .
26700004	0	THP-1	96,101	TNF-a	66,71	THP-1	TNF-a	2736	7124	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Human amnion mesenchymal cells inhibit lipopolysaccharide-induced TNF-a and IL-1b production in THP-1 cells .
25158571	0	THP-1	124,129	TNF-alpha	74,83	THP-1	TNF-alpha	2736	7124	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|amod|END_ENTITY	The influence of toll-like receptor -LRB- TLR - -RRB- agonists on lysozyme activity , TNF-alpha secretion and intercellular adhesion in THP-1 cells .
12617986	0	THP-1	29,34	Thrombomodulin	0,14	THP-1	Thrombomodulin	2736	7056	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Thrombomodulin expression by THP-1 but not by vascular endothelial cells is upregulated by pioglitazone .
25984739	0	THP-1	89,94	Toll-Like_Receptor_4	42,62	THP-1	Toll-Like Receptor 4	2736	7099	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	MiRNA-194 Regulates Palmitic_Acid-Induced Toll-Like_Receptor_4 Inflammatory Responses in THP-1 Cells .
21383675	0	THP-1	146,151	Toll-like_receptor_4	46,66	THP-1	Toll-like receptor 4	2736	7099	Gene	Gene	cells|compound|START_ENTITY interacts|nmod|cells interacts|nmod|secretion secretion|amod|END_ENTITY	Mannan-binding_lectin directly interacts with Toll-like_receptor_4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells .
21978170	0	THP-1	192,197	Toll-like_receptor_4	149,169	THP-1	Toll-like receptor 4	2736	7099	Gene	Gene	differentiation/activation|compound|START_ENTITY induction|nmod|differentiation/activation induction|amod|mediated mediated|amod|END_ENTITY	Branched a - -LRB- 1,4 -RRB- glucans from Lentinula edodes -LRB- L10 -RRB- in combination with radiation enhance cytotoxic effect on human lung_adenocarcinoma through the Toll-like_receptor_4 mediated induction of THP-1 differentiation/activation .
22015781	0	THP-1	63,68	Toll-like_receptor_4	0,20	THP-1	Toll-like receptor 4	2736	7099	Gene	Gene	macrophage|amod|START_ENTITY cells|amod|macrophage activation|nmod|cells up-regulated|nmod|activation formation|amod|up-regulated formation|nsubj|END_ENTITY	Toll-like_receptor_4 is up-regulated by mTOR activation during THP-1 macrophage foam cells formation .
8913279	0	THP-1	64,69	Tumor-associated_antigen_90K	0,28	THP-1	Tumor-associated antigen 90K	2736	3959	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Tumor-associated_antigen_90K activates myelomonocytic cell line THP-1 .
15876428	0	THP-1	131,136	VDR	108,111	THP-1	VDR	2736	7421	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	Lipopolysaccharide negatively modulates vitamin_D action by down-regulating expression of vitamin_D-induced VDR in human monocytic THP-1 cells .
11722647	0	THP-1	140,145	activator_protein-1	88,107	THP-1	activator protein-1	2736	3726	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Acholeplasma_laidlawii up-regulates granulysin gene expression via transcription factor activator_protein-1 in a human monocytic cell line , THP-1 .
8920996	0	THP-1	131,136	alpha_1-antitrypsin	21,40	THP-1	alpha 1-antitrypsin	2736	5265	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Divergent effects of alpha_1-antitrypsin on the regulation of iron metabolism in human erythroleukaemic -LRB- K562 -RRB- and myelomonocytic -LRB- THP-1 -RRB- cells .
9383708	0	THP-1	65,70	alpha_2-Macroglobulin	0,21	THP-1	alpha 2-Macroglobulin	2736	2	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	alpha_2-Macroglobulin synthesis by the human monocytic cell line THP-1 is differentiation state-dependent .
15090305	0	THP-1	88,93	androgen_receptor	41,58	THP-1	androgen receptor	2736	367	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Effect of testosterone on expression of androgen_receptor in human monocytic cell line THP-1 -RSB- .
19027716	0	THP-1	67,72	autotaxin	27,36	THP-1	autotaxin	2736	5168	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells .
19890360	0	THP-1	169,174	beta-arrestin-2	150,165	THP-1	beta-arrestin-2	2736	409	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Fenoterol , a beta -LRB- 2 -RRB- - adrenoceptor agonist , inhibits LPS-induced membrane-bound CD14 , TLR4/CD14 complex , and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line .
20473557	0	THP-1	76,81	calcium-sensing_receptor	29,53	THP-1	calcium-sensing receptor	2736	846	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|nmod|END_ENTITY	The functional expression of calcium-sensing_receptor in the differentiated THP-1 cells .
8872491	0	THP-1	87,92	cathepsin_B	52,63	THP-1	cathepsin B	2736	1508	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|compound|END_ENTITY	Gamma interferon induced increases in intracellular cathepsin_B activity in PMA primed THP-1 cells are blocked by inhibitors of protein_kinase_C .
9119982	0	THP-1	76,81	cathepsin_B	52,63	THP-1	cathepsin B	2736	1508	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|compound|END_ENTITY	Interferon-gamma induced increases in intracellular cathepsin_B activity in THP-1 cells are dependent on RNA transcription .
9130007	0	THP-1	66,71	cathepsin_B	42,53	THP-1	cathepsin B	2736	1508	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|compound|END_ENTITY	Endotoxin induces increased intracellular cathepsin_B activity in THP-1 cells .
9458327	0	THP-1	81,86	cathepsin_B	57,68	THP-1	cathepsin B	2736	1508	Gene	Gene	cells|compound|START_ENTITY activity|nmod|cells activity|amod|END_ENTITY	Effect of protein kinase modulators on the regulation of cathepsin_B activity in THP-1 human monocytic_leukemia cells .
9828078	0	THP-1	67,72	cathepsin_B	52,63	THP-1	cathepsin B	2736	1508	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Modulation of interferon gamma induced increases in cathepsin_B in THP-1 cells by adrenergic agonists and antagonists .
15314095	0	THP-1	51,56	caveolin-1	26,36	THP-1	caveolin-1	2736	857	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism .
10210777	0	THP-1	28,33	endothelial_cell_adhesion_molecules	43,78	THP-1	endothelial cell adhesion molecules	2736	6401	Gene	Gene	cells|compound|START_ENTITY cells|nmod|END_ENTITY	Adhesion of human monocytic THP-1 cells to endothelial_cell_adhesion_molecules or extracellular matrix proteins via beta1_integrins regulates heparin_binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- expression .
17093291	0	THP-1	52,57	endothelial_or_lipoprotein_lipase	15,48	THP-1	endothelial or lipoprotein lipase	2736	4023	Gene	Gene	macrophages|compound|START_ENTITY END_ENTITY|nmod|macrophages	Suppression of endothelial_or_lipoprotein_lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion .
8753812	0	THP-1	55,60	granulocyte_colony-stimulating_factor	14,51	THP-1	granulocyte colony-stimulating factor	2736	1440	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Production of granulocyte_colony-stimulating_factor by THP-1 cells in response to retinoic_acid and phorbol_ester is mediated through the autocrine production of interleukin-1 .
9367827	0	THP-1	138,143	granulocyte_colony-stimulating_factor	82,119	THP-1	granulocyte colony-stimulating factor	2736	1440	Gene	Gene	cells|compound|START_ENTITY stimulate|nmod|cells stimulate|dobj|production production|nmod|END_ENTITY	Dexamethasone and interleukin-1 potently synergize to stimulate the production of granulocyte_colony-stimulating_factor in differentiated THP-1 cells .
26806731	0	THP-1	105,110	high_mobility_protein_box-1	50,77	THP-1	high mobility protein box-1	2736	3146	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	-LSB- Role of nuclear factor of activated T cells-2 in high_mobility_protein_box-1 release in human monocytic THP-1 cells in vitro -RSB- .
1587306	0	THP-1	78,83	interferon-gamma	15,31	THP-1	interferon-gamma	2736	3458	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1 .
11895951	0	THP-1	66,71	interleukin-10	37,51	THP-1	interleukin-10	2736	3586	Gene	Gene	cells|compound|START_ENTITY production|nmod|cells production|amod|END_ENTITY	Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia_burgdorferi lipoproteins .
17485526	0	THP-1	72,77	interleukin-10	10,24	THP-1	interleukin-10	2736	3586	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Orf_virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes , but only partially impairs their proliferation .
25209104	0	THP-1	90,95	interleukin-10	122,136	THP-1	interleukin-10	2736	3586	Gene	Gene	macrophages|compound|START_ENTITY macrophages|nmod|production production|amod|END_ENTITY	Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production .
23777496	0	THP-1	110,115	interleukin-23	62,76	THP-1	interleukin-23	2736	27178	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Ciclosporin_A inhibits production of interleukin-12 / 23p40 and interleukin-23 by the human monocyte cell line , THP-1 .
8805854	0	THP-1	94,99	interleukin-2_receptor	14,36	THP-1	interleukin-2 receptor	2736	3559	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of interleukin-2_receptor gamma_chain mRNA expression in human monocytic cell line THP-1 .
10551153	0	THP-1	37,42	interleukin-8	9,22	THP-1	interleukin-8	2736	3576	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Enhanced interleukin-8 production in THP-1 human monocytic cells by lipopolysaccharide from oral microorganisms and granulocyte-macrophage_colony-stimulating_factor .
11591715	0	THP-1	49,54	interleukin-8	15,28	THP-1	interleukin-8	2736	3576	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein -LRB- a -RRB- .
11755918	0	THP-1	130,135	interleukin-8	16,29	THP-1	interleukin-8	2736	3576	Gene	Gene	macrophages|compound|START_ENTITY 14_prostaglandin_J2|nmod|macrophages metabolite|dobj|14_prostaglandin_J2 metabolite|nsubj|Upregulation Upregulation|nmod|expression expression|amod|END_ENTITY	Upregulation of interleukin-8 expression by prostaglandin_D2 metabolite 15-deoxy-delta12 , _ 14_prostaglandin_J2 -LRB- 15d-PGJ2 -RRB- in human THP-1 macrophages .
11914967	0	THP-1	107,112	interleukin-8	49,62	THP-1	interleukin-8	2736	3576	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1 .
9188651	0	THP-1	87,92	interleukin-8	166,179	THP-1	interleukin-8	2736	3576	Gene	Gene	line|appos|START_ENTITY induces|nmod|line induces|advcl|acting acting|nmod|sites sites|nmod|gene gene|amod|END_ENTITY	Human_cytomegalovirus induces interleukin-8 production by a human monocytic cell line , THP-1 , through acting concurrently on AP-1 - and NF-kappaB-binding sites of the interleukin-8 gene .
9188651	0	THP-1	87,92	interleukin-8	30,43	THP-1	interleukin-8	2736	3576	Gene	Gene	line|appos|START_ENTITY induces|nmod|line induces|dobj|production production|amod|END_ENTITY	Human_cytomegalovirus induces interleukin-8 production by a human monocytic cell line , THP-1 , through acting concurrently on AP-1 - and NF-kappaB-binding sites of the interleukin-8 gene .
8425605	0	THP-1	60,65	leukotriene_C4_synthase	33,56	THP-1	leukotriene C4 synthase	2736	4056	Gene	Gene	cell|compound|START_ENTITY END_ENTITY|nmod|cell	Photoaffinity labelling of human leukotriene_C4_synthase in THP-1 cell membranes .
23794138	0	THP-1	97,102	lipoprotein_lipase	33,51	THP-1	lipoprotein lipase	2736	4023	Gene	Gene	cell|compound|START_ENTITY cell|amod|END_ENTITY	Hydrolysis products generated by lipoprotein_lipase and endothelial_lipase differentially impact THP-1 macrophage cell signalling pathways .
25149060	0	THP-1	129,134	lipoprotein_lipase	96,114	THP-1	lipoprotein lipase	2736	4023	Gene	Gene	macrophages|compound|START_ENTITY targeting|nmod|macrophages targeting|dobj|gene gene|amod|END_ENTITY	MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein_lipase gene in human THP-1 macrophages .
10479651	0	THP-1	92,97	monocyte_chemoattractant_protein-1	28,62	THP-1	monocyte chemoattractant protein-1	2736	6347	Gene	Gene	cells|compound|START_ENTITY secretion|nmod|cells secretion|amod|END_ENTITY	9-cis retinoic_acid induces monocyte_chemoattractant_protein-1 secretion in human monocytic THP-1 cells .
14761478	0	THP-1	77,82	nuclear_factor-kappaB	52,73	THP-1	nuclear factor-kappaB	2736	4790	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	-LSB- The effect of silicon_dioxide on the activation of nuclear_factor-kappaB in THP-1 cells -RSB- .
18841476	0	THP-1	139,144	p53	132,135	THP-1	p53	2736	7157	Gene	Gene	macrophages|compound|START_ENTITY END_ENTITY|nmod|macrophages	Apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- and HIF-1alpha protein are essential factors for nitric_oxide-dependent accumulation of p53 in THP-1 human myeloid macrophages .
8955215	0	THP-1	135,140	phospholipase_D	61,76	THP-1	phospholipase D	2736	2822	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	Induction of the P2z/P2X7 nucleotide receptor and associated phospholipase_D activity by lipopolysaccharide and IFN-gamma in the human THP-1 monocytic cell line .
11311138	0	THP-1	112,117	proline-rich_tyrosine_kinase_2	78,108	THP-1	proline-rich tyrosine kinase 2	2736	2185	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Monocyte_chemoattractant_protein_1 causes differential signalling mediated by proline-rich_tyrosine_kinase_2 in THP-1 cells .
17287633	0	THP-1	147,152	thrombomodulin	114,128	THP-1	thrombomodulin	2736	7056	Gene	Gene	monocytic|amod|START_ENTITY line|amod|monocytic expression|nmod|line expression|compound|END_ENTITY	Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes : effect of serum on thrombomodulin expression in the THP-1 monocytic cell line .
17287633	0	THP-1	147,152	thrombomodulin	38,52	THP-1	thrombomodulin	2736	7056	Gene	Gene	monocytic|amod|START_ENTITY line|amod|monocytic expression|nmod|line serum|nmod|expression effect|nmod|serum down-regulates|dep|effect down-regulates|dep|expression expression|compound|END_ENTITY	Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes : effect of serum on thrombomodulin expression in the THP-1 monocytic cell line .
9594445	0	THP-1	106,111	thrombomodulin	54,68	THP-1	thrombomodulin	2736	7056	Gene	Gene	cell|compound|START_ENTITY expression|nmod|cell expression|compound|END_ENTITY	Differential effect of tumor_necrosis_factor-alpha on thrombomodulin gene expression by human monocytoid -LRB- THP-1 -RRB- cell versus endothelial cells .
2867824	0	THP-1	70,75	tissue_transglutaminase	14,37	THP-1	tissue transglutaminase	2736	7052	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Expression of tissue_transglutaminase in cultured monocytic_leukemia -LRB- THP-1 -RRB- cells during differentiation .
10100747	0	THP-1	93,98	tumor_necrosis_factor	9,30	THP-1	tumor necrosis factor	2736	7124	Gene	Gene	released|xcomp|START_ENTITY released|nsubj|inhibitor inhibitor|compound|END_ENTITY	A 63 kDa tumor_necrosis_factor inhibitor released from a human monocytic_leukemia cell line , THP-1 .
1894940	0	THP-1	53,58	tumor_necrosis_factor	26,47	THP-1	tumor necrosis factor	2736	7124	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Differences in release of tumor_necrosis_factor from THP-1 cells stimulated by filtrates of antibiotic-killed Escherichia_coli .
2228228	0	THP-1	99,104	tumor_necrosis_factor	51,72	THP-1	tumor necrosis factor	2736	7124	Gene	Gene	line|appos|START_ENTITY END_ENTITY|nmod|line	Mycoplasmas induce transcription and production of tumor_necrosis_factor in a monocytic cell line , THP-1 , by a protein kinase C-independent pathway .
7806621	0	THP-1	122,127	tumor_necrosis_factor	11,32	THP-1	tumor necrosis factor	2736	7124	Gene	Gene	-RSB-|compound|START_ENTITY expression|nmod|-RSB- _|dobj|expression _|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of tumor_necrosis_factor and interferon-gamma on platelet-derived growth factor -LRB- PDGF -RRB- _ A_and_B gene expression in THP-1 monocytic cells -RSB- .
8660816	0	THP-1	89,94	tumor_necrosis_factor	31,52	THP-1	tumor necrosis factor	2736	7124	Gene	Gene	cells|compound|START_ENTITY release|nmod|cells release|nsubj|regulation regulation|nmod|receptor receptor|compound|END_ENTITY	Prostaglandin-E2 regulation of tumor_necrosis_factor receptor release in human monocytic THP-1 cells .
11998373	0	THP-1	135,140	tumor_necrosis_factor_alpha	74,101	THP-1	tumor necrosis factor alpha	2736	7124	Gene	Gene	-RSB-|compound|START_ENTITY studies|nmod|-RSB- studies|nmod|influence influence|nmod|ochratoxin_A ochratoxin_A|nmod|production production|nmod|END_ENTITY	-LSB- In vitro studies into the influence of ochratoxin_A on the production of tumor_necrosis_factor_alpha by the human monocytic cell line THP-1 -RSB- .
21481849	0	THP-1	149,154	tumor_necrosis_factor_alpha	108,135	THP-1	tumor necrosis factor alpha	2736	7124	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	aVb3-integrin expression through ERK activation mediates cell attachment and is necessary for production of tumor_necrosis_factor_alpha in monocytic THP-1 cells stimulated by phorbol_myristate_acetate .
7703311	0	THP-1	114,119	tumor_necrosis_factor_alpha	37,64	THP-1	tumor necrosis factor alpha	2736	7124	Gene	Gene	cells|compound|START_ENTITY mRNA|nmod|cells mRNA|compound|END_ENTITY	Estrogen modulates the expression of tumor_necrosis_factor_alpha mRNA in phorbol_ester-stimulated human monocytic THP-1 cells .
7576814	0	THP-1	81,86	tumour_necrosis_factor	26,48	THP-1	tumour necrosis factor	2736	7124	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of alpha-human tumour_necrosis_factor -LRB- TNF-alpha -RRB- by human monocytes -LRB- THP-1 -RRB- exposed to 2-chloroethyl_ethyl_sulphide -LRB- H-MG -RRB- .
12957716	0	THP-1	85,90	vascular_endothelial_growth_factor	21,55	THP-1	vascular endothelial growth factor	2736	7422	Gene	Gene	macrophages|compound|START_ENTITY expression|nmod|macrophages expression|compound|END_ENTITY	Homocysteine induces vascular_endothelial_growth_factor expression in differentiated THP-1 macrophages .
26088451	0	THP1	43,47	IL-8	20,24	THP1	IL-8	2736	3576	Gene	Gene	cells|compound|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	Cancer cell-derived IL-8 induces monocytic THP1 cells to secrete IL-8 via the mitogen-activated protein kinase pathway .
21782857	0	THP1	48,52	PLTP	0,4	THP1	PLTP	2736	5360	Gene	Gene	cells|compound|START_ENTITY regulates|nmod|cells regulates|nsubj|END_ENTITY	PLTP regulates STAT3 and NFkB in differentiated THP1 cells and human monocyte-derived macrophages .
12803856	0	THP1	153,157	interferon-gamma_receptor_1	45,72	THP1	interferon-gamma receptor 1	2736	3459	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Antileishmanial drugs cause up-regulation of interferon-gamma_receptor_1 , not only in the monocytes of visceral_leishmaniasis cases but also in cultured THP1 cells .
7545622	0	THP_1	58,63	P450	50,54	THP 1	P450	2736	1555	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Expression and regulation of aromatase cytochrome P450 in THP_1 human myeloid_leukaemia cells .
22162340	0	THRAP1	54,60	MED13	47,52	THRAP1	MED13	9969	9969	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An 800 kb deletion at 17q23 .2 including the MED13 -LRB- THRAP1 -RRB- gene , revealed by aCGH in a patient with a SMC 17p .
23525231	0	THRAP3	0,6	HELZ2	22,27	THRAP3	HELZ2	230753(Tax:10090)	229003(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation .
19725132	0	THRB	147,151	thyroid_hormone_receptor_beta	116,145	THRB	thyroid hormone receptor beta	7068	7068	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Multiple genomic aberrations in a patient with mental_retardation and hypogonadism : 45 , X/46 , X , psu dic -LRB- Y -RRB- karyotype , thyroid_hormone_receptor_beta -LRB- THRB -RRB- mutation and heterozygosity for Wilson_disease .
23806029	0	THRB	62,66	thyroid_hormone_receptor_beta	31,60	THRB	thyroid hormone receptor beta	7068	7068	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Incidental identification of a thyroid_hormone_receptor_beta -LRB- THRB -RRB- gene variant in a family with autoimmune_thyroid_disease .
24371310	0	THRIL	23,28	TNFa	39,43	THRIL	TNFa	102659353	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The long noncoding RNA THRIL regulates TNFa expression through its interaction with hnRNPL .
11811657	0	THRP	80,84	thyroid_hormone-responsive_protein	44,78	THRP	thyroid hormone-responsive protein	286928(Tax:10116)	286928(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	mRNA differential display identification of thyroid_hormone-responsive_protein -LRB- THRP -RRB- gene in association with early phase of long-term potentiation .
12698219	0	THRP	46,50	thyroid_hormone_responsive_protein	10,44	THRP	thyroid hormone responsive protein	286928(Tax:10116)	286928(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of thyroid_hormone_responsive_protein -LRB- THRP -RRB- expression on PC12 cell survival .
9630690	0	THRP	59,63	thyroid_hormone_responsive_protein	23,57	THRP	thyroid hormone responsive protein	286928(Tax:10116)	286928(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Age-related changes in thyroid_hormone_responsive_protein -LRB- THRP -RRB- expression in cerebral tissue of rats .
17012164	0	THRSP	87,92	thyroid_hormone_responsive_spot_14	51,85	THRSP	thyroid hormone responsive spot 14	101800066	101800066	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Molecular cloning and expression of the duplicated thyroid_hormone_responsive_spot_14 -LRB- THRSP -RRB- genes in ducks .
19273419	0	THRSP	51,56	thyroid_hormone_responsive_spot_14	15,49	THRSP	thyroid hormone responsive spot 14	404755(Tax:9031)	404755(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Progresses on thyroid_hormone_responsive_spot_14 -LRB- THRSP -RRB- gene in chickens and ducks -RSB- .
26003825	0	THRb	22,26	BRAF	78,82	THRb	BRAF	7068	673	Gene	Gene	expression|nmod|START_ENTITY expression|dep|relationship relationship|nmod|expression expression|compound|END_ENTITY	Reduced expression of THRb in papillary_thyroid_carcinomas : relationship with BRAF mutation , aggressiveness and miR expression .
25302749	0	THRb	90,94	thyroid_hormone_receptor_beta	59,88	THRb	thyroid hormone receptor beta	7068	7068	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between promoter methylation and expression of thyroid_hormone_receptor_beta -LRB- THRb -RRB- gene in patients with gastric_cancer in an Iranian population .
22194418	0	THTR-1	25,31	Slc19a2	107,114	THTR-1	Slc19a2	116914(Tax:10090)	116914(Tax:10090)	Gene	Gene	contribution|nmod|START_ENTITY contribution|dep|END_ENTITY	Relative contribution of THTR-1 and THTR-2 in thiamin uptake by pancreatic acinar cells : studies utilizing Slc19a2 and Slc19a3 knockout mouse models .
21228213	0	THY1	13,17	THY1	138,142	THY1	THY1	21838(Tax:10090)	21838(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of THY1 and integrin_beta3 in cell adhesion during theca cell layer formation and the effect of follicle-stimulating hormone on THY1 and integrin_beta3 localization in mouse ovarian follicles .
21228213	0	THY1	138,142	THY1	13,17	THY1	THY1	21838(Tax:10090)	21838(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of THY1 and integrin_beta3 in cell adhesion during theca cell layer formation and the effect of follicle-stimulating hormone on THY1 and integrin_beta3 localization in mouse ovarian follicles .
18494145	0	THp-1	88,93	IL-8	45,49	THp-1	IL-8	2736	3576	Gene	Gene	cells|amod|START_ENTITY allergen|nmod|cells induced|nmod|allergen induced|nsubj|Role Role|nmod|MAPK MAPK|nmod|release release|nmod|END_ENTITY	Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naive THp-1 cells .
15469990	0	TI-VAMP	181,188	GLUT4	34,39	TI-VAMP	GLUT4	6845	6517	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Insulin and hypertonicity recruit GLUT4 to the plasma membrane of muscle cells by using N-ethylmaleimide-sensitive_factor-dependent SNARE mechanisms but different v-SNAREs : role of TI-VAMP .
17488725	0	TIA-1	52,57	T-cell_intracellular_antigen_1	20,50	TIA-1	T-cell intracellular antigen 1	7072	7072	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Two isoforms of the T-cell_intracellular_antigen_1 -LRB- TIA-1 -RRB- splicing factor display distinct splicing regulation activities .
17135269	0	TIA-1	63,68	TIAR	69,73	TIA-1	TIAR	7072	7073	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Fas-activated_serine / threonine_kinase -LRB- FAST_K -RRB- synergizes with TIA-1 / TIAR proteins to regulate Fas alternative splicing .
18768985	0	TIA-1	19,24	TIAR	25,29	TIA-1	TIAR	7072	7073	Gene	Gene	Mutation|nmod|START_ENTITY Mutation|parataxis|affects affects|nsubj|sites sites|amod|END_ENTITY	Mutation of mapped TIA-1 / TIAR binding sites in the 3 ' terminal stem-loop of West_Nile_virus minus-strand RNA in an infectious clone negatively affects genomic RNA amplification .
19339348	0	TIA-1	102,107	TIAR	108,112	TIA-1	TIAR	7072	7073	Gene	Gene	downstream|compound|START_ENTITY downstream|compound|END_ENTITY	Splicing of the large intron present in the nonstructural gene of minute_virus_of_mice is governed by TIA-1 / TIAR binding downstream of the nonconsensus donor .
23913578	0	TIA-1	15,20	TIAR	21,25	TIA-1	TIAR	7072	7073	Gene	Gene	TIAR-1|compound|START_ENTITY TIAR-1|compound|END_ENTITY	The C. _ elegans TIA-1 / TIAR homolog TIAR-1 is required to induce germ cell apoptosis .
12486009	0	TIA-1	23,28	U1-C	44,48	TIA-1	U1-C	7072	6631	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The splicing regulator TIA-1 interacts with U1-C to promote U1_snRNP recruitment to 5 ' splice sites .
12855701	0	TIA-1	132,137	cyclooxygenase-2	53,69	TIA-1	cyclooxygenase-2	7072	5743	Gene	Gene	TIAR|appos|START_ENTITY containing|dobj|TIAR complex|acl|containing recognized|nmod|complex recognized|nsubjpass|region region|nmod|END_ENTITY	The proximal region of the 3 ' - untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR , TIA-1 , TIAR , and the heterogeneous_nuclear_ribonucleoprotein_U .
12885872	0	TIA-1	72,77	cyclooxygenase-2	14,30	TIA-1	cyclooxygenase-2	7072	5743	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1 .
25461769	0	TIA1	0,4	annexin_A7	20,30	TIA1	annexin A7	21841(Tax:10090)	11750(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TIA1 interacts with annexin_A7 in regulating vascular endothelial cell autophagy .
12814935	0	TIAF1	0,5	beta1	53,58	TIAF1	beta1	9220	10678	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	TIAF1 participates in the transforming growth factor beta1 -- mediated growth regulation .
22570618	0	TIAM-1	28,34	CDC-42	45,51	TIAM-1	CDC-42	259373(Tax:6239)	174233(Tax:6239)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40 / DCC in neuronal protrusion and axon guidance .
17135269	0	TIAR	69,73	TIA-1	63,68	TIAR	TIA-1	7073	7072	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Fas-activated_serine / threonine_kinase -LRB- FAST_K -RRB- synergizes with TIA-1 / TIAR proteins to regulate Fas alternative splicing .
18768985	0	TIAR	25,29	TIA-1	19,24	TIAR	TIA-1	7073	7072	Gene	Gene	sites|amod|START_ENTITY affects|nsubj|sites Mutation|parataxis|affects Mutation|nmod|END_ENTITY	Mutation of mapped TIA-1 / TIAR binding sites in the 3 ' terminal stem-loop of West_Nile_virus minus-strand RNA in an infectious clone negatively affects genomic RNA amplification .
19339348	0	TIAR	108,112	TIA-1	102,107	TIAR	TIA-1	7073	7072	Gene	Gene	downstream|compound|START_ENTITY downstream|compound|END_ENTITY	Splicing of the large intron present in the nonstructural gene of minute_virus_of_mice is governed by TIA-1 / TIAR binding downstream of the nonconsensus donor .
23913578	0	TIAR	21,25	TIA-1	15,20	TIAR	TIA-1	7073	7072	Gene	Gene	TIAR-1|compound|START_ENTITY TIAR-1|compound|END_ENTITY	The C. _ elegans TIA-1 / TIAR homolog TIAR-1 is required to induce germ cell apoptosis .
22374443	0	TIARP	55,60	TNFa-induced_adipose-related_protein	17,53	TIARP	TNFa-induced adipose-related protein	79689	79689	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	-LSB- Crucial role of TNFa-induced_adipose-related_protein -LRB- TIARP -RRB- in the pathogenesis of autoimmune_arthritis -RSB- .
19795416	0	TICAM-1	13,20	BS69	62,66	TICAM-1	BS69	148022	10771	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Oligomerized TICAM-1 -LRB- TRIF -RRB- in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction .
22934250	0	TICAM-1	79,86	CD11c	104,109	TICAM-1	CD11c	106759(Tax:10090)	16411(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Cross-priming for antitumor CTL induced by soluble Ag + polyI : C depends on the TICAM-1 pathway in mouse CD11c -LRB- + -RRB- / CD8a -LRB- + -RRB- dendritic cells .
22585576	0	TIE2	61,65	Angiopoietin-2	0,14	TIE2	Angiopoietin-2	7010	285	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|nsubj|END_ENTITY	Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling .
25180601	0	TIE2	27,31	VE-PTP	10,16	TIE2	VE-PTP	21687(Tax:10090)	19263(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature .
15218362	0	TIEG	63,67	Smad7	70,75	TIEG	Smad7	7071	4092	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Differential gene expression of TGF_beta inducible early gene -LRB- TIEG -RRB- , Smad7 , Smad2 and Bard1 in normal and malignant breast tissue .
25338572	0	TIEG1	12,17	BAX	65,68	TIEG1	BAX	7071	581	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2 / BAX , PTEN -RSB- .
25338572	0	TIEG1	12,17	BCL-2	59,64	TIEG1	BCL-2	7071	596	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|BAX BAX|compound|END_ENTITY	-LSB- Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2 / BAX , PTEN -RSB- .
23815903	0	TIEG1	14,19	Bax	72,75	TIEG1	Bax	7071	581	Gene	Gene	Influence|nmod|START_ENTITY Influence|parataxis|-RSB- -RSB-|nsubj|END_ENTITY	-LSB- Influence of TIEG1 on apoptosis of HL-60 cells and expression of Bcl-2 / Bax -RSB- .
25867342	0	TIEG1	10,15	Bax	53,56	TIEG1	Bax	7071	581	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of TIEG1 on apoptosis and expression of Bcl-2 / Bax and Pten in leukemic cell lines .
25867342	0	TIEG1	10,15	Bcl-2	47,52	TIEG1	Bcl-2	7071	596	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of TIEG1 on apoptosis and expression of Bcl-2 / Bax and Pten in leukemic cell lines .
20070857	0	TIEG1	26,31	Bmal1	42,47	TIEG1	Bmal1	81813(Tax:10116)	29657(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork .
26801561	0	TIEG1	0,5	Osterix	15,22	TIEG1	Osterix	21847(Tax:10090)	170574(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	TIEG1 enhances Osterix expression and mediates its induction by TGFb and BMP2 in osteoblasts .
22011668	0	TIF-2	59,64	SRC-2	53,58	TIF-2	SRC-2	10499	10499	Gene	Gene	associated|nsubjpass|START_ENTITY expression|parataxis|associated expression|nmod|END_ENTITY	Sustained expression of steroid receptor coactivator SRC-2 / TIF-2 is associated with better prognosis in malignant_pleural_mesothelioma .
11265758	0	TIF-IA	0,6	Rrn3p	116,121	TIF-IA	Rrn3p	54700	853734(Tax:4932)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	TIF-IA , the factor mediating growth-dependent control of ribosomal RNA synthesis , is the mammalian homolog of yeast Rrn3p .
21163256	0	TIF1b	0,5	HP1	23,26	TIF1b	HP1	10155	23468	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	TIF1b association with HP1 is essential for post-gastrulation development , but not for Sertoli cell functions during spermatogenesis .
11711437	0	TIF1beta	0,8	C/EBPbeta	40,49	TIF1beta	C/EBPbeta	10155	1051	Gene	Gene	START_ENTITY|nmod|coactivator coactivator|nmod|END_ENTITY	TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937 .
9742105	0	TIF1beta	12,20	C/EBPbeta	57,66	TIF1beta	C/EBPbeta	10155	1051	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid_receptor to induce alpha1-acid glycoprotein gene expression .
15207724	0	TIF2	29,33	glucocorticoid_receptor	43,66	TIF2	glucocorticoid receptor	10499	2908	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Nuclear structure-associated TIF2 recruits glucocorticoid_receptor and its target DNA .
23132854	0	TIF2	48,52	glucocorticoid_receptor	103,126	TIF2	glucocorticoid receptor	10499	2908	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid_receptor is accompanied by conformational reorganizations .
12566447	0	TIFA	18,22	TRAF6	108,113	TIFA	TRAF6	92610	7189	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Identification of TIFA as an adapter protein that links tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- to interleukin-1 _ -LRB- IL-1 -RRB- _ receptor-associated_kinase-1 -LRB- IRAK-1 -RRB- in IL-1 receptor signaling .
19806788	0	TIG1	36,40	tazarotene-induced_gene_1	42,67	TIG1	tazarotene-induced gene 1	5918	5918	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Expression and mutation analysis of TIG1 -LRB- tazarotene-induced_gene_1 -RRB- in human gastric_cancer .
26247727	0	TIGAR	39,44	p53	0,3	TIGAR	p53	319801(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	p53 - and p73-independent activation of TIGAR expression in vivo .
26247727	0	TIGAR	39,44	p53	0,3	TIGAR	p53	319801(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	p53 - and p73-independent activation of TIGAR expression in vivo .
19940113	0	TILRR	0,5	IL-1RI	15,21	TILRR	IL-1RI	158326	3554	Gene	Gene	START_ENTITY|appos|co-receptor co-receptor|compound|END_ENTITY	TILRR , a novel IL-1RI co-receptor , potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB .
21984829	0	TIM	129,132	triose-phosphate_isomerase	101,127	TIM	triose-phosphate isomerase	3169211(Tax:300852)	3169211(Tax:300852)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	In vivo , in vitro , and x-ray crystallographic analyses suggest the involvement of an uncharacterized triose-phosphate_isomerase -LRB- TIM -RRB- barrel protein in protection against oxidative stress .
23137033	0	TIM-1	10,15	CD4	19,22	TIM-1	CD4	117216(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation .
15793576	0	TIM-1	24,29	TIM-4	0,5	TIM-1	TIM-4	7984	91937	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	TIM-4 is the ligand for TIM-1 , and the TIM-1-TIM-4 interaction regulates T cell proliferation .
25091272	0	TIM-3	15,20	BAT3	27,31	TIM-3	BAT3	84868	7917	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	A role for the TIM-3 / GAL-9 / BAT3 pathway in determining the clinical phenotype of multiple_sclerosis .
22039368	0	TIM-3	84,89	CCL1	18,22	TIM-3	CCL1	84868	6346	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of CCL1 as a Gene Differentially Expressed in CD4 T Cells Expressing TIM-3 .
19676072	0	TIM-3	0,5	CD4	38,41	TIM-3	CD4	84868	920	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	TIM-3 is expressed on activated human CD4 + T cells and regulates Th1 and Th17 cytokines .
22445722	0	TIM-3	73,78	CD4	47,50	TIM-3	CD4	84868	920	Gene	Gene	expressing|dobj|START_ENTITY T|dep|expressing T|nsubj|Down-regulation Down-regulation|nmod|production production|nmod|END_ENTITY	Down-regulation of interleukin-2 production by CD4 -LRB- + -RRB- T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription .
24689929	0	TIM-3	14,19	CD4	23,26	TIM-3	CD4	84868	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Expression of TIM-3 on CD4 + and CD8 + T cells in the peripheral blood and synovial fluid of rheumatoid_arthritis .
25676534	0	TIM-3	19,24	CD4	9,12	TIM-3	CD4	171285(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Negative CD4 + TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation .
25937557	0	TIM-3	0,5	CD4	105,108	TIM-3	CD4	84868	920	Gene	Gene	Genetic|compound|START_ENTITY Variations|nsubj|Genetic Variations|advcl|Interfering Interfering|nmod|Gamma Gamma|nmod|Cells Cells|compound|END_ENTITY	TIM-3 Genetic Variations Affect Susceptibility to Osteoarthritis by Interfering with Interferon Gamma in CD4 + T Cells .
26062425	0	TIM-3	18,23	CD4	27,30	TIM-3	CD4	84868	920	Gene	Gene	START_ENTITY|nmod|tumor tumor|compound|END_ENTITY	-LSB- Up-regulation of TIM-3 on CD4 -LRB- + -RRB- tumor infiltrating lymphocytes predicts poor prognosis in human non-small-cell lung_cancer -RSB- .
24520422	0	TIM-3	15,20	CD8	31,34	TIM-3	CD8	84868	925	Gene	Gene	Levels|nmod|START_ENTITY Levels|dep|effector effector|acl:relcl|distinguish distinguish|nsubj|cells cells|compound|END_ENTITY	Levels of CD56 + TIM-3 - effector CD8 T cells distinguish HIV natural virus suppressors from patients receiving antiretroviral therapy .
25886742	0	TIM-3	0,5	Gal-9	6,11	TIM-3	Gal-9	84868	3965	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|interaction interaction|compound|END_ENTITY	TIM-3 / Gal-9 interaction induces IFNy-dependent IDO1 expression in acute_myeloid_leukemia blast cells .
25886742	0	TIM-3	0,5	Gal-9	6,11	TIM-3	Gal-9	84868	3965	Gene	Gene	START_ENTITY|appos|induces induces|nsubj|interaction interaction|compound|END_ENTITY	TIM-3 / Gal-9 interaction induces IFNy-dependent IDO1 expression in acute_myeloid_leukemia blast cells .
26279267	0	TIM-3	2,7	Gal-9	8,13	TIM-3	Gal-9	84868	3965	Gene	Gene	START_ENTITY|parataxis|Autocrine Autocrine|nsubj|END_ENTITY	A TIM-3 / Gal-9 Autocrine Stimulatory Loop Drives Self-Renewal of Human Myeloid_Leukemia Stem Cells and Leukemic_Progression .
20463811	0	TIM-3	11,16	Galectin-9	0,10	TIM-3	Galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY regulates|nsubj|interaction END_ENTITY|parataxis|regulates	Galectin-9 / TIM-3 interaction regulates virus-specific primary and memory CD8 T cell response .
23936526	0	TIM-3	26,31	Galectin-9	15,25	TIM-3	Galectin-9	84868	3965	Gene	Gene	pathway|compound|START_ENTITY Involvement|dep|pathway Involvement|nmod|END_ENTITY	Involvement of Galectin-9 / TIM-3 pathway in the systemic inflammatory response in early-onset preeclampsia .
24477913	0	TIM-3	29,34	Galectin-9	0,10	TIM-3	Galectin-9	84868	3965	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing : an effect abrogated within the cystic_fibrosis_lung .
24253699	0	TIM-3	62,67	T_cell_immunoglobulin_domain_and_mucin-3	20,60	TIM-3	T cell immunoglobulin domain and mucin-3	84868	84868	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human T_cell_immunoglobulin_domain_and_mucin-3 -LRB- TIM-3 -RRB- on kidney tissue from systemic_lupus_erythematosus -LRB- SLE -RRB- patients .
23555261	0	TIM-3	0,5	galectin-9	37,47	TIM-3	galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	act|nsubj|START_ENTITY act|nmod|receptor receptor|nmod|END_ENTITY	TIM-3 does not act as a receptor for galectin-9 .
24651720	0	TIM-3	17,22	galectin-9	80,90	TIM-3	galectin-9	84868	3965	Gene	Gene	NK|compound|START_ENTITY NK|dep|TIM-3 TIM-3|dep|interaction interaction|amod|END_ENTITY	Peripheral blood TIM-3 positive NK and CD8 + T cells throughout pregnancy : TIM-3 / galectin-9 interaction and its possible role during pregnancy .
24651720	0	TIM-3	74,79	galectin-9	80,90	TIM-3	galectin-9	84868	3965	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	Peripheral blood TIM-3 positive NK and CD8 + T cells throughout pregnancy : TIM-3 / galectin-9 interaction and its possible role during pregnancy .
25784621	0	TIM-3	59,64	galectin-9	82,92	TIM-3	galectin-9	84868	3965	Gene	Gene	Participation_of_T_cell_immunoglobulin_and_mucin_domain-3|appos|START_ENTITY END_ENTITY|nsubj|Participation_of_T_cell_immunoglobulin_and_mucin_domain-3	Participation_of_T_cell_immunoglobulin_and_mucin_domain-3 -LRB- TIM-3 -RRB- and its ligand -LRB- galectin-9 -RRB- in the pathogenesis of active_generalized_vitiligo .
26278059	0	TIM-3	35,40	galectin-9	41,51	TIM-3	galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|pathway pathway|amod|END_ENTITY	Feto-maternal immune regulation by TIM-3 / galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy .
26278059	0	TIM-3	35,40	galectin-9	41,51	TIM-3	galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|pathway pathway|amod|END_ENTITY	Feto-maternal immune regulation by TIM-3 / galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy .
26493689	0	TIM-3	41,46	tumor	13,18	TIM-3	TIM-3	171285(Tax:10090)	171285(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Apoptosis of tumor infiltrating effector TIM-3 + CD8 + T cells in colon_cancer .
15793576	0	TIM-4	0,5	TIM-1	24,29	TIM-4	TIM-1	91937	7984	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	TIM-4 is the ligand for TIM-1 , and the TIM-1-TIM-4 interaction regulates T cell proliferation .
19996108	0	TIMELESS	10,18	CHK2	49,53	TIMELESS	CHK2	8914	11200	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control .
22879814	0	TIMELESS	18,26	clock	68,73	TIMELESS	clock	33571(Tax:7227)	38872(Tax:7227)	Gene	Gene	START_ENTITY|dobj|oscillations oscillations|nmod|END_ENTITY	CULLIN-3 controls TIMELESS oscillations in the Drosophila circadian clock .
19098071	0	TIMING_OF_CAB_EXPRESSION_1	73,99	TOC1	101,105	TIMING OF CAB EXPRESSION 1	TOC1	836259(Tax:3702)	836259(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A genetic study of the Arabidopsis circadian clock with reference to the TIMING_OF_CAB_EXPRESSION_1 -LRB- TOC1 -RRB- gene .
24993912	0	TIMP	17,21	MMP-9	11,16	TIMP	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|parataxis|associated	Low sputum MMP-9 / TIMP ratio is associated with airway narrowing in smokers with asthma .
21631912	0	TIMP	78,82	tissue_inhibitor_of_metalloproteinase	39,76	TIMP	tissue inhibitor of metalloproteinase	7076	7076	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A dual role for microglia in promoting tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- expression in glial cells in response to neuroinflammatory stimuli .
3894382	0	TIMP	62,66	tissue_inhibitor_of_metalloproteinases	22,60	TIMP	tissue inhibitor of metalloproteinases	7076	7076	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of tissue_inhibitor_of_metalloproteinases -LRB- TIMP -RRB- in human cells .
20210014	0	TIMP	52,56	tissue_inhibitors_of_metalloproteinases	11,50	TIMP	tissue inhibitors of metalloproteinases	7076	7076	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of tissue_inhibitors_of_metalloproteinases -LRB- TIMP -RRB- on course and prognosis of head_and_neck_squamous_cell_carcinoma -RSB- .
22305890	0	TIMP-1	130,136	AKT	95,98	TIMP-1	AKT	7076	207	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Atorvastatin sensitizes human non-small cell lung_carcinomas to carboplatin via suppression of AKT activation and upregulation of TIMP-1 .
12388255	0	TIMP-1	17,23	ANG_II	0,6	TIMP-1	ANG II	116510(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	ANG_II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo .
16107690	0	TIMP-1	126,132	Akt	30,33	TIMP-1	Akt	21857(Tax:10090)	11651(Tax:10090)	Gene	Gene	transactivation|compound|START_ENTITY competent|nmod|transactivation renders|xcomp|competent renders|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation .
22957045	0	TIMP-1	49,55	Akt	71,74	TIMP-1	Akt	7076	207	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Nitric_oxide synthase and breast_cancer : role of TIMP-1 in NO-mediated Akt activation .
8664344	0	TIMP-1	23,29	Angiotensin_II	0,14	TIMP-1	Angiotensin II	116510(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Angiotensin_II induces TIMP-1 production in rat heart endothelial cells .
26366732	0	TIMP-1	0,6	Bcl-2	76,81	TIMP-1	Bcl-2	7076	596	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|nmod|END_ENTITY	TIMP-1 Inhibits Apoptosis in Lung_Adenocarcinoma Cells via Interaction with Bcl-2 .
15288834	0	TIMP-1	21,27	CD-34_and_factor-8	29,47	TIMP-1	CD-34 and factor-8	7076	947	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of MMP-9 , TIMP-1 , CD-34_and_factor-8 as prognostic markers for squamous_cell_carcinoma_of_the_tongue .
19010442	0	TIMP-1	0,6	CD44	27,31	TIMP-1	CD44	7076	960	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	TIMP-1 binding to proMMP-9 / CD44 complex localized at the cell surface promotes erythroid cell survival .
24635319	0	TIMP-1	0,6	CD63	63,67	TIMP-1	CD63	7076	967	Gene	Gene	chemotaxis|compound|START_ENTITY stem|nsubj|chemotaxis stem|nmod|signalling signalling|compound|END_ENTITY	TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling .
26001794	0	TIMP-1	0,6	CD63	21,25	TIMP-1	CD63	21857(Tax:10090)	12512(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice .
12496489	0	TIMP-1	41,47	IL-10	6,11	TIMP-1	IL-10	7076	3586	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|signaling signaling|compound|END_ENTITY	IL-10 / IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate_tumor lines .
7593617	0	TIMP-1	48,54	IL-10	0,5	TIMP-1	IL-10	7076	3586	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes .
9561025	0	TIMP-1	94,100	IL-10	73,78	TIMP-1	IL-10	21857(Tax:10090)	16153(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
7615646	0	TIMP-1	71,77	Interleukin-1_beta	0,18	TIMP-1	Interleukin-1 beta	7076	3553	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Interleukin-1_beta induction of tissue inhibitor of metalloproteinase -LRB- TIMP-1 -RRB- is functionally antagonized by prostaglandin_E2 in human synovial fibroblasts .
12120711	0	TIMP-1	33,39	MMP-1	26,31	TIMP-1	MMP-1	116510(Tax:10116)	300339(Tax:10116)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Sequential expressions of MMP-1 , TIMP-1 , IL-6 , and COX-2 genes in induced periapical_lesions in rats .
17217211	0	TIMP-1	87,93	MMP-1	41,46	TIMP-1	MMP-1	7076	4312	Gene	Gene	matrix_metalloproteinases|dep|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-1 , MMP-2 and MMP-9 -RRB- and their inhibitors -LRB- TIMP-1 and TIMP-2 -RRB- in oral_submucous_fibrosis .
26058005	0	TIMP-1	116,122	MMP-1	78,83	TIMP-1	MMP-1	7076	4312	Gene	Gene	metalloproteinases|appos|START_ENTITY metalloproteinases|dep|END_ENTITY	In vitro effect of caffeic_acid_phenethyl_ester on matrix metalloproteinases -LRB- MMP-1 and MMP-9 -RRB- and their inhibitor -LRB- TIMP-1 -RRB- in lipopolysaccharide-activated human monocytes .
10769686	0	TIMP-1	120,126	MMP-2	67,72	TIMP-1	MMP-2	7076	4313	Gene	Gene	matrix-metalloproteinase-2|appos|START_ENTITY matrix-metalloproteinase-2|appos|END_ENTITY	Nafoxidine modulates the expression of matrix-metalloproteinase-2 -LRB- MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in endothelial cells .
10810401	0	TIMP-1	141,147	MMP-2	75,80	TIMP-1	MMP-2	7076	4313	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10995877	0	TIMP-1	86,92	MMP-2	41,46	TIMP-1	MMP-2	7076	4313	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
12460604	0	TIMP-1	77,83	MMP-2	14,19	TIMP-1	MMP-2	7076	4313	Gene	Gene	counterregulators|xcomp|START_ENTITY counterregulators|nsubj|Expression Expression|nmod|END_ENTITY	Expression of MMP-2 , MMP-9 , and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of Parkinson 's _ disease .
12890147	0	TIMP-1	31,37	MMP-2	13,18	TIMP-1	MMP-2	7076	4313	Gene	Gene	expression|compound|START_ENTITY Gelatinases|appos|expression Gelatinases|dep|END_ENTITY	Gelatinases -LRB- MMP-2 and MMP-9 -RRB- , TIMP-1 expression and the extent of neovascularization in aggressive_non-Hodgkin 's _ lymphomas .
16101153	0	TIMP-1	136,142	MMP-2	62,67	TIMP-1	MMP-2	7076	4313	Gene	Gene	matrix_metalloproteinases_2_and_7|appos|START_ENTITY matrix_metalloproteinases_2_and_7|appos|END_ENTITY	Quantitative estimation of matrix_metalloproteinases_2_and_7 -LRB- MMP-2 , MMP-7 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases_1_and_2 -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_carcinoma tissue samples .
16188099	0	TIMP-1	29,35	MMP-2	23,28	TIMP-1	MMP-2	7076	4313	Gene	Gene	imbalance|compound|START_ENTITY induced|nsubj|imbalance END_ENTITY|parataxis|induced	-LSB- AP-1 Decoy modulating MMP-2 / TIMP-1 imbalance induced by bleomycin-A5 in pulmonary fibroblasts -RSB- .
17217211	0	TIMP-1	87,93	MMP-2	48,53	TIMP-1	MMP-2	7076	4313	Gene	Gene	matrix_metalloproteinases|dep|START_ENTITY matrix_metalloproteinases|appos|MMP-1 MMP-1|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-1 , MMP-2 and MMP-9 -RRB- and their inhibitors -LRB- TIMP-1 and TIMP-2 -RRB- in oral_submucous_fibrosis .
17879211	0	TIMP-1	88,94	MMP-2	32,37	TIMP-1	MMP-2	7076	4313	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|MMP-9 MMP-9|dep|END_ENTITY	Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic_nephropathy .
18607832	0	TIMP-1	7,13	MMP-2	0,5	TIMP-1	MMP-2	7076	4313	Gene	Gene	E-cadherin|appos|START_ENTITY E-cadherin|compound|END_ENTITY	MMP-2 , TIMP-1 , E-cadherin , and beta-catenin expression in endometrial_serous_carcinoma compared with low-grade endometrial_endometrioid_carcinoma and proliferative endometrium .
19723139	0	TIMP-1	81,87	MMP-2	40,45	TIMP-1	MMP-2	7076	4313	Gene	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|Expression Expression|nmod|END_ENTITY	Expression of matrix metalloproteinases MMP-2 , MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic_adenomas .
19953348	0	TIMP-1	78,84	MMP-2	25,30	TIMP-1	MMP-2	7076	4313	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Serum metalloproteinases MMP-2 , MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in patients on hemodialysis .
20712241	0	TIMP-1	72,78	MMP-2	34,39	TIMP-1	MMP-2	7076	4313	Gene	Gene	inhibitors|xcomp|START_ENTITY inhibitors|nsubj|END_ENTITY	-LSB- Plasma matrix metalloproteinases MMP-2 and MMP-9 and tissue inhibitors TIMP-1 and TIMP-2 in children treated for acute_lymphoblastic_leukemia -RSB- .
20853628	0	TIMP-1	83,89	MMP-2	53,58	TIMP-1	MMP-2	7076	4313	Gene	Gene	metalloproteinases|appos|START_ENTITY metalloproteinases|appos|pro-MMP-1 pro-MMP-1|dep|END_ENTITY	-LSB- Evaluation of matrix metalloproteinases -LRB- pro-MMP-1 , MMP-2 ,8 -RRB- and their inhibitor -LRB- TIMP-1 -RRB- contents in patients with occupational_lung_diseases -RSB- .
22712465	0	TIMP-1	47,53	MMP-2	13,18	TIMP-1	MMP-2	7076	4313	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Imbalance of MMP-2 and MMP-9 expression versus TIMP-1 and TIMP-2 reflects increased invasiveness of human testicular germ cell tumours .
23029478	0	TIMP-1	17,23	MMP-2	44,49	TIMP-1	MMP-2	7076	4313	Gene	Gene	Up-regulation|nmod|START_ENTITY inhibits|nsubj|Up-regulation inhibits|dobj|activities activities|compound|END_ENTITY	Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular_carcinoma .
25380883	0	TIMP-1	87,93	MMP-2	45,50	TIMP-1	MMP-2	7076	4313	Gene	Gene	proteinase-1|appos|START_ENTITY inhibitor|nmod|proteinase-1 matrix_metalloproteinase-2|appos|inhibitor matrix_metalloproteinase-2|appos|END_ENTITY	Increased plasma matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- , tissue inhibitor of proteinase-1 -LRB- TIMP-1 -RRB- , TIMP-2 , and urine MMP-2 concentrations correlate with proteinuria in renal transplant recipients .
25441368	0	TIMP-1	77,83	MMP-2	41,46	TIMP-1	MMP-2	7076	4313	Gene	Gene	Matrix_Metalloproteinases|appos|START_ENTITY Matrix_Metalloproteinases|appos|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
25576870	0	TIMP-1	99,105	MMP-2	135,140	TIMP-1	MMP-2	21857(Tax:10090)	17390(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|activities activities|amod|END_ENTITY	Platelet-derived_growth_factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities .
26711243	0	TIMP-1	43,49	MMP-2	20,25	TIMP-1	MMP-2	7076	4313	Gene	Gene	START_ENTITY|nsubj|Decreases Decreases|nmod|END_ENTITY	Decreases in plasma MMP-2 / TIMP-2 and MMP-9 / TIMP-1 ratios in uremic patients during hemodialysis .
27034654	0	TIMP-1	89,95	MMP-2	42,47	TIMP-1	MMP-2	7076	4313	Gene	Gene	Matrix_Metalloproteinases|appos|START_ENTITY Matrix_Metalloproteinases|dep|END_ENTITY	Expressions of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-7 , and MMP-9 -RRB- and Their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Inflammatory_Bowel_Diseases .
9561025	0	TIMP-1	94,100	MMP-2	119,124	TIMP-1	MMP-2	21857(Tax:10090)	17390(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|expression expression|compound|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
10810401	0	TIMP-1	141,147	MMP-9	82,87	TIMP-1	MMP-9	7076	4318	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10919715	0	TIMP-1	185,191	MMP-9	132,137	TIMP-1	MMP-9	7076	4318	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY matrix_metalloproteinase-9|appos|END_ENTITY	Infiltrative capacity of T_leukemia cell lines : a distinct functional property coupled to expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- .
10995877	0	TIMP-1	86,92	MMP-9	48,53	TIMP-1	MMP-9	7076	4318	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
11118636	0	TIMP-1	0,6	MMP-9	7,12	TIMP-1	MMP-9	7076	4318	Gene	Gene	START_ENTITY|dep|imbalance imbalance|compound|END_ENTITY	TIMP-1 / MMP-9 imbalance in an EBV-immortalized B lymphocyte cellular model : evidence for TIMP-1 multifunctional properties .
11118636	0	TIMP-1	88,94	MMP-9	7,12	TIMP-1	MMP-9	7076	4318	Gene	Gene	properties|compound|START_ENTITY evidence|nmod|properties imbalance|dep|evidence imbalance|compound|END_ENTITY	TIMP-1 / MMP-9 imbalance in an EBV-immortalized B lymphocyte cellular model : evidence for TIMP-1 multifunctional properties .
11471571	0	TIMP-1	144,150	MMP-9	79,84	TIMP-1	MMP-9	7076	4318	Gene	Gene	tissue_inhibitor_of_metalloproteinase-1|appos|START_ENTITY tissue_inhibitor_of_metalloproteinase-1|amod|matrix_metalloproteinase-9 matrix_metalloproteinase-9|dep|END_ENTITY	All trans-retinoic_acid selectively down-regulates matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and up-regulates tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in human bronchoalveolar lavage cells .
12014920	0	TIMP-1	58,64	MMP-9	122,127	TIMP-1	MMP-9	100009047(Tax:9986)	100008993(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|parataxis|_ _|nsubj|imbalance imbalance|nmod|expression expression|nmod|END_ENTITY	Platelet-activating factor induces the gene expression of TIMP-1 , -2 , and PAI-1 : imbalance between the gene expression of MMP-9 and TIMP-1_and _ -2 .
12525717	0	TIMP-1	21,27	MMP-9	15,20	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	IFNbeta lowers MMP-9 / TIMP-1 ratio , which predicts new enhancing lesions in patients with SPMS .
12576963	0	TIMP-1	107,113	MMP-9	45,50	TIMP-1	MMP-9	7076	4318	Gene	Gene	Imbalance|dep|START_ENTITY Imbalance|nmod|metalloproteinases metalloproteinases|dep|END_ENTITY	Imbalance between matrix metalloproteinases -LRB- MMP-9 and MMP-2 -RRB- and tissue inhibitors of metalloproteinases -LRB- TIMP-1 and TIMP-2 -RRB- in acute_respiratory_distress_syndrome patients .
14569458	0	TIMP-1	18,24	MMP-9	35,40	TIMP-1	MMP-9	21857(Tax:10090)	17395(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Overexpression of TIMP-1 under the MMP-9 promoter interferes with wound healing in transgenic_mice .
14971882	0	TIMP-1	114,120	MMP-9	55,60	TIMP-1	MMP-9	7076	4318	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY matrix_metalloproteinase-9|appos|END_ENTITY	Determination of the serum matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_matrix_metalloproteinase-1 -LRB- TIMP-1 -RRB- in patients with either advanced small-cell lung_cancer or non-small-cell lung_cancer prior to treatment .
15015006	0	TIMP-1	123,129	MMP-9	66,71	TIMP-1	MMP-9	7076	4318	Gene	Gene	matrix_metalloproteinase-9|appos|START_ENTITY matrix_metalloproteinase-9|appos|END_ENTITY	Effect of interferon beta-1a on serum matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_matrix_metalloproteinase -LRB- TIMP-1 -RRB- in relapsing remitting multiple_sclerosis patients .
15291899	0	TIMP-1	42,48	MMP-9	35,40	TIMP-1	MMP-9	7076	4318	Gene	Gene	release|compound|START_ENTITY isolated|nsubj|release isolated|nmod|effects effects|nmod|flunisolide flunisolide|nmod|END_ENTITY	In vitro effects of flunisolide on MMP-9 , TIMP-1 , fibronectin , TGF-beta1 release and apoptosis in sputum cells freshly isolated from mild to moderate asthmatics .
15810979	0	TIMP-1	22,28	MMP-9	16,21	TIMP-1	MMP-9	21857(Tax:10090)	17395(Tax:10090)	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Upregulation of MMP-9 / TIMP-1 enzymatic system in eosinophilic_meningitis caused by Angiostrongylus_cantonensis .
16042227	0	TIMP-1	12,18	MMP-9	6,11	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratios|amod|START_ENTITY ratios|dep|END_ENTITY	Serum MMP-9 / TIMP-1 and MMP-2 / TIMP-2 ratios in multiple_sclerosis : relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment .
16257222	0	TIMP-1	94,100	MMP-9	88,93	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	In bacterial_meningitis cortical brain_damage is associated with changes in parenchymal MMP-9 / TIMP-1 ratio and increased collagen type IV degradation .
16374054	0	TIMP-1	72,78	MMP-9	79,84	TIMP-1	MMP-9	21857(Tax:10090)	17395(Tax:10090)	Gene	Gene	MMP-2|compound|START_ENTITY MMP-2|dep|TIMP-2 TIMP-2|amod|END_ENTITY	rd1 mouse retina shows imbalance in cellular distribution and levels of TIMP-1 / MMP-9 , TIMP-2 / MMP-2 and sulfated glycosaminoglycans .
16412833	0	TIMP-1	85,91	MMP-9	28,33	TIMP-1	MMP-9	7076	4318	Gene	Gene	Matrix_metalloproteinase-9|appos|START_ENTITY Matrix_metalloproteinase-9|appos|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinase -LRB- TIMP-1 -RRB- in patients with relapsing-remitting multiple_sclerosis treated with interferon beta .
16916326	0	TIMP-1	120,126	MMP-9	114,119	TIMP-1	MMP-9	21857(Tax:10090)	17395(Tax:10090)	Gene	Gene	balance|compound|START_ENTITY /|dobj|balance /|dep|END_ENTITY	Overexpression of nitric_oxide synthase by the endothelium attenuates bleomycin-induced lung_fibrosis and impairs MMP-9 / TIMP-1 balance .
17184595	0	TIMP-1	54,60	MMP-9	48,53	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Simvastatin could prevent increase of the serum MMP-9 / TIMP-1 ratio in acute ischaemic_stroke .
17251814	0	TIMP-1	90,96	MMP-9	34,39	TIMP-1	MMP-9	7076	4318	Gene	Gene	metalloproteinases|appos|START_ENTITY inhibitors|nmod|metalloproteinases inhibitors|nsubj|metalloproteinases metalloproteinases|appos|MMP-8 MMP-8|dep|END_ENTITY	Matrix metalloproteinases -LRB- MMP-8 , MMP-9 -RRB- and the tissue inhibitors of metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in patients with fungal_keratitis .
17879211	0	TIMP-1	88,94	MMP-9	42,47	TIMP-1	MMP-9	7076	4318	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic_nephropathy .
17976016	0	TIMP-1	25,31	MMP-9	7,12	TIMP-1	MMP-9	7076	4318	Gene	Gene	bound|nmod|START_ENTITY bound|nsubjpass|END_ENTITY	Latent MMP-9 is bound to TIMP-1 before secretion .
18850474	0	TIMP-1	99,105	MMP-9	42,47	TIMP-1	MMP-9	7076	4318	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|matrix_metalloproteinase-9 matrix_metalloproteinase-9|appos|END_ENTITY	Expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinase -LRB- TIMP-1 -RRB- in tissues with a diagnosis of childhood_lymphoma .
18945772	0	TIMP-1	54,60	MMP-9	48,53	TIMP-1	MMP-9	7076	17395(Tax:10090)	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	Infection with human_cytomegalovirus alters the MMP-9 / TIMP-1 balance in human macrophages .
19235898	0	TIMP-1	9,15	MMP-9	47,52	TIMP-1	MMP-9	7076	4318	Gene	Gene	release|compound|START_ENTITY accompanies|nsubj|release accompanies|dobj|secretion secretion|compound|END_ENTITY	Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment .
19353331	0	TIMP-1	52,58	MMP-9	23,28	TIMP-1	MMP-9	7076	4318	Gene	Gene	associated|nsubjpass|START_ENTITY expression|parataxis|associated expression|nmod|END_ENTITY	Abnormal expression of MMP-9 and imbalance of MMP-9 / TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol .
19353331	0	TIMP-1	52,58	MMP-9	46,51	TIMP-1	MMP-9	7076	4318	Gene	Gene	associated|nsubjpass|START_ENTITY expression|parataxis|associated expression|nmod|END_ENTITY	Abnormal expression of MMP-9 and imbalance of MMP-9 / TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol .
19608737	0	TIMP-1	44,50	MMP-9	11,16	TIMP-1	MMP-9	7076	4318	Gene	Gene	unencumbered|nmod|START_ENTITY proenzyme|amod|unencumbered proenzyme|compound|END_ENTITY	Neutrophil MMP-9 proenzyme , unencumbered by TIMP-1 , undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast_growth_factor -LRB- FGF-2 -RRB- / FGFR-2 pathway .
19728856	0	TIMP-1	129,135	MMP-9	69,74	TIMP-1	MMP-9	7076	4318	Gene	Gene	1|appos|START_ENTITY metalloproteinases|dobj|1 metalloproteinases|nsubj|serum serum|nmod|matrix_metalloproteinase_9 matrix_metalloproteinase_9|appos|END_ENTITY	Pre-treatment serum and plasma levels of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinases 1 -LRB- TIMP-1 -RRB- in gastric_cancer patients .
19847138	0	TIMP-1	60,66	MMP-9	19,24	TIMP-1	MMP-9	7076	4318	Gene	Gene	TIMP-2|compound|START_ENTITY inhibitors|dobj|TIMP-2 inhibitors|nsubj|END_ENTITY	Metalloproteinases MMP-9 , MMP-2 and their tissue inhibitors TIMP-1 , TIMP-2 in peripheral transbronchial lung biopsies of patients with sarcoidosis .
19889076	0	TIMP-1	52,58	MMP-9	40,45	TIMP-1	MMP-9	7076	4318	Gene	Gene	372|compound|START_ENTITY have|nsubj|372 polymorphisms|parataxis|have polymorphisms|nmod|END_ENTITY	Host single nucleotide polymorphisms of MMP-9 -1562 / TIMP-1 372 have gender differences in the risk of gastric_intestinal_metaplasia after Helicobacter_pylori_infection .
19927649	0	TIMP-1	39,45	MMP-9	33,38	TIMP-1	MMP-9	7076	4318	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of SiO2 on expression of MMP-9 / TIMP-1 in human alveolar macrophages in vitro -RSB- .
20030715	0	TIMP-1	6,12	MMP-9	0,5	TIMP-1	MMP-9	7076	4318	Gene	Gene	imbalance|compound|START_ENTITY induced|nsubj|imbalance END_ENTITY|appos|induced	MMP-9 / TIMP-1 imbalance induced in human dendritic cells by Porphyromonas_gingivalis .
20801641	0	TIMP-1	95,101	MMP-9	42,47	TIMP-1	MMP-9	7076	4318	Gene	Gene	matrix_metalloproteinase_9|appos|START_ENTITY matrix_metalloproteinase_9|appos|END_ENTITY	Expression of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- and tissue_inhibitor_of_metalloproteinases_1 -LRB- TIMP-1 -RRB- by colorectal_cancer cells and adjacent stroma cells -- associations with histopathology and patients outcome .
20840538	0	TIMP-1	120,126	MMP-9	114,119	TIMP-1	MMP-9	116510(Tax:10116)	81687(Tax:10116)	Gene	Gene	balance|compound|START_ENTITY balance|compound|END_ENTITY	KMUP-3 attenuates ventricular remodelling after myocardial_infarction through eNOS enhancement and restoration of MMP-9 / TIMP-1 balance .
20854798	0	TIMP-1	54,60	MMP-9	48,53	TIMP-1	MMP-9	116510(Tax:10116)	81687(Tax:10116)	Gene	Gene	system|compound|START_ENTITY modulation|dep|system modulation|nmod|END_ENTITY	Differential modulation of the cytokine-induced MMP-9 / TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin .
21963718	0	TIMP-1	64,70	MMP-9	58,63	TIMP-1	MMP-9	7076	4318	Gene	Gene	equilibrium|compound|START_ENTITY equilibrium|compound|END_ENTITY	Thioredoxin stimulates MMP-9 expression , de-regulates the MMP-9 / TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231_breast_cancer cells .
21993004	0	TIMP-1	27,33	MMP-9	21,26	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Tamoxifen lowers the MMP-9 / TIMP-1 ratio and inhibits the invasion capacity of ER-positive non-small cell lung_cancer cells .
22020222	0	TIMP-1	10,16	MMP-9	69,74	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY correlates|nsubj|ratio correlates|nmod|assessment assessment|nmod|activity activity|compound|END_ENTITY	Pro-MMP-9 / TIMP-1 ratio correlates poorly with a direct assessment of MMP-9 activity .
22139647	0	TIMP-1	28,34	MMP-9	0,5	TIMP-1	MMP-9	7076	4318	Gene	Gene	underexpression|compound|START_ENTITY due|nmod|underexpression overexpression|amod|due overexpression|compound|END_ENTITY	MMP-9 overexpression due to TIMP-1 and RECK underexpression is associated with prognosis in prostate_cancer .
22438979	0	TIMP-1	10,16	MMP-9	4,9	TIMP-1	MMP-9	21857(Tax:10090)	17395(Tax:10090)	Gene	Gene	axis|compound|START_ENTITY controls|nsubj|axis END_ENTITY|parataxis|controls	The MMP-9 / TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration .
23131422	0	TIMP-1	21,27	MMP-9	15,20	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Elevated serum MMP-9 / TIMP-1 ratio in patients with homozygous familial_hypercholesterolemia : effects of LDL-apheresis .
23792071	0	TIMP-1	48,54	MMP-9	25,30	TIMP-1	MMP-9	7076	4318	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	The circulating level of MMP-9 and its ratio to TIMP-1 as a predictor of severity in patients with community-acquired_pneumonia .
24330623	0	TIMP-1	27,33	MMP-9	21,26	TIMP-1	MMP-9	7076	4318	Gene	Gene	complex|compound|START_ENTITY levels|dep|complex levels|nmod|END_ENTITY	Plasma levels of the MMP-9 : TIMP-1 complex as prognostic biomarker in breast_cancer : a retrospective study .
24340960	0	TIMP-1	53,59	MMP-9	46,51	TIMP-1	MMP-9	7076	4318	Gene	Gene	MMP-2|dep|START_ENTITY MMP-2|dep|END_ENTITY	-LSB- Indices of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , TIMP-1 -RRB- with juvenile_arthritis in children -RSB- .
24727739	0	TIMP-1	63,69	MMP-9	70,75	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Association of sepsis-related mortality with early increase of TIMP-1 / MMP-9 ratio .
24727739	3	TIMP-1	491,497	MMP-9	498,503	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	2 -RRB- Is there an association between TIMP-1 / MMP-9 ratio and sepsis severity and mortality during such period ?
25330860	0	TIMP-1	86,92	MMP-9	80,85	TIMP-1	MMP-9	116510(Tax:10116)	81687(Tax:10116)	Gene	Gene	Balance|compound|START_ENTITY Balance|compound|END_ENTITY	Resveratrol Attenuates the Blood-Brain Barrier Dysfunction by Regulation of the MMP-9 / TIMP-1 Balance after Cerebral_Ischemia Reperfusion in Rats .
25441368	0	TIMP-1	77,83	MMP-9	48,53	TIMP-1	MMP-9	7076	4318	Gene	Gene	Matrix_Metalloproteinases|appos|START_ENTITY Matrix_Metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
26570691	0	TIMP-1	45,51	MMP-9	38,43	TIMP-1	MMP-9	7076	4318	Gene	Gene	MRPROANP|appos|START_ENTITY MRPROANP|compound|END_ENTITY	1030 : BIOMARKERS IN PEDIATRIC SEPSIS : MMP-9 , TIMP-1 , MRPROANP , AND ADIPOCYTE_FATTY-ACID_BINDING_PROTEIN .
26626455	0	TIMP-1	24,30	MMP-9	15,20	TIMP-1	MMP-9	7076	4318	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Association of MMP-9 to TIMP-1 ratio with long-term body weight and waist circumference after dietary weight reduction in men with metabolic_syndrome .
9300240	0	TIMP-1	104,110	MMP-9	52,57	TIMP-1	MMP-9	116510(Tax:10116)	81687(Tax:10116)	Gene	Gene	gelatinase_B|appos|START_ENTITY gelatinase_B|appos|END_ENTITY	Differential regulation of glomerular gelatinase_B -LRB- MMP-9 -RRB- and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in obese Zucker rats .
9561025	0	TIMP-1	94,100	MMP-9	125,130	TIMP-1	MMP-9	21857(Tax:10090)	17395(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|expression expression|compound|END_ENTITY	IL-10 inhibition of human prostate PC-3 ML cell metastases in SCID mice : IL-10 stimulation of TIMP-1 and inhibition of MMP-2 / MMP-9 expression .
12454321	0	TIMP-1	49,55	MMP9	12,16	TIMP-1	MMP9	7076	4318	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Circulating MMP9 , vitamin_D and variation in the TIMP-1 response with VDR genotype : mechanisms for inflammatory damage in chronic_disorders ?
10995877	0	TIMP-1	86,92	MT1-MMP	55,62	TIMP-1	MT1-MMP	7076	4323	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
22427646	0	TIMP-1	94,100	Matrix_metalloproteinase-10	0,27	TIMP-1	Matrix metalloproteinase-10	7076	4319	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Matrix_metalloproteinase-10 -LRB- MMP-10 -RRB- interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2 : binding studies and crystal structure .
25549087	0	TIMP-1	16,22	MiR-29a	0,7	TIMP-1	MiR-29a	7076	407021	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-b Activated Kinase 1 Binding Protein 1 , Implications for Systemic_Sclerosis .
21711826	0	TIMP-1	171,177	STAT3	162,167	TIMP-1	STAT3	21857(Tax:10090)	20848(Tax:10090)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Tissue_inhibitor_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- deficiency exacerbates carbon_tetrachloride-induced liver_injury and fibrosis in mice : involvement of hepatocyte STAT3 in TIMP-1 production .
21711826	0	TIMP-1	41,47	STAT3	162,167	TIMP-1	STAT3	21857(Tax:10090)	20848(Tax:10090)	Gene	Gene	deficiency|appos|START_ENTITY exacerbates|nsubj|deficiency exacerbates|parataxis|involvement involvement|nmod|END_ENTITY	Tissue_inhibitor_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- deficiency exacerbates carbon_tetrachloride-induced liver_injury and fibrosis in mice : involvement of hepatocyte STAT3 in TIMP-1 production .
11694645	0	TIMP-1	79,85	TIMP-2	87,93	TIMP-1	TIMP-2	7076	7077	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
16042227	0	TIMP-1	12,18	TIMP-2	29,35	TIMP-1	TIMP-2	7076	7077	Gene	Gene	ratios|amod|START_ENTITY ratios|compound|END_ENTITY	Serum MMP-9 / TIMP-1 and MMP-2 / TIMP-2 ratios in multiple_sclerosis : relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment .
16374054	0	TIMP-1	72,78	TIMP-2	86,92	TIMP-1	TIMP-2	21857(Tax:10090)	21858(Tax:10090)	Gene	Gene	MMP-2|compound|START_ENTITY MMP-2|dep|END_ENTITY	rd1 mouse retina shows imbalance in cellular distribution and levels of TIMP-1 / MMP-9 , TIMP-2 / MMP-2 and sulfated glycosaminoglycans .
25380883	0	TIMP-1	87,93	TIMP-2	96,102	TIMP-1	TIMP-2	7076	7077	Gene	Gene	proteinase-1|appos|START_ENTITY inhibitor|nmod|proteinase-1 matrix_metalloproteinase-2|appos|inhibitor END_ENTITY|nsubj|matrix_metalloproteinase-2	Increased plasma matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- , tissue inhibitor of proteinase-1 -LRB- TIMP-1 -RRB- , TIMP-2 , and urine MMP-2 concentrations correlate with proteinuria in renal transplant recipients .
26711243	0	TIMP-1	43,49	TIMP-2	26,32	TIMP-1	TIMP-2	7076	7077	Gene	Gene	START_ENTITY|nsubj|Decreases Decreases|dep|END_ENTITY	Decreases in plasma MMP-2 / TIMP-2 and MMP-9 / TIMP-1 ratios in uremic patients during hemodialysis .
9543631	0	TIMP-1	16,22	TIMP-2	24,30	TIMP-1	TIMP-2	7076	7077	Gene	Gene	gelatinase|amod|START_ENTITY gelatinase|amod|END_ENTITY	Localization of TIMP-1 , TIMP-2 , TIMP-3 , gelatinase A and gelatinase B in pathological human corneas .
9543631	0	TIMP-1	16,22	TIMP-3	32,38	TIMP-1	TIMP-3	7076	7078	Gene	Gene	gelatinase|amod|START_ENTITY gelatinase|amod|END_ENTITY	Localization of TIMP-1 , TIMP-2 , TIMP-3 , gelatinase A and gelatinase B in pathological human corneas .
10098765	0	TIMP-1	42,48	Tissue_inhibitor_of_metalloproteinases-1	0,40	TIMP-1	Tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- mRNA is elevated in advanced stages of thyroid_carcinoma .
25867313	0	TIMP-1	56,62	angiotensin_II	11,25	TIMP-1	angiotensin II	116510(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|intervention intervention|amod|END_ENTITY	Effects of angiotensin_II intervention on MMP-2 , MMP-9 , TIMP-1 , and collagen expression in rats with pulmonary_hypertension .
9598840	0	TIMP-1	54,60	elastin	71,78	TIMP-1	elastin	116510(Tax:10116)	25043(Tax:10116)	Gene	Gene	accumulation|compound|START_ENTITY accumulation|compound|END_ENTITY	Metalloproteinase blockade by local overexpression of TIMP-1 increases elastin accumulation in rat carotid artery intima .
11471571	0	TIMP-1	144,150	matrix_metalloproteinase-9	51,77	TIMP-1	matrix metalloproteinase-9	7076	4318	Gene	Gene	tissue_inhibitor_of_metalloproteinase-1|appos|START_ENTITY tissue_inhibitor_of_metalloproteinase-1|amod|END_ENTITY	All trans-retinoic_acid selectively down-regulates matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and up-regulates tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in human bronchoalveolar lavage cells .
16321449	0	TIMP-1	69,75	matrix_metalloproteinase-9	16,42	TIMP-1	matrix metalloproteinase-9	7076	4318	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of matrix_metalloproteinase-9 and its tissue inhibitor -LRB- TIMP-1 -RRB- in acute disseminated encephalomyelitis .
18850474	0	TIMP-1	99,105	matrix_metalloproteinase-9	14,40	TIMP-1	matrix metalloproteinase-9	7076	4318	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinase -LRB- TIMP-1 -RRB- in tissues with a diagnosis of childhood_lymphoma .
15240007	0	TIMP-1	88,94	oncostatin_M	98,110	TIMP-1	oncostatin M	21857(Tax:10090)	18413(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY required|nmod|regulation required|nmod|END_ENTITY	Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin_M in murine fibroblasts .
11694645	0	TIMP-1	79,85	p53	102,105	TIMP-1	p53	7076	7157	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
24174628	0	TIMP-1	87,93	proMMP-9	124,132	TIMP-1	proMMP-9	7076	17395(Tax:10090)	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	Angiogenic capacity of M1 - and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9 .
24283658	0	TIMP-1	64,70	tissue_inhibitor_of_MMP-1	37,62	TIMP-1	tissue inhibitor of MMP-1	7076	7076	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Matrix_metalloproteinase _ -LRB- MMP -RRB- -8 and tissue_inhibitor_of_MMP-1 -LRB- TIMP-1 -RRB- gene polymorphisms in generalized aggressive periodontitis : gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy .
14674693	0	TIMP-1	109,115	tissue_inhibitor_of_matrix_metalloproteinase-1	61,107	TIMP-1	tissue inhibitor of matrix metalloproteinase-1	282092(Tax:9913)	282092(Tax:9913)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Identification , purification and partial characterization of tissue_inhibitor_of_matrix_metalloproteinase-1 -LRB- TIMP-1 -RRB- in bovine pulmonary artery smooth muscle .
21731773	0	TIMP-1	77,83	tissue_inhibitor_of_metalloproteases-1	37,75	TIMP-1	tissue inhibitor of metalloproteases-1	7076	7076	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	Mechanism of heparin acceleration of tissue_inhibitor_of_metalloproteases-1 -LRB- TIMP-1 -RRB- degradation by the human neutrophil elastase .
22823240	0	TIMP-1	84,90	tissue_inhibitor_of_metalloproteinase	45,82	TIMP-1	tissue inhibitor of metalloproteinase	7076	7076	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Stromelysin -LRB- matrix metalloproteinase-3 -RRB- and tissue_inhibitor_of_metalloproteinase -LRB- TIMP-1 -RRB- mRNA expression in scleritis .
8808115	0	TIMP-1	64,70	tissue_inhibitor_of_metalloproteinase	25,62	TIMP-1	tissue inhibitor of metalloproteinase	116510(Tax:10116)	116510(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Glomerular expression of tissue_inhibitor_of_metalloproteinase -LRB- TIMP-1 -RRB- in normal and diabetic rats .
10222217	0	TIMP-1	139,145	tissue_inhibitor_of_metalloproteinase-1	98,137	TIMP-1	tissue inhibitor of metalloproteinase-1	100009047(Tax:9986)	100009047(Tax:9986)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The effects of hyaluronan on matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- , interleukin-1beta -LRB- IL-1beta -RRB- , and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- gene expression during the development of osteoarthritis .
11988491	0	TIMP-1	137,143	tissue_inhibitor_of_metalloproteinase-1	96,135	TIMP-1	tissue inhibitor of metalloproteinase-1	21857(Tax:10090)	21857(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- gene .
1330702	0	TIMP-1	54,60	tissue_inhibitor_of_metalloproteinase-1	13,52	TIMP-1	tissue inhibitor of metalloproteinase-1	7076	7076	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in human hepatoma cells -LRB- HepG2 -RRB- .
19485944	0	TIMP-1	75,81	tissue_inhibitor_of_metalloproteinase-1	34,73	TIMP-1	tissue inhibitor of metalloproteinase-1	7076	7076	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in invasive breast_carcinoma .
8879438	0	TIMP-1	54,60	tissue_inhibitor_of_metalloproteinase-1	13,52	TIMP-1	tissue inhibitor of metalloproteinase-1	100009047(Tax:9986)	100009047(Tax:9986)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in rabbit aortic neointima after selective de-endothelialization .
12515831	0	TIMP-1	68,74	tissue_inhibitor_of_metalloproteinase_1	27,66	TIMP-1	tissue inhibitor of metalloproteinase 1	7076	7076	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Protein engineering of the tissue_inhibitor_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- inhibitory domain .
10866818	0	TIMP-1	75,81	tissue_inhibitor_of_metalloproteinases-1	33,73	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mechanisms of induction of human tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- gene expression by all-trans_retinoic_acid in combination with basic_fibroblast_growth_factor .
14669077	0	TIMP-1	58,64	tissue_inhibitor_of_metalloproteinases-1	16,56	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in colorectal_cancer patients .
17160480	0	TIMP-1	73,79	tissue_inhibitor_of_metalloproteinases-1	31,71	TIMP-1	tissue inhibitor of metalloproteinases-1	116510(Tax:10116)	116510(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inhibitory effect of emodin on tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- expression in rat hepatic stellate cells .
24998777	0	TIMP-1	119,125	tissue_inhibitor_of_metalloproteinases-1	77,117	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Purification and characterization of bioactive his6-tagged recombinant human tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- protein expressed at high yields in mammalian cells .
7614380	0	TIMP-1	60,66	tissue_inhibitor_of_metalloproteinases-1	18,58	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of a tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in bladder_cancer patients .
8518299	0	TIMP-1	65,71	tissue_inhibitor_of_metalloproteinases-1	23,63	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Structural analysis of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- by tryptic peptide mapping .
8532127	0	TIMP-1	56,62	tissue_inhibitor_of_metalloproteinases-1	14,54	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- by human astrocytic_tumors .
8559663	0	TIMP-1	119,125	tissue_inhibitor_of_metalloproteinases-1	77,117	TIMP-1	tissue inhibitor of metalloproteinases-1	116510(Tax:10116)	116510(Tax:10116)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Identification of the interleukin-6 / oncostatin_M response element in the rat tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- promoter .
8608981	0	TIMP-1	69,75	tissue_inhibitor_of_metalloproteinases-1	27,67	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced RNA expression of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in human breast_cancer .
9547291	0	TIMP-1	80,86	tissue_inhibitor_of_metalloproteinases-1	38,78	TIMP-1	tissue inhibitor of metalloproteinases-1	7076	7076	Gene	Gene	accumulation|appos|START_ENTITY accumulation|nmod|END_ENTITY	Cell cycle-associated accumulation of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in the nuclei of human gingival fibroblasts .
15386409	0	TIMP-1	58,64	tissue_inhibitor_of_metalloproteinases_1	16,56	TIMP-1	tissue inhibitor of metalloproteinases 1	7076	7076	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of tissue_inhibitor_of_metalloproteinases_1 -LRB- TIMP-1 -RRB- in human colorectal_adenoma and adenocarcinoma .
9182725	0	TIMP-1	80,86	tissue_inhibitor_of_metalloproteinases_1	38,78	TIMP-1	tissue inhibitor of metalloproteinases 1	7076	7076	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional activity of the human tissue_inhibitor_of_metalloproteinases_1 -LRB- TIMP-1 -RRB- gene in fibroblasts involves elements in the promoter , exon 1 and intron 1 .
20164040	0	TIMP-1	56,62	tissue_inhibitors_of_metalloproteinase_1	14,54	TIMP-1	tissue inhibitors of metalloproteinase 1	7076	7076	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of tissue_inhibitors_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- in gastric_cancer tissue .
11694645	0	TIMP-1	79,85	uPA	74,77	TIMP-1	uPA	7076	5328	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
9379846	0	TIMP-2	22,28	CNTF	0,4	TIMP-2	CNTF	7077	1270	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|compound|END_ENTITY	CNTF up-regulation of TIMP-2 in neuroblastoma cells .
10579795	0	TIMP-2	131,137	MMP-2	72,77	TIMP-2	MMP-2	7077	4313	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|mRNA mRNA|nmod|matrix_metalloproteinase-2 matrix_metalloproteinase-2|appos|END_ENTITY	Localization and quantification of mRNA for matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and tissue inhibitor of matrix_metalloproteinase-2 -LRB- TIMP-2 -RRB- in human benign and malignant prostatic tissue .
10810401	0	TIMP-2	149,155	MMP-2	75,80	TIMP-2	MMP-2	7077	4313	Gene	Gene	TIMP-1|dep|START_ENTITY matrix_metalloproteinases|appos|TIMP-1 matrix_metalloproteinases|appos|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10995877	0	TIMP-2	94,100	MMP-2	41,46	TIMP-2	MMP-2	7077	4313	Gene	Gene	TIMP-1|dep|START_ENTITY matrix_metalloproteinases|appos|TIMP-1 matrix_metalloproteinases|appos|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
11373158	0	TIMP-2	97,103	MMP-2	27,32	TIMP-2	MMP-2	282093(Tax:9913)	282872(Tax:9913)	Gene	Gene	metalloproteinases|appos|START_ENTITY metalloproteinases|dep|END_ENTITY	Matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- and tissue_inhibitor-2_of_matrix_metalloproteinases -LRB- TIMP-2 -RRB- in the placenta and interplacental uterine wall in normal cows and in cattle with retention of fetal membranes .
11565199	0	TIMP-2	60,66	MMP-2	34,39	TIMP-2	MMP-2	7077	4313	Gene	Gene	gelatinase|appos|START_ENTITY gelatinase|appos|END_ENTITY	A role for the 72 kDa gelatinase -LRB- MMP-2 -RRB- and its inhibitor -LRB- TIMP-2 -RRB- in human parturition , premature_rupture_of_membranes and intraamniotic_infection .
11802202	0	TIMP-2	23,29	MMP-2	17,22	TIMP-2	MMP-2	7077	4313	Gene	Gene	imbalance|compound|START_ENTITY role|dep|imbalance role|nmod|END_ENTITY	Clinical role of MMP-2 / TIMP-2 imbalance in hepatocellular_carcinoma .
11928819	0	TIMP-2	84,90	MMP-2	39,44	TIMP-2	MMP-2	29543(Tax:10116)	81686(Tax:10116)	Gene	Gene	matrix_metalloproteases|appos|START_ENTITY matrix_metalloproteases|appos|END_ENTITY	Expression of matrix_metalloproteases -LRB- MMP-2 , MT1 _ - MMP -RRB- and their tissue inhibitor -LRB- TIMP-2 -RRB- by rat sertoli cells in culture : implications for spermatogenesis .
12439941	0	TIMP-2	58,64	MMP-2	14,19	TIMP-2	MMP-2	7077	4313	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of MMP-2 , TIMP-2 protein and the ratio of MMP-2 / TIMP-2 in gallbladder_carcinoma and their significance .
12439941	0	TIMP-2	58,64	MMP-2	52,57	TIMP-2	MMP-2	7077	4313	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of MMP-2 , TIMP-2 protein and the ratio of MMP-2 / TIMP-2 in gallbladder_carcinoma and their significance .
12602913	0	TIMP-2	64,70	MMP-2	0,5	TIMP-2	MMP-2	7077	4313	Gene	Gene	phenotype|compound|START_ENTITY protein|dep|phenotype protein|compound|END_ENTITY	MMP-2 protein in invasive breast_cancer and the impact of MMP-2 / TIMP-2 phenotype on overall survival .
12755684	0	TIMP-2	0,6	MMP-2	59,64	TIMP-2	MMP-2	7077	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	TIMP-2 -LRB- tissue_inhibitor_of_metalloproteinase-2 -RRB- regulates MMP-2 -LRB- matrix_metalloproteinase-2 -RRB- activity in the extracellular environment after pro-MMP-2 activation by MT1 _ -LRB- membrane_type_1 -RRB- - MMP .
12801521	0	TIMP-2	174,180	MMP-2	157,162	TIMP-2	MMP-2	7077	4313	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|END_ENTITY	Epigallocatechin-3-gallate binding to MMP-2 inhibits gelatinolytic activity without influencing the attachment to extracellular matrix proteins but enhances MMP-2 binding to TIMP-2 .
15374620	0	TIMP-2	30,36	MMP-2	13,18	TIMP-2	MMP-2	282093(Tax:9913)	282872(Tax:9913)	Gene	Gene	complex|compound|START_ENTITY Isolation|dep|complex Isolation|nmod|END_ENTITY	Isolation of MMP-2 from MMP-2 / TIMP-2 complex : characterization of the complex and the free enzyme in pulmonary vascular smooth muscle plasma membrane .
15374620	0	TIMP-2	30,36	MMP-2	24,29	TIMP-2	MMP-2	282093(Tax:9913)	282872(Tax:9913)	Gene	Gene	complex|compound|START_ENTITY Isolation|dep|complex Isolation|nmod|END_ENTITY	Isolation of MMP-2 from MMP-2 / TIMP-2 complex : characterization of the complex and the free enzyme in pulmonary vascular smooth muscle plasma membrane .
15451196	0	TIMP-2	119,125	MMP-2	67,72	TIMP-2	MMP-2	102178107	102184364	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|MT1-MMP MT1-MMP|dep|END_ENTITY	Expression and localization of matrix_metalloproteinases -LRB- MT1-MMP , MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- during synepitheliochorial placentation of goats -LRB- Capra_hircus -RRB- .
15982804	0	TIMP-2	82,88	MMP-2	7,12	TIMP-2	MMP-2	7077	4313	Gene	Gene	factors|dep|START_ENTITY corrected|ccomp|factors corrected|nsubj|END_ENTITY	Tissue MMP-2 and MMP-9 -LSB- corrected -RSB- are better prognostic factors than serum MMP-2 / TIMP-2 -- complex or TIMP-1 -LSB- corrected -RSB- in stage -LSB- corrected -RSB- I-III lung_carcinoma .
15982804	0	TIMP-2	82,88	MMP-2	76,81	TIMP-2	MMP-2	7077	4313	Gene	Gene	factors|dep|START_ENTITY factors|nmod|END_ENTITY	Tissue MMP-2 and MMP-9 -LSB- corrected -RSB- are better prognostic factors than serum MMP-2 / TIMP-2 -- complex or TIMP-1 -LSB- corrected -RSB- in stage -LSB- corrected -RSB- I-III lung_carcinoma .
16101153	0	TIMP-2	144,150	MMP-2	62,67	TIMP-2	MMP-2	7077	4313	Gene	Gene	TIMP-1|dep|START_ENTITY matrix_metalloproteinases_2_and_7|appos|TIMP-1 matrix_metalloproteinases_2_and_7|appos|END_ENTITY	Quantitative estimation of matrix_metalloproteinases_2_and_7 -LRB- MMP-2 , MMP-7 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases_1_and_2 -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_carcinoma tissue samples .
16289164	0	TIMP-2	26,32	MMP-2	19,24	TIMP-2	MMP-2	374178(Tax:9031)	386583(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Changes in scleral MMP-2 , TIMP-2 and TGFbeta-2 mRNA expression after imposed myopic and hyperopic defocus in chickens .
17154296	0	TIMP-2	147,153	MMP-2	80,85	TIMP-2	MMP-2	282093(Tax:9913)	282872(Tax:9913)	Gene	Gene	tissue_inhibitor-2_of_matrix_metalloproteinases|dep|START_ENTITY expression|amod|tissue_inhibitor-2_of_matrix_metalloproteinases expression|dep|END_ENTITY	Quantitative analysis of messenger RNA expression of matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- , tissue_inhibitor-2_of_matrix_metalloproteinases -LRB- TIMP-2 -RRB- , and steroidogenic enzymes in bovine placentomes during gestation and postpartum .
17355922	0	TIMP-2	7,13	MMP-2	1,6	TIMP-2	MMP-2	7077	4313	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	-LSB- MMP-2 / TIMP-2 expression in the trophoblasts of patients with gestational_trophoblastic_disease -RSB- .
17374529	0	TIMP-2	47,53	MMP-2	117,122	TIMP-2	MMP-2	7077	4313	Gene	Gene	tissue_inhibitor_of_metalloproteinase-2|dep|START_ENTITY Serum|xcomp|tissue_inhibitor_of_metalloproteinase-2 Serum|nmod|inhibitor inhibitor|appos|END_ENTITY	Serum tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- and matrix_metalloproteinase-2 in complex with the inhibitor -LRB- MMP-2 : TIMP-2 -RRB- as prognostic markers in bladder_cancer .
17466450	0	TIMP-2	121,127	MMP-2	83,88	TIMP-2	MMP-2	7077	4313	Gene	Gene	metalloproteinases|appos|START_ENTITY metalloproteinases|dep|END_ENTITY	Noninvasive diagnosis of bladder_cancer by detection of matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- and their inhibitor -LRB- TIMP-2 -RRB- in urine .
17642161	0	TIMP-2	27,33	MMP-2	20,25	TIMP-2	MMP-2	7077	4313	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|nm23 nm23|appos|END_ENTITY	Expression of nm23 , MMP-2 , TIMP-2 in breast_neoplasm in Zhengzhou Center Hospital , China .
17982970	0	TIMP-2	19,25	MMP-2	13,18	TIMP-2	MMP-2	29543(Tax:10116)	81686(Tax:10116)	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	The roles of MMP-2 / TIMP-2 in extracellular matrix remodelling in the hearts of STZ-induced diabetic rats .
18651826	0	TIMP-2	94,100	MMP-2	42,47	TIMP-2	MMP-2	7077	4313	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY matrix_metalloproteinase_2|appos|END_ENTITY	Expression of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinase_2 -LRB- TIMP-2 -RRB- in medullary_thyroid_carcinoma : prognostic implications .
19391484	0	TIMP-2	132,138	MMP-2	74,79	TIMP-2	MMP-2	7077	4313	Gene	Gene	immunoexpression|appos|START_ENTITY immunoexpression|nmod|metalloproteinases metalloproteinases|amod|END_ENTITY	Aberrant tubulointerstitial immunoexpression of matrix metalloproteinases MMP-2 , MMP-9 and tissue_inhibitor_of_matrix_proteinase-2 -LRB- TIMP-2 -RRB- in acute cellular rejection of human renal allograft .
20137537	0	TIMP-2	123,129	MMP-2	83,88	TIMP-2	MMP-2	29543(Tax:10116)	81686(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY Effects|appos|mRNA Effects|appos|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	-LSB- Effects of losartan and simvastatin on collagen content , myocardial expression of MMP-2 mRNA , MMP-9 mRNA and TIMP-1 mRNA , TIMP-2 mRNA in pressure overload rat hearts -RSB- .
21526499	0	TIMP-2	102,108	MMP-2	69,74	TIMP-2	MMP-2	7077	4313	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY matrix_metalloproteinase_2|appos|END_ENTITY	Clinical significance of serum levels of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and its tissue inhibitor -LRB- TIMP-2 -RRB- in gastric_cancer .
21839835	0	TIMP-2	87,93	MMP-2	155,160	TIMP-2	MMP-2	7077	4313	Gene	Gene	tissue_inhibitor_of_matrix_metalloproteinases-2|appos|START_ENTITY domain|nmod|tissue_inhibitor_of_matrix_metalloproteinases-2 Peptide|nmod|domain inhibits|nsubj|Peptide inhibits|dobj|activation activation|nmod|matrix_metalloproteinase-2 matrix_metalloproteinase-2|appos|END_ENTITY	Peptide from the C-terminal domain of tissue_inhibitor_of_matrix_metalloproteinases-2 -LRB- TIMP-2 -RRB- inhibits membrane activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- .
22429332	0	TIMP-2	25,31	MMP-2	19,24	TIMP-2	MMP-2	7077	4313	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Irradiation alters MMP-2 / TIMP-2 system and collagen type IV degradation in brain .
22545131	0	TIMP-2	0,6	MMP-2	128,133	TIMP-2	MMP-2	7077	4313	Gene	Gene	protein|compound|START_ENTITY potentiates|nsubj|protein potentiates|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	TIMP-2 fusion protein with human serum albumin potentiates anti-angiogenesis-mediated inhibition of tumor growth by suppressing MMP-2 expression .
22621753	0	TIMP-2	97,103	MMP-2	41,46	TIMP-2	MMP-2	7077	4313	Gene	Gene	matrix_metalloproteinase|appos|START_ENTITY matrix_metalloproteinase|appos|END_ENTITY	Higher risk of matrix_metalloproteinase -LRB- MMP-2 , 7 , 9 -RRB- and tissue_inhibitor_of_metalloproteinase -LRB- TIMP-2 -RRB- genetic variants to gallbladder_cancer .
23398532	0	TIMP-2	0,6	MMP-2	24,29	TIMP-2	MMP-2	21858(Tax:10090)	17390(Tax:10090)	Gene	Gene	mutant|compound|START_ENTITY decreases|nsubj|mutant decreases|dobj|activity activity|compound|END_ENTITY	TIMP-2 mutant decreases MMP-2 activity and augments pressure overload induced LV_dysfunction and heart_failure .
24384769	0	TIMP-2	65,71	MMP-2	28,33	TIMP-2	MMP-2	7077	4313	Gene	Gene	2|appos|START_ENTITY inhibitor|dobj|2 inhibitor|nsubj|Matrix_metalloproteinase_2 Matrix_metalloproteinase_2|appos|END_ENTITY	Matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and their tissue inhibitor 2 -LRB- TIMP-2 -RRB- in gastric_cancer patients .
24395652	0	TIMP-2	119,125	MMP-2	66,71	TIMP-2	MMP-2	7077	4313	Gene	Gene	matrix_metalloproteinase_2|appos|START_ENTITY matrix_metalloproteinase_2|appos|END_ENTITY	Serum levels and tissue expression of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinases_2 -LRB- TIMP-2 -RRB- in colorectal_cancer patients .
24899319	0	TIMP-2	97,103	MMP-2	43,48	TIMP-2	MMP-2	7077	4313	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of matrix_metalloproteinases-2 -LRB- MMP-2 -RRB- and tissue inhibitors of metalloproteinases-2 -LRB- TIMP-2 -RRB- in oral_submucous_fibrosis and their correlation with disease severity .
25380883	0	TIMP-2	96,102	MMP-2	45,50	TIMP-2	MMP-2	7077	4313	Gene	Gene	START_ENTITY|nsubj|matrix_metalloproteinase-2 matrix_metalloproteinase-2|appos|END_ENTITY	Increased plasma matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- , tissue inhibitor of proteinase-1 -LRB- TIMP-1 -RRB- , TIMP-2 , and urine MMP-2 concentrations correlate with proteinuria in renal transplant recipients .
25412957	0	TIMP-2	35,41	MMP-2	29,34	TIMP-2	MMP-2	7077	4313	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Stoichiometric expression of MMP-2 / TIMP-2 in benign and malignant_tumours of the salivary gland .
25441368	0	TIMP-2	85,91	MMP-2	41,46	TIMP-2	MMP-2	7077	4313	Gene	Gene	TIMP-1|dep|START_ENTITY Matrix_Metalloproteinases|appos|TIMP-1 Matrix_Metalloproteinases|appos|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
26395636	0	TIMP-2	102,108	MMP-2	58,63	TIMP-2	MMP-2	374178(Tax:9031)	386583(Tax:9031)	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Expression and localization of matrix_metalloproteinases -LRB- MMP-2 , _ -7 , _ -9 -RRB- and their tissue inhibitors -LRB- TIMP-2 , -3 -RRB- in the chicken oviduct during maturation .
26711243	0	TIMP-2	26,32	MMP-2	20,25	TIMP-2	MMP-2	7077	4313	Gene	Gene	Decreases|dep|START_ENTITY Decreases|nmod|END_ENTITY	Decreases in plasma MMP-2 / TIMP-2 and MMP-9 / TIMP-1 ratios in uremic patients during hemodialysis .
27034654	0	TIMP-2	97,103	MMP-2	42,47	TIMP-2	MMP-2	7077	4313	Gene	Gene	TIMP-1|dep|START_ENTITY Matrix_Metalloproteinases|appos|TIMP-1 Matrix_Metalloproteinases|dep|END_ENTITY	Expressions of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-7 , and MMP-9 -RRB- and Their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Inflammatory_Bowel_Diseases .
8861023	0	TIMP-2	0,6	MMP-2	40,45	TIMP-2	MMP-2	7077	4313	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|binding binding|nmod|END_ENTITY	TIMP-2 mediates cell surface binding of MMP-2 .
10810401	0	TIMP-2	149,155	MMP-9	82,87	TIMP-2	MMP-9	7077	4318	Gene	Gene	TIMP-1|dep|START_ENTITY matrix_metalloproteinases|appos|TIMP-1 matrix_metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Limited value of preoperative serum analyses of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and tissue_inhibitors_of_matrix_metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in colorectal_cancer .
10995877	0	TIMP-2	94,100	MMP-9	48,53	TIMP-2	MMP-9	7077	4318	Gene	Gene	TIMP-1|dep|START_ENTITY matrix_metalloproteinases|appos|TIMP-1 matrix_metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
16042227	0	TIMP-2	29,35	MMP-9	6,11	TIMP-2	MMP-9	7077	4318	Gene	Gene	ratios|compound|START_ENTITY ratios|dep|END_ENTITY	Serum MMP-9 / TIMP-1 and MMP-2 / TIMP-2 ratios in multiple_sclerosis : relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment .
17251814	0	TIMP-2	98,104	MMP-9	34,39	TIMP-2	MMP-9	7077	4318	Gene	Gene	TIMP-1|dep|START_ENTITY metalloproteinases|appos|TIMP-1 inhibitors|nmod|metalloproteinases inhibitors|nsubj|metalloproteinases metalloproteinases|appos|MMP-8 MMP-8|dep|END_ENTITY	Matrix metalloproteinases -LRB- MMP-8 , MMP-9 -RRB- and the tissue inhibitors of metalloproteinases -LRB- TIMP-1 , TIMP-2 -RRB- in patients with fungal_keratitis .
19141395	0	TIMP-2	57,63	MMP-9	32,37	TIMP-2	MMP-9	7077	4318	Gene	Gene	expression|compound|START_ENTITY analysis|appos|expression analysis|nmod|END_ENTITY	Immunohistochemical analysis of MMP-9 , MMP-2 and TIMP-1 , TIMP-2 expression in the central nervous system following infection with viral and bacterial_meningitis .
19317417	0	TIMP-2	15,21	MMP-9	9,14	TIMP-2	MMP-9	7077	4318	Gene	Gene	up-regulation|compound|START_ENTITY END_ENTITY|dep|up-regulation	Vascular MMP-9 / TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke : a combined laser microdissection and protein array study .
19847138	0	TIMP-2	68,74	MMP-9	19,24	TIMP-2	MMP-9	7077	4318	Gene	Gene	inhibitors|dobj|START_ENTITY inhibitors|nsubj|END_ENTITY	Metalloproteinases MMP-9 , MMP-2 and their tissue inhibitors TIMP-1 , TIMP-2 in peripheral transbronchial lung biopsies of patients with sarcoidosis .
20137537	0	TIMP-2	123,129	MMP-9	95,100	TIMP-2	MMP-9	29543(Tax:10116)	81687(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY Effects|appos|mRNA Effects|appos|mRNA mRNA|compound|END_ENTITY	-LSB- Effects of losartan and simvastatin on collagen content , myocardial expression of MMP-2 mRNA , MMP-9 mRNA and TIMP-1 mRNA , TIMP-2 mRNA in pressure overload rat hearts -RSB- .
23320481	0	TIMP-2	53,59	MMP-9	37,42	TIMP-2	MMP-9	7077	4318	Gene	Gene	complex|compound|START_ENTITY complex|dep|Circulating Circulating|dobj|metalloproteinase metalloproteinase|amod|END_ENTITY	Circulating matrix metalloproteinase MMP-9 and MMP-2 / TIMP-2 complex are associated with spontaneous early_pregnancy_failure .
25441368	0	TIMP-2	85,91	MMP-9	48,53	TIMP-2	MMP-9	7077	4318	Gene	Gene	TIMP-1|dep|START_ENTITY Matrix_Metalloproteinases|appos|TIMP-1 Matrix_Metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Expression of Matrix_Metalloproteinases -LRB- MMP-2 , MMP-9 -RRB- and their Inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in Canine Testis , Epididymis and Semen .
26823777	0	TIMP-2	20,26	MMP-9	14,19	TIMP-2	MMP-9	7077	4318	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of MMP-9 / TIMP-2 in nasal_polyps and its functional implications .
10995877	0	TIMP-2	94,100	MT1-MMP	55,62	TIMP-2	MT1-MMP	7077	4323	Gene	Gene	TIMP-1|dep|START_ENTITY matrix_metalloproteinases|appos|TIMP-1 matrix_metalloproteinases|appos|MMP-2 MMP-2|dep|END_ENTITY	Expression of matrix_metalloproteinases -LRB- MMP-2 , MMP-9 , MT1-MMP -RRB- and their inhibitors -LRB- TIMP-1 , TIMP-2 -RRB- in common epithelial_tumors of the ovary .
12630911	0	TIMP-2	61,67	MT1-MMP	169,176	TIMP-2	MT1-MMP	7077	4323	Gene	Gene	tissue_inhibitor_of_metalloproteinases_2|appos|START_ENTITY motifs|nmod|tissue_inhibitor_of_metalloproteinases_2 motifs|acl|determining determining|nmod|END_ENTITY	Sequence motifs of tissue_inhibitor_of_metalloproteinases_2 -LRB- TIMP-2 -RRB- determining progelatinase_A -LRB- proMMP-2 -RRB- binding and activation by membrane-type metalloproteinase 1 -LRB- MT1-MMP -RRB- .
14729066	0	TIMP-2	0,6	MT1-MMP	62,69	TIMP-2	MT1-MMP	7077	4323	Gene	Gene	released|nsubjpass|START_ENTITY released|nmod|molecule molecule|nmod|surface surface|amod|binding binding|nmod|END_ENTITY	TIMP-2 is released as an intact molecule following binding to MT1-MMP on the cell surface .
15095267	0	TIMP-2	127,133	MT1-MMP	36,43	TIMP-2	MT1-MMP	7077	4323	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Activation of pro-MMP-2 mediated by MT1-MMP in human salivary_gland_carcinomas : possible regulation of pro-MMP-2 activation by TIMP-2 .
15451196	0	TIMP-2	119,125	MT1-MMP	58,65	TIMP-2	MT1-MMP	102178107	100861171	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Expression and localization of matrix_metalloproteinases -LRB- MT1-MMP , MMP-2 -RRB- and tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- during synepitheliochorial placentation of goats -LRB- Capra_hircus -RRB- .
26331622	0	TIMP-2	0,6	MT1-MMP	24,31	TIMP-2	MT1-MMP	7077	4323	Gene	Gene	Interaction|compound|START_ENTITY Interaction|nmod|END_ENTITY	TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis .
9422789	0	TIMP-2	41,47	MT1-MMP	153,160	TIMP-2	MT1-MMP	7077	4323	Gene	Gene	Tissue_inhibitor_of_metalloproteinase-2|appos|START_ENTITY binds|nsubj|Tissue_inhibitor_of_metalloproteinase-2 binds|xcomp|membrane_type_1-matrix_metalloproteinase_1 membrane_type_1-matrix_metalloproteinase_1|dep|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- binds to the catalytic domain of the cell surface receptor , membrane_type_1-matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- .
9685743	0	TIMP-2	50,56	MT1-MMP	158,165	TIMP-2	MT1-MMP	7077	4323	Gene	Gene	Role|nmod|START_ENTITY catalyzed|nsubj|Role catalyzed|nmod|membrane-type_matrix_metalloproteinase-1 membrane-type_matrix_metalloproteinase-1|appos|END_ENTITY	Role of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in regulation of pro-gelatinase A activation catalyzed by membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- in human cancer cells .
11694645	0	TIMP-2	87,93	TIMP-1	79,85	TIMP-2	TIMP-1	7077	7076	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
16042227	0	TIMP-2	29,35	TIMP-1	12,18	TIMP-2	TIMP-1	7077	7076	Gene	Gene	ratios|compound|START_ENTITY ratios|amod|END_ENTITY	Serum MMP-9 / TIMP-1 and MMP-2 / TIMP-2 ratios in multiple_sclerosis : relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment .
16374054	0	TIMP-2	86,92	TIMP-1	72,78	TIMP-2	TIMP-1	21858(Tax:10090)	21857(Tax:10090)	Gene	Gene	MMP-2|dep|START_ENTITY MMP-2|compound|END_ENTITY	rd1 mouse retina shows imbalance in cellular distribution and levels of TIMP-1 / MMP-9 , TIMP-2 / MMP-2 and sulfated glycosaminoglycans .
25380883	0	TIMP-2	96,102	TIMP-1	87,93	TIMP-2	TIMP-1	7077	7076	Gene	Gene	START_ENTITY|nsubj|matrix_metalloproteinase-2 matrix_metalloproteinase-2|appos|inhibitor inhibitor|nmod|proteinase-1 proteinase-1|appos|END_ENTITY	Increased plasma matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- , tissue inhibitor of proteinase-1 -LRB- TIMP-1 -RRB- , TIMP-2 , and urine MMP-2 concentrations correlate with proteinuria in renal transplant recipients .
26711243	0	TIMP-2	26,32	TIMP-1	43,49	TIMP-2	TIMP-1	7077	7076	Gene	Gene	Decreases|dep|START_ENTITY END_ENTITY|nsubj|Decreases	Decreases in plasma MMP-2 / TIMP-2 and MMP-9 / TIMP-1 ratios in uremic patients during hemodialysis .
9543631	0	TIMP-2	24,30	TIMP-1	16,22	TIMP-2	TIMP-1	7077	7076	Gene	Gene	gelatinase|amod|START_ENTITY gelatinase|amod|END_ENTITY	Localization of TIMP-1 , TIMP-2 , TIMP-3 , gelatinase A and gelatinase B in pathological human corneas .
7750537	0	TIMP-2	24,30	TIMP-2	45,51	TIMP-2	TIMP-2	7077	7077	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Cell surface binding of TIMP-2 and pro-MMP-2 / TIMP-2 complex .
7750537	0	TIMP-2	45,51	TIMP-2	24,30	TIMP-2	TIMP-2	7077	7077	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Cell surface binding of TIMP-2 and pro-MMP-2 / TIMP-2 complex .
9543631	0	TIMP-2	24,30	TIMP-3	32,38	TIMP-2	TIMP-3	7077	7078	Gene	Gene	gelatinase|amod|START_ENTITY gelatinase|amod|END_ENTITY	Localization of TIMP-1 , TIMP-2 , TIMP-3 , gelatinase A and gelatinase B in pathological human corneas .
10430177	0	TIMP-2	41,47	Tissue_inhibitor_of_metalloproteinase-2	0,39	TIMP-2	Tissue inhibitor of metalloproteinase-2	282093(Tax:9913)	282093(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- expression is strongly induced by ACTH in adrenocortical cells .
16805810	0	TIMP-2	41,47	Tissue_inhibitor_of_metalloproteinase-2	0,39	TIMP-2	Tissue inhibitor of metalloproteinase-2	7077	7077	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- expression is regulated by multiple neural differentiation signals .
8655631	0	TIMP-2	41,47	Tissue_inhibitor_of_metalloproteinase-2	0,39	TIMP-2	Tissue inhibitor of metalloproteinase-2	282093(Tax:9913)	282093(Tax:9913)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- mRNA is constitutively expressed in bovine , human normal , and osteoarthritic articular chondrocytes .
2380196	0	TIMP-2	42,48	Tissue_inhibitor_of_metalloproteinases-2	0,40	TIMP-2	Tissue inhibitor of metalloproteinases-2	7077	7077	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- mRNA expression in tumor cell lines and human tumor tissues .
11042903	0	TIMP-2	131,137	matrix_metalloproteinases_1_and_2	34,67	TIMP-2	matrix metalloproteinases 1 and 2	7077	4312;4313	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of matrix_metalloproteinases_1_and_2 -LRB- MMP-1 and MMP-2 -RRB- and tissue inhibitor of metalloproteinase 2 -LRB- TIMP-2 -RRB- in ruptured and non-ruptured tubal ectopic pregnancies .
17642161	0	TIMP-2	27,33	nm23	14,18	TIMP-2	nm23	7077	4830	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of nm23 , MMP-2 , TIMP-2 in breast_neoplasm in Zhengzhou Center Hospital , China .
11694645	0	TIMP-2	87,93	p53	102,105	TIMP-2	p53	7077	7157	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
17325663	0	TIMP-2	72,78	tissue_inhibitor_of_metalloproteinase-2	31,70	TIMP-2	tissue inhibitor of metalloproteinase-2	7077	7077	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic inactivation of the tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- gene in human prostate_tumors .
19751965	0	TIMP-2	53,59	tissue_inhibitor_of_metalloproteinase-2	12,51	TIMP-2	tissue inhibitor of metalloproteinase-2	7077	7077	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increase in tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- levels and inhibition of MMP-2 activity in a metastatic breast_cancer cell line by an anti-invasive small molecule SR13179 .
10409697	0	TIMP-2	120,126	tissue_inhibitor_of_metalloproteinases-2	78,118	TIMP-2	tissue inhibitor of metalloproteinases-2	7077	7077	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biophysical and functional characterization of full-length , recombinant human tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- produced in Escherichia_coli .
16043896	0	TIMP-2	64,70	tissue_inhibitor_of_metalloproteinases-2	22,62	TIMP-2	tissue inhibitor of metalloproteinases-2	21858(Tax:10090)	21858(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Beneficial effects of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- on chronic_dermatitis .
7490456	0	TIMP-2	59,65	tissue_inhibitor_of_metalloproteinases-2	17,57	TIMP-2	tissue inhibitor of metalloproteinases-2	29543(Tax:10116)	29543(Tax:10116)	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in experimental animals using monoclonal antibodies against TIMP-2-specific oligopeptides .
8761971	0	TIMP-2	62,68	tissue_inhibitor_of_metalloproteinases-2	20,60	TIMP-2	tissue inhibitor of metalloproteinases-2	7077	7077	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in the human placenta .
8886690	0	TIMP-2	78,84	tissue_inhibitor_of_metalloproteinases-2	36,76	TIMP-2	tissue inhibitor of metalloproteinases-2	7077	7077	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in first trimester human placental decidua .
9872597	0	TIMP-2	161,167	tissue_inhibitor_of_metalloproteinases-2	119,159	TIMP-2	tissue inhibitor of metalloproteinases-2	7077	7077	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- gelatinase A , MMP-2 -RRB- , membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- and tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- expression by elastin-derived peptides in human HT-1080 fibrosarcoma cell line .
11694645	0	TIMP-2	87,93	uPA	74,77	TIMP-2	uPA	7077	5328	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
16771712	0	TIMP-3	0,6	ADAMTS-2	45,53	TIMP-3	ADAMTS-2	7078	9509	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2 .
17470431	0	TIMP-3	0,6	ADAMTS-4	21,29	TIMP-3	ADAMTS-4	7078	9507	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	TIMP-3 inhibition of ADAMTS-4 -LRB- Aggrecanase-1 -RRB- is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4 .
12296867	0	TIMP-3	130,136	CD163	121,126	TIMP-3	CD163	7078	9332	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|the the|nmod|END_ENTITY	Elevated levels of soluble CD163 in sera and fluids from rheumatoid_arthritis patients and inhibition of the shedding of CD163 by TIMP-3 .
12296867	0	TIMP-3	130,136	CD163	27,32	TIMP-3	CD163	7078	9332	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of soluble CD163 in sera and fluids from rheumatoid_arthritis patients and inhibition of the shedding of CD163 by TIMP-3 .
24132606	0	TIMP-3	56,62	EZH2	0,4	TIMP-3	EZH2	7078	2146	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	EZH2 regulates cancer cell migration through repressing TIMP-3 in non-small cell lung_cancer .
9543631	0	TIMP-3	32,38	TIMP-1	16,22	TIMP-3	TIMP-1	7078	7076	Gene	Gene	gelatinase|amod|START_ENTITY gelatinase|amod|END_ENTITY	Localization of TIMP-1 , TIMP-2 , TIMP-3 , gelatinase A and gelatinase B in pathological human corneas .
9543631	0	TIMP-3	32,38	TIMP-2	24,30	TIMP-3	TIMP-2	7078	7077	Gene	Gene	gelatinase|amod|START_ENTITY gelatinase|amod|END_ENTITY	Localization of TIMP-1 , TIMP-2 , TIMP-3 , gelatinase A and gelatinase B in pathological human corneas .
26614997	0	TIMP-3	126,132	WIF1	23,27	TIMP-3	WIF1	7078	11197	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of WIF1 in hepatocellular_carcinoma cells and its regulating effect on invasion and metastasis factors of TIMP-3 and caveolin-1 of hepatocellular_carcinoma .
11278243	0	TIMP-3	0,6	aggrecanase_1	32,45	TIMP-3	aggrecanase 1	7078	9507	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	TIMP-3 is a potent inhibitor of aggrecanase_1 -LRB- ADAM-TS4 -RRB- and aggrecanase_2 -LRB- ADAM-TS5 -RRB- .
10022430	0	TIMP-3	108,114	gonadotropin-releasing_hormone	153,183	TIMP-3	gonadotropin-releasing hormone	7078	2796	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Independent regulation of matrix_metalloproteinase-9 , tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- , and TIMP-3 in human endometrial stromal cells by gonadotropin-releasing_hormone : implications in early human implantation .
23936642	0	TIMP-3	89,95	miR-21	68,74	TIMP-3	miR-21	7078	406991	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Genetic heterogeneity of breast_cancer metastasis may be related to miR-21 regulation of TIMP-3 in translation .
10602522	0	TIMP-3	49,55	p53	73,76	TIMP-3	p53	7078	7157	Gene	Gene	START_ENTITY|nmod|mutants mutants|compound|END_ENTITY	Inhibition of the putative tumor suppressor gene TIMP-3 by tumor-derived p53 mutants and wild type p53 .
11353449	0	TIMP-3	87,93	tissue_inhibitor_of_metalloproteinases-3	45,85	TIMP-3	tissue inhibitor of metalloproteinases-3	7078	7078	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Systematic search for mutations in the human tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- gene on chromosome 22 and association study with schizophrenia .
9006089	0	TIMP-3	119,125	tissue_inhibitor_of_metalloproteinases-3	77,117	TIMP-3	tissue inhibitor of metalloproteinases-3	21859(Tax:10090)	21859(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a putative p53 binding site in the promoter of the mouse tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- gene : TIMP-3 is not a p53 target gene .
9540985	0	TIMP-3	56,62	tissue_inhibitor_of_metalloproteinases-3	14,54	TIMP-3	tissue inhibitor of metalloproteinases-3	7078	7078	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Activation of tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- mRNA expression in scleroderma skin fibroblasts .
11178970	0	TIMP-4	22,28	MT1-MMP	67,74	TIMP-4	MT1-MMP	7079	4323	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP .
9182583	0	TIMP-4	151,157	TIMP-4	77,83	TIMP-4	TIMP-4	7079	7079	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Specific , high affinity binding of tissue_inhibitor_of_metalloproteinases-4 -LRB- TIMP-4 -RRB- to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase_A and the COOH-terminal domain in a similar manner to TIMP-2 .
9182583	0	TIMP-4	77,83	TIMP-4	151,157	TIMP-4	TIMP-4	7079	7079	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Specific , high affinity binding of tissue_inhibitor_of_metalloproteinases-4 -LRB- TIMP-4 -RRB- to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase_A and the COOH-terminal domain in a similar manner to TIMP-2 .
11948685	0	TIMP-4	42,48	Tissue_inhibitor_of_metalloproteinases-4	0,40	TIMP-4	Tissue inhibitor of metalloproteinases-4	7079	7079	Gene	Gene	increased|dep|START_ENTITY increased|nsubjpass|END_ENTITY	Tissue_inhibitor_of_metalloproteinases-4 -LRB- TIMP-4 -RRB- gene expression is increased in human osteoarthritic femoral head cartilage .
18502033	0	TIMP1	0,5	CD44	14,18	TIMP1	CD44	7076	960	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	TIMP1 induces CD44 expression and the activation and nuclear translocation of SHP1 during the late centrocyte/post-germinal center B cell differentiation .
12802622	0	TIMP1	168,173	MMP1	106,110	TIMP1	MMP1	7076	4312	Gene	Gene	matrix_metalloproteinases|appos|START_ENTITY matrix_metalloproteinases|appos|END_ENTITY	Effects of a vegetable extract from Lupinus albus -LRB- LU105 -RRB- on the production of matrix_metalloproteinases -LRB- MMP1 , MMP2 , MMP9 -RRB- and tissue_inhibitor_of_metalloproteinases -LRB- TIMP1 , TIMP2 -RRB- by human gingival fibroblasts in culture .
16596214	0	TIMP1	108,113	MMP1	63,67	TIMP1	MMP1	7076	4312	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In situ gene expression and localization of metalloproteinases MMP1 , MMP2 , MMP3 , MMP9 , and their inhibitors TIMP1 and TIMP2 in human renal_cell_carcinoma .
24347177	0	TIMP1	57,62	MMP2	64,68	TIMP1	MMP2	7076	4313	Gene	Gene	IL-6|appos|START_ENTITY IL-6|appos|END_ENTITY	The activation of TLR7 regulates the expression of VEGF , TIMP1 , MMP2 , IL-6 , and IL-15 in Hela cells .
24347177	0	TIMP1	57,62	VEGF	51,55	TIMP1	VEGF	7076	7422	Gene	Gene	IL-6|appos|START_ENTITY IL-6|compound|END_ENTITY	The activation of TLR7 regulates the expression of VEGF , TIMP1 , MMP2 , IL-6 , and IL-15 in Hela cells .
26522657	0	TIMP2	77,82	IGFBP7	66,72	TIMP2	IGFBP7	7077	3490	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Reference intervals of urinary acute_kidney_injury -LRB- AKI -RRB- markers -LSB- IGFBP7 -RSB- -LSB- TIMP2 -RSB- in apparently healthy subjects and chronic comorbid subjects without AKI .
26816218	0	TIMP2	0,5	IGFBP7	8,14	TIMP2	IGFBP7	7077	3490	Gene	Gene	panel|nummod|START_ENTITY panel|compound|END_ENTITY	TIMP2 IGFBP7 biomarker panel accurately predicts acute_kidney_injury in high-risk surgical patients .
24440352	0	TIMP2	22,27	MicroRNA-106a	0,13	TIMP2	MicroRNA-106a	7077	406899	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-106a targets TIMP2 to regulate invasion and metastasis of gastric_cancer .
22551568	0	TIMP2	33,38	NUR77	0,5	TIMP2	NUR77	7077	3164	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	NUR77 inhibits the expression of TIMP2 and increases the migration and invasion of HTR-8 / SVneo cells induced by CYR61 .
16106100	0	TIMP2	72,77	endostatin	15,25	TIMP2	endostatin	7077	80781	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of endostatin and tissue_inhibitor_of_metalloproteinases_2 -LRB- TIMP2 -RRB- serum levels with cardiovascular_involvement in systemic_sclerosis patients .
26464662	0	TIMP2	59,64	miR-301a	0,8	TIMP2	miR-301a	7077	407027	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-301a promotes cell proliferation by directly targeting TIMP2 in multiple myeloma .
26191221	0	TIMP2	70,75	miRNA-221	0,9	TIMP2	miRNA-221	7077	407006	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miRNA-221 promotes proliferation , migration and invasion by targeting TIMP2 in renal_cell_carcinoma .
25153068	0	TIMP2	138,143	tissue_inhibitor_of_metalloproteinase_2	97,136	TIMP2	tissue inhibitor of metalloproteinase 2	7077	7077	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	A chromatin modifier regulates Sertoli cell response to mono - -LRB- 2-ethylhexyl -RRB- _ phthalate -LRB- MEHP -RRB- via tissue_inhibitor_of_metalloproteinase_2 -LRB- TIMP2 -RRB- signaling .
26872030	0	TIMP3	47,52	MMP2	79,83	TIMP3	MMP2	25358(Tax:10116)	81686(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|END_ENTITY	The Angiogenic Effect of microRNA-21 Targeting TIMP3 through the Regulation of MMP2 and MMP9 .
15714128	0	TIMP3	60,65	tissue_inhibitor_of_metalloproteinase-3	19,58	TIMP3	tissue inhibitor of metalloproteinase-3	7078	7078	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alterations of the tissue_inhibitor_of_metalloproteinase-3 -LRB- TIMP3 -RRB- gene in pancreatic_adenocarcinomas .
9573343	0	TIMP3	82,87	tissue_inhibitor_of_metalloproteinases-3	40,80	TIMP3	tissue inhibitor of metalloproteinases-3	373596(Tax:8355)	373596(Tax:8355)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Cloning and developmental regulation of tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP3 -RRB- in Xenopus_laevis early embryos .
9693046	0	TIMP4	67,72	tissue_inhibitor_of_metalloproteinase-4	21,60	TIMP4	tissue inhibitor of metalloproteinase-4	7079	7079	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the human tissue_inhibitor_of_metalloproteinase-4 gene -LRB- TIMP4 -RRB- and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6 , respectively .
15133513	0	TIN2	0,4	TRF1	44,48	TIN2	TRF1	26277	7013	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|complex complex|compound|END_ENTITY	TIN2 is a tankyrase_1 PARP modulator in the TRF1 telomere length control complex .
15316005	0	TIN2	0,4	TRF1	11,15	TIN2	TRF1	26277	7013	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres .
20127252	0	TIN2	26,30	TRF1	14,18	TIN2	TRF1	26277	7013	Gene	Gene	KU70|appos|START_ENTITY KU70|compound|END_ENTITY	Expression of TRF1 , TRF2 , TIN2 , TERT , KU70 , and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric_cancer .
15292264	0	TIN2	0,4	TRF2	27,31	TIN2	TRF2	26277	7014	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|functions functions|nmod|END_ENTITY	TIN2 mediates functions of TRF2 at human telomeres .
14769789	0	TINO	18,22	BCL-2	55,60	TINO	BCL-2	399664	596	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of TINO : a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein .
8624440	0	TINY	85,89	APETALA2	122,130	TINY	APETALA2	832650(Tax:3702)	829845(Tax:3702)	Gene	Gene	START_ENTITY|appos|gene gene|acl|related related|nmod|END_ENTITY	A Dissociation insertion causes a semidominant mutation that increases expression of TINY , an Arabidopsis gene related to APETALA2 .
25095751	0	TIP	65,68	tonoplast_intrinsic_protein	36,63	TIP	tonoplast intrinsic protein	10524	10524	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Genome-wide comparative analysis of tonoplast_intrinsic_protein -LRB- TIP -RRB- genes in plants .
11798178	0	TIP-2	19,24	5T4	0,3	TIP-2	5T4	10755	7162	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	5T4 interacts with TIP-2 / GIPC , a PDZ protein , with implications for metastasis .
23088399	0	TIP110	17,23	C-MYC	0,5	TIP110	C-MYC	9733	4609	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells .
15073177	0	TIP30	0,5	CIA	72,75	TIP30	CIA	53415(Tax:10090)	228869(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TIP30 interacts with an estrogen_receptor_alpha-interacting coactivator CIA and regulates c-myc transcription .
23178973	0	TIP30	0,5	p53	21,24	TIP30	p53	10553	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|protein protein|compound|END_ENTITY	TIP30 directly binds p53 tumor suppressor protein in vitro .
23936516	0	TIP47	29,34	perilipin-3	16,27	TIP47	perilipin-3	10226	10226	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Crucial role of perilipin-3 -LRB- TIP47 -RRB- in formation of lipid_droplets and PGE2 production in HL-60-derived neutrophils .
21858214	0	TIP60	21,26	GPR50	0,5	TIP60	GPR50	10524	9248	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GPR50 interacts with TIP60 to modulate glucocorticoid_receptor signalling .
20100829	0	TIP60	74,79	SIRT1	0,5	TIP60	SIRT1	10524	23411	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60 .
26650545	0	TIPE2	0,5	MMP13	54,59	TIPE2	MMP13	79626	4322	Gene	Gene	Mediates|nsubj|START_ENTITY Mediates|nmod|END_ENTITY	TIPE2 Mediates the Suppressive Effects of Shikonin on MMP13 in Osteosarcoma Cells .
27043859	0	TIPE2	18,23	VEGF	44,48	TIPE2	VEGF	79626	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Anti-inflammatory TIPE2 inhibits angiogenic VEGF in retinal_pigment_epithelium .
26781452	0	TIPE2	0,5	p27	56,59	TIPE2	p27	69769(Tax:10090)	22428(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TIPE2 , a negative regulator of TLR signaling , regulates p27 through IRF4-induced signaling .
26717153	0	TIPRL	0,5	Phosphatase_4	23,36	TIPRL	Phosphatase 4	261726	5531	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Activity Activity|compound|END_ENTITY	TIPRL Inhibits Protein Phosphatase_4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response .
23523351	0	TIR-1	74,79	JNK-1	80,85	TIR-1	JNK-1	175502(Tax:6239)	177460(Tax:6239)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Forgetting in C. _ elegans is accelerated by neuronal communication via the TIR-1 / JNK-1 pathway .
15208392	0	TIR1	138,142	SCF	134,137	TIR1	SCF	825473(Tax:3702)	4254	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Arabidopsis ETA2 , an apparent ortholog of the human cullin-interacting protein CAND1 , is required for auxin responses mediated by the SCF -LRB- TIR1 -RRB- ubiquitin ligase .
20402793	0	TIR1	70,74	Snf7p	15,20	TIR1	Snf7p	856729(Tax:4932)	850712(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Involvement of Snf7p and Rim101p in the transcriptional regulation of TIR1 and other anaerobically upregulated genes in Saccharomyces_cerevisiae .
21218381	0	TIRAP	15,20	MAL	22,25	TIRAP	MAL	114609	4118	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of TIRAP -LRB- MAL -RRB- gene polymorhisms with susceptibility to tuberculosis in a Chinese population .
21829704	0	TIRAP	0,5	RAGE	63,67	TIRAP	RAGE	114609	177	Gene	Gene	transduces|nsubj|START_ENTITY transduces|nmod|END_ENTITY	TIRAP , an adaptor protein for TLR2/4 , transduces a signal from RAGE phosphorylated upon ligand binding .
21829704	0	TIRAP	0,5	TLR2/4	30,36	TIRAP	TLR2/4	114609	7097;7099	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	TIRAP , an adaptor protein for TLR2/4 , transduces a signal from RAGE phosphorylated upon ligand binding .
19592497	0	TIRAP	25,30	TRAF6	48,53	TIRAP	TRAF6	117149(Tax:10090)	22034(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	MyD88 adapter-like -LRB- Mal -RRB- / TIRAP interaction with TRAF6 is critical for TLR2 - and TLR4-mediated NF-kappaB proinflammatory responses .
19801654	0	TIS11B	41,47	Von_Hippel-Lindau	0,17	TIS11B	Von Hippel-Lindau	677	7428	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Von_Hippel-Lindau gene product modulates TIS11B expression in renal_cell_carcinoma : impact on vascular_endothelial_growth_factor expression in hypoxia .
10887131	0	TIS11b	110,116	ERF-1	118,123	TIS11b	ERF-1	677	677	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of genes under the downstream control of the t -LRB- 8 ; 21 -RRB- fusion protein AML1-MTG8 : overexpression of the TIS11b -LRB- ERF-1 , cMG1 -RRB- gene induces myeloid cell proliferation in response to G-CSF .
23917204	0	TIS21	0,5	interleukin-6	26,39	TIS21	interleukin-6	7832	3569	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TIS21 -LRB- / BTG2/PC3 -RRB- inhibits interleukin-6 expression via downregulation of STAT3 pathway .
11237868	0	TIS21	19,24	rPICK1	88,94	TIS21	rPICK1	12227(Tax:10090)	84591(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1 .
16204248	0	TIS7	0,4	osteopontin	54,65	TIS7	osteopontin	15982(Tax:10090)	20750(Tax:10090)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	TIS7 regulation of the beta-catenin/Tcf -4 target gene osteopontin -LRB- OPN -RRB- is histone deacetylase-dependent .
10403172	0	TITF2	120,125	thyroid_transcription_factor_2	83,113	TITF2	thyroid transcription factor 2	2304	2304	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning , chromosomal localization and identification of polymorphisms in the human thyroid_transcription_factor_2 gene -LRB- TITF2 -RRB- .
3022474	0	TK	18,20	Thymidine_kinase	0,16	TK	Thymidine kinase	24271467	24271467	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Thymidine_kinase -LRB- TK -RRB- activity in herpes_simplex_virus_type_1 recombinants that carry insertions affecting regulation of the TK gene .
2543766	0	TK	60,62	thymidine_kinase	42,58	TK	thymidine kinase	1487380(Tax:10320)	1487380(Tax:10320)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of the bovine_herpesvirus_type_1 thymidine_kinase -LRB- TK -RRB- gene from wild-type virus and TK-deficient mutants .
12527796	0	TK-2	61,65	thymidine_kinase	43,59	TK-2	thymidine kinase	7084	24271467	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|nmod|END_ENTITY	Non-nucleoside inhibitors of mitochondrial thymidine_kinase -LRB- TK-2 -RRB- differentially inhibit the closely related herpes_simplex_virus_type_1 TK and Drosophila_melanogaster multifunctional deoxynucleoside kinase .
22143937	0	TK1	25,28	thymidine_kinase_1	5,23	TK1	thymidine kinase 1	7083	7083	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	High thymidine_kinase_1 -LRB- TK1 -RRB- expression is a predictor of poor survival in patients with pT1 of lung_adenocarcinoma .
17322372	0	TK2	70,73	thymidine_kinase	52,68	TK2	thymidine kinase	57813(Tax:10090)	57813(Tax:10090)	Gene	Gene	overexpression|appos|START_ENTITY overexpression|nmod|END_ENTITY	Targeted transgenic overexpression of mitochondrial thymidine_kinase -LRB- TK2 -RRB- alters mitochondrial DNA -LRB- mtDNA -RRB- and mitochondrial polypeptide abundance : transgenic TK2 , mtDNA , and antiretrovirals .
23932787	0	TK2	147,150	thymidine_kinase	129,145	TK2	thymidine kinase	7084	7084	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular and clinical characterization of the myopathic form of mitochondrial_DNA_depletion_syndrome caused by mutations in the thymidine_kinase -LRB- TK2 -RRB- gene .
9521875	0	TKT	25,28	transketolase	10,23	TKT	transketolase	21881(Tax:10090)	21881(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse transketolase -LRB- TKT -RRB- gene : cloning , characterization , and functional promoter analysis .
17342325	0	TKTL1	22,27	Transketolase	0,13	TKTL1	Transketolase	8277	7086	Gene	Gene	overexpression|compound|START_ENTITY overexpression|amod|END_ENTITY	Transketolase protein TKTL1 overexpression : A potential biomarker and therapeutic target in breast_cancer .
17351395	0	TKTL1	4,9	transketolase	32,45	TKTL1	transketolase	8277	7086	Gene	Gene	gene|compound|START_ENTITY influences|nsubj|gene influences|dobj|activity activity|compound|END_ENTITY	The TKTL1 gene influences total transketolase activity and cell proliferation in human colon_cancer LoVo cells .
23261987	0	TKTL1	31,36	transketolase	38,51	TKTL1	transketolase	8277	7086	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Is transketolase-like protein , TKTL1 , transketolase ?
20592357	0	TKTL1	44,49	transketolase-like_1_protein	14,42	TKTL1	transketolase-like 1 protein	8277	8277	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of transketolase-like_1_protein -LRB- TKTL1 -RRB- in human endometrial_cancer .
25148371	0	TL1A	0,4	CD25	29,33	TL1A	CD25	9966	3559	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	TL1A increases expression of CD25 , LFA-1 , CD134 and CD154 , and induces IL-22 and GM-CSF production from effector CD4 T-cells .
11911831	0	TL1A	0,4	DR3	30,33	TL1A	DR3	9966	8718	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator .
19834969	0	TL1A	0,4	IL-23	102,107	TL1A	IL-23	9966	51561	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn 's _ disease .
24416448	0	TL1A	0,4	IL-6	29,33	TL1A	IL-6	9966	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TL1A induces TCR independent IL-6 and TNF-a production and growth of PLZF leukocytes .
27081759	0	TL1A	0,4	IL-6	15,19	TL1A	IL-6	9966	3569	Gene	Gene	increased|nsubj|START_ENTITY increased|dobj|production production|compound|END_ENTITY	TL1A increased IL-6 production on fibroblast-like synoviocytes by preferentially activating TNF receptor 2 in rheumatoid_arthritis .
20863486	0	TL1A	0,4	THP-1	94,99	TL1A	THP-1	9966	2736	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|compound|END_ENTITY	TL1A induces the expression of TGF-b-inducible gene h3 -LRB- big-h3 -RRB- through PKC , PI3K , and ERK in THP-1 cells .
19251437	0	TL1A	52,56	TNFSF15	43,50	TL1A	TNFSF15	9966	9966	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Effect of sodium_butyrate on lung vascular TNFSF15 -LRB- TL1A -RRB- expression : differential expression patterns in pulmonary artery and microvascular endothelial cells .
19262684	0	TL1A	15,19	TNFSF15	26,33	TL1A	TNFSF15	9966	9966	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	IBD-associated TL1A gene -LRB- TNFSF15 -RRB- haplotypes determine increased expression of TL1A protein .
21264313	0	TL1A	13,17	TNFSF15	19,26	TL1A	TNFSF15	326623(Tax:10090)	326623(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Constitutive TL1A -LRB- TNFSF15 -RRB- expression on lymphoid or myeloid cells leads to mild intestinal_inflammation and fibrosis .
23638306	0	TL1A	10,14	TNFSF15	16,23	TL1A	TNFSF15	326623(Tax:10090)	326623(Tax:10090)	Gene	Gene	EXPRESSION|compound|START_ENTITY EXPRESSION|appos|END_ENTITY	SUSTAINED TL1A -LRB- TNFSF15 -RRB- EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS .
19834969	0	TL1A	0,4	Th1	52,55	TL1A	Th1	9966	51497	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn 's _ disease .
22593543	0	TL1A	21,25	death_receptor_3	4,20	TL1A	death receptor 3	326623(Tax:10090)	85030(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY END_ENTITY|parataxis|essential	The death_receptor_3 / TL1A pathway is essential for efficient development of antiviral CD4 and CD8 T-cell immunity .
25446087	0	TLE1	0,4	E-cadherin	67,77	TLE1	E-cadherin	7088	999	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	TLE1 promotes EMT in A549 lung_cancer cells through suppression of E-cadherin .
20181723	0	TLE1	13,17	HESX1	41,46	TLE1	HESX1	21885(Tax:10090)	15209(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Corepressors TLE1 and TLE3 interact with HESX1 and PROP1 .
15767669	0	TLF/TRF2	162,170	neurofibromatosis_type_1	118,142	TLF/TRF2	neurofibromatosis type 1	109824;237336	18015(Tax:10090)	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	TATA-binding_protein _ -LRB- TBP -RRB- - like_factor -LRB- TLF -RRB- is a functional regulator of transcription : reciprocal regulation of the neurofibromatosis_type_1 and c-fos genes by TLF/TRF2 and TBP .
23418473	0	TLP	32,35	TRAP-1-like_protein	11,30	TLP	TRAP-1-like protein	23339	23339	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of TRAP-1-like_protein -LRB- TLP -RRB- gene on collagen synthesis induced by TGF-b/Smad signaling in human dermal fibroblasts .
21674065	0	TLR-2	31,36	BCR	44,47	TLR-2	BCR	7097	613	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	CD40 signaling synergizes with TLR-2 in the BCR independent activation of resting_B cells .
25790134	0	TLR-2	0,5	CD25	50,54	TLR-2	CD25	24088(Tax:10090)	16184(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|Foxp3 Foxp3|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
25790134	0	TLR-2	0,5	CD4	46,49	TLR-2	CD4	24088(Tax:10090)	12504(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|Foxp3 Foxp3|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
25790134	0	TLR-2	0,5	Foxp3	55,60	TLR-2	Foxp3	24088(Tax:10090)	20371(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
25790134	0	TLR-2	0,5	IL-17A	25,31	TLR-2	IL-17A	24088(Tax:10090)	16171(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	TLR-2 Signaling Promotes IL-17A Production in CD4 + CD25 + Foxp3 + Regulatory Cells during Oropharyngeal_Candidiasis .
26477714	0	TLR-2	82,87	NF-kB	110,115	TLR-2	NF-kB	310553(Tax:10116)	309165(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activation activation|nmod|END_ENTITY	Candidaglabrata induced infection of rat tracheal epithelial cells is mediated by TLR-2 induced activation of NF-kB .
17467812	0	TLR-2	96,101	RANKL	86,91	TLR-2	RANKL	7097	8600	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation .
22749982	0	TLR-4	90,95	CD4	61,64	TLR-4	CD4	7099	920	Gene	Gene	CD25|dep|START_ENTITY CD25|compound|END_ENTITY	Induction of CD152 -LRB- CTLA-4 -RRB- and LAP -LRB- TGF-b1 -RRB- in human Foxp3 - CD4 + CD25 - T cells modulates TLR-4 induced TNF-a production .
12561375	0	TLR-4	27,32	IL-8	57,61	TLR-4	IL-8	7099	3576	Gene	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	-LSB- Assessment of the role of TLR-4 in shear-stress-induced IL-8 gene transcription activation in vascular endothelial cells by gene mutation and gene transfection technology -RSB- .
16303092	0	TLR-4	14,19	MD-2	20,24	TLR-4	MD-2	7099	23643	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|signaling signaling|nsubj|END_ENTITY	Inhibition of TLR-4 / MD-2 signaling by RP105/MD -1 .
21293887	0	TLR-4	18,23	STAT3	44,49	TLR-4	STAT3	7099	6774	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle .
23844229	0	TLR-4	6,11	TREM-1	12,18	TLR-4	TREM-1	7099	54210	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	TLR-2 / TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney_injury .
25759837	0	TLR-4	42,47	Toll-Like_Receptor-4	20,40	TLR-4	Toll-Like Receptor-4	21898(Tax:10090)	21898(Tax:10090)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Toll-Like_Receptor-4 -LRB- TLR-4 -RRB- in the Spleen and Thymus of Swiss Albino Mice and Its Modulation in Experimental Endotoxemia .
11728442	0	TLR-4	93,98	antithrombin_III	30,46	TLR-4	antithrombin III	7099	462	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The serine_protease inhibitor antithrombin_III inhibits LPS-mediated NF-kappaB activation by TLR-4 .
23483583	0	TLR-4	20,25	lipocalin_2	35,46	TLR-4	lipocalin 2	21898(Tax:10090)	16819(Tax:10090)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	Nitric_oxide boosts TLR-4 mediated lipocalin_2 expression in chondrocytes .
26187476	0	TLR-4	127,132	p65	138,141	TLR-4	p65	7099	5970	Gene	Gene	signal|compound|START_ENTITY signal|amod|END_ENTITY	Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4 / NFkB p65 signal pathway .
25280922	0	TLR-4	57,62	toll-like_receptor-4	35,55	TLR-4	toll-like receptor-4	7099	7099	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Evaluation of four a-diketones for toll-like_receptor-4 -LRB- TLR-4 -RRB- activation in a human transfected cell line .
16517754	0	TLR-7	40,45	IL-2	17,21	TLR-7	IL-2	51284	3558	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Sensitization of IL-2 signaling through TLR-7 enhances B_lymphoma cell immunogenicity .
17785827	0	TLR1	40,44	Idd6	26,30	TLR1	Idd6	21897(Tax:10090)	107835(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	The type 1 diabetes locus Idd6 controls TLR1 expression .
22447933	0	TLR1	28,32	PRAT4A	79,85	TLR1	PRAT4A	7096	10695	Gene	Gene	trafficking|nmod|START_ENTITY regulated|nsubjpass|trafficking regulated|nmod|END_ENTITY	Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B .
25544311	0	TLR1	21,25	Toll-like_receptor_1	0,20	TLR1	Toll-like receptor 1	7096	7096	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Toll-like_receptor_1 -LRB- TLR1 -RRB- Gene SNP rs5743618 is associated with increased risk for tuberculosis in Han Chinese children .
17641056	0	TLR10	16,21	FOXP3	0,5	TLR10	FOXP3	81793	50943	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FOXP3 regulates TLR10 expression in human T regulatory cells .
21827211	0	TLR2	60,64	14-3-3	50,56	TLR2	14-3-3	7097	10971	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Identification and functional characterization of 14-3-3 in TLR2 signaling .
23261454	0	TLR2	0,4	ABCA1	16,21	TLR2	ABCA1	24088(Tax:10090)	11303(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|nummod|END_ENTITY	TLR2 stimulates ABCA1 expression via PKC - and PLD2 pathway .
16469054	0	TLR2	0,4	B7-1	38,42	TLR2	B7-1	24088(Tax:10090)	12519(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	TLR2 and TLR4 differentially regulate B7-1 resulting in distinct cytokine responses to the mycoplasma superantigen MAM as well as to disease induced by Mycoplasma_arthritidis .
16670636	0	TLR2	0,4	CD14	12,16	TLR2	CD14	7097	929	Gene	Gene	CD11B|compound|START_ENTITY CD11B|appos|END_ENTITY	TLR2 , TLR4 , CD14 , CD11B , and CD11C expressions on monocytes surface and cytokine production in patients with sepsis , severe sepsis , and septic_shock .
17565650	0	TLR2	56,60	CD14	25,29	TLR2	CD14	7097	929	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Genetic polymorphisms of CD14 and Toll-like_receptor-2 -LRB- TLR2 -RRB- in patients with ulcerative_colitis .
18559343	0	TLR2	88,92	CD14	113,117	TLR2	CD14	7097	929	Gene	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	Oxidized phospholipid inhibition of toll-like receptor -LRB- TLR -RRB- signaling is restricted to TLR2 and TLR4 : roles for CD14 , LPS-binding_protein , and MD2 as targets for specificity of inhibition .
19080469	5	TLR2	1759,1763	CD14	1776,1780	TLR2	CD14	7097	929	Gene	Gene	rmfi|nmod|START_ENTITY rmfi|nmod|monocytes monocytes|nummod|END_ENTITY	The rmfi of TLR2 and TLR4 on CD14 + monocytes of the healthy smokers was lower than that of the nonsmokers -LRB- P < 0.05 -RRB- , while the rpcp of TLR2 and TLR4 on CD14 + monocytes of the healthy smokers was similar to that of the nonsmoker -LRB- P < 0.05 -RRB- .
20113368	0	TLR2	26,30	CD14	119,123	TLR2	CD14	24088(Tax:10090)	12475(Tax:10090)	Gene	Gene	Toll-like_receptor_2|appos|START_ENTITY ligand|nsubj|Toll-like_receptor_2 ligand|ccomp|internalized internalized|nmod|pathway pathway|acl|triggered triggered|nmod|END_ENTITY	The Toll-like_receptor_2 -LRB- TLR2 -RRB- ligand FSL-1 is internalized via the clathrin-dependent endocytic pathway triggered by CD14 and CD36 but not by TLR2 .
22809173	0	TLR2	61,65	CD14	79,83	TLR2	CD14	7097	929	Gene	Gene	Th17|nmod|START_ENTITY differentiation|nmod|Th17 differentiation|nmod|monocytes monocytes|nummod|+ +|compound|END_ENTITY	HMGB1 promotes the differentiation of Th17 via up-regulating TLR2 and IL-23 of CD14 + monocytes from patients with rheumatoid_arthritis .
25942429	0	TLR2	0,4	CD14	28,32	TLR2	CD14	7097	929	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	TLR2 and TLR4 expression on CD14 -LRB- + + -RRB- and CD14 -LRB- + -RRB- monocyte subtypes in adult-onset autoimmune_diabetes .
16767222	0	TLR2	80,84	CD25	36,40	TLR2	CD25	7097	3559	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Heat_shock protein 60 enhances CD4 + CD25 + regulatory T cell function via innate TLR2 signaling .
19882655	0	TLR2	90,94	CD25	4,8	TLR2	CD25	24088(Tax:10090)	16184(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma_japonicum is TLR2 dependent .
16337148	0	TLR2	0,4	CD4	81,84	TLR2	CD4	24088(Tax:10090)	12504(Tax:10090)	Gene	Gene	ameliorates|compound|START_ENTITY murine|nsubj|ameliorates murine|dep|inducing inducing|dobj|apoptosis apoptosis|nummod|END_ENTITY	TLR2 agonist ameliorates murine experimental allergic_conjunctivitis by inducing CD4 positive T-cell apoptosis rather than by affecting the Th1/Th2 balance .
16767222	0	TLR2	80,84	CD4	31,34	TLR2	CD4	7097	920	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Heat_shock protein 60 enhances CD4 + CD25 + regulatory T cell function via innate TLR2 signaling .
19882655	0	TLR2	90,94	CD4	0,3	TLR2	CD4	24088(Tax:10090)	12504(Tax:10090)	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|Treg Treg|compound|END_ENTITY	CD4 + CD25 + Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma_japonicum is TLR2 dependent .
20157599	0	TLR2	27,31	CD4	35,38	TLR2	CD4	7097	920	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Expression and Function of TLR2 on CD4 Versus CD8 T Cells .
21273544	0	TLR2	14,18	CD4	67,70	TLR2	CD4	100009578(Tax:9986)	100009152(Tax:9986)	Gene	Gene	Engagement|nmod|START_ENTITY reverses|nsubj|Engagement reverses|dobj|function function|nmod|cells cells|compound|END_ENTITY	Engagement of TLR2 reverses the suppressor function of conjunctiva CD4 + CD25 + regulatory T cells and promotes herpes_simplex_virus epitope-specific CD4 + CD25 - effector T cell responses .
22467654	0	TLR2	61,65	CD4	107,110	TLR2	CD4	7097	920	Gene	Gene	cells|nmod|START_ENTITY activate|dobj|cells activate|advcl|facilitating facilitating|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Herpes simplex virus antigens directly activate NK cells via TLR2 , thus facilitating their presentation to CD4 T lymphocytes .
23628056	0	TLR2	53,57	CD4	19,22	TLR2	CD4	7097	920	Gene	Gene	Changes|appos|START_ENTITY Changes|appos|CD25 CD25|compound|END_ENTITY	-LSB- Changes of FoxP3 , CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , TLR2 and TLR9 in children with infectious_mononucleosis -RSB- .
24497180	0	TLR2	0,4	CD4	19,22	TLR2	CD4	24088(Tax:10090)	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|engagement engagement|nmod|T T|compound|END_ENTITY	TLR2 engagement on CD4 -LRB- + -RRB- T cells enhances effector functions and protective responses to Mycobacterium_tuberculosis .
26079624	0	TLR2	24,28	CD4	32,35	TLR2	CD4	7097	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Increased expression of TLR2 in CD4 -LRB- + -RRB- T cells from SLE patients enhances immune reactivity and promotes IL-17 expression through histone modifications .
20157599	0	TLR2	27,31	CD8	46,49	TLR2	CD8	7097	925	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|Cells Cells|compound|END_ENTITY	Expression and Function of TLR2 on CD4 Versus CD8 T Cells .
22442665	0	TLR2	0,4	CYP1A1	52,58	TLR2	CYP1A1	24088(Tax:10090)	13076(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	TLR2 controls intestinal carcinogen detoxication by CYP1A1 .
18549457	0	TLR2	25,29	Dectin-1	0,8	TLR2	Dectin-1	7097	64581	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages .
23787127	0	TLR2	37,41	Dectin-1	95,103	TLR2	Dectin-1	7097	64581	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Species-specific PAMP recognition by TLR2 and evidence for species-restricted interaction with Dectin-1 .
23844079	0	TLR2	9,13	Dectin-1	0,8	TLR2	Dectin-1	7097	64581	Gene	Gene	agonists|compound|START_ENTITY render|nsubj|agonists END_ENTITY|parataxis|render	Dectin-1 / TLR2 and NOD2 agonists render dendritic cells susceptible to infection by X4-using HIV-1 and promote cis-infection of CD4 -LRB- + -RRB- T cells .
23628056	0	TLR2	53,57	FoxP3	12,17	TLR2	FoxP3	7097	50943	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	-LSB- Changes of FoxP3 , CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells , TLR2 and TLR9 in children with infectious_mononucleosis -RSB- .
22078319	0	TLR2	42,46	GRK5	34,38	TLR2	GRK5	24088(Tax:10090)	14773(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Overlapping and distinct roles of GRK5 in TLR2 - , and TLR3-induced inflammatory response in vivo .
22528050	0	TLR2	31,35	HspA1A	19,25	TLR2	HspA1A	7097	3303	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian_cancer cells in vitro .
24043885	0	TLR2	68,72	IL-1b	35,40	TLR2	IL-1b	7097	3553	Gene	Gene	activation|compound|START_ENTITY monocytes|nmod|activation END_ENTITY|nmod|monocytes	Inflammasome-mediated secretion of IL-1b in human monocytes through TLR2 activation ; modulation by dietary fatty_acids .
24323452	0	TLR2	49,53	IL-1b	39,44	TLR2	IL-1b	7097	3553	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Protein-bound polysaccharide-K induces IL-1b via TLR2 and NLRP3 inflammasome activation .
23209321	0	TLR2	48,52	IRAK4	23,28	TLR2	MyD88	24088(Tax:10090)	4615	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Complete dependence on IRAK4 kinase activity in TLR2 , but not TLR4 , signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus_pneumoniae_infection in IRAK4 kinase-inactive mice .
23197261	0	TLR2	22,26	MARCO	0,5	TLR2	MARCO	24088(Tax:10090)	17167(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY required|nmod|responses required|nsubjpass|END_ENTITY	MARCO is required for TLR2 - and Nod2-mediated responses to Streptococcus_pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx .
26694804	0	TLR2	128,132	MCP1	163,167	TLR2	MCP1	24088(Tax:10090)	17224(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	A peptide tetramer Tk-tPN induces tolerance of cardiac allo-grafting by conversion of type-1 to type-2 immune responses via the TLR2 signal-promoted activation of MCP1 gene .
19124728	0	TLR2	57,61	NF-kappa_B	34,44	TLR2	NF-kappa B	7097	4790	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	The EBV-encoded dUTPase activates NF-kappa_B through the TLR2 and MyD88-dependent signaling pathway .
22848741	0	TLR2	21,25	NOD1	0,4	TLR2	NOD1	7097	10392	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells .
18773284	0	TLR2	30,34	NOD2	96,100	TLR2	NOD2	7097	64127	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|stimulation stimulation|compound|END_ENTITY	Higher monocyte expression of TLR2 and TLR4 , and enhanced pro-inflammatory synergy of TLR2 with NOD2 stimulation in sarcoidosis .
24376539	0	TLR2	0,4	PD-L2	15,20	TLR2	PD-L2	101055400	574057(Tax:9823)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TLR2 directing PD-L2 expression inhibit T cells response in Schistosoma_japonicum infection .
21899893	0	TLR2	30,34	SPLUNC1	51,58	TLR2	SPLUNC1	7097	51297	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	MAPK/AP -1 activation mediates TLR2 agonist-induced SPLUNC1 expression in human lung epithelial cells .
20400705	0	TLR2	25,29	ST2	0,3	TLR2	ST2	24088(Tax:10090)	17082(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|dobj|signaling regulates|nsubj|END_ENTITY	ST2 negatively regulates TLR2 signaling , but is not required for bacterial lipoprotein-induced tolerance .
11502220	0	TLR2	141,145	TLR4	118,122	TLR2	TLR4	7097	7099	Gene	Gene	Reconstitution|nmod|START_ENTITY Reconstitution|compound|END_ENTITY	Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor -LRB- TLR -RRB- 2 as well as TLR4 Reconstitution of TLR2 - and TLR4-activation by distinguishable ligands in LPS preparations .
14561708	0	TLR2	23,27	TLR4	0,4	TLR2	TLR4	24088(Tax:10090)	21898(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY induces|dobj|expression induces|nsubj|signaling signaling|compound|END_ENTITY	TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase .
15349893	0	TLR2	54,58	TLR4	43,47	TLR2	TLR4	7097	7099	Gene	Gene	receptor|dep|START_ENTITY receptor|appos|END_ENTITY	Selective priming to Toll-like receptor 4 -LRB- TLR4 -RRB- , not TLR2 , ligands by P. _ acnes involves up-regulation of MD-2 in mice .
15585882	0	TLR2	30,34	TLR4	130,134	TLR2	TLR4	7097	7099	Gene	Gene	blocks|compound|START_ENTITY released|nmod|blocks released|dobj|induction induction|acl:relcl|induced induced|nmod|END_ENTITY	IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells .
16272176	0	TLR2	71,75	TLR4	48,52	TLR2	TLR4	24088(Tax:10090)	21898(Tax:10090)	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nummod|END_ENTITY	Hemorrhagic_shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages : role in hemorrhage-primed_lung_inflammation .
16604477	0	TLR2	102,106	TLR4	108,112	TLR2	TLR4	101055400	399541(Tax:9823)	Gene	Gene	TLR5|compound|START_ENTITY TLR5|appos|END_ENTITY	Biased distribution of single nucleotide polymorphisms -LRB- SNPs -RRB- in porcine Toll-like_receptor_1 -LRB- TLR1 -RRB- , TLR2 , TLR4 , TLR5 , and TLR6 genes .
16670636	0	TLR2	0,4	TLR4	6,10	TLR2	TLR4	7097	7099	Gene	Gene	CD11B|compound|START_ENTITY CD11B|appos|END_ENTITY	TLR2 , TLR4 , CD14 , CD11B , and CD11C expressions on monocytes surface and cytokine production in patients with sepsis , severe sepsis , and septic_shock .
17521621	0	TLR2	0,4	TLR4	26,30	TLR2	TLR4	24088(Tax:10090)	21898(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus_pneumoniae .
19895846	0	TLR2	0,4	TLR4	7,11	TLR2	TLR4	24088(Tax:10090)	21898(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|amod|END_ENTITY	TLR2 - , TLR4 - and Myd88-independent acquired humoral and cellular immunity against Salmonella_enterica_serovar_Typhimurium .
19915052	0	TLR2	0,4	TLR4	37,41	TLR2	TLR4	7097	7099	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|responses responses|nmod|END_ENTITY	TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop .
20596831	0	TLR2	23,27	TLR4	0,4	TLR2	TLR4	7097	7099	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TLR4 signaling induced TLR2 expression in the process of mimic cerebral_ischemia / reperfusion in vitro .
21050341	0	TLR2	8,12	TLR4	15,19	TLR2	TLR4	7097	7099	Gene	Gene	_|nsubj|START_ENTITY _|dobj|correlates correlates|nummod|END_ENTITY	Hepatic TLR2 _ TLR4 expression correlates with hepatic_inflammation and TNF-a in HCV _ HCV/HIV _ infection .
16365150	0	TLR2	49,53	TLR9	0,4	TLR2	TLR9	24088(Tax:10090)	81897(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium_tuberculosis .
24023674	0	TLR2	0,4	TLR9	92,96	TLR2	TLR9	24088(Tax:10090)	81897(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|recruitment recruitment|nmod|contributions contributions|nmod|END_ENTITY	TLR2 regulates neutrophil recruitment and cytokine production with minor contributions from TLR9 during hypersensitivity pneumonitis .
15792558	0	TLR2	28,32	TNF	50,53	TLR2	TNF	24088(Tax:10090)	21926(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nsubj|modulation	-LSB- Differential modulation of TLR2 and TLR4-induced TNF production by murin haemorrhagic_shock -RSB- .
16480927	0	TLR2	24,28	TNF_alpha	0,9	TLR2	TNF alpha	7097	7124	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	TNF_alpha production to TLR2 ligands in active IBD patients .
25385819	0	TLR2	21,25	TRAM	0,4	TLR2	TRAM	7097	353376	Gene	Gene	Signaling|compound|START_ENTITY Required|nmod|Signaling Required|nsubjpass|END_ENTITY	TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction .
16283346	0	TLR2	22,26	Toll-like_receptor_2	0,20	TLR2	Toll-like receptor 2	7097	7097	Gene	Gene	mediates|appos|START_ENTITY mediates|amod|END_ENTITY	Toll-like_receptor_2 -LRB- TLR2 -RRB- mediates intracellular signalling in human keratinocytes in response to Malassezia furfur .
23279536	0	TLR2	42,46	Toll-like_receptor_2	20,40	TLR2	Toll-like receptor 2	448807(Tax:9615)	448807(Tax:9615)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	The localization of Toll-like_receptor_2 -LRB- TLR2 -RRB- in the endometrium and the cervix of dogs at different stages of the oestrous cycle and with pyometra .
16888154	0	TLR2	17,21	VIP	10,13	TLR2	VIP	24088(Tax:10090)	22353(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS-induced colitis .
19124728	0	TLR2	57,61	dUTPase	16,23	TLR2	dUTPase	7097	34529(Tax:7227)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	The EBV-encoded dUTPase activates NF-kappa_B through the TLR2 and MyD88-dependent signaling pathway .
24043886	0	TLR2	20,24	gp120	6,11	TLR2	gp120	7097	3700	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	HIV-1 gp120 induces TLR2 - and TLR4-mediated innate immune activation in human female genital epithelium .
23082910	0	TLR2	30,34	lysozyme	106,114	TLR2	lysozyme	100860747	100860864	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of over-expression of TLR2 in transgenic goats on pathogen clearance and role of up-regulation of lysozyme secretion and infiltration of inflammatory cells .
26722463	0	TLR2	23,27	miR-143	0,7	TLR2	miR-143	7097	406935	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	miR-143 down-regulates TLR2 expression in hepatoma cells and inhibits hepatoma cell proliferation and invasion .
22330023	0	TLR2	0,4	p38_MAPK	23,31	TLR2	p38 MAPK	24088(Tax:10090)	26416(Tax:10090)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	TLR2 and TLR4 activate p38_MAPK and JNK during endurance exercise in skeletal muscle .
18566366	0	TLR2	14,18	serum_amyloid_A	60,75	TLR2	serum amyloid A	7097	6287	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Cutting edge : TLR2 is a functional receptor for acute-phase serum_amyloid_A .
15190028	0	TLR2	67,71	toll-like_receptor_2	45,65	TLR2	toll-like receptor 2	7097	7097	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	The glycopeptide vancomycin does not enhance toll-like_receptor_2 -LRB- TLR2 -RRB- activation by Streptococcus_pneumoniae .
18096121	0	TLR2	36,40	toll-like_receptor_2	14,34	TLR2	toll-like receptor 2	24088(Tax:10090)	24088(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of toll-like_receptor_2 -LRB- TLR2 -RRB- in porcine leukocyte subsets and tissues .
25180613	0	TLR2	61,65	toll-like_receptor_2	39,59	TLR2	toll-like receptor 2	7097	7097	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphisms in the toll-like_receptor_2 -LRB- TLR2 -RRB- gene are associated with microscopic_polyangiitis in the northern Han Chinese population .
22114704	0	TLR2/1	19,25	IL1b	35,39	TLR2/1	IL1b	24088;21897	16176(Tax:10090)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|expression expression|amod|END_ENTITY	Nod2 downregulates TLR2/1 mediated IL1b gene expression in mouse peritoneal macrophages .
24875140	0	TLR2/4	109,115	ICAM-1	43,49	TLR2/4	ICAM-1	7097;7099	3383	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway .
21829704	0	TLR2/4	30,36	TIRAP	0,5	TLR2/4	TIRAP	7097;7099	114609	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	TIRAP , an adaptor protein for TLR2/4 , transduces a signal from RAGE phosphorylated upon ligand binding .
24875140	0	TLR2/4	109,115	biglycan	8,16	TLR2/4	biglycan	7097;7099	633	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway .
20471186	0	TLR21	15,20	interleukin-12	44,58	TLR21	interleukin-12	415623(Tax:9031)	404671(Tax:9031)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of TLR21 in baculovirus-induced interleukin-12 gene expression in avian macrophage-like cell line HD11 .
23365087	0	TLR3	14,18	ADAM15	65,71	TLR3	ADAM15	7098	8751	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	TRIF-mediated TLR3 and TLR4 signaling is negatively regulated by ADAM15 .
26536229	0	TLR3	110,114	CCL20	124,129	TLR3	CCL20	7098	6364	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory_Bowel_Disease , and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells .
20523058	0	TLR3	45,49	CCL5	26,30	TLR3	CCL5	7098	6352	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Cooperative activation of CCL5 expression by TLR3 and tumor_necrosis_factor-alpha or interferon-gamma through nuclear factor-kappaB or STAT-1 in airway epithelial cells .
22147891	0	TLR3	0,4	CD8	63,66	TLR3	CD8	7098	925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|responses responses|compound|END_ENTITY	TLR3 essentially promotes protective class I-restricted memory CD8 T-cell responses to Aspergillus_fumigatus in hematopoietic transplanted patients .
24462705	0	TLR3	0,4	IL-10	41,46	TLR3	IL-10	142980(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway .
22762377	0	TLR3	63,67	IL-8	28,32	TLR3	IL-8	7098	3576	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes .
24630834	0	TLR3	31,35	ISG54	0,5	TLR3	ISG54	7098	3433	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	ISG54 and ISG56 are induced by TLR3 signaling in U373MG human astrocytoma cells : possible involvement in CXCL10 expression .
25822580	0	TLR3	26,30	Interferon-Gamma	0,16	TLR3	Interferon-Gamma	7098	3458	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Interferon-Gamma Enhances TLR3 Expression and Anti-Viral Activity in Keratinocytes .
26405273	0	TLR3	59,63	Toll	11,15	TLR3	Toll	7098	7099	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|dep|Role	Paying the Toll for Glucose Regulation : A Central Role for TLR3 .
25264029	0	TLR3	70,74	Toll-Like_Receptor_3	48,68	TLR3	Toll-Like Receptor 3	142980(Tax:10090)	142980(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel protective role for the innate immunity Toll-Like_Receptor_3 -LRB- TLR3 -RRB- in the retina via Stat3 .
21216866	0	TLR3	40,44	Toll-like_receptor_3	13,33	TLR3	Toll-like receptor 3	7098	7098	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A functional Toll-like_receptor_3 gene -LRB- TLR3 -RRB- may be a risk factor for tick-borne_encephalitis_virus _ -LRB- TBEV -RRB- _ infection .
21911501	0	TLR3	22,26	Toll-like_receptor_3	0,20	TLR3	Toll-like receptor 3	7098	7098	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Toll-like_receptor_3 -LRB- TLR3 -RRB- signaling requires TLR4_Interactor_with_leucine-rich_REPeats -LRB- TRIL -RRB- .
23716670	0	TLR3	22,26	Toll-like_receptor_3	0,20	TLR3	Toll-like receptor 3	7098	7098	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Toll-like_receptor_3 -LRB- TLR3 -RRB- activation induces microRNA-dependent reexpression of functional RARb and tumor regression .
26979086	0	TLR3	88,92	p53	111,114	TLR3	p53	7098	7157	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Moraxella_catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells .
17617600	0	TLR3	0,4	thymic_stromal_lymphopoietin	47,75	TLR3	thymic stromal lymphopoietin	7098	85480	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	TLR3 - and Th2 cytokine-dependent production of thymic_stromal_lymphopoietin in human airway epithelial cells .
21691053	0	TLR3	145,149	thymic_stromal_lymphopoietin	34,62	TLR3	thymic stromal lymphopoietin	7098	85480	Gene	Gene	role|nmod|START_ENTITY epithelium|dep|role trigger|nmod|epithelium trigger|dobj|expression expression|compound|END_ENTITY	Viral stimuli trigger exaggerated thymic_stromal_lymphopoietin expression by chronic_obstructive_pulmonary_disease epithelium : role of endosomal TLR3 and cytosolic RIG-I-like helicases .
20511545	0	TLR4	0,4	67-kDa_laminin_receptor	101,124	TLR4	67-kDa laminin receptor	7099	3921	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|tea tea|amod|polyphenol_epigallocatechin-3-gallate polyphenol_epigallocatechin-3-gallate|advcl|END_ENTITY	TLR4 signaling inhibitory pathway induced by green tea polyphenol_epigallocatechin-3-gallate through 67-kDa_laminin_receptor .
22960171	0	TLR4	57,61	67-kDa_laminin_receptor	84,107	TLR4	67-kDa laminin receptor	7099	3921	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Green tea polyphenol_epigallocatechin-3-gallate inhibits TLR4 signaling through the 67-kDa_laminin_receptor on lipopolysaccharide-stimulated dendritic cells .
25109435	0	TLR4	111,115	67-kDa_laminin_receptor	65,88	TLR4	67-kDa laminin receptor	7099	3921	Gene	Gene	regulating|dobj|START_ENTITY negatively|acl|regulating negatively|amod|END_ENTITY	Epigallocatechin-3-gallate-mediated Tollip induction through the 67-kDa_laminin_receptor negatively regulating TLR4 signaling in endothelial cells .
19740331	0	TLR4	119,123	Astrocyte_elevated_gene-1	0,25	TLR4	Astrocyte elevated gene-1	7099	92140	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- is induced by lipopolysaccharide as toll-like_receptor_4 -LRB- TLR4 -RRB- ligand and regulates TLR4 signalling .
19740331	0	TLR4	92,96	Astrocyte_elevated_gene-1	0,25	TLR4	Astrocyte elevated gene-1	7099	92140	Gene	Gene	TLR4|appos|START_ENTITY induced|nmod|TLR4 induced|nsubjpass|END_ENTITY	Astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- is induced by lipopolysaccharide as toll-like_receptor_4 -LRB- TLR4 -RRB- ligand and regulates TLR4 signalling .
21325271	3	TLR4	530,534	BMP-2	552,557	TLR4	BMP-2	7099	650	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The aim of this study was to determine the effect of oxidized low density lipoprotein -LRB- oxLDL -RRB- on BMP-2 protein expression in human coronary artery endothelial cells -LRB- CAECs -RRB- , the roles of Toll-like receptor -LRB- TLR -RRB- 2 and TLR4 in oxLDL-induced BMP-2 expression , and the signaling pathways involved .
11274165	1	TLR4	121,125	CD14	113,117	TLR4	CD14	7099	929	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	transfer from CD14 to TLR4 and MD-2 .
19574428	0	TLR4	96,100	CD19	0,4	TLR4	CD19	21898(Tax:10090)	12478(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nmod|signaling regulates|nsubj|END_ENTITY	CD19 , a response regulator of B lymphocytes , regulates wound healing through hyaluronan-induced TLR4 signaling .
23086480	0	TLR4	131,135	CX3CR1	110,116	TLR4	CX3CR1	7099	1524	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Inflammatory effects of resistin on human smooth_muscle_cells : up-regulation of fractalkine and its receptor , CX3CR1 expression by TLR4 and Gi-protein pathways .
16424218	0	TLR4	75,79	Corticotropin-releasing_factor	0,30	TLR4	Corticotropin-releasing factor	21898(Tax:10090)	12918(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Corticotropin-releasing_factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU .1 and AP-1 .
20732324	0	TLR4	41,45	Corticotropin-releasing_factor	0,30	TLR4	Corticotropin-releasing factor	21898(Tax:10090)	12918(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Corticotropin-releasing_factor regulates TLR4 expression in the colon and protects mice from colitis .
26466961	0	TLR4	87,91	FAK	134,137	TLR4	FAK	21898(Tax:10090)	14083(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88 .
22002164	0	TLR4	16,20	GLA	30,33	TLR4	GLA	21898(Tax:10090)	11605(Tax:10090)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	A new synthetic TLR4 agonist , GLA , allows dendritic cells targeted with antigen to elicit Th1 T-cell immunity in vivo .
23677465	0	TLR4	46,50	Glia_maturation_factor-y	0,24	TLR4	Glia maturation factor-y	7099	9535	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Glia_maturation_factor-y negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages .
23677465	0	TLR4	77,81	Glia_maturation_factor-y	0,24	TLR4	Glia maturation factor-y	7099	9535	Gene	Gene	trafficking|nummod|START_ENTITY facilitating|dobj|trafficking signaling|advcl|facilitating TLR4|acl|signaling modulates|dobj|TLR4 modulates|nsubj|END_ENTITY	Glia_maturation_factor-y negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages .
20660289	0	TLR4	54,58	Granulysin	0,10	TLR4	Granulysin	7099	10578	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Granulysin activates antigen-presenting_cells through TLR4 and acts as an immune alarmin .
21622863	0	TLR4	44,48	Group_X_secretory_phospholipase_A2	0,34	TLR4	Group X secretory phospholipase A2	21898(Tax:10090)	26565(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Group_X_secretory_phospholipase_A2 enhances TLR4 signaling in macrophages .
23185615	0	TLR4	67,71	HIF-1a	96,102	TLR4	HIF-1a	21898(Tax:10090)	15251(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Peroxiredoxin_1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1a .
23148306	0	TLR4	0,4	HMGB1	21,26	TLR4	HMGB1	7099	3146	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	TLR4 as receptor for HMGB1 induced muscle_dysfunction in myositis .
19124725	0	TLR4	0,4	IFN-alpha	20,29	TLR4	IFN-alpha	21898(Tax:10090)	111654(Tax:10090)	Gene	Gene	ligands|nsubj|START_ENTITY ligands|xcomp|induce induce|dobj|production production|amod|END_ENTITY	TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming .
24489101	0	TLR4	103,107	IL-1b	82,87	TLR4	IL-1b	7099	3553	Gene	Gene	stimulation|compound|START_ENTITY produce|nmod|stimulation produce|dobj|END_ENTITY	Cutting edge : Endoplasmic reticulum stress licenses macrophages to produce mature IL-1b in response to TLR4 stimulation through a caspase-8 - _ and_TRIF-dependent pathway .
18343502	0	TLR4	99,103	IL-6	36,40	TLR4	IL-6	7099	3569	Gene	Gene	expression|compound|START_ENTITY cells|nmod|expression production|nmod|cells production|nsubj|END_ENTITY	Rapamycin suppresses TLR4-triggered IL-6 and PGE -LRB- 2 -RRB- production of colon_cancer cells by inhibiting TLR4 expression and NF-kappaB activation .
22030478	0	TLR4	16,20	IL-6	72,76	TLR4	IL-6	7099	3569	Gene	Gene	Coactivation|nmod|START_ENTITY coordinates|nsubj|Coactivation coordinates|nmod|transcription transcription|compound|END_ENTITY	Coactivation of TLR4 and TLR2/6 coordinates an additive augmentation on IL-6 gene transcription via p38MAPK pathway in U937 mononuclear cells .
22934260	0	TLR4	0,4	IL-6	104,108	TLR4	IL-6	7099	3569	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling induces|nmod|cells cells|acl:relcl|regulate regulate|dobj|END_ENTITY	TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA_let-7b .
27091427	0	TLR4	0,4	IL-6	27,31	TLR4	IL-6	21898(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	TLR4 induces CREB-mediated IL-6 production via upregulation of F-spondin to promote vascular smooth muscle cell migration .
24971461	0	TLR4	54,58	IL10	109,113	TLR4	IL10	7099	3586	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
24971461	0	TLR4	54,58	IL23R	115,120	TLR4	IL23R	7099	149233	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
24971461	0	TLR4	54,58	IL6R	103,107	TLR4	IL6R	7099	3570	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
16266460	4	TLR4	713,717	LOX-1	719,724	TLR4	LOX-1	7099	4973	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	METHODS : HUVECs were incubated with purified LPS for 24 h. TLR4 , LOX-1 , ICAM-1 , E-selectin mRNA were measured by RT-PCR ; the protein expression of TLR4 , LOX-1 and activation of NF-kappaB were detected by Western blot ; the adhesive percentage between HUVECs and monocytes was determined by direct counting .
24615033	5	TLR4	1076,1080	LOX-1	1082,1087	TLR4	LOX-1	7099	4973	Gene	Gene	MCP-1|compound|START_ENTITY MCP-1|appos|END_ENTITY	After 48 h of processing HUVECs with pyrrolidine_dithiocarbamate -LRB- PDTC -RRB- , protein expressions of TLR4 , LOX-1 , MCP-1 , and VCAM - _ 1 were detected by Western blot .
24971461	0	TLR4	54,58	LY96	66,70	TLR4	LY96	7099	23643	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
21677444	0	TLR4	6,10	MCP-1	63,68	TLR4	MCP-1	7099	6347	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-b in patients with chronic_kidney_disease .
12496426	0	TLR4	193,197	MD-2	24,28	TLR4	MD-2	21898(Tax:10090)	17087(Tax:10090)	Gene	Gene	recognized|nmod|START_ENTITY recognized|nsubj|Identification Identification|nmod|residues residues|compound|END_ENTITY	Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies , and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis .
15184344	0	TLR4	128,132	MD-2	104,108	TLR4	MD-2	7099	23643	Gene	Gene	oligomerization|compound|START_ENTITY oligomerization|compound|END_ENTITY	Lipid_A antagonist , lipid IVa , is distinct from lipid_A in interaction with Toll-like_receptor_4 -LRB- TLR4 -RRB- - MD-2 and ligand-induced TLR4 oligomerization .
15184344	0	TLR4	98,102	MD-2	104,108	TLR4	MD-2	7099	23643	Gene	Gene	Toll-like_receptor_4|appos|START_ENTITY Toll-like_receptor_4|dep|oligomerization oligomerization|compound|END_ENTITY	Lipid_A antagonist , lipid IVa , is distinct from lipid_A in interaction with Toll-like_receptor_4 -LRB- TLR4 -RRB- - MD-2 and ligand-induced TLR4 oligomerization .
15557191	0	TLR4	57,61	MD-2	74,78	TLR4	MD-2	29260(Tax:10116)	23643	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling .
16272300	0	TLR4	79,83	MD-2	96,100	TLR4	MD-2	7099	23643	Gene	Gene	coreceptor|compound|START_ENTITY coreceptor|appos|END_ENTITY	Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor , MD-2 .
16946018	0	TLR4	84,88	MD-2	0,4	TLR4	MD-2	7099	23643	Gene	Gene	Toll-like_receptor_4|appos|START_ENTITY targeting|nmod|Toll-like_receptor_4 surface|acl|targeting required|nmod|surface required|nsubjpass|expression expression|compound|END_ENTITY	MD-2 expression is not required for cell surface targeting of Toll-like_receptor_4 -LRB- TLR4 -RRB- .
17217428	0	TLR4	84,88	MD-2	120,124	TLR4	MD-2	7099	23643	Gene	Gene	block|nmod|START_ENTITY block|nmod|site site|compound|END_ENTITY	Antagonistic lipopolysaccharides block E. _ coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site .
17545685	0	TLR4	80,84	MD-2	6,10	TLR4	MD-2	7099	23643	Gene	Gene	discrimination|nmod|START_ENTITY discrimination|compound|END_ENTITY	Human MD-2 discrimination of meningococcal lipid_A structures and activation of TLR4 .
18203953	0	TLR4	90,94	MD-2	42,46	TLR4	MD-2	21898(Tax:10090)	17087(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY depend|nmod|signaling opsonized|ccomp|depend opsonized|nsubj|Phagocytosis Phagocytosis|nmod|END_ENTITY	Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling .
18424732	0	TLR4	167,171	MD-2	23,27	TLR4	MD-2	7099	23643	Gene	Gene	ectodomain|compound|START_ENTITY endotoxin|nmod|ectodomain forms|dep|endotoxin different|nmod|forms different|nsubj|activity activity|nmod|variant variant|compound|END_ENTITY	Functional activity of MD-2 polymorphic variant is significantly different in soluble and TLR4-bound forms : decreased endotoxin binding by G56R MD-2 and its rescue by TLR4 ectodomain .
18977229	0	TLR4	22,26	MD-2	51,55	TLR4	MD-2	7099	23643	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Taxanes inhibit human TLR4 signaling by binding to MD-2 .
20212095	0	TLR4	122,126	MD-2	97,101	TLR4	MD-2	7099	23643	Gene	Gene	does|dobj|START_ENTITY depends|advcl|does depends|nmod|coexpression coexpression|nmod|END_ENTITY	Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4 .
20212095	0	TLR4	60,64	MD-2	97,101	TLR4	MD-2	7099	23643	Gene	Gene	variant|nmod|START_ENTITY Expression|nmod|variant depends|nsubj|Expression depends|nmod|coexpression coexpression|nmod|END_ENTITY	Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4 .
20435923	0	TLR4	105,109	MD-2	32,36	TLR4	MD-2	7099	23643	Gene	Gene	regulates|dobj|START_ENTITY variant|acl:relcl|regulates splice|dobj|variant splice|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling .
21402551	0	TLR4	83,87	MD-2	0,4	TLR4	MD-2	7099	23643	Gene	Gene	activity|compound|START_ENTITY inhibition|nmod|activity chalcone|nmod|inhibition chalcone|nsubj|END_ENTITY	MD-2 as the target of nonlipid chalcone in the inhibition of endotoxin LPS-induced TLR4 activity .
23439691	0	TLR4	100,104	MD-2	33,37	TLR4	MD-2	7099	23643	Gene	Gene	generates|nmod|START_ENTITY generates|nsubj|Radioiodination Radioiodination|nmod|complex complex|compound|END_ENTITY	Radioiodination of an endotoxin MD-2 complex generates a novel sensitive , high-affinity ligand for TLR4 .
24688705	0	TLR4	74,78	MD-2	81,85	TLR4	MD-2	100066890(Tax:9796)	23643	Gene	Gene	amino_acids|nmod|START_ENTITY Reviewing|dobj|amino_acids complexes|dep|Reviewing complexes|compound|END_ENTITY	Reviewing and identifying amino_acids of human , murine , canine and equine TLR4 / MD-2 receptor complexes conferring endotoxic innate immunity activation by LPS/lipid _ A , or antagonistic effects by Eritoran , in contrast to species-dependent modulation by lipid IVa .
25037631	0	TLR4	91,95	MD-2	86,90	TLR4	MD-2	7099	17087(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The molecular mechanism of species-specific recognition of lipopolysaccharides by the MD-2 / TLR4 receptor complex .
25203747	0	TLR4	31,35	MD-2	98,102	TLR4	MD-2	21898(Tax:10090)	17087(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY governed|nsubj|activation governed|nmod|residues residues|nmod|END_ENTITY	Species-specific activation of TLR4 by hypoacylated endotoxins governed by residues 82 and 122 of MD-2 .
25394365	0	TLR4	61,65	MD-2	55,59	TLR4	MD-2	7099	23643	Gene	Gene	antagonism|compound|START_ENTITY antagonism|compound|END_ENTITY	Anti-endotoxic activity and structural basis for human MD-2 TLR4 antagonism of tetraacylated_lipid_A mimetics based on bGlcN -LRB- 1 1 -RRB- aGlcN scaffold .
25559892	0	TLR4	47,51	MD-2	0,4	TLR4	MD-2	21898(Tax:10090)	17087(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nmod|signaling required|nsubjpass|END_ENTITY	MD-2 is required for disulfide HMGB1-dependent TLR4 signaling .
25803856	0	TLR4	68,72	MD-2	0,4	TLR4	MD-2	7099	23643	Gene	Gene	Determinants|nmod|START_ENTITY Determinants|compound|END_ENTITY	MD-2 Determinants of Nickel and Cobalt-Mediated Activation of Human TLR4 .
26160169	0	TLR4	42,46	MD-2	83,87	TLR4	MD-2	7099	23643	Gene	Gene	Myeloid_Differentiation_Factor_2|appos|START_ENTITY Myeloid_Differentiation_Factor_2|appos|END_ENTITY	Activation of Human Toll-like_Receptor_4 -LRB- TLR4 -RRB- Myeloid_Differentiation_Factor_2 -LRB- MD-2 -RRB- by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia_cenocepacia .
26330549	0	TLR4	46,50	MD-2	17,21	TLR4	MD-2	21898(Tax:10090)	17087(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	Gedunin Binds to MD-2 and Impairs LPS-Induced TLR4 Signaling in Macrophages .
18845299	0	TLR4	22,26	MD2	8,11	TLR4	MD2	7099	23643	Gene	Gene	levels|nummod|START_ENTITY increases|dobj|levels increases|nsubj|END_ENTITY	Soluble MD2 increases TLR4 levels on the epithelial cell surface .
22485159	0	TLR4	79,83	Mal	72,75	TLR4	Mal	7099	4118	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling .
18566426	0	TLR4	55,59	MyD88	0,5	TLR4	MyD88	21898(Tax:10090)	17874(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY dependent|nsubj|regulation regulation|amod|END_ENTITY	MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2 .
19506249	0	TLR4	74,78	MyD88	54,59	TLR4	MyD88	7099	4615	Gene	Gene	signaling|compound|START_ENTITY basis|nmod|signaling basis|nmod|interactions interactions|nmod|domain domain|compound|END_ENTITY	Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling .
21498664	0	TLR4	0,4	MyD88	19,24	TLR4	MyD88	21898(Tax:10090)	17874(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	TLR4 signaling via MyD88 and TRIF differentially shape the CD4 + T cell response to Porphyromonas_gingivalis_hemagglutinin_B .
21897371	0	TLR4	95,99	MyD88	86,91	TLR4	MyD88	7099	4615	Gene	Gene	signalling|compound|START_ENTITY END_ENTITY|nmod|signalling	Smad6-specific recruitment of Smurf E3 ligases mediates TGF-b1-induced degradation of MyD88 in TLR4 signalling .
22394636	0	TLR4	36,40	MyD88	42,47	TLR4	MyD88	21898(Tax:10090)	17874(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The expression and significance of TLR4 , MyD88 and NF-kB mRNA in mouse lymph node of experimental autoimmune_myositis -RSB- .
22474023	0	TLR4	34,38	MyD88	84,89	TLR4	MyD88	7099	4615	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|interfering interfering|nmod|recruitment recruitment|nmod|END_ENTITY	The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF .
22788664	0	TLR4	36,40	MyD88	42,47	TLR4	MyD88	7099	4615	Gene	Gene	NF-kappaB|nummod|START_ENTITY NF-kappaB|dep|END_ENTITY	LPS induces IL-8 expression through TLR4 , MyD88 , NF-kappaB and MAPK pathways in human dental pulp stem cells .
23716300	0	TLR4	94,98	MyD88	0,5	TLR4	MyD88	21898(Tax:10090)	17874(Tax:10090)	Gene	Gene	adjuvant|compound|START_ENTITY required|nmod|adjuvant required|nsubjpass|interaction interaction|amod|END_ENTITY	MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant .
26043978	0	TLR4	63,67	MyD88	150,155	TLR4	MyD88	7099	4615	Gene	Gene	responsiveness|nummod|START_ENTITY responsiveness|acl:relcl|associated associated|nmod|expression expression|compound|END_ENTITY	Bovine_viral_diarrhea_virus_type_2 in vivo infection modulates TLR4 responsiveness in differentiated myeloid cells which is associated with decreased MyD88 expression .
26175492	0	TLR4	99,103	MyD88	68,73	TLR4	MyD88	7099	4615	Gene	Gene	activation|compound|START_ENTITY conferred|nmod|activation conferred|nmod|pathways pathways|compound|END_ENTITY	Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation .
15567069	0	TLR4	32,36	NF-kappaB	70,79	TLR4	NF-kappaB	7099	4790	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB .
24971461	0	TLR4	54,58	NFKB1	80,85	TLR4	NFKB1	7099	4790	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
24971461	0	TLR4	54,58	NFKBIA	72,78	TLR4	NFKBIA	7099	4792	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
16757890	0	TLR4	39,43	NOD1	17,21	TLR4	NOD1	21898(Tax:10090)	107607(Tax:10090)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages .
19946272	0	TLR4	23,27	PDCD4	82,87	TLR4	PDCD4	7099	27250	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 .
20018613	0	TLR4	80,84	Peroxiredoxin_1	0,15	TLR4	Peroxiredoxin 1	21898(Tax:10090)	18477(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Peroxiredoxin_1 stimulates secretion of proinflammatory cytokines by binding to TLR4 .
20643919	0	TLR4	38,42	Rab10	20,25	TLR4	Rab10	7099	10890	Gene	Gene	facilitates|dobj|START_ENTITY facilitates|nsubj|END_ENTITY	Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane .
17395780	0	TLR4	132,136	Rab7b	37,42	TLR4	Rab7b	7099	338382	Gene	Gene	degradation|nmod|START_ENTITY promoting|dobj|degradation signaling|advcl|promoting TLR4|acl|signaling regulates|dobj|TLR4 regulates|nsubj|END_ENTITY	Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4 .
17395780	0	TLR4	64,68	Rab7b	37,42	TLR4	Rab7b	7099	338382	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4 .
22470535	0	TLR4	24,28	S100A9	0,6	TLR4	S100A9	21898(Tax:10090)	20202(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	S100A9 interaction with TLR4 promotes tumor growth .
21151968	0	TLR4	0,4	STAT3	42,47	TLR4	STAT3	29260(Tax:10116)	25125(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|cell cell|amod|activation activation|advmod|END_ENTITY	TLR4 inhibits mesenchymal stem cell -LRB- MSC -RRB- STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection .
25595264	0	TLR4	11,15	STAT3	68,73	TLR4	STAT3	21898(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain .
26299839	0	TLR4	23,27	STAT3	113,118	TLR4	STAT3	21898(Tax:10090)	20848(Tax:10090)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|dependent dependent|nmod|END_ENTITY	Angiotensin_II-induced TLR4 mediated abdominal_aortic_aneurysm in apolipoprotein_E knockout mice is dependent on STAT3 .
26582088	0	TLR4	0,4	STAT3	41,46	TLR4	STAT3	21898(Tax:10090)	20848(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Cooperates Cooperates|nmod|END_ENTITY	TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice .
16754682	0	TLR4	45,49	Surfactant_protein_A	0,20	TLR4	Surfactant protein A	7099	653509	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Surfactant_protein_A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response .
18234474	0	TLR4	51,55	Syntenin	0,8	TLR4	Syntenin	7099	6386	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Syntenin negatively regulates TRAF6-mediated IL-1R / TLR4 signaling .
24211974	0	TLR4	0,4	TGF-b1	83,89	TLR4	TGF-b1	21898(Tax:10090)	21803(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	TLR4 signaling pathway in mouse Lewis lung_cancer cells promotes the expression of TGF-b1 and IL-10 and tumor cells migration .
11502220	0	TLR4	118,122	TLR2	141,145	TLR4	TLR2	7099	7097	Gene	Gene	Reconstitution|compound|START_ENTITY Reconstitution|nmod|END_ENTITY	Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor -LRB- TLR -RRB- 2 as well as TLR4 Reconstitution of TLR2 - and TLR4-activation by distinguishable ligands in LPS preparations .
14561708	0	TLR4	0,4	TLR2	23,27	TLR4	TLR2	21898(Tax:10090)	24088(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY induces|nsubj|signaling induces|dobj|expression expression|nummod|END_ENTITY	TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase .
15349893	0	TLR4	43,47	TLR2	54,58	TLR4	TLR2	7099	7097	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|END_ENTITY	Selective priming to Toll-like receptor 4 -LRB- TLR4 -RRB- , not TLR2 , ligands by P. _ acnes involves up-regulation of MD-2 in mice .
15585882	0	TLR4	130,134	TLR2	30,34	TLR4	TLR2	7099	7097	Gene	Gene	induced|nmod|START_ENTITY induction|acl:relcl|induced released|dobj|induction released|nmod|blocks blocks|compound|END_ENTITY	IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells .
16272176	0	TLR4	48,52	TLR2	71,75	TLR4	TLR2	21898(Tax:10090)	24088(Tax:10090)	Gene	Gene	upregulation|nummod|START_ENTITY upregulation|compound|END_ENTITY	Hemorrhagic_shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages : role in hemorrhage-primed_lung_inflammation .
16604477	0	TLR4	108,112	TLR2	102,106	TLR4	TLR2	399541(Tax:9823)	101055400	Gene	Gene	TLR5|appos|START_ENTITY TLR5|compound|END_ENTITY	Biased distribution of single nucleotide polymorphisms -LRB- SNPs -RRB- in porcine Toll-like_receptor_1 -LRB- TLR1 -RRB- , TLR2 , TLR4 , TLR5 , and TLR6 genes .
16670636	0	TLR4	6,10	TLR2	0,4	TLR4	TLR2	7099	7097	Gene	Gene	CD11B|appos|START_ENTITY CD11B|compound|END_ENTITY	TLR2 , TLR4 , CD14 , CD11B , and CD11C expressions on monocytes surface and cytokine production in patients with sepsis , severe sepsis , and septic_shock .
17521621	0	TLR4	26,30	TLR2	0,4	TLR4	TLR2	21898(Tax:10090)	24088(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus_pneumoniae .
19895846	0	TLR4	7,11	TLR2	0,4	TLR4	TLR2	21898(Tax:10090)	24088(Tax:10090)	Gene	Gene	-|amod|START_ENTITY -|compound|END_ENTITY	TLR2 - , TLR4 - and Myd88-independent acquired humoral and cellular immunity against Salmonella_enterica_serovar_Typhimurium .
19915052	0	TLR4	37,41	TLR2	0,4	TLR4	TLR2	7099	7097	Gene	Gene	responses|nmod|START_ENTITY promotes|dobj|responses promotes|nsubj|END_ENTITY	TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop .
20596831	0	TLR4	0,4	TLR2	23,27	TLR4	TLR2	7099	7097	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TLR4 signaling induced TLR2 expression in the process of mimic cerebral_ischemia / reperfusion in vitro .
21050341	0	TLR4	15,19	TLR2	8,12	TLR4	TLR2	7099	7097	Gene	Gene	correlates|nummod|START_ENTITY _|dobj|correlates _|nsubj|END_ENTITY	Hepatic TLR2 _ TLR4 expression correlates with hepatic_inflammation and TNF-a in HCV _ HCV/HIV _ infection .
15184344	0	TLR4	128,132	TLR4	98,102	TLR4	TLR4	7099	7099	Gene	Gene	oligomerization|compound|START_ENTITY Toll-like_receptor_4|dep|oligomerization Toll-like_receptor_4|appos|END_ENTITY	Lipid_A antagonist , lipid IVa , is distinct from lipid_A in interaction with Toll-like_receptor_4 -LRB- TLR4 -RRB- - MD-2 and ligand-induced TLR4 oligomerization .
15184344	0	TLR4	98,102	TLR4	128,132	TLR4	TLR4	7099	7099	Gene	Gene	Toll-like_receptor_4|appos|START_ENTITY Toll-like_receptor_4|dep|oligomerization oligomerization|compound|END_ENTITY	Lipid_A antagonist , lipid IVa , is distinct from lipid_A in interaction with Toll-like_receptor_4 -LRB- TLR4 -RRB- - MD-2 and ligand-induced TLR4 oligomerization .
22414145	0	TLR4	0,4	TLR4	132,136	TLR4	TLR4	7099	7099	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	TLR4 , IL-6 , IL-18 , MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6 .
22414145	0	TLR4	132,136	TLR4	0,4	TLR4	TLR4	7099	7099	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	TLR4 , IL-6 , IL-18 , MyD88 and HMGB1 are highly expressed in intracranial inflammatory lesions and the IgG4/IgG ratio correlates with TLR4 and IL-6 .
17599410	0	TLR4	21,25	TLR9	0,4	TLR4	TLR9	21898(Tax:10090)	81897(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells .
24121213	0	TLR4	133,137	TLR9	6,10	TLR4	TLR9	7099	54106	Gene	Gene	genes|compound|START_ENTITY polymorphisms|nmod|genes aGVHD|nmod|polymorphisms influence|xcomp|aGVHD influence|nsubj|tagSNPs tagSNPs|compound|END_ENTITY	Donor TLR9 gene tagSNPs influence susceptibility to aGVHD and CMV reactivation in the allo-HSCT setting without polymorphisms in the TLR4 and NOD2 genes .
24971461	0	TLR4	54,58	TLR9	60,64	TLR4	TLR9	7099	54106	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
17507094	0	TLR4	15,19	TNF-receptor-associated-factor-6	73,105	TLR4	TNF-receptor-associated-factor-6	21898(Tax:10090)	22034(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Sensitivity of TLR4 - and -7 - induced NF_kappa_B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages .
24971461	0	TLR4	54,58	TNFA	87,91	TLR4	TNFA	7099	7124	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
24971461	0	TLR4	54,58	TNFRSF1A	93,101	TLR4	TNFRSF1A	7099	7132	Gene	Gene	PTPN22|compound|START_ENTITY PTPN22|appos|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
22450316	0	TLR4	36,40	TNFa	0,4	TLR4	TNFa	7099	7124	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	TNFa and IL-1b are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS .
25825441	0	TLR4	57,61	TRAM	91,95	TLR4	TRAM	7099	353376	Gene	Gene	Pathway|compound|START_ENTITY Pathway|nmod|END_ENTITY	Phosphatase PTPN4 Preferentially Inhibits TRIF-Dependent TLR4 Pathway by Dephosphorylating TRAM .
21393555	0	TLR4	39,43	TRPV1	15,20	TLR4	TRPV1	7099	7442	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons .
25139109	0	TLR4	0,4	TRPV1	58,63	TLR4	TRPV1	7099	7442	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|potentiating potentiating|dobj|activity activity|compound|END_ENTITY	TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity .
26424893	0	TLR4	117,121	TRPV1	94,99	TLR4	TRPV1	7099	7442	Gene	Gene	Activation|nmod|START_ENTITY Responses|nmod|Activation Responses|nmod|END_ENTITY	The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4 .
25732404	0	TLR4	92,96	Toll-like_Receptor_4	70,90	TLR4	Toll-like Receptor 4	7099	7099	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Epigallocatechin_Gallate -LRB- EGCG -RRB- Suppresses Lipopolysaccharide-Induced Toll-like_Receptor_4 -LRB- TLR4 -RRB- Activity via 67_kDa_Laminin_Receptor -LRB- 67LR -RRB- in 3T3-L1 Adipocytes .
18544275	0	TLR4	42,46	Toll-like_receptor_4	20,40	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The significance of Toll-like_receptor_4 -LRB- TLR4 -RRB- expression in patients with chronic hepatitis_B .
19398177	0	TLR4	60,64	Toll-like_receptor_4	38,58	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Evaluation of the polymorphism in the Toll-like_receptor_4 -LRB- TLR4 -RRB- genes of tympanosclerosis patients .
21356084	0	TLR4	22,26	Toll-like_receptor_4	0,20	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Toll-like_receptor_4 -LRB- TLR4 -RRB- expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis .
21664961	0	TLR4	68,72	Toll-like_receptor_4	46,66	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Therapeutic targeting of innate immunity with Toll-like_receptor_4 -LRB- TLR4 -RRB- antagonists .
21752456	0	TLR4	49,53	Toll-like_receptor_4	27,47	TLR4	Toll-like receptor 4	403417(Tax:9615)	403417(Tax:9615)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of Toll-like_receptor_4 -LRB- TLR4 -RRB- in healthy and infected canine endometrium .
22005564	0	TLR4	56,60	Toll-like_receptor_4	34,54	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Platelet parameters and platelet Toll-like_receptor_4 -LRB- TLR4 -RRB- expression in patients with sepsis , and the effect of a joint treatment-plan integrating traditional Chinese and western medicine : a clinical study -RSB- .
23027874	0	TLR4	108,112	Toll-like_receptor_4	86,106	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Profibrotic effect of interleukin-18 in HK-2 cells is dependent on stimulation of the Toll-like_receptor_4 -LRB- TLR4 -RRB- promoter and increased TLR4 expression .
26830904	0	TLR4	37,41	Toll-like_receptor_4	15,35	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of Toll-like_receptor_4 -LRB- TLR4 -RRB- with chronic plaque_type_psoriasis and psoriatic_arthritis .
26831416	0	TLR4	155,159	Toll-like_receptor_4	133,153	TLR4	Toll-like receptor 4	7099	7099	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
20109504	0	TLR4	84,88	Toll_Like_Receptor_4	62,82	TLR4	Toll Like Receptor 4	100066890(Tax:9796)	100066890(Tax:9796)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Bovine_papillomavirus_type_1 E2 and E7 proteins down-regulate Toll_Like_Receptor_4 -LRB- TLR4 -RRB- expression in equine fibroblasts .
22582869	0	TLR4	31,35	Tollip	63,69	TLR4	Tollip	7099	54472	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression and localization of TLR4 and its negative regulator Tollip in the placenta of early-onset and late-onset preeclampsia .
23353651	0	TLR4	31,35	Tollip	84,90	TLR4	Tollip	7099	54472	Gene	Gene	signaling|compound|START_ENTITY signaling|acl|induced induced|nmod|expression expression|compound|END_ENTITY	Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression .
25109435	0	TLR4	111,115	Tollip	36,42	TLR4	Tollip	7099	54472	Gene	Gene	regulating|dobj|START_ENTITY negatively|acl|regulating induction|nmod|negatively induction|nsubj|END_ENTITY	Epigallocatechin-3-gallate-mediated Tollip induction through the 67-kDa_laminin_receptor negatively regulating TLR4 signaling in endothelial cells .
26582088	0	TLR4	0,4	Twist1	59,65	TLR4	Twist1	21898(Tax:10090)	22160(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice .
16982271	0	TLR4	0,4	VEGF	26,30	TLR4	VEGF	21898(Tax:10090)	22339(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	TLR4 mediates LPS-induced VEGF expression in odontoblasts .
23185615	0	TLR4	67,71	VEGF	58,62	TLR4	VEGF	21898(Tax:10090)	22339(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY END_ENTITY|nmod|activation	Peroxiredoxin_1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1a .
16319097	0	TLR4	19,23	VIP	0,3	TLR4	VIP	7099	7432	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts .
15833358	0	TLR4	109,113	alpha-melanocyte-stimulating_hormone	34,70	TLR4	alpha-melanocyte-stimulating hormone	7099	5443	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	The immunomodulating neuropeptide alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- suppresses LPS-stimulated TLR4 with IRAK-M in macrophages .
23850770	0	TLR4	74,78	claudin-5	123,132	TLR4	claudin-5	29260(Tax:10116)	65131(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Neuroprotective effect of bicyclol in rat ischemic_stroke : down-regulates TLR4 , TLR9 , TRAF6 , NF-kB , MMP-9 and up-regulates claudin-5 expression .
26585510	0	TLR4	49,53	fetuin-A	7,15	TLR4	fetuin-A	7099	197	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|END_ENTITY	Plasma fetuin-A does not correlate with monocyte TLR4 in humans .
24508784	0	TLR4	179,183	fractalkine	142,153	TLR4	fractalkine	7099	6376	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Subendothelial resistin enhances monocyte transmigration in a co-culture of human endothelial and smooth_muscle_cells by mechanisms involving fractalkine , MCP-1 and activation of TLR4 and Gi/o proteins signaling .
26992429	0	TLR4	30,34	gp120	6,11	TLR4	gp120	7099	3700	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	HIV-1 gp120 signaling through TLR4 modulates innate immune activation in human macrophages and the biology of hepatic stellate cells .
22461698	0	TLR4	57,61	heat_shock_protein-70	14,35	TLR4	heat shock protein-70	21898(Tax:10090)	15511(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Intracellular heat_shock_protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium .
21633411	0	TLR4	97,101	interleukin_6	6,19	TLR4	interleukin 6	21898(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Early interleukin_6 production by leukocytes during ischemic_acute_kidney_injury is regulated by TLR4 .
25015829	0	TLR4	52,56	p120-catenin	22,34	TLR4	p120-catenin	21898(Tax:10090)	12388(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Differential role for p120-catenin in regulation of TLR4 signaling in macrophages .
24821721	0	TLR4	184,188	p38	190,193	TLR4	p38	7099	1432	Gene	Gene	specificity_protein_1|appos|START_ENTITY specificity_protein_1|dep|pathway pathway|amod|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
18174680	0	TLR4	104,108	toll-like_receptor_4	82,102	TLR4	toll-like receptor 4	7099	7099	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	The c.1-260C > T promoter variant of CD14 but not the c. 896A > G -LRB- p.D299G -RRB- variant of toll-like_receptor_4 -LRB- TLR4 -RRB- genes is associated with inflammatory_bowel_disease .
18493843	0	TLR4	51,55	toll-like_receptor_4	29,49	TLR4	toll-like receptor 4	7099	7099	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery and development of toll-like_receptor_4 -LRB- TLR4 -RRB- antagonists : a new paradigm for treating sepsis_and_other_diseases .
22872782	0	TLR4	73,77	toll-like_receptor_4	51,71	TLR4	toll-like receptor 4	7099	7099	Gene	Gene	fusion|appos|START_ENTITY fusion|amod|END_ENTITY	Respiratory_syncytial_virus fusion protein-induced toll-like_receptor_4 -LRB- TLR4 -RRB- signaling is inhibited by the TLR4 antagonists Rhodobacter_sphaeroides lipopolysaccharide and eritoran -LRB- E5564 -RRB- and requires direct interaction with MD-2 .
24259392	0	TLR4	88,92	toll-like_receptor_4	66,86	TLR4	toll-like receptor 4	29260(Tax:10116)	29260(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Epigallocatechin_gallate improves insulin signaling by decreasing toll-like_receptor_4 -LRB- TLR4 -RRB- activity in adipose tissues of high-fat diet rats .
25241065	0	TLR4	86,90	toll-like_receptor_4	64,84	TLR4	toll-like receptor 4	29260(Tax:10116)	29260(Tax:10116)	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Activation of adult rat CNS endothelial cells by opioid-induced toll-like_receptor_4 -LRB- TLR4 -RRB- signaling induces proinflammatory , biochemical , morphological , and behavioral sequelae .
16339542	0	TLR5	27,31	CD25	122,126	TLR5	CD25	7100	3559	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
16339542	0	TLR5	27,31	CD4	118,121	TLR5	CD4	7100	920	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|cells cells|compound|END_ENTITY	Human CD4 + T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25 + T regulatory cells .
24466264	0	TLR5	34,38	MAP1S	0,5	TLR5	MAP1S	7100	55201	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	MAP1S controls breast_cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression .
23287987	0	TLR5	22,26	Toll-like_receptor_5	0,20	TLR5	Toll-like receptor 5	7100	7100	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Toll-like_receptor_5 -LRB- TLR5 -RRB- expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma_of_the_tongue .
22250084	0	TLR5	130,134	epidermal_growth_factor_receptor	50,82	TLR5	epidermal growth factor receptor	7100	1956	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Membrane-tethered MUC1 mucin is phosphorylated by epidermal_growth_factor_receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88 .
15266299	0	TLR6	27,31	Toll-like_receptor_6	0,20	TLR6	Toll-like receptor 6	10333	10333	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Toll-like_receptor_6 gene -LRB- TLR6 -RRB- : single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma .
18652679	0	TLR7	41,45	B_cell_activation	20,37	TLR7	B cell activation	51284	29760	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of human B_cell_activation by TLR7 and TLR9 agonists .
21039888	0	TLR7	0,4	BlyS	65,69	TLR7	BlyS	51284	10673	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TLR7 regulates dendritic cell-dependent B-cell responses through BlyS in immune thrombocytopenic_purpura .
23284054	0	TLR7	0,4	CD8a	70,74	TLR7	CD8a	170743(Tax:10090)	12525(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	TLR7 triggering with polyuridylic_acid promotes cross-presentation in CD8a + conventional dendritic cells by enhancing antigen preservation and MHC_class_I_antigen permanence on the dendritic cell surface .
23935491	0	TLR7	9,13	IFN-a	33,38	TLR7	IFN-a	51284	3438	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Blocking TLR7 - and TLR9-mediated IFN-a production by plasmacytoid dendritic cells does not diminish immune activation in early SIV_infection .
15723075	0	TLR7	113,117	IFN-alpha	38,47	TLR7	IFN-alpha	170743(Tax:10090)	111654(Tax:10090)	Gene	Gene	interfering|nmod|START_ENTITY Sequence-specific|advcl|interfering Sequence-specific|dobj|induction induction|nmod|END_ENTITY	Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7 .
16887967	0	TLR7	0,4	IFN-alpha	27,36	TLR7	IFN-alpha	51284	3439	Gene	Gene	ligands|nsubj|START_ENTITY ligands|xcomp|induce induce|dobj|production production|amod|END_ENTITY	TLR7 ligands induce higher IFN-alpha production in females .
17565046	0	TLR7	88,92	IFN-alpha	37,46	TLR7	IFN-alpha	51284	3439	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Negative regulation of TLR9-mediated IFN-alpha induction by a small-molecule , synthetic TLR7 ligand .
25239130	0	TLR7	33,37	Mucolipin_1	0,11	TLR9	Mucolipin 1	54106	57192	Gene	Gene	responses|nummod|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	Mucolipin_1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes .
25211222	0	TLR7	55,59	RANTES	69,75	TLR7	RANTES	51284	6352	Gene	Gene	production|nummod|START_ENTITY production|compound|END_ENTITY	The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production .
18490763	0	TLR7	100,104	TLR7	46,50	TLR7	TLR7	170743(Tax:10090)	170743(Tax:10090)	Gene	Gene	agonists|compound|START_ENTITY comparison|nmod|agonists Analysis|dep|comparison Analysis|nmod|response response|nmod|stimulation stimulation|nummod|END_ENTITY	Analysis of the neuroinflammatory response to TLR7 stimulation in the brain : comparison of multiple TLR7 and/or TLR8 agonists .
18490763	0	TLR7	46,50	TLR7	100,104	TLR7	TLR7	170743(Tax:10090)	170743(Tax:10090)	Gene	Gene	stimulation|nummod|START_ENTITY response|nmod|stimulation Analysis|nmod|response Analysis|dep|comparison comparison|nmod|agonists agonists|compound|END_ENTITY	Analysis of the neuroinflammatory response to TLR7 stimulation in the brain : comparison of multiple TLR7 and/or TLR8 agonists .
18439678	0	TLR7	56,60	TLR8	8,12	TLR7	TLR8	51284	51311	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand , imiquimod .
18490763	0	TLR7	100,104	TLR8	112,116	TLR7	TLR8	170743(Tax:10090)	170744(Tax:10090)	Gene	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	Analysis of the neuroinflammatory response to TLR7 stimulation in the brain : comparison of multiple TLR7 and/or TLR8 agonists .
18490763	0	TLR7	46,50	TLR8	112,116	TLR7	TLR8	170743(Tax:10090)	170744(Tax:10090)	Gene	Gene	stimulation|nummod|START_ENTITY response|nmod|stimulation Analysis|nmod|response Analysis|dep|comparison comparison|nmod|agonists agonists|compound|END_ENTITY	Analysis of the neuroinflammatory response to TLR7 stimulation in the brain : comparison of multiple TLR7 and/or TLR8 agonists .
21811614	0	TLR7	91,95	TLR8	101,105	TLR7	TLR8	170743(Tax:10090)	170744(Tax:10090)	Gene	Gene	mediate|nmod|START_ENTITY mediate|dep|not not|dep|END_ENTITY	Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7 , not TLR8 .
20089701	0	TLR7	15,19	TLR9	0,4	TLR7	TLR9	170743(Tax:10090)	81897(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	TLR9 regulates TLR7 - and MyD88-dependent autoantibody production and disease in a murine model of lupus .
25907537	0	TLR7	28,32	TRIM35	0,6	TLR7	TRIM35	51284	23087	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	TRIM35 negatively regulates TLR7 - and TLR9-mediated type I interferon production by targeting IRF7 .
19426145	0	TLR7	126,130	Toll-like_receptor_7	104,124	TLR7	Toll-like receptor 7	51284	51284	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Nuclear factor kappaB -LRB- NF-kappaB -RRB- activation primes cells to a pro-inflammatory polarized response to a Toll-like_receptor_7 -LRB- TLR7 -RRB- agonist .
20728343	0	TLR8	31,35	CD133	50,55	TLR8	CD133	51311	8842	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Toll-like receptor -LRB- TLR -RRB- 7 and TLR8 expression on CD133 + cells in colorectal_cancer points to a specific role for inflammation-induced TLRs in tumourigenesis and tumour progression .
21321205	0	TLR8	104,108	IFN-beta	154,162	TLR8	IFN-beta	51311	3456	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	Phagosomal signaling by Borrelia_burgdorferi in human monocytes involves Toll-like receptor -LRB- TLR -RRB- 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta .
26969150	0	TLR8	0,4	LILRA3	19,25	TLR8	LILRA3	51311	11026	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency_virus_infection and correlates to CD4 counts and virus loads .
26928328	0	TLR8	70,74	NLRP3	57,62	TLR8	NLRP3	51311	114548	Gene	Gene	Activity|compound|START_ENTITY END_ENTITY|nmod|Activity	Coordinated Activation of Toll-Like_Receptor8 -LRB- TLR8 -RRB- and NLRP3 by the TLR8 Agonist , VTX-2337 , Ignites Tumoricidal Natural Killer Cell Activity .
18439678	0	TLR8	8,12	TLR7	56,60	TLR8	TLR7	51311	51284	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand , imiquimod .
18490763	0	TLR8	112,116	TLR7	100,104	TLR8	TLR7	170744(Tax:10090)	170743(Tax:10090)	Gene	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	Analysis of the neuroinflammatory response to TLR7 stimulation in the brain : comparison of multiple TLR7 and/or TLR8 agonists .
18490763	0	TLR8	112,116	TLR7	46,50	TLR8	TLR7	170744(Tax:10090)	170743(Tax:10090)	Gene	Gene	agonists|compound|START_ENTITY comparison|nmod|agonists Analysis|dep|comparison Analysis|nmod|response response|nmod|stimulation stimulation|nummod|END_ENTITY	Analysis of the neuroinflammatory response to TLR7 stimulation in the brain : comparison of multiple TLR7 and/or TLR8 agonists .
21811614	0	TLR8	101,105	TLR7	91,95	TLR8	TLR7	170744(Tax:10090)	170743(Tax:10090)	Gene	Gene	not|dep|START_ENTITY mediate|dep|not mediate|nmod|END_ENTITY	Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7 , not TLR8 .
22196370	0	TLR8	35,39	TLR9	48,52	TLR8	TLR9	51311	54106	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nsubj|activation	Dual or triple activation of TLR7 , TLR8 , and/or TLR9 by single-stranded oligoribonucleotides .
23490285	0	TLR9	24,28	Foxp3	37,42	TLR9	Foxp3	54106	50943	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	DNA methylation impairs TLR9 induced Foxp3 expression by attenuating IRF-7 binding activity in fulminant type 1 diabetes .
15470074	0	TLR9	119,123	IFN-alpha	141,150	TLR9	IFN-alpha	81897(Tax:10090)	111654(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Expansion of bone marrow IFN-alpha-producing dendritic cells in New Zealand Black -LRB- NZB -RRB- mice : high level expression of TLR9 and secretion of IFN-alpha in NZB bone marrow .
16365150	0	TLR9	0,4	TLR2	49,53	TLR9	TLR2	81897(Tax:10090)	24088(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium_tuberculosis .
24023674	0	TLR9	92,96	TLR2	0,4	TLR9	TLR2	81897(Tax:10090)	24088(Tax:10090)	Gene	Gene	contributions|nmod|START_ENTITY recruitment|nmod|contributions regulates|dobj|recruitment regulates|nsubj|END_ENTITY	TLR2 regulates neutrophil recruitment and cytokine production with minor contributions from TLR9 during hypersensitivity pneumonitis .
17599410	0	TLR9	0,4	TLR4	21,25	TLR9	TLR4	81897(Tax:10090)	21898(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells .
24121213	0	TLR9	6,10	TLR4	133,137	TLR9	TLR4	54106	7099	Gene	Gene	tagSNPs|compound|START_ENTITY influence|nsubj|tagSNPs influence|xcomp|aGVHD aGVHD|nmod|polymorphisms polymorphisms|nmod|genes genes|compound|END_ENTITY	Donor TLR9 gene tagSNPs influence susceptibility to aGVHD and CMV reactivation in the allo-HSCT setting without polymorphisms in the TLR4 and NOD2 genes .
24971461	0	TLR9	60,64	TLR4	54,58	TLR9	TLR4	54106	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
20089701	0	TLR9	0,4	TLR7	15,19	TLR9	TLR7	81897(Tax:10090)	170743(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	TLR9 regulates TLR7 - and MyD88-dependent autoantibody production and disease in a murine model of lupus .
22196370	0	TLR9	48,52	TLR8	35,39	TLR9	TLR8	54106	51311	Gene	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Dual or triple activation of TLR7 , TLR8 , and/or TLR9 by single-stranded oligoribonucleotides .
12573264	0	TLR9	66,70	Toll-like_receptor_9	39,59	TLR9	Toll-like receptor 9	54106	54106	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single-nucleotide polymorphisms in the Toll-like_receptor_9 gene -LRB- TLR9 -RRB- : frequencies , pairwise linkage disequilibrium , and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies .
17706295	0	TLR9	38,42	Toll-like_receptor_9	16,36	TLR9	Toll-like receptor 9	494547(Tax:9940)	494547(Tax:9940)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism of Toll-like_receptor_9 -LRB- TLR9 -RRB- gene in sheep .
22594374	0	TLR9	22,26	Toll-like_receptor_9	0,20	TLR9	Toll-like receptor 9	54106	54106	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Toll-like_receptor_9 -LRB- TLR9 -RRB- polymorphism associated with symptomatic malaria : a cohort study .
25576141	0	TLR9	36,40	Toll-like_receptor_9	14,34	TLR9	Toll-like receptor 9	397007(Tax:9823)	397007(Tax:9823)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Toll-like_receptor_9 -LRB- TLR9 -RRB- in the lungs and lymphoid tissue of pigs .
20980631	0	TLR9	57,61	latent_membrane_protein_1	4,29	TLR9	latent membrane protein 1	54106	9260	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	EBV latent_membrane_protein_1 is a negative regulator of TLR9 .
19130296	0	TLR9	100,104	toll-like_receptor_9	78,98	TLR9	toll-like receptor 9	54106	54106	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of a single nucleotide polymorphism in the exon 2 region of toll-like_receptor_9 -LRB- TLR9 -RRB- gene with susceptibility to systemic_lupus_erythematosus among Chinese .
19886865	0	TLRR	0,4	PP1	29,32	TLRR	PP1	286187	5464	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TLRR -LRB- lrrc67 -RRB- interacts with PP1 and is associated with a cytoskeletal complex in the testis .
21738792	0	TLRR	33,37	PP1	0,3	TLRR	PP1	69312(Tax:10090)	19047(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	PP1 forms an active complex with TLRR -LRB- lrrc67 -RRB- , a putative PP1 regulatory subunit , during the early stages of spermiogenesis in mice .
21738792	0	TLRR	33,37	PP1	59,62	TLRR	PP1	69312(Tax:10090)	19047(Tax:10090)	Gene	Gene	START_ENTITY|appos|subunit subunit|compound|END_ENTITY	PP1 forms an active complex with TLRR -LRB- lrrc67 -RRB- , a putative PP1 regulatory subunit , during the early stages of spermiogenesis in mice .
15972671	0	TLRs_3_and_4	61,73	polymeric_Ig_receptor	18,39	TLRs 3 and 4	polymeric Ig receptor	7098;7099	5284	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of the polymeric_Ig_receptor by signaling through TLRs_3_and_4 : linking innate and adaptive immune responses .
7958914	0	TLS	53,56	CHOP	108,112	TLS	CHOP	2521	1649	Gene	Gene	domain|nmod|START_ENTITY required|nsubjpass|domain required|nmod|END_ENTITY	A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP .
11278855	0	TLS	35,38	translocated_in_liposarcoma	40,67	TLS	translocated in liposarcoma	2521	2521	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of the pro-oncoprotein TLS -LRB- translocated_in_liposarcoma -RRB- in nuclear factor-kappa B p65-mediated transcription as a coactivator .
22675500	0	TLX	56,59	BCL11A	16,22	TLX	BCL11A	4179	53335	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The oncoprotein BCL11A binds to orphan nuclear receptor TLX and potentiates its transrepressive function .
18391013	0	TLX	28,31	LSD1	65,69	TLX	LSD1	4179	23028	Gene	Gene	function|nmod|START_ENTITY requires|nsubj|function requires|dobj|END_ENTITY	Transrepressive function of TLX requires the histone demethylase LSD1 .
25356871	0	TLX	0,3	MMP-2	14,19	TLX	MMP-2	4179	4313	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TLX activates MMP-2 , promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival .
9628820	0	TLX	53,56	tailless	38,46	TLX	tailless	4179	43656(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human homologue of the Drosophila tailless gene -LRB- TLX -RRB- : characterization and mapping to a region of common deletion in human lymphoid_leukemia on chromosome 6q21 .
19821827	0	TLX3	24,28	HOX11L2	30,37	TLX3	HOX11L2	30012	30012	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Prognostic relevance of TLX3 -LRB- HOX11L2 -RRB- expression in childhood_T-cell_acute_lymphoblastic_leukaemia treated with Berlin-Frankfurt-M __ nster -LRB- BFM -RRB- protocols containing early and late re-intensification elements .
3162891	0	TL_PST	68,74	thermolabile_phenol_sulfotransferase	30,66	TL PST	thermolabile phenol sulfotransferase	445329	445329	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Inheritance of human platelet thermolabile_phenol_sulfotransferase -LRB- TL_PST -RRB- activity .
2541074	0	TLiSA1	24,30	TGF_beta	0,8	TLiSA1	TGF beta	10666	7040	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	TGF_beta down-regulates TLiSA1 expression and inhibits the differentiation of precursor lymphocytes into CTL and LAK cells .
1328724	0	TM	38,40	thrombomodulin	22,36	TM	thrombomodulin	7056	7056	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	-LSB- Evaluation of plasma thrombomodulin -LRB- TM -RRB- levels in patients with liver_disease -RSB- .
20116378	0	TM	35,37	thrombomodulin	19,33	TM	thrombomodulin	7056	7056	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	JNK-ATF-2 inhibits thrombomodulin -LRB- TM -RRB- expression by recruiting histone_deacetylase4 -LRB- HDAC4 -RRB- and forming a transcriptional repression complex in the TM promoter .
7680353	0	TM	57,59	thrombomodulin	41,55	TM	thrombomodulin	7056	7056	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Relationship of thyroid states and serum thrombomodulin -LRB- TM -RRB- levels in patients with Graves ' _ disease : TM , a possible new marker of the peripheral activity of thyroid hormones .
9022347	0	TM	31,33	thrombomodulin	16,30	TM	thrombomodulin	7056	7056	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Study of serum thrombomodulin -LRB- TM -RRB- levels in patients with hyper - _ or_hypo - _ thyroidism -RSB- .
21656834	0	TM4SF1	0,6	androgen_receptor	24,41	TM4SF1	androgen receptor	4071	367	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	TM4SF1 , a novel primary androgen_receptor target gene over-expressed in human prostate_cancer and involved in cell migration .
10375401	0	TM5	31,34	P-glycoprotein	46,60	TM5	P-glycoprotein	7170	5243	Gene	Gene	loop|nmod|START_ENTITY loop|nmod|END_ENTITY	The extracellular loop between TM5 and TM6 of P-glycoprotein is required for reactivity with monoclonal antibody UIC2 .
20138239	0	TM7SF2	14,20	SREBP-2	33,40	TM7SF2	SREBP-2	7108	6721	Gene	Gene	promoter|nummod|START_ENTITY promoter|nmod|END_ENTITY	Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element , a GC-box , and an inverted CCAAT-box .
25139117	0	TM9SF2	16,22	PGRP-LC	141,148	TM9SF2	PGRP-LC	35335(Tax:7227)	39063(Tax:7227)	Gene	Gene	START_ENTITY|dep|Localization Localization|nmod|END_ENTITY	The Nonaspanins TM9SF2 and TM9SF4 Regulate the Plasma Membrane Localization and Signalling Activity of the Peptidoglycan_Recognition_Protein PGRP-LC in Drosophila .
25114259	0	TMC1	85,89	protocadherin_15	17,33	TMC1	protocadherin 15	567237(Tax:7955)	368476(Tax:7955)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tip-link protein protocadherin_15 interacts with transmembrane channel-like proteins TMC1 and TMC2 .
23936739	0	TMEFF2	0,6	AKT	21,24	TMEFF2	AKT	23671	207	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	TMEFF2 modulates the AKT and ERK signaling pathways .
23742080	0	TMEM106B	0,8	TMEM106B	27,35	TMEM106B	TMEM106B	54664	54664	Gene	Gene	levels|nummod|START_ENTITY levels|compound|END_ENTITY	TMEM106B p.T185S regulates TMEM106B protein levels : implications for frontotemporal_dementia .
23742080	0	TMEM106B	27,35	TMEM106B	0,8	TMEM106B	TMEM106B	54664	54664	Gene	Gene	levels|compound|START_ENTITY levels|nummod|END_ENTITY	TMEM106B p.T185S regulates TMEM106B protein levels : implications for frontotemporal_dementia .
21178100	0	TMEM106B	0,8	progranulin	19,30	TMEM106B	progranulin	54664	2896	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers .
25549946	0	TMEM126A	0,8	CD137	12,17	TMEM126A	CD137	66271(Tax:10090)	21942(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	TMEM126A , a CD137 ligand binding protein , couples with the TLR4 signal transduction pathway in macrophages .
25231974	0	TMEM16A	67,74	third_intracellular_loop_determine_anoctamin_1	19,65	TMEM16A	third intracellular loop determine anoctamin 1	55107	55107	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Two helices in the third_intracellular_loop_determine_anoctamin_1 -LRB- TMEM16A -RRB- activation by calcium .
25630304	0	TMEM16F	57,64	ANO6	51,55	TMEM16F	ANO6	196527	196527	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Selective serotonin reuptake inhibitors facilitate ANO6 -LRB- TMEM16F -RRB- current activation and phosphatidylserine exposure .
26819645	0	TMEM207	14,21	TMEM207	61,68	TMEM207	TMEM207	131920	131920	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|Relation Relation|nmod|END_ENTITY	Expression of TMEM207 in Colorectal_Cancer : Relation between TMEM207 and Intelectin-1 .
26819645	0	TMEM207	61,68	TMEM207	14,21	TMEM207	TMEM207	131920	131920	Gene	Gene	Relation|nmod|START_ENTITY Expression|dep|Relation Expression|nmod|END_ENTITY	Expression of TMEM207 in Colorectal_Cancer : Relation between TMEM207 and Intelectin-1 .
20386877	0	TMEM27	38,44	transmembrane_protein_27	12,36	TMEM27	transmembrane protein 27	57393	57393	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of transmembrane_protein_27 -LRB- TMEM27 -RRB- in islet physiology and its potential use as a beta cell mass biomarker .
26590303	0	TMEPAI	18,24	TCF7L2	37,43	TMEPAI	TCF7L2	56937	6934	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the TMEPAI promoter by TCF7L2 : the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene .
24933703	0	TMEPAI	0,6	TGF-b	16,21	TMEPAI	TGF-b	56937	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	TMEPAI inhibits TGF-b signaling by promoting lysosome degradation of TGF-b receptor and contributes to lung_cancer development .
24933703	0	TMEPAI	0,6	TGF-b	69,74	TMEPAI	TGF-b	56937	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|TGF-b TGF-b|acl|signaling signaling|advcl|promoting promoting|dobj|degradation degradation|nmod|receptor receptor|amod|END_ENTITY	TMEPAI inhibits TGF-b signaling by promoting lysosome degradation of TGF-b receptor and contributes to lung_cancer development .
18405662	0	TMP21	0,5	Abeta	16,21	TMP21	Abeta	10972	351	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	TMP21 regulates Abeta production but does not affect caspase-3 , p53 , and neprilysin .
21288367	0	TMPRSS11A	60,69	ECRG4	30,35	TMPRSS11A	ECRG4	339967	84417	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A -LRB- ECRG1 -RRB- to inhibit cancer cell growth in esophageal_carcinoma .
16951139	0	TMPRSS2	0,7	ERG	8,11	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|parataxis|provide provide|nsubj|deletions deletions|compound|END_ENTITY	TMPRSS2 : ERG fusion-associated deletions provide insight into the heterogeneity of prostate_cancer .
17108102	0	TMPRSS2	0,7	ERG	8,11	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|parataxis|relevant relevant|nsubj|fusion fusion|compound|END_ENTITY	TMPRSS2 : ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate_cancer , but is bypassed in late-stage androgen_receptor-negative prostate_cancer .
17172822	0	TMPRSS2	14,21	ERG	22,25	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|dep|fusion fusion|compound|END_ENTITY	Expression of TMPRSS2 : ERG gene fusion in prostate_cancer cells is an important prognostic factor for cancer progression .
17237811	0	TMPRSS2	0,7	ERG	8,11	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|dep|fusion fusion|compound|END_ENTITY	TMPRSS2 : ERG gene fusion associated with lethal prostate_cancer in a watchful waiting cohort .
17259299	0	TMPRSS2	17,24	ERG	25,28	TMPRSS2	ERG	7113	2078	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|fusion fusion|compound|END_ENTITY	Frequency of the TMPRSS2 : ERG gene fusion is increased in moderate to poorly differentiated prostate_cancers .
17637754	0	TMPRSS2	29,36	ERG	40,43	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|nmod|sequences sequences|compound|END_ENTITY	Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate_cancer .
19494719	0	TMPRSS2	33,40	ERG	41,44	TMPRSS2	ERG	7113	2078	Gene	Gene	expression|nmod|START_ENTITY Persistence|nmod|expression Persistence|dep|gene gene|compound|END_ENTITY	Persistence of expression of the TMPRSS2 : ERG fusion gene after pre-surgery androgen ablation may be associated with early prostate_specific_antigen relapse of prostate_cancer : preliminary results .
20147525	0	TMPRSS2	116,123	ERG	124,127	TMPRSS2	ERG	7113	2078	Gene	Gene	inducing|dobj|START_ENTITY inhibits|advcl|inducing alpha|dep|inhibits alpha|dep|END_ENTITY	1 -LCB- alpha -RCB- ,25 - Dihydroxyvitamin_D3 inhibits growth of VCaP_prostate_cancer cells despite inducing the growth-promoting TMPRSS2 : ERG gene fusion .
21378318	0	TMPRSS2	29,36	ERG	37,40	TMPRSS2	ERG	7113	2078	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|parataxis|fusion-positive fusion-positive|nsubj|END_ENTITY	miR-221 Is down-regulated in TMPRSS2 : ERG fusion-positive prostate_cancer .
22076164	0	TMPRSS2	26,33	ERG	35,38	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|dep|marker marker|nsubj|END_ENTITY	The oncogenic gene fusion TMPRSS2 : ERG is not a diagnostic or prognostic marker for ovarian_cancer .
22736790	0	TMPRSS2	4,11	ERG	12,15	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|dep|rearrangement rearrangement|compound|END_ENTITY	The TMPRSS2 : ERG rearrangement , ERG expression , and prostate_cancer outcomes : a cohort study and meta-analysis .
22860005	0	TMPRSS2	0,7	ERG	16,19	TMPRSS2	ERG	50528(Tax:10090)	13876(Tax:10090)	Gene	Gene	driven|dep|START_ENTITY driven|dobj|expression expression|compound|END_ENTITY	TMPRSS2 - driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation .
23086769	0	TMPRSS2	21,28	ERG	29,32	TMPRSS2	ERG	7113	2078	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|END_ENTITY	Correlation of urine TMPRSS2 : ERG and PCA3 to ERG + and total_prostate_cancer burden .
23086769	0	TMPRSS2	21,28	ERG	45,48	TMPRSS2	ERG	7113	2078	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|ERG ERG|nmod|+ +|compound|END_ENTITY	Correlation of urine TMPRSS2 : ERG and PCA3 to ERG + and total_prostate_cancer burden .
23244085	0	TMPRSS2	15,22	ERG	47,50	TMPRSS2	ERG	7113	2078	Gene	Gene	members|compound|START_ENTITY Fusion|nmod|members Fusion|appos|END_ENTITY	Fusion between TMPRSS2 and ETS family members -LRB- ERG , ETV1 , ETV4 -RRB- in prostate_cancers from northern China .
24149465	0	TMPRSS2	49,56	ERG	57,60	TMPRSS2	ERG	7113	2078	Gene	Gene	targeting|dobj|START_ENTITY vaccine|acl|targeting Development|nmod|vaccine Development|dep|END_ENTITY	Development of a peptide-based vaccine targeting TMPRSS2 : ERG fusion-positive prostate_cancer .
24297949	0	TMPRSS2	0,7	ERG	8,11	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|parataxis|predicts predicts|nsubj|fusion fusion|compound|END_ENTITY	TMPRSS2 : ERG gene fusion predicts subsequent detection of prostate_cancer in patients with high-grade prostatic_intraepithelial_neoplasia .
25007891	0	TMPRSS2	12,19	ERG	20,23	TMPRSS2	ERG	7113	2078	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of TMPRSS2 : ERG in molecular stratification of PCa and its association with tumor aggressiveness : a study in Brazilian patients .
25263440	0	TMPRSS2	0,7	ERG	8,11	TMPRSS2	ERG	50528(Tax:10090)	13876(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|blocks blocks|nsubj|END_ENTITY	TMPRSS2 : ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate_cancer proliferation .
25852077	0	TMPRSS2	52,59	ERG	60,63	TMPRSS2	ERG	7113	2078	Gene	Gene	START_ENTITY|dep|Status Status|compound|END_ENTITY	Obesity and Prostate_Cancer Risk According to Tumor TMPRSS2 : ERG Gene Fusion Status .
26935606	0	TMPRSS2	27,34	ERG	35,38	TMPRSS2	ERG	7113	2078	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|gene gene|compound|END_ENTITY	Functional analysis of the TMPRSS2 : ERG fusion gene in cisplatin - induced cell death .
26941365	0	TMPRSS2	50,57	ERG	58,61	TMPRSS2	ERG	7113	2078	Gene	Gene	variants|nmod|START_ENTITY Association|nmod|variants Association|dep|END_ENTITY	Association of prostate_cancer risk variants with TMPRSS2 : ERG status : evidence for distinct molecular subtypes .
18172298	0	TMPRSS2	20,27	ETV5	28,32	TMPRSS2	ETV5	7113	2119	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|END_ENTITY	Characterization of TMPRSS2 : ETV5 and SLC45A3 : ETV5 gene fusions in prostate_cancer .
24926821	0	TMPRSS2	20,27	vitamin_D_receptor	59,77	TMPRSS2	vitamin D receptor	7113	7421	Gene	Gene	START_ENTITY|dep|synergizes synergizes|nmod|END_ENTITY	The prostate_cancer TMPRSS2 : ERG fusion synergizes with the vitamin_D_receptor -LRB- VDR -RRB- to induce CYP24A1 expression-limiting VDR signaling .
23708855	0	TMPRSS4	94,101	EP2_receptor	29,41	TMPRSS4	EP2 receptor	214523(Tax:10090)	19217(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of soluble EP2_receptor on ovarian_tumor growth in nude_mice and utility of TMPRSS4 as a combinatorial molecular target .
21622652	0	TMPRSS6	14,21	BMP6	25,29	TMPRSS6	BMP6	164656	654	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of TMPRSS6 by BMP6 and iron in human cells and mice .
23649491	0	TMPRSS6	19,26	Matriptase-2	0,12	TMPRSS6	Matriptase-2	164656	164656	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Matriptase-2 gene -LRB- TMPRSS6 -RRB- variants associate with breast_cancer survival , and reduced expression is related to triple-negative breast_cancer .
24376517	0	TMPRSS6	23,30	STAT5	46,51	TMPRSS6	STAT5	71753(Tax:10090)	20850(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Inflammation regulates TMPRSS6 expression via STAT5 .
19907145	0	TMPRSS6	22,29	matriptase-2	8,20	TMPRSS6	matriptase-2	164656	164656	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of matriptase-2 -LRB- TMPRSS6 -RRB- in iron metabolism .
24756697	0	TMPRSS9	13,20	Polyserase-1	0,12	TMPRSS9	Polyserase-1	360200	360200	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Polyserase-1 / TMPRSS9 induces pro-tumor effects in pancreatic_cancer cells by activation of pro-uPA .
24874140	0	TMPase	69,75	thiamine_monophosphatase	43,67	TMPase	thiamine monophosphatase	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Effects of neonatal capsaicin treatment on thiamine_monophosphatase -LRB- TMPase -RRB- activity in the substantia gelatinosa of the rat spinal cord .
24993472	0	TMS1	61,65	DNA_methyltransferase	26,47	TMS1	DNA methyltransferase	10955	1786	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Arsenic_trioxide inhibits DNA_methyltransferase and restores TMS1 gene expression in K562 cells .
12194977	0	TMT	77,80	transmembrane_tryptase	53,75	TMT	transmembrane tryptase	25823	25823	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biochemical and functional characterization of human transmembrane_tryptase -LRB- TMT -RRB- / tryptase gamma .
22045338	0	TMX	14,17	mitochondria-associated_membrane	45,77	TMX	mitochondria-associated membrane	81542	6445	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Palmitoylated TMX and calnexin target to the mitochondria-associated_membrane .
26939244	0	TN-ALPHA	58,66	TUMOR_NECROSIS_FACTOR-ALPHA	29,56	TN-ALPHA	TUMOR NECROSIS FACTOR-ALPHA	7124	7124	Gene	Gene	VALUE|appos|START_ENTITY VALUE|nmod|END_ENTITY	VALUE OF CEREBROSPINAL FLUID TUMOR_NECROSIS_FACTOR-ALPHA -LRB- TN-ALPHA -RRB- FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS .
23043956	0	TN-C	29,33	tenascin-C	17,27	TN-C	tenascin-C	3371	3371	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Postmortem serum tenascin-C -LRB- TN-C -RRB- concentrations in forensic autopsy cases : A pilot study .
26675253	0	TNAP	70,74	Tissue-Nonspecific_Alkaline_Phosphatase	29,68	TNAP	Tissue-Nonspecific Alkaline Phosphatase	11647(Tax:10090)	11647(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Transgenic Overexpression of Tissue-Nonspecific_Alkaline_Phosphatase -LRB- TNAP -RRB- in Vascular Endothelium Results in Generalized Arterial_Calcification .
10567438	0	TNAP	81,85	tissue-nonspecific_alkaline_phosphatase	40,79	TNAP	tissue-nonspecific alkaline phosphatase	25586(Tax:10116)	25586(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression and activity of tissue-nonspecific_alkaline_phosphatase -LRB- TNAP -RRB- in rat odontogenic cells in vivo .
23639813	0	TNF	49,52	A_disintegrin_and_metalloproteinase_17	0,38	TNF	A disintegrin and metalloproteinase 17	21926(Tax:10090)	11491(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	A_disintegrin_and_metalloproteinase_17 regulates TNF and TNFR1 levels in inflammation and liver_regeneration in mice .
8989923	0	TNF	23,26	Alpha-fetoprotein	0,17	TNF	Alpha-fetoprotein	7124	174	Gene	Gene	factor|compound|START_ENTITY END_ENTITY|nmod|factor	Alpha-fetoprotein as a TNF resistance factor for the human hepatocarcinoma cell line HepG2 .
9458834	0	TNF	23,26	Angiotensin_II	0,14	TNF	Angiotensin II	7124	183	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Angiotensin_II induces TNF production by the thick ascending limb : functional implications .
16850160	0	TNF	20,23	C/EBPbeta	0,9	TNF	C/EBPbeta	7124	1051	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	C/EBPbeta regulates TNF induced MnSOD expression and protection against apoptosis .
10996218	0	TNF	72,75	C5a_receptor	25,37	TNF	C5a receptor	21926(Tax:10090)	12273(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Intracerebral complement C5a_receptor -LRB- CD88 -RRB- expression is regulated by TNF and lymphotoxin-alpha following closed_head_injury in mice .
11418127	0	TNF	42,45	CSN3	0,4	TNF	CSN3	7124	1448	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CSN3 interacts with IKKgamma and inhibits TNF - but not IL-1-induced NF-kappaB activation .
9218249	0	TNF	15,18	DHEAS	0,5	TNF	DHEAS	7124	6822	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	DHEAS inhibits TNF production in monocytes , astrocytes and microglial cells .
11527006	0	TNF	80,83	Endothelial_monocyte_activating_polypeptide_II	0,46	TNF	Endothelial monocyte activating polypeptide II	7124	9255	Gene	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Endothelial_monocyte_activating_polypeptide_II -LRB- EMAP_II -RRB- enhances the effect of TNF on tumor-associated_vasculature .
21617117	0	TNF	58,61	ErbB4	33,38	TNF	ErbB4	7124	2066	Gene	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	TNF-a_converting_enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival .
20814569	0	TNF	0,3	Ezh2	49,53	TNF	Ezh2	7124	2146	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression : implications in duchenne_muscular_dystrophy .
22095280	0	TNF	112,115	FLICE-inhibitory_protein	63,87	TNF	FLICE-inhibitory protein	21926(Tax:10090)	12633(Tax:10090)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	In mouse embryonic fibroblasts , neither caspase-8 nor cellular FLICE-inhibitory_protein -LRB- FLIP -RRB- is necessary for TNF to activate NF-kB , but caspase-8 is required for TNF to cause cell death , and induction of FLIP by NF-kB is required to prevent it .
1387891	0	TNF	0,3	GM-CSF	24,30	TNF	GM-CSF	7124	1437	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages .
12415586	0	TNF	89,92	HLA-DRB1	80,88	TNF	HLA-DRB1	7124	3123	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Nodular_disease in rheumatoid_arthritis : association with cigarette smoking and HLA-DRB1 / TNF gene interaction .
15356147	0	TNF	140,143	Histone_deacetylase_3	0,21	TNF	Histone deacetylase 3	7124	8841	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Histone_deacetylase_3 , a class I histone deacetylase , suppresses MAPK11-mediated activating_transcription_factor-2 activation and represses TNF gene expression .
15728492	0	TNF	15,18	IFN-gamma	99,108	TNF	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|control control|nmod|expression expression|nmod|END_ENTITY	Involvement of TNF and NF-kappa_B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages .
16465284	8	TNF	1418,1421	IFN-gamma	1408,1417	TNF	IFN-gamma	7124	3458	Gene	Gene	treatment|compound|START_ENTITY treatment|compound|END_ENTITY	RT-PCR experiments and immunoprecipitation assays showed a late but marked increase in the expression of alpha1 , alpha2 , alpha3 , and beta1 chains after IFN-gamma + TNF treatment of LAN-5 cells , and only alpha1_and_beta1 chains upon RA induction .
21744329	0	TNF	80,83	IFN-gamma	85,94	TNF	IFN-gamma	7124	3458	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
7578980	0	TNF	52,55	IFN-gamma	0,9	TNF	IFN-gamma	7124	3458	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|priming priming|amod|END_ENTITY	IFN-gamma priming of monocytes enhances LPS-induced TNF production by augmenting both transcription and MRNA stability .
9521083	0	TNF	97,100	IFN-gamma	86,95	TNF	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	IL-12|dep|START_ENTITY IL-12|dep|END_ENTITY	Small_bowel_enteropathy : role of intraepithelial lymphocytes and of cytokines -LRB- IL-12 , IFN-gamma , TNF -RRB- in the induction of epithelial cell death and renewal .
15708473	0	TNF	191,194	IFNgamma	154,162	TNF	IFNgamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Major histocompatibility complex -LRB- MHC2 + -RRB- perivascular macrophages in the axotomized facial motor nucleus are regulated by receptors for interferon-gamma -LRB- IFNgamma -RRB- and tumor_necrosis_factor -LRB- TNF -RRB- .
17928893	0	TNF	45,48	IFNgamma	88,96	TNF	IFNgamma	7124	3458	Gene	Gene	modulation|nmod|START_ENTITY modulation|parataxis|regulates regulates|dobj|production production|compound|END_ENTITY	Insights into gene modulation by therapeutic TNF and IFNgamma antibodies : TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome .
17928893	0	TNF	74,77	IFNgamma	88,96	TNF	IFNgamma	7124	3458	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Insights into gene modulation by therapeutic TNF and IFNgamma antibodies : TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome .
12417450	0	TNF	64,67	IL-10	50,55	TNF	IL-10	7124	3586	Gene	Gene	IFNg|compound|START_ENTITY END_ENTITY|dep|IFNg	Oral terbutaline differentially affects cytokine -LRB- IL-10 , IL-12 , TNF , IFNg -RRB- release in multiple_sclerosis patients and controls .
18950592	0	TNF	69,72	IL-10	0,5	TNF	IL-10	7124	3586	Gene	Gene	requires|nmod|START_ENTITY requires|nsubj|release release|compound|END_ENTITY	IL-10 release requires stronger toll-like_receptor_4-triggering than TNF : a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp -LRB- 299 -RRB- Gly on IL-10 release .
18950592	0	TNF	69,72	IL-10	172,177	TNF	IL-10	7124	3586	Gene	Gene	requires|nmod|START_ENTITY requires|parataxis|TLR4 TLR4|dobj|Gly Gly|nmod|release release|compound|END_ENTITY	IL-10 release requires stronger toll-like_receptor_4-triggering than TNF : a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp -LRB- 299 -RRB- Gly on IL-10 release .
20805562	0	TNF	53,56	IL-10	0,5	TNF	IL-10	7124	3586	Gene	Gene	gene|compound|START_ENTITY elongation|nmod|gene inhibits|dobj|elongation inhibits|nsubj|END_ENTITY	IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages .
21805465	0	TNF	38,41	IL-10	0,5	TNF	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY limits|dobj|production limits|nsubj|END_ENTITY	IL-10 limits production of pathogenic TNF by M1 myeloid cells through induction of nuclear NF-kB p50 member in Trypanosoma congolense_infection-resistant C57BL/6 mice .
24706909	0	TNF	33,36	IL-10	66,71	TNF	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|compound|START_ENTITY macrophage|dobj|production macrophage|nmod|expression expression|amod|END_ENTITY	T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation .
26742960	0	TNF	149,152	IL-10	166,171	TNF	IL-10	7124	3586	Gene	Gene	orchestrated|nmod|START_ENTITY orchestrated|nmod|END_ENTITY	Liver and blood cytokine microenvironment in HCV patients is associated to liver_fibrosis score : a proinflammatory cytokine ensemble orchestrated by TNF and tuned by IL-10 .
7561246	0	TNF	99,102	IL-10	13,18	TNF	IL-10	7124	3586	Gene	Gene	relation|acl|START_ENTITY SIRS|nmod|relation patients|nmod|SIRS -LSB-|nmod|patients -LSB-|dobj|role role|nmod|END_ENTITY	-LSB- The role of IL-10 in patients with SIRS -LRB- systemic_inflammatory_response_syndrome -RRB- -- in relation to TNF activity -RSB- .
8932773	0	TNF	26,29	IL-10	19,24	TNF	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|compound|END_ENTITY	Trypanosoma_cruzi : IL-10 , TNF , IFN-gamma , and IL-12 regulate innate and acquired immunity to infection .
9200476	0	TNF	15,18	IL-13	0,5	TNF	IL-13	21926(Tax:10090)	16163(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-13 inhibits TNF production but potentiates that of IL-6 in vivo and ex vivo in mice .
12441141	0	TNF	36,39	IL-1alpha	16,25	TNF	IL-1alpha	24835(Tax:10116)	24493(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of IL-1alpha , IL-1 RI , TNF , TNF-RI and TNF-RII during physiological drift of rat molar teeth -- an immunohistochemical and in situ hybridization study .
20493505	0	TNF	46,49	IL-1b	51,56	TNF	IL-1b	493755(Tax:9685)	768274(Tax:9685)	Gene	Gene	START_ENTITY|appos|production production|amod|END_ENTITY	Pathogen associated molecular pattern-induced TNF , IL-1b , IL-6 and CXCL-8 production from feline whole blood culture .
20798517	0	TNF	0,3	IL-4	28,32	TNF	IL-4	21926(Tax:10090)	16189(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	TNF increases expression of IL-4 and PARs in mast cells .
21744329	0	TNF	80,83	IL-5	61,65	TNF	IL-5	7124	3567	Gene	Gene	IL-13|dep|START_ENTITY IL-13|compound|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
10049519	0	TNF	74,77	IL-6	86,90	TNF	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|chemoattractant chemoattractant|amod|END_ENTITY	Generation of inflammatory cytokines in zymosan-induced pleurisy in rats : TNF induces IL-6 and cytokine-induced neutrophil chemoattractant -LRB- CINC -RRB- in vivo .
10722865	0	TNF	102,105	IL-6	84,88	TNF	IL-6	7124	3569	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production makes|parataxis|inhibits makes|ccomp|respond respond|nmod|END_ENTITY	Soluble interleukin-6_receptor -LRB- sIL-6R -RRB- makes IL-6R negative T cell line respond to IL-6 ; it inhibits TNF production .
10930297	0	TNF	59,62	IL-6	12,16	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|nmod|production induces|dobj|END_ENTITY	Lps induces IL-6 in the brain and in serum largely through TNF production .
17070836	0	TNF	120,123	IL-6	84,88	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY role|nmod|receptor differences|dep|role differences|appos|expression expression|compound|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
17070836	0	TNF	79,82	IL-6	84,88	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	differences|appos|START_ENTITY differences|appos|expression expression|compound|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
1878339	0	TNF	0,3	IL-6	62,66	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|vitro vitro|nmod|synthesis synthesis|nmod|END_ENTITY	TNF inhibits malaria hepatic stages in vitro via synthesis of IL-6 .
2001421	0	TNF	23,26	IL-6	63,67	TNF	IL-6	7124	3569	Gene	Gene	Tumor_necrosis_factor|appos|START_ENTITY inhibits|nsubj|Tumor_necrosis_factor inhibits|dobj|interleukin interleukin|amod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- inhibits interleukin -LRB- IL -RRB- -1 and/or IL-6 stimulated synthesis of C-reactive_protein -LRB- CRP -RRB- and serum_amyloid_A -LRB- SAA -RRB- in primary cultures of human hepatocytes .
21744329	0	TNF	80,83	IL-6	67,71	TNF	IL-6	7124	3569	Gene	Gene	IL-13|dep|START_ENTITY IL-13|dep|END_ENTITY	Assessment of the levels of nitric_oxide -LRB- NO -RRB- and cytokines -LRB- IL-5 , IL-6 , IL-13 , TNF , IFN-gamma -RRB- in giardiosis .
8164194	0	TNF	9,12	IL-6	14,18	TNF	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	milk|nmod|START_ENTITY milk|nsubj|production production|amod|END_ENTITY	In vitro TNF , IL-6 and IL-2 production by rat milk cells following Trichinella_spiralis_infection .
8244453	0	TNF	52,55	IL-6	68,72	TNF	IL-6	7124	3569	Gene	Gene	production|nmod|START_ENTITY inhibition|nmod|production inhibition|dep|not not|nmod|END_ENTITY	Chloroquine-induced inhibition of the production of TNF , but not of IL-6 , is affected by disruption of iron metabolism .
8589268	0	TNF	120,123	IL-6	179,183	TNF	IL-6	7124	3569	Gene	Gene	up-regulation|nmod|START_ENTITY production|dep|up-regulation regulate|dobj|production regulate|nmod|down-regulation down-regulation|nmod|production production|compound|END_ENTITY	Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes : up-regulation of TNF , IFN-gamma and IL-2 , in contrast to down-regulation of IL-6 production .
8955207	0	TNF	0,3	IL-6	77,81	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	p55|compound|START_ENTITY plays|nsubj|p55 plays|dobj|role role|nmod|increases increases|nmod|END_ENTITY	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF .
8955207	0	TNF	144,147	IL-6	77,81	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	injection|nmod|START_ENTITY plays|nmod|injection plays|dobj|role role|nmod|increases increases|nmod|END_ENTITY	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF .
9195128	0	TNF	67,70	IL-6	24,28	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of IL-6 on systemic and central production of TNF : a study with IL-6-deficient mice .
9216689	0	TNF	19,22	IL-6	26,30	TNF	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effect of blocking TNF on IL-6 levels and metastasis in a B16-BL6 melanoma/mouse model .
9228922	0	TNF	87,90	IL-6	0,4	TNF	IL-6	103694380	24498(Tax:10116)	Gene	Gene	control|nmod|START_ENTITY release|parataxis|control release|compound|END_ENTITY	IL-6 release after intestinal_ischemia / reperfusion in rats is under partial control of TNF .
9728802	0	TNF	132,135	IL-6	4,8	TNF	IL-6	7124	3569	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|gene gene|compound|END_ENTITY	The IL-6 gene expression by leukemic cells from acute_lymphoblastic_leukemia common and T type and modulation of IL-6 production by TNF .
10843739	0	TNF	87,90	IL-8	14,18	TNF	IL-8	7124	3576	Gene	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|gene gene|compound|END_ENTITY	Expression of IL-8 gene in human monocytes and lymphocytes : differential regulation by TNF and IL-1 .
11500086	0	TNF	0,3	IL-8	21,25	TNF	IL-8	7124	3576	Gene	Gene	promote|nsubj|START_ENTITY promote|dobj|transactivation transactivation|compound|END_ENTITY	TNF and CD95 promote IL-8 gene transactivation via independent elements in colon_carcinoma cells .
12960727	0	TNF	23,26	IL-8	17,21	TNF	IL-8	7124	3576	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Cytokines -LRB- IL-6 , IL-8 , TNF -RRB- : early and reliable predictors of severe acute_pancreatitis .
25409741	0	TNF	48,51	IL10	42,46	TNF	IL10	7124	3586	Gene	Gene	IL6|dep|START_ENTITY IL6|dep|END_ENTITY	A study of genes encoding cytokines -LRB- IL6 , IL10 , TNF -RRB- , cytokine receptors -LRB- IL6R , IL6ST -RRB- , and glucocorticoid_receptor -LRB- NR3C1 -RRB- and susceptibility to bronchopulmonary_dysplasia .
21594375	0	TNF	26,29	Interferon-gamma	0,16	TNF	Interferon-gamma	7124	3458	Gene	Gene	sensitivity|compound|START_ENTITY enhances|dobj|sensitivity enhances|nsubj|END_ENTITY	Interferon-gamma enhances TNF sensitivity in A172 human glioblastoma cell line .
14552388	0	TNF	37,40	Leptin	0,6	TNF	Leptin	443540(Tax:9940)	443534(Tax:9940)	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY END_ENTITY|appos|tumor_necrosis_factor-alpha	Leptin , tumor_necrosis_factor-alpha -LRB- TNF -RRB- , and CD14 in ovine adipose tissue and changes in circulating TNF in lean and fat sheep .
7916655	0	TNF	40,43	Lymphotoxin_beta	0,16	TNF	Lymphotoxin beta	7124	4050	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Lymphotoxin_beta , a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface .
16850160	0	TNF	20,23	MnSOD	32,37	TNF	MnSOD	7124	6648	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	C/EBPbeta regulates TNF induced MnSOD expression and protection against apoptosis .
15943902	0	TNF	49,52	NFkappaB	87,95	TNF	NFkappaB	7124	4790	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Distinct differences between TNF receptor 1 - and TNF receptor 2-mediated activation of NFkappaB .
20120526	0	TNF	111,114	Neuro-D	116,123	TNF	Neuro-D	7124	4760	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Retinopathy and nephropathy in type 1 diabetic patients -- association with polymorphysms of vitamin_D-receptor , TNF , Neuro-D and IL-1 receptor 1 genes .
20814569	0	TNF	0,3	Notch-1	13,20	TNF	Notch-1	7124	4851	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression : implications in duchenne_muscular_dystrophy .
21670314	0	TNF	0,3	Nrf2	41,45	TNF	Nrf2	7124	4780	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	TNF mediates the sustained activation of Nrf2 in human monocytes .
17982267	0	TNF	0,3	P-glycoprotein	14,28	TNF	P-glycoprotein	7124	5243	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TNF activates P-glycoprotein in cerebral microvascular endothelial cells .
26644796	0	TNF	0,3	Pentraxin3	17,27	TNF	Pentraxin3	7124	5806	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	TNF up-regulates Pentraxin3 expression in human airway smooth muscle cells via JNK and ERK1/2 MAPK pathways .
15806111	0	TNF	32,35	Protein_kinase_C-alpha	0,22	TNF	Protein kinase C-alpha	24835(Tax:10116)	24680(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Protein_kinase_C-alpha mediates TNF release process in RBL-2H3 mast cells .
9450998	0	TNF	30,33	Raf-1	14,19	TNF	Raf-1	7124	5894	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling .
26287732	0	TNF	0,3	RelB	23,27	TNF	RelB	7124	5971	Gene	Gene	Induction|compound|START_ENTITY Induction|nmod|END_ENTITY	TNF Induction of NF-kB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression .
15792558	0	TNF	50,53	TLR2	28,32	TNF	TLR2	21926(Tax:10090)	24088(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|modulation modulation|nmod|END_ENTITY	-LSB- Differential modulation of TLR2 and TLR4-induced TNF production by murin haemorrhagic_shock -RSB- .
17762182	0	TNF	21,24	TNF	69,72	TNF	TNF	7124	7124	Gene	Gene	receptors|compound|START_ENTITY role|nmod|receptors role|nmod|END_ENTITY	Differential role of TNF receptors in cellular trafficking of intact TNF .
17762182	0	TNF	69,72	TNF	21,24	TNF	TNF	7124	7124	Gene	Gene	role|nmod|START_ENTITY role|nmod|receptors receptors|compound|END_ENTITY	Differential role of TNF receptors in cellular trafficking of intact TNF .
3216223	0	TNF	0,3	TNF	23,26	TNF	TNF	7124	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
3216223	0	TNF	23,26	TNF	0,3	TNF	TNF	7124	7124	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
9839161	0	TNF	14,17	TNF	39,42	TNF	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|receptors receptors|compound|END_ENTITY	Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung_injury in mice .
9839161	0	TNF	39,42	TNF	14,17	TNF	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY Expression|nmod|receptors Expression|nmod|END_ENTITY	Expression of TNF and the necessity of TNF receptors in bleomycin-induced lung_injury in mice .
10357816	0	TNF	144,147	TNF-R1	94,100	TNF	TNF-R1	7124	7132	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Induction of cell death by tumour_necrosis_factor -LRB- TNF -RRB- receptor 2 , CD40 and CD30 : a role for TNF-R1 activation by endogenous membrane-anchored TNF .
17493155	0	TNF	43,46	TNF-alpha	32,41	TNF	TNF-alpha	7124	7124	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Significant association between TNF-alpha -LRB- TNF -RRB- promoter allele -LRB- -1031 C , -863 C , and -857 C -RRB- and cerebral_malaria in Thailand .
1670638	0	TNF	52,55	TNF-beta	118,126	TNF	TNF-beta	7124	4049	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY structure|nmod|tumor_necrosis_factor locus|nsubj|structure locus|parataxis|correlates correlates|nsubj|polymorphism polymorphism|nmod|intron intron|nmod|gene gene|amod|END_ENTITY	Polymorphic structure of the tumor_necrosis_factor -LRB- TNF -RRB- locus : an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino_acid in position 26 and a reduced level of TNF-beta production .
17767060	0	TNF	65,68	TNF-beta	32,40	TNF	TNF-beta	7124	4049	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of gene polymorphism of TNF-beta on the concentration of TNF in serum of patient with endometriosis -RSB- .
2249779	0	TNF	34,37	TNF-beta	75,83	TNF	TNF-beta	100009088(Tax:9986)	100328931(Tax:9986)	Gene	Gene	analysis|nmod|START_ENTITY locus|nsubj|analysis locus|xcomp|containing containing|advcl|encoding encoding|dobj|END_ENTITY	Structural analysis of the rabbit TNF locus , containing the genes encoding TNF-beta -LRB- lymphotoxin -RRB- and TNF-alpha -LRB- tumor necrosis factor -RRB- .
17070836	0	TNF	120,123	TNFR1	134,139	TNF	TNFR1	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
17070836	0	TNF	79,82	TNFR1	134,139	TNF	TNFR1	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	differences|appos|START_ENTITY differences|dep|role role|nmod|receptor receptor|appos|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
18317365	0	TNF	135,138	TNFR1	46,51	TNF	TNFR1	7124	7132	Gene	Gene	action|appos|START_ENTITY inhibition|nmod|action antibody|nmod|inhibition tumor_necrosis_factor_receptor_1|dep|antibody tumor_necrosis_factor_receptor_1|appos|END_ENTITY	A humanized tumor_necrosis_factor_receptor_1 -LRB- TNFR1 -RRB- - specific antagonistic antibody for selective inhibition of tumor_necrosis_factor -LRB- TNF -RRB- action .
20045350	0	TNF	58,61	TNFR1	92,97	TNF	TNFR1	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	variants|compound|START_ENTITY expressing|dobj|variants expressing|nmod|selectivity selectivity|nmod|END_ENTITY	Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2 .
20206684	0	TNF	13,16	TNFR1	153,158	TNF	TNFR1	7124	7132	Gene	Gene	derivatives|compound|START_ENTITY reveal|nsubj|derivatives reveal|dobj|stoichiometry stoichiometry|nmod|formation formation|nmod|END_ENTITY	Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2 .
25995337	0	TNF	53,56	TNFR1	76,81	TNF	TNFR1	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nmod|END_ENTITY	Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 .
9464804	0	TNF	127,130	TNFR1	55,60	TNF	TNFR1	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY sensitivity|dep|action sensitivity|nmod|transgenic_mice transgenic_mice|acl|expressing expressing|dobj|protein protein|compound|END_ENTITY	High sensitivity of transgenic_mice expressing soluble TNFR1 fusion protein to mycobacterial_infections : synergistic action of TNF and IFN-gamma in the differentiation of protective granulomas .
10544244	0	TNF	11,14	TRAF1	0,5	TNF	TRAF1	7124	7185	Gene	Gene	regulator|compound|START_ENTITY regulator|nsubj|END_ENTITY	TRAF1 is a TNF inducible regulator of NF-kappaB activation .
15289505	0	TNF	23,26	Tumor_necrosis_factor	0,21	TNF	Tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious_and_inflammatory_diseases .
20966071	0	TNF	131,134	VCAM-1	108,114	TNF	VCAM-1	7124	7412	Gene	Gene	treatment|compound|START_ENTITY critical|nmod|treatment critical|nmod|expression expression|compound|END_ENTITY	Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent_protein_kinase is critical for VCAM-1 expression upon TNF treatment .
24516119	0	TNF	22,25	VCAM-1	39,45	TNF	VCAM-1	7124	7412	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2 .
23328798	0	TNF	46,49	VEGF	91,95	TNF	VEGF	7124	7422	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	Combined inhibition of tumor_necrosis_factor -LRB- TNF -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- for the treatment of macular_edema of various etiologies : a short-term pilot study .
24882010	0	TNF	15,18	XIAP	0,4	TNF	XIAP	7124	331	Gene	Gene	restricts|dobj|START_ENTITY restricts|nsubj|END_ENTITY	XIAP restricts TNF - and RIP3-dependent cell death and inflammasome activation .
26546680	0	TNF	33,36	ZFP36	57,62	TNF	ZFP36	7124	7538	Gene	Gene	control|nmod|START_ENTITY control|appos|END_ENTITY	Negative feed-forward control of TNF by tristetraprolin -LRB- ZFP36 -RRB- is limited by the mitogen-activated protein kinase phosphatase , DUSP1 : implications for regulation by glucocorticoids .
15356147	0	TNF	140,143	activating_transcription_factor-2	81,114	TNF	activating transcription factor-2	7124	1386	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Histone_deacetylase_3 , a class I histone deacetylase , suppresses MAPK11-mediated activating_transcription_factor-2 activation and represses TNF gene expression .
19232662	0	TNF	76,79	beta2-microglobulin	29,48	TNF	beta2-microglobulin	7124	567	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	Interaction of human TNF and beta2-microglobulin with Tanapox_virus-encoded TNF inhibitor , TPV-2L .
1899225	0	TNF	0,3	c-fos	12,17	TNF	c-fos	21926(Tax:10090)	14281(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TNF induces c-fos via a novel pathway requiring conversion of arachidonic_acid to a lipoxygenase metabolite .
22095280	0	TNF	165,168	caspase-8	139,148	TNF	caspase-8	21926(Tax:10090)	12370(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	In mouse embryonic fibroblasts , neither caspase-8 nor cellular FLICE-inhibitory_protein -LRB- FLIP -RRB- is necessary for TNF to activate NF-kB , but caspase-8 is required for TNF to cause cell death , and induction of FLIP by NF-kB is required to prevent it .
3489188	0	TNF	18,21	granulocyte-monocyte_colony-stimulating_factor	44,90	TNF	granulocyte-monocyte colony-stimulating factor	7124	1437	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Recombinant human TNF induces production of granulocyte-monocyte_colony-stimulating_factor .
1572101	0	TNF	156,159	interferon-gamma	10,26	TNF	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	cisplatin|appos|START_ENTITY tumouricidal|nmod|cisplatin priming|xcomp|tumouricidal END_ENTITY|acl|priming	Effect of interferon-gamma priming on the activation of murine peritoneal macrophages to tumouricidal state by cisplatin , IL-1 , and tumour_necrosis_factor -LRB- TNF -RRB- : production of IL-1_and_TNF .
2495751	0	TNF	0,3	interferon-gamma	24,40	TNF	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	TNF in combination with interferon-gamma is cytotoxic to normal , untransformed mouse and rat embryo fibroblast-like cells .
3117378	0	TNF	109,112	interferon-gamma	54,70	TNF	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	mRNA|nmod|START_ENTITY accumulation|nmod|mRNA enhances|dobj|accumulation enhances|nsubj|Regulation Regulation|nmod|expression expression|dep|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
3117378	0	TNF	37,40	interferon-gamma	54,70	TNF	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|dep|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
19393188	0	TNF	0,3	jagged-1	17,25	TNF	jagged-1	7124	182	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent .
15034048	0	TNF	0,3	lymphotoxin-beta	30,46	TNF	lymphotoxin-beta	7124	4050	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	TNF and phorbol_esters induce lymphotoxin-beta expression through distinct pathways involving Ets and NF-kappa B family members .
24516119	0	TNF	22,25	mTORC2	81,87	TNF	mTORC2	7124	74343(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY antagonizes|dobj|induction antagonizes|nmod|END_ENTITY	Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2 .
1382704	0	TNF	38,41	p55	53,56	TNF	p55	7124	7132	Gene	Gene	factor|appos|START_ENTITY Involvement|nmod|factor receptors|nsubj|Involvement receptors|dobj|END_ENTITY	Involvement of tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 in TNF responses of acute_myeloid_leukemia blasts in vitro .
1382704	0	TNF	68,71	p55	53,56	TNF	p55	7124	7132	Gene	Gene	responses|compound|START_ENTITY receptors|nmod|responses receptors|dobj|END_ENTITY	Involvement of tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 in TNF responses of acute_myeloid_leukemia blasts in vitro .
15625085	0	TNF	30,33	p55	4,7	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|receptor receptor|amod|END_ENTITY	The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis .
15625085	0	TNF	8,11	p55	4,7	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis .
17468886	0	TNF	21,24	p55	17,20	TNF	p55	103694380	25625(Tax:10116)	Gene	Gene	alpha-receptor|compound|START_ENTITY alpha-receptor|amod|END_ENTITY	Up-regulation of p55 TNF alpha-receptor in dorsal root ganglia neurons following lumbar facet_joint_injury in rats .
19582157	0	TNF	15,18	p55	11,14	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Absence of p55 TNF receptor reduces atherosclerosis , but has no major effect on angiotensin II induced aneurysms in LDL_receptor_deficient mice .
22156959	0	TNF	43,46	p55	39,42	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Selective inhibition of intra-alveolar p55 TNF receptor attenuates ventilator-induced lung_injury .
23526821	0	TNF	184,187	p55	188,191	TNF	p55	7124	7132	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like_graft-versus-host_disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor .
7492782	0	TNF	178,181	p55	201,204	TNF	p55	7124	7132	Gene	Gene	factor|dep|START_ENTITY factor|dobj|END_ENTITY	Administration of recombinant human granulocyte-macrophage_colony-stimulating_factor after chemotherapy regulates the expression and secretion of monocyte tumor necrosis factor -LRB- TNF -RRB- and TNF receptors p55 and p75 .
7535144	0	TNF	51,54	p55	39,42	TNF	p55	7124	7132	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	TNF-alpha , the great imitator : role of p55 and p75 TNF receptors in hematopoiesis .
7592709	0	TNF	114,117	p55	118,121	TNF	p55	7124	7132	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Tumor necrosis factor induces lipopolysaccharide tolerance in a human adenocarcinoma cell line mainly through the TNF p55 receptor .
8018924	0	TNF	143,146	p55	139,142	TNF	p55	7124	7132	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Evidence that tumor_necrosis_factor_alpha -LRB- TNF -RRB- - induced activation of neutrophil respiratory burst on biologic surfaces is mediated by the p55 TNF receptor .
8018924	0	TNF	43,46	p55	139,142	TNF	p55	7124	7132	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY Evidence|dep|tumor_necrosis_factor_alpha Evidence|parataxis|mediated mediated|nmod|receptor receptor|amod|END_ENTITY	Evidence that tumor_necrosis_factor_alpha -LRB- TNF -RRB- - induced activation of neutrophil respiratory burst on biologic surfaces is mediated by the p55 TNF receptor .
8145037	0	TNF	83,86	p55	79,82	TNF	p55	7124	7132	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	A human tumor_necrosis_factor -LRB- TNF -RRB- alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon .
8381414	0	TNF	75,78	p55	71,74	TNF	p55	7124	7132	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- up-regulates the expression of p75 but not p55 TNF receptors , and both receptors mediate , independently of each other , up-regulation of transforming_growth_factor_alpha and epidermal_growth_factor_receptor mRNA .
8823362	0	TNF	62,65	p55	35,38	TNF	p55	7124	7132	Gene	Gene	Evidence|appos|START_ENTITY Evidence|nmod|role role|nmod|factor factor|amod|END_ENTITY	Evidence for exclusive role of the p55 tumor necrosis factor -LRB- TNF -RRB- receptor in mediating the TNF-induced collagenase expression by human dermal fibroblasts .
8955207	0	TNF	144,147	p55	13,16	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	injection|nmod|START_ENTITY plays|nmod|injection plays|nsubj|END_ENTITY	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF .
9103455	0	TNF	49,52	p55	30,33	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|shedding shedding|nmod|murine murine|amod|END_ENTITY	Constitutive shedding of both p55 and p75 murine TNF receptors in vivo .
9348317	0	TNF	45,48	p55	66,69	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY mediated|nsubjpass|activity mediated|nmod|TNF_receptors TNF_receptors|amod|END_ENTITY	Antiviral activity of tumor_necrosis_factor -LRB- TNF -RRB- is mediated via p55 and p75 TNF_receptors .
9407552	0	TNF	14,17	p55	37,40	TNF	p55	103694380	25625(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY Expression|nmod|receptors Expression|dep|END_ENTITY	Expression of TNF and TNF receptors -LRB- p55 and p75 -RRB- in the rat brain after focal cerebral_ischemia .
9551933	0	TNF	0,3	p55	55,58	TNF	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY reveal|nsubj|mice reveal|dobj|roles roles|nmod|END_ENTITY	TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation .
8144934	0	TNF	0,3	p60	35,38	TNF	p60	7124	8878	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|internalization internalization|nmod|receptor receptor|amod|END_ENTITY	TNF induces internalization of the p60 receptor and shedding of the p80 receptor .
8805640	0	TNF	57,60	p60	86,89	TNF	p60	7124	3437	Gene	Gene	B|nmod|START_ENTITY activation|nmod|B muteins|nsubj|activation muteins|xcomp|specific specific|nmod|END_ENTITY	Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors .
9237663	0	TNF	94,97	p60	90,93	TNF	p60	7124	8878	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine-331 in the p60 TNF receptor and inactivates the receptor-associated kinase .
23526821	0	TNF	155,158	p75	159,162	TNF	p75	7124	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like_graft-versus-host_disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor .
7706751	0	TNF	100,103	p75	96,99	TNF	p75	7124	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor .
8381414	0	TNF	23,26	p75	59,62	TNF	p75	7124	7133	Gene	Gene	Tumor_necrosis_factor|appos|START_ENTITY up-regulates|nsubj|Tumor_necrosis_factor up-regulates|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- up-regulates the expression of p75 but not p55 TNF receptors , and both receptors mediate , independently of each other , up-regulation of transforming_growth_factor_alpha and epidermal_growth_factor_receptor mRNA .
8805640	0	TNF	98,101	p80	94,97	TNF	p80	7124	8161	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors .
9036990	0	TNF	15,18	p80	70,73	TNF	p80	7124	8161	Gene	Gene	cytotoxicity|compound|START_ENTITY cytotoxicity|nmod|END_ENTITY	Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80 : requirement of the TNF_receptor-associated_factor-2 binding site .
9531270	0	TNF	26,29	p80	22,25	TNF	p80	7124	8161	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis , nuclear_factor-kappa_B activation , and c-Jun kinase activation .
10430614	0	TNF	94,97	pyk2	28,32	TNF	pyk2	7124	2185	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF .
3216223	0	TNF	0,3	rTNF	81,85	TNF	rTNF	7124	24835(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|TNF TNF|nmod|combination combination|nmod|END_ENTITY	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
3216223	0	TNF	111,114	rTNF	81,85	TNF	rTNF	21926(Tax:10090)	24835(Tax:10116)	Gene	Gene	TNF|nmod|START_ENTITY TNF|nmod|combination combination|nmod|END_ENTITY	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
3216223	0	TNF	23,26	rTNF	81,85	TNF	rTNF	7124	24835(Tax:10116)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
11041560	0	TNF	35,38	tumor_necrosis_factor	12,33	TNF	tumor necrosis factor	103694380	103694380	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of tumor_necrosis_factor -LRB- TNF -RRB- in the febrile and metabolic responses of rats to intraperitoneal injection of a high dose of lipopolysaccharide .
11181695	0	TNF	111,114	tumor_necrosis_factor	72,93	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Uncoupling the proinflammatory from the immunosuppressive properties of tumor_necrosis_factor -LRB- TNF -RRB- at the p55 TNF receptor level : implications for pathogenesis and therapy of autoimmune_demyelination .
12890427	1	TNF	109,112	tumor_necrosis_factor	75,96	TNF	tumor necrosis factor	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Modulation of tumor_necrosis_factor and soluble TNF receptors .
1330568	0	TNF	110,113	tumor_necrosis_factor	87,108	TNF	tumor necrosis factor	7124	7124	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Involvement of an Asn/Val cleavage site in the production of a soluble form of a human tumor_necrosis_factor -LRB- TNF -RRB- receptor .
15381183	0	TNF	43,46	tumor_necrosis_factor	20,41	TNF	tumor necrosis factor	7124	7124	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of different tumor_necrosis_factor -LRB- TNF -RRB- reactive agents on reverse signaling of membrane integrated TNF in monocytes .
15759114	0	TNF	31,34	tumor_necrosis_factor	8,29	TNF	tumor necrosis factor	554167(Tax:7955)	554167(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel tumor_necrosis_factor -LRB- TNF -RRB- gene present in tandem with theTNF-alpha gene on the same chromosome in teleosts .
15902922	0	TNF	35,38	tumor_necrosis_factor	12,33	TNF	tumor necrosis factor	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relation of tumor_necrosis_factor -LRB- TNF -RRB- gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers .
16093436	0	TNF	131,134	tumor_necrosis_factor	82,103	TNF	tumor necrosis factor	7124	7124	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	The immunocytokine scFv23/TNF sensitizes HER-2 / neu-overexpressing SKBR-3 cells to tumor_necrosis_factor -LRB- TNF -RRB- via up-regulation of TNF receptor-1 .
16385350	0	TNF	55,58	tumor_necrosis_factor	32,53	TNF	tumor necrosis factor	7124	7124	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	-LSB- Differences in pharmacology of tumor_necrosis_factor -LRB- TNF -RRB- antagonists -RSB- .
20012512	0	TNF	43,46	tumor_necrosis_factor	20,41	TNF	tumor necrosis factor	7124	7124	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Delayed addition of tumor_necrosis_factor -LRB- TNF -RRB- antagonists inhibits the generation of CD11c + dendritic cells derived from CD34 + cells exposed to TNF-alpha .
20038584	0	TNF	65,68	tumor_necrosis_factor	9,30	TNF	tumor necrosis factor	7124	7124	Gene	Gene	processing|nmod|START_ENTITY induces|dobj|processing induces|nsubj|END_ENTITY	Membrane tumor_necrosis_factor -LRB- TNF -RRB- induces p100 processing via TNF receptor-2 -LRB- TNFR2 -RRB- .
20712570	0	TNF	40,43	tumor_necrosis_factor	17,38	TNF	tumor necrosis factor	7124	7124	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The dual role of tumor_necrosis_factor -LRB- TNF -RRB- in cancer biology .
2280608	0	TNF	45,48	tumor_necrosis_factor	22,43	TNF	tumor necrosis factor	7124	7124	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A regulatory role for tumor_necrosis_factor -LRB- TNF -RRB- in ML-1 human myeloblastic_leukemia cell maturation .
24453410	0	TNF	36,39	tumor_necrosis_factor	13,34	TNF	tumor necrosis factor	7124	7124	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor -LRB- TNF -RRB- release from subtypes of T cells by agonists of proteinase activated receptors .
25985765	0	TNF	94,97	tumor_necrosis_factor	71,92	TNF	tumor necrosis factor	7124	7124	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	New strategies to address the pharmacodynamics and pharmacokinetics of tumor_necrosis_factor -LRB- TNF -RRB- inhibitors : A systematic analysis .
2703526	0	TNF	33,36	tumor_necrosis_factor	10,31	TNF	tumor necrosis factor	103694380	103694380	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor -LRB- TNF -RRB- on lipid metabolism in the diabetic rat .
2840563	0	TNF	34,37	tumor_necrosis_factor	11,32	TNF	tumor necrosis factor	103694380	103694380	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor -LRB- TNF -RRB- on lipolytic activities of rat heart .
2884771	0	TNF	34,37	tumor_necrosis_factor	11,32	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor -LRB- TNF -RRB- on transplanted tumors induced by methylcholanthrene in mice .
3099988	0	TNF	45,48	tumor_necrosis_factor	22,43	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- Protective effect of tumor_necrosis_factor -LRB- TNF -RRB- obtained by genetic recombination against experimental bacterial_or_fungal_infection -RSB- .
3117378	0	TNF	37,40	tumor_necrosis_factor	14,35	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
3192948	0	TNF	148,151	tumor_necrosis_factor	125,146	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor_necrosis_factor -LRB- TNF -RRB- activity .
3710767	0	TNF	34,37	tumor_necrosis_factor	11,32	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of tumor_necrosis_factor -LRB- TNF -RRB- into mouse peritoneal fluids by OK-432 , a streptococcal preparation .
6481965	0	TNF	37,40	tumor_necrosis_factor	14,35	TNF	tumor necrosis factor	7124	7124	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	-LSB- Induction of tumor_necrosis_factor -LRB- TNF -RRB- by OK-432 -RSB- .
8088324	0	TNF	103,106	tumor_necrosis_factor	80,101	TNF	tumor necrosis factor	7124	7124	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Control of established experimental allergic_encephalomyelitis by inhibition of tumor_necrosis_factor -LRB- TNF -RRB- activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins .
8205115	2	TNF	122,125	tumor_necrosis_factor	99,120	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Increment of tumor_necrosis_factor -LRB- TNF -RRB- activity in mouse sera by carboxamide-methylated light chain .
8319779	0	TNF	97,100	tumor_necrosis_factor	21,42	TNF	tumor necrosis factor	7124	7124	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of surface tumor_necrosis_factor -LRB- TNF -RRB- expression and possible facilitation of surface TNF release from human monocytic cells by granulocyte-macrophage_colony-stimulating_factor or gamma interferon in combination with 1,25-dihydroxyvitamin _ D3 .
8357820	0	TNF	30,33	tumor_necrosis_factor	35,56	TNF	tumor necrosis factor	7124	7124	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	In vitro cytostatic effect of TNF -LRB- tumor_necrosis_factor -RRB- entrapped in immunoliposomes on cells normally insensitive to TNF .
8574755	0	TNF	58,61	tumor_necrosis_factor	35,56	TNF	tumor necrosis factor	100009088(Tax:9986)	100009088(Tax:9986)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Alterations in alveolar macrophage tumor_necrosis_factor -LRB- TNF -RRB- response following hemorrhagic_shock .
8912851	0	TNF	92,95	tumor_necrosis_factor	69,90	TNF	tumor necrosis factor	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor_necrosis_factor -LRB- TNF -RRB- gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells .
9101449	0	TNF	43,46	tumor_necrosis_factor	20,41	TNF	tumor necrosis factor	103694380	103694380	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	The significance of tumor_necrosis_factor -LRB- TNF -RRB- levels for rejection of joint allograft .
9199176	0	TNF	91,94	tumor_necrosis_factor	68,89	TNF	tumor necrosis factor	7124	7124	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Induced expression of trimerized intracellular domains of the human tumor_necrosis_factor -LRB- TNF -RRB- p55 receptor elicits TNF effects .
9876493	0	TNF	38,41	tumor_necrosis_factor	15,36	TNF	tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	-LSB- Production of tumor_necrosis_factor -LRB- TNF -RRB- by macrophages and T-lymphocytes of rodents as affected by acute gamma-irradiation -RSB- .
12161343	0	TNF	48,51	tumor_necrosis_factor-alpha	19,46	TNF	tumor necrosis factor-alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	The involvement of tumor_necrosis_factor-alpha -LRB- TNF -RRB- as an intraovarian regulator of oocyte apoptosis in the neonatal rat .
7843077	0	TNF	43,46	tumor_necrosis_factor-alpha	14,41	TNF	tumor necrosis factor-alpha	7124	7124	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of tumor_necrosis_factor-alpha -LRB- TNF -RRB- as an exposure or risk marker in three French coal mining regions .
10027781	0	TNF	53,56	tumor_necrosis_factor_alpha	24,51	TNF	tumor necrosis factor alpha	7124	7124	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Polymorphism within the tumor_necrosis_factor_alpha -LRB- TNF -RRB- promoter region in patients with ankylosing_spondylitis .
18362084	0	TNF	55,58	tumor_necrosis_factor_alpha	26,53	TNF	tumor necrosis factor alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interleukin-10 -LRB- IL10 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF -RRB- gene polymorphisms in Parkinson 's _ disease patients .
21254282	0	TNF	46,49	tumor_necrosis_factor_alpha	17,44	TNF	tumor necrosis factor alpha	7124	7124	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Cancer risk with tumor_necrosis_factor_alpha -LRB- TNF -RRB- inhibitors : meta-analysis of randomized controlled trials of adalimumab , etanercept , and infliximab using patient level data .
10369700	0	TNF	38,41	tumour_necrosis_factor	14,36	TNF	tumour necrosis factor	7124	7124	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of tumour_necrosis_factor -LRB- TNF -RRB- induced apoptosis by soluble TNF receptors in Helicobacter_pylori_infection .
10457886	0	TNF	60,63	tumour_necrosis_factor	36,58	TNF	tumour necrosis factor	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Analysis of the polymorphism of the tumour_necrosis_factor -LRB- TNF -RRB- gene and promoter and of circulating TNF-alpha levels in heart-transplant patients suffering or not suffering from severe rejection .
12966432	0	TNF	41,44	tumour_necrosis_factor	17,39	TNF	tumour necrosis factor	7124	7124	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms in tumour_necrosis_factor -LRB- TNF -RRB- are associated with risk of bladder_cancer and grade of tumour at presentation .
24528189	0	TNF	160,163	tumour_necrosis_factor	136,158	TNF	tumour necrosis factor	7124	7124	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Multi-functional flow cytometry analysis of CD4 + T cells as an immune biomarker for latent_tuberculosis status in patients treated with tumour_necrosis_factor -LRB- TNF -RRB- antagonists .
7569774	0	TNF	101,104	tumour_necrosis_factor	77,99	TNF	tumour necrosis factor	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Metalloproteases and serineproteases are involved in the cleavage of the two tumour_necrosis_factor -LRB- TNF -RRB- receptors to soluble forms in the myeloid cell lines U-937 and THP-1 .
8608636	0	TNF	66,69	tumour_necrosis_factor	42,64	TNF	tumour necrosis factor	7124	7124	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Distribution of four polymorphisms in the tumour_necrosis_factor -LRB- TNF -RRB- genes in patients with inflammatory_bowel_disease -LRB- IBD -RRB- .
9692151	0	TNF	45,48	tumour_necrosis_factor	10,32	TNF	tumour necrosis factor	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Levels of tumour_necrosis_factor and soluble TNF receptors during malaria_fever_episodes in the community .
20120526	0	TNF	111,114	vitamin_D-receptor	91,109	TNF	vitamin D-receptor	7124	7421	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Retinopathy and nephropathy in type 1 diabetic patients -- association with polymorphysms of vitamin_D-receptor , TNF , Neuro-D and IL-1 receptor 1 genes .
26159107	0	TNF-Alpha	10,19	Caveolin-1	23,33	TNF-Alpha	Caveolin-1	7124	857	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|Expression Expression|compound|END_ENTITY	Effect of TNF-Alpha on Caveolin-1 Expression and Insulin Signaling During Adipocyte Differentiation and in Mature Adipocytes .
25145773	0	TNF-Alpha	140,149	IL-2	10,14	TNF-Alpha	IL-2	7124	3558	Gene	Gene	Inhibitors|compound|START_ENTITY Treated|nmod|Inhibitors Controls|nmod|Treated Controls|nsubj|END_ENTITY	Exogenous IL-2 Controls the Balance in Th1 , Th17 , and Treg Cell Distribution in Patients with Progressive Rheumatoid_Arthritis Treated with TNF-Alpha Inhibitors .
26842246	0	TNF-Alpha	60,69	TACE	135,139	TNF-Alpha	TACE	21926(Tax:10090)	11491(Tax:10090)	Gene	Gene	START_ENTITY|dep|Inhibition Inhibition|nmod|END_ENTITY	Alcohol Decreases Organic Dust-Stimulated Airway Epithelial TNF-Alpha Through a Nitric_Oxide and Protein_Kinase-Mediated Inhibition of TACE .
19716548	0	TNF-R	143,148	TNF-alpha	49,58	TNF-R	TNF-alpha	7132	7124	Gene	Gene	TNF_receptor|appos|START_ENTITY role|nmod|TNF_receptor suggests|dobj|role suggests|nsubj|Activation Activation|nmod|pathway pathway|nmod|END_ENTITY	Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland -LRB- HSG -RRB- cells in vitro , suggests a role for the TNF_receptor -LRB- TNF-R -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in Sj gren 's syndrome-associated autoimmune_sialadenitis .
20534702	0	TNF-R1	92,98	FAN	0,3	TNF-R1	FAN	7132	8439	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	FAN -LRB- factor associated with neutral sphingomyelinase activation -RRB- , a moonlighting protein in TNF-R1 signaling .
20385620	0	TNF-R1	86,92	IkappaBalpha	66,78	TNF-R1	IkappaBalpha	7132	4792	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	RSK2 mediates NF - -LCB- kappa -RCB- B activity through the phosphorylation of IkappaBalpha in the TNF-R1 pathway .
10357816	0	TNF-R1	94,100	TNF	144,147	TNF-R1	TNF	7132	7124	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Induction of cell death by tumour_necrosis_factor -LRB- TNF -RRB- receptor 2 , CD40 and CD30 : a role for TNF-R1 activation by endogenous membrane-anchored TNF .
12135690	0	TNF-R1	7,13	leptin	56,62	TNF-R1	leptin	7132	3952	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Plasma TNF-R1 and insulin concentrations in relation to leptin levels among normal and overweight children .
15353169	0	TNF-R1	58,64	tumor_necrosis_factor-alpha	18,45	TNF-R1	tumor necrosis factor-alpha	7132	7124	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Ethanol increases tumor_necrosis_factor-alpha receptor-1 -LRB- TNF-R1 -RRB- levels in hepatic , intestinal , and cardiac cells .
9743209	0	TNF-R2	58,64	tumour_necrosis_factor_receptor_2	23,56	TNF-R2	tumour necrosis factor receptor 2	7133	7133	Gene	Gene	proliferation|appos|START_ENTITY proliferation|amod|END_ENTITY	Antioestrogens enhance tumour_necrosis_factor_receptor_2 -LRB- TNF-R2 -RRB- expression and TNF-R2-mediated proliferation in activated T cells .
25005154	0	TNF-RI	43,49	TNF-a	79,84	TNF-RI	TNF-a	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	The effects of protein_malnutrition on the TNF-RI and NF-kB expression via the TNF-a signaling pathway .
15603867	0	TNF-RII	60,67	tumor_necrosis_factor_receptor_II	25,58	TNF-RII	tumor necrosis factor receptor II	7133	7133	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Relationship between the tumor_necrosis_factor_receptor_II -LRB- TNF-RII -RRB- gene polymorphism and sTNF-RII plasma levels in healthy controls and in rheumatoid_arthritis .
21320567	0	TNF-a	83,88	A2b_adenosine_receptor	38,60	TNF-a	A2b adenosine receptor	21926(Tax:10090)	11541(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY Regulation|nmod|signaling Regulation|nmod|END_ENTITY	Regulation of MMP-9 expression by the A2b_adenosine_receptor and its dependency on TNF-a signaling .
26376051	0	TNF-a	95,100	BDNF	56,60	TNF-a	BDNF	7124	627	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Association of serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- with diagnosis of delirium in oncology inpatients .
25301360	0	TNF-a	115,120	BMP2	0,4	TNF-a	BMP2	7124	650	Gene	Gene	Differentiation|nmod|START_ENTITY Differentiation|compound|END_ENTITY	BMP2 Increases Adipogenic Differentiation in the Presence of Dexamethasone , which is Inhibited by the Treatment of TNF-a in Human Adipose Tissue-Derived Stromal Cells .
22547990	0	TNF-a	0,5	CD40	29,33	TNF-a	CD40	7124	958	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	TNF-a promotes IFN-y-induced CD40 expression and antigen process in Myb-transformed hematological cells .
21142450	0	TNF-a	34,39	CD8	59,62	TNF-a	CD8	7124	925	Gene	Gene	signaling|amod|START_ENTITY Interference|nmod|signaling inhibits|nsubj|Interference inhibits|dobj|lung_injury lung_injury|compound|END_ENTITY	Interference with intraepithelial TNF-a signaling inhibits CD8 -LRB- + -RRB- T-cell-mediated lung_injury in influenza_infection .
22230585	0	TNF-a	23,28	CD8	81,84	TNF-a	CD8	7124	925	Gene	Gene	production|nmod|START_ENTITY leads|nsubj|production leads|nmod|response response|compound|END_ENTITY	Impaired production of TNF-a by dendritic cells of older adults leads to a lower CD8 + T cell response against influenza .
23571180	0	TNF-a	30,35	CD8	39,42	TNF-a	CD8	7124	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Anti-leukemia T cells in AML : TNF-a CD8 T cells may escape detection and possibly reflect a stage of functional impairment .
24223177	0	TNF-a	30,35	CD8	68,71	TNF-a	CD8	21926(Tax:10090)	925	Gene	Gene	processing|nmod|START_ENTITY expressed|nsubj|processing expressed|ccomp|required required|nsubjpass|cells cells|compound|END_ENTITY	ADAM17-mediated processing of TNF-a expressed by antiviral effector CD8 + T cells is required for severe T-cell-mediated lung_injury .
27062372	0	TNF-a	0,5	CIDEC	20,25	TNF-a	CIDEC	7124	63924	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	TNF-a downregulates CIDEC via MEK/ERK pathway in human adipocytes .
23781123	0	TNF-a	181,186	COX-2	167,172	TNF-a	COX-2	21926(Tax:10090)	17709(Tax:10090)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Biphasic modulation of NOS expression , protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock : downstream regulation of COX-2 , IL-1b , TNF-a , IL-6 , and HMGB1 expression .
23886206	0	TNF-a	83,88	COX-2	96,101	TNF-a	COX-2	21926(Tax:10090)	17709(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
25605194	0	TNF-a	69,74	CRP	76,79	TNF-a	CRP	7124	1401	Gene	Gene	Levels|dep|START_ENTITY Levels|dep|END_ENTITY	Effect of Intraoperative Glucose Fluctuation and Postoperative IL-6 , TNF-a , CRP Levels on the Short-term Prognosis of Patients with Intracranial Supratentorial_Neoplasms .
26524038	0	TNF-a	42,47	CRP	49,52	TNF-a	CRP	7124	1401	Gene	Gene	IL-6|amod|START_ENTITY IL-6|dep|END_ENTITY	-LSB- Values of Detecting the Levels of b2-MG , TNF-a , CRP , IL-6 in the Patients with Multiple_Myeloma -RSB- .
25562426	0	TNF-a	50,55	Claudin_1	64,73	TNF-a	Claudin 1	7124	9076	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	PKC - iPLA2-PGE2-PPARy signaling cascade mediates TNF-a induced Claudin_1 expression in human lung_carcinoma cells .
22575505	0	TNF-a	35,40	Clusterin	0,9	TNF-a	Clusterin	7124	1191	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Clusterin induces the secretion of TNF-a and the chemotactic migration of macrophages .
24702436	0	TNF-a	41,46	E-selectin	68,78	TNF-a	E-selectin	7124	6401	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Sirtuin_1 stabilization by HuR represses TNF-a - and glucose-induced E-selectin release and endothelial cell adhesiveness in vitro : relevance to human metabolic_syndrome .
26305550	0	TNF-a	144,149	EMT	129,132	TNF-a	EMT	21926(Tax:10090)	16428(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Curcumin combined with FAPac vaccine elicits effective antitumor response by targeting indolamine-2 ,3 - dioxygenase and inhibiting EMT induced by TNF-a in melanoma .
23583303	0	TNF-a	118,123	ERK	86,89	TNF-a	ERK	7124	5594	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	The transcription factor NFAT1 induces apoptosis through cooperation with Ras/Raf/MEK / ERK pathway and upregulation of TNF-a expression .
21294163	0	TNF-a	16,21	FOXO3a	0,6	TNF-a	FOXO3a	21926(Tax:10090)	56484(Tax:10090)	Gene	Gene	proliferation|amod|START_ENTITY inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	FOXO3a inhibits TNF-a - and IL-1b-induced astrocyte proliferation : Implication for reactive astrogliosis .
22479266	0	TNF-a	37,42	Fas_Ligand	0,10	TNF-a	Fas Ligand	21926(Tax:10090)	14103(Tax:10090)	Gene	Gene	Has|nmod|START_ENTITY Has|nsubj|END_ENTITY	Fas_Ligand Has a Greater Impact than TNF-a on Apoptosis and Inflammation in Ischemic_Acute_Kidney_Injury .
23432784	0	TNF-a	0,5	Fgl2	18,22	TNF-a	Fgl2	24835(Tax:10116)	84586(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	TNF-a upregulates Fgl2 expression in rat myocardial_ischemia / reperfusion injury .
26700816	0	TNF-a	0,5	FoxO1	15,20	TNF-a	FoxO1	21926(Tax:10090)	56458(Tax:10090)	Gene	Gene	Inhibits|compound|START_ENTITY END_ENTITY|nsubj|Inhibits	TNF-a Inhibits FoxO1 by Up-regulating MiR-705 to Aggravate Oxidative Damage in Bone Marrow-Derived Mesenchymal Stem Cells during Osteoporosis .
21072492	0	TNF-a	64,69	GM3_synthase	73,85	TNF-a	GM3 synthase	7124	8869	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Suppression of vascular smooth muscle cell responses induced by TNF-a in GM3_synthase gene transfected cells .
22320863	0	TNF-a	26,31	HIF-1a	0,6	TNF-a	HIF-1a	7124	3091	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	HIF-1a acts downstream of TNF-a to inhibit vasodilator-stimulated_phosphoprotein expression and modulates the adhesion and proliferation of breast_cancer cells .
25051011	0	TNF-a	0,5	HIF-1a	27,33	TNF-a	HIF-1a	7124	3091	Gene	Gene	increase|amod|START_ENTITY increase|nmod|END_ENTITY	TNF-a mediated increase of HIF-1a inhibits VASP expression , which reduces alveolar-capillary barrier function during acute_lung_injury -LRB- ALI -RRB- .
26741705	0	TNF-a	42,47	HIF-1a	11,17	TNF-a	HIF-1a	24835(Tax:10116)	29560(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Inhibiting HIF-1a Decreases Expression of TNF-a and Caspase-3 in Specific Brain Regions Exposed Kainic_Acid-Induced Status_Epilepticus .
21336543	0	TNF-a	112,117	HMGB1	152,157	TNF-a	HMGB1	7124	3146	Gene	Gene	production|appos|START_ENTITY production|nmod|cells cells|appos|production production|nummod|END_ENTITY	Different inhibitory effects of kynurenic_acid and a novel kynurenic_acid analogue on tumour_necrosis_factor-a -LRB- TNF-a -RRB- production by mononuclear cells , HMGB1 production by monocytes and HNP1-3 secretion by neutrophils .
22154216	0	TNF-a	0,5	HMGB1	27,32	TNF-a	HMGB1	7124	3146	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	TNF-a induced secretion of HMGB1 from non-immune canine mammary epithelial cells -LRB- MTH53A -RRB- .
25660311	0	TNF-a	46,51	HMGB1	0,5	TNF-a	HMGB1	21926(Tax:10090)	15289(Tax:10090)	Gene	Gene	Binds|nmod|START_ENTITY Binds|nsubj|END_ENTITY	HMGB1 Binds to Lipoteichoic_Acid and Enhances TNF-a and IL-6 Production through HMGB1-Mediated Transfer of Lipoteichoic_Acid to CD14 and TLR2 .
21305449	0	TNF-a	65,70	ICAM-1	79,85	TNF-a	ICAM-1	7124	3383	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Catechol , a bioactive degradation product of salicortin , reduces TNF-a induced ICAM-1 expression in human endothelial cells .
21507295	0	TNF-a	12,17	ICAM-1	21,27	TNF-a	ICAM-1	7124	3383	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of TNF-a on ICAM-1 and LFA-1 expression in peripheral blood mononuclear cells of children with febrile_seizures -RSB- .
22190402	0	TNF-a	71,76	ICAM-1	99,105	TNF-a	ICAM-1	7124	3383	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Arylalkyl_ketones , benzophenones , desoxybenzoins and chalcones inhibit TNF-a induced expression of ICAM-1 : structure-activity analysis .
23042271	0	TNF-a	101,106	ICAM-1	56,62	TNF-a	ICAM-1	7124	3383	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Protein C activation peptide inhibits the expression of ICAM-1 , VCAM-1 , and interleukin-8 induced by TNF-a in human dermal microvascular endothelial cells .
23548604	0	TNF-a	112,117	ICAM-1	9,15	TNF-a	ICAM-1	7124	3383	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Increase ICAM-1 and LFA-1 expression by cerebrospinal fluid of subarachnoid_hemorrhage patients : involvement of TNF-a .
25026345	0	TNF-a	57,62	ICAM-1	121,127	TNF-a	ICAM-1	7124	3383	Gene	Gene	tumor_necrosis_factor-a|appos|START_ENTITY tumor_necrosis_factor-a|dep|expression expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
25675437	0	TNF-a	0,5	ICAM-1	66,72	TNF-a	ICAM-1	7124	3383	Gene	Gene	PKC|compound|START_ENTITY PKC|parataxis|JNK1/2/c-Jun-Dependent JNK1/2/c-Jun-Dependent|dobj|Adhesion Adhesion|nmod|Induction Induction|compound|END_ENTITY	TNF-a Mediates PKC / JNK1/2/c-Jun-Dependent Monocyte Adhesion via ICAM-1 Induction in Human Retinal Pigment Epithelial Cells .
26413796	0	TNF-a	54,59	ICAM-1	92,98	TNF-a	ICAM-1	7124	3383	Gene	Gene	expression|amod|START_ENTITY expression|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Ultraviolet light-emitting-diode irradiation inhibits TNF-a and IFN-y-induced expression of ICAM-1 and STAT1 phosphorylation in human keratinocytes .
25086184	0	TNF-a	17,22	IGFBP-3	0,7	TNF-a	IGFBP-3	7124	3486	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IGFBP-3 inhibits TNF-a production and TNFR-2 signaling to protect against Retinal Endothelial Cell Apoptosis .
21685693	0	TNF-a	46,51	IL-10	0,5	TNF-a	IL-10	7124	3586	Gene	Gene	expression|nmod|START_ENTITY attenuated|dobj|expression attenuated|nsubj|overexpression overexpression|compound|END_ENTITY	IL-10 overexpression attenuated expression of TNF-a and IL-1b activated by lipopolysaccharide in astrocytes .
22845061	0	TNF-a	40,45	IL-10	46,51	TNF-a	IL-10	7124	3586	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Die-off ratio correlates with increased TNF-a : IL-10 ratio and decreased IVF success rates correctable with humira .
23723980	0	TNF-a	24,29	IL-10	31,36	TNF-a	IL-10	7124	3586	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|dep|END_ENTITY	The association between TNF-a , IL-10 gene polymorphisms and primary Sj gren 's syndrome : a meta-analysis and systemic review .
23880295	0	TNF-a	7,12	IL-10	0,5	TNF-a	IL-10	7124	3586	Gene	Gene	IFN-y|appos|START_ENTITY IFN-y|compound|END_ENTITY	IL-10 , TNF-a _ IFN-y : potential early biomarkers for preeclampsia .
24492460	0	TNF-a	0,5	IL-10	23,28	TNF-a	IL-10	7124	3586	Gene	Gene	blockade|amod|START_ENTITY induces|nsubj|blockade induces|dobj|expression expression|compound|END_ENTITY	TNF-a blockade induces IL-10 expression in human CD4 + T cells .
24610932	0	TNF-a	74,79	IL-10	68,73	TNF-a	IL-10	7124	3586	Gene	Gene	ratio|amod|START_ENTITY associates|dep|ratio associates|nmod|END_ENTITY	Immunologic human renal allograft injury associates with an altered IL-10 / TNF-a expression ratio in regulatory B cells .
24974875	0	TNF-a	15,20	IL-10	30,35	TNF-a	IL-10	7124	3586	Gene	Gene	IL-6|amod|START_ENTITY IL-6|dep|END_ENTITY	Association of TNF-a , TGF-b1 , IL-10 , IL-6 , and IFN-y gene polymorphism with acute rejection and infection in lung transplant recipients .
25978374	0	TNF-a	78,83	IL-10	119,124	TNF-a	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Mechanism Mechanism|amod|END_ENTITY	Lactobacillus_fermentum ZYL0401 Attenuates Lipopolysaccharide-Induced Hepatic TNF-a Expression and Liver_Injury via an IL-10 - and PGE2-EP4-Dependent Mechanism .
27049572	0	TNF-a	11,16	IL-10	25,30	TNF-a	IL-10	7124	3586	Gene	Gene	IL-6|amod|START_ENTITY IL-6|dep|END_ENTITY	A study of TNF-a , TGF-b , IL-10 , IL-6 , and IFN-y gene polymorphisms in patients with depression .
23566659	0	TNF-a	26,31	IL-15	0,5	TNF-a	IL-15	7124	3600	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	IL-15 that a regulator of TNF-a in patients with diabetes_mellitus_type_2 .
21752147	0	TNF-a	64,69	IL-1b	57,62	TNF-a	IL-1b	7124	3553	Gene	Gene	IL-6|compound|START_ENTITY END_ENTITY|appos|IL-6	In vitro secretion profile of pro-inflammatory cytokines IL-1b , TNF-a , IL-6 , and of human beta-defensins _ -LRB- HBD -RRB- -1 , HBD-2 , and HBD-3 from human chorioamniotic membranes after selective stimulation with Gardnerella_vaginalis .
21913564	0	TNF-a	72,77	IL-1b	59,64	TNF-a	IL-1b	7124	3553	Gene	Gene	Studies|acl|START_ENTITY Studies|amod|IL-6 IL-6|amod|END_ENTITY	-LSB- Studies on the level of proinflammatory cytokines IIL-1a , IL-1b , IL-6 , TNF-a in pregnant women with acute pyelonephritis -RSB- .
21930349	0	TNF-a	73,78	IL-1b	60,65	TNF-a	IL-1b	7124	3553	Gene	Gene	expression|appos|START_ENTITY expression|amod|IL-6 IL-6|amod|END_ENTITY	Immunohistochemical expression of proinflammatory cytokines IL-1b , IL-6 , TNF-a and involvement of COX-2 , quantitatively confirmed by Western blot analysis , in Wernicke 's _ encephalopathy .
22157665	0	TNF-a	10,15	IL-1b	36,41	TNF-a	IL-1b	7124	3553	Gene	Gene	IL-6|compound|START_ENTITY END_ENTITY|compound|IL-6	Increased TNF-a , IL-6 and decreased IL-1b immunohistochemical expression by the stromal spindle-shaped cells in the central_giant_cell_granuloma_of_the_jaws .
22610149	0	TNF-a	111,116	IL-1b	118,123	TNF-a	IL-1b	7124	3553	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Recombinant human endostatin inhibits adjuvant_arthritis by down-regulating VEGF expression and suppression of TNF-a , IL-1b production .
23623770	0	TNF-a	9,14	IL-1b	99,104	TNF-a	IL-1b	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|induction induction|nmod|END_ENTITY	Blocking TNF-a enhances Pseudomonas_aeruginosa-induced mortality in burn mice through induction of IL-1b .
23781123	0	TNF-a	181,186	IL-1b	174,179	TNF-a	IL-1b	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Biphasic modulation of NOS expression , protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock : downstream regulation of COX-2 , IL-1b , TNF-a , IL-6 , and HMGB1 expression .
23886206	0	TNF-a	83,88	IL-1b	103,108	TNF-a	IL-1b	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24972324	0	TNF-a	35,40	IL-1b	57,62	TNF-a	IL-1b	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	Transcription|nmod|START_ENTITY increased|nsubjpass|Transcription increased|nmod|END_ENTITY	Transcription of the gene encoding TNF-a is increased by IL-1b in rat and human islets and b-cell lines .
25434084	0	TNF-a	23,28	IL-1b	30,35	TNF-a	IL-1b	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
25507682	0	TNF-a	23,28	IL-1b	30,35	TNF-a	IL-1b	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Nitric_oxide mediated TNF-a , IL-1b gene expression in liver induced by crush_injury of rat 's soft tissues -RSB- .
25732721	0	TNF-a	46,51	IL-1b	53,58	TNF-a	IL-1b	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Pre-activation of mesenchymal stem cells with TNF-a , IL-1b and nitric_oxide enhances its paracrine effects on radiation-induced intestinal_injury .
24938899	0	TNF-a	75,80	IL-2	88,92	TNF-a	IL-2	24835(Tax:10116)	116562(Tax:10116)	Gene	Gene	IFN-y|compound|START_ENTITY IFN-y|appos|END_ENTITY	Analysis of Influence of Baicalin Joint Resveratrol Retention Enema on the TNF-a , SIgA , IL-2 , IFN-y of Rats with Respiratory_Syncytial_Virus Infection .
22246057	0	TNF-a	16,21	IL-33	0,5	TNF-a	IL-33	7124	90865	Gene	Gene	effects|amod|START_ENTITY regulates|dobj|effects regulates|nsubj|END_ENTITY	IL-33 regulates TNF-a dependent effects in synovial fibroblasts .
24522896	0	TNF-a	22,27	IL-33	0,5	TNF-a	IL-33	7124	90865	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	IL-33 is regulated by TNF-a in normal and psoriatic skin .
20856228	0	TNF-a	23,28	IL-6	68,72	TNF-a	IL-6	7124	3569	Gene	Gene	signaling|compound|START_ENTITY Blockade|nmod|signaling suppresses|nsubj|Blockade suppresses|dobj|END_ENTITY	RETRACTED : Blockade of TNF-a signaling suppresses the AREG-mediated IL-6 and IL-8 cytokines secretion induced by anti-Ro/SSA autoantibodies .
21251905	0	TNF-a	63,68	IL-6	43,47	TNF-a	IL-6	7124	3569	Gene	Gene	START_ENTITY|nsubj|interactions interactions|nmod|cell cell|amod|END_ENTITY	Consistent interactions between tumor cell IL-6 and macrophage TNF-a enhance the growth of human prostate_cancer cells in the bone of nude mouse .
21913564	0	TNF-a	72,77	IL-6	66,70	TNF-a	IL-6	7124	3569	Gene	Gene	Studies|acl|START_ENTITY Studies|amod|END_ENTITY	-LSB- Studies on the level of proinflammatory cytokines IIL-1a , IL-1b , IL-6 , TNF-a in pregnant women with acute pyelonephritis -RSB- .
21930349	0	TNF-a	73,78	IL-6	67,71	TNF-a	IL-6	7124	3569	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Immunohistochemical expression of proinflammatory cytokines IL-1b , IL-6 , TNF-a and involvement of COX-2 , quantitatively confirmed by Western blot analysis , in Wernicke 's _ encephalopathy .
22158445	0	TNF-a	73,78	IL-6	8,12	TNF-a	IL-6	7124	3569	Gene	Gene	blockers|amod|START_ENTITY predicts|nmod|blockers predicts|nsubj|polymorphism polymorphism|compound|END_ENTITY	-174 G/C _ IL-6 gene promoter polymorphism predicts therapeutic response to TNF-a blockers .
22194466	0	TNF-a	56,61	IL-6	90,94	TNF-a	IL-6	7124	3569	Gene	Gene	effects|nmod|START_ENTITY escape|dobj|effects escape|nmod|signaling signaling|compound|END_ENTITY	Metastatic cells can escape the proapoptotic effects of TNF-a through increased autocrine IL-6 / STAT3 signaling .
22405769	0	TNF-a	93,98	IL-6	146,150	TNF-a	IL-6	7124	3569	Gene	Gene	expression|nmod|START_ENTITY elicit|dobj|expression elicit|nmod|action action|nmod|END_ENTITY	Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF-a on macrophages through the autocrine action of IL-6 .
22760836	0	TNF-a	65,70	IL-6	26,30	TNF-a	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	interleukin_6|appos|START_ENTITY interleukin_6|appos|END_ENTITY	A study of interleukin_6 -LRB- IL-6 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF-a -RRB- serum levels in rats subjected to fecal_peritonitis and treated with intraperitoneal ropivacaine .
23886206	0	TNF-a	83,88	IL-6	110,114	TNF-a	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
25066751	0	TNF-a	83,88	IL-6	90,94	TNF-a	IL-6	7124	3569	Gene	Gene	IL-10|compound|START_ENTITY IL-10|appos|END_ENTITY	Sequential determination of serum viral titers , virus-specific IgG antibodies , and TNF-a , IL-6 , IL-10 , and IFN-y levels in patients with Crimean-Congo_hemorrhagic_fever .
25844135	0	TNF-a	40,45	IL-6	47,51	TNF-a	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The time-course and RNA interference of TNF-a , IL-6 , and IL-1b expression on neuropathic_pain induced by L5 spinal nerve transection in rats .
26045939	0	TNF-a	53,58	IL-6	60,64	TNF-a	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Corrigendum : The time-course and RNA interference of TNF-a , IL-6 , and IL-1b expression on neuropathic_pain induced by L5 spinal nerve transection in rats -LRB- Korean J Anesthesiol 2015 April 68 -LRB- 2 -RRB- : 159-169 -RRB- .
20827577	0	TNF-a	0,5	IL-8	37,41	TNF-a	IL-8	7124	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	TNF-a induces vectorial secretion of IL-8 in Caco-2 cells .
24455739	0	TNF-a	61,66	IL-8	30,34	TNF-a	IL-8	7124	3576	Gene	Gene	challenge|amod|START_ENTITY reduce|nmod|challenge reduce|dobj|production production|compound|END_ENTITY	Lactobacilli reduce chemokine IL-8 production in response to TNF-a and Salmonella challenge of Caco-2 cells .
25785032	0	TNF-a	46,51	IL-8	53,57	TNF-a	IL-8	7124	3576	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Ghrelin inhibits AngII - induced expression of TNF-a , IL-8 , MCP-1 in human umbilical vein endothelial cells .
20944558	0	TNF-a	54,59	Interleukin-25	0,14	TNF-a	Interleukin-25	7124	64806	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Interleukin-25 production is differently regulated by TNF-a and TGF-b1 in the human gut .
23129128	0	TNF-a	48,53	Kallikrein-binding_protein	0,26	TNF-a	Kallikrein-binding protein	21926(Tax:10090)	16625(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Kallikrein-binding_protein inhibits LPS-induced TNF-a by upregulating SOCS3 expression .
26881177	0	TNF-a	16,21	L-Selectin	50,60	TNF-a	L-Selectin	7124	6402	Gene	Gene	Significance|nmod|START_ENTITY Significance|dep|END_ENTITY	Significance of TNF-a and the Adhesion Molecules : L-Selectin and VCAM-1 in Papillary_Thyroid_Carcinoma .
23085658	0	TNF-a	66,71	LDLR	98,102	TNF-a	LDLR	21926(Tax:10090)	16835(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	c-IAP1 binds and processes PCSK9 protein : linking the c-IAP1 in a TNF-a pathway to PCSK9-mediated LDLR degradation pathway .
26125466	0	TNF-a	0,5	LH_Receptor	29,40	TNF-a	LH Receptor	24835(Tax:10116)	25477(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TNF-a Suppressed FSH-Induced LH_Receptor Expression Through Transcriptional Regulation in Rat Granulosa Cells .
25047119	0	TNF-a	17,22	Leptin	0,6	TNF-a	Leptin	21926(Tax:10090)	16846(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Leptin increases TNF-a expression and production through phospholipase_D1 in Raw 264.7 cells .
12003644	0	TNF-a	18,23	MAdCAM-1	46,54	TNF-a	MAdCAM-1	7124	8174	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB .
22658637	0	TNF-a	0,5	MCP-1	62,67	TNF-a	MCP-1	7124	6347	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effects effects|nmod|END_ENTITY	TNF-a modulates statin effects on secretion and expression of MCP-1 , PAI-1 and adiponectin in 3T3-L1 differentiated adipocytes .
24826069	0	TNF-a	50,55	MCP-1	17,22	TNF-a	MCP-1	24835(Tax:10116)	24770(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Retinal neuronal MCP-1 induced by AGEs stimulates TNF-a expression in rat microglia via p38 , ERK , and NF-kB pathways .
25785032	0	TNF-a	46,51	MCP-1	59,64	TNF-a	MCP-1	7124	6347	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Ghrelin inhibits AngII - induced expression of TNF-a , IL-8 , MCP-1 in human umbilical vein endothelial cells .
22810435	0	TNF-a	90,95	MIP-1b	97,103	TNF-a	MIP-1b	7124	6351	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Acute myocardial_infarction and cardiogenic_shock : prognostic impact of cytokines : INF-y , TNF-a , MIP-1b , G-CSF , and MCP-1b .
21344498	0	TNF-a	20,25	MMP-2	48,53	TNF-a	MMP-2	7124	4313	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	Combined effects of TNF-a , IL-1b , and HIF-1a on MMP-2 production in ACL fibroblasts under mechanical stretch : an in vitro study .
21867693	0	TNF-a	67,72	MMP-3	39,44	TNF-a	MMP-3	7124	4314	Gene	Gene	induced|nmod|START_ENTITY expression|dep|induced expression|compound|END_ENTITY	Protein kinase D1 mediates synergistic MMP-3 expression induced by TNF-a and bradykinin in human colonic myofibroblasts .
25956994	0	TNF-a	0,5	MMP-3	17,22	TNF-a	MMP-3	21926(Tax:10090)	17392(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	TNF-a stimulates MMP-3 production via PGE2 signalling through the NF-kB and p38_MAPK pathway in a murine cementoblast cell line .
21320567	0	TNF-a	83,88	MMP-9	14,19	TNF-a	MMP-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY Regulation|nmod|signaling Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of MMP-9 expression by the A2b_adenosine_receptor and its dependency on TNF-a signaling .
22440312	0	TNF-a	146,151	MMP-9	161,166	TNF-a	MMP-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	115 kDa serine protease confers sustained protection to visceral_leishmaniasis caused by Leishmania_donovani via IFN-y induced down-regulation of TNF-a mediated MMP-9 activity .
22572236	0	TNF-a	15,20	MMP-9	58,63	TNF-a	MMP-9	280943(Tax:9913)	282871(Tax:9913)	Gene	Gene	Involvement|nmod|START_ENTITY pathway|nsubj|Involvement pathway|nmod|release release|amod|END_ENTITY	Involvement of TNF-a and MAPK pathway in the intramammary MMP-9 release via degranulation of cow neutrophils during acute mammary gland involution .
22820188	0	TNF-a	0,5	MMP-9	108,113	TNF-a	MMP-9	7124	4318	Gene	Gene	promotes|dep|START_ENTITY promotes|nsubj|epithelial epithelial|dep|migration migration|acl|inducing inducing|dobj|expression expression|appos|END_ENTITY	TNF-a promotes human retinal pigment epithelial -LRB- RPE -RRB- cell migration by inducing matrix_metallopeptidase_9 -LRB- MMP-9 -RRB- expression through activation of Akt/mTORC1 signaling .
24200302	0	TNF-a	10,15	MMP-9	45,50	TNF-a	MMP-9	7124	4318	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|nmod|END_ENTITY	Targeting TNF-a suppresses the production of MMP-9 in human salivary gland cells .
24667088	0	TNF-a	94,99	MMP-9	8,13	TNF-a	MMP-9	280943(Tax:9913)	282871(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of MMP-9 in the breakdown of barrier integrity of the corneal endothelium in response to TNF-a .
25889878	0	TNF-a	12,17	MMP-9	26,31	TNF-a	MMP-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
25889878	0	TNF-a	12,17	MMP-9	26,31	TNF-a	MMP-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
20448050	0	TNF-a	0,5	MUC1	28,32	TNF-a	MUC1	21926(Tax:10090)	17829(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	TNF-a is a key regulator of MUC1 , an anti-inflammatory molecule , during airway Pseudomonas_aeruginosa_infection .
22198506	0	TNF-a	67,72	Mitogen-activated_protein_kinase_phosphatase-1	0,46	TNF-a	Mitogen-activated protein kinase phosphatase-1	21926(Tax:10090)	19252(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase-1 inhibits myocardial TNF-a expression and improves cardiac function during endotoxemia .
26667305	0	TNF-a	23,28	NF-kB	46,51	TNF-a	NF-kB	24835(Tax:10116)	81736(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Ashwagandha attenuates TNF-a - and LPS-induced NF-kB activation and CCL2 and CCL5 gene expression in NRK-52E cells .
22915753	0	TNF-a	0,5	Netrin-1	60,68	TNF-a	Netrin-1	21926(Tax:10090)	18208(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	TNF-a mediates macrophage-induced bystander effects through Netrin-1 .
20972877	0	TNF-a	29,34	PAR2	10,14	TNF-a	PAR2	21926(Tax:10090)	14063(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Effect of PAR2 in regulating TNF-a and NAD -LRB- P -RRB- H oxidase in coronary arterioles in type 2 diabetic mice .
20689998	0	TNF-a	31,36	PINCH	9,14	TNF-a	PINCH	7124	3987	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Neuronal PINCH is regulated by TNF-a and is required for neurite extension .
23496259	0	TNF-a	0,5	Per2	55,59	TNF-a	Per2	7124	8864	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	TNF-a modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells .
26508734	0	TNF-a	18,23	Pim-1	32,37	TNF-a	Pim-1	7124	5292	Gene	Gene	Isoforms|compound|START_ENTITY Isoforms|compound|END_ENTITY	Smac Mimetic with TNF-a Targets Pim-1 Isoforms and Reactive Oxygen Species Production to Abrogate Transformation from Blebbishields .
24113711	0	TNF-a	65,70	RIP1	17,21	TNF-a	RIP1	21926(Tax:10090)	19766(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dobj|effects	Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-a .
23552949	0	TNF-a	16,21	SIRT6	0,5	TNF-a	SIRT6	7124	51548	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl_lysine .
21777804	0	TNF-a	21,26	STARs	12,17	TNF-a	STARs	7124	137735	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Sam68 guest STARs in TNF-a signaling .
22194466	0	TNF-a	56,61	STAT3	95,100	TNF-a	STAT3	7124	6774	Gene	Gene	effects|nmod|START_ENTITY escape|dobj|effects escape|nmod|signaling signaling|compound|END_ENTITY	Metastatic cells can escape the proapoptotic effects of TNF-a through increased autocrine IL-6 / STAT3 signaling .
25491150	0	TNF-a	0,5	Syndecan-4	26,36	TNF-a	Syndecan-4	24835(Tax:10116)	24771(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNF-a and TGF-b1 regulate Syndecan-4 expression in nucleus pulposus cells : role of the mitogen-activated protein kinase and NF-kB pathways .
20652825	0	TNF-a	0,5	TGF-b	38,43	TNF-a	TGF-b	21926(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|amod|END_ENTITY	TNF-a mRNA expression correlates with TGF-b mRNA expression in vivo .
21893029	0	TNF-a	0,5	TGF-b	68,73	TNF-a	TGF-b	24835(Tax:10116)	59086(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	TNF-a increases cardiac fibroblast lysyl_oxidase expression through TGF-b and PI3Kinase signaling pathways .
23110133	0	TNF-a	95,100	TGF-b	121,126	TNF-a	TGF-b	24835(Tax:10116)	59086(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-a in combination with TGF-b in rats .
23319875	0	TNF-a	79,84	TGF-b	8,13	TNF-a	TGF-b	7124	7040	Gene	Gene	Production|compound|START_ENTITY Suppression|nmod|Production Role|dep|Suppression Role|nmod|END_ENTITY	Role of TGF-b in Survival of Phagocytizing Microglia : Autocrine Suppression of TNF-a Production and Oxidative Stress .
23638863	0	TNF-a	55,60	TGF-b	62,67	TNF-a	TGF-b	7124	7040	Gene	Gene	IL6|dep|START_ENTITY IL6|dep|END_ENTITY	Association of cytokine gene polymorphisms -LRB- IL6 , IL10 , TNF-a , TGF-b and IFN-y -RRB- and Graves ' _ disease in Turkish population .
25009639	0	TNF-a	0,5	TGF-b	29,34	TNF-a	TGF-b	7124	7040	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	TNF-a enhances the effect of TGF-b on Gli2 expression in the KG-1 leukemic cell line .
26729808	0	TNF-a	14,19	TGF-b	136,141	TNF-a	TGF-b	7124	7040	Gene	Gene	Reverse|nsubj|START_ENTITY Reverse|nmod|Implications Implications|compound|END_ENTITY	Transmembrane TNF-a Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-b : Therapeutic Implications .
27049572	0	TNF-a	11,16	TGF-b	18,23	TNF-a	TGF-b	7124	7040	Gene	Gene	IL-6|amod|START_ENTITY IL-6|dep|END_ENTITY	A study of TNF-a , TGF-b , IL-10 , IL-6 , and IFN-y gene polymorphisms in patients with depression .
24974875	0	TNF-a	15,20	TGF-b1	22,28	TNF-a	TGF-b1	7124	7040	Gene	Gene	IL-6|amod|START_ENTITY IL-6|dep|END_ENTITY	Association of TNF-a , TGF-b1 , IL-10 , IL-6 , and IFN-y gene polymorphism with acute rejection and infection in lung transplant recipients .
21377791	0	TNF-a	40,45	THP-1	66,71	TNF-a	THP-1	7124	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Ubiquitous hazardous metal lead induces TNF-a in human phagocytic THP-1 cells : primary role of ERK_1 / 2 .
21643507	0	TNF-a	53,58	THP-1	62,67	TNF-a	THP-1	7124	2736	Gene	Gene	Assays|nmod|START_ENTITY Assays|nmod|Cells Cells|compound|END_ENTITY	Two High Throughput Screen Assays for Measurement of TNF-a in THP-1 Cells .
22241121	0	TNF-a	60,65	THP-1	69,74	TNF-a	THP-1	7124	2736	Gene	Gene	production|nmod|START_ENTITY prevents|dobj|production prevents|nmod|cells cells|compound|END_ENTITY	High-density lipoprotein prevents SAA-induced production of TNF-a in THP-1 monocytic cells and peripheral blood mononuclear cells .
22410422	0	TNF-a	78,83	THP-1	108,113	TNF-a	THP-1	7124	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Inhibitory effect of Astragalus_polysaccharides on lipopolysaccharide-induced TNF-a and IL-1b production in THP-1 cells .
23643167	0	TNF-a	64,69	THP-1	82,87	TNF-a	THP-1	7124	2736	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	-LSB- Effect of recombinant human growth_hormone on the secretion of TNF-a and IL-6 by THP-1 cells and its correlation with the NF-kB pathway -RSB- .
23769984	0	TNF-a	14,19	THP-1	48,53	TNF-a	THP-1	7124	2736	Gene	Gene	production|amod|START_ENTITY Inhibition|nmod|production Inhibition|nmod|cells cells|compound|END_ENTITY	Inhibition of TNF-a production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants .
26700004	0	TNF-a	66,71	THP-1	96,101	TNF-a	THP-1	7124	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Human amnion mesenchymal cells inhibit lipopolysaccharide-induced TNF-a and IL-1b production in THP-1 cells .
25005154	0	TNF-a	79,84	TNF-RI	43,49	TNF-a	TNF-RI	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	The effects of protein_malnutrition on the TNF-RI and NF-kB expression via the TNF-a signaling pathway .
24789001	0	TNF-a	125,130	TNF-a	77,82	TNF-a	TNF-a	7124	7124	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Tuberculosis risk in patients treated with non-anti-tumor_necrosis_factor-a -LRB- TNF-a -RRB- targeted biologics and recently licensed TNF-a inhibitors : data from clinical trials and national registries .
24789001	0	TNF-a	77,82	TNF-a	125,130	TNF-a	TNF-a	7124	7124	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Tuberculosis risk in patients treated with non-anti-tumor_necrosis_factor-a -LRB- TNF-a -RRB- targeted biologics and recently licensed TNF-a inhibitors : data from clinical trials and national registries .
25369272	0	TNF-a	14,19	TNF-a	21,26	TNF-a	TNF-a	7124	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Modulation of TNF-a , TNF-a receptors and IL-6 after treatment with AM3 in professional cyclists .
25369272	0	TNF-a	21,26	TNF-a	14,19	TNF-a	TNF-a	7124	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Modulation of TNF-a , TNF-a receptors and IL-6 after treatment with AM3 in professional cyclists .
25263964	0	TNF-a	21,26	TNFR1	28,33	TNF-a	TNFR1	7124	7132	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the TNF-a , TNFR1 gene and risk of rheumatoid_arthritis in Chinese Han population .
25416967	0	TNF-a	43,48	TNFR1	60,65	TNF-a	TNFR1	7124	7132	Gene	Gene	receptors|amod|START_ENTITY responses|nmod|receptors responses|appos|END_ENTITY	Differential pro-inflammatory responses of TNF-a receptors -LRB- TNFR1 and TNFR2 -RRB- on LOX-1 signalling .
23998902	0	TNF-a	48,53	TRAF2	24,29	TNF-a	TRAF2	7124	7186	Gene	Gene	resistance|amod|START_ENTITY contribute|nmod|resistance contribute|nsubj|END_ENTITY	The E3 ubiquitin ligase TRAF2 can contribute to TNF-a resistance in FLT3-ITD-positive AML cells .
25889878	0	TNF-a	12,17	TRAF2	74,79	TNF-a	TRAF2	21926(Tax:10090)	22030(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
25889878	0	TNF-a	12,17	TRAF2	74,79	TNF-a	TRAF2	21926(Tax:10090)	22030(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
22642593	0	TNF-a	34,39	TREM-1	0,6	TNF-a	TREM-1	7124	54210	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	TREM-1 is a positive regulator of TNF-a and IL-8 production in U937 foam cells .
21907587	0	TNF-a	41,46	Tumor_Necrosis_Factor-alpha	12,39	TNF-a	Tumor Necrosis Factor-alpha	7124	7124	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of Tumor_Necrosis_Factor-alpha -LRB- TNF-a -RRB- in the pathogenesis of systemic_lupus_erythematosus .
24139907	0	TNF-a	25,30	Tumor_necrosis_factor-a	0,23	TNF-a	Tumor necrosis factor-a	7124	7124	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Tumor_necrosis_factor-a -LRB- TNF-a -RRB- -863 C/A promoter polymorphism is associated with type 2 diabetes in Tunisian population .
21607023	0	TNF-a	29,34	Tumor_necrosis_factor-alpha	0,27	TNF-a	Tumor necrosis factor-alpha	7124	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- levels in aqueous_humor of primary_open_angle_glaucoma .
24840001	0	TNF-a	52,57	VCAM-1	68,74	TNF-a	VCAM-1	24835(Tax:10116)	25361(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Co-treating mesenchymal stem cells with IL __ -1 b and TNF-a increases VCAM-1 expression and improves post-ischemic myocardial function .
27026343	0	TNF-a	101,106	VIP	0,3	TNF-a	VIP	7124	7432	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-a and enhances RvD1 .
23799152	0	TNF-a	93,98	WW_domain_containing_E3_ubiquitin_protein_ligase_1	0,50	TNF-a	WW domain containing E3 ubiquitin protein ligase 1	7124	11059	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	WW_domain_containing_E3_ubiquitin_protein_ligase_1 -LRB- WWP1 -RRB- negatively regulates TLR4-mediated TNF-a and IL-6 production by proteasomal degradation of TNF_receptor_associated_factor_6 -LRB- TRAF6 -RRB- .
21973049	0	TNF-a	0,5	aquaporin_5	15,26	TNF-a	aquaporin 5	7124	362	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TNF-a inhibits aquaporin_5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation .
23085658	0	TNF-a	66,71	c-IAP1	54,60	TNF-a	c-IAP1	21926(Tax:10090)	11796(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	c-IAP1 binds and processes PCSK9 protein : linking the c-IAP1 in a TNF-a pathway to PCSK9-mediated LDLR degradation pathway .
25533502	0	TNF-a	96,101	c-Jun	71,76	TNF-a	c-Jun	7124	3725	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Butein suppresses ICAM-1 expression through the inhibition of IkBa and c-Jun phosphorylation in TNF-a - and PMA-treated HUVECs .
22166956	0	TNF-a	28,33	clusterin	15,24	TNF-a	clusterin	7124	1191	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Implication of clusterin in TNF-a response of rheumatoid_synovitis : lesson from in vitro knock-down of clusterin in human synovial fibroblast cells .
24069158	0	TNF-a	0,5	cytosolic_phospholipase_A2	14,40	TNF-a	cytosolic phospholipase A2	7124	5321	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	TNF-a induces cytosolic_phospholipase_A2 expression in human lung epithelial cells via JNK1/2 - _ and_p38 MAPK-dependent AP-1 activation .
21212994	0	TNF-a	0,5	early_growth_response_gene-1	14,42	TNF-a	early growth response gene-1	7124	1958	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	TNF-a induces early_growth_response_gene-1 expression via ERK1/2 activation in endothelial cells .
21346775	0	TNF-a	0,5	filaggrin	20,29	TNF-a	filaggrin	7124	2312	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	TNF-a downregulates filaggrin and loricrin through c-Jun N-terminal kinase : role for TNF-a antagonists to improve skin barrier .
24993166	0	TNF-a	0,5	g0s2	14,18	TNF-a	g0s2	7124	50486	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	TNF-a reduces g0s2 expression and stimulates lipolysis through PPAR-y inhibition in 3T3-L1 adipocytes .
23643167	0	TNF-a	64,69	growth_hormone	29,43	TNF-a	growth hormone	7124	2688	Gene	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Effect of recombinant human growth_hormone on the secretion of TNF-a and IL-6 by THP-1 cells and its correlation with the NF-kB pathway -RSB- .
26408615	0	TNF-a	1,6	high_mobility_group_protein_B1	30,60	TNF-a	high mobility group protein B1	7124	3146	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	-LSB- TNF-a induces the release of high_mobility_group_protein_B1 through p38 mitogen-activated protein kinase pathway in microglia -RSB- .
22342441	0	TNF-a	177,182	iNOS	210,214	TNF-a	iNOS	21926(Tax:10090)	18126(Tax:10090)	Gene	Gene	cytokines|appos|START_ENTITY cytokines|dep|END_ENTITY	Inhibitory effects of bioactive leads isolated from Pseudomonas_aeruginosa PS3 and Pseudomonas_fluorescens PS7 on MAP kinases and down regulation of pro inflammatory cytokines -LRB- TNF-a , IL-1b -RRB- and mediators -LRB- NO , iNOS and COX -RRB- .
23886206	0	TNF-a	83,88	iNOS	90,94	TNF-a	iNOS	21926(Tax:10090)	18126(Tax:10090)	Gene	Gene	IL-2|compound|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
25423092	0	TNF-a	72,77	iNOS	79,83	TNF-a	iNOS	21926(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Gentiolactone , a secoiridoid_dilactone from Gentiana triflora , inhibits TNF-a , iNOS and Cox-2 mRNA expression and blocks NF-kB promoter activity in murine macrophages .
26690069	0	TNF-a	70,75	iNOS	48,52	TNF-a	iNOS	21926(Tax:10090)	18126(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Correlation Correlation|nmod|synthase synthase|appos|END_ENTITY	Correlation of inducible nitric_oxide synthase -LRB- iNOS -RRB- inhibition with TNF-a , caspase-1 , FasL and TLR-3 in pathogenesis of rabies in mouse model .
22382194	0	TNF-a	15,20	insulin	26,33	TNF-a	insulin	7124	3630	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|resistance resistance|compound|END_ENTITY	Association of TNF-a with insulin resistance in type_2_diabetes_mellitus .
21893029	0	TNF-a	0,5	lysyl_oxidase	35,48	TNF-a	lysyl oxidase	24835(Tax:10116)	24914(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	TNF-a increases cardiac fibroblast lysyl_oxidase expression through TGF-b and PI3Kinase signaling pathways .
24885472	0	TNF-a	33,38	miR-130a	16,24	TNF-a	miR-130a	7124	406919	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	NF-kB-modulated miR-130a targets TNF-a in cervical_cancer cells .
21271217	0	TNF-a	0,5	miR-19a	27,34	TNF-a	miR-19a	7124	406979	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	TNF-a is a novel target of miR-19a .
23224948	0	TNF-a	125,130	mmp-9	115,120	TNF-a	mmp-9	7124	4318	Gene	Gene	induction|amod|START_ENTITY Identifying|nmod|induction Identifying|nmod|region region|nmod|matrix_metalloproteinase_9 matrix_metalloproteinase_9|dep|END_ENTITY	Identifying the regulative role of NF-kB binding sites within promoter region of human matrix_metalloproteinase_9 -LRB- mmp-9 -RRB- by TNF-a induction .
25026345	0	TNF-a	57,62	p53	130,133	TNF-a	p53	7124	7157	Gene	Gene	tumor_necrosis_factor-a|appos|START_ENTITY tumor_necrosis_factor-a|dep|expression expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
22371757	0	TNF-a	23,28	p75	19,22	TNF-a	p75	7124	7133	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Do soluble p55 and p75 TNF-a receptor concentrations play a role in women with primary_sterility ?
26072064	0	TNF-a	96,101	peroxisome_proliferator-activated_receptor-y	18,62	TNF-a	peroxisome proliferator-activated receptor-y	7124	5468	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Crosstalk between peroxisome_proliferator-activated_receptor-y and mineralcorticoid receptor in TNF-a activated renal tubular cell .
22735261	0	TNF-a	0,5	sclerostin	34,44	TNF-a	sclerostin	21926(Tax:10090)	74499(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|stimulation stimulation|nmod|expression expression|compound|END_ENTITY	TNF-a mediates the stimulation of sclerostin expression in an estrogen-deficient_condition .
24446199	0	TNF-a	0,5	sclerostin	18,28	TNF-a	sclerostin	21926(Tax:10090)	74499(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNF-a upregulates sclerostin expression in obese mice fed a high-fat diet .
23338678	0	TNF-a	30,35	serotonin_transporter	81,102	TNF-a	serotonin transporter	7124	6532	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	The pro-inflammatory cytokine TNF-a regulates the activity and expression of the serotonin_transporter -LRB- SERT -RRB- in astrocytes .
21949132	0	TNF-a	0,5	syndecan-4	136,146	TNF-a	syndecan-4	7124	6385	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|END_ENTITY	TNF-a and IL-1b promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc .
23576453	0	TNF-a	51,56	syndecan-4	24,34	TNF-a	syndecan-4	7124	6385	Gene	Gene	mechanisms|nmod|START_ENTITY mechanisms|nmod|upregulation upregulation|amod|END_ENTITY	Molecular mechanisms of syndecan-4 upregulation by TNF-a in the endothelium-like EAhy926 cells .
20674553	0	TNF-a	71,76	tumor_necrosis_factor-a	46,69	TNF-a	tumor necrosis factor-a	7124	7124	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cell growth and potentiation of tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced apoptosis by a phenanthroindolizidine_alkaloid antofine in human colon_cancer cells .
21731245	0	TNF-a	39,44	tumor_necrosis_factor-a	14,37	TNF-a	tumor necrosis factor-a	7124	7124	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Evaluation of tumor_necrosis_factor-a -LRB- TNF-a -RRB- levels in plasma and their correlation with periodontal status in obese and non-obese subjects .
24469604	0	TNF-a	65,70	tumor_necrosis_factor-a	40,63	TNF-a	tumor necrosis factor-a	7124	7124	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Comparative effectiveness of cycling of tumor_necrosis_factor-a -LRB- TNF-a -RRB- inhibitors versus switching to non-TNF biologics in rheumatoid_arthritis patients with inadequate response to TNF-a inhibitor using a Bayesian approach .
25859403	0	TNF-a	86,91	tumor_necrosis_factor-a	61,84	TNF-a	tumor necrosis factor-a	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Oral administration of melatonin modulates the expression of tumor_necrosis_factor-a -LRB- TNF-a -RRB- gene in irradiated rat cervical spinal cord .
8988238	0	TNF-a	32,37	tumor_necrosis_factor-a	7,30	TNF-a	tumor necrosis factor-a	7124	7124	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Plasma tumor_necrosis_factor-a -LRB- TNF-a -RRB- levels in Gaucher_disease .
21850623	0	TNF-a	49,54	tumor_necrosis_factor-alpha	20,47	TNF-a	tumor necrosis factor-alpha	7124	7124	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Plasma visfatin and tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- levels in metabolic_syndrome .
23032984	0	TNF-a	90,95	tumor_necrosis_factor-alpha	61,88	TNF-a	tumor necrosis factor-alpha	7124	7124	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	T-cell_non-Hodgkin 's _ lymphomas reported to the FDA AERS with tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- inhibitors : results of the REFURBISH study .
23056223	0	TNF-a	107,112	tumour_necrosis_factor	83,105	TNF-a	tumour necrosis factor	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Anti diabetic effect of CL 316,243 -LRB- a b3-adrenergic agonist -RRB- by down regulation of tumour_necrosis_factor -LRB- TNF-a -RRB- expression .
21078557	0	TNF-a_converting_enzyme	46,69	TACE	71,75	TNF-a converting enzyme	TACE	57027(Tax:10116)	57027(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure based optimization of chromen-based TNF-a_converting_enzyme -LRB- TACE -RRB- inhibitors on S1 ' pocket and their quantitative structure-activity relationship -LRB- QSAR -RRB- study .
20103810	0	TNF-alpha	0,9	ABCA1	20,25	TNF-alpha	ABCA1	7124	19	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	TNF-alpha decreases ABCA1 expression and attenuates HDL cholesterol efflux in the human intestinal cell line Caco-2 .
19189937	0	TNF-alpha	0,9	ACAT1	25,30	TNF-alpha	ACAT1	7124	38	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	TNF-alpha stimulates the ACAT1 expression in differentiating monocytes to promote the CE-laden cell formation .
16728240	0	TNF-alpha	30,39	ALP	14,17	TNF-alpha	ALP	7124	250	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of ALP activity by TNF-alpha on human_dental_pulp .
16115611	0	TNF-alpha	20,29	Adiponectin	0,11	TNF-alpha	Adiponectin	7124	9370	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli .
11705740	0	TNF-alpha	36,45	Akt	0,3	TNF-alpha	Akt	21926(Tax:10090)	11651(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Akt protects mouse hepatocytes from TNF-alpha - and Fas-mediated apoptosis through NK-kappa B activation .
18557926	0	TNF-alpha	0,9	Akt	21,24	TNF-alpha	Akt	7124	207	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	TNF-alpha stimulates Akt by a distinct aPKC-dependent pathway in premalignant keratinocytes .
17353005	0	TNF-alpha	86,95	Apoprotein_E	0,12	TNF-alpha	Apoprotein E	7124	348	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	Apoprotein_E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF-alpha and IL-6 in macrophages .
12907458	0	TNF-alpha	55,64	Bcl-3	16,21	TNF-alpha	Bcl-3	7124	602	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages .
17916651	0	TNF-alpha	32,41	Bsep	91,95	TNF-alpha	Bsep	24835(Tax:10116)	83569(Tax:10116)	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Obstructive cholestasis induces TNF-alpha - and IL-1 - mediated periportal downregulation of Bsep and zonal regulation of Ntcp , Oatp1a4 , and Oatp1b2 .
10930293	0	TNF-alpha	14,23	C/EBPbeta	70,79	TNF-alpha	C/EBPbeta	7124	1051	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of TNF-alpha expression in normal macrophages : the role of C/EBPbeta .
15556647	0	TNF-alpha	31,40	CB2	82,85	TNF-alpha	CB2	7124	1269	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways .
17376761	0	TNF-alpha	0,9	CCN2	40,44	TNF-alpha	CCN2	7124	1490	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TNF-alpha , but not IFN-gamma , regulates CCN2 -LRB- CTGF -RRB- , collagen type I , and proliferation in mesangial cells : possible roles in the progression of renal_fibrosis .
15831559	0	TNF-alpha	124,133	CCR1	31,35	TNF-alpha	CCR1	21926(Tax:10090)	12768(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY inflammation|nmod|release mediates|nmod|inflammation mediates|nsubj|-RSB- -RSB-|acl|acting acting|nmod|receptor receptor|compound|END_ENTITY	MIP-1alpha -LSB- CCL3 -RSB- acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4 .
19592420	0	TNF-alpha	79,88	CCR1	0,4	TNF-alpha	CCR1	21926(Tax:10090)	12768(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha , TGFbeta-1 and IL-6 .
15304089	0	TNF-alpha	111,120	CCR7	23,27	TNF-alpha	CCR7	7124	1236	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways : role of TNF-alpha and MAPK .
11350737	0	TNF-alpha	13,22	CD14	64,68	TNF-alpha	CD14	21926(Tax:10090)	12475(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|role role|nmod|END_ENTITY	Induction of TNF-alpha and MnSOD by endotoxin : role of membrane CD14 and Toll-like_receptor-4 .
7547698	0	TNF-alpha	0,9	CD23	48,52	TNF-alpha	CD23	7124	2208	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TNF-alpha regulates IL-4-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
9122614	0	TNF-alpha	0,9	CD23	67,71	TNF-alpha	CD23	7124	2208	Gene	Gene	-|compound|START_ENTITY -|dep|expression expression|compound|END_ENTITY	TNF-alpha regulates GM-CSF - , _ IL-3 - or M-CSF-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
18053016	0	TNF-alpha	106,115	CD25	42,46	TNF-alpha	CD25	7124	3559	Gene	Gene	modulation|amod|START_ENTITY subjected|nmod|modulation subjected|nsubjpass|insufficiency insufficiency|nmod|cells cells|compound|END_ENTITY	The functional insufficiency of human CD4 + CD25 high T-regulatory cells in allergic_asthma is subjected to TNF-alpha modulation .
18178849	0	TNF-alpha	0,9	CD25	68,72	TNF-alpha	CD25	21926(Tax:10090)	16184(Tax:10090)	Gene	Gene	antagonism|amod|START_ENTITY generates|nsubj|antagonism generates|dobj|population population|nmod|cells cells|compound|END_ENTITY	TNF-alpha antagonism generates a population of antigen-specific CD4 + CD25 + T cells that inhibit protective immunity in murine histoplasmosis .
17164398	0	TNF-alpha	32,41	CD38	0,4	TNF-alpha	CD38	7124	952	Gene	Gene	priming|nmod|START_ENTITY required|advcl|priming required|nsubjpass|END_ENTITY	CD38 is required for priming by TNF-alpha : a mechanism for extracellular coordination of cell fate .
17322278	0	TNF-alpha	0,9	CD38	18,22	TNF-alpha	CD38	7124	952	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNF-alpha induced CD38 expression in human airway smooth muscle cells : role of MAP kinases and transcription factors NF-kappaB and AP-1 .
11009092	0	TNF-alpha	73,82	CD4	37,40	TNF-alpha	CD4	7124	920	Gene	Gene	thymocytes|nmod|START_ENTITY +|dobj|thymocytes END_ENTITY|acl|+	Sex steroids induce apoptosis of CD8 + CD4 + double-positive thymocytes via TNF-alpha .
11123285	0	TNF-alpha	46,55	CD4	113,116	TNF-alpha	CD4	7124	920	Gene	Gene	signal|nmod|START_ENTITY induces|nsubj|signal induces|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
12296856	0	TNF-alpha	68,77	CD4	118,121	TNF-alpha	CD4	7124	920	Gene	Gene	effects|nmod|START_ENTITY have|dobj|effects have|nmod|cells cells|amod|co-stimulation co-stimulation|nmod|END_ENTITY	Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T cells .
15733870	0	TNF-alpha	11,20	CD4	71,74	TNF-alpha	CD4	7124	920	Gene	Gene	store|compound|START_ENTITY operated|nsubj|store operated|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Persistent TNF-alpha exposure impairs store operated calcium influx in CD4 + T lymphocytes .
16301684	0	TNF-alpha	76,85	CD4	34,37	TNF-alpha	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY function|dep|role function|nmod|clones clones|compound|END_ENTITY	Effector function of diabetogenic CD4 Th1 T cell clones : a central role for TNF-alpha .
18053016	0	TNF-alpha	106,115	CD4	38,41	TNF-alpha	CD4	7124	920	Gene	Gene	modulation|amod|START_ENTITY subjected|nmod|modulation subjected|nsubjpass|insufficiency insufficiency|nmod|cells cells|compound|END_ENTITY	The functional insufficiency of human CD4 + CD25 high T-regulatory cells in allergic_asthma is subjected to TNF-alpha modulation .
18178849	0	TNF-alpha	0,9	CD4	64,67	TNF-alpha	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	antagonism|amod|START_ENTITY generates|nsubj|antagonism generates|dobj|population population|nmod|cells cells|compound|END_ENTITY	TNF-alpha antagonism generates a population of antigen-specific CD4 + CD25 + T cells that inhibit protective immunity in murine histoplasmosis .
19667063	0	TNF-alpha	10,19	CD4	94,97	TNF-alpha	CD4	7124	920	Gene	Gene	synthesis|amod|START_ENTITY Decreased|dobj|synthesis Decreased|nsubj|cells cells|nummod|END_ENTITY	Decreased TNF-alpha synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4 + T cells during aging .
19931858	0	TNF-alpha	23,32	CD4	83,86	TNF-alpha	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	responsible|nsubj|START_ENTITY responsible|nmod|development development|nmod|cells cells|compound|END_ENTITY	Dendritic cell-derived TNF-alpha is responsible for development of IL-10-producing CD4 + T cells .
20173391	0	TNF-alpha	0,9	CD4	27,30	TNF-alpha	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|activator activator|nmod|cells cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20364089	0	TNF-alpha	73,82	CD4	100,103	TNF-alpha	CD4	7124	920	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Control_of_vaccinia_virus skin_lesions by long-term-maintained IFN-gamma + TNF-alpha + effector/memory CD4 + lymphocytes in humans .
2228021	0	TNF-alpha	23,32	CD4	49,52	TNF-alpha	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Evidence|nmod|role Evidence|nmod|cytolysis cytolysis|nmod|+ +|compound|END_ENTITY	Evidence of a role for TNF-alpha in cytolysis by CD4 + , class II MHC-restricted cytotoxic T cells .
7517419	0	TNF-alpha	0,9	CD4	125,128	TNF-alpha	CD4	24835(Tax:10116)	24932(Tax:10116)	Gene	Gene	associated|advmod|START_ENTITY associated|dep|enhances enhances|dobj|adhesion adhesion|nmod|T T|compound|END_ENTITY	TNF-alpha associated with fibronectin enhances phorbol_myristate_acetate - or antigen-mediated integrin-dependent adhesion of CD4 + T cells via protein tyrosine phosphorylation .
9218822	0	TNF-alpha	38,47	CD4	90,93	TNF-alpha	CD4	7124	920	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|nmod|induction induction|nmod|anergy anergy|compound|END_ENTITY	Role of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- in the induction of HIV-1 gp120-mediated CD4 + T cell anergy .
9374446	0	TNF-alpha	0,9	CD4	32,35	TNF-alpha	CD4	7124	920	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|apoptosis apoptosis|nmod|T-lymphocytes T-lymphocytes|nummod|END_ENTITY	TNF-alpha mediated apoptosis of CD4 positive T-lymphocytes .
9826442	0	TNF-alpha	0,9	CD4	67,70	TNF-alpha	CD4	7124	920	Gene	Gene	plays|nsubj|START_ENTITY T|ccomp|plays T|nsubj|END_ENTITY	TNF-alpha , not CD154 -LRB- CD40L -RRB- , plays a major role in SEB-dependent , CD4 -LRB- + -RRB- T cell-induced endothelial cell activation in vitro .
10361238	0	TNF-alpha	66,75	CD8	0,3	TNF-alpha	CD8	7124	925	Gene	Gene	production|appos|START_ENTITY necrosis|dep|production enhancement|nmod|necrosis enhancement|compound|END_ENTITY	CD8 + T cell-mediated enhancement of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- production and HIV-1 LTR-driven gene expression in human monocytic cells is pertussis toxin-sensitive .
11009092	0	TNF-alpha	73,82	CD8	33,36	TNF-alpha	CD8	7124	925	Gene	Gene	thymocytes|nmod|START_ENTITY +|dobj|thymocytes CD4|acl|+ CD4|compound|END_ENTITY	Sex steroids induce apoptosis of CD8 + CD4 + double-positive thymocytes via TNF-alpha .
15922966	0	TNF-alpha	145,154	CD8	31,34	TNF-alpha	CD8	7124	925	Gene	Gene	encoding|dobj|START_ENTITY maturated|xcomp|encoding myeloid|ccomp|maturated myeloid|nsubj|Induction Induction|nmod|cells cells|compound|END_ENTITY	Induction of leukemia-specific CD8 + cytotoxic T cells with autologous myeloid leukemic cells maturated with a fiber-modified adenovirus encoding TNF-alpha .
16210607	0	TNF-alpha	20,29	CD8	64,67	TNF-alpha	CD8	7124	925	Gene	Gene	START_ENTITY|nmod|engagement engagement|nmod|cells cells|compound|END_ENTITY	Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells .
16596274	0	TNF-alpha	33,42	CD8	67,70	TNF-alpha	CD8	7124	925	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of membrane TNF-alpha on activated peripheral CD8 + T cells in systemic_lupus_erythematosus .
1932375	0	TNF-alpha	146,155	CD8	130,133	TNF-alpha	CD8	7124	925	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	Lymphocytes infiltrating ovarian_malignant_ascites : modulation of IL-2-induced proliferation by IL-4 and of selective increase in CD8 + T cells by TNF-alpha .
8476505	0	TNF-alpha	20,29	CD8	60,63	TNF-alpha	CD8	7124	925	Gene	Gene	effect|nmod|START_ENTITY secreted|nsubj|effect secreted|nmod|clone clone|compound|END_ENTITY	Antiviral effect of TNF-alpha and IFN-gamma secreted from a CD8 + influenza virus-specific CTL clone .
10810453	0	TNF-alpha	134,143	COX-2	45,50	TNF-alpha	COX-2	7124	5743	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|stability stability|compound|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
12349897	0	TNF-alpha	29,38	COX-2	124,129	TNF-alpha	COX-2	7124	5743	Gene	Gene	alpha|appos|START_ENTITY alpha|acl|induced induced|ccomp|mediated mediated|nmod|activation activation|nmod|transcription transcription|appos|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
12890694	0	TNF-alpha	117,126	COX-2	66,71	TNF-alpha	COX-2	21926(Tax:10090)	19225(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|induction induction|compound|END_ENTITY	The sphingosine_kinase_1 / sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha .
17117478	0	TNF-alpha	164,173	COX-2	216,221	TNF-alpha	COX-2	21926(Tax:10090)	17709(Tax:10090)	Gene	Gene	release|amod|START_ENTITY suppressing|dobj|release suppressing|nmod|macrophages macrophages|nmod|induction induction|nmod|END_ENTITY	Corticotropin releasing factor receptor 1 -LRB- CRF1 -RRB- and CRF2 agonists exert an anti-inflammatory effect during the early phase of inflammation suppressing LPS-induced TNF-alpha release from macrophages via induction of COX-2 and PGE2 .
19393729	0	TNF-alpha	70,79	COX-2	63,68	TNF-alpha	COX-2	21926(Tax:10090)	17709(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2 , TNF-alpha and iNOS expression , which is mediated by NF-kappaB regulation , in RAW264 .7 cells .
20122965	0	TNF-alpha	12,21	COX-2	43,48	TNF-alpha	COX-2	21926(Tax:10090)	19225(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|upregulation upregulation|compound|END_ENTITY	The role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive_decline induced by beta-amyloid peptide .
8336080	0	TNF-alpha	155,164	CSF-1	115,120	TNF-alpha	CSF-1	21926(Tax:10090)	12977(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Analysis of the synergistic stimulation of mouse macrophage proliferation by macrophage colony-stimulating factor -LRB- CSF-1 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- .
20231691	0	TNF-alpha	144,153	CX3CL1	192,198	TNF-alpha	CX3CL1	7124	6376	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Characterization of synergistic induction of CX3CL1/fractalkine by TNF-alpha and IFN-gamma in vascular endothelial cells : an essential role for TNF-alpha in post-transcriptional regulation of CX3CL1 .
14597565	0	TNF-alpha	14,23	CXCL10	47,53	TNF-alpha	CXCL10	7124	3627	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Regulation of TNF-alpha - and IFN-gamma-induced CXCL10 expression : participation of the airway smooth muscle in the pulmonary inflammatory response in chronic_obstructive_pulmonary_disease .
11146046	0	TNF-alpha	0,9	CXCR4	25,30	TNF-alpha	CXCR4	21926(Tax:10090)	12767(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNF-alpha down-regulates CXCR4 expression in primary murine astrocytes .
12360479	0	TNF-alpha	9,18	Cdx-2	57,62	TNF-alpha	Cdx-2	21926(Tax:10090)	12591(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K , PKB/Akt , and NF-kappaB-dependent pathway .
19809566	0	TNF-alpha	0,9	E-cadherin	24,34	TNF-alpha	E-cadherin	7124	999	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	TNF-alpha downregulates E-cadherin and sensitizes response to y-irradiation in Caco-2 cells .
11123285	0	TNF-alpha	46,55	E-selectin	64,74	TNF-alpha	E-selectin	7124	6401	Gene	Gene	signal|nmod|START_ENTITY induces|nsubj|signal induces|dobj|expression expression|amod|END_ENTITY	Outside-to-inside signal through the membrane TNF-alpha induces E-selectin -LRB- CD62E -RRB- expression on activated human CD4 + T cells .
12119193	0	TNF-alpha	73,82	E-selectin	40,50	TNF-alpha	E-selectin	7124	6401	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Lovastatin-stimulated superinduction of E-selectin , ICAM-1 and VCAM-1 in TNF-alpha activated human vascular endothelial cells .
19878508	0	TNF-alpha	11,20	E-selectin	35,45	TNF-alpha	E-selectin	7124	6401	Gene	Gene	antagonism|amod|START_ENTITY Effects|nmod|antagonism Effects|nmod|END_ENTITY	Effects of TNF-alpha antagonism on E-selectin in obese subjects with metabolic_dysregulation .
7511636	0	TNF-alpha	104,113	E-selectin	130,140	TNF-alpha	E-selectin	21926(Tax:10090)	20339(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY mice|acl|induced transplanted|nmod|mice skin|acl|transplanted recruitment|nmod|skin dependent|nsubj|recruitment dependent|nmod|END_ENTITY	Leukocyte recruitment into human skin transplanted onto severe_combined_immunodeficient mice induced by TNF-alpha is dependent on E-selectin .
9441802	0	TNF-alpha	0,9	E-selectin	57,67	TNF-alpha	E-selectin	7124	6401	Gene	Gene	upregulate|nsubj|START_ENTITY upregulate|dobj|END_ENTITY	TNF-alpha and IL-1 upregulate membrane-bound and soluble E-selectin through a common pathway .
11997234	0	TNF-alpha	51,60	Egr-1	76,81	TNF-alpha	Egr-1	21926(Tax:10090)	13653(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Lipopolysaccharide stimulation of ERK1/2 increases TNF-alpha production via Egr-1 .
20653771	0	TNF-alpha	17,26	Egr-1	71,76	TNF-alpha	Egr-1	7124	1958	Gene	Gene	secretion|amod|START_ENTITY Up-regulation|nmod|secretion mediated|nsubjpass|Up-regulation mediated|nmod|END_ENTITY	Up-regulation of TNF-alpha secretion by cigarette smoke is mediated by Egr-1 in HaCaT human keratinocytes .
9542779	0	TNF-alpha	0,9	Egr-1	43,48	TNF-alpha	Egr-1	7124	1958	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TNF-alpha induces the transcription factor Egr-1 , pro-inflammatory cytokines and cell proliferation in human skin fibroblasts and synovial lining cells .
7547698	0	TNF-alpha	0,9	Fc_epsilon_RII	33,47	TNF-alpha	Fc epsilon RII	7124	2208	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TNF-alpha regulates IL-4-induced Fc_epsilon_RII / CD23 gene expression and soluble Fc_epsilon_RII release by human monocytes .
20173391	0	TNF-alpha	0,9	FoxP3	31,36	TNF-alpha	FoxP3	21926(Tax:10090)	20371(Tax:10090)	Gene	Gene	START_ENTITY|dep|activator activator|nmod|cells cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
9182888	0	TNF-alpha	52,61	GM-CSF	117,123	TNF-alpha	GM-CSF	7124	1437	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	The priming action of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on neutrophils activated by inflammatory microcrystals .
9450626	0	TNF-alpha	118,127	GM-CSF	91,97	TNF-alpha	GM-CSF	7124	1437	Gene	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Modulation of MHC class II + Langerhans cell numbers in corticosteroid treated epidermis by GM-CSF in combination with TNF-alpha .
14687710	0	TNF-alpha	44,53	GRB2	14,18	TNF-alpha	GRB2	7124	2885	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of GRB2 and FLICE2 expression by TNF-alpha in rheumatoid synovium .
12918124	0	TNF-alpha	66,75	HO-1	26,30	TNF-alpha	HO-1	21926(Tax:10090)	15368(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	TLR4 mediates LPS-induced HO-1 expression in mouse liver : role of TNF-alpha and IL-1beta .
10491002	0	TNF-alpha	0,9	ICAM-1	51,57	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	TNF-alpha and IL-1 sequentially induce endothelial ICAM-1 and VCAM-1 expression in MRL/lpr lupus-prone mice .
10837365	0	TNF-alpha	11,20	ICAM-1	38,44	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro .
11247755	0	TNF-alpha	90,99	ICAM-1	23,29	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY improves|nmod|transgenic_mice improves|advcl|Targeted Targeted|dobj|disruption disruption|nmod|END_ENTITY	Targeted disruption of ICAM-1 , P-selectin genes improves cardiac function and survival in TNF-alpha transgenic_mice .
11817671	0	TNF-alpha	92,101	ICAM-1	8,14	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	macrophages|nmod|START_ENTITY macrophages|nsubj|Role Role|nmod|END_ENTITY	Role of ICAM-1 in the aggregation and adhesion of human alveolar macrophages in response to TNF-alpha and INF-gamma .
11888521	0	TNF-alpha	14,23	ICAM-1	32,38	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|dobj|expression expression|amod|END_ENTITY	Inhibition of TNF-alpha induced ICAM-1 , VCAM-1 and E-selectin expression by selenium .
1357985	0	TNF-alpha	23,32	ICAM-1	13,19	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of ICAM-1 by TNF-alpha , IL-1_beta , and LPS in human endothelial cells after downregulation of PKC .
15342194	0	TNF-alpha	117,126	ICAM-1	0,6	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	production|amod|START_ENTITY dependent|nmod|production dependent|nsubj|upregulation upregulation|compound|END_ENTITY	ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-alpha production triggered by the loss of blood-brain barrier integrity .
15656142	0	TNF-alpha	42,51	ICAM-1	53,59	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of shuangshen tongguan -LRB- SSTG -RRB- on TNF-alpha , ICAM-1 during myocardial_ischemia-reperfusion injury -RSB- .
15698778	0	TNF-alpha	37,46	ICAM-1	55,61	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	inhibitors|nmod|START_ENTITY thiocoumarins|nmod|inhibitors induced|nsubj|thiocoumarins induced|dobj|expression expression|compound|END_ENTITY	Novel thiocoumarins as inhibitors of TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells -LRB- HUVECs -RRB- and microsomal lipid peroxidation .
16431966	0	TNF-alpha	29,38	ICAM-1	75,81	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Glucosamine_sulfate inhibits TNF-alpha and IFN-gamma-induced production of ICAM-1 in human retinal pigment epithelial cells in vitro .
16766643	0	TNF-alpha	0,9	ICAM-1	81,87	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY alters|nsubj|activation alters|dobj|distribution distribution|nmod|END_ENTITY	TNF-alpha activation of arterioles and venules alters distribution and levels of ICAM-1 and affects leukocyte-endothelial cell interactions .
17607964	0	TNF-alpha	258,267	ICAM-1	77,83	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	-RSB-|appos|START_ENTITY induced|nmod|-RSB- induced|csubj|-LSB- -LSB-|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
17683945	0	TNF-alpha	98,107	ICAM-1	125,131	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The interaction between myocardial depressant factors in endotoxemic_cardiac_dysfunction : role of TNF-alpha in TLR4-mediated ICAM-1 expression .
18475479	0	TNF-alpha	99,108	ICAM-1	17,23	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|END_ENTITY	Free circulating ICAM-1 in serum and cerebrospinal fluid of HIV-1 infected patients correlate with TNF-alpha and blood-brain barrier damage .
18989464	0	TNF-alpha	79,88	ICAM-1	13,19	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	lingual|nmod|START_ENTITY lingual|nsubj|Induction Induction|nmod|END_ENTITY	Induction of ICAM-1 and VCAM-1 on the mouse lingual lymphatic endothelium with TNF-alpha .
19203796	0	TNF-alpha	57,66	ICAM-1	105,111	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	expression|nmod|START_ENTITY uncouple|dobj|expression uncouple|nmod|cytotoxicity cytotoxicity|acl|associated associated|nmod|END_ENTITY	Lipid rafts uncouple surface expression of transmembrane TNF-alpha from its cytotoxicity associated with ICAM-1 clustering in Raji cells .
19338980	0	TNF-alpha	74,83	ICAM-1	64,70	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|nmod|induction induction|nmod|END_ENTITY	Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha .
19674910	0	TNF-alpha	65,74	ICAM-1	97,103	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	effect|nmod|START_ENTITY effect|acl|induced induced|dobj|expression expression|nmod|END_ENTITY	Inhibitory effect of beta-diketones and their metal complexes on TNF-alpha induced expression of ICAM-1 on human endothelial cells .
19716548	0	TNF-alpha	49,58	ICAM-1	189,195	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	pathway|nmod|START_ENTITY Activation|nmod|pathway suggests|nsubj|Activation suggests|dobj|role role|nmod|TNF_receptor TNF_receptor|appos|END_ENTITY	Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland -LRB- HSG -RRB- cells in vitro , suggests a role for the TNF_receptor -LRB- TNF-R -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in Sj gren 's syndrome-associated autoimmune_sialadenitis .
22574597	0	TNF-alpha	152,161	ICAM-1	163,169	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of yiqi huoxue compound contained drug serum on the expressions of toll-like_receptor_4 and downstream signal transduction pathway , and LOX-1 , TNF-alpha , ICAM-1 in the human vein endothelial cells -RSB- .
24710469	0	TNF-alpha	87,96	ICAM-1	174,180	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	adhesion|nmod|START_ENTITY adhesion|dep|cells cells|acl|suppressing suppressing|dobj|expression expression|amod|END_ENTITY	Rabbit sera containing compound danshen dripping pill attenuate leukocytes adhesion to TNF-alpha -- activated human umbilical vein endothelial cells by suppressing endothelial ICAM-1 and VCAM-1 expression through NF-kappaB signaling pathway .
7729535	0	TNF-alpha	94,103	ICAM-1	17,23	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	presence|nmod|START_ENTITY fibroblasts|nmod|presence fibroblasts|nsubj|Up-regulation Up-regulation|nmod|expression expression|compound|END_ENTITY	Up-regulation of ICAM-1 expression on human dermal fibroblasts by IFN-beta in the presence of TNF-alpha .
7957928	0	TNF-alpha	72,81	ICAM-1	61,67	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	intercellular_adhesion_molecule_1|nmod|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Synergistic activation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- by TNF-alpha and IFN-gamma is mediated by p65/p50 and p65/c-Rel and interferon-responsive factor Stat1 alpha -LRB- p91 -RRB- that can be activated by both IFN-gamma and IFN-alpha .
8530159	0	TNF-alpha	75,84	ICAM-1	35,41	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	sites|compound|START_ENTITY activated|nmod|sites activated|nsubjpass|Intercellular_adhesion_molecule_1 Intercellular_adhesion_molecule_1|appos|END_ENTITY	Intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- is synergistically activated by TNF-alpha and IFN-gamma responsive sites .
8973625	0	TNF-alpha	190,199	ICAM-1	104,110	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|amod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|dep|END_ENTITY	Expression of leucocyte-endothelial adhesion molecules is limited to intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the lung of pneumoconiotic patients : role of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- .
9035283	0	TNF-alpha	89,98	ICAM-1	118,124	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	Inhibition of NF-kappa_B activation by dimethyl_sulfoxide correlates with suppression of TNF-alpha formation , reduced ICAM-1 gene transcription , and protection against endotoxin-induced liver_injury .
9105426	0	TNF-alpha	35,44	ICAM-1	76,82	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	enzymes|nmod|START_ENTITY Role|nmod|enzymes induced|nsubj|Role induced|dobj|expression expression|nmod|END_ENTITY	Role of tyrosine kinase enzymes in TNF-alpha and IL-1 induced expression of ICAM-1 and VCAM-1 on human umbilical vein endothelial cells .
9274840	0	TNF-alpha	52,61	ICAM-1	11,17	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	circulating|dobj|START_ENTITY related|advcl|circulating expression|xcomp|related expression|nsubj|END_ENTITY	Glomerular ICAM-1 expression related to circulating TNF-alpha in human glomerulonephritis .
9378369	0	TNF-alpha	59,68	ICAM-1	28,34	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|increases increases|nmod|mRNA mRNA|compound|END_ENTITY	Hyperoxic increases in lung ICAM-1 mRNA are independent of TNF-alpha and IL-1_beta mRNA .
9521860	0	TNF-alpha	0,9	ICAM-1	57,63	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNF-alpha and 9-cis-retinoic_acid synergistically induce ICAM-1 expression : evidence for interaction of retinoid receptors with NF-kappa_B .
9607608	0	TNF-alpha	40,49	ICAM-1	0,6	TNF-alpha	ICAM-1	7124	3383	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	ICAM-1 and VCAM-1 expression induced by TNF-alpha are inhibited by a glutathione peroxidase mimic .
9973425	0	TNF-alpha	150,159	ICAM-1	40,46	TNF-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role expression|dep|evidence expression|nmod|END_ENTITY	Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice : evidence for a dominant role of TNF-alpha .
19338980	0	TNF-alpha	74,83	IFI16	33,38	TNF-alpha	IFI16	7124	3428	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|compound|END_ENTITY	Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha .
12091360	0	TNF-alpha	87,96	IFN-alpha	27,36	TNF-alpha	IFN-alpha	7124	3439	Gene	Gene	apoptosis|nmod|START_ENTITY induction|nmod|apoptosis involves|dobj|induction involves|nsubj|Response Response|nmod|cells cells|nmod|END_ENTITY	Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion .
16542137	0	TNF-alpha	36,45	IFN-alpha	16,25	TNF-alpha	IFN-alpha	7124	3439	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	Ingested -LRB- oral -RRB- IFN-alpha represses TNF-alpha mRNA in relapsing-remitting_multiple_sclerosis .
17786371	0	TNF-alpha	24,33	IFN-alpha	0,9	TNF-alpha	IFN-alpha	7124	3439	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	IFN-alpha competes with TNF-alpha for STAT-1alpha ; molecular basis for immune escape of human colon_adenocarcinoma COLO 205 cells .
8680797	0	TNF-alpha	22,31	IFN-alpha	68,77	TNF-alpha	IFN-alpha	21926(Tax:10090)	111654(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY Suppressive|dobj|effect Suppressive|nmod|production production|nmod|FdUMP FdUMP|nmod|END_ENTITY	Suppressive effect of TNF-alpha on increased production of FdUMP by IFN-alpha .
9661265	0	TNF-alpha	61,70	IFN-alpha	39,48	TNF-alpha	IFN-alpha	397086(Tax:9823)	100310804(Tax:9823)	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Evaluation of various cytokines -LRB- IL-6 , IFN-alpha , IFN-gamma , TNF-alpha -RRB- as markers for acute bacterial_infection in swine -- a possible role for serum interleukin-6 .
10030838	0	TNF-alpha	37,46	IFN-gamma	0,9	TNF-alpha	IFN-gamma	24835(Tax:10116)	25712(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY potentiates|dobj|release potentiates|nsubj|END_ENTITY	IFN-gamma potentiates the release of TNF-alpha and MIP-1alpha by alveolar macrophages during allergic_reactions .
10193415	0	TNF-alpha	115,124	IFN-gamma	70,79	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
10505975	0	TNF-alpha	153,162	IFN-gamma	57,66	TNF-alpha	IFN-gamma	24835(Tax:10116)	25712(Tax:10116)	Gene	Gene	affected|nmod|START_ENTITY activation|parataxis|affected activation|nmod|END_ENTITY	Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages : CIITA promoter activation is not affected by TNF-alpha .
10510366	0	TNF-alpha	78,87	IFN-gamma	103,112	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	enhancement|amod|START_ENTITY enhancement|nmod|production production|amod|END_ENTITY	A soluble factor produced by lamina propria mononuclear cells is required for TNF-alpha enhancement of IFN-gamma production by T cells .
11130781	0	TNF-alpha	93,102	IFN-gamma	28,37	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	manner|amod|START_ENTITY cells|nmod|manner hepatocyte|appos|cells primed|dobj|hepatocyte END_ENTITY|acl|primed	LPS induces direct death of IFN-gamma primed murine embryonic hepatocyte , BNL_CL2 cells in a TNF-alpha independent manner .
11737065	0	TNF-alpha	26,35	IFN-gamma	0,9	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	IFN-gamma synergizes with TNF-alpha but not with viable H. _ pylori in up-regulating CXC chemokine secretion in gastric epithelial cells .
12950679	0	TNF-alpha	50,59	IFN-gamma	61,70	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	IL-12|appos|START_ENTITY CD40L|appos|IL-12 END_ENTITY|nsubj|CD40L	In situ expression of CD40 , CD40L -LRB- CD154 -RRB- , IL-12 , TNF-alpha , IFN-gamma and TGF-beta1 in murine lungs during slowly progressive primary_tuberculosis .
1436241	0	TNF-alpha	44,53	IFN-gamma	21,30	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	IFN-alpha|dep|START_ENTITY IFN-alpha|dep|END_ENTITY	Cytokine -LRB- IFN-alpha , IFN-gamma , IL-1-alpha , TNF-alpha -RRB- - induced modulation of HLA cell surface expression in human breast_cancer cell lines .
15699106	0	TNF-alpha	14,23	IFN-gamma	43,52	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of TNF-alpha gene expression by IFN-gamma and pamidronate in murine macrophages : regulation by STAT1-dependent pathways .
15790516	0	TNF-alpha	42,51	IFN-gamma	0,9	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY macrophages|nmod|expression macrophages|nsubj|primes primes|amod|END_ENTITY	IFN-gamma primes macrophages for enhanced TNF-alpha expression in response to stimulatory and non-stimulatory amounts of microparticulate beta-glucan .
15806975	0	TNF-alpha	109,118	IFN-gamma	68,77	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY interferon-gamma|appos|tumor_necrosis_factor-alpha interferon-gamma|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
16258194	0	TNF-alpha	16,25	IFN-gamma	27,36	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	IL-17|compound|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16332515	0	TNF-alpha	38,47	IFN-gamma	14,23	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Modulation of IFN-gamma production by TNF-alpha in macrophages from the tumor environment : significance as an angiogenic switch .
16513426	0	TNF-alpha	41,50	IFN-gamma	30,39	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	IL-5|appos|START_ENTITY IL-5|appos|END_ENTITY	Evaluation of cytokines -LRB- MIG , IFN-gamma , TNF-alpha , IL-4 , IL-5 , and IL-10 -RRB- during the different evolutive phases of chagasic esophagopathy .
17101606	0	TNF-alpha	71,80	IFN-gamma	50,59	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	depends|nmod|START_ENTITY depends|nsubj|Regulation Regulation|nmod|synthesis synthesis|nmod|wounds wounds|nmod|END_ENTITY	Regulation of nitric_oxide synthesis in wounds by IFN-gamma depends on TNF-alpha .
17273910	0	TNF-alpha	16,25	IFN-gamma	40,49	TNF-alpha	IFN-gamma	403922(Tax:9615)	403801(Tax:9615)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Upregulation of TNF-alpha production by IFN-gamma and LPS in cultured canine keratinocytes : application to monosaccharides effects .
17786499	0	TNF-alpha	81,90	IFN-gamma	92,101	TNF-alpha	IFN-gamma	24835(Tax:10116)	25712(Tax:10116)	Gene	Gene	bFGF|appos|START_ENTITY bFGF|appos|END_ENTITY	Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta , TNF-alpha , IFN-gamma , TGF-beta , bFGF , and PDGF in rat 's gingiva .
17928538	0	TNF-alpha	50,59	IFN-gamma	0,9	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	effects|nmod|START_ENTITY mimic|dobj|effects mimic|nsubj|END_ENTITY	IFN-gamma does not mimic the catabolic effects of TNF-alpha .
19802480	0	TNF-alpha	42,51	IFN-gamma	53,62	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	IgG|amod|START_ENTITY IgG|amod|END_ENTITY	-LSB- Association between the plasma levels of TNF-alpha , IFN-gamma , IL-10 , nitric_oxide and specific IgG isotypes in the clinical forms of chronic Chagas_disease -RSB- .
20364089	0	TNF-alpha	73,82	IFN-gamma	63,72	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	lymphocytes|compound|START_ENTITY lymphocytes|compound|END_ENTITY	Control_of_vaccinia_virus skin_lesions by long-term-maintained IFN-gamma + TNF-alpha + effector/memory CD4 + lymphocytes in humans .
2117000	0	TNF-alpha	39,48	IFN-gamma	50,59	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	IL-1|dep|START_ENTITY IL-1|dep|END_ENTITY	Effects of associated cytokines -LRB- IL-1 , TNF-alpha , IFN-gamma and TGF-beta -RRB- on collagen and glycosaminoglycan production by cultured human synovial cells .
2118480	0	TNF-alpha	69,78	IFN-gamma	97,106	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|acl|inhibition inhibition|nmod|END_ENTITY	Priming the macrophage respiratory burst with IL-4 : enhancement with TNF-alpha but inhibition by IFN-gamma .
21591983	0	TNF-alpha	17,26	IFN-gamma	53,62	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	GPIA|compound|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
2475518	0	TNF-alpha	73,82	IFN-gamma	29,38	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Effects of interferon-gamma -LRB- IFN-gamma -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on the expression of LFA-1 in the moderate phenotype of leukocyte_adhesion_deficiency -LRB- LAD -RRB- .
3131759	0	TNF-alpha	84,93	IFN-gamma	117,126	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY tumor_necrosis_factor-alpha|appos|END_ENTITY	Antiproliferative effects exerted by recombinant human tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- on human pancreatic_tumor cell lines .
3141050	0	TNF-alpha	71,80	IFN-gamma	102,111	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	Synergistic enhancement of the antitumor activity of recombinant human TNF-alpha by recombinant human IFN-gamma .
7544321	0	TNF-alpha	109,118	IFN-gamma	37,46	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY promote|dobj|synthesis synergizes|xcomp|promote synergizes|nmod|IL-2 IL-2|compound|END_ENTITY	Tumor-derived factor synergizes with IFN-gamma and LPS , IL-2 or TNF-alpha to promote macrophage synthesis of TNF-alpha and TNF_receptors for autocrine induction of nitric_oxide synthase and enhanced nitric_oxide-mediated tumor_cytotoxicity .
7636207	0	TNF-alpha	74,83	IFN-gamma	34,43	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes .
7683323	1	TNF-alpha	221,230	IFN-gamma	189,198	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	MIF and IFN-gamma synergize with lipid_A to mediate migration inhibition but only IFN-gamma induces production of TNF-alpha and nitric_oxide .
8029644	0	TNF-alpha	145,154	IFN-gamma	0,9	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY induced|dobj|release down-regulates|acl|induced internalization|dep|down-regulates internalization|amod|END_ENTITY	IFN-gamma inhibits internalization of soluble aminated beta-1 ,3 - D-glucan by macrophages and thereby down-regulates the glucan induced release of TNF-alpha and IL-1_beta .
8038591	0	TNF-alpha	76,85	IFN-gamma	106,115	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|interferon-gamma interferon-gamma|appos|END_ENTITY	Isolated perfusion of the limb with high-dose tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , interferon-gamma -LRB- IFN-gamma -RRB- and melphalan for melanoma stage III .
8038594	0	TNF-alpha	117,126	IFN-gamma	161,170	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|melphalan melphalan|appos|END_ENTITY	Treatment of in-transit metastases from cutaneous melanoma by isolation perfusion with tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , melphalan and interferon-gamma -LRB- IFN-gamma -RRB- .
8666424	0	TNF-alpha	38,47	IFN-gamma	27,36	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	IL-4|compound|START_ENTITY END_ENTITY|dep|IL-4	Effect of human cytokines -LRB- IFN-gamma , TNF-alpha , IL-1_beta , IL-4 -RRB- on porcine endothelial cells : induction of MHC and adhesion molecules and functional significance of these changes .
8831687	0	TNF-alpha	0,9	IFN-gamma	46,55	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|liver liver|nmod|mouse mouse|amod|END_ENTITY	TNF-alpha gene expression in the liver of the IFN-gamma transgenic mouse with chronic_active_hepatitis .
8973622	0	TNF-alpha	201,210	IFN-gamma	234,243	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	Raised anti-endothelial cell autoantibodies -LRB- AECA -RRB- , but not anti-neutrophil cytoplasmic autoantibodies -LRB- ANCA -RRB- , in recurrent oral ulceration : modulation of AECA binding by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- .
9069539	0	TNF-alpha	164,173	IFN-gamma	139,148	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Enhancement Enhancement|nmod|activity activity|nmod|clofazimine clofazimine|nmod|infection infection|acl|induced induced|nmod|END_ENTITY	Enhancement of antibacterial activity of clofazimine against Mycobacterium_avium-Mycobacterium_intracellulare complex infection induced by IFN-gamma is mediated by TNF-alpha .
9378494	0	TNF-alpha	182,191	IFN-gamma	143,152	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	involvement|nmod|START_ENTITY involvement|amod|END_ENTITY	Generation of dendritic cells from bone marrow progenitors using GM-CSF , TNF-alpha , and additional cytokines : antagonistic effects of IL-4 and IFN-gamma and selective involvement of TNF-alpha receptor-1 .
9379667	0	TNF-alpha	100,109	IFN-gamma	111,120	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	-LSB- Concentration of selected cytokines in subretinal fluid in patients with retinal_detachment -LRB- IL-8 , TNF-alpha , IFN-gamma -RRB- -RSB- .
9472684	0	TNF-alpha	83,92	IFN-gamma	119,128	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	and/or|appos|START_ENTITY Apoptosis|nmod|and/or Apoptosis|amod|interferon-gamma interferon-gamma|dep|END_ENTITY	Apoptosis of colorectal_adenocarcinoma -LRB- COLO 201 -RRB- by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and/or interferon-gamma -LRB- IFN-gamma -RRB- , resulting from down-modulation of Bcl-2 expression .
9541578	0	TNF-alpha	18,27	IFN-gamma	132,141	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	prerequisite|nsubj|START_ENTITY prerequisite|nmod|production production|nmod|nitric_oxide nitric_oxide|acl|generated generated|nmod|END_ENTITY	IFN-gamma-induced TNF-alpha is a prerequisite for in vitro production of nitric_oxide generated in murine peritoneal macrophages by IFN-gamma .
9566791	0	TNF-alpha	219,228	IFN-gamma	174,183	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Differential potentiation of anti-mycobacterial activity and reactive nitrogen intermediate-producing ability of murine peritoneal macrophages activated by interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- .
9570555	0	TNF-alpha	104,113	IFN-gamma	188,197	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY plays|advcl|maintaining maintaining|nmod|absence absence|nmod|END_ENTITY	Factors involved in regulating primary and secondary immunity to infection with Histoplasma_capsulatum : TNF-alpha plays a critical role in maintaining secondary immunity in the absence of IFN-gamma .
9631453	0	TNF-alpha	58,67	IFN-gamma	0,9	TNF-alpha	IFN-gamma	24835(Tax:10116)	25712(Tax:10116)	Gene	Gene	triggered|nmod|START_ENTITY triggered|nsubj|production production|amod|END_ENTITY	IFN-gamma production of adult rat astrocytes triggered by TNF-alpha .
9649226	0	TNF-alpha	114,123	IFN-gamma	147,156	TNF-alpha	IFN-gamma	7124	3458	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	Detection of Fcgamma receptors on human endothelial cells stimulated with cytokines tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- .
9766626	0	TNF-alpha	135,144	IFN-gamma	73,82	TNF-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY LPS|dep|role LPS|compound|END_ENTITY	Ionizing radiation potentiates the induction of nitric_oxide_synthase by IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha .
18802049	0	TNF-alpha	18,27	IFN-gamma-induced	0,17	TNF-alpha	IFN-gamma-induced	21926(Tax:10090)	56045(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	IFN-gamma-induced TNF-alpha expression is regulated by interferon_regulatory_factors_1_and_8 in mouse macrophages .
10528210	0	TNF-alpha	119,128	IL-1	0,4	TNF-alpha	IL-1	21926(Tax:10090)	111343(Tax:10090)	Gene	Gene	blockade|amod|START_ENTITY ameliorates|nsubj|blockade prevents|advcl|ameliorates prevents|nsubj|blockade blockade|amod|alpha alpha|dep|END_ENTITY	IL-1 alpha beta blockade prevents cartilage and bone_destruction in murine type II collagen-induced arthritis , whereas TNF-alpha blockade only ameliorates joint inflammation .
11673538	0	TNF-alpha	0,9	IL-1	55,59	TNF-alpha	IL-1	21926(Tax:10090)	111343(Tax:10090)	Gene	Gene	compensates|nsubj|START_ENTITY compensates|nmod|defense defense|nmod|mice mice|compound|END_ENTITY	TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal_pneumonia .
11743653	0	TNF-alpha	29,38	IL-1	40,44	TNF-alpha	IL-1	21926(Tax:10090)	111343(Tax:10090)	Gene	Gene	roles|appos|START_ENTITY roles|appos|END_ENTITY	Discrete roles of cytokines , TNF-alpha , IL-1 , IL-6 in tumor promotion and cell transformation .
11895541	0	TNF-alpha	58,67	IL-1	53,57	TNF-alpha	IL-1	7124	3552	Gene	Gene	inhibition|amod|START_ENTITY assessment|dep|inhibition assessment|nmod|END_ENTITY	Clinical , radiographic and biochemical assessment of IL-1 / TNF-alpha antagonist inhibition of bone_loss in experimental periodontitis .
12235693	0	TNF-alpha	119,128	IL-1	82,86	TNF-alpha	IL-1	7124	3552	Gene	Gene	factor|acl|START_ENTITY factor|compound|END_ENTITY	-LSB- Effect of antibiotic therapy on levels of proinflammatory cytokines : interleukin IL-1 , IL-6 and tumor necrosis factor TNF-alpha in serum of patients with Lyme_borreliosis -RSB- .
1337985	0	TNF-alpha	93,102	IL-1	0,4	TNF-alpha	IL-1	7124	3552	Gene	Gene	lymphotoxin|compound|START_ENTITY mediated|nmod|lymphotoxin mediated|nsubjpass|synergy synergy|compound|END_ENTITY	IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-alpha and beta -LRB- lymphotoxin -RRB- .
16365459	0	TNF-alpha	114,123	IL-1	109,113	TNF-alpha	IL-1	7124	3552	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1 / TNF-alpha production .
17703191	0	TNF-alpha	49,58	IL-1	61,65	TNF-alpha	IL-1	21926(Tax:10090)	111343(Tax:10090)	Gene	Gene	termination|nmod|START_ENTITY termination|amod|END_ENTITY	Essential role for TAX1BP1 in the termination of TNF-alpha - , IL-1 - and LPS-mediated NF-kappaB and JNK signaling .
1906501	0	TNF-alpha	54,63	IL-1	49,53	TNF-alpha	IL-1	7124	3553	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	An NF-kappa_B-like transcription factor mediates IL-1 / TNF-alpha induction of gro in human fibroblasts .
8175024	0	TNF-alpha	71,80	IL-1	152,156	TNF-alpha	IL-1	7124	3552	Gene	Gene	Transfection|appos|START_ENTITY antisense|nsubj|Transfection antisense|ccomp|abolishes abolishes|dobj|response response|nmod|_ _|appos|END_ENTITY	Transfection of ovarian_cancer cells with tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- antisense mRNA abolishes the proliferative response to interleukin-1 _ -LRB- IL-1 -RRB- but not TNF-alpha .
9103454	0	TNF-alpha	0,9	IL-1	91,95	TNF-alpha	IL-1	7124	3553	Gene	Gene	induces|advmod|START_ENTITY induces|dobj|release release|nmod|receptor receptor|amod|type type|dep|END_ENTITY	TNF-alpha , unlike other pro- and anti-inflammatory cytokines , induces rapid release of the IL-1 type II decoy receptor in human myelomonocytic cells .
21173731	0	TNF-alpha	6,15	IL-1-beta	17,26	TNF-alpha	IL-1-beta	7124	3553	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	IL-6 , TNF-alpha , IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions .
10222054	0	TNF-alpha	26,35	IL-10	67,72	TNF-alpha	IL-10	7124	3586	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Preferential induction of TNF-alpha and IL-1beta and inhibition of IL-10 secretion by human peripheral blood monocytes by synthetic aza-alkyl_lysophospholipids .
11034403	0	TNF-alpha	56,65	IL-10	27,32	TNF-alpha	IL-10	7124	3586	Gene	Gene	induction|amod|START_ENTITY concomitant|nmod|induction concomitant|compound|END_ENTITY	Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock_protein_27 -LRB- Hsp27 -RRB- suggests Hsp27 is primarily an antiinflammatory stimulus .
11758205	0	TNF-alpha	50,59	IL-10	66,71	TNF-alpha	IL-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|mRNA mRNA|compound|END_ENTITY	-LSB- Apoptosis of pancreatic acinar and expression of TNF-alpha mRNA , IL-10 mRNA in rats with acute pancreatitis -RSB- .
11991675	0	TNF-alpha	21,30	IL-10	14,19	TNF-alpha	IL-10	7124	3586	Gene	Gene	IFN-gamma|appos|START_ENTITY IFN-gamma|compound|END_ENTITY	Production of IL-10 , TNF-alpha , IFN-gamma , TGF-beta1 by different populations of erythroid cells derived from human embryonal liver .
11994432	0	TNF-alpha	55,64	IL-10	34,39	TNF-alpha	IL-10	7124	3586	Gene	Gene	production|amod|START_ENTITY suppression|nmod|production suppression|compound|END_ENTITY	Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa_B in primary human macrophages .
11997699	0	TNF-alpha	83,92	IL-10	17,22	TNF-alpha	IL-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	release|amod|START_ENTITY regulator|nmod|release induces|nmod|regulator induces|dobj|production production|compound|END_ENTITY	Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release .
12759436	0	TNF-alpha	69,78	IL-10	22,27	TNF-alpha	IL-10	7124	3586	Gene	Gene	production|amod|START_ENTITY inhibition|nmod|production affect|dobj|inhibition affect|nsubj|variants variants|nmod|receptor receptor|compound|END_ENTITY	Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production .
12847222	0	TNF-alpha	113,122	IL-10	148,153	TNF-alpha	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY injury|nmod|presence mice|nmod|injury resistance|nmod|mice mediated|nsubjpass|resistance mediated|nmod|END_ENTITY	Increased resistance of LFA-1-deficient mice to lipopolysaccharide-induced shock/liver _ injury in the presence of TNF-alpha and IL-12 is mediated by IL-10 : a novel role for LFA-1 in the regulation of the proinflammatory and anti-inflammatory cytokine balance .
14707076	0	TNF-alpha	83,92	IL-10	0,5	TNF-alpha	IL-10	7124	3586	Gene	Gene	form|nmod|START_ENTITY up-regulation|nmod|form apoptosis|nmod|up-regulation induces|dobj|apoptosis induces|nsubj|END_ENTITY	IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha .
15298427	0	TNF-alpha	102,111	IL-10	125,130	TNF-alpha	IL-10	7124	3586	Gene	Gene	effects|nmod|START_ENTITY reaction|dep|effects reaction|amod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
15603866	0	TNF-alpha	0,9	IL-10	21,26	TNF-alpha	IL-10	7124	3586	Gene	Gene	IL-6|compound|START_ENTITY IL-6|appos|END_ENTITY	TNF-alpha , TGF-beta , IL-10 , IL-6 , and INF-gamma alleles among African Americans and Cuban Americans .
15622443	0	TNF-alpha	0,9	IL-10	22,27	TNF-alpha	IL-10	7124	3586	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|IL-6 IL-6|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
15652410	0	TNF-alpha	51,60	IL-10	125,130	TNF-alpha	IL-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	independent|amod|START_ENTITY independent|nmod|increase increase|nmod|production production|compound|END_ENTITY	Acute stress suppresses pro-inflammatory cytokines TNF-alpha and IL-1_beta independent of a catecholamine-driven increase in IL-10 production .
15848524	0	TNF-alpha	46,55	IL-10	63,68	TNF-alpha	IL-10	7124	3586	Gene	Gene	START_ENTITY|dep|MCP-1 MCP-1|dep|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
16781693	0	TNF-alpha	116,125	IL-10	135,140	TNF-alpha	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|dep|END_ENTITY	Phagocytosis of N-acetyl-D-glucosamine particles , a Th1 adjuvant , by RAW 264.7 cells results in MAPK activation and TNF-alpha , but not IL-10 , production .
16935932	0	TNF-alpha	14,23	IL-10	61,66	TNF-alpha	IL-10	7124	3586	Gene	Gene	destabilization|amod|START_ENTITY mediated|nsubjpass|destabilization mediated|nmod|suppression suppression|compound|END_ENTITY	IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression .
17483704	0	TNF-alpha	0,9	IL-10	27,32	TNF-alpha	IL-10	7124	3586	Gene	Gene	PECAM-1|compound|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
19026560	0	TNF-alpha	92,101	IL-10	0,5	TNF-alpha	IL-10	7124	3586	Gene	Gene	affects|nmod|START_ENTITY affects|nsubj|overexpression overexpression|compound|END_ENTITY	IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro .
19097804	0	TNF-alpha	59,68	IL-10	53,58	TNF-alpha	IL-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Endurance training induces depot-specific changes in IL-10 / TNF-alpha ratio in rat adipose tissue .
19706021	0	TNF-alpha	21,30	IL-10	65,70	TNF-alpha	IL-10	7124	3586	Gene	Gene	levels|amod|START_ENTITY circulating|dobj|levels Maternal|acl|circulating correlated|nsubj|Maternal correlated|nmod|levels levels|compound|END_ENTITY	Maternal circulating TNF-alpha levels are highly correlated with IL-10 levels , but not IL-6 and IL-8 levels , in women with pre-eclampsia .
19948415	0	TNF-alpha	32,41	IL-10	26,31	TNF-alpha	IL-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY ratio|dep|END_ENTITY	Exercise training changes IL-10 / TNF-alpha ratio in the skeletal muscle of post-MI rats .
20055787	0	TNF-alpha	26,35	IL-10	37,42	TNF-alpha	IL-10	7124	3586	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
21591983	0	TNF-alpha	17,26	IL-10	40,45	TNF-alpha	IL-10	7124	3586	Gene	Gene	GPIA|compound|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
7636207	0	TNF-alpha	74,83	IL-10	14,19	TNF-alpha	IL-10	7124	3586	Gene	Gene	transcription|nmod|START_ENTITY Inhibition|nmod|transcription Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of IL-10 expression by IFN-gamma up-regulates transcription of TNF-alpha in human monocytes .
7897221	1	TNF-alpha	119,128	IL-10	163,168	TNF-alpha	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	release|amod|START_ENTITY release|nmod|mechanism mechanism|acl|involving involving|dobj|END_ENTITY	Colon-26-derived prostaglandin_E2 inhibits TNF-alpha release via a mechanism involving IL-10 .
8195696	0	TNF-alpha	27,36	IL-10	93,98	TNF-alpha	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY determining|nsubj|effects determining|nmod|ability ability|nmod|END_ENTITY	The cooperative effects of TNF-alpha and IFN-gamma are determining factors in the ability of IL-10 to protect mice from lethal endotoxemia .
8543841	0	TNF-alpha	22,31	IL-10	0,5	TNF-alpha	IL-10	7124	3586	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte/macrophage lineage .
8708914	0	TNF-alpha	34,43	IL-10	6,11	TNF-alpha	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|therapy therapy|compound|END_ENTITY	Viral IL-10 gene therapy inhibits TNF-alpha and IL-1_beta , not IL-6 , in the newborn endotoxemic mouse .
8711645	0	TNF-alpha	67,76	IL-10	16,21	TNF-alpha	IL-10	7124	3586	Gene	Gene	necrosis|dep|START_ENTITY necrosis|nsubj|regulation regulation|appos|END_ENTITY	Interleukin_10 -LRB- IL-10 -RRB- regulation of tumour necrosis factor alpha -LRB- TNF-alpha -RRB- from human alveolar macrophages and peripheral blood monocytes .
8777273	0	TNF-alpha	30,39	IL-10	0,5	TNF-alpha	IL-10	7124	3586	Gene	Gene	synergize|nmod|START_ENTITY synergize|nsubj|END_ENTITY	IL-10 and IL-4 synergize with TNF-alpha to induce IL-1ra production by human neutrophils .
9103430	0	TNF-alpha	82,91	IL-10	40,45	TNF-alpha	IL-10	7124	3586	Gene	Gene	role|nmod|START_ENTITY production|dep|role production|compound|END_ENTITY	Contact with T cells modulates monocyte IL-10 production : role of T cell membrane TNF-alpha .
9191887	0	TNF-alpha	169,178	IL-10	155,160	TNF-alpha	IL-10	7124	3586	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9300685	0	TNF-alpha	153,162	IL-10	120,125	TNF-alpha	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY association|nmod|levels association|nmod|inhibition inhibition|compound|END_ENTITY	Delay in the onset of systemic_lupus_erythematosus following treatment with the immunomodulator AS101 : association with IL-10 inhibition and increase in TNF-alpha levels .
9328122	0	TNF-alpha	71,80	IL-10	16,21	TNF-alpha	IL-10	7124	3586	Gene	Gene	receptors|appos|START_ENTITY necrosis|dobj|receptors necrosis|nsubj|levels levels|nmod|tumour tumour|amod|END_ENTITY	Serum levels of IL-10 , IL-15 and soluble tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- receptors in type C chronic liver_disease .
9415530	0	TNF-alpha	44,53	IL-10	19,24	TNF-alpha	IL-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Gene expression of IL-10 in relationship to TNF-alpha , IL-1beta and IL-2 in the rat brain following middle_cerebral_artery_occlusion .
21402950	0	TNF-alpha	0,9	IL-17A	65,71	TNF-alpha	IL-17A	21926(Tax:10090)	16171(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TNF-alpha from inflammatory dendritic cells -LRB- DCs -RRB- regulates lung IL-17A / IL-5 levels and neutrophilia versus eosinophilia during persistent fungal_infection .
12684057	0	TNF-alpha	0,9	IL-18	26,31	TNF-alpha	IL-18	7124	3606	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	TNF-alpha and H2O2 induce IL-18 and IL-18R_beta expression in cardiomyocytes via NF-kappa_B activation .
12370360	0	TNF-alpha	85,94	IL-19	0,5	TNF-alpha	IL-19	21926(Tax:10090)	329244(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha .
16778150	0	TNF-alpha	83,92	IL-19	31,36	TNF-alpha	IL-19	7124	29949	Gene	Gene	increase|amod|START_ENTITY resulting|nmod|increase induce|xcomp|resulting induce|xcomp|END_ENTITY	A2B adenosine receptors induce IL-19 from bronchial epithelial cells , resulting in TNF-alpha increase .
10528667	0	TNF-alpha	63,72	IL-1Ra	82,88	TNF-alpha	IL-1Ra	7124	3557	Gene	Gene	IL-1beta|appos|START_ENTITY IL-1beta|appos|END_ENTITY	Whole blood production of monocytic cytokines -LRB- IL-1beta , IL-6 , TNF-alpha , sIL-6R , IL-1Ra -RRB- in haemodialysed patients .
12954239	0	TNF-alpha	49,58	IL-1_alpha	31,41	TNF-alpha	IL-1 alpha	280943(Tax:9913)	281250(Tax:9913)	Gene	Gene	IFN-gamma|compound|START_ENTITY END_ENTITY|dep|IFN-gamma	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
1793017	0	TNF-alpha	122,131	IL-1_alpha	83,93	TNF-alpha	IL-1 alpha	7124	3552	Gene	Gene	factor|appos|START_ENTITY necrosis|dobj|factor necrosis|nsubj|Development Development|nmod|assays assays|nmod|END_ENTITY	Development of high-throughput radioligand binding assays for interleukin-1_alpha -LRB- IL-1_alpha -RRB- and tumor necrosis factor -LRB- TNF-alpha -RRB- in isolated membrane preparations .
7759886	0	TNF-alpha	78,87	IL-1_alpha	66,76	TNF-alpha	IL-1 alpha	24835(Tax:10116)	24493(Tax:10116)	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|nmod|monocyte monocyte|acl|migration migration|nmod|reactions reactions|appos|END_ENTITY	In vivo blood monocyte migration to acute inflammatory reactions , IL-1_alpha , TNF-alpha , IFN-gamma , and C5a utilizes LFA-1 , Mac-1 , and VLA-4 .
8006453	0	TNF-alpha	89,98	IL-1_alpha	45,55	TNF-alpha	IL-1 alpha	7124	3552	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Differential effects of interleukin_1-alpha -LRB- IL-1_alpha -RRB- or tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on motility of human melanoma cell lines on fibronectin .
8186322	0	TNF-alpha	113,122	IL-1_alpha	14,24	TNF-alpha	IL-1 alpha	7124	3552	Gene	Gene	gene|nmod|START_ENTITY activation|nmod|gene Regulation|dep|activation Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-1_alpha expression in human keratinocytes : transcriptional activation of the IL-1_alpha gene by TNF-alpha , LPS , and IL-1_alpha .
8186322	0	TNF-alpha	113,122	IL-1_alpha	94,104	TNF-alpha	IL-1 alpha	7124	3552	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of IL-1_alpha expression in human keratinocytes : transcriptional activation of the IL-1_alpha gene by TNF-alpha , LPS , and IL-1_alpha .
8928088	0	TNF-alpha	0,9	IL-1_alpha	21,31	TNF-alpha	IL-1 alpha	7124	3552	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|upregulation upregulation|amod|END_ENTITY	TNF-alpha suppresses IL-1_alpha and IL-6 upregulation of C4b-binding_protein in HepG-2 hepatoma cells .
10540185	0	TNF-alpha	60,69	IL-1_beta	72,81	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	alpha|appos|START_ENTITY levels|nmod|alpha levels|appos|IL-2_receptor IL-2_receptor|amod|END_ENTITY	Perioperative serum levels of tumour-necrosis-factor alpha -LRB- TNF-alpha -RRB- , IL-1_beta , IL-6 , IL-10 and soluble IL-2_receptor in patients undergoing cardiac surgery with cardiopulmonary bypass without and with correction for haemodilution .
10810453	0	TNF-alpha	134,143	IL-1_beta	90,99	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|stability stability|nmod|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
1443236	0	TNF-alpha	22,31	IL-1_beta	56,65	TNF-alpha	IL-1 beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY attenuates|nsubj|injection attenuates|dobj|fever fever|amod|END_ENTITY	Systemic injection of TNF-alpha attenuates fever due to IL-1_beta and LPS in rats .
1633263	0	TNF-alpha	23,32	IL-1_beta	34,43	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	production|nmod|START_ENTITY undergoing|nmod|production undergoing|nsubj|END_ENTITY	In vitro production of TNF-alpha , IL-1_beta and IL-6 by mononuclear blood cells of patients with renal_cell_carcinoma undergoing rIL-2 treatment .
1768736	0	TNF-alpha	20,29	IL-1_beta	39,48	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nsubj|release	Enhanced release of TNF-alpha , but not IL-1_beta , from uremic blood after endotoxin stimulation .
17901573	0	TNF-alpha	107,116	IL-1_beta	118,127	TNF-alpha	IL-1 beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|amod|IL-6 IL-6|amod|END_ENTITY	Influence of enalapril , quinapril and losartan on lipopolysaccharide -LRB- LPS -RRB- - induced serum concentrations of TNF-alpha , IL-1_beta , IL-6 in spontaneously hypertensive rats -LRB- SHR -RRB- .
7515924	1	TNF-alpha	158,167	IL-1_beta	214,223	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	Down-regulation|nmod|START_ENTITY paralleled|nsubjpass|Down-regulation paralleled|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Down-regulation of TNF-alpha and IL-6 is paralleled by an up-regulation of IL-1_beta and granulocyte_colony-stimulating_factor expression .
7608561	0	TNF-alpha	92,101	IL-1_beta	79,88	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	required|nmod|START_ENTITY required|nmod|induction induction|nmod|END_ENTITY	A cyclic_adenosine_3 ' ,5 ' - monophosphate signal is required for the induction of IL-1_beta by TNF-alpha in human monocytes .
7681094	0	TNF-alpha	29,38	IL-1_beta	48,57	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	production|amod|START_ENTITY production|dep|END_ENTITY	Inflammatory fluids regulate TNF-alpha , but not IL-1_beta , production by human peritoneal macrophages .
7921752	0	TNF-alpha	23,32	IL-1_beta	34,43	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Serum cytokines -LRB- IL-6 , TNF-alpha , IL-1_beta and IFN-gamma -RRB- in ankylosing_spondylitis : a close correlation between serum IL-6 and disease activity and severity .
7948748	0	TNF-alpha	0,9	IL-1_beta	62,71	TNF-alpha	IL-1 beta	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	potentiate|nsubj|START_ENTITY potentiate|dobj|effects effects|nmod|islets islets|amod|END_ENTITY	TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1_beta on mouse pancreatic islets mainly via generation of nitric_oxide .
8189655	0	TNF-alpha	124,133	IL-1_beta	58,67	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	-LSB- Serum levels and gene expressions of interleukin-1_beta -LRB- IL-1_beta -RRB- , interleukin-6 -LRB- IL-6 -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human renal_cell_carcinomas -RSB- .
8260601	0	TNF-alpha	85,94	IL-1_beta	96,105	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	START_ENTITY|appos|production production|amod|END_ENTITY	Antilipid a monoclonal antibody HA-1A : immune complex clearance of endotoxin reduces TNF-alpha , IL-1_beta and IL-6 production .
8370177	0	TNF-alpha	65,74	IL-1_beta	15,24	TNF-alpha	IL-1 beta	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	factor-alpha|appos|START_ENTITY necrosis|dobj|factor-alpha necrosis|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of IL-1_beta , IL-6 and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- in human T cells activated by murine antigens .
8455368	0	TNF-alpha	22,31	IL-1_beta	33,42	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	production|nmod|START_ENTITY glomerulonephritis|nmod|production glomerulonephritis|nsubj|END_ENTITY	In situ production of TNF-alpha , IL-1_beta and IL-2R in ANCA-positive glomerulonephritis .
8666424	0	TNF-alpha	38,47	IL-1_beta	49,58	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	IL-4|compound|START_ENTITY IL-4|dep|END_ENTITY	Effect of human cytokines -LRB- IFN-gamma , TNF-alpha , IL-1_beta , IL-4 -RRB- on porcine endothelial cells : induction of MHC and adhesion molecules and functional significance of these changes .
9191887	0	TNF-alpha	169,178	IL-1_beta	138,147	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|compound|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9227316	0	TNF-alpha	83,92	IL-1_beta	94,103	TNF-alpha	IL-1 beta	7124	3553	Gene	Gene	IL-10|amod|START_ENTITY IL-10|amod|END_ENTITY	Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha , IL-1_beta IL-10 by human leucocytes .
8023931	0	TNF-alpha	52,61	IL-1_receptor_antagonist	10,34	TNF-alpha	IL-1 receptor antagonist	24835(Tax:10116)	60582(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of IL-1_receptor_antagonist and antiserum to TNF-alpha on LPS-induced plasma ACTH and corticosterone rise in rats .
8435447	0	TNF-alpha	114,123	IL-1_receptor_antagonist	17,41	TNF-alpha	IL-1 receptor antagonist	7124	3557	Gene	Gene	increased|nmod|START_ENTITY increased|nsubj|synthesis synthesis|nmod|END_ENTITY	The synthesis of IL-1_receptor_antagonist -LRB- IL-1ra -RRB- by synovial fibroblasts is markedly increased by the cytokines TNF-alpha and IL-1 .
8809146	0	TNF-alpha	167,176	IL-1_receptor_antagonist	62,86	TNF-alpha	IL-1 receptor antagonist	7124	3557	Gene	Gene	factor-alpha|appos|START_ENTITY down-regulation|nmod|factor-alpha properties|dep|down-regulation properties|dep|induction induction|nmod|END_ENTITY	Anti-inflammatory properties of human serum IgA : induction of IL-1_receptor_antagonist and Fc_alpha_R -LRB- CD89 -RRB- - mediated down-regulation of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and IL-6 in human monocytes .
11137138	0	TNF-alpha	84,93	IL-1alpha	73,82	TNF-alpha	IL-1alpha	7124	3552	Gene	Gene	level|nsubj|START_ENTITY level|nmod|effect effect|nmod|phospholipase_A2 phospholipase_A2|nmod|END_ENTITY	In vivo effect of snake phospholipase_A2 -LRB- crotoxin + cardiotoxin -RRB- on serum IL-1alpha , TNF-alpha and IL-1ra level in humans .
14655147	0	TNF-alpha	62,71	IL-1alpha	32,41	TNF-alpha	IL-1alpha	7124	3552	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Tissue expression of cytokines -LRB- IL-1alpha , IL-2 , IL-6 , IL-12 , TNF-alpha -RRB- in B-cell_lymphomas in children .
8907203	0	TNF-alpha	17,26	IL-1alpha	28,37	TNF-alpha	IL-1alpha	7124	3552	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Cytokines -LRB- IL-6 , TNF-alpha , IL-1alpha -RRB- and soluble interleukin-2 receptor as serum tumor markers in multiple_myeloma .
10469275	0	TNF-alpha	99,108	IL-1beta	89,97	TNF-alpha	IL-1beta	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	PTHrP|appos|START_ENTITY PTHrP|compound|END_ENTITY	A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta , TNF-alpha , PTH , PTHrP , and 1 , _ 25 -LRB- OH -RRB- 2D3 .
10525318	0	TNF-alpha	35,44	IL-1beta	46,54	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Induced heteroduplex genotyping of TNF-alpha , IL-1beta , IL-6 and IL-10 polymorphisms associated with transcriptional regulation .
11956032	0	TNF-alpha	76,85	IL-1beta	33,41	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of interleukin-1beta -LRB- IL-1beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- production by neuronal precursor cells .
12115655	0	TNF-alpha	131,140	IL-1beta	64,72	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	release|amod|START_ENTITY inhibited|nsubjpass|release attenuates|advcl|inhibited attenuates|dobj|release release|compound|END_ENTITY	Granulocyte_colony-stimulating_factor attenuates LPS-stimulated IL-1beta release via suppressed processing of proIL-1beta , whereas TNF-alpha release is inhibited on the level of proTNF-alpha formation .
12392281	0	TNF-alpha	43,52	IL-1beta	0,8	TNF-alpha	IL-1beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	IL-1beta and IL-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma .
12631070	0	TNF-alpha	10,19	IL-1beta	0,8	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	expression|nsubj|START_ENTITY expression|advmod|END_ENTITY	IL-1beta , TNF-alpha , TGF-beta , and bFGF expression in bone biopsies before and after parathyroidectomy .
12962834	0	TNF-alpha	43,52	IL-1beta	54,62	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Effect of proinflammatory cytokines -LRB- IL-6 , TNF-alpha , IL-1beta -RRB- on hemodynamic performance during orthotopic liver transplantation .
15047987	0	TNF-alpha	79,88	IL-1beta	69,77	TNF-alpha	IL-1beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	release|amod|START_ENTITY release|dep|END_ENTITY	Immunophilin ligands decrease release of pro-inflammatory cytokines -LRB- IL-1beta , TNF-alpha and IL-2 in rat astrocyte cultures exposed to simulated ischemia in vitro .
15050606	0	TNF-alpha	67,76	IL-1beta	20,28	TNF-alpha	IL-1beta	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY induces|dobj|expression induces|nsubj|Interleukin-1_beta Interleukin-1_beta|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1beta -RRB- induces tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation .
16489252	0	TNF-alpha	49,58	IL-1beta	21,29	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
17786499	0	TNF-alpha	81,90	IL-1beta	71,79	TNF-alpha	IL-1beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	bFGF|appos|START_ENTITY bFGF|compound|END_ENTITY	Effects of low-level He-Ne laser irradiation on the gene expression of IL-1beta , TNF-alpha , IFN-gamma , TGF-beta , bFGF , and PDGF in rat 's gingiva .
18668392	0	TNF-alpha	48,57	IL-1beta	23,31	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	enhancing|dobj|START_ENTITY suppressed|advcl|enhancing suppressed|dobj|END_ENTITY	Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10 , when cells in whole blood were stimulated with lipopolysaccharide .
18783962	4	TNF-alpha	778,787	IL-1beta	789,797	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	IL-6|amod|START_ENTITY IL-6|dep|END_ENTITY	TNF-alpha , IL-1beta , IL-6 , and IL-10 levels were all elevated after the initiation of cardiopulmonary bypass .
20202693	0	TNF-alpha	0,9	IL-1beta	11,19	TNF-alpha	IL-1beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	IL-6|amod|START_ENTITY IL-6|amod|END_ENTITY	TNF-alpha , IL-1beta , IL-6 , and cinc-1 levels in rat brain after meningitis induced by Streptococcus_pneumoniae .
25291965	0	TNF-alpha	33,42	IL-1beta	17,25	TNF-alpha	IL-1beta	7124	3553	Gene	Gene	_|amod|START_ENTITY and/or|iobj|_ and/or|nsubj|END_ENTITY	Pro-inflammatory IL-1beta and/or TNF-alpha up-regulate matrix_metalloproteases-1_and _ -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis : in situ hybridization studies on a single cell level .
10390079	0	TNF-alpha	17,26	IL-2	28,32	TNF-alpha	IL-2	7124	3558	Gene	Gene	IFNs|dep|START_ENTITY IFNs|dep|END_ENTITY	Cytokines -LRB- IFNs , TNF-alpha , IL-2 and IL-12 -RRB- and animal models of cancer .
11427636	0	TNF-alpha	52,61	IL-2	84,88	TNF-alpha	IL-2	7124	3558	Gene	Gene	system|amod|START_ENTITY activation|nmod|system activation|dep|system system|compound|END_ENTITY	Quantitative flow cytometry shows activation of the TNF-alpha system but not of the IL-2 system at the single cell level in renal replacement therapy .
1337985	0	TNF-alpha	93,102	IL-2	18,22	TNF-alpha	IL-2	7124	3558	Gene	Gene	lymphotoxin|compound|START_ENTITY mediated|nmod|lymphotoxin mediated|nsubjpass|synergy synergy|nmod|END_ENTITY	IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-alpha and beta -LRB- lymphotoxin -RRB- .
14655147	0	TNF-alpha	62,71	IL-2	43,47	TNF-alpha	IL-2	7124	3558	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Tissue expression of cytokines -LRB- IL-1alpha , IL-2 , IL-6 , IL-12 , TNF-alpha -RRB- in B-cell_lymphomas in children .
15806975	0	TNF-alpha	109,118	IL-2	135,139	TNF-alpha	IL-2	7124	3558	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY interferon-gamma|appos|tumor_necrosis_factor-alpha efficacy|appos|interferon-gamma interleukin-2|nsubj|efficacy interleukin-2|dobj|levels levels|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
16489252	0	TNF-alpha	49,58	IL-2	31,35	TNF-alpha	IL-2	7124	3558	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
2065356	0	TNF-alpha	20,29	IL-2	0,4	TNF-alpha	IL-2	7124	3558	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|dose dose|compound|END_ENTITY	IL-2 dose regulates TNF-alpha mRNA transcription and protein secretion in human peripheral blood lymphocytes .
7544321	0	TNF-alpha	109,118	IL-2	56,60	TNF-alpha	IL-2	21926(Tax:10090)	16183(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY promote|dobj|synthesis synergizes|xcomp|promote synergizes|nmod|END_ENTITY	Tumor-derived factor synergizes with IFN-gamma and LPS , IL-2 or TNF-alpha to promote macrophage synthesis of TNF-alpha and TNF_receptors for autocrine induction of nitric_oxide synthase and enhanced nitric_oxide-mediated tumor_cytotoxicity .
8930418	0	TNF-alpha	9,18	IL-2	20,24	TNF-alpha	IL-2	7124	3558	Gene	Gene	markers|nmod|START_ENTITY markers|nsubj|END_ENTITY	In vitro TNF-alpha , IL-2 and IFN-gamma production as markers of relapses in multiple_sclerosis .
9776110	0	TNF-alpha	27,36	IL-2	75,79	TNF-alpha	IL-2	7124	3558	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
20468050	0	TNF-alpha	28,37	IL-27	0,5	TNF-alpha	IL-27	7124	246778	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IL-27 inhibits OSM-mediated TNF-alpha and iNOS gene expression in microglia .
10227996	0	TNF-alpha	32,41	IL-4	0,4	TNF-alpha	IL-4	7124	3565	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IL-4 inhibits the production of TNF-alpha and IL-12 by STAT6-dependent and - independent mechanisms .
10233853	0	TNF-alpha	96,105	IL-4	133,137	TNF-alpha	IL-4	7124	3565	Gene	Gene	achieved|nmod|START_ENTITY achieved|nmod|END_ENTITY	Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability .
10460779	0	TNF-alpha	47,56	IL-4	0,4	TNF-alpha	IL-4	7124	3565	Gene	Gene	induced|nmod|START_ENTITY production|acl|induced regulates|dobj|production regulates|nsubj|END_ENTITY	IL-4 regulates chemokine production induced by TNF-alpha in keratocytes and corneal epithelial cells .
12441140	0	TNF-alpha	152,161	IL-4	0,4	TNF-alpha	IL-4	7124	3565	Gene	Gene	CXCL10|nmod|START_ENTITY modulates|ccomp|CXCL10 modulates|nsubj|END_ENTITY	IL-4 , but not IL-13 , modulates TARC -LRB- thymus_and_activation-regulated_chemokine -RRB- / CCL17 and IP-10 -LRB- interferon-induced_protein_of_10kDA -RRB- / CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line .
12569762	0	TNF-alpha	40,49	IL-4	14,18	TNF-alpha	IL-4	7124	3565	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Influence of IL-4 on the expression of TNF-alpha and IL-1_alpha mRNA by PBMCs from patients with subfulminant viral_hepatitis before and after treatment -RSB- .
12670721	0	TNF-alpha	32,41	IL-4	5,9	TNF-alpha	IL-4	7124	3565	Gene	Gene	enhanced|nsubj|START_ENTITY inhibit|ccomp|enhanced inhibit|nsubj|END_ENTITY	Both IL-4 and IL-13 inhibit the TNF-alpha and IFN-gamma enhanced MDC production in a human keratinocyte cell line , HaCaT cells .
12954239	0	TNF-alpha	49,58	IL-4	94,98	TNF-alpha	IL-4	280943(Tax:9913)	280824(Tax:9913)	Gene	Gene	IFN-gamma|compound|START_ENTITY IL-1_alpha|dep|IFN-gamma pro-inflammatory|appos|IL-1_alpha pro-inflammatory|appos|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
14971043	0	TNF-alpha	109,118	IL-4	58,62	TNF-alpha	IL-4	21926(Tax:10090)	16189(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY changes|nmod|effects Pulmonary_tuberculosis|dep|changes Pulmonary_tuberculosis|nmod|mice mice|nmod|genes genes|compound|END_ENTITY	Pulmonary_tuberculosis in BALB/c mice with non-functional IL-4 genes : changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis .
16513426	0	TNF-alpha	41,50	IL-4	52,56	TNF-alpha	IL-4	7124	3565	Gene	Gene	IL-5|appos|START_ENTITY IL-5|appos|END_ENTITY	Evaluation of cytokines -LRB- MIG , IFN-gamma , TNF-alpha , IL-4 , IL-5 , and IL-10 -RRB- during the different evolutive phases of chagasic esophagopathy .
16810557	0	TNF-alpha	18,27	IL-4	0,4	TNF-alpha	IL-4	7124	3565	Gene	Gene	proliferation|amod|START_ENTITY inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	IL-4 inhibits the TNF-alpha induced proliferation of renal_cell_carcinoma -LRB- RCC -RRB- and cooperates with TNF-alpha to induce apoptotic and cytokine responses by RCC : implications for antitumor immune responses .
17617590	0	TNF-alpha	35,44	IL-4	0,4	TNF-alpha	IL-4	7124	3565	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	IL-4 and IL-13 negatively regulate TNF-alpha - and IFN-gamma-induced beta-defensin expression through STAT-6 , suppressor_of_cytokine_signaling _ -LRB- SOCS -RRB- -1 , and SOCS-3 .
19521071	0	TNF-alpha	52,61	IL-4	64,68	TNF-alpha	IL-4	7124	3565	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Global gene analysis of Erigeron canadensis-treated TNF-alpha - , IL-4 - and IL-1beta-stimulated A549 human epithelial cells .
2113430	0	TNF-alpha	0,9	IL-4	32,36	TNF-alpha	IL-4	7124	3565	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	TNF-alpha and IFN-gamma reverse IL-4 inhibition of lymphokine-activated killer cell function .
2118480	0	TNF-alpha	69,78	IL-4	46,50	TNF-alpha	IL-4	21926(Tax:10090)	16189(Tax:10090)	Gene	Gene	enhancement|nmod|START_ENTITY enhancement|dep|Priming Priming|nmod|END_ENTITY	Priming the macrophage respiratory burst with IL-4 : enhancement with TNF-alpha but inhibition by IFN-gamma .
8742066	0	TNF-alpha	104,113	IL-4	0,4	TNF-alpha	IL-4	7124	3565	Gene	Gene	release|compound|START_ENTITY changes|nmod|release have|nmod|changes have|nsubj|END_ENTITY	IL-4 , IL-10 and IFN-gamma have distinct , but interacting , effects on differentiation-induced changes in TNF-alpha and TNF receptor release by cultured human monocytes .
9486409	0	TNF-alpha	83,92	IL-4	156,160	TNF-alpha	IL-4	21926(Tax:10090)	16189(Tax:10090)	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|amod|transgenic_mice transgenic_mice|nmod|treatment treatment|nmod|cells cells|acl|engineered engineered|xcomp|secrete secrete|dobj|END_ENTITY	Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- - transgenic_mice by treatment with cells engineered to secrete IL-4 , IL-10 or IL-13 .
9776110	0	TNF-alpha	27,36	IL-4	81,85	TNF-alpha	IL-4	7124	3565	Gene	Gene	pro-inflammatory|appos|START_ENTITY pro-inflammatory|appos|IL-2 IL-2|dep|END_ENTITY	Study of pro-inflammatory -LRB- TNF-alpha , IL-1alpha , IL-6 -RRB- and T-cell-derived -LRB- IL-2 , IL-4 -RRB- cytokines in plasma and synovial fluid of patients with juvenile_chronic_arthritis : correlations with clinical and laboratory parameters .
10462929	0	TNF-alpha	53,62	IL-6	47,51	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-1_beta|dep|START_ENTITY IL-1_beta|dep|END_ENTITY	Study on proinflammatory cytokines -LRB- IL-1_beta , IL-6 , TNF-alpha -RRB- and IL-2 in patients with acute hepatitis_B .
10528667	0	TNF-alpha	63,72	IL-6	57,61	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-1beta|appos|START_ENTITY IL-1beta|appos|END_ENTITY	Whole blood production of monocytic cytokines -LRB- IL-1beta , IL-6 , TNF-alpha , sIL-6R , IL-1Ra -RRB- in haemodialysed patients .
10552211	0	TNF-alpha	111,120	IL-6	47,51	TNF-alpha	IL-6	7124	3569	Gene	Gene	secrete|nmod|START_ENTITY secrete|dobj|amounts amounts|nmod|END_ENTITY	Psoriatic fibroblasts secrete lower amounts of IL-6 than healthy fibroblasts before and after stimulation with TNF-alpha .
10601562	0	TNF-alpha	114,123	IL-6	56,60	TNF-alpha	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY cells|nmod|independent upregulate|nmod|cells upregulate|dobj|production production|compound|END_ENTITY	Elevated GM-CSF levels in tumor bearing mice upregulate IL-6 production by B cells via a mechanism independent of TNF-alpha .
10620700	0	TNF-alpha	86,95	IL-6	52,56	TNF-alpha	IL-6	7124	3569	Gene	Gene	fibroblasts|amod|START_ENTITY production|nmod|fibroblasts production|amod|END_ENTITY	The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha - or IL-1beta-stimulated rheumatoid synovial fibroblasts .
10623436	0	TNF-alpha	59,68	IL-6	70,74	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-1beta|dep|START_ENTITY IL-1beta|dep|END_ENTITY	Direct influences of pro-inflammatory cytokines -LRB- IL-1beta , TNF-alpha , IL-6 -RRB- on the proliferation and cell-surface_antigen expression of cancer cells .
10697395	0	TNF-alpha	34,43	IL-6	64,68	TNF-alpha	IL-6	7124	3569	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	-LSB- Levels of tumor_necrosis_factor -LRB- TNF-alpha -RRB- and interleukin_6 -LRB- IL-6 -RRB- in serum of patients with acute myocardial_infarction -RSB- .
10951379	0	TNF-alpha	42,51	IL-6	73,77	TNF-alpha	IL-6	7124	3569	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Combined effect of titanium particles and TNF-alpha on the production of IL-6 by osteoblast-like cells .
10978634	0	TNF-alpha	68,77	IL-6	62,66	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-1beta|dep|START_ENTITY IL-1beta|dep|END_ENTITY	Quantitative analysis of proinflammatory cytokines -LRB- IL-1beta , IL-6 , TNF-alpha -RRB- in human skin_wounds .
11266093	0	TNF-alpha	0,9	IL-6	11,15	TNF-alpha	IL-6	7124	3569	Gene	Gene	serum|advmod|START_ENTITY serum|nsubj|END_ENTITY	TNF-alpha , IL-6 and their soluble receptor serum levels and secretion by neutrophils in cancer patients .
11370171	0	TNF-alpha	19,28	IL-6	79,83	TNF-alpha	IL-6	7124	3569	Gene	Gene	secretion|nmod|START_ENTITY correlate|nsubj|secretion correlate|nmod|END_ENTITY	Local secretion of TNF-alpha from the liver does not correlate with endotoxin , IL-6 , or organ function in the early phase after orthotopic liver transplantation .
11544427	0	TNF-alpha	0,9	IL-6	11,15	TNF-alpha	IL-6	7124	3569	Gene	Gene	IFN-gamma|compound|START_ENTITY IFN-gamma|appos|END_ENTITY	TNF-alpha , IL-6 , IFN-gamma , and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R : effects on renal allograft outcome .
11743653	0	TNF-alpha	29,38	IL-6	46,50	TNF-alpha	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	roles|appos|START_ENTITY roles|appos|END_ENTITY	Discrete roles of cytokines , TNF-alpha , IL-1 , IL-6 in tumor promotion and cell transformation .
11819289	0	TNF-alpha	23,32	IL-6	33,37	TNF-alpha	IL-6	7124	3569	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	In vitro production of TNF-alpha , IL-6 and sIL-2R in Chinese patients with ulcerative_colitis .
12370360	0	TNF-alpha	85,94	IL-6	28,32	TNF-alpha	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha .
12445803	0	TNF-alpha	78,87	IL-6	104,108	TNF-alpha	IL-6	7124	3569	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|amod|interleukin-6 interleukin-6|dep|END_ENTITY	Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- interleukin-6 -LRB- IL-6 -RRB- and soluble interleukin-6_receptor -LRB- sIL-6R gp80 -RRB- in multiple_sclerosis patients .
12477628	0	TNF-alpha	91,100	IL-6	85,89	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-1beta|dep|START_ENTITY IL-1beta|dep|END_ENTITY	Time-dependent immunohistochemical detection of proinflammatory cytokines -LRB- IL-1beta , IL-6 , TNF-alpha -RRB- in human skin_wounds .
12817006	0	TNF-alpha	0,9	IL-6	157,161	TNF-alpha	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|phosphatase phosphatase|nmod|subunit subunit|nmod|complex complex|compound|END_ENTITY	TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex .
12954239	0	TNF-alpha	49,58	IL-6	43,47	TNF-alpha	IL-6	280943(Tax:9913)	517016(Tax:9913)	Gene	Gene	IFN-gamma|compound|START_ENTITY IL-1_alpha|dep|IFN-gamma IL-1_alpha|dep|END_ENTITY	Influence of pro-inflammatory -LRB- IL-1_alpha , IL-6 , TNF-alpha , IFN-gamma -RRB- and anti-inflammatory -LRB- IL-4 -RRB- cytokines on chondrocyte function .
15298427	0	TNF-alpha	102,111	IL-6	113,117	TNF-alpha	IL-6	7124	3569	Gene	Gene	effects|nmod|START_ENTITY reaction|dep|effects reaction|amod|IL-10 IL-10|amod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
15383953	0	TNF-alpha	41,50	IL-6	62,66	TNF-alpha	IL-6	7124	3569	Gene	Gene	START_ENTITY|dep|IFN-gamma IFN-gamma|compound|END_ENTITY	-LSB- Evaluation of proinflammatory cytokine -LRB- TNF-alpha , IL-1beta , IL-6 , IFN-gamma -RRB- concentrations in serum and cerebrospinal fluid of patients with neuroborreliosis -RSB- .
15622443	0	TNF-alpha	0,9	IL-6	29,33	TNF-alpha	IL-6	7124	3569	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
15663746	0	TNF-alpha	0,9	IL-6	23,27	TNF-alpha	IL-6	7124	3569	Gene	Gene	START_ENTITY|dep|TNF-beta TNF-beta|parataxis|END_ENTITY	TNF-alpha - , TNF-beta - , IL-6 - , and IL-10-promoter polymorphisms in patients with chronic obstructive pulmonary_disease .
15665514	0	TNF-alpha	69,78	IL-6	152,156	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha - and LPS-induced NF-kappaB-dependent transcription and TNF-alpha-induced IL-6 secretion in ventricular myocytes .
15848524	0	TNF-alpha	46,55	IL-6	57,61	TNF-alpha	IL-6	7124	3569	Gene	Gene	START_ENTITY|dep|MCP-1 MCP-1|compound|END_ENTITY	Effect of cytokines and chemokines -LRB- TGF-beta , TNF-alpha , IL-6 , IL-10 , MCP-1 , RANTES -RRB- gene polymorphisms in kidney recipients on posttransplantation outcome : influence of donor-recipient match .
16258194	0	TNF-alpha	16,25	IL-6	38,42	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-17|compound|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
1636726	0	TNF-alpha	14,23	IL-6	0,4	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	increase|amod|START_ENTITY enhances|dobj|increase enhances|nsubj|END_ENTITY	IL-6 enhances TNF-alpha - and IL-1-induced increase of Mn_superoxide dismutase mRNA and O2 tolerance .
16734992	0	TNF-alpha	37,46	IL-6	48,52	TNF-alpha	IL-6	7124	3569	Gene	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	The effect of periodontal therapy on TNF-alpha , IL-6 and metabolic control in type 2 diabetics .
16857895	0	TNF-alpha	65,74	IL-6	86,90	TNF-alpha	IL-6	7124	3569	Gene	Gene	effects|nmod|START_ENTITY prevents|dobj|effects prevents|nmod|secretion secretion|compound|END_ENTITY	High dexamethasone concentration prevents stimulatory effects of TNF-alpha and LPS on IL-6 secretion from the precursors of human muscle regeneration .
16864705	0	TNF-alpha	78,87	IL-6	73,77	TNF-alpha	IL-6	7124	3569	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Innate immunity of the human newborn is polarized toward a high ratio of IL-6 / TNF-alpha production in vitro and in vivo .
17483704	0	TNF-alpha	0,9	IL-6	21,25	TNF-alpha	IL-6	7124	3569	Gene	Gene	PECAM-1|compound|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
17725274	0	TNF-alpha	109,118	IL-6	136,140	TNF-alpha	IL-6	7124	3569	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|tumor_necrosis_factor vascular_endothelial_growth_factor|appos|interleukin_6 interleukin_6|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
17901573	0	TNF-alpha	107,116	IL-6	129,133	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	Influence of enalapril , quinapril and losartan on lipopolysaccharide -LRB- LPS -RRB- - induced serum concentrations of TNF-alpha , IL-1_beta , IL-6 in spontaneously hypertensive rats -LRB- SHR -RRB- .
18176176	0	TNF-alpha	51,60	IL-6	15,19	TNF-alpha	IL-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY Interleukin-6|appos|levels Interleukin-6|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
18976114	0	TNF-alpha	138,147	IL-6	149,153	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	glucose|compound|START_ENTITY glucose|appos|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
18976114	0	TNF-alpha	32,41	IL-6	43,47	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	IL-8|compound|START_ENTITY IL-8|appos|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
19099662	0	TNF-alpha	57,66	IL-6	68,72	TNF-alpha	IL-6	397086(Tax:9823)	100628202	Gene	Gene	START_ENTITY|appos|expressions expressions|compound|END_ENTITY	-LSB- Effect of free hemoglobin on hemorrhagic_shock in pigs : TNF-alpha , IL-6 expressions in serum and rates of MODS after the blood transfusion -RSB- .
19437229	0	TNF-alpha	41,50	IL-6	35,39	TNF-alpha	IL-6	7124	3569	Gene	Gene	homocysteine|appos|START_ENTITY homocysteine|appos|END_ENTITY	Association of maternal serum CRP , IL-6 , TNF-alpha , homocysteine , folic_acid and vitamin_B12 levels with the severity of preeclampsia and fetal birth weight .
20055787	0	TNF-alpha	26,35	IL-6	14,18	TNF-alpha	IL-6	7124	3569	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|compound|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
20103767	0	TNF-alpha	0,9	IL-6	11,15	TNF-alpha	IL-6	7124	3569	Gene	Gene	inhibited|advmod|START_ENTITY inhibited|nsubjpass|expression expression|amod|END_ENTITY	TNF-alpha , IL-6 , and IL-1 expression is inhibited by GAS6 in monocytes/macrophages .
20617559	0	TNF-alpha	0,9	IL-6	28,32	TNF-alpha	IL-6	7124	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TNF-alpha similarly induces IL-6 and MCP-1 in fibroblasts from colorectal liver metastases and normal liver fibroblasts .
21173731	0	TNF-alpha	6,15	IL-6	0,4	TNF-alpha	IL-6	7124	3569	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	IL-6 , TNF-alpha , IL-1-beta arterial wall expression is independent of serum concentration in patients sustaining primary or secondary open vascular reconstructions .
21591983	0	TNF-alpha	17,26	IL-6	47,51	TNF-alpha	IL-6	7124	3569	Gene	Gene	GPIA|compound|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
23241117	0	TNF-alpha	27,36	IL-6	38,42	TNF-alpha	IL-6	7124	3569	Gene	Gene	RANKL|compound|START_ENTITY RANKL|appos|END_ENTITY	Changes in serum levels of TNF-alpha , IL-6 , OPG , RANKL and their correlation with radiographic and clinical assessment in fragility_fractures and high energy fractures .
23940968	0	TNF-alpha	28,37	IL-6	39,43	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	exercises|nmod|START_ENTITY effect|nmod|exercises -LSB-|dobj|effect -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The effect of exercises on TNF-alpha , IL-6 and adiponectin in different fat diet rats -RSB- .
25530051	0	TNF-alpha	59,68	IL-6	53,57	TNF-alpha	IL-6	7124	3569	Gene	Gene	hs-CRP|appos|START_ENTITY hs-CRP|appos|END_ENTITY	Evaluation of Plasma Concentrations of Homocysteine , IL-6 , TNF-alpha , hs-CRP , and Total Antioxidant Capacity in Patients with End-Stage_Renal_Failure .
25634659	0	TNF-alpha	15,24	IL-6	26,30	TNF-alpha	IL-6	7124	3569	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Association of TNF-alpha , IL-6 and IL-1beta gene polymorphisms with polycystic_ovary_syndrome : a meta-analysis .
25634659	0	TNF-alpha	15,24	IL-6	26,30	TNF-alpha	IL-6	7124	3569	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Association of TNF-alpha , IL-6 and IL-1beta gene polymorphisms with polycystic_ovary_syndrome : a meta-analysis .
7531001	0	TNF-alpha	149,158	IL-6	143,147	TNF-alpha	IL-6	7124	3569	Gene	Gene	CD14|appos|START_ENTITY CD14|compound|END_ENTITY	Infusion of large quantities of autologous blood monocyte-derived macrophages in two cancer patients did not induce increased concentration of IL-6 , TNF-alpha , soluble CD14 and nitrate in blood plasma .
7558123	0	TNF-alpha	22,31	IL-6	16,20	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Cytokine -LRB- IL-8 , IL-6 , TNF-alpha -RRB- and soluble TNF receptor-I release from human peripheral blood mononuclear cells after respiratory_syncytial_virus_infection .
7590883	0	TNF-alpha	35,44	IL-6	75,79	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	relationship|nmod|START_ENTITY relationship|nmod|secretion secretion|compound|END_ENTITY	A synergistic relationship between TNF-alpha , IL-1_beta , and TGF-beta_1 on IL-6 secretion by the IEC-6 intestinal epithelial cell line .
7921752	0	TNF-alpha	23,32	IL-6	120,124	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-6|dep|START_ENTITY cytokines|appos|IL-6 cytokines|dep|correlation correlation|nmod|END_ENTITY	Serum cytokines -LRB- IL-6 , TNF-alpha , IL-1_beta and IFN-gamma -RRB- in ankylosing_spondylitis : a close correlation between serum IL-6 and disease activity and severity .
7927487	0	TNF-alpha	82,91	IL-6	76,80	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-8|dep|START_ENTITY IL-8|dep|END_ENTITY	Effect of respiratory syncytial virus-antibody complexes on cytokine -LRB- IL-8 , IL-6 , TNF-alpha -RRB- release and respiratory burst in human granulocytes .
8710173	0	TNF-alpha	19,28	IL-6	30,34	TNF-alpha	IL-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Early increases in TNF-alpha , IL-6 and IL-1_beta levels following transient cerebral_ischemia in gerbil brain .
8928089	0	TNF-alpha	0,9	IL-6	21,25	TNF-alpha	IL-6	7124	3569	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|upregulation upregulation|compound|END_ENTITY	TNF-alpha suppresses IL-6 upregulation of protein S in HepG-2 hepatoma cells .
9191887	0	TNF-alpha	169,178	IL-6	149,153	TNF-alpha	IL-6	7124	3569	Gene	Gene	TNF-beta|appos|START_ENTITY TNF-beta|appos|END_ENTITY	Cytokine dichotomy in peripheral nervous system influences the outcome of experimental_allergic_neuritis : dynamics of mRNA expression for IL-1_beta , IL-6 , IL-10 , IL-12 , TNF-alpha , TNF-beta , and cytolysin .
9209124	0	TNF-alpha	73,82	IL-6	34,38	TNF-alpha	IL-6	7124	3569	Gene	Gene	interleukin-6|appos|START_ENTITY interleukin-6|appos|END_ENTITY	-LSB- The evaluation of interleukin-6 -LRB- IL-6 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- level in peripheral blood of patients with chronic_lower_respiratory_tract_infection -RSB- .
9594206	0	TNF-alpha	24,33	IL-6	35,39	TNF-alpha	IL-6	7124	3569	Gene	Gene	IL-1_beta|appos|START_ENTITY study|nmod|IL-1_beta END_ENTITY|nsubj|study	The study of IL-1_beta , TNF-alpha , IL-6 gene expression and plasma levels on hemodialysis before and after dialyzer reuse .
9718198	0	TNF-alpha	0,9	IL-6	34,38	TNF-alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|genes genes|compound|END_ENTITY	TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2 .8 cells .
11332087	0	TNF-alpha	12,21	IL-8	25,29	TNF-alpha	IL-8	7124	3576	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of TNF-alpha on IL-8 mRNA expression in endothelial cells -RSB- .
11597930	0	TNF-alpha	84,93	IL-8	27,31	TNF-alpha	IL-8	7124	3576	Gene	Gene	phospholipids|amod|START_ENTITY regulated|nmod|phospholipids regulated|nsubjpass|transcription transcription|nmod|END_ENTITY	Increased transcription of IL-8 in endothelial cells is differentially regulated by TNF-alpha and oxidized phospholipids .
12204776	0	TNF-alpha	56,65	IL-8	113,117	TNF-alpha	IL-8	7124	3576	Gene	Gene	START_ENTITY|acl|stimulated stimulated|advcl|blocking blocking|dobj|secretion secretion|amod|END_ENTITY	17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion , but not its transcription .
15081568	0	TNF-alpha	14,23	IL-8	68,72	TNF-alpha	IL-8	7124	3576	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of TNF-alpha , PMA , and LPS on plasma and cell-associated IL-8 in human leukocytes .
15162444	0	TNF-alpha	23,32	IL-8	91,95	TNF-alpha	IL-8	7124	3576	Gene	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|release release|compound|END_ENTITY	The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa_B-dependent IL-8 release .
15217317	0	TNF-alpha	97,106	IL-8	63,67	TNF-alpha	IL-8	7124	3576	Gene	Gene	responses|amod|START_ENTITY unlinked|nmod|responses response|acl:relcl|unlinked response|compound|END_ENTITY	Leprosy patients with lepromatous_disease have an up-regulated IL-8 response that is unlinked to TNF-alpha responses .
15225374	0	TNF-alpha	21,30	IL-8	60,64	TNF-alpha	IL-8	7124	3576	Gene	Gene	production|amod|START_ENTITY inhibition|nmod|production inhibition|nmod|expression expression|amod|END_ENTITY	Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ_67657 , a p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- inhibitor .
15273081	0	TNF-alpha	39,48	IL-8	12,16	TNF-alpha	IL-8	7124	3576	Gene	Gene	Exaggerated|nmod|START_ENTITY Exaggerated|dobj|responses responses|amod|END_ENTITY	Exaggerated IL-8 and IL-6 responses to TNF-alpha by parainfluenza_virus_type_4-infected NCI-H292 cells .
15298427	0	TNF-alpha	102,111	IL-8	119,123	TNF-alpha	IL-8	7124	3576	Gene	Gene	effects|nmod|START_ENTITY reaction|dep|effects reaction|amod|IL-10 IL-10|amod|END_ENTITY	Methylprednisolone prevents inflammatory reaction occurring during cardiopulmonary bypass : effects on TNF-alpha , IL-6 , IL-8 , IL-10 .
16258194	0	TNF-alpha	16,25	IL-8	44,48	TNF-alpha	IL-8	7124	3576	Gene	Gene	IL-17|compound|START_ENTITY IL-17|appos|END_ENTITY	Serum levels of TNF-alpha , IFN-gamma , IL-6 , IL-8 , IL-12 , IL-17 , and IL-18 in patients with active psoriasis and correlation with disease severity .
16489252	0	TNF-alpha	49,58	IL-8	43,47	TNF-alpha	IL-8	7124	3576	Gene	Gene	IL-6|dep|START_ENTITY IL-6|dep|END_ENTITY	Levels of cytokines -LRB- IL-1beta , IL-2 , IL-6 , IL-8 , TNF-alpha -RRB- and trace elements -LRB- Zn , Cu -RRB- in breast milk from mothers of preterm and term infants .
16949835	0	TNF-alpha	55,64	IL-8	36,40	TNF-alpha	IL-8	7124	3576	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha - and dexamethasone-stimulated human periodontal ligament cells .
17306937	0	TNF-alpha	43,52	IL-8	66,70	TNF-alpha	IL-8	7124	3576	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	The role of sphingosine_1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells .
17546909	0	TNF-alpha	49,58	IL-8	43,47	TNF-alpha	IL-8	7124	3576	Gene	Gene	IL-2R|dep|START_ENTITY IL-2R|dep|END_ENTITY	Platelet storage time and cytokine -LRB- IL-2R , IL-8 , TNF-alpha -RRB- levels .
19874800	0	TNF-alpha	97,106	IL-8	0,4	TNF-alpha	IL-8	7124	3576	Gene	Gene	combined|nmod|START_ENTITY enhanced|ccomp|combined enhanced|nsubj|production production|compound|END_ENTITY	IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-alpha .
20055787	0	TNF-alpha	26,35	IL-8	20,24	TNF-alpha	IL-8	7124	3576	Gene	Gene	HSP-60|appos|START_ENTITY HSP-60|appos|END_ENTITY	Expression of IL-6 , IL-8 , TNF-alpha , IL-10 , HSP-60 , anti-HSP-60 antibodies , and anti-sperm antibodies , in semen of men with leukocytes and/or bacteria .
22561123	0	TNF-alpha	72,81	IL-8	104,108	TNF-alpha	IL-8	7124	3576	Gene	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells .
24994458	0	TNF-alpha	29,38	IL-8	23,27	TNF-alpha	IL-8	7124	3576	Gene	Gene	START_ENTITY|nsubj|IL-6 IL-6|appos|END_ENTITY	Increased plasma IL-6 , IL-8 , TNF-alpha , and G-CSF in Japanese narcolepsy .
15275867	0	TNF-alpha	67,76	IRAK-M	41,47	TNF-alpha	IRAK-M	7124	11213	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Nitric_oxide activates the expression of IRAK-M via the release of TNF-alpha in human monocytes .
12411051	0	TNF-alpha	52,61	IkappaB-alpha	27,40	TNF-alpha	IkappaB-alpha	7124	4792	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Study on the expression of IkappaB-alpha protein in TNF-alpha induced apoptosis of U937 cells .
11883273	0	TNF-alpha	56,65	Il-6	50,54	TNF-alpha	Il-6	7124	3569	Gene	Gene	Il-1_alpha|dep|START_ENTITY Il-1_alpha|dep|END_ENTITY	-LSB- Levels of proinflammatory cytokines -LRB- Il-1_alpha , Il-6 , TNF-alpha -RRB- in the semen plasma of male partners of infertile couples -RSB- .
12923954	0	TNF-alpha	47,56	Il-8	27,31	TNF-alpha	Il-8	7124	3576	Gene	Gene	Il-10|dep|START_ENTITY Il-10|dep|END_ENTITY	-LSB- Selected cytokines -LRB- Il-6 , Il-8 , Il-10 , MCP-1 , TNF-alpha -RRB- in children and adolescents with atherosclerosis risk factors : obesity , hypertension , diabetes -RSB- .
18023359	0	TNF-alpha	50,59	Interleukin-10	0,14	TNF-alpha	Interleukin-10	7124	3586	Gene	Gene	effects|nmod|START_ENTITY modulates|dobj|effects modulates|nsubj|END_ENTITY	Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro .
1639861	0	TNF-alpha	32,41	Interleukin-1_beta	0,18	TNF-alpha	Interleukin-1 beta	7124	3553	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Interleukin-1_beta induction of TNF-alpha gene expression : involvement of protein_kinase_C .
9570721	0	TNF-alpha	104,113	Interleukin-1beta	0,17	TNF-alpha	Interleukin-1beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Interleukin-1beta system -LRB- ligand , receptor type I , receptor accessory protein and receptor antagonist -RRB- , TNF-alpha , TGF-beta1 and neuropeptide_Y mRNAs in specific brain regions during bacterial LPS-induced anorexia .
18176176	0	TNF-alpha	51,60	Interleukin-6	0,13	TNF-alpha	Interleukin-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
10484681	0	TNF-alpha	24,33	Interleukin_10	0,14	TNF-alpha	Interleukin 10	7124	3586	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin_10 inhibits TNF-alpha production in human monocytes independently of interleukin 12 and interleukin_1_beta .
11353829	0	TNF-alpha	28,37	JNK	52,55	TNF-alpha	JNK	7124	5599	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Fluid shear stress inhibits TNF-alpha activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells : Inhibitory crosstalk among MAPK family members .
16516830	0	TNF-alpha	20,29	JNK	71,74	TNF-alpha	JNK	7124	5599	Gene	Gene	cytotoxicity|amod|START_ENTITY itch|nmod|cytotoxicity itch|dep|factor factor|dep|determines determines|dobj|action action|compound|END_ENTITY	A five-year itch in TNF-alpha cytotoxicity : the time factor determines JNK action .
18097057	0	TNF-alpha	28,37	JNK	54,57	TNF-alpha	JNK	7124	5599	Gene	Gene	kinase|nmod|START_ENTITY Activation|nmod|kinase required|nsubjpass|Activation required|nmod|activation activation|compound|END_ENTITY	Activation of Rho kinase by TNF-alpha is required for JNK activation in human pulmonary microvascular endothelial cells .
18297686	0	TNF-alpha	0,9	JNK	83,86	TNF-alpha	JNK	7124	5599	Gene	Gene	represses|nsubj|START_ENTITY represses|nmod|keratinocytes keratinocytes|nmod|activation activation|nmod|signaling signaling|compound|END_ENTITY	TNF-alpha represses connexin43 expression in HaCat keratinocytes via activation of JNK signaling .
20371967	0	TNF-alpha	81,90	JNK	33,36	TNF-alpha	JNK	21926(Tax:10090)	26419(Tax:10090)	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY regulating|dobj|tumor_necrosis_factor-alpha Role|acl|regulating Role|appos|END_ENTITY	Role of c-Jun N-terminal kinase -LRB- JNK -RRB- in regulating tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- mediated increase of acetaminophen -LRB- APAP -RRB- and chlorpromazine -LRB- CPZ -RRB- toxicity in murine hepatocytes .
15908180	0	TNF-alpha	46,55	JNK/SAPK	26,34	TNF-alpha	JNK/SAPK	7124	5599;5601	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma : apoptosis of pancreatic beta-cells via the p53 and ROS pathway .
9343388	0	TNF-alpha	144,153	JNK/SAPK	226,234	TNF-alpha	JNK/SAPK	7124	5599;5601	Gene	Gene	translation|appos|START_ENTITY stimulation|nmod|translation required|nmod|stimulation required|ccomp|inhibit inhibit|advcl|blocking blocking|dobj|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
9343388	0	TNF-alpha	144,153	JNK/SAPK	55,63	TNF-alpha	JNK/SAPK	7124	5599;5601	Gene	Gene	translation|appos|START_ENTITY stimulation|nmod|translation required|nmod|stimulation required|nsubjpass|kinase kinase|appos|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
9343388	0	TNF-alpha	192,201	JNK/SAPK	226,234	TNF-alpha	JNK/SAPK	7124	5599;5601	Gene	Gene	translation|amod|START_ENTITY inhibit|dobj|translation inhibit|advcl|blocking blocking|dobj|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
9343388	0	TNF-alpha	192,201	JNK/SAPK	55,63	TNF-alpha	JNK/SAPK	7124	5599;5601	Gene	Gene	translation|amod|START_ENTITY inhibit|dobj|translation required|ccomp|inhibit required|nsubjpass|kinase kinase|appos|END_ENTITY	Jun_N-terminal_kinase / stress-activated protein kinase -LRB- JNK/SAPK -RRB- is required for lipopolysaccharide stimulation of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- translation : glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK .
20552320	0	TNF-alpha	40,49	JNK1	19,23	TNF-alpha	JNK1	7124	5599	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Distinct roles for JNK1 and JNK3 during TNF-alpha - or etoposide-induced apoptosis in HeLa cells .
15859550	0	TNF-alpha	70,79	L-selectin	15,25	TNF-alpha	L-selectin	7124	6402	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of L-selectin on the surface of neutrophils stimulated by TNF-alpha and level of sL-selectin in serum of patients with lung_cancer -RSB- .
25782587	0	TNF-alpha	17,26	LATS2	0,5	TNF-alpha	LATS2	7124	26524	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral_squamous_cell_carcinoma .
7759886	0	TNF-alpha	78,87	LFA-1	117,122	TNF-alpha	LFA-1	24835(Tax:10116)	308995(Tax:10116)	Gene	Gene	utilizes|nsubj|START_ENTITY utilizes|dobj|END_ENTITY	In vivo blood monocyte migration to acute inflammatory reactions , IL-1_alpha , TNF-alpha , IFN-gamma , and C5a utilizes LFA-1 , Mac-1 , and VLA-4 .
16954198	0	TNF-alpha	12,21	LITAF	30,35	TNF-alpha	LITAF	21926(Tax:10090)	56722(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	LPS-induced TNF-alpha factor -LRB- LITAF -RRB- - deficient mice express reduced LPS-induced cytokine : Evidence for LITAF-dependent LPS signaling pathways .
18554501	0	TNF-alpha	77,86	LITAF	95,100	TNF-alpha	LITAF	7124	9516	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Identification and characterization of a putative lipopolysaccharide-induced TNF-alpha factor -LRB- LITAF -RRB- homolog from Singapore_grouper_iridovirus .
17868983	0	TNF-alpha	37,46	LOX-1	17,22	TNF-alpha	LOX-1	7124	4973	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of LOX-1 expression by TNF-alpha promotes trans-endothelial migration of MDA-MB-231 breast_cancer cells .
11163183	0	TNF-alpha	0,9	LPS	23,26	TNF-alpha	LPS	21926(Tax:10090)	21898(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway .
11715476	0	TNF-alpha	54,63	LPS	47,50	TNF-alpha	LPS	7124	3664	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The role of activation of p38 MAPK induced by LPS in TNF-alpha gene expression -RSB- .
9766626	0	TNF-alpha	135,144	LPS	90,93	TNF-alpha	LPS	21926(Tax:10090)	21898(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Ionizing radiation potentiates the induction of nitric_oxide_synthase by IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha .
15979653	0	TNF-alpha	16,25	Leptin	0,6	TNF-alpha	Leptin	24835(Tax:10116)	25608(Tax:10116)	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells .
17007883	0	TNF-alpha	0,9	Lnk	18,21	TNF-alpha	Lnk	7124	10019	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells .
10072520	0	TNF-alpha	95,104	Lymphocyte_activation_gene-3	0,28	TNF-alpha	Lymphocyte activation gene-3	7124	3902	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Lymphocyte_activation_gene-3 , a MHC class II ligand expressed on activated T cells , stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells .
16424170	0	TNF-alpha	22,31	MAPK-activated_protein_kinase_2	97,128	TNF-alpha	MAPK-activated protein kinase 2	7124	9261	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated_protein_kinase_2 .
11481030	0	TNF-alpha	0,9	MAdCAM-1	30,38	TNF-alpha	MAdCAM-1	7124	8174	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TNF-alpha induced endothelial MAdCAM-1 expression is regulated by exogenous , not endogenous nitric_oxide .
21591983	0	TNF-alpha	17,26	MBL	64,67	TNF-alpha	MBL	7124	50639	Gene	Gene	GPIA|compound|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
10331497	0	TNF-alpha	91,100	MCP-1	0,5	TNF-alpha	MCP-1	7124	6347	Gene	Gene	plays|nsubj|START_ENTITY expressed|parataxis|plays expressed|nsubjpass|END_ENTITY	MCP-1 is selectively expressed in the late phase by cytokine-stimulated human neutrophils : TNF-alpha plays a role in maximal MCP-1 mRNA expression .
10331497	0	TNF-alpha	91,100	MCP-1	125,130	TNF-alpha	MCP-1	7124	6347	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|expression expression|compound|END_ENTITY	MCP-1 is selectively expressed in the late phase by cytokine-stimulated human neutrophils : TNF-alpha plays a role in maximal MCP-1 mRNA expression .
11027549	0	TNF-alpha	0,9	MCP-1	25,30	TNF-alpha	MCP-1	7124	6347	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expression expression|compound|END_ENTITY	TNF-alpha stimulation of MCP-1 expression is mediated by the Akt/PKB signal transduction pathway in vascular endothelial cells .
12923954	0	TNF-alpha	47,56	MCP-1	40,45	TNF-alpha	MCP-1	7124	6347	Gene	Gene	Il-10|dep|START_ENTITY Il-10|dep|END_ENTITY	-LSB- Selected cytokines -LRB- Il-6 , Il-8 , Il-10 , MCP-1 , TNF-alpha -RRB- in children and adolescents with atherosclerosis risk factors : obesity , hypertension , diabetes -RSB- .
14736953	0	TNF-alpha	40,49	MCP-1	58,63	TNF-alpha	MCP-1	7124	6347	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Dexamethasone regulates AP-1 to repress TNF-alpha induced MCP-1 production in human glomerular endothelial cells .
18976114	0	TNF-alpha	138,147	MCP-1	155,160	TNF-alpha	MCP-1	24835(Tax:10116)	100360872	Gene	Gene	glucose|compound|START_ENTITY glucose|appos|END_ENTITY	Curcumin supplementation lowers TNF-alpha , IL-6 , IL-8 , and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha , IL-6 , MCP-1 , glucose , and glycosylated hemoglobin in diabetic rats .
19107603	0	TNF-alpha	50,59	MCP-1	68,73	TNF-alpha	MCP-1	7124	6347	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	c-Jun_N-terminal_kinases inhibitor suppresses the TNF-alpha induced MCP-1 expression in human umbilical vein endothelial cells .
19379593	0	TNF-alpha	12,21	MCP-1	25,30	TNF-alpha	MCP-1	7124	6347	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of TNF-alpha on MCP-1 and IL-8 mRNA expression in human umbilical vein endothelial cells -RSB- .
22611924	0	TNF-alpha	72,81	MCP-1	47,52	TNF-alpha	MCP-1	7124	6347	Gene	Gene	induced|nmod|START_ENTITY Effects|acl|induced Effects|nmod|citreoviridin citreoviridin|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of citreoviridin on the expression of MCP-1 and ILs induced by TNF-alpha in vein endothelial cells -RSB- .
9085256	0	TNF-alpha	0,9	MIF	29,32	TNF-alpha	MIF	24835(Tax:10116)	81683(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNF-alpha up-regulates renal MIF expression in rat crescentic glomerulonephritis .
11704541	0	TNF-alpha	65,74	MMP-9	13,18	TNF-alpha	MMP-9	7124	4318	Gene	Gene	epithelial|nmod|START_ENTITY epithelial|nsubj|Induction Induction|nmod|END_ENTITY	Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa_B-mediated pathway .
14516792	0	TNF-alpha	96,105	MMP-9	69,74	TNF-alpha	MMP-9	7124	4318	Gene	Gene	induced|nmod|START_ENTITY secretion|acl|induced secretion|compound|END_ENTITY	The inhibition of MAPK pathway is correlated with down-regulation of MMP-9 secretion induced by TNF-alpha in human keratinocytes .
15273742	0	TNF-alpha	0,9	MMP-9	45,50	TNF-alpha	MMP-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|alphavbeta6 alphavbeta6|compound|END_ENTITY	TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion .
15458430	0	TNF-alpha	0,9	MMP-9	46,51	TNF-alpha	MMP-9	7124	4318	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	TNF-alpha and IL-1beta-mediated regulation of MMP-9 and TIMP-1 in renal proximal tubular cells .
15855236	0	TNF-alpha	81,90	MMP-9	58,63	TNF-alpha	MMP-9	7124	4318	Gene	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	Breast_cancer cells induce stromal fibroblasts to express MMP-9 via secretion of TNF-alpha and TGF-beta .
17158602	0	TNF-alpha	0,9	MMP-9	18,23	TNF-alpha	MMP-9	7124	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TNF-alpha induces MMP-9 expression via activation of Src/EGFR , PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells .
17890880	0	TNF-alpha	0,9	MMP-9	47,52	TNF-alpha	MMP-9	7124	4318	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	TNF-alpha and IL-1_beta-mediated regulation of MMP-9 and TIMP-1 in human glomerular mesangial cells .
18606251	0	TNF-alpha	63,72	MMP-9	92,97	TNF-alpha	MMP-9	7124	4318	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Astilbin inhibits the adhesion of T lymphocytes via decreasing TNF-alpha and its associated MMP-9 activity and CD44 expression .
18773430	0	TNF-alpha	174,183	MMP-9	154,159	TNF-alpha	MMP-9	7124	4318	Gene	Gene	HASMC|compound|START_ENTITY expression|nmod|HASMC expression|compound|END_ENTITY	3,4,5-trihydroxybenzaldehyde from Geum japonicum has dual inhibitory effect on matrix_metalloproteinase_9 ; inhibition of gelatinoytic activity as well as MMP-9 expression in TNF-alpha induced HASMC .
18824875	0	TNF-alpha	28,37	MMP-9	93,98	TNF-alpha	MMP-9	7124	4318	Gene	Gene	involvement|nmod|START_ENTITY changes|nsubj|involvement changes|nmod|cell cell|amod|END_ENTITY	Nitric_oxide involvement in TNF-alpha and IL-1_beta-mediated changes in human mesangial cell MMP-9 and TIMP-1 .
21502320	0	TNF-alpha	83,92	MMP-9	135,140	TNF-alpha	MMP-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|nmod|matrix_metalloproteinase-9 matrix_metalloproteinase-9|appos|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
9743290	0	TNF-alpha	43,52	MMP-9	23,28	TNF-alpha	MMP-9	7124	4318	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor -LRB- MMPSF -RRB- .
17575006	0	TNF-alpha	0,9	MUC1	18,22	TNF-alpha	MUC1	7124	4582	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	TNF-alpha induces MUC1 gene transcription in lung epithelial cells : its signaling pathway and biological implication .
11580144	0	TNF-alpha	45,54	Macrophage_inflammatory_protein-2	0,33	TNF-alpha	Macrophage inflammatory protein-2	21926(Tax:10090)	20310(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Macrophage_inflammatory_protein-2 induced by TNF-alpha plays a pivotal role in concanavalin A-induced liver_injury in mice .
17362932	0	TNF-alpha	37,46	Matrix_metalloproteinase-9	0,26	TNF-alpha	Matrix metalloproteinase-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Matrix_metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal , glial cells and its absence extends life in a transgenic mouse model of amyotrophic_lateral_sclerosis .
10465100	0	TNF-alpha	171,180	MnSOD	58,63	TNF-alpha	MnSOD	21926(Tax:10090)	20656(Tax:10090)	Gene	Gene	mRNA|nmod|START_ENTITY modulation|nmod|mRNA therapy|dep|modulation plasmid/liposome|dep|therapy plasmid/liposome|nsubj|correction correction|appos|END_ENTITY	Manganese -LSB- correction of Magnesium -RSB- superoxide dismutase -LRB- MnSOD -RRB- plasmid/liposome pulmonary radioprotective gene therapy : modulation of irradiation-induced mRNA for IL-I , TNF-alpha , and TGF-beta correlates with delay of organizing_alveolitis / fibrosis .
12032862	0	TNF-alpha	25,34	MnSOD	43,48	TNF-alpha	MnSOD	7124	6648	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Tamoxifen enhancement of TNF-alpha induced MnSOD expression : modulation of NF-kappaB dimerization .
12829021	0	TNF-alpha	125,134	MnSOD	68,73	TNF-alpha	MnSOD	7124	6648	Gene	Gene	prevents|nmod|START_ENTITY cl|ccomp|prevents cl|nsubj|Overexpression Overexpression|nmod|transgene transgene|nmod|dismutase dismutase|appos|END_ENTITY	Overexpression of the transgene for manganese_superoxide dismutase -LRB- MnSOD -RRB- in 32D cl 3 cells prevents apoptosis induction by TNF-alpha , IL-3 withdrawal , and ionizing radiation .
8877395	0	TNF-alpha	85,94	Monoclonal_nonspecific_suppressor_factor_beta	0,45	TNF-alpha	Monoclonal nonspecific suppressor factor beta	21926(Tax:10090)	14109(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Monoclonal_nonspecific_suppressor_factor_beta -LRB- MNSF_beta -RRB- inhibits the production of TNF-alpha by lipopolysaccharide-activated macrophages .
10440583	0	TNF-alpha	34,43	NF-kappaB	52,61	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	The role of superoxide radical in TNF-alpha induced NF-kappaB activation .
11003979	0	TNF-alpha	47,56	NF-kappaB	0,9	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	induced|nmod|START_ENTITY loss|acl|induced mediates|dobj|loss mediates|nsubj|END_ENTITY	NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal_muscle_myotubes .
11045427	0	TNF-alpha	32,41	NF-kappaB	0,9	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	sensitivity|amod|START_ENTITY predetermine|dobj|sensitivity predetermine|nsubj|kinetics kinetics|amod|END_ENTITY	NF-kappaB kinetics predetermine TNF-alpha sensitivity of colorectal_cancer cells .
12145100	0	TNF-alpha	0,9	NF-kappaB	148,157	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|expression expression|dep|requirement requirement|nmod|pathways pathways|compound|END_ENTITY	TNF-alpha , inefficient by itself , potentiates IL-1beta-induced PGHS-2 expression in human pulmonary microvascular endothelial cells : requirement of NF-kappaB and p38 MAPK pathways .
12213594	0	TNF-alpha	42,51	NF-kappaB	84,93	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|nuclear_factor-kappaB nuclear_factor-kappaB|dep|END_ENTITY	Reduction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- related nuclear_factor-kappaB -LRB- NF-kappaB -RRB- translocation but not inhibitor kappa-B -LRB- Ikappa-B -RRB- - degradation by Rho protein inhibition in human endothelial cells .
12663241	0	TNF-alpha	133,142	NF-kappaB	94,103	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	roles|nmod|START_ENTITY Tumor_necrosis_factor_alpha|dep|roles Tumor_necrosis_factor_alpha|dep|expression expression|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
12663241	0	TNF-alpha	29,38	NF-kappaB	94,103	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	Tumor_necrosis_factor_alpha|appos|START_ENTITY Tumor_necrosis_factor_alpha|dep|expression expression|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
14646597	0	TNF-alpha	29,38	NF-kappaB	0,9	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY involved|nmod|inhibition involved|nsubjpass|END_ENTITY	NF-kappaB is involved in the TNF-alpha induced inhibition of the differentiation of 3T3-L1 cells by reducing PPARgamma expression .
14963056	0	TNF-alpha	43,52	NF-kappaB	78,87	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	expression|amod|START_ENTITY prevents|dobj|expression prevents|advcl|preventing preventing|dobj|activation activation|amod|END_ENTITY	Eicosapentaenoic_acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation .
15597152	0	TNF-alpha	119,128	NF-kappaB	0,9	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	co-secreted|nmod|START_ENTITY signals|acl|co-secreted potentiated|nmod|signals potentiated|nsubjpass|translocation translocation|amod|END_ENTITY	NF-kappaB translocation and endothelial cell activation is potentiated by macrophage-released signals co-secreted with TNF-alpha and IL-1beta .
15601669	0	TNF-alpha	76,85	NF-kappaB	103,112	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced Fas|dobj|expression leading|xcomp|Fas pathways|acl|leading signaling|dobj|pathways Characterization|acl|signaling Characterization|dep|role role|nmod|END_ENTITY	Characterization of signaling pathways leading to Fas expression induced by TNF-alpha : pivotal role of NF-kappaB .
15665513	0	TNF-alpha	0,9	NF-kappaB	43,52	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation .
15980040	0	TNF-alpha	51,60	NF-kappaB	114,123	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nmod|modulation modulation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation .
16000198	0	TNF-alpha	97,106	NF-kappaB	0,9	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	cytotoxicity|amod|START_ENTITY protection|nmod|cytotoxicity required|nmod|protection required|advmod|END_ENTITY	NF-kappaB activation but not PI3K/Akt is required for dexamethasone dependent protection against TNF-alpha cytotoxicity in L929 cells .
16075467	0	TNF-alpha	62,71	NF-kappaB	30,39	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	feasibility|dep|START_ENTITY feasibility|nmod|cytokines cytokines|amod|END_ENTITY	The feasibility of monitoring NF-kappaB associated cytokines : TNF-alpha , IL-1alpha , IL-6 , and IL-8 in whole saliva for the malignant_transformation_of_oral_lichen_planus .
16199483	0	TNF-alpha	108,117	NF-kappaB	29,38	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	overexpressing|dobj|START_ENTITY mice|acl|overexpressing associated|nmod|mice associated|nsubjpass|Cardioprotection Cardioprotection|acl|afforded afforded|nmod|ablation ablation|amod|END_ENTITY	Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha .
16428340	0	TNF-alpha	67,76	NF-kappaB	22,31	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	activated|nmod|START_ENTITY translocation|acl|activated translocation|amod|END_ENTITY	Rapamycin antagonizes NF-kappaB nuclear translocation activated by TNF-alpha in primary vascular smooth muscle cells and enhances apoptosis .
16584809	0	TNF-alpha	0,9	NF-kappaB	32,41	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	TNF-alpha mediated transport of NF-kappaB to the nucleus is independent of the cytoskeleton-based transport system in non-neuronal cells .
16595893	0	TNF-alpha	67,76	NF-kappaB	44,53	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	activated|nmod|START_ENTITY activated|nsubj|effect effect|nmod|pitavastatin pitavastatin|nmod|END_ENTITY	Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular_carcinoma cells .
16784892	0	TNF-alpha	19,28	NF-kappaB	59,68	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	loop|amod|START_ENTITY loop|nmod|END_ENTITY	Involvement of the TNF-alpha autocrine-paracrine loop , via NF-kappaB and YY1 , in the regulation of tumor cell resistance to Fas-induced apoptosis .
16879221	0	TNF-alpha	0,9	NF-kappaB	112,121	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	suppression|amod|START_ENTITY END_ENTITY|nsubj|suppression	TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB - and p38_MAPK-dependent .
17321745	0	TNF-alpha	27,36	NF-kappaB	123,132	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nmod|cells cells|acl|blocking blocking|dobj|activation activation|amod|END_ENTITY	A_chromone analog inhibits TNF-alpha induced expression of cell adhesion molecules on human endothelial cells via blocking NF-kappaB activation .
17334236	0	TNF-alpha	0,9	NF-kappaB	31,40	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|PTEN PTEN|nmod|END_ENTITY	TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells .
17339489	0	TNF-alpha	97,106	NF-kappaB	24,33	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	relevance|nmod|START_ENTITY study|dep|relevance study|nmod|activation activation|amod|END_ENTITY	A quantitative study of NF-kappaB activation by H2O2 : relevance in inflammation and synergy with TNF-alpha .
17374495	0	TNF-alpha	102,111	NF-kappaB	14,23	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	cells|amod|START_ENTITY nitric_oxide|nmod|cells nitric_oxide|nsubj|Regulation Regulation|nmod|activation activation|amod|END_ENTITY	Regulation of NF-kappaB activation and nuclear translocation by exogenous nitric_oxide -LRB- NO -RRB- donors in TNF-alpha activated vascular endothelial cells .
17481363	0	TNF-alpha	93,102	NF-kappaB	29,38	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	cells|appos|START_ENTITY Analysis|nmod|cells Analysis|nmod|translocation translocation|amod|END_ENTITY	Analysis and quantitation of NF-kappaB nuclear translocation in tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- activated vascular endothelial cells .
17764673	0	TNF-alpha	18,27	NF-kappaB	108,117	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	adhesion|amod|START_ENTITY adhesion|nmod|activation activation|amod|neutrophils neutrophils|xcomp|endothelial endothelial|nmod|suppression suppression|nmod|END_ENTITY	Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation .
17879952	0	TNF-alpha	106,115	NF-kappaB	50,59	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	induced|nmod|START_ENTITY induced|dobj|activation activation|amod|END_ENTITY	Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha .
17879952	0	TNF-alpha	32,41	NF-kappaB	50,59	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activation activation|amod|END_ENTITY	Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha .
18537078	0	TNF-alpha	53,62	NF-kappaB	122,131	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nmod|macrophages macrophages|nmod|suppression suppression|nmod|END_ENTITY	Hinokitiol , a natural tropolone derivative , inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB .
18550789	0	TNF-alpha	14,23	NF-kappaB	108,117	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dep|signaling signaling|dobj|death death|nmod|pathway pathway|amod|END_ENTITY	Transmembrane TNF-alpha mediates `` forward '' and `` reverse '' signaling , inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt_lymphoma cells .
19038972	0	TNF-alpha	0,9	NF-kappaB	48,57	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|MAPK MAPK|amod|END_ENTITY	TNF-alpha reduces PGC-1alpha expression through NF-kappaB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model .
19113817	0	TNF-alpha	69,78	NF-kappaB	56,65	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	facilitates|nmod|START_ENTITY facilitates|dobj|induction induction|nmod|END_ENTITY	Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha .
19393729	0	TNF-alpha	70,79	NF-kappaB	122,131	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY COX-2|appos|expression COX-2|acl:relcl|mediated mediated|nmod|regulation regulation|amod|END_ENTITY	Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2 , TNF-alpha and iNOS expression , which is mediated by NF-kappaB regulation , in RAW264 .7 cells .
19602845	0	TNF-alpha	29,38	NF-kappaB	73,82	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	Tumor_necrosis_factor-alpha|appos|START_ENTITY induces|nsubj|Tumor_necrosis_factor-alpha induces|dobj|upregulation upregulation|nmod|RhoA RhoA|nmod|activation activation|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells .
19995599	0	TNF-alpha	35,44	NF-kappaB	63,72	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	inhibitor|amod|START_ENTITY acts|nmod|inhibitor acts|nmod|END_ENTITY	Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB .
20372995	0	TNF-alpha	144,153	NF-kappaB	176,185	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	activation|amod|START_ENTITY lymphocytes|nmod|activation protecting|dobj|lymphocytes example|acl|protecting example|nmod|END_ENTITY	Critical need for clinical trials : an example of a pilot human intervention trial of a mixture of natural agents protecting lymphocytes against TNF-alpha induced activation of NF-kappaB .
20567236	0	TNF-alpha	60,69	NF-kappaB	123,132	TNF-alpha	NF-kappaB	7124	4790	Gene	Gene	adipocytes|nmod|START_ENTITY deletion|nmod|adipocytes Selective|dobj|deletion Selective|nmod|suppression suppression|nmod|END_ENTITY	Selective deletion of adipocytes , but not preadipocytes , by TNF-alpha through C/EBP - and PPARgamma-mediated suppression of NF-kappaB .
21196314	0	TNF-alpha	0,9	NF-kappaB	19,28	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	TNF-alpha mediated NF-kappaB activation is constantly extended by transglutaminase_2 .
23578838	0	TNF-alpha	60,69	NF-kappaB	16,25	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY astrocytes|dobj|expression astrocytes|nsubj|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
23947625	0	TNF-alpha	60,69	NF-kappaB	16,25	TNF-alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY astrocytes|dobj|expression astrocytes|nsubj|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
10640779	0	TNF-alpha	21,30	NF-kappa_B	0,10	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	production|amod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	NF-kappa_B modulates TNF-alpha production by alveolar macrophages in asymptomatic HIV-seropositive individuals .
10754326	0	TNF-alpha	0,9	NF-kappa_B	56,66	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|macrophages macrophages|dep|regulation regulation|nmod|END_ENTITY	TNF-alpha gene expression in macrophages : regulation by NF-kappa_B is independent of c-Jun or C/EBP _ beta .
10759767	0	TNF-alpha	98,107	NF-kappa_B	40,50	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|salts salts|nmod|mobilization mobilization|amod|END_ENTITY	Effects of anti-rheumatic gold salts on NF-kappa_B mobilization and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- - induced neutrophil-dependent cytotoxicity for human endothelial cells .
11368927	0	TNF-alpha	80,89	NF-kappa_B	55,65	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	prevents|nmod|START_ENTITY prevents|dobj|activation activation|amod|END_ENTITY	Soy isoflavone supplementation in healthy men prevents NF-kappa_B activation by TNF-alpha in blood lymphocytes .
11420928	0	TNF-alpha	0,9	NF-kappa_B	20,30	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	TNF-alpha dependent NF-kappa_B activation in cultured canine keratinocytes is partly mediated by reactive oxygen species .
11489936	0	TNF-alpha	0,9	NF-kappa_B	39,49	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	mediates|amod|START_ENTITY SDF-1|nsubj|mediates SDF-1|dobj|activation activation|amod|END_ENTITY	TNF-alpha mediates SDF-1 alpha-induced NF-kappa_B activation and cytotoxic effects in primary astrocytes .
12061837	0	TNF-alpha	12,21	NF-kappa_B	65,75	TNF-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|regulation regulation|nmod|evidence evidence|dep|signaling signaling|dep|END_ENTITY	Recombinant TNF-alpha mediated regulation of the I_kappa_B-alpha / NF-kappa_B signaling pathway : evidence for the enhancement of pro- and anti-inflammatory cytokines in alveolar epithelial cells .
12388359	0	TNF-alpha	82,91	NF-kappa_B	0,10	TNF-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY modulates|dobj|transcription _|ccomp|modulates _|nsubj|inhibition inhibition|amod|END_ENTITY	NF-kappa_B inhibition by omega _ -3 _ fatty_acids modulates LPS-stimulated macrophage TNF-alpha transcription .
12508545	0	TNF-alpha	90,99	NF-kappa_B	11,21	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	-RSB-|compound|START_ENTITY induced|nmod|-RSB- induced|nsubj|Effect Effect|nmod|pathway pathway|amod|END_ENTITY	-LSB- Effect of NF-kappa_B pathway on apoptosis of hepatic_carcinoma cell line-7721 induced by TNF-alpha -RSB- .
12684057	0	TNF-alpha	0,9	NF-kappa_B	81,91	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|cardiomyocytes cardiomyocytes|nmod|activation activation|amod|END_ENTITY	TNF-alpha and H2O2 induce IL-18 and IL-18R_beta expression in cardiomyocytes via NF-kappa_B activation .
14530313	0	TNF-alpha	22,31	NF-kappa_B	86,96	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	effects|nmod|START_ENTITY effects|dep|activation activation|compound|END_ENTITY	Functional effects of TNF-alpha on a human follicular dendritic cell line : persistent NF-kappa_B activation and sensitization for Fas-mediated apoptosis .
15557189	0	TNF-alpha	22,31	NF-kappa_B	71,81	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	regulation|amod|START_ENTITY mechanism|nmod|regulation mechanism|dep|involvement involvement|nmod|END_ENTITY	A novel mechanism for TNF-alpha regulation by p38 MAPK : involvement of NF-kappa_B with implications for therapy in rheumatoid_arthritis .
15694363	0	TNF-alpha	0,9	NF-kappa_B	89,99	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|fibroblasts fibroblasts|nmod|pathway pathway|compound|END_ENTITY	TNF-alpha modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-kappa_B signalling pathway .
18182252	0	TNF-alpha	27,36	NF-kappa_B	45,55	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activation activation|amod|END_ENTITY	Alpha-lipoic_acid inhibits TNF-alpha induced NF-kappa_B activation through blocking of MEKK1-MKK4-IKK signaling cascades .
7583354	0	TNF-alpha	48,57	NF-kappa_B	21,31	TNF-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	accumulation|amod|START_ENTITY correlates|nmod|accumulation correlates|nsubj|migration migration|nmod|END_ENTITY	Nuclear migration of NF-kappa_B correlates with TNF-alpha mRNA accumulation .
7608567	0	TNF-alpha	40,49	NF-kappa_B	109,119	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	promoter|amod|START_ENTITY activation|nmod|promoter activation|dep|role role|nmod|END_ENTITY	Transcriptional activation of the human TNF-alpha promoter by superantigen in human monocytic cells : role of NF-kappa_B .
8490102	0	TNF-alpha	117,126	NF-kappa_B	48,58	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	affecting|nmod|START_ENTITY affecting|dobj|mRNA mRNA|amod|END_ENTITY	One and two-level regulation patterns affecting NF-kappa_B mRNA and nuclear NF-kappa_B activity after treatment with TNF-alpha , IFN-gamma and IL-4 .
8873967	0	TNF-alpha	106,115	NF-kappa_B	42,52	TNF-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY mediator|nmod|response mediator|nsubj|translocation translocation|nmod|END_ENTITY	Ceramide-induced nuclear translocation of NF-kappa_B is a potential mediator of the apoptotic response to TNF-alpha in murine clonal_osteoblasts .
9035283	0	TNF-alpha	89,98	NF-kappa_B	14,24	TNF-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY suppression|nmod|transcription correlates|nmod|suppression correlates|nsubj|Inhibition Inhibition|nmod|activation activation|amod|END_ENTITY	Inhibition of NF-kappa_B activation by dimethyl_sulfoxide correlates with suppression of TNF-alpha formation , reduced ICAM-1 gene transcription , and protection against endotoxin-induced liver_injury .
9415036	0	TNF-alpha	48,57	NF-kappa_B	102,112	TNF-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|presence presence|nmod|END_ENTITY	Tosylphenylalanine_chloromethyl_ketone inhibits TNF-alpha mRNA synthesis in the presence of activated NF-kappa_B in RAW 264.7 macrophages .
9486215	0	TNF-alpha	45,54	NF-kappa_B	88,98	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of surfactant proteins A and B by TNF-alpha and phorbol_ester independent of NF-kappa_B .
9521860	0	TNF-alpha	0,9	NF-kappa_B	128,138	TNF-alpha	NF-kappa B	7124	4790	Gene	Gene	expression|amod|START_ENTITY expression|dep|evidence evidence|nmod|interaction interaction|nmod|receptors receptors|nmod|END_ENTITY	TNF-alpha and 9-cis-retinoic_acid synergistically induce ICAM-1 expression : evidence for interaction of retinoid receptors with NF-kappa_B .
9875227	0	TNF-alpha	144,153	NF-kappa_B	121,131	TNF-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulation|dep|START_ENTITY regulation|nmod|expression expression|nmod|subunits subunits|amod|END_ENTITY	Glutathione downregulates the phosphorylation of I kappa B : autoloop regulation of the NF-kappa_B-mediated expression of NF-kappa_B subunits by TNF-alpha in mouse vascular endothelial cells .
11404390	0	TNF-alpha	30,39	Nerve_growth_factor	0,19	TNF-alpha	Nerve growth factor	21926(Tax:10090)	18049(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Nerve_growth_factor regulates TNF-alpha production in mouse macrophages via MAP kinase activation .
23241117	0	TNF-alpha	27,36	OPG	44,47	TNF-alpha	OPG	7124	4982	Gene	Gene	RANKL|compound|START_ENTITY RANKL|appos|END_ENTITY	Changes in serum levels of TNF-alpha , IL-6 , OPG , RANKL and their correlation with radiographic and clinical assessment in fragility_fractures and high energy fractures .
10899315	0	TNF-alpha	31,40	P-selectin	85,95	TNF-alpha	P-selectin	7124	6403	Gene	Gene	induction|nmod|START_ENTITY release|nsubj|induction release|nmod|END_ENTITY	Density-dependent induction of TNF-alpha release from human monocytes by immobilized P-selectin .
18675993	0	TNF-alpha	44,53	P38	12,15	TNF-alpha	P38	7124	1432	Gene	Gene	release|amod|START_ENTITY induced|dobj|release role|acl|induced role|nmod|MAPK MAPK|compound|END_ENTITY	The role of P38 MAPK and PKC in BLP induced TNF-alpha release , apoptosis , and NFkappaB activation in THP-1 monocyte cells .
20646342	0	TNF-alpha	87,96	P38	25,28	TNF-alpha	P38	7124	1432	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|activation activation|amod|budesonide budesonide|nmod|MAPK MAPK|compound|END_ENTITY	Effects of budesonide on P38 MAPK activation , apoptosis and IL-8 secretion , induced by TNF-alpha and Haemophilus_influenzae in human bronchial epithelial cells .
12715715	0	TNF-alpha	1,10	PC-1	11,15	TNF-alpha	PC-1	7124	5310	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	-LSB- TNF-alpha PC-1 gene polymorphisms and pre-diabetes quantitative features in the Polish population -RSB- .
12044870	0	TNF-alpha	79,88	PPAR_gamma	21,31	TNF-alpha	PPAR gamma	7124	5468	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of PPAR_gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes .
18655773	0	TNF-alpha	36,45	PPARgamma	14,23	TNF-alpha	PPARgamma	7124	5468	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of PPARgamma function by TNF-alpha .
17334236	0	TNF-alpha	0,9	PTEN	22,26	TNF-alpha	PTEN	7124	5728	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells .
8490103	0	TNF-alpha	27,36	Protein_kinase_C	0,16	TNF-alpha	Protein kinase C	7124	112476	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Protein_kinase_C regulates TNF-alpha production by human monocytes .
18786965	0	TNF-alpha	117,126	RANKL	98,103	TNF-alpha	RANKL	7124	8600	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|induction induction|amod|END_ENTITY	IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17 .
18523264	0	TNF-alpha	64,73	Retinoic_acid-inducible_gene-I	0,30	TNF-alpha	Retinoic acid-inducible gene-I	21926(Tax:10090)	230073(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Retinoic_acid-inducible_gene-I mediates late phase induction of TNF-alpha by lipopolysaccharide .
19597296	0	TNF-alpha	45,54	Retinol_binding_protein-4	0,25	TNF-alpha	Retinol binding protein-4	7124	5950	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	Retinol_binding_protein-4 is associated with TNF-alpha and not insulin resistance in subjects with type_2_diabetes_mellitus and coronary_heart_disease .
11489936	0	TNF-alpha	0,9	SDF-1	19,24	TNF-alpha	SDF-1	7124	6387	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	TNF-alpha mediates SDF-1 alpha-induced NF-kappa_B activation and cytotoxic effects in primary astrocytes .
9458713	0	TNF-alpha	10,19	SMIT	23,27	TNF-alpha	SMIT	280943(Tax:9913)	282362(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells .
12114204	0	TNF-alpha	0,9	SP-A	19,23	TNF-alpha	SP-A	7124	653509	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK .
17617590	0	TNF-alpha	35,44	STAT-6	101,107	TNF-alpha	STAT-6	7124	6778	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	IL-4 and IL-13 negatively regulate TNF-alpha - and IFN-gamma-induced beta-defensin expression through STAT-6 , suppressor_of_cytokine_signaling _ -LRB- SOCS -RRB- -1 , and SOCS-3 .
22506067	0	TNF-alpha	25,34	STAT3	0,5	TNF-alpha	STAT3	7124	6774	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass .
7683320	0	TNF-alpha	34,43	Substance_P	0,11	TNF-alpha	Substance P	21926(Tax:10090)	21333(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Substance_P selectively activates TNF-alpha gene expression in murine mast cells .
17264149	0	TNF-alpha	16,25	TACE	0,4	TNF-alpha	TACE	21926(Tax:10090)	11491(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	TACE release of TNF-alpha mediates mechanotransduction-induced activation of p38_MAPK and myogenesis .
11323220	0	TNF-alpha	33,42	TARC	51,55	TNF-alpha	TARC	7124	6361	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells : a possible mechanism in the inflammatory reaction of atopic_dermatitis .
12441140	0	TNF-alpha	152,161	TARC	31,35	TNF-alpha	TARC	7124	6361	Gene	Gene	CXCL10|nmod|START_ENTITY CXCL10|nsubj|END_ENTITY	IL-4 , but not IL-13 , modulates TARC -LRB- thymus_and_activation-regulated_chemokine -RRB- / CCL17 and IP-10 -LRB- interferon-induced_protein_of_10kDA -RRB- / CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line .
20185925	0	TNF-alpha	37,46	TARC	73,77	TNF-alpha	TARC	7124	6361	Gene	Gene	cytokines|amod|START_ENTITY induces|nsubj|cytokines induces|dobj|production production|compound|END_ENTITY	Combined stimulation with Poly -LRB- I : C -RRB- , TNF-alpha and Th2 cytokines induces TARC production by human fibroblasts from the nose , bronchioles and lungs .
16730711	0	TNF-alpha	39,48	TC1	0,3	TNF-alpha	TC1	7124	56892	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	TC1 -LRB- C8orf4 -RRB- is upregulated by IL-1beta / TNF-alpha and enhances proliferation of human follicular dendritic cells .
8332347	0	TNF-alpha	72,81	TFG-alpha	121,130	TNF-alpha	TFG-alpha	7124	7039	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY tumor_necrosis_factor-alpha|appos|END_ENTITY	-LSB- Creation of monoclonal antibodies against tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and transforming_growth_factor_alpha -LRB- TFG-alpha -RRB- , their definition and possible use -RSB- .
10193415	0	TNF-alpha	115,124	TGF-beta	201,209	TNF-alpha	TGF-beta	21926(Tax:10090)	21803(Tax:10090)	Gene	Gene	interferon-gamma|appos|START_ENTITY effects|nmod|interferon-gamma effects|appos|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
11122238	0	TNF-alpha	39,48	TGF-beta	84,92	TNF-alpha	TGF-beta	21926(Tax:10090)	21803(Tax:10090)	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|dep|transforming transforming|dobj|factor-beta factor-beta|appos|END_ENTITY	Roles of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , transforming growth factor-beta -LRB- TGF-beta -RRB- , and IL-10 in the modulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by macrophages during mycobacterial_infection .
18252868	0	TNF-alpha	68,77	TGF-beta	29,37	TNF-alpha	TGF-beta	7124	7040	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|up-regulation up-regulation|nmod|receptor receptor|amod|END_ENTITY	LPS-induced up-regulation of TGF-beta receptor 1 is associated with TNF-alpha expression in human monocyte-derived macrophages .
7572286	0	TNF-alpha	37,46	TGF-beta	75,83	TNF-alpha	TGF-beta	24835(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of astrocyte TNF-alpha expression by the cytokines TGF-beta , IL-6 and IL-10 .
7900924	0	TNF-alpha	0,9	TGF-beta	35,43	TNF-alpha	TGF-beta	24835(Tax:10116)	59086(Tax:10116)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|synthesis synthesis|amod|END_ENTITY	TNF-alpha , TSH , and aging regulate TGF-beta synthesis and secretion in FRTL-5 rat thyroid cells .
11394717	0	TNF-alpha	90,99	TGF-beta1	10,19	TNF-alpha	TGF-beta1	21926(Tax:10090)	59086(Tax:10116)	Gene	Gene	mice|amod|START_ENTITY expression|nmod|mice END_ENTITY|dep|expression	Increased TGF-beta1 in the lungs of asbestos-exposed rats and mice : reduced expression in TNF-alpha receptor knockout mice .
11669584	0	TNF-alpha	197,206	TGF-beta1	104,113	TNF-alpha	TGF-beta1	280943(Tax:9913)	7040	Gene	Gene	stimulated|nmod|START_ENTITY Modulation|acl|stimulated Modulation|nmod|END_ENTITY	Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha .
11991675	0	TNF-alpha	21,30	TGF-beta1	43,52	TNF-alpha	TGF-beta1	7124	7040	Gene	Gene	IFN-gamma|appos|START_ENTITY Production|nmod|IFN-gamma END_ENTITY|nsubj|Production	Production of IL-10 , TNF-alpha , IFN-gamma , TGF-beta1 by different populations of erythroid cells derived from human embryonal liver .
12431778	0	TNF-alpha	48,57	TGF-beta1	0,9	TNF-alpha	TGF-beta1	21926(Tax:10090)	21803(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY caspases|acl|induced inhibits|dobj|caspases inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits multiple caspases induced by TNF-alpha in murine osteoblastic MC3T3-E1 cells .
15622443	0	TNF-alpha	0,9	TGF-beta1	11,20	TNF-alpha	TGF-beta1	7124	7040	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|IL-6 IL-6|amod|END_ENTITY	TNF-alpha , TGF-beta1 , IL-10 , IL-6 , gene polymorphisms in latent autoimmune diabetes of adults -LRB- LADA -RRB- and type 2 diabetes_mellitus .
19301076	0	TNF-alpha	23,32	TGF-beta1	0,9	TNF-alpha	TGF-beta1	7124	7040	Gene	Gene	production|amod|START_ENTITY influence|nmod|production influence|nsubj|END_ENTITY	TGF-beta1 influence on TNF-alpha production and sTNF-Rs shedding in a coculture of colon_carcinoma cell spheroids with normal cells .
20141610	0	TNF-alpha	0,9	TGF-beta1	18,27	TNF-alpha	TGF-beta1	7124	7040	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation .
9469470	0	TNF-alpha	85,94	TGF-beta1	110,119	TNF-alpha	TGF-beta1	21926(Tax:10090)	21803(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Increased mortality , blunted production of nitric_oxide , and increased production of TNF-alpha in endotoxemic TGF-beta1 transgenic_mice .
9570721	0	TNF-alpha	104,113	TGF-beta1	115,124	TNF-alpha	TGF-beta1	24835(Tax:10116)	59086(Tax:10116)	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Interleukin-1beta system -LRB- ligand , receptor type I , receptor accessory protein and receptor antagonist -RRB- , TNF-alpha , TGF-beta1 and neuropeptide_Y mRNAs in specific brain regions during bacterial LPS-induced anorexia .
11046022	0	TNF-alpha	57,66	TGF-beta_1	0,10	TNF-alpha	TGF-beta 1	21926(Tax:10090)	21803(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	TGF-beta_1 and IFN-gamma direct macrophage activation by TNF-alpha to osteoclastic or cytocidal phenotype .
21591983	0	TNF-alpha	17,26	TGF-beta_1	28,38	TNF-alpha	TGF-beta 1	7124	7040	Gene	Gene	GPIA|compound|START_ENTITY GPIA|appos|END_ENTITY	Investigation of TNF-alpha , TGF-beta_1 , IL-10 , IL-6 , IFN-gamma , MBL , GPIA , and IL1A gene polymorphisms in patients with idiopathic_thrombocytopenic_purpura .
25158571	0	TNF-alpha	74,83	THP-1	124,129	TNF-alpha	THP-1	7124	2736	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	The influence of toll-like receptor -LRB- TLR - -RRB- agonists on lysozyme activity , TNF-alpha secretion and intercellular adhesion in THP-1 cells .
17493155	0	TNF-alpha	32,41	TNF	43,46	TNF-alpha	TNF	7124	7124	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Significant association between TNF-alpha -LRB- TNF -RRB- promoter allele -LRB- -1031 C , -863 C , and -857 C -RRB- and cerebral_malaria in Thailand .
19716548	0	TNF-alpha	49,58	TNF-R	143,148	TNF-alpha	TNF-R	7124	7132	Gene	Gene	pathway|nmod|START_ENTITY Activation|nmod|pathway suggests|nsubj|Activation suggests|dobj|role role|nmod|TNF_receptor TNF_receptor|appos|END_ENTITY	Activation of the extrinsic apoptotic pathway by TNF-alpha in human salivary gland -LRB- HSG -RRB- cells in vitro , suggests a role for the TNF_receptor -LRB- TNF-R -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in Sj gren 's syndrome-associated autoimmune_sialadenitis .
10587369	0	TNF-alpha	14,23	TNF-alpha	64,73	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of TNF-alpha mRNA expression in endometrial cells by TNF-alpha and by oestrogen withdrawal .
10587369	0	TNF-alpha	64,73	TNF-alpha	14,23	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of TNF-alpha mRNA expression in endometrial cells by TNF-alpha and by oestrogen withdrawal .
10888366	0	TNF-alpha	8,17	TNF-alpha	98,107	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Role of TNF-alpha in high-dose antigen therapy in experimental autoimmune neuritis : inhibition of TNF-alpha by neutralizing antibodies reduces T-cell apoptosis and prevents liver_necrosis .
10888366	0	TNF-alpha	98,107	TNF-alpha	8,17	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Role of TNF-alpha in high-dose antigen therapy in experimental autoimmune neuritis : inhibition of TNF-alpha by neutralizing antibodies reduces T-cell apoptosis and prevents liver_necrosis .
15345185	0	TNF-alpha	34,43	TNF-alpha	44,53	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Role of the HLA-DP Glu 69 and the TNF-alpha TNF-alpha 2 gene markers in susceptibility to beryllium hypersensitivity .
15345185	0	TNF-alpha	44,53	TNF-alpha	34,43	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Role of the HLA-DP Glu 69 and the TNF-alpha TNF-alpha 2 gene markers in susceptibility to beryllium hypersensitivity .
17879952	0	TNF-alpha	106,115	TNF-alpha	32,41	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha .
17879952	0	TNF-alpha	32,41	TNF-alpha	106,115	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha .
8189599	0	TNF-alpha	11,20	TNF-alpha	130,139	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Overcoming TNF-alpha and drug resistance of human renal_cell_carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha or drugs : the role of TNF-alpha mRNA downregulation in tumor cell sensitization .
8189599	0	TNF-alpha	130,139	TNF-alpha	11,20	TNF-alpha	TNF-alpha	7124	7124	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Overcoming TNF-alpha and drug resistance of human renal_cell_carcinoma cells by treatment with pentoxifylline in combination with TNF-alpha or drugs : the role of TNF-alpha mRNA downregulation in tumor cell sensitization .
8660797	0	TNF-alpha	92,101	TNF-alpha_receptor	38,56	TNF-alpha	TNF-alpha receptor	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Evidence for endogenous C1q modulates TNF-alpha_receptor synthesis and autocrine binding of TNF-alpha associated with lipid A activation of murine macrophages for nitric_oxide production .
16276011	0	TNF-alpha	0,9	TNF-beta	11,19	TNF-alpha	TNF-beta	7124	4049	Gene	Gene	polymorphisms|advmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , and IL-10 polymorphisms in patients with lung_cancer .
1697319	0	TNF-alpha	84,93	TNF-beta	112,120	TNF-alpha	TNF-beta	7124	4049	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	Highly sensitive enzyme immunoassays for antibodies to human tumor_necrosis_factor -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- .
1708843	0	TNF-alpha	44,53	TNF-beta	0,8	TNF-alpha	TNF-beta	7124	4049	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TNF-beta -LRB- lymphotoxin -RRB- strongly upregulates TNF-alpha gene expression in human peripheral blood lymphocytes .
17483704	0	TNF-alpha	0,9	TNF-beta	11,19	TNF-alpha	TNF-beta	7124	4049	Gene	Gene	PECAM-1|compound|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
2329277	0	TNF-alpha	37,46	TNF-beta	65,73	TNF-alpha	TNF-beta	21926(Tax:10090)	16992(Tax:10090)	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	Production of tumor_necrosis_factor -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- by murine pre-B and B cell lymphomas .
3490653	0	TNF-alpha	37,46	TNF-beta	65,73	TNF-alpha	TNF-beta	21926(Tax:10090)	16992(Tax:10090)	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	The genes for tumor_necrosis_factor -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- are tandemly arranged on chromosome 17 of the mouse .
7808952	1	TNF-alpha	110,119	TNF-beta	138,146	TNF-alpha	TNF-beta	7124	4049	Gene	Gene	cachectin|appos|START_ENTITY cachectin|appos|END_ENTITY	Effect of cachectin -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- on human erythropoiesis -RSB- .
22487520	0	TNF-alpha	0,9	TNFA	16,20	TNF-alpha	TNFA	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	TNF-alpha gene -LRB- TNFA -RRB- variants increase risk for multi-organ_dysfunction_syndrome -LRB- MODS -RRB- in acute pancreatitis .
18187611	0	TNF-alpha	0,9	TNFR1	19,24	TNF-alpha	TNFR1	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	TNF-alpha acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle .
20173391	0	TNF-alpha	0,9	TNFR2	37,42	TNF-alpha	TNFR2	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	START_ENTITY|dep|activator activator|nmod|cells cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
23487197	0	TNF-alpha	63,72	TNFa	74,78	TNF-alpha	TNFa	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of interleukin_2 -LRB- IL-2 -RRB- , interleukin_6 -LRB- IL-6 -RRB- , and TNF-alpha -LRB- TNFa -RRB- gene polymorphisms with paranoid schizophrenia in a Polish population .
20063037	0	TNF-alpha	0,9	TRAIL	72,77	TNF-alpha	TRAIL	7124	8743	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	TNF-alpha modulates the migratory response of mesenchymal stem cells to TRAIL .
12482669	0	TNF-alpha	71,80	Tat	38,41	TNF-alpha	Tat	7124	155871(Tax:11676)	Gene	Gene	induce|dobj|START_ENTITY triggered|xcomp|induce triggered|nmod|END_ENTITY	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha .
14708348	0	TNF-alpha	19,28	Tat	7,10	TNF-alpha	Tat	7124	155871(Tax:11676)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	-LSB- HIV-1 Tat induces TNF-alpha production by human monocytes : involvement of calcium and PKC pathways -RSB- .
23578838	0	TNF-alpha	60,69	Toll-like_receptor_3	94,114	TNF-alpha	Toll-like receptor 3	21926(Tax:10090)	142980(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
23947625	0	TNF-alpha	60,69	Toll-like_receptor_3	94,114	TNF-alpha	Toll-like receptor 3	21926(Tax:10090)	142980(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
16109884	0	TNF-alpha	12,21	Toll-like_receptor_4	45,65	TNF-alpha	Toll-like receptor 4	7124	7099	Gene	Gene	release|amod|START_ENTITY impairs|dobj|release impairs|nmod|stimulation stimulation|compound|END_ENTITY	HIV impairs TNF-alpha release in response to Toll-like_receptor_4 stimulation in human macrophages in vitro .
20018674	0	TNF-alpha	59,68	Toll-like_receptor_4	19,39	TNF-alpha	Toll-like receptor 4	21926(Tax:10090)	21898(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY pathway|nmod|antagonists pathway|compound|END_ENTITY	Involvement of the Toll-like_receptor_4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses .
26497121	0	TNF-alpha	74,83	Toll-like_receptor_4	139,159	TNF-alpha	Toll-like receptor 4	21926(Tax:10090)	21898(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY promote|dobj|secretion promote|nmod|cells cells|nmod|END_ENTITY	Clonorchis_sinensis excretory/secretory products promote the secretion of TNF-alpha in the mouse intrahepatic biliary epithelial cells via Toll-like_receptor_4 .
11570978	0	TNF-alpha	55,64	Tumor_Necrosis_Factor-alpha	26,53	TNF-alpha	Tumor Necrosis Factor-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The G-308A variant of the Tumor_Necrosis_Factor-alpha -LRB- TNF-alpha -RRB- gene is not associated with obesity , insulin resistance and body fat distribution .
12663241	0	TNF-alpha	133,142	Tumor_necrosis_factor_alpha	0,27	TNF-alpha	Tumor necrosis factor alpha	7124	7124	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
8359919	0	TNF-alpha	29,38	Tumor_necrosis_factor_alpha	0,27	TNF-alpha	Tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- production in mice immunized with Escherichia_coli : correlation with mortality after lethal challenge and production of a native inhibitor of TNF-alpha activity .
11277995	0	TNF-alpha	0,9	UCP-1	19,24	TNF-alpha	UCP-1	24835(Tax:10116)	24860(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs .
12044870	0	TNF-alpha	79,88	UCP-1	53,58	TNF-alpha	UCP-1	7124	7350	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Differential role of PPAR_gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes .
10233853	0	TNF-alpha	96,105	VCAM-1	29,35	TNF-alpha	VCAM-1	7124	7412	Gene	Gene	achieved|nmod|START_ENTITY achieved|nsubjpass|levels levels|nmod|END_ENTITY	Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability .
12883351	0	TNF-alpha	22,31	VCAM-1	60,66	TNF-alpha	VCAM-1	7124	7412	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Synergistic effect of TNF-alpha and either IL-4 or IL-13 on VCAM-1 expression by cultured human corneal fibroblasts .
16934424	0	TNF-alpha	0,9	VCAM-1	22,28	TNF-alpha	VCAM-1	7124	7412	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	TNF-alpha upregulates VCAM-1 and NF-kappaB in fibroblasts from nasal_polyps .
8879177	0	TNF-alpha	169,178	VCAM-1	131,137	TNF-alpha	VCAM-1	7124	7412	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|compound|END_ENTITY	Eosinophil infiltration in nonallergic chronic hyperplastic_sinusitis with nasal_polyposis -LRB- CHS/NP -RRB- is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha .
10403932	0	TNF-alpha	196,205	VEGF	133,137	TNF-alpha	VEGF	7124	7422	Gene	Gene	factor-alpha|appos|START_ENTITY vascular_endothelial_growth_factor|dep|factor-alpha vascular_endothelial_growth_factor|appos|END_ENTITY	Peripheral blood mononuclear cells from patients with rheumatoid_arthritis spontaneously secrete vascular_endothelial_growth_factor -LRB- VEGF -RRB- : specific up-regulation by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- in synovial fluid .
11860736	0	TNF-alpha	51,60	VEGF	0,4	TNF-alpha	VEGF	280943(Tax:9913)	281572(Tax:9913)	Gene	Gene	apoptosis|amod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	VEGF protects bovine aortic endothelial cells from TNF-alpha - and H2O2-induced apoptosis via co-modulatory effects on p38-and p42/p44-CCDPK signaling .
12551841	0	TNF-alpha	26,35	VEGF	11,15	TNF-alpha	VEGF	7124	7422	Gene	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|dobj|END_ENTITY	UV induces VEGF through a TNF-alpha independent pathway .
16040218	0	TNF-alpha	0,9	VEGF	49,53	TNF-alpha	VEGF	7124	7422	Gene	Gene	increase|nsubj|START_ENTITY increase|dobj|production production|amod|END_ENTITY	TNF-alpha and endotoxin increase hypoxia-induced VEGF production by cultured human nasal fibroblasts in synergistic fashion .
16438902	0	TNF-alpha	11,20	VEGF	55,59	TNF-alpha	VEGF	7124	7422	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells .
17096908	0	TNF-alpha	27,36	VEGF	58,62	TNF-alpha	VEGF	7124	7422	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of triptolide and TNF-alpha on the expression of VEGF in Raji cells and on angiogenesis in ECV304 cells -RSB- .
17725274	0	TNF-alpha	109,118	VEGF	79,83	TNF-alpha	VEGF	7124	7422	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|tumor_necrosis_factor vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
12876073	0	TNF-alpha	24,33	adiponectin	84,95	TNF-alpha	adiponectin	7124	9370	Gene	Gene	expression|nmod|START_ENTITY expression|dep|implications implications|nmod|expression expression|compound|END_ENTITY	Increased expression of TNF-alpha , IL-6 , and IL-8 in HALS : implications for reduced adiponectin expression and plasma levels .
15629137	0	TNF-alpha	84,93	adiponectin	58,69	TNF-alpha	adiponectin	7124	9370	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|suppression suppression|nmod|expression expression|compound|END_ENTITY	c-Jun_N-terminal_kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes .
17537727	0	TNF-alpha	101,110	adiponectin	50,61	TNF-alpha	adiponectin	7124	9370	Gene	Gene	expression|appos|START_ENTITY increases|dobj|expression increases|nsubj|treatment treatment|nmod|macrophages macrophages|nmod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
17537727	0	TNF-alpha	175,184	adiponectin	50,61	TNF-alpha	adiponectin	7124	9370	Gene	Gene	role|nmod|START_ENTITY activation|dep|role expression|nmod|activation increases|dobj|expression increases|nsubj|treatment treatment|nmod|macrophages macrophages|nmod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
18577375	0	TNF-alpha	57,66	adiponectin	94,105	TNF-alpha	adiponectin	7124	9370	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|expression expression|compound|END_ENTITY	6-Shogaol and 6-gingerol , the pungent of ginger , inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes .
25888509	0	TNF-alpha	0,9	adiponectin	96,107	TNF-alpha	adiponectin	21926(Tax:10090)	11450(Tax:10090)	Gene	Gene	antagonism|amod|START_ENTITY ameliorates|nsubj|antagonism ameliorates|advcl|upregulating upregulating|dobj|END_ENTITY	TNF-alpha antagonism ameliorates myocardial_ischemia / reperfusion injury in mice by upregulating adiponectin .
25888509	0	TNF-alpha	0,9	adiponectin	96,107	TNF-alpha	adiponectin	21926(Tax:10090)	11450(Tax:10090)	Gene	Gene	antagonism|amod|START_ENTITY ameliorates|nsubj|antagonism ameliorates|advcl|upregulating upregulating|dobj|END_ENTITY	TNF-alpha antagonism ameliorates myocardial_ischemia / reperfusion injury in mice by upregulating adiponectin .
26407855	0	TNF-alpha	66,75	adiponectin	37,48	TNF-alpha	adiponectin	7124	9370	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|multimerization multimerization|nmod|END_ENTITY	The multimerization and secretion of adiponectin are regulated by TNF-alpha .
17478756	0	TNF-alpha	0,9	alpha1	42,48	TNF-alpha	alpha1	7124	146	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	TNF-alpha suppresses prolyl-4-hydroxylase alpha1 expression via the ASK1-JNK-NonO pathway .
15694363	0	TNF-alpha	0,9	angiopoietin-1	20,34	TNF-alpha	angiopoietin-1	7124	284	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	TNF-alpha modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-kappa_B signalling pathway .
24038215	0	TNF-alpha	47,56	apolipoprotein_A-I	14,32	TNF-alpha	apolipoprotein A-I	7124	335	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of apolipoprotein_A-I expression by TNF-alpha in HepG2 cells : requirement for c-jun .
20619088	0	TNF-alpha	20,29	beta-1	38,44	TNF-alpha	beta-1	7124	3779	Gene	Gene	START_ENTITY|acl|induced induced|xcomp|END_ENTITY	-LSB- The role of PKC to TNF-alpha induced beta-1 , 4-galactosyltransferase-I expression in endothelial cells -RSB- .
15385257	0	TNF-alpha	143,152	beta1_integrin	102,116	TNF-alpha	beta1 integrin	7124	3688	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Cardiac surgery with extracorporeal circulation : neutrophil transendothelial migration is mediated by beta1_integrin -LRB- CD29 -RRB- in the presence of TNF-alpha .
12397613	0	TNF-alpha	0,9	bone_sialoprotein	21,38	TNF-alpha	bone sialoprotein	24835(Tax:10116)	24477(Tax:10116)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	TNF-alpha suppresses bone_sialoprotein -LRB- BSP -RRB- expression in ROS17/2 .8 cells .
15629137	0	TNF-alpha	84,93	c-Jun_N-terminal_kinase	0,23	TNF-alpha	c-Jun N-terminal kinase	7124	5599	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	c-Jun_N-terminal_kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes .
7957110	0	TNF-alpha	65,74	c-Myc	0,5	TNF-alpha	c-Myc	7124	4609	Gene	Gene	action|nmod|START_ENTITY induces|nmod|action induces|nsubj|END_ENTITY	c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha .
7640345	0	TNF-alpha	80,89	cA2	44,47	TNF-alpha	cA2	7124	760	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions .
9366515	0	TNF-alpha	26,35	calcitonin_gene-related_peptide	50,81	TNF-alpha	calcitonin gene-related peptide	21926(Tax:10090)	12310(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Inhibition of LPS-induced TNF-alpha production by calcitonin_gene-related_peptide -LRB- CGRP -RRB- in cultured mouse peritoneal macrophages .
9417811	0	TNF-alpha	58,67	calcitonin_gene-related_peptide	17,48	TNF-alpha	calcitonin gene-related peptide	24835(Tax:10116)	24241(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The neuropeptide calcitonin_gene-related_peptide inhibits TNF-alpha but poorly induces IL-6 production by fetal rat osteoblasts .
11414450	0	TNF-alpha	0,9	caspase_3	18,27	TNF-alpha	caspase 3	7124	836	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TNF-alpha induces caspase_3 -LRB- CPP_32 -RRB- dependent apoptosis in human cholangiocarcinoma cell line .
18341691	0	TNF-alpha	71,80	cd38	18,22	TNF-alpha	cd38	7124	952	Gene	Gene	smooth|nmod|START_ENTITY smooth|nsubj|Regulation Regulation|nmod|promoter promoter|amod|END_ENTITY	Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone .
12538692	0	TNF-alpha	0,9	connexin43	32,42	TNF-alpha	connexin43	7124	2697	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses .
24385694	0	TNF-alpha	44,53	cytotoxic_T-lymphocyte_antigen-4	10,42	TNF-alpha	cytotoxic T-lymphocyte antigen-4	7124	1493	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Effect of cytotoxic_T-lymphocyte_antigen-4 , TNF-alpha polymorphisms on osteosarcoma : evidences from a meta-analysis .
16981010	0	TNF-alpha	0,9	eNOS	24,28	TNF-alpha	eNOS	21926(Tax:10090)	18127(Tax:10090)	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents .
1566813	0	TNF-alpha	55,64	endothelin-1	34,46	TNF-alpha	endothelin-1	280943(Tax:9913)	281137(Tax:9913)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the endothelin-1 gene by TNF-alpha .
16232886	0	TNF-alpha	49,58	gadd_153	94,102	TNF-alpha	gadd 153	7124	1649	Gene	Gene	gene|amod|START_ENTITY effect|nmod|gene effect|nmod|END_ENTITY	Bystander-killing effect and cyclic induction of TNF-alpha gene under heat-inducible promoter gadd_153 .
16233154	0	TNF-alpha	20,29	gadd_153	78,86	TNF-alpha	gadd 153	7124	1649	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Radiation-inducible TNF-alpha gene expression under stress-inducible promoter gadd_153 for cancer therapy .
1375304	0	TNF-alpha	18,27	granulocyte_colony-stimulating_factor	56,93	TNF-alpha	granulocyte colony-stimulating factor	7124	1440	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Recombinant human TNF-alpha stimulates the secretion of granulocyte_colony-stimulating_factor in vivo .
9013974	0	TNF-alpha	39,48	growth_hormone	21,35	TNF-alpha	growth hormone	7124	2688	Gene	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of growth_hormone on TNF-alpha secretion and nuclear factor-kappaB translocation in lipopolysaccharide-stimulated human monocytes .
11034403	0	TNF-alpha	56,65	heat-shock_protein_27	79,100	TNF-alpha	heat-shock protein 27	7124	3315	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock_protein_27 -LRB- Hsp27 -RRB- suggests Hsp27 is primarily an antiinflammatory stimulus .
10330231	0	TNF-alpha	0,9	heme_oxygenase-1	31,47	TNF-alpha	heme oxygenase-1	7124	3162	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	TNF-alpha and IL-1alpha induce heme_oxygenase-1 via protein_kinase_C , Ca2 + , and phospholipase_A2 in endothelial cells .
19099662	0	TNF-alpha	57,66	hemoglobin	16,26	TNF-alpha	hemoglobin	397086(Tax:9823)	100323610(Tax:9823)	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of free hemoglobin on hemorrhagic_shock in pigs : TNF-alpha , IL-6 expressions in serum and rates of MODS after the blood transfusion -RSB- .
17069861	0	TNF-alpha	0,9	hsp_27	20,26	TNF-alpha	hsp 27	7124	3315	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	TNF-alpha decreases hsp_27 in human blood mononuclear cells : involvement of protein kinase c. Treatment of PBMCs with TNF-alpha decreased the levels of heat_shock protein -LRB- HSP -RRB- 27 , but had little effect on the level of HSP70 .
19802525	0	TNF-alpha	0,9	iNOS	20,24	TNF-alpha	iNOS	24835(Tax:10116)	24599(Tax:10116)	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis .
9168934	0	TNF-alpha	0,9	inducible_nitric_oxide_synthase	19,50	TNF-alpha	inducible nitric oxide synthase	7124	4843	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	TNF-alpha mediates inducible_nitric_oxide_synthase expression in human neuroblastoma cell line by cisplatin .
15146098	0	TNF-alpha	12,21	insulin	25,32	TNF-alpha	insulin	7124	3630	Gene	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	The role of TNF-alpha in insulin resistance .
12420742	0	TNF-alpha	102,111	intercellular_adhesion_molecule-1	57,90	TNF-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Monochloramine inhibits the expression of E-selectin and intercellular_adhesion_molecule-1 induced by TNF-alpha through the suppression of NF-kappaB activation in human endothelial cells .
17607964	0	TNF-alpha	258,267	intercellular_adhesion_molecule-1	42,75	TNF-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	-RSB-|appos|START_ENTITY induced|nmod|-RSB- induced|csubj|-LSB- -LSB-|nmod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
8973625	0	TNF-alpha	190,199	intercellular_adhesion_molecule-1	69,102	TNF-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|amod|END_ENTITY	Expression of leucocyte-endothelial adhesion molecules is limited to intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the lung of pneumoconiotic patients : role of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- .
17693933	0	TNF-alpha	125,134	intercellular_adhesion_molecule_1	73,106	TNF-alpha	intercellular adhesion molecule 1	7124	3383	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of adenosine_A2A_receptor inhibits LPS-induced expression of intercellular_adhesion_molecule_1 and production of TNF-alpha in human peripheral blood mononuclear cells .
12563732	0	TNF-alpha	97,106	interferon-gamma	66,82	TNF-alpha	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY induced|advcl|-RSB- induced|nmod|END_ENTITY	-LSB- Anti-Toxoplasma effect of activated mouse macrophages induced by interferon-gamma combined with TNF-alpha -RSB- .
1532988	0	TNF-alpha	79,88	interferon-gamma	158,174	TNF-alpha	interferon-gamma	7124	3458	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Different molecular mechanisms lead to same endpoints with different function : TNF-alpha induces non-functional CSF-1 receptors on HL-60 cells in contrast to interferon-gamma .
15806975	0	TNF-alpha	109,118	interferon-gamma	50,66	TNF-alpha	interferon-gamma	7124	3458	Gene	Gene	tumor_necrosis_factor-alpha|appos|START_ENTITY END_ENTITY|appos|tumor_necrosis_factor-alpha	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
18208824	0	TNF-alpha	110,119	interferon-gamma	165,181	TNF-alpha	interferon-gamma	7124	3458	Gene	Gene	START_ENTITY|acl|blocking blocking|advcl|using using|dobj|release release|amod|END_ENTITY	Evaluation of latent_tuberculosis_infection in patients with inflammatory arthropathies before treatment with TNF-alpha blocking drugs using a novel flow-cytometric interferon-gamma release assay .
8038591	0	TNF-alpha	76,85	interferon-gamma	88,104	TNF-alpha	interferon-gamma	7124	3458	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	Isolated perfusion of the limb with high-dose tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , interferon-gamma -LRB- IFN-gamma -RRB- and melphalan for melanoma stage III .
9472684	0	TNF-alpha	83,92	interferon-gamma	101,117	TNF-alpha	interferon-gamma	7124	3458	Gene	Gene	and/or|appos|START_ENTITY Apoptosis|nmod|and/or Apoptosis|amod|END_ENTITY	Apoptosis of colorectal_adenocarcinoma -LRB- COLO 201 -RRB- by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and/or interferon-gamma -LRB- IFN-gamma -RRB- , resulting from down-modulation of Bcl-2 expression .
18802049	0	TNF-alpha	18,27	interferon_regulatory_factors_1_and_8	55,92	TNF-alpha	interferon regulatory factors 1 and 8	21926(Tax:10090)	16362;15900	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	IFN-gamma-induced TNF-alpha expression is regulated by interferon_regulatory_factors_1_and_8 in mouse macrophages .
12622883	0	TNF-alpha	10,19	interleukin-1_beta_converting_enzyme	81,117	TNF-alpha	interleukin-1 beta converting enzyme	21926(Tax:10090)	12362(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of TNF-alpha on the induction of apoptosis in murine macrophages : role of interleukin-1_beta_converting_enzyme .
12445803	0	TNF-alpha	78,87	interleukin-6	89,102	TNF-alpha	interleukin-6	7124	3569	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|amod|END_ENTITY	Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- interleukin-6 -LRB- IL-6 -RRB- and soluble interleukin-6_receptor -LRB- sIL-6R gp80 -RRB- in multiple_sclerosis patients .
15652492	0	TNF-alpha	0,9	interleukin-8	18,31	TNF-alpha	interleukin-8	7124	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	TNF-alpha induces interleukin-8 and endothelin-1 expression in human endothelial cells with different redox pathways .
17725274	0	TNF-alpha	109,118	interleukin_6	121,134	TNF-alpha	interleukin 6	7124	3569	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|tumor_necrosis_factor vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
15082348	0	TNF-alpha	101,110	lipopolysaccharide-binding_protein	7,41	TNF-alpha	lipopolysaccharide-binding protein	24835(Tax:10116)	29469(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Tissue lipopolysaccharide-binding_protein expression in rats after thermal injury : potential role of TNF-alpha .
10415052	0	TNF-alpha	28,37	lymphotoxin-alpha	38,55	TNF-alpha	lymphotoxin-alpha	21926(Tax:10090)	16992(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic_candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida_albicans .
11532377	0	TNF-alpha	49,58	macrophage_inflammatory_protein_3alpha	83,121	TNF-alpha	macrophage inflammatory protein 3alpha	7124	6364	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Differentiated keratinocytes are responsible for TNF-alpha regulated production of macrophage_inflammatory_protein_3alpha / CCL20 , a potent chemokine for Langerhans cells .
12878172	0	TNF-alpha	60,69	matrix_metalloproteinase-13	13,40	TNF-alpha	matrix metalloproteinase-13	7124	4322	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of matrix_metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases , AP-1 , and NF-kappaB transcription factors in articular chondrocytes .
11073115	0	TNF-alpha	18,27	matrix_metalloproteinase-9	48,74	TNF-alpha	matrix metalloproteinase-9	7124	4318	Gene	Gene	stimulates|amod|START_ENTITY monocyte|nsubj|stimulates monocyte|dobj|expression expression|amod|END_ENTITY	Fibronectin-bound TNF-alpha stimulates monocyte matrix_metalloproteinase-9 expression and regulates chemotaxis .
16720051	0	TNF-alpha	113,122	matrix_metalloproteinase-9	83,109	TNF-alpha	matrix metalloproteinase-9	7124	4318	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|stimulation stimulation|nmod|END_ENTITY	Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix_metalloproteinase-9 by TNF-alpha in human monocytes .
17276429	0	TNF-alpha	82,91	matrix_metalloproteinase-9	36,62	TNF-alpha	matrix metalloproteinase-9	7124	4318	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Phosphatidic_acid as a regulator of matrix_metalloproteinase-9 expression via the TNF-alpha signaling pathway .
17357478	0	TNF-alpha	0,9	matrix_metalloproteinase-9	23,49	TNF-alpha	matrix metalloproteinase-9	7124	4318	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	TNF-alpha up-regulates matrix_metalloproteinase-9 expression and activity in alveolar macrophages from patients with chronic_obstructive_pulmonary_disease .
18496150	0	TNF-alpha	0,9	matrix_metalloproteinase-9	17,43	TNF-alpha	matrix metalloproteinase-9	7124	4318	Gene	Gene	drives|amod|START_ENTITY drives|amod|END_ENTITY	TNF-alpha drives matrix_metalloproteinase-9 in squamous oral_carcinogenesis .
21502320	0	TNF-alpha	83,92	matrix_metalloproteinase-9	107,133	TNF-alpha	matrix metalloproteinase-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
15136050	0	TNF-alpha	84,93	monocyte_chemoattractant_protein-1	17,51	TNF-alpha	monocyte chemoattractant protein-1	7124	6347	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Aspirin inhibits monocyte_chemoattractant_protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells .
10728932	0	TNF-alpha	11,20	mucin	38,43	TNF-alpha	mucin	7124	100508689	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of TNF-alpha and IL-1_beta on mucin , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells .
11052828	0	TNF-alpha	0,9	mucin	82,87	TNF-alpha	mucin	7124	100508689	Gene	Gene	START_ENTITY|dep|aspects aspects|nmod|hypersecretion hypersecretion|compound|END_ENTITY	TNF-alpha in the regulation of MUC5AC secretion : some aspects of cytokine-induced mucin hypersecretion on the in vitro model .
11044363	0	TNF-alpha	163,172	nuclear_factor-kappaB	35,56	TNF-alpha	nuclear factor-kappaB	7124	4790	Gene	Gene	death|amod|START_ENTITY END_ENTITY|nmod|death	Inhibition of transcription factor nuclear_factor-kappaB by a mutant inhibitor-kappaBalpha attenuates resistance of human head_and_neck_squamous_cell_carcinoma to TNF-alpha caspase-mediated cell death .
11978627	0	TNF-alpha	169,178	nuclear_factor-kappaB	133,154	TNF-alpha	nuclear factor-kappaB	7124	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Tumor_necrosis_factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes : nuclear_factor-kappaB activation by TNF-alpha is obligatory .
12213594	0	TNF-alpha	42,51	nuclear_factor-kappaB	61,82	TNF-alpha	nuclear factor-kappaB	7124	4790	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Reduction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- related nuclear_factor-kappaB -LRB- NF-kappaB -RRB- translocation but not inhibitor kappa-B -LRB- Ikappa-B -RRB- - degradation by Rho protein inhibition in human endothelial cells .
11097743	0	TNF-alpha	0,9	p21	18,21	TNF-alpha	p21	7124	1026	Gene	Gene	START_ENTITY|acl|induced induced|dobj|END_ENTITY	TNF-alpha induced p21 -LRB- WAF1 -RRB- but not Bax in colon_cancer cells WiDr with mutated p53 : important role of protein stabilization .
10210635	0	TNF-alpha	30,39	p38	0,3	TNF-alpha	p38	7124	1432	Gene	Gene	production|amod|START_ENTITY decreases|dobj|production decreases|nsubj|inhibition inhibition|amod|END_ENTITY	p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function .
10521481	0	TNF-alpha	120,129	p38	73,76	TNF-alpha	p38	7124	1432	Gene	Gene	expression|amod|START_ENTITY protein|dep|expression protein|amod|END_ENTITY	Engagement of tumor necrosis factor -LRB- TNF -RRB- receptor 1 leads to ATF-2 - and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression .
10620700	0	TNF-alpha	86,95	p38	12,15	TNF-alpha	p38	7124	1432	Gene	Gene	fibroblasts|amod|START_ENTITY production|nmod|fibroblasts kinase|nmod|production kinase|nsubj|role role|nmod|protein protein|amod|END_ENTITY	The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha - or IL-1beta-stimulated rheumatoid synovial fibroblasts .
10836611	0	TNF-alpha	0,9	p38	84,87	TNF-alpha	p38	7124	1432	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|pathway pathway|amod|END_ENTITY	TNF-alpha and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway .
10880231	0	TNF-alpha	25,34	p38	0,3	TNF-alpha	p38	7124	1432	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|kinase kinase|amod|END_ENTITY	p38 map kinase regulates TNF-alpha production in human astrocytes and microglia by multiple mechanisms .
11715476	0	TNF-alpha	54,63	p38	27,30	TNF-alpha	p38	7124	1432	Gene	Gene	-RSB-|amod|START_ENTITY LPS|nmod|-RSB- induced|nmod|LPS induced|csubj|-LSB- -LSB-|dobj|role role|nmod|activation activation|nmod|MAPK MAPK|amod|END_ENTITY	-LSB- The role of activation of p38 MAPK induced by LPS in TNF-alpha gene expression -RSB- .
11994432	0	TNF-alpha	55,64	p38	112,115	TNF-alpha	p38	7124	1432	Gene	Gene	production|amod|START_ENTITY suppression|nmod|production mechanism|nmod|suppression mechanism|acl:relcl|involve involve|dobj|inhibition inhibition|nmod|protein protein|amod|END_ENTITY	Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa_B in primary human macrophages .
11994493	0	TNF-alpha	64,73	p38	0,3	TNF-alpha	p38	7124	5594	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|kinase kinase|nummod|END_ENTITY	p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory_bowel_disease .
12096921	0	TNF-alpha	79,88	p38	15,18	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY pathways|nmod|production pathways|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells .
12142907	0	TNF-alpha	33,42	p38	0,3	TNF-alpha	p38	7124	1432	Gene	Gene	Expression|compound|START_ENTITY Necessary|nmod|Expression Necessary|nsubj|Signal Signal|compound|END_ENTITY	p38 MAPK Signal is Necessary for TNF-alpha Gene Expression in RAW Cells .
12297009	0	TNF-alpha	69,78	p38	8,11	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY signaling|dep|induced apoptosis|acl|signaling regulation|nmod|apoptosis MAPK|nmod|regulation MAPK|nsubj|Role Role|nmod|END_ENTITY	Role of p38 MAPK in the regulation of apoptosis signaling induced by TNF-alpha in differentiated PC12 cells .
12297293	0	TNF-alpha	73,82	p38	0,3	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|MAPK MAPK|compound|END_ENTITY	p38 MAPK mediates the regulation of alpha1 -LRB- I -RRB- procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells -LRB- 1 -RRB- .
14644621	0	TNF-alpha	106,115	p38	50,53	TNF-alpha	p38	21926(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY upregulation|nmod|expression kinase|nmod|upregulation kinase|nsubj|roles roles|nmod|protein protein|amod|END_ENTITY	Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol -LRB- vomitoxin -RRB- .
14656985	0	TNF-alpha	30,39	p38	100,103	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	overexpressing|dobj|START_ENTITY Cardiomyocytes|acl|overexpressing attract|nsubj|Cardiomyocytes attract|dobj|migration migration|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	Cardiomyocytes overexpressing TNF-alpha attract migration of embryonic stem cells via activation of p38 and c-Jun_amino-terminal_kinase .
15365619	0	TNF-alpha	93,102	p38	116,119	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Rosiglitazone ameliorates insulin resistance in brown_adipocytes of Wistar_rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases .
15557189	0	TNF-alpha	22,31	p38	46,49	TNF-alpha	p38	7124	1432	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|MAPK MAPK|amod|END_ENTITY	A novel mechanism for TNF-alpha regulation by p38 MAPK : involvement of NF-kappa_B with implications for therapy in rheumatoid_arthritis .
15603917	0	TNF-alpha	19,28	p38	66,69	TNF-alpha	p38	7124	1432	Gene	Gene	expression|nsubj|START_ENTITY expression|nmod|MAPK MAPK|amod|END_ENTITY	Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway .
15979653	0	TNF-alpha	16,25	p38	41,44	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells .
16813528	0	TNF-alpha	0,9	p38	19,22	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats .
16819191	0	TNF-alpha	112,121	p38	151,154	TNF-alpha	p38	7124	5594	Gene	Gene	stimulated|nmod|START_ENTITY HT29|acl|stimulated binding|nmod|HT29 decreases|xcomp|binding decreases|dobj|suppression suppression|nmod|END_ENTITY	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta : suppression of p38 , JNK and NF-kappaB_p65 as potential targets .
16935932	0	TNF-alpha	14,23	p38	82,85	TNF-alpha	p38	7124	1432	Gene	Gene	destabilization|amod|START_ENTITY mediated|nsubjpass|destabilization mediated|nmod|suppression suppression|nmod|activation activation|amod|END_ENTITY	IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression .
16949835	0	TNF-alpha	55,64	p38	9,12	TNF-alpha	p38	7124	1432	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells kinases|nmod|expression kinases|nsubj|Roles Roles|nmod|END_ENTITY	Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha - and dexamethasone-stimulated human periodontal ligament cells .
17906102	0	TNF-alpha	46,55	p38	0,3	TNF-alpha	p38	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	interplay|nmod|START_ENTITY mediate|dobj|interplay mediate|nsubj|END_ENTITY	p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac_myocyte_apoptosis .
19797215	0	TNF-alpha	62,71	p38	81,84	TNF-alpha	p38	280943(Tax:9913)	534492(Tax:9913)	Gene	Gene	response|nmod|START_ENTITY endothelium|nmod|response dysfunction|nmod|endothelium dysfunction|dep|role role|nmod|kinase kinase|amod|END_ENTITY	Barrier dysfunction of the corneal endothelium in response to TNF-alpha : role of p38 MAP kinase .
9120304	0	TNF-alpha	171,180	p38	47,50	TNF-alpha	p38	21926(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY p42MAPK|nmod|synthesis role|nmod|p42MAPK activates|parataxis|role activates|dobj|END_ENTITY	Fc gamma receptor cross-linking activates p42 , p38 , and JNK/SAPK mitogen-activated protein kinases in murine macrophages : role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis .
9469462	0	TNF-alpha	103,112	p38	0,3	TNF-alpha	p38	7124	1432	Gene	Gene	stimulation|compound|START_ENTITY triggered|nmod|stimulation function|acl|triggered required|nmod|function required|nsubjpass|activation activation|amod|END_ENTITY	p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation .
14553829	0	TNF-alpha	44,53	p38_MAPK	14,22	TNF-alpha	p38 MAPK	21926(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY decreases|dobj|expression decreases|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of p38_MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia .
15746179	0	TNF-alpha	0,9	p38_MAPK	19,27	TNF-alpha	p38 MAPK	21926(Tax:10090)	26416(Tax:10090)	Gene	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	TNF-alpha acts via p38_MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle .
17151142	0	TNF-alpha	0,9	p38_MAPK	69,77	TNF-alpha	p38 MAPK	21926(Tax:10090)	26416(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TNF-alpha regulates myogenesis and muscle regeneration by activating p38_MAPK .
20499049	0	TNF-alpha	14,23	p38_MAPK	142,150	TNF-alpha	p38 MAPK	7124	1432	Gene	Gene	Expression|nmod|START_ENTITY attenuated|nsubjpass|Expression attenuated|advcl|blocking blocking|dobj|END_ENTITY	Expression of TNF-alpha and IL-6 in HMC-1 cells treated with bisphenol_A is attenuated by plant-originating glycoprotein -LRB- 75 kDa -RRB- by blocking p38_MAPK .
11238627	0	TNF-alpha	145,154	p38_mitogen-activated_protein_kinase	20,56	TNF-alpha	p38 mitogen-activated protein kinase	7124	1432	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	A critical role for p38_mitogen-activated_protein_kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide , TNF-alpha , and contact sensitizers .
9379049	0	TNF-alpha	41,50	p38mapk	14,21	TNF-alpha	p38mapk	21926(Tax:10090)	26416(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of p38mapk , MKK3 , and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages .
9120304	0	TNF-alpha	171,180	p42MAPK	131,138	TNF-alpha	p42MAPK	21926(Tax:10090)	26413(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Fc gamma receptor cross-linking activates p42 , p38 , and JNK/SAPK mitogen-activated protein kinases in murine macrophages : role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis .
10080877	0	TNF-alpha	111,120	p55	144,147	TNF-alpha	p55	7124	7132	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|receptor receptor|amod|END_ENTITY	Identification of TNF-alpha binding peptides from a D-amino_acid_hexapeptide library that specifically inhibit TNF-alpha binding to recombinant p55 receptor .
10080877	0	TNF-alpha	18,27	p55	144,147	TNF-alpha	p55	7124	7132	Gene	Gene	binding|compound|START_ENTITY Identification|nmod|binding peptides|nsubj|Identification peptides|nmod|library library|acl:relcl|inhibit inhibit|xcomp|binding binding|nmod|receptor receptor|amod|END_ENTITY	Identification of TNF-alpha binding peptides from a D-amino_acid_hexapeptide library that specifically inhibit TNF-alpha binding to recombinant p55 receptor .
10385602	0	TNF-alpha	90,99	p55	46,49	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY downregulate|dobj|activity downregulate|nsubj|receptors receptors|amod|p75 p75|dep|END_ENTITY	Soluble tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 and interleukin-10 downregulate TNF-alpha activity during the lung response to silica particles in NMRI mice .
10623807	0	TNF-alpha	8,17	p55	4,7	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity .
11137581	0	TNF-alpha	30,39	p55	23,26	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Selective role for the p55 Kd TNF-alpha receptor in immune unresponsiveness induced by an acute viral encephalitis .
11175323	0	TNF-alpha	22,31	p55	15,18	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Absence of the p55 Kd TNF-alpha receptor promotes survival in rabies_virus acute encephalitis .
14593216	0	TNF-alpha	48,57	p55	16,19	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	transport|amod|START_ENTITY mediating|dobj|transport Upregulation|acl|mediating Upregulation|nmod|receptors receptors|amod|END_ENTITY	Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier .
15514106	0	TNF-alpha	96,105	p55	92,95	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Signaling for myocardial_depression in hemorrhagic_shock : roles of Toll-like_receptor_4 and p55 TNF-alpha receptor .
16495559	0	TNF-alpha	37,46	p55	170,173	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY Role|nmod|tumor_necrosis_factor_alpha Role|dep|resistance resistance|nmod|END_ENTITY	Role of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis : increased resistance of TNF receptor p55 - and p75-deficient mice to fatal ehrlichial_infection .
7520777	0	TNF-alpha	29,38	p55	224,227	TNF-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	production|appos|START_ENTITY production|dep|role role|nmod|receptors receptors|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem_cell_factor and interleukin-7 : novel stimulatory role of p55 TNF receptors .
7535144	0	TNF-alpha	0,9	p55	39,42	TNF-alpha	p55	7124	7132	Gene	Gene	START_ENTITY|dep|role role|nmod|receptors receptors|amod|END_ENTITY	TNF-alpha , the great imitator : role of p55 and p75 TNF receptors in hematopoiesis .
15980040	0	TNF-alpha	51,60	p65	124,127	TNF-alpha	p65	7124	5970	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nmod|modulation modulation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation .
10385602	0	TNF-alpha	90,99	p75	54,57	TNF-alpha	p75	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY downregulate|dobj|activity downregulate|nsubj|receptors receptors|amod|END_ENTITY	Soluble tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 and interleukin-10 downregulate TNF-alpha activity during the lung response to silica particles in NMRI mice .
12370348	0	TNF-alpha	24,33	p75	20,23	TNF-alpha	p75	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway_hyperresponsiveness by gamma delta T cells .
12598326	0	TNF-alpha	32,41	p75	28,31	TNF-alpha	p75	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen_activator_inhibitor-1 .
18928394	0	TNF-alpha	34,43	p75	44,47	TNF-alpha	p75	7124	7133	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Early evolution of plasma soluble TNF-alpha p75 receptor as a marker of progression in treated HIV-infected patients .
8974008	0	TNF-alpha	124,133	p75	66,69	TNF-alpha	p75	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	p55|nmod|START_ENTITY END_ENTITY|nmod|p55	In vitro comparison of inhibiting ability of soluble TNF receptor p75 -LRB- TBP_II -RRB- vs. soluble TNF receptor p55 -LRB- TBP_I -RRB- against TNF-alpha and TNF-beta .
11137138	0	TNF-alpha	84,93	phospholipase_A2	24,40	TNF-alpha	phospholipase A2	7124	151056	Gene	Gene	level|nsubj|START_ENTITY level|nmod|effect effect|nmod|END_ENTITY	In vivo effect of snake phospholipase_A2 -LRB- crotoxin + cardiotoxin -RRB- on serum IL-1alpha , TNF-alpha and IL-1ra level in humans .
16564042	0	TNF-alpha	53,62	phospholipase_A2	10,26	TNF-alpha	phospholipase A2	21926(Tax:10090)	18780(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Secretory phospholipase_A2 induces apoptosis through TNF-alpha and cytochrome c-mediated caspase cascade in murine macrophage RAW 264.7 cells .
9873818	0	TNF-alpha	39,48	phospholipase_D	11,26	TNF-alpha	phospholipase D	7124	2822	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Changes of phospholipase_D activity in TNF-alpha and anti-Fas/Apo1 monoclonal antibody induced apoptosis in HL-60 and A20 cells .
10208482	0	TNF-alpha	84,93	plasminogen_activator_inhibitor-1	14,47	TNF-alpha	plasminogen activator inhibitor-1	7124	5054	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|tissue tissue|amod|END_ENTITY	Expression of plasminogen_activator_inhibitor-1 in human adipose tissue : a role for TNF-alpha ?
10362602	0	TNF-alpha	0,9	plasminogen_activator_inhibitor-1	57,90	TNF-alpha	plasminogen activator inhibitor-1	7124	5054	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	TNF-alpha and insulin , alone and synergistically , induce plasminogen_activator_inhibitor-1 expression in adipocytes .
12527424	0	TNF-alpha	91,100	plasminogen_activator_inhibitor-1	27,60	TNF-alpha	plasminogen activator inhibitor-1	21926(Tax:10090)	18787(Tax:10090)	Gene	Gene	converting|amod|START_ENTITY converting|amod|END_ENTITY	Differential expression of plasminogen_activator_inhibitor-1 , tumor_necrosis_factor-alpha , TNF-alpha converting enzyme and ADAMTS family members in murine fat territories .
15677734	0	TNF-alpha	0,9	plasminogen_activator_inhibitor-1	36,69	TNF-alpha	plasminogen activator inhibitor-1	7124	5054	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	TNF-alpha , but not IL-6 , stimulates plasminogen_activator_inhibitor-1 expression in human subcutaneous adipose tissue .
1802676	0	TNF-alpha	10,19	prolactin	23,32	TNF-alpha	prolactin	24835(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of TNF-alpha on prolactin secretion from rat anterior pituitary and dopamine release from the hypothalamus : comparison with the effect of interleukin-1_beta .
12067299	0	TNF-alpha	45,54	proteinase_3	6,18	TNF-alpha	proteinase 3	7124	5657	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Human proteinase_3 can inhibits LPS-mediated TNF-alpha production through CD14 degradation : lack of influence of antineutrophil cytoplasmic antibodies .
11242177	0	TNF-alpha	32,41	rTBP-1	59,65	TNF-alpha	rTBP-1	7124	29677(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	In vitro effects of recombinant TNF-alpha binding protein -LRB- rTBP-1 -RRB- on hematopoiesis of HIV-infected patients .
16602627	0	TNF-alpha	112,121	regulated_upon_activation_normal_T_cell_expressed_and_secreted	34,96	TNF-alpha	regulated upon activation normal T cell expressed and secreted	24835(Tax:10116)	81780(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Rat peritoneal mast cells release regulated_upon_activation_normal_T_cell_expressed_and_secreted -LRB- RANTES -RRB- after TNF-alpha activation .
18561328	0	TNF-alpha	119,128	reticulocalbin_1	28,44	TNF-alpha	reticulocalbin 1	7124	5954	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Novel surface expression of reticulocalbin_1 on bone endothelial cells and human prostate_cancer cells is regulated by TNF-alpha .
18561328	0	TNF-alpha	119,128	reticulocalbin_1	28,44	TNF-alpha	reticulocalbin 1	7124	5954	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Novel surface expression of reticulocalbin_1 on bone endothelial cells and human prostate_cancer cells is regulated by TNF-alpha .
19576750	0	TNF-alpha	176,185	scavenger_receptor_B1	140,161	TNF-alpha	scavenger receptor B1	7124	949	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK , JAK/STAT , AP-1 and IRF-1 , and depends on up-regulation of scavenger_receptor_B1 expression in TNF-alpha - and IFN-gamma-stimulated C6 glioma cells .
9758897	0	TNF-alpha	30,39	substance_P	43,54	TNF-alpha	substance P	7124	6863	Gene	Gene	produce|dobj|START_ENTITY produce|nmod|END_ENTITY	Human skin mast cells produce TNF-alpha by substance_P .
17312125	0	TNF-alpha	75,84	suppressor_of_cytokine_signaling_3	14,48	TNF-alpha	suppressor of cytokine signaling 3	7124	9021	Gene	Gene	stability|nmod|START_ENTITY stability|amod|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade .
15733976	0	TNF-alpha	11,20	thrombomodulin	55,69	TNF-alpha	thrombomodulin	7124	7056	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial_protein_C_receptor in human endothelial cells .
15469694	0	TNF-alpha	72,81	tissue_transglutaminase	19,42	TNF-alpha	tissue transglutaminase	7124	7052	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|role role|nmod|END_ENTITY	Protective role of tissue_transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells .
15935092	0	TNF-alpha	83,92	toll-like_receptor_4	47,67	TNF-alpha	toll-like receptor 4	24835(Tax:10116)	29260(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Chlamydophila_pneumoniae induces expression of toll-like_receptor_4 and release of TNF-alpha and MIP-2 via an NF-kappaB pathway in rat type II pneumocytes .
16285897	0	TNF-alpha	98,107	toll-like_receptor_4	144,164	TNF-alpha	toll-like receptor 4	7124	7099	Gene	Gene	release|amod|START_ENTITY elicit|dobj|release elicit|dep|not not|nmod|pathway pathway|nmod|END_ENTITY	Lipopolysaccharide could be internalized into human peripheral blood mononuclear cells and elicit TNF-alpha release , but not via the pathway of toll-like_receptor_4 on the cell surface .
19106809	0	TNF-alpha	0,9	toll-like_receptor_4	19,39	TNF-alpha	toll-like receptor 4	7124	7099	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	TNF-alpha inhibits toll-like_receptor_4 expression on monocytic cells via tristetraprolin during cardiopulmonary bypass .
20550956	0	TNF-alpha	33,42	toll-like_receptor_4	9,29	TNF-alpha	toll-like receptor 4	21926(Tax:10090)	21898(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Role for toll-like_receptor_4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin , a Trametes versicolor mushroom extract .
22574597	0	TNF-alpha	152,161	toll-like_receptor_4	76,96	TNF-alpha	toll-like receptor 4	7124	7099	Gene	Gene	-RSB-|amod|START_ENTITY transduction|dobj|-RSB- signal|acl|transduction signal|amod|END_ENTITY	-LSB- Effects of yiqi huoxue compound contained drug serum on the expressions of toll-like_receptor_4 and downstream signal transduction pathway , and LOX-1 , TNF-alpha , ICAM-1 in the human vein endothelial cells -RSB- .
1453299	0	TNF-alpha	171,180	tumor_necrosis_factor	148,169	TNF-alpha	tumor necrosis factor	7124	7124	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human choriogonadotropin -LRB- hCG -RRB- and placental_lactogen -LRB- hPL -RRB- inhibit interleukin-2 -LRB- IL-2 -RRB- and increase interleukin-1_beta -LRB- IL-1_beta -RRB- , -6 -LRB- IL-6 -RRB- and tumor_necrosis_factor -LRB- TNF-alpha -RRB- expression in monocyte cell cultures .
15230148	0	TNF-alpha	40,49	tumor_necrosis_factor	17,38	TNF-alpha	tumor necrosis factor	7124	7124	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	-LSB- Significance of tumor_necrosis_factor -LRB- TNF-alpha -RRB- in rheumatoid_arthritis -RSB- .
1666506	0	TNF-alpha	37,46	tumor_necrosis_factor	14,35	TNF-alpha	tumor necrosis factor	7124	7124	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of tumor_necrosis_factor -LRB- TNF-alpha -RRB- on calcium -LRB- Ca2 + -RRB- level .
1768744	1	TNF-alpha	83,92	tumor_necrosis_factor	60,81	TNF-alpha	tumor necrosis factor	7124	7124	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor -LRB- TNF-alpha -RRB- on human leucocytes .
10463815	0	TNF-alpha	46,55	tumor_necrosis_factor-alpha	17,44	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in serum by a highly sensitive enzyme amplified lanthanide luminescence immunoassay .
10488740	0	TNF-alpha	96,105	tumor_necrosis_factor-alpha	67,94	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Significant association of a single nucleotide polymorphism in the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene promoter with human narcolepsy .
10751892	0	TNF-alpha	87,96	tumor_necrosis_factor-alpha	58,85	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequent genotype changes at -308 , and 488 regions of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene in patients with prostate_cancer .
10880890	0	TNF-alpha	46,55	tumor_necrosis_factor-alpha	17,44	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- are essentially dependent on visceral fat amount in type 2 diabetic patients .
11457927	0	TNF-alpha	41,50	tumor_necrosis_factor-alpha	12,39	TNF-alpha	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in skeletal muscle regeneration .
11838052	0	TNF-alpha	77,86	tumor_necrosis_factor-alpha	49,76	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Response of keloid fibroblasts to the effect of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
12213594	0	TNF-alpha	42,51	tumor_necrosis_factor-alpha	13,40	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Reduction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- related nuclear_factor-kappaB -LRB- NF-kappaB -RRB- translocation but not inhibitor kappa-B -LRB- Ikappa-B -RRB- - degradation by Rho protein inhibition in human endothelial cells .
12527424	0	TNF-alpha	91,100	tumor_necrosis_factor-alpha	62,89	TNF-alpha	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	converting|amod|START_ENTITY converting|amod|END_ENTITY	Differential expression of plasminogen_activator_inhibitor-1 , tumor_necrosis_factor-alpha , TNF-alpha converting enzyme and ADAMTS family members in murine fat territories .
12657115	0	TNF-alpha	79,88	tumor_necrosis_factor-alpha	50,77	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism at the -308 - promoter position of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene and cervical_cancer .
12871593	0	TNF-alpha	42,51	tumor_necrosis_factor-alpha	13,40	TNF-alpha	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- by interleukin-12 p40 monomer and homodimer in microglia and macrophages .
14757367	0	TNF-alpha	84,93	tumor_necrosis_factor-alpha	55,82	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Serum_amyloid_A-induced mRNA expression and release of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human neutrophils .
15319168	0	TNF-alpha	50,59	tumor_necrosis_factor-alpha	21,48	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Relation between the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene and protein expression , and clinical , biochemical , and genetic markers : age , body mass index and uric_acid are independent predictors for an elevated TNF-alpha plasma level in a complex risk model .
15627647	0	TNF-alpha	81,90	tumor_necrosis_factor-alpha	52,79	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The -308 polymorphism in the promoter region of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive_periodontitis and/or type 1 diabetes_mellitus .
16422104	0	TNF-alpha	66,75	tumor_necrosis_factor-alpha	37,64	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Building immune microsphere against tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
16705808	0	TNF-alpha	84,93	tumor_necrosis_factor-alpha	55,82	TNF-alpha	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Diesel exhaust particles induce the over expression of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene in alveolar macrophages and failed to induce apoptosis through activation of nuclear_factor-kappaB -LRB- NF-kappaB -RRB- .
16932925	0	TNF-alpha	78,87	tumor_necrosis_factor-alpha	49,76	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Family and case-control association study of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene with schizophrenia and response to antipsychotic medication .
1747479	0	TNF-alpha	43,52	tumor_necrosis_factor-alpha	14,41	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	-LSB- Synthesis of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- by human monocytes in vitro -RSB- .
17537727	0	TNF-alpha	101,110	tumor_necrosis_factor-alpha	72,99	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
17607964	0	TNF-alpha	258,267	tumor_necrosis_factor-alpha	229,256	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
18176176	0	TNF-alpha	51,60	tumor_necrosis_factor-alpha	22,49	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
18510047	0	TNF-alpha	44,53	tumor_necrosis_factor-alpha	15,42	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on peritoneal fluid mononuclear cells in women with endometriosis -RSB- .
18618248	0	TNF-alpha	47,56	tumor_necrosis_factor-alpha	18,45	TNF-alpha	tumor necrosis factor-alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- by the intrathecal injection of lipopolysaccharide in the rat spinal cord .
18791857	0	TNF-alpha	72,81	tumor_necrosis_factor-alpha	43,70	TNF-alpha	tumor necrosis factor-alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Lipopolysaccharide-induced upregulation of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in rat spinal cord .
20097764	0	TNF-alpha	71,80	tumor_necrosis_factor-alpha	42,69	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Histone_deacetylase-3 activation promotes tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression in cardiomyocytes during lipopolysaccharide stimulation .
8522236	0	TNF-alpha	15,24	tumor_necrosis_factor-alpha	26,53	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- The effect of TNF-alpha -LRB- tumor_necrosis_factor-alpha -RRB- on progesterone synthesis in vitro by cells from ovarian follicular fluid in women -RSB- .
9355965	0	TNF-alpha	68,77	tumor_necrosis_factor-alpha	39,66	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	DNA polymorphisms and mutations of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- promoter in Langerhans_cell_histiocytosis -LRB- LCH -RRB- .
9528902	0	TNF-alpha	31,40	tumor_necrosis_factor-alpha	2,29	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	A tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- promoter polymorphism is associated with chronic hepatitis_B_infection .
9667368	0	TNF-alpha	37,46	tumor_necrosis_factor-alpha	8,35	TNF-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Soluble tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- receptors in human colostrum and milk bind to TNF-alpha and neutralize TNF-alpha bioactivity .
11566620	0	TNF-alpha	47,56	tumor_necrosis_factor_alpha	18,45	TNF-alpha	tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Direct effects of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- on murine skeletal muscle cell lines .
11750953	0	TNF-alpha	49,58	tumor_necrosis_factor_alpha	20,47	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Predictive value of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- in preeclampsia .
12644782	0	TNF-alpha	132,141	tumor_necrosis_factor_alpha	103,130	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Hereditary , familial , and idiopathic_chronic_pancreatitis are not associated with polymorphisms in the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- promoter region or the TNF_receptor_1 -LRB- TNFR1 -RRB- gene .
1467365	0	TNF-alpha	40,49	tumor_necrosis_factor_alpha	11,38	TNF-alpha	tumor necrosis factor alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- on collagen_arthritis .
14767724	0	TNF-alpha	94,103	tumor_necrosis_factor_alpha	65,92	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis of the -308 G > A promoter polymorphism of the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- gene in Japanese patients with schizophrenia .
15050606	0	TNF-alpha	67,76	tumor_necrosis_factor_alpha	38,65	TNF-alpha	tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interleukin-1_beta -LRB- IL-1beta -RRB- induces tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation .
15659876	0	TNF-alpha	47,56	tumor_necrosis_factor_alpha	18,45	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Direct effects of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- on L6 myotubes .
15865250	0	TNF-alpha	52,61	tumor_necrosis_factor_alpha	13,40	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	-LSB- The role of tumor_necrosis_factor_alpha receptors -LRB- TNF-alpha -RRB- in psoriasis and other skin_disorders -RSB- .
1740661	0	TNF-alpha	50,59	tumor_necrosis_factor_alpha	21,48	TNF-alpha	tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- gene correlate with murine resistance to development of toxoplasmic_encephalitis and with levels of TNF-alpha mRNA in infected brain tissue .
17481363	0	TNF-alpha	93,102	tumor_necrosis_factor_alpha	64,91	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Analysis and quantitation of NF-kappaB nuclear translocation in tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- activated vascular endothelial cells .
18560829	0	TNF-alpha	97,106	tumor_necrosis_factor_alpha	68,95	TNF-alpha	tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Establishment of a cell-based assay for examining the expression of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- gene .
20926563	0	TNF-alpha	50,59	tumor_necrosis_factor_alpha	21,48	TNF-alpha	tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Genomic profiling of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus_infection .
21502320	0	TNF-alpha	83,92	tumor_necrosis_factor_alpha	54,81	TNF-alpha	tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
2164226	0	TNF-alpha	51,60	tumor_necrosis_factor_alpha	22,49	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Characterization of a tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- inhibitor : evidence of immunological cross-reactivity with the TNF receptor .
2822458	0	TNF-alpha	40,49	tumor_necrosis_factor_alpha	11,38	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- to high-affinity receptors on polymorphonuclear cells .
8360023	0	TNF-alpha	55,64	tumor_necrosis_factor_alpha	26,53	TNF-alpha	tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The paradoxical effect of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- in endotoxin-induced uveitis .
8768061	0	TNF-alpha	46,55	tumor_necrosis_factor_alpha	17,44	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	-LSB- Significance of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- in endometriosis -RSB- .
9037662	0	TNF-alpha	44,53	tumor_necrosis_factor_alpha	15,42	TNF-alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	The release of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- by interferon_gamma _ -LRB- IFN-gamma -RRB- induced THP-1 cells stimulated with smooth lipopolysaccharide is inhibited by MAbs against HLA-DR and CD14 receptors on the effector cell .
9200478	0	TNF-alpha	128,137	type_II_phospholipase_A2	168,192	TNF-alpha	type II phospholipase A2	100135630(Tax:10141)	100135599(Tax:10141)	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Endotoxin induces expression of type_II_phospholipase_A2 in macrophages during acute_lung_injury in guinea_pigs : involvement of TNF-alpha in lipopolysaccharide-induced type_II_phospholipase_A2 synthesis .
25077985	0	TNF-alpha	23,32	uncoupling_protein_2	48,68	TNF-alpha	uncoupling protein 2	21926(Tax:10090)	22228(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Antagonistic effect of TNF-alpha and insulin on uncoupling_protein_2 -LRB- UCP-2 -RRB- expression and vascular_damage .
16459338	0	TNF-alpha_converting_enzyme	40,67	TACE	69,73	TNF-alpha converting enzyme	TACE	6868	6868	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Stabilization of the autoproteolysis of TNF-alpha_converting_enzyme -LRB- TACE -RRB- results in a novel crystal form suitable for structure-based drug design studies .
16511637	0	TNF-alpha_converting_enzyme	0,27	TACE	29,33	TNF-alpha converting enzyme	TACE	6868	6868	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	TNF-alpha_converting_enzyme -LRB- TACE -RRB- protein expression in different clinical subtypes of multiple_sclerosis .
17936631	0	TNF-alpha_converting_enzyme	14,41	TACE	43,47	TNF-alpha converting enzyme	TACE	6868	6868	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Chromen-based TNF-alpha_converting_enzyme -LRB- TACE -RRB- inhibitors : design , synthesis , and biological evaluation .
19729328	0	TNF-alpha_converting_enzyme	34,61	TACE	63,67	TNF-alpha converting enzyme	TACE	6868	6868	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Prediction of novel and selective TNF-alpha_converting_enzyme -LRB- TACE -RRB- inhibitors and characterization of correlative molecular descriptors by machine learning approaches .
20022498	0	TNF-alpha_converting_enzyme	38,65	TACE	67,71	TNF-alpha converting enzyme	TACE	6868	6868	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	The discovery of novel tartrate-based TNF-alpha_converting_enzyme -LRB- TACE -RRB- inhibitors .
8660797	0	TNF-alpha_receptor	38,56	TNF-alpha	92,101	TNF-alpha receptor	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Evidence for endogenous C1q modulates TNF-alpha_receptor synthesis and autocrine binding of TNF-alpha associated with lipid A activation of murine macrophages for nitric_oxide production .
24696164	0	TNF-b	28,33	Tumor_necrosis_factor_beta	0,26	TNF-b	Tumor necrosis factor beta	4049	4049	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Tumor_necrosis_factor_beta -LRB- TNF-b -RRB- NcoI polymorphism is associated with multiple_sclerosis in Caucasian patients from Southern Brazil independently from HLA-DRB1 .
17483704	0	TNF-beta	11,19	IL-10	27,32	TNF-beta	IL-10	4049	3586	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
17483704	0	TNF-beta	11,19	IL-6	21,25	TNF-beta	IL-6	4049	3569	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|appos|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
1670638	0	TNF-beta	118,126	TNF	52,55	TNF-beta	TNF	4049	7124	Gene	Gene	gene|amod|START_ENTITY intron|nmod|gene polymorphism|nmod|intron correlates|nsubj|polymorphism locus|parataxis|correlates locus|nsubj|structure structure|nmod|tumor_necrosis_factor tumor_necrosis_factor|appos|END_ENTITY	Polymorphic structure of the tumor_necrosis_factor -LRB- TNF -RRB- locus : an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino_acid in position 26 and a reduced level of TNF-beta production .
17767060	0	TNF-beta	32,40	TNF	65,68	TNF-beta	TNF	4049	7124	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of gene polymorphism of TNF-beta on the concentration of TNF in serum of patient with endometriosis -RSB- .
2249779	0	TNF-beta	75,83	TNF	34,37	TNF-beta	TNF	100328931(Tax:9986)	100009088(Tax:9986)	Gene	Gene	encoding|dobj|START_ENTITY containing|advcl|encoding locus|xcomp|containing locus|nsubj|analysis analysis|nmod|END_ENTITY	Structural analysis of the rabbit TNF locus , containing the genes encoding TNF-beta -LRB- lymphotoxin -RRB- and TNF-alpha -LRB- tumor necrosis factor -RRB- .
16276011	0	TNF-beta	11,19	TNF-alpha	0,9	TNF-beta	TNF-alpha	4049	7124	Gene	Gene	polymorphisms|nsubj|START_ENTITY polymorphisms|advmod|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , and IL-10 polymorphisms in patients with lung_cancer .
1697319	0	TNF-beta	112,120	TNF-alpha	84,93	TNF-beta	TNF-alpha	4049	7124	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	Highly sensitive enzyme immunoassays for antibodies to human tumor_necrosis_factor -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- .
1708843	0	TNF-beta	0,8	TNF-alpha	44,53	TNF-beta	TNF-alpha	4049	7124	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	TNF-beta -LRB- lymphotoxin -RRB- strongly upregulates TNF-alpha gene expression in human peripheral blood lymphocytes .
17483704	0	TNF-beta	11,19	TNF-alpha	0,9	TNF-beta	TNF-alpha	4049	7124	Gene	Gene	PECAM-1|appos|START_ENTITY PECAM-1|compound|END_ENTITY	TNF-alpha , TNF-beta , IL-6 , IL-10 , PECAM-1 and the MPO inflammatory gene polymorphisms in osteosarcoma .
2329277	0	TNF-beta	65,73	TNF-alpha	37,46	TNF-beta	TNF-alpha	16992(Tax:10090)	21926(Tax:10090)	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	Production of tumor_necrosis_factor -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- by murine pre-B and B cell lymphomas .
3490653	0	TNF-beta	65,73	TNF-alpha	37,46	TNF-beta	TNF-alpha	16992(Tax:10090)	21926(Tax:10090)	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	The genes for tumor_necrosis_factor -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- are tandemly arranged on chromosome 17 of the mouse .
7808952	1	TNF-beta	138,146	TNF-alpha	110,119	TNF-beta	TNF-alpha	4049	7124	Gene	Gene	cachectin|appos|START_ENTITY cachectin|appos|END_ENTITY	Effect of cachectin -LRB- TNF-alpha -RRB- and lymphotoxin -LRB- TNF-beta -RRB- on human erythropoiesis -RSB- .
17507094	0	TNF-receptor-associated-factor-6	73,105	TLR4	15,19	TNF-receptor-associated-factor-6	TLR4	22034(Tax:10090)	21898(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Sensitivity of TLR4 - and -7 - induced NF_kappa_B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages .
10021364	0	TNF-receptor-associated_factor	13,43	Misshapen	74,83	TNF-receptor-associated factor	Misshapen	33638(Tax:7227)	44030(Tax:7227)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	A Drosophila TNF-receptor-associated_factor -LRB- TRAF -RRB- binds the ste20 kinase Misshapen and activates Jun_kinase .
11741951	0	TNF-related_activation-induced_cytokine	0,39	Src	96,99	TNF-related activation-induced cytokine	Src	8600	6714	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	TNF-related_activation-induced_cytokine -LRB- TRANCE -RRB- induces angiogenesis through the activation of Src and phospholipase C -LRB- PLC -RRB- in human endothelial cells .
10946322	0	TNF-related_apoptosis-inducing_ligand	36,73	Apo-2_ligand	74,86	TNF-related apoptosis-inducing ligand	Apo-2 ligand	8743	8743	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Adenoviral-mediated transfer of the TNF-related_apoptosis-inducing_ligand / Apo-2_ligand gene induces tumor cell apoptosis .
12817000	0	TNF-related_apoptosis-inducing_ligand	54,91	IFN-alpha	36,45	TNF-related apoptosis-inducing ligand	IFN-alpha	8743	3439	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Plasmacytoid dendritic cell-derived IFN-alpha induces TNF-related_apoptosis-inducing_ligand / Apo-2L-mediated antitumor activity by human monocytes following CpG oligodeoxynucleotide stimulation .
16584980	0	TNF-related_apoptosis-inducing_ligand	0,37	PKC_epsilon	77,88	TNF-related apoptosis-inducing ligand	PKC epsilon	8743	5581	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- and erythropoiesis : a role for PKC_epsilon .
19364504	0	TNF-related_apoptosis-inducing_ligand	0,37	PRDX4	49,54	TNF-related apoptosis-inducing ligand	PRDX4	8743	10549	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	TNF-related_apoptosis-inducing_ligand suppresses PRDX4 expression .
10364001	0	TNF-related_apoptosis-inducing_ligand	12,49	TRAIL	51,56	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Relation of TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma .
11240708	0	TNF-related_apoptosis-inducing_ligand	21,58	TRAIL	14,19	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Expression of TRAIL -LRB- TNF-related_apoptosis-inducing_ligand -RRB- receptors in cervical_cancer .
12738989	0	TNF-related_apoptosis-inducing_ligand	58,95	TRAIL	97,102	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cell to cell contact required for bystander effect of the TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- gene .
15539085	0	TNF-related_apoptosis-inducing_ligand	14,51	TRAIL	53,58	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- in megakaryocytes and platelets .
15608694	0	TNF-related_apoptosis-inducing_ligand	42,79	TRAIL	81,86	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Histone deacetylase inhibitors potentiate TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis in lymphoid_malignancies .
16941746	0	TNF-related_apoptosis-inducing_ligand	30,67	TRAIL	69,74	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hydrogen_peroxide upregulates TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- expression in human astroglial cells , and augments apoptosis of T cells .
22202560	0	TNF-related_apoptosis-inducing_ligand	26,63	TRAIL	65,70	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- and TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- levels in malignant_and_benign_pericardial_effusions .
23492758	0	TNF-related_apoptosis-inducing_ligand	10,47	TRAIL	49,54	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- show a long-term stability in the breast milk of mothers of preterm infants .
24771425	0	TNF-related_apoptosis-inducing_ligand	27,64	TRAIL	20,25	TNF-related apoptosis-inducing ligand	TRAIL	22035(Tax:10090)	22035(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Systemic effects of TRAIL -LRB- TNF-related_apoptosis-inducing_ligand -RRB- during acute y-irradiation .
25813908	0	TNF-related_apoptosis-inducing_ligand	10,47	TRAIL	49,54	TNF-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Low serum TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- levels are associated with acute ischemic_stroke severity .
20951133	0	TNF-related_apoptosis-inducing_ligand	75,112	caspase_8	58,67	TNF-related apoptosis-inducing ligand	caspase 8	8743	841	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Cellular_inhibitor_of_apoptosis_1 -LRB- cIAP-1 -RRB- degradation by caspase_8 during TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis .
25981737	0	TNF-related_apoptosis-inducing_ligand	0,37	midline-1	56,65	TNF-related apoptosis-inducing ligand	midline-1	22035(Tax:10090)	17318(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- regulates midline-1 , thymic_stromal_lymphopoietin , inflammation , and remodeling in experimental eosinophilic_esophagitis .
10502402	0	TNF-related_apoptosis_inducing_ligand	14,51	TRAIL	7,12	TNF-related apoptosis inducing ligand	TRAIL	22035(Tax:10090)	22035(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Murine TRAIL -LRB- TNF-related_apoptosis_inducing_ligand -RRB- expression induced by T cell activation is blocked by rapamycin , cyclosporin_A , and inhibitors of phosphatidylinositol 3-kinase , protein kinase C , and protein tyrosine kinases : evidence for TRAIL induction via the T cell receptor signaling pathway .
16040132	0	TNF-related_apoptosis_inducing_ligand	0,37	TRAIL	39,44	TNF-related apoptosis inducing ligand	TRAIL	8743	8743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	TNF-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- gene polymorphism in Japanese patients with multiple_sclerosis .
19292615	0	TNF-related_weak_inducer_of_apoptosis	27,64	sclerostin	161,171	TNF-related weak inducer of apoptosis	sclerostin	8742	50964	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Pro-inflammatory cytokines TNF-related_weak_inducer_of_apoptosis -LRB- TWEAK -RRB- and TNFalpha induce the mitogen-activated protein kinase -LRB- MAPK -RRB- - dependent expression of sclerostin in human osteoblasts .
24971461	0	TNFA	87,91	TLR4	54,58	TNFA	TLR4	7124	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
22487520	0	TNFA	16,20	TNF-alpha	0,9	TNFA	TNF-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	TNF-alpha gene -LRB- TNFA -RRB- variants increase risk for multi-organ_dysfunction_syndrome -LRB- MODS -RRB- in acute pancreatitis .
25398810	0	TNFA	46,50	tumor_necrosis_factor-a	21,44	TNFA	tumor necrosis factor-a	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relationship between tumor_necrosis_factor-a -LRB- TNFA -RRB- gene polymorphisms and cardiac_sarcoidosis .
11393654	0	TNFA	171,175	tumor_necrosis_factor-alpha	137,164	TNFA	tumor necrosis factor-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism -LRB- SNP -RRB- sites in the tumor_necrosis_factor-alpha gene -LRB- TNFA -RRB- promoter .
7557979	0	TNFA	86,90	tumor_necrosis_factor_alpha	57,84	TNFA	tumor necrosis factor alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of a C-insertion polymorphism within the human tumor_necrosis_factor_alpha -LRB- TNFA -RRB- gene .
9184006	0	TNFA	90,94	tumor_necrosis_factor_alpha	61,88	TNFA	tumor necrosis factor alpha	7124	7124	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	NcoI restriction fragment length polymorphism at -308 of the tumor_necrosis_factor_alpha -LRB- TNFA -RRB- promoter region in Korean .
22810651	0	TNFAIP1	0,7	KCTD10	23,29	TNFAIP1	KCTD10	7126	83892	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-kB and AP-1 .
22810651	0	TNFAIP1	0,7	KCTD10	60,66	TNFAIP1	KCTD10	7126	83892	Gene	Gene	interacts|nsubj|START_ENTITY interacts|xcomp|promote promote|dobj|degradation degradation|nmod|proteins proteins|nummod|END_ENTITY	TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-kB and AP-1 .
26261520	0	TNFAIP1	70,77	MiRNA-15a	0,9	TNFAIP1	MiRNA-15a	7126	406948	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiRNA-15a inhibits proliferation , migration and invasion by targeting TNFAIP1 in human osteosarcoma cells .
19637314	0	TNFAIP1	51,58	RhoB	0,4	TNFAIP1	RhoB	7126	388	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells .
23975427	0	TNFAIP2	47,54	LMP1	94,98	TNFAIP2	LMP1	7127	9260	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	NF-kB-mediated transcriptional upregulation of TNFAIP2 by the Epstein-Barr_virus oncoprotein , LMP1 , promotes cell motility in nasopharyngeal_carcinoma .
21934093	0	TNFAIP2	52,59	miR-184	28,35	TNFAIP2	miR-184	7127	406960	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous_cell_carcinoma_of_the_head_and_neck .
20822710	0	TNFAIP3	25,32	A20	34,37	TNFAIP3	A20	7128	7128	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Functional evaluation of TNFAIP3 -LRB- A20 -RRB- in rheumatoid_arthritis .
26199174	0	TNFAIP3	25,32	A20	34,37	TNFAIP3	A20	7128	7128	Gene	Gene	alterations|nmod|START_ENTITY alterations|appos|END_ENTITY	Recurrent alterations of TNFAIP3 -LRB- A20 -RRB- in T-cell_large_granular_lymphocytic_leukemia .
21763284	0	TNFAIP3	16,23	miR-29c	0,7	TNFAIP3	miR-29c	7128	407026	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-29c targets TNFAIP3 , inhibits cell proliferation and induces apoptosis in hepatitis_B virus-related hepatocellular_carcinoma .
9521690	0	TNFR	99,103	CD95	44,48	TNFR	CD95	7132	355	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of the ligand binding site in Fas -LRB- CD95 -RRB- by site-directed mutagenesis and comparison with TNFR and CD40 .
9391689	0	TNFR	74,78	tumor_necrosis_factor	18,39	TNFR	tumor necrosis factor	7132	7124	Gene	Gene	protein|appos|START_ENTITY Fc|dobj|protein Fc|nsubj|receptor receptor|compound|END_ENTITY	Recombinant human tumor_necrosis_factor receptor -LRB- p75 -RRB- Fc fusion protein -LRB- TNFR : Fc -RRB- in rheumatoid_arthritis .
9684796	0	TNFR	63,67	tumor_necrosis_factor	12,33	TNFR	tumor necrosis factor	7132	7124	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Recombinant tumor_necrosis_factor receptor p75 fusion protein -LRB- TNFR : Fc -RRB- alters endotoxin-induced activation of the kinin , fibrinolytic , and coagulation systems in normal humans .
21074606	0	TNFR1	0,5	CD40	23,27	TNFR1	CD40	21937(Tax:10090)	21939(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	TNFR1 is essential for CD40 , but not for lipopolysaccharide-induced sickness_behavior and clock gene dysregulation .
15699216	0	TNFR1	19,24	CDK4	0,4	TNFR1	CDK4	7132	1019	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control .
24767863	0	TNFR1	63,68	HP0986	28,34	TNFR1	HP0986	21937(Tax:10090)	899519(Tax:85962)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Helicobacter_pylori protein HP0986 -LRB- TieA -RRB- interacts with mouse TNFR1 and triggers proinflammatory and proapoptotic signaling pathways in cultured macrophage cells -LRB- RAW 264.7 -RRB- .
17070836	0	TNFR1	134,139	IL-6	84,88	TNFR1	IL-6	21938(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY role|nmod|receptor differences|dep|role differences|appos|expression expression|compound|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
19527232	0	TNFR1	53,58	IL-6	12,16	TNFR1	IL-6	7132	3569	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of IL-6 , IL-10 , TNF-alpha and its receptors TNFR1 and TNFR2 in the local regulatory system of normal and impaired human spermatogenesis .
26877205	0	TNFR1	40,45	RIPK1	8,13	TNFR1	RIPK1	7132	8737	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling .
17070836	0	TNFR1	134,139	TNF	120,123	TNFR1	TNF	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
17070836	0	TNFR1	134,139	TNF	79,82	TNFR1	TNF	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY role|nmod|receptor differences|dep|role differences|appos|END_ENTITY	Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF , TNF , IL-6 expression : role of the 55 kDa TNF receptor -LRB- TNFR1 -RRB- .
18317365	0	TNFR1	46,51	TNF	135,138	TNFR1	TNF	7132	7124	Gene	Gene	tumor_necrosis_factor_receptor_1|appos|START_ENTITY tumor_necrosis_factor_receptor_1|dep|antibody antibody|nmod|inhibition inhibition|nmod|action action|appos|END_ENTITY	A humanized tumor_necrosis_factor_receptor_1 -LRB- TNFR1 -RRB- - specific antagonistic antibody for selective inhibition of tumor_necrosis_factor -LRB- TNF -RRB- action .
20045350	0	TNFR1	92,97	TNF	58,61	TNFR1	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	selectivity|nmod|START_ENTITY expressing|nmod|selectivity expressing|dobj|variants variants|compound|END_ENTITY	Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2 .
20206684	0	TNFR1	153,158	TNF	13,16	TNFR1	TNF	7132	7124	Gene	Gene	formation|nmod|START_ENTITY stoichiometry|nmod|formation reveal|dobj|stoichiometry reveal|nsubj|derivatives derivatives|compound|END_ENTITY	Single chain TNF derivatives with individually mutated receptor binding sites reveal differential stoichiometry of ligand receptor complex formation for TNFR1 and TNFR2 .
25995337	0	TNFR1	76,81	TNF	53,56	TNFR1	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nmod|END_ENTITY	Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1 .
9464804	0	TNFR1	55,60	TNF	127,130	TNFR1	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY expressing|dobj|protein transgenic_mice|acl|expressing sensitivity|nmod|transgenic_mice sensitivity|dep|action action|nmod|END_ENTITY	High sensitivity of transgenic_mice expressing soluble TNFR1 fusion protein to mycobacterial_infections : synergistic action of TNF and IFN-gamma in the differentiation of protective granulomas .
25263964	0	TNFR1	28,33	TNF-a	21,26	TNFR1	TNF-a	7132	7124	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the TNF-a , TNFR1 gene and risk of rheumatoid_arthritis in Chinese Han population .
25416967	0	TNFR1	60,65	TNF-a	43,48	TNFR1	TNF-a	7132	7124	Gene	Gene	responses|appos|START_ENTITY responses|nmod|receptors receptors|amod|END_ENTITY	Differential pro-inflammatory responses of TNF-a receptors -LRB- TNFR1 and TNFR2 -RRB- on LOX-1 signalling .
18187611	0	TNFR1	19,24	TNF-alpha	0,9	TNFR1	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|amod|END_ENTITY	TNF-alpha acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle .
26268655	3	TNFR1	437,442	TNFR2	448,453	TNFR1	TNFR2	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	CD4|amod|START_ENTITY CD4|compound|END_ENTITY	We previously showed reduced IL-2 production in TNFR1 -LRB- - / - -RRB- TNFR2 -LRB- - / - -RRB- CD4 -LRB- + -RRB- T cells .
12644782	0	TNFR1	182,187	TNF_receptor_1	166,180	TNFR1	TNF receptor 1	7132	7132	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hereditary , familial , and idiopathic_chronic_pancreatitis are not associated with polymorphisms in the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- promoter region or the TNF_receptor_1 -LRB- TNFR1 -RRB- gene .
20472056	0	TNFR1	29,34	Ubc13	20,25	TNFR1	Ubc13	7132	7334	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	A novel function of Ubc13 in TNFR1 receptor activation .
11110059	0	TNFR1	101,106	tumor_necrosis_factor_receptor_1	67,99	TNFR1	tumor necrosis factor receptor 1	7132	7132	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Treatment with the pure antiestrogen faslodex -LRB- ICI_182780 -RRB- induces tumor_necrosis_factor_receptor_1 -LRB- TNFR1 -RRB- expression in MCF-7 breast_cancer cells .
18453563	0	TNFR2	28,33	CD25	86,90	TNFR2	CD25	21938(Tax:10090)	16184(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY defines|nsubj|expression defines|dobj|subset subset|nmod|cells cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
18453563	0	TNFR2	28,33	CD4	82,85	TNFR2	CD4	21938(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY defines|nsubj|expression defines|dobj|subset subset|nmod|cells cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
19551899	0	TNFR2	8,13	CD4	28,31	TNFR2	CD4	21938(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Lack of TNFR2 expression by CD4 -LRB- + -RRB- T cells exacerbates experimental colitis .
20127680	0	TNFR2	17,22	CD4	66,69	TNFR2	CD4	7133	920	Gene	Gene	Co-expression|nmod|START_ENTITY identifies|nsubj|Co-expression identifies|dep|+ +|nsubj|more more|nmod|FOXP3 FOXP3|compound|END_ENTITY	Co-expression of TNFR2 and CD25 identifies more of the functional CD4 + FOXP3 + regulatory T cells in human peripheral blood .
20173391	0	TNFR2	37,42	CD4	27,30	TNFR2	CD4	21938(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20525892	0	TNFR2	28,33	CD4	106,109	TNFR2	CD4	21938(Tax:10090)	12504(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY induces|nsubj|Expression induces|nmod|cells cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	TNFR2	28,33	CD4	56,59	TNFR2	CD4	21938(Tax:10090)	12504(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY induces|nsubj|Expression induces|dobj|resistance resistance|nmod|FoxP3 FoxP3|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
23277487	0	TNFR2	0,5	CD4	47,50	TNFR2	CD4	21938(Tax:10090)	12504(Tax:10090)	Gene	Gene	critical|nsubj|START_ENTITY critical|nmod|stabilization stabilization|nmod|phenotype phenotype|compound|END_ENTITY	TNFR2 is critical for the stabilization of the CD4 + Foxp3 + regulatory T. cell phenotype in the inflammatory environment .
23964278	0	TNFR2	0,5	CD4	77,80	TNFR2	CD4	7133	920	Gene	Gene	Expression|compound|START_ENTITY T|nsubj|Expression T|dobj|Induced Induced|nmod|Stimulation Stimulation|nmod|Effectors Effectors|compound|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
20127680	0	TNFR2	17,22	FOXP3	70,75	TNFR2	FOXP3	7133	50943	Gene	Gene	Co-expression|nmod|START_ENTITY identifies|nsubj|Co-expression identifies|dep|+ +|nsubj|more more|nmod|END_ENTITY	Co-expression of TNFR2 and CD25 identifies more of the functional CD4 + FOXP3 + regulatory T cells in human peripheral blood .
23964278	0	TNFR2	0,5	FOXP3	28,33	TNFR2	FOXP3	7133	50943	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	TNFR2 Expression on CD25 -LRB- hi -RRB- FOXP3 -LRB- + -RRB- T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors .
18453563	0	TNFR2	28,33	FoxP3	91,96	TNFR2	FoxP3	21938(Tax:10090)	20371(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY defines|nsubj|expression defines|dobj|subset subset|nmod|cells cells|compound|END_ENTITY	Cutting edge : expression of TNFR2 defines a maximally suppressive subset of mouse CD4 + CD25 + FoxP3 + T regulatory cells : applicability to tumor-infiltrating T regulatory cells .
20173391	0	TNFR2	37,42	FoxP3	31,36	TNFR2	FoxP3	21938(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
20525892	0	TNFR2	28,33	FoxP3	110,115	TNFR2	FoxP3	21938(Tax:10090)	20371(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY induces|nsubj|Expression induces|nmod|cells cells|compound|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
20525892	0	TNFR2	28,33	FoxP3	60,65	TNFR2	FoxP3	21938(Tax:10090)	20371(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY induces|nsubj|Expression induces|dobj|resistance resistance|nmod|END_ENTITY	Expression of costimulatory TNFR2 induces resistance of CD4 + FoxP3 - conventional T cells to suppression by CD4 + FoxP3 + regulatory T cells .
22105853	0	TNFR2	0,5	Foxp3	50,55	TNFR2	Foxp3	21937(Tax:10090)	20371(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|compound|END_ENTITY	TNFR2 on non-haematopoietic cells is required for Foxp3 + Treg-cell function and disease suppression in EAE .
23277487	0	TNFR2	0,5	Foxp3	51,56	TNFR2	Foxp3	21938(Tax:10090)	20371(Tax:10090)	Gene	Gene	critical|nsubj|START_ENTITY critical|nmod|stabilization stabilization|nmod|phenotype phenotype|compound|END_ENTITY	TNFR2 is critical for the stabilization of the CD4 + Foxp3 + regulatory T. cell phenotype in the inflammatory environment .
20401725	0	TNFR2	24,29	GSTT1	41,46	TNFR2	GSTT1	7133	2952	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association analysis of TNFR2 , VDR , A2M , GSTT1 , GSTM1 , and ACE genes with rheumatoid_arthritis in South Asians and Caucasians of East Midlands in the United Kingdom .
24703938	0	TNFR2	104,109	Progranulin	0,11	TNFR2	Progranulin	7133	2896	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Progranulin is required for proper ER stress response and inhibits ER stress-mediated apoptosis through TNFR2 .
20173391	0	TNFR2	37,42	TNF-alpha	0,9	TNFR2	TNF-alpha	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY activator|nmod|cells END_ENTITY|dep|activator	TNF-alpha : an activator of CD4 + FoxP3 + TNFR2 + regulatory T cells .
26268655	3	TNFR2	448,453	TNFR1	437,442	TNFR2	TNFR1	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	CD4|compound|START_ENTITY CD4|amod|END_ENTITY	We previously showed reduced IL-2 production in TNFR1 -LRB- - / - -RRB- TNFR2 -LRB- - / - -RRB- CD4 -LRB- + -RRB- T cells .
24318359	0	TNFR2	38,43	TRAF2	2,7	TNFR2	TRAF2	7133	7186	Gene	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 .
16020544	0	TNFR2	34,39	Tumor_necrosis_factor_receptor_2	0,32	TNFR2	Tumor necrosis factor receptor 2	7133	7133	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- signaling is negatively regulated by a novel , carboxyl-terminal TNFR-associated_factor_2 -LRB- TRAF2 -RRB- - binding site .
20401725	0	TNFR2	24,29	VDR	31,34	TNFR2	VDR	7133	7421	Gene	Gene	GSTM1|compound|START_ENTITY GSTM1|appos|END_ENTITY	Association analysis of TNFR2 , VDR , A2M , GSTT1 , GSTM1 , and ACE genes with rheumatoid_arthritis in South Asians and Caucasians of East Midlands in the United Kingdom .
15906094	0	TNFR2	86,91	interleukin-6	21,34	TNFR2	interleukin-6	7133	3569	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Association tests of interleukin-6 -LRB- IL-6 -RRB- and type II tumor_necrosis_factor receptor -LRB- TNFR2 -RRB- genes with bone_mineral_density in Caucasians using a re-sampling approach .
11196666	0	TNFR2	31,36	p75	38,41	TNFR2	p75	7133	7133	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A bi-allelic VNTR in the human TNFR2 -LRB- p75 -RRB- gene promoter .
16273297	0	TNFR2	40,45	p75_TNF_receptor	22,38	TNFR2	p75 TNF receptor	7133	7133	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Lovastatin stimulates p75_TNF_receptor -LRB- TNFR2 -RRB- expression in primary human endothelial cells .
15906094	0	TNFR2	86,91	tumor_necrosis_factor	54,75	TNFR2	tumor necrosis factor	7133	7124	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Association tests of interleukin-6 -LRB- IL-6 -RRB- and type II tumor_necrosis_factor receptor -LRB- TNFR2 -RRB- genes with bone_mineral_density in Caucasians using a re-sampling approach .
11144293	0	TNFR2	65,70	tumor_necrosis_factor_receptor_2	31,63	TNFR2	tumor necrosis factor receptor 2	7133	7133	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Significant association of the tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- gene with human narcolepsy .
11781288	0	TNFR2	42,47	tumor_necrosis_factor_receptor_2	8,40	TNFR2	tumor necrosis factor receptor 2	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- in colonic_epithelial_hyperplasia_and_chronic_intestinal_inflammation in mice .
12218076	0	TNFR2	46,51	tumor_necrosis_factor_receptor_2	12,44	TNFR2	tumor necrosis factor receptor 2	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- in cerebral_malaria in mice .
7927340	0	TNFR2	57,62	tumor_necrosis_factor_receptor_2	23,55	TNFR2	tumor necrosis factor receptor 2	7133	7133	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Linkage mapping of the tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- gene to 1p36 .2 using the single-strand conformation polymorphism technique .
21903966	0	TNFRSF11B	80,89	osteoprotegerin	58,73	TNFRSF11B	osteoprotegerin	4982	4982	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assessment of the genetic effects of polymorphisms in the osteoprotegerin gene , TNFRSF11B , on serum osteoprotegerin levels and carotid plaque vulnerability .
21994215	0	TNFRSF11B	36,45	osteoprotegerin	47,62	TNFRSF11B	osteoprotegerin	4982	4982	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms within the TNFRSF11B -LRB- osteoprotegerin -RRB- gene increase the risk for low bone mineral density .
19392801	0	TNFRSF13B	29,38	TACI	40,44	TNFRSF13B	TACI	23495	23495	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Role of polymorphisms in the TNFRSF13B -LRB- TACI -RRB- gene in Spanish patients with immunoglobulin_A_deficiency .
19494827	0	TNFRSF13B	115,124	tumor_necrosis_factor_receptor_superfamily_member_13B	60,113	TNFRSF13B	tumor necrosis factor receptor superfamily member 13B	23495	23495	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	An evolutionary approach to the medical implications of the tumor_necrosis_factor_receptor_superfamily_member_13B -LRB- TNFRSF13B -RRB- gene .
22699762	0	TNFRSF13C	80,89	APRIL	109,114	TNFRSF13C	APRIL	115650	8741	Gene	Gene	TNFRSF13B|appos|START_ENTITY classifications|appos|TNFRSF13B classifications|appos|TNFSF13 TNFSF13|appos|END_ENTITY	Three different classifications , B lymphocyte subpopulations , TNFRSF13B -LRB- TACI -RRB- , TNFRSF13C -LRB- BAFF-R -RRB- , TNFSF13 -LRB- APRIL -RRB- gene mutations , CTLA-4 and ICOS gene polymorphisms in Turkish patients with common_variable_immunodeficiency .
24623448	0	TNFRSF19	39,47	b-catenin	0,9	TNFRSF19	b-catenin	55504	1499	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	b-catenin regulates NF-kB activity via TNFRSF19 in colorectal_cancer cells .
24971461	0	TNFRSF1A	93,101	TLR4	54,58	TNFRSF1A	TLR4	7132	7099	Gene	Gene	PTPN22|appos|START_ENTITY PTPN22|compound|END_ENTITY	Polymorphisms in the inflammatory pathway genes TLR2 , TLR4 , TLR9 , LY96 , NFKBIA , NFKB1 , TNFA , TNFRSF1A , IL6R , IL10 , IL23R , PTPN22 , and PPARG are associated with susceptibility of inflammatory_bowel_disease in a Danish cohort .
16093357	0	TNFRSF1B	86,94	Tnfrsf1a	117,125	TNFRSF1B	Tnfrsf1a	156767(Tax:10116)	25625(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Experimental intestinal endometriosis is characterized by increased levels of soluble TNFRSF1B and downregulation of Tnfrsf1a and Tnfrsf1b gene expression .
11357933	0	TNFRSF1B	39,47	Tumor_necrosis_factor_receptor_2	0,32	TNFRSF1B	Tumor necrosis factor receptor 2	7133	7133	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tumor_necrosis_factor_receptor_2 gene -LRB- TNFRSF1B -RRB- in genetic basis of coronary_artery_disease .
25915578	0	TNFRSF8	115,122	tumor_necrosis_factor_receptor_superfamily_member_8	62,113	TNFRSF8	tumor necrosis factor receptor superfamily member 8	943	943	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The potential of interleukin_12_receptor_beta_2 -LRB- IL12RB2 -RRB- and tumor_necrosis_factor_receptor_superfamily_member_8 -LRB- TNFRSF8 -RRB- gene as diagnostic biomarkers of oral_lichen_planus -LRB- OLP -RRB- .
25915578	0	TNFRSF8	115,122	tumor_necrosis_factor_receptor_superfamily_member_8	62,113	TNFRSF8	tumor necrosis factor receptor superfamily member 8	943	943	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The potential of interleukin_12_receptor_beta_2 -LRB- IL12RB2 -RRB- and tumor_necrosis_factor_receptor_superfamily_member_8 -LRB- TNFRSF8 -RRB- gene as diagnostic biomarkers of oral_lichen_planus -LRB- OLP -RRB- .
11804028	0	TNFSF11	74,81	TRANCE	83,89	TNFSF11	TRANCE	117516(Tax:10116)	117516(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence that the rat osteopetrotic mutation toothless -LRB- tl -RRB- is not in the TNFSF11 -LRB- TRANCE , RANKL , ODF , OPGL -RRB- gene .
17307753	0	TNFSF13	15,22	APRIL	8,13	TNFSF13	APRIL	8741	8741	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of APRIL -LRB- TNFSF13 -RRB- polymorphisms in the susceptibility to systemic_lupus_erythematosus in Japanese .
19251437	0	TNFSF15	43,50	TL1A	52,56	TNFSF15	TL1A	9966	9966	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Effect of sodium_butyrate on lung vascular TNFSF15 -LRB- TL1A -RRB- expression : differential expression patterns in pulmonary artery and microvascular endothelial cells .
19262684	0	TNFSF15	26,33	TL1A	15,19	TNFSF15	TL1A	9966	9966	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	IBD-associated TL1A gene -LRB- TNFSF15 -RRB- haplotypes determine increased expression of TL1A protein .
21264313	0	TNFSF15	19,26	TL1A	13,17	TNFSF15	TL1A	326623(Tax:10090)	326623(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Constitutive TL1A -LRB- TNFSF15 -RRB- expression on lymphoid or myeloid cells leads to mild intestinal_inflammation and fibrosis .
23638306	0	TNFSF15	16,23	TL1A	10,14	TNFSF15	TL1A	326623(Tax:10090)	326623(Tax:10090)	Gene	Gene	EXPRESSION|appos|START_ENTITY EXPRESSION|compound|END_ENTITY	SUSTAINED TL1A -LRB- TNFSF15 -RRB- EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS .
17349692	0	TNFSF15	69,76	tumor_necrosis_factor_superfamily_15	31,67	TNFSF15	tumor necrosis factor superfamily 15	417247(Tax:9031)	417247(Tax:9031)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of tumor_necrosis_factor_superfamily_15 -LRB- TNFSF15 -RRB- induced by lipopolysaccharides and Eimeria infection .
19778912	0	TNFSF4	15,21	OX40L	23,28	TNFSF4	OX40L	7292	7292	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of TNFSF4 -LRB- OX40L -RRB- polymorphisms with susceptibility to systemic_sclerosis .
18562480	0	TNF_R1	82,88	IRAK-1	34,40	TNF R1	IRAK-1	7132	3654	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|recruitment recruitment|nmod|END_ENTITY	Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF_R1 .
24600451	0	TNF_Receptor-Associated_Factor_1	0,32	TWEAK	62,67	TNF Receptor-Associated Factor 1	TWEAK	7185	8742	Gene	Gene	Target|nsubj|START_ENTITY Target|nmod|END_ENTITY	TNF_Receptor-Associated_Factor_1 is a Major Target of Soluble TWEAK .
24151609	0	TNF_a	0,5	IL-6	15,19	TNF a	IL-6	7124	3569	Gene	Gene	mediated|nsubj|START_ENTITY mediated|ccomp|regulated regulated|nsubjpass|secretion secretion|compound|END_ENTITY	TNF_a mediated IL-6 secretion is regulated by JAK/STAT pathway but not by MEK phosphorylation and AKT phosphorylation in U266 multiple_myeloma cells .
24961464	0	TNF_a	10,15	IL-6	17,21	TNF a	IL-6	7124	3569	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Increased TNF_a , IL-6 and ErbB2 mRNA expression in peripheral blood leukocytes from breast_cancer patients .
20649096	0	TNF_alpha	47,56	AMPK	58,62	TNF alpha	AMPK	7124	5562	Gene	Gene	Pro-insulin|appos|START_ENTITY Pro-insulin|appos|END_ENTITY	Pro-insulin , _ C_peptide , glucagon , adiponectin , TNF_alpha , AMPK : neglected players in type_2_diabetes_mellitus .
8760823	0	TNF_alpha	136,145	CD34	0,4	TNF alpha	CD34	7124	947	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	CD34 + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF_alpha .
9286332	0	TNF_alpha	136,145	CD34	0,4	TNF alpha	CD34	7124	947	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	CD34 + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF + TNF_alpha .
10891891	0	TNF_alpha	108,117	CD_20	32,37	TNF alpha	CD 20	7124	54474	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Tumor_necrosis_factor modulates CD_20 expression on cells from chronic_lymphocytic_leukemia : a new role for TNF_alpha ?
8552986	0	TNF_alpha	147,156	GM-CSF	165,171	TNF alpha	GM-CSF	7124	1437	Gene	Gene	G-CSF|appos|START_ENTITY erythrocytes|dep|G-CSF Adhesion|nmod|erythrocytes END_ENTITY|nsubj|Adhesion	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
10190115	0	TNF_alpha	77,86	Granulocyte-macrophage_colony_stimulating_factor	0,48	TNF alpha	Granulocyte-macrophage colony stimulating factor	7124	1437	Gene	Gene	production|nmod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Granulocyte-macrophage_colony_stimulating_factor modulates the production of TNF_alpha by differentiated U937 cells infected with Leishmania_major .
1327178	0	TNF_alpha	93,102	IFN_alpha	103,112	TNF alpha	IFN alpha	7124	3440	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Relation between leukocyte counts and cortisol secretion in CML patients undergoing combined TNF_alpha / IFN_alpha therapy .
10404391	0	TNF_alpha	130,139	IFN_gamma	86,95	TNF alpha	IFN gamma	24835(Tax:10116)	25712(Tax:10116)	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	Induction of transcription factor interferon_regulatory_factor-1 by interferon-gamma -LRB- IFN_gamma -RRB- and tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- in FRTL-5 cells .
1898611	0	TNF_alpha	11,20	IFN_gamma	91,100	TNF alpha	IFN gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|molecules molecules|nmod|macrophages macrophages|acl|induced induced|nmod|END_ENTITY	Effects of TNF_alpha on the expression of class II MHC molecules in macrophages induced by IFN_gamma : evidence for suppression at the level of transcription .
9174546	0	TNF_alpha	61,70	IFN_gamma	71,80	TNF alpha	IFN gamma	7124	3458	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Thrombocytopenia and complement activation under recombinant TNF_alpha / IFN_gamma therapy in man .
1893406	0	TNF_alpha	24,33	IL-1	35,39	TNF alpha	IL-1	21926(Tax:10090)	111343(Tax:10090)	Gene	Gene	IL-6|compound|START_ENTITY IL-6|dep|END_ENTITY	Induction of macrophage TNF_alpha , IL-1 , IL-6 , and PGE2 production by DTH-initiating factors .
1993554	0	TNF_alpha	254,263	IL-1	221,225	TNF alpha	IL-1	7124	3552	Gene	Gene	interleukin-1|appos|START_ENTITY interleukin-1|appos|END_ENTITY	Growth regulation of the AML-193 leukemic cell line : evidence for autocrine production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , and inhibition of GM-CSF-dependent cell proliferation by interleukin-1 -LRB- IL-1 -RRB- and tumor necrosis factor -LRB- TNF_alpha -RRB- .
8552986	0	TNF_alpha	147,156	IL-1-beta	99,108	TNF alpha	IL-1-beta	7124	3553	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|compound|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
12616343	0	TNF_alpha	176,185	IL-10	213,218	TNF alpha	IL-10	7124	3586	Gene	Gene	suppression|nmod|START_ENTITY blockage|nsubj|suppression blockage|nmod|END_ENTITY	IL-18 initiates release of matrix_metalloproteinase-9 from peripheral blood mononuclear cells without affecting tissue inhibitor of matrix metalloproteinases-1 : suppression by TNF_alpha blockage and modulation by IL-10 .
8552986	0	TNF_alpha	147,156	IL-10	130,135	TNF alpha	IL-10	7124	3586	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8552986	0	TNF_alpha	147,156	IL-1RA	110,116	TNF alpha	IL-1RA	7124	3557	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
10769674	0	TNF_alpha	0,9	IL-1_beta	11,20	TNF alpha	IL-1 beta	7124	3553	Gene	Gene	START_ENTITY|appos|production production|amod|END_ENTITY	TNF_alpha , IL-1_beta and IL-6 production by peripheral blood monocytes in patients with renal_cell_carcinoma .
11243098	0	TNF_alpha	14,23	IL-1_beta	25,34	TNF alpha	IL-1 beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
11243098	0	TNF_alpha	58,67	IL-1_beta	25,34	TNF alpha	IL-1 beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY Expression|appos|release Expression|appos|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
7531179	0	TNF_alpha	0,9	IL-1_beta	11,20	TNF alpha	IL-1 beta	7124	3553	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	TNF_alpha , IL-1_beta and IL-6 plasma levels in neutropenic patients after onset of fever and correlation with the C-reactive_protein -LRB- CRP -RRB- kinetic values .
8758268	0	TNF_alpha	13,22	IL-1_beta	24,33	TNF alpha	IL-1 beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY -LSB-|dobj|role -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The role of TNF_alpha , IL-1_beta and MIP-1_alpha in LPS-induced organ injury -RSB- .
11243098	0	TNF_alpha	14,23	IL-6	36,40	TNF alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|mRNA mRNA|compound|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
11243098	0	TNF_alpha	58,67	IL-6	36,40	TNF alpha	IL-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY Expression|appos|release Expression|appos|mRNA mRNA|compound|END_ENTITY	Expression of TNF_alpha , IL-1_beta , IL-6 mRNA , release of TNF_alpha in vital organs and their relationship with endotoxin translocation following hemorrhagic_shock .
1504836	0	TNF_alpha	0,9	IL-6	18,22	TNF alpha	IL-6	7124	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	TNF_alpha induces IL-6 production by astrocytes but not by microglia .
2067355	0	TNF_alpha	68,77	IL-6	10,14	TNF alpha	IL-6	7124	3569	Gene	Gene	doses|nmod|START_ENTITY fibroblasts|nmod|doses secretion|nmod|fibroblasts END_ENTITY|acl|secretion	Decreased IL-6 secretion by fibroblasts following repeated doses of TNF_alpha or IL-1_alpha : post-transcriptional gene regulation .
7949797	0	TNF_alpha	66,75	IL-6	96,100	TNF alpha	IL-6	7124	3569	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY tumor_necrosis_factor_alpha|appos|END_ENTITY	Diagnostic value of plasma levels of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- and interleukin-6 -LRB- IL-6 -RRB- in newborns with sepsis .
8370344	0	TNF_alpha	46,55	IL-6	57,61	TNF alpha	IL-6	7124	3569	Gene	Gene	IL-1_beta|dep|START_ENTITY IL-1_beta|dep|END_ENTITY	Effect of pentamidine on cytokine -LRB- IL-1_beta , TNF_alpha , IL-6 -RRB- production by human alveolar macrophages in vitro .
8552986	0	TNF_alpha	147,156	IL-6	118,122	TNF alpha	IL-6	7124	3569	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
12585121	0	TNF_alpha	91,100	IL-8	42,46	TNF alpha	IL-8	7124	3576	Gene	Gene	induced|nmod|START_ENTITY production|acl|induced production|compound|END_ENTITY	-LSB- Inhibitory effects of isorhapotigenin on IL-8 production and mRNA expression induced with TNF_alpha in normal human synovial cells -RSB- .
8552986	0	TNF_alpha	147,156	IL-8	124,128	TNF alpha	IL-8	7124	3576	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
8574751	0	TNF_alpha	96,105	IL-8	9,13	TNF alpha	IL-8	7124	3576	Gene	Gene	secretion|nmod|START_ENTITY associated|nmod|secretion associated|nsubjpass|production production|compound|END_ENTITY	Elevated IL-8 production by trauma patients ' monocytes is associated with elevated secretion of TNF_alpha .
9427069	0	TNF_alpha	31,40	IL-8	0,4	TNF alpha	IL-8	100009088(Tax:9986)	100009129(Tax:9986)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	IL-8 is involved in homologous TNF_alpha - , but not in IL-1_beta-induced neutrophil infiltration in rabbits .
1953054	0	TNF_alpha	46,55	IL_2	76,80	TNF alpha	IL 2	7124	3558	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY tumor_necrosis_factor_alpha|appos|END_ENTITY	Determination of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- and interleukin_2 -LRB- IL_2 -RRB- in women with idiopathic_recurrent_miscarriage .
24794530	0	TNF_alpha	132,141	Metaxins_1_and_2	0,16	TNF alpha	Metaxins 1 and 2	7124	4580;10651	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Metaxins_1_and_2 , two proteins of the mitochondrial protein sorting and assembly machinery , are essential for Bak activation during TNF_alpha triggered apoptosis .
12506026	0	TNF_alpha	98,107	PAI-1	117,122	TNF alpha	PAI-1	7124	5054	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|compound|END_ENTITY	Direct binding of Nur77/NAK -1 to the plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- promoter regulates TNF_alpha - induced PAI-1 expression .
10606930	0	TNF_alpha	25,34	RANTES	65,71	TNF alpha	RANTES	7124	6352	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	p38_MAP_kinase regulates TNF_alpha - , IL-1_alpha - and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells .
7505037	0	TNF_alpha	0,9	RANTES	61,67	TNF alpha	RANTES	21926(Tax:10090)	20304(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	TNF_alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells .
17963605	0	TNF_alpha	12,21	SCAP	43,47	TNF alpha	SCAP	7124	22937	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of TNF_alpha on the expression of SCAP and triglyceride contents in cultured steatotic hepatocytes -RSB- .
8552986	0	TNF_alpha	147,156	TGF_beta	137,145	TNF alpha	TGF beta	7124	7040	Gene	Gene	G-CSF|appos|START_ENTITY G-CSF|appos|END_ENTITY	Adhesion of Plasmodium_falciparum-infected erythrocytes to human cells and secretion of cytokines -LRB- IL-1-beta , IL-1RA , IL-6 , IL-8 , IL-10 , TGF_beta , TNF_alpha , G-CSF , GM-CSF .
16480927	0	TNF_alpha	0,9	TLR2	24,28	TNF alpha	TLR2	7124	7097	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	TNF_alpha production to TLR2 ligands in active IBD patients .
12888880	0	TNF_alpha	82,91	TNF_alpha	9,18	TNF alpha	TNF alpha	7124	7124	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Enhanced TNF_alpha and oxidative stress in patients with heart_failure : effect of TNF_alpha on platelet O2 - production .
12888880	0	TNF_alpha	9,18	TNF_alpha	82,91	TNF alpha	TNF alpha	7124	7124	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Enhanced TNF_alpha and oxidative stress in patients with heart_failure : effect of TNF_alpha on platelet O2 - production .
7794042	0	TNF_alpha	128,137	TNF_alpha	8,17	TNF alpha	TNF alpha	100009088(Tax:9986)	100009088(Tax:9986)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of TNF_alpha in the induction of antigen_induced_arthritis in the rabbit and the anti-arthritic effect of species specific TNF_alpha neutralising monoclonal antibodies .
7794042	0	TNF_alpha	8,17	TNF_alpha	128,137	TNF alpha	TNF alpha	100009088(Tax:9986)	100009088(Tax:9986)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of TNF_alpha in the induction of antigen_induced_arthritis in the rabbit and the anti-arthritic effect of species specific TNF_alpha neutralising monoclonal antibodies .
8275935	0	TNF_alpha	43,52	TNF_alpha	88,97	TNF alpha	TNF alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Expression of tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- receptors and selective effect of TNF_alpha on the inner cell mass in mouse blastocysts .
8275935	0	TNF_alpha	88,97	TNF_alpha	43,52	TNF alpha	TNF alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Expression of tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- receptors and selective effect of TNF_alpha on the inner cell mass in mouse blastocysts .
10891891	0	TNF_alpha	108,117	Tumor_necrosis_factor	0,21	TNF alpha	Tumor necrosis factor	7124	7124	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Tumor_necrosis_factor modulates CD_20 expression on cells from chronic_lymphocytic_leukemia : a new role for TNF_alpha ?
7674090	0	TNF_alpha	76,85	VWF	0,3	TNF alpha	VWF	7124	7450	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	VWF release and platelet_aggregation in human melanoma after perfusion with TNF_alpha .
20649096	0	TNF_alpha	47,56	adiponectin	34,45	TNF alpha	adiponectin	7124	9370	Gene	Gene	Pro-insulin|appos|START_ENTITY Pro-insulin|appos|END_ENTITY	Pro-insulin , _ C_peptide , glucagon , adiponectin , TNF_alpha , AMPK : neglected players in type_2_diabetes_mellitus .
2439155	0	TNF_alpha	18,27	granulocyte_colony-stimulating_factor	53,90	TNF alpha	granulocyte colony-stimulating factor	7124	1440	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Recombinant human TNF_alpha stimulates production of granulocyte_colony-stimulating_factor .
8438219	0	TNF_alpha	39,48	interleukin_1	51,64	TNF alpha	interleukin 1	7124	3552	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY tumor_necrosis_factor_alpha|appos|END_ENTITY	Increased tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- , interleukin_1 , and interleukin_6 -LRB- IL-6 -RRB- levels in the plasma of stored platelet concentrates : relationship between TNF_alpha and IL-6 levels and febrile transfusion reactions .
7514902	0	TNF_alpha	53,62	p55	155,158	TNF alpha	p55	7124	3559	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY effects|nmod|tumor_necrosis_factor_alpha effects|dep|involvement involvement|nmod|receptors receptors|amod|END_ENTITY	Bifunctional effects of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- on the growth of mature and primitive human hematopoietic progenitor cells : involvement of p55 and p75 TNF receptors .
7522632	0	TNF_alpha	151,160	p55	147,150	TNF alpha	p55	7124	7132	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
7522632	0	TNF_alpha	29,38	p55	147,150	TNF alpha	p55	7124	7132	Gene	Gene	Tumor_necrosis_factor_alpha|appos|START_ENTITY downregulates|nsubj|Tumor_necrosis_factor_alpha downregulates|dobj|expression expression|nmod|cells cells|nmod|receptors receptors|amod|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
8235292	0	TNF_alpha	33,42	p55	54,57	TNF alpha	p55	7124	7132	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Studies on the expression of the TNF_alpha receptors -LRB- p55 and p75 -RRB- and their relative contributions to prostanoid production and glycolytic rate by rheumatoid synovial fibroblasts in vitro .
8275935	0	TNF_alpha	88,97	tumor_necrosis_factor-alpha	14,41	TNF alpha	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Expression of tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- receptors and selective effect of TNF_alpha on the inner cell mass in mouse blastocysts .
8837058	0	TNF_alpha	63,72	tumor_necrosis_factor-alpha	34,61	TNF alpha	tumor necrosis factor-alpha	100009088(Tax:9986)	100009088(Tax:9986)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Preliminary morphometric study of tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- - induced rabbit optic_neuropathy .
10403560	0	TNF_alpha	44,53	tumor_necrosis_factor_alpha	15,42	TNF alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- with high Caspase_3-like activity in myelodysplastic_syndromes .
7575990	0	TNF_alpha	73,82	tumor_necrosis_factor_alpha	44,71	TNF alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	association|appos|START_ENTITY association|amod|END_ENTITY	Effects of interferon_gamma -LRB- IFN_gamma -RRB- and tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- association in intraperitoneal radioimmunotherapy : studies on an in vitro micrometastasis model .
8832970	0	TNF_alpha	46,55	tumor_necrosis_factor_alpha	17,44	TNF alpha	tumor necrosis factor alpha	7124	7124	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Relevance of the tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- -308 promoter polymorphism in TNF_alpha gene regulation .
17525194	0	TNF_and_IL-1	13,25	matrix_metalloproteinase-3	46,72	TNF and IL-1	matrix metalloproteinase-3	7124;3552	4314	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Synergism of TNF_and_IL-1 in the induction of matrix_metalloproteinase-3 in trabecular meshwork .
10566598	0	TNF_microsatellite_polymorphisms	13,45	TNFa	47,51	TNF microsatellite polymorphisms	TNFa	7124	7124	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of TNF_microsatellite_polymorphisms -LRB- TNFa -RRB- on age-at-onset of insulin-dependent_diabetes_mellitus .
10200474	0	TNF_or_anti-Fas	63,78	CPP32	34,39	TNF or anti-Fas	CPP32	7124	836	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Wortmannin enhances activation of CPP32 -LRB- Caspase-3 -RRB- induced by TNF_or_anti-Fas .
10666158	0	TNF_receptor	76,88	leptin	42,48	TNF receptor	leptin	21937(Tax:10090)	16846(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Tumor_necrosis_factor _ -LRB- TNF -RRB- - alpha induces leptin production through the p55 TNF_receptor .
10201981	0	TNF_receptor-associated_factor-2	0,32	IL-1_beta	53,62	TNF receptor-associated factor-2	IL-1 beta	7186	3553	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	TNF_receptor-associated_factor-2 is involved in both IL-1_beta and TNF-alpha signaling cascades leading to NF-kappa_B activation and IL-8 expression in human intestinal epithelial cells .
11418661	0	TNF_receptor-associated_factor-6	70,102	IL-1	0,4	TNF receptor-associated factor-6	IL-1	222344	3552	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	IL-1 induced chemokine production through the association of Syk with TNF_receptor-associated_factor-6 in nasal fibroblast lines .
9379019	0	TNF_receptor-associated_factor_2	45,77	CD40	85,89	TNF receptor-associated factor 2	CD40	7186	958	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	CD40-mediated signals inhibit the binding of TNF_receptor-associated_factor_2 to the CD40 cytoplasmic domain .
22042853	0	TNF_receptor-associated_factor_2	17,49	TRAF2	51,56	TNF receptor-associated factor 2	TRAF2	22030(Tax:10090)	22030(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Crucial role for TNF_receptor-associated_factor_2 -LRB- TRAF2 -RRB- in regulating NFkB2 signaling that contributes to autoimmunity .
10477597	0	TNF_receptor-associated_factor_2	72,104	germinal_center_kinase_related	128,158	TNF receptor-associated factor 2	germinal center kinase related	7186	11183	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|END_ENTITY	TNF-mediated activation of the stress-activated protein kinase pathway : TNF_receptor-associated_factor_2 recruits and activates germinal_center_kinase_related .
16393988	0	TNF_receptor-associated_factor_6	15,47	IL-25	51,56	TNF receptor-associated factor 6	IL-25	22034(Tax:10090)	140806(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Involvement of TNF_receptor-associated_factor_6 in IL-25 receptor signaling .
18056395	0	TNF_receptor-associated_factor_6	25,57	IL-8	132,136	TNF receptor-associated factor 6	IL-8	222344	3576	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Caspase-4 interacts with TNF_receptor-associated_factor_6 and mediates lipopolysaccharide-induced NF-kappaB-dependent production of IL-8 and CC chemokine ligand 4 -LRB- macrophage-inflammatory protein-1 -RRB- .
26807171	0	TNF_receptor-associated_factor_6	0,32	TGF-b	88,93	TNF receptor-associated factor 6	TGF-b	311245(Tax:10116)	59086(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	TNF_receptor-associated_factor_6 -LRB- TRAF6 -RRB- mediates the angiotensin-induced non-canonical TGF-b pathway activation of c-kit -LRB- + -RRB- cardiac stem cells .
12644782	0	TNF_receptor_1	166,180	TNFR1	182,187	TNF receptor 1	TNFR1	7132	7132	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hereditary , familial , and idiopathic_chronic_pancreatitis are not associated with polymorphisms in the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- promoter region or the TNF_receptor_1 -LRB- TNFR1 -RRB- gene .
10504438	0	TNF_receptor_II	84,99	IL-4	0,4	TNF receptor II	IL-4	7133	3565	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression inhibits|nmod|downregulation inhibits|nsubj|END_ENTITY	IL-4 inhibits the migration of human Langerhans cells through the downregulation of TNF_receptor_II expression .
9531303	0	TNF_receptor_type_1	16,35	TNF_receptor_type_2	54,73	TNF receptor type 1	TNF receptor type 2	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
9531303	0	TNF_receptor_type_1	16,35	p55	37,40	TNF receptor type 1	p55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
9531303	0	TNF_receptor_type_2	54,73	TNF_receptor_type_1	16,35	TNF receptor type 2	TNF receptor type 1	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
9531303	0	TNF_receptor_type_2	54,73	p55	37,40	TNF receptor type 2	p55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
22018416	0	TNFa	17,21	ADAM17	0,6	TNFa	ADAM17	7124	6868	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	ADAM17 regulates TNFa production by placental trophoblasts .
23469174	0	TNFa	14,18	Akt	0,3	TNFa	Akt	21926(Tax:10090)	11651(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|compound|END_ENTITY	Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis .
22024156	0	TNFa	89,93	C/EBPa	0,6	TNFa	C/EBPa	7124	1050	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	C/EBPa mediates the transcriptional suppression of human calreticulin gene expression by TNFa .
22699883	0	TNFa	0,4	CD40	35,39	TNFa	CD40	7124	958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	TNFa regulates the localization of CD40 in lipid rafts of glioma cells .
26065428	0	TNFa	0,4	DNaseI	15,21	TNFa	DNaseI	7124	13419(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TNFa Amplifies DNaseI Expression in Renal Tubular Cells while IL-1b Promotes Nuclear DNaseI Translocation in an Endonuclease-Inactive Form .
23613863	0	TNFa	0,4	Fibroblast_Growth_Factor_Receptor_2	15,50	TNFa	Fibroblast Growth Factor Receptor 2	7124	2263	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	TNFa modulates Fibroblast_Growth_Factor_Receptor_2 gene expression through the pRB/E2F1 pathway : identification of a non-canonical E2F binding motif .
21884837	0	TNFa	0,4	GM-CSF	72,78	TNFa	GM-CSF	7124	1437	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	TNFa inhibits the development of osteoclasts through osteoblast-derived GM-CSF .
25584775	0	TNFa	107,111	Granulocyte-colony_stimulating_factor	0,37	TNFa	Granulocyte-colony stimulating factor	21926(Tax:10090)	12985(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|dep|Role	Granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- - induced mechanical_hyperalgesia in mice : Role for peripheral TNFa , IL-1b and IL-10 .
24816983	0	TNFa	57,61	IL-10	84,89	TNFa	IL-10	7124	3586	Gene	Gene	mediators|nmod|START_ENTITY Regulation|nmod|mediators Regulation|dep|effects effects|nmod|overexpression overexpression|compound|END_ENTITY	Regulation of osteoarthritis-associated key mediators by TNFa and IL-10 : effects of IL-10 overexpression in human synovial fibroblasts and a synovial cell line .
25384561	0	TNFa	10,14	IL-10	4,9	TNFa	IL-10	7124	3586	Gene	Gene	Ratio|compound|START_ENTITY END_ENTITY|dep|Ratio	Low IL-10 / TNFa Ratio in Patients with Coronary_Artery_Disease and Reduced Left Ventricular Ejection Fraction with a Poor Prognosis After 10 Years .
21092452	0	TNFa	34,38	IL-1b	27,32	TNFa	IL-1b	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|expression expression|nmod|END_ENTITY	-LSB- The expression of mucosal IL-1b , TNFa and serotonin_transporter in chronic visceral_hypersensitivity rats -RSB- .
20595711	0	TNFa	12,16	IL-6	6,10	TNFa	IL-6	7124	100548599	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Serum IL-6 , TNFa levels in snakebite cases occurring in Southern Turkey .
23675187	0	TNFa	18,22	IL-6	0,4	TNFa	IL-6	7124	3569	Gene	Gene	Induction|nmod|START_ENTITY Induction|compound|END_ENTITY	IL-6 Induction by TNFa and IL-1b in an Osteoblast-Like Cell Line .
25436214	0	TNFa	0,4	IL-6	48,52	TNFa	IL-6	7124	3569	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	TNFa promotes Th17 cell differentiation through IL-6 and IL-1b produced by monocytes in rheumatoid_arthritis .
22525504	0	TNFa	1,5	IL-8	14,18	TNFa	IL-8	7124	3576	Gene	Gene	START_ENTITY|acl|induced induced|dobj|production production|compound|END_ENTITY	-LSB- TNFa induced IL-8 production through p38 MAPK - NF-kB pathway in human hepatocellular_carcinoma cells -RSB- .
25443723	0	TNFa	36,40	Il-2	24,28	TNFa	Il-2	7124	3558	Gene	Gene	Il-1b|appos|START_ENTITY Il-1b|appos|END_ENTITY	Concentration of Il-1b , Il-2 , Il-6 , TNFa in the blood serum in children with generalized_epilepsy treated by valproate .
25443723	0	TNFa	36,40	Il-6	30,34	TNFa	Il-6	7124	3569	Gene	Gene	Il-1b|appos|START_ENTITY Il-1b|appos|END_ENTITY	Concentration of Il-1b , Il-2 , Il-6 , TNFa in the blood serum in children with generalized_epilepsy treated by valproate .
26644407	0	TNFa	22,26	LARP4	0,5	TNFa	LARP4	7124	113251	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	LARP4 is regulated by TNFa in a Tristetraprolin -LRB- TTP -RRB- - dependent manner .
22166493	0	TNFa	0,4	PTP1B	28,33	TNFa	PTP1B	24835(Tax:10116)	24697(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	TNFa increases hypothalamic PTP1B activity via the NFkB pathway in rat hypothalamic organotypic cultures .
21809123	0	TNFa	63,67	Pyruvate_dehydrogenase	0,22	TNFa	Pyruvate dehydrogenase	7124	54704	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Pyruvate_dehydrogenase inhibition by the inflammatory cytokine TNFa contributes to the pathogenesis of pulmonary_arterial_hypertension .
26798197	0	TNFa	39,43	RANKL	61,66	TNFa	RANKL	24835(Tax:10116)	117516(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Dietary zinc supplementation increased TNFa and IL1b-induced RANKL expression , resulting in a decrease in bone mineral density in rats .
23469174	0	TNFa	14,18	RIP1	43,47	TNFa	RIP1	21926(Tax:10090)	19766(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Akt Regulates TNFa synthesis downstream of RIP1 kinase activation during necroptosis .
24086429	0	TNFa	32,36	RhoB	17,21	TNFa	RhoB	7124	388	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The small GTPase RhoB regulates TNFa signaling in endothelial cells .
23800059	0	TNFa	0,4	S100A8	26,32	TNFa	S100A8	7124	6279	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNFa - and IL-17A-mediated S100A8 expression is regulated by p38 MAPK .
25770475	0	TNFa	0,4	SIRT1	15,20	TNFa	SIRT1	21926(Tax:10090)	93759(Tax:10090)	Gene	Gene	Cleavage|compound|START_ENTITY Cleavage|compound|END_ENTITY	TNFa Regulates SIRT1 Cleavage during Ocular Autoimmune_Disease .
25072865	0	TNFa	61,65	SLC25A1	49,56	TNFa	SLC25A1	7124	6576	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A key role of the mitochondrial citrate carrier -LRB- SLC25A1 -RRB- in TNFa - and IFNy-triggered inflammation .
24371310	0	TNFa	39,43	THRIL	23,28	TNFa	THRIL	7124	102659353	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The long noncoding RNA THRIL regulates TNFa expression through its interaction with hnRNPL .
22450316	0	TNFa	0,4	TLR4	36,40	TNFa	TLR4	7124	7099	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	TNFa and IL-1b are mediated by both TLR4 and Nod1 pathways in the cultured HAPI cells stimulated by LPS .
23487197	0	TNFa	74,78	TNF-alpha	63,72	TNFa	TNF-alpha	7124	7124	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of interleukin_2 -LRB- IL-2 -RRB- , interleukin_6 -LRB- IL-6 -RRB- , and TNF-alpha -LRB- TNFa -RRB- gene polymorphisms with paranoid schizophrenia in a Polish population .
10566598	0	TNFa	47,51	TNF_microsatellite_polymorphisms	13,45	TNFa	TNF microsatellite polymorphisms	7124	7124	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of TNF_microsatellite_polymorphisms -LRB- TNFa -RRB- on age-at-onset of insulin-dependent_diabetes_mellitus .
26689461	0	TNFa	10,14	TNFa	62,66	TNFa	TNFa	7124	7124	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Silencing TNFa with lipidoid nanoparticles downregulates both TNFa and MCP-1 in an in vitro co-culture model of diabetic_foot_ulcers .
26689461	0	TNFa	62,66	TNFa	10,14	TNFa	TNFa	7124	7124	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Silencing TNFa with lipidoid nanoparticles downregulates both TNFa and MCP-1 in an in vitro co-culture model of diabetic_foot_ulcers .
21628460	0	TNFa	58,62	TRIM32	0,6	TNFa	TRIM32	7124	22954	Gene	Gene	cells|appos|START_ENTITY cells|nummod|END_ENTITY	TRIM32 protein sensitizes cells to tumor_necrosis_factor -LRB- TNFa -RRB- - induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- .
23411401	0	TNFa	42,46	TRPV1	23,28	TNFa	TRPV1	7124	7442	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Thermal stimulation of TRPV1 up-regulates TNFa expression in human periodontal ligament cells .
26644407	0	TNFa	22,26	Tristetraprolin	32,47	TNFa	Tristetraprolin	7124	7538	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	LARP4 is regulated by TNFa in a Tristetraprolin -LRB- TTP -RRB- - dependent manner .
26618585	0	TNFa	29,33	Tumor_necrosis_factor-alpha	0,27	TNFa	Tumor necrosis factor-alpha	280943(Tax:9913)	280943(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNFa -RRB- gene polymorphism and expression of membrane-bound TNFa protein on CD11b + and IgM + cells in cows naturally infected_with_bovine_leukemia_virus .
25808614	0	TNFa	0,4	ZnT2	34,38	TNFa	ZnT2	7124	7780	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	TNFa post-translationally targets ZnT2 to accumulate zinc in lysosomes .
22770519	0	TNFa	29,33	mCD14	14,19	TNFa	mCD14	21926(Tax:10090)	12475(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Inhibition of mCD14 inhibits TNFa secretion and NO production in RAW264 .7 cells stimulated by Brucella_melitensis_infection .
22375552	0	TNFa	63,67	p110	37,41	TNFa	p110	7124	100616443	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Isoform-selective induction of human p110 PI3K expression by TNFa : identification of a new and inducible PIK3CD promoter .
24349153	0	TNFa	0,4	p66	17,20	TNFa	p66	7124	10714	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	TNFa signals via p66 -LRB- Shc -RRB- to induce E-Selectin , promote leukocyte transmigration and enhance permeability in human endothelial cells .
20801629	0	TNFa	33,37	tumor_necrosis_factor_a	8,31	TNFa	tumor necrosis factor a	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of tumor_necrosis_factor_a -LRB- TNFa -RRB- in the onset of fructose-induced nonalcoholic_fatty_liver_disease in mice .
21030411	0	TNFa	34,38	tumour_necrosis_factor-a	8,32	TNFa	tumour necrosis factor-a	280943(Tax:9913)	280943(Tax:9913)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of tumour_necrosis_factor-a -LRB- TNFa -RRB- in the functional properties of hyalocytes .
22374443	0	TNFa-induced_adipose-related_protein	17,53	TIARP	55,60	TNFa-induced adipose-related protein	TIARP	79689	79689	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	-LSB- Crucial role of TNFa-induced_adipose-related_protein -LRB- TIARP -RRB- in the pathogenesis of autoimmune_arthritis -RSB- .
16492740	0	TNFalpha	0,8	ABCA1	17,22	TNFalpha	ABCA1	7124	19	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells .
15792609	0	TNFalpha	0,8	Akt	39,42	TNFalpha	Akt	7124	207	Gene	Gene	played|nsubj|START_ENTITY played|nmod|induction induction|nmod|signals signals|compound|END_ENTITY	TNFalpha played a role in induction of Akt and MAPK signals in ameloblastoma .
16140562	0	TNFalpha	58,66	Akt	14,17	TNFalpha	Akt	7124	207	Gene	Gene	potential|nmod|START_ENTITY elevated|dobj|potential elevated|nsubj|Inhibition Inhibition|nmod|pathways pathways|compound|END_ENTITY	Inhibition of Akt and MAPK pathways elevated potential of TNFalpha in inducing apoptosis in ameloblastoma .
19836430	0	TNFalpha	0,8	Akt	44,47	TNFalpha	Akt	7124	207	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	TNFalpha induced oxidative stress dependent Akt signaling affects actin cytoskeletal organization in glioma cells .
10549624	0	TNFalpha	67,75	B7h	0,3	TNFalpha	B7h	21926(Tax:10090)	50723(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	B7h , a novel costimulatory homolog of B7 .1 _ and_B7 .2 , is induced by TNFalpha .
19302817	0	TNFalpha	0,8	CCL1	61,65	TNFalpha	CCL1	7124	6346	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	TNFalpha - and NF-kappaB-dependent induction of the chemokine CCL1 in human macrophages exposed to the atherogenic lipoprotein -LRB- a -RRB- .
14676780	0	TNFalpha	14,22	CD3	26,29	TNFalpha	CD3	21926(Tax:10090)	12501(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|+ +|compound|END_ENTITY	Expression of TNFalpha by CD3 + and F4/80 + cells following irradiation preconditioning and allogeneic spleen cell transplantation .
11571353	0	TNFalpha	0,8	CD4	23,26	TNFalpha	CD4	7124	920	Gene	Gene	production|compound|START_ENTITY production|nmod|T T|compound|END_ENTITY	TNFalpha production by CD4 -LRB- + -RRB- T cells predicts long-term increase in lesion load on MRI in MS. Reliable laboratory prognostic factors for MS are still lacking .
14592548	0	TNFalpha	0,8	COX-2	25,30	TNFalpha	COX-2	24835(Tax:10116)	26198(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TNFalpha regulates renal COX-2 in the rat thick ascending limb -LRB- TAL -RRB- .
20303596	0	TNFalpha	30,38	CREB	8,12	TNFalpha	CREB	7124	1385	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264 .7 macrophages .
15561766	0	TNFalpha	0,8	Cdc42	42,47	TNFalpha	Cdc42	21926(Tax:10090)	12540(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	TNFalpha induces sequential activation of Cdc42 - and p38/p53-dependent pathways that antagonistically regulate filopodia formation .
11549697	0	TNFalpha	0,8	Fas_ligand	28,38	TNFalpha	Fas ligand	7124	356	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	TNFalpha down-regulates the Fas_ligand and inhibits germ cell apoptosis in the human testis .
9546786	0	TNFalpha	0,8	Fas_ligand	23,33	TNFalpha	Fas ligand	7124	356	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	TNFalpha regulation of Fas_ligand expression on the vascular endothelium modulates leukocyte extravasation .
9594023	0	TNFalpha	47,55	Granulocyte-colony_stimulating_factor	0,37	TNFalpha	Granulocyte-colony stimulating factor	7124	1440	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Granulocyte-colony_stimulating_factor inhibits TNFalpha production in a human hepatoma cell line .
17451682	0	TNFalpha	107,115	HIF-1alpha	0,10	TNFalpha	HIF-1alpha	7124	3091	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|expression expression|amod|END_ENTITY	HIF-1alpha expression in response to lipopolysaccaride mediates induction of hepatic inflammatory cytokine TNFalpha .
19766100	0	TNFalpha	0,8	HIF-1alpha	17,27	TNFalpha	HIF-1alpha	7124	3091	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TNFalpha induces HIF-1alpha expression through activation of IKKbeta .
11160917	0	TNFalpha	130,138	HuR	123,126	TNFalpha	HuR	21926(Tax:10090)	15568(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY END_ENTITY|nmod|mRNA	Polymorphism in the 3 ' - untranslated region of TNFalpha mRNA impairs binding of the post-transcriptional regulatory protein HuR to TNFalpha mRNA .
12876290	0	TNFalpha	61,69	HuR	50,53	TNFalpha	HuR	24835(Tax:10116)	363854(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Chronic ethanol exposure increases the binding of HuR to the TNFalpha 3 ' - untranslated region in macrophages .
14572618	0	TNFalpha	11,19	ICAM-1	37,43	TNFalpha	ICAM-1	7124	3383	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro : oxidant-mediated pathways and transcription factors .
15480988	0	TNFalpha	0,8	ICAM-1	120,126	TNFalpha	ICAM-1	7124	3383	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|contractility contractility|nmod|induction induction|nmod|END_ENTITY	TNFalpha suppresses human colonic circular smooth muscle cell contractility by SP1 - and NF-kappaB-mediated induction of ICAM-1 .
15864742	0	TNFalpha	20,28	ICAM-1	0,6	TNFalpha	ICAM-1	7124	3383	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	ICAM-1 induction by TNFalpha and IL-6 is mediated by distinct pathways via Rac in endothelial cells .
19766100	0	TNFalpha	0,8	IKKbeta	61,68	TNFalpha	IKKbeta	7124	3551	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	TNFalpha induces HIF-1alpha expression through activation of IKKbeta .
17967442	0	TNFalpha	11,19	IL-1	66,70	TNFalpha	IL-1	21926(Tax:10090)	111343(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Peripheral TNFalpha , but not peripheral IL-1 , requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response .
15786541	0	TNFalpha	12,20	IL-6	6,10	TNFalpha	IL-6	7124	3569	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Serum IL-6 , TNFalpha and CRP levels in Greek colorectal_cancer patients : prognostic implications .
16316790	0	TNFalpha	0,8	IL-6	55,59	TNFalpha	IL-6	7124	3569	Gene	Gene	utilize|nsubj|START_ENTITY utilize|xcomp|induce induce|dobj|expression expression|compound|END_ENTITY	TNFalpha and PTH utilize distinct mechanisms to induce IL-6 and RANKL expression with markedly different kinetics .
18582534	0	TNFalpha	45,53	IL-6	32,36	TNFalpha	IL-6	7124	3569	Gene	Gene	interleukin|appos|START_ENTITY interleukin|appos|IL-2 IL-2|dep|IL-4 IL-4|dep|END_ENTITY	Serum interleukin -LRB- IL-2 , IL-10 , IL-6 , IL-4 -RRB- , TNFalpha , and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism .
20020446	0	TNFalpha	36,44	MMP-9	16,21	TNFalpha	MMP-9	7124	4318	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin_D .
10486238	0	TNFalpha	59,67	NF-kappaB	29,38	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Role of transcription factor NF-kappaB in asbestos-induced TNFalpha response from macrophages .
10644980	0	TNFalpha	29,37	NF-kappaB	47,56	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	p21Waf1/Cip1|nmod|START_ENTITY Induction|nmod|p21Waf1/Cip1 requires|nsubj|Induction requires|dobj|activity activity|amod|END_ENTITY	Induction of p21Waf1/Cip1 by TNFalpha requires NF-kappaB activity and antagonizes apoptosis in Ewing_tumor cells .
11238728	0	TNFalpha	129,137	NF-kappaB	62,71	TNFalpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY converts|dobj|effects converts|nsubj|p52 p52|compound|END_ENTITY	Inhibition of tumour necrosis factor-alpha -LRB- TNFalpha -RRB- - induced NF-kappaB p52 converts the metabolic effects of microglial-derived TNFalpha on mouse cerebellar neurones to neurotoxicity .
11238728	0	TNFalpha	44,52	NF-kappaB	62,71	TNFalpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	factor-alpha|appos|START_ENTITY necrosis|dobj|factor-alpha necrosis|parataxis|converts converts|nsubj|p52 p52|compound|END_ENTITY	Inhibition of tumour necrosis factor-alpha -LRB- TNFalpha -RRB- - induced NF-kappaB p52 converts the metabolic effects of microglial-derived TNFalpha on mouse cerebellar neurones to neurotoxicity .
11831701	0	TNFalpha	80,88	NF-kappaB	118,127	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	cells|nmod|START_ENTITY enhancer/promoter|nmod|cells Stimulation|nmod|enhancer/promoter mediated|nsubjpass|Stimulation mediated|nmod|induction induction|nmod|END_ENTITY	Stimulation of the human_cytomegalovirus IE enhancer/promoter in HL-60 cells by TNFalpha is mediated via induction of NF-kappaB .
12859994	0	TNFalpha	11,19	NF-kappaB	163,172	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	Effects|nmod|START_ENTITY progenitors|nsubj|Effects progenitors|nmod|role role|nmod|END_ENTITY	Effects of TNFalpha on the growth and sensitivity to cytosine_arabinoside of blast progenitors in acute_myelogenous_leukemia with special reference to the role of NF-kappaB .
15036249	0	TNFalpha	17,25	NF-kappaB	44,53	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Aspirin inhibits TNFalpha - and IL-1-induced NF-kappaB activation and sensitizes HeLa cells to apoptosis .
15380520	0	TNFalpha	96,104	NF-kappaB	14,23	TNFalpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY converts|parataxis|mediated converts|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of NF-kappaB in cancer cells converts inflammation - induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression .
16492740	0	TNFalpha	0,8	NF-kappaB	31,40	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells .
16933209	0	TNFalpha	37,45	NF-kappaB	112,121	TNFalpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	/|compound|START_ENTITY response|nmod|/ response|dep|role role|nmod|END_ENTITY	Differential teratogenic response of TNFalpha + / + and TNFalpha - / - mice to cyclophosphamide : the possible role of NF-kappaB .
17925009	0	TNFalpha	7,15	NF-kappaB	34,43	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	trimers|nsubj|START_ENTITY trimers|dobj|activation activation|amod|END_ENTITY	Single TNFalpha trimers mediating NF-kappaB activation : stochastic robustness of NF-kappaB signaling .
17925009	0	TNFalpha	7,15	NF-kappaB	81,90	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	trimers|nsubj|START_ENTITY trimers|dobj|activation activation|dep|robustness robustness|nmod|signaling signaling|compound|END_ENTITY	Single TNFalpha trimers mediating NF-kappaB activation : stochastic robustness of NF-kappaB signaling .
19414075	0	TNFalpha	0,8	NF-kappaB	95,104	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|triggering triggering|dobj|END_ENTITY	TNFalpha promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-kappaB signaling pathway .
19459480	0	TNFalpha	41,49	NF-kappaB	30,39	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	genes|compound|START_ENTITY -RSB-|nsubj|genes -RSB-|advmod|END_ENTITY	-LSB- Study of expression of TLR9 , NF-kappaB , TNFalpha genes in cells of cervical canal mucosa in pregnant women with herpesvirus_infection -RSB- .
20663918	0	TNFalpha	24,32	NF-kappaB	75,84	TNFalpha	NF-kappaB	7124	4790	Gene	Gene	stimulation|compound|START_ENTITY levels|nmod|stimulation induce|nsubj|levels induce|dobj|dynamics dynamics|nmod|responses responses|amod|END_ENTITY	Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells .
8612692	0	TNFalpha	24,32	NF-kappaB	61,70	TNFalpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	cytotoxicity|compound|START_ENTITY mechanisms|nmod|cytotoxicity mechanisms|dep|activation activation|nmod|translocation translocation|amod|END_ENTITY	Molecular mechanisms of TNFalpha cytotoxicity : activation of NF-kappaB and nuclear translocation .
11834148	0	TNFalpha	43,51	P38MAPK	21,28	TNFalpha	P38MAPK	7124	1432	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Regulative effect of P38MAPK on release of TNFalpha and NO from alveolar macrophages under endotoxin stimulation .
12811828	0	TNFalpha	54,62	PAI-1	14,19	TNFalpha	PAI-1	7124	5054	Gene	Gene	syntheses|nmod|START_ENTITY syntheses|amod|END_ENTITY	Modulation of PAI-1 and proMMP-9 syntheses by soluble TNFalpha and its receptors during differentiation of the human monocytic HL-60 cell line .
15990085	0	TNFalpha	27,35	PAI-1	49,54	TNFalpha	PAI-1	7124	5054	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation .
19782747	0	TNFalpha	0,8	PKCdelta	23,31	TNFalpha	PKCdelta	7124	5580	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	TNFalpha activation of PKCdelta , mediated by NFkappaB and ER stress , cross-talks with the insulin signaling cascade .
12465041	0	TNFalpha	0,8	PPARdelta	23,32	TNFalpha	PPARdelta	7124	5467	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	TNFalpha downregulates PPARdelta expression in oligodendrocyte progenitor cells : implications for demyelinating_diseases .
18435913	0	TNFalpha	28,36	Pkn1	52,56	TNFalpha	Pkn1	21926(Tax:10090)	320795(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse_osteosarcoma-derived FBJ cells .
11861538	0	TNFalpha	0,8	RANKL	110,115	TNFalpha	RANKL	24835(Tax:10116)	117516(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	TNFalpha potently activates osteoclasts , through a direct action independent of and strongly synergistic with RANKL .
19487969	0	TNFalpha	50,58	Ron	0,3	TNFalpha	Ron	21926(Tax:10090)	19882(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|kinase kinase|compound|END_ENTITY	Ron receptor tyrosine kinase negatively regulates TNFalpha production in alveolar macrophages by inhibiting NF-kappaB activity and Adam17 production .
10809911	0	TNFalpha	14,22	TNFalpha	86,94	TNFalpha	TNFalpha	7124	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|END_ENTITY	Expression of TNFalpha and TGFbeta1 in Guillain-Barr ___ syndrome : correlation of a low TNFalpha - / TGFbeta1-mRNA ratio with good recovery and signs for immunoregulation within the cerebrospinal fluid compartment .
10809911	0	TNFalpha	86,94	TNFalpha	14,22	TNFalpha	TNFalpha	7124	7124	Gene	Gene	correlation|nmod|START_ENTITY Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of TNFalpha and TGFbeta1 in Guillain-Barr ___ syndrome : correlation of a low TNFalpha - / TGFbeta1-mRNA ratio with good recovery and signs for immunoregulation within the cerebrospinal fluid compartment .
16432762	0	TNFalpha	24,32	Xaf1	0,4	TNFalpha	Xaf1	7124	54739	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Xaf1 can cooperate with TNFalpha in the induction of apoptosis , independently of interaction with XIAP .
9350999	0	TNFalpha	42,50	apoC-III	14,22	TNFalpha	apoC-III	7124	345	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Repression of apoC-III gene expression by TNFalpha involves C/EBPdelta/NF-IL 6beta via an IL-1 independent pathway .
18047469	0	TNFalpha	93,101	c-Jun_N-terminal_kinase	106,129	TNFalpha	c-Jun N-terminal kinase	7124	5599	Gene	Gene	START_ENTITY|nmod|signalling signalling|amod|END_ENTITY	Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFalpha via c-Jun_N-terminal_kinase signalling .
11689211	0	TNFalpha	0,8	c-fos	53,58	TNFalpha	c-fos	24835(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	TNFalpha induces expression of transcription factors c-fos , Egr-1 , and Ets-1 in vascular_lesions through extracellular_signal-regulated_kinases_1 / 2 .
19119023	0	TNFalpha	50,58	caspase-8	68,77	TNFalpha	caspase-8	21926(Tax:10090)	12370(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|xcomp|END_ENTITY	Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim .
19214581	0	TNFalpha	0,8	claudin-2	22,31	TNFalpha	claudin-2	7124	9075	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNFalpha up-regulates claudin-2 expression in epithelial HT-29 / B6 cells via phosphatidylinositol-3-kinase signaling .
12829187	0	TNFalpha	42,50	eNOS	18,22	TNFalpha	eNOS	7124	4846	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of eNOS mRNA expression by TNFalpha : identification and functional characterization of RNA-protein interactions in the 3 ` UTR .
17960400	0	TNFalpha	132,140	heparin-binding_EGF-like_growth_factor	12,50	TNFalpha	heparin-binding EGF-like growth factor	7124	1839	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of heparin-binding_EGF-like_growth_factor and amphiregulin in the epidermal proliferation of psoriasis in cooperation with TNFalpha .
12379886	0	TNFalpha	0,8	interleukin-10	10,24	TNFalpha	interleukin-10	7124	3586	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	TNFalpha , interleukin-10 and interleukin-18 expression in cells of the bronchoalveolar lavage in patients with pulmonary_complications following bone marrow or peripheral stem cell transplantation : a preliminary study .
18565597	0	TNFalpha	73,81	interleukin-10	99,113	TNFalpha	interleukin-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|acl|lacking lacking|xcomp|END_ENTITY	Exaggerated expression of skeletal muscle-derived interleukin-6 , but not TNFalpha , in mice lacking interleukin-10 .
9620892	0	TNFalpha	44,52	interleukin-10	18,32	TNFalpha	interleukin-10	7124	3586	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Recombinant human interleukin-10 attenuates TNFalpha production by porcine monocytes .
8772198	0	TNFalpha	186,194	interleukin_1alpha	131,149	TNFalpha	interleukin 1alpha	7124	3552	Gene	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- induces pro-matrix_metalloproteinase_9 production in human uterine cervical fibroblasts but interleukin_1alpha antagonizes the inductive effect of TNFalpha .
10699463	0	TNFalpha	8,16	myeloperoxidase	34,49	TNFalpha	myeloperoxidase	7124	4353	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of TNFalpha in regulation of myeloperoxidase expression in irradiated HL60 promyelocytic cells .
20670427	0	TNFalpha	96,104	oxytocin_receptor	33,50	TNFalpha	oxytocin receptor	7124	5021	Gene	Gene	Regulation|nmod|START_ENTITY Expression|dep|Regulation Expression|nmod|END_ENTITY	Expression and activation of the oxytocin_receptor in airway smooth muscle cells : Regulation by TNFalpha and IL-13 .
11740866	0	TNFalpha	0,8	p47	55,58	TNFalpha	p47	7124	5341	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	TNFalpha activates c-Jun amino terminal kinase through p47 -LRB- phox -RRB- .
18475579	0	TNFalpha	67,75	p55	18,21	TNFalpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	Chemotaxis|nmod|START_ENTITY Chemotaxis|nsubj|END_ENTITY	The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFalpha and a TNFalpha 36-62 Peptide .
9890556	0	TNFalpha	96,104	p55	92,95	TNFalpha	p55	7124	7132	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Enhancement of the surface expression of tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- but not the p55 TNFalpha receptor in the THP-1 monocytic cell line by matrix metalloprotease inhibitors .
8621742	0	TNFalpha	43,51	tumor_necrosis_factor_alpha	14,41	TNFalpha	tumor necrosis factor alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- activity in rat brain is associated with cerebroprotection after closed_head_injury .
22449978	0	TNKS2	54,59	miR-20a	0,7	TNKS2	miR-20a	80351	406982	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	miR-20a promotes migration and invasion by regulating TNKS2 in human cervical_cancer cells .
16298793	0	TNM	146,149	IL-6	81,85	TNM	IL-6	10178	3569	Gene	Gene	related|xcomp|START_ENTITY related|nsubjpass|END_ENTITY	Head_and_neck_squamous_cell_carcinoma spheroid - and monocyte spheroid-stimulated IL-6 and monocyte_chemotactic_protein-1 secretion are related to TNM stage , inflammatory state and tumor macrophage density .
26597366	0	TNM	111,114	TNM	138,141	TNM	TNM	10178	10178	Gene	Gene	START_ENTITY|nmod|System System|compound|END_ENTITY	Is There Any Role of Adjuvant Chemotherapy for T3N0M0 or T1N2M0 Gastric_Cancer Patients in Stage II in the 7th TNM but Stage I in the 6th TNM System ?
26597366	0	TNM	138,141	TNM	111,114	TNM	TNM	10178	10178	Gene	Gene	System|compound|START_ENTITY END_ENTITY|nmod|System	Is There Any Role of Adjuvant Chemotherapy for T3N0M0 or T1N2M0 Gastric_Cancer Patients in Stage II in the 7th TNM but Stage I in the 6th TNM System ?
8513568	1	TNM	170,173	epidermal_growth_factor_receptor	107,139	TNM	epidermal growth factor receptor	10178	1956	Gene	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	Its relationship to epidermal_growth_factor_receptor , estradiol_receptor and tumor TNM .
9543552	0	TNNI2	58,63	troponin_I	41,51	TNNI2	troponin I	7136	7136	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization of the fast skeletal muscle troponin_I gene -LRB- TNNI2 -RRB- to 11p15 .5 : genes for troponin_I and T are organized in pairs .
25430424	0	TNNT1	81,86	troponin_T1	68,79	TNNT1	troponin T1	7138	7138	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel nemaline_myopathy-Causing mutation in the troponin_T1 -LRB- TNNT1 -RRB- gene : A case outside of the old order amish .
22872640	0	TNPO3	62,67	transportin_3	39,52	TNPO3	transportin 3	23534	23534	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Interaction of the HIV-1 intasome with transportin_3 protein -LRB- TNPO3 or TRN-SR2 -RRB- .
18769035	0	TNR-CFTR	54,62	U11	19,22	TNR-CFTR	U11	1080;7143	26824	Gene	Gene	mRNA|compound|START_ENTITY END_ENTITY|nmod|mRNA	Small nuclear RNAs U11 and U12 modulate expression of TNR-CFTR mRNA in mammalian kidneys .
18358451	0	TNRC15	25,31	GIGYF2	17,23	TNRC15	GIGYF2	26058	26058	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in the GIGYF2 -LRB- TNRC15 -RRB- gene at the PARK11 locus in familial_Parkinson_disease .
18358451	0	TNRC15	25,31	PARK11	45,51	TNRC15	PARK11	26058	26058	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Mutations in the GIGYF2 -LRB- TNRC15 -RRB- gene at the PARK11 locus in familial_Parkinson_disease .
23447579	0	TNRC9	0,5	BRCA1	20,25	TNRC9	BRCA1	244579(Tax:10090)	12189(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	TNRC9 downregulates BRCA1 expression and promotes breast_cancer_aggressiveness .
10094560	0	TNSALP	174,180	tissue-nonspecific_alkaline_phosphatase	133,172	TNSALP	tissue-nonspecific alkaline phosphatase	249	249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of eleven novel mutations -LRB- M45L , R119H , 544delG , G145V , H154Y , C184Y , D289V , 862 +5 A , 1172delC , R411X , E459K -RRB- in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene in patients with severe hypophosphatasia .
10679946	0	TNSALP	187,193	tissue-nonspecific_alkaline_phosphatase	146,185	TNSALP	tissue-nonspecific alkaline phosphatase	249	249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Fifteen new mutations -LRB- -195 C > T , L-12X , 298-2A > G , T117N , A159T , R229S , 997 +2 T > A , E274X , A331T , H364R , D389G , 1256delC , R433H , N461I , C472S -RRB- in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene in patients with hypophosphatasia .
11745997	0	TNSALP	216,222	tissue-nonspecific_alkaline_phosphatase	175,214	TNSALP	tissue-nonspecific alkaline phosphatase	249	249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Perinatal hypophosphatasia : radiology , pathology and molecular biology studies in a family harboring a splicing mutation -LRB- 648 +1 A -RRB- and a novel missense mutation -LRB- N400S -RRB- in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene .
12357339	0	TNSALP	78,84	tissue-nonspecific_alkaline_phosphatase	37,76	TNSALP	tissue-nonspecific alkaline phosphatase	249	249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence of a founder effect for the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene E174K mutation in hypophosphatasia patients .
12416636	0	TNSALP	89,95	tissue-nonspecific_alkaline_phosphatase	48,87	TNSALP	tissue-nonspecific alkaline phosphatase	249	249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Severe hypophosphatasia due to mutations in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene .
9781036	0	TNSALP	90,96	tissue-nonspecific_alkaline_phosphatase	49,88	TNSALP	tissue-nonspecific alkaline phosphatase	249	249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of fifteen novel mutations in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene in European patients with severe hypophosphatasia .
17765603	0	TNT	67,70	EDA	45,48	TNT	EDA	162083	1896	Gene	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	Absorption spectroscopic and FTIR studies on EDA complexes between TNT -LRB- 2,4,6-trinitrotoluene -RRB- with amines in DMSO and determination of the vertical electron affinity of TNT .
7472434	0	TOAD-64	0,7	unc-33	86,92	TOAD-64	unc-33	25416(Tax:10116)	177112(Tax:6239)	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	TOAD-64 , a gene expressed early in neuronal differentiation in the rat , is related to unc-33 , a C. _ elegans gene involved in axon outgrowth .
19491269	0	TOB1	0,4	HER2	35,39	TOB1	HER2	10140	2064	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	TOB1 is regulated by EGF-dependent HER2 and EGFR signaling , is highly phosphorylated , and indicates poor prognosis in node-negative_breast_cancer .
21358285	0	TOC1	32,36	JMJD5	0,5	TOC1	JMJD5	836259(Tax:3702)	79831	Gene	Gene	Functions|nmod|START_ENTITY Functions|compound|END_ENTITY	JMJD5 Functions in concert with TOC1 in the arabidopsis circadian system .
19098071	0	TOC1	101,105	TIMING_OF_CAB_EXPRESSION_1	73,99	TOC1	TIMING OF CAB EXPRESSION 1	836259(Tax:3702)	836259(Tax:3702)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A genetic study of the Arabidopsis circadian clock with reference to the TIMING_OF_CAB_EXPRESSION_1 -LRB- TOC1 -RRB- gene .
19508870	0	TOE1	0,4	p53	20,23	TOE1	p53	114034	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TOE1 interacts with p53 to modulate its transactivation potential .
17096026	0	TOM22	0,5	Bax	144,147	TOM22	Bax	56993	581	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	TOM22 , a core component of the mitochondria outer membrane protein translocation pore , is a mitochondrial receptor for the proapoptotic protein Bax .
23234877	0	TOMM40	105,111	KIR2DL5A	132,140	TOMM40	KIR2DL5A	10452	57292	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|nmod|END_ENTITY	Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A , PLOD1 , and SLC2A8 among fast progressors in early Alzheimer 's _ disease .
25777400	0	TOP1	166,170	topoisomerase_1	149,164	TOP1	topoisomerase 1	7150	7150	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2 - negative breast_cancer and increased copy numbers of the topoisomerase_1 -LRB- TOP1 -RRB- gene : a study protocol .
25885574	0	TOP1	166,170	topoisomerase_1	149,164	TOP1	topoisomerase 1	7150	7150	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2 - negative breast_cancer and increased copy numbers of the topoisomerase_1 -LRB- TOP1 -RRB- gene : a study protocol .
23577133	0	TOP1	31,35	topoisomerase_I	14,29	TOP1	topoisomerase I	7150	7150	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mechanisms of topoisomerase_I -LRB- TOP1 -RRB- gene copy number increase in a stage III colorectal_cancer patient cohort .
26252353	0	TOP2A	13,18	CYP19A1	20,27	TOP2A	CYP19A1	7153	1588	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	TOP2A	13,18	CYP19A1	20,27	TOP2A	CYP19A1	7153	1588	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26657567	0	TOP2A	16,21	PTEN	0,4	TOP2A	PTEN	7153	5728	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	PTEN stabilizes TOP2A and regulates the DNA decatenation .
26252353	0	TOP2A	13,18	RRM1	0,4	TOP2A	RRM1	7153	6240	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	TOP2A	13,18	RRM1	0,4	TOP2A	RRM1	7153	6240	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
25762097	0	TOP2A	16,21	TOPBP1	0,6	TOP2A	TOPBP1	7153	11073	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution .
26252353	0	TOP2A	13,18	TUBB3	6,11	TOP2A	TUBB3	7153	10381	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	TOP2A	13,18	TUBB3	6,11	TOP2A	TUBB3	7153	10381	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
20566845	0	TOPBP1	58,64	ATR	30,33	TOPBP1	ATR	11073	545	Gene	Gene	degradation|compound|START_ENTITY promoting|dobj|degradation inhibits|advcl|promoting inhibits|dobj|activation activation|compound|END_ENTITY	Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation .
23582259	0	TOPBP1	49,55	ATR	30,33	TOPBP1	ATR	398573(Tax:8355)	398197(Tax:8355)	Gene	Gene	recruitment|compound|START_ENTITY role|nmod|recruitment role|nmod|activation activation|compound|END_ENTITY	A role for the MRN complex in ATR activation via TOPBP1 recruitment .
25762097	0	TOPBP1	0,6	TOP2A	16,21	TOPBP1	TOP2A	11073	7153	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution .
20647304	0	TOPK	38,42	Prx1	63,67	TOPK	Prx1	55872	5052	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
20647304	0	TOPK	38,42	T-LAK_cell-originated_protein_kinase	0,36	TOPK	T-LAK cell-originated protein kinase	55872	55872	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity .
21715333	0	TOPK	38,42	T-LAK_cell-originated_protein_kinase	0,36	TOPK	T-LAK cell-originated protein kinase	52033(Tax:10090)	52033(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	T-LAK_cell-originated_protein_kinase -LRB- TOPK -RRB- phosphorylation of MKP1 protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein signaling pathway .
17369395	0	TOR	38,41	AKT	14,17	AKT	AKT	41957(Tax:7227)	41957(Tax:7227)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|compound|END_ENTITY	Re-evaluating AKT regulation : role of TOR complex 2 in tissue growth .
22328503	0	TOR	41,44	IQGAP1	20,26	TOR	IQGAP1	21977(Tax:10090)	8826	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	A conserved role of IQGAP1 in regulating TOR complex 1 .
27001890	0	TOR	34,37	TFEB	25,29	TOR	TFEB	6097	7942	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals .
25337725	0	TOR1-A	23,29	DYT1	31,35	TOR1-A	DYT1	1861	1861	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Genetic evaluation for TOR1-A -LRB- DYT1 -RRB- in Brazilian patients with dystonia .
11523564	0	TOR1A	22,27	DYT1	29,33	TOR1A	DYT1	1861	1861	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel mutation in the TOR1A -LRB- DYT1 -RRB- gene in atypical early onset dystonia and polymorphisms_in_dystonia and early onset parkinsonism .
22556409	0	TORC1	174,179	ERK	106,109	TORC1	ERK	23373	5594	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
22424774	0	TORC1	32,37	Leucyl-tRNA_synthetase	0,22	TORC1	Leucyl-tRNA synthetase	23373	51520	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Leucyl-tRNA_synthetase controls TORC1 via the EGO complex .
25117580	0	TORC1	0,5	Pah1	16,20	TORC1	Pah1	23373	855201(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex .
17560372	0	TORC1	26,31	Sch9	0,4	TORC1	Sch9	23373	856612(Tax:4932)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Sch9 is a major target of TORC1 in Saccharomyces_cerevisiae .
22863314	0	TORC1	33,38	TRPML	11,16	TORC1	TRPML	47396(Tax:7227)	40152(Tax:7227)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Drosophila TRPML is required for TORC1 activation .
22500735	0	TORC1	72,77	leucyl-tRNA_synthetase	10,32	TORC1	leucyl-tRNA synthetase	23373	51520	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Hijacking leucyl-tRNA_synthetase for amino_acid-dependent regulation of TORC1 .
19254569	0	TORC2	0,5	insulin	24,31	TORC2	insulin	200186	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic_acid phosphatase , LIPIN1 .
21756805	0	TOSO	43,47	CD19	51,55	TOSO	CD19	9214	930	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	-LSB- Expression and prognostic significance of TOSO in CD19 + B cells from Chinese CLL patients -RSB- .
25352127	0	TOX2	0,4	T-BET	68,73	TOX2	T-BET	84969	30009	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	TOX2 regulates human natural killer cell development by controlling T-BET expression .
15041794	0	TP	86,88	VEGF	51,55	TP	VEGF	1890	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	combination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and thymidine_phosphorylase -LRB- TP -RRB- to improve angiogenic gene therapy .
12820387	0	TP	37,39	thymidine_phosphorylase	12,35	TP	thymidine phosphorylase	1890	1890	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of thymidine_phosphorylase -LRB- TP -RRB- mRNA expression in angiogenesis of prostate_cancer .
7933133	0	TP1	48,51	EBNA2	115,120	TP1	EBNA2	7141	17494192	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Crucial sequences within the Epstein-Barr_virus TP1 promoter for EBNA2-mediated transactivation and interaction of EBNA2 with its responsive element .
26312837	0	TP53	12,16	AGO2	39,43	TP53	AGO2	7157	27161	Gene	Gene	role|nmod|START_ENTITY role|acl|loading loading|nmod|END_ENTITY	The role of TP53 in miRNA loading onto AGO2 and in remodelling the miRNA-mRNA interaction network .
26701625	0	TP53	0,4	AGO2	38,42	TP53	AGO2	7157	27161	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network .
17721920	0	TP53	56,60	AKT	14,17	TP53	AKT	7157	207	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal_squamous_cell_carcinoma .
16314841	0	TP53	29,33	ASPP1	0,5	TP53	ASPP1	7157	23368	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	ASPP1 , a common activator of TP53 , is inactivated by aberrant methylation of its promoter in acute_lymphoblastic_leukemia .
10337991	0	TP53	23,27	BRCA1	41,46	TP53	BRCA1	7157	672	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|END_ENTITY	Increased frequency of TP53 mutations in BRCA1 and BRCA2 ovarian_tumours .
10432928	0	TP53	10,14	BRCA1	117,122	TP53	BRCA1	7157	672	Gene	Gene	mutations|compound|START_ENTITY mutations|acl|exhibiting exhibiting|dobj|features features|nmod|Li-Fraumeni_syndrome Li-Fraumeni_syndrome|nmod|END_ENTITY	Germ-line TP53 mutations in Finnish cancer families exhibiting features of the Li-Fraumeni_syndrome and negative for BRCA1 and BRCA2 .
11358831	0	TP53	0,4	BRCA1	48,53	TP53	BRCA1	7157	672	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|breast_cancer breast_cancer|acl|associated associated|nmod|mutations mutations|nummod|END_ENTITY	TP53 mutations in breast_cancer associated with BRCA1 or BRCA2 germ-line mutations : distinctive spectrum and structural distribution .
16229746	0	TP53	0,4	BRCA1	86,91	TP53	BRCA1	7157	672	Gene	Gene	mutations|nummod|START_ENTITY mutations|nmod|ovarian_carcinomas ovarian_carcinomas|nmod|cases cases|nmod|mutations mutations|compound|END_ENTITY	TP53 mutations in ovarian_carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations ; relation to age at diagnosis and survival .
17541742	0	TP53	9,13	BRCA1	27,32	TP53	BRCA1	7157	672	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Germline TP53 mutations in BRCA1 and BRCA2 mutation-negative French Canadian breast_cancer families .
18402691	0	TP53	22,26	BRCA1	65,70	TP53	BRCA1	7157	672	Gene	Gene	polymorphisms|nummod|START_ENTITY analysis|nmod|polymorphisms analysis|nmod|carriers carriers|compound|END_ENTITY	Haplotype analysis of TP53 polymorphisms , Arg72Pro and Ins16 , in BRCA1 and BRCA2 mutation carriers of French Canadian descent .
19707196	0	TP53	4,8	BRCA1	94,99	TP53	BRCA1	7157	672	Gene	Gene	Arg72Pro|nummod|START_ENTITY associated|nsubjpass|Arg72Pro associated|nmod|risk risk|nmod|carriers carriers|compound|END_ENTITY	The TP53 Arg72Pro and MDM2 309G > T polymorphisms are not associated with breast_cancer risk in BRCA1 and BRCA2 mutation carriers .
22507745	0	TP53	105,109	BRCA1	24,29	TP53	BRCA1	7157	672	Gene	Gene	screening|compound|START_ENTITY offered|nsubjpass|screening suggests|ccomp|offered germline|ccomp|suggests germline|nsubj|frequency frequency|nmod|END_ENTITY	Comparable frequency of BRCA1 , BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast_cancer patients .
23664366	0	TP53	159,163	BRCA1	133,138	TP53	BRCA1	22059(Tax:10090)	12189(Tax:10090)	Gene	Gene	haploinsufficiency|compound|START_ENTITY initiated|nmod|haploinsufficiency initiated|nmod|loss loss|nmod|END_ENTITY	The PPARy agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency .
26140185	0	TP53	0,4	BRCA1	16,21	TP53	BRCA1	7157	672	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro .
26140185	0	TP53	0,4	BRCA1	16,21	TP53	BRCA1	7157	672	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	TP53 Binding to BRCA1 and RAD51 in MCF7 and MDA-MB-468 Breast Cancer Cell Lines In vivo and In vitro .
11519857	0	TP53	0,4	Bcl-2	70,75	TP53	Bcl-2	7157	596	Gene	Gene	mutations|nummod|START_ENTITY mutations|appos|END_ENTITY	TP53 gene mutations , nuclear p53 accumulation , expression of Waf/p21 , Bcl-2 , and CD95 -LRB- APO-1 / Fas -RRB- proteins are not prognostic factors in de novo glioblastoma multiforme .
16356391	0	TP53	0,4	Bcl-2	6,11	TP53	Bcl-2	7157	596	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	TP53 , Bcl-2 and growth_hormone receptor expression in cutaneous_squamous_cell_carcinoma .
22077405	0	TP53	40,44	Bcl-2	68,73	TP53	Bcl-2	403869(Tax:9615)	403416(Tax:9615)	Gene	Gene	Detection|nmod|START_ENTITY Detection|nmod|proteins proteins|compound|END_ENTITY	Detection of the tumour suppressor gene TP53 and expression of p53 , Bcl-2 and p63 proteins in canine transmissible venereal_tumour .
10398121	0	TP53	0,4	CDK4	83,87	TP53	CDK4	7157	1019	Gene	Gene	alterations|nsubj|START_ENTITY alterations|nmod|cell cell|acl|cycle-associated cycle-associated|xcomp|proteins proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
9546285	0	TP53	53,57	CDKN2A	25,31	TP53	CDKN2A	7157	1029	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL .
22420423	0	TP53	55,59	CHEK2	48,53	TP53	CHEK2	7157	11200	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Low expression levels of ATM may substitute for CHEK2 / TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast_cancer .
23613880	0	TP53	56,60	ID4	27,30	TP53	ID4	7157	3400	Gene	Gene	levels|compound|START_ENTITY expression|nmod|levels expression|nmod|END_ENTITY	Differential expression of ID4 and its association with TP53 mutation , SOX2 , SOX4 and OCT-4 expression levels .
11668501	0	TP53	33,37	KRAS	45,49	TP53	KRAS	7157	3845	Gene	Gene	NRAS|dep|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
15923430	0	TP53	9,13	Ki-ras	21,27	TP53	Ki-ras	7157	3845	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal_adenocarcinomas : results of a 5-year Gruppo Oncologico dell ` Italia Meridionale -LRB- GOIM -RRB- prospective study .
15254976	0	TP53	86,90	LSH	53,56	TP53	LSH	7157	3070	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	TP53 in gastric_cancer : mutations in the l3 loop and LSH motif DNA-binding domains of TP53 predict poor outcome .
10329038	0	TP53	58,62	MDM2	64,68	TP53	MDM2	7157	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	TP53	0,4	MDM2	93,97	TP53	MDM2	7157	4193	Gene	Gene	alterations|nsubj|START_ENTITY alterations|nmod|cell cell|acl|cycle-associated cycle-associated|xcomp|proteins proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
18262501	0	TP53	58,62	MDM2	13,17	TP53	MDM2	7157	4193	Gene	Gene	polymorphism|compound|START_ENTITY Influence|nmod|polymorphism Influence|nmod|SNP309 SNP309|compound|END_ENTITY	Influence of MDM2 SNP309 alone or in combination with the TP53 R72P polymorphism in oligodendroglial_tumors .
18462472	0	TP53	77,81	MDM2	28,32	TP53	MDM2	7157	4193	Gene	Gene	mutations|nummod|START_ENTITY polymorphisms|nmod|mutations polymorphisms|nmod|genes genes|compound|END_ENTITY	Common polymorphisms in the MDM2 and TP53 genes and the relationship between TP53 mutations and patient outcomes in glioblastomas .
19541936	0	TP53	77,81	MDM2	94,98	TP53	MDM2	22059(Tax:10090)	17246(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|xcomp|regulate regulate|dobj|expression expression|compound|END_ENTITY	NOLC1 , an enhancer of nasopharyngeal_carcinoma progression , is essential for TP53 to regulate MDM2 expression .
20520810	0	TP53	102,106	MDM2	11,15	TP53	MDM2	7157	4193	Gene	Gene	mutations|nummod|START_ENTITY carriers|nmod|mutations study|nmod|carriers risk|nmod|study polymorphisms|nmod|risk codon|dobj|polymorphisms codon|nsubj|Effects Effects|nmod|END_ENTITY	Effects of MDM2 , MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations .
23982177	0	TP53	55,59	MDM2	0,4	TP53	MDM2	7157	4193	Gene	Gene	status|nummod|START_ENTITY phenotypic|appos|status phenotypic|compound|END_ENTITY	MDM2 phenotypic and genotypic profiling , respective to TP53 genetic status , in diffuse_large_B-cell_lymphoma patients treated with rituximab-CHOP immunochemotherapy : a report from the International DLBCL Rituximab-CHOP Consortium Program .
25621298	0	TP53	116,120	MDM2	78,82	TP53	MDM2	7157	4193	Gene	Gene	mutation|compound|START_ENTITY cells|nmod|mutation combined|nmod|cells combined|nmod|END_ENTITY	MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation .
25621298	0	TP53	35,39	MDM2	78,82	TP53	MDM2	7157	4193	Gene	Gene	indicator|nmod|START_ENTITY expression|nmod|indicator reactivation|nsubj|expression reactivation|nmod|combined combined|nmod|END_ENTITY	MDM4 expression as an indicator of TP53 reactivation by combined targeting of MDM2 and MDM4 in cancer cells without TP53 mutation .
25842826	0	TP53	48,52	MDM2	66,70	TP53	MDM2	7157	4193	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|genes genes|nummod|END_ENTITY	-LSB- Association of polymorphic markers Arg72Pro of TP53 and T309g of MDM2 genes with non_small_cell_lung_cancer in Russians of Moscow region -RSB- .
7547235	0	TP53	65,69	MDM2	0,4	TP53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY irrespective|nmod|status rare|nmod|irrespective rare|nsubj|overexpression overexpression|compound|END_ENTITY	MDM2 overexpression is rare in ovarian_carcinoma irrespective of TP53 mutation status .
8721685	0	TP53	28,32	MDM2	66,70	TP53	MDM2	7157	4193	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene mutations|nmod|gene gene|compound|END_ENTITY	Infrequent mutations of the TP53 gene and no amplification of the MDM2 gene in hepatoblastomas .
9120719	0	TP53	0,4	MDM2	77,81	TP53	MDM2	7157	4193	Gene	Gene	accumulation|compound|START_ENTITY accumulation|nmod|relation relation|nmod|overexpression overexpression|nmod|END_ENTITY	TP53 protein accumulation and gene mutation in relation to overexpression of MDM2 protein_in_ovarian_borderline_tumours_and_stage_I_carcinomas .
22845047	0	TP53	99,103	MDM4	71,75	TP53	MDM4	7157	4194	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	TP53 pathway analysis in paediatric Burkitt_lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases .
11668501	0	TP53	33,37	NF2	28,31	TP53	NF2	7157	4771	Gene	Gene	NRAS|dep|START_ENTITY NRAS|compound|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
19541936	0	TP53	77,81	NOLC1	0,5	TP53	NOLC1	22059(Tax:10090)	70769(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	NOLC1 , an enhancer of nasopharyngeal_carcinoma progression , is essential for TP53 to regulate MDM2 expression .
23532381	0	TP53	86,90	PICT1	25,30	TP53	PICT1	7157	29997	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of PICT1 in patients of hepatocellular_carcinoma with wild-type TP53 .
24045667	0	TP53	16,20	PICT1	0,5	TP53	PICT1	7157	29997	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PICT1 regulates TP53 via RPL11 and is involved in gastric_cancer progression .
11668501	0	TP53	33,37	PTEN	39,43	TP53	PTEN	7157	5728	Gene	Gene	NRAS|dep|START_ENTITY NRAS|dep|END_ENTITY	Comparative analysis of the NF2 , TP53 , PTEN , KRAS , NRAS and HRAS genes in sporadic and radiation-induced human meningiomas .
17854663	0	TP53	0,4	and_1p	44,50	TP53	and 1p	7157	11169	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	TP53 codon 72 polymorphism , p53 expression , and_1p / 19q status in oligodendroglial_tumors .
15644269	0	TP53	75,79	caspase_activated_DNase	90,113	TP53	caspase activated DNase	7157	1677	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Modulation of age at_onset of Huntington_disease patients by variations in TP53 and human caspase_activated_DNase -LRB- hCAD -RRB- genes .
10329038	0	TP53	58,62	cdk4	80,84	TP53	cdk4	7157	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10329038	0	TP53	58,62	cyclin_D1	86,95	TP53	cyclin D1	7157	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	TP53	0,4	cyclin_D1	72,81	TP53	cyclin D1	7157	595	Gene	Gene	alterations|nsubj|START_ENTITY alterations|nmod|cell cell|acl|cycle-associated cycle-associated|xcomp|proteins proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
15644269	0	TP53	75,79	hCAD	115,119	TP53	hCAD	7157	730249	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Modulation of age at_onset of Huntington_disease patients by variations in TP53 and human caspase_activated_DNase -LRB- hCAD -RRB- genes .
17575133	0	TP53	24,28	p14arf	52,58	TP53	p14arf	7157	1029	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Patterns of EGFR , HER2 , TP53 , and KRAS mutations of p14arf expression in non-small_cell_lung_cancers in relation to smoking history .
10329038	0	TP53	58,62	p21	70,73	TP53	p21	7157	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	TP53	0,4	p21	67,70	TP53	p21	7157	1026	Gene	Gene	alterations|nsubj|START_ENTITY alterations|nmod|cell cell|acl|cycle-associated cycle-associated|xcomp|proteins proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
12243811	0	TP53	20,24	p21	53,56	TP53	p21	7157	644914	Gene	Gene	activity|compound|START_ENTITY value|nmod|activity value|nmod|END_ENTITY	Prognostic value of TP53 transcriptional activity on p21 and bax in patients with esophageal_squamous_cell_carcinomas treated by definitive chemoradiotherapy .
15161352	0	TP53	42,46	p21	59,62	TP53	p21	7157	1026	Gene	Gene	Accumulation|nmod|START_ENTITY Accumulation|appos|END_ENTITY	Accumulation of the cell cycle regulators TP53 and CDKN1A -LRB- p21 -RRB- in human fibroblasts after exposure to low - and high-LET radiation .
20966084	0	TP53	77,81	p21	83,86	TP53	p21	7157	1026	Gene	Gene	START_ENTITY|dep|CDKN1A CDKN1A|amod|END_ENTITY	DNA damage , DNA repair rates and mRNA expression levels of cell cycle genes -LRB- TP53 , p21 -LRB- CDKN1A -RRB- , BCL2_and_BAX -RRB- with respect to occupational exposure to styrene .
9010231	0	TP53	57,61	p21	0,3	TP53	p21	7157	1026	Gene	Gene	agents|nmod|START_ENTITY response|nmod|agents response|amod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- response to genotoxic agents in wild-type TP53 expressing breast primary tumours .
10329038	0	TP53	58,62	p27	75,78	TP53	p27	7157	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
16039051	0	TP53	33,37	p53	6,9	TP53	p53	7157	7157	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Human p53 tumor suppressor gene -LRB- TP53 -RRB- and schizophrenia : case-control and family studies .
9284922	0	TP53	40,44	p53	30,33	TP53	p53	100682525	100682525	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of Chinese_hamster p53 gene -LRB- TP53 -RRB- to chromosome band 2p31 , a region not involved in the karyotypic changes of a tumorigenic cell line .
9662253	0	TP53	17,21	p53	53,56	TP53	p53	7157	7157	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Mutations in the TP53 gene and protein expression of p53 , MDM 2 and p21/WAF -1 in primary cervical_carcinomas with no or low human_papillomavirus load .
8162331	0	TP53	0,4	tumor-suppressor	5,21	TP53	tumor-suppressor	7157	7248	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	TP53 tumor-suppressor gene and human carcinogenesis .
20646866	0	TP53BP1	83,90	p53_binding_protein_1	60,81	TP53BP1	p53 binding protein 1	7158	7158	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evaluation of single nucleotide polymorphisms -LRB- SNPs -RRB- in the p53_binding_protein_1 -LRB- TP53BP1 -RRB- gene in breast_cancer patients treated with breast-conserving surgery and whole-breast irradiation -LRB- BCS + RT -RRB- .
22421968	0	TP53INP1	0,8	LC3	45,48	TP53INP1	LC3	94241	84557	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|proteins proteins|compound|END_ENTITY	TP53INP1 , a tumor suppressor , interacts with LC3 and ATG8-family proteins through the LC3-interacting region -LRB- LIR -RRB- and promotes autophagy-dependent cell death .
25601564	0	TP53INP1	16,24	MiR-155	0,7	TP53INP1	MiR-155	94241	406947	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MiR-155 targets TP53INP1 to regulate liver_cancer stem cell acquisition and self-renewal .
22730212	0	TP53INP1	18,26	MiR-17-5p	0,9	TP53INP1	MiR-17-5p	94241	406952	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MiR-17-5p targets TP53INP1 and regulates cell proliferation and apoptosis of cervical_cancer cells .
25633840	0	TP53INP1	45,53	TGF-b1	0,6	TP53INP1	TGF-b1	94241	7040	Gene	Gene	acts|nmod|START_ENTITY acts|amod|END_ENTITY	TGF-b1 acts through miR-155 to down-regulate TP53INP1 in promoting epithelial-mesenchymal transition and cancer stem cell phenotypes .
17393983	0	TP53INP1	60,68	tumour_protein_p53-induced_nuclear_protein_1	14,58	TP53INP1	tumour protein p53-induced nuclear protein 1	94241	94241	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	High level of tumour_protein_p53-induced_nuclear_protein_1 -LRB- TP53INP1 -RRB- expression in anaplastic_carcinoma of the thyroid .
17661167	0	TPA	68,71	PAI-1	22,27	TPA	PAI-1	5327	5054	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|nmod|gene gene|compound|END_ENTITY	4G/5G polymorphism of PAI-1 gene and Alu-repeat I/D polymorphism of TPA gene in Turkish patients with polycystic_ovary_syndrome .
2124638	0	TPA	71,74	PAI-1	127,132	TPA	PAI-1	100128998	5054	Gene	Gene	tissue_plasminogen_activator|appos|START_ENTITY activity|nmod|tissue_plasminogen_activator correlation|nmod|activity -LSB-|dobj|correlation -RSB-|advcl|-LSB- -RSB-|nsubj|levels levels|nmod|antigen antigen|appos|END_ENTITY	-LSB- The correlation between the activity of tissue_plasminogen_activator -LRB- TPA -RRB- , levels of tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- antigen and serum lipids in healthy subjects -RSB- .
9264480	0	TPA	137,140	PAI-1	171,176	TPA	PAI-1	100128998	5054	Gene	Gene	antigen|compound|START_ENTITY relationship|nmod|antigen relationship|nmod|patients patients|nmod|levels levels|compound|END_ENTITY	Clearance of tissue_plasminogen_activator -LRB- TPA -RRB- and TPA/plasminogen _ activator_inhibitor_type_1 -LRB- PAI-1 -RRB- complex : relationship to elevated TPA antigen in patients with high PAI-1 activity levels .
9264480	0	TPA	43,46	PAI-1	171,176	TPA	PAI-1	100128998	5054	Gene	Gene	tissue_plasminogen_activator|appos|START_ENTITY Clearance|nmod|tissue_plasminogen_activator Clearance|dep|relationship relationship|nmod|patients patients|nmod|levels levels|compound|END_ENTITY	Clearance of tissue_plasminogen_activator -LRB- TPA -RRB- and TPA/plasminogen _ activator_inhibitor_type_1 -LRB- PAI-1 -RRB- complex : relationship to elevated TPA antigen in patients with high PAI-1 activity levels .
3390175	0	TPA	138,141	elongation_factor_2	94,113	TPA	elongation factor 2	112229(Tax:10090)	13629(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Effect of tumor promoting phorbol_ester_TPA on epidermal protein synthesis : stimulation of an elongation_factor_2 phosphatase activity by TPA in vivo .
10469621	0	TPA	89,92	p53	35,38	TPA	p53	112229(Tax:10090)	22060(Tax:10090)	Gene	Gene	-LSB-|nmod|START_ENTITY benzo|acl|-LSB- response|nmod|benzo response|compound|END_ENTITY	Thapsigargin has similar effect on p53 protein response to benzo -LSB- a -RSB- pyrene-DNA adducts as TPA in mouse skin .
21964832	0	TPA	41,44	p53	23,26	TPA	p53	5327	7157	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Effect of berberine on p53 expression by TPA in breast_cancer cells .
8185344	0	TPA	50,53	tissue-polypeptide_antigen	22,48	TPA	tissue-polypeptide antigen	5327	5327	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	-LSB- Measurement of serum tissue-polypeptide_antigen -LRB- TPA -RRB- levels by EIA employing monoclonal antibody -RSB- .
2346288	0	TPA	44,47	tissue_polypeptide_antigen	16,42	TPA	tissue polypeptide antigen	5327	5327	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Significance of tissue_polypeptide_antigen -LRB- TPA -RRB- levels in nasopharyngeal_cancer .
3908587	0	TPA	64,67	tissue_polypeptide_antigen	36,62	TPA	tissue polypeptide antigen	5327	5327	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immuno-histological localization of tissue_polypeptide_antigen -LRB- TPA -RRB- in gynecological malignancies .
6721513	0	TPA	49,52	tissue_polypeptide_antigen	21,47	TPA	tissue polypeptide antigen	5327	5327	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	-LSB- Evaluation of serum tissue_polypeptide_antigen -LRB- TPA -RRB- in patients with urogenital_cancer -RSB- .
7317745	0	TPA	57,60	tissue_polypeptide_antigen	29,55	TPA	tissue polypeptide antigen	5327	5327	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The clinical significance of tissue_polypeptide_antigen -LRB- TPA -RRB- in the urine of bladder_cancer patients .
18052984	0	TPA-inducible_sequence_7	32,56	cellular_retinoic_acid_binding_protein_II	93,134	TPA-inducible sequence 7	cellular retinoic acid binding protein II	15982(Tax:10090)	12904(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	The transcriptional corepressor TPA-inducible_sequence_7 regulates adult axon growth through cellular_retinoic_acid_binding_protein_II expression .
2693562	0	TPA_and_CA_19-9	17,32	CEA	12,15	TPA and CA 19-9	CEA	5327	1084	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of CEA , TPA_and_CA_19-9 in the early detection of recurrent colorectal_cancer .
19298454	0	TPC1	55,59	fou2	4,8	TPC1	fou2	825655(Tax:3702)	825655(Tax:3702)	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	The fou2 mutation in the major vacuolar cation channel TPC1 confers tolerance to inhibitory luminal calcium .
24604726	0	TPD52	42,47	PLP2	18,22	TPD52	PLP2	7163	5355	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of PLP2 and RAB5C as novel TPD52 binding partners through yeast two-hybrid screening .
10918393	0	TPD52	10,15	hD52	4,8	TPD52	hD52	7163	7163	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The hD52 -LRB- TPD52 -RRB- gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast_carcinoma .
22796107	0	TPH-1	103,108	tryptophan_hydroxylase-1	77,101	TPH-1	tryptophan hydroxylase-1	21990(Tax:10090)	21990(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Selective estrogen_receptor-beta -LRB- SERM-beta -RRB- compounds modulate raphe nuclei tryptophan_hydroxylase-1 -LRB- TPH-1 -RRB- mRNA expression and cause antidepressant-like effects in the forced swim test .
23221997	0	TPH1	0,4	MAOA	6,10	TPH1	MAOA	7166	4128	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	TPH1 , MAOA , serotonin receptor 2A and 2C genes in citalopram response : possible effect in melancholic and psychotic_depression .
17134762	0	TPH1	31,35	Tryptophan_hydroxylase_1	0,24	TPH1	Tryptophan hydroxylase 1	7166	7166	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tryptophan_hydroxylase_1 gene -LRB- TPH1 -RRB- moderates the influence of social support on depressive_symptoms in adults .
17870198	0	TPH1	30,34	tryptophan_hydroxylase_1	4,28	TPH1	tryptophan hydroxylase 1	7166	7166	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The tryptophan_hydroxylase_1 -LRB- TPH1 -RRB- gene and risk of schizophrenia : a moderate-scale case-control study and meta-analysis .
19526457	0	TPH1	30,34	tryptophan_hydroxylase_1	4,28	TPH1	tryptophan hydroxylase 1	7166	7166	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	The tryptophan_hydroxylase_1 -LRB- TPH1 -RRB- gene , schizophrenia susceptibility , and suicidal behavior : a multi-centre case-control study and meta-analysis .
16759340	0	TPH2	56,60	tryptophan_hydroxylase-2	30,54	TPH2	tryptophan hydroxylase-2	121278	121278	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of variations in the tryptophan_hydroxylase-2 -LRB- TPH2 -RRB- gene in cocaine_dependence .
19763617	0	TPH2	41,45	tryptophan_hydroxylase_2	15,39	TPH2	tryptophan hydroxylase 2	121278	121278	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Involvement of tryptophan_hydroxylase_2 -LRB- TPH2 -RRB- gene polymorphisms in susceptibility to coronary_artery_lesions in Korean children with Kawasaki_disease .
21765945	0	TPH2	46,50	tryptophan_hydroxylase_2	20,44	TPH2	tryptophan hydroxylase 2	467070(Tax:9598)	467070(Tax:9598)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism of the tryptophan_hydroxylase_2 -LRB- TPH2 -RRB- gene is associated with chimpanzee neuroticism .
22361444	0	TPH2	70,74	tryptophan_hydroxylase_2	44,68	TPH2	tryptophan hydroxylase 2	121278	121278	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A detailed association analysis between the tryptophan_hydroxylase_2 -LRB- TPH2 -RRB- gene and autism_spectrum_disorders in a Japanese population .
22721547	0	TPH2	55,59	tryptophan_hydroxylase_2	24,48	TPH2	tryptophan hydroxylase 2	121278	121278	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variants in the tryptophan_hydroxylase_2 gene -LRB- TPH2 -RRB- and depression during and after pregnancy .
15476687	0	TPH2	97,101	tryptophan_hydroxylase_isoform	65,95	TPH2	tryptophan hydroxylase isoform	121278	121278	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphism and haplotype analysis of a novel tryptophan_hydroxylase_isoform -LRB- TPH2 -RRB- gene in suicide victims .
9864381	0	TPI	65,68	triosephosphate_isomerase	14,39	TPI	triosephosphate isomerase	7167	7167	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of triosephosphate_isomerase -LRB- TPI -RRB- gene expression in TPI deficient_lymphoblastoid_cells .
17295612	0	TPK1	90,94	thiamine_pyrophosphokinase	57,83	TPK1	thiamine pyrophosphokinase	27010	27010	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Three common intronic variants in the maternal and fetal thiamine_pyrophosphokinase gene -LRB- TPK1 -RRB- are associated with birth weight .
22435554	0	TPL-2	29,34	ERK	35,38	TPL-2	ERK	1326	5594	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	IkB kinase regulation of the TPL-2 / ERK MAPK pathway .
22988300	0	TPL-2	23,28	IkB_kinase_2	0,12	TPL-2	IkB kinase 2	1326	3551	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	IkB_kinase_2 regulates TPL-2 activation of extracellular_signal-regulated_kinases_1_and_2 by direct phosphorylation of TPL-2 serine 400 .
22988300	0	TPL-2	23,28	extracellular_signal-regulated_kinases_1_and_2	43,89	TPL-2	extracellular signal-regulated kinases 1 and 2	1326	5595	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	IkB_kinase_2 regulates TPL-2 activation of extracellular_signal-regulated_kinases_1_and_2 by direct phosphorylation of TPL-2 serine 400 .
26318043	0	TPL2	0,4	IL-17R	14,20	TPL2	IL-17R	1326	23765	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	TPL2 mediates IL-17R signaling in neuroinflammation .
12651045	0	TPM1	87,91	alpha-tropomyosin	68,85	TPM1	alpha-tropomyosin	7168	7168	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variable clinical manifestation of a novel missense mutation in the alpha-tropomyosin -LRB- TPM1 -RRB- gene in familial hypertrophic_cardiomyopathy .
12196661	0	TPM3	53,57	alpha-tropomyosin	29,46	TPM3	alpha-tropomyosin	7170	7168	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations of the slow muscle alpha-tropomyosin gene , TPM3 , are a rare cause of nemaline_myopathy .
20951040	0	TPM3	84,88	tropomyosin_3	69,82	TPM3	tropomyosin 3	7170	7170	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Congenital fibre_type_disproportion associated with mutations in the tropomyosin_3 -LRB- TPM3 -RRB- gene mimicking congenital_myasthenia .
17026564	0	TPMT	30,34	Thiopurine_methyltransferase	0,28	TPMT	Thiopurine methyltransferase	7172	7172	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Thiopurine_methyltransferase -LRB- TPMT -RRB- activity and adverse effects of azathioprine in inflammatory_bowel_disease : long-term follow-up study of 394 patients .
11043513	0	TPMT	109,113	thiopurine_S-methyltransferase	77,107	TPMT	thiopurine S-methyltransferase	7172	7172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and multiple single-nucleotide polymorphisms -LRB- SNPs -RRB- of the thiopurine_S-methyltransferase -LRB- TPMT -RRB- gene .
16517227	0	TPMT	49,53	thiopurine_S-methyltransferase	17,47	TPMT	thiopurine S-methyltransferase	7172	7172	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Determination of thiopurine_S-methyltransferase -LRB- TPMT -RRB- activity by comparing various normalization factors : reference values for Estonian population using HPLC-UV assay .
9453052	0	TPMT	77,81	thiopurine_S-methyltransferase	45,75	TPMT	thiopurine S-methyltransferase	7172	7172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter and intronic sequences of the human thiopurine_S-methyltransferase -LRB- TPMT -RRB- gene isolated from a human PAC1 genomic library .
9780226	0	TPMT	73,77	thiopurine_S-methyltransferase	41,71	TPMT	thiopurine S-methyltransferase	7172	7172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional characterization of the human thiopurine_S-methyltransferase -LRB- TPMT -RRB- gene promoter .
11337944	0	TPMT	58,62	thiopurine_methyltransferase	28,56	TPMT	thiopurine methyltransferase	7172	7172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelotype frequency of the thiopurine_methyltransferase -LRB- TPMT -RRB- gene in Japanese .
12949626	0	TPMT	54,58	thiopurine_methyltransferase	24,52	TPMT	thiopurine methyltransferase	7172	7172	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic variants of the thiopurine_methyltransferase -LRB- TPMT -RRB- gene in the Colombian population .
16795981	0	TPMT	87,91	thiopurine_methyltransferase	57,85	TPMT	thiopurine methyltransferase	7172	7172	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Choice of azathioprine or 6-mercaptopurine dose based on thiopurine_methyltransferase -LRB- TPMT -RRB- activity to avoid myelosuppression .
7544303	0	TPO	16,19	STAT5	72,77	TPO	STAT5	7066	6776	Gene	Gene	Thrombopoietin|appos|START_ENTITY induces|nsubj|Thrombopoietin induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces tyrosine phosphorylation and activation of STAT5 and STAT3 .
9600081	0	TPO	131,134	Stat5	117,122	TPO	Stat5	7173	6776	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Thrombopoietin induces tyrosine phosphorylation of a common beta subunit of GM-CSF receptor and its association with Stat5 in TF-1 / TPO cells .
15763973	0	TPO	16,19	Thrombopoietin	0,14	TPO	Thrombopoietin	7066	7066	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Thrombopoietin -LRB- TPO -RRB- levels in hepatic patients with thrombocytopenia .
26575027	0	TPO	37,40	Thrombopoietin	21,35	TPO	Thrombopoietin	7066	7066	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	Markedly High Plasma Thrombopoietin -LRB- TPO -RRB- Level is a Predictor of Poor Response to Immunosuppressive Therapy in Children With Acquired Severe Aplastic_Anemia .
10936442	0	TPO	58,61	thrombopoietin	42,56	TPO	thrombopoietin	7066	7066	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Stressful delivery influences circulating thrombopoietin -LRB- TPO -RRB- levels in newborns : possible role for cortisol in TPO-mpl binding .
12101178	0	TPO	37,40	thrombopoietin	21,35	TPO	thrombopoietin	7066	7066	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	The glycan domain of thrombopoietin -LRB- TPO -RRB- acts in trans to enhance secretion of the hormone and other cytokines .
7498368	0	TPO	30,33	thrombopoietin	14,28	TPO	thrombopoietin	81811(Tax:10116)	81811(Tax:10116)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of thrombopoietin -LRB- TPO -RRB- by rat hepatocytes and hepatoma cell lines .
8950771	0	TPO	22,25	thrombopoietin	6,20	TPO	thrombopoietin	7066	7066	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum thrombopoietin -LRB- TPO -RRB- levels in patients with amegakaryocytic_thrombocytopenia are much higher than those with immune_thrombocytopenic_purpura .
10323395	0	TPO	51,54	thyroid_peroxidase	9,27	TPO	thyroid peroxidase	22018(Tax:10090)	22018(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Cellular thyroid_peroxidase -LRB- TPO -RRB- , unlike purified TPO and adjuvant , induces antibodies in mice that resemble autoantibodies in human autoimmune_thyroid_disease .
17381485	0	TPO	110,113	thyroid_peroxidase	90,108	TPO	thyroid peroxidase	7173	7173	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical and genetic characteristics of congenital_hypothyroidism due to mutations in the thyroid_peroxidase -LRB- TPO -RRB- gene in Israelis .
19243353	0	TPO	53,56	thyroid_peroxidase	33,51	TPO	thyroid peroxidase	7173	7173	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two novel mutations in the human thyroid_peroxidase -LRB- TPO -RRB- gene : genetics and clinical findings in four children .
23223904	0	TPO	22,25	thyroid_peroxidase	2,20	TPO	thyroid peroxidase	403521(Tax:9615)	403521(Tax:9615)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A thyroid_peroxidase -LRB- TPO -RRB- mutation in dogs reveals a canid-specific gene structure .
24420335	0	TPO	40,43	thyroid_peroxidase	20,38	TPO	thyroid peroxidase	7173	7173	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic analysis of thyroid_peroxidase -LRB- TPO -RRB- gene in patients whose hypothyroidism was found in adulthood in West Bengal , India .
24482635	0	TPO	70,73	thyroid_peroxidase	50,68	TPO	thyroid peroxidase	7173	7173	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Detection of heterozygous c. 1708C > T and c. 1978C > G thyroid_peroxidase -LRB- TPO -RRB- mutations in Iraqi patients with toxic and nontoxic_goiter .
8440133	0	TPO	63,66	thyroid_peroxidase	38,56	TPO	thyroid peroxidase	7173	7173	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regional sublocalization of the human thyroid_peroxidase gene -LRB- TPO -RRB- by tritium and fluorescence in situ hybridization to chromosome 2p25 -- > p24 .
17204413	0	TPOX	73,77	thyroid_peroxidase	53,71	TPOX	thyroid peroxidase	7173	7173	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Determination of microsatellite repeats in the human thyroid_peroxidase -LRB- TPOX -RRB- gene using an automated gene analysis system with nanoscale engineered biomagnetite .
19648609	0	TPP1	85,89	OB_fold-containing_protein_1	0,28	TPP1	OB fold-containing protein 1	855188(Tax:4932)	79991	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	OB_fold-containing_protein_1 -LRB- OBFC1 -RRB- , a human homolog of yeast Stn1 , associates with TPP1 and is implicated in telomere length regulation .
21829167	0	TPP1	26,30	UPF1	6,10	TPP1	UPF1	1200	5976	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication .
20308065	0	TPPP/p25	0,8	histone_deacetylase_6	52,73	TPPP/p25	histone deacetylase 6	11076	10013	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	TPPP/p25 promotes tubulin acetylation by inhibiting histone_deacetylase_6 .
11101887	0	TPR	50,53	PEX5	71,75	TPR	PEX5	7175	5830	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5 .
10901163	0	TPS1	110,114	trehalose-6-phosphate_synthase	78,108	TPS1	trehalose-6-phosphate synthase	852423(Tax:4932)	852423(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic engineering of drought resistant potato plants by introduction of the trehalose-6-phosphate_synthase -LRB- TPS1 -RRB- gene from Saccharomyces_cerevisiae .
24951963	0	TPS1	97,101	trehalose-6-phosphate_synthase	60,90	TPS1	trehalose-6-phosphate synthase	852423(Tax:4932)	852423(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Enhanced freeze tolerance of baker 's _ yeast by overexpressed trehalose-6-phosphate_synthase gene -LRB- TPS1 -RRB- and deleted trehalase genes in frozen dough .
25797204	0	TPSAB1	37,43	Tryptase_1	25,35	TPSAB1	Tryptase 1	7177	7177	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Alpha tryptase allele of Tryptase_1 -LRB- TPSAB1 -RRB- gene associated with Dengue_Hemorrhagic_Fever -LRB- DHF -RRB- and Dengue_Shock_Syndrome -LRB- DSS -RRB- in Vietnam and Philippines .
14580337	0	TPX2	43,47	Aurora-A	20,28	TPX2	Aurora-A	22974	6790	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|basis basis|nmod|END_ENTITY	Structural basis of Aurora-A activation by TPX2 at the mitotic spindle .
21187329	0	TPX2	141,145	Aurora_A	109,117	TPX2	Aurora A	22974	6790	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Protein_phosphatase_6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora_A bound to its activator TPX2 .
21969468	0	TPX2	0,4	Eg5	48,51	TPX2	Eg5	22974	3832	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle .
26018074	0	TPX2	0,4	Eg5	14,17	TPX2	Eg5	22974	3832	Gene	Gene	Inhibits|compound|START_ENTITY END_ENTITY|nsubj|Inhibits	TPX2 Inhibits Eg5 by Interactions with both Motor and Microtubule .
26018074	0	TPX2	0,4	Eg5	14,17	TPX2	Eg5	22974	3832	Gene	Gene	Inhibits|compound|START_ENTITY END_ENTITY|nsubj|Inhibits	TPX2 Inhibits Eg5 by Interactions with both Motor and Microtubule .
26165940	0	TPX2	61,65	GM130	0,5	TPX2	GM130	22974	2801	Gene	Gene	Assembly|nmod|START_ENTITY Assembly|compound|END_ENTITY	GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules .
18799614	0	TPX2	102,106	Hepatoma_up-regulated_protein	0,29	TPX2	Hepatoma up-regulated protein	398174(Tax:8355)	494809(Tax:8355)	Gene	Gene	assembly|nmod|START_ENTITY required|nmod|assembly required|nsubjpass|END_ENTITY	Hepatoma_up-regulated_protein is required for chromatin-induced microtubule assembly independently of TPX2 .
1709244	0	TQ1	45,48	leukocyte_adhesion_molecule-1	14,43	TQ1	leukocyte adhesion molecule-1	6402	6402	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of leukocyte_adhesion_molecule-1 -LRB- TQ1 , Leu-8 -RRB- expression and shedding by normal and malignant cells .
17389641	0	TR2	24,27	RIP140	159,165	TR2	RIP140	7181	8204	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Orphan nuclear receptor TR2 , a mediator of preadipocyte proliferation , is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1 .
9774688	0	TR2	88,91	RIP140	38,44	TR2	RIP140	22025(Tax:10090)	268903(Tax:10090)	Gene	Gene	corepressor|nmod|START_ENTITY END_ENTITY|appos|corepressor	Cloning and characterization of mouse RIP140 , a corepressor for nuclear orphan receptor TR2 .
12949936	0	TR2	0,3	androgen_receptor	56,73	TR2	androgen receptor	7181	367	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	TR2 orphan receptor functions as negative modulator for androgen_receptor in prostate_cancer cells PC-3 .
8626614	0	TR2	63,66	erythropoietin	25,39	TR2	erythropoietin	7181	2056	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|compound|END_ENTITY	Suppression of the human erythropoietin gene expression by the TR2 orphan receptor , a member of the steroid receptor superfamily .
14612408	0	TR3	36,39	MEKK1	62,67	TR3	MEKK1	3164	4214	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Mitogenic effect of orphan receptor TR3 and its regulation by MEKK1 in lung_cancer cells .
22002310	0	TR3	71,74	Pin1	17,21	TR3	Pin1	3164	5300	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis .
22081070	0	TR3	21,24	mTORC1	35,41	TR3	mTORC1	3164	382056(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The nuclear receptor TR3 regulates mTORC1 signaling in lung_cancer cells expressing wild-type p53 .
17139261	0	TR3	64,67	p53	0,3	TR3	p53	3164	7157	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	p53 mediates the negative regulation of MDM2 by orphan receptor TR3 .
21659476	0	TR3	16,19	p53	29,32	TR3	p53	3164	7157	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|transactivation transactivation|compound|END_ENTITY	Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation .
22081070	0	TR3	21,24	p53	94,97	TR3	p53	3164	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|mTORC1 mTORC1|acl|signaling signaling|advcl|expressing expressing|dobj|END_ENTITY	The nuclear receptor TR3 regulates mTORC1 signaling in lung_cancer cells expressing wild-type p53 .
21515881	0	TR4	51,54	ARA55	91,96	TR4	ARA55	7182	7041	Gene	Gene	receptor|nummod|START_ENTITY receptor|nmod|END_ENTITY	Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation .
21843524	0	TR4	0,3	FATP1	14,19	TR4	FATP1	7182	376497	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nummod|END_ENTITY	TR4 activates FATP1 gene expression to promote lipid accumulation in 3T3-L1 adipocytes .
26383271	0	TRA	42,45	TRD	58,61	TRA	TRD	6955	280945(Tax:9913)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Sheep -LRB- Ovis_aries -RRB- T_cell_receptor_alpha _ -LRB- TRA -RRB- _ and_delta -LRB- TRD -RRB- genes and genomic organization of the TRA/TRD locus .
17011494	0	TRA-1	78,83	TRA-4	22,27	TRA-1	TRA-4	176548(Tax:6239)	180575(Tax:6239)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. _ elegans .
19906855	0	TRA-1	116,121	xol-1	0,5	TRA-1	xol-1	176548(Tax:6239)	181061(Tax:6239)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	xol-1 , the master sex-switch gene in C. _ elegans , is a transcriptional target of the terminal sex-determining factor TRA-1 .
17011494	0	TRA-4	22,27	TRA-1	78,83	TRA-4	TRA-1	180575(Tax:6239)	176548(Tax:6239)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. _ elegans .
23429285	0	TRADD	20,25	EVER2	0,5	TRADD	EVER2	8717	147138	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	EVER2 protein binds TRADD to promote TNF-a-induced apoptosis .
11222727	0	TRADD	0,5	LMP1	56,60	TRADD	LMP1	8717	9260	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	TRADD domain of Epstein-Barr_virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts .
10409763	0	TRADD	124,129	RIP	164,167	TRADD	RIP	8717	8737	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	The Epstein-Barr_virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting_protein -LRB- RIP -RRB- but does not induce apoptosis or require RIP for NF-kappaB activation .
22510408	0	TRADD	36,41	Ribosomal_protein_S3	0,20	TRADD	Ribosomal protein S3	8717	6188	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ribosomal_protein_S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation .
14730360	0	TRADD	0,5	interferon-gamma	48,64	TRADD	interferon-gamma	8717	3458	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRADD interacts with STAT1-alpha and influences interferon-gamma signaling .
18641653	0	TRADD	16,21	tumor_necrosis_factor_receptor_1	43,75	TRADD	tumor necrosis factor receptor 1	71609(Tax:10090)	21937(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	The function of TRADD in signaling through tumor_necrosis_factor_receptor_1 and TRIF-dependent Toll-like receptors .
18641654	0	TRADD	12,17	tumor_necrosis_factor_receptor_1	21,53	TRADD	tumor necrosis factor receptor 1	71609(Tax:10090)	21937(Tax:10090)	Gene	Gene	Function|nmod|START_ENTITY Function|nmod|signaling signaling|amod|END_ENTITY	Function of TRADD in tumor_necrosis_factor_receptor_1 signaling and in TRIF-dependent inflammatory responses .
25158810	0	TRAF-1	53,59	Tumour_necrosis_factor_receptor-associated_factor-1	0,51	TRAF-1	Tumour necrosis factor receptor-associated factor-1	7185	7185	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tumour_necrosis_factor_receptor-associated_factor-1 -LRB- TRAF-1 -RRB- expression is increased in renal_cell_carcinoma patient serum but decreased in cancer tissue compared with normal : potential biomarker significance .
22945920	0	TRAF-interacting_protein	0,24	IFN-b	53,58	TRAF-interacting protein	IFN-b	10293	3456	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	TRAF-interacting_protein -LRB- TRIP -RRB- negatively regulates IFN-b production and antiviral response by promoting proteasomal degradation of TANK-binding_kinase_1 .
17927961	0	TRAF-interacting_protein	63,87	TRIP	89,93	TRAF-interacting protein	TRIP	22036(Tax:10090)	22036(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Early embryonic_lethality caused by targeted disruption of the TRAF-interacting_protein -LRB- TRIP -RRB- gene .
12502848	0	TRAF1	0,5	JNK	33,36	TRAF1	JNK	7185	5599	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr_virus-encoded latent infection membrane protein 1 but not CD40 .
16891304	1	TRAF1	104,109	MALT1	49,54	TRAF1	MALT1	7185	10892	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2 .
17405906	0	TRAF1	28,33	NF-kappaB2	0,10	TRAF1	NF-kappaB2	22029(Tax:10090)	18034(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	NF-kappaB2 mutation targets TRAF1 to induce lymphomagenesis .
10544244	0	TRAF1	0,5	TNF	11,14	TRAF1	TNF	7185	7124	Gene	Gene	regulator|nsubj|START_ENTITY regulator|compound|END_ENTITY	TRAF1 is a TNF inducible regulator of NF-kappaB activation .
12890376	0	TRAF1	61,66	latent_membrane_protein_1	27,52	TRAF1	latent membrane protein 1	7185	9260	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epstein-Barr_virus encoded latent_membrane_protein_1 induces TRAF1 expression to promote anti-apoptosis activity via NF-kappaB signaling pathway in nasopharyngeal_carcinoma .
9300817	0	TRAF1	79,84	tumour_necrosis_factor_receptor-associated_factor_1	26,77	TRAF1	tumour necrosis factor receptor-associated factor 1	7185	7185	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Organization of the human tumour_necrosis_factor_receptor-associated_factor_1 -LRB- TRAF1 -RRB- gene and mapping to chromosome 9q33-34 .
18952128	0	TRAF2	36,41	A20	24,27	TRAF2	A20	7186	7128	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation .
9774977	0	TRAF2	45,50	ASK1	0,4	TRAF2	ASK1	7186	4217	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	ASK1 is essential for JNK/SAPK activation by TRAF2 .
9153189	0	TRAF2	76,81	ATAR	0,4	TRAF2	ATAR	7186	8764	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	ATAR , a novel tumor necrosis factor receptor family member , signals through TRAF2 and TRAF5 .
9037063	0	TRAF2	81,86	CD30	0,4	TRAF2	CD30	7186	943	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|induction induction|nummod|END_ENTITY	CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2 .
12958312	0	TRAF2	106,111	CD40	115,119	TRAF2	CD40	22030(Tax:10090)	21939(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- - deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling .
11112773	0	TRAF2	27,32	Caveolin-1	0,10	TRAF2	Caveolin-1	7186	857	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors .
24572254	0	TRAF2	49,54	Dysferlin	0,9	TRAF2	Dysferlin	22030(Tax:10090)	26903(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial_ischemia reperfusion injury .
19243468	0	TRAF2	21,26	HSP70	0,5	TRAF2	HSP70	7186	3308	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon_cancer cells .
26610752	0	TRAF2	0,5	JNK	15,18	TRAF2	JNK	311786(Tax:10116)	116554(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	TRAF2 mediates JNK and STAT3 activation in response to IL-1b and IFNy and facilitates apoptotic death of insulin-producing b-cells .
9390693	0	TRAF2	0,5	JNK	23,26	TRAF2	JNK	7186	5599	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival .
19385034	0	TRAF2	61,66	JNK-binding_protein_1	0,21	TRAF2	JNK-binding protein 1	7186	23005	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	JNK-binding_protein_1 regulates NF-kappaB activation through TRAF2 and TAK1 .
25889878	0	TRAF2	74,79	MMP-9	26,31	TRAF2	MMP-9	22030(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
25889878	0	TRAF2	74,79	MMP-9	26,31	TRAF2	MMP-9	22030(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
21339290	0	TRAF2	69,74	RIPK1	25,30	TRAF2	RIPK1	7186	8737	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	In TNF-stimulated cells , RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1 , which limits induction of non-canonical NF-kappaB and activation of caspase-8 .
26826208	0	TRAF2	69,74	RIPK1	25,30	TRAF2	RIPK1	7186	8737	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	In TNF-stimulated cells , RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1 , which limits induction of non-canonical NF-kB and activation of caspase-8 .
20184394	0	TRAF2	53,58	TACI	0,4	TRAF2	TACI	7186	23495	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling .
23998902	0	TRAF2	24,29	TNF-a	48,53	TRAF2	TNF-a	7186	7124	Gene	Gene	contribute|nsubj|START_ENTITY contribute|nmod|resistance resistance|amod|END_ENTITY	The E3 ubiquitin ligase TRAF2 can contribute to TNF-a resistance in FLT3-ITD-positive AML cells .
25889878	0	TRAF2	74,79	TNF-a	12,17	TRAF2	TNF-a	22030(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
25889878	0	TRAF2	74,79	TNF-a	12,17	TRAF2	TNF-a	22030(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Erratum to : TNF-a induces MMP-9 expression and soluble ICAM-1 release via TRAF2 , c-Src , MAPKs and NF-kB in osteoblast-like MC3T3-E1 cells .
24318359	0	TRAF2	2,7	TNFR2	38,43	TRAF2	TNFR2	7186	7133	Gene	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1 .
22042853	0	TRAF2	51,56	TNF_receptor-associated_factor_2	17,49	TRAF2	TNF receptor-associated factor 2	22030(Tax:10090)	22030(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Crucial role for TNF_receptor-associated_factor_2 -LRB- TRAF2 -RRB- in regulating NFkB2 signaling that contributes to autoimmunity .
22029577	0	TRAF2	45,50	Ubiquitin-specific_protease_4	0,29	TRAF2	Ubiquitin-specific protease 4	7186	7375	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Ubiquitin-specific_protease_4 -LRB- USP4 -RRB- targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFa-induced cancer cell migration .
18190721	0	TRAF2	15,20	cellular_FLICE-like_inhibitory_protein	44,82	TRAF2	cellular FLICE-like inhibitory protein	7186	8837	Gene	Gene	START_ENTITY|nmod|form form|nmod|END_ENTITY	Association of TRAF2 with the short form of cellular_FLICE-like_inhibitory_protein prevents TNFR1-mediated apoptosis .
12571250	0	TRAF2	26,31	lymphotoxin_beta_receptor	61,86	TRAF2	lymphotoxin beta receptor	7186	4055	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Endogenous association of TRAF2 , TRAF3 , cIAP1 , and Smac with lymphotoxin_beta_receptor reveals a novel mechanism of apoptosis .
19586614	0	TRAF2	63,68	mixed_lineage_kinase_3	31,53	TRAF2	mixed lineage kinase 3	7186	4296	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|activation activation|nmod|END_ENTITY	Cytokine-induced activation of mixed_lineage_kinase_3 requires TRAF2 and TRAF6 .
23188828	0	TRAF2	58,63	ribosomal_protein_S3	19,39	TRAF2	ribosomal protein S3	7186	6188	Gene	Gene	mediates|compound|START_ENTITY mediates|amod|END_ENTITY	Phosphorylation of ribosomal_protein_S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung_cancer cells .
20138174	0	TRAF3	21,26	BS69	0,4	TRAF3	BS69	7187	10771	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	BS69 cooperates with TRAF3 in the regulation of Epstein-Barr_virus-derived LMP1/CTAR1-induced NF-kappaB activation .
26755589	0	TRAF3	8,13	CREB	41,45	TRAF3	CREB	7187	1385	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Nuclear TRAF3 is a negative regulator of CREB in B cells .
9242637	0	TRAF3	65,70	LMP-1	87,92	TRAF3	LMP-1	7187	9260	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Localization of the major NF-kappaB-activating site and the sole TRAF3 binding site of LMP-1 defines two distinct signaling motifs .
8950992	0	TRAF3	114,119	LMP1	93,97	TRAF3	LMP1	7187	9260	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr_Virus-encoded LMP1 : involvement of TRAF3 as a common mediator .
24391649	0	TRAF3	31,36	NF-kB2	55,61	TRAF3	NF-kB2	7187	4791	Gene	Gene	Relationship|nmod|START_ENTITY END_ENTITY|nsubj|Relationship	A Complex Relationship between TRAF3 and Non-Canonical NF-kB2 Activation in B Lymphocytes .
20185819	0	TRAF3	0,5	lymphotoxin_beta_receptor	75,100	TRAF3	lymphotoxin beta receptor	7187	4055	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin_beta_receptor .
27026194	0	TRAF3	37,42	osteopontin	14,25	TRAF3	osteopontin	22031(Tax:10090)	20750(Tax:10090)	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response .
24993240	0	TRAF4	0,5	Akt	68,71	TRAF4	Akt	9618	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	TRAF4 promotes tumorigenesis of breast_cancer through activation of Akt .
16157600	0	TRAF4	38,43	JNK	48,51	TRAF4	JNK	9618	5599	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	MEKK4 is an effector of the embryonic TRAF4 for JNK activation .
25976502	0	TRAF4	95,100	MicroRNA-370	0,12	TRAF4	MicroRNA-370	9618	442915	Gene	Gene	downregulating|dobj|START_ENTITY inhibits|advcl|downregulating inhibits|nsubj|END_ENTITY	MicroRNA-370 inhibits the progression of non-small_cell_lung_cancer by downregulating oncogene TRAF4 .
12023963	0	TRAF4	15,20	c-Jun_N-terminal_kinase	48,71	TRAF4	c-Jun N-terminal kinase	9618	5599	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of TRAF4 in oxidative activation of c-Jun_N-terminal_kinase .
22460559	0	TRAF4	106,111	tumor_necrosis_factor-a	68,91	TRAF4	tumor necrosis factor-a	9618	7124	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Divergent effects of p47 -LRB- phox -RRB- phosphorylation at S303-4 or S379 on tumor_necrosis_factor-a signaling via TRAF4 and MAPK in endothelial cells .
8790348	0	TRAF5	0,5	CD40	89,93	TRAF5	CD40	7188	958	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	TRAF5 , a novel tumor necrosis factor receptor-associated factor family protein , mediates CD40 signaling .
20161788	0	TRAF5	0,5	MAVS	32,36	TRAF5	MAVS	7188	57506	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	TRAF5 is a downstream target of MAVS in antiviral innate immune signaling .
16920630	0	TRAF6	48,53	Caspase-8	0,9	TRAF6	Caspase-8	7189	841	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Caspase-8 regulation by direct interaction with TRAF6 in T_cell_receptor-induced NF-kappaB activation .
23564640	0	TRAF6	86,91	Cezanne	0,7	TRAF6	Cezanne	22034(Tax:10090)	229603(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination .
20634198	0	TRAF6	0,5	DJ-1	49,53	TRAF6	DJ-1	7189	11315	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson 's _ disease brains .
21078302	0	TRAF6	25,30	Glutaredoxin-1	0,14	TRAF6	Glutaredoxin-1	222344	2745	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Glutaredoxin-1 regulates TRAF6 activation and the IL-1 receptor/TLR4 signalling .
23722539	0	TRAF6	0,5	HIF-1a	32,38	TRAF6	HIF-1a	7189	3091	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	TRAF6 upregulates expression of HIF-1a and promotes tumor angiogenesis .
10882101	0	TRAF6	85,90	IL-1	98,102	TRAF6	IL-1	7189	3552	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	TAB2 , a novel adaptor protein , mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway .
12496252	0	TRAF6	198,203	IL-1	41,45	TRAF6	IL-1	7189	3552	Gene	Gene	complex|dep|START_ENTITY IRAK-tumor_necrosis_factor_receptor-associated_factor_6|xcomp|complex required|dep|IRAK-tumor_necrosis_factor_receptor-associated_factor_6 required|nmod|interleukin-1 interleukin-1|appos|END_ENTITY	Pellino_1 is required for interleukin-1 -LRB- IL-1 -RRB- - mediated signaling through its interaction with the IL-1_receptor-associated_kinase_4 -LRB- IRAK4 -RRB- - IRAK-tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- complex .
16371247	0	TRAF6	0,5	IL-1	58,62	TRAF6	IL-1	7189	3552	Gene	Gene	kinase|nsubj|START_ENTITY kinase|ccomp|regulates regulates|nmod|END_ENTITY	TRAF6 and Src kinase activity regulates Cot activation by IL-1 .
18950704	0	TRAF6	72,77	IL-1	16,20	TRAF6	IL-1	7189	3553	Gene	Gene	interacting|nmod|START_ENTITY activation|advcl|interacting IKK|acl|activation IKK|compound|END_ENTITY	HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination .
17287209	0	TRAF6	8,13	MALT1	30,35	TRAF6	MALT1	7189	10892	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions .
16452479	0	TRAF6	85,90	NFkappaB	0,8	TRAF6	NFkappaB	7189	4790	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|signaling signaling|compound|END_ENTITY	NFkappaB signaling is induced by the oncoprotein Tio through direct interaction with TRAF6 .
17878161	0	TRAF6	100,105	NFkappaB	73,81	TRAF6	NFkappaB	7189	4790	Gene	Gene	ubiquitination|compound|START_ENTITY activation|nmod|ubiquitination END_ENTITY|nmod|activation	IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination .
19112497	0	TRAF6	0,5	NFkappaB	55,63	TRAF6	NFkappaB	7189	4790	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL .
20079715	0	TRAF6	21,26	NUMBL	0,5	TRAF6	NUMBL	7189	9253	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	NUMBL interacts with TRAF6 and promotes the degradation of TRAF6 .
25280943	0	TRAF6	0,5	Notch	30,35	TRAF6	Notch	31746(Tax:7227)	31293(Tax:7227)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	TRAF6 is a novel regulator of Notch signaling in Drosophila_melanogaster .
18758450	0	TRAF6	37,42	TGF-beta	11,19	TRAF6	TGF-beta	7189	7040	Gene	Gene	engages|dobj|START_ENTITY engages|nsubj|receptor receptor|compound|END_ENTITY	The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner .
18922473	0	TRAF6	0,5	TGF-beta	61,69	TRAF6	TGF-beta	7189	7040	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta .
12566447	0	TRAF6	108,113	TIFA	18,22	TRAF6	TIFA	7189	92610	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Identification of TIFA as an adapter protein that links tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- to interleukin-1 _ -LRB- IL-1 -RRB- _ receptor-associated_kinase-1 -LRB- IRAK-1 -RRB- in IL-1 receptor signaling .
19592497	0	TRAF6	48,53	TIRAP	25,30	TRAF6	TIRAP	22034(Tax:10090)	117149(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	MyD88 adapter-like -LRB- Mal -RRB- / TIRAP interaction with TRAF6 is critical for TLR2 - and TLR4-mediated NF-kappaB proinflammatory responses .
24812060	0	TRAF6	46,51	TRAM	26,30	TRAF6	TRAM	7189	353376	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 .
16230348	0	TRAF6	137,142	cylindromatosis	21,36	TRAF6	cylindromatosis	7189	1540	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The tumor suppressor cylindromatosis -LRB- CYLD -RRB- acts as a negative regulator for toll-like_receptor_2 signaling via negative cross-talk with TRAF6 AND TRAF7 .
21155952	0	TRAF6	0,5	interleukin-2	51,64	TRAF6	interleukin-2	22034(Tax:10090)	16183(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling .
18710948	0	TRAF6	0,5	latent_membrane_protein_1	160,185	TRAF6	latent membrane protein 1	7189	9260	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent_membrane_protein_1 .
25700345	0	TRAF6	0,5	p38	46,49	TRAF6	p38	7189	1432	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	TRAF6 is required for the GM-CSF-induced JNK , p38 and Akt activation .
25992615	0	TRAFD1	0,6	Plekhm1	30,37	TRAFD1	Plekhm1	10906	9842	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	TRAFD1 -LRB- FLN29 -RRB- Interacts with Plekhm1 and Regulates Osteoclast Acidification and Resorption .
16888034	0	TRAG-3	42,48	CD4	12,15	TRAG-3	CD4	102723547	920	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Spontaneous CD4 + T cell responses against TRAG-3 in patients with melanoma and breast_cancers .
15580499	0	TRAG-3	99,105	Taxol_resistance-associated_gene-3	63,97	TRAG-3	Taxol resistance-associated gene-3	102723547	102723547	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Spontaneous T-cell responses against peptides derived from the Taxol_resistance-associated_gene-3 -LRB- TRAG-3 -RRB- protein in cancer patients .
22345097	0	TRAIL	77,82	API-1	24,29	TRAIL	API-1	8743	329	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition .
9754559	0	TRAIL	27,32	APO2_ligand	15,26	TRAIL	APO2 ligand	8743	8743	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of APO2_ligand / TRAIL in activation-induced death of Jurkat and human peripheral blood T cells .
12902978	0	TRAIL	42,47	Bax	62,65	TRAIL	Bax	8743	581	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase_9-negative or Bcl-xL overexpressing cells .
14715264	0	TRAIL	33,38	Bcl-xL	95,101	TRAIL	Bcl-xL	8743	598	Gene	Gene	Sensitization|acl|START_ENTITY Sensitization|dep|role role|nmod|down-regulation down-regulation|amod|END_ENTITY	Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone_deacetylase : role of Bcl-xL down-regulation .
21683075	0	TRAIL	51,56	Bcl-xL	98,104	TRAIL	Bcl-xL	8743	598	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Oxaliplatin sensitizes human colon_cancer cells to TRAIL through JNK-dependent phosphorylation of Bcl-xL .
21699898	0	TRAIL	32,37	Bcl-xL	74,80	TRAIL	Bcl-xL	8743	598	Gene	Gene	sensitivity|compound|START_ENTITY restore|dobj|sensitivity restore|nmod|inactivation inactivation|amod|END_ENTITY	Oxaliplatin uses JNK to restore TRAIL sensitivity in cancer cells through Bcl-xL inactivation .
22898820	0	TRAIL	127,132	Bcl-xL	233,239	TRAIL	Bcl-xL	8743	598	Gene	Gene	cells|nmod|START_ENTITY resistance|nmod|cells confers|dobj|resistance confers|advcl|regulating regulating|dobj|END_ENTITY	The transcription_factor_Wilms_tumor 1 confers resistance in myeloid_leukemia cells against the proapoptotic therapeutic agent TRAIL -LRB- tumor_necrosis_factor_a-related_apoptosis-inducing_ligand -RRB- by regulating the antiapoptotic protein Bcl-xL .
26506422	0	TRAIL	91,96	Bcl-xL	0,6	TRAIL	Bcl-xL	8743	598	Gene	Gene	sensitizes|nmod|START_ENTITY sensitizes|nsubj|inhibition inhibition|amod|END_ENTITY	Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic_cancer cells to TRAIL .
26721202	0	TRAIL	45,50	Bcl-xL	167,173	TRAIL	Bcl-xL	8743	598	Gene	Gene	combination|nmod|START_ENTITY Nrf2|nmod|combination Downregulation|nmod|Nrf2 induces|nsubj|Downregulation induces|dobj|death death|nmod|cells cells|nmod|suppression suppression|nmod|END_ENTITY	Downregulation of Nrf2 by the combination of TRAIL and Valproic_acid induces apoptotic cell death of TRAIL-resistant papillary_thyroid_cancer cells via suppression of Bcl-xL .
23468057	0	TRAIL	33,38	C-Reactive_protein	0,18	TRAIL	C-Reactive protein	8743	1401	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	C-Reactive_protein downregulates TRAIL expression in human peripheral monocytes via an Egr-1-dependent pathway .
11264173	0	TRAIL	0,5	CD4	36,39	TRAIL	CD4	8743	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	TRAIL expression by activated human CD4 -LRB- + -RRB- V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid_leukemia cells .
25367576	0	TRAIL	0,5	CD4	26,29	TRAIL	CD4	8743	920	Gene	Gene	T|nsubj|START_ENTITY T|nsubj|END_ENTITY	TRAIL -LRB- + -RRB- NK Cells Control CD4 -LRB- + -RRB- T Cell Responses during Chronic Viral_Infection to Limit Autoimmunity .
17312109	0	TRAIL	82,87	CD8	56,59	TRAIL	CD8	8743	925	Gene	Gene	produce|dobj|START_ENTITY cells|acl:relcl|produce cells|compound|END_ENTITY	Apoptotic cells induce tolerance by generating helpless CD8 + T cells that produce TRAIL .
21064084	0	TRAIL	51,56	CD8	71,74	TRAIL	CD8	8743	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Enhancement of proliferation and downregulation of TRAIL expression on CD8 + T cells by IL-21 .
21621553	0	TRAIL	90,95	CD8	40,43	TRAIL	CD8	8743	925	Gene	Gene	susceptibility|acl|START_ENTITY diminishing|dobj|susceptibility rescues|advcl|diminishing rescues|dobj|cells cells|compound|END_ENTITY	Interleukin-2 rescues helpless effector CD8 + T cells by diminishing the susceptibility to TRAIL mediated death .
22128144	0	TRAIL	66,71	CD8	25,28	TRAIL	CD8	8743	925	Gene	Gene	expression|amod|START_ENTITY control|nmod|expression regulates|nmod|control regulates|dobj|responses responses|compound|END_ENTITY	Nab2 regulates secondary CD8 + T-cell responses through control of TRAIL expression .
11992615	0	TRAIL	114,119	Caspase-8	0,9	TRAIL	Caspase-8	8743	841	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY sufficient|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand sufficient|nsubj|activation activation|amod|END_ENTITY	Caspase-8 activation is necessary but not sufficient for tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis in the prostatic_carcinoma cell line LNCaP .
26426685	0	TRAIL	24,29	Caspase-8	0,9	TRAIL	Caspase-8	8743	841	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Caspase-8 activation by TRAIL monotherapy predicts responses to IAPi and TRAIL combination treatment in breast_cancer cell lines .
10762627	0	TRAIL	107,112	DR4	42,45	TRAIL	DR4	8743	8797	Gene	Gene	resistance|amod|START_ENTITY associated|nmod|resistance associated|nsubjpass|deletion deletion|nmod|gene gene|compound|END_ENTITY	Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal_cancer cell line is associated with TRAIL resistance .
12831538	0	TRAIL	70,75	DR4	96,99	TRAIL	DR4	8743	8797	Gene	Gene	antibodies|nmod|START_ENTITY set|nmod|antibodies Preparation|nmod|set receptors|nsubj|Preparation receptors|dobj|END_ENTITY	Preparation and characterization of a set of monoclonal antibodies to TRAIL and TRAIL receptors DR4 , DR5 , DcR1 , and DcR2 .
15354201	0	TRAIL	155,160	DR4	18,21	TRAIL	DR4	8743	8797	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY kills|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand kills|nsubj|efficiently efficiently|appos|END_ENTITY	Death_receptor_4 -LRB- DR4 -RRB- efficiently kills breast_cancer cells irrespective of their sensitivity to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- .
15356269	0	TRAIL	31,36	DR4	53,56	TRAIL	DR4	8743	8797	Gene	Gene	death|compound|START_ENTITY regulation|nmod|death receptors|nsubj|regulation receptors|dobj|END_ENTITY	Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle .
15972852	0	TRAIL	116,121	DR4	108,111	TRAIL	DR4	8743	8797	Gene	Gene	resistance|amod|START_ENTITY inducing|nmod|resistance inducing|dobj|receptor receptor|appos|END_ENTITY	Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 -LRB- DR4 -RRB- to TRAIL resistance and ovarian_cancer .
16502485	0	TRAIL	19,24	DR4	96,99	TRAIL	DR4	8743	8797	Gene	Gene	treatment|amod|START_ENTITY expression|compound|treatment expression|nmod|END_ENTITY	The combination of TRAIL treatment and cancer cell selective expression of TRAIL-death receptor DR4 induces cell death in TRAIL-resistant cancer cells .
16529749	0	TRAIL	143,148	DR4	35,38	TRAIL	DR4	8743	3126	Gene	Gene	induces|advcl|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Alpha-tocopheryl_succinate induces DR4 and DR5 expression by a p53-dependent route : implication for sensitisation of resistant cancer cells to TRAIL apoptosis .
17143496	0	TRAIL	37,42	DR4	113,116	TRAIL	DR4	8743	3126	Gene	Gene	combination|nmod|START_ENTITY Phytosphingosine|nmod|combination sensitizes|nsubj|Phytosphingosine sensitizes|xcomp|TRAIL TRAIL|nmod|up-regulation up-regulation|nmod|END_ENTITY	Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5 .
17143496	0	TRAIL	70,75	DR4	113,116	TRAIL	DR4	8743	3126	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Phytosphingosine in combination with TRAIL sensitizes cancer cells to TRAIL through synergistic up-regulation of DR4 and DR5 .
17666396	0	TRAIL	31,36	DR4	86,89	TRAIL	DR4	8743	8797	Gene	Gene	DR5|compound|START_ENTITY mutations|nmod|DR5 inhibit|nsubj|mutations inhibit|dep|signaling signaling|nmod|receptor receptor|compound|END_ENTITY	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding .
17666396	0	TRAIL	58,63	DR4	86,89	TRAIL	DR4	8743	8797	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|receptor receptor|compound|END_ENTITY	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding .
17881904	0	TRAIL	89,94	DR4	160,163	TRAIL	DR4	8743	3126	Gene	Gene	START_ENTITY|nmod|non-SP non-SP|appos|expression expression|nmod|END_ENTITY	Chemotherapy-resistant side-population of colon_cancer cells has a higher sensitivity to TRAIL than the non-SP , a higher expression of c-Myc and TRAIL-receptor DR4 .
19148581	0	TRAIL	91,96	DR4	34,37	TRAIL	DR4	8743	8797	Gene	Gene	sensitizes|nmod|START_ENTITY sensitizes|nsubj|Reactivation Reactivation|nmod|expression expression|appos|END_ENTITY	Reactivation of death_receptor_4 -LRB- DR4 -RRB- expression sensitizes medulloblastoma cell lines to TRAIL .
19305384	0	TRAIL	14,19	DR4	44,47	TRAIL	DR4	8743	8797	Gene	Gene	Expression|nmod|START_ENTITY receptors|nsubj|Expression receptors|dobj|correlates correlates|compound|END_ENTITY	Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks .
20041491	0	TRAIL	85,90	DR4	154,157	TRAIL	DR4	8743	8797	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY tumor_necrosis_factor-related_apoptosis-inducing_ligand|acl:relcl|induced induced|nmod|up-regulations up-regulations|nmod|death_receptor_4 death_receptor_4|appos|END_ENTITY	Ionizing radiation enhances tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis through up-regulations of death_receptor_4 -LRB- DR4 -RRB- and death_receptor_5 -LRB- DR5 -RRB- in human osteosarcoma cells .
20354842	0	TRAIL	0,5	DR4	31,34	TRAIL	DR4	8743	8797	Gene	Gene	signaling|compound|START_ENTITY mediated|nsubjpass|signaling mediated|nmod|END_ENTITY	TRAIL signaling is mediated by DR4 in pancreatic_tumor cells despite the expression of functional DR5 .
21272366	0	TRAIL	14,19	DR4	84,87	TRAIL	DR4	8743	3126	Gene	Gene	resistance|amod|START_ENTITY Modulation|nmod|resistance Modulation|dep|contributions contributions|nmod|END_ENTITY	Modulation of TRAIL resistance in colon_carcinoma cells : different contributions of DR4 and DR5 .
21279373	0	TRAIL	24,29	DR4	54,57	TRAIL	DR4	8743	3126	Gene	Gene	expression|nmod|START_ENTITY receptors|nsubj|expression receptors|dobj|END_ENTITY	Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque_psoriasis .
21769428	0	TRAIL	77,82	DR4	18,21	TRAIL	DR4	8743	8797	Gene	Gene	sensitivity|acl|START_ENTITY accounts|nmod|sensitivity accounts|nsubj|Redistribution Redistribution|nmod|END_ENTITY	Redistribution of DR4 and DR5 in lipid rafts accounts for the sensitivity to TRAIL in NSCLC cells .
22401174	0	TRAIL	0,5	DR4	18,21	TRAIL	DR4	8743	3126	Gene	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	TRAIL receptor I -LRB- DR4 -RRB- polymorphisms C626G and A683C are associated with an increased risk for hepatocellular_carcinoma -LRB- HCC -RRB- in HCV-infected patients .
22802267	0	TRAIL	10,15	DR4	48,51	TRAIL	DR4	8743	3126	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|4 4|nmod|complexes complexes|compound|END_ENTITY	Targeting TRAIL death receptor 4 with trivalent DR4 Atrimer complexes .
23686163	0	TRAIL	97,102	DR4	85,88	TRAIL	DR4	8743	8797	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Notch inhibition restores TRAIL-mediated apoptosis via AP1-dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231_breast_cancer cells .
24661673	0	TRAIL	15,20	DR4	73,76	TRAIL	DR4	8743	8797	Gene	Gene	resistance|amod|START_ENTITY Development|nmod|resistance Development|nmod|hypermethylation hypermethylation|nmod|island island|compound|END_ENTITY	Development of TRAIL resistance by radiation-induced hypermethylation of DR4 CpG island in recurrent laryngeal_squamous_cell_carcinoma .
25310712	0	TRAIL	15,20	DR4	144,147	TRAIL	DR4	8743	8797	Gene	Gene	Combination|nmod|START_ENTITY shifted|nsubj|Combination shifted|nmod|internalization internalization|nmod|END_ENTITY	Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4 .
25310712	0	TRAIL	15,20	DR4	70,73	TRAIL	DR4	8743	8797	Gene	Gene	Combination|nmod|START_ENTITY shifted|nsubj|Combination shifted|nmod|receptor receptor|nummod|DR5 DR5|compound|END_ENTITY	Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4 .
25364476	0	TRAIL	100,105	DR4	34,37	TRAIL	DR4	8743	8797	Gene	Gene	sensitivity|amod|START_ENTITY Identification|nmod|sensitivity Identification|nmod|END_ENTITY	Identification of death receptors DR4 and DR5 in HTB-12 astrocytoma cell lines and determination of TRAIL sensitivity .
25482930	0	TRAIL	13,18	DR4	0,3	TRAIL	DR4	8743	8797	Gene	Gene	variants|amod|START_ENTITY variants|nummod|END_ENTITY	DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic_cancer .
25482930	0	TRAIL	64,69	DR4	0,3	TRAIL	DR4	8743	8797	Gene	Gene	efficacious|nmod|START_ENTITY efficacious|nsubj|variants variants|nummod|END_ENTITY	DR4 specific TRAIL variants are more efficacious than wild-type TRAIL in pancreatic_cancer .
26238205	0	TRAIL	42,47	DR4	10,13	TRAIL	DR4	8743	3126	Gene	Gene	methylation|nmod|START_ENTITY methylation|compound|END_ENTITY	Effect of DR4 promoter methylation on the TRAIL - induced apoptosis in lung_squamous_carcinoma cell .
26518902	0	TRAIL	81,86	DR4	108,111	TRAIL	DR4	8743	8797	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Genetic variants in the tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- and death_receptor -LRB- DR4 -RRB- genes contribute to susceptibility to colorectal_cancer in pakistani population .
12207174	0	TRAIL	57,62	DR5	95,98	TRAIL	DR5	8743	8795	Gene	Gene	mediated|dep|START_ENTITY mediated|nsubj|death_receptor_5 death_receptor_5|appos|END_ENTITY	Tumor_necrosis_factor-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- up-regulates death_receptor_5 -LRB- DR5 -RRB- mediated by NFkappaB activation in epithelial derived cell lines .
15987718	0	TRAIL	77,82	DR5	177,180	TRAIL	DR5	8743	8795	Gene	Gene	ligand|appos|START_ENTITY necrosis|dep|ligand necrosis|dep|apoptosis apoptosis|nmod|upregulation upregulation|nmod|death_receptor_5 death_receptor_5|appos|END_ENTITY	Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced apoptosis through reactive oxygen species-mediated upregulation of death_receptor_5 -LRB- DR5 -RRB- .
16357524	0	TRAIL	88,93	DR5	102,105	TRAIL	DR5	8743	8795	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nummod|END_ENTITY	Adenovirus E1A reverses the resistance of normal primary human lung fibroblast cells to TRAIL through DR5 upregulation and caspase_8-dependent pathway .
16452234	0	TRAIL	81,86	DR5	198,201	TRAIL	DR5	8743	8795	Gene	Gene	ligand|appos|START_ENTITY necrosis|dep|ligand sensitizes|dobj|necrosis sensitizes|nmod|up-regulation up-regulation|nmod|END_ENTITY	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5 .
16613838	0	TRAIL	77,82	DR5	128,131	TRAIL	DR5	8743	8795	Gene	Gene	sensitizes|appos|START_ENTITY sensitizes|dep|apoptosis apoptosis|nmod|END_ENTITY	Curcumin sensitizes tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis through CHOP-independent DR5 upregulation .
17666396	0	TRAIL	58,63	DR5	46,49	TRAIL	DR5	8743	8795	Gene	Gene	signaling|nsubj|START_ENTITY inhibit|dep|signaling inhibit|nsubj|mutations mutations|nmod|END_ENTITY	Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding .
18476767	0	TRAIL	0,5	DR5	133,136	TRAIL	DR5	8743	8795	Gene	Gene	adenovirus|amod|START_ENTITY triggers|nsubj|adenovirus triggers|dobj|apoptosis apoptosis|nmod|END_ENTITY	TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60 / Vinc cells preferentially through death receptor DR5 .
18483298	0	TRAIL	67,72	DR5	82,85	TRAIL	DR5	8743	8795	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Proteasome inhibitor PS-341 -LRB- VELCADE -RRB- induces stabilization of the TRAIL receptor DR5 mRNA through the 3 ' - untranslated region .
19577358	0	TRAIL	75,80	DR5	143,146	TRAIL	DR5	8743	8795	Gene	Gene	ligand|appos|START_ENTITY ligand|acl:relcl|induced induced|nmod|up-regulation up-regulation|nmod|death_receptor_5 death_receptor_5|appos|END_ENTITY	Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced apoptosis through up-regulation of death_receptor_5 -LRB- DR5 -RRB- in human sarcoma_HOS cells and human colon_cancer HCT116 cells .
20041491	0	TRAIL	85,90	DR5	181,184	TRAIL	DR5	8743	8795	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY tumor_necrosis_factor-related_apoptosis-inducing_ligand|acl:relcl|induced induced|nmod|up-regulations up-regulations|nmod|death_receptor_4 death_receptor_4|appos|END_ENTITY	Ionizing radiation enhances tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis through up-regulations of death_receptor_4 -LRB- DR4 -RRB- and death_receptor_5 -LRB- DR5 -RRB- in human osteosarcoma cells .
20103630	0	TRAIL	38,43	DR5	12,15	TRAIL	DR5	8743	8795	Gene	Gene	pathway|amod|START_ENTITY activate|dobj|pathway activate|nsubj|peptides peptides|compound|END_ENTITY	Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity .
20159939	0	TRAIL	141,146	DR5	258,261	TRAIL	DR5	8743	8795	Gene	Gene	ligand|appos|START_ENTITY cells|dep|ligand cells|dep|death_receptor_5 death_receptor_5|appos|END_ENTITY	The synthetic cannabinoid WIN_55 ,212 -2 sensitizes hepatocellular_carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced apoptosis by activating p8/CCAAT/enhancer _ binding_protein_homologous_protein -LRB- CHOP -RRB- / death_receptor_5 -LRB- DR5 -RRB- axis .
20354842	0	TRAIL	0,5	DR5	98,101	TRAIL	DR5	8743	8795	Gene	Gene	signaling|compound|START_ENTITY mediated|nsubjpass|signaling mediated|nmod|expression expression|nmod|END_ENTITY	TRAIL signaling is mediated by DR4 in pancreatic_tumor cells despite the expression of functional DR5 .
20840533	0	TRAIL	57,62	DR5	88,91	TRAIL	DR5	8743	8795	Gene	Gene	Tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY END_ENTITY|nsubj|Tumor_necrosis_factor-related_apoptosis-inducing_ligand	Tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- and its death_receptor -LRB- DR5 -RRB- in Peyronie 's _ disease .
21152876	0	TRAIL	110,115	DR5	187,190	TRAIL	DR5	8743	8795	Gene	Gene	cells|acl|START_ENTITY sensitizes|dobj|cells sensitizes|advcl|upregulation upregulation|nmod|END_ENTITY	Cisplatin sensitizes human hepatocellular_carcinoma cells , but not hepatocytes and mesenchymal stem cells , to TRAIL within a therapeutic window partially depending on the upregulation of DR5 .
21697087	0	TRAIL	211,216	DR5	81,84	TRAIL	DR5	8743	8795	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY sensitizes|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand sensitizes|nsubj|Modulation Modulation|nmod|binding_protein_homologous_protein binding_protein_homologous_protein|dep|expression expression|compound|END_ENTITY	Modulation of CCAAT/enhancer _ binding_protein_homologous_protein -LRB- CHOP -RRB- - dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- .
21822052	0	TRAIL	136,141	DR5	42,45	TRAIL	DR5	8743	8795	Gene	Gene	apoptosis|amod|START_ENTITY contribute|nmod|apoptosis contribute|nsubj|inhibition inhibition|nmod|END_ENTITY	Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax -LRB- GX15-070 -RRB- contribute in the sensitization of B-NHL cells to TRAIL apoptosis .
21877938	0	TRAIL	19,24	DR5	103,106	TRAIL	DR5	8743	8795	Gene	Gene	pathway|amod|START_ENTITY restores|dobj|pathway restores|nmod|up-regulation up-regulation|nmod|END_ENTITY	Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP .
22020938	0	TRAIL	150,155	DR5	71,74	TRAIL	DR5	8743	8795	Gene	Gene	ligand|appos|START_ENTITY factor|dep|ligand limits|dobj|factor limits|nsubj|localization localization|nmod|death_receptor_5 death_receptor_5|appos|END_ENTITY	Importin b1 protein-mediated nuclear localization of death_receptor_5 -LRB- DR5 -RRB- limits DR5/tumor necrosis factor -LRB- TNF -RRB- - related apoptosis-inducing ligand -LRB- TRAIL -RRB- - induced cell death of human tumor cells .
22419388	0	TRAIL	90,95	DR5	111,114	TRAIL	DR5	22035(Tax:10090)	21933(Tax:10090)	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	Induction of proapoptotic antibodies to triple-negative_breast_cancer by vaccination with TRAIL death receptor DR5 DNA .
23224239	0	TRAIL	53,58	DR5	113,116	TRAIL	DR5	8743	8795	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5 .
23247197	0	TRAIL	126,131	DR5	153,156	TRAIL	DR5	8743	8795	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP .
24866585	0	TRAIL	65,70	DR5	107,110	TRAIL	DR5	8743	8795	Gene	Gene	triple-negative_breast_cancer|nmod|START_ENTITY upregulation|amod|triple-negative_breast_cancer upregulation|compound|END_ENTITY	YM155 sensitizes triple-negative_breast_cancer to membrane-bound TRAIL through p38 MAPK - and CHOP-mediated DR5 upregulation .
24939851	0	TRAIL	216,221	DR5	285,288	TRAIL	DR5	8743	8795	Gene	Gene	ligand|appos|START_ENTITY factor|dep|ligand necrosis|dobj|factor reticulum|acl:relcl|necrosis Role|nmod|reticulum mediated|nsubj|Role mediated|nmod|up-regulation up-regulation|nmod|death_receptor_5 death_receptor_5|appos|END_ENTITY	Role of activating_transcription_factor_3 -LRB- ATF3 -RRB- in endoplasmic reticulum -LRB- ER -RRB- stress-induced sensitization of p53-deficient human colon_cancer cells to tumor necrosis factor -LRB- TNF -RRB- - related apoptosis-inducing ligand -LRB- TRAIL -RRB- - mediated apoptosis through up-regulation of death_receptor_5 -LRB- DR5 -RRB- by zerumbone and celecoxib .
25310712	0	TRAIL	15,20	DR5	77,80	TRAIL	DR5	8743	8795	Gene	Gene	Combination|nmod|START_ENTITY shifted|nsubj|Combination shifted|nmod|receptor receptor|nummod|END_ENTITY	Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4 .
25882551	0	TRAIL	15,20	DR5	38,41	TRAIL	DR5	8743	8795	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|clustering clustering|compound|END_ENTITY	Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic_lymphoma U937 cells .
26074143	0	TRAIL	29,34	DR5	97,100	TRAIL	DR5	8743	8795	Gene	Gene	cytotoxicity|amod|START_ENTITY enhances|dobj|cytotoxicity enhances|nmod|cells cells|nmod|END_ENTITY	RAD001 -LRB- everolimus -RRB- enhances TRAIL cytotoxicity in human leukemic Jurkat T cells by upregulating DR5 .
26385392	0	TRAIL	133,138	DR5	73,76	TRAIL	DR5	8743	8795	Gene	Gene	encoding|dobj|START_ENTITY encoding|nsubj|cytotoxicity cytotoxicity|nmod|antibody antibody|compound|END_ENTITY	Targeted radiotherapy potentiates the cytotoxicity of a novel anti-human DR5 monoclonal antibody and the adenovirus encoding soluble TRAIL in prostate_cancer .
26547077	0	TRAIL	54,59	DR5	63,66	TRAIL	DR5	8743	8795	Gene	Gene	START_ENTITY|nmod|Receptor Receptor|compound|END_ENTITY	Mutations Enhancing Selectivity of Antitumor Cytokine TRAIL to DR5 Receptor Increase Its Cytotoxicity against Tumor Cells .
26577955	0	TRAIL	189,194	DR5	45,48	TRAIL	DR5	8743	8795	Gene	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced associated|nmod|apoptosis associated|nsubj|expression expression|appos|END_ENTITY	The enhanced expression of death receptor 5 -LRB- DR5 -RRB- mediated by HBV X protein through NF-kappaB pathway is associated with cell apoptosis induced by -LRB- TNF-a related apoptosis inducing ligand -RRB- TRAIL in hepatoma cells .
26952193	0	TRAIL	48,53	DR5	9,12	TRAIL	DR5	8743	8795	Gene	Gene	capacity|nmod|START_ENTITY capacity|compound|END_ENTITY	Enhanced DR5 binding capacity of nanovectorized TRAIL compared to its cytotoxic version by affinity chromatography and molecular docking studies .
27053682	0	TRAIL	19,24	Death_Receptor_4	51,67	TRAIL	Death Receptor 4	8743	8797	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	HuR Contributes to TRAIL Resistance by Restricting Death_Receptor_4 Expression in Pancreatic_Cancer Cells .
25747387	0	TRAIL	27,32	ERK	47,50	TRAIL	ERK	8743	5594	Gene	Gene	START_ENTITY|advcl|activating activating|dobj|END_ENTITY	Msi1 confers resistance to TRAIL by activating ERK in liver_cancer cells .
18239851	0	TRAIL	0,5	ERK1/2	84,90	TRAIL	ERK1/2	8743	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2 .
17264490	0	TRAIL	66,71	Fas_ligand	12,22	TRAIL	Fas ligand	8743	356	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of Fas_ligand and TNF-related apoptosis-inducing ligand -LRB- TRAIL -RRB- in the ocular immune response .
18317451	0	TRAIL	62,67	Hdm2	99,103	TRAIL	Hdm2	8743	4193	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Protein_kinase_C_epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53 .
19376111	0	TRAIL	39,44	Homer1	0,6	TRAIL	Homer1	8743	9456	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Homer1 regulates the susceptibility to TRAIL .
23587601	0	TRAIL	0,5	Hsp47	59,64	TRAIL	Hsp47	8743	871	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	TRAIL regulates collagen production through HSF1-dependent Hsp47 expression in activated hepatic stellate cells .
12097384	0	TRAIL	66,71	IFN-alpha	144,153	TRAIL	IFN-alpha	8743	3439	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Tumor-infiltrating CD4 + T lymphocytes express APO2_ligand -LRB- APO2L -RRB- / TRAIL upon specific stimulation with autologous lung_carcinoma cells : role of IFN-alpha on APO2L/TRAIL expression and - mediated cytotoxicity .
21802664	0	TRAIL	56,61	IFN-y	40,45	TRAIL	IFN-y	8743	3458	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Synergy between TLR3 and IL-18 promotes IFN-y dependent TRAIL expression in human liver NK cells .
22104728	0	TRAIL	84,89	IFN-y	0,5	TRAIL	IFN-y	8743	3458	Gene	Gene	cells|compound|START_ENTITY apoptosis-sensitisation|nmod|cells leads|nmod|apoptosis-sensitisation leads|nsubj|END_ENTITY	IFN-y combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic_carcinoma cells .
24155891	0	TRAIL	33,38	IL-27	0,5	TRAIL	IL-27	8743	246778	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperation with a TLR3 agonist poly -LRB- I : C -RRB- partly in a TRAIL-dependent manner .
22961755	0	TRAIL	0,5	IL-33	39,44	TRAIL	IL-33	22035(Tax:10090)	77125(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	TRAIL but not FasL and TNFa , regulates IL-33 expression in murine hepatocytes during acute_hepatitis .
23163132	0	TRAIL	34,39	IL8	12,15	TRAIL	IL8	8743	3576	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|dobj|levels	Erratum to `` IL8 and serum soluble TRAIL levels following anti-VEGF monoclonal antibody treatment in patients with metastatic colon_cancer '' -LSB- Clin .
25950488	0	TRAIL	29,34	IPS-1	0,5	TRAIL	IPS-1	8743	57506	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IPS-1 differentially induces TRAIL , BCL2 , BIRC3 and PRKCE in type I interferons-dependent and - independent anticancer activity .
17352408	0	TRAIL	23,28	Insulin	0,7	TRAIL	Insulin	246775(Tax:10116)	3630	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro .
16955144	0	TRAIL	0,5	JNK	24,27	TRAIL	JNK	22035(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver_damage and lethality .
23857473	0	TRAIL	66,71	JNK	123,126	TRAIL	JNK	8743	5599	Gene	Gene	receptors|amod|START_ENTITY receptors|nmod|activation activation|nmod|p38 p38|nmod|END_ENTITY	CAPE promotes TRAIL-induced apoptosis through the upregulation of TRAIL receptors via activation of p38 and suppression of JNK in SK-Hep1 hepatocellular carcinoma cells .
25446254	0	TRAIL	0,5	JNK	16,19	TRAIL	JNK	8743	5599	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TRAIL activates JNK and NF-kB through RIP1-dependent and - independent pathways .
11139340	0	TRAIL	43,48	KILLER/DR5	32,42	TRAIL	KILLER/DR5	8743	8795	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma .
18834856	0	TRAIL	0,5	MMP-9	14,19	TRAIL	MMP-9	8743	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	TRAIL induces MMP-9 expression via ERK activation in human astrocytoma cells .
26721202	0	TRAIL	45,50	Nrf2	18,22	TRAIL	Nrf2	8743	4780	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Downregulation of Nrf2 by the combination of TRAIL and Valproic_acid induces apoptotic cell death of TRAIL-resistant papillary_thyroid_cancer cells via suppression of Bcl-xL .
15270863	0	TRAIL	120,125	Osteoprotegerin	0,15	TRAIL	Osteoprotegerin	8743	4982	Gene	Gene	tumour_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY receptor|nmod|tumour_necrosis_factor-related_apoptosis-inducing_ligand acts|nmod|receptor acts|nsubj|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- acts as an endogenous decoy receptor in tumour_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis of fibroblast-like synovial cells .
16413220	0	TRAIL	90,95	Osteoprotegerin	0,15	TRAIL	Osteoprotegerin	8743	4982	Gene	Gene	ligand|appos|START_ENTITY binds|dobj|ligand binds|nsubj|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- binds with tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- : suppression of TRAIL-induced apoptosis in ameloblastomas .
18338379	0	TRAIL	71,76	Osteoprotegerin	0,15	TRAIL	Osteoprotegerin	8743	4982	Gene	Gene	pathway|amod|START_ENTITY inhibiting|dobj|pathway decreases|advcl|inhibiting decreases|nsubj|END_ENTITY	Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway .
25636966	0	TRAIL	36,41	Osteoprotegerin	12,27	TRAIL	Osteoprotegerin	8743	4982	Gene	Gene	Binding|compound|START_ENTITY Binding|compound|END_ENTITY	Variants of Osteoprotegerin Lacking TRAIL Binding for Therapeutic Bone Remodeling in Osteolytic_Malignancies .
9603945	0	TRAIL	55,60	Osteoprotegerin	0,15	TRAIL	Osteoprotegerin	8743	4982	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL .
27013583	0	TRAIL	29,34	PLAG1	86,91	TRAIL	PLAG1	8743	5324	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	MiR-424 and miR-27a increase TRAIL sensitivity of acute_myeloid_leukemia by targeting PLAG1 .
10958661	0	TRAIL	45,50	RIP	24,27	TRAIL	RIP	8743	8737	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	The death domain kinase RIP is essential for TRAIL -LRB- Apo2L -RRB- - induced activation of IkappaB kinase and c-Jun_N-terminal_kinase .
20063037	0	TRAIL	72,77	TNF-alpha	0,9	TRAIL	TNF-alpha	8743	7124	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	TNF-alpha modulates the migratory response of mesenchymal stem cells to TRAIL .
10364001	0	TRAIL	51,56	TNF-related_apoptosis-inducing_ligand	12,49	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Relation of TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma .
11240708	0	TRAIL	14,19	TNF-related_apoptosis-inducing_ligand	21,58	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression of TRAIL -LRB- TNF-related_apoptosis-inducing_ligand -RRB- receptors in cervical_cancer .
12738989	0	TRAIL	97,102	TNF-related_apoptosis-inducing_ligand	58,95	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cell to cell contact required for bystander effect of the TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- gene .
15539085	0	TRAIL	53,58	TNF-related_apoptosis-inducing_ligand	14,51	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- in megakaryocytes and platelets .
15608694	0	TRAIL	81,86	TNF-related_apoptosis-inducing_ligand	42,79	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Histone deacetylase inhibitors potentiate TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis in lymphoid_malignancies .
16941746	0	TRAIL	69,74	TNF-related_apoptosis-inducing_ligand	30,67	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hydrogen_peroxide upregulates TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- expression in human astroglial cells , and augments apoptosis of T cells .
22202560	0	TRAIL	65,70	TNF-related_apoptosis-inducing_ligand	26,63	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Osteoprotegerin -LRB- OPG -RRB- and TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- levels in malignant_and_benign_pericardial_effusions .
23492758	0	TRAIL	49,54	TNF-related_apoptosis-inducing_ligand	10,47	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- show a long-term stability in the breast milk of mothers of preterm infants .
24771425	0	TRAIL	20,25	TNF-related_apoptosis-inducing_ligand	27,64	TRAIL	TNF-related apoptosis-inducing ligand	22035(Tax:10090)	22035(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Systemic effects of TRAIL -LRB- TNF-related_apoptosis-inducing_ligand -RRB- during acute y-irradiation .
25813908	0	TRAIL	49,54	TNF-related_apoptosis-inducing_ligand	10,47	TRAIL	TNF-related apoptosis-inducing ligand	8743	8743	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Low serum TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- levels are associated with acute ischemic_stroke severity .
10502402	0	TRAIL	7,12	TNF-related_apoptosis_inducing_ligand	14,51	TRAIL	TNF-related apoptosis inducing ligand	22035(Tax:10090)	22035(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Murine TRAIL -LRB- TNF-related_apoptosis_inducing_ligand -RRB- expression induced by T cell activation is blocked by rapamycin , cyclosporin_A , and inhibitors of phosphatidylinositol 3-kinase , protein kinase C , and protein tyrosine kinases : evidence for TRAIL induction via the T cell receptor signaling pathway .
16040132	0	TRAIL	39,44	TNF-related_apoptosis_inducing_ligand	0,37	TRAIL	TNF-related apoptosis inducing ligand	8743	8743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	TNF-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- gene polymorphism in Japanese patients with multiple_sclerosis .
17875785	0	TRAIL	146,151	TRAIL-R1	163,171	TRAIL	TRAIL-R1	8743	8797	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Bortezomib sensitizes non-Hodgkin 's _ lymphoma cells to apoptosis induced by antibodies to tumor necrosis factor related apoptosis-inducing ligand -LRB- TRAIL -RRB- receptors TRAIL-R1 and TRAIL-R2 .
11494138	0	TRAIL	151,156	TRAIL-R2	129,137	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	derivative|amod|START_ENTITY allows|nmod|derivative allows|dobj|activation activation|nmod|END_ENTITY	Differential activation of TRAIL-R1_and _ -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative .
11494138	0	TRAIL	67,72	TRAIL-R2	129,137	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	-2|nmod|START_ENTITY activation|nmod|-2 allows|nsubj|activation allows|dobj|activation activation|nmod|END_ENTITY	Differential activation of TRAIL-R1_and _ -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative .
17922877	0	TRAIL	0,5	TRAIL-R2	124,132	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	signals|nsubj|START_ENTITY signals|xcomp|apoptosis apoptosis|advcl|facilitate facilitate|nsubj|antibodies antibodies|compound|END_ENTITY	TRAIL signals to apoptosis in chronic_lymphocytic_leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2 .
17922877	0	TRAIL	0,5	TRAIL-R2	170,178	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	signals|nsubj|START_ENTITY signals|xcomp|apoptosis apoptosis|advcl|facilitate facilitate|xcomp|signalling signalling|nmod|END_ENTITY	TRAIL signals to apoptosis in chronic_lymphocytic_leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2 .
19079141	0	TRAIL	75,80	TRAIL-R2	111,119	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Inhibition of Aurora_B kinase sensitizes a subset of human glioma cells to TRAIL concomitant with induction of TRAIL-R2 .
24190693	0	TRAIL	64,69	TRAIL-R2	38,46	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Epigenetic and expression analysis of TRAIL-R2 and BCL2 : on the TRAIL to knowledge of apoptosis in ovarian_tumors .
25165876	0	TRAIL	63,68	TRAIL-R2	121,129	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	functions|appos|START_ENTITY functions|dep|role role|nmod|END_ENTITY	Compartmentalization of TNF-related apoptosis-inducing ligand -LRB- TRAIL -RRB- death receptor functions : emerging role of nuclear TRAIL-R2 .
9311998	0	TRAIL	51,56	TRAIL-R2	0,8	TRAIL	TRAIL-R2	8743	8795	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|dep|receptor	TRAIL-R2 : a novel apoptosis-mediating receptor for TRAIL .
9537512	0	TRAIL	28,33	TRUNDD	0,6	TRAIL	TRUNDD	8743	8793	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	TRUNDD , a new member of the TRAIL receptor family that antagonizes TRAIL signalling .
25113506	0	TRAIL	114,119	Urokinase-type_plasminogen_activator_receptor	0,45	TRAIL	Urokinase-type plasminogen activator receptor	8743	5329	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Urokinase-type_plasminogen_activator_receptor regulates apoptotic sensitivity of colon_cancer HCT116 cell line to TRAIL via JNK-p53 pathway .
17050666	0	TRAIL	84,89	X-linked_inhibitor_of_apoptosis_protein	121,160	TRAIL	X-linked inhibitor of apoptosis protein	8743	331	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Constitutively activated nuclear_factor-kappaB , but not induced NF-kappaB , leads to TRAIL resistance by up-regulation of X-linked_inhibitor_of_apoptosis_protein in human cancer cells .
17308080	0	TRAIL	19,24	X-linked_inhibitor_of_apoptosis_protein	102,141	TRAIL	X-linked inhibitor of apoptosis protein	8743	331	Gene	Gene	resistance|amod|START_ENTITY reverses|dobj|resistance reverses|nmod|lines lines|nmod|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Gefitinib reverses TRAIL resistance in human bladder_cancer cell lines via inhibition of AKT-mediated X-linked_inhibitor_of_apoptosis_protein expression .
15126334	0	TRAIL	135,140	XIAP	41,45	TRAIL	XIAP	8743	331	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY modulator|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand modulator|nsubj|inhibitor inhibitor|appos|END_ENTITY	X-linked inhibitor of apoptosis protein -LRB- XIAP -RRB- is a nonredundant modulator of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis in human cancer cells .
16953886	0	TRAIL	110,115	XIAP	28,32	TRAIL	XIAP	100174780(Tax:9615)	442989(Tax:9615)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|down-regulation down-regulation|nmod|END_ENTITY	Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin .
18829553	0	TRAIL	53,58	XIAP	10,14	TRAIL	XIAP	22035(Tax:10090)	11798(Tax:10090)	Gene	Gene	bypasses|nmod|START_ENTITY bypasses|nsubj|END_ENTITY	Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic_cancer growth in vitro and in vivo .
19034449	0	TRAIL	80,85	XIAP	7,11	TRAIL	XIAP	8743	331	Gene	Gene	sensitive|nmod|START_ENTITY sensitive|nsubj|clones clones|compound|END_ENTITY	Stable XIAP knockdown clones of HCT116 colon_cancer cells are more sensitive to TRAIL , taxanes and irradiation in vitro .
19036706	0	TRAIL	46,51	XIAP	15,19	TRAIL	XIAP	22035(Tax:10090)	11798(Tax:10090)	Gene	Gene	cooperate|nmod|START_ENTITY END_ENTITY|ccomp|cooperate	Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute_leukemia cells and overcome Bcl-2-mediated resistance .
19179889	0	TRAIL	142,147	XIAP	53,57	TRAIL	XIAP	8743	331	Gene	Gene	apoptosis|nmod|START_ENTITY responsible|nmod|apoptosis lines|acl:relcl|responsible END_ENTITY|nmod|lines	A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL .
22104728	0	TRAIL	84,89	XIAP	33,37	TRAIL	XIAP	8743	331	Gene	Gene	cells|compound|START_ENTITY apoptosis-sensitisation|nmod|cells leads|nmod|apoptosis-sensitisation leads|nsubj|IFN-y IFN-y|acl|combined combined|advcl|targeting targeting|nmod|END_ENTITY	IFN-y combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic_carcinoma cells .
22508521	0	TRAIL	67,72	XIAP	0,4	TRAIL	XIAP	8743	331	Gene	Gene	sensitivity|compound|START_ENTITY enhances|dobj|sensitivity enhances|nsubj|inhibition inhibition|compound|END_ENTITY	XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory_breast_cancer cells .
22799350	0	TRAIL	80,85	XIAP	53,57	TRAIL	XIAP	8743	331	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of malignant_melanoma by downregulation of XIAP and overexpression of TRAIL with a conditionally replicating oncolytic adenovirus .
25358405	0	TRAIL	51,56	XIAP	65,69	TRAIL	XIAP	8743	331	Gene	Gene	START_ENTITY|nmod|Inhibition Inhibition|compound|END_ENTITY	Embelin Sensitizes Acute Myeloid_Leukemia Cells to TRAIL through XIAP Inhibition and NF-kB Inactivation .
16636669	0	TRAIL	0,5	acid_sphingomyelinase	16,37	TRAIL	acid sphingomyelinase	8743	6609	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TRAIL activates acid_sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis .
24379239	0	TRAIL	14,19	b-catenin	43,52	TRAIL	b-catenin	8743	1499	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of TRAIL receptor expression by b-catenin in colorectal_tumours .
12496481	0	TRAIL	66,71	c-FLIP	124,130	TRAIL	c-FLIP	8743	8837	Gene	Gene	START_ENTITY|dobj|apoptosis apoptosis|acl:relcl|correlates correlates|nmod|loss loss|nmod|expression expression|amod|END_ENTITY	Doxorubicin pretreatment sensitizes prostate_cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression .
18209050	0	TRAIL	53,58	c-FLIP	101,107	TRAIL	c-FLIP	8743	8837	Gene	Gene	confers|nmod|START_ENTITY confers|advcl|regulating regulating|dobj|END_ENTITY	Bone marrow_stroma confers resistance to Apo2_ligand / TRAIL in multiple myeloma in part by regulating c-FLIP .
18790747	0	TRAIL	35,40	c-FLIP	115,121	TRAIL	c-FLIP	8743	8837	Gene	Gene	apoptosis|amod|START_ENTITY attenuates|dobj|apoptosis attenuates|nmod|regulation regulation|nmod|END_ENTITY	Interleukin-8 signaling attenuates TRAIL - and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate_cancer cells .
19956887	0	TRAIL	71,76	c-FLIP	104,110	TRAIL	c-FLIP	8743	8837	Gene	Gene	START_ENTITY|nmod|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	The sesquiterpene_lactone_eupatolide sensitizes breast_cancer cells to TRAIL through down-regulation of c-FLIP expression .
20706274	0	TRAIL	19,24	c-FLIP	120,126	TRAIL	c-FLIP	8743	8837	Gene	Gene	resistance|amod|START_ENTITY breaks|dobj|resistance breaks|nmod|suppression suppression|nmod|expression expression|amod|END_ENTITY	Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell_leukemia / lymphoma by translational suppression of c-FLIP expression .
21877938	0	TRAIL	19,24	c-FLIP	130,136	TRAIL	c-FLIP	8743	8837	Gene	Gene	pathway|amod|START_ENTITY restores|dobj|pathway restores|nmod|up-regulation up-regulation|nmod|DR5 DR5|nmod|END_ENTITY	Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP .
21914219	0	TRAIL	136,141	c-FLIP	35,41	TRAIL	c-FLIP	8743	8837	Gene	Gene	agent|appos|START_ENTITY stem|nmod|agent eliminates|ccomp|stem eliminates|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast_cancer stem cell activity in response to the anti-cancer agent , TRAIL .
21914854	0	TRAIL	64,69	c-FLIP	112,118	TRAIL	c-FLIP	8743	8837	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|xcomp|augment augment|advcl|facilitating facilitating|dobj|degradation degradation|amod|END_ENTITY	The NEDD8-activating enzyme inhibitor , MLN4924 , cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head_and_neck_cancer cells .
22086925	0	TRAIL	103,108	c-FLIP	161,167	TRAIL	c-FLIP	8743	8837	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|dep|START_ENTITY resistance|amod|tumor_necrosis_factor-related_apoptosis-inducing_ligand overcome|dobj|resistance overcome|nmod|down-regulation down-regulation|nmod|protein protein|amod|END_ENTITY	Wogonin and related natural flavones overcome tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression .
22086925	0	TRAIL	197,202	c-FLIP	161,167	TRAIL	c-FLIP	8743	8837	Gene	Gene	expression|amod|START_ENTITY down-regulation|nmod|expression down-regulation|nmod|protein protein|amod|END_ENTITY	Wogonin and related natural flavones overcome tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression .
22345097	0	TRAIL	77,82	c-FLIP	38,44	TRAIL	c-FLIP	8743	8837	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|degradation degradation|amod|END_ENTITY	The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition .
22551975	0	TRAIL	115,120	c-FLIP	95,101	TRAIL	c-FLIP	8743	8837	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Apoptosis induction by SAHA in cutaneous_T-cell_lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling .
23247197	0	TRAIL	126,131	c-FLIP	180,186	TRAIL	c-FLIP	8743	8837	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|DR5 DR5|nmod|END_ENTITY	Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP .
25824746	0	TRAIL	100,105	c-FLIP	14,20	TRAIL	c-FLIP	8743	8837	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of c-FLIP by RNAi Enhances Sensitivity of the Human Osteogenic_Sarcoma Cell Line U2OS to TRAIL - Induced Apoptosis .
26177636	0	TRAIL	148,153	c-FLIP	47,53	TRAIL	c-FLIP	8743	8837	Gene	Gene	agent|appos|START_ENTITY stem|nmod|agent eliminates|ccomp|stem eliminates|nsubj|END_ENTITY	Erratum to : Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast_cancer stem cell activity in response to the anti-cancer agent , TRAIL .
11384965	0	TRAIL	163,168	c-Fos	82,87	TRAIL	c-Fos	8743	2353	Gene	Gene	Fas|appos|START_ENTITY END_ENTITY|nmod|Fas	Fas-associated_death_domain_protein -LRB- FADD -RRB- and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- via a FLICE inhibitory protein -LRB- FLIP -RRB- - regulated pathway .
10548502	0	TRAIL	0,5	caspase-8	32,41	TRAIL	caspase-8	8743	841	Gene	Gene	causes|nsubj|START_ENTITY causes|nmod|END_ENTITY	TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells .
11032723	0	TRAIL	52,57	caspase-8	18,27	TRAIL	caspase-8	8743	841	Gene	Gene	JB6|nmod|START_ENTITY JB6|nsubj|Reconstitution Reconstitution|nmod|sensitizes sensitizes|amod|END_ENTITY	Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL .
11221844	0	TRAIL	87,92	caspase-8	95,104	TRAIL	caspase-8	8743	841	Gene	Gene	ligand|appos|START_ENTITY ligand|acl:relcl|required required|nsubjpass|END_ENTITY	Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- : caspase-8 is required for TRAIL-induced apoptosis .
11245427	0	TRAIL	71,76	caspase-8	145,154	TRAIL	caspase-8	8743	841	Gene	Gene	tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|START_ENTITY tumor_necrosis_factor-related_apoptosis-inducing_ligand|dep|apoptosis apoptosis|nmod|expression expression|amod|END_ENTITY	Resistance to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression .
11384965	0	TRAIL	163,168	caspase-8	47,56	TRAIL	caspase-8	8743	841	Gene	Gene	Fas|appos|START_ENTITY c-Fos|nmod|Fas up-regulation|nmod|c-Fos up-regulation|amod|END_ENTITY	Fas-associated_death_domain_protein -LRB- FADD -RRB- and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- via a FLICE inhibitory protein -LRB- FLIP -RRB- - regulated pathway .
12196516	0	TRAIL	0,5	caspase-8	57,66	TRAIL	caspase-8	22035(Tax:10090)	12370(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY signal|nsubj|receptor signal|xcomp|END_ENTITY	TRAIL receptor and CD95 signal to mitochondria via FADD , caspase-8 / 10 , Bid , and Bax but differentially regulate events downstream from truncated Bid .
16036110	0	TRAIL	61,66	caspase-8	27,36	TRAIL	caspase-8	8743	841	Gene	Gene	resistance|amod|START_ENTITY correlates|nmod|resistance correlates|nsubj|degradation degradation|nmod|protein protein|amod|END_ENTITY	Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon_cancer cell line .
16434995	0	TRAIL	0,5	caspase-8	43,52	TRAIL	caspase-8	8743	841	Gene	Gene	sensitisation|amod|START_ENTITY dependent|nsubj|sensitisation dependent|amod|END_ENTITY	TRAIL sensitisation by arsenic_trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt .
16750275	0	TRAIL	85,90	caspase-8	36,45	TRAIL	caspase-8	8743	841	Gene	Gene	death|amod|START_ENTITY sensitizes|nmod|death sensitizes|nsubj|transfection transfection|nmod|END_ENTITY	Adenovirus-mediated transfection of caspase-8 sensitizes hepatocellular_carcinoma to TRAIL - and chemotherapeutic agent-induced cell death .
19597472	0	TRAIL	101,106	caspase-8	147,156	TRAIL	caspase-8	8743	841	Gene	Gene	resistance|amod|START_ENTITY overcome|dobj|resistance overcome|advcl|silencing silencing|advcl|END_ENTITY	Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8 .
20442297	0	TRAIL	53,58	caspase-8	101,110	TRAIL	caspase-8	8743	841	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Bortezomib sensitizes human renal_cell_carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex .
21454681	0	TRAIL	67,72	caspase-8	141,150	TRAIL	caspase-8	8743	841	Gene	Gene	irrespective|amod|START_ENTITY irrespective|nmod|processing processing|nmod|END_ENTITY	Cellular FLICE-inhibitory protein -LRB- cFLIP -RRB- isoforms block CD95 - and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex .
21771726	0	TRAIL	128,133	caspase-8	78,87	TRAIL	caspase-8	8743	841	Gene	Gene	restores|nmod|START_ENTITY restores|dobj|expression expression|amod|END_ENTITY	Combined inhibition of DNA methyltransferase and histone_deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL .
22408249	0	TRAIL	152,157	caspase-8	33,42	TRAIL	caspase-8	8743	841	Gene	Gene	signaling|appos|START_ENTITY stimulation|nmod|signaling impair|nmod|stimulation impair|dobj|activation activation|amod|END_ENTITY	Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor_necrosis_factor-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- signaling .
23096115	0	TRAIL	84,89	caspase-8	43,52	TRAIL	caspase-8	8743	841	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-kB by TRAIL .
23678861	0	TRAIL	116,121	caspase-8	73,82	TRAIL	caspase-8	8743	841	Gene	Gene	receptosomes|amod|START_ENTITY trafficking|nmod|receptosomes trafficking|amod|END_ENTITY	Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes .
17914579	0	TRAIL	116,121	death_receptor_4	33,49	TRAIL	death receptor 4	8743	8797	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Glycosylation modulates TRAIL-R1 / death_receptor_4 protein : different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin .
25502339	0	TRAIL	64,69	death_receptor_5	82,98	TRAIL	death receptor 5	8743	8795	Gene	Gene	START_ENTITY|advcl|inducing inducing|dobj|END_ENTITY	Parthenolide enhances sensitivity of colorectal_cancer cells to TRAIL by inducing death_receptor_5 and promotes TRAIL-induced apoptosis .
14715264	0	TRAIL	33,38	histone_deacetylase	66,85	TRAIL	histone deacetylase	8743	9734	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone_deacetylase : role of Bcl-xL down-regulation .
16394281	0	TRAIL	76,81	osteoprotegerin	14,29	TRAIL	osteoprotegerin	8743	4982	Gene	Gene	ligand|appos|START_ENTITY inducing|dobj|ligand apoptosis|xcomp|inducing apoptosis|nsubj|Expression Expression|nmod|END_ENTITY	Expression of osteoprotegerin -LRB- OPG -RRB- , TNF related apoptosis inducing ligand -LRB- TRAIL -RRB- , and receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- in human breast_tumours .
18266968	0	TRAIL	8,13	osteoprotegerin	64,79	TRAIL	osteoprotegerin	8743	4982	Gene	Gene	impair|nsubj|START_ENTITY impair|dobj|activity activity|nmod|END_ENTITY	Soluble TRAIL does not impair the anti-osteoclastic activity of osteoprotegerin .
21251686	0	TRAIL	83,88	osteoprotegerin	158,173	TRAIL	osteoprotegerin	8743	4982	Gene	Gene	osteoprotegerin|appos|START_ENTITY elevated|nsubj|osteoprotegerin elevated|nmod|type type|acl:relcl|associated associated|nsubjpass|patients patients|nmod|END_ENTITY	Serum osteoprotegerin and tumor necrosis factor related apoptosis inducing-ligand -LRB- TRAIL -RRB- are elevated in type 2 diabetic patients with albuminuria and serum osteoprotegerin is independently associated with the severity of diabetic_nephropathy .
24280212	0	TRAIL	153,158	osteoprotegerin	121,136	TRAIL	osteoprotegerin	8743	4982	Gene	Gene	resistance|amod|START_ENTITY overcomes|dobj|resistance overcomes|nsubj|affinity affinity|nmod|necrosis necrosis|acl|factor-related factor-related|nmod|END_ENTITY	Decreased affinity of recombinant human tumor necrosis factor-related apoptosis-inducing ligand -LRB- rhTRAIL -RRB- D269H/E195R to osteoprotegerin -LRB- OPG -RRB- overcomes TRAIL resistance mediated by the bone microenvironment .
25520884	0	TRAIL	153,158	osteoprotegerin	96,111	TRAIL	osteoprotegerin	8743	4982	Gene	Gene	Effects|nmod|START_ENTITY Cells|nmod|Effects Cells|nsubj|Secretion Secretion|dep|END_ENTITY	Rab25 Small GTPase Mediates Secretion of Tumor Necrosis Factor Receptor Superfamily Member 11b -LRB- osteoprotegerin -RRB- Protecting Cancer Cells from Effects of TRAIL .
22415975	0	TRAIL	44,49	p300	30,34	TRAIL	p300	22035(Tax:10090)	328572(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	Sp1 , acetylated histone-3 and p300 regulate TRAIL transcription : mechanisms of PDGF-BB-mediated VSMC proliferation and migration .
25572524	0	TRAIL	101,106	p38	72,75	TRAIL	p38	8743	5594	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous_carcinoma FaDu cells .
19141642	0	TRAIL	100,105	p53	123,126	TRAIL	p53	8743	7157	Gene	Gene	independently|compound|START_ENTITY independently|nmod|END_ENTITY	IFN-alpha-induced apoptosis in hepatocellular_carcinoma involves promyelocytic_leukemia protein and TRAIL independently of p53 .
11309289	0	TRAIL	105,110	tumor_necrosis_factor-related_apoptosis-inducing_ligand	48,103	TRAIL	tumor necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Antitumor activity and bystander effects of the tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- gene .
12615731	0	TRAIL	151,156	tumor_necrosis_factor-related_apoptosis-inducing_ligand	94,149	TRAIL	tumor necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Induction of caspase_8 by interferon_gamma renders some neuroblastoma -LRB- NB -RRB- cells sensitive to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB .
15037583	0	TRAIL	86,91	tumor_necrosis_factor-related_apoptosis-inducing_ligand	29,84	TRAIL	tumor necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Uveal_melanoma expression of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptors and susceptibility to TRAIL-induced apoptosis .
16996498	0	TRAIL	90,95	tumor_necrosis_factor-related_apoptosis-inducing_ligand	33,88	TRAIL	tumor necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Generation of a novel proform of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- protein that can be reactivated by matrix metalloproteinases .
20542572	0	TRAIL	102,107	tumor_necrosis_factor-related_apoptosis-inducing_ligand	45,100	TRAIL	tumor necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The proteasome inhibitor bortezomib disrupts tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- expression and natural killer -LRB- NK -RRB- cell killing of TRAIL receptor-positive multiple_myeloma cells .
22027835	0	TRAIL	143,148	tumor_necrosis_factor-related_apoptosis-inducing_ligand	86,141	TRAIL	tumor necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	GDP-mannose-4 ,6 - dehydratase -LRB- GMDS -RRB- deficiency renders colon_cancer cells resistant to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptor - and CD95-mediated apoptosis by inhibiting complex II formation .
22408249	0	TRAIL	152,157	tumor_necrosis_factor-related_apoptosis_inducing_ligand	95,150	TRAIL	tumor necrosis factor-related apoptosis inducing ligand	8743	8743	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor_necrosis_factor-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- signaling .
19656161	0	TRAIL	75,80	tumour_necrosis_factor-related_apoptosis-inducing_ligand	17,73	TRAIL	tumour necrosis factor-related apoptosis-inducing ligand	8743	8743	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Emerging role of tumour_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- as a key regulator of inflammatory responses .
18978816	0	TRAIL	35,40	xIAP	97,101	TRAIL	xIAP	8743	331	Gene	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Sensitization of melanoma cells to TRAIL by UVB-induced and NF-kappaB-mediated downregulation of xIAP .
24761920	0	TRAIL-R1	20,28	DR4	15,18	TRAIL-R1	DR4	8797	8797	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of DR4 -LRB- TRAIL-R1 -RRB- polymorphisms with cancer risk in Caucasians : an updated meta-analysis .
17875785	0	TRAIL-R1	163,171	TRAIL	146,151	TRAIL-R1	TRAIL	8797	8743	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Bortezomib sensitizes non-Hodgkin 's _ lymphoma cells to apoptosis induced by antibodies to tumor necrosis factor related apoptosis-inducing ligand -LRB- TRAIL -RRB- receptors TRAIL-R1 and TRAIL-R2 .
12927928	0	TRAIL-R1	118,126	death_receptor_4	127,143	TRAIL-R1	death receptor 4	8797	8797	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Hepatitis_B_virus enhances tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- cytotoxicity by increasing TRAIL-R1 / death_receptor_4 expression .
17914579	0	TRAIL-R1	24,32	death_receptor_4	33,49	TRAIL-R1	death receptor 4	8797	8797	Gene	Gene	START_ENTITY|dep|protein protein|amod|END_ENTITY	Glycosylation modulates TRAIL-R1 / death_receptor_4 protein : different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin .
18093694	0	TRAIL-R2	91,99	DR5	100,103	TRAIL-R2	DR5	8795	8795	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2 / DR5 expression in the absence of caspase-8 .
11494138	0	TRAIL-R2	129,137	TRAIL	151,156	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	activation|nmod|START_ENTITY allows|dobj|activation allows|nmod|derivative derivative|amod|END_ENTITY	Differential activation of TRAIL-R1_and _ -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative .
11494138	0	TRAIL-R2	129,137	TRAIL	67,72	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	activation|nmod|START_ENTITY allows|dobj|activation allows|nsubj|activation activation|nmod|-2 -2|nmod|END_ENTITY	Differential activation of TRAIL-R1_and _ -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative .
17922877	0	TRAIL-R2	124,132	TRAIL	0,5	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	antibodies|compound|START_ENTITY facilitate|nsubj|antibodies apoptosis|advcl|facilitate signals|xcomp|apoptosis signals|nsubj|END_ENTITY	TRAIL signals to apoptosis in chronic_lymphocytic_leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2 .
17922877	0	TRAIL-R2	170,178	TRAIL	0,5	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	signalling|nmod|START_ENTITY facilitate|xcomp|signalling apoptosis|advcl|facilitate signals|xcomp|apoptosis signals|nsubj|END_ENTITY	TRAIL signals to apoptosis in chronic_lymphocytic_leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2 .
19079141	0	TRAIL-R2	111,119	TRAIL	75,80	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Inhibition of Aurora_B kinase sensitizes a subset of human glioma cells to TRAIL concomitant with induction of TRAIL-R2 .
24190693	0	TRAIL-R2	38,46	TRAIL	64,69	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Epigenetic and expression analysis of TRAIL-R2 and BCL2 : on the TRAIL to knowledge of apoptosis in ovarian_tumors .
25165876	0	TRAIL-R2	121,129	TRAIL	63,68	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	role|nmod|START_ENTITY functions|dep|role functions|appos|END_ENTITY	Compartmentalization of TNF-related apoptosis-inducing ligand -LRB- TRAIL -RRB- death receptor functions : emerging role of nuclear TRAIL-R2 .
9311998	0	TRAIL-R2	0,8	TRAIL	51,56	TRAIL-R2	TRAIL	8795	8743	Gene	Gene	START_ENTITY|dep|receptor receptor|nmod|END_ENTITY	TRAIL-R2 : a novel apoptosis-mediating receptor for TRAIL .
18093694	0	TRAIL-R2	91,99	caspase-8	133,142	TRAIL-R2	caspase-8	8795	841	Gene	Gene	expression|compound|START_ENTITY dependent|nmod|expression dependent|nmod|absence absence|nmod|END_ENTITY	TRAIL-induced survival and proliferation of SCLC cells is mediated by ERK and dependent on TRAIL-R2 / DR5 expression in the absence of caspase-8 .
11696376	0	TRAIL-R2	84,92	death_receptor_5	67,83	TRAIL-R2	death receptor 5	8795	8795	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Promoter structure and transcription initiation sites of the human death_receptor_5 / TRAIL-R2 gene .
15208660	0	TRAIL-R2	59,67	death_receptor_5	42,58	TRAIL-R2	death receptor 5	8795	8795	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|dep|END_ENTITY	Histone deacetylase inhibitors upregulate death_receptor_5 / TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant_tumor cells .
17645780	0	TRAIL-R2	48,56	death_receptor_5	31,47	TRAIL-R2	death receptor 5	8795	8795	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Lipoxygenase inhibitors induce death_receptor_5 / TRAIL-R2 expression and sensitize malignant_tumor cells to TRAIL-induced apoptosis .
21625476	0	TRAIL-R4	0,8	AKT	100,103	TRAIL-R4	AKT	8793	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical_carcinoma HeLa cells through AKT .
25211222	0	TRAM	34,38	RANTES	69,75	TRAM	RANTES	353376	6352	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|production production|compound|END_ENTITY	The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production .
25385819	0	TRAM	0,4	TLR2	21,25	TRAM	TLR2	353376	7097	Gene	Gene	Required|nsubjpass|START_ENTITY Required|nmod|Signaling Signaling|compound|END_ENTITY	TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction .
25825441	0	TRAM	91,95	TLR4	57,61	TRAM	TLR4	353376	7099	Gene	Gene	Pathway|nmod|START_ENTITY Pathway|compound|END_ENTITY	Phosphatase PTPN4 Preferentially Inhibits TRIF-Dependent TLR4 Pathway by Dephosphorylating TRAM .
24812060	0	TRAM	26,30	TRAF6	46,51	TRAM	TRAF6	353376	7189	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4 .
10433211	0	TRANCE	31,37	Parathyroid_hormone	0,19	TRANCE	Parathyroid hormone	21943(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Parathyroid_hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures : correlation with osteoclast-like cell formation .
11804028	0	TRANCE	83,89	TNFSF11	74,81	TRANCE	TNFSF11	117516(Tax:10116)	117516(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence that the rat osteopetrotic mutation toothless -LRB- tl -RRB- is not in the TNFSF11 -LRB- TRANCE , RANKL , ODF , OPGL -RRB- gene .
10433211	0	TRANCE	31,37	osteoprotegerin	51,66	TRANCE	osteoprotegerin	21943(Tax:10090)	18383(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Parathyroid_hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures : correlation with osteoclast-like cell formation .
11562486	0	TRANCE	30,36	osteoprotegerin	38,53	TRANCE	osteoprotegerin	8600	4982	Gene	Gene	cytokine|compound|START_ENTITY cytokine|compound|END_ENTITY	Multiple_myeloma disrupts the TRANCE / osteoprotegerin cytokine axis to trigger bone_destruction and promote tumor progression .
7615003	0	TRAP	18,22	CD40_ligand	24,35	TRAP	CD40 ligand	100187907	959	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	A soluble form of TRAP -LRB- CD40_ligand -RRB- is rapidly released after T cell activation .
14696961	0	TRAP	146,150	CSF-1	44,49	TRAP	CSF-1	25732(Tax:10116)	78965(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- on the development of osteoclasts and their expression of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- in toothless -LRB- tl-osteopetrotic -RRB- rats .
19801646	0	TRAP	184,188	interleukin_4	79,92	TRAP	interleukin 4	11433(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY ligand|dep|expression activator|nmod|ligand suppresses|dobj|activator suppresses|nsubj|regulation regulation|nmod|expression expression|nmod|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
19801646	0	TRAP	59,63	interleukin_4	79,92	TRAP	interleukin 4	11433(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
14597986	0	TRAP	124,128	protease-activated_receptor_1	14,43	TRAP	protease-activated receptor 1	100187907	2149	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of protease-activated_receptor_1 -LRB- PAR1 -RRB- on platelets and responsiveness to thrombin_receptor_activating_peptide -LRB- TRAP -RRB- during systemic inflammation in humans .
19801646	0	TRAP	59,63	tartrate-resistant_acid_phosphatase	22,57	TRAP	tartrate-resistant acid phosphatase	11433(Tax:10090)	11433(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
24587387	0	TRAP	71,75	thrombospondin-related_adhesive_protein	30,69	TRAP	thrombospondin-related adhesive protein	100187907	100187907	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Diversifying selection on the thrombospondin-related_adhesive_protein -LRB- TRAP -RRB- gene of Plasmodium_falciparum in Thailand .
23418473	0	TRAP-1-like_protein	11,30	TLP	32,35	TRAP-1-like protein	TLP	23339	23339	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of TRAP-1-like_protein -LRB- TLP -RRB- gene on collagen synthesis induced by TGF-b/Smad signaling in human dermal fibroblasts .
23284813	0	TRAP1	0,5	Drp1	60,64	TRAP1	Drp1	10131	10059	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression .
23747254	0	TRAP1	28,33	succinate_dehydrogenase	75,98	TRAP1	succinate dehydrogenase	10131	6390	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	The mitochondrial chaperone TRAP1 promotes neoplastic_growth by inhibiting succinate_dehydrogenase .
15329799	0	TRAR4	45,50	trace_amine_receptor_4	21,43	TRAR4	trace amine receptor 4	319100	319100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphisms in the trace_amine_receptor_4 -LRB- TRAR4 -RRB- gene on chromosome 6q23 .2 are associated with susceptibility to schizophrenia .
12671739	0	TRAV11	32,38	Valpha14	40,48	TRAV11	Valpha14	100126466(Tax:10090)	111622(Tax:10090)	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	Surprisingly minor influence of TRAV11 -LRB- Valpha14 -RRB- polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics .
22427937	0	TRAX	78,82	translin-associated_factor_X	48,76	TRAX	translin-associated factor X	7257	7257	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of nucleic acid binding sites on translin-associated_factor_X -LRB- TRAX -RRB- protein .
17576771	0	TRB2	0,4	AKT	84,87	TRB2	AKT	217410(Tax:10090)	11651(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|END_ENTITY	TRB2 , a mouse Tribbles ortholog , suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta .
16794074	0	TRB3	0,4	COP1	35,39	TRB3	COP1	228775(Tax:10090)	26374(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism .
17112672	0	TRB3	0,4	CtIP	20,24	TRB3	CtIP	57761	5932	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRB3 interacts with CtIP and is overexpressed in certain cancers .
19164449	0	TRB3	18,22	Insulin	0,7	TRB3	Insulin	57761	3630	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta .
21896644	0	TRB3	0,4	SMAD3	20,25	TRB3	SMAD3	57761	4088	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRB3 interacts with SMAD3 promoting tumor cell migration and invasion .
15973356	0	TRBP	0,4	Dicer	18,23	TRBP	Dicer	6896	23405	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|complex complex|compound|END_ENTITY	TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing .
16142218	0	TRBP	0,4	Dicer	77,82	TRBP	Dicer	6896	23405	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRBP , a regulator of cellular PKR and HIV-1 virus expression , interacts with Dicer and functions in RNA silencing .
25725290	0	TRBP	32,36	Early_growth_response_gene_1	0,28	TRBP	Early growth response gene 1	6895	1958	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Early_growth_response_gene_1 , a TRBP binding protein , is involved in miRNA activity of miR-125a-3p in human cells .
12475984	0	TRBP	29,33	PKR	172,175	TRBP	PKR	6895	5610	Gene	Gene	protein|appos|START_ENTITY stimulates|nsubj|protein stimulates|dobj|expression expression|nmod|ability ability|acl|inhibit inhibit|dobj|END_ENTITY	The TAR RNA-binding protein , TRBP , stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR .
16142218	0	TRBP	0,4	PKR	30,33	TRBP	PKR	6896	5610	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	TRBP , a regulator of cellular PKR and HIV-1 virus expression , interacts with Dicer and functions in RNA silencing .
16188979	0	TRBP	4,8	PKR	112,115	TRBP	PKR	6895	5610	Gene	Gene	levels|compound|START_ENTITY support|nsubj|levels support|advcl|enhancing enhancing|dobj|response response|compound|END_ENTITY	Low TRBP levels support an innate human_immunodeficiency_virus_type_1 resistance in astrocytes by enhancing the PKR antiviral response .
21937648	0	TRBP	38,42	PKR	150,153	TRBP	PKR	6896	5610	Gene	Gene	protein|appos|START_ENTITY promotes|nsubj|protein promotes|advcl|inhibiting inhibiting|dobj|activation activation|nmod|END_ENTITY	The cellular TAR RNA binding protein , TRBP , promotes HIV-1 replication primarily by inhibiting the activation of double-stranded RNA-dependent kinase PKR .
25843719	0	TRBP	39,43	PKR	20,23	TRBP	PKR	21357(Tax:10090)	19106(Tax:10090)	Gene	Gene	Complexes|nmod|START_ENTITY Complexes|compound|END_ENTITY	A Critical Role for PKR Complexes with TRBP in Immunometabolic Regulation and eIF2a Phosphorylation in Obesity .
9034343	0	TRBP	47,51	PKR	117,120	TRBP	PKR	6895	5610	Gene	Gene	potential|nmod|START_ENTITY kinase|nsubj|potential kinase|dobj|END_ENTITY	Oncogenic potential of TAR_RNA_binding_protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR .
21711701	0	TRBP	46,50	TAR-RNA_binding_protein	21,44	TRBP	TAR-RNA binding protein	6895	6895	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A proteomic study of TAR-RNA_binding_protein -LRB- TRBP -RRB- - associated factors .
17452327	0	TRBP	6,10	dicer	73,78	TRBP	dicer	6896	23405	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA .
9689122	0	TRC8	92,96	FHIT	60,64	TRC8	FHIT	11236	2272	Gene	Gene	gene|appos|START_ENTITY END_ENTITY|nmod|gene	The hereditary_renal_cell_carcinoma 3 ; 8 translocation fuses FHIT to a patched-related gene , TRC8 .
26383271	0	TRD	58,61	TRA	42,45	TRD	TRA	280945(Tax:9913)	6955	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Sheep -LRB- Ovis_aries -RRB- T_cell_receptor_alpha _ -LRB- TRA -RRB- _ and_delta -LRB- TRD -RRB- genes and genomic organization of the TRA/TRD locus .
23977412	0	TREK-1	102,108	Monocyte_Chemotactic_Protein-1	14,44	TREK-1	Monocyte Chemotactic Protein-1	3776	6347	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Monocyte_Chemotactic_Protein-1 secretion by the Two-Pore-Domain Potassium -LRB- K2P -RRB- channel TREK-1 in human alveolar epithelial cells .
18192027	0	TREM-1	4,10	DAP12	11,16	TREM-1	DAP12	54210	7305	Gene	Gene	START_ENTITY|dep|pathway pathway|nummod|END_ENTITY	The TREM-1 / DAP12 pathway .
17277102	0	TREM-1	57,63	Non-T_cell_activation_linker	0,28	TREM-1	Non-T cell activation linker	54210	7462	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Non-T_cell_activation_linker -LRB- NTAL -RRB- negatively regulates TREM-1 / DAP12-induced inflammatory cytokine production in myeloid cells .
23844229	0	TREM-1	12,18	TLR-4	6,11	TREM-1	TLR-4	54210	7099	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	TLR-2 / TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney_injury .
22642593	0	TREM-1	0,6	TNF-a	34,39	TREM-1	TNF-a	54210	7124	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	TREM-1 is a positive regulator of TNF-a and IL-8 production in U937 foam cells .
18321350	0	TREM-1	50,56	Triggering_receptor_expressed_on_myeloid_cells-1	0,48	TREM-1	Triggering receptor expressed on myeloid cells-1	54210	54210	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Triggering_receptor_expressed_on_myeloid_cells-1 -LRB- TREM-1 -RRB- expression on gastric epithelium : implication for a role of TREM-1 in Helicobacter_pylori_infection .
21549750	0	TREM-1	77,83	triggering_receptor_expressed_on_myeloid_cells-1	27,75	TREM-1	triggering receptor expressed on myeloid cells-1	54210	54210	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of triggering_receptor_expressed_on_myeloid_cells-1 -LRB- TREM-1 -RRB- on canine neutrophils .
19625651	0	TREM-2	145,151	NF-kappa_B	70,80	TREM-2	NF-kappa B	54209	4790	Gene	Gene	expression|compound|START_ENTITY inhibiting|dobj|expression signaling|advcl|inhibiting END_ENTITY|acl|signaling	IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa_B signaling during human osteoclast differentiation by inhibiting TREM-2 expression .
20484116	0	TREM2	0,5	PI3K	41,45	TREM2	PI3K	54209	5293	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	TREM2 - and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1 .
416208	0	TRF	32,35	Prolactin	0,9	TRF	Prolactin	7013	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to synthetic TRF in pregnant ewes .
5935575	0	TRF	50,53	thyrotropic_hormone-releasing_factor	12,48	TRF	thyrotropic hormone-releasing factor	7200	7200	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of thyrotropic_hormone-releasing_factor -LRB- TRF -RRB- in porcine hypothalamus .
4209106	0	TRF	46,49	thyrotropin-releasing_factor	16,44	TRF	thyrotropin-releasing factor	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of thyrotropin-releasing_factor -LRB- TRF -RRB- in the hypothalamus of the rat .
5003680	2	TRF	120,123	thyrotropin_releasing_factor	90,118	TRF	thyrotropin releasing factor	7200	7200	Gene	Gene	action|appos|START_ENTITY action|nmod|END_ENTITY	Biological action of synthetic thyrotropin_releasing_factor -LRB- TRF -RRB- in vivo and in vitro .
5841237	0	TRF	40,43	thyrotropin_releasing_factor	10,38	TRF	thyrotropin releasing factor	280825(Tax:9913)	280825(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin_releasing_factor -LRB- TRF -RRB- of ovine , bovine , porcine and human origin on thyrotropin release in vitro and in vivo .
22266654	0	TRF1	62,66	ATM	0,3	TRF1	ATM	7013	472	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	ATM regulates proteasome-dependent subnuclear localization of TRF1 , which is important for telomere maintenance .
18625707	0	TRF1	24,28	Plk1	0,4	TRF1	Plk1	7013	5347	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Plk1 phosphorylation of TRF1 is essential for its binding to telomeres .
20127252	0	TRF1	14,18	TERT	32,36	TRF1	TERT	7013	7015	Gene	Gene	KU70|compound|START_ENTITY KU70|appos|END_ENTITY	Expression of TRF1 , TRF2 , TIN2 , TERT , KU70 , and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric_cancer .
15133513	0	TRF1	44,48	TIN2	0,4	TRF1	TIN2	7013	26277	Gene	Gene	complex|compound|START_ENTITY modulator|nmod|complex modulator|nsubj|END_ENTITY	TIN2 is a tankyrase_1 PARP modulator in the TRF1 telomere length control complex .
15316005	0	TRF1	11,15	TIN2	0,4	TRF1	TIN2	7013	26277	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres .
20127252	0	TRF1	14,18	TIN2	26,30	TRF1	TIN2	7013	26277	Gene	Gene	KU70|compound|START_ENTITY KU70|appos|END_ENTITY	Expression of TRF1 , TRF2 , TIN2 , TERT , KU70 , and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric_cancer .
20127252	0	TRF1	14,18	TRF2	20,24	TRF1	TRF2	7013	7014	Gene	Gene	KU70|compound|START_ENTITY KU70|appos|END_ENTITY	Expression of TRF1 , TRF2 , TIN2 , TERT , KU70 , and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric_cancer .
23583392	0	TRF1	52,56	b-TrCP	18,24	TRF1	b-TrCP	7013	8945	Gene	Gene	ubiquitination|nmod|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	The F-box protein b-TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells .
15586405	0	TRF1	49,53	telomere_repeat_binding_factor_1	15,47	TRF1	telomere repeat binding factor 1	7013	7013	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	-LSB- Expression of telomere_repeat_binding_factor_1 -LRB- TRF1 -RRB- protein in kidney_cancer -RSB- .
19375317	0	TRF2	22,26	Chk2	36,40	TRF2	Chk2	7014	11200	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The shelterin protein TRF2 inhibits Chk2 activity at telomeres in the absence of DNA damage .
15172990	0	TRF2	35,39	DNA_polymerase_beta	0,19	TRF2	DNA polymerase beta	7014	5423	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DNA_polymerase_beta interacts with TRF2 and induces telomere_dysfunction in a murine mammary cell line .
12459787	0	TRF2	0,4	DREF	21,25	TRF2	DREF	31773(Tax:7227)	34328(Tax:7227)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila .
10984620	0	TRF2	31,35	Ku70	21,25	TRF2	Ku70	7014	2547	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human Ku70 with TRF2 .
19651898	0	TRF2	22,26	POT1	0,4	TRF2	POT1	7014	25913	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	POT1 association with TRF2 regulates telomere length .
15292264	0	TRF2	27,31	TIN2	0,4	TRF2	TIN2	7014	26277	Gene	Gene	functions|nmod|START_ENTITY mediates|dobj|functions mediates|nsubj|END_ENTITY	TIN2 mediates functions of TRF2 at human telomeres .
20127252	0	TRF2	20,24	TRF1	14,18	TRF2	TRF1	7014	7013	Gene	Gene	KU70|appos|START_ENTITY KU70|compound|END_ENTITY	Expression of TRF1 , TRF2 , TIN2 , TERT , KU70 , and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric_cancer .
2526744	0	TRG	54,57	T_cell_receptor_gamma	31,52	TRG	T cell receptor gamma	6965	6965	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Molecular mapping of the human T_cell_receptor_gamma -LRB- TRG -RRB- genes and linkage of the variable and constant regions .
3918278	0	TRH	0,3	GH	27,29	TRH	GH	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	TRH stimulation of in vivo GH release in the domestic fowl .
19289102	0	TRH	113,116	MKP-1	72,77	TRH	MKP-1	25569(Tax:10116)	114856(Tax:10116)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced prolactin gene expression .
1673063	0	TRH	48,51	Prolactin	0,9	TRH	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to submaximal stimulation by TRH in nonaffective psychoses .
3093910	0	TRH	30,33	Prolactin	0,9	TRH	Prolactin	7200	5617	Gene	Gene	response|xcomp|START_ENTITY response|nsubj|END_ENTITY	Prolactin and TSH response to TRH and metoclopramide before and after l-thyroxine therapy in subclinical_hypothyroidism .
3917409	0	TRH	53,56	Prolactin	0,9	TRH	Prolactin	7200	5617	Gene	Gene	response|appos|START_ENTITY response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with hypothalamic-pituitary_disease .
8874842	0	TRH	31,34	Prolactin	0,9	TRH	Prolactin	7200	5617	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin and TSH responses to TRH and to ECT in pre - and postmenopausal women with major_depression .
8471682	0	TRH	43,46	TRH	84,87	TRH	TRH	7200	7200	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Blunted TSH and unaltered PRL responses to TRH following repeated administration of TRH in neurologic patients : a replication of neuroendocrine features of major_depression .
8471682	0	TRH	84,87	TRH	43,46	TRH	TRH	7200	7200	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Blunted TSH and unaltered PRL responses to TRH following repeated administration of TRH in neurologic patients : a replication of neuroendocrine features of major_depression .
8294406	0	TRH	63,66	TRH_receptor	107,119	TRH	TRH receptor	7200	7201	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
3097590	0	TRH	31,34	Thyrotropin-releasing_hormone	0,29	TRH	Thyrotropin-releasing hormone	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- degradation in NIH : N mouse cerebral cortex and spinal cord .
6265032	0	TRH	31,34	Thyrotropin-releasing_hormone	0,29	TRH	Thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- content of rat striatum : modification by drugs and lesions .
8299576	0	TRH	31,34	Thyrotropin-releasing_hormone	0,29	TRH	Thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- gene expression in the anterior pituitary .
6273137	0	TRH	116,119	adrenocorticotropic_hormone	172,199	TRH	adrenocorticotropic hormone	7200	5443	Gene	Gene	correlation|appos|START_ENTITY correlation|nmod|END_ENTITY	Inverse correlation between urinary 17-hydroxycorticosteroid -LRB- 17-OHCS -RRB- excretion and thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced thyrotropin -LRB- TSH -RRB- response in disorders of adrenocorticotropic_hormone -LRB- ACTH -RRB- and adrenal secretion .
828709	0	TRH	55,58	growth_hormone	8,22	TRH	growth hormone	7200	2688	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Altered growth_hormone and prolactin responsiveness to TRH in the infant rat .
9430820	0	TRH	24,27	hTRH	29,33	TRH	hTRH	7200	7200	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of the human TRH -LRB- hTRH -RRB- gene by human thyroid_hormone receptor beta 1 -LRB- hTR beta 1 -RRB- mutants .
108096	0	TRH	29,32	prolactin	6,15	TRH	prolactin	7200	5617	Gene	Gene	Serum|nmod|START_ENTITY Serum|dobj|responses responses|compound|END_ENTITY	Serum prolactin responses to TRH in recurrent breast_cancer patients .
1332473	0	TRH	81,84	prolactin	58,67	TRH	prolactin	7200	5617	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|blockade blockade|nmod|responses responses|amod|verapamil verapamil|nmod|END_ENTITY	Effects of calcium channel blockade with verapamil on the prolactin responses to TRH , L-dopa , and bromocriptine .
1355520	0	TRH	164,167	prolactin	83,92	TRH	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|dobj|secretion secretion|compound|END_ENTITY	Intraventricular administration of thyrotrophin-releasing_hormone -LRB- TRH -RRB- suppresses prolactin secretion and synthesis : a possible involvement of dopamine release by TRH from rat hypothalamus .
1355520	0	TRH	67,70	prolactin	83,92	TRH	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	administration|appos|START_ENTITY suppresses|nsubj|administration suppresses|dobj|secretion secretion|compound|END_ENTITY	Intraventricular administration of thyrotrophin-releasing_hormone -LRB- TRH -RRB- suppresses prolactin secretion and synthesis : a possible involvement of dopamine release by TRH from rat hypothalamus .
19289102	0	TRH	113,116	prolactin	126,135	TRH	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	involvement|appos|START_ENTITY involvement|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Possible involvement of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced prolactin gene expression .
1947441	0	TRH	68,71	prolactin	15,24	TRH	prolactin	7200	5617	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|response response|compound|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- throughout the proliferative phases in the ovulatory and anovulatory menstrual cycle .
3119699	0	TRH	69,72	prolactin	10,19	TRH	prolactin	7200	5617	Gene	Gene	thyrotropin-releasing_hormone|dobj|START_ENTITY responsiveness|xcomp|thyrotropin-releasing_hormone responsiveness|nsubj|END_ENTITY	Subnormal prolactin responsiveness to thyrotropin-releasing_hormone -LRB- TRH -RRB- in women with primary_empty_sella_syndrome .
401551	0	TRH	62,65	prolactin	20,29	TRH	prolactin	7200	5617	Gene	Gene	response|xcomp|START_ENTITY response|nsubj|thyrotrophin thyrotrophin|amod|END_ENTITY	Serum thyrotrophin , prolactin and growth_hormone , response to TRH during oestrogen treatment .
404311	0	TRH	68,71	prolactin	15,24	TRH	prolactin	7200	5617	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|response response|compound|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- during the menstrual cycle of normal women .
6774631	1	TRH	245,248	prolactin	134,143	TRH	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	thyrotropin-releasing_hormone|appos|START_ENTITY Variation|nmod|thyrotropin-releasing_hormone Variation|nmod|content content|compound|END_ENTITY	Variation in prolactin content of individual cell colonies , and dynamics of stimulation with thyrotropin-releasing_hormone -LRB- TRH -RRB- .
7511776	0	TRH	0,3	prolactin	17,26	TRH	prolactin	7200	5617	Gene	Gene	START_ENTITY|dep|mediator mediator|nmod|END_ENTITY	TRH : mediator of prolactin in the prostate ?
3920581	0	TRH	39,42	thyroliberin	25,37	TRH	thyroliberin	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Developmental changes of thyroliberin -LRB- TRH -RRB- in the rat brain .
6774889	0	TRH	43,46	thyrotrophic-releasing_hormone	11,41	TRH	thyrotrophic-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotrophic-releasing_hormone -LRB- TRH -RRB- on thermoregulation in the rat .
6131565	0	TRH	46,49	thyrotrophin-releasing_hormone	14,44	TRH	thyrotrophin-releasing hormone	7200	7200	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of thyrotrophin-releasing_hormone -LRB- TRH -RRB- on pancreatic hormone secretion in normal subjects .
6404539	0	TRH	54,57	thyrotrophin-releasing_hormone	22,52	TRH	thyrotrophin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Stimulatory effect of thyrotrophin-releasing_hormone -LRB- TRH -RRB- on the release of luteinizing hormone -LRB- LH -RRB- from rat anterior pituitary cells in vitro .
8781630	0	TRH	59,62	thyrotrophin-releasing_hormone	27,57	TRH	thyrotrophin-releasing hormone	7200	7200	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of lithium and oral thyrotrophin-releasing_hormone -LRB- TRH -RRB- on serum thyrotrophin -LRB- TSH -RRB- and radioiodine uptake in patients with well differentiated thyroid_carcinoma .
3106117	0	TRH	49,52	thyrotropin-releasing_factor	19,47	TRH	thyrotropin-releasing factor	7200	7200	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Biphasic effect of thyrotropin-releasing_factor -LRB- TRH -RRB- on alpha-melanotropin secretion from frog intermediate lobe in vitro .
11738621	0	TRH	60,63	thyrotropin-releasing_hormone	29,58	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis and biology of new thyrotropin-releasing_hormone -LRB- TRH -RRB- analogues .
117895	0	TRH	67,70	thyrotropin-releasing_hormone	36,65	TRH	thyrotropin releasing hormone	7200	7200	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of thyrotropin-releasing_hormone -LRB- TRH -RRB- in skin of Rana pipiens .
12124766	0	TRH	47,50	thyrotropin-releasing_hormone	16,45	TRH	thyrotropin-releasing hormone	266721(Tax:7955)	266721(Tax:7955)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- immunoreactivity in the brain of the zebrafish -LRB- Danio_rerio -RRB- .
12697690	0	TRH	58,61	thyrotropin-releasing_hormone	27,56	TRH	thyrotropin-releasing hormone	397780(Tax:8355)	397780(Tax:8355)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Pharmacological studies of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors from Xenopus_laevis : is xTRHR3 a TRH_receptor ?
1324930	0	TRH	45,48	thyrotropin-releasing_hormone	14,43	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by thyrotropin-releasing_hormone -LRB- TRH -RRB- of TRH_receptor mRNA degradation in rat pituitary GH3 cells .
1359733	0	TRH	87,90	thyrotropin-releasing_hormone	56,85	TRH	thyrotropin-releasing hormone	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Adrenergic and non-adrenergic cardiovascular effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- in the anaesthetized rabbit .
1370611	0	TRH	44,47	thyrotropin-releasing_hormone	13,42	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Detection of thyrotropin-releasing_hormone -LRB- TRH -RRB- mRNA by the reverse transcription-polymerase chain reaction in the human normal and tumoral anterior pituitary .
1526263	0	TRH	55,58	thyrotropin-releasing_hormone	24,53	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Time-related effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the pituitary-thyroid_axis and extrathyroidal targets .
1651844	0	TRH	86,89	thyrotropin-releasing_hormone	55,84	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Epidermal_growth_factor decreases the concentration of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors and TRH responses in pituitary GH4C1 cells .
17474321	0	TRH	44,47	thyrotropin-releasing_hormone	13,42	TRH	thyrotropin-releasing hormone	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of thyrotropin-releasing_hormone -LRB- TRH -RRB- dialyzed into the hippocampus on memory processes in rabbit .
1803344	0	TRH	61,64	thyrotropin-releasing_hormone	30,59	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The cardiovascular effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- are attenuated by cimetidine in rats .
18382103	0	TRH	47,50	thyrotropin-releasing_hormone	16,45	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- immunoreactivity in the brain of urodele amphibians .
1850699	0	TRH	50,53	thyrotropin-releasing_hormone	19,48	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Down-regulation of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in spinal cord after transection as revealed by quantitative autoradiography .
18744	0	TRH	74,77	thyrotropin-releasing_hormone	43,72	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Lack of effect of chronically administered thyrotropin-releasing_hormone -LRB- TRH -RRB- on regional rat brain tyrosine_hydroxylase activity .
2108785	0	TRH	53,56	thyrotropin-releasing_hormone	22,51	TRH	thyrotropin-releasing hormone	100717613	100717613	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Excitatory effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- in hypoglossal motoneurons .
2112792	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on motor performance of hemiparetic_stroke patients .
2113675	0	TRH	100,103	thyrotropin-releasing_hormone	69,98	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	The effect of repeated administration of antidepressant drugs on the thyrotropin-releasing_hormone -LRB- TRH -RRB- content of rat brain structures .
2119425	0	TRH	42,45	thyrotropin-releasing_hormone	11,40	TRH	thyrotropin-releasing hormone	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on EEG topography -RSB- .
2124333	0	TRH	65,68	thyrotropin-releasing_hormone	34,63	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	The effect of fenfluramine on the thyrotropin-releasing_hormone -LRB- TRH -RRB- content in the rat brain structures and lumbar spinal cord .
2124486	0	TRH	73,76	thyrotropin-releasing_hormone	42,71	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Ca2 -LRB- + -RRB- - independent secretory mechanism of thyrotropin-releasing_hormone -LRB- TRH -RRB- involves protein_kinase_C in rat pituitary cells .
2156726	0	TRH	48,51	thyrotropin-releasing_hormone	17,46	TRH	thyrotropin-releasing hormone	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in brain thyrotropin-releasing_hormone -LRB- TRH -RRB- of seizure-prone El mice .
23000398	0	TRH	68,71	thyrotropin-releasing_hormone	37,66	TRH	thyrotropin-releasing hormone	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Family members CREB and CREM control thyrotropin-releasing_hormone -LRB- TRH -RRB- expression in the hypothalamus .
231172	0	TRH	55,58	thyrotropin-releasing_hormone	24,53	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	The direct influence of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the smooth muscle of rat duodenum .
24923830	0	TRH	54,57	thyrotropin-releasing_hormone	23,52	TRH	thyrotropin-releasing hormone	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Hypothalamic levels of thyrotropin-releasing_hormone -LRB- TRH -RRB- in male albino mice of different social status .
2501498	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the chemiluminescence -LRB- CL -RRB- activity of human mononuclear cells .
26216015	0	TRH	55,58	thyrotropin-releasing_hormone	24,53	TRH	thyrotropin-releasing hormone	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of CNS active thyrotropin-releasing_hormone -LRB- TRH -RRB- - like peptides : Biological evaluation and effect on cognitive_impairment induced by cerebral_ischemia in mice .
2834594	0	TRH	48,51	thyrotropin-releasing_hormone	17,46	TRH	thyrotropin-releasing hormone	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in brain thyrotropin-releasing_hormone -LRB- TRH -RRB- of El mice .
2864309	0	TRH	75,78	thyrotropin-releasing_hormone	44,73	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Correlative studies between the presence of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors and the in vitro stimulation of growth-hormone -LRB- GH -RRB- secretion in human GH-secreting adenomas .
2983260	0	TRH	64,67	thyrotropin-releasing_hormone	33,62	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Autoradiographic localization of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in human spinal cord .
2986203	0	TRH	48,51	thyrotropin-releasing_hormone	17,46	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Up-regulation of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in rat spinal cord after codepletion of serotonin and TRH .
3001843	0	TRH	46,49	thyrotropin-releasing_hormone	15,44	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of thyrotropin-releasing_hormone -LRB- TRH -RRB- neural system of the brain in pentylenetetrazol-induced seizures .
3085285	0	TRH	60,63	thyrotropin-releasing_hormone	29,58	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Acute and chronic effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on stabilogram in spinocerebellar_degenerations .
3098925	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Action|appos|START_ENTITY Action|nmod|END_ENTITY	Action of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the occurrence of fibrillation potentials and miniature end-plate potentials -LRB- MEPPs -RRB- .
3126225	0	TRH	47,50	thyrotropin-releasing_hormone	16,45	TRH	thyrotropin-releasing hormone	100717613	100717613	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- immunoreactivity in the thoracic spinal cord of guinea_pig .
3934717	0	TRH	76,79	thyrotropin-releasing_hormone	45,74	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Intraventricular 6-hydroxydopamine increases thyrotropin-releasing_hormone -LRB- TRH -RRB- content in regions of rat brain .
401667	0	TRH	59,62	thyrotropin-releasing_hormone	28,57	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Subcellular distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- in rat brain and hypothalamus .
4977749	0	TRH	46,49	thyrotropin-releasing_hormone	15,44	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Studies on the thyrotropin-releasing_hormone -LRB- TRH -RRB- activity in peripheral blood .
6104604	0	TRH	42,45	thyrotropin-releasing_hormone	11,40	TRH	thyrotropin-releasing hormone	100717613	100717613	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the isolated small intestine and taenia coli of the guinea_pig .
6322932	0	TRH	47,50	thyrotropin-releasing_hormone	16,45	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Localization of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in the septal nucleus of the rat brain .
6414881	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the synthesis and secretion of polysaccharides by the integument of gastropods .
6427443	0	TRH	73,76	thyrotropin-releasing_hormone	14,43	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Absorption of thyrotropin-releasing_hormone after oral administration of TRH tartrate monohydrate in the rat , dog and human .
6435101	0	TRH	51,54	thyrotropin-releasing_hormone	20,49	TRH	thyrotropin-releasing hormone	702455(Tax:9544)	702455(Tax:9544)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- in the rhesus_monkey spinal cord .
6778968	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on local cerebral glucose utilization , by the autoradiographic 2-deoxy -LSB- 14C -RSB- glucose method , in conscious and pentobarbitalized rats .
6801738	0	TRH	53,56	thyrotropin-releasing_hormone	22,51	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Seasonal variation in thyrotropin-releasing_hormone -LRB- TRH -RRB- content of different brain regions and the pineal in the mammalian hibernator , Citellus lateralis .
7805643	0	TRH	45,48	thyrotropin-releasing_hormone	14,43	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on limbic status_epilepticus in rats .
7884045	0	TRH	47,50	thyrotropin-releasing_hormone	16,45	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- - containing cells and fibers in the human hypothalamus .
805438	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	613414(Tax:9913)	613414(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on bovine plasma thyroxine levels at 18.5 and 35 C. Six mature nonlactating Holstein cows were subjected to a test procedure of a sham period -LRB- saline injection -RRB- of 10 days that prededed and followed each 14 day TRH treatment period at 18.5 and 35 degrees .
805836	0	TRH	42,45	thyrotropin-releasing_hormone	11,40	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the actions of pentobarbital and other centrally acting drugs .
806923	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	613414(Tax:9913)	613414(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on plasma glucocorticoids and thyroxine in cattle .
8282969	0	TRH	60,63	thyrotropin-releasing_hormone	29,58	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Neuroendocrine regulation of thyrotropin-releasing_hormone -LRB- TRH -RRB- in the tuberoinfundibular system .
8294406	0	TRH	63,66	thyrotropin-releasing_hormone	32,61	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
8301363	0	TRH	62,65	thyrotropin-releasing_hormone	31,60	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Early postnatal development of thyrotropin-releasing_hormone -LRB- TRH -RRB- expression , TRH receptor binding , and TRH responses in neurons of rat brainstem .
8956461	0	TRH	41,44	thyrotropin-releasing_hormone	10,39	TRH	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on cerebral blood flow in spinocerebellar_degeneration and cerebrovascular_disease .
8976533	0	TRH	67,70	thyrotropin-releasing_hormone	36,65	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Differential effects of intrathecal thyrotropin-releasing_hormone -LRB- TRH -RRB- on perineal reflexes in male rats .
9013814	0	TRH	47,50	thyrotropin-releasing_hormone	16,45	TRH	thyrotropin-releasing hormone	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in the brain of the ataxic mutant mouse , rolling mouse Nagoya .
9225129	0	TRH	59,62	thyrotropin-releasing_hormone	28,57	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Serotonin -LRB- 5-HT -RRB- stimulates thyrotropin-releasing_hormone -LRB- TRH -RRB- gene transcription in rat embryonic cardiomyocytes .
9421422	0	TRH	49,52	thyrotropin-releasing_hormone	18,47	TRH	thyrotropin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of rat thyrotropin-releasing_hormone -LRB- TRH -RRB- gene in TRH-producing tissues of transgenic_mice requires sequences located in exon 1 .
111817	0	TRH	48,51	thyrotropin_releasing_hormone	17,46	TRH	thyrotropin releasing hormone	7200	7200	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	-LSB- Distribution of thyrotropin_releasing_hormone -LRB- TRH -RRB- , alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- and somatostatin in the skin of the green frog -LRB- Rana esculenta -RRB- -RSB- .
2889280	0	TRH	42,45	thyrotropin_releasing_hormone	11,40	TRH	thyrotropin releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotropin_releasing_hormone -LRB- TRH -RRB- on glutamate-induced seizures in rats .
3126991	0	TRH	43,46	thyrotropin_releasing_hormone	12,41	TRH	thyrotropin releasing hormone	7200	7200	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	-LSB- Release of thyrotropin_releasing_hormone -LRB- TRH -RRB- from human prolactin-secreting pituitary_adenoma cells .
822448	0	TRH	44,47	thyrotropin_releasing_hormone	13,42	TRH	thyrotropin releasing hormone	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of thyrotropin_releasing_hormone -LRB- TRH -RRB- on drug-induced narcosis and hypothermia in rabbits .
8589718	0	TRH	53,56	thyrotropin_releasing_hormone	22,51	TRH	thyrotropin releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Ectopic expression of thyrotropin_releasing_hormone -LRB- TRH -RRB- receptors in liver modulates organ function to regulate blood glucose by TRH .
11064370	0	TRH-R2	56,62	thyrotropin-releasing_hormone_receptor_2	14,54	TRH-R2	thyrotropin-releasing hormone receptor 2	252859(Tax:10116)	252859(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of thyrotropin-releasing_hormone_receptor_2 -LRB- TRH-R2 -RRB- in the central nervous system of rats .
11566956	0	TRHR	40,44	Thyrotropin-releasing_hormone_receptor	0,38	TRHR	Thyrotropin-releasing hormone receptor	7201	7201	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Thyrotropin-releasing_hormone_receptor -LRB- TRHR -RRB- gene is associated with essential hypertension .
10371211	0	TRHR	67,71	thyrotropin-releasing_hormone_receptor	27,65	TRHR	thyrotropin-releasing hormone receptor	25570(Tax:10116)	25570(Tax:10116)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression analysis of the thyrotropin-releasing_hormone_receptor -LRB- TRHR -RRB- in the immune system using agonist anti-TRHR monoclonal antibodies .
8294406	0	TRH_receptor	107,119	TRH	63,66	TRH receptor	TRH	7201	7200	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
1324930	0	TRH_receptor	53,65	thyrotropin-releasing_hormone	14,43	TRH receptor	thyrotropin-releasing hormone	25570(Tax:10116)	25569(Tax:10116)	Gene	Gene	degradation|compound|START_ENTITY Regulation|nmod|degradation Regulation|nmod|END_ENTITY	Regulation by thyrotropin-releasing_hormone -LRB- TRH -RRB- of TRH_receptor mRNA degradation in rat pituitary GH3 cells .
8294406	0	TRH_receptor	107,119	thyrotropin-releasing_hormone	32,61	TRH receptor	thyrotropin-releasing hormone	7201	7200	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
24382668	0	TRIB1	77,82	MicroRNA-224	0,12	TRIB1	MicroRNA-224	10221	407009	Gene	Gene	downregulating|dobj|START_ENTITY inhibits|advcl|downregulating inhibits|nsubj|END_ENTITY	MicroRNA-224 inhibits progression of human prostate_cancer by downregulating TRIB1 .
26657055	0	TRIB1	33,38	Tribbles_Pseudokinase_1	8,31	TRIB1	Tribbles Pseudokinase 1	10221	10221	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Tribbles_Pseudokinase_1 -LRB- TRIB1 -RRB- in human hepatocyte metabolism .
25601649	0	TRIB3	0,5	Wnt5a	33,38	TRIB3	Wnt5a	228775(Tax:10090)	22418(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|nmod|END_ENTITY	TRIB3 mediates the expression of Wnt5a and activation of nuclear factor-kB in Porphyromonas endodontalis lipopolysaccharide-treated osteoblasts .
20675060	0	TRIB3	32,37	tribbles_homolog_3	12,30	TRIB3	tribbles homolog 3	106505984	106505984	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The porcine tribbles_homolog_3 -LRB- TRIB3 -RRB- gene : Identification of a missense mutation and association analysis with meat quality and production traits in Italian heavy pigs .
8001976	0	TRIC5	56,61	mTRiC-P5	41,49	TRIC5	mTRiC-P5	7203	12462(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human homologue of the mTRiC-P5 gene -LRB- TRIC5 -RRB- to band 1q23 by fluorescence in situ hybridization .
25636800	0	TRIF	67,71	IRF3	80,84	TRIF	IRF3	148022	3661	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|compound|END_ENTITY	Phosphorylation of innate immune adaptor proteins MAVS , STING , and TRIF induces IRF3 activation .
23479606	0	TRIF	86,90	WWP2	10,14	TRIF	WWP2	106759(Tax:10090)	66894(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation .
15345195	0	TRIM-8	69,75	Gerp	76,80	TRIM-8	Gerp	81603	81603	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization and cytokine-mediated inducibility of the human TRIM-8 / Gerp gene .
21338947	0	TRIM-9	0,6	UNC-6	24,29	TRIM-9	UNC-6	34453(Tax:7227)	180961(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	TRIM-9 functions in the UNC-6 / UNC-40 pathway to regulate ventral guidance .
23675467	0	TRIM11	0,6	IFNb	28,32	TRIM11	IFNb	81559	3456	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	TRIM11 negatively regulates IFNb production and antiviral activity by targeting TBK1 .
25088585	0	TRIM13	31,37	p65	47,50	TRIM13	p65	10206	5970	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Participation of the E3-ligase TRIM13 in NF-kB p65 activation and NFAT-dependent activation of c-Rel upon T-cell receptor engagement .
22479513	0	TRIM21	52,58	IRF3	97,101	TRIM21	IRF3	6737	3661	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity .
22509910	0	TRIM22	20,26	eIF4E	99,104	TRIM22	eIF4E	10346	1977	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G .
19909775	0	TRIM24	0,6	androgen_receptor	47,64	TRIM24	androgen receptor	8805	367	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	TRIM24 mediates ligand-dependent activation of androgen_receptor and is repressed by a bromodomain-containing protein , BRD7 , in prostate_cancer cells .
19454348	0	TRIM25	51,57	NS1	18,21	TRIM25	NS1	7706	10625	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Influenza_A_virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I .
25763818	0	TRIM26	0,6	IRF3	129,133	TRIM26	IRF3	22670(Tax:10090)	54131(Tax:10090)	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	TRIM26 Negatively Regulates Interferon-b Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3 .
22829933	0	TRIM27	0,6	NOD2	28,32	TRIM27	NOD2	5987	64127	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation .
26358190	0	TRIM27	106,112	TBK1	64,68	TRIM27	TBK1	5987	29110	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27 .
18287239	0	TRIM28	91,97	HP1	76,79	TRIM28	HP1	21849(Tax:10090)	12419(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Primer binding site-dependent restriction_of_murine_leukemia virus requires HP1 binding by TRIM28 .
22110054	0	TRIM28	0,6	ZFP568	52,58	TRIM28	ZFP568	21849(Tax:10090)	243905(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues .
20368352	0	TRIM29	10,16	ATDC	4,8	TRIM29	ATDC	23650	23650	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The ATDC -LRB- TRIM29 -RRB- protein binds p53 and antagonizes p53-mediated functions .
20947501	0	TRIM29	67,73	ATDC	61,65	TRIM29	ATDC	23650	23650	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Histone_deacetylase_9 -LRB- HDAC9 -RRB- regulates the functions of the ATDC -LRB- TRIM29 -RRB- protein .
21463657	0	TRIM29	0,6	p53	28,31	TRIM29	p53	23650	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TRIM29 negatively regulates p53 via inhibition of Tip60 .
19665990	0	TRIM31	0,6	p52	22,25	TRIM31	p52	11074	4791	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRIM31 interacts with p52 -LRB- Shc -RRB- and inhibits Src-induced anchorage-independent growth .
21628460	0	TRIM32	0,6	TNFa	58,62	TRIM32	TNFa	22954	7124	Gene	Gene	cells|nummod|START_ENTITY cells|appos|END_ENTITY	TRIM32 protein sensitizes cells to tumor_necrosis_factor -LRB- TNFa -RRB- - induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- .
21798009	0	TRIM32	55,61	malin	35,40	TRIM32	malin	22954	378884	Gene	Gene	related|xcomp|START_ENTITY related|nsubjpass|END_ENTITY	Lafora_disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level .
25146927	0	TRIM32	20,26	p53	65,68	TRIM32	p53	22954	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis .
25381221	0	TRIM33	16,22	miR-629	0,7	TRIM33	miR-629	51592	693214	Gene	Gene	START_ENTITY|nsubj|Targets Targets|amod|END_ENTITY	miR-629 Targets TRIM33 to Promote TGFb/Smad Signaling and Metastatic Phenotypes in ccRCC .
25907537	0	TRIM35	0,6	IRF7	94,98	TRIM35	IRF7	23087	3665	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	TRIM35 negatively regulates TLR7 - and TLR9-mediated type I interferon production by targeting IRF7 .
25907537	0	TRIM35	0,6	TLR7	28,32	TRIM35	TLR7	23087	51284	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	TRIM35 negatively regulates TLR7 - and TLR9-mediated type I interferon production by targeting IRF7 .
25263439	0	TRIM35	0,6	pyruvate_kinase_isoform_M2	22,48	TRIM35	pyruvate kinase isoform M2	23087	5315	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	TRIM35 Interacts with pyruvate_kinase_isoform_M2 to suppress the Warburg effect and tumorigenicity in hepatocellular_carcinoma .
19232519	0	TRIM36	0,6	CENP-H	46,52	TRIM36	CENP-H	55521	64946	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression .
23056470	0	TRIM38	0,6	IFN-b	42,47	TRIM38	IFN-b	10475	3456	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TRIM38 negatively regulates TLR3-mediated IFN-b signaling by targeting TRIF for degradation .
23213251	0	TRIM39	0,6	p21	81,84	TRIM39	p21	56658	644914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21 .
24681954	0	TRIM45	22,28	RACK1	53,58	TRIM45	RACK1	80263	10399	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway .
22588174	0	TRIM59	0,6	ECSIT	22,27	TRIM59	ECSIT	286827	51295	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRIM59 interacts with ECSIT and negatively regulates NF-kB and IRF-3 / 7-mediated signal pathways .
22328504	0	TRIM6	0,5	Myc	21,24	TRIM6	Myc	94088(Tax:10090)	17869(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells .
27012201	0	TRIM65	0,6	p53	28,31	TRIM65	p53	201292	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TRIM65 negatively regulates p53 through ubiquitination .
24999993	0	TRIM68	0,6	IFN-b	28,33	TRIM68	IFN-b	55128	3456	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	TRIM68 negatively regulates IFN-b production by degrading TRK fused gene , a novel driver of IFN-b downstream of anti-viral detection systems .
24999993	0	TRIM68	0,6	IFN-b	92,97	TRIM68	IFN-b	55128	3456	Gene	Gene	regulates|nsubj|START_ENTITY fused|dep|regulates fused|nsubj|gene gene|appos|driver driver|nmod|downstream downstream|compound|END_ENTITY	TRIM68 negatively regulates IFN-b production by degrading TRK fused gene , a novel driver of IFN-b downstream of anti-viral detection systems .
25664835	0	TRIM68	12,18	IFN-b	104,109	TRIM68	IFN-b	55128	3456	Gene	Gene	Production|compound|START_ENTITY Production|nmod|TRK_Fused_Gene TRK_Fused_Gene|appos|Driver Driver|nmod|Downstream Downstream|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	TRIM68	12,18	IFN-b	40,45	TRIM68	IFN-b	55128	3456	Gene	Gene	Production|compound|START_ENTITY Production|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	TRIM68	12,18	TRK_Fused_Gene	70,84	TRIM68	TRK Fused Gene	55128	10342	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
21689689	0	TRIM8	0,5	Nanog	16,21	TRIM8	Nanog	81603	79923	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TRIM8 regulates Nanog via Hsp90b-mediated nuclear translocation of STAT3 in embryonic stem cells .
20516148	0	TRIM8	0,5	STAT3	16,21	TRIM8	STAT3	93679(Tax:10090)	20848(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	TRIM8 modulates STAT3 activity through negative regulation of PIAS3 .
22262183	0	TRIM8	0,5	p53	16,19	TRIM8	p53	81603	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	TRIM8 modulates p53 activity to dictate cell cycle arrest .
17927961	0	TRIP	89,93	TRAF-interacting_protein	63,87	TRIP	TRAF-interacting protein	22036(Tax:10090)	22036(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Early embryonic_lethality caused by targeted disruption of the TRAF-interacting_protein -LRB- TRIP -RRB- gene .
9599024	0	TRIP-1	96,102	TGFbeta-receptor_interacting_protein-1	56,94	TRIP-1	TGFbeta-receptor interacting protein-1	8668	8668	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure and chromosomal location of the human TGFbeta-receptor_interacting_protein-1 -LRB- TRIP-1 -RRB- gene to 1p34 .1 .
18627766	0	TRIP12	0,6	APP-BP1	46,53	TRIP12	APP-BP1	9320	8883	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	TRIP12 functions as an E3 ubiquitin ligase of APP-BP1 .
23339869	0	TRIP6	0,5	KIP1	20,24	TRIP6	KIP1	7205	1027	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TRIP6 regulates p27 KIP1 to promote tumorigenesis .
14970849	0	TRITHORAX	38,47	MLL1	6,10	TRITHORAX	MLL1	41737(Tax:7227)	4297	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	ALL-1 / MLL1 , a homologue of Drosophila TRITHORAX , modifies chromatin and is directly involved in infant acute_leukaemia .
11553687	0	TRK	55,58	neurotrophin	59,71	TRK	neurotrophin	4914	627	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	The non-peptidyl fungal metabolite L-783 ,281 activates TRK neurotrophin receptors .
7972209	0	TRK-A	61,66	nerve_growth_factor_receptor	31,59	TRK-A	nerve growth factor receptor	4914	4804	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and function of the nerve_growth_factor_receptor -LRB- TRK-A -RRB- in human neuroblastoma cell lines .
23810392	0	TRK-fused_gene	61,75	TFG	77,80	TRK-fused gene	TFG	10342	10342	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused_gene -LRB- TFG -RRB- protein .
15731354	0	TRKA	37,41	CD34	67,71	TRKA	CD34	4914	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34 + cells , allowing nerve_growth_factor-induced expansion .
10330344	0	TRKA	73,77	NTRK1	79,84	TRKA	NTRK1	4914	4914	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Congenital_insensitivity_to_pain_with_anhidrosis : novel mutations in the TRKA -LRB- NTRK1 -RRB- gene encoding a high-affinity receptor for nerve_growth_factor .
10982191	0	TRKA	42,46	NTRK1	48,53	TRKA	NTRK1	4914	4914	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation and polymorphism analysis of the TRKA -LRB- NTRK1 -RRB- gene encoding a high-affinity receptor for nerve growth factor in congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- families .
11071380	0	TRKA	94,98	NTRK1	100,105	TRKA	NTRK1	4914	4914	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with congenital_insensitivity_to_pain_with_anhidrosis .
11668614	0	TRKA	80,84	NTRK1	86,91	TRKA	NTRK1	4914	4914	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Congenital_insensitivity_to_pain_with_anhidrosis -LRB- CIPA -RRB- : novel mutations of the TRKA -LRB- NTRK1 -RRB- gene , a putative uniparental_disomy , and a linkage of the mutant TRKA and PKLR genes in a family with CIPA and pyruvate_kinase_deficiency .
11748840	0	TRKA	107,111	NTRK1	113,118	TRKA	NTRK1	4914	4914	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular basis of congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : mutations and polymorphisms in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve_growth_factor .
12102460	1	TRKA	183,187	NTRK1	188,193	TRKA	NTRK1	4914	4914	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Clinical , biological and molecular aspects of mutations in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve growth factor .
12210794	0	TRKA	19,23	NTRK1	25,30	TRKA	NTRK1	4914	4914	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No mutation in the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with hereditary_sensory_and_autonomic_neuropathy_type_V .
10330344	0	TRKA	73,77	nerve_growth_factor	129,148	TRKA	nerve growth factor	4914	4803	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|receptor receptor|nmod|END_ENTITY	Congenital_insensitivity_to_pain_with_anhidrosis : novel mutations in the TRKA -LRB- NTRK1 -RRB- gene encoding a high-affinity receptor for nerve_growth_factor .
11159935	0	TRKA	67,71	nerve_growth_factor	158,177	TRKA	nerve growth factor	4914	4803	Gene	Gene	effect|nmod|START_ENTITY Congenital_insensitivity|dep|effect missense|nsubj|Congenital_insensitivity missense|nmod|autophosphorylation autophosphorylation|nmod|receptor_tyrosine_kinase receptor_tyrosine_kinase|nmod|END_ENTITY	Congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : effect of TRKA -LRB- NTRK1 -RRB- missense mutations on autophosphorylation of the receptor_tyrosine_kinase for nerve_growth_factor .
11748840	0	TRKA	107,111	nerve_growth_factor	167,186	TRKA	nerve growth factor	4914	4803	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene mutations|acl|encoding encoding|dobj|receptor_tyrosine_kinase receptor_tyrosine_kinase|nmod|END_ENTITY	Molecular basis of congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : mutations and polymorphisms in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve_growth_factor .
11071380	0	TRKA	94,98	receptor_tyrosine_kinase	123,147	TRKA	receptor tyrosine kinase	4914	5979	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with congenital_insensitivity_to_pain_with_anhidrosis .
11159935	0	TRKA	67,71	receptor_tyrosine_kinase	129,153	TRKA	receptor tyrosine kinase	4914	5979	Gene	Gene	effect|nmod|START_ENTITY Congenital_insensitivity|dep|effect missense|nsubj|Congenital_insensitivity missense|nmod|autophosphorylation autophosphorylation|nmod|END_ENTITY	Congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : effect of TRKA -LRB- NTRK1 -RRB- missense mutations on autophosphorylation of the receptor_tyrosine_kinase for nerve_growth_factor .
11748840	0	TRKA	107,111	receptor_tyrosine_kinase	138,162	TRKA	receptor tyrosine kinase	4914	5979	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene mutations|acl|encoding encoding|dobj|END_ENTITY	Molecular basis of congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : mutations and polymorphisms in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve_growth_factor .
12102460	1	TRKA	183,187	receptor_tyrosine_kinase	213,237	TRKA	receptor tyrosine kinase	4914	5979	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene aspects|nmod|mutations aspects|acl|encoding encoding|dobj|END_ENTITY	Clinical , biological and molecular aspects of mutations in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve growth factor .
12210794	0	TRKA	19,23	receptor_tyrosine_kinase	48,72	TRKA	receptor tyrosine kinase	4914	5979	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	No mutation in the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with hereditary_sensory_and_autonomic_neuropathy_type_V .
23867621	0	TRKB	31,35	MMP9	39,43	TRKB	MMP9	4915	4318	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain .
12202482	0	TRKB	14,18	TRKB	89,93	TRKB	TRKB	4915	4915	Gene	Gene	Regulation|nmod|START_ENTITY surface|nsubj|Regulation surface|nmod|isoforms isoforms|compound|END_ENTITY	Regulation of TRKB surface expression by brain-derived_neurotrophic_factor and truncated TRKB isoforms .
12202482	0	TRKB	89,93	TRKB	14,18	TRKB	TRKB	4915	4915	Gene	Gene	isoforms|compound|START_ENTITY surface|nmod|isoforms surface|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of TRKB surface expression by brain-derived_neurotrophic_factor and truncated TRKB isoforms .
12202482	0	TRKB	14,18	brain-derived_neurotrophic_factor	41,74	TRKB	brain-derived neurotrophic factor	4915	627	Gene	Gene	Regulation|nmod|START_ENTITY surface|nsubj|Regulation surface|nmod|isoforms isoforms|compound|END_ENTITY	Regulation of TRKB surface expression by brain-derived_neurotrophic_factor and truncated TRKB isoforms .
12202482	0	TRKB	89,93	brain-derived_neurotrophic_factor	41,74	TRKB	brain-derived neurotrophic factor	4915	627	Gene	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Regulation of TRKB surface expression by brain-derived_neurotrophic_factor and truncated TRKB isoforms .
22265740	0	TRKC	30,34	SOX2	38,42	TRKC	SOX2	4916	6657	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells .
11310631	0	TRK_A	8,13	NTRK1	15,20	TRK A	NTRK1	4914	4914	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A novel TRK_A -LRB- NTRK1 -RRB- mutation associated with hereditary_sensory_and_autonomic_neuropathy_type_V .
25664835	0	TRK_Fused_Gene	70,84	IFN-b	104,109	TRK Fused Gene	IFN-b	10342	3456	Gene	Gene	START_ENTITY|appos|Driver Driver|nmod|Downstream Downstream|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	TRK_Fused_Gene	70,84	IFN-b	40,45	TRK Fused Gene	IFN-b	10342	3456	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
25664835	0	TRK_Fused_Gene	70,84	TRIM68	12,18	TRK Fused Gene	TRIM68	10342	55128	Gene	Gene	Production|nmod|START_ENTITY Production|compound|END_ENTITY	Correction : TRIM68 Negatively Regulates IFN-b Production by Degrading TRK_Fused_Gene , a Novel Driver of IFN-b Downstream of Anti-Viral Detection Systems .
9710594	0	TRP-1	86,91	Tbx2	39,43	TRP-1	Tbx2	7306	6909	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter .
7855068	0	TRP1	26,30	DHICA_oxidase	0,13	TRP1	DHICA oxidase	22178(Tax:10090)	22178(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	DHICA_oxidase activity of TRP1 and interactions with other melanogenic enzymes .
7958943	0	TRP1	41,45	trp1	84,88	TRP1	trp1	851570(Tax:4932)	851570(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Characterization of the Candida_albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation .
8048919	0	TRP2	47,51	dopachrome_tautomerase	56,78	TRP2	dopachrome tautomerase	104042(Tax:10090)	13190(Tax:10090)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Functional analysis of the slaty gene product -LRB- TRP2 -RRB- as dopachrome_tautomerase and the effect of a point mutation on its catalytic function .
24475287	0	TRP2	18,22	p53	0,3	TRP2	p53	1638	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	p53 regulation by TRP2 is not pervasive in melanoma .
10897046	0	TRP2	102,106	tyrosinase-related_protein_2	72,100	TRP2	tyrosinase-related protein 2	1638	1638	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	Identification of a new HLA-A -LRB- * -RRB- 0201-restricted T-cell epitope from the tyrosinase-related_protein_2 -LRB- TRP2 -RRB- melanoma antigen .
11042129	0	TRP4	68,72	transient_receptor_potential_4	36,66	TRP4	transient receptor potential 4	7223	7223	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and expression of the human transient_receptor_potential_4 -LRB- TRP4 -RRB- gene : localization and functional expression of human TRP4 and TRP3 .
6282714	0	TRP5	74,78	IS2	52,55	TRP5	IS2	852858(Tax:4932)	8381885(Tax:562)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	DNA sequences flanking an E. _ coli insertion element IS2 in a cloned yeast TRP5 gene .
24357536	0	TRPA1	47,52	CCK	29,32	TRPA1	CCK	8989	885	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Unsaturated aldehydes induce CCK secretion via TRPA1 in STC-1 cells .
16500080	0	TRPA1	0,5	CYLD	67,71	TRPA1	CYLD	8989	1540	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD .
21890837	0	TRPA1	56,61	STC-1	106,111	TRPA1	STC-1	8989	6781	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Green tea polyphenol epigallocatechin_gallate activates TRPA1 in an intestinal enteroendocrine cell line , STC-1 .
25068659	0	TRPA1	0,5	TGF-b	22,27	TRPA1	TGF-b	277328(Tax:10090)	21803(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|signaling signaling|compound|END_ENTITY	TRPA1 is required for TGF-b signaling and its loss_blocks inflammatory fibrosis in mouse corneal_stroma .
17517374	0	TRPA1	10,15	TRPM8	17,22	TRPA1	TRPM8	312896(Tax:10116)	171384(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased TRPA1 , TRPM8 , and TRPV2 expression in dorsal root ganglia by nerve_injury .
18384850	0	TRPA1	41,46	TRPM8	58,63	TRPA1	TRPM8	8989	79054	Gene	Gene	cold|dep|START_ENTITY receptors|amod|cold receptors|appos|END_ENTITY	Differential expression profile of cold -LRB- TRPA1 -RRB- and cool -LRB- TRPM8 -RRB- receptors in human urogenital organs .
23192000	0	TRPA1	69,74	TRPM8	15,20	TRPA1	TRPM8	8989	79054	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|1,8-cineole 1,8-cineole|appos|agonist agonist|compound|END_ENTITY	1,8-cineole , a TRPM8 agonist , is a novel natural antagonist of human TRPA1 .
24975826	0	TRPA1	102,107	TRPM8	6,11	TRPA1	TRPM8	8989	79054	Gene	Gene	R797T|compound|START_ENTITY agonists|appos|R797T sensitivity|nmod|agonists variant|nmod|sensitivity END_ENTITY|nmod|variant	Human TRPM8 and TRPA1 pain channels , including a gene variant with increased sensitivity to agonists -LRB- TRPA1 R797T -RRB- , exhibit differential regulation by SRC-tyrosine kinase inhibitor .
26171233	0	TRPA1	42,47	TRPV1	18,23	TRPA1	TRPV1	8989	7442	Gene	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Propofol restores TRPV1 sensitivity via a TRPA1 - , nitric_oxide_synthase-dependent activation of PKC .
18468780	0	TRPA1	33,38	Transient_receptor_potential_A1	0,31	TRPA1	Transient receptor potential A1	8989	8989	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Transient_receptor_potential_A1 -LRB- TRPA1 -RRB- activity in the human urethra -- evidence for a functional role for TRPA1 in the outflow region .
26746673	0	TRPA1	40,45	Transient_receptor_potential_ankyrin_1	0,38	TRPA1	Transient receptor potential ankyrin 1	277328(Tax:10090)	277328(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- receptor is involved in chronic arthritis : in vivo study using TRPA1-deficient mice .
21460831	0	TRPA1	0,5	itch	93,97	TRPA1	itch	277328(Tax:10090)	16396(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	TRPA1 is required for histamine-independent , Mas-related G protein-coupled receptor-mediated itch .
20056530	0	TRPA1	56,61	transient_receptor_potential_A1	23,54	TRPA1	transient receptor potential A1	8989	8989	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	The involvement of the transient_receptor_potential_A1 -LRB- TRPA1 -RRB- in the maintenance of mechanical and cold_hyperalgesia in persistent inflammation .
24884675	0	TRPA1	146,151	transient_receptor_potential_A1	113,144	TRPA1	transient receptor potential A1	8989	8989	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery , optimization , and biological evaluation of 5 - -LRB- 2 - -LRB- trifluoromethyl -RRB- phenyl -RRB- indazoles as a novel class of transient_receptor_potential_A1 -LRB- TRPA1 -RRB- antagonists .
23541125	0	TRPA1	54,59	transient_receptor_potential_ankyrin-1	14,52	TRPA1	transient receptor potential ankyrin-1	8989	8989	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of transient_receptor_potential_ankyrin-1 -LRB- TRPA1 -RRB- in lung cells by wood_smoke particulate material .
18086308	0	TRPA1	112,117	transient_receptor_potential_ankyrin_1	72,110	TRPA1	transient receptor potential ankyrin 1	8989	8989	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Species-specific pharmacology of Trichloro -LRB- sulfanyl -RRB- ethyl_benzamides as transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- antagonists .
22641084	0	TRPA1	91,96	transient_receptor_potential_ankyrin_1	51,89	TRPA1	transient receptor potential ankyrin 1	277328(Tax:10090)	277328(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	H -LRB- 2 -RRB- S functions as a nociceptive messenger through transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- activation .
22721614	0	TRPA1	52,57	transient_receptor_potential_ankyrin_1	12,50	TRPA1	transient receptor potential ankyrin 1	312896(Tax:10116)	312896(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The role of transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation .
25897313	0	TRPA1	46,51	transient_receptor_potential_cation_channel	53,96	TRPA1	transient receptor potential cation channel	8989	8989	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	The role of flavor and fragrance chemicals in TRPA1 -LRB- transient_receptor_potential_cation_channel , member A1 -RRB- activity associated with allergies .
23034388	0	TRPC1	0,5	STIM1	30,35	TRPC1	STIM1	22063(Tax:10090)	20866(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	TRPC1 and Orai1 interact with STIM1 and mediate capacitative Ca -LRB- 2 + -RRB- entry caused by acute hypoxia in mouse pulmonary arterial smooth muscle cells .
21996795	0	TRPC1	30,35	TRPC3	41,46	TRPC1	TRPC3	7220	7222	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and association of TRPC1 with TRPC3 during skeletal myogenesis .
25971967	0	TRPC1	42,47	Transient_receptor_potential_canonical_1	0,40	TRPC1	Transient receptor potential canonical 1	7220	7220	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transient_receptor_potential_canonical_1 -LRB- TRPC1 -RRB- channels as regulators of sphingolipid - and VEGF receptor expression : implications for thyroid_cancer cell migration and proliferation .
12855710	0	TRPC1	68,73	Tumor_necrosis_factor-alpha	0,27	TRPC1	Tumor necrosis factor-alpha	7220	7124	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces nuclear_factor-kappaB-dependent TRPC1 expression in endothelial cells .
18544631	0	TRPC1	0,5	caveolin-3	15,25	TRPC1	caveolin-3	22063(Tax:10090)	12391(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne_muscular_dystrophy .
16899508	0	TRPC1	59,64	transient_receptor_potential_canonical_1	17,57	TRPC1	transient receptor potential canonical 1	7220	7220	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of transient_receptor_potential_canonical_1 -LRB- TRPC1 -RRB- following sarco -LRB- endo -RRB- plasmic_reticulum_Ca2 + _ ATPase 2 gene silencing promotes cell survival : a potential role for TRPC1 in Darier 's _ disease .
17289052	0	TRPC1	57,62	transient_receptor_potential_canonical_1	15,55	TRPC1	transient receptor potential canonical 1	7220	7220	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of transient_receptor_potential_canonical_1 -LRB- TRPC1 -RRB- in angiotensin_II-induced vascular smooth muscle cell hypertrophy .
24242951	0	TRPC1	48,53	transient_receptor_potential_channel_1	8,46	TRPC1	transient receptor potential channel 1	22063(Tax:10090)	22063(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of transient_receptor_potential_channel_1 -LRB- TRPC1 -RRB- in glutamate-induced cell death in the hippocampal cell line HT22 .
19446005	0	TRPC1	89,94	vascular_endothelial_growth_factor	21,55	TRPC1	vascular endothelial growth factor	7220	7422	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Hypoxia up-regulates vascular_endothelial_growth_factor in U-87 MG cells : involvement of TRPC1 .
12167663	0	TRPC2	48,53	Erythropoietin	0,14	TRPC2	Erythropoietin	22064(Tax:10090)	13856(Tax:10090)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Erythropoietin modulates calcium influx through TRPC2 .
14699131	0	TRPC2	15,20	erythropoietin	34,48	TRPC2	erythropoietin	22064(Tax:10090)	13856(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|modulation modulation|compound|END_ENTITY	Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx .
26554024	0	TRPC3	0,5	ERK	40,43	TRPC3	ERK	7222	5594	Gene	Gene	amplifies|nsubj|START_ENTITY amplifies|dobj|signaling signaling|compound|END_ENTITY	TRPC3 amplifies B cell receptor-induced ERK signaling via protein_kinase_D-dependent Rap1 activation .
21996795	0	TRPC3	41,46	TRPC1	30,35	TRPC3	TRPC1	7222	7220	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and association of TRPC1 with TRPC3 during skeletal myogenesis .
21757714	0	TRPC3	127,132	erythropoietin	147,161	TRPC3	erythropoietin	7222	2056	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nmod|END_ENTITY	The transient receptor potential -LRB- TRP -RRB- channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin .
18177730	0	TRPC3	62,67	transient_receptor_potential_canonical_type_3	15,60	TRPC3	transient receptor potential canonical type 3	7222	7222	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of transient_receptor_potential_canonical_type_3 -LRB- TRPC3 -RRB- channel transcripts with proinflammatory cytokines .
25837939	0	TRPC3	129,134	transient_receptor_potential_subfamily_C_member_3	78,127	TRPC3	transient receptor potential subfamily C member 3	7222	7222	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the rs1465040 single-nucleotide polymorphism close to the transient_receptor_potential_subfamily_C_member_3 -LRB- TRPC3 -RRB- gene and postoperative analgesic requirements .
20164195	0	TRPC4	106,111	SESTD1	33,39	TRPC4	SESTD1	7223	91404	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5 .
17913834	0	TRPC4	25,30	VASP	15,19	TRPC4	VASP	7223	7408	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells .
24563462	0	TRPC4	120,125	transient_receptor_potential_canonical_4	78,118	TRPC4	transient receptor potential canonical 4	22066(Tax:10090)	22066(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Trans-activation_response _ -LRB- TAR -RRB- _ RNA-binding_protein_2 is a novel modulator of transient_receptor_potential_canonical_4 -LRB- TRPC4 -RRB- protein .
26581893	0	TRPC6	0,5	APP	34,37	TRPC6	APP	22068(Tax:10090)	11820(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TRPC6 specifically interacts with APP to inhibit its cleavage by y-secretase and reduce Ab production .
25143325	0	TRPC6	30,35	AngII	83,88	TRPC6	AngII	22068(Tax:10090)	11606(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY induced|nsubj|effects induced|nmod|END_ENTITY	The effects of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII .
26239116	0	TRPC6	66,71	FKBP25	0,6	TRPC6	FKBP25	7225	2287	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	FKBP25 and FKBP38 regulate non-capacitative calcium entry through TRPC6 .
26892346	0	TRPC6	0,5	FSGS	54,58	TRPC6	FSGS	7225	81	Gene	Gene	Associates|compound|START_ENTITY Associates|nmod|END_ENTITY	TRPC6 G757D Loss-of-Function Mutation Associates with FSGS .
20346379	0	TRPC6	66,71	Rab9	15,19	TRPC6	Rab9	7225	9367	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Rab9 and Rab11 in the intracellular trafficking of TRPC6 .
23171048	0	TRPC6	55,60	SNF8	0,4	TRPC6	SNF8	7225	11267	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SNF8 , a member of the ESCRT-II complex , interacts with TRPC6 and enhances its channel activity .
12209856	0	TRPC6	0,5	nitric_oxide_synthase	52,73	TRPC6	nitric oxide synthase	100135637(Tax:10141)	100135576(Tax:10141)	Gene	Gene	colocalized|nsubjpass|START_ENTITY colocalized|nmod|END_ENTITY	TRPC6 immunoreactivity is colocalized with neuronal nitric_oxide_synthase in extrinsic fibers innervating guinea_pig intrinsic cardiac_ganglia .
1472369	0	TRPM-2	46,52	SGP-2	40,45	TRPM-2	SGP-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Developmental expression of the S35-S45 / SGP-2 / TRPM-2 gene in rat testis and epididymis .
7680346	0	TRPM-2	47,53	clusterin	55,64	TRPM-2	clusterin	294329(Tax:10116)	24854(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and expression of the rat TRPM-2 -LRB- clusterin -RRB- gene , a gene implicated in apoptosis .
9010356	0	TRPM-2	100,106	clusterin	108,117	TRPM-2	clusterin	28240(Tax:10090)	12759(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effects of intermittent androgen suppression on the stem cell composition and the expression of the TRPM-2 -LRB- clusterin -RRB- gene in the Shionogi_carcinoma .
8652672	0	TRPM-2	95,101	testosterone-repressed_prostate_message-2	52,93	TRPM-2	testosterone-repressed prostate message-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Modification of the alternative splicing process of testosterone-repressed_prostate_message-2 -LRB- TRPM-2 -RRB- gene by protein synthesis inhibitors and heat_shock treatment .
9415971	0	TRPM-2	103,109	testosterone-repressed_prostate_message-2	60,101	TRPM-2	testosterone-repressed prostate message-2	1191	1191	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Effect of heat shock treatment on the production of variant testosterone-repressed_prostate_message-2 -LRB- TRPM-2 -RRB- mRNA in culture cells .
14744763	0	TRPM1	73,78	MITF	83,87	TRPM1	MITF	4308	4286	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of the melanoma prognostic marker melastatin -LRB- TRPM1 -RRB- by MITF in melanocytes and melanoma .
25760728	0	TRPM2	0,5	Histone_Deacetylase	15,34	TRPM2	Histone Deacetylase	7226	9734	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|compound|END_ENTITY	TRPM2 Mediates Histone_Deacetylase Inhibition-Induced Apoptosis in Bladder_Cancer Cells .
25295536	0	TRPM2	0,5	RAC1	65,69	TRPM2	RAC1	28240(Tax:10090)	19353(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	TRPM2 mediates ischemic_kidney_injury and oxidant stress through RAC1 .
26386353	0	TRPM2	30,35	interleukin-8	62,75	TRPM2	interleukin-8	7226	3576	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 -LRB- CXCL8 -RRB- production by intracellular Fe -LRB- 2 + -RRB- in human monocytic U937 cells .
12529379	0	TRPM2	85,90	transient_receptor_potential_melastatin_2	42,83	TRPM2	transient receptor potential melastatin 2	7226	7226	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Critical intracellular Ca2 + dependence of transient_receptor_potential_melastatin_2 -LRB- TRPM2 -RRB- cation channel activation .
26571400	0	TRPM4	52,57	GLP-1	0,5	TRPM4	GLP-1	54795	100125288	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation .
17293488	0	TRPM4	72,77	Protein_kinase_C	0,16	TRPM4	Protein kinase C	54795	112476	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Protein_kinase_C regulates vascular myogenic tone through activation of TRPM4 .
22291026	0	TRPM4	63,68	SUR1	95,99	TRPM4	SUR1	54795	6833	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nsubj|receptor	On potential interactions between non-selective cation channel TRPM4 and sulfonylurea receptor SUR1 .
16806463	0	TRPM4	0,5	insulin	15,22	TRPM4	insulin	54795	3630	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|secretion secretion|compound|END_ENTITY	TRPM4 controls insulin secretion in pancreatic beta-cells .
21653632	0	TRPM6	47,52	EGF	121,124	TRPM6	EGF	293874(Tax:10116)	25313(Tax:10116)	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment .
27010689	0	TRPM7	14,19	IL-6	32,36	TRPM7	IL-6	54822	3569	Gene	Gene	Function|compound|START_ENTITY Function|nmod|END_ENTITY	Regulation of TRPM7 Function by IL-6 through the JAK2-STAT3 Signaling Pathway .
25426416	0	TRPM7	14,19	MycN	0,4	TRPM7	MycN	54822	4613	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines .
24680379	0	TRPM7	0,5	angiotensin_II	21,35	TRPM7	angiotensin II	54822	183	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	TRPM7 is involved in angiotensin_II induced cardiac fibrosis development by mediating calcium and magnesium influx .
20070945	0	TRPM7	0,5	m-calpain	16,25	TRPM7	m-calpain	54822	824	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun_N-terminal_kinase .
20070945	0	TRPM7	0,5	m-calpain	16,25	TRPM7	m-calpain	54822	824	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun_N-terminal_kinase .
24903376	0	TRPM8	0,5	EMT	67,70	TRPM8	EMT	79054	3702	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	TRPM8 promotes aggressiveness of breast_cancer cells by regulating EMT via activating AKT/GSK -3 b pathway .
23863968	0	TRPM8	45,50	Pirt	0,4	TRPM8	Pirt	171382(Tax:10090)	193003(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Pirt functions as an endogenous regulator of TRPM8 .
26657057	0	TRPM8	62,67	Pirt	47,51	TRPM8	Pirt	79054	644139	Gene	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|regulator regulator|appos|END_ENTITY	Phosphoinositide interacting regulator of TRP -LRB- Pirt -RRB- enhances TRPM8 channel activity in vitro via increasing channel conductance .
17517374	0	TRPM8	17,22	TRPA1	10,15	TRPM8	TRPA1	171384(Tax:10116)	312896(Tax:10116)	Gene	Gene	Increased|nummod|START_ENTITY Increased|nummod|END_ENTITY	Increased TRPA1 , TRPM8 , and TRPV2 expression in dorsal root ganglia by nerve_injury .
18384850	0	TRPM8	58,63	TRPA1	41,46	TRPM8	TRPA1	79054	8989	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|cold cold|dep|END_ENTITY	Differential expression profile of cold -LRB- TRPA1 -RRB- and cool -LRB- TRPM8 -RRB- receptors in human urogenital organs .
23192000	0	TRPM8	15,20	TRPA1	69,74	TRPM8	TRPA1	79054	8989	Gene	Gene	agonist|compound|START_ENTITY 1,8-cineole|appos|agonist antagonist|nsubj|1,8-cineole antagonist|nmod|END_ENTITY	1,8-cineole , a TRPM8 agonist , is a novel natural antagonist of human TRPA1 .
24975826	0	TRPM8	6,11	TRPA1	102,107	TRPM8	TRPA1	79054	8989	Gene	Gene	START_ENTITY|nmod|variant variant|nmod|sensitivity sensitivity|nmod|agonists agonists|appos|R797T R797T|compound|END_ENTITY	Human TRPM8 and TRPA1 pain channels , including a gene variant with increased sensitivity to agonists -LRB- TRPA1 R797T -RRB- , exhibit differential regulation by SRC-tyrosine kinase inhibitor .
22421018	0	TRPM8	101,106	transient_receptor_potential_melastatin_8	58,99	TRPM8	transient receptor potential melastatin 8	171384(Tax:10116)	171384(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	The design and synthesis of novel , phosphonate-containing transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- antagonists .
23411075	0	TRPM8	77,82	transient_receptor_potential_melastatin_8	34,75	TRPM8	transient receptor potential melastatin 8	486170(Tax:9615)	486170(Tax:9615)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Arylglycine derivatives as potent transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- antagonists .
24597733	0	TRPM8	124,129	transient_receptor_potential_melastatin_8	81,122	TRPM8	transient receptor potential melastatin 8	79054	79054	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- antagonists .
22329507	0	TRPM8	114,119	transient_receptor_potential_melastatin_type_8	66,112	TRPM8	transient receptor potential melastatin type 8	171384(Tax:10116)	171384(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Fused piperidines as a novel class of potent and orally available transient_receptor_potential_melastatin_type_8 -LRB- TRPM8 -RRB- antagonists .
16174775	0	TRPM8	95,100	transient_receptor_potential_melastatine_family_member_8	37,93	TRPM8	transient receptor potential melastatine family member 8	79054	79054	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Novel role of cold/menthol-sensitive transient_receptor_potential_melastatine_family_member_8 -LRB- TRPM8 -RRB- in the activation of store-operated channels in LNCaP human prostate_cancer epithelial cells .
22863314	0	TRPML	11,16	TORC1	33,38	TRPML	TORC1	40152(Tax:7227)	47396(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Drosophila TRPML is required for TORC1 activation .
19763610	0	TRPML2	34,40	MCOLN-2	42,49	TRPML2	MCOLN-2	68279(Tax:10090)	68279(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The tissue-specific expression of TRPML2 -LRB- MCOLN-2 -RRB- gene is influenced by the presence of TRPML1 .
24269818	0	TRPML3	17,23	ATG8	66,70	TRPML3	ATG8	55283	11345	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Ca2 + channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy .
17535744	0	TRPP2	0,5	Ca2	7,10	TRPP2	Ca2	5311	760	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	TRPP2 : Ca2 + - permeable cation channel and more .
19153608	0	TRPP2	0,5	Ca2	46,49	TRPP2	Ca2	5311	760	Gene	Gene	channels|compound|START_ENTITY regulate|nsubj|channels regulate|nmod|concentration concentration|amod|END_ENTITY	TRPP2 channels regulate apoptosis through the Ca2 + concentration in the endoplasmic reticulum .
14680804	0	TRPS1	26,31	prostate-specific_antigen	59,84	TRPS1	prostate-specific antigen	7227	354	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	The atypical GATA protein TRPS1 represses androgen-induced prostate-specific_antigen expression in LNCaP_prostate_cancer cells .
22870787	0	TRPV-1	101,107	transient_receptor_potential_vanilloid_1	59,99	TRPV-1	transient receptor potential vanilloid 1	7442	7442	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between single nucleotide polymorphisms of the transient_receptor_potential_vanilloid_1 -LRB- TRPV-1 -RRB- gene and patients with irritable_bowel_syndrome in Korean populations .
18381233	0	TRPV1	36,41	A-kinase_anchoring_protein	0,26	TRPV1	A-kinase anchoring protein	83810(Tax:10116)	498549(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	A-kinase_anchoring_protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 .
16647109	0	TRPV1	8,13	CB1	30,33	TRPV1	CB1	83810(Tax:10116)	25248(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Role of TRPV1 and cannabinoid CB1 receptors in AM_404-evoked hypothermia in rats .
18936104	0	TRPV1	33,38	CB1	61,64	TRPV1	CB1	83810(Tax:10116)	25248(Tax:10116)	Gene	Gene	vanilloid|dep|START_ENTITY receptors|amod|vanilloid receptors|appos|END_ENTITY	Reciprocal changes in vanilloid -LRB- TRPV1 -RRB- and endocannabinoid -LRB- CB1 -RRB- receptors contribute to visceral_hyperalgesia in the water avoidance stressed rat .
18987195	0	TRPV1	125,130	CB1	159,162	TRPV1	CB1	193034(Tax:10090)	12801(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|dep|actions actions|nmod|agonists agonists|nummod|END_ENTITY	Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1 : antinociceptive actions of CB1 inverse agonists .
18987195	0	TRPV1	125,130	CB1	41,44	TRPV1	CB1	193034(Tax:10090)	12801(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY required|nmod|stimulation required|nsubjpass|activity activity|nmod|receptor receptor|compound|END_ENTITY	Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1 : antinociceptive actions of CB1 inverse agonists .
20619260	0	TRPV1	129,134	CB1	78,81	TRPV1	CB1	7442	1268	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Epidermal_growth_factor_receptor transactivation by the cannabinoid receptor -LRB- CB1 -RRB- and transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- induces differential responses in corneal epithelial cells .
22325096	0	TRPV1	50,55	CB1	27,30	TRPV1	CB1	83810(Tax:10116)	25248(Tax:10116)	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|CB2 CB2|compound|END_ENTITY	The effects of cannabinoid CB1 , CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats .
23850608	0	TRPV1	71,76	CB1	0,3	TRPV1	CB1	7442	1268	Gene	Gene	sensitization|nmod|START_ENTITY prevents|dobj|sensitization prevents|nsubj|agonist agonist|nummod|END_ENTITY	CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neurons .
25088915	0	TRPV1	56,61	CB1	14,17	TRPV1	CB1	193034(Tax:10090)	12801(Tax:10090)	Gene	Gene	sensitization|nmod|START_ENTITY inhibits|dobj|sensitization inhibits|nsubj|Activation Activation|nmod|END_ENTITY	Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons .
22325096	0	TRPV1	50,55	CB2	32,35	TRPV1	CB2	83810(Tax:10116)	57302(Tax:10116)	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	The effects of cannabinoid CB1 , CB2 and vanilloid TRPV1 receptor antagonists on cocaine addictive behavior in rats .
26700618	0	TRPV1	12,17	CD4	25,28	TRPV1	CD4	193034(Tax:10090)	12504(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|response response|compound|END_ENTITY	The Role of TRPV1 in the CD4 + T cell-mediated inflammatory response of allergic_rhinitis .
23913765	0	TRPV1	120,125	Calcium-sensing_receptor	0,24	TRPV1	Calcium-sensing receptor	83810(Tax:10116)	24247(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Calcium-sensing_receptor in rat vagal bronchopulmonary sensory neurons regulates the function of the capsaicin receptor TRPV1 .
22427437	0	TRPV1	52,57	Heat_shock_factor_1	0,19	TRPV1	Heat shock factor 1	83810(Tax:10116)	79245(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Heat_shock_factor_1 regulates the expression of the TRPV1 gene in the rat preoptic-anterior hypothalamus area during lipopolysaccharide-induced fever .
22568077	0	TRPV1	55,60	IL-11	26,31	TRPV1	IL-11	7442	3589	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	-LSB- Effects of anandamide on IL-11 production through the TRPV1 of human periodontal ligament cells -RSB- .
26041925	0	TRPV1	77,82	Nerve_Growth_Factor	36,55	TRPV1	Nerve Growth Factor	7442	4803	Gene	Gene	Mechanisms|compound|START_ENTITY Mediated|nmod|Mechanisms Mediated|nsubjpass|Triggered Triggered|nmod|END_ENTITY	Persistent Nociception Triggered by Nerve_Growth_Factor -LRB- NGF -RRB- Is Mediated by TRPV1 and Oxidative Mechanisms .
21473865	0	TRPV1	30,35	Nerve_growth_factor	0,19	TRPV1	Nerve growth factor	83810(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Nerve_growth_factor modulates TRPV1 expression and function and mediates pain in chronic_pancreatitis .
21949864	0	TRPV1	49,54	Nrg1	9,13	TRPV1	Nrg1	193034(Tax:10090)	211323(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Type III Nrg1 back signaling enhances functional TRPV1 along sensory axons contributing to basal and inflammatory thermal pain sensation .
18503554	0	TRPV1	45,50	PKCalpha	59,67	TRPV1	PKCalpha	7442	5578	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Heat-induced MMP-1 expression is mediated by TRPV1 through PKCalpha signaling in HaCaT cells .
16885226	0	TRPV1	20,25	Prolactin	0,9	TRPV1	Prolactin	83810(Tax:10116)	24683(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Prolactin modulates TRPV1 in female rat trigeminal sensory neurons .
24022869	0	TRPV1	20,25	Prolactin	0,9	TRPV1	Prolactin	7442	5617	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Prolactin regulates TRPV1 , TRPA1 , and TRPM8 in sensory neurons in a sex-dependent manner : Contribution of prolactin_receptor to inflammatory_pain .
21645329	0	TRPV1	43,48	Sp1	22,25	TRPV1	Sp1	83810(Tax:10116)	24790(Tax:10116)	Gene	Gene	expression|nummod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons .
15522699	0	TRPV1	26,31	Substance_P	0,11	TRPV1	Substance P	193034(Tax:10090)	21333(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Substance_P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung .
20303589	0	TRPV1	53,58	Substance_P	80,91	TRPV1	Substance P	193034(Tax:10090)	21333(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of genetic deletion of the vanilloid receptor TRPV1 on the expression of Substance_P in sensory neurons of mice with adjuvant-induced_arthritis .
21393555	0	TRPV1	15,20	TLR4	39,43	TRPV1	TLR4	7442	7099	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons .
25139109	0	TRPV1	58,63	TLR4	0,4	TRPV1	TLR4	7442	7099	Gene	Gene	activity|compound|START_ENTITY potentiating|dobj|activity enhances|advcl|potentiating enhances|nsubj|END_ENTITY	TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity .
26424893	0	TRPV1	94,99	TLR4	117,121	TRPV1	TLR4	7442	7099	Gene	Gene	Responses|nmod|START_ENTITY Responses|nmod|Activation Activation|nmod|END_ENTITY	The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4 .
23411401	0	TRPV1	23,28	TNFa	42,46	TRPV1	TNFa	7442	7124	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Thermal stimulation of TRPV1 up-regulates TNFa expression in human periodontal ligament cells .
26171233	0	TRPV1	18,23	TRPA1	42,47	TRPV1	TRPA1	7442	8989	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Propofol restores TRPV1 sensitivity via a TRPA1 - , nitric_oxide_synthase-dependent activation of PKC .
18381233	0	TRPV1	36,41	TRPV1	94,99	TRPV1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	A-kinase_anchoring_protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 .
18381233	0	TRPV1	94,99	TRPV1	36,41	TRPV1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	A-kinase_anchoring_protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1 .
24612851	0	TRPV1	111,116	TRPV1	52,57	TRPV1	TRPV1	193034(Tax:10090)	193034(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Abundant expression and functional participation of TRPV1 at Zusanli acupoint -LRB- ST36 -RRB- in mice : mechanosensitive TRPV1 as an `` acupuncture-responding channel '' .
24612851	0	TRPV1	52,57	TRPV1	111,116	TRPV1	TRPV1	193034(Tax:10090)	193034(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Abundant expression and functional participation of TRPV1 at Zusanli acupoint -LRB- ST36 -RRB- in mice : mechanosensitive TRPV1 as an `` acupuncture-responding channel '' .
24889371	0	TRPV1	105,110	TRPV1	61,66	TRPV1	TRPV1	7442	7442	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Consequences of activating the calcium-permeable ion channel TRPV1 in breast_cancer cells with regulated TRPV1 expression .
24889371	0	TRPV1	61,66	TRPV1	105,110	TRPV1	TRPV1	7442	7442	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Consequences of activating the calcium-permeable ion channel TRPV1 in breast_cancer cells with regulated TRPV1 expression .
26892397	0	TRPV1	72,77	Transient_Receptor_Potential_Cation_Channel_Vanilloid_1	15,70	TRPV1	Transient Receptor Potential Cation Channel Vanilloid 1	193034(Tax:10090)	193034(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Transient_Receptor_Potential_Cation_Channel_Vanilloid_1 -LRB- TRPV1 -RRB- in Myoblast Fusion .
24827675	0	TRPV1	21,26	insulin-like_growth_factor-1	48,76	TRPV1	insulin-like growth factor-1	83810(Tax:10116)	24482(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Enhanced function of TRPV1 via up-regulation by insulin-like_growth_factor-1 in a rat model of bone_cancer_pain .
19286963	0	TRPV1	49,54	nerve_growth_factor	16,35	TRPV1	nerve growth factor	83810(Tax:10116)	310738(Tax:10116)	Gene	Gene	responses|nummod|START_ENTITY augmented|dobj|responses Contribution|acl|augmented Contribution|nmod|END_ENTITY	Contribution of nerve_growth_factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery_occlusion .
25970319	0	TRPV1	116,121	parathyroid_hormone-related_peptide	56,91	TRPV1	parathyroid hormone-related peptide	193034(Tax:10090)	19227(Tax:10090)	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Induction of thermal and mechanical hypersensitivity by parathyroid_hormone-related_peptide through upregulation of TRPV1 function and trafficking .
22878644	0	TRPV1	69,74	substance_P	99,110	TRPV1	substance P	193034(Tax:10090)	21333(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY deletion|nmod|receptor alters|nsubj|deletion alters|dobj|expression expression|compound|END_ENTITY	Quantitative mass spectrometry analysis reveals that deletion of the TRPV1 receptor in mice alters substance_P and neurokinin_A expression in the central nervous system .
23058884	0	TRPV1	90,95	transient_receptor_potential_vanilloid	50,88	TRPV1	transient receptor potential vanilloid	7442	7442	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Discovery of novel pyrrolopyridazine scaffolds as transient_receptor_potential_vanilloid -LRB- TRPV1 -RRB- antagonists .
17660385	0	TRPV1	203,208	transient_receptor_potential_vanilloid-1	161,201	TRPV1	transient receptor potential vanilloid-1	7442	7442	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	-LSB- 3H -RSB- A-778317 -LSB- 1 - -LRB- -LRB- R -RRB- -5 - tert-butyl-indan-1-yl -RRB- -3 - isoquinolin-5-yl-urea -RSB- : a novel , stereoselective , high-affinity antagonist is a useful radioligand for the human transient_receptor_potential_vanilloid-1 -LRB- TRPV1 -RRB- receptor .
15913603	0	TRPV1	60,65	transient_receptor_potential_vanilloid_1	18,58	TRPV1	transient receptor potential vanilloid 1	7442	7442	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- in LNCaP and PC-3_prostate_cancer cells and in human prostate tissue .
16037081	0	TRPV1	56,61	transient_receptor_potential_vanilloid_1	14,54	TRPV1	transient receptor potential vanilloid 1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- by resiniferatoxin .
17560936	0	TRPV1	56,61	transient_receptor_potential_vanilloid_1	14,54	TRPV1	transient receptor potential vanilloid 1	7442	7442	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- in synovial fibroblasts from patients with osteoarthritis and rheumatoid_arthritis .
17937985	0	TRPV1	72,77	transient_receptor_potential_vanilloid_1	30,70	TRPV1	transient receptor potential vanilloid 1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Trisubstituted_pyrimidines as transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists with improved solubility .
18386885	0	TRPV1	90,95	transient_receptor_potential_vanilloid_1	48,88	TRPV1	transient receptor potential vanilloid 1	7442	7442	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Design and synthesis of peripherally restricted transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists .
19344705	0	TRPV1	61,66	transient_receptor_potential_vanilloid_1	19,59	TRPV1	transient receptor potential vanilloid 1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- in the development of acute_visceral_hyperalgesia during colorectal_distension in rats .
20411352	0	TRPV1	54,59	transient_receptor_potential_vanilloid_1	12,52	TRPV1	transient receptor potential vanilloid 1	193034(Tax:10090)	193034(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	The role of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- receptors in dextran sulfate-induced colitis in mice .
20534382	0	TRPV1	52,57	transient_receptor_potential_vanilloid_1	10,50	TRPV1	transient receptor potential vanilloid 1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Effect of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- receptor antagonist compounds SB705498 , BCTC and AMG9810 in rat models of thermal_hyperalgesia measured with an increasing-temperature water bath .
22528458	0	TRPV1	126,131	transient_receptor_potential_vanilloid_1	84,124	TRPV1	transient receptor potential vanilloid 1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Effect of surgical and chemical sensory denervation on non-neural expression of the transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- receptors in the rat .
22957803	0	TRPV1	105,110	transient_receptor_potential_vanilloid_1	63,103	TRPV1	transient receptor potential vanilloid 1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	2 - -LRB- 3-fluoro-4-methylsulfonylaminophenyl -RRB- propanamides as potent transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists : structure-activity relationships of 2-amino derivatives in the N - -LRB- 6-trifluoromethylpyridin-3-ylmethyl -RRB- C-region .
23796768	0	TRPV1	184,189	transient_receptor_potential_vanilloid_1	142,182	TRPV1	transient receptor potential vanilloid 1	7442	7442	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Design and synthesis of conformationally restricted capsaicin analogues based in the 1 , _ 3 , _ 4-thiadiazole heterocycle reveal a novel family of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists .
24340836	0	TRPV1	91,96	transient_receptor_potential_vanilloid_receptor-1	40,89	TRPV1	transient receptor potential vanilloid receptor-1	7442	7442	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the M3151 variant in the transient_receptor_potential_vanilloid_receptor-1 -LRB- TRPV1 -RRB- gene with type 1 diabetes in an Ashkenazi Jewish population .
26563747	0	TRPV1	70,75	transient_receptor_potential_vanilloid_type_1	23,68	TRPV1	transient receptor potential vanilloid type 1	7442	7442	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Dopamine modulation of transient_receptor_potential_vanilloid_type_1 -LRB- TRPV1 -RRB- receptor in dorsal root ganglia neurons .
15857679	0	TRPV1	53,58	vanilloid_receptor_1	31,51	TRPV1	vanilloid receptor 1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and distribution of vanilloid_receptor_1 -LRB- TRPV1 -RRB- in the adult rat brain .
17977643	0	TRPV2	47,52	Transient_receptor_potential_vanilloid_type_2	0,45	TRPV2	Transient receptor potential vanilloid type 2	51393	51393	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transient_receptor_potential_vanilloid_type_2 -LRB- TRPV2 -RRB- expression in normal urothelium and in urothelial_carcinoma of human bladder : correlation with the pathologic stage .
26818531	0	TRPV3	68,73	Sorting_Nexin_11	0,16	TRPV3	Sorting Nexin 11	162514	29916	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|compound|END_ENTITY	Sorting_Nexin_11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3 .
16571723	0	TRPV4	33,38	AQP5	11,15	TRPV4	AQP5	63873(Tax:10090)	11830(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	A role for AQP5 in activation of TRPV4 by hypotonicity : concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery .
16571723	0	TRPV4	33,38	AQP5	81,85	TRPV4	AQP5	63873(Tax:10090)	11830(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY AQP5|nmod|activation role|nmod|AQP5 role|dep|involvement involvement|nmod|END_ENTITY	A role for AQP5 in activation of TRPV4 by hypotonicity : concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery .
22298783	0	TRPV4	78,83	transient_receptor_potential_cation_channel_subfamily_V_member_4	12,76	TRPV4	transient receptor potential cation channel subfamily V member 4	59341	59341	Gene	Gene	Function|appos|START_ENTITY Function|nmod|END_ENTITY	Function of transient_receptor_potential_cation_channel_subfamily_V_member_4 -LRB- TRPV4 -RRB- as a mechanical transducer in flow-sensitive segments of renal collecting duct system .
18355916	0	TRPV4	86,91	transient_receptor_potential_vanilloid_4	44,84	TRPV4	transient receptor potential vanilloid 4	59341	59341	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dependence of regulatory volume decrease on transient_receptor_potential_vanilloid_4 -LRB- TRPV4 -RRB- expression in human corneal epithelial cells .
23288842	0	TRPV4	91,96	transient_receptor_potential_vanilloid_4	49,89	TRPV4	transient receptor potential vanilloid 4	59341	59341	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Protease-activated_receptor_2 -LRB- PAR2 -RRB- protein and transient_receptor_potential_vanilloid_4 -LRB- TRPV4 -RRB- protein coupling is required for sustained inflammatory signaling .
16380433	0	TRPV5	64,69	BSPRY	18,23	TRPV5	BSPRY	194352(Tax:10090)	192120(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity .
16352746	0	TRPV5	77,82	FKBP52	17,23	TRPV5	FKBP52	56302	2288	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	The immunophilin FKBP52 inhibits the activity of the epithelial Ca2 + channel TRPV5 .
18606998	0	TRPV5	73,78	Klotho	33,39	TRPV5	Klotho	56302	9365	Gene	Gene	channel|nummod|START_ENTITY retention|nmod|channel causes|dobj|retention causes|nsubj|Removal Removal|nmod|sialic_acid sialic_acid|nmod|END_ENTITY	Removal of sialic_acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1 .
25378396	0	TRPV5	84,89	Klotho	0,6	TRPV5	Klotho	56302	9365	Gene	Gene	Transient_Receptor_Potential_Vanilloid_5|appos|START_ENTITY Transient_Receptor_Potential_Vanilloid_5|compound|END_ENTITY	Klotho Up-regulates Renal Calcium Channel Transient_Receptor_Potential_Vanilloid_5 -LRB- TRPV5 -RRB- by Intra - and Extracellular N-glycosylation-dependent Mechanisms .
25472266	0	TRPV5	55,60	NCKX3	76,81	TRPV5	NCKX3	194352(Tax:10090)	94249(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
25472266	0	TRPV5	55,60	PMCA1	69,74	TRPV5	PMCA1	194352(Tax:10090)	67972(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
19423690	0	TRPV5	30,35	Parathyroid_hormone	0,19	TRPV5	Parathyroid hormone	56302	5741	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Parathyroid_hormone activates TRPV5 via PKA-dependent phosphorylation .
21737966	0	TRPV5	60,65	TRPV6	67,72	TRPV5	TRPV6	100034071(Tax:9796)	100055509(Tax:9796)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Tissue-specific expression of the calcium transporter genes TRPV5 , TRPV6 , NCX1 , and PMCA1b in the duodenum , kidney and heart of Equus_caballus .
25472266	0	TRPV5	55,60	TRPV6	62,67	TRPV5	TRPV6	194352(Tax:10090)	64177(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
23466996	0	TRPV5	23,28	Uromodulin	0,10	TRPV5	Uromodulin	56302	7369	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis .
16239475	0	TRPV5	59,64	klotho	23,29	TRPV5	klotho	56302	9365	Gene	Gene	channel|compound|START_ENTITY hydrolyzes|dobj|channel hydrolyzes|nsubj|END_ENTITY	The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel .
23970553	0	TRPV5	31,36	klotho	68,74	TRPV5	klotho	56302	9365	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The epithelial calcium channel TRPV5 is regulated differentially by klotho and sialidase .
21576356	0	TRPV5	45,50	parathyroid_hormone	69,88	TRPV5	parathyroid hormone	56302	5741	Gene	Gene	mechanisms|nmod|START_ENTITY mechanisms|nmod|END_ENTITY	Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid_hormone .
23024298	0	TRPV5	25,30	plasmin	8,15	TRPV5	plasmin	56302	5340	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Urinary plasmin inhibits TRPV5 in nephrotic-range proteinuria .
21795703	0	TRPV5	54,59	transient_receptor_potential_vanilloid_5	12,52	TRPV5	transient receptor potential vanilloid 5	56302	56302	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Role of the transient_receptor_potential_vanilloid_5 -LRB- TRPV5 -RRB- protein N terminus in channel activity , tetramerization , and trafficking .
25472266	0	TRPV6	62,67	NCKX3	76,81	TRPV6	NCKX3	64177(Tax:10090)	94249(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
18392847	0	TRPV6	67,72	Nipsnap1	18,26	TRPV6	Nipsnap1	64177(Tax:10090)	18082(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Identification of Nipsnap1 as a novel auxiliary protein inhibiting TRPV6 activity .
25472266	0	TRPV6	62,67	PMCA1	69,74	TRPV6	PMCA1	64177(Tax:10090)	67972(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
16895908	0	TRPV6	42,47	RGS2	0,4	TRPV6	RGS2	55503	5997	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	RGS2 inhibits the epithelial Ca2 + channel TRPV6 .
21737966	0	TRPV6	67,72	TRPV5	60,65	TRPV6	TRPV5	100055509(Tax:9796)	100034071(Tax:9796)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Tissue-specific expression of the calcium transporter genes TRPV5 , TRPV6 , NCX1 , and PMCA1b in the duodenum , kidney and heart of Equus_caballus .
25472266	0	TRPV6	62,67	TRPV5	55,60	TRPV6	TRPV5	64177(Tax:10090)	194352(Tax:10090)	Gene	Gene	CaBP-9k|appos|START_ENTITY CaBP-9k|appos|END_ENTITY	218 DISTINCT EXPRESSION OF CALCIUM TRANSPORT CHANNELS , TRPV5 , TRPV6 , PMCA1 , NCKX3 , AND CaBP-9k IN THE DUODENUM , KIDNEY , AND PLACENTA DURING PREGNANCY .
22205736	0	TRS1	34,38	Beclin_1	83,91	TRS1	Beclin 1	3077523(Tax:10359)	8678	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The human_cytomegalovirus protein TRS1 inhibits autophagy via its interaction with Beclin_1 .
9537512	0	TRUNDD	0,6	TRAIL	28,33	TRUNDD	TRAIL	8793	8743	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	TRUNDD , a new member of the TRAIL receptor family that antagonizes TRAIL signalling .
26038816	0	TRUSS	33,38	Skp2	134,138	TRUSS	Skp2	26133	6502	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2 .
21143527	0	TRX	0,3	fibroblast_growth_factor-2	23,49	TRX	fibroblast growth factor-2	7295	2247	Gene	Gene	up-regulated|nsubj|START_ENTITY up-regulated|advcl|END_ENTITY	TRX is up-regulated by fibroblast_growth_factor-2 in lung_carcinoma .
10781815	0	TRX	29,32	thioredoxin	16,27	TRX	thioredoxin	116484(Tax:10116)	116484(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Upregulation of thioredoxin -LRB- TRX -RRB- expression in giant cell myocarditis in rats .
11407728	0	TRX	19,22	thioredoxin	6,17	TRX	thioredoxin	7295	7295	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum thioredoxin -LRB- TRX -RRB- levels in patients with heart_failure .
21250889	0	TRX	39,42	thioredoxin	26,37	TRX	thioredoxin	7295	7295	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Changes in maternal serum thioredoxin -LRB- TRX -RRB- levels after delivery in preeclamptic and normotensive pregnant women .
16474438	0	TRX	66,69	thioredoxin-1	51,64	TRX	thioredoxin-1	22166(Tax:10090)	22166(Tax:10090)	Gene	Gene	transgenic_mice|appos|START_ENTITY transgenic_mice|amod|END_ENTITY	Redox regulation of mast cell histamine release in thioredoxin-1 -LRB- TRX -RRB- transgenic_mice .
8313910	0	TRX2	29,33	YAP1	0,4	TRX2	YAP1	853123(Tax:4932)	855005(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces_cerevisiae to oxidative stress by hydroperoxides .
22468949	0	TRa1	119,123	STAT3	95,100	TRa1	STAT3	22027(Tax:10090)	20848(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Thyroid hormone promotes neuronal differentiation of embryonic neural stem cells by inhibiting STAT3 signaling through TRa1 .
18834645	0	TRalpha	56,63	ABCD2	95,100	TRalpha	ABCD2	14685(Tax:10090)	26874(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|expression expression|compound|END_ENTITY	Distinct modulatory roles for thyroid hormone receptors TRalpha and TRbeta in SREBP1-activated ABCD2 expression .
17872380	0	TRalpha	36,43	thyroid_hormone_receptor-alpha	4,34	TRalpha	thyroid hormone receptor-alpha	14685(Tax:10090)	21833(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The thyroid_hormone_receptor-alpha -LRB- TRalpha -RRB- gene encoding TRalpha1 controls deoxyribonucleic acid damage-induced tissue repair .
17872380	0	TRalpha1	59,67	thyroid_hormone_receptor-alpha	4,34	TRalpha1	thyroid hormone receptor-alpha	21833(Tax:10090)	21833(Tax:10090)	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	The thyroid_hormone_receptor-alpha -LRB- TRalpha -RRB- gene encoding TRalpha1 controls deoxyribonucleic acid damage-induced tissue repair .
21402532	0	TRb1	54,58	retinoid_X_receptor-a	62,83	TRb1	retinoid X receptor-a	10221	6256	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The cloning , expression and the binding ability with TRb1 of retinoid_X_receptor-a gene -RSB- .
11349124	0	TReP-132	28,36	CBP/p300	52,60	TReP-132	CBP/p300	55809	1387;2033	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression .
10873110	0	TS	36,38	thymidylate_synthase	14,34	TS	thymidylate synthase	22171(Tax:10090)	22171(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Comparison of thymidylate_synthase -LRB- TS -RRB- protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues .
21314984	0	TSA	24,27	Autotaxin	0,9	ATX	Autotaxin	5168	5168	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis .
16806069	0	TSAd	0,4	Smad2	20,25	TSAd	Smad2	9047	4087	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TSAd interacts with Smad2 and Smad3 .
15752554	0	TSAd	50,54	T_cell-specific_adaptor	25,48	TSAd	T cell-specific adaptor	27371(Tax:10090)	27371(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The emerging role of the T_cell-specific_adaptor -LRB- TSAd -RRB- protein as an autoimmune_disease-regulator in mouse and man .
26163016	0	TSAd	33,37	T_cell_specific_adaptor	0,23	TSAd	T cell specific adaptor	9047	27371(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	T_cell_specific_adaptor protein -LRB- TSAd -RRB- promotes interaction of Nck with Lck and SLP-76 in T cells .
26738854	0	TSC-2	138,143	Tuberous_Sclerosis_Complex-2	108,136	TSC-2	Tuberous Sclerosis Complex-2	7249	7249	Gene	Gene	Activation|appos|START_ENTITY Activation|compound|END_ENTITY	Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation_and_Neurodegeneration via Augmented Tuberous_Sclerosis_Complex-2 -LRB- TSC-2 -RRB- Activation in Neuronal Cells .
10906776	0	TSC-22	44,50	TGF-beta	14,22	TSC-22	TGF-beta	21807(Tax:10090)	21803(Tax:10090)	Gene	Gene	stimulated|dobj|START_ENTITY stimulated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of TGF-beta stimulated clone-22 -LRB- TSC-22 -RRB- in mouse development and TGF-beta signalling .
12767908	0	TSC-22	34,40	TGF-beta-stimulated_clone-22	42,70	TSC-22	TGF-beta-stimulated clone-22	8848	8848	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Posttranscriptional regulation of TSC-22 -LRB- TGF-beta-stimulated_clone-22 -RRB- gene by TGF-beta_1 .
12767908	0	TSC-22	34,40	TGF-beta_1	80,90	TSC-22	TGF-beta 1	8848	7040	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Posttranscriptional regulation of TSC-22 -LRB- TGF-beta-stimulated_clone-22 -RRB- gene by TGF-beta_1 .
18325344	0	TSC-22	86,92	fortilin	20,28	TSC-22	fortilin	8848	7178	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between fortilin and transforming_growth_factor-beta_stimulated_clone-22 -LRB- TSC-22 -RRB- prevents apoptosis via the destabilization of TSC-22 .
16959613	0	TSC1	43,47	NF-kappaB	60,69	TSC1	NF-kappaB	7248	4790	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	Essential role of tuberous_sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival .
11329144	0	TSC1	32,36	TGFBR1	24,30	TSC1	TGFBR1	7248	7046	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	The chromosome 9q genes TGFBR1 , TSC1 , and ZNF189 are rarely mutated in bladder_cancer .
16464865	0	TSC1	0,4	TSC2	16,20	TSC1	TSC2	7248	7249	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase .
7762982	0	TSC1	80,84	VAV2	18,22	TSC1	VAV2	7248	7410	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of VAV2 on 9q34 and its exclusion as the tuberous_sclerosis gene TSC1 .
9809973	0	TSC1	51,55	tuberous_sclerosis_1	29,49	TSC1	tuberous sclerosis 1	60445(Tax:10116)	60445(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hamartin , the product of the tuberous_sclerosis_1 -LRB- TSC1 -RRB- gene , interacts with tuberin and appears to be localized to cytoplasmic vesicles .
12820960	0	TSC1_and_2	84,94	Insulin	0,7	TSC1 and 2	Insulin	7248;7249	3630	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|compound|END_ENTITY	Insulin activation of Rheb , a mediator of mTOR/S6K/4E-BP signaling , is inhibited by TSC1_and_2 .
16740698	0	TSC2	65,69	AKT	0,3	TSC2	AKT	7249	207	Gene	Gene	signaling|compound|START_ENTITY proliferation|nmod|signaling enhances|dobj|proliferation enhances|nsubj|activation activation|compound|END_ENTITY	AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling .
25826530	0	TSC2	61,65	AMPK	21,25	TSC2	AMPK	40201(Tax:7227)	43904(Tax:7227)	Gene	Gene	Site|nmod|START_ENTITY Site|compound|END_ENTITY	Identification of an AMPK Phosphorylation Site in Drosophila TSC2 -LRB- gigas -RRB- that Regulate Cell Growth .
18381890	0	TSC2	62,66	FBW5	13,17	TSC2	FBW5	40201(Tax:7227)	33854(Tax:7227)	Gene	Gene	ubiquitination|nmod|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase .
21613414	0	TSC2	46,50	GLUT1	0,5	TSC2	GLUT1	7249	6513	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	GLUT1 enhances mTOR activity independently of TSC2 and AMPK .
16464865	0	TSC2	16,20	TSC1	0,4	TSC2	TSC1	7249	7248	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase .
12957289	0	TSC2	0,4	VEGF	15,19	TSC2	VEGF	7249	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	TSC2 regulates VEGF through mTOR-dependent and - independent pathways .
18056446	0	TSC2	20,24	c-myc	0,5	TSC2	c-myc	7249	4609	Gene	Gene	Repression|nmod|START_ENTITY Repression|amod|END_ENTITY	c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation .
18974095	0	TSC2	41,45	death-associated_protein_kinase	51,82	TSC2	death-associated protein kinase	7249	1612	Gene	Gene	START_ENTITY|nmod|death death|amod|END_ENTITY	Peptide combinatorial libraries identify TSC2 as a death-associated_protein_kinase -LRB- DAPK -RRB- death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling .
14729330	0	TSC2	0,4	mTOR	29,33	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|filling filling|dobj|GAP GAP|nmod|END_ENTITY	TSC2 : filling the GAP in the mTOR signaling pathway .
16391386	0	TSC2	36,40	mTOR	97,101	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	activity|nummod|START_ENTITY regulation|nmod|activity regulation|nmod|pathway pathway|compound|END_ENTITY	Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway .
16816403	0	TSC2	35,39	mTOR	58,62	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|S6 S6|compound|END_ENTITY	AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin_F2alpha .
17671177	0	TSC2	23,27	mTOR	107,111	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY mediated|nsubj|Identification mediated|dobj|activation activation|compound|END_ENTITY	Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous_sclerosis and human cancer .
20145209	0	TSC2	22,26	mTOR	64,68	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	suppresses|nummod|START_ENTITY stabilization|nmod|suppresses tumorigenesis|nsubj|stabilization tumorigenesis|nmod|END_ENTITY	ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway .
20169078	0	TSC2	64,68	mTOR	80,84	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nmod|END_ENTITY	Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR .
21613414	0	TSC2	46,50	mTOR	15,19	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	GLUT1 enhances mTOR activity independently of TSC2 and AMPK .
22492229	0	TSC2	130,134	mTOR	45,49	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY down-regulation|nmod|proteins role|nmod|down-regulation role|appos|END_ENTITY	A role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in glutamate-induced down-regulation of tuberous_sclerosis complex proteins 2 -LRB- TSC2 -RRB- .
23265586	0	TSC2	127,131	mTOR	164,168	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	sclerosis_complex_subunit_2|appos|START_ENTITY expression|nmod|sclerosis_complex_subunit_2 expression|dep|mammalian_target_of_rapamycin mammalian_target_of_rapamycin|dep|END_ENTITY	Enhanced expression of glucose_transporter-1 in vascular smooth muscle cells via the Akt/tuberous _ sclerosis_complex_subunit_2 -LRB- TSC2 -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- / ribosomal S6 protein kinase -LRB- S6K -RRB- pathway in experimental renal_failure .
24398473	0	TSC2	130,134	mTOR	39,43	TSC2	mTOR	7249	21977(Tax:10090)	Gene	Gene	nitrosylation|nmod|START_ENTITY END_ENTITY|nmod|nitrosylation	Inducible nitric_oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2 .
20160076	0	TSC2	15,19	mTORC1	49,55	TSC2	mTORC1	22084(Tax:10090)	382056(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cytoplasm cytoplasm|acl|regulate regulate|dobj|END_ENTITY	ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS .
21886784	0	TSC2	12,16	mTORC1	107,113	TSC2	mTORC1	22084(Tax:10090)	382056(Tax:10090)	Gene	Gene	Ablation|nmod|START_ENTITY enhances|nsubj|Ablation enhances|advcl|increasing increasing|nmod|activation activation|nmod|END_ENTITY	Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 .
22607231	0	TSC2	97,101	mTORC1	77,83	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Natural product-derived antitumor compound phenethyl_isothiocyanate inhibits mTORC1 activity via TSC2 .
25724664	0	TSC2	38,42	mTORC1	109,115	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	Tuberous_Sclerosis_Complex_2|appos|START_ENTITY Loss|nmod|Tuberous_Sclerosis_Complex_2 Frequent|nsubjpass|Loss Frequent|nmod|Everolimus Everolimus|amod|END_ENTITY	Loss of Tuberous_Sclerosis_Complex_2 -LRB- TSC2 -RRB- Is Frequent in Hepatocellular_Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus .
25972538	0	TSC2	38,42	mTORC1	70,76	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	Tuberous_Sclerosis_Complex_Protein_2|appos|START_ENTITY Tuberous_Sclerosis_Complex_Protein_2|dep|Activation Activation|nmod|END_ENTITY	Tuberous_Sclerosis_Complex_Protein_2 -LRB- TSC2 -RRB- - Independent Activation of mTORC1 by Human_Cytomegalovirus pUL38 .
26345496	0	TSC2	0,4	mTORC1	58,64	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inactivation inactivation|nmod|END_ENTITY	TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1 .
26345496	0	TSC2	0,4	mTORC1	58,64	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|inactivation inactivation|nmod|END_ENTITY	TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1 .
26374334	0	TSC2	47,51	mTORC1	60,66	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	Mediated|nmod|START_ENTITY Mediated|nmod|END_ENTITY	Differential IKK/NF-kB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate_Cancer and Tuberous_Sclerosis_Complex_Tumor Cells .
26385560	0	TSC2	92,96	mTORC1	42,48	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	Dynamics|nmod|START_ENTITY Enhance|nmod|Dynamics Enhance|dobj|Activity Activity|amod|END_ENTITY	p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb .
26975632	0	TSC2	52,56	mTORC1	19,25	TSC2	mTORC1	7249	382056(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY signaling|nmod|degradation END_ENTITY|acl|signaling	Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal_cancer .
10732801	0	TSC2	64,68	tuberous_sclerosis_2	42,62	TSC2	tuberous sclerosis 2	7249	7249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation and polymorphism analysis in the tuberous_sclerosis_2 -LRB- TSC2 -RRB- gene .
7558029	0	TSC2	50,54	tuberous_sclerosis_2	28,48	TSC2	tuberous sclerosis 2	7249	7249	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alternative splicing of the tuberous_sclerosis_2 -LRB- TSC2 -RRB- gene in human and mouse tissues .
7972075	0	TSC2	115,119	tuberous_sclerosis_2	93,113	TSC2	tuberous sclerosis 2	24855(Tax:10116)	24855(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Predisposition to renal_carcinoma in the Eker rat is determined by germ-line mutation of the tuberous_sclerosis_2 -LRB- TSC2 -RRB- gene .
15060082	0	TSG-6	0,5	CD44	68,72	TSG-6	CD44	7130	960	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|interaction interaction|nmod|END_ENTITY	TSG-6 modulates the interaction between hyaluronan and cell surface CD44 .
24501198	0	TSG-6	0,5	CXCL8	78,83	TSG-6	CXCL8	7130	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8 .
7876106	0	TSG-6	18,23	NF-IL6	32,38	TSG-6	NF-IL6	7130	1051	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Activation of the TSG-6 gene by NF-IL6 requires two adjacent NF-IL6 binding sites .
22297496	0	TSG-6	0,5	matrix_metalloproteinase_1	47,73	TSG-6	matrix metalloproteinase 1	7130	4312	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|transcription transcription|nmod|END_ENTITY	TSG-6 controls transcription and activation of matrix_metalloproteinase_1 in conjunctivochalasis .
24213015	0	TSG-6	55,60	tumor_necrosis_factor-stimulated_gene-6	14,53	TSG-6	tumor necrosis factor-stimulated gene-6	7130	7130	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Modulation of tumor_necrosis_factor-stimulated_gene-6 -LRB- TSG-6 -RRB- expression in human endometrium .
12622693	0	TSG-6	50,55	tumour_necrosis_factor_stimulated_gene_6	8,48	TSG-6	tumour necrosis factor stimulated gene 6	7130	7130	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of tumour_necrosis_factor_stimulated_gene_6 -LRB- TSG-6 -RRB- in the coupling of inter-alpha-trypsin_inhibitor to hyaluronan in human follicular fluid .
16004603	0	TSG101	78,84	ALG-2	26,31	TSG101	ALG-2	7251	85365	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101 , and Ca2 + - dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B .
18643869	0	TSG101	16,22	GISP	0,4	TSG101	GISP	7251	83998	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation .
14761944	0	TSG101	0,6	apoptosis-antagonizing_transcription_factor	22,65	TSG101	apoptosis-antagonizing transcription factor	7251	26574	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TSG101 interacts with apoptosis-antagonizing_transcription_factor and enhances androgen_receptor-mediated transcription by promoting its monoubiquitination .
23396665	0	TSGA10	36,42	TEX101	44,50	TSGA10	TEX101	80705	83639	Gene	Gene	Genes|nummod|START_ENTITY Genes|nummod|END_ENTITY	Expression of Testis Specific Genes TSGA10 , TEX101 and ODF3 in Breast_Cancer .
8135775	0	TSH-R	35,40	thyrotropin_receptor	13,33	TSH-R	thyrotropin receptor	22095(Tax:10090)	22095(Tax:10090)	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of thyrotropin_receptor -LRB- TSH-R -RRB- autoantibodies and thyroiditis in mice immunised with the recombinant TSH-R .
95622	0	TSH-beta	23,31	TSH-beta	63,71	TSH-beta	TSH-beta	7252	7252	Gene	Gene	START_ENTITY|dep|form form|nmod|END_ENTITY	Large molecular weight TSH-beta : the sole immunoactive form of TSH-beta in certain human sera .
95622	0	TSH-beta	63,71	TSH-beta	23,31	TSH-beta	TSH-beta	7252	7252	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|dep|form	Large molecular weight TSH-beta : the sole immunoactive form of TSH-beta in certain human sera .
2906326	0	TSHB	118,122	NGFB	79,83	TSHB	NGFB	7252	4803	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Two thyroid hormone regulated genes , the beta-subunits of nerve growth factor -LRB- NGFB -RRB- and thyroid stimulating hormone -LRB- TSHB -RRB- , are located less than 310 kb apart in both human and mouse genomes .
2369842	0	TSHB	84,88	thyroid_stimulating_hormone_beta_subunit	42,82	TSHB	thyroid stimulating hormone beta subunit	7252	7252	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosome regional mapping for the human thyroid_stimulating_hormone_beta_subunit -LRB- TSHB -RRB- gene .
2249847	0	TSHR	62,66	thyroid_stimulating_hormone_receptor	24,60	TSHR	thyroid stimulating hormone receptor	7253	7253	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the human thyroid_stimulating_hormone_receptor -LRB- TSHR -RRB- gene to chromosome 14q31 .
15911145	0	TSHR	21,25	thyrotropin_receptor	27,47	TSHR	thyrotropin receptor	7253	7253	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the TSHR -LRB- thyrotropin_receptor -RRB- gene on chromosome 14q31 are not associated with mental_retardation in the iodine-deficient areas of China .
16320156	0	TSHR	113,117	thyrotropin_receptor	91,111	TSHR	thyrotropin receptor	7253	7253	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Mild congenital primary_hypothyroidism in a Turkish family caused by a homozygous missense thyrotropin_receptor -LRB- TSHR -RRB- gene mutation -LRB- A593_V -RRB- .
23329763	0	TSHR	91,95	thyrotropin_receptor	69,89	TSHR	thyrotropin receptor	7253	7253	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mild and severe congenital primary_hypothyroidism in two patients by thyrotropin_receptor -LRB- TSHR -RRB- gene mutation .
8981017	0	TSHR	39,43	thyrotropin_receptor	17,37	TSHR	thyrotropin receptor	7253	7253	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for the thyrotropin_receptor -LRB- TSHR -RRB- as a candidate gene for congenital_hypothyroidism with thyroid_dysgenesis .
18727713	0	TSH_receptor	26,38	TSHr	40,44	TSH receptor	TSHr	7253	7253	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Functional studies of new TSH_receptor -LRB- TSHr -RRB- mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia .
1759034	0	TSH_response_to_TSH-releasing_factor	69,105	GH-releasing_factor	15,34	TSH response to TSH-releasing factor	GH-releasing factor	7200	2691	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	GH response to GH-releasing_factor in dementia and its relation with TSH_response_to_TSH-releasing_factor .
20838640	0	TSHb	127,131	GATA2	118,123	TSHb	GATA2	7252	2624	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Dissecting the Relation between a nuclear receptor and GATA : binding affinity studies of thyroid hormone receptor and GATA2 on TSHb promoter .
18727713	0	TSHr	40,44	TSH_receptor	26,38	TSHr	TSH receptor	7253	7253	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Functional studies of new TSH_receptor -LRB- TSHr -RRB- mutations identified in patients affected by hypothyroidism or isolated hyperthyrotrophinaemia .
9405934	0	TSK	60,63	tight_skin	48,58	TSK	tight skin	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Structure of the mutant fibrillin-1 gene in the tight_skin -LRB- TSK -RRB- mouse .
15535129	0	TSLC1	43,48	tumor_suppressor_in_lung_cancer-1	8,41	TSLC1	tumor suppressor in lung cancer-1	23705	23705	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Loss of tumor_suppressor_in_lung_cancer-1 -LRB- TSLC1 -RRB- expression in meningioma correlates with increased malignancy grade and reduced patient survival .
22851235	0	TSLC1	54,59	tumor_suppressor_in_lung_cancer_1	19,52	TSLC1	tumor suppressor in lung cancer 1	23705	23705	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Down-regulation of tumor_suppressor_in_lung_cancer_1 -LRB- TSLC1 -RRB- expression correlates with poor prognosis in patients with colon_cancer .
23154814	0	TSLP	23,27	Angiotensin_II	0,14	TSLP	Angiotensin II	688621(Tax:10116)	24179(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces TSLP via an AT1 receptor/NF-KappaB pathway , promoting Th17 differentiation .
24966899	0	TSLP	0,4	MCP-1	49,54	TSLP	MCP-1	85480	6347	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	TSLP induced by estrogen stimulates secretion of MCP-1 and IL-8 and growth of human endometrial stromal cells through JNK and NF-kB signal pathways .
22520928	0	TSLP	47,51	TSLP	5,9	TSLP	TSLP	85480	85480	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes .
22520928	0	TSLP	5,9	TSLP	47,51	TSLP	TSLP	85480	85480	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes .
18832669	0	TSLP	47,51	retinoid_X_receptor	66,85	TSLP	retinoid X receptor	85480	6256	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cutting edge : Inhibition of NF-kappaB-mediated TSLP expression by retinoid_X_receptor .
24831437	0	TSLP	100,104	serine_protease_inhibitor_Kazal-type_5	18,56	TSLP	serine protease inhibitor Kazal-type 5	85480	11005	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Epistasis between serine_protease_inhibitor_Kazal-type_5 -LRB- SPINK5 -RRB- and thymic_stromal_lymphopoietin -LRB- TSLP -RRB- genes contributes to childhood asthma .
8566050	0	TSLP	58,62	thymic_stromal-derived_lymphopoietin	20,56	TSLP	thymic stromal-derived lymphopoietin	53603(Tax:10090)	53603(Tax:10090)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of thymic_stromal-derived_lymphopoietin -LRB- TSLP -RRB- in murine B cell development in vitro .
19857905	0	TSLP	53,57	thymic_stromal_lymphopoietin	23,51	TSLP	thymic stromal lymphopoietin	85480	85480	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The regulatory role of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- in maternal-fetal_immune_tolerance during early human pregnancy .
21109412	0	TSLP	42,46	thymic_stromal_lymphopoietin	12,40	TSLP	thymic stromal lymphopoietin	85480	85480	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- in allergic_disorders .
21161346	0	TSLP	38,42	thymic_stromal_lymphopoietin	8,36	TSLP	thymic stromal lymphopoietin	53603(Tax:10090)	53603(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- in palifermin-mediated immune modulation and protection from acute murine graft-versus-host_disease .
24647421	0	TSLP	42,46	thymic_stromal_lymphopoietin	12,40	TSLP	thymic stromal lymphopoietin	85480	85480	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- genotypes on asthma phenotypes defined by the atopy cluster - influence of smoking habits - -RSB- .
22838633	0	TSLPR	62,67	Thymic_Stromal_Lymphopoietin_Receptor	23,60	TSLPR	Thymic Stromal Lymphopoietin Receptor	64109	64109	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	IL-3 and TNFa increase Thymic_Stromal_Lymphopoietin_Receptor -LRB- TSLPR -RRB- expression on eosinophils and enhance TSLP-stimulated degranulation .
21683752	0	TSNAX	63,68	translin-associated_factor_X	28,56	TSNAX	translin-associated factor X	7257	7257	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between translin-associated_factor_X gene -LRB- TSNAX -RRB- and methamphetamine dependence in the Japanese population .
15707585	0	TSP-1	47,52	PTEN	21,25	TSP-1	PTEN	7057	5728	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The tumor suppressor PTEN inhibits EGF-induced TSP-1 and TIMP-1 expression in FTC-133 thyroid_carcinoma cells .
18293192	0	TSP-1	49,54	TGF-beta1	14,23	TSP-1	TGF-beta1	7057	7040	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of TGF-beta1 through up-regulation of TSP-1 by retinoic_acid in retinal pigment epithelial cells .
18555217	0	TSP-1	76,81	TGF-beta1	28,37	TSP-1	TGF-beta1	7057	7040	Gene	Gene	effects|nmod|START_ENTITY mediating|dobj|effects END_ENTITY|acl|mediating	Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells , fibroblasts and oral tumour cells .
12173300	0	TSP-1	35,40	thrombospondin-1	17,33	TSP-1	thrombospondin-1	7057	7057	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Increased plasma thrombospondin-1 -LRB- TSP-1 -RRB- levels are associated with the TNF_alpha-308A allele in children with juvenile_dermatomyositis .
18652777	0	TSP-1	43,48	thrombospondin-1	25,41	TSP-1	thrombospondin-1	445442(Tax:10116)	445442(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of cilostazol on thrombospondin-1 -LRB- TSP-1 -RRB- expression changes in the myocardium of diabetic rats .
19762163	0	TSP-1	101,106	thrombospondin-1	83,99	TSP-1	thrombospondin-1	7057	7057	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- , matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- , and thrombospondin-1 -LRB- TSP-1 -RRB- expression in urothelial_carcinomas .
21333695	0	TSP-1	61,66	thrombospondin-1	43,59	TSP-1	thrombospondin-1	7057	7057	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Role of JNK/ATF -2 pathway in inhibition of thrombospondin-1 -LRB- TSP-1 -RRB- expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells .
15526350	0	TSP-1	63,68	thrombospondin_1	45,61	TSP-1	thrombospondin 1	7057	7057	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- downregulates thrombospondin_1 -LRB- TSP-1 -RRB- expression in thyroid_papillary_carcinoma cells .
25480962	0	TSP-15	10,16	DOXA-1	17,23	TSP-15	DOXA-1	192065(Tax:6239)	182313(Tax:6239)	Gene	Gene	Complex|compound|START_ENTITY Complex|compound|END_ENTITY	The BLI-3 / TSP-15 / DOXA-1 Dual Oxidase Complex Is Required for Iodide Toxicity in Caenorhabditis_elegans .
18193163	0	TSP-5	57,62	COMP	63,67	TSP-5	COMP	1311	1311	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Model systems for studying skeletal_dysplasias caused by TSP-5 / COMP mutations .
17082774	0	TSP1_and_2	65,75	ADAMTS1	0,7	TSP1 and 2	ADAMTS1	108314;104266	11504(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1_and_2 .
10448307	0	TSP2	18,22	Thrombospondin-2	0,16	TSP2	Thrombospondin-2	7058	7058	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Thrombospondin-2 -LRB- TSP2 -RRB- expression is inversely correlated with vascularity in glioma .
12792739	0	TSP2	40,44	thrombospondin_2	22,38	TSP2	thrombospondin 2	7058	7058	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Overexpression of the thrombospondin_2 -LRB- TSP2 -RRB- gene modulated by the matrix metalloproteinase family expression and production in human colon_carcinoma cell line .
25637218	0	TSPAN7	15,21	Tetraspanin_7	0,13	TSPAN7	Tetraspanin 7	7102	7102	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tetraspanin_7 -LRB- TSPAN7 -RRB- expression is upregulated in multiple myeloma patients and inhibits_myeloma_tumour development in vivo .
24692541	0	TSPO	172,176	Translocator_Protein_of_18_kDa	140,170	TSPO	Translocator Protein of 18 kDa	12257(Tax:10090)	12257(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|END_ENTITY	Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor -LRB- Translocator_Protein_of_18_kDa -LRB- TSPO -RRB- -RRB- .
25470454	0	TSPO	0,4	VDAC1	20,25	TSPO	VDAC1	706	7416	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control .
21320609	0	TSPO	61,65	translocator_protein	39,59	TSPO	translocator protein	706	706	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	Age and disease related changes in the translocator_protein -LRB- TSPO -RRB- system in the human brain : positron emission tomography measurements with -LSB- 11C -RSB- vinpocetine .
21417480	0	TSPO	60,64	translocator_protein	38,58	TSPO	translocator protein	12257(Tax:10090)	706	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of the 18 kDa translocator_protein -LRB- TSPO -RRB- by neoplastic and inflammatory cells in mouse tumors of breast_cancer .
23525219	0	TSPO	56,60	translocator_protein	34,54	TSPO	translocator protein	24230(Tax:10116)	24230(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Drug ligand-induced activation of translocator_protein -LRB- TSPO -RRB- stimulates steroid production by aged brown Norway_rat Leydig cells .
25889665	0	TSPO	49,53	translocator_protein	27,47	TSPO	translocator protein	706	706	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Anxiolytic-like effects of translocator_protein -LRB- TSPO -RRB- ligand ZBD-2 in an animal model of chronic_pain .
25889665	0	TSPO	49,53	translocator_protein	27,47	TSPO	translocator protein	706	706	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Anxiolytic-like effects of translocator_protein -LRB- TSPO -RRB- ligand ZBD-2 in an animal model of chronic_pain .
20600583	0	TSPO	43,47	translocator_protein_18_kDa	14,41	TSPO	translocator protein 18 kDa	706	706	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of translocator_protein_18_kDa -LRB- TSPO -RRB- expression in health and disease states .
22348614	0	TSPO	61,65	translocator_protein_18_kDa	32,59	TSPO	translocator protein 18 kDa	706	706	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of the translocator_protein_18_kDa -LRB- TSPO -RRB- in testicular germ cells .
24413569	0	TSPYL2	32,38	GluN2A	90,96	TSPYL2	GluN2A	52808(Tax:10090)	14811(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B .
16314844	0	TSSC5	27,32	UbcH6	49,54	TSSC5	UbcH6	5002	7324	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 .
15964553	0	TSSK5	0,5	CREB	92,96	TSSK5	CREB	283629	1385	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	TSSK5 , a novel member of the testis-specific serine/threonine kinase family , phosphorylates CREB at Ser-133 , and stimulates the CRE/CREB responsive pathway .
2759428	0	TS_PST	78,84	thermostable_phenol_sulfotransferase	40,76	TS PST	thermostable phenol sulfotransferase	6799	6799	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Genetic polymorphism for human platelet thermostable_phenol_sulfotransferase -LRB- TS_PST -RRB- activity .
20410075	0	TTC0482	91,98	MJ1434	28,34	TTC0482	MJ1434	2776011(Tax:262724)	1452338(Tax:243232)	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Helix-hairpin-helix protein MJ1434 from Methanocaldococcus_jannaschii and EndoIV homologue TTC0482 from Thermus_thermophilus_HB27 do not process DNA uracil residues .
26945392	0	TTC37	65,70	Tetratricopeptide_Repeat_Domain_37	29,63	TTC37	Tetratricopeptide Repeat Domain 37	9652	9652	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Identifying Mutations of the Tetratricopeptide_Repeat_Domain_37 -LRB- TTC37 -RRB- Gene in Infants With Intractable Diarrhea and a Comparison of Asian and Non-Asian Phenotype and Genotype : A Global Case-report Study of a Well-Defined Syndrome With Immunodeficiency .
24091941	0	TTC5	6,10	p53	79,82	TTC5	p53	91875	7157	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Human TTC5 , a novel tetratricopeptide repeat domain containing gene , activates p53 and inhibits AP-1 pathway .
15494931	7	TTF-1	1256,1261	CK5	1251,1254	TTF-1	CK7	7270	3855	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Most nonepidermoid tumors had the `` lung-specific '' phenotype CK5 - / TTF-1 + ; all small_cell_carcinomas had the phenotype CK5 - / CK8 + / TTF-1 + , all adenocarcinomas CK5 - / CK7 + / TTF-1 + and -LRB- more than 50 % -RRB- of LCC CK5 - / CK7 + / TTF-1 + .
22582081	0	TTF-1	21,26	CK5	48,51	TTF-1	CK5	7270	3852	Gene	Gene	A|compound|START_ENTITY END_ENTITY|nsubj|A	Dual color multiplex TTF-1 + Napsin A and p63 + CK5 immunostaining for subcategorizing of poorly differentiated pulmonary_non-small_carcinomas into adenocarcinoma and squamous_cell_carcinoma in fine needle aspiration specimens .
22085929	0	TTF-1	35,40	MYBPH	0,5	TTF-1	MYBPH	7270	4608	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	MYBPH , a transcriptional target of TTF-1 , inhibits ROCK1 , and reduces cell motility and metastasis .
16461352	0	TTF-1	22,27	PARP-2	0,6	TTF-1	PARP-2	22130(Tax:10090)	11546(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B .
9006959	1	TTF-1	71,76	Sp1	61,64	TTF-1	Sp1	7270	6667	Gene	Gene	factors|amod|START_ENTITY necessary|nsubj|factors necessary|advmod|END_ENTITY	Sp1 , Sp3 , TTF-1 , and HNF-3alpha transcription factors are necessary for lung cell-specific activation of SP-B gene transcription .
24970044	0	TTF-1	77,82	claudin-6	64,73	TTF-1	claudin-6	22130(Tax:10090)	54419(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1 , Gata-6 , and FoxA2 .
17706597	0	TTF-1	0,5	growth_hormone	16,30	TTF-1	growth hormone	499766(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	TTF-1 regulates growth_hormone and prolactin transcription in the anterior pituitary gland .
12122016	0	TTF-1	87,92	pituitary_adenylate_cyclase-activating_polypeptide	14,64	TTF-1	pituitary adenylate cyclase-activating polypeptide	499766(Tax:10116)	24166(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of pituitary_adenylate_cyclase-activating_polypeptide gene transcription by TTF-1 , a homeodomain-containing transcription factor .
15893507	0	TTHA1554	18,26	glutamine_synthetase	66,86	TTHA1554	glutamine synthetase	3169206(Tax:300852)	3168529(Tax:300852)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Conserved protein TTHA1554 from Thermus_thermophilus_HB8 binds to glutamine_synthetase and cystathionine beta-lyase .
23385749	0	TTHA1607	119,127	thymidylate_kinase	99,117	TTHA1607	thymidylate kinase	3169786(Tax:300852)	3169786(Tax:300852)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Cloning , expression , purification , crystallization and preliminary X-ray crystallographic study of thymidylate_kinase -LRB- TTHA1607 -RRB- from Thermus_thermophilus_HB8 .
26418879	0	TTK	0,3	Akt	14,17	TTK	Akt	7272	207	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TTK activates Akt and promotes proliferation and migration_of_hepatocellular_carcinoma cells .
25763473	0	TTK	64,67	Tyrosine_Threonine_Kinase	37,62	TTK	Tyrosine Threonine Kinase	7272	7272	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	The Discovery of Orally Bioavailable Tyrosine_Threonine_Kinase -LRB- TTK -RRB- Inhibitors : 3 - -LRB- 4 - -LRB- heterocyclyl -RRB- phenyl -RRB- -1 H-indazole-5-carboxamides as Anticancer Agents .
11054573	0	TTLL1	67,72	tubulin_tyrosine_ligase-like_1	30,60	TTLL1	tubulin tyrosine ligase-like 1	25809	25809	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the human tubulin_tyrosine_ligase-like_1 gene -LRB- TTLL1 -RRB- mapping to 22q13 .1 .
23975875	0	TTN	33,36	titin	21,26	TTN	titin	7273	7273	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Recessive truncating titin gene , TTN , mutations presenting as centronuclear_myopathy .
9513081	0	TTN	42,45	triakontatetraneuropeptide	14,40	TTN	triakontatetraneuropeptide	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of the triakontatetraneuropeptide -LRB- TTN -RRB- on corticosteroid secretion by the frog adrenal gland .
22918951	0	TTP	44,47	HIF-1	25,30	TTP	HIF-1	7538	3091	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Multilevel regulation of HIF-1 signaling by TTP .
21875902	0	TTP	50,53	Tristetraprolin	33,48	TTP	Tristetraprolin	7538	7538	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A synonymous polymorphism of the Tristetraprolin -LRB- TTP -RRB- gene , an AU-rich mRNA-binding protein , affects translation efficiency and response to Herceptin treatment in breast_cancer patients .
17517366	0	TTP	43,46	tristetraprolin	26,41	TTP	tristetraprolin	7538	7538	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Comparative expression of tristetraprolin -LRB- TTP -RRB- family member transcripts in normal human tissues and cancer cell lines .
19751836	0	TTR	20,23	Transthyretin	0,13	TTR	Transthyretin	7276	7276	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transthyretin gene -LRB- TTR -RRB- intron 1 elucidates crocodylian phylogenetic relationships .
10675660	0	TTR	60,63	transthyretin	45,58	TTR	transthyretin	7276	7276	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	A new diagnostic procedure to detect unknown transthyretin -LRB- TTR -RRB- mutations in familial_amyloidotic_polyneuropathy -LRB- FAP -RRB- .
1618497	0	TTR	42,45	transthyretin	27,40	TTR	transthyretin	7276	7276	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Molecular diagnosis of the transthyretin -LRB- TTR -RRB- Met111 mutation in familial_amyloid_cardiomyopathy of Danish origin .
27051017	0	TTR	81,84	transthyretin	66,79	TTR	transthyretin	7276	7276	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between a point mutation at the -743 - bp region of the transthyretin -LRB- TTR -RRB- gene and familial_vitreous_amyloidosis .
11597145	0	TTYH2	0,5	tweety	61,67	TTYH2	tweety	94015	33109(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	TTYH2 , a human homologue of the Drosophila_melanogaster gene tweety , is located on 17q24 and upregulated in renal_cell_carcinoma .
18954413	0	TUBA1A	44,50	alpha-1a	26,34	TUBA1A	alpha-1a	7846	773	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Refining the phenotype of alpha-1a Tubulin -LRB- TUBA1A -RRB- mutation in patients with classical_lissencephaly .
9465305	0	TUBA2	74,79	alpha-tubulin	54,67	TUBA2	alpha-tubulin	7278	10376	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence characterization of a newly identified human alpha-tubulin gene -LRB- TUBA2 -RRB- .
26252353	0	TUBB3	6,11	CYP19A1	20,27	TUBB3	CYP19A1	10381	1588	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	TUBB3	6,11	CYP19A1	20,27	TUBB3	CYP19A1	10381	1588	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26842788	0	TUBB3	137,142	ERCC1	118,123	TUBB3	ERCC1	10381	2067	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
22411898	0	TUBB3	5,10	K-Ras	160,165	TUBB3	K-Ras	10381	3845	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	High TUBB3 expression , an independent prognostic marker in patients with early non-small_cell_lung_cancer treated by preoperative chemotherapy , is regulated by K-Ras signaling pathway .
25573098	0	TUBB3	33,38	RRM1	27,31	TUBB3	RRM1	10381	6240	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Expression of ERCC1 , TYMS , RRM1 , TUBB3 , non-muscle myosin II , myoglobin and MyoD1 in lung_adenocarcinoma pleural_effusions predicts survival in patients receiving platinum-based chemotherapy .
26252353	0	TUBB3	6,11	RRM1	0,4	TUBB3	RRM1	10381	6240	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	TUBB3	6,11	RRM1	0,4	TUBB3	RRM1	10381	6240	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|compound|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26842788	0	TUBB3	137,142	RRM1	131,135	TUBB3	RRM1	10381	6240	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
24661907	0	TUBB3	25,30	Sox9	0,4	TUBB3	Sox9	10381	6662	Gene	Gene	expression|nummod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Sox9 and Hif-2a regulate TUBB3 gene expression and affect ovarian_cancer_aggressiveness .
26252353	0	TUBB3	6,11	TOP2A	13,18	TUBB3	TOP2A	10381	7153	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
26252353	0	TUBB3	6,11	TOP2A	13,18	TUBB3	TOP2A	10381	7153	Gene	Gene	CYP2D6|appos|START_ENTITY CYP2D6|appos|END_ENTITY	RRM1 , TUBB3 , TOP2A , CYP19A1 , CYP2D6 : Difference between mRNA and protein expression in predicting prognosis of breast_cancer patients .
25573098	0	TUBB3	33,38	TYMS	21,25	TUBB3	TYMS	10381	7298	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Expression of ERCC1 , TYMS , RRM1 , TUBB3 , non-muscle myosin II , myoglobin and MyoD1 in lung_adenocarcinoma pleural_effusions predicts survival in patients receiving platinum-based chemotherapy .
26842788	0	TUBB3	137,142	TYMS	125,129	TUBB3	TYMS	10381	7298	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
18212821	0	TUCAN	29,34	CARD8	22,27	TUCAN	CARD8	22900	22900	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel isoforms of the CARD8 -LRB- TUCAN -RRB- gene evade a nonsense mutation .
26939244	0	TUMOR_NECROSIS_FACTOR-ALPHA	29,56	TN-ALPHA	58,66	TUMOR NECROSIS FACTOR-ALPHA	TN-ALPHA	7124	7124	Gene	Gene	VALUE|nmod|START_ENTITY VALUE|appos|END_ENTITY	VALUE OF CEREBROSPINAL FLUID TUMOR_NECROSIS_FACTOR-ALPHA -LRB- TN-ALPHA -RRB- FOR RAPID DIAGNOSIS OF BACTERIAL MENINGITIS .
15208665	0	TUSC1	125,130	tumor_suppressor_candidate_1	90,118	TUSC1	tumor suppressor candidate 1	286319	286319	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identifying novel homozygous_deletions by microsatellite analysis and characterization of tumor_suppressor_candidate_1 gene , TUSC1 , on chromosome 9p in human lung_cancer .
26114892	0	TUTase	55,61	Zcchc11	47,54	TUTase	Zcchc11	64852	23318	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Identification of small molecule inhibitors of Zcchc11 TUTase activity .
24376672	0	TWEAK	13,18	APRIL	6,11	TWEAK	APRIL	8742	8741	Gene	Gene	TACI|appos|START_ENTITY TACI|appos|END_ENTITY	BAFF , APRIL , TWEAK , BCMA , TACI and Fn14 proteins are related to human glioma_tumor grade : immunohistochemistry and public microarray data meta-analysis .
24376672	0	TWEAK	13,18	BCMA	20,24	TWEAK	BCMA	8742	608	Gene	Gene	TACI|appos|START_ENTITY TACI|appos|END_ENTITY	BAFF , APRIL , TWEAK , BCMA , TACI and Fn14 proteins are related to human glioma_tumor grade : immunohistochemistry and public microarray data meta-analysis .
26242746	0	TWEAK	21,26	CD163	0,5	TWEAK	CD163	21944(Tax:10090)	93671(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic_injury .
23918987	0	TWEAK	0,5	CD40	30,34	TWEAK	CD40	8742	958	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes .
23918987	0	TWEAK	0,5	CD40	67,71	TWEAK	CD40	8742	958	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|CD40 CD40|acl|signaling signaling|nmod|destabilization destabilization|nmod|END_ENTITY	TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes .
22278019	0	TWEAK	0,5	CXCL16	71,77	TWEAK	CXCL16	8742	58191	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	TWEAK -LRB- tumor_necrosis_factor-like_weak_inducer_of_apoptosis -RRB- activates CXCL16 expression during renal tubulointerstitial_inflammation .
23457623	0	TWEAK	0,5	E-selectin	15,25	TWEAK	E-selectin	21944(Tax:10090)	20339(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	TWEAK enhances E-selectin and ICAM-1 expression , and may contribute to the development of cutaneous_vasculitis .
12821115	0	TWEAK	27,32	Fn14	51,55	TWEAK	Fn14	21944(Tax:10090)	27279(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of murine TWEAK and its receptor -LRB- Fn14 -RRB- by monoclonal antibodies .
26382008	0	TWEAK	18,23	MCP-1	0,5	TWEAK	MCP-1	8742	6347	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	MCP-1 and soluble TWEAK levels are independently associated with coronary_artery_disease severity in patients with chronic_kidney_disease .
26535995	0	TWEAK	26,31	PGC-1a	42,48	TWEAK	PGC-1a	21944(Tax:10090)	19017(Tax:10090)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|expression expression|compound|END_ENTITY	The inflammatory cytokine TWEAK decreases PGC-1a expression and mitochondrial function in acute kidney_injury .
24600451	0	TWEAK	62,67	TNF_Receptor-Associated_Factor_1	0,32	TWEAK	TNF Receptor-Associated Factor 1	8742	7185	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	TNF_Receptor-Associated_Factor_1 is a Major Target of Soluble TWEAK .
19349318	0	TWEAK	71,76	tumor_necrosis_factor-like_weak_inducer_of_apoptosis	17,69	TWEAK	tumor necrosis factor-like weak inducer of apoptosis	8742	8742	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A novel role for tumor_necrosis_factor-like_weak_inducer_of_apoptosis -LRB- TWEAK -RRB- in the development of cardiac_dysfunction and failure .
24916389	0	TWIN-OF-EYELESS	11,26	Clock	30,35	TWIN-OF-EYELESS	Clock	43833(Tax:7227)	38872(Tax:7227)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|compound|END_ENTITY	Effects of TWIN-OF-EYELESS on Clock Gene Expression and Central-Pacemaker Neuron Development in Drosophila .
17258791	0	TWIST	16,21	E-cadherin	58,68	TWIST	E-cadherin	7291	999	Gene	Gene	expression|amod|START_ENTITY Significance|nmod|expression Significance|nmod|END_ENTITY	Significance of TWIST expression and its association with E-cadherin in bladder_cancer .
25313909	0	TWIST	79,84	N-cadherin	93,103	TWIST	N-cadherin	7291	1000	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Gonadotropin_Releasing_Hormone Regulates Human Trophoblastic Cell Invasion via TWIST Induced N-cadherin Expression .
23280703	0	TWIST	0,5	b-catenin	21,30	TWIST	b-catenin	7291	1499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TWIST interacts with b-catenin signaling on osteosarcoma cell survival against cisplatin .
18635960	0	TWIST	0,5	hypoxia_inducible_factor-1	20,46	TWIST	hypoxia inducible factor-1	7291	3091	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	TWIST activation by hypoxia_inducible_factor-1 -LRB- HIF-1 -RRB- : implications in metastasis and development .
24402192	0	TWIST1	0,6	ALDH1	111,116	TWIST1	ALDH1	7291	216	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|nmod|END_ENTITY	TWIST1 and SNAI1 as markers of poor prognosis in human colorectal_cancer are associated with the expression of ALDH1 and TGF-b1 .
22060274	0	TWIST1	24,30	ARTEMIN	0,7	TWIST1	ARTEMIN	7291	9048	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	ARTEMIN synergizes with TWIST1 to promote metastasis and poor survival outcome in patients with ER negative mammary_carcinoma .
26391953	0	TWIST1	24,30	BHLHE40	48,55	TWIST1	BHLHE40	7291	8553	Gene	Gene	Transcription|compound|START_ENTITY Transcription|nmod|END_ENTITY	Regulation Mechanism of TWIST1 Transcription by BHLHE40 and BHLHE41 in Cancer Cells .
26718342	0	TWIST1	39,45	Complement_Component_3	0,22	TWIST1	Complement Component 3	22160(Tax:10090)	12266(Tax:10090)	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|END_ENTITY	Complement_Component_3 Is Regulated by TWIST1 and Mediates Epithelial-Mesenchymal Transition .
23222305	0	TWIST1	0,6	ERK1/2	13,19	TWIST1	ERK1/2	7291	5595;5594	Gene	Gene	effector|nsubj|START_ENTITY effector|compound|END_ENTITY	TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells .
25475555	0	TWIST1	0,6	MYCN	45,49	TWIST1	MYCN	7291	4613	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma .
23368843	0	TWIST1	0,6	NKX3-1	57,63	TWIST1	NKX3-1	7291	4824	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	TWIST1 , A novel androgen-regulated gene , is a target for NKX3-1 in prostate_cancer cells .
22982861	0	TWIST1	30,36	Prospero-related_homeobox_1	45,72	TWIST1	Prospero-related homeobox 1	7291	5629	Gene	Gene	gene|nummod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional repression of TWIST1 gene by Prospero-related_homeobox_1 inhibits invasiveness of hepatocellular_carcinoma cells .
22891766	0	TWIST1	0,6	RELA	37,41	TWIST1	RELA	7291	5970	Gene	Gene	associates|nummod|START_ENTITY associates|nmod|END_ENTITY	TWIST1 associates with NF-kB subunit RELA via carboxyl-terminal WR domain to promote cell autonomous invasion through IL8 production .
27042117	0	TWIST1	94,100	miR-32	0,6	TWIST1	miR-32	7291	407036	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-32 inhibits proliferation , epithelial-mesenchymal transition , and metastasis by targeting TWIST1 in non-small-cell_lung_cancer cells .
21227728	0	TWSG1	77,82	twisted_gastrulation_homolog_1	45,75	TWSG1	twisted gastrulation homolog 1	57045	57045	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Minimal evidence for a direct involvement of twisted_gastrulation_homolog_1 -LRB- TWSG1 -RRB- gene in human holoprosencephaly .
7736322	0	TWY	134,137	parathyroid_hormone	54,73	TWY	parathyroid hormone	18605(Tax:10090)	19226(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Elevation of alkaline phosphatase activity induced by parathyroid_hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY -LRB- twy/twy -RRB- .
19165900	0	TXN2	44,48	thioredoxin_2	29,42	TXN2	thioredoxin 2	25828	25828	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphisms in the thioredoxin_2 -LRB- TXN2 -RRB- gene and risk for spina_bifida .
25870263	0	TXNIP	84,89	Myc	65,68	TXNIP	Myc	10628	4609	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	Metabolic reprogramming in triple-negative breast_cancer through Myc suppression of TXNIP .
25015733	0	TXNIP	0,5	NLRP3	15,20	TXNIP	NLRP3	56338(Tax:10090)	216799(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nummod|END_ENTITY	TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial_ischemia / reperfusion injury .
25726203	0	TXNIP	111,116	THIOREDOXIN_INTERACTING_PROTEIN	78,109	TXNIP	THIOREDOXIN INTERACTING PROTEIN	10628	10628	Gene	Gene	GENE|appos|START_ENTITY GENE|compound|END_ENTITY	GLYCEMIC CONTROL AND OXIDATIVE STRESS MARKERS AND THEIR RELATIONSHIP WITH THE THIOREDOXIN_INTERACTING_PROTEIN -LRB- TXNIP -RRB- GENE IN TYPE 2 DIABETIC PATIENTS .
25854388	0	TXNIP	68,73	Thioredoxin_Interacting_Protein	35,66	TXNIP	Thioredoxin Interacting Protein	10628	10628	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Hypoxia Induced High Expression of Thioredoxin_Interacting_Protein -LRB- TXNIP -RRB- in Non-small_Cell_Lung_Cancer and its Prognostic Effect .
22113441	0	TXNIP	33,38	Thioredoxin_interacting_protein	0,31	TXNIP	Thioredoxin interacting protein	10628	10628	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Thioredoxin_interacting_protein -LRB- TXNIP -RRB- rs7212 polymorphism is associated with arterial stiffness in the Brazilian general population .
12810848	0	TXNIP	49,54	thioredoxin-interacting_protein	16,47	TXNIP	thioredoxin-interacting protein	10628	10628	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Localization of thioredoxin-interacting_protein -LRB- TXNIP -RRB- mRNA in epithelium of human gastrointestinal tract .
22246375	0	TXNIP	48,53	thioredoxin-interacting_protein	15,46	TXNIP	thioredoxin-interacting protein	10628	10628	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of thioredoxin-interacting_protein -LRB- TXNIP -RRB- in glucocorticoid-mediated beta cell death .
26806835	0	TXNIP	62,67	thioredoxin-interacting_protein	29,60	TXNIP	thioredoxin-interacting protein	56338(Tax:10090)	56338(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Epigenetic regulation of the thioredoxin-interacting_protein -LRB- TXNIP -RRB- gene by hyperglycemia in kidney .
17381501	0	TXNIP	54,59	thioredoxin_interacting_protein	21,52	TXNIP	thioredoxin interacting protein	10628	10628	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic variation in thioredoxin_interacting_protein -LRB- TXNIP -RRB- is associated with hypertriglyceridaemia and blood pressure in diabetes_mellitus .
25703281	0	TXNRD2	40,46	thioredoxin_reductase_2	15,38	TXNRD2	thioredoxin reductase 2	10587	10587	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of thioredoxin_reductase_2 -LRB- TXNRD2 -RRB- gene polymorphisms with myocardial_infarction in Slovene patients with type_2_diabetes_mellitus .
24762999	0	TYK2	71,75	JAK3	65,69	TYK2	JAK3	7297	3718	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	-LSB- Effect of arsenic_trioxide and 5-aza-2 ' - deoxycytidine on SHP-1 , JAK3 , TYK2 gene expression in K562 cells -RSB- .
24762999	0	TYK2	71,75	SHP-1	58,63	TYK2	SHP-1	7297	5777	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	-LSB- Effect of arsenic_trioxide and 5-aza-2 ' - deoxycytidine on SHP-1 , JAK3 , TYK2 gene expression in K562 cells -RSB- .
10224114	0	TYK2	65,69	Thrombopoietin	0,14	TYK2	Thrombopoietin	7297	7066	Gene	Gene	JAK2|appos|START_ENTITY requires|dobj|JAK2 requires|nsubj|transduction transduction|compound|END_ENTITY	Thrombopoietin signal transduction requires functional JAK2 , not TYK2 .
19440814	0	TYK2	47,51	tyrosine_kinase_2	28,45	TYK2	tyrosine kinase 2	7297	7297	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of association between tyrosine_kinase_2 -LRB- TYK2 -RRB- gene polymorphisms and susceptibility to SLE in a Japanese population .
26842788	0	TYMS	125,129	ERCC1	118,123	TYMS	ERCC1	7298	2067	Gene	Gene	EGFR|appos|START_ENTITY EGFR|compound|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
25573098	0	TYMS	21,25	RRM1	27,31	TYMS	RRM1	7298	6240	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Expression of ERCC1 , TYMS , RRM1 , TUBB3 , non-muscle myosin II , myoglobin and MyoD1 in lung_adenocarcinoma pleural_effusions predicts survival in patients receiving platinum-based chemotherapy .
26842788	0	TYMS	125,129	RRM1	131,135	TYMS	RRM1	7298	6240	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
25573098	0	TYMS	21,25	TUBB3	33,38	TYMS	TUBB3	7298	10381	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Expression of ERCC1 , TYMS , RRM1 , TUBB3 , non-muscle myosin II , myoglobin and MyoD1 in lung_adenocarcinoma pleural_effusions predicts survival in patients receiving platinum-based chemotherapy .
26842788	0	TYMS	125,129	TUBB3	137,142	TYMS	TUBB3	7298	10381	Gene	Gene	EGFR|appos|START_ENTITY EGFR|appos|END_ENTITY	Combined analysis of rearrangement of ALK , ROS1 , somatic mutation of EGFR , KRAS , BRAF , PIK3CA , and mRNA expression of ERCC1 , TYMS , RRM1 , TUBB3 , EGFR in patients with non-small_cell_lung_cancer and their clinical significance .
15682292	0	TYMS	70,74	thymidylate_synthase	48,68	TYMS	thymidylate synthase	7298	7298	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A common insertion/deletion polymorphism of the thymidylate_synthase -LRB- TYMS -RRB- gene is a determinant of red blood cell folate and homocysteine concentrations .
17018589	0	TYMS	64,68	thymidylate_synthase	42,62	TYMS	thymidylate synthase	7298	7298	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic copy number changes affecting the thymidylate_synthase -LRB- TYMS -RRB- gene in cancer : a model for patient classification to aid fluoropyrimidine therapy .
25762627	0	TYMS	40,44	thymidylate_synthase	18,38	TYMS	thymidylate synthase	7298	7298	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of thymidylate_synthase -LRB- TYMS -RRB- is associated with aggressive_tumor features and early PSA recurrence in prostate_cancer .
20447099	0	TYR	17,20	Tyrosinase	0,10	TYR	Tyrosinase	7299	7299	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tyrosinase gene -LRB- TYR -RRB- mutations in Chinese patients with oculocutaneous_albinism_type_1 .
16573534	0	TYR	76,79	tyrosinase	64,74	TYR	tyrosinase	751100(Tax:9685)	751100(Tax:9685)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Albinism in the domestic_cat -LRB- Felis_catus -RRB- is associated with a tyrosinase -LRB- TYR -RRB- mutation .
7860080	0	TYRP	93,97	tyrosinase_related_protein-1	63,91	TYRP	tyrosinase related protein-1	7306	7306	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Detection of a Tsp509I polymorphism in the 3 ' UTR of the human tyrosinase_related_protein-1 -LRB- TYRP -RRB- gene .
12011806	0	TYRP1	59,64	tyrosinase-related_protein_1	29,57	TYRP1	tyrosinase-related protein 1	7306	7306	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA sequence variants in the tyrosinase-related_protein_1 -LRB- TYRP1 -RRB- gene are not associated with human pigmentary_glaucoma .
25545207	0	T_Cell_Antigen_Receptor	38,61	Alpha-Chain	62,73	T Cell Antigen Receptor	Alpha-Chain	6962	2217	Gene	Gene	Antibody|compound|START_ENTITY Antibody|compound|END_ENTITY	Detection of Constant Domain of Human T_Cell_Antigen_Receptor Alpha-Chain Via Novel Monoclonal Antibody 7F18 .
20621662	0	T_beta_R-II	40,51	Egr-1	24,29	T beta R-II	Egr-1	7048	1958	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Cigarette smoke-induced Egr-1 represses T_beta_R-II expression in human skin dermal fibroblasts .
3284812	0	T_cell-replacing_factor	0,23	interleukin_5	30,43	T cell-replacing factor	interleukin 5	16191(Tax:10090)	16191(Tax:10090)	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	T_cell-replacing_factor -LRB- TRF -RRB- / interleukin_5 -LRB- IL-5 -RRB- : molecular and functional properties .
16446380	0	T_cell-specific_adapter_protein	22,53	LCK	75,78	T cell-specific adapter protein	LCK	27371(Tax:10090)	16818(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Essential role of the T_cell-specific_adapter_protein in the activation of LCK in peripheral T cells .
10975797	0	T_cell-specific_adapter_protein	0,31	Lck	73,76	T cell-specific adapter protein	Lck	9047	3932	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|modulating modulating|dobj|activity activity|compound|END_ENTITY	T_cell-specific_adapter_protein inhibits T cell activation by modulating Lck activity .
15827961	0	T_cell-specific_adapter_protein	18,49	Lck	102,105	T cell-specific adapter protein	Lck	9047	3932	Gene	Gene	terminus|nmod|START_ENTITY necessary|nsubj|terminus necessary|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	The C terminus of T_cell-specific_adapter_protein -LRB- TSAd -RRB- is necessary for TSAd-mediated inhibition of Lck activity .
18541536	0	T_cell-specific_adapter_protein	56,87	Lck	14,17	T cell-specific adapter protein	Lck	9047	3932	Gene	Gene	docking|nmod|START_ENTITY multisite|acl|docking function|nmod|multisite function|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of Lck function through multisite docking to T_cell-specific_adapter_protein .
15752554	0	T_cell-specific_adaptor	25,48	TSAd	50,54	T cell-specific adaptor	TSAd	27371(Tax:10090)	27371(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The emerging role of the T_cell-specific_adaptor -LRB- TSAd -RRB- protein as an autoimmune_disease-regulator in mouse and man .
19913460	0	T_cell_Ig_Mucin-3	15,32	Tim-3	34,39	T cell Ig Mucin-3	Tim-3	171285(Tax:10090)	171285(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of T_cell_Ig_Mucin-3 -LRB- Tim-3 -RRB- in the negative regulation of inflammatory_bowel_disease .
25642819	0	T_cell_antigen_receptor	3,26	CD1a	42,46	T cell antigen receptor	CD1a	6962	909	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	ab T_cell_antigen_receptor recognition of CD1a presenting self lipid ligands .
8006597	0	T_cell_antigen_receptor	86,109	Raf-1	12,17	T cell antigen receptor	Raf-1	6962	5894	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Raf-1 in the regulation of extracellular_signal-regulated_kinase_2 by the T_cell_antigen_receptor .
10318825	0	T_cell_antigen_receptor	20,43	TCR	45,48	T cell antigen receptor	TCR	6962	6962	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Modification of the T_cell_antigen_receptor -LRB- TCR -RRB- complex by UDP-glucose : glycoprotein glucosyltransferase .
10723795	0	T_cell_antigen_receptor	27,50	TCR	52,55	T cell antigen receptor	TCR	6962	6962	Gene	Gene	signalling|compound|START_ENTITY signalling|appos|END_ENTITY	The role of lipid rafts in T_cell_antigen_receptor -LRB- TCR -RRB- signalling .
8046335	0	T_cell_antigen_receptor	21,44	TCR	46,49	T cell antigen receptor	TCR	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|appos|END_ENTITY	Stoichiometry of the T_cell_antigen_receptor -LRB- TCR -RRB- complex : each TCR/CD3 complex contains one TCR_alpha , one TCR_beta , and two CD3_epsilon chains .
10681590	0	T_cell_antigen_receptor-induced_plasma_membrane_targeting_of_SOS_and_Vav	28,100	ZAP-70	0,6	T cell antigen receptor-induced plasma membrane targeting of SOS and Vav	ZAP-70	7409	7535	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	ZAP-70 is essential for the T_cell_antigen_receptor-induced_plasma_membrane_targeting_of_SOS_and_Vav in T cells .
19501050	0	T_cell_death-associated_gene_8	20,50	TDAG8	52,57	T cell death-associated gene 8	TDAG8	299242(Tax:10116)	299242(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Acid-sensing by the T_cell_death-associated_gene_8 -LRB- TDAG8 -RRB- receptor cloned from rat brain .
3487583	0	T_cell_differentiation_antigen	51,81	Lyt-2	45,50	T cell differentiation antigen	Lyt-2	21939(Tax:10090)	12525(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Structure , sequence , and polymorphism of the Lyt-2 T_cell_differentiation_antigen gene .
23649620	0	T_cell_factor	114,127	Numb	144,148	T cell factor	Numb	3172	8650	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/b-catenin signaling to T_cell_factor elements in the Numb promoter .
23649620	0	T_cell_factor	114,127	Numb	59,63	T cell factor	Numb	3172	8650	Gene	Gene	signaling|xcomp|START_ENTITY Wnt/b-catenin|acl|signaling myoblasts|nmod|Wnt/b-catenin END_ENTITY|nmod|myoblasts	Androgens up-regulate transcription of the Notch inhibitor Numb in C2C12 myoblasts via Wnt/b-catenin signaling to T_cell_factor elements in the Numb promoter .
16585583	0	T_cell_factor-1	53,68	CD4	30,33	T cell factor-1	CD4	21414(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|regulation regulation|nmod|END_ENTITY	Transcriptional regulation of CD4 gene expression by T_cell_factor-1 / beta-catenin pathway .
11342639	0	T_cell_factor-1	48,63	Ly-49	96,101	T cell factor-1	Ly-49	21414(Tax:10090)	17055(Tax:10090)	Gene	Gene	START_ENTITY|nmod|acquisition acquisition|nmod|END_ENTITY	Positive and negative roles of the trans-acting T_cell_factor-1 for the acquisition of distinct Ly-49 MHC class I receptors by NK cells .
20980261	0	T_cell_factor_1	26,41	TCF-1	43,48	T cell factor 1	TCF-1	6932	6932	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of suppressive T_cell_factor_1 -LRB- TCF-1 -RRB- isoforms in naive CD4 + T cells is mediated by IL-4 / STAT6 signaling .
6300245	0	T_cell_growth_factor	99,119	TCGF	121,125	T cell growth factor	TCGF	3558	3558	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Viral inhibition of lymphocyte mitogenesis : interference with the synthesis of functionally active T_cell_growth_factor -LRB- TCGF -RRB- activity and reversal of inhibition by the addition of same .
6982926	0	T_cell_growth_factor	110,130	Tac_antigen	27,38	T cell growth factor	Tac antigen	3558	3559	Gene	Gene	interacts|nmod|START_ENTITY expressed|parataxis|interacts expressed|nsubj|significance significance|nmod|END_ENTITY	Functional significance of Tac_antigen expressed on activated human T lymphocytes : Tac_antigen interacts with T_cell_growth_factor in cellular proliferation .
6982926	0	T_cell_growth_factor	110,130	Tac_antigen	83,94	T cell growth factor	Tac antigen	3558	3559	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Functional significance of Tac_antigen expressed on activated human T lymphocytes : Tac_antigen interacts with T_cell_growth_factor in cellular proliferation .
26239720	0	T_cell_immunoglobulin_and_mucin_protein_3	45,86	galectin-9	87,97	T cell immunoglobulin and mucin protein 3	galectin-9	84868	3965	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of immune checkpoint molecules of T_cell_immunoglobulin_and_mucin_protein_3 / galectin-9 for NK cell suppression in human gastrointestinal_stromal_tumors .
24253699	0	T_cell_immunoglobulin_domain_and_mucin-3	20,60	TIM-3	62,67	T cell immunoglobulin domain and mucin-3	TIM-3	84868	84868	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human T_cell_immunoglobulin_domain_and_mucin-3 -LRB- TIM-3 -RRB- on kidney tissue from systemic_lupus_erythematosus -LRB- SLE -RRB- patients .
8093441	0	T_cell_receptor	36,51	CD2	15,18	T cell receptor	CD2	6962	914	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	Alterations of CD2 association with T_cell_receptor signaling molecules in `` CD2 unresponsive '' human T lymphocytes .
2532601	0	T_cell_receptor	44,59	CD3	22,25	T cell receptor	TcR	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Surface expression of CD3 in the absence of T_cell_receptor -LRB- TcR -RRB- : evidence for sorting of partial TcR/CD3 complexes in a post-endoplasmic reticulum compartment .
8814252	0	T_cell_receptor	74,89	CD3/zeta	90,98	T cell receptor	CD3/zeta	6962	919	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T_cell_receptor / CD3/zeta complex .
11157053	0	T_cell_receptor	60,75	CD4	0,3	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	hyperresponsive|xcomp|START_ENTITY T|ccomp|hyperresponsive T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cells from lupus-prone mice are hyperresponsive to T_cell_receptor engagement with low and high affinity peptide antigens : a model to explain spontaneous T cell activation in lupus .
11560989	0	T_cell_receptor	80,95	CD4	28,31	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	engagement|nmod|START_ENTITY induced|nmod|engagement induced|nsubj|cells cells|amod|Anergy Anergy|nmod|END_ENTITY	Anergy in peripheral memory CD4 -LRB- + -RRB- T cells induced by low avidity engagement of T_cell_receptor .
1623924	0	T_cell_receptor	13,28	CD4	70,73	T cell receptor	CD4	6962	920	Gene	Gene	diversity|compound|START_ENTITY diversity|nmod|+ +|compound|END_ENTITY	Specificity , T_cell_receptor diversity and activation requirements of CD4 + and CD8 + clones derived from human melanoma-infiltrating lymphocytes .
1696186	0	T_cell_receptor	75,90	CD4	18,21	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY differences|nmod|expression Subpopulations|dep|differences Subpopulations|nmod|cells cells|nummod|END_ENTITY	Subpopulations of CD4 + cells in lpr/lpr mice : differences in expression of T_cell_receptor / CD3 complex and proliferative responses .
17113120	0	T_cell_receptor	111,126	CD4	107,110	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY ligation|compound|END_ENTITY	Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease : Is CD4 T_cell_receptor ligation needed ?
17113120	0	T_cell_receptor	111,126	CD4	51,54	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	ligation|compound|START_ENTITY needed|nsubjpass|ligation disease|dep|needed mediate|dobj|disease cells|acl:relcl|mediate cells|compound|END_ENTITY	Murine AIDS requires CD154/CD40L expression by the CD4 T cells that mediate retrovirus-induced disease : Is CD4 T_cell_receptor ligation needed ?
2120773	0	T_cell_receptor	14,29	CD4	66,69	T cell receptor	CD4	6962	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|CD8 CD8|compound|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
2120773	0	T_cell_receptor	14,29	CD4	84,87	T cell receptor	CD4	6962	920	Gene	Gene	expression|compound|START_ENTITY Inhibition|nmod|expression +|nsubj|Inhibition +|nmod|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
7679649	0	T_cell_receptor	95,110	CD4	56,59	T cell receptor	CD4	6962	920	Gene	Gene	chain|compound|START_ENTITY epitopes|nmod|chain recognizing|dobj|epitopes cells|acl|recognizing cells|nummod|END_ENTITY	Human T cell autoimmunity against myelin_basic_protein : CD4 + cells recognizing epitopes of the T_cell_receptor beta chain from a myelin_basic_protein-specific T cell clone .
7688792	0	T_cell_receptor	19,34	CD4	63,66	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY peptide-specific|nsubj|involvement peptide-specific|dobj|cells cells|compound|END_ENTITY	The involvement of T_cell_receptor peptide-specific regulatory CD4 + T cells in recovery from antigen-induced autoimmune_disease .
7737291	0	T_cell_receptor	12,27	CD4	60,63	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|targeting targeting|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Intrathymic T_cell_receptor -LRB- TcR -RRB- targeting in mice lacking CD4 or major histocompatibility complex -LRB- MHC -RRB- class II : rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II .
8000034	0	T_cell_receptor	30,45	CD4	93,96	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY commitment|nmod|transgenic_mice commitment|dep|evidence evidence|nmod|precommitment precommitment|nmod|thymocytes thymocytes|compound|END_ENTITY	CD4/CD8 lineage commitment in T_cell_receptor transgenic_mice : evidence for precommitment of CD4 + CD8 + thymocytes .
8920851	0	T_cell_receptor	16,31	CD4	49,52	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Inactivation of T_cell_receptor peptide-specific CD4 regulatory T cells induces chronic experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
9341751	0	T_cell_receptor	14,29	CD4	73,76	T cell receptor	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	signals|nsubj|START_ENTITY signals|dobj|selection selection|nmod|cells cells|nummod|END_ENTITY	Two separable T_cell_receptor signals reconstitute positive selection of CD4 lineage T cells in vivo .
12964124	0	T_cell_receptor	36,51	CD8	89,92	T cell receptor	CD8	6962	925	Gene	Gene	Relevance|nmod|START_ENTITY Relevance|nmod|cytotoxicity cytotoxicity|compound|END_ENTITY	Relevance of peptide avidity to the T_cell_receptor for cytomegalovirus-specific ex vivo CD8 T cell cytotoxicity .
18342010	0	T_cell_receptor	33,48	CD8	54,57	T cell receptor	CD8	6962	925	Gene	Gene	association|nmod|START_ENTITY Restoring|dobj|association Restoring|nmod|END_ENTITY	Restoring the association of the T_cell_receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes .
19534995	0	T_cell_receptor	1,16	CD8	30,33	T cell receptor	CD8	328483(Tax:10090)	925	Gene	Gene	diversity|compound|START_ENTITY diversity|nmod|T T|compound|END_ENTITY	-LSB- T_cell_receptor diversity of CD8 + T lymphocytes and its association with viral load in individuals with HIV-1_infection -RSB- .
2120773	0	T_cell_receptor	14,29	CD8	70,73	T cell receptor	CD8	6962	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of T_cell_receptor expression and function in immature CD4 + CD8 + cells by CD4 .
9653085	0	T_cell_receptor	10,25	CD8	59,62	T cell receptor	CD8	6962	925	Gene	Gene	repertoire|compound|START_ENTITY repertoire|nmod|END_ENTITY	Conserved T_cell_receptor repertoire in primary and memory CD8 T cell responses to an acute viral_infection .
16919488	0	T_cell_receptor	37,52	CXCR4	0,5	T cell receptor	CXCR4	6962	7852	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	CXCR4 physically associates with the T_cell_receptor to signal in T cells .
12665526	0	T_cell_receptor	87,102	Csk	45,48	T cell receptor	Csk	6962	1445	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|regulation regulation|nmod|END_ENTITY	Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T_cell_receptor signaling .
12499424	0	T_cell_receptor	29,44	TCR	46,49	T cell receptor	TCR	6962	6962	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Diagnostic role of tests for T_cell_receptor -LRB- TCR -RRB- genes .
12847689	0	T_cell_receptor	94,109	interleukin-2	122,135	T cell receptor	interleukin-2	6962	3558	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Reconstitution of deficient T_cell_receptor zeta chain restores T cell signaling and augments T_cell_receptor / CD3-induced interleukin-2 production in patients with systemic_lupus_erythematosus .
2526744	0	T_cell_receptor_gamma	31,52	TRG	54,57	T cell receptor gamma	TRG	6965	6965	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Molecular mapping of the human T_cell_receptor_gamma -LRB- TRG -RRB- genes and linkage of the variable and constant regions .
8630073	0	T_cell_receptor_zeta_chain	92,118	Hematopoietic_cell_phosphatase	0,30	T cell receptor zeta chain	Hematopoietic cell phosphatase	919	5777	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Hematopoietic_cell_phosphatase -LRB- HCP -RRB- regulates p56LCK phosphorylation and ZAP-70 binding to T_cell_receptor_zeta_chain .
20305788	0	T_cell_specific_adapter_protein	0,31	ITK	65,68	T cell specific adapter protein	ITK	9047	3702	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	T_cell_specific_adapter_protein -LRB- TSAd -RRB- interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells .
26163016	0	T_cell_specific_adaptor	0,23	TSAd	33,37	T cell specific adaptor	TSAd	27371(Tax:10090)	9047	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	T_cell_specific_adaptor protein -LRB- TSAd -RRB- promotes interaction of Nck with Lck and SLP-76 in T cells .
22392045	0	T_synthase	157,167	galectin-1	189,199	T synthase	galectin-1	94192(Tax:10090)	16852(Tax:10090)	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Knockdown of core 1 beta 1 , 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8 + T cells : T_synthase knockdown effects on galectin-1 and CD8 + T cells .
1975616	0	Ta1	53,56	dipeptidyl_peptidase_IV	60,83	Ta1	dipeptidyl peptidase IV	134864	1803	Gene	Gene	monoclonal|dobj|START_ENTITY monoclonal|nmod|END_ENTITY	Binding of the T cell activation monoclonal antibody Ta1 to dipeptidyl_peptidase_IV .
22140235	0	TaMYB73	61,68	MYB_transcription_factor	30,54	TaMYB73	MYB transcription factor	100873129	100286389(Tax:4565)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Ectopic expression of a wheat MYB_transcription_factor gene , TaMYB73 , improves salinity stress tolerance in Arabidopsis_thaliana .
23017837	0	TaPCS1	59,65	phytochelatin_synthase	30,52	TaPCS1	phytochelatin synthase	542834(Tax:4565)	542834(Tax:4565)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Heteroexpression of the wheat phytochelatin_synthase gene -LRB- TaPCS1 -RRB- in rice enhances cadmium sensitivity .
25604990	0	TaUBA	0,5	UBA	9,12	TaUBA	UBA	100286392(Tax:4565)	100286392(Tax:4565)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	TaUBA , a UBA domain-containing protein in wheat -LRB- Triticum_aestivum_L . -RRB-
3034662	0	Tac_antigen	21,32	CD_25	14,19	Tac antigen	CD 25	3559	3559	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD_25 -LRB- Tac_antigen -RRB- in lymphoid_leukemias and non-Hodgkin_lymphomas .
2993359	0	Tac_antigen	24,35	Interleukin-2	0,13	Tac antigen	Interleukin-2	3559	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Interleukin-2 receptor -LRB- Tac_antigen -RRB- expressed on adult_T_cell_leukemia cells .
6092510	0	Tac_antigen	42,53	Interleukin_2	0,13	Tac antigen	Interleukin 2	3559	3558	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin_2 regulates the expression of Tac_antigen on peripheral blood T lymphocytes .
6982926	0	Tac_antigen	27,38	T_cell_growth_factor	110,130	Tac antigen	T cell growth factor	3559	3558	Gene	Gene	significance|nmod|START_ENTITY expressed|nsubj|significance expressed|parataxis|interacts interacts|nmod|END_ENTITY	Functional significance of Tac_antigen expressed on activated human T lymphocytes : Tac_antigen interacts with T_cell_growth_factor in cellular proliferation .
6982926	0	Tac_antigen	83,94	T_cell_growth_factor	110,130	Tac antigen	T cell growth factor	3559	3558	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Functional significance of Tac_antigen expressed on activated human T lymphocytes : Tac_antigen interacts with T_cell_growth_factor in cellular proliferation .
2581997	0	Tac_antigen	61,72	interleukin-2	83,96	Tac antigen	interleukin-2	3559	3558	Gene	Gene	expression|amod|START_ENTITY expression|appos|receptor receptor|compound|END_ENTITY	Partial restoration of impaired interleukin-2 production and Tac_antigen -LRB- putative interleukin-2 receptor -RRB- expression in patients with acquired_immune_deficiency_syndrome by isoprinosine treatment in vitro .
2787681	0	Tac_antigen	47,58	interleukin-2	23,36	Tac antigen	interleukin-2	3559	3558	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Elevated serum-soluble interleukin-2 receptor -LRB- Tac_antigen -RRB- levels in chronic_myelogenous_leukemia patients with blastic crisis .
2832410	0	Tac_antigen	76,87	interleukin-2	97,110	Tac antigen	interleukin-2	3559	3558	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Sequence requirements for ligand binding and cell surface expression of the Tac_antigen , a human interleukin-2 receptor .
3128947	0	Tac_antigen	42,53	interleukin-2	18,31	Tac antigen	interleukin-2	3559	3558	Gene	Gene	CD25|compound|START_ENTITY Expression|appos|CD25 Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of the interleukin-2 receptor -LRB- Tac_antigen / CD25 -RRB- in hematologic_neoplasms .
3929032	0	Tac_antigen	57,68	interleukin-2	33,46	Tac antigen	interleukin-2	3559	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Biosynthetic processing of human interleukin-2 receptor -LRB- Tac_antigen -RRB- .
6100643	0	Tac_antigen	47,58	interleukin-2	23,36	Tac antigen	interleukin-2	3559	3558	Gene	Gene	expression|appos|START_ENTITY expression|nmod|receptor receptor|compound|END_ENTITY	Abnormal expression of interleukin-2 receptor -LRB- Tac_antigen -RRB- in adult_T-cell_leukemia .
3013994	0	Tac_antigen	69,80	interleukin_1	10,23	Tac antigen	interleukin 1	3559	3552	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin_1 on the expression of interleukin 2 receptor -LRB- Tac_antigen -RRB- on human natural killer cells and natural killer-like cell line -LRB- YT cells -RRB- .
3099287	0	Tac_antigen	42,53	interleukin_2	138,151	Tac antigen	interleukin 2	3559	3558	Gene	Gene	sites|nmod|START_ENTITY essential|nsubj|sites essential|nmod|conformation conformation|nmod|receptor receptor|amod|END_ENTITY	Intracytoplasmic phosphorylation sites of Tac_antigen -LRB- p55 -RRB- are not essential for the conformation , function , and regulation of the human interleukin_2 receptor .
17041011	0	Tachykinin-1_receptor	0,21	NF-kappaB	112,121	Tachykinin-1 receptor	NF-kappaB	6869	4790	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Tachykinin-1_receptor stimulates proinflammatory gene expression in lung epithelial cells through activation of NF-kappaB via a G -LRB- q -RRB- - dependent pathway .
15716051	0	Tacs1	28,33	Terminal_acidic_SANT_1	4,26	Tacs1	Terminal acidic SANT 1	542591(Tax:4577)	542591(Tax:4577)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Terminal_acidic_SANT_1 -LRB- Tacs1 -RRB- gene of maize is expressed in tissues containing meristems and encodes an acidic SANT domain similar to some chromatin-remodeling_complex_proteins .
9707437	0	Tad1p	0,5	ADAR1	103,108	Tad1p	ADAR1	852608(Tax:4932)	103	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	Tad1p , a yeast tRNA-specific_adenosine_deaminase , is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2 .
24082143	0	Taf7l	0,5	Trf2	22,26	Taf7l	Trf2	74469(Tax:10090)	237336(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Taf7l cooperates with Trf2 to regulate spermiogenesis .
9693045	0	Tagln	22,27	sm22alpha	11,20	Tagln	sm22alpha	21345(Tax:10090)	21345(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Paralogous sm22alpha -LRB- Tagln -RRB- genes map to mouse chromosomes 1 and 9 : further evidence for a paralogous relationship .
24894103	0	Takayasu_arteritis	80,98	C-reactive_protein	6,24	C-reactive protein	C-reactive protein	1401	1401	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Serum C-reactive_protein level but not its gene polymorphism is associated with Takayasu_arteritis .
19144723	0	Talpid3	4,11	KIAA0586	18,26	Talpid3	KIAA0586	423540(Tax:9031)	423540(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Talpid3 gene -LRB- KIAA0586 -RRB- encodes a centrosomal protein that is essential for primary cilia formation .
25503683	0	Tamm-Horsfall_Protein	72,93	Tumor_Necrosis_Factor_Alpha	12,39	Tamm-Horsfall Protein	Tumor Necrosis Factor Alpha	22242(Tax:10090)	21926(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nmod|Expression	The Role of Tumor_Necrosis_Factor_Alpha in Regulating the Expression of Tamm-Horsfall_Protein -LRB- Uromodulin -RRB- in Thick Ascending Limbs during Kidney_Injury .
12475993	0	Tankyrase_1	0,11	Mcl-1	27,32	Tankyrase 1	Mcl-1	8658	4170	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|proteins proteins|compound|END_ENTITY	Tankyrase_1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis .
10975834	0	Tap-1	29,34	IFN-gamma	43,52	Tap-1	IFN-gamma	6890	3458	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Synergistic induction of the Tap-1 gene by IFN-gamma and lipopolysaccharide in macrophages is regulated by STAT1 .
11119603	0	Tap-2	54,59	Interferon_regulatory_factor_7	0,30	Tap-2	Interferon regulatory factor 7	6891	3665	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Interferon_regulatory_factor_7 mediates activation of Tap-2 by Epstein-Barr_virus latent membrane protein 1 .
26649283	0	TarP	47,51	Vinculin	0,8	TarP	Vinculin	445347	7414	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane .
12758167	0	Tat	58,61	MCP-1	14,19	Tat	MCP-1	155871(Tax:11676)	6347	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells .
18381601	0	Tat	41,44	SNAP25	14,20	Tat	SNAP25	155871(Tax:11676)	6616	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Inhibition of SNAP25 expression by HIV-1 Tat involves the activity of mir-128a .
12482669	0	Tat	38,41	TNF-alpha	71,80	Tat	TNF-alpha	155871(Tax:11676)	7124	Gene	Gene	triggered|nmod|START_ENTITY triggered|xcomp|induce induce|dobj|END_ENTITY	Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha .
14708348	0	Tat	7,10	TNF-alpha	19,28	Tat	TNF-alpha	155871(Tax:11676)	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	-LSB- HIV-1 Tat induces TNF-alpha production by human monocytes : involvement of calcium and PKC pathways -RSB- .
15264223	0	Tat	72,75	apolipoprotein_E	11,27	Tat	apolipoprotein E	6898	348	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of apolipoprotein_E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes .
22450687	0	Tat	20,23	beta-defensin-2	38,53	Tat	beta-defensin-2	155871(Tax:11676)	1673	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP -1 dependent pathways in human B cells .
9710584	0	Tat-SF1	31,38	CUS2	0,4	Tat-SF1	CUS2	27336	855430(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	CUS2 , a yeast homolog of human Tat-SF1 , rescues function of misfolded U2 through an unusual RNA recognition motif .
19325002	0	Tat-binding_protein-1	0,21	Hop2	174,178	Tat-binding protein-1	Hop2	5702	29893	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Tat-binding_protein-1 -LRB- TBP-1 -RRB- , an ATPase of 19S regulatory particles of the 26S proteasome , enhances androgen_receptor function in cooperation with TBP-1-interacting_protein / Hop2 .
12681485	0	TauT	40,44	WT1	49,52	TauT	WT1	6533	7490	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of taurine transporter gene -LRB- TauT -RRB- by WT1 .
23180277	0	TauT	35,39	taurine_transporter	14,33	TauT	taurine transporter	6533	6533	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of taurine_transporter -LRB- TauT -RRB- is modulated by heat_shock_factor_1 -LRB- HSF1 -RRB- in motor neurons of ALS .
15890932	0	Tax	85,88	ATFx	30,34	Tax	ATFx	1491938(Tax:11908)	22809	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The bZIP transcription factor ATFx binds human_T-cell_leukemia_virus_type_1 _ -LRB- HTLV-1 -RRB- Tax and represses HTLV-1 long terminal repeat-mediated transcription .
24044922	0	Tax	18,21	Bcl-3	0,5	Tax	Bcl-3	1491938(Tax:11908)	602	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Bcl-3 , induced by Tax and HTLV-1 , inhibits NF-kB activation and promotes autophagy .
18815299	0	Tax	36,39	Bcl3	19,23	Tax	Bcl3	1491938(Tax:11908)	602	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The proto-oncogene Bcl3 , induced by Tax , represses Tax-mediated transcription via p300 displacement from the human_T-cell_leukemia_virus_type_1 promoter .
20471052	0	Tax	94,97	Bcl3	108,112	Tax	Bcl3	1491938(Tax:11908)	602	Gene	Gene	Activation|nmod|START_ENTITY increases|nsubj|Activation increases|dobj|expression expression|amod|END_ENTITY	Activation of the PI3K-Akt pathway by human_T_cell_leukemia_virus_type_1 _ -LRB- HTLV-1 -RRB- oncoprotein Tax increases Bcl3 expression , which is associated with enhanced growth of HTLV-1-infected T cells .
23534754	0	Tax	0,3	C/EBP	80,85	Tax	C/EBP	6900	1050	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Tax is involved in up-regulation of HMGB1 expression levels by interaction with C/EBP .
12724399	0	Tax	0,3	CBP/p300	19,27	Tax	CBP/p300	6900	1387;2033	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	Tax recruitment of CBP/p300 , via the KIX domain , reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent .
11809734	0	Tax	35,38	CCL20	95,100	Tax	CCL20	1491938(Tax:11908)	6364	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	Human_T_cell_leukemia_virus_type-I Tax activates human macrophage_inflammatory_protein-3_alpha / CCL20 gene transcription via the NF-kappa_B pathway .
15708600	0	Tax	35,38	CD40	49,53	Tax	CD40	6900	958	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Human_T_cell_leukemia_virus_type_I Tax activates CD40 gene expression via the NF-kappa_B pathway .
26129803	0	Tax	35,38	CD83	65,69	Tax	CD83	6900	9308	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Human T-cell_leukemia_virus_type-I Tax induces the expression of CD83 on T cells .
15107832	0	Tax	35,38	Chk1	115,119	Tax	Chk1	6900	1111	Gene	Gene	interacts|nsubj|START_ENTITY interacts|dobj|G2_arrest G2_arrest|acl|mediated mediated|nmod|END_ENTITY	Human_T-cell_leukemia_virus_type_1 Tax interacts with Chk1 and attenuates DNA-damage induced G2_arrest mediated by Chk1 .
15107832	0	Tax	35,38	Chk1	54,58	Tax	Chk1	6900	1111	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human_T-cell_leukemia_virus_type_1 Tax interacts with Chk1 and attenuates DNA-damage induced G2_arrest mediated by Chk1 .
11080796	0	Tax	49,52	IKKgamma	112,120	Tax	IKKgamma	6900	8517	Gene	Gene	protein|compound|START_ENTITY kinase|nmod|protein kinase|nmod|function function|nmod|END_ENTITY	Activation of I-kappaB kinase by the HTLV type 1 Tax protein : mechanistic insights into the adaptor function of IKKgamma .
11160322	0	Tax	39,42	IL-15R_alpha	53,65	Tax	IL-15R alpha	6900	3601	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Human_T_cell_lymphotropic_virus_type_I Tax activates IL-15R_alpha gene expression through an NF-kappa_B site .
11536160	0	Tax	35,38	IL-4	48,52	Tax	IL-4	6900	3565	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Human T_cell_leukemia virus type I Tax enhances IL-4 gene expression in T cells .
18339896	0	Tax	37,40	IL-9	17,21	Tax	IL-9	1491938(Tax:11908)	3578	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult_T-cell_leukemia cells by a paracrine mechanism .
10482545	0	Tax	142,145	NF-kappaB	83,92	Tax	NF-kappaB	1491938(Tax:11908)	18033(Tax:10090)	Gene	Gene	transfectants|nmod|START_ENTITY transfectants|nsubj|Induction Induction|nmod|expression expression|nmod|type type|dep|END_ENTITY	Induction of Bcl-x -LRB- L -RRB- expression by human T-cell_leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax .
11027516	0	Tax	50,53	NF-kappaB	62,71	Tax	NF-kappaB	1491938(Tax:11908)	4790	Gene	Gene	promoter|nmod|START_ENTITY promoter|nmod|pathway pathway|amod|END_ENTITY	Transactivation of fibronectin promoter by HTLV-I Tax through NF-kappaB pathway .
17942533	0	Tax	39,42	NF-kappaB	107,116	Tax	NF-kappaB	6900	4790	Gene	Gene	oncoprotein|compound|START_ENTITY requires|nsubj|oncoprotein requires|dobj|Ubc13 Ubc13|nmod|activation activation|amod|END_ENTITY	The human T-cell_leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation .
18425496	0	Tax	140,143	NF-kappaB	19,28	Tax	NF-kappaB	6900	4790	Gene	Gene	oncogenicity|compound|START_ENTITY mechanism|nmod|oncogenicity HTLV-1|dep|mechanism HTLV-1|acl:relcl|enhanced enhanced|nsubjpass|activation activation|amod|END_ENTITY	HTLV-1 tax-induced NF-kappaB activation is synergistically enhanced by 12-O-tetradecanoylphorbol-13-acetate : mechanism and implications for Tax oncogenicity .
18504428	0	Tax	118,121	NF-kappaB	51,60	Tax	NF-kappaB	1491938(Tax:11908)	4790	Gene	Gene	induced|nmod|START_ENTITY progression|acl|induced critical|nmod|progression critical|nsubj|Activation Activation|nmod|genes genes|nmod|END_ENTITY	Activation of the cyclin_D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax .
19129196	0	Tax	7,10	NF-kappaB	124,133	Tax	NF-kappaB	6900	4790	Gene	Gene	modulator|nsubj|START_ENTITY modulator|acl:relcl|hijacks hijacks|nmod|microdomains microdomains|nmod|activation activation|nmod|END_ENTITY	HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB .
9658126	0	Tax	56,59	NF-kappaB	67,76	Tax	NF-kappaB	1491938(Tax:11908)	4790	Gene	Gene	forms|nmod|START_ENTITY induce|nsubj|forms induce|dobj|activation activation|amod|END_ENTITY	Cytoplasmic forms of human_T-cell_leukemia_virus_type_1 Tax induce NF-kappaB activation .
9710600	0	Tax	35,38	NF-kappaB	52,61	Tax	NF-kappaB	6900	4790	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Human_T-cell_leukemia_virus_type_1 Tax induction of NF-kappaB involves activation of the IkappaB_kinase_alpha -LRB- IKKalpha -RRB- and IKKbeta cellular kinases .
11160322	0	Tax	39,42	NF-kappa_B	93,103	Tax	NF-kappa B	6900	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|site site|amod|END_ENTITY	Human_T_cell_lymphotropic_virus_type_I Tax activates IL-15R_alpha gene expression through an NF-kappa_B site .
8627811	0	Tax	30,33	NF1	18,21	Tax	NF1	1491938(Tax:11908)	4763	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Repression of the NF1 gene by Tax may expain the development of neurofibromas in human_T-lymphotropic_virus_type_1 transgenic_mice .
8613423	0	Tax	93,96	OX40	13,17	Tax	OX40	1491938(Tax:11908)	7293	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of OX40 , a receptor of gp34 , on T cells by trans-acting transcriptional activator , Tax , of human_T-cell_leukemia_virus_type_I .
21994792	0	Tax	69,72	RNAse_T2	21,29	Tax	RNAse T2	1491938(Tax:11908)	8635	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Direct inhibition of RNAse_T2 expression by the HTLV-1 viral protein Tax .
22106342	0	Tax	106,109	RNF4	35,39	Tax	RNF4	6900	6047	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax .
21054678	0	Tax	28,31	SMYD3	0,5	Tax	SMYD3	1491938(Tax:11908)	64754	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SMYD3 interacts with HTLV-1 Tax and regulates subcellular localization of Tax .
16409643	0	Tax	30,33	SUV39H1	0,7	Tax	SUV39H1	1491938(Tax:11908)	6839	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SUV39H1 interacts with HTLV-1 Tax and abrogates Tax transactivation of HTLV-1 LTR .
16767081	0	Tax	27,30	TAX1BP2	75,82	Tax	TAX1BP2	6900	55697	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The retroviral oncoprotein Tax targets the coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication .
16403915	0	Tax	7,10	c-FLIP	107,113	Tax	c-FLIP	1491938(Tax:11908)	8837	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|induction induction|nmod|END_ENTITY	HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular_FLICE-inhibitory_protein -LRB- c-FLIP -RRB- .
9765496	0	Tax	51,54	c-Myb	96,101	Tax	c-Myb	1491938(Tax:11908)	4602	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	The human_T-cell_leukemia_virus_type_1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB_binding_protein .
8510222	0	Tax	139,142	c-rel	130,135	Tax	c-rel	1491938(Tax:11908)	5966	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Differential expression of Rel family members in human T-cell_leukemia_virus_type_I-infected cells : transcriptional activation of c-rel by Tax protein .
9668114	0	Tax	60,63	cAMP-responsive_element-binding_protein	73,112	Tax	cAMP-responsive element-binding protein	6900	1385	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	The human T-cell_leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive_element-binding_protein -LRB- CREB -RRB- binding activity through interactions with the DNA minor groove .
17395420	0	Tax	22,25	calreticulin	39,51	Tax	calreticulin	1491938(Tax:11908)	811	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Interaction of HTLV-1 Tax protein with calreticulin : implications for Tax nuclear export and secretion .
11314046	0	Tax	76,79	cyclin_D2	37,46	Tax	cyclin D2	6900	894	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Direct trans-activation of the human cyclin_D2 gene by the oncogene product Tax of human_T-cell_leukemia_virus_type_I .
11160720	0	Tax	80,83	cyclin_a	33,41	Tax	cyclin a	6900	890	Gene	Gene	protein|compound|START_ENTITY repression|nmod|protein repression|nmod|END_ENTITY	CREB/ATF-dependent repression of cyclin_a by human_T-cell_leukemia_virus_type_1 Tax protein .
19032754	0	Tax	45,48	galectin-1	13,23	Tax	galectin-1	1491938(Tax:11908)	3956	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity .
16557588	0	Tax	35,38	interleukin-6_receptor	61,83	Tax	interleukin-6 receptor	6900	3570	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Human_T-cell_leukemia_virus_type-I Tax induces expression of interleukin-6_receptor -LRB- IL-6R -RRB- : Shedding of soluble IL-6R and activation of STAT3 signaling .
8510934	0	Tax	47,50	interleukin_3	54,67	Tax	interleukin 3	6900	3562	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Differential effect of HTLV_infection and HTLV Tax on interleukin_3 expression .
11809734	0	Tax	35,38	macrophage_inflammatory_protein-3_alpha	55,94	Tax	macrophage inflammatory protein-3 alpha	1491938(Tax:11908)	6364	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	Human_T_cell_leukemia_virus_type-I Tax activates human macrophage_inflammatory_protein-3_alpha / CCL20 gene transcription via the NF-kappa_B pathway .
10381170	0	Tax	12,15	nuclear_respiratory_factor_1	69,97	Tax	nuclear respiratory factor 1	6900	4899	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	HTLV type I Tax activation of the CXCR4 promoter by association with nuclear_respiratory_factor_1 .
8414497	0	Tax	15,18	p105	60,64	Tax	p105	6900	4790	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	HTLV-I encoded Tax in association with NF-kappa_B precursor p105 enhances nuclear localization of NF-kappa_B_p50 and p65 in transfected cells .
8612584	0	Tax	7,10	p16INK4A	68,76	Tax	p16INK4A	6900	1029	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4 .
9209282	0	Tax	7,10	p16Ink4a	68,76	Tax	p16Ink4a	6900	1029	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16Ink4a and counteracts its inhibitory activity to CDK4 .
19356250	0	Tax	76,79	p21	13,16	Tax	p21	6900	1026	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of p21 -LRB- CIP1/WAF1 -RRB- expression by human_T-lymphotropic_virus_type_1 Tax requires transcriptional activation and mRNA stabilization .
8764097	0	Tax	64,67	p21	77,80	Tax	p21	1491938(Tax:11908)	1026	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	A cooperative interaction of human_T-cell_leukemia_virus_type_1 Tax with the p21 cyclin-dependent kinase inhibitor activates the human_immunodeficiency_virus_type_1 enhancer .
10766811	0	Tax	125,128	p300	0,4	Tax	p300	1491938(Tax:11908)	2033	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	p300 and p300/cAMP-responsive element-binding protein associated factor interact with human_T-cell_lymphotropic_virus_type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex .
10931836	0	Tax	64,67	p53	95,98	Tax	p53	1491938(Tax:11908)	7157	Gene	Gene	repair|nmod|START_ENTITY Suppression|nmod|repair rescued|nsubj|Suppression rescued|nmod|END_ENTITY	Suppression of DNA repair by human T_cell_leukemia_virus_type_1 Tax is rescued by a functional p53 signaling pathway .
11036071	0	Tax	34,37	p53	77,80	Tax	p53	6900	7157	Gene	Gene	protein|compound|START_ENTITY utilizes|nsubj|protein utilizes|dobj|pathways pathways|nmod|inhibition inhibition|compound|END_ENTITY	Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent .
11080808	0	Tax	71,74	p53	41,44	Tax	p53	6900	7157	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Insights Insights|nmod|mechanism mechanism|nmod|END_ENTITY	Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax .
11160722	0	Tax	69,72	p53	12,15	Tax	p53	1491938(Tax:11908)	22060(Tax:10090)	Gene	Gene	model|compound|START_ENTITY Analysis|nmod|model Analysis|nmod|inactivation inactivation|compound|END_ENTITY	Analysis of p53 inactivation in a human_T-cell_leukemia_virus_type_1 Tax transgenic mouse model .
15155458	0	Tax	7,10	p53	94,97	Tax	p53	6900	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|interaction interaction|acl:relcl|results results|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity .
15569630	0	Tax	45,48	p53	63,66	Tax	p53	1491938(Tax:11908)	7157	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Setting the stage for transformation : HTLV-1 Tax inhibition of p53 function .
15994832	0	Tax	127,130	p53	58,61	Tax	p53	1491938(Tax:11908)	7157	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|repression repression|nmod|activity activity|nmod:poss|END_ENTITY	Evidence for NF-kappaB - and CBP-independent repression of p53 's transcriptional activity by human_T-cell_leukemia_virus_type_1 Tax in mouse embryo and primary human fibroblasts .
16308315	0	Tax	69,72	p53	27,30	Tax	p53	6900	7157	Gene	Gene	protein|compound|START_ENTITY type|dep|protein END_ENTITY|nmod|type	Functional inactivation of p53 by human T-cell_leukemia virus type 1 Tax protein : mechanisms and clinical implications .
23633516	0	Tax	107,110	p53	0,3	Tax	p53	21367(Tax:10090)	22060(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY mice|acl|expressing progression|nmod|mice precedes|nmod|progression precedes|nsubj|dysfunction dysfunction|compound|END_ENTITY	p53 dysfunction precedes the activation of nuclear factor-kB during disease progression in mice expressing Tax , a human T-cell_leukemia virus type 1 oncoprotein .
7499359	0	Tax	72,75	p53	30,33	Tax	p53	6900	7157	Gene	Gene	protein|compound|START_ENTITY repression|nmod|protein repression|nmod|END_ENTITY	Transcriptional repression of p53 by human T-cell_leukemia virus type I Tax protein .
9445014	0	Tax	89,92	p53	14,17	Tax	p53	1491938(Tax:11908)	7157	Gene	Gene	protein|compound|START_ENTITY function|nmod|protein function|nsubj|Inhibition Inhibition|nmod|transactivation transactivation|compound|END_ENTITY	Inhibition of p53 transactivation function by the human_T-cell_lymphotropic_virus_type_1 Tax protein .
18422743	0	Tax	43,46	telomerase_reverse_transcriptase	74,106	Tax	telomerase reverse transcriptase	1491938(Tax:11908)	7015	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|gene gene|amod|END_ENTITY	Role of human_T-cell_leukemia_virus_type_I Tax in expression of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in human T-cells .
10212281	1	Tax1	139,143	Ets1	77,81	Tax1	Ets1	6900	2113	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Ets1 and Ets2 , but not Elf-1 , cooperate with GATA3 and HTLV-I Tax1 .
8642682	0	Tax1	39,43	NF-kappa_B	58,68	Tax1	NF-kappa B	6900	4790	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Human_T-cell_lymphotropic_virus_type_1 Tax1 activation of NF-kappa_B : involvement of the protein_kinase_C pathway .
8970974	0	Tax1	87,91	intercellular_adhesion_molecule_1	36,69	Tax1	intercellular adhesion molecule 1	6900	3383	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Differential transactivation of the intercellular_adhesion_molecule_1 gene promoter by Tax1 and Tax2 of human T-cell_leukemia viruses .
17216190	0	Taxol-resistance-associated_gene-3	0,34	CSAG2	43,48	Taxol-resistance-associated gene-3	CSAG2	102723547	102723547	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Taxol-resistance-associated_gene-3 -LRB- TRAG-3 / CSAG2 -RRB- expression is predictive for clinical outcome in ovarian_carcinoma patients .
15580499	0	Taxol_resistance-associated_gene-3	63,97	TRAG-3	99,105	Taxol resistance-associated gene-3	TRAG-3	102723547	102723547	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Spontaneous T-cell responses against peptides derived from the Taxol_resistance-associated_gene-3 -LRB- TRAG-3 -RRB- protein in cancer patients .
19918778	0	Tbata	9,14	Spatial	0,7	Tbata	Spatial	65971(Tax:10090)	65971(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Spatial -LRB- Tbata -RRB- expression in mature medullary thymic_epithelial_cells .
12446740	0	Tbce	55,59	tubulin-specific_chaperone_E	25,53	Tbce	tubulin-specific chaperone E	70430(Tax:10090)	70430(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Missense mutation in the tubulin-specific_chaperone_E -LRB- Tbce -RRB- gene in the mouse mutant progressive motor_neuronopathy , a model of human motoneuron_disease .
9346908	0	TbetaRI	0,7	Smad2	27,32	TbetaRI	Smad2	7046	4087	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling .
17203972	0	TbetaRI	64,71	transforming_growth_factor-beta	15,46	TbetaRI	transforming growth factor-beta	7046	7040	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Interactome of transforming_growth_factor-beta type I receptor -LRB- TbetaRI -RRB- : inhibition of TGFbeta signaling by Epac1 .
21172820	0	TbetaRII	106,114	ERK1/2	47,53	TbetaRII	ERK1/2	7048	5595;5594	Gene	Gene	expression|compound|START_ENTITY levels|nmod|expression signaling|nmod|levels signaling|nmod|END_ENTITY	TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression .
21172820	0	TbetaRII	25,33	ERK1/2	47,53	TbetaRII	ERK1/2	7048	5595;5594	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression .
18097622	0	TbetaR_I	48,56	TGF-beta1	14,23	TbetaR I	TGF-beta1	7046	7040	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of TGF-beta1 and its receptor genes -LRB- TbetaR_I , TbetaR_II , and TbetaR_III-betaglycan -RRB- in peripheral blood leucocytes in patients with idiopathic_pulmonary_arterial_hypertension and Eisenmenger 's _ syndrome .
26376340	0	Tbk1	61,65	Optineurin	163,173	Tbk1	Optineurin	29110	10133	Gene	Gene	Activates|dobj|START_ENTITY Activates|nmod|Formation Formation|nmod|Phosphorylation Phosphorylation|nmod|END_ENTITY	A Glaucoma-Associated Variant of Optineurin , M98K , Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin .
26376340	0	Tbk1	61,65	Optineurin	33,43	Tbk1	Optineurin	29110	10133	Gene	Gene	Activates|dobj|START_ENTITY Activates|nsubj|Variant Variant|nmod|M98K M98K|compound|END_ENTITY	A Glaucoma-Associated Variant of Optineurin , M98K , Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin .
9511831	0	TbpA	128,132	transferrin	43,54	TbpA	transferrin	7276	7018	Gene	Gene	proteins|appos|START_ENTITY binding|nmod|proteins binding|nmod|END_ENTITY	Differential binding of apo and holo human transferrin to meningococci and co-localisation of the transferrin-binding proteins -LRB- TbpA and TbpB -RRB- .
9766237	0	TbpA	78,82	transferrin	110,121	TbpA	transferrin	7276	7018	Gene	Gene	receptor|appos|START_ENTITY components|nmod|receptor Cooperation|nmod|components Cooperation|nmod|uptake uptake|nmod|iron iron|compound|END_ENTITY	Cooperation between the components of the meningococcal transferrin receptor , TbpA and TbpB , in the uptake of transferrin iron by the 37-kDa ferric-binding protein -LRB- FbpA -RRB- .
9766237	0	TbpA	78,82	transferrin	56,67	TbpA	transferrin	7276	7018	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Cooperation between the components of the meningococcal transferrin receptor , TbpA and TbpB , in the uptake of transferrin iron by the 37-kDa ferric-binding protein -LRB- FbpA -RRB- .
10473127	0	Tbr2	26,30	Eomesodermin	32,44	Tbr2	Eomesodermin	13813(Tax:10090)	13813(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression pattern of the Tbr2 -LRB- Eomesodermin -RRB- gene during mouse and chick brain development .
20463296	0	Tbx1	21,25	Ash2l	0,5	Tbx1	Ash2l	6899	9070	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ash2l interacts with Tbx1 and is required during early embryogenesis .
21123999	0	Tbx1	30,34	Bmp4	16,20	Tbx1	Bmp4	6899	652	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling .
14975726	0	Tbx1	37,41	Fgf8	25,29	Tbx1	Fgf8	21380(Tax:10090)	14179(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse .
22367967	0	Tbx1	0,4	Mef2c	32,37	Tbx1	Mef2c	21380(Tax:10090)	17260(Tax:10090)	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|END_ENTITY	Tbx1 is a negative modulator of Mef2c .
20439995	0	Tbx1	0,4	Vegfr3	15,21	Tbx1	Vegfr3	6899	2324	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tbx1 regulates Vegfr3 and is required for lymphatic vessel development .
25142463	0	Tbx1	0,4	Wnt11r	81,87	Tbx1	Wnt11r	368206(Tax:7955)	30283(Tax:7955)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a .
24311985	0	Tbx1/10	16,23	NK4	0,3	Tbx1/10	NK4	6899;347853	9235	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	NK4 antagonizes Tbx1/10 to promote cardiac versus pharyngeal muscle fate in the ascidian second heart field .
17081734	0	Tbx16	0,5	Wnt11	22,27	Tbx16	Wnt11	30264(Tax:7955)	791595(Tax:7955)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer .
18644785	0	Tbx18	14,19	Pax3	58,62	Tbx18	Pax3	76365(Tax:10090)	18505(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	T-box protein Tbx18 interacts with the paired box protein Pax3 in the development of the paraxial mesoderm .
11087629	0	Tbx2	113,117	BMP2	95,99	Tbx2	BMP2	373990(Tax:9031)	378779(Tax:9031)	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Expression of chick Tbx-2 , Tbx-3 , and Tbx-5 genes during early heart development : evidence for BMP2 induction of Tbx2 .
9710594	0	Tbx2	39,43	TRP-1	86,91	Tbx2	TRP-1	6909	7306	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter .
14550786	0	Tbx20	21,26	Nkx2-5	51,57	Tbx20	Nkx2-5	57246(Tax:10090)	18091(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cardiac T-box factor Tbx20 directly interacts with Nkx2-5 , GATA4 , and GATA5 in regulation of gene expression in the developing heart .
21538160	0	Tbx3	14,18	Cx43	74,78	Tbx3	Cx43	556870(Tax:7955)	30236(Tax:7955)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43 .
18829543	0	Tbx3	0,4	E-cadherin	15,25	Tbx3	E-cadherin	6926	999	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Tbx3 represses E-cadherin expression and enhances melanoma_invasiveness .
23082988	0	Tbx3	0,4	PTEN	15,19	Tbx3	PTEN	6926	5728	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Tbx3 represses PTEN and is over-expressed in head and neck_squamous_cell_carcinoma .
24347445	0	Tbx4	0,4	Shox2	52,57	Tbx4	Shox2	21387(Tax:10090)	20429(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tbx4 interacts with the short stature homeobox gene Shox2 in limb development .
15923624	0	Tbx5	46,50	Connexin_40	0,11	Tbx5	Connexin 40	21388(Tax:10090)	14613(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Connexin_40 , a target of transcription factor Tbx5 , patterns wrist , digits , and sternum .
25725482	0	Tbx5	16,20	Fbxo25	0,6	Tbx5	Fbxo25	6910	26260	Gene	Gene	activity|amod|START_ENTITY controls|dobj|activity controls|nsubj|END_ENTITY	Fbxo25 controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development .
24565863	0	Tbx5	32,36	Histone_deacetylase_3	0,21	Tbx5	Histone deacetylase 3	21388(Tax:10090)	15183(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Histone_deacetylase_3 modulates Tbx5 activity to regulate early cardiogenesis .
11431700	0	Tbx5	0,4	Nkx2-5	21,27	Tbx5	Nkx2-5	21388(Tax:10090)	18091(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation .
19895804	0	Tbx5	28,32	Pdlim7	0,6	Tbx5	Pdlim7	30071(Tax:7955)	393813(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Pdlim7 -LRB- LMP4 -RRB- regulation of Tbx5 specifies zebrafish heart atrio-ventricular boundary and valve formation .
15986483	0	Tbx6	31,35	Dll1	0,4	Tbx6	Dll1	21389(Tax:10090)	13388(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Dll1 is a downstream target of Tbx6 in the paraxial mesoderm .
23326414	0	Tbx6	30,34	Hes7	11,15	Tbx6	Hes7	21389(Tax:10090)	84653(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Control of Hes7 expression by Tbx6 , the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock .
25641698	0	Tbx6	48,52	Mesp2	79,84	Tbx6	Mesp2	21389(Tax:10090)	17293(Tax:10090)	Gene	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2 .
19561075	0	Tbx6	47,51	Smad6	0,5	Tbx6	Smad6	6911	4091	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation .
2532601	0	TcR	61,64	CD3	22,25	TcR	TcR	328483(Tax:10090)	328483(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Surface expression of CD3 in the absence of T_cell_receptor -LRB- TcR -RRB- : evidence for sorting of partial TcR/CD3 complexes in a post-endoplasmic reticulum compartment .
2143170	0	TcR	40,43	CD4	89,92	TcR	CD4	6962	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|CD8 CD8|compound|END_ENTITY	Patterns of membrane TcR alpha beta and TcR gamma delta chain expression by normal blood CD4 + CD8 - , CD4-CD8 + , CD4-CD8dim + and CD4-CD8 - lymphocytes .
7737291	0	TcR	29,32	CD4	60,63	TcR	CD4	328483(Tax:10090)	12504(Tax:10090)	Gene	Gene	T_cell_receptor|appos|START_ENTITY T_cell_receptor|acl|targeting targeting|nmod|mice mice|acl|lacking lacking|dobj|END_ENTITY	Intrathymic T_cell_receptor -LRB- TcR -RRB- targeting in mice lacking CD4 or major histocompatibility complex -LRB- MHC -RRB- class II : rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II .
2143170	0	TcR	40,43	CD8	93,96	TcR	CD8	6962	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Patterns of membrane TcR alpha beta and TcR gamma delta chain expression by normal blood CD4 + CD8 - , CD4-CD8 + , CD4-CD8dim + and CD4-CD8 - lymphocytes .
1533311	0	TcR-alpha	48,57	CD4	38,41	TcR-alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY CD8|dep|cells Characterization|dep|CD8 Characterization|nmod|END_ENTITY	Characterization and function of CD3 + CD4 - CD8 - TcR-alpha beta bearing cells infiltrating the lung during the immune response .
8567401	0	TcR_alpha	53,62	CD4	70,73	TcR alpha	CD4	21473(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|appos|END_ENTITY	Frequent development of murine T-cell_lymphomas with TcR_alpha / beta + , CD4 - / 8 - phenotype after implantation of human inflammatory_breast_cancer cells in BALB/c nude_mice .
10575222	0	Tceb3	77,82	elongin_A	61,70	Tceb3	elongin A	27224(Tax:10090)	27224(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structural organization and chromosome location of the mouse elongin_A gene -LRB- Tceb3 -RRB- .
12944908	0	Tcf	144,147	beta-catenin	100,112	Tcf	beta-catenin	3172	1499	Gene	Gene	inhibition|nmod|START_ENTITY means|nmod|inhibition localization|dep|means localization|nmod|factor factor|nmod|END_ENTITY	Functional localization and competition between the androgen_receptor and T-cell factor for nuclear beta-catenin : a means for inhibition of the Tcf signaling axis .
15457508	0	Tcf	0,3	beta-catenin	45,57	Tcf	beta-catenin	3172	1499	Gene	Gene	sequence|compound|START_ENTITY determines|nsubj|sequence determines|dobj|responsiveness responsiveness|amod|END_ENTITY	Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters .
11711551	0	Tcf-4	27,32	beta-catenin	70,82	Tcf-4	beta-catenin	6925	1499	Gene	Gene	contains|nsubj|START_ENTITY contains|dobj|sites sites|nmod|END_ENTITY	The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin .
18519685	0	Tcf-4	34,39	claudin-7	10,19	Tcf-4	claudin-7	6925	1366	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal_cancer cells .
15018808	0	Tcf12	44,49	ME1	51,54	Tcf12	ME1	21406(Tax:10090)	17436(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the bHLH transcription factor Tcf12 -LRB- ME1 -RRB- gene is linked to the expansion of precursor cell populations during neurogenesis .
17405739	0	Tcf12	30,35	ME1	37,40	Tcf12	ME1	21406(Tax:10090)	17436(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	The bHLH transcription factor Tcf12 -LRB- ME1 -RRB- mRNA is abundantly expressed in Paneth cells of mouse intestine .
17878293	0	Tcf4	14,18	Math1	34,39	Tcf4	Math1	6925	474	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors .
12657632	0	Tcf4	13,17	beta-catenin	43,55	Tcf4	beta-catenin	6925	1499	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Hot spots in Tcf4 for the interaction with beta-catenin .
20890621	0	Tcf7	14,18	Runx2	22,27	Tcf7	Runx2	21414(Tax:10090)	12393(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation .
22065599	0	Tcl1	0,4	Atm	20,23	Tcl1	Atm	8115	472	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tcl1 interacts with Atm and enhances NF-kB activation in hematologic_malignancies .
26164272	0	Tcp-1	31,36	Gpd1	0,4	Tcp-1	Gpd1	851798(Tax:4932)	851539(Tax:4932)	Gene	Gene	Activity|nmod|START_ENTITY Regulates|dobj|Activity Regulates|nsubj|END_ENTITY	Gpd1 Regulates the Activity of Tcp-1 and Heat Shock Response in Yeast Cells : Effect on Aggregation of Mutant Huntingtin .
22150951	0	TcpC	24,28	VirB8	122,127	TcpC	VirB8	20469185	1224325(Tax:358)	Gene	Gene	related|nsubj|START_ENTITY related|nmod|END_ENTITY	The conjugation protein TcpC from Clostridium_perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria .
21700358	0	Tctex-1	11,18	DYNLT1	20,26	Tctex-1	DYNLT1	6993	6993	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for Tctex-1 -LRB- DYNLT1 -RRB- in controlling primary cilium length .
21262767	0	Tctex-1	0,7	Rab3D	40,45	Tctex-1	Rab3D	6993	9545	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Tctex-1 , a novel interaction partner of Rab3D , is required for osteoclastic bone resorption .
17342733	0	Tctex5	52,58	T-complex_testis_expressed_5	22,50	Tctex5	T-complex testis expressed 5	76497(Tax:10090)	76497(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of a novel T-complex_testis_expressed_5 -LRB- Tctex5 -RRB- in mouse testis , epididymis , and spermatozoa .
22481022	0	TdT	19,22	CD2	30,33	TdT	CD2	1791	914	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	Detection of CD34 , TdT , CD56 , CD2 , CD4 , and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically_normal_acute_myeloid_leukemia .
22481022	0	TdT	19,22	CD56	24,28	TdT	CD56	1791	4684	Gene	Gene	CD4|appos|START_ENTITY CD4|appos|END_ENTITY	Detection of CD34 , TdT , CD56 , CD2 , CD4 , and CD14 by flow cytometry is associated with NPM1 and FLT3 mutation status in cytogenetically_normal_acute_myeloid_leukemia .
1585413	0	TdT	71,74	Terminal_deoxynucleotidyl_Transferase	32,69	TdT	Terminal deoxynucleotidyl Transferase	294051(Tax:10116)	294051(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of Terminal_deoxynucleotidyl_Transferase -LRB- TdT -RRB- in rat thymocytes .
1249420	0	TdT	59,62	terminal_deoxynucleotidyl_transferase	20,57	TdT	terminal deoxynucleotidyl transferase	294051(Tax:10116)	294051(Tax:10116)	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- among subsets of thymocytes in the rat .
1473158	0	TdT	79,82	terminal_deoxynucleotidyl_transferase	40,77	TdT	terminal deoxynucleotidyl transferase	1791	1791	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunocytochemical study of recombinant terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- synthesized by baculovirus-infected insect cells .
16417922	0	TdT	61,64	terminal_deoxynucleotidyl_transferase	22,59	TdT	terminal deoxynucleotidyl transferase	1791	1791	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Evaluation of CD7 and terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- expression in CD34 + myeloblasts from patients with myelodysplastic_syndrome .
1841845	0	TdT	61,64	terminal_deoxynucleotidyl_transferase	22,59	TdT	terminal deoxynucleotidyl transferase	1791	1791	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Quantitative assay of terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- activity using monoclonal antibodies .
25999030	0	TdT	74,77	terminal_deoxynucleotidyl_transferase	35,72	TdT	terminal deoxynucleotidyl transferase	1791	1791	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	A luminescence switch-on probe for terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- activity detection by using an iridium -LRB- iii -RRB- - based i-motif probe .
291471	0	TdT	47,50	terminal_deoxynucleotidyl_transferase	8,45	TdT	terminal deoxynucleotidyl transferase	1791	1791	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Loss of terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- activity as a predictor of emergence of resistance to chemotherapy in a case of chronic_myelogenous_leukemia in blast_crisis .
8514336	0	TdT	98,101	terminal_deoxynucleotidyltransferase	60,96	TdT	terminal deoxynucleotidyltransferase	1791	1791	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Phorbol_ester-induced effects on cell cycle progression and terminal_deoxynucleotidyltransferase -LRB- TdT -RRB- activity in KM-3 pre-B cell line .
8217792	0	TdT	49,52	terminal_transferase	27,47	TdT	terminal transferase	1791	1791	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of terminal_transferase -LRB- TdT -RRB- in acute_lymphocytic_leukaemia expressing myeloid antigens and TdT positive acute_myeloid_leukaemia as compared to myeloid antigen negative acute_lymphocytic_leukaemia .
24069547	0	Tdgf1	17,22	Nkx2-5	0,6	Tdgf1	Nkx2-5	6997	1482	Gene	Gene	Regulates|xcomp|START_ENTITY Regulates|nsubj|END_ENTITY	Nkx2-5 Regulates Tdgf1 -LRB- Cripto -RRB- Early During Cardiac Development .
13679147	0	Tdp1	56,60	XRCC1	15,20	Tdp1	XRCC1	55775	7515	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of XRCC1 and tyrosyl_DNA_phosphodiesterase -LRB- Tdp1 -RRB- for the repair of topoisomerase I-mediated DNA lesions .
17576665	0	Tdp1	111,115	tyrosyl-DNA_phosphodiesterase	80,109	Tdp1	tyrosyl-DNA phosphodiesterase	55775	55775	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA_phosphodiesterase -LRB- Tdp1 -RRB- inhibitors and characterization of furamidine -LRB- NSC_305831 -RRB- as an inhibitor of Tdp1 .
14736747	0	Tead2	110,115	Pax3	134,138	Tead2	Pax3	21677(Tax:10090)	18505(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3 .
14736747	0	Tead2	110,115	Pax3	59,63	Tead2	Pax3	21677(Tax:10090)	18505(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3 .
21543328	0	Teashirt-3	0,10	BRG1-associated_factor_57	73,98	Teashirt-3	BRG1-associated factor 57	243931(Tax:10090)	57376(Tax:10090)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	Teashirt-3 , a novel regulator of muscle differentiation , associates with BRG1-associated_factor_57 -LRB- BAF57 -RRB- to inhibit myogenin gene expression .
12842985	0	Tec	0,3	GPVI	37,41	Tec	GPVI	7006	51206	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Tec regulates platelet activation by GPVI in the absence of Btk .
14993283	0	Tec	27,30	Tec	92,95	Tec	Bmx	7006	660	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Expression and function of Tec , Itk , and Btk in lymphocytes : evidence for a unique role for Tec .
14993283	0	Tec	92,95	Tec	27,30	Bmx	Tec	660	7006	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role Expression|dep|evidence Expression|nmod|END_ENTITY	Expression and function of Tec , Itk , and Btk in lymphocytes : evidence for a unique role for Tec .
19897738	0	Tec1	87,91	Cdc4	159,163	Tec1	Cdc4	852377(Tax:4932)	850539(Tax:4932)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Multisite phosphorylation of the Saccharomyces_cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo .
24732795	0	Tec1	26,30	Msa1	68,72	Tec1	Msa1	852377(Tax:4932)	854232(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development .
16953222	0	Tel-Abl	44,51	Hck	24,27	Tel-Abl	Hck	2120	15162(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The Src tyrosine kinase Hck is required for Tel-Abl - but not for Tel-Jak2-induced cell transformation .
24423165	0	Telomerase_Reverse_Transcriptase	25,57	TERT	64,68	Telomerase Reverse Transcriptase	TERT	403412(Tax:9615)	403412(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms within the Telomerase_Reverse_Transcriptase gene -LRB- TERT -RRB- in four breeds of dogs selected for difference in lifespan and cancer susceptibility .
20011463	0	Telomerase_Reverse_Transcriptase	28,60	hTERT	62,67	Telomerase Reverse Transcriptase	hTERT	7015	7015	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	In silico analysis of human Telomerase_Reverse_Transcriptase -LRB- hTERT -RRB- gene : identification of a distant homolog of Melanoma Antigen Family Gene -LRB- MAGE -RRB- .
25854384	0	Telomerase_Reverse_Transcriptase	30,62	hTERT	64,69	Telomerase Reverse Transcriptase	hTERT	7015	7015	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Prognostic Relevance of Human Telomerase_Reverse_Transcriptase -LRB- hTERT -RRB- Expression in Patients with Gall_Bladder_Disease_and_Carcinoma .
19331168	0	Telomerase_reverse_transcriptase	0,32	TERT	34,38	Telomerase reverse transcriptase	TERT	7015	7015	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Telomerase_reverse_transcriptase -LRB- TERT -RRB- expression in canine mammary tissues : a specific marker for malignancy ?
26376879	0	Ten-Eleven_Translocation_1	39,65	Aldolase_B	0,10	Ten-Eleven Translocation 1	Aldolase B	80312	229	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Aldolase_B inhibits metastasis through Ten-Eleven_Translocation_1 and serves as a prognostic biomarker in hepatocellular_carcinoma .
11230140	0	Ten1	0,4	Stn1	84,88	Ten1	Stn1	850696(Tax:4932)	851655(Tax:4932)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13 .
16157221	0	Tenascin-C	0,10	Akt	51,54	Tenascin-C	Akt	3371	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Tenascin-C promotes cell survival by activation of Akt in human chondrosarcoma cell .
22699754	0	Tenascin-C	0,10	Toll-like_receptor-4	97,117	Tenascin-C	Toll-like receptor-4	3371	7099	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	Tenascin-C produced by oxidized LDL-stimulated macrophages increases foam cell formation through Toll-like_receptor-4 .
7559800	0	Tenascin-C	0,10	epidermal_growth_factor	46,69	Tenascin-C	epidermal growth factor	3371	1950	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|END_ENTITY	Tenascin-C induction by the diffusible factor epidermal_growth_factor in stromal-epithelial interactions .
15001984	0	Tenascin-C	0,10	transforming_growth_factor-beta	27,58	Tenascin-C	transforming growth factor-beta	3371	7040	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Tenascin-C upregulation by transforming_growth_factor-beta in human dermal fibroblasts involves Smad3 , Sp1 , and Ets1 .
17311283	0	Tenascin_cytotactin	0,19	epidermal_growth_factor_receptor	62,94	Tenascin cytotactin	epidermal growth factor receptor	3371	1956	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Tenascin_cytotactin epidermal growth factor-like repeat binds epidermal_growth_factor_receptor with low affinity .
10341219	0	Teneurin-1	0,10	ten-m	68,73	Teneurin-1	ten-m	10178	40464(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Teneurin-1 , a vertebrate homologue of the Drosophila pair-rule gene ten-m , is a neuronal protein with a novel type of heparin-binding domain .
24344332	0	Teneurin-4	0,10	focal_adhesion_kinase	80,101	Teneurin-4	focal adhesion kinase	23966(Tax:10090)	14083(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal_adhesion_kinase signaling .
23233134	0	Tensin2	44,51	DISC1	15,20	Tensin2	DISC1	209039(Tax:10090)	244667(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of DISC1 with the PTB domain of Tensin2 .
20069572	0	Tensin_2	0,8	DLC1	77,81	Tensin 2	DLC1	23371	10395	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Tensin_2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1 .
15716051	0	Terminal_acidic_SANT_1	4,26	Tacs1	28,33	Terminal acidic SANT 1	Tacs1	542591(Tax:4577)	542591(Tax:4577)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Terminal_acidic_SANT_1 -LRB- Tacs1 -RRB- gene of maize is expressed in tissues containing meristems and encodes an acidic SANT domain similar to some chromatin-remodeling_complex_proteins .
1585413	0	Terminal_deoxynucleotidyl_Transferase	32,69	TdT	71,74	Terminal deoxynucleotidyl Transferase	TdT	294051(Tax:10116)	294051(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of Terminal_deoxynucleotidyl_Transferase -LRB- TdT -RRB- in rat thymocytes .
22740656	0	Terminal_deoxynucleotidyl_transferase	0,37	KU80	47,51	Terminal deoxynucleotidyl transferase	KU80	1791	7520	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Terminal_deoxynucleotidyl_transferase requires KU80 and XRCC4 to promote N-addition at non-V -LRB- D -RRB- J chromosomal breaks in non-lymphoid cells .
11554927	0	Terminal_deoxynucleotidyltransferase	0,36	proliferating_cell_nuclear_antigen	88,122	Terminal deoxynucleotidyltransferase	proliferating cell nuclear antigen	294051(Tax:10116)	25737(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Terminal_deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating_cell_nuclear_antigen .
25749352	0	Testis_Developmental_Related_Gene_1	31,66	TDRG1	68,73	Testis Developmental Related Gene 1	TDRG1	732253	732253	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and Localization of Testis_Developmental_Related_Gene_1 -LRB- TDRG1 -RRB- in Human Spermatozoa .
25305769	0	Testis_Specific_10	118,136	Tsga10	138,144	Testis Specific 10	Tsga10	211484(Tax:10090)	211484(Tax:10090)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Evaluation of in vitro Spermatogenesis System Effectiveness to Study Genes Behavior : Monitoring the Expression of the Testis_Specific_10 -LRB- Tsga10 -RRB- Gene as a Model .
11241784	0	Testis_brain_RNA-binding_protein	83,115	TB-RBP	117,123	Testis brain RNA-binding protein	TB-RBP	22099(Tax:10090)	22099(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Elevated levels of the polyadenylation factor CstF_64 enhance formation of the 1kB Testis_brain_RNA-binding_protein -LRB- TB-RBP -RRB- mRNA in male germ cells .
23254757	0	Tet2	54,58	Oct4	0,4	Tet2	Oct4	214133(Tax:10090)	100846986	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oct4 and the small molecule inhibitor , SC1 , regulates Tet2 expression in mouse embryonic stem cells .
26566124	0	Tetherin	24,32	BST-2	18,23	Tetherin	BST-2	69550(Tax:10090)	69550(Tax:10090)	Gene	Gene	Factor|nsubj|START_ENTITY END_ENTITY|parataxis|Factor	Endogenous Murine BST-2 / Tetherin Is Not a Major Restriction Factor of Influenza_A_Virus Infection .
27042298	0	Tetherin	18,26	BST-2	12,17	Tetherin	BST-2	684	684	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of BST-2 / Tetherin in host protection and disease manifestation .
23840623	0	Tetherin	33,41	BST2	27,31	Tetherin	BST2	684	684	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Aberrant regulation of the BST2 -LRB- Tetherin -RRB- promoter enhances cell proliferation and apoptosis evasion in high grade breast_cancer cells .
15682397	0	Tetraspanin-5	0,13	Tm4sf9	15,21	Tetraspanin-5	Tm4sf9	56224(Tax:10090)	56224(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tetraspanin-5 -LRB- Tm4sf9 -RRB- mRNA expression parallels neuronal maturation in the cerebellum of normal and L7En-2 transgenic_mice .
25637218	0	Tetraspanin_7	0,13	TSPAN7	15,21	Tetraspanin 7	TSPAN7	7102	7102	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tetraspanin_7 -LRB- TSPAN7 -RRB- expression is upregulated in multiple myeloma patients and inhibits_myeloma_tumour development in vivo .
26945392	0	Tetratricopeptide_Repeat_Domain_37	29,63	TTC37	65,70	Tetratricopeptide Repeat Domain 37	TTC37	9652	9652	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Identifying Mutations of the Tetratricopeptide_Repeat_Domain_37 -LRB- TTC37 -RRB- Gene in Infants With Intractable Diarrhea and a Comparison of Asian and Non-Asian Phenotype and Genotype : A Global Case-report Study of a Well-Defined Syndrome With Immunodeficiency .
7076068	0	Tf	13,15	Transferrin	0,11	Tf	Transferrin	7018	7018	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Transferrin -LRB- Tf -RRB- polymorphism : an analysis by isoelectric focusing .
21056642	0	Tf	26,28	transferrin	13,24	Tf	transferrin	22041(Tax:10090)	22041(Tax:10090)	Gene	Gene	Synthesis|appos|START_ENTITY Synthesis|nmod|END_ENTITY	Synthesis of transferrin -LRB- Tf -RRB- conjugated liposomes via Staudinger ligation .
3662433	0	Tf	29,31	transferrin	16,27	Tf	transferrin	7018	7018	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of transferrin -LRB- Tf -RRB- subtypes in several Mongoloid populations of East Asia .
15978747	0	Tfam	51,55	mitochondrial_transcription_factor_A	13,49	Tfam	mitochondrial transcription factor A	7019	7019	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Study of the mitochondrial_transcription_factor_A -LRB- Tfam -RRB- gene in the primate Presbytis cristata .
25989201	0	Tfam	56,60	mitochondrial_transcription_factor_A	18,54	Tfam	mitochondrial transcription factor A	7019	7019	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The regulation of mitochondrial_transcription_factor_A -LRB- Tfam -RRB- expression during skeletal muscle cell differentiation .
25989201	0	Tfam	56,60	mitochondrial_transcription_factor_A	18,54	Tfam	mitochondrial transcription factor A	7019	7019	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The regulation of mitochondrial_transcription_factor_A -LRB- Tfam -RRB- expression during skeletal muscle cell differentiation .
26182383	0	Tfam	56,60	mitochondrial_transcription_factor_A	18,54	Tfam	mitochondrial transcription factor A	7019	7019	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The regulation of mitochondrial_transcription_factor_A -LRB- Tfam -RRB- expression during skeletal muscle cell differentiation .
18630911	0	Tfb1	41,45	TFIIH	57,62	Tfb1	TFIIH	2965	2965	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	NMR structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of VP16 : structural similarities between VP16 and p53 .
19897425	0	Tfb2	28,32	TFIIH	52,57	Tfb2	TFIIH	855981(Tax:4932)	404672	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Interacting partners of the Tfb2 subunit from yeast TFIIH .
24155934	0	Tfr2	105,109	Hfe	73,76	Tfr2	Hfe	50765(Tax:10090)	15216(Tax:10090)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	In situ proximity ligation assays indicate that hemochromatosis proteins Hfe and transferrin_receptor_2 -LRB- Tfr2 -RRB- do not interact .
15075275	0	Tfs1p	0,5	Ira2p	49,54	Tfs1p	Ira2p	850875(Tax:4932)	854073(Tax:4932)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Tfs1p , a member of the PEBP family , inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces_cerevisiae .
15008249	0	Tg	148,150	RAP	108,111	Tg	RAP	24826(Tax:10116)	116565(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY RAP|nmod|pathway role|nmod|RAP evidence|nmod|role thyroglobulin|dep|evidence thyroglobulin|acl|secretion secretion|nmod|cells cells|acl|transfected transfected|nmod|receptor receptor|acl|associated associated|dobj|protein protein|appos|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
15008249	0	Tg	148,150	RAP	137,140	Tg	RAP	24826(Tax:10116)	116565(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
15008249	0	Tg	24,26	RAP	108,111	Tg	RAP	24826(Tax:10116)	116565(Tax:10116)	Gene	Gene	thyroglobulin|appos|START_ENTITY thyroglobulin|acl|secretion secretion|nmod|cells cells|acl|transfected transfected|nmod|receptor receptor|acl|associated associated|dobj|protein protein|appos|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
15008249	0	Tg	24,26	RAP	137,140	Tg	RAP	24826(Tax:10116)	116565(Tax:10116)	Gene	Gene	thyroglobulin|appos|START_ENTITY thyroglobulin|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
17495424	0	Tg	56,58	thyroglobulin	41,54	Tg	thyroglobulin	21819(Tax:10090)	21819(Tax:10090)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	TGF-beta-like transcriptional effects of thyroglobulin -LRB- Tg -RRB- in mouse mesangial cells .
3082636	0	Tg	44,46	thyroglobulin	29,42	Tg	thyroglobulin	7038	7038	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Critical evaluation of serum thyroglobulin -LRB- Tg -RRB- levels during thyroid hormone suppression therapy versus Tg levels after hormone withdrawal and total_body_scan : results in 291 patients with thyroid_cancer .
22072420	0	Tgf-b	24,29	MiR-200b	0,8	Tgf-b	MiR-200b	7040	406984	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	MiR-200b is involved in Tgf-b signaling to regulate mammalian palate development .
23850470	0	Tgf-b	80,85	Srebp1c	69,76	Tgf-b	Srebp1c	7040	6720	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Regulation of brown adipogenesis by the Tgf-b family : involvement of Srebp1c in Tgf-b - and Activin-induced inhibition of adipogenesis .
15016653	0	Tgf-beta1	44,53	CD25	90,94	Tgf-beta1	CD25	21803(Tax:10090)	16184(Tax:10090)	Gene	Gene	inflammation|nmod|START_ENTITY inflammation|nmod|suppression suppression|nmod|cells cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
15016653	0	Tgf-beta1	44,53	CD4	86,89	Tgf-beta1	CD4	21803(Tax:10090)	12504(Tax:10090)	Gene	Gene	inflammation|nmod|START_ENTITY inflammation|nmod|suppression suppression|nmod|cells cells|compound|END_ENTITY	CD28 disruption exacerbates inflammation in Tgf-beta1 - / - mice : in vivo suppression by CD4 + CD25 + regulatory T cells independent of autocrine TGF-beta1 .
19383262	0	Tgfb1	77,82	transforming_growth_factor_beta1	10,42	Tgfb1	transforming growth factor beta1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Exogenous transforming_growth_factor_beta1 replacement and fertility in male Tgfb1 null mutant mice .
12478370	0	Tgfbeta2	0,8	Tgfbeta3	13,21	Tgfbeta2	Tgfbeta3	21808(Tax:10090)	21809(Tax:10090)	Gene	Gene	START_ENTITY|dep|/ /|parataxis|END_ENTITY	Tgfbeta2 - / - Tgfbeta3 - / - double knockout mice display severe_midline_fusion_defects and early embryonic_lethality .
12478370	0	Tgfbeta3	13,21	Tgfbeta2	0,8	Tgfbeta3	Tgfbeta2	21809(Tax:10090)	21808(Tax:10090)	Gene	Gene	/|parataxis|START_ENTITY END_ENTITY|dep|/	Tgfbeta2 - / - Tgfbeta3 - / - double knockout mice display severe_midline_fusion_defects and early embryonic_lethality .
25088698	0	Tgif	31,35	TG-interacting_factor	8,29	Tgif	TG-interacting factor	7050	7050	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of TG-interacting_factor -LRB- Tgif -RRB- in lipid metabolism .
23609452	0	Th-inducing_POK	60,75	60-kDa_Tat-interactive_protein	0,30	Th-inducing POK	60-kDa Tat-interactive protein	51043	10524	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	60-kDa_Tat-interactive_protein -LRB- TIP60 -RRB- positively regulates Th-inducing_POK -LRB- ThPOK -RRB- - mediated repression of eomesodermin in human CD4 + T cells .
19293635	0	Th1	46,49	CCR4	31,35	Th1	CCR4	51497	1233	Gene	Gene	cells|amod|START_ENTITY enhances|nsubj|cells enhances|nsubj|addition addition|nmod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
23358848	0	Th1	146,149	CCR6	140,144	Th1	CCR6	51497	1235	Gene	Gene	subset|amod|START_ENTITY subset|compound|END_ENTITY	Memory_T cells in latent Mycobacterium_tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3 + CCR6 + Th1 subset .
17485453	0	Th1	67,70	CD154	18,23	Th1	CD154	57314(Tax:10090)	21947(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	In the absence of CD154 , administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma_mansoni .
15240714	0	Th1	88,91	CD25	0,4	Th1	CD25	57314(Tax:10090)	16184(Tax:10090)	Gene	Gene	development|amod|START_ENTITY suppressing|dobj|development Th2|advcl|suppressing contribute|xcomp|Th2 contribute|nsubj|cells cells|compound|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
16998360	0	Th1	88,91	CD25	15,19	Th1	CD25	51497	3559	Gene	Gene	immunity|amod|START_ENTITY depresses|dobj|immunity depresses|nsubj|activity activity|compound|END_ENTITY	Increased CD4 + CD25 + T regulatory cell activity in trauma patients depresses protective Th1 immunity .
17563757	0	Th1	69,72	CD25	22,26	Th1	CD25	57314(Tax:10090)	16184(Tax:10090)	Gene	Gene	immunity|amod|START_ENTITY underlie|dobj|immunity underlie|nsubj|Downregulation Downregulation|nmod|cells cells|compound|END_ENTITY	Downregulation of CD4 + CD25 + regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells .
20128236	0	Th1	62,65	CD25	4,8	Th1	CD25	57314(Tax:10090)	16184(Tax:10090)	Gene	Gene	response|amod|START_ENTITY development|nmod|response prevent|dobj|development +|ccomp|prevent +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium_yoelii infection in susceptible BALB/c mice .
23734780	0	Th1	117,120	CD25	38,42	Th1	CD25	57314(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY process|nmod|cells generate|nmod|process generate|dobj|population population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
10603388	0	Th1	22,25	CD4	15,18	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of CD4 -LRB- + -RRB- Th1 cells in systemic immunity protective against primary and secondary challenges with Trypanosoma_cruzi .
10725710	0	Th1	46,49	CD4	22,25	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	subset|amod|START_ENTITY +|nmod|subset +|nsubj|Polarization Polarization|nmod|END_ENTITY	Polarization of naive CD4 + T cells toward the Th1 subset by CTLA-4 costimulation .
10813277	0	Th1	12,15	CD4	45,48	Th1	CD4	51497	920	Gene	Gene	Analysis|nmod|START_ENTITY cytokines|nsubj|Analysis cytokines|xcomp|expressing expressing|dobj|+ +|compound|END_ENTITY	Analysis of Th1 and Th2 cytokines expressing CD4 + and CD8 + T cells in rheumatoid_arthritis by flow cytometry .
10886511	0	Th1	80,83	CD4	35,38	Th1	CD4	51497	920	Gene	Gene	profile|amod|START_ENTITY display|dobj|profile display|nsubj|clones clones|compound|END_ENTITY	Cutaneous_T_cell_lymphoma reactive CD4 + cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis .
11037819	0	Th1	24,27	CD4	48,51	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	efficacy|nmod|START_ENTITY efficacy|dep|+ +|compound|END_ENTITY	Therapeutic efficacy of Th1 and Th2 L-selectin -- CD4 + tumor-reactive T cells .
11091281	0	Th1	0,3	CD4	68,71	Th1	CD4	51497	920	Gene	Gene	pattern|amod|START_ENTITY expressed|nsubjpass|pattern expressed|nmod|+ +|compound|END_ENTITY	Th1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4 + and CD8 + T cells .
11123297	0	Th1	24,27	CD4	55,58	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells generated|nsubj|production generated|nmod|cells cells|compound|END_ENTITY	IFN-gamma production by Th1 cells generated from naive CD4 + T cells exposed to norepinephrine .
11134187	0	Th1	84,87	CD4	15,18	Th1	CD4	51497	920	Gene	Gene	START_ENTITY|nsubj|cells cells|compound|END_ENTITY	EBNA1-specific CD4 + T cells in healthy carriers of Epstein-Barr_virus are primarily Th1 in function .
11385621	0	Th1	121,124	CD4	23,26	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY required|nmod|cells T|ccomp|required T|nsubj|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11385621	0	Th1	121,124	CD4	39,42	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY required|nmod|cells T|ccomp|required T|nsubj|CD4 CD4|dep|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11564779	0	Th1	126,129	CD4	19,22	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY tolerized|nmod|responses mice|acl|tolerized obtained|nmod|mice obtained|nsubj|cells cells|nummod|END_ENTITY	TGF-beta-producing CD4 + mediastinal lymph node cells obtained from mice tracheally tolerized to ovalbumin -LRB- OVA -RRB- suppress both Th1 - and Th2-induced cutaneous inflammatory responses to OVA by different mechanisms .
12055209	0	Th1	151,154	CD4	146,149	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	T and B cell recovery in arthritis adoptively transferred to SCID mice : antigen-specific activation is required for restoration of autopathogenic CD4 + Th1 cells in a syngeneic system .
12365717	0	Th1	58,61	CD4	0,3	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytokines|amod|START_ENTITY releasing|dobj|cytokines cause|advcl|releasing lymphocytes|xcomp|cause lymphocytes|nsubj|T T|compound|END_ENTITY	CD4 T lymphocytes cause hepatocyte apoptosis by releasing Th1 cytokines in cellular immunological liver_injury .
12391214	0	Th1	98,101	CD4	16,19	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	function|amod|START_ENTITY development|nmod|function deficient|nmod|development deficient|nsubj|cells cells|compound|END_ENTITY	Murine neonatal CD4 + lymph node cells are highly deficient in the development of antigen-specific Th1 function in adoptive adult hosts .
12444170	0	Th1	28,31	CD4	62,65	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|Th2 Th2|acl:relcl|cell cell|compound|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12496424	0	Th1	71,74	CD4	0,3	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	differentiation|nmod|START_ENTITY suppress|dobj|differentiation +|ccomp|suppress +|nsubj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + regulatory T cells suppress differentiation and functions of Th1 and Th2 cells , Leishmania_major_infection , and colitis in mice .
12763522	0	Th1	32,35	CD4	0,3	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY enigma|nmod|cells memory|dep|enigma memory|compound|END_ENTITY	CD4 + cell memory : the enigma of Th1 cells .
12807487	0	Th1	148,151	CD4	119,122	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|amod|START_ENTITY Th2|nmod|response deviates|nmod|Th2 deviates|dobj|cells cells|nummod|END_ENTITY	Induction of interleukin-12 production in mouse macrophages by berberine , a benzodioxoloquinolizine_alkaloid , deviates CD4 + T cells from a Th2 to a Th1 response .
1345789	0	Th1	82,85	CD4	60,63	Th1	CD4	51497	920	Gene	Gene	ligation|nmod|START_ENTITY ligation|nmod|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Central role for TCR/CD3 ligation in the differentiation of CD4 + T cells toward A Th1 or Th2 functional phenotype .
1345823	0	Th1	0,3	CD4	54,57	Th1	CD4	51497	920	Gene	Gene	profiles|amod|START_ENTITY profiles|nmod|END_ENTITY	Th1 lymphokine production profiles of nickel-specific CD4 + T-lymphocyte clones from nickel contact allergic and non-allergic individuals .
1355013	0	Th1	19,22	CD4	33,36	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	subset|amod|START_ENTITY subset|nmod|cells cells|compound|END_ENTITY	Involvement of the Th1 subset of CD4 + T cells in acquired immunity to mouse_infection with Trypanosoma equiperdum .
1355502	0	Th1	29,32	CD4	25,28	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	clones|amod|START_ENTITY clones|nummod|END_ENTITY	The cytotoxic process of CD4 Th1 clones .
14607905	0	Th1	69,72	CD4	73,76	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY immunity|compound|END_ENTITY	CD8alpha + and CD11b + dendritic cell-restricted MHC class II controls Th1 CD4 + T cell immunity .
14634090	0	Th1	85,88	CD4	81,84	Th1	CD4	51497	920	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	MHC class II-peptide complexes in dendritic cell lipid microdomains initiate the CD4 Th1 phenotype .
15128911	0	Th1	40,43	CD4	35,38	Th1	CD4	51497	920	Gene	Gene	inflammation|compound|START_ENTITY inflammation|compound|END_ENTITY	Biliary_atresia is associated with CD4 + Th1 cell-mediated portal tract inflammation .
15150429	0	Th1	41,44	CD4	19,22	Th1	CD4	51497	920	Gene	Gene	pathway|amod|START_ENTITY +|nmod|pathway +|nsubj|entry entry|nmod|END_ENTITY	Increased entry of CD4 + T cells into the Th1 cytokine effector pathway during T-cell division following stimulation in Behcet 's _ disease .
15240714	0	Th1	88,91	CD4	5,8	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	development|amod|START_ENTITY suppressing|dobj|development Th2|advcl|suppressing contribute|xcomp|Th2 contribute|nsubj|cells cells|compound|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15271903	0	Th1	5,8	CD4	0,3	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + Th1 cells induced by dendritic cell-based immunotherapy in mice chronically infected with Leishmania amazonensis do not promote healing .
15556683	0	Th1	75,78	CD4	138,141	Th1	CD4	51497	920	Gene	Gene	START_ENTITY|nmod|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Endogenous IL-4 and IFN-gamma are essential for expression of Th2 , but not Th1 cytokine message during the early differentiation of human CD4 + T helper cells .
15778385	0	Th1	19,22	CD4	14,17	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Early role of CD4 + Th1 cells and antibodies in HER-2 adenovirus vaccine protection against autochthonous mammary carcinomas .
15789061	0	Th1	14,17	CD4	9,12	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	effect|amod|START_ENTITY effect|compound|END_ENTITY	Combined CD4 + Th1 effect and lymphotactin transgene expression enhance CD8 + Tc1 tumor localization and therapy .
15789359	0	Th1	29,32	CD4	33,36	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	HSV induces an early primary Th1 CD4 T cell response in neonatal mice , but reduced CTL activity at the time of the peak adult response .
15814278	0	Th1	122,125	CD4	16,19	Th1	CD4	51497	920	Gene	Gene	response|amod|START_ENTITY mediates|nsubj|response T|parataxis|mediates T|nsubj|Contribution Contribution|nmod|+ +|compound|END_ENTITY	Contribution of CD4 + and CD8 + T cells and interferon-gamma to the progress of chronic rejection of kidney allografts : the Th1 response mediates both acute and chronic rejection .
15885644	0	Th1	11,14	CD4	6,9	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY participate|nsubj|cells +|ccomp|participate +|nsubj|END_ENTITY	Armed CD4 + Th1 effector cells and activated macrophages participate in bile_duct_injury in murine biliary_atresia .
16272312	0	Th1	53,56	CD4	48,51	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Sphingosine_kinase_1 is a negative regulator of CD4 + Th1 cells .
16424184	0	Th1	83,86	CD4	24,27	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	ratio|nmod|START_ENTITY determines|dobj|ratio determines|nsubj|Responsiveness Responsiveness|nmod|cells cells|compound|END_ENTITY	Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation .
16725235	0	Th1	8,11	CD4	89,92	Th1	CD4	51497	920	Gene	Gene	vaccine|compound|START_ENTITY CLIP|nsubj|vaccine CLIP|ccomp|enhances enhances|xcomp|responses responses|nsubj|END_ENTITY	HCV-NS3 Th1 minigene vaccine based on invariant chain CLIP genetic substitution enhances CD4 -LRB- + -RRB- Th1 cell responses in vivo .
16725235	0	Th1	96,99	CD4	89,92	Th1	CD4	51497	920	Gene	Gene	responses|amod|START_ENTITY responses|nsubj|END_ENTITY	HCV-NS3 Th1 minigene vaccine based on invariant chain CLIP genetic substitution enhances CD4 -LRB- + -RRB- Th1 cell responses in vivo .
16729885	0	Th1	41,44	CD4	36,39	Th1	CD4	51497	920	Gene	Gene	inflammation|compound|START_ENTITY inflammation|compound|END_ENTITY	Production of IL-16 correlates with CD4 + Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple_sclerosis_lesions .
16730774	0	Th1	51,54	CD4	46,49	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	CD1d expression on hemopoietic cells promotes CD4 + Th1 response in coxsackievirus B3 induced myocarditis .
1680917	0	Th1	77,80	CD4	23,26	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY down-regulation|nmod|synthesis correlates|nmod|down-regulation correlates|nsubj|Production Production|nmod|lymphocytes lymphocytes|amod|IL-10 IL-10|nmod|T T|compound|END_ENTITY	Production of IL-10 by CD4 + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth_infection .
1682389	0	Th1	29,32	CD4	24,27	Th1	CD4	51497	920	Gene	Gene	clones|amod|START_ENTITY +|dobj|clones +|nsubj|cytotoxicity cytotoxicity|nmod|END_ENTITY	A novel cytotoxicity of CD4 + Th1 clones on heat-shocked_tumor targets .
16998360	0	Th1	88,91	CD4	10,13	Th1	CD4	51497	920	Gene	Gene	immunity|amod|START_ENTITY depresses|dobj|immunity depresses|nsubj|activity activity|compound|END_ENTITY	Increased CD4 + CD25 + T regulatory cell activity in trauma patients depresses protective Th1 immunity .
17081623	0	Th1	73,76	CD4	0,3	Th1	CD4	51497	920	Gene	Gene	markers|amod|START_ENTITY enriched|nmod|markers enriched|nsubjpass|cells cells|compound|END_ENTITY	CD4 -LRB- + -RRB- memory T cells with high CD26 surface expression are enriched for Th1 markers and correlate with clinical severity of multiple_sclerosis .
17135575	0	Th1	33,36	CD4	77,80	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	effector|nsubj|START_ENTITY effector|nmod|cells cells|compound|END_ENTITY	Prostaglandin_I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells .
17274112	0	Th1	5,8	CD4	0,3	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + Th1 cells promote CD8 + Tc1 cell survival , memory response , tumor localization and therapy by targeted delivery of interleukin_2 via acquired pMHC I complexes .
17563757	0	Th1	69,72	CD4	18,21	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	immunity|amod|START_ENTITY underlie|dobj|immunity underlie|nsubj|Downregulation Downregulation|nmod|cells cells|compound|END_ENTITY	Downregulation of CD4 + CD25 + regulatory T cells may underlie enhanced Th1 immunity caused by immunization with activated autologous T cells .
17805015	0	Th1	0,3	CD4	20,23	Th1	CD4	51497	920	Gene	Gene	polarization|amod|START_ENTITY polarization|nmod|+ +|compound|END_ENTITY	Th1 polarization of CD4 + T cells by Toll-like receptor 3-activated human microglia .
17881511	0	Th1	57,60	CD4	80,83	Th1	CD4	51497	920	Gene	Gene	differentiation|amod|START_ENTITY differentiation|nmod|cells cells|nummod|END_ENTITY	HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4 + T cells via suppression of dendritic cell IL-12 production .
18606658	0	Th1	95,98	CD4	0,3	Th1	CD4	51497	920	Gene	Gene	cytokines|amod|START_ENTITY synthesize|dobj|cytokines express|ccomp|synthesize transduced|xcomp|express cells|acl|transduced CD25|dep|cells CD25|compound|END_ENTITY	CD4 + CD25 - T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model .
19029829	0	Th1	107,110	CD4	13,16	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|amod|START_ENTITY induces|dobj|response induces|nsubj|Depletion Depletion|nmod|CD25 CD25|compound|END_ENTITY	Depletion of CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- regulatory T cells from tumor infiltrating lymphocytes predominantly induces Th1 type immune response in vivo which inhibits tumor growth in adoptive immunotherapy .
19293635	0	Th1	46,49	CD4	39,42	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
19564349	0	Th1	88,91	CD4	83,86	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY immunity|compound|END_ENTITY	Dendritic_cells require a systemic type I interferon response to mature and induce CD4 + Th1 immunity with poly IC as adjuvant .
19596772	0	Th1	48,51	CD4	43,46	Th1	CD4	51497	920	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	CT043 , a protective antigen that induces a CD4 + Th1 response during Chlamydia_trachomatis_infection in mice and humans .
19670379	0	Th1	254,257	CD4	73,76	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	involving|nmod|START_ENTITY reported|advcl|involving serves|ccomp|reported serves|nsubj|effects effects|nmod|IFN-beta IFN-beta|nmod|production production|nmod|osteopontin osteopontin|nmod|Cells Cells|compound|END_ENTITY	Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4 + T Cells in MS. IFN-beta currently serves as one of the major treatments for MS. Its anti-inflammatory mechanism has been reported as involving a shift in cytokine balance from Th1 to Th2 in the T-cell response against elements of the myelin sheath .
1972170	0	Th1	55,58	CD4	39,42	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|nmod|cells +|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of tumor-infiltrating CD4 + T cells as Th1 cells based on lymphokine secretion and functional properties .
19726768	0	Th1	112,115	CD4	108,111	Th1	CD4	51497	920	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tuberculosis-associated_immune_restoration_syndrome in HIV-1-infected patients involves tuberculin-specific CD4 Th1 cells and KIR-negative gammadelta T cells .
19781678	0	Th1	101,104	CD4	105,108	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4 + cells and strong antibody responses in mice .
20128236	0	Th1	62,65	CD4	0,3	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|amod|START_ENTITY development|nmod|response prevent|dobj|development +|ccomp|prevent +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	CD4 + CD25 + Foxp3 + regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of Plasmodium_yoelii infection in susceptible BALB/c mice .
20888363	0	Th1	45,48	CD4	102,105	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY stem|dobj|cells stem|nmod|state state|nmod|activation activation|compound|END_ENTITY	Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4 + T cell activation .
21172925	0	Th1	148,151	CD4	152,155	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Analysis of immune reconstitution after autologous CD34 + stem/progenitor cell transplantation for systemic sclerosis : predominant reconstitution of Th1 CD4 + T cells .
21270829	0	Th1	137,140	CD4	114,117	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	ve|nmod|START_ENTITY ve|dobj|cells cells|compound|END_ENTITY	Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of na ve CD4 T cells toward the Th1 , Th2 and Th17 lineages .
21600260	0	Th1	90,93	CD4	94,97	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|nummod|+ +|compound|END_ENTITY	Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4 + cells and strong mucosal and systemic antibody responses in mice .
21646911	0	Th1	83,86	CD4	37,40	Th1	CD4	51497	920	Gene	Gene	cytokines|amod|START_ENTITY reducing|dobj|cytokines response|advcl|reducing response|nsubj|END_ENTITY	HIV-1_infection impairs HSV-specific CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- T-cell response by reducing Th1 cytokines and CCR5 ligand secretion .
21655295	0	Th1	86,89	CD4	36,39	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	granulomatous_lung_inflammation|amod|START_ENTITY modulates|dobj|granulomatous_lung_inflammation modulates|nsubj|expression expression|nmod|cells cells|nummod|END_ENTITY	Dysregulated cytokine expression by CD4 + T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous_lung_inflammation .
21984703	0	Th1	70,73	CD4	27,30	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY cytokine|nsubj|independent develop|ccomp|cytokine develop|nsubj|cells cells|compound|END_ENTITY	Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis .
22302060	0	Th1	12,15	CD4	96,99	Th1	CD4	51497	920	Gene	Gene	production|amod|START_ENTITY drives|dobj|production drives|advcl|lacking lacking|nsubj|increase increase|nmod|cells cells|compound|END_ENTITY	IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Ra .
23064187	0	Th1	5,8	CD4	0,3	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + Th1 cells are effectors in lupus_nephritis -- but what are their targets ?
23630349	0	Th1	65,68	CD4	12,15	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY differentiation|nmod|cells regulates|dobj|differentiation regulates|nsubj|Location Location|nmod|priming priming|compound|END_ENTITY	Location of CD4 + T cell priming regulates the differentiation of Th1 and Th17 cells and their contribution to arthritis .
23715742	0	Th1	59,62	CD4	0,3	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	affects|dobj|START_ENTITY affects|nsubj|IL-2 IL-2|compound|END_ENTITY	CD4 T cell-intrinsic IL-2 signaling differentially affects Th1 and Th17 development .
23734780	0	Th1	117,120	CD4	34,37	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY process|nmod|cells generate|nmod|process generate|dobj|population population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
24197135	0	Th1	29,32	CD4	14,17	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|Regulation Regulation|nmod|NKG2D NKG2D|compound|END_ENTITY	Regulation of CD4 -LRB- + -RRB- NKG2D -LRB- + -RRB- Th1 cells in patients with metastatic_melanoma treated with sorafenib : role of IL-15Ra and NKG2D triggering .
24489707	0	Th1	56,59	CD4	40,43	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY modulate|nmod|cells modulate|dobj|polarization polarization|nmod|cells cells|compound|END_ENTITY	Astrocytes modulate the polarization of CD4 + T cells to Th1 cells .
24799699	0	Th1	56,59	CD4	52,55	Th1	CD4	51497	920	Gene	Gene	immunity|compound|START_ENTITY immunity|compound|END_ENTITY	Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral_infection .
25740946	0	Th1	99,102	CD4	46,49	Th1	CD4	51497	920	Gene	Gene	Cells|compound|START_ENTITY Origin|nmod|Cells Origin|compound|END_ENTITY	Demethylation of the RORC2 and IL17A in Human CD4 + T Lymphocytes Defines Th17 Origin of Nonclassic Th1 Cells .
26056253	0	Th1	56,59	CD4	77,80	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	Cavity|nmod|START_ENTITY Development|nmod|Cavity Memory|nsubj|Development Memory|dobj|Cells Cells|compound|END_ENTITY	Early Development in the Peritoneal Cavity of CD49dhigh Th1 Memory Phenotype CD4 + T Cells with Enhanced B Cell Helper Activity .
7495735	0	Th1	9,12	CD4	4,7	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY +|dep|cells +|compound|END_ENTITY	Are CD4 + Th1 cells pro-inflammatory or anti-inflammatory ?
7538051	0	Th1	15,18	CD4	40,43	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Enrichment|nmod|cells +|nsubj|Enrichment +|dobj|fraction fraction|compound|END_ENTITY	Enrichment for Th1 cells in the Mel-14 + CD4 + T cell fraction in aged mice .
7541726	0	Th1	62,65	CD4	57,60	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	clones|amod|START_ENTITY +|dobj|clones +|nsubj|mechanism mechanism|nmod|cytotoxicity cytotoxicity|nmod|END_ENTITY	The molecular mechanism of FasL-mediated cytotoxicity by CD4 + Th1 clones .
7561083	0	Th1	38,41	CD4	68,71	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	development|amod|START_ENTITY development|nmod|T T|compound|END_ENTITY	Opposing effects of TGF-beta_2 on the Th1 cell development of naive CD4 + T cells isolated from different mouse strains .
7600284	0	Th1	14,17	CD4	105,108	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY Inhibition|nmod|responses prevents|nsubj|Inhibition prevents|xcomp|inflammatory_bowel_disease inflammatory_bowel_disease|nmod|mice mice|acl|reconstituted reconstituted|nmod|cells cells|compound|END_ENTITY	Inhibition of Th1 responses prevents inflammatory_bowel_disease in scid mice reconstituted with CD45RBhi CD4 + T cells .
7699320	0	Th1	25,28	CD4	20,23	Th1	CD4	51497	12504(Tax:10090)	Gene	Gene	clones|amod|START_ENTITY mediate|nsubj|clones +|ccomp|mediate +|nsubj|END_ENTITY	Poliovirus-specific CD4 + Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic_mice expressing the human poliovirus receptor .
7730613	0	Th1	60,63	CD4	81,84	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY development|nmod|cells produce|dobj|development produce|nmod|cells cells|compound|END_ENTITY	Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4 + T cells .
7930573	0	Th1	67,70	CD4	32,35	Th1	CD4	51497	920	Gene	Gene	develop|nmod|START_ENTITY develop|nsubj|cell cell|compound|END_ENTITY	Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype .
8020550	0	Th1	0,3	CD4	12,15	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	specific|compound|START_ENTITY specific|compound|END_ENTITY	Th1 and Th2 CD4 + T cell clones specific for Plasmodium_chabaudi but not for an unrelated antigen protect against blood stage P. _ chabaudi infection .
8098671	0	Th1	59,62	CD4	14,17	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	dose|nmod|START_ENTITY responses|nmod|dose responses|amod|functional functional|nmod:npmod|+ +|nummod|END_ENTITY	Separation of CD4 + functional responses by peptide dose in Th1 and Th2 subsets expressing the same transgenic antigen receptor .
8100844	0	Th1	27,30	CD4	39,42	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nsubj|activation	Differential activation of Th1 and Th2 CD4 + cells by murine brain microvessel endothelial cells and smooth muscle/pericytes .
8260458	0	Th1	68,71	CD4	109,112	Th1	CD4	51497	920	Gene	Gene	production|amod|START_ENTITY production|nmod|CD8 CD8|compound|END_ENTITY	Function of alpha beta TCR + intestinal intraepithelial lymphocytes : Th1 - and Th2-type cytokine production by CD4 + CD8 - and CD4 + CD8 + T cells for helper activity .
8606068	0	Th1	19,22	CD4	14,17	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	Transfer of a CD4 + Th1 cell line to nude_mice effects clearance of Rhodococcus_equi from the lung .
8608641	0	Th1	9,12	CD4	49,52	Th1	CD4	51497	920	Gene	Gene	cytokine|nsubj|START_ENTITY cytokine|dobj|expression expression|nmod|END_ENTITY	Selected Th1 and Th2 cytokine mRNA expression by CD4 -LRB- + -RRB- T cells isolated from inflamed human gingival tissues .
8658054	0	Th1	32,35	CD4	27,30	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|Activation Activation|nmod|END_ENTITY	Activation of cloned human CD4 + Th1 and Th2 cells by blood dendritic cells .
8698378	0	Th1	47,50	CD4	91,94	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Expression of L-selectin -LRB- CD62L -RRB- discriminates Th1 - and Th2-like cytokine-producing memory CD4 + T cells .
8707335	0	Th1	89,92	CD4	62,65	Th1	CD4	51497	920	Gene	Gene	lost|nmod|START_ENTITY lost|nmod|maturation maturation|compound|END_ENTITY	CD31 -LRB- PECAM-1 -RRB- is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells .
8748254	0	Th1	32,35	CD4	41,44	Th1	CD4	51497	920	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Mycobacterium bovis BCG-induced Th1 type CD4 + suppressor T cells act by suppressing IL-2 production and IL-2_receptor expression .
8752903	0	Th1	0,3	CD4	25,28	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	development|amod|START_ENTITY development|nmod|cells cells|compound|END_ENTITY	Th1 development of naive CD4 + T cells is inhibited by co-activation with anti-CD4 monoclonal antibodies .
8977227	0	Th1	89,92	CD4	56,59	Th1	CD4	51497	920	Gene	Gene	responses|amod|START_ENTITY impaired|dobj|responses impaired|nsubj|Patients Patients|nmod|multidrug-resistant_tuberculosis multidrug-resistant_tuberculosis|nmod|counts counts|compound|END_ENTITY	Patients with multidrug-resistant_tuberculosis with low CD4 + T cell counts have impaired Th1 responses .
9095259	0	Th1	36,39	CD4	21,24	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|nmod|START_ENTITY T|nmod|direction direction|nmod|END_ENTITY	In vivo direction of CD4 T cells to Th1 and Th2-like patterns of cytokine synthesis .
9178644	0	Th1	0,3	CD4	4,7	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Th1 CD4 + cells adoptively transfer experimental hypersensitivity_pneumonitis .
9521080	0	Th1	51,54	CD4	46,49	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY mediates|nsubj|cells +|acl:relcl|mediates +|compound|END_ENTITY	A T cell activation antigen , Ly6C , induced on CD4 + Th1 cells mediates an inhibitory signal for secretion of IL-2 and proliferation in peripheral immune responses .
9579368	0	Th1	103,106	CD4	121,124	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	commitment|amod|START_ENTITY commitment|nmod|cells cells|compound|END_ENTITY	Cyclophosphamide given after active specific immunization augments antitumor immunity by modulation of Th1 commitment of CD4 + T cells .
9627004	0	Th1	0,3	CD4	31,34	Th1	CD4	51497	920	Gene	Gene	cytokines|amod|START_ENTITY cytokines|nmod|+ +|compound|END_ENTITY	Th1 - and Th2-like cytokines in CD4 + and CD8 + T cells in autism .
9680328	0	Th1	146,149	CD4	119,122	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|differentiation differentiation|nmod|T-cells T-cells|compound|END_ENTITY	Reprogramming the signalling requirement for AP-1 _ -LRB- activator_protein-1 -RRB- activation during differentiation of precursor CD4 + T-cells into effector Th1 and Th2 cells .
9780149	0	Th1	85,88	CD4	61,64	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	secreting|dobj|START_ENTITY effectors|acl|secreting effectors|nummod|END_ENTITY	High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines .
9806643	0	Th1	35,38	CD4	19,22	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|nummod|END_ENTITY	Differentiation of CD4 + T cells to Th1 cells requires MAP kinase JNK2 .
9818646	0	Th1	13,16	CD4	169,172	Th1	CD4	51497	920	Gene	Gene	activity|amod|START_ENTITY Reduction|nmod|activity humanized|nsubj|Reduction humanized|nmod|END_ENTITY	Reduction of Th1 cell activity in the peripheral circulation of patients with rheumatoid_arthritis after treatment with a non-depleting humanized monoclonal antibody to CD4 .
9831181	0	Th1	90,93	CD4	35,38	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY +|nmod|mice +|nsubj|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
9848681	0	Th1	134,137	CD4	129,132	Th1	CD4	51497	920	Gene	Gene	clones|compound|START_ENTITY clones|compound|END_ENTITY	Isolation of recombinant phage clones expressing mycobacterial T cell antigens by screening a recombinant DNA library with human CD4 + Th1 clones .
9889959	0	Th1	43,46	CD4	38,41	Th1	CD4	57314(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Anti-leishmania effector functions of CD4 + Th1 cells and early events instructing Th2 cell development and susceptibility to Leishmania_major in BALB/c mice .
10820273	0	Th1	33,36	CD40_ligand	0,11	Th1	CD40 ligand	51497	959	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	CD40_ligand -LRB- CD154 -RRB- enhances the Th1 and antibody responses to respiratory_syncytial_virus in the BALB/c mouse .
7537538	0	Th1	22,25	CD5	15,18	Th1	CD5	51497	921	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CD5 in Th1 and Th2 contact-mediated rescue of anti-mu and ionomycin induced growth inhibition in a B_cell_lymphoma .
21490618	0	Th1	33,36	CD70	0,4	Th1	CD70	51497	970	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses .
11167679	0	Th1	71,74	CD8	49,52	Th1	CD8	51497	925	Gene	Gene	T-helper|dep|START_ENTITY T-helper|compound|END_ENTITY	A rapid flow cytometric assay to detect CD4 + and CD8 + T-helper -LRB- Th -RRB- 0 , Th1 and Th2 cells in whole blood and its application to study cytokine levels in atopic_dermatitis before and after cyclosporin therapy .
15925989	0	Th1	54,57	CD8	83,86	Th1	CD8	51497	925	Gene	Gene	response|amod|START_ENTITY elicits|dobj|response loaded|ccomp|elicits +|ccomp|loaded +|nsubj|END_ENTITY	Tumor lysate and IL-18 loaded dendritic cells elicits Th1 response , tumor-specific CD8 + cytotoxic T cells in patients with malignant_glioma .
17576775	0	Th1	34,37	CD8	0,3	Th1	CD8	51497	925	Gene	Gene	induce|dobj|START_ENTITY END_ENTITY|parataxis|induce	CD8 - DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS .
21469104	0	Th1	27,30	CD8	6,9	Th1	CD8	51497	925	Gene	Gene	responses|amod|START_ENTITY drive|dobj|responses drive|nsubj|cells cells|compound|END_ENTITY	Human CD8 T cells drive Th1 responses through the differentiation of TNF/iNOS-producing dendritic cells .
22689880	0	Th1	39,42	CD8	16,19	Th1	CD8	51497	925	Gene	Gene	polycytokines|amod|START_ENTITY producing|dobj|polycytokines cells|acl|producing cells|compound|END_ENTITY	Human antitumor CD8 + T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognition .
25202922	0	Th1	74,77	CD8	151,154	Th1	CD8	51497	925	Gene	Gene	Associated|nmod|START_ENTITY Cytokines/Chemokines|dep|Associated Cytokines/Chemokines|nsubj|Homeostasis Homeostasis|nmod|Cells Cells|compound|END_ENTITY	HIV-1 Shedding From the Female Genital Tract is Associated With Increased Th1 Cytokines/Chemokines That Maintain Tissue Homeostasis and Proportions of CD8 + FOXP3 + T Cells .
8260458	0	Th1	68,71	CD8	113,116	Th1	CD8	51497	925	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Function of alpha beta TCR + intestinal intraepithelial lymphocytes : Th1 - and Th2-type cytokine production by CD4 + CD8 - and CD4 + CD8 + T cells for helper activity .
12597781	0	Th1	29,32	CD81	6,10	Th1	CD81	51497	975	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Human CD81 directly enhances Th1 and Th2 cell activation , but preferentially induces proliferation of Th2 cells upon long-term stimulation .
14607905	0	Th1	69,72	CD8alpha	0,8	Th1	CD8alpha	57314(Tax:10090)	12525(Tax:10090)	Gene	Gene	immunity|compound|START_ENTITY controls|dobj|immunity controls|nsubj|+ +|compound|END_ENTITY	CD8alpha + and CD11b + dendritic cell-restricted MHC class II controls Th1 CD4 + T cell immunity .
22633083	0	Th1	73,76	CXCL10	87,93	Th1	CXCL10	51497	3627	Gene	Gene	cytokines|nmod|START_ENTITY modulation|nmod|cytokines chemokine|nsubj|modulation chemokine|dobj|END_ENTITY	Variable modulation by cytokines and thiazolidinediones of the prototype Th1 chemokine CXCL10 in anaplastic_thyroid_cancer .
23312578	0	Th1	44,47	CXCL10	0,6	Th1	CXCL10	57314(Tax:10090)	15945(Tax:10090)	Gene	Gene	infiltration|amod|START_ENTITY induces|dobj|infiltration induces|nsubj|END_ENTITY	CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase .
26046061	0	Th1	16,19	CXCL10	30,36	Th1	CXCL10	51497	3627	Gene	Gene	role|nmod|START_ENTITY chemokine|nsubj|role chemokine|dobj|END_ENTITY	The role of the Th1 chemokine CXCL10 in vitiligo .
14657006	0	Th1	62,65	CXCR3	40,45	Th1	CXCR3	51497	2833	Gene	Gene	loop|amod|START_ENTITY loop|compound|END_ENTITY	Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop .
15668916	0	Th1	33,36	CXCR3	0,5	Th1	CXCR3	57314(Tax:10090)	12766(Tax:10090)	Gene	Gene	response|amod|START_ENTITY mount|dobj|response mount|nsubj|mice mice|compound|END_ENTITY	CXCR3 - / - mice mount an efficient Th1 response but fail to control Leishmania_major_infection .
19293635	0	Th1	46,49	CXCR3	22,27	Th1	CXCR3	51497	2833	Gene	Gene	cells|amod|START_ENTITY enhances|nsubj|cells enhances|nsubj|addition addition|nmod|CCR4 CCR4|compound|END_ENTITY	Selective addition of CXCR3 -LRB- + -RRB- CCR4 -LRB- - -RRB- CD4 -LRB- + -RRB- Th1 cells enhances generation of cytotoxic T cells by dendritic cells in vitro .
19734217	0	Th1	21,24	CXCR3	0,5	Th1	CXCR3	57314(Tax:10090)	12766(Tax:10090)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	CXCR3 mediates renal Th1 and Th17 immune response in murine lupus_nephritis .
21789162	0	Th1	56,59	CXCR3	49,54	Th1	CXCR3	57314(Tax:10090)	12766(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Peritoneal cavity is dominated by IFNy-secreting CXCR3 + Th1 cells .
23358848	0	Th1	146,149	CXCR3	134,139	Th1	CXCR3	51497	2833	Gene	Gene	subset|amod|START_ENTITY subset|compound|END_ENTITY	Memory_T cells in latent Mycobacterium_tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3 + CCR6 + Th1 subset .
18056360	0	Th1	55,58	CXC_chemokine_ligand_16	18,41	Th1	CXC chemokine ligand 16	57314(Tax:10090)	66102(Tax:10090)	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Critical role for CXC_chemokine_ligand_16 -LRB- SR-PSOX -RRB- in Th1 response mediated by NKT cells .
26694585	0	Th1	16,19	EBI3	0,4	Th1	EBI3	57314(Tax:10090)	50498(Tax:10090)	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	EBI3 suppresses Th1 , Th17 and Th2 immune responses after Trypanosoma_cruzi_infection and inhibits parasite replication by interfering with alternative macrophage activation .
25202922	0	Th1	74,77	FOXP3	155,160	Th1	FOXP3	51497	50943	Gene	Gene	Associated|nmod|START_ENTITY Cytokines/Chemokines|dep|Associated Cytokines/Chemokines|nsubj|Homeostasis Homeostasis|nmod|Cells Cells|compound|END_ENTITY	HIV-1 Shedding From the Female Genital Tract is Associated With Increased Th1 Cytokines/Chemokines That Maintain Tissue Homeostasis and Proportions of CD8 + FOXP3 + T Cells .
23734780	0	Th1	117,120	Foxp3	43,48	Th1	Foxp3	57314(Tax:10090)	20371(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY process|nmod|cells generate|nmod|process generate|dobj|population population|compound|END_ENTITY	Mesenchymal stem cells generate a CD4 + CD25 + Foxp3 + regulatory T cell population during the differentiation process of Th1 and Th17 cells .
9261181	0	Th1	66,69	GATA-3	21,27	Th1	GATA-3	57314(Tax:10090)	14462(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene .
19811405	0	Th1	42,45	Hsp70	11,16	Th1	Hsp70	57314(Tax:10090)	15511(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY induces|dobj|responses induces|nsubj|END_ENTITY	Autologous Hsp70 induces antigen specific Th1 immune responses in a murine T-cell_lymphoma .
8609382	0	Th1	65,68	IFN-gamma	29,38	Th1	IFN-gamma	57314(Tax:10090)	15978(Tax:10090)	Gene	Gene	lymphocytes|compound|START_ENTITY synthesis|nmod|lymphocytes synthesis|amod|END_ENTITY	Vitamin_A down-regulation of IFN-gamma synthesis in cloned mouse Th1 lymphocytes depends on the CD28 costimulatory pathway .
10723680	0	Th1	71,74	IL-10	19,24	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	response|amod|START_ENTITY regulation|nmod|response Chronic_colitis|dep|regulation Chronic_colitis|nmod|END_ENTITY	Chronic_colitis in IL-10 - / - mice : insufficient counter regulation of a Th1 response .
10754317	0	Th1	110,113	IL-10	26,31	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY enhances|nmod|induction enhances|nsubj|Suppression Suppression|nmod|expression expression|compound|END_ENTITY	Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction : potential for cellular vaccine development .
11591763	0	Th1	68,71	IL-10	43,48	Th1	IL-10	51497	3586	Gene	Gene	cells|amod|START_ENTITY secretion|nmod|cells secretion|compound|END_ENTITY	Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells .
11908705	0	Th1	0,3	IL-10	35,40	Th1	IL-10	51497	3586	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Th1 and Th2 cytokine modulation by IL-10 / IL-12 imbalance in autoimmune_haemolytic_anaemia -LRB- AIHA -RRB- .
11937584	0	Th1	69,72	IL-10	26,31	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	switch|nmod|START_ENTITY correlates|nmod|switch correlates|nsubj|induction induction|nmod|END_ENTITY	Preferential induction of IL-10 in APC correlates with a switch from Th1 to Th2 response following infection with a low pathogenic variant of Theiler 's _ virus .
11971021	0	Th1	198,201	IL-10	62,67	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	response|compound|START_ENTITY loop|nmod|response extracellular_signal-regulated_kinase|nmod|loop role|nmod|extracellular_signal-regulated_kinase Role|dep|role Role|nmod|kinases kinases|nmod|END_ENTITY	Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production : central role of extracellular_signal-regulated_kinase in the negative feedback loop of the CpG DNA-mediated Th1 response .
14635055	0	Th1	54,57	IL-10	83,88	Th1	IL-10	51497	3586	Gene	Gene	responses|amod|START_ENTITY suppresses|dobj|responses suppresses|advcl|stimulating stimulating|dobj|production production|compound|END_ENTITY	Hepatitis_C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes .
15162438	0	Th1	98,101	IL-10	37,42	Th1	IL-10	51497	3586	Gene	Gene	response|amod|START_ENTITY enhances|dobj|response enhances|nsubj|modulation modulation|nmod|END_ENTITY	Small interference RNA modulation of IL-10 in human monocyte-derived dendritic cells enhances the Th1 response .
15585882	0	Th1	83,86	IL-10	0,5	Th1	IL-10	51497	3586	Gene	Gene	cytokines|amod|START_ENTITY subset|nmod|cytokines induction|nmod|subset released|dobj|induction released|nsubj|END_ENTITY	IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells .
16014524	0	Th1	45,48	IL-10	31,36	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Differential regulation of the IL-10 gene in Th1 and Th2 T cells .
16751369	0	Th1	35,38	IL-10	111,116	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	immunity|amod|START_ENTITY regulates|dobj|immunity regulates|advcl|mediating mediating|advcl|signaling signaling|dobj|reactivation reactivation|compound|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
16751369	0	Th1	35,38	IL-10	61,66	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	immunity|amod|START_ENTITY regulates|dobj|immunity regulates|advcl|mediating mediating|dobj|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
1680917	0	Th1	77,80	IL-10	14,19	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY down-regulation|nmod|synthesis correlates|nmod|down-regulation correlates|nsubj|Production Production|nmod|lymphocytes lymphocytes|amod|END_ENTITY	Production of IL-10 by CD4 + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth_infection .
16917957	0	Th1	67,70	IL-10	32,37	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	sources|nmod|START_ENTITY sources|nmod|END_ENTITY	Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo .
19058879	0	Th1	0,3	IL-10	68,73	Th1	IL-10	51497	3586	Gene	Gene	responses|amod|START_ENTITY convert|nsubj|responses convert|nmod|responses responses|compound|END_ENTITY	Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer 's _ disease .
19941850	0	Th1	22,25	IL-10	60,65	Th1	IL-10	51497	3586	Gene	Gene	polarization|amod|START_ENTITY polarization|acl|influencing influencing|dobj|production production|compound|END_ENTITY	Cryptomerione induces Th1 cell polarization via influencing IL-10 production by cholera toxin-primed dendritic cells .
21061443	0	Th1	46,49	IL-10	14,19	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Lck regulates IL-10 expression in memory-like Th1 cells .
21531623	0	Th1	4,7	IL-10	50,55	Th1	IL-10	51497	3586	Gene	Gene	cycle|amod|START_ENTITY cycle|dep|control control|nmod|IFN-y IFN-y|nmod|switching switching|compound|END_ENTITY	The Th1 life cycle : molecular control of IFN-y to IL-10 switching .
21728174	0	Th1	62,65	IL-10	33,38	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY drives|nmod|cells drives|dobj|production production|compound|END_ENTITY	TGF-b signaling via Smad4 drives IL-10 production in effector Th1 cells and reduces T-cell trafficking in EAE .
22266280	0	Th1	62,65	IL-10	42,47	Th1	IL-10	51497	3586	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells .
23028054	7	Th1	1257,1260	IL-10	1210,1215	Th1	IL-18	51497	3606	Gene	Gene	cultures|amod|START_ENTITY expression|nmod|cultures expression|compound|END_ENTITY	Interestingly , E4BP4 gene expression and the percentage of E4BP4 -LRB- + -RRB- cells of the recently shown IL-10 transcriptional regulator E4BP4 correlated with IL-10 gene expression and protein secretion in Th1 cultures .
23828573	0	Th1	40,43	IL-10	29,34	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	ifn-y-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal_cord_injury .
24120849	0	Th1	67,70	IL-10	112,117	Th1	IL-10	51497	3586	Gene	Gene	analysis|nmod|START_ENTITY _|nsubj|analysis _|dobj|cytokines cytokines|appos|IL-4 IL-4|dep|END_ENTITY	Cloning and sequence analysis of Peromyscus yucatanicus -LRB- Rodentia -RRB- Th1 -LRB- IL-12p35 , IFN-y_and_TNF -RRB- _ and_Th2 -LRB- IL-4 , IL-10 and TGF-b -RRB- cytokines .
25225664	0	Th1	38,41	IL-10	14,19	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|blockade blockade|compound|END_ENTITY	Early or late IL-10 blockade enhances Th1 and th17 effector responses and promotes fungal clearance in mice with cryptococcal_lung_infection .
26417443	0	Th1	37,40	IL-10	84,89	Th1	IL-10	51497	3586	Gene	Gene	expansion|nmod|START_ENTITY mediated|dobj|expansion mediated|xcomp|expressing expressing|dobj|correlates correlates|compound|END_ENTITY	IL-27 and TGFb mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary_tuberculosis .
8419468	0	Th1	47,50	IL-10	6,11	Th1	IL-10	51497	3586	Gene	Gene	helper|appos|START_ENTITY produced|nmod|helper produced|nsubjpass|END_ENTITY	Human IL-10 is produced by both type 1 helper -LRB- Th1 -RRB- and type 2 helper -LRB- Th2 -RRB- T cell clones and inhibits their antigen-specific proliferation and cytokine production .
9834110	0	Th1	48,51	IL-10	0,5	Th1	IL-10	57314(Tax:10090)	16153(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY development|nmod|responses required|nmod|development required|nsubjpass|END_ENTITY	IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida_albicans infection .
23650613	0	Th1	119,122	IL-13Ra1	99,107	Th1	IL-13Ra1	57314(Tax:10090)	16164(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Developmental expression of IL-12Rb2 on murine naive neonatal T cells counters the upregulation of IL-13Ra1 on primary Th1 cells and balances immunity in the newborn .
16729885	0	Th1	41,44	IL-16	14,19	Th1	IL-16	51497	3603	Gene	Gene	inflammation|compound|START_ENTITY correlates|nmod|inflammation correlates|nsubj|Production Production|nmod|END_ENTITY	Production of IL-16 correlates with CD4 + Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple_sclerosis_lesions .
15373921	0	Th1	45,48	IL-18	17,22	Th1	IL-18	51497	3606	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus_nephritis .
15477227	0	Th1	52,55	IL-18	0,5	Th1	IL-18	51497	3606	Gene	Gene	cells|amod|START_ENTITY induces|dobj|cells induces|nsubj|END_ENTITY	IL-18 together with anti-CD3 antibody induces human Th1 cells to produce Th1 - and Th2-cytokines and IL-8 .
25025954	0	Th1	146,149	IL-1b	87,92	Th1	IL-1b	51497	3553	Gene	Gene	cytokines|amod|START_ENTITY Involvement|nmod|cytokines Involvement|nmod|cytokines cytokines|amod|END_ENTITY	Ex vivo PBMC cytokine profile in familial_Mediterranean_fever patients : Involvement of IL-1b , IL-1a and Th17-associated cytokines and decrease of Th1 and Th2 cytokines .
26641550	0	Th1	51,54	IL-1b	94,99	Th1	IL-1b	51497	3553	Gene	Gene	Production|compound|START_ENTITY Production|nmod|END_ENTITY	A2E Suppresses Regulatory Function of RPE Cells in Th1 Cell Differentiation Via Production of IL-1b and Inhibition of PGE2 .
15120651	0	Th1	9,12	IL-22	0,5	Th1	IL-22	51497	50616	Gene	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	IL-22 , a Th1 cytokine that targets the pancreas and select other peripheral tissues .
18178832	0	Th1	16,19	IL-27	0,5	Th1	IL-27	57314(Tax:10090)	246779(Tax:10090)	Gene	Gene	response|amod|START_ENTITY induces|dobj|response induces|nsubj|END_ENTITY	IL-27 induces a Th1 immune response and susceptibility to experimental arthritis .
24021664	0	Th1	83,86	IL-27p28	0,8	Th1	IL-27p28	51497	246778	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses .
10878379	0	Th1	52,55	IL-4	84,88	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Helicobacter_pylori-induced mucosal_inflammation is Th1 mediated and exacerbated in IL-4 , but not IFN-gamma , gene-deficient mice .
11160346	0	Th1	30,33	IL-4	0,4	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	model|amod|START_ENTITY exacerbates|nmod|model exacerbates|nsubj|END_ENTITY	IL-4 exacerbates disease in a Th1 cell transfer model of colitis .
12055229	0	Th1	21,24	IL-4	124,128	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	differentiation|amod|START_ENTITY Role|nmod|differentiation Role|parataxis|regulates regulates|nmod|preventing preventing|dobj|effects effects|nmod|END_ENTITY	Role of IFN-gamma in Th1 differentiation : IFN-gamma regulates IL-18R_alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression .
12244163	0	Th1	44,47	IL-4	8,12	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	correlates|nmod|START_ENTITY correlates|compound|END_ENTITY	Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity_pneumonitis in two inbred strains of mice .
12444170	0	Th1	28,31	IL-4	47,51	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|dep|Th2 Th2|appos|IFN-gamma IFN-gamma|dep|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
1401925	0	Th1	110,113	IL-4	0,4	Th1	IL-4	51497	3565	Gene	Gene	exert|nmod|START_ENTITY exert|nsubj|END_ENTITY	IL-4 and IFN -LRB- alpha and gamma -RRB- exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones .
15084272	0	Th1	60,63	IL-4	0,4	Th1	IL-4	51497	3565	Gene	Gene	cells|amod|START_ENTITY apoptosis|nmod|cells drive|dobj|apoptosis receptor|acl|drive utilizes|dobj|receptor utilizes|nsubj|END_ENTITY	IL-4 utilizes an alternative receptor to drive apoptosis of Th1 cells and skews neonatal immunity toward Th2 .
1534825	0	Th1	71,74	IL-4	0,4	Th1	IL-4	51497	3565	Gene	Gene	cells|amod|START_ENTITY plays|nmod|cells plays|nsubj|END_ENTITY	IL-4 plays a dominant role in the differential development of Tho into Th1 and Th2 cells .
17199110	0	Th1	135,138	IL-4	191,195	Th1	IL-4	51497	3565	Gene	Gene	cells|amod|START_ENTITY inhibition|nmod|cells selection|dep|inhibition effective|nsubj|selection effective|nmod|END_ENTITY	3D computation modelling of the influence of cytokine secretion on Th-cell development suggests that negative selection -LRB- inhibition of Th1 cells -RRB- is more effective than positive selection by IL-4 for Th2 cell dominance .
19752754	0	Th1	81,84	IL-4	0,4	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	trafficking|compound|START_ENTITY required|nmod|trafficking expression|acl:relcl|required suppresses|dobj|expression suppresses|nsubj|END_ENTITY	IL-4 suppresses very late antigen-4 expression which is required for therapeutic Th1 T-cell trafficking into tumors .
21572032	0	Th1	76,79	IL-4	30,34	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	response|amod|START_ENTITY inhibit|dobj|response inhibit|nsubj|cells cells|acl|producing producing|dobj|END_ENTITY	Invariant NKT cells producing IL-4 or IL-10 , but not IFN-gamma , inhibit the Th1 response in experimental autoimmune encephalomyelitis , whereas none of these cells inhibits the Th17 response .
22464042	0	Th1	94,97	IL-4	25,29	Th1	IL-4	51497	3565	Gene	Gene	diseases|amod|START_ENTITY incidence|nmod|diseases reason|nmod|incidence levels|dep|reason levels|compound|END_ENTITY	Possible different serum IL-4 levels across populations : a reason for dissimilar incidence of Th1 and Th2 diseases .
22504655	0	Th1	36,39	IL-4	97,101	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	development|amod|START_ENTITY pathway|nmod|development Identification|nmod|pathway induced|nsubj|Identification induced|nmod|END_ENTITY	Identification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGF-b .
24120849	0	Th1	67,70	IL-4	106,110	Th1	IL-4	51497	3565	Gene	Gene	analysis|nmod|START_ENTITY _|nsubj|analysis _|dobj|cytokines cytokines|appos|END_ENTITY	Cloning and sequence analysis of Peromyscus yucatanicus -LRB- Rodentia -RRB- Th1 -LRB- IL-12p35 , IFN-y_and_TNF -RRB- _ and_Th2 -LRB- IL-4 , IL-10 and TGF-b -RRB- cytokines .
7541410	0	Th1	167,170	IL-4	107,111	Th1	IL-4	51497	3565	Gene	Gene	clones|amod|START_ENTITY promotes|nmod|clones promotes|dobj|production production|compound|END_ENTITY	Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones .
8799723	0	Th1	96,99	IL-4	38,42	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	response|amod|START_ENTITY lack|nmod|response correlated|nmod|lack correlated|nsubjpass|Susceptibility Susceptibility|nmod|Leishmania_major Leishmania_major|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Susceptibility to Leishmania_major in IL-4 transgenic_mice is not correlated with the lack of a Th1 immune response .
9794401	0	Th1	67,70	IL-4	0,4	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	independent|amod|START_ENTITY pathway|nmod|independent favors|dobj|pathway favors|nsubj|END_ENTITY	IL-4 in combination with TGF-beta favors an alternative pathway of Th1 development independent of IL-12 .
9973471	0	Th1	41,44	IL-4	108,112	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	cross-regulation|nmod|START_ENTITY Evidence|nmod|cross-regulation Evidence|dep|effects effects|nmod|Th1 Th1|acl|induced induced|nmod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
9973471	0	Th1	93,96	IL-4	108,112	Th1	IL-4	57314(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
19050254	0	Th1	88,91	Ifng	70,74	Th1	Ifng	51497	3458	Gene	Gene	differentiation|amod|START_ENTITY drives|dobj|differentiation drives|nsubj|removal removal|nmod|complexes complexes|nmod|locus locus|compound|END_ENTITY	T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation .
20027288	0	Th1	76,79	Ifng	27,31	Th1	Ifng	57314(Tax:10090)	15978(Tax:10090)	Gene	Gene	response|amod|START_ENTITY part|nmod|response induces|nmod|part induces|dobj|GTPases GTPases|compound|END_ENTITY	Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic_asthma .
22685315	0	Th1	36,39	Ifng	17,21	Th1	Ifng	51497	3458	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells END_ENTITY|dobj|expression	Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function .
22851706	0	Th1	98,101	Ifng	90,94	Th1	Ifng	57314(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Cutting edge : influence of Tmevpg1 , a long intergenic noncoding RNA , on the expression of Ifng by Th1 cells .
25225667	0	Th1	18,21	Ifng	41,45	Th1	Ifng	51497	3458	Gene	Gene	Genomic|compound|START_ENTITY Regulation|nmod|Genomic Locus|nsubj|Regulation Locus|advcl|END_ENTITY	Regulation of the Th1 Genomic Locus from Ifng through Tmevpg1 by T-bet .
24022011	0	Th1	56,59	Intercellular_adhesion_molecule_1	0,33	Th1	Intercellular adhesion molecule 1	51497	3383	Gene	Gene	cells|amod|START_ENTITY migration|nmod|cells mediates|dobj|migration mediates|nsubj|END_ENTITY	Intercellular_adhesion_molecule_1 mediates migration of Th1 and Th17 cells across human retinal_vascular_endothelium .
18658050	0	Th1	20,23	Interferon-gamma	0,16	Th1	Interferon-gamma	57314(Tax:10090)	15978(Tax:10090)	Gene	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	Interferon-gamma , a Th1 cytokine , regulates fat inflammation : a role for adaptive immunity in obesity .
9582275	0	Th1	31,34	Interferon-gamma	0,16	Th1	Interferon-gamma	57314(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway .
11170988	0	Th1	32,35	Interleukin-18	14,28	Th1	Interleukin-18	51497	3606	Gene	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	Expression of Interleukin-18 , a Th1 cytokine , in human gastric mucosa is increased in Helicobacter_pylori_infection .
11244043	0	Th1	30,33	Interleukin-18	0,14	Th1	Interleukin-18	51497	3606	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Interleukin-18 regulates both Th1 and Th2 responses .
11312119	0	Th1	57,60	Interleukin-18	0,14	Th1	Interleukin-18	57314(Tax:10090)	16173(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY stimulates|dobj|responses cytokine|acl:relcl|stimulates cytokine|nsubj|END_ENTITY	Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu .
16135392	0	Th1	24,27	Interleukin-18	0,14	Th1	Interleukin-18	57314(Tax:10090)	16173(Tax:10090)	Gene	Gene	immunity|amod|START_ENTITY enhances|dobj|immunity enhances|nsubj|END_ENTITY	Interleukin-18 enhances Th1 immunity and tumor protection of a DNA vaccine .
24275602	0	Th1	28,31	Interleukin-18	0,14	Th1	Interleukin-18	51497	3606	Gene	Gene	cytokine|nsubj|START_ENTITY cytokine|advmod|END_ENTITY	Interleukin-18 , more than a Th1 cytokine .
21061443	0	Th1	46,49	Lck	0,3	Th1	Lck	57314(Tax:10090)	16818(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	Lck regulates IL-10 expression in memory-like Th1 cells .
16237095	0	Th1	51,54	Osteopontin	0,11	Th1	Osteopontin	57314(Tax:10090)	20750(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY development|nmod|responses required|nmod|development required|nsubjpass|END_ENTITY	Osteopontin is not required for the development of Th1 responses and viral immunity .
24816543	0	Th1	0,3	P30	31,34	Th1	P30	51497	201161	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Th1 and Th2 immune response to P30 and ROP18 peptides in human toxoplasmosis .
22731402	0	Th1	17,20	PDLIM2	0,6	Th1	PDLIM2	51497	64236	Gene	Gene	restricts|dobj|START_ENTITY restricts|nsubj|END_ENTITY	PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune_disease .
15880426	0	Th1	0,3	PPARgamma	39,48	Th1	PPARgamma	51497	5468	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary_biliary_cirrhosis .
26491197	0	Th1	88,91	Peroxisome_Proliferator-Activated_Receptor_a	13,57	Th1	Peroxisome Proliferator-Activated Receptor a	57314(Tax:10090)	19013(Tax:10090)	Gene	Gene	Immunity|compound|START_ENTITY Immunity|compound|END_ENTITY	Antagonizing Peroxisome_Proliferator-Activated_Receptor_a Activity Selectively Enhances Th1 Immunity in Male Mice .
26123499	0	Th1	41,44	STAT4	0,5	Th1	STAT4	57314(Tax:10090)	20849(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE .
17404274	0	Th1	27,30	Schnurri-2	0,10	Th1	Schnurri-2	57314(Tax:10090)	15273(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Schnurri-2 controls memory Th1 and Th2 cell numbers in vivo .
10986385	0	Th1	86,89	Signaling_lymphocytic_activation_molecule	0,41	Th1	Signaling lymphocytic activation molecule	51497	6504	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Signaling_lymphocytic_activation_molecule -LRB- SLAM -RRB- is differentially expressed in human Th1 and Th2 cells .
12171942	0	Th1	18,21	T-bet	0,5	Th1	T-bet	51497	30009	Gene	Gene	responses|compound|START_ENTITY responses|amod|END_ENTITY	T-bet and mucosal Th1 responses in the gastrointestinal tract .
12393030	0	Th1	112,115	TGF-beta	100,108	Th1	TGF-beta	51497	7040	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Th1 down-regulation at the single-lymphocyte level in HCV-related liver cirrhosis and the effect of TGF-beta on Th1 response : possible implications for the development of hepatoma .
19834969	0	Th1	52,55	TL1A	0,4	Th1	TL1A	51497	9966	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn 's _ disease .
10438342	0	Th1	65,68	Th2	0,3	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY converted|nmod|responses converted|nsubjpass|responses responses|amod|END_ENTITY	Th2 responses to inactivated influenza virus can Be converted to Th1 responses and facilitate recovery from heterosubtypic virus_infection .
10510367	0	Th1	104,107	Th2	58,61	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	development|amod|START_ENTITY regulation|nmod|development induction|dep|regulation induction|nmod|differentiation differentiation|amod|END_ENTITY	Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation : a feedback regulation of Th1 development .
10623798	0	Th1	155,158	Th2	14,17	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	depends|nmod|START_ENTITY depends|nsubj|Modulation Modulation|nmod|responses responses|amod|END_ENTITY	Modulation of Th2 responses by peptide analogues in a murine model of allergic_asthma : amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide .
10711700	0	Th1	0,3	Th2	11,14	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|responses responses|amod|END_ENTITY	Th1 versus Th2 immune responses in autoimmune lacrimal gland_disease in MRL/Mp mice .
11013010	0	Th1	96,99	Th2	103,106	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Down-regulation of interleukin-12 , interleukin-12R expression/activity mediates the switch from Th1 to Th2 granuloma response during murine Schistosomiasis mansoni .
11180117	0	Th1	95,98	Th2	102,105	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	switch|nmod|START_ENTITY cytotoxic|nmod|switch cytotoxic|nmod|phenotype phenotype|amod|END_ENTITY	Impaired development of HIV-1 gp160-specific CD8 -LRB- + -RRB- cytotoxic T cells by a delayed switch from Th1 to Th2 cytokine phenotype in mice with Helicobacter_pylori_infection .
11385621	0	Th1	121,124	Th2	109,112	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY required|nmod|cells required|nmod|generation generation|nmod|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11937584	0	Th1	69,72	Th2	76,79	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	switch|nmod|START_ENTITY correlates|nmod|switch correlates|nmod|response response|amod|END_ENTITY	Preferential induction of IL-10 in APC correlates with a switch from Th1 to Th2 response following infection with a low pathogenic variant of Theiler 's _ virus .
12034094	0	Th1	14,17	Th2	96,99	Th1	Th2	51497	15111(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|HIV-1 HIV-1|nmod|mice mice|nmod|END_ENTITY	Generation of Th1 immune responses to inactivated , gp120-depleted HIV-1 in mice with a dominant Th2 biased immune profile via immunostimulatory -LSB- correction of imunostimulatory -RSB- oligonucleotides -- relevance to AIDS vaccines in developing countries .
12807487	0	Th1	148,151	Th2	139,142	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Induction of interleukin-12 production in mouse macrophages by berberine , a benzodioxoloquinolizine_alkaloid , deviates CD4 + T cells from a Th2 to a Th1 response .
14507448	0	Th1	54,57	Th2	47,50	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	type|amod|START_ENTITY END_ENTITY|nmod|type	Skin scratching switches immune responses from Th2 to Th1 type in epicutaneously immunized mice .
15240714	0	Th1	88,91	Th2	30,33	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	development|amod|START_ENTITY suppressing|dobj|development END_ENTITY|advcl|suppressing	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15294955	0	Th1	101,104	Th2	17,20	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	stimuli|amod|START_ENTITY responsiveness|nmod|stimuli associated|nmod|responsiveness associated|nsubjpass|polarization polarization|amod|END_ENTITY	Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling .
15661889	0	Th1	36,39	Th2	61,64	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY ability|nmod|responses ability|acl|inhibit inhibit|dobj|development development|amod|END_ENTITY	Limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo .
15987859	0	Th1	112,115	Th2	85,88	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	development|amod|START_ENTITY suppression|nmod|development modulate|nmod|suppression modulate|dobj|balance balance|nmod|pole pole|amod|END_ENTITY	Dietary -LRB- n-3 -RRB- polyunsaturated_fatty_acids modulate murine Th1/Th2 balance toward the Th2 pole by suppression of Th1 development .
16488475	0	Th1	9,12	Th2	99,102	Th1	Th2	51497	15111(Tax:10090)	Gene	Gene	cytokine|nsubj|START_ENTITY cytokine|nmod|onset onset|nmod|brucellosis brucellosis|acl|followed followed|advcl|switching switching|nmod|END_ENTITY	Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease .
16820320	0	Th1	50,53	Th2	57,60	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	induce|dobj|START_ENTITY induce|xcomp|END_ENTITY	Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver_injury in mice .
17597024	0	Th1	84,87	Th2	57,60	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|amod|START_ENTITY converts|nmod|response converts|dobj|response response|amod|END_ENTITY	Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary_tumor-bearing mice .
17641467	0	Th1	9,12	Th2	34,37	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	suppressive|nmod|START_ENTITY suppressive|nsubj|END_ENTITY	In vitro Th1 cytokine-independent Th2 suppressive effects of bifidobacteria .
1824635	0	Th1	18,21	Th2	67,70	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	production|amod|START_ENTITY Downregulation|nmod|production accompanies|nsubj|Downregulation accompanies|dobj|induction induction|nmod|responses responses|amod|END_ENTITY	Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth , Schistosoma_mansoni .
18991278	0	Th1	64,67	Th2	26,29	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY cytokine|acl:relcl|induces cytokine|amod|END_ENTITY	Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function .
18991278	0	Th1	64,67	Th2	91,94	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY cytokine|acl:relcl|induces functions|nmod|cytokine apoptosis|nsubj|functions apoptosis|dobj|function function|amod|END_ENTITY	Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function .
19234162	0	Th1	128,131	Th2	28,31	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	lymphoproliferative_disorder|nmod|START_ENTITY afflicting|nmod|lymphoproliferative_disorder afflicting|nsubj|END_ENTITY	STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat -LRB- Y136F -RRB- mice into a lymphoproliferative_disorder involving Th1 and CD8 effector T cells .
19542428	0	Th1	39,42	Th2	102,105	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY differentiation|nmod|cells Role|nmod|differentiation Role|parataxis|enhances enhances|dobj|development development|nmod|effectors effectors|amod|END_ENTITY	Role of CD44 in the differentiation of Th1 and Th2 cells : CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin .
20187766	0	Th1	94,97	Th2	101,104	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	shifting|dobj|START_ENTITY shifting|nmod|profile profile|amod|END_ENTITY	All-trans_retinoic_acid ameliorates trinitrobenzene_sulfonic_acid-induced colitis by shifting Th1 to Th2 profile .
20598563	0	Th1	0,3	Th2	7,10	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|deviation deviation|amod|END_ENTITY	Th1 to Th2 immune deviation facilitates , but does not cause , islet allograft tolerance in mice .
21086717	0	Th1	30,33	Th2	36,39	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	SerpinB2 deficiency modulates Th1 Th2 responses after schistosome infection .
22815380	0	Th1	35,38	Th2	84,87	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	production|amod|START_ENTITY downregulation|nmod|production accompanies|nsubj|downregulation accompanies|dobj|induction induction|nmod|responses responses|amod|END_ENTITY	Pillars article : downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth , Schistosoma_mansoni .
24036270	0	Th1	44,47	Th2	51,54	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	A novel chronic stress-induced shift in the Th1 to Th2 response promotes colon_cancer growth .
24442435	0	Th1	115,118	Th2	122,125	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|shift shift|amod|END_ENTITY	Cleavage of the T cell protein tyrosine phosphatase by the hepatitis_C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy .
2531194	2	Th1	103,106	Th2	38,41	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	clones|amod|START_ENTITY inhibits|nmod|clones factor|acl:relcl|inhibits secrete|dobj|factor secrete|nsubj|clones clones|amod|END_ENTITY	Th2 clones secrete a factor that inhibits cytokine production by Th1 clones .
7594508	0	Th1	125,128	Th2	22,25	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY induced|nmod|cells experimental_autoimmune_encephalomyelitis|acl|induced suppressors|nmod|experimental_autoimmune_encephalomyelitis suppressors|nsubj|cells cells|compound|END_ENTITY	Neuroantigen-specific Th2 cells are inefficient suppressors of experimental_autoimmune_encephalomyelitis induced by effector Th1 cells .
8525508	0	Th1	35,38	Th2	20,23	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Expansion of memory Th2 cells over Th1 cells in neonatal primed mice .
8536362	0	Th1	54,57	Th2	60,63	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	switch|compound|START_ENTITY switch|compound|END_ENTITY	An immunosuppressive murine leukaemia virus induces a Th1 -- > Th2 switch and abrogates the IgM antibody response to sheep erythrocytes by suppressing the production of IL-2 .
8648216	0	Th1	102,105	Th2	115,118	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia_coli induces early Th1 and late Th2 cytokine expression in Peyer 's patches .
8752836	0	Th1	62,65	Th2	0,3	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY sphingosine|nmod|cells susceptible|xcomp|sphingosine susceptible|nsubj|cells cells|amod|END_ENTITY	Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity .
9098720	0	Th1	139,142	Th2	162,165	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	mycobacterial|appos|START_ENTITY mycobacterial|appos|END_ENTITY	Effect of slow release IL-12 and IL-10 on inflammation , local macrophage function and the regional lymphoid response during mycobacterial -LRB- Th1 -RRB- and schistosomal -LRB- Th2 -RRB- antigen-elicited pulmonary_granuloma formation .
9237797	0	Th1	167,170	Th2	174,177	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	switch|nmod|START_ENTITY associated|nmod|switch associated|nmod|cytokines cytokines|amod|END_ENTITY	Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines .
9558102	0	Th1	15,18	Th2	76,79	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	response|amod|START_ENTITY response|nmod|activation activation|nmod|response response|amod|END_ENTITY	Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis .
9600317	0	Th1	136,139	Th2	147,150	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|subsets subsets|amod|END_ENTITY	Blockade of B7-2 , not B7-1 , inhibits purified protein derivative-primed T-lymphocyte responses but fails to influence the proportion of Th1 versus Th2 subsets .
9682366	0	Th1	76,79	Th2	40,43	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	shifts|nmod|START_ENTITY mice|acl:relcl|shifts response|nmod|mice response|amod|END_ENTITY	HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth_hormone .
9797511	0	Th1	4,7	Th2	11,14	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|shift shift|amod|END_ENTITY	The Th1 to Th2 shift induced by Schistosoma_mansoni does not exacerbate murine_aids -LRB- MAIDS -RRB- .
9916129	0	Th1	18,21	Th2	51,54	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY fail|nsubj|cells fail|xcomp|counterbalance counterbalance|dobj|airway_hyperreactivity airway_hyperreactivity|amod|END_ENTITY	Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway_hyperreactivity but cause severe airway_inflammation .
9973471	0	Th1	41,44	Th2	48,51	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
9973471	0	Th1	93,96	Th2	48,51	Th1	Th2	57314(Tax:10090)	15111(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY Evidence|dep|effects Evidence|nmod|cross-regulation cross-regulation|nmod|Th1 Th1|nmod|cells cells|amod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
23555662	0	Th1	71,74	Tissue_inhibitor_of_metalloproteinase_1	0,39	Th1	Tissue inhibitor of metalloproteinase 1	51497	7076	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Tissue_inhibitor_of_metalloproteinase_1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene .
16086788	0	Th1	34,37	Transforming_growth_factor-beta1	0,32	Th1	Transforming growth factor-beta1	57314(Tax:10090)	21803(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY END_ENTITY|appos|responses	Transforming_growth_factor-beta1 , Th1 responses , and autoimmune_liver_disease .
9682366	0	Th1	76,79	growth_hormone	105,119	Th1	growth hormone	57314(Tax:10090)	2688	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth_hormone .
14734605	0	Th1	64,67	inducible_co-stimulator	9,32	Th1	inducible co-stimulator	57314(Tax:10090)	54167(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Blocking inducible_co-stimulator in the absence of CD28 impairs Th1 and CD25 + regulatory T cells in murine colitis .
11801630	0	Th1	60,63	inducible_costimulator_protein	14,44	Th1	inducible costimulator protein	57314(Tax:10090)	54167(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	Cutting edge : inducible_costimulator_protein regulates both Th1 and Th2 responses to cutaneous_leishmaniasis .
11897670	0	Th1	27,30	interferon-gamma	34,50	Th1	interferon-gamma	57314(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Immune deviation away from Th1 in interferon-gamma knockout mice does not enhance TSH_receptor antibody production after naked DNA vaccination .
12048347	0	Th1	58,61	interleukin-18	22,36	Th1	interleukin-18	57314(Tax:10090)	16173(Tax:10090)	Gene	Gene	response|amod|START_ENTITY induces|dobj|response induces|nsubj|END_ENTITY	High-dose recombinant interleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma .
16367932	0	Th1	54,57	interleukin-18	9,23	Th1	interleukin-18	57314(Tax:10090)	16173(Tax:10090)	Gene	Gene	promote|dobj|START_ENTITY promote|nsubj|injections injections|amod|END_ENTITY	Multiple interleukin-18 injections promote both mouse Th1 and Th2 responses after sublethal Escherichia_coli infection .
19954659	0	Th1	71,74	interleukin-18	13,27	Th1	interleukin-18	51497	3606	Gene	Gene	response|amod|START_ENTITY receptor|nmod|response receptor|amod|END_ENTITY	-LSB- The role of interleukin-18 and interleukin-18 receptor in predominant Th1 immune response of patients with immune_thrombocytopenia -RSB- .
17274112	0	Th1	5,8	interleukin_2	119,132	Th1	interleukin 2	57314(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY promote|nsubj|cells promote|nmod|delivery delivery|nmod|END_ENTITY	CD4 + Th1 cells promote CD8 + Tc1 cell survival , memory response , tumor localization and therapy by targeted delivery of interleukin_2 via acquired pMHC I complexes .
20004699	0	Th1	11,14	leukotriene_B4_receptor_1	71,96	Th1	leukotriene B4 receptor 1	57314(Tax:10090)	16995(Tax:10090)	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|END_ENTITY	Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene_B4_receptor_1 .
18209488	0	Th1	88,91	thioredoxin	104,115	Th1	thioredoxin	51497	7295	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Induction of IFN-gamma gene expression by thioredoxin : positive feed-back regulation of Th1 response by thioredoxin and IFN-gamma .
23053511	0	Th2	18,21	Bcl6	0,4	Th2	Bcl6	15111(Tax:10090)	12053(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY controls|dobj|activity controls|nsubj|END_ENTITY	Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function .
9670926	0	Th2	59,62	CCR8	23,27	Th2	CCR8	15111(Tax:10090)	1237	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells .
15240714	0	Th2	30,33	CD25	0,4	Th2	CD25	15111(Tax:10090)	16184(Tax:10090)	Gene	Gene	contribute|xcomp|START_ENTITY contribute|nsubj|cells cells|compound|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
10598017	0	Th2	85,88	CD4	24,27	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytokines|nsubj|START_ENTITY produce|ccomp|cytokines produce|advcl|produce produce|nsubj|cells cells|nummod|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
10598017	0	Th2	85,88	CD4	66,69	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytokines|nsubj|START_ENTITY produce|ccomp|cytokines produce|nsubj|cells cells|compound|END_ENTITY	Antigen-stimulated lung CD4 + cells produce IL-5 , while lymph node CD4 + cells produce Th2 cytokines concomitant with airway eosinophilia and hyperresponsiveness .
10706693	0	Th2	147,150	CD4	123,126	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	profile|amod|START_ENTITY required|nmod|profile required|nmod|development development|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4 + lymphocytes with a Th2 cytokine profile .
10859331	0	Th2	221,224	CD4	151,154	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	Th1|nmod|START_ENTITY Alteration|nsubj|Th1 Alteration|dep|changes changes|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Alteration at a single amino_acid residue in the T_cell_receptor_alpha_chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 -LRB- Th1 -RRB- to Th2 .
10940889	0	Th2	66,69	CD4	144,147	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induce|nmod|induction induce|dep|expression expression|nmod|cells cells|compound|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
10946291	0	Th2	76,79	CD4	71,74	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	An immunomodulatory function for neutrophils during the induction of a CD4 + Th2 response in BALB/c mice infected with Leishmania_major .
11034364	0	Th2	74,77	CD4	20,23	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	differentiation|amod|START_ENTITY provide|nmod|differentiation provide|nsubj|cells cells|amod|naive naive|dep|END_ENTITY	Conventional , naive CD4 + T cells provide an initial source of IL-4 during Th2 differentiation .
11093173	0	Th2	81,84	CD4	63,66	Th2	CD4	15111(Tax:10090)	920	Gene	Gene	cells|amod|START_ENTITY cells|amod|cutaneous_lymphocyte-associated_antigen cutaneous_lymphocyte-associated_antigen|nmod|END_ENTITY	Expression of cutaneous_lymphocyte-associated_antigen on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- Th2 cells .
11385621	0	Th2	109,112	CD4	23,26	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	generation|nmod|START_ENTITY required|nmod|generation T|ccomp|required T|nsubj|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11385621	0	Th2	109,112	CD4	39,42	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	generation|nmod|START_ENTITY required|nmod|generation T|ccomp|required T|nsubj|CD4 CD4|dep|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11588111	0	Th2	131,134	CD4	96,99	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY Th1|nmod|pathway T|nmod|Th1 T|nsubj|END_ENTITY	Inhibition of interleukin-12 production by auranofin , an anti-rheumatic gold compound , deviates CD4 -LRB- + -RRB- T cells from the Th1 to the Th2 pathway .
11673504	0	Th2	104,107	CD4	59,62	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY development|nmod|cells enhance|dobj|development effect|acl|enhance effect|nmod|T T|compound|END_ENTITY	1alpha,25-Dihydroxyvitamin _ d3 has a direct effect on naive CD4 -LRB- + -RRB- T cells to enhance the development of Th2 cells .
11801634	0	Th2	38,41	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	conditions|amod|START_ENTITY selected|nmod|conditions cells|acl|selected cells|compound|END_ENTITY	CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3 .
11981831	0	Th2	87,90	CD4	36,39	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	differentiation|amod|START_ENTITY induce|dobj|differentiation secreted|xcomp|induce secreted|nmod|acts acts|compound|END_ENTITY	IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation .
12165514	0	Th2	33,36	CD4	111,114	Th2	CD4	15111(Tax:10090)	920	Gene	Gene	changes|nmod|START_ENTITY cytokine|nsubj|changes hypersensitive|dep|cytokine hypersensitive|nmod|T T|compound|END_ENTITY	DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4 -LRB- + -RRB- T cell differentiation .
12207329	0	Th2	44,47	CD4	31,34	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|distribution distribution|nmod|T1/ST2 T1/ST2|compound|END_ENTITY	Organ-specific distribution of CD4 + T1/ST2 + Th2 cells in Leishmania_major_infection .
12444170	0	Th2	32,35	CD4	62,65	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|cell cell|compound|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12538670	0	Th2	69,72	CD4	81,84	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	bias|amod|START_ENTITY bias|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Deregulated MHC_class_II transactivator expression leads to a strong Th2 bias in CD4 + T lymphocytes .
12807487	0	Th2	139,142	CD4	119,122	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	deviates|nmod|START_ENTITY deviates|dobj|cells cells|nummod|END_ENTITY	Induction of interleukin-12 production in mouse macrophages by berberine , a benzodioxoloquinolizine_alkaloid , deviates CD4 + T cells from a Th2 to a Th1 response .
12835475	0	Th2	91,94	CD4	69,72	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	lineage|amod|START_ENTITY inhibits|nmod|lineage inhibits|dobj|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	The Runx1 transcription factor inhibits the differentiation of naive CD4 + T cells into the Th2 lineage by repressing GATA3 expression .
1347553	0	Th2	5,8	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	CD4 + Th2 response induced by Schistosoma_mansoni eggs develops rapidly , through an early , transient , Th0-like stage .
14991598	0	Th2	76,79	CD4	92,95	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY acquisition|nmod|activity Pinpointing|dobj|acquisition Pinpointing|nmod|cells cells|compound|END_ENTITY	Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells .
15004191	0	Th2	78,81	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	phenotype|amod|START_ENTITY modulating|dobj|phenotype regulate|advcl|modulating +|ccomp|regulate +|nsubj|CD25 CD25|compound|END_ENTITY	CD4 + CD25 + T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype .
15240714	0	Th2	30,33	CD4	5,8	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	contribute|xcomp|START_ENTITY contribute|nsubj|cells cells|compound|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15388256	0	Th2	44,47	CD4	124,127	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|infection infection|acl|characterized characterized|nmod|increase increase|nmod|+ +|compound|END_ENTITY	The absence of IFN-gamma leads to increased Th2 responses after influenza_A_virus infection characterized by an increase in CD4 + but not CD8 + T cells producing IL-4 or IL-5 in the lung .
15714582	0	Th2	111,114	CD4	28,31	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|amod|START_ENTITY associated|nmod|response associated|nsubjpass|rejection rejection|acl|mediated mediated|nmod|cells cells|nummod|END_ENTITY	Graft rejection mediated by CD4 + T cells via indirect recognition of alloantigen is associated with a dominant Th2 response .
15876426	0	Th2	64,67	CD4	41,44	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytokines|amod|START_ENTITY produce|dobj|cytokines directs|xcomp|produce directs|dobj|cells cells|compound|END_ENTITY	Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus .
17312108	0	Th2	48,51	CD4	16,19	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	function|amod|START_ENTITY poised|nmod|function poised|nsubjpass|cells cells|nummod|END_ENTITY	Murine neonatal CD4 + cells are poised for rapid Th2 effector-like function .
17785819	0	Th2	82,85	CD4	42,45	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|amod|START_ENTITY effector|nmod|response effector|nsubj|role role|nmod|cells cells|nmod|development development|nmod|END_ENTITY	The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response .
18836070	0	Th2	74,77	CD4	117,120	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cytokines|amod|START_ENTITY production|nmod|cytokines production|nmod|cells cells|compound|END_ENTITY	Interferon_regulatory_factor_4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4 + T cells .
19264621	0	Th2	44,47	CD4	39,42	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Japanese_encephalitis_virus produces a CD4 + Th2 response and associated immunoprotection in an adoptive-transfer murine model .
21469117	0	Th2	60,63	CD4	42,45	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Selective effects of NF-kB1 deficiency in CD4 T cells on Th2 and TFh induction by alum-precipitated protein vaccines .
22424785	0	Th2	5,8	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 + Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene .
23047087	0	Th2	94,97	CD4	71,74	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	differentiating|nmod|START_ENTITY differentiating|dobj|cells cells|compound|END_ENTITY	Two distinct epitopes on the ovalbumin 323-339 peptide differentiating CD4 T cells into the Th2 or Th1 phenotype .
23052013	0	Th2	31,34	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Lymphocytes|appos|cells Lymphocytes|compound|END_ENTITY	CD4 + T Lymphocytes , especially Th2 cells , contribute to the progress of renal_fibrosis .
24769377	0	Th2	74,77	CD4	108,111	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	Th17|compound|START_ENTITY model|nmod|Th17 Lactobacillus_rhamnosus|nmod|model Effects|nmod|Lactobacillus_rhamnosus Effects|nmod|Foxp3 Foxp3|amod|END_ENTITY	Effects of Lactobacillus_rhamnosus on allergic march model by suppressing Th2 , Th17 , and TSLP responses via CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- + -RRB- Tregs .
7743677	0	Th2	44,47	CD4	75,78	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY MHC-specific|dobj|cells MHC-specific|nmod|generation generation|nmod|cells cells|compound|END_ENTITY	The influence of allo-class II MHC-specific Th2 cells on the generation of CD4 and CD8 cytotoxic T cells to associated class I and class II MHC alloantigen .
7908325	0	Th2	35,38	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY +|nmod|pathway +|nsubj|END_ENTITY	CD4 + effector cells default to the Th2 pathway in interferon_gamma-deficient mice infected with Leishmania_major .
8525520	0	Th2	4,7	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD4 Th2 cells do not functionally suppress CTL generation in neonatal tolerant mice .
8613355	0	Th2	128,131	CD4	123,126	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
9043951	0	Th2	15,18	CD4	35,38	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	polarization|amod|START_ENTITY polarization|nmod|response response|compound|END_ENTITY	Lack of Th1 or Th2 polarization of CD4 + T cell response induced by particulate antigen targeted to phagocytic cells .
9160750	0	Th2	64,67	CD4	96,99	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells .
9175834	0	Th2	9,12	CD4	50,53	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	development|amod|START_ENTITY Impaired|dobj|development Impaired|nmod|absence absence|nmod|END_ENTITY	Impaired Th2 subset development in the absence of CD4 .
9378492	0	Th2	22,25	CD4	45,48	Th2	CD4	15111(Tax:10090)	920	Gene	Gene	cytokines|amod|START_ENTITY cytokines|nmod|effector effector|compound|END_ENTITY	Massive production of Th2 cytokines by human CD4 + effector T cells transiently expressing the natural killer cell marker CD57/HNK1 .
9378954	0	Th2	5,8	CD4	0,3	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CD4 + Th2 cells specific for mycobacterial 65-kilodalton heat shock protein protect against pristane-induced_arthritis .
9379016	0	Th2	102,105	CD4	97,100	Th2	CD4	15111(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Distinct roles for B7-1_and_B7-2 determinants during priming of effector CD8 + Tc1 and regulatory CD4 + Th2 cells for contact hypersensitivity .
10940889	0	Th2	66,69	CD40	110,114	Th2	CD40	15111(Tax:10090)	21939(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand -LRB- CD154 -RRB- expression on CD4 + T cells .
11777943	0	Th2	14,17	CD40	68,72	Th2	CD40	15111(Tax:10090)	21939(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY edge|dep|induction edge|dep|role role|nmod|END_ENTITY	Cutting edge : Th2 response induction by dendritic cells : a role for CD40 .
9808207	0	Th2	72,75	CD40	0,4	Th2	CD40	15111(Tax:10090)	21939(Tax:10090)	Gene	Gene	development|amod|START_ENTITY role|nmod|development signals|dep|role signals|nummod|END_ENTITY	CD40 ligand signals optimize T helper cell cytokine production : role in Th2 development and induction of germinal centers .
11067915	0	Th2	117,120	GATA-3	91,97	Th2	GATA-3	15111(Tax:10090)	14462(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY phosphorylation|nmod|expression phosphorylation|nmod|END_ENTITY	Cyclic_AMP activates p38 mitogen-activated protein kinase in Th2 cells : phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression .
21422152	0	Th2	26,29	IL-33	11,16	Th2	IL-33	15111(Tax:10090)	77125(Tax:10090)	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation .
23662055	0	Th2	98,101	IL-33	133,138	Th2	IL-33	15111(Tax:10090)	77125(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Intravenously delivered graphene nanosheets and multiwalled carbon nanotubes induce site-specific Th2 inflammatory responses via the IL-33 / ST2 axis .
10064056	0	Th2	52,55	IL-4	26,30	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY inhibits|nmod|cells inhibits|dobj|production production|compound|END_ENTITY	Lipid_A directly inhibits IL-4 production by murine Th2 cells but does not inhibit IFN-gamma production by Th1 cells .
10415077	0	Th2	53,56	IL-4	11,15	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY results|nmod|cells results|nsubj|expression expression|compound|END_ENTITY	Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse .
10429761	0	Th2	20,23	IL-4	40,44	Th2	IL-4	15111(Tax:10090)	3565	Gene	Gene	IL-3|amod|START_ENTITY IL-3|appos|END_ENTITY	Localization of the Th2 cytokines IL-3 , IL-4 , IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancy .
10706693	0	Th2	147,150	IL-4	34,38	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	profile|amod|START_ENTITY required|nmod|profile required|nsubjpass|receptor/Stat6 receptor/Stat6|compound|END_ENTITY	Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4 + lymphocytes with a Th2 cytokine profile .
10725711	0	Th2	73,76	IL-4	0,4	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cell|amod|START_ENTITY END_ENTITY|nmod|cell	IL-4 , IL-10 , IL-13 , and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis .
10727445	0	Th2	0,3	IL-4	103,107	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY dependent|nsubj|responses dependent|nmod|END_ENTITY	Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4 .
10975806	0	Th2	71,74	IL-4	29,33	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	clones|amod|START_ENTITY cluster|nmod|clones cluster|amod|cytokine cytokine|dep|END_ENTITY	Coordinate regulation of the IL-4 , IL-13 , and IL-5 cytokine cluster in Th2 clones revealed by allelic expression patterns .
11034364	0	Th2	74,77	IL-4	62,66	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	differentiation|amod|START_ENTITY provide|nmod|differentiation provide|dobj|source source|nmod|END_ENTITY	Conventional , naive CD4 + T cells provide an initial source of IL-4 during Th2 differentiation .
11465116	0	Th2	112,115	IL-4	87,91	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Reversal of established delayed type hypersensitivity_reactions following therapy with IL-4 or antigen-specific Th2 cells .
11981831	0	Th2	87,90	IL-4	0,4	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	differentiation|amod|START_ENTITY induce|dobj|differentiation secreted|xcomp|induce secreted|nsubj|END_ENTITY	IL-4 secreted from individual naive CD4 + T cells acts in an autocrine manner to induce Th2 differentiation .
12150887	0	Th2	28,31	IL-4	0,4	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY induces|dobj|responses induces|nsubj|END_ENTITY	IL-4 induces characteristic Th2 responses even in the combined absence of IL-5 , IL-9 , and IL-13 .
12218103	0	Th2	0,3	IL-4	70,74	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	activities|amod|START_ENTITY induced|nsubj|activities induced|nmod|cell cell|acl|priming priming|nmod|absence absence|nmod|IL-13 IL-13|compound|END_ENTITY	Th2 activities induced during virgin T cell priming in the absence of IL-4 , IL-13 , and B cells .
12444170	0	Th2	32,35	IL-4	47,51	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|appos|IFN-gamma IFN-gamma|dep|END_ENTITY	Increased nonobese diabetic Th1 : Th2 -LRB- IFN-gamma : IL-4 -RRB- ratio is CD4 + T cell intrinsic and independent of APC genetic background .
12646613	0	Th2	86,89	IL-4	78,82	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	Prevention of autoantibody-mediated Graves ' - like hyperthyroidism in mice with IL-4 , a Th2 cytokine .
14500651	0	Th2	71,74	IL-4	85,89	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY Induction|nmod|expression cytokines|nsubj|Induction cytokines|dobj|END_ENTITY	Induction of macrophage insulin-like_growth_factor-I expression by the Th2 cytokines IL-4 and IL-13 .
14646385	0	Th2	40,43	IL-4	21,25	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY promotes|nmod|cells promotes|dobj|production production|compound|END_ENTITY	Bisphenol_A promotes IL-4 production by Th2 cells .
14764670	0	Th2	46,49	IL-4	0,4	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	eosinophils|amod|START_ENTITY differentiation|nmod|eosinophils induces|dobj|differentiation induces|nsubj|END_ENTITY	IL-4 induces differentiation and expansion of Th2 cytokine-producing eosinophils .
1531351	0	Th2	15,18	IL-4	0,4	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	response|amod|START_ENTITY induces|dobj|response induces|nsubj|END_ENTITY	IL-4 induces a Th2 response in Leishmania_major-infected mice .
15699158	0	Th2	74,77	IL-4	19,23	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY development|nmod|cells drive|dobj|development drive|nsubj|END_ENTITY	IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites .
15712252	0	Th2	92,95	IL-4	73,77	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY induction|nmod|responses production|dep|induction production|amod|engineered engineered|xcomp|express express|dobj|END_ENTITY	Cytokine production by dendritic cells genetically engineered to express IL-4 : induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis .
16237061	0	Th2	74,77	IL-4	88,92	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY Induction|nmod|expression cytokines|nsubj|Induction cytokines|dobj|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- gene expression by the Th2 cytokines IL-4 and IL-13 .
18719110	0	Th2	69,72	IL-4	42,46	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	differentiation|amod|START_ENTITY signaling|nmod|differentiation reveal|xcomp|signaling reveal|dobj|role role|nmod|END_ENTITY	In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation .
18768853	0	Th2	21,24	IL-4	69,73	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY calcium|nmod|cells activates|nsubj|calcium activates|xcomp|induce induce|dobj|transcription transcription|compound|END_ENTITY	Elevating calcium in Th2 cells activates multiple pathways to induce IL-4 transcription and mRNA stabilization .
19201853	0	Th2	134,137	IL-4	118,122	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY produce|nmod|cells produce|iobj|END_ENTITY	Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4 / 13 , unlike Th2 and NKT cells .
19891612	0	Th2	67,70	IL-4	0,4	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cytokines|amod|START_ENTITY mice|dep|cytokines mice|amod|END_ENTITY	IL-4 -LRB- - / - -RRB- mice with lethal Mesocestoides corti infections -- reduced Th2 cytokines and alternatively activated macrophages .
21131429	0	Th2	15,18	IL-4	41,45	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|acl|skewing skewing|advcl|inhibiting inhibiting|dobj|production production|compound|END_ENTITY	SHIP represses Th2 skewing by inhibiting IL-4 production from basophils .
23195129	9	Th2	1454,1457	IL-4	1468,1472	Th2	TARC	15111(Tax:10090)	20295(Tax:10090)	Gene	Gene	cytokines|nsubj|START_ENTITY cytokines|dobj|END_ENTITY	COE significantly inhibited serum total IgE ; Th2 cytokines IL-4 , IL-5 and IL-13 ; pro-inflammatory cytokines IL-1b , IL6 and TNF-a ; the Th2 chemokine TARC and the pro-Th2 cytokine TSLP .
23743163	0	Th2	115,118	IL-4	81,85	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY inhibit|nmod|cells inhibit|dobj|secretion secretion|compound|END_ENTITY	Constituents of the anti-asthma herbal formula ASHMI -LRB- TM -RRB- synergistically inhibit IL-4 and IL-5 secretion by murine Th2 memory cells , and eotaxin by human lung fibroblasts in vitro .
8384701	0	Th2	42,45	IL-4	25,29	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY blocks|dobj|responses blocks|nsubj|Disruption Disruption|nmod|gene gene|compound|END_ENTITY	Disruption of the murine IL-4 gene blocks Th2 cytokine responses .
8613355	0	Th2	128,131	IL-4	36,40	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY associated|nsubjpass|cells reveals|ccomp|associated reveals|nsubj|immunization immunization|nmod|interleukin-4 interleukin-4|appos|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8906817	0	Th2	42,45	IL-4	20,24	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY END_ENTITY|nmod|responses	Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4 + NK1 .1 - T cell population .
9973471	0	Th2	48,51	IL-4	108,112	Th2	IL-4	15111(Tax:10090)	16189(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Th1|nmod|cells cross-regulation|nmod|Th1 Evidence|nmod|cross-regulation Evidence|dep|effects effects|nmod|Th1 Th1|acl|induced induced|nmod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
16373364	0	Th2	99,102	IL-5	71,75	Th2	IL-5	15111(Tax:10090)	16191(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	A role for Ets1 , synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes .
22424785	0	Th2	5,8	IL-6	99,103	Th2	IL-6	15111(Tax:10090)	16193(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY function|nsubj|cells function|nmod|deletion deletion|nmod|END_ENTITY	CD4 + Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene .
18538609	0	Th2	26,29	Interleukin-18	0,14	Th2	Interleukin-18	15111(Tax:10090)	16173(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice .
19638630	0	Th2	26,29	MyD88	86,91	Th2	MyD88	15111(Tax:10090)	17874(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM .
9692893	0	Th2	13,16	NF-kappaB	0,9	Th2	NF-kappaB	15111(Tax:10090)	18033(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	NF-kappaB in Th2 cells : delayed and long-lasting induction through the TCR complex .
10441165	0	Th2	0,3	PDGF-A	33,39	Th2	PDGF-A	15111(Tax:10090)	18590(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|acl|expressing expressing|dobj|END_ENTITY	Th2 T cells expressing transgene PDGF-A serve as vectors for gene therapy in autoimmune_demyelinating_disease .
21131429	0	Th2	15,18	SHIP	0,4	Th2	SHIP	15111(Tax:10090)	16331(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	SHIP represses Th2 skewing by inhibiting IL-4 production from basophils .
22361513	0	Th2	13,16	ST2	0,3	Th2	ST2	15111(Tax:10090)	17082(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	ST2 requires Th2 - , but not Th17 - , type airway_inflammation in epicutaneously antigen - sensitized mice .
25871878	0	Th2	19,22	STAT3	41,46	Th2	STAT3	15111(Tax:10090)	20848(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Dynamic control of Th2 cell responses by STAT3 during allergic_lung_inflammation in mice .
25871878	0	Th2	19,22	STAT3	41,46	Th2	STAT3	15111(Tax:10090)	20848(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Dynamic control of Th2 cell responses by STAT3 during allergic_lung_inflammation in mice .
11009098	0	Th2	25,28	STAT6	79,84	Th2	STAT6	15111(Tax:10090)	20852(Tax:10090)	Gene	Gene	development|amod|START_ENTITY development|nmod|activation activation|compound|END_ENTITY	TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression .
11907063	0	Th2	107,110	STAT6	132,137	Th2	STAT6	15111(Tax:10090)	20852(Tax:10090)	Gene	Gene	response|amod|START_ENTITY response|acl|induced induced|nmod|signaling signaling|compound|END_ENTITY	Cutting edge : susceptibility to the larval stage of the helminth parasite Taenia_crassiceps is mediated by Th2 response induced via STAT6 signaling .
19234162	0	Th2	28,31	STAT6	0,5	Th2	STAT6	15111(Tax:10090)	20852(Tax:10090)	Gene	Gene	afflicting|nsubj|START_ENTITY converts|xcomp|afflicting converts|nsubj|deletion deletion|compound|END_ENTITY	STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat -LRB- Y136F -RRB- mice into a lymphoproliferative_disorder involving Th1 and CD8 effector T cells .
20691018	0	Th2	124,127	STAT6	118,123	Th2	STAT6	15111(Tax:10090)	20852(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Protection against Naegleria_fowleri_infection in mice immunized with Cry1Ac plus amoebic lysates is dependent on the STAT6 Th2 response .
25145352	0	Th2	15,18	STAT6	49,54	Th2	STAT6	15111(Tax:10090)	20852(Tax:10090)	Gene	Gene	development|amod|START_ENTITY controls|dobj|development controls|advcl|targeting targeting|dobj|END_ENTITY	Grail controls Th2 cell development by targeting STAT6 for degradation .
8602264	0	Th2	21,24	Stat6	81,86	Th2	Stat6	15111(Tax:10090)	20852(Tax:10090)	Gene	Gene	response|compound|START_ENTITY Lack|nmod|response disrupted|nsubj|Lack disrupted|dobj|gene gene|amod|END_ENTITY	Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene .
10438342	0	Th2	0,3	Th1	65,68	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY converted|nsubjpass|responses converted|nmod|responses responses|amod|END_ENTITY	Th2 responses to inactivated influenza virus can Be converted to Th1 responses and facilitate recovery from heterosubtypic virus_infection .
10510367	0	Th2	58,61	Th1	104,107	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	differentiation|amod|START_ENTITY induction|nmod|differentiation induction|dep|regulation regulation|nmod|development development|amod|END_ENTITY	Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation : a feedback regulation of Th1 development .
10623798	0	Th2	14,17	Th1	155,158	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY Modulation|nmod|responses depends|nsubj|Modulation depends|nmod|END_ENTITY	Modulation of Th2 responses by peptide analogues in a murine model of allergic_asthma : amelioration or deterioration of the disease process depends on the Th1 or Th2 skewing characteristics of the therapeutic peptide .
10711700	0	Th2	11,14	Th1	0,3	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY END_ENTITY|nmod|responses	Th1 versus Th2 immune responses in autoimmune lacrimal gland_disease in MRL/Mp mice .
11013010	0	Th2	103,106	Th1	96,99	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	Down-regulation of interleukin-12 , interleukin-12R expression/activity mediates the switch from Th1 to Th2 granuloma response during murine Schistosomiasis mansoni .
11180117	0	Th2	102,105	Th1	95,98	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	phenotype|amod|START_ENTITY cytotoxic|nmod|phenotype cytotoxic|nmod|switch switch|nmod|END_ENTITY	Impaired development of HIV-1 gp160-specific CD8 -LRB- + -RRB- cytotoxic T cells by a delayed switch from Th1 to Th2 cytokine phenotype in mice with Helicobacter_pylori_infection .
11385621	0	Th2	109,112	Th1	121,124	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	generation|nmod|START_ENTITY required|nmod|generation required|nmod|cells cells|amod|END_ENTITY	More antigen-dependent CD4 -LRB- + -RRB- T cell / CD4 -LRB- + -RRB- T cell interactions are required for the primary generation of Th2 than of Th1 cells .
11937584	0	Th2	76,79	Th1	69,72	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|amod|START_ENTITY correlates|nmod|response correlates|nmod|switch switch|nmod|END_ENTITY	Preferential induction of IL-10 in APC correlates with a switch from Th1 to Th2 response following infection with a low pathogenic variant of Theiler 's _ virus .
12034094	0	Th2	96,99	Th1	14,17	Th2	Th1	15111(Tax:10090)	51497	Gene	Gene	mice|nmod|START_ENTITY HIV-1|nmod|mice responses|nmod|HIV-1 responses|amod|END_ENTITY	Generation of Th1 immune responses to inactivated , gp120-depleted HIV-1 in mice with a dominant Th2 biased immune profile via immunostimulatory -LSB- correction of imunostimulatory -RSB- oligonucleotides -- relevance to AIDS vaccines in developing countries .
12807487	0	Th2	139,142	Th1	148,151	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Induction of interleukin-12 production in mouse macrophages by berberine , a benzodioxoloquinolizine_alkaloid , deviates CD4 + T cells from a Th2 to a Th1 response .
14507448	0	Th2	47,50	Th1	54,57	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|type type|amod|END_ENTITY	Skin scratching switches immune responses from Th2 to Th1 type in epicutaneously immunized mice .
15240714	0	Th2	30,33	Th1	88,91	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|advcl|suppressing suppressing|dobj|development development|amod|END_ENTITY	CD25 + CD4 + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development .
15294955	0	Th2	17,20	Th1	101,104	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	polarization|amod|START_ENTITY associated|nsubjpass|polarization associated|nmod|responsiveness responsiveness|nmod|stimuli stimuli|amod|END_ENTITY	Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling .
15661889	0	Th2	61,64	Th1	36,39	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	development|amod|START_ENTITY inhibit|dobj|development ability|acl|inhibit ability|nmod|responses responses|amod|END_ENTITY	Limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo .
15987859	0	Th2	85,88	Th1	112,115	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	pole|amod|START_ENTITY balance|nmod|pole modulate|dobj|balance modulate|nmod|suppression suppression|nmod|development development|amod|END_ENTITY	Dietary -LRB- n-3 -RRB- polyunsaturated_fatty_acids modulate murine Th1/Th2 balance toward the Th2 pole by suppression of Th1 development .
16488475	0	Th2	99,102	Th1	9,12	Th2	Th1	15111(Tax:10090)	51497	Gene	Gene	switching|nmod|START_ENTITY followed|advcl|switching brucellosis|acl|followed onset|nmod|brucellosis cytokine|nmod|onset cytokine|nsubj|END_ENTITY	Dominant Th1 cytokine production in early onset of human brucellosis followed by switching towards Th2 along prolongation of disease .
16820320	0	Th2	57,60	Th1	50,53	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	induce|xcomp|START_ENTITY induce|dobj|END_ENTITY	Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver_injury in mice .
17597024	0	Th2	57,60	Th1	84,87	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|amod|START_ENTITY converts|dobj|response converts|nmod|response response|amod|END_ENTITY	Oral beta-glucan adjuvant therapy converts nonprotective Th2 response to protective Th1 cell-mediated immune response in mammary_tumor-bearing mice .
17641467	0	Th2	34,37	Th1	9,12	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	suppressive|nsubj|START_ENTITY suppressive|nmod|END_ENTITY	In vitro Th1 cytokine-independent Th2 suppressive effects of bifidobacteria .
1824635	0	Th2	67,70	Th1	18,21	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY induction|nmod|responses accompanies|dobj|induction accompanies|nsubj|Downregulation Downregulation|nmod|production production|amod|END_ENTITY	Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth , Schistosoma_mansoni .
18991278	0	Th2	26,29	Th1	64,67	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	cytokine|amod|START_ENTITY cytokine|acl:relcl|induces induces|dobj|END_ENTITY	Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function .
18991278	0	Th2	91,94	Th1	64,67	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	function|amod|START_ENTITY apoptosis|dobj|function apoptosis|nsubj|functions functions|nmod|cytokine cytokine|acl:relcl|induces induces|dobj|END_ENTITY	Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function .
19234162	0	Th2	28,31	Th1	128,131	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	afflicting|nsubj|START_ENTITY afflicting|nmod|lymphoproliferative_disorder lymphoproliferative_disorder|nmod|END_ENTITY	STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat -LRB- Y136F -RRB- mice into a lymphoproliferative_disorder involving Th1 and CD8 effector T cells .
19542428	0	Th2	102,105	Th1	39,42	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	effectors|amod|START_ENTITY development|nmod|effectors enhances|dobj|development Role|parataxis|enhances Role|nmod|differentiation differentiation|nmod|cells cells|amod|END_ENTITY	Role of CD44 in the differentiation of Th1 and Th2 cells : CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin .
20187766	0	Th2	101,104	Th1	94,97	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	profile|amod|START_ENTITY shifting|nmod|profile shifting|dobj|END_ENTITY	All-trans_retinoic_acid ameliorates trinitrobenzene_sulfonic_acid-induced colitis by shifting Th1 to Th2 profile .
20598563	0	Th2	7,10	Th1	0,3	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	deviation|amod|START_ENTITY END_ENTITY|nmod|deviation	Th1 to Th2 immune deviation facilitates , but does not cause , islet allograft tolerance in mice .
21086717	0	Th2	36,39	Th1	30,33	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	SerpinB2 deficiency modulates Th1 Th2 responses after schistosome infection .
22815380	0	Th2	84,87	Th1	35,38	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY induction|nmod|responses accompanies|dobj|induction accompanies|nsubj|downregulation downregulation|nmod|production production|amod|END_ENTITY	Pillars article : downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth , Schistosoma_mansoni .
24036270	0	Th2	51,54	Th1	44,47	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nmod|response	A novel chronic stress-induced shift in the Th1 to Th2 response promotes colon_cancer growth .
24442435	0	Th2	122,125	Th1	115,118	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	shift|amod|START_ENTITY induces|nmod|shift induces|dobj|END_ENTITY	Cleavage of the T cell protein tyrosine phosphatase by the hepatitis_C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy .
2531194	2	Th2	38,41	Th1	103,106	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	clones|amod|START_ENTITY secrete|nsubj|clones secrete|dobj|factor factor|acl:relcl|inhibits inhibits|nmod|clones clones|amod|END_ENTITY	Th2 clones secrete a factor that inhibits cytokine production by Th1 clones .
7594508	0	Th2	22,25	Th1	125,128	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY suppressors|nsubj|cells suppressors|nmod|experimental_autoimmune_encephalomyelitis experimental_autoimmune_encephalomyelitis|acl|induced induced|nmod|cells cells|amod|END_ENTITY	Neuroantigen-specific Th2 cells are inefficient suppressors of experimental_autoimmune_encephalomyelitis induced by effector Th1 cells .
8525508	0	Th2	20,23	Th1	35,38	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Expansion of memory Th2 cells over Th1 cells in neonatal primed mice .
8536362	0	Th2	60,63	Th1	54,57	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	switch|compound|START_ENTITY switch|compound|END_ENTITY	An immunosuppressive murine leukaemia virus induces a Th1 -- > Th2 switch and abrogates the IgM antibody response to sheep erythrocytes by suppressing the production of IL-2 .
8648216	0	Th2	115,118	Th1	102,105	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Oral immunization with the B subunit of the heat-labile enterotoxin of Escherichia_coli induces early Th1 and late Th2 cytokine expression in Peyer 's patches .
8752836	0	Th2	0,3	Th1	62,65	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY susceptible|nsubj|cells susceptible|xcomp|sphingosine sphingosine|nmod|cells cells|amod|END_ENTITY	Th2 suppressor cells are more susceptible to sphingosine than Th1 cells in murine contact photosensitivity .
9098720	0	Th2	162,165	Th1	139,142	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	mycobacterial|appos|START_ENTITY mycobacterial|appos|END_ENTITY	Effect of slow release IL-12 and IL-10 on inflammation , local macrophage function and the regional lymphoid response during mycobacterial -LRB- Th1 -RRB- and schistosomal -LRB- Th2 -RRB- antigen-elicited pulmonary_granuloma formation .
9237797	0	Th2	174,177	Th1	167,170	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	cytokines|amod|START_ENTITY associated|nmod|cytokines associated|nmod|switch switch|nmod|END_ENTITY	Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines .
9558102	0	Th2	76,79	Th1	15,18	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|amod|START_ENTITY activation|nmod|response response|nmod|activation response|amod|END_ENTITY	Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis .
9600317	0	Th2	147,150	Th1	136,139	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	subsets|amod|START_ENTITY END_ENTITY|nmod|subsets	Blockade of B7-2 , not B7-1 , inhibits purified protein derivative-primed T-lymphocyte responses but fails to influence the proportion of Th1 versus Th2 subsets .
9682366	0	Th2	40,43	Th1	76,79	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	response|amod|START_ENTITY response|nmod|mice mice|acl:relcl|shifts shifts|nmod|END_ENTITY	HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth_hormone .
9797511	0	Th2	11,14	Th1	4,7	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	shift|amod|START_ENTITY END_ENTITY|nmod|shift	The Th1 to Th2 shift induced by Schistosoma_mansoni does not exacerbate murine_aids -LRB- MAIDS -RRB- .
9916129	0	Th2	51,54	Th1	18,21	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	airway_hyperreactivity|amod|START_ENTITY counterbalance|dobj|airway_hyperreactivity fail|xcomp|counterbalance fail|nsubj|cells cells|compound|END_ENTITY	Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway_hyperreactivity but cause severe airway_inflammation .
9973471	0	Th2	48,51	Th1	41,44	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
9973471	0	Th2	48,51	Th1	93,96	Th2	Th1	15111(Tax:10090)	57314(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Th1|nmod|cells cross-regulation|nmod|Th1 Evidence|nmod|cross-regulation Evidence|dep|effects effects|nmod|END_ENTITY	Evidence of positive cross-regulation on Th1 by Th2 and antigen-presenting cells : effects on Th1 induced by IL-4 and IL-12 .
11970998	0	Th2	60,63	Toll-like_receptor_4	0,20	Th2	Toll-like receptor 4	15111(Tax:10090)	21898(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY development|nmod|responses required|nmod|development required|nsubjpass|END_ENTITY	Toll-like_receptor_4 is required for optimal development of Th2 immune responses : role of dendritic cells .
19380786	0	Th2	15,18	Ym1/2	0,5	Th2	Ym1/2	15111(Tax:10090)	12655;104183	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15 -LRB- S -RRB- - lipoxygenase : identification of a novel pathway for regulating allergic_inflammation .
24530901	0	Th2	57,60	apolipoprotein_E	73,89	Th2	apolipoprotein E	15111(Tax:10090)	11816(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Allergic_asthma accelerates atherosclerosis dependent on Th2 and Th17 in apolipoprotein_E deficient mice .
11093173	0	Th2	81,84	cutaneous_lymphocyte-associated_antigen	14,53	Th2	cutaneous lymphocyte-associated antigen	15111(Tax:10090)	6404	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of cutaneous_lymphocyte-associated_antigen on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- Th2 cells .
14500651	0	Th2	71,74	insulin-like_growth_factor-I	24,52	Th2	insulin-like growth factor-I	15111(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of macrophage insulin-like_growth_factor-I expression by the Th2 cytokines IL-4 and IL-13 .
16237061	0	Th2	74,77	uteroglobin-related_protein_2	13,42	Th2	uteroglobin-related protein 2	15111(Tax:10090)	68662(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- gene expression by the Th2 cytokines IL-4 and IL-13 .
24880459	0	ThPOK	25,30	Runx3	42,47	ThPOK	Runx3	51043	864	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	The transcription factor ThPOK suppresses Runx3 and imposes CD4 -LRB- + -RRB- lineage fate by inducing the SOCS suppressors of cytokine signaling .
8468055	0	Thbs3	62,67	thrombospondin_3	44,60	Thbs3	thrombospondin 3	21827(Tax:10090)	21827(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation and characterization of the mouse thrombospondin_3 -LRB- Thbs3 -RRB- gene .
12748127	0	Theg	22,26	testicular_haploid_expressed_gene	28,61	Theg	testicular haploid expressed gene	21830(Tax:10090)	21830(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Male mice lacking the Theg -LRB- testicular_haploid_expressed_gene -RRB- protein undergo normal spermatogenesis and are fertile .
7829089	0	Thermolabile_phenol_sulfotransferase	0,36	STM	43,46	Thermolabile phenol sulfotransferase	STM	445329	6818	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thermolabile_phenol_sulfotransferase gene -LRB- STM -RRB- : localization to human chromosome 16p11 .2 .
25494835	0	Thi3p	94,99	PDC1	103,107	Thi3p	PDC1	851479(Tax:4932)	850733(Tax:4932)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Deciphering regulatory variation of THI genes in alcoholic fermentation indicate an impact of Thi3p on PDC1 expression .
24072708	0	Thioesterase_superfamily_member_2	0,33	Acyl-CoA_thioesterase_13	34,58	Thioesterase superfamily member 2	Acyl-CoA thioesterase 13	66834(Tax:10090)	66834(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Thioesterase_superfamily_member_2 / Acyl-CoA_thioesterase_13 -LRB- Them2/Acot13 -RRB- regulates adaptive thermogenesis in mice .
17026564	0	Thiopurine_methyltransferase	0,28	TPMT	30,34	Thiopurine methyltransferase	TPMT	7172	7172	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Thiopurine_methyltransferase -LRB- TPMT -RRB- activity and adverse effects of azathioprine in inflammatory_bowel_disease : long-term follow-up study of 394 patients .
12089063	0	Thioredoxin	0,11	ASK1	21,25	Thioredoxin	ASK1	7295	4217	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner .
17724081	0	Thioredoxin	0,11	ASK1	173,177	Thioredoxin	ASK1	7295	4217	Gene	Gene	proteins|amod|START_ENTITY regulate|nsubj|proteins regulate|nmod|modulation modulation|nmod|interaction interaction|nmod|END_ENTITY	Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1 .
17724081	0	Thioredoxin	0,11	ASK1	94,98	Thioredoxin	ASK1	7295	4217	Gene	Gene	proteins|amod|START_ENTITY regulate|nsubj|proteins regulate|dobj|activation activation|nmod|END_ENTITY	Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1 .
23747528	0	Thioredoxin	0,11	ASK1	35,39	Thioredoxin	ASK1	22166(Tax:10090)	26408(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|function function|nsubj|MPK38-induced MPK38-induced|nummod|END_ENTITY	Thioredoxin inhibits MPK38-induced ASK1 , TGF-b , and p53 function in a phosphorylation-dependent manner .
26660634	0	Thioredoxin	93,104	ASK1	119,123	Thioredoxin	ASK1	7295	4217	Gene	Gene	Inhibition|compound|START_ENTITY Inhibition|nmod|END_ENTITY	MiR-17 Downregulation by High Glucose Stabilizes Thioredoxin-Interacting_Protein and Removes Thioredoxin Inhibition on ASK1 Leading to Apoptosis .
11896592	0	Thioredoxin	0,11	H19	47,50	Thioredoxin	H19	7295	283120	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Thioredoxin post-transcriptional regulation by H19 provides a new function to mRNA-like non-coding RNA .
21963718	0	Thioredoxin	0,11	MMP-9	23,28	Thioredoxin	MMP-9	7295	4318	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Thioredoxin stimulates MMP-9 expression , de-regulates the MMP-9 / TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231_breast_cancer cells .
1508666	0	Thioredoxin	0,11	NF-kappa_B	50,60	Thioredoxin	NF-kappa B	7295	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Thioredoxin regulates the DNA binding activity of NF-kappa_B by reduction of a disulphide bond involving cysteine 62 .
23747528	0	Thioredoxin	0,11	TGF-b	41,46	Thioredoxin	TGF-b	22166(Tax:10090)	21803(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|ccomp|function function|nsubj|MPK38-induced MPK38-induced|nummod|END_ENTITY	Thioredoxin inhibits MPK38-induced ASK1 , TGF-b , and p53 function in a phosphorylation-dependent manner .
24281068	0	Thioredoxin	0,11	Thioredoxin	35,46	Thioredoxin	Thioredoxin	7295	7295	Gene	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Thioredoxin and Cancer : A Role for Thioredoxin in all States of Tumor Oxygenation .
24281068	0	Thioredoxin	35,46	Thioredoxin	0,11	Thioredoxin	Thioredoxin	7295	7295	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|dep|Role	Thioredoxin and Cancer : A Role for Thioredoxin in all States of Tumor Oxygenation .
21705327	0	Thioredoxin	0,11	Txnip	76,81	Thioredoxin	Txnip	7295	10628	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|stability stability|amod|thioredoxin-interacting_protein thioredoxin-interacting_protein|dep|END_ENTITY	Thioredoxin regulates adipogenesis through thioredoxin-interacting_protein -LRB- Txnip -RRB- protein stability .
15480426	0	Thioredoxin	0,11	activator_protein_1	22,41	Thioredoxin	activator protein 1	7295	3725	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	Thioredoxin modulates activator_protein_1 -LRB- AP-1 -RRB- activity and p27Kip1 degradation through direct interaction with Jab1 .
10329406	0	Thioredoxin	0,11	p38	33,36	Thioredoxin	p38	22166(Tax:10090)	26416(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor_necrosis_factor-alpha .
26130523	0	Thioredoxin	28,39	thioredoxin_reductase	4,25	Thioredoxin	thioredoxin reductase	7295	25824	Gene	Gene	system|compound|START_ENTITY cleaves|nsubj|system END_ENTITY|parataxis|cleaves	The thioredoxin_reductase - Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles .
10329406	0	Thioredoxin	0,11	tumor_necrosis_factor-alpha	82,109	Thioredoxin	tumor necrosis factor-alpha	22166(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor_necrosis_factor-alpha .
18848838	0	Thioredoxin-1	0,13	PPARalpha	108,117	Thioredoxin-1	PPARalpha	7295	5465	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Thioredoxin-1 and its natural inhibitor , vitamin_D3_up-regulated_protein_1 , are differentially regulated by PPARalpha in human macrophages .
11877442	0	Thioredoxin-2	0,13	thioredoxin_peroxidase-1	54,78	Thioredoxin-2	thioredoxin peroxidase-1	34281(Tax:7227)	53578(Tax:7227)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin_peroxidase-1 from Drosophila_melanogaster : isolation and characterization of a second thioredoxin in D. _ Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2 .
26796253	0	Thioredoxin-Interacting_Protein	50,81	ITCH	30,34	Thioredoxin-Interacting Protein	ITCH	56338(Tax:10090)	16396(Tax:10090)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting_Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity .
25138219	0	Thioredoxin-Interacting_Protein	84,115	NLRP3	29,34	Thioredoxin-Interacting Protein	NLRP3	56338(Tax:10090)	216799(Tax:10090)	Gene	Gene	Injury|nmod|START_ENTITY Inflammasome|dobj|Injury Inflammasome|nsubj|Nod-like_Receptor_Protein_3 Nod-like_Receptor_Protein_3|appos|END_ENTITY	Nod-like_Receptor_Protein_3 -LRB- NLRP3 -RRB- Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting_Protein -LRB- TXNIP -RRB- during Hyperhomocysteinemia .
25391656	0	Thioredoxin-interacting_Protein	27,58	Zeb1	73,77	Thioredoxin-interacting Protein	Zeb1	10628	6935	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	MicroRNA-200 Is Induced by Thioredoxin-interacting_Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis .
23520550	0	Thioredoxin-interacting_protein	0,31	MondoA	52,58	Thioredoxin-interacting protein	MondoA	10628	22877	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Thioredoxin-interacting_protein gene expression via MondoA is rapidly and transiently suppressed during inflammatory responses .
25017793	0	Thioredoxin-interacting_protein	0,31	NALP3	41,46	Thioredoxin-interacting protein	NALP3	10628	114548	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Thioredoxin-interacting_protein mediates NALP3 inflammasome activation in podocytes during diabetic_nephropathy .
24201577	0	Thioredoxin-interacting_protein	0,31	NLRP3	60,65	Thioredoxin-interacting protein	NLRP3	117514(Tax:10116)	287362(Tax:10116)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Thioredoxin-interacting_protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet .
20558747	0	Thioredoxin-interacting_protein	0,31	Txnip	33,38	Thioredoxin-interacting protein	Txnip	10628	10628	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thioredoxin-interacting_protein -LRB- Txnip -RRB- gene expression : sensing oxidative phosphorylation status and glycolytic rate .
19885567	0	Thioredoxin2	0,12	mtTFA	58,63	Thioredoxin2	mtTFA	25828	7019	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	Thioredoxin2 enhances the damaged DNA binding activity of mtTFA through direct interaction .
25854388	0	Thioredoxin_Interacting_Protein	35,66	TXNIP	68,73	Thioredoxin Interacting Protein	TXNIP	10628	10628	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Hypoxia Induced High Expression of Thioredoxin_Interacting_Protein -LRB- TXNIP -RRB- in Non-small_Cell_Lung_Cancer and its Prognostic Effect .
22113441	0	Thioredoxin_interacting_protein	0,31	TXNIP	33,38	Thioredoxin interacting protein	TXNIP	10628	10628	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Thioredoxin_interacting_protein -LRB- TXNIP -RRB- rs7212 polymorphism is associated with arterial stiffness in the Brazilian general population .
11410332	0	Thioredoxin_reductase	0,21	glutathione_peroxidase	38,60	Thioredoxin reductase	glutathione peroxidase	25824	2876	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Thioredoxin_reductase and cytoplasmic glutathione_peroxidase activity in human foetal_and_neonatal_liver .
22130674	0	Thp5	34,38	interleukin-4	47,60	Thp5	interleukin-4	70123(Tax:10090)	3565	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	CD4 + T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4 + T cells to direct T helper 2 cell differentiation .
20032511	0	Thrombin	0,8	AP-1	46,50	Thrombin	AP-1	29251(Tax:10116)	24516(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Thrombin induces endothelial arginase through AP-1 activation .
18665919	0	Thrombin	0,8	Bid	49,52	Thrombin	Bid	2147	637	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Thrombin induces activation and translocation of Bid , Bax and Bak to the mitochondria in human platelets .
27034473	0	Thrombin	26,34	Biglycan	8,16	Thrombin	Biglycan	14061(Tax:10090)	12111(Tax:10090)	Gene	Gene	Generation|compound|START_ENTITY Generation|compound|END_ENTITY	Loss of Biglycan Enhances Thrombin Generation in ApoE-Deficient Mice Implications for Inflammation and Atherosclerosis .
9654134	0	Thrombin	0,8	CD38	67,71	Thrombin	CD38	2147	952	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	Thrombin induces the association of cyclic_ADP-ribose-synthesizing CD38 with the platelet cytoskeleton .
18418252	0	Thrombin	0,8	CD40	19,23	Thrombin	CD40	2147	958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Thrombin regulates CD40 expression in microglial cells .
26350460	0	Thrombin	0,8	CDC25	83,88	Thrombin	CDC25	2147	995	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase_C-epsilon .
19628787	0	Thrombin	0,8	EGF_receptor	17,29	Thrombin	EGF receptor	29251(Tax:10116)	24329(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Thrombin induces EGF_receptor expression and cell proliferation via a PKC -LRB- delta -RRB- / c-Src-dependent pathway in vascular smooth muscle cells .
16148030	0	Thrombin	0,8	FGF-2	31,36	Thrombin	FGF-2	2147	2247	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells .
17968311	0	Thrombin	0,8	FGF-2	129,134	Thrombin	FGF-2	2147	2247	Gene	Gene	cleaves|nsubj|START_ENTITY cleaves|dobj|forms forms|dep|mechanism mechanism|nmod|control control|nmod|activity activity|compound|END_ENTITY	Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor -LRB- FGF-2 -RRB- : a novel mechanism for the control of FGF-2 and thrombin activity .
17968311	0	Thrombin	0,8	FGF-2	84,89	Thrombin	FGF-2	2147	2247	Gene	Gene	cleaves|nsubj|START_ENTITY cleaves|dobj|forms forms|nmod|factor factor|appos|END_ENTITY	Thrombin cleaves the high molecular weight forms of basic fibroblast growth factor -LRB- FGF-2 -RRB- : a novel mechanism for the control of FGF-2 and thrombin activity .
12719784	0	Thrombin	0,8	GPIbalpha	20,29	Thrombin	GPIbalpha	2147	2811	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Thrombin binding to GPIbalpha induces platelet_aggregation and fibrin clot retraction supported by resting alphaIIbbeta3 interaction with polymerized fibrin .
14961148	0	Thrombin	0,8	GPIbalpha	20,29	Thrombin	GPIbalpha	2147	2811	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Thrombin binding to GPIbalpha induces integrin alphaIIbbeta3 dependent platelet_adhesion to fibrin in ex vivo flowing whole blood .
7482442	0	Thrombin	0,8	GRO_alpha	17,26	Thrombin	GRO alpha	2147	2919	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Thrombin induces GRO_alpha / MGSA production in human umbilical vein endothelial cells .
11150588	0	Thrombin	0,8	HCII	23,27	Thrombin	HCII	2147	3053	Gene	Gene	inhibition|nsubj|START_ENTITY inhibition|nmod|END_ENTITY	Thrombin inhibition by HCII in the presence of elastase-cleaved HCII and thrombin-HCII complex .
16551735	0	Thrombin	0,8	HOXA10	40,46	Thrombin	HOXA10	2147	3206	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells : implications for preterm_labor .
24506791	0	Thrombin	0,8	ICAM-1	17,23	Thrombin	ICAM-1	2147	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Thrombin induces ICAM-1 expression in human lung epithelial cells via c-Src/PDGFR/PI3K / Akt-dependent NF-kB/p300 activation .
17115897	0	Thrombin	0,8	IFN-gamma	18,27	Thrombin	IFN-gamma	2147	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Thrombin inhibits IFN-gamma production in human peripheral blood mononuclear cells by promoting a Th2 profile .
11997699	0	Thrombin	0,8	IL-10	17,22	Thrombin	IL-10	29251(Tax:10116)	25325(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Thrombin induces IL-10 production in microglia as a negative feedback regulator of TNF-alpha release .
11104585	0	Thrombin	0,8	IL-6	17,21	Thrombin	IL-6	14061(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Thrombin induces IL-6 but not TNFalpha secretion by mouse mast cells : threshold-level thrombin_receptor and very low level FcepsilonRI signaling synergistically enhance IL-6 secretion .
14719142	0	Thrombin	0,8	IL-6	20,24	Thrombin	IL-6	2147	3569	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Thrombin stimulates IL-6 and IL-8 expression in cytomegalovirus-infected human retinal pigment epithelial cells .
7608566	0	Thrombin	0,8	IL-6	17,21	Thrombin	IL-6	2147	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Thrombin induces IL-6 production in fibroblasts and epithelial cells .
20564194	0	Thrombin	0,8	MCP-1	94,99	Thrombin	MCP-1	2147	6347	Gene	Gene	motility|compound|START_ENTITY motility|nmod|GRO GRO|dep|expression expression|nmod|END_ENTITY	Thrombin stimulates RPE cell motility by PKC-zeta - and NF-kappaB-dependent gene expression of MCP-1 and CINC-1 / GRO chemokines .
21787749	0	Thrombin	0,8	MCP-1	17,22	Thrombin	MCP-1	14061(Tax:10090)	20296(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-kB signaling pathway activation in vascular endothelial cells .
7482442	0	Thrombin	0,8	MGSA	27,31	Thrombin	MGSA	2147	2919	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Thrombin induces GRO_alpha / MGSA production in human umbilical vein endothelial cells .
25047892	0	Thrombin	0,8	MMP-2	89,94	Thrombin	MMP-2	29251(Tax:10116)	81686(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|parataxis|involvement involvement|nmod|END_ENTITY	Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway : involvement of MMP-2 .
11360674	0	Thrombin	0,8	MMP-9	20,25	Thrombin	MMP-9	14061(Tax:10090)	17395(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Thrombin stimulates MMP-9 mRNA expression through AP-1 pathway in human mesangial cells .
1721912	0	Thrombin	0,8	PAI-1	56,61	Thrombin	PAI-1	2147	5054	Gene	Gene	neutralizes|nsubj|START_ENTITY neutralizes|dobj|plasminogen_activator_inhibitor_1 plasminogen_activator_inhibitor_1|appos|END_ENTITY	Thrombin neutralizes plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- that is complexed with vitronectin in the endothelial cell matrix .
12052165	0	Thrombin	0,8	PAR-1	50,55	Thrombin	PAR-1	2147	2149	Gene	Gene	antagonists|amod|START_ENTITY antagonists|dep|advances advances|nmod|development development|compound|END_ENTITY	Thrombin receptor antagonists ; recent advances in PAR-1 antagonist development .
18571697	0	Thrombin	0,8	PAR-1	74,79	Thrombin	PAR-1	2147	2149	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|vascular vascular|dobj|synthesis synthesis|nmod|pathways pathways|amod|END_ENTITY	Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways .
20144050	0	Thrombin	0,8	PAR-1	19,24	Thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Thrombin receptor -LRB- PAR-1 -RRB- antagonists as novel antithrombotic agents .
20506163	0	Thrombin	0,8	PAR-1	167,172	Thrombin	PAR-1	2147	2149	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|nmod|activation activation|nmod|END_ENTITY	Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1 .
22212430	0	Thrombin	0,8	PAR-1	104,109	Thrombin	PAR-1	29251(Tax:10116)	25439(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY cells|dep|expression cells|nmod|END_ENTITY	Thrombin induced connective_tissue_growth_factor expression in rat vascular smooth muscle cells via the PAR-1 / JNK/AP -1 pathway .
23919450	0	Thrombin	0,8	PAR-1	55,60	Thrombin	PAR-1	2147	2149	Gene	Gene	induces|nsubj|START_ENTITY induces|ccomp|pathways pathways|nsubj|transition transition|nmod|END_ENTITY	Thrombin induces epithelial-mesenchymal transition via PAR-1 , PKC , and ERK1/2 pathways in A549 cells .
9493599	0	Thrombin	0,8	PAR-1	83,88	Thrombin	PAR-1	29251(Tax:10116)	25439(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|nmod|mechanism mechanism|amod|mediated mediated|amod|END_ENTITY	Thrombin stimulates smooth muscle cell procollagen synthesis and mRNA levels via a PAR-1 mediated mechanism .
15572532	0	Thrombin	0,8	PAR1	60,64	Thrombin	PAR1	2147	2149	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-epsilon .
18353977	0	Thrombin	0,8	PAR1	75,79	Thrombin	PAR1	14061(Tax:10090)	14062(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|signaling signaling|nsubj|production production|nmod|coupling coupling|nmod|Galphaq Galphaq|compound|END_ENTITY	Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Galphaq and cooperation between ERK1/2 and Rho_kinase signaling pathways .
20442298	0	Thrombin	0,8	PAR1	94,98	Thrombin	PAR1	2147	2149	Gene	Gene	regulates|nsubj|START_ENTITY regulates|parataxis|signaling signaling|nsubj|role role|nmod|END_ENTITY	Thrombin regulates the metastatic potential of human rhabdomyosarcoma cells : distinct role of PAR1 and PAR3 signaling .
9486135	0	Thrombin	0,8	PLA2	61,65	Thrombin	PLA2	2147	151056	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Thrombin activates a membrane-associated calcium-independent PLA2 in ventricular myocytes .
26350460	0	Thrombin	0,8	Phospholipase_C-epsilon	120,143	Thrombin	Phospholipase C-epsilon	2147	5334	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras Associating Domains of Phospholipase_C-epsilon .
26468766	0	Thrombin	64,72	Thrombomodulin	0,14	Thrombin	Thrombomodulin	2147	7056	Gene	Gene	Form|nmod|START_ENTITY Selects|dobj|Form Selects|nsubj|Binding Binding|compound|END_ENTITY	Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin .
25303460	0	Thrombin	0,8	Tissue_Factor_Pathway_Inhibitor	24,55	Thrombin	Tissue Factor Pathway Inhibitor	2147	7035	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Thrombin Down-Regulates Tissue_Factor_Pathway_Inhibitor Expression in a PI3K/Nuclear Factor-kB-Dependent Manner in Human Pleural Mesothelial Cells .
11686329	0	Thrombin	0,8	VEGF	55,59	Thrombin	VEGF	2147	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts , DU145 prostate cells and CHRF megakaryocytes .
25310246	0	Thrombin	21,29	VEGF	33,37	Thrombin	VEGF	2147	7422	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|Secretion Secretion|compound|END_ENTITY	Different Effects of Thrombin on VEGF Secretion , Proliferation , and Permeability in Polarized and Non-polarized Retinal Pigment Epithelial Cells .
26340413	0	Thrombin	0,8	VIII	62,66	Thrombin	VIII	2147	1351	Gene	Gene	assay|compound|START_ENTITY using|nsubj|assay using|nmod|END_ENTITY	Thrombin generation assay using factor XIa to measure factors VIII and IX and their glycoPEGylated derivatives is robust and sensitive .
638056	0	Thrombin	0,8	VIII	30,34	Thrombin	VIII	2147	1351	Gene	Gene	activation|compound|START_ENTITY activation|nmod|factor factor|nummod|END_ENTITY	Thrombin activation of factor VIII .
3382640	0	Thrombin	0,8	acidic_fibroblast_growth_factor	21,52	Thrombin	acidic fibroblast growth factor	280685(Tax:9913)	281160(Tax:9913)	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	Thrombin inactivates acidic_fibroblast_growth_factor but not basic fibroblast growth factor .
10235452	0	Thrombin	0,8	amyloid_precursor_protein	56,81	Thrombin	amyloid precursor protein	2147	351	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Thrombin induces surface and intracellular secretion of amyloid_precursor_protein from human endothelial cells .
11246533	0	Thrombin	0,8	angiopoietin-1	32,46	Thrombin	angiopoietin-1	2147	284	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Thrombin induces the release of angiopoietin-1 from platelets .
11861279	0	Thrombin	0,8	angiopoietin-2	55,69	Thrombin	angiopoietin-2	2147	285	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells .
16442510	0	Thrombin	0,8	antithrombin	23,35	Thrombin	antithrombin	2147	462	Gene	Gene	inhibition|nsubj|START_ENTITY inhibition|nmod|END_ENTITY	Thrombin inhibition by antithrombin in the presence of oversulfated dermatan sulfates .
5673827	0	Thrombin	0,8	antithrombin	72,84	Thrombin	antithrombin	2147	462	Gene	Gene	activity|compound|START_ENTITY obtained|nsubj|activity obtained|nmod|filtration filtration|nmod|plasma plasma|compound|END_ENTITY	Thrombin inhibitory activity of fractions obtained by gel filtration of antithrombin 3 deficient plasma .
7272951	0	Thrombin	0,8	antithrombin	64,76	Thrombin	antithrombin	2147	462	Gene	Gene	inhibition|compound|START_ENTITY inhibition|dep|effect effect|compound|END_ENTITY	Thrombin inhibition by malignant and normal cells : a cell-bound antithrombin effect .
9409233	0	Thrombin	0,8	antithrombin_III	99,115	Thrombin	antithrombin III	29251(Tax:10116)	304917(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|acl:relcl|binds binds|dobj|END_ENTITY	Thrombin stimulates syndecan-1 promotor activity and expression of a form of syndecan-1 that binds antithrombin_III in vascular smooth muscle cells .
17416972	0	Thrombin	0,8	aquaporin_4	18,29	Thrombin	aquaporin 4	29251(Tax:10116)	25293(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Thrombin inhibits aquaporin_4 expression through protein_kinase_C-dependent pathway in cultured astrocytes .
8768694	0	Thrombin	0,8	atrial_natriuretic_peptide	20,46	Thrombin	atrial natriuretic peptide	29251(Tax:10116)	24602(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Thrombin stimulates atrial_natriuretic_peptide secretion from rat cardiac atrium .
9039085	0	Thrombin	0,8	atrial_natriuretic_peptide	18,44	Thrombin	atrial natriuretic peptide	280685(Tax:9913)	281355(Tax:9913)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Thrombin inhibits atrial_natriuretic_peptide receptor activity in cultured bovine endothelial cells .
15201277	0	Thrombin	0,8	c-Fos	139,144	Thrombin	c-Fos	2147	2353	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dep|regulation regulation|nmod|END_ENTITY	Thrombin and tumor_necrosis_factor_alpha synergistically stimulate tissue factor expression in human endothelial cells : regulation through c-Fos and c-Jun .
2119237	0	Thrombin	0,8	c-fos	17,22	Thrombin	c-fos	2147	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2 -LRB- + -RRB- - dependent mechanism .
8607120	0	Thrombin	0,8	c-fos	68,73	Thrombin	c-fos	2147	2353	Gene	Gene	peptide|amod|START_ENTITY stimulates|nsubj|peptide stimulates|dobj|END_ENTITY	Thrombin receptor activating peptide -LRB- TRAP -RRB- stimulates mitogenesis , c-fos and PDGF-A gene expression in human vascular smooth muscle cells .
2426251	0	Thrombin	0,8	c-sis	20,25	Thrombin	c-sis	2147	5155	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Thrombin stimulates c-sis gene expression in microvascular endothelial cells .
18559512	0	Thrombin	0,8	cathepsin_D	22,33	Thrombin	cathepsin D	2147	1509	Gene	Gene	up-regulates|compound|START_ENTITY END_ENTITY|nsubj|up-regulates	Thrombin up-regulates cathepsin_D which enhances angiogenesis , growth , and metastasis .
22212430	0	Thrombin	0,8	connective_tissue_growth_factor	17,48	Thrombin	connective tissue growth factor	29251(Tax:10116)	64032(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Thrombin induced connective_tissue_growth_factor expression in rat vascular smooth muscle cells via the PAR-1 / JNK/AP -1 pathway .
19616539	0	Thrombin	0,8	cyclooxygenase-2	17,33	Thrombin	cyclooxygenase-2	2147	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts .
19739103	0	Thrombin	0,8	cyclooxygenase-2	17,33	Thrombin	cyclooxygenase-2	14061(Tax:10090)	19225(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thrombin induces cyclooxygenase-2 expression and prostaglandin_E2 release via PAR1 activation and ERK1/2 - and p38_MAPK-dependent pathway in murine macrophages .
11390977	0	Thrombin	0,8	dbpB	50,54	Thrombin	dbpB	2147	4904	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Thrombin induces the release of the Y-box protein dbpB from mRNA : a mechanism of transcriptional activation .
11577023	0	Thrombin	0,8	endothelial_nitric_oxide_synthase	20,53	Thrombin	endothelial nitric oxide synthase	2147	4846	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Thrombin suppresses endothelial_nitric_oxide_synthase and upregulates endothelin-converting_enzyme-1 expression by distinct pathways : role of Rho/ROCK and mitogen-activated protein kinase .
2215247	0	Thrombin	0,8	endothelin-1	53,65	Thrombin	endothelin-1	2147	1906	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|cells cells|amod|END_ENTITY	Thrombin stimulates the production of immunoreactive endothelin-1 in cultured human umbilical vein endothelial cells .
7679602	0	Thrombin	0,8	endothelin-1	38,50	Thrombin	endothelin-1	29251(Tax:10116)	24323(Tax:10116)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Thrombin is a regulator of astrocytic endothelin-1 .
9612302	0	Thrombin	0,8	endothelin-1	23,35	Thrombin	endothelin-1	2147	1906	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells .
11577023	0	Thrombin	0,8	endothelin-converting_enzyme-1	70,100	Thrombin	endothelin-converting enzyme-1	2147	1889	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Thrombin suppresses endothelial_nitric_oxide_synthase and upregulates endothelin-converting_enzyme-1 expression by distinct pathways : role of Rho/ROCK and mitogen-activated protein kinase .
12968031	0	Thrombin	0,8	factor_XI	23,32	Thrombin	factor XI	2147	2160	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Thrombin activation of factor_XI on activated platelets requires the interaction of factor_XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II , respectively .
11401083	0	Thrombin	0,8	fibrinogen	48,58	Thrombin	fibrinogen	2147	2244	Gene	Gene	converts|nsubj|START_ENTITY converts|dobj|oxygen oxygen|acl:relcl|oxidized oxidized|dobj|END_ENTITY	Thrombin converts singlet oxygen -LRB- 1O2 -RRB- - oxidized fibrinogen into a soluble t-PA cofactor .
1581297	0	Thrombin	0,8	fibrinogen	50,60	Thrombin	fibrinogen	2147	2244	Gene	Gene	hydrolysis|compound|START_ENTITY hydrolysis|nmod|peptide peptide|nmod|Lille Lille|compound|END_ENTITY	Thrombin hydrolysis of an N-terminal peptide from fibrinogen Lille : kinetic and NMR studies .
8726231	0	Thrombin	0,8	fibrinogen	58,68	Thrombin	fibrinogen	2147	2244	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|xcomp|reduce reduce|dobj|accumulation accumulation|nmod|activity activity|compound|END_ENTITY	Thrombin inhibitors reduce intrapulmonary accumulation of fibrinogen and procoagulant activity of bronchoalveolar lavage fluid during acute_lung_injury induced by pulmonary_overdistention in newborn piglets .
9326231	0	Thrombin	0,8	fibrinogen	44,54	Thrombin	fibrinogen	2147	2244	Gene	Gene	deposition|amod|START_ENTITY deposition|nmod|END_ENTITY	Thrombin cleavage-independent deposition of fibrinogen in extracellular matrices .
11701462	0	Thrombin	0,8	interleukin-6	17,30	Thrombin	interleukin-6	2147	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells .
9281306	0	Thrombin	0,8	interleukin-6	19,32	Thrombin	interleukin-6	14061(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|synthesis synthesis|amod|END_ENTITY	Thrombin regulates interleukin-6 synthesis through phosphatidylcholine hydrolysis by phospholipase D in osteoblasts .
10657945	0	Thrombin	0,8	interleukin-8	21,34	Thrombin	interleukin-8	2147	3576	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	Thrombin upregulates interleukin-8 in lung fibroblasts via cleavage of proteolytically activated receptor-I and protein kinase C-gamma activation .
8707354	0	Thrombin	0,8	interleukin-8	34,47	Thrombin	interleukin-8	2147	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|cells cells|amod|END_ENTITY	Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells .
24385683	0	Thrombin	0,8	matrix_metalloproteinase-13	18,45	Thrombin	matrix metalloproteinase-13	2147	4322	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Thrombin promotes matrix_metalloproteinase-13 expression through the PKC c-Src/EGFR/PI3K / Akt/AP -1 signaling pathway in human chondrocytes .
17346550	0	Thrombin	0,8	monocyte_chemoattractant_protein-1	19,53	Thrombin	monocyte chemoattractant protein-1	2147	6347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Thrombin regulates monocyte_chemoattractant_protein-1 expression in human first trimester and term decidual cells .
18622025	0	Thrombin	0,8	monocyte_chemoattractant_protein-1	36,70	Thrombin	monocyte chemoattractant protein-1	29251(Tax:10116)	24770(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|production production|acl|END_ENTITY	Thrombin enhances the production of monocyte_chemoattractant_protein-1 and macrophage_inflammatory_protein-2 in cultured rat glomerular epithelial cells .
7641321	0	Thrombin	0,8	monocyte_chemoattractant_protein-1	33,67	Thrombin	monocyte chemoattractant protein-1	2147	6347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Thrombin regulates expression of monocyte_chemoattractant_protein-1 in vascular smooth muscle cells .
19652200	0	Thrombin	0,8	oncostatin_M	35,47	Thrombin	oncostatin M	2147	5008	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Thrombin induces the expression of oncostatin_M via AP-1 activation in human macrophages : a link between coagulation and inflammation .
18565131	0	Thrombin	0,8	osteoprotegerin	17,32	Thrombin	osteoprotegerin	2147	4982	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|compound|END_ENTITY	Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3 ' - kinase/mammalian _ target_of_rapamycin pathway in human periodontal ligament cells .
7499191	0	Thrombin	0,8	p38_MAP_kinase	31,45	Thrombin	p38 MAP kinase	2147	1432	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Thrombin induces activation of p38_MAP_kinase in human platelets .
1689102	0	Thrombin	0,8	plasmin	13,20	Thrombin	plasmin	2147	5340	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	Thrombin vs. plasmin generation in disseminated_intravascular_coagulation associated with various underlying disorders .
2418059	0	Thrombin	0,8	plasminogen_activator-inhibitor	22,53	Thrombin	plasminogen activator-inhibitor	2147	5054	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Thrombin induction of plasminogen_activator-inhibitor in cultured human endothelial cells .
7559545	0	Thrombin	0,8	progelatinase_A	35,50	Thrombin	progelatinase A	2147	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Thrombin induces the activation of progelatinase_A in vascular endothelial cells .
26742564	0	Thrombin	0,8	protease-activated_receptor-3	42,71	Thrombin	protease-activated receptor-3	2147	2151	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	Thrombin stimulates insulin secretion via protease-activated_receptor-3 .
12431976	0	Thrombin	0,8	protein_kinase_D	25,41	Thrombin	protein kinase D	2147	5587	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Thrombin rapidly induces protein_kinase_D phosphorylation , and protein_kinase_C_delta mediates the activation .
20128804	0	Thrombin	0,8	proteinase-activated_receptor_1	23,54	Thrombin	proteinase-activated receptor 1	2147	2149	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Thrombin activation of proteinase-activated_receptor_1 potentiates the myofilament Ca2 + sensitivity and induces vasoconstriction in porcine pulmonary arteries .
10552902	0	Thrombin	0,8	sp1	41,44	Thrombin	sp1	2147	6667	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Thrombin activates transcription factors sp1 , NF-kappaB , and CREB : importance of the use of phosphatase inhibitors during nuclear protein extraction for the assessment of transcription factor DNA-binding activities .
9409233	0	Thrombin	0,8	syndecan-1	20,30	Thrombin	syndecan-1	29251(Tax:10116)	25216(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Thrombin stimulates syndecan-1 promotor activity and expression of a form of syndecan-1 that binds antithrombin_III in vascular smooth muscle cells .
12467301	0	Thrombin	0,8	thrombin	48,56	Thrombin	thrombin	2147	2147	Gene	Gene	START_ENTITY|dep|activation activation|compound|END_ENTITY	Thrombin as a survival factor for cancer cells : thrombin activation in malignant effusions in vivo and inhibition of idarubicin-induced cell death in vitro .
11967197	0	Thrombin	0,8	thrombin_receptor	36,53	Thrombin	thrombin receptor	280685(Tax:9913)	526585(Tax:9913)	Gene	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Thrombin generation and presence of thrombin_receptor in ovarian follicles .
9178727	0	Thrombin	0,8	thrombin_receptor	82,99	Thrombin	thrombin receptor	280685(Tax:9913)	526585(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin_receptor in cultured bovine smooth muscle cells .
10464282	0	Thrombin	0,8	thrombomodulin	24,38	Thrombin	thrombomodulin	2147	7056	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Thrombin interacts with thrombomodulin , protein C , and thrombin-activatable_fibrinolysis_inhibitor via specific and distinct domains .
18568955	0	Thrombin	0,8	thrombomodulin	23,37	Thrombin	thrombomodulin	2147	7056	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells .
7613475	0	Thrombin	0,8	thrombomodulin	44,58	Thrombin	thrombomodulin	2147	7056	Gene	Gene	inhibition|nsubj|START_ENTITY inhibition|nmod|END_ENTITY	Thrombin inhibition by cyclic peptides from thrombomodulin .
9178727	0	Thrombin	0,8	thrombomodulin	17,31	Thrombin	thrombomodulin	280685(Tax:9913)	281529(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin_receptor in cultured bovine smooth muscle cells .
15817447	0	Thrombin	0,8	thrombospondin-1	62,78	Thrombin	thrombospondin-1	2147	7057	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|set set|nmod|genes genes|nmod|cells cells|amod|END_ENTITY	Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells .
8094535	0	Thrombin	0,8	tissue-plasminogen_activator	65,93	Thrombin	tissue-plasminogen activator	2147	100128998	Gene	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Thrombin generation and myocardial_infarction during infusion of tissue-plasminogen_activator .
7583589	0	Thrombin	0,8	tissue_factor_pathway_inhibitor	57,88	Thrombin	tissue factor pathway inhibitor	2147	7035	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Thrombin induces the redistribution and acute release of tissue_factor_pathway_inhibitor from specific granules within human endothelial cells in culture .
2501229	0	Thrombin	0,8	tissue_plasminogen_activator	29,57	Thrombin	tissue plasminogen activator	280685(Tax:9913)	281407(Tax:9913)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|release release|nmod|END_ENTITY	Thrombin enhances release of tissue_plasminogen_activator from bovine corneal endothelial cells .
6542570	0	Thrombin	0,8	tissue_plasminogen_activator	20,48	Thrombin	tissue plasminogen activator	2147	100128998	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Thrombin stimulates tissue_plasminogen_activator release from cultured human endothelial cells .
9075121	0	Thrombin	0,8	transforming_growth_factor-beta	34,65	Thrombin	transforming growth factor-beta	2147	7040	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Thrombin stimulates production of transforming_growth_factor-beta by cultured human mesangial cells .
12493764	0	Thrombin	0,8	vascular_adhesion_molecule-1	24,52	Thrombin	vascular adhesion molecule-1	2147	7412	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Thrombin stimulation of vascular_adhesion_molecule-1 in endothelial cells is mediated by protein_kinase_C _ -LRB- PKC -RRB- - delta-NF-kappa B and PKC-zeta-GATA signaling pathways .
6403080	0	Thrombin	0,8	viii	40,44	Thrombin	viii	2147	1351	Gene	Gene	proteolysis|compound|START_ENTITY proteolysis|nmod|protein protein|compound|END_ENTITY	Thrombin proteolysis of purified factor viii procoagulant protein : correlation of activation with generation of a specific polypeptide .
8807714	0	Thrombin	0,8	vitronectin	61,72	Thrombin	vitronectin	2147	7448	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Thrombin regulation by physiological inhibitors : the role of vitronectin .
12529754	0	Thrombin_activatable_fibrinolysis_inhibitor	0,43	TAFI	45,49	Thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- levels in patients with coronary_artery_disease investigated by angiography .
11413145	0	Thrombin_receptor	0,17	Hsp90	53,58	Thrombin receptor	Hsp90	14062(Tax:10090)	111058(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Thrombin_receptor signaling to cytoskeleton requires Hsp90 .
25225421	0	Thrombomodulin	43,57	THBD	64,68	Thrombomodulin	THBD	7056	7056	Gene	Gene	Gene|compound|START_ENTITY END_ENTITY|nmod|Gene	Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene -LRB- THBD -RRB- Predict Mortality in Patients With Graft-Versus-Host_Disease .
12617986	0	Thrombomodulin	0,14	THP-1	29,34	Thrombomodulin	THP-1	7056	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Thrombomodulin expression by THP-1 but not by vascular endothelial cells is upregulated by pioglitazone .
26468766	0	Thrombomodulin	0,14	Thrombin	64,72	Thrombomodulin	Thrombin	7056	2147	Gene	Gene	Binding|compound|START_ENTITY Selects|nsubj|Binding Selects|dobj|Form Form|nmod|END_ENTITY	Thrombomodulin Binding Selects the Catalytically Active Form of Thrombin .
10416810	0	Thrombomodulin	0,14	familial_hypercholesterolemia	38,67	Thrombomodulin	familial hypercholesterolemia	7056	3949	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Thrombomodulin levels in asymptomatic familial_hypercholesterolemia .
11257732	0	Thrombomodulin	0,14	thrombin	28,36	Thrombomodulin	thrombin	7056	2147	Gene	Gene	START_ENTITY|dep|receptor receptor|compound|END_ENTITY	Thrombomodulin -- endothelial thrombin receptor in blood of patients with unstable angina_pectoris .
1320301	0	Thrombomodulin	0,14	thrombin	33,41	Thrombomodulin	thrombin	100008887(Tax:9986)	100009146(Tax:9986)	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|degradation degradation|compound|END_ENTITY	Thrombomodulin is a cofactor for thrombin degradation of recombinant single-chain urokinase plasminogen activator `` in vitro '' and in a perfused rabbit heart model .
14523228	0	Thrombomodulin	0,14	thrombin	74,82	Thrombomodulin	thrombin	7056	2147	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin .
16274226	0	Thrombomodulin	0,14	thrombin	28,36	Thrombomodulin	thrombin	7056	2147	Gene	Gene	tightens|nsubj|START_ENTITY tightens|dobj|loops loops|amod|END_ENTITY	Thrombomodulin tightens the thrombin active site loops to promote protein C activation .
21788337	0	Thrombomodulin	0,14	thrombin	80,88	Thrombomodulin	thrombin	21824(Tax:10090)	14061(Tax:10090)	Gene	Gene	determinant|nsubj|START_ENTITY determinant|nmod|metastasis metastasis|nmod|mechanism mechanism|acl|linked linked|nmod|domain domain|compound|END_ENTITY	Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain .
22178578	0	Thrombomodulin	0,14	thrombin	62,70	Thrombomodulin	thrombin	21824(Tax:10090)	14061(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|W215A/E217A W215A/E217A|amod|END_ENTITY	Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial_thrombosis .
6313646	0	Thrombomodulin	0,14	thrombin	37,45	Thrombomodulin	thrombin	7056	2147	Gene	Gene	blocks|nsubj|START_ENTITY blocks|dobj|ability ability|nmod|END_ENTITY	Thrombomodulin blocks the ability of thrombin to activate platelets .
9425093	0	Thrombomodulin	0,14	thrombin	37,45	Thrombomodulin	thrombin	7056	2147	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|rate rate|nmod|inhibition inhibition|compound|END_ENTITY	Thrombomodulin increases the rate of thrombin inhibition by BPTI .
9569203	0	Thrombomodulin	0,14	thrombin	51,59	Thrombomodulin	thrombin	7056	2147	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Thrombomodulin modulates the mitogenic response to thrombin of human umbilical vein endothelial cells .
11756417	0	Thrombopoietin	0,14	Bcl-xL	25,31	Thrombopoietin	Bcl-xL	7066	598	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways .
9845531	0	Thrombopoietin	0,14	Crkl	38,42	Thrombopoietin	Crkl	7066	1399	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets .
14670916	0	Thrombopoietin	0,14	FLT3-ligand	31,42	Thrombopoietin	FLT3-ligand	7066	2323	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors .
15705785	0	Thrombopoietin	0,14	HIF-1alpha	134,144	Thrombopoietin	HIF-1alpha	21832(Tax:10090)	15251(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|induction induction|nmod|END_ENTITY	Thrombopoietin enhances expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in primitive hematopoietic cells through induction of HIF-1alpha .
18473128	0	Thrombopoietin	0,14	HIF-1alpha	31,41	Thrombopoietin	HIF-1alpha	7066	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species .
12855555	0	Thrombopoietin	0,14	Hoxb4	26,31	Thrombopoietin	Hoxb4	21832(Tax:10090)	15412(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Thrombopoietin stimulates Hoxb4 expression : an explanation for the favorable effects of TPO on hematopoietic stem cells .
16368886	0	Thrombopoietin	0,14	IEX-1	25,30	Thrombopoietin	IEX-1	7066	8870	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Thrombopoietin regulates IEX-1 gene expression through ERK-induced AML1 phosphorylation .
12372629	0	Thrombopoietin	0,14	LIF	41,44	Thrombopoietin	LIF	21832(Tax:10090)	16878(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic_stem cells homozygous for a Shp-2 deletion mutation .
8751457	0	Thrombopoietin	0,14	MPL	43,46	Thrombopoietin	MPL	7066	4352	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Thrombopoietin : expression of its receptor MPL and proliferative effects on leukemic cells .
10517496	0	Thrombopoietin	0,14	Mpl	71,74	Thrombopoietin	Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|protein protein|acl:relcl|binds binds|nmod|END_ENTITY	Thrombopoietin induces an SH2-containing protein , CIS1 , which binds to Mpl : involvement of the ubiquitin proteosome pathway .
9028319	0	Thrombopoietin	0,14	PI_3_kinase	125,136	Thrombopoietin	PI 3 kinase	7066	5295	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Thrombopoietin enhances the alpha IIb beta_3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI_3_kinase .
11097834	0	Thrombopoietin	0,14	STAT5	64,69	Thrombopoietin	STAT5	7066	6776	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|END_ENTITY	Thrombopoietin and interleukin-2 induce association of CRK with STAT5 .
7544303	0	Thrombopoietin	0,14	STAT5	72,77	Thrombopoietin	STAT5	7066	6776	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- induces tyrosine phosphorylation and activation of STAT5 and STAT3 .
9845531	0	Thrombopoietin	0,14	STAT5	48,53	Thrombopoietin	STAT5	7066	6776	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|Crkl Crkl|nmod|END_ENTITY	Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets .
8555464	0	Thrombopoietin	0,14	Stat3	51,56	Thrombopoietin	Stat3	7066	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets .
11756417	0	Thrombopoietin	0,14	Stat5	56,61	Thrombopoietin	Stat5	7066	6776	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways .
15763973	0	Thrombopoietin	0,14	TPO	16,19	Thrombopoietin	TPO	7066	7066	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Thrombopoietin -LRB- TPO -RRB- levels in hepatic patients with thrombocytopenia .
26575027	0	Thrombopoietin	21,35	TPO	37,40	Thrombopoietin	TPO	7066	7066	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	Markedly High Plasma Thrombopoietin -LRB- TPO -RRB- Level is a Predictor of Poor Response to Immunosuppressive Therapy in Children With Acquired Severe Aplastic_Anemia .
10224114	0	Thrombopoietin	0,14	TYK2	65,69	Thrombopoietin	TYK2	7066	7297	Gene	Gene	transduction|compound|START_ENTITY requires|nsubj|transduction requires|dobj|JAK2 JAK2|appos|END_ENTITY	Thrombopoietin signal transduction requires functional JAK2 , not TYK2 .
7589510	0	Thrombopoietin	0,14	Tyk2	66,70	Thrombopoietin	Tyk2	7066	7297	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Thrombopoietin , c-Mpl_ligand , induces tyrosine phosphorylation of Tyk2 , JAK2 , and STAT3 , and enhances agonists-induced aggregation in platelets in vitro .
9663467	0	Thrombopoietin	0,14	c-Mpl	85,90	Thrombopoietin	c-Mpl	7066	4352	Gene	Gene	supports|nsubj|START_ENTITY supports|nmod|differentiation differentiation|nmod|END_ENTITY	Thrombopoietin supports in vitro erythroid differentiation via its specific receptor c-Mpl in a human leukemia cell line .
18814950	0	Thrombopoietin	0,14	c-Myb	25,30	Thrombopoietin	c-Myb	7066	4602	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression .
11478766	0	Thrombopoietin	0,14	c-mpl	66,71	Thrombopoietin	c-mpl	7066	4352	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Thrombopoietin induces histidine_decarboxylase gene expression in c-mpl transfected UT7 cells .
7535585	0	Thrombopoietin	0,14	erythropoietin	56,70	Thrombopoietin	erythropoietin	21832(Tax:10090)	13856(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Thrombopoietin -LRB- c-mpl_ligand -RRB- acts synergistically with erythropoietin , stem_cell_factor , and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro .
11478766	0	Thrombopoietin	0,14	histidine_decarboxylase	23,46	Thrombopoietin	histidine decarboxylase	7066	3067	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thrombopoietin induces histidine_decarboxylase gene expression in c-mpl transfected UT7 cells .
11944912	0	Thrombopoietin	0,14	p-selectin	23,33	Thrombopoietin	p-selectin	7066	6403	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions .
8639822	0	Thrombopoietin	0,14	steel_factor	65,77	Thrombopoietin	steel factor	21832(Tax:10090)	17311(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Thrombopoietin , the ligand for the Mpl receptor , synergizes with steel_factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice .
8695789	0	Thrombopoietin	0,14	steel_factor	93,105	Thrombopoietin	steel factor	7066	4254	Gene	Gene	supports|nsubj|START_ENTITY supports|nmod|END_ENTITY	Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel_factor and/or interleukin-3 .
16258288	0	Thrombopoietin	0,14	vascular_endothelial_cell_growth_factor	26,65	Thrombopoietin	vascular endothelial cell growth factor	7066	7422	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Thrombopoietin stimulates vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- production in hematopoietic stem cells .
15705785	0	Thrombopoietin	0,14	vascular_endothelial_growth_factor	38,72	Thrombopoietin	vascular endothelial growth factor	21832(Tax:10090)	22339(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Thrombopoietin enhances expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in primitive hematopoietic cells through induction of HIF-1alpha .
1383273	0	Thrombospondin	0,14	CD36	31,35	Thrombospondin	CD36	7057	948	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis .
1384794	0	Thrombospondin	0,14	CD36	37,41	Thrombospondin	CD36	7057	948	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|adherence adherence|nmod|reticulocytes reticulocytes|compound|END_ENTITY	Thrombospondin mediates adherence of CD36 + sickle reticulocytes to endothelial cells .
2877688	0	Thrombospondin	0,14	factor_XIIIa	52,64	Thrombospondin	factor XIIIa	7057	2162	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Thrombospondin is a substrate for blood_coagulation factor_XIIIa .
18946489	0	Thrombospondin-1	0,16	ApoER2	26,32	Thrombospondin-1	ApoER2	7057	7804	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Thrombospondin-1 binds to ApoER2 and VLDL_receptor and functions in postnatal neuronal migration .
24148348	0	Thrombospondin-1	0,16	CD36	17,21	Thrombospondin-1	CD36	21825(Tax:10090)	12491(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|END_ENTITY	Thrombospondin-1 / CD36 pathway contributes to bone marrow-derived angiogenic cell dysfunction in type 1 diabetes via Sonic_hedgehog pathway suppression .
19952644	0	Thrombospondin-1	0,16	CD47	17,21	Thrombospondin-1	CD47	445442(Tax:10116)	29364(Tax:10116)	Gene	Gene	ischemia-reperfusion_injury|nummod|START_ENTITY ischemia-reperfusion_injury|compound|END_ENTITY	Thrombospondin-1 / CD47 blockade following ischemia-reperfusion_injury is tissue protective .
20923780	0	Thrombospondin-1	0,16	CD47	87,91	Thrombospondin-1	VEGF	7057	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|VEGF_receptor-2 VEGF_receptor-2|acl|signaling signaling|advcl|disrupting disrupting|nmod|END_ENTITY	Thrombospondin-1 inhibits VEGF_receptor-2 signaling by disrupting its association with CD47 .
23087362	0	Thrombospondin-1	0,16	CD47	42,46	Thrombospondin-1	CD47	7057	961	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|flow flow|nmod|activation activation|nummod|END_ENTITY	Thrombospondin-1 regulates blood flow via CD47 receptor-mediated activation of NADPH_oxidase_1 .
23591719	0	Thrombospondin-1	0,16	CD47	35,39	Thrombospondin-1	CD47	21825(Tax:10090)	16423(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors .
25697354	0	Thrombospondin-1	121,137	CD47	156,160	thrombospondin-1	CD47	7057	961	Gene	Gene	Signaling|compound|START_ENTITY Blocked|nmod|Signaling Blocked|nmod|Protein Protein|compound|END_ENTITY	Photodynamic Therapy-mediated Cancer Vaccination Enhances Stem-like Phenotype and Immune Escape , Which Can Be Blocked by Thrombospondin-1 Signaling through CD47 Receptor Protein .
26813769	0	Thrombospondin-1	9,25	CD47	96,100	Thrombospondin-1	CD47	7057	961	Gene	Gene	Macrophage|compound|START_ENTITY Interleukin-1b|nsubj|Macrophage Interleukin-1b|nmod|END_ENTITY	Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1b Production and Activation through CD47 .
20631908	0	Thrombospondin-1	0,16	Integrin_alpha6	50,65	Thrombospondin-1	Integrin alpha6	7057	3655	Gene	Gene	START_ENTITY|dep|Expression Expression|nmod|END_ENTITY	Thrombospondin-1 -LRB- TSP-1 -RRB- Stimulates Expression of Integrin_alpha6 in Human Breast_Carcinoma Cells : A Downstream Modulator of TSP-1-Induced Cellular Adhesion .
19509293	0	Thrombospondin-1	0,16	PRMT6	59,64	Thrombospondin-1	PRMT6	7057	55170	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Thrombospondin-1 is a transcriptional repression target of PRMT6 .
23846726	0	Thrombospondin-1	0,16	Runx2	46,51	Thrombospondin-1	Runx2	21825(Tax:10090)	12393(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Thrombospondin-1 is a putative target gene of Runx2 and Runx3 .
22583901	0	Thrombospondin-1	0,16	TGF-b	100,105	Thrombospondin-1	TGF-b	7057	7040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|activation activation|compound|END_ENTITY	Thrombospondin-1 inhibits osteogenic differentiation of human mesenchymal stem cells through latent TGF-b activation .
26992552	0	Thrombospondin-1	0,16	TGFb	65,69	Thrombospondin-1	TGFb	7057	7040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Thrombospondin-1 promotes mesenchymal stromal cell functions via TGFb and in cooperation with PDGF .
20923780	0	Thrombospondin-1	0,16	VEGF_receptor-2	26,41	Thrombospondin-1	VEGF receptor-2	7057	3791	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Thrombospondin-1 inhibits VEGF_receptor-2 signaling by disrupting its association with CD47 .
12844104	0	Thrombospondin-1	0,16	matrix_metalloproteinase-2	25,51	Thrombospondin-1	matrix metalloproteinase-2	281530(Tax:9913)	282872(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	Thrombospondin-1 induces matrix_metalloproteinase-2 activation in vascular smooth muscle cells .
15519514	0	Thrombospondin-1	0,16	p53	43,46	Thrombospondin-1	p53	7057	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|status status|compound|END_ENTITY	Thrombospondin-1 expression in relation to p53 status and VEGF expression in human breast_cancers .
9243511	0	Thrombospondin-1	0,16	platelet-endothelial_cell_adhesion_molecule-1	65,110	Thrombospondin-1	platelet-endothelial cell adhesion molecule-1	21825(Tax:10090)	18613(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Thrombospondin-1 , a natural inhibitor of angiogenesis , regulates platelet-endothelial_cell_adhesion_molecule-1 expression and endothelial cell morphogenesis .
22105716	0	Thrombospondin-1	0,16	transforming_growth_factor-beta1	103,135	Thrombospondin-1	transforming growth factor-beta1	21825(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activation activation|amod|END_ENTITY	Thrombospondin-1 is a novel negative regulator of liver_regeneration after partial hepatectomy through transforming_growth_factor-beta1 activation in mice .
15172186	0	Thrombospondin-1	0,16	urokinase_plasminogen_activator_receptor	62,102	Thrombospondin-1	urokinase plasminogen activator receptor	7057	5329	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|nmod|END_ENTITY	Thrombospondin-1 up-regulates tumor cell invasion through the urokinase_plasminogen_activator_receptor in head_and_neck cancer cells .
11856116	0	Thrombospondin-1	0,16	vascular_endothelial_growth_factor	18,52	Thrombospondin-1	vascular endothelial growth factor	7057	7422	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Thrombospondin-1 , vascular_endothelial_growth_factor expression and their relationship with p53 status in_prostate_cancer and benign_prostatic_hyperplasia .
12814678	0	Thrombospondin-1	0,16	vascular_endothelial_growth_factor	18,52	Thrombospondin-1	vascular endothelial growth factor	7057	7422	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Thrombospondin-1 , vascular_endothelial_growth_factor expression and microvessel density in renal_cell_carcinoma and their relationship with multifocality .
19528255	0	Thrombospondin-1	0,16	vascular_endothelial_growth_factor	27,61	Thrombospondin-1	vascular endothelial growth factor	21825(Tax:10090)	22339(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	Thrombospondin-1 modulates vascular_endothelial_growth_factor activity at the receptor level .
10448307	0	Thrombospondin-2	0,16	TSP2	18,22	Thrombospondin-2	TSP2	7058	7058	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Thrombospondin-2 -LRB- TSP2 -RRB- expression is inversely correlated with vascularity in glioma .
23954950	0	Thrombospondin_1	0,16	Toll-like_receptor_4	42,62	Thrombospondin 1	Toll-like receptor 4	7057	7099	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Thrombospondin_1 activates the macrophage Toll-like_receptor_4 pathway .
8408036	0	Thrombospondin_1	0,16	cathepsin_G	72,83	Thrombospondin 1	cathepsin G	7057	1511	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Thrombospondin_1 is a tight-binding competitive inhibitor of neutrophil cathepsin_G .
19915562	0	Thrombospondin_1	0,16	neuroligin_1	75,87	Thrombospondin 1	neuroligin 1	445442(Tax:10116)	116647(Tax:10116)	Gene	Gene	accelerates|nsubj|START_ENTITY accelerates|nmod|END_ENTITY	Thrombospondin_1 accelerates synaptogenesis in hippocampal neurons through neuroligin_1 .
10926856	0	Thrombospondin_1	0,16	transforming_growth_factor_beta1	35,67	Thrombospondin 1	transforming growth factor beta1	445442(Tax:10116)	59086(Tax:10116)	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Thrombospondin_1 does not activate transforming_growth_factor_beta1 in a chemically defined system or in smooth-muscle-cell cultures .
10378888	0	Thy-1	102,107	CD34	0,4	Thy-1	CD34	7070	947	Gene	Gene	+|amod|START_ENTITY subset|amod|+ repopulating|nmod|subset marrow|acl|repopulating retain|dobj|marrow retain|nsubj|cells cells|nummod|END_ENTITY	CD34 + cells from mobilized peripheral blood retain fetal bone marrow repopulating capacity within the Thy-1 + subset following cell division ex vivo .
10378891	0	Thy-1	125,130	CD34	119,123	Thy-1	CD34	7070	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Thrombopoietin , flt3 , and kit ligands together suppress apoptosis of human mobilized CD34 + cells and recruit primitive CD34 + Thy-1 + cells into rapid division .
10557051	0	Thy-1	51,56	CD34	99,103	Thy-1	CD34	7070	947	Gene	Gene	CD90|appos|START_ENTITY aberrations|nmod|CD90 Detection|nmod|aberrations Detection|dep|subfractions subfractions|appos|END_ENTITY	Detection of cytogenetic aberrations both in CD90 -LRB- Thy-1 -RRB- - positive and -LRB- Thy-1 -RRB- - negative stem cell -LRB- CD34 -RRB- subfractions of patients with acute and chronic_myeloid_leukemias .
10634171	0	Thy-1	106,111	CD34	91,95	Thy-1	CD34	21838(Tax:10090)	12490(Tax:10090)	Gene	Gene	+|appos|START_ENTITY +|dep|+ END_ENTITY|dep|+	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
11313664	0	Thy-1	41,46	CD34	49,53	Thy-1	CD34	7070	947	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Transplantation of a fetus with paternal Thy-1 -LRB- + -RRB- CD34 -LRB- + -RRB- cells for chronic granulomatous_disease .
14662335	0	Thy-1	11,16	CD34	0,4	Thy-1	CD34	7070	947	Gene	Gene	CDw90|appos|START_ENTITY CDw90|compound|END_ENTITY	CD34 + CDw90 -LRB- Thy-1 -RRB- + subset colocated with mesenchymal progenitors in human normal bone marrow hematon units is enriched in colony-forming unit megakaryocytes and long-term culture-initiating cells .
15625845	0	Thy-1	38,43	CD34	32,36	Thy-1	CD34	7070	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	-LSB- The implication of circulating CD34 + Thy-1 -LRB- + -RRB- cells measurement during autologous peripheral blood stem cell mobilization -RSB- .
7475307	0	Thy-1	41,46	CD34	36,40	Thy-1	CD34	7070	947	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Cytokine-mobilized peripheral blood CD34 + Thy-1 + Lin - human hematopoietic stem cells as target cells for transplantation-based gene therapy .
7529060	0	Thy-1	65,70	CD34	60,64	Thy-1	CD34	7070	947	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Enrichment of human hematopoietic stem cell activity in the CD34 + Thy-1 + Lin - subpopulation from mobilized_peripheral_blood .
7540889	0	Thy-1	20,25	CD34	48,52	Thy-1	CD34	7070	947	Gene	Gene	expression|compound|START_ENTITY Characterization|nmod|expression Characterization|nmod|acute_leukemia acute_leukemia|compound|END_ENTITY	Characterization of Thy-1 -LRB- CDw90 -RRB- expression in CD34 + acute_leukemia .
8542956	0	Thy-1	30,35	CD34	25,29	Thy-1	CD34	7070	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Optimizing the CD34 + and CD34 + Thy-1 + stem cell content of peripheral blood collections .
8608259	0	Thy-1	68,73	CD34	17,21	Thy-1	CD34	21838(Tax:10090)	12490(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY cells|nmod|expression differ|dobj|cells differ|nsubj|cells cells|nummod|END_ENTITY	Peripheral blood CD34 + cells differ from bone marrow CD34 + cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte_colony-stimulating_factor and/or stem_cell_factor .
8608259	0	Thy-1	68,73	CD34	53,57	Thy-1	CD34	21838(Tax:10090)	12490(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY cells|nmod|expression cells|nummod|END_ENTITY	Peripheral blood CD34 + cells differ from bone marrow CD34 + cells in Thy-1 expression and cell cycle status in nonhuman primates mobilized or not mobilized with granulocyte_colony-stimulating_factor and/or stem_cell_factor .
8647230	0	Thy-1	83,88	CD34	18,22	Thy-1	CD34	101109906	101105675	Gene	Gene	Lin|compound|START_ENTITY engraftment|nmod|Lin selection|dep|engraftment stem|nsubj|selection subsets|advcl|stem subsets|nsubj|Identification Identification|nmod|+ +|compound|END_ENTITY	Identification of CD34 + subsets after glycoprotease selection : engraftment of CD34 + Thy-1 + Lin - stem cells in fetal sheep .
8647230	0	Thy-1	83,88	CD34	78,82	Thy-1	CD34	101109906	101105675	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Identification of CD34 + subsets after glycoprotease selection : engraftment of CD34 + Thy-1 + Lin - stem cells in fetal sheep .
8724526	0	Thy-1	5,10	CD34	0,4	Thy-1	CD34	7070	947	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	CD34 + Thy-1 + Lin - stem cells from mobilized_peripheral_blood .
8781417	0	Thy-1	119,124	CD34	114,118	Thy-1	CD34	7070	947	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Thrombopoietin stimulates megakaryocytopoiesis , myelopoiesis , and expansion of CD34 + progenitor cells from single CD34 + Thy-1 + Lin - primitive progenitor cells .
8781417	0	Thy-1	119,124	CD34	79,83	Thy-1	CD34	7070	947	Gene	Gene	Lin|compound|START_ENTITY cells|nmod|Lin cells|nummod|END_ENTITY	Thrombopoietin stimulates megakaryocytopoiesis , myelopoiesis , and expansion of CD34 + progenitor cells from single CD34 + Thy-1 + Lin - primitive progenitor cells .
8943851	0	Thy-1	104,109	CD34	99,103	Thy-1	CD34	7070	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Transplantation and gene transfer of the human glucocerebrosidase gene into immunoselected primate CD34 + Thy-1 + cells .
9028155	0	Thy-1	8,13	CD34	29,33	Thy-1	CD34	7070	947	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	-LSB- CDw90 -LRB- Thy-1 -RRB- expression on CD34 positive cells in peripheral blood stem cell harvest -RSB- .
9192752	0	Thy-1	61,66	CD34	55,59	Thy-1	CD34	7070	947	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	Hematopoietic potential and retroviral transduction of CD34 + Thy-1 + peripheral blood stem cells from asymptomatic human_immunodeficiency_virus_type-1-infected individuals mobilized with granulocyte colony-stimulating factor .
9261934	0	Thy-1	12,17	CD34	43,47	Thy-1	CD34	7070	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Decrease in Thy-1 expression on peripheral CD34 positive cells induced by G-CSF mobilization .
9454750	0	Thy-1	138,143	CD34	133,137	Thy-1	CD34	7070	947	Gene	Gene	Lin|compound|START_ENTITY Lin|compound|END_ENTITY	Thrombopoietin , kit ligand , and flk2/flt3 _ ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34 + Thy-1 + Lin - cells with preserved ability to engraft SCID-hu bone .
9590653	0	Thy-1	70,75	CD34	65,69	Thy-1	CD34	7070	947	Gene	Gene	blood|compound|START_ENTITY blood|compound|END_ENTITY	A neutralizing anti-TGF-beta1 antibody promotes proliferation of CD34 + Thy-1 + peripheral blood progenitors and increases the number of transduced progenitors .
10064055	0	Thy-1	26,31	CD4	44,47	Thy-1	CD4	7070	920	Gene	Gene	antigens|compound|START_ENTITY antigens|nmod|+ +|compound|END_ENTITY	Spontaneous clustering of Thy-1 antigens on CD4 + CD8 + thymocytes lacking TCR engagement by MHC/peptide complexes .
1673982	0	Thy-1	45,50	CD4	75,78	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY triple|nsubj|+ triple|dobj|cells cells|appos|- -|dep|- -|compound|END_ENTITY	Distinct subsets of accessory cells activate Thy-1 + triple negative -LRB- CD3 - , CD4 - , CD8 - -RRB- cells and Th-1 delayed-type_hypersensitivity effector T cells .
1682394	0	Thy-1	128,133	CD4	135,138	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Resolution of primary murine listeriosis and acquired resistance to lethal secondary infection can be mediated predominantly by Thy-1 + CD4 - CD8 - cells .
1972943	0	Thy-1	61,66	CD4	55,58	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	The pineal neurohormone melatonin_stimulates activated CD4 + , Thy-1 + cells to release opioid agonist -LRB- s -RRB- with immunoenhancing and anti-stress properties .
1980114	0	Thy-1	54,59	CD4	33,36	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY cells|acl|lacking cells|compound|END_ENTITY	A unique subset of normal murine CD4 + T cells lacking Thy-1 is expanded in a murine retrovirus-induced immunodeficiency_syndrome , MAIDS .
21519344	0	Thy-1	57,62	CD4	13,16	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY cells|dep|stimulation Induction|nmod|cells Induction|nmod|CD25 CD25|compound|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
21519344	0	Thy-1	57,62	CD4	78,81	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Induction of CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- Foxp3 -LRB- - -RRB- regulatory T cells by Thy-1 stimulation of CD4 -LRB- + -RRB- T cells .
2478617	0	Thy-1	19,24	CD4	51,54	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	cell|compound|START_ENTITY double-negative|nsubj|cell double-negative|appos|- -|compound|END_ENTITY	The DTH-initiating Thy-1 + cell is double-negative -LRB- CD4 - , CD8 - -RRB- and CD3 - , and expresses IL-3 receptors , but no IL-2 receptors .
7507599	0	Thy-1	44,49	CD4	23,26	Thy-1	CD4	21838(Tax:10090)	12504(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY dynamics|acl|lacking dynamics|nmod|cells cells|compound|END_ENTITY	Population dynamics of CD4 + T cells lacking Thy-1 in murine retrovirus-induced immunodeficiency_syndrome -LRB- MAIDS -RRB- .
7547688	0	Thy-1	26,31	CD4	109,112	Thy-1	CD4	7070	920	Gene	Gene	activation|nmod|START_ENTITY associated|nsubjpass|activation associated|nmod|subset subset|nmod|cells cells|nummod|END_ENTITY	T cell activation through Thy-1 is associated with the expression of a surface protein -LRB- p100 -RRB- on a subset of CD4 cells .
10064055	0	Thy-1	26,31	CD8	49,52	Thy-1	CD8	7070	925	Gene	Gene	antigens|compound|START_ENTITY antigens|nmod|+ +|compound|END_ENTITY	Spontaneous clustering of Thy-1 antigens on CD4 + CD8 + thymocytes lacking TCR engagement by MHC/peptide complexes .
25536077	0	Thy-1	24,29	CD90	18,22	Thy-1	CD90	7070	7070	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of CD90 -LRB- Thy-1 -RRB- in Pancreatic_Adenocarcinoma Present in the Tumor Microenvironment .
7540889	0	Thy-1	20,25	CDw90	27,32	Thy-1	CDw90	7070	7070	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Characterization of Thy-1 -LRB- CDw90 -RRB- expression in CD34 + acute_leukemia .
9028155	0	Thy-1	8,13	CDw90	1,6	Thy-1	CDw90	7070	7070	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	-LSB- CDw90 -LRB- Thy-1 -RRB- expression on CD34 positive cells in peripheral blood stem cell harvest -RSB- .
1973079	0	Thy-1	28,33	IL-4	48,52	Thy-1	IL-4	21838(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of murine B cell Thy-1 expression by IL-4 , IFN-gamma , and CD4 + T cell subsets .
7495757	0	Thy-1	36,41	IL-4	73,77	Thy-1	IL-4	21838(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression lymphocytes|nsubj|regulation lymphocytes|nmod|END_ENTITY	Positive and negative regulation of Thy-1 expression on B lymphocytes by IL-4 .
9056477	0	Thy-1	29,34	Interleukin-1alpha	0,18	Thy-1	Interleukin-1alpha	24832(Tax:10116)	24493(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-1alpha regulates Thy-1 expression on rat vascular endothelial cells .
2901096	0	Thy-1	31,36	Interleukin_4	0,13	Thy-1	Interleukin 4	21838(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_4 induces membrane Thy-1 expression on normal murine B cells .
2879865	1	Thy-1	137,142	Lyt-1	143,148	Thy-1	Lyt-1	21838(Tax:10090)	12507(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	I. Induction of a nylon-adherent , Thy-1 + Lyt-1 +2 - suppressor cell .
2888223	1	Thy-1	68,73	Lyt-1	75,80	Thy-1	Lyt-1	21838(Tax:10090)	12507(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|amod|END_ENTITY	Destruction of a Thy-1 + Lyt-1 +2 - spleen cell implicated in the expression of hybrid resistance .
16453742	0	Thy-1	30,35	Nerve_growth_factor	0,19	Thy-1	Nerve growth factor	24832(Tax:10116)	310738(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Nerve_growth_factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells .
22268140	0	Thy-1	0,5	PPARy	22,27	Thy-1	PPARy	7070	5468	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Thy-1 signals through PPARy to promote lipofibroblast differentiation in the developing lung .
10634171	0	Thy-1	106,111	Sca-1	98,103	Thy-1	Sca-1	21838(Tax:10090)	110454(Tax:10090)	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
9464827	0	Thy-1	43,48	Syk	24,27	Thy-1	Syk	24832(Tax:10116)	25155(Tax:10116)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic_leukemia cells .
2726770	0	Thy-1	70,75	T-cell_receptor_gamma-chain	21,48	Thy-1	T-cell receptor gamma-chain	21838(Tax:10090)	110067(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Limited diversity of T-cell_receptor_gamma-chain expression of murine Thy-1 + dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody .
2885757	0	Thy-1	67,72	T-cell_receptor_gamma-chain	14,41	Thy-1	T-cell receptor gamma-chain	21838(Tax:10090)	110067(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of T-cell_receptor_gamma-chain RNA expression in murine Thy-1 + dendritic epidermal cells .
7908190	0	Thy-1	49,54	glycosylphosphatidylinositol-specific_phospholipase_D	64,117	Thy-1	glycosylphosphatidylinositol-specific phospholipase D	21838(Tax:10090)	14756(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nsubj|release	Saponin-induced release of cell-surface-anchored Thy-1 by serum glycosylphosphatidylinositol-specific_phospholipase_D .
1976521	0	Thy-1	50,55	interleukin_1_alpha	115,134	Thy-1	interleukin 1 alpha	21838(Tax:10090)	16175(Tax:10090)	Gene	Gene	+|compound|START_ENTITY interleukin_1_alpha|nmod|+ expression|nmod|interleukin_1_alpha expression|dep|enhancement enhancement|nmod|production production|amod|END_ENTITY	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
1976521	0	Thy-1	50,55	interleukin_1_alpha	27,46	Thy-1	interleukin 1 alpha	21838(Tax:10090)	16175(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|nmod|+	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
18389476	0	Thy-1	6,11	matrix_metalloproteinase-9	33,59	Thy-1	matrix metalloproteinase-9	7070	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Human Thy-1 induces secretion of matrix_metalloproteinase-9 and CXCL8 from human neutrophils .
8104794	0	Thy-1	123,128	p56lck	48,54	Thy-1	p56lck	24832(Tax:10116)	313050(Tax:10116)	Gene	Gene	kinases|nmod|START_ENTITY kinases|dobj|END_ENTITY	The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl_phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation .
6145315	0	Thy-1_antigen	155,168	H-2	104,107	Thy-1 antigen	H-2	21838(Tax:10090)	111364(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Productive murine leukemia virus -LRB- MuLV -RRB- infection of EL4 T-lymphoblastoid cells : selective elevation of H-2 surface expression and possible association of Thy-1_antigen with viruses .
23846855	0	Thy1	89,93	CD34	84,88	Thy1	CD34	7070	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	3-methylcholanthrene induces neurotoxicity in developing neurons derived from human CD34 + Thy1 + stem cells by activation of aryl_hydrocarbon_receptor .
17952444	0	Thy1	8,12	CD90	14,18	Thy1	CD90	7070	7070	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lack of Thy1 -LRB- CD90 -RRB- expression in neuroblastomas is correlated with impaired survival .
18676775	0	Thy1	0,4	FasL	18,22	Thy1	FasL	7070	356	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Thy1 up-regulates FasL expression in lung myofibroblasts via Src family kinases .
8879216	0	Thy1	101,105	IL-7R	94,99	Thy1	IL-7R	21838(Tax:10090)	16197(Tax:10090)	Gene	Gene	progenitors|compound|START_ENTITY progenitors|compound|END_ENTITY	Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit + IL-7R + Thy1 + lympho-hemopoietic progenitors develop .
8879216	0	Thy1	101,105	c-kit	87,92	Thy1	c-kit	21838(Tax:10090)	16590(Tax:10090)	Gene	Gene	progenitors|compound|START_ENTITY progenitors|amod|END_ENTITY	Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit + IL-7R + Thy1 + lympho-hemopoietic progenitors develop .
22838633	0	Thymic_Stromal_Lymphopoietin_Receptor	23,60	TSLPR	62,67	Thymic Stromal Lymphopoietin Receptor	TSLPR	64109	64109	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	IL-3 and TNFa increase Thymic_Stromal_Lymphopoietin_Receptor -LRB- TSLPR -RRB- expression on eosinophils and enhance TSLP-stimulated degranulation .
24910175	0	Thymic_stromal_lymphopoietin	0,28	IL-23	76,81	Thymic stromal lymphopoietin	IL-23	85480	51561	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Thymic_stromal_lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis .
20483734	0	Thymic_stromal_lymphopoietin	0,28	IL-6	47,51	Thymic stromal lymphopoietin	IL-6	85480	3569	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Thymic_stromal_lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells : role of MAPKs -LRB- ERK1/2 , p38 , and JNK -RRB- and STAT3 pathways .
3022474	0	Thymidine_kinase	0,16	TK	18,20	Thymidine kinase	TK	24271467	24271467	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Thymidine_kinase -LRB- TK -RRB- activity in herpes_simplex_virus_type_1 recombinants that carry insertions affecting regulation of the TK gene .
18359286	0	Thymidine_phosphorylase	0,23	BNIP3	72,77	Thymidine phosphorylase	BNIP3	1890	664	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	Thymidine_phosphorylase inhibits the expression of proapoptotic protein BNIP3 .
24574215	0	Thymidine_phosphorylase	0,23	CXCL10	52,58	Thymidine phosphorylase	CXCL10	1890	3627	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Thymidine_phosphorylase regulates the expression of CXCL10 in rheumatoid_arthritis fibroblast-like synoviocytes .
8407287	0	Thymosin_beta_4	0,15	granulocyte-macrophage_colony-stimulating_factor	38,86	Thymosin beta 4	granulocyte-macrophage colony-stimulating factor	19241(Tax:10090)	1437	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Thymosin_beta_4 synergizes with human granulocyte-macrophage_colony-stimulating_factor in maintaining bone marrow proliferation .
14592829	0	Thymosin_beta_4	0,15	plasminogen_activator_inhibitor_1	41,74	Thymosin beta 4	plasminogen activator inhibitor 1	7114	5054	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Thymosin_beta_4 induces the synthesis of plasminogen_activator_inhibitor_1 in cultured endothelial cells and increases its extracellular expression .
16859899	0	Thymus_and_activation_regulated_chemokine	0,41	CCL17	49,54	Thymus and activation regulated chemokine	CCL17	6361	6361	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	Thymus_and_activation_regulated_chemokine -LRB- TARC -RRB- / CCL17 and skin_diseases .
3123067	0	Thyroid-stimulating_hormone_and_prolactin	0,41	thyrotropin-releasing_hormone	55,84	Thyroid-stimulating hormone and prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Thyroid-stimulating_hormone_and_prolactin responses to thyrotropin-releasing_hormone in common migraine .
20615868	0	Thyroid_hormone_receptor_beta	0,29	carbohydrate-response_element-binding_protein	75,120	Thyroid hormone receptor beta	carbohydrate-response element-binding protein	21834(Tax:10090)	58805(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	Thyroid_hormone_receptor_beta -LRB- TRbeta -RRB- and liver X receptor -LRB- LXR -RRB- regulate carbohydrate-response_element-binding_protein -LRB- ChREBP -RRB- expression in a tissue-selective manner .
10632746	0	Thyroid_transcription_factor-1	0,30	surfactant_proteins_A_and_B	142,169	Thyroid transcription factor-1	surfactant proteins A and B	7080	6439;653509	Gene	Gene	marker|nsubj|START_ENTITY marker|acl|END_ENTITY	Thyroid_transcription_factor-1 is the superior immunohistochemical marker for pulmonary_adenocarcinomas and large_cell_carcinomas compared to surfactant_proteins_A_and_B .
3130285	0	Thyrotrophin-releasing_hormone	0,30	growth_hormone	39,53	Thyrotrophin-releasing hormone	growth hormone	7200	2688	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Thyrotrophin-releasing_hormone induces growth_hormone secretion in adult hypothyroid fowl .
3097590	0	Thyrotropin-releasing_hormone	0,29	TRH	31,34	Thyrotropin-releasing hormone	TRH	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- degradation in NIH : N mouse cerebral cortex and spinal cord .
6265032	0	Thyrotropin-releasing_hormone	0,29	TRH	31,34	Thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- content of rat striatum : modification by drugs and lesions .
8299576	0	Thyrotropin-releasing_hormone	0,29	TRH	31,34	Thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- gene expression in the anterior pituitary .
10976912	0	Thyrotropin-releasing_hormone	0,29	epidermal_growth_factor_receptor	64,96	Thyrotropin-releasing hormone	epidermal growth factor receptor	25569(Tax:10116)	24329(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Thyrotropin-releasing_hormone stimulates phosphorylation of the epidermal_growth_factor_receptor in GH3 pituitary cells .
1345575	0	Thyrotropin-releasing_hormone	0,29	growth_hormone	54,68	Thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	suppress|nsubj|START_ENTITY suppress|dobj|response response|amod|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- does not suppress growth_hormone response to L-dopa in insulin-dependent diabetes_mellitus .
21554653	0	Thyrotropin-releasing_hormone	0,29	growth_hormone	39,53	Thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Thyrotropin-releasing_hormone mediates growth_hormone release induced by milk and nursing in neonatal rats .
3935480	0	Thyrotropin-releasing_hormone	0,29	growth_hormone	74,88	Thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|secretion secretion|compound|END_ENTITY	Thyrotropin-releasing_hormone does not inhibit lysine_vasopressin-induced growth_hormone secretion in normal men .
4364640	0	Thyrotropin-releasing_hormone	0,29	growth_hormone	73,87	Thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Thyrotropin-releasing_hormone stimulation and somatostatin inhibition of growth_hormone secretion from perfused rat adenohypophyses .
7808594	0	Thyrotropin-releasing_hormone	0,29	growth_hormone	54,68	Thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|dep|function function|nmod|neurons neurons|amod|END_ENTITY	Thyrotropin-releasing_hormone : inhibitory function on growth_hormone through both somatostatin and growth_hormone-releasing factor neurons .
8032680	0	Thyrotropin-releasing_hormone	0,29	jun_B	53,58	Thyrotropin-releasing hormone	jun B	25569(Tax:10116)	24517(Tax:10116)	Gene	Gene	stimulates|amod|START_ENTITY stimulates|nmod|END_ENTITY	Thyrotropin-releasing_hormone stimulates in parallel jun_B and c-fos messenger ribonucleic acids in GH3B6 pituitary cells : comparison with PRL secretion .
11882596	0	Thyrotropin-releasing_hormone	0,29	leptin	40,46	Thyrotropin-releasing hormone	leptin	25569(Tax:10116)	25608(Tax:10116)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Thyrotropin-releasing_hormone decreases leptin and mediates the leptin-induced pressor effect .
20302576	0	Thyrotropin-releasing_hormone	0,29	prolactin	68,77	Thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Thyrotropin-releasing_hormone and oestrogen differentially regulate prolactin and prolactin_receptor expression in female human skin and hair follicles in vitro .
3096691	0	Thyrotropin-releasing_hormone	0,29	prolactin	45,54	Thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|compound|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin secretion is coordinately but not synergistically regulated by an elevation of cytoplasmic calcium and 1,2-diacylglycerol .
3925367	0	Thyrotropin-releasing_hormone	0,29	prolactin	53,62	Thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Thyrotropin-releasing_hormone provocative release of prolactin and thyrotropin in acute head_injury .
6418746	1	Thyrotropin-releasing_hormone	51,80	prolactin	126,135	Thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Thyrotropin-releasing_hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein .
6787084	0	Thyrotropin-releasing_hormone	0,29	prolactin	45,54	Thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|release release|compound|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin release from clonal rat pituitary cells : evidence for action independent of extracellular calcium .
6796963	0	Thyrotropin-releasing_hormone	0,29	prolactin	97,106	Thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	exerts|nsubj|START_ENTITY exerts|advcl|increase increase|dobj|production production|nmod|transcript transcript|compound|END_ENTITY	Thyrotropin-releasing_hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA transcript .
8386115	0	Thyrotropin-releasing_hormone	0,29	prolactin	71,80	Thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|compound|END_ENTITY	Thyrotropin-releasing_hormone and epidermal_growth_factor induce human prolactin expression via identical multiple cis elements .
11566956	0	Thyrotropin-releasing_hormone_receptor	0,38	TRHR	40,44	Thyrotropin-releasing hormone receptor	TRHR	7201	7201	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Thyrotropin-releasing_hormone_receptor -LRB- TRHR -RRB- gene is associated with essential hypertension .
25411513	0	Thyrotropin_Receptor	0,20	Interleukin-8	38,51	Thyrotropin Receptor	Interleukin-8	7253	3576	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Thyrotropin_Receptor and CD40 Mediate Interleukin-8 Expression in Fibrocytes : Implications for Thyroid-Associated_Ophthalmopathy -LRB- An American Ophthalmological Society Thesis -RRB- .
21302295	0	Tiam1	0,5	14-3-3	47,53	Tiam1	14-3-3	7074	10971	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Tiam1 is recruited to b1-integrin complexes by 14-3-3 where it mediates integrin-induced Rac1 activation and motility .
20215110	0	Tiam1	21,26	CADM1	0,5	Tiam1	CADM1	7074	23705	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell_leukemia virus type I-transformed cells and adult T-cell_leukemia cells .
26078008	0	Tiam1	38,43	Cdk1	0,4	Tiam1	Cdk1	7074	983	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation .
24112471	0	Tiam1	47,52	EphA2	0,5	Tiam1	EphA2	7074	1969	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	EphA2 signaling following endocytosis : role of Tiam1 .
24551096	0	Tiam1	72,77	MiR-141	0,7	Tiam1	MiR-141	7074	406933	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	MiR-141 suppresses the migration and invasion of HCC cells by targeting Tiam1 .
15723052	0	Tiam1	71,76	Par-3	0,5	Tiam1	Par-3	7074	56288	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Par-3 controls tight junction assembly through the Rac exchange factor Tiam1 .
26084985	0	Tiam1	72,77	Par3	0,4	Tiam1	Par3	7074	56288	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Par3 regulates invasion of pancreatic_cancer cells via interaction with Tiam1 .
16203995	0	Tiam1	42,47	Rac1	20,24	Tiam1	Rac1	7074	5879	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Ras activation of a Rac1 exchange factor , Tiam1 , mediates neurotrophin-3-induced Schwann cell migration .
17440041	0	Tiam1	44,49	Rac1	4,8	Tiam1	Rac1	7074	5879	Gene	Gene	development|compound|START_ENTITY development|amod|END_ENTITY	The Rac1 guanine_nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development .
22761450	0	Tid1	78,82	Dmc1	25,29	Tid1	Dmc1	852365(Tax:4932)	856926(Tax:4932)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Saccharomyces_cerevisiae Dmc1 and Rad51 proteins preferentially function with Tid1 and Rad54 proteins , respectively , to promote DNA strand invasion during genetic recombination .
26055714	0	Tid1	0,4	Tid56	61,66	Tid1	Tid56	9093	48844(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Tid1 , the mammalian homologue of Drosophila_tumor suppressor Tid56 , mediates macroautophagy by interacting with Beclin1-containing autophagy protein complex .
26055714	0	Tid56	61,66	Tid1	0,4	Tid56	Tid1	48844(Tax:7227)	9093	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Tid1 , the mammalian homologue of Drosophila_tumor suppressor Tid56 , mediates macroautophagy by interacting with Beclin1-containing autophagy protein complex .
9233584	0	Tie	12,15	receptor_tyrosine_kinase	16,40	Tie	receptor tyrosine kinase	7075	5979	Gene	Gene	Analysis|nmod|START_ENTITY END_ENTITY|nsubj|Analysis	Analysis of Tie receptor_tyrosine_kinase in haemopoietic progenitor and leukaemia cells .
10949653	0	Tie-1	0,5	SHP2	59,63	Tie-1	SHP2	7075	5781	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Tie-1 receptor_tyrosine_kinase endodomain interaction with SHP2 : potential signalling mechanisms and roles in angiogenesis .
10949653	0	Tie-1	0,5	receptor_tyrosine_kinase	6,30	Tie-1	receptor tyrosine kinase	7075	5979	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Tie-1 receptor_tyrosine_kinase endodomain interaction with SHP2 : potential signalling mechanisms and roles in angiogenesis .
25312939	0	Tie-2	29,34	Angiopoietin-2	14,28	Tie-2	Angiopoietin-2	7010	285	Gene	Gene	axis|compound|START_ENTITY axis|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the Angiopoietin-2 / Tie-2 axis in conjunction with VEGF signal interference .
12679933	0	Tie-2	19,24	IL-11	0,5	Tie-2	IL-11	89804(Tax:10116)	171040(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-11 up-regulates Tie-2 expression during the healing of gastric_ulcers in rats .
21723278	0	Tie-2	120,125	PECAM1	174,180	Tie-2	PECAM1	21687(Tax:10090)	18613(Tax:10090)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Angiopoietins-1_and _ -2 play opposing roles in endothelial sprouting of embryoid bodies in 3D culture and their receptor Tie-2 associates with the cell-cell adhesion molecule PECAM1 .
26642851	0	Tie-2	69,74	VE-cadherin	93,104	Tie-2	VE-cadherin	7010	1003	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin .
11866538	0	Tie-2	49,54	Vascular_endothelial_growth_factor	0,34	Tie-2	Vascular endothelial growth factor	7010	7422	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor modulates the Tie-2 : Tie-1 receptor complex .
12875855	0	Tie-2	47,52	Vascular_endothelial_growth_factor	0,34	Tie-2	Vascular endothelial growth factor	7010	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Vascular_endothelial_growth_factor and soluble Tie-2 receptor in colorectal_cancer : associations with disease recurrence .
26463042	0	Tie-2	80,85	angiopoietin-1	46,60	Tie-2	angiopoietin-1	7010	284	Gene	Gene	ratios|compound|START_ENTITY ratios|dep|END_ENTITY	Prognostic significance of the angiopoietin-2 / angiopoietin-1 and angiopoietin-1 / Tie-2 ratios for early_sepsis in an emergency_department .
17513791	0	Tie-2	14,19	angiopoietin-2	62,76	Tie-2	angiopoietin-2	7010	285	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Tie-2 by human monocytes and their responses to angiopoietin-2 .
26463042	0	Tie-2	80,85	angiopoietin-2	31,45	Tie-2	angiopoietin-2	7010	285	Gene	Gene	ratios|compound|START_ENTITY ratios|amod|END_ENTITY	Prognostic significance of the angiopoietin-2 / angiopoietin-1 and angiopoietin-1 / Tie-2 ratios for early_sepsis in an emergency_department .
15056293	0	Tie-2	131,136	occludin	61,69	Tie-2	occludin	89804(Tax:10116)	83497(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|dobj|expression expression|compound|END_ENTITY	A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro .
22235284	0	Tie1	56,60	VEGF	99,103	Tie1	VEGF	7075	7422	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFa and regulates angiopoietin signalling .
23065888	0	Tie2	15,19	Angiopoietin-2	0,14	Tie2	Angiopoietin-2	7010	285	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Angiopoietin-2 / Tie2 signaling involved in TNF-a induced peritoneal angiogenesis .
23149917	0	Tie2	30,34	Angiopoietin-2	0,14	Tie2	Angiopoietin-2	7010	285	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Angiopoietin-2 functions as a Tie2 agonist in tumor models , where it limits the effects of VEGF inhibition .
9204896	0	Tie2	41,45	Angiopoietin-2	0,14	Tie2	Angiopoietin-2	21687(Tax:10090)	11601(Tax:10090)	Gene	Gene	antagonist|nmod|START_ENTITY angiogenesis|nsubj|antagonist angiogenesis|advmod|END_ENTITY	Angiopoietin-2 , a natural antagonist for Tie2 that disrupts in vivo angiogenesis .
20973951	0	Tie2	37,41	Grb14	28,33	Tie2	Grb14	7010	2888	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Grb14 by Tie2 .
26344773	0	Tie2	100,104	Tip	108,111	Tie2	Tip	7010	81533	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells .
17901375	0	Tie2	13,17	VEGF	0,4	Tie2	VEGF	7010	7422	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling .
17901375	0	Tie2	93,97	VEGF	0,4	Tie2	VEGF	7010	7422	Gene	Gene	shedding|nmod|START_ENTITY Tie2|acl|shedding induces|dobj|Tie2 induces|nsubj|END_ENTITY	VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling .
21525162	0	Tie2	30,34	VEGF	124,128	Tie2	VEGF	7010	7422	Gene	Gene	levels|amod|START_ENTITY circulating|dobj|levels Decreased|xcomp|circulating Decreased|nsubj|result result|appos|END_ENTITY	Decreased circulating soluble Tie2 levels in preeclampsia may result from inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- signaling .
23149917	0	Tie2	30,34	VEGF	91,95	Tie2	VEGF	7010	7422	Gene	Gene	functions|nmod|START_ENTITY agonist|nsubj|functions agonist|advcl|limits limits|dobj|effects effects|nmod|inhibition inhibition|compound|END_ENTITY	Angiopoietin-2 functions as a Tie2 agonist in tumor models , where it limits the effects of VEGF inhibition .
19424712	0	Tie2	13,17	angiopoietin-1	67,81	Tie2	angiopoietin-1	7010	284	Gene	Gene	localizes|nsubj|START_ENTITY localizes|nmod|END_ENTITY	Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1 .
11166279	0	Tie2	110,114	angiopoietin-2	21,35	Tie2	angiopoietin-2	7010	285	Gene	Gene	activation|nmod|START_ENTITY associated|nmod|activation associated|nsubjpass|action action|nmod|model model|amod|END_ENTITY	Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2 .
11733376	0	Tie2	10,14	angiopoietin-2	81,95	Tie2	angiopoietin-2	7010	285	Gene	Gene	response|compound|START_ENTITY response|nmod|expression expression|amod|END_ENTITY	Increased Tie2 expression , enhanced response to angiopoietin-1 , and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells .
15893672	0	Tie2	99,103	angiopoietin-2	17,31	Tie2	angiopoietin-2	7010	285	Gene	Gene	recognition|amod|START_ENTITY involved|nmod|recognition involved|nsubj|Structure Structure|nmod|domain domain|amod|END_ENTITY	Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition .
19339208	0	Tie2	76,80	angiopoietin-2	11,25	Tie2	angiopoietin-2	7010	285	Gene	Gene	receptor|amod|START_ENTITY activates|dobj|receptor activates|nsubj|variant variant|amod|END_ENTITY	A designed angiopoietin-2 variant , pentameric COMP-Ang2 , strongly activates Tie2 receptor and stimulates angiogenesis .
22342979	0	Tie2	19,23	angiopoietin-2	42,56	Tie2	angiopoietin-2	7010	285	Gene	Gene	role|amod|START_ENTITY role|nmod|cells cells|amod|END_ENTITY	Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells .
14697507	0	Tieg	59,63	Tieg3	32,37	Tieg	Tieg3	21847(Tax:10090)	194655(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Gene structure and evolution of Tieg3 , a new member of the Tieg family of proteins .
14697507	0	Tieg3	32,37	Tieg	59,63	Tieg3	Tieg	194655(Tax:10090)	21847(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Gene structure and evolution of Tieg3 , a new member of the Tieg family of proteins .
18026104	0	Tif1alpha	16,25	Trim24	8,14	Tif1alpha	Trim24	21848(Tax:10090)	21848(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Loss of Trim24 -LRB- Tif1alpha -RRB- gene function confers oncogenic activity to retinoic_acid_receptor_alpha .
23161469	0	Tim-3	91,96	CD25	36,40	Tim-3	CD25	84868	3559	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ +|nmod|pathway +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
22438246	0	Tim-3	22,27	CD4	52,55	Tim-3	CD4	84868	920	Gene	Gene	renders|amod|START_ENTITY activated|nsubj|renders activated|xcomp|susceptible susceptible|nsubj|cells cells|compound|END_ENTITY	Galectin-9 binding to Tim-3 renders activated human CD4 + T cells less susceptible to HIV-1_infection .
23161469	0	Tim-3	91,96	CD4	31,34	Tim-3	CD4	84868	920	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ +|nmod|pathway +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
26064278	0	Tim-3	16,21	CD4	25,28	Tim-3	CD4	84868	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Upregulation of Tim-3 on CD4 -LRB- + -RRB- T cells is associated with Th1/Th2 imbalance in patients with allergic_asthma .
26930930	0	Tim-3	15,20	CD4	41,44	Tim-3	CD4	84868	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	-LSB- Expression of Tim-3 on peripheral blood CD4 + T cells and its correlation with liver function damage parameters in advanced schistosomiasis patients -RSB- .
18353298	0	Tim-3	4,9	CD8	49,52	Tim-3	CD8	84868	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|cell cell|compound|END_ENTITY	The Tim-3 ligand galectin-9 negatively regulates CD8 + alloreactive T cell and prolongs survival of skin graft .
20679213	0	Tim-3	15,20	CD8	33,36	Tim-3	CD8	84868	925	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|exhaustion exhaustion|compound|END_ENTITY	Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral_infection .
21382414	0	Tim-3	23,28	CD8	32,35	Tim-3	CD8	84868	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary_tuberculosis .
21385853	0	Tim-3	16,21	CD8	44,47	Tim-3	CD8	84868	925	Gene	Gene	Coexpression|nmod|START_ENTITY identifies|nsubj|Coexpression identifies|dobj|phenotype phenotype|compound|END_ENTITY	Coexpression of Tim-3 and PD-1 identifies a CD8 + T-cell exhaustion phenotype in mice with disseminated acute_myelogenous_leukemia .
21541358	0	Tim-3	55,60	CD8	20,23	Tim-3	CD8	84868	925	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|cells cells|nummod|END_ENTITY	HTLV-1 tax specific CD8 + T cells express low levels of Tim-3 in HTLV-1_infection : implications for progression to neurological_complications .
22539292	0	Tim-3	12,17	CD8	56,59	Tim-3	CD8	84868	925	Gene	Gene	Blockade|nmod|START_ENTITY restores|nsubj|Blockade restores|dobj|response response|compound|END_ENTITY	Blockade of Tim-3 signaling restores the virus-specific CD8 T-cell response in patients with chronic hepatitis_B .
22792231	0	Tim-3	0,5	CD8	53,56	Tim-3	CD8	84868	925	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|cells cells|compound|END_ENTITY	Tim-3 negatively regulates cytotoxicity in exhausted CD8 + T cells in HIV_infection .
26141233	0	Tim-3	103,108	CD8	56,59	Tim-3	CD8	84868	925	Gene	Gene	regulation|nmod|START_ENTITY responses|nmod|regulation responses|compound|END_ENTITY	IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast_cancer .
23161469	0	Tim-3	91,96	Gal-9	97,102	Tim-3	Gal-9	84868	3965	Gene	Gene	/|amod|START_ENTITY pathway|amod|/ pathway|compound|END_ENTITY	HCV-infected hepatocytes drive CD4 + CD25 + Foxp3 + regulatory T-cell development through the Tim-3 / Gal-9 pathway .
25135732	0	Tim-3	27,32	Gal-9	33,38	Tim-3	Gal-9	84868	3965	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Up-regulated expression of Tim-3 / Gal-9 at maternal-fetal interface in pregnant woman with recurrent_spontaneous_abortion .
26342682	0	Tim-3	20,25	Gal-9	26,31	Tim-3	Gal-9	84868	3965	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|dep|pathway pathway|compound|END_ENTITY	Upregulation of the Tim-3 / Gal-9 pathway and correlation with the development of preeclampsia .
19017954	0	Tim-3	21,26	Galectin-9	0,10	Tim-3	Galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	+|amod|START_ENTITY cells|amod|+ increases|dobj|cells increases|nsubj|END_ENTITY	Galectin-9 increases Tim-3 + dendritic cells and CD8 + T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions .
21187321	0	Tim-3	61,66	Galectin-9	0,10	Tim-3	Galectin-9	84868	3965	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Galectin-9 regulates T helper cell function independently of Tim-3 .
22438246	0	Tim-3	22,27	Galectin-9	0,10	Tim-3	Galectin-9	84868	3965	Gene	Gene	renders|amod|START_ENTITY renders|amod|END_ENTITY	Galectin-9 binding to Tim-3 renders activated human CD4 + T cells less susceptible to HIV-1_infection .
22685601	0	Tim-3	45,50	Galectin-9	0,10	Tim-3	Galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	independent|amod|START_ENTITY mechanism|amod|independent signaling|nmod|mechanism CD40|acl|signaling controls|dobj|CD40 controls|nsubj|END_ENTITY	Galectin-9 controls CD40 signaling through a Tim-3 independent mechanism and redirects the cytokine profile of pathogenic T cells in autoimmunity .
23585851	0	Tim-3	120,125	Galectin-9	0,10	Tim-3	Galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	inducing|nmod|START_ENTITY ameliorates|advcl|inducing ameliorates|nsubj|END_ENTITY	Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3 .
25578313	0	Tim-3	15,20	Galectin-9	4,14	Tim-3	Galectin-9	84868	3965	Gene	Gene	involved|nsubjpass|START_ENTITY END_ENTITY|parataxis|involved	The Galectin-9 / Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy .
26789128	0	Tim-3	0,5	Galectin-9	107,117	Tim-3	Galectin-9	84868	3965	Gene	Gene	Upregulated|nsubjpass|START_ENTITY Upregulated|nmod|Trophoblast Trophoblast|nmod|Pathway Pathway|compound|END_ENTITY	Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway .
21807895	0	Tim-3	38,43	T-cell_receptor	47,62	Tim-3	T-cell receptor	84868	6962	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Phosphotyrosine-dependent coupling of Tim-3 to T-cell_receptor signaling pathways .
19913460	0	Tim-3	34,39	T_cell_Ig_Mucin-3	15,32	Tim-3	T cell Ig Mucin-3	171285(Tax:10090)	171285(Tax:10090)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of T_cell_Ig_Mucin-3 -LRB- Tim-3 -RRB- in the negative regulation of inflammatory_bowel_disease .
16286920	0	Tim-3	4,9	galectin-9	17,27	Tim-3	galectin-9	84868	3965	Gene	Gene	ligand|nsubj|START_ENTITY ligand|xcomp|END_ENTITY	The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity .
17069754	0	Tim-3	31,36	galectin-9	86,96	Tim-3	galectin-9	84868	3965	Gene	Gene	tyrosine|nmod|START_ENTITY phosphorylated|nsubjpass|tyrosine phosphorylated|nmod|END_ENTITY	A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9 .
19100864	0	Tim-3	17,22	galectin-9	31,41	Tim-3	galectin-9	84868	3965	Gene	Gene	Detection|nmod|START_ENTITY Detection|amod|END_ENTITY	Detection of the Tim-3 ligand , galectin-9 , inside the allograft during a rejection episode .
19234217	0	Tim-3	8,13	galectin-9	14,24	Tim-3	galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY /|nsubj|Role /|dobj|interaction interaction|amod|END_ENTITY	Role of Tim-3 / galectin-9 inhibitory interaction in viral-induced immunopathology : shifting the balance toward regulators .
20574007	0	Tim-3	0,5	galectin-9	6,16	Tim-3	galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	START_ENTITY|dep|pathway pathway|amod|END_ENTITY	Tim-3 / galectin-9 pathway : regulation of Th1 immunity through promotion of CD11b + Ly-6G + myeloid cells .
22323453	0	Tim-3	0,5	galectin-9	114,124	Tim-3	galectin-9	84868	3965	Gene	Gene	receptor|nsubj|START_ENTITY receptor|acl:relcl|enhances enhances|nmod|END_ENTITY	Tim-3 is an inducible human natural killer cell receptor that enhances interferon_gamma production in response to galectin-9 .
22505239	0	Tim-3	0,5	galectin-9	6,16	Tim-3	galectin-9	84868	3965	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|signaling signaling|amod|END_ENTITY	Tim-3 / galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis_B_virus-associated hepatocellular_carcinoma .
22677125	0	Tim-3	55,60	galectin-9	61,71	Tim-3	galectin-9	84868	3965	Gene	Gene	effects|nmod|START_ENTITY Contrasting|dobj|effects blockade|dep|Contrasting blockade|amod|END_ENTITY	Contrasting acute graft-versus-host disease effects of Tim-3 / galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells .
23112829	0	Tim-3	20,25	galectin-9	26,36	Tim-3	galectin-9	84868	3965	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|dep|pathway pathway|amod|END_ENTITY	Upregulation of the Tim-3 / galectin-9 pathway of T cell exhaustion in chronic hepatitis_B_virus infection .
24333756	0	Tim-3	4,9	galectin-9	10,20	Tim-3	galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|involves involves|nsubj|pathway pathway|amod|END_ENTITY	The Tim-3 / galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis .
24639110	0	Tim-3	12,17	galectin-9	18,28	Tim-3	galectin-9	84868	3965	Gene	Gene	Hypothesis|dep|START_ENTITY Hypothesis|parataxis|stem stem|nsubj|END_ENTITY	Hypothesis : Tim-3 / galectin-9 , a new pathway for leukemia stem cells survival by promoting expansion of myeloid-derived suppressor cells and differentiating into tumor-associated macrophages .
25264706	0	Tim-3	41,46	galectin-9	82,92	Tim-3	galectin-9	363578(Tax:10116)	16859(Tax:10090)	Gene	Gene	osteoclastogenesis|nmod|START_ENTITY Regulation|nmod|osteoclastogenesis Regulation|dep|system system|amod|END_ENTITY	Regulation of osteoclastogenesis through Tim-3 : possible involvement of the Tim-3 / galectin-9 system in the modulation of inflammatory bone_destruction .
25264706	0	Tim-3	76,81	galectin-9	82,92	Tim-3	galectin-9	363578(Tax:10116)	16859(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY Regulation|dep|involvement Regulation|dep|system system|amod|END_ENTITY	Regulation of osteoclastogenesis through Tim-3 : possible involvement of the Tim-3 / galectin-9 system in the modulation of inflammatory bone_destruction .
26494364	0	Tim-3	12,17	galectin-9	18,28	Tim-3	galectin-9	171285(Tax:10090)	16859(Tax:10090)	Gene	Gene	START_ENTITY|dep|expressions expressions|amod|END_ENTITY	Upregulated Tim-3 / galectin-9 expressions in acute_lung_injury in a murine malarial model .
25779220	0	Tim10	28,33	Tim9	14,18	Tim10	Tim9	856395(Tax:4932)	856693(Tax:4932)	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
26182355	0	Tim10	28,33	Tim9	14,18	Tim10	Tim9	856395(Tax:4932)	856693(Tax:4932)	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
25779220	0	Tim10	28,33	Yme1	67,71	Tim10	Yme1	856395(Tax:4932)	856135(Tax:4932)	Gene	Gene	protects|dobj|START_ENTITY protects|nmod|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
26182355	0	Tim10	28,33	Yme1	67,71	Tim10	Yme1	856395(Tax:4932)	856135(Tax:4932)	Gene	Gene	protects|dobj|START_ENTITY protects|nmod|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
9419343	0	Tim44	75,80	translocase_of_inner_mitochondrial_membrane	30,73	Tim44	translocase of inner mitochondrial membrane	10469	10469	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of mammalian translocase_of_inner_mitochondrial_membrane -LRB- Tim44 -RRB- isolated from diabetic_newborn_mouse_kidney .
25779220	0	Tim9	14,18	Tim10	28,33	Tim9	Tim10	856693(Tax:4932)	856395(Tax:4932)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
26182355	0	Tim9	14,18	Tim10	28,33	Tim9	Tim10	856693(Tax:4932)	856395(Tax:4932)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
25779220	0	Tim9	14,18	Yme1	67,71	Tim9	Yme1	856693(Tax:4932)	856135(Tax:4932)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
26182355	0	Tim9	14,18	Yme1	67,71	Tim9	Yme1	856693(Tax:4932)	856135(Tax:4932)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
26344098	0	Timeless	0,8	PARP-1	24,30	Timeless	PARP-1	8914	142	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair .
9891984	0	Timeless1	76,85	timeless	61,69	Timeless1	timeless	33571(Tax:7227)	33571(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of the mammalian homologues of the Drosophila timeless gene , Timeless1 .
10428785	0	Timp-1	141,147	tissue_inhibitor_of_metalloproteinases-1	99,139	Timp-1	tissue inhibitor of metalloproteinases-1	21857(Tax:10090)	21857(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue_inhibitor_of_metalloproteinases-1 -LRB- Timp-1 -RRB- gene .
19551841	0	Timp-2	0,6	MT1-MMP	29,36	Timp-2	MT1-MMP	7077	4323	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells .
10931526	0	Timp-3	55,61	tissue_inhibitor_of_metalloproteinase-3	14,53	Timp-3	tissue inhibitor of metalloproteinase-3	25358(Tax:10116)	25358(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Regulation of tissue_inhibitor_of_metalloproteinase-3 -LRB- Timp-3 -RRB- mRNA expression during rat CNS development .
11988080	0	Timp-4	122,128	tissue_inhibitor_of_metalloproteinases-4	80,120	Timp-4	tissue inhibitor of metalloproteinases-4	110595(Tax:10090)	110595(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of an initiator-like element essential for the expression of the tissue_inhibitor_of_metalloproteinases-4 -LRB- Timp-4 -RRB- gene .
23522389	0	Timp1	0,5	beta-1_integrin	21,36	Timp1	beta-1 integrin	7076	3688	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Timp1 interacts with beta-1_integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation .
26297111	0	Timp1	9,14	beta-1_integrin	30,45	Timp1	beta-1 integrin	7076	3688	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Erratum : Timp1 interacts with beta-1_integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation .
9034334	0	Tinman	23,29	D-mef2	0,6	Tinman	D-mef2	42536(Tax:7227)	36032(Tax:7227)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	D-mef2 is a target for Tinman activation during Drosophila heart development .
26344773	0	Tip	108,111	Tie2	100,104	Tip	Tie2	81533	7010	Gene	Gene	Cells|compound|START_ENTITY END_ENTITY|nmod|Cells	The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells .
21139582	0	Tip-1	29,34	ARHGEF16	50,58	Tip-1	ARHGEF16	30851	27237	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16 , which activates Cdc42 .
23822148	0	Tip110	0,6	YB-1	22,26	Tip110	YB-1	9733	4904	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tip110 interacts with YB-1 and regulates each other 's function .
16968708	0	Tip47	78,83	ADFP	90,94	Tip47	ADFP	66905(Tax:10090)	11520(Tax:10090)	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	Functional compensation for adipose_differentiation-related_protein -LRB- ADFP -RRB- by Tip47 in an ADFP null embryonic cell line .
25865756	0	Tip60	72,77	ATF3	27,31	Tip60	ATF3	10524	467	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60 .
26994140	0	Tip60	80,85	ATF3	27,31	Tip60	ATF3	10524	467	Gene	Gene	UV|nmod|START_ENTITY UV|nsubj|Dichotomous Dichotomous|compound|END_ENTITY	The Stress Responsive Gene ATF3 Mediates Dichotomous UV Responses by Regulating Tip60 and p53 .
26464124	0	Tip60	0,5	MT1-MMP	16,23	Tip60	MT1-MMP	10524	4323	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-kB pathway .
11927554	0	Tip60	0,5	Mdm2	56,60	Tip60	Mdm2	10524	4193	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation .
19308289	0	Tip60	21,26	PDCD5	0,5	Tip60	PDCD5	10524	9141	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis .
17996965	0	Tip60	49,54	Rev-erbbeta	28,39	Tip60	Rev-erbbeta	10524	9975	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein_CIII promoter .
19800870	0	Tip60	45,50	UHRF1	0,5	Tip60	UHRF1	10524	29128	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity .
23777805	0	Tip60	39,44	Zinc_finger_protein_668	0,23	Tip60	Zinc finger protein 668	10524	79759	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Zinc_finger_protein_668 interacts with Tip60 to promote H2AX acetylation after DNA damage .
15310756	0	Tip60	39,44	p53	52,55	Tip60	p53	10524	7157	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Role of the histone acetyl transferase Tip60 in the p53 pathway .
21463657	0	Tip60	50,55	p53	28,31	Tip60	p53	10524	7157	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	TRIM29 negatively regulates p53 via inhibition of Tip60 .
23576563	0	Tip60	10,15	p53	41,44	Tip60	p53	10524	7157	Gene	Gene	cofactor|amod|START_ENTITY cofactor|acl:relcl|acetylates acetylates|dobj|END_ENTITY	ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage .
24577093	0	Tipe2	87,92	MicroRNA-21	0,11	Tipe2	MicroRNA-21	79626	406991	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-21 regulates T-cell apoptosis by directly targeting the tumor suppressor gene Tipe2 .
26675253	0	Tissue-Nonspecific_Alkaline_Phosphatase	29,68	TNAP	70,74	Tissue-Nonspecific Alkaline Phosphatase	TNAP	11647(Tax:10090)	11647(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Transgenic Overexpression of Tissue-Nonspecific_Alkaline_Phosphatase -LRB- TNAP -RRB- in Vascular Endothelium Results in Generalized Arterial_Calcification .
23825434	0	Tissue-nonspecific_alkaline_phosphatase	0,39	PAP	62,65	Tissue-nonspecific alkaline phosphatase	PAP	11647(Tax:10090)	56318(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Tissue-nonspecific_alkaline_phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord .
19608750	0	Tissue-type_plasminogen_activator	0,33	MMP-3	64,69	Tissue-type plasminogen activator	MMP-3	18791(Tax:10090)	17392(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Tissue-type_plasminogen_activator -LRB- t-PA -RRB- induces stromelysin-1 -LRB- MMP-3 -RRB- in endothelial cells through activation of lipoprotein_receptor-related_protein .
19608750	0	Tissue-type_plasminogen_activator	0,33	lipoprotein_receptor-related_protein	114,150	Tissue-type plasminogen activator	lipoprotein receptor-related protein	18791(Tax:10090)	16971(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Tissue-type_plasminogen_activator -LRB- t-PA -RRB- induces stromelysin-1 -LRB- MMP-3 -RRB- in endothelial cells through activation of lipoprotein_receptor-related_protein .
25677604	0	Tissue_Factor_Pathway_Inhibitor	20,51	ApoE	179,183	Tissue Factor Pathway Inhibitor	ApoE	7035	348	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Human Tissue_Factor_Pathway_Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage_Migration_Inhibitory_Factor and Attenuates_Atherosclerosis in ApoE - / - Mice .
25677604	0	Tissue_Factor_Pathway_Inhibitor	20,51	Macrophage_Migration_Inhibitory_Factor	106,144	Tissue Factor Pathway Inhibitor	Macrophage Migration Inhibitory Factor	7035	4282	Gene	Gene	START_ENTITY|nmod|Secretion Secretion|nmod|END_ENTITY	Expression of Human Tissue_Factor_Pathway_Inhibitor on Vascular Smooth Muscle Cells Inhibits Secretion of Macrophage_Migration_Inhibitory_Factor and Attenuates_Atherosclerosis in ApoE - / - Mice .
25303460	0	Tissue_Factor_Pathway_Inhibitor	24,55	Thrombin	0,8	Tissue Factor Pathway Inhibitor	Thrombin	7035	2147	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Thrombin Down-Regulates Tissue_Factor_Pathway_Inhibitor Expression in a PI3K/Nuclear Factor-kB-Dependent Manner in Human Pleural Mesothelial Cells .
25627976	0	Tissue_Plasminogen_Activator	86,114	miR340	0,6	Tissue Plasminogen Activator	miR340	100128998	442908	Gene	Gene	Suppresses|nmod|START_ENTITY Suppresses|nsubj|END_ENTITY	miR340 Suppresses the Stem-like Cell Function of Glioma-Initiating Cells by Targeting Tissue_Plasminogen_Activator .
11246540	0	Tissue_factor_pathway_inhibitor	0,31	TFPI	33,37	Tissue factor pathway inhibitor	TFPI	7035	7035	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- levels in the plasma and urine of children with meningococcal_disease .
11278667	0	Tissue_factor_pathway_inhibitor	0,31	very_low_density_lipoprotein_receptor	97,134	Tissue factor pathway inhibitor	very low density lipoprotein receptor	7035	7436	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Tissue_factor_pathway_inhibitor inhibits endothelial cell proliferation via association with the very_low_density_lipoprotein_receptor .
10984610	0	Tissue_factor_pathway_inhibitor-2	0,33	matrix_metalloproteinase-2	70,96	Tissue factor pathway inhibitor-2	matrix metalloproteinase-2	7980	4313	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|nmod|END_ENTITY	Tissue_factor_pathway_inhibitor-2 suppresses the production of active matrix_metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes .
17023682	0	Tissue_factor_pathway_inhibitor-2	0,33	vascular_endothelial_growth_factor	52,86	Tissue factor pathway inhibitor-2	vascular endothelial growth factor	7980	7422	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Tissue_factor_pathway_inhibitor-2 is upregulated by vascular_endothelial_growth_factor and suppresses growth factor-induced proliferation of endothelial cells .
21515313	0	Tissue_factor_pathway_inhibitor_2	0,33	thrombin	48,56	Tissue factor pathway inhibitor 2	thrombin	7980	2147	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Tissue_factor_pathway_inhibitor_2 is induced by thrombin in human macrophages .
10430177	0	Tissue_inhibitor_of_metalloproteinase-2	0,39	TIMP-2	41,47	Tissue inhibitor of metalloproteinase-2	TIMP-2	282093(Tax:9913)	282093(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- expression is strongly induced by ACTH in adrenocortical cells .
16805810	0	Tissue_inhibitor_of_metalloproteinase-2	0,39	TIMP-2	41,47	Tissue inhibitor of metalloproteinase-2	TIMP-2	7077	7077	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- expression is regulated by multiple neural differentiation signals .
8655631	0	Tissue_inhibitor_of_metalloproteinase-2	0,39	TIMP-2	41,47	Tissue inhibitor of metalloproteinase-2	TIMP-2	282093(Tax:9913)	282093(Tax:9913)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- mRNA is constitutively expressed in bovine , human normal , and osteoarthritic articular chondrocytes .
9422789	0	Tissue_inhibitor_of_metalloproteinase-2	0,39	membrane_type_1-matrix_metalloproteinase_1	109,151	Tissue inhibitor of metalloproteinase-2	membrane type 1-matrix metalloproteinase 1	7077	4323	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- binds to the catalytic domain of the cell surface receptor , membrane_type_1-matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- .
23555662	0	Tissue_inhibitor_of_metalloproteinase_1	0,39	Th1	71,74	Tissue inhibitor of metalloproteinase 1	Th1	7076	51497	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Tissue_inhibitor_of_metalloproteinase_1 is preferentially expressed in Th1 and Th17 T-helper cell subsets and is a direct STAT target gene .
10098765	0	Tissue_inhibitor_of_metalloproteinases-1	0,40	TIMP-1	42,48	Tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- mRNA is elevated in advanced stages of thyroid_carcinoma .
2380196	0	Tissue_inhibitor_of_metalloproteinases-2	0,40	TIMP-2	42,48	Tissue inhibitor of metalloproteinases-2	TIMP-2	7077	7077	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- mRNA expression in tumor cell lines and human tumor tissues .
11948685	0	Tissue_inhibitor_of_metalloproteinases-4	0,40	TIMP-4	42,48	Tissue inhibitor of metalloproteinases-4	TIMP-4	7079	7079	Gene	Gene	increased|nsubjpass|START_ENTITY increased|dep|END_ENTITY	Tissue_inhibitor_of_metalloproteinases-4 -LRB- TIMP-4 -RRB- gene expression is increased in human osteoarthritic femoral head cartilage .
11978811	0	Tissue_plasminogen_activator	0,28	annexin_II	90,100	Tissue plasminogen activator	annexin II	100128998	302	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Tissue_plasminogen_activator mediates microglial activation via its finger domain through annexin_II .
9545344	0	Tissue_plasminogen_activator	0,28	annexin_II	44,54	Tissue plasminogen activator	annexin II	100128998	302	Gene	Gene	START_ENTITY|xcomp|binding binding|nmod|domain domain|amod|END_ENTITY	Tissue_plasminogen_activator binding to the annexin_II tail domain .
10625711	0	Tissue_plasminogen_activator	0,28	plasminogen_activator_inhibitor-1	98,131	Tissue plasminogen activator	plasminogen activator inhibitor-1	100128998	5054	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	Tissue_plasminogen_activator , plasminogen_activator_inhibitor-1 , and tissue_plasminogen_activator / plasminogen_activator_inhibitor-1 complex as risk factors for the development of a first stroke .
9461198	0	Tissue_plasminogen_activator	0,28	tPA	30,33	Tissue plasminogen activator	tPA	18791(Tax:10090)	18791(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Tissue_plasminogen_activator -LRB- tPA -RRB- increases neuronal_damage after focal cerebral_ischemia in wild-type and tPA-deficient mice .
8880017	0	Tissue_plasminogen_activator	0,28	tissue_plasminogen_activator	30,58	Tissue plasminogen activator	tissue plasminogen activator	100128998	100128998	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Tissue_plasminogen_activator , tissue_plasminogen_activator inhibitor and lipoprotein -LRB- a -RRB- in patients with coronary , epiaortic and peripheral_occlusive_artery_disease .
23185316	0	Tissue_transglutaminase	0,23	HIF-1a	49,55	Tissue transglutaminase	HIF-1a	7052	3091	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Tissue_transglutaminase constitutively activates HIF-1a promoter and nuclear factor-kB via a non-canonical pathway .
23185316	0	Tissue_transglutaminase	0,23	HIF-1a	49,55	Tissue transglutaminase	HIF-1a	7052	3091	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Tissue_transglutaminase constitutively activates HIF-1a promoter and nuclear factor-kB via a non-canonical pathway .
23640056	0	Tissue_transglutaminase	0,23	b-catenin	34,43	Tissue transglutaminase	b-catenin	7052	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tissue_transglutaminase regulates b-catenin signaling through a c-Src-dependent mechanism .
23640056	0	Tissue_transglutaminase	0,23	b-catenin	34,43	Tissue transglutaminase	b-catenin	7052	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tissue_transglutaminase regulates b-catenin signaling through a c-Src-dependent mechanism .
23380076	0	Tissue_transglutaminase	0,23	beclin_1	36,44	Tissue transglutaminase	beclin 1	7052	8678	Gene	Gene	cross-links|amod|START_ENTITY END_ENTITY|nsubj|cross-links	Tissue_transglutaminase cross-links beclin_1 and regulates autophagy in MPP ___ - treated human SH-SY5Y cells .
19324884	0	Tissue_transglutaminase	0,23	matrix_metalloproteinase-2	34,60	Tissue transglutaminase	matrix metalloproteinase-2	7052	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Tissue_transglutaminase regulates matrix_metalloproteinase-2 in ovarian_cancer by modulating cAMP-response element-binding protein activity .
19324884	0	Tissue_transglutaminase	0,23	matrix_metalloproteinase-2	34,60	Tissue transglutaminase	matrix metalloproteinase-2	7052	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Tissue_transglutaminase regulates matrix_metalloproteinase-2 in ovarian_cancer by modulating cAMP-response element-binding protein activity .
12209887	0	Titin-cap	0,9	Myostatin	55,64	Titin-cap	Myostatin	8557	2660	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Titin-cap associates with , and regulates secretion of , Myostatin .
19540230	0	Tks5	0,4	AFAP-110	14,22	Tks5	AFAP-110	9644	60312	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Tks5 recruits AFAP-110 , p190RhoGAP , and cortactin for podosome formation .
19736326	0	Tle4	45,49	Otx2	65,69	Tle4	Otx2	374080(Tax:9031)	395191(Tax:9031)	Gene	Gene	START_ENTITY|nmod|binding binding|nmod|END_ENTITY	Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer .
12377769	0	Tlg1p	42,47	Vps51p	0,6	Tlg1p	Vps51p	852079(Tax:4932)	853890(Tax:4932)	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	Vps51p links the VFT complex to the SNARE Tlg1p .
11432826	0	Tlg2p	41,46	Vps45p	0,6	Tlg2p	Vps45p	854142(Tax:4932)	852785(Tax:4932)	Gene	Gene	homologue|dobj|START_ENTITY syntaxin|acl|homologue stabilizes|dobj|syntaxin stabilizes|nsubj|END_ENTITY	Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation .
17904527	0	Tlg2p	32,37	Vps45p	83,89	Tlg2p	Vps45p	854142(Tax:4932)	852785(Tax:4932)	Gene	Gene	levels|nmod|START_ENTITY regulated|nsubjpass|levels regulated|nmod|mode mode|nmod|binding binding|nmod|END_ENTITY	Cellular levels of the syntaxin Tlg2p are regulated by a single mode of binding to Vps45p .
19667197	0	Tlg2p	39,44	Vps45p	93,99	Tlg2p	Vps45p	854142(Tax:4932)	852785(Tax:4932)	Gene	Gene	peptide|nmod|START_ENTITY modulates|nsubj|peptide modulates|dobj|binding binding|nmod|conformation conformation|nmod|END_ENTITY	The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p .
9930650	0	Tlg2p	49,54	Vps45p	20,26	Tlg2p	Vps45p	854142(Tax:4932)	852785(Tax:4932)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The Sec1p homologue Vps45p binds to the syntaxin Tlg2p .
11432826	0	Tlg2p	41,46	syntaxin	22,30	Tlg2p	syntaxin	854142(Tax:4932)	851219(Tax:4932)	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation .
20442858	0	Tlr2	115,119	Tlr4	108,112	Tlr2	Tlr4	24088(Tax:10090)	21898(Tax:10090)	Gene	Gene	responses|appos|START_ENTITY responses|nmod|Trypanosoma_cruzi Trypanosoma_cruzi|nmod|END_ENTITY	Impaired innate immunity in Tlr4 -LRB- - / - -RRB- mice but preserved CD8 + T cell responses against Trypanosoma_cruzi in Tlr4 - , Tlr2 - , Tlr9 - or Myd88-deficient mice .
20442858	0	Tlr2	115,119	Tlr9	122,126	Tlr2	Tlr9	24088(Tax:10090)	81897(Tax:10090)	Gene	Gene	responses|appos|START_ENTITY responses|appos|mice mice|amod|END_ENTITY	Impaired innate immunity in Tlr4 -LRB- - / - -RRB- mice but preserved CD8 + T cell responses against Trypanosoma_cruzi in Tlr4 - , Tlr2 - , Tlr9 - or Myd88-deficient mice .
20442858	0	Tlr4	108,112	Tlr2	115,119	Tlr4	Tlr2	21898(Tax:10090)	24088(Tax:10090)	Gene	Gene	Trypanosoma_cruzi|nmod|START_ENTITY responses|nmod|Trypanosoma_cruzi responses|appos|END_ENTITY	Impaired innate immunity in Tlr4 -LRB- - / - -RRB- mice but preserved CD8 + T cell responses against Trypanosoma_cruzi in Tlr4 - , Tlr2 - , Tlr9 - or Myd88-deficient mice .
20442858	0	Tlr4	108,112	Tlr9	122,126	Tlr4	Tlr9	21898(Tax:10090)	81897(Tax:10090)	Gene	Gene	Trypanosoma_cruzi|nmod|START_ENTITY responses|nmod|Trypanosoma_cruzi responses|appos|mice mice|amod|END_ENTITY	Impaired innate immunity in Tlr4 -LRB- - / - -RRB- mice but preserved CD8 + T cell responses against Trypanosoma_cruzi in Tlr4 - , Tlr2 - , Tlr9 - or Myd88-deficient mice .
10756091	0	Tlr5	65,69	toll-like_receptor_5	43,63	Tlr5	toll-like receptor 5	53791(Tax:10090)	53791(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of the murine toll-like_receptor_5 -LRB- Tlr5 -RRB- gene : sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice .
20442858	0	Tlr9	122,126	Tlr2	115,119	Tlr9	Tlr2	81897(Tax:10090)	24088(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY responses|appos|mice responses|appos|END_ENTITY	Impaired innate immunity in Tlr4 -LRB- - / - -RRB- mice but preserved CD8 + T cell responses against Trypanosoma_cruzi in Tlr4 - , Tlr2 - , Tlr9 - or Myd88-deficient mice .
20442858	0	Tlr9	122,126	Tlr4	108,112	Tlr9	Tlr4	81897(Tax:10090)	21898(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY responses|appos|mice responses|nmod|Trypanosoma_cruzi Trypanosoma_cruzi|nmod|END_ENTITY	Impaired innate immunity in Tlr4 -LRB- - / - -RRB- mice but preserved CD8 + T cell responses against Trypanosoma_cruzi in Tlr4 - , Tlr2 - , Tlr9 - or Myd88-deficient mice .
22194602	0	Tlx	67,70	SRY-box-containing_gene_2	0,25	Tlx	SRY-box-containing gene 2	4179	6657	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	SRY-box-containing_gene_2 regulation of nuclear receptor tailless -LRB- Tlx -RRB- transcription in adult neural stem cells .
7908826	0	Tlx-1	49,54	HOX11	78,83	Tlx-1	HOX11	21908(Tax:10090)	21908(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Characterization and developmental expression of Tlx-1 , the murine homolog of HOX11 .
21744064	0	Tlx3	80,84	HOX11L2	86,93	Tlx3	HOX11L2	30012	30012	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Hes-1 regulates the excitatory fate of neural progenitors through modulation of Tlx3 -LRB- HOX11L2 -RRB- expression .
11863852	0	Tm3	141,144	CaF2	149,153	Tm3	CaF2	7170	9337	Gene	Gene	+|compound|START_ENTITY +|nmod|END_ENTITY	Reappearance of fine structure as a probe of lifetime broadening mechanisms in the 4f -LRB- N -RRB- _ -- > _ 4f -LRB- N-1 -RRB- 5d excitation spectra of Tb3 + , Er3 + , and Tm3 + in CaF2 and LiYF4 .
15682397	0	Tm4sf9	15,21	Tetraspanin-5	0,13	Tm4sf9	Tetraspanin-5	56224(Tax:10090)	56224(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tetraspanin-5 -LRB- Tm4sf9 -RRB- mRNA expression parallels neuronal maturation in the cerebellum of normal and L7En-2 transgenic_mice .
22851706	0	Tmevpg1	27,34	Ifng	90,94	Tmevpg1	Ifng	103214(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|acl|END_ENTITY	Cutting edge : influence of Tmevpg1 , a long intergenic noncoding RNA , on the expression of Ifng by Th1 cells .
10376215	0	Tmp21	37,42	p23	44,47	Tmp21	p23	10972	10972	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A comparative study of rat and human Tmp21 -LRB- p23 -RRB- reveals the pseudogene-like features of human Tmp21-II .
21597760	0	Tnf-alpha	0,9	gm-csf	18,24	Tnf-alpha	gm-csf	7124	1437	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|amod|END_ENTITY	Tnf-alpha induces gm-csf secretion in leukemic-cell lines u-937 and kg-1a .
24802997	0	Tnfa	0,4	tnfr2	23,28	Tnfa	tnfr2	7124	7133	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation .
22808010	0	Tnfr-sf13c	77,87	EPO	111,114	Tnfr-sf13c	EPO	115650	2056	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	Defining an EPOR - regulated transcriptome for primary progenitors , including Tnfr-sf13c as a novel mediator of EPO - dependent erythroblast formation .
16093357	0	Tnfrsf1a	117,125	TNFRSF1B	86,94	Tnfrsf1a	TNFRSF1B	25625(Tax:10116)	156767(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Experimental intestinal endometriosis is characterized by increased levels of soluble TNFRSF1B and downregulation of Tnfrsf1a and Tnfrsf1b gene expression .
23178487	0	Tob	26,29	CPEB	141,145	Tob	CPEB	10140	64506	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic_polyadenylation_element-binding_protein CPEB .
23178487	0	Tob	26,29	c-myc	49,54	Tob	c-myc	10140	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic_polyadenylation_element-binding_protein CPEB .
11260258	0	Tob	80,83	p90rsk1	26,33	Tob	p90rsk1	22057(Tax:10090)	20111(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob .
21087929	0	Tof1	37,41	Rrm3	73,77	Tof1	Rrm3	855448(Tax:4932)	856426(Tax:4932)	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces_cerevisiae .
11731453	0	Toll	72,76	Pelle	19,24	Toll	Pelle	43222(Tax:7227)	43283(Tax:7227)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway .
11934858	0	Toll	56,60	Pelle	0,5	Toll	Pelle	43222(Tax:7227)	43283(Tax:7227)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|kinase kinase|amod|END_ENTITY	Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila .
21576362	0	Toll	35,39	Spn1	0,4	Toll	Spn1	43222(Tax:7227)	49808(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Spn1 regulates the GNBP3-dependent Toll signaling pathway in Drosophila_melanogaster .
26405273	0	Toll	11,15	TLR3	59,63	Toll	TLR3	7099	7098	Gene	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Paying the Toll for Glucose Regulation : A Central Role for TLR3 .
11742401	0	Toll	11,15	peptidoglycan_recognition_protein	77,110	Toll	peptidoglycan recognition protein	43222(Tax:7227)	32534(Tax:7227)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan_recognition_protein .
12098703	0	Toll	25,29	serine_protease	65,80	Toll	serine protease	43222(Tax:7227)	43545(Tax:7227)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Drosophila Toll during fungal_infection by a blood serine_protease .
22022271	0	Toll-8	0,6	Tollo	7,12	Toll-8	Tollo	44497(Tax:7227)	44497(Tax:7227)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	Toll-8 / Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium .
25759837	0	Toll-Like_Receptor-4	20,40	TLR-4	42,47	Toll-Like Receptor-4	TLR-4	21898(Tax:10090)	21898(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of Toll-Like_Receptor-4 -LRB- TLR-4 -RRB- in the Spleen and Thymus of Swiss Albino Mice and Its Modulation in Experimental Endotoxemia .
23926349	0	Toll-Like_Receptor_2	84,104	NSP4	10,14	Toll-Like Receptor 2	NSP4	7097	400668	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|compound|END_ENTITY	Rotavirus NSP4 Triggers Secretion of Proinflammatory Cytokines from Macrophages via Toll-Like_Receptor_2 .
26668319	0	Toll-Like_Receptor_2	36,56	Nerve_Growth_Factor	0,19	Toll-Like Receptor 2	Nerve Growth Factor	7097	4803	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|END_ENTITY	Nerve_Growth_Factor is Regulated by Toll-Like_Receptor_2 in Human Intervertebral Discs .
25264029	0	Toll-Like_Receptor_3	48,68	Stat3	94,99	Toll-Like Receptor 3	Stat3	142980(Tax:10090)	20848(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|retina retina|nmod|END_ENTITY	A novel protective role for the innate immunity Toll-Like_Receptor_3 -LRB- TLR3 -RRB- in the retina via Stat3 .
25264029	0	Toll-Like_Receptor_3	48,68	TLR3	70,74	Toll-Like Receptor 3	TLR3	142980(Tax:10090)	142980(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel protective role for the innate immunity Toll-Like_Receptor_3 -LRB- TLR3 -RRB- in the retina via Stat3 .
24902807	0	Toll-Like_Receptor_4	38,58	Lectin-Like_ox-LDL_Receptor-1	0,29	Toll-Like Receptor 4	Lectin-Like ox-LDL Receptor-1	21898(Tax:10090)	108078(Tax:10090)	Gene	Gene	Interaction|compound|START_ENTITY END_ENTITY|dep|Interaction	Lectin-Like_ox-LDL_Receptor-1 -LRB- LOX-1 -RRB- - Toll-Like_Receptor_4 -LRB- TLR4 -RRB- Interaction and Autophagy in CATH.a Differentiated Cells Exposed to Angiotensin_II .
25171655	0	Toll-Like_Receptor_4	54,74	Nuclear_Factor_Erythroid_2-Related_Factor_2	0,43	Toll-Like Receptor 4	Nuclear Factor Erythroid 2-Related Factor 2	21898(Tax:10090)	18024(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	Nuclear_Factor_Erythroid_2-Related_Factor_2 Regulates Toll-Like_Receptor_4 Innate Responses in Mouse Liver_Ischemia-Reperfusion Injury Through Akt-Forkhead box Protein O1 Signaling Network .
25984739	0	Toll-Like_Receptor_4	42,62	THP-1	89,94	Toll-Like Receptor 4	THP-1	7099	2736	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	MiRNA-194 Regulates Palmitic_Acid-Induced Toll-Like_Receptor_4 Inflammatory Responses in THP-1 Cells .
25732404	0	Toll-like_Receptor_4	70,90	67_kDa_Laminin_Receptor	111,134	Toll-like Receptor 4	67 kDa Laminin Receptor	7099	3921	Gene	Gene	Activity|compound|START_ENTITY Activity|nmod|END_ENTITY	Epigallocatechin_Gallate -LRB- EGCG -RRB- Suppresses Lipopolysaccharide-Induced Toll-like_Receptor_4 -LRB- TLR4 -RRB- Activity via 67_kDa_Laminin_Receptor -LRB- 67LR -RRB- in 3T3-L1 Adipocytes .
26603204	0	Toll-like_Receptor_4	0,20	Interleukin_10	126,140	Toll-like Receptor 4	Interleukin 10	21898(Tax:10090)	16153(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Suppresses|nsubj|Signaling Suppresses|xcomp|Expression Expression|dep|END_ENTITY	Toll-like_Receptor_4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin_10 During Intra-abdominal_Sepsis .
25732404	0	Toll-like_Receptor_4	70,90	TLR4	92,96	Toll-like Receptor 4	TLR4	7099	7099	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Epigallocatechin_Gallate -LRB- EGCG -RRB- Suppresses Lipopolysaccharide-Induced Toll-like_Receptor_4 -LRB- TLR4 -RRB- Activity via 67_kDa_Laminin_Receptor -LRB- 67LR -RRB- in 3T3-L1 Adipocytes .
22982459	0	Toll-like_receptor-2	99,119	Biglycan	0,8	Toll-like receptor-2	Biglycan	7097	633	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Biglycan induces the expression of osteogenic factors in human aortic valve interstitial cells via Toll-like_receptor-2 .
21791592	0	Toll-like_receptor-2	10,30	CD16	56,60	Toll-like receptor-2	CD16	7097	2214	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Increased Toll-like_receptor-2 expression on nonclassic CD16 + monocytes from patients with inflammatory stage of Eales ' _ disease .
24371584	0	Toll-like_receptor-2	33,53	Estrogen_receptor-alpha	0,23	Toll-like receptor-2	Estrogen receptor-alpha	7097	2099	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Estrogen_receptor-alpha mediates Toll-like_receptor-2 agonist-induced monocyte_chemoattractant_protein-1 production in mesangial cells .
24371584	0	Toll-like_receptor-2	33,53	monocyte_chemoattractant_protein-1	70,104	Toll-like receptor-2	monocyte chemoattractant protein-1	7097	6347	Gene	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	Estrogen_receptor-alpha mediates Toll-like_receptor-2 agonist-induced monocyte_chemoattractant_protein-1 production in mesangial cells .
19378032	0	Toll-like_receptor-4	53,73	A20	23,26	Toll-like receptor-4	A20	7099	7128	Gene	Gene	stimulation|compound|START_ENTITY expression|nmod|stimulation expression|nmod|END_ENTITY	Cellular expression of A20 and ABIN-3 in response to Toll-like_receptor-4 stimulation .
12865424	0	Toll-like_receptor-4	25,45	AKT	115,118	Toll-like receptor-4	AKT	7099	207	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nsubj|modulation	Reciprocal modulation of Toll-like_receptor-4 signaling pathways involving MyD88 and phosphatidylinositol_3-kinase / AKT by saturated and polyunsaturated_fatty_acids .
25059667	0	Toll-like_receptor-4	23,43	CD33	172,176	Toll-like receptor-4	CD33	7099	945	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Negative regulation of Toll-like_receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein , CD14 , with the sialic_acid-binding lectin , CD33 .
16952555	0	Toll-like_receptor-4	22,42	Cox-2	0,5	Toll-like receptor-4	Cox-2	21898(Tax:10090)	19225(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cox-2 is regulated by Toll-like_receptor-4 -LRB- TLR4 -RRB- signaling : Role in proliferation and apoptosis in the intestine .
15878984	0	Toll-like_receptor-4	0,20	Cyp3a11	43,50	Toll-like receptor-4	Cyp3a11	21898(Tax:10090)	13112(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Toll-like_receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation .
22699754	0	Toll-like_receptor-4	97,117	Tenascin-C	0,10	Toll-like receptor-4	Tenascin-C	7099	3371	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Tenascin-C produced by oxidized LDL-stimulated macrophages increases foam cell formation through Toll-like_receptor-4 .
19735472	0	Toll-like_receptor-4	0,20	beta-defensin-2	43,58	Toll-like receptor-4	beta-defensin-2	7099	1673	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Toll-like_receptor-4 -LRB- TLR4 -RRB- mediates human beta-defensin-2 -LRB- HBD-2 -RRB- induction in response to Chlamydia_pneumoniae in mononuclear cells .
24622882	0	Toll-like_receptor-9	8,28	CD14	54,58	Toll-like receptor-9	CD14	54106	929	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduced Toll-like_receptor-9 expression on peripheral CD14 + monocytes of chronic hepatitis_B patients and its restoration by effective therapy .
25544311	0	Toll-like_receptor_1	0,20	TLR1	21,25	Toll-like receptor 1	TLR1	7096	7096	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Toll-like_receptor_1 -LRB- TLR1 -RRB- Gene SNP rs5743618 is associated with increased risk for tuberculosis in Han Chinese children .
11932926	0	Toll-like_receptor_1	0,20	Toll-like_receptor_4	30,50	Toll-like receptor 1	Toll-like receptor 4	7096	7099	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Toll-like_receptor_1 inhibits Toll-like_receptor_4 signaling in endothelial cells .
21716313	0	Toll-like_receptor_10	15,36	NOD2	90,94	Toll-like receptor 10	NOD2	81793	64127	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Toll-like_receptor_10 and susceptibility to Crohn 's _ disease independent of NOD2 .
18241264	0	Toll-like_receptor_2	0,20	C-type_lectin_receptor	89,111	Toll-like receptor 2	C-type lectin receptor	7097	338339	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Toll-like_receptor_2 is highly expressed in lesions of acne inversa and colocalizes with C-type_lectin_receptor .
16632602	0	Toll-like_receptor_2	0,20	CD25	63,67	Toll-like receptor 2	CD25	24088(Tax:10090)	16184(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY modulates|nsubj|signaling modulates|dobj|functions functions|nmod|cells cells|compound|END_ENTITY	Toll-like_receptor_2 signaling modulates the functions of CD4 + CD25 + regulatory T cells .
12816980	0	Toll-like_receptor_2	57,77	CD4	119,122	Toll-like receptor 2	CD4	7097	920	Gene	Gene	Cutting|xcomp|START_ENTITY internalizes|csubj|Cutting internalizes|nmod|cells cells|compound|END_ENTITY	Cutting edge : link between innate and adaptive immunity : Toll-like_receptor_2 internalizes antigen for presentation to CD4 + T cells and could be an efficient vaccine target .
16632602	0	Toll-like_receptor_2	0,20	CD4	58,61	Toll-like receptor 2	CD4	24088(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY modulates|nsubj|signaling modulates|dobj|functions functions|nmod|cells cells|compound|END_ENTITY	Toll-like_receptor_2 signaling modulates the functions of CD4 + CD25 + regulatory T cells .
19552525	0	Toll-like_receptor_2	14,34	CD4	38,41	Toll-like receptor 2	CD4	7097	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Engagement of Toll-like_receptor_2 on CD4 -LRB- + -RRB- T cells facilitates local immune responses in patients with tuberculous_pleurisy .
20434372	0	Toll-like_receptor_2	0,20	CD4	34,37	Toll-like receptor 2	CD4	7097	920	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|T T|compound|END_ENTITY	Toll-like_receptor_2 signaling in CD4 -LRB- + -RRB- T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune_disease .
26714796	0	Toll-like_receptor_2	86,106	CD4	147,150	Toll-like receptor 2	CD4	24088(Tax:10090)	12504(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY influences|nsubj|signalling influences|dobj|END_ENTITY	Patency of Litomosoides_sigmodontis_infection depends on Toll-like_receptor_4 whereas Toll-like_receptor_2 signalling influences filarial-specific CD4 -LRB- + -RRB- T-cell responses .
18952897	0	Toll-like_receptor_2	62,82	G-CSF	24,29	Toll-like receptor 2	G-CSF	24088(Tax:10090)	12985(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Serum_amyloid_A induces G-CSF expression and neutrophilia via Toll-like_receptor_2 .
18195725	0	Toll-like_receptor_2	0,20	IL-10	47,52	Toll-like receptor 2	IL-10	7097	3586	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Toll-like_receptor_2 mediates the induction of IL-10 in corneal fibroblasts in response to Fusarium solu .
24717875	0	Toll-like_receptor_2	58,78	MUC5B	37,42	Toll-like receptor 2	MUC5B	7097	727897	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Staphylococcus enterotoxin A induces MUC5B expression via Toll-like_receptor_2 , extracellular_signal-regulated_kinase_1 / 2 , and p38_mitogen-activated_protein_kinase in human airway epithelial cells .
19602669	0	Toll-like_receptor_2	72,92	MyD88	121,126	Toll-like receptor 2	MyD88	24088(Tax:10090)	17874(Tax:10090)	Gene	Gene	START_ENTITY|nmod|involvement involvement|nmod|END_ENTITY	Impaired osteoclastogenesis by staphylococcal lipoteichoic acid through Toll-like_receptor_2 with partial involvement of MyD88 .
22051147	0	Toll-like_receptor_2	0,20	MyD88	21,26	Toll-like receptor 2	MyD88	24088(Tax:10090)	17874(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Toll-like_receptor_2 / MyD88 signaling mediates zymosan-induced joint hypernociception in mice : participation of TNF-a , IL-1b and CXCL1/KC .
23826757	0	Toll-like_receptor_2	2,22	MyD88	130,135	Toll-like receptor 2	MyD88	24088(Tax:10090)	17874(Tax:10090)	Gene	Gene	ligand|compound|START_ENTITY augments|nsubj|ligand augments|dobj|production production|nmod|association association|nmod|END_ENTITY	A Toll-like_receptor_2 ligand , Pam3CSK4 , augments interferon-y-induced nitric_oxide production via a physical association between MyD88 and interferon-y receptor in vascular endothelial cells .
23386616	0	Toll-like_receptor_2	0,20	NADPH_oxidase_2	62,77	Toll-like receptor 2	NADPH oxidase 2	24088(Tax:10090)	13058(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Toll-like_receptor_2 mediates peripheral nerve_injury-induced NADPH_oxidase_2 expression in spinal cord microglia .
21709223	0	Toll-like_receptor_2	121,141	SHANK-associated_RH_domain-interacting_protein	50,96	Toll-like receptor 2	SHANK-associated RH domain-interacting protein	24088(Tax:10090)	106025(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY END_ENTITY|nmod|responses	Systems analysis identifies an essential role for SHANK-associated_RH_domain-interacting_protein -LRB- SHARPIN -RRB- in macrophage Toll-like_receptor_2 -LRB- TLR2 -RRB- responses .
18952897	0	Toll-like_receptor_2	62,82	Serum_amyloid_A	0,15	Toll-like receptor 2	Serum amyloid A	24088(Tax:10090)	111345(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Serum_amyloid_A induces G-CSF expression and neutrophilia via Toll-like_receptor_2 .
24476318	0	Toll-like_receptor_2	64,84	Serum_amyloid_A	0,15	Toll-like receptor 2	Serum amyloid A	7097	6287	Gene	Gene	fibroblasts|nmod|START_ENTITY induces|nmod|fibroblasts induces|nsubj|END_ENTITY	Serum_amyloid_A induces interleukin-6 in dermal fibroblasts via Toll-like_receptor_2 , interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB .
16283346	0	Toll-like_receptor_2	0,20	TLR2	22,26	Toll-like receptor 2	TLR2	7097	7097	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Toll-like_receptor_2 -LRB- TLR2 -RRB- mediates intracellular signalling in human keratinocytes in response to Malassezia furfur .
23279536	0	Toll-like_receptor_2	20,40	TLR2	42,46	Toll-like receptor 2	TLR2	448807(Tax:9615)	448807(Tax:9615)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	The localization of Toll-like_receptor_2 -LRB- TLR2 -RRB- in the endometrium and the cervix of dogs at different stages of the oestrous cycle and with pyometra .
18606009	0	Toll-like_receptor_2	66,86	Yps3p	52,57	Toll-like receptor 2	Yps3p	24088(Tax:10090)	850812(Tax:4932)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Histoplasma_capsulatum yeast phase-specific protein Yps3p induces Toll-like_receptor_2 signaling .
11745329	0	Toll-like_receptor_2	6,26	beta-defensin_2	81,96	Toll-like receptor 2	beta-defensin 2	7097	100289462	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Human Toll-like_receptor_2 mediates induction of the antimicrobial peptide human beta-defensin_2 in response to bacterial lipoprotein .
12958190	0	Toll-like_receptor_2	70,90	beta-defensin_2	46,61	Toll-like receptor 2	beta-defensin 2	7097	1673	Gene	Gene	regulate|nmod|START_ENTITY regulate|dobj|expression expression|nmod|END_ENTITY	Airway epithelia regulate expression of human beta-defensin_2 through Toll-like_receptor_2 .
15270740	0	Toll-like_receptor_2	111,131	interleukin-10	27,41	Toll-like receptor 2	interleukin-10	7097	3586	Gene	Gene	mutation|compound|START_ENTITY production|nmod|mutation production|nmod|patients patients|amod|END_ENTITY	Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like_receptor_2 mutation .
17420232	0	Toll-like_receptor_2	70,90	interleukin-10	119,133	Toll-like receptor 2	interleukin-10	24088(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Growth of Yersinia_pseudotuberculosis in mice occurs independently of Toll-like_receptor_2 expression and induction of interleukin-10 .
21190299	0	Toll-like_receptor_2	0,20	myeloperoxidase	34,49	Toll-like receptor 2	myeloperoxidase	24088(Tax:10090)	17523(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Toll-like_receptor_2 induces Th17 myeloperoxidase autoimmunity while Toll-like_receptor_9 drives Th1 autoimmunity in murine vasculitis .
11867688	0	Toll-like_receptor_2	0,20	p38	79,82	Toll-like receptor 2	p38	7097	1432	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Toll-like_receptor_2 -LRB- TLR2 -RRB- mediates activation of stress-activated MAP kinase p38 .
22768778	0	Toll-like_receptor_2	11,31	receptor_activator_of_nuclear_factor-kappaB_ligand	74,124	Toll-like receptor 2	receptor activator of nuclear factor-kappaB ligand	7097	8600	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Toll-like_receptor_2 and Toll-like_receptor_4 on expression of receptor_activator_of_nuclear_factor-kappaB_ligand in human periodontal ligament fibroblasts induced by lipopolysaccharide -RSB- .
23804239	0	Toll-like_receptor_3	50,70	HSP27	14,19	Toll-like receptor 3	HSP27	7098	3315	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Extracellular HSP27 mediates angiogenesis through Toll-like_receptor_3 .
24708416	0	Toll-like_receptor_3	43,63	Interleukin-17	0,14	Toll-like receptor 3	Interleukin-17	7098	3605	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-17 increases the expression of Toll-like_receptor_3 via the STAT3 pathway in rheumatoid_arthritis fibroblast-like synoviocytes .
24708416	0	Toll-like_receptor_3	43,63	STAT3	72,77	Toll-like receptor 3	STAT3	7098	6774	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Interleukin-17 increases the expression of Toll-like_receptor_3 via the STAT3 pathway in rheumatoid_arthritis fibroblast-like synoviocytes .
21216866	0	Toll-like_receptor_3	13,33	TLR3	40,44	Toll-like receptor 3	TLR3	7098	7098	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A functional Toll-like_receptor_3 gene -LRB- TLR3 -RRB- may be a risk factor for tick-borne_encephalitis_virus _ -LRB- TBEV -RRB- _ infection .
21911501	0	Toll-like_receptor_3	0,20	TLR3	22,26	Toll-like receptor 3	TLR3	7098	7098	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Toll-like_receptor_3 -LRB- TLR3 -RRB- signaling requires TLR4_Interactor_with_leucine-rich_REPeats -LRB- TRIL -RRB- .
23716670	0	Toll-like_receptor_3	0,20	TLR3	22,26	Toll-like receptor 3	TLR3	7098	7098	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Toll-like_receptor_3 -LRB- TLR3 -RRB- activation induces microRNA-dependent reexpression of functional RARb and tumor regression .
23578838	0	Toll-like_receptor_3	94,114	TNF-alpha	60,69	Toll-like receptor 3	TNF-alpha	142980(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
23947625	0	Toll-like_receptor_3	94,114	TNF-alpha	60,69	Toll-like receptor 3	TNF-alpha	142980(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	HSV-1 activates NF-kappaB in mouse astrocytes and increases TNF-alpha and IL-6 expression via Toll-like_receptor_3 .
19470740	0	Toll-like_receptor_3	28,48	Wnt5a	66,71	Toll-like receptor 3	Wnt5a	7098	7474	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Phenylmethimazole decreases Toll-like_receptor_3 and noncanonical Wnt5a expression in pancreatic_cancer and melanoma together with tumor cell growth and migration .
16858407	0	Toll-like_receptor_3	0,20	c-Src_tyrosine_kinase	37,58	Toll-like receptor 3	c-Src tyrosine kinase	7098	1445	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Toll-like_receptor_3 associates with c-Src_tyrosine_kinase on endosomes to initiate antiviral signaling .
18779317	0	Toll-like_receptor_3	14,34	p53	0,3	Toll-like receptor 3	p53	7098	7157	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p53 regulates Toll-like_receptor_3 expression and function in human epithelial cell lines .
15940673	0	Toll-like_receptor_3_and_4	123,149	NF-kappa_B	64,74	Toll-like receptor 3 and 4	NF-kappa B	7098;7099	4790	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa_B activation and IFN-beta synthesis downstream of Toll-like_receptor_3_and_4 .
25436985	0	Toll-like_receptor_3_and_interleukin_1b	0,39	CD34	54,58	Toll-like receptor 3 and interleukin 1b	CD34	7098;3553	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Toll-like_receptor_3_and_interleukin_1b expression in CD34 + cells from patients with rheumatoid_arthritis : association with inflammation and vascular involvement .
16688168	0	Toll-like_receptor_4	68,88	ATF3	36,40	Toll-like receptor 4	ATF3	21898(Tax:10090)	11910(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Systems biology approaches identify ATF3 as a negative regulator of Toll-like_receptor_4 .
19271152	0	Toll-like_receptor_4	27,47	Angiotensin_II	0,14	Toll-like receptor 4	Angiotensin II	29260(Tax:10116)	24179(Tax:10116)	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Angiotensin_II upregulates Toll-like_receptor_4 and enhances lipopolysaccharide-induced CD40 expression in rat peritoneal mesothelial cells .
23479601	0	Toll-like_receptor_4	82,102	B_and_T_lymphocyte_attenuator	0,29	Toll-like receptor 4	B and T lymphocyte attenuator	21898(Tax:10090)	208154(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	B_and_T_lymphocyte_attenuator inhibits LPS-induced endotoxic_shock by suppressing Toll-like_receptor_4 signaling in innate immune cells .
17045300	0	Toll-like_receptor_4	0,20	C-reactive_protein	130,148	Toll-like receptor 4	C-reactive protein	7099	1401	Gene	Gene	expressions|amod|START_ENTITY enhanced|nsubjpass|expressions enhanced|nmod|patients patients|nmod|END_ENTITY	Toll-like_receptor_4 expressions on peripheral blood monocytes were enhanced in coronary_artery_disease even in patients with low C-reactive_protein .
20332628	0	Toll-like_receptor_4	0,20	C-reactive_protein	75,93	Toll-like receptor 4	C-reactive protein	29260(Tax:10116)	25419(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY mediates|nsubj|signaling mediates|dobj|activation activation|acl|induced induced|nmod|END_ENTITY	Toll-like_receptor_4 signaling mediates inflammatory activation induced by C-reactive_protein in vascular smooth muscle cells .
22088250	0	Toll-like_receptor_4	59,79	C-reactive_protein	32,50	Toll-like receptor 4	C-reactive protein	21898(Tax:10090)	12944(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
15860745	0	Toll-like_receptor_4	17,37	CD14	83,87	Toll-like receptor 4	CD14	7099	929	Gene	Gene	expression|compound|START_ENTITY expression|acl|signaling signaling|nmod|monocytes monocytes|compound|END_ENTITY	Statins decrease Toll-like_receptor_4 expression and downstream signaling in human CD14 + monocytes .
17577821	0	Toll-like_receptor_4	19,39	CD14	43,47	Toll-like receptor 4	CD14	7099	929	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	High expression of Toll-like_receptor_4 on CD14 + monocytes in acute infectious_diseases .
22078883	0	Toll-like_receptor_4	45,65	CD14	0,4	Toll-like receptor 4	CD14	7099	929	Gene	Gene	endocytosis|nmod|START_ENTITY controls|dobj|endocytosis controls|nsubj|END_ENTITY	CD14 controls the LPS-induced endocytosis of Toll-like_receptor_4 .
22088250	0	Toll-like_receptor_4	59,79	CD14	94,98	Toll-like receptor 4	CD14	21898(Tax:10090)	12475(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effects of atorvastatin on C-reactive_protein induced Toll-like_receptor_4 expression on CD14 + monocyte -RSB- .
23595503	0	Toll-like_receptor_4	61,81	CD14	23,27	Toll-like receptor 4	CD14	7099	929	Gene	Gene	expression|compound|START_ENTITY subset|nmod|expression subset|compound|END_ENTITY	Reduced frequency of a CD14 + CD16 + monocyte subset with high Toll-like_receptor_4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns .
24518547	0	Toll-like_receptor_4	23,43	CD14	69,73	Toll-like receptor 4	CD14	7099	929	Gene	Gene	expression|compound|START_ENTITY expression|nmod|monocytes monocytes|compound|END_ENTITY	Hydrocortisone reduces Toll-like_receptor_4 expression on peripheral CD14 + monocytes in patients undergoing percutaneous coronary intervention .
26550333	0	Toll-like_receptor_4	24,44	CD14	65,69	Toll-like receptor 4	CD14	7099	929	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Different regulation of Toll-like_receptor_4 expression on blood CD14 -LRB- + -RRB- monocytes by simvastatin in patients with sepsis and severe_sepsis .
23595503	0	Toll-like_receptor_4	61,81	CD16	29,33	Toll-like receptor 4	CD16	7099	2214	Gene	Gene	expression|compound|START_ENTITY subset|nmod|expression subset|compound|END_ENTITY	Reduced frequency of a CD14 + CD16 + monocyte subset with high Toll-like_receptor_4 expression in cord blood compared to adult blood contributes to lipopolysaccharide hyporesponsiveness in newborns .
17032003	0	Toll-like_receptor_4	120,140	CD19	104,108	Toll-like receptor 4	CD19	21898(Tax:10090)	12478(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Bovine beta-casein -LRB- 1-28 -RRB- , a casein phosphopeptide , enhances proliferation and IL-6 expression of mouse CD19 + cells via Toll-like_receptor_4 .
19349620	0	Toll-like_receptor_4	64,84	CD8	105,108	Toll-like receptor 4	CD8	7099	925	Gene	Gene	T-cell|compound|START_ENTITY T-cell|compound|END_ENTITY	Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like_receptor_4 signaling-dependent CD8 T-cell activation .
20018573	0	Toll-like_receptor_4	0,20	Cox-2	72,77	Toll-like receptor 4	Cox-2	21898(Tax:10090)	19225(Tax:10090)	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	Toll-like_receptor_4 participates in gastric mucosal protection through Cox-2 and PGE2 .
24661950	0	Toll-like_receptor_4	36,56	Fibrinogen	0,10	Toll-like receptor 4	Fibrinogen	7099	2244	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Fibrinogen , an endogenous ligand of Toll-like_receptor_4 , activates monocytes in pre-eclamptic patients .
22576743	0	Toll-like_receptor_4	47,67	Foxp3	0,5	Toll-like receptor 4	Foxp3	7099	50943	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Foxp3 expression in A549 cells is regulated by Toll-like_receptor_4 through nuclear factor-kB .
24244627	0	Toll-like_receptor_4	65,85	High-mobility_group_box_1	0,25	Toll-like receptor 4	High-mobility group box 1	21898(Tax:10090)	15289(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	High-mobility_group_box_1 inhibits gastric ulcer_healing through Toll-like_receptor_4 and receptor_for_advanced_glycation_end_products .
21730052	0	Toll-like_receptor_4	0,20	Hsp70-like_protein_1	45,65	Toll-like receptor 4	Hsp70-like protein 1	7099	51182	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	Toll-like_receptor_4 -LRB- TLR4 -RRB- is essential for Hsp70-like_protein_1 -LRB- HSP70L1 -RRB- to activate dendritic cells and induce Th1 response .
16219795	0	Toll-like_receptor_4	46,66	Interferon_regulatory_factor_3	0,30	Toll-like receptor 4	Interferon regulatory factor 3	7099	3661	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Interferon_regulatory_factor_3 is involved in Toll-like_receptor_4 -LRB- TLR4 -RRB- - and TLR3-induced IL-12p35 gene activation .
23141143	0	Toll-like_receptor_4	25,45	Interleukin-10	0,14	Toll-like receptor 4	Interleukin-10	7099	3586	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-10 activates Toll-like_receptor_4 and requires MyD88 for cardiomyocyte survival .
12803886	0	Toll-like_receptor_4	105,125	Macrophage_migration_inhibitory_factor	0,38	Toll-like receptor 4	Macrophage migration inhibitory factor	7099	4282	Gene	Gene	modulation|nmod|START_ENTITY endotoxin|nmod|modulation regulates|xcomp|endotoxin regulates|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- regulates host responses to endotoxin through modulation of Toll-like_receptor_4 -LRB- TLR4 -RRB- .
23411097	0	Toll-like_receptor_4	115,135	Macrophage_migration_inhibitory_factor	0,38	Toll-like receptor 4	Macrophage migration inhibitory factor	7099	4282	Gene	Gene	modulation|nmod|START_ENTITY necessary|nmod|modulation necessary|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor is necessary for the lipo-oligosaccharide-induced response by modulation of Toll-like_receptor_4 in monocytes from GBS patients .
25545945	0	Toll-like_receptor_4	111,131	MicroRNA-181c	0,13	Toll-like receptor 4	MicroRNA-181c	7099	406957	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-181c negatively regulates the inflammatory response in oxygen-glucose-deprived microglia by targeting Toll-like_receptor_4 .
17767165	0	Toll-like_receptor_4	44,64	Mrp8	0,4	Toll-like receptor 4	Mrp8	7099	6279	Gene	Gene	activators|nmod|START_ENTITY activators|nsubj|END_ENTITY	Mrp8 and Mrp14 are endogenous activators of Toll-like_receptor_4 , promoting lethal , endotoxin-induced shock .
15894821	0	Toll-like_receptor_4	8,28	NF-kappaB	29,38	Toll-like receptor 4	NF-kappaB	7099	4790	Gene	Gene	Role|dep|START_ENTITY pathway|dep|Role pathway|amod|END_ENTITY	Role of Toll-like_receptor_4 / NF-kappaB pathway in monocyte-endothelial adhesion induced by low shear stress and ox-LDL .
17082484	0	Toll-like_receptor_4	12,32	NF-kappaB	33,42	Toll-like receptor 4	NF-kappaB	21898(Tax:10090)	18033(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|pathway pathway|amod|END_ENTITY	Role of the Toll-like_receptor_4 / NF-kappaB pathway in saturated_fatty_acid-induced inflammatory changes in the interaction between adipocytes and macrophages .
20400501	0	Toll-like_receptor_4	35,55	Nucleoredoxin	0,13	Toll-like receptor 4	Nucleoredoxin	21898(Tax:10090)	18230(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Nucleoredoxin negatively regulates Toll-like_receptor_4 signaling via recruitment of flightless-I to myeloid_differentiation_primary_response_gene _ -LRB- 88 -RRB- .
15852007	0	Toll-like_receptor_4	23,43	RP105	88,93	Toll-like receptor 4	RP105	7099	883708(Tax:272947)	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of Toll-like_receptor_4 signaling by the Toll-like receptor homolog RP105 .
26149990	0	Toll-like_receptor_4	93,113	Rg1	34,37	Toll-like receptor 4	Rg1	21898(Tax:10090)	140491(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of ginsenosides Rg1 and Re on LPS-induced sepsis by competitive binding to Toll-like_receptor_4 .
26149990	0	Toll-like_receptor_4	93,113	Rg1	34,37	Toll-like receptor 4	Rg1	21898(Tax:10090)	140491(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Protective effect of ginsenosides Rg1 and Re on LPS-induced sepsis by competitive binding to Toll-like_receptor_4 .
21383675	0	Toll-like_receptor_4	46,66	THP-1	146,151	Toll-like receptor 4	THP-1	7099	2736	Gene	Gene	secretion|amod|START_ENTITY interacts|nmod|secretion interacts|nmod|cells cells|compound|END_ENTITY	Mannan-binding_lectin directly interacts with Toll-like_receptor_4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells .
21978170	0	Toll-like_receptor_4	149,169	THP-1	192,197	Toll-like receptor 4	THP-1	7099	2736	Gene	Gene	mediated|amod|START_ENTITY induction|amod|mediated induction|nmod|differentiation/activation differentiation/activation|compound|END_ENTITY	Branched a - -LRB- 1,4 -RRB- glucans from Lentinula edodes -LRB- L10 -RRB- in combination with radiation enhance cytotoxic effect on human lung_adenocarcinoma through the Toll-like_receptor_4 mediated induction of THP-1 differentiation/activation .
22015781	0	Toll-like_receptor_4	0,20	THP-1	63,68	Toll-like receptor 4	THP-1	7099	2736	Gene	Gene	formation|nsubj|START_ENTITY formation|amod|up-regulated up-regulated|nmod|activation activation|nmod|cells cells|amod|macrophage macrophage|amod|END_ENTITY	Toll-like_receptor_4 is up-regulated by mTOR activation during THP-1 macrophage foam cells formation .
18544275	0	Toll-like_receptor_4	20,40	TLR4	42,46	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The significance of Toll-like_receptor_4 -LRB- TLR4 -RRB- expression in patients with chronic hepatitis_B .
19398177	0	Toll-like_receptor_4	38,58	TLR4	60,64	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Evaluation of the polymorphism in the Toll-like_receptor_4 -LRB- TLR4 -RRB- genes of tympanosclerosis patients .
21356084	0	Toll-like_receptor_4	0,20	TLR4	22,26	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Toll-like_receptor_4 -LRB- TLR4 -RRB- expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis .
21664961	0	Toll-like_receptor_4	46,66	TLR4	68,72	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Therapeutic targeting of innate immunity with Toll-like_receptor_4 -LRB- TLR4 -RRB- antagonists .
21752456	0	Toll-like_receptor_4	27,47	TLR4	49,53	Toll-like receptor 4	TLR4	403417(Tax:9615)	403417(Tax:9615)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of Toll-like_receptor_4 -LRB- TLR4 -RRB- in healthy and infected canine endometrium .
22005564	0	Toll-like_receptor_4	34,54	TLR4	56,60	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Platelet parameters and platelet Toll-like_receptor_4 -LRB- TLR4 -RRB- expression in patients with sepsis , and the effect of a joint treatment-plan integrating traditional Chinese and western medicine : a clinical study -RSB- .
23027874	0	Toll-like_receptor_4	86,106	TLR4	108,112	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Profibrotic effect of interleukin-18 in HK-2 cells is dependent on stimulation of the Toll-like_receptor_4 -LRB- TLR4 -RRB- promoter and increased TLR4 expression .
26830904	0	Toll-like_receptor_4	15,35	TLR4	37,41	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of Toll-like_receptor_4 -LRB- TLR4 -RRB- with chronic plaque_type_psoriasis and psoriatic_arthritis .
26831416	0	Toll-like_receptor_4	133,153	TLR4	155,159	Toll-like receptor 4	TLR4	7099	7099	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
16109884	0	Toll-like_receptor_4	45,65	TNF-alpha	12,21	Toll-like receptor 4	TNF-alpha	7099	7124	Gene	Gene	stimulation|compound|START_ENTITY impairs|nmod|stimulation impairs|dobj|release release|amod|END_ENTITY	HIV impairs TNF-alpha release in response to Toll-like_receptor_4 stimulation in human macrophages in vitro .
20018674	0	Toll-like_receptor_4	19,39	TNF-alpha	59,68	Toll-like receptor 4	TNF-alpha	21898(Tax:10090)	21926(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|antagonists antagonists|amod|END_ENTITY	Involvement of the Toll-like_receptor_4 pathway and use of TNF-alpha antagonists for treatment of the mucopolysaccharidoses .
26497121	0	Toll-like_receptor_4	139,159	TNF-alpha	74,83	Toll-like receptor 4	TNF-alpha	21898(Tax:10090)	21926(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY promote|nmod|cells promote|dobj|secretion secretion|nmod|END_ENTITY	Clonorchis_sinensis excretory/secretory products promote the secretion of TNF-alpha in the mouse intrahepatic biliary epithelial cells via Toll-like_receptor_4 .
11970998	0	Toll-like_receptor_4	0,20	Th2	60,63	Toll-like receptor 4	Th2	21898(Tax:10090)	15111(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|responses responses|amod|END_ENTITY	Toll-like_receptor_4 is required for optimal development of Th2 immune responses : role of dendritic cells .
23954950	0	Toll-like_receptor_4	42,62	Thrombospondin_1	0,16	Toll-like receptor 4	Thrombospondin 1	7099	7057	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Thrombospondin_1 activates the macrophage Toll-like_receptor_4 pathway .
11932926	0	Toll-like_receptor_4	30,50	Toll-like_receptor_1	0,20	Toll-like receptor 4	Toll-like receptor 1	7099	7096	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Toll-like_receptor_1 inhibits Toll-like_receptor_4 signaling in endothelial cells .
11688988	0	Toll-like_receptor_4	28,48	Toll-like_receptor_4	71,91	Toll-like receptor 4	Toll-like receptor 4	7099	7099	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Heterogeneous expression of Toll-like_receptor_4 and downregulation of Toll-like_receptor_4 expression on human gingival fibroblasts by Porphyromonas_gingivalis lipopolysaccharide .
11688988	0	Toll-like_receptor_4	71,91	Toll-like_receptor_4	28,48	Toll-like receptor 4	Toll-like receptor 4	7099	7099	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Heterogeneous expression of Toll-like_receptor_4 and downregulation of Toll-like_receptor_4 expression on human gingival fibroblasts by Porphyromonas_gingivalis lipopolysaccharide .
12794153	0	Toll-like_receptor_4	131,151	Toll-like_receptor_5	110,130	Toll-like receptor 4	Toll-like receptor 5	21898(Tax:10090)	53791(Tax:10090)	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Induction of macrophage nitric_oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like_receptor_5 / Toll-like_receptor_4 complexes .
25093580	0	Toll-like_receptor_4	0,20	angiotensin_II	37,51	Toll-like receptor 4	angiotensin II	29260(Tax:10116)	24179(Tax:10116)	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Toll-like_receptor_4 upregulation by angiotensin_II contributes to hypertension and vascular_dysfunction through reactive oxygen species production .
16219107	0	Toll-like_receptor_4	37,57	beta-defensin_2	81,96	Toll-like receptor 4	beta-defensin 2	7099	1673	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Respiratory epithelial cells require Toll-like_receptor_4 for induction of human beta-defensin_2 by lipopolysaccharide .
18234118	0	Toll-like_receptor_4	55,75	heme_oxygenase-1	23,39	Toll-like receptor 4	heme oxygenase-1	7099	3162	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Association of reduced heme_oxygenase-1 with excessive Toll-like_receptor_4 expression in peripheral blood mononuclear cells in Beh et 's disease .
22217446	0	Toll-like_receptor_4	0,20	high-mobility_group_box_1	67,92	Toll-like receptor 4	high-mobility group box 1	21898(Tax:10090)	15289(Tax:10090)	Gene	Gene	senses|nsubj|START_ENTITY senses|advcl|END_ENTITY	Toll-like_receptor_4 on islet b cells senses expression changes in high-mobility_group_box_1 and contributes to the initiation of type 1 diabetes .
17068066	0	Toll-like_receptor_4	0,20	interleukin_10	216,230	Toll-like receptor 4	interleukin 10	21898(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY potentiates|nsubj|expression potentiates|parataxis|regulates regulates|nmod|END_ENTITY	Toll-like_receptor_4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis : Toll-like_receptor_4 largely regulates FcgammaR expression by interleukin_10 .
17068066	0	Toll-like_receptor_4	154,174	interleukin_10	216,230	Toll-like receptor 4	interleukin 10	21898(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Toll-like_receptor_4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis : Toll-like_receptor_4 largely regulates FcgammaR expression by interleukin_10 .
16283355	0	Toll-like_receptor_4	14,34	macrophage_migration_inhibitory_factor	64,102	Toll-like receptor 4	macrophage migration inhibitory factor	21898(Tax:10090)	17319(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of Toll-like_receptor_4 expression in mouse colon by macrophage_migration_inhibitory_factor .
24969711	0	Toll-like_receptor_4	28,48	myeloid_differentiation_factor_88	49,82	Toll-like receptor 4	myeloid differentiation factor 88	7099	4615	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|pathway pathway|amod|END_ENTITY	-LSB- Effects of sulforaphane on Toll-like_receptor_4 / myeloid_differentiation_factor_88 pathway of monocyte-derived macrophages from patients with chronic_obstructive_pulmonary_disease -RSB- .
24929539	0	Toll-like_receptor_4	66,86	stromal_cell-derived_factor-1	17,46	Toll-like receptor 4	stromal cell-derived factor-1	7099	6387	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Resistin-induced stromal_cell-derived_factor-1 expression through Toll-like_receptor_4 and activation of p38 MAPK / NFkB signaling pathway in gastric_cancer cells .
19912257	0	Toll-like_receptor_5	49,69	A20	0,3	Toll-like receptor 5	A20	7100	7128	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	A20 is an early responding negative regulator of Toll-like_receptor_5 signalling in intestinal epithelial cells during inflammation .
19303953	0	Toll-like_receptor_5	0,20	Ccl20	73,78	Toll-like receptor 5	Ccl20	53791(Tax:10090)	20297(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Toll-like_receptor_5 - and lymphotoxin_beta_receptor-dependent epithelial Ccl20 expression involves the same NF-kappaB binding site but distinct NF-kappaB pathways and dynamics .
23287987	0	Toll-like_receptor_5	0,20	TLR5	22,26	Toll-like receptor 5	TLR5	7100	7100	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Toll-like_receptor_5 -LRB- TLR5 -RRB- expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma_of_the_tongue .
12794153	0	Toll-like_receptor_5	110,130	Toll-like_receptor_4	131,151	Toll-like receptor 5	Toll-like receptor 4	53791(Tax:10090)	21898(Tax:10090)	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	Induction of macrophage nitric_oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like_receptor_5 / Toll-like_receptor_4 complexes .
15266299	0	Toll-like_receptor_6	0,20	TLR6	27,31	Toll-like receptor 6	TLR6	10333	10333	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Toll-like_receptor_6 gene -LRB- TLR6 -RRB- : single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma .
20070409	0	Toll-like_receptor_6	0,20	interleukin-17A	28,43	Toll-like receptor 6	interleukin-17A	21899(Tax:10090)	16171(Tax:10090)	Gene	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|amod|END_ENTITY	Toll-like_receptor_6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis .
19157556	0	Toll-like_receptor_7	0,20	IL-4	37,41	Toll-like receptor 7	IL-4	170743(Tax:10090)	16189(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Toll-like_receptor_7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production .
22952899	0	Toll-like_receptor_7	31,51	SIGIRR	101,107	Toll-like receptor 7	SIGIRR	51284	59307	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	The largely normal response to Toll-like_receptor_7 and 9 stimulation and the enhanced expression of SIGIRR by B cells in systemic_lupus_erythematosus .
19426145	0	Toll-like_receptor_7	104,124	TLR7	126,130	Toll-like receptor 7	TLR7	51284	51284	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	Nuclear factor kappaB -LRB- NF-kappaB -RRB- activation primes cells to a pro-inflammatory polarized response to a Toll-like_receptor_7 -LRB- TLR7 -RRB- agonist .
24782650	0	Toll-like_receptor_8	18,38	VEGF	65,69	Toll-like receptor 8	VEGF	51311	7422	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of Toll-like_receptor_8 and its relationship with VEGF and Bcl-2 in cervical_cancer .
26648480	0	Toll-like_receptor_9	27,47	Grancalcin	0,10	Toll-like receptor 9	Grancalcin	54106	25801	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Grancalcin -LRB- GCA -RRB- modulates Toll-like_receptor_9 -LRB- TLR9 -RRB- - mediated signaling through its direct interaction with TLR9 .
25681553	0	Toll-like_receptor_9	114,134	HMGB1	16,21	Toll-like receptor 9	HMGB1	81897(Tax:10090)	15289(Tax:10090)	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular_carcinoma through Toll-like_receptor_9 .
12573264	0	Toll-like_receptor_9	39,59	TLR9	66,70	Toll-like receptor 9	TLR9	54106	54106	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single-nucleotide polymorphisms in the Toll-like_receptor_9 gene -LRB- TLR9 -RRB- : frequencies , pairwise linkage disequilibrium , and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies .
17706295	0	Toll-like_receptor_9	16,36	TLR9	38,42	Toll-like receptor 9	TLR9	494547(Tax:9940)	494547(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of Toll-like_receptor_9 -LRB- TLR9 -RRB- gene in sheep .
22594374	0	Toll-like_receptor_9	0,20	TLR9	22,26	Toll-like receptor 9	TLR9	54106	54106	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Toll-like_receptor_9 -LRB- TLR9 -RRB- polymorphism associated with symptomatic malaria : a cohort study .
25576141	0	Toll-like_receptor_9	14,34	TLR9	36,40	Toll-like receptor 9	TLR9	397007(Tax:9823)	397007(Tax:9823)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Toll-like_receptor_9 -LRB- TLR9 -RRB- in the lungs and lymphoid tissue of pigs .
19258507	0	Toll-like_receptor_9	0,20	signal_transducer_and_activator_of_transcription_3	35,85	Toll-like receptor 9	signal transducer and activator of transcription 3	81897(Tax:10090)	20848(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Toll-like_receptor_9 activation of signal_transducer_and_activator_of_transcription_3 constrains its agonist-based immunotherapy .
15485822	0	Toll-like_receptor_9	0,20	tumor_necrosis_factor-alpha	31,58	Toll-like receptor 9	tumor necrosis factor-alpha	81897(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Toll-like_receptor_9 regulates tumor_necrosis_factor-alpha expression by different mechanisms .
21078852	0	Toll-like_receptors_1_and_2	100,127	CD4	71,74	Toll-like receptors 1 and 2	CD4	7096;7097	920	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Mycobacterium_tuberculosis lipoproteins directly regulate human memory CD4 -LRB- + -RRB- T cell activation via Toll-like_receptors_1_and_2 .
15857940	0	Toll-like_receptors_2_and_4	26,53	VIP	110,113	Toll-like receptors 2 and 4	VIP	7097;7099	7432	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Time-course expression of Toll-like_receptors_2_and_4 in inflammatory_bowel_disease and homeostatic effect of VIP .
21325271	0	Toll-like_receptors_2_and_4	111,138	bone_morphogenetic_protein-2	41,69	Toll-like receptors 2 and 4	bone morphogenetic protein-2	7097;7099	650	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Oxidized low density lipoprotein induces bone_morphogenetic_protein-2 in coronary artery endothelial cells via Toll-like_receptors_2_and_4 .
22622619	0	Toll-like_receptors_2_and_4	63,90	serum_amyloid_A	131,146	Toll-like receptors 2 and 4	serum amyloid A	7097;7099	6290	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Herpes_simplex_virus_type_1 induces simultaneous activation of Toll-like_receptors_2_and_4 and expression of the endogenous ligand serum_amyloid_A in astrocytes .
25008898	0	Toll-like_receptors_3_and_7	56,83	miR-758	104,111	Toll-like receptors 3 and 7	miR-758	7098;51284	768212	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Hepatitis_C virus infection decreases the expression of Toll-like_receptors_3_and_7 via upregulation of miR-758 .
17068331	0	Toll5A	32,38	toll	2,6	Toll5A	toll	5569408(Tax:7159)	43222(Tax:7227)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	A toll receptor and a cytokine , Toll5A and Spz1C , are involved in toll antifungal immune signaling in the mosquito Aedes_aegypti .
17068331	0	Toll5A	32,38	toll	66,70	Toll5A	toll	5569408(Tax:7159)	43222(Tax:7227)	Gene	Gene	receptor|appos|START_ENTITY involved|nsubjpass|receptor involved|advcl|signaling signaling|nsubj|END_ENTITY	A toll receptor and a cytokine , Toll5A and Spz1C , are involved in toll antifungal immune signaling in the mosquito Aedes_aegypti .
20109504	0	Toll_Like_Receptor_4	62,82	TLR4	84,88	Toll Like Receptor 4	TLR4	100066890(Tax:9796)	100066890(Tax:9796)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Bovine_papillomavirus_type_1 E2 and E7 proteins down-regulate Toll_Like_Receptor_4 -LRB- TLR4 -RRB- expression in equine fibroblasts .
22841886	0	Toll_like_receptor_4	36,56	High_mobility_group_box_1	0,25	Toll like receptor 4	High mobility group box 1	21898(Tax:10090)	15289(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	High_mobility_group_box_1 activates Toll_like_receptor_4 signaling in hepatic stellate cells .
21847628	0	Toll_receptor_3	38,53	Interleukin_29	0,14	Toll receptor 3	Interleukin 29	7098	282618	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin_29 enhances expression of Toll_receptor_3 and mediates antiviral signals in human keratinocytes .
25687760	0	Tollip	109,115	Ezh1	33,37	Tollip	Ezh1	54473(Tax:10090)	14055(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Promotes|dobj|Production Promotes|nsubj|END_ENTITY	Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip .
10854325	0	Tollip	0,6	IRAK	53,57	Tollip	IRAK	54472	3654	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	Tollip , a new component of the IL-1RI pathway , links IRAK to the IL-1 receptor .
22582869	0	Tollip	63,69	TLR4	31,35	Tollip	TLR4	54472	7099	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and localization of TLR4 and its negative regulator Tollip in the placenta of early-onset and late-onset preeclampsia .
23353651	0	Tollip	84,90	TLR4	31,35	Tollip	TLR4	54472	7099	Gene	Gene	expression|compound|START_ENTITY induced|nmod|expression signaling|acl|induced signaling|compound|END_ENTITY	Quercetin negatively regulates TLR4 signaling induced by lipopolysaccharide through Tollip expression .
25109435	0	Tollip	36,42	TLR4	111,115	Tollip	TLR4	54472	7099	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|negatively negatively|acl|regulating regulating|dobj|END_ENTITY	Epigallocatechin-3-gallate-mediated Tollip induction through the 67-kDa_laminin_receptor negatively regulating TLR4 signaling in endothelial cells .
26320582	0	Tollip	26,32	Tom1	0,4	Tollip	Tom1	54472	10043	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	Tom1 Modulates Binding of Tollip to Phosphatidylinositol_3-Phosphate via a Coupled Folding and Binding Mechanism .
26445490	0	Tollip	65,71	Tom1	14,18	Tollip	Tom1	54472	10043	Gene	Gene	Binding|nmod|START_ENTITY Tricks|nmod|Binding Tricks|compound|END_ENTITY	Time to Fold : Tom1 Uses New Tricks to Regulate Lipid Binding of Tollip .
22022271	0	Tollo	7,12	Toll-8	0,6	Tollo	Toll-8	44497(Tax:7227)	44497(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Toll-8 / Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium .
10704876	0	Tolloid	26,33	BMP-1	20,25	Tolloid	BMP-1	414883(Tax:9031)	414883(Tax:9031)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of chick BMP-1 / Tolloid during patterning of the neural tube and somites .
19366374	0	Tolloid-like_1	14,28	Nkx2-5	83,89	Tolloid-like 1	Nkx2-5	7092	1482	Gene	Gene	expression|compound|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of Tolloid-like_1 gene expression by the cardiac specific homeobox gene Nkx2-5 .
26320582	0	Tom1	0,4	Tollip	26,32	Tom1	Tollip	10043	54472	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Tom1 Modulates Binding of Tollip to Phosphatidylinositol_3-Phosphate via a Coupled Folding and Binding Mechanism .
26445490	0	Tom1	14,18	Tollip	65,71	Tom1	Tollip	10043	54472	Gene	Gene	Tricks|compound|START_ENTITY Tricks|nmod|Binding Binding|nmod|END_ENTITY	Time to Fold : Tom1 Uses New Tricks to Regulate Lipid Binding of Tollip .
14563850	0	Tom1	0,4	tollip	54,60	Tom1	tollip	10043	54472	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tom1 , a VHS domain-containing protein , interacts with tollip , ubiquitin , and clathrin .
11913975	0	Tom20	13,18	Tom34	0,5	Tom20	Tom34	9804	10953	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins .
22198199	0	Tom22	30,35	Bax	52,55	Tom22	Bax	56993	581	Gene	Gene	domain|nmod|START_ENTITY modulates|nsubj|domain modulates|dobj|translocation translocation|compound|END_ENTITY	The cytosolic domain of human Tom22 modulates human Bax mitochondrial translocation and conformation in yeast .
11913975	0	Tom34	0,5	Tom20	13,18	Tom34	Tom20	10953	9804	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins .
20668160	0	Tom40	95,100	Tom5	62,66	Tom40	Tom5	10452	401505	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Assembly of the mitochondrial protein import channel : role of Tom5 in two-stage interaction of Tom40 with the SAM complex .
20668160	0	Tom5	62,66	Tom40	95,100	Tom5	Tom40	401505	10452	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Assembly of the mitochondrial protein import channel : role of Tom5 in two-stage interaction of Tom40 with the SAM complex .
24614299	0	Tomosyn	0,7	PIASy	42,47	Tomosyn	PIASy	134957	51588	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tomosyn interacts with the SUMO E3 ligase PIASy .
12832401	0	Tomosyn	0,7	syntaxin4	36,45	Tomosyn	syntaxin4	134957	6810	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation .
17440116	0	TonEBP	71,77	cytochrome_P450_2E1	14,33	TonEBP	cytochrome P450 2E1	10725	1571	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cytochrome_P450_2E1 under hypertonic environment through TonEBP in human hepatocytes .
15142033	0	TonEBP	94,100	taurine_transporter	14,33	TonEBP	taurine transporter	10725	6533	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of taurine_transporter is regulated through the TonE -LRB- tonicity-responsive element -RRB- / TonEBP -LRB- TonE-binding_protein -RRB- pathway and contributes to cytoprotection in HepG2 cells .
16641150	0	Tonicity-responsive_enhancer_binding_protein	0,44	aquaporin-2	74,85	Tonicity-responsive enhancer binding protein	aquaporin-2	54446(Tax:10090)	11827(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Tonicity-responsive_enhancer_binding_protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells .
19279141	0	TopBP1	52,58	ATM	62,65	TopBP1	ATM	398573(Tax:8355)	398148(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nmod|END_ENTITY	The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM .
16880517	0	TopBP1	31,37	ATR	48,51	TopBP1	ATR	11073	545	Gene	Gene	downstream|nmod|START_ENTITY operates|dobj|downstream operates|xcomp|direct direct|dobj|END_ENTITY	Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation .
17446169	0	TopBP1	98,104	ATR	60,63	TopBP1	ATR	398573(Tax:8355)	398197(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY occurs|nmod|phosphorylation activation|acl:relcl|occurs activation|nmod|END_ENTITY	Ataxia-telangiectasia_mutated -LRB- ATM -RRB- - dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM .
18519633	0	TopBP1	18,24	ATR	4,7	TopBP1	ATR	11073	545	Gene	Gene	goes|nsubj|START_ENTITY goes|advcl|turns turns|nsubj|END_ENTITY	How ATR turns on : TopBP1 goes on ATRIP with ATR .
18519633	0	TopBP1	18,24	ATR	44,47	TopBP1	ATR	11073	545	Gene	Gene	goes|nsubj|START_ENTITY goes|nmod|END_ENTITY	How ATR turns on : TopBP1 goes on ATRIP with ATR .
18519640	0	TopBP1	0,6	ATR	17,20	TopBP1	ATR	11073	545	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain .
19652550	0	TopBP1	0,6	ATR	163,166	TopBP1	ATR	11073	545	Gene	Gene	recruitment|amod|START_ENTITY recruitment|dep|implications implications|nmod|mechanism mechanism|nmod|activation activation|compound|END_ENTITY	TopBP1 and DNA_polymerase_alpha-mediated recruitment of the 9-1-1 complex to stalled replication forks : implications for a replication restart-based mechanism for ATR checkpoint activation .
21502314	0	TopBP1	90,96	ATR	175,178	TopBP1	ATR	11073	545	Gene	Gene	proteins|dep|START_ENTITY activates|nsubj|proteins activates|dobj|phosphorylation phosphorylation|appos|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
21659603	0	TopBP1	59,65	ATR	99,102	TopBP1	ATR	11073	545	Gene	Gene	protein|amod|START_ENTITY protein|acl|required required|nmod|signaling signaling|compound|END_ENTITY	A DNA damage response screen identifies RHINO , a 9-1-1 and TopBP1 interacting protein required for ATR signaling .
26695634	0	TopBP1	75,81	ATR	104,107	TopBP1	ATR	11073	545	Gene	Gene	Transcription|appos|START_ENTITY Gene|nsubj|Transcription Gene|xcomp|Activate Activate|dobj|Pathway Pathway|compound|END_ENTITY	STAT-5 Regulates Transcription of the Topoisomerase IIb-Binding Protein 1 -LRB- TopBP1 -RRB- Gene To Activate the ATR Pathway and Promote Human_Papillomavirus Replication .
18519633	0	TopBP1	18,24	ATRIP	33,38	TopBP1	ATRIP	11073	84126	Gene	Gene	goes|nsubj|START_ENTITY goes|nmod|END_ENTITY	How ATR turns on : TopBP1 goes on ATRIP with ATR .
18519640	0	TopBP1	0,6	ATRIP	29,34	TopBP1	ATRIP	11073	84126	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	TopBP1 activates ATR through ATRIP and a PIKK regulatory domain .
24239288	0	TopBP1	0,6	BLM	16,19	TopBP1	BLM	11073	641	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|level level|compound|END_ENTITY	TopBP1 controls BLM protein level to maintain genome stability .
12697828	0	TopBP1	53,59	E2F1	14,18	TopBP1	E2F1	11073	1869	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of E2F1 by BRCT domain-containing protein TopBP1 .
21482717	0	TopBP1	23,29	MDC1	0,4	TopBP1	MDC1	11073	9656	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	MDC1 collaborates with TopBP1 in DNA replication checkpoint control .
20116089	0	TopBP1	26,32	Treslin	0,7	TopBP1	Treslin	11073	90381	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	Treslin collaborates with TopBP1 in triggering the initiation of DNA replication .
23333389	0	TopBP1	44,50	WDR18	20,25	TopBP1	WDR18	11073	57418	Gene	Gene	collaborates|nmod|START_ENTITY collaborates|nsubj|END_ENTITY	WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling .
23277395	0	TopBP1	91,97	topoisomerase_IIb_binding_protein_1	54,89	TopBP1	topoisomerase IIb binding protein 1	11073	11073	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between the c. * 229C > T polymorphism of the topoisomerase_IIb_binding_protein_1 -LRB- TopBP1 -RRB- gene and breast_cancer .
27017547	0	TopI	85,89	topoisomerase_I	68,83	TopI	topoisomerase I	7150	7150	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and biological evaluation of indeno -LSB- 1,5 -RSB- naphthyridines as topoisomerase_I -LRB- TopI -RRB- inhibitors with antiproliferative activity .
19821153	0	Topors	24,30	Plk1	0,4	Topors	Plk1	10210	5347	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Plk1 phosphorylation of Topors is involved in its degradation .
16055732	0	Tor2	0,4	Ypk2	44,48	Tor2	Ypk2	853632(Tax:4932)	855130(Tax:4932)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization .
22675200	0	Toso	0,4	IL-2	49,53	Toso	IL-2	9214	3558	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Toso , a functional IgM receptor , is regulated by IL-2 in T and NK cells .
19084934	0	Tp53	17,21	C-myc	23,28	Tp53	C-myc	7157	4609	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Tissue array for Tp53 , C-myc , CCND1 gene over-expression in different tumors .
19084934	0	Tp53	17,21	CCND1	30,35	Tp53	CCND1	7157	595	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Tissue array for Tp53 , C-myc , CCND1 gene over-expression in different tumors .
16954602	0	Tpc1808	0,7	NF-H	32,36	Tpc1808	NF-H	64560(Tax:10116)	24587(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Tpc1808 increases expression of NF-H in PC12 cells .
11932422	0	Tpl-2	29,34	Cot	35,38	Tpl-2	Cot	1326	1326	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|END_ENTITY	The oncogenic protein kinase Tpl-2 / Cot contributes to Epstein-Barr_virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2 .
9840924	0	Tpl-2	0,5	IL-2	14,18	Tpl-2	IL-2	1326	3558	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB .
12881420	0	Tpl2	0,4	CD40	16,20	Tpl2	CD40	26410(Tax:10090)	21939(Tax:10090)	Gene	Gene	transduces|nsubj|START_ENTITY transduces|dobj|signals signals|compound|END_ENTITY	Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40 .
15778223	0	Tpl2	0,4	tumor_progression_locus_2	6,31	Tpl2	tumor progression locus 2	1326	1326	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Tpl2 -LRB- tumor_progression_locus_2 -RRB- phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B_Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals .
14720445	0	Tpo	11,14	IL-11	22,27	Tpo	IL-11	7173	3589	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Effect of Tpo and/or IL-11 gene modified stromal cells on the expansion of CD34 + CD38 - hematopoietic primitive progenitor cells -RSB- .
20236022	0	Tpo	40,43	thrombopoietin	24,38	Tpo	thrombopoietin	81811(Tax:10116)	81811(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inflammation stimulates thrombopoietin -LRB- Tpo -RRB- expression in rat brain-derived microvascular endothelial cells , but suppresses Tpo in astrocytes and microglia .
22101936	0	Tpp1	40,44	Rnf8	24,28	Tpp1	Rnf8	1200	9025	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection .
23355470	0	Tppp1	44,49	Tubulin_polymerization_promoting_protein_1	0,42	Tppp1	Tubulin polymerization promoting protein 1	11076	11076	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Tubulin_polymerization_promoting_protein_1 -LRB- Tppp1 -RRB- phosphorylation by Rho-associated coiled-coil kinase -LRB- rock -RRB- and cyclin-dependent_kinase 1 -LRB- Cdk1 -RRB- inhibits microtubule dynamics to increase cell proliferation .
18981471	0	Tpr	0,3	Mad1	22,26	Tpr	Mad1	7175	4084	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint .
24563354	0	Tpr	25,28	nucleoporin	13,24	Tpr	nucleoporin	7175	3268	Gene	Gene	START_ENTITY|nsubj|Roles Roles|nmod|END_ENTITY	Roles of the nucleoporin Tpr in cancer and aging .
17442571	0	Tpt1	0,4	oct4	32,36	Tpt1	oct4	7178	5460	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei .
25665281	0	TrKB	72,76	brain_derivated_neurotrophic_factor	14,49	TrKB	brain derivated neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of brain_derivated_neurotrophic_factor and of its receptors : TrKB and p75NT in normal and bile duct ligated rat liver .
10749975	0	Tra2beta	88,96	RBMY	0,4	Tra2beta	RBMY	6434	5940	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	RBMY , a probable human spermatogenesis factor , and other hnRNP_G proteins interact with Tra2beta and affect splicing .
9324263	0	TraD	77,81	TraM	36,40	TraD	TraM	5892	23471	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The cytoplasmic DNA-binding protein TraM binds to the inner membrane protein TraD in vitro .
9324263	0	TraM	36,40	TraD	77,81	TraM	TraD	23471	5892	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The cytoplasmic DNA-binding protein TraM binds to the inner membrane protein TraD in vitro .
10564472	0	TraM	45,49	TraR	65,69	TraM	TraR	1224219(Tax:358)	6382029(Tax:358)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Modulating quorum sensing by antiactivation : TraM interacts with TraR to inhibit activation of Ti plasmid conjugal transfer genes .
15044488	0	TraM	48,52	TraR	108,112	TraM	TraR	1224219(Tax:358)	6382029(Tax:358)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of the quorum-sensing protein TraM and its interaction with the transcriptional regulator TraR .
10564472	0	TraR	65,69	TraM	45,49	TraR	TraM	6382029(Tax:358)	1224219(Tax:358)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Modulating quorum sensing by antiactivation : TraM interacts with TraR to inhibit activation of Ti plasmid conjugal transfer genes .
15044488	0	TraR	108,112	TraM	48,52	TraR	TraM	6382029(Tax:358)	1224219(Tax:358)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of the quorum-sensing protein TraM and its interaction with the transcriptional regulator TraR .
17234899	0	Trace_amine-associated_receptor_1	0,33	dopamine_transporter	56,76	Trace amine-associated receptor 1	dopamine transporter	708944(Tax:9544)	574143(Tax:9544)	Gene	Gene	modulator|nsubj|START_ENTITY modulator|nmod|END_ENTITY	Trace_amine-associated_receptor_1 is a modulator of the dopamine_transporter .
12506002	0	Tracheae_Defective	38,56	MBF1	11,15	Tracheae Defective	MBF1	37734(Tax:7227)	39842(Tax:7227)	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	Drosophila MBF1 is a co-activator for Tracheae_Defective and contributes to the formation of tracheal and nervous systems .
18056447	0	Traf1	0,5	tumor_necrosis_factor	36,57	Traf1	tumor necrosis factor	7185	7124	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Traf1 induction and protection from tumor_necrosis_factor by nuclear factor-kappaB p65 is independent of serine 536 phosphorylation .
15175328	0	Traf2	165,170	Rip1	23,27	Traf2	Rip1	22030(Tax:10090)	19766(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|activity activity|nmod|END_ENTITY	The kinase activity of Rip1 is not required for tumor_necrosis_factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2 .
19836350	0	Traf2	0,5	Smad4	21,26	Traf2	Smad4	22030(Tax:10090)	17128(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Traf2 interacts with Smad4 and regulates BMP signaling pathway in MC3T3-E1 osteoblasts .
16969126	0	Traf4	65,70	p53	85,88	Traf4	p53	9618	7157	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	Identification and characterization of proteins interacting with Traf4 , an enigmatic p53 target .
21660951	0	Trail	0,5	osteoprotegerin	36,51	Trail	osteoprotegerin	8743	4982	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|release release|nmod|END_ENTITY	Trail down-regulates the release of osteoprotegerin -LRB- OPG -RRB- by primary stromal cells .
26986145	0	Transcription_Factor_7_Like_2	19,48	TCF7L2	50,56	Transcription Factor 7 Like 2	TCF7L2	6934	6934	Gene	Gene	Polymorphism|compound|START_ENTITY Polymorphism|appos|END_ENTITY	Association of the Transcription_Factor_7_Like_2 -LRB- TCF7L2 -RRB- Polymorphism With Diabetic_Nephropathy Risk : A Meta-Analysis .
20803090	0	Transcription_factor_7-like_2	0,29	Smad1	87,92	Transcription factor 7-like 2	Smad1	6934	4086	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- regulates activin_receptor-like_kinase_1 -LRB- ALK1 -RRB- / Smad1 pathway for development of diabetic_nephropathy .
18931037	0	Transcription_factor_7-like_2	0,29	TCF7L2	31,37	Transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults : the Atherosclerosis Risk in Communities study .
20578204	0	Transcription_factor_7-like_2	0,29	TCF7L2	31,37	Transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- polymorphism and context-specific risk of impaired_fasting_glucose in African American and Caucasian adults : the atherosclerosis risk in communities -LRB- ARIC -RRB- study .
24529562	0	Transcription_factor_7-like_2	0,29	TCF7L2	31,37	Transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration .
7876223	0	Transcription_factor_GATA-1	0,27	HOXB2	44,49	Transcription factor GATA-1	HOXB2	2623	3212	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Transcription_factor_GATA-1 regulates human HOXB2 gene expression in erythroid cells .
21127351	0	Transcription_factor_IIS	0,24	UBR5	55,59	Transcription factor IIS	UBR5	6920	51366	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Transcription_factor_IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B. Elongation of transcription by mammalian RNA polymerase II -LRB- RNAPII -RRB- is regulated by specific factors , including transcription_factor_IIS -LRB- TFIIS -RRB- and positive transcription elongation factor b -LRB- P-TEFb -RRB- .
10899165	0	Transcription_factor_ZBP-89	0,27	p300	70,74	Transcription factor ZBP-89	p300	7707	2033	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Transcription_factor_ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells .
18177740	0	Transcriptional_enhancer_factor_1	0,33	BRGl	86,90	Transcriptional enhancer factor 1	BRGl	7003	81616	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Transcriptional_enhancer_factor_1 -LRB- TEF-1 / TEAD1 -RRB- mediates activation of IFITM3 gene by BRGl .
9874198	0	Transducin-like_Enhancer_of_split_2	0,35	Groucho	73,80	Transducin-like Enhancer of split 2	Groucho	7089	43162(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Transducin-like_Enhancer_of_split_2 , a mammalian homologue of Drosophila Groucho , acts as a transcriptional repressor , interacts with Hairy/Enhancer _ of_split proteins , and is expressed during neuronal development .
7076068	0	Transferrin	0,11	Tf	13,15	Transferrin	Tf	7018	7018	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Transferrin -LRB- Tf -RRB- polymorphism : an analysis by isoelectric focusing .
18835036	0	Transferrin	0,11	interleukin-18	20,34	Transferrin	interleukin-18	7018	3606	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Transferrin induces interleukin-18 expression in chronic_myeloid_leukemia cell line , K-562 .
8675172	0	Transferrin	0,11	transferrin	52,63	Transferrin	transferrin	7018	7018	Gene	Gene	uptake|amod|START_ENTITY uptake|nmod|END_ENTITY	Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression .
10318901	0	Transferrin_receptor	0,20	HFE	76,79	Transferrin receptor	HFE	7037	3077	Gene	Gene	modulated|nsubjpass|START_ENTITY modulated|nmod|END_ENTITY	Transferrin_receptor is negatively modulated by the hemochromatosis protein HFE : implications for cellular iron homeostasis .
17495453	0	Transferrin_receptor	0,20	IgA1	45,49	Transferrin receptor	IgA1	7037	3493	Gene	Gene	engagement|amod|START_ENTITY engagement|nmod|END_ENTITY	Transferrin_receptor engagement by polymeric IgA1 induces receptor expression and mesangial cell proliferation : role in IgA nephropathy .
3013349	0	Transferrin_receptor	0,20	estrogen_receptor	50,67	Transferrin receptor	estrogen receptor	7037	2099	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	Transferrin_receptor is inversely correlated with estrogen_receptor in breast_cancer .
20634490	0	Transferrin_receptor_2	0,22	furin	40,45	Transferrin receptor 2	furin	50765(Tax:10090)	18550(Tax:10090)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Transferrin_receptor_2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular _ signal-regulated_kinase -LRB- MAPK/Erk -RRB- signaling .
25326845	0	Transforming_Growth_Factor-Beta1	97,129	Smad3	130,135	Transforming Growth Factor-Beta1	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Vitamin_D Prevents the Intestinal Fibrosis Via Induction of Vitamin_D Receptor and Inhibition of Transforming_Growth_Factor-Beta1 / Smad3 Pathway .
26458764	0	Transforming_Growth_Factor-b	39,67	CLOCK	10,15	Transforming Growth Factor-b	CLOCK	21803(Tax:10090)	12753(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY Activation|nmod|Signaling END_ENTITY|dobj|Activation	Circadian CLOCK Mediates Activation of Transforming_Growth_Factor-b Signaling and Renal Fibrosis through Cyclooxygenase_2 .
24723976	0	Transforming_Growth_Factor-b	92,120	Estrogen_Receptor_a	135,154	Transforming Growth Factor-b	Estrogen Receptor a	7040	2099	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Identification of a Novel Compound That Suppresses Breast_Cancer Invasiveness by Inhibiting Transforming_Growth_Factor-b Signaling via Estrogen_Receptor_a .
25269071	0	Transforming_Growth_Factor-b	0,28	TGF-b	30,35	Transforming Growth Factor-b	TGF-b	7040	7040	Gene	Gene	Expression|amod|START_ENTITY Expression|appos|END_ENTITY	Transforming_Growth_Factor-b -LRB- TGF-b -RRB- Expression Is Increased in the Subsynovial Connective Tissue in a Rabbit Model of Carpal_Tunnel_Syndrome .
25910219	0	Transforming_Growth_Factor_Beta-Induced	15,54	TGFBIp	64,70	Transforming Growth Factor Beta-Induced	TGFBIp	7045	7045	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Fibril Core of Transforming_Growth_Factor_Beta-Induced Protein -LRB- TGFBIp -RRB- Facilitates Aggregation of Corneal TGFBIp .
25890570	0	Transforming_Growth_Factor_Beta_Receptor_II	57,100	Androgen_Receptor	4,21	Transforming Growth Factor Beta Receptor II	Androgen Receptor	7048	367	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Re : Androgen_Receptor and MicroRNA-21 Axis Downregulates Transforming_Growth_Factor_Beta_Receptor_II -LRB- TGFBR2 -RRB- Expression in Prostate_Cancer .
25890570	0	Transforming_Growth_Factor_Beta_Receptor_II	57,100	TGFBR2	102,108	Transforming Growth Factor Beta Receptor II	TGFBR2	7048	7048	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Re : Androgen_Receptor and MicroRNA-21 Axis Downregulates Transforming_Growth_Factor_Beta_Receptor_II -LRB- TGFBR2 -RRB- Expression in Prostate_Cancer .
25284780	0	Transforming_Growth_Factor_b	0,28	Activin	29,36	Transforming Growth Factor b	Activin	37778(Tax:7227)	43826(Tax:7227)	Gene	Gene	START_ENTITY|dep|Functions Functions|compound|END_ENTITY	Transforming_Growth_Factor_b / Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression .
25869072	0	Transforming_growth_factor-a	0,28	E-cadherin	91,101	Transforming growth factor-a	E-cadherin	7124	999	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Transforming_growth_factor-a induces human ovarian_cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner .
7727772	0	Transforming_growth_factor-alpha	0,32	TGF-alpha	84,93	Transforming growth factor-alpha	TGF-alpha	7124	7039	Gene	Gene	START_ENTITY|dep|demonstration demonstration|nmod|END_ENTITY	Transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in human bone marrow : demonstration of TGF-alpha in erythroblasts and eosinophilic precursor cells and of epidermal_growth_factor receptors in blastlike cells of myelomonocytic origin .
8560658	0	Transforming_growth_factor-alpha	0,32	TGF-alpha	75,84	Transforming growth factor-alpha	TGF-alpha	7124	7039	Gene	Gene	expression|amod|START_ENTITY expression|dep|expression expression|amod|END_ENTITY	Transforming_growth_factor-alpha expression in human renal_cell_carcinoma : TGF-alpha expression in renal_cell_carcinoma .
9052515	0	Transforming_growth_factor-alpha	0,32	TGF-alpha	34,43	Transforming growth factor-alpha	TGF-alpha	7124	7039	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- levels in human proximal gastrointestinal epithelium .
8404616	0	Transforming_growth_factor-alpha	0,32	TGF_alpha	34,43	Transforming growth factor-alpha	TGF alpha	24827(Tax:10116)	24827(Tax:10116)	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- concentrations increase in regenerating rat liver : evidence for a delayed accumulation of mature TGF_alpha .
8426908	0	Transforming_growth_factor-alpha	0,32	TGF_alpha	34,43	Transforming growth factor-alpha	TGF alpha	7124	7039	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- inhibition of parietal cell secretion : structural requirements for activity .
22407503	0	Transforming_growth_factor-alpha	0,32	endothelin_receptor_A	41,62	Transforming growth factor-alpha	endothelin receptor A	24827(Tax:10116)	24326(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-alpha induces endothelin_receptor_A expression in osteoarthritis .
2422759	0	Transforming_growth_factor-alpha	0,32	epidermal_growth_factor	73,96	Transforming growth factor-alpha	epidermal growth factor	7124	1950	Gene	Gene	START_ENTITY|dep|mediator mediator|nmod|END_ENTITY	Transforming_growth_factor-alpha : a more potent angiogenic mediator than epidermal_growth_factor .
10027766	0	Transforming_growth_factor-alpha	0,32	epidermal_growth_factor_receptor	47,79	Transforming growth factor-alpha	epidermal growth factor receptor	24827(Tax:10116)	24329(Tax:10116)	Gene	Gene	acting|amod|START_ENTITY acting|nmod|END_ENTITY	Transforming_growth_factor-alpha acting at the epidermal_growth_factor_receptor reduces infarct volume after permanent middle_cerebral_artery_occlusion in rats .
10082132	0	Transforming_growth_factor-alpha	0,32	epidermal_growth_factor_receptor	70,102	Transforming growth factor-alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Transforming_growth_factor-alpha short-circuits downregulation of the epidermal_growth_factor_receptor .
1805786	0	Transforming_growth_factor-alpha	0,32	epidermal_growth_factor_receptor	46,78	Transforming growth factor-alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Transforming_growth_factor-alpha binds to the epidermal_growth_factor_receptor in gastric mucosa .
8453634	0	Transforming_growth_factor-alpha	0,32	epidermal_growth_factor_receptor	123,155	Transforming growth factor-alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	production|amod|START_ENTITY production|nmod|gene gene|compound|END_ENTITY	Transforming_growth_factor-alpha production and autoinduction in a colorectal_carcinoma cell line -LRB- DiFi -RRB- with an amplified epidermal_growth_factor_receptor gene .
9127315	0	Transforming_growth_factor-alpha	0,32	epidermal_growth_factor_receptor	34,66	Transforming growth factor-alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-alpha , epidermal_growth_factor_receptor , and MiB-1 expression in Barrett 's - associated neoplasia : correlation with prognosis .
16857964	0	Transforming_growth_factor-alpha	0,32	nuclear_factor_kappaB	42,63	Transforming growth factor-alpha	nuclear factor kappaB	21802(Tax:10090)	18033(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Transforming_growth_factor-alpha mediates nuclear_factor_kappaB activation in strained arteries .
26224478	0	Transforming_growth_factor-b	0,28	ERa	66,69	Transforming growth factor-b	ERa	7040	26284	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Transforming_growth_factor-b signaling pathway cross-talking with ERa signaling pathway on regulating the growth of uterine_leiomyoma activated by phenolic environmental estrogens in vitro .
22521802	0	Transforming_growth_factor-b	0,28	Smad3	93,98	Transforming growth factor-b	Smad3	59086(Tax:10116)	25631(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY vascular|nsubj|increases vascular|nmod|END_ENTITY	Transforming_growth_factor-b increases vascular smooth muscle cell proliferation through the Smad3 and extracellular_signal-regulated_kinase mitogen-activated protein kinases pathways .
24014274	0	Transforming_growth_factor-b	0,28	TGF-b	30,35	Transforming growth factor-b	TGF-b	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor-b -LRB- TGF-b -RRB- expression is increased in the subsynovial connective tissues of patients with idiopathic carpal_tunnel_syndrome .
22287612	0	Transforming_growth_factor-b	0,28	endothelin-1	39,51	Transforming growth factor-b	endothelin-1	21803(Tax:10090)	13614(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Transforming_growth_factor-b regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure .
23182613	0	Transforming_growth_factor-b	0,28	vimentin	49,57	Transforming growth factor-b	vimentin	7040	7431	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-b transiently induces vimentin expression and invasive capacity in a canine mammary gland tumor cell line .
24629065	0	Transforming_growth_factor-b1	0,29	NADPH_oxidase_4	39,54	Transforming growth factor-b1	NADPH oxidase 4	21803(Tax:10090)	50490(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Transforming_growth_factor-b1 requires NADPH_oxidase_4 for angiogenesis in vitro and in vivo .
23248240	0	Transforming_growth_factor-b1	0,29	Slug	167,171	Transforming growth factor-b1	Slug	7040	6591	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Transforming_growth_factor-b1 induces epithelial-mesenchymal transition and integrin a3b1-mediated cell migration of HSC-4 human squamous cell carcinoma cells through Slug .
22307228	0	Transforming_growth_factor-b1	0,29	glutathione_peroxidase-1	38,62	Transforming growth factor-b1	glutathione peroxidase-1	7040	2876	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Transforming_growth_factor-b1 induces glutathione_peroxidase-1 and protects from H2O2-induced cell death in colon_cancer cells via the Smad2/ERK1/2 / HIF-1a pathway .
23657814	0	Transforming_growth_factor-b1	0,29	hepatocyte_growth_factor	51,75	Transforming growth factor-b1	hepatocyte growth factor	7040	3082	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-b1 selectively inhibits hepatocyte_growth_factor expression via a micro-RNA-199-dependent posttranscriptional mechanism .
22647687	0	Transforming_growth_factor-b1	0,29	junctional_adhesion_molecule-A	41,71	Transforming growth factor-b1	junctional adhesion molecule-A	7040	50848	Gene	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Transforming_growth_factor-b1 attenuates junctional_adhesion_molecule-A and contributes to breast_cancer cell invasion .
21518085	0	Transforming_growth_factor-b1	0,29	tumor_necrosis_factor-a	124,147	Transforming growth factor-b1	tumor necrosis factor-a	59086(Tax:10116)	24835(Tax:10116)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Transforming_growth_factor-b1 suppresses the up-regulation of matrix_metalloproteinase-2 by lung fibroblasts in response to tumor_necrosis_factor-a .
12646579	0	Transforming_growth_factor-beta	0,31	ADAMTS-2	63,71	Transforming growth factor-beta	ADAMTS-2	7040	9509	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Transforming_growth_factor-beta induces secretion of activated ADAMTS-2 .
15465036	0	Transforming_growth_factor-beta	0,31	ANF	58,61	Transforming growth factor-beta	ANF	7040	4878	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK .
7683321	0	Transforming_growth_factor-beta	0,31	E-selectin	41,51	Transforming growth factor-beta	E-selectin	7040	6401	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta inhibits E-selectin expression on human endothelial cells .
17884818	0	Transforming_growth_factor-beta	0,31	Fli1	87,91	Transforming growth factor-beta	Fli1	7040	2313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Transforming_growth_factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation .
8468489	0	Transforming_growth_factor-beta	0,31	IL-1_receptor_antagonist	69,93	Transforming growth factor-beta	IL-1 receptor antagonist	7040	3557	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Transforming_growth_factor-beta mediates IL-1-dependent induction of IL-1_receptor_antagonist .
8186198	0	Transforming_growth_factor-beta	0,31	IL-4	41,45	Transforming growth factor-beta	IL-4	7040	3565	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Transforming_growth_factor-beta inhibits IL-4 and IFN-gamma production by stimulated human T cells .
14751563	0	Transforming_growth_factor-beta	0,31	RANKL	79,84	Transforming growth factor-beta	RANKL	7040	8600	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|absence absence|nmod|END_ENTITY	Transforming_growth_factor-beta induces osteoclast formation in the absence of RANKL .
12161428	0	Transforming_growth_factor-beta	0,31	SMAD3	99,104	Transforming growth factor-beta	SMAD3	7040	4088	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|interactions interactions|nummod|END_ENTITY	Transforming_growth_factor-beta inhibits pulmonary surfactant_protein_B gene transcription through SMAD3 interactions with NKX2 .1 and HNF-3 transcription factors .
17881189	0	Transforming_growth_factor-beta	0,31	SMAD3	60,65	Transforming growth factor-beta	SMAD3	7040	4088	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|telomerase telomerase|nmod|factors factors|compound|END_ENTITY	Transforming_growth_factor-beta inhibits telomerase through SMAD3 and E2F transcription factors .
11294908	0	Transforming_growth_factor-beta	0,31	Smad3	58,63	Transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|import import|nmod|END_ENTITY	Transforming_growth_factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner .
19265200	0	Transforming_growth_factor-beta	0,31	Smad3	32,37	Transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Transforming_growth_factor-beta / Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function .
14992427	0	Transforming_growth_factor-beta	0,31	TGF-beta	33,41	Transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- protein levels are not elevated in the blood or bile of patients with primary_sclerosing_cholangitis : a pilot study .
15041079	0	Transforming_growth_factor-beta	0,31	TGF-beta	169,177	Transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- - resistant B cells from chronic_lymphocytic_leukemia patients contain recurrent mutations in the signal sequence of the type I TGF-beta receptor .
8697616	0	Transforming_growth_factor-beta	0,31	TGF-beta	33,41	Transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- expression and interaction with proteinase_3 -LRB- PR3 -RRB- in anti-neutrophil cytoplasmic antibody -LRB- ANCA -RRB- - associated vasculitis .
15465036	0	Transforming_growth_factor-beta	0,31	ZAK	127,130	Transforming growth factor-beta	ZAK	7040	51776	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Transforming_growth_factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK .
15546867	0	Transforming_growth_factor-beta	0,31	biglycan	134,142	Transforming growth factor-beta	biglycan	7040	633	Gene	Gene	type|amod|START_ENTITY type|dep|I I|acl:relcl|mediates mediates|dobj|induction induction|nmod|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta .
9228090	0	Transforming_growth_factor-beta	0,31	bone_morphogenetic_protein-1	46,74	Transforming growth factor-beta	bone morphogenetic protein-1	7040	649	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Transforming_growth_factor-beta regulation of bone_morphogenetic_protein-1 / procollagen_C-proteinase and related proteins in fibrogenic cells and keratinocytes .
17300978	0	Transforming_growth_factor-beta	0,31	connective_tissue_growth_factor	32,63	Transforming growth factor-beta	connective tissue growth factor	7040	1490	Gene	Gene	START_ENTITY|parataxis|axis axis|nsubj|END_ENTITY	Transforming_growth_factor-beta / connective_tissue_growth_factor axis in the kidney .
11804868	0	Transforming_growth_factor-beta	0,31	elastin	43,50	Transforming growth factor-beta	elastin	7040	2006	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|compound|END_ENTITY	Transforming_growth_factor-beta stabilizes elastin mRNA by a pathway requiring active Smads , protein_kinase_C-delta , and p38 .
1573852	0	Transforming_growth_factor-beta	0,31	elastin	45,52	Transforming growth factor-beta	elastin	7040	2006	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Transforming_growth_factor-beta up-regulates elastin gene expression in human skin fibroblasts .
15838328	0	Transforming_growth_factor-beta	0,31	endothelin-1	40,52	Transforming growth factor-beta	endothelin-1	7040	1906	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta induces endothelin-1 expression through activation of the Smad signaling pathway .
9681709	0	Transforming_growth_factor-beta	0,31	endothelin-1	33,45	Transforming growth factor-beta	endothelin-1	7040	1906	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-beta , endothelin-1 , and c-fos expression in necrotizing/crescentic IgA glomerulonephritis .
8923854	0	Transforming_growth_factor-beta	0,31	enkephalinase	62,75	Transforming growth factor-beta	enkephalinase	7040	4311	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta inhibits progesterone-induced enkephalinase expression in human endometrial stromal cells .
12525871	0	Transforming_growth_factor-beta	0,31	interferon-gamma	97,113	Transforming growth factor-beta	interferon-gamma	7040	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Transforming_growth_factor-beta released by PPD-presenting malignant_mesothelioma cells inhibits interferon-gamma synthesis by an anti-PPD CD4 + T-cell clone .
15852008	0	Transforming_growth_factor-beta	0,31	interferon-gamma	116,132	Transforming growth factor-beta	interferon-gamma	7040	3458	Gene	Gene	controls|amod|START_ENTITY helper|nsubj|controls helper|dobj|development development|nmod|regulation regulation|nmod|END_ENTITY	Transforming_growth_factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma .
9420430	0	Transforming_growth_factor-beta	0,31	interferon-gamma	41,57	Transforming growth factor-beta	interferon-gamma	7040	3458	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Transforming_growth_factor-beta inhibits interferon-gamma secretion by lymphokine-activated killer cells stimulated with tumor cells .
9773986	0	Transforming_growth_factor-beta	0,31	interferon_alpha-2b	98,117	Transforming growth factor-beta	interferon alpha-2b	7040	3440	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Transforming_growth_factor-beta in thermally injured patients with hypertrophic_scars : effects of interferon_alpha-2b .
11282558	0	Transforming_growth_factor-beta	0,31	interleukin-10	41,55	Transforming growth factor-beta	interleukin-10	7040	3586	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|amod|END_ENTITY	Transforming_growth_factor-beta inhibits interleukin-10 synthesis by human monocytic cells .
16489941	0	Transforming_growth_factor-beta	0,31	interleukin-11	43,57	Transforming growth factor-beta	interleukin-11	7040	3589	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Transforming_growth_factor-beta stimulates interleukin-11 production by human periodontal ligament and gingival fibroblasts .
21898503	0	Transforming_growth_factor-beta	0,31	p53	83,86	Transforming growth factor-beta	p53	7040	22059(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY promotes|nsubj|signaling promotes|dobj|hepatocarcinogenesis hepatocarcinogenesis|acl|induced induced|nmod|loss loss|compound|END_ENTITY	Transforming_growth_factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss .
9735409	0	Transforming_growth_factor-beta	0,31	p53	85,88	Transforming growth factor-beta	p53	7040	7157	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Transforming_growth_factor-beta enhances the ultraviolet-mediated stress response in p53 - / - keratinocytes .
16288034	0	Transforming_growth_factor-beta	0,31	phosphatidylinositol_3-kinase	46,75	Transforming growth factor-beta	phosphatidylinositol 3-kinase	7040	5293	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Transforming_growth_factor-beta activation of phosphatidylinositol_3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated_kinase-2 .
15870504	0	Transforming_growth_factor-beta	0,31	plasmin	48,55	Transforming growth factor-beta	plasmin	7040	5340	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Transforming_growth_factor-beta is activated by plasmin and inhibits smooth muscle cell death in human saphenous vein .
7775119	0	Transforming_growth_factor-beta	0,31	plasminogen_activator_inhibitor_type-1	40,78	Transforming growth factor-beta	plasminogen activator inhibitor type-1	7040	5054	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Transforming_growth_factor-beta induces plasminogen_activator_inhibitor_type-1 in cultured human orbital fibroblasts .
1536863	0	Transforming_growth_factor-beta	0,31	surfactant_protein_A	41,61	Transforming growth factor-beta	surfactant protein A	7040	653509	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta inhibits surfactant_protein_A expression in vitro .
12161428	0	Transforming_growth_factor-beta	0,31	surfactant_protein_B	51,71	Transforming growth factor-beta	surfactant protein B	7040	6439	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	Transforming_growth_factor-beta inhibits pulmonary surfactant_protein_B gene transcription through SMAD3 interactions with NKX2 .1 and HNF-3 transcription factors .
14566975	0	Transforming_growth_factor-beta	0,31	vascular_endothelial_growth_factor	54,88	Transforming growth factor-beta	vascular endothelial growth factor	7040	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transforming_growth_factor-beta induces expression of vascular_endothelial_growth_factor in human retinal pigment epithelial cells : involvement of mitogen-activated protein kinases .
19582787	0	Transforming_growth_factor-beta1	0,32	ATF-3	47,52	Transforming growth factor-beta1	ATF-3	7040	467	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Transforming_growth_factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast_cancer cells .
19582787	0	Transforming_growth_factor-beta1	0,32	ATF-3	75,80	Transforming growth factor-beta1	ATF-3	7040	467	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|genes genes|compound|END_ENTITY	Transforming_growth_factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast_cancer cells .
20802130	0	Transforming_growth_factor-beta1	0,32	C-type_natriuretic_peptide	47,73	Transforming growth factor-beta1	C-type natriuretic peptide	7040	4880	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1 regulation of C-type_natriuretic_peptide expression in human vascular smooth_muscle_cells : dependence on TSC22D1 .
11840268	0	Transforming_growth_factor-beta1	0,32	CD34	61,65	Transforming growth factor-beta1	CD34	7040	947	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Transforming_growth_factor-beta1 transcriptionally activates CD34 and prevents induced differentiation of TF-1 cells in the absence of any cell-cycle effects .
12139758	0	Transforming_growth_factor-beta1	0,32	CD34	70,74	Transforming growth factor-beta1	CD34	7040	947	Gene	Gene	causes|nsubj|START_ENTITY causes|dobj|activation activation|nmod|END_ENTITY	Transforming_growth_factor-beta1 causes transcriptional activation of CD34 and preserves haematopoietic stem/progenitor cell activity .
15373772	0	Transforming_growth_factor-beta1	0,32	CD34	99,103	Transforming growth factor-beta1	CD34	7040	947	Gene	Gene	regulates|nsubj|START_ENTITY regulates|ccomp|stem stem|nsubj|expression expression|nmod|receptor receptor|nmod|IgE IgE|nmod|END_ENTITY	Transforming_growth_factor-beta1 regulates the expression of the high-affinity receptor for IgE on CD34 stem cell-derived CD1a dendritic cells in vitro .
20154716	0	Transforming_growth_factor-beta1	0,32	CXC_chemokine_receptor_4	63,87	Transforming growth factor-beta1	CXC chemokine receptor 4	7040	7852	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta1 upregulates the expression of CXC_chemokine_receptor_4 -LRB- CXCR4 -RRB- in human breast_cancer MCF-7 cells .
11960552	0	Transforming_growth_factor-beta1	0,32	Hyal-2	111,117	Transforming growth factor-beta1	Hyal-2	21803(Tax:10090)	15587(Tax:10090)	Gene	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	Transforming_growth_factor-beta1 blocks the enhancement of tumor_necrosis_factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts .
15737692	0	Transforming_growth_factor-beta1	0,32	LMO7	41,45	Transforming growth factor-beta1	LMO7	59086(Tax:10116)	361084(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Transforming_growth_factor-beta1 induces LMO7 while enhancing the invasiveness of rat ascites hepatoma cells .
12853969	0	Transforming_growth_factor-beta1	0,32	Smad2	138,143	Transforming growth factor-beta1	Smad2	7040	4087	Gene	Gene	activates|nsubj|START_ENTITY activates|advcl|signaling signaling|nsubj|collaboration collaboration|nmod|END_ENTITY	Transforming_growth_factor-beta1 activates interleukin-6 expression in prostate_cancer cells through the synergistic collaboration of the Smad2 , p38-NF-kappaB , JNK , and Ras signaling pathways .
14754879	0	Transforming_growth_factor-beta1	0,32	Smad3	102,107	Transforming growth factor-beta1	Smad3	7040	4088	Gene	Gene	inhibition|amod|START_ENTITY mediated|nsubjpass|inhibition mediated|nmod|END_ENTITY	Transforming_growth_factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3 .
16086788	0	Transforming_growth_factor-beta1	0,32	Th1	34,37	Transforming growth factor-beta1	Th1	21803(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|appos|responses responses|amod|END_ENTITY	Transforming_growth_factor-beta1 , Th1 responses , and autoimmune_liver_disease .
9405238	0	Transforming_growth_factor-beta1	0,32	aryl_hydrocarbon_receptor	64,89	Transforming growth factor-beta1	aryl hydrocarbon receptor	7040	196	Gene	Gene	coregulates|nsubj|START_ENTITY coregulates|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta1 coregulates mRNA expression of aryl_hydrocarbon_receptor and cell-cycle-regulating genes in human cancer cell lines .
11746354	0	Transforming_growth_factor-beta1	0,32	brain-derived_neurotrophic_factor	56,89	Transforming growth factor-beta1	brain-derived neurotrophic factor	59086(Tax:10116)	24225(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta1 enhances expression of brain-derived_neurotrophic_factor and its receptor , TrkB , in neurons cultured from rat cerebral cortex .
9515031	0	Transforming_growth_factor-beta1	0,32	c-fos	83,88	Transforming growth factor-beta1	c-fos	59086(Tax:10116)	314322(Tax:10116)	Gene	Gene	synergistically|compound|START_ENTITY activate|nsubj|synergistically activate|dobj|element element|amod|END_ENTITY	Transforming_growth_factor-beta1 and protein kinase C synergistically activate the c-fos serum response element in myocardial cells .
18287089	0	Transforming_growth_factor-beta1	0,32	connective_tissue_growth_factor	55,86	Transforming growth factor-beta1	connective tissue growth factor	7040	1490	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1 -LRB- TGFbeta1 -RRB- stimulates connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- expression in human gingival fibroblasts through a RhoA-independent , Rac1/Cdc42-dependent mechanism : statins with forskolin block TGFbeta1-induced CCN2/CTGF expression .
10692471	0	Transforming_growth_factor-beta1	0,32	cyclooxygenase-2	71,87	Transforming growth factor-beta1	cyclooxygenase-2	7040	5743	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA .
11061980	0	Transforming_growth_factor-beta1	0,32	endothelin-1	41,53	Transforming growth factor-beta1	endothelin-1	282089(Tax:9913)	281137(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Transforming_growth_factor-beta1 induces endothelin-1 in a bovine pulmonary artery endothelial cell line and rat lungs via cAMP .
17307160	0	Transforming_growth_factor-beta1	0,32	heme_oxygenase-1	44,60	Transforming growth factor-beta1	heme oxygenase-1	7040	3162	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1 stimulates heme_oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells .
10969803	0	Transforming_growth_factor-beta1	0,32	histone_deacetylase_1	42,63	Transforming growth factor-beta1	histone deacetylase 1	21803(Tax:10090)	433759(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Transforming_growth_factor-beta1 recruits histone_deacetylase_1 to a p130 repressor complex in transgenic_mice in vivo .
18507013	0	Transforming_growth_factor-beta1	0,32	insulin-like_growth_factor-I	102,130	Transforming growth factor-beta1	insulin-like growth factor-I	7040	3479	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Transforming_growth_factor-beta1 modulates tumor-stromal_cell_interactions_of_prostate_cancer through insulin-like_growth_factor-I .
10212284	0	Transforming_growth_factor-beta1	0,32	interleukin-6	41,54	Transforming growth factor-beta1	interleukin-6	7040	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1 induces interleukin-6 expression via activating_protein-1 consisting of JunD homodimers in primary human lung fibroblasts .
12853969	0	Transforming_growth_factor-beta1	0,32	interleukin-6	43,56	Transforming growth factor-beta1	interleukin-6	7040	3569	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1 activates interleukin-6 expression in prostate_cancer cells through the synergistic collaboration of the Smad2 , p38-NF-kappaB , JNK , and Ras signaling pathways .
16180102	0	Transforming_growth_factor-beta1	0,32	laminin_gamma1	47,61	Transforming growth factor-beta1	laminin gamma1	21803(Tax:10090)	226519(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta1 regulation of laminin_gamma1 and fibronectin expression and survival of mouse mesangial cells .
15854510	0	Transforming_growth_factor-beta1	1,33	matrix_metalloproteinase-9	45,71	Transforming growth factor-beta1	matrix metalloproteinase-9	21803(Tax:10090)	17395(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	-LSB- Transforming_growth_factor-beta1 stimulates matrix_metalloproteinase-9 production through ERK activation pathway and upregulation of Ets-1 protein -RSB- .
16077203	0	Transforming_growth_factor-beta1	0,32	myostatin	45,54	Transforming growth factor-beta1	myostatin	21803(Tax:10090)	17700(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta1 upregulates myostatin expression in mouse C2C12 myoblasts .
17305717	0	Transforming_growth_factor-beta1	0,32	nerve_growth_factor	64,83	Transforming growth factor-beta1	nerve growth factor	7040	4803	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta1 up-regulates the expression of nerve_growth_factor through mitogen-activated protein kinase signaling pathways in dental pulp cells .
11769973	0	Transforming_growth_factor-beta1	0,32	osteogenic_protein-1	118,138	Transforming growth factor-beta1	osteogenic protein-1	7040	655	Gene	Gene	supports|nsubj|START_ENTITY supports|dobj|morphogenesis morphogenesis|nmod|bone bone|acl|initiated initiated|nmod|END_ENTITY	Transforming_growth_factor-beta1 supports the rapid morphogenesis of heterotopic endochondral bone initiated by human osteogenic_protein-1 via the synergistic upregulation of molecular markers .
16677601	0	Transforming_growth_factor-beta1	0,32	peroxiredoxin-I	72,87	Transforming growth factor-beta1	peroxiredoxin-I	7040	5052	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Transforming_growth_factor-beta1 induces the non-classical secretion of peroxiredoxin-I in A549 cells .
10595400	0	Transforming_growth_factor-beta1	0,32	prolactin	46,55	Transforming growth factor-beta1	prolactin	59086(Tax:10116)	24683(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	Transforming_growth_factor-beta1 inhibits rat prolactin promoter activity in GH4 neuroendocrine cells .
9848725	0	Transforming_growth_factor-beta1	0,32	tumor_necrosis_factor-alpha	73,100	Transforming growth factor-beta1	tumor necrosis factor-alpha	7040	7124	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|resistance resistance|amod|END_ENTITY	Transforming_growth_factor-beta1 resistance in a thyroid_cancer model of tumor_necrosis_factor-alpha resistance .
10516092	0	Transforming_growth_factor-beta1	0,32	vascular_endothelial_growth_factor	61,95	Transforming growth factor-beta1	vascular endothelial growth factor	59086(Tax:10116)	83785(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta1 modulates the expression of vascular_endothelial_growth_factor by osteoblasts .
10971326	0	Transforming_growth_factor-beta1	0,32	vascular_endothelial_growth_factor	85,119	Transforming growth factor-beta1	vascular endothelial growth factor	7040	7422	Gene	Gene	increase|nsubj|START_ENTITY increase|dobj|production production|nmod|END_ENTITY	Transforming_growth_factor-beta1 and ultraviolet A1 radiation increase production of vascular_endothelial_growth_factor but not endothelin-1 in human dermal fibroblasts .
15143069	0	Transforming_growth_factor-beta1	0,32	vascular_endothelial_growth_factor	44,78	Transforming growth factor-beta1	vascular endothelial growth factor	21803(Tax:10090)	22339(Tax:10090)	Gene	Gene	164|amod|START_ENTITY 164|compound|END_ENTITY	Transforming_growth_factor-beta1 stimulates vascular_endothelial_growth_factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells .
18023419	0	Transforming_growth_factor-beta1	0,32	vascular_endothelial_growth_factor	42,76	Transforming growth factor-beta1	vascular endothelial growth factor	7040	7422	Gene	Gene	synthesis|amod|START_ENTITY synthesis|compound|END_ENTITY	Transforming_growth_factor-beta1 enhanced vascular_endothelial_growth_factor synthesis in mesenchymal stem cells .
11244304	0	Transforming_growth_factor-beta1	0,32	vascular_permeability_factor	42,70	Transforming growth factor-beta1	vascular permeability factor	7040	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Transforming_growth_factor-beta1 inhibits vascular_permeability_factor release by T cells in normal subjects and in patients with minimal-change nephrotic_syndrome .
15466377	0	Transforming_growth_factor-beta2	0,32	mucin	62,67	Transforming growth factor-beta2	mucin	7042	100508689	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta2 induces bronchial epithelial mucin expression in asthma .
17014662	0	Transforming_growth_factor-beta3	0,32	plasminogen_activator_inhibitor-1	41,74	Transforming growth factor-beta3	plasminogen activator inhibitor-1	21809(Tax:10090)	18787(Tax:10090)	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta3 affects plasminogen_activator_inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction .
1506415	0	Transforming_growth_factor-beta_1	0,33	Hsp70	50,55	Transforming growth factor-beta 1	Hsp70	100873157	423504(Tax:9031)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Transforming_growth_factor-beta_1 rapidly induces Hsp70 and Hsp90 molecular chaperones in cultured chicken embryo cells .
9864299	0	Transforming_growth_factor-beta_1	0,33	IL-2	55,59	Transforming growth factor-beta 1	IL-2	21803(Tax:10090)	16183(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- promotes IL-2 mRNA expression through the up-regulation of NF-kappaB , AP-1 and NF-AT in EL4 cells .
8683138	0	Transforming_growth_factor-beta_1	0,33	IL-8	61,65	Transforming growth factor-beta 1	IL-8	7040	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Transforming_growth_factor-beta_1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium .
9259183	0	Transforming_growth_factor-beta_1	0,33	Pax-2	62,67	Transforming growth factor-beta 1	Pax-2	100008645(Tax:9986)	100347596(Tax:9986)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor-beta_1 regulates the expression of Pax-2 , a developmental control gene , in renal tubule cells .
10973958	0	Transforming_growth_factor-beta_1	0,33	Smad3	86,91	Transforming growth factor-beta 1	Smad3	7040	4088	Gene	Gene	inhibition|amod|START_ENTITY mediated|nsubjpass|inhibition mediated|nmod|END_ENTITY	Transforming_growth_factor-beta_1 inhibition of macrophage activation is mediated via Smad3 .
14871177	0	Transforming_growth_factor-beta_1	0,33	TGF-beta_1	35,45	Transforming growth factor-beta 1	TGF-beta 1	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression in normal healthy pulps and in those with irreversible pulpitis .
1732279	0	Transforming_growth_factor-beta_1	0,33	TGF-beta_1	35,45	Transforming growth factor-beta 1	TGF-beta 1	59086(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression and regulation in rat cortical astrocytes .
8314838	0	Transforming_growth_factor-beta_1	0,33	alpha-smooth_muscle_actin	42,67	Transforming growth factor-beta 1	alpha-smooth muscle actin	59086(Tax:10116)	25365(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta_1 induces alpha-smooth_muscle_actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts .
14982932	0	Transforming_growth_factor-beta_1	0,33	collagenase-3	48,61	Transforming growth factor-beta 1	collagenase-3	59086(Tax:10116)	171052(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta_1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components , Smad2 and Runx2 .
7824270	0	Transforming_growth_factor-beta_1	0,33	cyclin_D1	43,52	Transforming growth factor-beta 1	cyclin D1	59086(Tax:10116)	58919(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta_1 inhibits cyclin_D1 expression in intestinal epithelial cells .
8085941	0	Transforming_growth_factor-beta_1	0,33	cytochrome_P450IA1	56,74	Transforming growth factor-beta 1	cytochrome P450IA1	7040	1543	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta_1 inhibits TCDD-induced cytochrome_P450IA1 expression in human lung_cancer A549 cells .
2167651	0	Transforming_growth_factor-beta_1	0,33	elastin	60,67	Transforming growth factor-beta 1	elastin	59086(Tax:10116)	25043(Tax:10116)	Gene	Gene	localizes|nsubj|START_ENTITY localizes|nmod|END_ENTITY	Transforming_growth_factor-beta_1 specifically localizes in elastin during synovial_inflammation : an immunoelectron microscopic study .
8325937	0	Transforming_growth_factor-beta_1	0,33	enkephalinase	43,56	Transforming growth factor-beta 1	enkephalinase	7040	4311	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor-beta_1 inhibits enkephalinase -LRB- EC 3.4.24.11 -RRB- gene expression in human endometrial stromal cells and sex skin fibroblasts in culture .
9081125	0	Transforming_growth_factor-beta_1	0,33	lysyl_oxidase	44,57	Transforming growth factor-beta 1	lysyl oxidase	59086(Tax:10116)	24914(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Transforming_growth_factor-beta_1 increases lysyl_oxidase enzyme activity and mRNA in rat aortic smooth muscle cells .
9106266	0	Transforming_growth_factor-beta_1	0,33	prolactin	43,52	Transforming growth factor-beta 1	prolactin	59086(Tax:10116)	24683(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Transforming_growth_factor-beta_1 inhibits prolactin secretion and lactotropic cell proliferation in the pituitary of oestrogen-treated Fischer 344 rats .
1322277	0	Transforming_growth_factor-beta_1	0,33	renin	78,83	Transforming growth factor-beta 1	renin	282089(Tax:9913)	280909(Tax:9913)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits aldosterone and stimulates adrenal renin in cultured bovine zona glomerulosa cells .
18234959	0	Transforming_growth_factor-beta_1	0,33	snail	108,113	Transforming growth factor-beta 1	snail	7040	6615	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta_1 promotes matrix_metalloproteinase-9-mediated oral_cancer invasion through snail expression .
8358733	0	Transforming_growth_factor-beta_1	0,33	transforming_growth_factor-alpha	42,74	Transforming growth factor-beta 1	transforming growth factor-alpha	7040	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Transforming_growth_factor-beta_1 induces transforming_growth_factor-alpha promoter activity and transforming_growth_factor-alpha secretion in the human colon_adenocarcinoma cell line FET .
14610327	0	Transforming_growth_factor-beta_1	0,33	vascular_endothelial_growth_factor	42,76	Transforming growth factor-beta 1	vascular endothelial growth factor	21803(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor-beta_1 induces vascular_endothelial_growth_factor expression in murine proximal tubular epithelial cells .
19180561	0	Transforming_growth_factor-beta_1	0,33	vascular_endothelial_growth_factor	75,109	Transforming growth factor-beta 1	vascular endothelial growth factor	7040	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- induces angiogenesis through vascular_endothelial_growth_factor -LRB- VEGF -RRB- - mediated apoptosis .
15203191	0	Transforming_growth_factor_Beta1	0,32	tissue_inhibitor_of_metalloproteinases_3	46,86	Transforming growth factor Beta1	tissue inhibitor of metalloproteinases 3	7040	7078	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Transforming_growth_factor_Beta1 induction of tissue_inhibitor_of_metalloproteinases_3 in articular chondrocytes is mediated by reactive oxygen species .
3258745	0	Transforming_growth_factor_alpha	0,32	C-FOS	58,63	Transforming growth factor alpha	C-FOS	21802(Tax:10090)	14281(Tax:10090)	Gene	Gene	induction|nsubj|START_ENTITY induction|nmod|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- induction of C-FOS and C-MYC expression in C3H 10T1/2 cells .
24685520	0	Transforming_growth_factor_alpha	0,32	ICAM-1	69,75	Transforming growth factor alpha	ICAM-1	7124	3383	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Transforming_growth_factor_alpha promotes osteosarcoma_metastasis by ICAM-1 and PI3K/Akt signaling pathway .
10449674	0	Transforming_growth_factor_alpha	0,32	TGF-alpha	34,43	Transforming growth factor alpha	TGF-alpha	7124	7039	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- expression in dysplastic_oral_leukoplakia : modulation by 13-cis retinoic_acid .
8712733	0	Transforming_growth_factor_alpha	0,32	TGF-alpha	34,43	Transforming growth factor alpha	TGF-alpha	7124	7039	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- expression in biopsies of colorectal_carcinoma is a significant prognostic indicator .
8027772	0	Transforming_growth_factor_alpha	0,32	TGF_alpha	34,43	Transforming growth factor alpha	TGF alpha	21802(Tax:10090)	21802(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- expression in degenerating motoneurons of the murine mutant wobbler : a neuronal signal for astrogliosis ?
16585207	0	Transforming_growth_factor_alpha	0,32	epidermal_growth_factor_receptor	64,96	Transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	drives|compound|START_ENTITY constitutive|nsubj|drives constitutive|dobj|activation activation|amod|END_ENTITY	Transforming_growth_factor_alpha expression drives constitutive epidermal_growth_factor_receptor pathway activation and sensitivity to gefitinib -LRB- Iressa -RRB- in human pancreatic_cancer cell lines .
8605103	0	Transforming_growth_factor_alpha	0,32	epidermal_growth_factor_receptor	112,144	Transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Transforming_growth_factor_alpha and epidermal_growth_factor levels in bladder_cancer and their relationship to epidermal_growth_factor_receptor .
7512173	0	Transforming_growth_factor_alpha	0,32	granulocyte-macrophage_colony-stimulating_factor	106,154	Transforming growth factor alpha	granulocyte-macrophage colony-stimulating factor	7124	1437	Gene	Gene	expression|compound|START_ENTITY expression|dep|regulation regulation|nmod|END_ENTITY	Transforming_growth_factor_alpha expression in normal human blood eosinophils : differential regulation by granulocyte-macrophage_colony-stimulating_factor and interleukin-3 .
9736044	0	Transforming_growth_factor_alpha	0,32	hepatocyte_growth_factor	81,105	Transforming growth factor alpha	hepatocyte growth factor	24827(Tax:10116)	24446(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	Transforming_growth_factor_alpha levels in liver and blood correlate better than hepatocyte_growth_factor with hepatocyte proliferation during liver_regeneration .
8380671	0	Transforming_growth_factor_alpha	0,32	myxoma_growth_factor	102,122	Transforming growth factor alpha	myxoma growth factor	100009150(Tax:9986)	932144(Tax:10273)	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	Transforming_growth_factor_alpha , Shope fibroma growth factor , and vaccinia growth factor can replace myxoma_growth_factor in the induction of myxomatosis in rabbits .
21618206	0	Transforming_growth_factor_b	0,28	CCN3	38,42	Transforming growth factor b	CCN3	21803(Tax:10090)	18133(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|nummod|END_ENTITY	Transforming_growth_factor_b controls CCN3 expression in nucleus pulposus cells of the intervertebral disc .
21104643	0	Transforming_growth_factor_b	0,28	TGF-b	30,35	Transforming growth factor b	TGF-b	7040	7040	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Transforming_growth_factor_b -LRB- TGF-b -RRB- levels in otherwise healthy subjects with impaired_glucose_tolerance .
25175023	0	Transforming_growth_factor_b	0,28	b-catenin	39,48	Transforming growth factor b	b-catenin	7040	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_b regulates b-catenin expression in lung fibroblast through NF-kB dependent pathway .
23727026	0	Transforming_growth_factor_b	0,28	connective_tissue_growth_factor	51,82	Transforming growth factor b	connective tissue growth factor	7040	1490	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor_b induces expression of connective_tissue_growth_factor in hepatic progenitor cells through Smad independent signaling .
26002466	0	Transforming_growth_factor_b-activated_kinase_1	0,47	stromal-derived_factor-1	92,116	Transforming growth factor b-activated kinase 1	stromal-derived factor-1	313121(Tax:10116)	24772(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_b-activated_kinase_1 negatively regulates interleukin-1a-induced stromal-derived_factor-1 expression in vascular smooth muscle cells .
22621932	0	Transforming_growth_factor_b1	0,29	p14	85,88	Transforming growth factor b1	p14	7040	11102	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	Transforming_growth_factor_b1 -LRB- TGF-b1 -RRB- suppresses growth of B-cell_lymphoma cells by p14 -LRB- ARF -RRB- - dependent regulation of mutant p53 .
23958169	0	Transforming_growth_factor_b1	1,30	stromal_cell_derived_factor_1	47,76	Transforming growth factor b1	stromal cell derived factor 1	7040	6387	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	-LSB- Transforming_growth_factor_b1 cooperates with stromal_cell_derived_factor_1 to affect the proliferation of hepatic oval cells via b-catenin inactivation -RSB- .
7852844	0	Transforming_growth_factor_beta	0,31	C3_and_factor_B_biosynthesis_and_complement_receptor_3	42,96	Transforming growth factor beta	C3 and factor B biosynthesis and complement receptor 3	7040	718	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta modulates C3_and_factor_B_biosynthesis_and_complement_receptor_3 expression in cultured human monocytes .
11672591	0	Transforming_growth_factor_beta	0,31	CD154	59,64	Transforming growth factor beta	CD154	7040	959	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor_beta enhances the expression of CD154 -LRB- CD40L -RRB- and production of tumor_necrosis_factor_alpha by human T lymphocytes .
2265243	0	Transforming_growth_factor_beta	0,31	IL-1	61,65	Transforming growth factor beta	IL-1	7040	3552	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Transforming_growth_factor_beta downregulates interleukin-1 -LRB- IL-1 -RRB- - induced IL-6 production by human monocytes .
12566226	0	Transforming_growth_factor_beta	0,31	Rac1	42,46	Transforming growth factor beta	Rac1	7040	5879	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Transforming_growth_factor_beta activates Rac1 and Cdc42Hs GTPases and the JNK pathway in skeletal muscle cells .
9788633	0	Transforming_growth_factor_beta	0,31	Smad1	50,55	Transforming growth factor beta	Smad1	7040	4086	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Transforming_growth_factor_beta signaling through Smad1 in human breast_cancer cells .
12034739	0	Transforming_growth_factor_beta	0,31	Smad2	42,47	Transforming growth factor beta	Smad2	7040	4087	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Transforming_growth_factor_beta activates Smad2 in the absence of receptor endocytosis .
14729983	0	Transforming_growth_factor_beta	0,31	Smad3	32,37	Transforming growth factor beta	Smad3	7040	4088	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Transforming_growth_factor_beta / Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter .
7592908	0	Transforming_growth_factor_beta	0,31	Sp1	112,115	Transforming growth factor beta	Sp1	7040	6667	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|site site|amod|END_ENTITY	Transforming_growth_factor_beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site .
8634677	0	Transforming_growth_factor_beta	0,31	TGF_beta	33,41	Transforming growth factor beta	TGF beta	7040	7040	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Transforming_growth_factor_beta -LRB- TGF_beta -RRB- activity in urine of patients with glomerulonephritis .
15372625	0	Transforming_growth_factor_beta	0,31	biglycan	47,55	Transforming growth factor beta	biglycan	7040	633	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors .
16867995	0	Transforming_growth_factor_beta	0,31	c-Abl	46,51	Transforming growth factor beta	c-Abl	7040	25	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Transforming_growth_factor_beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures .
10406964	0	Transforming_growth_factor_beta	0,31	clusterin	42,51	Transforming growth factor beta	clusterin	7040	1191	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor_beta regulates clusterin gene expression via modulation of transcription factor c-Fos .
1504015	0	Transforming_growth_factor_beta	0,31	epidermal_growth_factor_receptor	65,97	Transforming growth factor beta	epidermal growth factor receptor	7040	1956	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Transforming_growth_factor_beta modulates phosphorylation of the epidermal_growth_factor_receptor and proliferation of A431 cells .
7556448	0	Transforming_growth_factor_beta	0,31	epidermal_growth_factor_receptor	46,78	Transforming growth factor beta	epidermal growth factor receptor	7040	1956	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Transforming_growth_factor_beta regulation of epidermal_growth_factor_receptor in ectocervical epithelial cells .
21812925	0	Transforming_growth_factor_beta	0,31	interferon_gamma	76,92	Transforming growth factor beta	interferon gamma	7040	3458	Gene	Gene	expression|compound|START_ENTITY inhibits|nsubj|expression inhibits|dobj|production production|compound|END_ENTITY	Transforming_growth_factor_beta expression by human vascular cells inhibits interferon_gamma production and arterial media injury by alloreactive memory T cells .
8423782	0	Transforming_growth_factor_beta	0,31	interleukin-2	88,101	Transforming growth factor beta	interleukin-2	7040	3558	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|activity activity|nmod|gene gene|compound|END_ENTITY	Transforming_growth_factor_beta and cyclosporin_A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site .
2104224	0	Transforming_growth_factor_beta	0,31	interleukin_6	58,71	Transforming growth factor beta	interleukin 6	7040	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Transforming_growth_factor_beta induces the production of interleukin_6 by human peripheral blood mononuclear cells .
7777546	0	Transforming_growth_factor_beta	0,31	p21	78,81	Transforming growth factor beta	p21	7040	1026	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Transforming_growth_factor_beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism .
7706248	0	Transforming_growth_factor_beta	0,31	p44mapk	46,53	Transforming growth factor beta	p44mapk	7040	5595	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Transforming_growth_factor_beta activation of p44mapk in proliferating cultures of epithelial cells .
11590145	0	Transforming_growth_factor_beta	0,31	parathyroid_hormone-related_protein	42,77	Transforming growth factor beta	parathyroid hormone-related protein	7040	5744	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta regulates parathyroid_hormone-related_protein expression in MDA-MB-231_breast_cancer cells through a novel Smad/Ets synergism .
8472867	0	Transforming_growth_factor_beta	0,31	parathyroid_hormone-related_protein	47,82	Transforming growth factor beta	parathyroid hormone-related protein	7040	5744	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Transforming_growth_factor_beta stimulation of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- : a paracrine regulator ?
15372625	0	Transforming_growth_factor_beta	0,31	sp1	99,102	Transforming growth factor beta	sp1	7040	6667	Gene	Gene	stimulation|compound|START_ENTITY mediated|nsubj|stimulation mediated|nmod|factors factors|amod|END_ENTITY	Transforming_growth_factor_beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors .
11162896	0	Transforming_growth_factor_beta	0,31	steroidogenic_acute_regulatory	41,71	Transforming growth factor beta	steroidogenic acute regulatory	7040	6770	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta inhibits steroidogenic_acute_regulatory -LRB- StAR -RRB- protein expression in human ovarian thecal cells .
16785237	0	Transforming_growth_factor_beta	0,31	telomerase_reverse_transcriptase	49,81	Transforming growth factor beta	telomerase reverse transcriptase	7040	7015	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
1654118	0	Transforming_growth_factor_beta	0,31	tissue_inhibitor_of_metalloproteinases	65,103	Transforming growth factor beta	tissue inhibitor of metalloproteinases	7040	7076	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Transforming_growth_factor_beta stimulates the production of the tissue_inhibitor_of_metalloproteinases -LRB- TIMP -RRB- by human synovial and skin fibroblasts .
1908092	0	Transforming_growth_factor_beta	0,31	urokinase-type_plasminogen_activator	43,79	Transforming growth factor beta	urokinase-type plasminogen activator	7040	5328	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Transforming_growth_factor_beta stimulates urokinase-type_plasminogen_activator and DNA synthesis , but not prostaglandin_E2 production , in human synovial fibroblasts .
9892606	0	Transforming_growth_factor_beta1	0,32	Fas_ligand	42,52	Transforming growth factor beta1	Fas ligand	7040	356	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor_beta1 inhibits Fas_ligand expression and subsequent activation-induced cell death in T cells via downregulation of c-Myc .
12581383	0	Transforming_growth_factor_beta1	0,32	TGFbeta1	34,42	Transforming growth factor beta1	TGFbeta1	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor_beta1 -LRB- TGFbeta1 -RRB- expression in head_and_neck_squamous_cell_carcinoma patients as related to prognosis .
18353785	0	Transforming_growth_factor_beta1	0,32	c-Src	122,127	Transforming growth factor beta1	c-Src	7040	6714	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Transforming_growth_factor_beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin - , c-Src - , and p38 MAPK-dependent pathway .
9009143	0	Transforming_growth_factor_beta1	0,32	collagenase_3	42,55	Transforming growth factor beta1	collagenase 3	59086(Tax:10116)	171052(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta1 inhibits collagenase_3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures .
23891907	0	Transforming_growth_factor_beta_1	0,33	CXCL16	42,48	Transforming growth factor beta 1	CXCL16	7040	58191	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor_beta_1 induces CXCL16 and leukemia_inhibitory_factor expression in osteoclasts to modulate migration of osteoblast progenitors .
8344985	0	Transforming_growth_factor_beta_1	0,33	H-ras	109,114	Transforming growth factor beta 1	H-ras	21803(Tax:10090)	15461(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Transforming_growth_factor_beta_1 selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed fibrosarcoma cell lines .
12646700	0	Transforming_growth_factor_beta_1	0,33	NKp30	57,62	Transforming growth factor beta 1	NKp30	7040	259197	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transforming_growth_factor_beta_1 inhibits expression of NKp30 and NKG2D receptors : consequences for the NK-mediated killing of dendritic cells .
15144593	0	Transforming_growth_factor_beta_1	1,34	Smad2	92,97	Transforming growth factor beta 1	Smad2	21803(Tax:10090)	17126(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	-LSB- Transforming_growth_factor_beta_1 modulates connective_tissue_growth_factor expression via Smad2 signaling pathway in podocyte in vitro -RSB- .
21541485	0	Transforming_growth_factor_beta_1	0,33	TGF-beta_1	35,45	Transforming growth factor beta 1	TGF-beta 1	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- expression in proliferating thyroid_disease .
19136278	0	Transforming_growth_factor_beta_1	0,33	TGFbeta1	35,43	Transforming growth factor beta 1	TGFbeta1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGFbeta1 -RRB- gene polymorphisms and Chagas_disease susceptibility in Peruvian and Colombian patients .
1705121	0	Transforming_growth_factor_beta_1	0,33	alpha-fetoprotein	59,76	Transforming growth factor beta 1	alpha-fetoprotein	7040	174	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Transforming_growth_factor_beta_1 differentially regulates alpha-fetoprotein and albumin in HuH-7 human hepatoma cells .
1633111	0	Transforming_growth_factor_beta_1	0,33	c-myc	48,53	Transforming growth factor beta 1	c-myc	7040	4609	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta_1 regulation of c-myc expression , pRB phosphorylation , and cell cycle progression in keratinocytes .
9081122	0	Transforming_growth_factor_beta_1	0,33	insulin	71,78	Transforming growth factor beta 1	insulin	7040	3630	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Transforming_growth_factor_beta_1 inhibits the proliferative effect of insulin on human infragenicular vascular smooth muscle cells .
8528940	0	Transforming_growth_factor_beta_1	0,33	interleukin-10	43,57	Transforming growth factor beta 1	interleukin-10	7040	3586	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta_1 inhibits interleukin-10 mRNA expression and production in pokeweed mitogen-stimulated peripheral blood mononuclear cells and T cells .
11739168	0	Transforming_growth_factor_beta_1	0,33	p21	109,112	Transforming growth factor beta 1	p21	21803(Tax:10090)	12575(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|arrest arrest|nmod|cells cells|nmod|END_ENTITY	Transforming_growth_factor_beta_1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21 -LRB- Cip1/Waf1 -RRB- or p27 -LRB- Kip1 -RRB- .
16177030	0	Transforming_growth_factor_beta_1	0,33	p21	105,108	Transforming growth factor beta 1	p21	7040	1026	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Transforming_growth_factor_beta_1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex .
1565477	0	Transforming_growth_factor_beta_1	0,33	retinoblastoma	56,70	Transforming growth factor beta 1	retinoblastoma	7040	5925	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- inhibits retinoblastoma gene expression but not pRB phosphorylation in TGF-beta_1-growth stimulated colon_carcinoma cells .
1986928	0	Transforming_growth_factor_beta_1	0,33	steroid_17_alpha-hydroxylase	61,89	Transforming growth factor beta 1	steroid 17 alpha-hydroxylase	282089(Tax:9913)	281739(Tax:9913)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta_1 is a negative regulator of steroid_17_alpha-hydroxylase expression in bovine adrenocortical cells .
8129795	0	Transforming_growth_factor_beta_1	0,33	tissue_inhibitor_of_metalloproteinases-1	44,84	Transforming growth factor beta 1	tissue inhibitor of metalloproteinases-1	7040	7076	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Transforming_growth_factor_beta_1 regulates tissue_inhibitor_of_metalloproteinases-1 expression in differentiated human articular chondrocytes .
1708236	0	Transforming_growth_factor_beta_2	0,33	interleukin_1_beta	43,61	Transforming growth factor beta 2	interleukin 1 beta	81809(Tax:10116)	24494(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Transforming_growth_factor_beta_2 inhibits interleukin_1_beta - and tumour necrosis factor alpha-induction of nitric_oxide synthase in rat renal mesangial cells .
19049964	0	Transglutaminase-1	0,18	Stat-3	87,93	Transglutaminase-1	Stat-3	7051	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Transglutaminase-1 regulates renal epithelial cell proliferation through activation of Stat-3 .
24244820	0	Transglutaminase-2	110,128	Keratin_8	61,70	Transglutaminase-2	Keratin 8	7052	3856	Gene	Gene	Inhibition|compound|START_ENTITY Phosphorylation|nmod|Inhibition END_ENTITY|dobj|Phosphorylation	Ethacrynic_Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin_8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition .
24753817	0	Transglutaminase-2	108,126	Keratin_8	45,54	Transglutaminase-2	Keratin 8	7052	3856	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	12-O-Tetradecanoylphorbol-13-Acetate Induces Keratin_8 Phosphorylation and Reorganization via Expression of Transglutaminase-2 .
17337909	0	Transglutaminase_1	0,18	beta-actin	30,40	Transglutaminase 1	beta-actin	21816(Tax:10090)	11461(Tax:10090)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Transglutaminase_1 stabilizes beta-actin in endothelial cells correlating with a stabilization of intercellular junctions .
25449226	0	Transglutaminase_2	0,18	syndecan-4	34,44	Transglutaminase 2	syndecan-4	7052	6385	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transglutaminase_2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells .
20004474	0	Transglutaminase_II	0,19	rac1	35,39	Transglutaminase II	rac1	56083(Tax:10116)	363875(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transglutaminase_II interacts with rac1 , regulates production of reactive oxygen species , expression of snail , secretion of Th2 cytokines and mediates in vitro and in vivo_allergic_inflammation .
26892397	0	Transient_Receptor_Potential_Cation_Channel_Vanilloid_1	15,70	TRPV1	72,77	Transient Receptor Potential Cation Channel Vanilloid 1	TRPV1	193034(Tax:10090)	193034(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Transient_Receptor_Potential_Cation_Channel_Vanilloid_1 -LRB- TRPV1 -RRB- in Myoblast Fusion .
26233549	0	Transient_Receptor_Potential_Vanilloid_4	43,83	Protease-Activated_Receptor-2	0,29	Transient Receptor Potential Vanilloid 4	Protease-Activated Receptor-2	63873(Tax:10090)	14063(Tax:10090)	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Protease-Activated_Receptor-2 Up-Regulates Transient_Receptor_Potential_Vanilloid_4 Function in Mouse Esophageal Keratinocyte .
18468780	0	Transient_receptor_potential_A1	0,31	TRPA1	33,38	Transient receptor potential A1	TRPA1	8989	8989	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Transient_receptor_potential_A1 -LRB- TRPA1 -RRB- activity in the human urethra -- evidence for a functional role for TRPA1 in the outflow region .
20884333	0	Transient_receptor_potential_V1	0,31	transient_receptor_potential_A1	71,102	Transient receptor potential V1	transient receptor potential A1	100771135	100751384	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Transient_receptor_potential_V1 regulates activation and modulation of transient_receptor_potential_A1 by Ca2 + .
26746673	0	Transient_receptor_potential_ankyrin_1	0,38	TRPA1	40,45	Transient receptor potential ankyrin 1	TRPA1	277328(Tax:10090)	277328(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- receptor is involved in chronic arthritis : in vivo study using TRPA1-deficient mice .
25971967	0	Transient_receptor_potential_canonical_1	0,40	TRPC1	42,47	Transient receptor potential canonical 1	TRPC1	7220	7220	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transient_receptor_potential_canonical_1 -LRB- TRPC1 -RRB- channels as regulators of sphingolipid - and VEGF receptor expression : implications for thyroid_cancer cell migration and proliferation .
17508023	0	Transient_receptor_potential_vanilloid-1	0,40	matrix_metalloproteinase-1	69,95	Transient receptor potential vanilloid-1	matrix metalloproteinase-1	7442	4312	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|expression expression|amod|END_ENTITY	Transient_receptor_potential_vanilloid-1 mediates heat-shock-induced matrix_metalloproteinase-1 expression in human epidermal keratinocytes .
17977643	0	Transient_receptor_potential_vanilloid_type_2	0,45	TRPV2	47,52	Transient receptor potential vanilloid type 2	TRPV2	51393	51393	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transient_receptor_potential_vanilloid_type_2 -LRB- TRPV2 -RRB- expression in normal urothelium and in urothelial_carcinoma of human bladder : correlation with the pathologic stage .
17342325	0	Transketolase	0,13	TKTL1	22,27	Transketolase	TKTL1	7086	8277	Gene	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	Transketolase protein TKTL1 overexpression : A potential biomarker and therapeutic target in breast_cancer .
22912717	0	Translationally_Controlled_Tumour_Protein	11,52	HDM2	81,85	Translationally Controlled Tumour Protein	HDM2	7178	4193	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Binding of Translationally_Controlled_Tumour_Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3 .
22281008	0	Translationally_controlled_tumor_protein	0,40	Oct4	62,66	Translationally controlled tumor protein	Oct4	22070(Tax:10090)	100846986	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Translationally_controlled_tumor_protein -LRB- TCTP -RRB- downregulates Oct4 expression in mouse pluripotent cells .
21278788	0	Translationally_controlled_tumor_protein	0,40	Src	119,122	Translationally controlled tumor protein	Src	7178	6714	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Translationally_controlled_tumor_protein induces human breast epithelial cell transformation through the activation of Src .
14711818	0	Translin-associated_factor_X	0,28	TB-RBP	88,94	Translin-associated factor X	TB-RBP	53424(Tax:10090)	22099(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Translin-associated_factor_X is post-transcriptionally regulated by its partner protein TB-RBP , and both are essential for normal cell proliferation .
24692541	0	Translocator_Protein_of_18_kDa	140,170	TSPO	172,176	Translocator Protein of 18 kDa	TSPO	12257(Tax:10090)	12257(Tax:10090)	Gene	Gene	receptor|dep|START_ENTITY receptor|appos|END_ENTITY	Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor -LRB- Translocator_Protein_of_18_kDa -LRB- TSPO -RRB- -RRB- .
7492314	0	Translocon-associated_protein_TRAP_delta	0,40	pro-opiomelanocortin	103,123	Translocon-associated protein TRAP delta	pro-opiomelanocortin	397945(Tax:8355)	380532(Tax:8355)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Translocon-associated_protein_TRAP_delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary .
21306487	0	Translokin	0,10	cyclin_D1	34,43	Translokin	cyclin D1	9702	595	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Translokin -LRB- Cep57 -RRB- interacts with cyclin_D1 and prevents its nuclear accumulation in quiescent fibroblasts .
23661706	0	Transmembrane_Protein_214	0,25	caspase_4	82,91	Transmembrane Protein 214	caspase 4	54867	837	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Transmembrane_Protein_214 -LRB- TMEM214 -RRB- mediates endoplasmic reticulum stress-induced caspase_4 enzyme activation and apoptosis .
10918051	0	Transmembrane_phosphoprotein_Cbp	0,32	carboxyl-terminal_Src_kinase	74,102	Transmembrane phosphoprotein Cbp	carboxyl-terminal Src kinase	55824	1445	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Transmembrane_phosphoprotein_Cbp positively regulates the activity of the carboxyl-terminal_Src_kinase , Csk .
21646354	0	Transportin_2	0,13	HuR	66,69	Transportin 2	HuR	30000	1994	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Transportin_2 regulates apoptosis through the RNA-binding protein HuR .
19751836	0	Transthyretin	0,13	TTR	20,23	Transthyretin	TTR	7276	7276	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transthyretin gene -LRB- TTR -RRB- intron 1 elucidates crocodylian phylogenetic relationships .
18237193	0	Transthyretin	0,13	metallothionein_2	29,46	Transthyretin	metallothionein 2	7276	4502	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Transthyretin interacts with metallothionein_2 .
11278549	0	Trax	0,4	TB-RBP	94,100	Trax	TB-RBP	7257	7247	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|the the|nmod|END_ENTITY	Trax -LRB- translin-associated_factor_X -RRB- , a primarily cytoplasmic protein , inhibits the binding of TB-RBP -LRB- translin -RRB- to RNA .
18593568	0	Trb2	0,4	tribbles	25,33	Trb2	tribbles	217410(Tax:10090)	43999(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Trb2 , a mouse homolog of tribbles , is dispensable for kidney and mouse development .
20406475	0	Trc	42,45	Fry	15,18	Trc	Fry	40165(Tax:7227)	39122(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The Drosophila Fry protein interacts with Trc and is highly mobile in vivo .
22329990	0	Trefoil_factor_2	0,16	interleukin_33	33,47	Trefoil factor 2	interleukin 33	21785(Tax:10090)	77125(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Trefoil_factor_2 rapidly induces interleukin_33 to promote type 2 immunity during allergic_asthma and hookworm_infection .
23578537	0	Trefoil_factor_family_3	0,23	ER	86,88	Trefoil factor family 3	ER	7033	2099	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Trefoil_factor_family_3 -LRB- TFF3 -RRB- expression and its interaction with estrogen_receptor -LRB- ER -RRB- in endometrial_adenocarcinoma .
23578537	0	Trefoil_factor_family_3	0,23	TFF3	25,29	Trefoil factor family 3	TFF3	7033	7033	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Trefoil_factor_family_3 -LRB- TFF3 -RRB- expression and its interaction with estrogen_receptor -LRB- ER -RRB- in endometrial_adenocarcinoma .
11404018	0	Treh	62,66	trehalase	51,60	Treh	trehalase	58866(Tax:10090)	58866(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning , characterization and mapping of the mouse trehalase -LRB- Treh -RRB- gene .
20116089	0	Treslin	0,7	TopBP1	26,32	Treslin	TopBP1	90381	11073	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	Treslin collaborates with TopBP1 in triggering the initiation of DNA replication .
15611654	0	Trf1	36,40	Mad1	87,91	Trf1	Mad1	21749(Tax:10090)	17120(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The telomere repeat binding protein Trf1 interacts with the spindle checkpoint protein Mad1 and Nek2 mitotic kinase .
24082143	0	Trf2	22,26	Taf7l	0,5	Trf2	Taf7l	237336(Tax:10090)	74469(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Taf7l cooperates with Trf2 to regulate spermiogenesis .
25448845	0	Trh	29,32	TGFb2	0,5	Trh	TGFb2	22044(Tax:10090)	21808(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGFb2 regulates hypothalamic Trh expression through the TGFb_inducible_early_gene-1 -LRB- TIEG1 -RRB- during fetal development .
19340006	0	Triad1	21,27	UbcH7	58,63	Triad1	UbcH7	10425	7332	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains .
20226183	0	Triad_1	0,7	p53	29,32	Triad 1	p53	10425	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Triad_1 induces apoptosis by p53 activation .
15563848	0	Trib	87,91	testis-specific_ribbon_protein	55,85	Trib	testis-specific ribbon protein	67747(Tax:10090)	67747(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure and expression analysis of the mouse testis-specific_ribbon_protein -LRB- Trib -RRB- gene .
24161842	0	Trib1	28,33	ERK1/2	0,6	Trib1	ERK1/2	211770(Tax:10090)	26417;26413	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	ERK1/2 regulates hepatocyte Trib1 in response to mitochondrial_dysfunction .
17227832	0	Trib1	0,5	Hoxa	30,34	Trib1	Hoxa	211770(Tax:10090)	111336(Tax:10090)	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis .
17724128	0	Trib1	58,63	NF-IL6	22,28	Trib1	NF-IL6	211770(Tax:10090)	12608(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency .
23261831	0	Trib3	0,5	IL-3	22,26	Trib3	IL-3	228775(Tax:10090)	16187(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Trib3 is regulated by IL-3 and affects bone marrow-derived mast cell survival and function .
21076579	0	Tribbles-Related_Protein_3	14,40	Insulin	65,72	Tribbles-Related Protein 3	Insulin	57761	3630	Gene	Gene	START_ENTITY|nmod|Expression Expression|compound|END_ENTITY	The Effect of Tribbles-Related_Protein_3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells .
26657055	0	Tribbles_Pseudokinase_1	8,31	TRIB1	33,38	Tribbles Pseudokinase 1	TRIB1	10221	10221	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of Tribbles_Pseudokinase_1 -LRB- TRIB1 -RRB- in human hepatocyte metabolism .
21053424	0	Tribbles_homolog_1	6,24	retinoic_acid_receptor	62,84	Tribbles homolog 1	retinoic acid receptor	10221	5914	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Human Tribbles_homolog_1 functions as a negative regulator of retinoic_acid_receptor .
17097562	0	Tribbles_homolog_2	0,18	C/EBPalpha	31,41	Tribbles homolog 2	C/EBPalpha	28951	1050	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	Tribbles_homolog_2 inactivates C/EBPalpha and causes acute_myelogenous_leukemia .
26738569	0	Triggering_Receptor_Expressed_on_Myeloid_Cells_1	37,85	TGF-b1	0,6	Triggering Receptor Expressed on Myeloid Cells 1	TGF-b1	58217(Tax:10090)	21803(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Upregulates|dobj|Expression Upregulates|nsubj|END_ENTITY	TGF-b1 Upregulates the Expression of Triggering_Receptor_Expressed_on_Myeloid_Cells_1 in Murine Lungs .
26374899	0	Triggering_Receptor_Expressed_on_Myeloid_Cells_2	33,81	Apolipoprotein_E	0,16	Triggering Receptor Expressed on Myeloid Cells 2	Apolipoprotein E	54209	348	Gene	Gene	Ligand|nmod|START_ENTITY Ligand|nsubj|END_ENTITY	Apolipoprotein_E Is a Ligand for Triggering_Receptor_Expressed_on_Myeloid_Cells_2 -LRB- TREM2 -RRB- .
18321350	0	Triggering_receptor_expressed_on_myeloid_cells-1	0,48	TREM-1	50,56	Triggering receptor expressed on myeloid cells-1	TREM-1	54210	54210	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Triggering_receptor_expressed_on_myeloid_cells-1 -LRB- TREM-1 -RRB- expression on gastric epithelium : implication for a role of TREM-1 in Helicobacter_pylori_infection .
19136554	0	Trihydrophobin_1	0,16	PAK1	32,36	Trihydrophobin 1	PAK1	51497	5058	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	Trihydrophobin_1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration .
18026104	0	Trim24	8,14	Tif1alpha	16,25	Trim24	Tif1alpha	21848(Tax:10090)	21848(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Loss of Trim24 -LRB- Tif1alpha -RRB- gene function confers oncogenic activity to retinoic_acid_receptor_alpha .
25100564	0	Trim32	0,6	MYCN	34,38	Trim32	MYCN	22954	4613	Gene	Gene	Degradation|compound|START_ENTITY Degradation|nmod|END_ENTITY	Trim32 Facilitates Degradation of MYCN on Spindle Poles and Induces Asymmetric Cell Division in Human Neuroblastoma Cells .
23789107	0	Trio	12,16	Ets2	93,97	Trio	Ets2	7204	2114	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2 .
11146652	0	Trio	42,46	Rac1	4,8	Trio	Rac1	7204	5879	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The Rac1 - and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin .
18212043	0	Trio	0,4	Rac1	31,35	Trio	Rac1	223435(Tax:10090)	19353(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|amod|END_ENTITY	Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance .
25655724	0	Trio	34,38	Supervillin	0,11	Trio	Supervillin	7204	6840	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation .
23663701	0	Trip12	0,6	Sox6	51,55	Trip12	Sox6	9320	55553	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Trip12 , a HECT domain E3 ubiquitin ligase , targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells .
21048113	0	Tripartite-motif_protein_30	0,27	NLRP3	49,54	Tripartite-motif protein 30	NLRP3	20128(Tax:10090)	216799(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nummod|END_ENTITY	Tripartite-motif_protein_30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production .
22539786	0	Tripartite_motif-containing_protein_38	0,38	NAP1	140,144	Tripartite motif-containing protein 38	NAP1	10475	64343	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	Tripartite_motif-containing_protein_38 negatively regulates TLR3/4 - _ and_RIG-I-mediated_IFN-b production and antiviral response by targeting NAP1 .
26041847	0	Tripeptidyl_Peptidase_II	0,24	ERK1	67,71	Tripeptidyl Peptidase II	ERK1	7174	5594	Gene	Gene	Levels|compound|START_ENTITY Levels|nmod|END_ENTITY	Tripeptidyl_Peptidase_II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2 .
23583445	0	Tristetraprolin	0,15	AHRR	27,31	Tristetraprolin	AHRR	7538	57491	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Tristetraprolin suppresses AHRR expression through mRNA destabilization .
18250465	0	Tristetraprolin	0,15	CXCL1	26,31	Tristetraprolin	CXCL1	22695(Tax:10090)	14825(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Tristetraprolin regulates CXCL1 -LRB- KC -RRB- mRNA stability .
16702957	0	Tristetraprolin	0,15	Cyclin_D1	26,35	Tristetraprolin	Cyclin D1	7538	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Tristetraprolin regulates Cyclin_D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling .
19542371	0	Tristetraprolin	0,15	IL-10	89,94	Tristetraprolin	IL-10	22695(Tax:10090)	16153(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10 .
22138182	0	Tristetraprolin	0,15	IL-17	31,36	Tristetraprolin	IL-17	7538	3605	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	Tristetraprolin down-regulates IL-17 through mRNA destabilization .
24292977	0	Tristetraprolin	0,15	IL-23	31,36	Tristetraprolin	IL-23	22695(Tax:10090)	83430(Tax:10090)	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	Tristetraprolin down-regulates IL-23 expression in colon_cancer cells .
26644407	0	Tristetraprolin	32,47	LARP4	0,5	Tristetraprolin	LARP4	7538	113251	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	LARP4 is regulated by TNFa in a Tristetraprolin -LRB- TTP -RRB- - dependent manner .
26644407	0	Tristetraprolin	32,47	TNFa	22,26	Tristetraprolin	TNFa	7538	7124	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	LARP4 is regulated by TNFa in a Tristetraprolin -LRB- TTP -RRB- - dependent manner .
21875902	0	Tristetraprolin	33,48	TTP	50,53	Tristetraprolin	TTP	7538	7538	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A synonymous polymorphism of the Tristetraprolin -LRB- TTP -RRB- gene , an AU-rich mRNA-binding protein , affects translation efficiency and response to Herceptin treatment in breast_cancer patients .
19697322	0	Tristetraprolin	0,15	VEGF	40,44	Tristetraprolin	VEGF	7538	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon_cancer .
26370510	0	Tristetraprolin	0,15	eIF4E2	25,31	Tristetraprolin	eIF4E2	7538	9470	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Tristetraprolin recruits eIF4E2 to repress translation of ARE-containing mRNAs .
21457063	0	Tristetraprolin	0,15	interleukin-6	26,39	Tristetraprolin	interleukin-6	22695(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tristetraprolin regulates interleukin-6 expression through p38_MAPK-dependent affinity changes with mRNA 3 ' untranslated region .
21656745	0	Tristetraprolin	0,15	interleukin-6	26,39	Tristetraprolin	interleukin-6	7538	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Tristetraprolin regulates interleukin-6 , which is correlated with tumor progression in patients with head_and_neck_squamous_cell_carcinoma .
15366010	0	Trithorax	25,34	PP1beta9C	0,9	Trithorax	PP1beta9C	41737(Tax:7227)	44289(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PP1beta9C interacts with Trithorax in Drosophila wing development .
7900984	0	Trithorax	0,9	bithorax	51,59	Trithorax	bithorax	41737(Tax:7227)	42034(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific , parasegment-specific and promoter-specific effects on each .
16860569	0	Trk	18,21	Fyn	11,14	Trk	Fyn	4914	2534	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling .
8858917	0	Trk	67,70	Interleukin-6	0,13	Trk	Interleukin-6	59109(Tax:10116)	24498(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY induces|nmod|receptor induces|nsubj|END_ENTITY	Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signaling to promote neuronal differentiation in PC12 cells .
26546150	0	Trk	43,46	LINGO-1	14,21	Trk	LINGO-1	59109(Tax:10116)	315691(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY regulates|dobj|receptor regulates|nsubj|END_ENTITY	Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling .
9715270	0	Trk	56,59	Nerve_growth_factor	0,19	Trk	Nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	interaction|compound|START_ENTITY requires|dobj|interaction requires|nsubj|stimulation stimulation|compound|END_ENTITY	Nerve_growth_factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide_3-OH kinase .
16223723	0	Trk	61,64	SLAM-associated_protein	0,23	Trk	SLAM-associated protein	59109(Tax:10116)	29339(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	SLAM-associated_protein as a potential negative regulator in Trk signaling .
16611639	0	Trk	34,37	STAT3	0,5	Trk	STAT3	59109(Tax:10116)	25125(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	STAT3 as a downstream mediator of Trk signaling and functions .
10614630	0	Trk	35,38	nerve_growth_factor	15,34	Trk	nerve growth factor	4914	4803	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Suppression of nerve_growth_factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate_cancer cell proliferation .
15312164	0	Trk	58,61	nerve_growth_factor	24,43	Trk	nerve growth factor	4914	18049(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY regulation|nmod|receptors regulation|nmod|expression expression|compound|END_ENTITY	Autocrine regulation of nerve_growth_factor expression by Trk receptors .
7517456	0	Trk	71,74	nerve_growth_factor	30,49	Trk	nerve growth factor	18211(Tax:10090)	18049(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY involved|nmod|receptor involved|nsubj|determinants determinants|nmod|END_ENTITY	Immunological determinants of nerve_growth_factor involved in p140trk -LRB- Trk -RRB- receptor binding .
7902578	0	Trk	83,86	nerve_growth_factor	14,33	Trk	nerve growth factor	18211(Tax:10090)	18049(Tax:10090)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nsubj|Expression Expression|nmod|tyrosine tyrosine|compound|END_ENTITY	Expression of nerve_growth_factor and nerve_growth_factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones .
11399424	0	Trk	0,3	neurotrophin	28,40	Trk	neurotrophin	4914	627	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|mediators mediators|nmod|action action|compound|END_ENTITY	Trk receptors : mediators of neurotrophin action .
11738045	0	Trk	15,18	neurotrophin	28,40	Trk	neurotrophin	4914	627	Gene	Gene	receptor|compound|START_ENTITY interactions|nmod|receptor interactions|compound|END_ENTITY	Specificity in Trk receptor : neurotrophin interactions : the crystal structure of TrkB-d5 in complex with neurotrophin-4 / 5 .
16701206	0	Trk	22,25	neurotrophin	26,38	Trk	neurotrophin	4914	627	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination .
19759314	0	Trk	20,23	neurotrophin	76,88	Trk	neurotrophin	4914	627	Gene	Gene	receptors|compound|START_ENTITY Axonal|nmod|receptors regulates|nsubj|Axonal regulates|nmod|responses responses|compound|END_ENTITY	Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses .
20923662	0	Trk	102,105	neurotrophin	46,58	Trk	neurotrophin	4914	627	Gene	Gene	receptors|compound|START_ENTITY N-terminal|nmod|receptors N-terminal|nsubj|Role Role|nmod|versatility versatility|nmod|END_ENTITY	Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors .
8580709	0	Trk	44,47	neurotrophin	16,28	Trk	neurotrophin	4914	627	Gene	Gene	events|nmod|START_ENTITY events|nmod|signalling signalling|compound|END_ENTITY	Early events in neurotrophin signalling via Trk and p75 receptors .
8951673	0	Trk	27,30	neurotrophin	71,83	Trk	neurotrophin	4914	627	Gene	Gene	receptor|compound|START_ENTITY determinants|nmod|receptor specificities|nsubj|determinants specificities|xcomp|using using|dobj|chimeras chimeras|compound|END_ENTITY	Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras .
9488719	0	Trk	152,155	neurotrophin-3	89,103	Trk	neurotrophin-3	4914	4908	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors .
11074460	0	Trk	95,98	neurotrophin-4	75,89	Trk	neurotrophin-4	18211(Tax:10090)	78405(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Axonal outgrowth from adult mouse nodose ganglia in vitro is stimulated by neurotrophin-4 in a Trk receptor and mitogen-activated protein kinase-dependent way .
25350780	0	Trk	102,105	pan-Tropomyosin_Receptor_Kinases	68,100	Trk	pan-Tropomyosin Receptor Kinases	59109(Tax:10116)	59109(Tax:10116)	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	Syntheses and Evaluation of Carbon-11 - and Fluorine-18-Radiolabeled pan-Tropomyosin_Receptor_Kinases -LRB- Trk -RRB- Inhibitors : Exploration of the 4-aza-2-Oxindole Scaffold as Trk PET Imaging Agents .
23022575	0	Trk	41,44	tyrosine_kinase_receptor	15,39	Trk	tyrosine kinase receptor	4914	4914	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Alterations in tyrosine_kinase_receptor -LRB- Trk -RRB- expression induced by insulin-like_growth_factor-1 in cultured dorsal root ganglion neurons .
23769847	0	Trk	93,96	tyrosine_kinase_receptor	67,91	Trk	tyrosine kinase receptor	4914	4914	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Neuroprotective effect of insulin-like_growth_factor-1 : effects on tyrosine_kinase_receptor -LRB- Trk -RRB- expression in dorsal root ganglion neurons with glutamate-induced excitotoxicity in vitro .
19263582	0	Trk-A	99,104	nerve_growth_factor_receptor	69,97	Trk-A	nerve growth factor receptor	4914	4804	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of acetyl-l-carnitine on ovarian_cancer cells ' proliferation , nerve_growth_factor_receptor -LRB- Trk-A and p75 -RRB- expression , and the cytotoxic potential of paclitaxel and carboplatin .
17000777	0	TrkA	22,26	APPL1	0,5	TrkA	APPL1	59109(Tax:10116)	290537(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	APPL1 associates with TrkA and GIPC1 and is required for nerve_growth_factor-mediated signal transduction .
10329710	0	TrkA	42,46	Csk_homologous_kinase	4,25	TrkA	Csk homologous kinase	59109(Tax:10116)	29194(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	The Csk_homologous_kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells .
18378044	0	TrkA	37,41	Egr-1	0,5	TrkA	Egr-1	4914	1958	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Egr-1 and Hipk2 are required for the TrkA to p75 -LRB- NTR -RRB- switch that occurs downstream of IGF1-R .
14622124	0	TrkA	67,71	GSK3beta	46,54	TrkA	GSK3beta	59109(Tax:10116)	84027(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
20680486	0	TrkA	84,88	JNK	38,41	TrkA	JNK	4914	5599	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Control of TrkA-induced cell death by JNK activation and differential expression of TrkA upon DNA damage .
17617666	0	TrkA	29,33	Ku70	76,80	TrkA	Ku70	4914	2547	Gene	Gene	involves|nsubj|START_ENTITY involves|dobj|END_ENTITY	Nerve growth factor receptor TrkA signaling in breast_cancer cells involves Ku70 to prevent apoptosis .
11007890	0	TrkA	20,24	NGF	0,3	TrkA	NGF	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking .
14622124	0	TrkA	67,71	NGF	0,3	TrkA	NGF	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY GSK3beta|nmod|receptor activates|nmod|GSK3beta activates|nsubj|END_ENTITY	NGF activates the phosphorylation of MAP1B by GSK3beta through the TrkA receptor and not the p75 -LRB- NTR -RRB- _ receptor .
14663198	0	TrkA	52,56	NGF	81,84	TrkA	NGF	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY impairs|dobj|response impairs|nmod|nerve_growth_factor nerve_growth_factor|appos|END_ENTITY	Loss of cell adhesion impairs the early response of TrkA to nerve_growth_factor -LRB- NGF -RRB- .
15051797	0	TrkA	226,230	NGF	50,53	TrkA	NGF	4914	4803	Gene	Gene	presence|nmod|START_ENTITY suggests|nmod|presence -RSB-|acl:relcl|suggests -4,9|dep|-RSB- antagonist|parataxis|-4,9 antagonist|nsubj|activity activity|nmod|nerve_growth_factor nerve_growth_factor|appos|END_ENTITY	Differential activity of the nerve_growth_factor -LRB- NGF -RRB- antagonist PD90780 -LSB- 7 - -LRB- benzolylamino -RRB- -4,9 - dihydro-4-methyl-9-oxo-pyrazolo -LSB- 5,1-b -RSB- quinazoline-2-carboxylic acid -RSB- suggests altered NGF-p75NTR interactions in the presence of TrkA .
15955426	0	TrkA	0,4	NGF	5,8	TrkA	NGF	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	TrkA NGF receptor plays a role in the modulation of p75NTR expression .
16644033	0	TrkA	72,76	NGF	57,60	TrkA	NGF	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	nerve_growth_factor|dep|START_ENTITY nerve_growth_factor|appos|END_ENTITY	Glucose regulates expression of the nerve_growth_factor -LRB- NGF -RRB- receptors TrkA and p75NTR in rat islets and INS-1E beta-cells .
20708239	0	TrkA	66,70	NGF	34,37	TrkA	NGF	353111(Tax:9913)	281350(Tax:9913)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	Detection of nerve_growth_factor -LRB- NGF -RRB- and its specific receptor -LRB- TrkA -RRB- in ejaculated bovine sperm , and the effects of NGF on sperm function .
25644424	0	TrkA	103,107	NGF	66,69	TrkA	NGF	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	nerve_growth_factor|appos|START_ENTITY nerve_growth_factor|appos|END_ENTITY	The effect of mild stress stimulation on the nerve_growth_factor -LRB- NGF -RRB- and tyrosine_kinase_receptor_A -LRB- TrkA -RRB- immunoreactivity in the paraventricular nucleus -LRB- PVN -RRB- of the hypothalamus and hippocampus in aged vs. adult rats .
12133829	0	TrkA	36,40	Nerve_growth_factor	0,19	TrkA	Nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Nerve_growth_factor signals through TrkA , phosphatidylinositol 3-kinase , and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 cells .
17548467	0	TrkA	52,56	Nerve_growth_factor	0,19	TrkA	Nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	concentration|nmod|START_ENTITY stimulates|dobj|concentration stimulates|nsubj|END_ENTITY	Nerve_growth_factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein .
23912036	0	TrkA	37,41	Nerve_growth_factor	0,19	TrkA	Nerve growth factor	59109(Tax:10116)	4803	Gene	Gene	receptor|compound|START_ENTITY acts|nmod|receptor acts|nsubj|END_ENTITY	Nerve_growth_factor acts through the TrkA receptor to protect sensory neurons from the damaging effects of the HIV-1 viral protein , Vpr .
8987776	0	TrkA	87,91	Nerve_growth_factor	0,19	TrkA	Nerve growth factor	4914	4803	Gene	Gene	receptors|compound|START_ENTITY express|dobj|receptors apoptosis|acl:relcl|express induces|dobj|apoptosis induces|nsubj|END_ENTITY	Nerve_growth_factor induces apoptosis in human medulloblastoma cell lines that express TrkA receptors .
12011113	0	TrkA	55,59	Pincher	0,7	TrkA	Pincher	59109(Tax:10116)	192204(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Pincher , a pinocytic_chaperone for nerve_growth_factor / TrkA signaling endosomes .
10585422	0	TrkA	67,71	Src	74,77	TrkA	Src	59109(Tax:10116)	83805(Tax:10116)	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Adenosine_A -LRB- 2A -RRB- _ receptor mRNA regulation by nerve_growth_factor is TrkA - , Src - , and Ras-dependent via extracellular regulated kinase and stress-activated protein kinase/c-Jun NH -LRB- 2 -RRB- - terminal kinase .
14988025	0	TrkA	69,73	Src	22,25	TrkA	Src	4914	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY facilitates|dobj|phosphorylation facilitates|nsubj|END_ENTITY	Constitutively active Src facilitates NGF-induced phosphorylation of TrkA and causes enhancement of the MAPK signaling in SK-N-MC cells .
10842245	0	TrkA	87,91	interferon-gamma	109,125	TrkA	interferon-gamma	4914	3458	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	Neuronal differentiation in human neuroblastoma cells by nerve_growth_factor following TrkA up-regulation by interferon-gamma .
10200344	0	TrkA	98,102	nerve_growth_factor	68,87	TrkA	nerve growth factor	4914	4803	Gene	Gene	Detection|appos|START_ENTITY Detection|nmod|polymorphisms polymorphisms|nmod|receptor receptor|compound|END_ENTITY	Detection of DNA polymorphisms and point mutations of high-affinity nerve_growth_factor receptor -LRB- TrkA -RRB- in human neuroblastoma .
10585422	0	TrkA	67,71	nerve_growth_factor	44,63	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	-|compound|START_ENTITY -|nsubj|regulation regulation|nmod|END_ENTITY	Adenosine_A -LRB- 2A -RRB- _ receptor mRNA regulation by nerve_growth_factor is TrkA - , Src - , and Ras-dependent via extracellular regulated kinase and stress-activated protein kinase/c-Jun NH -LRB- 2 -RRB- - terminal kinase .
10713102	0	TrkA	0,4	nerve_growth_factor	45,64	TrkA	nerve growth factor	4914	4803	Gene	Gene	amino_acids|nsubj|START_ENTITY amino_acids|dobj|specificity specificity|nmod|END_ENTITY	TrkA amino_acids controlling specificity for nerve_growth_factor .
10842245	0	TrkA	87,91	nerve_growth_factor	57,76	TrkA	nerve growth factor	4914	4803	Gene	Gene	up-regulation|compound|START_ENTITY END_ENTITY|nmod|up-regulation	Neuronal differentiation in human neuroblastoma cells by nerve_growth_factor following TrkA up-regulation by interferon-gamma .
10955718	0	TrkA	63,67	nerve_growth_factor	124,143	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Changes|nmod|expression thymus|nsubj|Changes thymus|nmod|levels levels|compound|END_ENTITY	Changes in the expression of the nerve_growth_factor receptors TrkA and p75LNGR in the rat thymus with ageing and increased nerve_growth_factor plasma levels .
11245580	0	TrkA	48,52	nerve_growth_factor	53,72	TrkA	nerve growth factor	18211(Tax:10090)	18049(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	mKlf7 , a potential transcriptional regulator of TrkA nerve_growth_factor receptor expression in sensory and sympathetic neurons .
12011113	0	TrkA	55,59	nerve_growth_factor	35,54	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY Pincher|parataxis|signaling Pincher|nmod|END_ENTITY	Pincher , a pinocytic_chaperone for nerve_growth_factor / TrkA signaling endosomes .
14663198	0	TrkA	52,56	nerve_growth_factor	60,79	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY impairs|dobj|response impairs|nmod|END_ENTITY	Loss of cell adhesion impairs the early response of TrkA to nerve_growth_factor -LRB- NGF -RRB- .
15051797	0	TrkA	226,230	nerve_growth_factor	29,48	TrkA	nerve growth factor	4914	4803	Gene	Gene	presence|nmod|START_ENTITY suggests|nmod|presence -RSB-|acl:relcl|suggests -4,9|dep|-RSB- antagonist|parataxis|-4,9 antagonist|nsubj|activity activity|nmod|END_ENTITY	Differential activity of the nerve_growth_factor -LRB- NGF -RRB- antagonist PD90780 -LSB- 7 - -LRB- benzolylamino -RRB- -4,9 - dihydro-4-methyl-9-oxo-pyrazolo -LSB- 5,1-b -RSB- quinazoline-2-carboxylic acid -RSB- suggests altered NGF-p75NTR interactions in the presence of TrkA .
21394800	0	TrkA	175,179	nerve_growth_factor	112,131	TrkA	nerve growth factor	4914	4803	Gene	Gene	receptor|compound|START_ENTITY domain|nmod|receptor encompassing|dobj|domain +|xcomp|encompassing +|nmod|fragment fragment|nmod|END_ENTITY	The inorganic perspective of nerve_growth_factor : interactions of Cu2 + and Zn2 + with the N-terminus fragment of nerve_growth_factor encompassing the recognition domain of the TrkA receptor .
21394800	0	TrkA	175,179	nerve_growth_factor	29,48	TrkA	nerve growth factor	4914	4803	Gene	Gene	receptor|compound|START_ENTITY domain|nmod|receptor encompassing|dobj|domain +|xcomp|encompassing +|acl|+ interactions|nmod|+ perspective|dep|interactions perspective|nmod|END_ENTITY	The inorganic perspective of nerve_growth_factor : interactions of Cu2 + and Zn2 + with the N-terminus fragment of nerve_growth_factor encompassing the recognition domain of the TrkA receptor .
26738323	0	TrkA	54,58	nerve_growth_factor	25,44	TrkA	nerve growth factor	4914	4803	Gene	Gene	receptor|dobj|START_ENTITY receptor|nsubj|ratio ratio|nmod|END_ENTITY	-LSB- Expression ratio of the nerve_growth_factor receptor TrkA to p75NTR correlates with the clinical stage and pathological grade of prostate_cancer -RSB- .
7543930	0	TrkA	34,38	nerve_growth_factor	56,75	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|cells cells|nmod|END_ENTITY	Multiple levels for regulation of TrkA in PC12 cells by nerve_growth_factor .
7896793	0	TrkA	49,53	nerve_growth_factor	24,43	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Small peptide mimics of nerve_growth_factor bind TrkA receptors and affect biological responses .
8170995	0	TrkA	14,18	nerve_growth_factor	57,76	TrkA	nerve growth factor	4914	4803	Gene	Gene	Expression|nmod|START_ENTITY confers|nsubj|Expression confers|xcomp|END_ENTITY	Expression of TrkA confers neuron-like responsiveness to nerve_growth_factor on an immortalized hypothalamic cell line .
8987823	0	TrkA	25,29	nerve_growth_factor	45,64	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	Endocytosis|nmod|START_ENTITY Endocytosis|dep|evidence evidence|dep|induces induces|nsubj|END_ENTITY	Endocytosis of activated TrkA : evidence that nerve_growth_factor induces formation of signaling endosomes .
9083066	0	TrkA	105,109	nerve_growth_factor	43,62	TrkA	nerve growth factor	4914	4803	Gene	Gene	receptor|compound|START_ENTITY determine|dobj|receptor determine|nsubj|sites sites|nmod|surface surface|nmod|molecule molecule|compound|END_ENTITY	Two restricted sites on the surface of the nerve_growth_factor molecule independently determine specific TrkA receptor binding and activation .
9166727	0	TrkA	81,85	nerve_growth_factor	38,57	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	dimer|nmod|START_ENTITY END_ENTITY|nmod|dimer	Ganglioside GM1 enhances induction by nerve_growth_factor of a putative dimer of TrkA .
9219271	0	TrkA	79,83	nerve_growth_factor	39,58	TrkA	nerve growth factor	4914	4803	Gene	Gene	receptor|compound|START_ENTITY site|nmod|receptor site|compound|END_ENTITY	Immunoglobulin-like domains define the nerve_growth_factor binding site of the TrkA receptor .
9514198	0	TrkA	90,94	nerve_growth_factor	26,45	TrkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	depend|nmod|START_ENTITY depend|nsubj|Duration Duration|nmod|signaling signaling|compound|END_ENTITY	Duration and magnitude of nerve_growth_factor signaling depend on the ratio of p75LNTR to TrkA .
10708759	0	TrkA	52,56	nerve_growth_factor_receptor	22,50	TrkA	nerve growth factor receptor	4914	4804	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of nerve_growth_factor_receptor , TrkA , with non-receptor tyrosine kinase , c-Abl , through the activation loop .
24333329	0	TrkA	72,76	p75_NTR	64,71	TrkA	p75 NTR	4914	4804	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Type I interferons up-regulate the expression and signalling of p75_NTR / TrkA receptor complex in differentiated human SH-SY5Y neuroblastoma cells .
9292513	0	TrkA	25,29	receptor_tyrosine_kinase	30,54	TrkA	receptor tyrosine kinase	4914	5979	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of functional TrkA receptor_tyrosine_kinase in the HMC-1 human mast cell line and in human mast cells .
26945060	0	TrkA	0,4	semaphorin3A	25,37	TrkA	semaphorin3A	4914	10371	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	TrkA mediates retrograde semaphorin3A signaling through PlexinA4 to regulate dendritic branching .
24484474	0	TrkA	72,76	suppressor_of_cytokine_signaling-2	16,50	TrkA	suppressor of cytokine signaling-2	59109(Tax:10116)	84607(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	A novel role of suppressor_of_cytokine_signaling-2 in the regulation of TrkA neurotrophin receptor biology .
26286016	0	TrkA	44,48	tropomyosin_receptor_kinase_A	13,42	TrkA	Tropomyosin receptor kinase A	59109(Tax:10116)	59109(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Blocking the tropomyosin_receptor_kinase_A -LRB- TrkA -RRB- receptor inhibits pain behaviour in two rat models of osteoarthritis .
12412144	0	TrkA	50,54	tyrosine_kinase	33,48	TrkA	tyrosine kinase	59109(Tax:10116)	59109(Tax:10116)	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Cystitis-induced upregulation of tyrosine_kinase -LRB- TrkA , TrkB -RRB- receptor expression and phosphorylation in rat micturition pathways .
10679773	0	TrkB	0,4	BDNF	80,84	TrkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY independent|nsubj|expression independent|nmod|END_ENTITY	TrkB expression and early sensory neuron survival are independent of endogenous BDNF .
10711692	0	TrkB	53,57	BDNF	31,35	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|transport transport|nmod|END_ENTITY	Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma .
10899288	0	TrkB	10,14	BDNF	55,59	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|endocytosis endocytosis|nmod|END_ENTITY	Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4 / 5 by rat astrocytes and schwann cells in vitro .
11553298	0	TrkB	57,61	BDNF	0,4	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	neurons|compound|START_ENTITY mRNA|nmod|neurons expression|nmod|mRNA increases|dobj|expression increases|nsubj|END_ENTITY	BDNF increases the early expression of TRH mRNA in fetal TrkB + hypothalamic neurons in primary culture .
11855816	0	TrkB	31,35	BDNF	75,79	TrkB	BDNF	4915	627	Gene	Gene	receptor|compound|START_ENTITY domain|nmod|receptor defines|nsubj|domain defines|dobj|sites sites|nmod|END_ENTITY	A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4 .
12614342	0	TrkB	93,97	BDNF	0,4	TrkB	BDNF	4915	627	Gene	Gene	activation|nmod|START_ENTITY heightens|nmod|activation heightens|nsubj|END_ENTITY	BDNF heightens the sensitivity of motor neurons to excitotoxic insults through activation of TrkB .
15518646	0	TrkB	58,62	BDNF	22,26	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise .
16173113	0	TrkB	19,23	BDNF	64,68	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Cellular levels of TrkB and MAPK in the neuroprotective role of BDNF for embryonic rat cortical neurons against hypoxia in vitro .
17711418	0	TrkB	22,26	BDNF	56,60	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY induces|nsubj|stimulation induces|dobj|increases increases|nmod|expressions expressions|compound|END_ENTITY	Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms .
17883412	0	TrkB	6,10	BDNF	0,4	TrkB	BDNF	4915	627	Gene	Gene	interaction|compound|START_ENTITY regulates|nsubj|interaction END_ENTITY|parataxis|regulates	BDNF / TrkB interaction regulates migration of SVZ precursor cells via PI3-K and MAP-K signalling pathways .
19424097	0	TrkB	45,49	BDNF	21,25	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|dobj|receptor	Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture .
20407211	0	TrkB	38,42	BDNF	15,19	TrkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY activate|ccomp|signaling activate|nsubj|mimetics mimetics|compound|END_ENTITY	Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal_degeneration in rodents .
20428771	0	TrkB	14,18	BDNF	0,4	TrkB	BDNF	4915	627	Gene	Gene	activation|compound|START_ENTITY signal|nsubj|activation mediated|ccomp|signal mediated|nsubj|END_ENTITY	BDNF mediated TrkB activation is a survival signal for transitional_cell_carcinoma cells .
20635439	0	TrkB	118,122	BDNF	74,78	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	brain-derived_neurotrophic_factor|appos|START_ENTITY brain-derived_neurotrophic_factor|appos|END_ENTITY	Acute stress and chronic stress change brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and tyrosine kinase-coupled receptor -LRB- TrkB -RRB- expression in both young and aged rat hippocampus .
20843342	0	TrkB	139,143	BDNF	133,137	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Dietary supplementation of soy germ phytoestrogens or estradiol improves spatial memory performance and increases gene expression of BDNF , TrkB receptor and synaptic factors in ovariectomized rats .
21196945	0	TrkB	110,114	BDNF	86,90	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Effects of chronic forced swim stress on hippocampal brain-derived neutrophic factor -LRB- BDNF -RRB- and its receptor -LRB- TrkB -RRB- immunoreactive cells in juvenile and aged rats .
21281620	0	TrkB	45,49	BDNF	63,67	TrkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice .
21666748	0	TrkB	35,39	BDNF	106,110	TrkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY transactivate|dobj|receptors transactivate|nmod|brain brain|nmod|END_ENTITY	Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade .
21775604	0	TrkB	97,101	BDNF	61,65	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	bridging|dobj|START_ENTITY signaling|advcl|bridging END_ENTITY|acl|signaling	JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1 .
22374757	0	TrkB	0,4	BDNF	116,120	TrkB	BDNF	4915	627	Gene	Gene	receptor|amod|START_ENTITY tractus|nsubj|receptor tractus|ccomp|mediates mediates|xcomp|effects effects|nmod|END_ENTITY	TrkB receptor signaling in the nucleus tractus solitarius mediates the food intake-suppressive effects of hindbrain BDNF and leptin .
22396798	0	TrkB	22,26	BDNF	30,34	TrkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	START_ENTITY|nmod|drugs drugs|compound|END_ENTITY	The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development .
22560237	0	TrkB	21,25	BDNF	131,135	TrkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	antagonist|compound|START_ENTITY prevent|nsubj|antagonist prevent|nmod|END_ENTITY	Cyclotraxin-B , a new TrkB antagonist , and glial blockade by propentofylline , equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital_nerve_constriction in mice .
23086941	0	TrkB	66,70	BDNF	120,124	TrkB	BDNF	4915	627	Gene	Gene	tropomyosin-related_kinase_B|appos|START_ENTITY tropomyosin-related_kinase_B|appos|END_ENTITY	LIM_kinase_1 -LRB- LIMK1 -RRB- interacts with tropomyosin-related_kinase_B -LRB- TrkB -RRB- and Mediates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced axonal elongation .
23977241	0	TrkB	30,34	BDNF	71,75	TrkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	trafficking|nmod|START_ENTITY enhances|nsubj|trafficking enhances|nmod|END_ENTITY	SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF .
24867303	0	TrkB	46,50	BDNF	78,82	TrkB	BDNF	4915	627	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF .
24934279	0	TrkB	0,4	BDNF	43,47	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|mechanism mechanism|acl:relcl|accelerates accelerates|nsubj|END_ENTITY	TrkB is involved in the mechanism by which BDNF accelerates the glutamate-induced death of rat neuroblastoma B35 cells .
25012754	0	TrkB	22,26	BDNF	40,44	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	responsiveness|nmod|START_ENTITY END_ENTITY|nsubj|responsiveness	The responsiveness of TrkB to exogenous BDNF in frontal cortex during antibiotic treatment of Streptococcus_pneumoniae_meningitis .
25456007	0	TrkB	14,18	BDNF	0,4	TrkB	BDNF	4915	627	Gene	Gene	activation|compound|START_ENTITY contributes|nsubj|activation mediated|ccomp|contributes mediated|nsubj|END_ENTITY	BDNF mediated TrkB activation contributes to the EMT progression and the poor prognosis in human salivary_adenoid_cystic_carcinoma .
26200505	0	TrkB	20,24	BDNF	0,4	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	BDNF , via truncated TrkB receptor , modulates GlyT1 and GlyT2 in astrocytes .
26786147	0	TrkB	43,47	BDNF	35,39	TrkB	BDNF	4915	627	Gene	Gene	Brain-derived_neurotrophic_factor|dep|START_ENTITY Brain-derived_neurotrophic_factor|appos|END_ENTITY	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - TrkB signaling in inflammation-related_depression and potential therapeutic targets .
7961713	1	TrkB	149,153	BDNF	94,98	TrkB	BDNF	4915	627	Gene	Gene	receptors|compound|START_ENTITY domains|nmod|receptors heterodimer|nmod|domains heterodimer|nsubj|END_ENTITY	BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors .
8394722	0	TrkB	13,17	BDNF	71,75	TrkB	BDNF	4915	627	Gene	Gene	Induction|nmod|START_ENTITY mediates|nsubj|Induction mediates|dobj|responsiveness responsiveness|nmod|END_ENTITY	Induction of TrkB by retinoic_acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells .
8752592	0	TrkB	49,53	BDNF	0,4	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY responsiveness|appos|protein responsiveness|amod|END_ENTITY	BDNF down-regulates neurotrophin responsiveness , TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons .
8911685	0	TrkB	92,96	BDNF	62,66	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing Activation|nmod|cells Activation|nmod|END_ENTITY	Activation of Ras and protection from apoptotic cell death by BDNF in PC12 cells expressing TrkB .
9184109	0	TrkB	46,50	BDNF	11,15	TrkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY regulation|nmod|protein Effects|nmod|regulation Effects|nmod|infusion infusion|compound|END_ENTITY	Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain .
16778834	0	TrkB	73,77	Bim	18,21	TrkB	Bim	4915	10018	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Downregulation of Bim by brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death .
12074588	0	TrkB	92,96	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	4915	627	Gene	Gene	receptor|compound|START_ENTITY protein|nmod|receptor interaction|nmod|protein promotes|dobj|interaction promotes|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor .
12438277	0	TrkB	48,52	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	4915	627	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol_3 ' - kinase pathway .
12719654	0	TrkB	34,38	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	4915	627	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|appos|signaling	Brain-derived_neurotrophic_factor / TrkB signaling in memory processes .
15140649	0	TrkB	42,46	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY reduces|dobj|protein reduces|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats .
15581399	0	TrkB	48,52	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	4915	627	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB protects neurons from HIV-1 / gp120-induced cell death .
16618748	0	TrkB	48,52	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	4915	627	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
19686240	0	TrkB	46,50	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	facilitates|dobj|START_ENTITY facilitates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor facilitates TrkB down-regulation and neuronal_injury after status_epilepticus in the rat hippocampus .
23640807	0	TrkB	34,38	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|appos|regulates	Brain-derived_neurotrophic_factor / TrkB signaling regulates daily astroglial plasticity in the suprachiasmatic nucleus : electron-microscopic evidence in mouse .
25043764	0	TrkB	66,70	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY promotes|dobj|activation promotes|nsubj|zinc zinc|amod|END_ENTITY	Brain-derived_neurotrophic_factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo .
9303531	0	TrkB	58,62	Brain-derived_neurotrophic_factor	0,33	TrkB	Brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	localized|nsubj|START_ENTITY END_ENTITY|appos|localized	Brain-derived_neurotrophic_factor / neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebrate retina .
18253057	0	TrkB	33,37	Brain-derived_neurotropic_factor	0,32	TrkB	Brain-derived neurotropic factor	4915	627	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|appos|signaling	Brain-derived_neurotropic_factor / TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia .
24619096	0	TrkB	12,16	CCK	31,34	TrkB	CCK	4915	885	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity .
23064382	0	TrkB	0,4	Cdk5	24,28	TrkB	Cdk5	18212(Tax:10090)	12568(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory .
25052836	0	TrkB	0,4	ErbB4	20,25	TrkB	ErbB4	4915	2066	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis .
17374610	0	TrkB	73,77	Hypoxia-inducible_factor-1	0,26	TrkB	Hypoxia-inducible factor-1	4915	3091	Gene	Gene	gene|compound|START_ENTITY activator|nmod|gene activator|nsubj|END_ENTITY	Hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- is a transcriptional activator of the TrkB neurotrophin receptor gene .
20377621	0	TrkB	29,33	LINGO-1	0,7	TrkB	LINGO-1	4915	84894	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	LINGO-1 negatively regulates TrkB phosphorylation after ocular_hypertension .
20811452	0	TrkB	66,70	Neurotrophin	0,12	TrkB	Neurotrophin	4915	627	Gene	Gene	does|nsubj|START_ENTITY neuronal_death|advcl|does neuronal_death|nsubj|TrkA TrkA|compound|END_ENTITY	Neurotrophin receptors TrkA and TrkC cause neuronal_death whereas TrkB does not .
25538243	0	TrkB	27,31	Neurotrophin	0,12	TrkB	Neurotrophin	4915	627	Gene	Gene	Receptors|compound|START_ENTITY signaling|nmod|Receptors signaling|compound|END_ENTITY	Neurotrophin signaling via TrkB and TrkC Receptors promote the growth of Brain_Tumor Initiating Cells .
24327964	0	TrkB	12,16	RGS9-2	31,37	TrkB	RGS9-2	18212(Tax:10090)	19739(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Ablation of TrkB expression in RGS9-2 cells leads to hyperphagic obesity .
17584746	0	TrkB	67,71	Runx3	25,30	TrkB	Runx3	4915	864	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons .
20663410	0	TrkB	20,24	ShcD	0,4	TrkB	ShcD	4915	399694	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ShcD interacts with TrkB via its PTB and SH2 domains and regulates BDNF-induced MAPK activation .
22878065	0	TrkB	20,24	Shp-2	0,5	TrkB	Shp-2	4915	5781	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Shp-2 regulates the TrkB receptor activity in the retinal_ganglion cells under glaucomatous stress .
26004511	0	TrkB	32,36	Slitrk5	0,7	TrkB	Slitrk5	4915	26050	Gene	Gene	Receptor|compound|START_ENTITY Receptor|compound|END_ENTITY	Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling .
25382057	0	TrkB	28,32	Tyrosine_kinase_receptor_B	0,26	TrkB	Tyrosine kinase receptor B	4915	4915	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Tyrosine_kinase_receptor_B -LRB- TrkB -RRB- expression in colorectal_cancers highlights anoikis resistance as a survival mechanism of tumour budding cells .
26992697	0	TrkB	17,21	adenylyl_cyclase_1	61,79	TrkB	adenylyl cyclase 1	18212(Tax:10090)	432530(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl_cyclase_1 and 8 knockout mice in a model of fetal alcohol_spectrum_disorder .
18045880	0	TrkB	85,89	ameloblastin	45,57	TrkB	ameloblastin	18212(Tax:10090)	11698(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Neurotrophic_factor neurotrophin-4 regulates ameloblastin expression via full-length TrkB .
10446295	0	TrkB	0,4	brain-derived_neurotrophic_factor	94,127	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	mutant|compound|START_ENTITY acts|nsubj|mutant acts|nmod|receptor receptor|amod|END_ENTITY	TrkB mutant lacking the amino-terminal half of the extracellular portion acts as a functional brain-derived_neurotrophic_factor receptor .
10825163	0	TrkB	12,16	brain-derived_neurotrophic_factor	61,94	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	autophosphorylation|compound|START_ENTITY reduces|dobj|autophosphorylation reduces|nmod|/ /|compound|END_ENTITY	p75 reduces TrkB tyrosine autophosphorylation in response to brain-derived_neurotrophic_factor and neurotrophin_4 / 5 .
10833508	0	TrkB	0,4	brain-derived_neurotrophic_factor	19,52	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	TrkB activation by brain-derived_neurotrophic_factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel .
11516824	0	TrkB	53,57	brain-derived_neurotrophic_factor	19,52	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the brain-derived_neurotrophic_factor / TrkB pathway in neuroprotecive effect of cyclosporin_A in forebrain_ischemia .
12470870	0	TrkB	70,74	brain-derived_neurotrophic_factor	24,57	TrkB	brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY Involvement|dep|pathway Involvement|nmod|END_ENTITY	Involvement of a spinal brain-derived_neurotrophic_factor / full-length TrkB pathway in the development of nerve_injury-induced thermal_hyperalgesia in mice .
12691830	0	TrkB	93,97	brain-derived_neurotrophic_factor	45,78	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	path|compound|START_ENTITY activation|nmod|path activation|amod|END_ENTITY	Cisplatin-induced cytotoxicity is blocked by brain-derived_neurotrophic_factor activation of TrkB signal transduction path in neuroblastoma .
12921913	0	TrkB	81,85	brain-derived_neurotrophic_factor	29,62	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of brain-derived_neurotrophic_factor and its receptor , TrkB , in the hippocampal_formation_of_schizophrenic_brains .
15312792	0	TrkB	98,102	brain-derived_neurotrophic_factor	23,56	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	receptor|compound|START_ENTITY activation|nmod|receptor required|nmod|activation required|nsubjpass|exposure exposure|nmod|END_ENTITY	Continuous exposure to brain-derived_neurotrophic_factor is required for persistent activation of TrkB receptor , the ERK signaling pathway , and the induction of neuropeptide_Y production in cortical cultures .
15647480	0	TrkB	67,71	brain-derived_neurotrophic_factor	16,49	TrkB	brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship of brain-derived_neurotrophic_factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia .
15704182	0	TrkB	75,79	brain-derived_neurotrophic_factor	13,46	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|pro-BDNF pro-BDNF|amod|END_ENTITY	The secreted brain-derived_neurotrophic_factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC .
15781614	0	TrkB	99,103	brain-derived_neurotrophic_factor	65,98	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	rescue|compound|START_ENTITY identification|dep|rescue identification|nmod|mediator mediator|nmod|END_ENTITY	Genetic and pharmacologic identification of Akt as a mediator of brain-derived_neurotrophic_factor / TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death .
16778834	0	TrkB	73,77	brain-derived_neurotrophic_factor	25,58	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Downregulation of Bim by brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death .
17959796	0	TrkB	70,74	brain-derived_neurotrophic_factor	35,68	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|dep|channels channels|nmod|END_ENTITY	Regulation of Na -LRB- v -RRB- 1.2 channels by brain-derived_neurotrophic_factor , TrkB , and associated Fyn kinase .
18020981	0	TrkB	135,139	brain-derived_neurotrophic_factor	101,134	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy : lessons learned from the brain-derived_neurotrophic_factor / TrkB signal transduction pathway .
18436387	0	TrkB	136,140	brain-derived_neurotrophic_factor	72,105	TrkB	brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Caffeine prevents age-associated recognition memory decline and changes brain-derived_neurotrophic_factor and tirosine kinase receptor -LRB- TrkB -RRB- content in mice .
18843977	0	TrkB	55,59	brain-derived_neurotrophic_factor	10,43	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	-LSB- Study of brain-derived_neurotrophic_factor activating TrkB signaling cascades in the pathogenesis of multiple_myeloma -RSB- .
19726361	0	TrkB	120,124	brain-derived_neurotrophic_factor	69,102	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|YZ-50 YZ-50|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of Polygala tenuifolia Willd YZ-50 on the mRNA expression of brain-derived_neurotrophic_factor and its receptor TrkB in rats with chronic_stress_depression -RSB- .
21988201	0	TrkB	25,29	brain-derived_neurotrophic_factor	65,98	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	changes|nmod|START_ENTITY changes|acl|signaling signaling|nmod|END_ENTITY	Developmental changes of TrkB signaling in response to exogenous brain-derived_neurotrophic_factor in primary cortical neurons .
22442142	0	TrkB	125,129	brain-derived_neurotrophic_factor	47,80	TrkB	brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY elevates|dobj|levels elevates|nsubj|overexpression overexpression|nmod|END_ENTITY	Targeted taste cell-specific overexpression of brain-derived_neurotrophic_factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells , increases taste bud size , and promotes gustatory innervation .
22995443	0	TrkB	105,109	brain-derived_neurotrophic_factor	70,103	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived_neurotrophic_factor , TrkB levels in rat induced by corticosterone administration .
25210182	0	TrkB	49,53	brain-derived_neurotrophic_factor	15,48	TrkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	autocrine/paracrine|nsubj|START_ENTITY END_ENTITY|parataxis|autocrine/paracrine	HBZ stimulates brain-derived_neurotrophic_factor / TrkB autocrine/paracrine signaling to promote survival of human T-cell_leukemia_virus_type_1-Infected_T cells .
9538265	0	TrkB	130,134	brain-derived_neurotrophic_factor	44,77	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Comparison of survival-promoting effects of brain-derived_neurotrophic_factor and neurotrophin-3 on PC12h cells stably expressing TrkB receptor .
9628753	0	TrkB	74,78	brain-derived_neurotrophic_factor	14,47	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of brain-derived_neurotrophic_factor and its cognate receptor , TrkB , in the rat suprachiasmatic nucleus .
9677306	0	TrkB	161,165	brain-derived_neurotrophic_factor	49,82	TrkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY sites|nmod|receptor phospholipase|nmod|sites requires|dobj|phospholipase requires|nsubj|Stimulation Stimulation|nmod|expression expression|nmod|END_ENTITY	Stimulation of neuropeptide_Y gene expression by brain-derived_neurotrophic_factor requires both the phospholipase Cgamma and Shc binding sites on its receptor , TrkB .
16051641	0	TrkB	26,30	c-Met	47,52	TrkB	c-Met	4915	4233	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness .
10366607	0	TrkB	0,4	neurotrophin	28,40	TrkB	neurotrophin	4915	627	Gene	Gene	isoforms|amod|START_ENTITY isoforms|nmod|specificities specificities|compound|END_ENTITY	TrkB isoforms with distinct neurotrophin specificities are expressed in predominantly nonoverlapping populations of avian dorsal root ganglion neurons .
10798407	0	TrkB	133,137	neurotrophin	40,52	TrkB	neurotrophin	4915	627	Gene	Gene	removal|nmod|START_ENTITY retraction|nmod|removal Cortical_degeneration|dep|retraction Cortical_degeneration|nmod|absence absence|nmod|signaling signaling|compound|END_ENTITY	Cortical_degeneration in the absence of neurotrophin signaling : dendritic retraction and neuronal_loss after removal of the receptor TrkB .
15507485	0	TrkB	10,14	neurotrophin	82,94	TrkB	neurotrophin	4915	627	Gene	Gene	outgrowth|compound|START_ENTITY involves|nsubj|outgrowth involves|dobj|receptor receptor|compound|END_ENTITY	Truncated TrkB receptor-induced outgrowth of dendritic_filopodia involves the p75 neurotrophin receptor .
8396171	0	TrkB	26,30	neurotrophin	31,43	TrkB	neurotrophin	4915	627	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus .
22678720	0	TrkB	97,101	tyrosine_protein_kinase_B	70,95	TrkB	tyrosine protein kinase B	25054(Tax:10116)	25054(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Postnatal development of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and tyrosine_protein_kinase_B -LRB- TrkB -RRB- receptor immunoreactivity in multiple brain stem respiratory-related nuclei of the rat .
16618748	0	TrkB	48,52	vascular_endothelial_growth_factor	61,95	TrkB	vascular endothelial growth factor	4915	7422	Gene	Gene	activation|nmod|START_ENTITY induces|nsubj|activation induces|dobj|expression expression|compound|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
12210087	0	TrkC	19,23	NTRK3	25,30	TrkC	NTRK3	4916	4916	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression of TrkC -LRB- NTRK3 -RRB- in human soft tissue tumours .
21828999	0	TrkC	51,55	Neurotrophin-3	0,14	TrkC	Neurotrophin-3	4916	4908	Gene	Gene	mesenchymal|amod|START_ENTITY stem|nsubj|mesenchymal promote|ccomp|stem promote|nsubj|cells cells|amod|END_ENTITY	Neurotrophin-3 gene-modified Schwann cells promote TrkC gene-modified mesenchymal stem cells to differentiate into neuron-like cells in poly -LRB- lactic-acid-co-glycolic_acid -RRB- multiple-channel conduit .
23746279	0	TrkC	77,81	Neurotrophin-3	0,14	TrkC	Neurotrophin-3	4916	4908	Gene	Gene	overexpressing|dobj|START_ENTITY cells|acl|overexpressing migration|nmod|cells stimulates|dobj|migration stimulates|nsubj|END_ENTITY	Neurotrophin-3 stimulates migration of mesenchymal stem cells overexpressing TrkC .
8626576	0	TrkC	119,123	Neurotrophin-3	0,14	TrkC	Neurotrophin-3	29613(Tax:10116)	81737(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY action|nmod|receptor increases|nmod|action increases|nsubj|END_ENTITY	Neurotrophin-3 increases intracellular calcium in a rat insulin-secreting cell line through its action on a functional TrkC receptor .
14614136	0	TrkC	29,33	Neurotrophin_3	0,14	TrkC	Neurotrophin 3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Neurotrophin_3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway .
20078941	0	TrkC	21,25	ShcD	1,5	TrkC	ShcD	4916	399694	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	-LSB- ShcD interacts with TrkC through its PTB and SH2 domains -RSB- .
11519486	0	TrkC	70,74	neurotrophin-3	45,59	TrkC	neurotrophin-3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|receptor receptor|amod|END_ENTITY	Adenovirus vector-directed expression of the neurotrophin-3 receptor -LRB- TrkC -RRB- in mouse astrocytes .
17278135	0	TrkC	16,20	neurotrophin-3	53,67	TrkC	neurotrophin-3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|nmod|signaling signaling|amod|END_ENTITY	Localization of TrkC to Schwann cells and effects of neurotrophin-3 signaling at neuromuscular synapses .
9078261	0	TrkC	98,102	neurotrophin-3	121,135	TrkC	neurotrophin-3	29613(Tax:10116)	81737(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Analysis of mitogen-activated protein kinase activation by naturally occurring splice variants of TrkC , the receptor for neurotrophin-3 .
16142215	0	TrkC	65,69	neurotrophin_3	31,45	TrkC	neurotrophin 3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Genetic evidence for selective neurotrophin_3 signalling through TrkC but not TrkB in vivo .
20540510	0	TrkC	62,66	tropomysin_receptor_kinase_C	32,60	TrkC	tropomysin receptor kinase C	4916	4916	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Bivalent diketopiperazine-based tropomysin_receptor_kinase_C -LRB- TrkC -RRB- antagonists .
27022065	0	Trop-2	0,6	Akt	36,39	Trop-2	Akt	4070	207	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Trop-2 induces tumor growth through Akt and determines sensitivity to Akt inhibitors .
23597635	0	Tropoelastin	0,12	VEGF	52,56	Tropoelastin	VEGF	2006	7422	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Tropoelastin modulates TGF-b1-induced expression of VEGF and CTGF in airway smooth muscle cells .
26811602	0	Tropomyosin-related_kinase_B	0,28	brain_derived-neurotrophic_factor	29,62	Tropomyosin-related kinase B	brain derived-neurotrophic factor	4915	627	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Tropomyosin-related_kinase_B / brain_derived-neurotrophic_factor signaling pathway as a potential therapeutic target for colorectal_cancer .
23142137	0	Troy	0,4	lgr5	69,73	Troy	lgr5	29820(Tax:10090)	14160(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Troy , a tumor necrosis factor receptor family member , interacts with lgr5 to inhibit wnt signaling in intestinal stem cells .
16530883	0	Trp3	1,5	growth_hormone	37,51	Trp3	growth hormone	22065(Tax:10090)	14599(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	-LSB- Trp3 , Arg5 -RSB- - ghrelin -LRB- 1-5 -RRB- stimulates growth_hormone secretion and food intake via growth_hormone_secretagogue _ -LRB- GHS -RRB- _ receptor .
21402876	0	Trp53	0,5	Notch_4	16,23	Trp53	Notch 4	7157	4855	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Trp53 regulates Notch_4 signaling through Mdm2 .
17219434	0	Trp53	86,91	PP2Cdelta	0,9	Trp53	PP2Cdelta	22059(Tax:10090)	53892(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	PP2Cdelta -LRB- Ppm1d , WIP1 -RRB- , an endogenous inhibitor of p38_MAPK , is regulated along with Trp53 and Cdkn2a following p38_MAPK inhibition during mouse preimplantation development .
23657012	0	Trp53	22,27	Palb2	0,5	Trp53	Palb2	22059(Tax:10090)	233826(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Palb2 synergizes with Trp53 to suppress mammary_tumor formation in a model of inherited_breast_cancer .
10749125	0	Trp53	107,112	Xpc	95,98	Trp53	Xpc	22059(Tax:10090)	22591(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin_cancers in Xpc and Xpc Trp53 mutant mice .
17219434	0	Trp53	86,91	p38_MAPK	113,121	Trp53	p38 MAPK	22059(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	PP2Cdelta -LRB- Ppm1d , WIP1 -RRB- , an endogenous inhibitor of p38_MAPK , is regulated along with Trp53 and Cdkn2a following p38_MAPK inhibition during mouse preimplantation development .
19820125	0	Trps1	0,5	Bmp7	30,34	Trps1	Bmp7	83925(Tax:10090)	12162(Tax:10090)	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	Trps1 functions downstream of Bmp7 in kidney development .
17997399	0	Trps1	0,5	Stat3	68,73	Trps1	Stat3	83925(Tax:10090)	20848(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling .
21813735	0	Trs65p	0,6	Gea2p	85,90	Trs65p	Gea2p	853076(Tax:4932)	856691(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Trs65p , a subunit of the Ypt1p GEF TRAPPII , interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic .
20375281	0	Trs85	0,5	GEF	21,24	Trs85	GEF	22878	9181	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|END_ENTITY	Trs85 directs a Ypt1 GEF , TRAPPIII , to the phagophore to promote autophagy .
14660662	0	Trsp	54,58	Sec	49,52	Trsp	Sec	22069(Tax:10090)	65967(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Specific excision of the selenocysteine tRNA -LSB- Ser -RSB- Sec -LRB- Trsp -RRB- gene in mouse liver demonstrates an essential role of selenoproteins in liver function .
19696890	0	Trsp	75,79	selenocysteine_tRNA	49,68	Trsp	selenocysteine tRNA	22069(Tax:10090)	22069(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Osteo-chondroprogenitor-specific deletion of the selenocysteine_tRNA gene , Trsp , leads to chondronecrosis and abnormal skeletal development : a putative model for Kashin-Beck_disease .
12208766	0	Trx-1	102,107	vascular_endothelial_growth_factor	144,178	Trx-1	vascular endothelial growth factor	7295	7422	Gene	Gene	results|compound|START_ENTITY results|nmod|production production|compound|END_ENTITY	The redox protein thioredoxin-1 -LRB- Trx-1 -RRB- increases hypoxia-inducible factor 1alpha protein expression : Trx-1 overexpression results in increased vascular_endothelial_growth_factor production and enhanced tumor angiogenesis .
14726524	0	Trypsin_IV	0,10	protease-activated_receptors_2_and_4	31,67	Trypsin IV	protease-activated receptors 2 and 4	5646	2150;9002	Gene	Gene	START_ENTITY|appos|agonist agonist|nmod|END_ENTITY	Trypsin_IV , a novel agonist of protease-activated_receptors_2_and_4 .
18363639	0	Trypsinogen_IV	0,14	serotonin_transporter	16,37	Trypsinogen IV	serotonin transporter	5646	6532	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Trypsinogen_IV , serotonin_transporter transcript levels and serotonin content are increased in small intestine of irritable_bowel_syndrome patients .
25797204	0	Tryptase_1	25,35	TPSAB1	37,43	Tryptase 1	TPSAB1	7177	7177	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Alpha tryptase allele of Tryptase_1 -LRB- TPSAB1 -RRB- gene associated with Dengue_Hemorrhagic_Fever -LRB- DHF -RRB- and Dengue_Shock_Syndrome -LRB- DSS -RRB- in Vietnam and Philippines .
17134762	0	Tryptophan_hydroxylase_1	0,24	TPH1	31,35	Tryptophan hydroxylase 1	TPH1	7166	7166	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tryptophan_hydroxylase_1 gene -LRB- TPH1 -RRB- moderates the influence of social support on depressive_symptoms in adults .
17671363	0	Tsa1	106,110	thioredoxin_peroxidase_1	80,104	Tsa1	thioredoxin peroxidase 1	854980(Tax:4932)	854980(Tax:4932)	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	Crystallization and preliminary X-ray analysis of a decameric form of cytosolic thioredoxin_peroxidase_1 -LRB- Tsa1 -RRB- , C47S mutant , from Saccharomyces_cerevisiae .
15881652	0	Tsc-22	0,6	TGF-beta	16,24	Tsc-22	TGF-beta	21807(Tax:10090)	21803(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation .
19609361	0	Tsc1	24,28	Akt	0,3	Tsc1	Akt	42862(Tax:7227)	41957(Tax:7227)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt phosphorylates both Tsc1 and Tsc2 in Drosophila , but neither phosphorylation is required for normal animal growth .
10029074	0	Tsc1	90,94	tuberous_sclerosis_1	63,83	Tsc1	tuberous sclerosis 1	7248	7248	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of a rat homologue of the human tuberous_sclerosis_1 gene -LRB- Tsc1 -RRB- and analysis of its mutations in rat renal carcinomas .
19357198	0	Tsc2	24,28	AKT	78,81	Tsc2	AKT	7249	207	Gene	Gene	allele|nmod|START_ENTITY highlights|nsubj|allele highlights|advcl|signaling signaling|nmod|END_ENTITY	A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles .
12172554	0	Tsc2	49,53	Akt	0,3	Tsc2	Akt	40201(Tax:7227)	41957(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Akt regulates growth by directly phosphorylating Tsc2 .
15466161	0	Tsc2	0,4	Akt	33,36	Tsc2	Akt	40201(Tax:7227)	41957(Tax:7227)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Tsc2 is not a critical target of Akt during normal Drosophila development .
16027169	0	Tsc2	73,77	Akt	23,26	Tsc2	Akt	22084(Tax:10090)	11651(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY tumors|acl|lacking growth|nmod|tumors limits|dobj|growth limits|nsubj|inhibition inhibition|nmod|signaling signaling|compound|END_ENTITY	Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2 .
24632604	0	Tsc2	19,23	Akt	76,79	Tsc2	Akt	22084(Tax:10090)	11651(Tax:10090)	Gene	Gene	model|amod|START_ENTITY Renal_tumours|nmod|model show|nsubj|Renal_tumours show|dobj|inhibition inhibition|nmod|END_ENTITY	Renal_tumours in a Tsc2 -LRB- + / - -RRB- mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin .
7591959	0	Tsc2	40,44	tuberous_sclerosis	20,38	Tsc2	tuberous sclerosis	24855(Tax:10116)	24855(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Allelic loss at the tuberous_sclerosis -LRB- Tsc2 -RRB- gene locus in spontaneous uterine_leiomyosarcomas and pituitary_adenomas in the Eker rat model .
15908698	0	Tsg101	0,6	Gag	52,55	Tsg101	Gag	22088(Tax:10090)	17276(Tax:10090)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding .
18077552	0	Tsg101	14,20	Tsg101-associated_ligase	65,89	Tsg101	Tsg101-associated ligase	7251	90678	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of Tsg101 expression by the steadiness box : a role of Tsg101-associated_ligase .
21643473	0	Tsg101	80,86	Tumor_Susceptibility_Gene_101	49,78	Tsg101	Tumor Susceptibility Gene 101	7251	7251	Gene	Gene	Protein|appos|START_ENTITY Protein|compound|END_ENTITY	Elucidation of New Binding Interactions with the Tumor_Susceptibility_Gene_101 -LRB- Tsg101 -RRB- Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands .
18077552	0	Tsg101-associated_ligase	65,89	Tsg101	14,20	Tsg101-associated ligase	Tsg101	90678	7251	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Tsg101 expression by the steadiness box : a role of Tsg101-associated_ligase .
25305769	0	Tsga10	138,144	Testis_Specific_10	118,136	Tsga10	Testis Specific 10	211484(Tax:10090)	211484(Tax:10090)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Evaluation of in vitro Spermatogenesis System Effectiveness to Study Genes Behavior : Monitoring the Expression of the Testis_Specific_10 -LRB- Tsga10 -RRB- Gene as a Model .
11705455	0	Tsk	48,51	tight-skin	36,46	Tsk	tight-skin	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Reduction in dermal fibrosis in the tight-skin -LRB- Tsk -RRB- mouse after local application of halofuginone .
1617705	0	Tsk	107,110	tight-skin	95,105	Tsk	tight-skin	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	Granulated metrial gland cells in the pregnant uterus of mice expressing the collagen mutation tight-skin -LRB- Tsk / + -RRB- .
6604585	0	Tsk	83,86	tight-skin	71,81	Tsk	tight-skin	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Delayed-type_hypersensitivity to elastase-soluble lung peptides in the tight-skin -LRB- Tsk -RRB- mouse .
17705049	0	Tsk	50,53	tight_skin	38,48	Tsk	tight skin	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Marfan-like skeletal phenotype in the tight_skin -LRB- Tsk -RRB- mouse .
7902327	0	Tsk	16,19	tight_skin	4,14	Tsk	tight skin	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The tight_skin -LRB- Tsk -RRB- mutation in the mouse , a model for human fibrotic_diseases , is tightly linked to the beta 2-microglobulin -LRB- B2m -RRB- gene on chromosome 2 .
16127425	0	Tsk1	28,32	tight_skin	16,26	Tsk1	tight skin	22114(Tax:10090)	14118(Tax:10090)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|appos|+	Analysis of the tight_skin -LRB- Tsk1 / + -RRB- mouse as a model for testing antifibrotic agents .
15480416	0	Tsp68C	48,54	tetraspanin	35,46	Tsp68C	tetraspanin	117407(Tax:7227)	35614(Tax:7227)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of Drosophila tetraspanin , Tsp68C , suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes .
18795891	0	Tspan9	18,24	GPVI	83,87	Tspan9	GPVI	10867	51206	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains .
22378763	0	Tspo	52,56	translocator_protein	30,50	Tspo	translocator protein	12257(Tax:10090)	12257(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of translocator_protein -LRB- Tspo -RRB- via a SINE B2-mediated natural antisense transcript in MA-10 Leydig cells .
7488186	0	Tst	22,25	rhodanese	6,15	Tst	rhodanese	22117(Tax:10090)	22117(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mouse rhodanese gene -LRB- Tst -RRB- : cDNA cloning , sequencing , and recombinant protein expression .
7791781	0	Tst-1	54,59	Oct-6	60,65	Tst-1	Oct-6	100526790	5453	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|END_ENTITY	Functional interaction between the POU domain protein Tst-1 / Oct-6 and the high-mobility-group protein HMG-I/Y .
10866997	0	Tst-1	36,41	somatostatin_receptor_1	52,75	Tst-1	somatostatin receptor 1	100526790	6751	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	The POU domain transcription factor Tst-1 activates somatostatin_receptor_1 gene expression in pancreatic beta - cells .
22995554	0	Tsukushi	0,8	TGF-b1	47,53	Tsukushi	TGF-b1	25987	7040	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|regulating regulating|dobj|END_ENTITY	Tsukushi controls the hair cycle by regulating TGF-b1 signaling .
8670895	0	Tub4p	77,82	Spc98p	32,38	Tub4p	Spc98p	850909(Tax:4932)	855597(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces_cerevisiae at the sites of microtubule attachment .
20123021	0	Tuba1a	0,6	KLF6/7	39,45	Tuba1a	KLF6/7	573216(Tax:7955)	280650;553670	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish .
26373733	0	Tubb3	0,5	Erk	24,27	Tubb3	Erk	22152(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Tubb3 regulation by the Erk and Akt signaling pathways : a mechanism involved in the effect of arginine_ADP-ribosyltransferase_1 -LRB- Art1 -RRB- on apoptosis of colon_carcinoma CT26 cells .
26738854	0	Tuberous_Sclerosis_Complex-2	108,136	TSC-2	138,143	Tuberous Sclerosis Complex-2	TSC-2	7249	7249	Gene	Gene	Activation|compound|START_ENTITY Activation|appos|END_ENTITY	Hyperglycemia-Induced Oxidative-Nitrosative Stress Induces Inflammation_and_Neurodegeneration via Augmented Tuberous_Sclerosis_Complex-2 -LRB- TSC-2 -RRB- Activation in Neuronal Cells .
20808898	0	Tuberous_sclerosis_complex_1	0,28	dE2F1	39,44	Tuberous sclerosis complex 1	dE2F1	42862(Tax:7227)	42550(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tuberous_sclerosis_complex_1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival .
20530489	0	Tuberous_sclerosis_complex_2	0,28	CDC42	96,101	Tuberous sclerosis complex 2	CDC42	7249	998	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Tuberous_sclerosis_complex_2 -LRB- TSC2 -RRB- regulates cell migration and polarity through activation of CDC42 and RAC1 .
23355470	0	Tubulin_polymerization_promoting_protein_1	0,42	Tppp1	44,49	Tubulin polymerization promoting protein 1	Tppp1	11076	11076	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Tubulin_polymerization_promoting_protein_1 -LRB- Tppp1 -RRB- phosphorylation by Rho-associated coiled-coil kinase -LRB- rock -RRB- and cyclin-dependent_kinase 1 -LRB- Cdk1 -RRB- inhibits microtubule dynamics to increase cell proliferation .
23727580	0	Tubulin_polymerization_promoting_protein_1	0,42	b-catenin	61,70	Tubulin polymerization promoting protein 1	b-catenin	11076	1499	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Tubulin_polymerization_promoting_protein_1 -LRB- TPPP1 -RRB- increases b-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells .
20713507	0	Tudor	74,79	Aubergine	61,70	Tudor	Aubergine	37417(Tax:7227)	34524(Tax:7227)	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for methylarginine-dependent recognition of Aubergine by Tudor .
23555854	0	Tudor_domain-containing_protein_1	37,70	ERG	0,3	Tudor domain-containing protein 1	ERG	56165	2078	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	ERG induces epigenetic activation of Tudor_domain-containing_protein_1 -LRB- TDRD1 -RRB- in ERG rearrangement-positive prostate_cancer .
26096175	0	Tumor-Suppressor	9,25	PRDM1	0,5	Tumor-Suppressor	PRDM1	7248	639	Gene	Gene	Gene|compound|START_ENTITY END_ENTITY|appos|Gene	PRDM1 , a Tumor-Suppressor Gene , is Induced by Genkwadaphnin in Human Colon Cancer SW620 Cells .
25832642	0	Tumor-Suppressor	52,68	p53	81,84	Tumor-Suppressor	p53	7248	7157	Gene	Gene	Activity|amod|START_ENTITY Activity|nmod|END_ENTITY	Pseudokinase Tribbles_1 -LRB- TRB1 -RRB- Negatively Regulates Tumor-Suppressor Activity of p53 through p53 Deacetylation .
8913279	0	Tumor-associated_antigen_90K	0,28	THP-1	64,69	Tumor-associated antigen 90K	THP-1	3959	2736	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Tumor-associated_antigen_90K activates myelomonocytic cell line THP-1 .
19126414	0	Tumor-necrosis_factor-alpha	0,27	retinoic_acid-inducible_gene-I	36,66	Tumor-necrosis factor-alpha	retinoic acid-inducible gene-I	7124	23586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Tumor-necrosis_factor-alpha induces retinoic_acid-inducible_gene-I in rheumatoid fibroblast-like synoviocytes .
26976973	0	Tumor-suppressor	24,40	LKB1	46,50	Tumor-suppressor	LKB1	7248	6794	Gene	Gene	Correlates|compound|START_ENTITY Correlates|compound|END_ENTITY	Decreased Expression of Tumor-suppressor Gene LKB1 Correlates with Poor Prognosis in Human Gastric_Cancer .
26376749	0	Tumor_Necrosis_Factor-Alpha	10,37	Erythropoietin	41,55	Tumor Necrosis Factor-Alpha	Erythropoietin	7124	2056	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of Tumor_Necrosis_Factor-Alpha on Erythropoietin and Erythropoietin Receptor-Induced Erythroid Progenitor Cell Proliferation in b-Thalassemia/Hemoglobin E Patients .
26177712	0	Tumor_Necrosis_Factor-Alpha	0,27	ICAM-1	41,47	Tumor Necrosis Factor-Alpha	ICAM-1	7124	3383	Gene	Gene	Up-Regulates|compound|START_ENTITY END_ENTITY|nsubj|Up-Regulates	Tumor_Necrosis_Factor-Alpha Up-Regulates ICAM-1 Expression and Release in Intestinal Myofibroblasts by Redox-Dependent and - Independent Mechanisms .
21907587	0	Tumor_Necrosis_Factor-alpha	12,39	TNF-a	41,46	Tumor Necrosis Factor-alpha	TNF-a	7124	7124	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of Tumor_Necrosis_Factor-alpha -LRB- TNF-a -RRB- in the pathogenesis of systemic_lupus_erythematosus .
11570978	0	Tumor_Necrosis_Factor-alpha	26,53	TNF-alpha	55,64	Tumor Necrosis Factor-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The G-308A variant of the Tumor_Necrosis_Factor-alpha -LRB- TNF-alpha -RRB- gene is not associated with obesity , insulin resistance and body fat distribution .
25503683	0	Tumor_Necrosis_Factor_Alpha	12,39	Tamm-Horsfall_Protein	72,93	Tumor Necrosis Factor Alpha	Tamm-Horsfall Protein	21926(Tax:10090)	22242(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Expression Expression|nmod|END_ENTITY	The Role of Tumor_Necrosis_Factor_Alpha in Regulating the Expression of Tamm-Horsfall_Protein -LRB- Uromodulin -RRB- in Thick Ascending Limbs during Kidney_Injury .
20006573	0	Tumor_Necrosis_Factor_alpha	0,27	CD40	49,53	Tumor Necrosis Factor alpha	CD40	7124	958	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Tumor_Necrosis_Factor_alpha -LRB- TNFalpha -RRB- regulates CD40 expression through SMAR1 phosphorylation .
26107164	0	Tumor_Suppressor	16,32	RASSF1A	39,46	Tumor Suppressor	RASSF1A	7248	11186	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Correction : The Tumor_Suppressor Gene , RASSF1A , Is Essential for Protection against Inflammation _ - Induced_Injury .
25179905	0	Tumor_Suppressor	0,16	p53	25,28	Tumor Suppressor	p53	7248	7157	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Tumor_Suppressor Protein p53 Promotes 2-Methoxyestradiol-Induced Activation of Bak and Bax , Leading to Mitochondria-Dependent Apoptosis in Human Colon Cancer HCT116 Cells .
21643473	0	Tumor_Susceptibility_Gene_101	49,78	Tsg101	80,86	Tumor Susceptibility Gene 101	Tsg101	7251	7251	Gene	Gene	Protein|compound|START_ENTITY Protein|appos|END_ENTITY	Elucidation of New Binding Interactions with the Tumor_Susceptibility_Gene_101 -LRB- Tsg101 -RRB- Protein Using Modified HIV-1 Gag-p6 Derived Peptide Ligands .
10383455	0	Tumor_necrosis_factor	0,21	BAD	67,70	Tumor necrosis factor	BAD	7124	572	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tumor_necrosis_factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-OH_kinase-dependent pathway .
10085086	0	Tumor_necrosis_factor	0,21	Bcl-2	30,35	Tumor necrosis factor	Bcl-2	7124	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons .
14550262	0	Tumor_necrosis_factor	0,21	Bcl-2	108,113	Tumor necrosis factor	Bcl-2	7124	596	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|increases increases|nmod|proteins proteins|compound|END_ENTITY	Tumor_necrosis_factor attenuates prion_protein-deficient neuronal cell death by increases in anti-apoptotic Bcl-2 family proteins .
23620528	0	Tumor_necrosis_factor	0,21	CD137	49,54	Tumor necrosis factor	CD137	7124	3604	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	Tumor_necrosis_factor receptor 1 associates with CD137 ligand and mediates its reverse signaling .
23494522	0	Tumor_necrosis_factor	0,21	CD4	52,55	Tumor necrosis factor	CD4	7124	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Tumor_necrosis_factor receptor type I expression of CD4 + T cells in rheumatoid_arthritis enables them to follow tumor_necrosis_factor gradients into the rheumatoid synovium .
10891891	0	Tumor_necrosis_factor	0,21	CD_20	32,37	Tumor necrosis factor	CD 20	7124	54474	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Tumor_necrosis_factor modulates CD_20 expression on cells from chronic_lymphocytic_leukemia : a new role for TNF_alpha ?
14761884	0	Tumor_necrosis_factor	0,21	CRE-binding_protein	32,51	Tumor necrosis factor	CRE-binding protein	7124	1385	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Tumor_necrosis_factor activates CRE-binding_protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells .
24753255	0	Tumor_necrosis_factor	0,21	CXCL10	43,49	Tumor necrosis factor	CXCL10	7124	3627	Gene	Gene	START_ENTITY|dep|induction induction|nmod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- - a induction of CXCL10 in endothelial cells requires protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- - mediated nuclear factor -LRB- NF -RRB- - kB p65 methylation .
2493502	0	Tumor_necrosis_factor	0,21	IFN-gamma	48,57	Tumor necrosis factor	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Tumor_necrosis_factor synergistically acts with IFN-gamma to regulate Ly-6A / E expression in T lymphocytes , thymocytes and bone marrow cells .
3099296	0	Tumor_necrosis_factor	0,21	MYC	31,34	Tumor necrosis factor	MYC	7124	4609	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription .
10085086	0	Tumor_necrosis_factor	0,21	NFkappaB	65,73	Tumor necrosis factor	NFkappaB	7124	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|compound|END_ENTITY	Tumor_necrosis_factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons .
15289505	0	Tumor_necrosis_factor	0,21	TNF	23,26	Tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious_and_inflammatory_diseases .
10891891	0	Tumor_necrosis_factor	0,21	TNF_alpha	108,117	Tumor necrosis factor	TNF alpha	7124	7124	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Tumor_necrosis_factor modulates CD_20 expression on cells from chronic_lymphocytic_leukemia : a new role for TNF_alpha ?
3097823	0	Tumor_necrosis_factor	0,21	c-myc	30,35	Tumor necrosis factor	c-myc	7124	4609	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor reduces c-myc expression and cooperates with interferon-gamma in HeLa cells .
1855214	0	Tumor_necrosis_factor	0,21	cachectin	22,31	Tumor necrosis factor	cachectin	103694380	24835(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|decreases decreases|nsubj|END_ENTITY	Tumor_necrosis_factor / cachectin decreases catalase activity of rat liver .
2475571	0	Tumor_necrosis_factor	0,21	cachectin	22,31	Tumor necrosis factor	cachectin	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|plays plays|nsubj|END_ENTITY	Tumor_necrosis_factor / cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis .
3119758	0	Tumor_necrosis_factor	0,21	cachectin	22,31	Tumor necrosis factor	cachectin	103694380	24835(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|stimulates stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor / cachectin stimulates peritoneal macrophages , polymorphonuclear neutrophils , and vascular endothelial cells to synthesize and release platelet-activating factor .
1705566	0	Tumor_necrosis_factor	0,21	granulocyte-colony-stimulating_factor	36,73	Tumor necrosis factor	granulocyte-colony-stimulating factor	7124	1440	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor downregulates granulocyte-colony-stimulating_factor receptor expression on human acute_myeloid_leukemia cells and granulocytes .
2304467	0	Tumor_necrosis_factor	0,21	hsp28	92,97	Tumor necrosis factor	hsp28	7124	3315	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tumor_necrosis_factor induces the rapid phosphorylation of the mammalian heat_shock protein hsp28 .
3097823	0	Tumor_necrosis_factor	0,21	interferon-gamma	67,83	Tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Tumor_necrosis_factor reduces c-myc expression and cooperates with interferon-gamma in HeLa cells .
21153161	0	Tumor_necrosis_factor	0,21	interleukin-6	32,45	Tumor necrosis factor	interleukin-6	103694380	24498(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Tumor_necrosis_factor increases interleukin-6 release from adrenal zona glomerulosa cellsin vitro .
2550484	0	Tumor_necrosis_factor	0,21	interleukin_1	89,102	Tumor necrosis factor	interleukin 1	7124	3552	Gene	Gene	causes|nsubj|START_ENTITY causes|nmod|END_ENTITY	Tumor_necrosis_factor causes amplification of arachidonic_acid metabolism in response to interleukin_1 , bradykinin , and other agonists .
21628458	0	Tumor_necrosis_factor	0,21	interleukin_17C	46,61	Tumor necrosis factor	interleukin 17C	7124	27189	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Tumor_necrosis_factor a-mediated induction of interleukin_17C in human keratinocytes is controlled by nuclear factor kB .
1874802	0	Tumor_necrosis_factor	0,21	ornithine_decarboxylase	33,56	Tumor necrosis factor	ornithine decarboxylase	7124	4953	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Tumor_necrosis_factor stimulates ornithine_decarboxylase activity in human fibroblasts and tumor target cells .
23611870	0	Tumor_necrosis_factor	0,21	p55	80,83	Tumor necrosis factor	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	START_ENTITY|dep|effects effects|nmod|deletion deletion|nmod|receptor receptor|amod|END_ENTITY	Tumor_necrosis_factor in traumatic_brain_injury : effects of genetic deletion of p55 or p75 receptor .
7504889	0	Tumor_necrosis_factor	0,21	p55	68,71	Tumor necrosis factor	p55	7124	7132	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|receptor receptor|amod|END_ENTITY	Tumor_necrosis_factor activates human endothelial cells through the p55 tumor_necrosis_factor receptor but the p75 receptor contributes to activation at low tumor_necrosis_factor concentration .
8300617	0	Tumor_necrosis_factor	0,21	p75	58,61	Tumor necrosis factor	p75	7124	7133	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|selective selective|nmod|receptor receptor|amod|END_ENTITY	Tumor_necrosis_factor induces a selective shedding of its p75 receptor from human neutrophils .
8381414	0	Tumor_necrosis_factor	0,21	p75	59,62	Tumor necrosis factor	p75	7124	7133	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- up-regulates the expression of p75 but not p55 TNF receptors , and both receptors mediate , independently of each other , up-regulation of transforming_growth_factor_alpha and epidermal_growth_factor_receptor mRNA .
3140909	0	Tumor_necrosis_factor	0,21	plasminogen_activator_inhibitor	50,81	Tumor necrosis factor	plasminogen activator inhibitor	7124	5054	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|nmod|END_ENTITY	Tumor_necrosis_factor increases the production of plasminogen_activator_inhibitor in human endothelial cells in vitro and in rats in vivo .
2854203	0	Tumor_necrosis_factor	0,21	thrombomodulin	54,68	Tumor necrosis factor	thrombomodulin	7124	7056	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Tumor_necrosis_factor suppresses transcription of the thrombomodulin gene in endothelial cells .
1732009	0	Tumor_necrosis_factor	0,21	urokinase-type_plasminogen_activator	52,88	Tumor necrosis factor	urokinase-type plasminogen activator	7124	5328	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Tumor_necrosis_factor induction of endothelial cell urokinase-type_plasminogen_activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon .
1801706	0	Tumor_necrosis_factor	0,21	urokinase-type_plasminogen_activator	35,71	Tumor necrosis factor	urokinase-type plasminogen activator	7124	5328	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Tumor_necrosis_factor induction of urokinase-type_plasminogen_activator in human endothelial cells .
2140060	0	Tumor_necrosis_factor	0,21	urokinase-type_plasminogen_activator	48,84	Tumor necrosis factor	urokinase-type plasminogen activator	7124	5328	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Tumor_necrosis_factor induces the production of urokinase-type_plasminogen_activator by human endothelial cells .
24126638	0	Tumor_necrosis_factor-a	0,23	ADAMTS-4	32,40	Tumor necrosis factor-a	ADAMTS-4	7124	9507	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor-a induces ADAMTS-4 expression in human osteoarthritis chondrocytes .
26918940	0	Tumor_necrosis_factor-a	0,23	CA125	58,63	Tumor necrosis factor-a	CA125	7124	94025	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tumor_necrosis_factor-a and interferon-y stimulate MUC16 -LRB- CA125 -RRB- expression in breast , endometrial_and_ovarian_cancers through NFkB .
23946597	0	Tumor_necrosis_factor-a	0,23	JNK	33,36	Tumor necrosis factor-a	JNK	24835(Tax:10116)	116554(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Tumor_necrosis_factor-a mediates JNK activation response to intestinal_ischemia-reperfusion injury .
26918940	0	Tumor_necrosis_factor-a	0,23	MUC16	51,56	Tumor necrosis factor-a	MUC16	7124	94025	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Tumor_necrosis_factor-a and interferon-y stimulate MUC16 -LRB- CA125 -RRB- expression in breast , endometrial_and_ovarian_cancers through NFkB .
20722069	0	Tumor_necrosis_factor-a	0,23	NHE2	52,56	Tumor necrosis factor-a	NHE2	7124	6549	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-a represses the expression of NHE2 through NF-kB activation in intestinal epithelial cell model , C2BBe1 .
24102429	0	Tumor_necrosis_factor-a	0,23	RANKL	33,38	Tumor necrosis factor-a	RANKL	7124	8600	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a enhances RANKL expression in gingival epithelial cells via protein kinase A signaling .
22903530	0	Tumor_necrosis_factor-a	0,23	Snail	91,96	Tumor necrosis factor-a	Snail	7124	6615	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Tumor_necrosis_factor-a -LRB- TNF-a -RRB- stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma .
24139907	0	Tumor_necrosis_factor-a	0,23	TNF-a	25,30	Tumor necrosis factor-a	TNF-a	7124	7124	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Tumor_necrosis_factor-a -LRB- TNF-a -RRB- -863 C/A promoter polymorphism is associated with type 2 diabetes in Tunisian population .
21335064	0	Tumor_necrosis_factor-a	0,23	brain-derived_neurotrophic_factor	34,67	Tumor necrosis factor-a	brain-derived neurotrophic factor	24835(Tax:10116)	24225(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a increases brain-derived_neurotrophic_factor expression in trigeminal_ganglion neurons in an activity-dependent manner .
25948735	0	Tumor_necrosis_factor-a	0,23	claudin-2	53,62	Tumor necrosis factor-a	claudin-2	397086(Tax:9823)	733684(Tax:9823)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a induces a biphasic change in claudin-2 expression in tubular epithelial cells : role in barrier functions .
27060290	0	Tumor_necrosis_factor-a	0,23	extracellular_signal-regulated_kinase	68,105	Tumor necrosis factor-a	extracellular signal-regulated kinase	7124	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Tumor_necrosis_factor-a regulates interleukin-33 expression through extracellular_signal-regulated_kinase , p38 , and nuclear factor-kB pathways in airway epithelial cells .
27060290	0	Tumor_necrosis_factor-a	0,23	interleukin-33	34,48	Tumor necrosis factor-a	interleukin-33	7124	90865	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a regulates interleukin-33 expression through extracellular_signal-regulated_kinase , p38 , and nuclear factor-kB pathways in airway epithelial cells .
24970360	0	Tumor_necrosis_factor-a	0,23	interleukin-34	32,46	Tumor necrosis factor-a	interleukin-34	21926(Tax:10090)	76527(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a induces interleukin-34 expression through nuclear factor - kB activation in MC3T3-E1 osteoblastic cells .
21191629	0	Tumor_necrosis_factor-a	0,23	interleukin-6	58,71	Tumor necrosis factor-a	interleukin-6	7124	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Tumor_necrosis_factor-a induces expression and release of interleukin-6 by human urothelial cells .
21494319	0	Tumor_necrosis_factor-a	0,23	nuclear_factor-kB	62,79	Tumor necrosis factor-a	nuclear factor-kB	24835(Tax:10116)	81736(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor-a induces transcriptional activation of nuclear_factor-kB in insulin-producing b-cells .
21075101	0	Tumor_necrosis_factor-a	0,23	p27	34,37	Tumor necrosis factor-a	p27	7124	3429	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a regulates p27 kip expression and apoptosis in smooth muscle cells of human carotid plaques via forkhead transcription factor O1 .
21542902	0	Tumor_necrosis_factor-a	0,23	visfatin	59,67	Tumor necrosis factor-a	visfatin	7124	10135	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells .
25536447	0	Tumor_necrosis_factor-a-induced_protein-8_like-2	0,48	p27	69,72	Tumor necrosis factor-a-induced protein-8 like-2	p27	79626	3429	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	Tumor_necrosis_factor-a-induced_protein-8_like-2 -LRB- TIPE2 -RRB- upregulates p27 to decrease gastic_cancer cell proliferation .
21777519	0	Tumor_necrosis_factor-a_converting_enzyme	0,41	RANKL	59,64	Tumor necrosis factor-a converting enzyme	RANKL	6868	8600	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a_converting_enzyme -LRB- TACE -RRB- increases RANKL expression in osteoblasts and serves as a potential biomarker of periodontitis .
19088256	0	Tumor_necrosis_factor-alpha	0,27	11beta-hydroxysteroid_dehydrogenase_type_1	40,82	Tumor necrosis factor-alpha	11beta-hydroxysteroid dehydrogenase type 1	7124	3290	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha upregulates 11beta-hydroxysteroid_dehydrogenase_type_1 expression by CCAAT/enhancer _ binding_protein-beta in HepG2 cells .
25173154	0	Tumor_necrosis_factor-alpha	0,27	C/EBP-beta	50,60	Tumor necrosis factor-alpha	C/EBP-beta	7124	1051	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces expression of C/EBP-beta in primary afferent neurons following_nerve_injury .
18164590	0	Tumor_necrosis_factor-alpha	0,27	CCL3	124,128	Tumor necrosis factor-alpha	CCL3	7124	6348	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- induces integrin CD11b/CD18 -LRB- Mac-1 -RRB- up-regulation and migration to the CC chemokine CCL3 -LRB- MIP-1alpha -RRB- on human neutrophils through defined signalling pathways .
11571308	0	Tumor_necrosis_factor-alpha	0,27	CD34	98,102	Tumor necrosis factor-alpha	CD34	7124	947	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|ligand ligand|nmod|END_ENTITY	Tumor_necrosis_factor-alpha regulates the expression of inducible_costimulator_receptor ligand on CD34 -LRB- + -RRB- progenitor cells during differentiation into antigen presenting cells .
12423676	0	Tumor_necrosis_factor-alpha	0,27	CD34	75,79	Tumor necrosis factor-alpha	CD34	7124	947	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|compound|END_ENTITY	Tumor_necrosis_factor-alpha inhibits generation of glycophorin A + cells by CD34 + cells .
1693526	0	Tumor_necrosis_factor-alpha	0,27	CD34	147,151	Tumor necrosis factor-alpha	CD34	7124	947	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|proliferation proliferation|nmod|hematopoietic_progenitor_cells hematopoietic_progenitor_cells|compound|END_ENTITY	Tumor_necrosis_factor-alpha strongly potentiates interleukin-3 and granulocyte-macrophage_colony-stimulating_factor-induced proliferation of human CD34 + hematopoietic_progenitor_cells .
15266023	0	Tumor_necrosis_factor-alpha	0,27	CD38	172,176	Tumor necrosis factor-alpha	CD38	7124	952	Gene	Gene	differentially|amod|START_ENTITY regulates|nsubj|differentially regulates|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Tumor_necrosis_factor-alpha differentially regulates the expression of proinflammatory genes in human airway_smooth_muscle cells by activation of interferon-beta-dependent CD38 pathway .
12867430	0	Tumor_necrosis_factor-alpha	0,27	CD44	76,80	Tumor necrosis factor-alpha	CD44	7124	960	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Tumor_necrosis_factor-alpha induces functionally active hyaluronan-adhesive CD44 by activating sialidase through p38_mitogen-activated_protein_kinase in lipopolysaccharide-stimulated human monocytic cells .
16908592	0	Tumor_necrosis_factor-alpha	0,27	CD44	53,57	Tumor necrosis factor-alpha	CD44	7124	960	Gene	Gene	differentially|amod|START_ENTITY modulates|nsubj|differentially modulates|dobj|expression expression|nummod|END_ENTITY	Tumor_necrosis_factor-alpha differentially modulates CD44 expression in ovarian_cancer cells .
16806199	0	Tumor_necrosis_factor-alpha	0,27	CTRP1	60,65	Tumor necrosis factor-alpha	CTRP1	24835(Tax:10116)	303701(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Tumor_necrosis_factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue .
9761760	0	Tumor_necrosis_factor-alpha	0,27	Clara_cell_secretory_protein	45,73	Tumor necrosis factor-alpha	Clara cell secretory protein	7124	7356	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Tumor_necrosis_factor-alpha stimulates human Clara_cell_secretory_protein production by human airway epithelial cells .
11753679	0	Tumor_necrosis_factor-alpha	0,27	DR6	54,57	Tumor necrosis factor-alpha	DR6	7124	27242	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of DR6 , a member of the TNF receptor family , through activation of NF-kappaB .
10544014	0	Tumor_necrosis_factor-alpha	0,27	Fas_ligand	81,91	Tumor necrosis factor-alpha	Fas ligand	7124	356	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha and interferon-gamma induce expression of functional Fas_ligand on HT29 and MCF7 adenocarcinoma cells .
8995440	0	Tumor_necrosis_factor-alpha	0,27	GLUT1	63,68	Tumor necrosis factor-alpha	GLUT1	7124	6513	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Tumor_necrosis_factor-alpha regulation of glucose_transporter -LRB- GLUT1 -RRB- mRNA turnover .
12111363	0	Tumor_necrosis_factor-alpha	0,27	ICAM-1	62,68	Tumor necrosis factor-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF -RRB- regulates the expression of ICAM-1 predominantly through TNF receptor 1 after chronic constriction_injury_of_mouse_sciatic_nerve .
8095156	0	Tumor_necrosis_factor-alpha	0,27	ICAM-1	39,45	Tumor necrosis factor-alpha	ICAM-1	7124	3383	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor-alpha stimulates ICAM-1 expression in human vascular smooth muscle cells .
10454343	0	Tumor_necrosis_factor-alpha	0,27	IFN-gamma	43,52	Tumor necrosis factor-alpha	IFN-gamma	7124	3458	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|complex complex|amod|END_ENTITY	Tumor_necrosis_factor-alpha signals to the IFN-gamma receptor complex to increase Stat1alpha activation .
1387149	0	Tumor_necrosis_factor-alpha	0,27	IFN-gamma	49,58	Tumor necrosis factor-alpha	IFN-gamma	7124	3458	Gene	Gene	up-regulate|nsubj|START_ENTITY up-regulate|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha and IL-6 up-regulate IFN-gamma receptor gene expression in human monocytic THP-1 cells by transcriptional and post-transcriptional mechanisms .
1918966	0	Tumor_necrosis_factor-alpha	0,27	IFN-gamma	65,74	Tumor necrosis factor-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	triggers|nsubj|START_ENTITY triggers|dobj|activity activity|nmod|macrophages macrophages|amod|primed primed|advmod|END_ENTITY	Tumor_necrosis_factor-alpha triggers antitoxoplasmal activity of IFN-gamma primed macrophages .
1968489	0	Tumor_necrosis_factor-alpha	0,27	IL-2	107,111	Tumor necrosis factor-alpha	IL-2	21926(Tax:10090)	16183(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|END_ENTITY	Tumor_necrosis_factor-alpha and P40 induce day 15 murine fetal thymocyte proliferation in combination with IL-2 .
18336852	0	Tumor_necrosis_factor-alpha	0,27	MMP-9	36,41	Tumor necrosis factor-alpha	MMP-9	7124	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor-alpha induces MMP-9 expression via p42/p44 _ MAPK , JNK , and nuclear factor-kappaB in A549 cells .
11264281	0	Tumor_necrosis_factor-alpha	0,27	MnSOD	48,53	Tumor necrosis factor-alpha	MnSOD	7124	6648	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor-alpha selectively induces MnSOD expression via mitochondria-to-nucleus signaling , whereas interleukin-1beta utilizes an alternative pathway .
11753679	0	Tumor_necrosis_factor-alpha	0,27	NF-kappaB	118,127	Tumor necrosis factor-alpha	NF-kappaB	7124	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of DR6 , a member of the TNF receptor family , through activation of NF-kappaB .
10823840	0	Tumor_necrosis_factor-alpha	0,27	NF-kappa_B	42,52	Tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha activation of NF-kappa_B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel .
11087727	0	Tumor_necrosis_factor-alpha	0,27	NF-kappa_B	48,58	Tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Tumor_necrosis_factor-alpha induces distinctive NF-kappa_B signaling within human dermal fibroblasts .
1751774	0	Tumor_necrosis_factor-alpha	0,27	NF-kappa_B	104,114	Tumor necrosis factor-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	activators|nsubj|START_ENTITY activators|nmod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin_1 , and phorbol_myristate_acetate are independent activators of NF-kappa_B which differentially activate T cells .
14563845	0	Tumor_necrosis_factor-alpha	0,27	NFkappaB	38,46	Tumor necrosis factor-alpha	NFkappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Tumor_necrosis_factor-alpha activates NFkappaB to inhibit renin transcription by targeting cAMP-responsive element .
21607023	0	Tumor_necrosis_factor-alpha	0,27	TNF-a	29,34	Tumor necrosis factor-alpha	TNF-a	7124	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- levels in aqueous_humor of primary_open_angle_glaucoma .
26618585	0	Tumor_necrosis_factor-alpha	0,27	TNFa	29,33	Tumor necrosis factor-alpha	TNFa	280943(Tax:9913)	280943(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNFa -RRB- gene polymorphism and expression of membrane-bound TNFa protein on CD11b + and IgM + cells in cows naturally infected_with_bovine_leukemia_virus .
12855710	0	Tumor_necrosis_factor-alpha	0,27	TRPC1	68,73	Tumor necrosis factor-alpha	TRPC1	7124	7220	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor-alpha induces nuclear_factor-kappaB-dependent TRPC1 expression in endothelial cells .
20004646	0	Tumor_necrosis_factor-alpha	0,27	alkaline_phosphatase	38,58	Tumor necrosis factor-alpha	alkaline phosphatase	7124	250	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Tumor_necrosis_factor-alpha increases alkaline_phosphatase expression in vascular smooth muscle cells via MSX2 induction .
10708557	0	Tumor_necrosis_factor-alpha	0,27	angiopoietin-2	40,54	Tumor necrosis factor-alpha	angiopoietin-2	7124	285	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|xcomp|END_ENTITY	Tumor_necrosis_factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells .
11279049	0	Tumor_necrosis_factor-alpha	0,27	aquaporin_5	37,48	Tumor necrosis factor-alpha	aquaporin 5	21926(Tax:10090)	11830(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits aquaporin_5 expression in mouse lung epithelial cells .
17557910	0	Tumor_necrosis_factor-alpha	0,27	aryl_hydrocarbon_receptor	49,74	Tumor necrosis factor-alpha	aryl hydrocarbon receptor	24835(Tax:10116)	25690(Tax:10116)	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Tumor_necrosis_factor-alpha modulates effects of aryl_hydrocarbon_receptor ligands on cell proliferation and expression of cytochrome_P450 enzymes in rat liver `` stem-like '' cells .
2019266	0	Tumor_necrosis_factor-alpha	0,27	bone_Gla_protein	73,89	Tumor necrosis factor-alpha	bone Gla protein	24835(Tax:10116)	25295(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|compound|END_ENTITY	Tumor_necrosis_factor-alpha inhibits 1,25-dihydroxyvitamin _ D3-stimulated bone_Gla_protein synthesis in rat_osteosarcoma cells -LRB- ROS 17/2 .8 -RRB- by a pretranslational mechanism .
16461346	0	Tumor_necrosis_factor-alpha	0,27	c-Fms	176,181	Tumor necrosis factor-alpha	c-Fms	21926(Tax:10090)	12978(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY increases|acl|circulating circulating|advcl|promoting promoting|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha increases circulating osteoclast_precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression .
16029216	0	Tumor_necrosis_factor-alpha	0,27	c-Jun	99,104	Tumor necrosis factor-alpha	c-Jun	21926(Tax:10090)	16476(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY knockout|compound|receptor decreases|nsubj|knockout decreases|dobj|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha receptor 1 -LRB- p55 -RRB- knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons .
9388498	0	Tumor_necrosis_factor-alpha	0,27	c-fms	36,41	Tumor necrosis factor-alpha	c-fms	21926(Tax:10090)	12978(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces c-fms RNA expression in murine tissue macrophages .
7943321	0	Tumor_necrosis_factor-alpha	0,27	c-jun	36,41	Tumor necrosis factor-alpha	c-jun	7124	3725	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Tumor_necrosis_factor-alpha induces c-jun during the regenerative response to liver_injury .
11493024	0	Tumor_necrosis_factor-alpha	0,27	cFOS	36,40	Tumor necrosis factor-alpha	cFOS	24835(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Tumor_necrosis_factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord .
2154202	0	Tumor_necrosis_factor-alpha	0,27	cachectin	28,37	Tumor necrosis factor-alpha	cachectin	7124	7124	Gene	Gene	START_ENTITY|parataxis|activates activates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha / cachectin activates the O2 -LRB- - -RRB- - generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic_acid .
7529022	0	Tumor_necrosis_factor-alpha	0,27	carbonic_anhydrase_II	54,75	Tumor necrosis factor-alpha	carbonic anhydrase II	7124	760	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of carbonic_anhydrase_II in pancreatic_adenocarcinoma cells .
14505549	0	Tumor_necrosis_factor-alpha	1,28	caspase-3	30,39	Tumor necrosis factor-alpha	caspase-3	21926(Tax:10090)	12367(Tax:10090)	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	-LSB- Tumor_necrosis_factor-alpha , caspase-3 expression and hepatocyte apoptosis in fulminanting hepatic_failure -RSB- .
19049962	0	Tumor_necrosis_factor-alpha	0,27	cyclin-dependent_kinase_5	38,63	Tumor necrosis factor-alpha	cyclin-dependent kinase 5	21926(Tax:10090)	12568(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Tumor_necrosis_factor-alpha regulates cyclin-dependent_kinase_5 activity during pain signaling through transcriptional activation of p35 .
11356928	0	Tumor_necrosis_factor-alpha	0,27	cyclooxygenase-2	36,52	Tumor necrosis factor-alpha	cyclooxygenase-2	280943(Tax:9913)	282023(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells .
22800939	0	Tumor_necrosis_factor-alpha	0,27	cyclooxygenase-2	42,58	Tumor necrosis factor-alpha	cyclooxygenase-2	21926(Tax:10090)	19225(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces renal cyclooxygenase-2 expression in response to hypercalcemia .
9440135	0	Tumor_necrosis_factor-alpha	0,27	cyclooxygenase-2	47,63	Tumor necrosis factor-alpha	cyclooxygenase-2	7124	5743	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha promotes sustained cyclooxygenase-2 expression : attenuation by dexamethasone and NSAIDs .
8611631	0	Tumor_necrosis_factor-alpha	0,27	cytosolic_phospholipase_A2	47,73	Tumor necrosis factor-alpha	cytosolic phospholipase A2	7124	5321	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces the 85-kDa cytosolic_phospholipase_A2 gene expression in human bronchial epithelial cells .
8275950	0	Tumor_necrosis_factor-alpha	0,27	decidual_prolactin	72,90	Tumor necrosis factor-alpha	decidual prolactin	7124	5617	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|synthesis synthesis|nmod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits the synthesis and release of human decidual_prolactin .
14581470	0	Tumor_necrosis_factor-alpha	0,27	endothelial_nitric-oxide_synthase	37,70	Tumor necrosis factor-alpha	endothelial nitric-oxide synthase	280943(Tax:9913)	287024(Tax:9913)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits endothelial_nitric-oxide_synthase gene promoter activity in bovine aortic endothelial cells .
11912559	0	Tumor_necrosis_factor-alpha	0,27	endothelial_nitric_oxide_synthase	65,98	Tumor necrosis factor-alpha	endothelial nitric oxide synthase	7124	4846	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits insulin-induced increase in endothelial_nitric_oxide_synthase and reduces insulin_receptor content and phosphorylation in human aortic endothelial cells .
11278471	0	Tumor_necrosis_factor-alpha	0,27	ephrin_A1	53,62	Tumor necrosis factor-alpha	ephrin A1	7124	1942	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha induction of endothelial ephrin_A1 expression is mediated by a p38 MAPK - and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism .
14534369	0	Tumor_necrosis_factor-alpha	0,27	extracellular_signal-regulated_kinase	112,149	Tumor necrosis factor-alpha	extracellular signal-regulated kinase	7124	5594	Gene	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	Tumor_necrosis_factor-alpha and troglitazone_regulate plasminogen_activator_inhibitor_type_1 production through extracellular_signal-regulated_kinase - and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells .
10905491	0	Tumor_necrosis_factor-alpha	0,27	focal_adhesion_kinase	163,184	Tumor necrosis factor-alpha	focal adhesion kinase	24835(Tax:10116)	25614(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces hepatic insulin resistance in obese Zucker -LRB- fa/fa -RRB- rats via interaction of leukocyte_antigen-related_tyrosine_phosphatase with focal_adhesion_kinase .
17438336	0	Tumor_necrosis_factor-alpha	0,27	focal_adhesion_kinase	39,60	Tumor necrosis factor-alpha	focal adhesion kinase	7124	5747	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Tumor_necrosis_factor-alpha stimulates focal_adhesion_kinase activity required for mitogen-activated kinase-associated interleukin_6 expression .
12631113	0	Tumor_necrosis_factor-alpha	0,27	fractalkine	39,50	Tumor necrosis factor-alpha	fractalkine	7124	6376	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Tumor_necrosis_factor-alpha stimulates fractalkine production by mesangial cells and regulates monocyte transmigration : down-regulation by cAMP .
8995440	0	Tumor_necrosis_factor-alpha	0,27	glucose_transporter	42,61	Tumor necrosis factor-alpha	glucose transporter	7124	6513	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha regulation of glucose_transporter -LRB- GLUT1 -RRB- mRNA turnover .
11754394	0	Tumor_necrosis_factor-alpha	0,27	granulocyte-macrophage_colony-stimulating_factor	114,162	Tumor necrosis factor-alpha	granulocyte-macrophage colony-stimulating factor	7124	1437	Gene	Gene	levels|amod|START_ENTITY levels|dep|modulation modulation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha levels in long-term marrow cultures from patients with aplastic_anemia : modulation by granulocyte-macrophage_colony-stimulating_factor .
2752985	0	Tumor_necrosis_factor-alpha	0,27	growth_hormone	37,51	Tumor necrosis factor-alpha	growth hormone	24835(Tax:10116)	81668(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits growth_hormone secretion from cultured anterior pituitary cells .
16020509	0	Tumor_necrosis_factor-alpha	0,27	hTERT	37,42	Tumor necrosis factor-alpha	hTERT	7124	7015	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells .
11095498	0	Tumor_necrosis_factor-alpha	0,27	iNOS	75,79	Tumor necrosis factor-alpha	iNOS	7124	4843	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	Tumor_necrosis_factor-alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma cells .
11571308	0	Tumor_necrosis_factor-alpha	0,27	inducible_costimulator_receptor	56,87	Tumor necrosis factor-alpha	inducible costimulator receptor	7124	29851	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|compound|END_ENTITY	Tumor_necrosis_factor-alpha regulates the expression of inducible_costimulator_receptor ligand on CD34 -LRB- + -RRB- progenitor cells during differentiation into antigen presenting cells .
10419100	0	Tumor_necrosis_factor-alpha	0,27	insulin	45,52	Tumor necrosis factor-alpha	insulin	7124	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Tumor_necrosis_factor-alpha and ceramides in insulin resistance .
11889017	0	Tumor_necrosis_factor-alpha	0,27	insulin-like_growth_factor-1_and_insulin-like_growth_factor_binding_protein-3	38,115	Tumor necrosis factor-alpha	insulin-like growth factor-1 and insulin-like growth factor binding protein-3	24835(Tax:10116)	24482;24484	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha regulates insulin-like_growth_factor-1_and_insulin-like_growth_factor_binding_protein-3 expression in vascular smooth muscle .
1282723	0	Tumor_necrosis_factor-alpha	0,27	intercellular_adhesion_molecule-1	58,91	Tumor necrosis factor-alpha	intercellular adhesion molecule-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha - and interleukin-1-stimulated intercellular_adhesion_molecule-1 expression by murine renal tubular epithelial cells is transcriptionally regulated and involves protein kinase C .
2113475	0	Tumor_necrosis_factor-alpha	0,27	interferon-gamma	48,64	Tumor necrosis factor-alpha	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Tumor_necrosis_factor-alpha in combination with interferon-gamma , but not with interleukin_4 activates murine macrophages for elimination of Leishmania_major amastigotes .
7489766	0	Tumor_necrosis_factor-alpha	0,27	interferon-gamma	118,134	Tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	induction|amod|START_ENTITY inhibited|nsubjpass|induction inhibited|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induction of major histocompatibility complex class II antigen expression is inhibited by interferon-gamma in a monocytic cell line .
11577995	0	Tumor_necrosis_factor-alpha	0,27	interleukin-10	28,42	Tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	START_ENTITY|dep|balance balance|amod|END_ENTITY	Tumor_necrosis_factor-alpha / interleukin-10 balance in normal and cystic_fibrosis children .
8331299	0	Tumor_necrosis_factor-alpha	0,27	interleukin-1_alpha	36,55	Tumor necrosis factor-alpha	interleukin-1 alpha	7124	3552	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-1_alpha and interleukin-1 receptor antagonist production by cultured human keratinocytes .
2154976	0	Tumor_necrosis_factor-alpha	0,27	interleukin-1_beta	59,77	Tumor necrosis factor-alpha	interleukin-1 beta	7124	3553	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effects effects|nmod|steroidogenesis steroidogenesis|amod|END_ENTITY	Tumor_necrosis_factor-alpha enhances inhibitory effects of interleukin-1_beta on Leydig cell steroidogenesis .
2542010	0	Tumor_necrosis_factor-alpha	0,27	interleukin-1_beta	73,91	Tumor necrosis factor-alpha	interleukin-1 beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	secretagogue|nsubj|START_ENTITY secretagogue|dep|comparison comparison|nmod|END_ENTITY	Tumor_necrosis_factor-alpha is a potent ACTH secretagogue : comparison to interleukin-1_beta .
8604710	0	Tumor_necrosis_factor-alpha	0,27	interleukin-1_beta	29,47	Tumor necrosis factor-alpha	interleukin-1 beta	7124	3553	Gene	Gene	antagonist|advmod|START_ENTITY antagonist|nsubj|receptor receptor|amod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-1_beta , and interleukin-1 receptor antagonist in dialysate and serum from patients on continuous ambulatory peritoneal dialysis .
8608789	0	Tumor_necrosis_factor-alpha	0,27	interleukin-1_beta	37,55	Tumor necrosis factor-alpha	interleukin-1 beta	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|xcomp|END_ENTITY	Tumor_necrosis_factor-alpha prevents interleukin-1_beta from augmenting capsaicin-induced vasodilatation in the rat skin .
9377887	0	Tumor_necrosis_factor-alpha	0,27	interleukin-1_beta	29,47	Tumor necrosis factor-alpha	interleukin-1 beta	7124	3553	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-1_beta , and interleukin-6 concentrations in cerebrospinal fluid predict ventriculoperitoneal_shunt_infection .
10873159	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	70,83	Tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Tumor_necrosis_factor-alpha enhances mRNA expression and secretion of interleukin-6 in cultured human airway smooth muscle cells .
12889600	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	36,49	Tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-6 production via extracellular-regulated kinase 1 activation in breast_cancer cells .
15474068	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	51,64	Tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	induced|nsubj|START_ENTITY induced|dobj|release release|nmod|pathways pathways|amod|END_ENTITY	Tumor_necrosis_factor-alpha induced the release of interleukin-6 from endometriotic stromal cells by the nuclear_factor-kappaB and mitogen-activated protein kinase pathways .
23790133	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	29,42	Tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-10 levels are altered in preeclampsia : a systematic review and meta-analysis .
9089655	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	36,49	Tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|mRNA mRNA|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-6 mRNA and protein in human granulosa luteinizing cells via protein_tyrosine_kinase without involving ceramide .
9312119	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	42,55	Tumor necrosis factor-alpha	interleukin-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	autoregulates|nsubj|START_ENTITY autoregulates|dobj|synthesis synthesis|amod|END_ENTITY	Tumor_necrosis_factor-alpha autoregulates interleukin-6 synthesis via activation of protein_kinase_C .
9516459	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	36,49	Tumor necrosis factor-alpha	interleukin-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-6 production and integrin ligand expression by distinct transduction pathways .
9607836	0	Tumor_necrosis_factor-alpha	0,27	interleukin-6	29,42	Tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	START_ENTITY|appos|secretion secretion|amod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-8 secretion and the acute-phase response in patients with bacterial_and_tuberculous_osteomyelitis .
10690897	0	Tumor_necrosis_factor-alpha	0,27	interleukin-8	94,107	Tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inducing inducing|dobj|gene gene|amod|END_ENTITY	Tumor_necrosis_factor-alpha promotes proliferation of endometriotic stromal cells by inducing interleukin-8 gene and protein expression .
17003486	0	Tumor_necrosis_factor-alpha	0,27	interleukin-8	59,72	Tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells : implications for the genesis of chorioamnionitis .
10385397	0	Tumor_necrosis_factor-alpha	0,27	lactate_dehydrogenase_A	39,62	Tumor necrosis factor-alpha	lactate dehydrogenase A	7124	3939	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Tumor_necrosis_factor-alpha stimulates lactate_dehydrogenase_A expression in porcine cultured sertoli cells : mechanisms of action .
10891886	0	Tumor_necrosis_factor-alpha	0,27	leptin	83,89	Tumor necrosis factor-alpha	leptin	7124	3952	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|nmod|cytokine cytokine|appos|END_ENTITY	Tumor_necrosis_factor-alpha regulates secretion of the adipocyte-derived cytokine , leptin .
9538268	0	Tumor_necrosis_factor-alpha	0,27	macrophage_migration_inhibitory_factor	61,99	Tumor necrosis factor-alpha	macrophage migration inhibitory factor	7124	4282	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha regulates the gene expression of macrophage_migration_inhibitory_factor through tyrosine kinase-dependent pathway in 3T3-L1 adipocytes .
10030839	0	Tumor_necrosis_factor-alpha	0,27	mucin	39,44	Tumor necrosis factor-alpha	mucin	100135630(Tax:10141)	100508689	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	Tumor_necrosis_factor-alpha stimulates mucin secretion and cyclic_GMP production by guinea_pig tracheal epithelial cells in vitro .
18507686	0	Tumor_necrosis_factor-alpha	0,27	mucus_core_protein-2	63,83	Tumor necrosis factor-alpha	mucus core protein-2	24835(Tax:10116)	24572(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces the aberrant expression of mucus_core_protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic_cholangitis .
14994384	0	Tumor_necrosis_factor-alpha	0,27	osteoprotegerin	55,70	Tumor necrosis factor-alpha	osteoprotegerin	7124	4982	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha promotes the expression of osteoprotegerin in rheumatoid synovial fibroblasts .
16029216	0	Tumor_necrosis_factor-alpha	0,27	p55	40,43	Tumor necrosis factor-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY knockout|compound|receptor knockout|appos|END_ENTITY	Tumor_necrosis_factor-alpha receptor 1 -LRB- p55 -RRB- knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons .
7520777	0	Tumor_necrosis_factor-alpha	0,27	p55	224,227	Tumor necrosis factor-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|dep|role role|nmod|receptors receptors|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem_cell_factor and interleukin-7 : novel stimulatory role of p55 TNF receptors .
14656714	0	Tumor_necrosis_factor-alpha	0,27	peroxisome_proliferator-activated_receptor_gamma	37,85	Tumor necrosis factor-alpha	peroxisome proliferator-activated receptor gamma	7124	5468	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Tumor_necrosis_factor-alpha inhibits peroxisome_proliferator-activated_receptor_gamma activity at a posttranslational level in hepatic stellate cells .
19321447	0	Tumor_necrosis_factor-alpha	0,27	peroxisome_proliferator-activated_receptor_gamma	65,113	Tumor necrosis factor-alpha	peroxisome proliferator-activated receptor gamma	7124	5468	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cleavage cleavage|nmod|END_ENTITY	Tumor_necrosis_factor-alpha induces caspase-mediated cleavage of peroxisome_proliferator-activated_receptor_gamma in adipocytes .
1846897	0	Tumor_necrosis_factor-alpha	0,27	phospholipase_A2	39,55	Tumor necrosis factor-alpha	phospholipase A2	7124	151056	Gene	Gene	priming|amod|START_ENTITY priming|nmod|activation activation|amod|END_ENTITY	Tumor_necrosis_factor-alpha priming of phospholipase_A2 activation in human neutrophils .
9048615	0	Tumor_necrosis_factor-alpha	0,27	plasminogen_activator_inhibitor-1	38,71	Tumor necrosis factor-alpha	plasminogen activator inhibitor-1	24835(Tax:10116)	24617(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Tumor_necrosis_factor-alpha regulates plasminogen_activator_inhibitor-1 in rat testicular peritubular cells .
14534369	0	Tumor_necrosis_factor-alpha	0,27	plasminogen_activator_inhibitor_type_1	54,92	Tumor necrosis factor-alpha	plasminogen activator inhibitor type 1	7124	5054	Gene	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	Tumor_necrosis_factor-alpha and troglitazone_regulate plasminogen_activator_inhibitor_type_1 production through extracellular_signal-regulated_kinase - and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells .
16254029	0	Tumor_necrosis_factor-alpha	0,27	prolactin	48,57	Tumor necrosis factor-alpha	prolactin	7124	5617	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Tumor_necrosis_factor-alpha activates the human prolactin gene promoter via nuclear factor-kappaB signaling .
14749357	0	Tumor_necrosis_factor-alpha	0,27	serum_amyloid_A3	36,52	Tumor necrosis factor-alpha	serum amyloid A3	21926(Tax:10090)	20210(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Tumor_necrosis_factor-alpha induces serum_amyloid_A3 in mouse granulosa cells .
17719579	0	Tumor_necrosis_factor-alpha	0,27	sphingosine_kinase	78,96	Tumor necrosis factor-alpha	sphingosine kinase	7124	8877	Gene	Gene	action|amod|START_ENTITY action|nmod|myoblasts myoblasts|nmod|END_ENTITY	Tumor_necrosis_factor-alpha exerts pro-myogenic action in C2C12 myoblasts via sphingosine_kinase / S1P2 signaling .
15653932	0	Tumor_necrosis_factor-alpha	0,27	transforming_growth_factor-beta1	36,68	Tumor necrosis factor-alpha	transforming growth factor-beta1	21926(Tax:10090)	21803(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces transforming_growth_factor-beta1 expression in lung fibroblasts through the extracellular_signal-regulated_kinase pathway .
20128678	0	Tumor_necrosis_factor-alpha	0,27	transforming_growth_factor-beta1	148,180	Tumor necrosis factor-alpha	transforming growth factor-beta1	7124	7040	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|transition transition|acl|induced induced|advcl|END_ENTITY	Tumor_necrosis_factor-alpha enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming_growth_factor-beta1 .
17084400	0	Tumor_necrosis_factor-alpha	0,27	vascular_endothelial_growth_factor	38,72	Tumor necrosis factor-alpha	vascular endothelial growth factor	7124	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Tumor_necrosis_factor-alpha regulates vascular_endothelial_growth_factor secretion by human oviductal epithelial cells and stromal fibroblasts .
21740086	0	Tumor_necrosis_factor-alpha	0,27	vascular_endothelial_growth_factor	62,96	Tumor necrosis factor-alpha	vascular endothelial growth factor	7124	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inducing inducing|dobj|END_ENTITY	Tumor_necrosis_factor-alpha promotes tumor growth by inducing vascular_endothelial_growth_factor .
17216674	0	Tumor_necrosis_factor-alpha	0,27	vascular_endothelial_growth_factor-C	36,72	Tumor necrosis factor-alpha	vascular endothelial growth factor-C	7124	7424	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha induces vascular_endothelial_growth_factor-C expression in rheumatoid synoviocytes .
9705358	0	Tumor_necrosis_factor-alpha	0,27	vascular_endothelial_growth_factor_receptor-2	52,97	Tumor necrosis factor-alpha	vascular endothelial growth factor receptor-2	7124	3791	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Tumor_necrosis_factor-alpha regulates expression of vascular_endothelial_growth_factor_receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells .
18296613	0	Tumor_necrosis_factor-alpha-converting_enzyme	0,45	TACE	47,51	Tumor necrosis factor-alpha-converting enzyme	TACE	6868	6868	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Tumor_necrosis_factor-alpha-converting_enzyme -LRB- TACE -RRB- levels in periodontal_diseases .
12441351	0	Tumor_necrosis_factor-alpha_converting_enzyme	0,45	ADAM_17	46,53	Tumor necrosis factor-alpha converting enzyme	ADAM 17	6868	6868	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha_converting_enzyme / ADAM_17 mediates MUC1 shedding .
26792723	0	Tumor_necrosis_factor-related_apoptosis-inducing_ligand	0,55	sigma_1_receptor	122,138	Tumor necrosis factor-related apoptosis-inducing ligand	sigma 1 receptor	8743	10280	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- activates caspases in human prostate_cancer cells through sigma_1_receptor .
22922291	0	Tumor_necrosis_factor_a	0,23	caspase-8	63,72	Tumor necrosis factor a	caspase-8	7124	841	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	Tumor_necrosis_factor_a stimulates Her-2 cleavage by activated caspase-8 .
17335569	0	Tumor_necrosis_factor_alpha	0,27	CD36	67,71	Tumor necrosis factor alpha	CD36	7124	948	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor_alpha and adalimumab differentially regulate CD36 expression in human monocytes .
20564184	0	Tumor_necrosis_factor_alpha	0,27	ERK1/2	59,65	Tumor necrosis factor alpha	ERK1/2	7124	5595;5594	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nummod|END_ENTITY	Tumor_necrosis_factor_alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells .
11179369	0	Tumor_necrosis_factor_alpha	0,27	Gb3	70,73	Tumor necrosis factor alpha	Gb3	7124	53947	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Tumor_necrosis_factor_alpha increases human cerebral endothelial cell Gb3 and sensitivity to Shiga toxin .
8906209	0	Tumor_necrosis_factor_alpha	0,27	ICAM-1	48,54	Tumor necrosis factor alpha	ICAM-1	7124	3383	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- - induced ICAM-1 surface expression in airway epithelial cells in vitro : possible signal transduction mechanisms .
10887174	1	Tumor_necrosis_factor_alpha	58,85	K6b	94,97	Tumor necrosis factor alpha	K6b	7124	3854	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	Tumor_necrosis_factor_alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappa_B and C/EBPbeta .
20564184	0	Tumor_necrosis_factor_alpha	0,27	LIF	36,39	Tumor necrosis factor alpha	LIF	7124	3976	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Tumor_necrosis_factor_alpha induces LIF expression through ERK1/2 activation in mammary epithelial cells .
15142990	0	Tumor_necrosis_factor_alpha	0,27	MUC1	39,43	Tumor necrosis factor alpha	MUC1	7124	4582	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|synthesis synthesis|compound|END_ENTITY	Tumor_necrosis_factor_alpha stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line .
11450703	0	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	141,150	Tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|HCS-2 HCS-2|dep|cells cells|nmod|END_ENTITY	Tumor_necrosis_factor_alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2 / 8 cells through activation of NF-kappaB : abrogation of the tumor_necrosis_factor_alpha effect by proteasome inhibitors .
12663241	0	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	94,103	Tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	START_ENTITY|dep|expression expression|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
15485901	0	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	41,50	Tumor necrosis factor alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Tumor_necrosis_factor_alpha induction of NF-kappaB requires the novel coactivator SIMPL .
19854828	0	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	152,161	Tumor necrosis factor alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|protein protein|acl|signaling signaling|advcl|interfering interfering|nmod|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor_alpha represses bone morphogenetic protein -LRB- BMP -RRB- signaling by interfering with the DNA binding of Smads through the activation of NF-kappaB .
8939978	0	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	85,94	Tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|advmod|early early|nmod|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor_alpha induces the adenovirus early 3 promoter by activation of NF-kappaB .
9099747	0	Tumor_necrosis_factor_alpha	0,27	NF-kappaB	38,47	Tumor necrosis factor alpha	NF-kappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|fibroblasts fibroblasts|amod|END_ENTITY	Tumor_necrosis_factor_alpha activates NF-kappaB in acid_sphingomyelinase-deficient mouse embryonic fibroblasts .
8413329	0	Tumor_necrosis_factor_alpha	0,27	NF-kappa_B	107,117	Tumor necrosis factor alpha	NF-kappa B	7124	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Tumor_necrosis_factor_alpha mediates a T cell receptor-independent induction of the gene regulatory factor NF-kappa_B in T lymphocytes .
12663241	0	Tumor_necrosis_factor_alpha	0,27	RANTES	48,54	Tumor necrosis factor alpha	RANTES	7124	6352	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
15647276	0	Tumor_necrosis_factor_alpha	0,27	Rac1	43,47	Tumor necrosis factor alpha	Rac1	21926(Tax:10090)	19353(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Tumor_necrosis_factor_alpha stimulation of Rac1 activity .
18996094	0	Tumor_necrosis_factor_alpha	0,27	Sp1	119,122	Tumor necrosis factor alpha	Sp1	7124	6667	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Tumor_necrosis_factor_alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1 .
12663241	0	Tumor_necrosis_factor_alpha	0,27	TNF-alpha	133,142	Tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	START_ENTITY|dep|roles roles|nmod|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- - induced RANTES chemokine expression via activation of NF-kappaB and p38 MAP kinase : roles of TNF-alpha in alcoholic_liver_diseases .
8359919	0	Tumor_necrosis_factor_alpha	0,27	TNF-alpha	29,38	Tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- production in mice immunized with Escherichia_coli : correlation with mortality after lethal challenge and production of a native inhibitor of TNF-alpha activity .
10614649	0	Tumor_necrosis_factor_alpha	0,27	beta5	46,51	Tumor necrosis factor alpha	beta5	21926(Tax:10090)	16419(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor_alpha regulates alpha -LRB- v -RRB- beta5 integrin expression by osteoclast precursors in vitro and in vivo .
7522632	0	Tumor_necrosis_factor_alpha	0,27	c-kit	54,59	Tumor necrosis factor alpha	c-kit	7124	3815	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
2359342	0	Tumor_necrosis_factor_alpha	0,27	c-myc	43,48	Tumor necrosis factor alpha	c-myc	7124	4609	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor_alpha down-regulates c-myc mRNA expression and induces in vitro monocytic differentiation in fresh blast cells from patients with acute_myeloblastic_leukemia .
3282023	0	Tumor_necrosis_factor_alpha	0,27	cachectin	28,37	Tumor necrosis factor alpha	cachectin	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|factor factor|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha / cachectin is a growth factor for thymocytes .
22562303	0	Tumor_necrosis_factor_alpha	0,27	cathepsin_K	39,50	Tumor necrosis factor alpha	cathepsin K	7124	1513	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|compound|END_ENTITY	Tumor_necrosis_factor_alpha stimulates cathepsin_K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation .
11505407	0	Tumor_necrosis_factor_alpha	0,27	epithelial_cell_adhesion_molecule	100,133	Tumor necrosis factor alpha	epithelial cell adhesion molecule	7124	4072	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor_alpha negatively regulates the expression of the carcinoma-associated antigen epithelial_cell_adhesion_molecule .
20178529	0	Tumor_necrosis_factor_alpha	0,27	interleukin-6	29,42	Tumor necrosis factor alpha	interleukin-6	7124	3569	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	Tumor_necrosis_factor_alpha , interleukin-6 and interleukin-10 polymorphisms in preeclampsia .
7684436	0	Tumor_necrosis_factor_alpha	0,27	interleukin_3	44,57	Tumor necrosis factor alpha	interleukin 3	7124	3562	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Tumor_necrosis_factor_alpha cooperates with interleukin_3 in the recruitment of a primitive subset of human CD34 + progenitors .
8313662	0	Tumor_necrosis_factor_alpha	0,27	leukemia_inhibitory_factor	53,79	Tumor necrosis factor alpha	leukemia inhibitory factor	7124	3976	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Tumor_necrosis_factor_alpha stimulates production of leukemia_inhibitory_factor in human dermal fibroblast cultures .
16757480	0	Tumor_necrosis_factor_alpha	0,27	nuclear_factor_kappaB	85,106	Tumor necrosis factor alpha	nuclear factor kappaB	7124	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Tumor_necrosis_factor_alpha induces spermidine/spermine N1-acetyltransferase through nuclear_factor_kappaB in non-small_cell_lung_cancer cells .
20173470	0	Tumor_necrosis_factor_alpha	0,27	p53	36,39	Tumor necrosis factor alpha	p53	7124	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|modulator modulator|compound|END_ENTITY	Tumor_necrosis_factor_alpha induces p53 up-regulated modulator of apoptosis expression in colorectal_cancer cell lines .
1310016	0	Tumor_necrosis_factor_alpha	0,27	parathyroid_hormone-related_protein	67,102	Tumor necrosis factor alpha	parathyroid hormone-related protein	7124	5744	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|effect effect|nmod|END_ENTITY	Tumor_necrosis_factor_alpha inhibits the stimulatory effect of the parathyroid_hormone-related_protein on cyclic_AMP formation in osteoblast-like cells via protein kinase C + .
11689013	0	Tumor_necrosis_factor_alpha	0,27	resistin	55,63	Tumor necrosis factor alpha	resistin	7124	56729	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Tumor_necrosis_factor_alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes .
26723579	0	Tumor_necrosis_factor_alpha	0,27	semaphorin_3B	88,101	Tumor necrosis factor alpha	semaphorin 3B	7124	7869	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|END_ENTITY	Tumor_necrosis_factor_alpha suppresses osteogenic differentiation of MSCs by inhibiting semaphorin_3B via Wnt/b-catenin signaling in estrogen-deficiency induced osteoporosis .
8430098	0	Tumor_necrosis_factor_alpha	0,27	transforming_growth_factor_alpha	54,86	Tumor necrosis factor alpha	transforming growth factor alpha	7124	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Tumor_necrosis_factor_alpha induces the expression of transforming_growth_factor_alpha and the epidermal_growth_factor_receptor in human pancreatic_cancer cells .
7537041	0	Tumor_necrosis_factor_alpha	0,27	vascular_cell_adhesion_molecule-1	83,116	Tumor necrosis factor alpha	vascular cell adhesion molecule-1	21926(Tax:10090)	22329(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor_alpha and interleukin-1_beta but not interferon_gamma induce vascular_cell_adhesion_molecule-1 expression on primary cultured murine hepatocytes .
12972643	0	Tumor_necrosis_factor_alpha-converting_enzyme	0,45	MUC5AC	55,61	Tumor necrosis factor alpha-converting enzyme	MUC5AC	6868	4586	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Tumor_necrosis_factor_alpha-converting_enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells .
24696164	0	Tumor_necrosis_factor_beta	0,26	HLA-DRB1	153,161	Tumor necrosis factor beta	HLA-DRB1	4049	3123	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Tumor_necrosis_factor_beta -LRB- TNF-b -RRB- NcoI polymorphism is associated with multiple_sclerosis in Caucasian patients from Southern Brazil independently from HLA-DRB1 .
24696164	0	Tumor_necrosis_factor_beta	0,26	TNF-b	28,33	Tumor necrosis factor beta	TNF-b	4049	4049	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Tumor_necrosis_factor_beta -LRB- TNF-b -RRB- NcoI polymorphism is associated with multiple_sclerosis in Caucasian patients from Southern Brazil independently from HLA-DRB1 .
12958312	0	Tumor_necrosis_factor_receptor-associated_factor_2	0,50	CD40	115,119	Tumor necrosis factor receptor-associated factor 2	CD40	22030(Tax:10090)	21939(Tax:10090)	Gene	Gene	START_ENTITY|dep|deficient deficient|acl:relcl|reveal reveal|nmod|TRAF2 TRAF2|nmod|signaling signaling|compound|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- - deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling .
9432981	0	Tumor_necrosis_factor_receptor-associated_factor_6	0,50	CD40	126,130	Tumor necrosis factor receptor-associated factor 6	CD40	7189	958	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
9432981	0	Tumor_necrosis_factor_receptor-associated_factor_6	0,50	extracellular_signal-regulated_kinase	70,107	Tumor necrosis factor receptor-associated factor 6	extracellular signal-regulated kinase	7189	5594	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
21454471	0	Tumor_necrosis_factor_receptor-associated_factor_6	0,50	huntingtin	75,85	Tumor necrosis factor receptor-associated factor 6	huntingtin	22034(Tax:10090)	3064	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation .
16020544	0	Tumor_necrosis_factor_receptor_2	0,32	TNFR2	34,39	Tumor necrosis factor receptor 2	TNFR2	7133	7133	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- signaling is negatively regulated by a novel , carboxyl-terminal TNFR-associated_factor_2 -LRB- TRAF2 -RRB- - binding site .
11357933	0	Tumor_necrosis_factor_receptor_2	0,32	TNFRSF1B	39,47	Tumor necrosis factor receptor 2	TNFRSF1B	7133	7133	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tumor_necrosis_factor_receptor_2 gene -LRB- TNFRSF1B -RRB- in genetic basis of coronary_artery_disease .
23080298	0	Tumor_progression_locus_2	0,25	Cot	26,29	Tumor progression locus 2	Cot	26410(Tax:10090)	26410(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|END_ENTITY	Tumor_progression_locus_2 / Cot is required for activation of extracellular regulated kinase in liver_injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic stellate cells in mice .
24067374	0	Tumor_protein_translationally_controlled_1	0,42	p53	48,51	Tumor protein translationally controlled 1	p53	22070(Tax:10090)	22060(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Tumor_protein_translationally_controlled_1 is a p53 target gene that promotes cell survival .
10373639	0	Tumor_suppressor	0,16	CDKN2A	27,33	Tumor suppressor	CDKN2A	7248	1029	Gene	Gene	p16|amod|START_ENTITY p16|appos|END_ENTITY	Tumor_suppressor gene p16 -LRB- CDKN2A -RRB- mutation status and promoter inactivation in head_and_neck_cancer .
11340094	0	Tumor_suppressor	0,16	p53	25,28	Tumor suppressor	p53	7248	7157	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Tumor_suppressor protein p53 mRNA and subcellular localization are altered by changes in cellular copper in human Hep G2 cells .
22033922	0	Tumor_suppressor	0,16	p53	55,58	Tumor suppressor	p53	7248	7157	Gene	Gene	Pdcd4|amod|START_ENTITY inhibits|nsubj|Pdcd4 inhibits|dobj|translation translation|nmod|mRNA mRNA|compound|END_ENTITY	Tumor_suppressor protein Pdcd4 inhibits translation of p53 mRNA .
7603913	0	Tumor_suppressor	0,16	p53	22,25	Tumor suppressor	p53	7248	7157	Gene	Gene	START_ENTITY|dobj|mutations mutations|compound|END_ENTITY	Tumor_suppressor gene p53 mutations in human prostate_cancer .
7981075	0	Tumour-associated_trypsin_inhibitor	0,35	CA125	60,65	Tumour-associated trypsin inhibitor	CA125	6690	94025	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Tumour-associated_trypsin_inhibitor -LRB- TATI -RRB- : comparison with CA125 as a preoperative prognostic indicator in advanced ovarian_cancer .
1381227	0	Tumour_necrosis_factor	0,22	ELAM-1	36,42	Tumour necrosis factor	ELAM-1	7124	6401	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Tumour_necrosis_factor induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells -- analysis of tumour_necrosis_factor-receptor interactions .
16207331	0	Tumour_necrosis_factor	0,22	p38alpha	71,79	Tumour necrosis factor	p38alpha	7124	1432	Gene	Gene	activates|nsubj|START_ENTITY activates|ccomp|kinases kinases|dobj|END_ENTITY	Tumour_necrosis_factor activates the mitogen-activated protein kinases p38alpha and ERK in the synovial membrane in vivo .
3128274	0	Tumour_necrosis_factor	0,22	phospholipase_A2	43,59	Tumour necrosis factor	phospholipase A2	280943(Tax:9913)	104974671	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	Tumour_necrosis_factor -LRB- cachectin -RRB- induces phospholipase_A2 activity and synthesis of a phospholipase_A2-activating protein in endothelial cells .
23293927	0	Tumour_necrosis_factor_a	0,24	CCL2	34,38	Tumour necrosis factor a	CCL2	7124	6347	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Tumour_necrosis_factor_a enhances CCL2 and ICAM-1 expression in peripheral nerve microvascular endoneurial endothelial cells .
25158810	0	Tumour_necrosis_factor_receptor-associated_factor-1	0,51	TRAF-1	53,59	Tumour necrosis factor receptor-associated factor-1	TRAF-1	7185	7185	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tumour_necrosis_factor_receptor-associated_factor-1 -LRB- TRAF-1 -RRB- expression is increased in renal_cell_carcinoma patient serum but decreased in cancer tissue compared with normal : potential biomarker significance .
12731667	0	Tunica_interna_endothelial_cell_kinase	0,38	CD34	108,112	Tunica interna endothelial cell kinase	CD34	7010	947	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Tunica_interna_endothelial_cell_kinase expression and hematopoietic and angiogenic potentials in cord blood CD34 + cells .
8943325	0	Tup1	16,20	Cyc8	4,8	Tup1	Cyc8	850445(Tax:4932)	852410(Tax:4932)	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	The Cyc8 -LRB- Ssn6 -RRB- - Tup1 corepressor complex is composed of one Cyc8 and four Tup1 subunits .
11118219	0	Tup1p	48,53	Srb7p	0,5	Tup1p	Srb7p	850445(Tax:4932)	851903(Tax:4932)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Srb7p is a physical and physiological target of Tup1p .
10329666	0	Tvl-1	46,51	Raf-1	90,95	Tvl-1	Raf-1	19727(Tax:10090)	110157(Tax:10090)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1 .
16571634	0	Twinstar	0,8	cofilin/ADF	36,47	Twinstar	cofilin/ADF	37841(Tax:7227)	37841(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Twinstar , the Drosophila homolog of cofilin/ADF , is required for planar cell polarity patterning .
20025748	0	Twist	16,21	E-cadherin	58,68	Twist	E-cadherin	7291	999	Gene	Gene	expression|compound|START_ENTITY Significance|nmod|expression Significance|nmod|END_ENTITY	Significance of Twist expression and its association with E-cadherin in esophageal_squamous_cell_carcinoma .
19345188	0	Twist-1	0,7	PGC-1alpha	65,75	Twist-1	PGC-1alpha	22160(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Twist-1 is a PPARdelta-inducible , negative-feedback regulator of PGC-1alpha in brown fat metabolism .
21866569	0	Twist1	48,54	ATF4	79,83	Twist1	ATF4	7291	468	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts .
24491388	0	Twist1	60,66	CLU	37,40	Twist1	CLU	22160(Tax:10090)	12759(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Insulin-like growth factor-I induces CLU expression through Twist1 to promote prostate_cancer growth .
25446074	0	Twist1	81,87	DEC2	55,59	Twist1	DEC2	22160(Tax:10090)	79362(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The basic helix-loop-helix -LRB- bHLH -RRB- transcription factor DEC2 negatively regulates Twist1 through an E-box element .
22685315	0	Twist1	0,6	Ifng	17,21	Twist1	Ifng	7291	3458	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function .
20727876	0	Twist1	32,38	Jagged1	0,7	Twist1	Jagged1	7291	182	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells .
25704764	0	Twist1	100,106	Sox12	0,5	Twist1	Sox12	7291	6666	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Sox12 , a direct target of FoxQ1 , promotes hepatocellular_carcinoma metastasis through up-regulating Twist1 and FGFBP1 .
22532563	0	Twist1	44,50	Sox9	117,121	Twist1	Sox9	7291	6662	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|nmod|END_ENTITY	Basic helix-loop-helix transcription factor Twist1 inhibits transactivator function of master chondrogenic regulator Sox9 .
26582088	0	Twist1	59,65	TLR4	0,4	Twist1	TLR4	22160(Tax:10090)	21898(Tax:10090)	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|compound|END_ENTITY	TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice .
25486906	0	Twist1	27,33	miR-148a	0,8	Twist1	miR-148a	22160(Tax:10090)	387166(Tax:10090)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim .
25867064	0	Twist1	22,28	miR-186	0,7	Twist1	miR-186	7291	406962	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	miR-186 regulation of Twist1 and ovarian_cancer sensitivity to cisplatin .
23864307	0	Twist1	35,41	miR-675	0,7	Twist1	miR-675	7291	100033819	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	miR-675 mediates downregulation of Twist1 and Rb in AFP-secreting hepatocellular_carcinoma .
20689556	0	Twist1	30,36	p53	7,10	Twist1	p53	7291	7157	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Mutant p53 -LRB- R175H -RRB- upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells .
24927592	0	Twist1	79,85	p62	50,53	Twist1	p62	22160(Tax:10090)	18226(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cell proliferation and migration by p62 through stabilization of Twist1 .
23946798	0	Twist2	0,6	Akt	67,70	Twist2	Akt	117581	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Twist2 promotes ovarian_cancer cell survival through activation of Akt .
24193512	0	Twist2	0,6	CD24	75,79	Twist2	CD24	117581	100133941	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Twist2 promotes self-renewal of liver_cancer stem-like cells by regulating CD24 .
19937140	0	Twist2	0,6	CD7	17,20	Twist2	CD7	117581	924	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells .
21705327	0	Txnip	76,81	Thioredoxin	0,11	Txnip	Thioredoxin	10628	7295	Gene	Gene	thioredoxin-interacting_protein|dep|START_ENTITY stability|amod|thioredoxin-interacting_protein regulates|nmod|stability regulates|nsubj|END_ENTITY	Thioredoxin regulates adipogenesis through thioredoxin-interacting_protein -LRB- Txnip -RRB- protein stability .
20558747	0	Txnip	33,38	Thioredoxin-interacting_protein	0,31	Txnip	Thioredoxin-interacting protein	10628	10628	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Thioredoxin-interacting_protein -LRB- Txnip -RRB- gene expression : sensing oxidative phosphorylation status and glycolytic rate .
16766796	0	Txnip	36,41	thioredoxin	19,30	Txnip	thioredoxin	10628	7295	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of thioredoxin with Txnip .
19254690	0	Txnip	50,55	thioredoxin	107,118	Txnip	thioredoxin	10628	7295	Gene	Gene	thioredoxin_interacting_protein|appos|START_ENTITY Up-regulation|nmod|thioredoxin_interacting_protein contributes|nsubj|Up-regulation contributes|nmod|activity activity|compound|END_ENTITY	Up-regulation of thioredoxin_interacting_protein -LRB- Txnip -RRB- by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells .
23715727	0	Txnip	44,49	thioredoxin-interacting_protein	11,42	Txnip	thioredoxin-interacting protein	56338(Tax:10090)	56338(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for thioredoxin-interacting_protein -LRB- Txnip -RRB- in cellular creatine homeostasis .
7629131	0	Tyk-2	56,61	hematopoietic_cell_phosphatase	71,101	Tyk-2	hematopoietic cell phosphatase	7297	5777	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic_cell_phosphatase .
12554654	0	Tyk2	20,24	IFNAR1	34,40	Tyk2	IFNAR1	7297	3454	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|nummod|END_ENTITY	The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression .
16751369	0	Tyk2	0,4	IL-10	111,116	Tyk2	IL-10	54721(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|mediating mediating|advcl|signaling signaling|dobj|reactivation reactivation|compound|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
16751369	0	Tyk2	0,4	IL-10	61,66	Tyk2	IL-10	54721(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|mediating mediating|dobj|END_ENTITY	Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation .
7589510	0	Tyk2	66,70	Thrombopoietin	0,14	Tyk2	Thrombopoietin	7297	7066	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombopoietin , c-Mpl_ligand , induces tyrosine phosphorylation of Tyk2 , JAK2 , and STAT3 , and enhances agonists-induced aggregation in platelets in vitro .
7867073	0	Tyro_3	81,87	Axl	88,91	Tyro 3	Axl	7301	558	Gene	Gene	family|amod|START_ENTITY family|compound|END_ENTITY	The anticoagulation factor protein S and its relative , Gas6 , are ligands for the Tyro_3 / Axl family of receptor tyrosine kinases .
15956026	0	Tyro_3	20,26	Tyro_3	45,51	Tyro 3	Tyro 3	7301	7301	Gene	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Immunoexpression of Tyro_3 family receptors -- Tyro_3 , Axl , and Mer -- and their ligand Gas6 in postnatal developing mouse testis .
15956026	0	Tyro_3	45,51	Tyro_3	20,26	Tyro 3	Tyro 3	7301	7301	Gene	Gene	receptors|dep|START_ENTITY receptors|amod|END_ENTITY	Immunoexpression of Tyro_3 family receptors -- Tyro_3 , Axl , and Mer -- and their ligand Gas6 in postnatal developing mouse testis .
20447099	0	Tyrosinase	0,10	TYR	17,20	Tyrosinase	TYR	7299	7299	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tyrosinase gene -LRB- TYR -RRB- mutations in Chinese patients with oculocutaneous_albinism_type_1 .
2172391	0	Tyrosinase	0,10	alpha-melanocyte-stimulating_hormone	64,100	Tyrosinase	alpha-melanocyte-stimulating hormone	7299	5443	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Tyrosinase synthesis in different skin types and the effects of alpha-melanocyte-stimulating_hormone and cyclic_AMP .
13680365	0	Tyrosinase	0,10	oculocutaneous_albinism_1	29,54	Tyrosinase	oculocutaneous albinism 1	7299	7299	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Tyrosinase gene mutations in oculocutaneous_albinism_1 -LRB- OCA1 -RRB- : definition of the phenotype .
11851885	0	Tyrosinase	0,10	p53	43,46	Tyrosinase	p53	7299	7157	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Tyrosinase gene expression is regulated by p53 .
26975317	0	Tyrosine_Hydroxylase	14,34	Prion_Protein	63,76	Tyrosine Hydroxylase	Prion Protein	7054	5621	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of Tyrosine_Hydroxylase is Negatively Regulated Via Prion_Protein .
24594844	0	Tyrosine_Kinase	28,43	EGFR	11,15	Tyrosine Kinase	EGFR	7294	1956	Gene	Gene	Inhibitor|compound|START_ENTITY Inhibitor|compound|END_ENTITY	Overcoming EGFR T790M-based Tyrosine_Kinase Inhibitor Resistance with an Allele-specific DNAzyme .
24785348	0	Tyrosine_Kinase	57,72	VEGFR2	41,47	Tyrosine Kinase	VEGFR2	30256(Tax:7955)	796537(Tax:7955)	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine_Kinase Regulates Endothelial Function and Blood Vessel Formation .
26058065	0	Tyrosine_Kinase	64,79	c-Src	92,97	Tyrosine Kinase	c-Src	7294	6714	Gene	Gene	Activity|amod|START_ENTITY Activity|nmod|END_ENTITY	Ca2 + / Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine_Kinase Activity of c-Src .
25763473	0	Tyrosine_Threonine_Kinase	37,62	TTK	64,67	Tyrosine Threonine Kinase	TTK	7272	7272	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	The Discovery of Orally Bioavailable Tyrosine_Threonine_Kinase -LRB- TTK -RRB- Inhibitors : 3 - -LRB- 4 - -LRB- heterocyclyl -RRB- phenyl -RRB- -1 H-indazole-5-carboxamides as Anticancer Agents .
2896626	0	Tyrosine_aminotransferase	0,25	haptoglobin	63,74	Tyrosine aminotransferase	haptoglobin	6898	3240	Gene	Gene	linked|nsubjpass|START_ENTITY linked|xcomp|END_ENTITY	Tyrosine_aminotransferase and chymotrypsinogen_B are linked to haptoglobin on human chromosome 16q : comparison of genetic and physical distances .
23722874	0	Tyrosine_hydroxylase	0,20	CD4	35,38	Tyrosine hydroxylase	CD4	21823(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Tyrosine_hydroxylase expression in CD4 -LRB- + -RRB- T cells is associated with joint inflammatory alleviation in collagen_type_II-induced_arthritis .
17229652	0	Tyrosine_kinase	0,15	JAK2	29,33	Tyrosine kinase	JAK2	7294	3717	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Tyrosine_kinase mutations of JAK2 are rare events in AML but influence prognosis of patients with CBF-leukemias .
19124464	0	Tyrosine_kinase	0,15	epidermal_growth_factor_receptor	28,60	Tyrosine kinase	epidermal growth factor receptor	7294	1956	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine_kinase activity of epidermal_growth_factor_receptor is regulated by GM3 binding through carbohydrate to carbohydrate interactions .
20713887	0	Tyrosine_kinase_2	0,17	IL-1	27,31	Tyrosine kinase 2	IL-1	54721(Tax:10090)	111343(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|production production|compound|END_ENTITY	Tyrosine_kinase_2 controls IL-1 production at the translational level .
20727854	0	Tyrosine_kinase_2	0,17	Siva-1	58,64	Tyrosine kinase 2	Siva-1	54721(Tax:10090)	30954(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tyrosine_kinase_2 interacts with the proapoptotic protein Siva-1 and augments its apoptotic functions .
25382057	0	Tyrosine_kinase_receptor_B	0,26	TrkB	28,32	Tyrosine kinase receptor B	TrkB	4915	4915	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tyrosine_kinase_receptor_B -LRB- TrkB -RRB- expression in colorectal_cancers highlights anoikis resistance as a survival mechanism of tumour budding cells .
1400466	0	Tyrosine_phosphatase	0,20	CD45	42,46	Tyrosine phosphatase	CD45	13924(Tax:10090)	19264(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tyrosine_phosphatase activity of lymphoma CD45 -LRB- GP180 -RRB- is regulated by a direct interaction with the cytoskeleton .
10644000	0	Tyrp1	34,39	tyrosinase_related_protein-1	4,32	Tyrp1	tyrosinase related protein-1	22178(Tax:10090)	22178(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	The tyrosinase_related_protein-1 -LRB- Tyrp1 -RRB- promoter in transgenic experiments : targeted expression to the retinal_pigment_epithelium .
23634227	0	Tzfp	0,4	androgen_receptor	19,36	Tzfp	androgen receptor	58206(Tax:10090)	11835(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	Tzfp represses the androgen_receptor in mouse testis .
16294307	0	U-87	147,151	PTEN	123,127	U-87	PTEN	641648	5728	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells .
12486009	0	U1-C	44,48	TIA-1	23,28	U1-C	TIA-1	6631	7072	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The splicing regulator TIA-1 interacts with U1-C to promote U1_snRNP recruitment to 5 ' splice sites .
18769035	0	U11	19,22	TNR-CFTR	54,62	U11	TNR-CFTR	26824	1080;7143	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Small nuclear RNAs U11 and U12 modulate expression of TNR-CFTR mRNA in mammalian kidneys .
26479860	0	U11	59,62	snRNP	63,68	U11	snRNP	26824	57819	Gene	Gene	mediate|compound|START_ENTITY mediate|compound|END_ENTITY	Evolutionarily conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11-48K and U11/U12 -65 K genes .
21298455	0	U1A	36,39	NS5	55,58	U1A	NS5	6626	5894	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow_fever_virus .
10068039	0	U1C	113,116	U1snRNP	94,101	U1C	U1snRNP	6631	55599	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein ; epitope mapping , immunolocalization and V-gene usage .
8595884	0	U1_snRNA	0,8	U6_snRNA	61,69	U1 snRNA	U6 snRNA	26871	26827	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	U1_snRNA promotes the selection of nearby 5 ' splice sites by U6_snRNA in mammalian cells .
18339208	0	U1_snRNA	78,86	chorionic_gonadotropin_beta_subunit	19,54	U1 snRNA	chorionic gonadotropin beta subunit	26871	1082	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduction of human chorionic_gonadotropin_beta_subunit expression by modified U1_snRNA caused apoptosis in cervical cancer cells .
24497193	0	U1_snRNP	57,65	Yhc1	35,39	U1 snRNP	Yhc1	26871	851005(Tax:4932)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Structure-function analysis of the Yhc1 subunit of yeast U1_snRNP and genetic interactions of Yhc1 with Mud2 , Nam8 , Mud1 , Tgs1 , U1 snRNA , SmD3 and Prp28 .
10068039	0	U1snRNP	94,101	U1C	113,116	U1snRNP	U1C	55599	6631	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Human monoclonal autoantibody fragments from combinatorial antibody libraries directed to the U1snRNP associated U1C protein ; epitope mapping , immunolocalization and V-gene usage .
9387929	0	U22	4,7	UHG	19,22	U22	UHG	9304	23642	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The U22 host gene -LRB- UHG -RRB- : chromosomal localization of UHG and distribution of U22 small nucleolar RNA .
18616943	0	U24	19,22	MBP	120,123	U24	MBP	26820	4155	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of U24 from Human_Herpes_Virus_type_6 -LRB- HHV-6 -RRB- and its potential role in mimicking myelin_basic_protein -LRB- MBP -RRB- in multiple_sclerosis .
7680770	0	U2AF	55,59	Sex-lethal	12,22	U2AF	Sex-lethal	33201(Tax:7227)	3772180(Tax:7227)	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA .
26508027	0	U2AF1	38,43	SF3B1	45,50	U2AF1	SF3B1	7307	23451	Gene	Gene	ASXL1|nummod|START_ENTITY ASXL1|nummod|END_ENTITY	Genetic landscape of recurrent ASXL1 , U2AF1 , SF3B1 , SRSF2 , and EZH2 mutations in 304 Chinese patients with myelodysplastic_syndromes .
26508027	0	U2AF1	38,43	SRSF2	52,57	U2AF1	SRSF2	7307	6427	Gene	Gene	ASXL1|nummod|START_ENTITY ASXL1|nummod|END_ENTITY	Genetic landscape of recurrent ASXL1 , U2AF1 , SF3B1 , SRSF2 , and EZH2 mutations in 304 Chinese patients with myelodysplastic_syndromes .
8660980	0	U2AF1	67,72	U2_snRNP_auxiliary_factor_small_35-kDa_subunit	19,65	U2AF1	U2 snRNP auxiliary factor small 35-kDa subunit	7307	7307	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The gene for human U2_snRNP_auxiliary_factor_small_35-kDa_subunit -LRB- U2AF1 -RRB- maps to the progressive myoclonus_epilepsy -LRB- EPM1 -RRB- critical region on chromosome 21q22 .3 .
9784496	0	U2AF65	39,45	WT1	0,3	U2AF65	WT1	11338	7490	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes .
8630064	0	U2AFBPL	25,32	U2afbp-rs	80,89	U2AFBPL	U2afbp-rs	7310	22183(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Absence of imprinting in U2AFBPL , a human homologue of the imprinted mouse gene U2afbp-rs .
8660980	0	U2_snRNP_auxiliary_factor_small_35-kDa_subunit	19,65	U2AF1	67,72	U2 snRNP auxiliary factor small 35-kDa subunit	U2AF1	7307	7307	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for human U2_snRNP_auxiliary_factor_small_35-kDa_subunit -LRB- U2AF1 -RRB- maps to the progressive myoclonus_epilepsy -LRB- EPM1 -RRB- critical region on chromosome 21q22 .3 .
7870588	0	U2af1-rs1	59,68	SP2	70,73	U2af1-rs1	SP2	22183(Tax:10090)	78912(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allele-specific methylation and expression of an imprinted U2af1-rs1 -LRB- SP2 -RRB- gene .
8630064	0	U2afbp-rs	80,89	U2AFBPL	25,32	U2afbp-rs	U2AFBPL	22183(Tax:10090)	7310	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Absence of imprinting in U2AFBPL , a human homologue of the imprinted mouse gene U2afbp-rs .
15840814	0	U5-102K	55,62	U5_snRNP_52K_protein	10,30	U5-102K	U5 snRNP 52K protein	24148	10421	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The human U5_snRNP_52K_protein -LRB- CD2BP2 -RRB- interacts with U5-102K -LRB- hPrp6 -RRB- , a U4/U6 .
20307692	0	U5-15kD	47,54	Polyglutamine_tract-binding_protein-1	0,37	U5-15kD	Polyglutamine tract-binding protein-1	10907	10084	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Polyglutamine_tract-binding_protein-1 binds to U5-15kD via a continuous 23-residue segment of the C-terminal domain .
15840814	0	U5_snRNP_52K_protein	10,30	U5-102K	55,62	U5 snRNP 52K protein	U5-102K	10421	24148	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The human U5_snRNP_52K_protein -LRB- CD2BP2 -RRB- interacts with U5-102K -LRB- hPrp6 -RRB- , a U4/U6 .
7489502	0	U6_snRNA	68,76	NS1	20,23	U6 snRNA	NS1	26827	10625	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	The influenza virus NS1 protein binds to a specific region in human U6_snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing .
22310390	0	U6_snRNA	29,37	Oct-1	69,74	U6 snRNA	Oct-1	26827	6580	Gene	Gene	regulation|nmod|START_ENTITY promoter|nsubj|regulation promoter|nmod|END_ENTITY	Negative regulation of human U6_snRNA promoter by p38 kinase through Oct-1 .
8595884	0	U6_snRNA	61,69	U1_snRNA	0,8	U6 snRNA	U1 snRNA	26827	26871	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	U1_snRNA promotes the selection of nearby 5 ' splice sites by U6_snRNA in mammalian cells .
23011765	0	U87	45,48	IDH1	31,35	U87	IDH1	641648	3417	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Expression of R132H mutational IDH1 in human U87 glioblastoma cells affects the SREBP1a pathway and induces cellular proliferation .
26770405	0	U87	69,72	IDH1	35,39	U87	IDH1	641648	3417	Gene	Gene	gene-chip|nmod|START_ENTITY END_ENTITY|nmod|gene-chip	Identifying the genes regulated by IDH1 via gene-chip in glioma cell U87 .
20013808	0	U87	83,86	heparin_affin_regulatory_peptide	43,75	U87	heparin affin regulatory peptide	641648	5764	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	Antitumorigenic effects of a mutant of the heparin_affin_regulatory_peptide on the U87 MG_glioblastoma cell line .
10830727	0	U87	141,144	tissue_inhibitor_of_metalloproteinases-2	75,115	U87	tissue inhibitor of metalloproteinases-2	641648	7077	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Antitumoral effects of defective_herpes_simplex_virus-mediated transfer of tissue_inhibitor_of_metalloproteinases-2 gene in malignant_glioma U87 in vitro : consequences for anti-cancer gene therapy .
20147737	0	UAF1	40,44	USP12	32,37	UAF1	USP12	57599	219333	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex .
17562711	0	UAP56	68,73	ATPase	36,42	UAP56	ATPase	7919	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Biochemical characterization of the ATPase and helicase activity of UAP56 , an essential pre-mRNA splicing and mRNA export factor .
16478985	0	UAP56	96,101	UL69	4,8	UAP56	UL69	7919	3077554(Tax:10359)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The UL69 transactivator protein of human_cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA .
15837191	0	UBA	17,20	Dsk2p	31,36	UBA	Dsk2p	855319(Tax:4932)	855319(Tax:4932)	Gene	Gene	domain|compound|START_ENTITY Structure|nmod|domain Structure|nmod|END_ENTITY	Structure of the UBA domain of Dsk2p in complex with ubiquitin molecular determinants for ubiquitin recognition .
25604990	0	UBA	9,12	TaUBA	0,5	UBA	TaUBA	100286392(Tax:4565)	100286392(Tax:4565)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	TaUBA , a UBA domain-containing protein in wheat -LRB- Triticum_aestivum_L . -RRB-
16215985	0	UBC13	38,43	RNF8	24,28	UBC13	RNF8	7334	9025	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation .
7565715	0	UBC3	36,40	CDC34	29,34	UBC3	CDC34	997	997	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Intragenic suppression among CDC34 -LRB- UBC3 -RRB- mutations defines a class of ubiquitin-conjugating catalytic domains .
7721857	0	UBC3	127,131	CDC34	120,125	UBC3	CDC34	851624(Tax:4932)	851624(Tax:4932)	Gene	Gene	enzyme|appos|START_ENTITY enzyme|appos|END_ENTITY	Increased ubiquitin expression suppresses the cell cycle defect associated with the yeast ubiquitin conjugating enzyme , CDC34 -LRB- UBC3 -RRB- .
8893823	0	UBC7	113,117	UBE2G	21,26	UBC7	UBE2G	7326	7326	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of UBE2G , encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. _ elegans .
12072434	0	UBC9	69,73	AP-2	21,25	UBC9	AP-2	7329	7020	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo .
17698038	0	UBC9	49,53	RAP80	0,5	UBC9	RAP80	7329	51720	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation .
20508617	0	UBCH8	20,25	FMS-like_tyrosine_kinase_3	41,67	UBCH8	FMS-like tyrosine kinase 3	9246	2322	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Ubiquitin conjugase UBCH8 targets active FMS-like_tyrosine_kinase_3 for proteasomal degradation .
7656587	0	UBE1	95,99	PCTK1	43,48	UBE1	PCTK1	7317	5127	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Physical linkage of the cdc2-related gene -LRB- PCTK1 -RRB- and the ubiquitin-activating_enzyme_E1 gene -LRB- UBE1 -RRB- on human Xp11 .3 .
1544321	0	UBE1	47,51	ubiquitin-activating_enzyme_E1	10,40	UBE1	ubiquitin-activating enzyme E1	7318	7318	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The human ubiquitin-activating_enzyme_E1 gene -LRB- UBE1 -RRB- mapped to band Xp11 .3 -- p11 .23 by fluorescence in situ hybridization .
24445050	0	UBE1L	72,77	epidermal_growth_factor_receptor	19,51	UBE1L	epidermal growth factor receptor	7318	1956	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of epidermal_growth_factor_receptor by curcumin-induced UBE1L in human bronchial epithelial cells .
8893823	0	UBE2G	21,26	UBC7	113,117	UBE2G	UBC7	7326	7326	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of UBE2G , encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. _ elegans .
12200128	0	UBE2I	54,59	SALL1	43,48	UBE2I	SALL1	7329	6299	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1 .
8921390	0	UBE2I	16,21	p53	40,43	UBE2I	p53	7329	7157	Gene	Gene	Associations|nmod|START_ENTITY Associations|nmod|END_ENTITY	Associations of UBE2I with RAD52 , UBL1 , p53 , and RAD51 proteins in a yeast two-hybrid system .
21229326	0	UBE2W	0,5	FANCL	21,26	UBE2W	FANCL	55284	55120	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi_anemia protein FANCD2 .
21633703	0	UBE3A	26,31	ASPM	76,80	UBE3A	ASPM	7337	259266	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Angelman_syndrome protein UBE3A interacts with primary_microcephaly protein ASPM , localizes to centrosomes and regulates chromosome segregation .
9143503	0	UBE3A	22,27	E6-AP	10,15	UBE3A	E6-AP	7337	7337	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The human E6-AP gene -LRB- UBE3A -RRB- encodes three potential protein isoforms generated by differential splicing .
17023019	0	UBE3A	21,26	E6AP	15,19	UBE3A	E6AP	7337	7337	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of E6AP -LRB- UBE3A -RRB- with human papillomavirus type 11 E6 protein .
21733131	0	UBE3A	0,5	MC1R	16,20	UBE3A	MC1R	7337	4157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	UBE3A regulates MC1R expression : a link to hypopigmentation in Angelman_syndrome .
26389696	0	UBE3C	60,65	E3_Ubiquitin_Ligase	28,47	UBE3C	E3 Ubiquitin Ligase	9690	158506	Gene	Gene	Activity|nmod|START_ENTITY Activity|amod|END_ENTITY	Liganded ERa Stimulates the E3_Ubiquitin_Ligase Activity of UBE3C to Facilitate Cell Proliferation .
26389696	0	UBE3C	60,65	ERa	9,12	UBE3C	ERa	9690	2099	Gene	Gene	Activity|nmod|START_ENTITY Stimulates|dobj|Activity Stimulates|nsubj|END_ENTITY	Liganded ERa Stimulates the E3_Ubiquitin_Ligase Activity of UBE3C to Facilitate Cell Proliferation .
21317885	0	UBE4B	0,5	p53	65,68	UBE4B	p53	10277	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53 .
25875638	0	UBE4B	39,44	p53	26,29	UBE4B	p53	10277	7157	Gene	Gene	Level|nmod|START_ENTITY Level|compound|END_ENTITY	Correction : Regulation of p53 Level by UBE4B in Breast_Cancer .
8641287	0	UBF	82,85	RNA_polymerase_I_associated_factor_53	0,37	UBF	RNA polymerase I associated factor 53	21429(Tax:10090)	64424(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	RNA_polymerase_I_associated_factor_53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription .
8609157	0	UBF	64,67	SL1	43,46	UBF	SL1	7343	9014	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	In vivo evidence that TATA-binding_protein / SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive .
23759948	0	UBIAD1	33,39	TERE1	26,31	UBIAD1	TERE1	29914	29914	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Ectopic expression of the TERE1 -LRB- UBIAD1 -RRB- protein inhibits growth of renal_clear_cell_carcinoma cells : altered metabolic phenotype associated with reactive oxygen species , nitric_oxide and SXR target genes involved in cholesterol and lipid metabolism .
25772619	0	UBIAD1	31,37	YY1	0,3	UBIAD1	YY1	29914	7528	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	YY1 positively regulates human UBIAD1 expression .
8921390	0	UBL1	34,38	RAD52	27,32	UBL1	RAD52	7341	5893	Gene	Gene	p53|dep|START_ENTITY p53|compound|END_ENTITY	Associations of UBE2I with RAD52 , UBL1 , p53 , and RAD51 proteins in a yeast two-hybrid system .
23726919	0	UBL5	6,10	coilin	34,40	UBL5	coilin	59286	8161	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	Human UBL5 protein interacts with coilin and meets the Cajal bodies .
19189687	0	UBL5	43,47	ubiquitin-like_5	49,65	UBL5	ubiquitin-like 5	59286	59286	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Identification of sequence variants in the UBL5 -LRB- ubiquitin-like_5 or BEACON -RRB- gene in obese children by PCR-SSCP : no evidence for association with obesity .
24458823	0	UBL5	26,30	ubiquitin-like_5	8,24	UBL5	ubiquitin-like 5	100513004	100513004	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Porcine ubiquitin-like_5 -LRB- UBL5 -RRB- gene : genomic organization , polymorphisms , mRNA cloning , splicing variants and association study .
11788588	0	UBP43	0,5	ISG15	35,40	UBP43	ISG15	24110(Tax:10090)	100038882(Tax:10090)	Gene	Gene	removes|nsubj|START_ENTITY removes|dobj|END_ENTITY	UBP43 -LRB- USP18 -RRB- specifically removes ISG15 from conjugated proteins .
18941237	0	UBP43	121,126	USP18	128,133	UBP43	USP18	11274	11274	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The level of hepatitis_B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 -LRB- USP18 -RRB- expression .
20558241	0	UBQLN1	0,6	SPEM1	22,27	UBQLN1	SPEM1	56085(Tax:10090)	74288(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	UBQLN1 interacts with SPEM1 and participates in spermiogenesis .
25582440	0	UBR4	60,64	KCMF1	0,5	UBR4	KCMF1	23352	56888	Gene	Gene	Links|dobj|START_ENTITY Links|nsubj|END_ENTITY	KCMF1 -LRB- potassium_channel_modulatory_factor_1 -RRB- Links RAD6 to UBR4 -LRB- ubiquitin_N-recognin_domain-containing_E3_ligase_4 -RRB- and Lysosome-Mediated Degradation .
25084275	0	UBR4	99,103	ubiquitin_protein_ligase_E3_component_N-recognin_4	47,97	UBR4	ubiquitin protein ligase E3 component N-recognin 4	69116(Tax:10090)	69116(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Time-of-day - and light-dependent expression of ubiquitin_protein_ligase_E3_component_N-recognin_4 -LRB- UBR4 -RRB- in the suprachiasmatic nucleus circadian clock .
21127351	0	UBR5	55,59	Transcription_factor_IIS	0,24	UBR5	Transcription factor IIS	51366	6920	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Transcription_factor_IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B. Elongation of transcription by mammalian RNA polymerase II -LRB- RNAPII -RRB- is regulated by specific factors , including transcription_factor_IIS -LRB- TFIIS -RRB- and positive transcription elongation factor b -LRB- P-TEFb -RRB- .
19174149	0	UBXD1	0,5	p97	12,15	UBXD1	p97	80700	4241	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	UBXD1 binds p97 through two independent binding sites .
26475856	0	UBXD1	62,67	p97	143,146	UBXD1	p97	80700	4241	Gene	Gene	UBX_Domain-containing_Protein_1|appos|START_ENTITY Region|nmod|UBX_Domain-containing_Protein_1 Modulates|nsubj|Region Modulates|dobj|Communication Communication|nmod|END_ENTITY	The N-terminal Region of the UBX_Domain-containing_Protein_1 -LRB- UBXD1 -RRB- Modulates Interdomain Communication within the Valosin-containing Protein p97 .
23545497	0	UBXN1	0,5	MAVS	90,94	UBXN1	MAVS	51035	57506	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS .
24457952	0	UCA1	20,24	p27	72,75	UCA1	p27	652995	3429	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	Long non-coding RNA UCA1 promotes breast_tumor growth by suppression of p27 -LRB- Kip1 -RRB- .
21678139	0	UCH-L1	25,31	PTOV1	0,5	UCH-L1	PTOV1	22223(Tax:10090)	84113(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development .
17449248	0	UCH-L1	122,128	ubiquitin_C-terminal_hydrolase-L1	87,120	UCH-L1	ubiquitin C-terminal hydrolase-L1	7345	7345	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationship , kinetic mechanism , and selectivity for a new class of ubiquitin_C-terminal_hydrolase-L1 -LRB- UCH-L1 -RRB- inhibitors .
18985619	0	UCH-L1	63,69	ubiquitin_C-terminal_hydrolase-L1	28,61	UCH-L1	ubiquitin C-terminal hydrolase-L1	7345	7345	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A new role for the neuronal ubiquitin_C-terminal_hydrolase-L1 -LRB- UCH-L1 -RRB- in podocyte process formation and podocyte injury in human glomerulopathies .
21309726	0	UCH-L1	58,64	ubiquitin_C-terminal_hydrolase-L1	23,56	UCH-L1	ubiquitin C-terminal hydrolase-L1	7345	7345	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Biokinetic analysis of ubiquitin_C-terminal_hydrolase-L1 -LRB- UCH-L1 -RRB- in severe traumatic_brain_injury patient biofluids .
23996067	0	UCH-L1	59,65	ubiquitin_C-terminal_hydrolase_L1	24,57	UCH-L1	ubiquitin C-terminal hydrolase L1	7345	7345	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Prognostic relevance of ubiquitin_C-terminal_hydrolase_L1 -LRB- UCH-L1 -RRB- mRNA and protein expression in breast_cancer patients .
10900392	0	UCH-L1	79,85	ubiquitin_carboxy-terminal_hydrolase_L1	38,77	UCH-L1	ubiquitin carboxy-terminal hydrolase L1	7345	7345	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between a polymorphism of ubiquitin_carboxy-terminal_hydrolase_L1 -LRB- UCH-L1 -RRB- gene and sporadic Parkinson 's _ disease .
2346723	0	UCHL1	44,49	CD45R	20,25	UCHL1	CD45R	7345	5788	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	The distribution of CD45R , CD29 and CD45RO -LRB- UCHL1 -RRB- antigens in mature CD4 positive T-cell_leukaemias .
24950120	0	UCHL1	101,106	ubiquitin_carboxy-terminal_hydrolase_L1	60,99	UCHL1	ubiquitin carboxy-terminal hydrolase L1	7345	7345	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin_carboxy-terminal_hydrolase_L1 -LRB- UCHL1 -RRB- expression in the pathogenesis of Alzheimer 's _ disease .
16819549	0	UCP	7,10	pVHL	19,23	UCP	pVHL	7350	7428	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis .
12044870	0	UCP-1	53,58	PPAR_gamma	21,31	UCP-1	PPAR gamma	7350	5468	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Differential role of PPAR_gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes .
11277995	0	UCP-1	19,24	TNF-alpha	0,9	UCP-1	TNF-alpha	24860(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TNF-alpha inhibits UCP-1 expression in brown adipocytes via ERKs .
12044870	0	UCP-1	53,58	TNF-alpha	79,88	UCP-1	TNF-alpha	7350	7124	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Differential role of PPAR_gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes .
12967645	0	UCP-2	41,46	Interleukin-1beta	0,17	UCP-2	Interleukin-1beta	54315(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY down-regulates|dobj|mRNA down-regulates|nsubj|END_ENTITY	Interleukin-1beta swiftly down-regulates UCP-2 mRNA in beta-cells by mechanisms not directly coupled to toxicity .
9299560	0	UCP-2	17,22	PPAR	42,46	UCP-2	PPAR	22228(Tax:10090)	19013(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells .
10089012	0	UCP-2	36,41	UCP-3	42,47	UCP-2	UCP-3	7351	7352	Gene	Gene	marker|nmod|START_ENTITY Association|nmod|marker Association|dep|cluster cluster|compound|END_ENTITY	Association between a marker in the UCP-2 / UCP-3 gene cluster and genetic susceptibility to anorexia_nervosa .
11587528	0	UCP-2	45,50	UCP-3	30,35	UCP-2	UCP-3	22228(Tax:10090)	22229(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Concordant mRNA expression of UCP-3 , but not UCP-2 , with mitochondrial_thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice .
9832429	0	UCP-2	117,122	UCP-3	124,129	UCP-2	UCP-3	22228(Tax:10090)	22229(Tax:10090)	Gene	Gene	UCP-1|dep|START_ENTITY UCP-1|dep|END_ENTITY	Peroxisome_proliferator-activated_receptors_gamma_and_alpha mediate in vivo regulation of uncoupling_protein -LRB- UCP-1 , UCP-2 , UCP-3 -RRB- gene expression .
12756242	0	UCP-2	286,291	peroxisome_proliferator-activated_receptor-alpha	212,260	UCP-2	peroxisome proliferator-activated receptor-alpha	54315(Tax:10116)	25747(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling_protein_2 -LRB- UCP-2 -RRB- expression : evidence for peroxisome_proliferator-activated_receptor-alpha independent induction of UCP-2 expression .
12756242	0	UCP-2	180,185	uncoupling_protein_2	158,178	UCP-2	uncoupling protein 2	54315(Tax:10116)	54315(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling_protein_2 -LRB- UCP-2 -RRB- expression : evidence for peroxisome_proliferator-activated_receptor-alpha independent induction of UCP-2 expression .
17916951	0	UCP-2	188,193	uncoupling_protein_2	166,186	UCP-2	uncoupling protein 2	7351	7351	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Increased plasma manganese , partially reduced ascorbate , 1 and absence of mitochondrial oxidative stress in type 2 diabetes_mellitus : implications for the superoxide uncoupling_protein_2 -LRB- UCP-2 -RRB- pathway .
25077985	0	UCP-2	70,75	uncoupling_protein_2	48,68	UCP-2	uncoupling protein 2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Antagonistic effect of TNF-alpha and insulin on uncoupling_protein_2 -LRB- UCP-2 -RRB- expression and vascular_damage .
10873645	0	UCP-3	26,31	PPARalpha	85,94	UCP-3	PPARalpha	25708(Tax:10116)	25747(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPARalpha and PPARgamma ligands .
10089012	0	UCP-3	42,47	UCP-2	36,41	UCP-3	UCP-2	7352	7351	Gene	Gene	cluster|compound|START_ENTITY Association|dep|cluster Association|nmod|marker marker|nmod|END_ENTITY	Association between a marker in the UCP-2 / UCP-3 gene cluster and genetic susceptibility to anorexia_nervosa .
11587528	0	UCP-3	30,35	UCP-2	45,50	UCP-3	UCP-2	22229(Tax:10090)	22228(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Concordant mRNA expression of UCP-3 , but not UCP-2 , with mitochondrial_thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice .
9832429	0	UCP-3	124,129	UCP-2	117,122	UCP-3	UCP-2	22229(Tax:10090)	22228(Tax:10090)	Gene	Gene	UCP-1|dep|START_ENTITY UCP-1|dep|END_ENTITY	Peroxisome_proliferator-activated_receptors_gamma_and_alpha mediate in vivo regulation of uncoupling_protein -LRB- UCP-1 , UCP-2 , UCP-3 -RRB- gene expression .
20101261	0	UCP1	111,115	ERRalpha	93,101	UCP1	ERRalpha	7350	2101	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Human fetal mesenchymal stem cells differentiate into brown and white adipocytes : a role for ERRalpha in human UCP1 expression .
24129192	0	UCP1	139,143	FABP3	0,5	UCP1	FABP3	22227(Tax:10090)	14077(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	FABP3 and brown adipocyte-characteristic mitochondrial fatty_acid oxidation enzymes are induced in beige cells in a different pathway from UCP1 .
17164436	0	UCP1	10,14	IL-1beta	75,83	UCP1	IL-1beta	22227(Tax:10090)	16176(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice .
24416310	0	UCP1	52,56	IL-6	8,12	UCP1	IL-6	22227(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Role of IL-6 in exercise training - and cold-induced UCP1 expression in subcutaneous white adipose tissue .
10825155	1	UCP1	102,106	UCP2	67,71	UCP1	UCP2	22227(Tax:10090)	22228(Tax:10090)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis .
11179956	0	UCP1	36,40	UCP2	106,110	UCP1	UCP2	22227(Tax:10090)	7351	Gene	Gene	relationships|nmod|START_ENTITY relationships|dep|analysis analysis|nmod|END_ENTITY	Structure-function relationships in UCP1 , UCP2 and chimeras : EPR analysis and retinoic_acid activation of UCP2 .
18626658	0	UCP1	75,79	UCP2	28,32	UCP1	UCP2	7350	7351	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Fatty_acids do not activate UCP2 in pancreatic beta cells : comparison with UCP1 .
15329462	0	UCP1	61,65	uncoupling_protein-1	39,59	UCP1	uncoupling protein-1	22227(Tax:10090)	22227(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Effects of ethanol on the induction of uncoupling_protein-1 -LRB- UCP1 -RRB- mRNA in the mouse brown adipose tissue .
11369767	0	UCP1	104,108	uncoupling_protein_1	82,102	UCP1	uncoupling protein 1	7350	7350	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	beta-Adrenergic activation of p38_MAP_kinase in adipocytes : cAMP induction of the uncoupling_protein_1 -LRB- UCP1 -RRB- gene requires p38_MAP_kinase .
16933999	0	UCP1	31,35	uncoupling_protein_1	4,24	UCP1	uncoupling protein 1	751863(Tax:9823)	751863(Tax:9823)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The uncoupling_protein_1 gene -LRB- UCP1 -RRB- is disrupted in the pig lineage : a genetic explanation for poor thermoregulation in piglets .
22790465	0	UCP1	38,42	uncoupling_protein_1	16,36	UCP1	uncoupling protein 1	7350	7350	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the uncoupling_protein_1 -LRB- UCP1 -RRB- on the development of obesity and type_2_diabetes_mellitus .
9665669	0	UCP1	46,50	uncoupling_protein_1	24,44	UCP1	uncoupling protein 1	7350	7350	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA polymorphism in the uncoupling_protein_1 -LRB- UCP1 -RRB- gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts .
26714029	0	UCP2	60,64	Insulin	28,35	UCP2	Insulin	7351	3630	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|compound|END_ENTITY	Correction : Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells .
18047787	0	UCP2	62,66	MyoD	85,89	UCP2	MyoD	22228(Tax:10090)	17927(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of the promoter activity of the mouse UCP2 and UCP3 genes by MyoD and myogenin .
16366736	0	UCP2	48,52	Sirt1	0,5	UCP2	Sirt1	22228(Tax:10090)	93759(Tax:10090)	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells .
26714029	0	UCP2	60,64	Sirt1	12,17	UCP2	Sirt1	7351	23411	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|compound|END_ENTITY	Correction : Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic b Cells .
21364658	0	UCP2	23,27	TGFb	31,35	UCP2	TGFb	7351	7040	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Negative regulation of UCP2 by TGFb signaling characterizes low and intermediate-grade primary breast_cancer .
10825155	1	UCP2	67,71	UCP1	102,106	UCP2	UCP1	22228(Tax:10090)	22227(Tax:10090)	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis .
11179956	0	UCP2	106,110	UCP1	36,40	UCP2	UCP1	7351	22227(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY relationships|dep|analysis relationships|nmod|END_ENTITY	Structure-function relationships in UCP1 , UCP2 and chimeras : EPR analysis and retinoic_acid activation of UCP2 .
18626658	0	UCP2	28,32	UCP1	75,79	UCP2	UCP1	7351	7350	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Fatty_acids do not activate UCP2 in pancreatic beta cells : comparison with UCP1 .
15682648	0	UCP2	10,14	UCP2	81,85	UCP2	UCP2	54315(Tax:10116)	54315(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Decreased UCP2 mRNA expression in rat stomach following vagotomy : novel role for UCP2 as free radical scavenger in the stomach ?
15682648	0	UCP2	81,85	UCP2	10,14	UCP2	UCP2	54315(Tax:10116)	54315(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Decreased UCP2 mRNA expression in rat stomach following vagotomy : novel role for UCP2 as free radical scavenger in the stomach ?
19242784	0	UCP2	69,73	UCP3	75,79	UCP2	UCP3	54315(Tax:10116)	25708(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2 , UCP3 , UCP4 , and UCP5 show different patterns in rat and mice tissues .
19242784	0	UCP2	69,73	UCP4	81,85	UCP2	UCP4	54315(Tax:10116)	85262(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2 , UCP3 , UCP4 , and UCP5 show different patterns in rat and mice tissues .
25431415	0	UCP2	27,31	Uncoupling_protein_2	0,20	UCP2	Uncoupling protein 2	7351	7351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Uncoupling_protein_2 gene -LRB- UCP2 -RRB- 45-bp I/D polymorphism is associated with adiposity among Malaysian women .
21857957	0	UCP2	12,16	iNOS	20,24	UCP2	iNOS	22228(Tax:10090)	18126(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Deletion of UCP2 in iNOS deficient mice reduces the severity of the disease during experimental autoimmune encephalomyelitis .
12716765	0	UCP2	41,45	insulin	78,85	UCP2	insulin	7351	3630	Gene	Gene	promoter|nmod|START_ENTITY polymorphism|nmod|promoter contributes|nsubj|polymorphism contributes|nmod|variation variation|nmod|secretion secretion|compound|END_ENTITY	A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects .
19065272	0	UCP2	13,17	insulin	80,87	UCP2	insulin	7351	3630	Gene	Gene	Mutations|nmod|START_ENTITY reveal|nsubj|Mutations reveal|dobj|role role|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	Mutations in UCP2 in congenital_hyperinsulinism reveal a role for regulation of insulin secretion .
22349573	0	UCP2	13,17	insulin	56,63	UCP2	insulin	7351	3630	Gene	Gene	>|compound|START_ENTITY >|acl:relcl|protects protects|nmod|resistance resistance|compound|END_ENTITY	The frequent UCP2 -866 G > A polymorphism protects against insulin resistance and is associated with obesity : a study of obesity and related metabolic traits among 17 636 Danes .
18795068	0	UCP2	14,18	p38	33,36	UCP2	p38	7351	1432	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Modulation of UCP2 expression by p38 -- a link to cardioprotection .
18839467	0	UCP2	45,49	uncoupling_protein-2	23,43	UCP2	uncoupling protein-2	7351	7351	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role for mitochondrial uncoupling_protein-2 -LRB- UCP2 -RRB- in hyperhomocysteinemia and venous_thrombosis risk ?
23088859	0	UCP2	59,63	uncoupling_protein-2	37,57	UCP2	uncoupling protein-2	7351	7351	Gene	Gene	Localisation|appos|START_ENTITY Localisation|nmod|END_ENTITY	Localisation and characterisation of uncoupling_protein-2 -LRB- UCP2 -RRB- in the human preterm placenta .
10849580	0	UCP2	83,87	uncoupling_protein_2	61,81	UCP2	uncoupling protein 2	7351	7351	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Depot-related and thiazolidinedione-responsive expression of uncoupling_protein_2 -LRB- UCP2 -RRB- in human adipocytes .
15231722	0	UCP2	30,34	uncoupling_protein_2	8,28	UCP2	uncoupling protein 2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Role of uncoupling_protein_2 -LRB- UCP2 -RRB- expression and 1alpha , 25-dihydroxyvitamin_D3 in modulating adipocyte apoptosis .
21779625	0	UCP2	34,38	uncoupling_protein_2	12,32	UCP2	uncoupling protein 2	7351	7351	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of uncoupling_protein_2 -LRB- UCP2 -RRB- on the development of type_2_diabetes_mellitus and its chronic complications .
22134120	0	UCP2	75,79	uncoupling_protein_2	53,73	UCP2	uncoupling protein 2	7351	7351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The presence of the -866 A/55Val/Ins haplotype in the uncoupling_protein_2 -LRB- UCP2 -RRB- gene is associated with decreased UCP2 gene expression in human retina .
23314523	0	UCP2	36,40	uncoupling_protein_2	14,34	UCP2	uncoupling protein 2	7351	7351	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Mitochondrial uncoupling_protein_2 -LRB- UCP2 -RRB- gene polymorphisms are associated with childhood obesity and related metabolic_disorders .
9710252	0	UCP2	78,82	uncoupling_protein_2	56,76	UCP2	uncoupling protein 2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and promoter function of the mouse uncoupling_protein_2 -LRB- UCP2 -RRB- gene .
26915802	0	UCP3	0,4	Hax-1	24,29	UCP3	Hax-1	22229(Tax:10090)	23897(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion .
26848765	0	UCP3	32,36	Insulin	40,47	UCP3	Insulin	7352	3630	Gene	Gene	START_ENTITY|nmod|Resistance Resistance|compound|END_ENTITY	Effect of -55 CT Polymorphism of UCP3 on Insulin Resistance and Cardiovascular Risk Factors after a High Protein/Low Carbohydrate versus a Standard Hypocaloric Diet .
19242784	0	UCP3	75,79	UCP2	69,73	UCP3	UCP2	25708(Tax:10116)	54315(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2 , UCP3 , UCP4 , and UCP5 show different patterns in rat and mice tissues .
19242784	0	UCP3	75,79	UCP4	81,85	UCP3	UCP4	25708(Tax:10116)	85262(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2 , UCP3 , UCP4 , and UCP5 show different patterns in rat and mice tissues .
12351640	0	UCP3	22,26	Uncoupling_protein-3	0,20	UCP3	Uncoupling protein-3	7352	7352	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Uncoupling_protein-3 -LRB- UCP3 -RRB- mRNA expression in reconstituted human muscle after myoblast transplantation in RAG2 - / - / gamma_c / C5 -LRB- - -RRB- immunodeficient mice .
11045607	0	UCP3	84,88	hUCP3	90,95	UCP3	hUCP3	7352	7352	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional characterization of the 5 ' - flanking and the promoter region of the human UCP3 -LRB- hUCP3 -RRB- gene .
10454128	0	UCP3	54,58	uncoupling_protein-3	32,52	UCP3	uncoupling protein-3	7352	7352	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Uncoupling_protein-2 -LRB- UCP2 -RRB- and uncoupling_protein-3 -LRB- UCP3 -RRB- expression in adipose tissue and skeletal muscle in humans .
10329378	0	UCP3	90,94	uncoupling_protein_3	68,88	UCP3	uncoupling protein 3	7352	7352	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of the 5 ' flanking region of the human uncoupling_protein_3 -LRB- UCP3 -RRB- gene .
11151767	0	UCP3	74,78	uncoupling_protein_3	52,72	UCP3	uncoupling protein 3	7352	7352	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence that single nucleotide polymorphism in the uncoupling_protein_3 -LRB- UCP3 -RRB- gene influences fat distribution in women of European and Asian origin .
22811361	0	UCP3	61,65	uncoupling_protein_3	39,59	UCP3	uncoupling protein 3	7352	7352	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Relationship of -55 C/T polymorphism of uncoupling_protein_3 -LRB- UCP3 -RRB- gene with metabolic_syndrome by ATP III classification .
9642158	0	UCP3	39,43	uncoupling_protein_3	17,37	UCP3	uncoupling protein 3	22229(Tax:10090)	22229(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Up-regulation of uncoupling_protein_3 -LRB- UCP3 -RRB- mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles .
19242784	0	UCP4	81,85	UCP2	69,73	UCP4	UCP2	85262(Tax:10116)	54315(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2 , UCP3 , UCP4 , and UCP5 show different patterns in rat and mice tissues .
19242784	0	UCP4	81,85	UCP3	75,79	UCP4	UCP3	85262(Tax:10116)	25708(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2 , UCP3 , UCP4 , and UCP5 show different patterns in rat and mice tissues .
12565992	0	UDG	38,41	uracil_DNA_glycosylase	14,36	UDG	uracil DNA glycosylase	7374	7374	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of uracil_DNA_glycosylase -LRB- UDG -RRB- does not affect cellular sensitivity to thymidylate_synthase -LRB- TS -RRB- inhibition .
26786882	0	UDP-Glucuronosyltransferase	19,46	UGT	48,51	UDP-Glucuronosyltransferase	UGT	7361	7361	Gene	Gene	Activity|compound|START_ENTITY Activity|appos|END_ENTITY	Detection of Total UDP-Glucuronosyltransferase -LRB- UGT -RRB- Activity in Melanoma Cells .
18717819	0	UDP-glucose_dehydrogenase	58,83	ERK	104,107	UDP-glucose dehydrogenase	ERK	7358	5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Epstein-Barr_virus latent membrane protein 2A upregulates UDP-glucose_dehydrogenase gene expression via ERK and PI3K/Akt pathway .
815919	0	UDP-glucuronosyl_transferase	39,67	glycine-N-acyltransferase	123,148	UDP-glucuronosyl transferase	glycine-N-acyltransferase	24862(Tax:10116)	293779(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Drug conjugation in Gunn_rats : reduced UDP-glucuronosyl_transferase and UDP-glucosyl transferase activities with increased glycine-N-acyltransferase activity .
14709899	0	UDP-glucuronosyltransferase	76,103	UGT	105,108	UDP-glucuronosyltransferase	UGT	24862(Tax:10116)	24862(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase -LRB- UGT -RRB- activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats : possible involvement of UGT-P450 interactions .
24401909	0	UDP-glucuronosyltransferase	10,37	UGT	115,118	UDP-glucuronosyltransferase	UGT	54658	7361	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	Truncated UDP-glucuronosyltransferase -LRB- UGT -RRB- from a Crigler-Najjar_syndrome_type_II patient colocalizes with intact UGT in the endoplasmic reticulum .
9765507	0	UDP-glucuronosyltransferase	30,57	UGT1A	58,63	UDP-glucuronosyltransferase	UGT1A	7361	7361	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium .
23099197	0	UDP-glucuronosyltransferase	38,65	UGT1A1	67,73	UDP-glucuronosyltransferase	UGT1A1	54658	54658	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel mutation in UDP-glucuronosyltransferase -LRB- UGT1A1 -RRB- gene in a child with neonatal unconjugated hyperbilirubinemia .
9435989	0	UDP-glucuronosyltransferase-1	23,52	UGT1	54,58	UDP-glucuronosyltransferase-1	UGT1	54658	54658	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic defects of the UDP-glucuronosyltransferase-1 -LRB- UGT1 -RRB- gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias .
21317540	0	UDP-glucuronosyltransferase_1A	70,100	UGT1A	102,107	UDP-glucuronosyltransferase 1A	UGT1A	54658	54658	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Interpretation of the effects of protein_kinase_C inhibitors on human UDP-glucuronosyltransferase_1A -LRB- UGT1A -RRB- proteins in cellulo .
16399344	0	UDP-glucuronosyltransferase_1A1	46,77	Ah_receptor	12,23	UDP-glucuronosyltransferase 1A1	Ah receptor	54658	196	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of Ah_receptor in induction of human UDP-glucuronosyltransferase_1A1 .
10908299	0	UDP-glucuronosyltransferase_1A7	68,99	UGT1A7	101,107	UDP-glucuronosyltransferase 1A7	UGT1A7	154516(Tax:10116)	154516(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase_1A7 -LRB- UGT1A7 -RRB- gene in rat hepatocytes .
22210424	0	UDP-glucuronosyltransferase_1A9	15,46	UGT1A9	48,54	UDP-glucuronosyltransferase 1A9	UGT1A9	54600	54600	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of UDP-glucuronosyltransferase_1A9 -LRB- UGT1A9 -RRB- gene polymorphism with kidney allograft function .
23053953	0	UDP-glucuronosyltransferase_2B17	14,46	DHFR	86,90	UDP-glucuronosyltransferase 2B17	DHFR	7367	1719	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Evaluation of UDP-glucuronosyltransferase_2B17 -LRB- UGT2B17 -RRB- and dihydrofolate_reductase -LRB- DHFR -RRB- genes deletion and the expression level of NGX6 mRNA in breast_cancer .
12629580	0	UDP-glucuronosyltransferase_2B7	27,58	UGT2B7	60,66	UDP-glucuronosyltransferase 2B7	UGT2B7	7364	7364	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence variations in the UDP-glucuronosyltransferase_2B7 -LRB- UGT2B7 -RRB- gene : identification of 10 novel single nucleotide polymorphisms -LRB- SNPs -RRB- and analysis of their relevance to morphine glucuronidation in cancer patients .
12220528	0	UDP-glucuronosyltransferase_family_1	40,76	UGT1	78,82	UDP-glucuronosyltransferase family 1	UGT1	24861(Tax:10116)	24861(Tax:10116)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Accelerated degradation of mislocalized UDP-glucuronosyltransferase_family_1 -LRB- UGT1 -RRB- proteins in Gunn rat hepatocytes .
18324905	0	UDP_glucuronosyltranferase	44,70	UGT1A1	72,78	UDP glucuronosyltranferase	UGT1A1	54658	54658	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Rare TA repeats in promoter TATA box of the UDP_glucuronosyltranferase -LRB- UGT1A1 -RRB- gene in Croatian subjects .
10220484	0	UDP_glucuronosyltransferases	19,47	UGT1A6	49,55	UDP glucuronosyltransferases	UGT1A6	135152	135152	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|END_ENTITY	Induction of human UDP_glucuronosyltransferases -LRB- UGT1A6 , UGT1A9 , and UGT2B7 -RRB- by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells .
11979512	0	UFD1L	105,110	ubiquitin_fusion_degradation_1_like	63,98	UFD1L	ubiquitin fusion degradation 1 like	7353	7353	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional characterization of the 5 ' flanking region of human ubiquitin_fusion_degradation_1_like gene -LRB- UFD1L -RRB- .
21410962	0	UGRP1	44,49	Uteroglobin-Related_Protein_1	13,42	UGRP1	Uteroglobin-Related Protein 1	117156	117156	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variation in Uteroglobin-Related_Protein_1 -LRB- UGRP1 -RRB- gene is associated with allergic_rhinitis in Singapore Chinese .
21170691	0	UGRP1	105,110	uteroglobin-related_protein_1	74,103	UGRP1	uteroglobin-related protein 1	117156	117156	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	The -112 G > A polymorphism of the secretoglobin_3A2 -LRB- SCGB3A2 -RRB- gene encoding uteroglobin-related_protein_1 -LRB- UGRP1 -RRB- increases risk for the development of Graves ' _ disease in subsets of patients with elevated levels of immunoglobulin_E .
24710847	0	UGRP2	26,31	SCGB3A1	17,24	UGRP2	SCGB3A1	92304	92304	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Investigation of SCGB3A1 -LRB- UGRP2 -RRB- gene arrays in patients with nasal_polyposis .
26786882	0	UGT	48,51	UDP-Glucuronosyltransferase	19,46	UGT	UDP-Glucuronosyltransferase	7361	7361	Gene	Gene	Activity|appos|START_ENTITY Activity|compound|END_ENTITY	Detection of Total UDP-Glucuronosyltransferase -LRB- UGT -RRB- Activity in Melanoma Cells .
14709899	0	UGT	105,108	UDP-glucuronosyltransferase	76,103	UGT	UDP-glucuronosyltransferase	24862(Tax:10116)	24862(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase -LRB- UGT -RRB- activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats : possible involvement of UGT-P450 interactions .
24401909	0	UGT	115,118	UDP-glucuronosyltransferase	10,37	UGT	UDP-glucuronosyltransferase	7361	54658	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	Truncated UDP-glucuronosyltransferase -LRB- UGT -RRB- from a Crigler-Najjar_syndrome_type_II patient colocalizes with intact UGT in the endoplasmic reticulum .
23298683	0	UGT	80,83	uridine_diphosphate_glycosyltransferase	39,78	UGT	uridine diphosphate glycosyltransferase	7361	7361	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional and structural variation of uridine_diphosphate_glycosyltransferase -LRB- UGT -RRB- gene of Stevia rebaudiana-UGTSr involved in the synthesis of rebaudioside_A .
9435989	0	UGT1	54,58	UDP-glucuronosyltransferase-1	23,52	UGT1	UDP-glucuronosyltransferase-1	54658	54658	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic defects of the UDP-glucuronosyltransferase-1 -LRB- UGT1 -RRB- gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias .
12220528	0	UGT1	78,82	UDP-glucuronosyltransferase_family_1	40,76	UGT1	UDP-glucuronosyltransferase family 1	24861(Tax:10116)	24861(Tax:10116)	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Accelerated degradation of mislocalized UDP-glucuronosyltransferase_family_1 -LRB- UGT1 -RRB- proteins in Gunn rat hepatocytes .
9765507	0	UGT1A	58,63	UDP-glucuronosyltransferase	30,57	UGT1A	UDP-glucuronosyltransferase	7361	7361	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium .
21317540	0	UGT1A	102,107	UDP-glucuronosyltransferase_1A	70,100	UGT1A	UDP-glucuronosyltransferase 1A	54658	54658	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Interpretation of the effects of protein_kinase_C inhibitors on human UDP-glucuronosyltransferase_1A -LRB- UGT1A -RRB- proteins in cellulo .
23099197	0	UGT1A1	67,73	UDP-glucuronosyltransferase	38,65	UGT1A1	UDP-glucuronosyltransferase	54658	54658	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a novel mutation in UDP-glucuronosyltransferase -LRB- UGT1A1 -RRB- gene in a child with neonatal unconjugated hyperbilirubinemia .
18324905	0	UGT1A1	72,78	UDP_glucuronosyltranferase	44,70	UGT1A1	UDP glucuronosyltranferase	54658	54658	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Rare TA repeats in promoter TATA box of the UDP_glucuronosyltranferase -LRB- UGT1A1 -RRB- gene in Croatian subjects .
17627617	0	UGT1A1	18,24	UGT1A1	8,14	UGT1A1	UGT1A1	54658	54658	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Role of UGT1A1 * 6 , UGT1A1 * 28 and ABCG2 c. 421C > A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients .
17627617	0	UGT1A1	8,14	UGT1A1	18,24	UGT1A1	UGT1A1	54658	54658	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Role of UGT1A1 * 6 , UGT1A1 * 28 and ABCG2 c. 421C > A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients .
22960892	0	UGT1A1	17,23	UGT1A1	27,33	UGT1A1	UGT1A1	54658	54658	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	Polymorphisms of UGT1A1 * 6 , UGT1A1 * 27 _ UGT1A1 * 28 in three major ethnic groups from Malaysia .
22960892	0	UGT1A1	27,33	UGT1A1	17,23	UGT1A1	UGT1A1	54658	54658	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Polymorphisms of UGT1A1 * 6 , UGT1A1 * 27 _ UGT1A1 * 28 in three major ethnic groups from Malaysia .
23537215	0	UGT1A1	43,49	UGT1A1	53,59	UGT1A1	UGT1A1	54658	54658	Gene	Gene	*|compound|START_ENTITY *|nummod|END_ENTITY	The association between heterozygosity for UGT1A1 * 6 , UGT1A1 * 28 , and variation in the serum total-bilirubin level in healthy young Japanese adults .
23537215	0	UGT1A1	53,59	UGT1A1	43,49	UGT1A1	UGT1A1	54658	54658	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	The association between heterozygosity for UGT1A1 * 6 , UGT1A1 * 28 , and variation in the serum total-bilirubin level in healthy young Japanese adults .
17479406	0	UGT1A6	41,47	CYP1A1	25,31	UGT1A6	CYP1A1	54578	1543	Gene	Gene	UGT1A7|appos|START_ENTITY UGT1A7|compound|END_ENTITY	Genetic polymorphisms in CYP1A1 , CYP2D6 , UGT1A6 , UGT1A7 , and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population .
10220484	0	UGT1A6	49,55	UDP_glucuronosyltransferases	19,47	UGT1A6	UDP glucuronosyltransferases	135152	135152	Gene	Gene	Induction|dep|START_ENTITY Induction|nmod|END_ENTITY	Induction of human UDP_glucuronosyltransferases -LRB- UGT1A6 , UGT1A9 , and UGT2B7 -RRB- by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells .
20196639	0	UGT1A6	68,74	protein_kinase_C_delta	9,31	UGT1A6	protein kinase C delta	54578	5580	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Role for protein_kinase_C_delta in the functional activity of human UGT1A6 : implications for drug-drug interactions between PKC inhibitors and UGT1A6 .
10908299	0	UGT1A7	101,107	UDP-glucuronosyltransferase_1A7	68,99	UGT1A7	UDP-glucuronosyltransferase 1A7	154516(Tax:10116)	154516(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase_1A7 -LRB- UGT1A7 -RRB- gene in rat hepatocytes .
12042666	0	UGT1A8	79,85	UGT1A8	89,95	UGT1A8	UGT1A8	54576	54576	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8 * 1 , UGT1A8 * 2 and UGT1A8 * 3 .
12042666	0	UGT1A8	89,95	UGT1A8	79,85	UGT1A8	UGT1A8	54576	54576	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8 * 1 , UGT1A8 * 2 and UGT1A8 * 3 .
22210424	0	UGT1A9	48,54	UDP-glucuronosyltransferase_1A9	15,46	UGT1A9	UDP-glucuronosyltransferase 1A9	54600	54600	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of UDP-glucuronosyltransferase_1A9 -LRB- UGT1A9 -RRB- gene polymorphism with kidney allograft function .
15115919	0	UGT1A9	53,59	UGT1A9	66,72	UGT1A9	UGT1A9	54600	54600	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel polymorphism in the promoter region of human UGT1A9 gene -LRB- UGT1A9 * 22 -RRB- and its effects on the transcriptional activity .
15115919	0	UGT1A9	66,72	UGT1A9	53,59	UGT1A9	UGT1A9	54600	54600	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel polymorphism in the promoter region of human UGT1A9 gene -LRB- UGT1A9 * 22 -RRB- and its effects on the transcriptional activity .
9052741	0	UGT2B1	57,63	HNF1_alpha	0,10	UGT2B1	HNF1 alpha	286954(Tax:10116)	24817(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	HNF1_alpha activates the rat UDP glucuronosyltransferase UGT2B1 gene promoter .
26528103	0	UGT2B17	57,64	ESR1	51,55	UGT2B17	ESR1	7367	2099	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Polymorphisms of estrogen metabolism-related genes ESR1 , UGT2B17 , and UGT1A1 are not associated with osteoporosis in surgically menopausal Japanese women .
12629580	0	UGT2B7	60,66	UDP-glucuronosyltransferase_2B7	27,58	UGT2B7	UDP-glucuronosyltransferase 2B7	7364	7364	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sequence variations in the UDP-glucuronosyltransferase_2B7 -LRB- UGT2B7 -RRB- gene : identification of 10 novel single nucleotide polymorphisms -LRB- SNPs -RRB- and analysis of their relevance to morphine glucuronidation in cancer patients .
9387929	0	UHG	19,22	U22	4,7	UHG	U22	23642	9304	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The U22 host gene -LRB- UHG -RRB- : chromosomal localization of UHG and distribution of U22 small nucleolar RNA .
23463006	0	UHRF1	0,5	DNMT1	14,19	UHRF1	DNMT1	18140(Tax:10090)	13433(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9 .
26851214	0	UHRF1	0,5	Dnmt1	20,25	UHRF1	Dnmt1	406350(Tax:7955)	30430(Tax:7955)	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|END_ENTITY	UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development .
19056828	0	UHRF1	0,5	G9a	12,15	UHRF1	G9a	29128	10919	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells .
25765655	0	UHRF1	48,53	G9a	23,26	UHRF1	G9a	29128	10919	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation .
20037778	0	UHRF1	0,5	MDR1	15,19	UHRF1	MDR1	29128	5243	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|transcription transcription|compound|END_ENTITY	UHRF1 inhibits MDR1 gene transcription and sensitizes breast_cancer cells to anticancer drugs .
18772891	0	UHRF1	54,59	SRA	42,45	UHRF1	SRA	29128	4481	Gene	Gene	START_ENTITY|nsubj|Recognition Recognition|nmod|DNA DNA|nmod|protein protein|compound|END_ENTITY	Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism .
26368281	0	UHRF1	66,71	SRA	52,55	UHRF1	SRA	29128	4481	Gene	Gene	Domain|nmod|START_ENTITY Domain|compound|END_ENTITY	Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine .
19800870	0	UHRF1	0,5	Tip60	45,50	UHRF1	Tip60	29128	10524	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity .
22411829	0	UHRF1	52,57	USP7	117,121	UHRF1	USP7	29128	7874	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability .
23982143	0	UHRF1	14,19	miR-146a	23,31	UHRF1	miR-146a	29128	406938	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of UHRF1 by miR-146a / b modulates gastric_cancer invasion and metastasis .
20074931	0	UHRF1	172,177	p73	145,148	UHRF1	p73	29128	7161	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic_leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1 .
23833190	0	UHRF2	20,25	E2F1	73,77	UHRF2	E2F1	115426	1869	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The nuclear protein UHRF2 is a direct target of the transcription factor E2F1 in the induction of apoptosis .
21637656	0	UL1	34,37	UL7	46,49	UL1	UL7	8223388(Tax:72150)	8223381(Tax:72150)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Comparative analysis of the genes UL1 through UL7 of the duck_enteritis_virus and other herpesviruses of the subfamily Alphaherpesvirinae .
22479537	0	UL114	92,97	SMARCB1	32,39	UL114	SMARCB1	3077539(Tax:10359)	6598	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	The chromatin remodeling factor SMARCB1 forms a complex with human_cytomegalovirus proteins UL114 and UL44 .
12134014	0	UL12	66,70	US11	32,36	UL12	US11	24271463	2703439(Tax:10298)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|protein protein|compound|END_ENTITY	The herpes_simplex_virus_type_1 US11 protein binds the coterminal UL12 , UL13 , and UL14 RNAs and regulates UL13 expression in vivo .
17035316	0	UL15	106,110	UL28	84,88	UL15	UL28	2703385(Tax:10298)	2703457(Tax:10298)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	Linker insertion mutations in the herpes_simplex_virus_type_1 UL28 gene : effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation .
16342232	0	UL16_binding_protein-1	31,53	NKG2D	18,23	UL16 binding protein-1	NKG2D	80329	22914	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the NKG2D ligand UL16_binding_protein-1 -LRB- ULBP-1 -RRB- on dendritic cells .
12390682	0	UL18	160,164	LIR-1	61,66	UL18	LIR-1	3077466(Tax:10359)	10859	Gene	Gene	homolog|dobj|START_ENTITY MHC|xcomp|homolog the|acl:relcl|MHC implicated|nmod|the regions|acl|implicated END_ENTITY|nmod|regions	Crystal structure of LIR-2 -LRB- ILT4 -RRB- at 1.8 A : differences from LIR-1 -LRB- ILT2 -RRB- in regions implicated in the binding of the Human_Cytomegalovirus class I MHC homolog UL18 .
17372005	0	UL18	46,50	LIR-1	60,65	UL18	LIR-1	3077466(Tax:10359)	10859	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	The human_cytomegalovirus MHC class I homolog UL18 inhibits LIR-1 + but activates LIR-1 - NK cells .
17346762	0	UL24	15,19	nucleolin	67,76	UL24	nucleolin	24271468	4691	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin .
18420791	0	UL24	58,62	nucleolin	125,134	UL24	nucleolin	24271468	4691	Gene	Gene	protein|compound|START_ENTITY domain|nmod|protein sufficient|nsubj|domain sufficient|xcomp|induce induce|dobj|redistribution redistribution|nmod|END_ENTITY	The conserved N-terminal domain of herpes_simplex_virus_1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin .
19864385	0	UL24	26,30	nucleolin	118,127	UL24	nucleolin	24271468	4691	Gene	Gene	protein|compound|START_ENTITY residues|nmod|protein important|nsubj|residues important|nmod|dispersal dispersal|nmod|END_ENTITY	Conserved residues in the UL24 protein of herpes_simplex_virus_1 are important for dispersal of the nucleolar protein nucleolin .
17035316	0	UL28	84,88	UL15	106,110	UL28	UL15	2703457(Tax:10298)	2703385(Tax:10298)	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	Linker insertion mutations in the herpes_simplex_virus_type_1 UL28 gene : effects on UL28 interaction with UL15 and UL33 and identification of a second-site mutation in the UL15 gene that suppresses a lethal UL28 mutation .
11005871	0	UL31	37,41	UL34	118,122	UL31	UL34	2703350(Tax:10298)	2703355(Tax:10298)	Gene	Gene	gene|compound|START_ENTITY encoded|nmod|gene protein|acl|encoded depends|nsubj|protein depends|nmod|presence presence|nmod|protein protein|compound|END_ENTITY	The essential protein encoded by the UL31 gene of herpes_simplex_virus_1 depends for its stability on the presence of UL34 protein .
15476875	0	UL31	161,165	UL34	111,115	UL31	UL34	2703350(Tax:10298)	2703355(Tax:10298)	Gene	Gene	absence|nmod|START_ENTITY rim|nmod|absence target|nmod|rim target|dobj|protein protein|compound|END_ENTITY	Cell lines that support replication of a novel herpes_simplex_virus_1 UL31 deletion mutant can properly target UL34 protein to the nuclear rim in the absence of UL31 .
15476875	0	UL31	70,74	UL34	111,115	UL31	UL34	2703350(Tax:10298)	2703355(Tax:10298)	Gene	Gene	mutant|compound|START_ENTITY replication|nmod|mutant support|dobj|replication lines|acl:relcl|support target|nsubj|lines target|dobj|protein protein|compound|END_ENTITY	Cell lines that support replication of a novel herpes_simplex_virus_1 UL31 deletion mutant can properly target UL34 protein to the nuclear rim in the absence of UL31 .
15731273	0	UL31	131,135	UL34	68,72	UL31	UL34	2703350(Tax:10298)	2703355(Tax:10298)	Gene	Gene	protein|compound|START_ENTITY interact|nmod|protein necessary|xcomp|interact protein|acl:relcl|necessary protein|compound|END_ENTITY	Identification of an essential domain in the herpes_simplex_virus_1 UL34 protein that is necessary and sufficient to interact with UL31 protein .
25036476	0	UL31	38,42	UL34	63,67	UL31	UL34	2703350(Tax:10298)	2703355(Tax:10298)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	HSV-1 nucleocapsid egress mediated by UL31 in association with UL34 is impeded by cellular transmembrane_protein_140 .
11005871	0	UL34	118,122	UL31	37,41	UL34	UL31	2703355(Tax:10298)	2703350(Tax:10298)	Gene	Gene	protein|compound|START_ENTITY presence|nmod|protein depends|nmod|presence depends|nsubj|protein protein|acl|encoded encoded|nmod|gene gene|compound|END_ENTITY	The essential protein encoded by the UL31 gene of herpes_simplex_virus_1 depends for its stability on the presence of UL34 protein .
15476875	0	UL34	111,115	UL31	161,165	UL34	UL31	2703355(Tax:10298)	2703350(Tax:10298)	Gene	Gene	protein|compound|START_ENTITY target|dobj|protein target|nmod|rim rim|nmod|absence absence|nmod|END_ENTITY	Cell lines that support replication of a novel herpes_simplex_virus_1 UL31 deletion mutant can properly target UL34 protein to the nuclear rim in the absence of UL31 .
15476875	0	UL34	111,115	UL31	70,74	UL34	UL31	2703355(Tax:10298)	2703350(Tax:10298)	Gene	Gene	protein|compound|START_ENTITY target|dobj|protein target|nsubj|lines lines|acl:relcl|support support|dobj|replication replication|nmod|mutant mutant|compound|END_ENTITY	Cell lines that support replication of a novel herpes_simplex_virus_1 UL31 deletion mutant can properly target UL34 protein to the nuclear rim in the absence of UL31 .
15731273	0	UL34	68,72	UL31	131,135	UL34	UL31	2703355(Tax:10298)	2703350(Tax:10298)	Gene	Gene	protein|compound|START_ENTITY protein|acl:relcl|necessary necessary|xcomp|interact interact|nmod|protein protein|compound|END_ENTITY	Identification of an essential domain in the herpes_simplex_virus_1 UL34 protein that is necessary and sufficient to interact with UL31 protein .
25036476	0	UL34	63,67	UL31	38,42	UL34	UL31	2703355(Tax:10298)	2703350(Tax:10298)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	HSV-1 nucleocapsid egress mediated by UL31 in association with UL34 is impeded by cellular transmembrane_protein_140 .
20444996	0	UL44	108,112	IRS1	46,50	UL44	IRS1	3077460(Tax:10359)	3077574(Tax:10359)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human_cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44 .
20538862	0	UL44	55,59	p84	46,49	UL44	p84	3077460(Tax:10359)	9984	Gene	Gene	DNA|compound|START_ENTITY END_ENTITY|nmod|DNA	Role of the specific interaction of UL112-113 p84 with UL44 DNA polymerase processivity factor in promoting DNA replication of human_cytomegalovirus .
18353951	0	UL56	28,32	Nedd4	69,74	UL56	Nedd4	1487345(Tax:10310)	4734	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Herpes_simplex_virus_type_2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination .
19835589	0	UL56	45,49	Nedd4	79,84	UL56	Nedd4	1487345(Tax:10310)	4734	Gene	Gene	relocalizes|nsubj|START_ENTITY relocalizes|dobj|END_ENTITY	Herpes_simplex_virus_type_2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions .
16478985	0	UL69	4,8	UAP56	96,101	UL69	UAP56	3077554(Tax:10359)	7919	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The UL69 transactivator protein of human_cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA .
21637656	0	UL7	46,49	UL1	34,37	UL7	UL1	8223381(Tax:72150)	8223388(Tax:72150)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Comparative analysis of the genes UL1 through UL7 of the duck_enteritis_virus and other herpesviruses of the subfamily Alphaherpesvirinae .
15246266	0	UL72	47,51	dUTPase	77,84	UL72	dUTPase	3077454(Tax:10359)	34529(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nsubj|protein	Evidence that the human_cytomegalovirus 46-kDa UL72 protein is not an active dUTPase but a late protein dispensable for replication in fibroblasts .
25218028	0	ULBP-1	65,71	COX-2	0,5	ULBP-1	COX-2	80329	4513	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	COX-2 - and endoplasmic reticulum stress-independent induction of ULBP-1 and enhancement of sensitivity to NK cell-mediated cytotoxicity by celecoxib in colon_cancer cells .
18706445	0	ULBP2	15,20	IL-18	0,5	ULBP2	IL-18	80328	3606	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells .
22754777	0	ULBP2	26,31	NKG2D	92,97	ULBP2	NKG2D	80328	22914	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Tumor suppressors control ULBP2 , an innate surface ligand of the lymphocyte immune receptor NKG2D .
25266655	0	ULK1	92,96	14-3-3	117,123	ULK1	14-3-3	8408	10971	Gene	Gene	Interaction|amod|START_ENTITY Interaction|amod|END_ENTITY	Metabolic-Stress-Induced Rearrangement of the 14-3-3 Interactome Promotes Autophagy via a ULK1 - and AMPK-Regulated 14-3-3 Interaction with Phosphorylated Atg9 .
24119841	0	ULK1	29,33	ATG1	35,39	ULK1	ATG1	8408	8408	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Cyclic_dinucleotides trigger ULK1 -LRB- ATG1 -RRB- phosphorylation of STING to prevent sustained innate immune signaling .
23817237	0	ULK1	0,4	Beclin-1	13,21	ULK1	Beclin-1	8408	8678	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	ULK1 targets Beclin-1 in autophagy .
26986052	0	ULK1	18,22	GABARAP	0,7	ULK1	GABARAP	8408	11337	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	GABARAP activates ULK1 and traffics from the centrosome dependent on Golgi partners WAC and GOLGA2/GM130 .
21795849	0	ULK1	0,4	mTORC1	37,43	ULK1	mTORC1	8408	382056(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	ULK1 inhibits the kinase activity of mTORC1 and cell proliferation .
25909887	0	ULK1	37,41	p32	23,26	ULK1	p32	8408	708	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Chaperone-like protein p32 regulates ULK1 stability and autophagy .
26001217	0	ULK1	37,41	p32	23,26	ULK1	p32	8408	708	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Chaperone-like protein p32 regulates ULK1 stability and autophagy .
26920049	0	ULK2	40,44	miR-26b	0,7	ULK2	miR-26b	9706	407017	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-26b inhibits autophagy by targeting ULK2 in prostate_cancer cells .
8382593	0	UMOD	47,51	uromodulin	30,40	UMOD	uromodulin	7369	7369	Gene	Gene	assignment|appos|START_ENTITY assignment|nmod|gene gene|compound|END_ENTITY	Chromosomal assignment of the uromodulin gene -LRB- UMOD -RRB- to 16p13 .11 .
18535602	0	UMODL1	77,83	uromodulin-like_1	58,75	UMODL1	uromodulin-like 1	89766	89766	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	New susceptibility locus for high_myopia is linked to the uromodulin-like_1 -LRB- UMODL1 -RRB- gene region on chromosome 21q22 .3 .
10397769	0	UNC-11	0,6	AP180	33,38	UNC-11	AP180	171952(Tax:6239)	9892	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	UNC-11 , a Caenorhabditis_elegans AP180 homologue , regulates the size and protein composition of synaptic vesicles .
21937599	0	UNC-116	74,81	MIG-15	0,6	UNC-116	MIG-15	176179(Tax:6239)	181248(Tax:6239)	Gene	Gene	promote|nmod|START_ENTITY promote|nsubj|END_ENTITY	MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1 .
19169249	0	UNC-129	0,7	UNC-5	71,76	UNC-129	UNC-5	177719(Tax:6239)	177334(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways .
11460165	0	UNC-13	54,60	syntaxin	16,24	UNC-13	syntaxin	172497(Tax:6239)	172663(Tax:6239)	Gene	Gene	requirement|nmod|START_ENTITY bypasses|dobj|requirement bypasses|nsubj|form form|nmod|END_ENTITY	An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming .
16271476	0	UNC-13	0,6	syntaxin	24,32	UNC-13	syntaxin	172497(Tax:6239)	172663(Tax:6239)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	UNC-13 interaction with syntaxin is required for synaptic transmission .
26435886	0	UNC-23	15,21	HSP-1	128,133	UNC-23	HSP-1	179272(Tax:6239)	178507(Tax:6239)	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The C. _ elegans UNC-23 protein , a member of the BCL-2-associated athanogene -LRB- BAG -RRB- family of chaperone regulators , interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity .
20431118	0	UNC-37	21,27	LSY-22	74,80	UNC-37	LSY-22	172394(Tax:6239)	172536(Tax:6239)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Groucho ortholog UNC-37 interacts with the short Groucho-like protein LSY-22 to control developmental decisions in C. _ elegans .
15282156	0	UNC-39	0,6	Six5	94,98	UNC-39	Six5	191623(Tax:6239)	147912	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	UNC-39 , the C. _ elegans homolog of the human myotonic_dystrophy-associated homeodomain protein Six5 , regulates cell motility and differentiation .
25122090	0	UNC-40	22,28	EVA-1	0,5	UNC-40	EVA-1	172233(Tax:6239)	173355(Tax:6239)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis_elegans .
20627077	0	UNC-40	64,70	MADD-2	29,35	UNC-40	MADD-2	172233(Tax:6239)	178619(Tax:6239)	Gene	Gene	motif|nmod|START_ENTITY motif|dobj|functions functions|compound|END_ENTITY	The tripartite motif protein MADD-2 functions with the receptor UNC-40 -LRB- DCC -RRB- in Netrin-mediated axon attraction and branching .
20627078	0	UNC-40	96,102	MADD-2	0,6	UNC-40	MADD-2	172233(Tax:6239)	178619(Tax:6239)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MADD-2 , a homolog of the Opitz_syndrome protein MID1 , regulates guidance to the midline through UNC-40 in Caenorhabditis_elegans .
18190904	0	UNC-45	0,6	NMY-2	23,28	UNC-45	NMY-2	175206(Tax:6239)	172562(Tax:6239)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|compound|END_ENTITY	UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. _ elegans .
26292279	0	UNC-5	46,51	MOM-5	26,31	UNC-5	MOM-5	177334(Tax:6239)	172856(Tax:6239)	Gene	Gene	Receptor|compound|START_ENTITY Regulates|dobj|Receptor Regulates|nsubj|END_ENTITY	The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells .
26292279	0	UNC-5	46,51	MOM-5	26,31	UNC-5	MOM-5	177334(Tax:6239)	172856(Tax:6239)	Gene	Gene	Receptor|compound|START_ENTITY Regulates|dobj|Receptor Regulates|nsubj|END_ENTITY	The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells .
16024786	0	UNC-5	15,20	SRC-1	0,5	UNC-5	SRC-1	177334(Tax:6239)	171722(Tax:6239)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	SRC-1 mediates UNC-5 signaling in Caenorhabditis_elegans .
19169249	0	UNC-5	71,76	UNC-129	0,7	UNC-5	UNC-129	177334(Tax:6239)	177719(Tax:6239)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways .
10980252	0	UNC-50	33,39	UNCL	0,4	UNC-50	UNCL	25972	25972	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	UNCL , the mammalian homologue of UNC-50 , is an inner nuclear membrane RNA-binding protein .
15539493	0	UNC-51	21,27	VAB-8	38,43	UNC-51	VAB-8	180311(Tax:6239)	179675(Tax:6239)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. _ elegans .
20643644	0	UNC-51-like_kinase_3	17,37	Ulk3	39,43	UNC-51-like kinase 3	Ulk3	25989	25989	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Dual function of UNC-51-like_kinase_3 -LRB- Ulk3 -RRB- in the Sonic_hedgehog signaling pathway .
21186357	0	UNC-6	0,5	PAR-4	50,55	UNC-6	PAR-4	180961(Tax:6239)	180185(Tax:6239)	Gene	Gene	promote|nsubj|START_ENTITY promote|nmod|END_ENTITY	UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis_elegans neurons .
21338947	0	UNC-6	24,29	TRIM-9	0,6	UNC-6	TRIM-9	180961(Tax:6239)	34453(Tax:7227)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	TRIM-9 functions in the UNC-6 / UNC-40 pathway to regulate ventral guidance .
16725058	0	UNC-69	48,54	UNC-76	71,77	UNC-69	UNC-76	176444(Tax:6239)	180014(Tax:6239)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis_elegans .
16725058	0	UNC-76	71,77	UNC-69	48,54	UNC-76	UNC-69	180014(Tax:6239)	176444(Tax:6239)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis_elegans .
12953066	0	UNC-78	93,99	Actin	0,5	UNC-78	Actin	180631(Tax:6239)	176793(Tax:6239)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Actin filament disassembling activity of Caenorhabditis_elegans actin-interacting_protein_1 -LRB- UNC-78 -RRB- is dependent on filament binding by a specific ADF/cofilin isoform .
15150269	0	UNC-78	93,99	actin	120,125	UNC-78	actin	180631(Tax:6239)	176793(Tax:6239)	Gene	Gene	Identification|appos|START_ENTITY Identification|nmod|disassembly disassembly|nmod|END_ENTITY	Identification of functional residues on Caenorhabditis_elegans actin-interacting_protein_1 -LRB- UNC-78 -RRB- for disassembly of actin depolymerizing factor/cofilin-bound actin filaments .
15150269	0	UNC-78	93,99	actin	162,167	UNC-78	actin	180631(Tax:6239)	176793(Tax:6239)	Gene	Gene	Identification|appos|START_ENTITY Identification|nmod|disassembly disassembly|nmod|actin actin|acl|depolymerizing depolymerizing|dobj|END_ENTITY	Identification of functional residues on Caenorhabditis_elegans actin-interacting_protein_1 -LRB- UNC-78 -RRB- for disassembly of actin depolymerizing factor/cofilin-bound actin filaments .
12135927	0	UNC-86	47,53	tph-1	68,73	UNC-86	tph-1	176157(Tax:6239)	174227(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	The C. _ elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons .
22621901	0	UNC-89	0,6	MEL-26	27,33	UNC-89	MEL-26	171990(Tax:6239)	172737(Tax:6239)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	UNC-89 -LRB- obscurin -RRB- binds to MEL-26 , a BTB-domain protein , and affects the function of MEI-1 -LRB- katanin -RRB- in striated muscle of Caenorhabditis_elegans .
17174953	0	UNC119	40,46	HRG4	34,38	UNC119	HRG4	22248(Tax:10090)	22248(Tax:10090)	Gene	Gene	inactivation|appos|START_ENTITY inactivation|nmod|END_ENTITY	Targeted inactivation of synaptic HRG4 -LRB- UNC119 -RRB- causes dysfunction in the distal photoreceptor and slow retinal_degeneration , revealing a new function .
18385318	0	UNC5	159,163	SAX-3	138,143	UNC5	SAX-3	177334(Tax:6239)	180637(Tax:6239)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	RPM-1 , a Caenorhabditis_elegans protein that functions in presynaptic differentiation , negatively regulates axon outgrowth by controlling SAX-3 / robo and UNC-5 / UNC5 activity .
17995930	0	UNC5A	137,142	netrin-1	90,98	UNC5A	netrin-1	90249	9423	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Netrin-1-independent adenosine A2b receptor activation regulates the response of axons to netrin-1 by controlling cell surface levels of UNC5A receptors .
17908930	0	UNC5B	18,23	Netrin-1	36,44	UNC5B	Netrin-1	219699	9423	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis .
19826074	0	UNC5B	62,67	netrin-1	35,43	UNC5B	netrin-1	219699	9423	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization and expression of netrin-1 and its receptors UNC5B and DCC in human placenta .
24518784	0	UNC5D	19,24	UNC5D	44,49	UNC5D	UNC5D	137970	137970	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|dep|END_ENTITY	Down-regulation of UNC5D in bladder_cancer : UNC5D as a possible mediator of cisplatin induced apoptosis in bladder_cancer cells .
24518784	0	UNC5D	44,49	UNC5D	19,24	UNC5D	UNC5D	137970	137970	Gene	Gene	Down-regulation|dep|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of UNC5D in bladder_cancer : UNC5D as a possible mediator of cisplatin induced apoptosis in bladder_cancer cells .
15729359	0	UNC5H2	24,30	DAP-kinase	58,68	UNC5H2	DAP-kinase	107449(Tax:10090)	69635(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase .
19755150	0	UNC5a	92,97	RhoA	53,57	UNC5a	RhoA	107448(Tax:10090)	11848(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth .
10980252	0	UNCL	0,4	UNC-50	33,39	UNCL	UNC-50	25972	25972	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	UNCL , the mammalian homologue of UNC-50 , is an inner nuclear membrane RNA-binding protein .
21804017	0	UNG	13,16	AID	0,3	UNG	AID	22256(Tax:10090)	11628(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus -LSB- corrected -RSB- .
11104908	0	UNG	56,59	uracil-DNA_glycosylase	32,54	UNG	uracil-DNA glycosylase	7374	7374	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence variation in the human uracil-DNA_glycosylase -LRB- UNG -RRB- gene .
19411194	0	UNG	108,111	uracil-DNA_glycosylase	84,106	UNG	uracil-DNA glycosylase	7374	7374	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA_glycosylase -LRB- UNG -RRB- gene through a mechanism involving derepression .
7819187	0	UNG	66,69	uracil-DNA_glycosylase	34,56	UNG	uracil-DNA glycosylase	7374	7374	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Properties of a recombinant human uracil-DNA_glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA_glycosylase .
11571651	0	UNP	15,18	pRb	76,79	UNP	pRb	22258(Tax:10090)	19645(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of UNP , a ubiquitin-specific protease , with the pocket proteins pRb , p107 and p130 .
20967855	0	UPAR	58,62	CD87	64,68	UPAR	CD87	5329	5329	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A genetic variation located in the promoter region of the UPAR -LRB- CD87 -RRB- gene is associated with the vascular complications of systemic_sclerosis .
23238479	0	UPB1	40,44	b-ureidopropionase	20,38	UPB1	b-ureidopropionase	51733	51733	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Contribution of the b-ureidopropionase -LRB- UPB1 -RRB- gene alterations to the development of fluoropyrimidine-related toxicity .
20691628	0	UPF1	0,4	CBP80	47,52	UPF1	CBP80	5976	4686	Gene	Gene	association|nummod|START_ENTITY association|nmod|END_ENTITY	UPF1 association with the cap-binding_protein , CBP80 , promotes nonsense-mediated mRNA decay at two distinct steps .
25775514	0	UPF1	85,89	Glucocorticoid_receptor	0,23	UPF1	Glucocorticoid receptor	5976	2908	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Glucocorticoid_receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation .
26759305	0	UPF1	34,38	Smad7	76,81	UPF1	Smad7	5976	4092	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular_carcinoma .
21829167	0	UPF1	6,10	TPP1	26,30	UPF1	TPP1	5976	1200	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication .
23708980	0	UQCRB	14,19	VEGFR2	30,36	UQCRB	VEGFR2	7381	3791	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells .
15304510	0	URAT1	112,117	PDZK1	46,51	URAT1	PDZK1	116085	5174	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus .
16837472	0	URAT1	36,41	SLC22A12	26,34	URAT1	SLC22A12	116085	116085	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular analysis of the SLC22A12 -LRB- URAT1 -RRB- gene in patients with primary_gout .
16703794	0	URAT1	50,55	urate_transporter_1	29,48	URAT1	urate transporter 1	116085	116085	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Analysis of mutations in the urate_transporter_1 -LRB- URAT1 -RRB- gene of Japanese patients with hypouricemia in northern Japan and review of the literature .
26657209	0	URG-4	74,79	TGF-b1	55,61	URG-4	TGF-b1	55665	7040	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Identification of intracellular pathways through which TGF-b1 upregulates URG-4 / URGCP gene expression in hepatoma cells .
26657209	0	URG-4	74,79	URGCP	80,85	URG-4	URGCP	55665	55665	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Identification of intracellular pathways through which TGF-b1 upregulates URG-4 / URGCP gene expression in hepatoma cells .
26657209	0	URGCP	80,85	TGF-b1	55,61	URGCP	TGF-b1	55665	7040	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Identification of intracellular pathways through which TGF-b1 upregulates URG-4 / URGCP gene expression in hepatoma cells .
26657209	0	URGCP	80,85	URG-4	74,79	URGCP	URG-4	55665	55665	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Identification of intracellular pathways through which TGF-b1 upregulates URG-4 / URGCP gene expression in hepatoma cells .
10226592	0	URIM	18,22	up-regulated_in_metastasis	37,63	URIM	up-regulated in metastasis	64976	64976	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of URIM , a novel gene up-regulated_in_metastasis .
11929044	0	URO-D	42,47	uroporphyrinogen_decarboxylase	10,40	URO-D	uroporphyrinogen decarboxylase	7389	7389	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of uroporphyrinogen_decarboxylase -LRB- URO-D -RRB- in erythrocytes of Italian porphyria cutanea tarda patients .
11295834	0	UROD	67,71	uroporphyrinogen_decarboxylase	35,65	UROD	uroporphyrinogen decarboxylase	7389	7389	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Seven novel point mutations in the uroporphyrinogen_decarboxylase -LRB- UROD -RRB- gene in patients with familial_porphyria_cutanea_tarda -LRB- f-PCT -RRB- .
16026339	0	UROD	74,78	uroporphyrinogen_decarboxylase	42,72	UROD	uroporphyrinogen decarboxylase	100514239	100514239	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of a mutation in the ovine uroporphyrinogen_decarboxylase -LRB- UROD -RRB- gene associated with a type of porphyria .
2037278	0	UROS	64,68	uroporphyrinogen_III_synthase	33,62	UROS	uroporphyrinogen III synthase	7390	7390	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regional assignment of the human uroporphyrinogen_III_synthase -LRB- UROS -RRB- gene to chromosome 10q25 .2 -- q26 .3 .
23275732	0	UROS	56,60	uroporphyrinogen_III_synthase	25,54	UROS	uroporphyrinogen III synthase	7390	7390	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phylogenetic analysis of uroporphyrinogen_III_synthase -LRB- UROS -RRB- gene .
22433941	0	URP	75,78	urotensin_II-related_peptide	45,73	URP	urotensin II-related peptide	100001008(Tax:7955)	100001008(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the true ortholog of the urotensin_II-related_peptide -LRB- URP -RRB- gene in teleosts .
18280249	0	URP2SF	0,6	NF-kappaB	59,68	URP2SF	NF-kappaB	83706	4790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	URP2SF , a FERM and PH domain containing protein , regulates NF-kappaB and apoptosis .
25712217	0	US1	30,33	IFN-b	43,48	US1	IFN-b	1487350(Tax:10310)	3456	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	HSV-2 immediate-early protein US1 inhibits IFN-b production by suppressing association of IRF-3 with IFN-b promoter .
14990717	0	US11	0,4	HIPK2	51,56	US11	HIPK2	2703439(Tax:10298)	28996	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	US11 of herpes_simplex_virus_type_1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest .
16414996	0	US12	66,70	US17	44,48	US12	US17	3077562(Tax:10359)	3077567(Tax:10359)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Infection-dependent nuclear localization of US17 , a member of the US12 family of human_cytomegalovirus-encoded seven-transmembrane proteins .
16414996	0	US17	44,48	US12	66,70	US17	US12	3077567(Tax:10359)	3077562(Tax:10359)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Infection-dependent nuclear localization of US17 , a member of the US12 family of human_cytomegalovirus-encoded seven-transmembrane proteins .
15254210	0	US28	57,61	Galpha12	108,116	US28	Galpha12	3077536(Tax:10359)	2768	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Human_cytomegalovirus-encoded G protein-coupled receptor US28 mediates smooth_muscle_cell migration through Galpha12 .
19318580	0	US28	53,57	cyclooxygenase-2	104,120	US28	cyclooxygenase-2	3077536(Tax:10359)	5743	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|angiogenesis angiogenesis|nmod|END_ENTITY	The human_cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2 .
25878107	0	US3	23,26	KIF3A	51,56	US3	KIF3A	2703401(Tax:10298)	11127	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Herpes_simplex_virus-1 US3 phosphorylates cellular KIF3A to down-regulate CD1d expression .
25878107	0	US3	23,26	KIF3A	51,56	US3	KIF3A	2703401(Tax:10298)	11127	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Herpes_simplex_virus-1 US3 phosphorylates cellular KIF3A to down-regulate CD1d expression .
12477250	0	US3	65,68	cytokeratin_17	19,33	US3	cytokeratin 17	1487355(Tax:10310)	3872	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Phosphorylation of cytokeratin_17 by herpes_simplex_virus_type_2 US3 protein kinase .
11157746	0	US6	39,42	TAP	67,70	US6	TAP	3077555(Tax:10359)	6890	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|binding binding|nmod|END_ENTITY	The human_cytomegalovirus gene product US6 inhibits ATP binding by TAP .
17389776	0	USAG-1	55,61	uterine_sensitization-associated_gene-1	14,53	USAG-1	uterine sensitization-associated gene-1	66042(Tax:10090)	66042(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of uterine_sensitization-associated_gene-1 -LRB- USAG-1 -RRB- in the mouse uterus during the peri-implantation period .
12163028	0	USF	23,26	HGF	30,33	USF	HGF	7391	3082	Gene	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	A critical function of USF in HGF gene regulation mediated by a multiconsensus region .
8486371	0	USF	63,66	upstream_stimulatory_factor	34,61	USF	upstream stimulatory factor	7391	7391	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the gene-encoding upstream_stimulatory_factor -LRB- USF -RRB- to human chromosome 1q22-q23 .
17289164	0	USF-1	63,68	upstream_stimulating_factor	34,61	USF-1	upstream stimulating factor	7391	7391	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|expression expression|nmod|END_ENTITY	Regulation of IL-10 expression by upstream_stimulating_factor -LRB- USF-1 -RRB- in glioma-associated microglia .
26297580	0	USF1	58,62	BRLF1	49,54	USF1	BRLF1	7391	17494186	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of Epstein-Barr_virus BRLF1 by USF1 and Rta .
12917334	0	USF1	0,4	Mash-2	99,105	USF1	Mash-2	7391	430	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|END_ENTITY	USF1 and USF2 mediate inhibition of human trophoblast differentiation and CYP19 gene expression by Mash-2 and hypoxia .
12576297	0	USF1	92,96	USF2	21,25	USF1	USF2	100009324(Tax:9986)	100008893(Tax:9986)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Transcription factor USF2 is developmentally regulated in fetal lung and acts together with USF1 to induce SP-A gene expression .
20031629	0	USF1	49,53	insulin	28,35	USF1	insulin	7391	3630	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Functional variant disrupts insulin induction of USF1 : mechanism for USF1-associated dyslipidemias .
24831529	0	USF1	31,35	p53	0,3	USF1	p53	22278(Tax:10090)	22060(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	p53 requires the stress sensor USF1 to direct appropriate cell fate decision .
12576297	0	USF2	21,25	USF1	92,96	USF2	USF1	100008893(Tax:9986)	100009324(Tax:9986)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Transcription factor USF2 is developmentally regulated in fetal lung and acts together with USF1 to induce SP-A gene expression .
15325563	0	USH2A	31,36	Usher_syndrome_type_II	45,67	USH2A	Usher syndrome type II	7399	7399	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Comprehensive screening of the USH2A gene in Usher_syndrome_type_II and non-syndromic recessive retinitis pigmentosa .
25572244	0	USH2C	24,29	GPR98	31,36	USH2C	GPR98	84059	84059	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel mutation of the USH2C -LRB- GPR98 -RRB- gene in an Iranian family with Usher_syndrome_type_II .
15671307	0	USH2C	68,73	VLGR1	47,52	USH2C	VLGR1	84059	84059	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Disease expression in Usher_syndrome caused by VLGR1 gene mutation -LRB- USH2C -RRB- and comparison with USH2A phenotype .
25753661	0	USIP-1	32,38	SART3	49,54	USIP-1	SART3	179670(Tax:6239)	178053(Tax:6239)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling .
22426999	0	USP1	0,4	AKT	15,18	USP1	AKT	7398	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung_cancer cells .
22439892	0	USP1	33,37	USP1-associated_factor_1	85,109	USP1	USP1-associated factor 1	7398	57599	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated_factor_1 .
22439892	0	USP1-associated_factor_1	85,109	USP1	33,37	USP1-associated factor 1	USP1	57599	7398	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	A noncanonical cysteine protease USP1 is activated through active site modulation by USP1-associated_factor_1 .
11439350	0	USP10	60,65	Ras-GAP_SH3_domain_binding_protein	0,34	USP10	Ras-GAP SH3 domain binding protein	9100	10146	Gene	Gene	modulator|nmod|START_ENTITY modulator|nsubj|END_ENTITY	Ras-GAP_SH3_domain_binding_protein -LRB- G3BP -RRB- is a modulator of USP10 , a novel human ubiquitin specific protease .
17897950	0	USP11	28,33	IkappaB_kinase_alpha	46,66	USP11	IkappaB kinase alpha	8237	1147	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	The deubiquitinating enzyme USP11 controls an IkappaB_kinase_alpha -LRB- IKKalpha -RRB- - p53 signaling pathway in response to tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- .
22773947	0	USP11	0,5	TGFb	15,19	USP11	TGFb	8237	7040	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|END_ENTITY	USP11 augments TGFb signalling by deubiquitylating ALK5 .
20147737	0	USP12	32,37	UAF1	40,44	USP12	UAF1	219333	57599	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex .
24145035	0	USP12	55,60	WDR48	18,23	USP12	WDR48	219333	57599	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH_domain_leucine-rich_repeat_protein_phosphatase_1 -LRB- PHLPP1 -RRB- .
19135427	0	USP14	0,5	IRE1alpha	62,71	USP14	IRE1alpha	9097	2081	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	USP14 inhibits ER-associated degradation via interaction with IRE1alpha .
24777531	0	USP15	0,5	MDM2	17,21	USP15	MDM2	9958	4193	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses .
23727018	0	USP15	0,5	Nrf2	27,31	USP15	Nrf2	9958	4780	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	USP15 negatively regulates Nrf2 through deubiquitination of Keap1 .
23708518	0	USP15	19,24	REST	54,58	USP15	REST	9958	5978	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit .
26610488	0	USP17	19,24	IL-33	73,78	USP17	IL-33	391627	90865	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Function Function|nmod|END_ENTITY	The Deubiquitinase USP17 Regulates the Stability and Nuclear Function of IL-33 .
18941237	0	USP18	128,133	UBP43	121,126	USP18	UBP43	11274	11274	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The level of hepatitis_B virus replication is not affected by protein ISG15 modification but is reduced by inhibition of UBP43 -LRB- USP18 -RRB- expression .
25981749	0	USP18	109,114	ubiquitin-specific_protease_18	77,107	USP18	ubiquitin-specific protease 18	100334535(Tax:7955)	100334535(Tax:7955)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Expression characterization , genomic structure and function analysis of fish ubiquitin-specific_protease_18 -LRB- USP18 -RRB- genes .
24561192	0	USP22	0,5	NFATc2	33,39	USP22	NFATc2	23326	4773	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	USP22 is a positive regulator of NFATc2 on promoting IL2 expression .
23159851	0	USP24	29,34	DDB2	50,54	USP24	DDB2	23358	1643	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability .
24286619	0	USP24	36,41	NF-kappa_B	61,71	USP24	NF-kappa B	23358	4790	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of human USP24 gene expression by NF-kappa_B .
20501646	0	USP26	28,33	androgen_receptor	52,69	USP26	androgen receptor	83844	367	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The deubiquitinating enzyme USP26 is a regulator of androgen_receptor signaling .
24075993	0	USP28	19,24	LSD1	36,40	USP28	LSD1	57646	23028	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast_cancer cells .
24196443	0	USP3	0,4	RNF168	17,23	USP3	RNF168	9960	165918	Gene	Gene	counteracts|nsubj|START_ENTITY counteracts|dobj|END_ENTITY	USP3 counteracts RNF168 via deubiquitinating H2A and yH2AX at lysine 13 and 15 .
15354349	0	USP31	60,65	ubiquitin_specific_protease_31	28,58	USP31	ubiquitin specific protease 31	84196	84196	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of the human ubiquitin_specific_protease_31 -LRB- USP31 -RRB- gene : structure , sequence and expression analysis .
21596315	0	USP37	15,20	CDK2	37,41	USP37	CDK2	57695	1017	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Deubiquitinase USP37 is activated by CDK2 to antagonize APC -LRB- CDH1 -RRB- and promote S phase entry .
26387952	0	USP4	28,32	CtIP	49,53	USP4	CtIP	7375	5932	Gene	Gene	Cooperates|compound|START_ENTITY Cooperates|nmod|END_ENTITY	The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Break End Resection .
21331078	0	USP4	0,4	TAK1	13,17	USP4	TAK1	7375	6885	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	USP4 targets TAK1 to downregulate TNFa-induced NF-kB activation .
21522127	0	USP4	0,4	p53	14,17	USP4	p53	22258(Tax:10090)	22060(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 .
26411366	0	USP4	0,4	p53	14,17	USP4	p53	7375	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	USP4 inhibits p53 and NF-kB through deubiquitinating and stabilizing HDAC2 .
22085928	0	USP42	72,77	p53	14,17	USP42	p53	84132	7157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|stability stability|compound|END_ENTITY	Regulation of p53 stability and function by the deubiquitinating enzyme USP42 .
20111060	0	USP46	54,59	ubiquitin-specific_peptidase_46	21,52	USP46	ubiquitin-specific peptidase 46	69727(Tax:10090)	69727(Tax:10090)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Association study of ubiquitin-specific_peptidase_46 -LRB- USP46 -RRB- with bipolar_disorder and schizophrenia in a Japanese population .
26175158	0	USP7	28,32	Androgen_Receptor	43,60	USP7	Androgen Receptor	7874	367	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Activity Activity|compound|END_ENTITY	The Deubiquitinating Enzyme USP7 Regulates Androgen_Receptor Activity by Modulating Its Binding to Chromatin .
18410486	0	USP7	91,95	MARCH7	24,30	USP7	MARCH7	7874	64844	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X .
25358258	0	USP7	33,37	MBD4	0,4	USP7	MBD4	7874	8930	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	MBD4 Interacts with and Recruits USP7 to heterochromatic foci .
25694600	0	USP7	91,95	ORF33	72,77	USP7	ORF33	7874	4961502(Tax:37296)	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	A survey of the interactome of KSHV ORF45 revealed its binding to viral ORF33 and cellular USP7 resulting in stabilization of ORF33 that is required for production of progeny viruses .
25634095	0	USP7	39,43	Polycomb	0,8	USP7	Polycomb	252870(Tax:10090)	12416(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis .
25605328	0	USP7	0,4	SCML2	21,26	USP7	SCML2	7874	10389	Gene	Gene	COOPERATES|nsubj|START_ENTITY COOPERATES|nmod|END_ENTITY	USP7 COOPERATES WITH SCML2 TO REGULATE THE ACTIVITY OF PRC1 .
25634095	0	USP7	39,43	SCML2	17,22	USP7	SCML2	252870(Tax:10090)	107815(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis .
22750444	0	USP7	16,20	STAT3	0,5	IL-6	STAT3	3569	6774	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	STAT3 repressed USP7 expression is crucial for colon_cancer development .
22411829	0	USP7	117,121	UHRF1	52,57	USP7	UHRF1	7874	29128	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability .
22466611	0	USP7	45,49	UVSSA	30,35	USP7	UVSSA	7874	57654	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	UV-sensitive_syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair .
12093161	0	USP7	0,4	ataxin-1	52,60	USP7	ataxin-1	252870(Tax:10090)	20238(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	USP7 , a ubiquitin-specific protease , interacts with ataxin-1 , the SCA1 gene product .
15254178	0	USP7	76,80	p53	67,70	USP7	p53	7874	7157	Gene	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	Herpes_simplex_virus_type_1 infection induces the stabilization of p53 in a USP7 - and ATM-independent manner .
21907705	0	USP9X	86,91	Mcl-1	29,34	USP9X	Mcl-1	8239	4170	Gene	Gene	interaction|compound|START_ENTITY regulation|nmod|interaction controls|nmod|regulation controls|dobj|ubiquitination ubiquitination|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
21907705	0	USP9X	86,91	Mcl-1	80,85	USP9X	Mcl-1	8239	4170	Gene	Gene	interaction|compound|START_ENTITY interaction|compound|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
23171055	0	USP9X	32,37	Mcl-1	22,27	USP9X	Mcl-1	8239	4170	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition .
24890815	0	USP9X	97,102	MicroRNA-26b	0,12	USP9X	MicroRNA-26b	8239	407017	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-26b inhibits epithelial-mesenchymal_transition in hepatocellular_carcinoma by targeting USP9X .
21907705	0	USP9X	86,91	Noxa	0,4	USP9X	Noxa	8239	5366	Gene	Gene	interaction|compound|START_ENTITY regulation|nmod|interaction controls|nmod|regulation controls|nsubj|END_ENTITY	Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1 / USP9X interaction .
23097624	0	USP9x	15,20	Mcl-1	70,75	USP9x	Mcl-1	8239	4170	Gene	Gene	confers|nsubj|START_ENTITY confers|nmod|stabilization stabilization|nmod|END_ENTITY	Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1 .
26717875	0	USP9x	26,31	b-catenin	0,9	USP9x	b-catenin	8239	1499	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	b-catenin is regulated by USP9x and mediates resistance to TRAIL-induced apoptosis in breast_cancer .
20410807	0	UTF1	72,76	NANOG	59,64	UTF1	NANOG	8433	79923	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	UTF1	72,76	OCT4	53,57	UTF1	OCT4	8433	5460	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	UTF1	72,76	SALL4	46,51	UTF1	SALL4	8433	57167	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
20410807	0	UTF1	72,76	SOX2	66,70	UTF1	SOX2	8433	6657	Gene	Gene	markers|nummod|START_ENTITY markers|nummod|END_ENTITY	Diagnostic utility of novel stem cell markers SALL4 , OCT4 , NANOG , SOX2 , UTF1 , and TCL1 in primary mediastinal germ cell tumors .
23333481	0	UTS-II	75,81	urotensin-II	61,73	UTS-II	urotensin-II	10911	10911	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Thr21Met -LRB- T21M -RRB- but not Ser89Asn -LRB- S89N -RRB- polymorphisms of the urotensin-II -LRB- UTS-II -RRB- gene are associated with Behcet 's _ disease -LRB- BD -RRB- .
22587369	0	UTS2	77,81	urotensin-II	63,75	UTS2	urotensin-II	10911	10911	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between Thr21Met and Ser89Asn polymorphisms of the urotensin-II -LRB- UTS2 -RRB- gene , diabetes_mellitus , and diabetic_retinopathy .
21559414	0	UTS2	43,47	urotensin_II	24,36	UTS2	urotensin II	10911	10911	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association analysis of urotensin_II gene -LRB- UTS2 -RRB- and flanking regions with biochemical parameters related to insulin resistance .
9632823	0	UV-damaged-DNA_binding_factor	16,45	p48	0,3	UV-damaged-DNA binding factor	p48	1642	10379	Gene	Gene	Activates|dobj|START_ENTITY Activates|nsubj|END_ENTITY	p48 Activates a UV-damaged-DNA_binding_factor and is defective in xeroderma_pigmentosum group E cells that lack binding activity .
22927934	0	UV-damaged_DNA_binding_protein_1	17,49	DDB1	51,55	UV-damaged DNA binding protein 1	DDB1	778355(Tax:4081)	778355(Tax:4081)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role of tomato UV-damaged_DNA_binding_protein_1 -LRB- DDB1 -RRB- in organ size control via an epigenetic manner .
24157211	0	UVH6	50,54	DDB1A	56,61	UVH6	DDB1A	839557(Tax:3702)	825890(Tax:3702)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Interactions between Arabidopsis DNA repair genes UVH6 , DDB1A , and DDB2 during abiotic stress tolerance and floral development .
24945150	0	UVI4	47,51	CPR5	15,19	UVI4	CPR5	818827(Tax:3702)	836617(Tax:3702)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of CPR5 with cell cycle regulators UVI4 and OSD1 in Arabidopsis .
17891140	0	UVRAG	38,43	Bif-1	0,5	UVRAG	Bif-1	7405	51100	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Bif-1 interacts with Beclin_1 through UVRAG and regulates autophagy and tumorigenesis .
22466611	0	UVSSA	30,35	USP7	45,49	UVSSA	USP7	57654	7874	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	UV-sensitive_syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair .
17635584	0	UXT	0,3	EVI1	57,61	UXT	EVI1	8409	2122	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	UXT interacts with the transcriptional repressor protein EVI1 and suppresses cell transformation .
23603909	0	UbE2E1	77,83	Ubiquitin-specific_protease_7	0,29	UbE2E1	Ubiquitin-specific protease 7	7324	7874	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Ubiquitin-specific_protease_7 is a regulator of ubiquitin-conjugating enzyme UbE2E1 .
17942533	0	Ubc13	97,102	NF-kappaB	107,116	Ubc13	NF-kappaB	7334	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	The human T-cell_leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation .
20472056	0	Ubc13	20,25	TNFR1	29,34	Ubc13	TNFR1	7334	7132	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	A novel function of Ubc13 in TNFR1 receptor activation .
16129784	0	Ubc13	23,28	ubiquitin-conjugating_enzyme	50,78	Ubc13	ubiquitin-conjugating enzyme	7334	7316	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating_enzyme variants Mms2 and Uev1A .
16631117	0	Ubc9	0,4	SOX4	20,24	Ubc9	SOX4	7329	6659	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ubc9 interacts with SOX4 and represses its transcriptional activity .
12813045	0	Ubc9	7,11	SUMO-1	0,6	Ubc9	SUMO-1	7329	7341	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	SUMO-1 / Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4 .
12813045	0	Ubc9	7,11	Smad4	86,91	Ubc9	Smad4	7329	4089	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|nmod|END_ENTITY	SUMO-1 / Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4 .
10383460	0	Ubc9	0,4	androgen_receptor	24,41	Ubc9	androgen receptor	7329	367	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ubc9 interacts with the androgen_receptor and activates receptor-dependent transcription .
16566921	0	Ubc9	34,38	bcl-2	14,19	Ubc9	bcl-2	22196(Tax:10090)	12043(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of bcl-2 expression by Ubc9 .
9108047	0	Ubc9p	23,28	RanBP2	0,6	Ubc9p	RanBP2	380450(Tax:8355)	100127327(Tax:8355)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	RanBP2 associates with Ubc9p and a modified form of RanGAP1 .
18331723	0	UbcH10	47,53	ubiquitin-conjugating_enzyme_E2C	14,46	UbcH10	ubiquitin-conjugating enzyme E2C	11065	11065	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of ubiquitin-conjugating_enzyme_E2C / UbcH10 in astrocytic_tumors .
16314844	0	UbcH6	49,54	TSSC5	27,32	UbcH6	TSSC5	7324	5002	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105 .
18519031	0	UbcH6	33,38	ataxin-1	114,122	UbcH6	ataxin-1	7324	6310	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	The ubiquitin-conjugating enzyme UbcH6 regulates the transcriptional repression activity of the SCA1 gene product ataxin-1 .
19340006	0	UbcH7	58,63	Triad1	21,27	UbcH7	Triad1	7332	10425	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains .
16583136	0	UbcH8	108,113	Msx2-interacting_nuclear_target_protein	17,56	UbcH8	Msx2-interacting nuclear target protein	9246	23013	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Spen homolog Msx2-interacting_nuclear_target_protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8 .
17719635	0	UbcH8	0,5	RIG-I	51,56	UbcH8	RIG-I	9246	23586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I .
22370482	0	Ube1	24,28	NEDD8	38,43	Ube1	NEDD8	7317	4738	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions .
1617221	0	Ube1	62,66	ubiquitin-activating_enzyme_E1	30,60	Ube1	ubiquitin-activating enzyme E1	22201(Tax:10090)	22201(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping and expression of the ubiquitin-activating_enzyme_E1 -LRB- Ube1 -RRB- gene in the mouse .
23863405	0	Ube2b	18,23	androgen_receptor	45,62	Ube2b	androgen receptor	22210(Tax:10090)	11835(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Ube2b as a novel target of androgen_receptor in mouse sertoli cells .
24020373	0	Ube2j1	62,68	MK2	93,96	Ube2j1	MK2	51465	9261	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 -LRB- MAPKAP_kinase-2 -RRB- involved in MK2-mediated TNFa production .
26292759	0	Ube2s	0,5	Sox2	16,20	Ube2s	Sox2	77891(Tax:10090)	20674(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Ube2s regulates Sox2 stability and mouse ES cell maintenance .
24292889	0	Ube3a	0,5	Rpn10	141,146	Ube3a	Rpn10	39266(Tax:7227)	40388(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Ube3a , the E3 ubiquitin ligase causing Angelman_syndrome and linked to autism , regulates protein homeostasis through the proteasomal shuttle Rpn10 .
23541532	0	Ubiquilin-2	0,11	TDP-43	74,80	Ubiquilin-2	TDP-43	29978	23435	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|region region|nmod|END_ENTITY	Ubiquilin-2 -LRB- UBQLN2 -RRB- binds with high affinity to the C-terminal region of TDP-43 and modulates TDP-43 levels in H4 cells : characterization of inhibition by nucleic acids and 4-aminoquinolines .
23307288	0	Ubiquilin_1	0,11	Orai1	27,32	Ubiquilin 1	Orai1	29979	84876	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ubiquilin_1 interacts with Orai1 to regulate calcium mobilization .
26643174	0	Ubiquitin-Specific_Peptidase_2	66,96	Usp2	98,102	Ubiquitin-Specific Peptidase 2	Usp2	53376(Tax:10090)	53376(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	PTH-Induced Osteoblast Proliferation Requires Upregulation of the Ubiquitin-Specific_Peptidase_2 -LRB- Usp2 -RRB- Expression .
25546086	0	Ubiquitin-specific_Protease_22	0,30	RCAN1	60,65	Ubiquitin-specific Protease 22	RCAN1	23326	1827	Gene	Gene	START_ENTITY|dep|Levels Levels|compound|END_ENTITY	Ubiquitin-specific_Protease_22 -LRB- USP22 -RRB- Positively Regulates RCAN1 Protein Levels through RCAN1 De-ubiquitination .
24923443	0	Ubiquitin-specific_peptidase_20	0,31	Rad17	42,47	Ubiquitin-specific peptidase 20	Rad17	10868	5884	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Ubiquitin-specific_peptidase_20 regulates Rad17 stability , checkpoint_kinase_1 phosphorylation and DNA repair by homologous recombination .
24349023	0	Ubiquitin-specific_peptidase_5	0,30	TNF-a	86,91	Ubiquitin-specific peptidase 5	TNF-a	297593(Tax:10116)	24835(Tax:10116)	Gene	Gene	molecule|nsubj|START_ENTITY molecule|nmod|production production|amod|END_ENTITY	Ubiquitin-specific_peptidase_5 , a target molecule of vialinin_A , is a key molecule of TNF-a production in RBL-2H3 cells .
22128162	0	Ubiquitin-specific_protease_19	0,30	HIF-1a	78,84	Ubiquitin-specific protease 19	HIF-1a	10869	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Ubiquitin-specific_protease_19 -LRB- USP19 -RRB- regulates hypoxia-inducible_factor_1a -LRB- HIF-1a -RRB- during hypoxia .
22029577	0	Ubiquitin-specific_protease_4	0,29	TRAF2	45,50	Ubiquitin-specific protease 4	TRAF2	7375	7186	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Ubiquitin-specific_protease_4 -LRB- USP4 -RRB- targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFa-induced cancer cell migration .
23603909	0	Ubiquitin-specific_protease_7	0,29	UbE2E1	77,83	Ubiquitin-specific protease 7	UbE2E1	7874	7324	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Ubiquitin-specific_protease_7 is a regulator of ubiquitin-conjugating enzyme UbE2E1 .
24525247	0	Ubiquitin_C-terminal_hydrolase_L1	0,33	choline_transporter	49,68	Ubiquitin C-terminal hydrolase L1	choline transporter	7345	60482	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Ubiquitin_C-terminal_hydrolase_L1 interacts with choline_transporter in cholinergic cells .
24399238	0	Ubiquitin_ligase	0,16	ATL31	17,22	Ubiquitin ligase	ATL31	844276(Tax:3702)	832801(Tax:3702)	Gene	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	Ubiquitin_ligase ATL31 functions in leaf senescence in response to the balance between atmospheric CO2 and nitrogen availability in Arabidopsis .
26189775	0	Ubiquitin_specific_protease_4	0,29	WNT/b-catenin	55,68	Ubiquitin specific protease 4	WNT/b-catenin	7375	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Ubiquitin_specific_protease_4 positively regulates the WNT/b-catenin signaling in colorectal_cancer .
24013421	0	Ubp-M	0,5	cyclin-dependent_kinase_1	36,61	Ubp-M	cyclin-dependent kinase 1	10600	983	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Ubp-M serine 552 phosphorylation by cyclin-dependent_kinase_1 regulates cell cycle progression .
3112353	0	Ubx	33,36	Ultrabithorax	18,31	Ubx	Ultrabithorax	42034(Tax:7227)	42034(Tax:7227)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of Ultrabithorax -LRB- Ubx -RRB- during development of the nervous system of Drosophila .
16179952	0	Ubx2	15,19	Cdc48	29,34	Ubx2	Cdc48	854995(Tax:4932)	851431(Tax:4932)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation .
18656546	0	Ubxd1	0,5	p97	40,43	Ubxd1	p97	80700	7415	Gene	Gene	co-factor|nsubj|START_ENTITY co-factor|nmod|ATPase ATPase|amod|END_ENTITY	Ubxd1 is a novel co-factor of the human p97 ATPase .
25865393	0	Ucma	0,4	Runx2	41,46	Ucma	Runx2	68527(Tax:10090)	12393(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Ucma , a direct transcriptional target of Runx2 and Osterix , promotes osteoblast differentiation and nodule formation .
25865393	0	Ucma	0,4	Runx2	41,46	Ucma	Runx2	68527(Tax:10090)	12393(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	Ucma , a direct transcriptional target of Runx2 and Osterix , promotes osteoblast differentiation and nodule formation .
7738011	0	Ucp	43,46	beta_1	51,57	Ucp	beta 1	22227(Tax:10090)	15129(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the uncoupling protein gene -LRB- Ucp -RRB- by beta_1 , beta_2 , and beta_3-adrenergic_receptor subtypes in immortalized brown adipose cell lines .
17681147	0	Ufd1	0,4	gp78	22,26	Ufd1	gp78	7353	267	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase .
26276098	0	Ufd2	20,24	Yap8	36,40	Ufd2	Yap8	851337(Tax:4932)	856329(Tax:4932)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	E4-Ubiquitin ligase Ufd2 stabilizes Yap8 and modulates arsenic stress responses independent of the U-box motif .
8890162	0	Ufd3p	22,27	Cdc48p	0,6	Ufd3p	Cdc48p	853667(Tax:4932)	851431(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cdc48p interacts with Ufd3p , a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces_cerevisiae .
9506516	0	Ufe1p	69,74	syntaxin	52,60	Ufe1p	syntaxin	854242(Tax:4932)	851219(Tax:4932)	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	Organelle membrane fusion : a novel function for the syntaxin homolog Ufe1p in ER membrane fusion .
15811345	0	Ugrp2	44,49	EGF_and_TGFalpha	65,81	Ugrp2	EGF and TGFalpha	68662(Tax:10090)	13645(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- expression by EGF_and_TGFalpha .
15811345	0	Ugrp2	44,49	uteroglobin-related_protein_2	13,42	Ugrp2	uteroglobin-related protein 2	68662(Tax:10090)	68662(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- expression by EGF_and_TGFalpha .
24253042	0	Uhrf1	135,140	SRA	92,95	Uhrf1	SRA	29128	4481	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The DNA methyltransferase Dnmt1 directly interacts with the SET and RING finger-associated -LRB- SRA -RRB- domain of the multifunctional protein Uhrf1 to facilitate accession of the catalytic center to hemi-methylated DNA .
22024743	0	Ulk1	38,42	Atg13	0,5	Ulk1	Atg13	8408	9776	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction .
20643644	0	Ulk3	39,43	UNC-51-like_kinase_3	17,37	Ulk3	UNC-51-like kinase 3	25989	25989	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Dual function of UNC-51-like_kinase_3 -LRB- Ulk3 -RRB- in the Sonic_hedgehog signaling pathway .
7555723	0	Ultrabithorax	17,30	Hox	8,11	Ultrabithorax	Hox	42034(Tax:7227)	42536(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|gene gene|compound|END_ENTITY	How the Hox gene Ultrabithorax specifies two different segments : the significance of spatial and temporal regulation within metameres .
3112353	0	Ultrabithorax	18,31	Ubx	33,36	Ultrabithorax	Ubx	42034(Tax:7227)	42034(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of Ultrabithorax -LRB- Ubx -RRB- during development of the nervous system of Drosophila .
1363225	0	Ultrabithorax	0,13	beta_3_tubulin	32,46	Ultrabithorax	beta 3 tubulin	42034(Tax:7227)	37888(Tax:7227)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Ultrabithorax is a regulator of beta_3_tubulin expression in the Drosophila visceral mesoderm .
1644294	0	Ultrabithorax	47,60	zeste	0,5	Ultrabithorax	zeste	42034(Tax:7227)	31230(Tax:7227)	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	zeste , a nonessential gene , potently activates Ultrabithorax transcription in the Drosophila embryo .
19190990	0	Umbrea	0,6	Hip	98,101	Umbrea	HP1	33661(Tax:7227)	34119(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Umbrea , a chromo shadow domain protein in Drosophila_melanogaster heterochromatin , interacts with Hip , HP1 and HOAP .
9372955	0	Ume6p	49,54	Rim11p	95,101	Ume6p	Rim11p	851788(Tax:4932)	855170(Tax:4932)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of yeast repressor-activator protein Ume6p with glycogen_synthase_kinase_3 homolog Rim11p .
10926487	0	Ump1	47,51	POMP	62,66	Ump1	POMP	51371	51371	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7 -LRB- beta_5i -RRB- incorporation into 20 S proteasomes .
18006046	0	Unbalanced	0,10	ADAMTS13	25,33	Unbalanced	ADAMTS13	21829(Tax:10090)	11093	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Unbalanced expression of ADAMTS13 and von_Willebrand factor in mouse endotoxinemia .
21589871	0	Unc-51	0,6	ATG1	7,11	Unc-51	ATG1	39454(Tax:7227)	39454(Tax:7227)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	Unc-51 / ATG1 controls axonal and dendritic development via kinesin-mediated vesicle transport in the Drosophila brain .
25541949	0	Unc-51-Like_Kinase_1	16,36	SIRT1	64,69	Unc-51-Like Kinase 1	SIRT1	22241(Tax:10090)	93759(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of Unc-51-Like_Kinase_1 by Nitric_Oxide Stabilizes SIRT1 , Independent of Autophagy .
17579091	0	Unc119	0,6	Fyn	73,76	Unc119	Fyn	9094	2534	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway .
19492039	0	Unc5B	0,5	FLRT3	21,26	Unc5B	FLRT3	100302095(Tax:8355)	503672(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos .
23700519	0	Uncoupling_protein-2	0,20	adiponectin	121,132	Uncoupling protein-2	adiponectin	7351	9370	Gene	Gene	START_ENTITY|dep|Relationship Relationship|nmod|END_ENTITY	Uncoupling_protein-2 -LRB- UCP2 -RRB- gene expression in subcutaneous and omental adipose tissue of Asian Indians : Relationship to adiponectin and parameters of metabolic_syndrome .
12351640	0	Uncoupling_protein-3	0,20	UCP3	22,26	Uncoupling protein-3	UCP3	7352	7352	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Uncoupling_protein-3 -LRB- UCP3 -RRB- mRNA expression in reconstituted human muscle after myoblast transplantation in RAG2 - / - / gamma_c / C5 -LRB- - -RRB- immunodeficient mice .
25431415	0	Uncoupling_protein_2	0,20	UCP2	27,31	Uncoupling protein 2	UCP2	7351	7351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Uncoupling_protein_2 gene -LRB- UCP2 -RRB- 45-bp I/D polymorphism is associated with adiposity among Malaysian women .
22807616	0	Uncoupling_protein_2	0,20	glucagon-like_peptide-1	31,54	Uncoupling protein 2	glucagon-like peptide-1	7351	2641	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	Uncoupling_protein_2 regulates glucagon-like_peptide-1 secretion in L-cells .
22257551	0	Uncoupling_protein_2	0,20	glucagon-like_peptide_1	58,81	Uncoupling protein 2	glucagon-like peptide 1	7351	2641	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	Uncoupling_protein_2 negatively regulates glucose-induced glucagon-like_peptide_1 secretion .
23857323	0	Ung2	101,105	Msh2	96,100	Ung2	Msh2	7374	4436	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2 + Ung2 hybrid pathway .
20225160	0	Upf1	38,42	helicase	43,51	Upf1	helicase	5976	164045	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Biochemical characterization of human Upf1 helicase .
23275559	0	Upf1	45,49	helicase	50,58	Upf1	helicase	5976	164045	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Tight intramolecular regulation of the human Upf1 helicase by its N - and C-terminal domains .
15716093	0	Upf1p	0,5	Nup100p	118,125	Upf1p	Nup100p	855104(Tax:4932)	853796(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Upf1p , a highly conserved protein required for nonsense-mediated_mRNA_decay , interacts with the nuclear pore proteins Nup100p and Nup116p .
11113196	0	Upf2	85,89	SMG-4	139,144	Upf2	SMG-4	856476(Tax:4932)	179371(Tax:6239)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification and characterization of human orthologues to Saccharomyces_cerevisiae Upf2 protein and Upf3 protein -LRB- Caenorhabditis_elegans SMG-4 -RRB- .
10393088	0	Upstream_stimulatory_factor	0,27	Pdx-1	38,43	Upstream stimulatory factor	Pdx-1	7391	3651	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Upstream_stimulatory_factor regulates Pdx-1 gene expression in differentiated pancreatic beta-cells .
12107170	0	Upstream_stimulatory_factor	0,27	delta_EF1	146,155	Upstream stimulatory factor	delta EF1	7391	6935	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Upstream_stimulatory_factor -LRB- USF -RRB- is recruited into a steroid hormone-triggered regulatory circuit by the estrogen-inducible transcription factor delta_EF1 .
12403649	0	Upstream_stimulatory_factor	0,27	vasopressin	42,53	Upstream stimulatory factor	vasopressin	7391	551	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Upstream_stimulatory_factor activates the vasopressin promoter via multiple motifs , including a non-canonical E-box .
22625849	0	Upstream_stimulatory_factor_1	0,29	GATA5	40,45	Upstream stimulatory factor 1	GATA5	7391	14464(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Upstream_stimulatory_factor_1 activates GATA5 expression through an E-box motif .
21074513	0	Urat1	72,77	Slc22a12	79,87	Urat1	Slc22a12	116085	365398(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Identification and functional characterization of uric_acid transporter Urat1 -LRB- Slc22a12 -RRB- in rats .
19703147	0	Urocortin	0,9	IL-4	20,24	Urocortin	IL-4	7349	3565	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Urocortin increases IL-4 and IL-10 secretion and reverses LPS-induced TNF-alpha release from human trophoblast primary cells .
16777977	0	Urocortin	0,9	interleukin-6	18,31	Urocortin	interleukin-6	29151(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Urocortin induces interleukin-6 gene expression via cyclooxygenase-2 activity in aortic smooth muscle cells .
19211730	0	Urocortin	0,9	interleukin-6	18,31	Urocortin	interleukin-6	29151(Tax:10116)	24498(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|amod|END_ENTITY	Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase , ERK and NF-kappaB activation .
15885216	0	Urocortin_2	0,11	c-Fos	22,27	Urocortin 2	c-Fos	170896(Tax:10116)	314322(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Urocortin_2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus .
20382145	0	Urocortin_2	0,11	c-Fos	22,27	Urocortin 2	c-Fos	90226	2353	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Urocortin_2 increases c-Fos expression in serotonergic neurons projecting to the ventricular/periventricular system .
15809070	0	Urocortin_2	0,11	tyrosine_hydroxylase	20,40	Urocortin 2	tyrosine hydroxylase	170896(Tax:10116)	25085(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Urocortin_2 induces tyrosine_hydroxylase phosphorylation in PC12 cells .
25122003	0	Urocortin_3	0,11	AMPK	22,26	Urocortin 3	AMPK	498791(Tax:10116)	78975(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|ccomp|pathways pathways|nsubj|END_ENTITY	Urocortin_3 activates AMPK and AKT pathways and enhances glucose disposal in rat skeletal muscle .
17360501	0	Urocortin_3	0,11	insulin	41,48	Urocortin 3	insulin	83428(Tax:10090)	3630	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|compound|END_ENTITY	Urocortin_3 regulates glucose-stimulated insulin secretion and energy homeostasis .
21340818	0	Urokinase-Type_Plasminogen_Activator	38,74	c-fos	13,18	Urokinase-Type Plasminogen Activator	c-fos	5328	2353	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|Expression Expression|amod|END_ENTITY	Induction of c-fos Gene Expression by Urokinase-Type_Plasminogen_Activator in Human Ovarian_Cancer Cells .
15701722	0	Urokinase-type_plasminogen_activator	0,36	PRSS22	119,125	Urokinase-type plasminogen activator	PRSS22	5328	64063	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Urokinase-type_plasminogen_activator is a preferred substrate of the human epithelium serine protease tryptase_epsilon / PRSS22 .
19812386	0	Urokinase-type_plasminogen_activator	0,36	hepatocyte_growth_factor	47,71	Urokinase-type plasminogen activator	hepatocyte growth factor	18792(Tax:10090)	15234(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	Urokinase-type_plasminogen_activator increases hepatocyte_growth_factor activity required for skeletal muscle regeneration .
20177776	0	Urokinase-type_plasminogen_activator	0,36	matrix_metalloproteinase-9	98,124	Urokinase-type plasminogen activator	matrix metalloproteinase-9	5328	4318	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Urokinase-type_plasminogen_activator induces BV-2 microglial cell migration through activation of matrix_metalloproteinase-9 .
22155455	0	Urokinase-type_plasminogen_activator	0,36	paraoxonase_1	51,64	Urokinase-type plasminogen activator	paraoxonase 1	5328	5444	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Urokinase-type_plasminogen_activator downregulates paraoxonase_1 expression in hepatocytes by stimulating peroxisome_proliferator-activated_receptor-y nuclear export .
25113506	0	Urokinase-type_plasminogen_activator_receptor	0,45	TRAIL	114,119	Urokinase-type plasminogen activator receptor	TRAIL	5329	8743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Urokinase-type_plasminogen_activator_receptor regulates apoptotic sensitivity of colon_cancer HCT116 cell line to TRAIL via JNK-p53 pathway .
25575713	0	Urokinase-type_plasminogen_activator_receptor	0,45	uPAR	47,51	Urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- expression is associated with T-stage and survival in urothelial carcinoma_of_the_bladder .
26575094	0	Urokinase_Plasminogen_Activator	55,86	uPA	88,91	Urokinase Plasminogen Activator	uPA	5328	5328	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery and SAR of Novel and Selective Inhibitors of Urokinase_Plasminogen_Activator -LRB- uPA -RRB- with an Imidazo -LSB- 1,2-a -RSB- pyridine Scaffold .
17681345	0	Urokinase_plasminogen_activator	0,31	SREBP-1	111,118	Urokinase plasminogen activator	SREBP-1	5328	6720	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|activation activation|nmod|END_ENTITY	Urokinase_plasminogen_activator -LRB- uPA -RRB- stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner .
18436804	0	Urokinase_plasminogen_activator	0,31	paraoxonase_2	44,57	Urokinase plasminogen activator	paraoxonase 2	18792(Tax:10090)	330260(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Urokinase_plasminogen_activator upregulates paraoxonase_2 expression in macrophages via an NADPH oxidase-dependent mechanism .
15110861	0	Urokinase_plasminogen_activator	32,63	uPA	65,68	Urokinase plasminogen activator	uPA	5328	5328	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	3D-QSAR CoMFA/CoMSIA studies on Urokinase_plasminogen_activator -LRB- uPA -RRB- inhibitors : a strategic design in novel anticancer agents .
10410988	0	Urokinase_plasminogen_activator_receptor	0,40	CD87	42,46	Urokinase plasminogen activator receptor	CD87	5329	5329	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Urokinase_plasminogen_activator_receptor -LRB- CD87 -RRB- expression of tumor-associated macrophages in ductal_carcinoma in situ , breast_cancer , and resident macrophages of normal breast tissue .
20716639	0	Urokinase_plasminogen_activator_receptor	0,40	matrix_metalloproteinase-9	48,74	Urokinase plasminogen activator receptor	matrix metalloproteinase-9	5329	4318	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Urokinase_plasminogen_activator_receptor and/or matrix_metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells .
16689831	0	Urokinase_plasminogen_activator_receptor	0,40	uPAR	42,46	Urokinase plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Urokinase_plasminogen_activator_receptor -LRB- uPAR -RRB- expression is reduced by tyrosine kinase inhibitors .
23466996	0	Uromodulin	0,10	TRPV5	23,28	Uromodulin	TRPV5	7369	56302	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	Uromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis .
3538018	0	Uromodulin	0,10	interleukin_1	90,103	Uromodulin	interleukin 1	7369	3552	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Uromodulin , an immunosuppressive protein derived from pregnancy urine , is an inhibitor of interleukin_1 .
16280744	0	Uroplakin_II	0,12	cytokeratin_20	116,130	Uroplakin II	cytokeratin 20	7379	54474	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Uroplakin_II as a promising marker for molecular diagnosis of nodal metastases from bladder_cancer : comparison with cytokeratin_20 .
16168405	0	Uroplakin_III	0,13	Src	23,26	Uroplakin III	Src	398743(Tax:8355)	380430(Tax:8355)	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Uroplakin_III , a novel Src substrate in Xenopus egg rafts , is a target for sperm protease essential for fertilization .
11254675	0	Uroporphyrinogen_III_synthase	0,29	GATA1	71,76	Uroporphyrinogen III synthase	GATA1	7390	2623	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Uroporphyrinogen_III_synthase erythroid promoter mutations in adjacent GATA1 and CP2 elements cause congenital_erythropoietic_porphyria .
15189768	0	Urotensin-II	0,12	c-fos	55,60	Urotensin-II	GPR14	29180(Tax:10116)	2837	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Urotensin-II , a neuropeptide ligand for GPR14 , induces c-fos in the rat brain .
12503613	0	Urotensin_II	0,12	ERK1/2	22,28	Urotensin II	ERK1/2	10911	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Urotensin_II mediates ERK1/2 phosphorylation and proliferation in GPR14-transfected cell lines .
10548501	0	Urotensin_II	0,12	GPR14	84,89	Urotensin II	GPR14	29180(Tax:10116)	57305(Tax:10116)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|receptor receptor|appos|SENR SENR|appos|END_ENTITY	Urotensin_II is the endogenous ligand of a G-protein-coupled orphan receptor , SENR -LRB- GPR14 -RRB- .
20401447	0	Urotensin_II	1,13	glucokinase	23,34	Urotensin II	glucokinase	29180(Tax:10116)	24385(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	-LSB- Urotensin_II inhibits glucokinase expression and glucose-induced insulin secretion -RSB- .
24587311	0	Urotensin_II	0,12	interleukin_8	21,34	Urotensin II	interleukin 8	10911	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Urotensin_II induces interleukin_8 expression in human umbilical vein endothelial cells .
24824254	0	Urotensin_II	0,12	monocyte_chemoattractant_protein-1	22,56	Urotensin II	monocyte chemoattractant protein-1	29180(Tax:10116)	24770(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Urotensin_II promotes monocyte_chemoattractant_protein-1 expression in aortic adventitial fibroblasts of rat .
22552405	0	Urotensin_II	0,12	p38	80,83	Urotensin II	p38	29180(Tax:10116)	81649(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Urotensin_II promotes the proliferation of endothelial progenitor cells through p38 and p44/42 MAPK activation .
23053343	0	Urotensin_II	0,12	p38	113,116	Urotensin II	p38	29180(Tax:10116)	81649(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|rat rat|nmod|MAPK MAPK|amod|END_ENTITY	Urotensin_II promotes the production of LTC4 in rat aortic adventitial fibroblasts through NF-kB-5-LO pathway by p38 MAPK and ERK activations .
18289730	0	Urotensin_II	0,12	somatostatin_receptor_subtypes_2_and_5	55,93	Urotensin II	somatostatin receptor subtypes 2 and 5	10911	6755	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Urotensin_II and urotensin_II-related_peptide activate somatostatin_receptor_subtypes_2_and_5 .
24173231	0	Us3	38,41	dUTPase	63,70	Us3	dUTPase	2703401(Tax:10298)	34529(Tax:7227)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Herpes_simplex_virus_1 protein kinase Us3 phosphorylates viral dUTPase and regulates its catalytic activity in infected cells .
15325563	0	Usher_syndrome_type_II	45,67	USH2A	31,36	Usher syndrome type II	USH2A	7399	7399	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Comprehensive screening of the USH2A gene in Usher_syndrome_type_II and non-syndromic recessive retinitis pigmentosa .
24056413	0	Usp12	24,29	androgen_receptor	61,78	Usp12	androgen receptor	9099	367	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen_receptor .
26323689	0	Usp16	0,5	Plk1	44,48	Usp16	Plk1	10600	5347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis .
26323689	0	Usp16	0,5	Plk1	44,48	Usp16	Plk1	10600	5347	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis .
26643174	0	Usp2	98,102	Ubiquitin-Specific_Peptidase_2	66,96	Usp2	Ubiquitin-Specific Peptidase 2	53376(Tax:10090)	53376(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	PTH-Induced Osteoblast Proliferation Requires Upregulation of the Ubiquitin-Specific_Peptidase_2 -LRB- Usp2 -RRB- Expression .
24991768	0	Usp9x	0,5	Mcl-1	25,30	Usp9x	Mcl-1	8239	4170	Gene	Gene	downregulation|amod|START_ENTITY downregulation|compound|END_ENTITY	Usp9x - and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung_cancer cells .
21410962	0	Uteroglobin-Related_Protein_1	13,42	UGRP1	44,49	Uteroglobin-Related Protein 1	UGRP1	117156	117156	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variation in Uteroglobin-Related_Protein_1 -LRB- UGRP1 -RRB- gene is associated with allergic_rhinitis in Singapore Chinese .
23665319	0	Utf1	34,38	Myc	0,3	Utf1	Myc	22286(Tax:10090)	17869(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain .
20650881	0	Utp14b	99,105	androgen_receptor	55,72	Utp14b	androgen receptor	195434(Tax:10090)	11835(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Gene expression alterations by conditional knockout of androgen_receptor in adult sertoli cells of Utp14b -LRB- jsd/jsd -RRB- -LRB- jsd -RRB- mice .
21312389	0	Utp14b	99,105	androgen_receptor	55,72	Utp14b	androgen receptor	195434(Tax:10090)	11835(Tax:10090)	Gene	Gene	jsd/jsd|advmod|START_ENTITY mice|amod|jsd/jsd cells|nmod|mice alterations|nmod|cells alterations|nmod|knockout knockout|nmod|END_ENTITY	Gene expression alterations by conditional knockout of androgen_receptor in adult Sertoli cells of Utp14b jsd/jsd -LRB- jsd -RRB- mice .
24647762	0	Utp21	33,38	Hsp90	54,59	Utp21	Hsp90	851125(Tax:4932)	855836(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The ribosomal biogenesis protein Utp21 interacts with Hsp90 and has differing requirements for Hsp90-associated proteins .
23194188	0	Utp22p	0,6	Utp8p	28,33	Utp22p	Utp8p	65083	853029(Tax:4932)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p .
25423496	0	Utp22p	0,6	Utp8p	28,33	Utp22p	Utp8p	65083	853029(Tax:4932)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p .
21941128	0	Utp25p	59,65	Nop19p	22,28	Utp25p	Nop19p	854717(Tax:4932)	853166(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The nucleolar protein Nop19p interacts preferentially with Utp25p and Dhr2p and is essential for the production of the 40S ribosomal subunit in Saccharomyces_cerevisiae .
23194188	0	Utp8p	28,33	Utp22p	0,6	Utp8p	Utp22p	853029(Tax:4932)	65083	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p .
25423496	0	Utp8p	28,33	Utp22p	0,6	Utp8p	Utp22p	853029(Tax:4932)	65083	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	Utp22p acts in concert with Utp8p to channel aminoacyl-tRNA from the nucleolus to the nuclear tRNA export receptor Los1p but not Msn5p .
26974331	0	Utrophin	15,23	Dystrophin	40,50	Utrophin	Dystrophin	7402	1756	Gene	Gene	Levels|compound|START_ENTITY Levels|nmod|Complex Complex|compound|END_ENTITY	Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne_and_Becker_Muscular_Dystrophy Muscle Biopsies .
10585405	0	Utrophin	0,8	dystrophin	56,66	Utrophin	dystrophin	7402	1756	Gene	Gene	lacks|nsubj|START_ENTITY lacks|dobj|activity activity|nmod|END_ENTITY	Utrophin lacks the rod domain actin binding activity of dystrophin .
10675780	0	Utrophin	0,8	dystrophin	31,41	Utrophin	dystrophin	25600(Tax:10116)	24907(Tax:10116)	Gene	Gene	precursor|nsubj|START_ENTITY precursor|nmod|END_ENTITY	Utrophin may be a precursor of dystrophin during skeletal muscle development .
8186707	0	Utrophin	0,8	dystrophin	38,48	Utrophin	dystrophin	7402	1756	Gene	Gene	START_ENTITY|dep|replacement replacement|nmod|END_ENTITY	Utrophin : a potential replacement for dystrophin ?
8866746	0	Utrophin	0,8	dystrophin	52,62	Utrophin	dystrophin	7402	1756	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Utrophin : a structural and functional comparison to dystrophin .
23900545	0	Utx	31,34	HOX	45,48	Utx	HOX	34377(Tax:7227)	42536(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The histone H3-K27 demethylase Utx regulates HOX gene expression in Drosophila in a temporally restricted manner .
26761346	0	V-ATPase	30,38	Mitf	11,15	V-ATPase	Mitf	40679(Tax:7227)	3885647(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway .
18041740	0	V1/V2	80,85	MT	96,98	V1/V2	MT	28299;6983	3176	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Stimulus-contrast-induced biases in activation order reveal interaction between V1/V2 and human MT + .
11238869	0	V1/V2	140,145	gp120	134,139	V1/V2	gp120	28299	3700	Gene	Gene	loops|nummod|START_ENTITY loops|amod|END_ENTITY	Loss of a single N-linked glycan allows CD4-independent human_immunodeficiency_virus_type_1_infection by altering the position of the gp120 V1/V2 variable loops .
11390601	0	V1/V2	56,61	gp120	142,147	V1/V2	gp120	28299	155971(Tax:11676)	Gene	Gene	sites|nmod|START_ENTITY isolate|nsubj|sites isolate|ccomp|affect affect|nsubj|END_ENTITY	N-linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human_immunodeficiency_virus_type_1 isolate DH12 gp120 affect coreceptor usage and cellular tropism .
15113902	0	V1/V2	4,9	gp120	20,25	V1/V2	gp120	28299	155971(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human_immunodeficiency_virus_type_1 isolates to neutralization by antibodies commonly induced upon infection .
16547752	0	V1/V2	23,28	gp120	17,22	V1/V2	gp120	28299	155971(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	N-Glycans in the gp120 V1/V2 domain of the HIV-1_strain NL4-3 are indispensable for viral infectivity and resistance against antibody neutralization .
18768967	0	V1/V2	18,23	gp120	97,102	V1/V2	gp120	28299	155971(Tax:11676)	Gene	Gene	region|compound|START_ENTITY Importance|nmod|region Importance|nmod|END_ENTITY	Importance of the V1/V2 loop region of simian-human_immunodeficiency_virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody response .
7533854	0	V1/V2	159,164	gp120	100,105	V1/V2	gp120	28299	3700	Gene	Gene	domain|compound|START_ENTITY folding|nmod|domain glycosylation|nmod|folding role|nmod|glycosylation Characterization|dep|role Characterization|nmod|epitopes epitopes|nmod|region region|nmod|END_ENTITY	Characterization of neutralization epitopes in the V2 region of human_immunodeficiency_virus_type_1 gp120 : role of glycosylation in the correct folding of the V1/V2 domain .
7543586	0	V1/V2	19,24	gp120	104,109	V1/V2	gp120	28299	155971(Tax:11676)	Gene	Gene	structure|compound|START_ENTITY structure|nmod|exposure exposure|nmod|epitopes epitopes|amod|END_ENTITY	Involvement of the V1/V2 variable loop structure in the exposure of human_immunodeficiency_virus_type_1 gp120 epitopes induced by receptor binding .
8139032	0	V1/V2	50,55	gp120	132,137	V1/V2	gp120	28299	155971(Tax:11676)	Gene	Gene	domains|compound|START_ENTITY interaction|nmod|domains Evidence|nmod|interaction Evidence|nmod|END_ENTITY	Evidence for a functional interaction between the V1/V2 and C4 domains of human_immunodeficiency_virus_type_1 envelope_glycoprotein gp120 .
8794361	0	V1/V2	137,142	gp120	153,158	V1/V2	gp120	28299	3700	Gene	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120 .
9795384	0	V1/V2	103,108	gp120	125,130	V1/V2	gp120	28299	155971(Tax:11676)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|HIV-1 HIV-1|nummod|END_ENTITY	Potent neutralization of primary HIV-1 isolates by antibodies directed against epitopes present in the V1/V2 domain of HIV-1 gp120 .
20083182	0	V2R	55,58	AQP1	37,41	V2R	AQP1	25108(Tax:10116)	25240(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
20083182	0	V2R	55,58	AQP2	43,47	V2R	AQP2	25108(Tax:10116)	25386(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
20083182	0	V2R	55,58	AQP3	49,53	V2R	AQP3	25108(Tax:10116)	65133(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Diuretic activity and kidney medulla AQP1 , AQP2 , AQP3 , V2R expression of the aqueous extract of sclerotia of Polyporus umbellatus FRIES in normal rats .
15469988	0	V2_receptor	30,41	vasopressin	18,29	V2 receptor	vasopressin	554	551	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the vasopressin V2_receptor by vasopressin in polarized renal collecting duct cells .
26131744	0	V2_vasopressin_receptor	16,39	AVPR2	46,51	V2 vasopressin receptor	AVPR2	554	554	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation in the V2_vasopressin_receptor gene , AVPR2 , causes nephrogenic_syndrome of inappropriate diuresis .
15539493	0	VAB-8	38,43	UNC-51	21,27	VAB-8	UNC-51	179675(Tax:6239)	180311(Tax:6239)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. _ elegans .
19917606	0	VACM-1	19,25	Cul5	26,30	VACM-1	cul5	64624(Tax:10116)	64624(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphorylation of VACM-1 / Cul5 by protein_kinase_A regulates its neddylation and antiproliferative effect .
11794467	0	VACM-1	42,48	Vasopressin-activated_calcium-mobilizing	0,40	VACM-1	Vasopressin-activated calcium-mobilizing	64624(Tax:10116)	64624(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Vasopressin-activated_calcium-mobilizing -LRB- VACM-1 -RRB- receptor mRNA is present in peripheral organs and the central nervous system of the laboratory_rat .
10898738	0	VACM-1	0,6	cullin	10,16	VACM-1	cullin	8065	143384	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	VACM-1 , a cullin gene family member , regulates cellular signaling .
9037604	0	VACM-1	51,57	cullin	61,67	VACM-1	cullin	8065	143384	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	Identification and analysis of expression of human VACM-1 , a cullin gene family member located on chromosome 11q22-23 .
20005125	0	VAMP2	76,81	vesicle_associated_membrane_protein2	38,74	VAMP2	vesicle associated membrane protein2	22318(Tax:10090)	22318(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and expression of a region of vesicle_associated_membrane_protein2 -LRB- VAMP2 -RRB- gene and its use as a recombinant peptide substrate for assaying clostridial_neurotoxins in contaminated biologicals .
14608369	0	VAMP4	20,25	AP-1	0,4	VAMP4	AP-1	53330(Tax:10090)	16476(Tax:10090)	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1 .
25572340	0	VAP-1	99,104	semicarbazide-sensitive_amine_oxidase	105,142	VAP-1	semicarbazide-sensitive amine oxidase	8639	8639	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Glitazones inhibit human monoamine oxidase but their anti-inflammatory actions are not mediated by VAP-1 / semicarbazide-sensitive_amine_oxidase inhibition .
19761765	0	VAP-1	45,50	vascular_adhesion_protein-1	16,43	VAP-1	vascular adhesion protein-1	8639	8639	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- in the human eye .
23337801	0	VAP-1	84,89	vascular_adhesion_protein-1	55,82	VAP-1	vascular adhesion protein-1	8639	8639	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and SAR study of new thiazole derivatives as vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- inhibitors for the treatment of diabetic macular_edema .
23540955	0	VAP-1	84,89	vascular_adhesion_protein-1	55,82	VAP-1	vascular adhesion protein-1	8639	8639	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and SAR study of new thiazole derivatives as vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- inhibitors for the treatment of diabetic_macular_edema : part 2 .
23664164	0	VAP-1	95,100	vascular_adhesion_protein-1	66,93	VAP-1	vascular adhesion protein-1	8639	8639	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- inhibitors for diabetic_macular_edema treatment .
19665998	0	VAP-A	106,111	glycolipid_transfer_protein	4,31	VAP-A	glycolipid transfer protein	9218	51228	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The glycolipid_transfer_protein interacts with the vesicle-associated membrane protein-associated protein VAP-A .
25612670	0	VAP-B	0,5	Rab3GAP1	15,23	VAP-B	Rab3GAP1	9217	22930	Gene	Gene	Binds|compound|START_ENTITY Binds|nmod|END_ENTITY	VAP-B Binds to Rab3GAP1 at the ER : Its Implication in Nuclear Envelope Formation through the ER-Golgi Intermediate Compartment .
20359505	0	VAPA	74,78	prestin	38,45	VAPA	prestin	30960(Tax:10090)	80979(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between the motor protein prestin and the transporter protein VAPA .
18665321	0	VAPA	99,103	vesicle-associated_membrane_protein-associated_protein_A	41,97	VAPA	vesicle-associated membrane protein-associated protein A	9218	9218	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between polymorphisms in the vesicle-associated_membrane_protein-associated_protein_A -LRB- VAPA -RRB- gene on chromosome 18p and bipolar_disorder .
22131369	0	VAPB	0,4	PTPIP51	46,53	VAPB	PTPIP51	9217	55177	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis .
17913834	0	VASP	15,19	TRPC4	25,30	VASP	TRPC4	7408	7223	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells .
12492113	0	VASP	39,43	Vasodilator-stimulated_phosphoprotein	0,37	VASP	Vasodilator-stimulated phosphoprotein	7408	7408	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein_kinase_G .
11093254	0	VASP	0,4	gelsolin	35,43	VASP	gelsolin	7408	2934	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	VASP protects actin filaments from gelsolin : an in vitro study with implications for platelet actin reorganizations .
14602552	0	VASP	62,66	vasodilator-stimulated_phosphoprotein	23,60	VASP	vasodilator-stimulated phosphoprotein	7408	7408	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of the vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- by the anti-platelet drug , cilostazol , in platelets .
16480498	0	VASP	54,58	vasodilator-stimulated_phosphoprotein	15,52	VASP	vasodilator-stimulated phosphoprotein	7408	7408	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Alterations in vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- phosphorylation : associations with asthmatic phenotype , airway inflammation and beta2-agonist use .
21163344	0	VASP	74,78	vasodilator-stimulated_phosphoprotein	35,72	VASP	vasodilator-stimulated phosphoprotein	7408	7408	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Spatial and temporal expression of vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- in fetal and adult human cerebral cortex .
22216296	0	VASP	58,62	vasodilator-stimulated_phosphoprotein	19,56	VASP	vasodilator-stimulated phosphoprotein	22323(Tax:10090)	22323(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- dampens hepatic_ischemia-reperfusion injury .
25543053	0	VASP	65,69	vasodilator-stimulated_phosphoprotein	26,63	VASP	vasodilator-stimulated phosphoprotein	7408	7408	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Serine phosphorylation of vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- regulates colon_cancer cell survival and apoptosis .
8812448	0	VASP	15,19	vasodilator-stimulated_phosphoprotein	21,58	VASP	vasodilator-stimulated phosphoprotein	7408	7408	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Cloning of the VASP -LRB- vasodilator-stimulated_phosphoprotein -RRB- genes in human and mouse : structure , sequence , and chromosomal localization .
8836115	0	VASP	58,62	vinculin	100,108	VASP	vinculin	7408	7414	Gene	Gene	vasodilator-stimulated_phosphoprotein|appos|START_ENTITY binds|nsubj|vasodilator-stimulated_phosphoprotein binds|nmod|domain domain|nmod|END_ENTITY	The focal-adhesion vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- binds to the proline-rich domain in vinculin .
8980130	0	VASP	0,4	vinculin	22,30	VASP	vinculin	7408	7414	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	VASP interaction with vinculin : a recurring theme of interactions with proline-rich motifs .
12670393	0	VAV	31,34	CD28	12,16	VAV	CD28	7409	940	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Independent CD28 signaling via VAV and SLP-76 : a model for in trans costimulation .
10713454	0	VAV	55,58	VAV3	29,33	VAV	VAV3	7409	10451	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Major transcript variants of VAV3 , a new member of the VAV family of guanine_nucleotide exchange factors .
23856093	0	VAV1	0,4	E-cadherin	15,25	VAV1	E-cadherin	7409	999	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	VAV1 represses E-cadherin expression through the transactivation of Snail and Slug : a potential mechanism for aberrant epithelial to mesenchymal transition in human epithelial_ovarian_cancer .
26224100	0	VAV2	0,4	Rac1	47,51	VAV2	Rac1	296603(Tax:10116)	363875(Tax:10116)	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	VAV2 , a guanine_nucleotide exchange factor for Rac1 , regulates glucose-stimulated insulin secretion in pancreatic beta cells .
7762982	0	VAV2	18,22	TSC1	80,84	VAV2	TSC1	7410	7248	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of VAV2 on 9q34 and its exclusion as the tuberous_sclerosis gene TSC1 .
10713454	0	VAV3	29,33	VAV	55,58	VAV3	VAV	10451	7409	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Major transcript variants of VAV3 , a new member of the VAV family of guanine_nucleotide exchange factors .
8674032	0	VBP-1	35,40	VHL	76,79	VBP-1	VHL	7411	7428	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Identification of a novel protein -LRB- VBP-1 -RRB- binding to the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor gene product .
11716764	0	VCAM-1	95,101	3-hydroxy-3-methylglutaryl-CoA_reductase	33,73	VCAM-1	3-hydroxy-3-methylglutaryl-CoA reductase	7412	3156	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Diverse effects of inhibition of 3-hydroxy-3-methylglutaryl-CoA_reductase on the expression of VCAM-1 and E-selectin in endothelial cells .
23285079	0	VCAM-1	30,36	Adiponectin	0,11	VCAM-1	Adiponectin	7412	9370	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Adiponectin and leptin induce VCAM-1 expression in human and murine chondrocytes .
16002075	0	VCAM-1	27,33	C-reactive_protein	0,18	VCAM-1	C-reactive protein	7412	1401	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	C-reactive_protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells .
7529789	0	VCAM-1	14,20	CD106	22,27	VCAM-1	CD106	7412	7412	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of VCAM-1 -LRB- CD106 -RRB- by a subset of TCR gamma delta-bearing lymphocyte clones .
15661918	0	VCAM-1	0,6	CD8	21,24	VCAM-1	CD8	7412	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|+ +|compound|END_ENTITY	VCAM-1 expression on CD8 + cells correlates with enhanced anti-HIV suppressing activity .
9888481	0	VCAM-1	106,112	E-selectin	56,66	VCAM-1	E-selectin	7412	6401	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|amod|END_ENTITY	Circulating intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in head_and_neck_cancer .
25577996	0	VCAM-1	85,91	EL	103,105	VCAM-1	EL	7412	9388	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-a-induced VCAM-1 , ICAM-1and EL expression via the NF-kB pathway .
14517226	0	VCAM-1	33,39	Endothelin-1	0,12	VCAM-1	Endothelin-1	25361(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates arterial VCAM-1 expression via NADPH oxidase-derived superoxide in mineralocorticoid hypertension .
22627111	0	VCAM-1	37,43	Endothelin-1	0,12	VCAM-1	Endothelin-1	25361(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral_sphingomyelinase .
26071554	0	VCAM-1	21,27	Endothelin-1	0,12	VCAM-1	Endothelin-1	7412	1906	Gene	Gene	Inflammation|compound|START_ENTITY Inflammation|compound|END_ENTITY	Endothelin-1 Induces VCAM-1 Expression-Mediated Inflammation via Receptor Tyrosine Kinases and Elk/p300 in Human Tracheal Smooth Muscle Cells .
26414399	0	VCAM-1	46,52	FoxO-1	61,67	VCAM-1	FoxO-1	22329(Tax:10090)	56458(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Gas6 regulates thrombin-induced expression of VCAM-1 through FoxO-1 in endothelial cells .
15308328	0	VCAM-1	34,40	G-CSF	0,5	VCAM-1	G-CSF	7412	1440	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells increases|dobj|expression increases|nsubj|END_ENTITY	G-CSF increases the expression of VCAM-1 on stromal cells promoting the adhesion of CD34 + hematopoietic cells : studies under flow conditions .
26414399	0	VCAM-1	46,52	Gas6	0,4	VCAM-1	Gas6	22329(Tax:10090)	14456(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Gas6 regulates thrombin-induced expression of VCAM-1 through FoxO-1 in endothelial cells .
18451309	0	VCAM-1	75,81	HIF-2alpha	56,66	VCAM-1	HIF-2alpha	22329(Tax:10090)	13819(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells .
10050668	0	VCAM-1	110,116	ICAM-1	93,99	VCAM-1	ICAM-1	22329(Tax:10090)	15894(Tax:10090)	Gene	Gene	interactions|compound|START_ENTITY interactions|amod|eotaxin eotaxin|nmod|modulation modulation|nmod|Mac-1 Mac-1|dep|END_ENTITY	Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1 / ICAM-1 and VLA-4 / VCAM-1 interactions .
10072550	0	VCAM-1	63,69	ICAM-1	12,18	VCAM-1	ICAM-1	7412	3383	Gene	Gene	expression|nmod|START_ENTITY leads|nmod|expression leads|nsubj|Ligation Ligation|nmod|END_ENTITY	Ligation of ICAM-1 on endothelial cells leads to expression of VCAM-1 via a nuclear factor-kappaB-independent mechanism .
11348999	0	VCAM-1	162,168	ICAM-1	154,160	VCAM-1	ICAM-1	7412	3383	Gene	Gene	CD34|dep|START_ENTITY CD34|compound|END_ENTITY	Infection of endothelium with E1 -LRB- - -RRB- E4 -LRB- + -RRB- , but not E1 -LRB- - -RRB- E4 -LRB- - -RRB- , adenovirus gene transfer vectors enhances leukocyte adhesion and migration by modulation of ICAM-1 , VCAM-1 , CD34 , and chemokine expression .
11356255	0	VCAM-1	103,109	ICAM-1	56,62	VCAM-1	ICAM-1	282118(Tax:9913)	281839(Tax:9913)	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Regulation of bovine intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- on cultured aortic endothelial cells .
11375415	0	VCAM-1	17,23	ICAM-1	33,39	VCAM-1	ICAM-1	22329(Tax:10090)	15894(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A major role for VCAM-1 , but not ICAM-1 , in early atherosclerosis .
11376630	0	VCAM-1	99,105	ICAM-1	25,31	VCAM-1	ICAM-1	7412	3383	Gene	Gene	induction|nmod|START_ENTITY Effects|dep|induction Effects|nmod|END_ENTITY	Effects of cross-linking ICAM-1 on the surface of human vascular smooth muscle cells : induction of VCAM-1 but no proliferation .
11480498	0	VCAM-1	91,97	ICAM-1	47,53	VCAM-1	ICAM-1	7412	3383	Gene	Gene	vascular_cell_adhesion_molecule-1|dep|START_ENTITY intercellular_adhesion_molecule-1|amod|vascular_cell_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	The role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- , and regulated on activation , normal T-cell expressed and secreted -LRB- RANTES -RRB- in the relationship between air pollution and asthma among children .
11493610	0	VCAM-1	49,55	ICAM-1	42,48	VCAM-1	ICAM-1	22329(Tax:10090)	15894(Tax:10090)	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|dep|END_ENTITY	IL-1_and_TNF independent pathways mediate ICAM-1 / VCAM-1 up-regulation in ischemia reperfusion injury .
11857637	0	VCAM-1	37,43	ICAM-1	20,26	VCAM-1	ICAM-1	7412	3383	Gene	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|LFA-1 LFA-1|dep|END_ENTITY	Inhibition of LFA-1 / ICAM-1 and VLA-4 / VCAM-1 as a therapeutic approach to inflammation and autoimmune_diseases .
14603993	0	VCAM-1	20,26	ICAM-1	12,18	VCAM-1	ICAM-1	7412	3383	Gene	Gene	P-selectin|appos|START_ENTITY P-selectin|compound|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFalphaRII in patients with coronary_artery_disease .
15495786	0	VCAM-1	20,26	ICAM-1	12,18	VCAM-1	ICAM-1	7412	3383	Gene	Gene	P-selectin|appos|START_ENTITY P-selectin|compound|END_ENTITY	Circulating ICAM-1 , VCAM-1 , E-selectin , P-selectin , and TNFRII in patients with coronary_artery_disease .
16303942	0	VCAM-1	47,53	ICAM-1	40,46	VCAM-1	ICAM-1	7412	3383	Gene	Gene	expression|compound|START_ENTITY implications|dep|expression implications|nmod|upregulation upregulation|nmod|END_ENTITY	The implications of the upregulation of ICAM-1 / VCAM-1 expression of corneal fibroblasts on the pathogenesis of allergic_keratopathy .
16425378	0	VCAM-1	35,41	ICAM-1	27,33	VCAM-1	ICAM-1	7412	3383	Gene	Gene	P-selectin|amod|START_ENTITY P-selectin|amod|END_ENTITY	Soluble adhesion molecules ICAM-1 , VCAM-1 , P-selectin in children with Helicobacter_pylori_infection .
16834788	0	VCAM-1	129,135	ICAM-1	82,88	VCAM-1	ICAM-1	7412	3383	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	The influence of propofol on the expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in reoxygenated human umbilical vein endothelial cells .
16981649	0	VCAM-1	123,129	ICAM-1	131,137	VCAM-1	ICAM-1	7412	3383	Gene	Gene	selectins|appos|START_ENTITY selectins|dep|END_ENTITY	Application of Evidence Investigator for the simultaneous measurement of soluble adhesion molecules : L - , _ P - , _ E - _ selectins , VCAM-1 , ICAM-1 in a biochip platform .
20300427	0	VCAM-1	48,54	ICAM-1	0,6	VCAM-1	ICAM-1	7412	3383	Gene	Gene	recruits|xcomp|START_ENTITY recruits|nsubj|END_ENTITY	ICAM-1 clustering on endothelial cells recruits VCAM-1 .
21860594	0	VCAM-1	45,51	ICAM-1	60,66	VCAM-1	ICAM-1	7412	3383	Gene	Gene	Inhibits|dobj|START_ENTITY Inhibits|dep|Not Not|nmod|Expression Expression|compound|END_ENTITY	Genipin Selectively Inhibits TNF-a-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-y in Human Endothelial Cells .
7517695	0	VCAM-1	96,102	ICAM-1	49,55	VCAM-1	ICAM-1	7412	3383	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- on proliferating vascular endothelial cells in diabetic_epiretinal_membranes .
7686390	0	VCAM-1	106,112	ICAM-1	47,53	VCAM-1	ICAM-1	7412	3383	Gene	Gene	adhesion|appos|START_ENTITY adhesion|dep|END_ENTITY	Circulating intercellular adhesion molecule-1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in human malignancies .
9180243	0	VCAM-1	178,184	ICAM-1	123,129	VCAM-1	ICAM-1	7412	3383	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	New indices of ischemic_heart_disease and aging : studies on the serum levels of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and soluble vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in patients with hypercholesterolemia and ischemic_heart_disease .
9529982	0	VCAM-1	115,121	ICAM-1	68,74	VCAM-1	ICAM-1	7412	3383	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Synchronous elevation of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- correlates with gastric_cancer progression .
9694714	0	VCAM-1	190,196	ICAM-1	137,143	VCAM-1	ICAM-1	7412	3383	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 ; CD54 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 ; CD106 -RRB- .
9888481	0	VCAM-1	106,112	ICAM-1	47,53	VCAM-1	ICAM-1	7412	3383	Gene	Gene	intercellular_adhesion_molecule_1|appos|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Circulating intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , E-selectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- in head_and_neck_cancer .
8605994	0	VCAM-1	71,77	IL-1beta	54,62	VCAM-1	IL-1beta	7412	3553	Gene	Gene	expression|compound|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	A benzothiophene-carboxamide is a potent inhibitor of IL-1beta induced VCAM-1 gene expression in human endothelial cells .
10233853	0	VCAM-1	29,35	IL-4	133,137	VCAM-1	IL-4	7412	3565	Gene	Gene	levels|nmod|START_ENTITY achieved|nsubjpass|levels achieved|nmod|END_ENTITY	Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability .
10946314	0	VCAM-1	24,30	IL-4	61,65	VCAM-1	IL-4	25361(Tax:10116)	287287(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY stimulated|nsubj|activity stimulated|nmod|END_ENTITY	The activity of soluble VCAM-1 in angiogenesis stimulated by IL-4 and IL-13 .
7533184	0	VCAM-1	18,24	IL-4	0,4	VCAM-1	IL-4	7412	3565	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IL-4 induction of VCAM-1 on endothelial cells involves activation of a protein tyrosine kinase .
9794436	0	VCAM-1	60,66	IL-6	8,12	VCAM-1	IL-6	7412	3569	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression .
19229069	0	VCAM-1	40,46	IL-8	6,10	VCAM-1	IL-8	7412	3576	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow .
21631990	0	VCAM-1	13,19	IL-8	0,4	VCAM-1	IL-8	7412	3576	Gene	Gene	secretion|compound|START_ENTITY reduces|dobj|secretion reduces|nsubj|END_ENTITY	IL-8 reduces VCAM-1 secretion of smooth muscle cells by increasing p-ERK expression when 3-D co-cultured with vascular endothelial cells .
23042815	0	VCAM-1	22,28	Id3	8,11	VCAM-1	Id3	22329(Tax:10090)	15903(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Loss of Id3 increases VCAM-1 expression , macrophage accumulation , and atherogenesis in Ldlr - / - mice .
7556668	0	VCAM-1	69,75	Interleukin-4	0,13	VCAM-1	Interleukin-4	7412	3565	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-4 induces endothelial vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by an NF-kappa_b-independent mechanism .
18032781	0	VCAM-1	78,84	JNK	104,107	VCAM-1	JNK	7412	5599	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Activation of thromboxane receptor upregulates interleukin -LRB- IL -RRB- -1 beta-induced VCAM-1 expression through JNK signaling .
22182512	0	VCAM-1	46,52	JNK	31,34	VCAM-1	JNK	7412	5599	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|MKP-7 MKP-7|appos|regulator regulator|nmod|END_ENTITY	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
11857637	0	VCAM-1	37,43	LFA-1	14,19	VCAM-1	LFA-1	7412	3683	Gene	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of LFA-1 / ICAM-1 and VLA-4 / VCAM-1 as a therapeutic approach to inflammation and autoimmune_diseases .
16644735	0	VCAM-1	84,90	Lnk	21,24	VCAM-1	Lnk	7412	10019	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The adaptor molecule Lnk negatively regulates tumor_necrosis_factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1_and _ -2 pathways .
10627468	0	VCAM-1	0,6	MAdCAM-1	30,38	VCAM-1	MAdCAM-1	7412	8174	Gene	Gene	effective|nsubj|START_ENTITY effective|nmod|END_ENTITY	VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow .
20561987	0	VCAM-1	50,56	MCP-induced_protein_1	0,21	VCAM-1	MCP-induced protein 1	7412	80149	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	MCP-induced_protein_1 suppresses TNFalpha-induced VCAM-1 expression in human endothelial cells .
22182512	0	VCAM-1	46,52	MKP-7	0,5	VCAM-1	MKP-7	7412	80824	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MKP-7 , a negative regulator of JNK , regulates VCAM-1 expression through IRF-1 .
11735124	0	VCAM-1	52,58	NF-kappaB	0,9	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappaB activation for constitutive expression of VCAM-1 and ICAM-1 on B lymphocytes and plasma cells .
11821020	0	VCAM-1	113,119	NF-kappaB	85,94	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells .
15998244	0	VCAM-1	55,61	NF-kappaB	0,9	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	expression|compound|START_ENTITY interplay|nmod|expression interplay|nsubj|END_ENTITY	NF-kappaB , Nrf2 , and HO-1 interplay in redox-regulated VCAM-1 expression .
16288471	0	VCAM-1	30,36	NF-kappaB	140,149	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|dep|involvement involvement|nmod|p300 p300|dep|END_ENTITY	Transcriptional regulation of VCAM-1 expression by tumor_necrosis_factor-alpha in human tracheal smooth muscle cells : involvement of MAPKs , NF-kappaB , p300 , and histone acetylation .
16480622	0	VCAM-1	88,94	NF-kappaB	116,125	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|acl|induced induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Activation of p38 MAPK signal transduction pathway by burn serum and the expression of VCAM-1 in HUVECs induced by NF-kappaB -RSB- .
17993261	0	VCAM-1	57,63	NF-kappaB	29,38	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	expression|amod|START_ENTITY sufficient|nmod|expression sufficient|nsubj|translocation translocation|nmod|END_ENTITY	Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1 , but not ICAM-1 , expression in TNF-stimulated smooth muscle cells : Differential requirement for PARP-1 expression and interaction .
19617655	0	VCAM-1	40,46	NF-kappaB	107,116	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	reduces|dobj|START_ENTITY reduces|advcl|inhibiting inhibiting|dobj|activation activation|appos|END_ENTITY	Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activation .
20966071	0	VCAM-1	108,114	NF-kappaB	23,32	VCAM-1	NF-kappaB	7412	4790	Gene	Gene	expression|compound|START_ENTITY critical|nmod|expression critical|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent_protein_kinase is critical for VCAM-1 expression upon TNF treatment .
10820282	0	VCAM-1	21,27	NF-kappa_B	0,10	VCAM-1	NF-kappa B	22329(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappa_B regulates VCAM-1 expression on fibroblast-like synoviocytes .
7536741	0	VCAM-1	42,48	NF-kappa_B	69,79	VCAM-1	NF-kappa B	7412	4790	Gene	Gene	promoter|compound|START_ENTITY transactivation|nmod|promoter Cell|dobj|transactivation Cell|nmod|motif motif|amod|END_ENTITY	Cell type-specific transactivation of the VCAM-1 promoter through an NF-kappa_B enhancer motif .
8543010	0	VCAM-1	33,39	NF-kappa_B	104,114	VCAM-1	NF-kappa B	22329(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY ouabain|nmod|expression effect|nmod|ouabain effect|dep|involvement involvement|nmod|END_ENTITY	Stimulatory effect of ouabain on VCAM-1 and iNOS expression in murine endothelial cells : involvement of NF-kappa_B .
24378362	0	VCAM-1	47,53	PDGFRb	69,75	VCAM-1	PDGFRb	7412	5159	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Cell-cell adhesion through N-cadherin enhances VCAM-1 expression via PDGFRb in a ligand-independent manner in mesenchymal stem cells .
19940486	0	VCAM-1	58,64	Protein_kinase_C-alpha	0,22	VCAM-1	Protein kinase C-alpha	7412	5578	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|activation activation|amod|END_ENTITY	Protein_kinase_C-alpha activation induces NF-kB-dependent VCAM-1 expression in cultured human umbilical vein endothelial cells treated with sera from preeclamptic patients .
11480498	0	VCAM-1	91,97	RANTES	167,173	VCAM-1	RANTES	7412	6352	Gene	Gene	vascular_cell_adhesion_molecule-1|dep|START_ENTITY intercellular_adhesion_molecule-1|amod|vascular_cell_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	The role of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- , and regulated on activation , normal T-cell expressed and secreted -LRB- RANTES -RRB- in the relationship between air pollution and asthma among children .
16547273	0	VCAM-1	26,32	STAT6	96,101	VCAM-1	STAT6	22329(Tax:10090)	20852(Tax:10090)	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression : involvement of STAT6 .
11944890	0	VCAM-1	76,82	Stat6	52,57	VCAM-1	Stat6	7412	6778	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1 .
20966071	0	VCAM-1	108,114	TNF	131,134	VCAM-1	TNF	7412	7124	Gene	Gene	expression|compound|START_ENTITY critical|nmod|expression critical|nmod|treatment treatment|compound|END_ENTITY	Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent_protein_kinase is critical for VCAM-1 expression upon TNF treatment .
24516119	0	VCAM-1	39,45	TNF	22,25	VCAM-1	TNF	7412	7124	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2 .
24840001	0	VCAM-1	68,74	TNF-a	52,57	VCAM-1	TNF-a	25361(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Co-treating mesenchymal stem cells with IL __ -1 b and TNF-a increases VCAM-1 expression and improves post-ischemic myocardial function .
10233853	0	VCAM-1	29,35	TNF-alpha	96,105	VCAM-1	TNF-alpha	7412	7124	Gene	Gene	levels|nmod|START_ENTITY achieved|nsubjpass|levels achieved|nmod|END_ENTITY	Sustained elevated levels of VCAM-1 in cultured fibroblast-like synoviocytes can be achieved by TNF-alpha in combination with either IL-4 or IL-13 through increased mRNA stability .
12883351	0	VCAM-1	60,66	TNF-alpha	22,31	VCAM-1	TNF-alpha	7412	7124	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Synergistic effect of TNF-alpha and either IL-4 or IL-13 on VCAM-1 expression by cultured human corneal fibroblasts .
16934424	0	VCAM-1	22,28	TNF-alpha	0,9	VCAM-1	TNF-alpha	7412	7124	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	TNF-alpha upregulates VCAM-1 and NF-kappaB in fibroblasts from nasal_polyps .
8879177	0	VCAM-1	131,137	TNF-alpha	169,178	VCAM-1	TNF-alpha	7412	7124	Gene	Gene	upregulation|compound|START_ENTITY upregulation|nmod|END_ENTITY	Eosinophil infiltration in nonallergic chronic hyperplastic_sinusitis with nasal_polyposis -LRB- CHS/NP -RRB- is associated with endothelial VCAM-1 upregulation and expression of TNF-alpha .
1280699	0	VCAM-1	35,41	Vascular_cell_adhesion_molecule-1	0,33	VCAM-1	Vascular cell adhesion molecule-1	22329(Tax:10090)	22329(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in murine lupus_nephritis .
7691889	0	VCAM-1	35,41	Vascular_cell_adhesion_molecule-1	0,33	VCAM-1	Vascular cell adhesion molecule-1	7412	7412	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells .
15265790	0	VCAM-1	35,41	Vascular_cell_adhesion_molecule_1	0,33	VCAM-1	Vascular cell adhesion molecule 1	7412	7412	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- activation of endothelial cell matrix metalloproteinases : role of reactive oxygen species .
20856927	0	VCAM-1	39,45	Vascular_cellular_adhesion_molecule-1	0,37	VCAM-1	Vascular cellular adhesion molecule-1	22329(Tax:10090)	22329(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_cellular_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia .
25277191	0	VCAM-1	62,68	Wnt-1-induced_secreted_protein_1	19,51	VCAM-1	Wnt-1-induced secreted protein 1	7412	8840	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Osteoblast-derived Wnt-1-induced_secreted_protein_1 increases VCAM-1 expression and enhances prostate_cancer metastasis by down-regulating miR-126 .
11573203	0	VCAM-1	89,95	c-fms	71,76	VCAM-1	c-fms	22329(Tax:10090)	12978(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Detection of murine adult bone marrow stroma-initiating cells in Lin -LRB- - -RRB- c-fms -LRB- + -RRB- c-kit -LRB- low -RRB- VCAM-1 -LRB- + -RRB- cells .
11573203	0	VCAM-1	89,95	c-kit	79,84	VCAM-1	c-kit	22329(Tax:10090)	16590(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Detection of murine adult bone marrow stroma-initiating cells in Lin -LRB- - -RRB- c-fms -LRB- + -RRB- c-kit -LRB- low -RRB- VCAM-1 -LRB- + -RRB- cells .
9221761	0	VCAM-1	213,219	c-kit	56,61	VCAM-1	c-kit	7412	3815	Gene	Gene	stem_cell_factor|appos|START_ENTITY receptor|nmod|stem_cell_factor receptor|amod|END_ENTITY	Human peripheral blood eosinophils express a functional c-kit receptor for stem_cell_factor that stimulates very late antigen 4 -LRB- VLA-4 -RRB- - mediated cell adhesion to fibronectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- .
22734001	0	VCAM-1	63,69	focal_adhesion_kinase	18,39	VCAM-1	focal adhesion kinase	7412	5747	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nuclear-localized focal_adhesion_kinase regulates inflammatory VCAM-1 expression .
12082081	0	VCAM-1	23,29	moesin	46,52	VCAM-1	moesin	7412	4478	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes .
19609071	0	VCAM-1	72,78	p38	84,87	VCAM-1	p38	22329(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Cadmium stimulates the expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- via p38 mitogen-activated protein kinase -LRB- MAPK -RRB- and JNK activation in cerebrovascular endothelial cells .
9020057	0	VCAM-1	59,65	p38_mitogen_activated_protein_kinase	0,36	VCAM-1	p38 mitogen activated protein kinase	7412	1432	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p38_mitogen_activated_protein_kinase regulates endothelial VCAM-1 expression at the post-transcriptional level .
17339486	0	VCAM-1	0,6	protein_tyrosine_phosphatase_1B	38,69	VCAM-1	protein tyrosine phosphatase 1B	7412	5770	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	VCAM-1 activation of endothelial cell protein_tyrosine_phosphatase_1B .
9973426	0	VCAM-1	0,6	substance_P	111,122	VCAM-1	substance P	7412	6863	Gene	Gene	expression|compound|START_ENTITY up-regulated|nsubj|expression up-regulated|nmod|END_ENTITY	VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance_P .
23770055	0	VCAM-1	107,113	tumor_necrosis_factor-a	75,98	VCAM-1	tumor necrosis factor-a	7412	7124	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	Sphingosine-1-phosphate_receptor-2 mediated NFkB activation contributes to tumor_necrosis_factor-a induced VCAM-1 and ICAM-1 expression in endothelial cells .
16288471	0	VCAM-1	30,36	tumor_necrosis_factor-alpha	51,78	VCAM-1	tumor necrosis factor-alpha	7412	7124	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Transcriptional regulation of VCAM-1 expression by tumor_necrosis_factor-alpha in human tracheal smooth muscle cells : involvement of MAPKs , NF-kappaB , p300 , and histone acetylation .
9396925	0	VCAM-1	168,174	tumor_necrosis_factor-alpha	22,49	VCAM-1	tumor necrosis factor-alpha	7412	7124	Gene	Gene	_|dobj|START_ENTITY _|advcl|Circulating Circulating|dobj|END_ENTITY	Circulating bioactive tumor_necrosis_factor-alpha , tumor_necrosis_factor-alpha_receptors , _ fibronectin , _ and_tumor_necrosis_factor-alpha inducible cell adhesion molecule VCAM-1 in uncomplicated pregnancy .
7679554	0	VCAM-1	47,53	vascular_cell_adhesion_molecule	14,45	VCAM-1	vascular cell adhesion molecule	7412	7412	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_cell_adhesion_molecule -LRB- VCAM-1 -RRB- in liver and pancreas allograft rejection .
10022460	0	VCAM-1	96,102	vascular_cell_adhesion_molecule-1	61,94	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Selective estrogen receptor modulators : different actions on vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human endothelial cells .
11223433	0	VCAM-1	71,77	vascular_cell_adhesion_molecule-1	36,69	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Selective inhibition by probucol of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human vascular endothelial cells .
11590165	0	VCAM-1	90,96	vascular_cell_adhesion_molecule-1	55,88	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cell-derived apolipoprotein_E -LRB- ApoE -RRB- particles inhibit vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human endothelial cells .
15001568	0	VCAM-1	127,133	vascular_cell_adhesion_molecule-1	92,125	VCAM-1	vascular cell adhesion molecule-1	25361(Tax:10116)	25361(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II differentially regulates interleukin-1-beta-inducible_NO_synthase -LRB- iNOS -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression : role of p38 MAPK .
15372288	0	VCAM-1	49,55	vascular_cell_adhesion_molecule-1	14,47	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Serum soluble vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- concentrations in children with reflux_nephropathy .
15553662	0	VCAM-1	146,152	vascular_cell_adhesion_molecule-1	111,144	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Nifedipine inhibits tumor_necrosis_factor-alpha-induced leukocyte adhesion to endothelial cells by suppressing vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression .
22970700	0	VCAM-1	61,67	vascular_cell_adhesion_molecule-1	26,59	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Distinct sites within the vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration .
7508348	0	VCAM-1	82,88	vascular_cell_adhesion_molecule-1	47,80	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression and function on cultured human glomerular epithelial cells .
7530745	0	VCAM-1	66,72	vascular_cell_adhesion_molecule-1	31,64	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cytokine-induced expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by astrocytes and astrocytoma cell lines .
7542574	0	VCAM-1	99,105	vascular_cell_adhesion_molecule-1	64,97	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Allergen-stimulated T lymphocytes from allergic patients induce vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression and IL-6 production by endothelial cells .
7551271	0	VCAM-1	60,66	vascular_cell_adhesion_molecule-1	25,58	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of soluble vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- correlated with expression of VCAM-1 mRNA in the human atherosclerotic aorta .
7556668	0	VCAM-1	69,75	vascular_cell_adhesion_molecule-1	34,67	VCAM-1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	induces|dep|START_ENTITY induces|dobj|END_ENTITY	Interleukin-4 induces endothelial vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by an NF-kappa_b-independent mechanism .
9050772	0	VCAM-1	49,55	vascular_cell_adhesion_molecule-1	14,47	VCAM-1	vascular cell adhesion molecule-1	100008901(Tax:9986)	100008901(Tax:9986)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in the aortae of hypercholesterolemic rabbits with high -LRB- HAR -RRB- and low -LRB- LAR -RRB- atherosclerotic response .
12547825	0	VCAM-1	118,124	vascular_cell_adhesion_molecule_1	83,116	VCAM-1	vascular cell adhesion molecule 1	7412	7412	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	17-epiestriol , an estrogen metabolite , is more potent than estradiol in inhibiting vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- mRNA expression .
25925867	0	VCAM1	88,93	SPARC	15,20	VCAM1	SPARC	7412	6678	Gene	Gene	drives|nmod|START_ENTITY drives|nsubj|END_ENTITY	Tumour-derived SPARC drives vascular permeability and extravasation through endothelial VCAM1 signalling to promote metastasis .
7506959	0	VCAM1	99,104	vascular_cell_adhesion_molecule-1	64,97	VCAM1	vascular cell adhesion molecule-1	7412	7412	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Expression and functional characterization of recombinant human vascular_cell_adhesion_molecule-1 -LRB- VCAM1 -RRB- synthesized by baculovirus-infected insect cells .
25606449	0	VCAN	25,29	Versican	15,23	VCAN	Versican	1462	1462	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association of Versican -LRB- VCAN -RRB- gene polymorphisms rs251124 and rs2287926 -LRB- G428D -RRB- , with intracranial_aneurysm .
1505973	0	VCL	64,67	vinculin	54,62	VCL	vinculin	7414	7414	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Complementary physical and genetic techniques map the vinculin -LRB- VCL -RRB- gene on chromosome 10q .
1382975	0	VCP	0,3	cdc48	30,35	VCP	cdc48	7415	851431(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	VCP , the mammalian homolog of cdc48 , is tyrosine phosphorylated in response to T_cell_antigen_receptor activation .
27086594	0	VCP	57,60	p97	52,55	VCP	p97	7415	7415	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Strategic role of the ubiquitin-dependent segregase p97 -LRB- VCP or Cdc48 -RRB- in DNA replication .
23293021	0	VCP	75,78	valosin-containing_protein	47,73	VCP	valosin-containing protein	7415	7415	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Complex of Fas-associated_factor_1 -LRB- FAF1 -RRB- with valosin-containing_protein -LRB- VCP -RRB- - Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation -LRB- ERAD -RRB- .
16822850	0	VCP/p97	15,22	Ataxin-3	0,8	VCP/p97	Ataxin-3	7415	4287	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates .
11401428	0	VCY2	84,88	BPY_2	90,95	VCY2	BPY 2	9083	9083	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization , physical mapping , and involvement in Yq microdeletions of the VCY2 -LRB- BPY_2 -RRB- gene .
9271262	0	VDAC	87,91	voltage-dependent_anion-selective_channel	44,85	VDAC	voltage-dependent anion-selective channel	34500(Tax:7227)	34500(Tax:7227)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Cloning and molecular characterization of a voltage-dependent_anion-selective_channel -LRB- VDAC -RRB- from Drosophila_melanogaster .
25470454	0	VDAC1	20,25	TSPO	0,4	VDAC1	TSPO	7416	706	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control .
20851889	0	VDAC2	32,37	Bak	14,17	VDAC2	Bak	7417	578	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor .
26727366	0	VDAC2	62,67	Voltage-Dependent_Anion_Channel_2	27,60	VDAC2	Voltage-Dependent Anion Channel 2	7417	7417	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Oyster Voltage-Dependent_Anion_Channel_2 -LRB- VDAC2 -RRB- Suggests Its Involvement in Apoptosis and Host Defense .
21406623	0	VDAC3	52,57	KP1	20,23	VDAC3	KP1	831361(Tax:3702)	823602(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arabidopsis kinesin KP1 specifically interacts with VDAC3 , a mitochondrial protein , and regulates respiration during seed germination at low temperature .
22935710	0	VDAC3	0,5	Mps1	48,52	VDAC3	Mps1	7419	219972	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes .
26290023	0	VDR	6,9	Apa1	1,5	VDR	Apa1	7421	57862	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Apa1 VDR polymorphism and osteoporosis risk in postmenopausal mexican women -RSB- .
26290023	0	VDR	6,9	Apa1	1,5	VDR	Apa1	7421	57862	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Apa1 VDR polymorphism and osteoporosis risk in postmenopausal mexican women -RSB- .
23649760	0	VDR	30,33	Cdx-2	4,9	VDR	Cdx-2	7421	1045	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	The Cdx-2 polymorphism in the VDR gene is associated with increased risk of cancer : a meta-analysis .
11082977	0	VDR	123,126	ER	151,153	VDR	ER	7421	2099	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	-LSB- The influence of hormone replacement therapy -LRB- HRT -RRB- on bone density in menopausal women in relation to vitamin_D receptor -LRB- VDR -RRB- and estrogen_receptor -LRB- ER -RRB- -RSB- .
15552843	0	VDR	136,139	ER	164,166	VDR	ER	7421	2099	Gene	Gene	vitamin_D_receptor|appos|START_ENTITY vitamin_D_receptor|appos|END_ENTITY	-LSB- The influence of hormonal replacement therapy on bone density in postmenopausal women depending on polymorphism of vitamin_D_receptor -LRB- VDR -RRB- and estrogen_receptor -LRB- ER -RRB- genes -RSB- .
20401725	0	VDR	31,34	GSTT1	41,46	VDR	GSTT1	7421	2952	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|appos|END_ENTITY	Association analysis of TNFR2 , VDR , A2M , GSTT1 , GSTM1 , and ACE genes with rheumatoid_arthritis in South Asians and Caucasians of East Midlands in the United Kingdom .
17054913	0	VDR	73,76	LXRalpha	14,22	VDR	LXRalpha	24873(Tax:10116)	58852(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Inhibition|dep|role Inhibition|nmod|END_ENTITY	Inhibition of LXRalpha signaling by vitamin_D_receptor : possible role of VDR in bile_acid synthesis .
22884583	0	VDR	153,156	PPARy	138,143	VDR	PPARy	7421	5468	Gene	Gene	binds|nmod|START_ENTITY binds|compound|END_ENTITY	Crosstalk between the peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- and the vitamin_D_receptor -LRB- VDR -RRB- in human breast_cancer cells : PPARy binds to VDR and inhibits 1a,25-dihydroxyvitamin _ D3 mediated transactivation .
15876428	0	VDR	108,111	THP-1	131,136	VDR	THP-1	7421	2736	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Lipopolysaccharide negatively modulates vitamin_D action by down-regulating expression of vitamin_D-induced VDR in human monocytic THP-1 cells .
20401725	0	VDR	31,34	TNFR2	24,29	VDR	TNFR2	7421	7133	Gene	Gene	GSTM1|appos|START_ENTITY GSTM1|compound|END_ENTITY	Association analysis of TNFR2 , VDR , A2M , GSTT1 , GSTM1 , and ACE genes with rheumatoid_arthritis in South Asians and Caucasians of East Midlands in the United Kingdom .
26504744	0	VDR	70,73	Vitamin-D_Receptor	50,68	VDR	Vitamin-D Receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Frequency of rs731236 -LRB- Taql -RRB- , rs2228570 -LRB- Fok1 -RRB- of Vitamin-D_Receptor -LRB- VDR -RRB- gene in Emirati healthy population .
16101324	0	VDR	20,23	Vitamin-D_receptor	0,18	VDR	Vitamin-D receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Vitamin-D_receptor -LRB- VDR -RRB- gene -LRB- Fok-I , Taq-I and Apa-I -RRB- polymorphisms in healthy individuals from north Indian population .
12017307	0	VDR	20,23	Vitamin_D_receptor	0,18	VDR	Vitamin D receptor	7421	7421	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- expression is not a prognostic factor in cervical_cancer .
12086963	0	VDR	20,23	Vitamin_D_receptor	0,18	VDR	Vitamin D receptor	7421	7421	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- mRNA and VDR protein levels in relation to vitamin_D status , insulin secretory capacity , and VDR genotype in Bangladeshi Asians .
12168894	0	VDR	20,23	Vitamin_D_receptor	0,18	VDR	Vitamin D receptor	7421	7421	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- expression is not a prognostic factor in breast_cancer .
17121851	0	VDR	51,54	Vitamin_D_receptor	31,49	VDR	Vitamin D receptor	7421	7421	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Stress-induced c-Jun-dependent Vitamin_D_receptor -LRB- VDR -RRB- activation dissects the non-classical VDR pathway from the classical VDR activity .
20422622	0	VDR	20,23	Vitamin_D_receptor	0,18	VDR	Vitamin D receptor	7421	7421	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- gene polymorphism is associated with left ventricular -LRB- LV -RRB- mass and predicts left_ventricular_hypertrophy -LRB- LVH -RRB- progression in end-stage_renal_disease -LRB- ESRD -RRB- patients .
21659475	0	VDR	20,23	Vitamin_D_receptor	0,18	VDR	Vitamin D receptor	7421	7421	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket -LRB- VDR-AP -RRB- .
25452584	0	VDR	47,50	WSTF	74,78	VDR	WSTF	7421	9031	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Retraction : ` Ligand-induced transrepression by VDR through association of WSTF with acetylated histones ' .
16518840	0	VDR	19,22	p27Kip1	44,51	VDR	p27Kip1	7421	1027	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|nmod|END_ENTITY	Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex .
25787039	0	VDR	46,49	vitamin-D_receptor	26,44	VDR	vitamin-D receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variations in the vitamin-D_receptor -LRB- VDR -RRB- gene in preeclampsia patients in the Chinese Han population .
18261376	0	VDR	47,50	vitamin_D_receptor	27,45	VDR	vitamin D receptor	7421	7421	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	-LSB- Association between Fok I vitamin_D_receptor -LRB- VDR -RRB- gene polymorphism and plasmatic concentrations of transforming_growth_factor-beta1 and interferon_gamma in type 1 diabetes_mellitus -RSB- .
20419464	0	VDR	30,33	vitamin_D_receptor	10,28	VDR	vitamin D receptor	7421	7421	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vitamin_D_receptor -LRB- VDR -RRB- genotypes on the risk for osteoporosis in type_1_Gaucher_disease .
22564539	0	VDR	40,43	vitamin_D_receptor	20,38	VDR	vitamin D receptor	7421	7421	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of vitamin_D_receptor -LRB- VDR -RRB- in lung_adenocarcinoma .
22960018	0	VDR	46,49	vitamin_D_receptor	21,39	VDR	vitamin D receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Investigation of the vitamin_D_receptor gene -LRB- VDR -RRB- and its interaction with protein_tyrosine_phosphatase , _ non-receptor_type_2_gene -LRB- PTPN2 -RRB- on risk of islet autoimmunity and type_1_diabetes : the Diabetes_Autoimmunity Study in the Young -LRB- DAISY -RRB- .
23352876	0	VDR	46,49	vitamin_D_receptor	26,44	VDR	vitamin D receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Allelic variations of the vitamin_D_receptor -LRB- VDR -RRB- gene are associated with increased risk of coronary_artery_disease in type 2 diabetics : the DIABHYCAR prospective study .
25059118	0	VDR	51,54	vitamin_D_receptor	26,44	VDR	vitamin D receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between Fok I vitamin_D_receptor gene -LRB- VDR -RRB- polymorphism and impulsivity in alcohol-dependent patients .
25661837	0	VDR	40,43	vitamin_D_receptor	20,38	VDR	vitamin D receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between vitamin_D_receptor -LRB- VDR -RRB- gene polymorphisms and systemic_lupus_erythematosus in Portuguese patients .
25773805	0	VDR	41,44	vitamin_D_receptor	21,39	VDR	vitamin D receptor	7421	7421	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Associations between vitamin_D_receptor -LRB- VDR -RRB- gene polymorphisms and colorectal_cancer risk and effect modifications of dietary calcium and vitamin_D in a Japanese population .
26400282	0	VDR	41,44	vitamin_D_receptor	21,39	VDR	vitamin D receptor	7421	7421	Gene	Gene	Relationship|appos|START_ENTITY Relationship|nmod|END_ENTITY	Relationship between vitamin_D_receptor -LRB- VDR -RRB- polymorphisms and the efficacy of recombinant human growth_hormone -LRB- rhGH -RRB- treatment in children with idiopathic_short_stature .
9586948	0	VDR	83,86	vitamin_D_receptor	63,81	VDR	vitamin D receptor	7421	7421	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Inhibition of the 1,25-dihydroxyvitamin _ D3-induced increase in vitamin_D_receptor -LRB- VDR -RRB- levels and binding of VDR-retinoid_X_receptor -LRB- RXR -RRB- to a direct_repeat _ -LRB- DR -RRB- -3 type response element by an RXR-specific ligand in human keratinocyte cultures .
14766217	0	VDUP1	28,33	Heat_shock_factor	0,17	VDUP1	Heat shock factor	10628	3569	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Heat_shock_factor regulates VDUP1 gene expression .
11579135	0	VDUP1	93,98	vitamin_D3_up-regulated_protein_1	58,91	VDUP1	vitamin D3 up-regulated protein 1	10628	10628	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Rapid induction and Ca -LRB- 2 + -RRB- influx-mediated suppression of vitamin_D3_up-regulated_protein_1 -LRB- VDUP1 -RRB- mRNA in cerebellar granule neurons undergoing apoptosis .
25657827	0	VE-Cadherin	33,44	P2Y2	4,8	VE-Cadherin	P2Y2	1003	5029	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	The P2Y2 Receptor Interacts with VE-Cadherin and VEGF Receptor-2 to Regulate Rac1 Activity in Endothelial Cells .
25180601	0	VE-PTP	10,16	TIE2	27,31	VE-PTP	TIE2	19263(Tax:10090)	21687(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature .
8786117	0	VE-cadherin	55,66	Cdh5	73,77	VE-cadherin	Cdh5	12562(Tax:10090)	12562(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosomal mapping of the mouse VE-cadherin gene -LRB- Cdh5 -RRB- .
15861137	0	VE-cadherin	22,33	Csk	15,18	VE-cadherin	Csk	1003	1445	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Csk to VE-cadherin and inhibition of cell proliferation .
21190990	0	VE-cadherin	55,66	Dentin_matrix_protein_1	0,23	VE-cadherin	Dentin matrix protein 1	1003	1758	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Dentin_matrix_protein_1 induces membrane expression of VE-cadherin on endothelial cells and inhibits VEGF-induced angiogenesis by blocking VEGFR-2 phosphorylation .
17242194	0	VE-cadherin	52,63	E47	27,30	VE-cadherin	E47	1003	6929	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	TAL-1 / SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells .
16115630	0	VE-cadherin	64,75	Epac1	0,5	VE-cadherin	Epac1	1003	10411	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Epac1 regulates integrity of endothelial cell junctions through VE-cadherin .
16481735	0	VE-cadherin	0,11	EphA2	22,27	VE-cadherin	EphA2	1003	1969	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway : implications for vasculogenic mimicry .
18195090	0	VE-cadherin	82,93	Erg	21,24	VE-cadherin	Erg	1003	2078	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin .
9521912	0	VE-cadherin	73,84	FLK1	68,72	VE-cadherin	FLK1	12562(Tax:10090)	16542(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|nummod|END_ENTITY	Progressive lineage analysis by cell sorting and culture identifies FLK1 + VE-cadherin + cells at a diverging point of endothelial and hemopoietic lineages .
15070677	0	VE-cadherin	19,30	Gas1	0,4	VE-cadherin	Gas1	1003	2619	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Gas1 is induced by VE-cadherin and vascular_endothelial_growth_factor and inhibits endothelial cell apoptosis .
25548487	0	VE-cadherin	15,26	HIF-1a	0,6	VE-cadherin	HIF-1a	12562(Tax:10090)	15251(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	HIF-1a induces VE-cadherin expression and modulates vasculogenic mimicry in esophageal_carcinoma cells .
22492353	0	VE-cadherin	33,44	SOX7	0,4	VE-cadherin	SOX7	12562(Tax:10090)	20680(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development .
26642851	0	VE-cadherin	93,104	Tie-2	69,74	VE-cadherin	Tie-2	1003	7010	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin .
9625748	0	VE-cadherin	43,54	Vascular_endothelial_growth_factor	0,34	VE-cadherin	Vascular endothelial growth factor	1003	7422	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces VE-cadherin tyrosine phosphorylation in endothelial cells .
22391038	0	VE-cadherin	37,48	Vinculin	0,8	VE-cadherin	Vinculin	1003	7414	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling .
26668327	0	VE-cadherin	37,48	YAP	63,66	VE-cadherin	YAP	12562(Tax:10090)	22601(Tax:10090)	Gene	Gene	localization|amod|START_ENTITY localization|compound|END_ENTITY	The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling .
19918298	0	VE-cadherin	37,48	alpha-catenin	16,29	VE-cadherin	alpha-catenin	1003	1495	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial_migration of leukocytes .
10063232	0	VE-cadherin	44,55	cadherin_5	32,42	VE-cadherin	cadherin 5	1003	1003	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	An immunohistochemical study of cadherin_5 -LRB- VE-cadherin -RRB- in vascular endothelial cells in placentas with gestosis .
19358279	0	VE-cadherin	4,15	fibrinogen	34,44	VE-cadherin	fibrinogen	1003	2244	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial_migration of malignant breast epithelial cells .
26317647	0	VEGF	78,82	A2B	47,50	VEGF	A2B	22339(Tax:10090)	11541(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nummod|END_ENTITY	Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model .
18272597	0	VEGF	82,86	ADAMTS-1	64,72	VEGF	ADAMTS-1	83785(Tax:10116)	79252(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Renal_ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1 , a novel VEGF inhibitor .
23429328	0	VEGF	14,18	AKT	20,23	VEGF	AKT	7422	207	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
16678800	0	VEGF	95,99	AMP-activated_protein_kinase	18,46	VEGF	AMP-activated protein kinase	7422	5563	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Critical roles of AMP-activated_protein_kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145_prostate_carcinoma .
24179522	0	VEGF	121,125	AMPK	82,86	VEGF	AMPK	7422	5563	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Pro-apoptotic and migration-suppressing potential of EGCG , and the involvement of AMPK in the p53-mediated modulation of VEGF and MMP-9 expression .
24330582	0	VEGF	37,41	ATF4	61,65	VEGF	ATF4	7422	468	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	An aryl_hydrocarbon_receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 .
24746698	0	VEGF	0,4	ATF6	21,25	VEGF	ATF6	22339(Tax:10090)	226641(Tax:10090)	Gene	Gene	Signals|nsubj|START_ENTITY Signals|nmod|END_ENTITY	VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress .
22178239	0	VEGF	30,34	Adrenomedullin	0,14	VEGF	Adrenomedullin	7422	133	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Adrenomedullin interacts with VEGF in endometrial_cancer and has varied modulation in tumours of different grades .
20441791	0	VEGF	75,79	AlphaB-crystallin	0,17	VEGF	AlphaB-crystallin	22339(Tax:10090)	12955(Tax:10090)	Gene	Gene	determined|nmod|START_ENTITY protection|acl|determined involved|nmod|protection involved|nsubjpass|END_ENTITY	AlphaB-crystallin is involved in oxidative stress protection determined by VEGF in skeletal myoblasts .
15823283	0	VEGF	72,76	Angiopoietin-1	0,14	VEGF	Angiopoietin-1	7422	284	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Angiopoietin-1 and angiopoietin-2 in diabetes_mellitus : relationship to VEGF , glycaemic control , endothelial_damage / dysfunction and atherosclerosis .
23149917	0	VEGF	91,95	Angiopoietin-2	0,14	VEGF	Angiopoietin-2	7422	285	Gene	Gene	inhibition|compound|START_ENTITY effects|nmod|inhibition limits|dobj|effects agonist|advcl|limits agonist|nsubj|functions functions|amod|END_ENTITY	Angiopoietin-2 functions as a Tie2 agonist in tumor models , where it limits the effects of VEGF inhibition .
25312939	0	VEGF	60,64	Angiopoietin-2	14,28	VEGF	Angiopoietin-2	7422	285	Gene	Gene	interference|amod|START_ENTITY conjunction|nmod|interference axis|nmod|conjunction axis|dep|Targeting Targeting|dobj|END_ENTITY	Targeting the Angiopoietin-2 / Tie-2 axis in conjunction with VEGF signal interference .
16249273	0	VEGF	30,34	Angiotensin_II	0,14	VEGF	Angiotensin II	7422	183	Gene	Gene	translation|compound|START_ENTITY stimulation|nmod|translation stimulation|compound|END_ENTITY	Angiotensin_II stimulation of VEGF mRNA translation requires production of reactive oxygen species .
18354258	0	VEGF	50,54	Angiotensin_II	0,14	VEGF	Angiotensin II	83785(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces the vascular expression of VEGF and MMP-2 in vivo : preventive effect of red wine polyphenols .
20817051	0	VEGF	66,70	Annexin_A2	18,28	VEGF	Annexin A2	22339(Tax:10090)	12306(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY increases|nmod|cells increases|dobj|expression expression|amod|END_ENTITY	Hypoxia increases Annexin_A2 expression in osteoblastic cells via VEGF and ERK .
25378933	0	VEGF	54,58	B7-H3	0,5	VEGF	B7-H3	7422	80381	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	B7-H3 expression in breast_cancer and upregulation of VEGF through gene silence .
15273770	0	VEGF	67,71	BAX	56,59	VEGF	BAX	7422	581	Gene	Gene	Bcl-2|dep|START_ENTITY Bcl-2|dep|END_ENTITY	Expression of biomolecular markers -LRB- Ki-67 , PCNA , Bcl-2 , BAX , BclX , VEGF -RRB- in breast_tumors .
11461089	0	VEGF	36,40	BCL-2	54,59	VEGF	BCL-2	7422	596	Gene	Gene	Vascular_endothelial_growth_factor|appos|START_ENTITY upregulates|nsubj|Vascular_endothelial_growth_factor upregulates|dobj|apoptosis apoptosis|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells .
23160675	0	VEGF	19,23	BCL-2	68,73	VEGF	BCL-2	7422	596	Gene	Gene	expression|compound|START_ENTITY compensation|nmod|expression follows|nsubj|compensation follows|dobj|suppression suppression|nmod|activity activity|compound|END_ENTITY	No compensation in VEGF expression follows antisense suppression of BCL-2 activity .
25735814	0	VEGF	39,43	Basic_fibroblast_growth_factor	0,30	VEGF	Basic fibroblast growth factor	7422	2247	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces VEGF expression in chondrosarcoma cells and subsequently promotes endothelial progenitor cell-primed angiogenesis .
23994239	0	VEGF	66,70	Bax	94,97	VEGF	Bax	7422	581	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Significant modulation of macrophages associated cytokines TNF-a , VEGF and apoptotoic protein Bax , Bcl2 abrogates_tumor cells .
11877669	0	VEGF	0,4	Bcl-2	17,22	VEGF	Bcl-2	7422	596	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	VEGF upregulates Bcl-2 expression and is associated with decreased apoptosis in neuroblastoma cells .
11895790	0	VEGF	0,4	Bcl-2	77,82	VEGF	Bcl-2	7422	596	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	VEGF -LRB- 165 -RRB- promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition .
12205045	0	VEGF	76,80	Bcl-2	0,5	VEGF	Bcl-2	7422	596	Gene	Gene	stabilization|amod|START_ENTITY increases|nmod|stabilization increases|nsubj|overexpression overexpression|amod|END_ENTITY	Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity .
19495772	0	VEGF	0,4	Bcl-2	27,32	VEGF	Bcl-2	7422	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|acl|signaling signaling|xcomp|END_ENTITY	VEGF induces expression of Bcl-2 and multiple signaling factors in microvascular endothelial cells in a prostate_cancer model .
23994239	0	VEGF	66,70	Bcl2	99,103	VEGF	Bcl2	7422	596	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	Significant modulation of macrophages associated cytokines TNF-a , VEGF and apoptotoic protein Bax , Bcl2 abrogates_tumor cells .
9713280	0	VEGF	58,62	Bcl2	0,4	VEGF	Bcl2	7422	596	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|compound|END_ENTITY	Bcl2 and p53 regulate vascular_endothelial_growth_factor -LRB- VEGF -RRB- - mediated angiogenesis in non-small_cell_lung_carcinoma .
25371074	0	VEGF	58,62	Biglycan	0,8	VEGF	Biglycan	7422	633	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Biglycan up-regulated vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and promoted angiogenesis in colon_cancer .
24023033	0	VEGF	75,79	Bone_morphogenetic_protein_7	0,28	VEGF	Bone morphogenetic protein 7	7422	655	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Bone_morphogenetic_protein_7 increased vascular_endothelial_growth_factor -LRB- VEGF -RRB- - a expression in human granulosa cells and VEGF receptor expression in endothelial cells .
19172471	0	VEGF	28,32	C5a	0,3	VEGF	C5a	7422	728	Gene	Gene	secretion|compound|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	C5a , but not C3a , increases VEGF secretion in ARPE-19 human retinal pigment epithelial cells .
17522124	0	VEGF	25,29	CCR2	44,48	VEGF	CCR2	22339(Tax:10090)	12772(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Delayed angiogenesis and VEGF production in CCR2 - / - mice during impaired skeletal muscle regeneration .
26107446	0	VEGF	76,80	CD34	91,95	VEGF	CD34	7422	947	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Study of novel coating strategy for coronary stents : simutaneous coating of VEGF and anti- CD34 antibody .
19928818	0	VEGF	36,40	CD36	156,160	VEGF	CD36	22339(Tax:10090)	12491(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|dep|association association|nmod|END_ENTITY	Dietary compound quercitrin dampens VEGF induction and PPARgamma activation in oxidized LDL-exposed murine macrophages : association with scavenger receptor CD36 .
23896411	0	VEGF	27,31	CD36	46,50	VEGF	CD36	22339(Tax:10090)	12491(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells .
20705519	0	VEGF	36,40	CD4	44,47	VEGF	CD4	7422	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Increased spontaneous production of VEGF by CD4 + T cells in type 1 diabetes .
23429328	0	VEGF	14,18	CD40	8,12	VEGF	CD40	7422	958	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
26706786	0	VEGF	22,26	CD40L	39,44	VEGF	CD40L	7422	959	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Diagnostic utility of VEGF and soluble CD40L levels in serum of Alzheimer 's patients .
12881220	0	VEGF	81,85	COX-2	34,39	VEGF	COX-2	7422	4513	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|compound|END_ENTITY	Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells : role of VEGF .
15358633	0	VEGF	17,21	COX-2	76,81	VEGF	COX-2	7422	5743	Gene	Gene	expression|amod|START_ENTITY reduce|dobj|expression reduce|nmod|cells cells|acl|modulating modulating|dobj|pathway pathway|compound|-2 -2|compound|END_ENTITY	n-3 PUFAs reduce VEGF expression in human colon_cancer cells modulating the COX-2 / PGE2 induced ERK-1_and _ -2 and HIF-1alpha induction pathway .
15842638	0	VEGF	43,47	COX-2	0,5	VEGF	COX-2	7422	4513	Gene	Gene	HER-2|compound|START_ENTITY correlation|nmod|HER-2 expression|dep|correlation expression|compound|END_ENTITY	COX-2 expression in DCIS : correlation with VEGF , HER-2 / neu , prognostic molecular markers and clinicopathological features .
15968728	2	VEGF	464,468	COX-2	457,462	VEGF	COX-2	7422	5743	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	METHODS : Sixty-four gallbladder_carcinoma specimens were evaluated for COX-2 , VEGF expression by immunohistochemical methods .
16806797	0	VEGF	25,29	COX-2	44,49	VEGF	COX-2	7422	5743	Gene	Gene	levels|amod|START_ENTITY circulating|dobj|levels circulating|nmod|treatment treatment|compound|END_ENTITY	Increases in circulating VEGF levels during COX-2 inhibitor treatment in breast_cancer patients .
17687613	0	VEGF	27,31	COX-2	63,68	VEGF	COX-2	7422	5743	Gene	Gene	expression|compound|START_ENTITY significance|nmod|expression significance|nmod|END_ENTITY	Prognostic significance of VEGF expression in correlation with COX-2 , microvessel density , and clinicopathological characteristics in human gastric_carcinoma .
18093816	0	VEGF	62,66	COX-2	0,5	VEGF	COX-2	7422	4513	Gene	Gene	linked|xcomp|START_ENTITY linked|nsubjpass|END_ENTITY	COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells .
18533784	0	VEGF	27,31	COX-2	0,5	VEGF	COX-2	83785(Tax:10116)	26198(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|decreases decreases|compound|END_ENTITY	COX-2 inhibition decreases VEGF expression and alveolar_bone_loss during the progression of experimental periodontitis in rats .
20398651	0	VEGF	37,41	COX-2	20,25	VEGF	COX-2	22339(Tax:10090)	17709(Tax:10090)	Gene	Gene	production|amod|START_ENTITY diminishes|dobj|production diminishes|nsubj|deletion deletion|nmod|END_ENTITY	Genetic deletion of COX-2 diminishes VEGF production in mouse retinal M ller cells .
20675158	0	VEGF	38,42	COX-2	0,5	VEGF	COX-2	7422	5743	Gene	Gene	angiogenesis|compound|START_ENTITY correlates|nmod|angiogenesis correlates|nsubj|over-expression over-expression|compound|END_ENTITY	COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer .
21335003	0	VEGF	27,31	COX-2	33,38	VEGF	COX-2	7422	4513	Gene	Gene	Correlation|nmod|START_ENTITY END_ENTITY|nsubj|Correlation	Correlation of E-cadherin , VEGF , COX-2 expression to prognostic parameters in papillary_thyroid_carcinoma .
23114124	0	VEGF	56,60	COX-2	12,17	VEGF	COX-2	7422	4513	Gene	Gene	mRNA|amod|START_ENTITY expressions|nmod|mRNA celecoxib|nmod|expressions celecoxib|compound|END_ENTITY	-LSB- Effects of COX-2 inhibitor celecoxib on expressions of VEGF , b-FGF and TGF-b mRNA in acute_leukemia cells -RSB- .
24284961	0	VEGF	73,77	COX-2	109,114	VEGF	COX-2	7422	4513	Gene	Gene	production|amod|START_ENTITY production|nmod|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	Apurinic/apyrimidinic _ endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal_cancer tissues .
26675577	0	VEGF	73,77	COX-2	102,107	VEGF	COX-2	7422	5743	Gene	Gene	MMP-9|compound|START_ENTITY MMP-9|appos|activity activity|nmod|END_ENTITY	-LSB- Targeted interruption of COX-2 gene by siRNA inhibits the expression of VEGF , MMP-9 , the activity of COX-2 and stimulates the apoptosis in eutopic , ectopic endometrial stromal cells of women with endometriosis -RSB- .
26675577	0	VEGF	73,77	COX-2	26,31	VEGF	COX-2	7422	5743	Gene	Gene	MMP-9|compound|START_ENTITY expression|nmod|MMP-9 inhibits|dobj|expression inhibits|nsubj|interruption interruption|nmod|gene gene|compound|END_ENTITY	-LSB- Targeted interruption of COX-2 gene by siRNA inhibits the expression of VEGF , MMP-9 , the activity of COX-2 and stimulates the apoptosis in eutopic , ectopic endometrial stromal cells of women with endometriosis -RSB- .
26627607	0	VEGF	74,78	CPEB1	24,29	VEGF	CPEB1	7422	64506	Gene	Gene	Functions|nmod|START_ENTITY Functions|nmod|END_ENTITY	Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of VEGF and Angiogenesis in Chronic_Liver_Disease .
21306303	0	VEGF	14,18	CXCR4	44,49	VEGF	CXCR4	22339(Tax:10090)	12767(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of VEGF , MMP-9 and metastasis by CXCR4 in a prostate_cancer cell line .
20353560	0	VEGF	111,115	CaMKII	119,125	VEGF	CaMKII	7422	818	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions ; significant reduction of VEGF by CaMKII inhibitor .
21826216	0	VEGF	107,111	Caveolin-1	0,10	VEGF	Caveolin-1	7422	857	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway differentiation|nmod|cells inhibiting|dobj|differentiation plays|advcl|inhibiting plays|nsubj|END_ENTITY	Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway .
11326316	0	VEGF	41,45	Cyclooxygenase-2	0,16	VEGF	Cyclooxygenase-2	7422	5743	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|END_ENTITY	Cyclooxygenase-2 pathway correlates with VEGF expression in head_and_neck_cancer .
15175101	0	VEGF	56,60	Cyclosporin_A	0,13	VEGF	Cyclosporin A	7422	1161	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Cyclosporin_A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling .
15649872	0	VEGF	33,37	Cyr61	0,5	VEGF	Cyr61	7422	3491	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Cyr61 mediates the expression of VEGF , alphav-integrin , and alpha-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells .
15016650	0	VEGF	57,61	DSCR1	41,46	VEGF	DSCR1	7422	1827	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Down_syndrome_critical_region_protein_1 -LRB- DSCR1 -RRB- , a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells .
17296940	0	VEGF	41,45	Delta-like_ligand_4	0,19	VEGF	Delta-like ligand 4	7422	54567	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Delta-like_ligand_4 -LRB- Dll4 -RRB- is induced by VEGF as a negative regulator of angiogenic sprouting .
21517260	0	VEGF	47,51	Delta-like_ligand_4	15,34	VEGF	Delta-like ligand 4	7422	54567	Gene	Gene	expression|amod|START_ENTITY Correlation|nmod|expression Correlation|nmod|END_ENTITY	Correlation of Delta-like_ligand_4 -LRB- DLL4 -RRB- with VEGF and HIF-1a expression in human glioma .
15263820	0	VEGF	56,60	Down_syndrome_candidate_region_1	0,32	VEGF	Down syndrome candidate region 1	7422	1827	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Down_syndrome_candidate_region_1 , a downstream target of VEGF , participates in endothelial cell migration and angiogenesis .
12063543	0	VEGF	66,70	EGFR	0,4	VEGF	EGFR	7422	1956	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|treatment treatment|amod|END_ENTITY	EGFR antisense treatment of human HNSCC cell lines down-regulates VEGF expression and endothelial cell migration .
16540671	0	VEGF	41,45	EGFR	0,4	VEGF	EGFR	7422	1956	Gene	Gene	expression|amod|START_ENTITY decrease|dobj|expression tyrosine|ccomp|decrease tyrosine|nsubj|END_ENTITY	EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 - independent and HIF-1-dependent mechanisms .
16760272	0	VEGF	108,112	EGFR	58,62	VEGF	EGFR	7422	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Interaction between the epidermal_growth_factor_receptor -LRB- EGFR -RRB- and the vascular_endothelial_growth_factor -LRB- VEGF -RRB- pathways : a rational approach for multi-target anticancer therapy .
17896140	0	VEGF	50,54	EGFR	94,98	VEGF	EGFR	7422	1956	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and epidermal_growth_factor_receptor -LRB- EGFR -RRB- is an independent prognostic indicator of worse outcome in gastric_cancer patients .
19234131	0	VEGF	36,40	EGFR	109,113	VEGF	EGFR	7422	1956	Gene	Gene	START_ENTITY|xcomp|containing containing|dobj|END_ENTITY	Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR .
20141840	0	VEGF	10,14	EGFR	41,45	VEGF	EGFR	22339(Tax:10090)	13649(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|dobj|synergizes synergizes|nmod|END_ENTITY	Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development .
23913252	0	VEGF	113,117	EGFR	107,111	VEGF	EGFR	7422	1956	Gene	Gene	CD34|compound|START_ENTITY END_ENTITY|dep|CD34	Prognostic significance of human_papillomavirus _ -LRB- HPV -RRB- status and expression of selected markers -LRB- HER2/neu , EGFR , VEGF , CD34 , p63 , p53 and Ki67/MIB -1 -RRB- on outcome after -LRB- chemo - -RRB- radiotherapy in patients with squamous_cell_carcinoma_of_uterine_cervix .
25272226	0	VEGF	20,24	EGFR	70,74	VEGF	EGFR	7422	1956	Gene	Gene	Production|compound|START_ENTITY Potentiation|nmod|Production Dependent|nsubj|Potentiation Dependent|nmod|Line Line|compound|END_ENTITY	EGF Potentiation of VEGF Production Is Cell Density Dependent in H292 EGFR Wild Type NSCLC Cell Line .
26478789	0	VEGF	50,54	EGFR	94,98	VEGF	EGFR	7422	1956	Gene	Gene	Vascular_Endothelial_Growth_Factor|appos|START_ENTITY Vascular_Endothelial_Growth_Factor|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- and Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- in Patients With Serous_Ovarian_Carcinoma and Their Clinical Significance .
16328781	0	VEGF	26,30	ERK	50,53	VEGF	ERK	7422	5594	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Hyperbaric oxygen induces VEGF expression through ERK , JNK and c-Jun/AP -1 activation in human umbilical vein endothelial cells .
16810296	0	VEGF	47,51	ERK	102,105	VEGF	ERK	7422	5594	Gene	Gene	production|compound|START_ENTITY production|nmod|inhibition inhibition|nmod|activation activation|compound|END_ENTITY	All-trans_retinoic_acid antagonizes UV-induced VEGF production and angiogenesis via the inhibition of ERK activation in human skin keratinocytes .
20812001	0	VEGF	73,77	ERK	19,22	VEGF	ERK	7422	5594	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability Implication|nmod|regulation Implication|nmod|pathway pathway|compound|END_ENTITY	Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability .
22659165	0	VEGF	0,4	ERK	110,113	VEGF	ERK	7422	5594	Gene	Gene	induces|nsubj|START_ENTITY induces|ccomp|follicle follicle|nmod|activation activation|nmod|END_ENTITY	VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK .
23936001	0	VEGF	27,31	ERK	65,68	VEGF	ERK	7422	5594	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Melittin suppresses HIF-1a / VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical_carcinoma cells .
25100161	0	VEGF	13,17	ERK	58,61	VEGF	ERK	7422	5594	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|signalling signalling|compound|END_ENTITY	LL37 induces VEGF expression in dental pulp cells through ERK signalling .
19839874	0	VEGF	73,77	ERK1/2	55,61	VEGF	ERK1/2	7422	5595;5594	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Impact of the transfer of sFlt-1 gene fragments on the ERK1/2 pathway of VEGF in vitro .
16998811	0	VEGF	43,47	EZH2	49,53	VEGF	EZH2	7422	2146	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
24986100	0	VEGF	46,50	EZH2	0,4	VEGF	EZH2	7422	2146	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|nsubj|END_ENTITY	EZH2 promotes tumor progression by increasing VEGF expression in clear_cell_renal_cell_carcinoma .
22571958	0	VEGF	52,56	Eng	43,46	VEGF	Eng	22339(Tax:10090)	13805(Tax:10090)	Gene	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	Minimal homozygous endothelial deletion of Eng with VEGF stimulation is sufficient to cause cerebrovascular_dysplasia in the adult mouse .
19797898	0	VEGF	18,22	ErbB3	42,47	VEGF	ErbB3	7422	2065	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Heregulin-induced VEGF expression via the ErbB3 signaling pathway in colon_cancer .
17685427	0	VEGF	13,17	Erk	106,109	VEGF	Erk	7422	5594	Gene	Gene	regulation|compound|START_ENTITY dependent|nsubj|regulation dependent|nmod|extra-cellular_signals_regulated_kinases extra-cellular_signals_regulated_kinases|appos|END_ENTITY	Sp3-mediated VEGF regulation is dependent on phosphorylation by extra-cellular_signals_regulated_kinases -LRB- Erk -RRB- .
20373895	0	VEGF	71,75	Et-1	28,32	VEGF	Et-1	7422	1906	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY END_ENTITY|appos|vascular_endothelial_growth_factor	Aqueous_humor_endothelin-1 -LRB- Et-1 -RRB- , vascular_endothelial_growth_factor -LRB- VEGF -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- levels in Mexican glaucomatous patients .
12428103	0	VEGF	170,174	FGF-2	123,128	VEGF	FGF-2	7422	2247	Gene	Gene	fibroblast_growth_factor-2|appos|START_ENTITY fibroblast_growth_factor-2|appos|END_ENTITY	Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
15078481	0	VEGF	44,48	FGF-2	93,98	VEGF	FGF-2	22339(Tax:10090)	14173(Tax:10090)	Gene	Gene	acts|amod|START_ENTITY acts|nmod|substitute substitute|nmod|END_ENTITY	Liver_regeneration in FGF-2-deficient mice : VEGF acts as potential functional substitute for FGF-2 .
15367264	0	VEGF	93,97	FGF-2	178,183	VEGF	FGF-2	281572(Tax:9913)	281161(Tax:9913)	Gene	Gene	factor|dep|START_ENTITY factor|nmod|END_ENTITY	Expression pattern of fibroblast growth factor -LRB- FGF -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- system members in bovine corpus luteum endothelial cells during treatment with FGF-2 , VEGF or oestradiol .
18948122	0	VEGF	0,4	FGF-2	15,20	VEGF	FGF-2	281572(Tax:9913)	281161(Tax:9913)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	VEGF regulates FGF-2 and TGF-beta1 expression in injury endothelial cells and mediates smooth muscle cells proliferation and migration .
9647657	0	VEGF	79,83	FGF-2	28,33	VEGF	FGF-2	22339(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY induces|dobj|expression induces|nsubj|Fibroblast_growth_factor-2 Fibroblast_growth_factor-2|appos|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the endothelial cells of forming capillaries : an autocrine mechanism contributing to angiogenesis .
10194760	0	VEGF	121,125	FLT-1	70,75	VEGF	FLT-1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity important|nmod|regulation R1|acl:relcl|important R1|appos|END_ENTITY	Alternative splicing of vascular_endothelial_growth_factor _ -LRB- VEGF -RRB- - R1 -LRB- FLT-1 -RRB- pre-mRNA is important for the regulation of VEGF activity .
10544000	0	VEGF	76,80	FLT-1	67,72	VEGF	FLT-1	7422	2321	Gene	Gene	receptor|amod|START_ENTITY loop|appos|receptor loop|nmod|domain domain|nmod|END_ENTITY	The fourth immunoglobulin-like loop in the extracellular domain of FLT-1 , a VEGF receptor , includes a major heparin-binding site .
11817706	0	VEGF	61,65	FLT-1	90,95	VEGF	FLT-1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Monoclonal antibodies to vascular_endothelial_growth_factor -LRB- VEGF -RRB- and the VEGF receptor , FLT-1 , inhibit the growth of C6_glioma in a mouse xenograft .
12560388	0	VEGF	75,79	FLT-1	99,104	VEGF	FLT-1	7422	2321	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression and prognostic relevance of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor -LRB- FLT-1 -RRB- in nephroblastoma .
14987558	0	VEGF	17,21	FLT-1	34,39	VEGF	FLT-1	7422	2321	Gene	Gene	receptor-1|compound|START_ENTITY Functions|nmod|receptor-1 Functions|appos|END_ENTITY	Functions of the VEGF receptor-1 -LRB- FLT-1 -RRB- in the vasculature .
21860419	0	VEGF	17,21	FOXO3a	0,6	VEGF	FOXO3a	7422	2309	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	FOXO3a represses VEGF expression through FOXM1-dependent and - independent mechanisms in breast_cancer .
19625659	0	VEGF	44,48	Fatty_acid_binding_protein_4	0,28	VEGF	Fatty acid binding protein 4	7422	2167	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Fatty_acid_binding_protein_4 is a target of VEGF and a regulator of cell proliferation in endothelial cells .
10066445	0	VEGF	0,4	Flk-1	38,43	VEGF	Flk-1	7422	3791	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|cells cells|compound|KDR KDR|compound|END_ENTITY	VEGF induces nuclear translocation of Flk-1 / KDR , endothelial_nitric_oxide_synthase , and caveolin-1 in vascular endothelial cells .
12226078	0	VEGF	55,59	Flk-1	70,75	VEGF	Flk-1	281572(Tax:9913)	407170(Tax:9913)	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY END_ENTITY|amod|vascular_endothelial_growth_factor	Transactivation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR is involved in sphingosine_1-phosphate-stimulated phosphorylation of Akt and endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- .
12549858	0	VEGF	34,38	Flk-1	101,106	VEGF	Flk-1	7422	3791	Gene	Gene	binding|nsubj|START_ENTITY blocks|xcomp|binding antibody|acl:relcl|blocks inhibits|nsubj|antibody inhibits|dobj|expression expression|nmod|growth growth|compound|END_ENTITY	A monoclonal antibody that blocks VEGF binding to VEGFR2 -LRB- KDR/Flk -1 -RRB- inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast_cancer model .
15111299	0	VEGF	40,44	Flk-1	81,86	VEGF	Flk-1	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	Flt-1|appos|START_ENTITY modulates|nsubj|Flt-1 modulates|dobj|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
16394178	0	VEGF	54,58	Flk-1	69,74	VEGF	Flk-1	7422	3791	Gene	Gene	receptor|appos|START_ENTITY Regulation|nmod|receptor END_ENTITY|nsubj|Regulation	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
17765237	0	VEGF	73,77	Flk-1	105,110	VEGF	Flk-1	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular density and distribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor VEGFR-2 -LRB- Flk-1 -RRB- are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum .
20085636	0	VEGF	57,61	Flk-1	89,94	VEGF	Flk-1	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Higher expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor VEGFR-2 -LRB- Flk-1 -RRB- and metalloproteinase-9 -LRB- MMP-9 -RRB- in a rat model of peritoneal endometriosis is similar to cancer_diseases .
23250775	0	VEGF	90,94	Flk-1	149,154	VEGF	Flk-1	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY analysis|nmod|vascular_endothelial_growth_factor follow-up|nmod|analysis follow-up|appos|KDR KDR|compound|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
7681362	0	VEGF	14,18	Flk-1	64,69	VEGF	Flk-1	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	binding|compound|START_ENTITY suggest|nsubj|binding suggest|dobj|END_ENTITY	High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis .
21068311	0	VEGF	51,55	Flk1	131,135	VEGF	Flk1	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY isoforms|nsubj|vascular_endothelial_growth_factor isoforms|nmod|cerebellum cerebellum|nmod|END_ENTITY	Matrix-binding vascular_endothelial_growth_factor -LRB- VEGF -RRB- isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1 .
21658588	0	VEGF	0,4	Flk1	68,72	VEGF	Flk1	7422	3791	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	VEGF mediates commissural axon chemoattraction through its receptor Flk1 .
10471394	0	VEGF	24,28	Flt-1	49,54	VEGF	Flt-1	7422	2321	Gene	Gene	site|compound|START_ENTITY site|nmod|receptor receptor|compound|END_ENTITY	Characterization of the VEGF binding site on the Flt-1 receptor .
10496528	0	VEGF	9,13	Flt-1	26,31	VEGF	Flt-1	7422	2321	Gene	Gene	VEGF|nmod|START_ENTITY VEGF|appos|END_ENTITY	VEGF via VEGF receptor-1 -LRB- Flt-1 -RRB- mimics preeclamptic plasma in inhibiting uterine blood vessel relaxation in pregnancy : implications in the pathogenesis of preeclampsia .
10815805	0	VEGF	13,17	Flt-1	29,34	VEGF	Flt-1	7422	2321	Gene	Gene	receptors|compound|START_ENTITY Roles|nmod|receptors Roles|appos|END_ENTITY	Roles of two VEGF receptors , Flt-1 and KDR , in the signal transduction of VEGF effects in human vascular endothelial cells .
10815805	0	VEGF	74,78	Flt-1	29,34	VEGF	Flt-1	7422	2321	Gene	Gene	effects|amod|START_ENTITY transduction|nmod|effects Roles|nmod|transduction Roles|appos|END_ENTITY	Roles of two VEGF receptors , Flt-1 and KDR , in the signal transduction of VEGF effects in human vascular endothelial cells .
10865839	0	VEGF	18,22	Flt-1	34,39	VEGF	Flt-1	7422	2321	Gene	Gene	receptors|compound|START_ENTITY Properties|nmod|receptors Properties|appos|END_ENTITY	Properties of two VEGF receptors , Flt-1 and KDR , in signal transduction .
12553021	0	VEGF	50,54	Flt-1	75,80	VEGF	Flt-1	7422	2321	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|dep|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- Flt-1 and Flk-1 -RRB- in esophageal_squamous_cell_carcinoma .
15297261	0	VEGF	29,33	Flt-1	51,56	VEGF	Flt-1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY transfer|nmod|receptor transfer|appos|END_ENTITY	The gene transfer of soluble VEGF type I receptor -LRB- Flt-1 -RRB- attenuates peritoneal fibrosis formation in mice but not soluble TGF-beta_type_II_receptor gene transfer .
15492987	0	VEGF	50,54	Flt-1	84,89	VEGF	Flt-1	7422	2321	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|dep|-RSB- -RSB-|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
15851564	0	VEGF	43,47	Flt-1	0,5	VEGF	Flt-1	7422	2321	Gene	Gene	expression|amod|START_ENTITY inhibit|dobj|expression inhibit|nsubj|intraceptors intraceptors|amod|END_ENTITY	Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal_neovascularization in vivo .
16530326	0	VEGF	47,51	Flt-1	33,38	VEGF	Flt-1	7422	2321	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|mRNA mRNA|compound|END_ENTITY	The ratio of membrane-bound form Flt-1 mRNA to VEGF mRNA correlates with tumor angiogenesis and prognosis in non-small_cell_lung_cancer .
17031660	0	VEGF	56,60	Flt-1	100,105	VEGF	Flt-1	100462897	100732326	Gene	Gene	expression|appos|START_ENTITY alterations|nmod|expression alterations|dep|END_ENTITY	Fast alterations of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and that of its receptors -LRB- Flt-1 , Flk-1 and Neuropilin -RRB- in the cochlea of guinea_pigs after moderate noise exposure .
18630531	0	VEGF	66,70	Flt-1	23,28	VEGF	Flt-1	7422	2321	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|Expression Expression|nmod|VEGFR-1 VEGFR-1|appos|END_ENTITY	Expression of VEGFR-1 -LRB- Flt-1 -RRB- in breast_cancer is associated with VEGF expression and with node-negative tumour stage .
18726395	0	VEGF	55,59	Flt-1	70,75	VEGF	Flt-1	7422	2321	Gene	Gene	Screening|appos|START_ENTITY receptor|nsubj|Screening receptor|dobj|domain domain|compound|END_ENTITY	Screening of human vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 domain and study on its biological activity .
19528353	0	VEGF	45,49	Flt-1	51,56	VEGF	Flt-1	7422	2321	Gene	Gene	expressions|amod|START_ENTITY expressions|amod|END_ENTITY	Decreased nephrin and GLEPP-1 , but increased VEGF , Flt-1 , and nitrotyrosine , expressions in kidney tissue sections from women with preeclampsia .
20607359	0	VEGF	47,51	Flt-1	23,28	VEGF	Flt-1	7422	2321	Gene	Gene	receptor|compound|START_ENTITY acted|nmod|receptor acted|nsubj|fragment fragment|nmod|END_ENTITY	A fusion fragment from Flt-1 and KDR , acted as VEGF decoy receptor and exhibited anti-tumor function .
21515041	0	VEGF	39,43	Flt-1	56,61	VEGF	Flt-1	7422	2321	Gene	Gene	receptor-1|nsubj|START_ENTITY utilizing|xcomp|receptor-1 biosensor|dep|utilizing biosensor|appos|END_ENTITY	A new impedimetric biosensor utilizing VEGF receptor-1 -LRB- Flt-1 -RRB- : early diagnosis of vascular_endothelial_growth_factor in breast_cancer .
21558755	0	VEGF	22,26	Flt-1	15,20	VEGF	Flt-1	7422	2321	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Flt-1 -LRB- VEGF receptor-1 -RRB- in cancer and preeclampsia .
9393862	0	VEGF	41,45	Flt-1	78,83	VEGF	Flt-1	7422	2321	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|domain domain|nmod|receptor receptor|compound|END_ENTITY	Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor .
21724588	0	VEGF	16,20	GPR56	0,5	VEGF	GPR56	7422	9289	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	GPR56 Regulates VEGF production and angiogenesis during melanoma progression .
16941962	0	VEGF	47,51	GRO-1	15,20	VEGF	GRO-1	7422	2919	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of GRO-1 and its relationship with VEGF in squamous_cell_carcinoma of larynx -RSB- .
26104651	1	VEGF	107,111	GRP78	87,92	VEGF	GRP78	7422	3309	Gene	Gene	START_ENTITY|nsubj|Changes Changes|nmod|END_ENTITY	Changes of GRP78 and placental VEGF in preeclampsia .
23379999	0	VEGF	35,39	G_protein-coupled_receptor_91	104,133	VEGF	G protein-coupled receptor 91	83785(Tax:10116)	408199(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY release|nsubj|Inhibition release|nmod|END_ENTITY	Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G_protein-coupled_receptor_91 .
20443868	0	VEGF	23,27	G_protein-coupled_receptor_kinase_5	84,119	VEGF	G protein-coupled receptor kinase 5	7422	2869	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of VEGF signaling in human coronary artery endothelial cells by G_protein-coupled_receptor_kinase_5 .
20543462	0	VEGF	45,49	GnRH_II	10,17	VEGF	GnRH II	7422	2797	Gene	Gene	secretion|nmod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of GnRH_II and GnRH_I on secretion of VEGF by eutopic and ectopic endometrial stromal cells of endometriosis patients .
18617643	0	VEGF	0,4	HDAC7	16,21	VEGF	HDAC7	7422	51564	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis .
20072693	0	VEGF	14,18	HGF	20,23	VEGF	HGF	7422	3082	Gene	Gene	MMP-9|compound|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
14715242	0	VEGF	40,44	HIF-1	78,83	VEGF	HIF-1	7422	3091	Gene	Gene	prostaglandin-J2|nmod|START_ENTITY effects|nmod|prostaglandin-J2 effects|dep|role role|nmod|END_ENTITY	Opposite effects of prostaglandin-J2 on VEGF in normoxia and hypoxia : role of HIF-1 .
15665520	0	VEGF	0,4	HIF-1	78,83	VEGF	HIF-1	7422	3091	Gene	Gene	production|amod|START_ENTITY production|dep|requirement requirement|nmod|signaling signaling|amod|END_ENTITY	VEGF production by primary human renal proximal tubular cells : requirement of HIF-1 , PI3-kinase and MAPKK-1 signaling .
17268888	0	VEGF	74,78	HIF-1	29,34	VEGF	HIF-1	7422	3091	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	The hypoxia-inducible factor HIF-1 promotes intramyocardial expression of VEGF in infants with congenital cardiac_defects .
20423107	0	VEGF	106,110	HIF-1	100,105	VEGF	HIF-1	7422	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1 / VEGF pathway .
23049945	0	VEGF	52,56	HIF-1	74,79	VEGF	HIF-1	7422	3091	Gene	Gene	independently|compound|START_ENTITY independently|nmod|END_ENTITY	Activation of protease-activated_receptor_2 induces VEGF independently of HIF-1 .
24347168	0	VEGF	199,203	HIF-1	115,120	VEGF	HIF-1	7422	3091	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY targets|nmod|vascular_endothelial_growth_factor activity|nmod|targets activity|compound|END_ENTITY	Endoplasmic reticulum -LRB- ER -RRB- stress and hypoxia response pathways interact to potentiate hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- transcriptional activity on targets like vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
26193287	0	VEGF	90,94	HIF-1	84,89	VEGF	HIF-1	7422	3091	Gene	Gene	Signaling|compound|START_ENTITY Angiogenesis|dep|Signaling Angiogenesis|nmod|END_ENTITY	Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1 / VEGF Signaling under Hypoxia .
12646199	0	VEGF	94,98	HIF-1_alpha	54,65	VEGF	HIF-1 alpha	7422	3091	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Dibenzoylmethane , a natural dietary compound , induces HIF-1_alpha and increases expression of VEGF .
15135139	0	VEGF	14,18	HIF-1_alpha	84,95	VEGF	HIF-1 alpha	22339(Tax:10090)	15251(Tax:10090)	Gene	Gene	isoforms|amod|START_ENTITY Expression|nmod|isoforms dependent|nsubj|Expression dependent|advmod|END_ENTITY	Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1_alpha dependent .
15277511	0	VEGF	14,18	HIF-1_alpha	67,78	VEGF	HIF-1 alpha	7422	3091	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|expression expression|compound|END_ENTITY	IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1_alpha expression and activity in retinal pigment epithelial cell line D407 .
17947829	0	VEGF	14,18	HIF-1_alpha	43,54	VEGF	HIF-1 alpha	7422	3091	Gene	Gene	Inhibition|nmod|START_ENTITY expression|nsubj|Inhibition expression|advcl|targeting targeting|dobj|END_ENTITY	Inhibition of VEGF expression by targeting HIF-1_alpha with small interference RNA in human RPE cells .
20232316	0	VEGF	18,22	HIF-1_alpha	47,58	VEGF	HIF-1 alpha	7422	3091	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	miR-20b modulates VEGF expression by targeting HIF-1_alpha and STAT3 in MCF-7 breast_cancer cells .
20827786	0	VEGF	61,65	HIF-1a	0,6	VEGF	HIF-1a	22339(Tax:10090)	15251(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY allergic_airway_disease|nmod|suppression ameliorates|dobj|allergic_airway_disease ameliorates|nsubj|inhibition inhibition|amod|END_ENTITY	HIF-1a inhibition ameliorates an allergic_airway_disease via VEGF suppression in bronchial epithelium .
21479433	0	VEGF	32,36	HIF-1a	50,56	VEGF	HIF-1a	7422	3091	Gene	Gene	reduction|nmod|START_ENTITY secretion|nsubj|reduction secretion|nmod|degradation degradation|compound|END_ENTITY	Zebularine-induced reduction in VEGF secretion by HIF-1a degradation in oral_squamous_cell_carcinoma .
22004076	0	VEGF	22,26	HIF-1a	41,47	VEGF	HIF-1a	7422	3091	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	A novel regulation of VEGF expression by HIF-1a and STAT3 in HDM2 transfected prostate_cancer cells .
22300081	0	VEGF	43,47	HIF-1a	33,39	VEGF	HIF-1a	7422	3091	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Critical role of hypoxia sensor -- HIF-1a in VEGF gene activation .
22511848	0	VEGF	14,18	HIF-1a	80,86	VEGF	HIF-1a	22339(Tax:10090)	15251(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of VEGF expression and corneal_neovascularization by shRNA targeting HIF-1a in a mouse model of closed eye contact_lens wear .
22546754	0	VEGF	7,11	HIF-1a	0,6	VEGF	HIF-1a	7422	3091	Gene	Gene	signaling|compound|START_ENTITY play|nsubj|signaling END_ENTITY|parataxis|play	HIF-1a / VEGF signaling pathway may play a dual role in secondary pathogenesis of cervical myelopathy .
22649212	0	VEGF	95,99	HIF-1a	88,94	VEGF	HIF-1a	7422	3091	Gene	Gene	START_ENTITY|amod|miR-23b miR-23b|nmod|survival survival|nmod|suppression suppression|nmod|END_ENTITY	VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1a / VEGF and b-catenin/Tcf -4 signaling .
22771629	0	VEGF	62,66	HIF-1a	46,52	VEGF	HIF-1a	7422	3091	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|mediated mediated|amod|END_ENTITY	Notoginsenoside_Ft1 promotes angiogenesis via HIF-1a mediated VEGF secretion and the regulation of PI3K/AKT and Raf/MEK/ERK signaling pathways .
22932708	0	VEGF	81,85	HIF-1a	69,75	VEGF	HIF-1a	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY HO-1|appos|signaling HO-1|dep|exerts exerts|dobj|effect effect|acl|activating activating|dobj|END_ENTITY	M3-mAChR stimulation exerts anti-apoptotic effect via activating the HIF-1a / HO-1 / VEGF signaling pathway in H9c2 rat ventricular cells .
22970342	0	VEGF	14,18	HIF-1a	33,39	VEGF	HIF-1a	397157(Tax:9823)	396696(Tax:9823)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of VEGF expression by HIF-1a in the femoral_head_cartilage following ischemia_osteonecrosis .
23096096	0	VEGF	16,20	HIF-1a	67,73	VEGF	HIF-1a	7422	3091	Gene	Gene	expression|compound|START_ENTITY Upregulation|nmod|expression associated|nsubjpass|Upregulation associated|nmod|accumulation accumulation|nmod|END_ENTITY	Upregulation of VEGF expression is associated with accumulation of HIF-1a in the skin of na ve scleroderma patients .
23185615	0	VEGF	58,62	HIF-1a	96,102	VEGF	HIF-1a	22339(Tax:10090)	15251(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Peroxiredoxin_1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1a .
23279259	0	VEGF	24,28	HIF-1a	30,36	VEGF	HIF-1a	7422	3091	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Microvessel density and VEGF , HIF-1a expression in primary oral_melanoma : correlation with prognosis .
23326384	0	VEGF	0,4	HIF-1a	6,12	VEGF	HIF-1a	7422	3091	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	VEGF , HIF-1a expression and MVD as an angiogenic network in familial breast_cancer .
23416116	0	VEGF	74,78	HIF-1a	67,73	VEGF	HIF-1a	7422	3091	Gene	Gene	signaling|nsubj|START_ENTITY angiogenesis|parataxis|signaling angiogenesis|nmod|END_ENTITY	Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1a / VEGF signaling pathway in human bladder_cancer cells .
23791618	0	VEGF	140,144	HIF-1a	133,139	VEGF	HIF-1a	7422	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	The radiosensitizing effect of CpG ODN107 on human glioma cells is tightly related to its antiangiogenic activity via suppression of HIF-1a / VEGF pathway .
23869238	0	VEGF	50,54	HIF-1a	43,49	VEGF	HIF-1a	7422	3091	Gene	Gene	Signaling|compound|START_ENTITY hTERT|dep|Signaling hTERT|appos|NF-kB/COX NF-kB/COX|nummod|END_ENTITY	Berberine Targets AP-2 / hTERT , NF-kB/COX -2 , HIF-1a / VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth .
23947803	0	VEGF	49,53	HIF-1a	0,6	VEGF	HIF-1a	7422	3091	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression END_ENTITY|parataxis|mediates	HIF-1a / GPER signaling mediates the expression of VEGF induced by hypoxia in breast_cancer associated fibroblasts -LRB- CAFs -RRB- .
24098549	0	VEGF	41,45	HIF-1a	65,71	VEGF	HIF-1a	22339(Tax:10090)	15251(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulate|dobj|expression stimulate|nmod|END_ENTITY	Fumaric_acid_esters stimulate astrocytic VEGF expression through HIF-1a and Nrf2 .
25405167	0	VEGF	75,79	HIF-1a	0,6	VEGF	HIF-1a	7422	3091	Gene	Gene	expression|amod|START_ENTITY regulating|dobj|expression growth|acl|regulating regulated|dobj|growth regulated|nsubj|END_ENTITY	HIF-1a regulated tongue_squamous_cell_carcinoma cell growth via regulating VEGF expression in a xenograft model .
25945035	0	VEGF	74,78	HIF-1a	67,73	VEGF	HIF-1a	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	stimulates|amod|START_ENTITY stimulates|dep|Promoting Promoting|nmod|END_ENTITY	Promoting endothelial function by S-nitrosoglutathione through the HIF-1a / VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats .
25945035	0	VEGF	74,78	HIF-1a	67,73	VEGF	HIF-1a	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	stimulates|amod|START_ENTITY stimulates|dep|Promoting Promoting|nmod|END_ENTITY	Promoting endothelial function by S-nitrosoglutathione through the HIF-1a / VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats .
25955241	0	VEGF	31,35	HIF-1a	59,65	VEGF	HIF-1a	7422	3091	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nmod|pathways pathways|amod|END_ENTITY	3,3 ' - Diindolylmethane inhibits VEGF expression through the HIF-1a and NF-kB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions .
26345811	0	VEGF	17,21	HIF-1a	10,16	VEGF	HIF-1a	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY Effect|parataxis|signaling Effect|nmod|END_ENTITY	Effect of HIF-1a / VEGF signaling pathway on plasma progesterone and ovarian prostaglandin_F2a secretion during luteal development of pseudopregnant rats .
26345811	0	VEGF	17,21	HIF-1a	10,16	VEGF	HIF-1a	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY Effect|parataxis|signaling Effect|nmod|END_ENTITY	Effect of HIF-1a / VEGF signaling pathway on plasma progesterone and ovarian prostaglandin_F2a secretion during luteal development of pseudopregnant rats .
26537366	0	VEGF	34,38	HIF-1a	27,33	VEGF	HIF-1a	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	signaling|nsubj|START_ENTITY Wnt/b-catenin|parataxis|signaling Wnt/b-catenin|acl|coupled coupled|nmod|END_ENTITY	Wnt/b-catenin coupled with HIF-1a / VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral_ischemia .
26882120	0	VEGF	129,133	HIF-1a	25,31	VEGF	HIF-1a	7422	3091	Gene	Gene	Secretion|compound|START_ENTITY Regulation|nmod|Secretion Involved|nmod|Regulation Involved|nsubjpass|Up-Regulation Up-Regulation|nmod|ENO1 ENO1|nmod|END_ENTITY	Up-Regulation of ENO1 by HIF-1a in Retinal Pigment Epithelial Cells after Hypoxic Challenge Is Not Involved in the Regulation of VEGF Secretion .
26942921	0	VEGF	84,88	HIF-1a	77,83	VEGF	HIF-1a	7422	3091	Gene	Gene	signals|compound|START_ENTITY signals|amod|END_ENTITY	Valproic_acid inhibits the angiogenic potential of cervical_cancer cells via HIF-1a / VEGF signals .
26987747	0	VEGF	34,38	HIF-1a	17,23	VEGF	HIF-1a	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	modulates|xcomp|START_ENTITY modulates|nsubj|Stabilization Stabilization|nmod|END_ENTITY	Stabilization of HIF-1a modulates VEGF and caspase-3 in hippocampus of rats following transient global ischemia induced by asphyxial cardiac_arrest .
12709416	0	VEGF	101,105	HIF-1alpha	90,100	VEGF	HIF-1alpha	7422	3091	Gene	Gene	exposure|dep|START_ENTITY exposure|dep|impairment impairment|nmod|END_ENTITY	Inhibition of hypoxia-induced angiogenesis by cigarette smoke exposure : impairment of the HIF-1alpha / VEGF pathway .
14613646	0	VEGF	120,124	HIF-1alpha	51,61	VEGF	HIF-1alpha	7422	3091	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY Relationship|nmod|vascular_endothelial_growth_factor Relationship|nmod|expression expression|amod|hypoxia-inducible_factor_1_alpha hypoxia-inducible_factor_1_alpha|dep|END_ENTITY	-LSB- Relationship of hypoxia-inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- gene expression with vascular_endothelial_growth_factor -LRB- VEGF -RRB- and microvessel density -LRB- MVD -RRB- in human colorectal_adenoma and adenocarcinoma -RSB- .
15388333	0	VEGF	38,42	HIF-1alpha	122,132	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|nmod|START_ENTITY suppresses|dobj|expression suppresses|nmod|cells cells|nmod|degradation degradation|nmod|protein protein|compound|END_ENTITY	Apigenin suppresses the expression of VEGF , an important factor for angiogenesis , in endothelial cells via degradation of HIF-1alpha protein .
15542432	0	VEGF	66,70	HIF-1alpha	8,18	VEGF	HIF-1alpha	7422	3091	Gene	Gene	loop|compound|START_ENTITY necessary|nsubj|loop disrupts|xcomp|necessary disrupts|nsubj|Loss Loss|nmod|END_ENTITY	Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis .
15583935	0	VEGF	163,167	HIF-1alpha	115,125	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|appos|START_ENTITY effects|dep|expression effects|dep|inhibition inhibition|nmod|hypoxia-inducible_factor_1_alpha hypoxia-inducible_factor_1_alpha|appos|END_ENTITY	Anti-angiogenic effects of SN38 -LRB- active metabolite of irinotecan -RRB- : inhibition of hypoxia-inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- / vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression of glioma and growth of endothelial cells .
15705785	0	VEGF	74,78	HIF-1alpha	134,144	VEGF	HIF-1alpha	22339(Tax:10090)	15251(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY expression|nmod|vascular_endothelial_growth_factor enhances|dobj|expression enhances|nmod|induction induction|nmod|END_ENTITY	Thrombopoietin enhances expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in primitive hematopoietic cells through induction of HIF-1alpha .
15735682	0	VEGF	145,149	HIF-1alpha	0,10	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression complex|acl:relcl|regulates components|nmod|complex END_ENTITY|parataxis|components	HIF-1alpha , STAT3 , CBP/p300 and Ref-1 / APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic_and_prostate_carcinomas .
15958522	0	VEGF	37,41	HIF-1alpha	11,21	VEGF	HIF-1alpha	22339(Tax:10090)	15251(Tax:10090)	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer .
16050135	0	VEGF	47,51	HIF-1alpha	89,99	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|amod|START_ENTITY suppresses|dobj|expression suppresses|nmod|downregulation downregulation|nmod|END_ENTITY	Mutant IkappaBalpha suppresses hypoxia-induced VEGF expression through downregulation of HIF-1alpha and COX-2 in human glioma cells .
16598437	0	VEGF	114,118	HIF-1alpha	80,90	VEGF	HIF-1alpha	7422	3091	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Antiangiogenic effect of 2-benzoyl-phenoxy_acetamide in EAT cell is mediated by HIF-1alpha and down regulation of VEGF of in-vivo .
16612574	0	VEGF	105,109	HIF-1alpha	47,57	VEGF	HIF-1alpha	7422	3091	Gene	Gene	growth|dep|START_ENTITY vascular_endothelial_growth_factor|xcomp|growth vascular_endothelial_growth_factor|nsubj|Inhibition Inhibition|nmod|decreases decreases|appos|END_ENTITY	Inhibition of hypoxia_inducible_factor-1alpha -LRB- HIF-1alpha -RRB- decreases vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion and tumor growth in malignant_gliomas .
16718928	0	VEGF	127,131	HIF-1alpha	90,100	VEGF	HIF-1alpha	7422	3091	Gene	Gene	promoter|compound|START_ENTITY site|nmod|promoter site|compound|END_ENTITY	Inhibition of the VEGF expression and cell growth in hepatocellular_carcinoma by blocking HIF-1alpha and Smad3 binding site in VEGF promoter .
16718928	0	VEGF	18,22	HIF-1alpha	90,100	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|hepatocellular_carcinoma hepatocellular_carcinoma|acl|blocking blocking|dobj|site site|compound|END_ENTITY	Inhibition of the VEGF expression and cell growth in hepatocellular_carcinoma by blocking HIF-1alpha and Smad3 binding site in VEGF promoter .
17442277	0	VEGF	35,39	HIF-1alpha	68,78	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|amod|START_ENTITY inhibited|dobj|expression inhibited|advcl|inducing inducing|dobj|degradation degradation|compound|END_ENTITY	Benzo -LSB- a -RSB- pyrene-3 ,6 - dione inhibited VEGF expression through inducing HIF-1alpha degradation .
18027712	0	VEGF	19,23	HIF-1alpha	46,56	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression -LSB-|dobj|inhibition induced|csubj|-LSB- induced|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The inhibition of VEGF expression induced by HIF-1alpha RNA interference -RSB- .
18452596	0	VEGF	94,98	HIF-1alpha	34,44	VEGF	HIF-1alpha	7422	3091	Gene	Gene	START_ENTITY|nsubj|significance significance|nmod|END_ENTITY	Clinicopathologic significance of HIF-1alpha , p53 , and VEGF expression and preoperative serum VEGF level in gastric_cancer .
19131542	0	VEGF	28,32	HIF-1alpha	57,67	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|amod|START_ENTITY expression|acl|reducing reducing|dobj|expression expression|compound|END_ENTITY	Grape_seed_extract inhibits VEGF expression via reducing HIF-1alpha protein expression .
19569175	0	VEGF	94,98	HIF-1alpha	83,93	VEGF	HIF-1alpha	7422	3091	Gene	Gene	signaling|nsubj|START_ENTITY angiogenesis|parataxis|signaling angiogenesis|nmod|END_ENTITY	Bisphosphonates suppress insulin-like_growth_factor_1-induced angiogenesis via the HIF-1alpha / VEGF signaling pathways in human breast_cancer cells .
20353560	0	VEGF	111,115	HIF-1alpha	29,39	VEGF	HIF-1alpha	7422	3091	Gene	Gene	reduction|nmod|START_ENTITY Expression|dep|reduction Expression|nmod|END_ENTITY	Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions ; significant reduction of VEGF by CaMKII inhibitor .
20724477	0	VEGF	25,29	HIF-1alpha	155,165	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nmod|level level|nmod|protein protein|compound|END_ENTITY	Carbon_monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms , translational activation and stabilization of HIF-1alpha protein .
20724477	0	VEGF	25,29	HIF-1alpha	55,65	VEGF	HIF-1alpha	7422	3091	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nmod|level level|compound|END_ENTITY	Carbon_monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms , translational activation and stabilization of HIF-1alpha protein .
21576240	0	VEGF	150,154	HIF-1alpha	98,108	VEGF	HIF-1alpha	7422	3091	Gene	Gene	increase|appos|START_ENTITY increase|nmod|END_ENTITY	Aldose reductase inhibition prevents hypoxia-induced increase in hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- by regulating 26 S proteasome-mediated protein degradation in human colon_cancer cells .
14712484	0	VEGF	27,31	HIF1alpha	33,42	VEGF	HIF1alpha	7422	3091	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Differential regulation of VEGF , HIF1alpha and angiopoietin-1 , _ -2 _ and _ -4 by hypoxia and ionizing radiation in human glioblastoma .
15050899	0	VEGF	67,71	HO-1	73,77	VEGF	HO-1	83785(Tax:10116)	24451(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Activation of the transcription factor HIF-1 and its target genes , VEGF , HO-1 , iNOS , during fracture repair .
15596152	0	VEGF	54,58	HO-1	80,84	VEGF	HO-1	22339(Tax:10090)	15368(Tax:10090)	Gene	Gene	heme_oxygenase-1|nmod|START_ENTITY synthesis|amod|heme_oxygenase-1 Role|nmod|synthesis Role|dep|effect effect|nmod|knockout knockout|compound|END_ENTITY	Role of heme_oxygenase-1 in hydrogen_peroxide-induced VEGF synthesis : effect of HO-1 knockout .
18937073	0	VEGF	74,78	HO-1	35,39	VEGF	HO-1	83785(Tax:10116)	24451(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY upregulation|nmod|levels expression|nmod|upregulation expression|compound|END_ENTITY	Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells .
23088309	0	VEGF	114,118	HO-1	127,131	VEGF	HO-1	22339(Tax:10090)	15368(Tax:10090)	Gene	Gene	producing|dobj|START_ENTITY producing|nmod|induction induction|compound|END_ENTITY	-LRB- S -RRB- -1 - a-naphthylmethyl-6 ,7 - dihydroxy-1 ,2,3,4 - tetrahydroisoquinoline -LRB- CKD712 -RRB- , promotes wound closure by producing VEGF through HO-1 induction in human dermal fibroblasts and mouse skin .
22445886	0	VEGF	0,4	Homer_1a	17,25	VEGF	Homer 1a	7422	9456	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	VEGF upregulates Homer_1a gene expression via the mitogen-activated protein kinase cascade in cultured cortex neurons .
17855507	0	VEGF	89,93	Hsp90	32,37	VEGF	Hsp90	7422	3326	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Src-mediated phosphorylation of Hsp90 in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- is required for VEGF receptor-2 signaling to endothelial_NO_synthase .
10393052	0	VEGF	0,4	ICAM-1	32,38	VEGF	ICAM-1	7422	3383	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	VEGF increases retinal vascular ICAM-1 expression in vivo .
10793084	0	VEGF	36,40	ICAM-1	130,136	VEGF	ICAM-1	83785(Tax:10116)	25464(Tax:10116)	Gene	Gene	Vascular_endothelial_growth_factor|appos|START_ENTITY Vascular_endothelial_growth_factor|dep|permeability permeability|acl:relcl|mediated mediated|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced retinal_vascular permeability is mediated by intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- .
24940033	0	VEGF	111,115	ICAM-1	14,20	VEGF	ICAM-1	7422	3383	Gene	Gene	stimulation|amod|START_ENTITY mediated|nmod|stimulation mediated|nsubjpass|expression expression|compound|END_ENTITY	TNF-a-induced ICAM-1 expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation .
22776750	0	VEGF	59,63	IGF-I	35,40	VEGF	IGF-I	7422	3479	Gene	Gene	AMH|appos|START_ENTITY AMH|compound|END_ENTITY	Follicular fluid concentrations of IGF-I , IGF-II , IGFBP-3 , VEGF , AMH , and inhibin-B in women undergoing controlled ovarian_hyperstimulation using GnRH agonist or GnRH antagonist .
9582085	0	VEGF	152,156	IGF-I	105,110	VEGF	IGF-I	83785(Tax:10116)	24482(Tax:10116)	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Sex hormone-induced prostatic_carcinogenesis in the noble rat : the role of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the development of prostate_cancer .
21750048	0	VEGF	17,21	IGFBP-2	0,7	VEGF	IGFBP-2	7422	3485	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	IGFBP-2 enhances VEGF gene promoter activity and consequent promotion of angiogenesis by neuroblastoma cells .
25637316	0	VEGF	15,19	IKKb	0,4	VEGF	IKKb	7422	3551	Gene	Gene	Expression|compound|START_ENTITY Regulates|dobj|Expression Regulates|nsubj|END_ENTITY	IKKb Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Antiangiogenic Treatment .
15325633	0	VEGF	40,44	IL-17	0,5	VEGF	IL-17	7422	3605	Gene	Gene	production|amod|START_ENTITY stimulate|dobj|production stimulate|nsubj|END_ENTITY	IL-17 , IL-1beta and TNF-alpha stimulate VEGF production by dedifferentiated chondrocytes .
25613064	0	VEGF	27,31	IL-17F	6,12	VEGF	IL-17F	7422	112744	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|END_ENTITY	Serum IL-17F combined with VEGF as potential diagnostic biomarkers for oral_squamous_cell_carcinoma .
11040101	0	VEGF	13,17	IL-1_beta	40,49	VEGF	IL-1 beta	83785(Tax:10116)	24494(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Induction of VEGF gene transcription by IL-1_beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes .
12792892	0	VEGF	52,56	IL-1beta	126,134	VEGF	IL-1beta	22339(Tax:10090)	16176(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY Upregulation|nmod|vascular_endothelial_growth_factor overexpressing|nsubj|Upregulation overexpressing|dobj|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the retinas of transgenic_mice overexpressing interleukin-1beta -LRB- IL-1beta -RRB- in the lens and mice undergoing retinal_degeneration .
15665043	0	VEGF	20,24	IL-1beta	79,87	VEGF	IL-1beta	7422	3553	Gene	Gene	release|amod|START_ENTITY causes|dobj|release causes|parataxis|synergy synergy|nmod|END_ENTITY	Oncostatin_M causes VEGF release from human airway smooth muscle : synergy with IL-1beta .
17035941	0	VEGF	17,21	IL-1beta	0,8	VEGF	IL-1beta	7422	3553	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-1beta induces VEGF , independently of PGE2 induction , mainly through the PI3-K/mTOR pathway in renal mesangial cells .
20160089	0	VEGF	35,39	IL-33	0,5	VEGF	IL-33	7422	90865	Gene	Gene	secretion|amod|START_ENTITY augments|dobj|secretion augments|nsubj|END_ENTITY	IL-33 augments substance_P-induced VEGF secretion from human mast cells and is increased in psoriatic skin .
12553038	0	VEGF	65,69	IL-6	14,18	VEGF	IL-6	7422	3569	Gene	Gene	induction|compound|START_ENTITY involvement|nmod|induction Expression|dep|involvement Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of IL-6 receptor in pancreatic_cancer : involvement in VEGF induction .
16009363	0	VEGF	51,55	IL-6	15,19	VEGF	IL-6	7422	3569	Gene	Gene	production|nmod|START_ENTITY Involvement|nmod|production Involvement|nmod|END_ENTITY	Involvement of IL-6 in the paracrine production of VEGF in ocular_HSV-1_infection .
16875552	0	VEGF	28,32	IL-6	34,38	VEGF	IL-6	7422	3569	Gene	Gene	significance|nmod|START_ENTITY -LSB-|dobj|significance -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The significance of IGF-1 , VEGF , IL-6 in multiple_myeloma progression -RSB- .
17725274	0	VEGF	79,83	IL-6	136,140	VEGF	IL-6	7422	3569	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|interleukin_6 interleukin_6|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
20072693	0	VEGF	14,18	IL-6	25,29	VEGF	IL-6	7422	3569	Gene	Gene	MMP-9|compound|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
21633597	0	VEGF	40,44	IL-6	67,71	VEGF	IL-6	7422	3569	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	-LRB- - -RRB- - Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric_cancer .
23272057	0	VEGF	92,96	IL-6	98,102	VEGF	IL-6	7422	3569	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Hypoxia-induced aggressiveness of pancreatic_cancer cells is due to increased expression of VEGF , IL-6 and miR-21 , which can be attenuated by CDF treatment .
23788086	0	VEGF	49,53	IL-6	67,71	VEGF	IL-6	7422	3569	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Does mobilisation of CD34 + stem cells along with VEGF , angiogenin , IL-6 , IL-8 , and hsCRP levels allow predicting the direction of left ventricular ejection fraction and wall_motion_score_index changes in patients with myocardial_infarction ?
19597830	0	VEGF	30,34	IL-8	46,50	VEGF	IL-8	7422	3576	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Gingko_biloba extract reduces VEGF and CXCL-8 / IL-8 levels in keratinocytes with cumulative effect with epigallocatechin-3-gallate .
20072693	0	VEGF	14,18	IL-8	31,35	VEGF	IL-8	7422	3576	Gene	Gene	MMP-9|compound|START_ENTITY MMP-9|appos|END_ENTITY	Expression of VEGF , HGF , IL-6 , IL-8 , MMP-9 , Telomerase in Peripheral Blood of Patients with Head_and_Neck_Squamous_Cell_Carcinoma .
20156197	0	VEGF	10,14	IL-8	69,73	VEGF	IL-8	281572(Tax:9913)	280828(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of VEGF -LRB- vascular_endothelial_growth_factor -RRB- on expression of IL-8 -LRB- interleukin-8 -RRB- , IL-1beta and their receptors in bovine theca cells .
23495770	0	VEGF	82,86	IL-8	40,44	VEGF	IL-8	7422	3576	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY END_ENTITY|appos|vascular_endothelial_growth_factor	Regulatory T cells , interleukin _ -LRB- IL -RRB- -6 , IL-8 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , CXCL10 , CXCL11 , epidermal_growth_factor -LRB- EGF -RRB- and hepatocyte_growth_factor -LRB- HGF -RRB- as surrogate markers of host immunity in patients with renal_cell_carcinoma .
15745939	0	VEGF	15,19	IL1_alpha	36,45	VEGF	IL1 alpha	7422	3552	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Correlation of VEGF production with IL1_alpha and IL6 secretion by human pituitary_adenoma_cells .
16998811	0	VEGF	43,47	INK4A	64,69	VEGF	INK4A	7422	1029	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
20884890	0	VEGF	0,4	ItgaL	78,83	VEGF	ItgaL	7422	3683	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	VEGF differentially regulates neutrophil and T cell adhesion through ItgaL - and ItgaM-dependent mechanisms .
10066445	0	VEGF	0,4	KDR	44,47	VEGF	KDR	7422	3791	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|cells cells|compound|END_ENTITY	VEGF induces nuclear translocation of Flk-1 / KDR , endothelial_nitric_oxide_synthase , and caveolin-1 in vascular endothelial cells .
10748050	0	VEGF	150,154	KDR	39,42	VEGF	KDR	7422	3791	Gene	Gene	mRNAs|nmod|START_ENTITY mRNAs|nsubj|modulation modulation|nmod|END_ENTITY	Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- receptor mRNAs by VEGF .
11348872	0	VEGF	0,4	KDR	129,132	VEGF	KDR	7422	3791	Gene	Gene	protects|nsubj|START_ENTITY protects|xcomp|endothelial endothelial|nmod|receptor receptor|compound|END_ENTITY	VEGF protects against oxidized LDL toxicity to endothelial cells by an intracellular glutathione-dependent mechanism through the KDR receptor .
11349728	0	VEGF	19,23	KDR	48,51	VEGF	KDR	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Gene expression of VEGF and its receptors Flk-1 / KDR and Flt-1 in cultured and transplanted rat islets .
12052848	0	VEGF	74,78	KDR	0,3	VEGF	KDR	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY mediator|nmod|effect mediator|nsubj|END_ENTITY	KDR -LRB- VEGF receptor 2 -RRB- is the major mediator for the hypotensive effect of VEGF .
12226078	0	VEGF	55,59	KDR	76,79	VEGF	KDR	281572(Tax:9913)	407170(Tax:9913)	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY Flk-1|amod|vascular_endothelial_growth_factor Transactivation|nmod|Flk-1 Transactivation|parataxis|involved involved|nsubjpass|END_ENTITY	Transactivation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR is involved in sphingosine_1-phosphate-stimulated phosphorylation of Akt and endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- .
12665467	0	VEGF	14,18	KDR	53,56	VEGF	KDR	443103(Tax:9940)	443087(Tax:9940)	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|altered altered|nsubjpass|END_ENTITY	Expression of VEGF and its receptors Flt-1 and Flk-1 / KDR is altered in lambs with increased_pulmonary_blood_flow and pulmonary_hypertension .
12670961	0	VEGF	102,106	KDR	120,123	VEGF	KDR	7422	3791	Gene	Gene	factor|appos|START_ENTITY upstream|nmod|factor function|advmod|upstream function|dobj|phosphorylation phosphorylation|appos|END_ENTITY	Heterotrimeric G alpha q/G _ alpha_11 proteins function upstream of vascular endothelial growth factor -LRB- VEGF -RRB- receptor-2 -LRB- KDR -RRB- phosphorylation in vascular permeability factor/VEGF signaling .
12974081	0	VEGF	35,39	KDR	41,44	VEGF	KDR	7422	3791	Gene	Gene	MMP-1|compound|START_ENTITY MMP-1|appos|END_ENTITY	-LSB- Expression and significance about VEGF , KDR , MMP-1 , and transcription factor Ets-1 in human cervical_carcinoma -RSB- .
15124924	0	VEGF	49,53	KDR	82,85	VEGF	KDR	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	expressions|nmod|START_ENTITY molecules|nmod|expressions END_ENTITY|nsubj|molecules	Regulatory molecules for coronary expressions of VEGF and its angiogenic receptor KDR in hypoestrogenic middle-aged female rats .
15262130	0	VEGF	153,157	KDR	170,173	VEGF	KDR	7422	3791	Gene	Gene	transcription|nmod|START_ENTITY transducers|nmod|transcription transducers|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- and ovarian_carcinoma cell supernatant activate signal transducers and activators of transcription -LRB- STATs -RRB- via VEGF receptor-2 -LRB- KDR -RRB- in human hemopoietic progenitor cells .
15262130	0	VEGF	36,40	KDR	170,173	VEGF	KDR	7422	3791	Gene	Gene	Vascular_endothelial_growth_factor|appos|START_ENTITY activate|nsubj|Vascular_endothelial_growth_factor activate|dobj|transducers transducers|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- and ovarian_carcinoma cell supernatant activate signal transducers and activators of transcription -LRB- STATs -RRB- via VEGF receptor-2 -LRB- KDR -RRB- in human hemopoietic progenitor cells .
16010973	0	VEGF	45,49	KDR	78,81	VEGF	KDR	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY changes|nmod|expression END_ENTITY|nsubj|changes	Age-related changes in cardiac expression of VEGF and its angiogenic receptor KDR in stroke-prone spontaneously hypertensive rats .
16394178	0	VEGF	100,104	KDR	75,78	VEGF	KDR	7422	3791	Gene	Gene	Flk-1|nmod|START_ENTITY Flk-1|dobj|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16394178	0	VEGF	54,58	KDR	75,78	VEGF	KDR	7422	3791	Gene	Gene	receptor|appos|START_ENTITY Regulation|nmod|receptor Flk-1|nsubj|Regulation Flk-1|dobj|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
17382929	0	VEGF	0,4	KDR	18,21	VEGF	KDR	7422	3791	Gene	Gene	internalization|compound|START_ENTITY internalization|appos|END_ENTITY	VEGF and VEGFR-2 -LRB- KDR -RRB- internalization is required for endothelial recovery during wound healing .
19244479	0	VEGF	27,31	KDR	88,91	VEGF	KDR	7422	3791	Gene	Gene	signaling|compound|START_ENTITY attenuates|dobj|signaling attenuates|nmod|downregulation downregulation|nmod|END_ENTITY	Chronic_hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells .
19356742	0	VEGF	99,103	KDR	114,117	VEGF	KDR	7422	3791	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Stimulatory effect of Cinnamomum cassia and cinnamic_acid on angiogenesis through up-regulation of VEGF and Flk-1 / KDR expression .
19520294	0	VEGF	47,51	KDR	122,125	VEGF	KDR	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	targeted|nmod|START_ENTITY Imaging|acl|targeted exon|nsubj|Imaging exon|dobj|peptide peptide|nmod|gene gene|compound|END_ENTITY	Imaging targeted at tumor with -LRB- 188 -RRB- Re-labeled VEGF -LRB- 189 -RRB- exon 6-encoded peptide and effects of the transfecting truncated KDR gene in tumor-bearing nude_mice .
23250775	0	VEGF	90,94	KDR	155,158	VEGF	KDR	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY analysis|nmod|vascular_endothelial_growth_factor follow-up|nmod|analysis follow-up|appos|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
23393131	0	VEGF	99,103	KDR	147,150	VEGF	KDR	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY activation|amod|vascular_endothelial_growth_factor activation|appos|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
7585655	0	VEGF	54,58	KDR	75,78	VEGF	KDR	7422	3791	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor gene , KDR , in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation .
7734144	0	VEGF	0,4	KDR	23,26	VEGF	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY subtypes|nsubj|receptor subtypes|ccomp|show show|nsubj|END_ENTITY	VEGF receptor subtypes KDR and FLT1 show different sensitivities to heparin and placenta growth factor .
9386990	0	VEGF	83,87	KDR	79,82	VEGF	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Identification of a heparin binding peptide on the extracellular domain of the KDR VEGF receptor .
25100161	0	VEGF	13,17	LL37	0,4	VEGF	LL37	7422	820	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	LL37 induces VEGF expression in dental pulp cells through ERK signalling .
25230157	0	VEGF	17,21	Leptin	0,6	VEGF	Leptin	7422	3952	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Leptin increases VEGF expression and enhances angiogenesis in human chondrosarcoma cells .
15840777	0	VEGF	90,94	M-CSF	138,143	VEGF	M-CSF	22339(Tax:10090)	12977(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Effects of cyclic tensile forces on the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and macrophage-colony-stimulating_factor -LRB- M-CSF -RRB- in murine osteoblastic MC3T3-E1 cells .
18852899	0	VEGF	61,65	M-CSF	0,5	VEGF	M-CSF	7422	1435	Gene	Gene	production|amod|START_ENTITY induce|dobj|production signals|xcomp|induce signals|nsubj|END_ENTITY	M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo .
22906984	0	VEGF	0,4	M-CSF	51,56	VEGF	M-CSF	7422	1435	Gene	Gene	substitute|nsubj|START_ENTITY substitute|nmod|END_ENTITY	VEGF , FLT3_ligand , PlGF and HGF can substitute for M-CSF to induce human osteoclast formation : implications for giant_cell_tumour pathobiology .
22073279	0	VEGF	0,4	MEF2C	94,99	VEGF	MEF2C	7422	4208	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	VEGF promotes the transcription of the human PRL-3 gene in HUVEC through transcription factor MEF2C .
26090403	0	VEGF	75,79	MEG3	23,27	VEGF	MEG3	7422	55384	Gene	Gene	Levels|compound|START_ENTITY Associated|nmod|Levels Associated|nsubj|END_ENTITY	The Long Noncoding RNA MEG3 Is Downregulated and Inversely Associated with VEGF Levels in Osteoarthritis .
18003751	0	VEGF	0,4	MKP-1	25,30	VEGF	MKP-1	7422	1843	Gene	Gene	pathways|nsubj|START_ENTITY pathways|xcomp|END_ENTITY	VEGF and thrombin induce MKP-1 through distinct signaling pathways : role for MKP-1 in endothelial cell migration .
10865990	0	VEGF	89,93	MMP-2	42,47	VEGF	MMP-2	83785(Tax:10116)	81686(Tax:10116)	Gene	Gene	matrix_metalloproteinase-2|appos|START_ENTITY matrix_metalloproteinase-2|appos|END_ENTITY	Expression of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in inflammation-associated corneal_neovascularization .
17908800	0	VEGF	181,185	MMP-2	311,316	VEGF	MMP-2	22339(Tax:10090)	17390(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY disruption|nmod|vascular_endothelial_growth_factor matrix_metalloproteinase_2|dep|disruption processed|nmod|matrix_metalloproteinase_2 Identification|acl|processed Identification|parataxis|tissue_growth_factor tissue_growth_factor|nmod|proteolysis proteolysis|compound|END_ENTITY	Identification of candidate angiogenic inhibitors processed by matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in cell-based proteomic screens : disruption of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / heparin_affin_regulatory_peptide -LRB- pleiotrophin -RRB- and VEGF/Connective _ tissue_growth_factor angiogenic inhibitory complexes by MMP-2 proteolysis .
17908800	0	VEGF	181,185	MMP-2	91,96	VEGF	MMP-2	22339(Tax:10090)	17390(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY disruption|nmod|vascular_endothelial_growth_factor matrix_metalloproteinase_2|dep|disruption matrix_metalloproteinase_2|appos|END_ENTITY	Identification of candidate angiogenic inhibitors processed by matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in cell-based proteomic screens : disruption of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / heparin_affin_regulatory_peptide -LRB- pleiotrophin -RRB- and VEGF/Connective _ tissue_growth_factor angiogenic inhibitory complexes by MMP-2 proteolysis .
18829111	0	VEGF	40,44	MMP-2	13,18	VEGF	MMP-2	7422	4313	Gene	Gene	correlates|compound|START_ENTITY induced|nmod|correlates induced|nsubj|Secretion Secretion|nmod|END_ENTITY	Secretion of MMP-2 and MMP-9 induced by VEGF autocrine loop correlates with clinical features in childhood acute_lymphoblastic_leukemia .
20027628	0	VEGF	13,17	MMP-2	0,5	VEGF	MMP-2	7422	4313	Gene	Gene	expression|amod|START_ENTITY alters|dobj|expression alters|nsubj|END_ENTITY	MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung_cancer cells .
20665024	0	VEGF	104,108	MMP-2	49,54	VEGF	MMP-2	7422	4313	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|gelatinases gelatinases|amod|END_ENTITY	Expression levels and association of gelatinases MMP-2 and MMP-9 and collagenases MMP-1 and MMP-13 with VEGF in synovial fluid of patients with arthritis .
23884892	0	VEGF	0,4	MMP-2	47,52	VEGF	MMP-2	7422	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	VEGF secreted by hypoxic M ller cells induces MMP-2 expression and activity in endothelial cells to promote retinal_neovascularization in proliferative_diabetic_retinopathy .
17525740	0	VEGF	4,8	MMP-7	58,63	VEGF	MMP-7	7422	4316	Gene	Gene	switch|amod|START_ENTITY regulated|nsubjpass|switch regulated|nmod|END_ENTITY	The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells .
18974372	0	VEGF	23,27	MMP-7	42,47	VEGF	MMP-7	7422	4316	Gene	Gene	START_ENTITY|amod|receptor-1 receptor-1|nmod|END_ENTITY	Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells .
18974372	0	VEGF	55,59	MMP-7	42,47	VEGF	MMP-7	7422	4316	Gene	Gene	access|amod|START_ENTITY allows|dobj|access allows|nsubj|Degradation Degradation|nmod|VEGF VEGF|amod|receptor-1 receptor-1|nmod|END_ENTITY	Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells .
22024063	0	VEGF	65,69	MMP-7	87,92	VEGF	MMP-7	7422	4316	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Immunohistochemical study of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and matrilysin -LRB- MMP-7 -RRB- in T1 adenocarcinoma_of_the_colon_and_rectum to predict lymph node metastases or distant metastases .
16584583	0	VEGF	22,26	MMP-9	38,43	VEGF	MMP-9	7422	4318	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	-LSB- Relationship between VEGF and MMP-2 , MMP-9 in 82 patients with acute_myeloid_leukemia -RSB- .
18691882	0	VEGF	0,4	MMP-9	16,21	VEGF	MMP-9	7422	4318	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal_cancer_angiogenesis .
21442180	0	VEGF	42,46	MMP-9	31,36	VEGF	MMP-9	7422	4318	Gene	Gene	component|amod|START_ENTITY component|nsubj|END_ENTITY	Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic_ductal_adenocarcinoma .
24347177	0	VEGF	51,55	MMP2	64,68	VEGF	MMP2	7422	4313	Gene	Gene	IL-6|compound|START_ENTITY IL-6|appos|END_ENTITY	The activation of TLR7 regulates the expression of VEGF , TIMP1 , MMP2 , IL-6 , and IL-15 in Hela cells .
20021822	0	VEGF	22,26	MT1-MMP	1,8	VEGF	MT1-MMP	7422	4323	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	-LSB- MT1-MMP up-regulates VEGF expression in human breast_carcinoma MCF-7 cells and induces tumor angiogenesis -RSB- .
15456771	0	VEGF	30,34	Matrix_GLA_protein	0,18	VEGF	Matrix GLA protein	7422	4256	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Matrix_GLA_protein stimulates VEGF expression through increased transforming_growth_factor-beta1 activity in endothelial cells .
18641052	0	VEGF	65,69	Matrix_metalloproteinase-3	0,26	VEGF	Matrix metalloproteinase-3	22339(Tax:10090)	17392(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Matrix_metalloproteinase-3 enhances the free fatty_acids-induced VEGF expression in adipocytes through toll-like_receptor_2 .
18295594	0	VEGF	48,52	Metallothionein-III	0,19	VEGF	Metallothionein-III	22339(Tax:10090)	17751(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells .
25575606	0	VEGF	89,93	MiR-214	0,7	VEGF	MiR-214	7422	406996	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-214 regulates the pathogenesis of patients with coronary_artery_disease by targeting VEGF .
24815691	0	VEGF	18,22	MiR-718	0,7	VEGF	MiR-718	7422	100313781	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	MiR-718 represses VEGF and inhibits ovarian_cancer cell progression .
18392135	0	VEGF	38,42	Midkine	18,25	VEGF	Midkine	7422	4192	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	The growth factor Midkine antagonizes VEGF signaling in vitro and in vivo .
18278068	0	VEGF	44,48	N-myc	0,5	VEGF	N-myc	7422	4613	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma .
19661463	0	VEGF	0,4	NFATc1	29,35	VEGF	NFATc1	22339(Tax:10090)	18018(Tax:10090)	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	VEGF and RANKL regulation of NFATc1 in heart valve development .
26285747	0	VEGF	80,84	NFkB	66,70	VEGF	NFkB	83785(Tax:10116)	81736(Tax:10116)	Gene	Gene	Promoter|compound|START_ENTITY END_ENTITY|nmod|Promoter	Chromatin Immunoprecipitation Assay : Examining the Interaction of NFkB with the VEGF Promoter .
21653826	0	VEGF	0,4	NRP1	112,116	VEGF	NRP1	7422	8829	Gene	Gene	binding|compound|START_ENTITY essential|nsubj|binding essential|advcl|VEGF VEGF|dobj|stimulation stimulation|nmod|migration migration|appos|formation formation|nmod|END_ENTITY	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
21653826	0	VEGF	0,4	NRP1	16,20	VEGF	NRP1	7422	8829	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
21653826	0	VEGF	38,42	NRP1	112,116	VEGF	NRP1	7422	8829	Gene	Gene	START_ENTITY|dobj|stimulation stimulation|nmod|migration migration|appos|formation formation|nmod|END_ENTITY	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
21653826	0	VEGF	38,42	NRP1	16,20	VEGF	NRP1	7422	8829	Gene	Gene	essential|advcl|START_ENTITY essential|nsubj|binding binding|nmod|END_ENTITY	VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration , complex formation between NRP1 and VEGFR2 , and signaling via FAK Tyr407 phosphorylation .
12613545	0	VEGF	84,88	Neuropilin-1	19,31	VEGF	Neuropilin-1	7422	8829	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF .
18769069	0	VEGF	39,43	Neuropilin-1	0,12	VEGF	Neuropilin-1	397157(Tax:9823)	100286859(Tax:9823)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Neuropilin-1 is essential for enhanced VEGF -LRB- 165 -RRB- - mediated vasodilatation in collateral-dependent coronary arterioles of exercise-trained pigs .
22033923	0	VEGF	54,58	Nrf2	109,113	VEGF	Nrf2	7422	4780	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Interplay between vascular_endothelial_growth_factor -LRB- VEGF -RRB- and nuclear_factor_erythroid_2-related_factor-2 -LRB- Nrf2 -RRB- : implications for preeclampsia .
20715116	0	VEGF	0,4	Nurr1	68,73	VEGF	Nurr1	7422	4929	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression : role in VEGF-induced angiogenesis .
22110141	0	VEGF	66,70	Osterix	116,123	VEGF	Osterix	22339(Tax:10090)	170574(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- by osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- in osteoblasts .
16416012	0	VEGF	31,35	P53	0,3	VEGF	P53	7422	7157	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	P53 correlates positively with VEGF in preoperative sera of colorectal_cancer patients .
24507679	0	VEGF	10,14	P53_and_telomerase	16,34	VEGF	P53 and telomerase	7422	7157	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of VEGF , P53_and_telomerase on angiogenesis of gastric_carcinoma tissue .
17201255	0	VEGF	27,31	PC-3	57,61	VEGF	PC-3	7422	57332	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- RNA interference inhibits VEGF expression and growth of PC-3 in prostate_carcinoma -RSB- .
15273770	0	VEGF	67,71	PCNA	43,47	VEGF	PCNA	7422	5111	Gene	Gene	Bcl-2|dep|START_ENTITY Bcl-2|dep|END_ENTITY	Expression of biomolecular markers -LRB- Ki-67 , PCNA , Bcl-2 , BAX , BclX , VEGF -RRB- in breast_tumors .
10691304	0	VEGF	50,54	PDGFR-beta	106,116	VEGF	PDGFR-beta	7422	5159	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and platelet-derived_growth_factor_receptor-beta -LRB- PDGFR-beta -RRB- in human gliomas .
19129951	0	VEGF	15,19	PEA3	0,4	VEGF	PEA3	7422	2118	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	PEA3 activates VEGF transcription in T47D and SKBR3 breast_cancer cells .
12957143	0	VEGF	95,99	PEDF	49,53	VEGF	PEDF	7422	57104	Gene	Gene	pigment_epithelium-derived_factor|appos|START_ENTITY pigment_epithelium-derived_factor|appos|END_ENTITY	Expression of pigment_epithelium-derived_factor -LRB- PEDF -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- in sickle cell retina and choroid .
15985268	0	VEGF	113,117	PEDF	35,39	VEGF	PEDF	7422	57104	Gene	Gene	expression|appos|START_ENTITY apoptosis|nmod|expression Pigment_epithelium-derived_factor|dep|apoptosis Pigment_epithelium-derived_factor|appos|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16624340	0	VEGF	109,113	PEDF	35,39	VEGF	PEDF	7422	5176	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY expression|compound|vascular_endothelial_growth_factor inhibits|dobj|expression inhibits|nsubj|factor factor|appos|END_ENTITY	Pigment-epithelium-derived factor -LRB- PEDF -RRB- inhibits angiotensin-II-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MOLT-3 T cells through anti-oxidative properties .
16735992	0	VEGF	77,81	PEDF	121,125	VEGF	PEDF	22339(Tax:10090)	20317(Tax:10090)	Gene	Gene	migration|appos|START_ENTITY migration|appos|END_ENTITY	Angiostatin decreases cell migration and vascular_endothelium_growth_factor -LRB- VEGF -RRB- to pigment_epithelium_derived_factor -LRB- PEDF -RRB- RNA ratio in vitro and in a murine ocular_melanoma model .
19696171	0	VEGF	34,38	PEDF	85,89	VEGF	PEDF	281572(Tax:9913)	100337325	Gene	Gene	Inhibition|nmod|START_ENTITY upregulation|nsubj|Inhibition upregulation|nmod|END_ENTITY	Inhibition of JAK2/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in vitro .
20049507	0	VEGF	63,67	PEDF	108,112	VEGF	PEDF	7422	5176	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Intra-ocular expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and pigment_epithelial-derived_factor -LRB- PEDF -RRB- in a case of Eales ' _ disease by immunohistochemical analysis : a case report .
22057317	0	VEGF	27,31	PEDF	0,4	VEGF	PEDF	83785(Tax:10116)	287526(Tax:10116)	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	PEDF effectively decreases VEGF to PEDF messenger RNA ratio of the inner edge of rat hepatocellular carcinoma induced by diethyl_nitrosamine - an `` in vivo '' study .
22057317	0	VEGF	27,31	PEDF	35,39	VEGF	PEDF	83785(Tax:10116)	287526(Tax:10116)	Gene	Gene	decreases|dobj|START_ENTITY decreases|xcomp|END_ENTITY	PEDF effectively decreases VEGF to PEDF messenger RNA ratio of the inner edge of rat hepatocellular carcinoma induced by diethyl_nitrosamine - an `` in vivo '' study .
26308290	0	VEGF	42,46	PEDF	34,38	VEGF	PEDF	22339(Tax:10090)	20317(Tax:10090)	Gene	Gene	Inversely|compound|START_ENTITY END_ENTITY|nmod|Inversely	GnRH Agonist Triggering Modulates PEDF to VEGF Ratio Inversely to hCG in Granulosa Cells .
18288196	0	VEGF	30,34	PGC-1alpha	87,97	VEGF	PGC-1alpha	22339(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha .
23429328	0	VEGF	14,18	PI3K	25,29	VEGF	PI3K	7422	5293	Gene	Gene	Markers|nummod|START_ENTITY Markers|nummod|END_ENTITY	Markers CD40 , VEGF , AKT , PI3K , and S100 correlate with tumor stage in gastric_cancer .
18323518	0	VEGF	27,31	PKC-alpha	45,54	VEGF	PKC-alpha	281572(Tax:9913)	282001(Tax:9913)	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells .
11779150	0	VEGF	21,25	PKC_and_ERK	41,52	VEGF	PKC and ERK	22339(Tax:10090)	26413(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	High glucose induced VEGF expression via PKC_and_ERK in glomerular podocytes .
15670761	0	VEGF	70,74	PPAR-gamma	0,10	VEGF	PPAR-gamma	22339(Tax:10090)	19016(Tax:10090)	Gene	Gene	release|amod|START_ENTITY up-regulate|dobj|release up-regulate|nsubj|ligands ligands|amod|END_ENTITY	PPAR-gamma ligands up-regulate basic_fibroblast_growth_factor-induced VEGF release through amplifying SAPK/JNK activation in osteoblasts .
16904074	0	VEGF	42,46	PPAR-gamma	112,122	VEGF	PPAR-gamma	281572(Tax:9913)	281993(Tax:9913)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma .
17320065	0	VEGF	45,49	PPAR-gamma	0,10	VEGF	PPAR-gamma	83785(Tax:10116)	25664(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|agonists agonists|amod|END_ENTITY	PPAR-gamma agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts .
16400517	0	VEGF	21,25	PPAR_gamma	0,10	VEGF	PPAR gamma	7422	5468	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	PPAR_gamma represses VEGF expression in human endometrial cells : implications for uterine angiogenesis .
26814431	0	VEGF	93,97	PPARy	21,26	VEGF	PPARy	7422	5468	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Fatty_acid activated PPARy promotes tumorigenicity of prostate_cancer cells by up regulating VEGF via PPAR responsive elements of the promoter .
16969073	0	VEGF	32,36	PV-1	0,4	VEGF	PV-1	22339(Tax:10090)	84094(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	PV-1 is negatively regulated by VEGF in the lung of caveolin-1 , but not caveolin-2 , null mice .
16901919	0	VEGF	84,88	Pigment_epithelium-derived_factor	0,33	VEGF	Pigment epithelium-derived factor	83785(Tax:10116)	287526(Tax:10116)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Pigment_epithelium-derived_factor downregulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and inhibits VEGF-VEGF receptor 2 binding in diabetic_retinopathy .
21617872	0	VEGF	110,114	Pigment_epithelium-derived_factor	0,33	VEGF	Pigment epithelium-derived factor	7422	57104	Gene	Gene	down-regulation|nmod|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	Pigment_epithelium-derived_factor inhibits angiogenesis and growth of gastric_carcinoma by down-regulation of VEGF .
10606981	0	VEGF	74,78	PlGF	24,28	VEGF	PlGF	7422	5228	Gene	Gene	secretion|appos|START_ENTITY induces|dobj|secretion induces|nsubj|Placenta_growth_factor Placenta_growth_factor|appos|END_ENTITY	Placenta_growth_factor -LRB- PlGF -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid .
11006323	0	VEGF	50,54	PlGF	85,89	VEGF	PlGF	574209(Tax:9544)	701219(Tax:9544)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and placental_growth_factor -LRB- PlGF -RRB- in conceptus and endometrium during implantation in the rhesus_monkey .
12796773	0	VEGF	69,73	PlGF	8,12	VEGF	PlGF	22339(Tax:10090)	18654(Tax:10090)	Gene	Gene	Flt1|compound|START_ENTITY talk|nmod|Flt1 Role|nmod|talk Role|nmod|END_ENTITY	Role of PlGF in the intra - and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 .
18258238	0	VEGF	0,4	PlGF	45,49	VEGF	PlGF	22339(Tax:10090)	18654(Tax:10090)	Gene	Gene	function|nsubj|START_ENTITY function|nmod|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis .
7478581	0	VEGF	52,56	PlGF	104,108	VEGF	PlGF	7422	5228	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY Upregulation|nmod|vascular_endothelial_growth_factor Upregulation|appos|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and downregulation of placenta_growth_factor -LRB- PlGF -RRB- associated with malignancy in human thyroid_tumors and cell lines .
9886308	0	VEGF	44,48	PlGF	86,90	VEGF	PlGF	7422	5228	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and placenta-derived growth factor -LRB- PlGF -RRB- in regulating human haemopoietic cell growth .
14980508	0	VEGF	62,66	Plasminogen_activator_inhibitor-1	0,33	VEGF	Plasminogen activator inhibitor-1	7422	5054	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Plasminogen_activator_inhibitor-1 increases the expression of VEGF in human glioma cells .
17149374	0	VEGF	45,49	RAGE	12,16	VEGF	RAGE	7422	101669765	Gene	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Mesothelial RAGE activation by AGEs enhances VEGF release and potentiates capillary tube formation .
21229300	0	VEGF	29,33	RPE65	14,19	VEGF	RPE65	7422	6121	Gene	Gene	CD68|appos|START_ENTITY CD68|compound|END_ENTITY	Evaluation of RPE65 , CRALBP , VEGF , CD68 , and tyrosinase gene expression in human retinal pigment epithelial cells cultured on amniotic membrane .
19250552	0	VEGF	63,67	RRM2	138,142	VEGF	RRM2	7422	6241	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo : implication of RRM2 in angiogenesis .
19250552	0	VEGF	63,67	RRM2	18,22	VEGF	RRM2	7422	6241	Gene	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo : implication of RRM2 in angiogenesis .
16440308	0	VEGF	36,40	Rac1	77,81	VEGF	Rac1	22339(Tax:10090)	19353(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	c-Jun kinase mediates expression of VEGF induced at transcriptional level by Rac1 and Cdc42Hs but not by RhoA .
19404567	0	VEGF	14,18	Rac1	90,94	VEGF	Rac1	7422	5879	Gene	Gene	induces|nsubj|START_ENTITY increased|ccomp|induces increased|dep|pathway pathway|nmod|activation activation|amod|END_ENTITY	How increased VEGF induces glomerular_hyperpermeability : a potential signaling pathway of Rac1 activation .
21030561	0	VEGF	32,36	Rac1	7,11	VEGF	Rac1	7422	5879	Gene	Gene	architecture|compound|START_ENTITY improves|dobj|architecture improves|nsubj|END_ENTITY	Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak : mechanistic similarities with angiopoietin-1 .
25253431	0	VEGF	63,67	RhoGDI2	0,7	VEGF	RhoGDI2	7422	397	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach_cancer .
20498081	0	VEGF	39,43	Robo4	9,14	VEGF	Robo4	7422	54538	Gene	Gene	restricts|dobj|START_ENTITY restricts|nsubj|END_ENTITY	Vascular Robo4 restricts proangiogenic VEGF signaling in breast .
25318158	0	VEGF	13,17	S-100B	38,44	VEGF	S-100B	7422	6285	Gene	Gene	role|nmod|START_ENTITY -LSB-|dobj|role -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The role of VEGF , HSP-70 and protein S-100B in the potentiation effect of the neuroprotective effect of hypercapnic hypoxia -RSB- .
26396267	0	VEGF	52,56	SOCS3	0,5	VEGF	SOCS3	22339(Tax:10090)	12702(Tax:10090)	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth .
11554745	0	VEGF	22,26	SPARC	13,18	VEGF	SPARC	7422	6678	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of SPARC by VEGF in human vascular endothelial cells .
18408167	0	VEGF	64,68	STAT-3	36,42	VEGF	STAT-3	7422	6774	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis .
12824281	0	VEGF	0,4	STAT3	30,35	VEGF	STAT3	7422	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	VEGF differentially activates STAT3 in microvascular endothelial cells .
15688401	0	VEGF	130,134	STAT3	206,211	VEGF	STAT3	22339(Tax:10090)	20848(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nmod|cells cells|nmod|interaction interaction|nmod|END_ENTITY	Interleukin-6 induces transcriptional activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1 .
15919761	0	VEGF	49,53	STAT3	0,5	VEGF	STAT3	7422	6774	Gene	Gene	expression|amod|START_ENTITY modulator|nmod|expression modulator|nsubj|END_ENTITY	STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal_carcinoma cells .
16257644	0	VEGF	24,28	STAT3	74,79	VEGF	STAT3	7422	6774	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|cells cells|nmod|END_ENTITY	Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3 .
17009627	0	VEGF	0,4	STAT3	32,37	VEGF	STAT3	7422	6774	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian_carcinoma cells in vitro .
17509611	0	VEGF	49,53	STAT3	0,5	VEGF	STAT3	22339(Tax:10090)	20848(Tax:10090)	Gene	Gene	production|compound|START_ENTITY stem|dobj|production mediates|ccomp|stem mediates|nsubj|END_ENTITY	STAT3 mediates bone marrow mesenchymal stem cell VEGF production .
18981713	0	VEGF	47,51	STAT3	10,15	VEGF	STAT3	22339(Tax:10090)	20848(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediator|nmod|activation mediator|nsubj|END_ENTITY	Activated STAT3 is a mediator and biomarker of VEGF endothelial activation .
20204302	0	VEGF	33,37	STAT3	68,73	VEGF	STAT3	7422	6774	Gene	Gene	production|amod|START_ENTITY production|nmod|suppression suppression|nmod|END_ENTITY	Dexamethasone treatment inhibits VEGF production via suppression of STAT3 in a head_and_neck_cancer cell line .
23104276	0	VEGF	76,80	STAT3	44,49	VEGF	STAT3	7422	6774	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression .
22476930	0	VEGF	30,34	Semaphorin_4D	0,13	VEGF	Semaphorin 4D	7422	10507	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Semaphorin_4D cooperates with VEGF to promote angiogenesis and tumor progression .
15381031	0	VEGF	50,54	Somatostatin	0,12	VEGF	Somatostatin	7422	6750	Gene	Gene	induction|nmod|START_ENTITY mediated|dobj|induction mediated|nsubj|IGF-1 IGF-1|compound|END_ENTITY	Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal_pigment_epithelial cells .
11960372	0	VEGF	41,45	Stat3	13,18	VEGF	Stat3	7422	6774	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis .
21633597	0	VEGF	40,44	Stat3	76,81	VEGF	Stat3	7422	6774	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|IL-6 IL-6|nmod|END_ENTITY	-LRB- - -RRB- - Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric_cancer .
25151964	0	VEGF	0,4	Stat3	57,62	VEGF	Stat3	7422	6774	Gene	Gene	drives|nsubj|START_ENTITY drives|nmod|END_ENTITY	VEGF drives cancer-initiating stem cells through VEGFR-2 / Stat3 signaling to upregulate Myc and Sox2 .
26566627	0	VEGF	81,85	Stat3	42,47	VEGF	Stat3	7422	6774	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	IL-17 promotes tumor angiogenesis through Stat3 pathway mediated upregulation of VEGF in gastric_cancer .
9891517	0	VEGF	68,72	TEL	23,26	VEGF	TEL	7422	2120	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The ETS-related factor TEL is regulated by angiogenic growth factor VEGF in HUVE-cells .
21409414	0	VEGF	209,213	TGF-b	163,168	VEGF	TGF-b	7422	7040	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Advanced glycation end-products induce basement membrane hypertrophy in endoneurial microvessels and disrupt the blood-nerve barrier by stimulating the release of TGF-b and vascular_endothelial_growth_factor -LRB- VEGF -RRB- by pericytes .
21057546	0	VEGF	40,44	TGF-b1	58,64	VEGF	TGF-b1	7422	7040	Gene	Gene	isoforms|nmod|START_ENTITY functions|nmod|isoforms induction|nsubj|functions induction|nmod|END_ENTITY	Opposite functions of HIF-a isoforms in VEGF induction by TGF-b1 under non-hypoxic conditions .
22522454	0	VEGF	54,58	TGF-b1	0,6	VEGF	TGF-b1	7422	7040	Gene	Gene	activation|compound|START_ENTITY shifting|dobj|activation induces|advcl|shifting induces|nsubj|END_ENTITY	TGF-b1 induces endothelial cell apoptosis by shifting VEGF activation of p38 -LRB- MAPK -RRB- from the prosurvival p38b to proapoptotic p38a .
23684430	0	VEGF	0,4	TGF-b1	13,19	VEGF	TGF-b1	100008899(Tax:9986)	100008645(Tax:9986)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	VEGF induces TGF-b1 expression and myofibroblast transformation after glaucoma surgery .
26783748	0	VEGF	116,120	TGF-b2	109,115	VEGF	TGF-b2	83785(Tax:10116)	81809(Tax:10116)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	All-Trans_Retinoic_Acid Attenuates Hypoxia-Induced_Injury in NRK52E Cells via Inhibiting NF-x03BA ; B/VEGF and TGF-b2 / VEGF Pathway .
15629128	0	VEGF	38,42	TGF-beta1	15,24	VEGF	TGF-beta1	7422	7040	Gene	Gene	production|amod|START_ENTITY induction|nmod|production induction|compound|END_ENTITY	Smad3 mediates TGF-beta1 induction of VEGF production in lung fibroblasts .
15640959	0	VEGF	115,119	TGF-beta1	150,159	VEGF	TGF-beta1	7422	7040	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY alterations|amod|vascular_endothelial_growth_factor alterations|acl|transforming transforming|dobj|factor factor|appos|END_ENTITY	Early nuclear alterations and immunohistochemical expression of Ki-67 , Erb-B2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , transforming growth factor -LRB- TGF-beta1 -RRB- and integrine-linked kinase -LRB- ILK -RRB- two days after tamoxifen in breast_carcinoma .
15821013	0	VEGF	25,29	TGF-beta1	87,96	VEGF	TGF-beta1	443103(Tax:9940)	443417(Tax:9940)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|species species|amod|END_ENTITY	Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species : a requirement for NAD -LRB- P -RRB- H oxidase .
17088559	0	VEGF	0,4	TGF-beta1	49,58	VEGF	TGF-beta1	7422	7040	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|concert concert|nmod|END_ENTITY	VEGF , a prosurvival factor , acts in concert with TGF-beta1 to induce endothelial cell apoptosis .
18057050	0	VEGF	14,18	TGF-beta1	26,35	VEGF	TGF-beta1	22339(Tax:10090)	21803(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY blocks|nsubj|Inhibition blocks|dobj|production production|compound|END_ENTITY	Inhibition of VEGF blocks TGF-beta1 production through a PI3K/Akt signalling pathway .
19180561	0	VEGF	111,115	TGF-beta1	35,44	VEGF	TGF-beta1	7422	7040	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY induces|nmod|vascular_endothelial_growth_factor induces|nsubj|Transforming_growth_factor-beta_1 Transforming_growth_factor-beta_1|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- induces angiogenesis through vascular_endothelial_growth_factor -LRB- VEGF -RRB- - mediated apoptosis .
24941819	0	VEGF	54,58	TGF-beta1	27,36	VEGF	TGF-beta1	7422	7040	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	-LSB- Down-regulation effect of TGF-beta1 on expression of VEGF in bladder_cancer cell line -RSB- .
17331500	0	VEGF	14,18	TGF-beta2	60,69	VEGF	TGF-beta2	7422	7042	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of VEGF mRNA expression and protein secretion by TGF-beta2 in human retinal pigment epithelial cells .
24347177	0	VEGF	51,55	TIMP1	57,62	VEGF	TIMP1	7422	7076	Gene	Gene	IL-6|compound|START_ENTITY IL-6|appos|END_ENTITY	The activation of TLR7 regulates the expression of VEGF , TIMP1 , MMP2 , IL-6 , and IL-15 in Hela cells .
27043859	0	VEGF	44,48	TIPE2	18,23	VEGF	TIPE2	7422	79626	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Anti-inflammatory TIPE2 inhibits angiogenic VEGF in retinal_pigment_epithelium .
23185615	0	VEGF	58,62	TLR4	67,71	VEGF	TLR4	22339(Tax:10090)	21898(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nummod|END_ENTITY	Peroxiredoxin_1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1a .
23328798	0	VEGF	91,95	TNF	46,49	VEGF	TNF	7422	7124	Gene	Gene	tumor_necrosis_factor|appos|START_ENTITY tumor_necrosis_factor|appos|END_ENTITY	Combined inhibition of tumor_necrosis_factor -LRB- TNF -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- for the treatment of macular_edema of various etiologies : a short-term pilot study .
10403932	0	VEGF	133,137	TNF-alpha	196,205	VEGF	TNF-alpha	7422	7124	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|dep|factor-alpha factor-alpha|appos|END_ENTITY	Peripheral blood mononuclear cells from patients with rheumatoid_arthritis spontaneously secrete vascular_endothelial_growth_factor -LRB- VEGF -RRB- : specific up-regulation by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- in synovial fluid .
11860736	0	VEGF	0,4	TNF-alpha	51,60	VEGF	TNF-alpha	281572(Tax:9913)	280943(Tax:9913)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|apoptosis apoptosis|amod|END_ENTITY	VEGF protects bovine aortic endothelial cells from TNF-alpha - and H2O2-induced apoptosis via co-modulatory effects on p38-and p42/p44-CCDPK signaling .
12551841	0	VEGF	11,15	TNF-alpha	26,35	VEGF	TNF-alpha	7422	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|pathway pathway|amod|END_ENTITY	UV induces VEGF through a TNF-alpha independent pathway .
16040218	0	VEGF	49,53	TNF-alpha	0,9	VEGF	TNF-alpha	7422	7124	Gene	Gene	production|amod|START_ENTITY increase|dobj|production increase|nsubj|END_ENTITY	TNF-alpha and endotoxin increase hypoxia-induced VEGF production by cultured human nasal fibroblasts in synergistic fashion .
16438902	0	VEGF	55,59	TNF-alpha	11,20	VEGF	TNF-alpha	7422	7124	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells .
17096908	0	VEGF	58,62	TNF-alpha	27,36	VEGF	TNF-alpha	7422	7124	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of triptolide and TNF-alpha on the expression of VEGF in Raji cells and on angiogenesis in ECV304 cells -RSB- .
17725274	0	VEGF	79,83	TNF-alpha	109,118	VEGF	TNF-alpha	7422	7124	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|tumor_necrosis_factor tumor_necrosis_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
15041794	0	VEGF	51,55	TP	86,88	VEGF	TP	7422	1890	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	combination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and thymidine_phosphorylase -LRB- TP -RRB- to improve angiogenic gene therapy .
12957289	0	VEGF	15,19	TSC2	0,4	VEGF	TSC2	7422	7249	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TSC2 regulates VEGF through mTOR-dependent and - independent pathways .
11686329	0	VEGF	55,59	Thrombin	0,8	VEGF	Thrombin	7422	2147	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces increased expression and secretion of VEGF from human FS4 fibroblasts , DU145 prostate cells and CHRF megakaryocytes .
25310246	0	VEGF	33,37	Thrombin	21,29	VEGF	Thrombin	7422	2147	Gene	Gene	Secretion|compound|START_ENTITY Effects|nmod|Secretion Effects|nmod|END_ENTITY	Different Effects of Thrombin on VEGF Secretion , Proliferation , and Permeability in Polarized and Non-polarized Retinal Pigment Epithelial Cells .
22235284	0	VEGF	99,103	Tie1	56,60	VEGF	Tie1	7422	7075	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFa and regulates angiopoietin signalling .
17901375	0	VEGF	0,4	Tie2	13,17	VEGF	Tie2	7422	7010	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling .
17901375	0	VEGF	0,4	Tie2	93,97	VEGF	Tie2	7422	7010	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|Tie2 Tie2|acl|shedding shedding|nmod|END_ENTITY	VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling .
21525162	0	VEGF	124,128	Tie2	30,34	VEGF	Tie2	7422	7010	Gene	Gene	result|appos|START_ENTITY Decreased|nsubj|result Decreased|xcomp|circulating circulating|dobj|levels levels|amod|END_ENTITY	Decreased circulating soluble Tie2 levels in preeclampsia may result from inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- signaling .
23149917	0	VEGF	91,95	Tie2	30,34	VEGF	Tie2	7422	7010	Gene	Gene	inhibition|compound|START_ENTITY effects|nmod|inhibition limits|dobj|effects agonist|advcl|limits agonist|nsubj|functions functions|nmod|END_ENTITY	Angiopoietin-2 functions as a Tie2 agonist in tumor models , where it limits the effects of VEGF inhibition .
24782650	0	VEGF	65,69	Toll-like_receptor_8	18,38	VEGF	Toll-like receptor 8	7422	51311	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of Toll-like_receptor_8 and its relationship with VEGF and Bcl-2 in cervical_cancer .
19697322	0	VEGF	40,44	Tristetraprolin	0,15	VEGF	Tristetraprolin	7422	7538	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon_cancer .
23597635	0	VEGF	52,56	Tropoelastin	0,12	VEGF	Tropoelastin	7422	2006	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Tropoelastin modulates TGF-b1-induced expression of VEGF and CTGF in airway smooth muscle cells .
12652295	0	VEGF	113,117	VEGF	129,133	VEGF	VEGF	7422	7422	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	A novel function for tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP3 -RRB- : inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2 .
12652295	0	VEGF	129,133	VEGF	113,117	VEGF	VEGF	7422	7422	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	A novel function for tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP3 -RRB- : inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2 .
16269210	0	VEGF	30,34	VEGF	38,42	VEGF	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenitors .
16269210	0	VEGF	38,42	VEGF	30,34	VEGF	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenitors .
16350854	0	VEGF	66,70	VEGF	82,86	VEGF	VEGF	7422	7422	Gene	Gene	binding|compound|START_ENTITY binding|nmod|receptor receptor|compound|END_ENTITY	Sanguiin_H-6 blocks endothelial cell growth through inhibition of VEGF binding to VEGF receptor .
16350854	0	VEGF	82,86	VEGF	66,70	VEGF	VEGF	7422	7422	Gene	Gene	receptor|compound|START_ENTITY binding|nmod|receptor binding|compound|END_ENTITY	Sanguiin_H-6 blocks endothelial cell growth through inhibition of VEGF binding to VEGF receptor .
17393106	0	VEGF	27,31	VEGF	35,39	VEGF	VEGF	7422	7422	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of shRNA targeting VEGF on VEGF mRNA expression in gastric_cancer cells .
17393106	0	VEGF	35,39	VEGF	27,31	VEGF	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effects of shRNA targeting VEGF on VEGF mRNA expression in gastric_cancer cells .
17560831	0	VEGF	22,26	VEGF	48,52	VEGF	VEGF	7422	7422	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Angiogenesis markers -LRB- VEGF , soluble receptor of VEGF and angiopoietin-1 -RRB- in very_early_arthritis and their association with inflammation and joint destruction .
17560831	0	VEGF	48,52	VEGF	22,26	VEGF	VEGF	7422	7422	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Angiogenesis markers -LRB- VEGF , soluble receptor of VEGF and angiopoietin-1 -RRB- in very_early_arthritis and their association with inflammation and joint destruction .
18987662	0	VEGF	12,16	VEGF	47,51	VEGF	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of VEGF and a functional link between VEGF and p27Kip1 in acute_myeloid_leukemia .
18987662	0	VEGF	47,51	VEGF	12,16	VEGF	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of VEGF and a functional link between VEGF and p27Kip1 in acute_myeloid_leukemia .
20035107	0	VEGF	104,108	VEGF	14,18	VEGF	VEGF	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle : effects of VEGF on prostaglandin production in endometrial cells .
20035107	0	VEGF	14,18	VEGF	104,108	VEGF	VEGF	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|effects effects|nmod|END_ENTITY	Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle : effects of VEGF on prostaglandin production in endometrial cells .
20589895	0	VEGF	28,32	VEGF	45,49	VEGF	VEGF	7422	7422	Gene	Gene	correlation|nmod|START_ENTITY END_ENTITY|nsubj|correlation	Inverse correlation between VEGF and soluble VEGF receptor 2 in POEMS with AIDP responsive to intravenous immunoglobulin .
20589895	0	VEGF	45,49	VEGF	28,32	VEGF	VEGF	7422	7422	Gene	Gene	START_ENTITY|nsubj|correlation correlation|nmod|END_ENTITY	Inverse correlation between VEGF and soluble VEGF receptor 2 in POEMS with AIDP responsive to intravenous immunoglobulin .
16491267	0	VEGF	61,65	VEGF-C	68,74	VEGF	VEGF-C	7422	7424	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Increased expressions of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , VEGF-C and VEGF_receptor-3 in prostate_cancer tissue are associated with tumor progression .
15492987	0	VEGF	50,54	VEGF-R1	75,82	VEGF	VEGF-R1	7422	2321	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|dep|-RSB- -RSB-|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
12509223	0	VEGF	82,86	VEGFR	54,59	VEGF	VEGFR	7422	3791	Gene	Gene	stimulation|compound|START_ENTITY associated|nmod|stimulation associated|nmod|END_ENTITY	Src kinase becomes preferentially associated with the VEGFR , KDR/Flk -1 , following VEGF stimulation of vascular endothelial cells .
14714966	0	VEGF	110,114	VEGFR	135,140	VEGF	VEGFR	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Dermatomyositis with peripheral nervous system involvement : activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and VEGF_receptor -LRB- VEGFR -RRB- in vasculitic_lesions .
17098419	0	VEGF	69,73	VEGFR	124,129	VEGF	VEGFR	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	The clinical toxicity profile of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and vascular_endothelial_growth_factor receptor -LRB- VEGFR -RRB- targeting angiogenesis inhibitors ; a review .
25676691	0	VEGF	37,41	VEGFR	0,5	VEGF	VEGFR	7422	3791	Gene	Gene	glioblastoma|amod|START_ENTITY inhibitors|nmod|glioblastoma inhibitors|nsubj|END_ENTITY	VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFbR signaling-dependent manner .
12850696	0	VEGF	66,70	VEGFR-1	52,59	VEGF	VEGFR-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY END_ENTITY|nmod|stimulation	ERK/MAPK-dependent PI3K/Akt phosphorylation through VEGFR-1 after VEGF stimulation in activated hepatic stellate cells .
11967019	0	VEGF	76,80	VEGFR-2	49,56	VEGF	VEGFR-2	7422	3791	Gene	Gene	expression|amod|START_ENTITY increasing|dobj|expression END_ENTITY|advcl|increasing	Renal_ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression .
12094254	0	VEGF	54,58	VEGFR-2	91,98	VEGF	VEGFR-2	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Overexpression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its cellular receptor KDR -LRB- VEGFR-2 -RRB- in the bone marrow of patients with acute_myeloid_leukemia .
12205052	0	VEGF	99,103	VEGFR-2	53,60	VEGF	VEGFR-2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY inducing|dobj|synthesis promotes|advcl|inducing promotes|dobj|angiogenesis angiogenesis|nmod|vivo vivo|nmod|pathway pathway|compound|END_ENTITY	Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion .
12551914	0	VEGF	83,87	VEGFR-2	151,158	VEGF	VEGFR-2	7422	3791	Gene	Gene	set|appos|START_ENTITY essential|nsubj|set essential|nmod|activation activation|nmod|signaling signaling|compound|END_ENTITY	A set of loop-1 and -3 structures in the novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- family member , VEGF-ENZ-7 , is essential for the activation of VEGFR-2 signaling .
14626450	0	VEGF	164,168	VEGFR-2	110,117	VEGF	VEGFR-2	7422	3791	Gene	Gene	responses|nmod|START_ENTITY identifies|nmod|responses identifies|dobj|role role|nmod|END_ENTITY	Selective inhibition of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF .
14626450	0	VEGF	164,168	VEGFR-2	71,78	VEGF	VEGFR-2	7422	3791	Gene	Gene	responses|nmod|START_ENTITY identifies|nmod|responses identifies|nsubj|inhibition inhibition|nmod|vascular_endothelial_growth_factor_receptor-2 vascular_endothelial_growth_factor_receptor-2|appos|END_ENTITY	Selective inhibition of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF .
15111299	0	VEGF	40,44	VEGFR-2	88,95	VEGF	VEGFR-2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	Flt-1|appos|START_ENTITY modulates|nsubj|Flt-1 modulates|dobj|Flk-1 Flk-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
16914140	0	VEGF	186,190	VEGFR-2	110,117	VEGF	VEGFR-2	7422	3791	Gene	Gene	mechanism|nmod|START_ENTITY formation|dep|mechanism formation|nmod|II II|appos|END_ENTITY	Complex formation between tissue_transglutaminase II -LRB- tTG -RRB- and vascular_endothelial_growth_factor_receptor_2 -LRB- VEGFR-2 -RRB- : proposed mechanism for modulation of endothelial cell response to VEGF .
16930552	0	VEGF	53,57	VEGFR-2	14,21	VEGF	VEGFR-2	7422	3791	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of VEGFR-2 on HaCaT cells is regulated by VEGF and plays an active role in mediating VEGF induced effects .
16966330	0	VEGF	174,178	VEGFR-2	34,41	VEGF	VEGFR-2	7422	3791	Gene	Gene	leading|nmod|START_ENTITY Fyn|acl|leading recruitment|nmod|Fyn triggers|dobj|recruitment triggers|nsubj|Phosphorylation Phosphorylation|nmod|Tyr1214 Tyr1214|nmod|END_ENTITY	Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF .
17024605	0	VEGF	66,70	VEGFR-2	88,95	VEGF	VEGFR-2	7422	3791	Gene	Gene	angiogenesis|nmod|START_ENTITY angiogenesis|amod|END_ENTITY	Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1 , not VEGFR-2 .
17512973	0	VEGF	0,4	VEGFR-2	101,108	VEGF	VEGFR-2	7422	3791	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|dep|involvement involvement|nmod|activator activator|compound|END_ENTITY	VEGF increases the fibrinolytic activity of endothelial cells within fibrin matrices : involvement of VEGFR-2 , tissue type plasminogen activator and matrix metalloproteinases .
19540581	0	VEGF	151,155	VEGFR-2	70,77	VEGF	VEGFR-2	7422	3791	Gene	Gene	immobilized|dobj|START_ENTITY immobilized|nsubj|phosphorylation phosphorylation|appos|END_ENTITY	The phosphorylation of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- by engineered surfaces with electrostatically or covalently immobilized VEGF .
20961309	0	VEGF	51,55	VEGFR-2	8,15	VEGF	VEGFR-2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY variant|nmod|receptors END_ENTITY|dep|variant	Soluble VEGFR-2 : an antilymphangiogenic variant of VEGF receptors .
21826315	0	VEGF	0,4	VEGFR-2	41,48	VEGF	VEGFR-2	7422	3791	Gene	Gene	internalization|compound|START_ENTITY required|nsubjpass|internalization required|nmod|phosphorylation phosphorylation|compound|END_ENTITY	VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF .
21826315	0	VEGF	114,118	VEGFR-2	41,48	VEGF	VEGFR-2	7422	3791	Gene	Gene	required|nmod|START_ENTITY required|nmod|phosphorylation phosphorylation|compound|END_ENTITY	VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF .
21849059	0	VEGF	16,20	VEGFR-2	117,124	VEGF	VEGFR-2	7422	3791	Gene	Gene	Cytotoxicity|nmod|START_ENTITY mediated|nsubjpass|Cytotoxicity mediated|nmod|END_ENTITY	Cytotoxicity of VEGF -LRB- 121 -RRB- / rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2 .
25151964	0	VEGF	0,4	VEGFR-2	49,56	VEGF	VEGFR-2	7422	3791	Gene	Gene	drives|nsubj|START_ENTITY drives|nmod|Stat3 Stat3|compound|END_ENTITY	VEGF drives cancer-initiating stem cells through VEGFR-2 / Stat3 signaling to upregulate Myc and Sox2 .
25546248	0	VEGF	121,125	VEGFR-2	21,28	VEGF	VEGFR-2	7422	3791	Gene	Gene	gallate|nmod|START_ENTITY tight|nmod|gallate activation|nmod|tight activation|compound|END_ENTITY	Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF : Relevance to angiogenesis .
25825981	0	VEGF	75,79	VEGFR-2	39,46	VEGF	VEGFR-2	7422	3791	Gene	Gene	mediating|nmod|START_ENTITY END_ENTITY|acl|mediating	EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF .
26154255	0	VEGF	87,91	VEGFR-2	93,100	VEGF	VEGFR-2	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	Vascular_Endothelial_Growth_Factor|appos|START_ENTITY Vascular_Endothelial_Growth_Factor|dep|Signaling Signaling|compound|END_ENTITY	Geraniol Suppresses Angiogenesis by Downregulating Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- / VEGFR-2 Signaling .
26777435	0	VEGF	0,4	VEGFR-2	48,55	VEGF	VEGFR-2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	VEGF released from a fibrin biomatrix increases VEGFR-2 expression and improves early outcome after ischaemia-reperfusion injury .
10744763	0	VEGF	36,40	VEGFR2	85,91	VEGF	VEGFR2	7422	3791	Gene	Gene	Vascular_endothelial_growth_factor|appos|START_ENTITY Vascular_endothelial_growth_factor|acl|driven driven|ccomp|mediated mediated|nmod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated_protein_kinase_2 -LRB- SAPK2/p38 -RRB- and geldanamycin-sensitive phosphorylation of focal_adhesion_kinase .
12406893	0	VEGF	135,139	VEGFR2	32,38	VEGF	VEGFR2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	threshold|nmod|START_ENTITY tuning|dobj|threshold reveals|advcl|tuning reveals|nsubj|culture culture|nmod|cells cells|nummod|END_ENTITY	A chemically defined culture of VEGFR2 + cells derived from embryonic stem cells reveals the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells .
12549858	0	VEGF	34,38	VEGFR2	50,56	VEGF	VEGFR2	7422	3791	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	A monoclonal antibody that blocks VEGF binding to VEGFR2 -LRB- KDR/Flk -1 -RRB- inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast_cancer model .
15328520	0	VEGF	86,90	VEGFR2	23,29	VEGF	VEGFR2	7422	3791	Gene	Gene	expression|nmod|START_ENTITY tyrosine|nmod|expression tyrosine|nsubj|efficacy efficacy|nmod|END_ENTITY	Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models .
17009627	0	VEGF	0,4	VEGFR2	54,60	VEGF	VEGFR2	7422	3791	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian_carcinoma cells in vitro .
23454747	0	VEGF	6,10	VEGFR2	11,17	VEGF	VEGFR2	7422	3791	Gene	Gene	START_ENTITY|parataxis|triggers triggers|nsubj|loop loop|nummod|END_ENTITY	Tumor VEGF : VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung_cancer .
23896411	0	VEGF	27,31	VEGFR2	74,80	VEGF	VEGFR2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY modulates|dobj|signaling modulates|advcl|recruiting recruiting|nmod|cells cells|nummod|END_ENTITY	Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells .
24986423	0	VEGF	0,4	VEGFR2	64,70	VEGF	VEGFR2	443103(Tax:9940)	443087(Tax:9940)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|permeability permeability|nmod|stimulation stimulation|compound|END_ENTITY	VEGF increases the permeability of sheep pleura ex vivo through VEGFR2 stimulation .
27105528	0	VEGF	47,51	VEGFR2	63,69	VEGF	VEGFR2	7422	3791	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2 .
18155761	0	VEGF	48,52	VEGF_receptor_2	57,72	VEGF	VEGF receptor 2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	The role of actively released fibrin-conjugated VEGF for VEGF_receptor_2 gene activation and the enhancement of angiogenesis .
22110141	0	VEGF	66,70	Vascular_Endothelial_Growth_Factor	30,64	VEGF	Vascular Endothelial Growth Factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- by osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- in osteoblasts .
23756839	0	VEGF	50,54	Vascular_Endothelial_Growth_Factor	14,48	VEGF	Vascular Endothelial Growth Factor	7422	7422	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- mRNA in healthy bone tissue around implants and in peri-implantitis .
24171833	0	VEGF	50,54	Vascular_Endothelial_Growth_Factor	14,48	VEGF	Vascular Endothelial Growth Factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- in Macrophages , Fibroblasts , and Endothelial Cells in Pterygium Treated with 5-Fluorouracil .
26083024	0	VEGF	91,95	Vascular_Endothelial_Growth_Factor	55,89	VEGF	Vascular Endothelial Growth Factor	7422	7422	Gene	Gene	Inhibitors|appos|START_ENTITY Inhibitors|compound|END_ENTITY	A Systematic Review and Meta-Analysis on the Safety of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- Inhibitors for the Treatment of Retinopathy_of_Prematurity .
10944602	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression is a prognostic factor for radiotherapy outcome in advanced carcinoma_of_the_cervix .
11398859	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the subacromial bursa is increased in patients with impingement_syndrome .
11491018	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression regulates angiogenesis accompanying tumor growth in a peritoneal disseminated tumor model .
11506249	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in peritoneal_dialysis effluent .
11545235	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in oral tissues : possible relevance to angiogenesis , tumour_progression_and_field_cancerisation .
12706123	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	signaling|appos|START_ENTITY signaling|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 signaling mediates VEGF-C -LRB- deltaNdeltaC -RRB- - and VEGF-A-induced angiogenesis in vitro .
12969663	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and the effect of exogenous VEGF on survival of a random flap in the rat .
12969663	0	VEGF	81,85	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and the effect of exogenous VEGF on survival of a random flap in the rat .
15233640	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor neuropilin-1 's distribution in astrocytic_tumors .
15601306	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels as a tool to discriminate between malignant and nonmalignant ascites .
17279364	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels of gingiva and gingival crevicular fluid in diabetic and systemically healthy periodontitis patients .
17348829	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- inhibition -- a critical review .
17486644	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor antibody bevacizumab -LRB- avastin -RRB- induces regression of renal_cell_carcinoma in an adolescent resulting in residual tumorectomy .
17897503	0	VEGF	47,51	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression -LRB- VEGF -RRB- in salivary glands of diabetic rats .
18721343	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- response to dental trauma : a preliminary study in rats .
19968501	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- serum levels are associated with survival in early stages of lung_cancer patients .
20417690	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- polymorphism is associated with treatment_resistant_depression .
21344505	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms and gastric_cancer risk in a Chinese Han population .
22139971	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	influence|dep|START_ENTITY influence|nsubj|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms may influence the efficacy of thalidomide in multiple_myeloma .
22209952	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- +405 _ C/G polymorphism is associated with essential hypertension in a population from Tehran of Iran .
23098265	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors : drugs and new inhibitors .
23618468	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in locally advanced prostate_cancer : secondary analysis of radiation therapy oncology group -LRB- RTOG -RRB- 8610 .
23725153	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms and breast_cancer risk in a Chinese population .
25106408	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms and breast_cancer risk in Punjabi population from North West India .
25230786	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- pathway and neuroendocrine_neoplasms -LRB- NENs -RRB- : prognostic and therapeutic considerations .
25344824	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in short , GH treated children : a distinct pattern of VEGF-C in Noonan_syndrome .
26113661	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- regulation by hypoxia inducible factor-1 alpha -LRB- HIF1A -RRB- starts and peaks during endometrial breakdown , not repair , in a mouse menstrual-like model .
26486233	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- -634 G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level .
8589021	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA expression in human tumor models of different histologies .
8671190	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	concentrations|appos|START_ENTITY concentrations|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- concentrations are elevated in peritoneal fluid of women with endometriosis .
9815864	0	VEGF	36,40	Vascular_endothelial_growth_factor	0,34	VEGF	Vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human coronary_atherosclerotic_lesions : possible pathophysiological significance of VEGF in progression of atherosclerosis .
9751730	0	VEGF	55,59	Vascular_endothelial_growth_factor_B	0,36	VEGF	Vascular endothelial growth factor B	7422	7423	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Vascular_endothelial_growth_factor_B -LRB- VEGF-B -RRB- binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells .
16998811	0	VEGF	43,47	WAF1	87,91	VEGF	WAF1	7422	1026	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|p21 p21|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
23123638	0	VEGF	58,62	YC-1	21,25	VEGF	YC-1	7422	5937	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	The anticancer agent YC-1 suppresses progestin-stimulated VEGF in breast_cancer cells and arrests breast_tumor development .
26882471	0	VEGF	17,21	ZEB1	0,4	VEGF	ZEB1	7422	6935	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast_Cancer .
24587407	0	VEGF	37,41	alpha-fetoprotein	10,27	VEGF	alpha-fetoprotein	7422	174	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Silencing alpha-fetoprotein inhibits VEGF and MMP-2 / 9 production in human hepatocellular_carcinoma cell .
20023214	0	VEGF	62,66	alphaB-crystallin	0,17	VEGF	alphaB-crystallin	22339(Tax:10090)	12955(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	alphaB-crystallin regulation of angiogenesis by modulation of VEGF .
21778999	0	VEGF	43,47	anaplastic_lymphoma_kinase	62,88	VEGF	anaplastic lymphoma kinase	7422	238	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic_lymphoma_kinase -LRB- ALK -RRB- - positive anaplastic_large-cell_lymphomas .
14601137	0	VEGF	49,53	angiopoietin-1	22,36	VEGF	angiopoietin-1	100008899(Tax:9986)	100342781(Tax:9986)	Gene	Gene	followed|nmod|START_ENTITY END_ENTITY|acl|followed	Pre-administration of angiopoietin-1 followed by VEGF induces functional and mature vascular formation in a rabbit ischemic model .
10403795	0	VEGF	78,82	angiopoietin-2	36,50	VEGF	angiopoietin-2	395909(Tax:9031)	395610(Tax:9031)	Gene	Gene	development|amod|START_ENTITY Characterization|nmod|development Characterization|nmod|Ang-2B Ang-2B|amod|END_ENTITY	Characterization of a novel form of angiopoietin-2 -LRB- Ang-2B -RRB- and expression of VEGF and angiopoietin-2 during chicken testicular development and regression .
21269615	0	VEGF	44,48	angiopoietin-2	50,64	VEGF	angiopoietin-2	7422	285	Gene	Gene	agonist|nmod|START_ENTITY agonist|amod|END_ENTITY	Effect of GnRH agonist and hCG treatment on VEGF , angiopoietin-2 , and VE-cadherin : trying to explain the link to ovarian_hyperstimulation_syndrome .
24928471	0	VEGF	33,37	angiopoietin-2	6,20	VEGF	angiopoietin-2	7422	285	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute_dengue_virus_infection .
25088418	0	VEGF	55,59	angiopoietin-2	8,22	VEGF	angiopoietin-2	7422	285	Gene	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	Role of angiopoietin-2 in adaptive_tumor resistance to VEGF signaling blockade .
25459946	0	VEGF	149,153	angiopoietin-2	43,57	VEGF	angiopoietin-2	7422	285	Gene	Gene	CrossMab|compound|START_ENTITY therapy|nmod|CrossMab free|nmod|therapy free|dobj|determination determination|amod|END_ENTITY	An immunodepletion procedure advances free angiopoietin-2 determination in human plasma samples during anti-cancer therapy with bispecific anti-Ang2 / VEGF CrossMab .
19521712	0	VEGF	111,115	angiotensin_II	86,100	VEGF	angiotensin II	7422	183	Gene	Gene	expression|compound|START_ENTITY reduced|nsubjpass|expression increases|acl:relcl|reduced increases|amod|END_ENTITY	Regulated expression of the renin-angiotensin-system in human granulosa lutein cells : angiotensin_II increases VEGF expression but its synthesis is reduced by hCG .
21968684	0	VEGF	110,114	aquaporin-4	14,25	VEGF	aquaporin-4	7422	361	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin-4 in human supratentorial_meningiomas with peritumoral brain_edema and correlation of VEGF with edema formation .
24330582	0	VEGF	37,41	aryl_hydrocarbon_receptor	3,28	VEGF	aryl hydrocarbon receptor	7422	196	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	An aryl_hydrocarbon_receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 .
15714461	0	VEGF	39,43	bFGF	55,59	VEGF	bFGF	7422	2247	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D_breast_cancer cell line under normoxic conditions : involvement of PI-3K / Akt and MEK1/ERK pathways .
16433046	0	VEGF	37,41	bFGF	43,47	VEGF	bFGF	7422	2247	Gene	Gene	levels|nmod|START_ENTITY Changes|nmod|levels Changes|appos|END_ENTITY	Changes in maternal plasma levels of VEGF , bFGF , TGF-beta1 , ET-1 and sKL during uncomplicated pregnancy , hypertensive pregnancy_and_gestational_diabetes .
16934908	0	VEGF	23,27	bFGF	38,42	VEGF	bFGF	7422	2247	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Enhanced expression of VEGF following bFGF inhibition in non-small_cell_lung_cancer cell lines .
21176170	0	VEGF	101,105	bFGF	143,147	VEGF	bFGF	7422	2247	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	The impact of hyperbaric oxygen therapy on serological values of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- .
26665394	0	VEGF	33,37	bFGF	27,31	VEGF	bFGF	7422	2247	Gene	Gene	SECRETION|compound|START_ENTITY END_ENTITY|appos|SECRETION	THE EFFECT OF IBUPROFEN ON bFGF , VEGF SECRETION AND CELL PROLIFERATION IN THE PRESENCE OF LPS IN HMEC-1 CELLS .
26712666	0	VEGF	120,124	bFGF	162,166	VEGF	bFGF	7422	2247	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Comparison of invasion by human microvascular endothelial cell lines in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- in a threedimensional -LRB- 3D -RRB- cell culture system .
9677468	0	VEGF	68,72	bFGF	110,114	VEGF	bFGF	7422	2247	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Independent expression of serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- in patients with carcinoma and sarcoma .
10845553	0	VEGF	62,66	bcl-2	0,5	VEGF	bcl-2	7422	596	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|proteins proteins|amod|END_ENTITY	bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung_cancer .
21233846	0	VEGF	71,75	bcl-2	29,34	VEGF	bcl-2	7422	596	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic_tumor cells .
9607631	0	VEGF	75,79	beta-1	123,129	VEGF	beta-1	7422	3779	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of macrophage production of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by hypoxia and transforming growth factor beta-1 .
10564161	0	VEGF	0,4	beta-catenin	44,56	VEGF	beta-catenin	281572(Tax:9913)	539003(Tax:9913)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|dysfunction dysfunction|amod|END_ENTITY	VEGF stimulates tyrosine phosphorylation of beta-catenin and small-pore endothelial barrier dysfunction .
16288908	0	VEGF	118,122	beta-catenin	31,43	VEGF	beta-catenin	83785(Tax:10116)	84353(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression signaling|nmod|induction promotes|xcomp|signaling promotes|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta / beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF , Bcl-2 and survivin expression in rat ischemic preconditioned myocardium .
19306293	0	VEGF	37,41	beta-catenin	21,33	VEGF	beta-catenin	7422	1499	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of beta-catenin in VEGF and histamine-induced MMP-2 production in microvascular endothelial cells .
20010698	0	VEGF	19,23	beta-catenin	33,45	VEGF	beta-catenin	22339(Tax:10090)	12387(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones .
23760290	0	VEGF	53,57	c-Fos	19,24	VEGF	c-Fos	7422	2353	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation .
23588859	0	VEGF	49,53	c-myc	0,5	VEGF	c-myc	7422	4609	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	c-myc but not Hif-1a-dependent downregulation of VEGF influences the proliferation and differentiation of HL-60 cells induced by ATRA .
17574778	0	VEGF	53,57	cathepsin_L	38,49	VEGF	cathepsin L	7422	1514	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of human cathepsin_L by VEGF in glioblastoma cells .
20720263	0	VEGF	59,63	caveolin-1	14,24	VEGF	caveolin-1	7422	857	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of caveolin-1 expression and phosphorylation by VEGF in ovine amnion cells .
23426970	0	VEGF	105,109	caveolin-1	22,32	VEGF	caveolin-1	7422	857	Gene	Gene	induces|nmod|START_ENTITY induces|xcomp|END_ENTITY	Dexamethasone induces caveolin-1 in vascular endothelial cells : implications for attenuated responses to VEGF .
17203162	0	VEGF	28,32	eIF4E	68,73	VEGF	eIF4E	7422	1977	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Expression levels of eIF4E , VEGF , and cyclin_D1 , and correlation of eIF4E with VEGF and cyclin_D1 in multi-tumor tissue microarray .
17203162	0	VEGF	79,83	eIF4E	21,26	VEGF	eIF4E	7422	1977	Gene	Gene	eIF4E|nmod|START_ENTITY levels|nmod|eIF4E levels|nmod|VEGF VEGF|compound|END_ENTITY	Expression levels of eIF4E , VEGF , and cyclin_D1 , and correlation of eIF4E with VEGF and cyclin_D1 in multi-tumor tissue microarray .
17113146	0	VEGF	60,64	eNOS	91,95	VEGF	eNOS	443103(Tax:9940)	443077(Tax:9940)	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Reduction of maternal adrenal steroids results in increased VEGF protein without increased eNOS in the ovine placenta .
10066445	0	VEGF	0,4	endothelial_nitric_oxide_synthase	49,82	VEGF	endothelial nitric oxide synthase	7422	4846	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|cells cells|compound|KDR KDR|advmod|END_ENTITY	VEGF induces nuclear translocation of Flk-1 / KDR , endothelial_nitric_oxide_synthase , and caveolin-1 in vascular endothelial cells .
16164642	0	VEGF	0,4	endothelial_nitric_oxide_synthase	19,52	VEGF	endothelial nitric oxide synthase	7422	4846	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	VEGF regulation of endothelial_nitric_oxide_synthase in glomerular endothelial cells .
25412937	0	VEGF	44,48	epidermal_growth_factor_receptor_2	74,108	VEGF	epidermal growth factor receptor 2	7422	2064	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	The single nucleotide polymorphism +936 _ C/T VEGF is associated with human epidermal_growth_factor_receptor_2 expression in Moroccan breast_cancer women .
10604730	0	VEGF	53,57	flk-1	78,83	VEGF	flk-1	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|dep|END_ENTITY	Co-expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- flk-1 and flt-1 -RRB- in hormone-induced mammary cancer in the Noble rat .
8126087	0	VEGF	35,39	flt	50,53	VEGF	flt	7422	2321	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors END_ENTITY|nsubj|expression	Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells .
8671397	0	VEGF	16,20	flt	53,56	VEGF	flt	7422	2321	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy .
10398412	0	VEGF	50,54	flt-1	89,94	VEGF	flt-1	281572(Tax:9913)	503620(Tax:9913)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|dep|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its corresponding receptors -LRB- flt-1 and flk-1 -RRB- in the bovine oviduct .
16432214	0	VEGF	43,47	flt-1	13,18	VEGF	flt-1	7422	2321	Gene	Gene	system|compound|START_ENTITY integrates|dobj|system integrates|nsubj|SNP SNP|nmod|promoter promoter|amod|END_ENTITY	A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network .
18478945	0	VEGF	111,115	flt-1	117,122	VEGF	flt-1	7422	2321	Gene	Gene	mRNA|nmod|START_ENTITY antisense|nmod|mRNA antisense|xcomp|END_ENTITY	-LSB- Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotide on mRNA and expression of VEGF , flt-1 , and kinase_insert_domain_containing_receptor and VEGF excretion in human gallbladder_carcinoma cells -RSB- .
18478945	0	VEGF	48,52	flt-1	117,122	VEGF	flt-1	7422	2321	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY Effects|nmod|vascular_endothelial_growth_factor antisense|nsubj|Effects antisense|xcomp|END_ENTITY	-LSB- Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotide on mRNA and expression of VEGF , flt-1 , and kinase_insert_domain_containing_receptor and VEGF excretion in human gallbladder_carcinoma cells -RSB- .
18482723	0	VEGF	24,28	flt-1	39,44	VEGF	flt-1	7422	2321	Gene	Gene	START_ENTITY|dobj|receptors receptors|amod|END_ENTITY	Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain_injury .
20030917	0	VEGF	43,47	flt-1	57,62	VEGF	flt-1	7422	2321	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Inhibition effect of short hairpin RNA on VEGF receptor flt-1 gene expression in leukemia cell line K562 -RSB- .
7535833	0	VEGF	72,76	flt-1	96,101	VEGF	flt-1	7422	2321	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|dep|END_ENTITY	-LSB- Expression and subtype analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor -LRB- flt-1 -RRB- in human ovarian_tumors -RSB- .
8605350	0	VEGF	80,84	flt-1	120,125	VEGF	flt-1	7422	2321	Gene	Gene	Migration|appos|START_ENTITY mediated|nsubjpass|Migration mediated|nmod|END_ENTITY	Migration of human monocytes in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- is mediated via the VEGF receptor flt-1 .
9777366	0	VEGF	84,88	flt-1	100,105	VEGF	flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	Evidence|appos|START_ENTITY receptors|nsubj|Evidence receptors|xcomp|END_ENTITY	Evidence for upregulation and redistribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors flt-1 and flk-1 in the oxygen-injured rat retina .
19284324	0	VEGF	22,26	glucocorticoid_receptor	42,65	VEGF	glucocorticoid receptor	7422	2908	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Fluocinolone inhibits VEGF expression via glucocorticoid_receptor in human retinal pigment epithelial -LRB- ARPE-19 -RRB- cells and TNF-alpha-induced angiogenesis in chick_chorioallantoic_membrane -LRB- CAM -RRB- .
14738567	0	VEGF	72,76	hTERT	23,28	VEGF	hTERT	7422	7015	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|expression expression|nmod|END_ENTITY	The mRNA expression of hTERT in human breast_carcinomas correlates with VEGF expression .
23869238	0	VEGF	50,54	hTERT	23,28	VEGF	hTERT	7422	7015	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|dep|Signaling	Berberine Targets AP-2 / hTERT , NF-kB/COX -2 , HIF-1a / VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth .
16512910	0	VEGF	0,4	hypoxia-induced_mitogenic_factor	23,55	VEGF	hypoxia-induced mitogenic factor	22339(Tax:10090)	57262(Tax:10090)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	VEGF is upregulated by hypoxia-induced_mitogenic_factor via the PI-3K / Akt-NF-kappaB signaling pathway .
20715173	0	VEGF	23,27	hypoxia-inducible_factor-1a	61,88	VEGF	hypoxia-inducible factor-1a	7422	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|mechanism mechanism|amod|END_ENTITY	Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible_factor-1a protein-dependent mechanism .
11321512	0	VEGF	48,52	iNOS	42,46	VEGF	iNOS	83785(Tax:10116)	24599(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Relation Relation|appos|END_ENTITY	Relation between expression of TNF_alpha , iNOS , VEGF mRNA and development of heart_failure after experimental myocardial_infarction in rats .
15050899	0	VEGF	67,71	iNOS	79,83	VEGF	iNOS	83785(Tax:10116)	24599(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Activation of the transcription factor HIF-1 and its target genes , VEGF , HO-1 , iNOS , during fracture repair .
19300368	0	VEGF	46,50	iNOS	40,44	VEGF	iNOS	7422	4843	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of pro-inflammatory protein , iNOS , VEGF and COX-2 in oral_squamous_cell_carcinoma -LRB- OSCC -RRB- , relationship with angiogenesis and their clinico-pathological correlation .
19307105	0	VEGF	14,18	iNOS	96,100	VEGF	iNOS	7422	4843	Gene	Gene	expression|compound|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|gene gene|amod|END_ENTITY	Inhibition of VEGF expression in tongue_squamous_cancer cells via RNA interference silencing of iNOS gene .
25065562	0	VEGF	29,33	iNOS	98,102	VEGF	iNOS	7422	4843	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression study|nmod|inhibition study|nmod|cells cells|nmod|RNAi RNAi|compound|END_ENTITY	A study on the inhibition of VEGF expression in salivary_gland_adenoid_cystic_carcinoma cells via iNOS gene RNAi in vitro .
26635115	0	VEGF	50,54	iNOS	93,97	VEGF	iNOS	7422	4843	Gene	Gene	Vascular_Endothelial_Growth_Factor|appos|START_ENTITY Vascular_Endothelial_Growth_Factor|appos|END_ENTITY	Uncoupling of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- and Inducible Nitric_Oxide Synthase -LRB- iNOS -RRB- in Gingival Tissue of Type 2 Diabetic Patients .
19040082	0	VEGF	22,26	insulin	11,18	VEGF	insulin	281572(Tax:9913)	280829(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of insulin on VEGF expression in bovine retinal microvascular endothelial cells exposed to normal or high glucose -RSB- .
17725274	0	VEGF	79,83	interleukin_6	121,134	VEGF	interleukin 6	7422	3569	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
21404021	0	VEGF	68,72	lactoferrin	12,23	VEGF	lactoferrin	22339(Tax:10090)	17002(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Bovine milk lactoferrin induces synthesis of the angiogenic factors VEGF and FGF2 in osteoblasts via the p44/p42 MAP kinase pathway .
15841796	0	VEGF	83,87	leptin	10,16	VEGF	leptin	22339(Tax:10090)	16846(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of leptin on proliferative activity and vascular endothelial growth factor -LRB- VEGF -RRB- secretion from cultured endothelial cells HECa10 in vitro .
15383417	0	VEGF	75,79	matrix_metalloproteinase-9	84,110	VEGF	matrix metalloproteinase-9	7422	4318	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	The combination assay with circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- - C , matrix_metalloproteinase-9 , and VEGF for diagnosing lymph node metastasis in patients with non-small_cell_lung_cancer .
15735762	0	VEGF	50,54	metallothionein_1G	19,37	VEGF	metallothionein 1G	7422	4495	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Induction of human metallothionein_1G promoter by VEGF and heavy metals : differential involvement of E2F and metal transcription factors .
20232316	0	VEGF	18,22	miR-20b	0,7	VEGF	miR-20b	7422	574032	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	miR-20b modulates VEGF expression by targeting HIF-1_alpha and STAT3 in MCF-7 breast_cancer cells .
22776647	0	VEGF	43,47	miR-663	19,26	VEGF	miR-663	7422	724033	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids .
11756651	0	VEGF	75,79	neuropilin-1	23,35	VEGF	neuropilin-1	22339(Tax:10090)	18186(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	Selective induction of neuropilin-1 by vascular_endothelial_growth_factor -LRB- VEGF -RRB- : a mechanism contributing to VEGF-induced angiogenesis .
12453880	0	VEGF	129,133	neuropilin-1	96,108	VEGF	neuropilin-1	22339(Tax:10090)	18186(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY predicts|dobj|role predicts|nsubj|administration administration|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|amod|END_ENTITY	In vivo administration of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its antagonist , soluble neuropilin-1 , predicts a role of VEGF in the progression of acute_myeloid_leukemia in vivo .
12453880	0	VEGF	62,66	neuropilin-1	96,108	VEGF	neuropilin-1	22339(Tax:10090)	18186(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|amod|END_ENTITY	In vivo administration of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its antagonist , soluble neuropilin-1 , predicts a role of VEGF in the progression of acute_myeloid_leukemia in vivo .
15233640	0	VEGF	36,40	neuropilin-1	51,63	VEGF	neuropilin-1	7422	8829	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor neuropilin-1 's distribution in astrocytic_tumors .
15708957	0	VEGF	24,28	neuropilin-1	76,88	VEGF	neuropilin-1	7422	8829	Gene	Gene	Differential|nmod|START_ENTITY isoforms|nsubj|Differential isoforms|xcomp|VEGF VEGF|dobj|receptor receptor|nmod|presence presence|nmod|END_ENTITY	Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1 : a computational model .
15708957	0	VEGF	41,45	neuropilin-1	76,88	VEGF	neuropilin-1	7422	8829	Gene	Gene	START_ENTITY|dobj|receptor receptor|nmod|presence presence|nmod|END_ENTITY	Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1 : a computational model .
16289960	0	VEGF	125,129	neuropilin-1	16,28	VEGF	neuropilin-1	7422	8829	Gene	Gene	vascular|nmod|START_ENTITY enhances|xcomp|vascular enhances|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of neuropilin-1 by basic_fibroblast_growth_factor enhances vascular smooth muscle cell migration in response to VEGF .
17196035	0	VEGF	34,38	neuropilin-1	10,22	VEGF	neuropilin-1	7422	8829	Gene	Gene	inhibit|dobj|START_ENTITY END_ENTITY|xcomp|inhibit	Targeting neuropilin-1 to inhibit VEGF signaling in cancer : Comparison of therapeutic approaches .
17917967	0	VEGF	46,50	neuropilin-1	71,83	VEGF	neuropilin-1	7422	8829	Gene	Gene	receptors|amod|START_ENTITY receptors|nmod|NRP-1 NRP-1|amod|END_ENTITY	Myeloid_leukemias express a broad spectrum of VEGF receptors including neuropilin-1 -LRB- NRP-1 -RRB- and NRP-2 .
17983687	0	VEGF	77,81	neuropilin-1	98,110	VEGF	neuropilin-1	7422	8829	Gene	Gene	START_ENTITY|amod|binding binding|nmod|simulations simulations|amod|END_ENTITY	Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF -LRB- 165 -RRB- binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin -1 complex .
23447383	0	VEGF	4,8	neuropilin-1	19,31	VEGF	neuropilin-1	7422	8829	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The VEGF receptor , neuropilin-1 , represents a promising novel target for chronic_lymphocytic_leukemia patients .
26804176	0	VEGF	103,107	neuropilin-1	23,35	VEGF	neuropilin-1	7422	8829	Gene	Gene	signaling|compound|START_ENTITY induction|nmod|signaling role|nmod|induction association|dep|role association|nmod|END_ENTITY	A novel association of neuropilin-1 and MUC1 in pancreatic_ductal_adenocarcinoma : role in induction of VEGF signaling and angiogenesis .
16775835	0	VEGF	71,75	p110_alpha	47,57	VEGF	p110 alpha	7422	5290	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of angiogenesis and tumor growth by p110_alpha and AKT1 via VEGF expression .
16204053	0	VEGF	64,68	p16	145,148	VEGF	p16	22339(Tax:10090)	12578(Tax:10090)	Gene	Gene	latent|dep|START_ENTITY latent|nmod|up-regulation up-regulation|nmod|END_ENTITY	Epstein-Barr_virus latent membrane protein 1 -LRB- CAO -RRB- up-regulates VEGF and TGF_alpha concomitant with hyperlasia , with subsequent up-regulation of p16 and MMP9 .
16998811	0	VEGF	43,47	p16	60,63	VEGF	p16	7422	1029	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
20307196	0	VEGF	14,18	p16	0,3	VEGF	p16	22339(Tax:10090)	12578(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Modulates Modulates|amod|END_ENTITY	p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast_cancer cells .
16998811	0	VEGF	43,47	p21	83,86	VEGF	p21	7422	1026	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
16998811	0	VEGF	43,47	p27	72,75	VEGF	p27	7422	3429	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
22522454	0	VEGF	54,58	p38	73,76	VEGF	p38	7422	1432	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	TGF-b1 induces endothelial cell apoptosis by shifting VEGF activation of p38 -LRB- MAPK -RRB- from the prosurvival p38b to proapoptotic p38a .
11500937	0	VEGF	53,57	p38_MAP_kinase	15,29	VEGF	p38 MAP kinase	83785(Tax:10116)	81649(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Involvement of p38_MAP_kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells .
11030150	0	VEGF	110,114	p53	135,138	VEGF	p53	7422	22060(Tax:10090)	Gene	Gene	factor|appos|START_ENTITY promoter|compound|factor promoter|nmod|manner manner|compound|END_ENTITY	Oncogenes and tumor angiogenesis : the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor -LRB- VEGF -RRB- gene promoter in a p53 independent manner .
11710596	0	VEGF	29,33	p53	87,90	VEGF	p53	7422	7157	Gene	Gene	expression|amod|START_ENTITY study|nmod|expression study|dep|comparison comparison|nmod|expression expression|compound|END_ENTITY	Immunohistochemical study on VEGF expression in endometrial_carcinoma -- comparison with p53 expression , angiogenesis , and tumor histologic grade .
11720743	0	VEGF	50,54	p53	112,115	VEGF	p53	7422	7157	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY Expression|nmod|vascular_endothelial_growth_factor Expression|dep|association association|nmod|mutation mutation|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in non-small_cell_lung_cancer -LRB- NSCLC -RRB- : association with p53 gene mutation and prognosis .
12168898	0	VEGF	36,40	p53	69,72	VEGF	p53	7422	7157	Gene	Gene	Vascular_endothelial_growth_factor|appos|START_ENTITY expression|nsubj|Vascular_endothelial_growth_factor expression|nmod|expressions expressions|compound|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression correlates with p53 and ki-67 expressions in tongue_squamous_cell_carcinoma .
12901974	0	VEGF	50,54	p53	7,10	VEGF	p53	7422	7157	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Mutant p53 in bone marrow stromal cells increases VEGF expression and supports leukemia cell growth .
15142681	0	VEGF	0,4	p53	107,110	VEGF	p53	7422	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|status status|compound|END_ENTITY	VEGF and bFGF expression and microvessel density of maxillary_sinus_squamous_cell_carcinoma in relation to p53 status , spontaneous apoptosis and prognosis .
15142682	0	VEGF	81,85	p53	15,18	VEGF	p53	7422	7157	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY Correlation|nmod|vascular_endothelial_growth_factor Correlation|nmod|expression expression|compound|END_ENTITY	Correlation of p53 and bcl-2 expression with vascular_endothelial_growth_factor -LRB- VEGF -RRB- , microvessel density -LRB- MVD -RRB- and clinico-pathological features in colon_cancer .
15221598	0	VEGF	78,82	p53	30,33	VEGF	p53	7422	7157	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY Correlation|appos|vascular_endothelial_growth_factor Correlation|nmod|END_ENTITY	Correlation and expression of p53 , HER-2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and e-cadherin in a high-risk breast-cancer population .
16432214	0	VEGF	43,47	p53	64,67	VEGF	p53	7422	7157	Gene	Gene	system|compound|START_ENTITY integrates|dobj|system integrates|nmod|network network|compound|END_ENTITY	A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network .
16684540	0	VEGF	65,69	p53	103,106	VEGF	p53	7422	7157	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nmod|decrease decrease|nmod|activity activity|compound|END_ENTITY	Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity .
16943578	0	VEGF	38,42	p53	10,13	VEGF	p53	7422	7157	Gene	Gene	production|nmod|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Antisense p53 decreases production of VEGF in follicular thyroid_cancer cells .
16998811	0	VEGF	43,47	p53	55,58	VEGF	p53	7422	7157	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
18646041	0	VEGF	18,22	p53	51,54	VEGF	p53	7422	7157	Gene	Gene	Overexpression|nmod|START_ENTITY associated|nsubjpass|Overexpression associated|nmod|END_ENTITY	Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular_carcinoma -LRB- HCC -RRB- and adverse outcome of HCC patients .
19292920	0	VEGF	135,139	p53	177,180	VEGF	p53	83785(Tax:10116)	301300(Tax:10116)	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Gamma-linolenic_acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6_glioma model through changes in VEGF , Flt1 , ERK1/2 , MMP2 , cyclin_D1 , pRb , p53 and p27 protein expression .
23449391	0	VEGF	13,17	p53	0,3	VEGF	p53	7422	7157	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway .
11704858	0	VEGF	29,33	p73	0,3	VEGF	p73	7422	7161	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	p73 Overexpression increases VEGF and reduces thrombospondin-1 production : implications for tumor angiogenesis .
22069106	0	VEGF	36,40	part_1	44,50	VEGF	part 1	7422	25859	Gene	Gene	Vascular_endothelial_growth_factor|appos|START_ENTITY Vascular_endothelial_growth_factor|dep|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - part_1 : in physiology and pathophysiology .
15501243	0	VEGF	58,62	placenta_growth_factor	14,36	VEGF	placenta growth factor	7422	5228	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of placenta_growth_factor is regulated by both VEGF and hyperglycaemia via VEGFR-2 .
15613498	0	VEGF	31,35	retinoic_acid_receptor-alpha	74,102	VEGF	retinoic acid receptor-alpha	281572(Tax:9913)	534280(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Visible light exposure induces VEGF gene expression through activation of retinoic_acid_receptor-alpha in retinoblastoma Y79 cells .
25329693	0	VEGF	12,16	sFLT1	35,40	VEGF	sFLT1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications .
14528319	0	VEGF	31,35	sFlt-1	48,54	VEGF	sFlt-1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Adenoviral delivery of soluble VEGF receptor 1 -LRB- sFlt-1 -RRB- abrogates disease activity in murine collagen-induced_arthritis .
16234975	0	VEGF	0,4	sFlt1	23,28	VEGF	sFlt1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	improves|nsubj|START_ENTITY improves|advcl|inhibits inhibits|nsubj|END_ENTITY	VEGF improves , whereas sFlt1 inhibits , BMP2-induced bone formation and bone healing through modulation of angiogenesis .
21548585	0	VEGF	20,24	sFlt1	37,42	VEGF	sFlt1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	Delivery|nmod|START_ENTITY receptor|nsubj|Delivery receptor|dobj|1 1|appos|END_ENTITY	Delivery of soluble VEGF receptor 1 -LRB- sFlt1 -RRB- by gene electrotransfer as a new antiangiogenic cancer therapy .
18283262	0	VEGF	63,67	somatostatin	11,23	VEGF	somatostatin	7422	6750	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of somatostatin on vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from non-functioning pituitary tumoral cells incubated in vitro .
24601228	0	VEGF	16,20	t-PA	0,4	VEGF	t-PA	7422	5327	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	t-PA stimulates VEGF expression in endothelial cells via ERK2/p38 signaling pathways .
16914140	0	VEGF	186,190	tTG	54,57	VEGF	tTG	7422	7052	Gene	Gene	mechanism|nmod|START_ENTITY formation|dep|mechanism formation|nmod|II II|appos|END_ENTITY	Complex formation between tissue_transglutaminase II -LRB- tTG -RRB- and vascular_endothelial_growth_factor_receptor_2 -LRB- VEGFR-2 -RRB- : proposed mechanism for modulation of endothelial cell response to VEGF .
11704858	0	VEGF	29,33	thrombospondin-1	46,62	VEGF	thrombospondin-1	7422	7057	Gene	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	p73 Overexpression increases VEGF and reduces thrombospondin-1 production : implications for tumor angiogenesis .
19861314	0	VEGF	114,118	transforming_growth_factor-beta-1	28,61	VEGF	transforming growth factor-beta-1	7422	7040	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Functional polymorphisms in transforming_growth_factor-beta-1 -LRB- TGFbeta-1 -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- genes modify risk of renal_parenchymal_scarring following childhood urinary_tract_infection .
15330186	0	VEGF	73,77	tumor	53,58	VEGF	COX-2	7422	4513	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Survival in small_cell_lung_cancer is independent of tumor expression of VEGF and COX-2 .
17725274	0	VEGF	79,83	tumor_necrosis_factor	86,107	VEGF	tumor necrosis factor	7422	7124	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
10719731	0	VEGF	44,48	vascular-endothelial-growth-factor	8,42	VEGF	vascular-endothelial-growth-factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p53 and vascular-endothelial-growth-factor -LRB- VEGF -RRB- expression predicts outcome in 833 patients with primary breast_carcinoma .
10748050	0	VEGF	126,130	vascular_endothelial_cell_growth_factor	85,124	VEGF	vascular endothelial cell growth factor	7422	7422	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- receptor mRNAs by VEGF .
24574253	0	VEGF	68,72	vascular_endothelial_cell_growth_factor	27,66	VEGF	vascular endothelial cell growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive expression of vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- gene family ligand and receptors on human upper and lower airway epithelial cells .
10408392	0	VEGF	130,134	vascular_endothelial_growth_factor	94,128	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA in cervical_cancer cell lines .
10452500	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in human thyroid_neoplasms .
10454244	0	VEGF	87,91	vascular_endothelial_growth_factor	51,85	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Progestins suppress estrogen-induced expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- subtypes in uterine endometrial_cancer cells .
10674116	0	VEGF	110,114	vascular_endothelial_growth_factor	74,108	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Therapeutic angiogenesis through intramuscular injection of the gene for vascular_endothelial_growth_factor -LRB- VEGF -RRB- -RSB- .
10801078	0	VEGF	48,52	vascular_endothelial_growth_factor	12,46	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in abnormal vascular changes in the adult rat eye .
10804088	0	VEGF	48,52	vascular_endothelial_growth_factor	12,46	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in AIDS-related Kaposi 's _ sarcoma .
10930302	0	VEGF	79,83	vascular_endothelial_growth_factor	43,77	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of polymorphisms within the vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene : correlation with variation in VEGF protein production .
10952783	0	VEGF	56,60	vascular_endothelial_growth_factor	20,54	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in head and neck squamous_cell_carcinomas .
10954034	0	VEGF	44,48	vascular_endothelial_growth_factor	8,42	VEGF	vascular endothelial growth factor	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in endothelial cell protection against cytotoxic agents .
10995484	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene transcription by estrogen receptors alpha and beta .
11188930	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- as a novel approach for cancer therapy .
11261591	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Postnatal changes of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the retinae of normal and hypertensive rats .
11286562	0	VEGF	64,68	vascular_endothelial_growth_factor	28,62	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors and VEGF binding in ovine placenta and fetal membranes .
11299827	0	VEGF	77,81	vascular_endothelial_growth_factor	30,64	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Microvessel density -LRB- MVD -RRB- and vascular_endothelial_growth_factor expression -LRB- VEGF -RRB- in human oral_squamous_cell_carcinoma .
11344490	0	VEGF	53,57	vascular_endothelial_growth_factor	17,51	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Concentration|appos|START_ENTITY Concentration|nmod|END_ENTITY	Concentration of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the serum of patients with malignant_bone_tumors .
11423976	0	VEGF	65,69	vascular_endothelial_growth_factor	29,63	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Ionizing radiation modulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression through multiple mitogen activated protein kinase dependent pathways .
11571674	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Peripheral levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- are higher in gonadotropin stimulated as compared to natural ovarian cycles .
11578859	0	VEGF	48,52	vascular_endothelial_growth_factor	12,46	VEGF	vascular endothelial growth factor	30682(Tax:7955)	30682(Tax:7955)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in vasculogenesis , angiogenesis , and hematopoiesis in zebrafish development .
11732982	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors in rat corpus luteum : regulation by oestradiol during mid-pregnancy .
11777931	0	VEGF	82,86	vascular_endothelial_growth_factor	46,80	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Paracrine and autocrine functions of neuronal vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the central nervous system .
11827068	0	VEGF	51,55	vascular_endothelial_growth_factor	15,49	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differences of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression between liver and abdominal metastases from colon_cancer .
11896832	0	VEGF	55,59	vascular_endothelial_growth_factor	19,53	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Salivary levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in recurrent aphthous ulceration .
11970755	0	VEGF	48,52	vascular_endothelial_growth_factor	12,46	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in tumor angiogenesis and early clinical development of VEGF-receptor kinase inhibitors .
11973650	0	VEGF	59,63	vascular_endothelial_growth_factor	23,57	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- plays a critical role in the tumor progression potential induced by simian_virus_40 large T antigen .
12163680	0	VEGF	55,59	vascular_endothelial_growth_factor	19,53	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	Green tea inhibits vascular_endothelial_growth_factor -LRB- VEGF -RRB- induction in human breast_cancer cells .
12228014	0	VEGF	43,47	vascular_endothelial_growth_factor	7,41	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Plasma vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA .
12411422	0	VEGF	60,64	vascular_endothelial_growth_factor	24,58	VEGF	vascular endothelial growth factor	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	Inhibitory mechanism of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by bucillamine .
12445161	0	VEGF	131,135	vascular_endothelial_growth_factor	95,129	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in human glioblastomas correlates with vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
12476614	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in human thyroid_tumors .
12497000	0	VEGF	52,56	vascular_endothelial_growth_factor	16,50	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in prostate_disease .
12668286	0	VEGF	68,72	vascular_endothelial_growth_factor	32,66	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The significance of circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in gastric_cancer .
12684411	0	VEGF	54,58	vascular_endothelial_growth_factor	18,52	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of soluble vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor 1 in astrocytic_tumors and its relation to malignancy , vascularity , and VEGF-A .
12839674	0	VEGF	51,55	vascular_endothelial_growth_factor	15,49	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- C and VEGF receptor 3 in non-small_cell_lung_cancer -RSB- .
12871881	0	VEGF	46,50	vascular_endothelial_growth_factor	10,44	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Levels|appos|START_ENTITY Levels|nmod|END_ENTITY	Levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in serum of patients with endometriosis .
12917032	0	VEGF	45,49	vascular_endothelial_growth_factor	9,43	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	-LSB- Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in development and progress of refractory acute_myeloid_leukemia -RSB- .
12924491	0	VEGF	88,92	vascular_endothelial_growth_factor	52,86	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Effects of oxygen administration on the circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in patients with obstructive_sleep_apnea_syndrome .
14518267	0	VEGF	54,58	vascular_endothelial_growth_factor	18,52	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- concentration in serum of patients with colorectal_carcinoma -RSB- .
14600832	0	VEGF	53,57	vascular_endothelial_growth_factor	17,51	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	Determination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- overexpression in soft tissue sarcomas and the role of overexpression in leiomyosarcoma .
14666713	0	VEGF	73,77	vascular_endothelial_growth_factor	37,71	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	determination|appos|START_ENTITY determination|nmod|END_ENTITY	Immunohistochemical determination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- overexpression in malignant_melanoma .
14746189	0	VEGF	49,53	vascular_endothelial_growth_factor	13,47	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	-LSB- The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- -RSB- .
14990072	0	VEGF	1,5	vascular_endothelial_growth_factor	59,93	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	-LSB- VEGF antisense oligonucleotide inhibits the expression of vascular_endothelial_growth_factor in human leukemic cell lines -RSB- .
15050460	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Umbilical cord serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in normal pregnancies and in pregnancies complicated by preterm_delivery or pre-eclampsia .
15053061	0	VEGF	47,51	vascular_endothelial_growth_factor	11,45	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in vascular_endothelial_growth_factor -LRB- VEGF -RRB- after chemoendocrine therapy in breast_cancer .
15066146	0	VEGF	63,67	vascular_endothelial_growth_factor	27,61	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- upon dopaminergic neurons in a rat model of Parkinson 's _ disease .
15149314	0	VEGF	48,52	vascular_endothelial_growth_factor	12,46	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in renal pathophysiology .
15157322	0	VEGF	58,62	vascular_endothelial_growth_factor	22,56	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- Inhibiting effect of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotides on VEGF expression in U937 cell -RSB- .
15200265	0	VEGF	64,68	vascular_endothelial_growth_factor	28,62	VEGF	vascular endothelial growth factor	403802(Tax:9615)	403802(Tax:9615)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Preliminary study of plasma vascular_endothelial_growth_factor -LRB- VEGF -RRB- during low - and high-dose radiation therapy of dogs with spontaneous tumors .
15350962	0	VEGF	47,51	vascular_endothelial_growth_factor	11,45	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on motor neuron_degeneration .
15583935	0	VEGF	163,167	vascular_endothelial_growth_factor	127,161	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Anti-angiogenic effects of SN38 -LRB- active metabolite of irinotecan -RRB- : inhibition of hypoxia-inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- / vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression of glioma and growth of endothelial cells .
15646494	1	VEGF	82,86	vascular_endothelial_growth_factor	46,80	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- -RSB- .
15673292	0	VEGF	73,77	vascular_endothelial_growth_factor	37,71	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	functions|appos|START_ENTITY functions|nmod|END_ENTITY	Autocrine and paracrine functions of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in renal tubular epithelial cells .
15702434	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- does not affect early renal changes in a rat model of lean type 2 diabetes .
15716999	0	VEGF	61,65	vascular_endothelial_growth_factor	25,59	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in sera of patients with pediatric_malignancies .
15760668	0	VEGF	72,76	vascular_endothelial_growth_factor	36,70	VEGF	vascular endothelial growth factor	397157(Tax:9823)	397157(Tax:9823)	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Fasting influences steroidogenesis , vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels and mRNAs expression for VEGF , VEGF receptor type 2 -LRB- VEGFR-2 -RRB- , endothelin-1 -LRB- ET-1 -RRB- , endothelin_receptor_type_A -LRB- ET-A -RRB- and endothelin_converting_enzyme-1 -LRB- ECE-1 -RRB- in newly formed pig corpora lutea .
15921007	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in vulvar_squamous_cancer and VIN .
15985268	0	VEGF	113,117	vascular_endothelial_growth_factor	77,111	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16144770	0	VEGF	48,52	vascular_endothelial_growth_factor	12,46	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in oral_dysplasia and oral_squamous_cell_carcinoma .
16267616	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by the ER-alpha variant , ERDelta3 .
16394178	0	VEGF	54,58	vascular_endothelial_growth_factor	18,52	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16468311	0	VEGF	60,64	vascular_endothelial_growth_factor	24,58	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Targeted inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human osteosarcoma cell line by antisense VEGF165 cDNA promoted by hypoxia reaction element -RSB- .
16496371	0	VEGF	122,126	vascular_endothelial_growth_factor	86,120	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Correlations of oral_tongue_cancer invasion with matrix metalloproteinases -LRB- MMPs -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
16801663	0	VEGF	77,81	vascular_endothelial_growth_factor	41,75	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Possible gender-dependent association of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene and ALS .
16835467	0	VEGF	60,64	vascular_endothelial_growth_factor	24,58	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Signal transduction via vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors and their roles in atherogenesis .
16954806	0	VEGF	48,52	vascular_endothelial_growth_factor	12,46	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in inflammatory_bowel_disease .
16981238	0	VEGF	64,68	vascular_endothelial_growth_factor	28,62	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	TLR-2-mediated induction of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in cartilage in septic_joint_disease .
17031660	0	VEGF	56,60	vascular_endothelial_growth_factor	20,54	VEGF	vascular endothelial growth factor	100462897	100462897	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fast alterations of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and that of its receptors -LRB- Flt-1 , Flk-1 and Neuropilin -RRB- in the cochlea of guinea_pigs after moderate noise exposure .
17065408	0	VEGF	52,56	vascular_endothelial_growth_factor	16,50	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Localization of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors in normal and adenomatous_pituitaries : detection of a non-endothelial function of VEGF in pituitary_tumours .
17070126	0	VEGF	132,136	vascular_endothelial_growth_factor	96,130	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Growth and differentiation factor-5 -LRB- GDF-5 -RRB- stimulates osteogenic differentiation and increases vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in fat-derived stromal cells in vitro .
17127464	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor , VEGF , gene promoter by the tumor suppressor , WT1 .
17141472	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in normal oral mucosa , oral_dysplasia and oral_squamous_cell_carcinoma .
17275223	0	VEGF	75,79	vascular_endothelial_growth_factor	39,73	VEGF	vascular endothelial growth factor	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Progesterone induces the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- 120 and Flk-1 , its receptor , in bovine granulosa cells .
17683807	0	VEGF	82,86	vascular_endothelial_growth_factor	46,80	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vasoactive intestinal peptide -LRB- VIP -RRB- increases vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and secretion in human breast_cancer cells .
17822316	0	VEGF	70,74	vascular_endothelial_growth_factor	34,68	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- does not correlate with microvessel density in renal_cell_carcinoma .
18273500	0	VEGF	70,74	vascular_endothelial_growth_factor	34,68	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in intestinal type gastric_carcinoma .
18301455	0	VEGF	70,74	vascular_endothelial_growth_factor	34,68	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Immunohistochemical evaluation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in colorectal_carcinoma .
18317965	0	VEGF	42,46	vascular_endothelial_growth_factor	6,40	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels correlate with tumor VEGF and p53 overexpression in endocrine positive primary breast_cancer .
18317965	0	VEGF	76,80	vascular_endothelial_growth_factor	6,40	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|compound|END_ENTITY	Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels correlate with tumor VEGF and p53 overexpression in endocrine positive primary breast_cancer .
18419602	0	VEGF	54,58	vascular_endothelial_growth_factor	18,52	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Overexpression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors on keratinocytes in psoriasis : regulated by calcium independent of VEGF .
18546007	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	system|appos|START_ENTITY system|amod|END_ENTITY	The clinical role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- system in the pathogenesis of retinopathy_of_prematurity .
19112107	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	CXCL8/IL8 stimulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM -LRB- Carma3/Bcl10/Malt1 -RRB- complex .
19486605	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	100860957	100860957	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor in goat ovaries and improvement of in vitro caprine preantral follicle survival and growth with VEGF .
19734078	0	VEGF	81,85	vascular_endothelial_growth_factor	45,79	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Investigating the differential activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors .
19764591	0	VEGF	73,77	vascular_endothelial_growth_factor	37,71	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	-LSB- Prognostic significance of cellular vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the course of chronic_myeloid_leukaemia -RSB- .
19834063	0	VEGF	71,75	vascular_endothelial_growth_factor	35,69	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of increased renal tubular vascular_endothelial_growth_factor -LRB- VEGF -RRB- on fibrosis , cyst_formation , _ and_glomerular_disease .
19899967	0	VEGF	92,96	vascular_endothelial_growth_factor	56,90	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effect of zeaxanthin and antioxidant supplementation on vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in apolipoprotein-E deficient mice .
19967101	0	VEGF	49,53	vascular_endothelial_growth_factor	13,47	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on gastroprotection in stress-induced gastric_mucosal_ulcers in rats .
20156197	0	VEGF	10,14	vascular_endothelial_growth_factor	16,50	VEGF	vascular endothelial growth factor	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of VEGF -LRB- vascular_endothelial_growth_factor -RRB- on expression of IL-8 -LRB- interleukin-8 -RRB- , IL-1beta and their receptors in bovine theca cells .
20417686	0	VEGF	60,64	vascular_endothelial_growth_factor	24,58	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Direct survival role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on rat ovarian follicular cells .
20563616	0	VEGF	70,74	vascular_endothelial_growth_factor	34,68	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in different types_of_odontogenic_cysts .
20819828	0	VEGF	42,46	vascular_endothelial_growth_factor	6,40	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels correlate with number and location of micrometastases in a murine model of uveal_melanoma .
20976598	0	VEGF	82,86	vascular_endothelial_growth_factor	46,80	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Microencapsulated myoblasts transduced by the vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene for the ischemic skin flap .
21040465	0	VEGF	47,51	vascular_endothelial_growth_factor	11,45	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on MC3T3-E1 .
21273213	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- is sufficient to completely restore barrier malfunction induced by growth factors in microvascular retinal endothelial cells .
21378364	0	VEGF	54,58	vascular_endothelial_growth_factor	18,52	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene in epithelial_ovarian_cancer : an approach to anti-VEGF therapy .
21487788	0	VEGF	126,130	vascular_endothelial_growth_factor	8,42	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Soluble vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-1 inhibits migration of human monocytic THP-1 cells in response to VEGF .
21696760	0	VEGF	71,75	vascular_endothelial_growth_factor	35,69	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Mesenchymal-specific inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- attenuates growth in neonatal mice .
21703259	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced endothelial proliferation , arterial relaxation , vascular permeability and angiogenesis by dobesilate .
21969375	0	VEGF	67,71	vascular_endothelial_growth_factor	31,65	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	b-hairpin peptide that targets vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors : design , NMR characterization , and biological activity .
21978756	0	VEGF	53,57	vascular_endothelial_growth_factor	17,51	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	The influence of vascular_endothelial_growth_factor -LRB- VEGF -RRB- polymorphism on the progression of chronic glomerulonephritides .
22056013	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- transcript and protein in the testis of several vertebrates , including endangered species .
22153388	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Atorvastatin reduces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human non-small_cell_lung_carcinomas -LRB- NSCLCs -RRB- via inhibition of reactive oxygen species -LRB- ROS -RRB- production .
22272053	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- associated with histopathological changes in rodent models of osteoarthritis .
22286233	0	VEGF	47,51	vascular_endothelial_growth_factor	11,45	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in vascular_endothelial_growth_factor -LRB- VEGF -RRB- induced by the Morris water maze task .
22379030	0	VEGF	96,100	vascular_endothelial_growth_factor	40,74	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	IL-17A differentially regulates corneal vascular_endothelial_growth_factor -LRB- VEGF -RRB- - A and soluble VEGF receptor 1 expression and promotes corneal_angiogenesis_after_herpes_simplex_virus_infection .
22534085	0	VEGF	133,137	vascular_endothelial_growth_factor	97,131	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Paraneoplastic_symptoms : cachexia , polycythemia , and hypercalcemia are , respectively , related to vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in renal_clear_cell_carcinoma .
22558473	0	VEGF	63,67	vascular_endothelial_growth_factor	27,61	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expressional evaluation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in urinary_bladder_carcinoma patients exposed to cigarette smoke .
22925497	0	VEGF	52,56	vascular_endothelial_growth_factor	16,50	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The relation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle_cell_disease .
22992725	0	VEGF	128,132	vascular_endothelial_growth_factor	92,126	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in non-small_cell_lung_cancer .
23061308	0	VEGF	49,53	vascular_endothelial_growth_factor	13,47	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Study of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and microvascular density -LRB- MVD -RRB- in primary colorectal_cancer specimens .
23161411	0	VEGF	93,97	vascular_endothelial_growth_factor	57,91	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association between bevacizumab-related hypertension and vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms in Japanese patients with metastatic colorectal_cancer .
23456015	0	VEGF	77,81	vascular_endothelial_growth_factor	41,75	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic and predictive value of serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- in squamous_cell_carcinoma of the head_and_neck .
23459872	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of autocrine vascular_endothelial_growth_factor -LRB- VEGF -RRB- in non-small_cell_lung_cancer cell line A549 .
23719599	0	VEGF	95,99	vascular_endothelial_growth_factor	15,49	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphism and increased serum VEGF concentration with pancreatic_adenocarcinoma .
23758212	0	VEGF	53,57	vascular_endothelial_growth_factor	17,51	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of salivary vascular_endothelial_growth_factor -LRB- VEGF -RRB- in palatal_mucosal_wound healing .
23780896	0	VEGF	145,149	vascular_endothelial_growth_factor	109,143	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Paraneoplastic hormones : parathyroid_hormone-related_protein -LRB- PTHrP -RRB- and erythropoietin -LRB- EPO -RRB- are related to vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in clear_cell_renal_cell_carcinoma .
23926105	0	VEGF	172,176	vascular_endothelial_growth_factor	136,170	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Loss of epigenetic Kruppel-like factor 4 histone deacetylase -LRB- KLF-4-HDAC -RRB- - mediated transcriptional suppression is crucial in increasing vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in breast_cancer .
24240584	0	VEGF	65,69	vascular_endothelial_growth_factor	29,63	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Positive association between vascular_endothelial_growth_factor -LRB- VEGF -RRB- -2578 _ C/A variant and prostate_cancer .
24557071	0	VEGF	59,63	vascular_endothelial_growth_factor	23,57	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- 120 in parthenogenetic porcine placentas .
24601908	0	VEGF	72,76	vascular_endothelial_growth_factor	36,70	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Protective or pathogenic effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- as potential biomarker in cerebral_malaria .
24833243	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in patients with oral_squamous_cell_carcinoma and its clinical significance .
24857790	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of a novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- with no affinity to heparin in Gloydius tsushimaensis venom .
25653803	0	VEGF	159,163	vascular_endothelial_growth_factor	123,157	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Level|appos|START_ENTITY Level|compound|END_ENTITY	One Possible Mechanism of Pulsed Dye Laser Treatment on Infantile_Hemangioma : Induction of Endothelial Apoptosis and Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- Level Changes .
25845216	0	VEGF	124,128	vascular_endothelial_growth_factor	88,122	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	-LSB- Effects of electroacupuncture on learning-memory ability and expression of hippocampal vascular_endothelial_growth_factor -LRB- VEGF -RRB- , VEGF receptor 1 and 2 genes in vascular cognitive_impairment rats -RSB- .
25870249	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in prostate_cancer .
26588326	0	VEGF	51,55	vascular_endothelial_growth_factor	15,49	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on human orbital preadipocyte .
26617878	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- under hypoxia in placenta with intrahepatic_cholestasis_of_pregnancy and its clinically pathological significance .
26788968	0	VEGF	51,55	vascular_endothelial_growth_factor	15,49	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Coffee induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human neuroblastama SH-SY5Y cells .
7585655	0	VEGF	54,58	vascular_endothelial_growth_factor	18,52	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor gene , KDR , in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation .
7623107	0	VEGF	102,106	vascular_endothelial_growth_factor	66,100	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Development of retinal vasculature is mediated by hypoxia-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression by neuroglia .
8621443	0	VEGF	62,66	vascular_endothelial_growth_factor	26,60	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain .
8641698	0	VEGF	67,71	vascular_endothelial_growth_factor	26,60	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization of the human vascular_endothelial_growth_factor gene , VEGF , at chromosome 6p12 .
8958842	0	VEGF	71,75	vascular_endothelial_growth_factor	35,69	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization and expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the ovine corpus luteum .
8988772	0	VEGF	46,50	vascular_endothelial_growth_factor	10,44	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on survival of random extension of axial pattern skin flaps in the rat .
8994354	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in retinoblastoma but not in posterior uveal_melanoma .
9155049	0	VEGF	130,134	vascular_endothelial_growth_factor	94,128	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Neoangiogenesis and p53 protein_in_lung_cancer : their prognostic role and their relation with vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
9238051	0	VEGF	61,65	vascular_endothelial_growth_factor	25,59	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Conditional switching of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in tumors : induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal .
9386988	0	VEGF	49,53	vascular_endothelial_growth_factor	13,47	VEGF	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Detection of vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina .
9395496	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of VEGF165 .
9476086	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- during folliculogenesis and corpus luteum formation in the human ovary .
9647657	0	VEGF	79,83	vascular_endothelial_growth_factor	43,77	VEGF	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the endothelial cells of forming capillaries : an autocrine mechanism contributing to angiogenesis .
9674707	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression is mediated by internal initiation of translation and alternative initiation of transcription .
9711425	0	VEGF	70,74	vascular_endothelial_growth_factor	34,68	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Strongly enhanced serum levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- after polytrauma and burn .
9813373	0	VEGF	57,61	vascular_endothelial_growth_factor	21,55	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Hypoxic induction of vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in astroglial cultures .
9823983	0	VEGF	56,60	vascular_endothelial_growth_factor	20,54	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Predictive value of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in metastasis and prognosis of human colorectal_cancer .
9879835	0	VEGF	50,54	vascular_endothelial_growth_factor	14,48	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in various compartments of the human hair follicle .
9973154	0	VEGF	52,56	vascular_endothelial_growth_factor	16,50	VEGF	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Serum levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- are markedly elevated in patients with Wegener 's _ granulomatosis .
11162543	0	VEGF	0,4	vascular_permeability_factor	16,44	VEGF	vascular permeability factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	VEGF can act as vascular_permeability_factor in the hepatic sinusoids through upregulation of porosity of endothelial cells .
24316428	0	VEGF	42,46	vitamin_D_receptor	14,32	VEGF	vitamin D receptor	7422	7421	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|Activation Activation|nmod|END_ENTITY	Activation of vitamin_D_receptor promotes VEGF and CuZn-SOD expression in endothelial cells .
18632792	0	VEGF-164	59,67	VEGFR-2	83,90	VEGF-164	VEGFR-2	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|dep|END_ENTITY	Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors -LRB- VEGFR-2 , Npn-1 , and Npn-2 -RRB- in rats with cyclophosphamide-induced cystitis .
25586350	0	VEGF-A	21,27	Adiponectin	0,11	VEGF-A	Adiponectin	7422	9370	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Adiponectin inhibits VEGF-A in prostate_cancer cells .
15453096	0	VEGF-A	38,44	Ang1	8,12	VEGF-A	Ang1	7422	284	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Ang1 and its interaction with VEGF-A in astrocytomas .
18280482	0	VEGF-A	35,41	C-reactive_protein	0,18	VEGF-A	C-reactive protein	7422	1401	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK_1 / 2 signaling dependent pathway .
15532726	0	VEGF-A	27,33	ER-alpha	99,107	VEGF-A	ER-alpha	7422	2099	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Differential expression of VEGF-A mRNA by 17beta-estradiol in breast_tumor cells lacking classical ER-alpha may be mediated through a variant form of ER-alpha .
21455573	0	VEGF-A	0,6	ERK1/2	77,83	VEGF-A	ERK1/2	7422	5595;5594	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	VEGF-A not Ang2 mediates endothelial-like differentiation of immature DCs by ERK1/2 signaling in the microenvironment of human colon_adenocarcinoma .
25475856	0	VEGF-A	40,46	FcyRIIb	0,7	VEGF-A	FcyRIIb	7422	2213	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	FcyRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis .
16375885	0	VEGF-A	0,6	Flk-1	25,30	VEGF-A	Flk-1	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic_lung epithelial to endothelial crosstalk and branching morphogenesis .
20559689	0	VEGF-A	70,76	Flk-1	95,100	VEGF-A	Flk-1	403802(Tax:9615)	482154(Tax:9615)	Gene	Gene	receptor|amod|START_ENTITY study|nmod|receptor study|appos|END_ENTITY	Immunohistochemical study of the growth factors , aFGF , bFGF , PDGF-AB , VEGF-A and its receptor -LRB- Flk-1 -RRB- during arteriogenesis .
23698113	0	VEGF-A	28,34	Insulin	0,7	VEGF-A	Insulin	22339(Tax:10090)	3630	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Insulin directly stimulates VEGF-A production in the glomerular podocyte .
22836100	0	VEGF-A	62,68	Klotho	14,20	VEGF-A	Klotho	7422	9365	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Soluble serum Klotho in diabetic_nephropathy : relationship to VEGF-A .
22659470	0	VEGF-A	113,119	MMP-2	72,77	VEGF-A	MMP-2	7422	4313	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Highly invasive melanoma cells activate the vascular endothelium via an MMP-2 / integrin avb5-induced secretion of VEGF-A .
21062896	0	VEGF-A	18,24	MT1-MMP	0,7	VEGF-A	MT1-MMP	7422	4323	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src .
22670674	0	VEGF-A	31,37	MT1-MMP	0,7	VEGF-A	MT1-MMP	7422	4323	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	MT1-MMP modulates bFGF-induced VEGF-A expression in corneal fibroblasts .
26655500	0	VEGF-A	18,24	MULTIMERIN2	0,11	VEGF-A	MULTIMERIN2	7422	79812	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth .
22159356	0	VEGF-A	86,92	MicroRNA-205	0,12	VEGF-A	MicroRNA-205	7422	406988	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A .
26577912	0	VEGF-A	11,17	TGF-b1	45,51	VEGF-A	TGF-b1	7422	7040	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Peritoneal VEGF-A expression is regulated by TGF-b1 through an ID1 pathway in women with endometriosis .
16687456	0	VEGF-A	0,6	VEGF-C	35,41	VEGF-A	VEGF-C	7422	7424	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells .
21698469	0	VEGF-A	32,38	VEGF-C	0,6	VEGF-A	VEGF-C	7422	7424	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells ; promotes angiogenesis via RhoA mediated pathway .
26900960	0	VEGF-A	53,59	VEGF-C	0,6	VEGF-A	VEGF-C	7422	7424	Gene	Gene	Marker|acl|START_ENTITY Marker|nsubj|END_ENTITY	VEGF-C Is a Thyroid Marker of Malignancy Superior to VEGF-A in the Differential Diagnostics of Thyroid Lesions .
15132990	0	VEGF-A	0,6	VEGFR-2	72,79	VEGF-A	VEGFR-2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|formation formation|nmod|END_ENTITY	VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins .
25778658	0	VEGF-A	50,56	Vascular_Endothelial_Growth_Factor	14,48	VEGF-A	Vascular Endothelial Growth Factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF-A -RRB- in Rat Mandibular Salivary Gland during Paraneoplastic Process and Treatment with Cyclophosphamide and Melatonin .
9837777	0	VEGF-A	0,6	eNOS	29,33	VEGF-A	eNOS	7422	4846	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 -LRB- KDR -RRB- .
25244493	0	VEGF-A	125,131	matrix_metalloproteinase-9	81,107	VEGF-A	matrix metalloproteinase-9	7422	4318	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Targeting filamin_B induces tumor growth and metastasis via enhanced activity of matrix_metalloproteinase-9 and secretion of VEGF-A .
16312046	0	VEGF-A	120,126	vascular_endothelial_growth_factor-A	82,118	VEGF-A	vascular endothelial growth factor-A	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Effects of human breast stromal cells on conjugated linoleic_acid -LRB- CLA -RRB- modulated vascular_endothelial_growth_factor-A -LRB- VEGF-A -RRB- expression in MCF-7 cells .
18261732	0	VEGF-A	65,71	vascular_endothelial_growth_factor-A	27,63	VEGF-A	vascular endothelial growth factor-A	7422	7422	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	Prospective association of vascular_endothelial_growth_factor-A -LRB- VEGF-A -RRB- with coronary_heart_disease mortality in southeastern New England .
24138811	0	VEGF-A	94,100	vascular_endothelial_growth_factor_A	56,92	VEGF-A	vascular endothelial growth factor A	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The relationship between lymphatic vascular density and vascular_endothelial_growth_factor_A -LRB- VEGF-A -RRB- expression with clinical-pathological features and survival in pancreatic_adenocarcinomas .
14519669	0	VEGF-A_and_alphaVbeta3	0,22	N-Ras	72,77	VEGF-A and alphaVbeta3	N-Ras	7422	4893	Gene	Gene	angiogenesis|amod|START_ENTITY angiogenesis|nmod|END_ENTITY	VEGF-A_and_alphaVbeta3 integrin synergistically rescue angiogenesis via N-Ras and PI3-K signaling in human microvascular endothelial cells .
21169295	0	VEGF-B	93,99	RTEF-1	36,42	VEGF-B	RTEF-1	22340(Tax:10090)	21679(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	The endothelium-dependent effect of RTEF-1 in pressure overload cardiac_hypertrophy : role of VEGF-B .
20019242	0	VEGF-B	36,42	VEGFR-1	14,21	VEGF-B	VEGFR-1	89811(Tax:10116)	54251(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory_hypertrophy and preserves cardiac function after myocardial_infarction .
21666710	0	VEGF-C	19,25	C/EBP	0,5	VEGF-C	C/EBP	22341(Tax:10090)	12606(Tax:10090)	Gene	Gene	autocrine|nsubj|START_ENTITY END_ENTITY|parataxis|autocrine	C/EBP - regulates VEGF-C autocrine signaling in lymphangiogenesis and metastasis of lung_cancer through HIF-1a .
19280060	0	VEGF-C	27,33	COX-2	65,70	VEGF-C	COX-2	7424	5743	Gene	Gene	expression|amod|START_ENTITY significance|nmod|expression significance|nmod|END_ENTITY	Prognostic significance of VEGF-C expression in correlation with COX-2 , lymphatic microvessel density , and clinicopathologic characteristics in human non-small_cell_lung_cancer .
22169285	0	VEGF-C	28,34	CTGF	22,26	VEGF-C	CTGF	7424	1490	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
22169285	0	VEGF-C	28,34	CYR61	15,20	VEGF-C	CYR61	7424	3491	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
16080559	0	VEGF-C	53,59	HIF-1alpha	40,50	VEGF-C	HIF-1alpha	7424	3091	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of hypoxia-inducible factor -LRB- HIF-1alpha -RRB- , VEGF-C and VEGF-D in non-invasive and invasive breast ductal_carcinomas .
17219968	0	VEGF-C	24,30	HIF-1alpha	10,20	VEGF-C	HIF-1alpha	7424	3091	Gene	Gene	induced|compound|START_ENTITY END_ENTITY|nmod|induced	Effect of HIF-1alpha on VEGF-C induced lymphangiogenesis and lymph nodes metastases of pancreatic_cancer .
23158987	0	VEGF-C	24,30	HMGB1	11,16	VEGF-C	HMGB1	7424	3146	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of HMGB1 on the VEGF-C expression and proliferation of esophageal squamous cancer cells -RSB- .
26893739	0	VEGF-C	30,36	Heparanase	0,10	VEGF-C	Heparanase	7424	10855	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Heparanase regulates in vitro VEGF-C expression and its clinical significance to pancreatic_ductal_cell_adenocarcinoma .
16555123	0	VEGF-C	48,54	Hypoxia_inducible_factor-1alpha	0,31	VEGF-C	Hypoxia inducible factor-1alpha	7424	3091	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|END_ENTITY	Hypoxia_inducible_factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast_cancer .
21111670	0	VEGF-C	69,75	Id-1	10,14	VEGF-C	Id-1	7424	3397	Gene	Gene	down-regulation|nmod|START_ENTITY inhibits|nmod|down-regulation inhibits|nsubj|END_ENTITY	Silencing Id-1 inhibits lymphangiogenesis through down-regulation of VEGF-C in oral_squamous_cell_carcinoma .
25752543	0	VEGF-C	21,27	Neuropilin-2	39,51	VEGF-C	neuropilin-2	7424	8828	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form .
26081937	0	VEGF-C	106,112	Podoplanin	0,10	VEGF-C	Podoplanin	7424	10630	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Podoplanin is involved in the prognosis of head_and_neck_squamous_cell_carcinoma through interaction with VEGF-C .
16491267	0	VEGF-C	68,74	VEGF	61,65	VEGF-C	VEGF	7424	7422	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Increased expressions of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , VEGF-C and VEGF_receptor-3 in prostate_cancer tissue are associated with tumor progression .
16687456	0	VEGF-C	35,41	VEGF-A	0,6	VEGF-C	VEGF-A	7424	7422	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells .
21698469	0	VEGF-C	0,6	VEGF-A	32,38	VEGF-C	VEGF-A	7424	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells ; promotes angiogenesis via RhoA mediated pathway .
26900960	0	VEGF-C	0,6	VEGF-A	53,59	VEGF-C	VEGF-A	7424	7422	Gene	Gene	Marker|nsubj|START_ENTITY Marker|acl|END_ENTITY	VEGF-C Is a Thyroid Marker of Malignancy Superior to VEGF-A in the Differential Diagnostics of Thyroid Lesions .
18074680	0	VEGF-C	16,22	VEGF-D	24,30	VEGF-C	VEGF-D	7424	2277	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nsubj|levels	Serum levels of VEGF-C , VEGF-D , and sVEGF-R2 in patients with lung_cancer during chemotherapy .
11332691	0	VEGF-C	14,20	VEGFR-2	53,60	VEGF-C	VEGFR-2	7424	3791	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|receptors receptors|amod|END_ENTITY	Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast .
21680174	0	VEGF-C	27,33	VEGFR-2	133,140	VEGF-C	VEGFR-2	7424	3791	Gene	Gene	silencing|nmod|START_ENTITY inhibits|nsubj|silencing inhibits|advcl|down-regulating down-regulating|dobj|pathways pathways|compound|END_ENTITY	RNAi-mediated silencing of VEGF-C inhibits non-small cell lung_cancer progression by simultaneously down-regulating the CXCR4 , CCR7 , VEGFR-2 and VEGFR-3-dependent axes-induced ERK , p38 and AKT signalling pathways .
22169285	0	VEGF-C	28,34	VEGFR-2	36,43	VEGF-C	VEGFR-2	7424	3791	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
26798047	0	VEGF-C	23,29	VEGFR-2	49,56	VEGF-C	VEGFR-2	7424	3791	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Elevated Expression of VEGF-C and Its Receptors , VEGFR-2 and VEGFR-3 , in Patients with Mesial Temporal_Lobe_Epilepsy .
8617204	0	VEGF-C	44,50	VEGFR-2	96,103	VEGF-C	VEGFR-2	7424	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY kinases|nsubj|vascular_endothelial_growth_factor kinases|amod|ligand ligand|nmod|Flt4 Flt4|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
11023993	0	VEGF-C	0,6	VEGFR-3	73,80	VEGF-C	VEGFR-3	7424	2324	Gene	Gene	expression|nsubj|START_ENTITY expression|advmod|END_ENTITY	VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor , VEGFR-3 , in fenestrated blood vessels in human tissues .
11683876	0	VEGF-C	61,67	VEGFR-3	102,109	VEGF-C	VEGFR-3	114111(Tax:10116)	114110(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Characterization of indolinones which preferentially inhibit VEGF-C - and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2 .
15150322	0	VEGF-C	165,171	VEGFR-3	97,104	VEGF-C	VEGFR-3	7424	2324	Gene	Gene	antagonizes|nmod|START_ENTITY antibody|acl:relcl|antagonizes antibody|compound|END_ENTITY	Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C .
19005491	0	VEGF-C	37,43	VEGFR-3	18,25	VEGF-C	VEGFR-3	22341(Tax:10090)	14257(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin_inflammation by promoting lymphangiogenesis .
25473093	0	VEGF-C	52,58	VEGFR-3	78,85	VEGF-C	VEGFR-3	7424	2324	Gene	Gene	Vascular_Endothelial_Growth_Factor-C|appos|START_ENTITY Vascular_Endothelial_Growth_Factor-C|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor-C -LRB- VEGF-C -RRB- and Its Receptor -LRB- VEGFR-3 -RRB- in the Glial Reaction Elicited by Human Mesenchymal Stem Cell Engraftment in the Normal Rat Brain .
8617204	0	VEGF-C	44,50	VEGFR-3	78,85	VEGF-C	VEGFR-3	7424	2324	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY kinases|nsubj|vascular_endothelial_growth_factor kinases|amod|ligand ligand|nmod|Flt4 Flt4|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
26216169	0	VEGF-C	38,44	Vascular_endothelial_growth_factor_C	0,36	VEGF-C	Vascular endothelial growth factor C	7424	7424	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor_C -LRB- VEGF-C -RRB- expression predicts metastasis in tongue_cancer .
22496919	0	VEGF-C	44,50	extra_domain_A	4,18	VEGF-C	extra domain A	7424	1896	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	The extra_domain_A of fibronectin increases VEGF-C expression in colorectal_carcinoma involving the PI3K/AKT signaling pathway .
23242251	0	VEGF-C	37,43	histone_deacetylase	77,96	VEGF-C	histone deacetylase	7424	9734	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Inhibition of lymphangiogenic factor VEGF-C expression and production by the histone_deacetylase inhibitor suberoylanilide_hydroxamic_acid in breast_cancer cells .
11437102	0	VEGF-C	63,69	vascular_endothelial_growth_factor-C	25,61	VEGF-C	vascular endothelial growth factor-C	7424	7424	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- in breast_cancer .
14613645	0	VEGF-C	70,76	vascular_endothelial_growth_factor-C	32,68	VEGF-C	vascular endothelial growth factor-C	7424	7424	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	-LSB- Significance and expression of vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- in esophageal_squamous_carcinoma and glioma -RSB- .
18383841	0	VEGF-C	57,63	vascular_endothelial_growth_factor-C	19,55	VEGF-C	vascular endothelial growth factor-C	7424	7424	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Preoperative serum vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- levels predict recurrence in patients with esophageal_cancer .
21880798	0	VEGF-D	73,79	Neuropilin-2	0,12	VEGF-D	Neuropilin-2	2277	8828	Gene	Gene	expression|amod|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|amod|END_ENTITY	Neuropilin-2 expression in papillary_thyroid_carcinoma : correlation with VEGF-D expression , lymph_node_metastasis , and VEGF-D-induced aggressive cancer cell phenotype .
18074680	0	VEGF-D	24,30	VEGF-C	16,22	VEGF-D	VEGF-C	2277	7424	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|END_ENTITY	Serum levels of VEGF-C , VEGF-D , and sVEGF-R2 in patients with lung_cancer during chemotherapy .
17951197	0	VEGF-D	0,6	VEGFR-3	27,34	VEGF-D	VEGFR-3	2277	2324	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast_cancer .
17929249	0	VEGF-D	18,24	interleukin-1beta	39,56	VEGF-D	interleukin-1beta	360457(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Downregulation of VEGF-D expression by interleukin-1beta in cardiac microvascular endothelial cells is mediated by MAPKs and PKCalpha/beta1 .
17404025	0	VEGF-D	46,52	vascular_endothelial_growth_factor-D	8,44	VEGF-D	vascular endothelial growth factor-D	360457(Tax:10116)	360457(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of vascular_endothelial_growth_factor-D -LRB- VEGF-D -RRB- on IL-6 expression in cerulein-stimulated pancreatic acinar cells .
16794222	0	VEGF-E	9,15	VEGFR-2	52,59	VEGF-E	VEGFR-2	54635(Tax:10090)	16542(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|angiogenesis angiogenesis|nmod|END_ENTITY	Chimeric VEGF-E -LRB- NZ7 -RRB- / PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation .
12551914	0	VEGF-ENZ-7	104,114	VEGFR-2	151,158	VEGF-ENZ-7	VEGFR-2	7422	3791	Gene	Gene	set|appos|START_ENTITY essential|nsubj|set essential|nmod|activation activation|nmod|signaling signaling|compound|END_ENTITY	A set of loop-1 and -3 structures in the novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- family member , VEGF-ENZ-7 , is essential for the activation of VEGFR-2 signaling .
17873319	0	VEGF-R	139,145	EGF-R	83,88	VEGF-R	EGF-R	3791	1956	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY epidermal_growth_factor_receptor|appos|END_ENTITY	Differential effects of cetuximab and AEE_788 on epidermal_growth_factor_receptor -LRB- EGF-R -RRB- and vascular_endothelial_growth_factor_receptor -LRB- VEGF-R -RRB- in thyroid_cancer cell lines .
15492987	0	VEGF-R1	75,82	Flt-1	84,89	VEGF-R1	Flt-1	2321	2321	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
15492987	0	VEGF-R1	75,82	VEGF	50,54	VEGF-R1	VEGF	2321	7422	Gene	Gene	-RSB-|compound|START_ENTITY vascular_endothelial_growth_factor|dep|-RSB- vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
26783205	0	VEGF-R1	56,63	p53	79,82	VEGF-R1	p53	2321	7157	Gene	Gene	START_ENTITY|nmod|status status|compound|END_ENTITY	The relationship of the angiogenesis regulators VEGF-A , VEGF-R1 and VEGF-R2 to p53 status and prognostic factors in epithelial_ovarian_carcinoma in FIGO-stages I-II .
15492987	0	VEGF-R1	75,82	vascular_endothelial_growth_factor	14,48	VEGF-R1	vascular endothelial growth factor	2321	7422	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|dep|-RSB-	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
10893303	0	VEGF-R2	144,151	Flk-1	153,158	VEGF-R2	Flk-1	3791	3791	Gene	Gene	START_ENTITY|appos|KDR KDR|compound|END_ENTITY	Identification of substituted 3 - -LSB- -LRB- 4,5,6 , _ 7-tetrahydro-1H-indol-2-yl -RRB- methylene -RSB- -1,3 - dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 -LRB- Flk-1 / KDR -RRB- , FGF-R1 , and PDGF-Rbeta tyrosine kinases .
21115896	0	VEGF-R2	23,30	bFGF-R	31,37	VEGF-R2	bFGF-R	3791	2260	Gene	Gene	/|nsubj|START_ENTITY /|dobj|inhibitor inhibitor|amod|END_ENTITY	Brivanib , a novel dual VEGF-R2 / bFGF-R inhibitor .
19825968	0	VEGF-R3	116,123	COX-2	84,89	VEGF-R3	COX-2	2324	5743	Gene	Gene	pathway|compound|START_ENTITY cells|nmod|pathway END_ENTITY|nmod|cells	Vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3 / JNK/AP -1 pathway .
22903062	0	VEGFA	73,78	E2F7	0,4	VEGFA	E2F7	30682(Tax:7955)	567941(Tax:7955)	Gene	Gene	activation|nmod|START_ENTITY promote|nmod|activation promote|nsubj|END_ENTITY	E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1 .
24611881	0	VEGFA	28,33	HIF-1a	21,27	VEGFA	HIF-1a	7422	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Sorafenib blocks the HIF-1a / VEGFA pathway , inhibits tumor invasion , and induces apoptosis in hepatoma cells .
25860916	0	VEGFA	50,55	HSP70	28,33	VEGFA	HSP70	22339(Tax:10090)	15511(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol promotes angiogenesis in a mouse model .
26243699	0	VEGFA	50,55	HSP70	28,33	VEGFA	HSP70	22339(Tax:10090)	15511(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
26243699	0	VEGFA	50,55	HSP70	28,33	VEGFA	HSP70	22339(Tax:10090)	15511(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	Mesenchymal stem cell-based HSP70 promoter-driven VEGFA induction by resveratrol alleviates elastase-induced emphysema in a mouse model .
26336827	0	VEGFA	89,94	MiR-497	0,7	VEGFA	MiR-497	22339(Tax:10090)	751537(Tax:10090)	Gene	Gene	inhibiting|dobj|START_ENTITY suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	MiR-497 suppresses angiogenesis and metastasis of hepatocellular_carcinoma by inhibiting VEGFA and AEG-1 .
18317782	0	VEGFA	63,68	VEGFB	77,82	VEGFA	VEGFB	7422	7423	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Cellular distribution of vascular_endothelial_growth_factor A -LRB- VEGFA -RRB- and B -LRB- VEGFB -RRB- and VEGF receptors 1 and 2 in focal cortical_dysplasia_type_IIB .
19875757	0	VEGFA	58,63	VEGFR2	84,90	VEGFA	VEGFR2	7422	3791	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Clinical relevance of vascular_endothelial_growth_factor -LRB- VEGFA -RRB- and VEGF receptor -LRB- VEGFR2 -RRB- gene polymorphism on the treatment outcome following imatinib therapy .
26476544	0	VEGFA	53,58	VEGFR2	78,84	VEGFA	VEGFR2	7422	3791	Gene	Gene	Vascular_Endothelial_Growth_Factor_A|appos|START_ENTITY Vascular_Endothelial_Growth_Factor_A|appos|END_ENTITY	Association of Vascular_Endothelial_Growth_Factor_A -LRB- VEGFA -RRB- and its Receptor -LRB- VEGFR2 -RRB- Gene Polymorphisms with Risk of Chronic_Myeloid_Leukemia and Influence on Clinical Outcome .
22231433	0	VEGFA	43,48	Vascular_endothelial_growth_factor_A	0,36	VEGFA	Vascular endothelial growth factor A	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Vascular_endothelial_growth_factor_A gene -LRB- VEGFA -RRB- polymorphisms and expression of VEGFA gene in lung_cancer patients of Kashmir Valley -LRB- India -RRB- .
27015364	0	VEGFA	70,75	miR-497	62,69	VEGFA	miR-497	7422	574456	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Twist promotes angiogenesis in pancreatic_cancer by targeting miR-497 / VEGFA axis .
19700204	0	VEGFA	97,102	vascular_endothelial_growth_factor	61,95	VEGFA	vascular endothelial growth factor	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Haplotype analysis of single nucleotide polymorphisms in the vascular_endothelial_growth_factor -LRB- VEGFA -RRB- gene and antidepressant treatment response in major depressive_disorder .
22429695	0	VEGFA	58,63	vascular_endothelial_growth_factor_A	20,56	VEGFA	vascular endothelial growth factor A	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Polymorphism in the vascular_endothelial_growth_factor_A -LRB- VEGFA -RRB- gene is associated with serum VEGF-A level and disease activity in rheumatoid_arthritis : differential effect of cigarette smoking .
22776467	0	VEGFA	113,118	vascular_endothelial_growth_factor_A	76,112	VEGFA	vascular endothelial growth factor A	7422	7422	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Age at onset of rheumatoid_arthritis : association with polymorphisms in the vascular_endothelial_growth_factor_A -LRB- VEGFA -RRB- gene and an intergenic locus between matrix_metalloproteinase _ -LRB- MMP -RRB- _ 1_and_3 genes .
18317782	0	VEGFB	77,82	VEGFA	63,68	VEGFB	VEGFA	7423	7422	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Cellular distribution of vascular_endothelial_growth_factor A -LRB- VEGFA -RRB- and B -LRB- VEGFB -RRB- and VEGF receptors 1 and 2 in focal cortical_dysplasia_type_IIB .
24744435	0	VEGFC	72,77	vascular_endothelial_growth_factor-C	29,65	VEGFC	vascular endothelial growth factor-C	7424	7424	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel stop mutation in the vascular_endothelial_growth_factor-C gene -LRB- VEGFC -RRB- results in Milroy-like_disease .
25676691	0	VEGFR	0,5	CXCR4	28,33	VEGFR	CXCR4	3791	7852	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|dobj|END_ENTITY	VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFbR signaling-dependent manner .
12509223	0	VEGFR	54,59	VEGF	82,86	VEGFR	VEGF	3791	7422	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|stimulation stimulation|compound|END_ENTITY	Src kinase becomes preferentially associated with the VEGFR , KDR/Flk -1 , following VEGF stimulation of vascular endothelial cells .
14714966	0	VEGFR	135,140	VEGF	110,114	VEGFR	VEGF	3791	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Dermatomyositis with peripheral nervous system involvement : activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and VEGF_receptor -LRB- VEGFR -RRB- in vasculitic_lesions .
17098419	0	VEGFR	124,129	VEGF	69,73	VEGFR	VEGF	3791	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	The clinical toxicity profile of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and vascular_endothelial_growth_factor receptor -LRB- VEGFR -RRB- targeting angiogenesis inhibitors ; a review .
25676691	0	VEGFR	0,5	VEGF	37,41	VEGFR	VEGF	3791	7422	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|nmod|glioblastoma glioblastoma|amod|END_ENTITY	VEGFR inhibitors upregulate CXCR4 in VEGF receptor-expressing glioblastoma in a TGFbR signaling-dependent manner .
22038228	0	VEGFR	126,131	vascular_endothelial_growth_factor	81,115	VEGFR	vascular endothelial growth factor	3791	7422	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Nephrotic_syndrome unfavorable course correlates with downregulation of podocyte vascular_endothelial_growth_factor receptor -LRB- VEGFR -RRB- -2 .
27059553	0	VEGFR	77,82	vascular_endothelial_growth_factor	32,66	VEGFR	vascular endothelial growth factor	3791	7422	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Safety and clinical activity of vascular_endothelial_growth_factor receptor -LRB- VEGFR -RRB- - tyrosine kinase inhibitors after programmed cell death 1 inhibitor treatment in patients with metastatic clear_cell_renal_cell_carcinoma .
21719570	0	VEGFR	72,77	vascular_endothelial_growth_factor_receptor	27,70	VEGFR	vascular endothelial growth factor receptor	3791	3791	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Vitreous levels of soluble vascular_endothelial_growth_factor_receptor -LRB- VEGFR -RRB- -1 in eyes with vitreoretinal_diseases .
16249383	0	VEGFR-1	0,7	FLT-1	9,14	VEGFR-1	FLT-1	2321	2321	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	VEGFR-1 -LRB- FLT-1 -RRB- activation modulates acute_lymphoblastic_leukemia localization and survival within the bone marrow , determining the onset of extramedullary disease .
19276374	0	VEGFR-1	81,88	FLT1	89,93	VEGFR-1	FLT1	2321	2321	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1 / FLT1 in leukemic_cancer cells .
15111299	0	VEGFR-1	62,69	Flk-1	81,86	VEGFR-1	Flk-1	14254(Tax:10090)	16542(Tax:10090)	Gene	Gene	Flt-1|appos|START_ENTITY modulates|nsubj|Flt-1 modulates|dobj|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
21441409	0	VEGFR-1	84,91	PDGFR	132,137	VEGFR-1	PDGFR	14254(Tax:10090)	18596(Tax:10090)	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	Assessing the activity of cediranib , a VEGFR-2 / 3 tyrosine kinase inhibitor , against VEGFR-1 and members of the structurally related PDGFR family .
12850696	0	VEGFR-1	52,59	VEGF	66,70	VEGFR-1	VEGF	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	ERK/MAPK-dependent PI3K/Akt phosphorylation through VEGFR-1 after VEGF stimulation in activated hepatic stellate cells .
20019242	0	VEGFR-1	14,21	VEGF-B	36,42	VEGFR-1	VEGF-B	54251(Tax:10116)	89811(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory_hypertrophy and preserves cardiac function after myocardial_infarction .
15111299	0	VEGFR-1	62,69	VEGFR-2	88,95	VEGFR-1	VEGFR-2	14254(Tax:10090)	16542(Tax:10090)	Gene	Gene	Flt-1|appos|START_ENTITY modulates|nsubj|Flt-1 modulates|dobj|Flk-1 Flk-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
16979123	0	VEGFR-1	92,99	VEGFR-2	79,86	VEGFR-1	VEGFR-2	2321	3791	Gene	Gene	angiogenesis|amod|START_ENTITY angiogenesis|nmod|END_ENTITY	Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2 , not VEGFR-1 .
19020728	0	VEGFR-1	79,86	VEGFR-2	66,73	VEGFR-1	VEGFR-2	2321	3791	Gene	Gene	angiogenesis|amod|START_ENTITY angiogenesis|nmod|END_ENTITY	Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2 , not VEGFR-1 .
12670505	0	VEGFR-1	96,103	Vascular_endothelial_growth_factor	0,34	VEGFR-1	Vascular endothelial growth factor	2321	7422	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor upregulates pigment_epithelium-derived_factor expression via VEGFR-1 in human retinal pigment epithelial cells .
12670505	0	VEGFR-1	96,103	pigment_epithelium-derived_factor	47,80	VEGFR-1	pigment epithelium-derived factor	2321	57104	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor upregulates pigment_epithelium-derived_factor expression via VEGFR-1 in human retinal pigment epithelial cells .
20615131	0	VEGFR-1	78,85	vascular_endothelial_growth_factor	24,58	VEGFR-1	vascular endothelial growth factor	2321	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of vascular_endothelial_growth_factor and its receptors , VEGFR-1 and VEGFR-2 , in medullary_thyroid_carcinoma .
17036392	0	VEGFR-1_and_2	67,80	vascular_endothelial_growth_factor	14,48	VEGFR-1 and 2	vascular endothelial growth factor	2321;3791	7422	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptors VEGFR-1_and_2 in gastrointestinal_stromal_tumors , leiomyomas and schwannomas .
17588480	0	VEGFR-2	17,24	AC133	11,16	VEGFR-2	AC133	3791	8842	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD34 + AC133 + VEGFR-2 + cells are not endothelial progenitor cells but distinct , primitive hematopoietic progenitors .
16439688	0	VEGFR-2	13,20	CD133	6,11	VEGFR-2	CD133	3791	8842	Gene	Gene	progenitor|compound|START_ENTITY +|dep|progenitor +|compound|END_ENTITY	CD34 - / CD133 + / VEGFR-2 + endothelial progenitor cell subpopulation with potent vasoregenerative capacities .
19995856	0	VEGFR-2	16,23	CD133	25,30	VEGFR-2	CD133	3791	8842	Gene	Gene	+|compound|START_ENTITY Accumulation|nmod|+ VEGFR-2|nsubj|Accumulation VEGFR-2|parataxis|+ +|nsubj|END_ENTITY	Accumulation of VEGFR-2 + / CD133 + cells and decreased number and impaired functionality of CD34 + / VEGFR-2 + cells in patients with SLE .
19995856	0	VEGFR-2	95,102	CD133	25,30	VEGFR-2	CD133	3791	8842	Gene	Gene	START_ENTITY|parataxis|+ +|nsubj|END_ENTITY	Accumulation of VEGFR-2 + / CD133 + cells and decreased number and impaired functionality of CD34 + / VEGFR-2 + cells in patients with SLE .
20360595	0	VEGFR-2	45,52	CD133	39,44	VEGFR-2	CD133	3791	8842	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Maternal circulating CD34 + VEGFR-2 + and CD133 + VEGFR-2 + progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia .
22480576	0	VEGFR-2	45,52	CD133	34,39	VEGFR-2	CD133	3791	8842	Gene	Gene	CD45|compound|START_ENTITY CD45|compound|END_ENTITY	Isolation and characterization of CD133 + CD34 + VEGFR-2 + CD45 - fetal endothelial cells from human term placenta .
10648408	0	VEGFR-2	14,21	CD34	53,57	VEGFR-2	CD34	3791	947	Gene	Gene	Expression|nmod|START_ENTITY Expression|advcl|circulating circulating|dobj|END_ENTITY	Expression of VEGFR-2 and AC133 by circulating human CD34 -LRB- + -RRB- cells identifies a population of functional endothelial precursors .
16439688	0	VEGFR-2	13,20	CD34	0,4	VEGFR-2	CD34	3791	947	Gene	Gene	progenitor|compound|START_ENTITY +|dep|progenitor END_ENTITY|parataxis|+	CD34 - / CD133 + / VEGFR-2 + endothelial progenitor cell subpopulation with potent vasoregenerative capacities .
17588480	0	VEGFR-2	17,24	CD34	6,10	VEGFR-2	CD34	3791	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Human CD34 + AC133 + VEGFR-2 + cells are not endothelial progenitor cells but distinct , primitive hematopoietic progenitors .
18791450	0	VEGFR-2	57,64	CD34	51,55	VEGFR-2	CD34	3791	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Novel antibodies to the donor stem cell population CD34 + / VEGFR-2 + are associated with rejection after hematopoietic stem cell transplantation .
20360595	0	VEGFR-2	26,33	CD34	21,25	VEGFR-2	CD34	3791	947	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Maternal circulating CD34 + VEGFR-2 + and CD133 + VEGFR-2 + progenitor cells increase during normal pregnancy but are reduced in women with preeclampsia .
22480576	0	VEGFR-2	45,52	CD34	40,44	VEGFR-2	CD34	3791	947	Gene	Gene	CD45|compound|START_ENTITY CD45|compound|END_ENTITY	Isolation and characterization of CD133 + CD34 + VEGFR-2 + CD45 - fetal endothelial cells from human term placenta .
22169285	0	VEGFR-2	36,43	CTGF	22,26	VEGFR-2	CTGF	3791	1490	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
22169285	0	VEGFR-2	36,43	CYR61	15,20	VEGFR-2	CYR61	3791	3491	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
25523287	0	VEGFR-2	87,94	FLT-3	95,100	VEGFR-2	FLT-3	3791	2322	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888 , a VEGFR-2 / FLT-3 kinase inhibitor .
18223683	0	VEGFR-2	54,61	Galectin-1	0,10	VEGFR-2	Galectin-1	3791	3956	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Galectin-1 , a novel ligand of neuropilin-1 , activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells .
12453432	0	VEGFR-2	136,143	KDR	144,147	VEGFR-2	KDR	16542(Tax:10090)	16542(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2 / KDR expression .
25523287	0	VEGFR-2	87,94	MK-0888	76,83	VEGFR-2	MK-0888	3791	1476989(Tax:190192)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888 , a VEGFR-2 / FLT-3 kinase inhibitor .
16621967	0	VEGFR-2	28,35	Neuropilin-2	0,12	VEGFR-2	Neuropilin-2	3791	8828	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration .
17194893	0	VEGFR-2	48,55	PlGF	19,23	VEGFR-2	PlGF	3791	5228	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Chimeric VEGF-ENZ7 / PlGF specifically binding to VEGFR-2 accelerates skin wound healing via enhancement of neovascularization .
11967019	0	VEGFR-2	49,56	VEGF	76,80	VEGFR-2	VEGF	3791	7422	Gene	Gene	START_ENTITY|advcl|increasing increasing|dobj|expression expression|amod|END_ENTITY	Renal_ischemia-reperfusion increases endothelial VEGFR-2 without increasing VEGF or VEGFR-1 expression .
12094254	0	VEGFR-2	91,98	VEGF	54,58	VEGFR-2	VEGF	3791	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Overexpression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its cellular receptor KDR -LRB- VEGFR-2 -RRB- in the bone marrow of patients with acute_myeloid_leukemia .
12205052	0	VEGFR-2	53,60	VEGF	99,103	VEGFR-2	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY vivo|nmod|pathway angiogenesis|nmod|vivo promotes|dobj|angiogenesis promotes|advcl|inducing inducing|dobj|synthesis synthesis|compound|END_ENTITY	Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion .
12551914	0	VEGFR-2	151,158	VEGF	83,87	VEGFR-2	VEGF	3791	7422	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling essential|nmod|activation essential|nsubj|set set|appos|END_ENTITY	A set of loop-1 and -3 structures in the novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- family member , VEGF-ENZ-7 , is essential for the activation of VEGFR-2 signaling .
14626450	0	VEGFR-2	110,117	VEGF	164,168	VEGFR-2	VEGF	3791	7422	Gene	Gene	role|nmod|START_ENTITY identifies|dobj|role identifies|nmod|responses responses|nmod|END_ENTITY	Selective inhibition of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF .
14626450	0	VEGFR-2	71,78	VEGF	164,168	VEGFR-2	VEGF	3791	7422	Gene	Gene	vascular_endothelial_growth_factor_receptor-2|appos|START_ENTITY inhibition|nmod|vascular_endothelial_growth_factor_receptor-2 identifies|nsubj|inhibition identifies|nmod|responses responses|nmod|END_ENTITY	Selective inhibition of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF .
15111299	0	VEGFR-2	88,95	VEGF	40,44	VEGFR-2	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	Flk-1|appos|START_ENTITY modulates|dobj|Flk-1 modulates|nsubj|Flt-1 Flt-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
16914140	0	VEGFR-2	110,117	VEGF	186,190	VEGFR-2	VEGF	3791	7422	Gene	Gene	II|appos|START_ENTITY formation|nmod|II formation|dep|mechanism mechanism|nmod|END_ENTITY	Complex formation between tissue_transglutaminase II -LRB- tTG -RRB- and vascular_endothelial_growth_factor_receptor_2 -LRB- VEGFR-2 -RRB- : proposed mechanism for modulation of endothelial cell response to VEGF .
16930552	0	VEGFR-2	14,21	VEGF	53,57	VEGFR-2	VEGF	3791	7422	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of VEGFR-2 on HaCaT cells is regulated by VEGF and plays an active role in mediating VEGF induced effects .
16966330	0	VEGFR-2	34,41	VEGF	174,178	VEGFR-2	VEGF	3791	7422	Gene	Gene	Tyr1214|nmod|START_ENTITY Phosphorylation|nmod|Tyr1214 triggers|nsubj|Phosphorylation triggers|dobj|recruitment recruitment|nmod|Fyn Fyn|acl|leading leading|nmod|END_ENTITY	Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF .
17024605	0	VEGFR-2	88,95	VEGF	66,70	VEGFR-2	VEGF	3791	7422	Gene	Gene	angiogenesis|amod|START_ENTITY angiogenesis|nmod|END_ENTITY	Wogonin inhibits IL-6-induced angiogenesis via down-regulation of VEGF and VEGFR-1 , not VEGFR-2 .
17512973	0	VEGFR-2	101,108	VEGF	0,4	VEGFR-2	VEGF	3791	7422	Gene	Gene	activator|compound|START_ENTITY involvement|nmod|activator activity|dep|involvement increases|dobj|activity increases|nsubj|END_ENTITY	VEGF increases the fibrinolytic activity of endothelial cells within fibrin matrices : involvement of VEGFR-2 , tissue type plasminogen activator and matrix metalloproteinases .
19540581	0	VEGFR-2	70,77	VEGF	151,155	VEGFR-2	VEGF	3791	7422	Gene	Gene	phosphorylation|appos|START_ENTITY immobilized|nsubj|phosphorylation immobilized|dobj|END_ENTITY	The phosphorylation of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- by engineered surfaces with electrostatically or covalently immobilized VEGF .
20961309	0	VEGFR-2	8,15	VEGF	51,55	VEGFR-2	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|dep|variant variant|nmod|receptors receptors|compound|END_ENTITY	Soluble VEGFR-2 : an antilymphangiogenic variant of VEGF receptors .
21826315	0	VEGFR-2	41,48	VEGF	0,4	VEGFR-2	VEGF	3791	7422	Gene	Gene	phosphorylation|compound|START_ENTITY required|nmod|phosphorylation required|nsubjpass|internalization internalization|compound|END_ENTITY	VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF .
21826315	0	VEGFR-2	41,48	VEGF	114,118	VEGFR-2	VEGF	3791	7422	Gene	Gene	phosphorylation|compound|START_ENTITY required|nmod|phosphorylation required|nmod|END_ENTITY	VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF .
21849059	0	VEGFR-2	117,124	VEGF	16,20	VEGFR-2	VEGF	3791	7422	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Cytotoxicity Cytotoxicity|nmod|END_ENTITY	Cytotoxicity of VEGF -LRB- 121 -RRB- / rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2 .
25151964	0	VEGFR-2	49,56	VEGF	0,4	VEGFR-2	VEGF	3791	7422	Gene	Gene	Stat3|compound|START_ENTITY drives|nmod|Stat3 drives|nsubj|END_ENTITY	VEGF drives cancer-initiating stem cells through VEGFR-2 / Stat3 signaling to upregulate Myc and Sox2 .
25546248	0	VEGFR-2	21,28	VEGF	121,125	VEGFR-2	VEGF	3791	7422	Gene	Gene	activation|compound|START_ENTITY activation|nmod|tight tight|nmod|gallate gallate|nmod|END_ENTITY	Potent inhibition of VEGFR-2 activation by tight binding of green tea epigallocatechin gallate and apple procyanidins to VEGF : Relevance to angiogenesis .
25825981	0	VEGFR-2	39,46	VEGF	75,79	VEGFR-2	VEGF	3791	7422	Gene	Gene	START_ENTITY|acl|mediating mediating|nmod|END_ENTITY	EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF .
26154255	0	VEGFR-2	93,100	VEGF	87,91	VEGFR-2	VEGF	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY Vascular_Endothelial_Growth_Factor|dep|Signaling Vascular_Endothelial_Growth_Factor|appos|END_ENTITY	Geraniol Suppresses Angiogenesis by Downregulating Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- / VEGFR-2 Signaling .
26777435	0	VEGFR-2	48,55	VEGF	0,4	VEGFR-2	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	VEGF released from a fibrin biomatrix increases VEGFR-2 expression and improves early outcome after ischaemia-reperfusion injury .
18632792	0	VEGFR-2	83,90	VEGF-164	59,67	VEGFR-2	VEGF-164	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	Upregulation|dep|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors -LRB- VEGFR-2 , Npn-1 , and Npn-2 -RRB- in rats with cyclophosphamide-induced cystitis .
15132990	0	VEGFR-2	72,79	VEGF-A	0,6	VEGFR-2	VEGF-A	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	formation|nmod|START_ENTITY promotes|dobj|formation promotes|nsubj|END_ENTITY	VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins .
11332691	0	VEGFR-2	53,60	VEGF-C	14,20	VEGFR-2	VEGF-C	3791	7424	Gene	Gene	receptors|amod|START_ENTITY Expression|nmod|receptors Expression|nmod|END_ENTITY	Expression of VEGF-C and activation of its receptors VEGFR-2 and VEGFR-3 in trophoblast .
22169285	0	VEGFR-2	36,43	VEGF-C	28,34	VEGFR-2	VEGF-C	3791	7424	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Expression of CYR61 , CTGF , VEGF-C , VEGFR-2 mRNA in bone marrow of leukemia patients and its clinical significance -RSB- .
26798047	0	VEGFR-2	49,56	VEGF-C	23,29	VEGFR-2	VEGF-C	3791	7424	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Elevated Expression of VEGF-C and Its Receptors , VEGFR-2 and VEGFR-3 , in Patients with Mesial Temporal_Lobe_Epilepsy .
8617204	0	VEGFR-2	96,103	VEGF-C	44,50	VEGFR-2	VEGF-C	3791	7424	Gene	Gene	Flt4|appos|START_ENTITY ligand|nmod|Flt4 kinases|amod|ligand kinases|nsubj|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
16794222	0	VEGFR-2	52,59	VEGF-E	9,15	VEGFR-2	VEGF-E	16542(Tax:10090)	54635(Tax:10090)	Gene	Gene	angiogenesis|nmod|START_ENTITY promotes|dobj|angiogenesis promotes|nsubj|END_ENTITY	Chimeric VEGF-E -LRB- NZ7 -RRB- / PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation .
12551914	0	VEGFR-2	151,158	VEGF-ENZ-7	104,114	VEGFR-2	VEGF-ENZ-7	3791	7422	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling essential|nmod|activation essential|nsubj|set set|appos|END_ENTITY	A set of loop-1 and -3 structures in the novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- family member , VEGF-ENZ-7 , is essential for the activation of VEGFR-2 signaling .
15111299	0	VEGFR-2	88,95	VEGFR-1	62,69	VEGFR-2	VEGFR-1	16542(Tax:10090)	14254(Tax:10090)	Gene	Gene	Flk-1|appos|START_ENTITY modulates|dobj|Flk-1 modulates|nsubj|Flt-1 Flt-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
16979123	0	VEGFR-2	79,86	VEGFR-1	92,99	VEGFR-2	VEGFR-1	3791	2321	Gene	Gene	angiogenesis|nmod|START_ENTITY angiogenesis|amod|END_ENTITY	Protective role of wogonin against lipopolysaccharide-induced angiogenesis via VEGFR-2 , not VEGFR-1 .
19020728	0	VEGFR-2	66,73	VEGFR-1	79,86	VEGFR-2	VEGFR-1	3791	2321	Gene	Gene	angiogenesis|nmod|START_ENTITY angiogenesis|amod|END_ENTITY	Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2 , not VEGFR-1 .
26154255	0	VEGFR-2	93,100	Vascular_Endothelial_Growth_Factor	51,85	VEGFR-2	Vascular Endothelial Growth Factor	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|dep|Signaling	Geraniol Suppresses Angiogenesis by Downregulating Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- / VEGFR-2 Signaling .
20606037	0	VEGFR-2	45,52	Vascular_endothelial_growth_factor	0,34	VEGFR-2	Vascular endothelial growth factor	3791	7422	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Vascular_endothelial_growth_factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers .
26107411	0	VEGFR-2	90,97	Vascular_endothelial_growth_factor	0,34	VEGFR-2	Vascular endothelial growth factor	3791	7422	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Vascular_endothelial_growth_factor from Trimeresurus jerdonii venom specifically binds to VEGFR-2 .
26194852	0	VEGFR-2	47,54	Vascular_endothelial_growth_factor_receptor-2	0,45	VEGFR-2	Vascular endothelial growth factor receptor-2	3791	3791	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- inhibitors : development and validation of predictive 3-D QSAR models through extensive ligand - and structure-based approaches .
25245329	0	VEGFR-2	33,40	angiopoietin-2	6,20	VEGFR-2	angiopoietin-2	3791	285	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy_of_ovarian_neoplasm and poor prognosis in epithelial ovarian_cancer .
16049137	0	VEGFR-2	32,39	dynamin-2	19,28	VEGFR-2	dynamin-2	3791	1785	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Regulatory role of dynamin-2 in VEGFR-2 / KDR-mediated endothelial signaling .
16914140	0	VEGFR-2	110,117	tTG	54,57	VEGFR-2	tTG	3791	7052	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Complex formation between tissue_transglutaminase II -LRB- tTG -RRB- and vascular_endothelial_growth_factor_receptor_2 -LRB- VEGFR-2 -RRB- : proposed mechanism for modulation of endothelial cell response to VEGF .
10747927	0	VEGFR-2	124,131	vascular_endothelial_growth_factor	36,70	VEGFR-2	vascular endothelial growth factor	3791	7422	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|receptor-1 receptor-1|compound|END_ENTITY	Receptor chimeras indicate that the vascular_endothelial_growth_factor receptor-1 -LRB- VEGFR-1 -RRB- modulates mitogenic activity of VEGFR-2 in endothelial cells .
12551914	0	VEGFR-2	151,158	vascular_endothelial_growth_factor	47,81	VEGFR-2	vascular endothelial growth factor	3791	7422	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling essential|nmod|activation essential|nsubj|set set|nmod|END_ENTITY	A set of loop-1 and -3 structures in the novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- family member , VEGF-ENZ-7 , is essential for the activation of VEGFR-2 signaling .
15111299	0	VEGFR-2	88,95	vascular_endothelial_growth_factor	4,38	VEGFR-2	vascular endothelial growth factor	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	Flk-1|appos|START_ENTITY modulates|dobj|Flk-1 modulates|nsubj|Flt-1 Flt-1|amod|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
15946674	0	VEGFR-2	149,156	vascular_endothelial_growth_factor	102,136	VEGFR-2	vascular endothelial growth factor	3791	7422	Gene	Gene	KDR|compound|START_ENTITY receptor-2|appos|KDR receptor-2|compound|END_ENTITY	Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular_endothelial_growth_factor receptor-2 -LRB- VEGFR-2 / KDR -RRB- .
18715621	0	VEGFR-2	78,85	vascular_endothelial_growth_factor	15,49	VEGFR-2	vascular endothelial growth factor	3791	7422	Gene	Gene	VEGFR-1|dep|START_ENTITY levels|dep|VEGFR-1 levels|nmod|END_ENTITY	High levels of vascular_endothelial_growth_factor and its receptors -LRB- VEGFR-1 , VEGFR-2 , neuropilin-1 -RRB- are associated with worse outcome in breast_cancer .
19818105	0	VEGFR-2	122,129	vascular_endothelial_growth_factor	40,74	VEGFR-2	vascular endothelial growth factor	3791	7422	Gene	Gene	signaling|nmod|START_ENTITY mediated|xcomp|signaling mediated|nsubj|END_ENTITY	Alzheimer 's beta-amyloid_peptide blocks vascular_endothelial_growth_factor mediated signaling via direct interaction with VEGFR-2 .
8617204	0	VEGFR-2	96,103	vascular_endothelial_growth_factor	8,42	VEGFR-2	vascular endothelial growth factor	3791	7422	Gene	Gene	Flt4|appos|START_ENTITY ligand|nmod|Flt4 kinases|amod|ligand kinases|nsubj|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
19540581	0	VEGFR-2	70,77	vascular_endothelial_growth_factor_receptor-2	23,68	VEGFR-2	vascular endothelial growth factor receptor-2	3791	3791	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	The phosphorylation of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- by engineered surfaces with electrostatically or covalently immobilized VEGF .
23939705	0	VEGFR-3	107,114	CCR7	115,119	VEGFR-3	CCR7	2324	1236	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Hypoxia preconditioning of mesenchymal stromal cells enhances PC3 cell lymphatic metastasis accompanied by VEGFR-3 / CCR7 activation .
12393704	0	VEGFR-3	0,7	CD34	43,47	VEGFR-3	CD34	2324	947	Gene	Gene	identify|nsubj|START_ENTITY identify|dobj|population population|nmod|cells cells|compound|END_ENTITY	VEGFR-3 and CD133 identify a population of CD34 + lymphatic/vascular endothelial precursor cells .
24450475	0	VEGFR-3	6,13	CD34	0,4	VEGFR-3	CD34	2324	947	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	CD34 + VEGFR-3 + progenitor cells have a potential to differentiate towards lymphatic endothelial cells .
16076871	0	VEGFR-3	38,45	CRK	22,25	VEGFR-3	CRK	2324	1398	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation , migration , and survival of endothelial cells through the activation of ERK , AKT , and JNK pathways .
19646499	0	VEGFR-3	0,7	Flt-4	8,13	VEGFR-3	Flt-4	14257(Tax:10090)	14257(Tax:10090)	Gene	Gene	START_ENTITY|appos|mediates mediates|nsubj|END_ENTITY	VEGFR-3 / Flt-4 mediates proliferation and chemotaxis in glial precursor cells .
19901262	0	VEGFR-3	64,71	NF-kappaB	84,93	VEGFR-3	NF-kappaB	2324	4790	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1 .
11023993	0	VEGFR-3	73,80	VEGF-C	0,6	VEGFR-3	VEGF-C	2324	7424	Gene	Gene	expression|advmod|START_ENTITY expression|nsubj|END_ENTITY	VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor , VEGFR-3 , in fenestrated blood vessels in human tissues .
11683876	0	VEGFR-3	102,109	VEGF-C	61,67	VEGFR-3	VEGF-C	114110(Tax:10116)	114111(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Characterization of indolinones which preferentially inhibit VEGF-C - and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2 .
15150322	0	VEGFR-3	97,104	VEGF-C	165,171	VEGFR-3	VEGF-C	2324	7424	Gene	Gene	antibody|compound|START_ENTITY antibody|acl:relcl|antagonizes antagonizes|nmod|END_ENTITY	Involvement of the VEGF receptor 3 in tubular morphogenesis demonstrated with a human anti-human VEGFR-3 monoclonal antibody that antagonizes receptor activation by VEGF-C .
19005491	0	VEGFR-3	18,25	VEGF-C	37,43	VEGFR-3	VEGF-C	14257(Tax:10090)	22341(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin_inflammation by promoting lymphangiogenesis .
25473093	0	VEGFR-3	78,85	VEGF-C	52,58	VEGFR-3	VEGF-C	2324	7424	Gene	Gene	Vascular_Endothelial_Growth_Factor-C|appos|START_ENTITY Vascular_Endothelial_Growth_Factor-C|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor-C -LRB- VEGF-C -RRB- and Its Receptor -LRB- VEGFR-3 -RRB- in the Glial Reaction Elicited by Human Mesenchymal Stem Cell Engraftment in the Normal Rat Brain .
8617204	0	VEGFR-3	78,85	VEGF-C	44,50	VEGFR-3	VEGF-C	2324	7424	Gene	Gene	Flt4|appos|START_ENTITY ligand|nmod|Flt4 kinases|amod|ligand kinases|nsubj|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
17951197	0	VEGFR-3	27,34	VEGF-D	0,6	VEGFR-3	VEGF-D	2324	2277	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	VEGF-D in association with VEGFR-3 promotes nodal metastasis in human invasive lobular breast_cancer .
8617204	0	VEGFR-3	78,85	vascular_endothelial_growth_factor	8,42	VEGFR-3	vascular endothelial growth factor	2324	7422	Gene	Gene	Flt4|appos|START_ENTITY ligand|nmod|Flt4 kinases|amod|ligand kinases|nsubj|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
14716745	0	VEGFR-3	61,68	vascular_endothelial_growth_factor_receptor-3	14,59	VEGFR-3	vascular endothelial growth factor receptor-3	2324	2324	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor_receptor-3 -LRB- VEGFR-3 -RRB- in human prostate .
23809370	0	VEGFR1	81,87	CXCR4	73,78	VEGFR1	CXCR4	14254(Tax:10090)	12767(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	NSAID , aspirin delays gastric_ulcer_healing with reduced accumulation of CXCR4 -LRB- + -RRB- VEGFR1 -LRB- + -RRB- cells to the ulcer granulation tissues .
23982810	0	VEGFR1	173,179	CXCR4	180,185	VEGFR1	CXCR4	14254(Tax:10090)	12767(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Vascular_endothelial_growth_factor_receptor_1 signaling facilitates gastric ulcer_healing and angiogenesis through the upregulation of epidermal_growth_factor expression on VEGFR1 + CXCR4 + cells recruited from bone marrow .
26124351	0	VEGFR1	37,43	HER2	73,77	VEGFR1	HER2	2321	2064	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Status Status|compound|END_ENTITY	Prognostic Significance of VEGFC and VEGFR1 mRNA Expression According to HER2 Status in Breast_Cancer : A Study of Primary_Tumors from Patients with High-risk Early Breast_Cancer Participating in a Randomized Hellenic Cooperative Oncology Group Trial .
26284550	0	VEGFR1	18,24	MMP14	0,5	VEGFR1	MMP14	14254(Tax:10090)	17387(Tax:10090)	Gene	Gene	Cleavage|nmod|START_ENTITY Cleavage|compound|END_ENTITY	MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect .
26284550	0	VEGFR1	18,24	MMP14	0,5	VEGFR1	MMP14	14254(Tax:10090)	17387(Tax:10090)	Gene	Gene	Cleavage|nmod|START_ENTITY Cleavage|compound|END_ENTITY	MMP14 Cleavage of VEGFR1 in the Cornea Leads to a VEGF-Trap Antiangiogenic Effect .
19302266	0	VEGFR1	0,6	Rab4	24,28	VEGFR1	Rab4	2321	5867	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	VEGFR1 -LRB- Flt1 -RRB- regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching .
21285868	0	VEGFR1	48,54	VEGF_A	22,28	VEGFR1	VEGF A	2321	7422	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of VEGF_A and its receptors , VEGFR1 and VEGFR2 , in the liver from patients with biliary_atresia .
23982810	0	VEGFR1	173,179	epidermal_growth_factor	135,158	VEGFR1	epidermal growth factor	14254(Tax:10090)	13645(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Vascular_endothelial_growth_factor_receptor_1 signaling facilitates gastric ulcer_healing and angiogenesis through the upregulation of epidermal_growth_factor expression on VEGFR1 + CXCR4 + cells recruited from bone marrow .
18356031	0	VEGFR1	98,104	vascular_endothelial_growth_factor_A	34,70	VEGFR1	vascular endothelial growth factor A	2321	7422	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor_A -LRB- VEGF -RRB- , and its receptors -LRB- VEGFR1 , 2 -RRB- in normal and pathologic conditions of the human thymus .
21386843	0	VEGFR2	38,44	CD34	31,35	VEGFR2	CD34	3791	947	Gene	Gene	START_ENTITY|nsubj|Levels Levels|nmod|END_ENTITY	Levels of circulating CD45 -LRB- dim -RRB- CD34 -LRB- + -RRB- VEGFR2 -LRB- + -RRB- progenitor cells correlate with outcome in metastatic_renal_cell_carcinoma patients treated with tyrosine kinase inhibitors .
20445540	0	VEGFR2	20,26	Ephrin-B2	0,9	VEGFR2	Ephrin-B2	16542(Tax:10090)	13642(Tax:10090)	Gene	Gene	function|nummod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis .
23202541	0	VEGFR2	19,25	FOXP3	13,18	VEGFR2	FOXP3	3791	50943	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Intratumoral FOXP3 + VEGFR2 + regulatory T cells are predictive markers for recurrence and survival in patients with colorectal_cancer .
20660291	0	VEGFR2	63,69	Gremlin	0,7	VEGFR2	Gremlin	3791	26585	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2 .
19426150	0	VEGFR2	0,6	PDGFRbeta	7,16	VEGFR2	PDGFRbeta	3791	5159	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	VEGFR2 + PDGFRbeta + circulating precursor cells participate in capillary restoration after hyperoxia_acute_lung_injury -LRB- HALI -RRB- .
24585635	0	VEGFR2	76,82	SRC-3	57,62	VEGFR2	SRC-3	3791	8202	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	ERK3 promotes endothelial cell functions by upregulating SRC-3 / SP1-mediated VEGFR2 expression .
17009627	0	VEGFR2	54,60	STAT3	32,37	VEGFR2	STAT3	3791	6774	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian_carcinoma cells in vitro .
24785348	0	VEGFR2	41,47	Tyrosine_Kinase	57,72	VEGFR2	Tyrosine Kinase	796537(Tax:7955)	30256(Tax:7955)	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine_Kinase Regulates Endothelial Function and Blood Vessel Formation .
23708980	0	VEGFR2	30,36	UQCRB	14,19	VEGFR2	UQCRB	3791	7381	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Mitochondrial UQCRB regulates VEGFR2 signaling in endothelial cells .
10744763	0	VEGFR2	85,91	VEGF	36,40	VEGFR2	VEGF	3791	7422	Gene	Gene	mediated|nmod|START_ENTITY driven|ccomp|mediated Vascular_endothelial_growth_factor|acl|driven Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated_protein_kinase_2 -LRB- SAPK2/p38 -RRB- and geldanamycin-sensitive phosphorylation of focal_adhesion_kinase .
12406893	0	VEGFR2	32,38	VEGF	135,139	VEGFR2	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY culture|nmod|cells reveals|nsubj|culture reveals|advcl|tuning tuning|dobj|threshold threshold|nmod|END_ENTITY	A chemically defined culture of VEGFR2 + cells derived from embryonic stem cells reveals the role of VEGFR1 in tuning the threshold for VEGF in developing endothelial cells .
12549858	0	VEGFR2	50,56	VEGF	34,38	VEGFR2	VEGF	3791	7422	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	A monoclonal antibody that blocks VEGF binding to VEGFR2 -LRB- KDR/Flk -1 -RRB- inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast_cancer model .
15328520	0	VEGFR2	23,29	VEGF	86,90	VEGFR2	VEGF	3791	7422	Gene	Gene	efficacy|nmod|START_ENTITY tyrosine|nsubj|efficacy tyrosine|nmod|expression expression|nmod|END_ENTITY	Antitumour efficacy of VEGFR2 tyrosine kinase inhibitor correlates with expression of VEGF and its receptor VEGFR2 in tumour models .
17009627	0	VEGFR2	54,60	VEGF	0,4	VEGFR2	VEGF	3791	7422	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	VEGF induces phosphorylation of STAT3 through binding VEGFR2 in ovarian_carcinoma cells in vitro .
23454747	0	VEGFR2	11,17	VEGF	6,10	VEGFR2	VEGF	3791	7422	Gene	Gene	loop|nummod|START_ENTITY triggers|nsubj|loop END_ENTITY|parataxis|triggers	Tumor VEGF : VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung_cancer .
23896411	0	VEGFR2	74,80	VEGF	27,31	VEGFR2	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY recruiting|nmod|cells modulates|advcl|recruiting modulates|dobj|signaling signaling|compound|END_ENTITY	Thrombospondin-1 modulates VEGF signaling via CD36 by recruiting SHP-1 to VEGFR2 complex in microvascular endothelial cells .
24986423	0	VEGFR2	64,70	VEGF	0,4	VEGFR2	VEGF	443087(Tax:9940)	443103(Tax:9940)	Gene	Gene	stimulation|compound|START_ENTITY permeability|nmod|stimulation increases|dobj|permeability increases|nsubj|END_ENTITY	VEGF increases the permeability of sheep pleura ex vivo through VEGFR2 stimulation .
27105528	0	VEGFR2	63,69	VEGF	47,51	VEGFR2	VEGF	3791	7422	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2 .
19875757	0	VEGFR2	84,90	VEGFA	58,63	VEGFR2	VEGFA	3791	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Clinical relevance of vascular_endothelial_growth_factor -LRB- VEGFA -RRB- and VEGF receptor -LRB- VEGFR2 -RRB- gene polymorphism on the treatment outcome following imatinib therapy .
26476544	0	VEGFR2	78,84	VEGFA	53,58	VEGFR2	VEGFA	3791	7422	Gene	Gene	Vascular_Endothelial_Growth_Factor_A|appos|START_ENTITY Vascular_Endothelial_Growth_Factor_A|appos|END_ENTITY	Association of Vascular_Endothelial_Growth_Factor_A -LRB- VEGFA -RRB- and its Receptor -LRB- VEGFR2 -RRB- Gene Polymorphisms with Risk of Chronic_Myeloid_Leukemia and Influence on Clinical Outcome .
25102966	0	VEGFR2	17,23	VEGF_receptor_2	0,15	VEGFR2	VEGF receptor 2	3791	3791	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	VEGF_receptor_2 -LRB- VEGFR2 -RRB- activation is essential for osteocyte survival induced by mechanotransduction .
25488616	0	VEGFR2	98,104	VEGF_receptor_type_2	76,96	VEGFR2	VEGF receptor type 2	3791	3791	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Clinical relevance of vascular_endothelial_growth_factor_type_A -LRB- VEGFA -RRB- and VEGF_receptor_type_2 -LRB- VEGFR2 -RRB- gene polymorphism in chronic lymphocytic_leukemia .
22426130	0	VEGFR2	92,98	heme_oxygenase-1	71,87	VEGFR2	heme oxygenase-1	3791	3162	Gene	Gene	upregulation|compound|START_ENTITY END_ENTITY|nmod|upregulation	PDGF-induced migration of vascular smooth muscle cells is inhibited by heme_oxygenase-1 via VEGFR2 upregulation and subsequent assembly of inactive VEGFR2/PDGFRb heterodimers .
26956185	0	VEGFR2	135,141	miR-126	127,134	VEGFR2	miR-126	3791	406913	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	The effects of microvesicles on endothelial progenitor cells are compromised in type 2 diabetic patients via downregulation of miR-126 / VEGFR2 pathway .
25424874	0	VEGFR2	16,22	vascular_endothelial_growth_factor_receptor	24,67	VEGFR2	vascular endothelial growth factor receptor	3791	3791	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Quantitation of VEGFR2 -LRB- vascular_endothelial_growth_factor_receptor -RRB- inhibitors - review of assay methodologies and perspectives .
23552426	0	VEGFR3	40,46	Ets-1	0,5	VEGFR3	Ets-1	2324	2113	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Ets-1 is required for the activation of VEGFR3 during latent Kaposi 's _ sarcoma-associated_herpesvirus_infection of endothelial cells .
24710631	0	VEGFR3	68,74	vascular_endothelial_growth_factor_receptor-3	21,66	VEGFR3	vascular endothelial growth factor receptor-3	2324	2324	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcription of the vascular_endothelial_growth_factor_receptor-3 -LRB- VEGFR3 -RRB- gene is regulated by the zinc finger proteins Sp1 and Sp3 and is under epigenetic control : transcription of vascular endothelial growth factor receptor 3 .
21285868	0	VEGF_A	22,28	VEGFR1	48,54	VEGF A	VEGFR1	7422	2321	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of VEGF_A and its receptors , VEGFR1 and VEGFR2 , in the liver from patients with biliary_atresia .
18798279	0	VEGF_C	19,25	Heparanase	0,10	VEGF C	Heparanase	7424	10855	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Heparanase induces VEGF_C and facilitates tumor lymphangiogenesis .
20966350	0	VEGF_receptor-2	26,41	Klotho	0,6	VEGF receptor-2	Klotho	16542(Tax:10090)	16591(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Klotho is associated with VEGF_receptor-2 and the transient receptor potential canonical-1 Ca2 + channel to maintain endothelial integrity .
20923780	0	VEGF_receptor-2	26,41	Thrombospondin-1	0,16	VEGF receptor-2	Thrombospondin-1	3791	7057	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Thrombospondin-1 inhibits VEGF_receptor-2 signaling by disrupting its association with CD47 .
25797338	0	VEGF_receptor_2	62,77	Flk-1	79,84	VEGF receptor 2	Flk-1	16542(Tax:10090)	16542(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA , VEGF_receptor_2 -LRB- Flk-1 -RRB- mRNA , and of VEGF co-receptor neuropilin -LRB- Nrp -RRB- -1 mRNA in brain tissue of aging Tg2576 mice by in situ hybridization .
18155761	0	VEGF_receptor_2	57,72	VEGF	48,52	VEGF receptor 2	VEGF	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	The role of actively released fibrin-conjugated VEGF for VEGF_receptor_2 gene activation and the enhancement of angiogenesis .
25102966	0	VEGF_receptor_2	0,15	VEGFR2	17,23	VEGF receptor 2	VEGFR2	3791	3791	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	VEGF_receptor_2 -LRB- VEGFR2 -RRB- activation is essential for osteocyte survival induced by mechanotransduction .
25488616	0	VEGF_receptor_type_2	76,96	VEGFR2	98,104	VEGF receptor type 2	VEGFR2	3791	3791	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical relevance of vascular_endothelial_growth_factor_type_A -LRB- VEGFA -RRB- and VEGF_receptor_type_2 -LRB- VEGFR2 -RRB- gene polymorphism in chronic lymphocytic_leukemia .
26287601	0	VEGFa	103,108	HIF1a	78,83	VEGFa	HIF1a	7422	3091	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	NCOA1 promotes angiogenesis in breast_tumors by simultaneously enhancing both HIF1a - and AP-1-mediated VEGFa transcription .
25050010	0	VEGFa	103,108	Vascular_Endothelial_Growth_Factor_Alpha	61,101	VEGFa	Vascular Endothelial Growth Factor Alpha	100033839(Tax:9796)	100033839(Tax:9796)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Molecular Characterization and Expression Analysis of Equine Vascular_Endothelial_Growth_Factor_Alpha -LRB- VEGFa -RRB- Gene in Horse -LRB- Equus_caballus -RRB- .
12058196	0	VEGI	47,51	Vascular_Endothelial_Cell_Growth_Inhibitor	66,108	VEGI	Vascular Endothelial Cell Growth Inhibitor	9966	9966	Gene	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Cloning , Expression and Biological Activity of VEGI -LRB- 151 -RRB- , a Novel Vascular_Endothelial_Cell_Growth_Inhibitor .
20150621	0	VEGI	53,57	vascular_endothelial_growth_inhibitor	14,51	VEGI	vascular endothelial growth inhibitor	9966	9966	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_inhibitor -LRB- VEGI -RRB- in human urothelial_cancer_of_the_bladder and its effects on the adhesion and migration of bladder_cancer cells in vitro .
10656251	0	VEMA	26,30	ventral_midline_antigen	40,63	VEMA	ventral midline antigen	291948(Tax:10116)	291948(Tax:10116)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|dep|END_ENTITY	Cloning and expression of VEMA : a novel ventral_midline_antigen in the rat CNS .
19166903	0	VEP1	4,8	At4g24220	15,24	VEP1	At4g24220	828523(Tax:3702)	828523(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The VEP1 gene -LRB- At4g24220 -RRB- encodes a short-chain dehydrogenase/reductase with 3-oxo-Delta4 ,5 - steroid_5beta-reductase activity in Arabidopsis_thaliana L .
26212236	0	VGF	47,50	DISC1	0,5	VGF	DISC1	381677(Tax:10090)	244667(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway .
15103023	0	VGLUT1	57,63	vesicular_glutamate_transporter_1	22,55	VGLUT1	vesicular glutamate transporter 1	72961(Tax:10090)	72961(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	An essential role for vesicular_glutamate_transporter_1 -LRB- VGLUT1 -RRB- in postnatal development and control of quantal size .
18155072	0	VGLUT2	59,65	vesicular_glutamate_transporter_2	24,57	VGLUT2	vesicular glutamate transporter 2	57084	57084	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Antipsychotics increase vesicular_glutamate_transporter_2 -LRB- VGLUT2 -RRB- expression in thalamolimbic pathways .
22684983	0	VGluT2	51,57	vesicular_glutamate_transporter_2	16,49	VGluT2	vesicular glutamate transporter 2	57084	57084	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of vesicular_glutamate_transporter_2 -LRB- VGluT2 -RRB- in the primary visual cortex of the macaque and human .
16585181	0	VHL	39,42	E-cadherin	14,24	VHL	E-cadherin	7428	999	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of E-cadherin expression by VHL and hypoxia-inducible factor .
17060462	0	VHL	0,3	E-cadherin	30,40	VHL	E-cadherin	7428	999	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|transcription transcription|amod|END_ENTITY	VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail .
17245122	0	VHL	12,15	E-cadherin	37,47	VHL	E-cadherin	7428	999	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of VHL in the regulation of E-cadherin : a new connection in an old pathway .
22440786	0	VHL	161,164	FHIT	145,149	VHL	FHIT	7428	2272	Gene	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	Enduring response to everolimus as third-line therapy in a patient with advanced_renal_cell_carcinoma , including small-bowel metastases : loss of FHIT but normal VHL gene status .
11504942	0	VHL	22,25	HIF-1alpha	0,10	VHL	HIF-1alpha	7428	3091	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation .
12205091	0	VHL	62,65	HIF-1alpha	11,21	VHL	HIF-1alpha	7428	3091	Gene	Gene	von_Hippel-Lindau|appos|START_ENTITY essential|nmod|von_Hippel-Lindau essential|nsubj|Leu-574 Leu-574|nmod|END_ENTITY	Leu-574 of HIF-1alpha is essential for the von_Hippel-Lindau -LRB- VHL -RRB- - mediated degradation pathway .
12682018	0	VHL	4,7	HIF-1alpha	66,76	VHL	HIF-1alpha	7428	3091	Gene	Gene	protein|compound|START_ENTITY recruits|nsubj|protein recruits|nmod|activity activity|compound|END_ENTITY	The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity .
16954163	0	VHL	112,115	HIF-1alpha	14,24	VHL	HIF-1alpha	7428	3091	Gene	Gene	mutations|compound|START_ENTITY Expression|nmod|mutations Expression|nmod|END_ENTITY	Expression of HIF-1alpha , HIF-2alpha -LRB- EPAS1 -RRB- , and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations .
18717335	0	VHL	67,70	HIF-1alpha	38,48	VHL	HIF-1alpha	7428	3091	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	-LSB- Hydroxysafflor_yellow_A up-regulates HIF-1alpha via inhibition of VHL and p53 in Eahy 926 cell line exposed to hypoxia -RSB- .
20075985	0	VHL	79,82	HIF-1alpha	19,29	VHL	HIF-1alpha	7428	3091	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of HIF-1alpha by oncolytic reovirus_infection independently of VHL and p53 .
20599784	0	VHL	97,100	HIF-1alpha	66,76	VHL	HIF-1alpha	7428	3091	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	LW6 , a novel HIF-1 inhibitor , promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon_cancer cell line .
16856496	0	VHL	33,36	Mnk2	20,24	VHL	Mnk2	7428	2872	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between Mnk2 and CBC -LRB- VHL -RRB- ubiquitin ligase E3 complex .
24915993	0	VHL	50,53	Nm23	20,24	VHL	Nm23	7428	4830	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between Nm23 and the tumor suppressor VHL .
25500545	0	VHL	15,18	RSUME	0,5	VHL	RSUME	7428	25950	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	RSUME inhibits VHL and regulates its tumor suppressor function .
8674032	0	VHL	76,79	VBP-1	35,40	VHL	VBP-1	7428	7411	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Identification of a novel protein -LRB- VBP-1 -RRB- binding to the von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor suppressor gene product .
18209888	0	VHL	45,48	Von_Hippel-Lindau	26,43	VHL	Von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular analysis of the Von_Hippel-Lindau -LRB- VHL -RRB- gene in a family with non-syndromic_pheochromocytoma : the importance of genetic testing .
8956040	0	VHL	53,56	Von_Hippel-Lindau_disease	26,51	VHL	Von Hippel-Lindau disease	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Germline mutations in the Von_Hippel-Lindau_disease -LRB- VHL -RRB- gene in families from North America , Europe , and Japan .
25749518	0	VHL	43,46	ZBRK1	0,5	VHL	ZBRK1	7428	59348	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	ZBRK1 , a novel tumor suppressor , activates VHL gene transcription through formation of a complex with VHL and p300 in renal_cancer .
22043236	0	VHL	46,49	microRNA-92	22,33	VHL	microRNA-92	7428	407047	Gene	Gene	Expression|compound|START_ENTITY Effects|nmod|Expression Effects|nmod|END_ENTITY	Regulatory Effects of microRNA-92 -LRB- miR-92 -RRB- on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear_Cell_Renal_Cell_Carcinoma .
11313969	0	VHL	3,6	p53	24,27	VHL	p53	7428	7157	Gene	Gene	mirror|nsubj|START_ENTITY mirror|dobj|END_ENTITY	Do VHL and HIF-1 mirror p53 and Mdm-2 ?
16969113	0	VHL	55,58	p53	27,30	VHL	p53	7428	7157	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	The positive regulation of p53 by the tumor suppressor VHL .
10830910	0	VHL	85,88	von_Hippel-Lindau	66,83	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotype-phenotype correlations in families with deletions in the von_Hippel-Lindau -LRB- VHL -RRB- gene .
11585776	0	VHL	38,41	von_Hippel-Lindau	19,36	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of ras and von_Hippel-Lindau -LRB- VHL -RRB- gene mutations on hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 alpha , HIF-2alpha , and vascular_endothelial_growth_factor expression and their regulation by the phosphatidylinositol_3 ' - kinase/Akt signaling pathway .
11967908	0	VHL	36,39	von_Hippel-Lindau	17,34	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the von_Hippel-Lindau -LRB- VHL -RRB- gene refine differential diagnostic criteria in renal_cell_carcinoma .
14767077	0	VHL	126,129	von_Hippel-Lindau	131,148	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction -- the case of VHL -LRB- von_Hippel-Lindau -RRB- protein and angiogenesis regulatory pathway .
14965365	0	VHL	35,38	von_Hippel-Lindau	16,33	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutation of the von_Hippel-Lindau -LRB- VHL -RRB- gene in human colorectal_carcinoma : association with cytoplasmic accumulation of hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 alpha .
16884328	0	VHL	72,75	von_Hippel-Lindau	53,70	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of large deletions in the von_Hippel-Lindau -LRB- VHL -RRB- gene by quantitative real-time PCR : the hypothesis of an alu-mediated mechanism underlying VHL gene rearrangements .
17102087	0	VHL	40,43	von_Hippel-Lindau	21,38	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Germline mutation of von_Hippel-Lindau -LRB- VHL -RRB- gene 695_G > A -LRB- R161Q -RRB- in a patient with a peculiar phenotype with type 2C VHL_syndrome .
18481984	0	VHL	12,15	von_Hippel-Lindau	17,34	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Role of the VHL -LRB- von_Hippel-Lindau -RRB- gene in renal cancer : a multifunctional tumour suppressor .
19933033	0	VHL	62,65	von_Hippel-Lindau	43,60	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of somatic mutations in the von_Hippel-Lindau -LRB- VHL -RRB- gene in a patient with renal_cell_carcinoma .
22357874	0	VHL	49,52	von_Hippel-Lindau	30,47	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Agents that stabilize mutated von_Hippel-Lindau -LRB- VHL -RRB- protein : results of a high-throughput screen to identify compounds that modulate VHL proteostasis .
23626751	0	VHL	30,33	von_Hippel-Lindau	11,28	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	P.Arg82Leu von_Hippel-Lindau -LRB- VHL -RRB- gene mutation among three members of a family with familial_bilateral_pheochromocytoma in India : molecular analysis and in silico characterization .
24727139	0	VHL	59,62	von_Hippel-Lindau	40,57	VHL	von Hippel-Lindau	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Unique molecular alteration patterns in von_Hippel-Lindau -LRB- VHL -RRB- gene in a cohort of sporadic_renal_cell_carcinoma patients from Pakistan .
11081202	0	VHL-P	41,46	von_Hippel-Lindau_protein	14,39	VHL-P	von Hippel-Lindau protein	391104	391104	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of von_Hippel-Lindau_protein -LRB- VHL-P -RRB- in nontumorous and adenomatous human pituitaries .
16533810	0	VHT1	95,99	Vhr1p	0,5	VHT1	Vhr1p	852956(Tax:4932)	854755(Tax:4932)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Vhr1p , a new transcription factor from budding yeast , regulates biotin-dependent expression of VHT1 and BIO5 .
10410309	0	VIII	50,54	FVIII	56,61	VIII	FVIII	1351	2157	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of recombinant blood_coagulation factor VIII -LRB- FVIII -RRB- heavy and light chains and reconstitution of active form of FVIII .
26340413	0	VIII	62,66	Thrombin	0,8	VIII	Thrombin	1351	2147	Gene	Gene	using|nmod|START_ENTITY using|nsubj|assay assay|compound|END_ENTITY	Thrombin generation assay using factor XIa to measure factors VIII and IX and their glycoPEGylated derivatives is robust and sensitive .
638056	0	VIII	30,34	Thrombin	0,8	VIII	Thrombin	1351	2147	Gene	Gene	factor|nummod|START_ENTITY activation|nmod|factor activation|compound|END_ENTITY	Thrombin activation of factor VIII .
1902744	0	VIII	38,42	VIII	82,86	VIII	VIII	1351	1351	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors .
1902744	0	VIII	82,86	VIII	38,42	VIII	VIII	1351	1351	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Variable inactivation of human factor VIII from different sources by human factor VIII inhibitors .
6424471	0	VIII	70,74	growth_hormone	103,117	VIII	growth hormone	1351	2688	Gene	Gene	response|nummod|START_ENTITY response|nmod|infusion infusion|compound|END_ENTITY	Lack of von_Willebrand factor , factor VIII related antigen and factor VIII coagulant response to human growth_hormone infusion in type 2 diabetes_mellitus .
6438437	0	VIII	40,44	growth_hormone	11,25	VIII	growth hormone	1351	2688	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of growth_hormone on the factor VIII complex in patients with growth_hormone deficiency .
6438437	0	VIII	40,44	growth_hormone	70,84	VIII	growth hormone	1351	2688	Gene	Gene	START_ENTITY|xcomp|complex complex|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Effects of growth_hormone on the factor VIII complex in patients with growth_hormone deficiency .
137671	0	VIII	69,73	thrombin	32,40	VIII	thrombin	1351	2147	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	In vivo and in vitro effects of thrombin and plasmin on human factor VIII -LRB- AHF -RRB- .
24354535	0	VIII	96,100	thrombin	131,139	VIII	thrombin	1351	2147	Gene	Gene	factor|nummod|START_ENTITY access|nmod|factor Pakistan|nmod|access cohort|nmod|Pakistan scores|nmod|cohort concentrate|nsubj|scores concentrate|dobj|correlation correlation|nmod|generation generation|compound|END_ENTITY	Joint health scores in a haemophilia_A cohort from Pakistan with minimal or no access to factor VIII concentrate : correlation with thrombin generation and underlying mutation .
3082357	1	VIII	170,174	thrombin	82,90	VIII	thrombin	1351	2147	Gene	Gene	activity|nummod|START_ENTITY Correlation|nmod|activity Correlation|nmod|END_ENTITY	Correlation of specific cleavages by thrombin , factor_Xa , and activated_protein_C with activation and inactivation of factor VIII coagulant activity .
3085715	0	VIII	25,29	thrombin	71,79	VIII	thrombin	1351	2147	Gene	Gene	heterodimers|compound|START_ENTITY size|nmod|heterodimers produced|nsubj|size produced|nmod|END_ENTITY	The size of human factor VIII heterodimers and the effects produced by thrombin .
3099625	2	VIII	96,100	thrombin	116,124	VIII	thrombin	1351	2147	Gene	Gene	proteolysis|nummod|START_ENTITY proteolysis|nmod|END_ENTITY	Antibody binding prevents factor VIII proteolysis by thrombin .
505400	0	VIII	79,83	thrombin	17,25	VIII	thrombin	1351	2147	Gene	Gene	activity|nmod|START_ENTITY influence|nmod|activity influence|nmod|END_ENTITY	The influence of thrombin on the platelet-aggregating activity of human factor VIII .
505401	0	VIII	23,27	thrombin	76,84	VIII	thrombin	1351	2147	Gene	Gene	START_ENTITY|nmod|independent independent|nmod|generation generation|nmod|END_ENTITY	Inactivation of factor VIII by a mechanism independent of the generation of thrombin .
6778941	0	VIII	39,43	thrombin	14,22	VIII	thrombin	1351	2147	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of thrombin on human factor VIII .
6779877	0	VIII	48,52	thrombin	90,98	VIII	thrombin	1351	2147	Gene	Gene	activation|nmod|START_ENTITY activation|dep|effect effect|nmod|inhibitors inhibitors|nmod|END_ENTITY	The activation and inactivation of human factor VIII by thrombin : effect of inhibitors of thrombin .
6794678	0	VIII	78,82	thrombin	97,105	VIII	thrombin	1351	2147	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	Combined factor V-VIII deficiency : a case report with studies of factor V and VIII activation by thrombin .
8907177	0	VIII	88,92	thrombin	109,117	VIII	thrombin	1351	2147	Gene	Gene	activation|nmod|START_ENTITY glycosaminoglycan|nmod|activation Effect|nmod|glycosaminoglycan V|nsubj|Effect V|nmod|END_ENTITY	Effect of depolymerized holothurian glycosaminoglycan -LRB- DHG -RRB- on the activation of factor VIII and factor V by thrombin .
427046	0	VIII	26,30	vasopressin	43,54	VIII	vasopressin	1351	551	Gene	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Specificity in the factor VIII response to vasopressin infusion in man .
8710169	0	VILIP	38,43	visinin-like_protein	16,36	VILIP	visinin-like protein	396189(Tax:9031)	396189(Tax:9031)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Distribution of visinin-like_protein -LRB- VILIP -RRB- immunoreactivity in the hippocampus of the Mongolian gerbil -LRB- Meriones unguiculatus -RRB- .
11108936	0	VIP	0,3	CD4	61,64	VIP	CD4	7432	920	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	VIP and PACAP inhibit Fas_ligand-mediated bystander lysis by CD4 -LRB- + -RRB- T cells .
10036238	0	VIP	103,106	CFTR	0,4	VIP	CFTR	117064(Tax:10116)	24255(Tax:10116)	Gene	Gene	upregulated|nmod|START_ENTITY villus|ccomp|upregulated villus|nsubj|insertion insertion|amod|END_ENTITY	CFTR channel insertion to the apical surface in rat duodenal villus epithelial cells is upregulated by VIP in vivo .
24788249	0	VIP	0,3	CFTR	14,18	VIP	CFTR	7432	1080	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1 - and PKC - dependent manner .
938120	0	VIP	132,135	GIP	88,91	VIP	GIP	484038(Tax:9615)	609020(Tax:9615)	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide -LRB- GIP -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- .
11445245	0	VIP	84,87	GRF	42,45	VIP	GRF	7432	2691	Gene	Gene	activity|compound|START_ENTITY due|nmod|activity due|nsubj|side-effects side-effects|nmod|analogue analogue|compound|END_ENTITY	GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity .
2853835	0	VIP	46,49	GRF	88,91	CRF	GRF	81648(Tax:10116)	29446(Tax:10116)	Gene	Gene	peptide|appos|START_ENTITY peptide|appos|END_ENTITY	Interaction of vasoactive intestinal peptide -LRB- VIP -RRB- and growth_hormone_releasing_factor -LRB- GRF -RRB- with corticotropin_releasing_factor -LRB- CRF -RRB- on corticotropin secretion in vitro .
2859987	0	VIP	108,111	GRF	48,51	VIP	GRF	117064(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY analogs|nmod|receptors analogs|nsubj|Interaction Interaction|nmod|growth_hormone-releasing_factor growth_hormone-releasing_factor|appos|END_ENTITY	Interaction of growth_hormone-releasing_factor -LRB- GRF -RRB- and 14 GRF analogs with vasoactive intestinal peptide -LRB- VIP -RRB- receptors of rat pancreas .
2859987	1	VIP	191,194	GRF	172,175	VIP	GRF	117064(Tax:10116)	29446(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY NH2|nmod|antagonist Discovery|dep|NH2 Discovery|nmod|END_ENTITY	Discovery of -LRB- N-Ac-Tyr1 , D-Phe2 -RRB- - GRF -LRB- 1-29 -RRB- - NH2 as a VIP antagonist .
3003561	0	VIP	118,121	GRF	139,142	VIP	GRF	117064(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY intestinal|dobj|receptors intestinal|xcomp|using using|dobj|receptors receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	118,121	GRF	65,68	VIP	GRF	117064(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY intestinal|dobj|receptors intestinal|nsubj|Study Study|nmod|specificity specificity|nmod|interaction interaction|appos|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	158,161	GRF	139,142	VIP	GRF	117064(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	158,161	GRF	65,68	VIP	GRF	117064(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY using|dobj|receptors intestinal|xcomp|using intestinal|nsubj|Study Study|nmod|specificity specificity|nmod|interaction interaction|appos|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	235,238	GRF	139,142	VIP	GRF	7432	29446(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY intestinal|ccomp|antagonist intestinal|xcomp|using using|dobj|receptors receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	235,238	GRF	65,68	VIP	GRF	7432	29446(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY intestinal|ccomp|antagonist intestinal|nsubj|Study Study|nmod|specificity specificity|nmod|interaction interaction|appos|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
8099848	0	VIP	84,87	IL-2	172,176	VIP	IL-2	22353(Tax:10090)	16183(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|production production|compound|END_ENTITY	Modulation of T lymphocyte proliferation in mice infected with Schistosoma_mansoni : VIP suppresses mitogen - and antigen-induced T cell proliferation possibly by inhibiting IL-2 production .
16999955	0	VIP	0,3	Nurr1	35,40	VIP	Nurr1	7432	4929	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	VIP is a transcriptional target of Nurr1 in dopaminergic cells .
1421089	0	VIP	23,26	Oncostatin_M	0,12	VIP	Oncostatin M	7432	5008	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oncostatin_M regulates VIP expression in a human neuroblastoma cell line .
8923513	0	VIP	0,3	PACAP	60,65	VIP	PACAP	7432	116	Gene	Gene	polypeptide|compound|START_ENTITY polypeptide|appos|END_ENTITY	VIP and pituitary adenylate cyclase activating polypeptide -LRB- PACAP -RRB- have an antiproliferative effect on the T98G human glioblastoma cell line through interaction with VIP2 receptor .
20019164	0	VIP	33,36	Progesterone_receptor_A	0,23	VIP	Progesterone receptor A	100735454	100462900	Gene	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Progesterone_receptor_A mediates VIP inhibition of contraction .
16888154	0	VIP	10,13	TLR2	17,21	VIP	TLR2	22353(Tax:10090)	24088(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS-induced colitis .
16319097	0	VIP	0,3	TLR4	19,23	VIP	TLR4	7432	7099	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|compound|END_ENTITY	VIP down-regulates TLR4 expression and TLR4-mediated chemokine production in human rheumatoid synovial fibroblasts .
27026343	0	VIP	0,3	TNF-a	101,106	VIP	TNF-a	7432	7124	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-a and enhances RvD1 .
15857940	0	VIP	110,113	Toll-like_receptors_2_and_4	26,53	VIP	Toll-like receptors 2 and 4	7432	7097;7099	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Time-course expression of Toll-like_receptors_2_and_4 in inflammatory_bowel_disease and homeostatic effect of VIP .
1897456	0	VIP	40,43	VIP	52,55	VIP	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	-LSB- The influence of the light stimulus on VIP mRNA in VIP containing neurons of the rat suprachiasmatic nucleus -RSB- .
1897456	0	VIP	52,55	VIP	40,43	VIP	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	-LSB- The influence of the light stimulus on VIP mRNA in VIP containing neurons of the rat suprachiasmatic nucleus -RSB- .
3003561	0	VIP	118,121	VIP	158,161	VIP	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY intestinal|dobj|receptors intestinal|xcomp|using using|dobj|receptors receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	158,161	VIP	118,121	VIP	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY using|dobj|receptors intestinal|xcomp|using intestinal|dobj|receptors receptors|appos|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	158,161	VIP	235,238	VIP	VIP	117064(Tax:10116)	7432	Gene	Gene	receptors|compound|START_ENTITY using|dobj|receptors intestinal|xcomp|using intestinal|ccomp|antagonist antagonist|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
3003561	0	VIP	235,238	VIP	158,161	VIP	VIP	7432	117064(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY intestinal|ccomp|antagonist intestinal|xcomp|using using|dobj|receptors receptors|compound|END_ENTITY	Study of species specificity in growth_hormone-releasing_factor -LRB- GRF -RRB- interaction with vasoactive intestinal peptide -LRB- VIP -RRB- receptors using GRF and intestinal VIP receptors from rat and human : evidence that Ac-Tyr1hGRF is a competitive VIP antagonist in the rat .
14744818	0	VIP	33,36	VPAC1	14,19	VIP	VPAC1	7432	7433	Gene	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Activation of VPAC1 receptors by VIP and PACAP-27 in human bronchial epithelial cells induces CFTR-dependent chloride secretion .
10683516	0	VIP	18,21	c-Jun	73,78	VIP	c-Jun	7432	3725	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	The neuropeptides VIP and PACAP inhibit IL-2 transcription by decreasing c-Jun and increasing JunB expression in T cells .
11938800	0	VIP	41,44	epidermal_growth_factor	14,37	VIP	epidermal growth factor	7432	1950	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Affection of epidermal_growth_factor on VIP secretion and VIPR expression in airway epithelial cells -RSB- .
938120	0	VIP	132,135	gastrin	15,22	VIP	gastrin	484038(Tax:9615)	100685087	Gene	Gene	polypeptide|appos|START_ENTITY secretion|nmod|polypeptide secretion|nsubj|Suppression Suppression|nmod|release release|compound|END_ENTITY	Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide -LRB- GIP -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- .
10970071	0	VIP	45,48	growth_hormone	53,67	VIP	growth hormone	7432	2688	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- release and cell morphology in human pituitary_adenoma_cell_cultures .
2465985	0	VIP	202,205	pancreatic_polypeptide	220,242	VIP	pancreatic polypeptide	7432	5539	Gene	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
11597765	0	VIP	15,18	somatostatin	35,47	VIP	somatostatin	117064(Tax:10116)	24797(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Involvement of VIP on BDNF-induced somatostatin gene expression in cultured fetal rat cerebral cortical cells .
2881616	0	VIP	25,28	somatostatin	47,59	VIP	somatostatin	117064(Tax:10116)	24797(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	-LSB- Effect of forskolin and VIP on the release of somatostatin and the cAMP content of cultured rat diencephalon neurons -RSB- .
2465985	0	VIP	202,205	substance_P	207,218	VIP	substance P	7432	6863	Gene	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
356933	0	VIP	0,3	substance_P	19,30	VIP	substance P	22353(Tax:10090)	21333(Tax:10090)	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	VIP - , enkephalin - , substance_P - and somatostatin-like immunoreactivity in neurons intrinsic to the intestine : immunohistochemical evidence from organotypic tissue cultures .
2538330	0	VIP	101,104	vasoactive-intestinal-peptide	70,99	VIP	vasoactive-intestinal-peptide	7432	7432	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	A human melanoma-derived cell line -LRB- IGR39 -RRB- with a very high number of vasoactive-intestinal-peptide -LRB- VIP -RRB- receptors .
2538331	0	VIP	101,104	vasoactive-intestinal-peptide	70,99	VIP	vasoactive-intestinal-peptide	7432	7432	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	A human melanoma-derived cell line -LRB- IGR39 -RRB- with a very high number of vasoactive-intestinal-peptide -LRB- VIP -RRB- receptors .
19698755	0	VIP	54,57	vasoactive_intestinal_peptide	23,52	VIP	vasoactive intestinal peptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Adenoviral transfer of vasoactive_intestinal_peptide -LRB- VIP -RRB- gene inhibits rat aortic and pulmonary artery smooth muscle cell proliferation .
6786785	0	VIP	42,45	vasoactive_intestinal_peptide	11,40	VIP	vasoactive intestinal peptide	7432	7432	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of vasoactive_intestinal_peptide -LRB- VIP -RRB- on prolactin secretion in man -RSB- .
8063743	0	VIP	68,71	vasoactive_intestinal_peptide	37,66	VIP	vasoactive intestinal peptide	7432	7432	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transgenic_mice overexpressing human vasoactive_intestinal_peptide -LRB- VIP -RRB- gene in pancreatic beta cells .
10545014	0	VIP	49,52	vasoactive_intestinal_polypeptide	14,47	VIP	vasoactive intestinal polypeptide	22353(Tax:10090)	22353(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by vasoactive_intestinal_polypeptide -LRB- VIP -RRB- of angiogenesis induced by murine Colon 26-L5 carcinoma cells metastasized in liver .
10970071	0	VIP	45,48	vasoactive_intestinal_polypeptide	10,43	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- release and cell morphology in human pituitary_adenoma_cell_cultures .
11283411	0	VIP	67,70	vasoactive_intestinal_polypeptide	32,65	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and synaptology of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- immunoreactive structures in the rat periaqueductal grey .
15745085	0	VIP	54,57	vasoactive_intestinal_polypeptide	19,52	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Do elevated plasma vasoactive_intestinal_polypeptide -LRB- VIP -RRB- levels cause small intestinal motor disturbances in humans ?
1639036	0	VIP	60,63	vasoactive_intestinal_polypeptide	25,58	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Hypothyroidism increases vasoactive_intestinal_polypeptide -LRB- VIP -RRB- immunoreactivity and gene expression in the rat hypothalamic paraventricular nucleus .
1653848	0	VIP	51,54	vasoactive_intestinal_polypeptide	16,49	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- binding in circular muscle and characterization of VIP binding in canine small intestinal mucosa .
1687549	0	VIP	49,52	vasoactive_intestinal_polypeptide	14,47	VIP	vasoactive intestinal polypeptide	484038(Tax:9615)	484038(Tax:9615)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the canine_gallbladder motility .
2081700	0	VIP	46,49	vasoactive_intestinal_polypeptide	11,44	VIP	vasoactive intestinal polypeptide	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Changes in vasoactive_intestinal_polypeptide -LRB- VIP -RRB- levels in the rabbit oviduct at different hormonal stages .
215990	0	VIP	55,58	vasoactive_intestinal_polypeptide	20,53	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Cyclical release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- from a pancreatic islet cell apudoma .
2323384	0	VIP	49,52	vasoactive_intestinal_polypeptide	14,47	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat .
2380503	0	VIP	115,118	vasoactive_intestinal_polypeptide	80,113	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	Changes in adrenal neuropeptides content -LSB- peptide 7B2 , neuropeptide_Y -LRB- NPY -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- -RSB- induced by pharmacological and hormonal manipulations .
24395090	0	VIP	49,52	vasoactive_intestinal_polypeptide	14,47	VIP	vasoactive intestinal polypeptide	22353(Tax:10090)	22353(Tax:10090)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- induces resistance to dextran sodium_sulfate -LRB- DSS -RRB- - induced colitis in mice .
2546409	0	VIP	50,53	vasoactive_intestinal_polypeptide	15,48	VIP	vasoactive intestinal polypeptide	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on ocular_inflammation in rabbit ocular tissue -RSB- .
2666962	0	VIP	48,51	vasoactive_intestinal_polypeptide	13,46	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on splanchnic and central hemodynamics in healthy subjects .
3047320	0	VIP	70,73	vasoactive_intestinal_polypeptide	35,68	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunocytochemical localization of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in the brain of the little brown bat -LRB- Myotis lucifugus -RRB- .
3420301	0	VIP	45,48	vasoactive_intestinal_polypeptide	10,43	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on glucose and lipid metabolism of isolated rat adipocytes .
3562902	0	VIP	45,48	vasoactive_intestinal_polypeptide	10,43	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on steroidogenesis in women .
3891019	0	VIP	68,71	vasoactive_intestinal_polypeptide	33,66	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Selective facilitatory effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on muscarinic firing in vesical ganglia of the cat .
3911302	0	VIP	43,46	vasoactive_intestinal_polypeptide	8,41	VIP	vasoactive intestinal polypeptide	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in the neurogenic vasodilatation of the portal vein in the rabbit .
510498	0	VIP	46,49	vasoactive_intestinal_polypeptide	11,44	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A study of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- stimulated intestinal fluid secretion in rat and its inhibition by indomethacin .
594650	0	VIP	46,49	vasoactive_intestinal_polypeptide	11,44	VIP	vasoactive intestinal polypeptide	100500718	100500718	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- by intraduodenal stimuli .
6089138	0	VIP	43,46	vasoactive_intestinal_polypeptide	8,41	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in regulating the pituitary function in man .
6311891	0	VIP	47,50	vasoactive_intestinal_polypeptide	12,45	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- as a hypothalamic neurohormone .
6361235	0	VIP	46,49	vasoactive_intestinal_polypeptide	11,44	VIP	vasoactive intestinal polypeptide	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on renal function and plasma renin activity in the conscious rabbit .
6768592	0	VIP	46,49	vasoactive_intestinal_polypeptide	11,44	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in human prolactin -LRB- PRL -RRB- secreting pituitary_adenomas .
6889362	0	VIP	59,62	vasoactive_intestinal_polypeptide	24,57	VIP	vasoactive intestinal polypeptide	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Vasodilatory effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on isolated rat arteries .
7084506	0	VIP	45,48	vasoactive_intestinal_polypeptide	10,43	VIP	vasoactive intestinal polypeptide	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the in vitro and in vivo motility of the rabbit reproductive tract .
787988	0	VIP	51,54	vasoactive_intestinal_polypeptide	16,49	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- to central and peripheral neurons .
8119061	0	VIP	45,48	vasoactive_intestinal_polypeptide	10,43	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on pulmonary ventilation-perfusion relationships and central haemodynamics in healthy subjects .
830595	0	VIP	46,49	vasoactive_intestinal_polypeptide	11,44	VIP	vasoactive intestinal polypeptide	100500718	100500718	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- by electric stimulation of the vagal nerves .
8514821	0	VIP	46,49	vasoactive_intestinal_polypeptide	11,44	VIP	vasoactive intestinal polypeptide	280956(Tax:9913)	280956(Tax:9913)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the neuromuscular complex in the bovine ovarian follicle wall .
8593294	0	VIP	45,48	vasoactive_intestinal_polypeptide	10,43	VIP	vasoactive intestinal polypeptide	100145884(Tax:9940)	100145884(Tax:9940)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the net movement of electrolytes and water and glucose absorption in the jejunal loop of sheep .
8790778	0	VIP	55,58	vasoactive_intestinal_polypeptide	20,53	VIP	vasoactive intestinal polypeptide	7432	7432	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	The significance of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in immunomodulation .
8784267	0	VIP-R1	71,77	vasoactive_intestinal_peptide_receptor_1	29,69	VIP-R1	vasoactive intestinal peptide receptor 1	22354(Tax:10090)	22354(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Murine T-lymphocytes express vasoactive_intestinal_peptide_receptor_1 -LRB- VIP-R1 -RRB- mRNA .
25575489	0	VIPR2	151,156	VIP_receptor	137,149	VIPR2	VIP receptor	22355(Tax:10090)	22355(Tax:10090)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP_receptor -LRB- VIPR2 -RRB- agonist .
25575489	0	VIP_receptor	137,149	VIPR2	151,156	VIP receptor	VIPR2	22355(Tax:10090)	22355(Tax:10090)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP_receptor -LRB- VIPR2 -RRB- agonist .
10783149	0	VIP_receptor_subtype_2	15,37	IL-4	0,4	VIP receptor subtype 2	IL-4	22355(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-4 regulates VIP_receptor_subtype_2 mRNA -LRB- VPAC2 -RRB- expression in T cells in murine schistosomiasis .
10783149	0	VIP_receptor_subtype_2	15,37	VPAC2	44,49	VIP receptor subtype 2	VPAC2	22355(Tax:10090)	22355(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	IL-4 regulates VIP_receptor_subtype_2 mRNA -LRB- VPAC2 -RRB- expression in T cells in murine schistosomiasis .
19015334	0	VISA	136,140	hVISA	89,94	VISA	hVISA	57506	57506	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of inoculum size and heterogeneous vancomycin-intermediate Staphylococcus_aureus -LRB- hVISA -RRB- on vancomycin activity and emergence of VISA in an in vitro pharmacodynamic model .
25069408	0	VKORC1	55,61	CYP2C9	45,51	VKORC1	CYP2C9	79001	1559	Gene	Gene	*|nummod|START_ENTITY *|compound|END_ENTITY	Multiplex pyrosequencing method to determine CYP2C9 * 3 , VKORC1 * 2 , and CYP4F2 * 3 polymorphisms simultaneously : its application to a Korean population and comparisons with other ethnic groups .
18218987	0	VKORC1	47,53	Vitamin_K_epoxide_reductase_complex_subunit_1	0,45	VKORC1	Vitamin K epoxide reductase complex subunit 1	79001	79001	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Vitamin_K_epoxide_reductase_complex_subunit_1 -LRB- VKORC1 -RRB- polymorphism and aortic_calcification : the Rotterdam Study .
17059426	0	VKORC1	53,59	vitamin_K_epoxide_reductase_complex_subunit-1	6,51	VKORC1	vitamin K epoxide reductase complex subunit-1	79001	79001	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	A new vitamin_K_epoxide_reductase_complex_subunit-1 -LRB- VKORC1 -RRB- mutation in a patient with decreased stability of CYP2C9 enzyme .
8025956	0	VLA-1	19,24	CD49A	26,31	VLA-1	CD49A	3672	3672	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Functional role of VLA-1 -LRB- CD49A -RRB- in adhesion , cation-dependent spreading , and activation of cultured human T lymphocytes .
7594504	0	VLA-5	111,116	CD16	43,47	VLA-5	CD16	3678	2214	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of polymorphonuclear neutrophil CD16 and CD11b/CD18 expression by matrix proteins during hypoxia is VLA-5 , VLA-6 dependent .
10828007	0	VLA-5	62,67	CD34	86,90	VLA-5	CD34	3678	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	The chemokine SDF-1 activates the integrins LFA-1 , VLA-4 , and VLA-5 on immature human CD34 -LRB- + -RRB- cells : role in transendothelial/stromal migration and engraftment of NOD/SCID mice .
10836206	0	VLA-5	30,35	CD34	57,61	VLA-5	CD34	3678	947	Gene	Gene	adhesion|compound|START_ENTITY adhesion|nmod|cells cells|nummod|END_ENTITY	Interleukin-11 enhancement of VLA-5 mediated adhesion of CD34 + cells from cord blood to fibronectin is associated with the PI-3 kinase pathway .
7594504	0	VLA-5	111,116	VLA-6	118,123	VLA-5	VLA-6	3678	3655	Gene	Gene	START_ENTITY|dep|dependent dependent|amod|END_ENTITY	Regulation of polymorphonuclear neutrophil CD16 and CD11b/CD18 expression by matrix proteins during hypoxia is VLA-5 , VLA-6 dependent .
7594504	0	VLA-6	118,123	VLA-5	111,116	VLA-6	VLA-5	3655	3678	Gene	Gene	dependent|amod|START_ENTITY END_ENTITY|dep|dependent	Regulation of polymorphonuclear neutrophil CD16 and CD11b/CD18 expression by matrix proteins during hypoxia is VLA-5 , VLA-6 dependent .
15805543	0	VLDL	55,59	ACAT2	0,5	VLDL	ACAT2	54219(Tax:10090)	110460(Tax:10090)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	ACAT2 contributes cholesteryl_esters to newly secreted VLDL , whereas LCAT adds cholesteryl_ester to LDL in mice .
18367731	0	VLDL	22,26	vldlr	41,46	VLDL	vldlr	54219(Tax:10090)	22359(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	The hepatic uptake of VLDL in lrp-ldlr - / - vldlr - / - mice is regulated by LPL activity and involves proteoglycans and SR-BI .
24058663	0	VLDLR	20,25	LRP5	12,16	VLDLR	LRP5	22359(Tax:10090)	16973(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Deletion of LRP5 in VLDLR knockout mice inhibits_retinal_neovascularization .
24293365	0	VLDLR	39,44	Very_low_density_lipoprotein_receptor	0,37	VLDLR	Very low density lipoprotein receptor	22359(Tax:10090)	22359(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Very_low_density_lipoprotein_receptor -LRB- VLDLR -RRB- expression is a determinant factor in adipose tissue inflammation and adipocyte-macrophage interaction .
11501949	0	VLDLR	78,83	very_low_density_lipoprotein_receptor	39,76	VLDLR	very low density lipoprotein receptor	7436	7436	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphisms of the very_low_density_lipoprotein_receptor -LRB- VLDLR -RRB- gene .
15863833	0	VLDL_receptor	43,56	apoE	4,8	VLDL receptor	apoE	7436	348	Gene	Gene	properties|nmod|START_ENTITY properties|amod|END_ENTITY	The apoE isoform binding properties of the VLDL_receptor reveal marked differences from LRP and the LDL_receptor .
15671307	0	VLGR1	47,52	USH2C	68,73	VLGR1	USH2C	84059	84059	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Disease expression in Usher_syndrome caused by VLGR1 gene mutation -LRB- USH2C -RRB- and comparison with USH2A phenotype .
17134514	0	VMAT1	60,65	vesicular_monoamine_transporter_1	25,58	VMAT1	vesicular monoamine transporter 1	6570	6570	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association study of the vesicular_monoamine_transporter_1 -LRB- VMAT1 -RRB- gene with schizophrenia in a Japanese population .
25496994	0	VMAT2	18,23	JNK	0,3	VMAT2	JNK	6571	5599	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron_death .
18041582	0	VMAT2	114,119	vesicular_monoamine_transporter_2	79,112	VMAT2	vesicular monoamine transporter 2	214084(Tax:10090)	214084(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A metabolomic study of brain tissues from aged mice with low expression of the vesicular_monoamine_transporter_2 -LRB- VMAT2 -RRB- gene .
23404442	0	VMAT2	52,57	vesicular_monoamine_transporter_2	17,50	VMAT2	vesicular monoamine transporter 2	6571	6571	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Species-specific vesicular_monoamine_transporter_2 -LRB- VMAT2 -RRB- expression in mammalian pancreatic beta cells : implications for optimising radioligand-based human beta_cell_mass -LRB- BCM -RRB- imaging in animal models .
21291984	0	VMAT_2	70,76	DAT	77,80	VMAT 2	DAT	25549(Tax:10116)	24898(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Protective effect of Zhen-Wu-Tang -LRB- ZWT -RRB- through keeping DA stable and VMAT_2 / DAT mRNA in balance in rats with striatal lesions induced by MPTP .
15367889	0	VMP1	42,46	vacuole_membrane_protein_1	14,40	VMP1	vacuole membrane protein 1	192129(Tax:10116)	192129(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vacuole_membrane_protein_1 -LRB- VMP1 -RRB- in spontaneous chronic_pancreatitis in the WBN/Kob rat .
20723363	0	VP-16	63,68	GRP78	20,25	VP-16	GRP78	3054	3309	Gene	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|compound|END_ENTITY	-LSB- Down-regulation of GRP78 Enhances Chemotherapy Sensitivity to VP-16 in Lung_Adenocarcinoma . -RSB- .
26314433	0	VP-16	73,78	MiR-18a	1,8	VP-16	MiR-18a	3054	406953	Gene	Gene	Regulate|nmod|START_ENTITY Regulate|nsubj|END_ENTITY	-LSB- MiR-18a Can Regulate Chemotherapy Sensitivity of Leukemia Cell HL-60 to VP-16 and VCR by Targeting ATM -RSB- .
23416977	0	VP-16	67,72	Star-PAP	0,8	VP-16	Star-PAP	3054	64852	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16 .
21826248	0	VP1	12,15	Akt	20,23	VP1	Akt	65130(Tax:10116)	11651(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Recombinant VP1 , an Akt inhibitor , suppresses progression of hepatocellular_carcinoma by inducing apoptosis and modulation of CCL2 production .
22983836	0	VP1	26,29	HER-2	41,46	VP1	HER-2	65130(Tax:10116)	2064	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast_cancer .
1373202	0	VP1	168,171	NS2	113,116	VP1	NS2	1489592(Tax:10794)	57762	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The pathogenesis of infection with minute_virus_of_mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2 .
8586889	0	VP1	60,63	VP2	66,69	VP1	VP2	1489598(Tax:10798)	11293627	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Seroepidemiology of human_parvovirus_B19 using recombinant VP1 + VP2 particle antigen -RSB- .
22388104	0	VP1	33,36	prohibitin	125,135	VP1	prohibitin	65130(Tax:10116)	5245	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|modulating modulating|dobj|END_ENTITY	Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical_cancer by modulating phosphorylated prohibitin in lipid rafts .
15284487	0	VP16	91,95	BPLF1	18,23	VP16	BPLF1	3054	3783726(Tax:10376)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|dep|homologue	The reading frame BPLF1 of Epstein-Barr_virus : a homologue of herpes simplex virus protein VP16 .
15793239	0	VP16	6,10	PDX-1	0,5	VP16	PDX-1	3054	3651	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|appos|induces	PDX-1 / VP16 fusion protein , together with NeuroD or Ngn3 , markedly induces insulin gene transcription and ameliorates glucose tolerance .
10623756	0	VP16	73,77	luman	19,24	VP16	luman	3054	10488	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Potential role for luman , the cellular homologue of herpes_simplex_virus VP16 -LRB- alpha gene trans-inducing factor -RRB- , in herpesvirus latency .
18479065	0	VP2	75,78	CTLA-4	61,67	VP2	CTLA-4	1489588(Tax:10788)	12477(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	-LSB- Immunoadjuvant effect of the extracellular domain of canine CTLA-4 on the VP2 protein of canine_parvovirus -RSB- .
8586889	0	VP2	66,69	VP1	60,63	VP2	VP1	11293627	1489598(Tax:10798)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Seroepidemiology of human_parvovirus_B19 using recombinant VP1 + VP2 particle antigen -RSB- .
24630991	0	VP24	18,22	Keap1	46,51	VP24	Keap1	911828(Tax:186538)	9817	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway .
21987769	0	VP35	35,39	DRBP76	0,6	VP35	DRBP76	911827(Tax:186538)	3609	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function .
24606036	0	VPA0450	124,131	VPA0451	18,25	VPA0450	VPA0451	1191138(Tax:223926)	1191139(Tax:223926)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of VPA0451 as the specific chaperone for the Vibrio_parahaemolyticus chromosome 1 type III-secreted effector VPA0450 .
24606036	0	VPA0451	18,25	VPA0450	124,131	VPA0451	VPA0450	1191139(Tax:223926)	1191138(Tax:223926)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of VPA0451 as the specific chaperone for the Vibrio_parahaemolyticus chromosome 1 type III-secreted effector VPA0450 .
18534815	0	VPAC-1	79,85	CD4	115,118	VPAC-1	CD4	22354(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	TCR signaling and environment affect vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- expression in primary mouse CD4 T cells .
18555660	0	VPAC-1	100,106	CD4	125,128	VPAC-1	CD4	22354(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Stimulatory and suppressive signal transduction regulates vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- in primary mouse CD4 T cells .
18534815	0	VPAC-1	79,85	vasoactive_intestinal_peptide_receptor-1	37,77	VPAC-1	vasoactive intestinal peptide receptor-1	22354(Tax:10090)	22354(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TCR signaling and environment affect vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- expression in primary mouse CD4 T cells .
14744818	0	VPAC1	14,19	VIP	33,36	VPAC1	VIP	7433	7432	Gene	Gene	receptors|nummod|START_ENTITY receptors|nmod|END_ENTITY	Activation of VPAC1 receptors by VIP and PACAP-27 in human bronchial epithelial cells induces CFTR-dependent chloride secretion .
25066643	0	VPAC1_receptor	109,123	pituitary_adenylate_cyclase-activating_polypeptide	40,90	VPAC1 receptor	pituitary adenylate cyclase-activating polypeptide	7433	116	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Augmented cystine-glutamate exchange by pituitary_adenylate_cyclase-activating_polypeptide signaling via the VPAC1_receptor .
10783149	0	VPAC2	44,49	VIP_receptor_subtype_2	15,37	VPAC2	VIP receptor subtype 2	22355(Tax:10090)	22355(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	IL-4 regulates VIP_receptor_subtype_2 mRNA -LRB- VPAC2 -RRB- expression in T cells in murine schistosomiasis .
11514016	0	VPAC2	66,71	extracellular_loop	34,52	VPAC2	extracellular loop	7434	6939	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Proline residue 280 in the second extracellular_loop -LRB- EC2 -RRB- of the VPAC2 receptor is essential for the receptor structure .
19533689	0	VPS13B	17,23	COH1	25,29	VPS13B	COH1	157680	157680	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Deletions in the VPS13B -LRB- COH1 -RRB- gene as a cause of Cohen_syndrome .
16857164	0	VPS22	24,29	RILP	0,4	VPS22	RILP	11267	83547	Gene	Gene	component|compound|START_ENTITY interacts|nmod|component interacts|nsubj|END_ENTITY	RILP interacts with the VPS22 component of the ESCRT-II complex .
17010938	0	VPS22	20,25	RILP	0,4	VPS22	RILP	11267	83547	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment .
25565814	0	VPS34	115,120	Bcl-2	109,114	VPS34	Bcl-2	5289	596	Gene	Gene	complex|compound|START_ENTITY complex|dep|END_ENTITY	Ferroferric_oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin_1 / Bcl-2 / VPS34 complex .
25565814	0	VPS34	115,120	Beclin_1	100,108	VPS34	Beclin 1	5289	8678	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Ferroferric_oxide nanoparticles induce prosurvival autophagy in human blood cells by modulating the Beclin_1 / Bcl-2 / VPS34 complex .
26300542	0	VPS35	22,27	EIF4G1	60,66	VPS35	EIF4G1	55737	1981	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population .
11112353	0	VPS35	38,43	VPS35	75,80	VPS35	VPS35	55737	65114(Tax:10090)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21 .
11112353	0	VPS35	75,80	VPS35	38,43	VPS35	VPS35	65114(Tax:10090)	55737	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21 .
24077878	0	VPS4B	55,60	vacuolar_protein_sorting_4B	26,53	VPS4B	vacuolar protein sorting 4B	360834(Tax:10116)	360834(Tax:10116)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	The expression changes of vacuolar_protein_sorting_4B -LRB- VPS4B -RRB- following middle_cerebral_artery_occlusion -LRB- MCAO -RRB- in adult rats brain hippocampus .
21187289	0	VPS9-ankyrin-repeat_protein	31,58	Varp	60,64	VPS9-ankyrin-repeat protein	Varp	84079	84079	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Structure-function analysis of VPS9-ankyrin-repeat_protein -LRB- Varp -RRB- in the trafficking of tyrosinase-related_protein_1 in melanocytes .
23517865	0	VR-1	60,64	p38	45,48	VR-1	p38	83810(Tax:10116)	81649(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Intervention of electroacupuncture on spinal p38 MAPK/ATF -2 / VR-1 pathway in treating inflammatory_pain induced by CFA in rats .
11825677	0	VR1	34,37	capsaicin_receptor	14,32	VR1	capsaicin receptor	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of capsaicin_receptor -LRB- VR1 -RRB- by myelinated primary afferent neurons in rats .
12906843	0	VR1	50,53	substance_P_and_vanilloid_receptor	14,48	VR1	substance P and vanilloid receptor	193034(Tax:10090)	21336(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of substance_P_and_vanilloid_receptor -LRB- VR1 -RRB- in trigeminal sensory neurons projecting to the mouse nasal mucosa .
12926020	0	VR1	40,43	vanilloid_receptor	20,38	VR1	vanilloid receptor	7442	7442	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of the vanilloid_receptor -LRB- VR1 -RRB- in the gastrointestinal tract .
14514756	0	VR1	36,39	vanilloid_receptor_1	14,34	VR1	vanilloid receptor 1	7442	7442	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of vanilloid_receptor_1 -LRB- VR1 -RRB- by eugenol .
16199552	0	VR22	46,50	alpha-T_catenin	24,39	VR22	alpha-T catenin	29119	29119	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interaction between the alpha-T_catenin gene -LRB- VR22 -RRB- and APOE in Alzheimer 's _ disease .
10951572	0	VRK1	37,41	p53	108,111	VRK1	p53	7443	7157	Gene	Gene	vaccinia-related_kinase_1|appos|START_ENTITY phosphorylates|nsubj|vaccinia-related_kinase_1 phosphorylates|xcomp|threonine-18 threonine-18|nmod|site site|nmod|protein protein|compound|END_ENTITY	The human vaccinia-related_kinase_1 -LRB- VRK1 -RRB- phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein .
18612383	0	VRK1	47,51	p53	98,101	VRK1	p53	7443	7157	Gene	Gene	protect|dobj|START_ENTITY protect|nmod|downregulation downregulation|acl|induced induced|nmod|END_ENTITY	The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53 .
24492002	0	VRK1	0,4	p53	20,23	VRK1	p53	7443	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage .
16963744	0	VRK2	23,27	BHRF1	75,80	VRK2	BHRF1	7444	3783706(Tax:10376)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human cellular protein VRK2 interacts specifically with Epstein-Barr_virus BHRF1 , a homologue of Bcl-2 , and enhances cell survival .
15174083	0	VRL1	27,31	Vanilloid_receptor_like_1	0,25	VRL1	Vanilloid receptor like 1	51393	51393	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	Vanilloid_receptor_like_1 -LRB- VRL1 -RRB- immunoreactivity in mammalian retina : colocalization with somatostatin and purinergic P2X1 receptors .
26683098	0	VSNL1	43,48	CDR1	36,40	VSNL1	CDR1	7447	1038	Gene	Gene	axis|compound|START_ENTITY involved|nsubjpass|axis END_ENTITY|parataxis|involved	Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma_multiforme .
23424245	0	VTC1	33,37	CSN5B	12,17	VTC1	CSN5B	818562(Tax:3702)	843463(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic_acid synthesis .
24347572	0	VTCN1	21,26	B7-H4	28,33	VTCN1	B7-H4	79679	79679	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic variation in VTCN1 -LRB- B7-H4 -RRB- is associated with course of disease in juvenile_idiopathic_arthritis .
23523902	0	VWA1	15,19	matrilin-3	4,14	VWA1	matrilin-3	64856	4148	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	The matrilin-3 VWA1 domain modulates interleukin-6 release from primary human chondrocytes .
18434322	0	VWA2	123,127	AMACO	116,121	VWA2	AMACO	340706	340706	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO -LRB- VWA2 protein -RRB- .
19861176	0	VWA2	25,29	AMACO	18,23	VWA2	AMACO	567428(Tax:7955)	567428(Tax:7955)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Expression of the AMACO -LRB- VWA2 protein -RRB- ortholog in zebrafish .
16204318	0	VWF	118,121	ADAMTS13	139,147	VWF	ADAMTS13	22371(Tax:10090)	279028(Tax:10090)	Gene	Gene	protecting|dobj|START_ENTITY protecting|nmod|END_ENTITY	Thrombospondin-1 controls vascular platelet recruitment and thrombus adherence in mice by protecting -LRB- sub -RRB- endothelial VWF from cleavage by ADAMTS13 .
17975018	0	VWF	26,29	ADAMTS13	61,69	VWF	ADAMTS13	7450	11093	Gene	Gene	glycosylation|nmod|START_ENTITY modulates|nsubj|glycosylation modulates|nmod|END_ENTITY	N-linked glycosylation of VWF modulates its interaction with ADAMTS13 .
19587373	0	VWF	84,87	ADAMTS13	25,33	VWF	ADAMTS13	7450	11093	Gene	Gene	surface|nmod|START_ENTITY exposed|nmod|surface exposed|nsubj|site site|nmod|END_ENTITY	A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF .
20032502	0	VWF	142,145	ADAMTS13	72,80	VWF	ADAMTS13	7450	11093	Gene	Gene	site|nmod|START_ENTITY identifies|dobj|site identifies|nsubj|epitope epitope|acl|comprising comprising|advcl|residues residues|nmod|domain domain|compound|END_ENTITY	An autoantibody epitope comprising residues R660 , Y661 , and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF .
20695979	0	VWF	98,101	ADAMTS13	45,53	VWF	ADAMTS13	22371(Tax:10090)	279028(Tax:10090)	Gene	Gene	strings|compound|START_ENTITY proteolysis|nmod|strings proteolysis|compound|END_ENTITY	The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo .
22070827	0	VWF	40,43	ADAMTS13	7,15	VWF	ADAMTS13	7450	11093	Gene	Gene	factor|appos|START_ENTITY END_ENTITY|appos|factor	Plasma ADAMTS13 , von_Willebrand factor -LRB- VWF -RRB- and VWF propeptide profiles in patients with DIC and related_diseases .
22323407	0	VWF	5,8	ADAMTS13	14,22	VWF	ADAMTS13	7450	11093	Gene	Gene	puts|nsubj|START_ENTITY puts|nsubj|END_ENTITY	High VWF , low ADAMTS13 puts women at risk .
25564400	0	VWF	49,52	ADAMTS13	16,24	VWF	ADAMTS13	7450	11093	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis .
26345337	0	VWF	108,111	ADAMTS13	115,123	VWF	ADAMTS13	7450	11093	Gene	Gene	type|nmod|START_ENTITY type|nmod|END_ENTITY	The co-influence of VWD type 2B/2M mutations in the A1 domain and platelet GPIba on the rate of cleavage to VWF by ADAMTS13 .
26345337	0	VWF	108,111	ADAMTS13	115,123	VWF	ADAMTS13	7450	11093	Gene	Gene	type|nmod|START_ENTITY type|nmod|END_ENTITY	The co-influence of VWD type 2B/2M mutations in the A1 domain and platelet GPIba on the rate of cleavage to VWF by ADAMTS13 .
26759371	0	VWF	40,43	ADAMTS13	7,15	VWF	ADAMTS13	7450	11093	Gene	Gene	von_Willebrand_Factor|appos|START_ENTITY END_ENTITY|appos|von_Willebrand_Factor	Plasma ADAMTS13 , von_Willebrand_Factor -LRB- VWF -RRB- , and VWF Propeptide Profiles in Patients With Connective Tissue Diseases and Antiphospholipid_Syndrome .
12969981	0	VWF	107,110	FVIII	32,37	VWF	FVIII	7450	2157	Gene	Gene	binding|nmod|START_ENTITY impairing|xcomp|binding results|advcl|impairing results|nsubj|Deletion Deletion|nmod|alanine_2201 alanine_2201|nmod|domain domain|compound|END_ENTITY	Deletion of alanine_2201 in the FVIII C2 domain results in mild hemophilia_A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development .
12969981	0	VWF	107,110	FVIII	90,95	VWF	FVIII	7450	2157	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Deletion of alanine_2201 in the FVIII C2 domain results in mild hemophilia_A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development .
16985172	0	VWF	0,3	FVIII	13,18	VWF	FVIII	7450	2157	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors .
18549909	0	VWF	12,15	FVIII	41,46	VWF	FVIII	7450	2157	Gene	Gene	role|nmod|START_ENTITY role|nmod|immunogenicity immunogenicity|nmod|END_ENTITY	The role of VWF in the immunogenicity of FVIII .
21699629	0	VWF	105,108	FVIII	62,67	VWF	FVIII	7450	2157	Gene	Gene	experience|appos|START_ENTITY experience|nmod|Optivate Optivate|appos|END_ENTITY	Clinical experience with Optivate , high-purity factor_VIII -LRB- FVIII -RRB- product with von_Willebrand factor -LRB- VWF -RRB- in young children with haemophilia_A .
21725579	0	VWF	60,63	FVIII	79,84	VWF	FVIII	7450	2157	Gene	Gene	factor|appos|START_ENTITY diversity|nmod|factor diversity|parataxis|concentrates concentrates|nsubj|factor_VIII factor_VIII|appos|END_ENTITY	The pharmacokinetic diversity of two von_Willebrand factor -LRB- VWF -RRB- / factor_VIII -LRB- FVIII -RRB- concentrates in subjects with congenital_von_Willebrand_disease .
21726357	0	VWF	55,58	FVIII	59,64	VWF	FVIII	100009165(Tax:9986)	2157	Gene	Gene	impact|nmod|START_ENTITY infusions|dep|impact infusions|dep|ratio ratio|nummod|END_ENTITY	Repeated infusions of VWF/FVIII concentrate : impact of VWF : FVIII ratio on FVIII trough and peak levels in a rabbit model .
21726357	0	VWF	55,58	FVIII	74,79	VWF	FVIII	100009165(Tax:9986)	2157	Gene	Gene	impact|nmod|START_ENTITY infusions|dep|impact infusions|dep|ratio ratio|nmod|trough trough|compound|END_ENTITY	Repeated infusions of VWF/FVIII concentrate : impact of VWF : FVIII ratio on FVIII trough and peak levels in a rabbit model .
25035147	0	VWF	21,24	FVIII	0,5	VWF	FVIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	D'D3|compound|START_ENTITY do|nsubj|D'D3 stabilization|parataxis|do stabilization|compound|END_ENTITY	FVIII stabilization : VWF D'D3 will do .
25767894	0	VWF	18,21	FVIII	23,28	VWF	FVIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	Utility|nmod|START_ENTITY Utility|dep|ratio ratio|nummod|END_ENTITY	Utility of a high VWF : FVIII ratio in preventing FVIII accumulation : a study in VWF-deficient mice .
25767894	0	VWF	18,21	FVIII	49,54	VWF	FVIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	Utility|nmod|START_ENTITY Utility|dep|ratio ratio|nmod|accumulation accumulation|compound|END_ENTITY	Utility of a high VWF : FVIII ratio in preventing FVIII accumulation : a study in VWF-deficient mice .
25905473	0	VWF	62,65	FVIII	78,83	VWF	FVIII	22371(Tax:10090)	2157	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes .
7674090	0	VWF	0,3	TNF_alpha	76,85	VWF	TNF alpha	7450	7124	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	VWF release and platelet_aggregation in human melanoma after perfusion with TNF_alpha .
21699629	0	VWF	105,108	factor_VIII	49,60	VWF	factor VIII	7450	2157	Gene	Gene	experience|appos|START_ENTITY experience|nmod|Optivate Optivate|appos|END_ENTITY	Clinical experience with Optivate , high-purity factor_VIII -LRB- FVIII -RRB- product with von_Willebrand factor -LRB- VWF -RRB- in young children with haemophilia_A .
12649145	0	VWF	63,66	interleukin-11	75,89	VWF	interleukin-11	399544(Tax:9615)	611309(Tax:9615)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin -LRB- DDAVP -RRB- .
23690449	0	VWF	39,42	von_Willebrand_factor	16,37	VWF	von Willebrand factor	7450	7450	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Common and rare von_Willebrand_factor -LRB- VWF -RRB- coding variants , VWF levels , and factor_VIII levels in African Americans : the NHLBI Exome Sequencing Project .
14962303	0	VWF-cleaving_protease	21,42	ADAMTS13	44,52	VWF-cleaving protease	ADAMTS13	11093	11093	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Severe deficiency of VWF-cleaving_protease -LRB- ADAMTS13 -RRB- activity defines a distinct population of thrombotic_microangiopathy patients .
15224369	0	VWF_cleaving_protease	21,42	ADAMTS13	44,52	VWF cleaving protease	ADAMTS13	11093	11093	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Simplified assay for VWF_cleaving_protease -LRB- ADAMTS13 -RRB- activity and inhibitor in plasma .
11889142	0	Vac14p	82,88	Fab1p	123,128	Vac14p	Fab1p	851102(Tax:4932)	850574(Tax:4932)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Osmotic stress-induced increase of phosphatidylinositol_3 ,5 - bisphosphate requires Vac14p , an activator of the lipid kinase Fab1p .
20876349	0	Valosin-containing_protein	0,26	granzyme_K	39,49	Valosin-containing protein	granzyme K	7415	3003	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Valosin-containing_protein cleavage by granzyme_K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target_tumor cells .
23018179	0	Valosin_containing_protein	0,26	PTPL1	95,100	Valosin containing protein	PTPL1	269523(Tax:10090)	19249(Tax:10090)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Valosin_containing_protein -LRB- VCP/p97 -RRB- is a novel substrate for the protein tyrosine phosphatase PTPL1 .
10384104	0	Valpha14	20,28	CD4	29,32	Valpha14	Th2	111622(Tax:10090)	15111(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	A novel function of Valpha14 + CD4 + NKT cells : stimulation of IL-12 production by antigen-presenting cells in the innate immune system .
12671739	0	Valpha14	40,48	TRAV11	32,38	Valpha14	TRAV11	111622(Tax:10090)	100126466(Tax:10090)	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	Surprisingly minor influence of TRAV11 -LRB- Valpha14 -RRB- polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics .
16410243	0	Vangl1	0,6	intestinal_trefoil_factor	48,73	Vangl1	intestinal trefoil factor	81839	7033	Gene	Gene	acts|amod|START_ENTITY acts|nmod|END_ENTITY	Vangl1 protein acts as a downstream effector of intestinal_trefoil_factor -LRB- ITF -RRB- / TFF3 signaling and regulates wound healing of intestinal epithelium .
25373475	0	Vangl2	0,6	E-cadherin	17,27	Vangl2	E-cadherin	93840(Tax:10090)	12550(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Vangl2 regulates E-cadherin in epithelial cells .
15174083	0	Vanilloid_receptor_like_1	0,25	VRL1	27,31	Vanilloid receptor like 1	VRL1	51393	51393	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Vanilloid_receptor_like_1 -LRB- VRL1 -RRB- immunoreactivity in mammalian retina : colocalization with somatostatin and purinergic P2X1 receptors .
16525121	0	Varp	0,4	Rab21	10,15	Varp	Rab21	84079	23011	Gene	Gene	factor|nsubj|START_ENTITY factor|amod|END_ENTITY	Varp is a Rab21 guanine_nucleotide exchange factor and regulates endosome dynamics .
18477474	0	Varp	0,4	Rab38	20,25	Varp	Rab38	84079	23682	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Varp interacts with Rab38 and functions as its potential effector .
21187289	0	Varp	60,64	VPS9-ankyrin-repeat_protein	31,58	Varp	VPS9-ankyrin-repeat protein	84079	84079	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Structure-function analysis of VPS9-ankyrin-repeat_protein -LRB- Varp -RRB- in the trafficking of tyrosinase-related_protein_1 in melanocytes .
24147211	0	Vascular_Cell_Adhesion_Molecule_1	31,64	Integrin_Alpha_4	76,92	Vascular Cell Adhesion Molecule 1	Integrin Alpha 4	22329(Tax:10090)	16401(Tax:10090)	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	Amino_Acid Sequences Mediating Vascular_Cell_Adhesion_Molecule_1 Binding to Integrin_Alpha_4 : Homologous DSP Sequence Found for JC Polyoma VP1 Coat Protein .
12058196	0	Vascular_Endothelial_Cell_Growth_Inhibitor	66,108	VEGI	47,51	Vascular Endothelial Cell Growth Inhibitor	VEGI	9966	9966	Gene	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	Cloning , Expression and Biological Activity of VEGI -LRB- 151 -RRB- , a Novel Vascular_Endothelial_Cell_Growth_Inhibitor .
25012178	0	Vascular_Endothelial_Growth_Factor	17,51	Akt	65,68	Vascular Endothelial Growth Factor	Akt	7422	207	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|Signaling Signaling|compound|END_ENTITY	GIV/Girdin Links Vascular_Endothelial_Growth_Factor Signaling to Akt Survival Signaling in Podocytes Independent of Nephrin .
26350463	0	Vascular_Endothelial_Growth_Factor	58,92	Corticotropin_Releasing_Hormone	0,31	Vascular Endothelial Growth Factor	Corticotropin Releasing Hormone	7422	1392	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|dobj|Expression	Corticotropin_Releasing_Hormone and Urocortin_3 Stimulate Vascular_Endothelial_Growth_Factor Expression through the cAMP/CREB Pathway .
24871583	0	Vascular_Endothelial_Growth_Factor	106,140	Endocan	25,32	Vascular Endothelial Growth Factor	Endocan	7422	11082	Gene	Gene	Upregulated|nmod|START_ENTITY Upregulated|nsubjpass|END_ENTITY	The Angiogenic Biomarker Endocan is Upregulated in Proliferative Diabetic_Retinopathy and Correlates with Vascular_Endothelial_Growth_Factor .
25674742	0	Vascular_Endothelial_Growth_Factor	25,59	Metadherin	0,10	Vascular Endothelial Growth Factor	Metadherin	7422	92140	Gene	Gene	Expression|compound|START_ENTITY Regulation|nmod|Expression Regulation|compound|END_ENTITY	Metadherin Regulation of Vascular_Endothelial_Growth_Factor Expression Is Dependent Upon the PI3K/Akt Pathway in Squamous_Cell_Carcinoma of the Head_and_Neck .
25012178	0	Vascular_Endothelial_Growth_Factor	17,51	Nephrin	116,123	Vascular Endothelial Growth Factor	Nephrin	7422	4868	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	GIV/Girdin Links Vascular_Endothelial_Growth_Factor Signaling to Akt Survival Signaling in Podocytes Independent of Nephrin .
26991001	0	Vascular_Endothelial_Growth_Factor	80,114	Neuropilin-2	22,34	Vascular Endothelial Growth Factor	Neuropilin-2	7422	8828	Gene	Gene	Pocket|compound|START_ENTITY Away|nmod|Pocket Reveal|advmod|Away Reveal|nsubj|Studies Studies|nmod|END_ENTITY	Structural Studies of Neuropilin-2 Reveal a Zinc Ion Binding Site Away from the Vascular_Endothelial_Growth_Factor Binding Pocket .
22110141	0	Vascular_Endothelial_Growth_Factor	30,64	Osterix	116,123	Vascular Endothelial Growth Factor	Osterix	22339(Tax:10090)	170574(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- by osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- in osteoblasts .
20076865	0	Vascular_Endothelial_Growth_Factor	49,83	P53	35,38	Vascular Endothelial Growth Factor	P53	7422	7157	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	Immunohistochemical evaluation for P53 and VEGF -LRB- Vascular_Endothelial_Growth_Factor -RRB- is not prognostic for long term survival in end stage esophageal_adenocarcinoma .
26529476	0	Vascular_Endothelial_Growth_Factor	0,34	Placental_Growth_Factor	35,58	Vascular Endothelial Growth Factor	Placental Growth Factor	7422	5228	Gene	Gene	START_ENTITY|dep|Levels Levels|compound|END_ENTITY	Vascular_Endothelial_Growth_Factor / Placental_Growth_Factor Heterodimer Levels in Preterm Infants with Bronchopulmonary_Dysplasia .
22110141	0	Vascular_Endothelial_Growth_Factor	30,64	VEGF	66,70	Vascular Endothelial Growth Factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- by osteoblast-specific transcription factor Osterix -LRB- Osx -RRB- in osteoblasts .
23756839	0	Vascular_Endothelial_Growth_Factor	14,48	VEGF	50,54	Vascular Endothelial Growth Factor	VEGF	7422	7422	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- mRNA in healthy bone tissue around implants and in peri-implantitis .
24171833	0	Vascular_Endothelial_Growth_Factor	14,48	VEGF	50,54	Vascular Endothelial Growth Factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- in Macrophages , Fibroblasts , and Endothelial Cells in Pterygium Treated with 5-Fluorouracil .
26083024	0	Vascular_Endothelial_Growth_Factor	55,89	VEGF	91,95	Vascular Endothelial Growth Factor	VEGF	7422	7422	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	A Systematic Review and Meta-Analysis on the Safety of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- Inhibitors for the Treatment of Retinopathy_of_Prematurity .
25778658	0	Vascular_Endothelial_Growth_Factor	14,48	VEGF-A	50,56	Vascular Endothelial Growth Factor	VEGF-A	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Vascular_Endothelial_Growth_Factor -LRB- VEGF-A -RRB- in Rat Mandibular Salivary Gland during Paraneoplastic Process and Treatment with Cyclophosphamide and Melatonin .
26154255	0	Vascular_Endothelial_Growth_Factor	51,85	VEGFR-2	93,100	Vascular Endothelial Growth Factor	VEGFR-2	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	START_ENTITY|dep|Signaling Signaling|compound|END_ENTITY	Geraniol Suppresses Angiogenesis by Downregulating Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- / VEGFR-2 Signaling .
25050010	0	Vascular_Endothelial_Growth_Factor_Alpha	61,101	VEGFa	103,108	Vascular Endothelial Growth Factor Alpha	VEGFa	100033839(Tax:9796)	100033839(Tax:9796)	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Molecular Characterization and Expression Analysis of Equine Vascular_Endothelial_Growth_Factor_Alpha -LRB- VEGFa -RRB- Gene in Horse -LRB- Equus_caballus -RRB- .
19520742	0	Vascular_cell_adhesion_molecule-1	0,33	NF-kappaB	134,143	Vascular cell adhesion molecule-1	NF-kappaB	7412	4790	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Vascular_cell_adhesion_molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK / NF-kappaB : inhibitory role of curcumin .
1280699	0	Vascular_cell_adhesion_molecule-1	0,33	VCAM-1	35,41	Vascular cell adhesion molecule-1	VCAM-1	22329(Tax:10090)	22329(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in murine lupus_nephritis .
7691889	0	Vascular_cell_adhesion_molecule-1	0,33	VCAM-1	35,41	Vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells .
15265790	0	Vascular_cell_adhesion_molecule_1	0,33	VCAM-1	35,41	Vascular cell adhesion molecule 1	VCAM-1	7412	7412	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- activation of endothelial cell matrix metalloproteinases : role of reactive oxygen species .
9663488	0	Vascular_cell_adhesion_molecule_1	0,33	intercellular_adhesion_molecule_1	152,185	Vascular cell adhesion molecule 1	intercellular adhesion molecule 1	7412	3383	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|expression expression|nmod|END_ENTITY	Vascular_cell_adhesion_molecule_1 -LRB- CD106 -RRB- on primary human articular chondrocytes : functional regulation of expression by cytokines and comparison with intercellular_adhesion_molecule_1 -LRB- CD54 -RRB- and very late activation antigen 2 .
20856927	0	Vascular_cellular_adhesion_molecule-1	0,37	VCAM-1	39,45	Vascular cellular adhesion molecule-1	VCAM-1	22329(Tax:10090)	22329(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_cellular_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia .
23331867	0	Vascular_endothelial-cadherin	0,29	insulin-like_growth_factor-1_receptor	60,97	Vascular endothelial-cadherin	insulin-like growth factor-1 receptor	12562(Tax:10090)	16001(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|END_ENTITY	Vascular_endothelial-cadherin stimulates syndecan-1-coupled insulin-like_growth_factor-1_receptor and cross-talk between aVb3 integrin and vascular_endothelial_growth_factor_receptor_2 at the onset of endothelial cell dissemination during angiogenesis .
16936124	0	Vascular_endothelial_growth_factor	0,34	ADAMTS1	61,68	Vascular endothelial growth factor	ADAMTS1	22339(Tax:10090)	11504(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor upregulates expression of ADAMTS1 in endothelial cells through protein kinase C signaling .
11461089	0	Vascular_endothelial_growth_factor	0,34	BCL-2	54,59	Vascular endothelial growth factor	BCL-2	7422	596	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|apoptosis apoptosis|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- upregulates BCL-2 and inhibits apoptosis in human and murine mammary adenocarcinoma cells .
15609132	0	Vascular_endothelial_growth_factor	0,34	BRCA1	69,74	Vascular endothelial growth factor	BRCA1	7422	672	Gene	Gene	START_ENTITY|dep|levels levels|nmod|gene gene|compound|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels and mutation of the BRCA1 gene in breast_cancer patients .
9582377	0	Vascular_endothelial_growth_factor	0,34	Bcl-2	84,89	Vascular endothelial growth factor	Bcl-2	7422	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells .
26143638	0	Vascular_endothelial_growth_factor	0,34	CA125	68,73	Vascular endothelial growth factor	CA125	7422	94025	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Vascular_endothelial_growth_factor expression correlates with serum CA125 and represents a useful tool in prediction of refractoriness to platinum-based chemotherapy and ascites formation in epithelial_ovarian_cancer .
10233851	0	Vascular_endothelial_growth_factor	0,34	CXCR4	91,96	Vascular endothelial growth factor	CXCR4	7422	7852	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor and basic_fibroblast_growth_factor induce expression of CXCR4 on human endothelial cells : In vivo neovascularization induced by stromal-derived factor-1alpha .
12499259	0	Vascular_endothelial_growth_factor	0,34	CXCR4	130,135	Vascular endothelial growth factor	CXCR4	7422	7852	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Vascular_endothelial_growth_factor promotes breast_carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4 .
9393770	0	Vascular_endothelial_growth_factor	0,34	FLT-1	89,94	Vascular endothelial growth factor	FLT-1	7422	2321	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|receptor receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor up-regulates its receptor fms-like_tyrosine_kinase_1 -LRB- FLT-1 -RRB- and a soluble variant of FLT-1 in human vascular endothelial cells .
14988387	0	Vascular_endothelial_growth_factor	0,34	Flk-1	53,58	Vascular endothelial growth factor	Flk-1	281572(Tax:9913)	407170(Tax:9913)	Gene	Gene	START_ENTITY|appos|KDR KDR|compound|END_ENTITY	Vascular_endothelial_growth_factor and its receptor , Flk-1 / KDR , are cytoprotective in the extravascular compartment of the ovarian follicle .
10787417	0	Vascular_endothelial_growth_factor	0,34	ICAM-1	48,54	Vascular endothelial growth factor	ICAM-1	83785(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Vascular_endothelial_growth_factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric _ oxide pathway and modulates migration of brain microvascular endothelial cells .
10793084	0	Vascular_endothelial_growth_factor	0,34	ICAM-1	130,136	Vascular endothelial growth factor	ICAM-1	83785(Tax:10116)	25464(Tax:10116)	Gene	Gene	START_ENTITY|dep|permeability permeability|acl:relcl|mediated mediated|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced retinal_vascular permeability is mediated by intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- .
11108718	0	Vascular_endothelial_growth_factor	0,34	ICAM-1	84,90	Vascular endothelial growth factor	ICAM-1	7422	3383	Gene	Gene	expression|amod|START_ENTITY expression|nmod|intercellular_adhesion_molecule_1 intercellular_adhesion_molecule_1|appos|END_ENTITY	Vascular_endothelial_growth_factor expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- , and E-selectin through nuclear factor-kappa B activation in endothelial cells .
10037737	0	Vascular_endothelial_growth_factor	0,34	KDR	44,47	Vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues .
10455194	0	Vascular_endothelial_growth_factor	0,34	KDR	118,121	Vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|activation activation|compound|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
10850461	0	Vascular_endothelial_growth_factor	0,34	KDR	35,38	Vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	START_ENTITY|parataxis|activated activated|nsubj|END_ENTITY	Vascular_endothelial_growth_factor / KDR activated microvessel density versus CD31 standard microvessel density in non-small_cell_lung_cancer .
11018037	0	Vascular_endothelial_growth_factor	0,34	KDR	93,96	Vascular endothelial growth factor	KDR	281572(Tax:9913)	407170(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|connective_tissue_growth_factor connective_tissue_growth_factor|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces expression of connective_tissue_growth_factor via KDR , Flt1 , and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal_vascular_cells .
11058594	0	Vascular_endothelial_growth_factor	0,34	KDR	35,38	Vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Vascular_endothelial_growth_factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells .
15262130	0	Vascular_endothelial_growth_factor	0,34	KDR	170,173	Vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|transducers transducers|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- and ovarian_carcinoma cell supernatant activate signal transducers and activators of transcription -LRB- STATs -RRB- via VEGF receptor-2 -LRB- KDR -RRB- in human hemopoietic progenitor cells .
18164591	0	Vascular_endothelial_growth_factor	0,34	KDR	113,116	Vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|regulation regulation|nmod|END_ENTITY	Vascular_endothelial_growth_factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast_growth_factor-2 .
20367253	0	Vascular_endothelial_growth_factor	0,34	KDR	66,69	Vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	fetal_liver_kinase_1|compound|START_ENTITY fetal_liver_kinase_1|dep|insult insult|dep|receptor receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor / kinase insult domain receptor -LRB- KDR -RRB- / fetal_liver_kinase_1 -LRB- FLK1 -RRB- - mediated skin-epithelial progenitor cells reprogramming .
16410078	0	Vascular_endothelial_growth_factor	0,34	NFkappaB	87,95	Vascular endothelial growth factor	NFkappaB	7422	4790	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Vascular_endothelial_growth_factor signalling in endothelial cell survival : a role for NFkappaB .
16685275	0	Vascular_endothelial_growth_factor	0,34	Src	118,121	Vascular endothelial growth factor	Src	7422	6714	Gene	Gene	receptor-1|compound|START_ENTITY mediates|nsubj|receptor-1 mediates|nmod|activation activation|nmod|kinases kinases|compound|END_ENTITY	Vascular_endothelial_growth_factor receptor-1 mediates migration of human colorectal_carcinoma cells by activation of Src family kinases .
11866538	0	Vascular_endothelial_growth_factor	0,34	Tie-2	49,54	Vascular endothelial growth factor	Tie-2	7422	7010	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Vascular_endothelial_growth_factor modulates the Tie-2 : Tie-1 receptor complex .
12875855	0	Vascular_endothelial_growth_factor	0,34	Tie-2	47,52	Vascular endothelial growth factor	Tie-2	7422	7010	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Vascular_endothelial_growth_factor and soluble Tie-2 receptor in colorectal_cancer : associations with disease recurrence .
9625748	0	Vascular_endothelial_growth_factor	0,34	VE-cadherin	43,54	Vascular endothelial growth factor	VE-cadherin	7422	1003	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Vascular_endothelial_growth_factor induces VE-cadherin tyrosine phosphorylation in endothelial cells .
10944602	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression is a prognostic factor for radiotherapy outcome in advanced carcinoma_of_the_cervix .
11398859	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the subacromial bursa is increased in patients with impingement_syndrome .
11491018	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression regulates angiogenesis accompanying tumor growth in a peritoneal disseminated tumor model .
11506249	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in peritoneal_dialysis effluent .
11545235	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in oral tissues : possible relevance to angiogenesis , tumour_progression_and_field_cancerisation .
12706123	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 signaling mediates VEGF-C -LRB- deltaNdeltaC -RRB- - and VEGF-A-induced angiogenesis in vitro .
12969663	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and the effect of exogenous VEGF on survival of a random flap in the rat .
12969663	0	Vascular_endothelial_growth_factor	0,34	VEGF	81,85	Vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and the effect of exogenous VEGF on survival of a random flap in the rat .
15233640	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor neuropilin-1 's distribution in astrocytic_tumors .
15601306	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels as a tool to discriminate between malignant and nonmalignant ascites .
17279364	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels of gingiva and gingival crevicular fluid in diabetic and systemically healthy periodontitis patients .
17348829	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- inhibition -- a critical review .
17486644	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor antibody bevacizumab -LRB- avastin -RRB- induces regression of renal_cell_carcinoma in an adolescent resulting in residual tumorectomy .
17897503	0	Vascular_endothelial_growth_factor	0,34	VEGF	47,51	Vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor expression -LRB- VEGF -RRB- in salivary glands of diabetic rats .
18721343	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- response to dental trauma : a preliminary study in rats .
19968501	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- serum levels are associated with survival in early stages of lung_cancer patients .
20417690	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- polymorphism is associated with treatment_resistant_depression .
21344505	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms and gastric_cancer risk in a Chinese Han population .
22139971	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	influence|nsubj|START_ENTITY influence|dep|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms may influence the efficacy of thalidomide in multiple_myeloma .
22209952	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- +405 _ C/G polymorphism is associated with essential hypertension in a population from Tehran of Iran .
23098265	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors : drugs and new inhibitors .
23618468	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in locally advanced prostate_cancer : secondary analysis of radiation therapy oncology group -LRB- RTOG -RRB- 8610 .
23725153	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms and breast_cancer risk in a Chinese population .
25106408	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms and breast_cancer risk in Punjabi population from North West India .
25230786	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- pathway and neuroendocrine_neoplasms -LRB- NENs -RRB- : prognostic and therapeutic considerations .
25344824	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in short , GH treated children : a distinct pattern of VEGF-C in Noonan_syndrome .
26113661	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- regulation by hypoxia inducible factor-1 alpha -LRB- HIF1A -RRB- starts and peaks during endometrial breakdown , not repair , in a mouse menstrual-like model .
26486233	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- -634 G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level .
8589021	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA expression in human tumor models of different histologies .
8671190	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- concentrations are elevated in peritoneal fluid of women with endometriosis .
9815864	0	Vascular_endothelial_growth_factor	0,34	VEGF	36,40	Vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human coronary_atherosclerotic_lesions : possible pathophysiological significance of VEGF in progression of atherosclerosis .
12670505	0	Vascular_endothelial_growth_factor	0,34	VEGFR-1	96,103	Vascular endothelial growth factor	VEGFR-1	7422	2321	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor upregulates pigment_epithelium-derived_factor expression via VEGFR-1 in human retinal pigment epithelial cells .
20606037	0	Vascular_endothelial_growth_factor	0,34	VEGFR-2	45,52	Vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Vascular_endothelial_growth_factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers .
26107411	0	Vascular_endothelial_growth_factor	0,34	VEGFR-2	90,97	Vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Vascular_endothelial_growth_factor from Trimeresurus jerdonii venom specifically binds to VEGFR-2 .
7681826	0	Vascular_endothelial_growth_factor	0,34	alpha_2-macroglobulin	64,85	Vascular endothelial growth factor	alpha 2-macroglobulin	7422	2	Gene	Gene	inactivated|nsubjpass|START_ENTITY inactivated|advcl|binding binding|advcl|END_ENTITY	Vascular_endothelial_growth_factor is inactivated by binding to alpha_2-macroglobulin and the binding is inhibited by heparin .
19536308	0	Vascular_endothelial_growth_factor	0,34	annexin_A2	61,71	Vascular endothelial growth factor	annexin A2	22339(Tax:10090)	12306(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor upregulates expression of annexin_A2 in vitro and in a mouse model of ischemic_retinopathy .
22877565	0	Vascular_endothelial_growth_factor	0,34	apolipoprotein_M	49,65	Vascular endothelial growth factor	apolipoprotein M	22339(Tax:10090)	55938(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|compound|END_ENTITY	Vascular_endothelial_growth_factor downregulates apolipoprotein_M expression by inhibiting Foxa2 in a Nur77-dependent manner .
9808152	0	Vascular_endothelial_growth_factor	0,34	basic_fibroblast_growth_factor	60,90	Vascular endothelial growth factor	basic fibroblast growth factor	281572(Tax:9913)	281161(Tax:9913)	Gene	Gene	START_ENTITY|dep|synergizes synergizes|nmod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - C synergizes with basic_fibroblast_growth_factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity .
19754224	0	Vascular_endothelial_growth_factor	0,34	bone_morphogenetic_protein_2	44,72	Vascular endothelial growth factor	bone morphogenetic protein 2	83785(Tax:10116)	29373(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor inhibits bone_morphogenetic_protein_2 expression in rat mesenchymal stem cells .
20085644	0	Vascular_endothelial_growth_factor	0,34	c-MET	125,130	Vascular endothelial growth factor	c-MET	7422	4233	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Vascular_endothelial_growth_factor regulates myeloid_cell_leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate_cancer cells .
10455194	0	Vascular_endothelial_growth_factor	0,34	c-Src	136,141	Vascular endothelial growth factor	c-Src	7422	6714	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|activation activation|nmod|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
16244586	0	Vascular_endothelial_growth_factor	0,34	c-erbB-2	36,44	Vascular endothelial growth factor	c-erbB-2	7422	2064	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor , c-erbB-2 and c-erbB-3 expression in colorectal_adenoma and adenocarcinoma .
21276205	0	Vascular_endothelial_growth_factor	0,34	catalase	145,153	Vascular endothelial growth factor	catalase	83785(Tax:10116)	24248(Tax:10116)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Vascular_endothelial_growth_factor protects post-ganglionic sympathetic neurones from the detrimental effects of hydrogen_peroxide by increasing catalase .
11018037	0	Vascular_endothelial_growth_factor	0,34	connective_tissue_growth_factor	57,88	Vascular endothelial growth factor	connective tissue growth factor	281572(Tax:9913)	281103(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces expression of connective_tissue_growth_factor via KDR , Flt1 , and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal_vascular_cells .
12107271	0	Vascular_endothelial_growth_factor	0,34	cyclooxygenase-2	48,64	Vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor up-regulates cyclooxygenase-2 expression in human endothelial cells .
21867538	0	Vascular_endothelial_growth_factor	0,34	cyclooxygenase-2	125,141	Vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|adhesion adhesion|nmod|microenvironment microenvironment|nmod|END_ENTITY	Vascular_endothelial_growth_factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2 .
9450544	0	Vascular_endothelial_growth_factor	0,34	cytosolic_phospholipase_A2	88,114	Vascular endothelial growth factor	cytosolic phospholipase A2	7422	5321	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Vascular_endothelial_growth_factor stimulates prostacyclin production and activation of cytosolic_phospholipase_A2 in endothelial cells via p42/p44 mitogen-activated protein kinase .
23726969	0	Vascular_endothelial_growth_factor	0,34	endostatin	54,64	Vascular endothelial growth factor	endostatin	22339(Tax:10090)	12822(Tax:10090)	Gene	Gene	START_ENTITY|nmod|biomarker biomarker|nmod|therapy therapy|amod|END_ENTITY	Vascular_endothelial_growth_factor as a biomarker for endostatin gene therapy .
17469009	0	Vascular_endothelial_growth_factor	0,34	endothelin-1	43,55	Vascular endothelial growth factor	endothelin-1	7422	1906	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Vascular_endothelial_growth_factor induces endothelin-1 production via matrix_metalloproteinase-2 rather than endothelin-converting_enzyme-1 .
15705187	0	Vascular_endothelial_growth_factor	0,34	erythropoietin	90,104	Vascular endothelial growth factor	erythropoietin	7422	2056	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	Vascular_endothelial_growth_factor and its soluble receptor , Flt-1 , are not correlated to erythropoietin in diabetics with normal or reduced renal function .
16796823	0	Vascular_endothelial_growth_factor	0,34	erythropoietin	49,63	Vascular endothelial growth factor	erythropoietin	7422	2056	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Vascular_endothelial_growth_factor induces brain erythropoietin expression ?
11090059	0	Vascular_endothelial_growth_factor	0,34	fibrinogen	44,54	Vascular endothelial growth factor	fibrinogen	7422	2244	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Vascular_endothelial_growth_factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation .
18164591	0	Vascular_endothelial_growth_factor	0,34	fibroblast_growth_factor-2	136,162	Vascular endothelial growth factor	fibroblast growth factor-2	7422	2247	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	Vascular_endothelial_growth_factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast_growth_factor-2 .
10455194	0	Vascular_endothelial_growth_factor	0,34	flk-1	112,117	Vascular endothelial growth factor	flk-1	7422	3791	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|activation activation|amod|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
11122336	0	Vascular_endothelial_growth_factor	0,34	flk-1	106,111	Vascular endothelial growth factor	flk-1	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	factor|nsubj|START_ENTITY factor|acl:relcl|stimulates stimulates|nmod|receptor receptor|amod|END_ENTITY	Vascular_endothelial_growth_factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor .
9776730	0	Vascular_endothelial_growth_factor	0,34	flt-1	132,137	Vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|dep|role role|nmod|END_ENTITY	Vascular_endothelial_growth_factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells : role of flt-1 .
12844492	0	Vascular_endothelial_growth_factor	0,34	focal_adhesion_kinase	142,163	Vascular endothelial growth factor	focal adhesion kinase	7422	5747	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Vascular_endothelial_growth_factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal_adhesion_kinase and related_adhesion_focal_tyrosine_kinase .
9468491	0	Vascular_endothelial_growth_factor	0,34	heparin-binding_epidermal_growth_factor-like_growth_factor	43,101	Vascular endothelial growth factor	heparin-binding epidermal growth factor-like growth factor	7422	1839	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Vascular_endothelial_growth_factor induces heparin-binding_epidermal_growth_factor-like_growth_factor in vascular endothelial cells .
12727858	0	Vascular_endothelial_growth_factor	0,34	hypoxia-inducible_factor_1	116,142	Vascular endothelial growth factor	hypoxia-inducible factor 1	7422	3091	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|advcl|END_ENTITY	Vascular_endothelial_growth_factor gene expression in colon_cancer cells exposed to prostaglandin_E2 is mediated by hypoxia-inducible_factor_1 .
15337760	0	Vascular_endothelial_growth_factor	0,34	hypoxia-inducible_factor_1alpha	77,108	Vascular endothelial growth factor	hypoxia-inducible factor 1alpha	7422	3091	Gene	Gene	activation|amod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|END_ENTITY	Vascular_endothelial_growth_factor transcriptional activation is mediated by hypoxia-inducible_factor_1alpha , HDM2 , and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling .
19048467	0	Vascular_endothelial_growth_factor	0,34	inducible_nitric_oxide_synthase	47,78	Vascular endothelial growth factor	inducible nitric oxide synthase	83785(Tax:10116)	24599(Tax:10116)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor upregulates inducible_nitric_oxide_synthase expression in the muscle flap ischemia model in the rat .
11108718	0	Vascular_endothelial_growth_factor	0,34	intercellular_adhesion_molecule_1	49,82	Vascular endothelial growth factor	intercellular adhesion molecule 1	7422	3383	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- , and E-selectin through nuclear factor-kappa B activation in endothelial cells .
17525365	0	Vascular_endothelial_growth_factor	0,34	interleukin-6	76,89	Vascular endothelial growth factor	interleukin-6	7422	3569	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Vascular_endothelial_growth_factor is induced by the inflammatory cytokines interleukin-6 and oncostatin_m in human adipose tissue in vitro and in murine adipose tissue in vivo .
11784713	0	Vascular_endothelial_growth_factor	0,34	interleukin-8	104,117	Vascular endothelial growth factor	interleukin-8	7422	3576	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|migration migration|nmod|up-regulation up-regulation|nmod|cells cells|amod|END_ENTITY	Vascular_endothelial_growth_factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells .
19236815	0	Vascular_endothelial_growth_factor	0,34	intracellular_adhesion_molecule-1	66,99	Vascular endothelial growth factor	intracellular adhesion molecule-1	281572(Tax:9913)	281839(Tax:9913)	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor up-regulates the expression of intracellular_adhesion_molecule-1 in retinal endothelial cells via reactive oxygen species , but not nitric_oxide .
11641265	0	Vascular_endothelial_growth_factor	0,34	manganese-superoxide_dismutase	43,73	Vascular endothelial growth factor	manganese-superoxide dismutase	7422	6648	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor induces manganese-superoxide_dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism .
17469009	0	Vascular_endothelial_growth_factor	0,34	matrix_metalloproteinase-2	71,97	Vascular endothelial growth factor	matrix metalloproteinase-2	7422	4313	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces endothelin-1 production via matrix_metalloproteinase-2 rather than endothelin-converting_enzyme-1 .
14971873	0	Vascular_endothelial_growth_factor	0,34	matrix_metalloproteinase-9	51,77	Vascular endothelial growth factor	matrix metalloproteinase-9	7422	4318	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Vascular_endothelial_growth_factor correlates with matrix_metalloproteinase-9 in the pleural_effusion .
16645174	0	Vascular_endothelial_growth_factor	0,34	matrix_metalloproteinase-9	45,71	Vascular endothelial growth factor	matrix metalloproteinase-9	7422	4318	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor modulates matrix_metalloproteinase-9 expression in asthma .
20085644	0	Vascular_endothelial_growth_factor	0,34	myeloid_cell_leukemia-1	45,68	Vascular endothelial growth factor	myeloid cell leukemia-1	7422	4170	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor regulates myeloid_cell_leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate_cancer cells .
15233640	0	Vascular_endothelial_growth_factor	0,34	neuropilin-1	51,63	Vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor neuropilin-1 's distribution in astrocytic_tumors .
18723443	0	Vascular_endothelial_growth_factor	0,34	neuropilin-1	57,69	Vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|endocytosis endocytosis|amod|END_ENTITY	Vascular_endothelial_growth_factor and semaphorin induce neuropilin-1 endocytosis via separate pathways .
25777560	0	Vascular_endothelial_growth_factor	0,34	neuropilin-1	85,97	Vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	factor|nsubj|START_ENTITY factor|advcl|signalling signalling|nmod|END_ENTITY	Vascular_endothelial_growth_factor is an autocrine growth factor , signalling through neuropilin-1 in non-small cell lung_cancer .
25889301	0	Vascular_endothelial_growth_factor	0,34	neuropilin-1	84,96	Vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	factor|nsubj|START_ENTITY factor|advcl|signaling signaling|nmod|END_ENTITY	Vascular_endothelial_growth_factor is an autocrine growth factor , signaling through neuropilin-1 in non-small cell lung_cancer .
25889301	0	Vascular_endothelial_growth_factor	0,34	neuropilin-1	84,96	Vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	factor|nsubj|START_ENTITY factor|advcl|signaling signaling|nmod|END_ENTITY	Vascular_endothelial_growth_factor is an autocrine growth factor , signaling through neuropilin-1 in non-small cell lung_cancer .
10438525	0	Vascular_endothelial_growth_factor	0,34	occludin	92,100	Vascular endothelial growth factor	occludin	83785(Tax:10116)	83497(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1 .
26221892	0	Vascular_endothelial_growth_factor	0,34	occludin	97,105	Vascular endothelial growth factor	occludin	7422	100506658	Gene	Gene	increases|nsubj|START_ENTITY increases|advcl|affecting affecting|dobj|distributions distributions|nmod|assembly assembly|amod|END_ENTITY	Vascular_endothelial_growth_factor increases GEnC permeability by affecting the distributions of occludin , ZO-1 and tight juction assembly .
26221892	0	Vascular_endothelial_growth_factor	0,34	occludin	97,105	Vascular endothelial growth factor	occludin	7422	100506658	Gene	Gene	increases|nsubj|START_ENTITY increases|advcl|affecting affecting|dobj|distributions distributions|nmod|assembly assembly|amod|END_ENTITY	Vascular_endothelial_growth_factor increases GEnC permeability by affecting the distributions of occludin , ZO-1 and tight juction assembly .
10779196	0	Vascular_endothelial_growth_factor	0,34	p53	62,65	Vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|mutation mutation|compound|END_ENTITY	Vascular_endothelial_growth_factor expression correlates with p53 mutation and angiogenesis in squamous_cell_carcinoma of the head_and_neck .
12168898	0	Vascular_endothelial_growth_factor	0,34	p53	69,72	Vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|nsubj|START_ENTITY expression|nmod|expressions expressions|compound|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression correlates with p53 and ki-67 expressions in tongue_squamous_cell_carcinoma .
8804365	0	Vascular_endothelial_growth_factor	0,34	phospholipase_D	73,88	Vascular endothelial growth factor	phospholipase D	7422	2822	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Vascular_endothelial_growth_factor stimulates protein kinase C-dependent phospholipase_D activity in endothelial cells .
12670505	0	Vascular_endothelial_growth_factor	0,34	pigment_epithelium-derived_factor	47,80	Vascular endothelial growth factor	pigment epithelium-derived factor	7422	57104	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor upregulates pigment_epithelium-derived_factor expression via VEGFR-1 in human retinal pigment epithelial cells .
18164591	0	Vascular_endothelial_growth_factor	0,34	stanniocalcin-1	45,60	Vascular endothelial growth factor	stanniocalcin-1	7422	6781	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast_growth_factor-2 .
21474827	0	Vascular_endothelial_growth_factor	0,34	stanniocalcin-1	63,78	Vascular endothelial growth factor	stanniocalcin-1	7422	6781	Gene	Gene	START_ENTITY|dep|D D|acl:relcl|stimulates stimulates|dobj|VEGF-A VEGF-A|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - D stimulates VEGF-A , stanniocalcin-1 , and neuropilin-2 and has potent angiogenic effects .
10810442	0	Vascular_endothelial_growth_factor	0,34	thymidine_phosphorylase	98,121	Vascular endothelial growth factor	thymidine phosphorylase	7422	1890	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression in progression of cervical_cancer : correlation with thymidine_phosphorylase expression , angiogenesis , tumor cell proliferation , and apoptosis .
17170373	0	Vascular_endothelial_growth_factor	0,34	tumor_necrosis_factor-alpha	87,114	Vascular endothelial growth factor	tumor necrosis factor-alpha	100008899(Tax:9986)	100009088(Tax:9986)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Vascular_endothelial_growth_factor synergistically enhances induction of E-selectin by tumor_necrosis_factor-alpha .
9201618	0	Vascular_endothelial_growth_factor	0,34	tumor_necrosis_factor-alpha	82,109	Vascular endothelial growth factor	tumor necrosis factor-alpha	7422	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	Vascular_endothelial_growth_factor inhibits endothelial cell apoptosis induced by tumor_necrosis_factor-alpha : balance between growth and death signals .
11950700	0	Vascular_endothelial_growth_factor	0,34	vascular_endothelial_cadherin	64,93	Vascular endothelial growth factor	vascular endothelial cadherin	7422	1003	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces SHC association with vascular_endothelial_cadherin : a potential feedback mechanism to control vascular_endothelial_growth_factor receptor-2 signaling .
9323935	0	Vascular_endothelial_growth_factor	0,34	vascular_endothelial_growth_factor	148,182	Vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Vascular_endothelial_growth_factor and severity of nonproliferative_diabetic_retinopathy mediate retinal hemodynamics in vivo : a potential role for vascular_endothelial_growth_factor in the progression of nonproliferative_diabetic_retinopathy .
23394931	0	Vascular_endothelial_growth_factor-A	0,36	EphB4	46,51	Vascular endothelial growth factor-A	EphB4	7422	2050	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Vascular_endothelial_growth_factor-A inhibits EphB4 and stimulates delta-like_ligand_4 expression in adult endothelial cells .
18554584	0	Vascular_endothelial_growth_factor-A	0,36	Snail	48,53	Vascular endothelial growth factor-A	Snail	7422	6615	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Vascular_endothelial_growth_factor-A stimulates Snail expression in breast_tumor cells : implications for tumor progression .
22231433	0	Vascular_endothelial_growth_factor_A	0,36	VEGFA	43,48	Vascular endothelial growth factor A	VEGFA	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Vascular_endothelial_growth_factor_A gene -LRB- VEGFA -RRB- polymorphisms and expression of VEGFA gene in lung_cancer patients of Kashmir Valley -LRB- India -RRB- .
9751730	0	Vascular_endothelial_growth_factor_B	0,36	VEGF	55,59	Vascular endothelial growth factor B	VEGF	7423	7422	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Vascular_endothelial_growth_factor_B -LRB- VEGF-B -RRB- binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells .
25270205	0	Vascular_endothelial_growth_factor_C	1,37	LYVE-1	46,52	Vascular endothelial growth factor C	LYVE-1	7424	10894	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|amod|END_ENTITY	-LSB- Vascular_endothelial_growth_factor_C induces LYVE-1 -LRB- + -RRB- endothelial cells to reconstruct hepatic sinusoid during liver regeneration -RSB- .
26216169	0	Vascular_endothelial_growth_factor_C	0,36	VEGF-C	38,44	Vascular endothelial growth factor C	VEGF-C	7424	7424	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor_C -LRB- VEGF-C -RRB- expression predicts metastasis in tongue_cancer .
26194852	0	Vascular_endothelial_growth_factor_receptor-2	0,45	VEGFR-2	47,54	Vascular endothelial growth factor receptor-2	VEGFR-2	3791	3791	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- inhibitors : development and validation of predictive 3-D QSAR models through extensive ligand - and structure-based approaches .
23164459	0	Vascular_endothelial_growth_factor_receptor_2	0,45	KDR	52,55	Vascular endothelial growth factor receptor 2	KDR	3791	3791	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Vascular_endothelial_growth_factor_receptor_2 gene -LRB- KDR -RRB- polymorphisms and expression levels in depressive_disorder .
12461084	0	Vascular_permeability_factor	0,28	vascular_endothelial_growth_factor	29,63	Vascular permeability factor	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Vascular_permeability_factor / vascular_endothelial_growth_factor induces lymphangiogenesis as well as angiogenesis .
9426404	0	Vascular_permeability_factor	0,28	vascular_endothelial_growth_factor	29,63	Vascular permeability factor	vascular endothelial growth factor	7422	7422	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Vascular_permeability_factor / vascular_endothelial_growth_factor and its receptors in oral and laryngeal_squamous_cell_carcinoma and dysplasia .
22426063	0	Vasn	23,27	vasorin	14,21	Vasn	vasorin	246154(Tax:10090)	246154(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of vasorin -LRB- Vasn -RRB- during embryonic development of the mouse .
11812772	0	Vasoactive_intestinal_peptide_receptor-1	0,40	Ikaros	119,125	Vasoactive intestinal peptide receptor-1	Ikaros	7433	10320	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- is a novel gene target of the hemolymphopoietic transcription factor Ikaros .
1713357	0	Vasoactive_intestinal_polypeptide	0,33	c-myc	43,48	Vasoactive intestinal polypeptide	c-myc	7432	4609	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Vasoactive_intestinal_polypeptide inhibits c-myc expression and growth of human gastric_carcinoma cells .
11876785	0	Vasoactive_intestinal_polypeptide	0,33	per1	42,46	Vasoactive intestinal polypeptide	per1	117064(Tax:10116)	287422(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Vasoactive_intestinal_polypeptide induces per1 and per2 gene expression in the rat suprachiasmatic nucleus late at night .
8032686	0	Vasoactive_intestinal_polypeptide	0,33	prolactin	56,65	Vasoactive intestinal polypeptide	prolactin	117064(Tax:10116)	24683(Tax:10116)	Gene	Gene	antiserum|compound|START_ENTITY affects|nsubj|antiserum affects|dobj|mRNA mRNA|compound|END_ENTITY	Vasoactive_intestinal_polypeptide antiserum affects rat prolactin mRNA in 40-day but not 110-day diethylstilbestrol-induced prolactinoma tissue .
12492113	0	Vasodilator-stimulated_phosphoprotein	0,37	VASP	39,43	Vasodilator-stimulated phosphoprotein	VASP	7408	7408	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- phosphorylation provides a biomarker for the action of exisulind and related agents that activate protein_kinase_G .
21043609	0	Vasopressin	56,67	Vasopressinase	6,20	Vasopressin	Vasopressinase	551	4012	Gene	Gene	Serum|nmod|START_ENTITY Serum|dobj|Responses Responses|compound|END_ENTITY	Serum Vasopressinase and Platelet Responses to Arginine Vasopressin in Normal Pregnancy , Pregnancy-induced Hypertension and Pre-eclampsia .
10096773	0	Vasopressin	0,11	vascular_endothelial_growth_factor	22,56	Vasopressin	vascular endothelial growth factor	551	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|secretion secretion|compound|END_ENTITY	Vasopressin increases vascular_endothelial_growth_factor secretion from human vascular smooth muscle cells .
21299514	0	Vasopressin	0,11	vasopressin	36,47	Vasopressin	vasopressin	551	551	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Vasopressin versus a combination of vasopressin and tourniquets : a comparison of blood_loss in patients undergoing abdominal myomectomies .
11794467	0	Vasopressin-activated_calcium-mobilizing	0,40	VACM-1	42,48	Vasopressin-activated calcium-mobilizing	VACM-1	64624(Tax:10116)	64624(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Vasopressin-activated_calcium-mobilizing -LRB- VACM-1 -RRB- receptor mRNA is present in peripheral organs and the central nervous system of the laboratory_rat .
21043609	0	Vasopressinase	6,20	Vasopressin	56,67	Vasopressinase	Vasopressin	4012	551	Gene	Gene	Responses|compound|START_ENTITY Serum|dobj|Responses Serum|nmod|END_ENTITY	Serum Vasopressinase and Platelet Responses to Arginine Vasopressin in Normal Pregnancy , Pregnancy-induced Hypertension and Pre-eclampsia .
23135225	0	Vaspin	0,6	ERK	61,64	Vaspin	ERK	145264	5594	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway .
16177062	0	Vav	70,73	CD244	37,42	Vav	CD244	7409	51744	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	The adaptor protein 3BP2 binds human CD244 and links this receptor to Vav signaling , ERK activation , and NK cell killing .
10725744	0	Vav	0,3	CD28	90,94	Vav	CD28	7409	940	Gene	Gene	synergizes|compound|START_ENTITY kinase|nsubj|synergizes kinase|xcomp|mediate mediate|nmod|costimulation costimulation|nummod|END_ENTITY	Vav synergizes with protein kinase C theta to mediate IL-4 gene expression in response to CD28 costimulation in T cells .
11813163	0	Vav	0,3	CD28	20,24	Vav	CD28	7409	940	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated_kinase_kinase_1 .
9620604	0	Vav	105,108	CD28	28,32	Vav	CD28	7409	940	Gene	Gene	phosphorylation|nmod|START_ENTITY involved|nmod|phosphorylation involved|nsubjpass|regions regions|nmod|domain domain|compound|END_ENTITY	Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein .
17339478	0	Vav	118,121	CEACAM3	84,91	Vav	CEACAM3	7409	1084	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	The granulocyte receptor carcinoembryonic antigen-related cell adhesion molecule 3 -LRB- CEACAM3 -RRB- directly associates with Vav to promote phagocytosis of human pathogens .
10748082	0	Vav	99,102	Dbl	75,78	Vav	Dbl	7409	4168	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding .
11007481	0	Vav	91,94	Dbl	53,56	Vav	Dbl	7409	4168	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation .
8649418	0	Vav	15,18	ENX-1	24,29	Vav	ENX-1	7409	2146	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Vav with ENX-1 , a putative transcriptional regulator of homeobox gene expression .
7809090	0	Vav	11,14	Grb2	18,22	Vav	Grb2	7409	2885	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of Vav to Grb2 through dimerization of Src homology 3 domains .
7651724	0	Vav	55,58	Interleukin_3	0,13	Vav	Interleukin 3	7409	3562	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	Interleukin_3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain .
15661896	0	Vav	66,69	Itk	33,36	Vav	Itk	7409	3702	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton .
11950933	0	Vav	0,3	Rac	28,31	Vav	Rac	7409	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|nmod|END_ENTITY	Vav regulates activation of Rac but not Cdc42 during FcgammaR-mediated phagocytosis .
16882714	0	Vav	4,7	Syk	57,60	Vav	Syk	7409	6850	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin -LRB- CD11/CD18 -RRB- - mediated neutrophil migration .
10706671	0	Vav	91,94	WIP	14,17	Vav	WIP	7409	7456	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Cutting edge : WIP , a binding partner for Wiskott-Aldrich_syndrome protein , cooperates with Vav in the regulation of T cell activation .
9151714	0	Vav	4,7	ZAP-70	31,37	Vav	ZAP-70	7409	7535	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The Vav binding site -LRB- Y315 -RRB- in ZAP-70 is critical for antigen receptor-mediated signal transduction .
9200440	0	Vav	18,21	c-Cbl	37,42	Vav	c-Cbl	22324(Tax:10090)	12402(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells .
16950670	0	Vav	25,28	c-Fms	10,15	Vav	c-Fms	22324(Tax:10090)	12978(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts .
9013873	0	Vav	0,3	gp130	52,57	Vav	gp130	7409	3572	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Vav is associated with signal transducing molecules gp130 , Grb2 and Erk2 , and is tyrosine phosphorylated in response to interleukin-6 .
7559621	0	Vav	148,151	interleukin_2	83,96	Vav	interleukin 2	7409	3558	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Distinct isoforms of the CD45 protein-tyrosine phosphatase differentially regulate interleukin_2 secretion and activation signal pathways involving Vav in T cells .
16474842	0	Vav1	10,14	Bcl-2	65,70	Vav1	Bcl-2	7409	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|nmod|inhibition inhibition|nmod|proteins proteins|compound|END_ENTITY	Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoietic progenitor cell proliferation .
21151158	0	Vav1	56,60	Bcl-2	64,69	Vav1	Bcl-2	7409	596	Gene	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	The distinct role of guanine_nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells .
24880064	0	Vav1	0,4	Bcl-2	15,20	Vav1	Bcl-2	7409	596	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells .
22456277	0	Vav1	0,4	GEF	5,8	Vav1	GEF	22324(Tax:10090)	16800(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Vav1 GEF activity is required for T cell mediated allograft rejection .
19597340	0	Vav1	49,53	IDO	0,3	Vav1	IDO	7409	3620	Gene	Gene	expression|amod|START_ENTITY suppressing|dobj|expression inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	IDO inhibits T-cell function through suppressing Vav1 expression and activation .
24532586	0	Vav1	26,30	IL-6	100,104	Vav1	IL-6	22324(Tax:10090)	16193(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6 .
23391492	0	Vav1	0,4	MHCII	15,20	Vav1	MHCII	22324(Tax:10090)	111364(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Vav1 regulates MHCII expression in murine resting and activated B cells .
18094167	0	Vav1	77,81	Nef	36,39	Vav1	Nef	7409	6285	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated_kinase_2 activity .
11274147	0	Vav1	39,43	Protein_kinase_C_theta	0,22	Vav1	Protein kinase C theta	7409	5588	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Protein_kinase_C_theta cooperates with Vav1 to induce JNK activity in T-cells .
19060239	0	Vav1	34,38	T-cell_receptor	0,15	Vav1	T-cell receptor	7409	6962	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	T-cell_receptor - and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue .
22253833	0	Vav1	6,10	c-Myb	77,82	Vav1	c-Myb	7409	4602	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation .
23615439	0	Vav2	39,43	Paxillin_kinase_linker	0,22	Vav2	Paxillin kinase linker	7410	5313	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Paxillin_kinase_linker -LRB- PKL -RRB- regulates Vav2 signaling during cell spreading and migration .
10982832	0	Vav2	0,4	Rac1	15,19	Vav2	Rac1	7410	5879	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Vav2 activates Rac1 , Cdc42 , and RhoA downstream from growth factor receptors but not beta1 integrins .
17686471	0	Vav2	105,109	Rac1	13,17	Vav2	Rac1	7410	5879	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|activation activation|amod|END_ENTITY	VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine_nucleotide exchange factor Vav2 .
17996485	0	Vav2	10,14	Rac1	51,55	Vav2	Rac1	7410	5879	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral_squamous_cell_carcinoma .
22554804	0	Vav2	39,43	parathyroid_hormone_receptor	71,99	Vav2	parathyroid hormone receptor	7410	5745	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The guanine_nucleotide exchange factor Vav2 is a negative regulator of parathyroid_hormone_receptor / Gq signaling .
23931752	0	Vav3	43,47	Rac1	51,55	Vav3	Rac1	57257(Tax:10090)	19353(Tax:10090)	Gene	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Chronic sympathoexcitation through loss of Vav3 , a Rac1 activator , results in divergent effects on metabolic_syndrome and obesity depending on diet .
9931330	0	Vbp1	55,59	von_Hippel-Lindau-binding_protein-1	18,53	Vbp1	von Hippel-Lindau-binding protein-1	22327(Tax:10090)	22327(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the von_Hippel-Lindau-binding_protein-1 -LRB- Vbp1 -RRB- in fetal and adult mouse tissues .
23644099	0	Vdr	69,72	Opn	106,109	Vdr	Opn	22337(Tax:10090)	20750(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn during soft tissue calcification .
10477288	0	VegT	30,34	Bix4	0,4	VegT	Bix4	397990(Tax:8355)	398077(Tax:8355)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Bix4 is activated directly by VegT and mediates endoderm formation in Xenopus development .
15680368	0	VegT	37,41	SOX7	0,4	VegT	SOX7	397990(Tax:8355)	378665(Tax:8355)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SOX7 is an immediate-early target of VegT and regulates Nodal-related gene expression in Xenopus .
11518513	0	VegT	0,4	Sox17	19,24	VegT	Sox17	397990(Tax:8355)	397966(Tax:8355)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	VegT activation of Sox17 at the midblastula transition alters the response to nodal signals in the vegetal endoderm domain .
14568102	0	VegT	0,4	Xnr5	42,46	VegT	Xnr5	397990(Tax:8355)	780748(Tax:8355)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	VegT activation of the early zygotic gene Xnr5 requires lifting of Tcf-mediated repression in the Xenopus blastula .
18835464	0	Vegf	85,89	Hif-1alpha	98,108	Vegf	Hif-1alpha	7422	3091	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nmod|expression expression|compound|END_ENTITY	CCN family 2/connective tissue growth factor -LRB- CCN2/CTGF -RRB- regulates the expression of Vegf through Hif-1alpha expression in a chondrocytic cell line , HCS-2 / 8 , under hypoxic condition .
23888777	0	Vegfa	50,55	PGP	43,46	Vegfa	PGP	83785(Tax:10116)	287115(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- The effect of semax and its C-end peptide PGP on Vegfa gene expression in the rat brain during incomplete global ischemia -RSB- .
10666423	0	Vegfb	60,65	vascular_endothelial_growth_factor-B	17,53	Vegfb	vascular endothelial growth factor-B	22340(Tax:10090)	22340(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mice lacking the vascular_endothelial_growth_factor-B gene -LRB- Vegfb -RRB- have smaller hearts , dysfunctional coronary vasculature , and impaired recovery from cardiac_ischemia .
26382615	0	Vegfr2	15,21	TBX1	0,4	Vegfr2	TBX1	3791	6899	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2 + Cells .
20439995	0	Vegfr3	15,21	Tbx1	0,4	Vegfr3	Tbx1	2324	6899	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Tbx1 regulates Vegfr3 and is required for lymphatic vessel development .
9148809	0	Vera	36,40	Vg1	24,27	Vera	Vg1	394293(Tax:8355)	677862(Tax:8355)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum .
10221651	1	Versican	80,88	L-selectin	148,158	Versican	L-selectin	1462	6402	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	I. Versican , a large chondroitin sulfate proteoglycan , is a ligand for L-selectin .
25606449	0	Versican	15,23	VCAN	25,29	Versican	VCAN	1462	1462	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of Versican -LRB- VCAN -RRB- gene polymorphisms rs251124 and rs2287926 -LRB- G428D -RRB- , with intracranial_aneurysm .
24191038	0	Very_large_G_protein-coupled_receptor_1	0,39	myelin-associated_glycoprotein	50,80	Very large G protein-coupled receptor 1	myelin-associated glycoprotein	110789(Tax:10090)	17136(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Very_large_G_protein-coupled_receptor_1 regulates myelin-associated_glycoprotein via Gas/Gaq-mediated protein kinases A/C .
24293365	0	Very_low_density_lipoprotein_receptor	0,37	VLDLR	39,44	Very low density lipoprotein receptor	VLDLR	22359(Tax:10090)	22359(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Very_low_density_lipoprotein_receptor -LRB- VLDLR -RRB- expression is a determinant factor in adipose tissue inflammation and adipocyte-macrophage interaction .
7848269	0	Vesicle-associated_membrane_protein-2	0,37	synaptophysin	77,90	Vesicle-associated membrane protein-2	synaptophysin	6844	6855	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	Vesicle-associated_membrane_protein-2 -LRB- synaptobrevin-2 -RRB- forms a complex with synaptophysin .
12023275	0	Vesicle-associated_membrane_protein-associated_protein-A	0,56	oxysterol-binding_protein	84,109	Vesicle-associated membrane protein-associated protein-A	oxysterol-binding protein	9218	5007	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Vesicle-associated_membrane_protein-associated_protein-A -LRB- VAP-A -RRB- interacts with the oxysterol-binding_protein to modify export from the endoplasmic reticulum .
26053743	0	Vesicular_Glutamate_Transporter_2	14,47	vGluT2	49,55	Vesicular Glutamate Transporter 2	vGluT2	84487(Tax:10116)	84487(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Vesicular_Glutamate_Transporter_2 -LRB- vGluT2 -RRB- on Large Dense-Core Vesicles within GnRH Neuroterminals of Aging Female Rats .
16269145	0	Vesicular_monoamine_transporter-2	0,33	L-amino_acid_decarboxylase	47,73	Vesicular monoamine transporter-2	L-amino acid decarboxylase	25549(Tax:10116)	24311(Tax:10116)	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Vesicular_monoamine_transporter-2 and aromatic L-amino_acid_decarboxylase gene therapy prevents development of motor complications in parkinsonian rats after chronic intermittent L-3 ,4 - dihydroxyphenylalanine administration .
17016857	0	Vesl-1	39,45	Polycystin-1	0,12	Vesl-1	Polycystin-1	26556(Tax:10090)	18763(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Polycystin-1 can interact with homer_1 / Vesl-1 in postnatal hippocampal neurons .
2734307	0	Vg-1	43,47	Vgr-1	0,5	Vg-1	Vgr-1	677862(Tax:8355)	654	Gene	Gene	related|nmod|START_ENTITY gene|acl|related END_ENTITY|appos|gene	Vgr-1 , a mammalian gene related to Xenopus Vg-1 , is a member of the transforming growth factor beta gene superfamily .
9148809	0	Vg1	24,27	Vera	36,40	Vg1	Vera	677862(Tax:8355)	394293(Tax:8355)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Localization of Xenopus Vg1 mRNA by Vera protein and the endoplasmic reticulum .
7547504	0	Vgr-1	0,5	BMP-6	6,11	Vgr-1	BMP-6	654	654	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|END_ENTITY	Vgr-1 / BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells .
2734307	0	Vgr-1	0,5	Vg-1	43,47	Vgr-1	Vg-1	654	677862(Tax:8355)	Gene	Gene	START_ENTITY|appos|gene gene|acl|related related|nmod|END_ENTITY	Vgr-1 , a mammalian gene related to Xenopus Vg-1 , is a member of the transforming growth factor beta gene superfamily .
25359211	0	Vhl	58,61	Bap1	0,4	Vhl	Bap1	22346(Tax:10090)	104416(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis .
16533810	0	Vhr1p	0,5	VHT1	95,99	Vhr1p	VHT1	854755(Tax:4932)	852956(Tax:4932)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Vhr1p , a new transcription factor from budding yeast , regulates biotin-dependent expression of VHT1 and BIO5 .
23988114	0	Vif	94,97	CBF-b	77,82	Vif	CBF-b	155459(Tax:11676)	865	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|xcomp|binding	Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-b binding to Vif .
23333304	0	Vif	20,23	CBFb	0,4	Vif	CBFb	155459(Tax:11676)	865	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	CBFb stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression .
24212937	0	Vimentin	15,23	CD44	166,170	Vimentin	CD44	7431	960	Gene	Gene	Domains|nmod|START_ENTITY Expressed|nsubjpass|Domains Expressed|nmod|Surface Surface|dep|END_ENTITY	Two Domains of Vimentin Are Expressed on the Surface of Lymph Node , Bone and Brain Metastatic Prostate Cancer Lines along with the Putative Stem Cell Marker Proteins CD44 and CD133 .
26546435	0	Vimentin	21,29	CPEB4	0,5	Vimentin	CPEB4	7431	80315	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CPEB4 interacts with Vimentin and involves in progressive features and poor prognosis of patients with astrocytic_tumors .
22371530	0	Vimentin	0,8	Cdc2	28,32	Vimentin	Cdc2	7431	983	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth via b1-integrin activation .
17046786	0	Vimentin	0,8	Erk	35,38	Vimentin	Erk	7431	5594	Gene	Gene	binding|compound|START_ENTITY binding|nmod|END_ENTITY	Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase .
21057535	0	Vimentin	0,8	H-Ras	55,60	Vimentin	H-Ras	7431	3265	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast_cancer .
7691937	0	Vimentin	0,8	IL-2	51,55	Vimentin	IL-2	22352(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Vimentin expression is differentially regulated by IL-2 and IL-4 in murine T cells .
21216232	0	Vimentin	0,8	IRAP	15,19	Vimentin	IRAP	7431	4012	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	Vimentin binds IRAP and is involved in GLUT4 vesicle trafficking .
26369929	0	Vimentin	0,8	Rac1	87,91	Vimentin	Rac1	22352(Tax:10090)	19353(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Vimentin is involved in regulation of mitochondrial motility and membrane potential by Rac1 .
2153347	0	Vimentin	0,8	estrogen_receptor	73,90	Vimentin	estrogen receptor	7431	2099	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	Vimentin is preferentially expressed in human breast_carcinomas with low estrogen_receptor and high Ki-67 growth fraction .
23353576	0	Vimentin	0,8	mu_opioid_receptor	60,78	Vimentin	mu opioid receptor	22352(Tax:10090)	18390(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Vimentin interacts with the 5 ' - untranslated region of mouse mu_opioid_receptor -LRB- MOR -RRB- and is required for post-transcriptional regulation .
20086044	0	Vinculin	0,8	E-cadherin	32,42	Vinculin	E-cadherin	7414	999	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin .
20584916	0	Vinculin	0,8	E-cadherin	21,31	Vinculin	E-cadherin	7414	999	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|mechanosensing mechanosensing|amod|END_ENTITY	Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner .
9405455	0	Vinculin	0,8	E-cadherin	32,42	Vinculin	E-cadherin	7414	999	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|complex complex|amod|END_ENTITY	Vinculin is associated with the E-cadherin adhesion complex .
15579911	0	Vinculin	0,8	PTEN	18,22	Vinculin	PTEN	7414	5728	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|level level|compound|END_ENTITY	Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2 .
26649283	0	Vinculin	0,8	TarP	47,51	Vinculin	TarP	7414	445347	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	Vinculin Interacts with the Chlamydia Effector TarP Via a Tripartite Vinculin Binding Domain to Mediate Actin Recruitment and Assembly at the Plasma Membrane .
22391038	0	Vinculin	0,8	VE-cadherin	37,48	Vinculin	VE-cadherin	7414	1003	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling .
26395079	0	Vinculin	42,50	Y1065	33,38	Vinculin	Y1065	7414	1149211(Tax:187410)	Gene	Gene	Bundling|compound|START_ENTITY END_ENTITY|nmod|Bundling	Correction to Phosphorylation at Y1065 in Vinculin Mediates Actin Bundling , Cell Spreading , and Mechanical Responses to Force .
24413171	0	Vinculin	0,8	zonula_occludens-1	24,42	Vinculin	zonula occludens-1	22330(Tax:10090)	21872(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Vinculin directly binds zonula_occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes .
22160571	0	Vip1p	26,31	Asf1p	65,70	Vip1p	Asf1p	851126(Tax:4932)	853327(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Inositol_phosphate kinase Vip1p interacts with histone chaperone Asf1p in Saccharomyces_cerevisiae .
16272371	0	VirB1	36,41	VirB8	121,126	VirB1	VirB8	17035749	13903651	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The putative lytic transglycosylase VirB1 from Brucella_suis interacts with the type IV secretion system core components VirB8 , VirB9 and VirB11 .
9023204	0	VirB7	16,21	VirB9	37,42	VirB7	VirB9	6382049(Tax:358)	1224326(Tax:358)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The lipoprotein VirB7 interacts with VirB9 in the membranes of Agrobacterium_tumefaciens .
22150951	0	VirB8	122,127	TcpC	24,28	VirB8	TcpC	1224325(Tax:358)	20469185	Gene	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	The conjugation protein TcpC from Clostridium_perfringens is structurally related to the type IV secretion system protein VirB8 from Gram-negative bacteria .
16272371	0	VirB8	121,126	VirB1	36,41	VirB8	VirB1	13903651	17035749	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The putative lytic transglycosylase VirB1 from Brucella_suis interacts with the type IV secretion system core components VirB8 , VirB9 and VirB11 .
9023204	0	VirB9	37,42	VirB7	16,21	VirB9	VirB7	1224326(Tax:358)	6382049(Tax:358)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The lipoprotein VirB7 interacts with VirB9 in the membranes of Agrobacterium_tumefaciens .
11952639	0	VirG	85,89	Neural_Wiskott-Aldrich_syndrome_protein	0,39	VirG	Neural Wiskott-Aldrich syndrome protein	7433	8976	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading .
11952639	0	VirG	85,89	WASP	100,104	VirG	WASP	7433	7454	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	Neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading .
21945543	0	Visfatin	0,8	ERK1/2	53,59	Visfatin	ERK1/2	297508(Tax:10116)	50689;116590	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|cells cells|nmod|END_ENTITY	Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway .
18241674	0	Visfatin	0,8	ICAM-1	18,24	Visfatin	ICAM-1	10135	3383	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells .
19751774	0	Visfatin	0,8	IL-6	43,47	Visfatin	IL-6	10135	3569	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis .
20035281	0	Visfatin	0,8	MCP-1	36,41	Visfatin	MCP-1	10135	6347	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Visfatin is a positive regulator of MCP-1 in human adipocytes in vitro and in mice in vivo .
24885580	0	Visfatin	0,8	MUC8	17,21	Visfatin	MUC8	10135	100129528	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-kB in human airway epithelial cells .
25498756	0	Visfatin	74,82	Pre-B-Cell_Colony_Enhancing_Factor	39,73	Visfatin	Pre-B-Cell Colony Enhancing Factor	10135	10113	Gene	Gene	Levels|compound|START_ENTITY END_ENTITY|dep|Levels	Nicotinamide_Phosphoribosyltransferase / Pre-B-Cell_Colony_Enhancing_Factor / Visfatin Plasma Levels and Clinical Outcome in Patients With Dilated_Cardiomyopathy .
19751774	0	Visfatin	0,8	STAT3	17,22	Visfatin	STAT3	10135	6774	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis .
21329734	0	Visfatin	0,8	mTOR	89,93	Visfatin	mTOR	10135	21977(Tax:10090)	Gene	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway .
19009499	0	Visfatin	0,8	monocyte_chemotactic_protein-1	34,64	Visfatin	monocyte chemotactic protein-1	10135	6347	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|cells cells|amod|END_ENTITY	Visfatin stimulates production of monocyte_chemotactic_protein-1 and interleukin-6 in human vein umbilical endothelial cells .
20608974	0	Visfatin	0,8	peroxisome_proliferator-activated_receptor_gamma	23,71	Visfatin	peroxisome proliferator-activated receptor gamma	10135	5468	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Visfatin is induced by peroxisome_proliferator-activated_receptor_gamma in human macrophages .
23042611	0	Visfatin	0,8	stromal_cell-derived_factor-1	17,46	Visfatin	stromal cell-derived factor-1	10135	6387	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Visfatin induces stromal_cell-derived_factor-1 expression by b1 integrin signaling in colorectal_cancer cells .
26504744	0	Vitamin-D_Receptor	50,68	VDR	70,73	Vitamin-D Receptor	VDR	7421	7421	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequency of rs731236 -LRB- Taql -RRB- , rs2228570 -LRB- Fok1 -RRB- of Vitamin-D_Receptor -LRB- VDR -RRB- gene in Emirati healthy population .
16101324	0	Vitamin-D_receptor	0,18	VDR	20,23	Vitamin-D receptor	VDR	7421	7421	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Vitamin-D_receptor -LRB- VDR -RRB- gene -LRB- Fok-I , Taq-I and Apa-I -RRB- polymorphisms in healthy individuals from north Indian population .
21228423	0	Vitamin_D-binding_protein	0,25	COPD	41,45	Vitamin D-binding protein	COPD	2638	260431	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Vitamin_D-binding_protein contributes to COPD by activation of alveolar macrophages .
16868893	0	Vitamin_D-binding_protein	0,25	DBP	27,30	Vitamin D-binding protein	DBP	2638	1628	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Vitamin_D-binding_protein -LRB- DBP -RRB- gene polymorphism is associated with Graves ' _ disease and the vitamin_D status in a Polish population study .
15820770	0	Vitamin_D-binding_protein	0,25	IA-2	61,65	Vitamin D-binding protein	IA-2	2638	5798	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	Vitamin_D-binding_protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes .
9606285	0	Vitamin_D_receptor	0,18	CAS/gp330	77,86	Vitamin D receptor	CAS/gp330	7421	9564;4036	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Vitamin_D_receptor gene polymorphism and parathyroid calcium_sensor_protein -LRB- CAS/gp330 -RRB- expression in primary_hyperparathyroidism .
12017307	0	Vitamin_D_receptor	0,18	VDR	20,23	Vitamin D receptor	VDR	7421	7421	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- expression is not a prognostic factor in cervical_cancer .
12086963	0	Vitamin_D_receptor	0,18	VDR	20,23	Vitamin D receptor	VDR	7421	7421	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- mRNA and VDR protein levels in relation to vitamin_D status , insulin secretory capacity , and VDR genotype in Bangladeshi Asians .
12168894	0	Vitamin_D_receptor	0,18	VDR	20,23	Vitamin D receptor	VDR	7421	7421	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- expression is not a prognostic factor in breast_cancer .
17121851	0	Vitamin_D_receptor	31,49	VDR	51,54	Vitamin D receptor	VDR	7421	7421	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Stress-induced c-Jun-dependent Vitamin_D_receptor -LRB- VDR -RRB- activation dissects the non-classical VDR pathway from the classical VDR activity .
20422622	0	Vitamin_D_receptor	0,18	VDR	20,23	Vitamin D receptor	VDR	7421	7421	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- gene polymorphism is associated with left ventricular -LRB- LV -RRB- mass and predicts left_ventricular_hypertrophy -LRB- LVH -RRB- progression in end-stage_renal_disease -LRB- ESRD -RRB- patients .
21659475	0	Vitamin_D_receptor	0,18	VDR	20,23	Vitamin D receptor	VDR	7421	7421	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Vitamin_D_receptor -LRB- VDR -RRB- regulation of voltage-gated chloride channels by ligands preferring a VDR-alternative pocket -LRB- VDR-AP -RRB- .
18218987	0	Vitamin_K_epoxide_reductase_complex_subunit_1	0,45	VKORC1	47,53	Vitamin K epoxide reductase complex subunit 1	VKORC1	79001	79001	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Vitamin_K_epoxide_reductase_complex_subunit_1 -LRB- VKORC1 -RRB- polymorphism and aortic_calcification : the Rotterdam Study .
26945657	0	Vitronectin	108,119	Prostate_Specific_Antigen	136,161	Vitronectin	Prostate Specific Antigen	7448	354	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Evaluation of Vitronectin Expression in Prostate_Cancer and the Clinical Significance of the Association of Vitronectin Expression with Prostate_Specific_Antigen in Detecting Prostate_Cancer .
26945657	0	Vitronectin	14,25	Prostate_Specific_Antigen	136,161	Vitronectin	Prostate Specific Antigen	7448	354	Gene	Gene	Expression|compound|START_ENTITY Evaluation|nmod|Expression Evaluation|nmod|Expression Expression|nmod|END_ENTITY	Evaluation of Vitronectin Expression in Prostate_Cancer and the Clinical Significance of the Association of Vitronectin Expression with Prostate_Specific_Antigen in Detecting Prostate_Cancer .
11290288	0	Vitronectin	0,11	Sonic_hedgehog	22,36	Vitronectin	Sonic hedgehog	7448	6469	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Vitronectin regulates Sonic_hedgehog activity during cerebellum development through CREB phosphorylation .
9667615	0	Vitronectin	0,11	plasmin	70,77	Vitronectin	plasmin	7448	5340	Gene	Gene	expression|compound|START_ENTITY expression|dep|inhibition inhibition|nmod|generation generation|compound|END_ENTITY	Vitronectin expression in rheumatoid arthritic synovia -- inhibition of plasmin generation by vitronectin produced in vitro .
23019340	0	Vitronectin	0,11	telencephalin	130,143	Vitronectin	telencephalin	7448	7087	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin .
25671694	0	Vitronectin	103,114	uPAR	27,31	Vitronectin	uPAR	7448	5329	Gene	Gene	Interaction|compound|START_ENTITY Inhibitors|nmod|Interaction uPA|dobj|Inhibitors uPA|nsubj|Class Class|nmod|END_ENTITY	A New Class of Orthosteric uPAR uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR Vitronectin Interaction .
25671694	0	Vitronectin	103,114	uPAR	97,101	Vitronectin	uPAR	7448	5329	Gene	Gene	Interaction|compound|START_ENTITY Interaction|compound|END_ENTITY	A New Class of Orthosteric uPAR uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR Vitronectin Interaction .
18708638	0	Vma13p	67,73	ATPase	97,103	Vma13p	ATPase	856148(Tax:4932)	1769	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of the N-terminal domain of subunit H -LRB- Vma13p -RRB- of the yeast vacuolar ATPase .
12437099	0	Vn	80,82	PAI-1	55,60	Vn	PAI-1	7448	5054	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- with vitronectin -LRB- Vn -RRB- : mapping the binding sites on PAI-1 and Vn .
26727366	0	Voltage-Dependent_Anion_Channel_2	27,60	VDAC2	62,67	Voltage-Dependent Anion Channel 2	VDAC2	7417	7417	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of Oyster Voltage-Dependent_Anion_Channel_2 -LRB- VDAC2 -RRB- Suggests Its Involvement in Apoptosis and Host Defense .
19801654	0	Von_Hippel-Lindau	0,17	TIS11B	41,47	Von Hippel-Lindau	TIS11B	7428	677	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Von_Hippel-Lindau gene product modulates TIS11B expression in renal_cell_carcinoma : impact on vascular_endothelial_growth_factor expression in hypoxia .
18209888	0	Von_Hippel-Lindau	26,43	VHL	45,48	Von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the Von_Hippel-Lindau -LRB- VHL -RRB- gene in a family with non-syndromic_pheochromocytoma : the importance of genetic testing .
11054685	0	Von_Hippel-Lindau	4,21	tumor-suppressor	28,44	Von Hippel-Lindau	tumor-suppressor	7428	7248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The Von_Hippel-Lindau -LRB- VHL -RRB- tumor-suppressor gene is not mutated in sporadic human colon_adenocarcinomas .
8956040	0	Von_Hippel-Lindau_disease	26,51	VHL	53,56	Von Hippel-Lindau disease	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Germline mutations in the Von_Hippel-Lindau_disease -LRB- VHL -RRB- gene in families from North America , Europe , and Japan .
15524133	0	Von_Willebrand_factor	18,39	ADAMTS-13	58,67	Von Willebrand factor	ADAMTS-13	7450	11093	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	-LSB- Activity loss of Von_Willebrand_factor cleaving protein -LRB- ADAMTS-13 -RRB- is diagnostic for primary and pregnancy-related thrombotic_thrombocytopenic_purpura -RSB- .
12729795	0	Von_Willebrand_factor	0,21	IL-8	30,34	Von Willebrand factor	IL-8	7450	3576	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	Von_Willebrand_factor targets IL-8 to Weibel-Palade_bodies in an endothelial cell line .
16793694	0	Von_Willebrand_factor	0,21	P-selectin	23,33	Von Willebrand factor	P-selectin	7450	6403	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Von_Willebrand_factor , P-selectin and fibrinogen levels in patients with acute ischaemic and haemorrhagic_stroke , and their relationship with stroke sub-type and functional outcome .
17100655	0	Von_Willebrand_factor	0,21	endothelial_nitric_oxide_synthase	32,65	Von Willebrand factor	endothelial nitric oxide synthase	7450	4846	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Von_Willebrand_factor activates endothelial_nitric_oxide_synthase in blood platelets by a glycoprotein Ib-dependent mechanism .
12195693	0	Von_Willebrand_factor	0,21	factor_VIII	32,43	Von Willebrand factor	factor VIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	Von_Willebrand_factor modulates factor_VIII immunogenicity : comparative study of different factor_VIII concentrates in a haemophilia_A mouse model .
12195693	0	Von_Willebrand_factor	0,21	factor_VIII	91,102	Von Willebrand factor	factor VIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|parataxis|concentrates concentrates|nsubj|study study|nmod|END_ENTITY	Von_Willebrand_factor modulates factor_VIII immunogenicity : comparative study of different factor_VIII concentrates in a haemophilia_A mouse model .
19786936	0	Von_Willebrand_factor	0,21	factor_VIII	22,33	Von Willebrand factor	factor VIII	7450	2157	Gene	Gene	START_ENTITY|parataxis|concentrates concentrates|nsubj|END_ENTITY	Von_Willebrand_factor / factor_VIII concentrates in the treatment of von_Willebrand disease .
15622623	0	Vp16	22,26	GM-CSF	1,7	Vp16	GM-CSF	3054	1437	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	-LSB- GM-CSF regulates the Vp16 induced leukemic cell apoptosis -RSB- .
11259200	0	Vpr	51,54	HHR23A	64,70	Vpr	HHR23A	155807(Tax:11676)	5886	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Interaction of human_immunodeficiency_virus_type_1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr .
20145198	0	Vpr	6,9	IL-6	38,42	Vpr	IL-6	155807(Tax:11676)	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency .
21519849	0	Vpr	86,89	SNF2h	18,23	Vpr	SNF2h	155807(Tax:11676)	8467	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of SNF2h , a chromatin-remodeling factor , as a novel binding protein of Vpr of human_immunodeficiency_virus_type_1 .
15063744	0	Vpr	35,38	Vpr	79,82	Vpr	Vpr	155807(Tax:11676)	155807(Tax:11676)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation .
15063744	0	Vpr	79,82	Vpr	35,38	Vpr	Vpr	155807(Tax:11676)	155807(Tax:11676)	Gene	Gene	ubiquitination|nmod|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	HIV-1 auxiliary regulatory protein Vpr promotes ubiquitination and turnover of Vpr mutants containing the L64P mutation .
22157821	0	VprBP	0,5	RAG1	24,28	VprBP	RAG1	321006(Tax:10090)	19373(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	VprBP binds full-length RAG1 and is required for B-cell development and V -LRB- D -RRB- J recombination fidelity .
22854957	0	Vps18	40,45	vacuole_protein_sorting_18	12,38	Vps18	vacuole protein sorting 18	228545(Tax:10090)	228545(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Ablation of vacuole_protein_sorting_18 -LRB- Vps18 -RRB- gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes .
12953057	0	Vps20p	0,6	Vps4p	31,36	Vps20p	Vps4p	855101(Tax:4932)	856303(Tax:4932)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces_cerevisiae .
19828734	0	Vps21	57,62	Vps8	19,23	Vps21	Vps8	854256(Tax:4932)	851261(Tax:4932)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments .
20173035	0	Vps21	11,16	Vps8	43,47	Vps21	Vps8	854256(Tax:4932)	851261(Tax:4932)	Gene	Gene	Mapping|nmod|START_ENTITY Mapping|dep|sites sites|nmod|END_ENTITY	Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking .
23843610	0	Vps36	11,16	Hedgehog	46,54	Vps36	Hedgehog	39523(Tax:7227)	42737(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|signaling signaling|compound|END_ENTITY	Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling .
16505166	0	Vps4	38,42	Vta1	85,89	Vps4	Vta1	27183	51534	Gene	Gene	ESCRTs|nmod|START_ENTITY Recycling|nmod|ESCRTs regulated|nsubjpass|Recycling regulated|nmod|region region|nmod|END_ENTITY	Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1 .
23880759	0	Vps4	53,57	Vta1	34,38	Vps4	Vta1	27183	51534	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element .
23880759	0	Vps4	66,70	Vta1	34,38	Vps4	Vta1	27183	51534	Gene	Gene	element|amod|START_ENTITY Vps4|nmod|element activation|nmod|Vps4 activation|amod|END_ENTITY	Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element .
25164817	0	Vps4	0,4	Vta1	41,45	Vps4	Vta1	27183	51534	Gene	Gene	element|amod|START_ENTITY element|nmod|END_ENTITY	Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 a7 and a9 to stimulate ATP hydrolysis .
25164817	0	Vps4	66,70	Vta1	41,45	Vps4	Vta1	27183	51534	Gene	Gene	a7|compound|START_ENTITY contacts|dobj|a7 contacts|nsubj|element element|nmod|END_ENTITY	Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 a7 and a9 to stimulate ATP hydrolysis .
11432826	0	Vps45p	0,6	Tlg2p	41,46	Vps45p	Tlg2p	852785(Tax:4932)	854142(Tax:4932)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|syntaxin syntaxin|acl|homologue homologue|dobj|END_ENTITY	Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation .
17904527	0	Vps45p	83,89	Tlg2p	32,37	Vps45p	Tlg2p	852785(Tax:4932)	854142(Tax:4932)	Gene	Gene	binding|nmod|START_ENTITY mode|nmod|binding regulated|nmod|mode regulated|nsubjpass|levels levels|nmod|END_ENTITY	Cellular levels of the syntaxin Tlg2p are regulated by a single mode of binding to Vps45p .
19667197	0	Vps45p	93,99	Tlg2p	39,44	Vps45p	Tlg2p	852785(Tax:4932)	854142(Tax:4932)	Gene	Gene	conformation|nmod|START_ENTITY binding|nmod|conformation modulates|dobj|binding modulates|nsubj|peptide peptide|nmod|END_ENTITY	The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p .
9930650	0	Vps45p	20,26	Tlg2p	49,54	Vps45p	Tlg2p	852785(Tax:4932)	854142(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The Sec1p homologue Vps45p binds to the syntaxin Tlg2p .
11432826	0	Vps45p	0,6	syntaxin	22,30	Vps45p	syntaxin	852785(Tax:4932)	851219(Tax:4932)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation .
10679028	0	Vps4p	37,42	SKD1	10,14	Vps4p	SKD1	856303(Tax:4932)	20479(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The mouse SKD1 , a homologue of yeast Vps4p , is required for normal endosomal trafficking and morphology in mammalian cells .
12953057	0	Vps4p	31,36	Vps20p	0,6	Vps4p	Vps20p	856303(Tax:4932)	855101(Tax:4932)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces_cerevisiae .
18280501	0	Vps4p	33,38	Vta1p	64,69	Vps4p	Vta1p	856303(Tax:4932)	850878(Tax:4932)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p .
12377769	0	Vps51p	0,6	Tlg1p	42,47	Vps51p	Tlg1p	853890(Tax:4932)	852079(Tax:4932)	Gene	Gene	links|nsubj|START_ENTITY links|nmod|END_ENTITY	Vps51p links the VFT complex to the SNARE Tlg1p .
20615984	0	Vps54	92,97	GARP	113,117	Vps54	GARP	245944(Tax:10090)	434215(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|complex complex|compound|END_ENTITY	Structural basis for the wobbler mouse neurodegenerative_disorder caused by mutation in the Vps54 subunit of the GARP complex .
12006663	0	Vps55p	6,12	obesity_receptor_gene-related_protein	44,81	Vps55p	obesity receptor gene-related protein	54741	54741	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Yeast Vps55p , a functional homolog of human obesity_receptor_gene-related_protein , is involved in late endosome to vacuole trafficking .
19828734	0	Vps8	19,23	Vps21	57,62	Vps8	Vps21	851261(Tax:4932)	854256(Tax:4932)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments .
20173035	0	Vps8	43,47	Vps21	11,16	Vps8	Vps21	851261(Tax:4932)	854256(Tax:4932)	Gene	Gene	sites|nmod|START_ENTITY Mapping|dep|sites Mapping|nmod|END_ENTITY	Mapping of Vps21 and HOPS binding sites in Vps8 and effect of binding site mutants on endocytic trafficking .
12654912	0	Vps9p	0,5	ubiquitin	17,26	Vps9p	ubiquitin	854876(Tax:4932)	850620(Tax:4932)	Gene	Gene	binding|compound|START_ENTITY binding|compound|END_ENTITY	Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic .
17959659	0	Vpu	36,39	CD74	63,67	Vpu	CD74	155945(Tax:11676)	972	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation .
14561767	0	Vpu	6,9	betaTrCP	64,72	Vpu	betaTrCP	155945(Tax:11676)	8945	Gene	Gene	sequesters|nsubj|START_ENTITY sequesters|dobj|END_ENTITY	HIV-1 Vpu sequesters beta-transducin_repeat-containing_protein -LRB- betaTrCP -RRB- in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates .
20386718	0	Vpu	55,58	tetherin	14,22	Vpu	tetherin	155945(Tax:11676)	684	Gene	Gene	release|nmod|START_ENTITY restriction|nmod|release restriction|compound|END_ENTITY	Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment .
22530020	0	Vpu	104,107	tetherin	17,25	Vpu	tetherin	155945(Tax:11676)	684	Gene	Gene	gene|compound|START_ENTITY presence|nmod|gene differing|nmod|presence SIVs|xcomp|differing SIVs|nsubj|Counteraction Counteraction|nmod|activity activity|amod|END_ENTITY	Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene .
23284757	0	Vpu	0,3	tetherin	40,48	Vpu	tetherin	155945(Tax:11676)	684	Gene	Gene	downmodulates|nsubj|START_ENTITY downmodulates|dobj|targets targets|appos|envelope envelope|compound|END_ENTITY	Vpu downmodulates two distinct targets , tetherin and gibbon_ape_leukemia_virus envelope , through shared features in the Vpu cytoplasmic tail .
23284757	0	Vpu	120,123	tetherin	40,48	Vpu	tetherin	155945(Tax:11676)	684	Gene	Gene	tail|compound|START_ENTITY features|nmod|tail downmodulates|nmod|features downmodulates|dobj|targets targets|appos|envelope envelope|compound|END_ENTITY	Vpu downmodulates two distinct targets , tetherin and gibbon_ape_leukemia_virus envelope , through shared features in the Vpu cytoplasmic tail .
23633949	0	Vpu	0,3	tetherin	22,30	Vpu	tetherin	155945(Tax:11676)	684	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Vpu binds directly to tetherin and displaces it from nascent virions .
24465210	0	Vpu	67,70	tetherin	16,24	Vpu	tetherin	155945(Tax:11676)	684	Gene	Gene	alleles|compound|START_ENTITY circulating|dobj|alleles counter-activities|advcl|circulating counter-activities|nsubj|Preservation Preservation|nmod|END_ENTITY	Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1_infected individuals .
11179306	0	VraA	0,4	BBI16	6,11	VraA	BBI16	1194194(Tax:224326)	1194194(Tax:224326)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	VraA -LRB- BBI16 -RRB- protein of Borrelia_burgdorferi is a surface-exposed antigen with a repetitive motif that confers partial protection against experimental Lyme_borreliosis .
16505166	0	Vta1	85,89	Vps4	38,42	Vta1	Vps4	51534	27183	Gene	Gene	region|nmod|START_ENTITY regulated|nmod|region regulated|nsubjpass|Recycling Recycling|nmod|ESCRTs ESCRTs|nmod|END_ENTITY	Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1 .
23880759	0	Vta1	34,38	Vps4	53,57	Vta1	Vps4	51534	27183	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element .
23880759	0	Vta1	34,38	Vps4	66,70	Vta1	Vps4	51534	27183	Gene	Gene	activation|amod|START_ENTITY activation|nmod|Vps4 Vps4|nmod|element element|amod|END_ENTITY	Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element .
25164817	0	Vta1	41,45	Vps4	0,4	Vta1	Vps4	51534	27183	Gene	Gene	element|nmod|START_ENTITY element|amod|END_ENTITY	Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 a7 and a9 to stimulate ATP hydrolysis .
25164817	0	Vta1	41,45	Vps4	66,70	Vta1	Vps4	51534	27183	Gene	Gene	element|nmod|START_ENTITY contacts|nsubj|element contacts|dobj|a7 a7|compound|END_ENTITY	Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 a7 and a9 to stimulate ATP hydrolysis .
18280501	0	Vta1p	64,69	Vps4p	33,38	Vta1p	Vps4p	850878(Tax:4932)	856303(Tax:4932)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p .
21388490	0	Vti1b	18,23	Syntaxin_11	0,11	Vti1b	Syntaxin 11	10490	8676	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Syntaxin_11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages .
9716255	0	W3/25	12,17	CD4	27,30	W3/25	CD4	24932(Tax:10116)	24932(Tax:10116)	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Kinetics of W3/25 anti-rat CD4 monoclonal antibody .
11102889	0	WAF-1	105,110	p16	89,92	WAF-1	p16	1026	1029	Gene	Gene	p21|appos|START_ENTITY END_ENTITY|appos|p21	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
10942587	0	WAF-1	146,151	p21	142,145	WAF-1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	TGF-beta-mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21 -LRB- WAF-1 -RRB- expression .
12917633	0	WAF-1	70,75	p21	66,69	WAF-1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Role of protein kinase C and the Sp1-p53 complex in activation of p21 -LRB- WAF-1 -RRB- expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells .
15249198	0	WAF-1	16,21	p21	0,3	WAF-1	p21	1026	1026	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	p21 -LRB- Cip-1 / SDI-1 / WAF-1 -RRB- expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells .
19738071	0	WAF-1	41,46	p21	37,40	WAF-1	p21	1026	1026	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma_and_multiple_myeloma through a LSD1-mediated epigenetic mechanism .
12782595	0	WAF1	44,48	ATM	65,68	WAF1	ATM	1026	472	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Histone deacetylase inhibitors activate p21 -LRB- WAF1 -RRB- expression via ATM .
16998811	0	WAF1	87,91	EZH2	49,53	WAF1	EZH2	1026	2146	Gene	Gene	p21|appos|START_ENTITY p16|appos|p21 analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
18762186	0	WAF1	70,74	Mist1	0,5	WAF1	Mist1	12575(Tax:10090)	17341(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Mist1 regulates pancreatic acinar cell proliferation through p21_CIP1 / WAF1 .
11700890	0	WAF1	5,9	P21	0,3	WAF1	P21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	P21 -LRB- WAF1 -RRB- expression in colorectal_cancer : correlation with P53 and cyclin_D1 expression , clinicopathological parameters and prognosis .
11700890	0	WAF1	5,9	P53	61,64	WAF1	P53	1026	7157	Gene	Gene	expression|appos|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	P21 -LRB- WAF1 -RRB- expression in colorectal_cancer : correlation with P53 and cyclin_D1 expression , clinicopathological parameters and prognosis .
16998811	0	WAF1	87,91	VEGF	43,47	WAF1	VEGF	1026	7422	Gene	Gene	p21|appos|START_ENTITY p16|appos|p21 analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
15934315	0	WAF1	38,42	cyclinD1	24,32	WAF1	cyclinD1	1026	595	Gene	Gene	p21|appos|START_ENTITY END_ENTITY|appos|p21	Expression of survivin , cyclinD1 , p21 -LRB- WAF1 -RRB- , caspase-3 in cervical_cancer and its relation with prognosis .
12383116	0	WAF1	18,22	cyclin_A	152,160	WAF1	cyclin A	1026	890	Gene	Gene	p21|appos|START_ENTITY p21|nmod|END_ENTITY	Highly potent p21 -LRB- WAF1 -RRB- - derived peptide inhibitors of CDK-mediated pRb phosphorylation : delineation and structural insight into their interactions with cyclin_A .
16998811	0	WAF1	87,91	p16	60,63	WAF1	p16	1026	1029	Gene	Gene	p21|appos|START_ENTITY END_ENTITY|appos|p21	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
10420154	0	WAF1	20,24	p21	16,19	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Relationship of p21 -LRB- WAF1 -RRB- expression with disease-free survival and biochemical recurrence in prostate_adenocarcinomas -LRB- PCa -RRB- .
10679299	0	WAF1	23,27	p21	19,22	WAF1	p21	1026	1026	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Binding domain for p21 -LRB- WAF1 -RRB- on the polypeptide chain of the protein kinase CK2_beta-subunit .
11021966	0	WAF1	70,74	p21	66,69	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Epstein-barr virus nuclear antigen 2 retards cell growth , induces p21 -LRB- WAF1 -RRB- expression , and modulates p53 activity post-translationally .
11819597	0	WAF1	122,126	p21	118,121	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Analysis of in vivo patterns of caspase_3 gene expression in primary hepatocellular_carcinoma and its relationship to p21 -LRB- WAF1 -RRB- expression and hepatic apoptosis .
11888912	0	WAF1	51,55	p21	47,50	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Perifosine , a novel alkylphospholipid , induces p21 -LRB- WAF1 -RRB- expression in squamous_carcinoma cells through a p53-independent pathway , leading to loss in cyclin-dependent kinase activity and cell cycle arrest .
12706118	0	WAF1	113,117	p21	109,112	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
12782595	0	WAF1	44,48	p21	40,43	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Histone deacetylase inhibitors activate p21 -LRB- WAF1 -RRB- expression via ATM .
12824923	0	WAF1	151,155	p21	147,150	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Enhanced sensitivity to cis-diamminedichloroplatinum -LRB- II -RRB- of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21 -LRB- WAF1 -RRB- expression .
14996726	0	WAF1	50,54	p21	46,49	WAF1	p21	1026	1026	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Tbx2 directly represses the expression of the p21 -LRB- WAF1 -RRB- cyclin-dependent kinase inhibitor .
15069711	0	WAF1	56,60	p21	52,55	WAF1	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of p21 -LRB- WAF1 -RRB- and p53 and polymorphism of p21 -LRB- WAF1 -RRB- gene in gastric_carcinoma .
15248906	0	WAF1	44,48	p21	40,43	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Effects of hepatitis_B virus X gene on p21 -LRB- WAF1 -RRB- expression through p53-dependent and p53-independent pathways -RSB- .
15302882	0	WAF1	50,54	p21	46,49	WAF1	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interplay between HIV-1 Vpr and Sp1 modulates p21 -LRB- WAF1 -RRB- gene expression in human astrocytes .
15707594	0	WAF1	16,20	p21	11,14	WAF1	p21	1026	1026	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for p21 -LRB- WAF1 -RRB- in the cAMP-dependent differentiation of F9 teratocarcinoma cells into parietal endoderm .
16383301	0	WAF1	32,36	p21	28,31	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Prognostic significance of p21 -LRB- WAF1 -RRB- expression in osteosarcoma -RSB- .
16733561	0	WAF1	50,54	p21	46,49	WAF1	p21	1026	1026	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Quantitative analysis of the level of p53 and p21 -LRB- WAF1 -RRB- mRNA in human colon_cancer HT-29 cells treated with inositol_hexaphosphate .
19343784	0	WAF1	45,49	p21	41,44	WAF1	p21	114851(Tax:10116)	24525(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Arecoline-induced phosphorylated p53 and p21 -LRB- WAF1 -RRB- protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells .
19470386	0	WAF1	97,101	p21	93,96	WAF1	p21	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Rosmarinic_acid suppresses retinal_neovascularization via cell cycle arrest with increase of p21 -LRB- WAF1 -RRB- expression .
19818775	0	WAF1	20,24	p21	16,19	WAF1	p21	1026	1026	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Let-7a elevates p21 -LRB- WAF1 -RRB- levels by targeting of NIRF and suppresses the growth of A549_lung_cancer cells .
20039273	0	WAF1	43,47	p21	39,42	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Single-cell analysis of p16 -LRB- INK4a -RRB- and p21 -LRB- WAF1 -RRB- expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni_Syndrome fibroblasts .
20398565	0	WAF1	49,53	p21	45,48	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	-LSB- Platelet-derived growth factor-BB inhibited p21 -LRB- WAF1 -RRB- expression partially through transforming_growth_factor-beta signalling system in vascular smooth muscle cell -RSB- .
21124069	0	WAF1	68,72	p21	64,67	WAF1	p21	1026	1026	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Strategies to re-express epigenetically silenced p15 -LRB- INK4b -RRB- and p21 -LRB- WAF1 -RRB- genes in acute_myeloid_leukemia .
21555914	0	WAF1	51,55	p21	47,50	WAF1	p21	1026	1026	Gene	Gene	induction|appos|START_ENTITY induction|amod|END_ENTITY	SRSF2 is required for sodium_butyrate-mediated p21 -LRB- WAF1 -RRB- induction and premature senescence in human lung_carcinoma cell lines .
21903579	0	WAF1	49,53	p21	45,48	WAF1	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	p53-independent epigenetic repression of the p21 -LRB- WAF1 -RRB- gene in T-cell_acute_lymphoblastic_leukemia .
23894605	0	WAF1	36,40	p21	32,35	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p16 -LRB- INK4A -RRB- positively regulates p21 -LRB- WAF1 -RRB- expression by suppressing AUF1-dependent mRNA decay .
7496159	0	WAF1	42,46	p21	47,50	WAF1	p21	1026	1026	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant_melanomas .
9616149	0	WAF1	18,22	p21	14,17	WAF1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of p21 -LRB- WAF1 -RRB- expression during normal myeloid differentiation .
9694869	0	WAF1	38,42	p21	34,37	WAF1	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of the p21 -LRB- WAF1 , CIP1 , SDI1 -RRB- gene by interleukin-6 type cytokines .
9722590	0	WAF1	12,16	p21	8,11	WAF1	p21	114851(Tax:10116)	24525(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Ectopic p21 -LRB- WAF1 -RRB- expression induces differentiation-specific cell cycle changes in PC12 cells characteristic of nerve growth factor treatment .
9770473	0	WAF1	27,31	p21	23,26	WAF1	p21	1026	1026	Gene	Gene	complexes|appos|START_ENTITY complexes|amod|END_ENTITY	Activity and nature of p21 -LRB- WAF1 -RRB- complexes during the cell cycle .
20701798	0	WAF1	38,42	p21_CIP1	29,37	WAF1	p21 CIP1	1026	1026	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	MiTF links Erk1/2 kinase and p21_CIP1 / WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells .
10718400	0	WAF1	36,40	p53	24,27	WAF1	p53	1026	7157	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of aberrant p53 and p21 -LRB- WAF1 -RRB- immunoreactivity with the outcome of oral_verrucous_leukoplakia in Taiwan .
10788799	0	WAF1	31,35	p53	54,57	WAF1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY p21|nmod|END_ENTITY	IL-1 induces expression of p21 -LRB- WAF1 -RRB- independently of p53 in high-passage human embryonic fibroblasts WI38 .
11080661	0	WAF1	143,147	p53	131,134	WAF1	p53	1026	7157	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	The effect of dibenzo -LSB- a ,1 -RSB- pyrene and benzo -LSB- a -RSB- pyrene on human diploid lung fibroblasts : the induction of DNA adducts , expression of p53 and p21 -LRB- WAF1 -RRB- proteins and cell cycle distribution .
11097743	0	WAF1	22,26	p53	80,83	WAF1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY induced|dobj|p21 TNF-alpha|acl|induced TNF-alpha|dep|WiDr WiDr|nmod|END_ENTITY	TNF-alpha induced p21 -LRB- WAF1 -RRB- but not Bax in colon_cancer cells WiDr with mutated p53 : important role of protein stabilization .
11395384	0	WAF1	100,104	p53	0,3	WAF1	p53	1026	7157	Gene	Gene	induction|nummod|START_ENTITY arrest|nmod|induction arrest|nsubj|localization localization|compound|END_ENTITY	p53 cellular localization and function in neuroblastoma : evidence for defective G -LRB- 1 -RRB- arrest despite WAF1 induction in MYCN-amplified cells .
11866928	0	WAF1	61,65	p53	41,44	WAF1	p53	1026	7157	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|protein protein|compound|END_ENTITY	-LSB- Expression and clinical significance of p53 protein and p21 -LRB- WAF1 -RRB- in non-small-cell lung_carcinoma -RSB- .
12034325	0	WAF1	50,54	p53	38,41	WAF1	p53	1026	7157	Gene	Gene	levels|appos|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	Acrylonitrile exposure : the effect on p53 and p21 -LRB- WAF1 -RRB- protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts .
12473386	0	WAF1	25,29	p53	13,16	WAF1	p53	1026	7157	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of p53 and p21 -LRB- WAF1 -RRB- expression on sensitivity of cancer cells to cladribine .
12706118	0	WAF1	113,117	p53	7,10	WAF1	p53	1026	7157	Gene	Gene	expression|appos|START_ENTITY reducing|dobj|expression senescing|advcl|reducing delay|advcl|senescing delay|nsubj|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
12824923	0	WAF1	151,155	p53	101,104	WAF1	p53	1026	7157	Gene	Gene	expression|appos|START_ENTITY gene|nmod|expression gene|compound|END_ENTITY	Enhanced sensitivity to cis-diamminedichloroplatinum -LRB- II -RRB- of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21 -LRB- WAF1 -RRB- expression .
15069711	0	WAF1	56,60	p53	28,31	WAF1	p53	1026	7157	Gene	Gene	gene|appos|START_ENTITY END_ENTITY|nmod|gene	Expression of p21 -LRB- WAF1 -RRB- and p53 and polymorphism of p21 -LRB- WAF1 -RRB- gene in gastric_carcinoma .
16998811	0	WAF1	87,91	p53	55,58	WAF1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY p16|appos|p21 analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17408702	0	WAF1	68,72	p53	56,59	WAF1	p53	1026	7157	Gene	Gene	proteins|appos|START_ENTITY proteins|amod|END_ENTITY	Air pollution by carcinogenic PAHs and plasma levels of p53 and p21 -LRB- WAF1 -RRB- proteins .
18828269	0	WAF1	78,82	p53	58,61	WAF1	p53	1026	7157	Gene	Gene	Bcl-XL|nummod|START_ENTITY Bcl-XL|compound|END_ENTITY	Apoptosis and adenocarcinoma_of_the_cardia : expression of p53 , Bcl-2 , Bcl-XL , WAF1 , and fas proteins and association with characteristics of the tumors .
21368573	0	WAF1	4,8	p53	70,73	WAF1	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	p21|appos|START_ENTITY component|nsubj|p21 component|nmod|loop loop|acl:relcl|maintains maintains|dobj|program program|compound|END_ENTITY	p21 -LRB- WAF1 -RRB- is component of a positive feedback loop that maintains the p53 transcriptional program .
21541527	0	WAF1	0,4	p53	34,37	WAF1	p53	1026	7157	Gene	Gene	expression|compound|START_ENTITY independent|nsubj|expression independent|nmod|alterations alterations|compound|END_ENTITY	WAF1 expression is independent of p53 gene alterations and protein expression in human lung_cancer cells .
21791360	0	WAF1	45,49	p53	82,85	WAF1	p53	1026	7157	Gene	Gene	transcription|appos|START_ENTITY transcription|nmod|END_ENTITY	Human_papillomavirus_type_16 E6 inhibits p21 -LRB- WAF1 -RRB- transcription independently of p53 by inactivating p150 -LRB- Sal2 -RRB- .
24277474	0	WAF1	40,44	p53	46,49	WAF1	p53	1026	7157	Gene	Gene	expression|appos|START_ENTITY synthase|dep|expression synthase|parataxis|identify identify|nsubj|phenotype phenotype|compound|END_ENTITY	Thymidylate synthase expression and p21 -LRB- WAF1 -RRB- / p53 phenotype of colon_cancers identify patients who may benefit from 5-fluorouracil based therapy .
27039754	0	WAF1	21,25	p53	0,3	WAF1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY END_ENTITY|appos|p21	p53 , Cyclin_D1 , p21 -LRB- WAF1 -RRB- and Ki-67 -LRB- MIB1 -RRB- Expression at Invasive Tumour Fronts of Oral_Squamous_Cell_Carcinomas and Development of Local Recurrence .
8242752	0	WAF1	0,4	p53	30,33	WAF1	p53	1026	7157	Gene	Gene	START_ENTITY|appos|mediator mediator|nmod|suppression suppression|compound|END_ENTITY	WAF1 , a potential mediator of p53 tumor suppression .
8731201	0	WAF1	92,96	p53	79,82	WAF1	p53	114851(Tax:10116)	301300(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The effect of ACE inhibitors on the expression of matrix genes and the role of p53 and p21 -LRB- WAF1 -RRB- in experimental renal fibrosis .
8749722	0	WAF1	81,85	p53	135,138	WAF1	p53	1026	7157	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|cells cells|acl|containing containing|dobj|END_ENTITY	Retrovirally mediated wild-type p53 restores S-phase modulation without inducing WAF1 mRNA in breast_carcinoma cells containing mutant p53 .
8749722	0	WAF1	81,85	p53	32,35	WAF1	p53	1026	7157	Gene	Gene	mRNA|compound|START_ENTITY inducing|dobj|mRNA restores|advcl|inducing restores|nsubj|END_ENTITY	Retrovirally mediated wild-type p53 restores S-phase modulation without inducing WAF1 mRNA in breast_carcinoma cells containing mutant p53 .
8941927	0	WAF1	24,28	p53	11,14	WAF1	p53	1026	7157	Gene	Gene	Control|appos|START_ENTITY Control|nmod|END_ENTITY	Control of p53 and p21 -LRB- WAF1 -RRB- expression during unilateral_ureteral_obstruction .
9815858	0	WAF1	8,12	p53	98,101	WAF1	p53	1026	7157	Gene	Gene	genes|compound|START_ENTITY play|nsubj|genes play|nmod|breast_cancers breast_cancers|acl|lacking lacking|dobj|mutations mutations|compound|END_ENTITY	Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast_cancers lacking p53 mutations .
9334807	0	WAF1/CIP1	35,44	bcl-2	20,25	WAF1/CIP1	bcl-2	1026	596	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between bcl-2 and p21 -LRB- WAF1/CIP1 -RRB- in breast_carcinomas with wild-type p53 .
10485911	0	WAF1/CIP1	29,38	p21	25,28	WAF1/CIP1	p21	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The lack of a functional p21 -LRB- WAF1/CIP1 -RRB- gene ameliorates progression to chronic_renal_failure .
10782880	0	WAF1/CIP1	32,41	p21	27,30	WAF1/CIP1	p21	1026	1026	Gene	Gene	p53|appos|START_ENTITY p53|appos|END_ENTITY	Protein expression of p53 , p21 -LRB- WAF1/CIP1 -RRB- , bcl-2 , Bax , cyclin_D1 and pRb in human colon_carcinomas .
10883667	0	WAF1/CIP1	12,21	p21	8,11	WAF1/CIP1	p21	1026	1026	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Reduced p21 -LRB- WAF1/CIP1 -RRB- protein expression is predominantly related to altered p53 in hepatocellular_carcinomas .
11064455	0	WAF1/CIP1	26,35	p21	21,24	WAF1/CIP1	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sp1 and Sp3 activate p21 -LRB- WAF1/CIP1 -RRB- gene transcription in the Caco-2 colon_adenocarcinoma cell line .
11274368	0	WAF1/CIP1	22,31	p21	18,21	WAF1/CIP1	p21	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Myc represses the p21 -LRB- WAF1/CIP1 -RRB- promoter and interacts with Sp1/Sp3 .
11842244	0	WAF1/CIP1	87,96	p21	83,86	WAF1/CIP1	p21	1026	1026	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	The hinge region of the human papillomavirus type 8 E2_protein activates the human p21 -LRB- WAF1/CIP1 -RRB- promoter via interaction with Sp1 .
19895794	0	WAF1/CIP1	29,38	p21	25,28	WAF1/CIP1	p21	1026	1026	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Nuclear translocation of p21 -LRB- WAF1/CIP1 -RRB- protein prior to its cytosolic degradation by UV enhances DNA repair and survival .
24005533	0	WAF1/CIP1	43,52	p21	38,41	WAF1/CIP1	p21	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aberrant promoter hypermethylation of p21 -LRB- WAF1/CIP1 -RRB- gene and its impact on expression and role of polymorphism in the risk of breast_cancer .
25483783	0	WAF1/CIP1	22,31	p21	17,20	WAF1/CIP1	p21	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	ANKHD1 represses p21 -LRB- WAF1/CIP1 -RRB- promoter and promotes multiple_myeloma cell growth .
8831553	0	WAF1/CIP1	5,14	p21	0,3	WAF1/CIP1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line .
8883416	0	WAF1/CIP1	19,28	p21	14,17	WAF1/CIP1	p21	1026	1026	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Expression of p21 -LRB- WAF1/CIP1 -RRB- protein in clinical thyroid tissues .
9194578	0	WAF1/CIP1	60,69	p21	56,59	WAF1/CIP1	p21	1026	1026	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/CIP1 -RRB- in human cutaneous malignant_melanoma .
10712385	0	WAF1/CIP1	9,18	p53	0,3	WAF1/CIP1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY END_ENTITY|appos|p21	p53 , p21 -LRB- WAF1/CIP1 -RRB- , and MDM2 involvement in proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells .
10764661	0	WAF1/CIP1	9,18	p53	0,3	WAF1/CIP1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY END_ENTITY|appos|p21	p53 , p21 -LRB- WAF1/CIP1 -RRB- , and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells .
11212250	0	WAF1/cip1	33,42	p21	29,32	WAF1/cip1	p21	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Targeted inactivation of the p21 -LRB- WAF1/cip1 -RRB- gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal .
18654788	0	WAFL	44,48	WASP_and_FKBP-like	24,42	WAFL	WASP and FKBP-like	23307	7454	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Identification of a new WASP_and_FKBP-like -LRB- WAFL -RRB- protein in inflammatory_bowel_disease : a potential marker gene for ulcerative_colitis .
7527372	0	WAGR	2,6	PAX-6	27,32	WAGR	PAX-6	5080	5080	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	A WAGR region gene between PAX-6 and FSHB expressed in fetal brain .
17401362	0	WAH-1	32,37	SCRM-1	133,139	WAH-1	SCRM-1	176635(Tax:6239)	173053(Tax:6239)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	C. _ elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1 .
11326419	0	WAP	103,106	whey_acidic_protein	82,101	WAP	whey acidic protein	22373(Tax:10090)	22373(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A transgenic mouse model for investigating the response of the upstream region of whey_acidic_protein -LRB- WAP -RRB- gene to various steroid hormones .
17692477	0	WAP	47,50	whey_acidic_protein	26,45	WAP	whey acidic protein	396835(Tax:9823)	396835(Tax:9823)	Gene	Gene	control|appos|START_ENTITY control|nmod|END_ENTITY	Distal control of the pig whey_acidic_protein -LRB- WAP -RRB- locus in transgenic_mice .
7576607	0	WAP	35,38	whey_acidic_protein	14,33	WAP	whey acidic protein	22373(Tax:10090)	22373(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Expression of whey_acidic_protein -LRB- WAP -RRB- genes in tissues other than the mammary gland in normal and transgenic_mice expressing mWAP/hGH fusion gene .
26928556	0	WAP_four-disulfide_core_domain_protein_2	0,40	WFDC2	46,51	WAP four-disulfide core domain protein 2	WFDC2	10406	10406	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	WAP_four-disulfide_core_domain_protein_2 gene -LRB- WFDC2 -RRB- is a target of estrogen in ovarian_cancer cells .
20971096	0	WARP	35,39	Willebrand_A_domain-related_protein	45,80	WARP	Willebrand A domain-related protein	64856	64856	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Immunocytochemical distribution of WARP -LRB- von Willebrand_A_domain-related_protein -RRB- in the inner ear .
8646895	0	WARS	59,63	tryptophanyl-tRNA_synthetase	24,52	WARS	tryptophanyl-tRNA synthetase	7453	7453	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Assignment of the human tryptophanyl-tRNA_synthetase gene -LRB- WARS -RRB- to chromosome 14q32 .2 -- > q32 .32 .
23318438	0	WASF3	0,5	ZEB1	40,44	WASF3	ZEB1	10810	6935	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast_cancer cells .
24980959	0	WASH	21,25	RNF2	0,4	WASH	RNF2	653440	6045	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy .
25213142	0	WASP	24,28	Btk	50,53	WASP	Btk	7454	695	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Specific binding of the WASP N-terminal domain to Btk is critical for TLR2 signaling in macrophages .
17296785	0	WASP	0,4	CD25	61,65	WASP	CD25	7454	16184(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	WASP regulates suppressor activity of human and murine CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- FOXP3 -LRB- + -RRB- natural regulatory T cells .
17302440	0	WASP	27,31	Cdc42	46,51	WASP	Cdc42	7454	998	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of WASP and N-WASP by Cdc42 , Rac1 , Nck , and PI -LRB- 4,5 -RRB- P2 .
11952639	0	WASP	100,104	VirG	85,89	WASP	VirG	7454	7433	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	Neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading .
17312144	0	WASP	63,67	WASP_interacting_protein	74,98	WASP	WASP interacting protein	7454	7456	Gene	Gene	Requirement|appos|START_ENTITY Requirement|nmod|END_ENTITY	Requirement for a complex of Wiskott-Aldrich_syndrome protein -LRB- WASP -RRB- with WASP_interacting_protein in podosome formation in macrophages .
18654788	0	WASP_and_FKBP-like	24,42	WAFL	44,48	WASP and FKBP-like	WAFL	7454	23307	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of a new WASP_and_FKBP-like -LRB- WAFL -RRB- protein in inflammatory_bowel_disease : a potential marker gene for ulcerative_colitis .
17312144	0	WASP_interacting_protein	74,98	WASP	63,67	WASP interacting protein	WASP	7456	7454	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|appos|END_ENTITY	Requirement for a complex of Wiskott-Aldrich_syndrome protein -LRB- WASP -RRB- with WASP_interacting_protein in podosome formation in macrophages .
19234535	0	WASp	36,40	Hck	11,14	WASp	Hck	7454	3055	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils .
16606694	0	WASp	21,25	WIP	15,18	WASp	WIP	7454	7456	Gene	Gene	Formation|dep|START_ENTITY Formation|nmod|END_ENTITY	Formation of a WIP - , WASp - , actin - , and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling .
11748279	0	WASp	66,70	intersectin_2	4,17	WASp	intersectin 2	7454	50618	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The intersectin_2 adaptor links Wiskott Aldrich_Syndrome protein -LRB- WASp -RRB- - mediated actin polymerization to T_cell_antigen_receptor endocytosis .
26496209	0	WAVE1	48,53	CB1	25,28	WAVE1	CB1	83767(Tax:10090)	12801(Tax:10090)	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons .
21281239	0	WAVE1	0,5	Ezrin	46,51	WAVE1	Ezrin	8936	7430	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells .
21281239	0	WAVE1	0,5	P-glycoprotein	16,30	WAVE1	P-glycoprotein	8936	5243	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	WAVE1 regulates P-glycoprotein expression via Ezrin in leukemia cells .
16260607	0	WAVE1	65,70	Sra-1	59,64	WAVE1	Sra-1	8936	23191	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1 / WAVE1 complex and axon formation .
18701695	0	WAVE2	24,29	Cdk5	0,4	WAVE2	Cdk5	10163	1020	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn .
18701695	0	WAVE2	24,29	Fyn	117,120	WAVE2	Fyn	10163	2534	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn .
19576655	0	WAVE2	106,111	HSPC300	69,76	WAVE2	HSPC300	10163	55845	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Metastatic potential of lung_squamous_cell_carcinoma associated with HSPC300 through its interaction with WAVE2 .
26396677	0	WAVE2	19,24	MiR-146a	0,8	WAVE2	MiR-146a	242687(Tax:10090)	387164(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	MiR-146a activates WAVE2 expression and enhances phagocytosis in lipopolysaccharide-stimulated RAW264 .7 macrophages .
26490115	0	WAVE2	42,47	PLCb3	0,5	WAVE2	PLCb3	10163	5331	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	PLCb3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration .
16272576	0	WAVE3	0,5	LDOC1	43,48	WAVE3	LDOC1	10810	23641	Gene	Gene	functions|nummod|START_ENTITY functions|nmod|END_ENTITY	WAVE3 functions as a negative regulator of LDOC1 .
14531730	0	WBP-2	0,5	Pax8	93,97	WBP-2	Pax8	23558	7849	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	WBP-2 , a WW domain binding protein , interacts with the thyroid-specific transcription factor Pax8 .
18928784	0	WC1	25,28	CD25	69,73	WC1	CD25	751809(Tax:9913)	281861(Tax:9913)	Gene	Gene	gammadelta|compound|START_ENTITY Subpopulations|nmod|gammadelta T|nsubj|Subpopulations T|nmod|Foxp3 Foxp3|compound|END_ENTITY	Subpopulations of bovine WC1 -LRB- + -RRB- gammadelta T cells rather than CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- Foxp3 -LRB- + -RRB- T cells act as immune regulatory cells ex vivo .
22708352	0	WC1	31,34	CD25	16,20	WC1	CD25	751809(Tax:9913)	281861(Tax:9913)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	The presence of CD25 on bovine WC1 + gammadelta T cells is positively correlated with their production of IL-10 and TGF-beta , but not IFN-gamma .
10527417	0	WCK-1	43,48	mitogen-activated_protein_kinase	66,98	WCK-1	mitogen-activated protein kinase	542829(Tax:4565)	543088(Tax:4565)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elicitor - and A23187-induced expression of WCK-1 , a gene encoding mitogen-activated_protein_kinase in wheat .
26713495	0	WD40-repeat_protein_62	28,50	Aurora_A	0,8	WD40-repeat protein 62	Aurora A	233064(Tax:10090)	20878(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Aurora_A phosphorylation of WD40-repeat_protein_62 in mitotic spindle regulation .
27026195	0	WDFY1	57,62	NRP2	0,4	WDFY1	NRP2	57590	8828	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	NRP2 transcriptionally regulates its downstream effector WDFY1 .
20189988	0	WDFY2	70,75	Akt	31,34	WDFY2	Akt	115825	207	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2 .
20971078	0	WDFY3	95,100	sequestosome-1	31,45	WDFY3	sequestosome-1	23001	8878	Gene	Gene	interaction|dep|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction between sequestosome-1 / p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts .
12115702	0	WDR1	0,4	ADF	22,25	WDR1	ADF	422842(Tax:9031)	396539(Tax:9031)	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	WDR1 colocalizes with ADF and actin in the normal and noise-damaged chick cochlea .
23333389	0	WDR18	20,25	TopBP1	44,50	WDR18	TopBP1	57418	11073	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling .
24145035	0	WDR48	18,23	USP12	55,60	WDR48	USP12	57599	219333	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH_domain_leucine-rich_repeat_protein_phosphatase_1 -LRB- PHLPP1 -RRB- .
22523547	0	WDR5	49,53	SRY	22,25	WDR5	SRY	11091	6736	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of SRY and its direct target , WDR5 , on Sox9 expression .
24388750	0	WDR62	32,37	JNK1	69,73	WDR62	JNK1	284403	5599	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex .
21777625	0	WDR68	64,69	DYRK1A	0,6	WDR68	DYRK1A	10238	1859	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation .
22491477	0	WDR83	33,38	DHPS	76,80	WDR83	DHPS	84292	1725	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric_cancer .
23512946	0	WDTC1	38,43	adipose	29,36	WDTC1	adipose	23038	230796(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Adipose tissue expression of adipose -LRB- WDTC1 -RRB- gene is associated with lower fat mass and enhanced insulin sensitivity in humans .
25247294	0	WEE1	71,75	CHD5	32,36	WEE1	CHD5	7465	26038	Gene	Gene	Repressor|nmod|START_ENTITY Repressor|nsubj|END_ENTITY	The Chromatin Remodeling Factor CHD5 Is a Transcriptional Repressor of WEE1 .
24536047	0	WEE1	36,40	HuR	0,3	WEE1	HuR	7465	1994	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	HuR posttranscriptionally regulates WEE1 : implications for the DNA damage response in pancreatic_cancer cells .
23816136	0	WEE1	27,31	miR-381	0,7	WEE1	miR-381	7465	494330	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	miR-381 , a novel intrinsic WEE1 inhibitor , sensitizes renal_cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O .
12839961	0	WFDC2	9,14	HE4	4,7	WFDC2	HE4	10406	10406	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The HE4 -LRB- WFDC2 -RRB- protein is a biomarker for ovarian_carcinoma .
26928556	0	WFDC2	46,51	WAP_four-disulfide_core_domain_protein_2	0,40	WFDC2	WAP four-disulfide core domain protein 2	10406	10406	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	WAP_four-disulfide_core_domain_protein_2 gene -LRB- WFDC2 -RRB- is a target of estrogen in ovarian_cancer cells .
23035048	0	WFS1	82,86	Wolfram_syndrome_1	62,80	WFS1	Wolfram syndrome 1	7466	7466	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Vacuolar-type H + - ATPase V1A subunit is a molecular partner of Wolfram_syndrome_1 -LRB- WFS1 -RRB- protein , which regulates its expression and stability .
25274773	0	WFS1	90,94	Wolfram_syndrome_1	70,88	WFS1	Wolfram syndrome 1	7466	7466	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Sarco -LRB- endo -RRB- plasmic reticulum ATPase -LRB- SERCA -RRB- is a molecular partner of Wolfram_syndrome_1 -LRB- WFS1 -RRB- protein , which negatively regulates its expression .
19523951	0	WFS1	48,52	wolframin	37,46	WFS1	wolframin	7466	22393(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the diabetes risk gene wolframin -LRB- WFS1 -RRB- in the human retina .
26823012	0	WHAMM	14,19	Rab1	0,4	WHAMM	Rab1	123720	5861	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Rab1 recruits WHAMM during membrane remodeling but limits actin nucleation .
24118380	0	WIF-1	76,81	HOTAIR	0,6	WIF-1	HOTAIR	11197	100124700	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	HOTAIR , a prognostic factor in esophageal_squamous_cell_carcinoma , inhibits WIF-1 expression and activates Wnt pathway .
19174556	0	WIF1	0,4	SKP2	41,45	WIF1	SKP2	11197	6502	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	WIF1 , a Wnt pathway inhibitor , regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder_cancer cells .
26614997	0	WIF1	23,27	TIMP-3	126,132	WIF1	TIMP-3	11197	7078	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Abnormal expression of WIF1 in hepatocellular_carcinoma cells and its regulating effect on invasion and metastasis factors of TIMP-3 and caveolin-1 of hepatocellular_carcinoma .
16501252	0	WIF1	41,45	Wnt_inhibitory_factor-1	16,39	WIF1	Wnt inhibitory factor-1	11197	11197	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inactivation of Wnt_inhibitory_factor-1 -LRB- WIF1 -RRB- expression by epigenetic silencing is a common event in breast_cancer .
25681036	0	WIF1	76,80	miR-603	0,7	WIF1	miR-603	11197	693188	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	miR-603 promotes glioma cell growth via Wnt/b-catenin pathway by inhibiting WIF1 and CTNNBIP1 .
11689294	0	WIG-1	46,51	PAG608	52,58	WIG-1	PAG608	64393	3499451(Tax:1359)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|dep|localization	Cloning and chromosomal localization of human WIG-1 / PAG608 and demonstration of amplification with increased expression in primary squamous_cell_carcinoma_of_the_lung .
12620186	0	WIP	25,28	Cortactin	0,9	WIP	Cortactin	7456	2017	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion .
10706671	0	WIP	14,17	Vav	91,94	WIP	Vav	7456	7409	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Cutting edge : WIP , a binding partner for Wiskott-Aldrich_syndrome protein , cooperates with Vav in the regulation of T cell activation .
16606694	0	WIP	15,18	WASp	21,25	WIP	WASp	7456	7454	Gene	Gene	Formation|nmod|START_ENTITY Formation|dep|END_ENTITY	Formation of a WIP - , WASp - , actin - , and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling .
23871434	0	WIP1	0,4	HIPK2	73,78	WIP1	HIPK2	53892(Tax:10090)	15258(Tax:10090)	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	WIP1 , a homeostatic regulator of the DNA damage response , is targeted by HIPK2 for phosphorylation and degradation .
25797250	0	WIP1	0,4	MMP-9	88,93	WIP1	MMP-9	8493	4318	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|advcl|inducing inducing|dobj|END_ENTITY	WIP1 stimulates migration and invasion of salivary adenoid_cystic_carcinoma by inducing MMP-9 and VEGF-C .
19200887	0	WIPI-1	33,39	Atg18	40,45	WIPI-1	Atg18	55062	55062	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Assessing mammalian autophagy by WIPI-1 / Atg18 puncta formation .
16539846	0	WISH	103,107	IL-28	18,23	WISH	IL-28	51517	282617	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells .
16539846	0	WISH	103,107	IL-28	84,89	WISH	IL-28	51517	282617	Gene	Gene	cells|compound|START_ENTITY IL-28|nmod|cells IL-28|nmod|END_ENTITY	Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells .
16019439	0	WISH	109,113	vascular_endothelial_growth_factor	55,89	WISH	vascular endothelial growth factor	51517	7422	Gene	Gene	cells|appos|START_ENTITY END_ENTITY|nmod|cells	The effect of epidermal_growth_factor on production of vascular_endothelial_growth_factor by amnion-derived -LRB- WISH -RRB- cells .
20684029	0	WISP-1	0,6	CCN4	7,11	WISP-1	CCN4	8840	8840	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	WISP-1 / CCN4 regulates osteogenesis by enhancing BMP-2 activity .
21453685	0	WISP-1	0,6	MMP-2	17,22	WISP-1	MMP-2	8840	4313	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells .
15706414	0	WISP-2	88,94	CCN5	95,99	WISP-2	CCN5	22403(Tax:10090)	22403(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Stimulation of MCF-7 tumor progression in athymic nude_mice by 17beta-estradiol induces WISP-2 / CCN5 expression in xenografts : a novel signaling molecule in hormonal carcinogenesis .
15798095	0	WISP-2	32,38	CCN5	39,43	WISP-2	CCN5	8839	8839	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Epidermal_growth_factor induces WISP-2 / CCN5 expression in estrogen_receptor-alpha-positive breast_tumor cells through multiple molecular cross-talks .
18070926	0	WISP-2	8,14	CCN5	15,19	WISP-2	CCN5	8839	8839	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of WISP-2 / CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast_cancer cells .
15798095	0	WISP-2	32,38	Epidermal_growth_factor	0,23	WISP-2	Epidermal growth factor	8839	1950	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces WISP-2 / CCN5 expression in estrogen_receptor-alpha-positive breast_tumor cells through multiple molecular cross-talks .
19339243	0	WISP1	0,5	tumor_necrosis_factor-alpha	54,81	WISP1	tumor necrosis factor-alpha	8840	7124	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	WISP1 , a pro-mitogenic , pro-survival factor , mediates tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- - stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte_death .
16457688	0	WISP3	20,25	CCN6	14,18	WISP3	CCN6	8838	8838	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Inhibition of CCN6 -LRB- WISP3 -RRB- expression promotes neoplastic progression and enhances the effects of insulin-like_growth_factor-1 on breast epithelial cells .
15664193	0	WISp39	42,48	p21	14,17	WISp39	p21	63943	1026	Gene	Gene	stability|nmod|START_ENTITY stability|amod|END_ENTITY	Regulation of p21 -LRB- WAF1/CIP1 -RRB- stability by WISp39 , a Hsp90 binding TPR protein .
14681216	0	WNK1	0,4	ERK5	15,19	WNK1	ERK5	65125	5598	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	WNK1 activates ERK5 by an MEKK2/3-dependent mechanism .
20937822	0	WNK1	15,19	GLUT1	76,81	WNK1	GLUT1	65125	6513	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2 / USP6-BUB2-Cdc16_domain_family_member_4 -LRB- TBC1D4 -RRB- - Rab8A complex .
19363035	0	WNK1	23,27	LINGO-1	0,7	WNK1	LINGO-1	65125	84894	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LINGO-1 interacts with WNK1 to regulate nogo-induced inhibition of neurite extension .
25362046	0	WNK1	30,34	OSR1	109,113	WNK1	OSR1	65125	9943	Gene	Gene	Actions|nmod|START_ENTITY mediated|nsubjpass|Actions mediated|nmod|END_ENTITY	Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK .
22119528	0	WNK1	0,4	PIP	14,17	WNK1	PIP	65125	5304	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|synthesis synthesis|compound|END_ENTITY	WNK1 promotes PIP synthesis to coordinate growth factor and GPCR-Gq signaling .
16428287	0	WNK1	60,64	ROMK	27,31	WNK1	ROMK	65125	3758	Gene	Gene	isoforms|compound|START_ENTITY regulation|nmod|isoforms regulation|nmod|END_ENTITY	Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms .
16775035	0	WNK1	0,4	ROMK	39,43	WNK1	ROMK	65125	3758	Gene	Gene	affects|nsubj|START_ENTITY affects|dobj|expression expression|nmod|independent independent|compound|END_ENTITY	WNK1 affects surface expression of the ROMK potassium channel independent of WNK4 .
19244242	0	WNK1	65,69	ROMK	14,18	WNK1	ROMK	232341(Tax:10090)	56379(Tax:10090)	Gene	Gene	kinase|compound|START_ENTITY homeostasis|nmod|kinase homeostasis|nsubj|Regulation Regulation|nmod|channel channel|compound|END_ENTITY	Regulation of ROMK channel and K + homeostasis by kidney-specific WNK1 kinase .
21355052	0	WNK1	99,103	ROMK	51,55	WNK1	ROMK	65125	3758	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1 .
16006511	0	WNK1	0,4	SGK1	15,19	WNK1	SGK1	65125	6446	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	WNK1 activates SGK1 to regulate the epithelial sodium channel .
16081417	0	WNK1	0,4	SGK1	15,19	WNK1	SGK1	65125	6446	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism .
20813867	0	WNK1	14,18	miR-192	33,40	WNK1	miR-192	65125	406967	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of WNK1 expression by miR-192 and aldosterone .
15350218	0	WNK1	0,4	synaptotagmin_2	20,35	WNK1	synaptotagmin 2	65125	127833	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	WNK1 phosphorylates synaptotagmin_2 and modulates its membrane binding .
18593598	0	WNK2	0,4	MEK1	15,19	WNK2	MEK1	65268	5604	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	WNK2 modulates MEK1 activity through the Rho GTPase pathway .
22114204	0	WNK4	0,4	ERK1/2	50,56	WNK4	ERK1/2	69847(Tax:10090)	26417;26413	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway .
16775035	0	WNK4	77,81	ROMK	39,43	WNK4	ROMK	65266	3758	Gene	Gene	independent|nmod|START_ENTITY independent|compound|END_ENTITY	WNK1 affects surface expression of the ROMK potassium channel independent of WNK4 .
17360471	0	WNK4	16,20	SGK1	3,7	WNK4	SGK1	65266	6446	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	An SGK1 site in WNK4 regulates Na + channel and K + channel activity and has implications for aldosterone signaling and K + homeostasis .
26707142	0	WNT-1	82,87	MicroRNA-148a	0,13	WNT-1	MicroRNA-148a	7471	406940	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-148a inhibits breast_cancer migration and invasion by directly targeting WNT-1 .
15870927	0	WNT-1	10,15	beta-catenin	19,31	WNT-1	beta-catenin	7471	1499	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral_squamous_cell_carcinoma .
10944466	0	WNT-13	35,41	WNT-2B	28,34	WNT-13	WNT-2B	7482	7482	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Alternative splicing of the WNT-2B / WNT-13 gene .
10944466	0	WNT-2B	28,34	WNT-13	35,41	WNT-2B	WNT-13	7482	7482	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Alternative splicing of the WNT-2B / WNT-13 gene .
22647544	0	WNT-5A	35,41	ERK1/2	55,61	WNT-5A	ERK1/2	22418(Tax:10090)	26417;26413	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation .
23727359	0	WNT-5A	0,6	ERK1/2	47,53	WNT-5A	ERK1/2	7474	5595;5594	Gene	Gene	triggers|nsubj|START_ENTITY triggers|nmod|decrease decrease|amod|dependent dependent|advmod|END_ENTITY	WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast_cancer cells .
25578861	0	WNT/b-catenin	17,30	FOXO3a	0,6	WNT/b-catenin	FOXO3a	1499	2309	Gene	Gene	signaling|amod|START_ENTITY modulates|dobj|signaling modulates|nsubj|END_ENTITY	FOXO3a modulates WNT/b-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate_cancer cells .
26189775	0	WNT/b-catenin	55,68	Ubiquitin_specific_protease_4	0,29	WNT/b-catenin	Ubiquitin specific protease 4	1499	7375	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Ubiquitin_specific_protease_4 positively regulates the WNT/b-catenin signaling in colorectal_cancer .
11494032	0	WNT10A	17,23	tumor_necrosis_factor_alpha	27,54	WNT10A	tumor necrosis factor alpha	80326	7124	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of WNT10A by tumor_necrosis_factor_alpha and Helicobacter_pylori in gastric_cancer .
12239602	0	WNT10B	133,139	WNT10B	70,76	WNT10B	WNT10B	7480	7480	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Expression and regulation of WNT10B in human cancer : up-regulation of WNT10B in MCF-7 cells by beta-estradiol and down-regulation of WNT10B in NT2 cells by retinoic_acid .
12239602	0	WNT10B	70,76	WNT10B	133,139	WNT10B	WNT10B	7480	7480	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Expression and regulation of WNT10B in human cancer : up-regulation of WNT10B in MCF-7 cells by beta-estradiol and down-regulation of WNT10B in NT2 cells by retinoic_acid .
20107203	0	WNT2	0,4	beta-catenin	62,74	WNT2	beta-catenin	22413(Tax:10090)	12387(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	WNT2 regulates DNA synthesis in mouse granulosa cells through beta-catenin .
19895723	0	WNT2	101,105	wingless-type_MMTV_integration_site_family_member_2	47,98	WNT2	wingless-type MMTV integration site family member 2	7472	7472	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association between autism and variants in the wingless-type_MMTV_integration_site_family_member_2 -LRB- WNT2 -RRB- gene .
16368545	0	WNT3A	112,117	matrix_metalloproteinase-13_and_tissue_inhibitor_of_matrix_metalloproteinase-1	14,92	WNT3A	matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1	22416(Tax:10090)	17386(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of matrix_metalloproteinase-13_and_tissue_inhibitor_of_matrix_metalloproteinase-1 gene expression by WNT3A and bone_morphogenetic_protein-2 in osteoblastic differentiation .
23142810	0	WNT4	0,4	BMP2	24,28	WNT4	BMP2	54361	650	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	WNT4 acts downstream of BMP2 and functions via b-catenin signaling pathway to regulate human endometrial stromal cell differentiation .
16368682	0	WNT4	15,19	PAX2	0,4	WNT4	PAX2	54361	5076	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	PAX2 activates WNT4 expression during mammalian kidney development .
17227781	0	WNT5A	0,5	CUTL1	17,22	WNT5A	CUTL1	7474	1523	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	WNT5A -- target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic_cancer .
19048125	0	WNT5A	0,5	PAX2	22,26	WNT5A	PAX2	7474	5076	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms_tumorigenesis .
22040971	0	WNT5A	43,48	RUNX1	1,6	WNT5A	RUNX1	22418(Tax:10090)	12394(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	-LSB- RUNX1 regulates transcription activity of WNT5A in mouse bone marrow derived mesenchymal stem cells -RSB- .
22370641	0	WNT6	0,4	caveolin-1	31,41	WNT6	caveolin-1	7475	857	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric_cancer cells .
24497849	0	WNT7B	0,5	mTORC1	46,52	WNT7B	mTORC1	22422(Tax:10090)	382056(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	WNT7B promotes bone formation in part through mTORC1 .
12937339	0	WNT7a	0,5	E-cadherin	14,24	WNT7a	E-cadherin	7476	999	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	WNT7a induces E-cadherin in lung_cancer cells .
11894124	0	WRCH1	14,19	WRCH1	59,64	WRCH1	WRCH1	58480	58480	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells .
11894124	0	WRCH1	59,64	WRCH1	14,19	WRCH1	WRCH1	58480	58480	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of WRCH1 in human cancer and down-regulation of WRCH1 by beta-estradiol in MCF-7 cells .
21070409	0	WRINKLED1	18,27	PII	0,3	WRINKLED1	PII	824599(Tax:3702)	828213(Tax:3702)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	PII is induced by WRINKLED1 and fine-tunes fatty_acid composition in seeds of Arabidopsis_thaliana .
18776063	0	WRKY38	12,18	histone_deacetylase_19	66,88	WRKY38	histone deacetylase 19	832320(Tax:3702)	829969(Tax:3702)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	Arabidopsis WRKY38 and WRKY62 transcription factors interact with histone_deacetylase_19 in basal defense .
20802463	0	WRN	33,36	ATR	0,3	WRN	ATR	7486	545	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery .
21123451	0	WRN	19,22	BCR/ABL	0,7	WRN	BCR/ABL	7486	25	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	BCR/ABL stimulates WRN to promote survival and genomic instability .
26391948	0	WRN	79,82	PARP1	38,43	WRN	PARP1	7486	142	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential and concordant roles for PARP1 and poly -LRB- ADP-ribose -RRB- in regulating WRN and RECQL5 activities .
12750383	0	WRN	0,3	RAD52	82,87	WRN	RAD52	7486	5893	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	WRN interacts physically and functionally with the recombination mediator protein RAD52 .
11498731	0	WRN	46,49	Werner_helicase	29,44	WRN	Werner helicase	7486	7486	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A polymorphic variant at the Werner_helicase -LRB- WRN -RRB- gene is associated with bone density , but not spondylosis , in postmenopausal women .
15735006	0	WRN	48,51	helicase	52,60	WRN	helicase	7486	164045	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	p53 modulates RPA-dependent and RPA-independent WRN helicase activity .
21220316	0	WRN	86,89	helicase	14,22	WRN	helicase	7486	164045	Gene	Gene	Werner_syndrome_helicase|appos|START_ENTITY function|nsubj|Werner_syndrome_helicase impairs|ccomp|function impairs|nsubj|Inhibition Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of helicase activity by a small molecule impairs Werner_syndrome_helicase -LRB- WRN -RRB- function in the cellular response to DNA damage or replication stress .
26808708	0	WRN	23,26	helicase	27,35	WRN	helicase	7486	164045	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nsubj|inhibition	Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA .
15735006	0	WRN	48,51	p53	0,3	WRN	p53	7486	7157	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	p53 modulates RPA-dependent and RPA-independent WRN helicase activity .
23792163	0	WSB-1	15,20	HIF1	0,4	WSB-1	HIF1	26118	3091	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular_carcinoma cells .
23085504	0	WSTF	85,89	CYP19A1	99,106	WSTF	CYP19A1	9031	1588	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Vitamin_D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase .
25452584	0	WSTF	74,78	VDR	47,50	WSTF	VDR	9031	7421	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Retraction : ` Ligand-induced transrepression by VDR through association of WSTF with acetylated histones ' .
12734330	0	WSX-1	28,33	IL-27	22,27	WSX-1	IL-27	9466	246778	Gene	Gene	signaling|nsubj|START_ENTITY edge|parataxis|signaling edge|dep|role role|nmod|END_ENTITY	Cutting edge : role of IL-27 / WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment .
14764690	0	WSX-1	0,5	IL-27	72,77	WSX-1	IL-27	9466	246778	Gene	Gene	constitute|nsubj|START_ENTITY constitute|dobj|receptor receptor|nmod|END_ENTITY	WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 .
15494513	0	WSX-1	20,25	IL-27	4,9	WSX-1	IL-27	50931(Tax:10090)	246779(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The IL-27 receptor -LRB- WSX-1 -RRB- is an inhibitor of innate and adaptive elements of type 2 immunity .
15850576	0	WSX-1	33,38	IL-27	0,5	WSX-1	IL-27	9466	246778	Gene	Gene	subunits|appos|START_ENTITY subunits|compound|END_ENTITY	IL-27 subunits and its receptor -LRB- WSX-1 -RRB- mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental_autoimmune_encephalomyelitis .
16306766	0	WSX-1	38,43	IL-27	32,37	WSX-1	IL-27	50931(Tax:10090)	246779(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY required|nsubjpass|signaling property|parataxis|required property|nmod|END_ENTITY	T helper 1-inducing property of IL-27 / WSX-1 signaling is required for the induction of experimental colitis .
16920482	0	WSX-1	75,80	IL-27	48,53	WSX-1	IL-27	9466	246778	Gene	Gene	START_ENTITY|amod|alpha alpha|amod|END_ENTITY	Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1 .
19354069	0	WSX-1	109,114	IL-27	103,108	WSX-1	IL-27	50931(Tax:10090)	246779(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY Amelioration|parataxis|signaling Amelioration|nmod|responses responses|nmod|lack lack|nmod|END_ENTITY	Amelioration of experimental_allergic_rhinitis with suppression of topical immune responses by lack of IL-27 / WSX-1 signaling .
12734330	0	WSX-1	28,33	T-bet	61,66	WSX-1	T-bet	9466	30009	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|induction induction|nmod|END_ENTITY	Cutting edge : role of IL-27 / WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment .
23832418	0	WT1	28,31	CD95L	41,46	WT1	CD95L	7490	356	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	The Wilms ' _ tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic_T cells .
19082485	0	WT1	20,23	Cyclin_A1	0,9	WT1	Cyclin A1	7490	8900	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cyclin_A1 regulates WT1 expression in acute_myeloid_leukemia cells .
10753894	0	WT1	16,19	E-cadherin	0,10	WT1	E-cadherin	22431(Tax:10090)	12550(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	E-cadherin is a WT1 target gene .
12151099	0	WT1	40,43	FHL2	25,29	WT1	FHL2	7490	2274	Gene	Gene	activity|nummod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation .
25804736	0	WT1	0,3	Gas1	12,16	WT1	Gas1	22431(Tax:10090)	14451(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals .
25232865	0	WT1	0,3	MAD2	19,23	WT1	MAD2	7490	4085	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	WT1 interacts with MAD2 and regulates mitotic checkpoint function .
10047468	0	WT1	72,75	Ornithine_decarboxylase	0,23	WT1	Ornithine decarboxylase	7490	4953	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Ornithine_decarboxylase is a transcriptional target of tumor suppressor WT1 .
14580722	0	WT1	0,3	P450arom	43,51	WT1	P450arom	7490	1588	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells .
11852808	0	WT1	16,19	P53	53,56	WT1	P53	7490	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|regulation regulation|nmod|proteins proteins|compound|END_ENTITY	-LSB- Involvement of WT1 gene expression in regulation of P53 and MDM2 proteins function in acute_lymphoblastic_leukemia -RSB- .
9388203	0	WT1	22,25	PAX_8	0,5	WT1	PAX 8	7490	7849	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	PAX_8 regulates human WT1 transcription through a novel DNA binding site .
21658388	0	WT1	57,60	PKCa	90,94	WT1	PKCa	7490	5578	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Inhibitory mechanism of pure curcumin on Wilms ' _ tumor_1 -LRB- WT1 -RRB- gene expression through the PKCa signaling pathway in leukemic K562 cells .
11719225	0	WT1	0,3	Podocalyxin	79,90	WT1	Podocalyxin	7490	5420	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin .
16934801	0	WT1	0,3	RBM4	40,44	WT1	RBM4	7490	5936	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo .
11278460	0	WT1	57,60	SRY	31,34	WT1	SRY	7490	6736	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The human sex-determining gene SRY is a direct target of WT1 .
12970737	0	WT1	107,110	SRY	54,57	WT1	SRY	7490	6736	Gene	Gene	product|appos|START_ENTITY modulated|nmod|product modulated|nsubjpass|activity activity|nmod|END_ENTITY	Transcriptional activity of testis-determining factor SRY is modulated by the Wilms ' _ tumor_1 gene product , WT1 .
22815844	0	WT1	104,107	SRY	66,69	WT1	SRY	7490	6736	Gene	Gene	mutation|compound|START_ENTITY END_ENTITY|advcl|mutation	A 46 , XY female DSD patient with bilateral gonadoblastoma , a novel SRY missense mutation combined with a WT1 KTS splice-site mutation .
9879712	0	WT1	30,33	SRY	109,112	WT1	SRY	22431(Tax:10090)	21674(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY function|nsubj|gene function|nmod|line line|acl|transfected transfected|nmod|END_ENTITY	Wilms ' _ tumor suppressor gene -LRB- WT1 -RRB- as a target gene of SRY function in a mouse ES cell line transfected with SRY .
9879712	0	WT1	30,33	SRY	55,58	WT1	SRY	22431(Tax:10090)	21674(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|nmod|gene gene|nmod|END_ENTITY	Wilms ' _ tumor suppressor gene -LRB- WT1 -RRB- as a target gene of SRY function in a mouse ES cell line transfected with SRY .
12130543	0	WT1	27,30	Sf1	82,85	WT1	Sf1	7490	7536	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	The Wilms_tumor suppressor WT1 regulates early gonad development by activation of Sf1 .
19549635	0	WT1	27,30	Sry	45,48	WT1	Sry	22431(Tax:10090)	21674(Tax:10090)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	A cell-autonomous role for WT1 in regulating Sry in vivo .
25601757	0	WT1	0,3	TET2	13,17	WT1	TET2	7490	54790	Gene	Gene	Recruits|compound|START_ENTITY END_ENTITY|nsubj|Recruits	WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress_Leukemia Cell Proliferation .
12681485	0	WT1	49,52	TauT	40,44	WT1	TauT	7490	6533	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of taurine transporter gene -LRB- TauT -RRB- by WT1 .
9784496	0	WT1	0,3	U2AF65	39,45	WT1	U2AF65	7490	11338	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes .
26597595	0	WT1	72,75	Wilms_Tumor-1	57,70	WT1	Wilms Tumor-1	7490	7490	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	A 4-gene expression score associated with high levels of Wilms_Tumor-1 -LRB- WT1 -RRB- expression is an adverse prognostic factor in acute_myeloid_leukaemia .
25881478	0	WT1	15,18	Wilms_tumor_1	0,13	WT1	Wilms tumor 1	7490	7490	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Wilms_tumor_1 -LRB- WT1 -RRB- protein : Diagnostic utility in pediatric_tumors .
7559553	0	WT1	32,35	c-myb	18,23	WT1	c-myb	7490	4602	Gene	Gene	protein|compound|START_ENTITY gene|nmod|protein gene|amod|END_ENTITY	Repression of the c-myb gene by WT1 protein in T and B cell lines .
23936312	0	WT1	0,3	cyclin_D1	95,104	WT1	cyclin D1	22431(Tax:10090)	12443(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	WT1 promotes cell proliferation in non-small cell lung_cancer cell lines through up-regulating cyclin_D1 and p-pRb in vitro and in vivo .
22737185	0	WT1	97,100	estrogen_receptor-a	23,42	WT1	estrogen receptor-a	7490	2099	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Opposite regulation of estrogen_receptor-a and its variant ER-a36 by the Wilms ' _ tumor suppressor WT1 .
16924231	0	WT1	32,35	hnRNP-U	0,7	WT1	hnRNP-U	7490	3192	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation .
7553624	0	WT1	0,3	insulin-like_growth_factor_2	26,54	WT1	insulin-like growth factor 2	7490	3481	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	WT1 induces expression of insulin-like_growth_factor_2 in Wilms ' _ tumor cells .
8175666	0	WT1	111,114	insulin-like_growth_factor_I_receptor	34,71	WT1	insulin-like growth factor I receptor	100767732	100768531	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|gene gene|amod|END_ENTITY	Transcriptional repression of the insulin-like_growth_factor_I_receptor -LRB- IGF-I-R -RRB- gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site .
8873895	0	WT1	99,102	insulin-like_growth_factor_I_receptor	14,51	WT1	insulin-like growth factor I receptor	7490	3480	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of insulin-like_growth_factor_I_receptor gene expression by the Wilms ' _ tumor suppressor WT1 .
12841384	0	WT1	59,62	lck	4,7	WT1	lck	22431(Tax:10090)	16818(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The lck promoter-driven expression of the Wilms_tumor gene WT1 blocks intrathymic differentiation of T-lineage cells .
9446634	0	WT1	48,51	leukemia_inhibitory_factor	71,97	WT1	leukemia inhibitory factor	22431(Tax:10090)	16878(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY upregulated|nsubjpass|Expression upregulated|nmod|END_ENTITY	Expression of the Wilms ' _ tumor suppressor gene , WT1 , is upregulated by leukemia_inhibitory_factor and induces monocytic differentiation in M1 leukemic cells .
9719458	0	WT1	45,48	mdr-1	20,25	WT1	mdr-1	7490	5243	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|amod|END_ENTITY	p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines .
18644985	0	WT1	0,3	mitogen-activated_protein_kinase_phosphatase_3	17,63	WT1	mitogen-activated protein kinase phosphatase 3	7490	1848	Gene	Gene	induction|nummod|START_ENTITY induction|nmod|END_ENTITY	WT1 induction of mitogen-activated_protein_kinase_phosphatase_3 represents a novel mechanism of growth suppression .
15504938	0	WT1	0,3	nephrin	71,78	WT1	nephrin	7490	4868	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|enhancer enhancer|acl|identified identified|nmod|gene gene|compound|END_ENTITY	WT1 activates a glomerular-specific enhancer identified from the human nephrin gene .
15579507	0	WT1	97,100	nephrin	27,34	WT1	nephrin	22431(Tax:10090)	54631(Tax:10090)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The major podocyte protein nephrin is transcriptionally activated by the Wilms ' _ tumor suppressor WT1 .
8604351	0	WT1	85,88	ornithine_decarboxylase	14,37	WT1	ornithine decarboxylase	7490	4953	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of ornithine_decarboxylase gene expression by the Wilms ' _ tumor suppressor WT1 .
9108440	0	WT1	53,56	p21	13,16	WT1	p21	7490	1026	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of p21 by the Wilms ' _ tumor suppressor gene WT1 .
10634423	0	WT1	82,85	p53	44,47	WT1	p53	7490	7157	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulated expression and potential roles of p53 and Wilms ' _ tumor suppressor gene -LRB- WT1 -RRB- during follicular development in the human ovary .
24490140	0	WT1	46,49	p53	59,62	WT1	p53	7490	7157	Gene	Gene	derived|nmod|START_ENTITY peptide|acl|derived enhances|nsubj|peptide enhances|dobj|activity activity|compound|END_ENTITY	A novel cell-penetrating peptide derived from WT1 enhances p53 activity , induces cell senescence and displays antimelanoma activity in xeno - and syngeneic systems .
7657166	0	WT1	4,7	p53	32,35	WT1	p53	7490	7157	Gene	Gene	product|compound|START_ENTITY stabilizes|nsubj|product stabilizes|dobj|END_ENTITY	The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis .
9072005	0	WT1	0,3	p53	79,82	WT1	p53	7490	7157	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|END_ENTITY	WT1 mutation in malignant_mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression , cell-type transition , and prognosis .
9719458	0	WT1	45,48	p53	0,3	WT1	p53	7490	7157	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene mediate|dobj|expression mediate|nsubj|END_ENTITY	p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines .
7535092	0	WT1	36,39	platelet-derived_growth_factor_A	103,135	WT1	platelet-derived growth factor A	7490	5154	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Expression of the Wilms ' _ tumor gene WT1 in human malignant_mesothelioma cell lines and relationship to platelet-derived_growth_factor_A and insulin-like_growth_factor_2 expression .
17127464	0	WT1	95,98	vascular_endothelial_growth_factor	14,48	WT1	vascular endothelial growth factor	7490	7422	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor , VEGF , gene promoter by the tumor suppressor , WT1 .
17426708	0	WTH3	0,4	p53	31,34	WTH3	p53	84084	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|protein protein|compound|END_ENTITY	WTH3 is a direct target of the p53 protein .
23333300	0	WTX	15,18	Stat3	0,5	WTX	Stat3	139285	6774	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Stat3 inhibits WTX expression through up-regulation of microRNA-370 in Wilms_tumor .
24308844	0	WWOX	35,39	ErbB4	60,65	WWOX	ErbB4	51741	2066	Gene	Gene	binding|nmod|START_ENTITY suppressor|amod|binding suppressor|nmod|tyrosine tyrosine|amod|END_ENTITY	Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase .
11719429	0	WWOX	0,4	FRA16D	10,16	WWOX	FRA16D	51741	2463	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	WWOX , the FRA16D gene , behaves as a suppressor of tumor growth .
23765596	0	WWOX	56,60	FRA16D	32,38	WWOX	FRA16D	51741	2463	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells .
19047365	0	WWP1	24,28	HER4	49,53	WWP1	HER4	11059	2066	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation .
18501710	0	WWP1	27,31	ubiquitin_ligase	4,20	WWP1	ubiquitin ligase	420212(Tax:9031)	422131(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The ubiquitin_ligase gene -LRB- WWP1 -RRB- is responsible for the chicken muscular_dystrophy .
25356737	0	WWP2	39,43	Notch3	71,77	WWP2	Notch3	11060	4854	Gene	Gene	START_ENTITY|nmod|Signaling Signaling|compound|END_ENTITY	Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian_Cancer .
19274063	0	WWP2	0,4	OCT4	50,54	WWP2	OCT4	11060	5460	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	WWP2 promotes degradation of transcription factor OCT4 in human embryonic_stem cells .
25266661	0	WWP2	73,77	Paip1	0,5	WWP2	Paip1	80014	10605	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Paip1 , an effective stimulator of translation initiation , is targeted by WWP2 for ubiquitination and degradation .
25568256	0	WWP2	99,103	Paip1	26,31	WWP2	Paip1	11060	10605	Gene	Gene	Targeted|nmod|START_ENTITY Targeted|nsubjpass|END_ENTITY	Correction for Lv et al. , Paip1 , an Effective Stimulator of Translation Initiation , Is Targeted by WWP2 for Ubiquitination and Degradation .
23479606	0	WWP2	10,14	TRIF	86,90	WWP2	TRIF	66894(Tax:10090)	106759(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation .
15221015	0	WW_domain-containing_protein_1	79,109	transforming_growth_factor-beta	23,54	WW domain-containing protein 1	transforming growth factor-beta	11059	7040	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of transforming_growth_factor-beta -LRB- TGF-beta -RRB- signaling by WW_domain-containing_protein_1 -LRB- WWP1 -RRB- .
18724389	0	WW_domain_containing_E3_ubiquitin_protein_ligase_1	4,54	ErbB2	67,72	WW domain containing E3 ubiquitin protein ligase 1	ErbB2	11059	2064	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	The WW_domain_containing_E3_ubiquitin_protein_ligase_1 upregulates ErbB2 and EGFR through RING_finger_protein_11 .
19561640	0	WW_domain_containing_E3_ubiquitin_protein_ligase_1	0,50	ErbB4	75,80	WW domain containing E3 ubiquitin protein ligase 1	ErbB4	11059	2066	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	WW_domain_containing_E3_ubiquitin_protein_ligase_1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast_cancer .
18724389	0	WW_domain_containing_E3_ubiquitin_protein_ligase_1	4,54	RING_finger_protein_11	90,112	WW domain containing E3 ubiquitin protein ligase 1	RING finger protein 11	11059	26994	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|END_ENTITY	The WW_domain_containing_E3_ubiquitin_protein_ligase_1 upregulates ErbB2 and EGFR through RING_finger_protein_11 .
23799152	0	WW_domain_containing_E3_ubiquitin_protein_ligase_1	0,50	TNF-a	93,98	WW domain containing E3 ubiquitin protein ligase 1	TNF-a	11059	7124	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	WW_domain_containing_E3_ubiquitin_protein_ligase_1 -LRB- WWP1 -RRB- negatively regulates TLR4-mediated TNF-a and IL-6 production by proteasomal degradation of TNF_receptor_associated_factor_6 -LRB- TRAF6 -RRB- .
15094066	0	Waf1	70,74	Sp1	0,3	Waf1	Sp1	1026	6667	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Sp1 is involved in the transcriptional activation of p16 -LRB- INK4 -RRB- by p21 -LRB- Waf1 -RRB- in HeLa cells .
10585285	0	Waf1	56,60	p21	52,55	Waf1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	IGF-II enhances trichostatin_A-induced TGFbeta1 and p21 -LRB- Waf1 , Cip1 , sdi1 -RRB- expression in Hep3B cells .
12651158	0	Waf1	77,81	p53	104,107	Waf1	p53	1026	7157	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Prolonged progestin treatment induces the promoter of CDK inhibitor p21 Cip1 , Waf1 through activation of p53 in human breast and endometrial_tumor cells .
12925527	0	Waf1	63,67	p53	51,54	Waf1	p53	1026	7157	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	IFI16 as a negative regulator in the regulation of p53 and p21 -LRB- Waf1 -RRB- .
19576891	0	Wallerian_degeneration	65,87	SOCS1	46,51	Wallerian degeneration	SOCS1	22406(Tax:10090)	12703(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression and potential role of SOCS1 and SOCS3 in Wallerian_degeneration in injured peripheral nerve .
2186946	0	Wap	49,52	whey_acidic_protein	28,47	Wap	whey acidic protein	22373(Tax:10090)	22373(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Induction of the endogenous whey_acidic_protein -LRB- Wap -RRB- gene and a Wap-myc hybrid gene in primary murine mammary organoids .
23901111	0	Wapl	26,30	Aurora_B	0,8	Wapl	Aurora B	23063	9212	Gene	Gene	activation|compound|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	Aurora_B and Cdk1 mediate Wapl activation and release of acetylated cohesin from chromosomes by phosphorylating Sororin .
21311569	0	Wbp2	0,4	Yorkie	21,27	Wbp2	Yorkie	39460(Tax:7227)	37851(Tax:7227)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway .
11585773	0	Wee1	52,56	Cables	0,6	Wee1	Cables	7465	91768	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1 , inhibits cell growth , and is lost in many human colon_and_squamous_cancers .
23051732	0	Wee1	23,27	Cdc14A	6,12	Wee1	Cdc14A	7465	8556	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation .
15589158	0	Wee1	11,15	Cdk1	33,37	Wee1	Cdk1	33965(Tax:7227)	34411(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis .
11251070	0	Wee1	23,27	Chk1	31,35	Wee1	Chk1	398017(Tax:8355)	398191(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive regulation of Wee1 by Chk1 and 14-3-3 proteins .
20519952	0	Wee1	23,27	Hsp90	0,5	Wee1	Hsp90	853252(Tax:4932)	855836(Tax:4932)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Hsp90 phosphorylation , Wee1 and the cell cycle .
26531472	0	Wee1	0,4	beta4GalT-VII	20,33	Wee1	beta4GalT-VII	7465	11285	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Wee1 interacts with beta4GalT-VII in neuronal development .
11498731	0	Werner_helicase	29,44	WRN	46,49	Werner helicase	WRN	7486	7486	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphic variant at the Werner_helicase -LRB- WRN -RRB- gene is associated with bone density , but not spondylosis , in postmenopausal women .
11027336	0	Werner_protein	0,14	DNA_polymerase_delta	24,44	Werner protein	DNA polymerase delta	7486	5424	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Werner_protein recruits DNA_polymerase_delta to the nucleolus .
17611195	0	Werner_syndrome_protein	10,33	NEIL1	104,109	Werner syndrome protein	NEIL1	7486	79661	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|nmod|END_ENTITY	The human Werner_syndrome_protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1 .
19664290	0	Wfs1	34,38	Wolframin	23,32	Wfs1	Wolframin	22393(Tax:10090)	22393(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Male mice with deleted Wolframin -LRB- Wfs1 -RRB- gene have reduced fertility .
21031341	0	Wfs1	79,83	wolframin	68,77	Wfs1	wolframin	22393(Tax:10090)	22393(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sex differences in the development of diabetes in mice with deleted wolframin -LRB- Wfs1 -RRB- gene .
24710642	0	Wfs1	71,75	wolframin	60,69	Wfs1	wolframin	22393(Tax:10090)	22393(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Energy metabolism and thyroid function of mice with deleted wolframin -LRB- Wfs1 -RRB- gene .
11880648	0	WhiB3	27,32	RpoV	48,52	WhiB3	RpoV	887598(Tax:83332)	887477(Tax:83332)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mycobacterium_tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth .
22048959	0	Whirlin	0,7	espin	23,28	Whirlin	espin	73750(Tax:10090)	56226(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Whirlin interacts with espin and modulates its actin-regulatory function : an insight into the mechanism of Usher_syndrome_type_II .
25188294	0	Whsc1	39,44	Runx2	73,78	Whsc1	Runx2	7468	860	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|association association|nmod|END_ENTITY	Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes .
21928342	0	Wif-1	19,24	CTGF	40,44	Wif-1	CTGF	24117(Tax:10090)	14219(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity .
18586116	0	Wif1	45,49	Wnt_inhibitor_factor_1	22,44	Wif1	Wnt inhibitor factor 1	24117(Tax:10090)	24117(Tax:10090)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of Wnt_inhibitor_factor_1 -LRB- Wif1 -RRB- during the development in mouse CNS .
24632949	0	Wif1	42,46	Wnt_inhibitory_factor_1	17,40	Wif1	Wnt inhibitory factor 1	11197	11197	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Dysregulation of Wnt_inhibitory_factor_1 -LRB- Wif1 -RRB- expression resulted in aberrant Wnt-b-catenin signaling and cell death of the cloaca endoderm , and anorectal_malformations .
20971096	0	Willebrand_A_domain-related_protein	45,80	WARP	35,39	Willebrand A domain-related protein	WARP	64856	64856	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Immunocytochemical distribution of WARP -LRB- von Willebrand_A_domain-related_protein -RRB- in the inner ear .
15543136	0	Williams_syndrome_transcription_factor	4,42	PCNA	58,62	Williams syndrome transcription factor	PCNA	9031	5111	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Williams_syndrome_transcription_factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci .
26597595	0	Wilms_Tumor-1	57,70	WT1	72,75	Wilms Tumor-1	WT1	7490	7490	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	A 4-gene expression score associated with high levels of Wilms_Tumor-1 -LRB- WT1 -RRB- expression is an adverse prognostic factor in acute_myeloid_leukaemia .
25881478	0	Wilms_tumor_1	0,13	WT1	15,18	Wilms tumor 1	WT1	7490	7490	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Wilms_tumor_1 -LRB- WT1 -RRB- protein : Diagnostic utility in pediatric_tumors .
15523622	0	Wilson_disease	72,86	ATP7B	93,98	Wilson disease	ATP7B	540	540	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotype-phenotype correlations for a wide spectrum of mutations in the Wilson_disease gene -LRB- ATP7B -RRB- .
16798742	0	Wip1	146,150	Chk2	138,142	Wip1	Chk2	8493	11200	Gene	Gene	required|nmod|START_ENTITY required|nmod|regulation regulation|nmod|END_ENTITY	Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1 .
19754813	0	Wip1	117,121	SIRT2	34,39	Wip1	SIRT2	8493	22933	Gene	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1 .
22405851	0	Wip1	67,71	wild-type_p53-induced_phosphatase_1	30,65	Wip1	wild-type p53-induced phosphatase 1	8493	8493	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	p53-Independent expression of wild-type_p53-induced_phosphatase_1 -LRB- Wip1 -RRB- in methylmethane_sulfonate-treated cancer cell lines and human tumors .
10756097	0	Wip1	79,83	wildtype_p53-induced_phosphatase_1	43,77	Wip1	wildtype p53-induced phosphatase 1	53892(Tax:10090)	8493	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The structure and expression of the murine wildtype_p53-induced_phosphatase_1 -LRB- Wip1 -RRB- gene .
19741094	0	Wiskott-Aldrich_syndrome_protein	102,134	Cdc42	0,5	Wiskott-Aldrich syndrome protein	Cdc42	7454	998	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Cdc42 regulates Fc_gamma_receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich_syndrome_protein -LRB- WASP -RRB- and neural-WASP .
12658361	0	Wkl1	45,49	Mlc1	39,43	Wkl1	Mlc1	170790(Tax:10090)	170790(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The genomic organization of the murine Mlc1 -LRB- Wkl1 , KIAA0027 -RRB- gene .
11751577	0	Wnt	35,38	JNK	0,3	Wnt	JNK	32838(Tax:7227)	44801(Tax:7227)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates .
23200852	0	Wnt	30,33	MeCP2	0,5	Wnt	MeCP2	114487(Tax:10116)	29386(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY modulates|dobj|activation modulates|nsubj|END_ENTITY	MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid_arthritis fibroblast-like synoviocytes in rats .
23908081	0	Wnt	56,59	SFRP4	36,41	Wnt	SFRP4	114487(Tax:10116)	89803(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY expression|nmod|-RSB- expression|compound|END_ENTITY	-LSB- Chuju total flavonoids control the SFRP4 expression in Wnt pathway in rheumatoid_arthritis model rats -RSB- .
20056134	0	Wnt	51,54	TCF-4	83,88	Wnt	TCF-4	114487(Tax:10116)	84382(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Insulin alters the expression of components of the Wnt signaling pathway including TCF-4 in the intestinal cells .
18789926	0	Wnt	17,20	TGFbeta	0,7	Wnt	TGFbeta	114487(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	TGFbeta promotes Wnt expression during cataract development .
15151990	0	Wnt	49,52	nemo-like_kinase	0,16	Wnt	nemo-like kinase	35975(Tax:7227)	38890(Tax:7227)	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	nemo-like_kinase is an essential co-activator of Wnt signaling during early zebrafish development .
11324569	0	Wnt-1	27,32	P19	48,51	Wnt-1	P19	22408(Tax:10090)	83430(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Neural differentiation of Wnt-1 overexpression P19 cells -RSB- .
7958454	0	Wnt-1	134,139	P19	85,88	Wnt-1	P19	22408(Tax:10090)	83430(Tax:10090)	Gene	Gene	perturbs|amod|START_ENTITY properties|amod|perturbs overexpression|nmod|properties expression|dep|overexpression expression|nmod|members members|nmod|differentiation differentiation|nmod|cells cells|compound|END_ENTITY	Regulated expression of Wnt family members during neuroectodermal differentiation of P19 embryonal_carcinoma cells : overexpression of Wnt-1 perturbs normal differentiation-specific properties .
8302595	0	Wnt-1	60,65	P19	79,82	Wnt-1	P19	22408(Tax:10090)	83430(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|cells cells|compound|END_ENTITY	Identification and biochemical characterization of secreted Wnt-1 protein from P19 embryonal_carcinoma cells induced to differentiate along the neuroectodermal lineage .
25277191	0	Wnt-1-induced_secreted_protein_1	19,51	VCAM-1	62,68	Wnt-1-induced secreted protein 1	VCAM-1	8840	7412	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Osteoblast-derived Wnt-1-induced_secreted_protein_1 increases VCAM-1 expression and enhances prostate_cancer metastasis by down-regulating miR-126 .
18321996	0	Wnt-1-induced_signaling_protein_3	20,53	CCN6	14,18	Wnt-1-induced signaling protein 3	CCN6	8838	8838	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of CCN6 -LRB- Wnt-1-induced_signaling_protein_3 -RRB- down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1 .
22294415	0	Wnt-1-inducible_signaling_pathway_protein_3	67,110	CCN6	111,115	Wnt-1-inducible signaling pathway protein 3	CCN6	8838	8838	Gene	Gene	regulation|nmod|START_ENTITY regulation|parataxis|END_ENTITY	Dual regulation of metalloproteinase expression in chondrocytes by Wnt-1-inducible_signaling_pathway_protein_3 / CCN6 .
12138115	0	Wnt-2	27,32	Frizzled-9	0,10	Wnt-2	Frizzled-9	7472	266608(Tax:10116)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta _ - catenin signaling .
10884377	0	Wnt-3	48,53	cyclooxygenase-2	14,30	Wnt-3	cyclooxygenase-2	7473	5743	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells .
18667431	0	Wnt-3a	45,51	Chondroitin_4-O-sulfotransferase-1	0,34	Wnt-3a	Chondroitin 4-O-sulfotransferase-1	22416(Tax:10090)	58250(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Chondroitin_4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate .
16425220	0	Wnt-3a	27,33	Sfrp-1	37,43	Wnt-3a	Sfrp-1	395396(Tax:9031)	395237(Tax:9031)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Differential inhibition of Wnt-3a by Sfrp-1 , Sfrp-2 , and Sfrp-3 .
21123170	0	Wnt-3a	93,99	chondroitin_4-O-sulfotransferase-1	19,53	Wnt-3a	chondroitin 4-O-sulfotransferase-1	22416(Tax:10090)	58250(Tax:10090)	Gene	Gene	diffusion|nmod|START_ENTITY triggers|dobj|diffusion triggers|nsubj|Down-regulation Down-regulation|nmod|signaling signaling|amod|END_ENTITY	Down-regulation of chondroitin_4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a .
10747853	0	Wnt-3a	83,89	microphthalmia-associated_transcription_factor	33,79	Wnt-3a	microphthalmia-associated transcription factor	89780	4286	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of melanocyte-specific microphthalmia-associated_transcription_factor by Wnt-3a .
19793883	0	Wnt-4	16,21	Notch	0,5	Wnt-4	Notch	54361	394367(Tax:8355)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros .
9853965	0	Wnt-4	26,31	sFRP-2	0,6	Wnt-4	sFRP-2	22417(Tax:10090)	20319(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney .
25454492	0	Wnt-5a	23,29	ICAM-1	56,62	Wnt-5a	ICAM-1	7474	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Human placenta-derived Wnt-5a induces the expression of ICAM-1 and VCAM-1 in CD133 -LRB- + -RRB- CD34 -LRB- + -RRB- - hematopoietic progenitor cells .
12697065	0	Wnt-5a	61,67	Stromelysin-1_and_mesothelin	0,28	Wnt-5a	Stromelysin-1 and mesothelin	7474	10232	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Stromelysin-1_and_mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells .
15802269	0	Wnt-7a	0,6	matrix_metalloproteinase-12	20,47	Wnt-7a	matrix metalloproteinase-12	7476	4321	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Wnt-7a up-regulates matrix_metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing .
9118219	0	Wnt-8	80,85	Frzb	0,4	Wnt-8	Frzb	397970(Tax:8355)	734982(Tax:8355)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Frzb , a secreted protein expressed in the Spemann organizer , binds and inhibits Wnt-8 .
21443457	0	Wnt1	35,39	Akt1	54,58	Wnt1	Akt1	7471	207	Gene	Gene	START_ENTITY|acl:relcl|requires requires|dobj|END_ENTITY	EPO relies upon novel signaling of Wnt1 that requires Akt1 , FoxO3a , GSK-3b , and b-catenin to foster vascular integrity during experimental diabetes .
25721714	0	Wnt1	0,4	CD36	26,30	Wnt1	CD36	7471	948	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-y in Macrophages .
18086577	0	Wnt1	15,19	Pax3	0,4	Wnt1	Pax3	7471	5077	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Pax3 regulates Wnt1 expression via a conserved binding site in the 5 ' proximal promoter .
25721714	0	Wnt1	0,4	TCF4	46,50	Wnt1	TCF4	7471	6925	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-y in Macrophages .
26108893	0	Wnt1	44,48	TGF-b	11,16	Wnt1	TGF-b	22408(Tax:10090)	21803(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY END_ENTITY|dobj|Secretion	Osteoclast TGF-b Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation .
26108893	0	Wnt1	44,48	TGF-b	11,16	Wnt1	TGF-b	22408(Tax:10090)	21803(Tax:10090)	Gene	Gene	Secretion|compound|START_ENTITY END_ENTITY|dobj|Secretion	Osteoclast TGF-b Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation .
17988238	0	Wnt1	98,102	beta-catenin	74,86	Wnt1	beta-catenin	24881(Tax:10116)	84353(Tax:10116)	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells .
12612606	0	Wnt1	0,4	cyclin_D1	22,31	Wnt1	cyclin D1	7471	595	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Wnt1 and Wnt5a induce cyclin_D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells .
17286598	0	Wnt10a	0,6	dentin_sialophosphoprotein	17,43	Wnt10a	dentin sialophosphoprotein	22409(Tax:10090)	666279(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Wnt10a regulates dentin_sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis .
23861379	0	Wnt10b	14,20	TGF-b	0,5	Wnt10b	TGF-b	22410(Tax:10090)	21803(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TGF-b induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts .
19213727	0	Wnt11	0,5	R-spondin_2	64,75	Wnt11	R-spondin 2	7481	340419	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Wnt11 promotes osteoblast maturation and mineralization through R-spondin_2 .
12062050	0	Wnt11	42,47	Rho_kinase_2	10,22	Wnt11	Rho kinase 2	791595(Tax:7955)	321070(Tax:7955)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Zebrafish Rho_kinase_2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements .
17081734	0	Wnt11	22,27	Tbx16	0,5	Wnt11	Tbx16	791595(Tax:7955)	30264(Tax:7955)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer .
18602094	0	Wnt11	56,61	Wnt11b	68,74	Wnt11	Wnt11b	395562(Tax:9031)	100170842(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene , Wnt11b , regulates cell migration during avian gastrulation .
25713299	0	Wnt11	115,120	p120-catenin	8,20	Wnt11	p120-catenin	22411(Tax:10090)	12388(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression .
18602094	0	Wnt11b	68,74	Wnt11	56,61	Wnt11b	Wnt11	100170842(Tax:9031)	395562(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Non-canonical Wnt signaling through Wnt5a/b and a novel Wnt11 gene , Wnt11b , regulates cell migration during avian gastrulation .
25142463	0	Wnt11r	81,87	Tbx1	0,4	Wnt11r	Tbx1	30283(Tax:7955)	368206(Tax:7955)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a .
26093292	0	Wnt16	0,5	Wnt5a	63,68	Wnt16	Wnt5a	93735(Tax:10090)	22418(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a .
22873724	0	Wnt1_inducible_signaling_pathway_protein_1	0,42	PRAS40	59,65	Wnt1 inducible signaling pathway protein 1	PRAS40	8840	84335	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Wnt1_inducible_signaling_pathway_protein_1 -LRB- WISP1 -RRB- targets PRAS40 to govern b-amyloid apoptotic injury of microglia .
16621466	0	Wnt2	0,4	GATA6	38,43	Wnt2	GATA6	22413(Tax:10090)	14465(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Wnt2 is a direct downstream target of GATA6 during early cardiogenesis .
19815336	0	Wnt3	117,121	DVL3	146,150	Wnt3	DVL3	7473	1857	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	MSX1 induces the Wnt pathway antagonist genes DKK1 , DKK2 , DKK3 , and SFRP1 in neuroblastoma cells , but does not block Wnt3 and Wnt5A signalling to DVL3 .
18242177	0	Wnt3A	27,32	R-spondin1	0,10	Wnt3A	R-spondin1	22416(Tax:10090)	192199(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression .
20347274	0	Wnt3a	168,173	EP2	127,130	Wnt3a	EP2	89780	5732	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Identification of transcriptional targets of Wnt/beta-catenin signaling in dermal papilla cells of human scalp hair follicles : EP2 is a novel transcriptional target of Wnt3a .
17335794	0	Wnt3a	0,5	Lef-1	16,21	Wnt3a	Lef-1	22416(Tax:10090)	16842(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis .
26956881	0	Wnt3a	0,5	NeuroD1	54,61	Wnt3a	NeuroD1	22416(Tax:10090)	18012(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|nmod|END_ENTITY	Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/b-catenin signaling in the hypothalamus .
25854560	0	Wnt3a	1,6	bone_morphogenetic_protein_9	21,49	Wnt3a	bone morphogenetic protein 9	22416(Tax:10090)	12165(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	-LSB- Wnt3a combined with bone_morphogenetic_protein_9 induce C3H10T1/2 cells differentiation into cardiomyocyte-like cells in vitro -RSB- .
20521329	0	Wnt3a	0,5	c-Kit	24,29	Wnt3a	c-Kit	22416(Tax:10090)	16590(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|cells cells|amod|END_ENTITY	Wnt3a activates dormant c-Kit -LRB- - -RRB- bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity .
20161747	0	Wnt4	32,36	EAF1	50,54	Wnt4	EAF1	30123(Tax:7955)	415205(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19 .
23645207	0	Wnt4	14,18	Foxc2	0,5	Wnt4	Foxc2	54361	2303	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis .
25270402	0	Wnt4	33,37	Pax8	0,4	Wnt4	Pax8	84426(Tax:10116)	81819(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells .
16019189	0	Wnt5	24,28	RhoA	0,4	Wnt5	RhoA	30105(Tax:7955)	100006041(Tax:7955)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous : use of zebrafish as an in vivo model for GTPase signaling .
25401518	0	Wnt5A	0,5	ABCB1	16,21	Wnt5A	ABCB1	7474	5243	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/b-catenin pathway .
24335906	0	Wnt5a	0,5	CD146	11,16	Wnt5a	CD146	568191(Tax:7955)	338313(Tax:7955)	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension .
18703641	0	Wnt5a	29,34	CaSR	0,4	Wnt5a	CaSR	7474	846	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	CaSR stimulates secretion of Wnt5a from colonic myofibroblasts to stimulate CDX2 and sucrase-isomaltase using Ror2 on intestinal epithelia .
24879894	0	Wnt5a	26,31	Dapper-1	0,8	Wnt5a	Dapper-1	7474	51339	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Dapper-1 is essential for Wnt5a induced cardiomyocyte hypertrophy by regulating the Wnt/PCP pathway .
25240054	0	Wnt5a	18,23	FZD5	39,43	Wnt5a	FZD5	7474	7855	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Monocyte-secreted Wnt5a interacts with FZD5 in microvascular endothelial cells and induces angiogenesis through tissue factor signaling .
24993819	0	Wnt5a	34,39	IL-1b	0,5	Wnt5a	IL-1b	7474	3553	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	IL-1b mediates MCP-1 induction by Wnt5a in gastric_cancer cells .
23709620	0	Wnt5a	110,115	Insulin-like_growth_factor-I	0,28	Wnt5a	Insulin-like growth factor-I	7474	3479	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor-I stimulates differentiation of ATII cells to ATI-like cells through activation of Wnt5a .
24993819	0	Wnt5a	34,39	MCP-1	15,20	Wnt5a	MCP-1	7474	6347	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|induction induction|compound|END_ENTITY	IL-1b mediates MCP-1 induction by Wnt5a in gastric_cancer cells .
27013470	0	Wnt5a	69,74	MiR-154	0,7	Wnt5a	MiR-154	7474	406946	Gene	Gene	Functions|nmod|START_ENTITY Functions|compound|END_ENTITY	MiR-154 Functions as a Tumor Suppressor in Glioblastoma by Targeting Wnt5a .
22888005	0	Wnt5a	0,5	Notch1	15,21	Wnt5a	Notch1	7474	4851	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein .
25601649	0	Wnt5a	33,38	TRIB3	0,5	Wnt5a	TRIB3	22418(Tax:10090)	228775(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	TRIB3 mediates the expression of Wnt5a and activation of nuclear factor-kB in Porphyromonas endodontalis lipopolysaccharide-treated osteoblasts .
19470740	0	Wnt5a	66,71	Toll-like_receptor_3	28,48	Wnt5a	Toll-like receptor 3	7474	7098	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Phenylmethimazole decreases Toll-like_receptor_3 and noncanonical Wnt5a expression in pancreatic_cancer and melanoma together with tumor cell growth and migration .
26093292	0	Wnt5a	63,68	Wnt16	0,5	Wnt5a	Wnt16	22418(Tax:10090)	93735(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a .
26246285	0	Wnt5a	0,5	b-catenin	131,140	Wnt5a	b-catenin	7474	1499	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|effects effects|nmod|END_ENTITY	Wnt5a attenuates the pathogenic effects of the Wnt/b-catenin pathway in human retinal pigment epithelial cells via down-regulating b-catenin and Snail .
26246285	0	Wnt5a	0,5	b-catenin	131,140	Wnt5a	b-catenin	7474	1499	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|effects effects|nmod|END_ENTITY	Wnt5a attenuates the pathogenic effects of the Wnt/b-catenin pathway in human retinal pigment epithelial cells via down-regulating b-catenin and Snail .
23653377	0	Wnt5a	114,119	wingless-type_MMTV_integration_site_family_member_5a	60,112	Wnt5a	wingless-type MMTV integration site family member 5a	7474	7474	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Circulating secreted frizzled-related protein 5 -LRB- Sfrp5 -RRB- and wingless-type_MMTV_integration_site_family_member_5a -LRB- Wnt5a -RRB- levels in patients with type_2_diabetes_mellitus .
26840931	0	Wnt5a-Ror1	18,28	Ror2	29,33	Wnt5a-Ror1	Ror2	22411(Tax:10090)	26564(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	Essential role of Wnt5a-Ror1 / Ror2 signaling in metanephric mesenchyme and ureteric bud formation .
24220306	0	Wnt5b	0,5	Cdc42	105,110	Wnt5b	Cdc42	81029	998	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Wnt5b promotes the cell motility essential for metastasis of oral_squamous_cell_carcinoma through active Cdc42 and RhoA .
22607194	0	Wnt6	25,29	GATA6	0,5	Wnt6	GATA6	7475	2627	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	GATA6 and FOXA2 regulate Wnt6 expression during extraembryonic endoderm formation .
20501643	0	Wnt7A	127,132	PPARgamma	141,150	Wnt7A	PPARgamma	7476	5468	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Sprouty-4 inhibits transformed cell growth , migration and invasion , and epithelial-mesenchymal transition , and is regulated by Wnt7A through PPARgamma in non-small cell lung_cancer .
20530549	0	Wnt7a	50,55	Frizzled-5	0,10	Wnt7a	Frizzled-5	22421(Tax:10090)	14367(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Frizzled-5 , a receptor for the synaptic organizer Wnt7a , regulates activity-mediated synaptogenesis .
18230341	0	Wnt7a	0,5	Fzd5	23,27	Wnt7a	Fzd5	7476	7855	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP .
18567805	0	Wnt7a	50,55	Secreted_frizzled-related_protein_4	0,35	Wnt7a	Secreted frizzled-related protein 4	7476	6424	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Secreted_frizzled-related_protein_4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial_cancer cells .
18997112	0	Wnt8	64,68	Fgf8a	0,5	Wnt8	Fgf8a	397970(Tax:8355)	399183(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Fgf8a induces neural crest indirectly through the activation of Wnt8 in the paraxial mesoderm .
20978132	0	Wnt8	23,27	Kzp	0,3	Wnt8	Kzp	30122(Tax:7955)	798710(Tax:7955)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Kzp controls canonical Wnt8 signaling to modulate dorsoventral patterning during zebrafish gastrulation .
19353303	0	Wnt_10b	0,7	CCN2	22,26	Wnt 10b	CCN2	7480	1490	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Wnt_10b activates the CCN2 promoter in NIH 3T3 fibroblasts through the Smad response element .
18586116	0	Wnt_inhibitor_factor_1	22,44	Wif1	45,49	Wnt inhibitor factor 1	Wif1	24117(Tax:10090)	24117(Tax:10090)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of Wnt_inhibitor_factor_1 -LRB- Wif1 -RRB- during the development in mouse CNS .
18701434	0	Wnt_inhibitory_factor-1	23,46	Adiponectin	0,11	Wnt inhibitory factor-1	Adiponectin	11197	9370	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Adiponectin stimulates Wnt_inhibitory_factor-1 expression through epigenetic regulations involving the transcription factor specificity_protein_1 .
20697356	0	Wnt_inhibitory_factor-1	30,53	Miz-1	57,62	Wnt inhibitory factor-1	Miz-1	11197	7709	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Wnt_inhibitory_factor-1 by Miz-1 / c-Myc .
16501252	0	Wnt_inhibitory_factor-1	16,39	WIF1	41,45	Wnt inhibitory factor-1	WIF1	11197	11197	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inactivation of Wnt_inhibitory_factor-1 -LRB- WIF1 -RRB- expression by epigenetic silencing is a common event in breast_cancer .
20697356	0	Wnt_inhibitory_factor-1	30,53	c-Myc	63,68	Wnt inhibitory factor-1	c-Myc	11197	4609	Gene	Gene	regulation|nmod|START_ENTITY regulation|parataxis|END_ENTITY	Transcriptional regulation of Wnt_inhibitory_factor-1 by Miz-1 / c-Myc .
26482614	0	Wnt_inhibitory_factor_1	128,151	HOTAIR	24,30	Wnt inhibitory factor 1	HOTAIR	11197	100124700	Gene	Gene	expression|nmod|START_ENTITY regulating|dobj|expression affects|advcl|regulating affects|nsubj|END_ENTITY	The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic_ductal_adenocarcinoma by regulating the expression of Wnt_inhibitory_factor_1 .
24632949	0	Wnt_inhibitory_factor_1	17,40	Wif1	42,46	Wnt inhibitory factor 1	Wif1	11197	11197	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Dysregulation of Wnt_inhibitory_factor_1 -LRB- Wif1 -RRB- expression resulted in aberrant Wnt-b-catenin signaling and cell death of the cloaca endoderm , and anorectal_malformations .
23035048	0	Wolfram_syndrome_1	62,80	WFS1	82,86	Wolfram syndrome 1	WFS1	7466	7466	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Vacuolar-type H + - ATPase V1A subunit is a molecular partner of Wolfram_syndrome_1 -LRB- WFS1 -RRB- protein , which regulates its expression and stability .
25274773	0	Wolfram_syndrome_1	70,88	WFS1	90,94	Wolfram syndrome 1	WFS1	7466	7466	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Sarco -LRB- endo -RRB- plasmic reticulum ATPase -LRB- SERCA -RRB- is a molecular partner of Wolfram_syndrome_1 -LRB- WFS1 -RRB- protein , which negatively regulates its expression .
21454619	0	Wolfram_syndrome_protein	31,55	Smurf1	14,20	Wolfram syndrome protein	Smurf1	22393(Tax:10090)	75788(Tax:10090)	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	The E3 ligase Smurf1 regulates Wolfram_syndrome_protein stability at the endoplasmic reticulum .
19664290	0	Wolframin	23,32	Wfs1	34,38	Wolframin	Wfs1	22393(Tax:10090)	22393(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Male mice with deleted Wolframin -LRB- Wfs1 -RRB- gene have reduced fertility .
15366015	0	Worniu	0,6	Snail	10,15	Worniu	Snail	34906(Tax:7227)	34908(Tax:7227)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Worniu , a Snail family zinc-finger protein , is required for brain development in Drosophila .
19250907	0	Wrap53	0,6	p53	18,21	Wrap53	p53	55135	7157	Gene	Gene	required|advmod|START_ENTITY required|nsubj|transcript transcript|compound|END_ENTITY	Wrap53 , a natural p53 antisense transcript required for p53 induction upon DNA damage .
19250907	0	Wrap53	0,6	p53	56,59	Wrap53	p53	55135	7157	Gene	Gene	required|advmod|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	Wrap53 , a natural p53 antisense transcript required for p53 induction upon DNA damage .
19571673	0	Wrap53	0,6	p53	29,32	Wrap53	p53	55135	7157	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Wrap53 , a novel regulator of p53 .
24696455	0	Wrap53	100,106	p53	25,28	Wrap53	p53	55135	7157	Gene	Gene	transcript|appos|START_ENTITY interaction|nmod|transcript regulates|nmod|interaction regulates|dobj|gene gene|compound|END_ENTITY	CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript , Wrap53 .
18086875	0	Wrch1	24,29	Pyk2	81,85	Wrch1	Pyk2	58480	2185	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics .
16514150	0	Wsc1p	59,64	Rho3	4,8	Wsc1p	Rho3	854170(Tax:4932)	854688(Tax:4932)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The Rho3 and Rho4 small GTPases interact functionally with Wsc1p , a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces_cerevisiae .
23562652	0	Wt1	28,31	Coronin_1B	42,52	Wt1	Coronin 1B	22431(Tax:10090)	23789(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The Wilms ' _ tumor suppressor Wt1 regulates Coronin_1B expression in the epicardium .
16571910	0	Wt1	30,33	Sry	48,51	Wt1	Sry	22431(Tax:10090)	21674(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of endogenous Wt1 expression by Sry transgene in the murine embryonic mesonephros-derived M15 cell line .
18403409	0	Wt1	0,3	beta-catenin	25,37	Wt1	beta-catenin	7490	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Wt1 negatively regulates beta-catenin signaling during testis development .
18424770	0	Wt1	28,31	erythropoietin_receptor	63,86	Wt1	erythropoietin receptor	22431(Tax:10090)	13857(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	The Wilms ' _ tumor suppressor Wt1 activates transcription of the erythropoietin_receptor in hematopoietic progenitor cells .
20811903	0	Wt1	22,25	vascular_endothelial_cadherin	72,101	Wt1	vascular endothelial cadherin	22431(Tax:10090)	12562(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|nmod|END_ENTITY	Wilms ' _ tumour protein Wt1 stimulates transcription of the gene encoding vascular_endothelial_cadherin .
19785987	0	Wtip	23,27	Ror2	72,76	Wtip	Ror2	126374	4920	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling .
17909041	0	Wwox	15,19	ErbB4	25,30	Wwox	ErbB4	51741	2066	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of Wwox with ErbB4 in breast_cancer .
22912667	0	Wwp2	17,21	MiR-25	0,6	Wwp2	MiR-25	66894(Tax:10090)	723926(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs .
24365151	0	Wwp2	0,4	SRG3	13,17	Wwp2	SRG3	11060	6599	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Wwp2 targets SRG3 , a scaffold protein of the SWI/SNF-like BAF complex , for ubiquitination and degradation .
25142138	0	X-Linked_Inhibitor_of_Apoptotic_Protein	18,57	XIAP	59,63	X-Linked Inhibitor of Apoptotic Protein	XIAP	11798(Tax:10090)	11798(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of X-Linked_Inhibitor_of_Apoptotic_Protein -LRB- XIAP -RRB- reduces age-related neuronal_degeneration in the mouse cochlea .
17494074	0	X-box-binding_protein_1	0,23	protein_kinase_D	95,111	X-box-binding protein 1	protein kinase D	7494	5587	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	X-box-binding_protein_1 activates lytic Epstein-Barr_virus gene expression in combination with protein_kinase_D .
22038282	0	X-box_binding_protein-1	47,70	XBP1	72,76	X-box binding protein-1	XBP1	7494	7494	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	A quantitative method for detection of spliced X-box_binding_protein-1 -LRB- XBP1 -RRB- mRNA as a measure of endoplasmic reticulum -LRB- ER -RRB- stress .
16327981	0	X-box_binding_protein-1	64,87	interferon_regulatory_factor-1	26,56	X-box binding protein-1	interferon regulatory factor-1	7494	3659	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Expression patterns among interferon_regulatory_factor-1 , human X-box_binding_protein-1 , nuclear factor kappa B , nucleophosmin , estrogen_receptor-alpha and progesterone receptor proteins in breast_cancer tissue microarrays .
18412159	0	X-box_binding_protein_1	112,135	IFN-beta	89,97	X-box binding protein 1	IFN-beta	7494	3456	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box_binding_protein_1 .
17352224	0	X-box_binding_protein_1	24,47	XBP-1	49,54	X-box binding protein 1	XBP-1	7494	7494	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of human X-box_binding_protein_1 -LRB- XBP-1 -RRB- in colorectal_adenomas and adenocarcinomas .
20170659	0	X-box_binding_protein_1	0,23	brain_natriuretic_peptide	34,59	X-box binding protein 1	brain natriuretic peptide	7494	4879	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	X-box_binding_protein_1 regulates brain_natriuretic_peptide through a novel AP1/CRE-like element in cardiomyocytes .
11813207	0	X-box_binding_protein_1	25,48	hXBP-1	50,56	X-box binding protein 1	hXBP-1	7494	7494	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|dep|END_ENTITY	Down-regulation of human X-box_binding_protein_1 -LRB- hXBP-1 -RRB- expression correlates with tumor progression in human prostate_cancers .
25223794	0	X-box_binding_protein_1	0,23	peroxisome_proliferator-activated_receptor_y2	52,97	X-box binding protein 1	peroxisome proliferator-activated receptor y2	7494	5468	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	X-box_binding_protein_1 is a novel key regulator of peroxisome_proliferator-activated_receptor_y2 .
26676658	0	X-chromosome-linked_inhibitor_of_apoptosis	95,137	miR-215	0,7	X-chromosome-linked inhibitor of apoptosis	miR-215	331	406997	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	miR-215 functions as a tumor suppressor in epithelial_ovarian_cancer through regulation of the X-chromosome-linked_inhibitor_of_apoptosis .
10678660	0	X-linked_agammaglobulinemia	17,44	XLA	46,49	X-linked agammaglobulinemia	XLA	695	695	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Twin carriers of X-linked_agammaglobulinemia -LRB- XLA -RRB- due to germline mutation in the Btk gene .
26659383	0	X-linked_ectodermal_dysplasia_receptor	0,38	XEDAR	40,45	X-linked ectodermal dysplasia receptor	XEDAR	60401	60401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	X-linked_ectodermal_dysplasia_receptor -LRB- XEDAR -RRB- gene silencing prevents caspase-3-mediated apoptosis in Sj gren 's _ syndrome .
3494095	0	X-linked_immunodeficiency	58,83	xid	85,88	X-linked immunodeficiency	xid	12229(Tax:10090)	12229(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Development of B lymphocytes in mice heterozygous for the X-linked_immunodeficiency -LRB- xid -RRB- mutation .
9394795	0	X-linked_immunodeficiency	34,59	xid	61,64	X-linked immunodeficiency	xid	12229(Tax:10090)	12229(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A re-evaluation of the effects of X-linked_immunodeficiency -LRB- xid -RRB- mutation on B cell differentiation and function in the mouse .
10962579	0	X-linked_inhibitor_of_apoptosis	30,61	XIAP	63,67	X-linked inhibitor of apoptosis	XIAP	331	331	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Translational upregulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- increases resistance to radiation induced cell death .
15207275	0	X-linked_inhibitor_of_apoptosis	0,31	XIAP	33,37	X-linked inhibitor of apoptosis	XIAP	11798(Tax:10090)	11798(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- protein protects against caspase activation and tissue loss after neonatal_hypoxia-ischemia .
18687476	0	X-linked_inhibitor_of_apoptosis	10,41	XIAP	51,55	X-linked inhibitor of apoptosis	XIAP	11798(Tax:10090)	11798(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Increased X-linked_inhibitor_of_apoptosis protein -LRB- XIAP -RRB- expression exacerbates experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
21709246	0	X-linked_inhibitor_of_apoptosis	22,53	XIAP	55,59	X-linked inhibitor of apoptosis	XIAP	331	331	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	miR-23a regulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- contributes to sex differences in the response to cerebral_ischemia .
24446252	0	X-linked_inhibitor_of_apoptosis	30,61	XIAP	63,67	X-linked inhibitor of apoptosis	XIAP	331	331	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Tissue microarray analysis of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- expression in breast_cancer patients .
21709246	0	X-linked_inhibitor_of_apoptosis	22,53	miR-23a	0,7	X-linked inhibitor of apoptosis	miR-23a	331	407010	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	miR-23a regulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- contributes to sex differences in the response to cerebral_ischemia .
19473982	0	X-linked_inhibitor_of_apoptosis_protein	0,39	PTEN	57,61	X-linked inhibitor of apoptosis protein	PTEN	11798(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- regulates PTEN ubiquitination , content , and compartmentalization .
17050666	0	X-linked_inhibitor_of_apoptosis_protein	121,160	TRAIL	84,89	X-linked inhibitor of apoptosis protein	TRAIL	331	8743	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Constitutively activated nuclear_factor-kappaB , but not induced NF-kappaB , leads to TRAIL resistance by up-regulation of X-linked_inhibitor_of_apoptosis_protein in human cancer cells .
17308080	0	X-linked_inhibitor_of_apoptosis_protein	102,141	TRAIL	19,24	X-linked inhibitor of apoptosis protein	TRAIL	331	8743	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression lines|nmod|inhibition reverses|nmod|lines reverses|dobj|resistance resistance|amod|END_ENTITY	Gefitinib reverses TRAIL resistance in human bladder_cancer cell lines via inhibition of AKT-mediated X-linked_inhibitor_of_apoptosis_protein expression .
19654940	0	X-linked_inhibitor_of_apoptosis_protein	18,57	XIAP	59,63	X-linked inhibitor of apoptosis protein	XIAP	331	331	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- is an independent unfavorable prognostic factor in childhood de novo acute_myeloid_leukemia .
23720779	0	X-linked_inhibitor_of_apoptosis_protein	0,39	XIAP	41,45	X-linked inhibitor of apoptosis protein	XIAP	331	331	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- regulation of cyclin_D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis .
12920343	0	X-linked_juvenile_retinoschisis	29,60	XLRS1	62,67	X-linked juvenile retinoschisis	XLRS1	6247	6247	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Three novel mutations in the X-linked_juvenile_retinoschisis -LRB- XLRS1 -RRB- gene in 6 Japanese patients , 1 of whom had Turner 's _ syndrome .
1972651	0	X-linked_lymphoproliferative_disease	43,79	XLP	81,84	X-linked lymphoproliferative disease	XLP	4068	4068	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Partial Xq25 deletion in a family with the X-linked_lymphoproliferative_disease -LRB- XLP -RRB- X-linked_lymphoproliferative_disease -LRB- XLP -RRB- results in exquisite vulnerability to EBV_infection : fatal infectious_mononucleosis -LRB- IM -RRB- , acquired_hypogammaglobulinemia and/or malignant_lymphoma occur invariably following infection with the virus .
10636421	0	X-linked_retinoschisis	0,22	XLRS1	51,56	X-linked retinoschisis	XLRS1	6247	6247	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	X-linked_retinoschisis with point mutations in the XLRS1 gene .
18834580	0	X-linked_retinoschisis	54,76	retinoschisin	116,129	X-linked retinoschisis	retinoschisin	6247	6247	Gene	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of response to treatment with dorzolamide in X-linked_retinoschisis to the mechanism of functional loss in retinoschisin .
16880568	0	X-ray_analysis_of_excisionase	45,74	Xis	76,79	X-ray analysis of excisionase	Xis	2703504(Tax:10710)	2703504(Tax:10710)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Crystallization , dehydration and preliminary X-ray_analysis_of_excisionase -LRB- Xis -RRB- proteins cooperatively bound to DNA .
27026405	0	X-ray_repair_cross-complement_group_1	42,79	XRCC1	81,86	X-ray repair cross-complement group 1	XRCC1	7515	7515	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
27026405	0	X-ray_repair_cross-complement_group_1	42,79	p38	23,26	X-ray repair cross-complement group 1	p38	7515	1432	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
10574372	0	X11L2	34,39	APBA3	46,51	X11L2	APBA3	9546	9546	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the human X11L2 gene -LRB- APBA3 -RRB- , a third member of the X11 protein family interacting with Alzheimer 's beta-amyloid_precursor_protein .
11083918	0	X11_alpha	0,9	presenilin-1	37,49	X11 alpha	presenilin-1	320	5663	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	X11_alpha and x11_beta interact with presenilin-1 via their PDZ domains .
18575606	0	X11_and_ubiquilin	8,25	amyloid_precursor_protein	55,80	X11 and ubiquilin	amyloid precursor protein	252671;32977	31002(Tax:7227)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of X11_and_ubiquilin as in vivo regulators of the amyloid_precursor_protein in Drosophila .
11058119	0	XAB1	27,31	XPA	66,69	XAB1	XPA	11321	7507	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA .
16303760	0	XAF1	20,24	HSF1	0,4	XAF1	HSF1	54739	3297	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	HSF1 down-regulates XAF1 through transcriptional regulation .
21143993	0	XAF1	0,4	XAF1	58,62	XAF1	XAF1	54739	54739	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate_cancer cells .
21143993	0	XAF1	58,62	XAF1	0,4	XAF1	XAF1	54739	54739	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate_cancer cells .
11087668	0	XAF1	61,65	XIAP-associated_factor_1	35,59	XAF1	XIAP-associated factor 1	54739	54739	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression and genetic analysis of XIAP-associated_factor_1 -LRB- XAF1 -RRB- in cancer cell lines .
19664236	0	XAF1	63,67	XIAP_associated_factor-1	37,61	XAF1	XIAP associated factor-1	54739	54739	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of the pro-apoptotic XIAP_associated_factor-1 -LRB- XAF1 -RRB- during progression of clear-cell_renal_cancer .
21143993	0	XAF1	0,4	somatostatin	42,54	XAF1	somatostatin	54739	6750	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate_cancer cells .
21143993	0	XAF1	58,62	somatostatin	42,54	XAF1	somatostatin	54739	6750	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate_cancer cells .
26009453	0	XAF1	38,42	somatostatin	22,34	XAF1	somatostatin	54739	6750	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of somatostatin on XAF1 in prostate_cancer .
9790916	0	XAG-2	67,72	hAG-2	0,5	XAG-2	hAG-2	379354(Tax:8355)	10551	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	hAG-2 , the human homologue of the Xenopus_laevis cement gland gene XAG-2 , is coexpressed with estrogen receptor in breast_cancer cell lines .
22109656	0	XAGE-1b	63,70	CD4	26,29	XAGE-1b	CD4	653220	920	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Spontaneous antibody , and CD4 and CD8 T-cell responses against XAGE-1b -LRB- GAGED2a -RRB- in non-small cell lung_cancer patients .
12752499	0	XALK4	54,59	activin_type_IB_receptor	28,52	XALK4	activin type IB receptor	399454(Tax:8355)	399454(Tax:8355)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunocytochemical study of activin_type_IB_receptor -LRB- XALK4 -RRB- in Xenopus oocytes .
19375531	0	XAP2	0,4	glucocorticoid_receptor	14,37	XAP2	glucocorticoid receptor	9049	2908	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	XAP2 inhibits glucocorticoid_receptor activity in mammalian cells .
21163961	0	XAP5_CIRCADIAN_TIMEKEEPER	0,25	ethylene	36,44	XAP5 CIRCADIAN TIMEKEEPER	ethylene	816650(Tax:3702)	821625(Tax:3702)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	XAP5_CIRCADIAN_TIMEKEEPER regulates ethylene responses in aerial tissues of Arabidopsis .
15351732	0	XBP-1	0,5	ERalpha	16,23	XBP-1	ERalpha	7494	2099	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|activity activity|compound|END_ENTITY	XBP-1 increases ERalpha transcriptional activity through regulation of large-scale chromatin unfolding .
17560942	0	XBP-1	0,5	IGF1	80,84	XBP-1	IGF1	140614(Tax:7955)	114433(Tax:7955)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	XBP-1 , a key regulator of unfolded protein response , activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line .
24812669	0	XBP-1	41,46	IRE-1	35,40	XBP-1	IRE-1	22433(Tax:10090)	26918(Tax:10090)	Gene	Gene	reduces|nsubj|START_ENTITY Inhibition|parataxis|reduces Inhibition|nmod|END_ENTITY	Inhibition of ER stress-associated IRE-1 / XBP-1 pathway reduces leukemic cell survival .
25469499	0	XBP-1	6,11	IRE-1	0,5	XBP-1	IRE-1	175541(Tax:6239)	174305(Tax:6239)	Gene	Gene	pathway|compound|START_ENTITY required|nsubjpass|pathway END_ENTITY|appos|required	IRE-1 / XBP-1 pathway of the unfolded protein response is required for properly localizing neuronal UNC-6 / Netrin for axon guidance in C. __ elegans .
27055592	0	XBP-1	65,70	IRE-1	59,64	XBP-1	IRE-1	175541(Tax:6239)	174305(Tax:6239)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	PEK-1 is crucial for hormesis induced by inhibition of the IRE-1 / XBP-1 pathway in the Caenorhabditis_elegans mev-1 mutant .
21423203	0	XBP-1	51,56	Mcl-1	31,36	XBP-1	Mcl-1	7494	4170	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress .
17709512	0	XBP-1	67,72	OCA-B	40,45	XBP-1	OCA-B	7494	5450	Gene	Gene	targets|nmod|START_ENTITY END_ENTITY|nmod|targets	Identification of ERdj3 and OBF-1 / BOB-1 / OCA-B as direct targets of XBP-1 during plasma cell differentiation .
17352224	0	XBP-1	49,54	X-box_binding_protein_1	24,47	XBP-1	X-box binding protein 1	7494	7494	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of human X-box_binding_protein_1 -LRB- XBP-1 -RRB- in colorectal_adenomas and adenocarcinomas .
12954762	0	XBP-1	60,65	estrogen_receptor_alpha	33,56	XBP-1	estrogen receptor alpha	7494	2099	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Ligand-independent activation of estrogen_receptor_alpha by XBP-1 .
23337584	0	XBP1	10,14	FoxO1	42,47	XBP1	FoxO1	7494	2308	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Unspliced XBP1 controls autophagy through FoxO1 .
25633224	0	XBP1	76,80	GPR43	36,41	XBP1	GPR43	7494	2867	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The short-chain fatty_acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes .
26347999	0	XBP1	77,81	PNPLA3	0,6	XBP1	PNPLA3	22433(Tax:10090)	116939(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	PNPLA3 is involved in hepatic fatty_acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice .
26347999	0	XBP1	77,81	PNPLA3	0,6	XBP1	PNPLA3	22433(Tax:10090)	116939(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	PNPLA3 is involved in hepatic fatty_acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice .
22038282	0	XBP1	72,76	X-box_binding_protein-1	47,70	XBP1	X-box binding protein-1	7494	7494	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	A quantitative method for detection of spliced X-box_binding_protein-1 -LRB- XBP1 -RRB- mRNA as a measure of endoplasmic reticulum -LRB- ER -RRB- stress .
17890727	0	XBP1	61,65	brain-derived_neurotrophic_factor	12,45	XBP1	brain-derived neurotrophic factor	7494	627	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced XBP1 splicing during brain development .
25280941	0	XBP1	0,4	snail	13,18	XBP1	snail	7494	6615	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	XBP1 induces snail expression to promote epithelial - to-mesenchymal transition and invasion of breast_cancer cells .
10698686	0	XCE	62,65	ECEL1	55,60	XCE	ECEL1	9427	9427	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Organization and chromosomal localization of the human ECEL1 -LRB- XCE -RRB- gene encoding a zinc metallopeptidase involved in the nervous control of respiration .
12972573	0	XChk1	41,46	XRad17	0,6	XChk1	XRad17	398191(Tax:8355)	398572(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus .
7956361	0	XDH	43,46	xanthine_dehydrogenase	19,41	XDH	xanthine dehydrogenase	7498	7498	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	The human gene for xanthine_dehydrogenase -LRB- XDH -RRB- is localized on chromosome band 2q22 .
8661045	0	XDH	81,84	xanthine_dehydrogenase	52,74	XDH	xanthine dehydrogenase	7498	7498	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular cloning and characterization of the human xanthine_dehydrogenase gene -LRB- XDH -RRB- .
20501644	0	XEDAR	20,25	EDA-A2	13,19	XEDAR	EDA-A2	60401	1896	Gene	Gene	START_ENTITY|dep|Crosstalk Crosstalk|nmod|END_ENTITY	Crosstalk of EDA-A2 / XEDAR in the p53 signaling pathway .
26659383	0	XEDAR	40,45	X-linked_ectodermal_dysplasia_receptor	0,38	XEDAR	X-linked ectodermal dysplasia receptor	60401	60401	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	X-linked_ectodermal_dysplasia_receptor -LRB- XEDAR -RRB- gene silencing prevents caspase-3-mediated apoptosis in Sj gren 's _ syndrome .
15713843	0	XErp1	40,45	Plx1	25,29	XErp1	Plx1	100101275(Tax:8355)	380481(Tax:8355)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Xenopus polo-like kinase Plx1 regulates XErp1 , a novel inhibitor of APC/C activity .
8253274	0	XFKH2	0,5	HNF-3_alpha	17,28	XFKH2	HNF-3 alpha	100125667(Tax:8355)	100125667(Tax:8355)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	XFKH2 , a Xenopus HNF-3_alpha homologue , exhibits both activin-inducible and autonomous phases of expression in early embryos .
12050132	0	XFast-1	89,96	Xenopus_Smad-interacting_forkhead_transcription_factor	8,62	XFast-1	Xenopus Smad-interacting forkhead transcription factor	398070(Tax:8355)	100337554(Tax:8355)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	A novel Xenopus_Smad-interacting_forkhead_transcription_factor -LRB- XFast-3 -RRB- cooperates with XFast-1 in regulating gastrulation movements .
7533029	0	XG_blood_group	12,26	PBDX	0,4	XG blood group	PBDX	7499	7499	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	PBDX is the XG_blood_group gene .
19726736	0	XIAP	104,108	AKT	0,3	XIAP	AKT	331	207	Gene	Gene	expression|compound|START_ENTITY regulating|dobj|expression controls|advcl|regulating controls|nsubj|END_ENTITY	AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression .
20632385	0	XIAP	27,31	AKT	84,87	XIAP	AKT	331	207	Gene	Gene	expression|compound|START_ENTITY significance|nmod|expression significance|nmod|signalling signalling|compound|END_ENTITY	Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling .
11280739	0	XIAP	0,4	Akt	15,18	XIAP	Akt	331	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian_epithelial_cancer cells .
14645242	0	XIAP	82,86	Akt	0,3	XIAP	Akt	331	207	Gene	Gene	X-linked_inhibitor_of_apoptosis_protein|appos|START_ENTITY phosphorylation|nmod|X-linked_inhibitor_of_apoptosis_protein END_ENTITY|dobj|phosphorylation	Akt phosphorylation and stabilization of X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- .
19649722	0	XIAP	45,49	Akt	19,22	XIAP	Akt	331	207	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|nsubj|course course|nmod|END_ENTITY	The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line .
23613836	0	XIAP	60,64	Akt	74,77	XIAP	Akt	331	207	Gene	Gene	thymoquinone|nmod|START_ENTITY effects|nmod|thymoquinone mediated|nsubj|effects mediated|dobj|regulation regulation|compound|END_ENTITY	Targeted apoptotic effects of thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast_cancer .
17698078	0	XIAP	40,44	BIR1	25,29	XIAP	BIR1	331	3763	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|domain domain|compound|END_ENTITY	Crystal structure of the BIR1 domain of XIAP in two crystal forms .
20856198	0	XIAP	18,22	Caspase-3	0,9	XIAP	Caspase-3	331	836	Gene	Gene	START_ENTITY|nsubj|cleaves cleaves|amod|END_ENTITY	Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis .
26840743	0	XIAP	47,51	EPAC2	86,91	XIAP	EPAC2	63879(Tax:10116)	252857(Tax:10116)	Gene	Gene	START_ENTITY|dep|Role Role|nmod|END_ENTITY	Urocortin-1 Mediated Cardioprotection Involves XIAP and CD40-Ligand Recovery : Role of EPAC2 and ERK1/2 .
26404623	0	XIAP	14,18	FOXM1	0,5	XIAP	FOXM1	331	2305	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	FOXM1 targets XIAP and Survivin to modulate breast_cancer survival and chemoresistance .
19825980	0	XIAP	17,21	HuR	59,62	XIAP	HuR	331	1994	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines .
22733138	0	XIAP	22,26	MicroRNA-24	0,11	XIAP	MicroRNA-24	331	407012	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-24 regulates XIAP to reduce the apoptosis threshold in cancer cells .
25939870	0	XIAP	41,45	RIP1	17,21	XIAP	RIP1	331	8737	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly .
19667203	0	XIAP	0,4	RIP2	49,53	XIAP	RIP2	331	8767	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	XIAP mediates NOD signaling via interaction with RIP2 .
22815893	0	XIAP	104,108	RIP2	114,118	XIAP	RIP2	331	8767	Gene	Gene	interaction|nmod|START_ENTITY disturbing|dobj|interaction disturbing|nmod|END_ENTITY	The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-kB activation by disturbing the interaction of XIAP with RIP2 .
11717313	1	XIAP	169,173	Smac	153,157	XIAP	Smac	331	56616	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Hid binds Op-IAP in a manner similar to Smac binding of XIAP .
12121969	0	XIAP	58,62	Smac	35,39	XIAP	Smac	331	56616	Gene	Gene	Smac|compound|START_ENTITY degradation|dep|Smac degradation|nmod|END_ENTITY	Proteasome-mediated degradation of Smac during apoptosis : XIAP promotes Smac ubiquitination in vitro .
14512414	0	XIAP	112,116	Smac	149,153	XIAP	Smac	331	56616	Gene	Gene	protein|appos|START_ENTITY inhibitor|nmod|protein relief|nmod|inhibitor Requirement|nmod|relief Requirement|dep|inhibition inhibition|nmod|END_ENTITY	Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein -LRB- XIAP -RRB- - mediated caspase inhibition by Smac .
17291493	0	XIAP	8,12	Smac	118,122	XIAP	Smac	331	56616	Gene	Gene	Role|nmod|START_ENTITY Role|dep|molecule molecule|acl:relcl|mimic mimic|nsubj|END_ENTITY	Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small_cell_lung_cancer cells : a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation .
17686459	0	XIAP	64,68	Smac	19,23	XIAP	Smac	331	56616	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of Smac by JNK3 attenuates its interaction with XIAP .
17999504	0	XIAP	163,167	Smac	90,94	XIAP	Smac	331	56616	Gene	Gene	BIR2|nmod|START_ENTITY targets|dobj|BIR2 mimetic|acl:relcl|targets mimetic|amod|END_ENTITY	Design , synthesis , and characterization of a potent , nonpeptide , cell-permeable , bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP .
18954041	0	XIAP	184,188	Smac	108,112	XIAP	Smac	331	56616	Gene	Gene	X-linked_inhibitor_of_apoptosis_protein|appos|START_ENTITY inhibitors|nmod|X-linked_inhibitor_of_apoptosis_protein mimetics|nmod|inhibitors mimetics|amod|END_ENTITY	Structure-based design , synthesis , evaluation , and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- .
21354220	0	XIAP	67,71	Smac	16,20	XIAP	Smac	331	56616	Gene	Gene	permeabilization|compound|START_ENTITY crucial|nmod|permeabilization crucial|nsubj|Dimerization Dimerization|nmod|END_ENTITY	Dimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilization .
21364655	0	XIAP	0,4	Smac	13,17	XIAP	Smac	331	56616	Gene	Gene	impairs|nsubj|START_ENTITY impairs|dobj|release release|amod|END_ENTITY	XIAP impairs Smac release from the mitochondria during apoptosis .
21680182	0	XIAP	120,124	Smac	47,51	XIAP	Smac	331	56616	Gene	Gene	mimetics|ccomp|START_ENTITY mimetics|nsubj|Design Design|nmod|END_ENTITY	Design , synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP .
22148838	0	XIAP	81,85	Smac	9,13	XIAP	Smac	331	56616	Gene	Gene	antagonists|nmod|START_ENTITY core|nmod|antagonists mimetics|nmod|core mimetics|nsubj|END_ENTITY	Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents .
22325366	0	XIAP	106,110	Smac	4,8	XIAP	Smac	331	56616	Gene	Gene	inhibiting|dobj|START_ENTITY associated|advcl|inhibiting apoptosis|acl|associated induces|dobj|apoptosis induces|nsubj|HCL HCL|compound|END_ENTITY	The Smac mimetic RMT5265 .2 HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome_C and Smac .
22407164	0	XIAP	89,93	Smac	33,37	XIAP	Smac	331	56616	Gene	Gene	protein|compound|START_ENTITY BIR2|nmod|protein targeting|dobj|BIR2 mimics|xcomp|targeting mimics|nsubj|study study|nmod|END_ENTITY	A NMR and computational study of Smac mimics targeting both the BIR2 and BIR3 domains in XIAP protein .
24521431	0	XIAP	111,115	Smac	94,98	XIAP	Smac	331	56616	Gene	Gene	BIR3|compound|START_ENTITY mimetics|nmod|BIR3 mimetics|amod|END_ENTITY	Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells .
24882010	0	XIAP	0,4	TNF	15,18	XIAP	TNF	331	7124	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|END_ENTITY	XIAP restricts TNF - and RIP3-dependent cell death and inflammasome activation .
15126334	0	XIAP	41,45	TRAIL	135,140	XIAP	TRAIL	331	8743	Gene	Gene	inhibitor|appos|START_ENTITY modulator|nsubj|inhibitor modulator|nmod|tumor_necrosis_factor-related_apoptosis-inducing_ligand tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	X-linked inhibitor of apoptosis protein -LRB- XIAP -RRB- is a nonredundant modulator of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - mediated apoptosis in human cancer cells .
16953886	0	XIAP	28,32	TRAIL	110,115	XIAP	TRAIL	442989(Tax:9615)	100174780(Tax:9615)	Gene	Gene	down-regulation|nmod|START_ENTITY enhances|nsubj|down-regulation enhances|nmod|END_ENTITY	Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin .
18829553	0	XIAP	10,14	TRAIL	53,58	XIAP	TRAIL	11798(Tax:10090)	22035(Tax:10090)	Gene	Gene	bypasses|nsubj|START_ENTITY bypasses|nmod|END_ENTITY	Targeting XIAP bypasses Bcl-2-mediated resistance to TRAIL and cooperates with TRAIL to suppress pancreatic_cancer growth in vitro and in vivo .
19034449	0	XIAP	7,11	TRAIL	80,85	XIAP	TRAIL	331	8743	Gene	Gene	clones|compound|START_ENTITY sensitive|nsubj|clones sensitive|nmod|END_ENTITY	Stable XIAP knockdown clones of HCT116 colon_cancer cells are more sensitive to TRAIL , taxanes and irradiation in vitro .
19036706	0	XIAP	15,19	TRAIL	46,51	XIAP	TRAIL	11798(Tax:10090)	22035(Tax:10090)	Gene	Gene	START_ENTITY|ccomp|cooperate cooperate|nmod|END_ENTITY	Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute_leukemia cells and overcome Bcl-2-mediated resistance .
19179889	0	XIAP	53,57	TRAIL	142,147	XIAP	TRAIL	331	8743	Gene	Gene	START_ENTITY|nmod|lines lines|acl:relcl|responsible responsible|nmod|apoptosis apoptosis|nmod|END_ENTITY	A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL .
22104728	0	XIAP	33,37	TRAIL	84,89	XIAP	TRAIL	331	8743	Gene	Gene	targeting|nmod|START_ENTITY combined|advcl|targeting IFN-y|acl|combined leads|nsubj|IFN-y leads|nmod|apoptosis-sensitisation apoptosis-sensitisation|nmod|cells cells|compound|END_ENTITY	IFN-y combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic_carcinoma cells .
22508521	0	XIAP	0,4	TRAIL	67,72	XIAP	TRAIL	331	8743	Gene	Gene	inhibition|compound|START_ENTITY enhances|nsubj|inhibition enhances|dobj|sensitivity sensitivity|compound|END_ENTITY	XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory_breast_cancer cells .
22799350	0	XIAP	53,57	TRAIL	80,85	XIAP	TRAIL	331	8743	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of malignant_melanoma by downregulation of XIAP and overexpression of TRAIL with a conditionally replicating oncolytic adenovirus .
25358405	0	XIAP	65,69	TRAIL	51,56	XIAP	TRAIL	331	8743	Gene	Gene	Inhibition|compound|START_ENTITY END_ENTITY|nmod|Inhibition	Embelin Sensitizes Acute Myeloid_Leukemia Cells to TRAIL through XIAP Inhibition and NF-kB Inactivation .
25142138	0	XIAP	59,63	X-Linked_Inhibitor_of_Apoptotic_Protein	18,57	XIAP	X-Linked Inhibitor of Apoptotic Protein	11798(Tax:10090)	11798(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of X-Linked_Inhibitor_of_Apoptotic_Protein -LRB- XIAP -RRB- reduces age-related neuronal_degeneration in the mouse cochlea .
10962579	0	XIAP	63,67	X-linked_inhibitor_of_apoptosis	30,61	XIAP	X-linked inhibitor of apoptosis	331	331	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Translational upregulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- increases resistance to radiation induced cell death .
15207275	0	XIAP	33,37	X-linked_inhibitor_of_apoptosis	0,31	XIAP	X-linked inhibitor of apoptosis	11798(Tax:10090)	11798(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- protein protects against caspase activation and tissue loss after neonatal_hypoxia-ischemia .
18687476	0	XIAP	51,55	X-linked_inhibitor_of_apoptosis	10,41	XIAP	X-linked inhibitor of apoptosis	11798(Tax:10090)	11798(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Increased X-linked_inhibitor_of_apoptosis protein -LRB- XIAP -RRB- expression exacerbates experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
21709246	0	XIAP	55,59	X-linked_inhibitor_of_apoptosis	22,53	XIAP	X-linked inhibitor of apoptosis	331	331	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	miR-23a regulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- contributes to sex differences in the response to cerebral_ischemia .
24446252	0	XIAP	63,67	X-linked_inhibitor_of_apoptosis	30,61	XIAP	X-linked inhibitor of apoptosis	331	331	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Tissue microarray analysis of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- expression in breast_cancer patients .
19654940	0	XIAP	59,63	X-linked_inhibitor_of_apoptosis_protein	18,57	XIAP	X-linked inhibitor of apoptosis protein	331	331	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- is an independent unfavorable prognostic factor in childhood de novo acute_myeloid_leukemia .
23720779	0	XIAP	41,45	X-linked_inhibitor_of_apoptosis_protein	0,39	XIAP	X-linked inhibitor of apoptosis protein	331	331	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- regulation of cyclin_D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis .
16432762	0	XIAP	98,102	Xaf1	0,4	XIAP	Xaf1	331	54739	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Xaf1 can cooperate with TNFalpha in the induction of apoptosis , independently of interaction with XIAP .
11257232	0	XIAP	52,56	caspase-3	39,48	XIAP	caspase-3	331	836	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|inhibition inhibition|nmod|END_ENTITY	Structural basis for the inhibition of caspase-3 by XIAP .
12181739	0	XIAP	0,4	caspase-3	19,28	XIAP	caspase-3	331	836	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95 - and Bax-induced apoptosis .
12826269	0	XIAP	114,118	caspase-3	81,90	XIAP	caspase-3	331	836	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Immunosuppressant PG490 -LRB- triptolide -RRB- induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells .
17291493	0	XIAP	8,12	caspase-3	188,197	XIAP	caspase-3	331	836	Gene	Gene	Role|nmod|START_ENTITY Role|dep|molecule molecule|acl:relcl|mimic mimic|advcl|enhancing enhancing|dobj|activation activation|amod|END_ENTITY	Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small_cell_lung_cancer cells : a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation .
17724022	0	XIAP	72,76	caspase-3	48,57	XIAP	caspase-3	331	836	Gene	Gene	relieves|nmod|START_ENTITY relieves|dobj|inhibition inhibition|amod|END_ENTITY	A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP .
22732633	0	XIAP	129,133	caspase-3	84,93	XIAP	caspase-3	11798(Tax:10090)	12367(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|activation activation|amod|END_ENTITY	Anti-cancer effects of thymoquinone in mouse neuroblastoma -LRB- Neuro-2a -RRB- cells through caspase-3 activation with down-regulation of XIAP .
23156805	0	XIAP	42,46	caspase-3	48,57	XIAP	caspase-3	331	836	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	-LSB- The expression and significance of smac , XIAP , caspase-3 in nonnasal_inverted_papilloma -RSB- .
17437405	0	XIAP	21,25	caspase_9	91,100	XIAP	caspase 9	331	842	Gene	Gene	START_ENTITY|dep|inhibition inhibition|nmod|END_ENTITY	Caspase_3 attenuates XIAP -LRB- X-linked inhibitor of apoptosis protein -RRB- - mediated inhibition of caspase_9 .
17534699	0	XIAP	68,72	hepatocyte_growth_factor	10,34	XIAP	hepatocyte growth factor	331	3082	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of hepatocyte_growth_factor -LRB- HGF -RRB- on the level of Survivin _ XIAP expression in several human cancer cell lines , after treating with DNA damaging agent .
21709246	0	XIAP	55,59	miR-23a	0,7	XIAP	miR-23a	331	407010	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	miR-23a regulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- contributes to sex differences in the response to cerebral_ischemia .
24821285	0	XIAP	28,32	microRNA-200c	0,13	XIAP	microRNA-200c	331	406985	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	microRNA-200c downregulates XIAP expression to suppress proliferation and promote apoptosis of triple-negative breast_cancer cells .
20082449	0	XIAP-Associated_factor_1	17,41	tumor_necrosis_factor-related_apoptosis-inducing_ligand	65,120	XIAP-Associated factor 1	tumor necrosis factor-related apoptosis-inducing ligand	327959(Tax:10090)	22035(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|END_ENTITY	Tumor suppressor XIAP-Associated_factor_1 -LRB- XAF1 -RRB- cooperates with tumor_necrosis_factor-related_apoptosis-inducing_ligand to suppress colon_cancer growth and trigger tumor regression .
11087668	0	XIAP-associated_factor_1	35,59	XAF1	61,65	XIAP-associated factor 1	XAF1	54739	54739	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression and genetic analysis of XIAP-associated_factor_1 -LRB- XAF1 -RRB- in cancer cell lines .
21678496	0	XIAP-associated_factor_1	0,24	p53	51,54	XIAP-associated factor 1	p53	54739	7157	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	XIAP-associated_factor_1 -LRB- XAF1 -RRB- , a novel target of p53 , enhances p53-mediated apoptosis via post-translational modification .
19664236	0	XIAP_associated_factor-1	37,61	XAF1	63,67	XIAP associated factor-1	XAF1	54739	54739	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of the pro-apoptotic XIAP_associated_factor-1 -LRB- XAF1 -RRB- during progression of clear-cell_renal_cancer .
2632231	0	XIF3	0,4	peripherin	16,26	XIF3	peripherin	380221(Tax:8355)	380221(Tax:8355)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	XIF3 , a Xenopus peripherin gene , requires an inductive signal for enhanced expression in anterior neural tissue .
25582710	0	XIP	62,65	NCX1	76,80	XIP	NCX1	10542	6546	Gene	Gene	Domain|compound|START_ENTITY Domain|nmod|END_ENTITY	A New Cell-penetrating Peptide That Blocks the Autoinhibitory XIP Domain of NCX1 and Enhances Antiporter Activity .
16769694	0	XIST	0,4	DNMT1	34,39	XIST	DNMT1	7503	1786	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	XIST repression in the absence of DNMT1 and DNMT3B .
10678660	0	XLA	46,49	X-linked_agammaglobulinemia	17,44	XLA	X-linked agammaglobulinemia	695	695	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Twin carriers of X-linked_agammaglobulinemia -LRB- XLA -RRB- due to germline mutation in the Btk gene .
1972651	0	XLP	81,84	X-linked_lymphoproliferative_disease	43,79	XLP	X-linked lymphoproliferative disease	4068	4068	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Partial Xq25 deletion in a family with the X-linked_lymphoproliferative_disease -LRB- XLP -RRB- X-linked_lymphoproliferative_disease -LRB- XLP -RRB- results in exquisite vulnerability to EBV_infection : fatal infectious_mononucleosis -LRB- IM -RRB- , acquired_hypogammaglobulinemia and/or malignant_lymphoma occur invariably following infection with the virus .
12920343	0	XLRS1	62,67	X-linked_juvenile_retinoschisis	29,60	XLRS1	X-linked juvenile retinoschisis	6247	6247	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Three novel mutations in the X-linked_juvenile_retinoschisis -LRB- XLRS1 -RRB- gene in 6 Japanese patients , 1 of whom had Turner 's _ syndrome .
10636421	0	XLRS1	51,56	X-linked_retinoschisis	0,22	XLRS1	X-linked retinoschisis	6247	6247	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	X-linked_retinoschisis with point mutations in the XLRS1 gene .
15775959	0	XMAP215	19,26	Mini_spindles	0,13	XMAP215	Mini spindles	41952(Tax:7227)	41952(Tax:7227)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Mini_spindles , the XMAP215 homologue , suppresses pausing of interphase microtubules in Drosophila .
8816774	0	XMCM3	64,69	XMCM7	0,5	XMCM3	XMCM7	397821(Tax:8355)	397852(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	XMCM7 , a novel member of the Xenopus_MCM family , interacts with XMCM3 and colocalizes with it throughout replication .
8816774	0	XMCM7	0,5	XMCM3	64,69	XMCM7	XMCM3	397852(Tax:8355)	397821(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	XMCM7 , a novel member of the Xenopus_MCM family , interacts with XMCM3 and colocalizes with it throughout replication .
9852961	0	XNLRR-1	21,28	neuronal_leucine-rich_repeat_protein	57,93	XNLRR-1	neuronal leucine-rich repeat protein	379684(Tax:8355)	16979(Tax:10090)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Molecular cloning of XNLRR-1 , a Xenopus homolog of mouse neuronal_leucine-rich_repeat_protein expressed in the developing Xenopus nervous system .
16756962	0	XPA	0,3	ERCC1	107,112	XPA	ERCC1	7507	2067	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin_C in prostate_cancer cells : role of ERCC1 in homologous recombination repair .
22467238	0	XPA	30,33	HIF1a	0,5	XPA	HIF1a	7507	3091	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	HIF1a regulated expression of XPA contributes to cisplatin resistance in lung_cancer .
26578599	0	XPA	21,24	HMGB1	0,5	XPA	HMGB1	7507	3146	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells .
11058119	0	XPA	66,69	XAB1	27,31	XPA	XAB1	7507	11321	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA .
7876167	0	XPA	19,22	replication_protein_A	29,50	XPA	replication protein A	7507	6117	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	DNA repair protein XPA binds replication_protein_A -LRB- RPA -RRB- .
9753735	0	XPA	68,71	xeroderma_pigmentosum_group_A	37,66	XPA	xeroderma pigmentosum group A	7507	7507	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Mutational analysis of a function of xeroderma_pigmentosum_group_A -LRB- XPA -RRB- protein in strand-specific DNA repair .
16947863	0	XPB	32,35	ERCC3	55,60	XPB	ERCC3	2071	2071	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phenotypic heterogeneity in the XPB DNA helicase gene -LRB- ERCC3 -RRB- : xeroderma_pigmentosum without and with Cockayne_syndrome .
16786311	0	XPC	61,64	AtRAD4	74,80	XPC	AtRAD4	7508	831525(Tax:3702)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	CENTRIN2 interacts with the Arabidopsis homolog of the human XPC protein -LRB- AtRAD4 -RRB- and contributes to efficient synthesis-dependent repair of bulky DNA lesions .
8756644	0	XPC	42,45	HHR23B	0,6	XPC	HHR23B	7508	5887	Gene	Gene	protein|compound|START_ENTITY stimulates|dobj|protein stimulates|nsubj|END_ENTITY	HHR23B , a human Rad23 homolog , stimulates XPC protein in nucleotide excision repair in vitro .
9164480	0	XPC	0,3	HHR23B	24,30	XPC	HHR23B	7508	5887	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	XPC interacts with both HHR23B and HHR23A in vivo .
17705814	0	XPC	17,20	XPD	22,25	XPC	XPD	7508	2068	Gene	Gene	XRCC1|compound|START_ENTITY XRCC1|appos|END_ENTITY	Polymorphisms in XPC , XPD , XRCC1 , and XRCC3 DNA repair genes and lung_cancer risk in a population of northern Spain .
22893750	0	XPC	8,11	XPD	13,16	XPC	XPD	7508	2068	Gene	Gene	XRCC1|compound|START_ENTITY XRCC1|appos|END_ENTITY	Role of XPC , XPD , XRCC1 , GSTP genetic polymorphisms and Barrett 's _ esophagus in a cohort of Italian subjects .
22038723	0	XPC	102,105	Xeroderma_pigmentosum_complementary_group_C	57,100	XPC	Xeroderma pigmentosum complementary group C	7508	7508	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Clinicopathological significance and prognostic value of Xeroderma_pigmentosum_complementary_group_C -LRB- XPC -RRB- expression in sporadic_breast_cancer patients .
15322280	0	XPC	17,20	hHR23A	39,45	XPC	hHR23A	7508	5886	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction .
12713809	0	XPC	81,84	p53	17,20	XPC	p53	7508	7157	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage .
23669291	0	XPD	17,20	APE1	22,26	XPD	APE1	2068	328	Gene	Gene	XRCC1|compound|START_ENTITY XRCC1|appos|END_ENTITY	The influence of XPD , APE1 , XRCC1 , and NBS1 polymorphic variants on DNA repair in cells exposed to X-rays .
18470933	0	XPD	91,94	ERCC2	84,89	XPD	ERCC2	2068	2068	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 -LRB- XPD -RRB- mutations : cancer-prone_xeroderma_pigmentosum vs. non-cancer-prone_trichothiodystrophy .
9111200	0	XPD	114,117	ERCC2	119,124	XPD	ERCC2	100689272	100689272	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Restoration of preferential and strand specific gene repair in group 2 Chinese_hamster ovary mutants -LRB- UV5 -RRB- by the XPD _ -LRB- ERCC2 -RRB- gene .
9238033	0	XPD	93,96	ERCC2	98,103	XPD	ERCC2	2068	2068	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Xeroderma_pigmentosum and trichothiodystrophy are associated with different mutations in the XPD -LRB- ERCC2 -RRB- repair/transcription gene .
20708344	0	XPD	63,66	GSTM1	68,73	XPD	GSTM1	2068	2944	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	XPD	63,66	GSTT1	75,80	XPD	GSTT1	2068	2952	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	XPD	63,66	MLH1	88,92	XPD	MLH1	2068	4292	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	XPD	63,66	MSH2	82,86	XPD	MSH2	2068	4436	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
17705814	0	XPD	22,25	XPC	17,20	XPD	XPC	2068	7508	Gene	Gene	XRCC1|appos|START_ENTITY XRCC1|compound|END_ENTITY	Polymorphisms in XPC , XPD , XRCC1 , and XRCC3 DNA repair genes and lung_cancer risk in a population of northern Spain .
22893750	0	XPD	13,16	XPC	8,11	XPD	XPC	2068	7508	Gene	Gene	XRCC1|appos|START_ENTITY XRCC1|compound|END_ENTITY	Role of XPC , XPD , XRCC1 , GSTP genetic polymorphisms and Barrett 's _ esophagus in a cohort of Italian subjects .
20708344	0	XPD	63,66	XRCC3	56,61	XPD	XRCC3	2068	7517	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
24412486	0	XPF	74,77	Xeroderma_pigmentosum_complementation_group_F	27,72	XPF	Xeroderma pigmentosum complementation group F	2072	2072	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A nonsense mutation in the Xeroderma_pigmentosum_complementation_group_F -LRB- XPF -RRB- gene is associated with gastric_carcinogenesis .
19289372	0	XPG	0,3	BRCA1	105,110	XPG	BRCA1	2073	672	Gene	Gene	levels|compound|START_ENTITY modulate|nsubj|levels modulate|nmod|expression expression|compound|END_ENTITY	XPG mRNA expression levels modulate prognosis in resected non-small-cell lung_cancer in conjunction with BRCA1 and ERCC1 expression .
26833090	0	XPG	24,27	BRCA1	33,38	XPG	BRCA1	2073	672	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability .
22197612	0	XPG	78,81	ERCC1	89,94	XPG	ERCC1	2073	2067	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Trabectedin in patients with advanced non-small-cell_lung_cancer -LRB- NSCLC -RRB- with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum .
23255472	0	XPG	6,9	ERCC5	11,16	XPG	ERCC5	2073	2073	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Novel XPG -LRB- ERCC5 -RRB- mutations affect DNA repair and cell survival after ultraviolet but not oxidative stress .
24326185	0	XPG	31,34	RAD2	6,10	XPG	RAD2	2073	2237	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Yeast RAD2 , a homolog of human XPG , plays a key role in the regulation of the cell cycle and actin dynamics .
17466625	0	XPG	0,3	TFIIH	15,20	XPG	TFIIH	2073	2068	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	XPG stabilizes TFIIH , allowing transactivation of nuclear receptors : implications for Cockayne_syndrome in XP-G/CS patients .
12221096	0	XPLN	0,4	RhoA	47,51	XPLN	RhoA	50650	387	Gene	Gene	START_ENTITY|appos|factor factor|nmod|END_ENTITY	XPLN , a guanine_nucleotide exchange factor for RhoA and RhoB , but not RhoC .
24043828	0	XPLN	0,4	mTORC2	35,41	XPLN	mTORC2	50650	74343(Tax:10090)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	XPLN is an endogenous inhibitor of mTORC2 .
10871044	0	XPNPEP1	81,88	soluble_aminopeptidase_P	50,74	XPNPEP1	soluble aminopeptidase P	7511	7511	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning , chromosomal sublocalization of the human soluble_aminopeptidase_P gene -LRB- XPNPEP1 -RRB- to 10q25 .3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2 .
26753765	0	XPO-1	56,61	exportin-1	44,54	XPO-1	exportin-1	7514	7514	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Erratum to : KPT-330 , a potent and selective exportin-1 -LRB- XPO-1 -RRB- inhibitor , shows antitumor effects modulating the expression of cyclin_D1 and survivin in prostate_cancer models .
24766216	0	XPO1	69,73	exportin-1	57,67	XPO1	exportin-1	7514	7514	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Induction of p53-mediated transcription and apoptosis by exportin-1 -LRB- XPO1 -RRB- inhibition in mantle_cell_lymphoma .
26293807	0	XPO4	37,41	exportin-4	25,35	XPO4	exportin-4	64328	64328	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Copy number variation in exportin-4 -LRB- XPO4 -RRB- gene and its association with histological severity of non-alcoholic_fatty_liver_disease .
18348985	0	XRCC1	45,50	E2F1	0,4	XRCC1	E2F1	100689414	100758556	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair .
19031698	0	XRCC1	29,34	E2F1	1,5	XRCC1	E2F1	7515	1869	Gene	Gene	-RSB-|nummod|START_ENTITY endogenous|dobj|-RSB- endogenous|nsubj|upregulates upregulates|compound|END_ENTITY	-LSB- E2F1 upregulates endogenous XRCC1 expression -RSB- .
21757407	0	XRCC1	96,101	E2F1	0,4	XRCC1	E2F1	7515	1869	Gene	Gene	expression|compound|START_ENTITY upregulation|nmod|expression involved|nmod|upregulation involved|nsubjpass|END_ENTITY	E2F1 is involved in DNA single-strand break repair through cell-cycle-dependent upregulation of XRCC1 expression .
26314858	0	XRCC1	28,33	ERCC1	14,19	XRCC1	ERCC1	7515	2067	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|compound|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
26314858	0	XRCC1	28,33	ERCC2	21,26	XRCC1	ERCC2	7515	2068	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
22893750	0	XRCC1	18,23	GSTP	25,29	XRCC1	GSTP	7515	2950	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of XPC , XPD , XRCC1 , GSTP genetic polymorphisms and Barrett 's _ esophagus in a cohort of Italian subjects .
26314858	0	XRCC1	28,33	GSTP1	35,40	XRCC1	GSTP1	7515	2950	Gene	Gene	GSTT1|appos|START_ENTITY GSTT1|appos|END_ENTITY	Influences of ERCC1 , ERCC2 , XRCC1 , GSTP1 , GSTT1 , and MTHFR polymorphisms on clinical outcomes in gastric_cancer patients treated with EOF chemotherapy .
19208635	0	XRCC1	14,19	JWA	0,3	XRCC1	JWA	7515	10550	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks .
13679147	0	XRCC1	15,20	Tdp1	56,60	XRCC1	Tdp1	7515	55775	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of XRCC1 and tyrosyl_DNA_phosphodiesterase -LRB- Tdp1 -RRB- for the repair of topoisomerase I-mediated DNA lesions .
27026405	0	XRCC1	81,86	X-ray_repair_cross-complement_group_1	42,79	XRCC1	X-ray repair cross-complement group 1	7515	7515	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
27026405	0	XRCC1	81,86	p38	23,26	XRCC1	p38	7515	1432	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
26938431	0	XRCC2	35,40	XRCC3	42,47	XRCC2	XRCC3	7516	7517	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|appos|END_ENTITY	Association Studies Between XRCC1 , XRCC2 , XRCC3 Polymorphisms and Differentiated Thyroid_Carcinoma .
20708344	0	XRCC3	56,61	GSTM1	68,73	XRCC3	GSTM1	7517	2944	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	XRCC3	56,61	GSTT1	75,80	XRCC3	GSTT1	7517	2952	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	XRCC3	56,61	MLH1	88,92	XRCC3	MLH1	7517	4292	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	XRCC3	56,61	MSH2	82,86	XRCC3	MSH2	7517	4436	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
20708344	0	XRCC3	56,61	XPD	63,66	XRCC3	XPD	7517	2068	Gene	Gene	MSH3|appos|START_ENTITY MSH3|appos|END_ENTITY	Association between genetic polymorphisms in the XRCC1 , XRCC3 , XPD , GSTM1 , GSTT1 , MSH2 , MLH1 , MSH3 , and MGMT genes and radiosensitivity in breast_cancer patients .
26938431	0	XRCC3	42,47	XRCC2	35,40	XRCC3	XRCC2	7517	7516	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|appos|END_ENTITY	Association Studies Between XRCC1 , XRCC2 , XRCC3 Polymorphisms and Differentiated Thyroid_Carcinoma .
24984242	0	XRCC4	24,29	DNA_Ligase_IV	0,13	XRCC4	DNA Ligase IV	7518	3981	Gene	Gene	localization|nummod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	DNA_Ligase_IV regulates XRCC4 nuclear localization .
10047779	0	XRCC4	78,83	DNA_ligase_IV	11,24	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	stabilization|nmod|START_ENTITY evidence|nmod|stabilization Absence|dep|evidence Absence|nmod|protein protein|compound|END_ENTITY	Absence of DNA_ligase_IV protein in XR-1 cells : evidence for stabilization by XRCC4 .
11029705	0	XRCC4	144,149	DNA_ligase_IV	12,25	XRCC4	DNA ligase IV	821885(Tax:3702)	835822(Tax:3702)	Gene	Gene	homologue|nmod|START_ENTITY induced|nmod|homologue induced|nsubjpass|END_ENTITY	Arabidopsis DNA_ligase_IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4 .
12218164	0	XRCC4	60,65	DNA_ligase_IV	46,59	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of human autoantibodies to the DNA_ligase_IV / XRCC4 complex and mapping of an autoimmune_epitope to a potential regulatory region .
17290226	0	XRCC4	0,5	DNA_ligase_IV	6,19	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	START_ENTITY|parataxis|ligate ligate|nsubj|END_ENTITY	XRCC4 : DNA_ligase_IV can ligate incompatible DNA ends and can ligate across gaps .
18782835	0	XRCC4	89,94	DNA_ligase_IV	8,21	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	prevents|nmod|START_ENTITY prevents|nsubj|Loss Loss|nmod|END_ENTITY	Loss of DNA_ligase_IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF .
18952251	0	XRCC4	54,59	DNA_ligase_IV	40,53	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	dissociation|dep|START_ENTITY dissociation|nmod|END_ENTITY	E1B 55k-independent dissociation of the DNA_ligase_IV / XRCC4 complex by E4 34k during adenovirus_infection .
9242410	0	XRCC4	63,68	DNA_ligase_IV	12,25	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	protein|compound|START_ENTITY stimulated|nmod|protein stimulated|nsubj|Activity Activity|nmod|END_ENTITY	Activity of DNA_ligase_IV stimulated by complex formation with XRCC4 protein in mammalian cells .
9259561	0	XRCC4	49,54	DNA_ligase_IV	70,83	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA_ligase_IV .
9705934	0	XRCC4	23,28	DNA_ligase_IV	0,13	XRCC4	DNA ligase IV	7518	3981	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	DNA_ligase_IV binds to XRCC4 via a motif located between rather than within its BRCT domains .
21775435	0	XRCC4	0,5	XRCC4-like_factor	32,49	XRCC4	XRCC4-like factor	7518	79840	Gene	Gene	interactions|nummod|START_ENTITY interactions|nmod|END_ENTITY	XRCC4 protein interactions with XRCC4-like_factor -LRB- XLF -RRB- create an extended grooved scaffold for DNA ligation and double strand break repair .
21775435	0	XRCC4-like_factor	32,49	XRCC4	0,5	XRCC4-like factor	XRCC4	79840	7518	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	XRCC4 protein interactions with XRCC4-like_factor -LRB- XLF -RRB- create an extended grooved scaffold for DNA ligation and double strand break repair .
24462208	0	XRN2	16,20	PAXT-1	0,6	XRN2	PAXT-1	22803	187613(Tax:6239)	Gene	Gene	activity|compound|START_ENTITY promotes|dobj|activity promotes|nsubj|END_ENTITY	PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain .
12972573	0	XRad17	0,6	XChk1	41,46	XRad17	XChk1	398572(Tax:8355)	398191(Tax:8355)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	XRad17 is required for the activation of XChk1 but not XCds1 during checkpoint signaling in Xenopus .
11804777	0	XSIP1	70,75	Brachyury	22,31	XSIP1	Brachyury	100049718(Tax:8355)	399275(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1 .
22261149	0	XSeb4R	24,30	Sox3	50,54	XSeb4R	Sox3	398603(Tax:8355)	399335(Tax:8355)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The RNA-binding protein XSeb4R regulates maternal Sox3 at the posttranscriptional level during maternal-zygotic_transition in Xenopus .
16569644	0	XT-I	137,141	xylosyltransferase_I	57,77	XT-I	xylosyltransferase I	64131	64131	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cloning and recombinant expression of active full-length xylosyltransferase_I -LRB- XT-I -RRB- and characterization of subcellular localization of XT-I and XT-II .
21062743	0	XTP3-B	74,80	EDEM1	65,70	XTP3-B	EDEM1	27248	9695	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulum-associated degradation steps .
14570909	0	X_chromosome-linked_inhibitor_of_apoptosis	84,126	Grim	20,24	X chromosome-linked inhibitor of apoptosis	Grim	331	40014(Tax:7227)	Gene	Gene	ubiquitination|nmod|START_ENTITY promotes|dobj|ubiquitination promotes|nsubj|END_ENTITY	Unlike Diablo/smac , Grim promotes global ubiquitination and specific degradation of X_chromosome-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- and neither cause apoptosis .
10026129	0	X_inactive-specific_transcript	0,30	Xist	32,36	X inactive-specific transcript	Xist	338325(Tax:9913)	338325(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	X_inactive-specific_transcript -LRB- Xist -RRB- expression and X chromosome inactivation in the preattachment bovine embryo .
18841091	0	X_receptor	50,60	alpha-synuclein	14,29	X receptor	alpha-synuclein	9213	6622	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of alpha-synuclein expression by liver X_receptor ligands in vitro .
16432762	0	Xaf1	0,4	TNFalpha	24,32	Xaf1	TNFalpha	54739	7124	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Xaf1 can cooperate with TNFalpha in the induction of apoptosis , independently of interaction with XIAP .
16432762	0	Xaf1	0,4	XIAP	98,102	Xaf1	XIAP	54739	331	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	Xaf1 can cooperate with TNFalpha in the induction of apoptosis , independently of interaction with XIAP .
18695732	0	Xanf1	24,29	zyxin	72,77	Xanf1	zyxin	378542(Tax:8355)	100049724(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	-LSB- Transcriptional factor Xanf1 interacts with the focal adhesion protein zyxin in the early development of the Xenopus_laevis brain -RSB- .
25800347	0	Xanthine_oxidoreductase	0,23	IL1b	45,49	Xanthine oxidoreductase	IL1b	7498	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|secretion secretion|amod|END_ENTITY	Xanthine_oxidoreductase regulates macrophage IL1b secretion upon NLRP3 inflammasome activation .
25800347	0	Xanthine_oxidoreductase	0,23	NLRP3	65,70	Xanthine oxidoreductase	NLRP3	7498	114548	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|compound|END_ENTITY	Xanthine_oxidoreductase regulates macrophage IL1b secretion upon NLRP3 inflammasome activation .
15528468	0	Xanthine_oxidoreductase	0,23	cyclooxygenase-2	54,70	Xanthine oxidoreductase	cyclooxygenase-2	22436(Tax:10090)	19225(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Xanthine_oxidoreductase is an endogenous regulator of cyclooxygenase-2 .
9013932	0	Xbap	0,4	bagpipe	35,42	Xbap	bagpipe	378569(Tax:8355)	42537(Tax:7227)	Gene	Gene	START_ENTITY|appos|gene gene|acl|related related|nmod|END_ENTITY	Xbap , a vertebrate gene related to bagpipe , is expressed in developing craniofacial structures and in anterior gut muscle .
7925289	0	Xbra	15,19	eFGF	0,4	Xbra	eFGF	432248(Tax:8355)	378586(Tax:8355)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	eFGF regulates Xbra expression during Xenopus gastrulation .
9533956	0	Xcadherin-11	21,33	Xenopus_cadherin-11	0,19	Xcadherin-11	Xenopus cadherin-11	100337621(Tax:8355)	100337621(Tax:8355)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Xenopus_cadherin-11 -LRB- Xcadherin-11 -RRB- expression requires the Wg/Wnt signal .
11526510	0	Xcsk	58,62	Laloo	14,19	Xcsk	Laloo	378532(Tax:8355)	373700(Tax:8355)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Laloo by the Xenopus C-terminal_Src_kinase -LRB- Xcsk -RRB- during early vertebrate development .
10072389	0	Xe-Wee1	25,32	Mos	0,3	Xe-Wee1	Mos	398017(Tax:8355)	397924(Tax:8355)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus .
17981148	0	Xenopus_SH3_domain_binding_protein_5_like	28,69	xSH3BP5L	71,79	Xenopus SH3 domain binding protein 5 like	xSH3BP5L	495338(Tax:8355)	495338(Tax:8355)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a novel Xenopus_SH3_domain_binding_protein_5_like -LRB- xSH3BP5L -RRB- gene .
12050132	0	Xenopus_Smad-interacting_forkhead_transcription_factor	8,62	XFast-1	89,96	Xenopus Smad-interacting forkhead transcription factor	XFast-1	100337554(Tax:8355)	398070(Tax:8355)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	A novel Xenopus_Smad-interacting_forkhead_transcription_factor -LRB- XFast-3 -RRB- cooperates with XFast-1 in regulating gastrulation movements .
9533956	0	Xenopus_cadherin-11	0,19	Xcadherin-11	21,33	Xenopus cadherin-11	Xcadherin-11	100337621(Tax:8355)	100337621(Tax:8355)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Xenopus_cadherin-11 -LRB- Xcadherin-11 -RRB- expression requires the Wg/Wnt signal .
13679363	0	Xenopus_cold-inducible_RNA-binding_protein_2	0,44	ElrA	60,64	Xenopus cold-inducible RNA-binding protein 2	ElrA	379484(Tax:8355)	495680(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Xenopus_cold-inducible_RNA-binding_protein_2 interacts with ElrA , the Xenopus homolog of HuR , and inhibits deadenylation of specific mRNAs .
11306054	0	Xenopus_cytosolic_thyroid-hormone-binding_protein	20,69	xCTBP	71,76	Xenopus cytosolic thyroid-hormone-binding protein	xCTBP	398147(Tax:8355)	398147(Tax:8355)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of Xenopus_cytosolic_thyroid-hormone-binding_protein -LRB- xCTBP -RRB- with aldehyde dehydrogenase activity .
9428427	0	Xenopus_homeobox_gene_twin	4,30	goosecoid	57,66	Xenopus homeobox gene twin	goosecoid	373692(Tax:8355)	397752(Tax:8355)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	The Xenopus_homeobox_gene_twin mediates Wnt induction of goosecoid in establishment of Spemann 's organizer .
15771630	0	Xenopus_tudor_repeat	20,40	Xtr	15,18	Xenopus tudor repeat	Xtr	398252(Tax:8355)	398252(Tax:8355)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Xtr -LRB- Xenopus_tudor_repeat -RRB- in microtubule assembly around nucleus and karyokinesis during cleavage in Xenopus_laevis .
22038723	0	Xeroderma_pigmentosum_complementary_group_C	57,100	XPC	102,105	Xeroderma pigmentosum complementary group C	XPC	7508	7508	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Clinicopathological significance and prognostic value of Xeroderma_pigmentosum_complementary_group_C -LRB- XPC -RRB- expression in sporadic_breast_cancer patients .
24412486	0	Xeroderma_pigmentosum_complementation_group_F	27,72	XPF	74,77	Xeroderma pigmentosum complementation group F	XPF	2072	2072	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A nonsense mutation in the Xeroderma_pigmentosum_complementation_group_F -LRB- XPF -RRB- gene is associated with gastric_carcinogenesis .
12729560	0	Xfz7	56,60	Cdc42	71,76	Xfz7	Cdc42	378787(Tax:8355)	379055(Tax:8355)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Activation of Gbetagamma signaling downstream of Wnt-11 / Xfz7 regulates Cdc42 activity during Xenopus gastrulation .
16118211	0	Xic1	78,82	Proliferating_cell_nuclear_antigen	0,34	Xic1	Proliferating cell nuclear antigen	100137657(Tax:8355)	394328(Tax:8355)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Proliferating_cell_nuclear_antigen recruits cyclin-dependent kinase inhibitor Xic1 to DNA and couples its proteolysis to DNA polymerase switching .
16880568	0	Xis	76,79	X-ray_analysis_of_excisionase	45,74	Xis	X-ray analysis of excisionase	2703504(Tax:10710)	2703504(Tax:10710)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Crystallization , dehydration and preliminary X-ray_analysis_of_excisionase -LRB- Xis -RRB- proteins cooperatively bound to DNA .
21298085	0	Xist	16,20	RNF12	0,5	Xist	RNF12	7503	51132	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	RNF12 activates Xist and is essential for X chromosome inactivation .
10026129	0	Xist	32,36	X_inactive-specific_transcript	0,30	Xist	X inactive-specific transcript	338325(Tax:9913)	338325(Tax:9913)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	X_inactive-specific_transcript -LRB- Xist -RRB- expression and X chromosome inactivation in the preattachment bovine embryo .
10196469	0	XlCdc1	20,26	DNA_polymerase_delta	80,100	XlCdc1	DNA polymerase delta	379793(Tax:8355)	447518(Tax:8355)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Characterisation of XlCdc1 , a Xenopus homologue of the small -LRB- PolD2 -RRB- subunit of DNA_polymerase_delta ; identification of ten conserved regions I-X based on protein sequence comparisons across ten eukaryotic species .
16618813	0	Xmus101	23,30	Claspin	66,73	Xmus101	Claspin	398573(Tax:8355)	398192(Tax:8355)	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Direct requirement for Xmus101 in ATR-mediated phosphorylation of Claspin bound Chk1 during checkpoint signaling .
14568102	0	Xnr5	42,46	VegT	0,4	Xnr5	VegT	780748(Tax:8355)	397990(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	VegT activation of the early zygotic gene Xnr5 requires lifting of Tcf-mediated repression in the Xenopus blastula .
2402639	0	Xotch	0,5	notch	41,46	Xotch	notch	394367(Tax:8355)	31293(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Xotch , the Xenopus homolog of Drosophila notch .
14507918	0	Xp42	0,4	Mpk1	5,9	Xp42	Mpk1	398985(Tax:8355)	398985(Tax:8355)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Xp42 -LRB- Mpk1 -RRB- activation is not required for germinal vesicle_breakdown but for Raf complete phosphorylation in insulin-stimulated Xenopus oocytes .
9023105	0	Xp54	0,4	p54	50,53	Xp54	p54	399080(Tax:8355)	1656	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Xp54 , the Xenopus homologue of human RNA helicase p54 , is an integral component of stored mRNP particles in oocytes .
11950162	0	Xpa	98,101	p53	105,108	Xpa	p53	22590(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|dep|+ +|nummod|END_ENTITY	Assessment of carcinogenicity of di -LRB- 2-ethylhexyl -RRB- phthalate in a short-term assay using Xpa - / - and Xpa - / - / p53 + / - mice .
10749125	0	Xpc	95,98	Trp53	107,112	Xpc	Trp53	22591(Tax:10090)	22059(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Genotype-specific Trp53 mutational analysis in ultraviolet B radiation-induced skin_cancers in Xpc and Xpc Trp53 mutant mice .
19139260	0	Xpo1p	26,31	Mad1p	40,45	Xpo1p	Mad1p	853133(Tax:4932)	852794(Tax:4932)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast .
12853621	0	Xrcc3	72,77	Rad51C	44,50	Xrcc3	Rad51C	7517	5889	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Region and amino_acid residues required for Rad51C binding in the human Xrcc3 protein .
17241822	0	Xrcc4	57,62	DNA-PK	93,99	Xrcc4	DNA-PK	7518	5591	Gene	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Interaction of the Ku heterodimer with the DNA_ligase_IV / Xrcc4 complex and its regulation by DNA-PK .
15385968	0	Xrcc4	0,5	DNA_ligase_IV	86,99	Xrcc4	DNA ligase IV	7518	3981	Gene	Gene	physically|compound|START_ENTITY links|nsubj|physically links|nmod|END_ENTITY	Xrcc4 physically links DNA end processing by polynucleotide_kinase to DNA ligation by DNA_ligase_IV .
17241822	0	Xrcc4	57,62	DNA_ligase_IV	43,56	Xrcc4	DNA ligase IV	7518	3981	Gene	Gene	complex|amod|START_ENTITY Interaction|dep|complex Interaction|nmod|END_ENTITY	Interaction of the Ku heterodimer with the DNA_ligase_IV / Xrcc4 complex and its regulation by DNA-PK .
16336274	0	Xrpn10c	26,33	Scythe	102,108	Xrpn10c	Scythe	399421(Tax:8355)	379698(Tax:8355)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Unique proteasome subunit Xrpn10c is a specific receptor for the antiapoptotic ubiquitin-like protein Scythe .
22072981	0	Xrs2	18,22	Pch2	0,4	Xrs2	Pch2	851975(Tax:4932)	852484(Tax:4932)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Pch2 acts through Xrs2 and Tel1/ATM to modulate interhomolog bias and checkpoint function during meiosis .
19035338	0	Xtbx6	50,55	PMesogenin1_and_2	0,17	Xtbx6	PMesogenin1 and 2	394428(Tax:8355)	100216477(Tax:8355)	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	PMesogenin1_and_2 function directly downstream of Xtbx6 in Xenopus somitogenesis and myogenesis .
21314676	0	Xtr	0,3	FRGY2	61,66	Xtr	FRGY2	398252(Tax:8355)	397746(Tax:8355)	Gene	Gene	coexists|nsubj|START_ENTITY coexists|nmod|END_ENTITY	Xtr , a plural tudor domain-containing protein , coexists with FRGY2 both in cytoplasmic mRNP particle and germ plasm in Xenopus embryo : its possible role in translational regulation of maternal mRNAs .
15771630	0	Xtr	15,18	Xenopus_tudor_repeat	20,40	Xtr	Xenopus tudor repeat	398252(Tax:8355)	398252(Tax:8355)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of Xtr -LRB- Xenopus_tudor_repeat -RRB- in microtubule assembly around nucleus and karyokinesis during cleavage in Xenopus_laevis .
10769246	0	Xwnt11	0,6	Brachyury	30,39	Xwnt11	Brachyury	446915(Tax:8355)	399275(Tax:8355)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Xwnt11 is a target of Xenopus Brachyury : regulation of gastrulation movements via Dishevelled , but not through the canonical Wnt pathway .
18318733	0	Xwnt8	57,62	chordin	124,131	Xwnt8	chordin	397970(Tax:8355)	398045(Tax:8355)	Gene	Gene	causes|nsubj|START_ENTITY causes|nmod|END_ENTITY	VegT , eFGF and Xbra cause overall posteriorization while Xwnt8 causes eye-level restricted posteriorization in synergy with chordin in early Xenopus development .
27080258	0	Y-Box_binding_protein_1	73,96	Extracellular_signal-regulated_kinase	0,37	Y-Box binding protein 1	Extracellular signal-regulated kinase	4904	5594	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent phosphorylation of Y-Box_binding_protein_1 -LRB- YB-1 -RRB- enhances gene expression in granulosa cells in response to follicle stimulating hormone -LRB- FSH -RRB- .
12080043	0	Y-box-binding_protein-1	37,60	c-Myc	19,24	Y-box-binding protein-1	c-Myc	4904	4609	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|xcomp|regulate	p73 Interacts with c-Myc to regulate Y-box-binding_protein-1 expression .
8657568	0	Y-box_binding_protein	48,69	YB-1	71,75	Y-box binding protein	YB-1	4904	4904	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structural and functional analysis of the human Y-box_binding_protein -LRB- YB-1 -RRB- gene promoter .
20332234	0	Y-box_binding_protein-1	0,23	CD44	50,54	Y-box binding protein-1	CD44	4904	960	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Y-box_binding_protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal , mammosphere growth , and drug resistance .
20802512	0	Y-box_binding_protein-1	28,51	CD44	132,136	Y-box binding protein-1	CD44	4904	960	Gene	Gene	expression|nmod|START_ENTITY serine|nsubj|expression serine|advcl|increasing increasing|dobj|cells cells|nummod|END_ENTITY	The expression of activated Y-box_binding_protein-1 serine 102 mediates trastuzumab resistance in breast_cancer cells by increasing CD44 + cells .
17875215	0	Y-box_binding_protein-1	76,99	Epidermal_growth_factor_receptor	0,32	Y-box binding protein-1	Epidermal growth factor receptor	4904	1956	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- is transcriptionally induced by the Y-box_binding_protein-1 -LRB- YB-1 -RRB- and can be inhibited with Iressa in basal-like breast_cancer , providing a potential target for therapy .
20929136	0	Y-box_binding_protein-1	53,76	P-glycoprotein	95,109	Y-box binding protein-1	P-glycoprotein	4904	5243	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of changwelqing on nuclear translocation of Y-box_binding_protein-1 and expression of P-glycoprotein in human colon_cancer cell line with drug-resistance induced by vincristine -RSB- .
19318582	0	Y-box_binding_protein-1	47,70	Programmed_cell_death_protein_4	0,31	Y-box binding protein-1	Programmed cell death protein 4	4904	27250	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	Programmed_cell_death_protein_4 down-regulates Y-box_binding_protein-1 expression via a direct interaction with Twist1 to suppress cancer cell growth .
15072594	0	Y-box_binding_protein-1	41,64	YB-1	66,70	Y-box binding protein-1	YB-1	22608(Tax:10090)	22608(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Targeted disruption of one allele of the Y-box_binding_protein-1 -LRB- YB-1 -RRB- gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin_C .
16651443	0	Y-box_binding_protein-1	18,41	epidermal_growth_factor_receptor	72,104	Y-box binding protein-1	epidermal growth factor receptor	4904	1956	Gene	Gene	Disruption|nmod|START_ENTITY results|nsubj|Disruption results|nmod|suppression suppression|nmod|END_ENTITY	Disruption of the Y-box_binding_protein-1 results in suppression of the epidermal_growth_factor_receptor and HER-2 .
17595327	0	Y-box_binding_protein-1	159,182	epidermal_growth_factor_receptor	197,229	Y-box binding protein-1	epidermal growth factor receptor	4904	1956	Gene	Gene	START_ENTITY|advcl|inducing inducing|dobj|END_ENTITY	The phosphoinositide-dependent kinase-1 inhibitor 2-amino-N - -LSB- 4 - -LSB- 5 - -LRB- 2-phenanthrenyl -RRB- -3 - -LRB- trifluoromethyl -RRB- -1 H-pyrazol-1-yl -RSB- phenyl -RSB- - acetamide -LRB- OSU-03012 -RRB- prevents Y-box_binding_protein-1 from inducing epidermal_growth_factor_receptor .
15806160	0	Y-box_binding_protein_1	23,46	Akt	0,3	Y-box binding protein 1	Akt	4904	207	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt phosphorylates the Y-box_binding_protein_1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast_cancer cells .
21344396	0	Y-box_binding_protein_1	66,89	p53	0,3	Y-box binding protein 1	p53	4904	7157	Gene	Gene	Suppresses|nmod|START_ENTITY Suppresses|nsubj|END_ENTITY	p53 Suppresses lung_resistance-related_protein expression through Y-box_binding_protein_1 in the MCF-7 breast_tumor cell line .
9461420	0	Y-box_protein	34,47	YB-1	49,53	Y-box protein	YB-1	4904	4904	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the human Y-box_protein -LRB- YB-1 -RRB- gene .
11911949	0	Y1	55,57	neuropeptide_Y	40,54	Y1	neuropeptide Y	6084	4852	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Intron-mediated expression of the human neuropeptide_Y Y1 receptor .
26395079	0	Y1065	33,38	Vinculin	42,50	Y1065	Vinculin	1149211(Tax:187410)	7414	Gene	Gene	START_ENTITY|nmod|Bundling Bundling|compound|END_ENTITY	Correction to Phosphorylation at Y1065 in Vinculin Mediates Actin Bundling , Cell Spreading , and Mechanical Responses to Force .
25115937	0	Y1065	19,24	vinculin	28,36	Y1065	vinculin	1149211(Tax:187410)	7414	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation at Y1065 in vinculin mediates actin bundling , cell spreading , and mechanical responses to force .
20026268	0	Y1111	31,36	RTK	50,53	Y1111	RTK	1149255(Tax:187410)	5979	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	A negative regulatory role for Y1111 on the Tie-2 RTK .
16377459	0	Y5_receptor	19,30	neuropeptide-Y	4,18	Y5 receptor	neuropeptide-Y	4889	4852	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	The neuropeptide-Y Y5_receptor antagonist L-152 ,804 decreases alcohol self-administration in inbred alcohol-preferring -LRB- iP -RRB- rats .
9874177	0	Y5_receptor	96,107	peptide_YY	52,62	Y5 receptor	peptide YY	25340(Tax:10116)	287730(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Pharmacological profile of the rat intestinal crypt peptide_YY receptor vs. the recombinant rat Y5_receptor .
2785859	0	YAC-1	114,119	H-2	9,12	YAC-1	H-2	11870(Tax:10090)	111364(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Enhanced H-2 expression and T-cell-dependent rejection after intracerebral transplantation of the murine lymphoma YAC-1 .
2086452	0	YAC-1	31,36	interleukin-2	14,27	YAC-1	interleukin-2	11870(Tax:10090)	16183(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Production of interleukin-2 by YAC-1 cells stimulated with interleukin-1 and its augmentation of the natural killer activity .
25995376	0	YAP	60,63	AMOT	55,59	YAP	AMOT	10413	154796	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Endosomal regulation of contact inhibition through the AMOT : YAP pathway .
24101154	0	YAP	24,27	CDK1	0,4	YAP	CDK1	10413	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	CDK1 phosphorylation of YAP promotes mitotic_defects and cell motility and is essential for neoplastic transformation .
26906552	0	YAP	20,23	CIZ1	0,4	YAP	CIZ1	10413	25792	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CIZ1 interacts with YAP and activates its transcriptional activity in hepatocellular_carcinoma cells .
25492965	0	YAP	44,47	ERBB4	23,28	YAP	ERBB4	10413	2066	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Neuregulin_1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration .
24472438	0	YAP	34,37	ErbB4	71,76	YAP	ErbB4	10413	2066	Gene	Gene	binding|nmod|START_ENTITY regulator|amod|binding regulator|nmod|tyrosine tyrosine|amod|END_ENTITY	Molecular basis of the binding of YAP transcriptional regulator to the ErbB4 receptor tyrosine kinase .
25691658	0	YAP	0,3	Hoxa1	32,37	YAP	Hoxa1	22601(Tax:10090)	15394(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	YAP regulates the expression of Hoxa1 and Hoxc13 in mouse and human oral and skin epithelial tissues .
25261601	0	YAP	71,74	MT1DP	38,43	YAP	MT1DP	10413	326343	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Tumor suppressor long non-coding RNA , MT1DP is negatively regulated by YAP and Runx2 to inhibit FoxA1 in liver_cancer cells .
25918243	0	YAP	36,39	NOS1AP	0,6	YAP	NOS1AP	10413	9722	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	NOS1AP functionally associates with YAP to regulate Hippo signaling .
25918243	0	YAP	36,39	NOS1AP	0,6	YAP	NOS1AP	10413	9722	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	NOS1AP functionally associates with YAP to regulate Hippo signaling .
23613971	0	YAP	59,62	PTPN14	25,31	YAP	PTPN14	10413	5784	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity .
24367099	0	YAP	77,80	RHAMM	53,58	YAP	RHAMM	10413	3161	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast_cancer cell motility .
20048001	0	YAP	56,59	SCF	78,81	YAP	SCF	10413	4254	Gene	Gene	stability|compound|START_ENTITY regulates|dobj|stability regulates|nmod|END_ENTITY	A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -LRB- beta-TRCP -RRB- .
26668327	0	YAP	63,66	VE-cadherin	37,48	YAP	VE-cadherin	22601(Tax:10090)	12562(Tax:10090)	Gene	Gene	localization|compound|START_ENTITY localization|amod|END_ENTITY	The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling .
21399893	0	YAP	32,35	Yes-associated_protein	8,30	YAP	Yes-associated protein	10413	10413	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of Yes-associated_protein -LRB- YAP -RRB- expression is associated with estrogen and progesterone receptors negativity in invasive breast_carcinomas .
25337244	0	YAP	38,41	Yes-associated_protein	14,36	YAP	Yes-associated protein	10413	10413	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Yes-associated_protein -LRB- YAP -RRB- in breast phyllodes_tumor .
26254048	0	YAP	24,27	Yes-associated_protein	0,22	YAP	Yes-associated protein	10413	10413	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Yes-associated_protein -LRB- YAP -RRB- expression is involved in epithelial-mesenchymal transition in hepatocellular_carcinoma .
26617849	0	YAP	38,41	Yes-associated_protein	14,36	YAP	Yes-associated protein	10413	10413	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Yes-associated_protein -LRB- YAP -RRB- in metastatic breast_cancer .
7782338	0	YAP	34,37	Yes-associated_protein	39,61	YAP	Yes-associated protein	10413	10413	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the mammalian YAP -LRB- Yes-associated_protein -RRB- gene and its role in defining a novel protein module , the WW domain .
21685940	0	YAP	86,89	angiomotin-like-1	18,35	YAP	angiomotin-like-1	10413	154810	Gene	Gene	roles|nmod|START_ENTITY roles|acl|END_ENTITY	Opposing roles of angiomotin-like-1 and zona_occludens-2 on pro-apoptotic function of YAP .
26944315	0	YAP	48,51	yes-associated_protein	24,46	YAP	yes-associated protein	10413	10413	Gene	Gene	accumulation|appos|START_ENTITY accumulation|nmod|END_ENTITY	Nuclear accumulation of yes-associated_protein -LRB- YAP -RRB- maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression .
25473897	0	YAP1	68,72	FGF8	0,4	YAP1	FGF8	22601(Tax:10090)	14179(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	FGF8 promotes colorectal_cancer growth and metastasis by activating YAP1 .
25754111	0	YAP1	0,4	OCT4	15,19	YAP1	OCT4	22601(Tax:10090)	100846986	Gene	Gene	Activity|compound|START_ENTITY Activity|compound|END_ENTITY	YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and Vascular Mimicry of Stem-like Cells .
23791527	0	YAP1	15,19	SOX2	0,4	YAP1	SOX2	10413	6657	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage .
8313910	0	YAP1	0,4	TRX2	29,33	YAP1	TRX2	855005(Tax:4932)	853123(Tax:4932)	Gene	Gene	activation|nummod|START_ENTITY activation|nmod|END_ENTITY	YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces_cerevisiae to oxidative stress by hydroperoxides .
26426694	0	YAP1	36,40	Yes-Associated_Protein-1	10,34	YAP1	Yes-Associated Protein-1	10413	10413	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Decreased Yes-Associated_Protein-1 -LRB- YAP1 -RRB- Expression in Pediatric Hearts with Ventricular_Septal_Defects .
22558212	0	YAP1	0,4	c-Abl	14,19	YAP1	c-Abl	10413	25	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	YAP1 recruits c-Abl to protect angiomotin-like_1 from Nedd4-mediated degradation .
21856745	0	YAP1	42,46	miR-375	0,7	YAP1	miR-375	10413	494324	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung_cancer .
24356001	0	YAP1	81,85	miR-375	0,7	YAP1	miR-375	22601(Tax:10090)	723900(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY cells|acl|targeting inhibits|nsubj|cells inhibits|dep|END_ENTITY	miR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1 .
19470374	0	YB-1	21,25	HSP60	0,5	YB-1	HSP60	22608(Tax:10090)	15510(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HSP60 interacts with YB-1 and affects its polysome association and subcellular localization .
21392397	0	YB-1	29,33	K-RAS	20,25	YB-1	K-RAS	4904	3845	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation .
18335541	0	YB-1	22,26	MBNL1	0,5	YB-1	MBNL1	4904	4154	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	MBNL1 associates with YB-1 in cytoplasmic stress granules .
22249268	0	YB-1	11,15	MKNK1	0,5	YB-1	MKNK1	4904	8569	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition .
18851979	0	YB-1	139,143	RBBP6	0,5	YB-1	RBBP6	4904	5930	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain , leading to ubiquitination and proteosomal degradation of YB-1 .
24885403	0	YB-1	0,4	Sox2	15,19	YB-1	Sox2	4904	6657	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast_cancer cells .
23822148	0	YB-1	22,26	Tip110	0,6	YB-1	Tip110	4904	9733	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tip110 interacts with YB-1 and regulates each other 's function .
8657568	0	YB-1	71,75	Y-box_binding_protein	48,69	YB-1	Y-box binding protein	4904	4904	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structural and functional analysis of the human Y-box_binding_protein -LRB- YB-1 -RRB- gene promoter .
15072594	0	YB-1	66,70	Y-box_binding_protein-1	41,64	YB-1	Y-box binding protein-1	22608(Tax:10090)	22608(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Targeted disruption of one allele of the Y-box_binding_protein-1 -LRB- YB-1 -RRB- gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin_C .
9461420	0	YB-1	49,53	Y-box_protein	34,47	YB-1	Y-box protein	4904	4904	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the human Y-box_protein -LRB- YB-1 -RRB- gene .
25544376	0	YB-1	169,173	Y_box_binding_protein_1	144,167	YB-1	Y box binding protein 1	4904	4904	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Differential expression of the multidrug_resistance_1 -LRB- MDR1 -RRB- protein in prostate_cancer cells is independent from anticancer drug treatment and Y_box_binding_protein_1 -LRB- YB-1 -RRB- activity .
11175333	0	YB-1	58,62	p53	22,25	YB-1	p53	4904	7157	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Direct interaction of p53 with the Y-box binding protein , YB-1 : a mechanism for regulation of human gene expression .
25750333	0	YB1	25,28	Cyclin_A	0,8	YB1	Cyclin A	4904	890	Gene	Gene	Correlates|nmod|START_ENTITY Correlates|compound|END_ENTITY	Cyclin_A Correlates with YB1 , Progression and Resistance to Chemotherapy in Human Epithelial Ovarian Cancer .
24211838	0	YBX1	82,86	epidermal_growth_factor_receptor	26,58	YBX1	epidermal growth factor receptor	4904	1956	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Loss of CDH1 up-regulates epidermal_growth_factor_receptor via phosphorylation of YBX1 in non-small_cell_lung_cancer cells .
17213816	0	YC-1	0,4	HIF-1	14,19	YC-1	HIF-1	5937	3091	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	YC-1 inhibits HIF-1 expression in prostate_cancer cells : contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia .
22659114	0	YC-1	0,4	PKA	67,70	YC-1	PKA	24421(Tax:10116)	25636(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|pathway pathway|compound|END_ENTITY	YC-1 , a potent antithrombotic agent , induces lipolysis through the PKA pathway in rat visceral fat cells .
18059167	0	YC-1	32,36	Stat3	14,19	YC-1	Stat3	5937	6774	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular_carcinoma .
23123638	0	YC-1	21,25	VEGF	58,62	YC-1	VEGF	5937	7422	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	The anticancer agent YC-1 suppresses progestin-stimulated VEGF in breast_cancer cells and arrests breast_tumor development .
18197143	0	YC-1	0,4	heat_shock_protein_70	13,34	YC-1	heat shock protein 70	5937	3308	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	YC-1 induces heat_shock_protein_70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells .
23922702	0	YC-1	62,66	heat_shock_protein_70	12,33	YC-1	heat shock protein 70	24421(Tax:10116)	266759(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	The role of heat_shock_protein_70 in the protective effect of YC-1 on b-amyloid-induced toxicity in differentiated PC12 cells .
10578147	0	YC-1	61,65	soluble_guanylyl_cyclase	83,107	YC-1	soluble guanylyl cyclase	24421(Tax:10116)	497757(Tax:10116)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Release of nitric_oxide from endothelial cells stimulated by YC-1 , an activator of soluble_guanylyl_cyclase .
12818375	0	YC-1	58,62	tumor_necrosis_factor-alpha	16,43	YC-1	tumor necrosis factor-alpha	24421(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Potentiation of tumor_necrosis_factor-alpha expression by YC-1 in alveolar macrophages through a cyclic_GMP-independent pathway .
15013857	0	YC-1_and_PMC	25,37	iNOS	58,62	YC-1 and PMC	iNOS	24421(Tax:10116)	24599(Tax:10116)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Inhibitory mechanisms of YC-1_and_PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages .
8675026	0	YCL059c	58,65	KRR1	52,56	YCL059c	KRR1	850298(Tax:4932)	850298(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A novel cross-phylum family of proteins comprises a KRR1 -LRB- YCL059c -RRB- gene which is essential for viability of Saccharomyces_cerevisiae cells .
11571756	0	YCR020W-b	15,24	HTL1	4,8	YCR020W-b	HTL1	850384(Tax:4932)	850384(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The HTL1 gene -LRB- YCR020W-b -RRB- of Saccharomyces_cerevisiae is necessary for growth at 37 degrees C , and for the conservation of chromosome stability and fertility .
17441508	0	YDJ1	48,52	SGT2	0,4	YDJ1	SGT2	855661(Tax:4932)	854168(Tax:4932)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	SGT2 and MDY2 interact with molecular chaperone YDJ1 in Saccharomyces_cerevisiae .
9368028	0	YDR072c	116,123	IPT1	110,114	YDR072c	IPT1	851644(Tax:4932)	851644(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Synthesis of mannose - -LRB- inositol-P -RRB- 2-ceramide , the major sphingolipid in Saccharomyces_cerevisiae , requires the IPT1 -LRB- YDR072c -RRB- gene .
23298489	0	YES-associated_protein_1	0,24	Axl	122,125	YES-associated protein 1	Axl	10413	558	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	YES-associated_protein_1 promotes adenocarcinoma growth and metastasis through activation of the receptor_tyrosine_kinase Axl .
25561420	0	YES1	23,27	miR-17-5p	0,9	YES1	miR-17-5p	7525	406952	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	miR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian_cancer cell lines .
11113970	0	YGR224w	33,40	AZR1	18,22	YGR224w	AZR1	853139(Tax:4932)	853139(Tax:4932)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|gene gene|compound|END_ENTITY	Expression of the AZR1 gene -LRB- ORF YGR224w -RRB- , encoding a plasma membrane transporter of the major facilitator superfamily , is required for adaptation to acetic_acid and resistance to azoles in Saccharomyces_cerevisiae .
25631823	0	YHB1	65,69	Puf4p	33,38	YHB1	Puf4p	853149(Tax:4932)	852870(Tax:4932)	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Conditional regulation of Puf1p , Puf4p and Puf5p activity alters YHB1 mRNA stability for a rapid response to toxic nitric_oxide stress in yeast .
11097841	0	YHP1	62,66	Sln1	98,102	YHP1	Sln1	852062(Tax:4932)	854659(Tax:4932)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive regulation of transcription of homeoprotein-encoding YHP1 by the two-component regulator Sln1 in Saccharomyces_cerevisiae .
12435396	0	YKL-39	58,64	chitinase_3-like_2	33,51	YKL-39	chitinase 3-like 2	1117	1117	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Enhanced expression of the human chitinase_3-like_2 gene -LRB- YKL-39 -RRB- but not chitinase_3-like_1 gene -LRB- YKL-40 -RRB- in osteoarthritic cartilage .
24697115	0	YKL-40	45,51	CEA	57,60	YKL-40	CEA	1116	1084	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of combined testing of YKL-40 with CEA in Chinese colorectal_cancer patients .
18403759	0	YKL-40	39,45	CHI3L1	23,29	YKL-40	CHI3L1	1116	1116	Gene	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Effect of variation in CHI3L1 on serum YKL-40 level , risk of asthma , and lung function .
26040016	0	YKL-40	21,27	IL-4	105,109	YKL-40	IL-4	1116	3565	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of serum YKL-40 in anaphylactic rhinitis patients and association of serum YKL-40 with serum IL-4 and IFN-y -RSB- .
21478032	0	YKL-40	38,44	IL-6	0,4	YKL-40	IL-6	1116	3569	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	IL-6 , but not TNF-a , increases plasma YKL-40 in human subjects .
23197259	0	YKL-40	0,6	IL-8	15,19	YKL-40	IL-8	1116	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	YKL-40 induces IL-8 expression from bronchial epithelium via MAPK -LRB- JNK and ERK -RRB- and NF-kB pathways , causing bronchial smooth muscle proliferation and migration .
18556781	0	YKL-40	0,6	basic_fibroblast_growth_factor	101,131	YKL-40	basic fibroblast growth factor	1116	2247	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	YKL-40 , a marker of simian_immunodeficiency_virus encephalitis , modulates the biological activity of basic_fibroblast_growth_factor .
21978279	0	YKL40	83,88	pERK	14,18	YKL40	pERK	1116	9451	Gene	Gene	correlation|nmod|START_ENTITY Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of pERK and pAKT in pediatric high grade astrocytomas : correlation with YKL40 and prognostic significance .
16227198	0	YND1	0,4	CDC55	20,25	YND1	CDC55	856722(Tax:4932)	852685(Tax:4932)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity .
10409709	0	YND1	0,4	GDA1	21,25	YND1	GDA1	856722(Tax:4932)	856669(Tax:4932)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	YND1 , a homologue of GDA1 , encodes membrane-bound apyrase required for Golgi N - and O-glycosylation in Saccharomyces_cerevisiae .
18983998	0	YNK1	0,4	NM23	55,59	YNK1	NM23	853798(Tax:4932)	4830	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	YNK1 , the yeast homolog of human metastasis suppressor NM23 , is required for repair of UV radiation - and etoposide-induced DNA damage .
9837999	0	YOR005c	114,121	DNA_ligase_IV	146,159	YOR005c	DNA ligase IV	854166(Tax:4932)	3981	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces_cerevisiae open reading frame YOR005c , a homolog of mammalian DNA_ligase_IV .
18313299	0	YORKIE	25,31	SCALLOPED	0,9	YORKIE	SCALLOPED	37851(Tax:7227)	32536(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SCALLOPED interacts with YORKIE , the nuclear effector of the hippo tumor-suppressor pathway in Drosophila .
12777814	0	YPD1	53,57	SLN1	67,71	YPD1	SLN1	851363(Tax:4932)	854659(Tax:4932)	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	Co-crystallization of the yeast phosphorelay protein YPD1 with the SLN1 response-regulator domain and preliminary X-ray diffraction analysis .
9767597	0	YRR1	11,15	SNQ2	160,164	YRR1	SNQ2	854333(Tax:4932)	851574(Tax:4932)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	Yeast gene YRR1 , which is required for resistance to 4-nitroquinoline_N-oxide , mediates transcriptional activation of the multidrug resistance transporter gene SNQ2 .
15037601	0	YSK1	0,4	GM130	46,51	YSK1	GM130	10494	2801	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta .
10486217	0	YWHAG	76,81	14-3-3gamma	58,69	YWHAG	14-3-3gamma	7532	7532	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning , expression , and chromosomal mapping of the human 14-3-3gamma gene -LRB- YWHAG -RRB- to 7q11 .23 .
8812417	0	YWHAH	87,92	14-3-3_eta	64,74	YWHAH	14-3-3 eta	7533	7533	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural organization and chromosomal assignment of the human 14-3-3_eta chain gene -LRB- YWHAH -RRB- .
25158672	0	YY-1	123,127	HDAC5	106,111	YY-1	HDAC5	24919(Tax:10116)	84580(Tax:10116)	Gene	Gene	Function|compound|START_ENTITY Function|compound|END_ENTITY	Antithetical Regulation of a-Myosin Heavy Chain Between Fetal and Adult Heart_Failure Though Shuttling of HDAC5 Regulating YY-1 Function .
25775215	0	YY1	14,17	AKT	30,33	YY1	AKT	22632(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	IL-13 Induces YY1 through the AKT Pathway in Lung Fibroblasts .
7541038	0	YY1	39,42	Cyclophilin_A	0,13	YY1	Cyclophilin A	7528	5478	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Cyclophilin_A and FKBP12 interact with YY1 and alter its transcriptional activity .
15782117	0	YY1	27,30	HLJ1	73,77	YY1	HLJ1	7528	11080	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer_cell_invasion .
21345358	0	YY1	84,87	HLJ1	39,43	YY1	HLJ1	7528	11080	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Hepatitis_B_virus protein up-regulated HLJ1 expression via the transcription factor YY1 in human hepatocarcinoma cells .
19566924	0	YY1	12,15	HP1alpha	27,35	YY1	HP1alpha	7528	23468	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The role of YY1 in reduced HP1alpha gene expression in invasive human breast_cancer cells .
20525792	0	YY1	11,14	LEF-1	50,55	YY1	LEF-1	7528	51176	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	A role for YY1 in repression of dominant negative LEF-1 expression in colon_cancer .
17332747	0	YY1	11,14	Otx2	25,29	YY1	Otx2	22632(Tax:10090)	18424(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Acetylated YY1 regulates Otx2 expression in anterior_neuroectoderm at two cis-sites 90 kb apart .
19483472	0	YY1	20,23	PTEN	0,4	YY1	PTEN	7528	5728	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null_renal-cell_carcinoma .
15013809	0	YY1	64,67	Pax2	14,18	YY1	Pax2	22632(Tax:10090)	18504(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of Pax2 in the intermediate mesoderm is regulated by YY1 .
12628927	0	YY1	21,24	PcG	40,43	YY1	PcG	43819(Tax:7227)	40358(Tax:7227)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Transcription factor YY1 functions as a PcG protein in vivo .
16052488	0	YY1	26,29	PcG	45,48	YY1	PcG	43819(Tax:7227)	40358(Tax:7227)	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|END_ENTITY	Transient requirements of YY1 expression for PcG transcriptional repression and phenotypic rescue .
19960508	0	YY1	23,26	PcG	0,3	YY1	PcG	43819(Tax:7227)	40358(Tax:7227)	Gene	Gene	domain|compound|START_ENTITY recruitment|nmod|domain recruitment|compound|END_ENTITY	PcG recruitment by the YY1 REPO domain can be mediated by Yaf2 .
21253604	0	YY1	25,28	Polo-like_kinase_1	48,66	YY1	Polo-like kinase 1	7528	5347	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The transcription factor YY1 is a substrate for Polo-like_kinase_1 at the G2/M transition of the cell cycle .
25772619	0	YY1	0,3	UBIAD1	31,37	YY1	UBIAD1	7528	29914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	YY1 positively regulates human UBIAD1 expression .
16081784	0	YY1	147,150	YY1	32,35	YY1	YY1	7528	7528	Gene	Gene	role|nmod|START_ENTITY inhibition|dep|role inhibition|nmod|END_ENTITY	Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin 's _ lymphoma cell line via inhibition of NF-kappa_B activity : role of YY1 and Bcl-xL in Fas resistance and chemoresistance , respectively .
16081784	0	YY1	32,35	YY1	147,150	YY1	YY1	7528	7528	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|dep|role role|nmod|END_ENTITY	Rituximab-induced inhibition of YY1 and Bcl-xL expression in Ramos non-Hodgkin 's _ lymphoma cell line via inhibition of NF-kappa_B activity : role of YY1 and Bcl-xL in Fas resistance and chemoresistance , respectively .
16769183	0	YY1	23,26	Yin_Yang-1	11,21	YY1	Yin Yang-1	7528	7528	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for Yin_Yang-1 -LRB- YY1 -RRB- in the assembly of snRNA transcription complexes .
18542060	0	YY1	57,60	c-Myc	82,87	YY1	c-Myc	7528	4609	Gene	Gene	cooperating|nmod|START_ENTITY cooperating|xcomp|repress repress|xcomp|END_ENTITY	p300 provides a corepressor function by cooperating with YY1 and HDAC3 to repress c-Myc .
8855231	0	YY1	0,3	c-Myc	60,65	YY1	c-Myc	7528	4609	Gene	Gene	associate|nsubj|START_ENTITY associate|nmod|vivo vivo|nmod|manner manner|acl:relcl|depends depends|nmod|levels levels|amod|END_ENTITY	YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels .
9696045	0	YY1	0,3	c-Myc	16,21	YY1	c-Myc	7528	4609	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|dobj|function function|amod|END_ENTITY	YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc .
9696045	0	YY1	76,79	c-Myc	16,21	YY1	c-Myc	7528	4609	Gene	Gene	binding|nmod|START_ENTITY requiring|dobj|binding mechanism|acl|requiring inhibit|nmod|mechanism inhibit|dobj|function function|amod|END_ENTITY	YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc .
7769693	0	YY1	48,51	c-fos	34,39	YY1	c-fos	7528	2353	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB .
17434929	0	YY1	111,114	c-myc	59,64	YY1	c-myc	7528	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1 .
7565750	0	YY1	0,3	serum_response_factor	35,56	YY1	serum response factor	22632(Tax:10090)	20807(Tax:10090)	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|association association|nmod|END_ENTITY	YY1 facilitates the association of serum_response_factor with the c-fos serum response element .
8990171	0	YY1	0,3	vitamin_D_receptor	14,32	YY1	vitamin D receptor	7528	7421	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	YY1 regulates vitamin_D_receptor / retinoid_X_receptor mediated transactivation of the vitamin_D responsive osteocalcin gene .
25544376	0	Y_box_binding_protein_1	144,167	YB-1	169,173	Y box binding protein 1	YB-1	4904	4904	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Differential expression of the multidrug_resistance_1 -LRB- MDR1 -RRB- protein in prostate_cancer cells is independent from anticancer drug treatment and Y_box_binding_protein_1 -LRB- YB-1 -RRB- activity .
8071588	0	Yac-1	56,61	interleukin-2	109,122	Yac-1	interleukin-2	11870(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY perforin|dobj|activity perforin|nmod|stimulation stimulation|nmod|END_ENTITY	Macrophage precursor cells produce perforin and perform Yac-1 lytic activity in response to stimulation with interleukin-2 .
12706874	0	Yaf2	0,4	Myc	14,17	Yaf2	Myc	10138	4609	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|function function|compound|END_ENTITY	Yaf2 inhibits Myc biological function .
11593398	0	Yaf2	26,30	MycN	58,62	Yaf2	MycN	10138	4613	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of Yaf2 with the central region of MycN .
26452715	0	Yak1	12,16	AtYak1	26,32	Yak1	AtYak1	833590(Tax:3702)	833590(Tax:3702)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Arabidopsis Yak1 protein -LRB- AtYak1 -RRB- is a dual specificity protein kinase .
9373137	0	Yak1	154,158	PKY	37,40	Yak1	PKY	853300(Tax:4932)	10114	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and sequence of human PKY , a putative kinase with increased expression in multidrug-resistant cells , with homology to yeast protein kinase Yak1 .
12111211	0	Yan	0,3	Lozenge	14,21	Yan	Lozenge	33392(Tax:7227)	31883(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Yan regulates Lozenge during Drosophila eye development .
21102585	0	Yap	21,24	Mst1/2	0,6	Yap	Mst1/2	10413	4485;6788	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Mst1/2 signalling to Yap : gatekeeper for liver size and tumour development .
25336744	0	Yap	109,112	Nf2	21,24	Yap	Nf2	10413	4771	Gene	Gene	inhibiting|dobj|START_ENTITY regulates|advcl|inhibiting regulates|nsubj|END_ENTITY	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap .
26335201	0	Yap1	42,46	Amotl2a	0,7	Yap1	Amotl2a	561411(Tax:7955)	558920(Tax:7955)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Amotl2a interacts with the Hippo effector Yap1 and the Wnt/b-catenin effector Lef1 to control tissue size in zebrafish .
18086556	0	Yap1	96,100	FLR1	59,63	Yap1	FLR1	855005(Tax:4932)	852293(Tax:4932)	Gene	Gene	control|nmod|START_ENTITY involves|nmod|control involves|dobj|up-regulation up-regulation|nmod|END_ENTITY	Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1 , Rpn4 , Pdr3 , and Yrr1 .
23912082	0	Yap1	41,45	Flr1	25,29	Yap1	Flr1	855005(Tax:4932)	852293(Tax:4932)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The MFS-type efflux pump Flr1 induced by Yap1 promotes canthin-6-one resistance in yeast .
15135069	0	Yap1	114,118	GPX2	74,78	Yap1	GPX2	855005(Tax:4932)	852546(Tax:4932)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	Regulation of the yeast phospholipid hydroperoxide_glutathione peroxidase GPX2 by oxidative stress is mediated by Yap1 and Skn7 .
25846731	0	Yap1	86,90	MicroRNA-506	0,12	Yap1	MicroRNA-506	10413	574511	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-506 inhibits gastric_cancer proliferation and invasion by directly targeting Yap1 .
18280240	0	Yap1	0,4	c-Abl	24,29	Yap1	c-Abl	10413	25	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage .
26296316	0	Yap2	14,18	Rck1	45,49	Yap2	Rck1	852033(Tax:4932)	852719(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Inhibition of Yap2 activity by MAPKAP kinase Rck1 affects yeast tolerance to cadmium .
26276098	0	Yap8	36,40	Ufd2	20,24	Yap8	Ufd2	856329(Tax:4932)	851337(Tax:4932)	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	E4-Ubiquitin ligase Ufd2 stabilizes Yap8 and modulates arsenic stress responses independent of the U-box motif .
22570489	0	Yar1	0,4	Rps3	36,40	Yar1	Rps3	855837(Tax:4932)	855543(Tax:4932)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Yar1 protects the ribosomal protein Rps3 from aggregation .
24021814	0	Yar1	84,88	rpS3	49,53	Yar1	rpS3	855837(Tax:4932)	855543(Tax:4932)	Gene	Gene	ribosomal|nmod|START_ENTITY ribosomal|dobj|END_ENTITY	Crystal structure of the yeast ribosomal protein rpS3 in complex with its chaperone Yar1 .
2254303	0	Yb2	107,110	glutathione_S-transferase	132,157	Yb2	glutathione S-transferase	83807(Tax:10116)	58962(Tax:10116)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Isozyme specificity in the conversion of hepoxilin_A3 -LRB- HxA3 -RRB- into a glutathionyl_hepoxilin -LRB- HxA3-C -RRB- by the Yb2 subunit of rat liver glutathione_S-transferase .
15472720	0	Ydj1	49,53	Hsp40	43,48	Ydj1	Hsp40	855661(Tax:4932)	855661(Tax:4932)	Gene	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	Peptide substrate identification for yeast Hsp40 Ydj1 by screening the phage display library .
24626187	0	Yen1	46,50	Cdc14	0,5	Yen1	Cdc14	856764(Tax:4932)	850585(Tax:4932)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Cdc14 targets the Holliday junction resolvase Yen1 to the nucleus in early anaphase .
25910964	0	Yes-1	22,27	miR-203	0,7	Yes-1	miR-203	7525	406986	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral_cancer cells .
26426694	0	Yes-Associated_Protein-1	10,34	YAP1	36,40	Yes-Associated Protein-1	YAP1	10413	10413	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Decreased Yes-Associated_Protein-1 -LRB- YAP1 -RRB- Expression in Pediatric Hearts with Ventricular_Septal_Defects .
12535517	0	Yes-associated_protein	23,45	Akt	0,3	Yes-associated protein	Akt	10413	207	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt phosphorylates the Yes-associated_protein , YAP , to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis .
21364637	0	Yes-associated_protein	19,41	JNK	0,3	Yes-associated protein	JNK	10413	5599	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	JNK phosphorylates Yes-associated_protein -LRB- YAP -RRB- to regulate apoptosis .
12118366	0	Yes-associated_protein	0,22	Smad7	46,51	Yes-associated protein	Smad7	22601(Tax:10090)	4092	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Yes-associated_protein -LRB- YAP65 -RRB- interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling .
16596258	0	Yes-associated_protein	0,22	Smad7	46,51	Yes-associated protein	Smad7	10413	4092	Gene	Gene	START_ENTITY|nmod|relation relation|nmod|expression expression|amod|END_ENTITY	Yes-associated_protein -LRB- YAP65 -RRB- in relation to Smad7 expression in human pancreatic_ductal_adenocarcinoma .
21399893	0	Yes-associated_protein	8,30	YAP	32,35	Yes-associated protein	YAP	10413	10413	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of Yes-associated_protein -LRB- YAP -RRB- expression is associated with estrogen and progesterone receptors negativity in invasive breast_carcinomas .
25337244	0	Yes-associated_protein	14,36	YAP	38,41	Yes-associated protein	YAP	10413	10413	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Yes-associated_protein -LRB- YAP -RRB- in breast phyllodes_tumor .
26254048	0	Yes-associated_protein	0,22	YAP	24,27	Yes-associated protein	YAP	10413	10413	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Yes-associated_protein -LRB- YAP -RRB- expression is involved in epithelial-mesenchymal transition in hepatocellular_carcinoma .
26617849	0	Yes-associated_protein	14,36	YAP	38,41	Yes-associated protein	YAP	10413	10413	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of Yes-associated_protein -LRB- YAP -RRB- in metastatic breast_cancer .
7782338	0	Yes-associated_protein	39,61	YAP	34,37	Yes-associated protein	YAP	10413	10413	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Characterization of the mammalian YAP -LRB- Yes-associated_protein -RRB- gene and its role in defining a novel protein module , the WW domain .
17110958	0	Yes-associated_protein_1	4,28	p73	40,43	Yes-associated protein 1	p73	10413	7161	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	The Yes-associated_protein_1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73 .
12668611	0	Yfh1	79,83	frataxin	59,67	Yfh1	frataxin	851437(Tax:4932)	2395	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Iron use for haeme synthesis is under control of the yeast frataxin homologue -LRB- Yfh1 -RRB- .
12165564	0	Yfh1p	27,32	frataxin	10,18	Yfh1p	frataxin	851437(Tax:4932)	2395	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins .
9180083	0	Yfh1p	49,54	frataxin	78,86	Yfh1p	frataxin	851437(Tax:4932)	2395	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Regulation of mitochondrial iron accumulation by Yfh1p , a putative homolog of frataxin .
24497193	0	Yhc1	35,39	U1_snRNP	57,65	Yhc1	U1 snRNP	851005(Tax:4932)	26871	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Structure-function analysis of the Yhc1 subunit of yeast U1_snRNP and genetic interactions of Yhc1 with Mud2 , Nam8 , Mud1 , Tgs1 , U1 snRNA , SmD3 and Prp28 .
26786659	0	Yin-Yang-1	16,26	CCL4	94,98	Yin-Yang-1	CCL4	7528	6351	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A novel role of Yin-Yang-1 in pulmonary_tuberculosis through the regulation of the chemokine CCL4 .
11687571	0	Yin-Yang_1	0,10	interleukin-4	21,34	Yin-Yang 1	interleukin-4	7528	3565	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Yin-Yang_1 activates interleukin-4 gene expression in T cells .
16769183	0	Yin_Yang-1	11,21	YY1	23,26	Yin Yang-1	YY1	7528	7528	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for Yin_Yang-1 -LRB- YY1 -RRB- in the assembly of snRNA transcription complexes .
25954903	0	Yin_Yang-1	95,105	miR-34a	0,7	Yin Yang-1	miR-34a	7528	407040	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	miR-34a inhibits the migration and invasion of esophageal_squamous_cell_carcinoma by targeting Yin_Yang-1 .
19139378	0	Yin_Yang_1	86,96	B-type_natriuretic_peptide	28,54	Yin Yang 1	B-type natriuretic peptide	7528	4879	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Endothelin-stimulated human B-type_natriuretic_peptide gene expression is mediated by Yin_Yang_1 in association with histone_deacetylase_2 .
21666725	0	Yin_Yang_1	0,10	BRCA1	32,37	Yin Yang 1	BRCA1	7528	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Yin_Yang_1 positively regulates BRCA1 and inhibits mammary cancer formation .
21565439	0	Yin_Yang_1	0,10	COPD	63,67	Yin Yang 1	COPD	7528	260431	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Yin_Yang_1 expression and localisation in quadriceps muscle in COPD .
17431117	0	Yin_Yang_1	114,124	DR5	92,95	Yin Yang 1	DR5	7528	8795	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis : up-regulation of DR5 and inhibition of Yin_Yang_1 .
24469401	0	Yin_Yang_1	0,10	EAAT2	51,56	Yin Yang 1	EAAT2	7528	6506	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	Yin_Yang_1 is a repressor of glutamate_transporter EAAT2 , and it mediates manganese-induced decrease of EAAT2 expression in astrocytes .
24369345	0	Yin_Yang_1	0,10	Smad7	33,38	Yin Yang 1	Smad7	7528	4092	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Yin_Yang_1 -LRB- YY1 -RRB- synergizes with Smad7 to inhibit TGF-b signaling in the nucleus .
15870067	0	Yin_Yang_1	0,10	activator_protein_2	27,46	Yin Yang 1	activator protein 2	7528	7020	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Yin_Yang_1 cooperates with activator_protein_2 to stimulate ERBB2 gene expression in mammary cancer cells .
15567155	0	Yin_Yang_1	0,10	alpha-myosin_heavy_chain	21,45	Yin Yang 1	alpha-myosin heavy chain	24919(Tax:10116)	29605(Tax:10116)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Yin_Yang_1 represses alpha-myosin_heavy_chain gene expression in pathologic cardiac_hypertrophy .
19668226	0	Yin_Yang_1	0,10	androgen_receptor	53,70	Yin Yang 1	androgen receptor	7528	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	Yin_Yang_1 regulates the transcriptional activity of androgen_receptor .
19139378	0	Yin_Yang_1	86,96	histone_deacetylase_2	117,138	Yin Yang 1	histone deacetylase 2	7528	3066	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Endothelin-stimulated human B-type_natriuretic_peptide gene expression is mediated by Yin_Yang_1 in association with histone_deacetylase_2 .
15210108	0	Yin_Yang_1	0,10	p53	38,41	Yin Yang 1	p53	7528	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Yin_Yang_1 is a negative regulator of p53 .
26843327	0	Yin_Yang_1	0,10	p53	57,60	Yin Yang 1	p53	22632(Tax:10090)	22060(Tax:10090)	Gene	Gene	Survival|compound|START_ENTITY Survival|nmod|Downregulating Downregulating|nummod|END_ENTITY	Yin_Yang_1 Promotes Thymocyte Survival by Downregulating p53 .
17980704	0	Yin_Yang_1	0,10	p73	47,50	Yin Yang 1	p73	7528	7161	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|nmod|END_ENTITY	Yin_Yang_1 induces transcriptional activity of p73 through cooperation with E2F1 .
18029729	0	Yin_Yang_1	42,52	p73	26,29	Yin Yang 1	p73	7528	7161	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	Cooperative regulation of p73 promoter by Yin_Yang_1 and E2F1 .
22536409	0	Yin_Yang_1	77,87	prostate_stem_cell_antigen	36,62	Yin Yang 1	prostate stem cell antigen	7528	8000	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Positive and negative regulation of prostate_stem_cell_antigen expression by Yin_Yang_1 in prostate epithelial cell lines .
11861536	0	Yin_Yang_1	98,108	steroidogenic_acute_regulatory	18,48	Yin Yang 1	steroidogenic acute regulatory	24919(Tax:10116)	25557(Tax:10116)	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|gene gene|amod|END_ENTITY	Repression of the steroidogenic_acute_regulatory gene by the multifunctional transcription factor Yin_Yang_1 .
16357063	0	Yin_yang_1	0,10	histidine_decarboxylase	27,50	Yin yang 1	histidine decarboxylase	7528	3067	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	Yin_yang_1 -LRB- YY1 -RRB- represses histidine_decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site .
19208738	0	Yin_yang_1	0,10	snail	39,44	Yin yang 1	snail	7528	6615	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Yin_yang_1 regulates the expression of snail through a distal enhancer .
19380786	0	Ym1/2	0,5	Th2	15,18	Ym1/2	Th2	12655;104183	15111(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|amod|END_ENTITY	Ym1/2 promotes Th2 cytokine expression by inhibiting 12/15 -LRB- S -RRB- - lipoxygenase : identification of a novel pathway for regulating allergic_inflammation .
25779220	0	Yme1	67,71	Tim10	28,33	Yme1	Tim10	856135(Tax:4932)	856395(Tax:4932)	Gene	Gene	protects|nmod|START_ENTITY protects|dobj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
26182355	0	Yme1	67,71	Tim10	28,33	Yme1	Tim10	856135(Tax:4932)	856395(Tax:4932)	Gene	Gene	protects|nmod|START_ENTITY protects|dobj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
25779220	0	Yme1	67,71	Tim9	14,18	Yme1	Tim9	856135(Tax:4932)	856693(Tax:4932)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
26182355	0	Yme1	67,71	Tim9	14,18	Yme1	Tim9	856135(Tax:4932)	856693(Tax:4932)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Mitochondrial Tim9 protects Tim10 from degradation by the protease Yme1 .
18029035	0	Ymer	15,19	NF-kappaB	38,47	Ymer	NF-kappaB	152137	4790	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain .
12077334	0	Yng1p	0,5	Sas3p	32,37	Yng1p	Sas3p	854230(Tax:4932)	852228(Tax:4932)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|nmod|END_ENTITY	Yng1p modulates the activity of Sas3p as a component of the yeast NuA3 Hhistone acetyltransferase complex .
10940022	0	YopE	137,141	SycE	104,108	YopE	SycE	1449493(Tax:630)	1449492(Tax:630)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Competition between the Yops of Yersinia_enterocolitica for delivery into eukaryotic cells : role of the SycE chaperone binding domain of YopE .
8497188	0	YopE	87,91	SycE	0,4	YopE	SycE	1449493(Tax:630)	1449492(Tax:630)	Gene	Gene	secretion|nmod|START_ENTITY involved|nmod|secretion involved|advmod|END_ENTITY	SycE , a chaperone-like protein of Yersinia_enterocolitica involved in Ohe secretion of YopE .
10082567	0	Yor1p	81,86	multidrug_resistance_protein	113,141	Yor1p	multidrug resistance protein	853198(Tax:4932)	4363	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Mutational disruption of plasma membrane trafficking of Saccharomyces_cerevisiae Yor1p , a homologue of mammalian multidrug_resistance_protein .
22840522	0	Yorkie	49,55	Homeodomain-interacting_protein_kinase	0,38	Yorkie	Homeodomain-interacting protein kinase	37851(Tax:7227)	38070(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Homeodomain-interacting_protein_kinase regulates Yorkie activity to promote tissue growth .
25157415	0	Yorkie	15,21	Notch	0,5	Yorkie	Notch	37851(Tax:7227)	31293(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Notch inhibits Yorkie activity in Drosophila wing discs .
21311569	0	Yorkie	21,27	Wbp2	0,4	Yorkie	Wbp2	37851(Tax:7227)	39460(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway .
22895050	0	Ypk1	76,80	Slm1	25,29	Ypk1	Slm1	853733(Tax:4932)	854701(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. _ cerevisiae .
16055732	0	Ypk2	44,48	Tor2	0,4	Ypk2	Tor2	855130(Tax:4932)	853632(Tax:4932)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization .
18606009	0	Yps3p	52,57	Toll-like_receptor_2	66,86	Yps3p	Toll-like receptor 2	850812(Tax:4932)	24088(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Histoplasma_capsulatum yeast phase-specific protein Yps3p induces Toll-like_receptor_2 signaling .
12455997	0	Yuh1p	20,25	Rub1p	0,5	Yuh1p	Rub1p	853562(Tax:4932)	851717(Tax:4932)	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Rub1p processing by Yuh1p is required for wild-type levels of Rub1p conjugation to Cdc53p .
26885274	0	Ywhaz	53,58	miR-451	0,7	Ywhaz	miR-451	7534	574411	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	miR-451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal_cancer .
25774914	0	Yy1	0,3	Peg3	52,56	Yy1	Peg3	22632(Tax:10090)	18616(Tax:10090)	Gene	Gene	Effect|compound|START_ENTITY Effect|nmod|END_ENTITY	Yy1 Gene Dosage Effect and Bi-Allelic Expression of Peg3 .
26982741	0	Z-Dependent_Protease_Inhibitor	51,81	ZPI	83,86	Z-Dependent Protease Inhibitor	ZPI	51156	51156	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Single Nucleotide Variant rs2232710 in the Protein Z-Dependent_Protease_Inhibitor -LRB- ZPI , SERPINA10 -RRB- Gene Is Not Associated with Deep_Vein_Thrombosis .
20363751	0	ZAC1	48,52	Glut4	28,33	ZAC1	Glut4	25157(Tax:10116)	25139(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cardiomyocyte Glut4 expression by ZAC1 .
15246563	0	ZAG	36,39	zinc-alpha2-glycoprotein	10,34	ZAG	zinc-alpha2-glycoprotein	12007(Tax:10090)	12007(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of zinc-alpha2-glycoprotein -LRB- ZAG -RRB- on expression of uncoupling proteins in skeletal muscle and adipose tissue .
8103379	0	ZAG1	49,53	AGAMOUS	113,120	ZAG1	AGAMOUS	542244(Tax:4577)	827631(Tax:3702)	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Identification and molecular characterization of ZAG1 , the maize homolog of the Arabidopsis floral homeotic gene AGAMOUS .
15465036	0	ZAK	127,130	Transforming_growth_factor-beta	0,31	ZAK	Transforming growth factor-beta	51776	7040	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-beta induces the expression of ANF and hypertrophic growth in cultured cardiomyoblast cells through ZAK .
9126492	0	ZAN	84,87	zonadhesin	67,77	ZAN	zonadhesin	7455	22635(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene -LRB- ZAN -RRB- .
23255809	0	ZAP	0,3	ORF64	40,45	ZAP	ORF64	56829	1497174(Tax:33708)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	ZAP inhibits murine_gammaherpesvirus_68 ORF64 expression and is antagonized by RTA .
17701587	0	ZAP-70	87,93	CD38	94,98	ZAP-70	CD38	7535	952	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Multi-drug resistance mediated by P-glycoprotein overexpression is not correlated with ZAP-70 / CD38 expression in B-cell_chronic_lymphocytic_leukemia .
10419455	0	ZAP-70	93,99	Crk	109,112	ZAP-70	Crk	7535	1398	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins .
12600746	0	ZAP-70	48,54	ENX-2	27,32	ZAP-70	ENX-2	7535	2145	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Polycomb-group protein ENX-2 interacts with ZAP-70 .
7629168	0	ZAP-70	76,82	Grb2	140,144	ZAP-70	Grb2	7535	2885	Gene	Gene	phospholipase_C-gamma_1|amod|START_ENTITY phospholipase_C-gamma_1|nmod|END_ENTITY	Ligation of the T-cell_antigen_receptor -LRB- TCR -RRB- induces association of hSos1 , ZAP-70 , phospholipase_C-gamma_1 , and other phosphoproteins with Grb2 and the zeta-chain of the TCR .
10358158	0	ZAP-70	24,30	LAT	73,76	ZAP-70	LAT	22637(Tax:10090)	16797(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes .
17492476	0	ZAP-70	14,20	LAT	22,25	ZAP-70	LAT	7535	27040	Gene	Gene	SLP-76|compound|START_ENTITY SLP-76|appos|END_ENTITY	Prevalence of ZAP-70 , LAT , SLP-76 , and DNA_methyltransferase_1 expression in CD4 + T cells of patients with systemic_lupus_erythematosus .
9489702	0	ZAP-70	9,15	LAT	0,3	ZAP-70	LAT	7535	27040	Gene	Gene	tyrosine|amod|START_ENTITY substrate|amod|tyrosine END_ENTITY|dep|substrate	LAT : the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation .
10510363	0	ZAP-70	59,65	LFA-1	0,5	ZAP-70	LFA-1	7535	3683	Gene	Gene	kinase|compound|START_ENTITY involve|dobj|kinase involve|nsubj|signals signals|amod|LFA-1 LFA-1|amod|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
10510363	0	ZAP-70	59,65	LFA-1	9,14	ZAP-70	LFA-1	7535	3683	Gene	Gene	kinase|compound|START_ENTITY involve|dobj|kinase involve|nsubj|signals signals|amod|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
21200022	0	ZAP-70	35,41	LFA-1	13,18	ZAP-70	LFA-1	7535	3683	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes .
21200022	0	ZAP-70	35,41	LFA-1	82,87	ZAP-70	LFA-1	7535	3683	Gene	Gene	signals|nmod|START_ENTITY signals|xcomp|regulate regulate|dobj|expression expression|nmod|END_ENTITY	The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes .
21103055	0	ZAP-70	43,49	RhoH	0,4	ZAP-70	RhoH	7535	399	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling .
8638162	0	ZAP-70	21,27	SHP-1	31,36	ZAP-70	SHP-1	7535	5777	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling .
8761298	0	ZAP-70	72,78	Shc	52,55	ZAP-70	Shc	7535	6464	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	The aminoterminal phosphotyrosine binding domain of Shc associates with ZAP-70 and mediates TCR dependent gene activation .
12763134	0	ZAP-70	103,109	Syk	92,95	ZAP-70	Syk	7535	6850	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The inhibitory effect of anti-CD33 monoclonal antibodies on AML cell growth correlates with Syk and/or ZAP-70 expression .
10681590	0	ZAP-70	0,6	T_cell_antigen_receptor-induced_plasma_membrane_targeting_of_SOS_and_Vav	28,100	ZAP-70	T cell antigen receptor-induced plasma membrane targeting of SOS and Vav	7535	7409	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	ZAP-70 is essential for the T_cell_antigen_receptor-induced_plasma_membrane_targeting_of_SOS_and_Vav in T cells .
9151714	0	ZAP-70	31,37	Vav	4,7	ZAP-70	Vav	7535	7409	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	The Vav binding site -LRB- Y315 -RRB- in ZAP-70 is critical for antigen receptor-mediated signal transduction .
10510363	0	ZAP-70	59,65	zeta-associated_protein-70	31,57	ZAP-70	zeta-associated protein-70	7535	7535	Gene	Gene	kinase|compound|START_ENTITY kinase|amod|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
20846526	0	ZAP70	31,36	SHP2	0,4	ZAP70	SHP2	22637(Tax:10090)	19247(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells .
24647531	0	ZASP	0,4	Ankrd2	47,53	ZASP	Ankrd2	101927655	26287	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ZASP interacts with the mechanosensing protein Ankrd2 and p53 in the signalling network of striated muscle .
20850481	0	ZBP-89	0,6	Bak	16,19	ZBP-89	Bak	7707	578	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	ZBP-89 enhances Bak expression and causes apoptosis in hepatocellular_carcinoma cells .
11149424	0	ZBP-89	221,227	ODC	155,158	ZBP-89	ODC	22661(Tax:10090)	18263(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY receptor|parataxis|role receptor|nmod|inhibition inhibition|nmod|activity activity|appos|END_ENTITY	Retinoic_acid -LRB- RA -RRB- receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase -LRB- ODC -RRB- activity by retinoids : a potential role for trans-RA-induced ZBP-89 in ODC inhibition .
11149424	0	ZBP-89	221,227	ODC	231,234	ZBP-89	ODC	22661(Tax:10090)	18263(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Retinoic_acid -LRB- RA -RRB- receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase -LRB- ODC -RRB- activity by retinoids : a potential role for trans-RA-induced ZBP-89 in ODC inhibition .
16952553	0	ZBP-89	74,80	ataxia-telangiectasia_mutated	15,44	ZBP-89	ataxia-telangiectasia mutated	22661(Tax:10090)	11920(Tax:10090)	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Recruitment of ataxia-telangiectasia_mutated to the p21 -LRB- waf1 -RRB- promoter by ZBP-89 plays a role in mucosal protection .
19583777	0	ZBP-89	25,31	p16	43,46	ZBP-89	p16	7707	1029	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence .
12771217	0	ZBP-89	0,6	vimentin	17,25	ZBP-89	vimentin	7707	7431	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator , Sp1 .
19875459	0	ZBP89	72,77	IRS2	39,43	ZBP89	IRS2	7707	8660	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Neuronal insulin_receptor_substrate_2 -LRB- IRS2 -RRB- expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter .
24396871	0	ZBP89	51,56	Nur77	80,85	ZBP89	Nur77	7707	3164	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
24512852	0	ZBP89	51,56	Nur77	80,85	ZBP89	Nur77	7707	3164	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|promoter promoter|amod|END_ENTITY	Palmitate increases Nur77 expression by modulating ZBP89 and Sp1 binding to the Nur77 proximal promoter in pancreatic b-cells .
19875459	0	ZBP89	72,77	insulin_receptor_substrate_2	9,37	ZBP89	insulin receptor substrate 2	7707	8660	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Neuronal insulin_receptor_substrate_2 -LRB- IRS2 -RRB- expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter .
25749518	0	ZBRK1	0,5	VHL	43,46	ZBRK1	VHL	59348	7428	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	ZBRK1 , a novel tumor suppressor , activates VHL gene transcription through formation of a complex with VHL and p300 in renal_cancer .
26121690	0	ZBTB16	102,108	NLRP7	0,5	ZBTB16	NLRP7	7704	199713	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	NLRP7 , Involved in Hydatidiform Molar Pregnancy -LRB- HYDM1 -RRB- , Interacts with the Transcriptional Repressor ZBTB16 .
25609694	0	ZBTB2	0,5	PDK4	16,20	ZBTB2	PDK4	381990(Tax:10090)	27273(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	ZBTB2 increases PDK4 expression by transcriptional repression of RelA/p65 .
18669658	0	ZBTB20	20,26	alpha-fetoprotein	49,66	ZBTB20	alpha-fetoprotein	56490(Tax:10090)	11576(Tax:10090)	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|transcription transcription|amod|END_ENTITY	Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver .
22851713	0	ZBTB32	0,6	CIITA	36,41	ZBTB32	CIITA	58206(Tax:10090)	12265(Tax:10090)	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells .
25499219	0	ZBTB4	30,35	EZH2	46,50	ZBTB4	EZH2	57659	2146	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis .
19448668	0	ZBTB4	104,109	HIPK2	25,30	ZBTB4	HIPK2	57659	28996	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4 .
11713281	0	ZEB	30,33	p73	44,47	ZEB	p73	21417(Tax:10090)	22062(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation .
22190929	0	ZEB1	49,53	Androgen_Receptor	0,17	ZEB1	Androgen Receptor	6935	367	Gene	Gene	Factor|compound|START_ENTITY Transcription|nmod|Factor Transcription|compound|END_ENTITY	Androgen_Receptor Regulates Transcription of the ZEB1 Transcription Factor .
25910959	0	ZEB1	33,37	CRTAM	0,5	ZEB1	CRTAM	6935	56253	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	CRTAM is negatively regulated by ZEB1 in T cells .
25155634	0	ZEB1	65,69	Discoidin_domain_receptor_1	0,27	ZEB1	Discoidin domain receptor 1	6935	780	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Discoidin_domain_receptor_1 is a novel transcriptional target of ZEB1 in breast epithelial cells undergoing H-Ras-induced epithelial to mesenchymal transition .
20418909	0	ZEB1	0,4	E-cadherin	15,25	ZEB1	E-cadherin	6935	999	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1 .
20625840	0	ZEB1	76,80	E-cadherin	97,107	ZEB1	E-cadherin	6935	999	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Knockdown of thrombomodulin enhances HCC cell migration through increase of ZEB1 and decrease of E-cadherin gene expression .
23890107	0	ZEB1	21,25	GLI2	0,4	ZEB1	GLI2	6935	2736	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells .
24756066	0	ZEB1	91,95	GRHL2	18,23	ZEB1	GRHL2	6935	79977	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of GRHL2 inhibits the proliferation of colorectal_cancer cells by targeting ZEB1 .
22147512	0	ZEB1	85,89	HDAC1	36,41	ZEB1	HDAC1	6935	3065	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic_cancer .
26609108	0	ZEB1	27,31	MAPK-Interacting_Protein_Kinases	43,75	ZEB1	MAPK-Interacting Protein Kinases	6935	538	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Differential Regulation of ZEB1 and EMT by MAPK-Interacting_Protein_Kinases -LRB- MNK -RRB- and eIF4E in Pancreatic_Cancer .
26498682	0	ZEB1	123,127	MiR-652	0,7	ZEB1	MiR-652	6935	724022	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-652 inhibits acidic microenvironment-induced epithelial-mesenchymal transition of pancreatic_cancer cells by targeting ZEB1 .
26383522	0	ZEB1	108,112	Pituitary_tumor-transforming_gene_1	0,35	ZEB1	Pituitary tumor-transforming gene 1	6935	9232	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Pituitary_tumor-transforming_gene_1 enhances metastases of cervical_cancer cells through miR-3666-regulated ZEB1 .
17391671	0	ZEB1	25,29	Plakophilin_3	51,64	ZEB1	Plakophilin 3	6935	11187	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	The transcription factor ZEB1 -LRB- deltaEF1 -RRB- represses Plakophilin_3 during human cancer progression .
25358403	0	ZEB1	31,35	ROCK1	37,42	ZEB1	ROCK1	6935	6093	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Clinical significance of mTOR , ZEB1 , ROCK1 expression in lung tissues of pulmonary_fibrosis patients .
26882471	0	ZEB1	0,4	VEGF	17,21	ZEB1	VEGF	6935	7422	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast_Cancer .
23318438	0	ZEB1	40,44	WASF3	0,5	ZEB1	WASF3	6935	10810	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	WASF3 regulates miR-200 inactivation by ZEB1 through suppression of KISS1 leading to increased invasiveness in breast_cancer cells .
22095522	0	ZEB1	63,67	Zinc_finger_E-box_Binding_homeobox_1	25,61	ZEB1	Zinc finger E-box Binding homeobox 1	6935	6935	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of Zinc_finger_E-box_Binding_homeobox_1 -LRB- ZEB1 -RRB- in human gastric_cancer .
22391641	0	ZEB1	72,76	androgen_receptor	87,104	ZEB1	androgen receptor	6935	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Androgen_receptor is overexpressed in boys with severe hypospadias , and ZEB1 regulates androgen_receptor expression in human foreskin cells .
25160502	0	ZEB1	53,57	androgen_receptor	16,33	ZEB1	androgen receptor	6935	367	Gene	Gene	expression|nummod|START_ENTITY regulates|dobj|expression regulates|nsubj|presence presence|nmod|elements elements|compound|END_ENTITY	The presence of androgen_receptor elements regulates ZEB1 expression in the absence of androgen_receptor .
25160502	0	ZEB1	53,57	androgen_receptor	87,104	ZEB1	androgen receptor	6935	367	Gene	Gene	expression|nummod|START_ENTITY expression|nmod|absence absence|nmod|END_ENTITY	The presence of androgen_receptor elements regulates ZEB1 expression in the absence of androgen_receptor .
18622689	0	ZEB1	18,22	deltaEF1	24,32	ZEB1	deltaEF1	6935	6935	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Expression of the ZEB1 -LRB- deltaEF1 -RRB- transcription factor in human : additional insights .
25358403	0	ZEB1	31,35	mTOR	25,29	ZEB1	mTOR	6935	21977(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Clinical significance of mTOR , ZEB1 , ROCK1 expression in lung tissues of pulmonary_fibrosis patients .
26940738	0	ZEB1	89,93	miR-1271	0,8	ZEB1	miR-1271	6935	100302203	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-1271 inhibits migration , invasion and epithelial-mesenchymal transition by targeting ZEB1 and TWIST1 in pancreatic_cancer cells .
27020592	0	ZEB1	116,120	miR-204	108,115	ZEB1	miR-204	6935	406987	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204 / ZEB1 axis in nasopharyngeal_carcinoma .
19194497	0	ZEB1	0,4	p63	11,14	ZEB1	p63	6935	8626	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia .
17029218	0	ZEB1	63,67	p73	40,43	ZEB1	p73	6935	7161	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	The presence of an intronic deletion in p73 and high levels of ZEB1 alter the TAp73/DeltaTAp73 ratio in colorectal_carcinomas .
25797260	0	ZEB2	119,123	MicroRNA-200a	0,13	ZEB2	MicroRNA-200a	9839	406983	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular_carcinoma by decreasing ZEB2 .
22311119	0	ZEB2	90,94	MicroRNA-200b	0,13	ZEB2	MicroRNA-200b	9839	406984	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-200b regulates cell proliferation , invasion , and migration by directly targeting ZEB2 in gastric_carcinoma .
26935975	0	ZEB2	87,91	MicroRNA-200c	0,13	ZEB2	MicroRNA-200c	9839	406985	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-200c inhibits the metastasis of non-small_cell_lung_cancer cells by targeting ZEB2 , an epithelial-mesenchymal transition regulator .
25818166	0	ZEB2	0,4	TGF-b1	38,44	ZEB2	TGF-b1	9839	7040	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	ZEB2 promotes vasculogenic_mimicry by TGF-b1 induced epithelial-to-mesenchymal transition in hepatocellular_carcinoma .
24914372	0	ZEB2	82,86	miR-132	0,7	ZEB2	miR-132	9839	406921	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-132 inhibits colorectal_cancer_invasion and metastasis via directly targeting ZEB2 .
25008569	0	ZEB2	16,20	miR-141	0,7	ZEB2	miR-141	9839	406933	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-141 targets ZEB2 to suppress HCC progression .
20682777	0	ZEB2	121,125	zinc_finger_E-box-binding_homeobox_2	83,119	ZEB2	zinc finger E-box-binding homeobox 2	9839	9839	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Growth_hormone -LRB- GH -RRB- - dependent expression of a natural antisense transcript induces zinc_finger_E-box-binding_homeobox_2 -LRB- ZEB2 -RRB- in the glomerular podocyte : a novel action of gh with implications for the pathogenesis of diabetic_nephropathy .
25052237	0	ZEB2	111,115	zinc_finger_E-box-binding_homeobox_2	73,109	ZEB2	zinc finger E-box-binding homeobox 2	9839	9839	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	miR-200c modulates ovarian_cancer cell metastasis potential by targeting zinc_finger_E-box-binding_homeobox_2 -LRB- ZEB2 -RRB- expression .
11779640	0	ZF5128	73,79	Kruppel_type_zinc_finger_protein	89,121	ZF5128	Kruppel type zinc finger protein	25799	57209	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Nucleotide sequence and cell cycle-associated differential expression of ZF5128 , a novel Kruppel_type_zinc_finger_protein gene .
26506418	0	ZFAS1	20,25	CDK1	41,45	ZFAS1	CDK1	441951	983	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal_cancer .
15908750	0	ZFHX1B	110,116	zinc_finger_homeo_box_1B	79,103	ZFHX1B	zinc finger homeo box 1B	9839	9839	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genitourinary_anomalies in Mowat-Wilson_syndrome with deletion/mutation in the zinc_finger_homeo_box_1B gene -LRB- ZFHX1B -RRB- .
26112950	0	ZFHX3	50,55	zinc_finger_homeobox_3	26,48	ZFHX3	zinc finger homeobox 3	463	463	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rs7193343 polymorphism in zinc_finger_homeobox_3 -LRB- ZFHX3 -RRB- gene and atrial_fibrillation : an updated meta-analysis of 10 case-control comparisons .
24440720	0	ZFHX4	0,5	CHD4	42,46	ZFHX4	CHD4	79776	1108	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state .
18237746	0	ZFP-42	118,124	REX1	112,116	ZFP-42	REX1	132625	132625	Gene	Gene	cells|appos|START_ENTITY cells|nummod|END_ENTITY	Transcriptional activation of the suppressor_of_cytokine_signaling-3 -LRB- SOCS-3 -RRB- gene via STAT3 is increased in F9 REX1 -LRB- ZFP-42 -RRB- knockout teratocarcinoma stem cells relative to wild-type cells .
15629158	0	ZFP161	93,99	ZNF295	58,64	ZFP161	ZNF295	7541	49854	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161 .
26546680	0	ZFP36	57,62	TNF	33,36	ZFP36	TNF	7538	7124	Gene	Gene	control|appos|START_ENTITY control|nmod|END_ENTITY	Negative feed-forward control of TNF by tristetraprolin -LRB- ZFP36 -RRB- is limited by the mitogen-activated protein kinase phosphatase , DUSP1 : implications for regulation by glucocorticoids .
25014217	0	ZFP36L1	72,79	BCL2	35,39	ZFP36L1	BCL2	677	596	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells .
22110054	0	ZFP568	52,58	TRIM28	0,6	ZFP568	TRIM28	243905(Tax:10090)	21849(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues .
24469060	0	ZFP57	35,40	IGF2	49,53	ZFP57	IGF2	346171	3481	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The stem cell transcription factor ZFP57 induces IGF2 expression to promote anchorage-independent growth in cancer cells .
25448600	0	ZHX1	61,65	MiR-199a-3p	0,11	ZHX1	MiR-199a-3p	11244	406977	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MiR-199a-3p promotes gastric_cancer progression by targeting ZHX1 .
14741719	0	ZHX1	69,73	interleukin-2	94,107	ZHX1	interleukin-2	22770(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	A mechanism of induction of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene expression by interleukin-2 .
12527199	0	ZHX1	105,109	zinc-fingers_and_homeoboxes_1	74,103	ZHX1	zinc-fingers and homeoboxes 1	22770(Tax:10090)	22770(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene .
14741719	0	ZHX1	69,73	zinc-fingers_and_homeoboxes_1	38,67	ZHX1	zinc-fingers and homeoboxes 1	22770(Tax:10090)	22770(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A mechanism of induction of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene expression by interleukin-2 .
18194454	0	ZHX2	0,4	alpha-fetoprotein	23,40	ZHX2	alpha-fetoprotein	22882	174	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|expression expression|amod|END_ENTITY	ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines .
14981711	0	ZIC1	109,113	zinc_finger_protein_of_cerebellum_1	72,107	ZIC1	zinc finger protein of cerebellum 1	22771(Tax:10090)	22771(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Joubert_syndrome : a haplotype segregation strategy and exclusion of the zinc_finger_protein_of_cerebellum_1 -LRB- ZIC1 -RRB- gene .
12031344	0	ZIF268	57,63	NGFI-A	65,71	ZIF268	NGFI-A	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Anatomical and temporal differences in the regulation of ZIF268 -LRB- NGFI-A -RRB- protein in the hamster and mouse suprachiasmatic nucleus .
26556796	0	ZINC_FINGER_OF_ARABIDOPSIS_THALIANA12	0,37	FER-LIKE_IRON_DEFICIENCY-INDUCED_TRANSCRIPTION_FACTOR	61,114	ZINC FINGER OF ARABIDOPSIS THALIANA12	FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR	836103(Tax:3702)	817362(Tax:3702)	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	ZINC_FINGER_OF_ARABIDOPSIS_THALIANA12 -LRB- ZAT12 -RRB- Interacts with FER-LIKE_IRON_DEFICIENCY-INDUCED_TRANSCRIPTION_FACTOR -LRB- FIT -RRB- Linking Iron_Deficiency and Oxidative Stress Responses .
24576911	0	ZIP14	101,106	Interleukin-6	0,13	ZIP14	Interleukin-6	23516	3569	Gene	Gene	up-regulation|nmod|START_ENTITY implications|nmod|up-regulation accumulation|dep|implications enhances|dobj|accumulation enhances|nsubj|END_ENTITY	Interleukin-6 enhances manganese accumulation in SH-SY5Y cells : implications of the up-regulation of ZIP14 and the down-regulation of ZnT10 .
25862412	0	ZIP14	56,61	Prion_protein	0,13	ZIP14	Prion protein	213053(Tax:10090)	19122(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Prion_protein functions as a ferrireductase partner for ZIP14 and DMT1 .
26623077	0	ZIP14	40,45	SLC39a14	47,55	ZIP14	SLC39a14	23516	23516	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression of the zinc transporter ZIP14 -LRB- SLC39a14 -RRB- is affected by weight_loss and metabolic status and associates with PPARy in human adipose tissue and 3T3-L1 pre-adipocytes .
25428902	0	ZIP14	13,18	slc39A14	20,28	ZIP14	slc39A14	213053(Tax:10090)	213053(Tax:10090)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of ZIP14 -LRB- slc39A14 -RRB- on intestinal zinc processing and barrier function .
25921144	0	ZIP4	50,54	Zinc_Transporters	31,48	ZIP4	Zinc Transporters	55630	10463	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Expression Profile Analysis of Zinc_Transporters -LRB- ZIP4 , ZIP9 , ZIP11 , ZnT9 -RRB- in Gliomas and their Correlation with IDH1 Mutation Status .
26133979	0	ZIP5	30,34	SLC39A5	36,43	ZIP5	SLC39A5	283375	283375	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Knockdown of zinc transporter ZIP5 -LRB- SLC39A5 -RRB- expression significantly inhibits human esophageal_cancer progression .
26133979	0	ZIP5	30,34	SLC39A5	36,43	ZIP5	SLC39A5	283375	283375	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Knockdown of zinc transporter ZIP5 -LRB- SLC39A5 -RRB- expression significantly inhibits human esophageal_cancer progression .
15705588	0	ZIP7	4,8	Slc39a7	15,22	ZIP7	Slc39a7	7922	7922	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The ZIP7 gene -LRB- Slc39a7 -RRB- encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus .
15367680	0	ZIP_kinase	47,57	Death-associated_protein	0,24	ZIP kinase	Death-associated protein	1613	1611	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|kinase kinase|amod|END_ENTITY	Death-associated_protein kinase phosphorylates ZIP_kinase , forming a unique kinase hierarchy to activate its cell death functions .
10667597	0	ZK7	0,3	vascular_endothelial_growth_factor	45,79	ZK7	vascular endothelial growth factor	7678	7422	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	ZK7 , a novel zinc finger gene , is induced by vascular_endothelial_growth_factor and inhibits apoptotic death in hematopoietic cells .
21949845	0	ZMIZ1	0,5	androgen_receptor	58,75	ZMIZ1	androgen receptor	57178	367	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	ZMIZ1 preferably enhances the transcriptional activity of androgen_receptor with short polyglutamine tract .
24169522	0	ZMPSTE24	4,12	FACE1	14,19	ZMPSTE24	FACE1	10269	10269	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	New ZMPSTE24 -LRB- FACE1 -RRB- mutations in patients affected with restrictive_dermopathy or related progeroid syndromes and mutation update .
20331974	0	ZMYND8	50,56	RCOR2	8,13	ZMYND8	RCOR2	733267(Tax:8355)	431821(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Xenopus RCOR2 -LRB- REST_corepressor_2 -RRB- interacts with ZMYND8 , which is involved in neural differentiation .
1427907	0	ZNF117	43,49	HPF9	51,55	ZNF117	HPF9	51351	51351	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the human KRAB finger gene ZNF117 -LRB- HPF9 -RRB- to chromosome 7q11 .2 .
17297437	0	ZNF143	0,6	p73	22,25	ZNF143	p73	7702	7161	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes .
9096764	0	ZNF179	31,37	brain_finger_protein	4,24	ZNF179	brain finger protein	7732	7732	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The brain_finger_protein gene -LRB- ZNF179 -RRB- , a member of the RING finger family , maps within the Smith-Magenis_syndrome region at 17p11 .2 .
11279031	0	ZNF202	29,35	ABCA1	108,113	ZNF202	ABCA1	7753	19	Gene	Gene	zinc_finger_protein_202|appos|START_ENTITY repressor|nsubj|zinc_finger_protein_202 repressor|nmod|ATP_binding_cassette_transporter_A1 ATP_binding_cassette_transporter_A1|appos|END_ENTITY	The zinc_finger_protein_202 -LRB- ZNF202 -RRB- is a transcriptional repressor of ATP_binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- and ABCG1 gene expression and a modulator of cellular lipid efflux .
12611910	0	ZNF202	0,6	ABCA1	52,57	ZNF202	ABCA1	7753	19	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	ZNF202 is inversely regulated with its target genes ABCA1 and apoE during macrophage differentiation and foam cell formation .
25621839	0	ZNF217	19,25	MiR-203	0,7	ZNF217	MiR-203	7764	406986	Gene	Gene	Upregulation|compound|START_ENTITY Upregulation|compound|END_ENTITY	MiR-203 Suppresses ZNF217 Upregulation in Colorectal_Cancer and Its Oncogenicity .
19741270	0	ZNF224	37,43	PRMT5	84,89	ZNF224	PRMT5	7767	10419	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene .
17126306	0	ZNF237	76,82	presenilin_1	46,58	ZNF237	presenilin 1	9205	5663	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Analysis of transcriptional modulation of the presenilin_1 gene promoter by ZNF237 , a candidate binding partner of the Ets transcription factor ERM .
20510677	0	ZNF24	119,124	platelet-derived_growth_factor_receptor-beta	34,78	ZNF24	platelet-derived growth factor receptor-beta	7572	5159	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	The transcriptional repression of platelet-derived_growth_factor_receptor-beta by the zinc finger transcription factor ZNF24 .
18774934	0	ZNF268	19,25	hUpf1	42,47	ZNF268	hUpf1	10795	5976	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The mammalian gene ZNF268 is regulated by hUpf1 .
18375384	0	ZNF268	61,67	tax	47,50	ZNF268	tax	10795	6900	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Human_T-cell_leukemia_virus_type_1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive_element-binding_protein / activating transcription factor pathway .
21170338	0	ZNF274	0,6	SETDB1	46,52	ZNF274	SETDB1	10782	9869	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	ZNF274 recruits the histone methyltransferase SETDB1 to the 3 ' ends of ZNF genes .
15629158	0	ZNF295	58,64	ZFP161	93,99	ZNF295	ZFP161	49854	7541	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161 .
16542149	0	ZNF297B	24,31	BDP1	47,51	ZNF297B	BDP1	23099	55814	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The zinc finger protein ZNF297B interacts with BDP1 , a subunit of TFIIIB .
20585888	0	ZNF300	0,6	IL-2Rb	78,84	ZNF300	IL-2Rb	91975	3560	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	ZNF300 , a recently identified human transcription factor , activates the human IL-2Rb promoter through the overlapping ZNF300/EGR1 binding site .
19255975	0	ZNF342	169,175	ZNF342	18,24	ZNF342	ZNF342	162979	162979	Gene	Gene	expression|compound|START_ENTITY Overexpression|nmod|expression Overexpression|nmod|END_ENTITY	Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t -LRB- 17 ; 19 -RRB- -LRB- q23 ; q13 .32 -RRB- in pediatric acute myeloid_leukemia and analysis of ZNF342 expression in leukemia .
19255975	0	ZNF342	18,24	ZNF342	169,175	ZNF342	ZNF342	162979	162979	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|expression expression|compound|END_ENTITY	Overexpression of ZNF342 by juxtaposition with MPO promoter/enhancer in the novel translocation t -LRB- 17 ; 19 -RRB- -LRB- q23 ; q13 .32 -RRB- in pediatric acute myeloid_leukemia and analysis of ZNF342 expression in leukemia .
24907849	0	ZNF407	30,36	zinc_finger_407	13,28	ZNF407	zinc finger 407	55628	55628	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	Mutations in zinc_finger_407 -LSB- ZNF407 -RSB- cause a unique autosomal_recessive_cognitive_impairment_syndrome .
23764426	0	ZNF423	72,78	BRCA1	93,98	ZNF423	BRCA1	23090	672	Gene	Gene	regulation|nummod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Selective estrogen receptor modulators and pharmacogenomic variation in ZNF423 regulation of BRCA1 expression : individualized breast_cancer prevention .
21177534	0	ZNF431	64,70	Patched1	90,98	ZNF431	Patched1	170959	5727	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription .
16368201	0	ZNF445	87,93	AP1	44,47	ZNF445	AP1	353274	3725	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of transcriptional activities of AP1 and SRE by a novel zinc finger protein ZNF445 .
15526281	0	ZNF450	91,97	Bone_morphogenetic_protein-2	0,28	ZNF450	Bone morphogenetic protein-2	268294(Tax:10090)	12156(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 induces expression of murine zinc finger transcription factor ZNF450 .
21599657	0	ZNF580	0,6	Smad2	96,101	ZNF580	Smad2	51157	4087	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ZNF580 , a novel C2H2 zinc-finger transcription factor , interacts with the TGF-b signal molecule Smad2 .
26738774	0	ZNF589	35,41	stem_cell_zinc_finger_1	4,27	ZNF589	stem cell zinc finger 1	51385	51385	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The stem_cell_zinc_finger_1 -LRB- SZF1 -RRB- / ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system .
16966434	0	ZNF652	0,6	CBFA2T3	89,96	ZNF652	CBFA2T3	22834	863	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ZNF652 , a novel zinc finger protein , interacts with the putative breast_tumor suppressor CBFA2T3 to repress transcription .
11836360	0	ZNF741	33,39	KLF8	27,31	ZNF741	KLF8	11279	11279	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Abnormal expression of the KLF8 -LRB- ZNF741 -RRB- gene in a female patient with an X ; autosome translocation t -LRB- X ; 21 -RRB- -LRB- p11 .2 ; q22 .3 -RRB- and non-syndromic_mental_retardation .
21376232	0	ZNF746	7,13	PGC-1a	29,35	ZNF746	PGC-1a	155061	10891	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	PARIS -LRB- ZNF746 -RRB- repression of PGC-1a contributes to neurodegeneration in Parkinson 's _ disease .
22364861	0	ZNF750	0,6	KLF4	41,45	ZNF750	KLF4	79755	9314	Gene	Gene	gene|nsubj|START_ENTITY gene|acl:relcl|induces induces|dobj|END_ENTITY	ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation .
25228645	0	ZNF750	0,6	KLF4	22,26	ZNF750	KLF4	79755	9314	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ZNF750 interacts with KLF4 and RCOR1 , KDM1A , and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes .
22425527	0	ZNF804A	24,31	zinc_finger_protein_804A	33,57	ZNF804A	zinc finger protein 804A	91752	91752	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Association analysis of ZNF804A -LRB- zinc_finger_protein_804A -RRB- rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia .
22384243	0	ZNF804a	0,7	PRSS16	67,73	ZNF804a	PRSS16	295695(Tax:10116)	364719(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	ZNF804a regulates expression of the schizophrenia-associated genes PRSS16 , COMT , PDE4B , and DRD2 .
21204798	0	ZNF9	121,125	CNBP	115,119	ZNF9	CNBP	7555	7555	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Myotonia_congenita and myotonic_dystrophy in the same family : coexistence of a CLCN1 mutation and expansion in the CNBP -LRB- ZNF9 -RRB- gene .
16624843	0	ZNF9	96,100	DM2	0,3	ZNF9	DM2	10793	7555	Gene	Gene	processing|amod|START_ENTITY sequence|nmod|processing CCUG|nmod|sequence evidence|acl|CCUG expansions|dep|evidence expansions|nummod|END_ENTITY	DM2 intronic expansions : evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression .
20102514	0	ZNF9	72,76	DM2	31,34	ZNF9	DM2	10793	7555	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The myotonic_dystrophy type 2 -LRB- DM2 -RRB- gene product zinc_finger_protein_9 -LRB- ZNF9 -RRB- is associated with sarcomeres and normally localized in DM2 patients ' muscles .
21080911	0	ZNRD1	8,13	zinc_ribbon_domain-containing_1	15,46	ZNRD1	zinc ribbon domain-containing 1	30834	30834	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of ZNRD1 -LRB- zinc_ribbon_domain-containing_1 -RRB- in angiogenesis of leukaemia cells .
22057101	0	ZNRF1	0,5	AKT	51,54	ZNRF1	AKT	84937	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	ZNRF1 promotes Wallerian_degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation .
19494234	0	ZNT2	20,24	Prolactin	0,9	ZNT2	Prolactin	7780	5617	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells .
9348294	0	ZO-1	35,39	AF-6	15,19	ZO-1	AF-6	292994(Tax:10116)	26955(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells .
16407410	0	ZO-1	65,69	Apg-2	23,28	ZO-1	Apg-2	7082	3308	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB .
25107366	0	ZO-1	20,24	CFTR	0,4	ZO-1	CFTR	21872(Tax:10090)	12638(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway .
11557048	0	ZO-1	29,33	Connexin45	0,10	ZO-1	Connexin45	403752(Tax:9615)	490936(Tax:9615)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells .
9792678	0	ZO-1	57,61	Cortactin	0,9	ZO-1	Cortactin	41062(Tax:7227)	42491(Tax:7227)	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse .
7542259	0	ZO-1	106,110	Epidermal_growth_factor	0,23	ZO-1	Epidermal growth factor	7082	1950	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells .
10790369	0	ZO-1	27,31	ErbB-2	81,87	ZO-1	ErbB-2	7082	2064	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression .
22782886	0	ZO-1	0,4	Erk	15,18	ZO-1	Erk	21872(Tax:10090)	26413(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	ZO-1 regulates Erk , Smad1/5/8 , Smad2 , and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells .
21240187	0	ZO-1	33,37	MRCKb	38,43	ZO-1	MRCKb	7082	9578	Gene	Gene	complex|compound|START_ENTITY complex|compound|END_ENTITY	Cdc42-dependent formation of the ZO-1 / MRCKb complex at the leading edge controls cell migration .
17666436	0	ZO-1	75,79	Shroom2	0,7	ZO-1	Shroom2	403752(Tax:9615)	491734(Tax:9615)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Shroom2 , a myosin-VIIa - and actin-binding protein , directly interacts with ZO-1 at tight junctions .
16463142	0	ZO-1	17,21	connexin45	80,90	ZO-1	connexin45	7082	10052	Gene	Gene	Association|nmod|START_ENTITY correlates|nsubj|Association correlates|nmod|membrane membrane|acl|partitioning partitioning|nmod|mutants mutants|amod|END_ENTITY	Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants .
14527519	0	ZO-1	126,130	epidermal_growth_factor	143,166	ZO-1	epidermal growth factor	407102(Tax:9913)	521832(Tax:9913)	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Infection of human and bovine epithelial cells with Cryptosporidium andersoni induces apoptosis and disrupts tight junctional ZO-1 : effects of epidermal_growth_factor .
11958524	0	ZO-1	74,78	occludin	41,49	ZO-1	occludin	292994(Tax:10116)	83497(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dep|expression	Diabetes-related changes in rat cerebral occludin and zonula occludens-1 -LRB- ZO-1 -RRB- expression .
12604349	0	ZO-1	70,74	occludin	28,36	ZO-1	occludin	7082	100506658	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1 , ZO-2 , and ZO-3 .
21454477	0	ZO-1	11,15	paracingulin	42,54	ZO-1	paracingulin	7082	84952	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells .
19267955	0	ZO-1	104,108	zonula_occludens_protein-1	76,102	ZO-1	zonula occludens protein-1	396567(Tax:9823)	396567(Tax:9823)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula_occludens_protein-1 -LRB- ZO-1 -RRB- expression in weaning piglets .
18817772	0	ZO-1_and_ZO-2	64,77	ZO-2	23,27	ZO-1 and ZO-2	ZO-2	21872;21873	21873(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Tight junction protein ZO-2 expression and relative function of ZO-1_and_ZO-2 during mouse blastocyst formation .
12064592	0	ZO-1_and_alpha	30,44	Connexin-43	0,11	ZO-1 and alpha	Connexin-43	7082	2697	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Connexin-43 interactions with ZO-1_and_alpha - and beta-tubulin .
9531559	0	ZO-1_and_occludin	93,110	ZO-3	0,4	ZO-1 and occludin	ZO-3	403752;403844	403852(Tax:9615)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ZO-3 , a novel member of the MAGUK protein family found at the tight junction , interacts with ZO-1_and_occludin .
23885123	0	ZO-2	22,26	JAM-A	0,5	ZO-2	JAM-A	21873(Tax:10090)	16456(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	JAM-A associates with ZO-2 , afadin , and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function .
14720506	0	ZO-2	27,31	Jun	48,51	ZO-2	Jun	9414	3725	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	The tight junction protein ZO-2 associates with Jun , Fos and C/EBP transcription factors in epithelial cells .
18817772	0	ZO-2	23,27	ZO-1_and_ZO-2	64,77	ZO-2	ZO-1 and ZO-2	21873(Tax:10090)	21872;21873	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Tight junction protein ZO-2 expression and relative function of ZO-1_and_ZO-2 during mouse blastocyst formation .
15975580	0	ZO-2	22,26	hScrib	0,6	ZO-2	hScrib	9414	23513	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells .
9531559	0	ZO-3	0,4	ZO-1_and_occludin	93,110	ZO-3	ZO-1 and occludin	403852(Tax:9615)	403752;403844	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	ZO-3 , a novel member of the MAGUK protein family found at the tight junction , interacts with ZO-1_and_occludin .
15592429	0	ZONAB	20,25	RalA	0,4	ZONAB	RalA	8531	5898	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity .
10979984	0	ZP1	39,42	ZPB	61,64	ZP1	ZPB	395418(Tax:9031)	395692(Tax:9031)	Gene	Gene	different|nsubj|START_ENTITY different|nmod|END_ENTITY	The major chicken egg envelope protein ZP1 is different from ZPB and is synthesized in the liver .
8984189	0	ZP1	53,56	zona_pellucida_protein_1	27,51	ZP1	zona pellucida protein 1	106509336	106509336	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of recombinant pig zona_pellucida_protein_1 -LRB- ZP1 -RRB- to acrosome-reacted spermatozoa .
9739427	0	ZP2	50,53	zona_pellucida_2	32,48	ZP2	zona pellucida 2	7783	7783	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Immunological identification of zona_pellucida_2 -LRB- ZP2 -RRB- protein in human oocytes .
1875328	0	ZP3	35,38	FA-1	19,23	ZP3	FA-1	7784	2175	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human spermatozoal FA-1 binds with ZP3 of porcine zona pellucida .
24583807	0	ZPAC	17,21	zygote-specific_proteasome_assembly_chaperone	23,68	ZPAC	zygote-specific proteasome assembly chaperone	105418(Tax:10090)	105418(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Possible role of ZPAC , zygote-specific_proteasome_assembly_chaperone , during spermatogenesis in the mouse .
10979984	0	ZPB	61,64	ZP1	39,42	ZPB	ZP1	395692(Tax:9031)	395418(Tax:9031)	Gene	Gene	different|nmod|START_ENTITY different|nsubj|END_ENTITY	The major chicken egg envelope protein ZP1 is different from ZPB and is synthesized in the liver .
21911476	0	ZPBP1	66,71	zona_pellucida_binding_protein_1	32,64	ZPBP1	zona pellucida binding protein 1	11055	11055	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of mutations in the zona_pellucida_binding_protein_1 -LRB- ZPBP1 -RRB- gene with abnormal sperm head morphology in infertile men .
26982741	0	ZPI	83,86	Z-Dependent_Protease_Inhibitor	51,81	ZPI	Z-Dependent Protease Inhibitor	51156	51156	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Single Nucleotide Variant rs2232710 in the Protein Z-Dependent_Protease_Inhibitor -LRB- ZPI , SERPINA10 -RRB- Gene Is Not Associated with Deep_Vein_Thrombosis .
12645566	0	ZPR9	49,53	zinc	63,67	ZPR9	ZPR9	90441	90441	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Enhancement of B-MYB transcriptional activity by ZPR9 , a novel zinc finger protein .
16571679	0	ZW10	47,51	RINT-1	0,6	ZW10	RINT-1	9183	60561	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	RINT-1 regulates the localization and entry of ZW10 to the syntaxin_18 complex .
23954399	0	ZXDC	37,41	CCL2	52,56	ZXDC	CCL2	79364	6347	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nummod|END_ENTITY	The zinc finger transcription factor ZXDC activates CCL2 gene expression by opposing BCL6-mediated repression .
23427270	0	ZYX-1	0,5	zyxin	18,23	ZYX-1	zyxin	174951(Tax:6239)	174951(Tax:6239)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	ZYX-1 , the unique zyxin protein of Caenorhabditis_elegans , is involved in dystrophin-dependent muscle_degeneration .
17178896	0	Zac	54,57	Peroxisome_proliferator-activated_receptor_gamma	0,48	Zac	Peroxisome proliferator-activated receptor gamma	353174	5468	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma is a Zac target gene mediating Zac antiproliferation .
17109628	0	Zac1	101,105	Importin_alpha1	0,15	Zac1	Importin alpha1	5325	3838	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Importin_alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1 .
23630160	0	Zac1	0,4	Socs3	71,76	Zac1	Socs3	5325	9021	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Zac1 regulates astroglial differentiation of neural stem cells through Socs3 .
18644983	0	Zac1	75,79	p21	52,55	Zac1	p21	5325	1026	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Modulation of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by Zac1 through the antagonistic regulators p53 and histone_deacetylase_1 in HeLa Cells .
22001409	0	Zac1	0,4	p21	43,46	Zac1	p21	5325	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Zac1 , an Sp1-like protein , regulates human p21 -LRB- WAF1/Cip1 -RRB- gene expression in HeLa cells .
9878110	0	Zap-70	10,16	CD3zeta	34,41	Zap-70	CD3zeta	22637(Tax:10090)	12503(Tax:10090)	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	Increased Zap-70 association with CD3zeta in CD4 T cells from old mice .
11368773	0	Zap-70	12,18	LAT	44,47	Zap-70	LAT	7535	27040	Gene	Gene	sites|amod|START_ENTITY Mapping|dobj|sites Mapping|nmod|END_ENTITY	Mapping the Zap-70 phosphorylation sites on LAT -LRB- linker for activation of T cells -RRB- required for recruitment and activation of signalling proteins in T cells .
24164480	0	Zap70	99,104	T-cell_receptor	108,123	Zap70	T-cell receptor	22637(Tax:10090)	328483(Tax:10090)	Gene	Gene	START_ENTITY|nmod|signalling signalling|amod|END_ENTITY	A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell_receptor signalling .
22447046	0	Zbtb7	101,106	CDK2	35,39	Zbtb7	CDK2	51341	1017	Gene	Gene	role|nmod|START_ENTITY implications|nmod|role expression|dep|implications expression|nmod|END_ENTITY	Zbtb7 suppresses the expression of CDK2 and E2F4 in liver_cancer cells : implications for the role of Zbtb7 in cell cycle regulation .
19723341	0	Zbtb7A	13,19	SP1	0,3	Zbtb7A	SP1	51341	6667	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	SP1 enhances Zbtb7A gene expression via direct binding to GC box in HePG2 cells .
17878336	0	Zbtb7b	25,31	CD4	41,44	Zbtb7b	CD4	51043	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer .
22132693	0	Zc3h12a	54,61	IL-6	35,39	Zc3h12a	IL-6	80149	3569	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|production production|compound|END_ENTITY	Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells .
19713958	0	Zcchc11	26,33	Lin28	0,5	Zcchc11	Lin28	230594(Tax:10090)	83557(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells .
26114892	0	Zcchc11	47,54	TUTase	55,61	Zcchc11	TUTase	23318	64852	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Identification of small molecule inhibitors of Zcchc11 TUTase activity .
11134339	0	Zds1	98,102	Bcy1	84,88	Zds1	Bcy1	855316(Tax:4932)	854778(Tax:4932)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain .
16157662	0	Zds1	18,22	Pkc1	0,4	Zds1	Pkc1	855316(Tax:4932)	852169(Tax:4932)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Pkc1 acts through Zds1 and Gic1 to suppress growth and cell polarity defects of a yeast eIF5A mutant .
18762578	0	Zds1	25,29	Separase	0,8	Zds1	Separase	855316(Tax:4932)	852990(Tax:4932)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase .
23667256	0	Zeb1	0,4	E-cadherin	15,25	Zeb1	E-cadherin	114425(Tax:7955)	114424(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Zeb1 regulates E-cadherin and Epcam -LRB- epithelial_cell_adhesion_molecule -RRB- expression to control cell behavior in early zebrafish development .
23174018	0	Zeb1	71,75	IL-1b	0,5	Zeb1	IL-1b	6935	3553	Gene	Gene	activation|amod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	IL-1b promotes stemness and invasiveness of colon_cancer cells through Zeb1 activation .
23844063	0	Zeb1	59,63	MicroRNA-23b	0,12	Zeb1	MicroRNA-23b	6935	407011	Gene	Gene	regulating|dobj|START_ENTITY suppressor|advcl|regulating suppressor|nsubj|functions functions|amod|END_ENTITY	MicroRNA-23b functions as a tumor suppressor by regulating Zeb1 in bladder_cancer .
19515996	0	Zeb1	0,4	Mitf	15,19	Zeb1	Mitf	21417(Tax:10090)	17342(Tax:10090)	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	Zeb1 represses Mitf and regulates pigment synthesis , cell proliferation , and epithelial morphology .
25391656	0	Zeb1	73,77	Thioredoxin-interacting_Protein	27,58	Zeb1	Thioredoxin-interacting Protein	6935	10628	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	MicroRNA-200 Is Induced by Thioredoxin-interacting_Protein and Regulates Zeb1 Protein Signaling and Beta Cell Apoptosis .
15845352	0	Zfp-57	18,24	STAT3	53,58	Zfp-57	STAT3	346171	6774	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3 / 4 in embryonic stem cells .
18523156	0	Zfp202	25,31	SOX17	0,5	Zfp202	SOX17	7753	64321	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	SOX17 directly activates Zfp202 transcription during in vitro endoderm differentiation .
25057009	0	Zfp318	0,6	IgD	17,20	Zfp318	IgD	24149	3495	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus .
20951345	0	Zfp521	0,6	parathyroid_hormone-related_peptide	44,79	Zfp521	parathyroid hormone-related peptide	225207(Tax:10090)	19227(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Zfp521 is a target gene and key effector of parathyroid_hormone-related_peptide signaling in growth plate chondrocytes .
25445595	0	Zfp57	27,32	Nanog	0,5	Zfp57	Nanog	22715(Tax:10090)	71950(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nanog positively regulates Zfp57 expression in mouse embryonic_stem cells .
23954693	0	Zfp819	0,6	KAP1	57,61	Zfp819	KAP1	74400(Tax:10090)	21849(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Zfp819 , a novel KRAB-zinc_finger_protein , interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells .
25686832	0	Zfra	0,4	Hyal-2	22,28	Zfra	Hyal-2	11787(Tax:10090)	15587(Tax:10090)	Gene	Gene	CD3|compound|START_ENTITY CD3|compound|END_ENTITY	Zfra activates memory Hyal-2 + CD3 - CD19 - spleen cells to block cancer growth , stemness , and metastasis in vivo .
15705566	0	Zhangfei	0,8	Luman	97,102	Zhangfei	Luman	58487	10488	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Zhangfei is a potent and specific inhibitor of the host cell factor-binding transcription factor Luman .
18719857	0	Zhangfei	0,8	nerve_growth_factor_receptor	39,67	Zhangfei	nerve growth factor receptor	58487	4804	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Zhangfei induces the expression of the nerve_growth_factor_receptor , trkA , in medulloblastoma cells and causes their differentiation or apoptosis .
19016376	0	Zhangfei	0,8	nerve_growth_factor_receptor	41,69	Zhangfei	nerve growth factor receptor	58487	4804	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Zhangfei , a novel regulator of the human nerve_growth_factor_receptor , trkA .
8436277	2	Zhr	101,104	Zygotic_hybrid_rescue	78,99	Zhr	Zygotic hybrid rescue	44888	44888	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Zygotic_hybrid_rescue -LRB- Zhr -RRB- gene of D. _ melanogaster .
21211521	0	Zic1	11,15	Myf5	28,32	Zic1	Myf5	22771(Tax:10090)	17877(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|amod|END_ENTITY	A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis .
11756505	0	Zic1	57,61	Zic2	0,4	Zic1	Zic2	22771(Tax:10090)	22772(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Zic2 controls cerebellar development in cooperation with Zic1 .
20676059	0	Zic2	0,4	Sert	33,37	Zic2	Sert	7546	6532	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets .
11756505	0	Zic2	0,4	Zic1	57,61	Zic2	Zic1	22772(Tax:10090)	22771(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Zic2 controls cerebellar development in cooperation with Zic1 .
23275352	0	Zinc-a2-glycoprotein	0,20	insulin	40,47	Zinc-a2-glycoprotein	insulin	563	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Zinc-a2-glycoprotein is associated with insulin resistance in humans and is regulated by hyperglycemia , hyperinsulinemia , or liraglutide administration : cross-sectional and interventional studies in normal subjects , insulin-resistant subjects , and subjects with newly diagnosed diabetes .
26097576	0	Zinc-finger_protein_X-linked	19,47	E-cadherin	75,85	Zinc-finger protein X-linked	E-cadherin	7543	999	Gene	Gene	expression|nmod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|amod|END_ENTITY	High expression of Zinc-finger_protein_X-linked is associated with reduced E-cadherin expression and unfavorable prognosis in nasopharyngeal_carcinoma .
25921144	0	Zinc_Transporters	31,48	ZIP4	50,54	Zinc Transporters	ZIP4	10463	55630	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Expression Profile Analysis of Zinc_Transporters -LRB- ZIP4 , ZIP9 , ZIP11 , ZnT9 -RRB- in Gliomas and their Correlation with IDH1 Mutation Status .
22095522	0	Zinc_finger_E-box_Binding_homeobox_1	25,61	ZEB1	63,67	Zinc finger E-box Binding homeobox 1	ZEB1	6935	6935	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of Zinc_finger_E-box_Binding_homeobox_1 -LRB- ZEB1 -RRB- in human gastric_cancer .
23777805	0	Zinc_finger_protein_668	0,23	Tip60	39,44	Zinc finger protein 668	Tip60	79759	10524	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Zinc_finger_protein_668 interacts with Tip60 to promote H2AX acetylation after DNA damage .
18628523	0	Zinc_transporter-8	0,18	SLC30A8	25,32	Zinc transporter-8	SLC30A8	55532	169026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Zinc_transporter-8 gene -LRB- SLC30A8 -RRB- is associated with type 2 diabetes in Chinese .
23209723	0	Zinc_transporter_8	0,18	ZnT8	20,24	Zinc transporter 8	ZnT8	239436(Tax:10090)	239436(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Zinc_transporter_8 -LRB- ZnT8 -RRB- expression is reduced by ischemic insults : a potential therapeutic target to prevent ischemic_retinopathy .
19179618	0	Zip14	115,120	Interleukin-1beta	0,17	Zip14	Interleukin-1beta	213053(Tax:10090)	16176(Tax:10090)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Interleukin-1beta contributes via nitric_oxide to the upregulation and functional activity of the zinc transporter Zip14 -LRB- Slc39a14 -RRB- in murine hepatocytes .
15863613	0	Zip14	45,50	Interleukin-6	0,13	Zip14	Interleukin-6	213053(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response .
23686108	0	Zip2	25,29	Slc39A2	17,24	Zip2	Slc39A2	29986	29986	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Up-regulation of Slc39A2 -LRB- Zip2 -RRB- mRNA in peripheral blood mononuclear cells from patients with pulmonary_tuberculosis .
17506078	0	Zip2	32,36	Slc39a2	23,30	Zip2	Slc39a2	214922(Tax:10090)	214922(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Targeting of the mouse Slc39a2 -LRB- Zip2 -RRB- gene reveals highly cell-specific patterns of expression , and unique functions in zinc , iron , and calcium homeostasis .
20957146	0	Zip4	0,4	Slc39a4	6,13	Zip4	Slc39a4	55630	55630	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Zip4 -LRB- Slc39a4 -RRB- expression is activated in hepatocellular_carcinomas and functions to repress apoptosis , enhance cell cycle and increase migration .
25831050	0	Zipper-interacting_protein_kinase	0,33	AKT	110,113	Zipper-interacting protein kinase	AKT	1613	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|signaling signaling|compound|END_ENTITY	Zipper-interacting_protein_kinase promotes epithelial-mesenchymal transition , invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric_cancer patients .
12617811	0	Ziwi	0,4	piwi	48,52	Ziwi	piwi	368200(Tax:7955)	34521(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Ziwi , the zebrafish homologue of the Drosophila piwi : co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults .
14516689	0	Ziwi	0,4	piwi	48,52	Ziwi	piwi	368200(Tax:7955)	34521(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Ziwi , the zebrafish homologue of the Drosophila piwi : co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults .
12172552	0	Zizimin1	0,8	Cdc42	18,23	Zizimin1	Cdc42	23348	998	Gene	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Zizimin1 , a novel Cdc42 activator , reveals a new GEF domain for Rho proteins .
7846159	0	Zlp	72,75	zeamatin-like_protein	49,70	Zlp	zeamatin-like protein	542299(Tax:4577)	542299(Tax:4577)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization and expression of an antifungal zeamatin-like_protein -LRB- Zlp -RRB- gene from Zea_mays .
15347785	0	ZmHy2	10,15	Elm1	4,8	ZmHy2	Elm1	542164(Tax:4577)	542164(Tax:4577)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Elm1 -LRB- ZmHy2 -RRB- gene of maize encodes a phytochromobilin_synthase .
15257762	0	ZmPox3	28,34	peroxidase	41,51	ZmPox3	peroxidase	542505(Tax:4577)	542029(Tax:4577)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Nucleotide diversity of the ZmPox3 maize peroxidase gene : relationships between a MITE insertion in exon 2 and variation in forage maize digestibility .
26522984	0	Zmiz1	26,31	Notch1	70,76	Zmiz1	Notch1	57178	4851	Gene	Gene	Cofactor|nsubj|START_ENTITY Cofactor|nmod|END_ENTITY	The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia .
21095585	0	ZnF4	25,29	A20	21,24	ZnF4	A20	7897	7128	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kB signaling .
24194756	0	ZnT-2	98,103	SLC30A2	105,112	ZnT-2	SLC30A2	7780	7780	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Transient Neonatal_Zinc_Deficiency Caused by a Heterozygous G87R Mutation in the Zinc Transporter ZnT-2 -LRB- SLC30A2 -RRB- Gene in the Mother Highlighting the Importance of Zn _ -LRB- 2 + -RRB- for Normal Growth and Development .
25808614	0	ZnT2	34,38	TNFa	0,4	ZnT2	TNFa	7780	7124	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	TNFa post-translationally targets ZnT2 to accumulate zinc in lysosomes .
14657250	0	ZnT3	21,25	AP-3	41,45	ZnT3	AP-3	22784(Tax:10090)	11774(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation .
26720469	0	ZnT8	76,80	ERK	96,99	ZnT8	ERK	299903(Tax:10116)	24338(Tax:10116)	Gene	Gene	START_ENTITY|nmod|Pathway Pathway|compound|END_ENTITY	Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1a Expression .
19479076	0	ZnT8	19,23	INS-1	38,43	ZnT8	INS-1	299903(Tax:10116)	24505(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion .
23209723	0	ZnT8	20,24	Zinc_transporter_8	0,18	ZnT8	Zinc transporter 8	239436(Tax:10090)	239436(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Zinc_transporter_8 -LRB- ZnT8 -RRB- expression is reduced by ischemic insults : a potential therapeutic target to prevent ischemic_retinopathy .
16984975	0	ZnT8	75,79	insulin	99,106	ZnT8	insulin	169026	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion .
2503265	0	Zn_alpha_2-glycoprotein	33,56	alpha_2HS-glycoprotein	73,95	Zn alpha 2-glycoprotein	alpha 2HS-glycoprotein	563	197	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Unusually high concentrations of Zn_alpha_2-glycoprotein and the lack of alpha_2HS-glycoprotein in human ejaculates .
19056685	0	Zona_occludens-2	0,16	cyclin_D1	26,35	Zona occludens-2	cyclin D1	9414	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Zona_occludens-2 inhibits cyclin_D1 expression and cell proliferation and exhibits changes in localization along the cell cycle .
24840609	0	Zscan4	0,6	Rap1	37,41	Zscan4	Rap1	201516	54386	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status .
25772165	0	Zscan4c	33,40	Nr0b1	0,5	Zscan4c	Nr0b1	245109(Tax:10090)	11614(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells .
16732327	0	Zwint-1	27,34	Hec1	0,4	Zwint-1	Hec1	11130	10403	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control .
8436277	2	Zygotic_hybrid_rescue	78,99	Zhr	101,104	Zygotic hybrid rescue	Zhr	44888	44888	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Zygotic_hybrid_rescue -LRB- Zhr -RRB- gene of D. _ melanogaster .
25450971	0	Zyxin	57,62	BCR-ABL	66,73	Zyxin	BCR-ABL	7791	25	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells .
25728696	0	Zyxin	0,5	F-Actin	54,61	Zyxin	F-Actin	317824(Tax:7227)	40444(Tax:7227)	Gene	Gene	Antagonizes|nsubj|START_ENTITY Antagonizes|nmod|END_ENTITY	Zyxin Antagonizes the FERM Protein Expanded to Couple F-Actin and Yorkie-Dependent Organ Growth .
23321499	0	Zyxin	0,5	PTOV1	22,27	Zyxin	PTOV1	7791	53635	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Zyxin cooperates with PTOV1 to confer retinoic_acid resistance by repressing RAR activity .
23685334	0	Zyxin	25,30	Shh	40,43	Zyxin	Shh	100049724(Tax:8355)	398047(Tax:8355)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The cytoskeletal protein Zyxin inhibits Shh signaling during the CNS patterning in Xenopus_laevis through interaction with the transcription factor Gli1 .
22778267	0	Zyxin	0,5	Smad3	48,53	Zyxin	Smad3	22793(Tax:10090)	17127(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
23657850	0	Zyxin	0,5	hepatocyte_nuclear_factor-1b	74,102	Zyxin	hepatocyte nuclear factor-1b	7791	6928	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|activation activation|nmod|END_ENTITY	Zyxin regulates migration of renal epithelial cells through activation of hepatocyte_nuclear_factor-1b .
11598195	0	Zyxin	0,5	vasodilator-stimulated_phosphoprotein	30,67	Zyxin	vasodilator-stimulated phosphoprotein	7791	7408	Gene	Gene	colocalized|nsubjpass|START_ENTITY colocalized|nmod|END_ENTITY	Zyxin is not colocalized with vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- at lamellipodial tips and exhibits different dynamics to vinculin , paxillin , and VASP in focal adhesions .
26276722	0	a-3p	83,87	miR-133b	74,82	a-3p	miR-133b	10312	442890	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	Identification of miRNomes in human stomach and gastric_carcinoma reveals miR-133b / a-3p as therapeutic target for gastric_cancer .
26912655	0	a-SMA	16,21	SIRT3	0,5	a-SMA	SIRT3	11475(Tax:10090)	64384(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	SIRT3 regulates a-SMA production through the succinate_dehydrogenase-GPR91 pathway in hepatic stellate cells .
21459437	0	a-SMA	36,41	bFGF	12,16	a-SMA	bFGF	58	2247	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	The role of bFGF in down-regulating a-SMA expression of chondrogenically induced BMSCs and preventing the shrinkage of BMSC engineered cartilage .
24375477	0	a-actinin-4	111,122	Small_leucine_zipper_protein	0,28	a-actinin-4	Small leucine zipper protein	81	10488	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Small_leucine_zipper_protein -LRB- sLZIP -RRB- negatively regulates skeletal muscle differentiation via interaction with a-actinin-4 .
21654638	0	a-fetoprotein	34,47	MicroRNA122	0,11	a-fetoprotein	MicroRNA122	174	406906	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	MicroRNA122 is a key regulator of a-fetoprotein expression and influences the aggressiveness of hepatocellular_carcinoma .
26888362	0	a-methylacyl-CoA_racemase	0,25	AMACR	27,32	a-methylacyl-CoA racemase	AMACR	23600	23600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	a-methylacyl-CoA_racemase -LRB- AMACR -RRB- expression in chordomas differentiates them from chondrosarcomas .
23797726	0	a-methylacyl-CoA_racemase	98,123	ERG	128,131	a-methylacyl-CoA racemase	ERG	23600	2078	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Foamy gland carcinoma_of_the_prostate in needle biopsy : incidence , Gleason grade , and comparative a-methylacyl-CoA_racemase vs. ERG expression .
22829926	0	a-smooth_muscle_actin	53,74	PIASy	37,42	a-smooth muscle actin	PIASy	58	51588	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Protein inhibitor of activated STAT , PIASy regulates a-smooth_muscle_actin expression by interacting with E12 in mesangial cells .
26481780	0	a-smooth_muscle_actin	36,57	PPAR	119,123	a-smooth muscle actin	PPAR	58	5465	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Ligand-activated PPAR upregulates a-smooth_muscle_actin expression in human dermal fibroblasts : A potential role for PPAR in wound healing .
26481780	0	a-smooth_muscle_actin	36,57	PPAR	17,21	a-smooth muscle actin	PPAR	58	5465	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Ligand-activated PPAR upregulates a-smooth_muscle_actin expression in human dermal fibroblasts : A potential role for PPAR in wound healing .
24068189	0	a-smooth_muscle_actin	81,102	retinoblastoma_binding_protein_2	20,52	a-smooth muscle actin	retinoblastoma binding protein 2	58	5927	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Histone demethylase retinoblastoma_binding_protein_2 regulates the expression of a-smooth_muscle_actin and vimentin in cirrhotic livers .
23751361	0	a-synuclein	205,216	E6-AP	176,181	a-synuclein	E6-AP	6622	7337	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Reynosin protects against neuronal_toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson 's _ disease : Reciprocal up-regulation of E6-AP and down-regulation of a-synuclein .
21272100	0	a-synuclein	52,63	a-synuclein	86,97	a-synuclein	a-synuclein	6622	6622	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Biochemical and morphological consequences of human a-synuclein expression in a mouse a-synuclein null background .
21272100	0	a-synuclein	86,97	a-synuclein	52,63	a-synuclein	a-synuclein	6622	6622	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Biochemical and morphological consequences of human a-synuclein expression in a mouse a-synuclein null background .
24412932	0	a-synuclein	21,32	c-Abl	0,5	a-synuclein	c-Abl	6622	25	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Abl phosphorylates a-synuclein and regulates its degradation : implication for a-synuclein clearance and contribution to the pathogenesis of Parkinson 's _ disease .
26346361	0	a-synuclein	10,21	toll-like_receptor_4	30,50	a-synuclein	toll-like receptor 4	6622	7099	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|responses responses|amod|END_ENTITY	Exogenous a-synuclein induces toll-like_receptor_4 dependent inflammatory responses in astrocytes .
26346361	0	a-synuclein	10,21	toll-like_receptor_4	30,50	a-synuclein	toll-like receptor 4	6622	7099	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|responses responses|amod|END_ENTITY	Exogenous a-synuclein induces toll-like_receptor_4 dependent inflammatory responses in astrocytes .
25341065	0	a1-Antitrypsin	0,14	phosphatase_2A	33,47	a1-Antitrypsin	phosphatase 2A	5265	5524	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	a1-Antitrypsin activates protein phosphatase_2A to counter lung inflammatory responses .
25516596	0	a1B	47,50	14-3-3	0,6	a1B	14-3-3	1	10971	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	14-3-3 Promotes Surface Expression of Cav2 .2 -LRB- a1B -RRB- Ca2 + Channels .
23397525	0	a2-macroglobulin	65,81	insulin-like_growth_factor-binding_protein_2	15,59	a2-macroglobulin	insulin-like growth factor-binding protein 2	2	3485	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of insulin-like_growth_factor-binding_protein_2 with a2-macroglobulin in the circulation .
25190567	0	a20	20,23	Adiponectin	0,11	a20	Adiponectin	7128	9370	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Adiponectin induces a20 expression in adipose tissue to confer metabolic benefit .
21979958	0	a7_nicotinic_acetylcholine_receptor	34,69	AP-2a	118,123	a7 nicotinic acetylcholine receptor	AP-2a	1139	7020	Gene	Gene	gene|amod|START_ENTITY repression|nmod|gene repression|nmod|END_ENTITY	Transcriptional repression of the a7_nicotinic_acetylcholine_receptor subunit gene -LRB- CHRNA7 -RRB- by activating protein-2a -LRB- AP-2a -RRB- .
17460766	0	aFGF	20,24	FGF1	14,18	aFGF	FGF1	25317(Tax:10116)	25317(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Comparison of FGF1 -LRB- aFGF -RRB- expression between the dorsal motor nucleus of vagus and the hypoglossal nucleus of rat .
12044971	0	aFGF	30,34	IL6	11,14	aFGF	IL6	2246	3569	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of IL6 and IL1beta on aFGF expression and excitotoxicity in NT2N cells .
7686384	0	aFGF	0,4	aFGF	61,65	aFGF	aFGF	281160(Tax:9913)	281160(Tax:9913)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	aFGF binding to low and high affinity receptors induces both aFGF and aFGF receptors dimerization .
7686384	0	aFGF	61,65	aFGF	0,4	aFGF	aFGF	281160(Tax:9913)	281160(Tax:9913)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	aFGF binding to low and high affinity receptors induces both aFGF and aFGF receptors dimerization .
1701865	0	aFGF	49,53	acidic_fibroblast_growth_factor	16,47	aFGF	acidic fibroblast growth factor	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of acidic_fibroblast_growth_factor -LRB- aFGF -RRB- mRNA in mouse and bovine retina by in situ hybridization .
7507349	0	aFGF	61,65	acidic_fibroblast_growth_factor	28,59	aFGF	acidic fibroblast growth factor	281160(Tax:9913)	281160(Tax:9913)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Developmental regulation of acidic_fibroblast_growth_factor -LRB- aFGF -RRB- expression in bovine retina .
7680120	0	aFGF	69,73	acidic_fibroblast_growth_factor	36,67	aFGF	acidic fibroblast growth factor	2246	2246	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Cloning of two novel forms of human acidic_fibroblast_growth_factor -LRB- aFGF -RRB- mRNA .
9572047	0	aFGF	43,47	acidic_fibroblast_growth_factor	10,41	aFGF	acidic fibroblast growth factor	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of acidic_fibroblast_growth_factor -LRB- aFGF -RRB- on phagocytosis in mouse peritoneal macrophages .
8764646	0	aFGF	109,113	fibroblast_growth_factor_receptor-1	4,39	aFGF	fibroblast growth factor receptor-1	25317(Tax:10116)	79114(Tax:10116)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	The fibroblast_growth_factor_receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF .
1324471	0	aI3	32,35	COX1	43,47	aI3	COX1	854595(Tax:4932)	854598(Tax:4932)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Splice site selection by intron aI3 of the COX1 gene from Saccharomyces_cerevisiae .
18324929	0	aP2	51,54	RBP4	27,31	aP2	RBP4	2167	5950	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	High circulating levels of RBP4 and mRNA levels of aP2 , PGC-1alpha and UCP-2 predict improvement_in_insulin_sensitivity following pioglitazone treatment of drug-na ve type 2 diabetic subjects .
26751773	0	aP2	43,46	prohibitin	23,33	aP2	prohibitin	21418(Tax:10090)	18673(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Expression of a mutant prohibitin from the aP2 gene promoter leads to obesity-linked_tumor development in insulin resistance-dependent manner .
11784294	0	aP2	48,51	uncoupling_protein_1	18,38	aP2	uncoupling protein 1	21418(Tax:10090)	22227(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Expression of the uncoupling_protein_1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo .
17726059	0	aPKC	79,83	Bazooka	25,32	aPKC	Bazooka	47594(Tax:7227)	32703(Tax:7227)	Gene	Gene	regulate|nmod|START_ENTITY acts|xcomp|regulate acts|dobj|downstream downstream|nmod|END_ENTITY	Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC .
20434988	0	aPKC	0,4	Bazooka	24,31	aPKC	Bazooka	47594(Tax:7227)	32703(Tax:7227)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	aPKC phosphorylation of Bazooka defines the apical/lateral _ border in Drosophila epithelial cells .
24173807	0	aPKC	17,21	Bazooka	0,7	aPKC	Bazooka	47594(Tax:7227)	32703(Tax:7227)	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Bazooka inhibits aPKC to limit antagonism of actomyosin networks during amnioserosa apical constriction .
8345467	0	aSFP	80,84	acetic_seminal_fluid_protein	50,78	aSFP	acetic seminal fluid protein	282373(Tax:9913)	282373(Tax:9913)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and concentration of a new bioactive acetic_seminal_fluid_protein -LRB- aSFP -RRB- in bulls -LRB- Bos_taurus -RRB- .
7945995	0	aSFP	69,73	acidic_seminal_fluid_protein	39,67	aSFP	acidic seminal fluid protein	282373(Tax:9913)	282373(Tax:9913)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization and quantitation of acidic_seminal_fluid_protein -LRB- aSFP -RRB- in ejaculated , swim-up , and capacitated bull spermatozoa .
26348210	0	a_Proliferation-Inducing_Ligand	19,50	APRIL	52,57	a Proliferation-Inducing Ligand	APRIL	69583(Tax:10090)	69583(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Pathogenic Role of a_Proliferation-Inducing_Ligand -LRB- APRIL -RRB- in Murine IgA Nephropathy .
26348210	0	a_Proliferation-Inducing_Ligand	19,50	APRIL	52,57	a Proliferation-Inducing Ligand	APRIL	69583(Tax:10090)	69583(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Pathogenic Role of a_Proliferation-Inducing_Ligand -LRB- APRIL -RRB- in Murine IgA Nephropathy .
10072448	0	a_beta	66,72	C10	83,86	a beta	C10	351	3226	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Presence of P210bcrabl is associated with decreased expression of a_beta chemokine C10 gene in a P210bcrabl-positive myeloid_leukemia cell line .
14564349	0	a_disintegrin_and_metalloprotease_33	15,51	ADAM33	53,59	a disintegrin and metalloprotease 33	ADAM33	80332	80332	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a_disintegrin_and_metalloprotease_33 -LRB- ADAM33 -RRB- gene with asthma in ethnically diverse populations .
1358590	0	abd-A	45,50	bithorax_complex	65,81	abd-A	bithorax complex	42037(Tax:7227)	42034(Tax:7227)	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Gonad formation and development requires the abd-A domain of the bithorax_complex in Drosophila_melanogaster .
1352698	0	abdominal-A	78,89	bithorax_complex	104,120	abdominal-A	bithorax complex	42037(Tax:7227)	42034(Tax:7227)	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Segmental_determination in Drosophila central nervous system : analysis of the abdominal-A region of the bithorax_complex .
16361522	0	abh1	118,122	AtPP2CA	126,133	abh1	AtPP2CA	815840(Tax:3702)	820314(Tax:3702)	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	The protein phosphatase AtPP2CA negatively regulates abscisic_acid signal transduction in Arabidopsis , and effects of abh1 on AtPP2CA mRNA .
26574024	0	abhydrolase_domain_containing_5	11,42	ABHD5	49,54	abhydrolase domain containing 5	ABHD5	420673(Tax:9031)	420673(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of abhydrolase_domain_containing_5 gene -LRB- ABHD5 -RRB- expression and variations on chicken fat metabolism .
9798684	0	abl	15,18	IL-7	32,36	abl	IL-7	11350(Tax:10090)	16196(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of abl and raf with IL-7 signaling pathway and transformation of pre-B cells from resistant mice .
23530044	0	absent_in_melanoma_2	17,37	AIM2	39,43	absent in melanoma 2	AIM2	9447	9447	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Structure of the absent_in_melanoma_2 -LRB- AIM2 -RRB- pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly .
15494558	0	accumulation	83,95	ACCUMULATION_OF_PHOTOSYSTEM_ONE1	0,32	accumulation	ACCUMULATION OF PHOTOSYSTEM ONE1	842789(Tax:3702)	842789(Tax:3702)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	ACCUMULATION_OF_PHOTOSYSTEM_ONE1 , a member of a novel gene family , is required for accumulation of -LSB- 4Fe-4S -RSB- cluster-containing chloroplast complexes and antenna proteins .
24323194	0	ace1	98,102	acetylcholinesterase_type_1	64,91	ace1	acetylcholinesterase type 1	692783(Tax:7091)	692783(Tax:7091)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional study on the mutations in the silkworm -LRB- Bombyx_mori -RRB- acetylcholinesterase_type_1 gene -LRB- ace1 -RRB- and its recombinant proteins .
8345467	0	acetic_seminal_fluid_protein	50,78	aSFP	80,84	acetic seminal fluid protein	aSFP	282373(Tax:9913)	282373(Tax:9913)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and concentration of a new bioactive acetic_seminal_fluid_protein -LRB- aSFP -RRB- in bulls -LRB- Bos_taurus -RRB- .
20102333	0	acetoacetyl-CoA_synthetase	40,66	PPARgamma	75,84	acetoacetyl-CoA synthetase	PPARgamma	65985	5468	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the human acetoacetyl-CoA_synthetase gene by PPARgamma .
12754704	0	acetoacetyl-CoA_thiolase	70,94	ACAT1/T2	96,104	acetoacetyl-CoA thiolase	ACAT1/T2	38	38	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single base substitutions at the initiator codon in the mitochondrial acetoacetyl-CoA_thiolase -LRB- ACAT1/T2 -RRB- gene result in production of varying amounts of wild-type T2 polypeptide .
21838297	0	acetohydroxyacid_synthase	29,54	AHAS	56,60	acetohydroxyacid synthase	AHAS	824015(Tax:3702)	824015(Tax:3702)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Chemical synthesis , in vitro acetohydroxyacid_synthase -LRB- AHAS -RRB- inhibition , herbicidal activity , and computational studies of isatin derivatives .
10212805	0	acetylcholinesterase	32,52	AChE	54,58	acetylcholinesterase	AChE	396388(Tax:9031)	396388(Tax:9031)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Ultrastructural localization of acetylcholinesterase -LRB- AChE -RRB- activity in the chicken Harderian gland .
115211	0	acetylcholinesterase	37,57	AChE	59,63	acetylcholinesterase	AChE	83817(Tax:10116)	83817(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Ultrastructural localization of the acetylcholinesterase -LRB- AChE -RRB- activity in the diaphragm of the rat embryo -LRB- author 's transl -RRB- -RSB- .
17158047	0	acetylcholinesterase	83,103	AChE	105,109	acetylcholinesterase	AChE	43	43	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Quantitative structure-activity relationship -LRB- QSAR -RRB- of tacrine derivatives against acetylcholinesterase -LRB- AChE -RRB- activity using variable selections .
17765967	0	acetylcholinesterase	26,46	AChE	48,52	acetylcholinesterase	AChE	43	43	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of azadirachtin on acetylcholinesterase -LRB- AChE -RRB- activity and histology of the brown_planthopper_Nilaparvata lugens -LRB- St l -RRB- .
2013059	0	acetylcholinesterase	27,47	AChE	49,53	acetylcholinesterase	AChE	43	43	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	A noncholinergic action of acetylcholinesterase -LRB- AChE -RRB- in the brain : from neuronal secretion to the generation of movement .
23863115	0	acetylcholinesterase	97,117	AChE	119,123	acetylcholinesterase	AChE	43	43	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Molecular dynamics simulation study and molecular docking descriptors in structure-based QSAR on acetylcholinesterase -LRB- AChE -RRB- inhibitors .
24589276	0	acetylcholinesterase	10,30	AChE	32,36	acetylcholinesterase	AChE	43	43	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of acetylcholinesterase -LRB- AChE -RRB- point-of-care testing in OP poisoning on knowledge , attitudes and practices of treating physicians in Sri Lanka .
25450939	0	acetylcholinesterase	22,42	AChE	44,48	acetylcholinesterase	AChE	43	43	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Circannual rhythms of acetylcholinesterase -LRB- AChE -RRB- activity in the freshwater fish Cnesterodon decemmaculatus .
3216102	0	acetylcholinesterase	28,48	AChE	50,54	acetylcholinesterase	AChE	100009390(Tax:9986)	100009390(Tax:9986)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Morphological changes after acetylcholinesterase -LRB- AChE -RRB- inhibition by dichlorvos -LRB- DDVP -RRB- in young rabbit brain .
8052513	0	acetylcholinesterase	49,69	AChE	71,75	acetylcholinesterase	AChE	101123006	101123006	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Purification and biochemical characterization of acetylcholinesterase -LRB- AChE -RRB- from the excretory/secretory products of Trichostrongylus colubriformis .
8545050	0	acetylcholinesterase	23,43	AChE	45,49	acetylcholinesterase	AChE	43	43	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inverse correlation of acetylcholinesterase -LRB- AChE -RRB- activity with the presence of neurofilament inclusions in dorsal root ganglion neurons cultured in the presence of a reversible inhibitor of AChE .
8994044	0	acetylcholinesterase	8,28	AChE	30,34	acetylcholinesterase	AChE	11423(Tax:10090)	11423(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Reduced acetylcholinesterase -LRB- AChE -RRB- activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient , but not TrkB-deficient , mice .
9500847	0	acetylcholinesterase	39,59	AChE	61,65	acetylcholinesterase	AChE	43	43	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Elucidation of biphasic alterations on acetylcholinesterase -LRB- AChE -RRB- activity and membrane fluidity in the structure-functional effects of tetracaine on AChE-associated membrane vesicles .
20501103	0	acetylcholinesterase	118,138	Acetylcholinesterase	0,20	acetylcholinesterase	Acetylcholinesterase	100009390(Tax:9986)	100009390(Tax:9986)	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|dep|presence	Acetylcholinesterase in membrane fractions derived from sarcotubular system of skeletal muscle : presence of monomeric acetylcholinesterase in sarcoplasmic reticulum and transverse tubule membranes .
19185568	0	acetylcholinesterase	11,31	AchE	33,37	acetylcholinesterase	AchE	43	43	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Changes in acetylcholinesterase -LRB- AchE -RRB- activity in lymphocytes and whole blood in acute_lymphoblastic_leukemia patients .
24028855	0	acetylcholinesterase	38,58	AchE	60,64	acetylcholinesterase	AchE	43	43	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Effect of pharmaceuticals exposure on acetylcholinesterase -LRB- AchE -RRB- activity and on the expression of AchE gene in the monogonont rotifer , Brachionus koreanus .
16257398	0	acetylcholinesterase	14,34	CPT-11	61,67	acetylcholinesterase	CPT-11	43	963084(Tax:115711)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11 .
8783275	0	acetylcholinesterase	43,63	Ciliary_neurotrophic_factor	0,27	acetylcholinesterase	Ciliary neurotrophic factor	83817(Tax:10116)	25707(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Ciliary_neurotrophic_factor : regulation of acetylcholinesterase in skeletal muscle and distribution of messenger RNA encoding its receptor in synaptic versus extrasynaptic compartments .
23159887	0	acetylcholinesterase	193,213	ColQ	184,188	acetylcholinesterase	ColQ	83817(Tax:10116)	29755(Tax:10116)	Gene	Gene	subunit|nmod|START_ENTITY subunit|appos|END_ENTITY	Expression of cAMP-responsive_element_binding_proteins -LRB- CREBs -RRB- in fast - and slow-twitch muscles : a signaling pathway to account for the synaptic expression of collagen-tailed subunit -LRB- ColQ -RRB- of acetylcholinesterase at the rat neuromuscular junction .
17949411	0	acetylcholinesterase	53,73	GSK3beta	0,8	acetylcholinesterase	GSK3beta	83817(Tax:10116)	84027(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	GSK3beta mediates the induced expression of synaptic acetylcholinesterase during apoptosis .
15878846	0	acetylcholinesterase	37,57	HuR	24,27	acetylcholinesterase	HuR	11423(Tax:10090)	15568(Tax:10090)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	The RNA-binding protein HuR binds to acetylcholinesterase transcripts and regulates their expression in differentiating skeletal muscle cells .
18299393	0	acetylcholinesterase	28,48	Presenilin_1	0,12	acetylcholinesterase	Presenilin 1	11423(Tax:10090)	19164(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Presenilin_1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation .
15039118	0	acetylcholinesterase	111,131	acetylcholinesterase	48,68	acetylcholinesterase	acetylcholinesterase	83817(Tax:10116)	83817(Tax:10116)	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	A peptide derived from the C-terminal region of acetylcholinesterase modulates extracellular concentrations of acetylcholinesterase in the rat substantia nigra .
15039118	0	acetylcholinesterase	48,68	acetylcholinesterase	111,131	acetylcholinesterase	acetylcholinesterase	83817(Tax:10116)	83817(Tax:10116)	Gene	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	A peptide derived from the C-terminal region of acetylcholinesterase modulates extracellular concentrations of acetylcholinesterase in the rat substantia nigra .
9545588	0	acetylcholinesterase	37,57	acetylcholinesterase	92,112	acetylcholinesterase	acetylcholinesterase	83817(Tax:10116)	83817(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	Functional expression of a mammalian acetylcholinesterase in Pichia_pastoris : comparison to acetylcholinesterase , expressed and reconstituted from Escherichia_coli .
9545588	0	acetylcholinesterase	92,112	acetylcholinesterase	37,57	acetylcholinesterase	acetylcholinesterase	83817(Tax:10116)	83817(Tax:10116)	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|nmod|END_ENTITY	Functional expression of a mammalian acetylcholinesterase in Pichia_pastoris : comparison to acetylcholinesterase , expressed and reconstituted from Escherichia_coli .
23897820	0	acetylcholinesterase	54,74	amyloid_precursor_protein	4,29	acetylcholinesterase	amyloid precursor protein	43	351	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The amyloid_precursor_protein represses expression of acetylcholinesterase in neuronal cell lines .
7052505	0	acetylcholinesterase	14,34	nerve_growth_factor	38,57	acetylcholinesterase	nerve growth factor	83817(Tax:10116)	310738(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of acetylcholinesterase by nerve_growth_factor in the pheochromocytoma PC12 cell line .
16212240	0	acetylcholinesterase	30,50	presenilin_2	7,19	acetylcholinesterase	presenilin 2	83817(Tax:10116)	81751(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Mutant presenilin_2 increases acetylcholinesterase activity in neuronal cells .
24323194	0	acetylcholinesterase_type_1	64,91	ace1	98,102	acetylcholinesterase type 1	ace1	692783(Tax:7091)	692783(Tax:7091)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional study on the mutations in the silkworm -LRB- Bombyx_mori -RRB- acetylcholinesterase_type_1 gene -LRB- ace1 -RRB- and its recombinant proteins .
9077451	0	acetyltransferase	34,51	PAT1	0,4	acetyltransferase	PAT1	853237(Tax:4932)	850440(Tax:4932)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	PAT1 , an evolutionarily conserved acetyltransferase homologue , is required for multiple steps in the cell cycle .
7627961	0	acetyltransferase_1	36,55	NAT1	62,66	acetyltransferase 1	NAT1	51471	9	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polyadenylation polymorphism in the acetyltransferase_1 gene -LRB- NAT1 -RRB- increases risk of colorectal_cancer .
8895478	0	acetyltransferase_1	74,93	NAT1	68,72	acetyltransferase 1	NAT1	51471	9	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Lack of association between the polyadenylation polymorphism in the NAT1 -LRB- acetyltransferase_1 -RRB- gene and colorectal_adenomas .
7890770	0	aciculin	15,23	dystrophin	29,39	aciculin	dystrophin	226041(Tax:10090)	24907(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of aciculin with dystrophin and utrophin .
16505147	0	acid-sensing_ion_channel	15,39	ASIC	41,45	acid-sensing ion channel	ASIC	41	41	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of acid-sensing_ion_channel -LRB- ASIC -RRB- 1 with the tarantula toxin psalmotoxin 1 is state dependent .
12578970	0	acid-sensing_ion_channel-1	53,79	protein_interacting_with_C-kinase-1	109,144	acid-sensing ion channel-1	protein interacting with C-kinase-1	41	9463	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	cAMP-dependent protein kinase phosphorylation of the acid-sensing_ion_channel-1 regulates its binding to the protein_interacting_with_C-kinase-1 .
22702502	0	acid-sensing_ion_channel-3	61,87	Eosinophil_peroxidase	0,21	acid-sensing ion channel-3	Eosinophil peroxidase	9311	8288	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Eosinophil_peroxidase induces the expression and function of acid-sensing_ion_channel-3 in allergic_rhinitis : in vitro evidence in cultured epithelial cells .
21257308	0	acid-sensing_ion_channel_3	79,105	ASIC3	107,112	acid-sensing ion channel 3	ASIC3	286920(Tax:10116)	286920(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	High concentration electrophysiology-based fragment screen : discovery of novel acid-sensing_ion_channel_3 -LRB- ASIC3 -RRB- inhibitors .
17696763	0	acid-sensing_ion_channel_3	14,40	p75NTR	118,124	acid-sensing ion channel 3	p75NTR	286920(Tax:10116)	24596(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of acid-sensing_ion_channel_3 -LRB- ASIC3 -RRB- in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling .
21487040	0	acid_ceramidase	15,30	IRF8	0,4	acid ceramidase	IRF8	427	3394	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IRF8 regulates acid_ceramidase expression to mediate apoptosis and suppresses myelogeneous_leukemia .
12409270	0	acid_phosphatase	19,35	ACP1	37,41	acid phosphatase	ACP1	52	52	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the acid_phosphatase -LRB- ACP1 -RRB- gene with triglyceride levels in obese women .
9488730	0	acid_sphingomyelinase	82,103	FADD	56,60	acid sphingomyelinase	FADD	6609	8772	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|dobj|activation	TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid_sphingomyelinase .
9346915	0	acid_sphingomyelinase	14,35	IL-1_receptor_accessory_protein	73,104	acid sphingomyelinase	IL-1 receptor accessory protein	6609	3556	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of acid_sphingomyelinase by interleukin-1 _ -LRB- IL-1 -RRB- requires the IL-1_receptor_accessory_protein .
2004772	0	acid_sphingomyelinase	33,54	SMPD1	61,66	acid sphingomyelinase	SMPD1	6609	6609	Gene	Gene	gene|compound|START_ENTITY assignment|nmod|gene assignment|appos|END_ENTITY	Regional assignment of the human acid_sphingomyelinase gene -LRB- SMPD1 -RRB- by PCR analysis of somatic cell hybrids and in situ hybridization to 11p15 .1 -- p15 .4 .
16636669	0	acid_sphingomyelinase	16,37	TRAIL	0,5	acid sphingomyelinase	TRAIL	6609	8743	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TRAIL activates acid_sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis .
22879933	0	acid_sphingomyelinase	34,55	c-Abl	0,5	acid sphingomyelinase	c-Abl	6609	25	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	c-Abl is an upstream regulator of acid_sphingomyelinase in apoptosis induced by inhibition of integrins avb3 and avb5 .
20236926	0	acid_sphingomyelinase	23,44	tumor_necrosis_factor_alpha	79,106	acid sphingomyelinase	tumor necrosis factor alpha	20597(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Studies on the role of acid_sphingomyelinase and ceramide in the regulation of tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- - converting enzyme activity and TNFalpha secretion in macrophages .
3382640	0	acidic_fibroblast_growth_factor	21,52	Thrombin	0,8	acidic fibroblast growth factor	Thrombin	281160(Tax:9913)	280685(Tax:9913)	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	Thrombin inactivates acidic_fibroblast_growth_factor but not basic fibroblast growth factor .
1701865	0	acidic_fibroblast_growth_factor	16,47	aFGF	49,53	acidic fibroblast growth factor	aFGF	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of acidic_fibroblast_growth_factor -LRB- aFGF -RRB- mRNA in mouse and bovine retina by in situ hybridization .
7507349	0	acidic_fibroblast_growth_factor	28,59	aFGF	61,65	acidic fibroblast growth factor	aFGF	281160(Tax:9913)	281160(Tax:9913)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Developmental regulation of acidic_fibroblast_growth_factor -LRB- aFGF -RRB- expression in bovine retina .
7680120	0	acidic_fibroblast_growth_factor	36,67	aFGF	69,73	acidic fibroblast growth factor	aFGF	2246	2246	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Cloning of two novel forms of human acidic_fibroblast_growth_factor -LRB- aFGF -RRB- mRNA .
9572047	0	acidic_fibroblast_growth_factor	10,41	aFGF	43,47	acidic fibroblast growth factor	aFGF	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of acidic_fibroblast_growth_factor -LRB- aFGF -RRB- on phagocytosis in mouse peritoneal macrophages .
15298798	0	acidic_fibroblast_growth_factor	33,64	acidic_fibroblast_growth_factor	79,110	acidic fibroblast growth factor	acidic fibroblast growth factor	2246	2246	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of reconstructive human acidic_fibroblast_growth_factor and wild type acidic_fibroblast_growth_factor on skin cell proliferation -RSB- .
15298798	0	acidic_fibroblast_growth_factor	79,110	acidic_fibroblast_growth_factor	33,64	acidic fibroblast growth factor	acidic fibroblast growth factor	2246	2246	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of reconstructive human acidic_fibroblast_growth_factor and wild type acidic_fibroblast_growth_factor on skin cell proliferation -RSB- .
23093411	0	acidic_nucleoplasmic_DNA-binding_protein	19,59	And-1	61,66	acidic nucleoplasmic DNA-binding protein	And-1	11169	11169	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	The involvement of acidic_nucleoplasmic_DNA-binding_protein -LRB- And-1 -RRB- in the regulation of prereplicative complex -LRB- pre-RC -RRB- assembly in human cells .
7945995	0	acidic_seminal_fluid_protein	39,67	aSFP	69,73	acidic seminal fluid protein	aSFP	282373(Tax:9913)	282373(Tax:9913)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization and quantitation of acidic_seminal_fluid_protein -LRB- aSFP -RRB- in ejaculated , swim-up , and capacitated bull spermatozoa .
7759998	0	acidic_sphingomyelinase	21,44	CD28	0,4	acidic sphingomyelinase	CD28	6609	940	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	CD28 signals through acidic_sphingomyelinase .
19058849	0	acinus	17,23	gp70	136,140	acinus	gp70	22985	133418	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70 .
21585041	0	acireductone_dioxygenase	55,79	ARD	81,84	acireductone dioxygenase	ARD	55256	55256	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Cloning , molecular characterization and expression of acireductone_dioxygenase -LRB- ARD -RRB- gene from Salvia miltiorrhiza -RSB- .
22172515	0	acl-8	33,38	LYCAT	0,5	acl-8	LYCAT	179031(Tax:6239)	225010(Tax:10090)	Gene	Gene	homologue|amod|START_ENTITY END_ENTITY|appos|homologue	LYCAT , a homologue of C. _ elegans acl-8 , acl-9 , and acl-10 , determines the fatty_acid composition of phosphatidylinositol in mice .
7521127	0	acrosin	14,21	protein_C_inhibitor	25,44	acrosin	protein C inhibitor	49	5104	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acrosin by protein_C_inhibitor and localization of protein_C_inhibitor to spermatozoa .
7521127	0	acrosin	14,21	protein_C_inhibitor	65,84	acrosin	protein C inhibitor	49	5104	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acrosin by protein_C_inhibitor and localization of protein_C_inhibitor to spermatozoa .
8439623	0	acrosin	14,21	trypsin_inhibitor	38,55	acrosin	trypsin inhibitor	49	83716	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Inhibition of acrosin activity with a trypsin_inhibitor blocks human sperm penetration of the zona pellucida .
999042	0	acrosin	12,19	trypsin_inhibitor	36,53	acrosin	trypsin inhibitor	49	83716	Gene	Gene	sperm|compound|START_ENTITY Studies|nmod|sperm END_ENTITY|nsubj|Studies	-LSB- Studies of acrosin and human sperm trypsin_inhibitor activity in human semen .
6488317	0	act88F	31,37	actin	38,43	act88F	actin	41885(Tax:7227)	41885(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A nonsense mutation within the act88F actin gene disrupts myofibril formation in Drosophila indirect flight muscles .
9218799	0	actin	25,30	ACT2	37,41	actin	ACT2	850504(Tax:4932)	851532(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A role for the divergent actin gene , ACT2 , in nuclear pore structure and function .
8754679	0	actin	21,26	ACT7	16,20	actin	ACT7	823805(Tax:3702)	830841(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The arabidopsis ACT7 actin gene is expressed in rapidly developing tissues and responds to several external stimuli .
11281272	0	actin	15,20	CapZ	47,51	actin	CapZ	396526(Tax:9031)	417771(Tax:9031)	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Interaction of actin with the capping protein , CapZ from sea bass -LRB- Dicentrarchus labrax -RRB- white skeletal muscle .
19729655	0	actin	15,20	Rab35	0,5	actin	Rab35	40444(Tax:7227)	33014(Tax:7227)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Rab35 controls actin bundling by recruiting fascin as an effector protein .
15150269	0	actin	120,125	UNC-78	93,99	actin	UNC-78	176793(Tax:6239)	180631(Tax:6239)	Gene	Gene	disassembly|nmod|START_ENTITY Identification|nmod|disassembly Identification|appos|END_ENTITY	Identification of functional residues on Caenorhabditis_elegans actin-interacting_protein_1 -LRB- UNC-78 -RRB- for disassembly of actin depolymerizing factor/cofilin-bound actin filaments .
15150269	0	actin	162,167	UNC-78	93,99	actin	UNC-78	176793(Tax:6239)	180631(Tax:6239)	Gene	Gene	depolymerizing|dobj|START_ENTITY actin|acl|depolymerizing disassembly|nmod|actin Identification|nmod|disassembly Identification|appos|END_ENTITY	Identification of functional residues on Caenorhabditis_elegans actin-interacting_protein_1 -LRB- UNC-78 -RRB- for disassembly of actin depolymerizing factor/cofilin-bound actin filaments .
6488317	0	actin	38,43	act88F	31,37	actin	act88F	41885(Tax:7227)	41885(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A nonsense mutation within the act88F actin gene disrupts myofibril formation in Drosophila indirect flight muscles .
21288906	0	actin	106,111	actin	87,92	actin	actin	850504(Tax:4932)	850504(Tax:4932)	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Allele-specific effects of thoracic_aortic_aneurysm_and_dissection alpha-smooth muscle actin mutations on actin function .
21288906	0	actin	87,92	actin	106,111	actin	actin	850504(Tax:4932)	850504(Tax:4932)	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Allele-specific effects of thoracic_aortic_aneurysm_and_dissection alpha-smooth muscle actin mutations on actin function .
6897014	0	actin	24,29	actin	78,83	actin	actin	528168(Tax:9913)	528168(Tax:9913)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|mRNA mRNA|compound|END_ENTITY	A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA .
6897014	0	actin	78,83	actin	24,29	actin	actin	528168(Tax:9913)	528168(Tax:9913)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|mRNA mRNA|compound|END_ENTITY	A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA .
8977130	0	actin	24,29	casein_kinase_II	33,49	actin	casein kinase II	40444(Tax:7227)	48448(Tax:7227)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	An inhibitory effect of actin on casein_kinase_II activity in vitro .
2645136	0	actin	37,42	deoxyribonuclease_I	122,141	actin	deoxyribonuclease I	528168(Tax:9913)	282217(Tax:9913)	Gene	Gene	Preparation|nmod|START_ENTITY Preparation|nmod|isolation isolation|nmod|END_ENTITY	Preparation of immobilized monomeric actin and its use in the isolation of protease-free and ribonuclease-free pancreatic deoxyribonuclease_I .
3335517	0	actin	60,65	deoxyribonuclease_I	15,34	actin	deoxyribonuclease I	528168(Tax:9913)	1773	Gene	Gene	ends|nmod|START_ENTITY END_ENTITY|nmod|ends	Association of deoxyribonuclease_I with the pointed ends of actin filaments in human red blood cell membrane skeletons .
8250234	0	actin	64,69	deoxyribonuclease_I	87,106	actin	deoxyribonuclease I	528168(Tax:9913)	282217(Tax:9913)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	A fluorometric microplate-based assay of submicrogram monomeric actin by inhibition of deoxyribonuclease_I .
9917396	0	actin	27,32	kettin	15,21	actin	kettin	40444(Tax:7227)	44013(Tax:7227)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of kettin with actin in the Z-disc of insect flight muscle .
21984596	0	actin_filament-associated_protein	28,61	AFAP	63,67	actin filament-associated protein	AFAP	70292(Tax:10090)	70292(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The actin-binding domain of actin_filament-associated_protein -LRB- AFAP -RRB- is involved in the regulation of cytoskeletal structure .
26288717	0	actinin-4	23,32	ACTN4	34,39	actinin-4	ACTN4	81	81	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The biological role of actinin-4 -LRB- ACTN4 -RRB- in malignant phenotypes of cancer .
15002038	0	actinin-alpha4	33,47	DNaseY	14,20	actinin-alpha4	DNaseY	63836(Tax:10116)	116687(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of DNaseY activity by actinin-alpha4 during apoptosis .
10063829	0	actinin-associated_LIM_protein	29,59	ALP	61,64	actinin-associated LIM protein	ALP	27295	27295	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exclusion of muscle specific actinin-associated_LIM_protein -LRB- ALP -RRB- gene from 4q35 facioscapulohumeral muscular_dystrophy -LRB- FSHD -RRB- candidate genes .
15052269	0	activated_B_cell_factor-1	51,76	lymphotoxin-alpha	30,47	activated B cell factor-1	lymphotoxin-alpha	9242	4049	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Allele-specific repression of lymphotoxin-alpha by activated_B_cell_factor-1 .
21560815	0	activated_leukocyte_adhesion_molecule	28,65	ALCAM	67,72	activated leukocyte adhesion molecule	ALCAM	397269(Tax:9823)	397269(Tax:9823)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Side-specific expression of activated_leukocyte_adhesion_molecule -LRB- ALCAM ; CD166 -RRB- in pathosusceptible regions of swine aortic valve endothelium .
7642615	0	activated_protein-1	50,69	CD4	73,76	activated protein-1	CD4	2353	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	HIV-1 envelope glycoproteins induce activation of activated_protein-1 in CD4 + T cells .
23042144	0	activating_protein-1	100,120	Smad_ubiquitination_regulatory_factor_1	54,93	activating protein-1	Smad ubiquitination regulatory factor 1	16476(Tax:10090)	75788(Tax:10090)	Gene	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	Tumor_necrosis_factor-a enhances the transcription of Smad_ubiquitination_regulatory_factor_1 in an activating_protein-1 - and Runx2-dependent manner .
9468519	0	activating_protein-1	8,28	tumor_necrosis_factor-alpha	107,134	activating protein-1	tumor necrosis factor-alpha	3725	7124	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of activating_protein-1 in the regulation of the vascular_cell_adhesion_molecule-1 gene expression by tumor_necrosis_factor-alpha .
15356147	0	activating_transcription_factor-2	81,114	TNF	140,143	activating transcription factor-2	TNF	1386	7124	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Histone_deacetylase_3 , a class I histone deacetylase , suppresses MAPK11-mediated activating_transcription_factor-2 activation and represses TNF gene expression .
19487697	0	activating_transcription_factor-2	126,159	interleukin-13	103,117	activating transcription factor-2	interleukin-13	1386	3596	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	House dust mite allergen Der f 2-induced phospholipase_D1 activation is critical for the production of interleukin-13 through activating_transcription_factor-2 activation in human bronchial epithelial cells .
24973221	0	activating_transcription_factor-3	102,135	ATF-3	137,142	activating transcription factor-3	ATF-3	11910(Tax:10090)	11910(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Metformin suppresses lipopolysaccharide -LRB- LPS -RRB- - induced inflammatory response in murine macrophages via activating_transcription_factor-3 -LRB- ATF-3 -RRB- induction .
21294679	0	activating_transcription_factor-3	25,58	low-density_lipoprotein_receptor	73,105	activating transcription factor-3	low-density lipoprotein receptor	467	3949	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Organelle stress-induced activating_transcription_factor-3 downregulates low-density_lipoprotein_receptor expression in Sk-Hep1 human liver cells .
18227516	0	activating_transcription_factor_2	19,52	ATF2	54,58	activating transcription factor 2	ATF2	11909(Tax:10090)	11909(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Suppressor role of activating_transcription_factor_2 -LRB- ATF2 -RRB- in skin_cancer .
9488727	0	activating_transcription_factor_2	15,48	ATF2	50,54	activating transcription factor 2	ATF2	1386	1386	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of activating_transcription_factor_2 -LRB- ATF2 -RRB- with the ubiquitin-conjugating enzyme hUBC9 .
9488727	0	activating_transcription_factor_2	15,48	hUBC9	94,99	activating transcription factor 2	hUBC9	1386	7329	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of activating_transcription_factor_2 -LRB- ATF2 -RRB- with the ubiquitin-conjugating enzyme hUBC9 .
10318823	0	activating_transcription_factor_2	61,94	tumor_necrosis_factor_alpha	19,46	activating transcription factor 2	tumor necrosis factor alpha	1386	7124	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Down-regulation of tumor_necrosis_factor_alpha expression by activating_transcription_factor_2 increases UVC-induced apoptosis of late-stage melanoma cells .
16019731	0	activating_transcription_factor_3	13,46	ATF3	48,52	activating transcription factor 3	ATF3	25389(Tax:10116)	25389(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of activating_transcription_factor_3 -LRB- ATF3 -RRB- by peripheral_nerve_compression .
18377912	0	activating_transcription_factor_3	43,76	ATF3	78,82	activating transcription factor 3	ATF3	515266(Tax:9913)	515266(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Acute hypoxia to endothelial cells induces activating_transcription_factor_3 -LRB- ATF3 -RRB- expression that is mediated via nitric_oxide .
24939851	0	activating_transcription_factor_3	8,41	ATF3	43,47	activating transcription factor 3	ATF3	467	467	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of activating_transcription_factor_3 -LRB- ATF3 -RRB- in endoplasmic reticulum -LRB- ER -RRB- stress-induced sensitization of p53-deficient human colon_cancer cells to tumor necrosis factor -LRB- TNF -RRB- - related apoptosis-inducing ligand -LRB- TRAIL -RRB- - mediated apoptosis through up-regulation of death_receptor_5 -LRB- DR5 -RRB- by zerumbone and celecoxib .
17178897	0	activating_transcription_factor_3	76,109	Drg-1	37,42	activating transcription factor 3	Drg-1	11910(Tax:10090)	13494(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	The tumor metastasis suppressor gene Drg-1 down-regulates the expression of activating_transcription_factor_3 in prostate_cancer .
20600850	0	activating_transcription_factor_3	31,64	STAT1	17,22	activating transcription factor 3	STAT1	11910(Tax:10090)	20846(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	The induction of STAT1 gene by activating_transcription_factor_3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice .
12161427	0	activating_transcription_factor_3	26,59	p53	186,189	activating transcription factor 3	p53	467	7157	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|down-regulation down-regulation|nmod|transcription transcription|compound|END_ENTITY	Transcriptional repressor activating_transcription_factor_3 protects human umbilical vein endothelial cells from tumor_necrosis_factor-alpha-induced apoptosis through down-regulation of p53 transcription .
16847457	0	activating_transcription_factor_3	13,46	p53	75,78	activating transcription factor 3	p53	467	7157	Gene	Gene	Induction|nmod|START_ENTITY independent|nsubj|Induction independent|nmod|END_ENTITY	Induction of activating_transcription_factor_3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway .
17108111	0	activating_transcription_factor_3	97,130	p53	7,10	activating transcription factor 3	p53	467	7157	Gene	Gene	induction|amod|START_ENTITY attenuating|dobj|induction protects|advcl|attenuating protects|nsubj|END_ENTITY	Mutant p53 protects cells from 12-O-tetradecanoylphorbol-13-acetate-induced death by attenuating activating_transcription_factor_3 induction .
24554706	0	activating_transcription_factor_3	4,37	p53	90,93	activating transcription factor 3	p53	467	7157	Gene	Gene	protein|amod|START_ENTITY suppresses|nsubj|protein suppresses|dobj|function function|nmod|proteins proteins|compound|END_ENTITY	The activating_transcription_factor_3 protein suppresses the oncogenic function of mutant p53 proteins .
10509809	0	activating_transcription_factor_4	12,45	ATF4	47,51	activating transcription factor 4	ATF4	468	468	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of activating_transcription_factor_4 -LRB- ATF4 -RRB- in the porcine anterior pituitary .
24100623	0	activating_transcription_factor_4	17,50	ATF4	52,56	activating transcription factor 4	ATF4	468	468	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	SIRT1 suppresses activating_transcription_factor_4 -LRB- ATF4 -RRB- expression in response to proteasome inhibition .
19913500	0	activating_transcription_factor_4	62,95	Fibroblast_growth_factor_2	0,26	activating transcription factor 4	Fibroblast growth factor 2	11911(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Fibroblast_growth_factor_2 positively regulates expression of activating_transcription_factor_4 in osteoblasts .
27010621	0	activating_transcription_factor_4	41,74	Fibroblast_growth_factor_21	0,27	activating transcription factor 4	Fibroblast growth factor 21	468	26291	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Fibroblast_growth_factor_21 induction by activating_transcription_factor_4 is regulated through three amino acid response elements in its promoter region .
21148039	0	activating_transcription_factor_4	42,75	IRF7	23,27	activating transcription factor 4	IRF7	468	3665	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Negative regulation of IRF7 activation by activating_transcription_factor_4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses .
22528486	0	activating_transcription_factor_5	40,73	ATF5	75,79	activating transcription factor 5	ATF5	22809	22809	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Nucleophosmin -LRB- NPM1/B23 -RRB- interacts with activating_transcription_factor_5 -LRB- ATF5 -RRB- protein and promotes proteasome - and caspase-dependent ATF5 degradation in hepatocellular_carcinoma cells .
24379400	0	activating_transcription_factor_5	38,71	ATF5	73,77	activating transcription factor 5	ATF5	22809	22809	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	N-terminal hydrophobic amino_acids of activating_transcription_factor_5 -LRB- ATF5 -RRB- protein confer interleukin_1b -LRB- IL-1b -RRB- - induced stabilization .
15358120	0	activating_transcription_factor_5	31,64	Cyclin_D3	0,9	activating transcription factor 5	Cyclin D3	22809	896	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cyclin_D3 interacts with human activating_transcription_factor_5 and potentiates its transcription activity .
20165829	0	activating_transcription_factor_6	78,111	GLUT4	57,62	activating transcription factor 6	GLUT4	304962(Tax:10116)	25139(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Glucosamine-induced endoplasmic_reticulum_stress affects GLUT4 expression via activating_transcription_factor_6 in rat and human skeletal muscle cells .
20663776	0	activation-induced_C-type_lectin	67,99	killer_cell_lectin-like_receptor_F1	116,151	activation-induced C-type lectin	killer cell lectin-like receptor F1	9976	51348	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Tumor cells of non-hematopoietic and hematopoietic origins express activation-induced_C-type_lectin , the ligand for killer_cell_lectin-like_receptor_F1 .
16005067	0	activation-induced_cytidine_deaminase	63,100	AICDA	102,107	activation-induced cytidine deaminase	AICDA	11628(Tax:10090)	11628(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a ubiquitously active promoter of the murine activation-induced_cytidine_deaminase -LRB- AICDA -RRB- gene .
10950930	0	activation-induced_cytidine_deaminase	74,111	AID	113,116	activation-induced cytidine deaminase	AID	57379	57379	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation , tissue distribution , and chromosomal localization of the human activation-induced_cytidine_deaminase -LRB- AID -RRB- gene .
14961036	0	activation-induced_cytidine_deaminase	19,56	AID	58,61	activation-induced cytidine deaminase	AID	57379	57379	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	High expression of activation-induced_cytidine_deaminase -LRB- AID -RRB- mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic_lymphocytic_leukaemia .
15732141	0	activation-induced_cytidine_deaminase	27,64	AID	66,69	activation-induced cytidine deaminase	AID	57379	57379	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of activation-induced_cytidine_deaminase -LRB- AID -RRB- in nodular lymphocyte-predominant and classical Hodgkin_lymphoma .
16574227	0	activation-induced_cytidine_deaminase	22,59	AID	61,64	activation-induced cytidine deaminase	AID	57379	57379	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Somatic mutations and activation-induced_cytidine_deaminase -LRB- AID -RRB- expression in established rheumatoid factor-producing lymphoblastoid cell line .
18450484	0	activation-induced_cytidine_deaminase	40,77	MicroRNA-155	0,12	activation-induced cytidine deaminase	MicroRNA-155	11628(Tax:10090)	387173(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MicroRNA-155 is a negative regulator of activation-induced_cytidine_deaminase .
25775145	0	activation-induced_cytidine_deaminase	89,126	miR-155	28,35	activation-induced cytidine deaminase	miR-155	57379	406947	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulated expression of miR-155 , miR-17 , and miR-181b , and upregulated expression of activation-induced_cytidine_deaminase and interferon-a in PBMCs from patients with SLE .
11847344	0	activation-induced_deaminase	19,47	AID	49,52	activation-induced deaminase	AID	418257(Tax:9031)	418257(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Requirement of the activation-induced_deaminase -LRB- AID -RRB- gene for immunoglobulin gene conversion .
25006166	0	activation_induced_cytidine_deaminase	70,107	AID	109,112	activation induced cytidine deaminase	AID	57379	57379	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Induction of homologous recombination between sequence repeats by the activation_induced_cytidine_deaminase -LRB- AID -RRB- protein .
8386622	0	activator-protein-1	132,151	AP-1	153,157	activator-protein-1	AP-1	3725	3725	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Synergism between protein-kinase C and cAMP-dependent pathways in the expression of the interleukin-1_beta gene is mediated via the activator-protein-1 -LRB- AP-1 -RRB- enhancer activity .
24307516	0	activator_of_G-protein_signaling_3	11,45	AGS3	47,51	activator of G-protein signaling 3	AGS3	26086	26086	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for activator_of_G-protein_signaling_3 -LRB- AGS3 -RRB- in multiple_myeloma .
11230805	0	activator_protein-1	62,81	AP-1	83,87	activator protein-1	AP-1	24516(Tax:10116)	24516(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Tissue-specific regulation of glutathione homeostasis and the activator_protein-1 -LRB- AP-1 -RRB- response in the rat conceptus .
12757717	0	activator_protein-1	133,152	AP-1	154,158	activator protein-1	AP-1	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	New unusual iridoids from the leaves of noni -LRB- Morinda citrifolia L. -RRB- show inhibitory effect on ultraviolet B-induced transcriptional activator_protein-1 -LRB- AP-1 -RRB- activity .
8001557	0	activator_protein-1	14,33	AP-1	35,39	activator protein-1	AP-1	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Modulation of activator_protein-1 -LRB- AP-1 -RRB- transcription factor and protein kinase C by hydrogen_peroxide and D-alpha-tocopherol in vascular smooth muscle cells .
9254885	0	activator_protein-1	15,34	AP-1	36,40	activator protein-1	AP-1	3727	3727	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of activator_protein-1 -LRB- AP-1 -RRB- in induction of apoptosis by vitamin_E_succinate in human breast_cancer cells .
9334204	0	activator_protein-1	36,55	AP-1	57,61	activator protein-1	AP-1	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of ultraviolet B-induced activator_protein-1 -LRB- AP-1 -RRB- activity by aspirin in AP-1-luciferase transgenic_mice .
26137108	0	activator_protein-1	58,77	Heat_shock_protein_27	0,21	activator protein-1	Heat shock protein 27	16476(Tax:10090)	15507(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Heat_shock_protein_27 promotes cell proliferation through activator_protein-1 in lung_cancer .
15754027	0	activator_protein-1	72,91	Heat_shock_protein_90	0,21	activator protein-1	Heat shock protein 90	16476(Tax:10090)	104434(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	Heat_shock_protein_90 is required for increased DNA binding activity of activator_protein-1 , a heterodimer of Fos/JunD , in rheumatoid synovial cells under inflammatory stimuli .
16168987	0	activator_protein-1	160,179	Jun_N-terminal_kinase	138,159	activator protein-1	Jun N-terminal kinase	24516(Tax:10116)	116554(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Nicotinamide blocks N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in rats through poly _ -LRB- ADP-ribose -RRB- polymerase activity and Jun_N-terminal_kinase / activator_protein-1 pathway inhibition .
20619258	0	activator_protein-1	115,134	MUC5AC	65,71	activator protein-1	MUC5AC	3726	4586	Gene	Gene	cells|amod|START_ENTITY inhibition|nmod|cells inhibits|nmod|inhibition inhibits|dobj|expression expression|nummod|END_ENTITY	Azithromycin inhibits nontypeable Haemophilus_influenzae-induced MUC5AC expression and secretion via inhibition of activator_protein-1 in human airway epithelial cells .
21131736	0	activator_protein-1	25,44	MUC5AC	66,72	activator protein-1	MUC5AC	16476(Tax:10090)	17833(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Regulatory mechanism of activator_protein-1 on the expression of MUC5AC induced by cigarette_smoke_extract -RSB- .
20042607	0	activator_protein-1	17,36	SIRT1	0,5	activator protein-1	SIRT1	3725	23411	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	SIRT1 suppresses activator_protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages .
11722647	0	activator_protein-1	88,107	THP-1	140,145	activator protein-1	THP-1	3726	2736	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Acholeplasma_laidlawii up-regulates granulysin gene expression via transcription factor activator_protein-1 in a human monocytic cell line , THP-1 .
17895291	0	activator_protein-1	58,77	connexin_43	42,53	activator protein-1	connexin 43	2353	2697	Gene	Gene	factor|amod|START_ENTITY END_ENTITY|nmod|factor	Corticotropin-releasing_hormone activates connexin_43 via activator_protein-1 transcription factor in human myometrial smooth muscle cells .
16964287	0	activator_protein-1	90,109	cyclin_D1	136,145	activator protein-1	cyclin D1	3725	595	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Involvement of protein phosphatase_2A nuclear accumulation and subsequent inactivation of activator_protein-1 in leptomycin_B-inhibited cyclin_D1 expression .
10473669	0	activator_protein-1	157,176	endothelin-1	79,91	activator protein-1	endothelin-1	3725	1906	Gene	Gene	pathway|amod|START_ENTITY inhibiting|dobj|pathway inhibit|advcl|inhibiting inhibit|dobj|production production|amod|END_ENTITY	Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator_protein-1 signaling pathway .
12193048	0	activator_protein-1	38,57	endothelin-1	16,28	activator protein-1	endothelin-1	24516(Tax:10116)	24323(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Contribution of endothelin-1 to renal activator_protein-1 activation and macrophage infiltration in aldosterone-induced hypertension .
11007940	0	activator_protein-1	38,57	nuclear_factor-kappa_B	14,36	activator protein-1	nuclear factor-kappa B	3725	4790	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Regulation of nuclear_factor-kappa_B , activator_protein-1 , and glutathione levels by tumor_necrosis_factor-alpha and dexamethasone in alveolar epithelial cells .
12733991	0	activator_protein-2gamma	30,54	AP-2gamma	56,65	activator protein-2gamma	AP-2gamma	7022	7022	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the human activator_protein-2gamma -LRB- AP-2gamma -RRB- gene : control of expression by Sp1/Sp3 in breast_tumour cells .
15480426	0	activator_protein_1	22,41	AP-1	43,47	activator protein 1	AP-1	3725	3725	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Thioredoxin modulates activator_protein_1 -LRB- AP-1 -RRB- activity and p27Kip1 degradation through direct interaction with Jab1 .
21940623	0	activator_protein_1	136,155	AP-1	157,161	activator protein 1	AP-1	3725	3725	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Prostaglandin_E2 induces matrix_metalloproteinase_9 expression in dendritic cells through two independent signaling pathways leading to activator_protein_1 -LRB- AP-1 -RRB- activation .
19221002	0	activator_protein_1	104,123	EGF	135,138	activator protein 1	EGF	2353	1950	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Tpl-2 kinase downregulates the activity of p53 and enhances signaling pathways leading to activation of activator_protein_1 induced by EGF .
23904356	0	activator_protein_1	35,54	Fra	0,3	activator protein 1	Fra	2354	8061	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Fra , Fra away : the complex role of activator_protein_1 in liver_injury .
23904356	0	activator_protein_1	35,54	Fra	5,8	activator protein 1	Fra	2354	8061	Gene	Gene	role|nmod|START_ENTITY Fra|dep|role Fra|advmod|away away|dep|END_ENTITY	Fra , Fra away : the complex role of activator_protein_1 in liver_injury .
27065323	0	activator_protein_1	47,66	Glutathione_S-transferase_alpha_4	0,33	activator protein 1	Glutathione S-transferase alpha 4	3725	2941	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Glutathione_S-transferase_alpha_4 induction by activator_protein_1 in colorectal_cancer .
15480426	0	activator_protein_1	22,41	Thioredoxin	0,11	activator protein 1	Thioredoxin	3725	7295	Gene	Gene	activity|amod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Thioredoxin modulates activator_protein_1 -LRB- AP-1 -RRB- activity and p27Kip1 degradation through direct interaction with Jab1 .
17363560	0	activator_protein_1	18,37	cyclooxygenase-2	54,70	activator protein 1	cyclooxygenase-2	16476(Tax:10090)	19225(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	Dominant-negative activator_protein_1 -LRB- TAM67 -RRB- targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis .
12082627	0	activator_protein_1	57,76	death_receptor_4	24,40	activator protein 1	death receptor 4	3726	8797	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Evidence that the human death_receptor_4 is regulated by activator_protein_1 .
22102411	0	activator_protein_1	99,118	interleukin-1b	7,21	activator protein 1	interleukin-1b	3726	3553	Gene	Gene	factors|amod|START_ENTITY element|nmod|factors IL-1b|dep|element IL-1b|amod|END_ENTITY	Distal interleukin-1b -LRB- IL-1b -RRB- response element of human matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- binds activator_protein_1 -LRB- AP-1 -RRB- transcription factors and regulates gene expression .
9218873	0	activator_protein_1	155,174	jun	131,134	activator protein 1	jun	3725	3725	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Transcriptional regulation of intercellular_adhesion_molecule_1 by phorbol_ester in human neuroblastoma cell line SK-N-SH involves jun - and fos-containing activator_protein_1 site binding complex -LRB- es -RRB- .
10972989	0	activator_protein_1	83,102	p38	8,11	activator protein 1	p38	2353	1432	Gene	Gene	activation|amod|START_ENTITY kinases|nmod|activation kinases|nsubj|Role Role|nmod|protein protein|amod|END_ENTITY	Role of p38 mitogen-activated protein kinases in ultraviolet-B irradiation-induced activator_protein_1 activation in human keratinocytes .
17689131	0	activator_protein_1	51,70	p38	37,40	activator protein 1	p38	3725	1432	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The mitogen-activated protein kinase p38 regulates activator_protein_1 by direct phosphorylation of c-Jun .
11266514	0	activator_protein_1	92,111	prolactin	59,68	activator protein 1	prolactin	3725	5617	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Identification of a decidua-specific enhancer on the human prolactin gene with two critical activator_protein_1 -LRB- AP-1 -RRB- binding sites .
15870067	0	activator_protein_2	27,46	Yin_Yang_1	0,10	activator protein 2	Yin Yang 1	7020	7528	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Yin_Yang_1 cooperates with activator_protein_2 to stimulate ERBB2 gene expression in mammary cancer cells .
12665502	0	activin	48,55	ALK4	79,83	activin	ALK4	83729	91	Gene	Gene	site|nmod|START_ENTITY Identification|nmod|site Identification|nmod|END_ENTITY	Identification of a functional binding site for activin on the type I receptor ALK4 .
11117535	0	activin	10,17	Alk4	34,38	activin	Alk4	83729	91	Gene	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling .
7684983	0	activin	22,29	Follistatin	0,11	activin	Follistatin	83729	10468	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Follistatin modulates activin activity in a cell - and tissue-specific manner .
20233786	0	activin	22,29	FoxL2	0,5	activin	FoxL2	83729	26927(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	FoxL2 Is required for activin induction of the mouse and human follicle-stimulating_hormone_beta-subunit genes .
10342830	0	activin	50,57	PA-1	112,116	activin	PA-1	83729	79447	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Differential response to exogenous and endogenous activin in a human ovarian_teratocarcinoma-derived cell line -LRB- PA-1 -RRB- : regulation by cell surface follistatin .
10652306	0	activin	48,55	activin	69,76	activin	activin	83729	83729	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Identification of a binding site on the type II activin receptor for activin and inhibin .
10652306	0	activin	69,76	activin	48,55	activin	activin	83729	83729	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Identification of a binding site on the type II activin receptor for activin and inhibin .
7600958	0	activin	113,120	follistatin	139,150	activin	follistatin	83729	14313(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Expression of inhibin subunits and follistatin during postimplantation mouse development : decidual expression of activin and expression of follistatin in primitive streak , somites and hindbrain .
22761777	0	activin	11,18	p21	31,34	activin	p21	83729	1026	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of activin and TGFb on p21 in colon_cancer .
1704219	0	activin-binding_protein	23,46	follistatin	48,59	activin-binding protein	follistatin	399282(Tax:8355)	399282(Tax:8355)	Gene	Gene	mRNA|nmod|START_ENTITY Expression|nmod|mRNA Expression|appos|END_ENTITY	Expression of mRNA for activin-binding_protein -LRB- follistatin -RRB- during early embryonic development of Xenopus_laevis .
23973291	0	activin_A	28,37	BDNF	48,52	activin A	BDNF	29200(Tax:10116)	627	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	TGF-beta superfamily member activin_A acts with BDNF and erythropoietin to improve survival of spiral_ganglion_neurons in vitro .
12615714	0	activin_A_type_II_receptor	68,94	ACVR2	96,101	activin A type II receptor	ACVR2	92	92	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence of selection for clones having genetic inactivation of the activin_A_type_II_receptor -LRB- ACVR2 -RRB- gene in gastrointestinal_cancers .
18421620	0	activin_receptor-like_kinase-5	95,125	ALK5	127,131	activin receptor-like kinase-5	ALK5	7046	7046	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Identification of human cytochrome_P450 enzymes involved in the metabolism of IN-1130 , a novel activin_receptor-like_kinase-5 -LRB- ALK5 -RRB- inhibitor .
17219009	0	activin_receptor-like_kinase_1	29,59	ALK-1	61,66	activin receptor-like kinase 1	ALK-1	94	94	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Three novel mutations in the activin_receptor-like_kinase_1 -LRB- ALK-1 -RRB- gene in hereditary_hemorrhagic_telangiectasia_type_2 in Brazilian patients .
15059530	0	activin_receptor-like_kinase_1	17,47	ALK1	48,52	activin receptor-like kinase 1	ALK1	94	94	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Mutation of the activin_receptor-like_kinase_1 -LRB- ALK1 -RRB- gene and the expression of plasma thrombomodulin in type-2 hereditary_hemorrhagic_telangiectasia : a study of a Chinese family -RSB- .
18159113	0	activin_receptor-like_kinase_1	29,59	ALK1	66,70	activin receptor-like kinase 1	ALK1	94	94	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Implications of mutations of activin_receptor-like_kinase_1 gene -LRB- ALK1 -RRB- in addition to bone morphogenetic protein receptor II gene -LRB- BMPR2 -RRB- in children with pulmonary_arterial_hypertension .
17657819	0	activin_receptor-like_kinase_5	46,76	transforming_growth_factor-beta	14,45	activin receptor-like kinase 5	transforming growth factor-beta	7046	7040	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Profibrogenic transforming_growth_factor-beta / activin_receptor-like_kinase_5 signaling via connective_tissue_growth_factor expression in hepatocytes .
20848923	0	activin_receptor-like_kinase_5	61,91	transforming_growth_factor-beta_3	26,59	activin receptor-like kinase 5	transforming growth factor-beta 3	21812(Tax:10090)	21809(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- The preliminary study on transforming_growth_factor-beta_3 , activin_receptor-like_kinase_5 expression in 2 , 3 , 7 , 8-tetrachloro-p-dibenzodioxin and dexamethasone induced palatal_cleft in mice -RSB- .
8995483	0	activin_receptor_type_II	22,46	ACVR2	53,58	activin receptor type II	ACVR2	281598(Tax:9913)	281598(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning of the bovine activin_receptor_type_II gene -LRB- ACVR2 -RRB- and mapping to chromosome 2 -LRB- BTA2 -RRB- .
12752499	0	activin_type_IB_receptor	28,52	XALK4	54,59	activin type IB receptor	XALK4	399454(Tax:8355)	399454(Tax:8355)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunocytochemical study of activin_type_IB_receptor -LRB- XALK4 -RRB- in Xenopus oocytes .
12112458	0	activin_type_IIB_receptor	86,111	ActRIIB	113,120	activin type IIB receptor	ActRIIB	11481(Tax:10090)	11481(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Gene-dosage-sensitive genetic interactions between inversus viscerum -LRB- iv -RRB- , nodal , and activin_type_IIB_receptor -LRB- ActRIIB -RRB- genes in asymmetrical patterning of the visceral organs along the left-right axis .
15974912	0	activity-dependent_neuroprotective_protein	18,60	ADNP	62,66	activity-dependent neuroprotective protein	ADNP	11538(Tax:10090)	11538(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- is regulated by brain_damage and treatment of mice with the ADNP derived peptide , NAP , reduces the severity of traumatic head_injury .
17952637	0	activity-dependent_neuroprotective_protein	46,88	ADNP	90,94	activity-dependent neuroprotective protein	ADNP	11538(Tax:10090)	11538(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vasoactive intestinal peptide -LRB- VIP -RRB- regulates activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- expression in vivo .
18375135	0	activity-dependent_neuroprotective_protein	14,56	ADNP	58,62	activity-dependent neuroprotective protein	ADNP	23394	23394	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of activity-dependent_neuroprotective_protein -LRB- ADNP -RRB- by the NO-cGMP pathway in the hippocampus during kainic_acid-induced seizure .
21267468	0	activity-dependent_neuroprotective_protein	13,55	HP1	0,3	activity-dependent neuroprotective protein	HP1	23394	23468	Gene	Gene	recruits|xcomp|START_ENTITY recruits|nsubj|END_ENTITY	HP1 recruits activity-dependent_neuroprotective_protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats .
21664256	0	activity-regulated_cytoskeletal-associated_protein	16,66	Arc	68,71	activity-regulated cytoskeletal-associated protein	Arc	11838(Tax:10090)	11838(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Novelty-induced activity-regulated_cytoskeletal-associated_protein -LRB- Arc -RRB- expression in frontal cortex requires serotonin 2A receptor activation .
19576731	0	activity-regulated_cytoskeletal_associated_protein	37,87	Arc	89,92	activity-regulated cytoskeletal associated protein	Arc	54323(Tax:10116)	54323(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression and modulation of activity-regulated_cytoskeletal_associated_protein -LRB- Arc -RRB- in serotonin_transporter knockout rats .
21515256	0	activity-regulated_cytoskeleton-associated_protein	47,97	brain-derived_neurotrophic_factor	10,43	activity-regulated cytoskeleton-associated protein	brain-derived neurotrophic factor	54323(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of brain-derived_neurotrophic_factor on activity-regulated_cytoskeleton-associated_protein gene expression in primary_frontal_cortical_neurons .
19159662	0	activity-regulated_cytoskeleton_associated_protein	20,70	Arc	72,75	activity-regulated cytoskeleton associated protein	Arc	23237	23237	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Estrogen stimulates activity-regulated_cytoskeleton_associated_protein -LRB- Arc -RRB- expression via the MAPK - and PI-3K-dependent pathways in SH-SY5Y cells .
23056266	0	actopaxin	20,29	Beta2-adaptin	0,13	actopaxin	Beta2-adaptin	55742	163	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Beta2-adaptin binds actopaxin and regulates cell spreading , migration and matrix degradation .
16860736	0	actopaxin	22,31	CdGAP	0,5	actopaxin	CdGAP	55742	57514	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility .
12688541	0	acute_phase_protein	78,97	Interleukin-1beta	34,51	acute phase protein	Interleukin-1beta	351	3553	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Growth_hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute_phase_protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3 .
8662591	0	acute_phase_response_factor	27,54	STAT3	55,60	acute phase response factor	STAT3	6774	6774	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Differential activation of acute_phase_response_factor / STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130 .
8662795	0	acute_phase_response_factor	27,54	Stat3	55,60	acute phase response factor	Stat3	6774	6774	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Differential activation of acute_phase_response_factor / Stat3 and Stat1 via the cytoplasmic domain of the interleukin_6 signal transducer gp130 .
11267899	0	acyl-CoA-binding_protein	20,44	ACBP	46,50	acyl-CoA-binding protein	ACBP	692574(Tax:7091)	692574(Tax:7091)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of acyl-CoA-binding_protein -LRB- ACBP -RRB- in the pheromone gland of the silkworm , Bombyx_mori .
17262885	0	acyl-CoA-binding_protein	15,39	ACBP	41,45	acyl-CoA-binding protein	ACBP	1622	1622	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of acyl-CoA-binding_protein -LRB- ACBP -RRB- single nucleotide polymorphisms and type_2_diabetes in two German study populations .
20079838	0	acyl-CoA-binding_protein	23,47	ACBP	49,53	acyl-CoA-binding protein	ACBP	1622	1622	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Serotonin regulates an acyl-CoA-binding_protein -LRB- ACBP -RRB- gene expression in the midgut of Rhodnius prolixus .
21079819	0	acyl-CoA-binding_protein	78,102	ACBP	104,108	acyl-CoA-binding protein	ACBP	1622	1622	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Expression , purification and functional characterization of recombinant human acyl-CoA-binding_protein -LRB- ACBP -RRB- from erythroid cells .
8232254	0	acyl-CoA-binding_protein	16,40	ACBP	42,46	acyl-CoA-binding protein	ACBP	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	The function of acyl-CoA-binding_protein -LRB- ACBP -RRB- / diazepam_binding_inhibitor -LRB- DBI -RRB- .
8075791	0	acyl-CoA-binding_protein	45,69	diazepam-binding_inhibitor	18,44	acyl-CoA-binding protein	diazepam-binding inhibitor	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	START_ENTITY|dep|Inhibition Inhibition|nmod|END_ENTITY	Inhibition by rat diazepam-binding_inhibitor / acyl-CoA-binding_protein of glucose-induced insulin secretion in the rat .
10924347	0	acyl-CoA_synthetase_4	80,101	adrenocorticotropic_hormone	14,41	acyl-CoA synthetase 4	adrenocorticotropic hormone	2182	5443	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Regulation by adrenocorticotropic_hormone and arachidonate of the expression of acyl-CoA_synthetase_4 , an arachidonate-preferring enzyme expressed in steroidogenic tissues .
24462768	0	acyl-CoA_synthetase_long-chain_family_member_1	76,122	ACSL1	124,129	acyl-CoA synthetase long-chain family member 1	ACSL1	2180	2180	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	MiR-205 modulates abnormal lipid metabolism of hepatoma cells via targeting acyl-CoA_synthetase_long-chain_family_member_1 -LRB- ACSL1 -RRB- mRNA .
18178100	0	acyl_coenzyme_A_binding_protein	81,112	ACBP	114,118	acyl coenzyme A binding protein	ACBP	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Structural and functional characterization of a new recombinant histidine-tagged acyl_coenzyme_A_binding_protein -LRB- ACBP -RRB- from mouse .
17453651	0	acyl_coenzyme_A_synthetase_long-chain_1	48,87	ACSL1	89,94	acyl coenzyme A synthetase long-chain 1	ACSL1	448982(Tax:9823)	448982(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nucleotide sequence and polymorphism of the pig acyl_coenzyme_A_synthetase_long-chain_1 -LRB- ACSL1 -RRB- gene .
22415731	0	acylglycerol_kinase	43,62	AGK	64,67	acylglycerol kinase	AGK	55750	55750	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a truncation mutation of acylglycerol_kinase -LRB- AGK -RRB- gene in a novel autosomal recessive cataract locus .
16815140	0	acyloxyacyl_hydroxylase	32,55	AOAH	57,61	acyloxyacyl hydroxylase	AOAH	313	313	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms in the novel gene acyloxyacyl_hydroxylase -LRB- AOAH -RRB- are associated with asthma and associated phenotypes .
10719179	0	acylpeptide_hydrolase	70,91	oxidized_protein_hydrolase	18,44	acylpeptide hydrolase	oxidized protein hydrolase	327	327	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of oxidized_protein_hydrolase of human erythrocytes as acylpeptide_hydrolase .
12809673	0	ada	66,69	adenosine_deaminase	45,64	ada	adenosine deaminase	100	100	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Linkage disequilibrium analysis of the human adenosine_deaminase -LRB- ada -RRB- gene provides evidence for a lack of correlation between hot spots of equal and unequal homologous recombination .
18802088	0	adapter_protein	102,117	ADAP	118,122	adapter protein	ADAP	23880(Tax:10090)	23880(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa_B activation by the adapter_protein ADAP .
15153494	0	adapter_protein	156,171	FcepsilonRI	175,186	adapter protein	FcepsilonRI	2533	2205	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Differential requirement for adapter_proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion - and degranulation-promoting adapter_protein in FcepsilonRI signaling and mast cell function .
9049247	0	adaptor_protein-2	45,62	Eps15	34,39	adaptor protein-2	Eps15	7020	2060	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association and colocalization of Eps15 with adaptor_protein-2 and clathrin .
19419997	0	adaptor_protein_2	56,73	KIAA0319	32,40	adaptor protein 2	KIAA0319	7020	9856	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The dyslexia-associated protein KIAA0319 interacts with adaptor_protein_2 and follows the classical clathrin-mediated endocytosis pathway .
24708097	0	adaptor_protein_2_sigma_subunit	27,58	AP2S1	60,65	adaptor protein 2 sigma subunit	AP2S1	1175	1175	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the adaptor_protein_2_sigma_subunit -LRB- AP2S1 -RRB- gene : search for autosomal dominant hypocalcemia type 3 -LRB- ADH3 -RRB- .
22542624	0	additional_sex_comb-like_1	23,49	SOX2	93,97	additional sex comb-like 1	SOX2	228790(Tax:10090)	20674(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Positive regulation of additional_sex_comb-like_1 gene expression by the pluripotency factor SOX2 .
21791202	0	adducin	11,18	Dlg	29,32	adducin	Dlg	37230(Tax:7227)	32083(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane .
8939809	0	ade2	117,121	ade2	137,141	ade2	ade2	854295(Tax:4932)	854295(Tax:4932)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	The red/white colony color assay in the yeast Saccharomyces_cerevisiae : epistatic growth advantage of white ade8-18 , ade2 cells over red ade2 cells .
8939809	0	ade2	137,141	ade2	117,121	ade2	ade2	854295(Tax:4932)	854295(Tax:4932)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|cells cells|amod|END_ENTITY	The red/white colony color assay in the yeast Saccharomyces_cerevisiae : epistatic growth advantage of white ade8-18 , ade2 cells over red ade2 cells .
1746557	0	adenine_phosphoribosyltransferase	52,85	APRT	87,91	adenine phosphoribosyltransferase	APRT	353	353	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a single missense mutation in the adenine_phosphoribosyltransferase -LRB- APRT -RRB- gene from five Icelandic patients and a British patient .
3780312	0	adenine_phosphoribosyltransferase	29,62	APRT	69,73	adenine phosphoribosyltransferase	APRT	353	353	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new location for the human adenine_phosphoribosyltransferase gene -LRB- APRT -RRB- distal to the haptoglobin -LRB- HP -RRB- and fra -LRB- 16 -RRB- -LRB- q23 -RRB- -LRB- FRA16D -RRB- loci .
6087472	0	adenine_phosphoribosyltransferase	30,63	APRT	65,69	adenine phosphoribosyltransferase	APRT	353	353	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning of a functional human adenine_phosphoribosyltransferase -LRB- APRT -RRB- gene : identification of a restriction fragment length polymorphism and preliminary analysis of DNAs from APRT-deficient families and cell mutants .
9521589	0	adenine_phosphoribosyltransferase	68,101	APRT	103,107	adenine phosphoribosyltransferase	APRT	353	353	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A germline mutation abolishing the original stop codon of the human adenine_phosphoribosyltransferase -LRB- APRT -RRB- gene leads to complete loss of the enzyme protein .
3780312	0	adenine_phosphoribosyltransferase	29,62	FRA16D	123,129	adenine phosphoribosyltransferase	FRA16D	353	2463	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new location for the human adenine_phosphoribosyltransferase gene -LRB- APRT -RRB- distal to the haptoglobin -LRB- HP -RRB- and fra -LRB- 16 -RRB- -LRB- q23 -RRB- -LRB- FRA16D -RRB- loci .
7604852	0	adenomatous_polyposis_coli	35,61	APC	68,71	adenomatous polyposis coli	APC	324	324	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	High resolution genetic map of the adenomatous_polyposis_coli gene -LRB- APC -RRB- region .
15020226	0	adenomatous_polyposis_coli	23,49	MUC1	0,4	adenomatous polyposis coli	MUC1	324	4582	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	MUC1 can interact with adenomatous_polyposis_coli in breast_cancer .
2108904	0	adenosine3	24,34	Gart	36,40	adenosine3	Gart	33986(Tax:7227)	33986(Tax:7227)	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Genetic analysis of the adenosine3 -LRB- Gart -RRB- region of the second chromosome of Drosophila_melanogaster .
21291865	0	adenosine_A1_receptor	57,78	EAAT2	32,37	adenosine A1 receptor	EAAT2	134	6506	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of ethanol-sensitive EAAT2 expression through adenosine_A1_receptor in astrocytes .
23609277	0	adenosine_A1_receptor	121,142	PKCa	98,102	adenosine A1 receptor	PKCa	29290(Tax:10116)	24680(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Hemorrhagic preconditioning improves vascular reactivity after hemorrhagic_shock by activation of PKCa and PKC via the adenosine_A1_receptor in rats .
17329997	0	adenosine_A2A_receptor	27,49	ADORA2A	56,63	adenosine A2A receptor	ADORA2A	135	135	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A genetic variation in the adenosine_A2A_receptor gene -LRB- ADORA2A -RRB- contributes to individual sensitivity to caffeine effects on sleep .
12837758	0	adenosine_A2A_receptor	4,26	alpha-actinin	68,81	adenosine A2A receptor	alpha-actinin	135	87	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The adenosine_A2A_receptor interacts with the actin-binding protein alpha-actinin .
9029412	0	adenosine_A2a_receptor	6,28	A2aAR	30,35	adenosine A2a receptor	A2aAR	135	135	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human adenosine_A2a_receptor -LRB- A2aAR -RRB- gene : systematic mutation screening in patients with schizophrenia .
20716228	0	adenosine_A3_receptor	30,51	ADORA3	53,59	adenosine A3 receptor	ADORA3	140	140	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional variability of the adenosine_A3_receptor -LRB- ADORA3 -RRB- gene polymorphism in aspirin-induced_urticaria .
9293494	0	adenosine_A3_receptor	66,87	ADORA3	89,95	adenosine A3 receptor	ADORA3	140	140	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning , characterisation and chromosomal assignment of the human adenosine_A3_receptor -LRB- ADORA3 -RRB- gene .
22378888	0	adenosine_A3_receptor	20,41	CCL2	52,56	adenosine A3 receptor	CCL2	25370(Tax:10116)	24770(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	CXCL16 orchestrates adenosine_A3_receptor and MCP-1 / CCL2 activity to protect neurons from excitotoxic cell death in the CNS .
10200056	0	adenosine_deaminase	29,48	ADA	50,53	adenosine deaminase	ADA	100	100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Seven novel mutations in the adenosine_deaminase -LRB- ADA -RRB- gene in patients with severe and delayed onset combined_immunodeficiency : G74C , V129M , G140E , R149W , Q199P , 462delG , and E337del .
10853264	0	adenosine_deaminase	21,40	ADA	42,45	adenosine deaminase	ADA	11486(Tax:10090)	11486(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of murine adenosine_deaminase -LRB- ADA -RRB- in transgenic maize .
11860709	0	adenosine_deaminase	27,46	ADA	48,51	adenosine deaminase	ADA	100	100	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Flow cytometry analysis of adenosine_deaminase -LRB- ADA -RRB- expression : a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy .
17181544	0	adenosine_deaminase	48,67	ADA	69,72	adenosine deaminase	ADA	100	100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Carrier frequency of a nonsense mutation in the adenosine_deaminase -LRB- ADA -RRB- gene implies a high incidence of ADA-deficient severe_combined_immunodeficiency -LRB- SCID -RRB- in Somalia and a single , common haplotype indicates common ancestry .
17539288	0	adenosine_deaminase	22,41	ADA	43,46	adenosine deaminase	ADA	100	100	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Diagnostic utility of adenosine_deaminase -LRB- ADA -RRB- activity in pleural fluid and serum of tuberculous and non-tuberculous respiratory_disease patients .
2549545	0	adenosine_deaminase	57,76	ADA	78,81	adenosine deaminase	ADA	100	100	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Retroviral vector-mediated high-efficiency expression of adenosine_deaminase -LRB- ADA -RRB- in hematopoietic long-term cultures of ADA-deficient marrow cells .
2588953	0	adenosine_deaminase	16,35	ADA	37,40	adenosine deaminase	ADA	100	100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transfer of the adenosine_deaminase -LRB- ADA -RRB- gene of a B-lymphoblastoid cell line -LRB- LCL -RRB- to an ADA-deficient LCL by a microcell-mediated chromosome transfer technique .
26417242	0	adenosine_deaminase	14,33	ADA	35,38	adenosine deaminase	ADA	100	100	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of adenosine_deaminase -LRB- ADA -RRB- isoenzymes activity and tumor_necrosis_factor-a -LRB- TNFa -RRB- concentration in chronic heart_failure .
27017482	0	adenosine_deaminase	12,31	ADA	33,36	adenosine deaminase	ADA	100	100	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Can pleural adenosine_deaminase -LRB- ADA -RRB- levels in pleural_tuberculosis predict the presence of pulmonary_tuberculosis ?
3485513	0	adenosine_deaminase	58,77	ADA	84,87	adenosine deaminase	ADA	24165(Tax:10116)	24165(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosome_anomalies associated with amplification of the adenosine_deaminase gene -LRB- ADA -RRB- in rat hepatoma cells .
7655514	0	adenosine_deaminase	18,37	ADA	39,42	adenosine deaminase	ADA	100	100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of the adenosine_deaminase -LRB- ADA -RRB- gene using a dicistronic promoterless construct : production of an ADA-deficient homozygote ES cell line .
8031011	0	adenosine_deaminase	39,58	ADA	60,63	adenosine deaminase	ADA	100	100	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	An Asp8Asn substitution results in the adenosine_deaminase -LRB- ADA -RRB- genetic polymorphism -LRB- ADA_2 allozyme -RRB- : occurrence on different chromosomal backgrounds and apparent intragenic crossover .
9475605	0	adenosine_deaminase	27,46	ADA	48,51	adenosine deaminase	ADA	100	100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Visible integration of the adenosine_deaminase -LRB- ADA -RRB- gene into the recipient genome after gene therapy .
15670822	0	adenosine_deaminase	16,35	ADA2	0,4	adenosine deaminase	ADA2	100	51816	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	ADA2 isoform of adenosine_deaminase from pleural fluid .
9765260	0	adenosine_deaminase	48,67	AP-2gamma	21,30	adenosine deaminase	AP-2gamma	11486(Tax:10090)	21420(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor AP-2gamma regulates murine adenosine_deaminase gene expression during placental development .
7907293	0	adenosine_deaminase	11,30	CD26	61,65	adenosine deaminase	CD26	100	1803	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of adenosine_deaminase to the lymphocyte surface via CD26 .
8101391	0	adenosine_deaminase	22,41	CD26	76,80	adenosine deaminase	CD26	100	1803	Gene	Gene	association|nmod|START_ENTITY association|nmod|antigen antigen|appos|END_ENTITY	Direct association of adenosine_deaminase with a T cell activation antigen , CD26 .
8568233	0	adenosine_deaminase	20,39	CD26	57,61	adenosine deaminase	CD26	100	1803	Gene	Gene	cells|amod|START_ENTITY cells|amod|binding binding|nmod|END_ENTITY	Characterization of adenosine_deaminase binding to human CD26 on T cells and its biologic role in immune response .
9330696	0	adenosine_deaminase	47,66	CD26	84,88	adenosine deaminase	CD26	100	1803	Gene	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	HIV-1 envelope gp120 and viral particles block adenosine_deaminase binding to human CD26 .
12809673	0	adenosine_deaminase	45,64	ada	66,69	adenosine deaminase	ada	100	100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage disequilibrium analysis of the human adenosine_deaminase -LRB- ada -RRB- gene provides evidence for a lack of correlation between hot spots of equal and unequal homologous recombination .
1569204	0	adenosine_deaminase	54,73	adenosine_deaminase	91,110	adenosine deaminase	adenosine deaminase	100	100	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	IgG antibody response to polyethylene_glycol-modified adenosine_deaminase in patients with adenosine_deaminase deficiency .
1569204	0	adenosine_deaminase	91,110	adenosine_deaminase	54,73	adenosine deaminase	adenosine deaminase	100	100	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency END_ENTITY|nmod|patients	IgG antibody response to polyethylene_glycol-modified adenosine_deaminase in patients with adenosine_deaminase deficiency .
11067872	0	adenosine_deaminase	26,45	cd26	122,126	adenosine deaminase	cd26	100	1803	Gene	Gene	site|nmod|START_ENTITY site|parataxis|impairs impairs|xcomp|binding binding|nmod|END_ENTITY	The binding site of human adenosine_deaminase for CD26/Dipeptidyl _ peptidase_IV : the Arg142Gln mutation impairs binding to cd26 but does not cause immune_deficiency .
7594462	1	adenosine_deaminase	116,135	costimulatory_molecule	139,161	adenosine deaminase	costimulatory molecule	100	80381	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of adenosine_deaminase as costimulatory_molecule .
10583373	0	adenosine_deaminase	44,63	dipeptidyl_peptidase_IV	17,40	adenosine deaminase	dipeptidyl peptidase IV	100	1803	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding to human dipeptidyl_peptidase_IV by adenosine_deaminase and antibodies that inhibit ligand binding involves overlapping , discontinuous sites on a predicted beta propeller domain .
12009420	0	adenosine_deaminase	55,74	dipeptidyl_peptidase_IV	26,49	adenosine deaminase	dipeptidyl peptidase IV	100	1803	Gene	Gene	protein|amod|START_ENTITY =|ccomp|protein adenosine_deaminase|parataxis|= adenosine_deaminase|nmod|role role|nmod|END_ENTITY	On the regulatory role of dipeptidyl_peptidase_IV -LRB- = CD = adenosine_deaminase complexing protein -RRB- on adenosine_deaminase activity .
12009420	0	adenosine_deaminase	98,117	dipeptidyl_peptidase_IV	26,49	adenosine deaminase	dipeptidyl peptidase IV	100	1803	Gene	Gene	START_ENTITY|nmod|role role|nmod|END_ENTITY	On the regulatory role of dipeptidyl_peptidase_IV -LRB- = CD = adenosine_deaminase complexing protein -RRB- on adenosine_deaminase activity .
16929383	0	adenosine_deaminase	64,83	dipeptidyl_peptidase_IV	13,36	adenosine deaminase	dipeptidyl peptidase IV	280712(Tax:9913)	281122(Tax:9913)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of dipeptidyl_peptidase_IV on enzymatic properties of adenosine_deaminase .
3257147	0	adenosine_deaminase	74,93	interferon-alpha_A	32,50	adenosine deaminase	interferon-alpha A	100	3440	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Opposite effects of recombinant interferon-alpha_A and deoxycoformycin on adenosine_deaminase activity in the Daudi B lymphoblastoid cell line .
3338296	0	adenosine_deaminase	58,77	lysozyme	105,113	adenosine deaminase	lysozyme	100	4069	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Diagnostic value of simultaneous determination of pleural adenosine_deaminase and pleural lysozyme/serum lysozyme ratio in pleural_effusions .
7989831	0	adenosine_deaminase	6,25	superoxide_dismutase	36,56	adenosine deaminase	superoxide dismutase	100	6647	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Serum adenosine_deaminase and total superoxide_dismutase activities before and after surgical removal of cancerous laryngeal tissue .
23645737	0	adenosine_deaminase-like	13,37	ADAL	39,43	adenosine deaminase-like	ADAL	161823	161823	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Mutations in adenosine_deaminase-like -LRB- ADAL -RRB- protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219 .
12206153	0	adenosine_deaminase_2	24,45	ADA2	47,51	adenosine deaminase 2	ADA2	51816	51816	Gene	Gene	activity|nummod|START_ENTITY activity|compound|END_ENTITY	The usefulness of serum adenosine_deaminase_2 -LRB- ADA2 -RRB- activity in adults for the diagnosis of pulmonary_tuberculosis .
3146530	0	adenosine_diphosphate_ribosyl_transferase	26,67	ADPRT	69,74	adenosine diphosphate ribosyl transferase	ADPRT	142	142	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Hydrogen_peroxide induced adenosine_diphosphate_ribosyl_transferase -LRB- ADPRT -RRB- response in patients with inflammatory_bowel_disease .
12885418	0	adenosine_diphosphate_ribosylation_factor-1	46,89	membrane_bound	4,18	adenosine diphosphate ribosylation factor-1	membrane bound	375	19	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The membrane_bound N-terminal domain of human adenosine_diphosphate_ribosylation_factor-1 -LRB- ARF1 -RRB- .
2108672	0	adenosine_diphosphoribosyl_transferase	19,57	ADPRT	59,64	adenosine diphosphoribosyl transferase	ADPRT	142	142	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	The interaction of adenosine_diphosphoribosyl_transferase -LRB- ADPRT -RRB- with a cruciform DNA .
21133723	0	adenosine_triphosphate-binding_cassette_subfamily_B_member_1	14,74	ABCB1	76,81	adenosine triphosphate-binding cassette subfamily B member 1	ABCB1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Assessment of adenosine_triphosphate-binding_cassette_subfamily_B_member_1 -LRB- ABCB1 -RRB- mRNA expression in patients with de novo chronic_myelogenous_leukemia : the role of different cell types .
4221495	0	adenosinetriphosphatase	48,71	myosin	84,90	adenosinetriphosphatase	myosin	481	79784	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Age changes in content of sulfhydryl groups and adenosinetriphosphatase activity of myosin .
6225457	0	adenosinetriphosphatase	13,36	myosin	68,74	adenosinetriphosphatase	myosin	481	79784	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Mechanism of adenosinetriphosphatase activity of trinitrophenylated myosin subfragment 1 .
6457630	0	adenosinetriphosphatase	72,95	myosin	104,110	adenosinetriphosphatase	myosin	481	79784	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Excitation energy transfer studies on the proximity between SH1 and the adenosinetriphosphatase site in myosin subfragment 1 .
9696808	0	adenovirus_type_5	41,58	orf4	19,23	adenovirus type 5	orf4	8081	83992	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	The early region 4 orf4 protein of human adenovirus_type_5 induces p53-independent cell death by apoptosis .
11968092	0	adenylate_cyclase_activating_polypeptide_1	59,101	ADCYAP1	103,110	adenylate cyclase activating polypeptide 1	ADCYAP1	116	116	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation screening and association studies of the adenylate_cyclase_activating_polypeptide_1 -LRB- ADCYAP1 -RRB- gene in patients with type 2 diabetes .
25202675	0	adenylate_kinase_locus_1	11,35	ak_1	37,41	adenylate kinase locus 1	ak 1	203	203	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	A study of adenylate_kinase_locus_1 -LRB- ak_1 -RRB- genetic polymorphism in diabetic_pregnancy .
9812171	0	adenylosuccinate_lyase	26,48	ASL	50,53	adenylosuccinate lyase	ASL	158	158	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Determination of p185 and adenylosuccinate_lyase -LRB- ASL -RRB- activity in preneoplastic colon_lesions and intestinal mucosa of human subjects .
15026181	0	adenylyl_cyclase-4	14,32	AC-4	34,38	adenylyl cyclase-4	AC-4	104110(Tax:10090)	104110(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of adenylyl_cyclase-4 -LRB- AC-4 -RRB- in Y1 and forskolin-resistant adrenal cells .
26992697	0	adenylyl_cyclase_1	61,79	TrkB	17,21	adenylyl cyclase 1	TrkB	432530(Tax:10090)	18212(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl_cyclase_1 and 8 knockout mice in a model of fetal alcohol_spectrum_disorder .
22613711	0	adenylyl_cyclase_8	73,91	AC8	93,96	adenylyl cyclase 8	AC8	29241(Tax:10116)	29241(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The Notch pathway attenuates interleukin_1b -LRB- IL1b -RRB- - mediated induction of adenylyl_cyclase_8 -LRB- AC8 -RRB- expression during vascular smooth muscle cell -LRB- VSMC -RRB- trans-differentiation .
24481586	0	adherens_junction-associated_protein_1	4,42	MAGEA2	86,92	adherens junction-associated protein 1	MAGEA2	55966	4101	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The adherens_junction-associated_protein_1 is a negative transcriptional regulator of MAGEA2 , which potentiates temozolomide-induced apoptosis in GBM .
1699290	0	adhesion_molecule_on_glia	20,45	Amog	14,18	adhesion molecule on glia	Amog	11932(Tax:10090)	11932(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of Amog -LRB- adhesion_molecule_on_glia -RRB- gene to mouse chromosome 11 near Zfp-3 and Asgr-1 ,2 and to human chromosome 17 .
9973250	0	adhesion_related_kinase	37,60	extracellular_signal-regulated_kinase	139,176	adhesion related kinase	extracellular signal-regulated kinase	26362(Tax:10090)	26413(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|nmod|END_ENTITY	Growth_arrest-specific_gene_6 -LRB- Gas6 -RRB- / adhesion_related_kinase -LRB- Ark -RRB- signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular_signal-regulated_kinase -LRB- ERK -RRB- and Akt .
15314084	0	adipocyte-derived_leucine_aminopeptidase	16,56	A-LAP	58,63	adipocyte-derived leucine aminopeptidase	A-LAP	51752	51752	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of adipocyte-derived_leucine_aminopeptidase -LRB- A-LAP -RRB- / ER-aminopeptidase _ -LRB- ERAP -RRB- -1 in human uterine endometrium .
11857741	0	adipocyte-derived_leucine_aminopeptidase	42,82	ALAP	84,88	adipocyte-derived leucine aminopeptidase	ALAP	51752	51752	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of 33 polymorphisms in the adipocyte-derived_leucine_aminopeptidase -LRB- ALAP -RRB- gene and possible association with hypertension .
15741767	0	adipocyte-derived_leucine_aminopeptidase	24,64	angiotensin_II	69,83	adipocyte-derived leucine aminopeptidase	angiotensin II	51752	183	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of adipocyte-derived_leucine_aminopeptidase via angiotensin_II in endometrial_carcinoma .
19217286	0	adipocyte_fatty-acid_binding_protein	79,115	A-FABP	117,123	adipocyte fatty-acid binding protein	A-FABP	2167	2167	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	N-Benzyl-indolo_carboxylic_acids : Design and synthesis of potent and selective adipocyte_fatty-acid_binding_protein -LRB- A-FABP -RRB- inhibitors .
16324920	0	adiponectin	34,45	ACDC	47,51	adiponectin	ACDC	9370	9370	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The SNP276G > T polymorphism in the adiponectin -LRB- ACDC -RRB- gene is more strongly associated with insulin resistance and cardiovascular_disease risk than SNP45T > G in nonobese/nondiabetic Korean men independent of abdominal adiposity and circulating plasma adiponectin .
18776141	0	adiponectin	23,34	ADIPOQ	41,47	adiponectin	ADIPOQ	9370	9370	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Common variants in the adiponectin gene -LRB- ADIPOQ -RRB- associated with plasma adiponectin levels , type 2 diabetes , and diabetes-related quantitative traits : the Framingham Offspring Study .
19178518	0	adiponectin	22,33	ADIPOQ	35,41	adiponectin	ADIPOQ	9370	9370	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutation in the adiponectin -LRB- ADIPOQ -RRB- gene is associated with hypoadiponectinaemia in Japanese-Brazilians .
21619462	0	adiponectin	12,23	ADIPOQ	25,31	adiponectin	ADIPOQ	9370	9370	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The role of adiponectin -LRB- ADIPOQ -RRB- gene polymorphisms in the susceptibility and prognosis of non-small_cell_lung_cancer .
24528335	0	adiponectin	15,26	ADIPOQ	28,34	adiponectin	ADIPOQ	9370	9370	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of adiponectin -LRB- ADIPOQ -RRB- rs2241766 polymorphism and dyslipidemia in HIV/HCV-coinfected patients .
17716299	0	adiponectin	17,28	ADIPOR1	44,51	adiponectin	ADIPOR1	9370	51094	Gene	Gene	genes|amod|START_ENTITY Polymorphisms|nmod|genes Polymorphisms|dep|END_ENTITY	Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance .
18455514	0	adiponectin	22,33	AMPK	44,48	adiponectin	AMPK	9370	5563	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells .
20649096	0	adiponectin	34,45	AMPK	58,62	adiponectin	AMPK	9370	5562	Gene	Gene	Pro-insulin|appos|START_ENTITY Pro-insulin|appos|END_ENTITY	Pro-insulin , _ C_peptide , glucagon , adiponectin , TNF_alpha , AMPK : neglected players in type_2_diabetes_mellitus .
24104889	0	adiponectin	10,21	AMPK	24,28	adiponectin	AMPK	9370	5563	Gene	Gene	START_ENTITY|dep|system system|compound|END_ENTITY	Disturbed adiponectin - AMPK system in skeletal muscle of patients with metabolic_syndrome .
26363472	0	adiponectin	9,20	AMPKa2	80,86	adiponectin	AMPKa2	9370	5563	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Globular adiponectin controls insulin-mediated vasoreactivity in muscle through AMPKa2 .
25966186	0	adiponectin	41,52	APM-1	59,64	adiponectin	APM-1	9370	9370	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between polymorphisms in the adiponectin gene -LRB- APM-1 -RRB- and atherosclerotic_cerebral_infarction in a Hainan Chinese Han population .
14749263	0	adiponectin	71,82	APM1	84,88	adiponectin	APM1	9370	9370	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in the proximal promoter region of the adiponectin -LRB- APM1 -RRB- gene are associated with type 2 diabetes in Swedish caucasians .
19263799	0	adiponectin	69,80	APM1	82,86	adiponectin	APM1	9370	9370	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a regulatory single nucleotide polymorphism in the adiponectin -LRB- APM1 -RRB- gene associated with type 2 diabetes in Han nationality .
21254618	0	adiponectin	46,57	APM1	59,63	adiponectin	APM1	9370	9370	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Single nucleotide polymorphism of +276 _ g _ > _ t adiponectin -LRB- APM1 -RRB- gene in donors of Kharkiv population -RSB- .
19661063	0	adiponectin	23,34	APPL	48,52	adiponectin	APPL	9370	26060	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells .
18854421	0	adiponectin	15,26	APPL1	0,5	adiponectin	APPL1	9370	26060	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	APPL1 : role in adiponectin signaling and beyond .
19638541	0	adiponectin	18,29	Adipo-R1	40,48	adiponectin	Adipo-R1	9370	51094	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	The expression of adiponectin receptors Adipo-R1 and Adipo-R2 is associated with an intestinal histotype and longer survival in gastric_carcinoma .
18394428	0	adiponectin	69,80	AdipoR1	0,7	adiponectin	AdipoR1	9370	51094	Gene	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|END_ENTITY	AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus .
18695895	0	adiponectin	14,25	AdipoR1	37,44	adiponectin	AdipoR1	9370	51094	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Expression of adiponectin receptors , AdipoR1 and AdipoR2 , in normal colon epithelium and colon_cancer tissue .
25582653	0	adiponectin	50,61	AdipoR1	14,21	adiponectin	AdipoR1	9370	51094	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|levels levels|amod|END_ENTITY	Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary_artery_disease patients ?
25892445	0	adiponectin	24,35	AdipoR1	120,127	adiponectin	AdipoR1	9370	51094	Gene	Gene	receptors|compound|START_ENTITY Characterisation|nmod|receptors Characterisation|dep|Differential Differential|acl:relcl|regulated regulated|nsubjpass|expression expression|nmod|END_ENTITY	Characterisation of the adiponectin receptors : Differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks .
26251033	0	adiponectin	45,56	AdipoR1	76,83	adiponectin	AdipoR1	9370	51094	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Molecular cloning and expression analysis of adiponectin and its receptors -LRB- AdipoR1 and AdipoR2 -RRB- in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle .
26251033	0	adiponectin	45,56	AdipoR1	76,83	adiponectin	AdipoR1	9370	51094	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Molecular cloning and expression analysis of adiponectin and its receptors -LRB- AdipoR1 and AdipoR2 -RRB- in the hypothalamus of the Huoyan goose during different stages of the egg-laying cycle .
26453924	0	adiponectin	41,52	AdipoR1	91,98	adiponectin	AdipoR1	9370	51094	Gene	Gene	function|compound|START_ENTITY function|nmod|inhibition inhibition|nmod|formation formation|compound|END_ENTITY	High glucose/High Lipids impair vascular adiponectin function via inhibition of caveolin-1 / AdipoR1 signalsome formation .
17213280	0	adiponectin	72,83	Adiponectin	0,11	adiponectin	Adiponectin	9370	9370	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus .
18363889	0	adiponectin	29,40	Adiponectin	0,11	adiponectin	Adiponectin	9370	9370	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Adiponectin , skeletal muscle adiponectin receptor expression and insulin resistance following dexamethasone .
22340319	0	adiponectin	50,61	Adiponectin_receptor_1	0,22	adiponectin	Adiponectin receptor 1	9370	51094	Gene	Gene	fibroblasts|amod|START_ENTITY difference|nmod|fibroblasts mediates|dobj|difference mediates|nsubj|END_ENTITY	Adiponectin_receptor_1 mediates the difference in adiponectin - induced prostaglandin_E2 production in rheumatoid_arthritis and osteoarthritis synovial fibroblasts .
23050488	0	adiponectin	9,20	Akt	78,81	adiponectin	Akt	9370	207	Gene	Gene	protects|nsubj|START_ENTITY protects|advcl|signaling signaling|nsubj|apoptosis apoptosis|nmod|END_ENTITY	Globular adiponectin protects H9c2 cells from palmitate-induced apoptosis via Akt and ERK1/2 signaling pathways .
24582693	0	adiponectin	42,53	Atg5	14,18	adiponectin	Atg5	9370	9474	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of Atg5 expression by globular adiponectin contributes to autophagy flux and suppression of ethanol-induced cell death in liver cells .
23207119	0	adiponectin	14,25	B-type_natriuretic_peptide	59,85	adiponectin	B-type natriuretic peptide	9370	4879	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Total and HMW adiponectin is independently associated with B-type_natriuretic_peptide and anemia in chronic_hemodialysis patients .
12578865	0	adiponectin	50,61	C-reactive_protein	26,44	adiponectin	C-reactive protein	9370	1401	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Reciprocal association of C-reactive_protein with adiponectin in blood stream and adipose tissue .
16188522	0	adiponectin	32,43	C-reactive_protein	58,76	adiponectin	C-reactive protein	9370	1401	Gene	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	Relation of microalbuminuria to adiponectin and augmented C-reactive_protein levels in men with essential hypertension .
17641277	0	adiponectin	28,39	C-reactive_protein	0,18	adiponectin	C-reactive protein	9370	1401	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	C-reactive_protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes .
18362454	0	adiponectin	66,77	C-reactive_protein	15,33	adiponectin	C-reactive protein	9370	1401	Gene	Gene	reflects|nsubj|START_ENTITY Combination|parataxis|reflects Combination|nmod|weight weight|amod|END_ENTITY	Combination of C-reactive_protein and high molecular weight -LRB- HMW -RRB- - adiponectin reflects further metabolic_abnormalities compared with each of them alone in Japanese type 2 diabetic subjects .
25137264	0	adiponectin	60,71	C-reactive_protein	40,58	adiponectin	C-reactive protein	9370	1401	Gene	Gene	START_ENTITY|nsubj|Association Association|appos|END_ENTITY	Association between nutritional status , C-reactive_protein , adiponectin and HOMA-AD in Brazilian children .
15919796	0	adiponectin	27,38	C/EBPalpha	0,10	adiponectin	C/EBPalpha	9370	1050	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer .
19282610	0	adiponectin	34,45	CD40_ligand	58,69	adiponectin	CD40 ligand	9370	959	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Effect of cilostazol treatment on adiponectin and soluble CD40_ligand levels in diabetic patients with peripheral arterial_occlusion_disease .
21872196	0	adiponectin	32,43	CDH13	26,31	adiponectin	CDH13	9370	1012	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	A variant upstream of the CDH13 adiponectin receptor gene and metabolic_syndrome in Swedes .
24041676	0	adiponectin	62,73	CDH13	0,5	adiponectin	CDH13	9370	1012	Gene	Gene	association|nmod|START_ENTITY association|nummod|END_ENTITY	CDH13 genotype-dependent association of high-molecular weight adiponectin with all-cause mortality : the J-SHIPP study .
16682005	0	adiponectin	22,33	Endothelin-1	0,12	adiponectin	Endothelin-1	9370	1906	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol_4 ,5 - bisphosphate/actin-dependent mechanism .
17194742	0	adiponectin	23,34	Endothelin-1	0,12	adiponectin	Endothelin-1	9370	1906	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Endothelin-1 regulates adiponectin gene expression and secretion in 3T3-L1 adipocytes via distinct signaling pathways .
18466765	0	adiponectin	9,20	GnRH	30,34	adiponectin	GnRH	9370	2796	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|secretion secretion|compound|END_ENTITY	Globular adiponectin inhibits GnRH secretion from GT1-7 hypothalamic GnRH neurons by induction of hyperpolarization of membrane potential .
18031314	0	adiponectin	9,20	IGFBP-1	22,29	adiponectin	IGFBP-1	9370	3484	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	Insulin , adiponectin , IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages .
24434628	0	adiponectin	12,23	IL-6	45,49	adiponectin	IL-6	9370	3569	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	The role of adiponectin in the production of IL-6 , IL-8 , VEGF and MMPs in human endothelial cells and osteoblasts : implications for arthritic_joints .
16039610	0	adiponectin	14,25	IL-8	29,33	adiponectin	IL-8	9370	3576	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells .
12660877	0	adiponectin	24,35	Insulin	0,7	adiponectin	Insulin	9370	3630	Gene	Gene	levels|compound|START_ENTITY decreases|dobj|levels decreases|nsubj|END_ENTITY	Insulin decreases human adiponectin plasma levels .
18031314	0	adiponectin	9,20	Insulin	0,7	adiponectin	Insulin	9370	3630	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Insulin , adiponectin , IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages .
18208577	0	adiponectin	38,49	Insulin	0,7	adiponectin	Insulin	9370	3630	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression effect|compound|END_ENTITY	Insulin effect on adipose_tissue -LRB- AT -RRB- adiponectin expression is regulated by the insulin resistance status of the patients .
21156037	0	adiponectin	20,31	Insulin	0,7	adiponectin	Insulin	9370	3630	Gene	Gene	outcomes|compound|START_ENTITY outcomes|compound|END_ENTITY	Insulin resistance , adiponectin and adverse outcomes following elective cardiac surgery : a prospective follow-up study .
23431015	0	adiponectin	22,33	Insulin	0,7	adiponectin	Insulin	9370	3630	Gene	Gene	deficiency|compound|START_ENTITY resistance|nmod|deficiency resistance|compound|END_ENTITY	Insulin resistance by adiponectin deficiency : is the action in skeletal muscle ?
24973036	0	adiponectin	67,78	Insulin	0,7	adiponectin	Insulin	9370	3630	Gene	Gene	START_ENTITY|nsubj|resistance resistance|compound|END_ENTITY	Insulin resistance and its relationship with high molecular weight adiponectin in adolescents with polycystic_ovary_syndrome and a maternal history of polycystic_ovary_syndrome .
25286962	0	adiponectin	61,72	Insulin	0,7	adiponectin	Insulin	9370	3630	Gene	Gene	relation|nmod|START_ENTITY resistance|dep|relation resistance|compound|END_ENTITY	Insulin resistance in patients on valproic_acid : relation to adiponectin .
17652887	0	adiponectin	31,42	Interleukin-10	0,14	adiponectin	Interleukin-10	9370	3586	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Interleukin-10 associates with adiponectin predominantly in subjects with metabolic_syndrome .
18086672	0	adiponectin	26,37	Interleukin-18	0,14	adiponectin	Interleukin-18	9370	3606	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation .
15126241	0	adiponectin	43,54	Leptin	0,6	adiponectin	Leptin	11450(Tax:10090)	16846(Tax:10090)	Gene	Gene	increased|dobj|START_ENTITY increased|nsubj|markedly markedly|compound|END_ENTITY	Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice .
17823381	0	adiponectin	7,18	Leptin	0,6	adiponectin	Leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY predictor|nsubj|ratio END_ENTITY|parataxis|predictor	Leptin : adiponectin ratio is an independent predictor of intima_media_thickness of the common carotid artery .
19441676	0	adiponectin	11,22	Leptin	1,7	adiponectin	Leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	-LSB- Leptin to adiponectin ratio , as an index of insulin resistance and atherosclerosis development -RSB- .
19855365	0	adiponectin	31,42	Leptin	0,6	adiponectin	Leptin	9370	3952	Gene	Gene	leptin|xcomp|START_ENTITY leptin|nsubj|END_ENTITY	Leptin , adiponectin , leptin to adiponectin ratio and insulin resistance in depressive women .
21779189	0	adiponectin	7,18	Leptin	0,6	adiponectin	Leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Leptin : adiponectin ratio and metabolic_syndrome in the general Japanese population .
21951069	0	adiponectin	8,19	Leptin	0,6	adiponectin	Leptin	9370	3952	Gene	Gene	adipokines_in_gestational_diabetes_mellitus|compound|START_ENTITY END_ENTITY|appos|adipokines_in_gestational_diabetes_mellitus	Leptin , adiponectin and other adipokines_in_gestational_diabetes_mellitus and pre-eclampsia .
23066861	0	adiponectin	10,21	Leptin	0,6	adiponectin	Leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Leptin to adiponectin ratio as a useful predictor for cardiac_syndrome_X .
23923407	0	adiponectin	10,21	Leptin	0,6	adiponectin	Leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Leptin to adiponectin ratio in preeclampsia .
25622736	0	adiponectin	9,20	Leptin	1,7	adiponectin	Leptin	9370	3952	Gene	Gene	hormone|compound|START_ENTITY END_ENTITY|appos|hormone	-LSB- Leptin , adiponectin and sex hormone in benign_acanthosis_nigricans of males -RSB- .
26020766	0	adiponectin	23,34	MicroRNA-193b	0,13	adiponectin	MicroRNA-193b	9370	574455	Gene	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	MicroRNA-193b controls adiponectin production in human white_adipose_tissue .
18537100	0	adiponectin	148,159	NF-kappaB	20,29	adiponectin	NF-kappaB	9370	4790	Gene	Gene	leads|dobj|START_ENTITY activation|acl:relcl|leads activation|amod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	adiponectin	148,159	NF-kappaB	87,96	adiponectin	NF-kappaB	9370	4790	Gene	Gene	leads|dobj|START_ENTITY leads|nmod|suppression suppression|nmod|activation activation|amod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	adiponectin	186,197	NF-kappaB	20,29	adiponectin	NF-kappaB	9370	4790	Gene	Gene	adiponectin|nmod|START_ENTITY leads|dobj|adiponectin activation|acl:relcl|leads activation|amod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
18537100	0	adiponectin	186,197	NF-kappaB	87,96	adiponectin	NF-kappaB	9370	4790	Gene	Gene	adiponectin|nmod|START_ENTITY leads|dobj|adiponectin leads|nmod|suppression suppression|nmod|activation activation|amod|END_ENTITY	Adiponectin induces NF-kappaB activation that leads to suppression of cytokine-induced NF-kappaB activation in vascular endothelial cells : globular adiponectin vs. high molecular weight adiponectin .
17081797	0	adiponectin	23,34	Oncostatin_M	0,12	adiponectin	Oncostatin M	9370	5008	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Oncostatin_M decreases adiponectin expression and induces dedifferentiation of adipocytes by JAK3 - and MEK-dependent pathways .
20484463	0	adiponectin	59,70	Peroxisome_proliferator-activated_receptor-gamma	0,48	adiponectin	Peroxisome proliferator-activated receptor-gamma	9370	5468	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44 .
16849835	0	adiponectin	64,75	Prolactin	45,54	adiponectin	Prolactin	9370	5617	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Hypoadiponectinemia in lean lactating women : Prolactin inhibits adiponectin secretion from human adipocytes .
23975745	0	adiponectin	76,87	Resistin	0,8	adiponectin	Resistin	9370	56729	Gene	Gene	modification|nmod|START_ENTITY END_ENTITY|dep|modification	Resistin and all-cause and cardiovascular mortality : effect modification by adiponectin in end-stage_kidney_disease patients .
27079485	0	adiponectin	53,64	Resistin	0,8	adiponectin	Resistin	9370	56729	Gene	Gene	ratio|compound|START_ENTITY predictor|nsubj|ratio predictor|parataxis|predictor predictor|nsubj|END_ENTITY	Resistin is a predictor of asthma risk and resistin : adiponectin ratio is a negative predictor of lung function in asthma .
22595290	0	adiponectin	46,57	Snail	0,5	adiponectin	Snail	9370	6615	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Snail , a transcriptional regulator , represses adiponectin expression by directly binding to an E-box motif in the promoter .
16273386	0	adiponectin	3,14	T-cadherin	164,174	adiponectin	T-cadherin	9370	1012	Gene	Gene	receptor|compound|START_ENTITY expressed|nsubjpass|receptor expressed|nmod|cells cells|dep|talk talk|nmod|pathways pathways|amod|END_ENTITY	An adiponectin receptor , T-cadherin , was selectively expressed in intratumoral capillary endothelial cells in hepatocellular_carcinoma : possible cross talk between T-cadherin and FGF-2 pathways .
16273386	0	adiponectin	3,14	T-cadherin	25,35	adiponectin	T-cadherin	9370	1012	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	An adiponectin receptor , T-cadherin , was selectively expressed in intratumoral capillary endothelial cells in hepatocellular_carcinoma : possible cross talk between T-cadherin and FGF-2 pathways .
22065538	0	adiponectin	61,72	T-cadherin	18,28	adiponectin	T-cadherin	9370	1012	Gene	Gene	levels|compound|START_ENTITY variations|nmod|levels influences|dobj|variations influences|nsubj|END_ENTITY	CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population .
12876073	0	adiponectin	84,95	TNF-alpha	24,33	adiponectin	TNF-alpha	9370	7124	Gene	Gene	expression|compound|START_ENTITY implications|nmod|expression expression|dep|implications expression|nmod|END_ENTITY	Increased expression of TNF-alpha , IL-6 , and IL-8 in HALS : implications for reduced adiponectin expression and plasma levels .
15629137	0	adiponectin	58,69	TNF-alpha	84,93	adiponectin	TNF-alpha	9370	7124	Gene	Gene	expression|compound|START_ENTITY suppression|nmod|expression involved|nmod|suppression involved|nmod|END_ENTITY	c-Jun_N-terminal_kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes .
17537727	0	adiponectin	50,61	TNF-alpha	101,110	adiponectin	TNF-alpha	9370	7124	Gene	Gene	macrophages|nmod|START_ENTITY treatment|nmod|macrophages increases|nsubj|treatment increases|dobj|expression expression|appos|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
17537727	0	adiponectin	50,61	TNF-alpha	175,184	adiponectin	TNF-alpha	9370	7124	Gene	Gene	macrophages|nmod|START_ENTITY treatment|nmod|macrophages increases|nsubj|treatment increases|dobj|expression expression|nmod|activation activation|dep|role role|nmod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
18577375	0	adiponectin	94,105	TNF-alpha	57,66	adiponectin	TNF-alpha	9370	7124	Gene	Gene	expression|compound|START_ENTITY downregulation|nmod|expression downregulation|amod|END_ENTITY	6-Shogaol and 6-gingerol , the pungent of ginger , inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes .
25888509	0	adiponectin	96,107	TNF-alpha	0,9	adiponectin	TNF-alpha	11450(Tax:10090)	21926(Tax:10090)	Gene	Gene	upregulating|dobj|START_ENTITY ameliorates|advcl|upregulating ameliorates|nsubj|antagonism antagonism|amod|END_ENTITY	TNF-alpha antagonism ameliorates myocardial_ischemia / reperfusion injury in mice by upregulating adiponectin .
25888509	0	adiponectin	96,107	TNF-alpha	0,9	adiponectin	TNF-alpha	11450(Tax:10090)	21926(Tax:10090)	Gene	Gene	upregulating|dobj|START_ENTITY ameliorates|advcl|upregulating ameliorates|nsubj|antagonism antagonism|amod|END_ENTITY	TNF-alpha antagonism ameliorates myocardial_ischemia / reperfusion injury in mice by upregulating adiponectin .
26407855	0	adiponectin	37,48	TNF-alpha	66,75	adiponectin	TNF-alpha	9370	7124	Gene	Gene	multimerization|nmod|START_ENTITY regulated|nsubjpass|multimerization regulated|nmod|END_ENTITY	The multimerization and secretion of adiponectin are regulated by TNF-alpha .
20649096	0	adiponectin	34,45	TNF_alpha	47,56	adiponectin	TNF alpha	9370	7124	Gene	Gene	Pro-insulin|appos|START_ENTITY Pro-insulin|appos|END_ENTITY	Pro-insulin , _ C_peptide , glucagon , adiponectin , TNF_alpha , AMPK : neglected players in type_2_diabetes_mellitus .
23700519	0	adiponectin	121,132	Uncoupling_protein-2	0,20	adiponectin	Uncoupling protein-2	9370	7351	Gene	Gene	Relationship|nmod|START_ENTITY END_ENTITY|dep|Relationship	Uncoupling_protein-2 -LRB- UCP2 -RRB- gene expression in subcutaneous and omental adipose tissue of Asian Indians : Relationship to adiponectin and parameters of metabolic_syndrome .
16551730	0	adiponectin	12,23	adiponectin	42,53	adiponectin	adiponectin	9370	9370	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle : associations with metabolic parameters and insulin resistance and regulation by physical training .
16551730	0	adiponectin	42,53	adiponectin	12,23	adiponectin	adiponectin	9370	9370	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle : associations with metabolic parameters and insulin resistance and regulation by physical training .
16804063	0	adiponectin	48,59	adiponectin	71,82	adiponectin	adiponectin	9370	9370	Gene	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Comparison of serum high-molecular weight -LRB- HMW -RRB- adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary_artery_disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin .
16804063	0	adiponectin	71,82	adiponectin	48,59	adiponectin	adiponectin	9370	9370	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	Comparison of serum high-molecular weight -LRB- HMW -RRB- adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary_artery_disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin .
17135604	0	adiponectin	27,38	adiponectin	67,78	adiponectin	adiponectin	9370	9370	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals .
17135604	0	adiponectin	67,78	adiponectin	27,38	adiponectin	adiponectin	9370	9370	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of adiponectin receptor gene expression by adiponectin and leptin in myotubes derived from obese and diabetic individuals .
17608265	0	adiponectin	19,30	adiponectin	32,43	adiponectin	adiponectin	9370	9370	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Relationship among adiponectin , adiponectin gene expression and fatty_acids composition in morbidly obese patients .
17608265	0	adiponectin	32,43	adiponectin	19,30	adiponectin	adiponectin	9370	9370	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Relationship among adiponectin , adiponectin gene expression and fatty_acids composition in morbidly obese patients .
18972601	0	adiponectin	18,29	adiponectin	59,70	adiponectin	adiponectin	9370	9370	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|nmod|END_ENTITY	The expression of adiponectin receptors and the effects of adiponectin and leptin on airway_smooth_muscle cells .
18972601	0	adiponectin	59,70	adiponectin	18,29	adiponectin	adiponectin	9370	9370	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	The expression of adiponectin receptors and the effects of adiponectin and leptin on airway_smooth_muscle cells .
23006813	0	adiponectin	111,122	adiponectin	21,32	adiponectin	adiponectin	9370	9370	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Low-molecular-weight adiponectin is more closely associated with episodes of asthma than high-molecular-weight adiponectin .
23006813	0	adiponectin	21,32	adiponectin	111,122	adiponectin	adiponectin	9370	9370	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Low-molecular-weight adiponectin is more closely associated with episodes of asthma than high-molecular-weight adiponectin .
25909078	0	adiponectin	31,42	adiponectin	77,88	adiponectin	adiponectin	9370	9370	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	The association of circulating adiponectin and + ___ 45 __ T/G polymorphism of adiponectin gene with gestational_diabetes_mellitus in Iranian population .
25909078	0	adiponectin	77,88	adiponectin	31,42	adiponectin	adiponectin	9370	9370	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	The association of circulating adiponectin and + ___ 45 __ T/G polymorphism of adiponectin gene with gestational_diabetes_mellitus in Iranian population .
20208458	0	adiponectin	28,39	apelin	41,47	adiponectin	apelin	9370	8862	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Relationships between serum adiponectin , apelin , leptin , resistin , visfatin levels and bone_mineral_density , and bone biochemical markers in post-menopausal Chinese women .
18712036	0	adiponectin	7,18	brain_natriuretic_peptide	45,70	adiponectin	brain natriuretic peptide	9370	4879	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Plasma adiponectin is associated with plasma brain_natriuretic_peptide and cardiac function in healthy subjects .
25483913	0	adiponectin	75,86	endocan	108,115	adiponectin	endocan	9370	11082	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Increased expression of endocan in arthritic synovial tissues : Effects of adiponectin on the expression of endocan in fibroblast-like synoviocytes .
25483913	0	adiponectin	75,86	endocan	24,31	adiponectin	endocan	9370	11082	Gene	Gene	Effects|nmod|START_ENTITY expression|dep|Effects expression|nmod|END_ENTITY	Increased expression of endocan in arthritic synovial tissues : Effects of adiponectin on the expression of endocan in fibroblast-like synoviocytes .
14651962	0	adiponectin	14,25	endothelin-1	39,51	adiponectin	endothelin-1	9370	1906	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|advcl|END_ENTITY	Regulation of adiponectin secretion by endothelin-1 .
17003095	0	adiponectin	42,53	growth_hormone	10,24	adiponectin	growth hormone	9370	2688	Gene	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Effect of growth_hormone therapy on serum adiponectin and resistin levels in short , small-for-gestational-age children and associations with cardiovascular risk parameters .
20061428	0	adiponectin	15,26	growth_hormone	89,103	adiponectin	growth hormone	9370	2688	Gene	Gene	expression|compound|START_ENTITY Correlation|nmod|expression Correlation|nmod|END_ENTITY	Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth_hormone -LRB- GH -RRB- - treated children with Prader-Willi_syndrome and in non-GH-treated obese children .
12827242	0	adiponectin	21,32	insulin	75,82	adiponectin	insulin	9370	3630	Gene	Gene	epistasis|nmod|START_ENTITY genotypes|nsubj|epistasis genotypes|nmod|modulation modulation|nmod|sensitivity sensitivity|compound|END_ENTITY	Genetic epistasis of adiponectin and PPARgamma2 genotypes in modulation of insulin sensitivity : a family-based association study .
15579191	0	adiponectin	16,27	insulin	39,46	adiponectin	insulin	9370	3630	Gene	Gene	level|compound|START_ENTITY Correlations|nmod|level Correlations|nmod|resistance resistance|compound|END_ENTITY	Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations .
15698395	0	adiponectin	16,27	insulin	98,105	adiponectin	insulin	9370	3630	Gene	Gene	concentrations|compound|START_ENTITY correlate|nsubj|concentrations correlate|nmod|levels levels|compound|END_ENTITY	Elevated plasma adiponectin concentrations in patients with liver_cirrhosis correlate with plasma insulin levels .
15734858	0	adiponectin	70,81	insulin	83,90	adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|appos|resistance resistance|compound|END_ENTITY	Adipocytokines and VLDL metabolism : independent regulatory effects of adiponectin , insulin resistance , and fat compartments on VLDL apolipoprotein_B-100 kinetics ?
15824752	0	adiponectin	81,92	insulin	48,55	adiponectin	insulin	9370	3630	Gene	Gene	role|nmod|START_ENTITY mass|dep|role mass|nmod|marker marker|nmod|sensitivity sensitivity|compound|END_ENTITY	Lower-body fat mass as an independent marker of insulin sensitivity -- the role of adiponectin .
15862282	0	adiponectin	159,170	insulin	199,206	adiponectin	insulin	9370	3630	Gene	Gene	independent|compound|START_ENTITY independent|nmod|indices indices|compound|END_ENTITY	Adiponectin and resistin serum levels in women with polycystic_ovary_syndrome during oral glucose tolerance test : a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices .
16285470	0	adiponectin	34,45	insulin	60,67	adiponectin	insulin	9370	3630	Gene	Gene	background|nmod|START_ENTITY background|nmod|resistance resistance|compound|END_ENTITY	Biological background and role of adiponectin as marker for insulin resistance and cardiovascular risk .
16498821	0	adiponectin	13,24	insulin	44,51	adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|nmod|pathogenesis pathogenesis|nmod|resistance resistance|compound|END_ENTITY	-LSB- The role of adiponectin in pathogenesis of insulin resistance and metabolic_syndrome -RSB- .
16571847	0	adiponectin	16,27	insulin	33,40	adiponectin	insulin	9370	3630	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|nmod|sensitivity sensitivity|compound|END_ENTITY	Relationship of adiponectin with insulin sensitivity in humans , independent of lipid availability .
16624648	0	adiponectin	52,63	insulin	43,50	adiponectin	insulin	9370	3630	Gene	Gene	and_insulin-like_growth_factor-I|dep|START_ENTITY and_insulin-like_growth_factor-I|compound|END_ENTITY	Body fat at birth and cord blood levels of insulin , adiponectin , leptin , _ and_insulin-like_growth_factor-I in small-for-gestational-age infants .
16814726	0	adiponectin	34,45	insulin	56,63	adiponectin	insulin	9370	3630	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|action action|compound|END_ENTITY	APPLied mechanics : uncovering how adiponectin modulates insulin action .
17038635	0	adiponectin	7,18	insulin	87,94	adiponectin	insulin	9370	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|resistance resistance|compound|END_ENTITY	Plasma adiponectin levels in relation to carotid intima_media_thickness and markers of insulin resistance .
17264850	0	adiponectin	16,27	insulin	133,140	adiponectin	insulin	9370	3630	Gene	Gene	Associations|nmod|START_ENTITY reveal|nsubj|Associations reveal|nmod|END_ENTITY	Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart_disease risk-related parameters .
17303804	0	adiponectin	22,33	insulin	37,44	adiponectin	insulin	9370	3630	Gene	Gene	influences|nmod|START_ENTITY influences|nmod|resistance resistance|compound|END_ENTITY	Genetic influences of adiponectin on insulin resistance , type 2 diabetes , and cardiovascular_disease .
17322583	0	adiponectin	9,20	insulin	30,37	adiponectin	insulin	9370	3630	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|secretion secretion|compound|END_ENTITY	Globular adiponectin augments insulin secretion from pancreatic islet beta cells at high glucose concentrations .
18208577	0	adiponectin	38,49	insulin	81,88	adiponectin	insulin	9370	3630	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression regulated|nsubjpass|effect regulated|nmod|status status|compound|END_ENTITY	Insulin effect on adipose_tissue -LRB- AT -RRB- adiponectin expression is regulated by the insulin resistance status of the patients .
18401239	0	adiponectin	11,22	insulin	38,45	adiponectin	insulin	9370	3630	Gene	Gene	concentration|compound|START_ENTITY concentration|appos|resistance resistance|compound|END_ENTITY	Postpartum adiponectin concentration , insulin resistance and metabolic_abnormalities among women with pregnancy-induced disturbances .
18440519	0	adiponectin	83,94	insulin	130,137	adiponectin	insulin	9370	3630	Gene	Gene	production|nmod|START_ENTITY production|dep|implications implications|nmod|sensitivity sensitivity|compound|END_ENTITY	Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo : implications for enhanced insulin sensitivity .
19755407	0	adiponectin	59,70	insulin	81,88	adiponectin	insulin	9370	3630	Gene	Gene	gene|compound|START_ENTITY G|nmod|gene Association|nmod|G Association|nmod|resistance resistance|compound|END_ENTITY	Association of the +45 T > G and +276 G > T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women .
20376890	0	adiponectin	88,99	insulin	105,112	adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Association of plasma retinol-binding_protein_4 , adiponectin , and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients .
20443850	0	adiponectin	44,55	insulin	66,73	adiponectin	insulin	9370	3630	Gene	Gene	gene|compound|START_ENTITY variant|nmod|gene Association|nmod|variant Association|nmod|resistance resistance|compound|END_ENTITY	Association of a polymorphic variant of the adiponectin gene with insulin resistance in african americans .
21306933	0	adiponectin	52,63	insulin	36,43	adiponectin	insulin	9370	3630	Gene	Gene	moderately|nsubj|START_ENTITY reduces|xcomp|moderately Intensifying|dep|reduces Intensifying|nmod|END_ENTITY	Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2 , but not in type 1 , diabetes .
21318144	0	adiponectin	65,76	insulin	27,34	adiponectin	insulin	9370	3630	Gene	Gene	levels|compound|START_ENTITY mediated|nmod|levels mediated|nsubjpass|resistance resistance|compound|END_ENTITY	Hyperthyroidism-associated insulin resistance is not mediated by adiponectin levels .
21458098	0	adiponectin	13,24	insulin	60,67	adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|nmod|assessment assessment|nmod|resistance resistance|compound|END_ENTITY	The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic_syndrome in an aged Japanese population : results from the KING Study .
22187345	0	adiponectin	16,27	insulin	112,119	adiponectin	insulin	9370	3630	Gene	Gene	Polymorphism|nmod|START_ENTITY Polymorphism|dep|relation relation|nmod|resistance resistance|compound|END_ENTITY	Polymorphism of adiponectin -LRB- 45T/G -RRB- _ and_adiponectin_receptor-2 -LRB- 795G/A -RRB- in an Iranian population : relation with insulin resistance and response to treatment with pioglitazone in patients with type_2_diabetes_mellitus .
22244787	0	adiponectin	45,56	insulin	101,108	adiponectin	insulin	9370	3630	Gene	Gene	adipokines|appos|START_ENTITY associated|nsubjpass|adipokines associated|nmod|resistance resistance|compound|END_ENTITY	Visceral fat mass is always , but adipokines -LRB- adiponectin and resistin -RRB- are diversely associated with insulin resistance in Chinese_type_2 diabetic and normoglycemic subjects .
22468049	0	adiponectin	15,26	insulin	43,50	adiponectin	insulin	9370	3630	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|resistance resistance|compound|END_ENTITY	Correlation of adiponectin and leptin with insulin resistance : a pilot study in healthy north Indian population .
22673293	0	adiponectin	16,27	insulin	55,62	adiponectin	insulin	9370	3630	Gene	Gene	levels|compound|START_ENTITY circulating|dobj|levels Low|acl|circulating associated|nsubjpass|Low associated|nmod|resistance resistance|compound|END_ENTITY	Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal_dialysis patients .
22841521	0	adiponectin	37,48	insulin	113,120	adiponectin	insulin	9370	3630	Gene	Gene	C-reactive_protein|compound|START_ENTITY osteoprotegerin|nmod|C-reactive_protein comparison|nmod|osteoprotegerin comparison|nmod|marker marker|nmod|resistance resistance|compound|END_ENTITY	A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive_protein -LRB- hsCRP -RRB- as a marker for insulin resistance .
23148188	0	adiponectin	6,17	insulin	46,53	adiponectin	insulin	9370	3630	Gene	Gene	Serum|dobj|START_ENTITY Serum|nmod|relation relation|nmod|resistance resistance|compound|END_ENTITY	Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism_in_lean_and_obese women with polycystic_ovary_syndrome .
23656997	0	adiponectin	35,46	insulin	76,83	adiponectin	insulin	9370	3630	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|dep|resistance resistance|compound|END_ENTITY	Single-nucleotide polymorphisms in adiponectin , AdipoR1 , and AdipoR2 genes : insulin resistance and type_2_diabetes_mellitus candidate genes .
23958652	0	adiponectin	27,38	insulin	62,69	adiponectin	insulin	9370	3630	Gene	Gene	polymorphism|compound|START_ENTITY _|dobj|polymorphism _|nmod|resistance resistance|compound|END_ENTITY	Association of the + _ 45T > G adiponectin gene polymorphism with insulin resistance in non-diabetic Saudi women .
24405382	0	adiponectin	8,19	insulin	69,76	adiponectin	insulin	9370	3630	Gene	Gene	START_ENTITY|acl|mediating mediating|nmod|resistance resistance|compound|END_ENTITY	Role of adiponectin in mediating the association of osteocalcin with insulin resistance and type 2 diabetes : a cross sectional study in pre - and post-menopausal women .
24640810	0	adiponectin	16,27	insulin	39,46	adiponectin	insulin	9370	3630	Gene	Gene	Status|nmod|START_ENTITY related|nsubj|Status related|nmod|resistance resistance|compound|END_ENTITY	Status of serum adiponectin related to insulin resistance in prediabetics .
25126860	0	adiponectin	37,48	insulin	14,21	adiponectin	insulin	9370	3630	Gene	Gene	sensitivity|nmod|START_ENTITY sensitivity|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of insulin sensitivity by adiponectin and its receptors in response to physical exercise .
26139044	0	adiponectin	44,55	insulin	70,77	adiponectin	insulin	9370	3630	Gene	Gene	gene|compound|START_ENTITY hypermethylation|nmod|gene mediates|nsubj|hypermethylation mediates|dobj|resistance resistance|compound|END_ENTITY	Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance .
26139044	0	adiponectin	44,55	insulin	70,77	adiponectin	insulin	9370	3630	Gene	Gene	gene|compound|START_ENTITY hypermethylation|nmod|gene mediates|nsubj|hypermethylation mediates|dobj|resistance resistance|compound|END_ENTITY	Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance .
26847448	0	adiponectin	25,36	insulin	66,73	adiponectin	insulin	9370	3630	Gene	Gene	fitness|appos|START_ENTITY fitness|appos|chemerin chemerin|acl|associated associated|xcomp|fasting fasting|dobj|level level|compound|END_ENTITY	Cardiopulmonary fitness , adiponectin , chemerin associated fasting insulin level in colorectal_cancer patients .
21839662	0	adiponectin	71,82	insulin-like_growth_factor-I	6,34	adiponectin	insulin-like growth factor-I	9370	3479	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Serum insulin-like_growth_factor-I is negatively associated with serum adiponectin in type 2 diabetes_mellitus .
16872712	0	adiponectin	6,17	interleukin-10	19,33	adiponectin	interleukin-10	9370	3586	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Serum adiponectin , interleukin-10 levels and inflammatory markers in the metabolic_syndrome .
15919832	0	adiponectin	64,75	interleukin-6	14,27	adiponectin	interleukin-6	9370	3569	Gene	Gene	sensitivity|compound|START_ENTITY polymorphism|nmod|sensitivity polymorphism|nsubj|Effect Effect|nmod|promoter promoter|amod|END_ENTITY	Effect of the interleukin-6 -LRB- -174 -RRB- g/c promoter polymorphism on adiponectin and insulin sensitivity .
17022850	0	adiponectin	41,52	interleukin-6	54,67	adiponectin	interleukin-6	9370	3569	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Effect of gliclazide modified release on adiponectin , interleukin-6 , and tumor_necrosis_factor-alpha plasma levels in individuals with type_2_diabetes_mellitus .
19885628	0	adiponectin	15,26	interleukin-6	30,43	adiponectin	interleukin-6	9370	3569	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The effects of adiponectin on interleukin-6 and MCP-1 secretion in lipopolysaccharide-treated 3T3-L1 adipocytes : role of the NF-kappaB pathway .
22549135	0	adiponectin	16,27	interleukin-6	68,81	adiponectin	interleukin-6	9370	3569	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|nmod|expression expression|acl|END_ENTITY	Synergy between adiponectin and interleukin-1b on the expression of interleukin-6 , interleukin-8 , and cyclooxygenase-2 in fibroblast-like synoviocytes .
22614149	0	adiponectin	61,72	interleukin-6	74,87	adiponectin	interleukin-6	9370	3569	Gene	Gene	bouts|nmod|START_ENTITY bouts|amod|END_ENTITY	Effects of repeated bouts of supramaximal exercise on plasma adiponectin , interleukin-6 , and tumor_necrosis_factor-a levels in sedentary men .
17403719	0	adiponectin	18,29	leptin	107,113	adiponectin	leptin	9370	3952	Gene	Gene	concentration|compound|START_ENTITY Increase|nmod|concentration Increase|dep|relationship relationship|nmod|END_ENTITY	Increase in serum adiponectin concentration in patients with heart_failure and cachexia : relationship with leptin , other cytokines , and B-type_natriuretic_peptide .
18191043	0	adiponectin	49,60	leptin	16,22	adiponectin	leptin	9370	3952	Gene	Gene	START_ENTITY|nsubj|Significance Significance|nmod|weight weight|compound|END_ENTITY	Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents .
18370715	0	adiponectin	14,25	leptin	4,10	adiponectin	leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	The leptin to adiponectin ratio is a good biomarker for the prevalence of metabolic_syndrome , dependent_on_visceral_fat_accumulation and endurance fitness in obese patients with diabetes_mellitus .
18925326	0	adiponectin	29,40	leptin	21,27	adiponectin	leptin	9370	3952	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	The relationships of leptin , adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs .
19482706	0	adiponectin	14,25	leptin	26,32	adiponectin	leptin	9370	3952	Gene	Gene	Targeting|dep|START_ENTITY Targeting|dep|ratio ratio|compound|END_ENTITY	Targeting the adiponectin : leptin ratio for postmenopausal_breast_cancer prevention .
19855365	0	adiponectin	8,19	leptin	21,27	adiponectin	leptin	9370	3952	Gene	Gene	Leptin|appos|START_ENTITY END_ENTITY|nsubj|Leptin	Leptin , adiponectin , leptin to adiponectin ratio and insulin resistance in depressive women .
20722673	0	adiponectin	45,56	leptin	21,27	adiponectin	leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY Associations|dep|ratio Associations|nmod|END_ENTITY	Associations between leptin and the leptin / adiponectin ratio and incident Type 2 diabetes in middle-aged men and women : results from the MONICA / KORA Augsburg study 1984-2002 .
21274300	0	adiponectin	148,159	leptin	73,79	adiponectin	leptin	9370	3952	Gene	Gene	marker|nsubj|START_ENTITY relationship|parataxis|marker relationship|nmod|levels levels|dep|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
21274300	0	adiponectin	31,42	leptin	73,79	adiponectin	leptin	9370	3952	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
21348878	0	adiponectin	31,42	leptin	15,21	adiponectin	leptin	9370	3952	Gene	Gene	START_ENTITY|nsubj|Reliability Reliability|nmod|END_ENTITY	Reliability of leptin , but not adiponectin , as a biomarker for diet-induced weight_loss in humans .
21821964	0	adiponectin	51,62	leptin	19,25	adiponectin	leptin	9370	3952	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Association of the leptin to high-molecular-weight adiponectin ratio with metabolic_syndrome .
21986458	0	adiponectin	98,109	leptin	90,96	adiponectin	leptin	9370	3952	Gene	Gene	visfatin|dep|START_ENTITY visfatin|compound|END_ENTITY	The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin , adiponectin , visfatin , and ghrelin levels in young female handball and basketball players .
22179449	0	adiponectin	77,88	leptin	6,12	adiponectin	leptin	9370	3952	Gene	Gene	expression|nmod|START_ENTITY correlated|nmod|expression correlated|nsubjpass|levels levels|compound|END_ENTITY	Serum leptin levels are inversely correlated with omental gene expression of adiponectin and markedly decreased after gastric_bypass_surgery .
23505188	0	adiponectin	27,38	leptin	19,25	adiponectin	leptin	9370	3952	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Maternal and fetal leptin , adiponectin levels and associations with fetal_insulin_sensitivity .
24052207	0	adiponectin	48,59	leptin	61,67	adiponectin	leptin	9370	3952	Gene	Gene	resistin|compound|START_ENTITY resistin|dep|END_ENTITY	Relationships between serum adipocyte hormones -LRB- adiponectin , leptin , resistin -RRB- , bone_mineral_density and bone metabolic markers in osteoporosis patients .
25690094	0	adiponectin	34,45	leptin	59,65	adiponectin	leptin	9370	3952	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Fish oil N-3_Fatty_acids increase adiponectin and decrease leptin levels in patients with systemic_lupus_erythematosus .
26374448	0	adiponectin	34,45	leptin	24,30	adiponectin	leptin	9370	3952	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Differential effects of leptin on adiponectin expression with weight_gain_versus_obesity .
26374448	0	adiponectin	34,45	leptin	24,30	adiponectin	leptin	9370	3952	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Differential effects of leptin on adiponectin expression with weight_gain_versus_obesity .
16138264	0	adiponectin	88,99	lipoprotein_lipase	16,34	adiponectin	lipoprotein lipase	9370	4023	Gene	Gene	levels|compound|START_ENTITY serum|dobj|levels Relationship|acl|serum Relationship|nmod|activity activity|amod|END_ENTITY	Relationship of lipoprotein_lipase and hepatic_triacylglycerol_lipase activity to serum adiponectin levels in Japanese hyperlipidemic men .
21252727	0	adiponectin	16,27	lipoprotein_lipase	102,120	adiponectin	lipoprotein lipase	9370	4023	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|mutations mutations|compound|END_ENTITY	Contribution of adiponectin to the cardiometabolic risk of postmenopausal women with loss-of-function lipoprotein_lipase gene mutations .
24905278	0	adiponectin	15,26	lipoprotein_lipase	49,67	adiponectin	lipoprotein lipase	9370	16956(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of adiponectin with serum preheparin lipoprotein_lipase mass in women independent of fat mass and distribution , insulin resistance , and inflammation .
18778866	0	adiponectin	22,33	myeloperoxidase	61,76	adiponectin	myeloperoxidase	9370	4353	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	High molecular weight adiponectin correlates positively with myeloperoxidase in patients with type_2_diabetes_mellitus .
21087777	0	adiponectin	11,22	osteoprotegerin	40,55	adiponectin	osteoprotegerin	9370	4982	Gene	Gene	associated|advcl|START_ENTITY associated|nsubjpass|levels levels|nmod|END_ENTITY	Similar to adiponectin , serum levels of osteoprotegerin are associated with obesity in healthy subjects .
22634178	0	adiponectin	28,39	osteoprotegerin	72,87	adiponectin	osteoprotegerin	9370	4982	Gene	Gene	17b-estradiol|nmod|START_ENTITY regulation|amod|17b-estradiol Effects|nmod|regulation Effects|nmod|expression expression|nmod|END_ENTITY	Effects of 17b-estradiol on adiponectin regulation of the expression of osteoprotegerin and receptor_activator_of_nuclear_factor-kB_ligand .
22841521	0	adiponectin	37,48	osteoprotegerin	16,31	adiponectin	osteoprotegerin	9370	4982	Gene	Gene	C-reactive_protein|compound|START_ENTITY END_ENTITY|nmod|C-reactive_protein	A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive_protein -LRB- hsCRP -RRB- as a marker for insulin resistance .
19887823	0	adiponectin	16,27	paraoxonase_1	33,46	adiponectin	paraoxonase 1	9370	5444	Gene	Gene	Associations|nmod|START_ENTITY Associations|nmod|END_ENTITY	Associations of adiponectin with paraoxonase_1 and sE-selectin in hemodialyzed patients .
11815513	0	adiponectin	110,121	peroxisome_proliferator-activated_receptor-gamma	10,58	adiponectin	peroxisome proliferator-activated receptor-gamma	9370	5468	Gene	Gene	levels|nmod|START_ENTITY increases|dobj|levels increases|nsubj|agonist agonist|amod|END_ENTITY	Synthetic peroxisome_proliferator-activated_receptor-gamma agonist , rosiglitazone , increases plasma levels of adiponectin in type 2 diabetic patients .
16914597	0	adiponectin	19,30	resistin	32,40	adiponectin	resistin	9370	56729	Gene	Gene	interleukin_6|compound|START_ENTITY interleukin_6|dep|END_ENTITY	Normative data for adiponectin , resistin , interleukin_6 , and leptin/receptor ratio in a healthy Spanish pediatric population : relationship with sex steroids .
18583069	0	adiponectin	50,61	resistin	16,24	adiponectin	resistin	9370	56729	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of resistin and its correlation with adiponectin and insulin in healthy full term neonates .
22944288	0	adiponectin	6,17	resistin	19,27	adiponectin	resistin	9370	56729	Gene	Gene	concentration|compound|START_ENTITY concentration|dep|END_ENTITY	Serum adiponectin , resistin , leptin concentration and central adiposity parameters in Barrett 's _ esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD .
26376464	0	adiponectin	45,56	resistin	79,87	adiponectin	resistin	9370	56729	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Liraglutide treatment causes upregulation of adiponectin and downregulation of resistin in Chinese_type_2_diabetes .
19846170	0	adiponectin	70,81	retinol-binding_protein_4	20,45	adiponectin	retinol-binding protein 4	9370	5950	Gene	Gene	Elevation|nmod|START_ENTITY Elevation|nmod|END_ENTITY	Elevation of plasma retinol-binding_protein_4 and reduction of plasma adiponectin in subjects with cerebral_infarction .
20376890	0	adiponectin	88,99	retinol-binding_protein_4	22,47	adiponectin	retinol-binding protein 4	9370	5950	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of plasma retinol-binding_protein_4 , adiponectin , and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients .
17661007	0	adiponectin	82,93	retinol_binding_protein_4	14,39	adiponectin	retinol binding protein 4	9370	5950	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|amod|END_ENTITY	Regulation of retinol_binding_protein_4 production in primary human adipocytes by adiponectin , troglitazone and TNF-alpha .
19498318	0	adiponectin	16,27	transforming_growth_factor_beta	141,172	adiponectin	transforming growth factor beta	9370	7040	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	The relation of adiponectin and tumor_necrosis_factor_alpha levels between endothelial_nitric_oxide_synthase , angiotensin-converting_enzyme , transforming_growth_factor_beta , and tumor_necrosis_factor_alpha gene polymorphism in adrenal_incidentalomas .
16254197	0	adiponectin	135,146	tumor_necrosis_factor-alpha	56,83	adiponectin	tumor necrosis factor-alpha	9370	7124	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene gene|nmod|polymorphism gene|amod|END_ENTITY	Interaction of the -308 G/A promoter polymorphism of the tumor_necrosis_factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene : effect on serum adiponectin concentrations in a Spanish population .
16254197	0	adiponectin	169,180	tumor_necrosis_factor-alpha	56,83	adiponectin	tumor necrosis factor-alpha	9370	7124	Gene	Gene	concentrations|compound|START_ENTITY effect|nmod|concentrations Interaction|dep|effect Interaction|nmod|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	Interaction of the -308 G/A promoter polymorphism of the tumor_necrosis_factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene : effect on serum adiponectin concentrations in a Spanish population .
17537727	0	adiponectin	50,61	tumor_necrosis_factor-alpha	72,99	adiponectin	tumor necrosis factor-alpha	9370	7124	Gene	Gene	macrophages|nmod|START_ENTITY treatment|nmod|macrophages increases|nsubj|treatment increases|dobj|expression expression|amod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
18334666	0	adiponectin	37,48	tumor_necrosis_factor-alpha	97,124	adiponectin	tumor necrosis factor-alpha	9370	24835(Tax:10116)	Gene	Gene	increases|nmod|START_ENTITY decrease|nsubj|increases decrease|dobj|cytokines cytokines|amod|END_ENTITY	Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor_necrosis_factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells .
21274300	0	adiponectin	148,159	tumor_necrosis_factor-alpha	44,71	adiponectin	tumor necrosis factor-alpha	9370	7124	Gene	Gene	marker|nsubj|START_ENTITY relationship|parataxis|marker relationship|nmod|levels levels|dep|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
21274300	0	adiponectin	31,42	tumor_necrosis_factor-alpha	44,71	adiponectin	tumor necrosis factor-alpha	9370	7124	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
25821324	0	adiponectin	10,21	vascular_endothelial_growth_factor	39,73	adiponectin	vascular endothelial growth factor	9370	7422	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of adiponectin on expression of vascular_endothelial_growth_factor and pigment epithelium-derived factor : An in vitro study .
18460569	0	adiponectin	53,64	visfatin	66,74	adiponectin	visfatin	9370	10135	Gene	Gene	and_insulin_growth_factor-I|compound|START_ENTITY and_insulin_growth_factor-I|dep|END_ENTITY	Gender specificity of body adiposity and circulating adiponectin , visfatin , insulin , _ and_insulin_growth_factor-I at term birth : relation to prenatal growth .
20208458	0	adiponectin	28,39	visfatin	67,75	adiponectin	visfatin	9370	10135	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Relationships between serum adiponectin , apelin , leptin , resistin , visfatin levels and bone_mineral_density , and bone biochemical markers in post-menopausal Chinese women .
21738955	0	adiponectin	26,37	visfatin	66,74	adiponectin	visfatin	9370	10135	Gene	Gene	adipokines|compound|START_ENTITY role|nmod|adipokines role|dep|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
21738955	0	adiponectin	26,37	visfatin	66,74	adiponectin	visfatin	9370	10135	Gene	Gene	adipokines|compound|START_ENTITY role|nmod|adipokines role|dep|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
24059114	0	adiponectin	15,26	visfatin	28,36	adiponectin	visfatin	9370	10135	Gene	Gene	leptin|appos|START_ENTITY END_ENTITY|nsubj|leptin	-LSB- Serum leptin , adiponectin , visfatin levels in adult GHD patients and correlation studies -RSB- .
20696134	0	adiponectin_receptor_1	26,48	ATF3	0,4	adiponectin receptor 1	ATF3	51094	467	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ATF3 negatively regulates adiponectin_receptor_1 expression .
22767440	0	adiponectin_receptor_1	63,85	AdipoR1	92,99	adiponectin receptor 1	AdipoR1	51094	51094	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No conclusive evidence for association of polymorphisms in the adiponectin_receptor_1 gene , AdipoR1 , with common obesity .
19010305	0	adiponectin_receptor_1	62,84	Receptor_for_activated_C-kinase_1	0,33	adiponectin receptor 1	Receptor for activated C-kinase 1	51094	10399	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Receptor_for_activated_C-kinase_1 , a novel binding partner of adiponectin_receptor_1 .
20178558	0	adiponectin_receptor_2	25,47	ADIPOR2	49,56	adiponectin receptor 2	ADIPOR2	79602	79602	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the adiponectin_receptor_2 -LRB- ADIPOR2 -RRB- gene is associated with coronary_artery_disease and increased ADIPOR2 expression in peripheral monocytes .
20380822	0	adiponectin_receptor_2	21,43	AdipoR2	45,52	adiponectin receptor 2	AdipoR2	68465(Tax:10090)	68465(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A potential role for adiponectin_receptor_2 -LRB- AdipoR2 -RRB- in the regulation of alcohol intake .
19336949	0	adiponectin_receptor_2	14,36	PPAR-alpha	52,62	adiponectin receptor 2	PPAR-alpha	68465(Tax:10090)	19013(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of adiponectin_receptor_2 expression via PPAR-alpha in NIT-1 cells .
21525193	0	adiponutrin	29,40	PNPLA3	21,27	adiponutrin	PNPLA3	80339	80339	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	Genetic variation in PNPLA3 -LRB- adiponutrin -RRB- confers sensitivity to weight loss-induced decrease in liver fat in humans .
18827892	0	adipophilin	38,49	CD36	0,4	adipophilin	CD36	123	948	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|END_ENTITY	CD36 is significantly correlated with adipophilin in human carotid lesions and inversely correlated with plasma ApoAI .
20710016	0	adipophilin	43,54	ERK1/2	63,69	adipophilin	ERK1/2	11520(Tax:10090)	26417;26413	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|pathway pathway|compound|END_ENTITY	Oxidized low-density lipoprotein activates adipophilin through ERK1/2 signal pathway in RAW264 .7 cells .
23512946	0	adipose	29,36	Adipose	0,7	adipose	Adipose	230796(Tax:10090)	230796(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|amod|END_ENTITY	Adipose tissue expression of adipose -LRB- WDTC1 -RRB- gene is associated with lower fat mass and enhanced insulin sensitivity in humans .
23512946	0	adipose	29,36	WDTC1	38,43	adipose	WDTC1	230796(Tax:10090)	23038	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Adipose tissue expression of adipose -LRB- WDTC1 -RRB- gene is associated with lower fat mass and enhanced insulin sensitivity in humans .
21562237	0	adipose	87,94	interleukin-6	47,60	adipose	interleukin-6	230796(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stearidonic_and_eicosapentaenoic_acids inhibit interleukin-6 expression in ob/ob mouse adipose stem cells via Toll-like_receptor-2-mediated pathways .
19774490	0	adipose_differentiation-related_protein	42,81	ADP	83,86	adipose differentiation-related protein	ADP	427237(Tax:9031)	427237(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Tissue-specific expression of the chicken adipose_differentiation-related_protein -LRB- ADP -RRB- gene .
16272134	0	adipose_differentiation-related_protein	14,53	ADRP	55,59	adipose differentiation-related protein	ADRP	123	123	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of adipose_differentiation-related_protein -LRB- ADRP -RRB- is conjointly regulated by PU .1 and AP-1 in macrophages .
19571381	0	adipose_differentiation-related_protein	29,68	retinoid_x_receptor	91,110	adipose differentiation-related protein	retinoid x receptor	123	6256	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Docosahexaenoic_acid induces adipose_differentiation-related_protein through activation of retinoid_x_receptor in human choriocarcinoma BeWo cells .
10623894	0	adipose_differentiation_related_protein	15,54	ADRP	56,60	adipose differentiation related protein	ADRP	123	123	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Stimulation of adipose_differentiation_related_protein -LRB- ADRP -RRB- expression in adipocyte precursors by long-chain fatty_acids .
21393244	0	adipose_triglyceride_lipase	21,48	ATGL	50,54	adipose triglyceride lipase	ATGL	57104	57104	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Unique regulation of adipose_triglyceride_lipase -LRB- ATGL -RRB- by perilipin_5 , a lipid_droplet-associated_protein .
22039468	0	adipose_triglyceride_lipase	22,49	ATGL	51,55	adipose triglyceride lipase	ATGL	57104	57104	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The minimal domain of adipose_triglyceride_lipase -LRB- ATGL -RRB- ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2 , respectively .
24627478	0	adipose_triglyceride_lipase	47,74	Fat-specific_protein_27	0,23	adipose triglyceride lipase	Fat-specific protein 27	57104	63924	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fat-specific_protein_27 -LRB- FSP27 -RRB- interacts with adipose_triglyceride_lipase -LRB- ATGL -RRB- to regulate lipolysis and insulin sensitivity in human adipocytes .
24742676	0	adipose_triglyceride_lipase	130,157	Fat-specific_protein_27	0,23	adipose triglyceride lipase	Fat-specific protein 27	57104	63924	Gene	Gene	transcription|nmod|START_ENTITY facilitating|nmod|transcription inhibits|advcl|facilitating inhibits|nsubj|END_ENTITY	Fat-specific_protein_27 inhibits lipolysis by facilitating the inhibitory effect of transcription factor Egr1 on transcription of adipose_triglyceride_lipase .
19297333	0	adipose_triglyceride_lipase	33,60	FoxO1	0,5	adipose triglyceride lipase	FoxO1	66853(Tax:10090)	56458(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	FoxO1 controls insulin-dependent adipose_triglyceride_lipase -LRB- ATGL -RRB- expression and lipolysis in adipocytes .
24002947	0	adipose_triglyceride_lipase	8,35	PNPLA2	37,43	adipose triglyceride lipase	PNPLA2	66853(Tax:10090)	66853(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of adipose_triglyceride_lipase -LRB- PNPLA2 -RRB- in protection from hepatic_inflammation in mouse models of steatohepatitis and endotoxemia .
17848638	0	adipose_triglyceride_lipase	20,47	PPARgamma	0,9	adipose triglyceride lipase	PPARgamma	66853(Tax:10090)	19016(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PPARgamma regulates adipose_triglyceride_lipase in adipocytes in vitro and in vivo .
25700221	0	adipose_triglyceride_lipase	79,106	Pigment_epithelium-derived_factor	0,33	adipose triglyceride lipase	Pigment epithelium-derived factor	57104	57104	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Pigment_epithelium-derived_factor regulates microvascular permeability through adipose_triglyceride_lipase in sepsis .
21148142	0	adipose_triglyceride_lipase	41,68	perilipin-5	16,27	adipose triglyceride lipase	perilipin-5	57104	440503	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of perilipin-5 -LRB- Plin5 -RRB- with adipose_triglyceride_lipase .
21393244	0	adipose_triglyceride_lipase	21,48	perilipin_5	59,70	adipose triglyceride lipase	perilipin 5	57104	440503	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Unique regulation of adipose_triglyceride_lipase -LRB- ATGL -RRB- by perilipin_5 , a lipid_droplet-associated_protein .
19026557	0	adipose_triglyceride_lipase	4,31	tumor_necrosis_factor-alpha	79,106	adipose triglyceride lipase	tumor necrosis factor-alpha	66853(Tax:10090)	21926(Tax:10090)	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|END_ENTITY	The adipose_triglyceride_lipase , adiponectin and visfatin are downregulated by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in vivo .
19087720	0	adipose_triglyceride_lipase	70,97	tumor_necrosis_factor-alpha	12,39	adipose triglyceride lipase	tumor necrosis factor-alpha	66853(Tax:10090)	21926(Tax:10090)	Gene	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	-LSB- Effects of tumor_necrosis_factor-alpha induced insulin resistance on adipose_triglyceride_lipase in mice -RSB- .
2679882	0	adipsin	40,47	Insulin	0,7	adipsin	Insulin	1675	3630	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Insulin stimulates the acute release of adipsin from 3T3-L1 adipocytes .
8044195	0	adipsin	18,25	adipsin	48,55	adipsin	adipsin	1675	1675	Gene	Gene	Concentrations|nmod|START_ENTITY Concentrations|nmod|END_ENTITY	Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal , elevated and diminished adipose tissue mass .
8044195	0	adipsin	48,55	adipsin	18,25	adipsin	adipsin	1675	1675	Gene	Gene	Concentrations|nmod|START_ENTITY Concentrations|nmod|END_ENTITY	Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal , elevated and diminished adipose tissue mass .
10909127	0	adrenergic_alpha_2A_receptor	24,52	ADRA2A	59,65	adrenergic alpha 2A receptor	ADRA2A	150	150	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the adrenergic_alpha_2A_receptor gene -LRB- ADRA2A -RRB- and measures of irritability , hostility , impulsivity and memory in normal subjects .
25985706	0	adrenergic_receptor_b2	17,39	ADRB2	10,15	adrenergic receptor b2	ADRB2	154	154	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effect of ADRB2 -LRB- adrenergic_receptor_b2 -RRB- gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial_asthma .
15626289	0	adrenocorticotropic_hormone	19,46	ACTH	48,52	adrenocorticotropic hormone	ACTH	5443	5443	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Value of assessing adrenocorticotropic_hormone -LRB- ACTH -RRB- levels in differential diagnosis of hypercorticism .
18128849	0	adrenocorticotropic_hormone	48,75	ACTH	77,81	adrenocorticotropic hormone	ACTH	5443	5443	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The metabolic and clinical effects of pituitary adrenocorticotropic_hormone -LRB- ACTH -RRB- in spontaneous hypoglycemosis .
6273137	0	adrenocorticotropic_hormone	172,199	TRH	116,119	adrenocorticotropic hormone	TRH	5443	7200	Gene	Gene	correlation|nmod|START_ENTITY correlation|appos|END_ENTITY	Inverse correlation between urinary 17-hydroxycorticosteroid -LRB- 17-OHCS -RRB- excretion and thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced thyrotropin -LRB- TSH -RRB- response in disorders of adrenocorticotropic_hormone -LRB- ACTH -RRB- and adrenal secretion .
10924347	0	adrenocorticotropic_hormone	14,41	acyl-CoA_synthetase_4	80,101	adrenocorticotropic hormone	acyl-CoA synthetase 4	5443	2182	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Regulation by adrenocorticotropic_hormone and arachidonate of the expression of acyl-CoA_synthetase_4 , an arachidonate-preferring enzyme expressed in steroidogenic tissues .
1318656	0	adrenocorticotropic_hormone	13,40	interleukin-6	52,65	adrenocorticotropic hormone	interleukin-6	5443	3569	Gene	Gene	Induction|nmod|START_ENTITY release|nsubj|Induction release|nmod|END_ENTITY	Induction of adrenocorticotropic_hormone release by interleukin-6 in vivo and in vitro .
3000730	0	adrenocorticotropin	57,76	Corticotropin-releasing_factor	0,30	adrenocorticotropin	Corticotropin-releasing factor	5443	1392	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Corticotropin-releasing_factor stimulates the release of adrenocorticotropin from domestic fowl pituitary cells .
7608277	0	adrenocorticotropin_receptor	24,52	ACTH-R	54,60	adrenocorticotropin receptor	ACTH-R	4158	4158	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel mutation of the adrenocorticotropin_receptor -LRB- ACTH-R -RRB- gene in a family with the syndrome of isolated_glucocorticoid_deficiency , but no ACTH-R abnormalities in two families with the triple_A_syndrome .
11342107	0	adrenoleukodystrophy-related	4,32	ALDR	34,38	adrenoleukodystrophy-related	ALDR	84356(Tax:10116)	84356(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rat adrenoleukodystrophy-related -LRB- ALDR -RRB- gene : full-length cDNA sequence and new insight in expression .
10329405	0	adrenoleukodystrophy_related	83,111	ALDR	113,117	adrenoleukodystrophy related	ALDR	225	225	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Full length cDNA cloning , promoter sequence , and genomic organization of the human adrenoleukodystrophy_related -LRB- ALDR -RRB- gene functionally redundant to the gene responsible for X-linked_adrenoleukodystrophy .
9877221	0	adrenomedullin	21,35	ADM	127,130	adrenomedullin	ADM	133	133	Gene	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Inhibitory effect of adrenomedullin -LRB- ADM -RRB- on the aldosterone response of human adrenocortical cells to angiotensin-II : role of ADM -LRB- 22-52 -RRB- - sensitive receptors .
10409481	0	adrenomedullin	88,102	Adrenomedullin	0,14	adrenomedullin	Adrenomedullin	133	133	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Adrenomedullin in monocytes and macrophages : possible involvement of macrophage-derived adrenomedullin in atherogenesis .
15971150	0	adrenomedullin	34,48	Angiotensin_II	0,14	adrenomedullin	Angiotensin II	133	183	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates cardiac adrenomedullin production and causes accumulation of mature adrenomedullin independently of hemodynamic stress in vivo .
15971150	0	adrenomedullin	94,108	Angiotensin_II	0,14	adrenomedullin	Angiotensin II	133	183	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates cardiac adrenomedullin production and causes accumulation of mature adrenomedullin independently of hemodynamic stress in vivo .
26035796	0	adrenomedullin	40,54	Bcl-2	75,80	adrenomedullin	Bcl-2	133	596	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Hypoxia-induced apoptosis is blocked by adrenomedullin via upregulation of Bcl-2 in human osteosarcoma cells .
18222566	0	adrenomedullin	7,21	C-reactive_protein	121,139	adrenomedullin	C-reactive protein	133	1401	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Plasma adrenomedullin as an independent predictor of future cardiovascular events in high-risk patients : comparison with C-reactive_protein and adiponectin .
9228512	0	adrenomedullin	27,41	C-reactive_protein	78,96	adrenomedullin	C-reactive protein	133	1401	Gene	Gene	circulating|dobj|START_ENTITY levels|acl|circulating levels|dep|correlation correlation|nmod|END_ENTITY	High levels of circulating adrenomedullin in severe illness : correlation with C-reactive_protein and evidence against the adrenal medulla as site of origin .
11585594	0	adrenomedullin	124,138	CGRP	154,158	adrenomedullin	CGRP	25026(Tax:10116)	24241(Tax:10116)	Gene	Gene	START_ENTITY|nmod|addition addition|nmod|END_ENTITY	The calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonist CGRP -LRB- 8-37 -RRB- blocks vasodilatation in inflamed rat skin : involvement of adrenomedullin in addition to CGRP .
12099714	0	adrenomedullin	49,63	EPAS1	109,114	adrenomedullin	EPAS1	133	2034	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Endothelial_PAS_domain_protein_1 -LRB- EPAS1 -RRB- induces adrenomedullin gene expression in cardiac myocytes : role of EPAS1 in an inflammatory response in cardiac myocytes .
12099714	0	adrenomedullin	49,63	Endothelial_PAS_domain_protein_1	0,32	adrenomedullin	Endothelial PAS domain protein 1	133	2034	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Endothelial_PAS_domain_protein_1 -LRB- EPAS1 -RRB- induces adrenomedullin gene expression in cardiac myocytes : role of EPAS1 in an inflammatory response in cardiac myocytes .
15307819	0	adrenomedullin	39,53	Matrix_metalloproteinase-2	0,26	adrenomedullin	Matrix metalloproteinase-2	25026(Tax:10116)	81686(Tax:10116)	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Matrix_metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator .
16821090	0	adrenomedullin	14,28	PTEN	0,4	adrenomedullin	PTEN	133	5728	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	PTEN inhibits adrenomedullin expression and function in brain_tumor cells .
12732346	0	adrenomedullin	11,25	RAMP2	69,74	adrenomedullin	RAMP2	25026(Tax:10116)	58966(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes of adrenomedullin and receptor_activity_modifying_protein_2 -LRB- RAMP2 -RRB- in myocardium and aorta in rats with isoproterenol-induced myocardial_ischemia .
17719138	0	adrenomedullin	36,50	Sp1	68,71	adrenomedullin	Sp1	133	6667	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha .
15971150	0	adrenomedullin	34,48	adrenomedullin	94,108	adrenomedullin	adrenomedullin	133	133	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Angiotensin_II stimulates cardiac adrenomedullin production and causes accumulation of mature adrenomedullin independently of hemodynamic stress in vivo .
15971150	0	adrenomedullin	94,108	adrenomedullin	34,48	adrenomedullin	adrenomedullin	133	133	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Angiotensin_II stimulates cardiac adrenomedullin production and causes accumulation of mature adrenomedullin independently of hemodynamic stress in vivo .
20431304	0	adrenomedullin	11,25	adrenomedullin	44,58	adrenomedullin	adrenomedullin	25026(Tax:10116)	25026(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|compound|END_ENTITY	Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis .
20431304	0	adrenomedullin	44,58	adrenomedullin	11,25	adrenomedullin	adrenomedullin	25026(Tax:10116)	25026(Tax:10116)	Gene	Gene	system|compound|START_ENTITY Effects|nmod|system Effects|nmod|END_ENTITY	Effects of adrenomedullin on the glomerular adrenomedullin system in a rat model of anti-thy1 glomerulonephritis .
21690075	0	adrenomedullin	21,35	adrenomedullin	62,76	adrenomedullin	adrenomedullin	25026(Tax:10116)	25026(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of exogenous adrenomedullin on renal and hypothalamus adrenomedullin expression in rats early after mechanical renal trauma -RSB- .
21690075	0	adrenomedullin	62,76	adrenomedullin	21,35	adrenomedullin	adrenomedullin	25026(Tax:10116)	25026(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of exogenous adrenomedullin on renal and hypothalamus adrenomedullin expression in rats early after mechanical renal trauma -RSB- .
11410122	0	adrenomedullin	47,61	angiotensin_II	112,126	adrenomedullin	angiotensin II	133	183	Gene	Gene	effects|nmod|START_ENTITY thresholds|nmod|effects infusion|nsubj|thresholds infusion|nmod|END_ENTITY	Differing thresholds for modulatory effects of adrenomedullin infusion on haemodynamic and hormone responses to angiotensin_II and adrenocorticotrophic hormone in healthy volunteers .
11754973	0	adrenomedullin	11,25	angiotensin_II	63,77	adrenomedullin	angiotensin II	25026(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY induced|nsubj|Effects induced|nmod|END_ENTITY	Effects of adrenomedullin on hypertrophic responses induced by angiotensin_II , endothelin-1 and phenylephrine .
14620929	0	adrenomedullin	78,92	angiotensin_II	60,74	adrenomedullin	angiotensin II	11535(Tax:10090)	11606(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Accelerated cardiac_hypertrophy and renal_damage induced by angiotensin_II in adrenomedullin knockout mice .
15295719	0	adrenomedullin	47,61	angiotensin_II	65,79	adrenomedullin	angiotensin II	25026(Tax:10116)	24179(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY study|nmod|effects study|nmod|contraction contraction|amod|END_ENTITY	Comparative study of the inhibitory effects of adrenomedullin on angiotensin_II contraction in rat conductance and resistance arteries .
27096064	0	adrenomedullin	14,28	angiotensin_II	76,90	adrenomedullin	angiotensin II	25026(Tax:10116)	24179(Tax:10116)	Gene	Gene	peptide|compound|START_ENTITY effect|nmod|peptide effect|nmod|END_ENTITY	The effect of adrenomedullin and proadrenomedullin_N-terminal 20 peptide on angiotensin_II induced vascular smooth muscle cell proliferation .
15044054	0	adrenomedullin	10,24	c-Met	28,33	adrenomedullin	c-Met	25026(Tax:10116)	24553(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of adrenomedullin on c-Met receptor expression after reserpine-induced gastric_damage in the rat .
10218987	0	adrenomedullin	23,37	c-fos	88,93	adrenomedullin	c-fos	25026(Tax:10116)	314322(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|level level|nmod|induction induction|nmod|messenger messenger|amod|END_ENTITY	Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic_acid in the paraventricular and supraoptic nuclei of the rat .
15224145	0	adrenomedullin	42,56	c-fos	85,90	adrenomedullin	c-fos	25026(Tax:10116)	314322(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY increases|nsubj|administration increases|dobj|expression expression|nmod|END_ENTITY	Intracerebroventricular administration of adrenomedullin increases the expression of c-fos and activates nitric_oxide-producing neurons in rat cardiovascular related brain nuclei .
21171326	0	adrenomedullin	48,62	c-fos	110,115	adrenomedullin	c-fos	25026(Tax:10116)	314322(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of intracerebroventricular injection of adrenomedullin on catecholaminergic neurons and expression of c-fos in the rat brain nuclei involved in cardiovascular regulation -RSB- .
12135324	0	adrenomedullin	32,46	calcitonin_gene-related_peptide	81,112	adrenomedullin	calcitonin gene-related peptide	25026(Tax:10116)	24241(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|dep|comparison comparison|nmod|END_ENTITY	Regional hemodynamic effects of adrenomedullin in Wistar_rats : a comparison with calcitonin_gene-related_peptide .
11410113	0	adrenomedullin	10,24	endothelin-1	46,58	adrenomedullin	endothelin-1	133	1906	Gene	Gene	START_ENTITY|nmod|production production|nmod|arteries arteries|amod|END_ENTITY	Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries : evidence for a receptor-specific functional interaction in patients with heart_failure .
11754973	0	adrenomedullin	11,25	endothelin-1	79,91	adrenomedullin	endothelin-1	25026(Tax:10116)	24323(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY induced|nsubj|Effects induced|nmod|angiotensin_II angiotensin_II|amod|END_ENTITY	Effects of adrenomedullin on hypertrophic responses induced by angiotensin_II , endothelin-1 and phenylephrine .
12379507	0	adrenomedullin	38,52	endothelin-1	11,23	adrenomedullin	endothelin-1	133	1906	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of endothelin-1 on release of adrenomedullin and C-type_natriuretic_peptide from individual human vascular endothelial cells .
15930287	0	adrenomedullin	98,112	interleukin_1beta	29,46	adrenomedullin	interleukin 1beta	133	3553	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	The proinflammatory cytokine interleukin_1beta and hypoxia cooperatively induce the expression of adrenomedullin in ovarian_carcinoma cells through hypoxia_inducible_factor_1 activation .
23745696	0	adrenomedullin	98,112	intermedin	22,32	adrenomedullin	intermedin	133	79924	Gene	Gene	comparison|nmod|START_ENTITY effects|dep|comparison effects|nmod|END_ENTITY	Protective effects of intermedin on cardiovascular , pulmonary_and_renal_diseases : comparison with adrenomedullin and CGRP .
17947702	0	adrenomedullin	19,33	peroxisome_proliferator-activated_receptor-gamma	102,150	adrenomedullin	peroxisome proliferator-activated receptor-gamma	133	5468	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Vasoactive hormone adrenomedullin and its binding protein : anti-inflammatory effects by up-regulating peroxisome_proliferator-activated_receptor-gamma .
16266462	0	adrenomedullin	40,54	urotensin_II	11,23	adrenomedullin	urotensin II	133	10911	Gene	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Effect of urotensin_II on secretion of adrenomedullin from human vascular endothelial cells -RSB- .
21558971	0	adrenomedullin	20,34	vascular_endothelial_growth_factor	43,77	adrenomedullin	vascular endothelial growth factor	11535(Tax:10090)	22339(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|induction induction|compound|END_ENTITY	Angiogenic roles of adrenomedullin through vascular_endothelial_growth_factor induction .
19535789	0	adrenomedullin_2	14,30	intermedin	38,48	adrenomedullin 2	intermedin	79924	79924	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of adrenomedullin_2 -LRB- ADM2 -RRB- / intermedin -LRB- IMD -RRB- in human placenta : role in trophoblast invasion and migration .
21180135	0	adrenomedullin_2	12,28	intermedin	29,39	adrenomedullin 2	intermedin	399475(Tax:10116)	399475(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|dep|END_ENTITY	-LSB- Changes of adrenomedullin_2 / intermedin in the lung of rats with chronic hypoxic pulmonary hypertension -RSB- .
25102228	0	adrenomedullin_2	13,29	intermedin	30,40	adrenomedullin 2	intermedin	399475(Tax:10116)	399475(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Induction of adrenomedullin_2 / intermedin expression by thyroid stimulating hormone in thyroid .
11997247	0	adrenomedullin_receptor	20,43	receptor_activity_modifying_protein-3	61,98	adrenomedullin receptor	receptor activity modifying protein-3	29307(Tax:10116)	56820(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Novel regulation of adrenomedullin_receptor by PDGF : role of receptor_activity_modifying_protein-3 .
9671468	0	adseverin	7,16	interleukin-9	98,111	adseverin	interleukin-9	20259(Tax:10090)	16198(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Murine adseverin -LRB- D5 -RRB- , a novel member of the gelsolin family , and murine adseverin are induced by interleukin-9 in T-helper lymphocytes .
18796298	0	advanced_glycosylation_end_product-specific_receptor	17,69	AGER	71,75	advanced glycosylation end product-specific receptor	AGER	177	177	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in advanced_glycosylation_end_product-specific_receptor -LRB- AGER -RRB- gene , insulin resistance , and type_2_diabetes_mellitus .
11279138	0	af1/tau1	48,56	glucocorticoid_receptor	24,47	af1/tau1	glucocorticoid receptor	3460	2908	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	The conformation of the glucocorticoid_receptor af1/tau1 domain induced by osmolyte binds co-regulatory proteins .
19589776	0	afadin	14,20	Rap1	64,68	afadin	Rap1	17356(Tax:10090)	109905(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation by afadin of cyclical activation and inactivation of Rap1 , Rac1 , and RhoA small G proteins at leading edges of moving NIH3T3 cells .
17971444	0	afadin	68,74	SHP-2	83,88	afadin	SHP-2	17356(Tax:10090)	19247(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2 : implications for cellular morphology .
20413783	0	afadin	8,14	vascular_endothelial_growth_factor	18,52	afadin	vascular endothelial growth factor	17356(Tax:10090)	7422	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of afadin in vascular_endothelial_growth_factor - and sphingosine_1-phosphate-induced angiogenesis .
16868028	0	afd1	11,15	REC8	24,28	afd1	REC8	732730(Tax:4577)	732730(Tax:4577)	Gene	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	Alleles of afd1 dissect REC8 functions during meiotic prophase I. REC8 is a master regulator of chromatin structure and function during meiosis .
15835269	0	affixin	25,32	Dysferlin	0,9	affixin	Dysferlin	29780	8291	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dysferlin interacts with affixin -LRB- beta-parvin -RRB- at the sarcolemma .
12461698	0	age-related_hearing_impairment	35,65	DFNA5	3,8	age-related hearing impairment	DFNA5	9077	1687	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Is DFNA5 a susceptibility gene for age-related_hearing_impairment ?
22326520	0	age-related_hearing_loss	36,60	Cdh23	64,69	age-related hearing loss	Cdh23	22295(Tax:10090)	22295(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	A mutation in the cdh23 gene causes age-related_hearing_loss in Cdh23 -LRB- nmf308/nmf308 -RRB- mice .
22219653	0	age-related_maculopathy_susceptibility_2	148,188	ARMS2	195,200	age-related maculopathy susceptibility 2	ARMS2	387715	387715	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Difference between age-related_macular_degeneration and polypoidal_choroidal_vasculopathy in the hereditary contribution of the A69S variant of the age-related_maculopathy_susceptibility_2 gene -LRB- ARMS2 -RRB- .
23602832	0	aggrecanase-1	73,86	ADAMTS-4	88,96	aggrecanase-1	ADAMTS-4	9507	9507	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inflammatory cytokines associated with degenerative_disc_disease control aggrecanase-1 -LRB- ADAMTS-4 -RRB- expression in nucleus pulposus cells through MAPK and NF-kB .
11254106	0	aggrecanase-1	48,61	ADAMTS4	63,70	aggrecanase-1	ADAMTS4	9507	9507	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Characterization of 5 ' - flanking region of human aggrecanase-1 -LRB- ADAMTS4 -RRB- gene .
11311239	0	aggrecanase-1	23,36	ADAMTS4	14,21	aggrecanase-1	ADAMTS4	9507	9507	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ADAMTS4 -LRB- aggrecanase-1 -RRB- by tissue_inhibitors_of_metalloproteinases -LRB- TIMP-1 , _ 2 , _ 3_and_4 -RRB- .
17922681	0	aggrecanase-1	23,36	ADAMTS4	14,21	aggrecanase-1	ADAMTS4	9507	9507	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of ADAMTS4 -LRB- aggrecanase-1 -RRB- in human osteoarthritic cartilage .
11311239	0	aggrecanase-1	23,36	tissue_inhibitors_of_metalloproteinases	41,80	aggrecanase-1	tissue inhibitors of metalloproteinases	9507	7076	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ADAMTS4 -LRB- aggrecanase-1 -RRB- by tissue_inhibitors_of_metalloproteinases -LRB- TIMP-1 , _ 2 , _ 3_and_4 -RRB- .
12746310	0	aggrecanase-2	25,38	ADAM-TS5	39,47	aggrecanase-2	ADAM-TS5	100008799(Tax:9986)	304135(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Thyroid hormone enhances aggrecanase-2 / ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage .
11278243	0	aggrecanase_1	32,45	TIMP-3	0,6	aggrecanase 1	TIMP-3	9507	7078	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	TIMP-3 is a potent inhibitor of aggrecanase_1 -LRB- ADAM-TS4 -RRB- and aggrecanase_2 -LRB- ADAM-TS5 -RRB- .
22357971	0	agouti-related_peptide	49,71	AMP-activated_protein_kinase	87,115	agouti-related peptide	AMP-activated protein kinase	181	5562	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The ketone body b-hydroxybutyric_acid influences agouti-related_peptide expression via AMP-activated_protein_kinase in hypothalamic GT1-7 cells .
10329427	0	agouti-related_protein	24,46	AGRP	48,52	agouti-related protein	AGRP	25582(Tax:10116)	25582(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in hypothalamic agouti-related_protein -LRB- AGRP -RRB- , but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats .
12668211	0	agouti-related_protein	32,54	AGRP	56,60	agouti-related protein	AGRP	181	181	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Elongation studies of the human agouti-related_protein -LRB- AGRP -RRB- core decapeptide -LRB- Yc -LSB- CRFFNAFC -RSB- Y -RRB- results in antagonism at the mouse melanocortin-3_receptor .
15193430	0	agouti-related_protein	29,51	AGRP	53,57	agouti-related protein	AGRP	11604(Tax:10090)	11604(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Down-regulated expression of agouti-related_protein -LRB- AGRP -RRB- mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice .
15597192	0	agouti-related_protein	14,36	AgRP	38,42	agouti-related protein	AgRP	101804660	101804660	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of agouti-related_protein -LRB- AgRP -RRB- in the hypothalamus and adrenal gland of the duck -LRB- Anas_platyrhynchos -RRB- .
20102560	0	agouti-related_protein	28,50	AgRP	52,56	agouti-related protein	AgRP	11604(Tax:10090)	11604(Tax:10090)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Ethanol-induced increase of agouti-related_protein -LRB- AgRP -RRB- immunoreactivity in the arcuate nucleus of the hypothalamus of C57BL/6J , but not 129/SvJ , inbred mice .
23774689	0	agouti-related_protein	56,78	AgRP	80,84	agouti-related protein	AgRP	181	181	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Characterization , tissue distribution and regulation of agouti-related_protein -LRB- AgRP -RRB- in a cyprinid fish -LRB- Schizothorax prenanti -RRB- .
15345681	0	agouti-related_protein	30,52	Agrp	54,58	agouti-related protein	Agrp	11604(Tax:10090)	11604(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of agouti-related_protein -LRB- Agrp -RRB- in transgenic_mice .
17525122	0	agouti-related_protein	107,129	alpha-melanocyte-stimulating_hormone	163,199	agouti-related protein	alpha-melanocyte-stimulating hormone	181	5443	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- is colocalized with the orexigenic neuropeptide Y and agouti-related_protein and absent from the anorexigenic alpha-melanocyte-stimulating_hormone neurons in the infundibular nucleus of the human hypothalamus .
15582725	0	agouti-related_protein	14,36	growth_hormone	40,54	agouti-related protein	growth hormone	25582(Tax:10116)	81668(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of agouti-related_protein on growth_hormone secretion in adult male rats .
10652218	0	agouti-related_protein	81,103	melanocortin-4_receptor	104,127	agouti-related protein	melanocortin-4 receptor	25582(Tax:10116)	25635(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related_protein / melanocortin-4_receptor system .
11352754	0	agouti-related_protein	101,123	melanocortin-4_receptor	34,57	agouti-related protein	melanocortin-4 receptor	11604(Tax:10090)	17202(Tax:10090)	Gene	Gene	identification|nmod|START_ENTITY studies|dep|identification studies|nmod|END_ENTITY	Structure activity studies of the melanocortin-4_receptor by in vitro mutagenesis : identification of agouti-related_protein -LRB- AGRP -RRB- , melanocortin agonist and synthetic peptide antagonist interaction determinants .
11487744	0	agouti-related_protein	48,70	melanocortin-4_receptor	23,46	agouti-related protein	melanocortin-4 receptor	181	4160	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Mutational analysis of melanocortin-4_receptor , agouti-related_protein , and alpha-melanocyte-stimulating_hormone genes in severely obese children .
15084118	0	agouti-related_protein	27,49	melanocortin-4_receptor	58,81	agouti-related protein	melanocortin-4 receptor	11604(Tax:10090)	17202(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|interactions interactions|amod|END_ENTITY	Identification of putative agouti-related_protein -LRB- 87-132 -RRB- - melanocortin-4_receptor interactions by homology molecular modeling and validation using chimeric peptide ligands .
15615519	0	agouti-related_protein	41,63	melanocortin-4_receptor	112,135	agouti-related protein	melanocortin-4 receptor	181	4160	Gene	Gene	studies|nmod|START_ENTITY studies|dep|conversion conversion|nmod|antagonist antagonist|amod|END_ENTITY	Stereochemical studies of the monocyclic agouti-related_protein -LRB- 103-122 -RRB- Arg-Phe-Phe residues : conversion of a melanocortin-4_receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist .
10342854	0	agouti-related_protein	22,44	neuropeptide_Y	73,87	agouti-related protein	neuropeptide Y	181	4852	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Altered expression of agouti-related_protein and its colocalization with neuropeptide_Y in the arcuate nucleus of the hypothalamus during lactation .
15726415	0	agouti_signaling_protein	24,48	ASIP	50,54	agouti signaling protein	ASIP	434	434	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 8818G allele of the agouti_signaling_protein -LRB- ASIP -RRB- gene is ancestral and is associated with darker skin color in African Americans .
20004240	0	agouti_signaling_protein	31,55	ASIP	57,61	agouti signaling protein	ASIP	100144328(Tax:9986)	100144328(Tax:9986)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the rabbit agouti_signaling_protein -LRB- ASIP -RRB- gene : transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colour .
20016133	0	agouti_signaling_protein	52,76	ASIP	78,82	agouti signaling protein	ASIP	100860915	100860915	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Copy number variation and missense mutations of the agouti_signaling_protein -LRB- ASIP -RRB- gene in goat breeds with different coat colors .
22554923	0	agouti_signaling_protein	33,57	ASIP	59,63	agouti signaling protein	ASIP	419147(Tax:9031)	419147(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Conserved distal promoter of the agouti_signaling_protein -LRB- ASIP -RRB- gene controls sexual_dichromatism in chickens .
23661018	0	agouti_signaling_protein	57,81	ASIP	83,87	agouti signaling protein	ASIP	100860915	100860915	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of single nucleotide polymorphisms in the agouti_signaling_protein -LRB- ASIP -RRB- gene in some goat breeds in tropical and temperate climates .
18957220	0	agrin	31,36	LRP4	0,4	agrin	LRP4	375790	4038	Gene	Gene	coreceptor|nmod|START_ENTITY serves|nmod|coreceptor serves|nsubj|END_ENTITY	LRP4 serves as a coreceptor of agrin .
10770843	0	agrin	35,40	Matrix_metalloproteinase-3	0,26	agrin	Matrix metalloproteinase-3	375790	4314	Gene	Gene	removes|dobj|START_ENTITY removes|nsubj|END_ENTITY	Matrix_metalloproteinase-3 removes agrin from synaptic basal lamina .
17927773	0	agrin	11,16	aquaporin-4	81,92	agrin	aquaporin-4	11603(Tax:10090)	11829(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in cultured astrocytes .
9184982	0	agrin	41,46	heparan_sulfate_proteoglycan	50,78	agrin	heparan sulfate proteoglycan	375790	960	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Distribution and substrate properties of agrin , a heparan_sulfate_proteoglycan of developing axonal pathways .
11820637	0	ahr	20,23	ahr	36,39	ahr	ahr	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Low activity of the ahr gene in the ahr dd C57BL congenic mice does not prevent the depression of birth rates observed as result of cigarette smoke exposure .
11820637	0	ahr	36,39	ahr	20,23	ahr	ahr	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Low activity of the ahr gene in the ahr dd C57BL congenic mice does not prevent the depression of birth rates observed as result of cigarette smoke exposure .
22108652	0	aid	70,73	SHOX2	56,61	aid	SHOX2	57379	6474	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung_cancer based on the analysis of bronchial aspirates .
3478802	0	aid	16,19	Sri	23,26	aid	Sri	57379	6717	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Dental foreign aid in Sri Lanka -RSB- .
8137202	0	aid	31,34	c-myc	14,19	aid	c-myc	57379	4609	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of c-myc mRNA as an aid in histologic differentiation of adenoma from well differentiated adenocarcinoma in the stomach .
1682495	0	aid	61,64	phenylalanine_hydroxylase	24,49	aid	phenylalanine hydroxylase	57379	5053	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Silent mutations in the phenylalanine_hydroxylase gene as an aid to the diagnosis of phenylketonuria .
25202675	0	ak_1	37,41	adenylate_kinase_locus_1	11,35	ak 1	adenylate kinase locus 1	203	203	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	A study of adenylate_kinase_locus_1 -LRB- ak_1 -RRB- genetic polymorphism in diabetic_pregnancy .
12914526	0	akr1b7	78,84	aldose_reductase-like	51,72	akr1b7	aldose reductase-like	11997(Tax:10090)	102642655	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Hormonal and developmental regulation of the mouse aldose_reductase-like gene akr1b7 expression in Leydig cells .
10900165	0	akt	31,34	Cardiotrophin-1	0,15	akt	Cardiotrophin-1	207	1489	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cardiotrophin-1 phosphorylates akt and BAD , and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes .
24603862	0	akt	37,40	Fibroblast_growth_factor_9	0,26	akt	Fibroblast growth factor 9	11651(Tax:10090)	14180(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY activates|dobj|pathways activates|nsubj|END_ENTITY	Fibroblast_growth_factor_9 activates akt and MAPK pathways to stimulate steroidogenesis in mouse leydig cells .
19956390	0	akt	38,41	Focal_adhesion_kinase	0,21	akt	Focal adhesion kinase	11651(Tax:10090)	14083(Tax:10090)	Gene	Gene	target|amod|START_ENTITY functions|nmod|target functions|amod|END_ENTITY	Focal_adhesion_kinase functions as an akt downstream target in migration of colorectal_cancer cells .
19520917	0	akt	30,33	Phosphatidylinositol-3-kinase	0,29	akt	Phosphatidylinositol-3-kinase	207	5290	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Phosphatidylinositol-3-kinase / akt regulates bleomycin-induced fibroblast proliferation and collagen production .
19133120	0	akt	93,96	Phosphoinositide_3-kinase	0,25	akt	Phosphoinositide 3-kinase	207	5293	Gene	Gene	expression|amod|START_ENTITY negates|dobj|expression negates|nsubj|END_ENTITY	Phosphoinositide_3-kinase targeting by the beta galactoside binding protein cytokine negates akt gene expression and leads aggressive breast_cancer cells to apoptotic death .
17426084	0	akt	99,102	phosphatidylinositol-3-kinase	69,98	akt	phosphatidylinositol-3-kinase	207	5290	Gene	Gene	START_ENTITY|nsubj|prevalence prevalence|nmod|genetic_alterations genetic_alterations|nmod|/ /|amod|END_ENTITY	High prevalence and mutual exclusivity of genetic_alterations in the phosphatidylinositol-3-kinase / akt pathway in thyroid_tumors .
18358617	0	akt	52,55	phosphatidylinositol_3-kinase	22,51	akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	298947(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|/ /|amod|END_ENTITY	Differential roles of phosphatidylinositol_3-kinase / akt pathway in retinal ganglion cell survival in rats with or without acute_ocular_hypertension .
19068483	0	akt	34,37	phosphatidylinositol_3-kinase	4,33	akt	phosphatidylinositol 3-kinase	11651(Tax:10090)	18708(Tax:10090)	Gene	Gene	cassette|compound|START_ENTITY cassette|amod|END_ENTITY	The phosphatidylinositol_3-kinase / akt cassette regulates purine nucleotide synthesis .
25824462	0	akt	40,43	phosphatidylinositol_3-kinase	10,39	akt	phosphatidylinositol 3-kinase	24185(Tax:10116)	85243(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	Activated phosphatidylinositol_3-kinase / akt inhibits the transition of endothelial progenitor cells to mesenchymal cells by regulating the forkhead box subgroup o-3a signaling .
12176338	0	akt	80,83	protein_kinase_b	63,79	akt	protein kinase b	207	2185	Gene	Gene	bound|advmod|START_ENTITY structure|dep|bound structure|nmod|domain domain|nmod|END_ENTITY	High-resolution structure of the pleckstrin homology domain of protein_kinase_b / akt bound to phosphatidylinositol _ -LRB- 3,4,5 -RRB- - trisphosphate .
16899523	0	alanine_aminotransferase	20,44	AlaAT	46,51	alanine aminotransferase	AlaAT	11444017	11444017	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of alanine_aminotransferase -LRB- AlaAT -RRB- multigene family and hypoxic response in young seedlings of the model legume Medicago_truncatula .
18455211	0	alanine_aminotransferase	46,70	PPARalpha	0,9	alanine aminotransferase	PPARalpha	2875	5465	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PPARalpha regulates the hepatotoxic biomarker alanine_aminotransferase -LRB- ALT1 -RRB- gene expression in human hepatocytes .
17786278	0	alanyl-aminopeptidase	14,35	CD4	39,42	alanyl-aminopeptidase	CD4	16790(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Inhibition of alanyl-aminopeptidase on CD4 + CD25 + regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute_colitis in mice .
1895489	0	albumin	12,19	Albumin	71,78	albumin	Albumin	213	213	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of albumin in human physiology and pathophysiology , Part III : Albumin and disease states .
9472473	0	albumin	21,28	IL-8	37,41	albumin	IL-8	213	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Glycated human serum albumin induces IL-8 and MCP-1 gene expression in human corneal keratocytes .
4069309	1	albumin	69,76	Leu-enkephalin	48,62	albumin	Leu-enkephalin	213	5173	Gene	Gene	interaction|compound|START_ENTITY interaction|amod|END_ENTITY	II : Leu-enkephalin serum albumin interaction .
7318045	0	albumin	26,33	albumin	55,62	albumin	albumin	213	213	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of modification of albumin on tolbutamide-serum albumin binding .
7318045	0	albumin	55,62	albumin	26,33	albumin	albumin	213	213	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of modification of albumin on tolbutamide-serum albumin binding .
46623	0	albumin	57,64	alpha-fetoprotein	29,46	albumin	alpha-fetoprotein	11657(Tax:10090)	11576(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	Immunohistochemical study of alpha-fetoprotein and serum albumin in the early postnatal period in mice .
78517	0	albumin	21,28	beta2-microglobulin	29,48	albumin	beta2-microglobulin	213	567	Gene	Gene	chains|compound|START_ENTITY chains|amod|END_ENTITY	Urinary excretion of albumin beta2-microglobulin and free light chains during lithium treatment .
6186950	0	albumin	50,57	nerve_growth_factor	20,39	albumin	nerve growth factor	11657(Tax:10090)	18049(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|transport transport|nmod|END_ENTITY	Axonal transport of nerve_growth_factor and serum albumin in the dystrophic_mouse .
20845058	0	albumin	44,51	tPA	32,35	albumin	tPA	213	5327	Gene	Gene	START_ENTITY|nsubj|IL-6 IL-6|appos|END_ENTITY	Gingival crevicular fluid IL-6 , tPA , PAI-2 , albumin levels following initial periodontal treatment in chronic_periodontitis patients with or without type 2 diabetes .
821528	0	albumin	39,46	vitellogenin	16,28	albumin	vitellogenin	396197(Tax:9031)	424533(Tax:9031)	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of vitellogenin and serum albumin in hepatic parenchymal cells of normal and estradiol-treated immature chickens .
7497088	0	alcohol_dehydrogenase	27,48	ADH	50,53	alcohol dehydrogenase	ADH	78959(Tax:10116)	78959(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effect of endotoxin on alcohol_dehydrogenase -LRB- ADH -RRB- activity in the serum of ethanol intoxicated rats .
22144473	0	alcohol_dehydrogenase	21,42	ADH1B	51,56	alcohol dehydrogenase	ADH1B	124	125	Gene	Gene	START_ENTITY|appos|ADH1A ADH1A|dep|END_ENTITY	Genetic variation in alcohol_dehydrogenase -LRB- ADH1A , ADH1B , ADH1C , ADH7 -RRB- and aldehyde_dehydrogenase -LRB- ALDH2 -RRB- , alcohol consumption and gastric_cancer risk in the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- cohort .
11527411	0	alcohol_dehydrogenase	28,49	ADH3	51,55	alcohol dehydrogenase	ADH3	116517(Tax:7955)	116517(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of alcohol_dehydrogenase -LRB- ADH3 -RRB- in zebrafish -LRB- Danio_rerio -RRB- .
19182438	0	alcohol_dehydrogenase	59,80	ADH4	82,86	alcohol dehydrogenase	ADH4	127	127	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the promoter region of the human class II alcohol_dehydrogenase -LRB- ADH4 -RRB- gene affect both transcriptional activity and ethanol metabolism in Japanese subjects .
1881901	0	alcohol_dehydrogenase	8,29	ADH6	36,40	alcohol dehydrogenase	ADH6	10327	130	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A human alcohol_dehydrogenase gene -LRB- ADH6 -RRB- encoding an additional class of isozyme .
16180008	0	alcohol_dehydrogenase	62,83	ADH7	93,97	alcohol dehydrogenase	ADH7	10327	131	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Identification of new single nucleotid polymorphisms -LRB- SNP -RRB- in alcohol_dehydrogenase class IV ADH7 gene within a French population .
22144473	0	alcohol_dehydrogenase	21,42	ADH7	65,69	alcohol dehydrogenase	ADH7	124	131	Gene	Gene	START_ENTITY|appos|ADH1A ADH1A|dep|END_ENTITY	Genetic variation in alcohol_dehydrogenase -LRB- ADH1A , ADH1B , ADH1C , ADH7 -RRB- and aldehyde_dehydrogenase -LRB- ALDH2 -RRB- , alcohol consumption and gastric_cancer risk in the European Prospective Investigation into Cancer and Nutrition -LRB- EPIC -RRB- cohort .
8082805	0	alcohol_dehydrogenase	47,68	ADH7	75,79	alcohol dehydrogenase	ADH7	10327	131	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of a class IV human alcohol_dehydrogenase gene -LRB- ADH7 -RRB- .
14562961	0	alcohol_dehydrogenase	42,63	Adh	70,73	alcohol dehydrogenase	Adh	106621041	106621041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exploring the evolutionary history of the alcohol_dehydrogenase gene -LRB- Adh -RRB- duplication in species of the family tephritidae .
6328449	0	alcohol_dehydrogenase	26,47	Adh1	49,53	alcohol dehydrogenase	Adh1	542363(Tax:4577)	542363(Tax:4577)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the alcohol_dehydrogenase -LRB- Adh1 -RRB- gene of maize .
11414683	0	alcohol_dehydrogenase	30,51	STAT5b	10,16	alcohol dehydrogenase	STAT5b	78959(Tax:10116)	25126(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of STAT5b on rat liver alcohol_dehydrogenase .
1558299	0	alcohol_dehydrogenase	16,37	aldehyde_dehydrogenase	61,83	alcohol dehydrogenase	aldehyde dehydrogenase	78959(Tax:10116)	25375(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of alcohol_dehydrogenase and the low Km form of aldehyde_dehydrogenase in isolated perivenous and periportal hepatocytes in rats .
7992014	1	alcohol_dehydrogenase	93,114	cytochrome_P450IIE1_and_catalase	116,148	alcohol dehydrogenase	cytochrome P450IIE1 and catalase	10327	847	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	I. Metabolism of ethanol by alcohol_dehydrogenase , cytochrome_P450IIE1_and_catalase -RSB- .
3793013	0	alcohol_dehydrogenase	28,49	growth_hormone	10,24	alcohol dehydrogenase	growth hormone	78959(Tax:10116)	81668(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of growth_hormone on alcohol_dehydrogenase activity in hepatocyte culture .
2164356	0	alcohol_dehydrogenase	46,67	insulin-like_growth_factor_I	10,38	alcohol dehydrogenase	insulin-like growth factor I	78959(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin-like_growth_factor_I on rat alcohol_dehydrogenase in primary hepatocyte culture .
16236269	0	alcohol_dehydrogenase	26,47	leptin	10,16	alcohol dehydrogenase	leptin	10327	3952	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of leptin on liver alcohol_dehydrogenase .
23891545	0	alcohol_dehydrogenase-1	16,39	ADH1	41,45	alcohol dehydrogenase-1	ADH1	124	124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of the alcohol_dehydrogenase-1 -LRB- ADH1 -RRB- gene in the pathomechanism of uterine_leiomyoma .
8973327	0	alcohol_dehydrogenase-1	75,98	Adh-1	100,105	alcohol dehydrogenase-1	Adh-1	11522(Tax:10090)	11522(Tax:10090)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Ten kilobases of 5 ' - flanking region confers proper regulation of the mouse alcohol_dehydrogenase-1 -LRB- Adh-1 -RRB- gene in kidney and adrenal of transgenic_mice .
8018987	0	alcohol_dehydrogenase_1	44,67	Adh-1	69,74	alcohol dehydrogenase 1	Adh-1	11522(Tax:10090)	11522(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Stage and tissue-specific expression of the alcohol_dehydrogenase_1 -LRB- Adh-1 -RRB- gene during mouse development .
12095699	0	alcohol_dehydrogenase_1	100,123	Adh1	125,129	alcohol dehydrogenase 1	Adh1	11522(Tax:10090)	11522(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Distal and proximal cis-linked sequences are needed for the total expression phenotype of the mouse alcohol_dehydrogenase_1 -LRB- Adh1 -RRB- gene .
16153155	0	alcohol_dehydrogenase_1A	40,64	ADH1A	66,71	alcohol dehydrogenase 1A	ADH1A	124	124	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	GATA-2_and_HNF-3beta regulate the human alcohol_dehydrogenase_1A -LRB- ADH1A -RRB- gene .
12489990	0	alcohol_dehydrogenase_1C	72,96	ADH1C	98,103	alcohol dehydrogenase 1C	ADH1C	126	126	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A retroviral repetitive element confers tissue-specificity to the human alcohol_dehydrogenase_1C -LRB- ADH1C -RRB- gene .
15643610	0	alcohol_dehydrogenase_1C	60,84	ADH1C	86,91	alcohol dehydrogenase 1C	ADH1C	126	126	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Natural haplotypes in the regulatory sequences affect human alcohol_dehydrogenase_1C -LRB- ADH1C -RRB- gene expression .
26221330	0	alcohol_dehydrogenase_2	24,47	ADH2	49,53	alcohol dehydrogenase 2	ADH2	125	125	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphism in alcohol_dehydrogenase_2 -LRB- ADH2 -RRB- gene and alcoholic_liver_cirrhosis risk .
26221330	0	alcohol_dehydrogenase_2	24,47	ADH2	49,53	alcohol dehydrogenase 2	ADH2	125	125	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphism in alcohol_dehydrogenase_2 -LRB- ADH2 -RRB- gene and alcoholic_liver_cirrhosis risk .
2987807	0	alcohol_dehydrogenase_2	26,49	Adh2	51,55	alcohol dehydrogenase 2	Adh2	542364(Tax:4577)	542364(Tax:4577)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the alcohol_dehydrogenase_2 -LRB- Adh2 -RRB- gene of maize .
11740346	0	alcohol_dehydrogenase_3	31,54	ADH3	56,60	alcohol dehydrogenase 3	ADH3	128	128	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Functional polymorphism in the alcohol_dehydrogenase_3 -LRB- ADH3 -RRB- promoter .
11916005	0	alcohol_dehydrogenase_4	55,78	ADH4	80,84	alcohol dehydrogenase 4	ADH4	127	127	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thirteen single-nucleotide polymorphisms -LRB- SNPs -RRB- in the alcohol_dehydrogenase_4 -LRB- ADH4 -RRB- gene locus .
19925625	0	alcohol_dehydrogenase_4	40,63	ADH4	65,69	alcohol dehydrogenase 4	ADH4	127	127	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cluster_headache is associated with the alcohol_dehydrogenase_4 -LRB- ADH4 -RRB- gene .
10780262	0	aldehyde_dehydrogenase	11,33	ALDH	35,39	aldehyde dehydrogenase	ALDH	11670(Tax:10090)	11670(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Eukaryotic aldehyde_dehydrogenase -LRB- ALDH -RRB- genes : human polymorphisms , and recommended nomenclature based on divergent evolution and chromosomal mapping .
2053494	0	aldehyde_dehydrogenase	8,30	ALDH	32,36	aldehyde dehydrogenase	ALDH	25375(Tax:10116)	25375(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of aldehyde_dehydrogenase -LRB- ALDH -RRB- in the detoxication of cyclophosphamide -LRB- CP -RRB- in rat embryos .
3189338	0	aldehyde_dehydrogenase	132,154	ALDH1	161,166	aldehyde dehydrogenase	ALDH1	217	216	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver_diseases : a strong association of the usual Caucasian-type aldehyde_dehydrogenase gene -LRB- ALDH1 -LRB- 2 -RRB- -RRB- with the disease .
10627091	0	aldehyde_dehydrogenase	60,82	ALDH2	84,89	aldehyde dehydrogenase	ALDH2	217	217	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hangover_symptoms in Asian Americans with variations in the aldehyde_dehydrogenase -LRB- ALDH2 -RRB- gene .
7779080	0	aldehyde_dehydrogenase	10,32	ALDH5	39,44	aldehyde dehydrogenase	ALDH5	217	219	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The novel aldehyde_dehydrogenase gene , ALDH5 , encodes an active aldehyde_dehydrogenase enzyme .
1558299	0	aldehyde_dehydrogenase	61,83	alcohol_dehydrogenase	16,37	aldehyde dehydrogenase	alcohol dehydrogenase	25375(Tax:10116)	78959(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of alcohol_dehydrogenase and the low Km form of aldehyde_dehydrogenase in isolated perivenous and periportal hepatocytes in rats .
20364586	0	aldehyde_dehydrogenase-2	21,45	cytochrome_P450_2E1	46,65	aldehyde dehydrogenase-2	cytochrome P450 2E1	217	1571	Gene	Gene	Association|nmod|START_ENTITY Association|dep|polymorphism polymorphism|amod|END_ENTITY	-LSB- Association between aldehyde_dehydrogenase-2 / cytochrome_P450_2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular_carcinoma -RSB- .
25264884	0	aldehyde_dehydrogenase-2	74,98	extracellular_superoxide_dismutase	38,72	aldehyde dehydrogenase-2	extracellular superoxide dismutase	217	6649	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Correlations between polymorphisms of extracellular_superoxide_dismutase , aldehyde_dehydrogenase-2 genes , as well as drinking behavior and pancreatic_cancer .
8244338	0	aldehyde_dehydrogenase-5	63,87	ALDH5	89,94	aldehyde dehydrogenase-5	ALDH5	219	219	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Diverse polymorphism within a short coding region of the human aldehyde_dehydrogenase-5 -LRB- ALDH5 -RRB- gene .
21231983	0	aldehyde_dehydrogenase_1	14,38	ALDH1	40,45	aldehyde dehydrogenase 1	ALDH1	216	216	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of aldehyde_dehydrogenase_1 -LRB- ALDH1 -RRB- in endometrioid_adenocarcinoma and its clinical implications .
26705040	0	aldehyde_dehydrogenase_1A1	6,32	ALDH1A1	34,41	aldehyde dehydrogenase 1A1	ALDH1A1	216	216	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- High aldehyde_dehydrogenase_1A1 -LRB- ALDH1A1 -RRB- expression correlated with risk of lymph_node_metastasis in papillary_thyroid_carcinoma -RSB- .
19651241	0	aldehyde_dehydrogenase_1A2	100,126	Aldh1A2	128,135	aldehyde dehydrogenase 1A2	Aldh1A2	100049450(Tax:8090)	100049450(Tax:8090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Ethanol disrupts chondrification of the neurocranial cartilages in medaka embryos without affecting aldehyde_dehydrogenase_1A2 -LRB- Aldh1A2 -RRB- promoter methylation .
17526768	0	aldehyde_dehydrogenase_1A3	23,49	ALDH1A3	51,58	aldehyde dehydrogenase 1A3	ALDH1A3	220	220	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Androgen regulation of aldehyde_dehydrogenase_1A3 -LRB- ALDH1A3 -RRB- in the androgen-responsive human prostate_cancer cell line LNCaP .
21176222	0	aldehyde_dehydrogenase_1a1	27,53	ALDH1	55,60	aldehyde dehydrogenase 1a1	ALDH1	216	216	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of aldehyde_dehydrogenase_1a1 -LRB- ALDH1 -RRB- in normal ovary_and_serous_ovarian_tumors .
15329927	0	aldehyde_dehydrogenase_2	44,68	ALDH2	70,75	aldehyde dehydrogenase 2	ALDH2	217	217	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphism detection in aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- gene using bacterial magnetic particles based on dissociation curve analysis .
18776700	0	aldehyde_dehydrogenase_2	28,52	ALDH2	54,59	aldehyde dehydrogenase 2	ALDH2	217	217	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Genetic association between aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- variation and high-density lipoprotein cholesterol -LRB- HDL-C -RRB- among non-drinkers in two large population samples in Japan .
1916152	0	aldehyde_dehydrogenase_2	18,42	ALDH2	44,49	aldehyde dehydrogenase 2	ALDH2	217	217	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotyping of the aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- gene using the polymerase chain reaction : evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency .
19914339	0	aldehyde_dehydrogenase_2	26,50	ALDH2	52,57	aldehyde dehydrogenase 2	ALDH2	217	217	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Absence of association on aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- polymorphism with Mongolian Alzheimer patients .
22870576	0	aldehyde_dehydrogenase_2	18,42	ALDH2	44,49	aldehyde dehydrogenase 2	ALDH2	217	217	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of an aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- gene polymorphism with hyper-low-density_lipoprotein_cholesterolemia in a Japanese population .
17312945	0	aldehyde_dehydrogenase_2	55,79	aldh2b	86,92	aldehyde dehydrogenase 2	aldh2b	393462(Tax:7955)	368239(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and expression of a second zebrafish aldehyde_dehydrogenase_2 gene -LRB- aldh2b -RRB- .
11811951	0	aldehyde_dehydrogenase_2	37,61	hepatocyte_nuclear_factor_4	74,101	aldehyde dehydrogenase 2	hepatocyte nuclear factor 4	217	3172	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Transcriptional control of the human aldehyde_dehydrogenase_2 promoter by hepatocyte_nuclear_factor_4 : inhibition by cyclic AMP and COUP transcription factors .
9765594	0	aldehyde_dehydrogenase_2	36,60	hepatocyte_nuclear_factor_4	73,100	aldehyde dehydrogenase 2	hepatocyte nuclear factor 4	217	25735(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Binding and activation of the human aldehyde_dehydrogenase_2 promoter by hepatocyte_nuclear_factor_4 .
25807426	0	aldehyde_dehydrogenase_2	60,84	miR-28	0,6	aldehyde dehydrogenase 2	miR-28	11669(Tax:10090)	723830(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-28 promotes cardiac_ischemia by targeting mitochondrial aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- in mus_musculus cardiac myocytes .
24996175	0	aldehyde_oxidase	28,44	AOX1	46,50	aldehyde oxidase	AOX1	11761(Tax:10090)	11761(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expressional studies of the aldehyde_oxidase -LRB- AOX1 -RRB- gene during myogenic differentiation in C2C12 cells .
10975464	0	aldehyde_oxidase	24,40	hAOX1	42,47	aldehyde oxidase	hAOX1	51	316	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Activation of the human aldehyde_oxidase -LRB- hAOX1 -RRB- promoter by tandem cooperative Sp1/Sp3 binding sites : identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter , distal activation sites , and a silencer element .
11562361	0	aldehyde_oxidase_homolog_1	20,46	AOH1	48,52	aldehyde oxidase homolog 1	AOH1	71724(Tax:10090)	71724(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Purification of the aldehyde_oxidase_homolog_1 -LRB- AOH1 -RRB- protein and cloning of the AOH1 and aldehyde_oxidase_homolog_2 -LRB- AOH2 -RRB- genes .
11562361	0	aldehyde_oxidase_homolog_2	90,116	AOH2	118,122	aldehyde oxidase homolog 2	AOH2	71872(Tax:10090)	71872(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Purification of the aldehyde_oxidase_homolog_1 -LRB- AOH1 -RRB- protein and cloning of the AOH1 and aldehyde_oxidase_homolog_2 -LRB- AOH2 -RRB- genes .
14667815	0	aldehyde_reductase	14,32	STAF	47,51	aldehyde reductase	STAF	10327	7702	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of aldehyde_reductase expression by STAF and CHOP .
17312945	0	aldh2b	86,92	aldehyde_dehydrogenase_2	55,79	aldh2b	aldehyde dehydrogenase 2	368239(Tax:7955)	393462(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning and expression of a second zebrafish aldehyde_dehydrogenase_2 gene -LRB- aldh2b -RRB- .
20338228	0	aldo-keto_reductase_1C1	101,124	AKR1C1	126,132	aldo-keto reductase 1C1	AKR1C1	1645	1645	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The CCAAT box binding transcription factor , nuclear factor-Y -LRB- NF-Y -RRB- regulates transcription of human aldo-keto_reductase_1C1 -LRB- AKR1C1 -RRB- gene .
26308156	0	aldo-keto_reductase_1C3	12,35	AKR1C3	37,43	aldo-keto reductase 1C3	AKR1C3	8644	8644	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of aldo-keto_reductase_1C3 -LRB- AKR1C3 -RRB- - mediated prostaglandin_D2 -LRB- PGD2 -RRB- metabolism in keloids .
22222635	0	aldo-keto_reductase_family_1B10	41,72	AKR1B10	74,81	aldo-keto reductase family 1B10	AKR1B10	57016	57016	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Overexpression and oncogenic function of aldo-keto_reductase_family_1B10 -LRB- AKR1B10 -RRB- in pancreatic_carcinoma .
22014308	0	aldo-keto_reductase_family_1_member_C1	14,52	AKR1C1	54,60	aldo-keto reductase family 1 member C1	AKR1C1	733634(Tax:9823)	733634(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of aldo-keto_reductase_family_1_member_C1 -LRB- AKR1C1 -RRB- gene in porcine ovary and uterine endometrium during the estrous cycle and pregnancy .
24303814	0	aldo-keto_reductase_family_1_member_C1	31,69	AKR1C1	71,77	aldo-keto reductase family 1 member C1	AKR1C1	733634(Tax:9823)	733634(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Flutamide influences placental aldo-keto_reductase_family_1_member_C1 -LRB- AKR1C1 -RRB- expression in pigs .
1956774	0	aldolase_B	87,97	HNF1	71,75	aldolase B	HNF1	24190(Tax:10116)	24817(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Interplay of an original combination of factors : C/EBP , NFY , HNF3 , and HNF1 in the rat aldolase_B gene promoter .
11306079	0	aldose_reductase	48,64	thioredoxin	33,44	aldose reductase	thioredoxin	616199(Tax:9913)	280950(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effect of bovine small intestine thioredoxin on aldose_reductase activity .
11145742	0	aldose_reductase-like	214,235	AKR1B7	242,248	aldose reductase-like	AKR1B7	102642655	11997(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SF-1 _ -LRB- steroidogenic_factor-1 -RRB- , C/EBPbeta -LRB- CCAAT/enhancer binding protein -RRB- , and ubiquitous transcription factors NF1 _ -LRB- nuclear_factor_1 -RRB- and Sp1 -LRB- selective_promoter_factor_1 -RRB- are required for regulation of the mouse aldose_reductase-like gene -LRB- AKR1B7 -RRB- expression in adrenocortical cells .
12914526	0	aldose_reductase-like	51,72	akr1b7	78,84	aldose reductase-like	akr1b7	102642655	11997(Tax:10090)	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Hormonal and developmental regulation of the mouse aldose_reductase-like gene akr1b7 expression in Leydig cells .
14693054	0	aldose_reductase_like_gene-1	86,114	ARL-1	116,121	aldose reductase like gene-1	ARL-1	400	400	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Screening of the drug resistance-associated gene in HepG2 cell line transfected with aldose_reductase_like_gene-1 -LRB- ARL-1 -RRB- -RSB- .
10577993	0	aldosterone_synthase	20,40	CYP11B2	42,49	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Joint effects of an aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism and classic risk factors on risk of myocardial_infarction .
10720582	0	aldosterone_synthase	18,38	CYP11B2	40,47	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of the aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism in patients with myocardial_infarction .
11422117	0	aldosterone_synthase	33,53	CYP11B2	60,67	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An influence of variation in the aldosterone_synthase gene -LRB- CYP11B2 -RRB- on corticosteroid responses to ACTH in normal human subjects .
11701710	0	aldosterone_synthase	60,80	CYP11B2	82,89	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Congenital hyperreninemic_hypoaldosteronism unlinked to the aldosterone_synthase -LRB- CYP11B2 -RRB- gene .
11728005	0	aldosterone_synthase	14,34	CYP11B2	36,43	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotypes of aldosterone_synthase -LRB- CYP11B2 -RRB- gene in the general population of Japan : the Ohasama study .
12433910	0	aldosterone_synthase	20,40	CYP11B2	42,49	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism and left ventricular volume in patients with dilated_cardiomyopathy .
12750023	0	aldosterone_synthase	32,52	CYP11B2	23,30	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of selective CYP11B2 -LRB- aldosterone_synthase -RRB- inhibitors for the therapy of congestive_heart_failure and myocardial_fibrosis .
12817181	0	aldosterone_synthase	22,42	CYP11B2	49,56	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|compound|END_ENTITY	Haplotype analysis of aldosterone_synthase gene -LRB- CYP11B2 -RRB- polymorphisms shows association with essential hypertension .
14736447	0	aldosterone_synthase	20,40	CYP11B2	42,49	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between aldosterone_synthase -LRB- CYP11B2 -RRB- polymorphism and left ventricular mass in human essential hypertension .
15223724	0	aldosterone_synthase	24,44	CYP11B2	59,66	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Association of -344 / T/C aldosterone_synthase polymorphism -LRB- CYP11B2 -RRB- with left ventricular structure and humoral parameters in young normotensive men .
15230231	0	aldosterone_synthase	22,42	CYP11B2	49,56	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Promoter variants of aldosterone_synthase gene -LRB- CYP11B2 -RRB- and salt-sensitivity of blood pressure -RSB- .
1594605	0	aldosterone_synthase	32,52	CYP11B2	23,30	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in the human CYP11B2 -LRB- aldosterone_synthase -RRB- gene causing corticosterone methyloxidase II deficiency .
17261471	0	aldosterone_synthase	39,59	CYP11B2	66,73	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-344 C/T Variant in the promoter of the aldosterone_synthase gene -LRB- CYP11B2 -RRB- is associated with metabolic_syndrome in men .
18202594	0	aldosterone_synthase	45,65	CYP11B2	72,79	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The role of the -344 C/T polymorphism of the aldosterone_synthase gene -LRB- CYP11B2 -RRB- in cardiovascular_diseases -RSB- .
18710464	0	aldosterone_synthase	36,56	CYP11B2	58,65	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of genetic variation in the aldosterone_synthase -LRB- CYP11B2 -RRB- gene on enzyme function .
19407459	0	aldosterone_synthase	20,40	CYP11B2	41,48	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Association between aldosterone_synthase CYP11B2 polymorphism and essential hypertension in Chinese : a meta-analysis .
21092623	0	aldosterone_synthase	16,36	CYP11B2	38,45	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	-LSB- Association of aldosterone_synthase -LRB- CYP11B2 -RRB- gene -344 T/C polymorphism with essential hypertension in Mongolian nationality -RSB- .
23681285	0	aldosterone_synthase	15,35	CYP11B2	37,44	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of aldosterone_synthase -LRB- CYP11B2 -RRB- gene -344 T/C polymorphism with the risk of primary chronic glomerulonephritis in the Polish population .
25143332	0	aldosterone_synthase	15,35	CYP11B2	37,44	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of aldosterone_synthase -LRB- CYP11B2 -RRB- gene polymorphism with IgA_nephropathy risk and progression of IgA_nephropathy .
25785110	0	aldosterone_synthase	27,47	CYP11B2	48,55	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Associations between human aldosterone_synthase CYP11B2 -LRB- -344 T/C -RRB- gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension .
9745430	0	aldosterone_synthase	89,109	CYP11B2	111,118	aldosterone synthase	CYP11B2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Familial_hyperaldosteronism_type_II : description of a large kindred and exclusion of the aldosterone_synthase -LRB- CYP11B2 -RRB- gene .
22465514	0	aldosterone_synthase	78,98	Cyp11b2	100,107	aldosterone synthase	Cyp11b2	1585	1585	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A case of primary selective_hypoaldosteronism carrying three mutations in the aldosterone_synthase -LRB- Cyp11b2 -RRB- gene .
17929852	0	alien	56,61	p33ING1	22,29	alien	p33ING1	9318	3621	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing .
16567122	0	alkaline_phosphatase	22,42	ALP	44,47	alkaline phosphatase	ALP	250	250	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression of alkaline_phosphatase -LRB- ALP -RRB- in the liver of primary_biliary_cirrhosis -LRB- PBC -RRB- patients .
11786925	0	alkaline_phosphatase	14,34	FKHR	86,90	alkaline phosphatase	FKHR	250	2308	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of alkaline_phosphatase promoter activity by forkhead transcription factor FKHR .
11275953	0	alkaline_phosphatase	54,74	IGF-I	16,21	alkaline phosphatase	IGF-I	250	3479	Gene	Gene	START_ENTITY|nsubj|decrease decrease|nmod|END_ENTITY	The decrease of IGF-I , IGF-binding_protein-3 and bone alkaline_phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac_disease .
8653285	0	alkaline_phosphatase	26,46	PLAP	48,52	alkaline phosphatase	PLAP	250	250	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of placental alkaline_phosphatase -LRB- PLAP -RRB- in the monitoring of patients with seminoma .
20004646	0	alkaline_phosphatase	38,58	Tumor_necrosis_factor-alpha	0,27	alkaline phosphatase	Tumor necrosis factor-alpha	250	7124	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Tumor_necrosis_factor-alpha increases alkaline_phosphatase expression in vascular smooth muscle cells via MSX2 induction .
23749297	0	alkaline_phosphatase	26,46	bFGF	0,4	alkaline phosphatase	bFGF	250	2247	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	bFGF and JAGGED1 regulate alkaline_phosphatase expression and mineralization in dental tissue-derived mesenchymal stem cells .
8222965	0	alkaline_phosphatase	51,71	interleukin-1_beta	11,29	alkaline phosphatase	interleukin-1 beta	250	3553	Gene	Gene	mRNA|amod|START_ENTITY END_ENTITY|nmod|mRNA	-LSB- Effect of interleukin-1_beta on liver/bone/kidney alkaline_phosphatase mRNA level of fibroblastic cells derived from human periodontal ligament -RSB- .
8071580	0	alkaline_phosphatase	17,37	pyrophosphatase	38,53	alkaline phosphatase	pyrophosphatase	250	5464	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Implications of alkaline_phosphatase pyrophosphatase activity : intracellular functions of alkaline_phosphatase -RSB- .
8071580	0	alkaline_phosphatase	91,111	pyrophosphatase	38,53	alkaline phosphatase	pyrophosphatase	250	5464	Gene	Gene	-RSB-|amod|START_ENTITY functions|nmod|-RSB- Implications|dep|functions Implications|nmod|activity activity|compound|END_ENTITY	-LSB- Implications of alkaline_phosphatase pyrophosphatase activity : intracellular functions of alkaline_phosphatase -RSB- .
19449863	0	alkyladenine_DNA_glycosylase	70,98	AP_endonuclease_1	6,23	alkyladenine DNA glycosylase	AP endonuclease 1	4350	328	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Human AP_endonuclease_1 stimulates multiple-turnover base excision by alkyladenine_DNA_glycosylase .
25514475	0	allergic_rhinitis	25,42	IL-22	10,15	allergic rhinitis	IL-22	260328	50616	Gene	Gene	level|nmod|START_ENTITY level|compound|END_ENTITY	Increased IL-22 level in allergic_rhinitis significantly correlates with clinical severity .
20850992	0	allograft_inflammatory_factor-1	14,45	AIF-1	47,52	allograft inflammatory factor-1	AIF-1	199	199	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of allograft_inflammatory_factor-1 -LRB- AIF-1 -RRB- in acute cellular rejection of cardiac allografts .
16868985	0	allograft_inflammatory_factor_1	14,45	transforming_growth_factor_beta	163,194	allograft inflammatory factor 1	transforming growth factor beta	199	7040	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of allograft_inflammatory_factor_1 in tissues from patients with systemic_sclerosis and in vitro differential expression of its isoforms in response to transforming_growth_factor_beta .
12723015	0	alpha-1	109,116	beta-1	122,128	alpha-1	beta-1	146	3779	Gene	Gene	START_ENTITY|nmod|blockade blockade|amod|END_ENTITY	Adjunctive sympathoplegic therapy to ACE inhibition in Blacks with congestive_heart_failure : a comparison of alpha-1 with beta-1 blockade on exercise tolerance and cardiac sympathovagal reflex activity .
1980144	0	alpha-1	13,20	corticotropin-releasing_factor	68,98	alpha-1	corticotropin-releasing factor	146	1392	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Differential alpha-1 and alpha-2 adrenergic effects on hypothalamic corticotropin-releasing_factor and plasma adrenocorticotropin .
7985993	0	alpha-1-B-glycoprotein	23,45	A1BG	47,51	alpha-1-B-glycoprotein	A1BG	1	1	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of plasma alpha-1-B-glycoprotein -LRB- A1BG -RRB- polymorphism in several populations of the Indian subcontinent .
9862866	0	alpha-1-acid_glycoprotein	34,59	Growth_hormone	0,14	alpha-1-acid glycoprotein	Growth hormone	24614(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Growth_hormone inhibits rat liver alpha-1-acid_glycoprotein gene expression in vivo and in vitro .
16968986	0	alpha-1-antichymotrypsin	42,66	SERPINA3	68,76	alpha-1-antichymotrypsin	SERPINA3	12	12	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The alanine/threonine polymorphism of the alpha-1-antichymotrypsin -LRB- SERPINA3 -RRB- gene and ruptured intracranial_aneurysms in the Japanese population .
2379100	0	alpha-1-antitrypsin	80,99	Alpha-1-antitrypsin	0,19	alpha-1-antitrypsin	Alpha-1-antitrypsin	5265	5265	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Alpha-1-antitrypsin in the renal tubular epithelium in patients with or without alpha-1-antitrypsin deficiency .
7043719	0	alpha-1-antitrypsin	9,28	transferrin	32,43	alpha-1-antitrypsin	transferrin	5265	7018	Gene	Gene	Ratio|nmod|START_ENTITY Ratio|acl|END_ENTITY	Ratio of alpha-1-antitrypsin to transferrin in gingival fluid and in blood from patients with periodontal_disease .
19134079	0	alpha-1-fucosyltransferase	25,51	FUT1	53,57	alpha-1-fucosyltransferase	FUT1	397138(Tax:9823)	397138(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation at the alpha-1-fucosyltransferase -LRB- FUT1 -RRB- gene in Asian wild_boar and Chinese and Western commercial pig breeds .
8456628	0	alpha-1-protease_inhibitor	12,38	A1PI	40,44	alpha-1-protease inhibitor	A1PI	5265	5265	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of alpha-1-protease_inhibitor -LRB- A1PI -RRB- in the inhibition of protease activity in human knee_osteoarthritis .
20170533	0	alpha-1_antitrypsin	66,85	SERPINA1	87,95	alpha-1 antitrypsin	SERPINA1	5265	5265	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prevalence of genetic polymorphisms in the promoter region of the alpha-1_antitrypsin -LRB- SERPINA1 -RRB- gene in chronic_liver_disease : a case control study .
18954413	0	alpha-1a	26,34	TUBA1A	44,50	alpha-1a	TUBA1A	773	7846	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Refining the phenotype of alpha-1a Tubulin -LRB- TUBA1A -RRB- mutation in patients with classical_lissencephaly .
16910174	0	alpha-2-macroglobulin	32,53	A2M	55,58	alpha-2-macroglobulin	A2M	2	2	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The genetic association between alpha-2-macroglobulin -LRB- A2M -RRB- gene deletion polymorphism and low serum A2M concentration in overweight/obese Thais .
1711512	0	alpha-2-macroglobulin	10,31	C-reactive_protein	59,77	alpha-2-macroglobulin	C-reactive protein	2	1401	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of alpha-2-macroglobulin on cytokine-mediated human C-reactive_protein production .
18485748	0	alpha-2-macroglobulin	91,112	cartilage_oligomeric_matrix_protein	52,87	alpha-2-macroglobulin	cartilage oligomeric matrix protein	2	1311	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage_oligomeric_matrix_protein by alpha-2-macroglobulin .
74964	1	alpha-2-macroglobulin	108,129	haptoglobin	74,85	alpha-2-macroglobulin	haptoglobin	2	3240	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Immunoglobulins A , G , M , haptoglobin , alpha-1-antitrypsin , alpha-2-macroglobulin -RSB- .
4166088	0	alpha-2-macroglobulin	14,35	plasmin	63,70	alpha-2-macroglobulin	plasmin	2	5340	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of alpha-2-macroglobulin in human serum on trypsin , plasmin , and thrombin activities .
4166401	0	alpha-2-macroglobulin	34,55	plasmin	14,21	alpha-2-macroglobulin	plasmin	2	5340	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of plasmin activity by alpha-2-macroglobulin .
7545523	0	alpha-2-macroglobulin	41,62	plasmin	18,25	alpha-2-macroglobulin	plasmin	2	5340	Gene	Gene	Concentration|acl|START_ENTITY Concentration|nmod|complexes complexes|compound|END_ENTITY	-LSB- Concentration of plasmin complexes with alpha-2-macroglobulin and alpha-2-antiplasmin in blood plasma and serum -RSB- .
8622573	0	alpha-2u-globulin	40,57	alpha-2u-globulin	83,100	alpha-2u-globulin	alpha-2u-globulin	298111(Tax:10116)	298111(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of passive immunization against alpha-2u-globulin and supplementation with alpha-2u-globulin on serum gonadotrophins and testicular activity .
8622573	0	alpha-2u-globulin	83,100	alpha-2u-globulin	40,57	alpha-2u-globulin	alpha-2u-globulin	298111(Tax:10116)	298111(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY Effects|nmod|activity Effects|nmod|END_ENTITY	Effects of passive immunization against alpha-2u-globulin and supplementation with alpha-2u-globulin on serum gonadotrophins and testicular activity .
18413140	0	alpha-Actinin	0,13	zyxin	33,38	alpha-Actinin	zyxin	87	7791	Gene	Gene	links|nsubj|START_ENTITY links|dep|END_ENTITY	alpha-Actinin links LPP , but not zyxin , to cadherin-based junctions .
20534429	0	alpha-COP	21,30	epsilon-COP	47,58	alpha-COP	epsilon-COP	1314	11316	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat .
16873605	0	alpha-Calcitonin_Gene-Related_Peptide	42,79	CGRP	81,85	alpha-Calcitonin Gene-Related Peptide	CGRP	796	796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Pharmacological characterization of novel alpha-Calcitonin_Gene-Related_Peptide -LRB- CGRP -RRB- receptor peptide antagonists that are selective for human CGRP receptors .
19941816	0	alpha-Catenin	67,80	beta-Catenin	122,134	alpha-Catenin	beta-Catenin	1495	1499	Gene	Gene	disassociation|nmod|START_ENTITY promotes|dobj|disassociation promotes|nmod|beta-Catenin beta-Catenin|nmod|END_ENTITY	EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin .
19941816	0	alpha-Catenin	67,80	beta-Catenin	86,98	alpha-Catenin	beta-Catenin	1495	1499	Gene	Gene	disassociation|nmod|START_ENTITY promotes|dobj|disassociation promotes|nmod|END_ENTITY	EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin .
9023354	0	alpha-E-catenin	3,18	trap	24,28	alpha-E-catenin	trap	12385(Tax:10090)	11433(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	An alpha-E-catenin gene trap mutation defines its function in preimplantation development .
12509712	0	alpha-L-iduronidase	94,113	IDUA	115,119	alpha-L-iduronidase	IDUA	3425	3425	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Diversity of mutations and distribution of single nucleotide polymorphic alleles in the human alpha-L-iduronidase -LRB- IDUA -RRB- gene .
1362562	0	alpha-L-iduronidase	44,63	IDUA	65,69	alpha-L-iduronidase	IDUA	3425	3425	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	PCR detection of two RFLPs in exon I of the alpha-L-iduronidase -LRB- IDUA -RRB- gene .
9536518	0	alpha-L-iduronidase	6,25	IDUA	27,31	alpha-L-iduronidase	IDUA	3425	3425	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human alpha-L-iduronidase -LRB- IDUA -RRB- gene : correlation of polymorphic DNA haplotype and IDUA activity in Chinese population .
9700243	0	alpha-L-iduronidase	6,25	IDUA	27,31	alpha-L-iduronidase	IDUA	3425	3425	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human alpha-L-iduronidase -LRB- IDUA -RRB- gene : apparent recombination in intron 2 by haplotype analysis in a Taiwanese population .
10329427	0	alpha-MSH	63,72	AGRP	48,52	alpha-MSH	AGRP	24664(Tax:10116)	25582(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in hypothalamic agouti-related_protein -LRB- AGRP -RRB- , but not alpha-MSH or pro-opiomelanocortin concentrations in dietary-obese and food-restricted rats .
2952856	0	alpha-MSH	58,67	Atrial_natriuretic_factor	0,25	alpha-MSH	Atrial natriuretic factor	5443	4878	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Atrial_natriuretic_factor -LRB- ANF -RRB- stimulates the release of alpha-MSH from frog neurointermediate lobes in vitro .
18388300	0	alpha-MSH	16,25	MC1r	56,60	alpha-MSH	MC1r	18976(Tax:10090)	17199(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264 .7 macrophages .
19889022	0	alpha-MSH	48,57	alpha-melanocyte-stimulating_hormone	10,46	alpha-MSH	alpha-melanocyte-stimulating hormone	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Increased alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic_dermatitis .
2828246	0	alpha-MSH	51,60	alpha-melanocyte-stimulating_hormone	13,49	alpha-MSH	alpha-melanocyte-stimulating hormone	5443	5443	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Evidence for alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- receptors on human malignant_melanoma cells .
3516302	0	alpha-MSH	73,82	alpha-melanocyte-stimulating_hormone	35,71	alpha-MSH	alpha-melanocyte-stimulating hormone	5443	5443	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and identification of alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- in the frog brain .
6297686	0	alpha-MSH	87,96	alpha-melanocyte-stimulating_hormone	49,85	alpha-MSH	alpha-melanocyte-stimulating hormone	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biological and immunological characterization of alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- in two neuronal systems of the rat brain .
11093286	0	alpha-MSH	64,73	alpha-melanocyte_stimulating_hormone	26,62	alpha-MSH	alpha-melanocyte stimulating hormone	5443	5443	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated plasma levels of alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- are correlated with insulin resistance in obese men .
99212	0	alpha-MSH	74,83	alpha-melanocyte_stimulating_hormone	36,72	alpha-MSH	alpha-melanocyte stimulating hormone	5443	5443	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- in the human hypothalamus .
165218	0	alpha-MSH	14,23	growth_hormone	34,48	alpha-MSH	growth hormone	5443	2688	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of alpha-MSH on plasma growth_hormone , cortisol and TSH in children .
10223286	0	alpha-MSH	11,20	interleukin-1beta	91,108	alpha-MSH	interleukin-1beta	24664(Tax:10116)	24494(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Endogenous alpha-MSH modulates the hypothalamic-pituitary-adrenal response to the cytokine interleukin-1beta .
17683952	0	alpha-MSH	0,9	matrix_metalloproteinase-13	37,64	alpha-MSH	matrix metalloproteinase-13	5443	4322	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	alpha-MSH inhibits TNF-alpha-induced matrix_metalloproteinase-13 expression by modulating p38 kinase and nuclear factor kappaB signaling in human chondrosarcoma HTB-94 cells .
9045742	0	alpha-MSH	0,9	tumor_necrosis_factor-alpha	42,69	alpha-MSH	tumor necrosis factor-alpha	18976(Tax:10090)	21926(Tax:10090)	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	alpha-MSH modulates local and circulating tumor_necrosis_factor-alpha in experimental brain_inflammation .
3009169	0	alpha-MSH	15,24	tyrosinase	92,102	alpha-MSH	tyrosinase	5443	7299	Gene	Gene	START_ENTITY|dep|melanotropin melanotropin|dep|activates activates|dobj|END_ENTITY	-LSB- Nle4 , D-Phe7 -RSB- - alpha-MSH : a superpotent melanotropin that `` irreversibly '' activates melanoma tyrosinase .
402759	0	alpha-MSH	10,19	tyrosinase	27,37	alpha-MSH	tyrosinase	18976(Tax:10090)	22173(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of alpha-MSH on the tyrosinase activity and the rate of melanin accumulation of melanoma cells in vitro .
8789740	0	alpha-MSH	40,49	tyrosinase	77,87	alpha-MSH	tyrosinase	5443	7299	Gene	Gene	peptide|appos|START_ENTITY stimulates|nsubj|peptide stimulates|dobj|activity activity|compound|END_ENTITY	The melanotropic peptide , -LSB- Nle4,D-Phe7 -RSB- alpha-MSH , stimulates human melanoma tyrosinase activity and inhibits cell proliferation .
14572638	0	alpha-Melanocyte-stimulating_hormone	0,36	CD14	112,116	alpha-Melanocyte-stimulating hormone	CD14	5443	929	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|downregulating downregulating|dobj|END_ENTITY	alpha-Melanocyte-stimulating_hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages .
12816950	0	alpha-Melanocyte-stimulating_hormone	0,36	tumor_necrosis_factor-alpha	73,100	alpha-Melanocyte-stimulating hormone	tumor necrosis factor-alpha	5443	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	alpha-Melanocyte-stimulating_hormone inhibits lipopolysaccharide-induced tumor_necrosis_factor-alpha production in leukocytes by modulating protein kinase A , p38 kinase , and nuclear_factor_kappa_B signaling pathways .
3976723	0	alpha-N-acetyl-D-glucosaminidase	36,68	NAG	70,73	alpha-N-acetyl-D-glucosaminidase	NAG	4669	4669	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Segregation and linkage analysis of alpha-N-acetyl-D-glucosaminidase -LRB- NAG -RRB- levels in a black family .
18005096	0	alpha-SMA	27,36	TGF-beta1	178,187	alpha-SMA	TGF-beta1	25365(Tax:10116)	59086(Tax:10116)	Gene	Gene	Alpha-smooth_muscle_actin|appos|START_ENTITY Alpha-smooth_muscle_actin|dep|role role|nmod|transforming_growth_factor-beta_1 transforming_growth_factor-beta_1|appos|END_ENTITY	Alpha-smooth_muscle_actin -LRB- alpha-SMA -RRB- and nestin expression in reactive astrocytes in multiple_sclerosis lesions : potential regulatory role of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- .
18386047	0	alpha-SMA	55,64	TGF-beta1	76,85	alpha-SMA	TGF-beta1	25365(Tax:10116)	59086(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	HGF suppresses the production of collagen type III and alpha-SMA induced by TGF-beta1 in healing fibroblasts .
19762473	0	alpha-SNAP	40,50	NSF	98,101	alpha-SNAP	NSF	8775	4905	Gene	Gene	site|nmod|START_ENTITY facilitates|nsubj|site facilitates|dobj|N-ethylmaleimide-sensitive_factor N-ethylmaleimide-sensitive_factor|appos|END_ENTITY	A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive_factor -LRB- NSF -RRB- - driven SNARE complex disassembly .
8620540	0	alpha-SNAP	39,49	NSF	8,11	alpha-SNAP	NSF	8775	4905	Gene	Gene	Sec17p|appos|START_ENTITY release|nmod|Sec17p precede|nsubj|release driven|ccomp|precede Sec18p|acl|driven Sec18p|appos|END_ENTITY	Sec18p -LRB- NSF -RRB- - driven release of Sec17p -LRB- alpha-SNAP -RRB- can precede docking and fusion of yeast vacuoles .
9362506	0	alpha-SNAP	38,48	NSF	15,18	alpha-SNAP	NSF	8775	4905	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis .
16199552	0	alpha-T_catenin	24,39	VR22	46,50	alpha-T catenin	VR22	29119	29119	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interaction between the alpha-T_catenin gene -LRB- VR22 -RRB- and APOE in Alzheimer 's _ disease .
9215644	0	alpha-actin	28,39	transforming_growth_factor_beta3	126,158	alpha-actin	transforming growth factor beta3	423787(Tax:9031)	396438(Tax:9031)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of smooth muscle alpha-actin in mesenchymal cells during formation of avian endocardial cushion tissue : a role for transforming_growth_factor_beta3 .
1655973	0	alpha-actinin	14,27	Agrin	0,5	alpha-actinin	Agrin	396024(Tax:9031)	396538(Tax:9031)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Agrin induces alpha-actinin , filamin , and vinculin to co-localize with AChR clusters on cultured chick myotubes .
9314536	0	alpha-actinin	80,93	CRP1	0,4	alpha-actinin	CRP1	87	1396	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CRP1 , a LIM domain protein implicated in muscle differentiation , interacts with alpha-actinin .
17298598	0	alpha-actinin	141,154	EFA6A	32,37	alpha-actinin	EFA6A	87	5662	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Somatodendritic localization of EFA6A , a guanine_nucleotide exchange factor for ADP-ribosylation_factor_6 , and its possible interaction with alpha-actinin in dendritic spines .
17008069	0	alpha-actinin	11,24	EGFR	67,71	alpha-actinin	EGFR	31166(Tax:7227)	37455(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling .
8824270	0	alpha-actinin	83,96	ICAM-2	72,78	alpha-actinin	ICAM-2	87	3384	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of the cytoplasmic domain of intercellular_adhesion_molecule-2 -LRB- ICAM-2 -RRB- to alpha-actinin .
10401575	0	alpha-actinin	21,34	MEKK1	0,5	alpha-actinin	MEKK1	87	4214	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions .
11171996	0	alpha-actinin	13,26	Myozenin	0,8	alpha-actinin	Myozenin	87	58529	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|dep|protein	Myozenin : an alpha-actinin - and gamma-filamin-binding protein of skeletal muscle Z lines .
9030526	0	alpha-actinin	24,37	PKN	15,18	alpha-actinin	PKN	87	5585	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of PKN with alpha-actinin .
12493766	0	alpha-actinin	27,40	Syndecan-4	0,10	alpha-actinin	Syndecan-4	87	6385	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Syndecan-4 associates with alpha-actinin .
12837758	0	alpha-actinin	68,81	adenosine_A2A_receptor	4,26	alpha-actinin	adenosine A2A receptor	87	135	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The adenosine_A2A_receptor interacts with the actin-binding protein alpha-actinin .
9152027	0	alpha-actinin	59,72	alpha-catenin	40,53	alpha-actinin	alpha-catenin	87	1495	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|interactions interactions|nmod|END_ENTITY	Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin .
8943213	0	alpha-actinin	57,70	rabphilin-3A	39,51	alpha-actinin	rabphilin-3A	87	22895	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of rabphilin-3A with alpha-actinin .
10819994	0	alpha-actinin	11,24	titin	28,33	alpha-actinin	titin	87	7273	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of alpha-actinin to titin : implications for Z-disk assembly .
3320056	2	alpha-actinin	99,112	titin	125,130	alpha-actinin	titin	396024(Tax:9031)	424126(Tax:9031)	Gene	Gene	dots|amod|START_ENTITY dots|nmod|END_ENTITY	Generation of alpha-actinin dots within titin spots at the time of the first myofibril formation .
9245597	0	alpha-actinin	31,44	titin	78,83	alpha-actinin	titin	87	7273	Gene	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin : implications for the nature of vertebrate Z-discs .
9438132	0	alpha-actinin	15,28	titin	43,48	alpha-actinin	titin	87	7273	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of alpha-actinin with cellular titin .
9501083	0	alpha-actinin	113,126	titin	59,64	alpha-actinin	titin	87	7273	Gene	Gene	asymmetrical|nmod|START_ENTITY lead|nmod|asymmetrical lead|nsubj|structure structure|nmod|Z-disk Z-disk|dep|types types|nmod|interactions interactions|compound|END_ENTITY	Molecular structure of the sarcomeric Z-disk : two types of titin interactions lead to an asymmetrical sorting of alpha-actinin .
3113423	0	alpha-actinin	38,51	vinculin	24,32	alpha-actinin	vinculin	87	7414	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of vinculin with alpha-actinin .
7988684	0	alpha-actinin	48,61	vinculin	31,39	alpha-actinin	vinculin	87	7414	Gene	Gene	control|dobj|START_ENTITY control|nsubj|interactions interactions|nmod|END_ENTITY	Intramolecular interactions in vinculin control alpha-actinin binding to the vinculin head .
7988684	0	alpha-actinin	48,61	vinculin	77,85	alpha-actinin	vinculin	87	7414	Gene	Gene	control|dobj|START_ENTITY control|nmod|head head|compound|END_ENTITY	Intramolecular interactions in vinculin control alpha-actinin binding to the vinculin head .
8504798	0	alpha-actinin	43,56	vinculin	64,72	alpha-actinin	vinculin	87	7414	Gene	Gene	interaction|nmod|START_ENTITY Evidence|nmod|interaction Evidence|amod|END_ENTITY	Evidence for a ternary interaction between alpha-actinin , -LRB- meta -RRB- vinculin and acidic-phospholipid bilayers .
10224105	0	alpha-actinin	3,16	zyxin	33,38	alpha-actinin	zyxin	87	7791	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment .
10224105	0	alpha-actinin	3,16	zyxin	68,73	alpha-actinin	zyxin	87	418300(Tax:9031)	Gene	Gene	site|amod|START_ENTITY essential|nsubj|site essential|nmod|localization localization|compound|END_ENTITY	An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment .
10700177	0	alpha-actinin-4	29,44	ACTN4	13,18	alpha-actinin-4	ACTN4	81	81	Gene	Gene	Mutations|amod|START_ENTITY Mutations|nmod|END_ENTITY	Mutations in ACTN4 , encoding alpha-actinin-4 , cause familial focal segmental_glomerulosclerosis .
10673389	0	alpha-actinin-4	44,59	BERP	0,4	alpha-actinin-4	BERP	63836(Tax:10116)	83616(Tax:10116)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	BERP , a novel ring finger protein , binds to alpha-actinin-4 .
12099693	0	alpha-actinin_1	27,42	ACTN1	44,49	alpha-actinin 1	ACTN1	81634(Tax:10116)	81634(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Brain-specific splicing of alpha-actinin_1 -LRB- ACTN1 -RRB- mRNA .
7422059	0	alpha-albumin	90,103	GFA	105,108	alpha-albumin	GFA	282708(Tax:10116)	297417(Tax:10116)	Gene	Gene	determination|nmod|START_ENTITY determination|appos|END_ENTITY	Immunochemical determination and immunocytological localization of brain-specific protein alpha-albumin -LRB- GFA -RRB- in isolated astrocytes .
1878760	0	alpha-calcitonin_gene-related_peptide	30,67	endothelin-1	96,108	alpha-calcitonin gene-related peptide	endothelin-1	796	1906	Gene	Gene	administration|amod|START_ENTITY administration|nmod|END_ENTITY	Haemodynamic effects of human alpha-calcitonin_gene-related_peptide following administration of endothelin-1 or NG-nitro-L-arginine_methyl_ester in conscious rats .
12432063	0	alpha-catenin	67,80	CKII	15,19	alpha-catenin	CKII	1495	1457	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability .
10673383	0	alpha-catenin	72,85	E-cadherin	26,36	alpha-catenin	E-cadherin	1495	999	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin .
16767162	0	alpha-catenin	14,27	SHP2	51,55	alpha-catenin	SHP2	1495	5781	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3 .
19918298	0	alpha-catenin	16,29	VE-cadherin	37,48	alpha-catenin	VE-cadherin	1495	1003	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial_migration of leukocytes .
9152027	0	alpha-catenin	40,53	alpha-actinin	59,72	alpha-catenin	alpha-actinin	1495	87	Gene	Gene	interactions|nmod|START_ENTITY Characterization|nmod|interactions Characterization|nmod|END_ENTITY	Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin .
10694436	0	alpha-catenin	99,112	beta-catenin	12,24	alpha-catenin	beta-catenin	1495	1499	Gene	Gene	import|nmod|START_ENTITY Analysis|dep|import Analysis|nmod|aggregation aggregation|amod|END_ENTITY	Analysis of beta-catenin aggregation and localization using GFP fusion proteins : nuclear import of alpha-catenin by the beta-catenin/Tcf complex .
10896949	0	alpha-catenin	0,13	beta-catenin	23,35	alpha-catenin	beta-catenin	1495	1499	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
10896949	0	alpha-catenin	0,13	beta-catenin	75,87	alpha-catenin	beta-catenin	1495	1499	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|beta-catenin beta-catenin|acl|signaling signaling|advcl|preventing preventing|dobj|formation formation|nmod|complex complex|amod|END_ENTITY	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
12432063	0	alpha-catenin	67,80	beta-catenin	49,61	alpha-catenin	beta-catenin	1495	1499	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|interaction interaction|nmod|END_ENTITY	Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability .
15695815	0	alpha-catenin	136,149	beta-catenin	14,26	alpha-catenin	beta-catenin	1495	1499	Gene	Gene	degradation|nmod|START_ENTITY Regulation|nmod|degradation Regulation|nmod|signaling signaling|amod|END_ENTITY	Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin .
9110993	0	alpha-catenin	32,45	beta-catenin	79,91	alpha-catenin	beta-catenin	1495	1499	Gene	Gene	domain|nmod|START_ENTITY Identification|nmod|domain involved|nsubj|Identification involved|nmod|END_ENTITY	Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin -LRB- gamma-catenin -RRB- .
9264463	0	alpha-catenin	21,34	beta-catenin	55,67	alpha-catenin	beta-catenin	1495	1499	Gene	Gene	domain|nmod|START_ENTITY mediates|nsubj|domain mediates|xcomp|binding binding|nmod|END_ENTITY	A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin .
10461060	0	alpha-catenin	38,51	p53	74,77	alpha-catenin	p53	1495	7157	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cooccurrence of reduced expression of alpha-catenin and overexpression of p53 is a predictor of lymph_node_metastasis in early gastric_cancer .
11459101	0	alpha-chain	34,45	GM-CSF	6,12	alpha-chain	GM-CSF	2217	1437	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Human GM-CSF interaction with the alpha-chain of its receptor studied using surface plasmon resonance .
9344865	1	alpha-chain	206,217	IL-4	314,318	alpha-chain	IL-4	2217	3565	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of ligand binding to soluble IL-4 receptor alpha-chain by surface plasmon resonance measurements and by microtiter-plate-based ELISA with biotinylated IL-4 .
9574547	0	alpha-chain	38,49	IL-5	24,28	alpha-chain	IL-5	2217	3567	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5 , IL-3 , _ and_granulocyte-macrophage_colony-stimulating_factor in human blood eosinophils .
9574547	0	alpha-chain	38,49	IL-5	72,76	alpha-chain	IL-5	2217	3567	Gene	Gene	gene|amod|START_ENTITY inhibition|nmod|gene transcription|nsubj|inhibition transcription|nmod|and_granulocyte-macrophage_colony-stimulating_factor and_granulocyte-macrophage_colony-stimulating_factor|compound|END_ENTITY	Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5 , IL-3 , _ and_granulocyte-macrophage_colony-stimulating_factor in human blood eosinophils .
2449434	0	alpha-chain	48,59	beta-hexosaminidase	28,47	alpha-chain	beta-hexosaminidase	2217	10724	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Normal transcription of the beta-hexosaminidase alpha-chain gene in the Ashkenazi Tay-Sachs mutation .
2964446	0	alpha-chain	30,41	beta-hexosaminidase	67,86	alpha-chain	beta-hexosaminidase	2217	10724	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Proteolytic processing of the alpha-chain of the lysosomal enzyme , beta-hexosaminidase , in normal human fibroblasts .
6236461	0	alpha-chain	75,86	beta-hexosaminidase	40,59	alpha-chain	beta-hexosaminidase	2217	10724	Gene	Gene	mRNA|amod|START_ENTITY deficiency|nmod|mRNA clone|dep|deficiency clone|nmod|alpha-chain alpha-chain|nmod|END_ENTITY	cDNA clone for the alpha-chain of human beta-hexosaminidase : deficiency of alpha-chain mRNA in Ashkenazi Tay-Sachs fibroblasts .
3217923	0	alpha-chain	26,37	fibrinogen	13,23	alpha-chain	fibrinogen	2217	2244	Gene	Gene	Isolation|dep|START_ENTITY Isolation|nmod|END_ENTITY	Isolation of fibrinogen A alpha-chain by affinity chromatography on concanavalin A-sepharose .
2073325	0	alpha-chain	88,99	haptoglobin	56,67	alpha-chain	haptoglobin	2217	3240	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Hemoglobin binding with haptoglobin : delineation of the haptoglobin binding site on the alpha-chain of human hemoglobin .
17244787	0	alpha-chemokine	91,106	CXCL10	107,113	alpha-chemokine	CXCL10	3576	3627	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves ' _ disease or toxic_nodular_goiter .
11160345	0	alpha-chymase	96,109	tissue_inhibitor_of_metalloproteinase-1	10,49	alpha-chymase	tissue inhibitor of metalloproteinase-1	17228(Tax:10090)	21857(Tax:10090)	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Mast cell tissue_inhibitor_of_metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase .
15459207	0	alpha-enolase	50,63	ERK1/2	0,6	alpha-enolase	ERK1/2	24333(Tax:10116)	50689;116590	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic_hypoxia and reoxygenation .
15128351	0	alpha-fetoprotein	34,51	AFP	53,56	alpha-fetoprotein	AFP	174	174	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of elevated alpha-fetoprotein -LRB- AFP -RRB- in patients with chronic hepatitis_C , but not hepatocellular_carcinoma .
17433605	0	alpha-fetoprotein	63,80	AFP	82,85	alpha-fetoprotein	AFP	174	174	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Single nucleotide polymorphism in the promoter region of human alpha-fetoprotein -LRB- AFP -RRB- gene and its significance in hepatocellular_carcinoma -LRB- HCC -RRB- .
18276085	0	alpha-fetoprotein	6,23	AFP	25,28	alpha-fetoprotein	AFP	174	174	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum alpha-fetoprotein -LRB- AFP -RRB- levels in breastfed infants with prolonged indirect hyperbilirubinemia .
18795704	0	alpha-fetoprotein	34,51	AFP	53,56	alpha-fetoprotein	AFP	174	174	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of elevated alpha-fetoprotein -LRB- AFP -RRB- in chronic hepatitis_C without hepatocellular_carcinoma .
23038230	0	alpha-fetoprotein	27,44	AFP	46,49	alpha-fetoprotein	AFP	174	174	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Variations in normal serum alpha-fetoprotein -LRB- AFP -RRB- levels in patients with testicular_cancer on surveillance .
6181482	0	alpha-fetoprotein	8,25	AFP	27,30	alpha-fetoprotein	AFP	24177(Tax:10116)	24177(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of alpha-fetoprotein -LRB- AFP -RRB- in the regulation of ovarian activity during hepatocarcinogenesis and post-natal development .
6188026	0	alpha-fetoprotein	7,24	AFP	26,29	alpha-fetoprotein	AFP	174	174	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Serum alpha-fetoprotein -LRB- AFP -RRB- levels in liver_cirrhosis and viral_hepatitis cases -RSB- .
7541181	0	alpha-fetoprotein	36,53	AFP	55,58	alpha-fetoprotein	AFP	174	174	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- A case of bladder_cancer producing alpha-fetoprotein -LRB- AFP -RRB- -RSB- .
9786226	0	alpha-fetoprotein	25,42	AFP	44,47	alpha-fetoprotein	AFP	174	174	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of maternal serum alpha-fetoprotein -LRB- AFP -RRB- in pregnant women and subsequent breast_cancer risk .
11786962	0	alpha-fetoprotein	18,35	ATBF1	60,65	alpha-fetoprotein	ATBF1	174	463	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene Regulation|nmod|factor factor|compound|END_ENTITY	Regulation of the alpha-fetoprotein gene by the isoforms of ATBF1 transcription factor in human hepatoma .
1719379	0	alpha-fetoprotein	8,25	ATBF1	52,57	alpha-fetoprotein	ATBF1	174	463	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A human alpha-fetoprotein enhancer-binding protein , ATBF1 , contains four homeodomains and seventeen zinc fingers .
7507206	0	alpha-fetoprotein	108,125	ATBF1	0,5	alpha-fetoprotein	ATBF1	174	463	Gene	Gene	gene|amod|START_ENTITY AT-rich_elements|nmod|gene down-regulates|dobj|AT-rich_elements down-regulates|nsubj|END_ENTITY	ATBF1 , a multiple-homeodomain zinc finger protein , selectively down-regulates AT-rich_elements of the human alpha-fetoprotein gene .
1280422	0	alpha-fetoprotein	44,61	Hepatocyte_growth_factor	0,24	alpha-fetoprotein	Hepatocyte growth factor	174	3082	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor down-regulates the alpha-fetoprotein gene expression in PLC/PRF/5 human hepatoma cells .
21965270	0	alpha-fetoprotein	18,35	LHX4	50,54	alpha-fetoprotein	LHX4	174	89884	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Downregulation of alpha-fetoprotein expression by LHX4 : a critical role in hepatocarcinogenesis .
1705121	0	alpha-fetoprotein	59,76	Transforming_growth_factor_beta_1	0,33	alpha-fetoprotein	Transforming growth factor beta 1	174	7040	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 differentially regulates alpha-fetoprotein and albumin in HuH-7 human hepatoma cells .
24587407	0	alpha-fetoprotein	10,27	VEGF	37,41	alpha-fetoprotein	VEGF	174	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	Silencing alpha-fetoprotein inhibits VEGF and MMP-2 / 9 production in human hepatocellular_carcinoma cell .
18669658	0	alpha-fetoprotein	49,66	ZBTB20	20,26	alpha-fetoprotein	ZBTB20	11576(Tax:10090)	56490(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY repressor|nmod|transcription repressor|nsubj|END_ENTITY	Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver .
18194454	0	alpha-fetoprotein	23,40	ZHX2	0,4	alpha-fetoprotein	ZHX2	174	22882	Gene	Gene	expression|amod|START_ENTITY repressor|nmod|expression repressor|nsubj|END_ENTITY	ZHX2 is a repressor of alpha-fetoprotein expression in human hepatoma cell lines .
46623	0	alpha-fetoprotein	29,46	albumin	57,64	alpha-fetoprotein	albumin	11576(Tax:10090)	11657(Tax:10090)	Gene	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	Immunohistochemical study of alpha-fetoprotein and serum albumin in the early postnatal period in mice .
7521727	0	alpha-fetoprotein	39,56	alpha-fetoprotein	83,100	alpha-fetoprotein	alpha-fetoprotein	506011(Tax:9913)	506011(Tax:9913)	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization of bovine alpha-fetoprotein and comparison with human alpha-fetoprotein .
7521727	0	alpha-fetoprotein	83,100	alpha-fetoprotein	39,56	alpha-fetoprotein	alpha-fetoprotein	506011(Tax:9913)	506011(Tax:9913)	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization of bovine alpha-fetoprotein and comparison with human alpha-fetoprotein .
14745610	0	alpha-fetoprotein	57,74	c-Met	0,5	alpha-fetoprotein	c-Met	174	4233	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	c-Met expression in a gastric_cancer cell line producing alpha-fetoprotein .
17962101	0	alpha-fetoprotein	45,62	hCG	6,9	alpha-fetoprotein	hCG	174	93659	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|END_ENTITY	Total hCG versus free beta-hCG combined with alpha-fetoprotein for Down syndrome screening in Taiwan .
7531327	0	alpha-fetoprotein	24,41	hCG	51,54	alpha-fetoprotein	hCG	174	93659	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	The association between alpha-fetoprotein and beta hCG levels prior to and following chorionic_villus_sampling in cases that spontaneously miscarried .
24916573	0	alpha-fetoprotein	51,68	mucin	32,37	alpha-fetoprotein	mucin	174	100508689	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	The adenocarcinoma cell surface mucin receptor for alpha-fetoprotein : is the same receptor present on circulating monocytes and macrophages ?
6203880	0	alpha-fetoprotin	32,48	AFP	50,53	alpha-fetoprotin	AFP	11576(Tax:10090)	11576(Tax:10090)	Gene	Gene	localisation|nmod|START_ENTITY localisation|appos|END_ENTITY	Ultrastructural localisation of alpha-fetoprotin -LRB- AFP -RRB- in regenerating mouse liver poisoned with CCL4 .
8275706	0	alpha-fodrin	26,38	SPTAN1	45,51	alpha-fodrin	SPTAN1	6709	6709	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human alpha-fodrin gene -LRB- SPTAN1 -RRB- to 9q33 -- > q34 by fluorescence in situ hybridization .
6323102	0	alpha-galactosidase	25,44	GLA	46,49	alpha-galactosidase	GLA	2717	2717	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Regional localization of alpha-galactosidase -LRB- GLA -RRB- to Xpter -- q22 , hexosaminidase_B -LRB- HEXB -RRB- to 5q13 -- qter , and arylsulfatase_B -LRB- ARSB -RRB- to 5pter -- q13 .
167833	0	alpha-galactosidase_A	26,47	neuraminidase	71,84	alpha-galactosidase A	neuraminidase	2717	4758	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization of human alpha-galactosidase_A and B before and after neuraminidase treatment .
15464985	0	alpha-globin	36,48	Bach1	94,99	alpha-globin	Bach1	3040	571	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells .
20627634	0	alpha-hemoglobin-stabilizing_protein	12,48	AHSP	50,54	alpha-hemoglobin-stabilizing protein	AHSP	51327	51327	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of alpha-hemoglobin-stabilizing_protein -LRB- AHSP -RRB- gene as a genetic modifier to the phenotype of beta-thalassemia in Southern China .
18024509	0	alpha-hydroxysteroid_dehydrogenase	22,56	AKR1C4	58,64	alpha-hydroxysteroid dehydrogenase	AKR1C4	1109	1109	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of human 3 alpha-hydroxysteroid_dehydrogenase -LRB- AKR1C4 -RRB- expression by the liver X receptor alpha .
3372809	0	alpha-lactalbumin	80,97	growth_hormone	62,76	alpha-lactalbumin	growth hormone	281894(Tax:9913)	14599(Tax:10090)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Influence of recombinant deoxyribonucleic_acid-derived bovine growth_hormone on alpha-lactalbumin production by bovine mammary tissue maintained in athymic nude_mice .
20126537	0	alpha-melanocyte-stimulating_hormone	17,53	CD8	109,112	alpha-melanocyte-stimulating hormone	CD8	18976(Tax:10090)	925	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|development development|nmod|cells cells|compound|END_ENTITY	The neuropeptide alpha-melanocyte-stimulating_hormone is critically involved in the development of cytotoxic CD8 + T cells in mice and humans .
18930089	0	alpha-melanocyte-stimulating_hormone	81,117	Corticotropin-releasing_factor	0,30	alpha-melanocyte-stimulating hormone	Corticotropin-releasing factor	18976(Tax:10090)	12918(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- is involved in the acute anorexic effect of alpha-melanocyte-stimulating_hormone : a study using CRF-deficient mice .
8854136	0	alpha-melanocyte-stimulating_hormone	57,93	Corticotropin-releasing_hormone	0,31	alpha-melanocyte-stimulating hormone	Corticotropin-releasing hormone	5443	1392	Gene	Gene	levels|amod|START_ENTITY increases|dobj|levels increases|nsubj|administration administration|amod|END_ENTITY	Corticotropin-releasing_hormone administration increases alpha-melanocyte-stimulating_hormone levels in the inferior petrosal sinuses in a subset of patients with Cushing 's _ disease .
15833358	0	alpha-melanocyte-stimulating_hormone	34,70	IRAK-M	119,125	alpha-melanocyte-stimulating hormone	IRAK-M	5443	11213	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	The immunomodulating neuropeptide alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- suppresses LPS-stimulated TLR4 with IRAK-M in macrophages .
15833358	0	alpha-melanocyte-stimulating_hormone	34,70	TLR4	109,113	alpha-melanocyte-stimulating hormone	TLR4	5443	7099	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	The immunomodulating neuropeptide alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- suppresses LPS-stimulated TLR4 with IRAK-M in macrophages .
2172391	0	alpha-melanocyte-stimulating_hormone	64,100	Tyrosinase	0,10	alpha-melanocyte-stimulating hormone	Tyrosinase	5443	7299	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Tyrosinase synthesis in different skin types and the effects of alpha-melanocyte-stimulating_hormone and cyclic_AMP .
17525122	0	alpha-melanocyte-stimulating_hormone	163,199	agouti-related_protein	107,129	alpha-melanocyte-stimulating hormone	agouti-related protein	5443	181	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Cocaine - _ and_amphetamine-regulated_transcript -LRB- CART -RRB- is colocalized with the orexigenic neuropeptide Y and agouti-related_protein and absent from the anorexigenic alpha-melanocyte-stimulating_hormone neurons in the infundibular nucleus of the human hypothalamus .
19889022	0	alpha-melanocyte-stimulating_hormone	10,46	alpha-MSH	48,57	alpha-melanocyte-stimulating hormone	alpha-MSH	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Increased alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic_dermatitis .
2828246	0	alpha-melanocyte-stimulating_hormone	13,49	alpha-MSH	51,60	alpha-melanocyte-stimulating hormone	alpha-MSH	5443	5443	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Evidence for alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- receptors on human malignant_melanoma cells .
3516302	0	alpha-melanocyte-stimulating_hormone	35,71	alpha-MSH	73,82	alpha-melanocyte-stimulating hormone	alpha-MSH	5443	5443	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and identification of alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- in the frog brain .
6297686	0	alpha-melanocyte-stimulating_hormone	49,85	alpha-MSH	87,96	alpha-melanocyte-stimulating hormone	alpha-MSH	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biological and immunological characterization of alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- in two neuronal systems of the rat brain .
11019900	0	alpha-melanocyte-stimulating_hormone	114,150	corticotropin-releasing_factor	26,56	alpha-melanocyte-stimulating hormone	corticotropin-releasing factor	24664(Tax:10116)	81648(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of endogenous corticotropin-releasing_factor in mediation of neuroendocrine and behavioral effects to alpha-melanocyte-stimulating_hormone .
7970145	0	alpha-melanocyte-stimulating_hormone	26,62	corticotropin-releasing_factor	72,102	alpha-melanocyte-stimulating hormone	corticotropin-releasing factor	24664(Tax:10116)	81648(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY inhibits|nsubj|administration inhibits|dobj|release release|amod|END_ENTITY	Central administration of alpha-melanocyte-stimulating_hormone inhibits corticotropin-releasing_factor release in adrenalectomized rats .
10936035	0	alpha-melanocyte-stimulating_hormone	230,266	corticotropin-releasing_hormone	278,309	alpha-melanocyte-stimulating hormone	corticotropin-releasing hormone	5443	1392	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Pituitary proopiomelanocortin-derived peptides and hypothalamus-pituitary-interrenal_axis activity in gilthead sea bream -LRB- Sparus aurata -RRB- during prolonged crowding stress : differential regulation of adrenocorticotropin hormone and alpha-melanocyte-stimulating_hormone release by corticotropin-releasing_hormone and thyrotropin-releasing_hormone .
14691168	0	alpha-melanocyte-stimulating_hormone	99,135	cyclooxygenase-2	60,76	alpha-melanocyte-stimulating hormone	cyclooxygenase-2	24664(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of endotoxin-induced uveitis and potentiation of cyclooxygenase-2 protein expression by alpha-melanocyte-stimulating_hormone .
16118510	0	alpha-melanocyte-stimulating_hormone	10,46	interleukin_8	50,63	alpha-melanocyte-stimulating hormone	interleukin 8	5443	3576	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of alpha-melanocyte-stimulating_hormone on interleukin_8 and monocyte_chemotactic_protein_1 expression in a human retinal pigment epithelial cell line .
7099389	0	alpha-melanocyte-stimulating_hormone	10,46	prolactin	82,91	alpha-melanocyte-stimulating hormone	prolactin	24664(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of alpha-melanocyte-stimulating_hormone on basal and stimulated release of prolactin : evidence for dopaminergic mediation .
8875950	0	alpha-melanocyte-stimulating_hormone	57,93	tyrosinase	14,24	alpha-melanocyte-stimulating hormone	tyrosinase	18976(Tax:10090)	22173(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation of tyrosinase mRNA in mouse melanoma cells by alpha-melanocyte-stimulating_hormone .
11488983	0	alpha-melanocyte_stimulating_hormone	72,108	CD4	28,31	alpha-melanocyte stimulating hormone	CD4	18976(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	In vitro induction of CD25 + CD4 + regulatory T cells by the neuropeptide alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- .
11093286	0	alpha-melanocyte_stimulating_hormone	26,62	alpha-MSH	64,73	alpha-melanocyte stimulating hormone	alpha-MSH	5443	5443	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated plasma levels of alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- are correlated with insulin resistance in obese men .
99212	0	alpha-melanocyte_stimulating_hormone	36,72	alpha-MSH	74,83	alpha-melanocyte stimulating hormone	alpha-MSH	5443	5443	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- in the human hypothalamus .
933208	0	alpha-melanocyte_stimulating_hormone	14,50	alpha-msh	52,61	alpha-melanocyte stimulating hormone	alpha-msh	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of alpha-melanocyte_stimulating_hormone -LRB- alpha-msh -RRB- on the metabolism of biogenic amines in the rat brain .
16224209	0	alpha-methyl_CoA_racemase	26,51	AMACR	53,58	alpha-methyl CoA racemase	AMACR	23600	23600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Age-associated changes in alpha-methyl_CoA_racemase -LRB- AMACR -RRB- expression in nonneoplastic prostatic tissues .
22009118	0	alpha-methyl_CoA_racemase	20,45	AMACR	47,52	alpha-methyl CoA racemase	AMACR	23600	23600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic value of alpha-methyl_CoA_racemase -LRB- AMACR -RRB- expression in renal_cell_carcinoma .
4209419	0	alpha-methyl_dopa	71,88	dopa_decarboxylase	92,110	alpha-methyl dopa	dopa decarboxylase	35188(Tax:7227)	35190(Tax:7227)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	The selection for mutants in Drosophila_melanogaster hypersensitive to alpha-methyl_dopa , a dopa_decarboxylase inhibitor .
933208	0	alpha-msh	52,61	alpha-melanocyte_stimulating_hormone	14,50	alpha-msh	alpha-melanocyte stimulating hormone	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of alpha-melanocyte_stimulating_hormone -LRB- alpha-msh -RRB- on the metabolism of biogenic amines in the rat brain .
15567155	0	alpha-myosin_heavy_chain	21,45	Yin_Yang_1	0,10	alpha-myosin heavy chain	Yin Yang 1	29605(Tax:10116)	24919(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Yin_Yang_1 represses alpha-myosin_heavy_chain gene expression in pathologic cardiac_hypertrophy .
10634932	0	alpha-pal	55,64	E2F-1	30,35	alpha-pal	E2F-1	4899	1869	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Transcriptional regulation of E2F-1 and eIF-2 genes by alpha-pal : a potential mechanism for coordinated regulation of protein synthesis , growth , and the cell cycle .
15383601	0	alpha-smooth_muscle_actin	67,92	IL-1_beta	112,121	alpha-smooth muscle actin	IL-1 beta	25365(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	CCAAT/enhancer-binding protein beta isoforms and the regulation of alpha-smooth_muscle_actin gene expression by IL-1_beta .
12075473	0	alpha-smooth_muscle_actin	21,46	IL-1beta	1,9	alpha-smooth muscle actin	IL-1beta	25365(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	-LSB- IL-1beta stimulates alpha-smooth_muscle_actin expression through JNK/p38 signal pathway in cultured rat mesangial cells -RSB- .
9013984	0	alpha-smooth_muscle_actin	30,55	IL-1beta	108,116	alpha-smooth muscle actin	IL-1beta	25365(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY fibroblast|dobj|expression fibroblast|nmod|END_ENTITY	Regulation of lung fibroblast alpha-smooth_muscle_actin expression , contractile phenotype , and apoptosis by IL-1beta .
16397521	0	alpha-smooth_muscle_actin	15,40	IL-6	0,4	alpha-smooth muscle actin	IL-6	11475(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	IL-6 modulates alpha-smooth_muscle_actin expression in dermal fibroblasts from IL-6-deficient mice .
7720396	0	alpha-smooth_muscle_actin	44,69	TGF-beta_1	0,10	alpha-smooth muscle actin	TGF-beta 1	25365(Tax:10116)	59086(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	TGF-beta_1 induces lens cells to accumulate alpha-smooth_muscle_actin , a marker for subcapsular cataracts .
8314838	0	alpha-smooth_muscle_actin	42,67	Transforming_growth_factor-beta_1	0,33	alpha-smooth muscle actin	Transforming growth factor-beta 1	25365(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 induces alpha-smooth_muscle_actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts .
15110760	0	alpha-synuclein	29,44	BDNF	0,4	alpha-synuclein	BDNF	6622	627	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	BDNF is induced by wild-type alpha-synuclein but not by the two mutants , A30P or A53T , in glioma cell line .
20405200	0	alpha-synuclein	18,33	BDNF	49,53	alpha-synuclein	BDNF	6622	627	Gene	Gene	down-regulates|amod|START_ENTITY Overexpression|nmod|down-regulates END_ENTITY|nsubj|Overexpression	Overexpression of alpha-synuclein down-regulates BDNF expression .
19432400	0	alpha-synuclein	30,45	CD4	70,73	alpha-synuclein	CD4	6622	920	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|+ +|compound|END_ENTITY	Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4 + CD25 + T cells .
22076255	0	alpha-synuclein	25,40	CSF	0,3	alpha-synuclein	CSF	6622	1437	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative_disease .
16959772	0	alpha-synuclein	22,37	Dyrk1A	0,6	alpha-synuclein	Dyrk1A	6622	1859	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation .
19645749	0	alpha-synuclein	51,66	E6-AP	21,26	alpha-synuclein	E6-AP	6622	7337	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein .
11162638	0	alpha-synuclein	29,44	Fyn	10,13	alpha-synuclein	Fyn	6622	2534	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125 .
18322396	0	alpha-synuclein	46,61	Leucine-rich_repeat_kinase_2	0,28	alpha-synuclein	Leucine-rich repeat kinase 2	6622	120892	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	Leucine-rich_repeat_kinase_2 colocalizes with alpha-synuclein in Parkinson 's _ disease , but not tau-containing deposits in tauopathies .
20074637	0	alpha-synuclein	37,52	Leucine-rich_repeat_kinase_2	0,28	alpha-synuclein	Leucine-rich repeat kinase 2	6622	120892	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leucine-rich_repeat_kinase_2 induces alpha-synuclein expression via the extracellular_signal-regulated_kinase pathway .
15099022	0	alpha-synuclein	28,43	Niemann-Pick_type_C1_disease	53,81	alpha-synuclein	Niemann-Pick type C1 disease	6622	4864	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick_type_C1_disease .
18463503	0	alpha-synuclein	52,67	Nurr1	0,5	alpha-synuclein	Nurr1	6622	4929	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nurr1 transcriptionally regulates the expression of alpha-synuclein .
22705949	0	alpha-synuclein	29,44	PGC1alpha	52,61	alpha-synuclein	PGC1alpha	6622	10891	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function : implications for Parkinson 's _ disease .
15978696	0	alpha-synuclein	10,25	PKCdelta	64,72	alpha-synuclein	PKCdelta	6622	5580	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP + - induced apoptotic cell death .
11751692	0	alpha-synuclein	68,83	SNCA	90,94	alpha-synuclein	SNCA	6622	6622	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene -LRB- SNCA -RRB- on transcription in a cell culture luciferase reporter system .
20443127	0	alpha-synuclein	88,103	SNCA	110,114	alpha-synuclein	SNCA	6622	6622	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cardiac sympathetic denervation precedes nigrostriatal loss in the E46K mutation of the alpha-synuclein gene -LRB- SNCA -RRB- .
18841091	0	alpha-synuclein	14,29	X_receptor	50,60	alpha-synuclein	X receptor	6622	9213	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of alpha-synuclein expression by liver X_receptor ligands in vitro .
12958153	0	alpha-synuclein	47,62	dopamine_transporter	14,34	alpha-synuclein	dopamine transporter	6622	6531	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	Modulation of dopamine_transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress .
20074637	0	alpha-synuclein	37,52	extracellular_signal-regulated_kinase	72,109	alpha-synuclein	extracellular signal-regulated kinase	6622	5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Leucine-rich_repeat_kinase_2 induces alpha-synuclein expression via the extracellular_signal-regulated_kinase pathway .
11435921	0	alpha-synuclein	14,29	interleukin-1beta	83,100	alpha-synuclein	interleukin-1beta	6622	3553	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1beta .
15207266	0	alpha-synuclein	9,24	rab3a	43,48	alpha-synuclein	rab3a	6622	5864	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse_Lewy_body_disease .
19762560	0	alpha-synuclein	61,76	synphilin-1	17,28	alpha-synuclein	synphilin-1	6622	9627	Gene	Gene	formation|nmod|START_ENTITY formation|amod|END_ENTITY	Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein : mechanistic insights and pathological implication .
17592526	0	alpha-synuclein	10,25	tyrosine_hydroxylase	54,74	alpha-synuclein	tyrosine hydroxylase	6622	7054	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|gene gene|amod|END_ENTITY	Effect of alpha-synuclein on the promoter activity of tyrosine_hydroxylase gene .
18357527	0	alpha-synuclein	10,25	tyrosine_hydroxylase	51,71	alpha-synuclein	tyrosine hydroxylase	6622	7054	Gene	Gene	expression|amod|START_ENTITY Silencing|dobj|expression enhances|csubj|Silencing enhances|dobj|activity activity|amod|END_ENTITY	Silencing alpha-synuclein gene expression enhances tyrosine_hydroxylase activity in MN9D cells .
18406059	0	alpha-synuclein	51,66	tyrosine_hydroxylase	98,118	alpha-synuclein	tyrosine hydroxylase	6622	7054	Gene	Gene	increase|nmod|START_ENTITY inhibits|dobj|increase inhibits|nmod|END_ENTITY	Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine_hydroxylase in SK-N-SH cells .
21656370	0	alpha-synuclein	16,31	tyrosine_hydroxylase	75,95	alpha-synuclein	tyrosine hydroxylase	6622	7054	Gene	Gene	START_ENTITY|nmod|CREB CREB|acl|signaling signaling|nmod|expression expression|amod|END_ENTITY	Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine_hydroxylase gene expression in SK-N-BE -LRB- 2 -RRB- C cells .
21368133	0	alpha-tectorin	74,88	Carcinoembryonic_antigen-related_cell_adhesion_molecule_16	0,58	alpha-tectorin	Carcinoembryonic antigen-related cell adhesion molecule 16	7007	388551	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Carcinoembryonic_antigen-related_cell_adhesion_molecule_16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing_loss -LRB- DFNA4 -RRB- .
9503015	0	alpha-tectorin	15,29	TECTA	36,41	alpha-tectorin	TECTA	21683(Tax:10090)	21683(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the alpha-tectorin gene -LRB- TECTA -RRB- to mouse chromosome 9 and human chromosome 11 : a candidate for human autosomal_dominant_nonsyndromic_deafness .
12651045	0	alpha-tropomyosin	68,85	TPM1	87,91	alpha-tropomyosin	TPM1	7168	7168	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variable clinical manifestation of a novel missense mutation in the alpha-tropomyosin -LRB- TPM1 -RRB- gene in familial hypertrophic_cardiomyopathy .
12196661	0	alpha-tropomyosin	29,46	TPM3	53,57	alpha-tropomyosin	TPM3	7168	7170	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations of the slow muscle alpha-tropomyosin gene , TPM3 , are a rare cause of nemaline_myopathy .
9465305	0	alpha-tubulin	54,67	TUBA2	74,79	alpha-tubulin	TUBA2	10376	7278	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence characterization of a newly identified human alpha-tubulin gene -LRB- TUBA2 -RRB- .
18523284	0	alpha-tubulin	36,49	granzyme_M	17,27	alpha-tubulin	granzyme M	10376	3004	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	NK cell protease granzyme_M targets alpha-tubulin and disorganizes the microtubule network .
10637289	0	alpha1	26,32	Ser-16	44,50	alpha1	Ser-16	146	3190209(Tax:176280)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Is phosphorylation of the alpha1 subunit at Ser-16 involved in the control of Na,K-ATPase activity by phorbol_ester-activated protein kinase C ?
17448722	0	alpha1-Antitrypsin	0,18	CD14	29,33	alpha1-Antitrypsin	CD14	5265	929	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	alpha1-Antitrypsin regulates CD14 expression and soluble CD14 levels in human monocytes in vitro .
9461605	0	alpha1-antichymotrypsin	87,110	Oncostatin_M	0,12	alpha1-antichymotrypsin	Oncostatin M	12	5008	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Oncostatin_M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes .
18283111	0	alpha1-antitrypsin	69,87	ERGIC-53	18,26	alpha1-antitrypsin	ERGIC-53	5265	3998	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin .
11237765	0	alpha1B-adrenergic_receptor	83,110	c-Jun_N-terminal_kinase	15,38	alpha1B-adrenergic receptor	c-Jun N-terminal kinase	147	5599	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of c-Jun_N-terminal_kinase and p38_mitogen-activated_protein_kinase in alpha1B-adrenergic_receptor / Galphaq-induced inhibition of cell proliferation .
15461460	0	alpha1B-glycoprotein	49,69	Cysteine-rich_secretory_protein_3	0,33	alpha1B-glycoprotein	Cysteine-rich secretory protein 3	1	10321	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Cysteine-rich_secretory_protein_3 is a ligand of alpha1B-glycoprotein in human plasma .
16352594	0	alpha1b-adrenergic_receptor	34,61	Ezrin	0,5	alpha1b-adrenergic receptor	Ezrin	147	7430	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ezrin directly interacts with the alpha1b-adrenergic_receptor and plays a role in receptor recycling .
15592877	0	alpha2-HS_glycoprotein	15,37	AHSG	39,43	alpha2-HS glycoprotein	AHSG	197	197	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of alpha2-HS_glycoprotein -LRB- AHSG , fetuin-A -RRB- polymorphism with AHSG and phosphate serum levels .
20881288	0	alpha2-Macroglobulin	0,20	glial_fibrillary_acidic_protein	29,60	alpha2-Macroglobulin	glial fibrillary acidic protein	232345(Tax:10090)	14580(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	alpha2-Macroglobulin induces glial_fibrillary_acidic_protein expression mediated by low-density_lipoprotein_receptor-related_protein_1 in M ller cells .
16275122	0	alpha2-macroglobulin	24,44	Panza	14,19	alpha2-macroglobulin	Panza	100158443(Tax:8355)	100189580(Tax:8355)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Panza , an alpha2-macroglobulin , in a restricted dorsal domain of the primitive gut in Xenopus_laevis .
9593670	0	alpha2-macroglobulin	40,60	alpha2-macroglobulin	68,88	alpha2-macroglobulin	alpha2-macroglobulin	2	2	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase .
9593670	0	alpha2-macroglobulin	68,88	alpha2-macroglobulin	40,60	alpha2-macroglobulin	alpha2-macroglobulin	2	2	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase .
9731707	0	alpha2-macroglobulin	68,88	alpha2M	90,97	alpha2-macroglobulin	alpha2M	24153(Tax:10116)	24153(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Stat_5b and the orphan nuclear receptors regulate expression of the alpha2-macroglobulin -LRB- alpha2M -RRB- gene in rat ovarian granulosa cells .
9831625	0	alpha2-macroglobulin	37,57	apolipoprotein_E	15,31	alpha2-macroglobulin	apolipoprotein E	2	348	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of apolipoprotein_E with alpha2-macroglobulin in human plasma .
17071617	0	alpha2-macroglobulin	74,94	bone_morphogenetic_protein_1	14,42	alpha2-macroglobulin	bone morphogenetic protein 1	2	649	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of bone_morphogenetic_protein_1 by native and altered forms of alpha2-macroglobulin .
9808760	0	alpha2-macroglobulin	75,95	myelin_basic_protein	19,39	alpha2-macroglobulin	myelin basic protein	2	4155	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of soluble myelin_basic_protein to various conformational forms of alpha2-macroglobulin .
9582381	0	alpha2-macroglobulin	78,98	transforming_growth_factor-beta	37,68	alpha2-macroglobulin	transforming growth factor-beta	2	7040	Gene	Gene	Localization|nmod|START_ENTITY Localization|nmod|END_ENTITY	Localization of the binding site for transforming_growth_factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region .
14769885	0	alpha2-macroglobulin	144,164	transforming_growth_factor-beta1	37,69	alpha2-macroglobulin	transforming growth factor-beta1	2	7040	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Hepatitis_B virus X antigen promotes transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- activity by up-regulation of TGF-beta1 and down-regulation of alpha2-macroglobulin .
15777792	0	alpha2/beta1	155,167	vimentin	34,42	alpha2/beta1	vimentin	3779	7431	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The intermediate filament protein vimentin binds specifically to a recombinant integrin alpha2/beta1 cytoplasmic tail complex and co-localizes with native alpha2/beta1 in endothelial cell focal adhesions .
19225179	0	alpha2A_adrenergic_receptor	81,108	CA3	141,144	alpha2A adrenergic receptor	CA3	11551(Tax:10090)	12350(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A_adrenergic_receptor inhibition of mouse hippocampal CA3 epileptiform_activity .
19225179	0	alpha2A_adrenergic_receptor	81,108	Galphao	56,63	alpha2A adrenergic receptor	Galphao	11551(Tax:10090)	14681(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Regulator of G protein signaling protein suppression of Galphao protein-mediated alpha2A_adrenergic_receptor inhibition of mouse hippocampal CA3 epileptiform_activity .
15900214	0	alpha2B-adrenergic_receptor	17,44	ADRA2B	51,57	alpha2B-adrenergic receptor	ADRA2B	151	151	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the alpha2B-adrenergic_receptor gene -LRB- ADRA2B -RRB- and its relationship to vascular response in vivo .
9731707	0	alpha2M	90,97	alpha2-macroglobulin	68,88	alpha2M	alpha2-macroglobulin	24153(Tax:10116)	24153(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Stat_5b and the orphan nuclear receptors regulate expression of the alpha2-macroglobulin -LRB- alpha2M -RRB- gene in rat ovarian granulosa cells .
10555956	0	alpha4	16,22	Atp1a4	29,35	alpha4	Atp1a4	3476	27222(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Na,K-ATPase alpha4 gene -LRB- Atp1a4 -RRB- encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene -LRB- Atp1a2 -RRB- on mouse chromosome 1 .
18762859	0	alpha4	48,54	CHRNA4	126,132	alpha4	CHRNA4	3476	1137	Gene	Gene	subunits|amod|START_ENTITY analysis|nmod|subunits analysis|nmod|genes genes|appos|END_ENTITY	Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes -LRB- CHRNA4 and CHRNB2 -RRB- with schizophrenia in the Japanese population .
12766617	0	alpha4	22,28	Chrna4	54,60	alpha4	Chrna4	18518(Tax:10090)	11438(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism in the alpha4 nicotinic receptor gene -LRB- Chrna4 -RRB- modulates enhancement of nicotinic receptor function by ethanol .
16517231	0	alpha4	38,44	IgBP1	54,59	alpha4	IgBP1	3476	3476	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Low resolution structure of the human alpha4 protein -LRB- IgBP1 -RRB- and studies on the stability of alpha4 and of its yeast ortholog Tap42 .
9616217	0	alpha4	99,105	beta1	106,111	alpha4	beta1	3476	3779	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and function .
9867821	0	alpha4	31,37	beta1	38,43	alpha4	beta1	3476	3779	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Cooperative role for activated alpha4 beta1 integrin and chondroitin sulfate proteoglycans in cell adhesion to the heparin III domain of fibronectin .
16227616	0	alpha4	82,88	c-Src	131,136	alpha4	c-Src	18518(Tax:10090)	6714	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Integrin alpha4beta1 promotes focal_adhesion_kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src .
9782083	0	alpha7_neuronal_nicotinic_acetylcholine_receptor	58,106	CHRNA7	113,119	alpha7 neuronal nicotinic acetylcholine receptor	CHRNA7	1139	1139	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and partial duplication of the human alpha7_neuronal_nicotinic_acetylcholine_receptor gene -LRB- CHRNA7 -RRB- .
15456958	0	alphaA-crystallin-binding_protein_1	32,67	Col2a1	149,155	alphaA-crystallin-binding protein 1	Col2a1	110521(Tax:10090)	12824(Tax:10090)	Gene	Gene	site|amod|START_ENTITY mimicking|dobj|site Oligonucleotide|dep|mimicking stimulates|amod|Oligonucleotide transcription|nsubj|stimulates transcription|nmod|promoter promoter|amod|END_ENTITY	Oligonucleotide decoy mimicking alphaA-crystallin-binding_protein_1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell .
15456958	0	alphaA-crystallin-binding_protein_1	32,67	Col2a1	90,96	alphaA-crystallin-binding protein 1	Col2a1	110521(Tax:10090)	12824(Tax:10090)	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Oligonucleotide decoy mimicking alphaA-crystallin-binding_protein_1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell .
18343576	0	alphaB-crystallin	51,68	LEDGF	0,5	alphaB-crystallin	LEDGF	25420(Tax:10116)	313323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	LEDGF binding to stress response element increases alphaB-crystallin expression in astrocytes with oxidative stress .
17904375	0	alphaB-crystallin	48,65	Protein_kinase_C_delta	0,22	alphaB-crystallin	Protein kinase C delta	25420(Tax:10116)	170538(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Protein_kinase_C_delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes .
20023214	0	alphaB-crystallin	0,17	VEGF	62,66	alphaB-crystallin	VEGF	12955(Tax:10090)	22339(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	alphaB-crystallin regulation of angiogenesis by modulation of VEGF .
19878675	0	alphaB-crystallin	19,36	cryab	38,43	alphaB-crystallin	cryab	396089(Tax:9031)	396089(Tax:9031)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in retinal alphaB-crystallin -LRB- cryab -RRB- RNA transcript levels during periods of altered ocular growth in chickens .
10023666	0	alphaE-catenin	4,18	CTNNA1	25,31	alphaE-catenin	CTNNA1	1495	1495	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The alphaE-catenin gene -LRB- CTNNA1 -RRB- acts as an invasion-suppressor gene in human colon_cancer cells .
18397997	0	alphaE-catenin	0,14	beta-catenin	49,61	alphaE-catenin	beta-catenin	1495	1499	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain .
19389371	0	alphaE-catenin	19,33	beta-catenin	84,96	alphaE-catenin	beta-catenin	1495	1499	Gene	Gene	reduction|nmod|START_ENTITY causes|nsubj|reduction causes|dobj|differentiation differentiation|nmod|END_ENTITY	Focal reduction of alphaE-catenin causes premature differentiation and reduction of beta-catenin signaling during cortical development .
12499396	0	alphaPIX	15,23	PARVB	52,57	alphaPIX	PARVB	9459	29780	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of alphaPIX -LRB- ARHGEF6 -RRB- with beta-parvin -LRB- PARVB -RRB- suggests an involvement of alphaPIX in integrin-mediated signaling .
6450208	0	alpha_1	52,59	beta_1	80,86	alpha 1	beta 1	146	10678	Gene	Gene	goes|nsubj|START_ENTITY goes|nmod|END_ENTITY	Purification and characterization of a rabbit liver alpha_1 goes to 3 mannoside beta_1 goes to 2 N-acetylglucosaminyltransferase .
7789167	0	alpha_1-acid_glycoprotein	14,39	ORM1	46,50	alpha 1-acid glycoprotein	ORM1	396901(Tax:9823)	396901(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of alpha_1-acid_glycoprotein gene -LRB- ORM1 -RRB- to swine chromosome region 1q210 -- > q212 by fluorescence in situ hybridization .
3490907	0	alpha_1-antichymotrypsin	44,68	DNA_polymerase_alpha	20,40	alpha 1-antichymotrypsin	DNA polymerase alpha	12	5422	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human DNA_polymerase_alpha by alpha_1-antichymotrypsin .
8747137	0	alpha_1-antichymotrypsin	46,70	IL-1_beta	0,9	alpha 1-antichymotrypsin	IL-1 beta	12	3553	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	IL-1_beta and TNF_alpha , but not IL-6 , induce alpha_1-antichymotrypsin expression in the human astrocytoma cell line U373 MG .
8863511	0	alpha_1-antichymotrypsin	72,96	Interleukin-1_beta	0,18	alpha 1-antichymotrypsin	Interleukin-1 beta	12	3553	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Interleukin-1_beta and tumor_necrosis_factor-alpha induce expression of alpha_1-antichymotrypsin in human astrocytoma cells by activation of nuclear_factor-kappa_B .
2130541	0	alpha_1-antichymotrypsin	49,73	alpha_1-antichymotrypsin	90,114	alpha 1-antichymotrypsin	alpha 1-antichymotrypsin	12	12	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	The isoelectric focusing pattern of desialylated alpha_1-antichymotrypsin of heterozygous alpha_1-antichymotrypsin deficiency and of acute phase plasma .
2130541	0	alpha_1-antichymotrypsin	90,114	alpha_1-antichymotrypsin	49,73	alpha 1-antichymotrypsin	alpha 1-antichymotrypsin	12	12	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	The isoelectric focusing pattern of desialylated alpha_1-antichymotrypsin of heterozygous alpha_1-antichymotrypsin deficiency and of acute phase plasma .
15686474	0	alpha_1-antichymotrypsin	12,36	interleukin-1	56,69	alpha 1-antichymotrypsin	interleukin-1	12	3552	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Duration of alpha_1-antichymotrypsin gene activation by interleukin-1 is determined by efficiency of inhibitor of nuclear factor kappa B alpha resynthesis in primary human astrocytes .
7527116	0	alpha_1-antichymotrypsin	71,95	prostate_specific_antigen	24,49	alpha 1-antichymotrypsin	prostate specific antigen	12	354	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of prostate_specific_antigen and its complex with alpha_1-antichymotrypsin before diagnosis of prostate_cancer .
20886262	0	alpha_1-antitrypsin	64,83	Hrd1	21,25	alpha 1-antitrypsin	Hrd1	5265	84447	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha_1-antitrypsin and increases its solubility .
8920996	0	alpha_1-antitrypsin	21,40	THP-1	131,136	alpha 1-antitrypsin	THP-1	5265	2736	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Divergent effects of alpha_1-antitrypsin on the regulation of iron metabolism in human erythroleukaemic -LRB- K562 -RRB- and myelomonocytic -LRB- THP-1 -RRB- cells .
6966514	0	alpha_1-antitrypsin	39,58	alpha_1-protease_inhibitor	11,37	alpha 1-antitrypsin	alpha 1-protease inhibitor	5265	5265	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of alpha_1-protease_inhibitor -LRB- alpha_1-antitrypsin -RRB- on the intensity of phytohemagglutinin stimulated lymphocyte transformation -RSB- .
1385708	0	alpha_1-antitrypsin	14,33	granulocyte_macrophage_colony-stimulating_factor	47,95	alpha 1-antitrypsin	granulocyte macrophage colony-stimulating factor	5265	1437	Gene	Gene	synthesis|amod|START_ENTITY Regulation|nmod|synthesis Regulation|nmod|END_ENTITY	Regulation of alpha_1-antitrypsin synthesis by granulocyte_macrophage_colony-stimulating_factor in the U937 promonocytic cell line .
2454897	0	alpha_1-fetoprotein	24,43	AFP	45,48	alpha 1-fetoprotein	AFP	174	174	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Correlation between the alpha_1-fetoprotein -LRB- AFP -RRB- concentrations determined in the sera and in the tumour tissues in patients with testicular_tumours .
1383209	0	alpha_1-microglobulin	108,129	bikunin	130,137	alpha 1-microglobulin	bikunin	259	259	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A potent enhancer made of clustered liver-specific elements in the transcription control sequences of human alpha_1-microglobulin / bikunin gene .
6966514	0	alpha_1-protease_inhibitor	11,37	alpha_1-antitrypsin	39,58	alpha 1-protease inhibitor	alpha 1-antitrypsin	5265	5265	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of alpha_1-protease_inhibitor -LRB- alpha_1-antitrypsin -RRB- on the intensity of phytohemagglutinin stimulated lymphocyte transformation -RSB- .
1630052	0	alpha_1_protease_inhibitor	23,49	IL-1	71,75	alpha 1 protease inhibitor	IL-1	5265	3553	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	-LSB- Inhibitory effects of alpha_1_protease_inhibitor on the production of IL-1 and TNF_alpha by alveolar macrophages in patients with lung_cancer -RSB- .
2689875	0	alpha_2	16,23	Mcm1	79,83	alpha 2	Mcm1	850406(Tax:4932)	855060(Tax:4932)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Yeast repressor alpha_2 binds to its operator cooperatively with yeast protein Mcm1 .
7906861	0	alpha_2-HS-glycoprotein	6,29	insulin_receptor	59,75	alpha 2-HS-glycoprotein	insulin receptor	197	3643	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Serum alpha_2-HS-glycoprotein is an inhibitor of the human insulin_receptor at the tyrosine kinase level .
15589849	0	alpha_2-Heremans_Schmidt_glycoprotein	26,63	AHSG	65,69	alpha 2-Heremans Schmidt glycoprotein	AHSG	197	197	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between human alpha_2-Heremans_Schmidt_glycoprotein -LRB- AHSG -RRB- polymorphism and endometriosis in Korean women .
9383708	0	alpha_2-Macroglobulin	0,21	THP-1	65,70	alpha 2-Macroglobulin	THP-1	2	2736	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	alpha_2-Macroglobulin synthesis by the human monocytic cell line THP-1 is differentiation state-dependent .
11839752	0	alpha_2-Macroglobulin	0,21	lipoprotein_receptor-related_protein	97,133	alpha 2-Macroglobulin	lipoprotein receptor-related protein	24153(Tax:10116)	25167(Tax:10116)	Gene	Gene	exposure|amod|START_ENTITY reduces|nsubj|exposure reduces|nmod|N-methyl-D-aspartate N-methyl-D-aspartate|nmod|END_ENTITY	alpha_2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein_receptor-related_protein in cultured hippocampal neurons .
17656111	0	alpha_2-antiplasmin	26,45	SERPINF2	47,55	alpha 2-antiplasmin	SERPINF2	5345	5345	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Impact of Triton_X-100 on alpha_2-antiplasmin -LRB- SERPINF2 -RRB- activity in solvent/detergent-treated plasma .
90334	0	alpha_2-macroglobulin	15,36	L-asparaginase	42,56	alpha 2-macroglobulin	L-asparaginase	2	80150	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of alpha_2-macroglobulin with L-asparaginase .
7687998	0	alpha_2-macroglobulin	109,130	LDL_receptor-related_protein	80,108	alpha 2-macroglobulin	LDL receptor-related protein	232345(Tax:10090)	16971(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	A comparison of the roles of the low_density_lipoprotein _ -LRB- LDL -RRB- _ receptor and the LDL_receptor-related_protein / alpha_2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo .
11435418	1	alpha_2-macroglobulin	59,80	LRP	144,147	alpha 2-macroglobulin	LRP	2	4035	Gene	Gene	complex|amod|START_ENTITY complex|nmod|lipoprotein_receptor-related_protein lipoprotein_receptor-related_protein|appos|END_ENTITY	alpha_2-macroglobulin complex with low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- .
11435418	2	alpha_2-macroglobulin	166,187	LRP	188,191	alpha 2-macroglobulin	LRP	2	4035	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Evidence for an alpha_2-macroglobulin / LRP receptor-mediated system participating in LCAT clearance .
7537086	0	alpha_2-macroglobulin	30,51	Neurotrophin	0,12	alpha 2-macroglobulin	Neurotrophin	2	627	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Neurotrophin binding to human alpha_2-macroglobulin under apparent equilibrium conditions .
7681826	0	alpha_2-macroglobulin	64,85	Vascular_endothelial_growth_factor	0,34	alpha 2-macroglobulin	Vascular endothelial growth factor	2	7422	Gene	Gene	binding|advcl|START_ENTITY inactivated|advcl|binding inactivated|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor is inactivated by binding to alpha_2-macroglobulin and the binding is inhibited by heparin .
7518427	0	alpha_2-macroglobulin	65,86	alpha_2M	88,96	alpha 2-macroglobulin	alpha 2M	2	2	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The relationship between low density lipoprotein-related_protein / alpha_2-macroglobulin -LRB- alpha_2M -RRB- receptors and the newly described alpha_2M signaling receptor .
8902214	0	alpha_2-macroglobulin	79,100	alpha_2M	102,110	alpha 2-macroglobulin	alpha 2M	24153(Tax:10116)	24153(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Prolactin-induced activation and binding of stat proteins to the IL-6RE of the alpha_2-macroglobulin -LRB- alpha_2M -RRB- promoter : relation to the expression of alpha_2M in the rat ovary .
1716791	0	alpha_2-macroglobulin	14,35	cathepsin_G	63,74	alpha 2-macroglobulin	cathepsin G	2	1511	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of alpha_2-macroglobulin on human polymorphonuclear cathepsin_G .
2445377	0	alpha_2-macroglobulin	51,72	factor_Xa	38,47	alpha 2-macroglobulin	factor Xa	2	2159	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human blood_coagulation factor_Xa by alpha_2-macroglobulin .
1282854	0	alpha_2-macroglobulin	125,146	interleukin-6	82,95	alpha 2-macroglobulin	interleukin-6	24153(Tax:10116)	24498(Tax:10116)	Gene	Gene	abscesses|xcomp|START_ENTITY abscesses|nmod|relationship relationship|nmod|END_ENTITY	Effect of aseptic abscesses in protein-deficient rats on the relationship between interleukin-6 and the acute-phase protein , alpha_2-macroglobulin .
2466233	0	alpha_2-macroglobulin	103,124	interleukin-6	57,70	alpha 2-macroglobulin	interleukin-6	24153(Tax:10116)	24498(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene expression|amod|dependent dependent|amod|END_ENTITY	Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha_2-macroglobulin gene .
2479916	0	alpha_2-macroglobulin	76,97	interleukin-6	36,49	alpha 2-macroglobulin	interleukin-6	24153(Tax:10116)	24498(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY element|nmod|gene element|amod|responsive responsive|amod|END_ENTITY	Nuclear factors interacting with an interleukin-6 responsive element of rat alpha_2-macroglobulin gene .
2483766	0	alpha_2-macroglobulin	14,35	interleukin-6	55,68	alpha 2-macroglobulin	interleukin-6	24153(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of alpha_2-macroglobulin gene expression by interleukin-6 -LRB- BSF-2 / HSF -RRB- .
6202319	0	alpha_2-macroglobulin	64,85	kallikrein	28,38	alpha 2-macroglobulin	kallikrein	2	9622	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human plasma kallikrein and its light chain with alpha_2-macroglobulin .
7516153	0	alpha_2-macroglobulin	33,54	lipoprotein_lipase	11,29	alpha 2-macroglobulin	lipoprotein lipase	2	4023	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of lipoprotein_lipase to alpha_2-macroglobulin .
11435418	1	alpha_2-macroglobulin	59,80	lipoprotein_receptor-related_protein	106,142	alpha 2-macroglobulin	lipoprotein receptor-related protein	2	4035	Gene	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	alpha_2-macroglobulin complex with low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- .
1502153	0	alpha_2-macroglobulin	193,214	lipoprotein_receptor-related_protein	156,192	alpha 2-macroglobulin	lipoprotein receptor-related protein	2	4035	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein_receptor-related_protein / alpha_2-macroglobulin receptor .
1718973	0	alpha_2-macroglobulin	96,117	lipoprotein_receptor-related_protein	59,95	alpha 2-macroglobulin	lipoprotein receptor-related protein	2	4035	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	39-kDa protein modulates binding of ligands to low density lipoprotein_receptor-related_protein / alpha_2-macroglobulin receptor .
1700488	0	alpha_2-macroglobulin	94,115	plasmin	14,21	alpha 2-macroglobulin	plasmin	2	5340	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|miniplasmin miniplasmin|compound|END_ENTITY	Regulation of plasmin , miniplasmin , and streptokinase-plasmin complex by alpha_2-antiplasmin , alpha_2-macroglobulin , and antithrombin_III in the presence of heparin .
1708234	0	alpha_2-macroglobulin	65,86	plasmin	52,59	alpha 2-macroglobulin	plasmin	2	5340	Gene	Gene	inhibit|advcl|START_ENTITY inhibit|dobj|reaction reaction|nmod|END_ENTITY	Soluble fibrin preparations inhibit the reaction of plasmin with alpha_2-macroglobulin .
2441753	0	alpha_2-macroglobulin	81,102	plasmin	68,75	alpha 2-macroglobulin	plasmin	2	5340	Gene	Gene	modes|nmod|START_ENTITY modes|nmod|END_ENTITY	Some consequences of the covalent and non-covalent binding modes of plasmin with alpha_2-macroglobulin .
4228070	0	alpha_2-macroglobulin	45,66	plasmin	20,27	alpha 2-macroglobulin	plasmin	2	5340	Gene	Gene	Competition|nmod|START_ENTITY Competition|nmod|END_ENTITY	Competition between plasmin and thrombin for alpha_2-macroglobulin .
6196052	0	alpha_2-macroglobulin	18,39	plasmin	60,67	alpha 2-macroglobulin	plasmin	2	5340	Gene	Gene	half-molecules|amod|START_ENTITY Reaction|nmod|half-molecules Reaction|nmod|END_ENTITY	Reaction of human alpha_2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure .
6197993	0	alpha_2-macroglobulin	40,61	plasmin	21,28	alpha 2-macroglobulin	plasmin	2	5340	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human plasmin with human alpha_2-macroglobulin .
8530514	0	alpha_2-macroglobulin	30,51	platelet-derived_growth_factor_alpha-receptor	75,120	alpha 2-macroglobulin	platelet-derived growth factor alpha-receptor	24153(Tax:10116)	25267(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Native and activated forms of alpha_2-macroglobulin increase expression of platelet-derived_growth_factor_alpha-receptor in vascular smooth muscle cells .
6193011	0	alpha_2-macroglobulin	30,51	thrombin	53,61	alpha 2-macroglobulin	thrombin	2	2147	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Structural arrangement in the alpha_2-macroglobulin -- thrombin complex .
2473082	0	alpha_2-macroglobulin	123,144	transforming_growth_factor-beta	91,122	alpha 2-macroglobulin	transforming growth factor-beta	2	7040	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Transforming_growth_factor-beta activity is potentiated by heparin via dissociation of the transforming_growth_factor-beta / alpha_2-macroglobulin inactive complex .
1370602	0	alpha_2-macroglobulin	66,87	transforming_growth_factor-beta_1	11,44	alpha 2-macroglobulin	transforming growth factor-beta 1	2	7040	Gene	Gene	START_ENTITY|amod|immobilized immobilized|amod|END_ENTITY	Binding of transforming_growth_factor-beta_1 to immobilized human alpha_2-macroglobulin .
1718991	0	alpha_2-macroglobulin	54,75	transforming_growth_factor-beta_1	15,48	alpha 2-macroglobulin	transforming growth factor-beta 1	232345(Tax:10090)	21803(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of transforming_growth_factor-beta_1 with alpha_2-macroglobulin .
7508936	0	alpha_2-macroglobulin	20,41	trk	48,51	alpha 2-macroglobulin	trk	24153(Tax:10116)	59109(Tax:10116)	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Monoamine-activated alpha_2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction .
10862607	0	alpha_2-macroglobulin	42,63	vascular_endothelial_growth_factor	69,103	alpha 2-macroglobulin	vascular endothelial growth factor	2	7422	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The conformation-dependent interaction of alpha_2-macroglobulin with vascular_endothelial_growth_factor .
3416655	0	alpha_2-plasmin_inhibitor	24,49	PLI	56,59	alpha 2-plasmin inhibitor	PLI	5345	5345	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human alpha_2-plasmin_inhibitor gene -LRB- PLI -RRB- to chromosome region 18p11 .1 -- q11 .2 by in situ hybridization .
2503265	0	alpha_2HS-glycoprotein	73,95	Zn_alpha_2-glycoprotein	33,56	alpha 2HS-glycoprotein	Zn alpha 2-glycoprotein	197	563	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Unusually high concentrations of Zn_alpha_2-glycoprotein and the lack of alpha_2HS-glycoprotein in human ejaculates .
7518427	0	alpha_2M	88,96	alpha_2-macroglobulin	65,86	alpha 2M	alpha 2-macroglobulin	2	2	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The relationship between low density lipoprotein-related_protein / alpha_2-macroglobulin -LRB- alpha_2M -RRB- receptors and the newly described alpha_2M signaling receptor .
8902214	0	alpha_2M	102,110	alpha_2-macroglobulin	79,100	alpha 2M	alpha 2-macroglobulin	24153(Tax:10116)	24153(Tax:10116)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Prolactin-induced activation and binding of stat proteins to the IL-6RE of the alpha_2-macroglobulin -LRB- alpha_2M -RRB- promoter : relation to the expression of alpha_2M in the rat ovary .
7519632	0	alpha_2_macroglobulin	30,51	Interferon_gamma	0,16	alpha 2 macroglobulin	Interferon gamma	2	3458	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Interferon_gamma up-regulates alpha_2_macroglobulin expression in human astrocytoma cells .
1833569	0	alpha_2_plasmin_inhibitor	109,134	plasmin	101,108	alpha 2 plasmin inhibitor	plasmin	5345	5340	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	-LSB- Plasma levels of antithrombin III , thrombin-antithrombin III complex , alpha_2_plasmin_inhibitor and plasmin alpha_2_plasmin_inhibitor complex in normal and sick newborn infants -RSB- .
12920208	0	alpha_2_type_I_collagen	62,85	COL1A2	92,98	alpha 2 type I collagen	COL1A2	1278	1278	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	5-fluorouracil blocks transforming_growth_factor-beta-induced alpha_2_type_I_collagen gene -LRB- COL1A2 -RRB- expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation .
6177693	0	alpha_2u-globulin	31,48	growth_hormone	65,79	alpha 2u-globulin	growth hormone	298111(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Pretranslational regulation of alpha_2u-globulin in rat liver by growth_hormone .
7517944	0	alpha_4	18,25	beta_1	26,32	alpha 4	beta 1	3476	3779	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Activation of the alpha_4 beta_1 integrin through the beta_1 subunit induces recognition of the RGDS sequence in fibronectin .
10079513	0	alpha_6	12,19	Connexin45	0,10	alpha 6	Connexin45	14399(Tax:10090)	14615(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Connexin45 -LRB- alpha_6 -RRB- expression delineates an extended conduction system in the embryonic and mature rodent heart .
1698797	0	alpha_6	31,38	beta_4	39,45	alpha 6	beta 4	14399(Tax:10090)	10381	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	The alpha_6 beta 1 -LRB- VLA-6 -RRB- and alpha_6 beta_4 protein complexes : tissue distribution and biochemical properties .
8319775	0	alpha_6	47,54	beta_4	55,61	alpha 6	beta 4	14399(Tax:10090)	140489(Tax:10090)	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Redistribution of the hemidesmosome components alpha_6 beta_4 integrin and bullous pemphigoid antigens during epithelial wound healing .
8732671	0	alpha_6	42,49	beta_4	50,56	alpha 6	beta 4	14399(Tax:10090)	140489(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|amod|END_ENTITY	Selective changes in laminin adhesion and alpha_6 beta_4 integrin regulation are associated with the initial steps in keratinocyte maturation .
11912199	0	alpha_7_nicotinic_receptor	85,111	presenilin_1	166,178	alpha 7 nicotinic receptor	presenilin 1	11441(Tax:10090)	5663	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Accelerated plaque accumulation , associative learning_deficits , and up-regulation of alpha_7_nicotinic_receptor protein in transgenic_mice co-expressing mutant human presenilin_1 and amyloid precursor proteins .
11945023	0	alpha_B-crystallin	51,69	titin	101,106	alpha B-crystallin	titin	25420(Tax:10116)	84015(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Ischemia-induced association of the stress protein alpha_B-crystallin with I-band portion of cardiac titin .
12815278	0	alpha_II-spectrin	57,74	caspase_3	30,39	alpha II-spectrin	caspase 3	6709	836	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Identification of the primary caspase_3 cleavage site in alpha_II-spectrin during apoptosis .
8394152	0	alpha_MSH	0,9	c-fos	49,54	alpha MSH	c-fos	24664(Tax:10116)	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	alpha_MSH but not Org_2766 induces expression of c-fos in cultured rat spinal cord cells .
6401174	0	alpha_MSH	162,171	thyrotropin-releasing_hormone	183,212	alpha MSH	thyrotropin-releasing hormone	5443	7200	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Catecholaminergic control of alpha-melanocyte-stimulating_hormone -LRB- alpha_MSH -RRB- release by frog neurointermediate lobe in vitro : evidence for direct stimulation of alpha_MSH release by thyrotropin-releasing_hormone .
6401174	0	alpha_MSH	67,76	thyrotropin-releasing_hormone	183,212	alpha MSH	thyrotropin-releasing hormone	5443	7200	Gene	Gene	release|appos|START_ENTITY control|nmod|release control|dep|evidence evidence|nmod|stimulation stimulation|nmod|release release|nmod|END_ENTITY	Catecholaminergic control of alpha-melanocyte-stimulating_hormone -LRB- alpha_MSH -RRB- release by frog neurointermediate lobe in vitro : evidence for direct stimulation of alpha_MSH release by thyrotropin-releasing_hormone .
1924379	0	alpha_catenin	33,46	vinculin	52,60	alpha catenin	vinculin	1495	22330(Tax:10090)	Gene	Gene	homologue|nsubj|START_ENTITY homologue|compound|END_ENTITY	The uvomorulin-anchorage protein alpha_catenin is a vinculin homologue .
21365646	0	alpha_fetoprotein	24,41	GADD153	92,99	alpha fetoprotein	GADD153	174	1649	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Impact of intracellular alpha_fetoprotein on retinoic_acid receptors-mediated expression of GADD153 in human hepatoma cell lines .
14715623	0	alpha_hemoglobin_stabilizing_protein	14,50	AHSP	52,56	alpha hemoglobin stabilizing protein	AHSP	51327	51327	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of alpha_hemoglobin_stabilizing_protein -LRB- AHSP -RRB- as a genetic modifier in patients with beta_thalassemia .
17874450	0	alpha_hemoglobin_stabilizing_protein	27,63	AHSP	65,69	alpha hemoglobin stabilizing protein	AHSP	51327	51327	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Population analysis of the alpha_hemoglobin_stabilizing_protein -LRB- AHSP -RRB- gene identifies sequence variants that alter expression and function .
21142933	0	alpha_hemoglobin_stabilizing_protein	30,66	AHSP	68,72	alpha hemoglobin stabilizing protein	AHSP	51327	51327	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A twins heritability study on alpha_hemoglobin_stabilizing_protein -LRB- AHSP -RRB- expression variability .
12644691	0	alternative_oxidase	18,37	Aox1	38,42	alternative oxidase	Aox1	5728961(Tax:3055)	5720157(Tax:3055)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Regulation of the alternative_oxidase Aox1 gene in Chlamydomonas_reinhardtii .
18045880	0	ameloblastin	45,57	TrkB	85,89	ameloblastin	TrkB	11698(Tax:10090)	18212(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Neurotrophic_factor neurotrophin-4 regulates ameloblastin expression via full-length TrkB .
23426651	0	amelogenin_Y-linked	10,29	AMELY	31,36	amelogenin Y-linked	AMELY	266	266	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Activated amelogenin_Y-linked -LRB- AMELY -RRB- regulation and angiogenesis in human hepatocellular_carcinoma by biocomputation .
18349698	0	amiloride-sensitive_cation_channel_2	32,68	ACCN2	70,75	amiloride-sensitive cation channel 2	ACCN2	41	41	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between the amiloride-sensitive_cation_channel_2 -LRB- ACCN2 -RRB- gene and anxiety_spectrum_disorders .
18467109	0	amino-peptidase_N	63,80	CD13	81,85	amino-peptidase N	CD13	290	290	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Design , synthesis , and QSAR studies of novel lysine derives as amino-peptidase_N / CD13 inhibitors .
22106287	0	aminoacyl-tRNA_synthetase-interacting_multifunctional_protein-3	105,168	methionyl-tRNA_synthetase	13,38	aminoacyl-tRNA synthetase-interacting multifunctional protein-3	methionyl-tRNA synthetase	9521	4141	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Dual role of methionyl-tRNA_synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA_synthetase-interacting_multifunctional_protein-3 .
2163618	0	aminoglycoside_phosphotransferase	11,44	APH	46,49	aminoglycoside phosphotransferase	APH	4246774(Tax:562)	4246774(Tax:562)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of aminoglycoside_phosphotransferase -LRB- APH -RRB- gene from antibiotic-producing strain of Bacillus circulans into a high-expression vector , pKK223-3 .
21783619	0	aminolevulinic_acid_dehydratase	12,43	ALAD	45,49	aminolevulinic acid dehydratase	ALAD	210	210	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Reversal of aminolevulinic_acid_dehydratase -LRB- ALAD -RRB- inhibition and reduction of erythrocyte protoporphyrin levels by Vitamin_C in occupational lead exposure in Abeokuta , Nigeria .
8188235	0	aminomethyltransferase	46,68	AMT	75,78	aminomethyltransferase	AMT	275	275	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and chromosomal localization of the aminomethyltransferase gene -LRB- AMT -RRB- The gene for human aminomethyltransferase -LRB- AMT -RRB- , also known as the T-protein of the glycine cleavage system , was isolated from a human placental cosmid library and examined by restriction mapping , polymerase chain reaction analysis , and DNA sequencing .
12487019	0	aminomethyltransferase	35,57	Amt	64,67	aminomethyltransferase	Amt	434437(Tax:10090)	434437(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the murine aminomethyltransferase gene -LRB- Amt -RRB- .
8432738	0	aminopeptidase	68,82	TGF_alpha	98,107	aminopeptidase	TGF alpha	10404	7039	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Low fluences of ultraviolet irradiation stimulate HeLa cell surface aminopeptidase and candidate `` TGF_alpha ase '' activity .
924762	0	aminopeptidase	14,28	aminopeptidase	41,55	aminopeptidase	aminopeptidase	10404	10404	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Serum cystine aminopeptidase and leucine aminopeptidase activity in women with benign and malignant uterine and ovarian_tumors .
924762	0	aminopeptidase	41,55	aminopeptidase	14,28	aminopeptidase	aminopeptidase	10404	10404	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Serum cystine aminopeptidase and leucine aminopeptidase activity in women with benign and malignant uterine and ovarian_tumors .
8555027	0	aminopeptidase	24,38	leukotriene_A4_hydrolase	61,85	aminopeptidase	leukotriene A4 hydrolase	10404	4048	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Characterization of the aminopeptidase activity of epidermal leukotriene_A4_hydrolase against the opioid dynorphin fragment 1-7 .
1168550	0	aminopeptidase	74,88	oxytocinase	53,64	aminopeptidase	oxytocinase	10404	4012	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	A rapid and specific method for the determination of oxytocinase -LRB- cystine aminopeptidase -RRB- activity using continuous flow analysis and S-benzyl-L-cysteine-p-nitroanilide as substrate .
1421209	0	aminopeptidase	47,61	oxytocinase	26,37	aminopeptidase	oxytocinase	10404	4012	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human serum oxytocinase -LRB- cystine aminopeptidase , E. C. 3.4.11.3 -RRB- by GnRH peptides .
3186091	0	aminopeptidase	24,38	oxytocinase	40,51	aminopeptidase	oxytocinase	10404	4012	Gene	Gene	Change|nmod|START_ENTITY Change|appos|END_ENTITY	Change in plasma cystyl aminopeptidase -LRB- oxytocinase -RRB- between 30-34 weeks ' gestation as a predictor of pregnancy-induced hypertension .
970009	0	aminopeptidase	28,42	oxytocinase	50,61	aminopeptidase	oxytocinase	10404	4012	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of L-cystine aminopeptidase -LRB- serum oxytocinase , EC 3.4.1.2 -RRB- during normal pregnancy -RSB- .
22796679	0	aminopeptidase	95,109	pepN	110,114	aminopeptidase	pepN	10404	290	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Development of a primer system to study abundance and diversity of the gene coding for alanine aminopeptidase pepN gene in Gram-negative soil bacteria .
5988895	0	aminopeptidase	58,72	phosphohexose_isomerase	22,45	aminopeptidase	phosphohexose isomerase	10404	2821	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|dobj|levels	-LSB- Changes in the serum phosphohexose_isomerase and leucine aminopeptidase levels during lysozyme treatment of viral hepatitis in childhood -RSB- .
6362658	0	aminopeptidase	39,53	transferrin	15,26	aminopeptidase	transferrin	10404	7018	Gene	Gene	START_ENTITY|nsubj|Reliability Reliability|nmod|END_ENTITY	Reliability of transferrin and leucine aminopeptidase phenotyping in wild meadow voles -LRB- Microtus pennsylvanicus -RRB- .
19608358	0	aminopeptidase_A	26,42	APA	44,47	aminopeptidase A	APA	64017(Tax:10116)	64017(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of recombinant aminopeptidase_A -LRB- APA -RRB- on hypertension in pregnant spontaneously hypertensive rats -LRB- SHRs -RRB- .
10024339	0	aminopeptidase_A	7,23	angiotensin_II	62,76	aminopeptidase A	angiotensin II	64017(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Kidney aminopeptidase_A and hypertension , part II : effects of angiotensin_II .
11729240	0	aminopeptidase_A	58,74	angiotensin_II	84,98	aminopeptidase A	angiotensin II	13809(Tax:10090)	11606(Tax:10090)	Gene	Gene	antibodies|nmod|START_ENTITY injection|nmod|antibodies mice|nmod|injection Albuminuria|nmod|mice Albuminuria|dep|role role|nmod|END_ENTITY	Albuminuria in mice after injection of antibodies against aminopeptidase_A : role of angiotensin_II .
12409962	0	aminopeptidase_A	24,40	angiotensin_II	143,157	aminopeptidase A	angiotensin II	64017(Tax:10116)	24179(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of aminopeptidase_A in hypertension in spontaneously hypertensive rats -LRB- SHRs -RRB- and change of refractoriness in response to angiotensin_II in pregnant SHRs .
6679727	0	aminopeptidase_A	32,48	angiotensin_II	76,90	aminopeptidase A	angiotensin II	2028	183	Gene	Gene	properties|nmod|START_ENTITY properties|dep|degradation degradation|nmod|END_ENTITY	Kinetic properties of placental aminopeptidase_A : N-terminal degradation of angiotensin_II .
8346219	0	aminopeptidase_A	75,91	differentiation_antigen_gp160	38,67	aminopeptidase A	differentiation antigen gp160	2028	2028	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of the human kidney differentiation_antigen_gp160 : human aminopeptidase_A .
12614948	0	aminopeptidase_A	32,48	oxytocinase	101,112	aminopeptidase A	oxytocinase	2028	4012	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Ultrastructural localization of aminopeptidase_A / angiotensinase and placental_leucine_aminopeptidase / oxytocinase in chorionic villi of human placenta .
21550066	0	aminopeptidase_N	24,40	APN	42,45	aminopeptidase N	APN	290	290	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of alanine aminopeptidase_N -LRB- APN -RRB- in bile in the diagnosis of acute cellular rejection after liver transplantation .
14679016	0	aminopeptidase_N	27,43	CD13	44,48	aminopeptidase N	CD13	290	290	Gene	Gene	significance|nmod|START_ENTITY significance|dep|END_ENTITY	Biological significance of aminopeptidase_N / CD13 in thyroid_carcinomas .
15138629	0	aminopeptidase_N	49,65	CD13	66,70	aminopeptidase N	CD13	290	290	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	IL-10 and TGF-beta differ in their regulation of aminopeptidase_N / CD13 expression in monocytes .
22307623	0	aminopeptidase_N	23,39	CD13	41,45	aminopeptidase N	CD13	16790(Tax:10090)	16790(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Cooperative effects of aminopeptidase_N -LRB- CD13 -RRB- expressed by nonmalignant and cancer cells within the tumor microenvironment .
7829125	0	aminopeptidase_N	14,30	CD13	31,35	aminopeptidase N	CD13	290	290	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of aminopeptidase_N / CD13 in tumour-infiltrating lymphocytes from human renal_cell_carcinoma .
7904539	0	aminopeptidase_N	18,34	CD13	36,40	aminopeptidase N	CD13	290	290	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the aminopeptidase_N -LRB- CD13 -RRB- gene in the human T cell lines HuT78 and H9 .
15792835	0	aminopeptidase_N	14,30	interferon-gamma	59,75	aminopeptidase N	interferon-gamma	290	3458	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of aminopeptidase_N -LRB- EC 3.4.11.2 ; APN ; CD13 -RRB- by interferon-gamma on the HL-60 cell line .
19236739	0	aml-1	14,19	eto	20,23	aml-1	eto	861	862	Gene	Gene	/|amod|START_ENTITY Detection|nmod|/ END_ENTITY|nsubj|Detection	-LSB- Detection of aml-1 / eto fusion gene in patients with acute_myeloid_leukemia by real-time quantitative RT-PCR -RSB- .
21937427	0	amotl2	23,29	Angiomotin-like2	0,16	amotl2	Angiomotin-like2	558920(Tax:7955)	558920(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Angiomotin-like2 gene -LRB- amotl2 -RRB- is required for migration and proliferation of endothelial cells during angiogenesis .
20103632	0	amphiregulin	16,28	BRCA1	0,5	amphiregulin	BRCA1	374	672	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	BRCA1 represses amphiregulin gene expression .
17942395	0	amphiregulin	61,73	Epidermal_growth_factor_receptor	0,32	amphiregulin	Epidermal growth factor receptor	374	1956	Gene	Gene	identifies|dobj|START_ENTITY identifies|nsubj|analysis analysis|amod|END_ENTITY	Epidermal_growth_factor_receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast_cancer cells .
25147440	0	amphiregulin	15,27	MMP-13	36,42	amphiregulin	MMP-13	374	4322	Gene	Gene	START_ENTITY|acl|induced induced|dobj|production production|compound|END_ENTITY	The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast .
22570239	0	amphiregulin	23,35	Polycystin-1	0,12	amphiregulin	Polycystin-1	11839(Tax:10090)	18763(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling : implications in ADPKD cell proliferation .
23285165	0	amphiregulin	14,26	b-catenin	46,55	amphiregulin	b-catenin	374	1499	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of amphiregulin gene expression by b-catenin signaling in human hepatocellular_carcinoma cells : a novel crosstalk between FGF19 and the EGFR system .
24813021	0	amphiregulin	108,120	epidermal_growth_factor	18,41	amphiregulin	epidermal growth factor	374	1950	Gene	Gene	expression|appos|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	The expression of epidermal_growth_factor receptors and their ligands -LRB- epidermal_growth_factor , neuregulin , amphiregulin -RRB- in the bitch uterus during the estrus cycle .
17548638	0	amphiregulin	201,213	epidermal_growth_factor_receptor	48,80	amphiregulin	epidermal growth factor receptor	374	1956	Gene	Gene	release|nmod|START_ENTITY cells|nmod|release signaling|nmod|cells signaling|nsubj|transactivation transactivation|compound|END_ENTITY	Macrophage-inflammatory_protein-3alpha mediates epidermal_growth_factor_receptor transactivation and ERK1/2 MAPK signaling in Caco-2 colonic epithelial cells via metalloproteinase-dependent release of amphiregulin .
18634036	0	amphiregulin	44,56	epidermal_growth_factor_receptor	4,36	amphiregulin	epidermal growth factor receptor	11839(Tax:10090)	13649(Tax:10090)	Gene	Gene	participates|nsubj|START_ENTITY ligand|ccomp|participates ligand|nsubj|END_ENTITY	The epidermal_growth_factor_receptor ligand amphiregulin participates in the development of mouse liver_fibrosis .
19815304	0	amphiregulin	44,56	epidermal_growth_factor_receptor	4,36	amphiregulin	epidermal growth factor receptor	11839(Tax:10090)	13649(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY ligand|ccomp|regulator ligand|nsubj|END_ENTITY	The epidermal_growth_factor_receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression .
20803614	0	amphiregulin	19,31	epidermal_growth_factor_receptor	60,92	amphiregulin	epidermal growth factor receptor	374	1956	Gene	Gene	expression|compound|START_ENTITY expression|nmod|patients patients|nmod|END_ENTITY	Clinical impact of amphiregulin expression in patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- wild-type nonsmall_cell_lung_cancer treated with EGFR-tyrosine kinase inhibitors .
7679104	1	amphiregulin	115,127	epidermal_growth_factor_receptor	157,189	amphiregulin	epidermal growth factor receptor	374	1956	Gene	Gene	Evidence|dep|START_ENTITY acts|nsubj|Evidence acts|nmod|END_ENTITY	Evidence that amphiregulin acts exclusively through the epidermal_growth_factor_receptor at the surface of human epithelial cells .
9542658	0	amphiregulin	14,26	epidermal_growth_factor_receptor	95,127	amphiregulin	epidermal growth factor receptor	374	1956	Gene	Gene	expression|compound|START_ENTITY Topography|nmod|expression Topography|dep|colocalization colocalization|nmod|END_ENTITY	Topography of amphiregulin expression in cultured human keratinocytes : colocalization with the epidermal_growth_factor_receptor and CD44 .
17520403	0	amphiregulin	14,26	hCG	59,62	amphiregulin	hCG	374	3342	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of amphiregulin , EGFR-like factor expression by hCG in cultured human granulosa cells .
20807286	0	amylin	40,46	Butyrylcholinesterase	0,21	amylin	Butyrylcholinesterase	3375	590	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic_syndrome .
21589925	0	amylin	18,24	CCR2	137,141	amylin	CCR2	15874(Tax:10090)	12772(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	MCP-1 upregulates amylin expression in murine pancreatic b cells through ERK/JNK-AP 1 and NF-kB related signaling pathways independent of CCR2 .
14521933	0	amylin	49,55	Hepatocyte_nuclear_factor_1	0,27	amylin	Hepatocyte nuclear factor 1	3375	6927	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hepatocyte_nuclear_factor_1 negatively regulates amylin gene expression .
21589925	0	amylin	18,24	MCP-1	0,5	amylin	MCP-1	15874(Tax:10090)	20296(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	MCP-1 upregulates amylin expression in murine pancreatic b cells through ERK/JNK-AP 1 and NF-kB related signaling pathways independent of CCR2 .
8392334	0	amylin	160,166	calcitonin-gene-related_neuropeptide	116,152	amylin	calcitonin-gene-related neuropeptide	3375	796	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related_neuropeptide -LRB- CGRP -RRB- / amylin receptor .
10051146	0	amylin	15,21	calcitonin_gene-related_peptide	27,58	amylin	calcitonin gene-related peptide	3375	796	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Interaction of amylin with calcitonin_gene-related_peptide receptors in the microvasculature of the hamster cheek pouch in vivo .
11111008	0	amylin	85,91	cholecystokinin	40,55	amylin	cholecystokinin	24476(Tax:10116)	25298(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY END_ENTITY|nmod|antagonist	Attenuation of the anorectic effects of cholecystokinin and bombesin by the specific amylin antagonist AC 253 .
11994903	0	amylin	8,14	insulin	100,107	amylin	insulin	3375	3630	Gene	Gene	Role|nmod|START_ENTITY Role|dep|studies studies|nmod|spectrum spectrum|nmod|sensitivity sensitivity|compound|END_ENTITY	Role of amylin in insulin secretion and action in humans : antagonist studies across the spectrum of insulin sensitivity .
11994903	0	amylin	8,14	insulin	18,25	amylin	insulin	3375	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Role of amylin in insulin secretion and action in humans : antagonist studies across the spectrum of insulin sensitivity .
1534057	0	amylin	27,33	insulin	37,44	amylin	insulin	24476(Tax:10116)	3630	Gene	Gene	hypersecretion|nmod|START_ENTITY hypersecretion|nmod|END_ENTITY	Relative hypersecretion of amylin to insulin from rat pancreas after neonatal STZ treatment .
2055340	0	amylin	49,55	insulin	87,94	amylin	insulin	3375	3630	Gene	Gene	levels|nmod|START_ENTITY indicate|nsubj|levels indicate|nmod|END_ENTITY	Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans .
2227135	0	amylin	43,49	insulin	13,20	amylin	insulin	3375	3630	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|resistance resistance|compound|END_ENTITY	Induction of insulin resistance in vivo by amylin and calcitonin_gene-related_peptide .
3050530	0	amylin	11,17	insulin	74,81	amylin	insulin	3375	3630	Gene	Gene	gene-related|nsubj|START_ENTITY gene-related|nmod|END_ENTITY	Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro .
8477949	0	amylin	11,17	insulin	36,43	amylin	insulin	24476(Tax:10116)	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of amylin on the release of insulin and glucagon from the perfused rat pancreas .
10973971	0	amylin	15,21	insulin-degrading_enzyme	25,49	amylin	insulin-degrading enzyme	24476(Tax:10116)	25700(Tax:10116)	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of amylin by insulin-degrading_enzyme .
24898650	0	amyloid-b_protein_precursor	14,41	HspB1	56,61	amyloid-b protein precursor	HspB1	351	3315	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression Modulation|nmod|END_ENTITY	Modulation of amyloid-b_protein_precursor expression by HspB1 .
25758563	0	amyloid-b_protein_precursor	42,69	LINGO-1	0,7	amyloid-b protein precursor	LINGO-1	351	84894	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	LINGO-1 promotes lysosomal degradation of amyloid-b_protein_precursor .
16308488	0	amyloid_beta_precursor_protein	15,45	AbetaPP	47,54	amyloid beta precursor protein	AbetaPP	351	351	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of amyloid_beta_precursor_protein -LRB- AbetaPP -RRB- modulated copper_homeostasis in Alzheimer 's _ disease .
21825135	0	amyloid_precursor_protein	42,67	ADP_ribosylation_factor_6	0,25	amyloid precursor protein	ADP ribosylation factor 6	351	382	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	ADP_ribosylation_factor_6 -LRB- ARF6 -RRB- controls amyloid_precursor_protein -LRB- APP -RRB- processing by mediating the endosomal sorting of BACE1 .
10051452	0	amyloid_precursor_protein	106,131	APP	133,136	amyloid precursor protein	APP	351	351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Amyloid_precursor_protein metabolism in fibroblasts from individuals with one , two or three copies of the amyloid_precursor_protein -LRB- APP -RRB- gene .
11238715	0	amyloid_precursor_protein	27,52	APP	54,57	amyloid precursor protein	APP	351	351	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	A dinucleotide deletion in amyloid_precursor_protein -LRB- APP -RRB- mRNA associated with sporadic Alzheimer 's _ disease results in efficient secretion of truncated APP isoforms from neuroblastoma cell cultures .
15684649	0	amyloid_precursor_protein	18,43	APP	45,48	amyloid precursor protein	APP	101111593	101111593	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Downregulation of amyloid_precursor_protein -LRB- APP -RRB- expression following post-traumatic cyclosporin-A administration .
16458426	0	amyloid_precursor_protein	50,75	APP	77,80	amyloid precursor protein	APP	351	351	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The repressive effect of green tea ingredients on amyloid_precursor_protein -LRB- APP -RRB- expression in oral_carcinoma cells in vitro and in vivo .
17651731	0	amyloid_precursor_protein	56,81	APP	83,86	amyloid precursor protein	APP	351	351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	AP-2 participates in the transcriptional control of the amyloid_precursor_protein -LRB- APP -RRB- gene in oral_squamous_cell_carcinoma .
1899371	0	amyloid_precursor_protein	27,52	APP	54,57	amyloid precursor protein	APP	351	351	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulatory region of human amyloid_precursor_protein -LRB- APP -RRB- gene promotes neuron-specific gene expression in the CNS of transgenic_mice .
19097908	0	amyloid_precursor_protein	27,52	APP	54,57	amyloid precursor protein	APP	351	351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel polymorphisms of the amyloid_precursor_protein -LRB- APP -RRB- gene in Chinese/Taiwanese patients with Alzheimer 's _ disease .
22245578	0	amyloid_precursor_protein	56,81	APP	83,86	amyloid precursor protein	APP	351	351	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Metal binding dictates conformation and function of the amyloid_precursor_protein -LRB- APP -RRB- E2 domain .
7747597	0	amyloid_precursor_protein	14,39	APP	41,44	amyloid precursor protein	APP	54226(Tax:10116)	54226(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of amyloid_precursor_protein -LRB- APP -RRB- in rat brain and cultured neural cells .
8015372	0	amyloid_precursor_protein	55,80	APP	82,85	amyloid precursor protein	APP	351	351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Protein-DNA interactions in the promoter region of the amyloid_precursor_protein -LRB- APP -RRB- gene in human neocortex .
8611030	0	amyloid_precursor_protein	25,50	APP	52,55	amyloid precursor protein	APP	351	351	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Suppression of Alzheimer amyloid_precursor_protein -LRB- APP -RRB- expression by exogenous APP mRNA .
8738146	0	amyloid_precursor_protein	13,38	APP	40,43	amyloid precursor protein	APP	54226(Tax:10116)	54226(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Two types of amyloid_precursor_protein -LRB- APP -RRB- mRNA in rat glioma cell lines : upregulation via a cyclic_AMP-dependent pathway .
8917100	0	amyloid_precursor_protein	81,106	APP	108,111	amyloid precursor protein	APP	351	351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of cis-acting elements involved in an alternative splicing of the amyloid_precursor_protein -LRB- APP -RRB- gene .
20704561	0	amyloid_precursor_protein	68,93	ATP-binding_cassette_transporter-2	4,38	amyloid precursor protein	ATP-binding cassette transporter-2	351	20	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	The ATP-binding_cassette_transporter-2 -LRB- ABCA2 -RRB- increases endogenous amyloid_precursor_protein expression and Ab fragment generation .
7575468	0	amyloid_precursor_protein	24,49	A_beta	53,59	amyloid precursor protein	A beta	351	351	Gene	Gene	START_ENTITY|nmod|peptides peptides|compound|END_ENTITY	Lysosomal processing of amyloid_precursor_protein to A_beta peptides : a distinct role for cathepsin_S .
16027166	0	amyloid_precursor_protein	20,45	BRI2	0,4	amyloid precursor protein	BRI2	351	9445	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRI2 interacts with amyloid_precursor_protein -LRB- APP -RRB- and regulates amyloid beta -LRB- Abeta -RRB- production .
19366692	0	amyloid_precursor_protein	14,39	BRI2	121,125	amyloid precursor protein	BRI2	11820(Tax:10090)	16432(Tax:10090)	Gene	Gene	processing|compound|START_ENTITY inhibits|dobj|processing inhibits|nmod|manner manner|nmod|END_ENTITY	BRI3 inhibits amyloid_precursor_protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2 .
20036644	0	amyloid_precursor_protein	156,181	Bri2	28,32	amyloid precursor protein	Bri2	351	9445	Gene	Gene	processing|nmod|START_ENTITY binds|nmod|processing binds|nsubj|domain domain|nmod|END_ENTITY	The extracellular domain of Bri2 -LRB- ITM2B -RRB- binds the ABri peptide -LRB- 1-23 -RRB- and amyloid_beta-peptide -LRB- Abeta1-40 -RRB- : Implications for Bri2 effects on processing of amyloid_precursor_protein and Abeta_aggregation .
25773675	0	amyloid_precursor_protein	16,41	CHIP	0,4	amyloid precursor protein	CHIP	351	358	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	CHIP stabilizes amyloid_precursor_protein via proteasomal degradation and p53-mediated trans-repression of b-secretase .
20828718	0	amyloid_precursor_protein	93,118	CSF	79,82	amyloid precursor protein	CSF	351	1437	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Biochemical studies in Normal Pressure Hydrocephalus -LRB- NPH -RRB- patients : change in CSF levels of amyloid_precursor_protein -LRB- APP -RRB- , amyloid-beta -LRB- Ab -RRB- peptide and phospho-tau .
25838500	0	amyloid_precursor_protein	49,74	DR6	25,28	amyloid precursor protein	DR6	351	27242	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The crystal structure of DR6 in complex with the amyloid_precursor_protein provides insight into death receptor activation .
12837293	0	amyloid_precursor_protein	14,39	ERK1/2	83,89	amyloid precursor protein	ERK1/2	351	5595;5594	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of amyloid_precursor_protein expression and secretion via activation of ERK1/2 by hepatocyte_growth_factor in HEK293 cells transfected with APP751 .
24469452	0	amyloid_precursor_protein	39,64	F-box_only_protein_2	0,20	amyloid precursor protein	F-box only protein 2	11820(Tax:10090)	230904(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	F-box_only_protein_2 -LRB- Fbxo2 -RRB- regulates amyloid_precursor_protein levels and processing .
20700539	0	amyloid_precursor_protein	17,42	FAD	0,3	amyloid precursor protein	FAD	351	5663	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	FAD mutations in amyloid_precursor_protein do not directly perturb intracellular calcium homeostasis .
24499793	0	amyloid_precursor_protein	52,77	FKBP12	0,6	amyloid precursor protein	FKBP12	351	2282	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	FKBP12 regulates the localization and processing of amyloid_precursor_protein in human cell lines .
18387811	0	amyloid_precursor_protein	32,57	Homer2	0,6	amyloid precursor protein	Homer2	351	9455	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Homer2 and Homer3 interact with amyloid_precursor_protein and inhibit Abeta production .
11245675	0	amyloid_precursor_protein	95,120	Insulin-like_growth_factor_I	0,28	amyloid precursor protein	Insulin-like growth factor I	351	3479	Gene	Gene	apoptosis|nmod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- protects cells from apoptosis by Alzheimer 's V642I mutant amyloid_precursor_protein through IGF-I_receptor in an IGF-binding protein-sensitive manner .
19317852	0	amyloid_precursor_protein	76,101	Interleukin-1beta	0,17	amyloid precursor protein	Interleukin-1beta	351	24494(Tax:10116)	Gene	Gene	processing|compound|START_ENTITY enhances|dobj|processing enhances|nsubj|END_ENTITY	Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid_precursor_protein processing in rat primary cortical neurons via up-regulation of the P2Y -LRB- 2 -RRB- receptor .
22734645	0	amyloid_precursor_protein	42,67	LDLR-related_protein_10	0,23	amyloid precursor protein	LDLR-related protein 10	351	26020	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	LDLR-related_protein_10 -LRB- LRP10 -RRB- regulates amyloid_precursor_protein -LRB- APP -RRB- trafficking and processing : evidence for a role in Alzheimer 's _ disease .
26592823	0	amyloid_precursor_protein	64,89	MiR-16	0,6	amyloid precursor protein	MiR-16	54226(Tax:10116)	100313997(Tax:10116)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-16 regulates cell death in Alzheimer 's _ disease by targeting amyloid_precursor_protein .
25119742	0	amyloid_precursor_protein	32,57	MicroRNA-193b	0,13	amyloid precursor protein	MicroRNA-193b	351	574455	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MicroRNA-193b is a regulator of amyloid_precursor_protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer 's _ disease .
12960155	0	amyloid_precursor_protein	25,50	Notch1	0,6	amyloid precursor protein	Notch1	351	4851	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Notch1 competes with the amyloid_precursor_protein for gamma-secretase and down-regulates presenilin-1 gene expression .
16175584	0	amyloid_precursor_protein	27,52	Notch_1	0,7	amyloid precursor protein	Notch 1	351	4851	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Notch_1 interacts with the amyloid_precursor_protein in a Numb-independent manner .
10525535	0	amyloid_precursor_protein	52,77	Presenilin_1	0,12	amyloid precursor protein	Presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	processing|nmod|START_ENTITY controls|dobj|processing controls|nsubj|END_ENTITY	Presenilin_1 controls gamma-secretase processing of amyloid_precursor_protein in pre-golgi compartments of hippocampal neurons .
11406116	0	amyloid_precursor_protein	32,57	Presenilin_1	0,12	amyloid precursor protein	Presenilin 1	398223(Tax:8355)	399258(Tax:8355)	Gene	Gene	production|compound|START_ENTITY increase|dobj|production increase|nsubj|mutations mutations|amod|END_ENTITY	Presenilin_1 mutations increase amyloid_precursor_protein production and proteolysis in Xenopus_laevis oocytes .
10235452	0	amyloid_precursor_protein	56,81	Thrombin	0,8	amyloid precursor protein	Thrombin	351	2147	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Thrombin induces surface and intracellular secretion of amyloid_precursor_protein from human endothelial cells .
18575606	0	amyloid_precursor_protein	55,80	X11_and_ubiquilin	8,25	amyloid precursor protein	X11 and ubiquilin	31002(Tax:7227)	252671;32977	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of X11_and_ubiquilin as in vivo regulators of the amyloid_precursor_protein in Drosophila .
23897820	0	amyloid_precursor_protein	4,29	acetylcholinesterase	54,74	amyloid precursor protein	acetylcholinesterase	351	43	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|nmod|END_ENTITY	The amyloid_precursor_protein represses expression of acetylcholinesterase in neuronal cell lines .
12837293	0	amyloid_precursor_protein	14,39	hepatocyte_growth_factor	93,117	amyloid precursor protein	hepatocyte growth factor	351	3082	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of amyloid_precursor_protein expression and secretion via activation of ERK1/2 by hepatocyte_growth_factor in HEK293 cells transfected with APP751 .
19668572	0	amyloid_precursor_protein	55,80	interleukin-1beta	24,41	amyloid precursor protein	interleukin-1beta	54226(Tax:10116)	24494(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of interleukin-1beta and S100B on amyloid_precursor_protein in rat retinal neurons .
25119742	0	amyloid_precursor_protein	32,57	microRNA-193b	112,125	amyloid precursor protein	microRNA-193b	351	574455	Gene	Gene	START_ENTITY|nmod|fluid fluid|acl|derived derived|ccomp|biomarker biomarker|nsubj|END_ENTITY	MicroRNA-193b is a regulator of amyloid_precursor_protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer 's _ disease .
21691800	0	amyloid_precursor_protein	25,50	neural_cell_adhesion_molecule	78,107	amyloid precursor protein	neural cell adhesion molecule	351	4684	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Selective interaction of amyloid_precursor_protein with different isoforms of neural_cell_adhesion_molecule .
17608641	0	amyloid_precursor_protein	19,44	p53	65,68	amyloid precursor protein	p53	351	7157	Gene	Gene	Over-expression|nmod|START_ENTITY alters|nsubj|Over-expression alters|dobj|state state|nummod|END_ENTITY	Over-expression of amyloid_precursor_protein in HEK cells alters p53 conformational state and protects against doxorubicin .
19049493	0	amyloid_precursor_protein	54,79	p53	22,25	amyloid precursor protein	p53	351	7157	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The tumour suppressor p53 regulates the expression of amyloid_precursor_protein -LRB- APP -RRB- .
12960155	0	amyloid_precursor_protein	25,50	presenilin-1	90,102	amyloid precursor protein	presenilin-1	351	5663	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Notch1 competes with the amyloid_precursor_protein for gamma-secretase and down-regulates presenilin-1 gene expression .
12460547	0	amyloid_precursor_protein	54,79	presenilin_1	11,23	amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	delivery|nmod|START_ENTITY regulating|dobj|delivery END_ENTITY|acl|regulating	A role for presenilin_1 in regulating the delivery of amyloid_precursor_protein to the cell surface .
12831872	0	amyloid_precursor_protein	65,90	presenilin_1	91,103	amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	double-transgenic_mice|compound|START_ENTITY double-transgenic_mice|amod|END_ENTITY	Diffuse_amyloid_deposition , but not plaque number , is reduced in amyloid_precursor_protein / presenilin_1 double-transgenic_mice by pathway lesions .
15772361	0	amyloid_precursor_protein	126,151	presenilin_1	29,41	amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	mutations|nmod|START_ENTITY mutations|nsubj|END_ENTITY	Familial_Alzheimer 's _ disease presenilin_1 mutations cause alterations in the conformation of presenilin and interactions with amyloid_precursor_protein .
18304749	0	amyloid_precursor_protein	61,86	presenilin_1	87,99	amyloid precursor protein	presenilin 1	351	19164(Tax:10090)	Gene	Gene	model|amod|START_ENTITY model|amod|END_ENTITY	Acquisition of conditioned taste aversion is impaired in the amyloid_precursor_protein / presenilin_1 mouse model of Alzheimer 's _ disease .
18583063	0	amyloid_precursor_protein	125,150	presenilin_1	151,163	amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	gyrus|nmod|START_ENTITY immunoreactivity|nmod|gyrus depletion|nmod|immunoreactivity /|nsubj|depletion /|dobj|transgenic_mice transgenic_mice|amod|END_ENTITY	Subfield and layer-specific depletion in calbindin-D28K , calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid_precursor_protein / presenilin_1 transgenic_mice .
19181896	0	amyloid_precursor_protein	119,144	presenilin_1	12,24	amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	affecting|dobj|START_ENTITY impair|advcl|affecting impair|nsubj|Increase Increase|nmod|levels levels|amod|END_ENTITY	Increase in presenilin_1 -LRB- PS1 -RRB- levels in senescence-accelerated mice -LRB- SAMP8 -RRB- may indirectly impair memory by affecting amyloid_precursor_protein -LRB- APP -RRB- processing .
20921220	0	amyloid_precursor_protein	116,141	presenilin_1	25,37	amyloid precursor protein	presenilin 1	351	5663	Gene	Gene	substrates|amod|START_ENTITY activity|nmod|substrates spectrum|nmod|activity reveals|dobj|spectrum reveals|nsubj|analysis analysis|nmod|domain domain|amod|END_ENTITY	Mutation analysis of the presenilin_1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid_precursor_protein and other substrates .
22702220	0	amyloid_precursor_protein	122,147	presenilin_1	148,160	amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer 's _ disease -LSB- amyloid_precursor_protein / presenilin_1 -LRB- PS1 -RRB- -RSB- .
26293690	0	amyloid_precursor_protein	172,197	presenilin_1	198,210	amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|amod|END_ENTITY	By suppressing the expression of anterior_pharynx-defective-1a_and _ -1 b and inhibiting the aggregation of b-amyloid protein , magnesium ions inhibit the cognitive_decline of amyloid_precursor_protein / presenilin_1 transgenic_mice .
9486481	0	amyloid_precursor_protein	88,113	protein_kinase_C_alpha	18,40	amyloid precursor protein	protein kinase C alpha	351	5578	Gene	Gene	secretion|nmod|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	Specific role for protein_kinase_C_alpha in the constitutive and regulated secretion of amyloid_precursor_protein in human skin fibroblasts .
21829538	0	amyloid_precursor_protein	15,40	semaphorin_3a	47,60	amyloid precursor protein	semaphorin 3a	351	10371	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	Secreted human amyloid_precursor_protein binds semaphorin_3a and prevents semaphorin-induced growth cone collapse .
16604305	0	anaplastic_lymphoma_kinase	64,90	ALK	92,95	anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible association between nonsynonymous polymorphisms of the anaplastic_lymphoma_kinase -LRB- ALK -RRB- gene and schizophrenia in a Japanese population .
20632993	0	anaplastic_lymphoma_kinase	30,56	ALK	25,28	anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Crystal structure of the ALK -LRB- anaplastic_lymphoma_kinase -RRB- catalytic domain .
22280150	0	anaplastic_lymphoma_kinase	60,86	ALK	88,91	anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inflammatory_myofibroblastic_tumor of the lung in children : anaplastic_lymphoma_kinase -LRB- ALK -RRB- expression and clinico-pathological correlation .
22705117	0	anaplastic_lymphoma_kinase	115,141	ALK	143,146	anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiparametric molecular characterization of pulmonary_sarcomatoid_carcinoma reveals a nonrandom amplification of anaplastic_lymphoma_kinase -LRB- ALK -RRB- gene .
23050789	0	anaplastic_lymphoma_kinase	11,37	ALK	39,42	anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rearranged anaplastic_lymphoma_kinase -LRB- ALK -RRB- gene in adult-onset papillary_thyroid_cancer amongst atomic bomb survivors .
23880539	0	anaplastic_lymphoma_kinase	31,57	ALK	59,62	anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of 7-azaindole based anaplastic_lymphoma_kinase -LRB- ALK -RRB- inhibitors : wild type and mutant -LRB- L1196M -RRB- active compounds with unique binding mode .
25200979	0	anaplastic_lymphoma_kinase	105,131	ALK	133,136	anaplastic lymphoma kinase	ALK	238	238	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design , synthesis and pharmacological evaluation of 2 - -LRB- thiazol-2-amino -RRB- -4 - arylaminopyrimidines as potent anaplastic_lymphoma_kinase -LRB- ALK -RRB- inhibitors .
26130408	0	anaplastic_lymphoma_kinase	95,121	ALK	123,126	anaplastic lymphoma kinase	ALK	266802(Tax:10116)	266802(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of 2-arylamino-4 - -LRB- 1-methyl-3-isopropylsulfonyl-4-pyrazol-amino -RRB- pyrimidines as potent anaplastic_lymphoma_kinase -LRB- ALK -RRB- inhibitors .
7736780	0	anaplastic_lymphoma_kinase	42,68	AlK	70,73	anaplastic lymphoma kinase	AlK	11682(Tax:10090)	11682(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the murine homolog of the anaplastic_lymphoma_kinase -LRB- AlK -RRB- gene on mouse chromosome 17 .
22940020	0	anaplastic_lymphoma_kinase	20,46	CD30	13,17	anaplastic lymphoma kinase	CD30	238	943	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Two cases of CD30 + , anaplastic_lymphoma_kinase -LRB- ALK -RRB- - negative anaplastic_large_cell_lymphoma with oral manifestations .
1397263	0	anchorin_CII	21,33	annexin_V	35,44	anchorin CII	annexin V	308	308	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Selective binding of anchorin_CII -LRB- annexin_V -RRB- to type II and X collagen and to chondrocalcin -LRB- C-propeptide of type II collagen -RRB- .
21857022	0	ancient_ubiquitous_protein_1	13,41	AUP1	43,47	ancient ubiquitous protein 1	AUP1	550	550	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Dual role of ancient_ubiquitous_protein_1 -LRB- AUP1 -RRB- in lipid droplet accumulation and endoplasmic reticulum -LRB- ER -RRB- protein quality control .
17854663	0	and_1p	44,50	TP53	0,4	and 1p	TP53	11169	7157	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	TP53 codon 72 polymorphism , p53 expression , and_1p / 19q status in oligodendroglial_tumors .
12573823	0	androgen-binding_protein	11,35	ABP	37,40	androgen-binding protein	ABP	24775(Tax:10116)	24775(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of androgen-binding_protein -LRB- ABP -RRB- on spermatid Tnp1 gene expression in vitro .
16700002	0	androgen-binding_protein	14,38	ABP	40,43	androgen-binding protein	ABP	6462	6462	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of androgen-binding_protein -LRB- ABP -RRB- in human cardiac myocytes .
3135485	0	androgen-binding_protein	27,51	ABP	53,56	androgen-binding protein	ABP	24775(Tax:10116)	24775(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Hormonal regulation of rat androgen-binding_protein -LRB- ABP -RRB- messenger ribonucleic acid and homology of human testosterone-estradiol-binding globulin and ABP complementary deoxyribonucleic acids .
9002628	0	androgen-binding_protein	31,55	sex_hormone-binding_globulin	56,84	androgen-binding protein	sex hormone-binding globulin	11354(Tax:10090)	20415(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression and distribution of androgen-binding_protein / sex_hormone-binding_globulin in the female rodent reproductive system .
7980556	0	androgen-induced_growth_factor	15,45	FGF-8	47,52	androgen-induced growth factor	FGF-8	14179(Tax:10090)	14179(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Involvement of androgen-induced_growth_factor -LRB- FGF-8 -RRB- gene in mouse embryogenesis and morphogenesis .
7772520	0	androgen-receptor	174,191	HUMARA	193,199	androgen-receptor	HUMARA	367	367	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clonal analysis of peripheral blood and haemopoietic colonies in patients with aplastic_anaemia and refractory_anaemia using the polymorphic short tandem repeat on the human androgen-receptor -LRB- HUMARA -RRB- gene .
3604700	0	androgen_binding_protein	59,83	hCG	16,19	androgen binding protein	hCG	24775(Tax:10116)	3342	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Acute effect of hCG on testicular and epididymal levels of androgen_binding_protein -LRB- ABP -RRB- in the immature rat .
10583164	0	androgen_receptor	23,40	5alpha-reductase	42,58	androgen receptor	5alpha-reductase	367	6715	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Expression of mRNA for androgen_receptor , 5alpha-reductase and 17beta-hydroxysteroid_dehydrogenase in human dermal_papilla cells .
10567563	0	androgen_receptor	31,48	AF1	4,7	androgen receptor	AF1	367	3460	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	The AF1 and AF2 domains of the androgen_receptor interact with distinct regions of SRC1 .
15023052	0	androgen_receptor	44,61	AF1	33,36	androgen receptor	AF1	367	3460	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Induced alpha-helix structure in AF1 of the androgen_receptor upon binding transcription factor TFIIF .
19318566	0	androgen_receptor	53,70	ANCCA	29,34	androgen receptor	ANCCA	367	29028	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Androgen-induced coactivator ANCCA mediates specific androgen_receptor signaling in prostate_cancer .
10493597	0	androgen_receptor	31,48	AR	50,52	androgen receptor	AR	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of size-polymorphic androgen_receptor -LRB- AR -RRB- gene in ovarian_endometriosis according to the number of cytosine , adenine , and guanine -LRB- CAG -RRB- repeats in AR alleles .
11875111	0	androgen_receptor	14,31	AR	33,35	androgen receptor	AR	367	367	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of androgen_receptor -LRB- AR -RRB- function by the reproductive orphan nuclear receptor DAX-1 .
12600293	0	androgen_receptor	42,59	AR	61,63	androgen receptor	AR	367	367	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	-LSB- Significance of both nuclear and cytosol androgen_receptor -LRB- AR -RRB- in assessment of AR status in prostate_carcinoma and hepatocellular_carcinoma -RSB- .
14693242	0	androgen_receptor	35,52	AR	59,61	androgen receptor	AR	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The CAG repeat polymorphism in the androgen_receptor gene -LRB- AR -RRB- and its relationship to head_and_neck_cancer .
15876692	0	androgen_receptor	31,48	AR	50,52	androgen receptor	AR	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	CAG repeat polymorphism in the androgen_receptor -LRB- AR -RRB- gene of SBMA patients and a control group .
16804045	0	androgen_receptor	52,69	AR	71,73	androgen receptor	AR	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The A645D mutation in the hinge region of the human androgen_receptor -LRB- AR -RRB- gene modulates AR activity , depending on the context of the polymorphic glutamine and glycine repeats .
17482664	0	androgen_receptor	36,53	AR	55,57	androgen receptor	AR	367	367	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Tissue-specific distribution of the androgen_receptor -LRB- AR -RRB- in the porcine fetus .
22428303	0	androgen_receptor	52,69	AR	71,73	androgen receptor	AR	397582(Tax:9823)	397582(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prenatal exposure to antiandrogen_flutamide affects androgen_receptor -LRB- AR -RRB- expression in postnatal ovarian development in pig .
23012352	0	androgen_receptor	44,61	AR	63,65	androgen receptor	AR	11835(Tax:10090)	11835(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Targeting the unique methylation pattern of androgen_receptor -LRB- AR -RRB- promoter in prostate stem/progenitor cells with 5-aza-2 ' - deoxycytidine -LRB- 5-AZA -RRB- leads to suppressed prostate tumorigenesis .
23591144	0	androgen_receptor	87,104	AR	106,108	androgen receptor	AR	367	367	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Reciprocal interaction between melatonin receptors -LRB- Mel -LRB- 1a -RRB- , Mel -LRB- 1b -RRB- , and Mel -LRB- 1c -RRB- -RRB- and androgen_receptor -LRB- AR -RRB- expression in immunoregulation of a seasonally breeding bird , Perdicula asiatica : role of photoperiod .
24799883	0	androgen_receptor	58,75	AR	77,79	androgen receptor	AR	367	367	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	New single nucleotide variation in the promoter region of androgen_receptor -LRB- AR -RRB- gene in hypospadic patients .
24820830	0	androgen_receptor	73,90	AR	92,94	androgen receptor	AR	367	367	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Contribution of allelic variability in prostate_specific_antigen -LRB- PSA -RRB- _ androgen_receptor -LRB- AR -RRB- genes to serum PSA levels in men with prostate_cancer .
25438607	0	androgen_receptor	35,52	AR	59,61	androgen receptor	AR	367	367	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	-LSB- Molecular genetic polymorphism of androgen_receptor gene -LRB- AR -RRB- in African populations of Hadza and Datoga -RSB- .
25508138	0	androgen_receptor	35,52	AR	59,61	androgen receptor	AR	367	367	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	-LSB- Molecular genetic polymorphism of androgen_receptor gene -LRB- AR -RRB- in African populations of Hadza and Datoga -RSB- .
7608480	0	androgen_receptor	62,79	AR	81,83	androgen receptor	AR	367	367	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Effect of androgens and their manipulation on cell growth and androgen_receptor -LRB- AR -RRB- levels in AR-positive_and _ - negative_human_hepatocellular_carcinomas .
7658727	0	androgen_receptor	104,121	AR	123,125	androgen receptor	AR	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Quantitative non-radioactive clonality analysis of human leukemic cells and progenitors using the human androgen_receptor -LRB- AR -RRB- gene .
8329186	0	androgen_receptor	13,30	AR	32,34	androgen receptor	AR	367	367	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Detection of androgen_receptor -LRB- AR -RRB- mRNA by the reverse transcription polymerase chain reaction -LRB- RT-PCR -RRB- in human thyroids .
17408421	0	androgen_receptor	88,105	AR-A	71,75	androgen receptor	AR-A	367	368	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	Complete_androgen_insensitivity without Wolffian_duct development : the AR-A form of the androgen_receptor is not sufficient for male genital development .
12058073	0	androgen_receptor	56,73	ATPase	6,12	androgen receptor	ATPase	367	1769	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Novel ATPase of SNF2-like protein family interacts with androgen_receptor and modulates androgen-dependent transcription .
19325002	0	androgen_receptor	101,118	ATPase	34,40	androgen receptor	ATPase	367	1769	Gene	Gene	function|compound|START_ENTITY enhances|dobj|function enhances|nsubj|Tat-binding_protein-1 Tat-binding_protein-1|appos|END_ENTITY	Tat-binding_protein-1 -LRB- TBP-1 -RRB- , an ATPase of 19S regulatory particles of the 26S proteasome , enhances androgen_receptor function in cooperation with TBP-1-interacting_protein / Hop2 .
17356171	0	androgen_receptor	31,48	Alien	0,5	androgen receptor	Alien	367	9318	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Alien interacts with the human androgen_receptor and inhibits_prostate_cancer cell growth .
23811403	0	androgen_receptor	46,63	Ankrd1	0,6	androgen receptor	Ankrd1	11835(Tax:10090)	107765(Tax:10090)	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Ankrd1 is a transcriptional repressor for the androgen_receptor that is downregulated by testosterone .
20713353	0	androgen_receptor	34,51	Aurora-A	55,63	androgen receptor	Aurora-A	367	6790	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of androgen_receptor by Aurora-A .
10987273	0	androgen_receptor	21,38	Beta-catenin	0,12	androgen receptor	Beta-catenin	367	1499	Gene	Gene	activity|compound|START_ENTITY affects|dobj|activity affects|nsubj|END_ENTITY	Beta-catenin affects androgen_receptor transcriptional activity and ligand specificity .
12588987	0	androgen_receptor	62,79	Beta-catenin	0,12	androgen receptor	Beta-catenin	367	1499	Gene	Gene	region|nmod|START_ENTITY binds|nmod|region binds|nsubj|END_ENTITY	Beta-catenin binds to the activation_function_2 region of the androgen_receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription .
15514031	0	androgen_receptor	89,106	Beta-catenin	0,12	androgen receptor	Beta-catenin	367	1499	Gene	Gene	transactivation|nmod|START_ENTITY involved|nmod|transactivation involved|nsubjpass|END_ENTITY	Beta-catenin is involved in insulin-like_growth_factor_1-mediated transactivation of the androgen_receptor .
18819102	0	androgen_receptor	24,41	CBP/p300	50,58	androgen receptor	CBP/p300	367	1387;2033	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	Interleukin-4 activates androgen_receptor through CBP/p300 .
21350948	0	androgen_receptor	30,47	CD8	0,3	androgen receptor	CD8	367	925	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	CD8 + T cells specific for the androgen_receptor are common in patients with prostate_cancer and are able to lyse_prostate_tumor cells .
15107424	0	androgen_receptor	3,20	CHIP	117,121	androgen receptor	CHIP	367	358	Gene	Gene	NH2-terminal|compound|START_ENTITY conserved|nsubj|NH2-terminal conserved|nmod|COOH_terminus_of_the_Hsp70-interacting_protein COOH_terminus_of_the_Hsp70-interacting_protein|appos|END_ENTITY	An androgen_receptor NH2-terminal conserved motif interacts with the COOH_terminus_of_the_Hsp70-interacting_protein -LRB- CHIP -RRB- .
16725394	0	androgen_receptor	39,56	CHIP	24,28	androgen receptor	CHIP	367	358	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The E3 ubiquitin ligase CHIP binds the androgen_receptor in a phosphorylation-dependent manner .
22174412	0	androgen_receptor	21,38	CYP17	58,63	androgen receptor	CYP17	367	1586	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Direct regulation of androgen_receptor activity by potent CYP17 inhibitors in prostate_cancer cells .
22924551	0	androgen_receptor	9,26	CYP17	69,74	androgen receptor	CYP17	367	1586	Gene	Gene	flexibility|compound|START_ENTITY flexibility|dep|hypothesis hypothesis|nmod|inhibitors/antiandrogens inhibitors/antiandrogens|nummod|END_ENTITY	Modeling androgen_receptor flexibility : a binding mode hypothesis of CYP17 inhibitors/antiandrogens for prostate_cancer therapy .
23603339	0	androgen_receptor	82,99	CYP1A2	55,61	androgen receptor	CYP1A2	367	1544	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen_receptor .
21506119	0	androgen_receptor	20,37	Calmodulin	0,10	androgen receptor	Calmodulin	367	808	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Calmodulin protects androgen_receptor from calpain-mediated breakdown in prostate_cancer cells .
11278309	0	androgen_receptor	26,43	Caveolin-1	0,10	androgen receptor	Caveolin-1	367	857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Caveolin-1 interacts with androgen_receptor .
11085988	0	androgen_receptor	47,64	Cdc37	32,37	androgen receptor	Cdc37	367	11140	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of human Cdc37 with the androgen_receptor but not with the glucocorticoid_receptor .
23281476	0	androgen_receptor	94,111	Cdc37	43,48	androgen receptor	Cdc37	367	11140	Gene	Gene	activity|compound|START_ENTITY promotes|dobj|activity promotes|nsubj|interaction interaction|nmod|END_ENTITY	Novel interaction between the co-chaperone Cdc37 and Rho GTPase exchange factor Vav3 promotes androgen_receptor activity and prostate_cancer growth .
24845031	0	androgen_receptor	49,66	Chrebp	0,6	androgen receptor	Chrebp	367	51085	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Chrebp regulates the transcriptional activity of androgen_receptor in prostate_cancer .
25447311	0	androgen_receptor	39,56	Coagulation_factor_VII	0,22	androgen receptor	Coagulation factor VII	367	2155	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Coagulation_factor_VII is regulated by androgen_receptor in breast_cancer .
11328859	0	androgen_receptor	20,37	Cyclin_D1	0,9	androgen receptor	Cyclin D1	367	595	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cyclin_D1 binds the androgen_receptor and regulates hormone-dependent signaling in a p300/CBP-associated _ factor -LRB- P/CAF -RRB- - dependent manner .
11714699	0	androgen_receptor	40,57	Cyclin_D1	0,9	androgen receptor	Cyclin D1	367	595	Gene	Gene	activity|compound|START_ENTITY mechanism|nmod|activity END_ENTITY|dep|mechanism	Cyclin_D1 : mechanism and consequence of androgen_receptor co-repressor activity .
15539430	0	androgen_receptor	25,42	Cyclin_D1	0,9	androgen receptor	Cyclin D1	367	595	Gene	Gene	binding|nmod|START_ENTITY binding|advmod|END_ENTITY	Cyclin_D1 binding to the androgen_receptor -LRB- AR -RRB- NH2-terminal domain inhibits activation function 2 association and reveals dual roles for AR corepression .
11477070	0	androgen_receptor	30,47	DJ-1	0,4	androgen receptor	DJ-1	367	11315	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	DJ-1 positively regulates the androgen_receptor by impairing the binding of PIASx_alpha to the receptor .
15056870	0	androgen_receptor	47,64	DJ-1	21,25	androgen receptor	DJ-1	24208(Tax:10116)	117287(Tax:10116)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|Co-localization Co-localization|nmod|END_ENTITY	Co-localization with DJ-1 is essential for the androgen_receptor to exert its transcription activity that has been impaired by androgen antagonists .
17510388	0	androgen_receptor	11,28	DJ-1	0,4	androgen receptor	DJ-1	367	11315	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	DJ-1 binds androgen_receptor directly and mediates its activity in hormonally treated prostate_cancer cells .
12612053	0	androgen_receptor	61,78	DJBP	0,4	androgen receptor	DJBP	11835(Tax:10090)	77627(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	DJBP : a novel DJ-1-binding protein , negatively regulates the androgen_receptor by recruiting histone deacetylase complex , and DJ-1 antagonizes this inhibition by abrogation of this complex .
18794357	0	androgen_receptor	10,27	E-cadherin	42,52	androgen receptor	E-cadherin	11835(Tax:10090)	12550(Tax:10090)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Activated androgen_receptor downregulates E-cadherin gene expression and promotes tumor metastasis .
21170267	0	androgen_receptor	20,37	ERG	0,3	androgen receptor	ERG	367	2078	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	ERG cooperates with androgen_receptor in regulating trefoil_factor_3 in prostate_cancer disease progression .
25899828	0	androgen_receptor	115,132	ERG	7,10	androgen receptor	ERG	367	2078	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|compound|END_ENTITY	Weaker ERG expression in patients with ERG-positive_prostate_cancer is associated with advanced_disease and weaker androgen_receptor expression : An Indian outlook .
20874728	0	androgen_receptor	57,74	ERK1/2	87,93	androgen receptor	ERK1/2	24208(Tax:10116)	50689;116590	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|dep|END_ENTITY	The anti-oestrogen fulvestrant -LRB- ICI_182 ,780 -RRB- reduces the androgen_receptor expression , ERK1/2 phosphorylation and cell proliferation in the rat ventral prostate .
19789348	0	androgen_receptor	67,84	ETS-related_protein_81	102,124	androgen receptor	ETS-related protein 81	367	2115	Gene	Gene	Induction|nmod|START_ENTITY Induction|parataxis|END_ENTITY	Induction of prostatic_intraepithelial_neoplasia and modulation of androgen_receptor by ETS_variant_1 / ETS-related_protein_81 .
19789348	0	androgen_receptor	67,84	ETS_variant_1	88,101	androgen receptor	ETS variant 1	367	2115	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of prostatic_intraepithelial_neoplasia and modulation of androgen_receptor by ETS_variant_1 / ETS-related_protein_81 .
12890669	0	androgen_receptor	39,56	Early_growth_response_gene_1	0,28	androgen receptor	Early growth response gene 1	367	1958	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Early_growth_response_gene_1 modulates androgen_receptor signaling in prostate_carcinoma cells .
18623111	0	androgen_receptor	44,61	Endothelin-1	0,12	androgen receptor	Endothelin-1	367	1906	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Endothelin-1 enhances the expression of the androgen_receptor via activation of the c-myc pathway in prostate_cancer cells .
14662770	0	androgen_receptor	54,71	Epidermal_growth_factor	0,23	androgen receptor	Epidermal growth factor	367	1950	Gene	Gene	coactivation|nmod|START_ENTITY increases|dobj|coactivation increases|nsubj|END_ENTITY	Epidermal_growth_factor increases coactivation of the androgen_receptor in recurrent prostate_cancer .
22922989	0	androgen_receptor	92,109	Epidermal_growth_factor	0,23	androgen receptor	Epidermal growth factor	367	1950	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces bladder_cancer cell proliferation through activation of the androgen_receptor .
24126741	0	androgen_receptor	33,50	Epidermal_growth_factor	0,23	androgen receptor	Epidermal growth factor	11835(Tax:10090)	13645(Tax:10090)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Epidermal_growth_factor enhances androgen_receptor - mediated bladder_cancer progression and invasion via potentiation of AR transactivation .
20587519	0	androgen_receptor	53,70	ErbB3	29,34	androgen receptor	ErbB3	367	2065	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Nrdp1-mediated regulation of ErbB3 expression by the androgen_receptor in androgen-dependent but not castrate-resistant prostate_cancer cells .
12140757	0	androgen_receptor	37,54	FGF8	14,18	androgen receptor	FGF8	367	2253	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of FGF8 expression by the androgen_receptor in human prostate_cancer .
21730179	0	androgen_receptor	28,45	FKBP52	97,103	androgen receptor	FKBP52	367	2288	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Targeting the regulation of androgen_receptor signaling by the heat_shock protein 90 cochaperone FKBP52 in prostate_cancer cells .
24292680	0	androgen_receptor	36,53	FOXA1	19,24	androgen receptor	FOXA1	367	3169	Gene	Gene	chromatin|compound|START_ENTITY resulting|nsubj|chromatin facilitate|xcomp|resulting facilitate|nsubj|levels levels|nmod|END_ENTITY	Elevated levels of FOXA1 facilitate androgen_receptor chromatin binding resulting in a CRPC-like phenotype .
24875621	0	androgen_receptor	52,69	FOXA1	35,40	androgen receptor	FOXA1	367	3169	Gene	Gene	program|compound|START_ENTITY define|dobj|program define|nsubj|Cooperativity Cooperativity|nmod|END_ENTITY	Cooperativity and equilibrium with FOXA1 define the androgen_receptor transcriptional program .
24948874	0	androgen_receptor	14,31	FOXA1	35,40	androgen receptor	FOXA1	367	3169	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|factors factors|compound|END_ENTITY	Modulation of androgen_receptor by FOXA1 and FOXO1 factors in prostate_cancer .
26114156	0	androgen_receptor	44,61	FOXA1	24,29	androgen receptor	FOXA1	367	3169	Gene	Gene	signaling|compound|START_ENTITY perspectives|nmod|signaling perspectives|nmod|regulation regulation|compound|END_ENTITY	Current perspectives on FOXA1 regulation of androgen_receptor signaling and prostate_cancer .
26336819	0	androgen_receptor	16,33	FOXA1	0,5	androgen receptor	FOXA1	367	3169	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	FOXA1 regulates androgen_receptor variant activity in models of castrate-resistant_prostate_cancer .
7577719	0	androgen_receptor	29,46	FSH_receptor	85,97	androgen receptor	FSH receptor	367	102135198	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Ubiquitous expression of the androgen_receptor and testis-specific expression of the FSH_receptor in the cynomolgus_monkey -LRB- Macaca_fascicularis -RRB- revealed by a ribonuclease protection assay .
21909421	0	androgen_receptor	29,46	FUS/TLS	0,7	androgen receptor	FUS/TLS	367	2521	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	FUS/TLS is a co-activator of androgen_receptor in prostate_cancer cells .
20605780	0	androgen_receptor	17,34	Fkbp52	0,6	androgen receptor	Fkbp52	11835(Tax:10090)	14228(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Fkbp52 regulates androgen_receptor transactivation activity and male urethra morphogenesis .
16467259	0	androgen_receptor	34,51	Foxa1	0,5	androgen receptor	Foxa1	11835(Tax:10090)	15375(Tax:10090)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Foxa1 and Foxa2 interact with the androgen_receptor to regulate prostate and epididymal genes differentially .
10234512	0	androgen_receptor	39,56	GGN	14,17	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY repeats|nmod|gene repeats|compound|END_ENTITY	-LRB- CAG -RRB- nCAA and GGN repeats in the human androgen_receptor gene are not associated with prostate_cancer in a French-German population .
12802043	0	androgen_receptor	46,63	GGN	64,67	androgen receptor	GGN	367	199720	Gene	Gene	mutations|nmod|START_ENTITY association|nmod|mutations END_ENTITY|nsubj|association	No association between mutations in the human androgen_receptor GGN repeat and inter-sex conditions .
15472213	0	androgen_receptor	74,91	GGN	49,52	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Linkage between cryptorchidism , hypospadias , and GGN repeat length in the androgen_receptor gene .
16809273	0	androgen_receptor	18,35	GGN	36,39	androgen receptor	GGN	367	199720	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	No association of androgen_receptor GGN repeat length polymorphism with infertility in Indian men .
16957138	0	androgen_receptor	70,87	GGN	40,43	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY exon|nmod|gene Association|nmod|exon Association|appos|repeats repeats|compound|END_ENTITY	Association of long polyglycine tracts -LRB- GGN repeats -RRB- in exon 1 of the androgen_receptor gene with cryptorchidism and penile_hypospadias in Iranian patients .
16969583	0	androgen_receptor	58,75	GGN	0,3	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY repeat|nmod|gene repeat|nsubj|END_ENTITY	GGN repeat length and GGN/CAG haplotype variations in the androgen_receptor gene and prostate_cancer risk in south Indian men .
17197074	0	androgen_receptor	44,61	GGN	62,65	androgen receptor	GGN	367	199720	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Functional in vitro characterisation of the androgen_receptor GGN polymorphism .
17601880	0	androgen_receptor	60,77	GGN	42,45	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY repeat|nmod|gene repeat|compound|END_ENTITY	The two most common alleles of the coding GGN repeat in the androgen_receptor gene cause differences in protein function .
19095061	0	androgen_receptor	63,80	GGN	22,25	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY exon-1|nmod|gene repeats|nmod|exon-1 repeats|compound|END_ENTITY	Short alleles of both GGN and CAG repeats at the exon-1 of the androgen_receptor gene are associated to increased PSA staining and a higher Gleason score in human prostatic_cancer .
19159685	0	androgen_receptor	58,75	GGN	4,7	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY exon-1|nmod|gene END_ENTITY|nmod|exon-1	The GGN and CAG repeat polymorphisms in the exon-1 of the androgen_receptor gene are , respectively , associated with insulin resistance in men and with dyslipidemia in women .
19383805	0	androgen_receptor	20,37	GGN	43,46	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY effect|nmod|gene END_ENTITY|nsubj|effect	Small effect of the androgen_receptor gene GGN repeat polymorphism on serum testosterone levels in healthy men .
24855036	0	androgen_receptor	28,45	GGN	58,61	androgen receptor	GGN	367	199720	Gene	Gene	survey|nmod|START_ENTITY n|nsubj|survey n|dep|END_ENTITY	A pharmacogenetic survey of androgen_receptor -LRB- CAG -RRB- n and -LRB- GGN -RRB- n polymorphisms in patients experiencing long term side effects after finasteride discontinuation .
25027083	0	androgen_receptor	21,38	GGN	45,48	androgen receptor	GGN	367	199720	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Associations between androgen_receptor CAG _ GGN repeat polymorphism _ recurrent spontaneous_abortions in Chinese women .
26221130	0	androgen_receptor	15,32	GGN	33,36	androgen receptor	GGN	367	199720	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of androgen_receptor GGN repeat length polymorphism and male_infertility in Khuzestan , Iran .
26221130	0	androgen_receptor	15,32	GGN	33,36	androgen receptor	GGN	367	199720	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of androgen_receptor GGN repeat length polymorphism and male_infertility in Khuzestan , Iran .
9385367	0	androgen_receptor	81,98	GGN	41,44	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY repeat|nmod|gene trinucleotide|dobj|repeat trinucleotide|nsubj|variants variants|nmod|n n|appos|END_ENTITY	Codon-usage variants in the polymorphic -LRB- GGN -RRB- n trinucleotide repeat of the human androgen_receptor gene .
9610786	0	androgen_receptor	4,21	GGN	27,30	androgen receptor	GGN	367	199720	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nsubj|gene	The androgen_receptor gene GGN microsatellite and prostate_cancer risk .
17553795	0	androgen_receptor	78,95	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	androgen receptor	Glyceraldehyde-3-phosphate dehydrogenase	367	2597	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase enhances transcriptional activity of androgen_receptor in prostate_cancer cells .
24191589	0	androgen_receptor	66,83	HER-2	52,57	androgen receptor	HER-2	367	2064	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	-LSB- Survival analysis and immunohistochemical study of HER-2 and AR -LRB- androgen_receptor -RRB- expression in salivary_duct_carcinoma -RSB- .
21454491	0	androgen_receptor	14,31	HEYL	44,48	androgen receptor	HEYL	367	26508	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Repression of androgen_receptor activity by HEYL , a third member of the Hairy/Enhancer-of-split - related family of Notch effectors .
21047772	0	androgen_receptor	15,32	HOXC8	0,5	androgen receptor	HOXC8	367	3224	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	HOXC8 inhibits androgen_receptor signaling in human prostate_cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes .
22362414	0	androgen_receptor	42,59	HSP27	33,38	androgen receptor	HSP27	367	3315	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effect of the heat_shock protein HSP27 on androgen_receptor expression and function in prostate_cancer cells .
10821498	0	androgen_receptor	155,172	HUMARA	179,185	androgen receptor	HUMARA	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular evidence that the stromal and epithelial cells in pleomorphic_adenomas of salivary gland arise from the same origin : clonal analysis using human androgen_receptor gene -LRB- HUMARA -RRB- assay .
11444663	0	androgen_receptor	60,77	HUMARA	84,90	androgen receptor	HUMARA	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Automated fluorescence analysis of CAG repeats at the human androgen_receptor gene -LRB- HUMARA -RRB- : evaluation of polymorphism in an Italian sample and report of a new allele .
9232621	0	androgen_receptor	64,81	HUMARA	88,94	androgen receptor	HUMARA	367	367	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Clonal X-inactivation analysis of human tumours using the human androgen_receptor gene -LRB- HUMARA -RRB- polymorphism : a non-radioactive and semiquantitative strategy applicable to fresh and archival tissue .
9729823	0	androgen_receptor	90,107	HUMARA	114,120	androgen receptor	HUMARA	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Development of a highly polymorphic STR marker for identity testing purposes at the human androgen_receptor gene -LRB- HUMARA -RRB- .
9778630	0	androgen_receptor	95,112	HUMARA	119,125	androgen receptor	HUMARA	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Clonal composition of malignant_fibrous_histiocytoma : analysis by PCR-based assay of the human androgen_receptor gene -LRB- HUMARA -RRB- .
10396290	0	androgen_receptor	64,81	Humara	88,94	androgen receptor	Humara	367	367	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Clonality analysis using X-chromosome inactivation at the human androgen_receptor gene -LRB- Humara -RRB- .
16782802	0	androgen_receptor	54,71	Huntingtin-associated_protein_1	0,31	androgen receptor	Huntingtin-associated protein 1	367	9001	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Huntingtin-associated_protein_1 -LRB- HAP1 -RRB- interacts with androgen_receptor -LRB- AR -RRB- and suppresses SBMA-mutant-AR-induced apoptosis .
21885566	0	androgen_receptor	48,65	ICAT	33,37	androgen receptor	ICAT	367	56998	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	The beta-catenin binding protein ICAT modulates androgen_receptor activity .
16541420	0	androgen_receptor	42,59	IGFBP-3	27,34	androgen receptor	IGFBP-3	367	3486	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of IGFBP-3 by the androgen_receptor in the lineage-related androgen-dependent LNCaP and androgen-independent C4-2 prostate_cancer models .
26305549	0	androgen_receptor	93,110	IL-8	88,92	androgen receptor	IL-8	367	3576	Gene	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	Tumor microenvironment B cells increase bladder_cancer metastasis via modulation of the IL-8 / androgen_receptor -LRB- AR -RRB- / MMPs signals .
19201527	0	androgen_receptor	98,115	Id-1	0,4	androgen receptor	Id-1	367	3397	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Id-1 expression in androgen-dependent prostate_cancer is negatively regulated by androgen through androgen_receptor .
17259348	0	androgen_receptor	55,72	IkappaB_kinase_epsilon	14,36	androgen receptor	IkappaB kinase epsilon	367	9641	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of IkappaB_kinase_epsilon expression by the androgen_receptor and the nuclear factor-kappaB transcription factor in prostate_cancer .
18819102	0	androgen_receptor	24,41	Interleukin-4	0,13	androgen receptor	Interleukin-4	367	3565	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-4 activates androgen_receptor through CBP/p300 .
11410519	0	androgen_receptor	96,113	Interleukin-6	0,13	androgen receptor	Interleukin-6	367	3569	Gene	Gene	expression|compound|START_ENTITY up-regulation|nmod|expression induces|nmod|up-regulation induces|nsubj|END_ENTITY	Interleukin-6 induces androgen responsiveness in prostate_cancer cells through up-regulation of androgen_receptor expression .
12431817	0	androgen_receptor	24,41	Interleukin-6	0,13	androgen receptor	Interleukin-6	367	3569	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Interleukin-6 regulates androgen_receptor activity and prostate_cancer cell growth .
12763015	0	androgen_receptor	39,56	Interleukin-6	0,13	androgen receptor	Interleukin-6	367	3569	Gene	Gene	transactivation|compound|START_ENTITY regulates|dobj|transactivation regulates|nsubj|END_ENTITY	Interleukin-6 differentially regulates androgen_receptor transactivation via PI3K-Akt , STAT3 , and MAPK , three distinct signal pathways in prostate_cancer cells .
17373716	0	androgen_receptor	133,150	Interleukin-6	0,13	androgen receptor	Interleukin-6	367	3569	Gene	Gene	activation|compound|START_ENTITY accompanied|nmod|activation stimulator|acl|accompanied associated|nmod|stimulator inhibitor|acl|associated undergoes|nmod|inhibitor undergoes|nsubj|END_ENTITY	Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen_receptor activation during LNCaP_prostate_cancer cell progression .
19011039	0	androgen_receptor	102,119	Interleukin-6	0,13	androgen receptor	Interleukin-6	367	3569	Gene	Gene	activation|nmod|START_ENTITY stimulation|nmod|activation stimulation|amod|END_ENTITY	Interleukin-6 stimulation of growth of prostate_cancer in vitro and in vivo through activation of the androgen_receptor .
9788616	0	androgen_receptor	110,127	Interleukin-6	0,13	androgen receptor	Interleukin-6	367	3569	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Interleukin-6 regulates prostate-specific protein expression in prostate_carcinoma cells by activation of the androgen_receptor .
17555712	0	androgen_receptor	14,31	JMJD2A	56,62	androgen receptor	JMJD2A	367	9682	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of androgen_receptor by histone demethylases JMJD2A and JMJD2D .
19022849	0	androgen_receptor	66,83	LRP16	32,37	androgen receptor	LRP16	367	28992	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	The single-macro domain protein LRP16 is an essential cofactor of androgen_receptor .
18212060	0	androgen_receptor	117,134	MAGE-11	74,81	androgen receptor	MAGE-11	367	4110	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen_receptor .
23893242	0	androgen_receptor	44,61	MST1	107,111	androgen receptor	MST1	367	4485	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Scaffold_attachment_factor_B1 regulates the androgen_receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2 .
15805247	0	androgen_receptor	39,56	Mammalian_target_of_rapamycin	60,89	androgen receptor	Mammalian target of rapamycin	367	2475	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Post-transcriptional regulation of the androgen_receptor by Mammalian_target_of_rapamycin .
24681825	0	androgen_receptor	78,95	NWD1	24,28	androgen receptor	NWD1	367	284434	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The NLR-related protein NWD1 is associated with prostate_cancer and modulates androgen_receptor signaling .
25175748	0	androgen_receptor	61,78	Nanog	24,29	androgen receptor	Nanog	367	79923	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	The pluripotency factor Nanog is directly upregulated by the androgen_receptor in prostate_cancer cells .
22761936	0	androgen_receptor	40,57	Nur77	24,29	androgen receptor	Nur77	11835(Tax:10090)	15370(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Orphan nuclear receptor Nur77 regulates androgen_receptor gene expression in mouse ovary .
11096094	0	androgen_receptor	36,53	Oct-1	0,5	androgen receptor	Oct-1	11835(Tax:10090)	20517(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Oct-1 preferentially interacts with androgen_receptor in a DNA-dependent manner that facilitates recruitment of SRC-1 .
21505150	0	androgen_receptor	46,63	Ornithine_decarboxylase	0,23	androgen receptor	Ornithine decarboxylase	11835(Tax:10090)	18263(Tax:10090)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Ornithine_decarboxylase is upregulated by the androgen_receptor in skeletal muscle and regulates myoblast proliferation .
10365100	0	androgen_receptor	21,38	P53	63,66	androgen receptor	P53	367	7157	Gene	Gene	gene|compound|START_ENTITY Amplification|nmod|gene associated|nsubjpass|Amplification associated|nmod|mutation mutation|nummod|END_ENTITY	Amplification of the androgen_receptor gene is associated with P53 mutation in hormone-refractory recurrent prostate_cancer .
10625666	0	androgen_receptor	88,105	PDEF	0,4	androgen receptor	PDEF	367	25803	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PDEF , a novel prostate epithelium-specific ets transcription factor , interacts with the androgen_receptor and activates prostate-specific_antigen gene expression .
22403175	0	androgen_receptor	58,75	PELP1	17,22	androgen receptor	PELP1	367	27043	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Central role for PELP1 in nonandrogenic activation of the androgen_receptor in prostate_cancer .
16914734	0	androgen_receptor	21,38	PIRH2	6,11	androgen receptor	PIRH2	367	25898	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Human PIRH2 enhances androgen_receptor signaling through inhibition of histone_deacetylase_1 and is overexpressed in prostate_cancer .
22495974	0	androgen_receptor	77,94	PITX2	39,44	androgen receptor	PITX2	367	5308	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Global methylation analysis identifies PITX2 as an upstream regulator of the androgen_receptor and IGF-I_receptor genes in prostate_cancer .
16140973	0	androgen_receptor	106,123	PSA	141,144	androgen receptor	PSA	367	354	Gene	Gene	occupancy|compound|START_ENTITY occupancy|nmod|locus locus|compound|END_ENTITY	Androgen_receptor-dependent PSA expression in androgen-independent prostate_cancer cells does not involve androgen_receptor occupancy of the PSA locus .
16140973	0	androgen_receptor	106,123	PSA	28,31	androgen receptor	PSA	367	354	Gene	Gene	occupancy|compound|START_ENTITY involve|dobj|occupancy involve|nsubj|expression expression|compound|END_ENTITY	Androgen_receptor-dependent PSA expression in androgen-independent prostate_cancer cells does not involve androgen_receptor occupancy of the PSA locus .
19575420	0	androgen_receptor	43,60	PSA	182,185	androgen receptor	PSA	367	354	Gene	Gene	expression|nmod|START_ENTITY lines|compound|expression lines|dep|implications implications|nmod|surrogacy surrogacy|compound|END_ENTITY	Docetaxel down-regulates the expression of androgen_receptor and prostate-specific_antigen but not prostate-specific_membrane_antigen in prostate_cancer cell lines : implications for PSA surrogacy .
21956655	0	androgen_receptor	14,31	PSA	0,3	androgen receptor	PSA	367	354	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PSA regulates androgen_receptor expression in prostate_cancer cells .
24820830	0	androgen_receptor	73,90	PSA	111,114	androgen receptor	PSA	367	354	Gene	Gene	genes|amod|START_ENTITY _|dobj|genes _|advcl|serum serum|dobj|levels levels|compound|END_ENTITY	Contribution of allelic variability in prostate_specific_antigen -LRB- PSA -RRB- _ androgen_receptor -LRB- AR -RRB- genes to serum PSA levels in men with prostate_cancer .
24820830	0	androgen_receptor	73,90	PSA	66,69	androgen receptor	PSA	367	354	Gene	Gene	genes|amod|START_ENTITY _|dobj|genes _|nsubj|Contribution Contribution|appos|END_ENTITY	Contribution of allelic variability in prostate_specific_antigen -LRB- PSA -RRB- _ androgen_receptor -LRB- AR -RRB- genes to serum PSA levels in men with prostate_cancer .
9044850	0	androgen_receptor	119,136	PSA	199,202	androgen receptor	PSA	367	354	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|gene gene|compound|END_ENTITY	Down-regulation of prostate-specific_antigen expression by finasteride through inhibition of complex formation between androgen_receptor and steroid_receptor-binding_consensus in the promoter of the PSA gene in LNCaP cells .
12914534	0	androgen_receptor	53,70	PTEN	4,8	androgen receptor	PTEN	367	5728	Gene	Gene	activity|compound|START_ENTITY modulator|nmod|activity modulator|nsubj|suppressor suppressor|compound|END_ENTITY	The PTEN tumor suppressor is a negative modulator of androgen_receptor transcriptional activity .
15205473	0	androgen_receptor	14,31	PTEN	45,49	androgen receptor	PTEN	367	5728	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of androgen_receptor signaling by PTEN -LRB- phosphatase and tensin homolog deleted on chromosome 10 -RRB- tumor suppressor through distinct mechanisms in prostate_cancer cells .
19074551	0	androgen_receptor	35,52	PTEN	15,19	androgen receptor	PTEN	367	5728	Gene	Gene	N|compound|START_ENTITY suppression|nmod|N suppression|compound|END_ENTITY	FoxO1 mediates PTEN suppression of androgen_receptor N - and C-terminal interactions and coactivator recruitment .
21532617	0	androgen_receptor	46,63	PTEN	27,31	androgen receptor	PTEN	367	5728	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of PTEN expression by androgen_receptor in prostate and breast_cancers .
22021428	0	androgen_receptor	71,88	PTEN	27,31	androgen receptor	PTEN	367	5728	Gene	Gene	translocation|nmod|START_ENTITY preventing|dobj|translocation regulates|nmod|preventing regulates|dobj|END_ENTITY	GATA2 negatively regulates PTEN by preventing nuclear translocation of androgen_receptor and by androgen-independent suppression of PTEN transcription in breast_cancer .
26285813	0	androgen_receptor	21,38	PTEN	47,51	androgen receptor	PTEN	11835(Tax:10090)	19211(Tax:10090)	Gene	Gene	actions|nmod|START_ENTITY promote|nsubj|actions promote|dobj|inactivation inactivation|compound|END_ENTITY	Androgen actions via androgen_receptor promote PTEN inactivation induced uterine cancer .
17909037	0	androgen_receptor	31,48	Peroxiredoxin_1	0,15	androgen receptor	Peroxiredoxin 1	367	5052	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Peroxiredoxin_1 interacts with androgen_receptor and enhances its transactivation .
21539911	0	androgen_receptor	66,83	Peroxiredoxin_2	0,15	androgen receptor	Peroxiredoxin 2	367	7001	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Peroxiredoxin_2 in the nucleus and cytoplasm distinctly regulates androgen_receptor activity in prostate_cancer cells .
19884383	0	androgen_receptor	87,104	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	0,67	androgen receptor	Peroxisome proliferator-activated receptor gamma coactivator-1alpha	367	10891	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha interacts with the androgen_receptor -LRB- AR -RRB- and promotes prostate_cancer cell growth by activating the AR .
12958311	0	androgen_receptor	45,62	RACK1	24,29	androgen receptor	RACK1	367	10399	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The scaffolding protein RACK1 interacts with androgen_receptor and promotes cross-talk through a protein_kinase_C signaling pathway .
17108144	0	androgen_receptor	108,125	RACK1	35,40	androgen receptor	RACK1	367	10399	Gene	Gene	phosphorylation|nmod|START_ENTITY regulate|dobj|phosphorylation regulate|nsubj|Receptor_for_activated_C_kinase_1 Receptor_for_activated_C_kinase_1|appos|END_ENTITY	Receptor_for_activated_C_kinase_1 -LRB- RACK1 -RRB- and Src regulate the tyrosine phosphorylation and function of the androgen_receptor .
14664718	0	androgen_receptor	86,103	RBaK	62,66	androgen receptor	RBaK	367	57786	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The retinoblastoma protein-associated transcription repressor RBaK interacts with the androgen_receptor and enhances its transcriptional activity .
10517667	0	androgen_receptor	43,60	RFG	0,3	androgen receptor	RFG	367	8031	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RFG -LRB- ARA70 , ELE1 -RRB- interacts with the human androgen_receptor in a ligand-dependent fashion , but functions only weakly as a coactivator in cotransfection assays .
20127734	0	androgen_receptor	14,31	Rheb	76,80	androgen receptor	Rheb	367	6009	Gene	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|nmod|END_ENTITY	Regulation of androgen_receptor transactivity and mTOR-S6 kinase pathway by Rheb in prostate_cancer cell proliferation .
18007036	0	androgen_receptor	24,41	SHP	75,78	androgen receptor	SHP	367	8431	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between the androgen_receptor and a segment of its corepressor SHP .
25199764	0	androgen_receptor	56,73	SMILE	0,5	androgen receptor	SMILE	367	58487	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	SMILE upregulated by metformin inhibits the function of androgen_receptor in prostate_cancer cells .
24174655	0	androgen_receptor	66,83	SMYD3	0,5	androgen receptor	SMYD3	367	64754	Gene	Gene	transcription|compound|START_ENTITY END_ENTITY|nmod|transcription	SMYD3 as an oncogenic driver in prostate_cancer by stimulation of androgen_receptor transcription .
17602621	0	androgen_receptor	53,70	SRC	76,79	androgen receptor	SRC	367	6714	Gene	Gene	association|nmod|START_ENTITY ligands|nmod|association activity|nmod|ligands activity|nmod|END_ENTITY	Nongenomic activity of ligands in the association of androgen_receptor with SRC .
16361251	0	androgen_receptor	16,33	SUMO-3	0,6	androgen receptor	SUMO-3	367	6612	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	SUMO-3 enhances androgen_receptor transcriptional activity through a sumoylation-independent mechanism in prostate_cancer cells .
23893242	0	androgen_receptor	44,61	Scaffold_attachment_factor_B1	0,29	androgen receptor	Scaffold attachment factor B1	367	6294	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Scaffold_attachment_factor_B1 regulates the androgen_receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2 .
24077602	0	androgen_receptor	57,74	Scaffold_attachment_factor_B1	0,29	androgen receptor	Scaffold attachment factor B1	367	6294	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|dep|inhibitor	Scaffold_attachment_factor_B1 : an intrinsic inhibitor of androgen_receptor downregulated in prostate_cancer .
19277043	0	androgen_receptor	63,80	Secreted_Frizzled-related_protein-1	0,35	androgen receptor	Secreted Frizzled-related protein-1	367	6422	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	Secreted_Frizzled-related_protein-1 is a negative regulator of androgen_receptor activity in prostate_cancer .
17505061	0	androgen_receptor	108,125	Sirtuin_1	0,9	androgen receptor	Sirtuin 1	367	23411	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Sirtuin_1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen_receptor .
23566155	0	androgen_receptor	46,63	Ski-interacting_protein	0,23	androgen receptor	Ski-interacting protein	367	22938	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ski-interacting_protein -LRB- SKIP -RRB- interacts with androgen_receptor in the nucleus and modulates androgen-dependent transcription .
24347472	0	androgen_receptor	15,32	Skp2	0,4	androgen receptor	Skp2	367	6502	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Skp2 regulates androgen_receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate_cancer .
26939395	0	androgen_receptor	72,89	Skp2	22,26	androgen receptor	Skp2	367	6502	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Regulatory effect of Skp2 on the expression and transactivation of the androgen_receptor in the progression of castration-resistant_prostate_cancer -RSB- .
15661808	0	androgen_receptor	87,104	Sp1	36,39	androgen receptor	Sp1	367	6667	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen_receptor in human prostate_cancer cells .
18430409	0	androgen_receptor	59,76	Sp1	96,99	androgen receptor	Sp1	367	6667	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	Inhibitory effect of acetyl-11-keto-beta-boswellic_acid on androgen_receptor by interference of Sp1 binding activity in prostate_cancer cells .
20148354	0	androgen_receptor	19,36	Sp1	99,102	androgen receptor	Sp1	367	6667	Gene	Gene	Suppression|nmod|START_ENTITY function|nsubj|Suppression function|nmod|interactions interactions|nmod|END_ENTITY	Suppression of the androgen_receptor function by quercetin through protein-protein interactions of Sp1 , c-Jun , and the androgen_receptor in human prostate_cancer cells .
8994183	0	androgen_receptor	87,104	Sp1	136,139	androgen receptor	Sp1	367	6667	Gene	Gene	promoter|compound|START_ENTITY domain|nmod|promoter role|nmod|domain role|acl|interacting interacting|nmod|END_ENTITY	Functional role of a conformationally flexible homopurine/homopyrimidine domain of the androgen_receptor gene promoter interacting with Sp1 and a pyrimidine single strand DNA-binding protein .
17079466	0	androgen_receptor	32,49	Src	85,88	androgen receptor	Src	367	6714	Gene	Gene	activation|nmod|START_ENTITY activation|dep|involvement involvement|nmod|pathway pathway|compound|END_ENTITY	Inappropriate activation of the androgen_receptor by nonsteroids : involvement of the Src kinase pathway and its therapeutic implications .
17486077	0	androgen_receptor	60,77	Src	49,52	androgen receptor	Src	367	6714	Gene	Gene	domain-mediated|nmod|START_ENTITY domain-mediated|dobj|binding binding|nmod|END_ENTITY	Inhibition of the SH3 domain-mediated binding of Src to the androgen_receptor and its effect on tumor growth .
18223692	0	androgen_receptor	23,40	Src	0,3	androgen receptor	Src	11835(Tax:10090)	20779(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|potentiates potentiates|compound|END_ENTITY	Src kinase potentiates androgen_receptor transactivation function and invasion of androgen-independent prostate_cancer C4-2 cells .
24130806	0	androgen_receptor	10,27	Src	28,31	androgen receptor	Src	367	6714	Gene	Gene	START_ENTITY|parataxis|impairs impairs|nsubj|complex complex|compound|END_ENTITY	Targeting androgen_receptor / Src complex impairs the aggressive phenotype of human fibrosarcoma cells .
18172316	0	androgen_receptor	43,60	Stat5	21,26	androgen receptor	Stat5	367	6776	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Transcription factor Stat5 synergizes with androgen_receptor in prostate_cancer cells .
21216933	0	androgen_receptor	46,63	Stat5	21,26	androgen receptor	Stat5	367	6776	Gene	Gene	degradation|compound|START_ENTITY enhances|dobj|degradation enhances|nsubj|knockdown knockdown|compound|END_ENTITY	Transcription factor Stat5 knockdown enhances androgen_receptor degradation and delays castration-resistant prostate_cancer progression in vivo .
11792840	0	androgen_receptor	28,45	Supervillin	0,11	androgen receptor	Supervillin	367	6840	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Supervillin associates with androgen_receptor and modulates its transcriptional activity .
19325002	0	androgen_receptor	101,118	TBP-1	23,28	androgen receptor	TBP-1	367	5702	Gene	Gene	function|compound|START_ENTITY enhances|dobj|function enhances|nsubj|Tat-binding_protein-1 Tat-binding_protein-1|appos|END_ENTITY	Tat-binding_protein-1 -LRB- TBP-1 -RRB- , an ATPase of 19S regulatory particles of the 26S proteasome , enhances androgen_receptor function in cooperation with TBP-1-interacting_protein / Hop2 .
18651839	0	androgen_receptor	56,73	TGF-beta1	34,43	androgen receptor	TGF-beta1	367	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional regulation of the TGF-beta1 promoter by androgen_receptor .
15090305	0	androgen_receptor	41,58	THP-1	88,93	androgen receptor	THP-1	367	2736	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of testosterone on expression of androgen_receptor in human monocytic cell line THP-1 -RSB- .
21656834	0	androgen_receptor	24,41	TM4SF1	0,6	androgen receptor	TM4SF1	367	4071	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	TM4SF1 , a novel primary androgen_receptor target gene over-expressed in human prostate_cancer and involved in cell migration .
12949936	0	androgen_receptor	56,73	TR2	0,3	androgen receptor	TR2	367	7181	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	TR2 orphan receptor functions as negative modulator for androgen_receptor in prostate_cancer cells PC-3 .
19909775	0	androgen_receptor	47,64	TRIM24	0,6	androgen receptor	TRIM24	367	8805	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TRIM24 mediates ligand-dependent activation of androgen_receptor and is repressed by a bromodomain-containing protein , BRD7 , in prostate_cancer cells .
23634227	0	androgen_receptor	19,36	Tzfp	0,4	androgen receptor	Tzfp	11835(Tax:10090)	58206(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Tzfp represses the androgen_receptor in mouse testis .
20501646	0	androgen_receptor	52,69	USP26	28,33	androgen receptor	USP26	367	83844	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The deubiquitinating enzyme USP26 is a regulator of androgen_receptor signaling .
10383460	0	androgen_receptor	24,41	Ubc9	0,4	androgen receptor	Ubc9	367	7329	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ubc9 interacts with the androgen_receptor and activates receptor-dependent transcription .
23863405	0	androgen_receptor	45,62	Ube2b	18,23	androgen receptor	Ube2b	11835(Tax:10090)	22210(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Ube2b as a novel target of androgen_receptor in mouse sertoli cells .
24056413	0	androgen_receptor	61,78	Usp12	24,29	androgen receptor	Usp12	367	9099	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen_receptor .
20650881	0	androgen_receptor	55,72	Utp14b	99,105	androgen receptor	Utp14b	11835(Tax:10090)	195434(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Gene expression alterations by conditional knockout of androgen_receptor in adult sertoli cells of Utp14b -LRB- jsd/jsd -RRB- -LRB- jsd -RRB- mice .
21312389	0	androgen_receptor	55,72	Utp14b	99,105	androgen receptor	Utp14b	11835(Tax:10090)	195434(Tax:10090)	Gene	Gene	knockout|nmod|START_ENTITY alterations|nmod|knockout alterations|nmod|cells cells|nmod|mice mice|amod|jsd/jsd jsd/jsd|advmod|END_ENTITY	Gene expression alterations by conditional knockout of androgen_receptor in adult Sertoli cells of Utp14b jsd/jsd -LRB- jsd -RRB- mice .
19668226	0	androgen_receptor	53,70	Yin_Yang_1	0,10	androgen receptor	Yin Yang 1	367	7528	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Yin_Yang_1 regulates the transcriptional activity of androgen_receptor .
22391641	0	androgen_receptor	87,104	ZEB1	72,76	androgen receptor	ZEB1	367	6935	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Androgen_receptor is overexpressed in boys with severe hypospadias , and ZEB1 regulates androgen_receptor expression in human foreskin cells .
25160502	0	androgen_receptor	16,33	ZEB1	53,57	androgen receptor	ZEB1	367	6935	Gene	Gene	elements|compound|START_ENTITY presence|nmod|elements regulates|nsubj|presence regulates|dobj|expression expression|nummod|END_ENTITY	The presence of androgen_receptor elements regulates ZEB1 expression in the absence of androgen_receptor .
25160502	0	androgen_receptor	87,104	ZEB1	53,57	androgen receptor	ZEB1	367	6935	Gene	Gene	absence|nmod|START_ENTITY expression|nmod|absence expression|nummod|END_ENTITY	The presence of androgen_receptor elements regulates ZEB1 expression in the absence of androgen_receptor .
21949845	0	androgen_receptor	58,75	ZMIZ1	0,5	androgen receptor	ZMIZ1	367	57178	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	ZMIZ1 preferably enhances the transcriptional activity of androgen_receptor with short polyglutamine tract .
19052375	0	androgen_receptor	146,163	androgen_receptor	60,77	androgen receptor	androgen receptor	367	367	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Crystallization and preliminary X-ray analysis of the human androgen_receptor ligand-binding domain with a coactivator-like peptide and selective androgen_receptor modulators .
19052375	0	androgen_receptor	60,77	androgen_receptor	146,163	androgen receptor	androgen receptor	367	367	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Crystallization and preliminary X-ray analysis of the human androgen_receptor ligand-binding domain with a coactivator-like peptide and selective androgen_receptor modulators .
21541973	0	androgen_receptor	14,31	angiotensin_II_type_1_receptor	51,81	androgen receptor	angiotensin II type 1 receptor	11835(Tax:10090)	11610(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of androgen_receptor expression through angiotensin_II_type_1_receptor in prostate_cancer cells .
25908644	0	androgen_receptor	108,125	arylhydrocarbon-receptor	70,94	androgen receptor	arylhydrocarbon-receptor	367	196	Gene	Gene	using|nmod|START_ENTITY using|dobj|END_ENTITY	A novel prostate_cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen_receptor and its splice variants .
11856748	0	androgen_receptor	4,21	beta-catenin	34,46	androgen receptor	beta-catenin	367	1499	Gene	Gene	promote|nsubj|START_ENTITY promote|dobj|translocation translocation|amod|END_ENTITY	The androgen_receptor can promote beta-catenin nuclear translocation independently of adenomatous_polyposis_coli .
11916967	0	androgen_receptor	9,26	beta-catenin	44,56	androgen receptor	beta-catenin	367	1499	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Liganded androgen_receptor interaction with beta-catenin : nuclear co-localization and modulation of transcriptional activity in neuronal cells .
12944908	0	androgen_receptor	52,69	beta-catenin	100,112	androgen receptor	beta-catenin	367	1499	Gene	Gene	factor|compound|START_ENTITY factor|nmod|END_ENTITY	Functional localization and competition between the androgen_receptor and T-cell factor for nuclear beta-catenin : a means for inhibition of the Tcf signaling axis .
16141201	0	androgen_receptor	80,97	beta-catenin	15,27	androgen receptor	beta-catenin	367	1499	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of beta-catenin and TIF2/GRIP1 in transcriptional activation by the androgen_receptor .
16210377	0	androgen_receptor	91,108	beta-catenin	122,134	androgen receptor	beta-catenin	11835(Tax:10090)	12387(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	Testosterone inhibits adipogenic differentiation in 3T3-L1 cells : nuclear translocation of androgen_receptor complex with beta-catenin and T-cell_factor_4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors .
17653089	0	androgen_receptor	28,45	beta-catenin	61,73	androgen receptor	beta-catenin	367	1499	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|pathway pathway|amod|END_ENTITY	Inappropriate activation of androgen_receptor by relaxin via beta-catenin pathway .
18948405	0	androgen_receptor	72,89	beta-catenin	91,103	androgen receptor	beta-catenin	11835(Tax:10090)	12387(Tax:10090)	Gene	Gene	talk|nmod|START_ENTITY Regulation|dep|talk Regulation|parataxis|signaling signaling|nsubj|factor-beta factor-beta|compound|END_ENTITY	Regulation of myogenic differentiation by androgens : cross talk between androgen_receptor / beta-catenin and follistatin/transforming growth factor-beta signaling pathways .
19095249	0	androgen_receptor	23,40	c-FLIP	53,59	androgen receptor	c-FLIP	367	8837	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	Stromal anti-apoptotic androgen_receptor target gene c-FLIP in prostate_cancer .
9591784	0	androgen_receptor	45,62	c-Jun	29,34	androgen receptor	c-Jun	367	3725	Gene	Gene	transactivation|compound|START_ENTITY transactivation|amod|END_ENTITY	Identification of domains of c-Jun mediating androgen_receptor transactivation .
17283128	0	androgen_receptor	4,21	c-Met	61,66	androgen receptor	c-Met	367	4233	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The androgen_receptor negatively regulates the expression of c-Met : implications for a novel mechanism of prostate_cancer progression .
17011549	0	androgen_receptor	132,149	c-Rel	99,104	androgen receptor	c-Rel	367	5966	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Unraveling androgen_receptor interactomes by an array-based method : discovery of proto-oncoprotein c-Rel as a negative regulator of androgen_receptor .
11719263	0	androgen_receptor	53,70	c_oxidase_subunit_Vb	11,31	androgen receptor	c oxidase subunit Vb	367	1329	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Cytochrome c_oxidase_subunit_Vb interacts with human androgen_receptor : a potential mechanism for neurotoxicity in spinobulbar muscular atrophy .
14695896	0	androgen_receptor	39,56	calmodulin	62,72	androgen receptor	calmodulin	367	808	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of androgen_receptor with calmodulin in prostate_cancer cells .
19150386	0	androgen_receptor	32,49	calreticulin	68,80	androgen receptor	calreticulin	367	811	Gene	Gene	localization|nmod|START_ENTITY independent|nsubj|localization independent|nmod|END_ENTITY	Cytoplasmic localization of the androgen_receptor is independent of calreticulin .
24055403	0	androgen_receptor	12,29	cannabinoid_receptor_type_1	63,90	androgen receptor	cannabinoid receptor type 1	24208(Tax:10116)	25248(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|amod|END_ENTITY	The role of androgen_receptor in transcriptional modulation of cannabinoid_receptor_type_1 gene in rat trigeminal_ganglia .
23229005	0	androgen_receptor	18,35	connexin_43	104,115	androgen receptor	connexin 43	11835(Tax:10090)	14609(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Expression of the androgen_receptor in the testis of mice with a Sertoli cell specific knock-out of the connexin_43 gene -LRB- SCCx43KO -LRB- - / - -RRB- -RRB- .
12941814	0	androgen_receptor	29,46	cyclin_D1	15,24	androgen receptor	cyclin D1	367	595	Gene	Gene	regulation|compound|START_ENTITY Specificity|nmod|regulation Specificity|nmod|END_ENTITY	Specificity of cyclin_D1 for androgen_receptor regulation .
20421209	0	androgen_receptor	38,55	cyclin_D1	14,23	androgen receptor	cyclin D1	367	595	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of cyclin_D1 expression by androgen_receptor in breast_cancer cells -- identification of a novel androgen response element .
8912815	0	androgen_receptor	14,31	epidermal_growth_factor	35,58	androgen receptor	epidermal growth factor	11835(Tax:10090)	13645(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|modulation modulation|compound|END_ENTITY	Activation of androgen_receptor in epidermal_growth_factor modulation of fetal mouse sexual differentiation .
15288768	0	androgen_receptor	4,21	epidermal_growth_factor_receptor	42,74	androgen receptor	epidermal growth factor receptor	367	1956	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	The androgen_receptor associates with the epidermal_growth_factor_receptor in androgen-sensitive_prostate_cancer cells .
17205307	0	androgen_receptor	14,31	estrogen_receptor-alpha	61,84	androgen receptor	estrogen receptor-alpha	443042(Tax:9940)	443228(Tax:9940)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of androgen_receptor and its co-localization with estrogen_receptor-alpha in the developing pituitary gland of sheep fetus .
21359179	0	androgen_receptor	41,58	filamin_A	59,68	androgen receptor	filamin A	367	2316	Gene	Gene	association|compound|START_ENTITY association|compound|END_ENTITY	Androgen-induced cell migration : role of androgen_receptor / filamin_A association .
25138562	0	androgen_receptor	76,93	glucocorticoid_receptor	18,41	androgen receptor	glucocorticoid receptor	367	2908	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	The expression of glucocorticoid_receptor is negatively regulated by active androgen_receptor signaling in prostate_tumors .
16033069	0	androgen_receptor	23,40	hAR	42,45	androgen receptor	hAR	367	10894	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of human androgen_receptor -LRB- hAR -RRB- gene in prostate_cancer cell lines PC-EW and PC-OR .
21242980	0	androgen_receptor	14,31	histone_deacetylase_4	44,65	androgen receptor	histone deacetylase 4	367	9759	Gene	Gene	activity|compound|START_ENTITY Inhibition|nmod|activity Inhibition|nmod|END_ENTITY	Inhibition of androgen_receptor activity by histone_deacetylase_4 through receptor SUMOylation .
11751884	0	androgen_receptor	18,35	interleukin-6	57,70	androgen receptor	interleukin-6	367	3569	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Activation of the androgen_receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways .
24994782	0	androgen_receptor	74,91	keratin_33B	23,34	androgen receptor	keratin 33B	24208(Tax:10116)	450227(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Testosterone regulates keratin_33B expression in rat penis growth through androgen_receptor signaling .
22128178	0	androgen_receptor	27,44	let-7c	9,15	androgen receptor	let-7c	367	406885	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	MicroRNA let-7c suppresses androgen_receptor expression and activity via regulation of Myc expression in prostate_cancer cells .
22314666	0	androgen_receptor	18,35	miR-141	0,7	androgen receptor	miR-141	367	406933	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	miR-141 modulates androgen_receptor transcriptional activity in human prostate_cancer cells through targeting the small_heterodimer_partner protein .
25969144	0	androgen_receptor	21,38	miR-145	0,7	androgen receptor	miR-145	367	406937	Gene	Gene	suppress|dobj|START_ENTITY suppress|nsubj|END_ENTITY	miR-145 suppress the androgen_receptor in prostate_cancer cells and correlates to prostate_cancer prognosis .
25969144	0	androgen_receptor	21,38	miR-145	0,7	androgen receptor	miR-145	367	406937	Gene	Gene	suppress|dobj|START_ENTITY suppress|nsubj|END_ENTITY	miR-145 suppress the androgen_receptor in prostate_cancer cells and correlates to prostate_cancer prognosis .
23571738	0	androgen_receptor	33,50	miR-205	0,7	androgen receptor	miR-205	367	406988	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	miR-205 negatively regulates the androgen_receptor and is associated with adverse outcome of prostate_cancer patients .
12089345	0	androgen_receptor	48,65	nuclear_receptor_corepressor	69,97	androgen receptor	nuclear receptor corepressor	367	9611	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the dihydrotestosterone-activated androgen_receptor by nuclear_receptor_corepressor .
19151763	0	androgen_receptor	65,82	p38	19,22	androgen receptor	p38	367	1432	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen_receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate_cancer .
23009195	0	androgen_receptor	22,39	p450c17	71,78	androgen receptor	p450c17	367	1586	Gene	Gene	proteins|compound|START_ENTITY proteins|nummod|END_ENTITY	Immunoreactivities of androgen_receptor , estrogen receptors , p450arom , p450c17 proteins in wild ground squirrels ovaries during the nonbreeding and breeding seasons .
20388792	0	androgen_receptor	27,44	p52	59,62	androgen receptor	p52	367	4791	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Aberrant activation of the androgen_receptor by NF-kappaB2 / p52 in prostate_cancer cells .
18084622	0	androgen_receptor	14,31	p53	59,62	androgen receptor	p53	367	7157	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of androgen_receptor is negatively regulated by p53 .
18945670	0	androgen_receptor	8,25	p53	128,131	androgen receptor	p53	367	7157	Gene	Gene	Loss|nmod|START_ENTITY stress|nsubj|Loss stress|nmod|dynamics dynamics|nmod|END_ENTITY	Loss of androgen_receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly -LRB- ADP-ribose -RRB- polymerase PARP-1 .
21997969	0	androgen_receptor	46,63	p53	14,17	androgen receptor	p53	367	7157	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Activation of p53 signaling and inhibition of androgen_receptor mediate tanshinone_IIA induced G1_arrest in LNCaP_prostate_cancer cells .
22383394	0	androgen_receptor	82,99	p53	14,17	androgen receptor	p53	367	7157	Gene	Gene	chromatin|nmod|START_ENTITY specificity|nmod|chromatin modifies|dobj|specificity modifies|nsubj|Inhibition Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen_receptor .
23359208	0	androgen_receptor	109,126	p53	145,148	androgen receptor	p53	367	7157	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Anacardic_acid -LRB- 6-pentadecylsalicylic_acid -RRB- induces apoptosis of prostate_cancer cells through inhibition of androgen_receptor and activation of p53 signaling .
23403291	0	androgen_receptor	66,83	p53	84,87	androgen receptor	p53	367	7157	Gene	Gene	controlled|nmod|START_ENTITY sebaceous|acl:relcl|controlled sebaceous|parataxis|axis axis|nsubj|END_ENTITY	c-MYC-induced sebaceous gland differentiation is controlled by an androgen_receptor / p53 axis .
9735408	0	androgen_receptor	135,152	p53	87,90	androgen receptor	p53	367	7157	Gene	Gene	gene|compound|START_ENTITY analysis|nmod|gene analysis|compound|END_ENTITY	Efficacious diagnosis of primary and metastatic human carcinomas with a combination of p53 mutation analysis and clonality analysis of androgen_receptor gene .
11226426	0	androgen_receptor	85,102	parathyroid_hormone	57,76	androgen receptor	parathyroid hormone	11835(Tax:10090)	19226(Tax:10090)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Testosterone inhibits osteoclast formation stimulated by parathyroid_hormone through androgen_receptor .
16373395	0	androgen_receptor	177,194	silencing_mediator_of_retinoid_and_thyroid_hormone_receptor	17,76	androgen receptor	silencing mediator of retinoid and thyroid hormone receptor	367	9612	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The corepressors silencing_mediator_of_retinoid_and_thyroid_hormone_receptor and nuclear receptor corepressor are involved in agonist - and antagonist-regulated transcription by androgen_receptor .
16356647	0	androgen_receptor	79,96	tyrosine_hydroxylase	50,70	androgen receptor	tyrosine hydroxylase	367	7054	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of the transcriptional activity of the tyrosine_hydroxylase gene by androgen_receptor .
16278385	0	androgen_receptor	4,21	vascular_endothelial_growth_factor	55,89	androgen receptor	vascular endothelial growth factor	367	7422	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The androgen_receptor is significantly associated with vascular_endothelial_growth_factor and hypoxia sensing via hypoxia-inducible factors HIF-1a , HIF-2a , and the prolyl hydroxylases in human prostate_cancer .
23564791	0	angio-associated_migratory_cell_protein	14,53	AAMP	55,59	angio-associated migratory cell protein	AAMP	14	14	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	The impact of angio-associated_migratory_cell_protein -LRB- AAMP -RRB- on breast_cancer cells in vitro and its clinical significance .
19931242	0	angiocidin	19,29	tissue_transglutaminase	35,58	angiocidin	tissue transglutaminase	5710	7052	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of angiocidin with tissue_transglutaminase .
11299848	0	angiogenin	16,26	ANG	28,31	angiogenin	ANG	283	283	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of angiogenin -LRB- ANG -RRB- in invasive_cervical_cancer and in cervical_intraepithelial_neoplasia -LRB- CIN -RRB- .
17462671	0	angiogenin	57,67	ANG	69,72	angiogenin	ANG	283	283	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variations in the coding and regulatory sequences of the angiogenin -LRB- ANG -RRB- gene are not associated to ALS -LRB- amyotrophic_lateral_sclerosis -RRB- in the Italian population .
11400113	0	angiomodulin	14,26	mac25	58,63	angiomodulin	mac25	3490	3490	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of angiomodulin -LRB- tumor-derived_adhesion_factor / mac25 -RRB- in invading tumor cells correlates with poor prognosis in human colorectal_cancer .
21685940	0	angiomotin-like-1	18,35	YAP	86,89	angiomotin-like-1	YAP	154810	10413	Gene	Gene	roles|acl|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of angiomotin-like-1 and zona_occludens-2 on pro-apoptotic function of YAP .
15013125	0	angiopoietin	43,55	tie-2	65,70	angiopoietin	tie-2	284	7010	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Plasma angiopoietin-1 , angiopoietin-2 , and angiopoietin receptor tie-2 levels in congestive_heart_failure .
15126358	0	angiopoietin-1	28,42	Interleukin-1beta	0,17	angiopoietin-1	Interleukin-1beta	284	3553	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells .
11755466	0	angiopoietin-1	14,28	TEK	46,49	angiopoietin-1	TEK	284	7010	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of angiopoietin-1 and its receptor TEK in hematopoietic cells from patients with myeloid_leukemia .
15694363	0	angiopoietin-1	20,34	TNF-alpha	0,9	angiopoietin-1	TNF-alpha	284	7124	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	TNF-alpha modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-kappa_B signalling pathway .
11246533	0	angiopoietin-1	32,46	Thrombin	0,8	angiopoietin-1	Thrombin	284	2147	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Thrombin induces the release of angiopoietin-1 from platelets .
26463042	0	angiopoietin-1	46,60	Tie-2	80,85	angiopoietin-1	Tie-2	284	7010	Gene	Gene	ratios|dep|START_ENTITY ratios|compound|END_ENTITY	Prognostic significance of the angiopoietin-2 / angiopoietin-1 and angiopoietin-1 / Tie-2 ratios for early_sepsis in an emergency_department .
19424712	0	angiopoietin-1	67,81	Tie2	13,17	angiopoietin-1	Tie2	284	7010	Gene	Gene	localizes|nmod|START_ENTITY localizes|nsubj|END_ENTITY	Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1 .
14601137	0	angiopoietin-1	22,36	VEGF	49,53	angiopoietin-1	VEGF	100342781(Tax:9986)	100008899(Tax:9986)	Gene	Gene	START_ENTITY|acl|followed followed|nmod|END_ENTITY	Pre-administration of angiopoietin-1 followed by VEGF induces functional and mature vascular formation in a rabbit ischemic model .
15302795	0	angiopoietin-1	7,21	angiopoietin-2	23,37	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	Plasma|nummod|START_ENTITY Plasma|nummod|END_ENTITY	Plasma angiopoietin-1 , angiopoietin-2 , angiopoietin receptor tie-2 , and vascular_endothelial_growth_factor levels in acute_coronary_syndromes .
17451406	0	angiopoietin-1	94,108	angiopoietin-2	112,126	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	START_ENTITY|nmod|correlate correlate|amod|END_ENTITY	Serum concentrations of angiogenic cytokines in Waldenstrom_macroglobulinaemia : the ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity .
18182823	0	angiopoietin-1	16,30	angiopoietin-2	65,79	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	Balance|acl|START_ENTITY favor|nsubj|Balance favor|nmod|END_ENTITY	Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic_plaques with high microvessel density .
18287135	0	angiopoietin-1	27,41	angiopoietin-2	45,59	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib .
22642477	0	angiopoietin-1	76,90	angiopoietin-2	61,75	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|dep|ratio	Dynamic changes in serum angiopoietin-1 , angiopoietin-2 , and angiopoietin-2 / angiopoietin-1 ratio in acute_myocardial_infarction patients treated with primary percutaneous coronary intervention .
23915833	0	angiopoietin-1	22,36	angiopoietin-2	7,21	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	ratio|amod|START_ENTITY associated|nsubjpass|ratio END_ENTITY|parataxis|associated	A high angiopoietin-2 / angiopoietin-1 ratio is associated with a high risk of septic_shock in patients with febrile_neutropenia .
25161936	0	angiopoietin-1	43,57	angiopoietin-2	59,73	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	ratio|amod|START_ENTITY ratio|amod|END_ENTITY	Effects of laser photocoagulation on serum angiopoietin-1 , angiopoietin-2 , angiopoietin-1 / angiopoietin-2 ratio , and soluble angiopoietin receptor Tie-2 levels in type 2 diabetic patients with proliferative_diabetic_retinopathy .
26463042	0	angiopoietin-1	46,60	angiopoietin-2	31,45	angiopoietin-1	angiopoietin-2	284	285	Gene	Gene	ratios|dep|START_ENTITY ratios|amod|END_ENTITY	Prognostic significance of the angiopoietin-2 / angiopoietin-1 and angiopoietin-1 / Tie-2 ratios for early_sepsis in an emergency_department .
15637314	0	angiopoietin-1	20,34	estrogen_receptor-alpha	59,82	angiopoietin-1	estrogen receptor-alpha	11600(Tax:10090)	13982(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Estradiol regulates angiopoietin-1 mRNA expression through estrogen_receptor-alpha in a rodent experimental stroke model .
24642125	0	angiopoietin-1	100,114	hnRNP-K	24,31	angiopoietin-1	hnRNP-K	284	3190	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling_protein-2 by angiopoietin-1 .
11334054	0	angiopoietin-1	88,102	tie2	117,121	angiopoietin-1	tie2	11600(Tax:10090)	21687(Tax:10090)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	The 3T3-L1 fibroblast to adipocyte conversion is accompanied by increased expression of angiopoietin-1 , a ligand for tie2 .
11943723	0	angiopoietin-1	35,49	tie2	18,22	angiopoietin-1	tie2	284	7010	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs_squamous_cell_carcinoma growth .
17466926	0	angiopoietin-1	14,28	tumor_necrosis_factor-alpha	66,93	angiopoietin-1	tumor necrosis factor-alpha	284	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of angiopoietin-1 in osteoblasts and its inhibition by tumor_necrosis_factor-alpha and interferon-gamma .
17287278	0	angiopoietin-2	74,88	AP-1	104,108	angiopoietin-2	AP-1	285	3725	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus promotes angiogenesis by inducing angiopoietin-2 expression via AP-1 and Ets1 .
11002428	2	angiopoietin-2	284,298	Ang2	300,304	angiopoietin-1	Ang1	284	284	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	High levels of angiopoietin-2 -LRB- Ang2 -RRB- mRNA are observed in vascular activation during tumorigenesis .
16723371	0	angiopoietin-2	16,30	Angiopoietin-1	0,14	angiopoietin-2	Angiopoietin-1	285	284	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Angiopoietin-1 , angiopoietin-2 and Tie-2 expression in eutopic endometrium in advanced endometriosis .
19478794	0	angiopoietin-2	15,29	Angiopoietin-1	0,14	angiopoietin-2	Angiopoietin-1	285	284	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|dep|ratio	Angiopoietin-1 / angiopoietin-2 ratio for prediction of preeclampsia .
21113176	0	angiopoietin-2	72,86	Angiopoietin-1	0,14	angiopoietin-2	Angiopoietin-1	11601(Tax:10090)	11600(Tax:10090)	Gene	Gene	glucose_condition|amod|START_ENTITY blunted|nmod|glucose_condition function|acl|blunted protects|dobj|function protects|nsubj|END_ENTITY	Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose_condition .
22505659	0	angiopoietin-2	70,84	Angiopoietin-1	0,14	angiopoietin-2	Angiopoietin-1	11601(Tax:10090)	11600(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY inhibition|nmod|release mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells .
16290311	0	angiopoietin-2	13,27	COX-2	47,52	angiopoietin-2	COX-2	285	4513	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of angiopoietin-2 gene expression by COX-2 : a novel role for COX-2 inhibitors during hepatocarcinogenesis .
11152449	0	angiopoietin-2	15,29	Leptin	0,6	angiopoietin-2	Leptin	89805(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin induces angiopoietin-2 expression in adipose tissues .
11861279	0	angiopoietin-2	55,69	Thrombin	0,8	angiopoietin-2	Thrombin	285	2147	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells .
17513791	0	angiopoietin-2	62,76	Tie-2	14,19	angiopoietin-2	Tie-2	285	7010	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Tie-2 by human monocytes and their responses to angiopoietin-2 .
26463042	0	angiopoietin-2	31,45	Tie-2	80,85	angiopoietin-2	Tie-2	285	7010	Gene	Gene	ratios|amod|START_ENTITY ratios|compound|END_ENTITY	Prognostic significance of the angiopoietin-2 / angiopoietin-1 and angiopoietin-1 / Tie-2 ratios for early_sepsis in an emergency_department .
11166279	0	angiopoietin-2	21,35	Tie2	110,114	angiopoietin-2	Tie2	285	7010	Gene	Gene	model|amod|START_ENTITY action|nmod|model associated|nsubjpass|action associated|nmod|activation activation|nmod|END_ENTITY	Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2 .
11733376	0	angiopoietin-2	81,95	Tie2	10,14	angiopoietin-2	Tie2	285	7010	Gene	Gene	expression|amod|START_ENTITY response|nmod|expression response|compound|END_ENTITY	Increased Tie2 expression , enhanced response to angiopoietin-1 , and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells .
15893672	0	angiopoietin-2	17,31	Tie2	99,103	angiopoietin-2	Tie2	285	7010	Gene	Gene	domain|amod|START_ENTITY Structure|nmod|domain involved|nsubj|Structure involved|nmod|recognition recognition|amod|END_ENTITY	Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition .
19339208	0	angiopoietin-2	11,25	Tie2	76,80	angiopoietin-2	Tie2	285	7010	Gene	Gene	variant|amod|START_ENTITY activates|nsubj|variant activates|dobj|receptor receptor|amod|END_ENTITY	A designed angiopoietin-2 variant , pentameric COMP-Ang2 , strongly activates Tie2 receptor and stimulates angiogenesis .
22342979	0	angiopoietin-2	42,56	Tie2	19,23	angiopoietin-2	Tie2	285	7010	Gene	Gene	cells|amod|START_ENTITY role|nmod|cells role|amod|END_ENTITY	Tie1 regulates the Tie2 agonistic role of angiopoietin-2 in human lymphatic endothelial cells .
10403795	0	angiopoietin-2	36,50	VEGF	78,82	angiopoietin-2	VEGF	395610(Tax:9031)	395909(Tax:9031)	Gene	Gene	Ang-2B|amod|START_ENTITY Characterization|nmod|Ang-2B Characterization|nmod|development development|amod|END_ENTITY	Characterization of a novel form of angiopoietin-2 -LRB- Ang-2B -RRB- and expression of VEGF and angiopoietin-2 during chicken testicular development and regression .
21269615	0	angiopoietin-2	50,64	VEGF	44,48	angiopoietin-2	VEGF	285	7422	Gene	Gene	agonist|amod|START_ENTITY agonist|nmod|END_ENTITY	Effect of GnRH agonist and hCG treatment on VEGF , angiopoietin-2 , and VE-cadherin : trying to explain the link to ovarian_hyperstimulation_syndrome .
24928471	0	angiopoietin-2	6,20	VEGF	33,37	angiopoietin-2	VEGF	285	7422	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute_dengue_virus_infection .
25088418	0	angiopoietin-2	8,22	VEGF	55,59	angiopoietin-2	VEGF	285	7422	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	Role of angiopoietin-2 in adaptive_tumor resistance to VEGF signaling blockade .
25459946	0	angiopoietin-2	43,57	VEGF	149,153	angiopoietin-2	VEGF	285	7422	Gene	Gene	determination|amod|START_ENTITY free|dobj|determination free|nmod|therapy therapy|nmod|CrossMab CrossMab|compound|END_ENTITY	An immunodepletion procedure advances free angiopoietin-2 determination in human plasma samples during anti-cancer therapy with bispecific anti-Ang2 / VEGF CrossMab .
25245329	0	angiopoietin-2	6,20	VEGFR-2	33,40	angiopoietin-2	VEGFR-2	285	3791	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy_of_ovarian_neoplasm and poor prognosis in epithelial ovarian_cancer .
15302795	0	angiopoietin-2	23,37	angiopoietin-1	7,21	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	Plasma|nummod|START_ENTITY Plasma|nummod|END_ENTITY	Plasma angiopoietin-1 , angiopoietin-2 , angiopoietin receptor tie-2 , and vascular_endothelial_growth_factor levels in acute_coronary_syndromes .
17451406	0	angiopoietin-2	112,126	angiopoietin-1	94,108	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	correlate|amod|START_ENTITY END_ENTITY|nmod|correlate	Serum concentrations of angiogenic cytokines in Waldenstrom_macroglobulinaemia : the ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity .
18182823	0	angiopoietin-2	65,79	angiopoietin-1	16,30	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	favor|nmod|START_ENTITY favor|nsubj|Balance Balance|acl|END_ENTITY	Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic_plaques with high microvessel density .
18287135	0	angiopoietin-2	45,59	angiopoietin-1	27,41	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|nmod|ratio	Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib .
22642477	0	angiopoietin-2	61,75	angiopoietin-1	76,90	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	Dynamic changes in serum angiopoietin-1 , angiopoietin-2 , and angiopoietin-2 / angiopoietin-1 ratio in acute_myocardial_infarction patients treated with primary percutaneous coronary intervention .
23915833	0	angiopoietin-2	7,21	angiopoietin-1	22,36	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|ratio ratio|amod|END_ENTITY	A high angiopoietin-2 / angiopoietin-1 ratio is associated with a high risk of septic_shock in patients with febrile_neutropenia .
25161936	0	angiopoietin-2	59,73	angiopoietin-1	43,57	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	ratio|amod|START_ENTITY ratio|amod|END_ENTITY	Effects of laser photocoagulation on serum angiopoietin-1 , angiopoietin-2 , angiopoietin-1 / angiopoietin-2 ratio , and soluble angiopoietin receptor Tie-2 levels in type 2 diabetic patients with proliferative_diabetic_retinopathy .
26463042	0	angiopoietin-2	31,45	angiopoietin-1	46,60	angiopoietin-2	angiopoietin-1	285	284	Gene	Gene	ratios|amod|START_ENTITY ratios|dep|END_ENTITY	Prognostic significance of the angiopoietin-2 / angiopoietin-1 and angiopoietin-1 / Tie-2 ratios for early_sepsis in an emergency_department .
17308086	0	angiopoietin-2	51,65	epidermal_growth_factor_receptor_2	6,40	angiopoietin-2	epidermal growth factor receptor 2	285	2064	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Human epidermal_growth_factor_receptor_2 regulates angiopoietin-2 expression in breast_cancer via AKT and mitogen-activated protein kinase pathways .
20213583	0	angiopoietin-2	18,32	hCG	41,44	angiopoietin-2	hCG	285	3342	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of the angiopoietin-2 gene by hCG in ovarian_cancer cell line OVCAR-3 .
12810677	0	angiopoietin-2	62,76	vascular_endothelial_growth_factor	14,48	angiopoietin-2	vascular endothelial growth factor	285	7422	Gene	Gene	up-regulates|amod|START_ENTITY up-regulates|compound|END_ENTITY	Tumor-derived vascular_endothelial_growth_factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature , supporting angiogenesis in ovarian_cancer .
20927337	0	angiopoietin-like_4	88,107	ANGPTL4	117,124	angiopoietin-like 4	ANGPTL4	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Decreased fat storage by Lactobacillus_paracasei is associated with increased levels of angiopoietin-like_4 protein -LRB- ANGPTL4 -RRB- .
23617883	0	angiopoietin-like_4	129,148	c-myc	114,119	angiopoietin-like 4	c-myc	51129	4609	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like_4 expression in malignant_glioma .
25685701	0	angiopoietin-like_4	24,43	lipoprotein_lipase	81,99	angiopoietin-like 4	lipoprotein lipase	57875(Tax:10090)	16956(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Differential effects of angiopoietin-like_4 in brain and muscle on regulation of lipoprotein_lipase activity .
19447061	0	angiopoietin-like_6	20,39	ANGPTL6	41,48	angiopoietin-like 6	ANGPTL6	83854	83854	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between angiopoietin-like_6 -LRB- ANGPTL6 -RRB- gene polymorphisms and metabolic_syndrome-related phenotypes in the French MONICA Study .
23469106	0	angiopoietin-like_protein_2	28,55	clock	12,17	angiopoietin-like protein 2	clock	23452	9575	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	A molecular clock regulates angiopoietin-like_protein_2 expression .
12518032	0	angiopoietin-like_protein_3	18,45	LXR	54,57	angiopoietin-like protein 3	LXR	30924(Tax:10090)	22259(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the angiopoietin-like_protein_3 gene by LXR .
26954186	0	angiopoietin-like_protein_4	25,52	ANGPTL4	54,61	angiopoietin-like protein 4	ANGPTL4	101104317	101104317	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	mRNA expression of ovine angiopoietin-like_protein_4 -LRB- ANGPTL4 -RRB- gene in adipose tissues .
18081944	0	angiopoietin-like_protein_4	14,41	fasting-induced_adipose_factor	42,72	angiopoietin-like protein 4	fasting-induced adipose factor	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	/|amod|START_ENTITY expression|amod|/ expression|amod|END_ENTITY	Regulation of angiopoietin-like_protein_4 / fasting-induced_adipose_factor -LRB- Angptl4/FIAF -RRB- expression in mouse white_adipose_tissue and 3T3-L1 adipocytes .
23383560	0	angiopoietin-related_growth_factor	6,40	AGF	42,45	angiopoietin-related growth factor	AGF	83854	83854	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum angiopoietin-related_growth_factor -LRB- AGF -RRB- levels are elevated_in_gestational_diabetes_mellitus and associated with insulin resistance .
23718665	0	angiopoietin-related_growth_factor	15,49	Angptl6	51,58	angiopoietin-related growth factor	Angptl6	83854	83854	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of angiopoietin-related_growth_factor -LRB- Angptl6 -RRB- during pregnancy and in pre-eclampsia .
26031531	0	angiopoietin_1	12,26	G-CSF	41,46	angiopoietin 1	G-CSF	11600(Tax:10090)	100036204(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Changes of angiopoietin_1 expression in G-CSF induced hematopoietic stem progenitor cells mobilization -RSB- .
11805186	0	angiopoietin_1	24,38	vascular_endothelial_growth_factor	76,110	angiopoietin 1	vascular endothelial growth factor	284	7422	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Human podocytes express angiopoietin_1 , a potential regulator of glomerular vascular_endothelial_growth_factor .
20088942	0	angiopoietin_2	47,61	oncostatin_M	26,38	angiopoietin 2	oncostatin M	285	5008	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The inflammatory mediator oncostatin_M induces angiopoietin_2 expression in endothelial cells in vitro and in vivo .
10506224	0	angiostatin	14,25	matrix_metalloproteinase-2	40,66	angiostatin	matrix metalloproteinase-2	18815(Tax:10090)	17390(Tax:10090)	Gene	Gene	production|compound|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of angiostatin production by matrix_metalloproteinase-2 in a model of concomitant resistance .
18706898	0	angiotensin-I-converting_enzyme	108,139	ACE	141,144	angiotensin-I-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting_enzyme -LRB- ACE -RRB- gene in Mexican patients and binary restenosis after coronary stenting .
23271625	0	angiotensin-I-converting_enzyme	14,45	ACE	47,50	angiotensin-I-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Review on the angiotensin-I-converting_enzyme -LRB- ACE -RRB- inhibitor peptides from marine proteins .
18025526	0	angiotensin-II	29,43	Calsarcin-1	0,11	angiotensin-II	Calsarcin-1	11606(Tax:10090)	59006(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Calsarcin-1 protects against angiotensin-II induced cardiac_hypertrophy .
1650705	0	angiotensin-II	47,61	Neurotensin	0,11	angiotensin-II	Neurotensin	24179(Tax:10116)	299757(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Neurotensin inhibits the stimulatory effect of angiotensin-II and potassium on aldosterone secretion by rat zona glomerulosa cells .
1655395	0	angiotensin-II	49,63	protein_kinase-C	15,31	angiotensin-II	protein kinase-C	24179(Tax:10116)	24681(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Involvement of protein_kinase-C in the effect of angiotensin-II on adenosine_3 ' ,5 ' - monophosphate production in lactotroph cells .
21176342	0	angiotensin-II_type_1_receptor	15,45	at1	46,49	angiotensin-II type 1 receptor	at1	185	185	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Expression of angiotensin-II_type_1_receptor at1 mRNA in myeloid_leukemia -RSB- .
23056909	0	angiotensin-I_converting_enzyme	46,77	ACE	79,82	angiotensin-I converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Molecular recognition and regulation of human angiotensin-I_converting_enzyme -LRB- ACE -RRB- activity by natural inhibitory peptides .
8730292	0	angiotensin-I_converting_enzyme	4,35	ACE	37,40	angiotensin-I converting enzyme	ACE	1636	1636	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The angiotensin-I_converting_enzyme -LRB- ACE -RRB- gene I/D polymorphism and ACE levels in Pima Indians .
7723869	0	angiotensin-converting-enzyme	49,78	ACE	80,83	angiotensin-converting-enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Life-threatening angioedema as a side effect of angiotensin-converting-enzyme -LRB- ACE -RRB- inhibitors -RSB- .
9872248	0	angiotensin-converting-enzyme	10,39	ACE	41,44	angiotensin-converting-enzyme	ACE	1636	1636	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effect of angiotensin-converting-enzyme -LRB- ACE -RRB- inhibitor trandolapril on human diabetic_neuropathy : randomised double-blind controlled trial .
10536692	0	angiotensin-converting_enzyme	34,63	ACE	65,68	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Chronic AT1 receptor blockade and angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition in -LRB- CHF 146 -RRB- cardiomyopathic hamsters : effects on cardiac_hypertrophy and survival .
10593661	0	angiotensin-converting_enzyme	25,54	ACE	56,59	angiotensin-converting enzyme	ACE	610668(Tax:9615)	610668(Tax:9615)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Functional role of local angiotensin-converting_enzyme -LRB- ACE -RRB- in adrenal catecholamine secretion in vivo .
10694521	0	angiotensin-converting_enzyme	31,60	ACE	62,65	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Maximally recommended doses of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors do not completely prevent ACE-mediated formation of angiotensin_II in chronic_heart_failure .
10790965	0	angiotensin-converting_enzyme	12,41	ACE	43,46	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors on water-salt homeostasis in hypertensive patients living in Far North -RSB- .
10938492	0	angiotensin-converting_enzyme	29,58	ACE	60,63	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	First-dose hypotension after angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors in chronic_heart_failure : a comparison of enalapril and perindopril .
11043512	0	angiotensin-converting_enzyme	87,116	ACE	118,121	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting_enzyme -LRB- ACE -RRB- gene .
11377823	0	angiotensin-converting_enzyme	20,49	ACE	51,54	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Linkage analysis of angiotensin-converting_enzyme -LRB- ACE -RRB- insertion/deletion polymorphism and systemic_lupus_erythematosus .
11464681	0	angiotensin-converting_enzyme	48,77	ACE	79,82	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	-LSB- Acute_renal_failure , renal_artery_stenosis and angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor -RSB- .
12135325	0	angiotensin-converting_enzyme	28,57	ACE	59,62	angiotensin-converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Combination therapy with an angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor and a calcium antagonist : beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal_ablation .
12138046	2	angiotensin-converting_enzyme	124,153	ACE	155,158	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	My physician initially prescribed lisinopril , an angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor .
12209028	0	angiotensin-converting_enzyme	50,79	ACE	81,84	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Prevention of vascular_damage in scleroderma with angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition .
12677950	0	angiotensin-converting_enzyme	27,56	ACE	58,61	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Familial hyperactivity of angiotensin-converting_enzyme -LRB- ACE -RRB- -RSB- .
1290300	0	angiotensin-converting_enzyme	17,46	ACE	48,51	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Prevention with angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors -RSB- .
15071363	0	angiotensin-converting_enzyme	22,51	ACE	53,56	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Gender differences in angiotensin-converting_enzyme -LRB- ACE -RRB- activity and inhibition by enalaprilat in healthy volunteers .
15109972	0	angiotensin-converting_enzyme	50,79	ACE	81,84	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphic locus in the intron 16 of the human angiotensin-converting_enzyme -LRB- ACE -RRB- gene is not correlated with complex_regional_pain_syndrome_I -LRB- CRPS_I -RRB- .
1580276	0	angiotensin-converting_enzyme	16,45	ACE	47,50	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Blood pressure , angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors , and the kidney .
1580277	0	angiotensin-converting_enzyme	12,41	ACE	43,46	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	A decade of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition .
1646329	0	angiotensin-converting_enzyme	21,50	ACE	52,55	angiotensin-converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Effects of different angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors on ischemic isolated rat hearts : relationship between cardiac ACE inhibition and cardioprotection .
16900885	0	angiotensin-converting_enzyme	39,68	ACE	70,73	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Insertion-deletion polymorphism in the angiotensin-converting_enzyme -LRB- ACE -RRB- gene among Sudanese , Somalis , Emiratis , and Omanis .
17164796	0	angiotensin-converting_enzyme	19,48	ACE	50,53	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No contribution of angiotensin-converting_enzyme -LRB- ACE -RRB- gene variants to severe obesity : a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases .
17713861	0	angiotensin-converting_enzyme	15,44	ACE	46,49	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of angiotensin-converting_enzyme -LRB- ACE -RRB- gene insertion-deletion polymorphism with spondylarthropathies .
20162537	0	angiotensin-converting_enzyme	83,112	ACE	114,117	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Development of a fast liquid chromatography/mass spectrometry screening method for angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors in complex natural mixtures like snake venom .
21116821	0	angiotensin-converting_enzyme	34,63	ACE	65,68	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Adipocyte-derived lipids increase angiotensin-converting_enzyme -LRB- ACE -RRB- expression and modulate macrophage phenotype .
21467797	0	angiotensin-converting_enzyme	62,91	ACE	93,96	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	-LSB- Pharmacoeconomic evaluation of hypothetical over-the-counter angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors for the prevention of stroke in patients with grade I hypertension -RSB- .
2164636	0	angiotensin-converting_enzyme	28,57	ACE	59,62	angiotensin-converting enzyme	ACE	11421(Tax:10090)	11421(Tax:10090)	Gene	Gene	Transcription|nmod|START_ENTITY Transcription|appos|END_ENTITY	Transcription of testicular angiotensin-converting_enzyme -LRB- ACE -RRB- is initiated within the 12th intron of the somatic ACE gene .
23390188	0	angiotensin-converting_enzyme	27,56	ACE	58,61	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Gender difference of serum angiotensin-converting_enzyme -LRB- ACE -RRB- activity in DD genotype of ACE insertion/deletion polymorphism in elderly Chinese .
23741507	0	angiotensin-converting_enzyme	39,68	ACE	70,73	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms of the angiotensin-converting_enzyme -LRB- ACE -RRB- gene are associated with essential hypertension and increased ACE enzyme levels in Mexican individuals .
23973719	0	angiotensin-converting_enzyme	38,67	ACE	69,72	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	Gene|amod|START_ENTITY Gene|appos|END_ENTITY	The importance of association between angiotensin-converting_enzyme -LRB- ACE -RRB- Gene I/D polymorphism and diabetic_peripheral_neuropathy .
24995885	0	angiotensin-converting_enzyme	18,47	ACE	49,52	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotypes of the angiotensin-converting_enzyme -LRB- ACE -RRB- gene are associated with coronary_artery_disease but not with restenosis after coronary stenting .
25957986	0	angiotensin-converting_enzyme	38,67	ACE	69,72	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Short-term storage stability of serum angiotensin-converting_enzyme -LRB- ACE -RRB- activity .
25957986	0	angiotensin-converting_enzyme	38,67	ACE	69,72	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Short-term storage stability of serum angiotensin-converting_enzyme -LRB- ACE -RRB- activity .
6099390	0	angiotensin-converting_enzyme	28,57	ACE	59,62	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Effect of dietary sodium on angiotensin-converting_enzyme -LRB- ACE -RRB- inhibition and the acute hypotensive effect of enalapril -LRB- MK-421 -RRB- in essential hypertension .
7559159	0	angiotensin-converting_enzyme	11,40	ACE	42,45	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of angiotensin-converting_enzyme -LRB- ACE -RRB- from human spermatozoa during capacitation and acrosome reaction .
8256319	0	angiotensin-converting_enzyme	73,102	ACE	104,107	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Optimal treatment of chronic heart_failure -- with particular emphasis on angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors -RSB- .
8380220	0	angiotensin-converting_enzyme	29,58	ACE	60,63	angiotensin-converting enzyme	ACE	11421(Tax:10090)	11421(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Sperm-specific expression of angiotensin-converting_enzyme -LRB- ACE -RRB- is mediated by a 91-base-pair promoter containing a CRE-like element .
9230757	0	angiotensin-converting_enzyme	20,49	ACE	51,54	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the angiotensin-converting_enzyme -LRB- ACE -RRB- gene and sarcoidosis .
9503533	0	angiotensin-converting_enzyme	134,163	ACE	165,168	angiotensin-converting enzyme	ACE	1636	1636	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Change of circadian pattern of arterial pressure in patients with congestive_heart_failure treated with perindopril , an inhibitor of angiotensin-converting_enzyme -LRB- ACE -RRB- -RSB- .
12093364	0	angiotensin-converting_enzyme	19,48	Ance	0,4	angiotensin-converting enzyme	Ance	34805(Tax:7227)	34805(Tax:7227)	Gene	Gene	homologue|amod|START_ENTITY END_ENTITY|appos|homologue	Ance , a Drosophila angiotensin-converting_enzyme homologue , is expressed in imaginal cells during metamorphosis and is regulated by the steroid , 20-hydroxyecdysone .
16465461	0	angiotensin-converting_enzyme	18,47	Apolipoprotein_E	0,16	angiotensin-converting enzyme	Apolipoprotein E	1636	348	Gene	Gene	polymorphisms|amod|START_ENTITY END_ENTITY|appos|polymorphisms	Apolipoprotein_E , angiotensin-converting_enzyme and kallikrein gene polymorphisms and the risk of Alzheimer 's _ disease and vascular_dementia .
11345366	0	angiotensin-converting_enzyme	108,137	Bradykinin	0,10	angiotensin-converting enzyme	Bradykinin	1636	3827	Gene	Gene	inhibitors|amod|START_ENTITY effects|nmod|inhibitors release|dep|effects stimulates|dobj|release stimulates|nsubj|END_ENTITY	Bradykinin stimulates the release of tissue_plasminogen_activator in human coronary circulation : effects of angiotensin-converting_enzyme inhibitors .
11684627	0	angiotensin-converting_enzyme	61,90	Bradykinin	0,10	angiotensin-converting enzyme	Bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY effects|nmod|inhibition contributes|nmod|effects contributes|nsubj|END_ENTITY	Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting_enzyme inhibition in patients with heart_failure .
12019275	0	angiotensin-converting_enzyme	72,101	Bradykinin	0,10	angiotensin-converting enzyme	Bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY ventricular|nmod|inhibition improves|dep|ventricular improves|nsubj|END_ENTITY	Bradykinin improves left ventricular diastolic function under long-term angiotensin-converting_enzyme inhibition in heart_failure .
15105283	0	angiotensin-converting_enzyme	70,99	Bradykinin	0,10	angiotensin-converting enzyme	Bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY effects|nmod|inhibition contributes|nmod|effects contributes|nsubj|END_ENTITY	Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting_enzyme inhibition in patients with heart_failure .
18728246	0	angiotensin-converting_enzyme	14,43	CD143	45,50	angiotensin-converting enzyme	CD143	1636	1636	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of angiotensin-converting_enzyme -LRB- CD143 -RRB- identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells .
23468166	0	angiotensin-converting_enzyme	15,44	FABP2	85,90	angiotensin-converting enzyme	FABP2	1636	2169	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association of angiotensin-converting_enzyme -LRB- ACE -RRB- and fatty_acid binding protein 2 -LRB- FABP2 -RRB- genes polymorphism with type 2 diabetes_mellitus in Northern India .
25501306	0	angiotensin-converting_enzyme	30,59	PAI-1	105,110	angiotensin-converting enzyme	PAI-1	1636	5054	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Polymorphism and synergism of angiotensin-converting_enzyme -LRB- ACE -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- genes in coronary_artery_disease .
9353383	0	angiotensin-converting_enzyme	10,39	Renin	0,5	angiotensin-converting enzyme	Renin	24310(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Renin vs. angiotensin-converting_enzyme inhibition in the rat : consequences for plasma and renal tissue angiotensin .
24516103	0	angiotensin-converting_enzyme	59,88	Substance_P	0,11	angiotensin-converting enzyme	Substance P	1636	6863	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Substance_P increases sympathetic activity during combined angiotensin-converting_enzyme and dipeptidyl_peptidase-4 inhibition .
12805239	0	angiotensin-converting_enzyme	41,70	angiotensin_I	90,103	angiotensin-converting enzyme	angiotensin I	11421(Tax:10090)	11606(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cleavage cleavage|nmod|END_ENTITY	Roles of the two active sites of somatic angiotensin-converting_enzyme in the cleavage of angiotensin_I and bradykinin : insights from selective inhibitors .
21115616	0	angiotensin-converting_enzyme	11,40	angiotensin_I	77,90	angiotensin-converting enzyme	angiotensin I	11421(Tax:10090)	11606(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|infusion infusion|amod|END_ENTITY	Intrarenal angiotensin-converting_enzyme induces hypertension in response to angiotensin_I infusion .
21546583	0	angiotensin-converting_enzyme	131,160	angiotensin_I	72,85	angiotensin-converting enzyme	angiotensin I	1636	183	Gene	Gene	activity|acl|START_ENTITY END_ENTITY|dep|activity	Carboxypeptidase activity common to viridans group streptococci cleaves angiotensin_I to angiotensin_II : an activity homologous to angiotensin-converting_enzyme -LRB- ACE -RRB- .
2846041	0	angiotensin-converting_enzyme	47,76	angiotensin_I	13,26	angiotensin-converting enzyme	angiotensin I	1636	183	Gene	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Catalysis of angiotensin_I hydrolysis by human angiotensin-converting_enzyme : effect of chloride and pH. The catalysis of the hydrolysis of angiotensin_I , an important natural substrate , by human angiotensin-converting_enzyme -LRB- ACE -RRB- was examined in detail as a function of chloride and hydrogen ion concentration .
7768572	0	angiotensin-converting_enzyme	99,128	angiotensin_I	29,42	angiotensin-converting enzyme	angiotensin I	1636	183	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Enhanced pressor response to angiotensin_I in normotensive men with the deletion genotype -LRB- DD -RRB- for angiotensin-converting_enzyme .
9476561	1	angiotensin-converting_enzyme	80,109	angiotensin_I	141,154	angiotensin-converting enzyme	angiotensin I	1636	183	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of angiotensin_II , angiotensin-converting_enzyme , and alternative conversion of angiotensin_I .
16769060	0	angiotensin-converting_enzyme	50,79	angiotensin_II	16,30	angiotensin-converting enzyme	angiotensin II	1636	183	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of angiotensin_II , the AT1 receptor , angiotensin-converting_enzyme , aminopeptidase_A , adipocyte-derived_leucine_aminopeptidase , and vascular_endothelial_growth_factor in the human ovary throughout the menstrual cycle .
8385419	0	angiotensin-converting_enzyme	38,67	angiotensin_II	89,103	angiotensin-converting enzyme	angiotensin II	1636	183	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Structure and regulated expression of angiotensin-converting_enzyme and the receptor for angiotensin_II .
8973755	0	angiotensin-converting_enzyme	30,59	angiotensin_II	63,77	angiotensin-converting enzyme	angiotensin II	24310(Tax:10116)	24179(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Tissue-specific regulation of angiotensin-converting_enzyme by angiotensin_II and losartan in the rat .
10080484	0	angiotensin-converting_enzyme	87,116	bradykinin	149,159	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY inhibition|dep|role role|nmod|END_ENTITY	Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting_enzyme inhibition : a potential role of bradykinin .
10191623	0	angiotensin-converting_enzyme	9,38	bradykinin	42,52	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	START_ENTITY|nmod|provocation provocation|amod|END_ENTITY	-LSB- Role of angiotensin-converting_enzyme on bradykinin nasal provocation : comparison of normal volunteers and allergic subjects -RSB- .
10547087	0	angiotensin-converting_enzyme	86,115	bradykinin	10,20	angiotensin-converting enzyme	bradykinin	610668(Tax:9615)	478666(Tax:9615)	Gene	Gene	inhibition|nmod|START_ENTITY accompany|nmod|inhibition accompany|nsubj|levels levels|compound|END_ENTITY	Increased bradykinin levels accompany the hemodynamic response to acute inhibition of angiotensin-converting_enzyme in dogs with heart_failure .
10604961	0	angiotensin-converting_enzyme	75,104	bradykinin	61,71	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	humans|amod|START_ENTITY END_ENTITY|nmod|humans	Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting_enzyme inhibitor-treated humans .
10749699	0	angiotensin-converting_enzyme	30,59	bradykinin	16,26	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of bradykinin by angiotensin-converting_enzyme and by carboxypeptidase N in human plasma .
1282628	0	angiotensin-converting_enzyme	13,42	bradykinin	106,116	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY Influence|nmod|inhibition Influence|dep|roles roles|nmod|END_ENTITY	Influence of angiotensin-converting_enzyme inhibition on sympathetic neurotransmission : possible roles of bradykinin and prostaglandins .
1282634	0	angiotensin-converting_enzyme	62,91	bradykinin	112,122	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibitors|amod|START_ENTITY effects|nmod|inhibitors Heterogeneity|nmod|effects Heterogeneity|dep|role role|nmod|generation generation|compound|END_ENTITY	Heterogeneity of endothelium-dependent vasodilator effects of angiotensin-converting_enzyme inhibitors : role of bradykinin generation during ACE inhibition .
15492133	0	angiotensin-converting_enzyme	98,127	bradykinin	62,72	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY treated|nmod|inhibition patients|acl|treated END_ENTITY|nmod|patients	Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting_enzyme inhibition .
1663586	0	angiotensin-converting_enzyme	86,115	bradykinin	20,30	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibitors|amod|START_ENTITY produced|nmod|inhibitors calcium|acl|produced increase|nmod|calcium responsible|nmod|increase responsible|nsubj|END_ENTITY	Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting_enzyme inhibitors in human endothelial cells .
17460297	0	angiotensin-converting_enzyme	58,87	bradykinin	105,115	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	choroidal_neovascularization|nmod|START_ENTITY Suppression|nmod|choroidal_neovascularization Suppression|dep|role role|nmod|END_ENTITY	Suppression of choroidal_neovascularization by inhibiting angiotensin-converting_enzyme : minimal role of bradykinin .
21651905	0	angiotensin-converting_enzyme	12,41	bradykinin	115,125	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	endopeptidase|amod|START_ENTITY endopeptidase|dep|END_ENTITY	Endothelial angiotensin-converting_enzyme and neutral endopeptidase in isolated human umbilical vein : an effective bradykinin inactivation pathway .
2185292	0	angiotensin-converting_enzyme	28,57	bradykinin	154,164	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	responses|amod|START_ENTITY mechanism|nmod|responses Studies|nmod|mechanism Studies|acl|END_ENTITY	Studies of the mechanism of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor-associated angioedema : the effect of an ACE inhibitor on cutaneous responses to bradykinin , codeine , and histamine .
4377109	0	angiotensin-converting_enzyme	54,83	bradykinin	14,24	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of bradykinin and its higher homologues by angiotensin-converting_enzyme .
8964127	0	angiotensin-converting_enzyme	20,49	bradykinin	91,101	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	polymorphism|amod|START_ENTITY relation|nmod|polymorphism relation|acl|END_ENTITY	No relation between angiotensin-converting_enzyme gene polymorphism and dermal response to bradykinin in healthy subjects .
9374762	0	angiotensin-converting_enzyme	16,45	bradykinin	75,85	angiotensin-converting enzyme	bradykinin	1636	3827	Gene	Gene	START_ENTITY|nmod|metabolism metabolism|nmod|END_ENTITY	Contribution of angiotensin-converting_enzyme to the cardiac metabolism of bradykinin : an interspecies study .
11713892	0	angiotensin-converting_enzyme	44,73	growth_hormone	11,25	angiotensin-converting enzyme	growth hormone	24310(Tax:10116)	81668(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Effects of growth_hormone following chronic angiotensin-converting_enzyme inhibition in chronic_heart_failure : their relation to infarct size .
3027766	0	angiotensin-converting_enzyme	41,70	kininase_II	81,92	angiotensin-converting enzyme	kininase II	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Compensatory increase in adrenomedullary angiotensin-converting_enzyme activity -LRB- kininase_II -RRB- after unilateral adrenalectomy .
10371365	0	angiotensin-converting_enzyme	45,74	neutral_endopeptidase	75,96	angiotensin-converting enzyme	neutral endopeptidase	1636	4311	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Sustained antihypertensive actions of a dual angiotensin-converting_enzyme neutral_endopeptidase inhibitor , sampatrilat , in black hypertensive subjects .
15286094	0	angiotensin-converting_enzyme	52,81	neutral_endopeptidase	82,103	angiotensin-converting enzyme	neutral endopeptidase	1636	4311	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Pharmacokinetics of M100240 and MDL 100,173 , a dual angiotensin-converting_enzyme / neutral_endopeptidase inhibitor , in healthy young and elderly volunteers .
8558518	2	angiotensin-converting_enzyme	127,156	neutral_endopeptidase	157,178	angiotensin-converting enzyme	neutral endopeptidase	1636	4311	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Incorporation of bicyclic and substituted monocyclic_azepinones as dipeptide surrogates in angiotensin-converting_enzyme / neutral_endopeptidase inhibitors .
16488667	0	angiotensin-converting_enzyme	36,65	urocortin	23,32	angiotensin-converting enzyme	urocortin	24310(Tax:10116)	29151(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of intravenous urocortin on angiotensin-converting_enzyme in rats .
20237592	0	angiotensin-converting_enzyme	72,101	urocortin	35,44	angiotensin-converting enzyme	urocortin	24310(Tax:10116)	29151(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of long-term treatment with urocortin on the activity of somatic angiotensin-converting_enzyme in spontaneously hypertensive rats .
27050505	0	angiotensin-converting_enzyme-1	5,36	ACE-1	38,43	angiotensin-converting enzyme-1	ACE-1	1636	1636	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Does angiotensin-converting_enzyme-1 -LRB- ACE-1 -RRB- gene polymorphism lead to chronic kidney_disease among hypertensive patients ?
23751363	0	angiotensin-converting_enzyme-2	27,58	Endothelin-1	0,12	angiotensin-converting enzyme-2	Endothelin-1	59272	1906	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Endothelin-1 downregulates angiotensin-converting_enzyme-2 expression in human bronchial epithelial cells .
12358520	0	angiotensin-converting_enzyme-related_carboxypeptidase	45,99	ACE2	101,105	angiotensin-converting enzyme-related carboxypeptidase	ACE2	59272	59272	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Substrate-based design of the first class of angiotensin-converting_enzyme-related_carboxypeptidase -LRB- ACE2 -RRB- inhibitors .
15693124	0	angiotensin-converting_enzyme_2	70,101	ACE2	103,107	angiotensin-converting enzyme 2	ACE2	70008(Tax:10090)	70008(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Cloning , expression and sequence analysis and tissue distribution of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- gene in adult mice -RSB- .
21864606	0	angiotensin-converting_enzyme_2	45,76	ACE2	78,82	angiotensin-converting enzyme 2	ACE2	59272	59272	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Identifying the regulatory element for human angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- expression in human cardiofibroblasts .
24147777	0	angiotensin-converting_enzyme_2	25,56	ACE2	58,62	angiotensin-converting enzyme 2	ACE2	59272	59272	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Epigenetic regulation of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- by SIRT1 under conditions of cell energy stress .
24329564	0	angiotensin-converting_enzyme_2	8,39	ACE2	41,45	angiotensin-converting enzyme 2	ACE2	59272	59272	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- in diabetic_cardiovascular_complications .
24100303	0	angiotensin-converting_enzyme_2	53,84	HNF1a	25,30	angiotensin-converting enzyme 2	HNF1a	59272	6927	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The transcription factor HNF1a induces expression of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- in pancreatic islets from evolutionarily conserved promoter motifs .
24147777	0	angiotensin-converting_enzyme_2	25,56	SIRT1	67,72	angiotensin-converting enzyme 2	SIRT1	59272	23411	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of angiotensin-converting_enzyme_2 -LRB- ACE2 -RRB- by SIRT1 under conditions of cell energy stress .
24662240	0	angiotensin-converting_enzyme_2	18,49	neuraminidase	57,70	angiotensin-converting enzyme 2	neuraminidase	59272	4758	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Downregulation of angiotensin-converting_enzyme_2 by the neuraminidase protein of influenza_A _ -LRB- H1N1 -RRB- _ virus .
17676311	0	angiotensin_I	33,46	ACE	91,94	angiotensin I	ACE	183	1636	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Gradual reactivation of vascular angiotensin_I to angiotensin_II conversion during chronic ACE inhibitor therapy in patients with diabetes_mellitus .
18158355	0	angiotensin_I	78,91	Angiotensin-converting_enzyme	0,29	angiotensin I	Angiotensin-converting enzyme	11606(Tax:10090)	11421(Tax:10090)	Gene	Gene	cleavage|amod|START_ENTITY site|nmod|cleavage site|nsubj|domain domain|amod|END_ENTITY	Angiotensin-converting_enzyme C-terminal catalytic domain is the main site of angiotensin_I cleavage in vivo .
12805239	0	angiotensin_I	90,103	angiotensin-converting_enzyme	41,70	angiotensin I	angiotensin-converting enzyme	11606(Tax:10090)	11421(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY END_ENTITY|nmod|cleavage	Roles of the two active sites of somatic angiotensin-converting_enzyme in the cleavage of angiotensin_I and bradykinin : insights from selective inhibitors .
21115616	0	angiotensin_I	77,90	angiotensin-converting_enzyme	11,40	angiotensin I	angiotensin-converting enzyme	11606(Tax:10090)	11421(Tax:10090)	Gene	Gene	infusion|amod|START_ENTITY induces|nmod|infusion induces|nsubj|END_ENTITY	Intrarenal angiotensin-converting_enzyme induces hypertension in response to angiotensin_I infusion .
21546583	0	angiotensin_I	72,85	angiotensin-converting_enzyme	131,160	angiotensin I	angiotensin-converting enzyme	183	1636	Gene	Gene	START_ENTITY|dep|activity activity|acl|END_ENTITY	Carboxypeptidase activity common to viridans group streptococci cleaves angiotensin_I to angiotensin_II : an activity homologous to angiotensin-converting_enzyme -LRB- ACE -RRB- .
2846041	0	angiotensin_I	13,26	angiotensin-converting_enzyme	47,76	angiotensin I	angiotensin-converting enzyme	183	1636	Gene	Gene	hydrolysis|amod|START_ENTITY hydrolysis|nmod|END_ENTITY	Catalysis of angiotensin_I hydrolysis by human angiotensin-converting_enzyme : effect of chloride and pH. The catalysis of the hydrolysis of angiotensin_I , an important natural substrate , by human angiotensin-converting_enzyme -LRB- ACE -RRB- was examined in detail as a function of chloride and hydrogen ion concentration .
7768572	0	angiotensin_I	29,42	angiotensin-converting_enzyme	99,128	angiotensin I	angiotensin-converting enzyme	183	1636	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Enhanced pressor response to angiotensin_I in normotensive men with the deletion genotype -LRB- DD -RRB- for angiotensin-converting_enzyme .
9476561	1	angiotensin_I	141,154	angiotensin-converting_enzyme	80,109	angiotensin I	angiotensin-converting enzyme	183	1636	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of angiotensin_II , angiotensin-converting_enzyme , and alternative conversion of angiotensin_I .
190881	0	angiotensin_I	14,27	angiotensin_II	31,45	angiotensin I	angiotensin II	183	183	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|nmod|END_ENTITY	Conversion of angiotensin_I to angiotensin_II .
11747312	0	angiotensin_I	27,40	angiotensinogen	65,80	angiotensin I	angiotensinogen	183	183	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release and degradation of angiotensin_I and angiotensin_II from angiotensinogen by neutrophil serine proteinases .
10506486	0	angiotensin_I-converting_enzyme	24,55	ACE	57,60	angiotensin I-converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sustained inhibition of angiotensin_I-converting_enzyme -LRB- ACE -RRB- expression and long-term antihypertensive action by virally mediated delivery of ACE antisense cDNA .
1319114	0	angiotensin_I-converting_enzyme	80,111	ACE	113,116	angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence , from combined segregation and linkage analysis , that a variant of the angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene controls plasma ACE levels .
15720304	0	angiotensin_I-converting_enzyme	22,53	ACE	55,58	angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SNP haplotypes in the angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene : analysis of Nigerian family data using gamete competition models .
20214946	0	angiotensin_I-converting_enzyme	38,69	ACE	71,74	angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Arachin derived peptides as selective angiotensin_I-converting_enzyme -LRB- ACE -RRB- inhibitors : structure-activity relationship .
20518725	0	angiotensin_I-converting_enzyme	131,162	ACE	164,167	angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Migraine_and_coronary_artery_disease : an open study on the genetic polymorphism of the 5 , 10 methylenetetrahydrofolate -LRB- MTHFR -RRB- and angiotensin_I-converting_enzyme -LRB- ACE -RRB- genes .
21895753	0	angiotensin_I-converting_enzyme	29,60	ACE	62,65	angiotensin I-converting enzyme	ACE	1636	100064801(Tax:9796)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of acute exercise on angiotensin_I-converting_enzyme -LRB- ACE -RRB- activity in horses .
23560051	0	angiotensin_I-converting_enzyme	32,63	ACE	65,68	angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel splice-site mutation in angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene , c. 3691 +1 G > A -LRB- IVS25 +1 G > A -RRB- , causes a dramatic increase in circulating ACE through deletion of the transmembrane anchor .
23561096	0	angiotensin_I-converting_enzyme	109,140	ACE	142,145	angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Simulated digestion of proanthocyanidins in grape skin and seed extracts and the effects of digestion on the angiotensin_I-converting_enzyme -LRB- ACE -RRB- inhibitory activity .
8651305	0	angiotensin_I-converting_enzyme	43,74	ACE	76,79	angiotensin I-converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of new polymorphisms of the angiotensin_I-converting_enzyme -LRB- ACE -RRB- gene , and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis .
16822235	0	angiotensin_I-converting_enzyme_2	27,60	ACE2	21,25	angiotensin I-converting enzyme 2	ACE2	59272	59272	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Association study of ACE2 -LRB- angiotensin_I-converting_enzyme_2 -RRB- gene polymorphisms with coronary_heart_disease and myocardial_infarction in a Chinese Han population .
10361449	0	angiotensin_II	13,27	ACE	128,131	angiotensin II	ACE	183	1636	Gene	Gene	antagonists|amod|START_ENTITY antagonists|nmod|drug drug|nmod|treatment treatment|nmod|inhibitors inhibitors|amod|chronic_heart_failure chronic_heart_failure|nmod|END_ENTITY	-LSB- Efficacy of angiotensin_II receptor antagonists as a novel drug for the treatment of chronic_heart_failure -- in comparison with ACE inhibitors -RSB- .
10377310	0	angiotensin_II	14,28	ACE	82,85	angiotensin II	ACE	183	1636	Gene	Gene	concentrations|compound|START_ENTITY raised|nsubjpass|concentrations raised|nmod|treatment treatment|compound|END_ENTITY	How often are angiotensin_II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac_failure ?
10610744	0	angiotensin_II	42,56	ACE	65,68	angiotensin II	ACE	183	1636	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Clinical implications of increased plasma angiotensin_II despite ACE inhibitor therapy in patients with congestive_heart_failure .
10690317	0	angiotensin_II	35,49	ACE	59,62	angiotensin II	ACE	183	1636	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Vasoconstriction by in situ formed angiotensin_II : role of ACE and chymase .
10694521	0	angiotensin_II	130,144	ACE	62,65	angiotensin II	ACE	183	1636	Gene	Gene	formation|nmod|START_ENTITY prevent|dobj|formation prevent|nsubj|doses doses|nmod|inhibitors inhibitors|appos|END_ENTITY	Maximally recommended doses of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitors do not completely prevent ACE-mediated formation of angiotensin_II in chronic_heart_failure .
11263608	0	angiotensin_II	58,72	ACE	31,34	angiotensin II	ACE	183	1636	Gene	Gene	generation|compound|START_ENTITY Angiotensin_converting_enzyme|dobj|generation Angiotensin_converting_enzyme|dep|END_ENTITY	Angiotensin_converting_enzyme -LRB- ACE -RRB- and non-ACE dependent angiotensin_II generation in resistance arteries from patients with heart_failure and coronary_heart_disease .
11774115	0	angiotensin_II	104,118	ACE	23,26	angiotensin II	ACE	24179(Tax:10116)	24310(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY combining|nmod|levels combining|dobj|inhibitor inhibitor|compound|END_ENTITY	Effect of combining an ACE inhibitor and an angiotensin_II receptor blocker on plasma and kidney tissue angiotensin_II levels .
1462860	0	angiotensin_II	82,96	ACE	20,23	angiotensin II	ACE	183	1636	Gene	Gene	formation|compound|START_ENTITY dependent|nmod|formation dependent|nsubj|Cardioprotection Cardioprotection|nmod|inhibitor inhibitor|compound|END_ENTITY	Cardioprotection of ACE inhibitor in ischemic heart is not dependent on the local angiotensin_II formation .
14984722	0	angiotensin_II	72,86	ACE	53,56	angiotensin II	ACE	24179(Tax:10116)	24310(Tax:10116)	Gene	Gene	antagonism|amod|START_ENTITY inhibition|nmod|antagonism inhibition|compound|END_ENTITY	Endothelial_dysfunction in congestive_heart_failure : ACE inhibition vs. angiotensin_II antagonism .
16337046	0	angiotensin_II	26,40	ACE	97,100	angiotensin II	ACE	183	1636	Gene	Gene	levels|amod|START_ENTITY increased|dobj|levels increased|nmod|inhibition inhibition|compound|END_ENTITY	Determinants of increased angiotensin_II levels in severe chronic_heart_failure patients despite ACE inhibition .
16387160	0	angiotensin_II	39,53	ACE	15,18	angiotensin II	ACE	183	1636	Gene	Gene	concentration|compound|START_ENTITY inhibition|nmod|concentration inhibition|nsubj|effects effects|nmod|END_ENTITY	The effects of ACE inhibition on serum angiotensin_II concentration following cardiac transplantation .
16810285	0	angiotensin_II	54,68	ACE	0,3	angiotensin II	ACE	183	1636	Gene	Gene	expression|nmod|START_ENTITY balance|dobj|expression role|acl|balance END_ENTITY|dep|role	ACE and ACE2 : their role to balance the expression of angiotensin_II and angiotensin - -LRB- 1-7 -RRB- .
1689424	0	angiotensin_II	57,71	ACE	79,82	angiotensin II	ACE	183	1636	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Reactive hyperreninemia is a major determinant of plasma angiotensin_II during ACE inhibition .
17466950	0	angiotensin_II	28,42	ACE	10,13	angiotensin II	ACE	24179(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ACE inhibitors on angiotensin_II in rat mesangial cells cultured in high glucose .
17676311	0	angiotensin_II	50,64	ACE	91,94	angiotensin II	ACE	183	1636	Gene	Gene	conversion|amod|START_ENTITY angiotensin_I|nmod|conversion angiotensin_I|nmod|therapy therapy|compound|END_ENTITY	Gradual reactivation of vascular angiotensin_I to angiotensin_II conversion during chronic ACE inhibitor therapy in patients with diabetes_mellitus .
17959639	0	angiotensin_II	56,70	ACE	0,3	angiotensin II	ACE	24179(Tax:10116)	24310(Tax:10116)	Gene	Gene	rats|nmod|START_ENTITY lung_injury|nmod|rats mediates|dobj|lung_injury mediates|nsubj|END_ENTITY	ACE mediates ventilator-induced lung_injury in rats via angiotensin_II but not bradykinin .
19463120	0	angiotensin_II	22,36	ACE	17,20	angiotensin II	ACE	183	1636	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	-LSB- Polymorphism of ACE , angiotensin_II , NO-synthase , estrogen_receptor genes and gender differences in their effects on development of cardiovascular_pathology -RSB- .
20634797	0	angiotensin_II	37,51	ACE	11,14	angiotensin II	ACE	183	1636	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of ACE inhibitors on cardiac angiotensin_II and aldosterone in humans : `` Relevance of lipophilicity and affinity for ACE '' .
21546583	0	angiotensin_II	89,103	ACE	162,165	angiotensin II	ACE	183	1636	Gene	Gene	angiotensin_I|nmod|START_ENTITY angiotensin_I|dep|activity activity|appos|END_ENTITY	Carboxypeptidase activity common to viridans group streptococci cleaves angiotensin_I to angiotensin_II : an activity homologous to angiotensin-converting_enzyme -LRB- ACE -RRB- .
21622682	0	angiotensin_II	57,71	ACE	17,20	angiotensin II	ACE	11606(Tax:10090)	11421(Tax:10090)	Gene	Gene	generation|amod|START_ENTITY endogenous|dobj|generation chymase|xcomp|endogenous chymase|nsubj|Contributions Contributions|nmod|END_ENTITY	Contributions of ACE and mast cell chymase to endogenous angiotensin_II generation and leucocyte recruitment in vivo .
26937347	0	angiotensin_II	96,110	ACE	72,75	angiotensin II	ACE	183	1636	Gene	Gene	levels|compound|START_ENTITY modulated|dobj|levels modulated|nsubj|modulates modulates|acl|perfusion perfusion|nmod|correspondence correspondence|nmod|I/D I/D|compound|END_ENTITY	Exercise intensity modulates capillary perfusion in correspondence with ACE I/D modulated serum angiotensin_II levels .
8026000	0	angiotensin_II	18,32	ACE	99,102	angiotensin II	ACE	183	1636	Gene	Gene	Effect|nmod|START_ENTITY suppression|nsubj|Effect suppression|xcomp|furosemide furosemide|nmod|inhibition inhibition|compound|END_ENTITY	Effect of intense angiotensin_II suppression on the diuretic response to furosemide during chronic ACE inhibition .
8521580	0	angiotensin_II	56,70	ACE	11,14	angiotensin II	ACE	24179(Tax:10116)	24310(Tax:10116)	Gene	Gene	circulating|nmod|START_ENTITY inhibitors|advcl|circulating inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of ACE inhibitors on circulating versus cardiac angiotensin_II in volume_overload-induced cardiac_hypertrophy in rats .
8569988	0	angiotensin_II	51,65	ACE	31,34	angiotensin II	ACE	183	1636	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|appos|END_ENTITY	Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphisms , angiotensin_II , ACE inhibitors and glomerulosclerosis -- a hypothesis .
8569988	0	angiotensin_II	51,65	ACE	67,70	angiotensin II	ACE	183	1636	Gene	Gene	polymorphisms|appos|START_ENTITY END_ENTITY|nsubj|polymorphisms	Angiotensin-converting_enzyme -LRB- ACE -RRB- polymorphisms , angiotensin_II , ACE inhibitors and glomerulosclerosis -- a hypothesis .
8583482	0	angiotensin_II	16,30	ACE	0,3	angiotensin II	ACE	183	1636	Gene	Gene	antagonists|nsubj|START_ENTITY inhibitors|xcomp|antagonists inhibitors|nsubj|END_ENTITY	ACE inhibitors , angiotensin_II antagonists and cough .
9249242	0	angiotensin_II	20,34	ACE	98,101	angiotensin II	ACE	183	1636	Gene	Gene	formation|amod|START_ENTITY Characterization|nmod|formation isolated|nsubj|Characterization isolated|nmod|inhibitors inhibitors|nmod|END_ENTITY	Characterization of angiotensin_II formation in human isolated bladder by selective inhibitors of ACE and human chymase : a functional and biochemical study .
9314414	0	angiotensin_II	6,20	ACE	94,97	angiotensin II	ACE	24179(Tax:10116)	24310(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|dep|effect effect|nmod|inhibition inhibition|compound|END_ENTITY	Renal angiotensin_II receptor regulation in two-kidney , one clip hypertensive rats : effect of ACE inhibition .
9723827	0	angiotensin_II	26,40	ACE	110,113	angiotensin II	ACE	183	1636	Gene	Gene	antagonist|amod|START_ENTITY therapy|nmod|antagonist Start|nmod|therapy losartan|nsubj|Start losartan|nmod|inhibitor inhibitor|compound|END_ENTITY	Start of therapy with the angiotensin_II antagonist losartan after immediate switch from pretreatment with an ACE inhibitor .
9793599	0	angiotensin_II	22,36	ACE	0,3	angiotensin II	ACE	183	1636	Gene	Gene	cough|amod|START_ENTITY inhibitor|dep|cough inhibitor|compound|END_ENTITY	ACE inhibitor - versus angiotensin_II blocker-induced cough and angioedema .
1974420	0	angiotensin_II	76,90	AII	92,95	angiotensin II	AII	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Binding and pharmacologic properties of peptides derived from human and rat angiotensin_II -LRB- AII -RRB- mRNA .
2998548	0	angiotensin_II	24,38	AII	40,43	angiotensin II	AII	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of rat brain angiotensin_II -LRB- AII -RRB- receptors by intravenous AII and low dietary Na + .
10079018	0	angiotensin_II	45,59	AT1	60,63	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	correction|compound|START_ENTITY correction|compound|END_ENTITY	Binding of the antagonist -LSB- 3H -RSB- candesartan to angiotensin_II AT1 receptor-transfected -LSB- correction of tranfected -RSB- Chinese_hamster ovary cells .
10193788	0	angiotensin_II	127,141	AT1	142,145	angiotensin II	AT1	183	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin_II AT1 receptors .
10193788	0	angiotensin_II	127,141	AT1	62,65	angiotensin II	AT1	183	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY expressing|dobj|receptors antagonists|xcomp|expressing antagonists|nsubj|Distinction Distinction|nmod|receptor receptor|compound|END_ENTITY	Distinction between surmountable and insurmountable selective AT1 receptor antagonists by use of CHO-K1 cells expressing human angiotensin_II AT1 receptors .
10194764	0	angiotensin_II	121,135	AT1	85,88	angiotensin II	AT1	183	185	Gene	Gene	analogs|nmod|START_ENTITY Determination|nmod|analogs Determination|appos|END_ENTITY	Determination of peptide contact points in the human angiotensin_II type I receptor -LRB- AT1 -RRB- with photosensitive analogs of angiotensin_II .
10194764	0	angiotensin_II	53,67	AT1	85,88	angiotensin II	AT1	183	185	Gene	Gene	receptor|amod|START_ENTITY points|nmod|receptor Determination|nmod|points Determination|appos|END_ENTITY	Determination of peptide contact points in the human angiotensin_II type I receptor -LRB- AT1 -RRB- with photosensitive analogs of angiotensin_II .
10201881	0	angiotensin_II	11,25	AT1	58,61	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	generation|amod|START_ENTITY generation|nmod|blockade blockade|compound|END_ENTITY	Intrarenal angiotensin_II generation and renal effects of AT1 receptor blockade .
10415517	0	angiotensin_II	17,31	AT1	107,110	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	Amplification|nmod|START_ENTITY Amplification|acl|signaling signaling|nmod|overexpression overexpression|nmod|receptor receptor|compound|END_ENTITY	Amplification of angiotensin_II signaling in cardiac myocytes by adenovirus-mediated overexpression of the AT1 receptor .
10443311	0	angiotensin_II	24,38	AT1	39,42	angiotensin II	AT1	183	185	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	-LSB- Are the antagonists of angiotensin_II AT1 receptors protectors of the kidney ? -RSB- .
10682705	0	angiotensin_II	7,21	AT1	22,25	angiotensin II	AT1	183	185	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Gerbil angiotensin_II AT1 receptors are highly expressed in the hippocampus and cerebral cortex during postnatal development .
11327630	0	angiotensin_II	4,18	AT1	19,22	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	irbesartan|compound|START_ENTITY irbesartan|nummod|END_ENTITY	The angiotensin_II AT1 receptor antagonist irbesartan prevents thromboxane_A2-induced vasoconstriction in the rat hind-limb vascular bed in vivo .
11697745	0	angiotensin_II	84,98	AT1	29,32	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY administration|nmod|blockers blockers|compound|END_ENTITY	Peripheral administration of AT1 receptor blockers and pressor responses to central angiotensin_II and sodium .
11861115	0	angiotensin_II	81,95	AT1	96,99	angiotensin II	AT1	183	185	Gene	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Structure elucidation and conformational properties of eprosartan , a non peptide angiotensin_II AT1 antagonist .
11963637	0	angiotensin_II	37,51	AT1	33,36	angiotensin II	AT1	183	185	Gene	Gene	antagonists|amod|START_ENTITY antagonists|nummod|END_ENTITY	-LSB- Efficacy-safety relationship of AT1 angiotensin_II receptor antagonists : current data -RSB- .
12006574	1	angiotensin_II	131,145	AT1	153,156	angiotensin II	AT1	183	185	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Distinct roles of the N-and C-terminal residues of angiotensin_II during AT1 receptor activation .
12127057	0	angiotensin_II	4,18	AT1	0,3	angiotensin II	AT1	183	185	Gene	Gene	receptor|compound|START_ENTITY receptor|nummod|END_ENTITY	AT1 angiotensin_II receptor mediates intracellular calcium mobilization in normal and cancerous breast cells in primary culture .
12215602	0	angiotensin_II	132,146	AT1	147,150	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Protection against ischemia and improvement of cerebral_blood_flow in genetically hypertensive rats by chronic pretreatment with an angiotensin_II AT1 antagonist .
12235231	0	angiotensin_II	43,57	AT1	26,29	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nummod|END_ENTITY	Nonpeptide antagonists of AT1 receptor for angiotensin_II delay the onset of acute_respiratory_distress_syndrome .
12602118	0	angiotensin_II	44,58	AT1	11,14	angiotensin II	AT1	183	185	Gene	Gene	blockade|nmod|START_ENTITY blockade|compound|END_ENTITY	Effects of AT1 and AT2 receptor blockade on angiotensin_II induced apoptosis of human renal proximal tubular epithelial cells .
12686508	0	angiotensin_II	29,43	AT1	44,47	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	antagonism|compound|START_ENTITY antagonism|nummod|END_ENTITY	Anti-inflammatory effects of angiotensin_II AT1 receptor antagonism prevent stress-induced gastric_injury .
12848769	0	angiotensin_II	96,110	AT1	111,114	angiotensin II	AT1	183	185	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Angiotensin_II dose-effect curves and Schild regression plots for characterization of different angiotensin_II AT1 receptor antagonists in clinical pharmacology .
1331171	0	angiotensin_II	47,61	AT1	62,65	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Balloon angioplasty enhances the expression of angiotensin_II AT1 receptors in neointima of rat aorta .
1338078	0	angiotensin_II	121,135	AT1	136,139	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Angiotensin_II increases proto-oncogene expression and phosphoinositide turnover in vascular smooth muscle cells via the angiotensin_II AT1 receptor .
14624277	0	angiotensin_II	8,22	AT1	23,26	angiotensin II	AT1	183	185	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Role of angiotensin_II AT1 receptor blockers in the treatment of arterial hypertension .
1480133	0	angiotensin_II	88,102	AT1	113,116	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Characterization of the binding of -LSB- 3H -RSB- L-158 ,809 : a new potent and selective nonpeptide angiotensin_II receptor -LRB- AT1 -RRB- antagonist radioligand .
1504808	0	angiotensin_II	57,71	AT1	88,91	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	neurons|nmod|START_ENTITY current|nmod|neurons Modulation|nmod|current Modulation|dep|involvement involvement|nmod|receptors receptors|compound|END_ENTITY	Modulation of net outward current in cultured neurons by angiotensin_II : involvement of AT1 and AT2 receptors .
15120479	0	angiotensin_II	67,81	AT1	19,22	angiotensin II	AT1	183	185	Gene	Gene	modes|nmod|START_ENTITY reveals|dobj|modes reveals|nsubj|Mutagenesis Mutagenesis|nmod|receptor receptor|compound|END_ENTITY	Mutagenesis of the AT1 receptor reveals different binding modes of angiotensin_II and -LSB- Sar1 -RSB- - angiotensin_II .
15120479	0	angiotensin_II	93,107	AT1	19,22	angiotensin II	AT1	183	185	Gene	Gene	modes|dep|START_ENTITY reveals|dobj|modes reveals|nsubj|Mutagenesis Mutagenesis|nmod|receptor receptor|compound|END_ENTITY	Mutagenesis of the AT1 receptor reveals different binding modes of angiotensin_II and -LSB- Sar1 -RSB- - angiotensin_II .
15148525	0	angiotensin_II	14,28	AT1	76,79	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|jaw_movements jaw_movements|nmod|receptors receptors|nummod|END_ENTITY	Evidence that angiotensin_II enhances apomorphine-induced jaw_movements via AT1 receptors in the ventrolateral striatum : studies by magnet-sensing system in freely moving rats .
15501693	0	angiotensin_II	36,50	AT1	76,79	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|contraction contraction|nmod|receptors receptors|nummod|END_ENTITY	High glucose concentration augments angiotensin_II mediated contraction via AT1 receptors in rat thoracic aorta .
15639476	0	angiotensin_II	86,100	AT1	0,3	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	supersensitivity|nmod|START_ENTITY coupling|nmod|supersensitivity receptors|dep|coupling receptors|nummod|END_ENTITY	AT1 receptors and L-type calcium channels : functional coupling in supersensitivity to angiotensin_II in diabetic rats .
15680481	0	angiotensin_II	93,107	AT1	123,126	angiotensin II	AT1	183	185	Gene	Gene	concentrations|nmod|START_ENTITY ATPase|nmod|concentrations inhibition|nmod|ATPase reversed|nsubjpass|inhibition reversed|nmod|antagonists antagonists|amod|END_ENTITY	Protein kinase C-mediated inhibition of renal Ca2 + ATPase by physiological concentrations of angiotensin_II is reversed by AT1 - and AT2-receptor antagonists .
15953595	0	angiotensin_II	58,72	AT1	54,57	angiotensin II	AT1	183	185	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Functional evidence that in the cardiovascular system AT1 angiotensin_II receptors are AT1B prejunctionally and AT1A postjunctionally .
16061493	0	angiotensin_II	12,26	AT1	27,30	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Presynaptic angiotensin_II AT1 receptors enhance inhibitory and excitatory synaptic neurotransmission to motoneurons and other ventral horn neurons in neonatal rat spinal cord .
16112405	0	angiotensin_II	92,106	AT1	16,19	angiotensin II	AT1	183	185	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Coexpression Coexpression|nmod|receptors receptors|compound|END_ENTITY	Coexpression of AT1 and AT2 receptors by human fibroblasts is associated with resistance to angiotensin_II .
16126915	0	angiotensin_II	8,22	AT1	60,63	angiotensin II	AT1	24179(Tax:10116)	11607(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|consumption consumption|nmod|receptor receptor|compound|END_ENTITY	Central angiotensin_II controls alcohol consumption via its AT1 receptor .
1618259	0	angiotensin_II	46,60	AT1	100,103	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY induced|nmod|injection Drinking|acl|induced blocked|nsubjpass|Drinking blocked|nmod|DuP_753 DuP_753|compound|END_ENTITY	Drinking induced by subcutaneous injection of angiotensin_II in the rat is blocked by the selective AT1 receptor antagonist DuP_753 but not by the selective AT2 receptor antagonist WL_19 .
16205776	0	angiotensin_II	31,45	AT1	46,49	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	antagonist|compound|START_ENTITY antagonist|compound|END_ENTITY	A centrally acting , anxiolytic angiotensin_II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding .
16443499	0	angiotensin_II	37,51	AT1	53,56	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|nummod|END_ENTITY	Agonistic antibodies directed at the angiotensin_II , AT1 receptor in preeclampsia .
16542148	0	angiotensin_II	82,96	AT1	97,100	angiotensin II	AT1	183	185	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	A role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin_II AT1 receptor .
16542179	0	angiotensin_II	45,59	AT1	60,63	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Immunohistochemical localization of distinct angiotensin_II AT1 receptor isoforms in the kidneys of the Sprague-Dawley_rat and the desert rodent Meriones crassus .
16565729	0	angiotensin_II	87,101	AT1	39,42	angiotensin II	AT1	183	185	Gene	Gene	affinity|nmod|START_ENTITY decreases|dobj|affinity decreases|nsubj|S-nitrosylation S-nitrosylation|nmod|cysteine cysteine|nmod|receptor receptor|compound|END_ENTITY	S-nitrosylation of cysteine 289 of the AT1 receptor decreases its binding affinity for angiotensin_II .
16601219	0	angiotensin_II	42,56	AT1	0,3	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	system|compound|START_ENTITY regulates|dobj|system regulates|nsubj|blockade blockade|nummod|END_ENTITY	AT1 receptor blockade regulates the local angiotensin_II system in cerebral microvessels from spontaneously hypertensive rats .
17004728	0	angiotensin_II	63,77	AT1	125,128	angiotensin II	AT1	183	185	Gene	Gene	START_ENTITY|acl|forming forming|nmod|affinity affinity|nmod|END_ENTITY	Design , synthesis , and incorporation of a_beta-turn mimetic in angiotensin_II forming novel pseudopeptides with affinity for AT1 and AT2 receptors .
17010318	0	angiotensin_II	62,76	AT1	78,81	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	immunohistochemistry|nmod|START_ENTITY receptors|amod|immunohistochemistry receptors|appos|END_ENTITY	The use of heat-induced hydrolysis in immunohistochemistry on angiotensin_II -LRB- AT1 -RRB- receptors enhances the immunoreactivity in paraformaldehyde-fixed brain tissue of normotensive Sprague-Dawley_rats .
17118791	0	angiotensin_II	56,70	AT1	91,94	angiotensin II	AT1	183	185	Gene	Gene	photolabel|nmod|START_ENTITY photolabel|nmod|receptor receptor|compound|END_ENTITY	Synthesis of an agonistic , difluoro-azido photolabel of angiotensin_II and labeling of the AT1 receptor : transmembrane domains 3 , 6 , and 7 form the ligand-binding pocket .
17239455	0	angiotensin_II	45,59	AT1	60,63	angiotensin II	AT1	183	185	Gene	Gene	transduction|amod|START_ENTITY transduction|compound|END_ENTITY	Participation of transmembrane_proline 82 in angiotensin_II AT1 receptor signal transduction .
1750504	0	angiotensin_II	47,61	AT1	63,66	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|nummod|END_ENTITY	Angiotensin-converting_enzyme inhibitor versus angiotensin_II , AT1 receptor antagonist .
17855497	0	angiotensin_II	46,60	AT1	76,79	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	circulating|dobj|START_ENTITY modulation|acl|circulating mediated|nsubjpass|modulation mediated|nmod|receptors receptors|nummod|END_ENTITY	Baroreceptor reflex modulation by circulating angiotensin_II is mediated by AT1 receptors in the nucleus tractus solitarius .
17879628	0	angiotensin_II	28,42	AT1	43,46	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Estimation of the number of angiotensin_II AT1 receptors in rat kidney afferent and efferent arterioles .
18310294	0	angiotensin_II	69,83	AT1	84,87	angiotensin II	AT1	183	185	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Anti-cancer actions of a recombinant antibody -LRB- R6313/G2 -RRB- against the angiotensin_II AT1 receptor .
18567710	0	angiotensin_II	76,90	AT1	136,139	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|advcl|increasing increasing|dobj|availability availability|nmod|receptors receptors|nummod|END_ENTITY	High intraluminal pressure via H2O2 upregulates arteriolar constrictions to angiotensin_II by increasing the functional availability of AT1 receptors .
19407469	0	angiotensin_II	14,28	AT1	77,80	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|receptor receptor|compound|END_ENTITY	The effect of angiotensin_II on the number of macula_densa cells through the AT1 receptor .
19726542	0	angiotensin_II	32,46	AT1	0,3	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	uptake|nmod|START_ENTITY receptor-mediated|dobj|uptake receptor-mediated|nsubj|END_ENTITY	AT1 receptor-mediated uptake of angiotensin_II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway .
20659889	0	angiotensin_II	107,121	AT1	122,125	angiotensin II	AT1	183	185	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Tumor necrosis factor receptor-associated factor-6 and ribosomal_S6_kinase intracellular pathways link the angiotensin_II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells .
21143281	0	angiotensin_II	25,39	AT1	52,55	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	actions|nmod|START_ENTITY mediated|nsubj|actions mediated|nmod|receptors receptors|compound|END_ENTITY	Physiological actions of angiotensin_II mediated by AT1 AND AT2 receptors in the brain .
24927350	0	angiotensin_II	38,52	AT1	61,64	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	type|compound|START_ENTITY immunization|nmod|type Effect|nmod|immunization Effect|appos|END_ENTITY	Effect of active immunization against angiotensin_II type 1 -LRB- AT1 -RRB- receptor on hypertension _ arterial remodelling in spontaneously hypertensive rats -LRB- SHR -RRB- .
25003108	0	angiotensin_II	60,74	AT1	75,78	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|compound|END_ENTITY	Fear-potentiated behaviour is modulated by central amygdala angiotensin_II AT1 receptors stimulation .
25218469	0	angiotensin_II	121,135	AT1	105,108	angiotensin II	AT1	183	185	Gene	Gene	receptor|nmod|START_ENTITY receptor|nummod|END_ENTITY	Down-regulation of ether-a-go-go-related gene potassium channel protein through sustained stimulation of AT1 receptor by angiotensin_II .
25238020	0	angiotensin_II	56,70	AT1	12,15	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	pathways|xcomp|START_ENTITY pathways|nsubj|END_ENTITY	Endothelial AT1 and AT2 pathways in aortic responses to angiotensin_II after stress and ethanol consumption in rats .
25682288	0	angiotensin_II	32,46	AT1	20,23	angiotensin II	AT1	183	185	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association between AT1 and AT2 angiotensin_II receptor expression with cell proliferation and angiogenesis in operable breast_cancer .
26268856	0	angiotensin_II	42,56	AT1	68,71	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY expression|nmod|receptors Changes|nmod|expression Changes|appos|END_ENTITY	Changes in protein and gene expression of angiotensin_II receptors -LRB- AT1 and AT2 -RRB- in aorta of diabetic and hypertensive rats .
7484434	0	angiotensin_II	100,114	AT1	125,128	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The relationship between the adrenal tissue renin-angiotensin system , internalization of the type I angiotensin_II receptor -LRB- AT1 -RRB- and angiotensin_II function in the rat adrenal zona_glomerulosa cell .
7493612	0	angiotensin_II	118,132	AT1	26,29	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY induced|nmod|injection drinking|acl|induced inhibits|dobj|drinking inhibits|nsubj|LR-B/081 LR-B/081|compound|END_ENTITY	The selective angiotensin AT1 receptor antagonist LR-B/081 potently inhibits drinking induced by central injection of angiotensin_II in rats .
7554134	0	angiotensin_II	24,38	AT1	39,42	angiotensin II	AT1	183	185	Gene	Gene	Upregulation|nmod|START_ENTITY END_ENTITY|nsubj|Upregulation	Upregulation of cardiac angiotensin_II AT1 receptors in congenital cardiomyopathic hamsters .
7562905	0	angiotensin_II	25,39	AT1	91,94	angiotensin II	AT1	183	185	Gene	Gene	antagonists|amod|START_ENTITY Potent|dobj|antagonists Potent|nmod|affinity affinity|nmod|END_ENTITY	Potent and orally active angiotensin_II receptor antagonists with equal affinity for human AT1 and AT2 subtypes .
7588383	0	angiotensin_II	30,44	AT1	55,58	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Internalisation of the type I angiotensin_II receptor -LRB- AT1 -RRB- and angiotensin_II function in the rat adrenal zona glomerulosa cell .
7686719	0	angiotensin_II	40,54	AT1	55,58	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Immunohistochemical localization of rat angiotensin_II AT1 receptor .
7746328	0	angiotensin_II	46,60	AT1	61,64	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Direct stimulation of Jak/STAT pathway by the angiotensin_II AT1 receptor .
7799397	0	angiotensin_II	37,51	AT1	105,108	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY Triazolinone_biphenylsulfonamides|nmod|antagonists Triazolinone_biphenylsulfonamides|nmod|END_ENTITY	Triazolinone_biphenylsulfonamides as angiotensin_II receptor antagonists with high affinity for both the AT1 and AT2 subtypes .
7831501	0	angiotensin_II	63,77	AT1	0,3	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nsubj|subtype subtype|nummod|END_ENTITY	AT1 receptor subtype mediates the inhibitory effect of central angiotensin_II on cerebrospinal fluid formation in the rat .
7869841	0	angiotensin_II	69,83	AT1	84,87	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Characterization of the binding of -LSB- 125I -RSB- L-735 ,286 : a new nonpeptide angiotensin_II AT1 receptor radioligand .
7952881	0	angiotensin_II	24,38	AT1	39,42	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	subtype|amod|START_ENTITY subtype|compound|END_ENTITY	Characterization of the angiotensin_II AT1 receptor subtype involved in DNA synthesis in cultured vascular smooth muscle cells .
7980607	0	angiotensin_II	154,168	AT1	55,58	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|Internalization Internalization|appos|END_ENTITY	Internalization of the type I angiotensin_II receptor -LRB- AT1 -RRB- is required for protein kinase C activation but not for inositol_trisphosphate release in the angiotensin_II stimulated rat adrenal zona glomerulosa cell .
7980607	0	angiotensin_II	30,44	AT1	55,58	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY Internalization|nmod|receptor Internalization|appos|END_ENTITY	Internalization of the type I angiotensin_II receptor -LRB- AT1 -RRB- is required for protein kinase C activation but not for inositol_trisphosphate release in the angiotensin_II stimulated rat adrenal zona glomerulosa cell .
7988654	0	angiotensin_II	21,35	AT1	97,100	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY antagonist|nmod|affinities affinities|nmod|END_ENTITY	EXP597 , a nonpeptide angiotensin_II receptor antagonist with high affinities for the angiotensin AT1 and AT2 receptor subtypes .
8046288	0	angiotensin_II	30,44	AT1	55,58	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Internalisation of the type I angiotensin_II receptor -LRB- AT1 -RRB- and angiotensin_II function in the rat adrenal zona glomerulosa cell .
8064808	0	angiotensin_II	62,76	AT1	101,104	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	antagonists|compound|START_ENTITY derivatives|nmod|antagonists derivatives|nmod|affinity affinity|compound|END_ENTITY	Triazolinone_biphenylsulfonamide derivatives as orally active angiotensin_II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity .
8336821	0	angiotensin_II	69,83	AT1	23,26	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	response|amod|START_ENTITY receptors|nmod|response receptors|nsubj|Effects Effects|nmod|blockade blockade|nmod|END_ENTITY	Effects of blockade of AT1 and AT2 receptors in brain on the central angiotensin_II pressor response in conscious spontaneously hypertensive rats .
8453478	0	angiotensin_II	62,76	AT1	25,28	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	response|compound|START_ENTITY role|nmod|response role|nmod|END_ENTITY	Functional role of brain AT1 and AT2 receptors in the central angiotensin_II pressor response .
8491041	0	angiotensin_II	63,77	AT1	26,29	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	response|amod|START_ENTITY roles|nmod|response roles|nmod|END_ENTITY	Functional roles of brain AT1 and AT2 receptors in the central angiotensin_II pressor response in conscious young spontaneously hypertensive rats .
8532590	0	angiotensin_II	22,36	AT1	53,56	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	retention|nmod|START_ENTITY mediated|nsubj|retention mediated|nmod|receptor receptor|compound|END_ENTITY	Impaired retention by angiotensin_II mediated by the AT1 receptor .
8545239	0	angiotensin_II	42,56	AT1	57,60	angiotensin II	AT1	183	185	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Glycyl-histidyl-lysine interacts with the angiotensin_II AT1 receptor .
8667363	0	angiotensin_II	45,59	AT1	31,34	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	antagonists|compound|START_ENTITY antagonists|compound|END_ENTITY	Diphenylpropionic_acids as new AT1 selective angiotensin_II antagonists .
8821729	0	angiotensin_II	15,29	AT1	30,33	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Stimulation of angiotensin_II AT1 receptors in rat median eminence increases phosphoinositide hydrolysis .
8904632	0	angiotensin_II	39,53	AT1	101,104	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|acl|reabsorption reabsorption|nmod|receptor receptor|compound|END_ENTITY	Modulation by locally produced luminal angiotensin_II of proximal tubular sodium reabsorption via an AT1 receptor .
8930186	0	angiotensin_II	79,93	AT1	17,20	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY receptors|nmod|interaction receptors|compound|END_ENTITY	Participation of AT1 and AT2 receptors in the differential interaction between angiotensin_II or III and alpha-2 adrenoceptors in the nucleus reticularis gigantocellularis in cardiovascular regulation and antinociception in rats .
8993847	0	angiotensin_II	25,39	AT1	52,55	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	actions|nmod|START_ENTITY mediated|nsubj|actions mediated|nmod|receptors receptors|compound|END_ENTITY	Physiological actions of angiotensin_II mediated by AT1 and AT2 receptors in the brain .
9003008	0	angiotensin_II	67,81	AT1	33,36	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9003008	0	angiotensin_II	67,81	AT1	90,93	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nmod|receptor receptor|compound|END_ENTITY	Angiotensin_II receptor subtypes AT1 and AT2 are down-regulated by angiotensin_II through AT1 receptor by different mechanisms .
9024263	0	angiotensin_II	25,39	AT1	41,44	angiotensin II	AT1	183	185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Somatic mutations of the angiotensin_II -LRB- AT1 -RRB- receptor gene are not present in aldosterone-producing adenoma .
9081679	0	angiotensin_II	127,141	AT1	22,25	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY subtypes|nmod|stimulation subtypes|nsubj|roles roles|nmod|receptor receptor|compound|END_ENTITY	Differential roles of AT1 and AT2 receptor subtypes in vascular trophic and phenotypic changes in response to stimulation with angiotensin_II .
9101313	0	angiotensin_II	58,72	AT1	108,111	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY Recognition|nmod|receptors Recognition|acl|using using|dobj|antibodies antibodies|nmod|receptors receptors|compound|END_ENTITY	Recognition of tissue - and subtype-specific modulation of angiotensin_II receptors using antibodies against AT1 and AT2 receptors .
9115844	0	angiotensin_II	84,98	AT1	59,62	angiotensin II	AT1	183	185	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|receptors receptors|compound|END_ENTITY	Modulation of membrane potential and ionic currents by the AT1 and AT2 receptors of angiotensin_II .
9152365	0	angiotensin_II	61,75	AT1	43,46	angiotensin II	AT1	183	185	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Losartan , a selective inhibitor of subtype AT1 receptors for angiotensin_II , inhibits the binding of N-formylmethionyl-leucyl-phenylalanine to neutrophil receptors .
9200674	0	angiotensin_II	51,65	AT1	0,3	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY responses|acl|induced mediate|dobj|responses mediate|nsubj|receptors receptors|compound|END_ENTITY	AT1 receptors mediate pressor responses induced by angiotensin_II in the periaqueductal gray area of rats .
9285642	0	angiotensin_II	69,83	AT1	31,34	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	downregulates|nsubj|START_ENTITY talk|parataxis|downregulates talk|nmod|receptors receptors|compound|angiotensin angiotensin|nummod|END_ENTITY	Cross talk between angiotensin AT1 and alpha 1-adrenergic receptors : angiotensin_II downregulates alpha_1a-adrenergic_receptor subtype mRNA and density in neonatal rat cardiac myocytes .
9287353	0	angiotensin_II	117,131	AT1	132,135	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin_II AT1 receptor .
9413025	0	angiotensin_II	37,51	AT1	104,107	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Dose-dependent inhibitory effects of angiotensin_II on visual responses of the rat superior colliculus : AT1 and AT2 receptor contributions .
9453258	0	angiotensin_II	42,56	AT1	57,60	angiotensin II	AT1	183	185	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Localization and functional properties of angiotensin_II AT1 receptors in the kidney : focus on renomedullary interstitial cells .
9514193	0	angiotensin_II	57,71	AT1	8,11	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|receptors receptors|compound|END_ENTITY	Role of AT1 and AT2 receptors in the plasma clearance of angiotensin_II .
9537671	0	angiotensin_II	4,18	AT1	96,99	angiotensin II	AT1	183	185	Gene	Gene	site|compound|START_ENTITY distinct|nsubj|site distinct|nmod|END_ENTITY	The angiotensin_II binding site on Mycoplasma_hyorhynis is structurally distinct from mammalian AT1 and AT2 receptors .
9571644	0	angiotensin_II	22,36	AT1	10,13	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY subtype|dobj|receptors subtype|nsubj|Action Action|nmod|END_ENTITY	Action of AT1 subtype angiotensin_II receptors of the medial preoptic area on gonadotropins and prolactin release .
9655647	0	angiotensin_II	47,61	AT1	63,66	angiotensin II	AT1	185	185	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Molecular and cellular mechanisms of action of angiotensin_II -LRB- AT1 -RRB- receptors in vascular smooth muscle .
9664623	0	angiotensin_II	79,93	AT1	31,34	angiotensin II	AT1	183	185	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|affinity affinity|compound|END_ENTITY	Effect of uncoupling agents on AT1 receptor affinity for antagonist analogs of angiotensin_II .
9711980	0	angiotensin_II	47,61	AT1	78,81	angiotensin II	AT1	183	185	Gene	Gene	vasopressin|nmod|START_ENTITY mediated|nsubjpass|vasopressin mediated|nmod|subtype subtype|compound|END_ENTITY	Arginine vasopressin and oxytocin responses to angiotensin_II are mediated by AT1 receptor subtype in normal men .
9730777	0	angiotensin_II	34,48	AT1	102,105	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY isolated|nsubj|effects isolated|dobj|kidney kidney|dep|influence influence|nmod|END_ENTITY	Vascular and excretory effects of angiotensin_II in the rat isolated perfused kidney : influence of an AT1 and a nonselective AT receptor antagonist .
9731195	0	angiotensin_II	101,115	AT1	73,76	angiotensin II	AT1	183	185	Gene	Gene	active|nmod|START_ENTITY active|nmod|associate associate|nmod|receptor receptor|compound|END_ENTITY	Janus_kinase_2 -LRB- Jak2 -RRB- must be catalytically active to associate with the AT1 receptor in response to angiotensin_II .
9876309	0	angiotensin_II	29,43	AT1	67,70	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY hyperglycemia|acl|induced mediated|nsubjpass|hyperglycemia mediated|nmod|receptors receptors|nummod|END_ENTITY	The hyperglycemia induced by angiotensin_II in rats is mediated by AT1 receptors .
9878793	0	angiotensin_II	44,58	AT1	75,78	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	infusion|nmod|START_ENTITY increases|nsubj|infusion increases|dobj|expression expression|nummod|END_ENTITY	Chronic intracerebroventricular infusion of angiotensin_II increases brain AT1 receptor expression in young rats .
9932287	0	angiotensin_II	36,50	AT1	62,65	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Immunohistochemical localization of angiotensin_II receptors -LRB- AT1 -RRB- in the heart with anti-peptide antibodies showing a positive chronotropic effect .
9950790	0	angiotensin_II	70,84	AT1	41,44	angiotensin II	AT1	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	proliferation|nmod|START_ENTITY proliferation|nmod|receptors receptors|nummod|END_ENTITY	Control of adrenal cell proliferation by AT1 receptors in response to angiotensin_II and low-sodium diet .
16332920	0	angiotensin_II	110,124	AT1A	4,8	angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	active|nmod|START_ENTITY active|nsubj|receptor receptor|compound|END_ENTITY	The AT1A receptor `` gain-of-function '' mutant N111S/delta329 is both constitutively active and hyperreactive to angiotensin_II .
25542758	0	angiotensin_II	42,56	AT1A	57,61	angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Clathrin-dependent internalization of the angiotensin_II AT1A receptor links receptor internalization to COX-2 protein expression in rat aortic vascular smooth muscle cells .
25542758	0	angiotensin_II	42,56	AT1A	57,61	angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Clathrin-dependent internalization of the angiotensin_II AT1A receptor links receptor internalization to COX-2 protein expression in rat aortic vascular smooth muscle cells .
8484752	0	angiotensin_II	49,63	AT1A	35,39	angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Comparison of COS cell transfected AT1A and AT1B angiotensin_II receptors and angiotensin_II receptor isoforms in rat tissues using isoelectric focusing .
8584237	0	angiotensin_II	18,32	AT1A	34,38	angiotensin II	AT1A	183	24180(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The effect of the angiotensin_II -LRB- AT1A -RRB- receptor stably transfected into human neuroblastoma SH-SY5Y cells on noradrenaline release and changes in intracellular calcium .
8609915	0	angiotensin_II	19,33	AT1A	72,76	Angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	cAMP|nmod|START_ENTITY role|nmod|cAMP mediated|nsubj|role mediated|nmod|cells cells|nummod|END_ENTITY	A role for cAMP in angiotensin_II mediated inhibition of cell growth in AT1A receptor-transfected CHO-K1 cells .
8760087	0	angiotensin_II	28,42	AT1A	14,18	angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	RNA|compound|START_ENTITY RNA|compound|END_ENTITY	Expression of AT1A and AT1B angiotensin_II receptor messenger RNA in forebrain of 2-wk-old rats .
8925869	0	angiotensin_II	70,84	AT1A	86,90	angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Evidence against a role for protein kinase C in the regulation of the angiotensin_II -LRB- AT1A -RRB- receptor .
8945996	0	angiotensin_II	11,25	AT1A	91,95	angiotensin II	AT1A	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY mediated|nsubjpass|Effects mediated|nmod|receptors receptors|nummod|END_ENTITY	Effects of angiotensin_II on cultured rat renomedullary interstitial cells are mediated by AT1A receptors .
20458733	0	angiotensin_II	15,29	AT1R	47,51	angiotensin II	AT1R	183	185	Gene	Gene	receptor|amod|START_ENTITY signaling|compound|receptor signaling|appos|END_ENTITY	Angiotensin_II / angiotensin_II type I receptor -LRB- AT1R -RRB- signaling promotes MCF-7 breast_cancer cells survival via PI3-kinase/Akt pathway .
10222259	0	angiotensin_II	21,35	AT1_receptor	78,90	angiotensin II	AT1 receptor	11606(Tax:10090)	11610(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY exaggerated|nsubj|response exaggerated|nmod|upregulation upregulation|nmod|END_ENTITY	Vascular response to angiotensin_II is exaggerated through an upregulation of AT1_receptor in AT2 knockout mice .
15117826	0	angiotensin_II	99,113	AT1_receptor	114,126	angiotensin II	AT1 receptor	11606(Tax:10090)	11610(Tax:10090)	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Chronic production of angiotensin_IV in the brain leads to hypertension that is reversible with an angiotensin_II AT1_receptor antagonist .
16141358	0	angiotensin_II	94,108	AT1_receptor	12,24	angiotensin II	AT1 receptor	183	185	Gene	Gene	actions|nmod|START_ENTITY mediating|dobj|actions pathways|xcomp|mediating pathways|nsubj|END_ENTITY	Pleiotropic AT1_receptor signaling pathways mediating physiological and pathogenic actions of angiotensin_II .
8158154	0	angiotensin_II	117,131	AT1_receptor	42,54	angiotensin II	AT1 receptor	24179(Tax:10116)	11610(Tax:10090)	Gene	Gene	actions|nmod|START_ENTITY inhibits|dobj|actions inhibits|nsubj|administration administration|nmod|oligonucleotides oligonucleotides|amod|END_ENTITY	Intracerebroventricular administration of AT1_receptor antisense oligonucleotides inhibits the behavioral actions of angiotensin_II .
14517903	0	angiotensin_II	78,92	AT1a	102,106	angiotensin II	AT1a	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	fragment|nmod|START_ENTITY angiotensin_II|nmod|fragment END_ENTITY|amod|angiotensin_II	Interaction of angiotensin_II with the C-terminal 300-320 fragment of the rat angiotensin_II receptor AT1a monitored by NMR .
24740791	0	angiotensin_II	47,61	AT1a	14,18	angiotensin II	AT1a	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	uptake|nmod|START_ENTITY uptake|amod|END_ENTITY	Mechanisms of AT1a receptor-mediated uptake of angiotensin_II by proximal tubule cells : a novel role of the multiligand endocytic receptor megalin .
10222259	0	angiotensin_II	21,35	AT2	94,97	angiotensin II	AT2	11606(Tax:10090)	20726(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY exaggerated|nsubj|response exaggerated|nmod|upregulation upregulation|nmod|AT1_receptor AT1_receptor|nmod|mice mice|compound|END_ENTITY	Vascular response to angiotensin_II is exaggerated through an upregulation of AT1_receptor in AT2 knockout mice .
10652498	0	angiotensin_II	29,43	AT2	44,47	angiotensin II	AT2	186	186	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Signal transduction from the angiotensin_II AT2 receptor .
11384773	0	angiotensin_II	118,132	AT2	29,32	angiotensin II	AT2	183	186	Gene	Gene	infusions|nmod|START_ENTITY given|dobj|infusions given|nsubj|down-regulation down-regulation|nmod|receptors receptors|nummod|END_ENTITY	Selective down-regulation of AT2 receptors in uterine arteries from pregnant ewes given 24-h intravenous infusions of angiotensin_II .
1330640	0	angiotensin_II	45,59	AT2	61,64	angiotensin II	AT2	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Characterization of biochemical responses of angiotensin_II -LRB- AT2 -RRB- binding sites in the rat pheochromocytoma PC12W cells .
1437716	0	angiotensin_II	14,28	AT2	29,32	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of angiotensin_II AT2 receptors in the rat skin during experimental wound healing .
14530222	0	angiotensin_II	19,33	AT2	34,37	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Functional role of angiotensin_II AT2 receptor in modulation of AT1 receptor-mediated contraction in rat uterine artery : involvement of bradykinin and nitric_oxide .
15485557	0	angiotensin_II	49,63	AT2	14,17	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	properties|nmod|START_ENTITY properties|nummod|END_ENTITY	Synthesis and AT2 receptor-binding properties of angiotensin_II analogues .
1639112	0	angiotensin_II	23,37	AT2	4,7	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY subtype|nmod|receptors subtype|compound|END_ENTITY	The AT2 subtype of the angiotensin_II receptors has differential sensitivity to dithiothreitol in specific brain nuclei of young rats .
17068200	0	angiotensin_II	50,64	AT2	130,133	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	type|compound|START_ENTITY differentiation|nmod|type differentiation|dep|cascade cascade|nmod|interaction interaction|nmod|protein protein|nummod|END_ENTITY	Angiotensin_II-induced neural differentiation via angiotensin_II type 2 -LRB- AT2 -RRB- receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src_homology_2_domain-containing_protein-tyrosine_phosphatase_1 .
17068200	0	angiotensin_II	50,64	AT2	73,76	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	type|compound|START_ENTITY differentiation|nmod|type differentiation|appos|END_ENTITY	Angiotensin_II-induced neural differentiation via angiotensin_II type 2 -LRB- AT2 -RRB- receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src_homology_2_domain-containing_protein-tyrosine_phosphatase_1 .
17125268	0	angiotensin_II	10,24	AT2	25,28	angiotensin II	AT2	183	186	Gene	Gene	agonists|compound|START_ENTITY agonists|compound|END_ENTITY	Selective angiotensin_II AT2 receptor agonists : arylbenzylimidazole structure-activity relationships .
18511032	0	angiotensin_II	11,25	AT2	139,142	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|parataxis|angiotensin_III angiotensin_III|nsubj|receptor receptor|nummod|END_ENTITY	Effects of angiotensin_II and its metabolites in the rat coronary vascular bed : is angiotensin_III the preferred ligand of the angiotensin AT2 receptor ?
1887916	0	angiotensin_II	24,38	AT2	20,23	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|nummod|END_ENTITY	Characterization of AT2 angiotensin_II receptors in rat anterior cerebral arteries .
19353416	0	angiotensin_II	77,91	AT2	98,101	angiotensin II	AT2	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|appos|AT1 AT1|dep|END_ENTITY	Increased perfusion pressure enhances the expression of endothelin -LRB- ETB -RRB- and angiotensin_II -LRB- AT1 , AT2 -RRB- receptors in rat mesenteric artery smooth muscle cells .
25170617	0	angiotensin_II	84,98	AT2	32,35	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	decreases|nmod|START_ENTITY decreases|nsubj|Upregulation Upregulation|nmod|ERK1/2-eNOS ERK1/2-eNOS|nmod|receptors receptors|nummod|END_ENTITY	Upregulation of ERK1/2-eNOS via AT2 receptors decreases the contractile response to angiotensin_II in resistance mesenteric arteries from obese rats .
7507323	0	angiotensin_II	43,57	AT2	113,116	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|nmod|receptor receptor|appos|END_ENTITY	Protein tyrosine phosphatase inhibition by angiotensin_II in rat pheochromocytoma cells through type 2 receptor , AT2 .
8143746	0	angiotensin_II	104,118	AT2	100,103	angiotensin II	AT2	183	186	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Characterization of a membrane glycoprotein having pharmacological and biochemical properties of an AT2 angiotensin_II receptor from human myometrium .
8258820	0	angiotensin_II	55,69	AT2	85,88	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	inhibitors|nmod|START_ENTITY series|nmod|inhibitors series|amod|binding binding|nmod|site site|compound|END_ENTITY	A novel series of selective , non-peptide inhibitors of angiotensin_II binding to the AT2 site .
8311944	0	angiotensin_II	62,76	AT2	27,30	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The effect of the putative AT2 agonist , p-aminophenylalanine6 angiotensin_II , on thirst and sodium_appetite in rats .
8453029	0	angiotensin_II	26,40	AT2	41,44	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Characterization of brain angiotensin_II AT2 receptor subtype using -LSB- 125I -RSB- CGP_42112A .
8469774	0	angiotensin_II	24,38	AT2	40,43	angiotensin II	AT2	186	186	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulated expression of angiotensin_II -LRB- AT2 -RRB- binding sites in R3T3 cells .
9521484	0	angiotensin_II	79,93	AT2	8,11	angiotensin II	AT2	24179(Tax:10116)	24182(Tax:10116)	Gene	Gene	microinjection|nmod|START_ENTITY events|nmod|microinjection receptors|nmod|events receptors|nummod|END_ENTITY	Role of AT2 receptors in the cardiovascular events following microinjection of angiotensin_II into the superior colliculus of anaesthetised rats .
9570482	0	angiotensin_II	46,60	AT2	80,83	angiotensin II	AT2	183	186	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	N - and C-terminal structure-activity study of angiotensin_II on the angiotensin AT2 receptor .
9773120	0	angiotensin_II	31,45	AT2	14,17	angiotensin II	AT2	183	186	Gene	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	-LSB- Functions of AT2 receptors of angiotensin_II -RSB- .
9826555	0	angiotensin_II	81,95	AT2	64,67	angiotensin II	AT2	183	186	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Modulation of the vascular smooth muscle angiotensin subtype 2 -LRB- AT2 -RRB- receptor by angiotensin_II .
18789946	0	angiotensin_II	23,37	AUF1	0,4	angiotensin II	AUF1	183	3184	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	AUF1 is upregulated by angiotensin_II to destabilize cardiac Kv4 .3 channel mRNA .
24412389	0	angiotensin_II	109,123	A_disintegrin_and_metalloproteinase_17	0,38	angiotensin II	A disintegrin and metalloproteinase 17	183	6868	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	A_disintegrin_and_metalloproteinase_17 -LRB- ADAM17 -RRB- mediates epidermal_growth_factor_receptor transactivation by angiotensin_II on hepatic stellate cells .
14751847	0	angiotensin_II	60,74	Adrenomedullin	0,14	angiotensin II	Adrenomedullin	24179(Tax:10116)	25026(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY modulates|dobj|effects modulates|nsubj|END_ENTITY	Adrenomedullin modulates hemodynamic and cardiac effects of angiotensin_II in conscious rats .
12623995	0	angiotensin_II	47,61	Akt	16,19	angiotensin II	Akt	183	207	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|compound|END_ENTITY	Insulin-induced Akt activation is inhibited by angiotensin_II in the vasculature through protein_kinase_C-alpha .
15849355	0	angiotensin_II	21,35	Akt	74,77	angiotensin II	Akt	24179(Tax:10116)	24185(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Resveratrol inhibits angiotensin_II - and epidermal_growth_factor-mediated Akt activation : role of Gab1 and Shp2 .
21071431	0	angiotensin_II	37,51	Akt	19,22	angiotensin II	Akt	24179(Tax:10116)	24185(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|compound|END_ENTITY	Resveratrol blocks Akt activation in angiotensin_II - or EGF-stimulated vascular smooth muscle cells in a redox-independent manner .
8833654	0	angiotensin_II	35,49	Angiotensinogen	0,15	angiotensin II	Angiotensinogen	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
2524525	0	angiotensin_II	41,55	Atrial_natriuretic_factor	0,25	angiotensin II	Atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	infusion|amod|START_ENTITY release|nmod|infusion release|nsubj|END_ENTITY	Atrial_natriuretic_factor release during angiotensin_II infusion in right and left atrial appendectomized rats .
2952590	0	angiotensin_II	43,57	Atrial_natriuretic_factor	0,25	angiotensin II	Atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	responses|amod|START_ENTITY inhibits|dobj|responses inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits central angiotensin_II pressor responses .
2968308	0	angiotensin_II	37,51	Atrial_natriuretic_factor	0,25	angiotensin II	Atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Atrial_natriuretic_factor release by angiotensin_II in the conscious rat .
2977176	0	angiotensin_II	98,112	Atrial_natriuretic_factor	0,25	angiotensin II	Atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	action|nmod|START_ENTITY heart|nmod|action protects|dobj|heart protects|nsubj|END_ENTITY	Atrial_natriuretic_factor protects the isolated working ischaemic rat heart against the action of angiotensin_II .
6092045	0	angiotensin_II	79,93	Atrial_natriuretic_factor	0,25	angiotensin II	Atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY stimulation|nmod|secretion inhibits|dobj|stimulation inhibits|nsubj|END_ENTITY	Atrial_natriuretic_factor inhibits the stimulation of aldosterone secretion by angiotensin_II , ACTH and potassium in vitro and angiotensin_II-induced steroidogenesis in vivo .
2948755	0	angiotensin_II	61,75	Atrial_natriuretic_peptide	0,26	angiotensin II	Atrial natriuretic peptide	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits the effect of endogenous angiotensin_II on plasma aldosterone in conscious sodium-depleted rats .
9387850	0	angiotensin_II	75,89	Atrial_natriuretic_peptide	0,26	angiotensin II	Atrial natriuretic peptide	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY modulates|dobj|effects modulates|nsubj|END_ENTITY	Atrial_natriuretic_peptide negatively modulates the stimulatory effects of angiotensin_II on tuberoinfundibular dopaminergic neuronal activity .
16950177	0	angiotensin_II	108,122	C-reactive_protein	11,29	angiotensin II	C-reactive protein	183	1401	Gene	Gene	vitro|nmod|START_ENTITY grafting|amod|vitro Effects|nmod|grafting Effects|nmod|END_ENTITY	Effects of C-reactive_protein and cholesterol on responsiveness in vitro of the internal thoracic artery to angiotensin_II in patients having coronary artery bypass grafting .
12844400	0	angiotensin_II	11,25	CD34	40,44	angiotensin II	CD34	183	947	Gene	Gene	expansion|amod|START_ENTITY expansion|compound|END_ENTITY	-LSB- Effect of angiotensin_II on cord blood CD34 -LRB- + -RRB- cells expansion in vitro -RSB- .
15934300	0	angiotensin_II	10,24	CD34	39,43	angiotensin II	CD34	183	947	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of angiotensin_II on cord blood CD34 + cells expansion in vitro .
16928312	0	angiotensin_II	11,25	CD34	69,73	angiotensin II	CD34	183	947	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	-LSB- Effect of angiotensin_II on differentiation of umbilical cord blood CD34 + cells into megakaryocytes -RSB- .
11501060	0	angiotensin_II	11,25	CRH	40,43	angiotensin II	CRH	24179(Tax:10116)	81648(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_II on release of CRH and AVP from hypothalamus during acute hypoxia .
12105167	0	angiotensin_II	99,113	CYR61	14,19	angiotensin II	CYR61	183	3491	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CYR61 , an angiogenic immediate early gene , in arteriosclerosis and its regulation by angiotensin_II .
3628548	0	angiotensin_II	91,105	Calcitonin	0,10	angiotensin II	Calcitonin	24179(Tax:10116)	24241(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Calcitonin effect on the dipsogenic response to intra-cerebroventricular administration of angiotensin_II .
21172357	0	angiotensin_II	112,126	Caveolin-1	0,10	angiotensin II	Caveolin-1	183	857	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Caveolin-1 negatively regulates a metalloprotease-dependent epidermal_growth_factor_receptor transactivation by angiotensin_II .
24329494	0	angiotensin_II	74,88	Caveolin_1	0,10	angiotensin II	Caveolin 1	11606(Tax:10090)	12389(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY formation|acl|induced critical|nmod|formation critical|nsubj|END_ENTITY	Caveolin_1 is critical for abdominal_aortic_aneurysm formation induced by angiotensin_II and inhibition of lysyl oxidase .
25979571	0	angiotensin_II	91,105	Cdkn1c	73,79	angiotensin II	Cdkn1c	24179(Tax:10116)	246060(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Losartan reverses the down-expression of long noncoding RNA-NR024118 and Cdkn1c induced by angiotensin_II in adult rat cardiac fibroblasts .
19106112	0	angiotensin_II	58,72	Coupling_factor_6	0,17	angiotensin II	Coupling factor 6	24179(Tax:10116)	11957(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Coupling_factor_6 enhances Src-mediated responsiveness to angiotensin_II in resistance arterioles and cells .
20563831	0	angiotensin_II	32,46	EMMPRIN	98,105	angiotensin II	EMMPRIN	183	682	Gene	Gene	START_ENTITY|nmod|extracellular_matrix_metalloproteinase_inducer extracellular_matrix_metalloproteinase_inducer|appos|END_ENTITY	The effect of the expression of angiotensin_II on extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- in macrophages is mediated via the AT1/COX -2 / PGE2 pathway .
14755545	0	angiotensin_II	130,144	ERK1/2	0,6	angiotensin II	ERK1/2	24179(Tax:10116)	50689;116590	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	ERK1/2 and JNKs , but not p38 kinase , are involved in reactive oxygen species-mediated induction of osteopontin gene expression by angiotensin_II and interleukin-1beta in adult rat cardiac fibroblasts .
15775784	0	angiotensin_II	137,151	ERK1/2	112,118	angiotensin II	ERK1/2	183	5595;5594	Gene	Gene	role|nmod|START_ENTITY role|nmod|responsiveness responsiveness|nummod|END_ENTITY	Angiotensin_II-induced over-activation of p47phox in fibroblasts from hypertensives : which role in the enhanced ERK1/2 responsiveness to angiotensin_II ?
15921682	0	angiotensin_II	21,35	ERK1/2	0,6	angiotensin II	ERK1/2	24179(Tax:10116)	50689;116590	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	ERK1/2 activation by angiotensin_II inhibits insulin-induced glucose uptake in vascular smooth muscle cells .
17763940	0	angiotensin_II	56,70	ERK1/2	115,121	angiotensin II	ERK1/2	24179(Tax:10116)	50689;116590	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|kinases kinases|compound|END_ENTITY	Regulation of c-fos , c-jun and c-myc gene expression by angiotensin_II in primary cultured rat astrocytes : role of ERK1/2 MAP kinases .
17952409	0	angiotensin_II	14,28	ERK1/2	39,45	angiotensin II	ERK1/2	24179(Tax:10116)	50689;116590	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of angiotensin_II and IV on ERK1/2 and CREB signalling in cultured rat astroglial cells .
18083124	0	angiotensin_II	50,64	ERK1/2	21,27	angiotensin II	ERK1/2	183	5595;5594	Gene	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|nummod|END_ENTITY	Roscovitine inhibits ERK1/2 activation induced by angiotensin_II in vascular smooth muscle cells .
19041135	0	angiotensin_II	27,41	ERK1/2	69,75	angiotensin II	ERK1/2	11606(Tax:10090)	26417;26413	Gene	Gene	START_ENTITY|acl|induced induced|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Angiotensin - -LRB- 1-7 -RRB- enhances angiotensin_II induced phosphorylation of ERK1/2 in mouse bone marrow-derived dendritic cells .
9045626	0	angiotensin_II	31,45	ERK1/2	60,66	angiotensin II	ERK1/2	24179(Tax:10116)	50689;116590	Gene	Gene	START_ENTITY|dobj|activation activation|nmod|END_ENTITY	Protein_kinase_C-zeta mediates angiotensin_II activation of ERK1/2 in vascular smooth muscle cells .
9440699	0	angiotensin_II	65,79	ERK1/2	54,60	angiotensin II	ERK1/2	11606(Tax:10090)	26417;26413	Gene	Gene	kinases|nmod|START_ENTITY kinases|appos|END_ENTITY	Activation of extracellular signal-regulated kinases -LRB- ERK1/2 -RRB- by angiotensin_II is dependent on c-Src in vascular smooth muscle cells .
1516947	0	angiotensin_II	42,56	Endothelin-1	0,12	angiotensin II	Endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	infusion|amod|START_ENTITY augments|nmod|infusion augments|nsubj|END_ENTITY	Endothelin-1 augments pressor response to angiotensin_II infusion in rats .
19139972	0	angiotensin_II	23,37	Endothelin-1	0,12	angiotensin II	Endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Endothelin-1 modulates angiotensin_II in the development of hypertension in fructose-fed rats .
24041954	0	angiotensin_II	77,91	Endothelin-1	0,12	angiotensin II	Endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY mechanisms|nmod|receptor autoantibody-enhanced|nsubj|mechanisms END_ENTITY|parataxis|autoantibody-enhanced	Endothelin-1 , oxidative stress , and endogenous angiotensin_II : mechanisms of angiotensin_II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy .
9595499	0	angiotensin_II	81,95	Endothelin-1	0,12	angiotensin II	Endothelin-1	11606(Tax:10090)	13614(Tax:10090)	Gene	Gene	hearts|nmod|START_ENTITY expression|nmod|hearts expression|amod|END_ENTITY	Endothelin-1 expression in hearts of transgenic_hypertensive_mice overexpressing angiotensin_II .
11304462	0	angiotensin_II	52,66	Epidermal_growth_factor_receptor	0,32	angiotensin II	Epidermal growth factor receptor	183	1956	Gene	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	Epidermal_growth_factor_receptor transactivation by angiotensin_II requires reactive oxygen species in vascular smooth muscle cells .
11239021	0	angiotensin_II	25,39	Erythropoietin	0,14	angiotensin II	Erythropoietin	24179(Tax:10116)	24335(Tax:10116)	Gene	Gene	mobilization|amod|START_ENTITY modulates|dobj|mobilization modulates|nsubj|END_ENTITY	Erythropoietin modulates angiotensin_II - or noradrenaline-induced Ca -LRB- 2 + -RRB- mobilization in cultured rat vascular smooth-muscle cells .
19100095	0	angiotensin_II	107,121	Erythropoietin	1,15	angiotensin II	Erythropoietin	24179(Tax:10116)	24335(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- fibroblasts|acl|induced suppresses|nmod|fibroblasts suppresses|nsubj|END_ENTITY	-LSB- Erythropoietin suppresses the expressions of TGF-beta1 and collagen in rat cardiac fibroblasts induced by angiotensin_II -RSB- .
19781221	0	angiotensin_II	25,39	Erythropoietin	1,15	angiotensin II	Erythropoietin	24179(Tax:10116)	24335(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	-LSB- Erythropoietin inhibits angiotensin_II induced cardiomyocyte hypertrophy in vitro via activating PI3K/Akt-eNOS pathway -RSB- .
11463773	0	angiotensin_II	28,42	Fos	47,50	angiotensin II	Fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Inhibition of baroreflex by angiotensin_II via Fos expression in nucleus tractus solitarii of the rat .
7796121	0	angiotensin_II	59,73	Fos	0,3	angiotensin II	Fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Fos induced in brain of spontaneously hypertensive rats by angiotensin_II and co-localization with AT-1 receptors .
11228750	0	angiotensin_II	14,28	GATA4	43,48	angiotensin II	GATA4	183	2626	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Modulation of angiotensin_II signaling for GATA4 activation by homocysteine .
22558183	0	angiotensin_II	122,136	GATA4	53,58	angiotensin II	GATA4	11606(Tax:10090)	14463(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY signaling|nmod|receptor hypertrophic|acl|signaling hypertrophic|nummod|END_ENTITY	Promyelocytic_leukemia_zinc_finger_protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin_II receptor 2 .
9657355	0	angiotensin_II	38,52	GH	24,26	angiotensin II	GH	183	2688	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Stimulation of ACTH and GH release by angiotensin_II in normal men is mediated by the AT1 receptor subtype .
14523024	0	angiotensin_II	66,80	GIT1	0,4	angiotensin II	GIT1	183	28964	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin_II and epidermal growth factor .
14701758	0	angiotensin_II	98,112	GIT1	0,4	angiotensin II	GIT1	183	28964	Gene	Gene	signal-regulated|nmod|START_ENTITY signal-regulated|nsubj|functions functions|nummod|END_ENTITY	GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin_II and epidermal_growth_factor .
18292392	0	angiotensin_II	34,48	GIT1	0,4	angiotensin II	GIT1	183	28964	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	GIT1 mediates HDAC5 activation by angiotensin_II in vascular smooth muscle cells .
18292392	0	angiotensin_II	34,48	HDAC5	14,19	angiotensin II	HDAC5	183	10014	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	GIT1 mediates HDAC5 activation by angiotensin_II in vascular smooth muscle cells .
9403566	0	angiotensin_II	8,22	HGF	98,101	angiotensin II	HGF	24179(Tax:10116)	24446(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of angiotensin_II in the regulation of a novel vascular modulator , hepatocyte_growth_factor -LRB- HGF -RRB- , in experimental hypertensive rats .
9740609	0	angiotensin_II	68,82	HGF	155,158	angiotensin II	HGF	24179(Tax:10116)	24446(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Negative regulation of local hepatocyte_growth_factor expression by angiotensin_II and transforming growth factor-beta in blood vessels : potential role of HGF in cardiovascular_disease .
10924066	0	angiotensin_II	90,104	Heme_oxygenase-1	0,16	angiotensin II	Heme oxygenase-1	24179(Tax:10116)	24451(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY upregulated|nmod|administration upregulated|nsubjpass|END_ENTITY	Heme_oxygenase-1 is upregulated in the rat heart in response to chronic administration of angiotensin_II .
16181103	0	angiotensin_II	94,108	Heme_oxygenase-1	0,16	angiotensin II	Heme oxygenase-1	11606(Tax:10090)	15368(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY cardiovascular_damage|acl|induced counteracts|dobj|cardiovascular_damage counteracts|nsubj|END_ENTITY	Heme_oxygenase-1 in vascular smooth muscle cells counteracts cardiovascular_damage induced by angiotensin_II .
18174886	0	angiotensin_II	67,81	Heme_oxygenase-1	0,16	angiotensin II	Heme oxygenase-1	11606(Tax:10090)	15368(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY improve|nmod|mice improve|nsubj|induction induction|amod|END_ENTITY	Heme_oxygenase-1 induction does not improve vascular relaxation in angiotensin_II hypertensive mice .
18515325	0	angiotensin_II	49,63	Heme_oxygenase-1	0,16	angiotensin II	Heme oxygenase-1	183	3162	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|expression expression|amod|END_ENTITY	Heme_oxygenase-1 expression is down-regulated by angiotensin_II and under hypertension in human neutrophils .
9052897	0	angiotensin_II	33,47	Heme_oxygenase-1	0,16	angiotensin II	Heme oxygenase-1	24179(Tax:10116)	24451(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Heme_oxygenase-1 is regulated by angiotensin_II in rat vascular smooth muscle cells .
20926686	0	angiotensin_II	70,84	Hepatocyte_growth_factor	0,24	angiotensin II	Hepatocyte growth factor	24179(Tax:10116)	24446(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Hepatocyte_growth_factor inhibits apoptosis by the profibrotic factor angiotensin_II via extracellular_signal-regulated_kinase_1 / 2 in endothelial cells and tissue explants .
25653183	0	angiotensin_II	40,54	HuR	0,3	angiotensin II	HuR	11606(Tax:10090)	15568(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	HuR mediates the synergistic effects of angiotensin_II and IL-1b on vascular COX-2 expression and cell migration .
11597988	0	angiotensin_II	118,132	IL-6	110,114	angiotensin II	IL-6	183	3569	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|induction induction|nmod|END_ENTITY	ERK and p38 MAPK , but not NF-kappaB , are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin_II in cardiac fibroblasts .
21393356	0	angiotensin_II	94,108	IL-6	57,61	angiotensin II	IL-6	183	3569	Gene	Gene	response|nmod|START_ENTITY produce|nmod|response produce|dobj|END_ENTITY	Highly purified human peripheral blood monocytes produce IL-6 but not TNFalpha in response to angiotensin_II .
26486161	0	angiotensin_II	82,96	IL-6	12,16	angiotensin II	IL-6	11606(Tax:10090)	16193(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of IL-6 in the physiologic versus hypertensive blood pressure actions of angiotensin_II .
23775122	0	angiotensin_II	50,64	IRS2	32,36	angiotensin II	IRS2	24179(Tax:10116)	29376(Tax:10116)	Gene	Gene	activated|nmod|START_ENTITY END_ENTITY|acl|activated	Serine phosphorylation sites on IRS2 activated by angiotensin_II and protein kinase C to induce selective insulin resistance in endothelial cells .
9258403	0	angiotensin_II	46,60	Interleukin-2	0,13	angiotensin II	Interleukin-2	183	3558	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Interleukin-2 modulates the responsiveness to angiotensin_II in cultured vascular smooth muscle cells .
12054679	0	angiotensin_II	51,65	JNK	88,91	angiotensin II	JNK	24179(Tax:10116)	116554(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Quercetin glucuronide prevents VSMC hypertrophy by angiotensin_II via the inhibition of JNK and AP-1 signaling pathway .
11818507	0	angiotensin_II	68,82	Janus_kinase_2	39,53	angiotensin II	Janus kinase 2	183	3717	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Requirement of Ca -LRB- 2 + -RRB- and PKCdelta for Janus_kinase_2 activation by angiotensin_II : involvement of PYK2 .
9731195	0	angiotensin_II	101,115	Janus_kinase_2	0,14	angiotensin II	Janus kinase 2	183	3717	Gene	Gene	active|nmod|START_ENTITY active|nsubj|END_ENTITY	Janus_kinase_2 -LRB- Jak2 -RRB- must be catalytically active to associate with the AT1 receptor in response to angiotensin_II .
20833961	0	angiotensin_II	34,48	Kinin_B1_receptor	0,17	angiotensin II	Kinin B1 receptor	24179(Tax:10116)	81509(Tax:10116)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Kinin_B1_receptor upregulation by angiotensin_II and endothelin-1 in rat vascular smooth muscle cells : receptors and mechanisms .
19126408	0	angiotensin_II	83,97	LOX-1	0,5	angiotensin II	LOX-1	11606(Tax:10090)	108078(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|compound|END_ENTITY	LOX-1 dependent overexpression of immunoglobulins in cardiomyocytes in response to angiotensin_II .
25005756	0	angiotensin_II	57,71	LOX-1	0,5	angiotensin II	LOX-1	11606(Tax:10090)	108078(Tax:10090)	Gene	Gene	given|dobj|START_ENTITY mice|acl|given limits|nmod|mice limits|nsubj|deletion deletion|compound|END_ENTITY	LOX-1 deletion limits cardiac angiogenesis in mice given angiotensin_II .
16144973	0	angiotensin_II	63,77	Leptin	0,6	angiotensin II	Leptin	24179(Tax:10116)	25608(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Leptin induces vascular smooth muscle cell hypertrophy through angiotensin_II - and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy .
20592755	0	angiotensin_II	77,91	Leptin	0,6	angiotensin II	Leptin	24179(Tax:10116)	25608(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY cells|acl|induced proliferation|nmod|cells inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	Leptin inhibits the proliferation of vascular smooth muscle cells induced by angiotensin_II through nitric_oxide-dependent mechanisms .
17487826	0	angiotensin_II	65,79	MCP-2	104,109	angiotensin II	MCP-2	183	6355	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|parataxis|induces induces|dobj|END_ENTITY	Changes of gene expression profiles in macrophages stimulated by angiotensin_II -- angiotensin_II induces MCP-2 through AT1-receptor .
17487826	0	angiotensin_II	81,95	MCP-2	104,109	angiotensin II	MCP-2	183	6355	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Changes of gene expression profiles in macrophages stimulated by angiotensin_II -- angiotensin_II induces MCP-2 through AT1-receptor .
21641389	0	angiotensin_II	101,115	MMP-2	23,28	angiotensin II	MMP-2	183	4313	Gene	Gene	type|amod|START_ENTITY mediated|nmod|type mediated|nsubjpass|activity activity|compound|END_ENTITY	Angiotensin_II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin_II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal_pigment_epithelium : implications for age-related_macular_degeneration .
25867313	0	angiotensin_II	11,25	MMP-2	42,47	angiotensin II	MMP-2	24179(Tax:10116)	81686(Tax:10116)	Gene	Gene	intervention|amod|START_ENTITY Effects|nmod|intervention Effects|nmod|TIMP-1 TIMP-1|compound|END_ENTITY	Effects of angiotensin_II intervention on MMP-2 , MMP-9 , TIMP-1 , and collagen expression in rats with pulmonary_hypertension .
19233360	0	angiotensin_II	32,46	MMP8	14,18	angiotensin II	MMP8	183	4317	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of MMP8 and MMP13 by angiotensin_II correlates to severe intra-plaque_hemorrhages and collagen breakdown in atherosclerotic_lesions with a vulnerable phenotype .
25446178	0	angiotensin_II	28,42	MRTF-A	12,18	angiotensin II	MRTF-A	11606(Tax:10090)	223701(Tax:10090)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Endothelial MRTF-A mediates angiotensin_II induced cardiac_hypertrophy .
15467006	0	angiotensin_II	31,45	Megalin	0,7	angiotensin II	Megalin	183	4036	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Megalin binds and internalizes angiotensin_II .
11940383	0	angiotensin_II	64,78	NF-kappaB	10,19	angiotensin II	NF-kappaB	183	4790	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Effect Effect|nmod|END_ENTITY	Effect of NF-kappaB on the induction of PDGF-B transcription by angiotensin_II in the ECV304 cell line .
15802625	0	angiotensin_II	39,53	NF-kappaB	68,77	angiotensin II	NF-kappaB	183	4790	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	A new cellular signaling mechanism for angiotensin_II activation of NF-kappaB : An IkappaB-independent , RSK-mediated phosphorylation of p65 .
11758217	0	angiotensin_II	107,121	NF-kappa_B	15,25	angiotensin II	NF-kappa B	183	4790	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Activation Activation|nmod|END_ENTITY	-LSB- Activation of NF-kappa_B and its effect on induction of platelet-derived growth factor-B transcription by angiotensin_II in ECV304 cell line -RSB- .
25928697	0	angiotensin_II	75,89	NFkB	104,108	angiotensin II	NFkB	24179(Tax:10116)	81736(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Skeletal muscle insulin resistance in salt-sensitive hypertension : role of angiotensin_II activation of NFkB .
9690205	0	angiotensin_II	33,47	NHE3	70,74	angiotensin II	NHE3	183	6550	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activation activation|nmod|END_ENTITY	Dominant negative c-Src inhibits angiotensin_II induced activation of NHE3 in OKP cells .
20339118	0	angiotensin_II	83,97	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5	0,61	angiotensin II	Nicotinamide adenine dinucleotide phosphate reduced oxidase 5	183	79400	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5 -LRB- Nox5 -RRB- regulation by angiotensin_II and endothelin-1 is mediated via calcium/calmodulin-dependent , rac-1-independent pathways in human endothelial cells .
20339118	0	angiotensin_II	83,97	Nox5	63,67	angiotensin II	Nox5	183	79400	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Nicotinamide_adenine_dinucleotide_phosphate_reduced_oxidase_5 -LRB- Nox5 -RRB- regulation by angiotensin_II and endothelin-1 is mediated via calcium/calmodulin-dependent , rac-1-independent pathways in human endothelial cells .
25657046	0	angiotensin_II	16,30	OxeR1	0,5	angiotensin II	OxeR1	183	165140	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	OxeR1 regulates angiotensin_II and cAMP-stimulated steroid production in human H295R adrenocortical cells .
20099714	0	angiotensin_II	59,73	P38_MAP_kinase	0,14	angiotensin II	P38 MAP kinase	183	1432	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	P38_MAP_kinase in valve interstitial cells is activated by angiotensin_II or nitric_oxide / peroxynitrite , but reduced by Toll-like_receptor-2 stimulation .
19940161	0	angiotensin_II	72,86	PGC-1_alpha	0,11	angiotensin II	PGC-1 alpha	183	10891	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	PGC-1_alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin_II drive catalase down-regulation and vascular hypertrophy .
11818507	0	angiotensin_II	68,82	PKCdelta	26,34	angiotensin II	PKCdelta	183	5580	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Requirement of Ca -LRB- 2 + -RRB- and PKCdelta for Janus_kinase_2 activation by angiotensin_II : involvement of PYK2 .
22198171	0	angiotensin_II	58,72	PTEN	92,96	angiotensin II	PTEN	24179(Tax:10116)	50557(Tax:10116)	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	Angiotensin - -LRB- 1-7 -RRB- attenuates the chronotropic response to angiotensin_II via stimulation of PTEN in the spontaneously hypertensive rat neurons .
22887358	0	angiotensin_II	46,60	PTEN	14,18	angiotensin II	PTEN	183	5728	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibition of PTEN expression and activity by angiotensin_II induces proliferation and migration of vascular smooth muscle cells .
9776731	0	angiotensin_II	82,96	PYK2	74,78	angiotensin II	PYK2	24179(Tax:10116)	50646(Tax:10116)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Calcium - and protein_kinase_C-dependent activation of the tyrosine kinase PYK2 by angiotensin_II in vascular smooth muscle .
9045626	0	angiotensin_II	31,45	Protein_kinase_C-zeta	0,21	angiotensin II	Protein kinase C-zeta	24179(Tax:10116)	25522(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Protein_kinase_C-zeta mediates angiotensin_II activation of ERK1/2 in vascular smooth muscle cells .
10722671	0	angiotensin_II	56,70	Pyk2	48,52	angiotensin II	Pyk2	183	2185	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Regulation of calcium-sensitive tyrosine kinase Pyk2 by angiotensin_II in endothelial cells .
10692485	0	angiotensin_II	45,59	RGS2	23,27	angiotensin II	RGS2	183	5997	Gene	Gene	RNA|nmod|START_ENTITY RNA|compound|END_ENTITY	Specific regulation of RGS2 messenger RNA by angiotensin_II in cultured vascular smooth muscle cells .
16627589	0	angiotensin_II	21,35	RGS2	0,4	angiotensin II	RGS2	183	5997	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	RGS2 is regulated by angiotensin_II and functions as a negative feedback of aldosterone production in H295R human adrenocortical cells .
16685212	0	angiotensin_II	158,172	RGS2	58,62	angiotensin II	RGS2	183	5997	Gene	Gene	induced|nmod|START_ENTITY mobilization|acl|induced increases|dobj|mobilization increases|nsubj|expression expression|nmod|regulator_of_G-protein_signaling_2 regulator_of_G-protein_signaling_2|appos|END_ENTITY	Reduced expression of regulator_of_G-protein_signaling_2 -LRB- RGS2 -RRB- in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin_II .
22057271	0	angiotensin_II	171,185	RGS2	136,140	angiotensin II	RGS2	183	5997	Gene	Gene	transcriptional|nmod|START_ENTITY transcriptional|nsubj|Identification Identification|nmod|element element|nmod|element element|nmod|END_ENTITY	Identification of a cAMP-response element in the regulator_of_G-protein_signaling-2 -LRB- RGS2 -RRB- promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin_II in cultured vascular smooth muscles .
22057271	0	angiotensin_II	171,185	RGS2	85,89	angiotensin II	RGS2	183	5997	Gene	Gene	transcriptional|nmod|START_ENTITY transcriptional|nsubj|Identification Identification|nmod|element element|nmod|promoter promoter|appos|END_ENTITY	Identification of a cAMP-response element in the regulator_of_G-protein_signaling-2 -LRB- RGS2 -RRB- promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin_II in cultured vascular smooth muscles .
17122362	0	angiotensin_II	41,55	Rac1	31,35	angiotensin II	Rac1	183	5879	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	Endogenous ARF6 interacts with Rac1 upon angiotensin_II stimulation to regulate membrane ruffling and cell migration .
9547018	0	angiotensin_II	11,25	Ren-2	100,105	angiotensin II	Ren-2	24179(Tax:10116)	19702(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cultures cultures|nmod|END_ENTITY	Endogenous angiotensin_II and cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic_rats .
19451703	0	angiotensin_II	104,118	Renin	0,5	angiotensin II	Renin	183	5972	Gene	Gene	production|amod|START_ENTITY cells|nmod|production implicated|nmod|cells pathways|acl|implicated activate|dobj|pathways activate|nsubj|END_ENTITY	Renin and prorenin activate pathways implicated in organ damage in human mesangial cells independent of angiotensin_II production .
2412013	0	angiotensin_II	57,71	Renin	0,5	angiotensin II	Renin	183	5972	Gene	Gene	role|nmod|START_ENTITY understanding|dobj|role use|acl|understanding inhibitors|dep|use inhibitors|compound|END_ENTITY	Renin inhibitors : their use in understanding the role of angiotensin_II as a pressor hormone .
3516662	0	angiotensin_II	41,55	Renin	0,5	angiotensin II	Renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	coexists|nmod|START_ENTITY coexists|nsubj|END_ENTITY	Renin in the rat pituitary coexists with angiotensin_II and depends on testosterone .
8385523	0	angiotensin_II	48,62	Renin	0,5	angiotensin II	Renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY losartan|appos|antagonist induced|nmod|losartan induced|nsubj|release release|compound|END_ENTITY	Renin release induced by losartan -LRB- DuP_753 -RRB- , an angiotensin_II receptor antagonist .
8829212	0	angiotensin_II	96,110	Renin	0,5	angiotensin II	Renin	183	5972	Gene	Gene	formation|amod|START_ENTITY independent|nmod|formation production|acl:relcl|independent stimulates|dobj|production stimulates|nsubj|END_ENTITY	Renin stimulates decidual prostaglandin production via a novel mechanism that is independent of angiotensin_II formation .
21173159	0	angiotensin_II	113,127	RhoA	98,102	angiotensin II	RhoA	183	387	Gene	Gene	type|amod|START_ENTITY END_ENTITY|nmod|type	b-Arrestin_1 inhibits the GTPase-activating protein function of ARHGAP21 , promoting activation of RhoA following angiotensin_II type 1A receptor stimulation .
14693677	0	angiotensin_II	30,44	SAM68	0,5	angiotensin II	SAM68	24179(Tax:10116)	117268(Tax:10116)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	SAM68 : a downstream target of angiotensin_II signaling in vascular smooth muscle cells in genetic hypertension .
12812653	0	angiotensin_II	64,78	STAT3	82,87	angiotensin II	STAT3	183	6774	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Changes of STAT3 in cell replicative senescence and effects of angiotensin_II on STAT3 -RSB- .
6751836	0	angiotensin_II	16,30	Sar1	45,49	angiotensin II	Sar1	183	56681	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Effect of three angiotensin_II antagonists , -LSB- Sar1 , Thr8 -RSB- - , -LSB- Sar1 , Ile8 -RSB- - and -LSB- Sar1 , Ala8 -RSB- angiotensin_II on blood pressure and endocrine factors in normal subjects .
22933020	0	angiotensin_II	77,91	Stanniocalcin-1	0,15	angiotensin II	Stanniocalcin-1	24179(Tax:10116)	81801(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Stanniocalcin-1 in the subfornical organ inhibits the dipsogenic response to angiotensin_II .
12960061	0	angiotensin_II	49,63	Suppressor_of_cytokine_signaling_3	0,34	angiotensin II	Suppressor of cytokine signaling 3	24179(Tax:10116)	89829(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Suppressor_of_cytokine_signaling_3 is induced by angiotensin_II in heart and isolated cardiomyocytes , and participates in desensitization .
17169354	0	angiotensin_II	70,84	TGF-beta1	8,17	angiotensin II	TGF-beta1	24179(Tax:10116)	59086(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of TGF-beta1 in vascular smooth muscle cell apoptosis induced by angiotensin_II .
10331853	0	angiotensin_II	56,70	TGF-beta_1	0,10	angiotensin II	TGF-beta 1	24179(Tax:10116)	59086(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY production|dep|role production|amod|END_ENTITY	TGF-beta_1 production in radiation nephropathy : role of angiotensin_II .
25867313	0	angiotensin_II	11,25	TIMP-1	56,62	angiotensin II	TIMP-1	24179(Tax:10116)	116510(Tax:10116)	Gene	Gene	intervention|amod|START_ENTITY Effects|nmod|intervention Effects|nmod|END_ENTITY	Effects of angiotensin_II intervention on MMP-2 , MMP-9 , TIMP-1 , and collagen expression in rats with pulmonary_hypertension .
24680379	0	angiotensin_II	21,35	TRPM7	0,5	angiotensin II	TRPM7	183	54822	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	TRPM7 is involved in angiotensin_II induced cardiac fibrosis development by mediating calcium and magnesium influx .
17495427	0	angiotensin_II	82,96	Toll-like_receptor_4	27,47	angiotensin II	Toll-like receptor 4	11606(Tax:10090)	21898(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Differential regulation of Toll-like_receptor_4 gene expression in renal cells by angiotensin_II : dependency on AP1 and PU .1 transcriptional sites .
25093580	0	angiotensin_II	37,51	Toll-like_receptor_4	0,20	angiotensin II	Toll-like receptor 4	24179(Tax:10116)	29260(Tax:10116)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Toll-like_receptor_4 upregulation by angiotensin_II contributes to hypertension and vascular_dysfunction through reactive oxygen species production .
19521712	0	angiotensin_II	86,100	VEGF	111,115	angiotensin II	VEGF	183	7422	Gene	Gene	increases|amod|START_ENTITY increases|acl:relcl|reduced reduced|nsubjpass|expression expression|compound|END_ENTITY	Regulated expression of the renin-angiotensin-system in human granulosa lutein cells : angiotensin_II increases VEGF expression but its synthesis is reduced by hCG .
15741767	0	angiotensin_II	69,83	adipocyte-derived_leucine_aminopeptidase	24,64	angiotensin II	adipocyte-derived leucine aminopeptidase	183	51752	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of adipocyte-derived_leucine_aminopeptidase via angiotensin_II in endometrial_carcinoma .
11410122	0	angiotensin_II	112,126	adrenomedullin	47,61	angiotensin II	adrenomedullin	183	133	Gene	Gene	infusion|nmod|START_ENTITY infusion|nsubj|thresholds thresholds|nmod|effects effects|nmod|END_ENTITY	Differing thresholds for modulatory effects of adrenomedullin infusion on haemodynamic and hormone responses to angiotensin_II and adrenocorticotrophic hormone in healthy volunteers .
11754973	0	angiotensin_II	63,77	adrenomedullin	11,25	angiotensin II	adrenomedullin	24179(Tax:10116)	25026(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of adrenomedullin on hypertrophic responses induced by angiotensin_II , endothelin-1 and phenylephrine .
14620929	0	angiotensin_II	60,74	adrenomedullin	78,92	angiotensin II	adrenomedullin	11606(Tax:10090)	11535(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Accelerated cardiac_hypertrophy and renal_damage induced by angiotensin_II in adrenomedullin knockout mice .
15295719	0	angiotensin_II	65,79	adrenomedullin	47,61	angiotensin II	adrenomedullin	24179(Tax:10116)	25026(Tax:10116)	Gene	Gene	contraction|amod|START_ENTITY study|nmod|contraction study|nmod|effects effects|nmod|END_ENTITY	Comparative study of the inhibitory effects of adrenomedullin on angiotensin_II contraction in rat conductance and resistance arteries .
27096064	0	angiotensin_II	76,90	adrenomedullin	14,28	angiotensin II	adrenomedullin	24179(Tax:10116)	25026(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|peptide peptide|compound|END_ENTITY	The effect of adrenomedullin and proadrenomedullin_N-terminal 20 peptide on angiotensin_II induced vascular smooth muscle cell proliferation .
10024339	0	angiotensin_II	62,76	aminopeptidase_A	7,23	angiotensin II	aminopeptidase A	24179(Tax:10116)	64017(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Kidney aminopeptidase_A and hypertension , part II : effects of angiotensin_II .
11729240	0	angiotensin_II	84,98	aminopeptidase_A	58,74	angiotensin II	aminopeptidase A	11606(Tax:10090)	13809(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Albuminuria|dep|role Albuminuria|nmod|mice mice|nmod|injection injection|nmod|antibodies antibodies|nmod|END_ENTITY	Albuminuria in mice after injection of antibodies against aminopeptidase_A : role of angiotensin_II .
12409962	0	angiotensin_II	143,157	aminopeptidase_A	24,40	angiotensin II	aminopeptidase A	24179(Tax:10116)	64017(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of aminopeptidase_A in hypertension in spontaneously hypertensive rats -LRB- SHRs -RRB- and change of refractoriness in response to angiotensin_II in pregnant SHRs .
6679727	0	angiotensin_II	76,90	aminopeptidase_A	32,48	angiotensin II	aminopeptidase A	183	2028	Gene	Gene	degradation|nmod|START_ENTITY properties|dep|degradation properties|nmod|END_ENTITY	Kinetic properties of placental aminopeptidase_A : N-terminal degradation of angiotensin_II .
16769060	0	angiotensin_II	16,30	angiotensin-converting_enzyme	50,79	angiotensin II	angiotensin-converting enzyme	183	1636	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of angiotensin_II , the AT1 receptor , angiotensin-converting_enzyme , aminopeptidase_A , adipocyte-derived_leucine_aminopeptidase , and vascular_endothelial_growth_factor in the human ovary throughout the menstrual cycle .
8385419	0	angiotensin_II	89,103	angiotensin-converting_enzyme	38,67	angiotensin II	angiotensin-converting enzyme	183	1636	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Structure and regulated expression of angiotensin-converting_enzyme and the receptor for angiotensin_II .
8973755	0	angiotensin_II	63,77	angiotensin-converting_enzyme	30,59	angiotensin II	angiotensin-converting enzyme	24179(Tax:10116)	24310(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Tissue-specific regulation of angiotensin-converting_enzyme by angiotensin_II and losartan in the rat .
190881	0	angiotensin_II	31,45	angiotensin_I	14,27	angiotensin II	angiotensin I	183	183	Gene	Gene	Conversion|nmod|START_ENTITY Conversion|nmod|END_ENTITY	Conversion of angiotensin_I to angiotensin_II .
1071654	0	angiotensin_II	112,126	angiotensin_II	63,77	angiotensin II	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Blood pressure response to central and peripheral injection of angiotensin_II and 8-C-phenylglycine analogue of angiotensin_II in rats with experimental hypertension .
1071654	0	angiotensin_II	63,77	angiotensin_II	112,126	angiotensin II	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Blood pressure response to central and peripheral injection of angiotensin_II and 8-C-phenylglycine analogue of angiotensin_II in rats with experimental hypertension .
2616380	0	angiotensin_II	11,25	angiotensin_II	45,59	angiotensin II	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of angiotensin_II and its fragments : angiotensin_II -LRB- 3-8 -RRB- - hexapeptide and angiotensin_II -LRB- 4-8 -RRB- - pentapeptide on retrieval in passive avoidance situation in rats chronically treated with ethanol .
2616380	0	angiotensin_II	45,59	angiotensin_II	11,25	angiotensin II	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of angiotensin_II and its fragments : angiotensin_II -LRB- 3-8 -RRB- - hexapeptide and angiotensin_II -LRB- 4-8 -RRB- - pentapeptide on retrieval in passive avoidance situation in rats chronically treated with ethanol .
3414846	0	angiotensin_II	58,72	angiotensin_II	7,21	angiotensin II	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Plasma angiotensin_II levels at moment of drinking during angiotensin_II intravenous infusion .
3414846	0	angiotensin_II	7,21	angiotensin_II	58,72	angiotensin II	angiotensin II	24179(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nmod|infusion infusion|amod|END_ENTITY	Plasma angiotensin_II levels at moment of drinking during angiotensin_II intravenous infusion .
2596583	0	angiotensin_II	44,58	angiotensinogen	14,29	angiotensin II	angiotensinogen	183	183	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Inhibition of angiotensinogen production by angiotensin_II analogues in human hepatoma cell line .
3241235	0	angiotensin_II	44,58	angiotensinogen	14,29	angiotensin II	angiotensinogen	183	183	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Regulation of angiotensinogen production by angiotensin_II analogues .
7685351	0	angiotensin_II	20,34	annexin_I	66,75	angiotensin II	annexin I	24179(Tax:10116)	25380(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Sustained effect of angiotensin_II on tyrosine phosphorylation of annexin_I in glomerular mesangial cells .
21763672	0	angiotensin_II	22,36	apoE	40,44	angiotensin II	apoE	11606(Tax:10090)	11816(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Prolonged infusion of angiotensin_II in apoE -LRB- - / - -RRB- mice promotes macrophage recruitment with continued expansion of abdominal_aortic_aneurysm .
20663307	0	angiotensin_II	11,25	aquaporin_1	47,58	angiotensin II	aquaporin 1	24179(Tax:10116)	25240(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of angiotensin_II on the expression of aquaporin_1 in lung of rats following acute_lung_injury -RSB- .
2530271	0	angiotensin_II	64,78	atrial_natriuretic_factor	35,60	angiotensin II	atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	elevation|amod|START_ENTITY END_ENTITY|nmod|elevation	Effects of intracerebroventricular atrial_natriuretic_factor on angiotensin_II - or sodium-induced blood pressure elevation and natriuresis .
2843514	0	angiotensin_II	53,67	atrial_natriuretic_factor	14,39	angiotensin II	atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Regulation of atrial_natriuretic_factor receptors by angiotensin_II in rat vascular smooth muscle cells .
2942948	0	angiotensin_II	70,84	atrial_natriuretic_factor	11,36	angiotensin II	atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_factor on drinking responses to central angiotensin_II .
3023030	0	angiotensin_II	53,67	atrial_natriuretic_factor	24,49	angiotensin II	atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	Differential effects of atrial_natriuretic_factor on angiotensin_II - and adrenocorticotropin-stimulated aldosterone secretion .
6242556	0	angiotensin_II	62,76	atrial_natriuretic_factor	24,49	angiotensin II	atrial natriuretic factor	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubj|response response|nmod|END_ENTITY	Natriuretic response to atrial_natriuretic_factor enhanced by angiotensin_II and vasopressin .
8386485	0	angiotensin_II	11,25	atrial_natriuretic_peptide	50,76	angiotensin II	atrial natriuretic peptide	24179(Tax:10116)	24602(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|effect effect|nmod|END_ENTITY	Endogenous angiotensin_II modulates the effect of atrial_natriuretic_peptide on extracellular fluid partition .
10440105	0	angiotensin_II	96,110	c-Fos	54,59	angiotensin II	c-Fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	indispensable|nmod|START_ENTITY indispensable|nmod|expression expression|amod|END_ENTITY	Epidermal_growth_factor_receptor is indispensable for c-Fos expression and protein synthesis by angiotensin_II .
11562426	0	angiotensin_II	105,119	c-Jun_N-terminal_kinase	67,90	angiotensin II	c-Jun N-terminal kinase	24179(Tax:10116)	116554(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|amod|END_ENTITY	Quercetin inhibits Shc - and phosphatidylinositol 3-kinase-mediated c-Jun_N-terminal_kinase activation by angiotensin_II in cultured rat aortic smooth muscle cells .
12663375	0	angiotensin_II	93,107	c-Src	0,5	angiotensin II	c-Src	183	6714	Gene	Gene	induces|nmod|START_ENTITY induces|dep|END_ENTITY	c-Src induces phosphorylation and translocation of p47phox : role in superoxide generation by angiotensin_II in human vascular smooth muscle cells .
11498949	0	angiotensin_II	11,25	c-fos	29,34	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of angiotensin_II on c-fos expression and protein synthesis in cultured rat myocardial cells -RSB- .
17762649	0	angiotensin_II	194,208	c-fos	133,138	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY signaling|dobj|effect END_ENTITY|xcomp|signaling	Upregulation of AT1 receptor gene on activation of protein_kinase_Cbeta / nicotinamide_adenine_dinucleotide_diphosphate oxidase/ERK1/2 / c-fos signaling cascade mediates long-term pressor effect of angiotensin_II in rostral ventrolateral medulla .
17763940	0	angiotensin_II	56,70	c-fos	14,19	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of c-fos , c-jun and c-myc gene expression by angiotensin_II in primary cultured rat astrocytes : role of ERK1/2 MAP kinases .
18619357	0	angiotensin_II	82,96	c-fos	12,17	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Changes Changes|nmod|expressions expressions|amod|END_ENTITY	-LSB- Changes of c-fos , c-jun mRNA expressions in cardiomyocyte hypertrophy induced by angiotensin_II and effects of tanshinone_II A -RSB- .
7477894	0	angiotensin_II	102,116	c-fos	67,72	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|suppression suppression|nmod|lesions lesions|nmod|ventricle ventricle|nmod|expression expression|amod|END_ENTITY	Regional suppression by lesions in the anterior third ventricle of c-fos expression induced by either angiotensin_II or hypertonic saline .
7820657	0	angiotensin_II	98,112	c-fos	40,45	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	infusions|nmod|START_ENTITY induced|nmod|infusions induced|nsubj|suppression suppression|nmod|intake intake|nmod|expression expression|amod|END_ENTITY	Regional suppression by water intake of c-fos expression induced by intraventricular infusions of angiotensin_II .
8348687	0	angiotensin_II	32,46	c-fos	56,61	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	pathways|nmod|START_ENTITY pathways|dep|expression expression|amod|END_ENTITY	Signal transduction pathways of angiotensin_II -- induced c-fos gene expression in cardiac myocytes in vitro .
8637618	0	angiotensin_II	160,174	c-fos	72,77	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY forebrain|nmod|injection release|nmod|forebrain release|nmod|expression expression|amod|END_ENTITY	The association of thirst , sodium_appetite and vasopressin release with c-fos expression in the forebrain of the rat after intracerebroventricular injection of angiotensin_II , angiotensin - -LRB- 1-7 -RRB- or carbachol .
8896808	0	angiotensin_II	90,104	c-fos	119,124	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	antagonism|nmod|START_ENTITY antagonism|dep|mapping mapping|nmod|END_ENTITY	Central antagonism of atrial natriuretic peptides on behavioral and hormonal responses to angiotensin_II : mapping with c-fos .
9839532	0	angiotensin_II	34,48	c-fos	6,11	angiotensin II	c-fos	24179(Tax:10116)	314322(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Renal c-fos expression induced by angiotensin_II is enhanced in spontaneously hypertensive rats .
17942630	0	angiotensin_II	103,117	caveolin-1	10,20	angiotensin II	caveolin-1	183	857	Gene	Gene	evoked|nmod|START_ENTITY evoked|nsubj|Effect Effect|nmod|peptide peptide|amod|END_ENTITY	Effect of caveolin-1 scaffolding peptide and 17beta-estradiol on intracellular Ca2 + kinetics evoked by angiotensin_II in human vascular smooth muscle cells .
21659644	0	angiotensin_II	116,130	caveolin-1	9,19	angiotensin II	caveolin-1	183	857	Gene	Gene	uncoupling|nmod|START_ENTITY endothelial_nitric_oxide_synthase|dep|uncoupling prevents|dobj|endothelial_nitric_oxide_synthase prevents|nsubj|downregulation downregulation|amod|END_ENTITY	Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial_nitric_oxide_synthase uncoupling by angiotensin_II in endothelial cells .
24049538	0	angiotensin_II	13,27	caveolin-1	55,65	angiotensin II	caveolin-1	183	857	Gene	Gene	blocker|compound|START_ENTITY blocker|nmod|expression expression|amod|END_ENTITY	Effect of an angiotensin_II type 1 receptor blocker on caveolin-1 expression in prostate_cancer cells .
25164083	0	angiotensin_II	55,69	caveolin_1	8,18	angiotensin II	caveolin 1	183	857	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of caveolin_1 in AT1a receptor-mediated uptake of angiotensin_II in the proximal tubule of the kidney .
11502696	0	angiotensin_II	72,86	chymase	43,50	angiotensin II	chymase	183	1215	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Functional evidence for a role of vascular chymase in the production of angiotensin_II in isolated human arteries .
12151872	0	angiotensin_II	34,48	chymase	23,30	angiotensin II	chymase	183	1215	Gene	Gene	formation|amod|START_ENTITY Dissecting|nmod|formation Dissecting|dobj|role role|nmod|END_ENTITY	Dissecting the role of chymase in angiotensin_II formation and heart_and_blood_vessel_diseases .
15590479	0	angiotensin_II	43,57	chymase	196,203	angiotensin II	chymase	183	1215	Gene	Gene	systems|amod|START_ENTITY activities|nmod|systems Measurement|nmod|activities Measurement|dep|involvement involvement|nmod|END_ENTITY	Measurement of activities in two different angiotensin_II generating systems , chymase and angiotensin-converting_enzyme , in the vitreous fluid of vitreoretinal_diseases : a possible involvement of chymase in the pathogenesis of macular hole patients .
15590479	0	angiotensin_II	43,57	chymase	78,85	angiotensin II	chymase	183	1215	Gene	Gene	systems|amod|START_ENTITY activities|nmod|systems Measurement|nmod|activities Measurement|amod|END_ENTITY	Measurement of activities in two different angiotensin_II generating systems , chymase and angiotensin-converting_enzyme , in the vitreous fluid of vitreoretinal_diseases : a possible involvement of chymase in the pathogenesis of macular hole patients .
25787365	0	angiotensin_II	125,139	chymase	49,56	angiotensin II	chymase	183	1215	Gene	Gene	generation|amod|START_ENTITY mechanism|nmod|generation activation|dep|mechanism activation|amod|END_ENTITY	-LSB- 17-OR -RSB- : Histone deacetylase inhibition promotes chymase activation in endothelial cells : A potential mechanism of increased angiotensin_II generation in preeclampsia .
8293772	0	angiotensin_II	8,22	chymase	80,87	angiotensin II	chymase	183	1215	Gene	Gene	formation|compound|START_ENTITY formation|dep|END_ENTITY	Cardiac angiotensin_II formation : the angiotensin-I_converting_enzyme and human chymase .
9257695	0	angiotensin_II	32,46	chymase	13,20	angiotensin II	chymase	183	1215	Gene	Gene	forms|dobj|START_ENTITY END_ENTITY|acl:relcl|forms	Induction of chymase that forms angiotensin_II in the monkey atherosclerotic aorta .
9285934	0	angiotensin_II	31,45	chymase	49,56	angiotensin II	chymase	183	1215	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Conversion of angiotensin_I to angiotensin_II by chymase activity in human pulmonary membranes .
9821858	0	angiotensin_II	30,44	chymase	19,26	angiotensin II	chymase	183	1215	Gene	Gene	formation|amod|START_ENTITY role|nmod|formation role|nmod|END_ENTITY	Functional role of chymase in angiotensin_II formation in human vascular tissue .
14583661	0	angiotensin_II	108,122	connective_tissue_growth_factor	8,39	angiotensin II	connective tissue growth factor	183	1490	Gene	Gene	induced|nmod|START_ENTITY Role|acl|induced Role|nmod|END_ENTITY	Role of connective_tissue_growth_factor in mediating hypertrophy of human proximal tubular cells induced by angiotensin_II .
18319604	0	angiotensin_II	66,80	connective_tissue_growth_factor	31,62	angiotensin II	connective tissue growth factor	183	14219(Tax:10090)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	SGK1-dependent upregulation of connective_tissue_growth_factor by angiotensin_II .
11463347	0	angiotensin_II	10,24	connexin_43	58,69	angiotensin II	connexin 43	24179(Tax:10116)	24392(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of angiotensin_II and ethanol on the expression of connexin_43 in WB rat liver epithelial cells .
6320315	0	angiotensin_II	10,24	corticotropin-releasing_factor	58,88	angiotensin II	corticotropin-releasing factor	24179(Tax:10116)	81648(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of angiotensin_II on ACTH release in vivo : role of corticotropin-releasing_factor .
18827978	0	angiotensin_II	69,83	cyclooxygenase-2	29,45	angiotensin II	cyclooxygenase-2	183	5743	Gene	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|nsubj|induction induction|nmod|END_ENTITY	The synergistic induction of cyclooxygenase-2 in lung fibroblasts by angiotensin_II and pro-inflammatory cytokines .
20668099	0	angiotensin_II	78,92	cyclooxygenase-2	10,26	angiotensin II	cyclooxygenase-2	24179(Tax:10116)	29527(Tax:10116)	Gene	Gene	states|nmod|START_ENTITY Augmented|nmod|states Augmented|dobj|effects effects|amod|END_ENTITY	Augmented cyclooxygenase-2 effects on renal function during varying states of angiotensin_II .
10027431	0	angiotensin_II	18,32	endothelin-1	79,91	angiotensin II	endothelin-1	183	1906	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of infused angiotensin_II on the bronchoconstrictor activity of inhaled endothelin-1 in asthma .
10501344	0	angiotensin_II	15,29	endothelin-1	53,65	angiotensin II	endothelin-1	183	1906	Gene	Gene	antagonist|amod|START_ENTITY Effects|nmod|antagonist losartan|nsubj|Effects losartan|nmod|levels levels|amod|END_ENTITY	Effects of the angiotensin_II antagonist losartan on endothelin-1 and norepinephrine plasma levels during cold pressor test in patients with chronic_heart_failure .
11479261	0	angiotensin_II	24,38	endothelin-1	46,58	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibitions inhibitions|amod|END_ENTITY	Differential effects of angiotensin_II versus endothelin-1 inhibitions in hypertrophic_left_ventricular_myocardium during transition to heart_failure .
12410847	0	angiotensin_II	77,91	endothelin-1	8,20	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of endothelin-1 and thromboxane_A2 in renal vasoconstriction induced by angiotensin_II in diabetes and hypertension .
1310444	0	angiotensin_II	85,99	endothelin-1	50,62	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|dobj|response response|amod|END_ENTITY	Atrial and brain_natriuretic_peptides inhibit the endothelin-1 secretory response to angiotensin_II in porcine aorta .
15613065	0	angiotensin_II	137,151	endothelin-1	51,63	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY modifies|nmod|response modifies|dobj|mediation mediation|nmod|END_ENTITY	AT-1 receptor antagonism modifies the mediation of endothelin-1 , thromboxane_A2 , and catecholamines in the renal constrictor response to angiotensin_II .
15831659	0	angiotensin_II	14,28	endothelin-1	37,49	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY induced|nsubj|Inhibition induced|dobj|expression expression|amod|END_ENTITY	Inhibition of angiotensin_II induced endothelin-1 gene expression by 17-beta-oestradiol in rat cardiac fibroblasts .
1645748	0	angiotensin_II	101,115	endothelin-1	55,67	angiotensin II	endothelin-1	183	1906	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|atrial atrial|nmod|secretion secretion|amod|END_ENTITY	Inhibition by atrial and brain_natriuretic_peptides of endothelin-1 secretion after stimulation with angiotensin_II and thrombin of cultured human endothelial cells .
16505203	0	angiotensin_II	33,47	endothelin-1	57,69	angiotensin II	endothelin-1	183	1906	Gene	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|species species|amod|END_ENTITY	The positive inotropic effect of angiotensin_II : role of endothelin-1 and reactive oxygen species .
7688575	0	angiotensin_II	35,49	endothelin-1	14,26	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation of endothelin-1 mRNA by angiotensin_II in rat heart endothelial cells .
8782666	0	angiotensin_II	147,161	endothelin-1	86,98	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	response|amod|START_ENTITY size|nmod|response using|nmod|size using|dobj|influence influence|amod|END_ENTITY	A comparative study of tumour blood flow modification in two rat tumour systems using endothelin-1 and angiotensin_II : influence of tumour size on angiotensin_II response .
9146895	0	angiotensin_II	18,32	endothelin-1	73,85	angiotensin II	endothelin-1	24179(Tax:10116)	24323(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|cells cells|amod|END_ENTITY	Trophic effect of angiotensin_II in neonatal rat cardiomyocytes : role of endothelin-1 and non-myocyte cells .
21712088	0	angiotensin_II	85,99	epidermal_growth_factor_receptor	19,51	angiotensin II	epidermal growth factor receptor	24179(Tax:10116)	24329(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Transactivation of epidermal_growth_factor_receptor by enhanced levels of endogenous angiotensin_II contributes to the overexpression of Gia proteins in vascular smooth muscle cells from SHR .
21944177	0	angiotensin_II	11,25	epithelial_sodium_channel	52,77	angiotensin II	epithelial sodium channel	24179(Tax:10116)	24768(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	-LSB- Effect of angiotensin_II on expression of alveolar epithelial_sodium_channel in rat -RSB- .
10784360	0	angiotensin_II	25,39	erythropoietin	49,63	angiotensin II	erythropoietin	183	2056	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	Dose-dependent effect of angiotensin_II on human erythropoietin production .
12968982	0	angiotensin_II	29,43	erythropoietin	60,74	angiotensin II	erythropoietin	183	2056	Gene	Gene	levels|compound|START_ENTITY alterations|nmod|levels regulate|nsubj|alterations regulate|dobj|production production|compound|END_ENTITY	Do alterations of endogenous angiotensin_II levels regulate erythropoietin production in humans ?
15627795	0	angiotensin_II	5,19	erythropoietin	29,43	angiotensin II	erythropoietin	183	2056	Gene	Gene	modulate|nsubj|START_ENTITY modulate|dobj|production production|compound|END_ENTITY	Does angiotensin_II modulate erythropoietin production in HepG2 cells ?
24695083	0	angiotensin_II	42,56	erythropoietin	13,27	angiotensin II	erythropoietin	183	2056	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|regulation regulation|compound|END_ENTITY	Mechanism of erythropoietin regulation by angiotensin_II .
12949261	0	angiotensin_II	64,78	extracellular_signal-regulated_kinases_1_and_2	93,139	angiotensin II	extracellular signal-regulated kinases 1 and 2	183	5594	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Independent beta-arrestin_2 and G protein-mediated pathways for angiotensin_II activation of extracellular_signal-regulated_kinases_1_and_2 .
2126223	0	angiotensin_II	82,96	growth_hormone	100,114	angiotensin II	growth hormone	24179(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Evidence for a pertussis toxin-sensitive signalling pathway in the dual action of angiotensin_II on growth_hormone release in pituitary cell aggregates .
2170820	0	angiotensin_II	59,73	growth_hormone	15,29	angiotensin II	growth hormone	183	2688	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of growth_hormone and corticotropin release by angiotensin_II in man .
11302771	0	angiotensin_II	64,78	heme_oxygenase_1	13,29	angiotensin II	heme oxygenase 1	24179(Tax:10116)	24451(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of heme_oxygenase_1 in radiation nephropathy : role of angiotensin_II .
10454454	0	angiotensin_II	30,44	hepatocyte_growth_factor	86,110	angiotensin II	hepatocyte growth factor	24179(Tax:10116)	24446(Tax:10116)	Gene	Gene	renal_damage|nmod|START_ENTITY blockade|amod|renal_damage blockade|acl|accompanied accompanied|nmod|END_ENTITY	Prevention of renal_damage by angiotensin_II blockade , accompanied by increased renal hepatocyte_growth_factor in experimental hypertensive rats .
10889138	0	angiotensin_II	121,135	hepatocyte_growth_factor	55,79	angiotensin II	hepatocyte growth factor	183	3082	Gene	Gene	blockade|amod|START_ENTITY myocardial_fibrosis|nmod|blockade contribution|nmod|myocardial_fibrosis contribution|nmod|factor factor|appos|END_ENTITY	Potential contribution of a novel antifibrotic factor , hepatocyte_growth_factor , to prevention of myocardial_fibrosis by angiotensin_II blockade in cardiomyopathic_hamsters .
12644877	0	angiotensin_II	42,56	hepatocyte_growth_factor	103,127	angiotensin II	hepatocyte growth factor	24179(Tax:10116)	24446(Tax:10116)	Gene	Gene	blockade|amod|START_ENTITY endothelial_dysfunction|nmod|blockade Improvement|nmod|endothelial_dysfunction accompanied|nsubj|Improvement accompanied|nmod|induction induction|nmod|system system|compound|END_ENTITY	Improvement of endothelial_dysfunction by angiotensin_II blockade accompanied by induction of vascular hepatocyte_growth_factor system in diabetic spontaneously hypertensive rats .
19713535	0	angiotensin_II	60,74	hepatocyte_growth_factor	19,43	angiotensin II	hepatocyte growth factor	11606(Tax:10090)	15234(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY system|nmod|signaling action|dep|system action|nmod|END_ENTITY	Negative action of hepatocyte_growth_factor / c-Met system on angiotensin_II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells .
9403566	0	angiotensin_II	8,22	hepatocyte_growth_factor	72,96	angiotensin II	hepatocyte growth factor	24179(Tax:10116)	24446(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|modulator modulator|appos|END_ENTITY	Role of angiotensin_II in the regulation of a novel vascular modulator , hepatocyte_growth_factor -LRB- HGF -RRB- , in experimental hypertensive rats .
9740609	0	angiotensin_II	68,82	hepatocyte_growth_factor	29,53	angiotensin II	hepatocyte growth factor	24179(Tax:10116)	24446(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Negative regulation of local hepatocyte_growth_factor expression by angiotensin_II and transforming growth factor-beta in blood vessels : potential role of HGF in cardiovascular_disease .
12691602	0	angiotensin_II	94,108	insulin	112,119	angiotensin II	insulin	183	3630	Gene	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Decreased_insulin_sensitivity during dietary sodium restriction is not mediated by effects of angiotensin_II on insulin action .
8222508	0	angiotensin_II	11,25	insulin	29,36	angiotensin II	insulin	183	3630	Gene	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of angiotensin_II on insulin sensitivity : a placebo-controlled study .
9243097	0	angiotensin_II	11,25	insulin_receptor	29,45	angiotensin II	insulin receptor	24179(Tax:10116)	3643	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of angiotensin_II on insulin_receptor binding and mRNA levels in normal and diabetic rats .
10406834	0	angiotensin_II	41,55	interleukin-6	13,26	angiotensin II	interleukin-6	24179(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin-6 expression by angiotensin_II in rat vascular smooth muscle cells .
12536569	0	angiotensin_II	12,26	interleukin-6	62,75	angiotensin II	interleukin-6	183	3569	Gene	Gene	START_ENTITY|nmod|proliferation proliferation|nmod|END_ENTITY	-LSB- Effects of angiotensin_II on proliferation and expression of interleukin-6 of human kidney fibroblasts -RSB- .
17059008	0	angiotensin_II	25,39	interleukin-6	48,61	angiotensin II	interleukin-6	24179(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|xcomp|END_ENTITY	-LSB- Effects of quercetin on angiotensin_II induced interleukin-6 in vascular smooth muscle cells -RSB- .
16822558	0	angiotensin_II	57,71	kinin_B1_receptor	14,31	angiotensin II	kinin B1 receptor	24179(Tax:10116)	81509(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of kinin_B1_receptor expression by endogenous angiotensin_II in hypertensive rats .
16806260	0	angiotensin_II	84,98	leptin	22,28	angiotensin II	leptin	24179(Tax:10116)	25608(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY mediating|dobj|effects END_ENTITY|acl|mediating	An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin_II and endothelin-1 .
21806545	0	angiotensin_II	83,97	leptin	54,60	angiotensin II	leptin	183	3952	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Mechanism Mechanism|nmod|effect effect|nmod|atorvastatin atorvastatin|nmod|expression expression|compound|END_ENTITY	Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin_II in cultured human coronary artery smooth muscle cells .
11606427	0	angiotensin_II	56,70	macrophage_migration_inhibitory_factor	14,52	angiotensin II	macrophage migration inhibitory factor	24179(Tax:10116)	103694877	Gene	Gene	regulation|amod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Novel role of macrophage_migration_inhibitory_factor in angiotensin_II regulation of neuromodulation in rat brain .
24740791	0	angiotensin_II	47,61	megalin	139,146	angiotensin II	megalin	24179(Tax:10116)	29216(Tax:10116)	Gene	Gene	uptake|nmod|START_ENTITY Mechanisms|nmod|uptake Mechanisms|dep|role role|nmod|END_ENTITY	Mechanisms of AT1a receptor-mediated uptake of angiotensin_II by proximal tubule cells : a novel role of the multiligand endocytic receptor megalin .
15634454	0	angiotensin_II	88,102	monocyte_chemoattractant_protein-1	14,48	angiotensin II	monocyte chemoattractant protein-1	183	6347	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	-LSB- Induction of monocyte_chemoattractant_protein-1 expression in human mesangial cells by angiotensin_II : role of c-Jun N-terminal kinase-c-Jun/activator protein-1 signal pathway -RSB- .
17303665	0	angiotensin_II	62,76	monocyte_chemoattractant_protein-1	13,47	angiotensin II	monocyte chemoattractant protein-1	11606(Tax:10090)	20296(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of monocyte_chemoattractant_protein-1 expression by angiotensin_II in the pancreatic islets and beta-cells .
17697525	0	angiotensin_II	16,30	monocyte_chemoattractant_protein-1	110,144	angiotensin II	monocyte chemoattractant protein-1	183	6347	Gene	Gene	blocker|compound|START_ENTITY Telmisartan|appos|blocker inhibits|nsubj|Telmisartan inhibits|dobj|end-product end-product|acl:relcl|induced induced|dobj|expression expression|amod|END_ENTITY	Telmisartan , an angiotensin_II type 1 receptor blocker , inhibits advanced glycation end-product -LRB- AGE -RRB- - induced monocyte_chemoattractant_protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome_proliferator-activated_receptor-gamma activation .
18511912	0	angiotensin_II	54,68	myosin_light_chain_kinase	14,39	angiotensin II	myosin light chain kinase	24179(Tax:10116)	288057(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of myosin_light_chain_kinase expression by angiotensin_II in hypertension .
19578649	0	angiotensin_II	11,25	nNOS	36,40	angiotensin II	nNOS	24179(Tax:10116)	24598(Tax:10116)	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Endogenous angiotensin_II modulates nNOS expression in renovascular_hypertension .
11055977	0	angiotensin_II	87,101	nuclear_factor-kappaB	54,75	angiotensin II	nuclear factor-kappaB	183	4790	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Hyperinsulinemia enhances transcriptional activity of nuclear_factor-kappaB induced by angiotensin_II , hyperglycemia , and advanced glycosylation end products in vascular smooth muscle cells .
15213258	0	angiotensin_II	22,36	p27	99,102	angiotensin II	p27	24179(Tax:10116)	83571(Tax:10116)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|preventing preventing|dobj|upregulation upregulation|nmod|END_ENTITY	Simvastatin modulates angiotensin_II signaling pathway by preventing Rac1-mediated upregulation of p27 .
12663375	0	angiotensin_II	93,107	p47phox	51,58	angiotensin II	p47phox	183	653361	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	c-Src induces phosphorylation and translocation of p47phox : role in superoxide generation by angiotensin_II in human vascular smooth muscle cells .
15618548	0	angiotensin_II	136,150	p47phox	0,7	angiotensin II	p47phox	183	653361	Gene	Gene	oxidase|nmod|START_ENTITY oxidase|nsubj|associates associates|amod|END_ENTITY	p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells : role in NAD -LRB- P -RRB- H oxidase regulation by angiotensin_II .
15775784	0	angiotensin_II	137,151	p47phox	42,49	angiotensin II	p47phox	183	653361	Gene	Gene	role|nmod|START_ENTITY over-activation|parataxis|role over-activation|nmod|END_ENTITY	Angiotensin_II-induced over-activation of p47phox in fibroblasts from hypertensives : which role in the enhanced ERK1/2 responsiveness to angiotensin_II ?
17374653	0	angiotensin_II	124,138	p47phox	105,112	angiotensin II	p47phox	24179(Tax:10116)	114553(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Quercetin and isorhamnetin prevent endothelial_dysfunction , superoxide production , and overexpression of p47phox induced by angiotensin_II in rat aorta .
23850797	0	angiotensin_II	10,24	per2	37,41	angiotensin II	per2	24179(Tax:10116)	63840(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of angiotensin_II on rhythmic per2 expression in the suprachiasmatic nucleus and heart and daily rhythm of activity in Wistar_rats .
19118280	0	angiotensin_II	76,90	peroxisome_proliferator-activated_receptor-gamma	15,63	angiotensin II	peroxisome proliferator-activated receptor-gamma	183	5468	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Suppression of peroxisome_proliferator-activated_receptor-gamma activity by angiotensin_II in vascular smooth muscle involves Bcr kinase : the fire that drowns the water .
1513321	0	angiotensin_II	27,41	phospholipase_C-alpha	57,78	angiotensin II	phospholipase C-alpha	11606(Tax:10090)	14827(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY Association|nmod|receptors Association|nmod|END_ENTITY	Association of solubilized angiotensin_II receptors with phospholipase_C-alpha in murine neuroblastoma NIE-115 cells .
7541047	0	angiotensin_II	53,67	phospholipase_C-gamma_1	82,105	angiotensin II	phospholipase C-gamma 1	24179(Tax:10116)	25738(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|cells cells|amod|END_ENTITY	Electroporation of pp60c-src antibodies inhibits the angiotensin_II activation of phospholipase_C-gamma_1 in rat aortic smooth muscle cells .
4339394	0	angiotensin_II	15,29	plasmin	33,40	angiotensin II	plasmin	183	5340	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of angiotensin_II by plasmin .
14581407	0	angiotensin_II	86,100	plasminogen_activator_inhibitor-1	20,53	angiotensin II	plasminogen activator inhibitor-1	11606(Tax:10090)	18787(Tax:10090)	Gene	Gene	mediator|nmod|START_ENTITY mediator|dep|END_ENTITY	Aldosterone and not plasminogen_activator_inhibitor-1 is a critical mediator of early angiotensin_II / NG-nitro-L-arginine_methyl_ester-induced myocardial_injury .
19051364	0	angiotensin_II	97,111	plasminogen_activator_inhibitor-1	30,63	angiotensin II	plasminogen activator inhibitor-1	24179(Tax:10116)	24617(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY depresses|nmod|inhibition depresses|dobj|production production|amod|END_ENTITY	Salvia miltiorrhiza depresses plasminogen_activator_inhibitor-1 production through inhibition of angiotensin_II .
9531054	0	angiotensin_II	117,131	plasminogen_activator_inhibitor_1	72,105	angiotensin II	plasminogen activator inhibitor 1	24179(Tax:10116)	24617(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Atrial_natriuretic_peptide inhibits the expression of tissue factor and plasminogen_activator_inhibitor_1 induced by angiotensin_II in cultured rat aortic endothelial cells .
2649516	0	angiotensin_II	82,96	platelet-derived_growth_factor_A-chain	13,51	angiotensin II	platelet-derived growth factor A-chain	24179(Tax:10116)	25266(Tax:10116)	Gene	Gene	expressions|nmod|START_ENTITY expressions|amod|END_ENTITY	Induction of platelet-derived_growth_factor_A-chain and c-myc gene expressions by angiotensin_II in cultured rat vascular smooth muscle cells .
16189269	0	angiotensin_II	63,77	platelet-derived_growth_factor_D-chain	10,48	angiotensin II	platelet-derived growth factor D-chain	183	80310	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inducible platelet-derived_growth_factor_D-chain expression by angiotensin_II and hydrogen_peroxide involves transcriptional regulation by Ets-1 and Sp1 .
11888852	0	angiotensin_II	12,26	prolactin	42,51	angiotensin II	prolactin	24179(Tax:10116)	24683(Tax:10116)	Gene	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Evidence of angiotensin_II involvement in prolactin secretion in response to hemorrhage in adrenodemedullated and guanethidine-treated rats .
2119001	0	angiotensin_II	41,55	proto-oncogene_c-jun	17,37	angiotensin II	proto-oncogene c-jun	24179(Tax:10116)	24516(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of the proto-oncogene_c-jun by angiotensin_II .
18398336	0	angiotensin_II	63,77	regulator_of_G_protein_signaling-2	10,44	angiotensin II	regulator of G protein signaling-2	183	5997	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Silencing regulator_of_G_protein_signaling-2 -LRB- RGS-2 -RRB- increases angiotensin_II signaling : insights into hypertension from findings in Bartter 's / Gitelman 's _ syndromes .
10450835	0	angiotensin_II	141,155	renin	122,127	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Angiotensin_II_type_1_receptor expression in two cases of juxtaglomerular_cell_tumor : correlation to negative feedback of renin secretion by angiotensin_II .
10536699	0	angiotensin_II	169,183	renin	73,78	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	cardiomyocyte|nmod|START_ENTITY evidence|nmod|cardiomyocyte rat|dep|evidence rat|acl:relcl|synthesize synthesize|dobj|END_ENTITY	Cultured neonatal rat cardiac myocytes and fibroblasts do not synthesize renin or angiotensinogen : evidence for stretch-induced cardiomyocyte hypertrophy independent of angiotensin_II .
10555568	0	angiotensin_II	73,87	renin	54,59	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	attenuate|nmod|START_ENTITY attenuate|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Chloride channel blockers attenuate the inhibition of renin secretion by angiotensin_II .
1071608	0	angiotensin_II	22,36	renin	48,53	angiotensin II	renin	183	5972	Gene	Gene	Dissociation|nmod|START_ENTITY END_ENTITY|nsubj|Dissociation	Dissociation of blood angiotensin_II and plasma renin activity during chronic treatment in essential hypertension .
1077776	0	angiotensin_II	75,89	renin	20,25	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	antibodies|amod|START_ENTITY injection|nmod|antibodies rats|nmod|injection systems|nmod|rats response|dep|systems response|nmod|END_ENTITY	The response of the renin -- angiotensin systems in rats to the injection of angiotensin_II antibodies .
1126059	0	angiotensin_II	7,21	renin	23,28	angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|appos|concentrations concentrations|compound|END_ENTITY	Plasma angiotensin_II , renin , renin-substrate and aldosterone concentrations in acute_renal_failure in man .
11403100	0	angiotensin_II	7,21	renin	23,28	angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|appos|activity activity|compound|END_ENTITY	Plasma angiotensin_II , renin activity and serum angiotensin-converting_enzyme activity in non-insulin_dependent_diabetes_mellitus patients with diabetic_nephropathy .
11702851	0	angiotensin_II	68,82	renin	116,121	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Nitric_oxide synthase mRNA levels correlate with gene expression of angiotensin_II type-1 but not type-2 receptors , renin or angiotensin converting enzyme in selected brain areas .
12045255	0	angiotensin_II	47,61	renin	99,104	angiotensin II	renin	183	5972	Gene	Gene	production|amod|START_ENTITY _|nmod|production _|nmod|END_ENTITY	Pivotal role of the renin/prorenin _ receptor in angiotensin_II production and cellular responses to renin .
1262200	0	angiotensin_II	33,47	renin	5,10	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY accompanying|dobj|inhibition activity|acl|accompanying activity|compound|END_ENTITY	High renin activity accompanying angiotensin_II inhibition in rats with ischemic_renal_failure .
1312512	0	angiotensin_II	10,24	renin	28,33	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Effect of angiotensin_II on renin production by rat adrenal glomerulosa cells in culture .
15023936	0	angiotensin_II	79,93	renin	61,66	angiotensin II	renin	183	5972	Gene	Gene	blockade|amod|START_ENTITY phenotyping|nmod|blockade phenotyping|dobj|response response|compound|END_ENTITY	Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin_II blockade in humans .
15644940	0	angiotensin_II	50,64	renin	14,19	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	tetradecapeptide|nmod|START_ENTITY substrate|xcomp|tetradecapeptide substrate|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion of renin substrate tetradecapeptide to angiotensin_II by rat MAB elastase-2 .
15901242	0	angiotensin_II	11,25	renin	45,50	angiotensin II	renin	183	5972	Gene	Gene	Failure|nmod|START_ENTITY Failure|acl|suppress suppress|dobj|activity activity|compound|END_ENTITY	Failure of angiotensin_II to suppress plasma renin activity in normotensive subjects with a positive family history of hypertension .
16344366	0	angiotensin_II	62,76	renin	31,36	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	link|nmod|START_ENTITY H|dep|link H|amod|oxidase oxidase|nmod|hypertension hypertension|compound|END_ENTITY	Reduced NAD -LRB- P -RRB- H oxidase in low renin hypertension : link among angiotensin_II , atherogenesis , and blood pressure .
176034	0	angiotensin_II	138,152	renin	30,35	angiotensin II	renin	183	5972	Gene	Gene	infusion|nmod|START_ENTITY induced|nmod|infusion induced|nsubj|Effect Effect|nmod|aldosterone aldosterone|appos|activity activity|compound|END_ENTITY	Effect on plasma aldosterone , renin activity and cortisol of acute volume depletion induced by ethacrynic_acid under constant infusion of angiotensin_II and dexamethasone in man .
1856110	0	angiotensin_II	36,50	renin	12,17	angiotensin II	renin	183	5972	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of renin , angiotensinogen , angiotensin_II in the lamb anterior pituitary gland : immunocytochemical study after cryoultramicrotomy .
2171863	0	angiotensin_II	9,23	renin	71,76	angiotensin II	renin	183	5972	Gene	Gene	renin|nsubj|START_ENTITY renin|dobj|substrate substrate|compound|END_ENTITY	Platelet angiotensin_II binding and plasma renin concentration , plasma renin substrate and plasma angiotensin_II in human pregnancy .
21865264	0	angiotensin_II	63,77	renin	10,15	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|excretion excretion|compound|END_ENTITY	Increased renin excretion is associated with augmented urinary angiotensin_II levels in chronic angiotensin_II-infused hypertensive rats .
22222314	0	angiotensin_II	94,108	renin	61,66	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY inhibition|nmod|receptors inhibition|compound|END_ENTITY	Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin_II receptors in mRen2.Lewis hypertensive rats .
2447408	0	angiotensin_II	49,63	renin	32,37	angiotensin II	renin	183	5972	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of captopril-induced renin release by angiotensin_II .
2537331	0	angiotensin_II	24,38	renin	58,63	angiotensin II	renin	183	5972	Gene	Gene	effect|nmod|START_ENTITY infusion|nsubj|effect infusion|nmod|levels levels|compound|END_ENTITY	No effect of short term angiotensin_II infusion on plasma renin substrate levels in man .
26268270	0	angiotensin_II	75,89	renin	105,110	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	PKC-a-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin_II stimulation of renin in the collecting_duct .
26377797	0	angiotensin_II	21,35	renin	55,60	angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|acl|collecting collecting|dobj|synthesis synthesis|compound|END_ENTITY	Reciprocal effect of angiotensin_II in collecting duct renin synthesis .
2843564	0	angiotensin_II	96,110	renin	12,17	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	adrenal|nmod|START_ENTITY adrenal|nsubj|Presence Presence|nmod|granules granules|amod|END_ENTITY	Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin_II but not by adrenocorticotropin .
2843564	0	angiotensin_II	96,110	renin	77,82	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	adrenal|nmod|START_ENTITY adrenal|dobj|gland gland|nmod|secretion secretion|compound|END_ENTITY	Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin_II but not by adrenocorticotropin .
2852078	0	angiotensin_II	13,27	renin	66,71	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|synthesis synthesis|compound|END_ENTITY	Influence of angiotensin_II -LRB- AII -RRB- and angiotensin_I -LRB- AI -RRB- on renal renin synthesis and release .
3895792	0	angiotensin_II	89,103	renin	127,132	angiotensin II	renin	183	5972	Gene	Gene	concentrations|amod|START_ENTITY Relationships|appos|concentrations Relationships|appos|activity activity|compound|END_ENTITY	Relationships between blood pressure , heart rate and plasma epinephrine , norepinephrine , angiotensin_II concentrations , plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension .
393505	0	angiotensin_II	14,28	renin	111,116	angiotensin II	renin	183	5972	Gene	Gene	antagonist|amod|START_ENTITY Effects|nmod|antagonist isoleucine|nsubj|Effects isoleucine|nmod|pressure pressure|appos|activity activity|compound|END_ENTITY	Effects of an angiotensin_II antagonist ; -LSB- sarcosine 1 , isoleucine 8 -RSB- angiotensin_II , on blood pressure , plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive subjects taking oral contraceptives .
393505	0	angiotensin_II	69,83	renin	111,116	angiotensin II	renin	183	5972	Gene	Gene	isoleucine|dobj|START_ENTITY isoleucine|nmod|pressure pressure|appos|activity activity|compound|END_ENTITY	Effects of an angiotensin_II antagonist ; -LSB- sarcosine 1 , isoleucine 8 -RSB- angiotensin_II , on blood pressure , plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive subjects taking oral contraceptives .
4119172	0	angiotensin_II	31,45	renin	14,19	angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|nsubj|renin renin|appos|substrate substrate|compound|END_ENTITY	Plasma renin , renin substrate , angiotensin_II , and aldosterone in hypertensive disease of pregnancy .
4156503	0	angiotensin_II	43,57	renin	7,12	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	blockade|nmod|START_ENTITY END_ENTITY|nmod|blockade	Plasma renin response to acute blockade of angiotensin_II in the anaesthetized rat .
429480	0	angiotensin_II	35,49	renin	71,76	angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|hypertension hypertension|amod|END_ENTITY	Enhanced adrenal responsiveness to angiotensin_II in patients with low renin essential hypertension .
4331508	0	angiotensin_II	60,74	renin	11,16	angiotensin II	renin	183	5972	Gene	Gene	effect|nmod|START_ENTITY Release|nmod|effect Release|nmod|END_ENTITY	Release of renin by human kidney slices , in vitro effect of angiotensin_II , norepinephrine and aldosterone .
4373995	0	angiotensin_II	72,86	renin	29,34	angiotensin II	renin	183	5972	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|activity activity|compound|END_ENTITY	A correlation between plasma renin activity and the pressor response to angiotensin_II .
613577	0	angiotensin_II	47,61	renin	15,20	angiotensin II	renin	183	5972	Gene	Gene	blockade|amod|START_ENTITY END_ENTITY|nmod|blockade	-LSB- Hemodynamics , renin and aldosterone following angiotensin_II blockade and sodium_chloride deficiency in hypertensive subjects -RSB- .
618602	0	angiotensin_II	32,46	renin	11,16	angiotensin II	renin	183	5972	Gene	Gene	suppression|nmod|START_ENTITY suppression|nsubj|Failure Failure|nmod|END_ENTITY	Failure of renin suppression by angiotensin_II in hypertension .
6400371	0	angiotensin_II	11,25	renin	43,48	angiotensin II	renin	183	5972	Gene	Gene	Failure|nmod|START_ENTITY Failure|acl|reduce reduce|dobj|activity activity|compound|END_ENTITY	Failure of angiotensin_II to reduce plasma renin activity in hypertensive pregnant women .
6400372	0	angiotensin_II	52,66	renin	131,136	angiotensin II	renin	183	5972	Gene	Gene	secretion|nmod|START_ENTITY secretion|dep|factors factors|acl|determining determining|dobj|ratio ratio|compound|END_ENTITY	Renal secretion of inactive renin and extraction of angiotensin_II in renal_artery_stenosis in man : factors determining renal vein renin ratio .
6400372	0	angiotensin_II	52,66	renin	28,33	angiotensin II	renin	183	5972	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Renal secretion of inactive renin and extraction of angiotensin_II in renal_artery_stenosis in man : factors determining renal vein renin ratio .
657448	0	angiotensin_II	24,38	renin	60,65	angiotensin II	renin	183	5972	Gene	Gene	response|nmod|START_ENTITY response|nmod|patients patients|nmod|hypertension hypertension|amod|END_ENTITY	The pressor response to angiotensin_II in patients with low renin essential hypertension .
6756705	0	angiotensin_II	59,73	renin	27,32	angiotensin II	renin	183	5972	Gene	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Plasma active and inactive renin in man during infusion of angiotensin_II with and without prior administration of nifedipine .
7018685	0	angiotensin_II	44,58	renin	74,79	angiotensin II	renin	183	5972	Gene	Gene	analog|amod|START_ENTITY effects|appos|analog effects|nmod|subgroups subgroups|compound|END_ENTITY	Hemodynamic effects of -LSB- Sar1 , Ile8 -RSB- AII , an angiotensin_II analog , in the renin subgroups of essential hypertension .
7047005	0	angiotensin_II	30,44	renin	91,96	angiotensin II	renin	183	5972	Gene	Gene	START_ENTITY|nmod|subjects subjects|nmod|hypertension hypertension|amod|END_ENTITY	Aldosterone responsiveness to angiotensin_II after sodium restriction in subjects with low renin essential hypertension .
7584907	0	angiotensin_II	38,52	renin	69,74	angiotensin II	renin	183	5972	Gene	Gene	generate|dobj|START_ENTITY generate|nmod|substrates substrates|amod|END_ENTITY	Human urinary kallikrein can generate angiotensin_II from homologous renin substrates .
7644529	0	angiotensin_II	103,117	renin	21,26	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	counteracted|nmod|START_ENTITY counteracted|nsubjpass|stimulation stimulation|nmod|expression expression|compound|END_ENTITY	Tonic stimulation of renin gene expression by nitric_oxide is counteracted by tonic inhibition through angiotensin_II .
7659950	0	angiotensin_II	33,47	renin	63,68	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY ZENECA_ZD8731|appos|antagonist effects|nmod|ZENECA_ZD8731 effects|nmod|expression expression|compound|END_ENTITY	The effects of ZENECA_ZD8731 , an angiotensin_II antagonist , on renin expression by juxtaglomerular cells in the rat : comparison of protein and mRNA expression as detected by immunohistochemistry and in situ hybridization .
7759857	0	angiotensin_II	125,139	renin	34,39	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	angiotensinogen|nmod|START_ENTITY stimulation|nmod|angiotensinogen evidence|nmod|stimulation depletion|dep|evidence depletion|nmod|levels levels|compound|END_ENTITY	Angiotensinogen depletion by high renin levels in hypertensive rats : no evidence for tonic stimulation of angiotensinogen by angiotensin_II .
7922810	0	angiotensin_II	30,44	renin	8,13	angiotensin II	renin	183	5972	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	-LSB- Plasma renin activity -LRB- PRA -RRB- , angiotensin_II -LRB- AII -RRB- , atrial natriuretic peptide -LRB- ANP -RRB- and AII/ANP ratio in severely burned patients -RSB- .
8031544	0	angiotensin_II	53,67	renin	19,24	angiotensin II	renin	183	5972	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|R-PEP-27 R-PEP-27|appos|inhibitor inhibitor|compound|END_ENTITY	R-PEP-27 , a potent renin inhibitor , decreases plasma angiotensin_II and blood pressure in normal volunteers .
8456103	0	angiotensin_II	33,47	renin	134,139	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY Effect|appos|antagonist Effect|acl|drinking drinking|dobj|actions actions|nmod|END_ENTITY	Effect of Losartan , a nonpeptide angiotensin_II receptor antagonist , on drinking behavior and renal actions of centrally administered renin .
8833654	0	angiotensin_II	35,49	renin	147,152	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|factor factor|dep|mechanism mechanism|nmod|loop loop|compound|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
886656	0	angiotensin_II	110,124	renin	78,83	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY END_ENTITY|nmod|antagonist	Role of renin-angiotensin system in experimental hypertension in rats : plasma renin and hypotensive effect of angiotensin_II antagonist .
9136670	0	angiotensin_II	12,26	renin	54,59	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	The role of angiotensin_II in the feedback control of renin gene expression .
9226634	0	angiotensin_II	54,68	renin	7,12	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	rate|nmod|START_ENTITY END_ENTITY|dobj|rate	Plasma renin activity and metabolic clearance rate of angiotensin_II in the unstressed aging rat .
9431853	0	angiotensin_II	70,84	renin	54,59	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	blockade|amod|START_ENTITY Role|nmod|blockade Role|nmod|stimulation stimulation|nmod|system system|compound|END_ENTITY	Role of sympathetic nerves for the stimulation of the renin system by angiotensin_II receptor blockade .
9440700	0	angiotensin_II	6,20	renin	58,63	angiotensin II	renin	24179(Tax:10116)	24715(Tax:10116)	Gene	Gene	generation|compound|START_ENTITY generation|dep|role role|nmod|uptake uptake|compound|END_ENTITY	Local angiotensin_II generation in the rat heart : role of renin uptake .
9740600	0	angiotensin_II	13,27	renin	125,130	angiotensin II	renin	183	5972	Gene	Gene	generation|amod|START_ENTITY Pathways|nmod|generation Pathways|dep|evidence evidence|nmod|interruption interruption|nmod|system system|compound|END_ENTITY	Pathways for angiotensin_II generation in intact human tissue : evidence from comparative pharmacological interruption of the renin system .
26804998	0	angiotensin_II	52,66	rho-kinase	89,99	angiotensin II	rho-kinase	11606(Tax:10090)	19878(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	Methylmercury affects cerebrovascular reactivity to angiotensin_II and acetylcholine via rho-kinase and nitric_oxide pathways in mice .
11530112	0	angiotensin_II	63,77	thrombospondin-1	27,43	angiotensin II	thrombospondin-1	24179(Tax:10116)	445442(Tax:10116)	Gene	Gene	subtypes|amod|START_ENTITY regulation|nmod|subtypes regulation|nmod|END_ENTITY	Differential regulation of thrombospondin-1 and fibronectin by angiotensin_II receptor subtypes in cultured endothelial cells .
17640965	0	angiotensin_II	133,147	thrombospondin-1	2,18	angiotensin II	thrombospondin-1	24179(Tax:10116)	445442(Tax:10116)	Gene	Gene	rats|nmod|START_ENTITY transforming|nmod|rats antagonist|acl|transforming antagonist|amod|END_ENTITY	A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin_II .
9223624	0	angiotensin_II	45,59	thrombospondin-1	14,30	angiotensin II	thrombospondin-1	24179(Tax:10116)	445442(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|amod|END_ENTITY	Regulation of thrombospondin-1 production by angiotensin_II in rat heart endothelial cells .
17460566	0	angiotensin_II	13,27	toll-like_receptor_2	45,65	angiotensin II	toll-like receptor 2	24179(Tax:10116)	310553(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of angiotensin_II on expression of toll-like_receptor_2 and maturation of dendritic cells in chronic cyclosporine nephropathy .
7492983	0	angiotensin_II	8,22	transforming_growth_factor-beta_1	30,63	angiotensin II	transforming growth factor-beta 1	24179(Tax:10116)	59086(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Role of angiotensin_II in the transforming_growth_factor-beta_1 expression of rat kidney in anti-glomerular basement membrane antiserum-induced glomerulonephritis .
8806891	0	angiotensin_II	82,96	tumor_necrosis_factor	11,32	angiotensin II	tumor necrosis factor	24179(Tax:10116)	103694380	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor and interleukin-1 on the constriction induced by angiotensin_II in rat aorta .
14519430	0	angiotensin_II	64,78	tumor_necrosis_factor-alpha	24,51	angiotensin II	tumor necrosis factor-alpha	183	7124	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Regulation of the human tumor_necrosis_factor-alpha promoter by angiotensin_II and lipopolysaccharide in cardiac fibroblasts : different cis-acting promoter sequences and transcriptional factors .
10203356	0	angiotensin_II	15,29	vascular_endothelial_growth_factor	56,90	angiotensin II	vascular endothelial growth factor	183	7422	Gene	Gene	Interaction|nmod|START_ENTITY stretch|nsubj|Interaction stretch|nmod|production production|compound|END_ENTITY	Interaction of angiotensin_II and mechanical stretch on vascular_endothelial_growth_factor production by human mesangial cells .
15572520	0	angiotensin_II	103,117	vascular_endothelial_growth_factor	28,62	angiotensin II	vascular endothelial growth factor	183	7422	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Translational regulation of vascular_endothelial_growth_factor expression in renal epithelial cells by angiotensin_II .
16085213	0	angiotensin_II	19,33	vascular_endothelial_growth_factor	37,71	angiotensin II	vascular endothelial growth factor	183	7422	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Essential roles of angiotensin_II in vascular_endothelial_growth_factor expression in sleep_apnea_syndrome .
17581920	0	angiotensin_II	57,71	vascular_endothelial_growth_factor	87,121	angiotensin II	vascular endothelial growth factor	183	7422	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|translation translation|compound|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_K contributes to angiotensin_II stimulation of vascular_endothelial_growth_factor mRNA translation .
22382381	0	angiotensin_II	114,128	vascular_endothelial_growth_factor	24,58	angiotensin II	vascular endothelial growth factor	183	7422	Gene	Gene	synergy|nmod|START_ENTITY fibroblasts|nmod|synergy stimulates|nmod|fibroblasts stimulates|dobj|secretion secretion|compound|END_ENTITY	Urotensin_II stimulates vascular_endothelial_growth_factor secretion from adventitial fibroblasts in synergy with angiotensin_II .
9531974	0	angiotensin_II	54,68	vascular_endothelial_growth_factor	16,50	angiotensin II	vascular endothelial growth factor	24179(Tax:10116)	83785(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor by angiotensin_II in rat heart endothelial cells .
9797192	0	angiotensin_II	98,112	vascular_type_1_angiotensin_II_receptor	14,53	angiotensin II	vascular type 1 angiotensin II receptor	24179(Tax:10116)	24180(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|END_ENTITY	Regulation of vascular_type_1_angiotensin_II_receptor in hypertension and sodium loading : role of angiotensin_II .
16158334	0	angiotensin_II-induced_SP-1_and_AP-1	32,68	Oct-1	84,89	angiotensin II-induced SP-1 and AP-1	Oct-1	24516(Tax:10116)	24904(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Heat_shock treatment suppresses angiotensin_II-induced_SP-1_and_AP-1 and stimulates Oct-1 DNA-binding activity in heart .
15034006	0	angiotensin_II_receptor_subtype_2	49,82	AT2	84,87	angiotensin II receptor subtype 2	AT2	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical and mRNA localization of the angiotensin_II_receptor_subtype_2 -LRB- AT2 -RRB- in follicular granulosa cells of the rat ovary .
27050965	0	angiotensin_II_receptor_type_1	78,108	AGTR1	110,115	angiotensin II receptor type 1	AGTR1	185	185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of correlations between coronary_heart_disease and haplotypes of the angiotensin_II_receptor_type_1 -LRB- AGTR1 -RRB- gene .
22264484	0	angiotensin_II_receptor_type_1	104,134	AT1	136,139	angiotensin II receptor type 1	AT1	81638(Tax:10116)	81638(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and antihypertensive activity of pyrimidin-4 -LRB- 3H -RRB- - one derivatives as losartan analogue for new angiotensin_II_receptor_type_1 -LRB- AT1 -RRB- antagonists .
23845221	0	angiotensin_II_receptor_type_1	87,117	AT1	119,122	angiotensin II receptor type 1	AT1	185	185	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Development of 3D-QSAR CoMSIA models for 5 - -LRB- biphenyl-2-yl -RRB- -1 H-tetrazole derivatives as angiotensin_II_receptor_type_1 -LRB- AT1 -RRB- antagonists .
23273598	0	angiotensin_II_receptor_type_1	86,116	AT1-R	118,123	angiotensin II receptor type 1	AT1-R	185	185	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Correlation between VEGFR-2 receptor kinase domain-containing receptor -LRB- KDR -RRB- mRNA and angiotensin_II_receptor_type_1 -LRB- AT1-R -RRB- mRNA in endometrial_cancer .
10738546	0	angiotensin_II_subtype_1	63,87	AT1	89,92	angiotensin II subtype 1	AT1	185	185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of polymorphisms in the promoter of the human angiotensin_II_subtype_1 -LRB- AT1 -RRB- receptor gene .
12897082	0	angiotensin_II_subtype_1	37,61	AT1	63,66	angiotensin II subtype 1	AT1	11607(Tax:10090)	11607(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Cyclosporin increases the density of angiotensin_II_subtype_1 -LRB- AT1 -RRB- receptors in mouse medullary thick ascending limb cells .
21321983	0	angiotensin_II_type-1_receptor	32,62	Akt	15,18	angiotensin II type-1 receptor	Akt	81638(Tax:10116)	24185(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Phosphorylated Akt up-regulates angiotensin_II_type-1_receptor expression in castration resistant prostate_cancer .
15733910	0	angiotensin_II_type_1	34,55	AT1	57,60	angiotensin II type 1	AT1	24180(Tax:10116)	24180(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	IL-1beta and TNF-alpha upregulate angiotensin_II_type_1 -LRB- AT1 -RRB- receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart .
18927221	0	angiotensin_II_type_1A_receptor	70,101	megalin	14,21	angiotensin II type 1A receptor	megalin	24180(Tax:10116)	29216(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Regulation of megalin expression in cultured proximal tubule cells by angiotensin_II_type_1A_receptor - and insulin-mediated signaling cross talk .
23484035	0	angiotensin_II_type_1_receptor	49,79	AGTR1	81,86	angiotensin II type 1 receptor	AGTR1	185	185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Susceptibility and gene interaction study of the angiotensin_II_type_1_receptor -LRB- AGTR1 -RRB- gene polymorphisms with non-alcoholic_fatty_liver_disease in a multi-ethnic population .
21412239	0	angiotensin_II_type_1_receptor	33,63	APJ	14,17	angiotensin II type 1 receptor	APJ	185	187	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	Non-activated APJ suppresses the angiotensin_II_type_1_receptor , whereas apelin-activated APJ acts conversely .
17710578	0	angiotensin_II_type_1_receptor	63,93	AT1R	95,99	angiotensin II type 1 receptor	AT1R	185	185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Angiotensin-converting enzyme insertion/deletion -LRB- ACE I/D -RRB- and angiotensin_II_type_1_receptor -LRB- AT1R -RRB- gene polymorphism and its association with preeclampsia in Chinese women .
19162259	0	angiotensin_II_type_1_receptor	64,94	AT1R	96,100	angiotensin II type 1 receptor	AT1R	185	185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Angiotensin-converting enzyme -LRB- ACE -RRB- , angiotensinogen -LRB- AGT -RRB- , and angiotensin_II_type_1_receptor -LRB- AT1R -RRB- gene polymorphisms in generalized aggressive periodontitis .
24321324	0	angiotensin_II_type_1_receptor	14,44	BRCA1	96,101	angiotensin II type 1 receptor	BRCA1	185	672	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of angiotensin_II_type_1_receptor expression in ovarian_cancer : a potential role for BRCA1 .
24452940	0	angiotensin_II_type_1_receptor	79,109	Endothelial_constitutive_nitric_oxide_synthase	0,46	angiotensin II type 1 receptor	Endothelial constitutive nitric oxide synthase	185	4846	Gene	Gene	polymorphisms|amod|START_ENTITY END_ENTITY|appos|polymorphisms	Endothelial_constitutive_nitric_oxide_synthase , angiotensin_converting_enzyme , angiotensin_II_type_1_receptor gene polymorphisms and endothelial functions in healthy individuals .
16675453	0	angiotensin_II_type_1_receptor	29,59	MicroRNA-155	0,12	angiotensin II type 1 receptor	MicroRNA-155	185	406947	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-155 regulates human angiotensin_II_type_1_receptor expression in fibroblasts .
20735984	0	angiotensin_II_type_1_receptor	23,53	MicroRNA-155	0,12	angiotensin II type 1 receptor	MicroRNA-155	81638(Tax:10116)	102465831	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-155 regulates angiotensin_II_type_1_receptor expression and phenotypic differentiation in vascular adventitial fibroblasts .
21541973	0	angiotensin_II_type_1_receptor	51,81	androgen_receptor	14,31	angiotensin II type 1 receptor	androgen receptor	11610(Tax:10090)	11835(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of androgen_receptor expression through angiotensin_II_type_1_receptor in prostate_cancer cells .
24452940	0	angiotensin_II_type_1_receptor	79,109	angiotensin_converting_enzyme	48,77	angiotensin II type 1 receptor	angiotensin converting enzyme	185	1636	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Endothelial_constitutive_nitric_oxide_synthase , angiotensin_converting_enzyme , angiotensin_II_type_1_receptor gene polymorphisms and endothelial functions in healthy individuals .
17982475	0	angiotensin_II_type_1_receptor	23,53	insulin	59,66	angiotensin II type 1 receptor	insulin	185	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Functional coupling of angiotensin_II_type_1_receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes -LRB- HL-1 cells -RRB- .
20558762	0	angiotensin_II_type_1_receptor	24,54	miR-802	0,7	angiotensin II type 1 receptor	miR-802	185	768219	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-802 regulates human angiotensin_II_type_1_receptor expression in intestinal epithelial C2BBe1 cells .
25953323	0	angiotensin_II_type_2_receptor	42,72	AT2R	74,78	angiotensin II type 2 receptor	AT2R	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	b-Pro7Ang III is a novel highly selective angiotensin_II_type_2_receptor -LRB- AT2R -RRB- agonist , which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats .
25953323	0	angiotensin_II_type_2_receptor	42,72	AT2R	74,78	angiotensin II type 2 receptor	AT2R	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	b-Pro7Ang III is a novel highly selective angiotensin_II_type_2_receptor -LRB- AT2R -RRB- agonist , which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats .
26186568	0	angiotensin_II_type_2_receptor	42,72	AT2R	74,78	angiotensin II type 2 receptor	AT2R	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	b-Pro7Ang III is a novel highly selective angiotensin_II_type_2_receptor -LRB- AT2R -RRB- agonist , which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats .
9115258	0	angiotensin_II_type_2_receptor	44,74	Interferon_regulatory_factor-1	0,30	angiotensin II type 2 receptor	Interferon regulatory factor-1	11609(Tax:10090)	16362(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Interferon_regulatory_factor-1 up-regulates angiotensin_II_type_2_receptor and induces apoptosis .
10085710	0	angiotensin_I_converting_enzyme	165,196	ACE	197,200	angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Lack of relationship between angiotensinogen gene m235t polymorphism and gene insertion/deletion -LRB- I/D-intron 16 -RRB- and Pst I RFLP -LRB- P/M-intron 7 -RRB- polymorphisms of the angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene and the development of H-gestosis .
15883972	0	angiotensin_I_converting_enzyme	83,114	ACE	116,119	angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Domain-selective ligand-binding modes and atomic level pharmacophore refinement in angiotensin_I_converting_enzyme -LRB- ACE -RRB- inhibitors .
16496609	0	angiotensin_I_converting_enzyme	42,73	ACE	75,78	angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The influence of I/D polymorphism of the angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene and 4G/5G polymorphism of plasminogen activator inhibitor -LRB- PAI-1 -RRB- gene promoter on the haemostatic system in patients with essential hypertension and dyslipidemia -RSB- .
21928698	0	angiotensin_I_converting_enzyme	23,54	ACE	56,59	angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	No association between angiotensin_I_converting_enzyme -LRB- ACE -RRB- I/D polymorphism and gastric_cancer risk among Japanese .
2829599	0	angiotensin_I_converting_enzyme	11,42	ACE	44,47	angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of angiotensin_I_converting_enzyme -LRB- ACE -RRB- related substances upon the vascular prostacyclin generation .
7696999	0	angiotensin_I_converting_enzyme	44,75	ACE	77,80	angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequencies of the angiotensinogen gene and angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene polymorphisms in African Americans .
8795663	0	angiotensin_I_converting_enzyme	29,60	ACE	62,65	angiotensin I converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion polymorphism in the angiotensin_I_converting_enzyme -LRB- ACE -RRB- gene as a genetic risk factor for sarcoidosis .
2557706	0	angiotensin_I_converting_enzyme	37,68	AICE	70,74	angiotensin I converting enzyme	AICE	610668(Tax:9615)	610668(Tax:9615)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Effect of paraquat on serum and lung angiotensin_I_converting_enzyme -LRB- AICE -RRB- activity in beagle_dogs .
3034844	0	angiotensin_I_converting_enzyme	27,58	K-13	0,4	angiotensin I converting enzyme	K-13	24310(Tax:10116)	287699(Tax:10116)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	K-13 , a novel inhibitor of angiotensin_I_converting_enzyme produced by Micromonospora halophytica subsp .
3034845	0	angiotensin_I_converting_enzyme	27,58	K-13	0,4	angiotensin I converting enzyme	K-13	1636	3860	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	K-13 , a novel inhibitor of angiotensin_I_converting_enzyme produced by Micromonospora halophytica subsp .
3005218	0	angiotensin_I_converting_enzyme	27,58	K-26	0,4	angiotensin I converting enzyme	K-26	1636	353288	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	K-26 , a novel inhibitor of angiotensin_I_converting_enzyme produced by an actinomycete K-26 .
3009378	0	angiotensin_I_converting_enzyme	26,57	K-4	0,3	angiotensin I converting enzyme	K-4	24310(Tax:10116)	315323(Tax:10116)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	K-4 , a novel inhibitor of angiotensin_I_converting_enzyme produced by Actinomadura spiculosospora .
1318793	0	angiotensin_I_converting_enzyme	67,98	bradykinin	53,63	angiotensin I converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin_I_converting_enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors .
10544843	0	angiotensin_converting_enzyme	92,121	ACE	123,126	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between systemic_lupus_erythematosus and insertion/deletion polymorphism of the angiotensin_converting_enzyme -LRB- ACE -RRB- gene .
10624863	0	angiotensin_converting_enzyme	39,68	ACE	70,73	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Screening of Zulu medicinal plants for angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
10682664	0	angiotensin_converting_enzyme	61,90	ACE	92,95	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the insertion/deletion polymorphism of the human angiotensin_converting_enzyme -LRB- ACE -RRB- gene in patients with renal_cancer .
10868493	0	angiotensin_converting_enzyme	13,42	ACE	44,47	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of angiotensin_converting_enzyme -LRB- ACE -RRB- genotype on interpretation of diagnostic tests for serum ACE activity .
10874368	0	angiotensin_converting_enzyme	15,44	ACE	46,49	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of angiotensin_converting_enzyme -LRB- ACE -RRB- gene polymorphism with hypertension in a Bangladeshi population .
10976394	0	angiotensin_converting_enzyme	16,45	ACE	47,50	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Proteinuria and angiotensin_converting_enzyme -LRB- ACE -RRB- gene polymorphism .
10983838	0	angiotensin_converting_enzyme	94,123	ACE	125,128	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Poor regression of myocardial_hypertrophy following concomitant chronic alcohol ingestion and angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition .
11806030	0	angiotensin_converting_enzyme	17,46	ACE	48,51	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	-LSB- Significance of angiotensin_converting_enzyme -LRB- ACE -RRB- in coronary circulation -RSB- .
12477155	0	angiotensin_converting_enzyme	54,83	ACE	85,88	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Therapeutic controversies in hypertension management : angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors or angiotensin receptor blockers for diabetic_nephropathy ?
12767053	0	angiotensin_converting_enzyme	35,64	ACE	66,69	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Modulation of metabolic control by angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition .
12803241	0	angiotensin_converting_enzyme	36,65	ACE	31,34	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|nmod|END_ENTITY	The higher immunoreactivity to ACE -LRB- angiotensin_converting_enzyme -RRB- in patients with type_2_diabetes_mellitus than in non-diabetic individuals .
14675780	0	angiotensin_converting_enzyme	14,43	ACE	45,48	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of angiotensin_converting_enzyme -LRB- ACE -RRB- activity by flavan-3-ols and procyanidins .
1536695	0	angiotensin_converting_enzyme	19,48	ACE	50,53	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Adverse effects of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
15724789	0	angiotensin_converting_enzyme	54,83	ACE	85,88	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Therapeutic controversies in hypertension management : angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors or angiotensin receptor blockers in diabetic_nephropathy ?
16901062	0	angiotensin_converting_enzyme	12,41	ACE	43,46	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- The use of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors during pregnancy clearly increases the risk of congenital_malformations -RSB- .
17123697	0	angiotensin_converting_enzyme	60,89	ACE	91,94	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The influence of mode of delivery and ACE genotype on serum angiotensin_converting_enzyme -LRB- ACE -RRB- activity in the mother and infant at term .
17163998	0	angiotensin_converting_enzyme	77,106	ACE	108,111	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of significant association of an insertion/deletion polymorphism in the angiotensin_converting_enzyme -LRB- ACE -RRB- gene with tropical_calcific_pancreatitis .
17520798	0	angiotensin_converting_enzyme	19,48	ACE	50,53	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association of angiotensin_converting_enzyme -LRB- ACE -RRB- polymorphisms with sleep_apnea and hypertension .
17875387	0	angiotensin_converting_enzyme	29,58	ACE	60,63	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Garlic extract reduces serum angiotensin_converting_enzyme -LRB- ACE -RRB- activity in nondiabetic and streptozotocin-diabetic rats .
18036585	0	angiotensin_converting_enzyme	26,55	ACE	57,60	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Therapeutic resistance to angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition is related to pharmacodynamic and - kinetic factors in 5/6 nephrectomized rats .
18843651	0	angiotensin_converting_enzyme	36,65	ACE	67,70	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Blood pressure lowering efficacy of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors for primary hypertension .
21688035	0	angiotensin_converting_enzyme	26,55	ACE	57,60	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Individualised therapy of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors in stable coronary_artery_disease : overview of the primary results of the PERindopril GENEtic association -LRB- PERGENE -RRB- study .
21782455	0	angiotensin_converting_enzyme	105,134	ACE	136,139	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
21939743	0	angiotensin_converting_enzyme	15,44	ACE	46,49	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of angiotensin_converting_enzyme -LRB- ACE -RRB- gene I/D polymorphism and polycystic_ovary_syndrome -LRB- PCOS -RRB- .
2199299	0	angiotensin_converting_enzyme	45,74	ACE	76,79	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Does kinin mediate the hypotensive action of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors ?
22808171	0	angiotensin_converting_enzyme	32,61	ACE	63,66	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA methylation analysis of the angiotensin_converting_enzyme -LRB- ACE -RRB- gene in major_depression .
23000565	0	angiotensin_converting_enzyme	15,44	ACE	46,49	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of angiotensin_converting_enzyme -LRB- ACE -RRB- gene I/D polymorphism and rheumatoid_arthritis .
23183619	0	angiotensin_converting_enzyme	84,113	ACE	115,118	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Attenuation of focal cerebral ischemic_injury following post-ischemic inhibition of angiotensin_converting_enzyme -LRB- ACE -RRB- activity in normotensive rat .
23409414	0	angiotensin_converting_enzyme	26,55	ACE	57,60	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hypertension subtypes and angiotensin_converting_enzyme -LRB- ACE -RRB- gene polymorphism in Indian population .
23743058	0	angiotensin_converting_enzyme	118,147	ACE	149,152	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Isolation , identification and molecular docking studies of a new isolated compound , from Onopordon_acanthium : a novel angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor .
23777825	0	angiotensin_converting_enzyme	104,133	ACE	135,138	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design , synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5 ,11 - dione analogues as potent angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
2382917	0	angiotensin_converting_enzyme	75,104	ACE	106,109	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Outcome of renal_crisis in systemic_sclerosis : relation to availability of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
2402813	0	angiotensin_converting_enzyme	42,71	ACE	73,76	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	-LSB- Side effects in 28 patients treated with angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor in arterial hypertension in general practice -RSB- .
2422495	0	angiotensin_converting_enzyme	14,43	ACE	45,48	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of angiotensin_converting_enzyme -LRB- ACE -RRB- in the pharmacokinetics and pharmacodynamics of ACE inhibitors .
24691160	0	angiotensin_converting_enzyme	82,111	ACE	113,116	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	New perspectives in the renin-angiotensin-aldosterone system -LRB- RAAS -RRB- I : endogenous angiotensin_converting_enzyme -LRB- ACE -RRB- inhibition .
25300819	0	angiotensin_converting_enzyme	100,129	ACE	131,134	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and evaluation of novel triazoles and mannich bases functionalized 1,4-dihydropyridine as angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
25332829	0	angiotensin_converting_enzyme	17,46	ACE	48,51	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A pilot study of angiotensin_converting_enzyme -LRB- ACE -RRB- genotype and return of spontaneous circulation following out-of-hospital cardiac_arrest .
25603633	0	angiotensin_converting_enzyme	34,63	ACE	65,68	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Small_bowel_angioedema induced by angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor : US and CT findings .
2829597	0	angiotensin_converting_enzyme	11,40	ACE	42,45	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Changes of angiotensin_converting_enzyme -LRB- ACE -RRB- levels during activation of the renin-angiotensin-aldosterone system -LRB- RAAs -RRB- .
2838262	0	angiotensin_converting_enzyme	20,49	ACE	51,54	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of angiotensin_converting_enzyme -LRB- ACE -RRB- in the testis and assessment of the in vivo effects of the ACE inhibitor perindopril .
3033786	0	angiotensin_converting_enzyme	18,47	ACE	49,52	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of the angiotensin_converting_enzyme -LRB- ACE -RRB- in cultures of rat peritoneal macrophages .
3034521	0	angiotensin_converting_enzyme	24,53	ACE	55,58	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Circadian rhythm of the angiotensin_converting_enzyme -LRB- ACE -RRB- activity in serum of healthy adult subjects .
6182819	0	angiotensin_converting_enzyme	49,78	ACE	80,83	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Characteristics , assay and semeiologic value of angiotensin_converting_enzyme -LRB- ACE -RRB- -RSB- .
8448584	0	angiotensin_converting_enzyme	26,55	ACE	57,60	angiotensin converting enzyme	ACE	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Dose-dependent effects of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors on glomerular prostanoid production by normotensive rats .
8677193	0	angiotensin_converting_enzyme	13,42	ACE	44,47	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	-LSB- Analysis of angiotensin_converting_enzyme -LRB- ACE -RRB- polymorphism in patients with myocardial_infarction in the Polish population -RSB- .
9222960	0	angiotensin_converting_enzyme	100,129	ACE	131,134	angiotensin converting enzyme	ACE	1636	1636	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Congenital renal_tubular_dysplasia and skull ossification defects similar to teratogenic effects of angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitors .
9246391	0	angiotensin_converting_enzyme	12,41	ACE	43,46	angiotensin converting enzyme	ACE	613133(Tax:9823)	613133(Tax:9823)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Presence of angiotensin_converting_enzyme -LRB- ACE -RRB- activity in serum of amphibian : comparison with ACE activity of mammalian serum .
9447482	0	angiotensin_converting_enzyme	64,93	ACE	95,98	angiotensin converting enzyme	ACE	610668(Tax:9615)	610668(Tax:9615)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Treatment of X-linked_hereditary_nephritis in Samoyed dogs with angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor .
26380810	0	angiotensin_converting_enzyme	71,100	AnCE	112,116	angiotensin converting enzyme	AnCE	34805(Tax:7227)	34805(Tax:7227)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	A new high-resolution crystal structure of the Drosophila_melanogaster angiotensin_converting_enzyme homologue , AnCE .
12028132	0	angiotensin_converting_enzyme	30,59	Bradykinin	0,10	angiotensin converting enzyme	Bradykinin	1636	3827	Gene	Gene	modulation|amod|START_ENTITY involved|nmod|modulation involved|nsubjpass|END_ENTITY	Bradykinin is not involved in angiotensin_converting_enzyme modulation of ovarian steroidogenesis and prostaglandin production in frog Rana esculenta .
2153061	0	angiotensin_converting_enzyme	54,83	Bradykinin	0,10	angiotensin converting enzyme	Bradykinin	610668(Tax:9615)	478666(Tax:9615)	Gene	Gene	inhibitor|amod|START_ENTITY contribution|nmod|inhibitor contribution|compound|END_ENTITY	Bradykinin contribution to renal_blood_flow effect of angiotensin_converting_enzyme inhibitor in the conscious sodium-restricted dog .
3025487	0	angiotensin_converting_enzyme	14,43	CV-3317	47,54	angiotensin converting enzyme	CV-3317	24310(Tax:10116)	2549020(Tax:243365)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_converting_enzyme by CV-3317 , a non-sulfhydryl compound .
24452940	0	angiotensin_converting_enzyme	48,77	Endothelial_constitutive_nitric_oxide_synthase	0,46	angiotensin converting enzyme	Endothelial constitutive nitric oxide synthase	1636	4846	Gene	Gene	polymorphisms|amod|START_ENTITY END_ENTITY|appos|polymorphisms	Endothelial_constitutive_nitric_oxide_synthase , angiotensin_converting_enzyme , angiotensin_II_type_1_receptor gene polymorphisms and endothelial functions in healthy individuals .
2545578	0	angiotensin_converting_enzyme	92,121	MK-0521	80,87	angiotensin converting enzyme	MK-0521	24310(Tax:10116)	1476622(Tax:190192)	Gene	Gene	L-lysyl-L-proline|nmod|START_ENTITY L-lysyl-L-proline|appos|END_ENTITY	-LSB- Inhibitory effect of N-alpha - -LSB- -LRB- S -RRB- -1 - carboxy-3-phenylpropyl -RSB- - L-lysyl-L-proline -LRB- MK-0521 -RRB- on angiotensin_converting_enzyme in vitro -RSB- .
2162881	0	angiotensin_converting_enzyme	38,67	Platelet-activating_factor	0,26	angiotensin converting enzyme	Platelet-activating factor	1636	9768	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	Platelet-activating_factor stimulates angiotensin_converting_enzyme activity .
24452940	0	angiotensin_converting_enzyme	48,77	angiotensin_II_type_1_receptor	79,109	angiotensin converting enzyme	angiotensin II type 1 receptor	1636	185	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Endothelial_constitutive_nitric_oxide_synthase , angiotensin_converting_enzyme , angiotensin_II_type_1_receptor gene polymorphisms and endothelial functions in healthy individuals .
2165961	0	angiotensin_converting_enzyme	121,150	angiotensin_converting_enzyme	26,55	angiotensin converting enzyme	angiotensin converting enzyme	1636	1636	Gene	Gene	activity|nmod|START_ENTITY inhibitor|nmod|activity inhibitor|nsubj|END_ENTITY	Effect of SQ29 ,852 , a new angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor with a phosphonic_acid group , on the activity of angiotensin_converting_enzyme from human kidney .
2165961	0	angiotensin_converting_enzyme	26,55	angiotensin_converting_enzyme	121,150	angiotensin converting enzyme	angiotensin converting enzyme	1636	1636	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|activity activity|nmod|END_ENTITY	Effect of SQ29 ,852 , a new angiotensin_converting_enzyme -LRB- ACE -RRB- inhibitor with a phosphonic_acid group , on the activity of angiotensin_converting_enzyme from human kidney .
2170515	0	angiotensin_converting_enzyme	39,68	atrial_natriuretic_factor	10,35	angiotensin converting enzyme	atrial natriuretic factor	1636	4878	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on angiotensin_converting_enzyme .
10821135	0	angiotensin_converting_enzyme	66,95	bradykinin	124,134	angiotensin converting enzyme	bradykinin	610668(Tax:9615)	478666(Tax:9615)	Gene	Gene	inhibitors|nmod|START_ENTITY afforded|nmod|inhibitors cardioprotection|acl|afforded mechanisms|nmod|cardioprotection mechanisms|dep|role role|nmod|END_ENTITY	Cellular mechanisms of cardioprotection afforded by inhibitors of angiotensin_converting_enzyme in ischemic hearts : role of bradykinin and nitric_oxide .
1480537	0	angiotensin_converting_enzyme	88,117	bradykinin	60,70	angiotensin converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibitor|compound|START_ENTITY intradermal|nmod|inhibitor intradermal|dobj|END_ENTITY	Absence of potentiation of the skin response to intradermal bradykinin by a long-acting angiotensin_converting_enzyme inhibitor , trandolapril , at conventional antihypertensive dosage in human volunteers : a double-blind , randomized , cross-over , placebo-controlled trial .
2541753	0	angiotensin_converting_enzyme	57,86	bradykinin	27,37	angiotensin converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibitors|amod|START_ENTITY potentiated|nmod|inhibitors potentiated|nsubjpass|effects effects|nmod|END_ENTITY	The effects of intradermal bradykinin are potentiated by angiotensin_converting_enzyme inhibitors in hypertensive patients .
3034372	0	angiotensin_converting_enzyme	54,83	bradykinin	23,33	angiotensin converting enzyme	bradykinin	1636	3827	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of intradermal bradykinin after inhibition of angiotensin_converting_enzyme .
8930174	0	angiotensin_converting_enzyme	24,53	bradykinin	116,126	angiotensin converting enzyme	bradykinin	1636	3827	Gene	Gene	effects|nmod|START_ENTITY inhibitors|nsubj|effects inhibitors|nmod|END_ENTITY	Differential effects of angiotensin_converting_enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin .
9469636	0	angiotensin_converting_enzyme	61,90	bradykinin	16,26	angiotensin converting enzyme	bradykinin	1636	3827	Gene	Gene	inhibition|amod|START_ENTITY action|nmod|inhibition Contribution|nmod|action Contribution|nmod|END_ENTITY	Contribution of bradykinin to the cardioprotective action of angiotensin_converting_enzyme inhibition in hypertension and after myocardial_infarction .
25273883	0	angiotensin_converting_enzyme	13,42	miR-143	49,56	angiotensin converting enzyme	miR-143	11421(Tax:10090)	387161(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of angiotensin_converting_enzyme after miR-143 / 145 deletion is critical for impaired smooth muscle contractility .
1847704	0	angiotensin_converting_enzyme	22,51	renin	129,134	angiotensin converting enzyme	renin	1636	5972	Gene	Gene	activity|amod|START_ENTITY changes|nmod|activity Effects|nmod|changes enhances|nsubj|Effects enhances|dobj|response response|compound|END_ENTITY	Effects of changes in angiotensin_converting_enzyme activity on renin release : pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects .
1847704	0	angiotensin_converting_enzyme	22,51	renin	64,69	angiotensin converting enzyme	renin	1636	5972	Gene	Gene	activity|amod|START_ENTITY activity|nmod|release release|compound|END_ENTITY	Effects of changes in angiotensin_converting_enzyme activity on renin release : pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects .
21169387	0	angiotensin_converting_enzyme	63,92	renin	7,12	angiotensin converting enzyme	renin	1636	5972	Gene	Gene	inhibition|xcomp|START_ENTITY END_ENTITY|acl|inhibition	Direct renin inhibition in addition to or as an alternative to angiotensin_converting_enzyme inhibition in patients with chronic systolic heart_failure : rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart_failuRE -LRB- ATMOSPHERE -RRB- study .
24175935	0	angiotensin_converting_enzyme	24,53	renin	65,70	angiotensin converting enzyme	renin	100064801(Tax:9796)	100054248(Tax:9796)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Effects of quinapril on angiotensin_converting_enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite , quinaprilat , after intravenous and oral administration to mature horses .
2666614	0	angiotensin_converting_enzyme	94,123	renin	57,62	angiotensin converting enzyme	renin	610668(Tax:9615)	403838(Tax:9615)	Gene	Gene	inhibition|amod|START_ENTITY lowering|nmod|inhibition lowering|dobj|action action|nmod|inhibition inhibition|compound|END_ENTITY	Characteristics of the blood pressure lowering action of renin inhibition and comparison with angiotensin_converting_enzyme inhibition .
7910063	0	angiotensin_converting_enzyme	27,56	renin	114,119	angiotensin converting enzyme	renin	1636	5972	Gene	Gene	inhibitor|amod|START_ENTITY response|nmod|inhibitor response|dep|relation relation|nmod|status status|compound|END_ENTITY	Blood pressure response to angiotensin_converting_enzyme inhibitor in essential hypertension : its relation to the renin status and natriuresis during acute sodium loading .
8845072	0	angiotensin_converting_enzyme	98,127	renin	34,39	angiotensin converting enzyme	renin	24310(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY Reversal|nmod|inhibition Reversal|nmod|level level|compound|END_ENTITY	Reversal of the suppressed kidney renin level in the hypertensive transgenic rat TGR -LRB- mRen-2 -RRB- 27 by angiotensin_converting_enzyme inhibition .
9231029	0	angiotensin_converting_enzyme	40,69	renin	11,16	angiotensin converting enzyme	renin	610668(Tax:9615)	403838(Tax:9615)	Gene	Gene	compared|xcomp|START_ENTITY compared|nsubj|Effects Effects|nmod|inhibition inhibition|compound|END_ENTITY	Effects of renin inhibition compared to angiotensin_converting_enzyme inhibition in conscious dogs with pacing-induced heart_failure .
15869764	0	angiotensin_ii	42,56	chymase	71,78	angiotensin ii	chymase	24179(Tax:10116)	29265(Tax:10116)	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Angiotensin_converting_enzyme-independent angiotensin_ii production by chymase is up-regulated in the ischemic kidney in renovascular_hypertension .
11230308	0	angiotensin_ii	66,80	renin	47,52	angiotensin ii	renin	183	5972	Gene	Gene	transgene|nmod|START_ENTITY transgene|nsubj|regulation regulation|nmod|END_ENTITY	Paradoxical regulation of short promoter human renin transgene by angiotensin_ii .
12969123	0	angiotensin_type_2	20,38	AT2	40,43	angiotensin type 2	AT2	186	186	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Renal expression of angiotensin_type_2 -LRB- AT2 -RRB- receptors during kidney_damage .
7859090	0	angiotensin_type_2	31,49	AT2	51,54	angiotensin type 2	AT2	24182(Tax:10116)	24182(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Immunohistochemical mapping of angiotensin_type_2 -LRB- AT2 -RRB- receptors in rat brain .
19162259	0	angiotensinogen	37,52	ACE	31,34	angiotensinogen	ACE	183	1636	Gene	Gene	enzyme|appos|START_ENTITY enzyme|appos|END_ENTITY	Angiotensin-converting enzyme -LRB- ACE -RRB- , angiotensinogen -LRB- AGT -RRB- , and angiotensin_II_type_1_receptor -LRB- AT1R -RRB- gene polymorphisms in generalized aggressive periodontitis .
12404103	0	angiotensinogen	33,48	AGT	50,53	angiotensinogen	AGT	183	183	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of putative functional angiotensinogen -LRB- AGT -RRB- gene variants controlling plasma AGT levels by combined segregation-linkage analysis .
15077204	0	angiotensinogen	54,69	AGT	76,79	angiotensinogen	AGT	183	183	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Natural selection and population history in the human angiotensinogen gene -LRB- AGT -RRB- : 736 complete AGT sequences in chromosomes from around the world .
23907112	0	angiotensinogen	56,71	AGT	73,76	angiotensinogen	AGT	183	183	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Simple renal_cysts and hypertension are associated with angiotensinogen -LRB- AGT -RRB- gene variant in Shiraz population -LRB- Iran -RRB- .
7607642	0	angiotensinogen	61,76	AGT	83,86	angiotensinogen	AGT	183	183	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection and characterization of new mutations in the human angiotensinogen gene -LRB- AGT -RRB- .
12805070	0	angiotensinogen	42,57	Angiotensinogen	0,15	angiotensinogen	Angiotensinogen	183	183	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|compound|END_ENTITY	Angiotensinogen gene polymorphism , plasma angiotensinogen , and risk of hypertension and ischemic_heart_disease : a meta-analysis .
16280278	0	angiotensinogen	25,40	G-6A	0,4	angiotensinogen	G-6A	183	23564	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	G-6A polymorphism of the angiotensinogen gene and its association with left_ventricular_mass in asymptomatic young adults from a biethnic community : the Bogalusa Heart Study .
16285960	0	angiotensinogen	115,130	IL-6	97,101	angiotensinogen	IL-6	183	16193(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen .
19583994	0	angiotensinogen	14,29	IL-6	0,4	angiotensinogen	IL-6	183	3569	Gene	Gene	augments|dobj|START_ENTITY augments|nsubj|END_ENTITY	IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells .
9621116	0	angiotensinogen	61,76	IL-6	42,46	angiotensinogen	IL-6	183	3569	Gene	Gene	-RSB-|amod|START_ENTITY regulation|nmod|-RSB- regulation|compound|END_ENTITY	-LSB- Role of CAAT/enhancer _ binding_protein in IL-6 regulation of angiotensinogen gene expression -RSB- .
14617233	0	angiotensinogen	18,33	Insulin	0,7	angiotensinogen	Insulin	183	3630	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Insulin increases angiotensinogen expression in human abdominal subcutaneous adipocytes .
9735335	0	angiotensinogen	23,38	Insulin	0,7	angiotensinogen	Insulin	183	3630	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Insulin down-regulates angiotensinogen gene expression and angiotensinogen secretion in cultured adipose cells .
26607294	0	angiotensinogen	6,21	Renin	0,5	angiotensinogen	Renin	183	5972	Gene	Gene	polymorphisms|compound|START_ENTITY polymorphisms|amod|END_ENTITY	Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent : a systematic review .
6385771	0	angiotensinogen	68,83	Renin	0,5	angiotensinogen	Renin	183	5972	Gene	Gene	analogous|nmod|START_ENTITY substrate|xcomp|analogous substrate|nsubj|cleavage cleavage|compound|END_ENTITY	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
11747312	0	angiotensinogen	65,80	angiotensin_I	27,40	angiotensinogen	angiotensin I	183	183	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release and degradation of angiotensin_I and angiotensin_II from angiotensinogen by neutrophil serine proteinases .
2596583	0	angiotensinogen	14,29	angiotensin_II	44,58	angiotensinogen	angiotensin II	183	183	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Inhibition of angiotensinogen production by angiotensin_II analogues in human hepatoma cell line .
3241235	0	angiotensinogen	14,29	angiotensin_II	44,58	angiotensinogen	angiotensin II	183	183	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Regulation of angiotensinogen production by angiotensin_II analogues .
6696878	1	angiotensinogen	50,65	cathepsin_G	111,122	angiotensinogen	cathepsin G	183	1511	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of angiotensinogen as the plasma protein substrate of leukocyte cathepsin_G .
21306748	0	angiotensinogen	23,38	insulin	49,56	angiotensinogen	insulin	183	3630	Gene	Gene	gene|compound|START_ENTITY gene|nmod|sensitivity sensitivity|compound|END_ENTITY	The association of the angiotensinogen gene with insulin sensitivity in humans : a tagging single nucleotide polymorphism and haplotype approach .
16949687	0	angiotensinogen	22,37	interferon-gamma	66,82	angiotensinogen	interferon-gamma	183	3458	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Upregulation of human angiotensinogen -LRB- AGT -RRB- gene transcription by interferon-gamma : involvement of the STAT1-binding motif in the AGT promoter .
11222745	0	angiotensinogen	105,120	interleukin-6	129,142	angiotensinogen	interleukin-6	183	3569	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Role of signal transducers and activators of transcription 1 and -3 in inducible regulation of the human angiotensinogen gene by interleukin-6 .
26319141	0	angiotensinogen	55,70	miR-31	16,22	angiotensinogen	miR-31	183	407035	Gene	Gene	gene|compound|START_ENTITY site|nmod|gene site|amod|END_ENTITY	Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes .
24812425	0	angiotensinogen	98,113	nuclear_factor_erythroid_2-related_factor_2	33,76	angiotensinogen	nuclear factor erythroid 2-related factor 2	11606(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression stimulation|amod|END_ENTITY	Catalase overexpression prevents nuclear_factor_erythroid_2-related_factor_2 stimulation of renal angiotensinogen gene expression , hypertension , and kidney_injury in diabetic mice .
12037697	0	angiotensinogen	66,81	renin	23,28	angiotensinogen	renin	183	5972	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Heritability of plasma renin activity and plasma concentration of angiotensinogen and angiotensin-converting_enzyme .
15775783	0	angiotensinogen	24,39	renin	90,95	angiotensinogen	renin	183	5972	Gene	Gene	Significance|nmod|START_ENTITY Significance|nmod|function function|nmod|END_ENTITY	Significance of urinary angiotensinogen in essential hypertension as a function of plasma renin and aldosterone status .
1583541	0	angiotensinogen	55,70	renin	78,83	angiotensinogen	renin	183	5972	Gene	Gene	behaviour|nmod|START_ENTITY simulation|nmod|behaviour END_ENTITY|nsubj|simulation	Computer simulation of the conformational behaviour of angiotensinogen -LRB- 6-13 -RRB- renin substrate .
15942685	0	angiotensinogen	54,69	renin	96,101	angiotensinogen	renin	183	5972	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|reaction reaction|nmod|END_ENTITY	Roles of His9 -LRB- P2 subsite -RRB- and His13 -LRB- P3 ' subsite -RRB- in angiotensinogen for catalytic reaction of renin .
16109805	0	angiotensinogen	27,42	renin	71,76	angiotensinogen	renin	11606(Tax:10090)	5972	Gene	Gene	ablation|nmod|START_ENTITY lowers|nsubj|ablation lowers|dobj|pressure pressure|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic_mice .
17261087	0	angiotensinogen	25,40	renin	98,103	angiotensinogen	renin	183	5972	Gene	Gene	motif|nmod|START_ENTITY determinant|nsubj|motif determinant|nmod|specificity specificity|nmod|END_ENTITY	The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin .
1812721	0	angiotensinogen	37,52	renin	148,153	angiotensinogen	renin	183	5972	Gene	Gene	START_ENTITY|nmod|discovery discovery|nmod|inhibitors inhibitors|nmod|END_ENTITY	Exploiting the molecular template of angiotensinogen in the discovery and design of peptidyl , pseudopeptidyl and peptidimimetic inhibitors of human renin : a structure-activity perspective .
1824738	0	angiotensinogen	4,19	renin	123,128	angiotensinogen	renin	183	5972	Gene	Gene	levels|compound|START_ENTITY related|nsubjpass|levels related|nmod|severity severity|dep|implications implications|nmod|measurements measurements|compound|END_ENTITY	Low angiotensinogen levels are related to the severity and liver_dysfunction of congestive_heart_failure : implications for renin measurements .
1856110	0	angiotensinogen	19,34	renin	12,17	angiotensinogen	renin	183	5972	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of renin , angiotensinogen , angiotensin_II in the lamb anterior pituitary gland : immunocytochemical study after cryoultramicrotomy .
19303904	0	angiotensinogen	50,65	renin	88,93	angiotensinogen	renin	183	5972	Gene	Gene	renin|nmod|START_ENTITY cells|nmod|renin exposure|nmod|cells reduces|nsubj|exposure reduces|dobj|END_ENTITY	Prolonged exposure of cardiac cells to renin plus angiotensinogen reduces intracellular renin in the failing heart .
2016704	0	angiotensinogen	198,213	renin	29,34	angiotensinogen	renin	183	5972	Gene	Gene	template|compound|START_ENTITY portion|nmod|template restriction|nmod|portion L-prolyl-L-phenylalanyl-L-histidinamide|nmod|restriction carboxymethyl|dep|L-prolyl-L-phenylalanyl-L-histidinamide peptides|dep|carboxymethyl peptides|compound|END_ENTITY	Conformationally constrained renin inhibitory peptides : cyclic _ -LRB- 3-1 -RRB- -1 - -LRB- carboxymethyl -RRB- - L-prolyl-L-phenylalanyl-L-histidinamide as a conformational restriction at the P2-P4 tripeptide portion of the angiotensinogen template .
2085885	0	angiotensinogen	46,61	renin	19,24	angiotensinogen	renin	183	5972	Gene	Gene	analogs|amod|START_ENTITY containing|nsubj|analogs Synthesis|dep|containing Synthesis|nmod|END_ENTITY	Synthesis of human renin inhibitory peptides , angiotensinogen transition-state analogs containing a retro-inverso_amide bond .
2120440	0	angiotensinogen	50,65	renin	20,25	angiotensinogen	renin	183	5972	Gene	Gene	state|amod|START_ENTITY derived|nmod|state inhibitors|acl|derived inhibitors|compound|END_ENTITY	Orally potent human renin inhibitors derived from angiotensinogen transition state : design , synthesis , and mode of interaction .
22026939	0	angiotensinogen	49,64	renin	14,19	angiotensinogen	renin	183	5972	Gene	Gene	analogues|amod|START_ENTITY activity|nmod|analogues activity|compound|END_ENTITY	Synthesis and renin inhibitory activity of novel angiotensinogen transition state analogues modified at the P -LRB- 2 -RRB- - histidine position .
2407641	0	angiotensinogen	43,58	renin	117,122	angiotensinogen	renin	183	5972	Gene	Gene	gene|compound|START_ENTITY hybridization|nmod|gene Assignment|nmod|hybridization Assignment|dobj|region region|nmod|gene gene|compound|END_ENTITY	Assignment by in situ hybridization of the angiotensinogen gene to chromosome band 1q4 , the same region as the human renin gene .
24154707	0	angiotensinogen	116,131	renin	110,115	angiotensinogen	renin	183	5972	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Renin inhibition ameliorates renal damage through prominent suppression of both angiotensin_I and II in human renin angiotensinogen transgenic_mice with high salt loading .
3275468	0	angiotensinogen	71,86	renin	138,143	angiotensinogen	renin	183	5972	Gene	Gene	site|nmod|START_ENTITY side|nmod|site residues|nmod|side influence|nsubj|residues influence|nmod|END_ENTITY	The amino-acid residues on the C-terminal side of the cleavage site of angiotensinogen influence the species specificity of reaction with renin .
3290486	0	angiotensinogen	43,58	renin	14,19	angiotensinogen	renin	183	5972	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine , Leu psi -LSB- CH2S -RSB- Val , or Leu psi -LSB- CH2SO -RSB- Val at the P1-P1 ' cleavage site .
3314712	0	angiotensinogen	14,29	renin	75,80	angiotensinogen	renin	183	5972	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|substrates substrates|nmod|END_ENTITY	Comparison of angiotensinogen and tetradecapeptide as substrates for human renin .
3514748	0	angiotensinogen	3,18	renin	21,26	angiotensinogen	renin	183	5972	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	Is angiotensinogen a renin inhibitor and not the substrate for renin ?
3912982	0	angiotensinogen	31,46	renin	14,19	angiotensinogen	renin	183	5972	Gene	Gene	Evidence|appos|START_ENTITY Evidence|dep|substrate substrate|compound|END_ENTITY	Evidence that renin substrate -LRB- angiotensinogen -RRB- may be a precursor of erythropoietin .
6159648	0	angiotensinogen	35,50	renin	23,28	angiotensinogen	renin	183	5972	Gene	Gene	analog|compound|START_ENTITY END_ENTITY|nmod|analog	Specific inhibition of renin by an angiotensinogen analog : studies in sodium depletion and renin-dependent hypertension .
6352942	0	angiotensinogen	23,38	renin	14,19	angiotensinogen	renin	183	5972	Gene	Gene	peptide|compound|START_ENTITY END_ENTITY|nmod|peptide	Inhibition of renin by angiotensinogen peptide fragments containing the hydroxy_amino_acid residue 5-amino-3-hydroxy-7-methyloctanoic_acid .
6380499	0	angiotensinogen	26,41	renin	57,62	angiotensinogen	renin	183	5972	Gene	Gene	aspects|nmod|START_ENTITY analogues|nsubj|aspects analogues|nmod|activity activity|amod|END_ENTITY	Conformational aspects of angiotensinogen analogues with renin inhibitory activity .
6385771	0	angiotensinogen	68,83	renin	161,166	angiotensinogen	renin	183	5972	Gene	Gene	START_ENTITY|acl:relcl|specific specific|compound|END_ENTITY	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
6385771	0	angiotensinogen	68,83	renin	33,38	angiotensinogen	renin	183	5972	Gene	Gene	analogous|nmod|START_ENTITY substrate|xcomp|analogous substrate|nsubj|cleavage cleavage|nmod|END_ENTITY	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
6751323	0	angiotensinogen	64,79	renin	14,19	angiotensinogen	renin	183	5972	Gene	Gene	analogues|nmod|START_ENTITY END_ENTITY|nmod|analogues	Inhibition of renin by conformationally restricted analogues of angiotensinogen .
7635534	0	angiotensinogen	71,86	renin	17,22	angiotensinogen	renin	183	5972	Gene	Gene	transgenic|nmod|START_ENTITY Effects|amod|transgenic Effects|nmod|END_ENTITY	Effects of human renin in the vasculature of rats transgenic for human angiotensinogen .
9095095	0	angiotensinogen	57,72	renin	22,27	angiotensinogen	renin	183	5972	Gene	Gene	transgenic|nmod|START_ENTITY effects|amod|transgenic effects|nmod|END_ENTITY	Dose effects of human renin in rats transgenic for human angiotensinogen .
9757569	0	angiotensinogen	64,79	renin	93,98	angiotensinogen	renin	183	5972	Gene	Gene	START_ENTITY|nmod|reaction reaction|compound|END_ENTITY	Effects of glycosylation of the residue at position 14 in ovine angiotensinogen on the human renin reaction .
9931123	0	angiotensinogen	78,93	renin	26,31	angiotensinogen	renin	183	5972	Gene	Gene	pressure|nmod|START_ENTITY pressure|compound|END_ENTITY	Appropriate regulation of renin and blood pressure in 45-kb human renin/human angiotensinogen transgenic_mice .
9972250	0	angiotensinogen	50,65	renin	69,74	angiotensinogen	renin	183	5972	Gene	Gene	Val_for_Leu11|nmod|START_ENTITY Effects|nmod|Val_for_Leu11 Effects|nmod|activity activity|compound|END_ENTITY	Effects of substitution of Val_for_Leu11 of ovine angiotensinogen on renin activity .
20451383	0	anillin	21,28	Cindr	0,5	anillin	Cindr	35696(Tax:7227)	43654(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cindr interacts with anillin to control cytokinesis in Drosophila_melanogaster .
26398495	0	anion_exchanger_1	37,54	peroxiredoxin_6	6,21	anion exchanger 1	peroxiredoxin 6	20533(Tax:10090)	11758(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Renal peroxiredoxin_6 interacts with anion_exchanger_1 and plays a novel role in pH homeostasis .
12592704	0	anion_exchanger_3	49,66	AE3	68,71	anion exchanger 3	AE3	20536(Tax:10090)	20536(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic cloning and promoter analysis of a mouse anion_exchanger_3 -LRB- AE3 -RRB- gene .
19052022	0	anionic_trypsinogen	42,61	PRSS2	63,68	anionic trypsinogen	PRSS2	5645	5645	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A loss-of-function p.G191R variant in the anionic_trypsinogen -LRB- PRSS2 -RRB- gene in Japanese patients with pancreatic_disorders .
26739108	0	ankrd1	13,19	ERK5	0,4	ankrd1	ERK5	27064(Tax:10116)	114509(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells .
14507999	0	ankyrin	14,21	ACD6	0,4	ankyrin	ACD6	835550(Tax:3702)	827085(Tax:3702)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ACD6 , a novel ankyrin protein , is a regulator and an effector of salicylic_acid signaling in the Arabidopsis defense response .
9458832	0	ankyrin	27,34	Ank3	36,40	ankyrin	Ank3	11735(Tax:10090)	11735(Tax:10090)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of epithelial ankyrin -LRB- Ank3 -RRB- spliceoforms in renal proximal and distal tubules .
27054339	0	ankyrin-1	33,42	p53	61,64	ankyrin-1	p53	286	7157	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration .
20936698	0	ankyrin_repeat-rich_membrane_spanning	70,107	kinase_D-interacting_substrate_of_220_kDa	108,149	ankyrin repeat-rich membrane spanning	kinase D-interacting substrate of 220 kDa	57498	57498	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|parataxis|END_ENTITY	Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin_repeat-rich_membrane_spanning / kinase_D-interacting_substrate_of_220_kDa .
16869231	0	ankyrin_repeat_and_kinase_domain_containing_1	47,92	ANKK1	94,99	ankyrin repeat and kinase domain containing 1	ANKK1	255239	255239	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of a structural polymorphism in the ankyrin_repeat_and_kinase_domain_containing_1 -LRB- ANKK1 -RRB- gene and the activation of executive attention networks .
22580979	0	ankyrin_repeat_domain_6	16,39	ANKRD6	46,52	ankyrin repeat domain 6	ANKRD6	22881	22881	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of the ankyrin_repeat_domain_6 gene -LRB- ANKRD6 -RRB- and muscle and physical activity phenotypes among European-derived American adults .
18390587	0	annexin-1	34,43	CD4	79,82	annexin-1	CD4	301	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Glucocorticoid treatment inhibits annexin-1 expression in rheumatoid_arthritis CD4 + T cells .
7802069	0	annexin-V	13,22	placental_anticoagulant_protein-I	24,57	annexin-V	placental anticoagulant protein-I	308	308	Gene	Gene	Reduction|nmod|START_ENTITY Reduction|appos|END_ENTITY	Reduction of annexin-V -LRB- placental_anticoagulant_protein-I -RRB- on placental villi of women with antiphospholipid antibodies and recurrent spontaneous_abortion .
9702415	0	annexin_1	16,25	IL-6	0,4	annexin 1	IL-6	301	3569	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	IL-6 stimulates annexin_1 expression and translocation and suggests a new biological role as class II acute phase protein .
11342653	0	annexin_1	21,30	L-selectin	83,93	annexin 1	L-selectin	301	6402	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|END_ENTITY	A potential role for annexin_1 as a physiologic mediator of glucocorticoid-induced L-selectin shedding from myeloid cells .
16153598	0	annexin_1	23,32	Peroxidase	0,10	annexin 1	Peroxidase	840476(Tax:3702)	816773(Tax:3702)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Peroxidase activity of annexin_1 from Arabidopsis_thaliana .
13679511	0	annexin_2	4,13	S100A10	14,21	annexin 2	S100A10	56611(Tax:10116)	81778(Tax:10116)	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	The annexin_2 / S100A10 complex controls the distribution of transferrin_receptor-containing recycling endosomes .
14699089	0	annexin_2	27,36	S100A10	37,44	annexin 2	S100A10	56611(Tax:10116)	81778(Tax:10116)	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	AHNAK interaction with the annexin_2 / S100A10 complex regulates cell membrane cytoarchitecture .
19724273	0	annexin_2	16,25	S100A6	0,6	annexin 2	S100A6	302	6277	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	S100A6 binds to annexin_2 in pancreatic_cancer cells and promotes pancreatic_cancer cell motility .
11866452	0	annexin_5	42,51	Gonadotropin-releasing_hormone	0,30	annexin 5	Gonadotropin-releasing hormone	25673(Tax:10116)	25194(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Gonadotropin-releasing_hormone stimulates annexin_5 messenger ribonucleic acid expression in the anterior pituitary cells .
12865345	0	annexin_5	19,28	Prolactin	0,9	annexin 5	Prolactin	25673(Tax:10116)	24683(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Prolactin inhibits annexin_5 expression and apoptosis in the corpus luteum of pseudopregnant rats : involvement of local gonadotropin-releasing_hormone .
20079508	0	annexin_9	11,20	ANXA9	27,32	annexin 9	ANXA9	528055(Tax:9913)	528055(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The bovine annexin_9 gene -LRB- ANXA9 -RRB- is significantly associated with milk-fat yield in a Spanish Holstein-Friesian population .
23267026	0	annexin_A1	14,24	CD4	28,31	annexin A1	CD4	16952(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Deficiency of annexin_A1 in CD4 + T cells exacerbates T cell-dependent inflammation .
22123264	0	annexin_A1	45,55	FPR2	56,60	annexin A1	FPR2	301	2358	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Anti-inflammatory drugs , eicosanoids and the annexin_A1 / FPR2 anti-inflammatory system .
23246849	0	annexin_A1	18,28	S100A11	29,36	annexin A1	S100A11	301	6282	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Disruption of the annexin_A1 / S100A11 complex increases the migration and clonogenic growth by dysregulating epithelial_growth_factor -LRB- EGF -RRB- signaling .
22640735	0	annexin_A1	12,22	matrix_metalloproteinase-9	40,66	annexin A1	matrix metalloproteinase-9	301	4318	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of annexin_A1 in expression of matrix_metalloproteinase-9 and invasion of breast_cancer cells .
16285733	0	annexin_A2	57,67	S100A10	68,75	annexin A2	S100A10	302	6281	Gene	Gene	heterotetramer|amod|START_ENTITY heterotetramer|compound|END_ENTITY	Phosphatidylserine membrane domain clustering induced by annexin_A2 / S100A10 heterotetramer .
20085458	0	annexin_A2	89,99	S100A10	14,21	annexin A2	S100A10	302	6281	Gene	Gene	identify|nmod|START_ENTITY used|xcomp|identify used|nsubj|tracer tracer|compound|END_ENTITY	A Cy5-labeled S100A10 tracer used to identify inhibitors of the protein interaction with annexin_A2 .
23091277	0	annexin_A2	26,36	S100A10	53,60	annexin A2	S100A10	302	6281	Gene	Gene	acetylation|nmod|START_ENTITY required|nsubjpass|acetylation required|nmod|binding binding|compound|END_ENTITY	N-terminal acetylation of annexin_A2 is required for S100A10 binding .
23193360	0	annexin_A2	4,14	S100A10	15,22	annexin A2	S100A10	302	6281	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	The annexin_A2 / S100A10 system in health and disease : emerging paradigms .
17575076	0	annexin_A2	53,63	SNAP-23	40,47	annexin A2	SNAP-23	302	8773	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Physical and functional interactions of SNAP-23 with annexin_A2 .
19536308	0	annexin_A2	61,71	Vascular_endothelial_growth_factor	0,34	annexin A2	Vascular endothelial growth factor	12306(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor upregulates expression of annexin_A2 in vitro and in a mouse model of ischemic_retinopathy .
24819400	0	annexin_A2	32,42	matrix_metalloproteinase_13	43,70	annexin A2	matrix metalloproteinase 13	302	4322	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|loop loop|amod|END_ENTITY	The discoidin_domain_receptor_2 / annexin_A2 / matrix_metalloproteinase_13 loop promotes joint_destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes .
19652881	0	annexin_A5	20,30	ANXA5	32,37	annexin A5	ANXA5	308	308	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotype M2 in the annexin_A5 -LRB- ANXA5 -RRB- gene and the occurrence of obstetric complications .
18703851	0	annexin_A5	47,57	Gonadotropin_releasing_hormone	0,30	annexin A5	Gonadotropin releasing hormone	308	2796	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Gonadotropin_releasing_hormone -LRB- GnRH -RRB- enhances annexin_A5 mRNA expression through mitogen activated protein kinase -LRB- MAPK -RRB- in LbetaT2 pituitary gonadotrope cells .
18504344	0	annexin_A5	15,25	gonadotropin_releasing_hormone	40,70	annexin A5	gonadotropin releasing hormone	25673(Tax:10116)	25194(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of annexin_A5 expression by gonadotropin_releasing_hormone -LRB- GnRH -RRB- in the Leydig cells of rats .
25461769	0	annexin_A7	20,30	TIA1	0,4	annexin A7	TIA1	11750(Tax:10090)	21841(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TIA1 interacts with annexin_A7 in regulating vascular endothelial cell autophagy .
8828496	0	annexin_I	51,60	Growth_hormone	0,14	annexin I	Growth hormone	25380(Tax:10116)	81668(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Growth_hormone induces tyrosine phosphorylation of annexin_I in rat_osteosarcoma cells .
7685351	0	annexin_I	66,75	angiotensin_II	20,34	annexin I	angiotensin II	25380(Tax:10116)	24179(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Sustained effect of angiotensin_II on tyrosine phosphorylation of annexin_I in glomerular mesangial cells .
1447309	0	annexin_I	21,30	p35	16,19	annexin I	p35	25380(Tax:10116)	25380(Tax:10116)	Gene	Gene	Localization|dep|START_ENTITY Localization|nmod|END_ENTITY	Localization of p35 -LRB- annexin_I , lipocortin_I -RRB- in normal adult rat kidney and during recovery from ischemia .
14522961	0	annexin_II	65,75	CEACAM1	0,7	annexin II	CEACAM1	302	634	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	CEACAM1 , a cell-cell adhesion molecule , directly associates with annexin_II in a three-dimensional model of mammary morphogenesis .
11978811	0	annexin_II	90,100	Tissue_plasminogen_activator	0,28	annexin II	Tissue plasminogen activator	302	100128998	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Tissue_plasminogen_activator mediates microglial activation via its finger domain through annexin_II .
9545344	0	annexin_II	44,54	Tissue_plasminogen_activator	0,28	annexin II	Tissue plasminogen activator	302	100128998	Gene	Gene	domain|amod|START_ENTITY binding|nmod|domain END_ENTITY|xcomp|binding	Tissue_plasminogen_activator binding to the annexin_II tail domain .
1314068	0	annexin_II	23,33	lipocortin_II	35,48	annexin II	lipocortin II	302	302	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Elevated expression of annexin_II -LRB- lipocortin_II , p36 -RRB- in a multidrug resistant small_cell_lung_cancer cell line .
8634333	0	annexin_II	38,48	p36	33,36	annexin II	p36	12306(Tax:10090)	12306(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Complete structure of the murine p36 -LRB- annexin_II -RRB- gene .
1830024	0	annexin_III	38,49	ANX3	51,55	annexin III	ANX3	306	306	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization of the human annexin_III -LRB- ANX3 -RRB- gene .
8276419	0	annexin_III	41,52	ANX3	54,58	annexin III	ANX3	306	306	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and polymorphisms of the human annexin_III -LRB- ANX3 -RRB- gene .
22223826	0	annexin_II_receptor	33,52	Annexin_II	0,10	annexin II receptor	Annexin II	389289	302	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Annexin_II interactions with the annexin_II_receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment .
1346776	0	annexin_IV	33,43	ANX4	45,49	annexin IV	ANX4	307	307	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal mapping of the human annexin_IV -LRB- ANX4 -RRB- gene .
8034319	0	annexin_V	26,35	ANX5	37,41	annexin V	ANX5	308	308	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Organization of the human annexin_V -LRB- ANX5 -RRB- gene .
16239600	0	annexin_V	18,27	CD31	12,16	annexin V	CD31	308	5175	Gene	Gene	microparticles|amod|START_ENTITY correlate|nsubj|microparticles +|parataxis|correlate +|compound|END_ENTITY	Circulating CD31 + / annexin_V + apoptotic microparticles correlate with coronary endothelial function in patients with coronary_artery_disease .
20520578	0	annexin_V	28,37	CD31	22,26	annexin V	CD31	308	5175	Gene	Gene	+|nsubj|START_ENTITY +|parataxis|+ +|compound|END_ENTITY	Increased circulating CD31 + / annexin_V + apoptotic microparticles and decreased circulating endothelial progenitor cell levels in hypertensive patients with microalbuminuria .
1397263	0	annexin_V	35,44	anchorin_CII	21,33	annexin V	anchorin CII	308	308	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Selective binding of anchorin_CII -LRB- annexin_V -RRB- to type II and X collagen and to chondrocalcin -LRB- C-propeptide of type II collagen -RRB- .
16076491	0	annexin_V	79,88	bcl-2	56,61	annexin V	bcl-2	308	596	Gene	Gene	continue|nmod|START_ENTITY continue|nsubj|cells cells|acl|protected protected|nmod|END_ENTITY	Lymphoma cells protected from apoptosis by dysregulated bcl-2 continue to bind annexin_V in response to B-cell receptor engagement : a cautionary tale .
9099690	0	annexin_V	44,53	phospholipase_A2	24,40	annexin V	phospholipase A2	308	151056	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cytosolic phospholipase_A2 by annexin_V in differentiated permeabilized HL-60 cells .
9425121	0	annexin_V	56,65	phospholipase_A2	30,46	annexin V	phospholipase A2	308	151056	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human cytosolic phospholipase_A2 by human annexin_V .
1386737	0	annexin_V	15,24	prolactin	30,39	annexin V	prolactin	25673(Tax:10116)	24683(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of annexin_V with prolactin in the rat anterior pituitary gland .
1310621	0	annexin_V	34,43	protein_kinase_C	14,30	annexin V	protein kinase C	308	112476	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of protein_kinase_C by annexin_V .
7738119	0	annexin_VII	31,42	synexin	44,51	annexin VII	synexin	310	310	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of annexin_VII -LRB- synexin -RRB- in muscle cells .
8393445	0	annexin_XI	19,29	CAP-50	31,37	annexin XI	CAP-50	311	311	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of annexin_XI -LRB- CAP-50 -RRB- in SR-3Y1 cells .
19696444	0	anosmin-1	99,108	fibroblast_growth_factor_receptor_1	20,55	anosmin-1	fibroblast growth factor receptor 1	3730	2260	Gene	Gene	mechanisms|nmod|START_ENTITY mechanisms|nmod|regulation regulation|amod|END_ENTITY	Novel mechanisms of fibroblast_growth_factor_receptor_1 regulation by extracellular matrix protein anosmin-1 .
18681322	0	anterior_gradient-2	57,76	AGR2	78,82	anterior gradient-2	AGR2	10551	10551	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	-LSB- Expression of a novel metastasis-inducing protein human anterior_gradient-2 -LRB- AGR2 -RRB- in breast_cancer and its clinical and prognostic significance -RSB- .
20945500	0	anterior_gradient_2	4,23	AGR2	25,29	anterior gradient 2	AGR2	10551	10551	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The anterior_gradient_2 -LRB- AGR2 -RRB- gene is overexpressed in prostate_cancer and may be useful as a urine sediment marker for prostate_cancer detection .
23209296	0	anterior_gradient_2	8,27	Agr2	29,33	anterior gradient 2	Agr2	23795(Tax:10090)	23795(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of anterior_gradient_2 -LRB- Agr2 -RRB- expression results in hyperplasia and defective lineage maturation in the murine stomach .
24768923	0	anterior_gradient_2	24,43	Sox10	140,145	anterior gradient 2	Sox10	335616(Tax:7955)	140616(Tax:7955)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of zebrafish anterior_gradient_2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10 .
21451362	0	anterior_gradient_homolog_3	4,31	AGR3	33,37	anterior gradient homolog 3	AGR3	155465	155465	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The anterior_gradient_homolog_3 -LRB- AGR3 -RRB- gene is associated with differentiation and survival in ovarian_cancer .
20048076	0	anterior_gradient_protein_2	60,87	ErbB3_binding_protein_1	0,23	anterior gradient protein 2	ErbB3 binding protein 1	10551	5036	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	ErbB3_binding_protein_1 represses metastasis-promoting gene anterior_gradient_protein_2 in prostate_cancer .
23847299	0	anti-Mullerian_hormone	6,28	AMH	30,33	anti-Mullerian hormone	AMH	268	268	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum anti-Mullerian_hormone -LRB- AMH -RRB- levels correlate with infrarenal aortic diameter in healthy older men : is AMH a cardiovascular hormone ?
6178780	0	anti-invasion_factor	52,72	AIF	74,77	anti-invasion factor	AIF	280989(Tax:9913)	280989(Tax:9913)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural immunohistochemical localization of anti-invasion_factor -LRB- AIF -RRB- in bovine cartilage matrix .
2433811	0	anti-myelin-associated_glycoprotein	58,93	MAG	95,98	anti-myelin-associated glycoprotein	MAG	4099	4099	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Chronic_T_cell_leukemia with a NK phenotype reacting with anti-myelin-associated_glycoprotein -LRB- MAG -RRB- mouse monoclonal antibody .
18570009	0	anti-secretory_factor	11,32	ASF	34,37	anti-secretory factor	ASF	6426	6426	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of anti-secretory_factor -LRB- ASF -RRB- on irritable_bowel_syndrome -LRB- IBS -RRB- .
10456457	0	anticoagulant_protein_C	52,75	protein_C_inhibitor	120,139	anticoagulant protein C	protein C inhibitor	5624	5104	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Lys 62 -LRB- 217 -RRB- and Lys 63 -LRB- 218 -RRB- of human anticoagulant_protein_C in heparin stimulation of inhibition by the protein_C_inhibitor .
167172	0	antidiuretic_hormone	23,43	ADH	45,48	antidiuretic hormone	ADH	551	551	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	The membrane action of antidiuretic_hormone -LRB- ADH -RRB- on toad urinary bladder .
2682381	0	antidiuretic_hormone	12,32	ADH	34,37	antidiuretic hormone	ADH	551	551	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	-LSB- Changes in antidiuretic_hormone -LRB- ADH -RRB- in liver_cirrhosis with resistant ascites -RSB- .
18622203	0	antidiuretic_hormone	28,48	antidiuretic_hormone	74,94	antidiuretic hormone	antidiuretic hormone	551	551	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Differentiating appropriate antidiuretic_hormone secretion , inappropriate antidiuretic_hormone secretion and cerebral salt wasting : the common , uncommon , and misnamed .
18622203	0	antidiuretic_hormone	74,94	antidiuretic_hormone	28,48	antidiuretic hormone	antidiuretic hormone	551	551	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Differentiating appropriate antidiuretic_hormone secretion , inappropriate antidiuretic_hormone secretion and cerebral salt wasting : the common , uncommon , and misnamed .
19851787	0	antidiuretic_hormone	30,50	renin	91,96	antidiuretic hormone	renin	551	5972	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Influence of season on plasma antidiuretic_hormone , angiotensin_II , aldosterone and plasma renin activity in young volunteers .
6368208	0	antidiuretic_hormone	7,27	renin	67,72	antidiuretic hormone	renin	551	5972	Gene	Gene	START_ENTITY|nmod|hypertension hypertension|amod|END_ENTITY	Plasma antidiuretic_hormone levels in patients with normal and low renin essential hypertension , and secondary hypertension .
7935513	0	antithrombin	51,63	AT3	70,73	antithrombin	AT3	462	462	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Trinucleotide repeat polymorphism within the human antithrombin gene -LRB- AT3 -RRB- : allele frequency data for three population groups .
7833476	0	antithrombin	53,65	Fibrinogen	0,10	antithrombin	Fibrinogen	462	2244	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Fibrinogen inhibits the heparin cofactor II-mediated antithrombin activity of dermatan sulfate .
19422445	0	antithrombin	97,109	L-asparaginase	113,127	antithrombin	L-asparaginase	462	80150	Gene	Gene	START_ENTITY|nmod|treatment treatment|amod|END_ENTITY	Dexamethasone induces a heat-stress response that ameliorates the conformational consequences on antithrombin of L-asparaginase treatment .
12627661	0	antithrombin	30,42	Prothrombin	0,11	antithrombin	Prothrombin	462	2147	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	Prothrombin G20210A mutation , antithrombin , heparin cofactor II , protein_C , and protein S defects .
11549250	0	antithrombin	14,26	Syndecan-4	0,10	antithrombin	Syndecan-4	462	6385	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Syndecan-4 as antithrombin receptor of human neutrophils .
16442510	0	antithrombin	23,35	Thrombin	0,8	antithrombin	Thrombin	462	2147	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Thrombin inhibition by antithrombin in the presence of oversulfated dermatan sulfates .
5673827	0	antithrombin	72,84	Thrombin	0,8	antithrombin	Thrombin	462	2147	Gene	Gene	plasma|compound|START_ENTITY filtration|nmod|plasma obtained|nmod|filtration obtained|nsubj|activity activity|compound|END_ENTITY	Thrombin inhibitory activity of fractions obtained by gel filtration of antithrombin 3 deficient plasma .
7272951	0	antithrombin	64,76	Thrombin	0,8	antithrombin	Thrombin	462	2147	Gene	Gene	effect|compound|START_ENTITY inhibition|dep|effect inhibition|compound|END_ENTITY	Thrombin inhibition by malignant and normal cells : a cell-bound antithrombin effect .
3782075	0	antithrombin	129,141	antithrombin	55,67	antithrombin	antithrombin	462	462	Gene	Gene	Role|nmod|START_ENTITY Role|amod|END_ENTITY	Role of ternary complexes , in which heparin binds both antithrombin and proteinase , in the acceleration of the reactions between antithrombin and thrombin or factor_Xa .
3782075	0	antithrombin	55,67	antithrombin	129,141	antithrombin	antithrombin	462	462	Gene	Gene	Role|amod|START_ENTITY Role|nmod|END_ENTITY	Role of ternary complexes , in which heparin binds both antithrombin and proteinase , in the acceleration of the reactions between antithrombin and thrombin or factor_Xa .
5944879	0	antithrombin	43,55	antithrombin	59,71	antithrombin	antithrombin	462	462	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	The influence of calcium on the binding of antithrombin by antithrombin inhibitor .
5944879	0	antithrombin	59,71	antithrombin	43,55	antithrombin	antithrombin	462	462	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	The influence of calcium on the binding of antithrombin by antithrombin inhibitor .
7692967	0	antithrombin	103,115	antithrombin	126,138	antithrombin	antithrombin	462	462	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	High_molecular_weight_kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin : role for antithrombin in the regulation of kallikrein .
7692967	0	antithrombin	126,138	antithrombin	103,115	antithrombin	antithrombin	462	462	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	High_molecular_weight_kininogen potentiates the heparin-accelerated inhibition of plasma kallikrein by antithrombin : role for antithrombin in the regulation of kallikrein .
9616152	0	antithrombin	105,117	antithrombin	30,42	antithrombin	antithrombin	462	462	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Transgenically produced human antithrombin : structural and functional comparison to human plasma-derived antithrombin .
9616152	0	antithrombin	30,42	antithrombin	105,117	antithrombin	antithrombin	462	462	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Transgenically produced human antithrombin : structural and functional comparison to human plasma-derived antithrombin .
10660568	0	antithrombin	50,62	factor_Xa	82,91	antithrombin	factor Xa	462	2159	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|inhibitor inhibitor|nmod|END_ENTITY	Serine 380 -LRB- P14 -RRB- _ -- > _ glutamate mutation activates antithrombin as an inhibitor of factor_Xa .
11278930	1	antithrombin	208,220	factor_Xa	165,174	antithrombin	factor Xa	462	2159	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|determinant determinant|nmod|specificity specificity|compound|END_ENTITY	Evidence for an exosite determinant of factor_Xa specificity in heparin-activated antithrombin .
11380263	0	antithrombin	58,70	factor_Xa	175,184	antithrombin	factor Xa	462	2159	Gene	Gene	loop|nmod|START_ENTITY equilibrium|nmod|loop examined|nsubj|equilibrium examined|nmod|state state|dep|consequences consequences|nmod|mechanism mechanism|nmod|inhibition inhibition|compound|END_ENTITY	Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements : consequences for the mechanism of factor_Xa inhibition by antithrombin-heparin complexes .
11687304	0	antithrombin	83,95	factor_Xa	31,40	antithrombin	factor Xa	462	2159	Gene	Gene	serpin|appos|START_ENTITY mutagenesis|nmod|serpin Probing|nmod|mutagenesis Probing|dobj|basis basis|nmod|specificity specificity|compound|END_ENTITY	Probing the molecular basis of factor_Xa specificity by mutagenesis of the serpin , antithrombin .
12695507	0	antithrombin	83,95	factor_Xa	58,67	antithrombin	factor Xa	462	2159	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|xcomp|responsible responsible|nmod|catalysis catalysis|nmod|inhibition inhibition|nmod|END_ENTITY	Mechanisms responsible for catalysis of the inhibition of factor_Xa or thrombin by antithrombin using a covalent antithrombin-heparin complex .
14575696	0	antithrombin	55,67	factor_Xa	84,93	antithrombin	factor Xa	462	2159	Gene	Gene	inactivation|compound|START_ENTITY inactivation|nmod|END_ENTITY	Platelet_factor_4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor_Xa by preventing interaction -LRB- s -RRB- of enzyme with polysaccharide .
15005625	0	antithrombin	133,145	factor_Xa	85,94	antithrombin	factor Xa	462	2159	Gene	Gene	understanding|nmod|START_ENTITY understanding|dobj|mechanism mechanism|nmod|reactivity reactivity|nmod|END_ENTITY	Mutagenesis studies toward understanding the mechanism of differential reactivity of factor_Xa with the native and heparin-activated antithrombin .
16515805	0	antithrombin	59,71	factor_Xa	35,44	antithrombin	factor Xa	462	2159	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|dependence dependence|nmod|END_ENTITY	Heparin chain-length dependence of factor_Xa inhibition by antithrombin in plasma .
21800826	0	antithrombin	50,62	factor_Xa	93,102	antithrombin	factor Xa	462	2159	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Designing nonsaccharide , allosteric activators of antithrombin for accelerated inhibition of factor_Xa .
24678194	0	antithrombin	78,90	factor_Xa	95,104	antithrombin	factor Xa	462	2159	Gene	Gene	activators|nmod|START_ENTITY specificity|nmod|activators Elucidating|dobj|specificity Elucidating|nmod|inhibition inhibition|compound|END_ENTITY	Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor_Xa inhibition .
9521646	0	antithrombin	29,41	factor_Xa	76,85	antithrombin	factor Xa	462	2159	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	Conformational conversion of antithrombin to a fully activated substrate of factor_Xa without need for heparin .
1112820	0	antithrombin	96,108	factors_V_and_X-a	57,74	antithrombin	factors V and X-a	462	2159	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of human prothrombin by highly purified human factors_V_and_X-a in presence of human antithrombin .
14563633	0	antithrombin	15,27	heparan_sulfate_proteoglycan	79,107	antithrombin	heparan sulfate proteoglycan	462	960	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan_sulfate_proteoglycan , perlecan , in endothelial cells .
14531686	0	antithrombin	150,162	prothrombin	180,191	antithrombin	prothrombin	462	2147	Gene	Gene	peptide|compound|START_ENTITY peptide|nmod|END_ENTITY	Probing the kinetic landscape of transient peptide-protein interactions by use of peptide -LRB- 15 -RRB- n NMR relaxation dispersion spectroscopy : binding of an antithrombin peptide to human prothrombin .
10037709	0	antithrombin	108,120	thrombin	62,70	antithrombin	thrombin	462	2147	Gene	Gene	essential|nmod|START_ENTITY essential|nmod|protection protection|nmod|END_ENTITY	Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II .
10064273	0	antithrombin	11,23	thrombin	41,49	antithrombin	thrombin	462	2147	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|generation generation|compound|END_ENTITY	Effects of antithrombin and protein_C on thrombin generation in newborn and adult plasma .
10691099	0	antithrombin	94,106	thrombin	28,36	antithrombin	thrombin	462	2147	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|modulation modulation|nmod|generation generation|compound|END_ENTITY	Pharmacologic modulation of thrombin generation associated with human clots by human purified antithrombin alone or in the presence of low molecular weight heparin or unfractionated heparin .
10784436	0	antithrombin	57,69	thrombin	16,24	antithrombin	thrombin	462	2147	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activity activity|amod|END_ENTITY	Most clot-bound thrombin activity is inhibited by plasma antithrombin during clot aging , but a very small fraction survives .
11278930	0	antithrombin	36,48	thrombin	53,61	antithrombin	thrombin	462	2147	Gene	Gene	START_ENTITY|nmod|independent independent|compound|END_ENTITY	Heparin enhances the specificity of antithrombin for thrombin and factor_Xa independent of the reactive center loop sequence .
11739542	0	antithrombin	128,140	thrombin	116,124	antithrombin	thrombin	462	2147	Gene	Gene	interfere|nmod|START_ENTITY interfere|nmod|inactivation inactivation|nmod|END_ENTITY	Identification of anti-thrombin antibodies in the antiphospholipid_syndrome that interfere with the inactivation of thrombin by antithrombin .
12871499	0	antithrombin	61,73	thrombin	92,100	antithrombin	thrombin	462	2147	Gene	Gene	together|nmod|START_ENTITY allows|advmod|together allows|dobj|generation generation|compound|END_ENTITY	Low tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- together with low antithrombin allows sufficient thrombin generation in neonates .
16078853	0	antithrombin	48,60	thrombin	75,83	antithrombin	thrombin	462	2147	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Mechanism of poly -LRB- acrylic_acid -RRB- acceleration of antithrombin inhibition of thrombin : implications for the design of novel heparin mimics .
16413239	0	antithrombin	18,30	thrombin	40,48	antithrombin	thrombin	462	2147	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|iobj|formation formation|amod|END_ENTITY	Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia .
16856890	0	antithrombin	120,132	thrombin	51,59	antithrombin	thrombin	462	2147	Gene	Gene	deficiency|compound|START_ENTITY Comparison|nmod|deficiency Comparison|nmod|inhibitor inhibitor|compound|END_ENTITY	Comparison of the anticoagulant effect of a direct thrombin inhibitor and a low molecular weight heparin in an acquired antithrombin deficiency in children with acute_lymphoblastic_leukaemia treated with L-asparaginase : an in vitro study .
17689549	0	antithrombin	83,95	thrombin	71,79	antithrombin	thrombin	462	2147	Gene	Gene	DNA|compound|START_ENTITY END_ENTITY|nmod|DNA	Surface plasmon resonance spectroscopy study of interfacial binding of thrombin to antithrombin DNA aptamers .
18180618	0	antithrombin	18,30	thrombin	201,209	antithrombin	thrombin	462	2147	Gene	Gene	antibody|compound|START_ENTITY existence|nmod|antibody existence|dep|directing directing|nmod|II II|nmod|END_ENTITY	Sole existence of antithrombin antibody in patients with systemic_lupus_erythematosus showing tendency of its antigenic determinants directing against exosite II -LRB- antithrombin/heparin binding site -RRB- of thrombin .
22978548	0	antithrombin	167,179	thrombin	139,147	antithrombin	thrombin	462	2147	Gene	Gene	protects|nmod|START_ENTITY protects|dobj|END_ENTITY	By increasing the affinity of heparin for fibrin , Zn -LRB- 2 + -RRB- promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin .
25402190	0	antithrombin	102,114	thrombin	52,60	antithrombin	thrombin	462	2147	Gene	Gene	levels|compound|START_ENTITY correlated|nmod|levels increase|acl:relcl|correlated increase|nmod|generation generation|compound|END_ENTITY	Patients with cirrhosis show a relative increase in thrombin generation that is correlated with lower antithrombin levels .
3584126	1	antithrombin	149,161	thrombin	81,89	antithrombin	thrombin	462	2147	Gene	Gene	region|nmod|START_ENTITY induce|nmod|region induce|dep|cleavage cleavage|nmod|END_ENTITY	I. Does cleavage by thrombin induce structural changes in the heparin-binding region of antithrombin ?
3584127	2	antithrombin	113,125	thrombin	161,169	antithrombin	thrombin	462	2147	Gene	Gene	START_ENTITY|acl|required required|nmod|inactivation inactivation|nmod|END_ENTITY	Is the heparin-induced conformational change in antithrombin required for rapid inactivation of thrombin ?
3955055	0	antithrombin	83,95	thrombin	71,79	antithrombin	thrombin	462	2147	Gene	Gene	regulate|nmod|START_ENTITY regulate|dobj|inhibition inhibition|nmod|END_ENTITY	Thrombin-reactive polypeptides of platelets may regulate inhibition of thrombin by antithrombin .
4052633	0	antithrombin	42,54	thrombin	30,38	antithrombin	thrombin	462	2147	Gene	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|END_ENTITY	The kinetics of inhibition of thrombin by antithrombin in the presence of components of the hemostatic system .
5932766	0	antithrombin	56,68	thrombin	20,28	antithrombin	thrombin	462	2147	Gene	Gene	due|nmod|START_ENTITY time|amod|due time|compound|END_ENTITY	-LSB- Lengthening of the thrombin time due to an anti-equine antithrombin in a case of hyperthrombocytic myelosis -RSB- .
6688430	1	antithrombin	143,155	thrombin	120,128	antithrombin	thrombin	462	2147	Gene	Gene	charge|nmod|START_ENTITY charge|dobj|domains domains|nmod|inhibition inhibition|compound|END_ENTITY	Independence of heparin charge density and antithrombin-binding domains in thrombin inhibition by antithrombin and heparin_cofactor_II .
7364749	0	antithrombin	20,32	thrombin	69,77	antithrombin	thrombin	462	2147	Gene	Gene	bond|nmod|START_ENTITY required|nsubjpass|bond required|nmod|inactivation inactivation|compound|END_ENTITY	A disulfide bond in antithrombin is required for heparin-accelerated thrombin inactivation .
7974394	0	antithrombin	21,33	thrombin	51,59	antithrombin	thrombin	462	2147	Gene	Gene	concentration|compound|START_ENTITY concentration|nmod|generation generation|compound|END_ENTITY	The effect of plasma antithrombin concentration on thrombin generation and fibrin gel structure .
8136018	0	antithrombin	29,41	thrombin	15,23	antithrombin	thrombin	462	2147	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin with antithrombin , heparin_cofactor_II , and protein_C_inhibitor .
8288594	0	antithrombin	104,116	thrombin	47,55	antithrombin	thrombin	462	2147	Gene	Gene	III|compound|START_ENTITY essential|nmod|III essential|nsubj|Identification Identification|nmod|residues residues|nmod|END_ENTITY	Identification of basic amino_acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III .
8987163	0	antithrombin	75,87	thrombin	14,22	antithrombin	thrombin	462	2147	Gene	Gene	fused|nmod|START_ENTITY Inhibition|amod|fused Inhibition|nmod|END_ENTITY	Inhibition of thrombin by hirudin genetically fused to wild-type or mutant antithrombin .
9031720	0	antithrombin	36,48	thrombin	13,21	antithrombin	thrombin	462	2147	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of thrombin inhibition by antithrombin and heparin_cofactor_II in the presence of heparin .
9214615	0	antithrombin	111,123	thrombin	4,12	antithrombin	thrombin	462	2147	Gene	Gene	interaction|nmod|START_ENTITY implications|nmod|interaction rearrangements|dep|implications reveals|dobj|rearrangements reveals|nsubj|complex complex|compound|END_ENTITY	The thrombin E192Q-BPTI complex reveals gross structural rearrangements : implications for the interaction with antithrombin and thrombomodulin .
9361370	0	antithrombin	66,78	thrombin	84,92	antithrombin	thrombin	462	2147	Gene	Gene	reaction|nmod|START_ENTITY positions|nmod|reaction positions|nmod|END_ENTITY	Impact of mutations at the P4_and_P5 positions on the reaction of antithrombin with thrombin and elastase .
8473344	0	antithrombin-III	82,98	thrombin	34,42	antithrombin-III	thrombin	462	2147	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of heparin-dependent thrombin and factor_Xa inhibitory activities of antithrombin-III by mutations in the reactive site .
1505975	0	antithrombin_III	36,52	AT3	54,57	antithrombin III	AT3	462	462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	De novo splice site mutation in the antithrombin_III -LRB- AT3 -RRB- gene causing recurrent venous_thrombosis : demonstration of exon skipping by ectopic transcript analysis .
7959685	0	antithrombin_III	38,54	AT3	56,59	antithrombin III	AT3	462	462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Three novel missense mutations in the antithrombin_III -LRB- AT3 -RRB- gene causing recurrent venous_thrombosis .
2465218	0	antithrombin_III	11,27	AT_III	29,35	antithrombin III	AT III	462	462	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes of antithrombin_III -LRB- AT_III -RRB- in AT_III_deficient patients during long-term anticoagulant treatment .
17940748	0	antithrombin_III	10,26	HMGB1	36,41	antithrombin III	HMGB1	304917(Tax:10116)	25459(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	High dose antithrombin_III inhibits HMGB1 and improves endotoxin-induced acute_lung_injury in rats .
3754869	1	antithrombin_III	135,151	S-protein	120,129	antithrombin III	S-protein	462	7448	Gene	Gene	inactivation|amod|START_ENTITY Protection|nmod|inactivation Protection|nmod|END_ENTITY	Protection of thrombin by S-protein from antithrombin_III inactivation .
11728442	0	antithrombin_III	30,46	TLR-4	93,98	antithrombin III	TLR-4	462	7099	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The serine_protease inhibitor antithrombin_III inhibits LPS-mediated NF-kappaB activation by TLR-4 .
9409233	0	antithrombin_III	99,115	Thrombin	0,8	antithrombin III	Thrombin	304917(Tax:10116)	29251(Tax:10116)	Gene	Gene	binds|dobj|START_ENTITY activity|acl:relcl|binds stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Thrombin stimulates syndecan-1 promotor activity and expression of a form of syndecan-1 that binds antithrombin_III in vascular smooth muscle cells .
15792522	0	antithrombin_III	11,27	myeloperoxidase	31,46	antithrombin III	myeloperoxidase	304917(Tax:10116)	303413(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effects of antithrombin_III on myeloperoxidase activity , superoxide dismutase activity , and malondialdehyde levels and histopathological findings after spinal_cord_injury in the rat .
2752479	0	antithrombin_III	22,38	protein_C	50,59	antithrombin III	protein C	462	5624	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Synergistic effect of antithrombin_III , activated protein_C and heparin on the inhibition of the tissue thromboplastin-mediated coagulation .
11051806	0	antithrombin_III	38,54	thrombin	78,86	antithrombin III	thrombin	462	2147	Gene	Gene	activities|amod|START_ENTITY heparin_cofactor_II|nmod|activities Effect|nmod|heparin_cofactor_II measured|nsubj|Effect measured|nmod|methods methods|compound|END_ENTITY	-LSB- Effect of heparin_cofactor_II on the antithrombin_III activities measured by thrombin methods or factor_Xa methods -- fundamental studies and clinical studies using the plasma of pregnant women -RSB- .
2020936	0	antithrombin_III	11,27	thrombin	70,78	antithrombin III	thrombin	100125972(Tax:9823)	100144442(Tax:9823)	Gene	Gene	START_ENTITY|dep|complex complex|nmod|inhibitor inhibitor|nmod|END_ENTITY	A purified antithrombin_III -- heparin complex as a potent inhibitor of thrombin in porcine endotoxin shock .
2081384	0	antithrombin_III	100,116	thrombin	19,27	antithrombin III	thrombin	462	2147	Gene	Gene	Sensitivity|nmod|START_ENTITY Sensitivity|nmod|time time|compound|END_ENTITY	Sensitivity of the thrombin clotting time and activated partial thromboplastin time to low level of antithrombin_III during heparin therapy .
2154059	0	antithrombin_III	76,92	thrombin	58,66	antithrombin III	thrombin	462	2147	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|inactivation inactivation|nmod|END_ENTITY	The effect of human thrombomodulin on the inactivation of thrombin by human antithrombin_III .
2476159	0	antithrombin_III	139,155	thrombin	80,88	antithrombin III	thrombin	462	2147	Gene	Gene	sulfate|nmod|START_ENTITY sulfate|nmod|inactivation inactivation|nmod|END_ENTITY	The molecular-mass dependence of dextran sulfate enhancement of inactivation of thrombin and fibrinogen and on factor_Xa neutralization by antithrombin_III .
2910581	0	antithrombin_III	123,139	thrombin	94,102	antithrombin III	thrombin	462	2147	Gene	Gene	assay|nmod|START_ENTITY assay|compound|END_ENTITY	Increased concentrations of heparin cofactor II in diabetic patients , and possible effects on thrombin inhibition assay of antithrombin_III .
2973155	0	antithrombin_III	30,46	thrombin	18,26	antithrombin III	thrombin	462	2147	Gene	Gene	Neutralization|nmod|START_ENTITY Neutralization|nmod|END_ENTITY	Neutralization of thrombin by antithrombin_III in the presence of cultured human fibroblasts .
3754869	1	antithrombin_III	135,151	thrombin	108,116	antithrombin III	thrombin	462	2147	Gene	Gene	inactivation|amod|START_ENTITY Protection|nmod|inactivation Protection|nmod|END_ENTITY	Protection of thrombin by S-protein from antithrombin_III inactivation .
3790599	0	antithrombin_III	89,105	thrombin	106,114	antithrombin III	thrombin	540261(Tax:9913)	280685(Tax:9913)	Gene	Gene	proteins|nmod|START_ENTITY behavior|nmod|proteins Comparison|nmod|behavior /|nsubj|Comparison /|dobj|reaction reaction|compound|END_ENTITY	Comparison of the kinetic behavior of human and bovine proteins in the heparin-catalyzed antithrombin_III / thrombin reaction .
6166063	0	antithrombin_III	20,36	thrombin	66,74	antithrombin III	thrombin	462	2147	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|inactivation inactivation|compound|END_ENTITY	Respective roles of antithrombin_III and alpha_2_macroglobulin in thrombin inactivation .
6209818	0	antithrombin_III	56,72	thrombin	73,81	antithrombin III	thrombin	462	2147	Gene	Gene	sulfate|nmod|START_ENTITY Abolition|nmod|sulfate reaction|nmod|Abolition reaction|compound|END_ENTITY	Abolition by dextran sulfate of the heparin-accelerated antithrombin_III / thrombin reaction .
6719385	0	antithrombin_III	51,67	thrombin	31,39	antithrombin III	thrombin	462	2147	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of immobilized thrombin with human antithrombin_III .
7540283	0	antithrombin_III	46,62	thrombin	67,75	antithrombin III	thrombin	462	2147	Gene	Gene	START_ENTITY|nmod|regulation regulation|compound|END_ENTITY	alpha_2-Macroglobulin remains as important as antithrombin_III for thrombin regulation in cord plasma in the presence of endothelial cell surfaces .
8259541	0	antithrombin_III	70,86	thrombin	124,132	antithrombin III	thrombin	462	2147	Gene	Gene	START_ENTITY|dep|associates associates|nmod|END_ENTITY	Recombinant human soluble thrombomodulin delivers bounded thrombin to antithrombin_III : thrombomodulin associates with free thrombin and is recycled to activate protein_c .
8259541	0	antithrombin_III	70,86	thrombin	58,66	antithrombin III	thrombin	462	2147	Gene	Gene	delivers|nmod|START_ENTITY delivers|dobj|END_ENTITY	Recombinant human soluble thrombomodulin delivers bounded thrombin to antithrombin_III : thrombomodulin associates with free thrombin and is recycled to activate protein_c .
8286739	0	antithrombin_III	147,163	thrombin	21,29	antithrombin III	thrombin	462	2147	Gene	Gene	deficiency|compound|START_ENTITY thrombotic_complications|nmod|deficiency risk|nmod|thrombotic_complications generation|dep|risk generation|compound|END_ENTITY	Increased endogenous thrombin generation in children with acute_lymphoblastic_leukemia : risk of thrombotic_complications in L'Asparaginase-induced antithrombin_III deficiency .
8470046	0	antithrombin_III	109,125	thrombin	160,168	antithrombin III	thrombin	462	2147	Gene	Gene	deficiency|compound|START_ENTITY identify|dobj|deficiency identify|nmod|assay assay|acl|based based|nmod|inhibition inhibition|compound|END_ENTITY	An antithrombin_III assay based on factor_Xa inhibition provides a more reliable test to identify congenital antithrombin_III deficiency than an assay based on thrombin inhibition .
8470046	0	antithrombin_III	3,19	thrombin	160,168	antithrombin III	thrombin	462	2147	Gene	Gene	assay|amod|START_ENTITY provides|nsubj|assay provides|advcl|identify identify|nmod|assay assay|acl|based based|nmod|inhibition inhibition|compound|END_ENTITY	An antithrombin_III assay based on factor_Xa inhibition provides a more reliable test to identify congenital antithrombin_III deficiency than an assay based on thrombin inhibition .
8470059	0	antithrombin_III	12,28	thrombin	103,111	antithrombin III	thrombin	462	2147	Gene	Gene	levels|compound|START_ENTITY ineffective|nsubj|levels ineffective|advcl|quenching quenching|dobj|generation generation|compound|END_ENTITY	Supranormal antithrombin_III levels induced by concentrate administration are ineffective in quenching thrombin generation in acute_promyelocytic_leukemia .
2154059	0	antithrombin_III	76,92	thrombomodulin	20,34	antithrombin III	thrombomodulin	462	7056	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of human thrombomodulin on the inactivation of thrombin by human antithrombin_III .
8052962	0	antithrombin_III	150,166	thrombomodulin	37,51	antithrombin III	thrombomodulin	304917(Tax:10116)	7056	Gene	Gene	levels|nmod|START_ENTITY Effects|nmod|levels Effects|nmod|END_ENTITY	Effects of recombinant human soluble thrombomodulin -LRB- rhs-TM -RRB- on a rat model of disseminated_intravascular_coagulation with decreased levels of plasma antithrombin_III .
11798464	0	antithrombin_III	11,27	tumor_necrosis_factor-alpha	31,58	antithrombin III	tumor necrosis factor-alpha	462	7124	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Effects of antithrombin_III on tumor_necrosis_factor-alpha and interleukin-1beta synthesis in vascular smooth muscle cells .
15385572	0	antizyme-1	82,92	ornithine_decarboxylase	30,53	antizyme-1	ornithine decarboxylase	4946	4953	Gene	Gene	START_ENTITY|dep|localization localization|nmod|END_ENTITY	Intracellular localization of ornithine_decarboxylase and its regulatory protein , antizyme-1 .
19756694	0	antizyme_inhibitor_2	19,39	ornithine_decarboxylase	57,80	antizyme inhibitor 2	ornithine decarboxylase	113451	4953	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	High expression of antizyme_inhibitor_2 , an activator of ornithine_decarboxylase in steroidogenic cells of human gonads .
10617103	0	apelin	20,26	APJ	47,50	apelin	APJ	58812(Tax:10116)	83518(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|ligand ligand|nmod|receptor receptor|compound|END_ENTITY	Characterization of apelin , the ligand for the APJ receptor .
12494874	0	apelin	29,35	APJ	68,71	apelin	APJ	8862	187	Gene	Gene	study|nmod|START_ENTITY study|appos|ligand ligand|nmod|END_ENTITY	Immunohistochemical study of apelin , the natural ligand of receptor APJ , in a case of AIDS-related cachexia .
12914775	0	apelin	34,40	APJ	82,85	apelin	APJ	8862	187	Gene	Gene	levels|nmod|START_ENTITY levels|appos|novel novel|acl|ligand ligand|nmod|END_ENTITY	Circulating and cardiac levels of apelin , the novel ligand of the orphan receptor APJ , in patients with heart_failure .
15664671	0	apelin	39,45	APJ	56,59	apelin	APJ	58812(Tax:10116)	187	Gene	Gene	receptor|compound|START_ENTITY localisation|nmod|receptor localisation|appos|END_ENTITY	Immunocytochemical localisation of the apelin receptor , APJ , to human cardiomyocytes , vascular smooth muscle and endothelial cells .
25150624	0	apelin	77,83	APJ	101,104	apelin	APJ	8862	187	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation evidences|nmod|role END_ENTITY|nsubj|evidences	Molecular and physiological evidences for the role in appetite regulation of apelin and its receptor APJ in Ya-fish -LRB- Schizothorax prenanti -RRB- .
17826642	0	apelin	70,76	APJ_receptor	24,36	apelin	APJ receptor	8862	187	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The 212A variant of the APJ_receptor gene for the endogenous inotrope apelin is associated with slower heart_failure progression in idiopathic_dilated_cardiomyopathy .
22895257	0	apelin	14,20	BMP	35,38	apelin	BMP	8862	649	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of apelin expression by BMP signaling in endothelial cells .
18501443	0	apelin	57,63	PGC-1alpha	33,43	apelin	PGC-1alpha	8862	10891	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes .
20208458	0	apelin	41,47	adiponectin	28,39	apelin	adiponectin	8862	9370	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Relationships between serum adiponectin , apelin , leptin , resistin , visfatin levels and bone_mineral_density , and bone biochemical markers in post-menopausal Chinese women .
20208458	0	apelin	41,47	visfatin	67,75	apelin	visfatin	8862	10135	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	Relationships between serum adiponectin , apelin , leptin , resistin , visfatin levels and bone_mineral_density , and bone biochemical markers in post-menopausal Chinese women .
21669562	0	apelin	28,34	visfatin	36,44	apelin	visfatin	8862	10135	Gene	Gene	adiponectin|compound|START_ENTITY adiponectin|dep|END_ENTITY	New adipocytokines -LRB- vaspin , apelin , visfatin , adiponectin -RRB- levels in children treated with valproic_acid .
25437815	0	apg-2	37,42	heat_shock_protein_a4	15,36	apg-2	heat shock protein a4	3308	3308	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of heat_shock_protein_a4 / apg-2 in refractory inflammatory_bowel_disease .
16150853	0	apical_sodium_dependent_bile_acid_transporter	33,78	ASBT	80,84	apical sodium dependent bile acid transporter	ASBT	6555	6555	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Adaptive regulation of the ileal apical_sodium_dependent_bile_acid_transporter -LRB- ASBT -RRB- in patients with obstructive cholestasis .
11126402	0	apoA-I	31,37	apoA-II	40,47	apoA-I	apoA-II	335	336	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Differences in HDL-cholesterol : apoA-I + apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients .
11290828	0	apoA-I	33,39	apoA-II	24,31	apoA-I	apoA-II	11806(Tax:10090)	11807(Tax:10090)	Gene	Gene	START_ENTITY|nmod|interactions interactions|nmod|END_ENTITY	In vivo interactions of apoA-II , apoA-I , and hepatic_lipase contributing to HDL structure and antiatherogenic functions .
7918309	0	apoA-I	45,51	apoA-II	60,67	apoA-I	apoA-II	335	336	Gene	Gene	containing|dobj|START_ENTITY containing|nmod|END_ENTITY	Distribution of subclasses of HDL containing apoA-I without apoA-II -LRB- LpA-I -RRB- in normolipidemic men and women .
11126402	0	apoA-II	40,47	apoA-I	31,37	apoA-II	apoA-I	336	335	Gene	Gene	ratio|compound|START_ENTITY ratio|compound|END_ENTITY	Differences in HDL-cholesterol : apoA-I + apoA-II ratio and apoE phenotype with albuminuric status in Type I diabetic patients .
11290828	0	apoA-II	24,31	apoA-I	33,39	apoA-II	apoA-I	11807(Tax:10090)	11806(Tax:10090)	Gene	Gene	interactions|nmod|START_ENTITY END_ENTITY|nmod|interactions	In vivo interactions of apoA-II , apoA-I , and hepatic_lipase contributing to HDL structure and antiatherogenic functions .
7918309	0	apoA-II	60,67	apoA-I	45,51	apoA-II	apoA-I	336	335	Gene	Gene	containing|nmod|START_ENTITY containing|dobj|END_ENTITY	Distribution of subclasses of HDL containing apoA-I without apoA-II -LRB- LpA-I -RRB- in normolipidemic men and women .
9565615	0	apoB	93,97	Sec61	105,110	apoB	Sec61	338	29927	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex .
1597147	0	apoB	47,51	apolipoprotein-B	29,45	apoB	apolipoprotein-B	54225(Tax:10116)	54225(Tax:10116)	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Effects of growth_hormone on apolipoprotein-B -LRB- apoB -RRB- messenger ribonucleic acid editing , and apoB_48 and apoB_100 synthesis and secretion in the rat liver .
10705993	0	apoB	111,115	apolipoprotein_B	18,34	apoB	apolipoprotein B	238055(Tax:10090)	238055(Tax:10090)	Gene	Gene	Regulation|amod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the apolipoprotein_B in heterozygous_hypobetalipoproteinemic knock-out mice expressing truncated apoB , B81 .
2450346	0	apoB	24,28	apolipoprotein_B	6,22	apoB	apolipoprotein B	338	338	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Human apolipoprotein_B -LRB- apoB -RRB- mRNA : identification of two distinct apoB mRNAs , an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon , in both liver and intestine .
20890106	0	apoB	0,4	p53	88,91	apoB	p53	238055(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	apoB and apobec1 , two genes key to lipid metabolism , are transcriptionally regulated by p53 .
20030174	0	apoB-48	47,54	apolipoprotein_B-48	26,45	apoB-48	apolipoprotein B-48	338	338	Gene	Gene	significance|dep|START_ENTITY significance|nmod|END_ENTITY	-LSB- Clinical significance of apolipoprotein_B-48 -LRB- apoB-48 -RRB- in patients with thyroid_disease -RSB- .
9350999	0	apoC-III	14,22	TNFalpha	42,50	apoC-III	TNFalpha	345	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Repression of apoC-III gene expression by TNFalpha involves C/EBPdelta/NF-IL 6beta via an IL-1 independent pathway .
12676346	0	apoE	18,22	Apolipoprotein_E	0,16	apoE	Apolipoprotein E	348	348	Gene	Gene	dependent|dep|START_ENTITY dependent|advmod|END_ENTITY	Apolipoprotein_E -LRB- apoE -RRB- uptake and distribution in mammalian cell lines is dependent upon source of apoE and can be monitored in living cells .
19733021	0	apoE	18,22	Apolipoprotein_E	0,16	apoE	Apolipoprotein E	348	348	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Apolipoprotein_E -LRB- apoE -RRB- polymorphism : a risk factor for fatal coronary_sclerosis ?
7814023	0	apoE	18,22	Apolipoprotein_E	0,16	apoE	Apolipoprotein E	348	348	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Apolipoprotein_E -LRB- apoE -RRB- polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer 's _ disease .
8813351	0	apoE	18,22	Apolipoprotein_E	0,16	apoE	Apolipoprotein E	348	348	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Apolipoprotein_E -LRB- apoE -RRB- levels in brains from Alzheimer_disease patients and controls .
12454263	0	apoE	49,53	FXR	60,63	apoE	FXR	348	9971	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors .
20005558	0	apoE	89,93	LDLR	97,101	apoE	LDLR	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|parataxis|END_ENTITY	The effect of the long term aspirin administration on the progress of atherosclerosis in apoE - / - LDLR - / - double knockout mouse .
10357834	0	apoE	37,41	LDL_receptor	0,12	apoE	LDL receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	LDL_receptor binds newly synthesized apoE in macrophages .
12475897	0	apoE	108,112	LDL_receptor	95,107	apoE	LDL receptor	348	3949	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Pharmacological interference with intestinal bile_acid transport reduces plasma cholesterol in LDL_receptor / apoE deficiency .
26731985	0	apoE	71,75	NOX4	63,67	apoE	NOX4	11816(Tax:10090)	50490(Tax:10090)	Gene	Gene	Mice|amod|START_ENTITY END_ENTITY|nmod|Mice	miR-31 Overexpression Exacerbates Atherosclerosis by Targeting NOX4 in apoE -LRB- - / - -RRB- Mice .
15863833	0	apoE	4,8	VLDL_receptor	43,56	apoE	VLDL receptor	348	7436	Gene	Gene	properties|amod|START_ENTITY properties|nmod|END_ENTITY	The apoE isoform binding properties of the VLDL_receptor reveal marked differences from LRP and the LDL_receptor .
21763672	0	apoE	40,44	angiotensin_II	22,36	apoE	angiotensin II	11816(Tax:10090)	11606(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Prolonged infusion of angiotensin_II in apoE -LRB- - / - -RRB- mice promotes macrophage recruitment with continued expansion of abdominal_aortic_aneurysm .
14505229	0	apoE	124,128	apolipoprotein_E	106,122	apoE	apolipoprotein E	348	348	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Log-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein_E -LRB- apoE -RRB- gene in Alzheimer 's _ disease .
15936307	0	apoE	28,32	apolipoprotein_E	10,26	apoE	apolipoprotein E	348	348	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of apolipoprotein_E -LRB- apoE -RRB- phenotype on the apoE content of CSF-HDL in children .
9058415	0	apoE	35,39	apolipoprotein_E	17,33	apoE	apolipoprotein E	348	348	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Increased plasma apolipoprotein_E -LRB- apoE -RRB- levels in Alzheimer 's _ disease .
9223597	0	apoE	38,42	apolipoprotein_E	20,36	apoE	apolipoprotein E	348	348	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Cerebrospinal fluid apolipoprotein_E -LRB- apoE -RRB- levels in Alzheimer 's _ disease patients are increased at follow up and show a correlation with levels of tau protein .
25586482	0	apoM	111,115	Monocyte_Chemoattractant_Protein-1	47,81	apoM	Monocyte Chemoattractant Protein-1	55937	6347	Gene	Gene	Production|dep|START_ENTITY Production|compound|END_ENTITY	Propofol Attenuates Lipopolysaccharide-Induced Monocyte_Chemoattractant_Protein-1 Production Through Enhancing apoM and foxa2 Expression in HepG2 Cells .
11040400	0	apo_A	60,65	apo_B	54,59	apo A	apo B	4018	338	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	An hydroalcoholic extract of curcuma longa lowers the apo_B / apo_A ratio .
11040400	0	apo_B	54,59	apo_A	60,65	apo B	apo A	338	4018	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	An hydroalcoholic extract of curcuma longa lowers the apo_B / apo_A ratio .
18068040	0	apobec-1	116,124	low-density_lipoprotein_receptor	130,162	apobec-1	low-density lipoprotein receptor	11810(Tax:10090)	16835(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1 -LRB- - / - -RRB- / low-density_lipoprotein_receptor -LRB- - / - -RRB- mice .
11584023	0	apobec-1-binding_protein-2	16,42	DnaJ	2,6	apobec-1-binding protein-2	DnaJ	51726	10294	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	A DnaJ protein , apobec-1-binding_protein-2 , modulates apolipoprotein B mRNA editing .
11718896	0	apobec-1_complementation_factor	70,101	ACF	103,106	apobec-1 complementation factor	ACF	29974	29974	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation , characterization and developmental regulation of the human apobec-1_complementation_factor -LRB- ACF -RRB- gene .
18701171	0	apolipoprotein-B	20,36	Apo-B	38,43	apolipoprotein-B	Apo-B	338	338	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The significance of apolipoprotein-B -LRB- Apo-B -RRB- in the elderly as a predictive factor of cardio-cerebrovascular_complications .
1597147	0	apolipoprotein-B	29,45	apoB	47,51	apolipoprotein-B	apoB	54225(Tax:10116)	54225(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Effects of growth_hormone on apolipoprotein-B -LRB- apoB -RRB- messenger ribonucleic acid editing , and apoB_48 and apoB_100 synthesis and secretion in the rat liver .
1770304	0	apolipoprotein_A-I	22,40	A-II	95,99	apolipoprotein A-I	A-II	335	114548	Gene	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	In vivo metabolism of apolipoprotein_A-I on high density lipoprotein particles LpA-I and LpA-I , A-II .
22389325	0	apolipoprotein_A-I	100,118	ABCA1	76,81	apolipoprotein A-I	ABCA1	335	19	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein_A-I in HepG2 cells .
17053191	0	apolipoprotein_A-I	46,64	ATP-Binding_cassette_transporter_A1	0,35	apolipoprotein A-I	ATP-Binding cassette transporter A1	335	19	Gene	Gene	transcytosis|compound|START_ENTITY modulates|dobj|transcytosis modulates|nsubj|END_ENTITY	ATP-Binding_cassette_transporter_A1 modulates apolipoprotein_A-I transcytosis through aortic endothelial cells .
12890677	0	apolipoprotein_A-I	40,58	ATP-binding_cassette_transporter_A1	102,137	apolipoprotein A-I	ATP-binding cassette transporter A1	100772590	100761226	Gene	Gene	START_ENTITY|advcl|increasing increasing|dobj|presence presence|nmod|END_ENTITY	Ceramide enhances cholesterol efflux to apolipoprotein_A-I by increasing the cell surface presence of ATP-binding_cassette_transporter_A1 .
14660648	0	apolipoprotein_A-I	37,55	ATP-binding_cassette_transporter_A1	74,109	apolipoprotein A-I	ATP-binding cassette transporter A1	335	19	Gene	Gene	physiology|nmod|START_ENTITY lipidation|nsubj|physiology lipidation|nmod|END_ENTITY	Molecular and cellular physiology of apolipoprotein_A-I lipidation by the ATP-binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- .
20208418	0	apolipoprotein_A-I	9,27	ATP-binding_cassette_transporter_A1	94,129	apolipoprotein A-I	ATP-binding cassette transporter A1	11806(Tax:10090)	11303(Tax:10090)	Gene	Gene	peptide|amod|START_ENTITY D-4F|appos|peptide promotes|nsubj|D-4F promotes|nmod|macrophages macrophages|nmod|END_ENTITY	D-4F , an apolipoprotein_A-I mimetic peptide , promotes cholesterol efflux from macrophages via ATP-binding_cassette_transporter_A1 .
21734188	0	apolipoprotein_A-I	6,24	ATP-binding_cassette_transporter_A1	120,155	apolipoprotein A-I	ATP-binding cassette transporter A1	335	19	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Human apolipoprotein_A-I induces cyclooxygenase-2 expression and prostaglandin_I-2 release in endothelial cells through ATP-binding_cassette_transporter_A1 .
22271762	0	apolipoprotein_A-I	11,29	ATP-binding_cassette_transporter_A1	41,76	apolipoprotein A-I	ATP-binding cassette transporter A1	335	19	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|xcomp|signaling signaling|nsubj|END_ENTITY	Endogenous apolipoprotein_A-I stabilizes ATP-binding_cassette_transporter_A1 and modulates Toll-like_receptor_4 signaling in human macrophages .
22399138	0	apolipoprotein_A-I	83,101	ATP-binding_cassette_transporter_A1	105,140	apolipoprotein A-I	ATP-binding cassette transporter A1	335	19	Gene	Gene	binding|nmod|START_ENTITY increasing|dobj|binding increasing|nmod|END_ENTITY	IMB2026791 , a xanthone , stimulates cholesterol efflux by increasing the binding of apolipoprotein_A-I to ATP-binding_cassette_transporter_A1 .
3142880	0	apolipoprotein_A-I	30,48	ApoA-I	50,56	apolipoprotein A-I	ApoA-I	335	335	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Tissue-specific expression of apolipoprotein_A-I -LRB- ApoA-I -RRB- is regulated by the 5 ' - flanking region of the human ApoA-I gene .
15345795	0	apolipoprotein_A-I	17,35	Apolipoprotein_B	0,16	apolipoprotein A-I	Apolipoprotein B	335	338	Gene	Gene	relation|dep|START_ENTITY END_ENTITY|dep|relation	Apolipoprotein_B / apolipoprotein_A-I in relation to the metabolic_syndrome and change in carotid artery intima-media_thickness during 3 years in middle-aged men .
18521458	0	apolipoprotein_A-I	17,35	Apolipoprotein_B	0,16	apolipoprotein A-I	Apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Apolipoprotein_B / apolipoprotein_A-I ratio in relation to various definitions of metabolic_syndrome among Saudi patients with type_2_diabetes_mellitus .
17824618	0	apolipoprotein_A-I	23,41	Haptoglobin	0,11	apolipoprotein A-I	Haptoglobin	335	3240	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Haptoglobin binding to apolipoprotein_A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase .
1900192	0	apolipoprotein_A-I	34,52	Hepatic_lipase	0,14	apolipoprotein A-I	Hepatic lipase	335	3990	Gene	Gene	loss|nmod|START_ENTITY promotes|dobj|loss promotes|nsubj|END_ENTITY	Hepatic_lipase promotes a loss of apolipoprotein_A-I from triglyceride-enriched human high density lipoproteins during incubation in vitro .
11018467	0	apolipoprotein_A-I	135,153	LCAT	168,172	apolipoprotein A-I	LCAT	25081(Tax:10116)	24530(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein_A-I transgenic rats is diminished through dose-dependent apolipoprotein_A-I activation of LCAT .
22219194	0	apolipoprotein_A-I	24,42	Myeloperoxidase	0,15	apolipoprotein A-I	Myeloperoxidase	335	4353	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Myeloperoxidase targets apolipoprotein_A-I , the major high density lipoprotein protein , for site-specific oxidation in human atherosclerotic_lesions .
12882972	0	apolipoprotein_A-I	26,44	NFkappaB	0,8	apolipoprotein A-I	NFkappaB	11806(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	NFkappaB regulates plasma apolipoprotein_A-I and high density lipoprotein cholesterol through inhibition of peroxisome_proliferator-activated_receptor_alpha .
25734982	0	apolipoprotein_A-I	38,56	PPARy	95,100	apolipoprotein A-I	PPARy	335	5468	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	A novel compound 4010B-30 upregulates apolipoprotein_A-I gene expression through activation of PPARy in HepG2 cells .
9278389	0	apolipoprotein_A-I	30,48	RORalpha	89,97	apolipoprotein A-I	RORalpha	11806(Tax:10090)	19883(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of apolipoprotein_A-I gene expression by the nuclear receptor RORalpha .
23894648	0	apolipoprotein_A-I	6,24	SR-BI	94,99	apolipoprotein A-I	SR-BI	335	949	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Human apolipoprotein_A-I is associated with dengue_virus_and_enhances_virus_infection through SR-BI .
23994331	0	apolipoprotein_A-I	44,62	Serum_amyloid_A	0,15	apolipoprotein A-I	Serum amyloid A	335	6287	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Serum_amyloid_A is independently related to apolipoprotein_A-I but not to HDL-cholesterol in patients with angina_pectoris .
24038215	0	apolipoprotein_A-I	14,32	TNF-alpha	47,56	apolipoprotein A-I	TNF-alpha	335	7124	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of apolipoprotein_A-I expression by TNF-alpha in HepG2 cells : requirement for c-jun .
1703299	0	apolipoprotein_A-I	101,119	apolipoprotein_A-I	20,38	apolipoprotein A-I	apolipoprotein A-I	11806(Tax:10090)	335	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of human apolipoprotein_A-I in transgenic_mice results in reduced plasma levels of murine apolipoprotein_A-I and the appearance of two new high density lipoprotein size subclasses .
1703299	0	apolipoprotein_A-I	20,38	apolipoprotein_A-I	101,119	apolipoprotein A-I	apolipoprotein A-I	335	11806(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of human apolipoprotein_A-I in transgenic_mice results in reduced plasma levels of murine apolipoprotein_A-I and the appearance of two new high density lipoprotein size subclasses .
3082628	0	apolipoprotein_A-I	103,121	apolipoprotein_A-II	64,83	apolipoprotein A-I	apolipoprotein A-II	335	336	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Stimulation of lecithin : cholesterol_acyltransferase activity by apolipoprotein_A-II in the presence of apolipoprotein_A-I .
2159462	0	apolipoprotein_A-I	35,53	apolipoprotein_A-IV	6,25	apolipoprotein A-I	apolipoprotein A-IV	335	337	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Human apolipoprotein_A-IV binds to apolipoprotein_A-I / A-II receptor sites and promotes cholesterol efflux from adipose cells .
8169653	0	apolipoprotein_A-I	103,121	apolipoprotein_A-IV	41,60	apolipoprotein A-I	apolipoprotein A-IV	25081(Tax:10116)	25080(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY lowers|dobj|mRNA lowers|nsubj|mRNA mRNA|amod|END_ENTITY	Cholestyramine and a fat-free diet lower apolipoprotein_A-IV mRNA in jejunum and cholestyramine lowers apolipoprotein_A-I mRNA in ileum of rats .
17631073	0	apolipoprotein_A-I	38,56	apolipoprotein_B	21,37	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY Relation|dep|ratio Relation|nmod|age age|appos|END_ENTITY	Relation of age , the apolipoprotein_B / apolipoprotein_A-I ratio , and the risk of fatal myocardial_infarction and implications for the primary prevention of cardiovascular_disease .
18676970	0	apolipoprotein_A-I	74,92	apolipoprotein_B	17,33	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY comparable|nmod|ratio comparable|nsubj|Concentration Concentration|nmod|END_ENTITY	Concentration of apolipoprotein_B is comparable with the apolipoprotein_B / apolipoprotein_A-I ratio and better than routine clinical lipid measurements in predicting coronary_heart_disease mortality : findings from a multi-ethnic US population .
18676970	0	apolipoprotein_A-I	74,92	apolipoprotein_B	57,73	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Concentration of apolipoprotein_B is comparable with the apolipoprotein_B / apolipoprotein_A-I ratio and better than routine clinical lipid measurements in predicting coronary_heart_disease mortality : findings from a multi-ethnic US population .
20102908	0	apolipoprotein_A-I	39,57	apolipoprotein_B	22,38	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY Relation|dep|ratio Relation|nmod|END_ENTITY	Relation of change in apolipoprotein_B / apolipoprotein_A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary_artery_disease .
23345015	0	apolipoprotein_A-I	22,40	apolipoprotein_B	5,21	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY BMI|dep|ratio BMI|amod|END_ENTITY	BMI , apolipoprotein_B / apolipoprotein_A-I ratio , and insulin resistance in patients with prolactinomas : a pilot study in a Chinese cohort .
23351584	0	apolipoprotein_A-I	140,158	apolipoprotein_B	123,139	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY variation|dep|ratio variation|dep|relationship relationship|nmod|events events|nmod|END_ENTITY	Common variation in cholesteryl_ester_transfer_protein : relationship of first major adverse cardiovascular events with the apolipoprotein_B / apolipoprotein_A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio .
23359805	0	apolipoprotein_A-I	53,71	apolipoprotein_B	11,27	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|parataxis|associated	Both serum apolipoprotein_B and the apolipoprotein_B / apolipoprotein_A-I ratio are associated with carotid_intima-media_thickness .
24940716	0	apolipoprotein_A-I	21,39	apolipoprotein_B	4,20	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	The apolipoprotein_B / apolipoprotein_A-I ratio in healthy men with normolipidemia : limits of variation and relationship with other lipid parameters .
25306891	0	apolipoprotein_A-I	43,61	apolipoprotein_B	26,42	apolipoprotein A-I	apolipoprotein B	335	338	Gene	Gene	ratio|compound|START_ENTITY value|dep|ratio value|nmod|END_ENTITY	Predictive value of serum apolipoprotein_B / apolipoprotein_A-I ratio in metabolic_syndrome risk : a Chinese cohort study .
22727790	0	apolipoprotein_A-I	14,32	aryl_hydrocarbon_receptor	45,70	apolipoprotein A-I	aryl hydrocarbon receptor	335	196	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Inhibition of apolipoprotein_A-I gene by the aryl_hydrocarbon_receptor : a potential mechanism for smoking-associated hypoalphalipoproteinemia .
21734188	0	apolipoprotein_A-I	6,24	cyclooxygenase-2	33,49	apolipoprotein A-I	cyclooxygenase-2	335	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Human apolipoprotein_A-I induces cyclooxygenase-2 expression and prostaglandin_I-2 release in endothelial cells through ATP-binding_cassette_transporter_A1 .
18783334	0	apolipoprotein_A-I	84,102	haptoglobin	120,131	apolipoprotein A-I	haptoglobin	335	3240	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Relevance of the amino_acid conversions L144R -LRB- Zaragoza -RRB- and L159P -LRB- Zavalla -RRB- in the apolipoprotein_A-I binding site for haptoglobin .
12796142	0	apolipoprotein_A-I	157,175	hepatic_lipase	20,34	apolipoprotein A-I	hepatic lipase	100009253(Tax:9986)	3990	Gene	Gene	triglyceride-enriched|nmod|START_ENTITY clearance|nmod|triglyceride-enriched enhances|dobj|clearance enhances|nsubj|Expression Expression|nmod|END_ENTITY	Expression of human hepatic_lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native high-density lipoprotein apolipoprotein_A-I .
2111173	0	apolipoprotein_A-I	67,85	hepatic_lipase	23,37	apolipoprotein A-I	hepatic lipase	100009253(Tax:9986)	100008678(Tax:9986)	Gene	Gene	concentration|nmod|START_ENTITY reduces|dobj|concentration reduces|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence in vitro that hepatic_lipase reduces the concentration of apolipoprotein_A-I in rabbit high-density lipoproteins .
25013403	0	apolipoprotein_A-I	54,72	hepatic_lipase	20,34	apolipoprotein A-I	hepatic lipase	335	3990	Gene	Gene	production|compound|START_ENTITY impacts|dobj|production impacts|nsubj|Expression Expression|nmod|END_ENTITY	Expression of human hepatic_lipase negatively impacts apolipoprotein_A-I production in primary hepatocytes from Lipc-null mice .
23299078	0	apolipoprotein_A-I	21,39	matrix_metalloproteinase-2	43,69	apolipoprotein A-I	matrix metalloproteinase-2	100009253(Tax:9986)	100009000(Tax:9986)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Inhibitory effect of apolipoprotein_A-I on matrix_metalloproteinase-2 expression in vivo and in vitro .
18082637	0	apolipoprotein_A-I	27,45	vitamin_D_receptor	65,83	apolipoprotein A-I	vitamin D receptor	335	7421	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Differential regulation of apolipoprotein_A-I gene expression by vitamin_D_receptor modulators .
3082628	0	apolipoprotein_A-II	64,83	apolipoprotein_A-I	103,121	apolipoprotein A-II	apolipoprotein A-I	336	335	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Stimulation of lecithin : cholesterol_acyltransferase activity by apolipoprotein_A-II in the presence of apolipoprotein_A-I .
2159462	0	apolipoprotein_A-IV	6,25	apolipoprotein_A-I	35,53	apolipoprotein A-IV	apolipoprotein A-I	337	335	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Human apolipoprotein_A-IV binds to apolipoprotein_A-I / A-II receptor sites and promotes cholesterol efflux from adipose cells .
8169653	0	apolipoprotein_A-IV	41,60	apolipoprotein_A-I	103,121	apolipoprotein A-IV	apolipoprotein A-I	25080(Tax:10116)	25081(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY lowers|nsubj|mRNA lowers|dobj|mRNA mRNA|amod|END_ENTITY	Cholestyramine and a fat-free diet lower apolipoprotein_A-IV mRNA in jejunum and cholestyramine lowers apolipoprotein_A-I mRNA in ileum of rats .
3095836	0	apolipoprotein_A4	53,70	APOA4	77,82	apolipoprotein A4	APOA4	337	337	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure , evolution , and polymorphisms of the human apolipoprotein_A4 gene -LRB- APOA4 -RRB- .
12937897	0	apolipoprotein_A5	51,68	APOA5	70,75	apolipoprotein A5	APOA5	116519	116519	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The single nucleotide polymorphism -1131 T > C in the apolipoprotein_A5 -LRB- APOA5 -RRB- gene is associated with elevated triglycerides in patients with hyperlipidemia .
16143024	0	apolipoprotein_A5	21,38	APOA5	40,45	apolipoprotein A5	APOA5	116519	116519	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the apolipoprotein_A5 -LRB- APOA5 -RRB- gene and type_III_hyperlipidemia .
16943456	0	apolipoprotein_A5	141,158	APOA5	160,165	apolipoprotein A5	APOA5	116519	116519	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparison of low-fat meal and high-fat meal on postprandial lipemic response in non-obese men according to the -1131 T > C polymorphism of the apolipoprotein_A5 -LRB- APOA5 -RRB- gene -LRB- randomized cross-over design -RRB- .
19056598	0	apolipoprotein_A5	62,79	APOA5	81,86	apolipoprotein A5	APOA5	116519	116519	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between glucokinase_regulatory_protein -LRB- GCKR -RRB- and apolipoprotein_A5 -LRB- APOA5 -RRB- gene polymorphisms and triacylglycerol concentrations in fasting , postprandial , and fenofibrate-treated states .
20688329	0	apolipoprotein_A5	4,21	APOA5	23,28	apolipoprotein A5	APOA5	116519	116519	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The apolipoprotein_A5 -LRB- APOA5 -RRB- gene predisposes Caucasian children to elevated triglycerides and vitamin_E -LRB- Four Provinces Study -RRB- .
21993410	0	apolipoprotein_A5	17,34	APOA5	36,41	apolipoprotein A5	APOA5	116519	116519	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Resequencing the apolipoprotein_A5 -LRB- APOA5 -RRB- gene in patients with various forms of hypertriglyceridemia .
15790933	0	apolipoprotein_A5	30,47	RORalpha	88,96	apolipoprotein A5	RORalpha	116519	6095	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of apolipoprotein_A5 gene expression by the nuclear receptor RORalpha .
1899293	0	apolipoprotein_AI	18,35	ARP-1	44,49	apolipoprotein AI	ARP-1	335	7026	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of the apolipoprotein_AI gene by ARP-1 , a novel member of the steroid receptor superfamily .
12614163	0	apolipoprotein_AI	21,38	Sp1	48,51	apolipoprotein AI	Sp1	335	6667	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Insulin induction of apolipoprotein_AI , role of Sp1 .
15375792	0	apolipoprotein_AI	17,34	Sp1	47,50	apolipoprotein AI	Sp1	335	6667	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Induction of the apolipoprotein_AI promoter by Sp1 is repressed by saturated_fatty_acids .
16475830	0	apolipoprotein_AI	14,31	tumor_necrosis_factor_alpha	51,78	apolipoprotein AI	tumor necrosis factor alpha	335	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of apolipoprotein_AI gene expression by tumor_necrosis_factor_alpha : roles for MEK/ERK and JNK signaling .
12136239	0	apolipoprotein_AII	35,53	APOA2	61,66	apolipoprotein AII	APOA2	336	336	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence polymorphism at the human apolipoprotein_AII gene -LRB- APOA2 -RRB- : unexpected deficit of variation in an African-American sample .
17634201	0	apolipoprotein_AIV	15,33	cholecystokinin	39,54	apolipoprotein AIV	cholecystokinin	25080(Tax:10116)	25298(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of apolipoprotein_AIV with cholecystokinin on the control of food intake .
22461023	0	apolipoprotein_AIV	73,91	cholecystokinin	39,54	apolipoprotein AIV	cholecystokinin	11808(Tax:10090)	12424(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY Effect|nmod|mice Effect|nmod|administration administration|nmod|END_ENTITY	Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein_AIV knockout mice .
8530390	0	apolipoprotein_AI_regulatory_protein-1	113,151	cholesteryl_ester_transfer_protein	34,68	apolipoprotein AI regulatory protein-1	cholesteryl ester transfer protein	7026	1071	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the cholesteryl_ester_transfer_protein gene by the orphan nuclear hormone receptor apolipoprotein_AI_regulatory_protein-1 .
19914667	0	apolipoprotein_B	45,61	A-1	65,68	apolipoprotein B	A-1	338	597	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|ratio ratio|compound|END_ENTITY	Adiponectin is independently associated with apolipoprotein_B to A-1 ratio in Koreans .
19914667	0	apolipoprotein_B	45,61	Adiponectin	0,11	apolipoprotein B	Adiponectin	338	9370	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Adiponectin is independently associated with apolipoprotein_B to A-1 ratio in Koreans .
9284903	0	apolipoprotein_B	69,85	ApoB	87,91	apolipoprotein B	ApoB	338	338	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Normal intestinal dietary fat and cholesterol absorption , intestinal apolipoprotein_B -LRB- ApoB -RRB- mRNA levels , and ApoB-48 synthesis in a hypobetalipoproteinemic kindred without any ApoB truncation .
7597652	0	apolipoprotein_B	71,87	Apob	89,93	apolipoprotein B	Apob	238055(Tax:10090)	238055(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exencephaly and hydrocephaly in mice with targeted modification of the apolipoprotein_B -LRB- Apob -RRB- gene .
22425626	0	apolipoprotein_B	20,36	Apolipoprotein_A-I	0,18	apolipoprotein B	Apolipoprotein A-I	338	335	Gene	Gene	C-reactive_protein|amod|START_ENTITY C-reactive_protein|amod|END_ENTITY	Apolipoprotein_A-I , apolipoprotein_B , high-sensitivity C-reactive_protein and severity of coronary_artery_disease in Tunisian population .
1756599	0	apolipoprotein_B	42,58	Apolipoprotein_B	0,16	apolipoprotein B	Apolipoprotein B	338	338	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|dobj|concentrations	Apolipoprotein_B polymorphism and altered apolipoprotein_B concentrations in Congolese blacks .
2312735	0	apolipoprotein_B	122,138	B-31	140,144	apolipoprotein B	B-31	338	9595	Gene	Gene	species|nmod|START_ENTITY results|nmod|species gene|acl:relcl|results gene|appos|END_ENTITY	Familial_hypobetalipoproteinemia caused by a mutation in the apolipoprotein_B gene that results in a truncated species of apolipoprotein_B -LRB- B-31 -RRB- .
2312735	0	apolipoprotein_B	61,77	B-31	140,144	apolipoprotein B	B-31	338	9595	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Familial_hypobetalipoproteinemia caused by a mutation in the apolipoprotein_B gene that results in a truncated species of apolipoprotein_B -LRB- B-31 -RRB- .
10469141	0	apolipoprotein_B	9,25	DNA_topoisomerase_I	54,73	apolipoprotein B	DNA topoisomerase I	338	64550(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nsubj|gene	Purified apolipoprotein_B gene regulatory factor-3 is DNA_topoisomerase_I .
3336367	0	apolipoprotein_B	68,84	DNase_I	0,7	apolipoprotein B	DNase I	338	13419(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY sites|nmod|gene sites|amod|END_ENTITY	DNase_I - and micrococcal nuclease-hypersensitive sites in the human apolipoprotein_B gene are tissue specific .
9162741	0	apolipoprotein_B	14,30	IL-6	44,48	apolipoprotein B	IL-6	338	3569	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Inhibition of apolipoprotein_B secretion by IL-6 is mediated by EGF or an EGF-like molecule in CaCo-2 cells .
10683382	0	apolipoprotein_B	32,48	LDL_receptor	16,28	apolipoprotein B	LDL receptor	238055(Tax:10090)	16835(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	The role of the LDL_receptor in apolipoprotein_B secretion .
6501314	0	apolipoprotein_B	86,102	Low-density_lipoprotein_receptor	0,32	apolipoprotein B	Low-density lipoprotein receptor	338	3949	Gene	Gene	switch|xcomp|START_ENTITY switch|nsubj|determinants determinants|amod|END_ENTITY	Low-density_lipoprotein_receptor binding determinants switch from apolipoprotein_E to apolipoprotein_B during conversion of hypertriglyceridemic very-low-density lipoprotein to low-density lipoproteins .
10705993	0	apolipoprotein_B	18,34	apoB	111,115	apolipoprotein B	apoB	238055(Tax:10090)	238055(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|amod|END_ENTITY	Regulation of the apolipoprotein_B in heterozygous_hypobetalipoproteinemic knock-out mice expressing truncated apoB , B81 .
2450346	0	apolipoprotein_B	6,22	apoB	24,28	apolipoprotein B	apoB	338	338	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Human apolipoprotein_B -LRB- apoB -RRB- mRNA : identification of two distinct apoB mRNAs , an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon , in both liver and intestine .
17631073	0	apolipoprotein_B	21,37	apolipoprotein_A-I	38,56	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	age|appos|START_ENTITY Relation|nmod|age Relation|dep|ratio ratio|compound|END_ENTITY	Relation of age , the apolipoprotein_B / apolipoprotein_A-I ratio , and the risk of fatal myocardial_infarction and implications for the primary prevention of cardiovascular_disease .
18676970	0	apolipoprotein_B	17,33	apolipoprotein_A-I	74,92	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	Concentration|nmod|START_ENTITY comparable|nsubj|Concentration comparable|nmod|ratio ratio|compound|END_ENTITY	Concentration of apolipoprotein_B is comparable with the apolipoprotein_B / apolipoprotein_A-I ratio and better than routine clinical lipid measurements in predicting coronary_heart_disease mortality : findings from a multi-ethnic US population .
18676970	0	apolipoprotein_B	57,73	apolipoprotein_A-I	74,92	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Concentration of apolipoprotein_B is comparable with the apolipoprotein_B / apolipoprotein_A-I ratio and better than routine clinical lipid measurements in predicting coronary_heart_disease mortality : findings from a multi-ethnic US population .
20102908	0	apolipoprotein_B	22,38	apolipoprotein_A-I	39,57	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	Relation|nmod|START_ENTITY Relation|dep|ratio ratio|compound|END_ENTITY	Relation of change in apolipoprotein_B / apolipoprotein_A-I ratio to coronary plaque regression after Pravastatin treatment in patients with coronary_artery_disease .
23345015	0	apolipoprotein_B	5,21	apolipoprotein_A-I	22,40	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	BMI|amod|START_ENTITY BMI|dep|ratio ratio|compound|END_ENTITY	BMI , apolipoprotein_B / apolipoprotein_A-I ratio , and insulin resistance in patients with prolactinomas : a pilot study in a Chinese cohort .
23351584	0	apolipoprotein_B	123,139	apolipoprotein_A-I	140,158	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	events|nmod|START_ENTITY relationship|nmod|events variation|dep|relationship variation|dep|ratio ratio|compound|END_ENTITY	Common variation in cholesteryl_ester_transfer_protein : relationship of first major adverse cardiovascular events with the apolipoprotein_B / apolipoprotein_A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio .
23359805	0	apolipoprotein_B	11,27	apolipoprotein_A-I	53,71	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	Both serum apolipoprotein_B and the apolipoprotein_B / apolipoprotein_A-I ratio are associated with carotid_intima-media_thickness .
24940716	0	apolipoprotein_B	4,20	apolipoprotein_A-I	21,39	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	The apolipoprotein_B / apolipoprotein_A-I ratio in healthy men with normolipidemia : limits of variation and relationship with other lipid parameters .
25306891	0	apolipoprotein_B	26,42	apolipoprotein_A-I	43,61	apolipoprotein B	apolipoprotein A-I	338	335	Gene	Gene	value|nmod|START_ENTITY value|dep|ratio ratio|compound|END_ENTITY	Predictive value of serum apolipoprotein_B / apolipoprotein_A-I ratio in metabolic_syndrome risk : a Chinese cohort study .
2310757	0	apolipoprotein_B	4,20	apolipoprotein_B	65,81	apolipoprotein B	apolipoprotein B	338	338	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Rat apolipoprotein_B differs in solubility properties from human apolipoprotein_B .
2310757	0	apolipoprotein_B	65,81	apolipoprotein_B	4,20	apolipoprotein B	apolipoprotein B	338	338	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Rat apolipoprotein_B differs in solubility properties from human apolipoprotein_B .
11093922	0	apolipoprotein_B	64,80	growth_hormone	18,32	apolipoprotein B	growth hormone	54225(Tax:10116)	81668(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Direct effects of growth_hormone on production and secretion of apolipoprotein_B from rat hepatocytes .
9921275	0	apolipoprotein_B	47,63	hepatic_nuclear_factor-4	15,39	apolipoprotein B	hepatic nuclear factor-4	338	3172	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Association of hepatic_nuclear_factor-4 in the apolipoprotein_B promoter : a preliminary report .
12031600	0	apolipoprotein_B	68,84	low-density_lipoprotein_receptor	88,120	apolipoprotein B	low-density lipoprotein receptor	338	3949	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of an asparagine to lysine mutation at amino_acid 3516 of apolipoprotein_B on low-density_lipoprotein_receptor binding .
12177061	0	apolipoprotein_B	61,77	transforming_growth_factor_beta	91,122	apolipoprotein B	transforming growth factor beta	338	7040	Gene	Gene	regulation|nmod|START_ENTITY secretion|nsubj|regulation secretion|nmod|END_ENTITY	Differential , tissue-specific , transcriptional regulation of apolipoprotein_B secretion by transforming_growth_factor_beta .
22906437	0	apolipoprotein_B-100	77,97	ORP10	0,5	apolipoprotein B-100	ORP10	338	114884	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	ORP10 , a cholesterol binding protein associated with microtubules , regulates apolipoprotein_B-100 secretion .
3767991	0	apolipoprotein_B-100	76,96	low_density_lipoprotein_receptor	18,50	apolipoprotein B-100	low density lipoprotein receptor	338	3949	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	Identification of low_density_lipoprotein_receptor binding domains of human apolipoprotein_B-100 : a proposed consensus LDL_receptor binding sequence of apoB-100 .
20030174	0	apolipoprotein_B-48	26,45	apoB-48	47,54	apolipoprotein B-48	apoB-48	338	338	Gene	Gene	significance|nmod|START_ENTITY significance|dep|END_ENTITY	-LSB- Clinical significance of apolipoprotein_B-48 -LRB- apoB-48 -RRB- in patients with thyroid_disease -RSB- .
15070948	0	apolipoprotein_B100	78,97	growth_hormone	11,25	apolipoprotein B100	growth hormone	338	2688	Gene	Gene	therapy|nmod|START_ENTITY therapy|amod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- replacement therapy on low-density lipoprotein apolipoprotein_B100 kinetics in adult patients with GH_deficiency : a stable isotope study .
11825674	0	apolipoprotein_C-I	26,44	APOC1	46,51	apolipoprotein C-I	APOC1	341	341	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic association of an apolipoprotein_C-I -LRB- APOC1 -RRB- gene polymorphism with late-onset Alzheimer 's _ disease .
3729948	0	apolipoprotein_C-II	74,93	lipoprotein_lipase	14,32	apolipoprotein C-II	lipoprotein lipase	344	4023	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of lipoprotein_lipase by N-alpha-palmitoyl -LRB- 56-79 -RRB- fragment of apolipoprotein_C-II .
8088778	0	apolipoprotein_C2-linked	4,28	Acl	30,33	apolipoprotein C2-linked	Acl	11425(Tax:10090)	11425(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The apolipoprotein_C2-linked -LRB- Acl -RRB- gene : a new gene within the mouse apolipoprotein_e-c1-c2 gene cluster .
10974550	0	apolipoprotein_CII	130,148	Apolipoprotein_CII	0,18	apolipoprotein CII	Apolipoprotein CII	344	100135886(Tax:8022)	Gene	Gene	active|nmod|START_ENTITY active|nsubj|END_ENTITY	Apolipoprotein_CII from rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- is functionally active but structurally very different from mammalian apolipoprotein_CII .
3095375	1	apolipoprotein_CIII	102,121	lipoprotein_lipase	179,197	apolipoprotein CIII	lipoprotein lipase	345	4023	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Evidence that apolipoprotein_CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein_lipase in vivo .
20920539	0	apolipoprotein_D	37,53	PACAP	0,5	apolipoprotein D	PACAP	11815(Tax:10090)	11516(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	PACAP up-regulates the expression of apolipoprotein_D in 3T3-L1 adipocytes .
7927949	0	apolipoprotein_D	52,68	interleukin-1_alpha	29,48	apolipoprotein D	interleukin-1 alpha	347	3552	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Potent stimulatory effect of interleukin-1_alpha on apolipoprotein_D and gross_cystic_disease_fluid_protein-15 expression in human breast-cancer cells .
8922411	0	apolipoprotein_E	42,58	AP-2	21,25	apolipoprotein E	AP-2	348	7020	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor AP-2 regulates human apolipoprotein_E gene expression in astrocytoma cells .
11315514	0	apolipoprotein_E	21,37	APOE	39,43	apolipoprotein E	APOE	348	348	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the apolipoprotein_E -LRB- APOE -RRB- gene in gerontopsychiatric patients .
12567264	0	apolipoprotein_E	35,51	APOE	53,57	apolipoprotein E	APOE	348	348	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A pooled case-control study of the apolipoprotein_E -LRB- APOE -RRB- gene in age-related maculopathy .
19058936	0	apolipoprotein_E	18,34	APOE	36,40	apolipoprotein E	APOE	348	348	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A polymorphism of apolipoprotein_E -LRB- APOE -RRB- gene is associated with age at_natural_menopause in Caucasian females .
23554593	0	apolipoprotein_E	12,28	APOE	30,34	apolipoprotein E	APOE	348	348	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of apolipoprotein_E -LRB- APOE -RRB- genotype in early_mild_cognitive_impairment -LRB- E-MCI -RRB- .
26898659	0	apolipoprotein_E	28,44	APOE	46,50	apolipoprotein E	APOE	348	348	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exploring the effect of the apolipoprotein_E -LRB- APOE -RRB- gene on executive function , working memory , and processing speed during the early recovery period following traumatic_brain_injury .
26912074	0	apolipoprotein_E	15,31	APOE	33,37	apolipoprotein E	APOE	348	348	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of apolipoprotein_E -LRB- APOE -RRB- polymorphisms with warfarin maintenance dose in a northern Han Chinese population .
26425011	0	apolipoprotein_E	10,26	APO_E	28,33	apolipoprotein E	APO E	348	348	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of apolipoprotein_E -LRB- APO_E -RRB- polymorphism on leptin in Alzheimer 's _ disease .
10532681	0	apolipoprotein_E	33,49	Angiotensin_II	0,14	apolipoprotein E	Angiotensin II	11816(Tax:10090)	11606(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY atherogenicity|nmod|mice atherogenicity|compound|END_ENTITY	Angiotensin_II atherogenicity in apolipoprotein_E deficient mice is associated with increased cellular cholesterol biosynthesis .
17785354	0	apolipoprotein_E	35,51	Angiotensin_II	0,14	apolipoprotein E	Angiotensin II	348	183	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates adipocyte apolipoprotein_E expression .
22020146	0	apolipoprotein_E	147,163	Angiotensin_II	0,14	apolipoprotein E	Angiotensin II	11816(Tax:10090)	11606(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY aortic_atherosclerotic_plaque|nmod|mice pathway|nmod|aortic_atherosclerotic_plaque expression|nmod|pathway induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces extracellular_matrix_metalloproteinase_inducer expression via an AT1R dependent pathway in aortic_atherosclerotic_plaque in apolipoprotein_E knockout mice .
10327190	0	apolipoprotein_E	13,29	ApoE	31,35	apolipoprotein E	ApoE	348	348	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Synthesis of apolipoprotein_E -LRB- ApoE -RRB- mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE .
11140944	0	apolipoprotein_E	84,100	ApoE	102,106	apolipoprotein E	ApoE	348	348	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Complex adaptive systems and human health : the influence of common genotypes of the apolipoprotein_E -LRB- ApoE -RRB- gene polymorphism and age on the relational order within a field of lipid metabolism traits .
16687490	0	apolipoprotein_E	26,42	ApoE	44,48	apolipoprotein E	ApoE	11816(Tax:10090)	11816(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Profile and regulation of apolipoprotein_E -LRB- ApoE -RRB- expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus .
18987181	0	apolipoprotein_E	10,26	ApoE	28,32	apolipoprotein E	ApoE	11816(Tax:10090)	11816(Tax:10090)	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of apolipoprotein_E -LRB- ApoE -RRB- polymorphism on brain ApoE levels .
21388338	0	apolipoprotein_E	14,30	ApoE	32,36	apolipoprotein E	ApoE	348	348	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of apolipoprotein_E -LRB- ApoE -RRB- genotype on biomarkers of amyloidogenesis , tau pathology and neurodegeneration in Alzheimer 's _ disease .
25890021	0	apolipoprotein_E	15,31	ApoE	33,37	apolipoprotein E	ApoE	348	348	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of apolipoprotein_E -LRB- ApoE -RRB- polymorphisms with risk of primary hyperuricemia in Uygur men , Xinjiang , China .
7251821	0	apolipoprotein_E	20,36	ApoE	38,42	apolipoprotein E	ApoE	348	348	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of apolipoprotein_E -LRB- ApoE -RRB- apoprotein levels in the various ApoE phenotypes .
9524247	0	apolipoprotein_E	30,46	ApoE	48,52	apolipoprotein E	ApoE	101112253	101112253	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the sheep apolipoprotein_E -LRB- ApoE -RRB- gene and allelic variations of the ApoE gene in scrapie Suffolk sheep .
25656378	0	apolipoprotein_E	23,39	Apo_E	41,46	apolipoprotein E	Apo E	348	348	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Lack of association of apolipoprotein_E -LRB- Apo_E -RRB- polymorphism with the prevalence of metabolic_syndrome : the National Heart , Lung and Blood Institute Family Heart Study .
2618138	0	apolipoprotein_E	114,130	Apo_E	132,137	apolipoprotein E	Apo E	348	348	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Methodologic studies of the isolation of VLDL using the lipoprotein precipitation reaction in the preparation of apolipoprotein_E -LRB- Apo_E -RRB- -RSB- .
10488140	0	apolipoprotein_E	43,59	Apolipoprotein_A-I	0,18	apolipoprotein E	Apolipoprotein A-I	348	335	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Apolipoprotein_A-I stimulates secretion of apolipoprotein_E by foam cell macrophages .
2266137	0	apolipoprotein_E	48,64	Apolipoprotein_C-I	0,18	apolipoprotein E	Apolipoprotein C-I	348	341	Gene	Gene	interaction|nmod|START_ENTITY modulates|dobj|interaction modulates|nsubj|END_ENTITY	Apolipoprotein_C-I modulates the interaction of apolipoprotein_E with beta-migrating very low density lipoproteins -LRB- beta-VLDL -RRB- and inhibits binding of beta-VLDL to low density lipoprotein_receptor-related_protein .
12166499	0	apolipoprotein_E	138,154	HLA-DRB1	99,107	apolipoprotein E	HLA-DRB1	348	3123	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Disease severity in Danish multiple_sclerosis patients evaluated by MRI and three genetic markers -LRB- HLA-DRB1 * 1501 , CCR5 deletion mutation , apolipoprotein_E -RRB- .
19457062	0	apolipoprotein_E	18,34	Haptoglobin	0,11	apolipoprotein E	Haptoglobin	348	3240	Gene	Gene	esterification|amod|START_ENTITY binds|dobj|esterification binds|nsubj|END_ENTITY	Haptoglobin binds apolipoprotein_E and influences cholesterol esterification in the cerebrospinal fluid .
19758344	0	apolipoprotein_E	46,62	Haptoglobin	0,11	apolipoprotein E	Haptoglobin	348	3240	Gene	Gene	binds|dep|START_ENTITY binds|compound|END_ENTITY	Haptoglobin binds the antiatherogenic protein apolipoprotein_E - impairment of apolipoprotein_E stimulation of both lecithin : cholesterol_acyltransferase activity and cholesterol uptake by hepatocytes .
19758344	0	apolipoprotein_E	79,95	Haptoglobin	0,11	apolipoprotein E	Haptoglobin	348	3240	Gene	Gene	stimulation|amod|START_ENTITY impairment|nmod|stimulation binds|dep|impairment binds|compound|END_ENTITY	Haptoglobin binds the antiatherogenic protein apolipoprotein_E - impairment of apolipoprotein_E stimulation of both lecithin : cholesterol_acyltransferase activity and cholesterol uptake by hepatocytes .
25058565	0	apolipoprotein_E	27,43	Haptoglobin	0,11	apolipoprotein E	Haptoglobin	348	3240	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Haptoglobin interacts with apolipoprotein_E and beta-amyloid and influences their crosstalk .
8468529	0	apolipoprotein_E	71,87	Hepatic_lipase	0,14	apolipoprotein E	Hepatic lipase	25728(Tax:10116)	24538(Tax:10116)	Gene	Gene	exposure|nmod|START_ENTITY increases|dobj|exposure increases|nsubj|treatment treatment|amod|END_ENTITY	Hepatic_lipase treatment of chylomicron remnants increases exposure of apolipoprotein_E .
18475480	0	apolipoprotein_E	27,43	IL-1beta	0,8	apolipoprotein E	IL-1beta	25728(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression modulate|nsubj|END_ENTITY	IL-1beta and IL-6 modulate apolipoprotein_E gene expression in rat hepatocyte primary culture .
1744074	0	apolipoprotein_E	36,52	LDL_receptor	68,80	apolipoprotein E	LDL receptor	348	3949	Gene	Gene	START_ENTITY|acl:relcl|binds binds|dobj|END_ENTITY	A synthetic peptide mimic of plasma apolipoprotein_E that binds the LDL_receptor .
16953297	0	apolipoprotein_E	73,89	PrP	27,30	apolipoprotein E	PrP	348	5621	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	Recombinant neural protein PrP can bind with both recombinant and native apolipoprotein_E in vitro .
21372127	0	apolipoprotein_E	37,53	STAT1	73,78	apolipoprotein E	STAT1	348	6772	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Macrophage-specific up-regulation of apolipoprotein_E gene expression by STAT1 is achieved via long range genomic interactions .
15264223	0	apolipoprotein_E	11,27	Tat	72,75	apolipoprotein E	Tat	348	6898	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of apolipoprotein_E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes .
24530901	0	apolipoprotein_E	73,89	Th2	57,60	apolipoprotein E	Th2	11816(Tax:10090)	15111(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Allergic_asthma accelerates atherosclerosis dependent on Th2 and Th17 in apolipoprotein_E deficient mice .
9831625	0	apolipoprotein_E	15,31	alpha2-macroglobulin	37,57	apolipoprotein E	alpha2-macroglobulin	348	2	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of apolipoprotein_E with alpha2-macroglobulin in human plasma .
14505229	0	apolipoprotein_E	106,122	apoE	124,128	apolipoprotein E	apoE	348	348	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Log-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein_E -LRB- apoE -RRB- gene in Alzheimer 's _ disease .
15936307	0	apolipoprotein_E	10,26	apoE	28,32	apolipoprotein E	apoE	348	348	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of apolipoprotein_E -LRB- apoE -RRB- phenotype on the apoE content of CSF-HDL in children .
9058415	0	apolipoprotein_E	17,33	apoE	35,39	apolipoprotein E	apoE	348	348	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Increased plasma apolipoprotein_E -LRB- apoE -RRB- levels in Alzheimer 's _ disease .
9223597	0	apolipoprotein_E	20,36	apoE	38,42	apolipoprotein E	apoE	348	348	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Cerebrospinal fluid apolipoprotein_E -LRB- apoE -RRB- levels in Alzheimer 's _ disease patients are increased at follow up and show a correlation with levels of tau protein .
26468283	0	apolipoprotein_E	41,57	factor_H	11,19	apolipoprotein E	factor H	348	3075	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Complement factor_H binds to human serum apolipoprotein_E and mediates complement regulation on high-density lipoprotein particles .
3606467	0	apolipoprotein_E	35,51	familial_hypercholesterolemia	55,84	apolipoprotein E	familial hypercholesterolemia	348	3949	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Plasma lipoprotein distribution of apolipoprotein_E in familial_hypercholesterolemia .
2036455	0	apolipoprotein_E	73,89	hepatic_lipase	14,28	apolipoprotein E	hepatic lipase	348	3990	Gene	Gene	catalyzed|nmod|START_ENTITY catalyzed|nsubj|Activation Activation|nmod|END_ENTITY	Activation of hepatic_lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein_E .
3591946	0	apolipoprotein_E	13,29	hepatic_lipase	65,79	apolipoprotein E	hepatic lipase	348	3990	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of apolipoprotein_E on soluble and heparin-immobilized hepatic_lipase .
9075616	0	apolipoprotein_E	111,127	hepatic_triglyceride_lipase	42,69	apolipoprotein E	hepatic triglyceride lipase	348	3990	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen replacement therapy on hepatic_triglyceride_lipase , lipoprotein_lipase and lipids including apolipoprotein_E in climacteric and elderly women .
2072040	0	apolipoprotein_E	14,30	high_density_lipoprotein_3	44,70	apolipoprotein E	high density lipoprotein 3	11816(Tax:10090)	114576(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of apolipoprotein_E secretion by high_density_lipoprotein_3 in mouse macrophages .
15079806	0	apolipoprotein_E	54,70	interleukin-1_alpha	72,91	apolipoprotein E	interleukin-1 alpha	348	3552	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	-LSB- Analysis on association between the polymorphisms in apolipoprotein_E , interleukin-1_alpha genes and Alzheimer 's _ disease in Chengdu area -RSB- .
2597674	0	apolipoprotein_E	31,47	lecithin-cholesterol_acyltransferase	76,112	apolipoprotein E	lecithin-cholesterol acyltransferase	348	3931	Gene	Gene	containing|dobj|START_ENTITY containing|nmod|END_ENTITY	Discoidal complexes containing apolipoprotein_E and their transformation by lecithin-cholesterol_acyltransferase .
3926761	0	apolipoprotein_E	60,76	lecithin_cholesterol_acyltransferase	14,50	apolipoprotein E	lecithin cholesterol acyltransferase	348	3931	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of lecithin_cholesterol_acyltransferase by human apolipoprotein_E in discoidal complexes with lipids .
19481557	0	apolipoprotein_E	17,33	leptin	37,43	apolipoprotein E	leptin	11816(Tax:10090)	16846(Tax:10090)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of apolipoprotein_E by leptin in the hypothalamus of mice and rats .
10089402	0	apolipoprotein_E	120,136	low-density_lipoprotein-receptor	69,101	apolipoprotein E	low-density lipoprotein-receptor	348	3949	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density_lipoprotein-receptor binding region of apolipoprotein_E refined at 1.9 A .
15059809	0	apolipoprotein_E	96,112	low-density_lipoprotein_receptor	116,148	apolipoprotein E	low-density lipoprotein receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Lack of complement factor C3 , but not factor B , increases hyperlipidemia and atherosclerosis in apolipoprotein_E - / - low-density_lipoprotein_receptor - / - mice .
16297155	0	apolipoprotein_E	52,68	low-density_lipoprotein_receptor	72,104	apolipoprotein E	low-density lipoprotein receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Immunoglobulin treatment reduces atherosclerosis in apolipoprotein_E - / - low-density_lipoprotein_receptor - / - mice via the complement system .
10906325	0	apolipoprotein_E	98,114	low_density_lipoprotein_receptor	41,73	apolipoprotein E	low density lipoprotein receptor	348	3949	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The lipid-associated conformation of the low_density_lipoprotein_receptor binding domain of human apolipoprotein_E .
11546779	0	apolipoprotein_E	74,90	low_density_lipoprotein_receptor	129,161	apolipoprotein E	low density lipoprotein receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	lipoproteins|nmod|START_ENTITY production|nmod|lipoproteins Stimulation|nmod|production independent|nsubj|Stimulation independent|nmod|presence presence|nmod|END_ENTITY	Stimulation of the in vivo production of very low density lipoproteins by apolipoprotein_E is independent of the presence of the low_density_lipoprotein_receptor .
15888448	0	apolipoprotein_E	100,116	low_density_lipoprotein_receptor	4,36	apolipoprotein E	low density lipoprotein receptor	11816(Tax:10090)	3949	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The low_density_lipoprotein_receptor regulates the level of central nervous system human and murine apolipoprotein_E but does not modify amyloid plaque pathology in PDAPP mice .
17079229	0	apolipoprotein_E	27,43	low_density_lipoprotein_receptor	68,100	apolipoprotein E	low density lipoprotein receptor	348	3949	Gene	Gene	helix|compound|START_ENTITY extension|nmod|helix correlates|nsubj|extension correlates|nmod|ability ability|compound|END_ENTITY	Lipid-induced extension of apolipoprotein_E helix 4 correlates with low_density_lipoprotein_receptor binding ability .
8051153	0	apolipoprotein_E	18,34	low_density_lipoprotein_receptor	72,104	apolipoprotein E	low density lipoprotein receptor	348	3949	Gene	Gene	peptide|nsubj|START_ENTITY peptide|ccomp|mediates mediates|xcomp|binding binding|nmod|END_ENTITY	A nonexchangeable apolipoprotein_E peptide that mediates binding to the low_density_lipoprotein_receptor .
9664080	0	apolipoprotein_E	86,102	low_density_lipoprotein_receptor	24,56	apolipoprotein E	low density lipoprotein receptor	11816(Tax:10090)	16835(Tax:10090)	Gene	Gene	overexpressing|dobj|START_ENTITY lowering|advcl|overexpressing lowering|nmod|mice mice|compound|END_ENTITY	Cholesterol lowering in low_density_lipoprotein_receptor knockout mice overexpressing apolipoprotein_E .
9748256	0	apolipoprotein_E	60,76	low_density_lipoprotein_receptor	4,36	apolipoprotein E	low density lipoprotein receptor	348	3949	Gene	Gene	conformation|nmod|START_ENTITY END_ENTITY|dep|conformation	The low_density_lipoprotein_receptor active conformation of apolipoprotein_E .
12702516	0	apolipoprotein_E	97,113	natriuretic_peptide_receptor_A	64,94	apolipoprotein E	natriuretic peptide receptor A	11816(Tax:10090)	18160(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic_peptide_receptor_A - / - apolipoprotein_E - / - mice .
23958245	0	apolipoprotein_E	63,79	paraoxonase-1	35,48	apolipoprotein E	paraoxonase-1	348	5444	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The positive relationship of serum paraoxonase-1 activity with apolipoprotein_E is abrogated in metabolic_syndrome .
11732920	0	apolipoprotein_E4	52,69	Abeta	95,100	apolipoprotein E4	Abeta	348	351	Gene	Gene	START_ENTITY|nmod|peptide peptide|compound|END_ENTITY	Melatonin reverses the profibrillogenic activity of apolipoprotein_E4 on the Alzheimer amyloid Abeta peptide .
24381170	0	apolipoprotein_E_receptor_2	26,53	Clusterin	0,9	apolipoprotein E receptor 2	Clusterin	7804	1191	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Clusterin is a ligand for apolipoprotein_E_receptor_2 -LRB- ApoER2 -RRB- and very_low_density_lipoprotein_receptor -LRB- VLDLR -RRB- and signals via the Reelin-signaling pathway .
19661487	0	apolipoprotein_E_receptor_2	65,92	coagulation_factor_XI	18,39	apolipoprotein E receptor 2	coagulation factor XI	16975(Tax:10090)	109821(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of coagulation_factor_XI as a ligand for platelet apolipoprotein_E_receptor_2 -LRB- ApoER2 -RRB- .
25726912	0	apolipoprotein_F	34,50	ApoF	52,56	apolipoprotein F	ApoF	319	319	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the apolipoprotein_F -LRB- ApoF -RRB- gene by ETS and C/EBPa in hepatoma cells .
25726912	0	apolipoprotein_F	34,50	ApoF	52,56	apolipoprotein F	ApoF	319	319	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the apolipoprotein_F -LRB- ApoF -RRB- gene by ETS and C/EBPa in hepatoma cells .
18676959	0	apolipoprotein_H	28,44	APOH	51,55	apolipoprotein H	APOH	350	350	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Comprehensive evaluation of apolipoprotein_H gene -LRB- APOH -RRB- variation identifies novel associations with measures of lipid metabolism in GENOA .
9878186	0	apolipoprotein_J	11,27	Clusterin	0,9	apolipoprotein J	Clusterin	1191	1191	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Clusterin -LRB- apolipoprotein_J -RRB- protein levels are increased in hippocampus and in frontal cortex in Alzheimer 's _ disease .
11281639	0	apolipoprotein_J	78,94	clusterin	96,105	apolipoprotein J	clusterin	1191	1191	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Apoptotic cell debris and phosphatidylserine-containing lipid vesicles induce apolipoprotein_J -LRB- clusterin -RRB- gene expression in vital fibroblasts .
25136257	0	apolipoprotein_M	23,39	Apom	41,45	apolipoprotein M	Apom	55939(Tax:10116)	55939(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Rosiglitazone enhances apolipoprotein_M -LRB- Apom -RRB- expression in rat 's liver .
17977826	0	apolipoprotein_M	31,47	LRH-1	95,100	apolipoprotein M	LRH-1	55937	2494	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of anti-atherogenic apolipoprotein_M gene expression by the orphan nuclear receptor LRH-1 .
16099815	0	apolipoprotein_M	26,42	Megalin	0,7	apolipoprotein M	Megalin	55939(Tax:10116)	29216(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Megalin is a receptor for apolipoprotein_M , and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein_M .
22877565	0	apolipoprotein_M	49,65	Vascular_endothelial_growth_factor	0,34	apolipoprotein M	Vascular endothelial growth factor	55938(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor downregulates apolipoprotein_M expression by inhibiting Foxa2 in a Nur77-dependent manner .
21122852	0	apolipoprotein_M	23,39	proprotein_convertase_subtilisin-kexin_type_9	45,90	apolipoprotein M	proprotein convertase subtilisin-kexin type 9	55937	255738	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Relationship of plasma apolipoprotein_M with proprotein_convertase_subtilisin-kexin_type_9 levels in non-diabetic subjects .
25341235	0	apolipoprotein_a-I	17,35	Apolipoprotein_b	0,16	apolipoprotein a-I	Apolipoprotein b	335	338	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Apolipoprotein_b / apolipoprotein_a-I ratio in relation to the metabolic_syndrome , its components , total cholesterol and low-density lipoprotein cholesterol in the population of georgia .
24949011	0	apolipoprotein_a-I	36,54	apolipoprotein_b	19,35	apolipoprotein a-I	apolipoprotein b	335	338	Gene	Gene	ratio|compound|START_ENTITY Association|parataxis|ratio Association|nmod|END_ENTITY	Association of the apolipoprotein_b / apolipoprotein_a-I ratio , metabolic_syndrome components , total cholesterol , and low-density lipoprotein cholesterol with insulin resistance in the population of georgia .
24949011	0	apolipoprotein_b	19,35	apolipoprotein_a-I	36,54	apolipoprotein b	apolipoprotein a-I	338	335	Gene	Gene	Association|nmod|START_ENTITY Association|parataxis|ratio ratio|compound|END_ENTITY	Association of the apolipoprotein_b / apolipoprotein_a-I ratio , metabolic_syndrome components , total cholesterol , and low-density lipoprotein cholesterol with insulin resistance in the population of georgia .
14761944	0	apoptosis-antagonizing_transcription_factor	22,65	TSG101	0,6	apoptosis-antagonizing transcription factor	TSG101	26574	7251	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TSG101 interacts with apoptosis-antagonizing_transcription_factor and enhances androgen_receptor-mediated transcription by promoting its monoubiquitination .
17207087	0	apoptosis-inducing_factor	47,72	AIF	74,77	apoptosis-inducing factor	AIF	9131	9131	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical and mutational analysis of apoptosis-inducing_factor -LRB- AIF -RRB- in colorectal_carcinomas .
15983031	0	apoptosis-inducing_factor	63,88	caspase-2	14,23	apoptosis-inducing factor	caspase-2	9131	835	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing_factor and its role in renal tubular epithelial cell injury .
10229231	0	apoptosis-linked_gene_4	54,77	Fas_ligand	14,24	apoptosis-linked gene 4	Fas ligand	22984	356	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of Fas_ligand expression and cell death by apoptosis-linked_gene_4 .
24915960	0	apoptosis_inducing_factor	18,43	AIF	45,48	apoptosis inducing factor	AIF	26926(Tax:10090)	26926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of apoptosis_inducing_factor -LRB- AIF -RRB- is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer 's _ disease .
24338479	0	apoptosis_regulator_through_modulating_IAP_expression	78,131	Akt	61,64	apoptosis regulator through modulating IAP expression	Akt	68545(Tax:10090)	11651(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Manipulation of cardiac phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling by apoptosis_regulator_through_modulating_IAP_expression -LRB- ARIA -RRB- regulates cardiomyocyte_death during doxorubicin-induced cardiomyopathy .
14684425	0	apoptosis_signal-regulating_kinase-1	15,51	monocyte_chemoattractant_protein-1	78,112	apoptosis signal-regulating kinase-1	monocyte chemoattractant protein-1	365057(Tax:10116)	24770(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of apoptosis_signal-regulating_kinase-1 on angiotensin_II-induced monocyte_chemoattractant_protein-1 expression .
12165419	0	apoptosis_signal-regulating_kinase_1	38,74	ASK1	76,80	apoptosis signal-regulating kinase 1	ASK1	365057(Tax:10116)	365057(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation and autophosphorylation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- following cerebral_ischemia in rat hippocampus .
25882527	0	apoptosis_signal-regulating_kinase_1	18,54	ASK1	56,60	apoptosis signal-regulating kinase 1	ASK1	4217	4217	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Identification of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1 ,5 - dihydro-pyrrol-2-one .
9743501	0	apoptosis_signal-regulating_kinase_1	14,50	ASK1	52,56	apoptosis signal-regulating kinase 1	ASK1	4217	4217	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by the adapter protein Daxx .
19069379	0	apoptosis_signal-regulating_kinase_1	9,45	ASK_1	47,52	apoptosis signal-regulating kinase 1	ASK 1	4217	4217	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	-LSB- Role of apoptosis_signal-regulating_kinase_1 -LRB- ASK_1 -RRB- - mediated signaling pathway during ischemic_retinal_injury -RSB- .
9743501	0	apoptosis_signal-regulating_kinase_1	14,50	Daxx	81,85	apoptosis signal-regulating kinase 1	Daxx	4217	1616	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by the adapter protein Daxx .
17543279	0	apoptosis_signal-regulating_kinase_1	17,53	Ghrelin	0,7	apoptosis signal-regulating kinase 1	Ghrelin	365057(Tax:10116)	59301(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Ghrelin inhibits apoptosis_signal-regulating_kinase_1 activity via upregulating heat-shock_protein_70 .
19940360	0	apoptosis_signal-regulating_kinase_1	61,97	caspase-8	133,142	apoptosis signal-regulating kinase 1	caspase-8	4217	841	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Fas-induced apoptosis of renal_cell_carcinoma is mediated by apoptosis_signal-regulating_kinase_1 via mitochondrial damage-dependent caspase-8 activation .
20358250	0	apoptosis_signal-regulating_kinase_1	23,59	dual-specificity_phosphatase_13A	63,95	apoptosis signal-regulating kinase 1	dual-specificity phosphatase 13A	4217	51207	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive regulation of apoptosis_signal-regulating_kinase_1 by dual-specificity_phosphatase_13A .
11096076	0	apoptosis_signal-regulating_kinase_1	87,123	glutaminyl-tRNA_synthetase	55,81	apoptosis signal-regulating kinase 1	glutaminyl-tRNA synthetase	4217	5859	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA_synthetase with apoptosis_signal-regulating_kinase_1 .
12723971	0	apoptosis_signal-regulating_kinase_1	102,138	glutaredoxin	21,33	apoptosis signal-regulating kinase 1	glutaredoxin	4217	2745	Gene	Gene	activation|nmod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis_signal-regulating_kinase_1 .
12391142	0	apoptosis_signal-regulating_kinase_1	52,88	hsp72	19,24	apoptosis signal-regulating kinase 1	hsp72	26408(Tax:10090)	193740(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Heat_shock protein hsp72 is a negative regulator of apoptosis_signal-regulating_kinase_1 .
17456047	0	apoptosis_signal-regulating_kinase_1	14,50	protein_phosphatase_2Cepsilon	54,83	apoptosis signal-regulating kinase 1	protein phosphatase 2Cepsilon	4217	151742	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of apoptosis_signal-regulating_kinase_1 by protein_phosphatase_2Cepsilon .
12708028	0	apoptosis_signal-regulating_kinase_2	53,89	ASK_2	91,96	apoptosis signal-regulating kinase 2	ASK 2	53608(Tax:10090)	53608(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Genomic organization and promoter analysis of mouse apoptosis_signal-regulating_kinase_2 -LRB- ASK_2 -RRB- -RSB- .
21183427	0	apoptosis_stimulating_protein	37,66	ASPP-2	68,74	apoptosis stimulating protein	ASPP-2	7159	7159	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cell type specific expression of the apoptosis_stimulating_protein -LRB- ASPP-2 -RRB- in human tissues .
10342853	0	apoptotic_protease-activating_factor-1	54,92	Apaf-1	94,100	apoptotic protease-activating factor-1	Apaf-1	11783(Tax:10090)	11783(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Localization , regulation and possible consequences of apoptotic_protease-activating_factor-1 -LRB- Apaf-1 -RRB- expression in granulosa cells of the mouse ovary .
18197610	0	apoptotic_protease-activating_factor_1	38,76	Apaf-1	78,84	apoptotic protease-activating factor 1	Apaf-1	78963(Tax:10116)	78963(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Modulation of cellular apoptosis with apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- inhibitors .
23183622	0	aprataxin	24,33	APTX	35,39	aprataxin	APTX	54840	54840	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the aprataxin -LRB- APTX -RRB- gene in an Iranian individual suffering early-onset ataxia with oculomotor_apraxia_type_1 -LRB- AOA1 -RRB- _ disease .
7512520	0	aprotinin	20,29	plasmin	49,56	aprotinin	plasmin	404172(Tax:9913)	280897(Tax:9913)	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Plasmin modulators , aprotinin and anti-catalytic plasmin antibody , efficiently inhibit destruction of bovine vascular endothelial cells by choriocarcinoma cells .
15210853	0	apurinic_endonuclease_1	6,29	APE1	31,35	apurinic endonuclease 1	APE1	328	328	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Human apurinic_endonuclease_1 -LRB- APE1 -RRB- expression and prognostic significance in osteosarcoma : enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition .
16672223	0	aquaglyceroporin_3	91,109	multidrug_resistance-associated_protein_2	23,64	aquaglyceroporin 3	multidrug resistance-associated protein 2	360	1244	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	Enhanced expression of multidrug_resistance-associated_protein_2 and reduced expression of aquaglyceroporin_3 in an arsenic-resistant human cell line .
12600999	0	aquaporin-1	22,33	AQP1	35,39	aquaporin-1	AQP1	11826(Tax:10090)	11826(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Hypertonicity-induced aquaporin-1 -LRB- AQP1 -RRB- expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene .
15351300	0	aquaporin-1	12,23	AQP1	25,29	aquaporin-1	AQP1	11826(Tax:10090)	11826(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The role of aquaporin-1 -LRB- AQP1 -RRB- expression in a murine model of lipopolysaccharide-induced acute_lung_injury .
24231830	0	aquaporin-1	85,96	aquaporin-4	65,76	aquaporin-1	aquaporin-4	11826(Tax:10090)	11829(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4 , not by aquaporin-1 : 17O JJVCPE MRI study in knockout mice .
18032798	0	aquaporin-2	48,59	Calcium-sensing_receptor	0,24	aquaporin-2	Calcium-sensing receptor	11827(Tax:10090)	12374(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Calcium-sensing_receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism .
9125153	0	aquaporin-2	14,25	GATA-3	48,54	aquaporin-2	GATA-3	25386(Tax:10116)	85471(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of aquaporin-2 gene transcription by GATA-3 .
16641150	0	aquaporin-2	74,85	Tonicity-responsive_enhancer_binding_protein	0,44	aquaporin-2	Tonicity-responsive enhancer binding protein	11827(Tax:10090)	54446(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Tonicity-responsive_enhancer_binding_protein is an essential regulator of aquaporin-2 expression in renal collecting duct principal cells .
21110398	0	aquaporin-2	81,92	aquaporin-3	102,113	aquaporin-2	aquaporin-3	11827(Tax:10090)	11828(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin-2 and skin aquaporin-3 in KKAy mice .
15671070	0	aquaporin-2	28,39	arginine_vasopressin	66,86	aquaporin-2	arginine vasopressin	11827(Tax:10090)	11998(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Hypertonicity regulates the aquaporin-2 promoter independently of arginine_vasopressin .
19080694	0	aquaporin-2	48,59	erythropoietin	12,26	aquaporin-2	erythropoietin	25386(Tax:10116)	24335(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of erythropoietin on the expression of aquaporin-2 after renal_ischemia-reperfusion injury : experiment with rats -RSB- .
12669273	0	aquaporin-2	21,32	vasopressin	64,75	aquaporin-2	vasopressin	359	551	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Urinary excretion of aquaporin-2 and inappropriate secretion of vasopressin in hyponatremic patients after cerebral_infarction .
15248066	0	aquaporin-3	26,37	AQP3	39,43	aquaporin-3	AQP3	65133(Tax:10116)	65133(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Bronchiolar expression of aquaporin-3 -LRB- AQP3 -RRB- in rat lung and its dynamics in pulmonary_oedema .
21110398	0	aquaporin-3	102,113	aquaporin-2	81,92	aquaporin-3	aquaporin-2	11828(Tax:10090)	11827(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin-2 and skin aquaporin-3 in KKAy mice .
18836575	0	aquaporin-4	18,29	AQP4	31,35	aquaporin-4	AQP4	361	361	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Changes in ocular aquaporin-4 -LRB- AQP4 -RRB- expression following retinal_injury .
21255222	0	aquaporin-4	14,25	CD25	34,38	aquaporin-4	CD25	11829(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Novel role of aquaporin-4 in CD4 + CD25 + T regulatory cell development and severity of Parkinson 's _ disease .
21255222	0	aquaporin-4	14,25	CD4	29,32	aquaporin-4	CD4	11829(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Novel role of aquaporin-4 in CD4 + CD25 + T regulatory cell development and severity of Parkinson 's _ disease .
21371524	0	aquaporin-4	61,72	S100B	20,25	aquaporin-4	S100B	361	6285	Gene	Gene	autoimmune_syndrome|amod|START_ENTITY Usefulness|nmod|autoimmune_syndrome Usefulness|nmod|END_ENTITY	Usefulness of serum S100B as a marker for the acute phase of aquaporin-4 autoimmune_syndrome .
23142267	0	aquaporin-4	27,38	S100B	49,54	aquaporin-4	S100B	25293(Tax:10116)	25742(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Non-specific inhibitors of aquaporin-4 stimulate S100B secretion in acute hippocampal slices of rats .
21968684	0	aquaporin-4	14,25	VEGF	110,114	aquaporin-4	VEGF	361	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin-4 in human supratentorial_meningiomas with peritumoral brain_edema and correlation of VEGF with edema formation .
17927773	0	aquaporin-4	81,92	agrin	11,16	aquaporin-4	agrin	11829(Tax:10090)	11603(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of agrin on the expression and distribution of the water channel protein aquaporin-4 and volume regulation in cultured astrocytes .
24231830	0	aquaporin-4	65,76	aquaporin-1	85,96	aquaporin-4	aquaporin-1	11829(Tax:10090)	11826(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4 , not by aquaporin-1 : 17O JJVCPE MRI study in knockout mice .
18449356	0	aquaporin-5	35,46	AQP5	48,52	aquaporin-5	AQP5	362	362	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Comparative expression analysis of aquaporin-5 -LRB- AQP5 -RRB- in keratoconic and healthy corneas .
18768929	0	aquaporin-5	46,57	GATA-6	0,6	aquaporin-5	GATA-6	11830(Tax:10090)	14465(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1 .
17108010	0	aquaporin-5	24,35	hypoxia-inducible_factor-1alpha	51,82	aquaporin-5	hypoxia-inducible factor-1alpha	25241(Tax:10116)	29560(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|dep|role role|nmod|END_ENTITY	Hypertonic induction of aquaporin-5 : novel role of hypoxia-inducible_factor-1alpha .
18607959	0	aquaporin-6	37,48	Aqp6	50,54	aquaporin-6	Aqp6	29170(Tax:10116)	29170(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and immunolocalization of aquaporin-6 -LRB- Aqp6 -RRB- in the rat inner ear .
10449905	0	aquaporin-8	75,86	Aqp8	107,111	aquaporin-8	Aqp8	11833(Tax:10090)	11833(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning , structural organization and chromosomal localization of the mouse aquaporin-8 water channel gene -LRB- Aqp8 -RRB- .
20220109	0	aquaporin-9	75,86	AQP9	88,92	aquaporin-9	AQP9	366	366	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	High levels of human chorionic gonadotropin -LRB- hCG -RRB- correlate with increased aquaporin-9 -LRB- AQP9 -RRB- expression in explants from human preeclamptic placenta .
23464865	0	aquaporin-9	19,30	AQP9	32,36	aquaporin-9	AQP9	65054(Tax:10116)	65054(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Changes in retinal aquaporin-9 -LRB- AQP9 -RRB- expression in glaucoma .
16310784	0	aquaporin_0	21,32	m-calpain	36,45	aquaporin 0	m-calpain	4284	824	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of human aquaporin_0 by m-calpain .
18926811	0	aquaporin_1	34,45	AQP1	47,51	aquaporin 1	AQP1	358	358	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and immunodetection of aquaporin_1 -LRB- AQP1 -RRB- in canine spermatozoa .
20149606	0	aquaporin_1	14,25	AQP1	27,31	aquaporin 1	AQP1	358	358	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of aquaporin_1 -LRB- AQP1 -RRB- in human synovitis .
7504987	0	aquaporin_1	33,44	AQP1	46,50	aquaporin 1	AQP1	358	358	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The human gene for water channel aquaporin_1 -LRB- AQP1 -RRB- is localized on chromosome 7p15 -- > p14 .
19776169	0	aquaporin_1	59,70	Angiotensin_II	0,14	aquaporin 1	Angiotensin II	25240(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression modulate|nsubj|END_ENTITY	Angiotensin_II and hypertonicity modulate proximal tubular aquaporin_1 expression .
20663307	0	aquaporin_1	47,58	angiotensin_II	11,25	aquaporin 1	angiotensin II	25240(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of angiotensin_II on the expression of aquaporin_1 in lung of rats following acute_lung_injury -RSB- .
19357255	0	aquaporin_2	20,31	LIP5	0,4	aquaporin 2	LIP5	11827(Tax:10090)	66201(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LIP5 interacts with aquaporin_2 and facilitates its lysosomal degradation .
17056099	0	aquaporin_3	14,25	AQP3	27,31	aquaporin 3	AQP3	360	360	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of aquaporin_3 -LRB- AQP3 -RRB- in normal and neoplastic lung tissues .
22261330	0	aquaporin_3	18,29	c-Met	0,5	aquaporin 3	c-Met	360	4233	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	c-Met upregulates aquaporin_3 expression in human gastric_carcinoma cells via the ERK signalling pathway .
10206998	0	aquaporin_3	66,77	cystic_fibrosis_transmembrane_conductance_regulator	4,55	aquaporin 3	cystic fibrosis transmembrane conductance regulator	360	1080	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The cystic_fibrosis_transmembrane_conductance_regulator activates aquaporin_3 in airway epithelial cells .
17471492	0	aquaporin_3	30,41	insulin	45,52	aquaporin 3	insulin	360	3630	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of aquaporin_3 by insulin .
16246454	0	aquaporin_4	31,42	AQP4	44,48	aquaporin 4	AQP4	421088(Tax:9031)	421088(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Effect of water deprivation on aquaporin_4 -LRB- AQP4 -RRB- mRNA expression in chickens -LRB- Gallus_domesticus -RRB- .
17010308	0	aquaporin_4	73,84	CysLT2	48,54	aquaporin 4	CysLT2	25293(Tax:10116)	170926(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Leukotriene_D4 induces brain_edema and enhances CysLT2 receptor-mediated aquaporin_4 expression .
24893328	0	aquaporin_4	39,50	High-mobility_group_box_1	0,25	aquaporin 4	High-mobility group box 1	25293(Tax:10116)	25459(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	High-mobility_group_box_1 up-regulates aquaporin_4 expression via microglia-astrocyte interaction .
17416972	0	aquaporin_4	18,29	Thrombin	0,8	aquaporin 4	Thrombin	25293(Tax:10116)	29251(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Thrombin inhibits aquaporin_4 expression through protein_kinase_C-dependent pathway in cultured astrocytes .
23469202	0	aquaporin_5	38,49	AQP5	51,55	aquaporin 5	AQP5	11830(Tax:10090)	11830(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hypoxia and hypoxia mimetics decrease aquaporin_5 -LRB- AQP5 -RRB- expression through both hypoxia inducible factor-1a and proteasome-mediated pathways .
21973049	0	aquaporin_5	15,26	TNF-a	0,5	aquaporin 5	TNF-a	362	7124	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TNF-a inhibits aquaporin_5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation .
11279049	0	aquaporin_5	37,48	Tumor_necrosis_factor-alpha	0,27	aquaporin 5	Tumor necrosis factor-alpha	11830(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits aquaporin_5 expression in mouse lung epithelial cells .
25120769	0	aquaporin_8	14,25	Erk1/2	49,55	aquaporin 8	Erk1/2	343	5595;5594	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of aquaporin_8 and phosphorylation of Erk1/2 in cervical epithelial carcinogenesis : correlation with clinicopathological parameters .
21867676	0	aquaporin_9	62,73	AMP-activated_protein_kinase	0,28	aquaporin 9	AMP-activated protein kinase	366	5563	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	AMP-activated_protein_kinase modulates the gene expression of aquaporin_9 via forkhead_box_a2 .
18053968	0	aquaporin_9	19,30	AQP9	32,36	aquaporin 9	AQP9	65054(Tax:10116)	65054(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of brain aquaporin_9 -LRB- AQP9 -RRB- in catecholaminergic neurons in diabetic rats .
18055461	0	aquaporin_9	99,110	NHERF1	8,14	aquaporin 9	NHERF1	366	9368	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of NHERF1 , cystic_fibrosis_transmembrane_conductance_regulator , and cAMP in the regulation of aquaporin_9 .
9524266	0	arabinose_kinase	96,112	ARA1	90,94	arabinose kinase	ARA1	827299(Tax:3702)	827299(Tax:3702)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Analysis of a 14-kb fragment containing a putative cell wall gene and a candidate for the ARA1 , arabinose_kinase , gene from chromosome IV of Arabidopsis_thaliana .
7729529	0	arachidonate_12-lipoxygenase	40,68	Rel	88,91	arachidonate 12-lipoxygenase	Rel	239	5966	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	The transcriptional regulation of human arachidonate_12-lipoxygenase gene by NF_kappa_B / Rel .
26632627	0	arachidonate_5-lipoxygenase	88,115	ALOX5	117,122	arachidonate 5-lipoxygenase	ALOX5	240	240	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Parent-determined oral montelukast therapy for preschool wheeze with stratification for arachidonate_5-lipoxygenase -LRB- ALOX5 -RRB- promoter genotype : a multicentre , randomised , placebo-controlled trial BACKGROUND : The clinical effectiveness of intermittent montelukast for wheeze in young children is unclear .
19126581	0	arachidonate_5-lipoxygenase-activating_protein	16,62	ALOX5AP	64,71	arachidonate 5-lipoxygenase-activating protein	ALOX5AP	241	241	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of the arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and risk of stroke : a HuGE gene-disease association review and meta-analysis .
21199733	0	arachidonate_5-lipoxygenase-activating_protein	12,58	ALOX5AP	60,67	arachidonate 5-lipoxygenase-activating protein	ALOX5AP	241	241	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and risk of coronary_heart_disease : A meta-analysis .
23554707	0	arachidonate_5-lipoxygenase-activating_protein	16,62	ALOX5AP	64,71	arachidonate 5-lipoxygenase-activating protein	ALOX5AP	241	241	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of the arachidonate_5-lipoxygenase-activating_protein -LRB- ALOX5AP -RRB- gene and risk of ischemic_stroke in Han Chinese of eastern China .
17693006	0	aralar	94,100	SLC25A12	84,92	aralar	SLC25A12	8604	8604	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 -LRB- aralar -RRB- gene with schizophrenia .
14525945	0	arginase-1	75,85	GM-CSF	21,27	arginase-1	GM-CSF	383	1437	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Divergent effects of GM-CSF and TGFbeta1 on bone marrow-derived macrophage arginase-1 activity , MCP-1 expression , and matrix_metalloproteinase-12 : a potential role during arteriogenesis .
24833798	0	arginase_2	42,52	histone_deacetylase_2	56,77	arginase 2	histone deacetylase 2	384	3066	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of endothelial arginase_2 by histone_deacetylase_2 .
15922518	0	arginase_I	13,23	IL-4	41,45	arginase I	IL-4	11846(Tax:10090)	16189(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Induction of arginase_I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta .
18828017	0	arginase_I	14,24	PD-1	57,61	arginase I	PD-1	11846(Tax:10090)	18566(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of arginase_I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells .
2675840	0	arginine-vasopressin	37,57	endothelin-1	10,22	arginine-vasopressin	endothelin-1	24221(Tax:10116)	24323(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus .
8910806	0	arginine_vasopressin	81,101	CRH	10,13	arginine vasopressin	CRH	24221(Tax:10116)	81648(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of CRH on the preovulatory LH and FSH surge in the cyclic rat : a role for arginine_vasopressin ?
23877023	0	arginine_vasopressin	73,93	Cyclooxygenase-2	0,16	arginine vasopressin	Cyclooxygenase-2	11998(Tax:10090)	19225(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine_vasopressin .
15671070	0	arginine_vasopressin	66,86	aquaporin-2	28,39	arginine vasopressin	aquaporin-2	11998(Tax:10090)	11827(Tax:10090)	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Hypertonicity regulates the aquaporin-2 promoter independently of arginine_vasopressin .
25016245	0	arginine_vasopressin_receptor_1A	24,56	AVPR1A	58,64	arginine vasopressin receptor 1A	AVPR1A	552	552	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between the arginine_vasopressin_receptor_1A -LRB- AVPR1A -RRB- gene and preschoolers ' executive functioning .
24166829	0	argininosuccinate_lyase	41,64	ASL	66,69	argininosuccinate lyase	ASL	435	435	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations and polymorphisms in the human argininosuccinate_lyase -LRB- ASL -RRB- gene .
19006241	0	argininosuccinate_synthetase	41,69	ASS1	71,75	argininosuccinate synthetase	ASS1	445	445	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations and polymorphisms in the human argininosuccinate_synthetase -LRB- ASS1 -RRB- gene .
15820746	0	argininosuccinate_synthetase	20,48	IL-1beta	0,8	argininosuccinate synthetase	IL-1beta	445	3553	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	IL-1beta stimulates argininosuccinate_synthetase gene expression through NF-kappaB in Caco-2 cells .
22682761	0	argonaute-2	23,34	miR-20a	51,58	argonaute-2	miR-20a	27161	406982	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure of human argonaute-2 in complex with miR-20a .
19458189	0	argonaute_2	32,43	Hsp90	0,5	argonaute 2	Hsp90	27161	3320	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Hsp90 regulates the function of argonaute_2 and its recruitment to stress granules and P-bodies .
25074490	0	aristaless-related_homeobox	70,97	ARX	99,102	aristaless-related homeobox	ARX	170302	170302	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A child with a novel de novo mutation in the aristaless domain of the aristaless-related_homeobox -LRB- ARX -RRB- gene presenting with ambiguous_genitalia and psychomotor delay .
23771350	0	aristaless-related_homeobox	18,45	NLS1	62,66	aristaless-related homeobox	NLS1	170302	84879	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Nuclear import of aristaless-related_homeobox protein via its NLS1 regulates its transcriptional function .
7876319	0	armadillo	32,41	beta-catenin	59,71	armadillo	beta-catenin	31151(Tax:7227)	399274(Tax:8355)	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Embryonic_axis induction by the armadillo repeat domain of beta-catenin : evidence for intracellular signaling .
8937994	0	armadillo	38,47	p0071	63,68	armadillo	p0071	1499	8502	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	Cloning and characterization of a new armadillo family member , p0071 , associated with the junctional plaque : evidence for a subfamily of closely related proteins .
24601692	0	armadillo_repeat_containing_5	56,85	ARMC5	87,92	armadillo repeat containing 5	ARMC5	79798	79798	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Macronodular_adrenal_hyperplasia due to mutations in an armadillo_repeat_containing_5 -LRB- ARMC5 -RRB- gene : a clinical and genetic investigation .
9476900	0	arno	73,77	Sec7	52,56	arno	Sec7	9266	9267	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|domain domain|compound|END_ENTITY	Structure of the guanine_nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase .
17693615	0	aromatase	62,71	cyp19	73,78	aromatase	cyp19	25147(Tax:10116)	25147(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Three promoters PII , PI.f , and PI.tr direct the expression of aromatase -LRB- cyp19 -RRB- gene in male rat germ cells .
22659284	0	aromatase	49,58	cyp19a1	40,47	aromatase	cyp19a1	373656(Tax:8355)	373656(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Brain-specific promoter/exon I.f of the cyp19a1 -LRB- aromatase -RRB- gene in Xenopus_laevis .
17171710	0	aromatic_hydrocarbon_receptor	33,62	AHR	64,67	aromatic hydrocarbon receptor	AHR	714254(Tax:9544)	714254(Tax:9544)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Autoradiographic localization of aromatic_hydrocarbon_receptor -LRB- AHR -RRB- in rhesus_monkey ovary .
18001219	0	aromatic_hydrocarbon_receptor	44,73	Cyclooxygenase-2	0,16	aromatic hydrocarbon receptor	Cyclooxygenase-2	196	5743	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Cyclooxygenase-2 promoter activation by the aromatic_hydrocarbon_receptor in breast_cancer mcf-7 cells : repressive effects of conjugated linoleic_acid .
23690606	0	arrestin	7,15	AP-2	50,54	arrestin	AP-2	20215(Tax:10090)	21418(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina .
7519097	0	arrestin	17,25	Phosrestin_I	0,12	arrestin	Phosrestin I	35078(Tax:7227)	38993(Tax:7227)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	Phosrestin_I , an arrestin homolog that undergoes light-induced phosphorylation in dipteran photoreceptors .
18307387	0	arrestin_domain-containing_4	43,71	ARRDC4	78,84	arrestin domain-containing 4	ARRDC4	91947	91947	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An anomalous haplotype distribution of the arrestin_domain-containing_4 gene -LRB- ARRDC4 -RRB- haplotypes in Caucasians .
25461954	0	arsenite_methyltransferase_gene	38,69	AS3MT	71,76	arsenite methyltransferase gene	AS3MT	57412	57412	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Family-based association study of the arsenite_methyltransferase_gene -LRB- AS3MT , rs11191454 -RRB- in Korean children with attention-deficit_hyperactivity_disorder .
16765900	0	artemin	13,20	GFRalpha3	49,58	artemin	GFRalpha3	9048	2676	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	Structure of artemin complexed with its receptor GFRalpha3 : convergent recognition of glial_cell_line-derived_neurotrophic_factors .
6685642	0	aryl-hydrocarbon_hydroxylase	33,61	AHH	63,66	aryl-hydrocarbon hydroxylase	AHH	1545	1545	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effect of cigarette smoke on aryl-hydrocarbon_hydroxylase -LRB- AHH -RRB- activity of the human kidney .
2295839	0	aryl_hydrocarbon_hydroxylase	36,64	AHH	66,69	aryl hydrocarbon hydroxylase	AHH	24296(Tax:10116)	24296(Tax:10116)	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of cytochrome_P-450-mediated aryl_hydrocarbon_hydroxylase -LRB- AHH -RRB- are higher in differentiated than in germinative cutaneous keratinocytes .
3619494	0	aryl_hydrocarbon_hydroxylase	66,94	AHH	96,99	aryl hydrocarbon hydroxylase	AHH	1545	1545	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of exposure to air pollution and smoking on the placental aryl_hydrocarbon_hydroxylase -LRB- AHH -RRB- activity .
6944164	0	aryl_hydrocarbon_hydroxylase	16,44	AHH	46,49	aryl hydrocarbon hydroxylase	AHH	1545	1545	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A twin study of aryl_hydrocarbon_hydroxylase -LRB- AHH -RRB- inducibility in cultured lymphocytes .
2154949	0	aryl_hydrocarbon_hydroxylase	46,74	Ah_receptor	24,35	aryl hydrocarbon hydroxylase	Ah receptor	1544	196	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|mediating mediating|compound|END_ENTITY	Characterization of the Ah_receptor mediating aryl_hydrocarbon_hydroxylase induction in the human liver cell line Hep G2 .
2545344	0	aryl_hydrocarbon_hydroxylase	33,61	Ah_receptor	124,135	aryl hydrocarbon hydroxylase	Ah receptor	1551	196	Gene	Gene	lines|amod|START_ENTITY induction|nmod|lines induction|nmod|END_ENTITY	Structure-dependent induction of aryl_hydrocarbon_hydroxylase in human breast_cancer cell lines and characterization of the Ah_receptor .
3011254	0	aryl_hydrocarbon_hydroxylase	35,63	Ah_receptor	0,11	aryl hydrocarbon hydroxylase	Ah receptor	1544	196	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Ah_receptor mediating induction of aryl_hydrocarbon_hydroxylase : detection in human lung by binding of 2,3,7,8 - -LSB- 3H -RSB- tetrachlorodibenzo-p-dioxin .
9731718	0	aryl_hydrocarbon_hydroxylase	32,60	CYP1A1	25,31	aryl hydrocarbon hydroxylase	CYP1A1	1543	1543	Gene	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	The relationship between CYP1A1 aryl_hydrocarbon_hydroxylase activity and lung_cancer in a Japanese population .
22761424	0	aryl_hydrocarbon_receptor	134,159	ABCB6	115,120	aryl hydrocarbon receptor	ABCB6	11622(Tax:10090)	74104(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Polycyclic_aromatic_hydrocarbons -LRB- PAHs -RRB- mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl_hydrocarbon_receptor -LRB- AhR -RRB- .
19380484	0	aryl_hydrocarbon_receptor	25,50	AHR	52,55	aryl hydrocarbon receptor	AHR	196	196	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	The active form of human aryl_hydrocarbon_receptor -LRB- AHR -RRB- repressor lacks exon 8 , and its Pro 185 and Ala 185 variants repress both AHR and hypoxia-inducible_factor .
22211302	0	aryl_hydrocarbon_receptor	51,76	AHR	78,81	aryl hydrocarbon receptor	AHR	196	196	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The association of functional polymorphisms in the aryl_hydrocarbon_receptor -LRB- AHR -RRB- gene with the risk of vitiligo in Han Chinese populations .
22628113	0	aryl_hydrocarbon_receptor	25,50	AHR	52,55	aryl hydrocarbon receptor	AHR	196	196	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The evolving role of the aryl_hydrocarbon_receptor -LRB- AHR -RRB- in the normophysiology of hematopoiesis .
18000031	0	aryl_hydrocarbon_receptor	14,39	AHR_repressor	59,72	aryl hydrocarbon receptor	AHR repressor	196	57491	Gene	Gene	START_ENTITY|dep|signaling signaling|nmod|END_ENTITY	Repression of aryl_hydrocarbon_receptor -LRB- AHR -RRB- signaling by AHR_repressor : role of DNA binding and competition for AHR nuclear translocator .
24136190	0	aryl_hydrocarbon_receptor	45,70	ARNT	71,75	aryl hydrocarbon receptor	ARNT	100192396(Tax:10141)	100379223(Tax:10141)	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Nucleotide specificity of DNA binding of the aryl_hydrocarbon_receptor : ARNT complex is unaffected by ligand structure .
24330582	0	aryl_hydrocarbon_receptor	3,28	ATF4	61,65	aryl hydrocarbon receptor	ATF4	196	468	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	An aryl_hydrocarbon_receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 .
21616089	0	aryl_hydrocarbon_receptor	4,29	ATP5a1	45,51	aryl hydrocarbon receptor	ATP5a1	11622(Tax:10090)	11946(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The aryl_hydrocarbon_receptor interacts with ATP5a1 , a subunit of the ATP synthase complex , and modulates mitochondrial function .
10722677	0	aryl_hydrocarbon_receptor	59,84	AhR	86,89	aryl hydrocarbon receptor	AhR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- by the ubiquitin-proteasome pathway .
10961990	0	aryl_hydrocarbon_receptor	11,36	AhR	38,41	aryl hydrocarbon receptor	AhR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of aryl_hydrocarbon_receptor -LRB- AhR -RRB- to AhR-interacting_protein .
12490139	0	aryl_hydrocarbon_receptor	26,51	AhR	123,126	aryl hydrocarbon receptor	AhR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
12520072	0	aryl_hydrocarbon_receptor	39,64	AhR	66,69	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation between gene expression of aryl_hydrocarbon_receptor -LRB- AhR -RRB- , hydrocarbon receptor nuclear translocator -LRB- Arnt -RRB- , cytochromes P4501A1 -LRB- CYP1A1 -RRB- and 1B1 -LRB- CYP1B1 -RRB- , and inducibility of CYP1A1 and CYP1B1 in human lymphocytes .
18378297	0	aryl_hydrocarbon_receptor	33,58	AhR	60,63	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Estrogenic effect of dioxin-like aryl_hydrocarbon_receptor -LRB- AhR -RRB- agonist -LRB- PCB congener 126 -RRB- in salmon hepatocytes .
21627536	0	aryl_hydrocarbon_receptor	10,35	AhR	37,40	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of aryl_hydrocarbon_receptor -LRB- AhR -RRB- knockdown on cell cycle progression in human HaCaT keratinocytes .
21858153	0	aryl_hydrocarbon_receptor	14,39	AhR	41,44	aryl hydrocarbon receptor	AhR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis .
23963493	0	aryl_hydrocarbon_receptor	12,37	AhR	39,42	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- in lung_inflammation .
24565903	0	aryl_hydrocarbon_receptor	29,54	AhR	56,59	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	IL-1 and TNF-a regulation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in HSY human salivary cells .
25316167	0	aryl_hydrocarbon_receptor	37,62	AhR	64,67	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	DDE and PCB_153 independently induce aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in peripheral blood mononuclear cells .
25349783	0	aryl_hydrocarbon_receptor	32,57	AhR	59,62	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	The activation mechanism of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- by molecular chaperone HSP90 .
25797602	0	aryl_hydrocarbon_receptor	48,73	AhR	75,78	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	pathway|compound|START_ENTITY pathway|appos|END_ENTITY	TCDD and omeprazole prime platelets through the aryl_hydrocarbon_receptor -LRB- AhR -RRB- non-genomic pathway .
26219504	0	aryl_hydrocarbon_receptor	50,75	AhR	88,91	aryl hydrocarbon receptor	AhR	25690(Tax:10116)	25690(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Hexachlorobenzene induces cell proliferation , and aryl_hydrocarbon_receptor expression -LRB- AhR -RRB- in rat liver preneoplastic foci , and in the human hepatoma cell line HepG2 .
26219504	0	aryl_hydrocarbon_receptor	50,75	AhR	88,91	aryl hydrocarbon receptor	AhR	25690(Tax:10116)	25690(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Hexachlorobenzene induces cell proliferation , and aryl_hydrocarbon_receptor expression -LRB- AhR -RRB- in rat liver preneoplastic foci , and in the human hepatoma cell line HepG2 .
26513682	0	aryl_hydrocarbon_receptor	12,37	AhR	39,42	aryl hydrocarbon receptor	AhR	196	196	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of aryl_hydrocarbon_receptor -LRB- AhR -RRB- in the pathology of pleomorphic_adenoma in parotid gland .
20478695	0	aryl_hydrocarbon_receptor	68,93	B_lymphocyte-induced_maturation_protein_1	0,41	aryl hydrocarbon receptor	B lymphocyte-induced maturation protein 1	11622(Tax:10090)	12142(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	B_lymphocyte-induced_maturation_protein_1 is a novel target gene of aryl_hydrocarbon_receptor .
24519489	0	aryl_hydrocarbon_receptor	34,59	CD11c	79,84	aryl hydrocarbon receptor	CD11c	196	3687	Gene	Gene	START_ENTITY|nmod|function function|nmod|cells cells|amod|END_ENTITY	New insights into the role of the aryl_hydrocarbon_receptor in the function of CD11c cells during respiratory viral infection .
27068235	0	aryl_hydrocarbon_receptor	13,38	CD11c	48,53	aryl hydrocarbon receptor	CD11c	11622(Tax:10090)	16411(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Ablating the aryl_hydrocarbon_receptor -LRB- AhR -RRB- in CD11c + cells perturbs intestinal epithelium development and intestinal immunity .
16177056	0	aryl_hydrocarbon_receptor	32,57	CD25	128,132	aryl hydrocarbon receptor	CD25	11622(Tax:10090)	16184(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY generates|nsubj|activation generates|dobj|population population|nmod|cells cells|compound|END_ENTITY	Cutting edge : activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4 + CD25 + cells with characteristics of regulatory T cells .
10886394	0	aryl_hydrocarbon_receptor	139,164	CD4	41,44	aryl hydrocarbon receptor	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY cells|nmod|activation Generation|dep|cells Generation|nmod|END_ENTITY	Generation of alphabeta T-cell receptor + CD4 - CD8 + cells in major histocompatibility complex class I-deficient mice upon activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
12490139	0	aryl_hydrocarbon_receptor	26,51	CD4	146,149	aryl hydrocarbon receptor	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|+ +|compound|END_ENTITY	T lymphocytes are direct , aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- : AhR expression in both CD4 + and CD8 + T cells is necessary for full suppression of a cytotoxic T lymphocyte response by TCDD .
16177056	0	aryl_hydrocarbon_receptor	32,57	CD4	123,126	aryl hydrocarbon receptor	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY generates|nsubj|activation generates|dobj|population population|nmod|cells cells|compound|END_ENTITY	Cutting edge : activation of the aryl_hydrocarbon_receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4 + CD25 + cells with characteristics of regulatory T cells .
18382861	0	aryl_hydrocarbon_receptor	165,190	CD4	194,197	aryl hydrocarbon receptor	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation of alloreactive CD8 + T cells toward a regulatory T cell phenotype by a mechanism that is dependent on aryl_hydrocarbon_receptor in CD4 + T cells .
20231432	0	aryl_hydrocarbon_receptor	74,99	CD4	42,45	aryl hydrocarbon receptor	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	stimulating|dobj|START_ENTITY drives|advcl|stimulating drives|dobj|secretion secretion|nmod|cells cells|compound|END_ENTITY	Notch signaling drives IL-22 secretion in CD4 + T cells by stimulating the aryl_hydrocarbon_receptor .
21525997	0	aryl_hydrocarbon_receptor	76,101	CD4	57,60	aryl hydrocarbon receptor	CD4	196	920	Gene	Gene	cells|nmod|START_ENTITY favors|nsubj|cells favors|nmod|T T|compound|END_ENTITY	In vivo dioxin favors interleukin-22 production by human CD4 + T cells in an aryl_hydrocarbon_receptor -LRB- AhR -RRB- - dependent manner .
22609446	0	aryl_hydrocarbon_receptor	4,29	CD4	91,94	aryl hydrocarbon receptor	CD4	196	920	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|acts acts|nmod|monocytes monocytes|acl|ve ve|dobj|cells cells|amod|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AhR -RRB- ligand VAF347 selectively acts on monocytes and na ve CD4 -LRB- + -RRB- Th cells to promote the development of IL-22-secreting Th cells .
26071552	0	aryl_hydrocarbon_receptor	18,43	CD4	86,89	aryl hydrocarbon receptor	CD4	11622(Tax:10090)	12504(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY enhances|nsubj|Activation enhances|dobj|response response|compound|END_ENTITY	Activation of the aryl_hydrocarbon_receptor during development enhances the pulmonary CD4 + T cell response to viral_infection .
11959854	0	aryl_hydrocarbon_receptor	73,98	CYP1A1	29,35	aryl hydrocarbon receptor	CYP1A1	196	1543	Gene	Gene	START_ENTITY|nsubj|induction induction|nmod|END_ENTITY	Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl_hydrocarbon_receptor - and calcium-dependent .
16109480	0	aryl_hydrocarbon_receptor	40,65	CYP3A4	8,14	aryl hydrocarbon receptor	CYP3A4	196	1576	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of CYP3A4 in the regulation of the aryl_hydrocarbon_receptor by omeprazole_sulphide .
17481570	0	aryl_hydrocarbon_receptor	76,101	Cytochrome_P450	0,15	aryl hydrocarbon receptor	Cytochrome P450	11622(Tax:10090)	13079(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|regulation regulation|amod|END_ENTITY	Cytochrome_P450 gene regulation and physiological functions mediated by the aryl_hydrocarbon_receptor .
18524851	0	aryl_hydrocarbon_receptor	4,29	E2F1	39,43	aryl hydrocarbon receptor	E2F1	196	1869	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The aryl_hydrocarbon_receptor binds to E2F1 and inhibits E2F1-induced apoptosis .
22116805	0	aryl_hydrocarbon_receptor	4,29	Fshr	46,50	aryl hydrocarbon receptor	Fshr	11622(Tax:10090)	14309(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The aryl_hydrocarbon_receptor regulates mouse Fshr promoter activity through an e-box binding site .
25349783	0	aryl_hydrocarbon_receptor	32,57	HSP90	87,92	aryl hydrocarbon receptor	HSP90	196	3320	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The activation mechanism of the aryl_hydrocarbon_receptor -LRB- AhR -RRB- by molecular chaperone HSP90 .
24565903	0	aryl_hydrocarbon_receptor	29,54	IL-1	0,4	aryl hydrocarbon receptor	IL-1	196	3553	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	IL-1 and TNF-a regulation of aryl_hydrocarbon_receptor -LRB- AhR -RRB- expression in HSY human salivary cells .
24403534	0	aryl_hydrocarbon_receptor	4,29	IL-10	39,44	aryl hydrocarbon receptor	IL-10	11622(Tax:10090)	16153(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	The aryl_hydrocarbon_receptor promotes IL-10 production by NK cells .
24380854	0	aryl_hydrocarbon_receptor	43,68	Insulin_like_growth_factor_2	0,28	aryl hydrocarbon receptor	Insulin like growth factor 2	196	3481	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Insulin_like_growth_factor_2 regulation of aryl_hydrocarbon_receptor in MCF-7 breast_cancer cells .
22615911	0	aryl_hydrocarbon_receptor	90,115	PEPCK	65,70	aryl hydrocarbon receptor	PEPCK	11622(Tax:10090)	18534(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	PCB_126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl_hydrocarbon_receptor .
8824276	0	aryl_hydrocarbon_receptor	64,89	Protein_kinase_C	0,16	aryl hydrocarbon receptor	Protein kinase C	196	112476	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Protein_kinase_C modulates regulation of the CYP1A1 gene by the aryl_hydrocarbon_receptor .
19768455	0	aryl_hydrocarbon_receptor	127,152	R-spondin1	101,111	aryl hydrocarbon receptor	R-spondin1	196	284654	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Inhibitory effects of cigarette_smoke_extract on neural crest migration occur through suppression of R-spondin1 expression via aryl_hydrocarbon_receptor .
25305016	0	aryl_hydrocarbon_receptor	113,138	SIN3A	0,5	aryl hydrocarbon receptor	SIN3A	196	25942	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	SIN3A , generally regarded as a transcriptional repressor , is required for induction of gene transcription by the aryl_hydrocarbon_receptor .
11368516	0	aryl_hydrocarbon_receptor	97,122	Short_heterodimer_partner	0,25	aryl hydrocarbon receptor	Short heterodimer partner	196	8431	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Short_heterodimer_partner -LRB- SHP -RRB- orphan nuclear receptor inhibits the transcriptional activity of aryl_hydrocarbon_receptor -LRB- AHR -RRB- / AHR nuclear translocator -LRB- ARNT -RRB- .
16952353	0	aryl_hydrocarbon_receptor	64,89	Slug	33,37	aryl hydrocarbon receptor	Slug	196	6591	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Zinc finger transcription factor Slug is a novel target gene of aryl_hydrocarbon_receptor .
27060206	0	aryl_hydrocarbon_receptor	19,44	Smad4	98,103	aryl hydrocarbon receptor	Smad4	196	4089	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|degradation degradation|nmod|END_ENTITY	Ligand independent aryl_hydrocarbon_receptor inhibits lung_cancer cell invasion by degradation of Smad4 .
9405238	0	aryl_hydrocarbon_receptor	64,89	Transforming_growth_factor-beta1	0,32	aryl hydrocarbon receptor	Transforming growth factor-beta1	196	7040	Gene	Gene	expression|nmod|START_ENTITY coregulates|dobj|expression coregulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 coregulates mRNA expression of aryl_hydrocarbon_receptor and cell-cycle-regulating genes in human cancer cell lines .
17557910	0	aryl_hydrocarbon_receptor	49,74	Tumor_necrosis_factor-alpha	0,27	aryl hydrocarbon receptor	Tumor necrosis factor-alpha	25690(Tax:10116)	24835(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Tumor_necrosis_factor-alpha modulates effects of aryl_hydrocarbon_receptor ligands on cell proliferation and expression of cytochrome_P450 enzymes in rat liver `` stem-like '' cells .
18359762	0	aryl_hydrocarbon_receptor	4,29	VEGF	98,102	aryl hydrocarbon receptor	VEGF	11622(Tax:10090)	22339(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|production production|nsubj|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	The aryl_hydrocarbon_receptor -LRB- AhR -RRB- inhibits vanadate-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- production in TRAMP prostates .
24330582	0	aryl_hydrocarbon_receptor	3,28	VEGF	37,41	aryl hydrocarbon receptor	VEGF	196	7422	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	An aryl_hydrocarbon_receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2 .
22727790	0	aryl_hydrocarbon_receptor	45,70	apolipoprotein_A-I	14,32	aryl hydrocarbon receptor	apolipoprotein A-I	196	335	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Inhibition of apolipoprotein_A-I gene by the aryl_hydrocarbon_receptor : a potential mechanism for smoking-associated hypoalphalipoproteinemia .
20140206	0	aryl_hydrocarbon_receptor	81,106	beta-TrCP	0,9	aryl hydrocarbon receptor	beta-TrCP	196	8945	Gene	Gene	growth|nmod|START_ENTITY growth|amod|END_ENTITY	beta-TrCP inhibition reduces_prostate_cancer cell growth via upregulation of the aryl_hydrocarbon_receptor .
20676095	0	aryl_hydrocarbon_receptor	4,29	c-Maf	45,50	aryl hydrocarbon receptor	c-Maf	196	4094	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The aryl_hydrocarbon_receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 .
16091746	0	aryl_hydrocarbon_receptor	4,29	c-myc	55,60	aryl hydrocarbon receptor	c-myc	196	4609	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	The aryl_hydrocarbon_receptor constitutively represses c-myc transcription in human mammary_tumor cells .
15930751	0	aryl_hydrocarbon_receptor	55,80	carbonic_anhydrase_III	15,37	aryl hydrocarbon receptor	carbonic anhydrase III	25690(Tax:10116)	54232(Tax:10116)	Gene	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	Suppression of carbonic_anhydrase_III mRNA level by an aryl_hydrocarbon_receptor ligand in primary cultured hepatocytes of rat .
16192470	0	aryl_hydrocarbon_receptor	4,29	epiregulin	82,92	aryl hydrocarbon receptor	epiregulin	25690(Tax:10116)	59325(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The aryl_hydrocarbon_receptor directly regulates expression of the potent mitogen epiregulin .
26068716	0	aryl_hydrocarbon_receptor	63,88	fetuin-A	35,43	aryl hydrocarbon receptor	fetuin-A	196	197	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Indoxyl_sulfate suppresses hepatic fetuin-A expression via the aryl_hydrocarbon_receptor in HepG2 cells .
18827440	0	aryl_hydrocarbon_receptor	89,114	insulin-like_growth_factor_binding_protein-1	14,58	aryl hydrocarbon receptor	insulin-like growth factor binding protein-1	11622(Tax:10090)	16006(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of insulin-like_growth_factor_binding_protein-1 and lipoprotein_lipase by the aryl_hydrocarbon_receptor .
23973224	0	aryl_hydrocarbon_receptor	46,71	interleukin-22	107,121	aryl hydrocarbon receptor	interleukin-22	196	50616	Gene	Gene	reactivity|compound|START_ENTITY reactivity|nmod|END_ENTITY	Tryptophan catabolites from microbiota engage aryl_hydrocarbon_receptor and balance mucosal reactivity via interleukin-22 .
22037483	0	aryl_hydrocarbon_receptor	43,68	osteopontin	17,28	aryl hydrocarbon receptor	osteopontin	196	6696	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of osteopontin expression by aryl_hydrocarbon_receptor via both ligand-dependent and ligand-independent pathways in lung_cancer .
9765510	0	aryl_hydrocarbon_receptor	4,29	transcription_factor_IIB	45,69	aryl hydrocarbon receptor	transcription factor IIB	196	29105	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The aryl_hydrocarbon_receptor interacts with transcription_factor_IIB .
9145908	0	aryl_hydrocarbon_receptor	60,85	transforming_growth_factor-beta1	10,42	aryl hydrocarbon receptor	transforming growth factor-beta1	196	7040	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of transforming_growth_factor-beta1 on expression of aryl_hydrocarbon_receptor and genes of Ah gene battery : clues for independent down-regulation in A549 cells .
24366639	0	aryl_hydrocarbon_receptor-interacting_protein	9,54	AIP	4,7	aryl hydrocarbon receptor-interacting protein	AIP	9049	9049	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The AIP -LRB- aryl_hydrocarbon_receptor-interacting_protein -RRB- gene and its relation to the pathogenesis of pituitary_adenomas .
24996936	0	aryl_hydrocarbon_receptor-interacting_protein	33,78	AIP	80,83	aryl hydrocarbon receptor-interacting protein	AIP	9049	9049	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel germline mutation in the aryl_hydrocarbon_receptor-interacting_protein -LRB- AIP -RRB- gene in an Italian family with gigantism .
25614825	0	aryl_hydrocarbon_receptor-interacting_protein	81,126	AIP	128,131	aryl hydrocarbon receptor-interacting protein	AIP	9049	9049	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An unusual case of an ACTH-secreting macroadenoma with a germline variant in the aryl_hydrocarbon_receptor-interacting_protein -LRB- AIP -RRB- gene .
17242703	0	aryl_hydrocarbon_receptor_interacting_protein	21,66	AIP	68,71	aryl hydrocarbon receptor interacting protein	AIP	9049	9049	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of aryl_hydrocarbon_receptor_interacting_protein -LRB- AIP -RRB- gene in colorectal , breast , _ and_prostate_cancers .
20506337	0	aryl_hydrocarbon_receptor_interacting_protein	20,65	AIP	67,70	aryl hydrocarbon receptor interacting protein	AIP	9049	9049	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of aryl_hydrocarbon_receptor_interacting_protein -LRB- AIP -RRB- mutations in familial isolated pituitary_adenoma families .
10721670	0	aryl_hydrocarbon_receptor_nuclear_translocator	6,52	ARNT	59,63	aryl hydrocarbon receptor nuclear translocator	ARNT	405	405	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human aryl_hydrocarbon_receptor_nuclear_translocator gene -LRB- ARNT -RRB- D/N511 polymorphism .
11074397	0	aryl_hydrocarbon_receptor_nuclear_translocator	47,93	ARNT	95,99	aryl hydrocarbon receptor nuclear translocator	ARNT	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Expression and subcellular localization of the aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- protein in mouse and chicken over developmental time .
14961334	0	aryl_hydrocarbon_receptor_nuclear_translocator	14,60	ARNT	62,66	aryl hydrocarbon receptor nuclear translocator	ARNT	100136759(Tax:8022)	100136759(Tax:8022)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- isoforms in juvenile and adult rainbow_trout tissues .
8662957	0	aryl_hydrocarbon_receptor_nuclear_translocator	16,62	ARNT	64,68	aryl hydrocarbon receptor nuclear translocator	ARNT	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the aryl_hydrocarbon_receptor_nuclear_translocator -LRB- ARNT -RRB- in hypoxic induction of gene expression .
11043581	0	aryl_hydrocarbon_receptor_nuclear_translocator	30,76	Arnt	78,82	aryl hydrocarbon receptor nuclear translocator	Arnt	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Conditional disruption of the aryl_hydrocarbon_receptor_nuclear_translocator -LRB- Arnt -RRB- gene leads to loss of target gene induction by the aryl_hydrocarbon_receptor and hypoxia-inducible factor 1alpha .
11230806	0	aryl_hydrocarbon_receptor_nuclear_translocator	78,124	rtARNT	126,132	aryl hydrocarbon receptor nuclear translocator	rtARNT	100136759(Tax:8022)	100136759(Tax:8022)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Functional analysis of activation and repression domains of the rainbow_trout aryl_hydrocarbon_receptor_nuclear_translocator -LRB- rtARNT -RRB- protein isoforms .
9722945	0	aryl_hydrocarbon_receptor_nuclear_translocator-2	35,83	Arnt2	85,90	aryl hydrocarbon receptor nuclear translocator-2	Arnt2	11864(Tax:10090)	11864(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Physical localization of the mouse aryl_hydrocarbon_receptor_nuclear_translocator-2 -LRB- Arnt2 -RRB- gene within the c112K deletion .
16755028	0	aryl_hydrocarbon_receptor_repressor	25,60	AhRR	62,66	aryl hydrocarbon receptor repressor	AhRR	57491	57491	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The inhibitory effect of aryl_hydrocarbon_receptor_repressor -LRB- AhRR -RRB- on the growth of human breast_cancer MCF-7 cells .
18565642	0	aryl_hydrocarbon_receptor_repressor	22,57	estrogen_receptor_alpha	89,112	aryl hydrocarbon receptor repressor	estrogen receptor alpha	57491	2099	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Suppressive effect of aryl_hydrocarbon_receptor_repressor on transcriptional activity of estrogen_receptor_alpha by protein-protein interaction in stably and transiently expressing cell lines .
25718343	1	aryl_hydrocarbon_receptors	20,46	AHR	48,51	aryl hydrocarbon receptors	AHR	196	196	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of aryl_hydrocarbon_receptors -LRB- AHR -RRB- in the condition of experimental acute ileitis and administrations simvastatin and antagonist of receptors in interlekin-1 .
15332344	0	arylalkylamine-N-acetyl-transferase	23,58	AA-NAT	60,66	arylalkylamine-N-acetyl-transferase	AA-NAT	15	15	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variability of arylalkylamine-N-acetyl-transferase -LRB- AA-NAT -RRB- gene and human sleep/wake pattern .
23284853	0	arylalkylamine-N-acetyltransferase	102,136	AA-NAT	138,144	arylalkylamine-N-acetyltransferase	AA-NAT	11298(Tax:10090)	11298(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	NF-kB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase -LRB- AA-NAT -RRB- gene .
12736803	0	arylalkylamine_N-acetyltransferase	31,65	AA-NAT	68,74	arylalkylamine N-acetyltransferase	AA-NAT	15	15	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Significant association of the arylalkylamine_N-acetyltransferase -LRB- AA-NAT -RRB- gene with delayed_sleep_phase_syndrome .
17877143	0	arylalkylamine_N-acetyltransferase	40,74	AA-NAT	76,82	arylalkylamine N-acetyltransferase	AA-NAT	15	15	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	In vitro effects of steroid hormones on arylalkylamine_N-acetyltransferase -LRB- AA-NAT -RRB- activity in the pineal of fish , Clarias gariepinus -LRB- Burchell , 1822 -RRB- during different phases of breeding cycle .
21341536	0	arylalkylamine_N-acetyltransferase	68,102	AA-NAT	104,110	arylalkylamine N-acetyltransferase	AA-NAT	15	15	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	In vitro effects of 5-hydroxytryptophan , indoleamines and leptin on arylalkylamine_N-acetyltransferase -LRB- AA-NAT -RRB- activity in pineal organ of the fish , Clarias gariepinus -LRB- Burchell , 1822 -RRB- during different phases of the breeding cycle .
11985883	0	arylalkylamine_N-acetyltransferase	23,57	AANAT	59,64	arylalkylamine N-acetyltransferase	AANAT	25120(Tax:10116)	25120(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Neuronal expression of arylalkylamine_N-acetyltransferase -LRB- AANAT -RRB- mRNA in the rat brain .
16687311	0	arylalkylamine_N-acetyltransferase	14,48	AANAT	50,55	arylalkylamine N-acetyltransferase	AANAT	15	15	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of arylalkylamine_N-acetyltransferase -LRB- AANAT -RRB- in the retina .
20459461	0	arylalkylamine_N-acetyltransferase	41,75	AANAT	77,82	arylalkylamine N-acetyltransferase	AANAT	15	15	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Resequencing and association analysis of arylalkylamine_N-acetyltransferase -LRB- AANAT -RRB- gene and its contribution to major_depression susceptibility .
17292900	0	arylalkylamine_N-acetyltransferase	13,47	AANAT2	49,55	arylalkylamine N-acetyltransferase	AANAT2	100135881(Tax:8022)	100135881(Tax:8022)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Evidence for arylalkylamine_N-acetyltransferase -LRB- AANAT2 -RRB- expression in rainbow_trout peripheral tissues with emphasis in the gastrointestinal tract .
15522812	0	arylalkylamine_N-acetyltransferase	116,150	Aanat	152,157	arylalkylamine N-acetyltransferase	Aanat	15	15	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Convergent evolution of strigiform and caprimulgiform dark-activity is supported by phylogenetic analysis using the arylalkylamine_N-acetyltransferase -LRB- Aanat -RRB- gene .
25908644	0	arylhydrocarbon-receptor	70,94	androgen_receptor	108,125	arylhydrocarbon-receptor	androgen receptor	196	367	Gene	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	A novel prostate_cancer therapeutic strategy using icaritin-activated arylhydrocarbon-receptor to co-target androgen_receptor and its splice variants .
98133	0	arylhydrocarbon_hydroxylase	13,40	PCB	77,80	arylhydrocarbon hydroxylase	PCB	1545	5091	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of arylhydrocarbon_hydroxylase and UDP_glucuronosyl_transferase by PCB in hepatic cell cultures .
11681798	0	arylhydrocarbon_receptor	20,44	AhR	46,49	arylhydrocarbon receptor	AhR	100008995(Tax:9986)	100008995(Tax:9986)	Gene	Gene	control|nmod|START_ENTITY control|appos|END_ENTITY	Hormonal control of arylhydrocarbon_receptor -LRB- AhR -RRB- expression in the preimplantation rabbit uterus .
12738279	0	arylhydrocarbon_receptor	25,49	AhR	51,54	arylhydrocarbon receptor	AhR	11622(Tax:10090)	11622(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Functional activation of arylhydrocarbon_receptor -LRB- AhR -RRB- in primary T cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin .
11595506	0	arylhydrocarbon_receptor	18,42	steroidogenic_acute_regulatory	56,86	arylhydrocarbon receptor	steroidogenic acute regulatory	196	6770	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|amod|END_ENTITY	The effect of the arylhydrocarbon_receptor on the human steroidogenic_acute_regulatory gene promoter activity .
14530333	0	arylhydrocarbon_receptor_nuclear_translocator	30,75	Arnt	77,81	arylhydrocarbon receptor nuclear translocator	Arnt	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	T cell-specific disruption of arylhydrocarbon_receptor_nuclear_translocator -LRB- Arnt -RRB- gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution .
15302609	0	arylsulfatase-A	119,134	interleukin-8	61,74	arylsulfatase-A	interleukin-8	410	3576	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Determination of diagnostic and prognostic values of urinary interleukin-8 , tumor_necrosis_factor-alpha , and leukocyte arylsulfatase-A activity in patients with bladder_cancer .
15302609	0	arylsulfatase-A	119,134	tumor_necrosis_factor-alpha	76,103	arylsulfatase-A	tumor necrosis factor-alpha	410	7124	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Determination of diagnostic and prognostic values of urinary interleukin-8 , tumor_necrosis_factor-alpha , and leukocyte arylsulfatase-A activity in patients with bladder_cancer .
27985	0	arylsulfatase_A	12,27	ARS_A	29,34	arylsulfatase A	ARS A	410	410	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of arylsulfatase_A -LRB- ARS_A -RRB- in multiple sulfatase deficiency_disorder_fibroblasts .
6136972	0	arylsulfatase_A	72,87	cerebroside_sulfatase	89,110	arylsulfatase A	cerebroside sulfatase	410	410	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Juvenile and adult metachromatic_leukodystrophy : partial restoration of arylsulfatase_A -LRB- cerebroside_sulfatase -RRB- activity by inhibitors of thiol proteinases .
25511584	0	arylsulfatase_B	88,103	BMP4	107,111	arylsulfatase B	BMP4	411	652	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
19346317	0	arylsulfatase_B	62,77	IL-8	11,15	arylsulfatase B	IL-8	411	3576	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase_B silencing due to sequestration with chondroitin-4-sulfate .
23385884	0	arylsulfatase_B	62,77	N-acetylgalactosamine-4-sulfatase	27,60	arylsulfatase B	N-acetylgalactosamine-4-sulfatase	25227(Tax:10116)	25227(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|nummod|END_ENTITY	Impact of salt exposure on N-acetylgalactosamine-4-sulfatase -LRB- arylsulfatase_B -RRB- activity , glycosaminoglycans , kininogen , and bradykinin .
25511584	0	arylsulfatase_B	88,103	chondroitin-4-sulfotransferase	14,44	arylsulfatase B	chondroitin-4-sulfotransferase	411	50515	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
25825126	0	arylsulfatase_G	37,52	ARSG	54,58	arylsulfatase G	ARSG	22901	22901	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Accumulation of rare variants in the arylsulfatase_G -LRB- ARSG -RRB- gene in task-specific dystonia .
19262745	0	arylsulfatase_I	24,39	ARSI	41,45	arylsulfatase I	ARSI	340075	340075	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the arylsulfatase_I -LRB- ARSI -RRB- gene preferentially expressed in the human retinal pigment epithelium cell line ARPE-19 .
26609033	0	arylsulphatase_B	23,39	ARSB	41,45	arylsulphatase B	ARSB	411	411	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations of the arylsulphatase_B -LRB- ARSB -RRB- gene in Indian patients with mucopolysaccharidosis_type_VI .
18855599	0	asialoglycoprotein_receptor	43,70	ASGPR	72,77	asialoglycoprotein receptor	ASGPR	432	432	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Targeted delivery of macromolecular drugs : asialoglycoprotein_receptor -LRB- ASGPR -RRB- expression by selected hepatoma cell lines used in antiviral drug development .
20561401	0	asparagine_synthetase	22,43	L-asparaginase	85,99	asparagine synthetase	L-asparaginase	440	80150	Gene	Gene	level|amod|START_ENTITY level|nmod|END_ENTITY	-LSB- Relationship between asparagine_synthetase expression level and cell sensitivity to L-asparaginase in human leukemic cell lines -RSB- .
12887345	0	aspartate_aminotransferase	10,36	AST	38,41	aspartate aminotransferase	AST	26503	26503	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of aspartate_aminotransferase -LRB- AST -RRB- in saliva of patients with different periodontal conditions .
15899678	0	aspartate_aminotransferase	41,67	AST	69,72	aspartate aminotransferase	AST	26503	26503	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	A reference material for traceability of aspartate_aminotransferase -LRB- AST -RRB- results .
6426132	0	aspartate_aminotransferase	18,44	AST	46,49	aspartate aminotransferase	AST	26503	26503	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Relation between aspartate_aminotransferase -LRB- AST -RRB- activity in the seminal fluid and indicators of boar ejaculate quality -RSB- .
16634055	0	aspartoacylase	15,29	BDNF	47,51	aspartoacylase	BDNF	79251(Tax:10116)	24225(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis .
25024137	0	aspartoacylase	16,30	Gata6	0,5	aspartoacylase	Gata6	11484(Tax:10090)	14465(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival .
22041583	0	astrocyte-elevated_gene-1	40,65	AEG-1	67,72	astrocyte-elevated gene-1	AEG-1	92140	92140	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Exposure to cadmium_chloride influences astrocyte-elevated_gene-1 -LRB- AEG-1 -RRB- expression in MDA-MB231 human breast_cancer cells .
24989027	0	astrocyte_elevated_gene-1	14,39	AEG-1	41,46	astrocyte elevated gene-1	AEG-1	92140	92140	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- as a biomarker for aggressive pancreatic_ductal_adenocarcinoma .
25182604	0	astrocyte_elevated_gene-1	14,39	AEG-1	41,46	astrocyte elevated gene-1	AEG-1	92140	92140	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of astrocyte_elevated_gene-1 -LRB- AEG-1 -RRB- in human meningiomas and its roles in cell proliferation and survival .
21176342	0	at1	46,49	angiotensin-II_type_1_receptor	15,45	at1	angiotensin-II type 1 receptor	185	185	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Expression of angiotensin-II_type_1_receptor at1 mRNA in myeloid_leukemia -RSB- .
12640452	0	ataxia-telangiectasia_and_Rad3-related_protein	44,90	ATR	92,95	ataxia-telangiectasia and Rad3-related protein	ATR	545	545	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	A splicing mutation affecting expression of ataxia-telangiectasia_and_Rad3-related_protein -LRB- ATR -RRB- results in Seckel_syndrome .
15177184	0	ataxia-telangiectasia_mutated	36,65	ATM	67,70	ataxia-telangiectasia mutated	ATM	472	472	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Biochemical characterization of the ataxia-telangiectasia_mutated -LRB- ATM -RRB- protein from human cells .
18634022	0	ataxia-telangiectasia_mutated	68,97	ATM	99,102	ataxia-telangiectasia mutated	ATM	472	472	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional and computational assessment of missense variants in the ataxia-telangiectasia_mutated -LRB- ATM -RRB- gene : mutations with increased cancer risk .
24324828	0	ataxia-telangiectasia_mutated	36,65	ATM	67,70	ataxia-telangiectasia mutated	ATM	472	472	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation at intronic repeats of the ataxia-telangiectasia_mutated -LRB- ATM -RRB- gene and ATM protein loss in primary gastric_cancer with microsatellite_instability .
24988892	0	ataxia-telangiectasia_mutated	67,96	NF-kappaB	97,106	ataxia-telangiectasia mutated	NF-kappaB	472	4790	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Interleukin_6 augments lung_cancer chemotherapeutic resistance via ataxia-telangiectasia_mutated / NF-kappaB pathway activation .
16952553	0	ataxia-telangiectasia_mutated	15,44	ZBP-89	74,80	ataxia-telangiectasia mutated	ZBP-89	11920(Tax:10090)	22661(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Recruitment of ataxia-telangiectasia_mutated to the p21 -LRB- waf1 -RRB- promoter by ZBP-89 plays a role in mucosal protection .
21502314	0	ataxia-telangiectasia_mutated_and_RAD3-related	127,173	ATR	175,178	ataxia-telangiectasia mutated and RAD3-related	ATR	545	545	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
21502314	0	ataxia-telangiectasia_mutated_and_RAD3-related	127,173	checkpoint_kinase_1	199,218	ataxia-telangiectasia mutated and RAD3-related	checkpoint kinase 1	545	1111	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
16167060	0	ataxia_telangiectasia-mutated	41,70	ATM	72,75	ataxia telangiectasia-mutated	ATM	472	472	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Relation between genetic variants of the ataxia_telangiectasia-mutated -LRB- ATM -RRB- gene , drug resistance , clinical outcome and predisposition to childhood_T-lineage_acute_lymphoblastic_leukaemia .
25301947	0	ataxia_telangiectasia-mutated_and_Rad3-related	142,188	ATR	190,193	ataxia telangiectasia-mutated and Rad3-related	ATR	545	545	Gene	Gene	Signaling|amod|START_ENTITY Signaling|appos|END_ENTITY	Phosphorylation of the BRCA1 C terminus -LRB- BRCT -RRB- repeat inhibitor of hTERT -LRB- BRIT1 -RRB- protein coordinates TopBP1 protein recruitment and amplifies ataxia_telangiectasia-mutated_and_Rad3-related -LRB- ATR -RRB- Signaling .
12673126	0	ataxia_telangiectasia_mutated	15,44	ATM	46,49	ataxia telangiectasia mutated	ATM	472	472	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of ataxia_telangiectasia_mutated -LRB- ATM -RRB- gene mutation/deletion with rhabdomyosarcoma .
12969974	0	ataxia_telangiectasia_mutated	69,98	ATM	100,103	ataxia telangiectasia mutated	ATM	472	472	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of polymorphic variations of the ataxia_telangiectasia_mutated -LRB- ATM -RRB- gene in childhood Hodgkin_disease .
24421316	0	ataxia_telangiectasia_mutated	106,135	ATM	137,140	ataxia telangiectasia mutated	ATM	472	472	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Activation of the prereplication complex is blocked by mimosine through reactive oxygen species-activated ataxia_telangiectasia_mutated -LRB- ATM -RRB- protein without DNA damage .
17526493	0	ataxia_telangiectasia_mutated	66,95	ATR	122,125	ataxia telangiectasia mutated	ATR	472	545	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia_telangiectasia_mutated and Rad3-related protein -LRB- ATR -RRB- to regulate the S-phase checkpoint following UV treatment .
20103595	0	ataxia_telangiectasia_mutated_and_Rad3-related	118,164	ATR	166,169	ataxia telangiectasia mutated and Rad3-related	ATR	545	545	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3 ' - untranslated region of ataxia_telangiectasia_mutated_and_Rad3-related _ -LRB- ATR -RRB- transcript .
18301861	0	ataxin-1	67,75	ATXN-1	77,83	ataxin-1	ATXN-1	6310	6310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Direct and accurate measurement of CAG repeat configuration in the ataxin-1 -LRB- ATXN-1 -RRB- gene by `` dual-fluorescence labeled PCR-restriction fragment length analysis '' .
21835928	0	ataxin-1	18,26	ATXN1	27,32	ataxin-1	ATXN1	6310	6310	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	14-3-3 Binding to ataxin-1 -LRB- ATXN1 -RRB- regulates its dephosphorylation at Ser-776 and transport to the nucleus .
9097953	0	ataxin-1	74,82	SCA1	55,59	ataxin-1	SCA1	6310	6310	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Identification of a self-association region within the SCA1 gene product , ataxin-1 .
21308649	0	ataxin-1	29,37	SUMO-1	0,6	ataxin-1	SUMO-1	20238(Tax:10090)	22218(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SUMO-1 interacts with mutant ataxin-1 and colocalizes to its aggregates in Purkinje cells of SCA1 transgenic_mice .
12093161	0	ataxin-1	52,60	USP7	0,4	ataxin-1	USP7	20238(Tax:10090)	252870(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	USP7 , a ubiquitin-specific protease , interacts with ataxin-1 , the SCA1 gene product .
18519031	0	ataxin-1	114,122	UbcH6	33,38	ataxin-1	UbcH6	6310	7324	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	The ubiquitin-conjugating enzyme UbcH6 regulates the transcriptional repression activity of the SCA1 gene product ataxin-1 .
12757932	0	ataxin-1	59,67	p80_coilin	0,10	ataxin-1	p80 coilin	6310	8161	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	p80_coilin , a coiled body-specific protein , interacts with ataxin-1 , the SCA1 gene product .
11136710	0	ataxin-1	43,51	spinocerebellar_ataxia_type_1	4,33	ataxin-1	spinocerebellar ataxia type 1	20238(Tax:10090)	20238(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	The spinocerebellar_ataxia_type_1 protein , ataxin-1 , has RNA-binding activity that is inversely affected by the length of its polyglutamine tract .
21294677	0	ataxin-3	31,39	ATX3	41,45	ataxin-3	ATX3	4287	4287	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Allele-selective inhibition of ataxin-3 -LRB- ATX3 -RRB- expression by antisense oligomers and duplex RNAs .
17764659	0	ataxin-3	33,41	Atxn3	26,31	ataxin-3	Atxn3	110616(Tax:10090)	110616(Tax:10090)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Inactivation of the mouse Atxn3 -LRB- ataxin-3 -RRB- gene increases protein ubiquitination .
16126176	0	ataxin-3	54,62	Hsp27	22,27	ataxin-3	Hsp27	4287	3315	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Dynamic expression of Hsp27 in the presence of mutant ataxin-3 .
16020535	0	ataxin-3	49,57	Josephin	30,38	ataxin-3	Josephin	4287	4287	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The solution structure of the Josephin domain of ataxin-3 : structural determinants for molecular recognition .
17096206	0	ataxin-3	47,55	Josephin	28,36	ataxin-3	Josephin	4287	4287	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Structure validation of the Josephin domain of ataxin-3 : conclusive evidence for an open conformation .
19382171	0	ataxin-3	19,27	Josephin	0,8	ataxin-3	Josephin	4287	4287	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites .
24251111	0	ataxin-3	114,122	Josephin	95,103	ataxin-3	Josephin	4287	4287	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Enzymatic production of mono-ubiquitinated proteins for structural studies : The example of the Josephin domain of ataxin-3 .
17302910	0	ataxin-3	88,96	p45	0,3	ataxin-3	p45	4287	4778	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	p45 , an ATPase subunit of the 19S proteasome , targets the polyglutamine disease protein ataxin-3 to the proteasome .
23100324	0	ataxin-3	17,25	spinocerebellar_ataxia_type_3	68,97	ataxin-3	spinocerebellar ataxia type 3	110616(Tax:10090)	110616(Tax:10090)	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar_ataxia_type_3 -LRB- SCA3 -RRB- .
15964171	0	ataxin-7	23,31	Bax	112,115	ataxin-7	Bax	6314	581	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Polyglutamine-expanded ataxin-7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl-x -LRB- L -RRB- .
20546728	0	ataxin-7	23,31	Bax	44,47	ataxin-7	Bax	246103(Tax:10090)	12028(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|compound|END_ENTITY	Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons .
21689595	0	ataxin-7	15,23	CTCF	0,4	ataxin-7	CTCF	246103(Tax:10090)	13018(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CTCF regulates ataxin-7 expression through promotion of a convergently transcribed , antisense noncoding RNA .
23236151	0	ataxin-7	45,53	Reelin	0,6	ataxin-7	Reelin	6314	5649	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar_ataxia_type_7 -LRB- SCA7 -RRB- astrocytes .
10681408	0	atherogenic_lipoprotein_phenotype	47,80	hepatic_lipase	20,34	atherogenic lipoprotein phenotype	hepatic lipase	470	3990	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Contribution of the hepatic_lipase gene to the atherogenic_lipoprotein_phenotype in familial combined hyperlipidemia .
9865712	0	atm	8,11	p53	37,40	atm	p53	11920(Tax:10090)	22060(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY radiosensitizes|nsubj|Loss radiosensitizes|dobj|tissues tissues|compound|END_ENTITY	Loss of atm radiosensitizes multiple p53 null tissues .
8980539	0	atp6	105,109	ORF_3	91,96	atp6	ORF 3	4237874(Tax:3708)	1466279(Tax:3708)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Alloplasmic male-sterile Brassica lines containing B. tournefortii mitochondria express an ORF_3 ' of the atp6 gene and a 32 kDa protein .
21167140	0	atp7a	74,79	sod1	10,14	atp7a	sod1	564924(Tax:7955)	30553(Tax:7955)	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|END_ENTITY	Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper_status .
8394952	0	atrial_natriuretic_factor	28,53	ACE	10,13	atrial natriuretic factor	ACE	24602(Tax:10116)	24310(Tax:10116)	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ACE inhibitors on atrial_natriuretic_factor in the brains of rats with reduced renal mass .
11151301	0	atrial_natriuretic_factor	14,39	ANF	41,44	atrial natriuretic factor	ANF	394320(Tax:8355)	394320(Tax:8355)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of atrial_natriuretic_factor -LRB- ANF -RRB- during Xenopus cardiac development .
11895081	0	atrial_natriuretic_factor	57,82	ANF	84,87	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Pressure overload induces heterologous expression of the atrial_natriuretic_factor -LRB- ANF -RRB- gene .
1396230	0	atrial_natriuretic_factor	10,35	ANF	37,40	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of atrial_natriuretic_factor -LRB- ANF -RRB- on water homeostasis of the neonate .
1660404	0	atrial_natriuretic_factor	46,71	ANF	73,76	atrial natriuretic factor	ANF	100009087(Tax:9986)	100009087(Tax:9986)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Experimental_glaucoma significantly decreases atrial_natriuretic_factor -LRB- ANF -RRB- receptors in the ciliary processes of the rabbit eye .
16909307	0	atrial_natriuretic_factor	38,63	ANF	65,68	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	In Vivo beta-adrenergic activation of atrial_natriuretic_factor -LRB- ANF -RRB- reporter expression .
2147459	0	atrial_natriuretic_factor	12,37	ANF	39,42	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Ontogeny|nmod|START_ENTITY Ontogeny|appos|END_ENTITY	Ontogeny of atrial_natriuretic_factor -LRB- ANF -RRB- binding in various areas of the rat brain .
2177369	0	atrial_natriuretic_factor	18,43	ANF	45,48	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- Plasma levels of atrial_natriuretic_factor -LRB- ANF -RRB- in the stroke patients after glycerol and mannitol infusion -RSB- .
2473074	0	atrial_natriuretic_factor	11,36	ANF	38,41	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of atrial_natriuretic_factor -LRB- ANF -RRB- on phenylephrine-triggered intra - and extracellular calcium dependent contraction in rat aorta .
2522951	0	atrial_natriuretic_factor	16,41	ANF	43,46	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of atrial_natriuretic_factor -LRB- ANF -RRB- binding sites in the central nervous system of the frog .
2524722	0	atrial_natriuretic_factor	10,35	ANF	37,40	atrial natriuretic factor	ANF	281355(Tax:9913)	281355(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of atrial_natriuretic_factor -LRB- ANF -RRB- on nicotinic acetylcholine receptor channels in bovine chromaffin cells .
2529306	0	atrial_natriuretic_factor	21,46	ANF	48,51	atrial natriuretic factor	ANF	281355(Tax:9913)	281355(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of synthetic atrial_natriuretic_factor -LRB- ANF -RRB- on renin-aldosterone axis in the conscious newborn calf .
2541712	0	atrial_natriuretic_factor	11,36	ANF	38,41	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of atrial_natriuretic_factor -LRB- ANF -RRB- induced by acute airway_obstruction .
2933267	0	atrial_natriuretic_factor	33,58	ANF	60,63	atrial natriuretic factor	ANF	608289(Tax:9615)	608289(Tax:9615)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Hemodynamic effects of synthetic atrial_natriuretic_factor -LRB- ANF -RRB- in dogs with acute left_ventricular_failure .
2946294	0	atrial_natriuretic_factor	27,52	ANF	54,57	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Hypoxia-induced release of atrial_natriuretic_factor -LRB- ANF -RRB- from the isolated rat and rabbit heart .
2966342	0	atrial_natriuretic_factor	50,75	ANF	77,80	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and identification of immunoreactive atrial_natriuretic_factor -LRB- ANF -RRB- in the frog ventricle .
2973544	0	atrial_natriuretic_factor	16,41	ANF	43,46	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of the atrial_natriuretic_factor -LRB- ANF -RRB- in human ascitic fluid .
2977978	0	atrial_natriuretic_factor	10,35	ANF	37,40	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of atrial_natriuretic_factor -LRB- ANF -RRB- on the secretory activity of zona glomerulosa in sodium-restricted rats .
3158698	0	atrial_natriuretic_factor	41,66	ANF	68,71	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of immunoreactive synthetic atrial_natriuretic_factor -LRB- ANF -RRB- in the heart of various animal species .
8369269	0	atrial_natriuretic_factor	49,74	ANF	76,79	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Functional-morphological effect of the synthetic atrial_natriuretic_factor -LRB- ANF 101-126 -RRB- on the zona glomerulosa cells of adrenal cortex .
8745211	0	atrial_natriuretic_factor	134,159	ANF	161,164	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Influence of fibroblast growth factor -LRB- bFGF -RRB- and insulin-like growth factor -LRB- IGF-I -RRB- on cytoskeletal and contractile structures and on atrial_natriuretic_factor -LRB- ANF -RRB- expression in adult rat ventricular cardiomyocytes in culture .
8745272	0	atrial_natriuretic_factor	54,79	ANF	81,84	atrial natriuretic factor	ANF	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Localization of mRNA coding for the three subtypes of atrial_natriuretic_factor -LRB- ANF -RRB- receptors in rat anterior pituitary gland cells .
8762520	0	atrial_natriuretic_factor	39,64	ANF	66,69	atrial natriuretic factor	ANF	4878	4878	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Study on expression and regulation of atrial_natriuretic_factor -LRB- ANF -RRB- gene in nasal mucosa -RSB- .
9749824	0	atrial_natriuretic_factor	26,51	Adrenomedullin	0,14	atrial natriuretic factor	Adrenomedullin	24602(Tax:10116)	25026(Tax:10116)	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	Adrenomedullin suppresses atrial_natriuretic_factor -LRB- ANF -RRB- secretion from isolated atrium .
15542826	0	atrial_natriuretic_factor	18,43	Jumonji	0,7	atrial natriuretic factor	Jumonji	230899(Tax:10090)	16468(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Jumonji represses atrial_natriuretic_factor gene expression by inhibiting transcriptional activities of cardiac transcription factors .
21930795	0	atrial_natriuretic_factor	49,74	Nkx2-5	21,27	atrial natriuretic factor	Nkx2-5	230899(Tax:10090)	18091(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	Differential role of Nkx2-5 in activation of the atrial_natriuretic_factor gene in the developing versus failing heart .
12692125	0	atrial_natriuretic_factor	37,62	PITX2	0,5	atrial natriuretic factor	PITX2	230899(Tax:10090)	18741(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nummod|END_ENTITY	PITX2 isoform-specific regulation of atrial_natriuretic_factor expression : synergism and repression with Nkx2 .5 .
15466416	0	atrial_natriuretic_factor	32,57	PITX2	70,75	atrial natriuretic factor	PITX2	4878	5308	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Cell-specific activation of the atrial_natriuretic_factor promoter by PITX2 and MEF2A .
2530271	0	atrial_natriuretic_factor	35,60	angiotensin_II	64,78	atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nmod|elevation elevation|amod|END_ENTITY	Effects of intracerebroventricular atrial_natriuretic_factor on angiotensin_II - or sodium-induced blood pressure elevation and natriuresis .
2843514	0	atrial_natriuretic_factor	14,39	angiotensin_II	53,67	atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Regulation of atrial_natriuretic_factor receptors by angiotensin_II in rat vascular smooth muscle cells .
2942948	0	atrial_natriuretic_factor	11,36	angiotensin_II	70,84	atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of atrial_natriuretic_factor on drinking responses to central angiotensin_II .
3023030	0	atrial_natriuretic_factor	24,49	angiotensin_II	53,67	atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	Differential effects of atrial_natriuretic_factor on angiotensin_II - and adrenocorticotropin-stimulated aldosterone secretion .
6242556	0	atrial_natriuretic_factor	24,49	angiotensin_II	62,76	atrial natriuretic factor	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY enhanced|nsubj|response enhanced|nmod|END_ENTITY	Natriuretic response to atrial_natriuretic_factor enhanced by angiotensin_II and vasopressin .
2170515	0	atrial_natriuretic_factor	10,35	angiotensin_converting_enzyme	39,68	atrial natriuretic factor	angiotensin converting enzyme	4878	1636	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on angiotensin_converting_enzyme .
9624601	0	atrial_natriuretic_factor	7,32	corticotropin-releasing_hormone	129,160	atrial natriuretic factor	corticotropin-releasing hormone	4878	1392	Gene	Gene	START_ENTITY|nmod|administration administration|amod|END_ENTITY	Plasma atrial_natriuretic_factor levels in the inferior_petrosal_sinus blood of patients with Cushing 's _ disease before and after corticotropin-releasing_hormone administration .
10555096	0	atrial_natriuretic_factor	33,58	renin	14,19	atrial natriuretic factor	renin	608289(Tax:9615)	403838(Tax:9615)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Modulation of renin secretion by atrial_natriuretic_factor prohormone fragment 31-67 .
1438145	0	atrial_natriuretic_factor	11,36	renin	48,53	atrial natriuretic factor	renin	608289(Tax:9615)	403838(Tax:9615)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Changes in atrial_natriuretic_factor and plasma renin activity in dogs infected with Trypanosoma_brucei .
2148294	0	atrial_natriuretic_factor	55,80	renin	82,87	atrial natriuretic factor	renin	4878	5972	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|dobj|activity activity|amod|END_ENTITY	Relationship between natriuresis and changes in plasma atrial_natriuretic_factor , renin activity and aldosterone levels in fasting obese subjects .
2473345	0	atrial_natriuretic_factor	10,35	renin	39,44	atrial natriuretic factor	renin	24602(Tax:10116)	24715(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on renin and aldosterone .
2522364	0	atrial_natriuretic_factor	38,63	renin	75,80	atrial natriuretic factor	renin	608289(Tax:9615)	403838(Tax:9615)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Effects of hypoxia and hypercapnia on atrial_natriuretic_factor and plasma renin activity in conscious dogs .
2546456	0	atrial_natriuretic_factor	60,85	renin	27,32	atrial natriuretic factor	renin	608289(Tax:9615)	403838(Tax:9615)	Gene	Gene	hypotension|nmod|START_ENTITY Mechanism|acl|hypotension Mechanism|nmod|inhibition inhibition|nmod|response response|compound|END_ENTITY	Mechanism of inhibition of renin response to hypotension by atrial_natriuretic_factor .
2856722	0	atrial_natriuretic_factor	10,35	renin	39,44	atrial natriuretic factor	renin	608289(Tax:9615)	403838(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of atrial_natriuretic_factor on renin secretion , plasma renin and aldosterone in dogs with acute unilateral renal artery constriction .
2941270	0	atrial_natriuretic_factor	8,33	renin	37,42	atrial natriuretic factor	renin	24602(Tax:10116)	24715(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|release release|compound|END_ENTITY	Role of atrial_natriuretic_factor in renin release .
2941371	0	atrial_natriuretic_factor	55,80	renin	36,41	atrial natriuretic factor	renin	608289(Tax:9615)	403838(Tax:9615)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|mechanisms mechanisms|nmod|suppression suppression|nmod|END_ENTITY	Renal mechanisms for suppression of renin secretion by atrial_natriuretic_factor .
2945679	0	atrial_natriuretic_factor	30,55	renin	98,103	atrial natriuretic factor	renin	24602(Tax:10116)	24715(Tax:10116)	Gene	Gene	infusion|nmod|START_ENTITY Effect|nmod|infusion Effect|appos|activity activity|compound|END_ENTITY	Effect of chronic infusion of atrial_natriuretic_factor on plasma and urinary aldosterone , plasma renin activity , blood pressure and sodium excretion in 2-K , 1-C hypertensive rats .
2977168	0	atrial_natriuretic_factor	19,44	renin	154,159	atrial natriuretic factor	renin	4878	5972	Gene	Gene	Increase|nmod|START_ENTITY Increase|dep|effect effect|nmod|activity activity|compound|END_ENTITY	Increase in plasma atrial_natriuretic_factor and right atrial area during endogenous and exogenous volume loading in healthy volunteers : effect on plasma renin activity , aldosterone and antidiuretic_hormone .
2990872	0	atrial_natriuretic_factor	14,39	renin	70,75	atrial natriuretic factor	renin	24602(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|secretion secretion|compound|END_ENTITY	Synthetic rat atrial_natriuretic_factor inhibits in vitro and in vivo renin secretion in rats .
3015641	0	atrial_natriuretic_factor	4,29	renin	41,46	atrial natriuretic factor	renin	24602(Tax:10116)	24715(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Rat atrial_natriuretic_factor stimulates renin release from renal cortical slices .
12270761	0	atrial_natriuretic_peptide	26,52	ANP	54,57	atrial natriuretic peptide	ANP	4878	4878	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Locally different role of atrial_natriuretic_peptide -LRB- ANP -RRB- in the pericardial fluid .
14501129	0	atrial_natriuretic_peptide	54,80	ANP	82,85	atrial natriuretic peptide	ANP	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Crystallization and preliminary X-ray analysis of the atrial_natriuretic_peptide -LRB- ANP -RRB- receptor extracellular domain complex with ANP : use of ammonium_sulfate as the cryosalt .
1533382	1	atrial_natriuretic_peptide	105,131	ANP	133,136	atrial natriuretic peptide	ANP	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects on atrial_natriuretic_peptide -LRB- ANP -RRB- release .
17110362	0	atrial_natriuretic_peptide	121,147	ANP	149,152	atrial natriuretic peptide	ANP	4878	4878	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Normalization of thyroid hormone levels in patients with either hyper - _ or_hypothyroidism results in a profound change of atrial_natriuretic_peptide -LRB- ANP -RRB- levels .
1839083	0	atrial_natriuretic_peptide	58,84	ANP	86,89	atrial natriuretic peptide	ANP	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Effect of adrenal cortical hormones on the expression of atrial_natriuretic_peptide -LRB- ANP -RRB- gene in vivo -RSB- .
1846877	0	atrial_natriuretic_peptide	53,79	ANP	81,84	atrial natriuretic peptide	ANP	4878	4878	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Solubilization and molecular characterization of the atrial_natriuretic_peptide -LRB- ANP -RRB- receptor in human platelets : comparison with ANP receptors in rat tissues .
2137425	0	atrial_natriuretic_peptide	20,46	ANP	48,51	atrial natriuretic peptide	ANP	100009087(Tax:9986)	100009087(Tax:9986)	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Plasmatic levels of atrial_natriuretic_peptide -LRB- ANP -RRB- in drowning .
2146055	0	atrial_natriuretic_peptide	8,34	ANP	36,39	atrial natriuretic peptide	ANP	4878	4878	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	-LSB- Plasma atrial_natriuretic_peptide -LRB- ANP -RRB- levels in Parkinson 's _ disease -- with special reference to foot edema -RSB- .
2441981	0	atrial_natriuretic_peptide	24,50	ANP	52,55	atrial natriuretic peptide	ANP	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The characterization of atrial_natriuretic_peptide -LRB- ANP -RRB- expression by primary cultures of atrial myocytes using an ANP-specific monoclonal antibody and an ANP messenger ribonucleic acid probe .
2526450	0	atrial_natriuretic_peptide	11,37	ANP	39,42	atrial natriuretic peptide	ANP	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of atrial_natriuretic_peptide -LRB- ANP -RRB- on jejunal net fluid absorption in the rat .
2943281	0	atrial_natriuretic_peptide	35,61	ANP	63,66	atrial natriuretic peptide	ANP	281355(Tax:9913)	281355(Tax:9913)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis and activity profiles of atrial_natriuretic_peptide -LRB- ANP -RRB- analogs with reduced ring size .
2963186	0	atrial_natriuretic_peptide	21,47	ANP	49,52	atrial natriuretic peptide	ANP	24602(Tax:10116)	24602(Tax:10116)	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	The concentration of atrial_natriuretic_peptide -LRB- ANP -RRB- is decreased in plasma but not in atria in hypophysectomised rats .
7889288	0	atrial_natriuretic_peptide	31,57	ANP	59,62	atrial natriuretic peptide	ANP	4878	4878	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	The interaction of alpha-human atrial_natriuretic_peptide -LRB- ANP -RRB- with salbutamol , sodium_nitroprusside and isosorbide_dinitrate in human bronchial smooth muscle .
9248576	0	atrial_natriuretic_peptide	34,60	ANP	62,65	atrial natriuretic peptide	ANP	4878	4878	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of atrial_natriuretic_peptide -LRB- ANP -RRB- in the conducting system and internodal atrial myocardium of human hearts .
9080425	0	atrial_natriuretic_peptide	50,76	ANP-B	78,83	atrial natriuretic peptide	ANP-B	116564(Tax:10116)	116564(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Detection of C-type natriuretic peptide -LRB- CNP -RRB- and atrial_natriuretic_peptide -LRB- ANP-B -RRB- receptor mRNAs in rat inner ear .
11354260	0	atrial_natriuretic_peptide	44,70	B-type_natriuretic_peptide	14,40	atrial natriuretic peptide	B-type natriuretic peptide	230899(Tax:10090)	18158(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Expression of B-type_natriuretic_peptide in atrial_natriuretic_peptide gene disrupted mice .
8786548	0	atrial_natriuretic_peptide	26,52	Erythropoietin	0,14	atrial natriuretic peptide	Erythropoietin	24602(Tax:10116)	24335(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Erythropoietin stimulates atrial_natriuretic_peptide secretion from adult rat cardiac atrium .
15336444	0	atrial_natriuretic_peptide	77,103	Protein_kinase_A	0,16	atrial natriuretic peptide	Protein kinase A	24602(Tax:10116)	25636(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Protein_kinase_A dependent signalling mediates anti-apoptotic effects of the atrial_natriuretic_peptide in ischemic livers .
8768694	0	atrial_natriuretic_peptide	20,46	Thrombin	0,8	atrial natriuretic peptide	Thrombin	24602(Tax:10116)	29251(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Thrombin stimulates atrial_natriuretic_peptide secretion from rat cardiac atrium .
9039085	0	atrial_natriuretic_peptide	18,44	Thrombin	0,8	atrial natriuretic peptide	Thrombin	281355(Tax:9913)	280685(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Thrombin inhibits atrial_natriuretic_peptide receptor activity in cultured bovine endothelial cells .
8386485	0	atrial_natriuretic_peptide	50,76	angiotensin_II	11,25	atrial natriuretic peptide	angiotensin II	24602(Tax:10116)	24179(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY modulates|dobj|effect modulates|nsubj|END_ENTITY	Endogenous angiotensin_II modulates the effect of atrial_natriuretic_peptide on extracellular fluid partition .
17264312	0	atrial_natriuretic_peptide	104,130	atrial_natriuretic_peptide	28,54	atrial natriuretic peptide	atrial natriuretic peptide	230899(Tax:10090)	230899(Tax:10090)	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	Renal hyporesponsiveness to atrial_natriuretic_peptide in congestive_heart_failure results from reduced atrial_natriuretic_peptide receptor concentrations .
17264312	0	atrial_natriuretic_peptide	28,54	atrial_natriuretic_peptide	104,130	atrial natriuretic peptide	atrial natriuretic peptide	230899(Tax:10090)	230899(Tax:10090)	Gene	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Renal hyporesponsiveness to atrial_natriuretic_peptide in congestive_heart_failure results from reduced atrial_natriuretic_peptide receptor concentrations .
2468474	0	atrial_natriuretic_peptide	50,76	calcitonin_gene-related_peptide	15,46	atrial natriuretic peptide	calcitonin gene-related peptide	24602(Tax:10116)	24241(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Stimulation by calcitonin_gene-related_peptide of atrial_natriuretic_peptide secretion in vitro and its mechanism of action .
2964553	0	atrial_natriuretic_peptide	10,36	corticotropin-releasing_factor	73,103	atrial natriuretic peptide	corticotropin-releasing factor	24602(Tax:10116)	81648(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effect of atrial_natriuretic_peptide on acetylcholine-induced release of corticotropin-releasing_factor from rat hypothalamus in vitro .
8876664	0	atrial_natriuretic_peptide	15,41	corticotropin_releasing_factor	55,85	atrial natriuretic peptide	corticotropin releasing factor	24602(Tax:10116)	81648(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of atrial_natriuretic_peptide -LRB- ANP1-28 -RRB- on corticotropin_releasing_factor in brain of rats .
17338155	0	atrial_natriuretic_peptide	25,51	endothelin-1	11,23	atrial natriuretic peptide	endothelin-1	608289(Tax:9615)	403424(Tax:9615)	Gene	Gene	START_ENTITY|nsubj|Plasma Plasma|amod|END_ENTITY	Plasma big endothelin-1 , atrial_natriuretic_peptide , aldosterone , and norepinephrine concentrations in normal Doberman Pinschers and Doberman Pinschers with dilated_cardiomyopathy .
2142091	0	atrial_natriuretic_peptide	18,44	endothelin-1	76,88	atrial natriuretic peptide	endothelin-1	24602(Tax:10116)	24323(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	No major role for atrial_natriuretic_peptide in the vasodilator response to endothelin-1 in the spontaneously hypertensive rat .
8477643	0	atrial_natriuretic_peptide	34,60	endothelin-1	13,25	atrial natriuretic peptide	endothelin-1	24602(Tax:10116)	24323(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY inhibit|dobj|secretion inhibit|nsubj|doses doses|nmod|END_ENTITY	Low doses of endothelin-1 inhibit atrial_natriuretic_peptide secretion .
8928891	0	atrial_natriuretic_peptide	11,37	endothelin-1	47,59	atrial natriuretic peptide	endothelin-1	608289(Tax:9615)	403424(Tax:9615)	Gene	Gene	inhibits|advmod|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Endogenous atrial_natriuretic_peptide inhibits endothelin-1 secretion in dogs with severe congestive_heart_failure .
1333608	0	atrial_natriuretic_peptide	23,49	growth_hormone	117,131	atrial natriuretic peptide	growth hormone	24602(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	The role of endogenous atrial_natriuretic_peptide in resting and stress-induced release of corticotropin , prolactin , growth_hormone , and thyroid-stimulating hormone .
9632692	0	atrial_natriuretic_peptide	59,85	guanylyl_cyclase-A	96,114	atrial natriuretic peptide	guanylyl cyclase-A	230899(Tax:10090)	18160(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Dual role for adenine_nucleotides in the regulation of the atrial_natriuretic_peptide receptor , guanylyl_cyclase-A .
7572578	0	atrial_natriuretic_peptide	17,43	insulin-like_growth_factor-1	45,73	atrial natriuretic peptide	insulin-like growth factor-1	4878	3479	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Acute changes in atrial_natriuretic_peptide , insulin-like_growth_factor-1 , and lactate levels during left anterior descending coronary artery angioplasty .
21737535	0	atrial_natriuretic_peptide	48,74	natriuretic_peptide_receptor-A	92,122	atrial natriuretic peptide	natriuretic peptide receptor-A	24602(Tax:10116)	24603(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Glucocorticoids improve renal responsiveness to atrial_natriuretic_peptide by up-regulating natriuretic_peptide_receptor-A expression in the renal inner medullary collecting duct in decompensated heart_failure .
2166655	0	atrial_natriuretic_peptide	10,36	renin	48,53	atrial natriuretic peptide	renin	24602(Tax:10116)	24715(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_peptide on adrenal renin and aldosterone .
16714087	0	atrogin-1	38,47	FBXO25	0,6	atrogin-1	FBXO25	171043(Tax:10116)	364637(Tax:10116)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	FBXO25 , an F-box protein homologue of atrogin-1 , is not induced in atrophying muscle .
21126200	0	atrogin-1	14,23	MAFbx	24,29	atrogin-1	MAFbx	67731(Tax:10090)	67731(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Inhibition of atrogin-1 / MAFbx expression by adenovirus-delivered small hairpin RNAs attenuates muscle_atrophy in fasting mice .
17503969	0	atrophin	36,44	brakeless	11,20	atrophin	brakeless	46156(Tax:7227)	44027(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos .
8965642	0	atrophin-1	12,22	DRPLA	0,5	atrophin-1	DRPLA	1822	1822	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	DRPLA gene -LRB- atrophin-1 -RRB- sequence and mRNA expression in human brain .
16772293	0	aurora-A	23,31	Gadd45a	0,7	aurora-A	Gadd45a	20878(Tax:10090)	13197(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Gadd45a interacts with aurora-A and inhibits its kinase activity .
14674694	0	aurora-B	6,14	HC8	51,54	aurora-B	HC8	9212	5684	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner .
18615013	0	aurora_A	35,43	Polo-like_kinase-1	0,18	aurora A	Polo-like kinase-1	6790	5347	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Polo-like_kinase-1 is activated by aurora_A to promote checkpoint recovery .
19596781	0	aurora_B	14,22	Brd4	61,65	aurora B	Brd4	9212	23476	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of aurora_B expression by the bromodomain protein Brd4 .
19995937	0	aurora_B	44,52	E3_ubiquitin_ligase	16,35	aurora B	E3 ubiquitin ligase	9212	158506	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	The Cul3-KLHL21 E3_ubiquitin_ligase targets aurora_B to midzone microtubules in anaphase and is required for cytokinesis .
22920039	0	aurora_B	27,35	INCENP	52,58	aurora B	INCENP	9212	3619	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human aurora_B in complex with INCENP and VX-680 .
20921135	0	aurora_B	16,24	Sds22	0,5	aurora B	Sds22	9212	5510	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Sds22 regulates aurora_B activity and microtubule-kinetochore interactions at mitosis .
20430883	0	aurora_B	14,22	flotillin-1	56,67	aurora B	flotillin-1	9212	10211	Gene	Gene	Regulation|nmod|START_ENTITY kinase|nsubj|Regulation kinase|nmod|END_ENTITY	Regulation of aurora_B kinase by the lipid raft protein flotillin-1 .
16171786	0	aurora_B	57,65	p53	40,43	aurora B	p53	9212	7157	Gene	Gene	activated|nmod|START_ENTITY END_ENTITY|acl|activated	Survivin inhibits anti-growth effect of p53 activated by aurora_B .
21761347	0	aurora_kinase-A	17,32	GATA-3	73,79	aurora kinase-A	GATA-3	6790	2625	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Estrogen-induced aurora_kinase-A -LRB- AURKA -RRB- gene expression is activated by GATA-3 in estrogen_receptor-positive breast_cancer cells .
19447663	0	aurora_kinase_C	13,28	AURKC	30,35	aurora kinase C	AURKC	6795	6795	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	-LSB- Function of aurora_kinase_C -LRB- AURKC -RRB- in human reproduction -RSB- .
21353399	0	aurora_kinase_C	92,107	AURKC	114,119	aurora kinase C	AURKC	6795	6795	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Confirmation of the high prevalence in Morocco of the homozygous mutation c. 144delC in the aurora_kinase_C gene -LRB- AURKC -RRB- in the teratozoospermia with large-headed spermatozoa -RSB- .
8824709	0	autoantigen_La	82,96	SS-B	97,101	autoantigen La	SS-B	6741	6741	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of a murine autoreactive B cell by immunization with human recombinant autoantigen_La / SS-B : characterization of the autoepitope .
9016572	0	autoantigen_La	24,38	SS-B	40,44	autoantigen La	SS-B	6741	6741	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of the autoantigen_La -LRB- SS-B -RRB- as a dsRNA unwinding enzyme .
9778034	0	autoantigen_La	24,38	SS-B	39,43	autoantigen La	SS-B	6741	6741	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of human autoantigen_La / SS-B as BC1/BC200 RNA-binding protein .
11755821	0	autocrine_motility_factor	54,79	AMF	81,84	autocrine motility factor	AMF	2821	2821	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Regulation of cell motility via high and low affinity autocrine_motility_factor -LRB- AMF -RRB- receptor in human oral squamous_carcinoma cells .
12374700	0	autocrine_motility_factor	73,98	AMF	100,103	autocrine motility factor	AMF	2821	2821	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Antihuman epidermal_growth_factor_receptor_2 antibody herceptin inhibits autocrine_motility_factor -LRB- AMF -RRB- expression and potentiates antitumor effects of AMF inhibitors .
19801670	0	autocrine_motility_factor	25,50	ERK	92,95	autocrine motility factor	ERK	2821	5594	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Phosphoglucose_isomerase / autocrine_motility_factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8 .
19801670	0	autocrine_motility_factor	25,50	Phosphoglucose_isomerase	0,24	autocrine motility factor	Phosphoglucose isomerase	2821	2821	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Phosphoglucose_isomerase / autocrine_motility_factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8 .
15613449	0	autocrine_motility_factor	19,44	phosphoglucose_isomerase	45,69	autocrine motility factor	phosphoglucose isomerase	2821	2821	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Novel roles of the autocrine_motility_factor / phosphoglucose_isomerase in tumor_malignancy .
16126909	0	autocrine_motility_factor	39,64	phosphoglucose_isomerase	14,38	autocrine motility factor	phosphoglucose isomerase	2821	2821	Gene	Gene	expression|compound|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of phosphoglucose_isomerase / autocrine_motility_factor expression by hypoxia .
18301993	0	autocrine_motility_factor	129,154	phosphoglucose_isomerase	155,179	autocrine motility factor	phosphoglucose isomerase	2821	2821	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy : a possible association with autocrine_motility_factor / phosphoglucose_isomerase expression .
10873589	0	autocrine_motility_factor	14,39	phosphohexose_isomerase	40,63	autocrine motility factor	phosphohexose isomerase	2821	2821	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of autocrine_motility_factor / phosphohexose_isomerase in Cos7 cells .
10664629	0	autocrine_motility_factor_receptor	72,106	E-cadherin	28,38	autocrine motility factor receptor	E-cadherin	267	999	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|expression expression|amod|END_ENTITY	Correlation between loss of E-cadherin expression and overexpression of autocrine_motility_factor_receptor in association with progression of human gastric_cancers .
11524731	0	autoimmune_regulator	24,44	AIRE	46,50	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	APECED mutations in the autoimmune_regulator -LRB- AIRE -RRB- gene .
11916620	0	autoimmune_regulator	27,47	AIRE	49,53	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the autoimmune_regulator -LRB- AIRE -RRB- gene in sporadic autoimmune Addison 's _ disease can reveal patients with unidentified autoimmune_polyendocrine_syndrome_type_I .
12542742	0	autoimmune_regulator	12,32	AIRE	34,38	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Role of the autoimmune_regulator -LRB- AIRE -RRB- gene in alopecia areata : strong association of a potentially functional AIRE polymorphism with alopecia_universalis .
16774540	0	autoimmune_regulator	53,73	AIRE	75,79	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Investigation of the p.Ser278Arg polymorphism of the autoimmune_regulator -LRB- AIRE -RRB- gene in alopecia_areata .
17590173	0	autoimmune_regulator	14,34	AIRE	41,45	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of autoimmune_regulator gene -LRB- AIRE -RRB- and T regulatory cells in human thymomas .
17891543	0	autoimmune_regulator	184,204	AIRE	211,215	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	An 8-year-old boy with autoimmune_hepatitis and Candida onychosis as the first symptoms of autoimmune_polyglandular_syndrome -LRB- APS1 -RRB- : identification of a new homozygous mutation in the autoimmune_regulator gene -LRB- AIRE -RRB- .
18616706	0	autoimmune_regulator	18,38	AIRE	40,44	autoimmune regulator	AIRE	326	326	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of the autoimmune_regulator -LRB- AIRE -RRB- gene mutations in a cohort of Italian patients with autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystrophy -LRB- APECED -RRB- and in their relatives .
18616774	0	autoimmune_regulator	4,24	AIRE	31,35	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The autoimmune_regulator gene -LRB- AIRE -RRB- is strongly associated with vitiligo .
20850570	0	autoimmune_regulator	62,82	AIRE	84,88	autoimmune regulator	AIRE	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Recent insights into the role and molecular mechanisms of the autoimmune_regulator -LRB- AIRE -RRB- gene in autoimmunity .
23954874	0	autoimmune_regulator	20,40	AIRE	42,46	autoimmune regulator	AIRE	326	326	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of human autoimmune_regulator -LRB- AIRE -RRB- gene translation by miR-220b .
10720083	0	autoimmune_regulator	31,51	AIRE1	53,58	autoimmune regulator	AIRE1	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A heterozygous deletion of the autoimmune_regulator -LRB- AIRE1 -RRB- gene , autoimmune_thyroid_disease , and type 1 diabetes : no evidence for association .
10593569	0	autoimmune_regulator	69,89	Aire	96,100	autoimmune regulator	Aire	11634(Tax:10090)	11634(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization and complete genomic sequence of the murine autoimmune_regulator gene -LRB- Aire -RRB- .
10940877	0	autoimmune_regulator	41,61	Aire	68,72	autoimmune regulator	Aire	11634(Tax:10090)	11634(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|appos|END_ENTITY	RNA and protein expression of the murine autoimmune_regulator gene -LRB- Aire -RRB- in normal , RelB-deficient and in NOD mouse .
18214467	0	autoimmune_regulator	54,74	Aire	76,80	autoimmune regulator	Aire	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evolutionarily conserved and divergent regions of the autoimmune_regulator -LRB- Aire -RRB- gene : a comparative analysis .
19615461	0	autoimmune_regulator	12,32	Aire	34,38	autoimmune regulator	Aire	326	326	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of autoimmune_regulator -LRB- Aire -RRB- in the development of the immune system .
21303359	0	autoimmune_regulator	31,51	Aire	53,57	autoimmune regulator	Aire	326	326	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression and function of the autoimmune_regulator -LRB- Aire -RRB- gene in non-thymic tissue .
21356351	0	autoimmune_regulator	4,24	cytokeratin_17	243,257	autoimmune regulator	cytokeratin 17	326	3872	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	The autoimmune_regulator -LRB- AIRE -RRB- , which is defective in autoimmune_polyendocrinopathy-candidiasis-ectodermal_dystrophy patients , is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin_17 .
23986436	0	autophagy-related_7	27,46	Cathepsin_B	0,11	autophagy-related 7	Cathepsin B	312647(Tax:10116)	64529(Tax:10116)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Cathepsin_B contributes to autophagy-related_7 -LRB- Atg7 -RRB- - induced nod-like_receptor_3 -LRB- NLRP3 -RRB- - dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line .
12498389	0	autotaxin	14,23	NPP-2	25,30	autotaxin	NPP-2	5168	5168	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of autotaxin -LRB- NPP-2 -RRB- is closely linked to invasiveness of breast_cancer cells .
22140473	0	autotaxin	29,38	Stat3	0,5	autotaxin	Stat3	5168	6774	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Stat3 mediates expression of autotaxin in breast_cancer .
19027716	0	autotaxin	27,36	THP-1	67,72	autotaxin	THP-1	5168	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Lipopolysaccharide induces autotaxin expression in human monocytic THP-1 cells .
21489790	0	autotaxin	66,75	lysophospholipase	34,51	autotaxin	lysophospholipase	5168	151056	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin .
16671772	0	autotaxin	65,74	lysophospholipase_D	45,64	autotaxin	lysophospholipase D	5168	5168	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Fluorogenic phospholipid substrate to detect lysophospholipase_D / autotaxin activity .
12176993	0	autotaxin	97,106	plasma_lysophospholipase_D	24,50	autotaxin	plasma lysophospholipase D	5168	5168	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human plasma_lysophospholipase_D , a lysophosphatidic_acid-producing enzyme , as autotaxin , a multifunctional phosphodiesterase .
26031938	0	auxilin	37,44	Swa2	0,4	auxilin	Swa2	9829	851918(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Swa2 , the yeast homolog of mammalian auxilin , is specifically required for the propagation of the prion variant -LSB- URE3-1 -RSB- .
10073940	0	axin	77,81	D-axin	45,51	axin	D-axin	43565(Tax:7227)	43565(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Negative regulation of Wingless signaling by D-axin , a Drosophila homolog of axin .
10581160	0	axin	35,39	GSK3beta	2,10	axin	GSK3beta	8312	2932	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression .
19075000	0	axin	26,30	N-cadherin	0,10	axin	N-cadherin	12005(Tax:10090)	12558(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling , osteoblast function , and bone formation .
16881048	0	axin	22,26	Notch	0,5	axin	Notch	43565(Tax:7227)	31293(Tax:7227)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Notch synergizes with axin to regulate the activity of armadillo in Drosophila .
15228590	0	axin	45,49	Synaptic_scaffolding_molecule	0,29	axin	Synaptic scaffolding molecule	79257(Tax:10116)	113970(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Synaptic_scaffolding_molecule interacts with axin .
10421629	0	axin	33,37	beta-catenin	47,59	axin	beta-catenin	8312	1499	Gene	Gene	dephosphorylation|nmod|START_ENTITY releases|nsubj|dephosphorylation releases|dobj|END_ENTITY	Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex .
10421629	0	axin	69,73	beta-catenin	47,59	axin	beta-catenin	8312	1499	Gene	Gene	complex|compound|START_ENTITY releases|nmod|complex releases|dobj|END_ENTITY	Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex .
10581160	0	axin	35,39	beta-catenin	67,79	axin	beta-catenin	8312	1499	Gene	Gene	site|nmod|START_ENTITY modulates|nsubj|site modulates|nmod|expression expression|amod|END_ENTITY	A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression .
12297048	0	axin	77,81	beta-catenin	100,112	axin	beta-catenin	8312	1499	Gene	Gene	independent|nmod|START_ENTITY phosphorylation|nmod|independent phosphorylation|dep|implications implications|nmod|activation activation|amod|END_ENTITY	Presenilin couples the paired phosphorylation of beta-catenin independent of axin : implications for beta-catenin activation in tumorigenesis .
12297048	0	axin	77,81	beta-catenin	49,61	axin	beta-catenin	8312	1499	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Presenilin couples the paired phosphorylation of beta-catenin independent of axin : implications for beta-catenin activation in tumorigenesis .
9501208	0	axin	63,67	beta-catenin	12,24	axin	beta-catenin	8312	1499	Gene	Gene	synthase|nmod|START_ENTITY synthase|nsubj|Bridging Bridging|nmod|END_ENTITY	Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription .
9554852	0	axin	29,33	beta-catenin	59,71	axin	beta-catenin	398097(Tax:8355)	399274(Tax:8355)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of an axin homolog , conductin , with beta-catenin , APC , and GSK3beta .
15766563	0	axin2	58,63	E2F1	0,4	axin2	E2F1	8313	1869	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation .
16230391	0	axl	48,51	receptor_tyrosine_kinase	23,47	axl	receptor tyrosine kinase	558	5979	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Multiple roles for the receptor_tyrosine_kinase axl in tumor formation .
12142464	0	axonemal_heavy_chain_dynein_type_11	25,60	DNAH11	17,23	axonemal heavy chain dynein type 11	DNAH11	8701	8701	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the DNAH11 -LRB- axonemal_heavy_chain_dynein_type_11 -RRB- gene cause one form of situs inversus totalis and most likely primary ciliary_dyskinesia .
9543336	0	axonin-1	69,77	TAG-1	63,68	axonin-1	TAG-1	21367(Tax:10090)	21367(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of the axon growth-related neural adhesion molecule TAG-1 / axonin-1 in the adult mouse brain .
15670816	0	axotrophin	60,70	Leukaemia_inhibitory_factor	0,27	axotrophin	Leukaemia inhibitory factor	57438(Tax:10090)	16878(Tax:10090)	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	Leukaemia_inhibitory_factor -LRB- LIF -RRB- is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance .
20531225	0	b-5p	14,18	endothelin-1	28,40	b-5p	endothelin-1	574523(Tax:10116)	24323(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	MicroRNA-125a / b-5p inhibits endothelin-1 expression in vascular endothelial cells .
21234673	0	b-Adrenergic_receptors	0,22	VEGF	39,43	b-Adrenergic receptors	b-AR	154	154	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|production production|amod|END_ENTITY	b-Adrenergic_receptors -LRB- b-AR -RRB- regulate VEGF and IL-6 production by divergent pathways in high b-AR-expressing breast_cancer cell lines .
22701179	0	b-Catenin	13,22	CCN1	0,4	b-Catenin	CCN1	1499	890	Gene	Gene	Translocation|compound|START_ENTITY Translocation|compound|END_ENTITY	CCN1 Induces b-Catenin Translocation in Esophageal_Squamous_Cell_Carcinoma through Integrin a11 .
23066445	0	b-Catenin	43,52	Cyclin_D1	14,23	b-Catenin	Cyclin D1	1499	595	Gene	Gene	Expression|amod|START_ENTITY Associated|nmod|Expression Associated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Cyclin_D1 Is Associated with b-Catenin Expression and Correlates with Good Prognosis in Colorectal_Adenocarcinoma .
24268141	0	b-Catenin	0,9	E-cadherin	64,74	b-Catenin	E-cadherin	1499	999	Gene	Gene	serves|nsubj|START_ENTITY serves|nmod|clutch clutch|nmod|strengths strengths|amod|END_ENTITY	b-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths .
25546293	0	b-Catenin	73,82	HDAC6	0,5	b-Catenin	HDAC6	1499	10013	Gene	Gene	Acetylation|nmod|START_ENTITY Acetylation|compound|END_ENTITY	HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of b-Catenin in Human iPSC-Derived Neuronal Cells .
24291232	0	b-Catenin	0,9	Sox2	93,97	b-Catenin	Sox2	1499	6657	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	b-Catenin , a Sox2 binding partner , regulates the DNA binding and transcriptional activity of Sox2 in breast_cancer cells .
20843298	0	b-Catenin	0,9	TGF-b1	51,57	b-Catenin	TGF-b1	1499	7040	Gene	Gene	GTPases|nsubj|START_ENTITY GTPases|nmod|targets targets|nmod|END_ENTITY	b-Catenin and Rho GTPases as downstream targets of TGF-b1 during pulp repair .
22706027	0	b-Catenin	0,9	TGF-b1	34,40	b-Catenin	TGF-b1	1499	7040	Gene	Gene	pathway|amod|START_ENTITY required|nsubjpass|pathway required|nmod|inhibition inhibition|compound|END_ENTITY	b-Catenin pathway is required for TGF-b1 inhibition of PPARy expression in cultured hepatic stellate cells .
26849661	0	b-Catenin	0,9	p16	96,99	b-Catenin	p16	1499	1029	Gene	Gene	Expression|amod|START_ENTITY Expression|dep|Comparison Comparison|nmod|END_ENTITY	b-Catenin Expression in Oropharyngeal_Squamous_Cell_Carcinomas : Comparison and Correlation with p16 and Human_Papillomavirus in situ Hybridization .
16634529	0	b-FGF	44,49	basic-fibroblast_growth_factor	12,42	b-FGF	basic-fibroblast growth factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of basic-fibroblast_growth_factor -LRB- b-FGF -RRB- in cyclosporine-induced nephrotoxicity .
24318128	0	b-TRCP	4,10	MTSS1	19,24	b-TRCP	MTSS1	8945	9788	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	SCF b-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration .
24261825	0	b-TrCP	25,31	Mcl-1	80,85	b-TrCP	Mcl-1	8945	4170	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|degradation degradation|compound|END_ENTITY	The E3 ubiquitin ligases b-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1 , resulting in apoptosis .
23583392	0	b-TrCP	18,24	TRF1	52,56	b-TrCP	TRF1	8945	7013	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	The F-box protein b-TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells .
23648941	0	b-amyloid_precursor_protein	20,47	APP	49,52	b-amyloid precursor protein	APP	351	39399(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ras signal triggers b-amyloid_precursor_protein -LRB- APP -RRB- expression .
23437103	0	b-catenin	28,37	ABCD2	0,5	b-catenin	ABCD2	1499	225	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	ABCD2 is a direct target of b-catenin and TCF-4 : implications for X-linked_adrenoleukodystrophy therapy .
25646597	0	b-catenin	0,9	AKT	100,103	b-catenin	AKT	1499	207	Gene	Gene	knockdown|amod|START_ENTITY inhibits|nsubj|knockdown inhibits|dobj|proliferation proliferation|acl|interfering interfering|nmod|END_ENTITY	b-catenin knockdown inhibits pituitary_adenoma cell proliferation and invasion via interfering with AKT and gelatinases expression .
24496450	0	b-catenin	67,76	APC	80,83	b-catenin	APC	1499	324	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the phosphorylation and nuclear import and export of b-catenin by APC and its cancer-related truncated form .
23660959	6	b-catenin	704,713	ATL	664,667	b-catenin	TCF	1499	3172	Gene	Gene	levels|nmod|START_ENTITY express|dobj|levels express|nsubj|cells cells|compound|END_ENTITY	Our study demonstrated that ATL cells do not express high levels of b-catenin but displayed high levels of LEF-1 / TCF genes along with elevated levels of b-catenin -LRB- LEF-1 / TCF target genes -RRB- responsive genes .
23672191	0	b-catenin	136,145	Akt	209,212	b-catenin	Akt	1499	207	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	ARS-interacting_multi-functional_protein_1 induces proliferation of human bone marrow-derived mesenchymal stem cells by accumulation of b-catenin via fibroblast_growth_factor_receptor_2-mediated activation of Akt .
25079689	0	b-catenin	28,37	Akt	71,74	b-catenin	Akt	1499	207	Gene	Gene	signaling|amod|START_ENTITY suppression|nmod|signaling suppression|dep|evidence evidence|nmod|roles roles|nmod|END_ENTITY	IFNy-induced suppression of b-catenin signaling : evidence for roles of Akt and 14.3.3 .
22431469	0	b-catenin	41,50	Astrocyte_elevated_gene-1	0,25	b-catenin	Astrocyte elevated gene-1	1499	92140	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Astrocyte_elevated_gene-1 interacts with b-catenin and increases migration and invasion of colorectal_carcinoma .
26003048	0	b-catenin	32,41	CCR9	72,76	b-catenin	CCR9	1499	10803	Gene	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	CCR9-mediated signaling through b-catenin and identification of a novel CCR9 antagonist .
22576689	0	b-catenin	64,73	CD43	17,21	b-catenin	CD43	1499	6693	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Leukocyte marker CD43 promotes cell growth in co-operation with b-catenin in non-hematopoietic_cancer cells .
23499736	0	b-catenin	84,93	CEACAM1	0,7	b-catenin	CEACAM1	1499	634	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with b-catenin .
23442321	0	b-catenin	103,112	CTNNB1	114,120	b-catenin	CTNNB1	1499	1499	Gene	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	Prospective analysis of body mass index , physical activity , and colorectal_cancer risk associated with b-catenin -LRB- CTNNB1 -RRB- status .
24117889	0	b-catenin	42,51	CaMKII	0,6	b-catenin	CaMKII	1499	818	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	CaMKII represses transcriptionally active b-catenin to mediate acute ethanol neurodegeneration and can phosphorylate b-catenin .
26212035	0	b-catenin	96,105	DDX5	0,4	b-catenin	DDX5	1499	1655	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	DDX5 promotes proliferation and tumorigenesis of non-small-cell_lung_cancer cells by activating b-catenin signaling pathway .
21884207	0	b-catenin	25,34	E-cadherin	61,71	b-catenin	E-cadherin	1499	999	Gene	Gene	translocation|nmod|START_ENTITY synchronized|nsubj|translocation synchronized|nmod|loss loss|nmod|END_ENTITY	Nuclear translocation of b-catenin synchronized with loss of E-cadherin in oral_epithelial_dysplasia with a characteristic two-phase appearance .
22098108	0	b-catenin	102,111	E-cadherin	58,68	b-catenin	E-cadherin	1499	999	Gene	Gene	signaling|amod|START_ENTITY modulation|nmod|signaling modulation|nmod|expression expression|amod|END_ENTITY	Inhibition of IGF-1 signaling by genistein : modulation of E-cadherin expression and downregulation of b-catenin signaling in hormone refractory PC-3 prostate_cancer cells .
22209340	0	b-catenin	42,51	E-cadherin	53,63	b-catenin	E-cadherin	1499	999	Gene	Gene	chain|amod|START_ENTITY chain|amod|END_ENTITY	Immunohistochemical expression profile of b-catenin , E-cadherin , P-cadherin , laminin-5y2 chain , and SMAD4 in colorectal_serrated_adenocarcinoma .
23355201	0	b-catenin	41,50	E-cadherin	17,27	b-catenin	E-cadherin	1499	999	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Combined loss of E-cadherin and aberrant b-catenin protein expression correlates with a poor prognosis for small intestinal_adenocarcinomas .
25039920	0	b-catenin	91,100	E-cadherin	71,81	b-catenin	E-cadherin	1499	999	Gene	Gene	re-localisation|amod|START_ENTITY induces|dobj|re-localisation induces|nsubj|Secretory_Leukocyte_Protease_Inhibitor Secretory_Leukocyte_Protease_Inhibitor|dep|END_ENTITY	Secretory_Leukocyte_Protease_Inhibitor -LRB- SLPI -RRB- expression downregulates E-cadherin , induces b-catenin re-localisation and triggers apoptosis-related events in breast_cancer cells .
26081960	0	b-catenin	41,50	E-cadherin	19,29	b-catenin	E-cadherin	1499	999	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The expression of E-cadherin , vimentin , b-catenin , transforming_growth_factor-b1 in oral_squamous_cell_carcinomas -RSB- .
26316041	0	b-catenin	31,40	E-cadherin	0,10	b-catenin	E-cadherin	1499	999	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|knockdown knockdown|amod|END_ENTITY	E-cadherin knockdown increases b-catenin reducing colorectal_cancer chemosensitivity only in three-dimensional cultures .
25966221	0	b-catenin	29,38	EpCAM	14,19	b-catenin	EpCAM	1499	4072	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of EpCAM and Wnt / b-catenin in human colon_cancer .
23211523	0	b-catenin	0,9	FSHb	33,37	b-catenin	FSHb	1499	2488	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	b-catenin regulates GnRH-induced FSHb gene expression .
25046247	0	b-catenin	102,111	Fibroblast_activation_protein	0,29	b-catenin	Fibroblast activation protein	1499	2191	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Fibroblast_activation_protein protects bortezomib-induced apoptosis in multiple myeloma cells through b-catenin signaling pathway .
24021281	0	b-catenin	31,40	Focal_adhesion_kinase	0,21	b-catenin	Focal adhesion kinase	1499	5747	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Focal_adhesion_kinase mediates b-catenin signaling in periodontal ligament cells .
24696416	0	b-catenin	21,30	HMGA1	0,5	b-catenin	HMGA1	1499	3159	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HMGA1 interacts with b-catenin to positively regulate Wnt/b-catenin signaling in colorectal_cancer cells .
24954509	0	b-catenin	19,28	HSF1	0,4	b-catenin	HSF1	1499	3297	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	HSF1 regulation of b-catenin in mammary cancer cells through control of HuR/elavL1 expression .
26477825	0	b-catenin	121,130	IL-23	108,113	b-catenin	IL-23	1499	51561	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23 / IL-23R / b-catenin pathway .
26477825	0	b-catenin	121,130	IL-23R	114,120	b-catenin	IL-23R	1499	149233	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Macrophages derived from THP-1 promote the osteogenic differentiation of mesenchymal stem cells through the IL-23 / IL-23R / b-catenin pathway .
27044294	0	b-catenin	55,64	Insulin-like_growth_factor_binding_protein-2	0,44	b-catenin	Insulin-like growth factor binding protein-2	1499	3485	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein-2 regulates b-catenin signaling pathway in glioma cells and together contributes to poor patient prognosis .
27015363	0	b-catenin	108,117	MALAT1	19,25	b-catenin	MALAT1	1499	378938	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	Long noncoding RNA MALAT1 promotes malignant development of esophageal_squamous_cell_carcinoma by targeting b-catenin via Ezh2 .
20589835	0	b-catenin	34,43	MT1-MMP	14,21	b-catenin	MT1-MMP	1499	4323	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of MT1-MMP activity by b-catenin in MDCK non-cancer and HT1080 cancer cells .
21239045	0	b-catenin	54,63	Mammalian_target_of_rapamycin	0,29	b-catenin	Mammalian target of rapamycin	1499	2475	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Mammalian_target_of_rapamycin regulates expression of b-catenin in hepatocellular_carcinoma .
22962603	0	b-catenin	16,25	MiR-214	0,7	b-catenin	MiR-214	1499	406996	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MiR-214 targets b-catenin pathway to suppress invasion , stem-like traits and recurrence of human hepatocellular_carcinoma .
21880738	0	b-catenin	33,42	Mixed_lineage_kinase_3	0,22	b-catenin	Mixed lineage kinase 3	1499	4296	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Mixed_lineage_kinase_3 modulates b-catenin signaling in cancer cells .
24130899	0	b-catenin	25,34	Nef	6,9	b-catenin	Nef	1499	6285	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HIV 's Nef interacts with b-catenin of the Wnt signaling pathway in HEK293 cells .
22110128	0	b-catenin	47,56	Nup62	124,129	b-catenin	Nup62	1499	23636	Gene	Gene	transport|amod|START_ENTITY transport|nmod|END_ENTITY	Specific armadillo repeat sequences facilitate b-catenin nuclear transport in live cells via direct binding to nucleoporins Nup62 , Nup153 , and RanBP2/Nup358 .
20847229	0	b-catenin	34,43	Nur77	14,19	b-catenin	Nur77	1499	3164	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of Nur77 expression by b-catenin and its mitogenic effect in colon_cancer cells .
21986938	0	b-catenin	14,23	Nur77	82,87	b-catenin	Nur77	1499	3164	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|acl|signaling signaling|nmod|action action|nmod|END_ENTITY	Inhibition of b-catenin signaling by nongenomic action of orphan nuclear receptor Nur77 .
24700702	0	b-catenin	28,37	Oct-4	54,59	b-catenin	Oct-4	1499	5460	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Association of differential b-catenin expression with Oct-4 and Nanog in oral_squamous_cell_carcinoma and their correlation with clinicopathological factors and prognosis .
22610277	0	b-catenin	0,9	PI3K	32,36	b-catenin	PI3K	1499	5293	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	b-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon_cancer .
23583404	0	b-catenin	84,93	PI3K	0,4	b-catenin	PI3K	1499	5295	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	PI3K is required for the physical interaction and functional inhibition of NF-kB by b-catenin in colorectal_cancer cells .
21196815	0	b-catenin	80,89	Pancreatic_adenocarcinoma_up-regulated_factor	0,45	b-catenin	Pancreatic adenocarcinoma up-regulated factor	1499	124220	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Pancreatic_adenocarcinoma_up-regulated_factor -LRB- PAUF -RRB- enhances the expression of b-catenin , leading to a rapid proliferation of pancreatic cells .
25969134	0	b-catenin	39,48	Par-4	0,5	b-catenin	Par-4	1499	347745	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Par-4 dependent modulation of cellular b-catenin by medicinal plant natural product derivative 3-azido_Withaferin_A .
25771860	0	b-catenin	75,84	ROCK2	0,5	b-catenin	ROCK2	1499	9475	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	ROCK2 promotes HCC proliferation by CEBPD inhibition through phospho-GSK3b / b-catenin signaling .
26505794	0	b-catenin	17,26	Rock2	0,5	b-catenin	Rock2	1499	9475	Gene	Gene	stabilizes|xcomp|START_ENTITY stabilizes|nsubj|END_ENTITY	Rock2 stabilizes b-catenin to promote tumor invasion and metastasis in colorectal_cancer .
24520423	0	b-catenin	0,9	Runx2	92,97	b-catenin	Runx2	1499	860	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|activation activation|nmod|END_ENTITY	b-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2 .
24975844	0	b-catenin	28,37	S100A4	0,6	b-catenin	S100A4	1499	6275	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	S100A4 negatively regulates b-catenin by inducing the Egr-1-PTEN-Akt-GSK3b degradation pathway .
22560296	0	b-catenin	41,50	S100A6	0,6	b-catenin	S100A6	1499	6277	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	S100A6 is transcriptionally regulated by b-catenin and interacts with a novel target , lamin_A / C , in colorectal_cancer cells .
26044826	0	b-catenin	36,45	S100A6	10,16	b-catenin	S100A6	1499	6277	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|over-expression over-expression|compound|END_ENTITY	Effect of S100A6 over-expression on b-catenin in endometriosis .
24809782	0	b-catenin	51,60	SERPINB3	0,8	b-catenin	SERPINB3	1499	6317	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	SERPINB3 is associated with TGF-b1 and cytoplasmic b-catenin expression in hepatocellular_carcinomas with poor prognosis .
25869100	0	b-catenin	14,23	STAT-3	133,139	b-catenin	STAT-3	1499	6774	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of b-catenin signaling suppresses pancreatic_tumor growth by disrupting nuclear b-catenin/TCF -1 complex : critical role of STAT-3 .
20830236	0	b-catenin	73,82	STAT3	0,5	b-catenin	STAT3	1499	6774	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	STAT3 upregulates the protein expression and transcriptional activity of b-catenin in breast_cancer .
25348333	0	b-catenin	31,40	STAT3	0,5	b-catenin	STAT3	1499	6774	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	STAT3 paradoxically stimulates b-catenin expression but inhibits b-catenin function .
24561244	0	b-catenin	25,34	Skp2	10,14	b-catenin	Skp2	1499	6502	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	E3-ligase Skp2 regulates b-catenin expression and maintains hematopoietic stem cell homing .
22231735	0	b-catenin	42,51	Sox4	0,4	b-catenin	Sox4	1499	6659	Gene	Gene	regulator|nmod|START_ENTITY functions|nmod|regulator functions|amod|END_ENTITY	Sox4 functions as a positive regulator of b-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial_carcinomas .
23068607	0	b-catenin	66,75	T-cell_factor	52,65	b-catenin	T-cell factor	1499	3172	Gene	Gene	signaling|dep|START_ENTITY signaling|nsubj|/ /|compound|END_ENTITY	NDRG2 and PRA1 interact and synergistically inhibit T-cell_factor / b-catenin signaling .
22231735	0	b-catenin	42,51	TCF4	86,90	b-catenin	TCF4	1499	6925	Gene	Gene	regulator|nmod|START_ENTITY functions|nmod|regulator functions|acl|signaling signaling|nmod|upregulation upregulation|nmod|END_ENTITY	Sox4 functions as a positive regulator of b-catenin signaling through upregulation of TCF4 during morular differentiation of endometrial_carcinomas .
24982424	0	b-catenin	91,100	TCF4	102,106	b-catenin	TCF4	1499	6925	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	CREPT/RPRD1B , a recently identified novel protein highly expressed in tumors , enhances the b-catenin TCF4 transcriptional activity in response to Wnt signaling .
26350900	0	b-catenin	65,74	TCF4	91,95	b-catenin	TCF4	1499	6934	Gene	Gene	downstream|nmod|START_ENTITY inhibits|dobj|downstream inhibits|nmod|END_ENTITY	The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated b-catenin by sequestering TCF4 to the nuclear membrane .
24809782	0	b-catenin	51,60	TGF-b1	28,34	b-catenin	TGF-b1	1499	7040	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	SERPINB3 is associated with TGF-b1 and cytoplasmic b-catenin expression in hepatocellular_carcinomas with poor prognosis .
24623448	0	b-catenin	0,9	TNFRSF19	39,47	b-catenin	TNFRSF19	1499	55504	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	b-catenin regulates NF-kB activity via TNFRSF19 in colorectal_cancer cells .
24379239	0	b-catenin	43,52	TRAIL	14,19	b-catenin	TRAIL	1499	8743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of TRAIL receptor expression by b-catenin in colorectal_tumours .
23280703	0	b-catenin	21,30	TWIST	0,5	b-catenin	TWIST	1499	7291	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TWIST interacts with b-catenin signaling on osteosarcoma cell survival against cisplatin .
23640056	0	b-catenin	34,43	Tissue_transglutaminase	0,23	b-catenin	Tissue transglutaminase	1499	7052	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Tissue_transglutaminase regulates b-catenin signaling through a c-Src-dependent mechanism .
23640056	0	b-catenin	34,43	Tissue_transglutaminase	0,23	b-catenin	Tissue transglutaminase	1499	7052	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Tissue_transglutaminase regulates b-catenin signaling through a c-Src-dependent mechanism .
25175023	0	b-catenin	39,48	Transforming_growth_factor_b	0,28	b-catenin	Transforming growth factor b	1499	7040	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor_b regulates b-catenin expression in lung fibroblast through NF-kB dependent pathway .
23727580	0	b-catenin	61,70	Tubulin_polymerization_promoting_protein_1	0,42	b-catenin	Tubulin polymerization promoting protein 1	1499	11076	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Tubulin_polymerization_promoting_protein_1 -LRB- TPPP1 -RRB- increases b-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells .
26717875	0	b-catenin	0,9	USP9x	26,31	b-catenin	USP9x	1499	8239	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	b-catenin is regulated by USP9x and mediates resistance to TRAIL-induced apoptosis in breast_cancer .
26246285	0	b-catenin	131,140	Wnt5a	0,5	b-catenin	Wnt5a	1499	7474	Gene	Gene	effects|nmod|START_ENTITY attenuates|dobj|effects attenuates|nsubj|END_ENTITY	Wnt5a attenuates the pathogenic effects of the Wnt/b-catenin pathway in human retinal pigment epithelial cells via down-regulating b-catenin and Snail .
26246285	0	b-catenin	131,140	Wnt5a	0,5	b-catenin	Wnt5a	1499	7474	Gene	Gene	effects|nmod|START_ENTITY attenuates|dobj|effects attenuates|nsubj|END_ENTITY	Wnt5a attenuates the pathogenic effects of the Wnt/b-catenin pathway in human retinal pigment epithelial cells via down-regulating b-catenin and Snail .
23285165	0	b-catenin	46,55	amphiregulin	14,26	b-catenin	amphiregulin	1499	374	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of amphiregulin gene expression by b-catenin signaling in human hepatocellular_carcinoma cells : a novel crosstalk between FGF19 and the EGFR system .
23108410	0	b-catenin	40,49	c-Myc	59,64	b-catenin	c-Myc	1499	4609	Gene	Gene	activation|nmod|START_ENTITY promotes|nsubj|activation promotes|dobj|expression expression|amod|END_ENTITY	Hepatitis_C virus-induced activation of b-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events .
25663530	0	b-catenin	0,9	c-Myc	20,25	b-catenin	c-Myc	1499	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	b-catenin regulates c-Myc and CDKN1A expression in breast_cancer cells .
22686277	0	b-catenin	84,93	caspase_3	100,109	b-catenin	caspase 3	1499	836	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical investigation of cell cycle and apoptosis regulators -LRB- survivin , b-catenin , p53 , caspase_3 -RRB- in canine appendicular_osteosarcoma .
24535143	0	b-catenin	44,53	claudin_1	18,27	b-catenin	claudin 1	1499	9076	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|nmod|END_ENTITY	The expression of claudin_1 correlates with b-catenin and is a prognostic factor of poor outcome in gastric_cancer .
26135564	0	b-catenin	38,47	cyclin_D1	83,92	b-catenin	cyclin D1	1499	58919(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Glucagon phosphorylates serine 552 of b-catenin leading to increased expression of cyclin_D1 and c-Myc in the isolated rat liver .
25209444	0	b-catenin	67,76	epidermal_growth_factor_receptor	99,131	b-catenin	epidermal growth factor receptor	1499	1956	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Human_papillomavirus_16 oncoprotein regulates the translocation of b-catenin via the activation of epidermal_growth_factor_receptor .
25487922	0	b-catenin	14,23	estrogen_receptor	78,95	b-catenin	estrogen receptor	1499	2099	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of b-catenin stimulated by mechanical strain and estrogen requires estrogen_receptor in mesenchymal stem cells -LRB- MSCs -RRB- .
22010210	0	b-catenin	123,132	glycogen_synthase_kinase_3b	95,122	b-catenin	glycogen synthase kinase 3b	1499	2932	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Impaired wound healing in hypoxic renal tubular cells : roles of hypoxia-inducible factor-1 and glycogen_synthase_kinase_3b / b-catenin signaling .
23107296	0	b-catenin	35,44	integrin-linked_kinase	12,34	b-catenin	integrin-linked kinase	1499	3611	Gene	Gene	pathway|amod|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	The role of integrin-linked_kinase / b-catenin pathway in the enhanced MG63 differentiation by micro/nano-textured topography .
26361959	0	b-catenin	14,23	leupaxin	50,58	b-catenin	leupaxin	1499	9404	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Regulation of b-catenin transcription activity by leupaxin in hepatocellular_carcinoma .
26493274	0	b-catenin	125,134	p16	105,108	b-catenin	p16	1499	1029	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	A novel prediction model for human_papillomavirus-associated oropharyngeal_squamous_cell_carcinoma using p16 and subcellular b-catenin expression .
21561764	0	b-catenin	54,63	retinoid_X_receptor_alpha	15,40	b-catenin	retinoid X receptor alpha	1499	6256	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Suppression of retinoid_X_receptor_alpha and aberrant b-catenin expression significantly associates with progression of colorectal_carcinoma .
22894902	0	b-catenin	67,76	telomerase_reverse_transcriptase	6,38	b-catenin	telomerase reverse transcriptase	1499	7015	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- is a target gene of b-catenin in human colorectal_tumors .
26081960	0	b-catenin	41,50	transforming_growth_factor-b1	52,81	b-catenin	transforming growth factor-b1	1499	7040	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The expression of E-cadherin , vimentin , b-catenin , transforming_growth_factor-b1 in oral_squamous_cell_carcinomas -RSB- .
23728330	0	b-secretase	59,70	BACE1	72,77	b-secretase	BACE1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure-activity relationships for bergenin analogues as b-secretase -LRB- BACE1 -RRB- inhibitors .
22380629	0	b-site_APP-cleaving_enzyme_1	71,99	BACE1	101,106	b-site APP-cleaving enzyme 1	BACE1	23821(Tax:10090)	23821(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of cyclic_sulfone_hydroxyethylamines as potent and selective b-site_APP-cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors : structure-based design and in vivo reduction of amyloid b-peptides .
23981898	0	b-site_APP-cleaving_enzyme_1	73,101	BACE1	103,108	b-site APP-cleaving enzyme 1	BACE1	23821(Tax:10090)	23821(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of cyclic_sulfoxide_hydroxyethylamines as potent and selective b-site_APP-cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors : structure based design and in vivo reduction of amyloid b-peptides .
23509904	0	b-site_APP_cleaving_enzyme_1	26,54	BACE1	56,61	b-site APP cleaving enzyme 1	BACE1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure-based design of b-site_APP_cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors for the treatment of Alzheimer 's _ disease .
24397738	0	b-site_amyloid_precursor_protein_cleaving_enzyme_1	46,96	BACE1	98,103	b-site amyloid precursor protein cleaving enzyme 1	BACE1	100135485(Tax:10141)	100135485(Tax:10141)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of 7-tetrahydropyran-2-yl_chromans : b-site_amyloid_precursor_protein_cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors that reduce amyloid b-protein -LRB- Ab -RRB- in the central nervous system .
23238479	0	b-ureidopropionase	20,38	UPB1	40,44	b-ureidopropionase	UPB1	51733	51733	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Contribution of the b-ureidopropionase -LRB- UPB1 -RRB- gene alterations to the development of fluoropyrimidine-related toxicity .
22080612	0	b2-Adrenoceptor	0,15	RGS2	32,36	b2-Adrenoceptor	RGS2	154	5997	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	b2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids .
2652117	0	b2-m	46,50	b2-microglobulin	28,44	b2-m	b2-microglobulin	567	3135	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Intra-renal localization of b2-microglobulin -LRB- b2-m -RRB- in renal transplant material .
2652117	0	b2-microglobulin	28,44	b2-m	46,50	b2-microglobulin	b2-m	3135	567	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Intra-renal localization of b2-microglobulin -LRB- b2-m -RRB- in renal transplant material .
25182705	0	b2-microglobulin	156,172	dendritic_cell-specific_intercellular_adhesion_molecule-3-grabbing_nonintegrin	18,96	b2-microglobulin	dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin	3135	30835	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Low expression of dendritic_cell-specific_intercellular_adhesion_molecule-3-grabbing_nonintegrin in non-Hodgkin_lymphoma and a significant correlation with b2-microglobulin .
21914629	0	b2GPI	112,117	CD4	86,89	b2GPI	CD4	350	920	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Tolerogenic dendritic cells inhibit antiphospholipid_syndrome derived effector/memory CD4 T cell response to b2GPI .
19074839	0	b2_receptor	6,17	cyclooxygenase-2	40,56	b2 receptor	cyclooxygenase-2	624	5743	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Kinin b2_receptor mediates induction of cyclooxygenase-2 and is overexpressed in head_and_neck_squamous_cell_carcinomas .
11178937	0	b42	152,155	janus_kinase_2	115,129	b42	janus kinase 2	108767(Tax:10090)	16452(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	LPS induction of I_kappa_B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus_kinase_2 inhibitor , Tyrphostin b42 .
11295830	0	b5_reductase	147,159	diaphorase_1	161,173	b5 reductase	diaphorase 1	1727	1727	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular basis of recessive_congenital_methemoglobinemia , types I and II : Exon skipping and three novel missense mutations in the NADH-cytochrome b5_reductase -LRB- diaphorase_1 -RRB- gene .
9252460	0	bFGF	0,4	BCK	13,16	bFGF	BCK	14173(Tax:10090)	12709(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	bFGF induces BCK promoter-driven expression in muscle via increased binding of a nuclear protein .
10332154	0	bFGF	55,59	BMP-7	92,97	bFGF	BMP-7	54250(Tax:10116)	85272(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	-LSB- Biological effects of basic fibroblast growth factor -LRB- bFGF -RRB- and osteogenic protein-1 -LRB- OP-1 / BMP-7 -RRB- on bone marrow cells and development of cell-hybrid artificial bone -RSB- .
9747507	0	bFGF	14,18	C1s	42,45	bFGF	C1s	2247	716	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Inhibition of bFGF activity by complement C1s : covalent binding of C1s with bFGF .
9747507	0	bFGF	14,18	C1s	67,70	bFGF	C1s	2247	716	Gene	Gene	activity|compound|START_ENTITY Inhibition|nmod|activity Inhibition|dep|covalent covalent|nmod|END_ENTITY	Inhibition of bFGF activity by complement C1s : covalent binding of C1s with bFGF .
9747507	0	bFGF	76,80	C1s	42,45	bFGF	C1s	2247	716	Gene	Gene	C1s|nmod|START_ENTITY covalent|nmod|C1s Inhibition|dep|covalent Inhibition|nmod|activity activity|nmod|END_ENTITY	Inhibition of bFGF activity by complement C1s : covalent binding of C1s with bFGF .
23346166	0	bFGF	10,14	CD24	52,56	bFGF	CD24	2247	100133941	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of bFGF on the MCF-7 Cell Cycle with CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- : Promoting the G0/G1 > G2/S Transition .
25328292	0	bFGF	75,79	CD34	34,38	bFGF	CD34	2247	947	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of CD34 and basic_fibroblast_growth_factor -LRB- bFGF -RRB- in oral_submucous_fibrosis .
23346166	0	bFGF	10,14	CD44	44,48	bFGF	CD44	2247	960	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bFGF on the MCF-7 Cell Cycle with CD44 -LRB- + -RRB- / CD24 -LRB- - -RRB- : Promoting the G0/G1 > G2/S Transition .
17211450	0	bFGF	25,29	ERK	38,41	bFGF	ERK	14173(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation .
22715588	0	bFGF	55,59	ERK	94,97	bFGF	ERK	2247	5594	Gene	Gene	basic_fibroblast_growth_factor|appos|START_ENTITY basic_fibroblast_growth_factor|dep|angiogenesis angiogenesis|acl|blocking blocking|dobj|activation activation|compound|END_ENTITY	Coenzyme_Q10 decreases basic_fibroblast_growth_factor -LRB- bFGF -RRB- - induced angiogenesis by blocking ERK activation .
15985216	0	bFGF	25,29	Endostatin	0,10	bFGF	Endostatin	2247	80781	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans .
8375342	0	bFGF	32,36	FGF-2	25,30	bFGF	FGF-2	396413(Tax:9031)	396413(Tax:9031)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Retroviral expression of FGF-2 -LRB- bFGF -RRB- affects patterning in chick limb bud .
11124896	0	bFGF	0,4	GAP-43	16,22	bFGF	GAP-43	2247	2596	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	bFGF stimulates GAP-43 phosphorylation at ser41 and modifies its intracellular localization in cultured hippocampal neurons .
11478488	0	bFGF	85,89	HER2/Neu	32,40	bFGF	HER2/Neu	2247	2064	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF , TGF-beta , and PDGF in bile from biliary malignancies and inflammatory_disorders .
11962191	0	bFGF	114,118	IGF-1	71,76	bFGF	IGF-1	54250(Tax:10116)	24482(Tax:10116)	Gene	Gene	insulin-like_growth_factor_1|appos|START_ENTITY insulin-like_growth_factor_1|appos|END_ENTITY	-LSB- Experimental data for administration of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- for prevention of radiation_myelopathy -RSB- .
21551900	0	bFGF	107,111	IGF-I	64,69	bFGF	IGF-I	54250(Tax:10116)	24482(Tax:10116)	Gene	Gene	insulin-like_growth_factor_I|appos|START_ENTITY insulin-like_growth_factor_I|appos|END_ENTITY	Nerve regeneration is improved by insulin-like_growth_factor_I -LRB- IGF-I -RRB- and basic_flbroblast_growth_factor -LRB- bFGF -RRB- .
8745211	0	bFGF	39,43	IGF-I	77,82	bFGF	IGF-I	54250(Tax:10116)	24482(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	Influence of fibroblast growth factor -LRB- bFGF -RRB- and insulin-like growth factor -LRB- IGF-I -RRB- on cytoskeletal and contractile structures and on atrial_natriuretic_factor -LRB- ANF -RRB- expression in adult rat ventricular cardiomyocytes in culture .
15781321	0	bFGF	36,40	MMP-2	45,50	bFGF	MMP-2	2247	4313	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of basic fibroblast factor -LRB- bFGF -RRB- on MMP-2 , TIMP-2 , and type-I collagen levels in human lung_carcinoma fibroblasts .
9400998	0	bFGF	54,58	Mdm2	13,17	bFGF	Mdm2	2247	4193	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of Mdm2 and enhancement of cell survival by bFGF .
18773427	0	bFGF	0,4	S1P1	13,17	bFGF	S1P1	2247	1901	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	bFGF induces S1P1 receptor expression and functionality in human pulmonary artery smooth muscle cells .
21906308	0	bFGF	32,36	STAT3	67,72	bFGF	STAT3	2247	6774	Gene	Gene	RNA|amod|START_ENTITY delivery|nmod|RNA reduces|nsubj|delivery reduces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251 .
8900046	0	bFGF	0,4	STAT3	33,38	bFGF	STAT3	2247	6774	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	bFGF and LIF signaling activates STAT3 in proliferating myoblasts .
1321201	0	bFGF	27,31	TGF-beta	45,53	bFGF	TGF-beta	2247	7040	Gene	Gene	receptors|compound|START_ENTITY modulation|nmod|receptors modulation|nmod|END_ENTITY	Differential modulation of bFGF receptors by TGF-beta in adult skin , scleroderma skin , and newborn foreskin fibroblasts .
10411682	0	bFGF	47,51	TGF-beta1	0,9	bFGF	TGF-beta1	2247	7040	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	TGF-beta1 stimulates the release of pre-formed bFGF from renal proximal tubular cells .
16095497	0	bFGF	31,35	TGF-beta1	21,30	bFGF	TGF-beta1	2247	7040	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Differential role of TGF-beta1 / bFGF and ET-1 in graft fibrosis in heart_failure patients .
16463783	0	bFGF	61,65	TGF-beta1	50,59	bFGF	TGF-beta1	2247	7040	Gene	Gene	procollagen|nsubj|START_ENTITY procollagen|advcl|-LSB- -LSB-|nmod|expression expression|nmod|END_ENTITY	-LSB- The influence of adrenaline on the expression of TGF-beta1 , bFGF and I procollagen for hypertrophic_scar -RSB- .
15714461	0	bFGF	55,59	VEGF	39,43	bFGF	VEGF	2247	7422	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D_breast_cancer cell line under normoxic conditions : involvement of PI-3K / Akt and MEK1/ERK pathways .
16433046	0	bFGF	43,47	VEGF	37,41	bFGF	VEGF	2247	7422	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|levels levels|nmod|END_ENTITY	Changes in maternal plasma levels of VEGF , bFGF , TGF-beta1 , ET-1 and sKL during uncomplicated pregnancy , hypertensive pregnancy_and_gestational_diabetes .
16934908	0	bFGF	38,42	VEGF	23,27	bFGF	VEGF	2247	7422	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Enhanced expression of VEGF following bFGF inhibition in non-small_cell_lung_cancer cell lines .
21176170	0	bFGF	143,147	VEGF	101,105	bFGF	VEGF	2247	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	The impact of hyperbaric oxygen therapy on serological values of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- .
26665394	0	bFGF	27,31	VEGF	33,37	bFGF	VEGF	2247	7422	Gene	Gene	START_ENTITY|appos|SECRETION SECRETION|compound|END_ENTITY	THE EFFECT OF IBUPROFEN ON bFGF , VEGF SECRETION AND CELL PROLIFERATION IN THE PRESENCE OF LPS IN HMEC-1 CELLS .
26712666	0	bFGF	162,166	VEGF	120,124	bFGF	VEGF	2247	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Comparison of invasion by human microvascular endothelial cell lines in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- in a threedimensional -LRB- 3D -RRB- cell culture system .
9677468	0	bFGF	110,114	VEGF	68,72	bFGF	VEGF	2247	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Independent expression of serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- and basic_fibroblast_growth_factor -LRB- bFGF -RRB- in patients with carcinoma and sarcoma .
21459437	0	bFGF	12,16	a-SMA	36,41	bFGF	a-SMA	2247	58	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The role of bFGF in down-regulating a-SMA expression of chondrogenically induced BMSCs and preventing the shrinkage of BMSC engineered cartilage .
23749297	0	bFGF	0,4	alkaline_phosphatase	26,46	bFGF	alkaline phosphatase	2247	250	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|amod|END_ENTITY	bFGF and JAGGED1 regulate alkaline_phosphatase expression and mineralization in dental tissue-derived mesenchymal stem cells .
10455199	1	bFGF	143,147	basic_fibroblast_growth_factor	111,141	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	A mechanism for basic_fibroblast_growth_factor -LRB- bFGF -RRB- release and attenuation of bfgf binding following elastase-induced injury .
10459618	0	bFGF	48,52	basic_fibroblast_growth_factor	16,46	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transfection of basic_fibroblast_growth_factor -LRB- bFGF -RRB- gene or bFGF antisense fene into human retinal pigment epithelial cells .
11032988	0	bFGF	136,140	basic_fibroblast_growth_factor	104,134	bFGF	basic fibroblast growth factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Distinctive amygdala kindled seizures differentially affect neurobehavioral recovery and lesion-induced basic_fibroblast_growth_factor -LRB- bFGF -RRB- expression .
11798934	0	bFGF	47,51	basic_fibroblast_growth_factor	15,45	bFGF	basic fibroblast growth factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in rat and mouse skin and its biological significance -RSB- .
11876901	0	bFGF	107,111	basic_fibroblast_growth_factor	75,105	bFGF	basic fibroblast growth factor	281161(Tax:9913)	281161(Tax:9913)	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- A comparative study on wound healing treated by different doses of bovine basic_fibroblast_growth_factor -LRB- bFGF -RRB- -RSB- .
11876913	0	bFGF	109,113	basic_fibroblast_growth_factor	77,107	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Modulation of the activity of human alpha1 -LRB- I -RRB- procollagen gene promoter by basic_fibroblast_growth_factor -LRB- bFGF -RRB- -RSB- .
12088611	0	bFGF	47,51	basic_fibroblast_growth_factor	15,45	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on the breaking strength of acute incisional wounds .
12630552	0	bFGF	54,58	basic_fibroblast_growth_factor	22,52	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant basic_fibroblast_growth_factor -LRB- bFGF -RRB- on fibroblast-like cells from human rotator cuff tendon .
17619941	0	bFGF	79,83	basic_fibroblast_growth_factor	47,77	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Effects of laser irradiation on the release of basic_fibroblast_growth_factor -LRB- bFGF -RRB- , insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- , and receptor of IGF-1 -LRB- IGFBP3 -RRB- from gingival fibroblasts .
17726742	0	bFGF	42,46	basic_fibroblast_growth_factor	10,40	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on the treatment of exposure of the orbital implants .
19261517	0	bFGF	68,72	basic_fibroblast_growth_factor	36,66	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Immunohistochemical distribution of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in medicolegal autopsy .
2199583	0	bFGF	46,50	basic_fibroblast_growth_factor	14,44	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in Kaposi 's _ sarcoma : an immunohistologic study .
2771166	0	bFGF	43,47	basic_fibroblast_growth_factor	11,41	bFGF	basic fibroblast growth factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on choline_acetyltransferase activity and astroglial reaction in adult rats after partial fimbria transection .
8148157	0	bFGF	68,72	basic_fibroblast_growth_factor	36,66	bFGF	basic fibroblast growth factor	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- within growing and atretic_mouse_ovarian_follicles .
8572647	0	bFGF	58,62	basic_fibroblast_growth_factor	26,56	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Increased serum levels of basic_fibroblast_growth_factor -LRB- bFGF -RRB- are associated with progressive lung metastases in advanced_renal_cell_carcinoma patients .
8814596	0	bFGF	54,58	basic_fibroblast_growth_factor	22,52	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in human periodontal ligament -LRB- PDL -RRB- tissue .
8907576	0	bFGF	63,67	basic_fibroblast_growth_factor	31,61	bFGF	basic fibroblast growth factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in the repair process of rat liver_injury .
9272417	0	bFGF	68,72	basic_fibroblast_growth_factor	36,66	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- during folliculogenesis in the human ovary .
9365172	0	bFGF	46,50	basic_fibroblast_growth_factor	14,44	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Low levels of basic_fibroblast_growth_factor -LRB- bFGF -RRB- are associated with a poor prognosis in human breast_carcinoma .
9387885	0	bFGF	45,49	basic_fibroblast_growth_factor	13,43	bFGF	basic fibroblast growth factor	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of basic_fibroblast_growth_factor -LRB- bFGF -RRB- expression following focal cerebral_ischemia .
9456251	0	bFGF	80,84	basic_fibroblast_growth_factor	48,78	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Inflammatory cytokines induce the expression of basic_fibroblast_growth_factor -LRB- bFGF -RRB- isoforms required for the growth of Kaposi 's _ sarcoma and endothelial cells through the activation of AP-1 response elements in the bFGF promoter .
9556816	0	bFGF	58,62	basic_fibroblast_growth_factor	26,56	bFGF	basic fibroblast growth factor	2247	2247	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant basic_fibroblast_growth_factor -LRB- bFGF -RRB- in fibrin adhesive vehicle on the healing of ischaemic and normal incisional skin wounds .
20432624	0	bFGF	50,54	calcitonin_gene-related_peptide	15,46	bFGF	calcitonin gene-related peptide	54250(Tax:10116)	24241(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	The effects of calcitonin_gene-related_peptide on bFGF and AQP4 expression after focal cerebral_ischemia reperfusion in rats .
27007053	0	bFGF	73,77	fibroblast_growth_factor_2	39,65	bFGF	fibroblast growth factor 2	2247	2247	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Molecular and clinical significance of fibroblast_growth_factor_2 -LRB- FGF2 / bFGF -RRB- in malignancies_of_solid_and_hematological_cancers for personalized therapies .
14555210	0	bFGF	32,36	plasma_membrane_calcium_ATPase	56,86	bFGF	plasma membrane calcium ATPase	2247	491	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Basic_fibroblast_growth_factor -LRB- bFGF -RRB- regulation of the plasma_membrane_calcium_ATPase -LRB- PMCA -RRB- as part of an anti-apoptotic mechanism of action .
21115896	0	bFGF-R	31,37	VEGF-R2	23,30	bFGF-R	VEGF-R2	2260	3791	Gene	Gene	inhibitor|amod|START_ENTITY /|dobj|inhibitor /|nsubj|END_ENTITY	Brivanib , a novel dual VEGF-R2 / bFGF-R inhibitor .
25794933	0	bHLH104	30,37	IAA-LEUCINE_RESISTANT3	53,75	bHLH104	IAA-LEUCINE RESISTANT3	827086(Tax:3702)	835557(Tax:3702)	Gene	Gene	Interacts|compound|START_ENTITY Interacts|nmod|END_ENTITY	The bHLH Transcription Factor bHLH104 Interacts with IAA-LEUCINE_RESISTANT3 and Modulates Iron Homeostasis in Arabidopsis .
22017877	0	bTrCP	60,65	DEPTOR	101,107	bTrCP	DEPTOR	8945	64798	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	mTOR generates an auto-amplification loop by triggering the bTrCP - and CK1a-dependent degradation of DEPTOR .
22017875	0	bTrCP	39,44	SCF	35,38	bTrCP	SCF	8945	4254	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	mTOR drives its own activation via SCF -LRB- bTrCP -RRB- - dependent degradation of the mTOR inhibitor DEPTOR .
26217795	0	bTrCP	73,78	SCF	69,72	bTrCP	SCF	8945	4254	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Datasets from an interaction proteomics screen for substrates of the SCF -LRB- bTrCP -RRB- ubiquitin ligase .
23027877	0	bTrCP	38,43	Skp1-Cul1-F-box	0,15	bTrCP	Skp1-Cul1-F-box	8945	4254;6500	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Skp1-Cul1-F-box ubiquitin ligase -LRB- SCF -LRB- bTrCP -RRB- -RRB- - mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry .
23624714	0	bZIP28	92,98	BINDING_PROTEIN	0,15	bZIP28	BINDING PROTEIN	820249(Tax:3702)	834207(Tax:3702)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	BINDING_PROTEIN is a master regulator of the endoplasmic reticulum stress sensor/transducer bZIP28 in Arabidopsis .
23869562	0	bZIP60	66,72	NAC103	45,51	bZIP60	NAC103	840897(Tax:3702)	836527(Tax:3702)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The plant-specific transcription factor gene NAC103 is induced by bZIP60 through a new cis-regulatory element to modulate the unfolded protein response in Arabidopsis .
15896843	0	bactericidal_permeability-increasing_protein	44,88	BPI	90,93	bactericidal permeability-increasing protein	BPI	100304639(Tax:7998)	100304639(Tax:7998)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Characterization and expression analysis of bactericidal_permeability-increasing_protein -LRB- BPI -RRB- antimicrobial peptide gene from channel_catfish Ictalurus_punctatus .
23742867	0	bactericidal_permeability-increasing_protein	42,86	BPI	88,91	bactericidal permeability-increasing protein	BPI	671	671	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Identification and expression analysis on bactericidal_permeability-increasing_protein -LRB- BPI -RRB- / lipopolysaccharide-binding_protein -LRB- LBP -RRB- of ark shell , Scapharca broughtonii .
26815504	0	baculoviral_IAP_repeat-containing_3	63,98	BIRC3	100,105	baculoviral IAP repeat-containing 3	BIRC3	330	330	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SHh-Gli1 signaling pathway promotes cell survival by mediating baculoviral_IAP_repeat-containing_3 -LRB- BIRC3 -RRB- gene in pancreatic_cancer cells .
21393385	0	bad	84,87	Bcl-2	119,124	bad	Bcl-2	572	596	Gene	Gene	START_ENTITY|appos|protein protein|nmod|family family|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
21393385	0	bad	84,87	Bcl-2	4,9	bad	Bcl-2	572	596	Gene	Gene	regulation|nmod|START_ENTITY reveals|dobj|regulation reveals|nsubj|domain domain|compound|END_ENTITY	The Bcl-2 homology domain 3 -LRB- BH3 -RRB- mimetic ABT-737 reveals the dynamic regulation of bad , a proapoptotic protein of the Bcl-2 family , by Bcl-xL .
10674827	0	bad	51,54	bcl-2	26,31	bad	bcl-2	572	596	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Expression pattern of the bcl-2 homologous protein bad in normal skin , psoriasis_vulgaris_and_keratinocytic_tumors .
15190125	0	bad	87,90	phosphatidylinositol_3-kinase	95,124	bad	phosphatidylinositol 3-kinase	64639(Tax:10116)	298947(Tax:10116)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	The bile_acid tauroursodeoxycholic_acid modulates phosphorylation and translocation of bad via phosphatidylinositol_3-kinase in glutamate-induced apoptosis of rat cortical neurons .
9013932	0	bagpipe	35,42	Xbap	0,4	bagpipe	Xbap	42537(Tax:7227)	378569(Tax:8355)	Gene	Gene	related|nmod|START_ENTITY gene|acl|related END_ENTITY|appos|gene	Xbap , a vertebrate gene related to bagpipe , is expressed in developing craniofacial structures and in anterior gut muscle .
19139629	0	bak	7,10	Bax	0,3	bak	Bax	578	581	Gene	Gene	/|parataxis|START_ENTITY END_ENTITY|dep|/	Bax - / - bak - / - cells exhibit p27 Thr198 phosphorylation and autophagy .
24014020	0	barrier_to_autointegration_factor	70,103	emerin	52,58	barrier to autointegration factor	emerin	8815	2010	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	O-Linked b-N-acetylglucosamine -LRB- O-GlcNAc -RRB- regulates emerin binding to barrier_to_autointegration_factor -LRB- BAF -RRB- in a chromatin - and lamin B-enriched `` niche '' .
12145299	0	bas1	114,118	pho4	120,124	bas1	pho4	853974(Tax:4932)	850594(Tax:4932)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Mutations in the pho2 -LRB- bas2 -RRB- transcription factor that differentially affect activation with its partner proteins bas1 , pho4 , and swi5 .
12145299	0	bas2	23,27	pho2	17,21	bas2	pho2	851452(Tax:4932)	851452(Tax:4932)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Mutations in the pho2 -LRB- bas2 -RRB- transcription factor that differentially affect activation with its partner proteins bas1 , pho4 , and swi5 .
10728810	0	basal_cell_adhesion_molecule	18,46	B-CAM	48,53	basal cell adhesion molecule	B-CAM	4059	4059	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the basal_cell_adhesion_molecule -LRB- B-CAM -RRB- in normal and diseased human skin .
16634529	0	basic-fibroblast_growth_factor	12,42	b-FGF	44,49	basic-fibroblast growth factor	b-FGF	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of basic-fibroblast_growth_factor -LRB- b-FGF -RRB- in cyclosporine-induced nephrotoxicity .
22895673	0	basic_Fibroblast_Growth_Factor	22,52	FGF-2	54,59	basic Fibroblast Growth Factor	FGF-2	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dynamic modulation of basic_Fibroblast_Growth_Factor -LRB- FGF-2 -RRB- expression in the rat brain following repeated exposure to cocaine during adolescence .
18605443	0	basic_fibroblast_growth_factor	12,42	ACC-2	117,122	basic fibroblast growth factor	ACC-2	2247	597	Gene	Gene	Effects|nmod|START_ENTITY Effects|amod|END_ENTITY	-LSB- Effects of basic_fibroblast_growth_factor on the proliferation of human salivary adenoid_cystic_carcinoma cell line ACC-2 and extracellular_signal-regulated_kinase , Cyclin_D1 , p2waf/cip1 signaling pathway -RSB- .
11380405	0	basic_fibroblast_growth_factor	50,80	Bcl-2	0,5	basic fibroblast growth factor	Bcl-2	2247	596	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|amod|END_ENTITY	Bcl-2 expression correlates positively with serum basic_fibroblast_growth_factor -LRB- bFGF -RRB- and negatively with cellular vascular_endothelial_growth_factor -LRB- VEGF -RRB- in patients with chronic_lymphocytic_leukaemia .
22932066	0	basic_fibroblast_growth_factor	51,81	CREB	110,114	basic fibroblast growth factor	CREB	54250(Tax:10116)	81646(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Different signal transduction pathways elicited by basic_fibroblast_growth_factor and interleukin_1b regulate CREB phosphorylation in Sertoli cells .
18605443	0	basic_fibroblast_growth_factor	12,42	Cyclin_D1	166,175	basic fibroblast growth factor	Cyclin D1	2247	595	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of basic_fibroblast_growth_factor on the proliferation of human salivary adenoid_cystic_carcinoma cell line ACC-2 and extracellular_signal-regulated_kinase , Cyclin_D1 , p2waf/cip1 signaling pathway -RSB- .
8702507	0	basic_fibroblast_growth_factor	16,46	Egr-1	0,5	basic fibroblast growth factor	Egr-1	2247	1958	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Egr-1 activates basic_fibroblast_growth_factor transcription .
9274456	0	basic_fibroblast_growth_factor	20,50	FGFR-1	69,75	basic fibroblast growth factor	FGFR-1	2247	2260	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of basic_fibroblast_growth_factor and its receptor -LRB- FGFR-1 -RRB- in patients with non-small_cell_lung_carcinomas .
26327163	0	basic_fibroblast_growth_factor	93,123	GLAST	83,88	basic fibroblast growth factor	GLAST	54250(Tax:10116)	29483(Tax:10116)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Stimulation of a7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic_fibroblast_growth_factor production in cultured cortical microglia .
9324017	0	basic_fibroblast_growth_factor	48,78	HOX4C	34,39	basic fibroblast growth factor	HOX4C	2247	3235	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the HOX4C gene by basic_fibroblast_growth_factor on rheumatoid synovial fibroblasts .
8756643	0	basic_fibroblast_growth_factor	31,61	HOXB7	0,5	basic fibroblast growth factor	HOXB7	2247	3217	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	HOXB7 constitutively activates basic_fibroblast_growth_factor in melanomas .
23106660	0	basic_fibroblast_growth_factor	24,54	Interleukin-25	0,14	basic fibroblast growth factor	Interleukin-25	2247	64806	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Interleukin-25 promotes basic_fibroblast_growth_factor expression by human endothelial cells through interaction with IL-17RB , but not IL-17RA .
7768993	0	basic_fibroblast_growth_factor	95,125	MG-160	0,6	basic fibroblast growth factor	MG-160	54250(Tax:10116)	875275(Tax:243273)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MG-160 , a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus , binds basic_fibroblast_growth_factor and exhibits a high level of sequence identity to a chicken fibroblast growth factor receptor .
8725173	0	basic_fibroblast_growth_factor	44,74	NFIL-6	14,20	basic fibroblast growth factor	NFIL-6	14173(Tax:10090)	12608(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of NFIL-6 and IL-6 expression by basic_fibroblast_growth_factor in osteoblasts .
9133674	0	basic_fibroblast_growth_factor	21,51	Oncostatin_M	0,12	basic fibroblast growth factor	Oncostatin M	281161(Tax:9913)	5008	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Oncostatin_M induces basic_fibroblast_growth_factor expression in endothelial cells and promotes endothelial cell proliferation , migration and spindle morphology .
8040268	0	basic_fibroblast_growth_factor	54,84	Platelet_factor_4	0,17	basic fibroblast growth factor	Platelet factor 4	2247	5196	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Platelet_factor_4 modulates the mitogenic activity of basic_fibroblast_growth_factor .
15143181	0	basic_fibroblast_growth_factor	74,104	RAGE	119,123	basic fibroblast growth factor	RAGE	54250(Tax:10116)	81722(Tax:10116)	Gene	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic_fibroblast_growth_factor and S100B via RAGE binding .
16289960	0	basic_fibroblast_growth_factor	32,62	VEGF	125,129	basic fibroblast growth factor	VEGF	2247	7422	Gene	Gene	neuropilin-1|nmod|START_ENTITY Upregulation|nmod|neuropilin-1 enhances|nsubj|Upregulation enhances|xcomp|vascular vascular|nmod|END_ENTITY	Upregulation of neuropilin-1 by basic_fibroblast_growth_factor enhances vascular smooth muscle cell migration in response to VEGF .
9808152	0	basic_fibroblast_growth_factor	60,90	VEGF	36,40	basic fibroblast growth factor	VEGF	281161(Tax:9913)	281572(Tax:9913)	Gene	Gene	synergizes|nmod|START_ENTITY Vascular_endothelial_growth_factor|dep|synergizes Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - C synergizes with basic_fibroblast_growth_factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity .
9808152	0	basic_fibroblast_growth_factor	60,90	Vascular_endothelial_growth_factor	0,34	basic fibroblast growth factor	Vascular endothelial growth factor	281161(Tax:9913)	281572(Tax:9913)	Gene	Gene	synergizes|nmod|START_ENTITY END_ENTITY|dep|synergizes	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - C synergizes with basic_fibroblast_growth_factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity .
18556781	0	basic_fibroblast_growth_factor	101,131	YKL-40	0,6	basic fibroblast growth factor	YKL-40	2247	1116	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	YKL-40 , a marker of simian_immunodeficiency_virus encephalitis , modulates the biological activity of basic_fibroblast_growth_factor .
10455199	1	basic_fibroblast_growth_factor	111,141	bFGF	143,147	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	A mechanism for basic_fibroblast_growth_factor -LRB- bFGF -RRB- release and attenuation of bfgf binding following elastase-induced injury .
10459618	0	basic_fibroblast_growth_factor	16,46	bFGF	48,52	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transfection of basic_fibroblast_growth_factor -LRB- bFGF -RRB- gene or bFGF antisense fene into human retinal pigment epithelial cells .
11032988	0	basic_fibroblast_growth_factor	104,134	bFGF	136,140	basic fibroblast growth factor	bFGF	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Distinctive amygdala kindled seizures differentially affect neurobehavioral recovery and lesion-induced basic_fibroblast_growth_factor -LRB- bFGF -RRB- expression .
11798934	0	basic_fibroblast_growth_factor	15,45	bFGF	47,51	basic fibroblast growth factor	bFGF	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in rat and mouse skin and its biological significance -RSB- .
11876901	0	basic_fibroblast_growth_factor	75,105	bFGF	107,111	basic fibroblast growth factor	bFGF	281161(Tax:9913)	281161(Tax:9913)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- A comparative study on wound healing treated by different doses of bovine basic_fibroblast_growth_factor -LRB- bFGF -RRB- -RSB- .
11876913	0	basic_fibroblast_growth_factor	77,107	bFGF	109,113	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Modulation of the activity of human alpha1 -LRB- I -RRB- procollagen gene promoter by basic_fibroblast_growth_factor -LRB- bFGF -RRB- -RSB- .
12088611	0	basic_fibroblast_growth_factor	15,45	bFGF	47,51	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on the breaking strength of acute incisional wounds .
12630552	0	basic_fibroblast_growth_factor	22,52	bFGF	54,58	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of recombinant basic_fibroblast_growth_factor -LRB- bFGF -RRB- on fibroblast-like cells from human rotator cuff tendon .
17619941	0	basic_fibroblast_growth_factor	47,77	bFGF	79,83	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Effects of laser irradiation on the release of basic_fibroblast_growth_factor -LRB- bFGF -RRB- , insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- , and receptor of IGF-1 -LRB- IGFBP3 -RRB- from gingival fibroblasts .
17726742	0	basic_fibroblast_growth_factor	10,40	bFGF	42,46	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on the treatment of exposure of the orbital implants .
19261517	0	basic_fibroblast_growth_factor	36,66	bFGF	68,72	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Immunohistochemical distribution of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in medicolegal autopsy .
2199583	0	basic_fibroblast_growth_factor	14,44	bFGF	46,50	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in Kaposi 's _ sarcoma : an immunohistologic study .
2771166	0	basic_fibroblast_growth_factor	11,41	bFGF	43,47	basic fibroblast growth factor	bFGF	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on choline_acetyltransferase activity and astroglial reaction in adult rats after partial fimbria transection .
8148157	0	basic_fibroblast_growth_factor	36,66	bFGF	68,72	basic fibroblast growth factor	bFGF	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- within growing and atretic_mouse_ovarian_follicles .
8572647	0	basic_fibroblast_growth_factor	26,56	bFGF	58,62	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Increased serum levels of basic_fibroblast_growth_factor -LRB- bFGF -RRB- are associated with progressive lung metastases in advanced_renal_cell_carcinoma patients .
8814596	0	basic_fibroblast_growth_factor	22,52	bFGF	54,58	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in human periodontal ligament -LRB- PDL -RRB- tissue .
8907576	0	basic_fibroblast_growth_factor	31,61	bFGF	63,67	basic fibroblast growth factor	bFGF	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- in the repair process of rat liver_injury .
9272417	0	basic_fibroblast_growth_factor	36,66	bFGF	68,72	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of basic_fibroblast_growth_factor -LRB- bFGF -RRB- during folliculogenesis in the human ovary .
9365172	0	basic_fibroblast_growth_factor	14,44	bFGF	46,50	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Low levels of basic_fibroblast_growth_factor -LRB- bFGF -RRB- are associated with a poor prognosis in human breast_carcinoma .
9387885	0	basic_fibroblast_growth_factor	13,43	bFGF	45,49	basic fibroblast growth factor	bFGF	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of basic_fibroblast_growth_factor -LRB- bFGF -RRB- expression following focal cerebral_ischemia .
9456251	0	basic_fibroblast_growth_factor	48,78	bFGF	80,84	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Inflammatory cytokines induce the expression of basic_fibroblast_growth_factor -LRB- bFGF -RRB- isoforms required for the growth of Kaposi 's _ sarcoma and endothelial cells through the activation of AP-1 response elements in the bFGF promoter .
9556816	0	basic_fibroblast_growth_factor	26,56	bFGF	58,62	basic fibroblast growth factor	bFGF	2247	2247	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of recombinant basic_fibroblast_growth_factor -LRB- bFGF -RRB- in fibrin adhesive vehicle on the healing of ischaemic and normal incisional skin wounds .
21597045	0	basic_fibroblast_growth_factor	18,48	basic_fibroblast_growth_factor	70,100	basic fibroblast growth factor	basic fibroblast growth factor	2247	2247	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of serum basic_fibroblast_growth_factor , estradiol and urine basic_fibroblast_growth_factor in differentiating infantile haemangiomas from vascular_malformations .
21597045	0	basic_fibroblast_growth_factor	70,100	basic_fibroblast_growth_factor	18,48	basic fibroblast growth factor	basic fibroblast growth factor	2247	2247	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of serum basic_fibroblast_growth_factor , estradiol and urine basic_fibroblast_growth_factor in differentiating infantile haemangiomas from vascular_malformations .
20079000	0	basic_fibroblast_growth_factor	11,41	bone_morphogenetic_protein_4	79,107	basic fibroblast growth factor	bone morphogenetic protein 4	54250(Tax:10116)	25296(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of basic_fibroblast_growth_factor on expression of protein and mRNA of bone_morphogenetic_protein_4 in hypoxic-ischemic_brain_damage in newborn rats -RSB- .
1332847	0	basic_fibroblast_growth_factor	97,127	c-fos	169,174	basic fibroblast growth factor	c-fos	54250(Tax:10116)	314322(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY synthesis|nmod|cells regulation|nmod|synthesis regulation|dep|correlation correlation|nmod|regulation regulation|nmod|END_ENTITY	Opposite regulation of deoxyribonucleic_acid synthesis and iodide uptake in rat thyroid cells by basic_fibroblast_growth_factor : correlation with opposite regulation of c-fos and thyrotropin receptor gene expression .
7707864	0	basic_fibroblast_growth_factor	78,108	c-fos	14,19	basic fibroblast growth factor	c-fos	54250(Tax:10116)	314322(Tax:10116)	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|Expression Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of c-fos mRNA after cortical ablation in rat brain is modulated by basic_fibroblast_growth_factor -LRB- bFGF -RRB- and the NMDA receptor is involved in c-fos expression .
7964901	0	basic_fibroblast_growth_factor	105,135	c-fos	0,5	basic fibroblast growth factor	c-fos	54250(Tax:10116)	314322(Tax:10116)	Gene	Gene	immunoreactivity|compound|START_ENTITY correlated|nmod|immunoreactivity expression|acl|correlated expression|amod|END_ENTITY	c-fos protein expression and ischemic changes in neurons vulnerable to ischemia/hypoxia , correlated with basic_fibroblast_growth_factor immunoreactivity .
9151769	0	basic_fibroblast_growth_factor	14,44	c-fos	112,117	basic fibroblast growth factor	c-fos	2247	2353	Gene	Gene	mRNA|compound|START_ENTITY Expression|nmod|mRNA Expression|dep|comparison comparison|nmod|expression expression|nmod|END_ENTITY	Expression of basic_fibroblast_growth_factor mRNA after transient focal ischemia : comparison with expression of c-fos , c-jun , and hsp_70 mRNA .
9501868	0	basic_fibroblast_growth_factor	48,78	c-fos	13,18	basic fibroblast growth factor	c-fos	54250(Tax:10116)	314322(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of c-fos and c-jun mRNA expression by basic_fibroblast_growth_factor in cultured rat M ller cells .
2771166	0	basic_fibroblast_growth_factor	11,41	choline_acetyltransferase	52,77	basic fibroblast growth factor	choline acetyltransferase	54250(Tax:10116)	290567(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on choline_acetyltransferase activity and astroglial reaction in adult rats after partial fimbria transection .
19277979	0	basic_fibroblast_growth_factor	65,95	connective_tissue_growth_factor	8,39	basic fibroblast growth factor	connective tissue growth factor	14173(Tax:10090)	14219(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of connective_tissue_growth_factor and its interaction with basic_fibroblast_growth_factor and macrophage_chemoattractant_protein-1 in skin fibrosis .
10067868	0	basic_fibroblast_growth_factor	95,125	endothelial_nitric_oxide_synthase	180,213	basic fibroblast growth factor	endothelial nitric oxide synthase	2247	4846	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of the mitogen-activated protein kinase cascade is necessary but not sufficient for basic_fibroblast_growth_factor - and epidermal_growth_factor-stimulated expression of endothelial_nitric_oxide_synthase in ovine fetoplacental artery endothelial cells .
19637492	0	basic_fibroblast_growth_factor	11,41	epidermal_growth_factor_receptor	68,100	basic fibroblast growth factor	epidermal growth factor receptor	2247	1956	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of basic_fibroblast_growth_factor on the gene expression of epidermal_growth_factor_receptor by periodontal ligament cells in culture -RSB- .
8425916	0	basic_fibroblast_growth_factor	54,84	epidermal_growth_factor_receptor	18,50	basic fibroblast growth factor	epidermal growth factor receptor	54250(Tax:10116)	24329(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of the epidermal_growth_factor_receptor by basic_fibroblast_growth_factor .
9516457	0	basic_fibroblast_growth_factor	11,41	fibrinogen	45,55	basic fibroblast growth factor	fibrinogen	2247	2244	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of basic_fibroblast_growth_factor to fibrinogen and fibrin .
15769312	0	basic_fibroblast_growth_factor	10,40	glial_fibrillary_acidic_protein	62,93	basic fibroblast growth factor	glial fibrillary acidic protein	54250(Tax:10116)	24387(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of basic_fibroblast_growth_factor on the expression of glial_fibrillary_acidic_protein after tractive spinal_cord_injury in rats .
15924676	0	basic_fibroblast_growth_factor	62,92	glucose_transporter-1	15,36	basic fibroblast growth factor	glucose transporter-1	2247	6513	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of glucose_transporter-1 and its correlation with basic_fibroblast_growth_factor and proliferating_cell_nuclear_antigen in epithelial_ovarian_neoplasm -RSB- .
12010641	0	basic_fibroblast_growth_factor	134,164	glucose_transporter_1	69,90	basic fibroblast growth factor	glucose transporter 1	54250(Tax:10116)	24778(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Regulation of lactate production and glucose transport as well as of glucose_transporter_1 and lactate_dehydrogenase_A mRNA levels by basic_fibroblast_growth_factor in rat Sertoli cells .
1621612	0	basic_fibroblast_growth_factor	51,81	hEGF	44,48	basic fibroblast growth factor	hEGF	2247	1950	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	-LSB- Presence of human epidermal growth factor -LRB- hEGF -RRB- , basic_fibroblast_growth_factor -LRB- bFGF -RRB- in human aqueous -RSB- .
17619941	0	basic_fibroblast_growth_factor	47,77	insulin_like_growth_factor-1	86,114	basic fibroblast growth factor	insulin like growth factor-1	2247	3479	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Effects of laser irradiation on the release of basic_fibroblast_growth_factor -LRB- bFGF -RRB- , insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- , and receptor of IGF-1 -LRB- IGFBP3 -RRB- from gingival fibroblasts .
18403889	0	basic_fibroblast_growth_factor	63,93	interleukin-1alpha	11,29	basic fibroblast growth factor	interleukin-1alpha	2247	3552	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effects of interleukin-1alpha on the production and release of basic_fibroblast_growth_factor in cultured nifedipine-reactive gingival fibroblasts .
9710742	0	basic_fibroblast_growth_factor	68,98	multidrug_resistance-associated_protein	19,58	basic fibroblast growth factor	multidrug resistance-associated protein	2247	8714	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	A possible role of multidrug_resistance-associated_protein -LRB- MRP -RRB- in basic_fibroblast_growth_factor secretion by AIDS-associated Kaposi 's _ sarcoma cells : a survival molecule ?
9824653	0	basic_fibroblast_growth_factor	80,110	multidrug_resistance-associated_protein	20,59	basic fibroblast growth factor	multidrug resistance-associated protein	2247	8714	Gene	Gene	secretion|nmod|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	A possible role for multidrug_resistance-associated_protein in the secretion of basic_fibroblast_growth_factor by osteogenic_sarcoma cell line -LRB- MG-63 -RRB- .
1280364	0	basic_fibroblast_growth_factor	10,40	ornithine_decarboxylase	44,67	basic fibroblast growth factor	ornithine decarboxylase	54250(Tax:10116)	24609(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of basic_fibroblast_growth_factor on ornithine_decarboxylase activity and mRNA expression in a pancreatic tumoral cell line -LRB- AR4-2J -RRB- .
8344959	0	basic_fibroblast_growth_factor	54,84	syndecan_3	12,22	basic fibroblast growth factor	syndecan 3	54250(Tax:10116)	116673(Tax:10116)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	N-syndecan -LRB- syndecan_3 -RRB- from neonatal rat brain binds basic_fibroblast_growth_factor .
11767002	0	basic_fibroblast_growth_factor	97,127	transforming_growth_factor_beta	8,39	basic fibroblast growth factor	transforming growth factor beta	2247	7040	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of transforming_growth_factor_beta in the growth inhibition of human breast_cancer cells by basic_fibroblast_growth_factor .
8054359	1	basic_fibroblast_growth_factor	220,250	tumor_necrosis_factor_alpha	142,169	basic fibroblast growth factor	tumor necrosis factor alpha	2247	7124	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation by tumor_necrosis_factor_alpha and up-regulation by transforming_growth_factor-B basic_fibroblast_growth_factor .
7860647	0	basic_fibroblast_growth_factor	126,156	urokinase-type_plasminogen_activator	54,90	basic fibroblast growth factor	urokinase-type plasminogen activator	281161(Tax:9913)	281408(Tax:9913)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional and posttranscriptional regulation of urokinase-type_plasminogen_activator expression in endothelial cells by basic_fibroblast_growth_factor .
11479208	0	basic_fibroblast_growth_factor	88,118	vascular_endothelial_growth_factor	37,71	basic fibroblast growth factor	vascular endothelial growth factor	2247	7422	Gene	Gene	independent|nmod|START_ENTITY up-regulation|appos|independent up-regulation|nmod|END_ENTITY	HIF-1alpha-mediated up-regulation of vascular_endothelial_growth_factor , independent of basic_fibroblast_growth_factor , is important in the switch to the angiogenic phenotype during early tumorigenesis .
11774282	0	basic_fibroblast_growth_factor	105,135	vascular_endothelial_growth_factor	30,64	basic fibroblast growth factor	vascular endothelial growth factor	2247	7422	Gene	Gene	induce|ccomp|START_ENTITY END_ENTITY|xcomp|induce	Human chondrosarcoma secretes vascular_endothelial_growth_factor to induce tumor angiogenesis and stores basic_fibroblast_growth_factor for regulation of its own growth .
25271020	0	basic_fibroblast_growth_factor	70,100	vascular_endothelial_growth_factor	35,69	basic fibroblast growth factor	vascular endothelial growth factor	14173(Tax:10090)	22339(Tax:10090)	Gene	Gene	complex|compound|START_ENTITY peptide|nsubj|complex production|parataxis|peptide production|nmod|END_ENTITY	Soluble production and function of vascular_endothelial_growth_factor / basic_fibroblast_growth_factor complex peptide .
8636009	0	basic_fibroblast_growth_factor	127,157	vascular_endothelial_growth_factor	92,126	basic fibroblast growth factor	vascular endothelial growth factor	2247	7422	Gene	Gene	/|amod|START_ENTITY /|compound|END_ENTITY	Dual pathways of tubular morphogenesis of vascular endothelial cells by human glioma cells : vascular_endothelial_growth_factor / basic_fibroblast_growth_factor and interleukin-8 .
7566486	0	basic_fibroblast_growth_factor	42,72	zif/268	15,22	basic fibroblast growth factor	zif/268	54250(Tax:10116)	24330(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of zif/268 gene expression by basic_fibroblast_growth_factor in primary rat striatal cultures .
18045867	0	basic_transcription_element-binding_protein_1	11,56	BTEB1	58,63	basic transcription element-binding protein 1	BTEB1	373598(Tax:8355)	373598(Tax:8355)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for basic_transcription_element-binding_protein_1 -LRB- BTEB1 -RRB- in the autoinduction of thyroid_hormone_receptor_beta .
23029305	0	basic_transcription_factor_3	71,99	BTF3	101,105	basic transcription factor 3	BTF3	689	689	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human beta casein fragment -LRB- 54-59 -RRB- modulates M. bovis BCG survival and basic_transcription_factor_3 -LRB- BTF3 -RRB- expression in THP-1 cell line .
10363969	0	bax	34,37	Bcl-2	8,13	bax	Bcl-2	581	596	Gene	Gene	loss|compound|START_ENTITY potent|nmod|loss potent|nsubj|Gain Gain|nmod|END_ENTITY	Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo .
17326408	0	bax	58,61	Bcl-2	51,56	bax	Bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	-LSB- Effect of weiganli on apoptosis and expression of Bcl-2 , bax protein in bone marrow nucleated cells of anemic mice -RSB- .
8608975	0	bax	6,9	Bcl-2	0,5	bax	Bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Bcl-2 / bax mRNA expression ratio as prognostic factor in low-grade urinary_bladder_cancer .
8922409	0	bax	80,83	Bcl-2	58,63	bax	Bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Amyloid beta peptide of Alzheimer 's _ disease downregulates Bcl-2 and upregulates bax expression in human neurons .
16319448	0	bax	29,32	Erythropoietin	0,14	bax	Erythropoietin	24887(Tax:10116)	24335(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Erythropoietin downregulates bax and DP5 proapoptotic gene expression in neonatal hypoxic-ischemic_brain_injury .
20054800	0	bax	10,13	P21	0,3	bax	P21	581	644914	Gene	Gene	pathways|compound|START_ENTITY END_ENTITY|appos|pathways	P21 , p27 , bax , cathepsin and survivin pathways in macular_dystrophy corneas .
11451553	0	bax	45,48	PCNA	55,59	bax	PCNA	581	5111	Gene	Gene	p53|dep|START_ENTITY p53|dep|MI MI|compound|END_ENTITY	The importance of biological factors -LRB- bcl-2 , bax , p53 , PCNA , MI , HPV and angiogenesis -RRB- in invasive cervical_cancer .
10492046	0	bax	64,67	bcl-2	58,63	bax	bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Oral_squamous_cell_carcinoma is associated with decreased bcl-2 / bax expression ratio and increased apoptosis .
11078910	0	bax	120,123	bcl-2	114,119	bax	bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Differential sensitivity of MCF-7 and LCC2 cells , to multiple growth inhibitory agents : possible relation to high bcl-2 / bax ratio ?
11592113	0	bax	103,106	bcl-2	96,101	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	caspase-3|dep|START_ENTITY caspase-3|compound|END_ENTITY	Domoic_acid-induced neuronal_damage in the rat hippocampus : changes in apoptosis related genes -LRB- bcl-2 , bax , caspase-3 -RRB- and microglial response .
11759059	0	bax	6,9	bcl-2	0,5	bax	bcl-2	581	596	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	bcl-2 / bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal_cancer .
11860909	0	bax	67,70	bcl-2	60,65	bax	bcl-2	100730890	100733337	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	-LSB- Effects of excessive iodine on apoptosis and expression of bcl-2 , bax genes in the cells of brain and thyroid gland in guinea_pigs -RSB- .
12210599	0	bax	23,26	bcl-2	17,22	bax	bcl-2	581	596	Gene	Gene	Image|dep|START_ENTITY Image|amod|END_ENTITY	Image cytometric bcl-2 : bax and bcl-2 : bcl-x ratios in invasive breast_carcinoma : correlation with prognosis .
12230942	0	bax	61,64	bcl-2	66,71	bax	bcl-2	581	596	Gene	Gene	Effects|appos|START_ENTITY Effects|appos|expression expression|amod|END_ENTITY	Effects of dl-praeruptorin_A on interleukin-6 level and Fas , bax , bcl-2 protein expression in ischemia-reperfusion myocardium .
12373145	0	bax	58,61	bcl-2	51,56	bax	bcl-2	581	596	Gene	Gene	bcl-x|dep|START_ENTITY bcl-x|compound|END_ENTITY	Hepatocellular_carcinoma and markers of apoptosis -LRB- bcl-2 , bax , bcl-x -RRB- : prognostic significance .
12525523	0	bax	17,20	bcl-2	10,15	bax	bcl-2	581	596	Gene	Gene	START_ENTITY|nsubj|Survivin Survivin|amod|END_ENTITY	Survivin , bcl-2 , bax , and bcl-X gene expression in sentinel lymph nodes from melanoma patients .
12934349	0	bax	57,60	bcl-2	50,55	bax	bcl-2	100355675(Tax:9986)	100009447(Tax:9986)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	-LSB- Effect of ischemic preconditioning on myocardial bcl-2 , bax , p53 gene expression during ischemia/reperfusion period in rabbits -RSB- .
14741615	0	bax	45,48	bcl-2	38,43	bax	bcl-2	581	596	Gene	Gene	caspase-3|amod|START_ENTITY caspase-3|amod|END_ENTITY	Effect of cobalt and chromium ions on bcl-2 , bax , caspase-3 , and caspase-8 expression in human U937 macrophages .
15655830	0	bax	97,100	bcl-2	91,96	bax	bcl-2	581	596	Gene	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|expression expression|nmod|/ /|amod|END_ENTITY	Correlation between expression of gastrin , somatostatin and cell apoptosis regulation gene bcl-2 / bax in large intestine carcinoma .
15719136	0	bax	23,26	bcl-2	16,21	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- The changes of bcl-2 , bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats -RSB- .
15973073	0	bax	50,53	bcl-2	35,40	bax	bcl-2	581	596	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
16339882	0	bax	35,38	bcl-2	40,45	bax	bcl-2	581	596	Gene	Gene	roles|nmod|START_ENTITY apoptosis|dep|roles pores|nmod|apoptosis pores|nsubj|transition transition|amod|permeability permeability|dep|END_ENTITY	Bistability in apoptosis : roles of bax , bcl-2 , and mitochondrial permeability transition pores .
16759520	0	bax	71,74	bcl-2	65,70	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	-LSB- Beneficial effects of carvedilol on cardiomyocyte apoptosis and bcl-2 / bax expression after acute_myocardial_infarction an experiment with rats -RSB- .
18683683	0	bax	16,19	bcl-2	10,15	bax	bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	-LSB- Roles of bcl-2 / bax expression and oligodendrocyte apoptosis in the pathogenesis of heroin-induced spongiform_leucoencephalopathy -RSB- .
18928588	0	bax	92,95	bcl-2	86,91	bax	bcl-2	581	596	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Relationship between apoptotic effect of Resveratrol on KG-1 cells and expression of bcl-2 / bax -RSB- .
20021825	0	bax	66,69	bcl-2	60,65	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	genes|compound|START_ENTITY Effect|dep|genes Effect|nmod|END_ENTITY	-LSB- Effect of actovegin on intestinal mucosa and expression of bcl-2 / bax genes in rats with acute_radiation_enteritis -RSB- .
21324399	0	bax	90,93	bcl-2	84,89	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Attenuation of reperfusion-induced hepatocyte apoptosis is associated with reversed bcl-2 / bax ratio in hemi-hepatic artery-preserved portal occlusion .
22553633	0	bax	47,50	bcl-2	40,45	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|minocycline minocycline|nmod|expression expression|nmod|END_ENTITY	Effects of minocycline on expression of bcl-2 , bax in early retinal_neuropathy of diabetes in rats .
26030464	0	bax	38,41	bcl-2	32,37	bax	bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Regulation of apoptosis through bcl-2 / bax proteins expression and DNA damage by Zanthoxylum alatum .
26719039	0	bax	28,31	bcl-2	21,26	bax	bcl-2	581	596	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	Relationship between bcl-2 , bax , beclin-1 , and cathepsin-D proteins during postovulatory follicular regression in fish ovary .
26827541	0	bax	52,55	bcl-2	61,66	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	mRNA|nsubj|START_ENTITY mRNA|dobj|expression expression|amod|END_ENTITY	-LSB- Effects of Citalopram on frontal cortical neurons ' bax mRNA bcl-2 mRNA expression and cell apoptosis of rat after stress -RSB- .
7563251	0	bax	34,37	bcl-2	27,32	bax	bcl-2	12028(Tax:10090)	12043(Tax:10090)	Gene	Gene	junB|dep|START_ENTITY junB|compound|END_ENTITY	Differential regulation of bcl-2 , bax , c-fos , junB , and krox-24 expression in the cerebellum of Purkinje_cell_degeneration mutant mice .
7828536	0	bax	181,184	bcl-2	29,34	bax	bcl-2	100054674(Tax:9796)	24224(Tax:10116)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Expression Expression|nmod|members members|nmod|family family|amod|END_ENTITY	Expression of members of the bcl-2 gene family in the immature rat ovary : equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels .
8649796	0	bax	112,115	bcl-2	106,111	bax	bcl-2	581	596	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Drug-induced apoptosis in B-cell_chronic_lymphocytic_leukemia : relationship between p53 gene mutation and bcl-2 / bax proteins in drug resistance .
9253363	0	bax	189,192	bcl-2	42,47	bax	bcl-2	581	596	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|nmod|members members|nmod|family family|amod|END_ENTITY	Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium : glandular epithelial cell apoptosis is associated with increased expression of bax .
9501056	0	bax	25,28	bcl-2	19,24	bax	bcl-2	280730(Tax:9913)	281020(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Increased ratio of bcl-2 / bax expression is associated with bovine_leukemia virus-induced leukemogenesis in cattle .
9522213	0	bax	51,54	bcl-2	34,39	bax	bcl-2	581	596	Gene	Gene	related|parataxis|START_ENTITY related|advcl|END_ENTITY	Apoptosis is inversely related to bcl-2 but not to bax expression in salivary_gland_tumours .
9635706	0	bax	26,29	bcl-2	31,36	bax	bcl-2	581	596	Gene	Gene	START_ENTITY|dobj|status status|amod|END_ENTITY	Apoptosis , proliferation , bax , bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal_cancer .
9649682	0	bax	34,37	bcl-2	18,23	bax	bcl-2	581	596	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|homologue homologue|amod|END_ENTITY	Expression of the bcl-2 homologue bax in normal human skin , psoriasis_vulgaris and non-melanoma skin_cancers .
9656122	0	bax	39,42	bcl-2	32,37	bax	bcl-2	581	596	Gene	Gene	mcl-1|amod|START_ENTITY mcl-1|amod|END_ENTITY	Immunohistochemical analysis of bcl-2 , bax , mcl-1 , and bcl-X expression in ovarian surface epithelial_tumors .
9664974	0	bax	18,21	bcl-2	12,17	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Role of the bcl-2 / bax pathway in hepatocyte apoptosis during acute rejection after rat liver transplantation .
9664998	0	bax	128,131	bcl-2	14,19	bax	bcl-2	24887(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY upregulation|nmod|expression associated|nmod|upregulation mRNAs|parataxis|associated mRNAs|nsubj|Expression Expression|nmod|homologue homologue|amod|END_ENTITY	Expression of bcl-2 homologue mRNAs in rat liver allograft : rejection-induced cell apoptosis is associated with upregulation of bax and bcl-xs expression .
9817315	0	bax	6,9	bcl-2	0,5	bax	bcl-2	581	596	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	bcl-2 / bax expression and p53 gene status in human bladder_cancer : relationship to early recurrence with intravesical chemotherapy after resection .
9836559	0	bax	6,9	bcl-2	0,5	bax	bcl-2	581	596	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	bcl-2 / bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with prostate_cancer .
9949631	0	bax	16,19	bcl-2	10,15	bax	bcl-2	581	596	Gene	Gene	ratio|compound|START_ENTITY associated|nsubjpass|ratio END_ENTITY|parataxis|associated	Increased bcl-2 / bax ratio in B-cell_chronic_lymphocytic_leukemia is associated with a progressive pattern of disease .
10816347	0	bax	35,38	bcl-w	39,44	bax	bcl-w	581	599	Gene	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	Epidermal_growth_factor alters the bax : bcl-w ratio following massive small bowel resection .
11150501	0	bax	38,41	bcl-xL	53,59	bax	bcl-xL	581	598	Gene	Gene	START_ENTITY|nmod|that that|nmod|END_ENTITY	The substitution of the C-terminus of bax by that of bcl-xL does not affect its subcellular localization but abrogates its pro-apoptotic properties .
15973073	0	bax	50,53	bcl-xL	42,48	bax	bcl-xL	581	598	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
26719039	0	bax	28,31	beclin-1	33,41	bax	beclin-1	581	8678	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	Relationship between bcl-2 , bax , beclin-1 , and cathepsin-D proteins during postovulatory follicular regression in fish ovary .
11029754	0	bax	23,26	cytochrome_C	118,130	bax	cytochrome C	581	54205	Gene	Gene	cleavage|nmod|START_ENTITY generates|nsubj|cleavage generates|dobj|fragment fragment|acl:relcl|promotes promotes|dobj|release release|amod|END_ENTITY	N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome_C release and apoptotic cell death .
10908576	0	bax	24,27	p38_MAP_kinase	0,14	bax	p38 MAP kinase	581	1432	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	p38_MAP_kinase mediates bax translocation in nitric_oxide-induced apoptosis in neurons .
10487853	0	bax	18,21	p53	81,84	bax	p53	581	7157	Gene	Gene	Overexpression|nmod|START_ENTITY associated|nsubj|Overexpression associated|nmod|mutations mutations|nmod|motif motif|nmod|END_ENTITY	Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53 .
10537367	0	bax	96,99	p53	136,139	bax	p53	581	7157	Gene	Gene	START_ENTITY|nmod|alteration alteration|nmod|levels levels|compound|END_ENTITY	Tamoxifen-induced apoptosis in breast_cancer cells relates to down-regulation of bcl-2 , but not bax and bcl-X -LRB- L -RRB- , without alteration of p53 protein levels .
10559267	0	bax	55,58	p53	115,118	bax	p53	581	7157	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter mechanism|nmod|regulation dictated|nsubjpass|mechanism dictated|nmod|element element|compound|END_ENTITY	One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element .
10559267	0	bax	55,58	p53	92,95	bax	p53	581	7157	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element .
15973073	0	bax	50,53	p53	55,58	bax	p53	581	7157	Gene	Gene	expression|appos|START_ENTITY expression|appos|proteins proteins|compound|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
17145718	0	bax	130,133	p53	45,48	bax	p53	12028(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY trans-activation|nmod|expression cooperating|nmod|trans-activation enhances|advcl|cooperating enhances|dobj|effects effects|nmod|END_ENTITY	Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression .
27005522	0	bax	82,85	p53	25,28	bax	p53	581	7157	Gene	Gene	gene|compound|START_ENTITY efficiency|nmod|gene regulates|dobj|efficiency regulates|nsubj|TFIIS.h TFIIS.h|appos|target target|nmod|END_ENTITY	TFIIS.h , a new target of p53 , regulates transcription efficiency of pro-apoptotic bax gene .
7834749	0	bax	72,75	p53	17,20	bax	p53	581	7157	Gene	Gene	gene|compound|START_ENTITY activator|nmod|gene activator|nsubj|END_ENTITY	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene .
7970735	0	bax	13,16	p53	75,78	bax	p53	581	7157	Gene	Gene	Induction|nmod|START_ENTITY correlates|nsubj|Induction correlates|nmod|status status|compound|END_ENTITY	Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis .
8183578	0	bax	33,36	p53	51,54	bax	p53	581	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Immediate early up-regulation of bax expression by p53 but not TGF_beta_1 : a paradigm for distinct apoptotic pathways .
9354771	0	bax	66,69	p53	10,13	bax	p53	581	7157	Gene	Gene	expression|compound|START_ENTITY up-regulation|nmod|expression induces|nmod|up-regulation induces|nsubj|END_ENTITY	Wild-type p53 induces apoptosis in Hep3B through up-regulation of bax expression .
9389352	11	bax	1656,1659	p53	1578,1581	p53	bax	7157	581	Gene	Gene	changes|nmod|START_ENTITY produce|dobj|changes produce|nsubj|Treatment Treatment|nmod|cells cells|acl|containing containing|dobj|gene gene|compound|END_ENTITY	Treatment of CLL cells containing a wild type p53 gene with CdA , F-ara-A , or CLB , did not produce any consistent changes in bax or bcl-2 .
9546439	0	bax	71,74	p53	24,27	bax	p53	581	7157	Gene	Gene	effects|nmod|START_ENTITY mutations|nmod|effects mutations|compound|END_ENTITY	Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast .
9766533	0	bax	14,17	p53	83,86	bax	p53	581	7157	Gene	Gene	Comparison|nmod|START_ENTITY dehydrogenase|nsubj|Comparison dehydrogenase|nmod|expression expression|compound|END_ENTITY	Comparison of bax , waf1 , and IMP dehydrogenase regulation in response to wild-type p53 expression under normal growth conditions .
9070488	0	bcl-1	50,55	cyclin_D1	56,65	bcl-1	cyclin D1	595	595	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Molecular and immunohistochemical analysis of the bcl-1 / cyclin_D1 gene in laryngeal_squamous_cell_carcinomas : correlation of protein expression with lymph node metastases and advanced clinical stage .
11238466	0	bcl-10	107,113	E10	27,30	bcl-10	E10	8915	1461015(Tax:12657)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue , bcl-10 .
10924254	0	bcl-2	19,24	BAD	97,100	bcl-2	BAD	596	572	Gene	Gene	expression|amod|START_ENTITY combination|nmod|expression facilitates|nsubj|combination facilitates|dobj|destruction destruction|nmod|protein protein|compound|END_ENTITY	The combination of bcl-2 expression and NGF-deprivation facilitates the selective destruction of BAD protein in living sympathetic neurons .
7665145	0	bcl-2	14,19	BHRF-1	88,94	bcl-2	BHRF-1	596	3783706(Tax:10376)	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|nmod|END_ENTITY	Expression of bcl-2 protein and transcription of the Epstein-Barr_virus bcl-2 homologue BHRF-1 in Hodgkin 's _ disease : implications for different pathogenic mechanisms .
10233985	0	bcl-2	50,55	Bax	109,112	bcl-2	Bax	596	581	Gene	Gene	oncogene|amod|START_ENTITY oncogene|acl:relcl|inhibits inhibits|nmod|END_ENTITY	Epstein-Barr_virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak .
12481899	0	bcl-2	150,155	Bax	44,47	bcl-2	Bax	596	581	Gene	Gene	manner|amod|START_ENTITY apoptosis|nmod|manner reduce|nmod|apoptosis END_ENTITY|ccomp|reduce	Antisense oligonucleotides complementary to Bax transcripts reduce the susceptibility of B-cell_chronic_lymphocytic_leukaemia cells to apoptosis in a bcl-2 independent manner .
12539576	0	bcl-2	42,47	Bax	49,52	bcl-2	Bax	100009447(Tax:9986)	100355675(Tax:9986)	Gene	Gene	expression|amod|START_ENTITY expression|acl|END_ENTITY	Study on apoptosis and expression of P53 , bcl-2 , Bax in cardiac myocytys of congestive_heart_failure induced by ventricular pacing .
12882813	0	bcl-2	13,18	Bax	35,38	bcl-2	Bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	members|amod|START_ENTITY members|appos|END_ENTITY	Proapoptotic bcl-2 family members , Bax and Bak , are essential for developmental photoreceptor apoptosis .
16805752	0	bcl-2	5,10	Bax	0,3	bcl-2	Bax	596	581	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Bax , bcl-2 and c-kit expression in non-small-cell lung_cancer and their effects on prognosis .
19360919	0	bcl-2	91,96	Bax	97,100	bcl-2	Bax	596	581	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2 / Bax pathway .
10467396	0	bcl-2	76,81	Bcl-xL	82,88	bcl-2	Bcl-xL	596	598	Gene	Gene	interacts|nmod|START_ENTITY Bcl-2|dep|interacts END_ENTITY|nsubj|Bcl-2	Bcl-2 / E1B 19 kDa-interacting protein 3-like protein -LRB- Bnip3L -RRB- interacts with bcl-2 / Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability .
8596025	0	bcl-2	27,32	CD28	51,55	bcl-2	CD28	596	940	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of bcl-2 and bcl-x by CD3 , CD28 , and the IL-2_receptor in cloned CD4 + helper T cells .
10924092	0	bcl-2	27,32	CD34	51,55	bcl-2	CD34	596	947	Gene	Gene	homologs|amod|START_ENTITY homologs|nmod|END_ENTITY	Differential expression of bcl-2 homologs in human CD34 -LRB- + -RRB- hematopoietic progenitor cells induced to differentiate into erythroid or granulocytic cells .
12763212	0	bcl-2	39,44	CD34	52,56	bcl-2	CD34	596	947	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
8826891	0	bcl-2	19,24	CD34	90,94	bcl-2	CD34	596	947	Gene	Gene	blasts|amod|START_ENTITY Down-regulation|nmod|blasts Down-regulation|nmod|expression expression|compound|END_ENTITY	Down-regulation of bcl-2 in AML blasts by all-trans_retinoic_acid and its relationship to CD34 antigen expression .
9447823	0	bcl-2	5,10	CD34	70,74	bcl-2	CD34	596	947	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|rate rate|compound|END_ENTITY	High bcl-2 expression in acute_myeloid_leukemia cells correlates with CD34 positivity and complete remission rate .
7507474	0	bcl-2	94,99	CD5	114,117	bcl-2	CD5	12043(Tax:10090)	12507(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	H-2z homozygous New Zealand mice as a model for B-cell_chronic_lymphocytic_leukemia : elevated bcl-2 expression in CD5 B cells at premalignant and malignant stages .
8616092	0	bcl-2	95,100	CD5	10,13	bcl-2	CD5	596	921	Gene	Gene	expression|amod|START_ENTITY death|nmod|expression co-incidence|nmod|death apoptosis|dobj|co-incidence apoptosis|nsubj|B-cell B-cell|compound|END_ENTITY	Leukaemic CD5 + B-cell apoptosis : co-incidence of cell death and DNA fragmentation with reduced bcl-2 expression .
9407720	0	bcl-2	42,47	CD5	63,66	bcl-2	CD5	596	921	Gene	Gene	oncoprotein|amod|START_ENTITY evaluation|nmod|oncoprotein flow|dobj|evaluation flow|nmod|+ +|compound|END_ENTITY	Comparative flow cytometric evaluation of bcl-2 oncoprotein in CD5 + and CD5 - B-cell lymphoid_chronic_leukemias .
8228820	0	bcl-2	142,147	CD8	85,88	bcl-2	CD8	596	925	Gene	Gene	role|nmod|START_ENTITY thymocytes|dep|role thymocytes|acl|become become|nmod|onset onset|nmod|END_ENTITY	Immature thymocytes become sensitive to calcium-mediated apoptosis with the onset of CD8 , CD4 , and the T cell receptor expression : a role for bcl-2 ?
9375033	0	bcl-2	24,29	CD8	39,42	bcl-2	CD8	596	925	Gene	Gene	p26|amod|START_ENTITY p26|nmod|END_ENTITY	Decreased expression of bcl-2 -LRB- p26 -RRB- in CD8 -LRB- + -RRB- lymphocytes of patients with T-cell lymphoproliferative_disorders of large granular lymphocytes .
11076296	0	bcl-2	71,76	CD95	78,82	bcl-2	CD95	596	355	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Cytomorphological differentiation diagnosis and evaluation of p53mut , bcl-2 , CD95 in peripheral B-cell small cell lymphomas -RSB- .
8798441	0	bcl-2	66,71	CREB	0,4	bcl-2	CREB	596	1385	Gene	Gene	allele|amod|START_ENTITY regulators|nmod|allele lymphomas|nsubj|regulators function|advcl|lymphomas function|nsubj|proteins proteins|compound|END_ENTITY	CREB proteins function as positive regulators of the translocated bcl-2 allele in t -LRB- 14 ; 18 -RRB- _ lymphomas .
8816467	0	bcl-2	13,18	CREB	48,52	bcl-2	CREB	596	1385	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression phosphorylated|nsubj|Induction phosphorylated|dobj|proteins proteins|compound|END_ENTITY	Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and rescue from apoptosis .
9694712	0	bcl-2	127,132	Cytochrome_c	0,12	bcl-2	Cytochrome c	596	54205	Gene	Gene	mediated|nmod|START_ENTITY suppression|acl|mediated apoptosis|dobj|suppression induces|ccomp|apoptosis induces|nsubj|END_ENTITY	Cytochrome_c induces caspase-dependent apoptosis in intact hematopoietic cells and overrides apoptosis suppression mediated by bcl-2 , growth factor signaling , MAP-kinase-kinase , and malignant change .
15763593	0	bcl-2	25,30	Estrogen_receptor-alpha	0,23	bcl-2	Estrogen receptor-alpha	596	2099	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Estrogen_receptor-alpha , bcl-2 and c-myc gene expression in fibroadenomas and adjacent normal breast : association with nodule size , hormonal and reproductive features .
9376651	0	bcl-2	14,19	Fas_antigen	39,50	bcl-2	Fas antigen	596	355	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	Expression of bcl-2 protein and APO-1 -LRB- Fas_antigen -RRB- in the lung tissue from patients with idiopathic_pulmonary_fibrosis .
12168058	0	bcl-2	45,50	Fas_ligand	33,43	bcl-2	Fas ligand	596	356	Gene	Gene	Fas|dep|START_ENTITY Fas|dep|END_ENTITY	Apoptosis-related proteins -LRB- Fas , Fas_ligand , bcl-2 and p53 -RRB- in different types of human breast_tumors .
19852948	0	bcl-2	128,133	G_protein-coupled_receptor_kinase_5	0,35	bcl-2	G protein-coupled receptor kinase 5	12043(Tax:10090)	14773(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	G_protein-coupled_receptor_kinase_5 , overexpressed in the alpha-synuclein up-regulation model of Parkinson 's _ disease , regulates bcl-2 expression .
19520857	0	bcl-2	60,65	HuR	115,118	bcl-2	HuR	596	1994	Gene	Gene	turnover|amod|START_ENTITY turnover|acl|overcoming overcoming|dobj|activity activity|compound|END_ENTITY	B_cell_lymphoma _ -LRB- Bcl -RRB- -2 protein is the major determinant in bcl-2 adenine-uridine-rich element turnover overcoming HuR activity .
9010276	0	bcl-2	92,97	IFN-gamma	31,40	bcl-2	IFN-gamma	596	3458	Gene	Gene	expression|amod|START_ENTITY up-regulation|nmod|expression inhibits|nmod|up-regulation inhibits|nsubj|IL-5 IL-5|appos|END_ENTITY	IL-5 but not interferon-gamma -LRB- IFN-gamma -RRB- inhibits eosinophil apoptosis by up-regulation of bcl-2 expression .
9490649	0	bcl-2	26,31	IFN-gamma	83,92	bcl-2	IFN-gamma	596	3458	Gene	Gene	proteins|amod|START_ENTITY express|dobj|proteins express|nmod|END_ENTITY	Human eosinophils express bcl-2 family proteins : modulation of Mcl-1 expression by IFN-gamma .
9621132	0	bcl-2	33,38	IFN-gamma	93,102	bcl-2	IFN-gamma	596	3458	Gene	Gene	immunotherapy|amod|START_ENTITY immunotherapy|nmod|END_ENTITY	Alteration of cytokine genes and bcl-2 expression following immunotherapy with intralesional IFN-gamma in a patient with tumor-stage mycosis_fungoides .
9596995	0	bcl-2	91,96	IL-3	77,81	bcl-2	IL-3	596	3562	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	A phosphatidylcholine phospholipase C inhibitor , D609 , blocks interleukin-3 -LRB- IL-3 -RRB- - induced bcl-2 expression but not c-myc expression in human IL-3-dependent cells .
12366711	0	bcl-2	84,89	IL-6	144,148	bcl-2	IL-6	596	3569	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Incidence of apoptosis and cell proliferation in multiple_myeloma : correlation with bcl-2 protein expression and serum levels of interleukin-6 -LRB- IL-6 -RRB- and soluble IL-6 receptor .
15101720	0	bcl-2	53,58	IgH	59,62	bcl-2	IgH	596	3492	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|rearrangement rearrangement|compound|END_ENTITY	Correlation between histological subtype and type of bcl-2 / IgH rearrangement in follicular_lymphomas .
15875184	0	bcl-2	76,81	IgH	82,85	bcl-2	IgH	596	3492	Gene	Gene	translocation|amod|START_ENTITY translocation|compound|END_ENTITY	Molecular epidemiology of follicular_lymphoma in Chinese : relationship with bcl-2 / IgH translocation and bcl-6 397G/C polymorphism .
15990705	0	bcl-2	13,18	IgH	19,22	bcl-2	IgH	596	3492	Gene	Gene	Frequency|dep|START_ENTITY END_ENTITY|dep|Frequency	Frequency of bcl-2 / IgH translocation in patients with non-Hodgkin 's _ lymphoma and chronic_hepatitis_C_virus_infection .
16297448	0	bcl-2	4,9	IgH	10,13	bcl-2	IgH	596	3492	Gene	Gene	rearrangement|amod|START_ENTITY rearrangement|compound|END_ENTITY	The bcl-2 / IgH rearrangement in a population of 204 healthy individuals : occurrence , age and gender distribution , breakpoints , and detection method validity .
16530831	0	bcl-2	169,174	IgH	175,178	bcl-2	IgH	596	3492	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	One single dose of rituximab added to a standard regimen of CHOP in primary treatment of follicular_lymphoma appears to result in a high clearance rate from circulating bcl-2 / IgH positive cells : Is the end of molecular monitoring near ?
16532966	0	bcl-2	14,19	IgH	20,23	bcl-2	IgH	596	3492	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	-LSB- Detection of bcl-2 / IgH gene rearrangement in diffuse_large_B_cell_lymphoma by hemi-nested PCR -RSB- .
17157165	0	bcl-2	38,43	IgH	44,47	bcl-2	IgH	596	3492	Gene	Gene	rearrangements|amod|START_ENTITY rearrangements|compound|END_ENTITY	Cells carrying nonlymphoma-associated bcl-2 / IgH rearrangements -LRB- NLABR -RRB- are phenotypically related to follicular_lymphoma and can establish as long-term persisting clonal populations .
17408460	0	bcl-2	42,47	IgH	48,51	bcl-2	IgH	596	3492	Gene	Gene	spread|nmod|START_ENTITY follicular_lymphoma|dep|spread follicular_lymphoma|parataxis|+ +|nsubj|END_ENTITY	Stage I/II follicular_lymphoma : spread of bcl-2 / IgH + cells in blood and bone marrow from primary site of disease and possibility of clearance after involved field radiotherapy .
18695675	0	bcl-2	68,73	IgH	42,45	bcl-2	IgH	596	3492	Gene	Gene	region|amod|START_ENTITY enhancers|nmod|region cells|amod|enhancers cells|nmod:poss|END_ENTITY	Functional long-range interactions of the IgH 3 ' enhancers with the bcl-2 promoter region in t -LRB- 14 ; 18 -RRB- lymphoma cells .
19379568	0	bcl-2	14,19	IgH	20,23	bcl-2	IgH	596	3492	Gene	Gene	Detection|nmod|START_ENTITY Detection|dep|gene gene|compound|END_ENTITY	-LSB- Detection of bcl-2 / IgH fusion gene in lymphoma by real-time polymerase chain reaction and its clinical significance -RSB- .
20426554	0	bcl-2	43,48	IgH	49,52	bcl-2	IgH	596	3492	Gene	Gene	non-Hodgkin|amod|START_ENTITY non-Hodgkin|compound|END_ENTITY	A rapid two-step method for elimination of bcl-2 / IgH positive non-Hodgkin 's _ lymphoma cells from human blood or marrow stem cells , employing immunomagnetic purging with streptavidin-coated_ferrofluids .
21103627	0	bcl-2	46,51	IgH	52,55	bcl-2	IgH	596	3492	Gene	Gene	translocation|amod|START_ENTITY translocation|compound|END_ENTITY	Prognostic and predictive significance of the bcl-2 / IgH translocation in malignant follicular_lymphomas .
8417783	0	bcl-2	46,51	IgH	52,55	bcl-2	IgH	596	3492	Gene	Gene	expression|nmod|START_ENTITY Analysis|nmod|expression Analysis|dep|END_ENTITY	Analysis of the expression of the hybrid gene bcl-2 / IgH in follicular_lymphomas .
8700536	0	bcl-2	2,7	IgH	8,11	bcl-2	IgH	596	3492	Gene	Gene	transcript|amod|START_ENTITY transcript|compound|END_ENTITY	A bcl-2 / IgH antisense transcript deregulates bcl-2 gene expression in human follicular_lymphoma t -LRB- 14 ; 18 -RRB- cell lines .
8700536	0	bcl-2	45,50	IgH	8,11	bcl-2	IgH	596	3492	Gene	Gene	expression|amod|START_ENTITY lines|nsubj|expression deregulates|xcomp|lines deregulates|nsubj|transcript transcript|compound|END_ENTITY	A bcl-2 / IgH antisense transcript deregulates bcl-2 gene expression in human follicular_lymphoma t -LRB- 14 ; 18 -RRB- cell lines .
9592988	0	bcl-2	52,57	IgH	58,61	bcl-2	IgH	596	3492	Gene	Gene	B_lymphocytosis|nmod|START_ENTITY B_lymphocytosis|dep|rearrangements rearrangements|compound|END_ENTITY	Persistent polyclonal B_lymphocytosis with multiple bcl-2 / IgH rearrangements : a benign disorder .
8282815	0	bcl-2	89,94	Interleukin-10	0,14	bcl-2	Interleukin-10	596	3586	Gene	Gene	protein|amod|START_ENTITY induction|nmod|protein prevents|nmod|induction prevents|nsubj|END_ENTITY	Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein .
12763212	0	bcl-2	39,44	K-ras	27,32	bcl-2	K-ras	596	3845	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
21528323	0	bcl-2	24,29	K-ras	12,17	bcl-2	K-ras	596	3845	Gene	Gene	expression|amod|START_ENTITY Analysis|appos|expression Analysis|nmod|END_ENTITY	Analysis of K-ras , p53 , bcl-2 and Rb expression in non-small_cell_lung_cancer cell lines .
12444320	0	bcl-2	104,109	KIT	66,69	bcl-2	KIT	596	3815	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|Activation Activation|appos|END_ENTITY	Activation of human mast cells through stem_cell_factor receptor -LRB- KIT -RRB- is associated with expression of bcl-2 .
10216101	0	bcl-2	99,104	NF-kappaB	8,17	bcl-2	NF-kappaB	596	4790	Gene	Gene	apoptosis|nmod|START_ENTITY Role|nmod|apoptosis Role|nmod|END_ENTITY	Role of NF-kappaB in the rescue of multiple_myeloma cells from glucocorticoid-induced apoptosis by bcl-2 .
10738245	0	bcl-2	0,5	NF-kappaB	31,40	bcl-2	NF-kappaB	596	4790	Gene	Gene	over-expression|amod|START_ENTITY enhances|nsubj|over-expression enhances|dobj|activity activity|amod|END_ENTITY	bcl-2 over-expression enhances NF-kappaB activity and induces mmp-9 transcription in human MCF7 -LRB- ADR -RRB- breast-cancer cells .
10807870	0	bcl-2	89,94	NF-kappaB	146,155	bcl-2	NF-kappaB	596	4790	Gene	Gene	suppression|amod|START_ENTITY suppression|nmod|evidence evidence|nmod|importance importance|nmod|END_ENTITY	Hypoxia-induced endothelial apoptosis through nuclear_factor-kappaB -LRB- NF-kappaB -RRB- - mediated bcl-2 suppression : in vivo evidence of the importance of NF-kappaB in endothelial cell regulation .
10807870	0	bcl-2	89,94	NF-kappaB	69,78	bcl-2	NF-kappaB	596	4790	Gene	Gene	suppression|amod|START_ENTITY apoptosis|dep|suppression apoptosis|nmod|nuclear_factor-kappaB nuclear_factor-kappaB|appos|END_ENTITY	Hypoxia-induced endothelial apoptosis through nuclear_factor-kappaB -LRB- NF-kappaB -RRB- - mediated bcl-2 suppression : in vivo evidence of the importance of NF-kappaB in endothelial cell regulation .
18486908	0	bcl-2	129,134	NF-kappaB	96,105	bcl-2	NF-kappaB	12043(Tax:10090)	18033(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|amod|END_ENTITY	Ursolic_acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells .
18987666	0	bcl-2	148,153	NF-kappaB_p50	121,134	bcl-2	NF-kappaB p50	12043(Tax:10090)	18033(Tax:10090)	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	C/EBPalpha or C/EBPalpha oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-kappaB_p50 bound to the bcl-2 and FLIP gene promoters .
11023998	0	bcl-2	30,35	NOS1	56,60	bcl-2	NOS1	596	4842	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Preconditioning regulation of bcl-2 and p66shc by human NOS1 enhances tolerance to oxidative stress .
14993973	0	bcl-2	66,71	P53	62,65	bcl-2	P53	596	7157	Gene	Gene	C-myc|amod|START_ENTITY END_ENTITY|dobj|C-myc	-LSB- Study of apoptosis and expression of apoptotic related genes P53 bcl-2 C-myc in oral_lichen_planus -RSB- .
15792122	0	bcl-2	5,10	P53	0,3	bcl-2	P53	596	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	P53 , bcl-2 and Ki-67 expression in adenoid_cystic_carcinoma_of_the_palate .
25610057	0	bcl-2	5,10	P53	0,3	bcl-2	P53	596	7157	Gene	Gene	ki-67|amod|START_ENTITY status|amod|ki-67 END_ENTITY|appos|status	P53 , bcl-2 , ki-67 li -LRB- labeling index -RRB- status in benign , proliferative , and malignant ovarian surface epithelial_neoplasms .
25821312	0	bcl-2	43,48	P53	38,41	bcl-2	P53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of bleomycin A5 on caspase-3 , P53 , bcl-2 expression and telomerase activity in vascular endothelial cells .
9609655	0	bcl-2	5,10	P53	0,3	bcl-2	P53	596	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	P53 , bcl-2 , and Bax expression in renal_cell_carcinoma .
10465333	0	bcl-2	50,55	PCNA	44,48	bcl-2	PCNA	596	5111	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemically stained markers -LRB- p53 , PCNA , bcl-2 -RRB- in dysplastic_lesions of the larynx .
12763212	0	bcl-2	39,44	PCNA	46,50	bcl-2	PCNA	596	5111	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
12644474	0	bcl-2	74,79	Par-4	0,5	bcl-2	Par-4	596	5074	Gene	Gene	promoter|amod|START_ENTITY site|nmod|promoter regulates|nmod|site regulates|nsubj|END_ENTITY	Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter .
8988053	0	bcl-2	6,11	Raf-1	0,5	bcl-2	Raf-1	596	5894	Gene	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dep|phosphorylation	Raf-1 / bcl-2 phosphorylation : a step from microtubule damage to cell death .
15462102	0	bcl-2	41,46	TGF-beta1	94,103	bcl-2	TGF-beta1	596	7040	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Expression of apoptosis-related proteins bcl-2 and bax along with transforming growth factor -LRB- TGF-beta1 -RRB- in the kidney of patients with glomerulonephritides .
16566921	0	bcl-2	14,19	Ubc9	34,38	bcl-2	Ubc9	12043(Tax:10090)	22196(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of bcl-2 expression by Ubc9 .
10845553	0	bcl-2	0,5	VEGF	62,66	bcl-2	VEGF	596	7422	Gene	Gene	proteins|amod|START_ENTITY involved|nsubjpass|proteins involved|nmod|regulation regulation|nmod|END_ENTITY	bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung_cancer .
21233846	0	bcl-2	29,34	VEGF	71,75	bcl-2	VEGF	596	7422	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic_tumor cells .
9334807	0	bcl-2	20,25	WAF1/CIP1	35,44	bcl-2	WAF1/CIP1	596	1026	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction between bcl-2 and p21 -LRB- WAF1/CIP1 -RRB- in breast_carcinomas with wild-type p53 .
16076491	0	bcl-2	56,61	annexin_V	79,88	bcl-2	annexin V	596	308	Gene	Gene	protected|nmod|START_ENTITY cells|acl|protected continue|nsubj|cells continue|nmod|END_ENTITY	Lymphoma cells protected from apoptosis by dysregulated bcl-2 continue to bind annexin_V in response to B-cell receptor engagement : a cautionary tale .
10674827	0	bcl-2	26,31	bad	51,54	bcl-2	bad	596	572	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Expression pattern of the bcl-2 homologous protein bad in normal skin , psoriasis_vulgaris_and_keratinocytic_tumors .
10492046	0	bcl-2	58,63	bax	64,67	bcl-2	bax	596	581	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Oral_squamous_cell_carcinoma is associated with decreased bcl-2 / bax expression ratio and increased apoptosis .
11078910	0	bcl-2	114,119	bax	120,123	bcl-2	bax	596	581	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Differential sensitivity of MCF-7 and LCC2 cells , to multiple growth inhibitory agents : possible relation to high bcl-2 / bax ratio ?
11592113	0	bcl-2	96,101	bax	103,106	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	caspase-3|compound|START_ENTITY caspase-3|dep|END_ENTITY	Domoic_acid-induced neuronal_damage in the rat hippocampus : changes in apoptosis related genes -LRB- bcl-2 , bax , caspase-3 -RRB- and microglial response .
11759059	0	bcl-2	0,5	bax	6,9	bcl-2	bax	596	581	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	bcl-2 / bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with rectal_cancer .
11860909	0	bcl-2	60,65	bax	67,70	bcl-2	bax	100733337	100730890	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	-LSB- Effects of excessive iodine on apoptosis and expression of bcl-2 , bax genes in the cells of brain and thyroid gland in guinea_pigs -RSB- .
12210599	0	bcl-2	17,22	bax	23,26	bcl-2	bax	596	581	Gene	Gene	Image|amod|START_ENTITY Image|dep|END_ENTITY	Image cytometric bcl-2 : bax and bcl-2 : bcl-x ratios in invasive breast_carcinoma : correlation with prognosis .
12230942	0	bcl-2	66,71	bax	61,64	bcl-2	bax	596	581	Gene	Gene	expression|amod|START_ENTITY Effects|appos|expression Effects|appos|END_ENTITY	Effects of dl-praeruptorin_A on interleukin-6 level and Fas , bax , bcl-2 protein expression in ischemia-reperfusion myocardium .
12373145	0	bcl-2	51,56	bax	58,61	bcl-2	bax	596	581	Gene	Gene	bcl-x|compound|START_ENTITY bcl-x|dep|END_ENTITY	Hepatocellular_carcinoma and markers of apoptosis -LRB- bcl-2 , bax , bcl-x -RRB- : prognostic significance .
12525523	0	bcl-2	10,15	bax	17,20	bcl-2	bax	596	581	Gene	Gene	Survivin|amod|START_ENTITY END_ENTITY|nsubj|Survivin	Survivin , bcl-2 , bax , and bcl-X gene expression in sentinel lymph nodes from melanoma patients .
12934349	0	bcl-2	50,55	bax	57,60	bcl-2	bax	100009447(Tax:9986)	100355675(Tax:9986)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	-LSB- Effect of ischemic preconditioning on myocardial bcl-2 , bax , p53 gene expression during ischemia/reperfusion period in rabbits -RSB- .
14741615	0	bcl-2	38,43	bax	45,48	bcl-2	bax	596	581	Gene	Gene	caspase-3|amod|START_ENTITY caspase-3|amod|END_ENTITY	Effect of cobalt and chromium ions on bcl-2 , bax , caspase-3 , and caspase-8 expression in human U937 macrophages .
15655830	0	bcl-2	91,96	bax	97,100	bcl-2	bax	596	581	Gene	Gene	/|amod|START_ENTITY expression|nmod|/ Correlation|nmod|expression END_ENTITY|nsubj|Correlation	Correlation between expression of gastrin , somatostatin and cell apoptosis regulation gene bcl-2 / bax in large intestine carcinoma .
15719136	0	bcl-2	16,21	bax	23,26	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- The changes of bcl-2 , bax expression and neuron apoptosis in the hippocampus after the blockade of cervical lymphatics of rats -RSB- .
15973073	0	bcl-2	35,40	bax	50,53	bcl-2	bax	596	581	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
16339882	0	bcl-2	40,45	bax	35,38	bcl-2	bax	596	581	Gene	Gene	permeability|dep|START_ENTITY transition|amod|permeability pores|nsubj|transition pores|nmod|apoptosis apoptosis|dep|roles roles|nmod|END_ENTITY	Bistability in apoptosis : roles of bax , bcl-2 , and mitochondrial permeability transition pores .
16759520	0	bcl-2	65,70	bax	71,74	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- Beneficial effects of carvedilol on cardiomyocyte apoptosis and bcl-2 / bax expression after acute_myocardial_infarction an experiment with rats -RSB- .
18683683	0	bcl-2	10,15	bax	16,19	bcl-2	bax	596	581	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- Roles of bcl-2 / bax expression and oligodendrocyte apoptosis in the pathogenesis of heroin-induced spongiform_leucoencephalopathy -RSB- .
18928588	0	bcl-2	86,91	bax	92,95	bcl-2	bax	596	581	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Relationship between apoptotic effect of Resveratrol on KG-1 cells and expression of bcl-2 / bax -RSB- .
20021825	0	bcl-2	60,65	bax	66,69	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|genes genes|compound|END_ENTITY	-LSB- Effect of actovegin on intestinal mucosa and expression of bcl-2 / bax genes in rats with acute_radiation_enteritis -RSB- .
21324399	0	bcl-2	84,89	bax	90,93	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Attenuation of reperfusion-induced hepatocyte apoptosis is associated with reversed bcl-2 / bax ratio in hemi-hepatic artery-preserved portal occlusion .
22553633	0	bcl-2	40,45	bax	47,50	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY minocycline|nmod|expression Effects|nmod|minocycline END_ENTITY|nsubj|Effects	Effects of minocycline on expression of bcl-2 , bax in early retinal_neuropathy of diabetes in rats .
26030464	0	bcl-2	32,37	bax	38,41	bcl-2	bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Regulation of apoptosis through bcl-2 / bax proteins expression and DNA damage by Zanthoxylum alatum .
26719039	0	bcl-2	21,26	bax	28,31	bcl-2	bax	596	581	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Relationship between bcl-2 , bax , beclin-1 , and cathepsin-D proteins during postovulatory follicular regression in fish ovary .
26827541	0	bcl-2	61,66	bax	52,55	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mRNA|dobj|expression mRNA|nsubj|END_ENTITY	-LSB- Effects of Citalopram on frontal cortical neurons ' bax mRNA bcl-2 mRNA expression and cell apoptosis of rat after stress -RSB- .
7563251	0	bcl-2	27,32	bax	34,37	bcl-2	bax	12043(Tax:10090)	12028(Tax:10090)	Gene	Gene	junB|compound|START_ENTITY junB|dep|END_ENTITY	Differential regulation of bcl-2 , bax , c-fos , junB , and krox-24 expression in the cerebellum of Purkinje_cell_degeneration mutant mice .
7828536	0	bcl-2	29,34	bax	181,184	bcl-2	bax	24224(Tax:10116)	100054674(Tax:9796)	Gene	Gene	family|amod|START_ENTITY members|nmod|family Expression|nmod|members associated|nsubjpass|Expression associated|nmod|END_ENTITY	Expression of members of the bcl-2 gene family in the immature rat ovary : equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels .
8649796	0	bcl-2	106,111	bax	112,115	bcl-2	bax	596	581	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Drug-induced apoptosis in B-cell_chronic_lymphocytic_leukemia : relationship between p53 gene mutation and bcl-2 / bax proteins in drug resistance .
9253363	0	bcl-2	42,47	bax	189,192	bcl-2	bax	596	581	Gene	Gene	family|amod|START_ENTITY members|nmod|family expression|nmod|members associated|nsubjpass|expression associated|nmod|expression expression|nmod|END_ENTITY	Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium : glandular epithelial cell apoptosis is associated with increased expression of bax .
9501056	0	bcl-2	19,24	bax	25,28	bcl-2	bax	281020(Tax:9913)	280730(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Increased ratio of bcl-2 / bax expression is associated with bovine_leukemia virus-induced leukemogenesis in cattle .
9522213	0	bcl-2	34,39	bax	51,54	bcl-2	bax	596	581	Gene	Gene	related|advcl|START_ENTITY related|parataxis|END_ENTITY	Apoptosis is inversely related to bcl-2 but not to bax expression in salivary_gland_tumours .
9635706	0	bcl-2	31,36	bax	26,29	bcl-2	bax	596	581	Gene	Gene	status|amod|START_ENTITY END_ENTITY|dobj|status	Apoptosis , proliferation , bax , bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal_cancer .
9649682	0	bcl-2	18,23	bax	34,37	bcl-2	bax	596	581	Gene	Gene	homologue|amod|START_ENTITY Expression|nmod|homologue END_ENTITY|nsubj|Expression	Expression of the bcl-2 homologue bax in normal human skin , psoriasis_vulgaris and non-melanoma skin_cancers .
9656122	0	bcl-2	32,37	bax	39,42	bcl-2	bax	596	581	Gene	Gene	mcl-1|amod|START_ENTITY mcl-1|amod|END_ENTITY	Immunohistochemical analysis of bcl-2 , bax , mcl-1 , and bcl-X expression in ovarian surface epithelial_tumors .
9664974	0	bcl-2	12,17	bax	18,21	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Role of the bcl-2 / bax pathway in hepatocyte apoptosis during acute rejection after rat liver transplantation .
9664998	0	bcl-2	14,19	bax	128,131	bcl-2	bax	24224(Tax:10116)	24887(Tax:10116)	Gene	Gene	homologue|amod|START_ENTITY Expression|nmod|homologue mRNAs|nsubj|Expression mRNAs|parataxis|associated associated|nmod|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	Expression of bcl-2 homologue mRNAs in rat liver allograft : rejection-induced cell apoptosis is associated with upregulation of bax and bcl-xs expression .
9817315	0	bcl-2	0,5	bax	6,9	bcl-2	bax	596	581	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	bcl-2 / bax expression and p53 gene status in human bladder_cancer : relationship to early recurrence with intravesical chemotherapy after resection .
9836559	0	bcl-2	0,5	bax	6,9	bcl-2	bax	596	581	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	bcl-2 / bax ratio as a predictive marker for therapeutic response to radiotherapy in patients with prostate_cancer .
9949631	0	bcl-2	10,15	bax	16,19	bcl-2	bax	596	581	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|ratio ratio|compound|END_ENTITY	Increased bcl-2 / bax ratio in B-cell_chronic_lymphocytic_leukemia is associated with a progressive pattern of disease .
12538159	0	bcl-2	35,40	bcl-3	24,29	bcl-2	bcl-3	596	602	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Stronger correlation of bcl-3 than bcl-2 , bcl-xL , costimulation , or antioxidants with adjuvant-induced T cell survival .
10831353	0	bcl-2	95,100	bcl-XL	79,85	bcl-2	bcl-XL	596	598	Gene	Gene	function|amod|START_ENTITY succeeds|dobj|function succeeds|nsubj|expression expression|nmod|genes genes|nmod|END_ENTITY	Differential expression of antiapoptotic genes in human endometrial_carcinoma : bcl-XL succeeds bcl-2 function in neoplastic cells .
12576461	0	bcl-2	32,37	bcl-XL	39,45	bcl-2	bcl-XL	596	598	Gene	Gene	epidermal_growth_factor_receptor|compound|START_ENTITY epidermal_growth_factor_receptor|dep|END_ENTITY	Combined targeted inhibition of bcl-2 , bcl-XL , epidermal_growth_factor_receptor , and protein kinase A type I causes potent antitumor , apoptotic , and antiangiogenic activity .
11350916	0	bcl-2	68,73	bcl-xL	74,80	bcl-2	bcl-xL	596	598	Gene	Gene	induction|nmod|START_ENTITY induction|parataxis|oligonucleotide oligonucleotide|nsubj|antisense antisense|amod|END_ENTITY	p53-Independent induction of apoptosis in human melanoma cells by a bcl-2 / bcl-xL bispecific antisense oligonucleotide .
12031489	0	bcl-2	58,63	bcl-xL	64,70	bcl-2	bcl-xL	596	598	Gene	Gene	antisense|amod|START_ENTITY antisense|amod|END_ENTITY	Analysis of ribosyl-modified , mixed backbone analogs of a bcl-2 / bcl-xL antisense oligonucleotide .
14627985	0	bcl-2	35,40	bcl-xL	41,47	bcl-2	bcl-xL	596	598	Gene	Gene	oligonucleotide|amod|START_ENTITY oligonucleotide|amod|END_ENTITY	Treatment of melanoma cells with a bcl-2 / bcl-xL antisense oligonucleotide induces antiangiogenic activity .
15973073	0	bcl-2	35,40	bcl-xL	42,48	bcl-2	bcl-xL	596	598	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
19950582	0	bcl-2	43,48	bcl-xl	49,55	bcl-2	bcl-xl	596	598	Gene	Gene	-LSB-|xcomp|START_ENTITY END_ENTITY|dep|-LSB-	-LSB- The effects of antisense oligonucleotides bcl-2 / bcl-xl and bcl-2 on proliferation and apoptosis of breast_cancer cells -RSB- .
26719039	0	bcl-2	21,26	beclin-1	33,41	bcl-2	beclin-1	596	8678	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Relationship between bcl-2 , bax , beclin-1 , and cathepsin-D proteins during postovulatory follicular regression in fish ovary .
24710477	0	bcl-2	29,34	beclin_1	35,43	bcl-2	beclin 1	596	8678	Gene	Gene	Regulation|nmod|START_ENTITY /|nsubj|Regulation /|dobj|interaction interaction|amod|END_ENTITY	Regulation of the autophagic bcl-2 / beclin_1 interaction .
8752150	0	bcl-2	9,14	bfl-1	0,5	bcl-2	bfl-1	596	597	Gene	Gene	homologue|amod|START_ENTITY END_ENTITY|appos|homologue	bfl-1 , a bcl-2 homologue , suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity .
7563251	0	bcl-2	27,32	c-fos	39,44	bcl-2	c-fos	12043(Tax:10090)	14281(Tax:10090)	Gene	Gene	junB|compound|START_ENTITY junB|dep|END_ENTITY	Differential regulation of bcl-2 , bax , c-fos , junB , and krox-24 expression in the cerebellum of Purkinje_cell_degeneration mutant mice .
10567899	0	bcl-2	108,113	c-myc	0,5	bcl-2	c-myc	596	4609	Gene	Gene	over-expression|amod|START_ENTITY link|nmod|over-expression evidence|nmod|link genes|dep|evidence genes|amod|END_ENTITY	c-myc , p53 and bcl-2 , apoptosis-related genes in infiltrating breast_carcinomas : evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients .
11778549	0	bcl-2	96,101	c-myc	36,41	bcl-2	c-myc	596	4609	Gene	Gene	-RSB-|amod|START_ENTITY expression|nmod|-RSB- antisense|nmod|expression antisense|xcomp|END_ENTITY	-LSB- The effects of RA538 and antisense c-myc on cervical cancer cell lines with high expression of bcl-2 gene -RSB- .
12536628	0	bcl-2	15,20	c-myc	22,27	bcl-2	c-myc	596	4609	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	-LSB- Expression of bcl-2 , c-myc genes and their relationship in patients with acute_leukemia -RSB- .
1406975	0	bcl-2	54,59	c-myc	32,37	bcl-2	c-myc	596	4609	Gene	Gene	inhibited|advcl|START_ENTITY inhibited|nsubj|death death|acl|induced induced|advcl|END_ENTITY	Apoptotic cell death induced by c-myc is inhibited by bcl-2 .
17145575	0	bcl-2	70,75	c-myc	76,81	bcl-2	c-myc	596	4609	Gene	Gene	ASODNs|amod|START_ENTITY ASODNs|amod|END_ENTITY	Enhancing radiosensitivity of Hela cells by combining transfection of bcl-2 c-myc ASODNs .
2284100	0	bcl-2	51,56	c-myc	25,30	bcl-2	c-myc	596	4609	Gene	Gene	line|amod|START_ENTITY activation|nmod|line activation|nmod|END_ENTITY	Concurrent activation of c-myc and inactivation of bcl-2 by chromosomal translocation in a lymphoblastic_lymphoma cell line .
8943742	0	bcl-2	14,19	c-myc	70,75	bcl-2	c-myc	596	4609	Gene	Gene	oncoprotein|amod|START_ENTITY Expression|nmod|oncoprotein Expression|dep|comparison comparison|nmod|END_ENTITY	Expression of bcl-2 oncoprotein in pituitary_tumours : comparison with c-myc .
9310122	0	bcl-2	20,25	c-myc	27,32	bcl-2	c-myc	596	4609	Gene	Gene	proliferation|amod|START_ENTITY proliferation|amod|END_ENTITY	Cell proliferation , bcl-2 , c-myc , p53 and apoptosis as indicators of different aggressiveness in small_lymphocytic_lymphoma -LRB- SLL -RRB- .
15631088	0	bcl-2	46,51	caspase-3	53,62	bcl-2	caspase-3	24224(Tax:10116)	25402(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Effects of Carthamus tinctorius injection on bcl-2 , caspase-3 expression related to neurons apoptosis after local cerebral_ischemia -RSB- .
16548358	0	bcl-2	119,124	caspase-3	78,87	bcl-2	caspase-3	24224(Tax:10116)	25402(Tax:10116)	Gene	Gene	associated|xcomp|START_ENTITY associated|nsubj|Effect Effect|nmod|TX0201 TX0201|nmod|expression expression|nmod|molecule molecule|amod|END_ENTITY	-LSB- Effect of TX0201 on expression of the apoptosis signal transduction molecule caspase-3 and apoptosis associated genes bcl-2 and bax mRNA in brain tissue of rat analogue model of Alzheimer 's _ disease -RSB- .
17951202	0	bcl-2	6,11	caspase-3	32,41	bcl-2	caspase-3	596	836	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Human bcl-2 expression , cleaved caspase-3 , and KSHV LANA-1 in Kaposi_sarcoma lesions .
18514416	0	bcl-2	72,77	caspase-3	120,129	bcl-2	caspase-3	12043(Tax:10090)	12367(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY application|nmod|transcription application|nmod|END_ENTITY	Chronic application of nonylphenol-induced apoptosis via suppression of bcl-2 transcription and up-regulation of active caspase-3 in mouse brain .
25821312	0	bcl-2	43,48	caspase-3	27,36	bcl-2	caspase-3	596	836	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of bleomycin A5 on caspase-3 , P53 , bcl-2 expression and telomerase activity in vascular endothelial cells .
9808574	0	bcl-2	117,122	caspase-3	87,96	bcl-2	caspase-3	596	836	Gene	Gene	modulation|amod|START_ENTITY evidence|nmod|modulation END_ENTITY|nmod|evidence	Flavopiridol induces apoptosis in chronic_lymphocytic_leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53 .
15686664	0	bcl-2	28,33	erythropoietin	10,24	bcl-2	erythropoietin	24224(Tax:10116)	24335(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of erythropoietin on bcl-2 gene expression in rat cardiac myocytes after traumatic_brain_injury .
20335137	0	bcl-2	47,52	erythropoietin	29,43	bcl-2	erythropoietin	596	2056	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	-LSB- Effect of recombinant human erythropoietin on bcl-2 protein expression in the retina in a rabbit model of acute high intraocular pressure -RSB- .
12479069	0	bcl-2	59,64	gastrin	20,27	bcl-2	gastrin	596	2520	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	-LSB- Effect of external gastrin on apoptosis and expression of bcl-2 gene in gastric_cancer cells -RSB- .
15655830	0	bcl-2	91,96	gastrin	34,41	bcl-2	gastrin	596	2520	Gene	Gene	/|amod|START_ENTITY /|compound|END_ENTITY	Correlation between expression of gastrin , somatostatin and cell apoptosis regulation gene bcl-2 / bax in large intestine carcinoma .
14555646	0	bcl-2	30,35	gli-1	93,98	bcl-2	gli-1	12043(Tax:10090)	14632(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY mediated|nsubj|regulation mediated|nmod|hedgehog hedgehog|acl|signaling signaling|advcl|END_ENTITY	Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1 .
11297268	0	bcl-2	72,77	interleukin_10	14,28	bcl-2	interleukin 10	596	3586	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of interleukin_10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin 's _ lymphoma to apoptosis .
26725384	0	bcl-2	116,121	kip1	130,134	bcl-2	kip1	596	1027	Gene	Gene	Proteins|amod|START_ENTITY Proteins|appos|END_ENTITY	Effects of Rapamycin and Rapamycin-loaded Poly -LRB- lactic-co-glycolic -RRB- Acid Nanoparticles on Apoptosis and Expression of bcl-2 and p27 -LRB- kip1 -RRB- Proteins of Human Umbilical Arterial Vascular Smooth Muscle Cell .
9220450	0	bcl-2	38,43	nerve_growth_factor	58,77	bcl-2	nerve growth factor	596	4803	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Autocrine regulation of apoptosis and bcl-2 expression by nerve_growth_factor in early differentiating cerebellar granule neurons involves low affinity neurotrophin receptor .
20571027	0	bcl-2	27,32	nucleolin	41,50	bcl-2	nucleolin	596	4691	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U - rich_element-binding_factor_1 -LRB- AUF1 -RRB- .
27033900	0	bcl-2	133,138	p27	123,126	bcl-2	p27	596	10671	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27 , p53 , bcl-2 in canine breast_cancer cells .
10231398	0	bcl-2	0,5	p53	115,118	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|phenotype phenotype|nmod|irrespective irrespective|nmod|immunostaining immunostaining|compound|END_ENTITY	bcl-2 protein expression is associated with a prognostically favourable phenotype in breast_cancer irrespective of p53 immunostaining .
10424692	0	bcl-2	29,34	p53	24,27	bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	mRNAs|nsubj|START_ENTITY mRNAs|nmod|localization localization|nmod|END_ENTITY	In situ localization of p53 , bcl-2 and bax mRNAs in rat ocular tissue .
10567899	0	bcl-2	108,113	p53	7,10	bcl-2	p53	596	7157	Gene	Gene	over-expression|amod|START_ENTITY link|nmod|over-expression evidence|nmod|link genes|dep|evidence genes|amod|END_ENTITY	c-myc , p53 and bcl-2 , apoptosis-related genes in infiltrating breast_carcinomas : evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients .
10675490	0	bcl-2	72,77	p53	22,25	bcl-2	p53	12043(Tax:10090)	22060(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene suppressor|dobj|gene suppressor|nsubj|Downregulation Downregulation|nmod|tumor tumor|compound|END_ENTITY	Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic_acid_receptor_alpha-deficient transgenic_mice .
10778725	0	bcl-2	52,57	p53	47,50	bcl-2	p53	596	7157	Gene	Gene	Mib-1|dep|START_ENTITY Mib-1|compound|END_ENTITY	Pediatric_medulloblastoma : prognostic value of p53 , bcl-2 , Mib-1 , and microvessel density .
10843472	0	bcl-2	59,64	p53	66,69	bcl-2	p53	596	7157	Gene	Gene	Fas_ligand|dep|START_ENTITY Fas_ligand|dep|END_ENTITY	Apoptosis and apoptosis-related_proteins -LRB- Fas , Fas_ligand , bcl-2 , p53 -RRB- in macrophages of human ovarian_epithelial_tumors .
10861120	0	bcl-2	38,43	p53	33,36	bcl-2	p53	596	7157	Gene	Gene	products|amod|START_ENTITY products|compound|END_ENTITY	-LSB- Radiation-induced apoptosis and p53 , bcl-2 gene expression products in QGY-7703 cell line in vitro -RSB- .
10914720	0	bcl-2	12,17	p53	0,3	bcl-2	p53	596	7157	Gene	Gene	immunostaining|amod|START_ENTITY END_ENTITY|nmod|immunostaining	p53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast_cancer patients .
10930045	0	bcl-2	24,29	p53	55,58	bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	suppression|amod|START_ENTITY involvement|nmod|suppression involvement|nmod|repression repression|compound|END_ENTITY	Possible involvement of bcl-2 suppression in wild-type p53 gene-dependent cell growth repression in rat_osteosarcoma cells .
10953132	0	bcl-2	33,38	p53	0,3	bcl-2	p53	596	7157	Gene	Gene	associated|nmod|START_ENTITY accumulation|acl|associated accumulation|compound|END_ENTITY	p53 accumulation associated with bcl-2 , the proliferation marker MIB-1 and survival in patients with prostate_cancer subjected to watchful waiting .
11077443	0	bcl-2	13,18	p53	0,3	bcl-2	p53	24224(Tax:10116)	301300(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway .
11091754	0	bcl-2	14,19	p53	82,85	bcl-2	p53	596	7157	Gene	Gene	Protein|amod|START_ENTITY Expression|nmod|Protein Expression|nmod|Protein Protein|compound|END_ENTITY	Expression of bcl-2 Protein in Breast_Carcinoma with Correlation to Expression of p53 Protein and Clinicopathological Factors .
11313951	0	bcl-2	23,28	p53	43,46	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Negative regulation of bcl-2 expression by p53 in hematopoietic cells .
11432618	0	bcl-2	25,30	p53	20,23	bcl-2	p53	596	7157	Gene	Gene	HER2|nummod|START_ENTITY HER2|nummod|END_ENTITY	Evaluation of HER2 , p53 , bcl-2 , topoisomerase II-alpha , heat_shock proteins 27 and 70 in primary breast_cancer and metastatic ipsilateral axillary lymph nodes .
11769670	0	bcl-2	39,44	p53	46,49	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- A novel antiapoptosis gene , survivin , bcl-2 , p53 expression in cervical_carcinomas -RSB- .
11819301	0	bcl-2	70,75	p53	56,59	bcl-2	p53	596	7157	Gene	Gene	proliferation|amod|START_ENTITY proliferation|appos|END_ENTITY	Apoptosis and its relationship with cell proliferation , p53 , Waf1p21 , bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China .
11820589	0	bcl-2	11,16	p53	0,3	bcl-2	p53	596	7157	Gene	Gene	staining|amod|START_ENTITY staining|compound|END_ENTITY	p53 , MDM2 , bcl-2 staining in follicular_neoplasms of the thyroid gland .
12088454	0	bcl-2	128,133	p53	117,120	bcl-2	p53	596	7157	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Epithelial_neoplasms of the appendix and colorectum : an analysis of cell proliferation , apoptosis , and expression of p53 , CD44 , bcl-2 .
12217802	0	bcl-2	46,51	p53	6,9	bcl-2	p53	596	7157	Gene	Gene	rearrangement|amod|START_ENTITY carrying|dobj|rearrangement lymphomas|xcomp|carrying lymphomas|nsubj|mutations mutations|compound|END_ENTITY	Bcl-6 p53 mutations in lymphomas carrying the bcl-2 / Jh rearrangement .
12479855	0	bcl-2	54,59	p53	10,13	bcl-2	p53	596	7157	Gene	Gene	resistance|amod|START_ENTITY overexpression|nmod|resistance leads|xcomp|overexpression leads|nsubj|transduction transduction|compound|END_ENTITY	Antisense p53 transduction leads to overexpression of bcl-2 and dexamethasone resistance in multiple_myeloma .
12763212	0	bcl-2	39,44	p53	34,37	bcl-2	p53	596	7157	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
12796649	0	bcl-2	17,22	p53	12,15	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY confined|nsubj|expression confined|nsubj|role role|nmod|END_ENTITY	The role of p53 , bcl-2 and E-cadherin expression in predicting biochemical relapse for organ confined prostate_cancer in Taiwan .
14663636	0	bcl-2	36,41	p53	26,29	bcl-2	p53	596	7157	Gene	Gene	bax|nummod|START_ENTITY bax|compound|END_ENTITY	Induction of apoptosis by p53 , bax , bcl-2 , and p21 expressed in colorectal_cancer .
15032288	0	bcl-2	74,79	p53	69,72	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The prognostic significance of the immunohistochemical expression of p53 , bcl-2 , c-erb_B-2 and cathepsin-D in ovarian_cancer patients receiving platinum with cyclophosphamide or paclitaxel chemotherapy .
15168338	1	bcl-2	72,77	p53	67,70	bcl-2	p53	596	7157	Gene	Gene	immunohistochemical|amod|START_ENTITY immunohistochemical|dep|END_ENTITY	A TUNEL , p53 , bcl-2 , bag-1 and Bax immunohistochemical study .
15201979	0	bcl-2	48,53	p53	43,46	bcl-2	p53	596	7157	Gene	Gene	HER-2|amod|START_ENTITY expression|amod|HER-2 expression|nmod|END_ENTITY	Relation between HPV-DNA and expression of p53 , bcl-2 , p21WAF-1 , MIB-1 , HER-2 / neu and DNA ploidy in early cervical carcinoma : correlation with clinical outcome .
15973073	0	bcl-2	35,40	p53	55,58	bcl-2	p53	596	7157	Gene	Gene	expression|nmod|START_ENTITY expression|appos|proteins proteins|compound|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
16477877	0	bcl-2	34,39	p53	112,115	bcl-2	p53	596	7157	Gene	Gene	patients|amod|START_ENTITY expression|nmod|patients expression|dep|correlation correlation|nmod|significance significance|compound|END_ENTITY	Immunohistochemical expression of bcl-2 in Dukes ' stage B and C colorectal_carcinoma patients : correlation with p53 and ki-67 in evaluating prognostic significance .
16611376	0	bcl-2	86,91	p53	50,53	bcl-2	p53	596	7157	Gene	Gene	Fas|amod|START_ENTITY related|nsubj|Fas related|nmod|apoptosis apoptosis|nmod|END_ENTITY	In vitro folate_deficiency induces apoptosis by a p53 , Fas -LRB- Apo-1 , CD95 -RRB- independent , bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes .
17641794	0	bcl-2	63,68	p53	45,48	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY correlation|nmod|expression correlation|nmod|immunostains immunostains|nmod|END_ENTITY	The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal_carcinomas .
18386458	0	bcl-2	20,25	p53	38,41	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|appos|overexpression overexpression|compound|END_ENTITY	Immunohistochemical bcl-2 expression , p53 overexpression , PR and ER status in endometrial_carcinoma and survival outcomes .
19582475	0	bcl-2	22,27	p53	43,46	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Gambogic_acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells .
20591580	0	bcl-2	31,36	p53	26,29	bcl-2	p53	596	7157	Gene	Gene	defects|amod|START_ENTITY END_ENTITY|appos|defects	Apoptosis-related factors p53 , bcl-2 and the defects of force transmission in dilated_cardiomyopathy .
20721457	0	bcl-2	56,61	p53	51,54	bcl-2	p53	596	7157	Gene	Gene	expressions|amod|START_ENTITY expressions|nmod|END_ENTITY	Analysis of the immunohistochemical expressions of p53 , bcl-2 and Ki-67 in colorectal_adenocarcinoma and their correlations with the prognostic factors .
21315022	0	bcl-2	43,48	p53	38,41	bcl-2	p53	596	7157	Gene	Gene	expressions|amod|START_ENTITY expressions|nmod|END_ENTITY	-LSB- Study on the specific expressions of p53 , bcl-2 and c-myc in non-small_cell_lung_cancer with neuroendocrine differentiation -RSB- .
21528323	0	bcl-2	24,29	p53	19,22	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY Analysis|appos|expression Analysis|appos|END_ENTITY	Analysis of K-ras , p53 , bcl-2 and Rb expression in non-small_cell_lung_cancer cell lines .
21695979	0	bcl-2	27,32	p53	22,25	bcl-2	p53	596	7157	Gene	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	-LSB- Expression of Ki-67 , p53 , bcl-2 , estrogen receptors alpha in patients with clear_cell_renal_carcinoma and epidermal_growth_factor_receptor mutation -RSB- .
22995373	0	bcl-2	75,80	p53	60,63	bcl-2	p53	596	7157	Gene	Gene	bax|dep|START_ENTITY bax|compound|END_ENTITY	Immunohistochemistry with apoptotic-antiapoptotic proteins -LRB- p53 , p21 , bax , bcl-2 -RRB- , c-kit , telomerase , and metallothionein as a diagnostic aid in benign , borderline , and malignant serous and mucinous ovarian_tumors .
23677569	0	bcl-2	31,36	p53	102,105	bcl-2	p53	596	7157	Gene	Gene	cells|amod|START_ENTITY suppression|nmod|cells compensated|nsubjpass|suppression compensated|nmod|sensitivity sensitivity|appos|activity activity|compound|END_ENTITY	Oligonucleotide suppression of bcl-2 in LNCaP cells is compensated by increased androgen sensitivity , p53 and oncogene activity , and suppressed caspase-3 .
24695377	0	bcl-2	57,62	p53	79,82	bcl-2	p53	596	7157	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Interleukin_7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung_cancer cells .
27033900	0	bcl-2	133,138	p53	128,131	bcl-2	p53	596	7157	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27 , p53 , bcl-2 in canine breast_cancer cells .
7867012	0	bcl-2	41,46	p53	29,32	bcl-2	p53	596	7157	Gene	Gene	express|xcomp|START_ENTITY express|nsubj|Human_gliomas Human_gliomas|nmod|END_ENTITY	Human_gliomas with wild-type p53 express bcl-2 .
8183579	0	bcl-2	39,44	p53	17,20	bcl-2	p53	12043(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo .
8883414	0	bcl-2	0,5	p53	35,38	bcl-2	p53	596	7157	Gene	Gene	overexpression|amod|START_ENTITY combined|nsubj|overexpression combined|nmod|correlates correlates|compound|END_ENTITY	bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate_cancer .
9158413	0	bcl-2	0,5	p53	9,12	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	bcl-2 vs p53 protein expression and apoptotic rate in human nonmelanoma_skin_cancers .
9158704	0	bcl-2	12,17	p53	134,137	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY Analysis|nmod|expression Analysis|dep|association association|nmod|expression expression|compound|END_ENTITY	Analysis of bcl-2 expression in normal , inflamed , dysplastic nasopharyngeal epithelia , and nasopharyngeal_carcinoma : association with p53 expression .
9253035	0	bcl-2	40,45	p53	87,90	bcl-2	p53	596	7157	Gene	Gene	Expression|nmod|START_ENTITY dependent|nsubj|Expression dependent|nmod|protein protein|compound|END_ENTITY	Expression of the antiapoptotic protein bcl-2 is not dependent on the tumor suppressor p53 protein in Indian breast_carcinoma .
9334807	0	bcl-2	20,25	p53	82,85	bcl-2	p53	596	7157	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|breast_carcinomas breast_carcinomas|nmod|END_ENTITY	Interaction between bcl-2 and p21 -LRB- WAF1/CIP1 -RRB- in breast_carcinomas with wild-type p53 .
9596268	0	bcl-2	32,37	p53	27,30	bcl-2	p53	596	7157	Gene	Gene	vimentin|dep|START_ENTITY vimentin|compound|END_ENTITY	Prognostic significance of p53 , bcl-2 , vimentin , and S100 protein-positive Langerhans cells in endometrial_carcinoma .
9643573	0	bcl-2	84,89	p53	0,3	bcl-2	p53	596	7157	Gene	Gene	rearrangement|amod|START_ENTITY mutation|nmod|rearrangement mutation|compound|END_ENTITY	p53 mutation in a case of blastic transformation of follicular_lymphoma with double bcl-2 rearrangement -LRB- MBR and VCR -RRB- .
9808574	0	bcl-2	117,122	p53	162,165	bcl-2	p53	596	7157	Gene	Gene	modulation|amod|START_ENTITY evidence|nmod|modulation caspase-3|nmod|evidence END_ENTITY|amod|caspase-3	Flavopiridol induces apoptosis in chronic_lymphocytic_leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53 .
9849490	0	bcl-2	0,5	p53	34,37	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY reciprocal|nsubj|expression reciprocal|nmod|expression expression|compound|END_ENTITY	bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal_cancer .
9891509	0	bcl-2	31,36	p53	57,60	bcl-2	p53	596	7157	Gene	Gene	expression|nmod|START_ENTITY Relevance|nmod|expression Relevance|nmod|END_ENTITY	Relevance of the expression of bcl-2 in combination with p53 as a prognostic factor in breast_cancer .
9929161	0	bcl-2	0,5	p53	80,83	bcl-2	p53	596	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|lack lack|nmod|correlation correlation|nmod|END_ENTITY	bcl-2 protein expression in endometrial_carcinoma : the lack of correlation with p53 .
11912153	0	bcl-2	68,73	par-4	19,24	bcl-2	par-4	596	5074	Gene	Gene	down-regulating|xcomp|START_ENTITY apoptosis|advcl|down-regulating sensitizes|xcomp|apoptosis sensitizes|nsubj|END_ENTITY	In lymphatic cells par-4 sensitizes to apoptosis by down-regulating bcl-2 and promoting disruption of mitochondrial membrane potential and caspase activation .
15293457	0	bcl-2	50,55	proliferating_cell_nuclear_antigen	15,49	bcl-2	proliferating cell nuclear antigen	596	5111	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen / bcl-2 in gray gingival tissue -RSB- .
15803370	0	bcl-2	10,15	thioredoxin	74,85	bcl-2	thioredoxin	596	7295	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Antisense bcl-2 transfection up-regulates anti-apoptotic and anti-oxidant thioredoxin in neuroblastoma cells .
14660675	0	bcl-2	0,5	urokinase_plasminogen_activator_receptor	19,59	bcl-2	urokinase plasminogen activator receptor	596	5329	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	bcl-2 induction of urokinase_plasminogen_activator_receptor expression in human cancer cells through Sp1 activation : involvement of ERK1/ERK2 activity .
12538159	0	bcl-3	24,29	bcl-2	35,40	bcl-3	bcl-2	602	596	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	Stronger correlation of bcl-3 than bcl-2 , bcl-xL , costimulation , or antioxidants with adjuvant-induced T cell survival .
12800208	0	bcl-6	20,25	CD10	121,125	bcl-6	CD10	604	4311	Gene	Gene	immunoreactivity|compound|START_ENTITY value|nmod|immunoreactivity value|dep|identification identification|nmod|subset subset|nmod|large_B-cell_lymphomas large_B-cell_lymphomas|nummod|END_ENTITY	Prognostic value of bcl-6 , CD10 and CD38 immunoreactivity in stage I-II gastric_lymphomas : identification of a subset of CD10 + large_B-cell_lymphomas with a favorable outcome .
10831353	0	bcl-XL	79,85	bcl-2	95,100	bcl-XL	bcl-2	598	596	Gene	Gene	genes|nmod|START_ENTITY expression|nmod|genes succeeds|nsubj|expression succeeds|dobj|function function|amod|END_ENTITY	Differential expression of antiapoptotic genes in human endometrial_carcinoma : bcl-XL succeeds bcl-2 function in neoplastic cells .
12576461	0	bcl-XL	39,45	bcl-2	32,37	bcl-XL	bcl-2	598	596	Gene	Gene	epidermal_growth_factor_receptor|dep|START_ENTITY epidermal_growth_factor_receptor|compound|END_ENTITY	Combined targeted inhibition of bcl-2 , bcl-XL , epidermal_growth_factor_receptor , and protein kinase A type I causes potent antitumor , apoptotic , and antiangiogenic activity .
10816347	0	bcl-w	39,44	bax	35,38	bcl-w	bax	599	581	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|dep|ratio	Epidermal_growth_factor alters the bax : bcl-w ratio following massive small bowel resection .
12459462	0	bcl-x	50,55	NF-kappaB	33,42	bcl-x	NF-kappaB	12048(Tax:10090)	18033(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Bruton 's _ tyrosine_kinase targets NF-kappaB to the bcl-x promoter via a mechanism involving phospholipase_C-gamma2 following B_cell_antigen_receptor engagement .
23640331	0	bcl-x	30,35	Progesterone_receptor	0,21	bcl-x	Progesterone receptor	598	5241	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Progesterone_receptor induces bcl-x expression through intragenic binding sites favoring RNA polymerase II elongation .
12452453	0	bcl-xL	6,12	Bcl-2	0,5	bcl-xL	Bcl-2	598	596	Gene	Gene	treatment|amod|START_ENTITY sensitizes|nsubj|treatment END_ENTITY|parataxis|sensitizes	Bcl-2 / bcl-xL bispecific antisense treatment sensitizes breast_carcinoma cells to doxorubicin , paclitaxel and cyclophosphamide .
12904174	0	bcl-xL	70,76	Bcl-2	24,29	bcl-xL	Bcl-2	598	596	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulation|dep|expression regulation|nmod|members members|compound|END_ENTITY	Prolactin regulation of Bcl-2 family members : increased expression of bcl-xL but not mcl-1 or bad in Nb2-T cells .
11150501	0	bcl-xL	53,59	bax	38,41	bcl-xL	bax	598	581	Gene	Gene	that|nmod|START_ENTITY END_ENTITY|nmod|that	The substitution of the C-terminus of bax by that of bcl-xL does not affect its subcellular localization but abrogates its pro-apoptotic properties .
15973073	0	bcl-xL	42,48	bax	50,53	bcl-xL	bax	598	581	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
11350916	0	bcl-xL	74,80	bcl-2	68,73	bcl-xL	bcl-2	598	596	Gene	Gene	antisense|amod|START_ENTITY oligonucleotide|nsubj|antisense induction|parataxis|oligonucleotide induction|nmod|END_ENTITY	p53-Independent induction of apoptosis in human melanoma cells by a bcl-2 / bcl-xL bispecific antisense oligonucleotide .
12031489	0	bcl-xL	64,70	bcl-2	58,63	bcl-xL	bcl-2	598	596	Gene	Gene	antisense|amod|START_ENTITY antisense|amod|END_ENTITY	Analysis of ribosyl-modified , mixed backbone analogs of a bcl-2 / bcl-xL antisense oligonucleotide .
14627985	0	bcl-xL	41,47	bcl-2	35,40	bcl-xL	bcl-2	598	596	Gene	Gene	oligonucleotide|amod|START_ENTITY oligonucleotide|amod|END_ENTITY	Treatment of melanoma cells with a bcl-2 / bcl-xL antisense oligonucleotide induces antiangiogenic activity .
15973073	0	bcl-xL	42,48	bcl-2	35,40	bcl-xL	bcl-2	598	596	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
15973073	0	bcl-xL	42,48	p53	55,58	bcl-xL	p53	598	7157	Gene	Gene	expression|appos|START_ENTITY expression|appos|proteins proteins|compound|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
19950582	0	bcl-xl	49,55	bcl-2	43,48	bcl-xl	bcl-2	598	596	Gene	Gene	START_ENTITY|dep|-LSB- -LSB-|xcomp|END_ENTITY	-LSB- The effects of antisense oligonucleotides bcl-2 / bcl-xl and bcl-2 on proliferation and apoptosis of breast_cancer cells -RSB- .
9446659	0	bcr-abl	43,50	CD8	60,63	bcr-abl	CD8	25	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Dendritic cells stimulate the expansion of bcr-abl specific CD8 + T cells with cytotoxic activity against leukemic cells from patients with chronic_myeloid_leukemia .
9815665	0	bcr-abl	18,25	JAK1	47,51	bcr-abl	JAK1	25	3716	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Potential role of bcr-abl in the activation of JAK1 kinase .
23611214	0	bcr-abl	65,72	P210	74,78	bcr-abl	P210	25	2125	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	-LSB- A multicenter comparison study on the quantitative detection of bcr-abl -LRB- P210 -RRB- transcript levels in China -RSB- .
9672847	0	bcr-abl	102,109	bcr-abl	18,25	bcr-abl	bcr-abl	25	25	Gene	Gene	protein|amod|START_ENTITY expressing|dobj|protein cells|acl|expressing fail|nmod|cells fail|nsubj|specific specific|nmod|peptides peptides|amod|END_ENTITY	CTLs specific for bcr-abl joining region segment peptides fail to lyse_leukemia cells expressing p210 bcr-abl protein .
9672847	0	bcr-abl	18,25	bcr-abl	102,109	bcr-abl	bcr-abl	25	25	Gene	Gene	peptides|amod|START_ENTITY specific|nmod|peptides fail|nsubj|specific fail|nmod|cells cells|acl|expressing expressing|dobj|protein protein|amod|END_ENTITY	CTLs specific for bcr-abl joining region segment peptides fail to lyse_leukemia cells expressing p210 bcr-abl protein .
15368327	0	bcr-abl	14,21	c-abl	29,34	bcr-abl	c-abl	25	25	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibition of bcr-abl and/or c-abl gene expression by small interfering , double-stranded RNAs : cross-talk with cell proliferation factors and other oncogenes .
10586207	0	bcr-abl	5,12	p190	0,4	bcr-abl	p190	25	8506	Gene	Gene	rearrangement|amod|START_ENTITY rearrangement|amod|END_ENTITY	p190 bcr-abl rearrangement : a secondary cytogenetic event in some chronic myeloid_disorders ?
1847983	0	bcr-abl	71,78	p190	66,70	bcr-abl	p190	25	8506	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Establishment of a lymphoblastoid cell line , SD-1 , expressing the p190 bcr-abl chimaeric protein .
9360779	0	bcr-abl	126,133	p190	121,125	bcr-abl	p190	25	8506	Gene	Gene	oncogene|amod|START_ENTITY oncogene|amod|END_ENTITY	Ribozyme-mediated inhibition of a Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia cell line expressing the p190 bcr-abl oncogene .
15698792	0	bcr-abl	53,60	p210	48,52	bcr-abl	p210	25	2125	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Synthesis , structure-activity relationship , and p210 -LRB- bcr-abl -RRB- protein tyrosine kinase activity of novel AG_957 analogs .
9639422	0	bcr-abl	37,44	p210	32,36	bcr-abl	p210	25	2125	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Arginine_butyrate downregulates p210 bcr-abl expression and induces apoptosis in chronic_myelogenous_leukemia cells .
9672847	0	bcr-abl	102,109	p210	97,101	bcr-abl	p210	25	2125	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	CTLs specific for bcr-abl joining region segment peptides fail to lyse_leukemia cells expressing p210 bcr-abl protein .
9672847	0	bcr-abl	18,25	p210	97,101	bcr-abl	p210	25	2125	Gene	Gene	peptides|amod|START_ENTITY specific|nmod|peptides fail|nsubj|specific fail|nmod|cells cells|acl|expressing expressing|dobj|protein protein|amod|END_ENTITY	CTLs specific for bcr-abl joining region segment peptides fail to lyse_leukemia cells expressing p210 bcr-abl protein .
2440107	0	bcr/abl	22,29	P210	17,21	bcr/abl	P210	25;613	14027(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The CML-specific P210 bcr/abl protein , unlike v-abl , does not transform NIH/3T3 fibroblasts .
24170570	0	bean	52,56	diamine_oxidase	21,36	bean	diamine oxidase	146227	26	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Sequence analysis of diamine_oxidase gene from fava bean and its expression related to y-aminobutyric_acid accumulation in seeds germinating under hypoxia-NaCl stress .
18608549	0	bean	15,19	paraoxonase_1	29,42	bean	paraoxonase 1	146227	5444	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of soy bean on serum paraoxonase_1 activity and lipoproteins in hyperlipidemic postmenopausal women .
23894198	0	beclin-1	27,35	CD4	65,68	beclin-1	CD4	8678	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|nummod|END_ENTITY	Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory_syncytial_virus_infection .
26719039	0	beclin-1	33,41	bax	28,31	beclin-1	bax	8678	581	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Relationship between bcl-2 , bax , beclin-1 , and cathepsin-D proteins during postovulatory follicular regression in fish ovary .
26719039	0	beclin-1	33,41	bcl-2	21,26	beclin-1	bcl-2	8678	596	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Relationship between bcl-2 , bax , beclin-1 , and cathepsin-D proteins during postovulatory follicular regression in fish ovary .
24554038	0	beclin_1	14,22	Bcl-2	88,93	beclin 1	Bcl-2	8678	596	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of beclin_1 in primary salivary adenoid_cystic_carcinoma and its relation to Bcl-2 and p53 and prognosis .
26683082	0	beclin_1	119,127	Bcl-2	113,118	beclin 1	Bcl-2	8678	596	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|a-synuclein a-synuclein|advcl|activating activating|dobj|JNK_1 JNK_1|dep|END_ENTITY	Fasudil , a Rho kinase inhibitor , promotes the autophagic degradation of A53T a-synuclein by activating the JNK_1 / Bcl-2 / beclin_1 pathway .
23380076	0	beclin_1	36,44	Tissue_transglutaminase	0,23	beclin 1	Tissue transglutaminase	8678	7052	Gene	Gene	START_ENTITY|nsubj|cross-links cross-links|amod|END_ENTITY	Tissue_transglutaminase cross-links beclin_1 and regulates autophagy in MPP ___ - treated human SH-SY5Y cells .
24710477	0	beclin_1	35,43	bcl-2	29,34	beclin 1	bcl-2	8678	596	Gene	Gene	interaction|amod|START_ENTITY /|dobj|interaction /|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the autophagic bcl-2 / beclin_1 interaction .
20634405	0	beclin_1	148,156	hVps34	157,163	beclin 1	hVps34	8678	5289	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	The epidermal_growth_factor_receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin_1 / hVps34 complex .
19074429	0	bet	77,80	APOBEC3C	31,39	bet	APOBEC3C	92737	27350	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet .
20619088	0	beta-1	38,44	TNF-alpha	20,29	beta-1	TNF-alpha	3779	7124	Gene	Gene	induced|xcomp|START_ENTITY END_ENTITY|acl|induced	-LSB- The role of PKC to TNF-alpha induced beta-1 , 4-galactosyltransferase-I expression in endothelial cells -RSB- .
9607631	0	beta-1	123,129	VEGF	75,79	beta-1	VEGF	3779	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of macrophage production of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by hypoxia and transforming growth factor beta-1 .
12723015	0	beta-1	122,128	alpha-1	109,116	beta-1	alpha-1	3779	146	Gene	Gene	blockade|amod|START_ENTITY END_ENTITY|nmod|blockade	Adjunctive sympathoplegic therapy to ACE inhibition in Blacks with congestive_heart_failure : a comparison of alpha-1 with beta-1 blockade on exercise tolerance and cardiac sympathovagal reflex activity .
10849431	0	beta-1	50,56	thrombospondin-1	75,91	beta-1	thrombospondin-1	15129(Tax:10090)	21825(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Activation of platelet-transforming growth factor beta-1 in the absence of thrombospondin-1 .
23522389	0	beta-1_integrin	21,36	Timp1	0,5	beta-1 integrin	Timp1	3688	7076	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Timp1 interacts with beta-1_integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation .
26297111	0	beta-1_integrin	30,45	Timp1	9,14	beta-1 integrin	Timp1	3688	7076	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Erratum : Timp1 interacts with beta-1_integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation .
11426895	0	beta-2	14,20	Beta-3	0,6	beta-2	Beta-3	10242	1934	Gene	Gene	agonists|amod|START_ENTITY END_ENTITY|nmod|agonists	Beta-3 versus beta-2 adrenergic agonists and preterm_labour : in vitro uterine relaxation effects .
10512685	0	beta-2	27,33	ITGB2	49,54	beta-2	ITGB2	10242	3689	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A missense mutation in the beta-2 integrin gene -LRB- ITGB2 -RRB- causes canine leukocyte_adhesion_deficiency .
7726472	0	beta-2	77,83	transferrin	84,95	beta-2	transferrin	10242	7018	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Perilymph fistula : diagnosis by detection of perilymph in the middle ear by beta-2 transferrin immunofixation -RSB- .
8127790	0	beta-2-microglobulin	11,31	B2MG	33,37	beta-2-microglobulin	B2MG	567	567	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	-LSB- Levels of beta-2-microglobulin -LRB- B2MG -RRB- in blood serum of patients during the early phase after kidney transplantation -RSB- .
26983758	0	beta-2-microglobulin	44,64	TGF-b	85,90	beta-2-microglobulin	TGF-b	567	7040	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Human_epithelial-type_ovarian_tumour marker beta-2-microglobulin is regulated by the TGF-b signaling pathway .
17130852	0	beta-2_adrenoceptor	17,36	ADRB2	38,43	beta-2 adrenoceptor	ADRB2	154	154	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a beta-2_adrenoceptor -LRB- ADRB2 -RRB- gene variant with a blunted in vivo lipolysis and fat oxidation .
11552664	0	beta-2_microglobulin	34,54	ICAM-1	102,108	beta-2 microglobulin	ICAM-1	567	3383	Gene	Gene	intercellular_adhesion_molecule_1|amod|START_ENTITY intercellular_adhesion_molecule_1|appos|END_ENTITY	Effect of cladribine treatment on beta-2_microglobulin and soluble intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in patients with multiple_sclerosis .
9200670	0	beta-3AR	21,29	Beta-3_adrenoceptor	0,19	beta-3AR	Beta-3 adrenoceptor	11556(Tax:10090)	11556(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Beta-3_adrenoceptor -LRB- beta-3AR -RRB- expression in leptin treated OB/OB mice .
19741005	0	beta-Arrestin-2	0,15	P2Y1_receptor	61,74	beta-Arrestin-2	P2Y1 receptor	409	5028	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	beta-Arrestin-2 interaction and internalization of the human P2Y1_receptor are dependent on C-terminal phosphorylation sites .
7982906	0	beta-COP	51,59	Nef	34,37	beta-COP	Nef	9276	156110(Tax:11676)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Physical interaction of the HIV-1 Nef protein with beta-COP , a component of non-clathrin-coated vesicles essential for membrane traffic .
17167724	0	beta-Catenin	48,60	E-Cadherin	62,72	beta-Catenin	E-Cadherin	1499	999	Gene	Gene	expression|nmod|START_ENTITY Transfection|nmod|expression Transfection|amod|END_ENTITY	Transfection of nm23-H1 increased expression of beta-Catenin , E-Cadherin and TIMP-1 and decreased the expression of MMP-2 , CD44v6_and_VEGF and inhibited the metastatic potential of human non-small_cell_lung_cancer cell line L9981 .
17292359	0	beta-Catenin	0,12	P-cadherin	23,33	beta-Catenin	P-cadherin	12387(Tax:10090)	12560(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells .
19941816	0	beta-Catenin	122,134	alpha-Catenin	67,80	beta-Catenin	alpha-Catenin	1499	1495	Gene	Gene	beta-Catenin|nmod|START_ENTITY promotes|nmod|beta-Catenin promotes|dobj|disassociation disassociation|nmod|END_ENTITY	EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin .
19941816	0	beta-Catenin	86,98	alpha-Catenin	67,80	beta-Catenin	alpha-Catenin	1499	1495	Gene	Gene	promotes|nmod|START_ENTITY promotes|dobj|disassociation disassociation|nmod|END_ENTITY	EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin .
17315172	0	beta-Catenin	0,12	cyclin_D1	89,98	beta-Catenin	cyclin D1	1499	595	Gene	Gene	accumulation|amod|START_ENTITY accumulation|dep|role role|nmod|overexpression overexpression|amod|END_ENTITY	beta-Catenin nuclear accumulation in head and neck mucoepidermoid_carcinoma : its role in cyclin_D1 overexpression and tumor progression .
17167724	0	beta-Catenin	48,60	nm23-H1	16,23	beta-Catenin	nm23-H1	1499	4830	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transfection of nm23-H1 increased expression of beta-Catenin , E-Cadherin and TIMP-1 and decreased the expression of MMP-2 , CD44v6_and_VEGF and inhibited the metastatic potential of human non-small_cell_lung_cancer cell line L9981 .
16091738	0	beta-Catenin	0,12	tenascin-C	41,51	beta-Catenin	tenascin-C	1499	3371	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	beta-Catenin regulates the expression of tenascin-C in human colorectal_tumors .
12810642	0	beta-Catenin	0,12	vascular_endothelial_growth_factor	23,57	beta-Catenin	vascular endothelial growth factor	1499	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	beta-Catenin regulates vascular_endothelial_growth_factor expression in colon_cancer .
10453520	0	beta-Endorphin	1,15	IL-2	25,29	beta-Endorphin	IL-2	5443	3558	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	-LSB- beta-Endorphin enhances IL-2 and IFN-gamma gene expression in human blood mononuclear cells -RSB- .
7007411	0	beta-Endorphin	0,14	insulin	43,50	beta-Endorphin	insulin	5443	3630	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|nmod|END_ENTITY	beta-Endorphin stimulates the secretion of insulin and glucagon in humans .
3156142	0	beta-Endorphin	0,14	renin	33,38	beta-Endorphin	renin	5443	5972	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	beta-Endorphin stimulates plasma renin and aldosterone release in normal human subjects .
224076	0	beta-LPH	110,118	beta-endorphin	133,147	beta-LPH	beta-endorphin	5443	5443	Gene	Gene	conversion|amod|START_ENTITY conversion|nmod|END_ENTITY	ACTH , beta-LPH and beta-endorphin in pituitary_adenomas of the patients with Cushing 's _ disease : activation of beta-LPH conversion to beta-endorphin .
590341	0	beta-MSH	50,58	beta-melanocyte_stimulating_hormone	13,48	beta-MSH	beta-melanocyte stimulating hormone	5443	5443	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	An effect of beta-melanocyte_stimulating_hormone -LRB- beta-MSH -RRB- on alpha-motoneurones of cat spinal cord .
15950934	0	beta-Microseminoprotein	0,23	CRISP-3	30,37	beta-Microseminoprotein	CRISP-3	4477	10321	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	beta-Microseminoprotein binds CRISP-3 in human seminal plasma .
2933260	0	beta-N-acetyl_hexosaminidase	6,34	carcinoembryonic_antigen	143,167	beta-N-acetyl hexosaminidase	carcinoembryonic antigen	284004	1084	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Serum beta-N-acetyl_hexosaminidase -LRB- beta-NAH -RRB- as a discriminant between malignant and benign extrahepatic_biliary_obstruction : comparison with carcinoembryonic_antigen -LRB- CEA -RRB- .
20198314	0	beta-N-acetylglucosaminidase	31,59	O-GlcNAcase	61,72	beta-N-acetylglucosaminidase	O-GlcNAcase	10724	10724	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Elevation of nucleocytoplasmic beta-N-acetylglucosaminidase -LRB- O-GlcNAcase -RRB- activity in thyroid_cancers .
15080564	0	beta-N-acetylhexosaminidase	24,51	NAG	53,56	beta-N-acetylhexosaminidase	NAG	10724	10724	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Age dependence of serum beta-N-acetylhexosaminidase -LRB- NAG -RRB- activity .
12169689	0	beta-R1	95,102	SCYB11	104,110	beta-R1	SCYB11	6373	6373	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Requirement of phosphoinositide_3-kinase and Akt for interferon-beta-mediated induction of the beta-R1 -LRB- SCYB11 -RRB- gene .
17121810	0	beta-Spectrin	0,13	Ankyrin	41,48	beta-Spectrin	Ankyrin	32746(Tax:7227)	43770(Tax:7227)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	beta-Spectrin functions independently of Ankyrin to regulate the establishment and maintenance of axon connections in the Drosophila embryonic CNS .
20708156	0	beta-TRCP	93,102	SCF	89,92	beta-TRCP	SCF	8945	4254	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	Phosphorylation by casein_kinase_I promotes the turnover of the Mdm2 oncoprotein via the SCF -LRB- beta-TRCP -RRB- ubiquitin ligase .
20140206	0	beta-TrCP	0,9	aryl_hydrocarbon_receptor	81,106	beta-TrCP	aryl hydrocarbon receptor	8945	196	Gene	Gene	growth|amod|START_ENTITY growth|nmod|END_ENTITY	beta-TrCP inhibition reduces_prostate_cancer cell growth via upregulation of the aryl_hydrocarbon_receptor .
10074433	0	beta-TrCP	18,27	beta-catenin	59,71	beta-TrCP	beta-catenin	8945	1499	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell .
17001349	0	beta-Trcp	25,34	BRAF	10,14	beta-Trcp	BRAF	8945	673	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells .
15111311	0	beta-actin	55,65	ACTB	72,76	beta-actin	ACTB	728378	60	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Activation of the GLI oncogene through fusion with the beta-actin gene -LRB- ACTB -RRB- in a group of distinctive pericytic neoplasms : pericytoma with t -LRB- 7 ; 12 -RRB- .
9566589	0	beta-actin	55,65	IP3R1	48,53	beta-actin	IP3R1	728378	3708	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Effects of ischemic tolerance on mRNA levels of IP3R1 , beta-actin , and neuron-specific enolase in hippocampal CA1 area of the gerbil brain .
15940367	0	beta-actin	45,55	PHEX	24,28	beta-actin	PHEX	728378	5251	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype .
17337909	0	beta-actin	30,40	Transglutaminase_1	0,18	beta-actin	Transglutaminase 1	11461(Tax:10090)	21816(Tax:10090)	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Transglutaminase_1 stabilizes beta-actin in endothelial cells correlating with a stabilization of intercellular junctions .
9707615	0	beta-adaptin	13,25	ATM	0,3	beta-adaptin	ATM	163	472	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	ATM binds to beta-adaptin in cytoplasmic vesicles .
10571539	0	beta-adrenergic_receptor_kinase-1	78,111	betaARK1	113,121	beta-adrenergic receptor kinase-1	betaARK1	110355(Tax:10090)	110355(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Overexpression of the cardiac beta -LRB- 2 -RRB- - adrenergic_receptor and expression of a beta-adrenergic_receptor_kinase-1 -LRB- betaARK1 -RRB- inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic_injury .
9453569	0	beta-amyloid_peptide	131,151	beta-amyloid_precursor_protein	67,97	beta-amyloid peptide	beta-amyloid precursor protein	351	351	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Heparin oligosaccharides that pass the blood-brain barrier inhibit beta-amyloid_precursor_protein secretion and heparin binding to beta-amyloid_peptide .
17293612	0	beta-amyloid_precursor_protein	103,133	ABCG1	28,33	beta-amyloid precursor protein	ABCG1	351	9619	Gene	Gene	distribution|nmod|START_ENTITY modulates|dobj|distribution modulates|nsubj|END_ENTITY	The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid_precursor_protein .
16948926	0	beta-amyloid_precursor_protein	25,55	APP	57,60	beta-amyloid precursor protein	APP	351	351	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	High levels of Alzheimer beta-amyloid_precursor_protein -LRB- APP -RRB- in children with severely autistic_behavior_and_aggression .
19251455	0	beta-amyloid_precursor_protein	16,46	APP	48,51	beta-amyloid precursor protein	APP	351	351	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Two patterns of beta-amyloid_precursor_protein -LRB- APP -RRB- immunoreactivity in cases of blunt head_injury .
1939150	0	beta-amyloid_precursor_protein	30,60	APP	62,65	beta-amyloid precursor protein	APP	351	351	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Conversion of the Alzheimer 's beta-amyloid_precursor_protein -LRB- APP -RRB- Kunitz domain into a potent human neutrophil elastase inhibitor .
7790414	0	beta-amyloid_precursor_protein	24,54	APP	56,59	beta-amyloid precursor protein	APP	54226(Tax:10116)	54226(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Glial expression of the beta-amyloid_precursor_protein -LRB- APP -RRB- in global ischemia .
7898775	0	beta-amyloid_precursor_protein	14,44	APP	46,49	beta-amyloid precursor protein	APP	351	351	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of beta-amyloid_precursor_protein -LRB- APP -RRB- in human dorsal root ganglia .
17348862	0	beta-amyloid_precursor_protein	28,58	Calnuc	0,6	beta-amyloid precursor protein	Calnuc	351	4924	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Calnuc binds to Alzheimer 's beta-amyloid_precursor_protein and affects its biogenesis .
11378243	0	beta-amyloid_precursor_protein	56,86	Calreticulin	0,12	beta-amyloid precursor protein	Calreticulin	351	811	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Calreticulin functions as a molecular chaperone for the beta-amyloid_precursor_protein .
12089154	0	beta-amyloid_precursor_protein	34,64	Fe65	0,4	beta-amyloid precursor protein	Fe65	54226(Tax:10116)	29722(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Fe65 , a ligand of the Alzheimer 's beta-amyloid_precursor_protein , blocks cell cycle progression by down-regulating thymidylate_synthase expression .
10081969	0	beta-amyloid_precursor_protein	75,105	Fe65L2	27,33	beta-amyloid precursor protein	Fe65L2	351	10307	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of human Fe65L2 and its interaction with the Alzheimer 's beta-amyloid_precursor_protein .
15944381	0	beta-amyloid_precursor_protein	32,62	JNK3	107,111	beta-amyloid precursor protein	JNK3	351	5602	Gene	Gene	regulation|nmod|START_ENTITY kinase|nsubj|regulation kinase|dobj|END_ENTITY	Physiological regulation of the beta-amyloid_precursor_protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation .
11359873	0	beta-amyloid_precursor_protein	62,92	Nerve_growth_factor	0,19	beta-amyloid precursor protein	Nerve growth factor	54226(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Nerve_growth_factor modulates the expression and secretion of beta-amyloid_precursor_protein through different mechanisms in PC12 cells .
8667031	0	beta-amyloid_precursor_protein	37,67	Nerve_growth_factor	0,19	beta-amyloid precursor protein	Nerve growth factor	54226(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Nerve_growth_factor and ras regulate beta-amyloid_precursor_protein gene expression in PC12 cells .
12435726	0	beta-amyloid_precursor_protein	78,108	Presenilin-1	0,12	beta-amyloid precursor protein	Presenilin-1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid_precursor_protein .
9453569	0	beta-amyloid_precursor_protein	67,97	beta-amyloid_peptide	131,151	beta-amyloid precursor protein	beta-amyloid peptide	351	351	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Heparin oligosaccharides that pass the blood-brain barrier inhibit beta-amyloid_precursor_protein secretion and heparin binding to beta-amyloid_peptide .
14756823	0	beta-amyloid_precursor_protein	14,44	brain-derived_neurotrophic_factor	59,92	beta-amyloid precursor protein	brain-derived neurotrophic factor	351	627	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of beta-amyloid_precursor_protein expression by brain-derived_neurotrophic_factor involves activation of both the Ras and phosphatidylinositide_3-kinase signalling pathways .
19276086	0	beta-amyloid_precursor_protein	58,88	presenilin_1	29,41	beta-amyloid precursor protein	presenilin 1	11820(Tax:10090)	19164(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|trafficking trafficking|nmod|END_ENTITY	Intracellular trafficking of presenilin_1 is regulated by beta-amyloid_precursor_protein and phospholipase_D1 .
15837568	0	beta-amyloid_precursor_protein	15,45	tumor_necrosis_factor-alpha	75,102	beta-amyloid precursor protein	tumor necrosis factor-alpha	351	7124	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Antibody-bound beta-amyloid_precursor_protein stimulates the production of tumor_necrosis_factor-alpha and monocyte_chemoattractant_protein-1 by cortical neurons .
16374707	0	beta-arrestin-2	65,80	G-protein_receptor_kinase_3	36,63	beta-arrestin-2	G-protein receptor kinase 3	409	157	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	The fine-structural distribution of G-protein_receptor_kinase_3 , beta-arrestin-2 , Ca2 + / calmodulin-dependent_protein_kinase_II and phosphodiesterase PDE1C2 , and a Cl -LRB- - -RRB- - cotransporter in rodent olfactory epithelia .
19890360	0	beta-arrestin-2	150,165	THP-1	169,174	beta-arrestin-2	THP-1	409	2736	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Fenoterol , a beta -LRB- 2 -RRB- - adrenoceptor agonist , inhibits LPS-induced membrane-bound CD14 , TLR4/CD14 complex , and inflammatory cytokines production through beta-arrestin-2 in THP-1 cell line .
19239323	0	beta-arrestin2	0,14	Akt	72,75	beta-arrestin2	Akt	409	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	beta-arrestin2 inhibits opioid-induced breast_cancer cell death through Akt and caspase-8 pathways .
19325136	0	beta-arrestin2	137,151	nuclear_factor_kappa_B	75,97	beta-arrestin2	nuclear factor kappa B	409	4790	Gene	Gene	signaling|advcl|START_ENTITY END_ENTITY|acl|signaling	The type III transforming growth factor-beta receptor negatively regulates nuclear_factor_kappa_B signaling through its interaction with beta-arrestin2 .
20664520	0	beta-arrestin_2	72,87	AC2	67,70	beta-arrestin 2	AC2	409	108	Gene	Gene	complex|amod|START_ENTITY complex|dep|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
20664520	0	beta-arrestin_2	72,87	AKAP79	59,65	beta-arrestin 2	AKAP79	409	9495	Gene	Gene	complex|amod|START_ENTITY complex|dep|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
20664520	0	beta-arrestin_2	72,87	RXFP1	52,57	beta-arrestin 2	RXFP1	409	59350	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Sub-picomolar relaxin signalling by a pre-assembled RXFP1 , AKAP79 , AC2 , beta-arrestin_2 , PDE4D3 complex .
15528268	0	beta-arrestin_2	53,68	glucagon-like_peptide-1	20,43	beta-arrestin 2	glucagon-like peptide-1	409	2641	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Characterization of glucagon-like_peptide-1 receptor beta-arrestin_2 interaction : a high-affinity receptor phenotype .
9367255	0	beta-calcitonin_gene-related_peptide	14,50	brain_derived_neurotrophic_factor	103,136	beta-calcitonin gene-related peptide	brain derived neurotrophic factor	24241(Tax:10116)	24225(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of beta-calcitonin_gene-related_peptide in axotomized rubrospinal neurons and the effect of brain_derived_neurotrophic_factor .
20122251	0	beta-carotene_oxygenase_2	27,52	BCO2	54,58	beta-carotene oxygenase 2	BCO2	100286796(Tax:9940)	100286796(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A nonsense mutation in the beta-carotene_oxygenase_2 -LRB- BCO2 -RRB- gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep -LRB- Ovis_aries -RRB- .
10980707	0	beta-catenin	47,59	APC	33,36	beta-catenin	APC	1499	324	Gene	Gene	localization|amod|START_ENTITY regulates|dobj|localization regulates|nsubj|shuttling shuttling|nmod|END_ENTITY	Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover .
11062151	0	beta-catenin	14,26	APC	43,46	beta-catenin	APC	1499	324	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues .
11396184	0	beta-catenin	52,64	APC	97,100	beta-catenin	APC	1499	324	Gene	Gene	expression|nmod|START_ENTITY related|nsubjpass|expression related|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal_cancer .
12628243	0	beta-catenin	39,51	APC	148,151	beta-catenin	APC	1499	324	Gene	Gene	interaction|nmod|START_ENTITY Differences|nmod|interaction Differences|nmod|protein protein|compound|END_ENTITY	Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino_acid residue repeats of the APC protein .
14654913	0	beta-catenin	24,36	APC	100,103	beta-catenin	APC	1499	324	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|nmod|region region|nmod|gene gene|compound|END_ENTITY	Nuclear accumulation of beta-catenin without an additional somatic mutation in coding region of the APC gene in hepatoblastoma from a familial_adenomatous_polyposis patient .
17968317	0	beta-catenin	21,33	APC	6,9	beta-catenin	APC	31151(Tax:7227)	44642(Tax:7227)	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model .
19966865	0	beta-catenin	62,74	APC	104,107	beta-catenin	APC	1499	324	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|mutations mutations|compound|END_ENTITY	Contribution of the 15 amino_acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal_tumours from FAP patients .
19966865	0	beta-catenin	62,74	APC	55,58	beta-catenin	APC	1499	324	Gene	Gene	degradation|amod|START_ENTITY amino_acid|nmod|degradation amino_acid|dobj|repeats repeats|nmod|END_ENTITY	Contribution of the 15 amino_acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal_tumours from FAP patients .
8259518	0	beta-catenin	41,53	APC	19,22	beta-catenin	APC	1499	324	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|product product|compound|END_ENTITY	Association of the APC gene product with beta-catenin .
8670282	0	beta-catenin	50,62	APC	29,32	beta-catenin	APC	12387(Tax:10090)	11789(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY colocalizes|nmod|cells END_ENTITY|dobj|colocalizes	The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells .
9199178	0	beta-catenin	12,24	APC	43,46	beta-catenin	APC	477032(Tax:9615)	479139(Tax:9615)	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|protein protein|compound|END_ENTITY	Dynamics of beta-catenin interactions with APC protein regulate epithelial tubulogenesis .
17145894	0	beta-catenin	57,69	Adiponectin	0,11	beta-catenin	Adiponectin	1499	9370	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Adiponectin modulates the glycogen_synthase_kinase-3beta / beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude_mice .
19850036	0	beta-catenin	20,32	Akt	65,68	beta-catenin	Akt	1499	207	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|nmod|END_ENTITY	Osteopontin induces beta-catenin signaling through activation of Akt in prostate_cancer cells .
10602475	0	beta-catenin	27,39	Apc	73,76	beta-catenin	Apc	12387(Tax:10090)	11789(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY marks|nsubj|expression marks|dobj|change change|nmod|mice mice|compound|END_ENTITY	Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice , but not all lesions arising in Msh2 deficient mice .
10992298	0	beta-catenin	73,85	Apc	8,11	beta-catenin	Apc	12387(Tax:10090)	11789(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY inactivate|dobj|activity capacity|acl|inactivate selected|nmod|capacity selected|nsubjpass|mutations mutations|compound|END_ENTITY	Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity .
15563600	0	beta-catenin	51,63	Apc	29,32	beta-catenin	Apc	12387(Tax:10090)	11789(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY activates|dobj|signaling activates|nsubj|disruption disruption|nmod|END_ENTITY	Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular_carcinomas .
19248780	0	beta-catenin	81,93	Apc	4,7	beta-catenin	Apc	12387(Tax:10090)	11789(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression polyposis|acl|associated develops|dobj|polyposis develops|nsubj|mouse mouse|compound|END_ENTITY	The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression .
10023673	0	beta-catenin	45,57	Axin	0,4	beta-catenin	Axin	1499	8312	Gene	Gene	accumulation|nmod|START_ENTITY prevents|dobj|accumulation prevents|nsubj|END_ENTITY	Axin prevents Wnt-3a-induced accumulation of beta-catenin .
10698523	0	beta-catenin	99,111	Axin	154,158	beta-catenin	Axin	1499	8312	Gene	Gene	phosphatase_2A|compound|START_ENTITY phosphatase_2A|acl|complexed complexed|nmod|END_ENTITY	GSK-3beta-dependent phosphorylation of adenomatous_polyposis_coli gene product can be modulated by beta-catenin and protein phosphatase_2A complexed with Axin .
10722668	0	beta-catenin	19,31	Axin	97,101	beta-catenin	Axin	1499	8312	Gene	Gene	APC|amod|START_ENTITY Down-regulation|nmod|APC requires|nsubj|Down-regulation requires|nmod|END_ENTITY	Down-regulation of beta-catenin by the colorectal_tumor suppressor APC requires association with Axin and beta-catenin .
14981260	0	beta-catenin	76,88	Axin	33,37	beta-catenin	Axin	31151(Tax:7227)	43565(Tax:7227)	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|shuttling shuttling|nmod|END_ENTITY	Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin .
15063782	0	beta-catenin	65,77	Axin	55,59	beta-catenin	Axin	1499	8312	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|interaction interaction|nmod|END_ENTITY	Cyclin-dependent_kinase_2 regulates the interaction of Axin with beta-catenin .
15067328	0	beta-catenin	56,68	Axin	70,74	beta-catenin	Axin	1499	8312	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	Immunohistochemical analysis and mutational analyses of beta-catenin , Axin family and APC genes in hepatocellular_carcinomas .
17374607	0	beta-catenin	83,95	Axin	0,4	beta-catenin	Axin	1499	8312	Gene	Gene	degradation|nmod|START_ENTITY inhibits|nmod|degradation inhibits|nsubj|END_ENTITY	Axin inhibits extracellular_signal-regulated_kinase pathway by Ras degradation via beta-catenin .
18217212	0	beta-catenin	94,106	Axin	128,132	beta-catenin	Axin	1499	8312	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	ATRA-inhibited proliferation in glioma cells is associated with subcellular redistribution of beta-catenin via up-regulation of Axin .
18509060	0	beta-catenin	113,125	Axin	56,60	beta-catenin	Axin	399274(Tax:8355)	398097(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY inhibiting|dobj|phosphorylation transduces|advcl|inhibiting transduces|dobj|signal signal|nmod|degradation degradation|compound|END_ENTITY	LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3 's phosphorylation of beta-catenin .
19565571	0	beta-catenin	17,29	Axin	57,61	beta-catenin	Axin	399274(Tax:8355)	398097(Tax:8355)	Gene	Gene	Threonine|nmod|START_ENTITY regulates|nsubj|Threonine regulates|nmod|END_ENTITY	Threonine 393 of beta-catenin regulates interaction with Axin .
20122174	0	beta-catenin	43,55	Axin	0,4	beta-catenin	Axin	1499	8312	Gene	Gene	transcription|nmod|START_ENTITY downregulates|dobj|transcription downregulates|nsubj|END_ENTITY	Axin downregulates TCF-4 transcription via beta-catenin , but not p53 , and inhibits the proliferation and invasion of lung_cancer cells .
20719112	0	beta-catenin	57,69	Axin	17,21	beta-catenin	Axin	1499	8312	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|compound|END_ENTITY	-LSB- Transfection of Axin Gene Down-regulates Expressions of beta-catenin and TCF-4 and Inhibits the Proliferation and Invasive Ability of Lung_Cancer Cells . -RSB- .
9734785	0	beta-catenin	65,77	Axin	0,4	beta-catenin	Axin	1499	8312	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Axin , an inhibitor of the Wnt signalling pathway , interacts with beta-catenin , GSK-3beta and APC and reduces the beta-catenin level .
11560894	0	beta-catenin	37,49	BAR-1	59,64	beta-catenin	BAR-1	31151(Tax:7227)	180982(Tax:6239)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	The divergent Caenorhabditis_elegans beta-catenin proteins BAR-1 , WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo .
19795382	0	beta-catenin	16,28	BMP-2	0,5	beta-catenin	BMP-2	12387(Tax:10090)	12156(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts .
17318191	0	beta-catenin	19,31	Bcr-Abl	0,7	beta-catenin	Bcr-Abl	1499	25	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Bcr-Abl stabilizes beta-catenin in chronic_myeloid_leukemia through its tyrosine phosphorylation .
10769018	0	beta-catenin	51,63	CBP	32,35	beta-catenin	CBP	399274(Tax:8355)	373795(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression .
11973335	0	beta-catenin	15,27	CBP	53,56	beta-catenin	CBP	1499	1387	Gene	Gene	Acetylation|nmod|START_ENTITY Acetylation|nmod|CREB-binding_protein CREB-binding_protein|appos|END_ENTITY	Acetylation of beta-catenin by CREB-binding_protein -LRB- CBP -RRB- .
12000790	0	beta-catenin	37,49	CKI	14,17	beta-catenin	CKI	1499	1119	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45 : a molecular switch for the Wnt pathway .
11973335	0	beta-catenin	15,27	CREB-binding_protein	31,51	beta-catenin	CREB-binding protein	1499	1387	Gene	Gene	Acetylation|nmod|START_ENTITY Acetylation|nmod|END_ENTITY	Acetylation of beta-catenin by CREB-binding_protein -LRB- CBP -RRB- .
10671680	0	beta-catenin	35,47	CTNNB1	27,33	beta-catenin	CTNNB1	1499	1499	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutational analysis of the CTNNB1 -LRB- beta-catenin -RRB- gene in human endometrial_cancer : frequent mutations at codon 34 that cause nuclear accumulation .
15609344	0	beta-catenin	0,12	CTNNB1	14,20	beta-catenin	CTNNB1	1499	1499	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	beta-catenin -LRB- CTNNB1 -RRB- gene amplification : a new mechanism of protein overexpression in cancer .
18832571	0	beta-catenin	26,38	CTNNB1	45,51	beta-catenin	CTNNB1	1499	1499	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Specific mutations in the beta-catenin gene -LRB- CTNNB1 -RRB- correlate with local recurrence in sporadic_desmoid_tumors .
7736793	0	beta-catenin	24,36	CTNNB1	43,49	beta-catenin	CTNNB1	1499	1499	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human beta-catenin gene -LRB- CTNNB1 -RRB- to 3p22 -- > p21 .3 by fluorescence in situ hybridization .
7829088	0	beta-catenin	26,38	CTNNB1	45,51	beta-catenin	CTNNB1	1499	1499	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human beta-catenin gene -LRB- CTNNB1 -RRB- to 3p21 : a region implicated in tumor development .
8838805	0	beta-catenin	34,46	CTNNB1	53,59	beta-catenin	CTNNB1	1499	1499	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the human beta-catenin gene -LRB- CTNNB1 -RRB- .
14567991	0	beta-catenin	94,106	Carbonic_anhydrase_IX	0,21	beta-catenin	Carbonic anhydrase IX	477032(Tax:9615)	611933(Tax:9615)	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Carbonic_anhydrase_IX reduces E-cadherin-mediated adhesion of MDCK cells via interaction with beta-catenin .
12183362	0	beta-catenin	75,87	Casein_kinase_Iepsilon	45,67	beta-catenin	Casein kinase Iepsilon	31151(Tax:7227)	43673(Tax:7227)	Gene	Gene	complex|amod|START_ENTITY recruits|nmod|complex recruits|dobj|END_ENTITY	The ankyrin repeat protein Diversin recruits Casein_kinase_Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling .
10473551	0	beta-catenin	55,67	Cdc42	0,5	beta-catenin	Cdc42	12387(Tax:10090)	12540(Tax:10090)	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin .
12883492	0	beta-catenin	79,91	Cellular_retinol-binding_protein-1	0,34	beta-catenin	Cellular retinol-binding protein-1	1499	5947	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Cellular_retinol-binding_protein-1 in hepatocellular_carcinoma correlates with beta-catenin , Ki-67 index , and patient survival .
11867232	0	beta-catenin	22,34	Ctnnb1	41,47	beta-catenin	Ctnnb1	84353(Tax:10116)	84353(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequencing of the rat beta-catenin gene -LRB- Ctnnb1 -RRB- and mutational analysis of liver_tumors induced by 2-amino-3-methylimidazo -LSB- 4,5-f -RSB- quinoline .
14706452	0	beta-catenin	19,31	Ctnnb1	38,44	beta-catenin	Ctnnb1	84353(Tax:10116)	84353(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the rat beta-catenin gene -LRB- Ctnnb1 -RRB- promoter and its functional analysis compared with the Catnb and CTNNB1 promoters .
15063782	0	beta-catenin	65,77	Cyclin-dependent_kinase_2	0,25	beta-catenin	Cyclin-dependent kinase 2	1499	1017	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Cyclin-dependent_kinase_2 regulates the interaction of Axin with beta-catenin .
12081197	0	beta-catenin	73,85	Cyclin_D1	0,9	beta-catenin	Cyclin D1	1499	595	Gene	Gene	dysregulation|amod|START_ENTITY dependent|nmod|dysregulation dependent|nsubj|overexpression overexpression|amod|END_ENTITY	Cyclin_D1 overexpression in colorectal_carcinoma in vivo is dependent on beta-catenin protein dysregulation , but not k-ras mutation .
12183406	0	beta-catenin	40,52	Cyclin_D1	0,9	beta-catenin	Cyclin D1	12387(Tax:10090)	12443(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cyclin_D1 is not an essential target of beta-catenin signaling during intestinal tumorigenesis , but it may act as a modifier of disease severity in multiple_intestinal_neoplasia -LRB- Min -RRB- mice .
12663502	0	beta-catenin	42,54	Cyclin_D1	0,9	beta-catenin	Cyclin D1	12387(Tax:10090)	12443(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Cyclin_D1 over-expression correlates with beta-catenin activation , but not with H-ras mutations , and phosphorylation of Akt , GSK3_beta and ERK1/2 in mouse hepatic_carcinogenesis .
15946945	0	beta-catenin	40,52	Cyclin_D1	0,9	beta-catenin	Cyclin D1	12387(Tax:10090)	12443(Tax:10090)	Gene	Gene	Apc_loss|amod|START_ENTITY target|nmod|Apc_loss target|nsubj|END_ENTITY	Cyclin_D1 is not an immediate target of beta-catenin following Apc_loss in the intestine .
17145847	0	beta-catenin	60,72	Cyclooxygenase-2	0,16	beta-catenin	Cyclooxygenase-2	1499	5743	Gene	Gene	connection|amod|START_ENTITY chemoprevention|dep|connection chemoprevention|compound|END_ENTITY	Cyclooxygenase-2 and colorectal_cancer chemoprevention : the beta-catenin connection .
9309137	0	beta-catenin	6,18	DLG	20,23	beta-catenin	DLG	1499	32083(Tax:7227)	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- APC , beta-catenin , DLG -RSB- .
12907630	0	beta-catenin	111,123	Dishevelled	52,63	beta-catenin	Dishevelled	1499	8215	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|compound|END_ENTITY	Wnt pathway activation in mesothelioma : evidence of Dishevelled overexpression and transcriptional activity of beta-catenin .
10085258	0	beta-catenin	28,40	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	localization|amod|START_ENTITY prevents|dobj|localization prevents|nsubj|binding binding|compound|END_ENTITY	E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF -1 - mediated transactivation .
10571513	0	beta-catenin	35,47	E-cadherin	96,106	beta-catenin	E-cadherin	1499	999	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of E-cadherin , alpha - _ beta-catenin , and CD44V6 and the subcellular localization of E-cadherin and CD44V6 in normal epidermis and basal_cell_carcinoma .
10583557	0	beta-catenin	54,66	E-cadherin	32,42	beta-catenin	E-cadherin	1499	999	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of E-cadherin and alpha - / beta-catenin in adenoid_cystic_carcinoma .
10604738	0	beta-catenin	38,50	E-cadherin	77,87	beta-catenin	E-cadherin	1499	999	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Reduction in membranous expression of beta-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric_cancer .
10652321	0	beta-catenin	18,30	E-cadherin	49,59	beta-catenin	E-cadherin	1499	999	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Truncation of the beta-catenin binding domain of E-cadherin precedes epithelial apoptosis during prostate and mammary involution .
10830618	0	beta-catenin	44,56	E-cadherin	22,32	beta-catenin	E-cadherin	1499	999	Gene	Gene	localization|amod|START_ENTITY influences|dobj|localization influences|nsubj|END_ENTITY	Tumor-derived mutated E-cadherin influences beta-catenin localization and increases susceptibility to actin cytoskeletal changes induced by pervanadate .
10864814	0	beta-catenin	14,26	E-cadherin	146,156	beta-catenin	E-cadherin	1499	999	Gene	Gene	mRNA|amod|START_ENTITY Regulation|nmod|mRNA cytotrophoblasts|nsubj|Regulation cytotrophoblasts|xcomp|undergoing undergoing|advcl|vitro vitro|dep|correlation correlation|nmod|expression expression|amod|END_ENTITY	Regulation of beta-catenin mRNA and protein levels in human villous cytotrophoblasts undergoing aggregation and fusion in vitro : correlation with E-cadherin expression .
11024053	0	beta-catenin	116,128	E-cadherin	58,68	beta-catenin	E-cadherin	12387(Tax:10090)	12550(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY down-regulates|dobj|phosphorylation down-regulates|nsubj|addition addition|acl|bisecting bisecting|nmod|END_ENTITY	The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin .
11179484	0	beta-catenin	30,42	E-cadherin	10,20	beta-catenin	E-cadherin	1499	999	Gene	Gene	localization|amod|START_ENTITY augments|dobj|localization augments|nsubj|END_ENTITY	Decreased E-cadherin augments beta-catenin nuclear localization : studies in breast_cancer cell lines .
11205306	0	beta-catenin	32,44	E-cadherin	20,30	beta-catenin	E-cadherin	12387(Tax:10090)	12550(Tax:10090)	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of E-cadherin , beta-catenin , P120ctn in patients with transitional cell bladder_cancer .
11211307	0	beta-catenin	24,36	E-cadherin	63,73	beta-catenin	E-cadherin	1499	999	Gene	Gene	distribution|nmod|START_ENTITY distribution|amod|END_ENTITY	Altered distribution of beta-catenin , and its binding proteins E-cadherin and APC , in ulcerative_colitis-related colorectal_cancers .
11381089	0	beta-catenin	60,72	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner .
11564756	0	beta-catenin	71,83	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	activity|amod|START_ENTITY modulating|dobj|activity regulates|advcl|modulating regulates|nsubj|END_ENTITY	E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity .
11710913	0	beta-catenin	47,59	E-cadherin	114,124	beta-catenin	E-cadherin	1499	999	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|nmod|END_ENTITY	Tyrosine phosphorylation of human keratinocyte beta-catenin and plakoglobin reversibly regulates their binding to E-cadherin and alpha-catenin .
12507936	0	beta-catenin	66,78	E-cadherin	99,109	beta-catenin	E-cadherin	12387(Tax:10090)	12550(Tax:10090)	Gene	Gene	dissociation|nmod|START_ENTITY mediate|dobj|dissociation mediate|nmod|END_ENTITY	Matrix metalloproteinase -LRB- s -RRB- mediate -LRB- s -RRB- NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF -1 complex .
12786894	0	beta-catenin	28,40	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	alterations|amod|START_ENTITY loss|nmod|alterations loss|amod|END_ENTITY	E-cadherin loss rather than beta-catenin alterations is a common feature of poorly differentiated thyroid_carcinomas .
12839684	0	beta-catenin	62,74	E-cadherin	14,24	beta-catenin	E-cadherin	1499	999	Gene	Gene	methylation|nmod|START_ENTITY methylation|amod|END_ENTITY	-LSB- Influence of E-cadherin promoter methylation and mutation of beta-catenin on invasion and metastasis of nasopharyngeal_carcinoma cells -RSB- .
14623871	0	beta-catenin	88,100	E-cadherin	18,28	beta-catenin	E-cadherin	1499	999	Gene	Gene	signaling|amod|START_ENTITY roles|nmod|signaling Autoregulation|dep|roles Autoregulation|nmod|expression expression|amod|END_ENTITY	Autoregulation of E-cadherin expression by cadherin-cadherin interactions : the roles of beta-catenin signaling , Slug , and MAPK .
15328184	0	beta-catenin	112,124	E-cadherin	68,78	beta-catenin	E-cadherin	1499	999	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Invasion and metastasis of oral_cancer cells require methylation of E-cadherin and/or degradation of membranous beta-catenin .
15943787	0	beta-catenin	28,40	E-cadherin	79,89	beta-catenin	E-cadherin	1499	999	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|expression expression|nmod|END_ENTITY	Accumulation of cytoplasmic beta-catenin correlates with reduced expression of E-cadherin , but not with phosphorylated Akt in esophageal_squamous_cell_carcinoma : immunohistochemical study .
16132582	0	beta-catenin	108,120	E-cadherin	28,38	beta-catenin	E-cadherin	1499	999	Gene	Gene	fate|nmod|START_ENTITY determining|dobj|fate Wnt|acl|determining cross-talk|nmod|Wnt loss|dep|cross-talk loss|nmod|END_ENTITY	Frequent loss of membranous E-cadherin in gastric_cancers : A cross-talk with Wnt in determining the fate of beta-catenin .
16204054	0	beta-catenin	45,57	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	association|nmod|START_ENTITY regulates|dobj|association regulates|nsubj|END_ENTITY	E-cadherin regulates the association between beta-catenin and actinin-4 .
16224588	0	beta-catenin	26,38	E-cadherin	14,24	beta-catenin	E-cadherin	1499	999	Gene	Gene	molecules|amod|START_ENTITY molecules|amod|END_ENTITY	Expression of E-cadherin , beta-catenin , and CD-44v6 cell adhesion molecules in primary tumors and metastases of colorectal_adenocarcinoma .
16399195	0	beta-catenin	29,41	E-cadherin	10,20	beta-catenin	E-cadherin	1499	999	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Decreased E-cadherin but not beta-catenin expression is associated with vascular invasion and decreased survival in head_and_neck_squamous_carcinomas .
16425303	0	beta-catenin	32,44	E-cadherin	20,30	beta-catenin	E-cadherin	1499	999	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Prognostic value of E-cadherin , beta-catenin , MMPs -LRB- 7 and 9 -RRB- , and TIMPs -LRB- 1 and 2 -RRB- in patients with colorectal_carcinoma .
16966438	0	beta-catenin	22,34	E-cadherin	36,46	beta-catenin	E-cadherin	1499	999	Gene	Gene	cycloxygenase-2|amod|START_ENTITY cycloxygenase-2|amod|END_ENTITY	Altered expression of beta-catenin , E-cadherin , cycloxygenase-2 , and p53 protein by ovine intestinal adenocarcinoma cells .
17535680	0	beta-catenin	60,72	E-cadherin	48,58	beta-catenin	E-cadherin	1499	999	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Unusual expression and molecular mechanisms of E-cadherin , beta-catenin in correlation with clinicopathologic parameters in neuroblastoma -RSB- .
17908479	0	beta-catenin	26,38	E-cadherin	14,24	beta-catenin	E-cadherin	1499	999	Gene	Gene	cathepsin_D|amod|START_ENTITY Expression|amod|cathepsin_D Expression|nmod|END_ENTITY	Expression of E-cadherin , beta-catenin , cathepsin_D , gelatinases and their inhibitors in invasive_ductal_breast_carcinomas .
17959228	0	beta-catenin	57,69	E-cadherin	8,18	beta-catenin	E-cadherin	1499	999	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas .
18083766	0	beta-catenin	145,157	E-cadherin	12,22	beta-catenin	E-cadherin	477032(Tax:9615)	442858(Tax:9615)	Gene	Gene	mutations|nmod|START_ENTITY rescued|nmod|mutations rescued|nsubjpass|adhesion adhesion|compound|END_ENTITY	Compromised E-cadherin adhesion and epithelial barrier function with activation of G protein-coupled receptors is rescued by Y-to-F mutations in beta-catenin .
18553167	0	beta-catenin	47,59	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	accumulation|amod|START_ENTITY regulates|dobj|accumulation regulates|nsubj|fucosylation fucosylation|amod|END_ENTITY	E-cadherin core fucosylation regulates nuclear beta-catenin accumulation in lung_cancer cells .
18565826	0	beta-catenin	20,32	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	activity|amod|START_ENTITY controls|dobj|activity controls|nsubj|END_ENTITY	E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression .
18593713	0	beta-catenin	17,29	E-cadherin	41,51	beta-catenin	E-cadherin	1499	999	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nmod|complex complex|amod|END_ENTITY	Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion .
18655368	0	beta-catenin	20,32	E-cadherin	34,44	beta-catenin	E-cadherin	1499	999	Gene	Gene	Immunoexpression|nmod|START_ENTITY Immunoexpression|dep|complex complex|amod|END_ENTITY	Immunoexpression of beta-catenin -- E-cadherin complex in primary_serous_ovarian_tumors .
18674869	0	beta-catenin	12,24	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	E-cadherin , beta-catenin adhesion complex and relation to matrilysin expression in pT3 rectosigmoid_cancers .
20086044	0	beta-catenin	68,80	E-cadherin	32,42	beta-catenin	E-cadherin	1499	999	Gene	Gene	binding|nmod|START_ENTITY regulates|nmod|binding regulates|dobj|expression expression|amod|END_ENTITY	Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin .
21299609	0	beta-catenin	43,55	E-cadherin	24,34	beta-catenin	E-cadherin	1499	999	Gene	Gene	localization|amod|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of E-cadherin but not beta-catenin in human ovarian_granulosa_cell_tumours and normal ovarian follicles and ovarian_stroma .
7629993	0	beta-catenin	46,58	E-cadherin	16,26	beta-catenin	E-cadherin	1499	999	Gene	Gene	mutation|nmod|START_ENTITY due|nmod|mutation line|amod|due line|compound|END_ENTITY	-LSB- Dysfunction of E-cadherin due to mutation of beta-catenin in a scirrhous gastric_cancer cell line -RSB- .
7806582	0	beta-catenin	52,64	E-cadherin	0,10	beta-catenin	E-cadherin	1499	999	Gene	Gene	interaction|nmod|START_ENTITY compete|nmod|interaction compete|nsubj|END_ENTITY	E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton .
7954478	0	beta-catenin	12,24	E-cadherin	58,68	beta-catenin	E-cadherin	1499	999	Gene	Gene	disrupts|nsubj|START_ENTITY disrupts|dobj|interaction interaction|nmod|END_ENTITY	A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin : a cause of loss of intercellular adhesiveness in human cancer cell lines .
9759521	0	beta-catenin	101,113	E-cadherin	62,72	beta-catenin	E-cadherin	12387(Tax:10090)	12550(Tax:10090)	Gene	Gene	contribute|nsubj|START_ENTITY containing|ccomp|contribute complexes|acl|containing complexes|amod|END_ENTITY	Cadherin/catenin complexes in murine epidermal keratinocytes : E-cadherin complexes containing either beta-catenin or plakoglobin contribute to stable cell-cell contacts .
18794899	0	beta-catenin	15,27	E2F1	0,4	beta-catenin	E2F1	1499	1869	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8 .
12921570	0	beta-catenin	23,35	EP-CAM	15,21	beta-catenin	EP-CAM	1499	4072	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of EP-CAM , beta-catenin in the carcinogenesis of squamous_cell_carcinoma_of_uterine_cervix -RSB- .
12370240	0	beta-catenin	41,53	FHL2	21,25	beta-catenin	FHL2	12387(Tax:10090)	14200(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts .
12466281	0	beta-catenin	59,71	FHL2	34,38	beta-catenin	FHL2	1499	2274	Gene	Gene	coactivator|nmod|START_ENTITY END_ENTITY|nmod|coactivator	Identification of the LIM protein FHL2 as a coactivator of beta-catenin .
17851558	0	beta-catenin	15,27	FLT3	0,4	beta-catenin	FLT3	1499	2322	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	FLT3 regulates beta-catenin tyrosine phosphorylation , nuclear localization , and transcriptional activity in acute_myeloid_leukemia cells .
15649459	0	beta-catenin	31,43	Frzb	0,4	beta-catenin	Frzb	395964(Tax:9031)	395545(Tax:9031)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development .
10511426	0	beta-catenin	24,36	GSK-3beta	91,100	beta-catenin	GSK-3beta	12387(Tax:10090)	56637(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY correlates|nsubj|localization correlates|nmod|levels levels|nmod|END_ENTITY	Nuclear localization of beta-catenin in adult mouse thalamus correlates with low levels of GSK-3beta .
10699468	0	beta-catenin	8,20	GSK-3beta	30,39	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	displays|amod|START_ENTITY displays|amod|END_ENTITY	Nuclear beta-catenin displays GSK-3beta - and APC-independent proteasome sensitivity in melanoma cells .
11226152	0	beta-catenin	18,30	GSK-3beta	82,91	beta-catenin	GSK-3beta	12387(Tax:10090)	56637(Tax:10090)	Gene	Gene	START_ENTITY|appos|hyperphosphorylation hyperphosphorylation|nmod|transgenic_mice transgenic_mice|amod|conditional conditional|amod|END_ENTITY	Decreased nuclear beta-catenin , tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic_mice .
11313952	0	beta-catenin	32,44	GSK-3beta	95,104	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	pathway|amod|START_ENTITY stimulate|dobj|pathway stimulate|nmod|cascades cascades|nmod|inhibition inhibition|compound|END_ENTITY	Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation .
11738041	0	beta-catenin	92,104	GSK-3beta	32,41	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	phosphorylation|amod|START_ENTITY inhibits|dobj|phosphorylation peptide|acl:relcl|inhibits complexed|nmod|peptide complexed|nsubj|structure structure|nmod|END_ENTITY	The structure of phosphorylated GSK-3beta complexed with a peptide , FRATtide , that inhibits beta-catenin phosphorylation .
12969793	0	beta-catenin	44,56	GSK-3beta	0,9	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular_carcinoma .
16039586	0	beta-catenin	91,103	GSK-3beta	31,40	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	upregulation|nmod|START_ENTITY resulting|nmod|upregulation inactivation|acl|resulting primes|nmod|inactivation primes|dobj|END_ENTITY	Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin .
17968317	0	beta-catenin	21,33	GSK-3beta	57,66	beta-catenin	GSK-3beta	31151(Tax:7227)	31248(Tax:7227)	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nmod|absence absence|nmod|END_ENTITY	Human APC sequesters beta-catenin even in the absence of GSK-3beta in a Drosophila model .
18223684	0	beta-catenin	69,81	GSK-3beta	8,17	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	manner|amod|START_ENTITY signalling|nmod|manner Wnt|acl|signalling inhibits|dobj|Wnt inhibits|nsubj|END_ENTITY	Nuclear GSK-3beta inhibits the canonical Wnt signalling pathway in a beta-catenin phosphorylation-independent manner .
18346908	0	beta-catenin	32,44	GSK-3beta	22,31	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	pathway|amod|START_ENTITY activation|dep|pathway targets|parataxis|activation targets|dobj|END_ENTITY	TGF-beta1 targets the GSK-3beta / beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts .
18425851	0	beta-catenin	47,59	GSK-3beta	0,9	beta-catenin	GSK-3beta	399274(Tax:8355)	399097(Tax:8355)	Gene	Gene	effects|amod|START_ENTITY regions|nmod|effects regions|amod|END_ENTITY	GSK-3beta and alpha-catenin binding regions of beta-catenin exert opposing effects on the terminal ventral optic axonal projection .
18552505	0	beta-catenin	68,80	GSK-3beta	58,67	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	cascade|amod|START_ENTITY cascade|compound|END_ENTITY	HBx inhibits the growth of CCL13-HBX-stable cells via the GSK-3beta / beta-catenin cascade .
19228266	0	beta-catenin	136,148	GSK-3beta	54,63	beta-catenin	GSK-3beta	1499	2932	Gene	Gene	effects|nmod|START_ENTITY avoiding|dobj|effects insulin-sensitizer|acl|avoiding acts|nmod|insulin-sensitizer acts|nsubj|4-Aminoethylamino-emodin 4-Aminoethylamino-emodin|dep|inhibitor inhibitor|nmod|END_ENTITY	4-Aminoethylamino-emodin -- a novel potent inhibitor of GSK-3beta -- acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin .
19303025	0	beta-catenin	41,53	GSK-3beta	62,71	beta-catenin	GSK-3beta	12387(Tax:10090)	56637(Tax:10090)	Gene	Gene	accumulates|dobj|START_ENTITY accumulates|nmod|END_ENTITY	Caffeic_acid_phenethyl_ester accumulates beta-catenin through GSK-3beta and participates in proliferation through mTOR in C2C12 cells .
22672822	0	beta-catenin	90,102	GSK-3beta	14,23	beta-catenin	GSK-3beta	12387(Tax:10090)	56637(Tax:10090)	Gene	Gene	START_ENTITY|dep|ameliorates ameliorates|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of GSK-3beta ameliorates hepatic_ischemia-reperfusion injury through GSK-3beta / beta-catenin signaling pathway in mice .
22672822	0	beta-catenin	90,102	GSK-3beta	80,89	beta-catenin	GSK-3beta	12387(Tax:10090)	56637(Tax:10090)	Gene	Gene	START_ENTITY|dep|ameliorates ameliorates|nmod|END_ENTITY	Inhibition of GSK-3beta ameliorates hepatic_ischemia-reperfusion injury through GSK-3beta / beta-catenin signaling pathway in mice .
19293931	0	beta-catenin	38,50	GSK3	14,18	beta-catenin	GSK3	1499	399097(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6 .
19675674	0	beta-catenin	38,50	GSK3beta	0,8	beta-catenin	GSK3beta	1499	2932	Gene	Gene	inhibition|amod|START_ENTITY involved|nmod|inhibition involved|nsubjpass|END_ENTITY	GSK3beta is involved in JNK2-mediated beta-catenin inhibition .
15374939	0	beta-catenin	39,51	Galectin-3	0,10	beta-catenin	Galectin-3	1499	3958	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Galectin-3 , a novel binding partner of beta-catenin .
19112489	0	beta-catenin	25,37	Gata3	0,5	beta-catenin	Gata3	1499	2625	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction .
20079187	0	beta-catenin	15,27	Glut-1	29,35	beta-catenin	Glut-1	1499	6513	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	-LSB- Expression of beta-catenin , Glut-1 , PTEN proteins in uterine endometrioid_adenocarcinoma and its precursor lesions -RSB- .
16288908	0	beta-catenin	31,43	Glycogen_synthase_kinase-3beta	0,30	beta-catenin	Glycogen synthase kinase-3beta	84353(Tax:10116)	84027(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Glycogen_synthase_kinase-3beta / beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF , Bcl-2 and survivin expression in rat ischemic preconditioned myocardium .
18615589	0	beta-catenin	82,94	Glycogen_synthase_kinase-3beta	0,30	beta-catenin	Glycogen synthase kinase-3beta	1499	2932	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta regulates DeltaNp63 gene transcription through the beta-catenin signaling pathway .
11929826	0	beta-catenin	74,86	Hepatocyte_growth_factor	0,24	beta-catenin	Hepatocyte growth factor	84353(Tax:10116)	24446(Tax:10116)	Gene	Gene	translocation|nmod|START_ENTITY induces|dobj|translocation induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes .
18245266	0	beta-catenin	67,79	Hepatocyte_growth_factor	0,24	beta-catenin	Hepatocyte growth factor	1499	3082	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor regulates cyclooxygenase-2 expression via beta-catenin , Akt , and p42/p44 _ MAPK in human bronchial epithelial cells .
16936074	0	beta-catenin	14,26	Hex	0,3	beta-catenin	Hex	399274(Tax:8355)	373590(Tax:8355)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal .
20307497	0	beta-catenin	57,69	Homeodomain-interacting_protein_kinase_2	0,40	beta-catenin	Homeodomain-interacting protein kinase 2	12387(Tax:10090)	15258(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- targets beta-catenin for phosphorylation and proteasomal degradation .
15148409	0	beta-catenin	47,59	ICAT	79,83	beta-catenin	ICAT	1499	56998	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor -LRB- ICAT -RRB- , a negative regulator of Wnt signaling .
16616828	0	beta-catenin	30,42	IKKalpha	0,8	beta-catenin	IKKalpha	1499	1147	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways .
17255093	0	beta-catenin	48,60	IQ-domain_GTPase-activating_protein_1	0,37	beta-catenin	IQ-domain GTPase-activating protein 1	1499	8826	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IQ-domain_GTPase-activating_protein_1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous_polyposis_coli .
17060633	0	beta-catenin	47,59	JNK	25,28	beta-catenin	JNK	399274(Tax:8355)	379876(Tax:8355)	Gene	Gene	accumulation|amod|START_ENTITY prevents|dobj|accumulation prevents|nsubj|Jun_NH2-terminal_kinase Jun_NH2-terminal_kinase|appos|END_ENTITY	Jun_NH2-terminal_kinase -LRB- JNK -RRB- prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos .
19667122	0	beta-catenin	19,31	JNK	0,3	beta-catenin	JNK	1499	5599	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	JNK phosphorylates beta-catenin and regulates adherens junctions .
10330485	0	beta-catenin	109,121	LEF-1	103,108	beta-catenin	LEF-1	399274(Tax:8355)	779101(Tax:8355)	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1 / beta-catenin complex in Xenopus_laevis .
10330485	0	beta-catenin	41,53	LEF-1	103,108	beta-catenin	LEF-1	399274(Tax:8355)	779101(Tax:8355)	Gene	Gene	domain|nmod|START_ENTITY necessary|nsubj|domain necessary|advcl|signaling signaling|nmod|complex complex|compound|END_ENTITY	The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the LEF-1 / beta-catenin complex in Xenopus_laevis .
10966653	0	beta-catenin	13,25	LEF-1	48,53	beta-catenin	LEF-1	1499	51176	Gene	Gene	spots|nmod|START_ENTITY spots|nmod|interactions interactions|nmod|END_ENTITY	Hot spots in beta-catenin for interactions with LEF-1 , conductin and APC .
11029052	0	beta-catenin	18,30	LEF-1	98,103	beta-catenin	LEF-1	1499	51176	Gene	Gene	Overexpression|nmod|START_ENTITY induces|nsubj|Overexpression induces|xcomp|independent independent|nmod|function function|nmod|END_ENTITY	Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators .
11913959	0	beta-catenin	124,136	LEF-1	63,68	beta-catenin	LEF-1	12387(Tax:10090)	16842(Tax:10090)	Gene	Gene	dependent|advcl|START_ENTITY dependent|advmod|END_ENTITY	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
11913959	0	beta-catenin	124,136	LEF-1	86,91	beta-catenin	LEF-1	12387(Tax:10090)	16842(Tax:10090)	Gene	Gene	START_ENTITY|dep|import import|compound|END_ENTITY	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
11913959	0	beta-catenin	47,59	LEF-1	63,68	beta-catenin	LEF-1	12387(Tax:10090)	16842(Tax:10090)	Gene	Gene	import|nmod|START_ENTITY dependent|nsubj|import dependent|advmod|END_ENTITY	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
11913959	0	beta-catenin	47,59	LEF-1	86,91	beta-catenin	LEF-1	12387(Tax:10090)	16842(Tax:10090)	Gene	Gene	import|nmod|START_ENTITY dependent|nsubj|import dependent|advcl|beta-catenin beta-catenin|dep|import import|compound|END_ENTITY	New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent , while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities .
12052822	0	beta-catenin	7,19	LEF-1	61,66	beta-catenin	LEF-1	1499	51176	Gene	Gene	signaling|amod|START_ENTITY induces|nsubj|signaling induces|nmod|promoter promoter|compound|END_ENTITY	Wnt-3A / beta-catenin signaling induces transcription from the LEF-1 promoter .
16378739	0	beta-catenin	80,92	LEF-1	14,19	beta-catenin	LEF-1	1499	51176	Gene	Gene	patterns|nmod|START_ENTITY display|dobj|patterns display|nsubj|proteins proteins|compound|END_ENTITY	Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells .
8757136	0	beta-catenin	26,38	LEF-1	69,74	beta-catenin	LEF-1	31151(Tax:7227)	51176	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of beta-catenin with the transcription factor LEF-1 .
8892228	0	beta-catenin	24,36	LEF-1	78,83	beta-catenin	LEF-1	12387(Tax:10090)	16842(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of beta-catenin by interaction with transcription factor LEF-1 .
9671490	0	beta-catenin	102,114	LEF-1	44,49	beta-catenin	LEF-1	12387(Tax:10090)	16842(Tax:10090)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|regulation regulation|nmod|END_ENTITY	Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin .
11854293	0	beta-catenin	135,147	Lef-1	129,134	beta-catenin	Lef-1	12387(Tax:10090)	16842(Tax:10090)	Gene	Gene	START_ENTITY|dep|perturbed perturbed|nmod|stimulation stimulation|nmod|END_ENTITY	Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1 / beta-catenin signaling .
20195621	0	beta-catenin	89,101	Lgr5	14,18	beta-catenin	Lgr5	1499	8549	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Lgr5 in human colorectal_carcinogenesis and its potential correlation with beta-catenin .
10772923	0	beta-catenin	22,34	MAGI-1	0,6	beta-catenin	MAGI-1	477032(Tax:9615)	476565(Tax:9615)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures .
24824780	0	beta-catenin	13,25	MCC	0,3	beta-catenin	MCC	12387(Tax:10090)	328949(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm .
12907143	0	beta-catenin	31,43	MDA-7	0,5	beta-catenin	MDA-7	1499	11009	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast_and_lung_tumor cells .
23256367	0	beta-catenin	41,53	MMP-7	55,60	beta-catenin	MMP-7	84353(Tax:10116)	25335(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Influence of Bushen Huoxue decoction on beta-catenin , MMP-7 of synoviocytes in rats with knee_osteoarthritis -RSB- .
17000761	0	beta-catenin	71,83	Mitf	51,55	beta-catenin	Mitf	1499	4286	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The microphthalmia-associated transcription factor Mitf interacts with beta-catenin to determine target gene expression .
15723280	0	beta-catenin	36,48	N-cadherin	0,10	beta-catenin	N-cadherin	12387(Tax:10090)	12558(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY distribution|amod|END_ENTITY	N-cadherin mediated distribution of beta-catenin alters MAP kinase and BMP-2 signaling on chondrogenesis-related gene expression .
16707106	0	beta-catenin	33,45	N-cadherin	70,80	beta-catenin	N-cadherin	1499	1000	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin .
19401766	0	beta-catenin	51,63	N-cadherin	32,42	beta-catenin	N-cadherin	1499	1000	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Non-canonical Wnt signaling and N-cadherin related beta-catenin signaling play a role in mechanically induced osteogenic cell fate .
19479054	0	beta-catenin	35,47	NKX2-5	0,6	beta-catenin	NKX2-5	1499	1482	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes .
19850036	0	beta-catenin	20,32	Osteopontin	0,11	beta-catenin	Osteopontin	1499	6696	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Osteopontin induces beta-catenin signaling through activation of Akt in prostate_cancer cells .
12297840	0	beta-catenin	48,60	P53	0,3	beta-catenin	P53	1499	7157	Gene	Gene	mutations|amod|START_ENTITY gene|dep|mutations gene|compound|END_ENTITY	P53 gene and Wnt signaling in benign neoplasms : beta-catenin mutations in hepatic adenoma but not in focal_nodular_hyperplasia .
12439747	0	beta-catenin	37,49	P53	0,3	beta-catenin	P53	1499	7157	Gene	Gene	accumulation|amod|START_ENTITY source|nmod|accumulation mutation|nmod|source mutation|nsubj|END_ENTITY	P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells .
16434961	0	beta-catenin	36,48	P53	0,3	beta-catenin	P53	12387(Tax:10090)	22060(Tax:10090)	Gene	Gene	initiation|amod|START_ENTITY determine|nmod|initiation determine|nsubj|levels levels|compound|END_ENTITY	P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells .
18515095	0	beta-catenin	20,32	PAK1	0,4	beta-catenin	PAK1	1499	5058	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins .
12646189	0	beta-catenin	17,29	PECAM-1	0,7	beta-catenin	PECAM-1	1499	5175	Gene	Gene	accumulation|amod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	PECAM-1 promotes beta-catenin accumulation and stimulates endothelial cell proliferation .
12384561	0	beta-catenin	24,36	PML	0,3	beta-catenin	PML	1499	5371	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	PML is a target gene of beta-catenin and plakoglobin , and coactivates beta-catenin-mediated transcription .
20303941	0	beta-catenin	14,26	PPAR_gamma	40,50	beta-catenin	PPAR gamma	1499	5468	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Repression of beta-catenin signaling by PPAR_gamma ligands .
20079187	0	beta-catenin	15,27	PTEN	37,41	beta-catenin	PTEN	1499	5728	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	-LSB- Expression of beta-catenin , Glut-1 , PTEN proteins in uterine endometrioid_adenocarcinoma and its precursor lesions -RSB- .
11533658	0	beta-catenin	56,68	Pin1	0,4	beta-catenin	Pin1	1499	5300	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC .
19001871	0	beta-catenin	18,30	Polo-like_kinase_1	55,73	beta-catenin	Polo-like kinase 1	1499	5347	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of beta-catenin as a novel substrate of Polo-like_kinase_1 .
18632682	0	beta-catenin	45,57	Polycystin-1	0,12	beta-catenin	Polycystin-1	1499	5310	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling .
11606587	0	beta-catenin	37,49	Presenilin_1	0,12	beta-catenin	Presenilin 1	1499	5663	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Presenilin_1 independently regulates beta-catenin stability and transcriptional activity .
15117735	0	beta-catenin	11,23	R-cadherin	0,10	beta-catenin	R-cadherin	1499	1002	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	R-cadherin : beta-catenin complex and its association with vascular smooth muscle cell proliferation .
16294273	0	beta-catenin	85,97	RANKL	112,117	beta-catenin	RANKL	12387(Tax:10090)	21943(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Dominant negative N-cadherin inhibits osteoclast differentiation by interfering with beta-catenin regulation of RANKL , independent of cell-cell adhesion .
17050667	0	beta-catenin	32,44	Rad6B	62,67	beta-catenin	Rad6B	1499	7320	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Essential role of T-cell_factor / beta-catenin in regulation of Rad6B : a potential mechanism for Rad6B overexpression in breast_cancer cells .
20028760	0	beta-catenin	16,28	Rap1	0,4	beta-catenin	Rap1	1499	5906	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous_cell_carcinoma of the head_and_neck .
18250098	0	beta-catenin	14,26	Rspo1	40,45	beta-catenin	Rspo1	1499	284654	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary .
20126258	0	beta-catenin	32,44	SATB1	17,22	beta-catenin	SATB1	1499	6304	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Global regulator SATB1 recruits beta-catenin and regulates T -LRB- H -RRB- 2 differentiation in Wnt-dependent manner .
12571228	0	beta-catenin	23,35	SHP-1	70,75	beta-catenin	SHP-1	1499	5777	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of beta-catenin signaling by tyrosine phosphatase SHP-1 in intestinal epithelial cells .
15326481	0	beta-catenin	94,106	Siah-1L	0,7	beta-catenin	Siah-1L	1499	340571	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Siah-1L , a novel transcript variant belonging to the human Siah family of proteins , regulates beta-catenin activity in a p53-dependent manner .
18611862	0	beta-catenin	56,68	Slit-2	0,6	beta-catenin	Slit-2	12387(Tax:10090)	20563(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY induces|advcl|regulating induces|nsubj|END_ENTITY	Slit-2 induces a tumor-suppressive effect by regulating beta-catenin in breast_cancer cells .
18593713	0	beta-catenin	17,29	Smad7	0,5	beta-catenin	Smad7	1499	4092	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion .
17297467	0	beta-catenin	71,83	Snail	18,23	beta-catenin	Snail	12387(Tax:10090)	20613(Tax:10090)	Gene	Gene	promote|nmod|START_ENTITY acts|xcomp|promote acts|nmod|END_ENTITY	Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin .
18469861	0	beta-catenin	61,73	Snail	0,5	beta-catenin	Snail	1499	6615	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Snail promotes Wnt target gene expression and interacts with beta-catenin .
15898100	0	beta-catenin	70,82	Src	30,33	beta-catenin	Src	1499	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells .
15923620	0	beta-catenin	38,50	Src	7,10	beta-catenin	Src	1499	6714	Gene	Gene	expression|nmod|START_ENTITY elevates|dobj|expression elevates|nsubj|END_ENTITY	Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation .
10896949	0	beta-catenin	23,35	T-cell_factor	88,101	beta-catenin	T-cell factor	1499	3172	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|preventing preventing|dobj|formation formation|nmod|complex complex|compound|END_ENTITY	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
10896949	0	beta-catenin	75,87	T-cell_factor	88,101	beta-catenin	T-cell factor	1499	3172	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
17050667	0	beta-catenin	32,44	T-cell_factor	18,31	beta-catenin	T-cell factor	1499	3172	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Essential role of T-cell_factor / beta-catenin in regulation of Rad6B : a potential mechanism for Rad6B overexpression in breast_cancer cells .
15940627	0	beta-catenin	78,90	T-cell_factor-4	62,77	beta-catenin	T-cell factor-4	1499	6934	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Poly -LRB- ADP-ribose -RRB- _ polymerase-1 is a component of the oncogenic T-cell_factor-4 / beta-catenin complex .
11309309	0	beta-catenin	19,31	TCF	32,35	beta-catenin	TCF	1499	3172	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation .
15514942	0	beta-catenin	83,95	TCF	97,100	beta-catenin	TCF	1499	3172	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Overexpression of human pituitary_tumor_transforming_gene -LRB- hPTTG -RRB- , is regulated by beta-catenin / TCF pathway in human esophageal_squamous_cell_carcinoma .
15525529	0	beta-catenin	79,91	TCF	97,100	beta-catenin	TCF	1499	3172	Gene	Gene	divert|dobj|START_ENTITY divert|nmod|END_ENTITY	The APC_tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF .
20348951	0	beta-catenin	61,73	TCF	13,16	beta-catenin	TCF	1499	3172	Gene	Gene	expression|amod|START_ENTITY blocking|dobj|expression signaling|advcl|blocking signaling|nsubj|END_ENTITY	PKG inhibits TCF signaling in colon_cancer cells by blocking beta-catenin expression and activating FOXO4 .
12861022	0	beta-catenin	75,87	TCF-4	52,57	beta-catenin	TCF-4	12387(Tax:10090)	21413(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|factor factor|appos|isoform isoform|nmod|END_ENTITY	T-cell factor 4N -LRB- TCF-4N -RRB- , a novel isoform of mouse TCF-4 , synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic_factor_1 transcription factors .
15525634	0	beta-catenin	79,91	TCF-4	0,5	beta-catenin	TCF-4	1499	6925	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen_synthase_kinase-3beta .
20122174	0	beta-catenin	43,55	TCF-4	19,24	beta-catenin	TCF-4	1499	6934	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Axin downregulates TCF-4 transcription via beta-catenin , but not p53 , and inhibits the proliferation and invasion of lung_cancer cells .
9784592	0	beta-catenin	12,24	TCF-4	0,5	beta-catenin	TCF-4	12387(Tax:10090)	21413(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs .
12944908	0	beta-catenin	100,112	Tcf	144,147	beta-catenin	Tcf	1499	3172	Gene	Gene	factor|nmod|START_ENTITY localization|nmod|factor localization|dep|means means|nmod|inhibition inhibition|nmod|END_ENTITY	Functional localization and competition between the androgen_receptor and T-cell factor for nuclear beta-catenin : a means for inhibition of the Tcf signaling axis .
15457508	0	beta-catenin	45,57	Tcf	0,3	beta-catenin	Tcf	1499	3172	Gene	Gene	responsiveness|amod|START_ENTITY determines|dobj|responsiveness determines|nsubj|sequence sequence|compound|END_ENTITY	Tcf binding sequence and position determines beta-catenin and Lef-1 responsiveness of MMP-7 promoters .
11711551	0	beta-catenin	70,82	Tcf-4	27,32	beta-catenin	Tcf-4	1499	6925	Gene	Gene	sites|nmod|START_ENTITY contains|dobj|sites contains|nsubj|END_ENTITY	The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin .
12657632	0	beta-catenin	43,55	Tcf4	13,17	beta-catenin	Tcf4	1499	6925	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Hot spots in Tcf4 for the interaction with beta-catenin .
10564161	0	beta-catenin	44,56	VEGF	0,4	beta-catenin	VEGF	539003(Tax:9913)	281572(Tax:9913)	Gene	Gene	dysfunction|amod|START_ENTITY phosphorylation|nmod|dysfunction stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	VEGF stimulates tyrosine phosphorylation of beta-catenin and small-pore endothelial barrier dysfunction .
16288908	0	beta-catenin	31,43	VEGF	118,122	beta-catenin	VEGF	84353(Tax:10116)	83785(Tax:10116)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|xcomp|signaling signaling|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	Glycogen_synthase_kinase-3beta / beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF , Bcl-2 and survivin expression in rat ischemic preconditioned myocardium .
19306293	0	beta-catenin	21,33	VEGF	37,41	beta-catenin	VEGF	1499	7422	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of beta-catenin in VEGF and histamine-induced MMP-2 production in microvascular endothelial cells .
20010698	0	beta-catenin	33,45	VEGF	19,23	beta-catenin	VEGF	12387(Tax:10090)	22339(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones .
15870927	0	beta-catenin	19,31	WNT-1	10,15	beta-catenin	WNT-1	1499	7471	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral_squamous_cell_carcinoma .
20107203	0	beta-catenin	62,74	WNT2	0,4	beta-catenin	WNT2	12387(Tax:10090)	22413(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	WNT2 regulates DNA synthesis in mouse granulosa cells through beta-catenin .
14666652	0	beta-catenin	115,127	WT1	71,74	beta-catenin	WT1	1499	7490	Gene	Gene	destabilization|nmod|START_ENTITY associated|nmod|destabilization associated|nsubjpass|Inhibition Inhibition|nmod|growth growth|nmod|END_ENTITY	Inhibition of breast_cancer cell growth by the Wilms ' _ tumor suppressor WT1 is associated with a destabilization of beta-catenin .
25331950	0	beta-catenin	69,81	WT1	25,28	beta-catenin	WT1	1499	7490	Gene	Gene	gene|amod|START_ENTITY silencing|nmod|gene suppresses|dobj|silencing suppresses|nsubj|suppressor suppressor|appos|END_ENTITY	Wilms_tumour suppressor , WT1 , suppresses epigenetic silencing of the beta-catenin gene .
17988238	0	beta-catenin	74,86	Wnt1	98,102	beta-catenin	Wnt1	84353(Tax:10116)	24881(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Differential activation of the calcium/protein kinase C and the canonical beta-catenin pathway by Wnt1 and Wnt7a produces opposite effects on cell proliferation in PC12 cells .
18403409	0	beta-catenin	25,37	Wt1	0,3	beta-catenin	Wt1	1499	7490	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Wt1 negatively regulates beta-catenin signaling during testis development .
10694436	0	beta-catenin	12,24	alpha-catenin	99,112	beta-catenin	alpha-catenin	1499	1495	Gene	Gene	aggregation|amod|START_ENTITY Analysis|nmod|aggregation Analysis|dep|import import|nmod|END_ENTITY	Analysis of beta-catenin aggregation and localization using GFP fusion proteins : nuclear import of alpha-catenin by the beta-catenin/Tcf complex .
10896949	0	beta-catenin	23,35	alpha-catenin	0,13	beta-catenin	alpha-catenin	1499	1495	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
10896949	0	beta-catenin	75,87	alpha-catenin	0,13	beta-catenin	alpha-catenin	1499	1495	Gene	Gene	complex|amod|START_ENTITY formation|nmod|complex preventing|dobj|formation signaling|advcl|preventing beta-catenin|acl|signaling inhibits|dobj|beta-catenin inhibits|nsubj|END_ENTITY	alpha-catenin inhibits beta-catenin signaling by preventing formation of a beta-catenin * T-cell_factor * DNA complex .
12432063	0	beta-catenin	49,61	alpha-catenin	67,80	beta-catenin	alpha-catenin	1499	1495	Gene	Gene	interaction|nmod|START_ENTITY regulates|dobj|interaction regulates|nmod|END_ENTITY	Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability .
15695815	0	beta-catenin	14,26	alpha-catenin	136,149	beta-catenin	alpha-catenin	1499	1495	Gene	Gene	signaling|amod|START_ENTITY Regulation|nmod|signaling Regulation|nmod|degradation degradation|nmod|END_ENTITY	Regulation of beta-catenin signaling and maintenance of chondrocyte differentiation by ubiquitin-independent proteasomal degradation of alpha-catenin .
9110993	0	beta-catenin	79,91	alpha-catenin	32,45	beta-catenin	alpha-catenin	1499	1495	Gene	Gene	involved|nmod|START_ENTITY involved|nsubj|Identification Identification|nmod|domain domain|nmod|END_ENTITY	Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin -LRB- gamma-catenin -RRB- .
9264463	0	beta-catenin	55,67	alpha-catenin	21,34	beta-catenin	alpha-catenin	1499	1495	Gene	Gene	binding|nmod|START_ENTITY mediates|xcomp|binding mediates|nsubj|domain domain|nmod|END_ENTITY	A specific domain in alpha-catenin mediates binding to beta-catenin or plakoglobin .
18397997	0	beta-catenin	49,61	alphaE-catenin	0,14	beta-catenin	alphaE-catenin	1499	1495	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	alphaE-catenin is not a significant regulator of beta-catenin signaling in the developing mammalian brain .
19389371	0	beta-catenin	84,96	alphaE-catenin	19,33	beta-catenin	alphaE-catenin	1499	1495	Gene	Gene	differentiation|nmod|START_ENTITY causes|dobj|differentiation causes|nsubj|reduction reduction|nmod|END_ENTITY	Focal reduction of alphaE-catenin causes premature differentiation and reduction of beta-catenin signaling during cortical development .
11856748	0	beta-catenin	34,46	androgen_receptor	4,21	beta-catenin	androgen receptor	1499	367	Gene	Gene	translocation|amod|START_ENTITY promote|dobj|translocation promote|nsubj|END_ENTITY	The androgen_receptor can promote beta-catenin nuclear translocation independently of adenomatous_polyposis_coli .
11916967	0	beta-catenin	44,56	androgen_receptor	9,26	beta-catenin	androgen receptor	1499	367	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Liganded androgen_receptor interaction with beta-catenin : nuclear co-localization and modulation of transcriptional activity in neuronal cells .
12944908	0	beta-catenin	100,112	androgen_receptor	52,69	beta-catenin	androgen receptor	1499	367	Gene	Gene	factor|nmod|START_ENTITY factor|compound|END_ENTITY	Functional localization and competition between the androgen_receptor and T-cell factor for nuclear beta-catenin : a means for inhibition of the Tcf signaling axis .
16141201	0	beta-catenin	15,27	androgen_receptor	80,97	beta-catenin	androgen receptor	1499	367	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of beta-catenin and TIF2/GRIP1 in transcriptional activation by the androgen_receptor .
16210377	0	beta-catenin	122,134	androgen_receptor	91,108	beta-catenin	androgen receptor	12387(Tax:10090)	11835(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY complex|compound|END_ENTITY	Testosterone inhibits adipogenic differentiation in 3T3-L1 cells : nuclear translocation of androgen_receptor complex with beta-catenin and T-cell_factor_4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors .
17653089	0	beta-catenin	61,73	androgen_receptor	28,45	beta-catenin	androgen receptor	1499	367	Gene	Gene	pathway|amod|START_ENTITY activation|nmod|pathway activation|nmod|END_ENTITY	Inappropriate activation of androgen_receptor by relaxin via beta-catenin pathway .
18948405	0	beta-catenin	91,103	androgen_receptor	72,89	beta-catenin	androgen receptor	12387(Tax:10090)	11835(Tax:10090)	Gene	Gene	factor-beta|compound|START_ENTITY signaling|nsubj|factor-beta Regulation|parataxis|signaling Regulation|dep|talk talk|nmod|END_ENTITY	Regulation of myogenic differentiation by androgens : cross talk between androgen_receptor / beta-catenin and follistatin/transforming growth factor-beta signaling pathways .
7876319	0	beta-catenin	59,71	armadillo	32,41	beta-catenin	armadillo	399274(Tax:8355)	31151(Tax:7227)	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Embryonic_axis induction by the armadillo repeat domain of beta-catenin : evidence for intracellular signaling .
10421629	0	beta-catenin	47,59	axin	33,37	beta-catenin	axin	1499	8312	Gene	Gene	releases|dobj|START_ENTITY releases|nsubj|dephosphorylation dephosphorylation|nmod|END_ENTITY	Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex .
10421629	0	beta-catenin	47,59	axin	69,73	beta-catenin	axin	1499	8312	Gene	Gene	releases|dobj|START_ENTITY releases|nmod|complex complex|compound|END_ENTITY	Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex .
10581160	0	beta-catenin	67,79	axin	35,39	beta-catenin	axin	1499	8312	Gene	Gene	expression|amod|START_ENTITY modulates|nmod|expression modulates|nsubj|site site|nmod|END_ENTITY	A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression .
12297048	0	beta-catenin	100,112	axin	77,81	beta-catenin	axin	1499	8312	Gene	Gene	activation|amod|START_ENTITY implications|nmod|activation phosphorylation|dep|implications phosphorylation|nmod|independent independent|nmod|END_ENTITY	Presenilin couples the paired phosphorylation of beta-catenin independent of axin : implications for beta-catenin activation in tumorigenesis .
12297048	0	beta-catenin	49,61	axin	77,81	beta-catenin	axin	1499	8312	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Presenilin couples the paired phosphorylation of beta-catenin independent of axin : implications for beta-catenin activation in tumorigenesis .
9501208	0	beta-catenin	12,24	axin	63,67	beta-catenin	axin	1499	8312	Gene	Gene	Bridging|nmod|START_ENTITY synthase|nsubj|Bridging synthase|nmod|END_ENTITY	Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription .
9554852	0	beta-catenin	59,71	axin	29,33	beta-catenin	axin	399274(Tax:8355)	398097(Tax:8355)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of an axin homolog , conductin , with beta-catenin , APC , and GSK3beta .
10074433	0	beta-catenin	59,71	beta-TrCP	18,27	beta-catenin	beta-TrCP	1499	8945	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell .
16153468	0	beta-catenin	121,133	beta-catenin	69,81	beta-catenin	beta-catenin	1499	1499	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Desmoplastic_fibroma of bone : an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin .
16153468	0	beta-catenin	69,81	beta-catenin	121,133	beta-catenin	beta-catenin	1499	1499	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Desmoplastic_fibroma of bone : an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin .
15017589	0	beta-catenin	62,74	c-Myc	76,81	beta-catenin	c-Myc	1499	4609	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical evaluation of adenomatous_polyposis_coli , beta-catenin , c-Myc , cyclin_D1 , p53 , and retinoblastoma protein expression in syndromic and sporadic fundic_gland_polyps .
18852287	0	beta-catenin	25,37	c-Myc	107,112	beta-catenin	c-Myc	1499	4609	Gene	Gene	sites|amod|START_ENTITY screen|nmod|sites identifies|nsubj|screen identifies|dobj|element element|acl:relcl|controls controls|dobj|expression expression|amod|END_ENTITY	A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression .
17136310	0	beta-catenin	41,53	c-myc	82,87	beta-catenin	c-myc	84353(Tax:10116)	24577(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells .
12417018	0	beta-catenin	34,46	casein_kinase_I_epsilon	50,73	beta-catenin	casein kinase I epsilon	1499	102800317	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and regulation of beta-catenin by casein_kinase_I_epsilon .
9515794	0	beta-catenin	18,30	ctnnb1	32,38	beta-catenin	ctnnb1	84353(Tax:10116)	84353(Tax:10116)	Gene	Gene	mutations|amod|START_ENTITY mutations|amod|END_ENTITY	High frequency of beta-catenin -LRB- ctnnb1 -RRB- mutations in the colon_tumors induced by two heterocyclic_amines in the F344 rat .
14985333	0	beta-catenin	14,26	cyclin-dependent_kinase_2	58,83	beta-catenin	cyclin-dependent kinase 2	1499	1017	Gene	Gene	phosphorylation/degradation|amod|START_ENTITY Modulation|nmod|phosphorylation/degradation Modulation|nmod|END_ENTITY	Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent_kinase_2 .
17208333	0	beta-catenin	14,26	cyclin-dependent_kinase_6	30,55	beta-catenin	cyclin-dependent kinase 6	12387(Tax:10090)	12571(Tax:10090)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of beta-catenin by cyclin-dependent_kinase_6 in Wnt-stimulated cells .
11309340	0	beta-catenin	40,52	cyclin_D1	96,105	beta-catenin	cyclin D1	1499	595	Gene	Gene	gene|amod|START_ENTITY deletions|nmod|gene associated|nsubjpass|deletions associated|nmod|overexpression overexpression|nmod|END_ENTITY	Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin_D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma .
11592102	0	beta-catenin	0,12	cyclin_D1	48,57	beta-catenin	cyclin D1	1499	595	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|overexpression overexpression|amod|END_ENTITY	beta-catenin nuclear expression correlates with cyclin_D1 overexpression in sporadic_desmoid_tumours .
11836555	0	beta-catenin	89,101	cyclin_D1	24,33	beta-catenin	cyclin D1	1499	595	Gene	Gene	gene|amod|START_ENTITY Immunohistochemistry|nmod|gene Immunohistochemistry|nmod|END_ENTITY	Immunohistochemistry of cyclin_D1 and beta-catenin , and mutational analysis of exon 3 of beta-catenin gene in parathyroid_adenomas .
12878043	0	beta-catenin	24,36	cyclin_D1	46,55	beta-catenin	cyclin D1	12387(Tax:10090)	12443(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY Expression|nmod|targets Expression|appos|END_ENTITY	Expression of potential beta-catenin targets , cyclin_D1 , c-Jun , c-Myc , E-cadherin , and EGFR in chemically_induced_hepatocellular_neoplasms from B6C3F1 mice .
14666673	0	beta-catenin	24,36	cyclin_D1	74,83	beta-catenin	cyclin D1	1499	595	Gene	Gene	localization|nmod|START_ENTITY correlated|nsubjpass|localization correlated|nmod|expression expression|nmod|END_ENTITY	Nuclear localization of beta-catenin is correlated with the expression of cyclin_D1 in endometrial_carcinomas .
15017589	0	beta-catenin	62,74	cyclin_D1	83,92	beta-catenin	cyclin D1	1499	595	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical evaluation of adenomatous_polyposis_coli , beta-catenin , c-Myc , cyclin_D1 , p53 , and retinoblastoma protein expression in syndromic and sporadic fundic_gland_polyps .
15116100	0	beta-catenin	64,76	cyclin_D1	31,40	beta-catenin	cyclin D1	1499	595	Gene	Gene	pathways|amod|START_ENTITY involves|dobj|pathways involves|nsubj|activation activation|nmod|transcription transcription|amod|END_ENTITY	Gastrin-mediated activation of cyclin_D1 transcription involves beta-catenin and CREB pathways in gastric_cancer cells .
15791567	0	beta-catenin	9,21	cyclin_D1	102,111	beta-catenin	cyclin D1	1499	595	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|nmod|END_ENTITY	Abnormal beta-catenin expression in oral_cancer with no gene mutation : correlation with expression of cyclin_D1 and epidermal_growth_factor_receptor , Ki-67 labeling index , and clinicopathological features .
15946752	0	beta-catenin	0,12	cyclin_D1	41,50	beta-catenin	cyclin D1	84353(Tax:10116)	58919(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|promoter promoter|amod|END_ENTITY	beta-catenin signaling and regulation of cyclin_D1 promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl_oxidase .
16690606	0	beta-catenin	86,98	cyclin_D1	43,52	beta-catenin	cyclin D1	12387(Tax:10090)	12443(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|dobj|expression expression|amod|END_ENTITY	Transforming growth factor-beta stimulates cyclin_D1 expression through activation of beta-catenin signaling in chondrocytes .
16733209	0	beta-catenin	8,20	cyclin_D1	37,46	beta-catenin	cyclin D1	1499	595	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|expression expression|amod|END_ENTITY	Nuclear beta-catenin correlates with cyclin_D1 expression in spindle and pleomorphic_sarcomas but not in synovial_sarcoma .
17412698	0	beta-catenin	64,76	cyclin_D1	16,25	beta-catenin	cyclin D1	12387(Tax:10090)	12443(Tax:10090)	Gene	Gene	interacting|nmod|START_ENTITY suppresses|advcl|interacting suppresses|dobj|activity activity|amod|END_ENTITY	SOX6 suppresses cyclin_D1 promoter activity by interacting with beta-catenin and histone_deacetylase_1 , and its down-regulation induces pancreatic beta-cell proliferation .
20235220	0	beta-catenin	0,12	cyclin_D1	70,79	beta-catenin	cyclin D1	1499	595	Gene	Gene	mediates|nsubj|START_ENTITY mediates|xcomp|promote promote|dobj|expression expression|amod|END_ENTITY	beta-catenin mediates insulin-like growth factor-I actions to promote cyclin_D1 mRNA expression , cell proliferation and survival in oligodendroglial cultures .
17710160	0	beta-catenin	15,27	cyclooxygenase-2	46,62	beta-catenin	cyclooxygenase-2	1499	5743	Gene	Gene	localization|amod|START_ENTITY localization|nmod|expression expression|amod|END_ENTITY	Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype -LRB- CIMP -RRB- in colorectal_cancer .
17962194	0	beta-catenin	76,88	cyclooxygenase-2	40,56	beta-catenin	cyclooxygenase-2	1499	5743	Gene	Gene	protein|amod|START_ENTITY induces|nmod|protein induces|dobj|expression expression|amod|END_ENTITY	Proteinase-activated_receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic_AMP-response element-binding protein .
18245266	0	beta-catenin	67,79	cyclooxygenase-2	35,51	beta-catenin	cyclooxygenase-2	1499	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Hepatocyte_growth_factor regulates cyclooxygenase-2 expression via beta-catenin , Akt , and p42/p44 _ MAPK in human bronchial epithelial cells .
18751438	0	beta-catenin	56,68	cyclooxygenase-2	30,46	beta-catenin	cyclooxygenase-2	1499	5743	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Microvessel density -LRB- MVD -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- / beta-catenin interaction are associated with relapse in patients with transitional carcinoma receiving adjuvant chemotherapy with paclitaxel/carboplatin : a hellenic cooperative oncology group -LRB- HECOG -RRB- study .
21679035	0	beta-catenin	163,175	cyclooxygenase-2	132,148	beta-catenin	cyclooxygenase-2	12387(Tax:10090)	19225(Tax:10090)	Gene	Gene	localisation|amod|START_ENTITY localisation|amod|END_ENTITY	Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation .
16858403	0	beta-catenin	52,64	emerin	35,41	beta-catenin	emerin	1499	2010	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus .
14678957	0	beta-catenin	62,74	fibroblast_growth_factor-binding_protein	17,57	beta-catenin	fibroblast growth factor-binding protein	1499	9982	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of fibroblast_growth_factor-binding_protein , by beta-catenin during colon carcinogenesis .
10409747	0	beta-catenin	29,41	fibronectin	51,62	beta-catenin	fibronectin	399274(Tax:8355)	397744(Tax:8355)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	The Wnt/Wg signal transducer beta-catenin controls fibronectin expression .
11104755	0	beta-catenin	121,133	glycogen_synthase_kinase-3beta	18,48	beta-catenin	glycogen synthase kinase-3beta	1499	2932	Gene	Gene	signaling|amod|START_ENTITY separates|nmod|signaling separates|nsubj|Substitution Substitution|nmod|site site|amod|END_ENTITY	Substitution of a glycogen_synthase_kinase-3beta phosphorylation site in presenilin_1 separates presenilin function from beta-catenin signaling .
18957842	0	beta-catenin	144,156	glycogen_synthase_kinase-3beta	113,143	beta-catenin	glycogen synthase kinase-3beta	1499	2932	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|vitro vitro|nmod|/ /|amod|END_ENTITY	Lithium_chloride preconditioning optimizes skeletal myoblast functions for cellular cardiomyoplasty in vitro via glycogen_synthase_kinase-3beta / beta-catenin signaling .
19190323	0	beta-catenin	28,40	glycogen_synthase_kinase-3beta	117,147	beta-catenin	glycogen synthase kinase-3beta	1499	2932	Gene	Gene	accumulation|amod|START_ENTITY signaling|nsubj|accumulation signaling|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon_cancer cells by regulation of glycogen_synthase_kinase-3beta activity .
20623542	0	beta-catenin	104,116	glycogen_synthase_kinase-3beta	41,71	beta-catenin	glycogen synthase kinase-3beta	84353(Tax:10116)	84027(Tax:10116)	Gene	Gene	turnover|amod|START_ENTITY promotes|dobj|turnover complex|acl:relcl|promotes complex|amod|END_ENTITY	Delta-catenin/NPRAP : A new member of the glycogen_synthase_kinase-3beta signaling complex that promotes beta-catenin turnover in neurons .
18059173	0	beta-catenin	101,113	hADA2a	0,6	beta-catenin	hADA2a	1499	6871	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	hADA2a and hADA3 are required for acetylation , transcriptional activity and proliferative effects of beta-catenin .
21454484	0	beta-catenin	39,51	histone_deacetylase_5	70,91	beta-catenin	histone deacetylase 5	12387(Tax:10090)	15184(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	AMP-activated protein kinase regulates beta-catenin transcription via histone_deacetylase_5 .
18360690	0	beta-catenin	31,43	interleukin-13	13,27	beta-catenin	interleukin-13	1499	3596	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Influence of interleukin-13 on beta-catenin levels in eosinophilic chronic rhinosinusitis cell culture .
11267862	0	beta-catenin	28,40	interleukin_6	55,68	beta-catenin	interleukin 6	1499	3569	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Downregulation of wild-type beta-catenin expression by interleukin_6 in human hepatocarcinoma HepG2 cells : a possible role in the growth-regulatory effects of the cytokine ?
15239100	0	beta-catenin	85,97	leukocyte_cell-derived_chemotaxin_2	22,57	beta-catenin	leukocyte cell-derived chemotaxin 2	1499	3950	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Identification of the leukocyte_cell-derived_chemotaxin_2 as a direct target gene of beta-catenin in the liver .
10514384	0	beta-catenin	0,12	matrix_metalloproteinase-7	45,71	beta-catenin	matrix metalloproteinase-7	1499	4316	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	beta-catenin regulates the expression of the matrix_metalloproteinase-7 in human colorectal_cancer .
16158183	0	beta-catenin	133,145	matrix_metalloproteinase-7	82,108	beta-catenin	matrix metalloproteinase-7	1499	4316	Gene	Gene	immunoreactivity|amod|START_ENTITY associated|nmod|immunoreactivity END_ENTITY|acl|associated	A subset of high-grade pulmonary_neuroendocrine_carcinomas shows up-regulation of matrix_metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity , independent of EGFR and HER-2_gene_amplification or expression .
16804904	0	beta-catenin	103,115	matrix_metalloproteinase-7	27,53	beta-catenin	matrix metalloproteinase-7	1499	4316	Gene	Gene	expression|amod|START_ENTITY significance|nmod|expression significance|nmod|END_ENTITY	Prognostic significance of matrix_metalloproteinase-7 in epithelial_ovarian_cancer and its relation to beta-catenin expression .
1334250	0	beta-catenin	117,129	p120	0,4	beta-catenin	p120	1499	1500	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	p120 , a novel substrate of protein tyrosine kinase receptors and of p60v-src , is related to cadherin-binding factors beta-catenin , plakoglobin and armadillo .
16858682	0	beta-catenin	34,46	p16INK4A	13,21	beta-catenin	p16INK4A	1499	1029	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Induction Induction|nmod|END_ENTITY	Induction of p16INK4A mediated by beta-catenin in a TCF4-independent manner : implications for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial_carcinoma cells .
10357817	0	beta-catenin	7,19	p53	70,73	beta-catenin	p53	1499	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|accumulation accumulation|nmod|END_ENTITY	Excess beta-catenin promotes accumulation of transcriptionally active p53 .
10513218	0	beta-catenin	73,85	p53	154,157	beta-catenin	p53	1499	7157	Gene	Gene	atypia|nmod|START_ENTITY relationship|nmod|atypia relationship|dep|comparison comparison|nmod|that that|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The relationship between the histopathological atypia and expression of beta-catenin in colonic_neoplasms resected by endoscopy ; comparison with that of p53 protein -RSB- .
10851067	0	beta-catenin	79,91	p53	118,121	beta-catenin	p53	12387(Tax:10090)	22060(Tax:10090)	Gene	Gene	effect|amod|START_ENTITY effect|nmod|alleles alleles|nummod|END_ENTITY	Hepatocellular_carcinoma in WHV/N-myc 2 transgenic_mice : oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles .
11389839	0	beta-catenin	56,68	p53	91,94	beta-catenin	p53	1499	7157	Gene	Gene	degradation|amod|START_ENTITY degradation|acl|linked linked|nmod|responses responses|compound|END_ENTITY	Siah-1 , SIP , and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses .
11389840	0	beta-catenin	24,36	p53	65,68	beta-catenin	p53	1499	7157	Gene	Gene	pathway|amod|START_ENTITY pathway|acl|linking linking|dobj|END_ENTITY	Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous_polyposis_coli protein .
11532955	0	beta-catenin	12,24	p53	35,38	beta-catenin	p53	12387(Tax:10090)	22060(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Deregulated beta-catenin induces a p53 - and ARF-dependent growth arrest and cooperates with Ras in transformation .
15064706	0	beta-catenin	70,82	p53	34,37	beta-catenin	p53	1499	7157	Gene	Gene	phosphorylation|amod|START_ENTITY rate|nmod|phosphorylation changes|nmod|rate involves|dobj|changes involves|nsubj|Downregulation Downregulation|nmod|beta-catenin beta-catenin|nmod|END_ENTITY	Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics .
17622616	0	beta-catenin	101,113	p53	150,153	beta-catenin	p53	1499	7157	Gene	Gene	degradation|nmod|START_ENTITY affects|dobj|degradation affects|advcl|status status|nmod|END_ENTITY	Hepatitis_B_virus X protein differentially affects the ubiquitin-mediated proteasomal degradation of beta-catenin depending on the status of cellular p53 .
9738936	0	beta-catenin	40,52	presenilin-1	22,34	beta-catenin	presenilin-1	12387(Tax:10090)	19164(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of presenilin-1 with beta-catenin .
9790190	0	beta-catenin	19,31	presenilin-1	48,60	beta-catenin	presenilin-1	1499	5663	Gene	Gene	START_ENTITY|nmod|mutations mutations|nmod|potentiates potentiates|amod|END_ENTITY	Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis .
12874278	0	beta-catenin	51,63	tax-interacting_protein-1	16,41	beta-catenin	tax-interacting protein-1	1499	30851	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	The PDZ protein tax-interacting_protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal_cancer cells .
19335981	0	beta-catenin	11,23	transforming_growth_factor-beta1	79,111	beta-catenin	transforming growth factor-beta1	1499	7040	Gene	Gene	Effect|nmod|START_ENTITY induced|nsubj|Effect induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of beta-catenin on the activation of hepatic stellate cells induced by transforming_growth_factor-beta1 -RSB- .
18405667	0	beta-catenin	43,55	transglutaminase_2	14,32	beta-catenin	transglutaminase 2	1499	7052	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Extracellular transglutaminase_2 activates beta-catenin signaling in calcifying vascular smooth muscle cells .
15662032	0	beta-catenin	30,42	vascular_endothelial_growth_factor	92,126	beta-catenin	vascular endothelial growth factor	1499	7422	Gene	Gene	axis|amod|START_ENTITY promotes|nsubj|axis promotes|nmod|activation activation|nmod|END_ENTITY	Glycogen-Synthase_Kinase3beta / beta-catenin axis promotes angiogenesis through activation of vascular_endothelial_growth_factor signaling in endothelial cells .
19661296	0	beta-catenin_and_APC	26,46	E-cadherin	14,24	beta-catenin and APC	E-cadherin	1499;324	999	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Expression of E-cadherin , beta-catenin_and_APC protein in canine colorectal_tumours .
18702954	0	beta-chemokine	27,41	CCL2	42,46	beta-chemokine	CCL2	6352	6347	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis_C-associated cryoglobulinemia in the presence or absence of autoimmune_thyroiditis .
9344869	0	beta-chemokine	33,47	monocyte_chemotactic_protein-1	49,79	beta-chemokine	monocyte chemotactic protein-1	6352	6347	Gene	Gene	MCP-1|amod|START_ENTITY MCP-1|amod|END_ENTITY	The inhibition of synthesis of a beta-chemokine , monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- by progesterone .
17393183	0	beta-defensin-2	27,42	IL-4	51,55	beta-defensin-2	IL-4	100861169	100860814	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Downregulation of the goat beta-defensin-2 gene by IL-4 in caprine intestinal epithelial cells infected with Eimeria spp .
18556347	0	beta-defensin-2	22,37	Leptin	0,6	beta-defensin-2	Leptin	1673	3952	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Leptin enhances human beta-defensin-2 production in human keratinocytes .
22450687	0	beta-defensin-2	38,53	Tat	20,23	beta-defensin-2	Tat	1673	155871(Tax:11676)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP -1 dependent pathways in human B cells .
19735472	0	beta-defensin-2	43,58	Toll-like_receptor-4	0,20	beta-defensin-2	Toll-like receptor-4	1673	7099	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Toll-like_receptor-4 -LRB- TLR4 -RRB- mediates human beta-defensin-2 -LRB- HBD-2 -RRB- induction in response to Chlamydia_pneumoniae in mononuclear cells .
11841544	0	beta-defensin-2	6,21	interleukin-1	66,79	beta-defensin-2	interleukin-1	100289462	3552	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1 , bacteria , and the state of differentiation .
18567888	0	beta-defensin-2	14,29	tumor_necrosis_factor-alpha	37,64	beta-defensin-2	tumor necrosis factor-alpha	1673	7124	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of human beta-defensin-2 during tumor_necrosis_factor-alpha / NF-kappaB-mediated innate antiviral response against human_respiratory_syncytial_virus .
16984277	0	beta-defensin_1	14,29	DEFB1	36,41	beta-defensin 1	DEFB1	1672	1672	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SNPs in human beta-defensin_1 gene -LRB- DEFB1 -RRB- : frequencies in a Mexican population and new PCR-RFLPs assays .
18433872	0	beta-defensin_1	20,35	c-Myc	53,58	beta-defensin 1	c-Myc	1672	4609	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of human beta-defensin_1 is regulated via c-Myc and the biological clock .
19519528	0	beta-defensin_2	30,45	HBD2	47,51	beta-defensin 2	HBD2	1673	1673	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Efficient production of human beta-defensin_2 -LRB- HBD2 -RRB- in Escherichia_coli .
15013761	0	beta-defensin_2	23,38	MEF	0,3	beta-defensin 2	MEF	1673	2000	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	MEF up-regulates human beta-defensin_2 expression in epithelial cells .
17591792	0	beta-defensin_2	45,60	Protease-activated_receptor_2	0,29	beta-defensin 2	Protease-activated receptor 2	1673	2150	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Protease-activated_receptor_2 mediates human beta-defensin_2 and CC_chemokine_ligand_20 mRNA expression in response to proteases secreted by Porphyromonas_gingivalis .
11745329	0	beta-defensin_2	81,96	Toll-like_receptor_2	6,26	beta-defensin 2	Toll-like receptor 2	100289462	7097	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Human Toll-like_receptor_2 mediates induction of the antimicrobial peptide human beta-defensin_2 in response to bacterial lipoprotein .
12958190	0	beta-defensin_2	46,61	Toll-like_receptor_2	70,90	beta-defensin 2	Toll-like receptor 2	1673	7097	Gene	Gene	expression|nmod|START_ENTITY regulate|dobj|expression regulate|nmod|END_ENTITY	Airway epithelia regulate expression of human beta-defensin_2 through Toll-like_receptor_2 .
16219107	0	beta-defensin_2	81,96	Toll-like_receptor_4	37,57	beta-defensin 2	Toll-like receptor 4	1673	7099	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Respiratory epithelial cells require Toll-like_receptor_4 for induction of human beta-defensin_2 by lipopolysaccharide .
18492183	0	beta-defensin_2_or_3	72,92	hBD2	94,98	beta-defensin 2 or 3	hBD2	1673;55894	1673	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	An optimized method for intensive screening of molecules that stimulate beta-defensin_2_or_3 -LRB- hBD2 or hBD3 -RRB- expression in cultured normal human keratinocytes .
15627069	0	beta-defensin_3	6,21	hBD-3	23,28	beta-defensin 3	hBD-3	55894	55894	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Human beta-defensin_3 -LRB- hBD-3 -RRB- expression in A431 cell line and human vulval_tumors .
9395493	0	beta-dystrobrevin	0,17	dystrophin	39,49	beta-dystrobrevin	dystrophin	1838	1756	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	beta-dystrobrevin , a new member of the dystrophin family .
1978316	0	beta-endorphin	22,36	Fos	51,54	beta-endorphin	Fos	18976(Tax:10090)	14281(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Interleukin 1 induces beta-endorphin secretion via Fos and Jun in AtT-20 pituitary cells .
1592064	0	beta-endorphin	16,30	Met-enkephalin	0,14	beta-endorphin	Met-enkephalin	5443	5443	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	Met-enkephalin , beta-endorphin and cortisol responses to sub-maximal exercise after sleep_disturbances .
224076	0	beta-endorphin	133,147	beta-LPH	110,118	beta-endorphin	beta-LPH	5443	5443	Gene	Gene	conversion|nmod|START_ENTITY conversion|amod|END_ENTITY	ACTH , beta-LPH and beta-endorphin in pituitary_adenomas of the patients with Cushing 's _ disease : activation of beta-LPH conversion to beta-endorphin .
2528500	0	beta-endorphin	12,26	corticotropin-releasing_factor	49,79	beta-endorphin	corticotropin-releasing factor	5443	1392	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Increase of beta-endorphin serum levels by human corticotropin-releasing_factor does not affect beta-cell function in normal-weight men .
7675938	0	beta-endorphin	29,43	corticotropin-releasing_hormone	57,88	beta-endorphin	corticotropin-releasing hormone	5443	1392	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Cortisol , corticotropin , and beta-endorphin responses to corticotropin-releasing_hormone in patients with atopic_eczema .
10692113	0	beta-endorphin	0,14	cytokeratin_16	26,40	beta-endorphin	cytokeratin 16	5443	3868	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	beta-endorphin stimulates cytokeratin_16 expression and downregulates mu-opiate_receptor expression in human epidermis .
2977292	0	beta-endorphin	22,36	interferon-gamma	40,56	beta-endorphin	interferon-gamma	5443	3458	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Modulatory effects of beta-endorphin on interferon-gamma production by cultured peripheral blood mononuclear cells : heterogeneity among donors and the influence of culture medium .
16203256	0	beta-endorphin	62,76	interleukin-1alpha	42,60	beta-endorphin	interleukin-1alpha	5443	3552	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effect of maternal smoking on breast milk interleukin-1alpha , beta-endorphin , and leptin concentrations and leptin concentrations .
10825374	0	beta-endorphin	0,14	interleukin-8	42,55	beta-endorphin	interleukin-8	5443	3576	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	beta-endorphin inhibits the production of interleukin-8 by human chorio-decidual cells in culture .
17684846	0	beta-endorphin	23,37	met-enkephalin	7,21	beta-endorphin	met-enkephalin	5443	5443	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Plasma met-enkephalin , beta-endorphin and leu-enkephalin levels in human hepatic_encephalopathy .
8910459	0	beta-galactosidase	99,117	N-acetylgalactosamine-6-sulfate_sulfatase	15,56	beta-galactosidase	N-acetylgalactosamine-6-sulfate sulfatase	2720	2588	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of N-acetylgalactosamine-6-sulfate_sulfatase with the multienzyme lysosomal complex of beta-galactosidase , cathepsin_A , and neuraminidase .
12867545	0	beta-galactosidase	27,45	TB_G6	52,57	beta-galactosidase	TB G6	543610(Tax:4081)	543612(Tax:4081)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Antisense suppression of a beta-galactosidase gene -LRB- TB_G6 -RRB- in tomato increases fruit cracking .
9757570	1	beta-glucosidase_1	76,94	bgl1	96,100	beta-glucosidase 1	bgl1	851007(Tax:4932)	851007(Tax:4932)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	F-50 cellobiohydrolase I -LRB- cbhI -RRB- and beta-glucosidase_1 -LRB- bgl1 -RRB- genes by Saccharomyces_cerevisiae .
8565635	0	beta-glucuronidase	75,93	GUSB	100,104	beta-glucuronidase	GUSB	2990	2990	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization by fluorescence in situ hybridization of the human functional beta-glucuronidase gene -LRB- GUSB -RRB- to 7q11 .21 -- > q11 .22 and two pseudogenes to 5p13 and 5q13 .
2147427	0	beta-hexosaminidase	75,94	HEXB	30,34	beta-hexosaminidase	HEXB	10724	3074	Gene	Gene	beta-subunit|nmod|START_ENTITY encoding|dobj|beta-subunit initiation|acl|encoding initiation|nmod|gene gene|compound|END_ENTITY	Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase .
7918686	0	beta-hexosaminidase	31,50	HEXB	52,56	beta-hexosaminidase	HEXB	76055(Tax:10090)	15212(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the murine beta-hexosaminidase -LRB- HEXB -RRB- gene .
2449434	0	beta-hexosaminidase	28,47	alpha-chain	48,59	beta-hexosaminidase	alpha-chain	10724	2217	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Normal transcription of the beta-hexosaminidase alpha-chain gene in the Ashkenazi Tay-Sachs mutation .
2964446	0	beta-hexosaminidase	67,86	alpha-chain	30,41	beta-hexosaminidase	alpha-chain	10724	2217	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Proteolytic processing of the alpha-chain of the lysosomal enzyme , beta-hexosaminidase , in normal human fibroblasts .
6236461	0	beta-hexosaminidase	40,59	alpha-chain	75,86	beta-hexosaminidase	alpha-chain	10724	2217	Gene	Gene	alpha-chain|nmod|START_ENTITY clone|nmod|alpha-chain clone|dep|deficiency deficiency|nmod|mRNA mRNA|amod|END_ENTITY	cDNA clone for the alpha-chain of human beta-hexosaminidase : deficiency of alpha-chain mRNA in Ashkenazi Tay-Sachs fibroblasts .
9245689	0	beta-ketothiolase	64,81	SCPx	154,158	beta-ketothiolase	SCPx	30	6342	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Sterol_carrier_protein_X -LRB- SCPx -RRB- is a peroxisomal branched-chain beta-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA : a new , unique role for SCPx in branched-chain fatty_acid metabolism in peroxisomes .
10223937	0	beta-lactamase	83,97	outer_membrane_protein	124,146	beta-lactamase	outer membrane protein	7872529(Tax:562)	18157965	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Carbapenem resistance in Escherichia_coli associated with plasmid-determined CMY-4 beta-lactamase production and loss of an outer_membrane_protein .
6315546	0	beta-lipotropin	12,27	ACTH	6,10	beta-lipotropin	ACTH	5443	5443	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Human ACTH , beta-lipotropin and beta-endorphin levels in maternal plasma at delivery .
6309526	0	beta-lipotropin	16,31	Beta-endorphin	0,14	beta-lipotropin	Beta-endorphin	5443	5443	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Beta-endorphin , beta-lipotropin and adrenocorticotropic hormone levels in cerebrospinal fluid , and brain_damage in chronic alcoholics .
18974267	0	beta-melanocyte-stimulating_hormone	86,121	melanocortin-4_receptor	122,145	beta-melanocyte-stimulating hormone	melanocortin-4 receptor	5443	4160	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating_hormone / melanocortin-4_receptor signaling .
590341	0	beta-melanocyte_stimulating_hormone	13,48	beta-MSH	50,58	beta-melanocyte stimulating hormone	beta-MSH	5443	5443	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	An effect of beta-melanocyte_stimulating_hormone -LRB- beta-MSH -RRB- on alpha-motoneurones of cat spinal cord .
9016779	0	beta-myosin_heavy_chain	14,37	betaMHC	39,46	beta-myosin heavy chain	betaMHC	29557(Tax:10116)	29557(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Divergence of beta-myosin_heavy_chain -LRB- betaMHC -RRB- expression in fetal rat cardiomyocytes in vitro and adult rat heart in vivo .
11211053	0	beta-secretase	26,40	BACE	42,46	beta-secretase	BACE	23621	23621	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Amyloid precursor protein beta-secretase -LRB- BACE -RRB- mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors .
15466887	0	beta-secretase	23,37	BACE	17,21	beta-secretase	BACE	23621	23621	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|amod|END_ENTITY	Demonstration of BACE -LRB- beta-secretase -RRB- phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy .
16293430	0	beta-secretase	37,51	BACE	53,57	beta-secretase	BACE	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Linear interaction energy models for beta-secretase -LRB- BACE -RRB- inhibitors : Role of van der Waals , electrostatic , and continuum-solvation terms .
12356481	0	beta-secretase	61,75	BACE-1	77,83	beta-secretase	BACE-1	23621	23621	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Recombinant insect cell expression and purification of human beta-secretase -LRB- BACE-1 -RRB- for X-ray crystallography .
17541560	0	beta-secretase	74,88	BACE-1	90,96	beta-secretase	BACE-1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Multiwell fluorometric and colorimetric microassays for the evaluation of beta-secretase -LRB- BACE-1 -RRB- inhibitors .
15916426	0	beta-secretase	22,36	BACE1	38,43	beta-secretase	BACE1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Virtual screening for beta-secretase -LRB- BACE1 -RRB- inhibitors reveals the importance of protonation states at Asp32 and Asp228 .
17429617	0	beta-secretase	66,80	BACE1	82,87	beta-secretase	BACE1	29392(Tax:10116)	29392(Tax:10116)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase -LRB- BACE1 -RRB- proteins and activity in vivo in the rat retina .
19959359	0	beta-secretase	83,97	BACE1	99,104	beta-secretase	BACE1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery and initial optimization of 5,5 ' - disubstituted_aminohydantoins as potent beta-secretase -LRB- BACE1 -RRB- inhibitors .
19968289	0	beta-secretase	89,103	BACE1	105,110	beta-secretase	BACE1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design and synthesis of 5,5 ' - disubstituted_aminohydantoins as potent and selective human beta-secretase -LRB- BACE1 -RRB- inhibitors .
20223661	0	beta-secretase	62,76	BACE1	78,83	beta-secretase	BACE1	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel pyrrolyl_2-aminopyridines as potent and selective human beta-secretase -LRB- BACE1 -RRB- inhibitors .
18393797	0	beta-secretase	12,26	Memapsin_2	0,10	beta-secretase	Memapsin 2	23621	23621	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Memapsin_2 -LRB- beta-secretase -RRB- inhibitors : drug development .
17470798	0	beta-site_APP_cleaving_enzyme_1	15,46	BACE1	48,53	beta-site APP cleaving enzyme 1	BACE1	23821(Tax:10090)	23821(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of beta-site_APP_cleaving_enzyme_1 -LRB- BACE1 -RRB- in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity .
25411915	0	beta-site_amyloid_precursor_protein_cleaving_enzyme_1	50,103	BACE1	105,110	beta-site amyloid precursor protein cleaving enzyme 1	BACE1	29392(Tax:10116)	29392(Tax:10116)	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	8-Tetrahydropyran-2-yl_chromans : highly selective beta-site_amyloid_precursor_protein_cleaving_enzyme_1 -LRB- BACE1 -RRB- inhibitors .
2968397	0	beta-thromboglobulin	7,27	platelet_factor_4	31,48	beta-thromboglobulin	platelet factor 4	5473	5196	Gene	Gene	START_ENTITY|nmod|ratios ratios|amod|END_ENTITY	Plasma beta-thromboglobulin to platelet_factor_4 ratios as indices of vascular_complications in essential hypertension .
18354028	0	beta1	26,31	Fyn	76,79	beta1	Fyn	15129(Tax:10090)	14360(Tax:10090)	Gene	Gene	outgrowth|nummod|START_ENTITY requires|nsubj|outgrowth requires|xcomp|kinase kinase|nsubj|END_ENTITY	Voltage-gated Na + channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo .
9616217	0	beta1	106,111	alpha4	99,105	beta1	alpha4	3779	3476	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and function .
9867821	0	beta1	38,43	alpha4	31,37	beta1	alpha4	3779	3476	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Cooperative role for activated alpha4 beta1 integrin and chondroitin sulfate proteoglycans in cell adhesion to the heparin III domain of fibronectin .
10376806	0	beta1	100,105	beta2	113,118	beta1	beta2	3779	10242	Gene	Gene	START_ENTITY|nmod|subtype subtype|amod|END_ENTITY	Coupling of beta-adrenergic receptors to cardiac L-type Ca2 + channels : preferential coupling of the beta1 versus beta2 receptor subtype and evidence for PKA-independent activation of the channel .
10685868	0	beta1	116,121	beta2	193,198	beta1	beta2	15129(Tax:10090)	15130(Tax:10090)	Gene	Gene	atria|amod|START_ENTITY atria|dep|evidence evidence|nmod|function function|amod|END_ENTITY	Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through beta1 - and putative beta4-adrenoceptors in mouse left atria : no evidence for beta2 - and beta3-adrenoreceptor function .
11026647	0	beta1	51,56	beta2	59,64	beta1	beta2	10678	10242	Gene	Gene	Binding|dep|START_ENTITY Binding|dep|END_ENTITY	Binding properties of beta-blockers at recombinant beta1 - , beta2 - , and beta3-adrenoceptors .
18797996	0	beta1	21,26	beta2	28,33	beta1	beta2	10678	10242	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Monitoring the human beta1 , beta2 , beta3 adrenergic receptors expression and purification in Pichia_pastoris using the fluorescence properties of the enhanced green fluorescent protein .
12671732	0	beta1	66,71	interleukin-23_receptor	41,64	beta1	interleukin-23 receptor	3779	149233	Gene	Gene	chain|appos|START_ENTITY chain|amod|END_ENTITY	Genetic variations in the interleukin-12 / interleukin-23_receptor -LRB- beta1 -RRB- chain , and implications for IL-12 and IL-23_receptor structure and function .
18826941	0	beta1,3-N-acetylglucosaminyltransferase-2	14,55	beta3Gn-T2	57,67	beta1,3-N-acetylglucosaminyltransferase-2	beta3Gn-T2	10678	10678	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of beta1,3-N-acetylglucosaminyltransferase-2 -LRB- beta3Gn-T2 -RRB- by beta3Gn-T8 .
18826941	0	beta1,3-N-acetylglucosaminyltransferase-2	14,55	beta3Gn-T8	72,82	beta1,3-N-acetylglucosaminyltransferase-2	beta3Gn-T8	10678	374907	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of beta1,3-N-acetylglucosaminyltransferase-2 -LRB- beta3Gn-T2 -RRB- by beta3Gn-T8 .
11501844	0	beta1-integrin	20,34	CD29	37,41	beta1-integrin	CD29	3688	3688	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of beta1-integrin -LRB- = CD29 -RRB- in serous adenocarcinomas of the ovary .
14522909	0	beta1-integrin	110,124	Insulin-like_growth_factor-1	0,28	beta1-integrin	Insulin-like growth factor-1	3688	3479	Gene	Gene	activation|nmod|START_ENTITY cells|nmod|activation induces|nmod|cells induces|nsubj|END_ENTITY	Insulin-like_growth_factor-1 induces adhesion and migration in human multiple_myeloma cells via activation of beta1-integrin and phosphatidylinositol_3 ' - kinase/AKT signaling .
16320828	0	beta1-integrin	95,109	caspase-3	139,148	beta1-integrin	caspase-3	3688	836	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3 : an immunomorphological study .
15539082	0	beta1-integrins	116,131	CD34	141,145	beta1-integrins	CD34	3688	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Phosphatidylinositol-3-kinase activation mediates proline-rich_tyrosine_kinase_2 phosphorylation and recruitment to beta1-integrins in human CD34 + cells .
15539082	0	beta1-integrins	116,131	proline-rich_tyrosine_kinase_2	50,80	beta1-integrins	proline-rich tyrosine kinase 2	3688	2185	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Phosphatidylinositol-3-kinase activation mediates proline-rich_tyrosine_kinase_2 phosphorylation and recruitment to beta1-integrins in human CD34 + cells .
301546	0	beta1H	130,136	C3b	153,156	beta1H	C3b	3075	718	Gene	Gene	START_ENTITY|nmod|cleavage cleavage|nmod|END_ENTITY	Human complement C3b_inactivator : isolation , characterization , and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution .
15339048	0	beta1_integrin	95,109	CEACAM1	28,35	beta1 integrin	CEACAM1	3688	634	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1_integrin in a 3D model of morphogenesis .
15023537	0	beta1_integrin	76,90	Cadherin-related_neuronal_receptor_1	0,36	beta1 integrin	Cadherin-related neuronal receptor 1	3688	56117	Gene	Gene	activity|nmod|START_ENTITY has|dobj|activity has|nsubj|END_ENTITY	Cadherin-related_neuronal_receptor_1 -LRB- CNR1 -RRB- has cell adhesion activity with beta1_integrin mediated through the RGD site of CNR1 .
17658473	0	beta1_integrin	43,57	Gab1	19,23	beta1 integrin	Gab1	3688	2549	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	The involvement of Gab1 and PI 3-kinase in beta1_integrin signaling in keratinocytes .
19723874	0	beta1_integrin	101,115	HOXA4	46,51	beta1 integrin	HOXA4	3688	3201	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Cell motility and spreading are suppressed by HOXA4 in ovarian_cancer cells : possible involvement of beta1_integrin .
15375568	0	beta1_integrin	14,28	PKCepsilon	43,53	beta1 integrin	PKCepsilon	3688	5581	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of beta1_integrin expression by PKCepsilon in renal_cancer cells .
15385257	0	beta1_integrin	102,116	TNF-alpha	143,152	beta1 integrin	TNF-alpha	3688	7124	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Cardiac surgery with extracorporeal circulation : neutrophil transendothelial migration is mediated by beta1_integrin -LRB- CD29 -RRB- in the presence of TNF-alpha .
12900408	0	beta2	32,37	AP-2	74,78	beta2	AP-2	10242	7020	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Tyrosine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 reveals the role of a di-leucine motif in the epidermal_growth_factor_receptor trafficking .
11265644	0	beta2	56,61	Beta1	0,5	beta2	Beta1	10242	3779	Gene	Gene	adhesion|amod|START_ENTITY promotes|dobj|adhesion promotes|nsubj|activation activation|amod|END_ENTITY	Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin .
10845922	0	beta2	30,35	CD11c	24,29	beta2	CD11c	10242	3687	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Engagement of CD11b and CD11c beta2 integrin by antibodies or soluble CD23 induces IL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways .
17937931	0	beta2	66,71	Cyclin_G_associated_kinase	0,26	beta2	Cyclin G associated kinase	10242	2580	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cyclin_G_associated_kinase interacts with interleukin 12 receptor beta2 and suppresses interleukin 12 induced IFN-gamma production .
10376806	0	beta2	113,118	beta1	100,105	beta2	beta1	10242	3779	Gene	Gene	subtype|amod|START_ENTITY END_ENTITY|nmod|subtype	Coupling of beta-adrenergic receptors to cardiac L-type Ca2 + channels : preferential coupling of the beta1 versus beta2 receptor subtype and evidence for PKA-independent activation of the channel .
10685868	0	beta2	193,198	beta1	116,121	beta2	beta1	15130(Tax:10090)	15129(Tax:10090)	Gene	Gene	function|amod|START_ENTITY evidence|nmod|function atria|dep|evidence atria|amod|END_ENTITY	Pertussis toxin suppresses carbachol-evoked cardiodepression but does not modify cardiostimulation mediated through beta1 - and putative beta4-adrenoceptors in mouse left atria : no evidence for beta2 - and beta3-adrenoreceptor function .
11026647	0	beta2	59,64	beta1	51,56	beta2	beta1	10242	10678	Gene	Gene	Binding|dep|START_ENTITY Binding|dep|END_ENTITY	Binding properties of beta-blockers at recombinant beta1 - , beta2 - , and beta3-adrenoceptors .
18797996	0	beta2	28,33	beta1	21,26	beta2	beta1	10242	10678	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Monitoring the human beta1 , beta2 , beta3 adrenergic receptors expression and purification in Pichia_pastoris using the fluorescence properties of the enhanced green fluorescent protein .
11107052	0	beta2	78,83	beta3	85,90	beta2	beta3	10242	1934	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of cytokeratin_1 , _ 5 , _ 14 , _ 19_and_transforming_growth_factors-beta1 , beta2 , beta3 in osteofibrous_dysplasia and adamantinoma : A possible association of transforming_growth_factor-beta with basal cell phenotype promotion .
15178407	0	beta2-AR	66,74	interleukin-18	36,50	beta2-AR	interleukin-18	154	3606	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR , PI3K , Akt , IKK , and NF-kappaB .
10441168	0	beta2-GPI	41,50	beta2-glycoprotein_I	19,39	beta2-GPI	beta2-glycoprotein I	350	350	Gene	Gene	involvement|dep|START_ENTITY involvement|nmod|END_ENTITY	The involvement of beta2-glycoprotein_I -LRB- beta2-GPI -RRB- in human and murine atherosclerosis .
16723738	0	beta2-adaptin	102,115	AP-2	131,135	beta2-adaptin	AP-2	163	21418(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|complex complex|compound|END_ENTITY	Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex .
16030021	0	beta2-adrenergic_receptor	180,205	ERK	223,226	beta2-adrenergic receptor	ERK	154	5594	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic_receptor to activation of ERK in HEK293B2 cells .
11238007	0	beta2-adrenergic_receptor	18,43	IL-1beta	0,8	beta2-adrenergic receptor	IL-1beta	154	3553	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-1beta enhances beta2-adrenergic_receptor expression in human airway epithelial cells by activating PKC .
9873044	0	beta2-adrenergic_receptor	64,89	glucocorticoid_receptor	37,60	beta2-adrenergic receptor	glucocorticoid receptor	154	2908	Gene	Gene	agonists|amod|START_ENTITY END_ENTITY|nmod|agonists	Ligand-independent activation of the glucocorticoid_receptor by beta2-adrenergic_receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells .
10738947	0	beta2-adrenoceptor	52,70	S1319	15,20	beta2-adrenoceptor	S1319	154	1077695(Tax:198215)	Gene	Gene	agonist|amod|START_ENTITY END_ENTITY|appos|agonist	The effects of S1319 , a novel marine sponge-derived beta2-adrenoceptor agonist , on IgE-mediated activation of human cultured mast cells .
12608646	0	beta2-adrenoceptor	46,64	tumor_necrosis_factor-alpha	15,42	beta2-adrenoceptor	tumor necrosis factor-alpha	24176(Tax:10116)	24835(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Suppression of tumor_necrosis_factor-alpha by beta2-adrenoceptor activation : role of mitogen-activated protein kinases in renal mesangial cells .
10441168	0	beta2-glycoprotein_I	19,39	beta2-GPI	41,50	beta2-glycoprotein I	beta2-GPI	350	350	Gene	Gene	involvement|nmod|START_ENTITY involvement|dep|END_ENTITY	The involvement of beta2-glycoprotein_I -LRB- beta2-GPI -RRB- in human and murine atherosclerosis .
9649198	0	beta2-glycoprotein_I	55,75	protein_C	41,50	beta2-glycoprotein I	protein C	350	5624	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of anticardiolipin antibodies to protein_C via beta2-glycoprotein_I -LRB- beta2-GPI -RRB- : a possible mechanism in the inhibitory effect of antiphospholipid antibodies on the protein_C system .
15750984	0	beta2-microglobulin	13,32	Cystatin_C	1,11	beta2-microglobulin	Cystatin C	567	1471	Gene	Gene	hemodialysis|amod|START_ENTITY END_ENTITY|appos|hemodialysis	-LSB- Cystatin_C , beta2-microglobulin and C-reactive_protein in hemodiafiltration and on-line endogenous liquid reinfusion and in low flux polysulphone_bicarbonate conventional hemodialysis -RSB- .
11685454	0	beta2-microglobulin	134,153	HLA-B27	126,133	beta2-microglobulin	HLA-B27	567	3106	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27 / beta2-microglobulin complex .
10792621	0	beta2-microglobulin	0,19	MMP-1	28,33	beta2-microglobulin	MMP-1	567	4312	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	beta2-microglobulin induces MMP-1 but not TIMP-1 expression in human synovial fibroblasts .
18164932	0	beta2-microglobulin	60,79	Procollagen_C-proteinase_enhancer-1	0,35	beta2-microglobulin	Procollagen C-proteinase enhancer-1	567	5118	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Procollagen_C-proteinase_enhancer-1 -LRB- PCPE-1 -RRB- interacts with beta2-microglobulin -LRB- beta2-m -RRB- and may help initiate beta2-m amyloid fibril formation in connective tissues .
19232662	0	beta2-microglobulin	29,48	TNF	76,79	beta2-microglobulin	TNF	567	7124	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Interaction of human TNF and beta2-microglobulin with Tanapox_virus-encoded TNF inhibitor , TPV-2L .
78517	0	beta2-microglobulin	29,48	albumin	21,28	beta2-microglobulin	albumin	567	213	Gene	Gene	chains|amod|START_ENTITY chains|compound|END_ENTITY	Urinary excretion of albumin beta2-microglobulin and free light chains during lithium treatment .
8981920	0	beta2-microglobulin	81,100	beta2m	102,108	beta2-microglobulin	beta2m	567	567	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|appos|END_ENTITY	HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin -LRB- beta2m -RRB- double transgenic_mice with disrupted mouse beta2m .
10987196	0	beta2-microglobulin	58,77	cathepsin_D	24,35	beta2-microglobulin	cathepsin D	567	1509	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	Probable involvement of cathepsin_D in the degradation of beta2-microglobulin in acidic urine .
19761720	0	beta2-microglobulin	83,102	interferon-gamma	33,49	beta2-microglobulin	interferon-gamma	567	3458	Gene	Gene	role|nmod|START_ENTITY production|dep|role production|amod|END_ENTITY	Low-flux hemodialysis suppresses interferon-gamma production : the possible role of beta2-microglobulin .
10636491	0	beta2-microglobulin	20,39	monocyte_chemotactic_protein-1	41,71	beta2-microglobulin	monocyte chemotactic protein-1	567	6347	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Cerebrospinal fluid beta2-microglobulin , monocyte_chemotactic_protein-1 , and soluble tumour necrosis factor alpha receptors before and after treatment with lamivudine plus zidovudine or stavudine .
16081942	0	beta2-toxin	28,39	cpb2	46,50	beta2-toxin	cpb2	13918017	13918017	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulated expression of the beta2-toxin gene -LRB- cpb2 -RRB- in Clostridium_perfringens type a isolates from horses with gastrointestinal_diseases .
15833737	0	beta2_adrenoreceptor	43,63	Interleukin-1beta	0,17	beta2 adrenoreceptor	Interleukin-1beta	154	3553	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Interleukin-1beta differentially regulates beta2_adrenoreceptor and prostaglandin_E2-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells .
8981920	0	beta2m	102,108	beta2-microglobulin	81,100	beta2m	beta2-microglobulin	567	567	Gene	Gene	transgenic_mice|appos|START_ENTITY transgenic_mice|amod|END_ENTITY	HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human beta2-microglobulin -LRB- beta2m -RRB- double transgenic_mice with disrupted mouse beta2m .
16513293	0	beta3	31,36	NFATc1	0,6	beta3	NFATc1	1934	4772	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|amod|END_ENTITY	NFATc1 regulation of the human beta3 integrin promoter in osteoclast differentiation .
11107052	0	beta3	85,90	beta2	78,83	beta3	beta2	1934	10242	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of cytokeratin_1 , _ 5 , _ 14 , _ 19_and_transforming_growth_factors-beta1 , beta2 , beta3 in osteofibrous_dysplasia and adamantinoma : A possible association of transforming_growth_factor-beta with basal cell phenotype promotion .
9622194	0	beta3-adrenoceptor	21,39	Nerve_growth_factor	0,19	beta3-adrenoceptor	Nerve growth factor	25645(Tax:10116)	310738(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Nerve_growth_factor , beta3-adrenoceptor and uncoupling protein 1 expression in rat brown fat during postnatal development .
9931340	0	beta3A	4,10	Ap3b1	25,30	beta3A	Ap3b1	11774(Tax:10090)	11774(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The beta3A subunit gene -LRB- Ap3b1 -RRB- of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl , a model for Hermansky-Pudlak_syndrome and night_blindness .
18826941	0	beta3Gn-T2	57,67	beta1,3-N-acetylglucosaminyltransferase-2	14,55	beta3Gn-T2	beta1,3-N-acetylglucosaminyltransferase-2	10678	10678	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of beta1,3-N-acetylglucosaminyltransferase-2 -LRB- beta3Gn-T2 -RRB- by beta3Gn-T8 .
18826941	0	beta3Gn-T2	57,67	beta3Gn-T8	72,82	beta3Gn-T2	beta3Gn-T8	10678	374907	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of beta1,3-N-acetylglucosaminyltransferase-2 -LRB- beta3Gn-T2 -RRB- by beta3Gn-T8 .
18826941	0	beta3Gn-T8	72,82	beta1,3-N-acetylglucosaminyltransferase-2	14,55	beta3Gn-T8	beta1,3-N-acetylglucosaminyltransferase-2	374907	10678	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of beta1,3-N-acetylglucosaminyltransferase-2 -LRB- beta3Gn-T2 -RRB- by beta3Gn-T8 .
18826941	0	beta3Gn-T8	72,82	beta3Gn-T2	57,67	beta3Gn-T8	beta3Gn-T2	374907	10678	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of beta1,3-N-acetylglucosaminyltransferase-2 -LRB- beta3Gn-T2 -RRB- by beta3Gn-T8 .
10588882	0	beta3_tubulin	42,55	betaTub60D	62,72	beta3 tubulin	betaTub60D	37888(Tax:7227)	37888(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tinman regulates the transcription of the beta3_tubulin gene -LRB- betaTub60D -RRB- in the dorsal vessel of Drosophila .
12951058	0	beta4	74,79	ADD2	69,73	beta4	ADD2	10381	119	Gene	Gene	variants|amod|START_ENTITY variants|nummod|END_ENTITY	Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants .
14579272	0	beta4	61,66	IL-6	100,104	beta4	IL-6	10381	3569	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	p38 MAPK is a critical regulator of the constitutive and the beta4 integrin-regulated expression of IL-6 in human normal thymic epithelial cells .
26531472	0	beta4GalT-VII	20,33	Wee1	0,4	beta4GalT-VII	Wee1	11285	7465	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Wee1 interacts with beta4GalT-VII in neuronal development .
16914549	0	beta5	10,15	Annexin_V	0,9	beta5	Annexin V	10382	308	Gene	Gene	interactions|amod|START_ENTITY regulate|nsubj|interactions END_ENTITY|parataxis|regulate	Annexin_V / beta5 integrin interactions regulate apoptosis of growth plate chondrocytes .
10614649	0	beta5	46,51	Tumor_necrosis_factor_alpha	0,27	beta5	Tumor necrosis factor alpha	16419(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha regulates alpha -LRB- v -RRB- beta5 integrin expression by osteoclast precursors in vitro and in vivo .
16762799	0	betaARK1	27,35	GRK2	21,25	betaARK1	GRK2	156	156	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Lymphocyte levels of GRK2 -LRB- betaARK1 -RRB- mirror changes in the LVAD-supported failing human heart : lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading .
10571539	0	betaARK1	113,121	beta-adrenergic_receptor_kinase-1	78,111	betaARK1	beta-adrenergic receptor kinase-1	110355(Tax:10090)	110355(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Overexpression of the cardiac beta -LRB- 2 -RRB- - adrenergic_receptor and expression of a beta-adrenergic_receptor_kinase-1 -LRB- betaARK1 -RRB- inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic_injury .
9537418	0	betaII-spectrin	65,80	schwannomin	38,49	betaII-spectrin	schwannomin	6711	4771	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin .
15060062	0	betaIL-3	36,44	Interleukin-3	0,13	betaIL-3	Interleukin-3	12984(Tax:10090)	16187(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Interleukin-3 binding to the murine betaIL-3 and human betac receptors involves functional epitopes formed by domains 1 and 4 of different protein chains .
20657013	0	betaKlotho	20,30	fibroblast_growth_factor_receptor_4	46,81	betaKlotho	fibroblast growth factor receptor 4	152831	2264	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Metabolic regulator betaKlotho interacts with fibroblast_growth_factor_receptor_4 -LRB- FGFR4 -RRB- to induce apoptosis and inhibit tumor cell proliferation .
9016779	0	betaMHC	39,46	beta-myosin_heavy_chain	14,37	betaMHC	beta-myosin heavy chain	29557(Tax:10116)	29557(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Divergence of beta-myosin_heavy_chain -LRB- betaMHC -RRB- expression in fetal rat cardiomyocytes in vitro and adult rat heart in vivo .
19861492	0	betaPIX	88,95	Rac1	56,60	betaPIX	Rac1	54126(Tax:10090)	19353(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Stat3 promotes directional cell migration by regulating Rac1 activity via its activator betaPIX .
16329988	0	betaPix	46,53	NADPH_oxidase_1	25,40	betaPix	NADPH oxidase 1	8874	27035	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Molecular interaction of NADPH_oxidase_1 with betaPix and Nox_Organizer_1 .
18385518	0	betaPix	21,28	betaPix	48,55	betaPix	betaPix	8874	8874	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Endothelin-1 couples betaPix to p66Shc : role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt .
18385518	0	betaPix	48,55	betaPix	21,28	betaPix	betaPix	8874	8874	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Endothelin-1 couples betaPix to p66Shc : role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt .
11238952	0	betaTrCP	80,88	SCF	76,79	betaTrCP	SCF	8945	4254	Gene	Gene	ligase|appos|START_ENTITY ligase|amod|END_ENTITY	ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF -LRB- betaTrCP -RRB- ubiquitin ligase .
14561767	0	betaTrCP	64,72	Vpu	6,9	betaTrCP	Vpu	8945	155945(Tax:11676)	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	HIV-1 Vpu sequesters beta-transducin_repeat-containing_protein -LRB- betaTrCP -RRB- in the cytoplasm and provokes the accumulation of beta-catenin and other SCFbetaTrCP substrates .
10644755	0	betaTrCP1	32,41	Homodimer	0,9	betaTrCP1	Homodimer	8945	6647	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|nmod|proteins	Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination .
10588882	0	betaTub60D	62,72	beta3_tubulin	42,55	betaTub60D	beta3 tubulin	37888(Tax:7227)	37888(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Tinman regulates the transcription of the beta3_tubulin gene -LRB- betaTub60D -RRB- in the dorsal vessel of Drosophila .
7738011	0	beta_1	51,57	Ucp	43,46	beta 1	Ucp	15129(Tax:10090)	22227(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the uncoupling protein gene -LRB- Ucp -RRB- by beta_1 , beta_2 , and beta_3-adrenergic_receptor subtypes in immortalized brown adipose cell lines .
6450208	0	beta_1	80,86	alpha_1	52,59	beta 1	alpha 1	10678	146	Gene	Gene	goes|nmod|START_ENTITY goes|nsubj|END_ENTITY	Purification and characterization of a rabbit liver alpha_1 goes to 3 mannoside beta_1 goes to 2 N-acetylglucosaminyltransferase .
9816692	0	beta_1	24,30	alpha_1	40,47	beta 1	alpha 1	3779	146	Gene	Gene	START_ENTITY|appos|bloker bloker|amod|END_ENTITY	-LSB- Effects of carvedilol -LRB- beta_1 , beta_2 , alpha_1 bloker -RRB- on refractory congestive heart_failure -RSB- .
7517944	0	beta_1	26,32	alpha_4	18,25	beta 1	alpha 4	3779	3476	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Activation of the alpha_4 beta_1 integrin through the beta_1 subunit induces recognition of the RGDS sequence in fibronectin .
6130932	0	beta_1	17,23	beta_2	35,41	beta 1	beta 2	3779	10242	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|blockade blockade|amod|END_ENTITY	-LSB- Effect of acute beta_1 and beta_1 / beta_2 receptor blockade on carbohydrate and lipid metabolism during exertion -RSB- .
7649300	0	beta_1	52,58	beta_2	97,103	beta 1	beta 2	3779	10242	Gene	Gene	gene|amod|START_ENTITY gene|nmod|product product|amod|END_ENTITY	Alternative splicing of the human Shaker K + channel beta_1 gene and functional expression of the beta_2 gene product .
8099116	0	beta_1	97,103	beta_2	34,40	beta 1	beta 2	10678	10242	Gene	Gene	heterodimer|amod|START_ENTITY expression|nmod|heterodimer Evidence|dep|expression Evidence|nmod|integrins integrins|nmod|END_ENTITY	Evidence for integrins other than beta_2 on polymorphonuclear neutrophils : expression of alpha 6 beta_1 heterodimer .
8120022	0	beta_1	48,54	beta_2	57,63	beta 1	beta 2	10678	10242	Gene	Gene	n-butyric_acid|nmod|START_ENTITY modulation|nmod|n-butyric_acid modulation|dep|END_ENTITY	Transcriptional modulation by n-butyric_acid of beta_1 - , beta_2 - , and beta 3-adrenergic receptor balance in 3T3-F442A adipocytes .
8799564	0	beta_1	35,41	beta_2	44,50	beta 1	beta 2	10678	10242	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Respective degree of expression of beta_1 - , beta_2 - and beta_3-adrenoceptors in human brown and white adipose tissues .
9113375	0	beta_1	38,44	beta_2	47,53	beta 1	beta 2	10678	10242	Gene	Gene	evidence|nmod|START_ENTITY evidence|amod|END_ENTITY	Functional and molecular evidence for beta_1 - , beta_2 - and beta_3 - adrenoceptors in human colon .
9816692	0	beta_1	24,30	beta_2	32,38	beta 1	beta 2	3779	10242	Gene	Gene	START_ENTITY|appos|bloker bloker|amod|END_ENTITY	-LSB- Effects of carvedilol -LRB- beta_1 , beta_2 , alpha_1 bloker -RRB- on refractory congestive heart_failure -RSB- .
11244970	0	beta_1	33,39	integrin_alpha_5	15,31	beta 1	integrin alpha 5	3779	3678	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	-LSB- Expression of integrin_alpha_5 , beta_1 subunit and fibronectin mRNAs in human hepatocellular_carcinoma -RSB- .
1690718	0	beta_1	13,19	vitronectin	101,112	beta 1	vitronectin	3779	7448	Gene	Gene	associates|amod|START_ENTITY v|nsubj|associates v|xcomp|subunit subunit|xcomp|form form|dobj|receptor receptor|compound|END_ENTITY	The integrin beta_1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line .
1690718	0	beta_1	13,19	vitronectin	48,59	beta 1	vitronectin	3779	7448	Gene	Gene	associates|amod|START_ENTITY associates|nmod|alpha alpha|compound|END_ENTITY	The integrin beta_1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line .
7542669	0	beta_1	8,14	vitronectin	33,44	beta 1	vitronectin	10678	7448	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Alpha v beta_1 is a receptor for vitronectin and fibrinogen , and acts with alpha 5 beta_1 to mediate spreading on fibronectin .
7679169	0	beta_1-adrenoceptor	73,92	T-0509	53,59	beta 1-adrenoceptor	T-0509	153	1069472(Tax:209261)	Gene	Gene	agonist|amod|START_ENTITY END_ENTITY|appos|agonist	ICI_147 ,798 causes insurmountable antagonism against T-0509 , a selective beta_1-adrenoceptor agonist , but surmountable antagonism against isoproterenol .
3023226	0	beta_1-adrenoceptor	88,107	renin	7,12	beta 1-adrenoceptor	renin	153	5972	Gene	Gene	blockade|amod|START_ENTITY END_ENTITY|nmod|blockade	Plasma renin activity , active and inactive renin concentrations , and their responses to beta_1-adrenoceptor blockade with metoprolol in hyperthyroidism .
16547500	0	beta_1-integrin	59,74	Cholecystokinin-2_receptor	0,26	beta 1-integrin	Cholecystokinin-2 receptor	3688	887	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Cholecystokinin-2_receptor modulates cell adhesion through beta_1-integrin in human pancreatic_cancer cells .
10804218	0	beta_1_integrin	15,30	focal_adhesion_kinase	36,57	beta 1 integrin	focal adhesion kinase	3688	5747	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of beta_1_integrin with focal_adhesion_kinase and paxillin in differentiating Schwann cells .
8557753	0	beta_1_integrin	62,77	phosphatidylinositol_3-kinase	11,40	beta 1 integrin	phosphatidylinositol 3-kinase	3688	5293	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity END_ENTITY|nmod|regulation	A role for phosphatidylinositol_3-kinase in the regulation of beta_1_integrin activity by the CD2 antigen .
15485886	0	beta_1_integrins	33,49	SLC3A2	8,14	beta 1 integrins	SLC3A2	3688	6520	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	CD98hc -LRB- SLC3A2 -RRB- interaction with beta_1_integrins is required for transformation .
7851879	0	beta_2	15,21	GABRB2	36,42	beta 2	GABRB2	10242	2561	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the beta_2 subunit gene -LRB- GABRB2 -RRB- to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform .
8566068	0	beta_2	4,10	Mac-1	20,25	beta 2	Mac-1	10242	3689	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	The beta_2 integrin Mac-1 but not p150 ,95 associates with Fc_gamma_RIIA .
11342655	0	beta_2	22,28	RhoA	52,56	beta 2	RhoA	10242	387	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Role of p190RhoGAP in beta_2 integrin regulation of RhoA in human neutrophils .
10491012	0	beta_2	141,147	STAT4	182,187	beta 2	STAT4	10383	6775	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Depressed IL-12-mediated signal transduction in T cells from patients with S __ zary_syndrome is associated with the absence of IL-12 receptor beta_2 mRNA and highly reduced levels of STAT4 .
8799564	0	beta_2	44,50	beta_1	35,41	beta 2	beta 1	10242	10678	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Respective degree of expression of beta_1 - , beta_2 - and beta_3-adrenoceptors in human brown and white adipose tissues .
7840504	0	beta_2	50,56	beta_3	58,64	beta 2	beta 3	10242	1934	Gene	Gene	Expression|amod|START_ENTITY Expression|appos|END_ENTITY	Expression of transforming growth factors beta_1 , beta_2 , beta_3 in neuroendocrine_tumors of the digestive system .
7525604	0	beta_2	52,58	paxillin	116,124	beta 2	paxillin	10242	5829	Gene	Gene	Mac-1|dep|START_ENTITY receptor|appos|Mac-1 required|nsubjpass|receptor required|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Complement receptor 3 -LRB- CR3 , Mac-1 , integrin alpha M beta_2 , CD11b/CD18 -RRB- is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils .
9272575	0	beta_2-adrenergic_receptor	16,42	Gs_alpha	43,51	beta 2-adrenergic receptor	Gs alpha	154	2778	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Activation of a beta_2-adrenergic_receptor / Gs_alpha fusion protein elicits a desensitization-resistant cAMP signal capable of inhibiting proliferation of two cancer cell lines .
12580974	0	beta_2-glycoprotein_I	51,72	Beta2GPI	74,82	beta 2-glycoprotein I	Beta2GPI	350	350	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Paradoxical association between the 316_Trp_to_Ser beta_2-glycoprotein_I -LRB- Beta2GPI -RRB- polymorphism and anti-Beta2GPI antibodies .
8236146	0	beta_2-glycoprotein_I	51,72	factor_Xa	80,89	beta 2-glycoprotein I	factor Xa	350	2159	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Anticardiolipin antibodies block the inhibition by beta_2-glycoprotein_I of the factor_Xa generating activity of platelets .
6375255	0	beta_2-microglobulin	24,44	C1q	15,18	beta 2-microglobulin	C1q	567	712	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of C1q with beta_2-microglobulin .
9780421	0	beta_2-microglobulin	104,124	CD4	149,152	beta 2-microglobulin	CD4	567	920	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Discriminative value for AIDS case of erythrocyte sedimentation rate , immunoglobulins IgA and IgM , and beta_2-microglobulin in combination with the CD4 + lymphocyte count -RSB- .
93282	0	beta_2-microglobulin	33,53	HLA-A	65,70	beta 2-microglobulin	HLA-A	567	3105	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Dissociation and exchange of the beta_2-microglobulin subunit of HLA-A and HLA-B antigens .
11163075	0	beta_2-microglobulin	47,67	HLA-B27	22,29	beta 2-microglobulin	HLA-B27	567	3106	Gene	Gene	association|nmod|START_ENTITY association|nmod|chain chain|compound|END_ENTITY	Strong association of HLA-B27 heavy chain with beta_2-microglobulin .
2259876	0	beta_2-microglobulin	16,36	HLA-B27	40,47	beta 2-microglobulin	HLA-B27	567	3106	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Serum levels of beta_2-microglobulin in HLA-B27 + patients with acute_anterior_uveitis and ankylosing_spondylitis .
7561688	0	beta_2-microglobulin	70,90	HLA-B27	38,45	beta 2-microglobulin	HLA-B27	12010(Tax:10090)	3106	Gene	Gene	lacking|xcomp|START_ENTITY transgenic_mice|acl|lacking transgenic_mice|compound|END_ENTITY	Spontaneous inflammatory_arthritis in HLA-B27 transgenic_mice lacking beta_2-microglobulin : a model of human spondyloarthropathies .
8835498	0	beta_2-microglobulin	21,41	HLA-B27	97,104	beta 2-microglobulin	HLA-B27	567	3106	Gene	Gene	absence|nmod|START_ENTITY increases|nsubj|absence increases|dobj|occurrence occurrence|nmod|ankylosing_enthesopathy ankylosing_enthesopathy|nmod|transgenic_mice transgenic_mice|compound|END_ENTITY	The absence of human beta_2-microglobulin increases the occurrence of ankylosing_enthesopathy in HLA-B27 transgenic_mice .
9246711	0	beta_2-microglobulin	56,76	HLA-B27	48,55	beta 2-microglobulin	HLA-B27	24223(Tax:10116)	3106	Gene	Gene	rats|amod|START_ENTITY /|dobj|rats /|nsubj|inflammation inflammation|nmod|END_ENTITY	Intestinal inflammation and barrier function in HLA-B27 / beta_2-microglobulin transgenic rats .
3096609	0	beta_2-microglobulin	100,120	Pregnancy-specific_beta_1-glycoprotein	0,38	beta 2-microglobulin	Pregnancy-specific beta 1-glycoprotein	567	6667	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Pregnancy-specific_beta_1-glycoprotein in serum in monoclonal_gammopathies : relationship with serum beta_2-microglobulin , and cellular origin .
90611	0	beta_2-microglobulin	116,136	beta_2-microglobulin	18,38	beta 2-microglobulin	beta 2-microglobulin	567	567	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Increased urinary beta_2-microglobulin in cadmium exposure : dose-effect relationship and biological significance of beta_2-microglobulin .
90611	0	beta_2-microglobulin	18,38	beta_2-microglobulin	116,136	beta 2-microglobulin	beta 2-microglobulin	567	567	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Increased urinary beta_2-microglobulin in cadmium exposure : dose-effect relationship and biological significance of beta_2-microglobulin .
9987081	0	beta_2-microglobulin	57,77	cyclooxygenase-2	13,29	beta 2-microglobulin	cyclooxygenase-2	567	5743	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 in human synovial cells by beta_2-microglobulin .
6166622	0	beta_2-microglobulin	6,26	tissue_transglutaminase	45,68	beta 2-microglobulin	tissue transglutaminase	567	7052	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Human beta_2-microglobulin is a substrate of tissue_transglutaminase : polymerization in solution and on the cell surface .
2015789	0	beta_2_and_beta_3	39,56	TGF_beta_1	27,37	beta 2 and beta 3	TGF beta 1	15130(Tax:10090)	21803(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Differential expression of TGF_beta_1 , beta_2_and_beta_3 genes during mouse embryogenesis .
2115549	0	beta_3	83,89	IFN-gamma	150,159	beta 3	IFN-gamma	12297(Tax:10090)	15978(Tax:10090)	Gene	Gene	inhibit|nsubj|START_ENTITY inhibit|nmod|END_ENTITY	Macrophage deactivating factor and transforming growth factors-beta 1 - beta_2 and - beta_3 inhibit induction of macrophage nitrogen_oxide synthesis by IFN-gamma .
7840504	0	beta_3	58,64	beta_2	50,56	beta 3	beta 2	1934	10242	Gene	Gene	Expression|appos|START_ENTITY Expression|amod|END_ENTITY	Expression of transforming growth factors beta_1 , beta_2 , beta_3 in neuroendocrine_tumors of the digestive system .
8896608	0	beta_3	33,39	integrin-associated_protein	57,84	beta 3	integrin-associated protein	1934	961	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	Thrombospondin modulates alpha v beta_3 function through integrin-associated_protein .
1363225	0	beta_3_tubulin	32,46	Ultrabithorax	0,13	beta 3 tubulin	Ultrabithorax	37888(Tax:7227)	42034(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Ultrabithorax is a regulator of beta_3_tubulin expression in the Drosophila visceral mesoderm .
1698797	0	beta_4	39,45	alpha_6	31,38	beta 4	alpha 6	10381	14399(Tax:10090)	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	The alpha_6 beta 1 -LRB- VLA-6 -RRB- and alpha_6 beta_4 protein complexes : tissue distribution and biochemical properties .
8319775	0	beta_4	55,61	alpha_6	47,54	beta 4	alpha 6	140489(Tax:10090)	14399(Tax:10090)	Gene	Gene	integrin|amod|START_ENTITY integrin|amod|END_ENTITY	Redistribution of the hemidesmosome components alpha_6 beta_4 integrin and bullous pemphigoid antigens during epithelial wound healing .
8732671	0	beta_4	50,56	alpha_6	42,49	beta 4	alpha 6	140489(Tax:10090)	14399(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|amod|END_ENTITY	Selective changes in laminin adhesion and alpha_6 beta_4 integrin regulation are associated with the initial steps in keratinocyte maturation .
7490092	0	beta_A2_crystallin	28,46	CRYBA2	53,59	beta A2 crystallin	CRYBA2	282203(Tax:9913)	1412	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the human beta_A2_crystallin gene -LRB- CRYBA2 -RRB- : localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1 .
1424806	0	beta_A4-crystallin	20,38	CRYBA4	45,51	beta A4-crystallin	CRYBA4	1413	1413	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the beta_A4-crystallin gene -LRB- CRYBA4 -RRB- on human chromosome 22 in the region q11 .2 -- > q13 .1 .
22989333	0	beta_amyloid_cleaving_enzyme-1	56,86	BACE1	88,93	beta amyloid cleaving enzyme-1	BACE1	29392(Tax:10116)	29392(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design and validation of bicyclic_iminopyrimidinones as beta_amyloid_cleaving_enzyme-1 -LRB- BACE1 -RRB- inhibitors : conformational constraint to favor a bioactive conformation .
8040342	0	beta_amyloid_peptide	33,53	Apolipoprotein_E	0,16	beta amyloid peptide	Apolipoprotein E	351	348	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Apolipoprotein_E associates with beta_amyloid_peptide of Alzheimer 's _ disease to form novel monofibrils .
8972491	0	beta_c	4,10	GM-CSF	78,84	beta c	GM-CSF	12983(Tax:10090)	12981(Tax:10090)	Gene	Gene	component|amod|START_ENTITY component|nmod|interleukin_3 interleukin_3|appos|END_ENTITY	The beta_c component of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / interleukin_3 -LRB- IL-3 -RRB- / IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression .
10453008	0	beta_c	152,158	IL-3	84,88	beta c	IL-3	1439	3562	Gene	Gene	gene|amod|START_ENTITY receptor|dep|gene essential|iobj|receptor essential|nmod|activity activity|nmod|promoter promoter|nmod|END_ENTITY	A composite C/EBP binding site is essential for the activity of the promoter of the IL-3 / IL-5 / granulocyte-macrophage colony-stimulating factor receptor beta_c gene .
7697542	0	beta_c	40,46	IL-3	23,27	beta c	IL-3	12983(Tax:10090)	16187(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Mice deficient for the IL-3 / GM-CSF/IL -5 beta_c receptor exhibit lung pathology and impaired immune response , while beta IL3 receptor-deficient mice are normal .
8639879	0	beta_c	31,37	IL-3	87,91	beta c	IL-3	12983(Tax:10090)	16187(Tax:10090)	Gene	Gene	truncations|nmod|START_ENTITY truncations|appos|subunit subunit|nmod|END_ENTITY	Extracellular truncations of h beta_c , the common signaling subunit for interleukin-3 -LRB- IL-3 -RRB- , granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , and IL-5 , lead to ligand-independent activation .
8972491	0	beta_c	4,10	IL-3	101,105	beta c	IL-3	12983(Tax:10090)	16187(Tax:10090)	Gene	Gene	component|amod|START_ENTITY component|nmod|interleukin_3 interleukin_3|appos|END_ENTITY	The beta_c component of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- / interleukin_3 -LRB- IL-3 -RRB- / IL-5 receptor interacts with a hybrid GM-CSF/erythropoietin receptor to influence proliferation and beta-globin mRNA expression .
9585433	0	beta_defensin-1	55,70	beta_defensin-1	6,21	beta defensin-1	beta defensin-1	1672	1672	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Mouse beta_defensin-1 is a functional homolog of human beta_defensin-1 .
9585433	0	beta_defensin-1	6,21	beta_defensin-1	55,70	beta defensin-1	beta defensin-1	1672	1672	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Mouse beta_defensin-1 is a functional homolog of human beta_defensin-1 .
10458478	0	beta_type_platelet-derived_growth_factor_receptor	155,204	PDGFR-beta	206,216	beta type platelet-derived growth factor receptor	PDGFR-beta	24629(Tax:10116)	24629(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Better-surviving liver grafts by the injection of anti-CD2 antibody : the important roles of host CD8 + and CD2 + CD28 + T cells in chronic graft rejection and beta_type_platelet-derived_growth_factor_receptor -LRB- PDGFR-beta -RRB- expression on apoptotic liver grafts .
18236212	0	betaglycan	35,45	TGFBR3	27,33	betaglycan	TGFBR3	21814(Tax:10090)	21814(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of TGFBR3 -LRB- betaglycan -RRB- in mouse ovary and testis during gonadogenesis .
12568406	0	betaglycan	81,91	TGFbeta	116,123	betaglycan	TGFbeta	7049	7040	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Endoglin is expressed on human chondrocytes and forms a heteromeric complex with betaglycan in a ligand and type II TGFbeta receptor independent manner .
8226781	0	betaglycan	64,74	transforming_growth_factor_beta	16,47	betaglycan	transforming growth factor beta	7049	7040	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Localization of transforming_growth_factor_beta binding site in betaglycan .
15899806	0	betaig-h3	72,81	FAS1	57,61	betaig-h3	FAS1	7045	355	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Regulation of tumor angiogenesis by fastatin , the fourth FAS1 domain of betaig-h3 , via alphavbeta3 integrin .
11095060	0	betaig-h3	34,43	TGFBI	27,32	betaig-h3	TGFBI	7045	7045	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Six different mutations of TGFBI -LRB- betaig-h3 , keratoepithelin -RRB- gene found in Japanese corneal_dystrophies .
18245446	0	betaig-h3	29,38	TGFBI	39,44	betaig-h3	TGFBI	7045	7045	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Extracellular matrix protein betaig-h3 / TGFBI promotes metastasis of colon_cancer by enhancing cell extravasation .
21459558	0	betaine-GABA_transporter	16,40	BGT1	42,46	betaine-GABA transporter	BGT1	14411(Tax:10090)	14411(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion of the betaine-GABA_transporter -LRB- BGT1 ; slc6a12 -RRB- gene does not affect seizure thresholds of adult mice .
22138536	0	betaine-homocysteine_methyltransferase	57,95	BHMT	97,101	betaine-homocysteine methyltransferase	BHMT	635	635	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A splicing variant leads to complete loss of function of betaine-homocysteine_methyltransferase -LRB- BHMT -RRB- gene in hepatocellular_carcinoma .
17121585	0	bfl-1	41,46	Bcl-2	21,26	bfl-1	Bcl-2	597	596	Gene	Gene	Polymorphisms|amod|START_ENTITY Polymorphisms|nmod|member member|compound|END_ENTITY	Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic_dermatitis .
8752150	0	bfl-1	0,5	bcl-2	9,14	bfl-1	bcl-2	597	596	Gene	Gene	START_ENTITY|appos|homologue homologue|amod|END_ENTITY	bfl-1 , a bcl-2 homologue , suppresses p53-induced apoptosis and exhibits potent cooperative transforming activity .
9757570	1	bgl1	96,100	beta-glucosidase_1	76,94	bgl1	beta-glucosidase 1	851007(Tax:4932)	851007(Tax:4932)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	F-50 cellobiohydrolase I -LRB- cbhI -RRB- and beta-glucosidase_1 -LRB- bgl1 -RRB- genes by Saccharomyces_cerevisiae .
20215348	0	bicaudal_C	24,34	polycystin_2	45,57	bicaudal C	polycystin 2	83675(Tax:10090)	18764(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The RNA-binding protein bicaudal_C regulates polycystin_2 in the kidney by antagonizing miR-17 activity .
21205795	0	bicd-1	11,17	Bicaudal_D	69,79	bicd-1	Bicaudal D	183417(Tax:6239)	35051(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	C. _ elegans bicd-1 , homolog of the Drosophila dynein accessory factor Bicaudal_D , regulates the branching of PVD sensory neuron dendrites .
11929871	0	bid	50,53	Bak	101,104	bid	Bak	637	578	Gene	Gene	collaboration|nsubj|START_ENTITY collaboration|nmod|END_ENTITY	Bcl-2 family member Bfl-1 / A1 sequesters truncated bid to inhibit is collaboration with pro-apoptotic Bak or Bax .
23418437	0	bid	106,109	Caspase-8	0,9	bid	Caspase-8	637	841	Gene	Gene	platform|nmod|START_ENTITY provides|dobj|platform provides|nsubj|vesicles vesicles|nummod|END_ENTITY	Caspase-8 binding to cardiolipin in giant unilamellar vesicles provides a functional docking platform for bid .
12213439	0	bid	27,30	caspase-1	34,43	bid	caspase-1	12122(Tax:10090)	12362(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS .
10548502	0	bid	25,28	caspase-8	32,41	bid	caspase-8	637	841	Gene	Gene	cleavage|nmod|START_ENTITY causes|dobj|cleavage causes|nmod|END_ENTITY	TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells .
12754217	0	bid	103,106	caspase-8	93,102	bid	caspase-8	637	841	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8 / bid pathway .
10837470	0	bid	46,49	p38	0,3	bid	p38	637	1432	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	p38 mitogen-activated protein kinase mediates bid cleavage , mitochondrial_dysfunction , and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen_peroxide .
25889002	0	big-H3	19,25	TGFBI	12,17	big-H3	TGFBI	21810(Tax:10090)	21810(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of TGFBI -LRB- big-H3 -RRB- in gastrointestinal tract tumorigenesis .
25889002	0	big-H3	19,25	TGFBI	12,17	big-H3	TGFBI	21810(Tax:10090)	21810(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of TGFBI -LRB- big-H3 -RRB- in gastrointestinal tract tumorigenesis .
16051186	0	biglycan	63,71	Adiponectin	0,11	biglycan	Adiponectin	633	9370	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Adiponectin inhibits the binding of low-density lipoprotein to biglycan , a vascular proteoglycan .
9521506	0	biglycan	14,22	CSF-1	53,58	biglycan	CSF-1	633	1435	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of biglycan , decorin and proteoglycan-100 / CSF-1 in normal and fibrotic human liver .
21084753	0	biglycan	17,25	CXCL13	77,83	biglycan	CXCL13	12111(Tax:10090)	55985(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus_nephritis .
15995169	0	biglycan	17,25	Endostatin	0,10	biglycan	Endostatin	12111(Tax:10090)	12822(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial_matrix during atherosclerosis .
22582394	0	biglycan	38,46	HER-2	0,5	biglycan	HER-2	633	2064	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|compound|END_ENTITY	HER-2 / neu-mediated down-regulation of biglycan associated with altered growth properties .
24875140	0	biglycan	8,16	ICAM-1	43,49	biglycan	ICAM-1	633	3383	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|nmod|END_ENTITY	Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway .
21913799	0	biglycan	17,25	TGF-b	0,5	biglycan	TGF-b	633	7040	Gene	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	TGF-b stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle .
20213272	0	biglycan	20,28	TGF-beta	0,8	biglycan	TGF-beta	633	7040	Gene	Gene	synthesis|compound|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	TGF-beta stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2 .
24875140	0	biglycan	8,16	TLR2/4	109,115	biglycan	TLR2/4	633	7097;7099	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Soluble biglycan induces the production of ICAM-1 and MCP-1 in human aortic valve interstitial cells through TLR2/4 and the ERK1/2 pathway .
15546867	0	biglycan	134,142	Transforming_growth_factor-beta	0,31	biglycan	Transforming growth factor-beta	633	7040	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression mediates|dobj|induction I|acl:relcl|mediates type|dep|I type|amod|END_ENTITY	Transforming_growth_factor-beta -LRB- TGF-beta -RRB- type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta .
15372625	0	biglycan	47,55	Transforming_growth_factor_beta	0,31	biglycan	Transforming growth factor beta	633	7040	Gene	Gene	expression|amod|START_ENTITY stimulation|nmod|expression stimulation|compound|END_ENTITY	Transforming_growth_factor_beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors .
9421237	0	biglycan	41,49	c-Krox	106,112	biglycan	c-Krox	633	51043	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Functional characterization of the human biglycan 5 ' - flanking DNA and binding of the transcription factor c-Krox .
14964452	0	biglycan	25,33	decorin	68,75	biglycan	decorin	633	1634	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular_disease .
12140283	0	biglycan	35,43	transforming_growth_factor-beta	63,94	biglycan	transforming growth factor-beta	633	7040	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Smad4/DPC4-dependent regulation of biglycan gene expression by transforming_growth_factor-beta in pancreatic_tumor cells .
12538652	0	biglycan	14,22	transforming_growth_factor-beta	42,73	biglycan	transforming growth factor-beta	633	7040	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of biglycan gene expression by transforming_growth_factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling .
16051607	0	biglycan	42,50	transforming_growth_factor-beta	70,101	biglycan	transforming growth factor-beta	633	7040	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming_growth_factor-beta .
10576418	0	biglycan	79,87	transforming_growth_factor-beta1	11,43	biglycan	transforming growth factor-beta1	25181(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effects of transforming_growth_factor-beta1 on the gene expression of decorin , biglycan , and alkaline phosphatase in osteoblast precursor cells and more differentiated osteoblast cells .
1383209	0	bikunin	130,137	alpha_1-microglobulin	108,129	bikunin	alpha 1-microglobulin	259	259	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A potent enhancer made of clustered liver-specific elements in the transcription control sequences of human alpha_1-microglobulin / bikunin gene .
8889810	0	bikunin	57,64	inter-alpha-trypsin_inhibitor_light_chain	14,55	bikunin	inter-alpha-trypsin inhibitor light chain	259	259	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of inter-alpha-trypsin_inhibitor_light_chain -LRB- bikunin -RRB- in human pancreas .
18270374	0	bile_salt_export_pump	59,80	Liver_receptor_homolog_1	0,24	bile salt export pump	Liver receptor homolog 1	8647	2494	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Liver_receptor_homolog_1 transcriptionally regulates human bile_salt_export_pump expression .
7517208	0	biliary_glycoprotein	20,40	BGP	42,45	biliary glycoprotein	BGP	634	634	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	The N-domain of the biliary_glycoprotein -LRB- BGP -RRB- adhesion molecule mediates homotypic binding : domain interactions and epitope analysis of BGPc .
1653760	0	biliary_glycoprotein	10,30	Bgp	37,40	biliary glycoprotein	Bgp	634	26365(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse biliary_glycoprotein gene -LRB- Bgp -RRB- : partial nucleotide sequence , expression , and chromosomal assignment .
8500759	0	biliary_glycoprotein	63,83	Bgp	18,21	biliary glycoprotein	Bgp	634	26365(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Expression of the Bgp gene and characterization of mouse colon biliary_glycoprotein isoforms .
1998947	0	biliary_glycoprotein	118,138	carcinoembryonic_antigen	156,180	biliary glycoprotein	carcinoembryonic antigen	634	1084	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Identification of membrane antigens in granulocytes and colonic_carcinoma cells by a monoclonal antibody specific for biliary_glycoprotein , a member of the carcinoembryonic_antigen family .
8910434	0	biliary_glycoprotein	59,79	interferon_regulatory_factor-1	8,38	biliary glycoprotein	interferon regulatory factor-1	634	3659	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Role of interferon_regulatory_factor-1 in the induction of biliary_glycoprotein -LRB- cell CAM-1 -RRB- by interferon-gamma .
6119767	0	biliary_glycoprotein_I	15,37	gamma-glutamyltranspeptidase	87,115	biliary glycoprotein I	gamma-glutamyltranspeptidase	634	92086	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	Serum level of biliary_glycoprotein_I , a determinant of cholestasis , of similar use as gamma-glutamyltranspeptidase .
7656592	0	biliverdin-IX_beta_reductase	32,60	BLVRB	67,72	biliverdin-IX beta reductase	BLVRB	645	645	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the newly identified biliverdin-IX_beta_reductase gene -LRB- BLVRB -RRB- to human chromosome 19q13 .13 -- > q13 .2 by fluorescence in situ hybridization .
15870194	0	biliverdin_reductase	6,26	insulin_receptor	44,60	biliverdin reductase	insulin receptor	644	3643	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	Human biliverdin_reductase : a member of the insulin_receptor substrate family with serine/threonine/tyrosine kinase activity .
26708147	0	biliverdin_reductase_B	28,50	MicroRNA-127-5p	0,15	biliverdin reductase B	MicroRNA-127-5p	645	100302123	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-127-5p targets the biliverdin_reductase_B / nuclear factor-kB pathway to suppress cell growth in hepatocellular_carcinoma cells .
11193044	0	bim	50,53	Bcl-2	30,35	bim	Bcl-2	12125(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|member member|compound|END_ENTITY	The role of the pro-apoptotic Bcl-2 family member bim in physiological cell death .
26084664	0	binder_of_SPerm_5	57,74	BSP5	76,80	binder of SPerm 5	BSP5	317699(Tax:9913)	317699(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Functional characterization of the domains of the bovine binder_of_SPerm_5 -LRB- BSP5 -RRB- protein .
11827295	0	bisphenol-A	15,26	BPA	28,31	bisphenol-A	BPA	667	667	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|appos|END_ENTITY	Degradation of bisphenol-A -LRB- BPA -RRB- in the presence of reactive oxygen species and its acceleration by lipids and sodium_chloride .
18967809	0	bisphenol_A	17,28	BPA	30,33	bisphenol A	BPA	667	667	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of bisphenol_A -LRB- BPA -RRB- in the presence of phenol by first-derivative fluorescence following micro liquid-liquid extraction -LRB- MLLE -RRB- .
15147973	0	bisphenol_A	178,189	HIF-1alpha	139,149	bisphenol A	HIF-1alpha	667	3091	Gene	Gene	requirement|nmod|START_ENTITY END_ENTITY|dep|requirement	Bisphenol_A , an environmental endocrine-disrupting chemical , inhibits hypoxic response via degradation of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- : structural requirement of bisphenol_A for degradation of HIF-1alpha .
15147973	0	bisphenol_A	178,189	HIF-1alpha	209,219	bisphenol A	HIF-1alpha	667	3091	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	Bisphenol_A , an environmental endocrine-disrupting chemical , inhibits hypoxic response via degradation of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- : structural requirement of bisphenol_A for degradation of HIF-1alpha .
12021184	0	bisphenol_a	20,31	Nur77	64,69	bisphenol a	Nur77	13518(Tax:10090)	15370(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Endocrine disrupter bisphenol_a induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cells .
15054810	0	bisphosphoglycerate_mutase	22,48	glucose-6-phosphate_dehydrogenase	76,109	bisphosphoglycerate mutase	glucose-6-phosphate dehydrogenase	669	2539	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Erythrocytosis due to bisphosphoglycerate_mutase deficiency with concurrent glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- deficiency .
3081265	0	bithorax	39,47	Polycomb	71,79	bithorax	Polycomb	42034(Tax:7227)	40358(Tax:7227)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila .
7900984	0	bithorax	51,59	Trithorax	0,9	bithorax	Trithorax	42034(Tax:7227)	41737(Tax:7227)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific , parasegment-specific and promoter-specific effects on each .
17246389	0	bithorax	65,73	trithorax	78,87	bithorax	trithorax	42034(Tax:7227)	41737(Tax:7227)	Gene	Gene	Locus|amod|START_ENTITY Locus|dep|END_ENTITY	Homoeosis in Drosophila : The Lethal Syndrome of the Regulator of bithorax -LRB- or trithorax -RRB- Locus and Its Interaction with Other Homoeotic Loci .
11741549	0	bithorax_complex	123,139	Abd-B	105,110	bithorax complex	Abd-B	42034(Tax:7227)	47763(Tax:7227)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Replacement of Fab-7 by the gypsy or scs insulator disrupts long-distance regulatory interactions in the Abd-B gene of the bithorax_complex .
8985187	0	bithorax_complex	25,41	Fab-7	4,9	bithorax complex	Fab-7	42034(Tax:7227)	5657585	Gene	Gene	element|nmod|START_ENTITY element|compound|END_ENTITY	The Fab-7 element of the bithorax_complex attenuates enhancer-promoter interactions in the Drosophila embryo .
19651300	0	bithorax_complex	4,20	Hox	50,53	bithorax complex	Hox	42034(Tax:7227)	42536(Tax:7227)	Gene	Gene	START_ENTITY|nmod|Drosophila Drosophila|dep|cluster cluster|compound|END_ENTITY	The bithorax_complex of Drosophila an exceptional Hox cluster .
1358590	0	bithorax_complex	65,81	abd-A	45,50	bithorax complex	abd-A	42034(Tax:7227)	42037(Tax:7227)	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Gonad formation and development requires the abd-A domain of the bithorax_complex in Drosophila_melanogaster .
1352698	0	bithorax_complex	104,120	abdominal-A	78,89	bithorax complex	abdominal-A	42034(Tax:7227)	42037(Tax:7227)	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Segmental_determination in Drosophila central nervous system : analysis of the abdominal-A region of the bithorax_complex .
7713434	0	bithorax_complex	44,60	iab-5	20,25	bithorax complex	iab-5	42034(Tax:7227)	47763(Tax:7227)	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Transvection in the iab-5 ,6,7 region of the bithorax_complex of Drosophila : homology independent interactions in trans .
10545463	0	bithorax_complex	49,65	mcp	4,7	bithorax complex	mcp	42034(Tax:7227)	44013(Tax:7227)	Gene	Gene	element|nmod|START_ENTITY element|compound|END_ENTITY	The mcp element from the Drosophila_melanogaster bithorax_complex mediates long-distance regulatory interactions .
22170571	0	bla	36,39	CTX-M-1	42,49	bla	CTX-M-1	3244915(Tax:562)	13909205	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Complex class 1 integron containing bla -LRB- CTX-M-1 -RRB- genes isolated from Escherichia_coli : a potentially novel resistant gene-capturing tool kit .
22978676	0	bla	34,37	KPC-2	38,43	bla	KPC-2	1238792(Tax:573)	13914015	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the bla -LRB- KPC-2 -RRB- gene in clinical isolates of carbapenem-resistant Klebsiella_pneumoniae from the pediatric wards of a Chinese hospital .
19961397	0	bla	16,19	bla	26,29	bla	bla	1238792(Tax:573)	1238792(Tax:573)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of bla -LRB- TEM -RRB- , bla -LRB- SHV -RRB- , bla -LRB- CTX-M -RRB- genes among clinical isolates of Klebsiella_pneumoniae at Labbafinejad Hospital , Tehran , Iran .
19961397	0	bla	16,19	bla	36,39	bla	bla	1238792(Tax:573)	1238792(Tax:573)	Gene	Gene	Distribution|nmod|START_ENTITY END_ENTITY|nsubj|Distribution	Distribution of bla -LRB- TEM -RRB- , bla -LRB- SHV -RRB- , bla -LRB- CTX-M -RRB- genes among clinical isolates of Klebsiella_pneumoniae at Labbafinejad Hospital , Tehran , Iran .
19961397	0	bla	26,29	bla	16,19	bla	bla	1238792(Tax:573)	1238792(Tax:573)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of bla -LRB- TEM -RRB- , bla -LRB- SHV -RRB- , bla -LRB- CTX-M -RRB- genes among clinical isolates of Klebsiella_pneumoniae at Labbafinejad Hospital , Tehran , Iran .
19961397	0	bla	36,39	bla	16,19	bla	bla	1238792(Tax:573)	1238792(Tax:573)	Gene	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution of bla -LRB- TEM -RRB- , bla -LRB- SHV -RRB- , bla -LRB- CTX-M -RRB- genes among clinical isolates of Klebsiella_pneumoniae at Labbafinejad Hospital , Tehran , Iran .
26830052	0	blaCTX-M-15	0,11	ESBL	58,62	blaCTX-M-15	ESBL	9538104	13906541	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	blaCTX-M-15 carried by IncF-type plasmids is the dominant ESBL gene in Escherichia_coli and Klebsiella_pneumoniae at a hospital in Ghana .
8835524	0	bm	48,50	brachymorphic	33,46	bm	brachymorphic	23972(Tax:10090)	23972(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Molecular markers near the mouse brachymorphic -LRB- bm -RRB- gene , which affects connective tissues and bleeding time .
21076970	0	bmal1	78,83	per2	72,76	bmal1	per2	29657(Tax:10116)	63840(Tax:10116)	Gene	Gene	ppara|dep|START_ENTITY ppara|compound|END_ENTITY	Effect of phase delay lighting rotation schedule on daily expression of per2 , bmal1 , rev-erba , ppara , and pdk4 genes in the heart and liver of Wistar_rats .
8764984	0	bmh1	82,86	bmh2	87,91	bmh1	bmh2	856924(Tax:4932)	851676(Tax:4932)	Gene	Gene	disruption|amod|START_ENTITY disruption|amod|END_ENTITY	Four Arabidopsis_thaliana 14-3-3 protein isoforms can complement the lethal yeast bmh1 bmh2 double disruption .
8764984	0	bmh2	87,91	bmh1	82,86	bmh2	bmh1	851676(Tax:4932)	856924(Tax:4932)	Gene	Gene	disruption|amod|START_ENTITY disruption|amod|END_ENTITY	Four Arabidopsis_thaliana 14-3-3 protein isoforms can complement the lethal yeast bmh1 bmh2 double disruption .
11355949	0	bmi-1	4,9	INK4A-ARF	100,109	bmi-1	INK4A-ARF	648	1029	Gene	Gene	oncoprotein|amod|START_ENTITY expressed|nsubjpass|oncoprotein expressed|nmod|expression expression|compound|END_ENTITY	The bmi-1 oncoprotein is differentially expressed in non-small_cell_lung_cancer and correlates with INK4A-ARF locus expression .
17442375	0	bmi-1	113,118	p16	16,19	bmi-1	p16	648	1029	Gene	Gene	oncogenes|amod|START_ENTITY syndrome|nmod|oncogenes syndrome|nsubj|Consequences Consequences|nmod|inactivation inactivation|amod|END_ENTITY	Consequences of p16 tumor suppressor gene inactivation in mycosis fungoides and S zary syndrome and role of the bmi-1 and ras oncogenes in disease progression .
23092893	0	bmi1	49,53	Akt	0,3	bmi1	Akt	648	207	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus .
12835381	0	bmp2b	27,32	bozozok	0,7	bmp2b	bozozok	30632(Tax:7955)	30170(Tax:7955)	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish .
2468544	0	bombesin	10,18	GRP	50,53	bombesin	GRP	2922	2922	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of bombesin and its mammalian counterpart , GRP , on exocrine pancreas in the rat .
15872357	0	bombesin	23,31	GRP-R	57,62	bombesin	GRP-R	2922	2925	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs .
7883024	0	bombesin	37,45	Gastrin	0,7	bombesin	Gastrin	2922	2520	Gene	Gene	sites|amod|START_ENTITY releasing|dobj|sites END_ENTITY|acl|releasing	Gastrin releasing peptide-preferring bombesin binding sites in human lung .
14673956	0	bombesin	93,101	IL-1beta	120,128	bombesin	IL-1beta	2922	3553	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Proliferation of prostate_cancer cells and activity of neutral_endopeptidase is regulated by bombesin and IL-1beta with IL-1beta acting as a modulator of cellular differentiation .
9087795	0	bombesin	29,37	PC3	77,80	bombesin	PC3	2922	57332	Gene	Gene	START_ENTITY|nmod|proliferation proliferation|nmod|END_ENTITY	In vitro characterization of bombesin and calcitonin on the proliferation of PC3 , DU 145 and LNCaP cancer prostatic cell lines .
7977748	0	bombesin	43,51	STC-1	55,60	bombesin	STC-1	2922	6781	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Regulation of cholecystokinin secretion by bombesin in STC-1 cells .
1972871	0	bombesin	22,30	Somatostatin	0,12	bombesin	Somatostatin	2922	6750	Gene	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Somatostatin mediates bombesin inhibition of chloride secretion by rectal gland .
6840407	0	bombesin	23,31	cationic_trypsinogen	41,61	bombesin	cationic trypsinogen	2922	5644	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	Dose-related effect of bombesin on serum cationic_trypsinogen levels .
7977748	0	bombesin	43,51	cholecystokinin	14,29	bombesin	cholecystokinin	2922	885	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of cholecystokinin secretion by bombesin in STC-1 cells .
11798599	0	bombesin	15,23	cyclin_D1	27,36	bombesin	cyclin D1	2922	595	Gene	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|END_ENTITY	-LSB- The effect of bombesin on cyclin_D1 / CDK4 of immortalized human gastric epithelial cell line -RSB- .
1190200	0	bombesin	10,18	gastrin	35,42	bombesin	gastrin	2922	2520	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bombesin on extragastric gastrin in man .
1972573	0	bombesin	20,28	gastrin	56,63	bombesin	gastrin	2922	2520	Gene	Gene	receptors|compound|START_ENTITY Characterization|nmod|receptors Characterization|nmod|cells cells|compound|END_ENTITY	Characterization of bombesin receptors on canine antral gastrin cells .
2092327	0	bombesin	81,89	gastrin	34,41	bombesin	gastrin	2922	2520	Gene	Gene	analogs|compound|START_ENTITY release|nmod|analogs release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of bombesin-stimulated gastrin release from isolated human G cells by bombesin analogs .
2483358	0	bombesin	82,90	gastrin	34,41	bombesin	gastrin	2922	2520	Gene	Gene	antagonists|compound|START_ENTITY release|nmod|antagonists release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of bombesin-stimulated gastrin release from isolated canine G cells by bombesin antagonists .
2880870	0	bombesin	34,42	gastrin	15,22	bombesin	gastrin	2922	2520	Gene	Gene	peptides|compound|START_ENTITY release|nmod|peptides release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of gastrin release by bombesin and canine gastrin-releasing peptides .
3349493	0	bombesin	28,36	gastrin	48,55	bombesin	gastrin	2922	2520	Gene	Gene	START_ENTITY|dobj|concentrations concentrations|compound|END_ENTITY	Plasma gastrin responses to bombesin and antral gastrin concentrations in patients with the intestinal type of gastric_cancer .
4011955	0	bombesin	14,22	gastrin	45,52	bombesin	gastrin	2922	2520	Gene	Gene	Evidence|dep|START_ENTITY releases|nsubj|Evidence releases|dobj|END_ENTITY	Evidence that bombesin releases extragastric gastrin in man .
6647889	0	bombesin	26,34	gastrin	76,83	bombesin	gastrin	2922	2520	Gene	Gene	atropine|nmod|START_ENTITY effect|nmod|atropine stimulated|nsubj|effect stimulated|dobj|release release|compound|END_ENTITY	The effect of atropine on bombesin and gastrin_releasing_peptide stimulated gastrin , pancreatic_polypeptide and neurotensin release in man .
7067582	0	bombesin	27,35	gastrin	6,13	bombesin	gastrin	2922	2520	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Serum gastrin responses to bombesin and food in patients with hypergastrinemia .
7255766	0	bombesin	16,24	gastrin	50,57	bombesin	gastrin	2922	2520	Gene	Gene	potency|nmod|START_ENTITY potency|nmod|release release|compound|END_ENTITY	High potency of bombesin for stimulation of human gastrin release and gastric_acid secretion .
2166149	0	bombesin	47,55	gastrin-releasing_peptide	14,39	bombesin	gastrin-releasing peptide	2922	2922	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of gastrin-releasing_peptide -LRB- human bombesin -RRB- gene in large cell undifferentiated carcinoma_of_the_lung .
6489083	0	bombesin	23,31	gastrin-releasing_peptide	44,69	bombesin	gastrin-releasing peptide	2922	610154(Tax:9615)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Comparative effects of bombesin and porcine gastrin-releasing_peptide in the dog .
7728752	0	bombesin	82,90	gastrin-releasing_peptide_receptor	18,52	bombesin	gastrin-releasing peptide receptor	2922	2925	Gene	Gene	confers|xcomp|START_ENTITY confers|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the gastrin-releasing_peptide_receptor confers a growth response to bombesin in immortalized human bronchial epithelial cells .
3226021	0	bombesin	23,31	gastrin_releasing_peptide	41,66	bombesin	gastrin releasing peptide	2922	2922	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- Contractile effect of bombesin and GRP -LRB- gastrin_releasing_peptide -RRB- related peptides on bladder smooth muscle -RSB- .
7166510	0	bombesin	16,24	gastrin_releasing_peptide	34,59	bombesin	gastrin releasing peptide	2922	2922	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of bombesin and GRP -LRB- gastrin_releasing_peptide -RRB- sequences in gut nerves or endocrine cells .
7698316	0	bombesin	32,40	phospholipase_D	69,84	bombesin	phospholipase D	2922	2822	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Heterologous desensitization of bombesin - and vasopressin-stimulated phospholipase_D activity in Swiss 3T3 fibroblasts .
2844832	0	bombesin	53,61	thrombin	69,77	bombesin	thrombin	2922	2147	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Differential response of normal human fibroblasts to bombesin versus thrombin .
17355223	0	bombesin_receptor_subtype_3	33,60	PPARalpha	0,9	bombesin receptor subtype 3	PPARalpha	680	5465	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	PPARalpha and AP-2alpha regulate bombesin_receptor_subtype_3 expression in ozone-stressed bronchial epithelial cells .
23530031	0	bone-restricted_IFITM-like	18,44	Bril	46,50	bone-restricted IFITM-like	Bril	387733	387733	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of the bone-restricted_IFITM-like -LRB- Bril -RRB- gene transcription by Sp and Gli family members and CpG methylation .
2180981	0	bone_Gla_protein	41,57	GH	27,29	bone Gla protein	GH	632	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on plasma bone_Gla_protein in GH-deficient adults .
2370291	0	bone_Gla_protein	6,22	GH	62,64	bone Gla protein	GH	632	2688	Gene	Gene	START_ENTITY|dep|marker marker|nmod|deficiency deficiency|appos|END_ENTITY	Serum bone_Gla_protein : a potential marker of growth_hormone -LRB- GH -RRB- deficiency and the response to GH therapy .
2019266	0	bone_Gla_protein	73,89	Tumor_necrosis_factor-alpha	0,27	bone Gla protein	Tumor necrosis factor-alpha	25295(Tax:10116)	24835(Tax:10116)	Gene	Gene	synthesis|compound|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits 1,25-dihydroxyvitamin _ D3-stimulated bone_Gla_protein synthesis in rat_osteosarcoma cells -LRB- ROS 17/2 .8 -RRB- by a pretranslational mechanism .
2180981	0	bone_Gla_protein	41,57	growth_hormone	11,25	bone Gla protein	growth hormone	632	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on plasma bone_Gla_protein in GH-deficient adults .
2370291	0	bone_Gla_protein	6,22	growth_hormone	46,60	bone Gla protein	growth hormone	632	2688	Gene	Gene	START_ENTITY|dep|marker marker|nmod|deficiency deficiency|amod|END_ENTITY	Serum bone_Gla_protein : a potential marker of growth_hormone -LRB- GH -RRB- deficiency and the response to GH therapy .
18684712	0	bone_morphogenetic_protein	73,99	ALK2	25,29	bone morphogenetic protein	ALK2	649	90	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone_morphogenetic_protein signaling in fibrodysplasia ossificans progressiva .
22799562	0	bone_morphogenetic_protein	71,97	Alk1	17,21	bone morphogenetic protein	Alk1	649	94	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Structure of the Alk1 extracellular domain and characterization of its bone_morphogenetic_protein -LRB- BMP -RRB- binding properties .
18386821	0	bone_morphogenetic_protein	39,65	BAMBI	75,80	bone morphogenetic protein	BAMBI	649	25805	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression and regulation of the decoy bone_morphogenetic_protein receptor BAMBI in the developing avian face .
11321800	0	bone_morphogenetic_protein	69,95	BMP	97,100	bone morphogenetic protein	BMP	649	649	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Experimental study of secondary bone graft of alveolar_clefts using bone_morphogenetic_protein -LRB- BMP -RRB- -RSB- .
15192043	0	bone_morphogenetic_protein	24,50	BMP	52,55	bone morphogenetic protein	BMP	649	649	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Characterization of the bone_morphogenetic_protein -LRB- BMP -RRB- system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary_pulmonary_hypertension : roles of BMP type IB receptor -LRB- activin receptor-like kinase-6 -RRB- in the mitotic action .
15775299	0	bone_morphogenetic_protein	25,51	BMP	53,56	bone morphogenetic protein	BMP	649	649	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Bone regeneration using bone_morphogenetic_protein -LRB- BMP -RRB- -RSB- .
17472960	0	bone_morphogenetic_protein	55,81	BMP	83,86	bone morphogenetic protein	BMP	649	649	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Repulsive guidance molecule RGMa alters utilization of bone_morphogenetic_protein -LRB- BMP -RRB- type II receptors by BMP2 and BMP4 .
2060214	0	bone_morphogenetic_protein	12,38	BMP	40,43	bone morphogenetic protein	BMP	649	649	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of bone_morphogenetic_protein -LRB- BMP -RRB- derived from human and bovine bone matrix .
2195159	0	bone_morphogenetic_protein	32,58	BMP	60,63	bone morphogenetic protein	BMP	649	649	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of bone_morphogenetic_protein -LRB- BMP -RRB- in osteosarcoma .
22961979	0	bone_morphogenetic_protein	68,94	BMP	96,99	bone morphogenetic protein	BMP	649	649	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	SMAD versus non-SMAD signaling is determined by lateral mobility of bone_morphogenetic_protein -LRB- BMP -RRB- receptors .
25506972	0	bone_morphogenetic_protein	43,69	BMP	80,83	bone morphogenetic protein	BMP	649	649	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Development of a potent and ALK2 selective bone_morphogenetic_protein receptor -LRB- BMP -RRB- inhibitor A fast-track chemistry effort was initiated to evaluate the structure-activity relationship of the 3 - and 6-positions of the pyrazolo -LSB- 1,5-a -RSB- pyrimidine scaffold of the known bone_morphogenetic_protein -LRB- BMP -RRB- inhibitors .
7530996	0	bone_morphogenetic_protein	34,60	BMP	62,65	bone morphogenetic protein	BMP	649	649	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Immunohistochemical evaluation of bone_morphogenetic_protein -LRB- BMP -RRB- in mixed_tumor of skin .
8301605	0	bone_morphogenetic_protein	36,62	BMP	64,67	bone morphogenetic protein	BMP	649	649	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of bone_morphogenetic_protein -LRB- BMP -RRB- in calcifying fibrous_epulis .
8935072	0	bone_morphogenetic_protein	24,50	BMP	52,55	bone morphogenetic protein	BMP	649	649	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The inductive effect of bone_morphogenetic_protein -LRB- BMP -RRB- on human periodontal fibroblast-like cells in vitro .
20926379	0	bone_morphogenetic_protein	39,65	CRMP2	19,24	bone morphogenetic protein	CRMP2	649	1808	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	The suppression of CRMP2 expression by bone_morphogenetic_protein -LRB- BMP -RRB- - SMAD gradient signaling controls multiple stages of neuronal development .
17203235	0	bone_morphogenetic_protein	60,86	Hepatocyte_growth_factor	0,24	bone morphogenetic protein	Hepatocyte growth factor	649	15234(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor up-regulates the expression of the bone_morphogenetic_protein -LRB- BMP -RRB- receptors , BMPR-IB and BMPR-II , in human prostate_cancer cells .
26701726	0	bone_morphogenetic_protein	45,71	LKB1	19,23	bone morphogenetic protein	LKB1	649	6794	Gene	Gene	receptor|compound|START_ENTITY regulates|dobj|receptor regulates|nsubj|END_ENTITY	The protein kinase LKB1 negatively regulates bone_morphogenetic_protein receptor signaling .
20054823	0	bone_morphogenetic_protein	63,89	LL-37	25,30	bone morphogenetic protein	LL-37	649	820	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The host defense peptide LL-37 activates the tumor-suppressing bone_morphogenetic_protein signaling via inhibition of proteasome in gastric_cancer cells .
16373339	0	bone_morphogenetic_protein	14,40	OAZ	0,3	bone morphogenetic protein	OAZ	649	4946	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	OAZ regulates bone_morphogenetic_protein signaling through Smad6 activation .
19018761	0	bone_morphogenetic_protein	64,90	S100P	42,47	bone morphogenetic protein	S100P	649	6286	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the calcium-binding protein S100P is regulated by bone_morphogenetic_protein in pancreatic duct epithelial cell lines .
24308972	0	bone_morphogenetic_protein	6,32	Smad2	51,56	bone morphogenetic protein	Smad2	649	4087	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Novel bone_morphogenetic_protein signaling through Smad2 and Smad3 to regulate cancer progression and development .
16373339	0	bone_morphogenetic_protein	14,40	Smad6	59,64	bone morphogenetic protein	Smad6	649	4091	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|amod|END_ENTITY	OAZ regulates bone_morphogenetic_protein signaling through Smad6 activation .
17493940	0	bone_morphogenetic_protein	41,67	Smad6	32,37	bone morphogenetic protein	Smad6	649	4091	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Selective inhibitory effects of Smad6 on bone_morphogenetic_protein type I receptors .
18319260	0	bone_morphogenetic_protein	48,74	follistatin	94,105	bone morphogenetic protein	follistatin	649	10468	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	GLI2-specific transcriptional activation of the bone_morphogenetic_protein / activin antagonist follistatin in human epidermal cells .
9228090	0	bone_morphogenetic_protein-1	46,74	Transforming_growth_factor-beta	0,31	bone morphogenetic protein-1	Transforming growth factor-beta	649	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Transforming_growth_factor-beta regulation of bone_morphogenetic_protein-1 / procollagen_C-proteinase and related proteins in fibrogenic cells and keratinocytes .
8174772	0	bone_morphogenetic_protein-1	30,58	tolloid	121,128	bone morphogenetic protein-1	tolloid	12153(Tax:10090)	42945(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Embryonic expression of mouse bone_morphogenetic_protein-1 -LRB- BMP-1 -RRB- , which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase .
23645739	0	bone_morphogenetic_protein-10	14,43	BMP10	45,50	bone morphogenetic protein-10	BMP10	27302	27302	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of bone_morphogenetic_protein-10 -LRB- BMP10 -RRB- in human urothelial_cancer_of_the_bladder and its effects on the aggressiveness of bladder_cancer cells in vitro .
15136966	0	bone_morphogenetic_protein-15	81,110	BMP15	112,117	bone morphogenetic protein-15	BMP15	9210	9210	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Hypergonadotropic_ovarian_failure associated with an inherited mutation of human bone_morphogenetic_protein-15 -LRB- BMP15 -RRB- gene .
15385883	0	bone_morphogenetic_protein-2	10,38	BMP-2	40,45	bone morphogenetic protein-2	BMP-2	29373(Tax:10116)	29373(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- on matrix production , other BMPs , and BMP receptors in rat intervertebral disc cells .
8018727	0	bone_morphogenetic_protein-2	32,60	BMP-2	67,72	bone morphogenetic protein-2	BMP-2	12156(Tax:10090)	12156(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and sequence of mouse bone_morphogenetic_protein-2 gene -LRB- BMP-2 -RRB- : comparison of the structures and promoter regions of BMP-2 and BMP-4 genes .
21729805	0	bone_morphogenetic_protein-2	98,126	Bone_morphogenetic_protein-binding_peptide	0,42	bone morphogenetic protein-2	Bone morphogenetic protein-binding peptide	650	25907	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Bone_morphogenetic_protein-binding_peptide reduces the inflammatory response to recombinant human bone_morphogenetic_protein-2 and recombinant human bone_morphogenetic_protein-7 in a rodent model of soft-tissue inflammation .
11741887	0	bone_morphogenetic_protein-2	45,73	Matrix_GLA_protein	0,18	bone morphogenetic protein-2	Matrix GLA protein	650	4256	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Matrix_GLA_protein , a regulatory protein for bone_morphogenetic_protein-2 .
18495116	0	bone_morphogenetic_protein-2	17,45	PI3K	61,65	bone morphogenetic protein-2	PI3K	650	5295	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Naringin-induced bone_morphogenetic_protein-2 expression via PI3K , Akt , c-Fos/c-Jun and AP-1 pathway in osteoblasts .
16328004	0	bone_morphogenetic_protein-2	23,51	RANKL	0,5	bone morphogenetic protein-2	RANKL	12156(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	RANKL directly induces bone_morphogenetic_protein-2 expression in RANK-expressing POS-1 osteosarcoma cells .
21163272	0	bone_morphogenetic_protein-2	61,89	Runx2	114,119	bone morphogenetic protein-2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	p38|amod|START_ENTITY accelerates|nmod|p38 accelerates|advcl|activate activate|dobj|transcription transcription|amod|END_ENTITY	8-Prenylkaempferol accelerates osteoblast maturation through bone_morphogenetic_protein-2 / p38 pathway to activate Runx2 transcription .
25625570	0	bone_morphogenetic_protein-2	78,106	Runx2	127,132	bone morphogenetic protein-2	Runx2	12156(Tax:10090)	12393(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Radix_Dipsaci_total_saponins stimulate MC3T3-E1 cell differentiation via the bone_morphogenetic_protein-2 / MAPK/Smad-dependent Runx2 pathway .
21325271	0	bone_morphogenetic_protein-2	41,69	Toll-like_receptors_2_and_4	111,138	bone morphogenetic protein-2	Toll-like receptors 2 and 4	650	7097;7099	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Oxidized low density lipoprotein induces bone_morphogenetic_protein-2 in coronary artery endothelial cells via Toll-like_receptors_2_and_4 .
23341458	0	bone_morphogenetic_protein-2	67,95	factor_VII-activating_protease	4,34	bone morphogenetic protein-2	factor VII-activating protease	650	3026	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	The factor_VII-activating_protease -LRB- FSAP -RRB- enhances the activity of bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- .
12221014	0	bone_morphogenetic_protein-2	93,121	fibroblast_growth_factor-2	14,40	bone morphogenetic protein-2	fibroblast growth factor-2	650	2247	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	The effect of fibroblast_growth_factor-2 on the osteoinductive activity of recombinant human bone_morphogenetic_protein-2 in rat muscle .
22799302	0	bone_morphogenetic_protein-2	42,70	insulin-like_growth_factor-1	10,38	bone morphogenetic protein-2	insulin-like growth factor-1	650	3479	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of insulin-like_growth_factor-1 on bone_morphogenetic_protein-2 expression in hepatic_carcinoma SMMC7721 cells through the p38 MAPK signaling pathway .
18667779	0	bone_morphogenetic_protein-2	11,39	membrane_Type_1-matrix_metalloproteinase	61,101	bone morphogenetic protein-2	membrane Type 1-matrix metalloproteinase	650	4323	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of bone_morphogenetic_protein-2 on the expression of membrane_Type_1-matrix_metalloproteinase in human A549 lung_carcinoma cells -RSB- .
11780235	0	bone_morphogenetic_protein-2	29,57	osteopontin	79,90	bone morphogenetic protein-2	osteopontin	650	6696	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of recombinant human bone_morphogenetic_protein-2 on the expression of osteopontin in human periodontal ligament cells -RSB- .
15956019	0	bone_morphogenetic_protein-2	46,74	p38	75,78	bone morphogenetic protein-2	p38	650	5594	Gene	Gene	differentiation|dep|START_ENTITY differentiation|parataxis|END_ENTITY	Osthole-mediated cell differentiation through bone_morphogenetic_protein-2 / p38 and extracellular_signal-regulated_kinase_1 / 2 pathway in human osteoblast cells .
17113042	0	bone_morphogenetic_protein-2	59,87	p38	88,91	bone morphogenetic protein-2	p38	650	1432	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Myricetin induces human osteoblast differentiation through bone_morphogenetic_protein-2 / p38 mitogen-activated protein kinase pathway .
17980360	0	bone_morphogenetic_protein-2	15,43	p38	102,105	bone morphogenetic protein-2	p38	29373(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Enhancement|nmod|expression Enhancement|nmod|pathway pathway|amod|END_ENTITY	Enhancement of bone_morphogenetic_protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts .
22799302	0	bone_morphogenetic_protein-2	42,70	p38	130,133	bone morphogenetic protein-2	p38	650	1432	Gene	Gene	expression|amod|START_ENTITY insulin-like_growth_factor-1|nmod|expression cells|amod|insulin-like_growth_factor-1 cells|nmod|MAPK MAPK|amod|END_ENTITY	Effect of insulin-like_growth_factor-1 on bone_morphogenetic_protein-2 expression in hepatic_carcinoma SMMC7721 cells through the p38 MAPK signaling pathway .
15851600	0	bone_morphogenetic_protein-2	14,42	tumor_necrosis_factor-alpha	120,147	bone morphogenetic protein-2	tumor necrosis factor-alpha	650	7124	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|activation activation|nmod|END_ENTITY	Regulation of bone_morphogenetic_protein-2 expression in endothelial cells : role of nuclear factor-kappaB activation by tumor_necrosis_factor-alpha , H2O2 , and high intravascular pressure .
16835229	0	bone_morphogenetic_protein-2	62,90	tumor_necrosis_factor-alpha	26,53	bone morphogenetic protein-2	tumor necrosis factor-alpha	650	7124	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Pro-inflammatory cytokine tumor_necrosis_factor-alpha induces bone_morphogenetic_protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation .
22041018	0	bone_morphogenetic_protein-2	12,40	vascular_endothelial_growth_factor	66,100	bone morphogenetic protein-2	vascular endothelial growth factor	650	7422	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Recombinant bone_morphogenetic_protein-2 induces up-regulation of vascular_endothelial_growth_factor and interleukin_6 in human pre-osteoblasts : role of reactive oxygen species .
9929985	0	bone_morphogenetic_protein-4	46,74	BMP_4	76,81	bone morphogenetic protein-4	BMP 4	652	652	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A single-nucleotide polymorphism in the human bone_morphogenetic_protein-4 -LRB- BMP_4 -RRB- gene .
12445813	0	bone_morphogenetic_protein-4	29,57	ST2	119,122	bone morphogenetic protein-4	ST2	12159(Tax:10090)	17082(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Phosphate depletion enhances bone_morphogenetic_protein-4 gene expression in a cultured mouse marrow stromal cell line ST2 .
18006160	0	bone_morphogenetic_protein-4	42,70	Smad1/4	12,19	bone morphogenetic protein-4	Smad1/4	652	4086;4089	Gene	Gene	activation|amod|START_ENTITY signaling|nmod|activation END_ENTITY|acl|signaling	Visualizing Smad1/4 signaling response to bone_morphogenetic_protein-4 activation by FRET biosensors .
23311397	0	bone_morphogenetic_protein-4	10,38	Sox2	60,64	bone morphogenetic protein-4	Sox2	652	6657	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of bone_morphogenetic_protein-4 on the expression of Sox2 , Oct-4 , and c-Myc in human periodontal ligament cells during long-term culture .
19661459	0	bone_morphogenetic_protein-4	40,68	matrix_Gla_protein	90,108	bone morphogenetic protein-4	matrix Gla protein	12159(Tax:10090)	17313(Tax:10090)	Gene	Gene	signaling|dep|START_ENTITY signaling|nmod|END_ENTITY	Heat_shock protein 70 enhances vascular bone_morphogenetic_protein-4 signaling by binding matrix_Gla_protein .
11255225	0	bone_morphogenetic_protein-4	118,146	vascular_endothelial_growth_factor	70,104	bone morphogenetic protein-4	vascular endothelial growth factor	12159(Tax:10090)	22339(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Involvement of p70 S6 kinase in bone morphogenetic protein signaling : vascular_endothelial_growth_factor synthesis by bone_morphogenetic_protein-4 in osteoblasts .
21319131	0	bone_morphogenetic_protein-5	12,40	BMP-5	42,47	bone morphogenetic protein-5	BMP-5	653	653	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of bone_morphogenetic_protein-5 -LRB- BMP-5 -RRB- in human nephrosclerosis .
11732805	0	bone_morphogenetic_protein-6	14,42	BMP-6	44,49	bone morphogenetic protein-6	BMP-6	654	654	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of bone_morphogenetic_protein-6 -LRB- BMP-6 -RRB- in myoepithelial cells in canine mammary gland_tumors .
7707865	0	bone_morphogenetic_protein-6	59,87	BMP-6	89,94	bone morphogenetic protein-6	BMP-6	25644(Tax:10116)	25644(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Developmental alteration and neuron-specific expression of bone_morphogenetic_protein-6 -LRB- BMP-6 -RRB- mRNA in rodent brain .
20889504	0	bone_morphogenetic_protein-6	41,69	interleukin-6	13,26	bone morphogenetic protein-6	interleukin-6	654	3569	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin-6 expression by bone_morphogenetic_protein-6 in macrophages requires both SMAD and p38 signaling pathways .
11846481	0	bone_morphogenetic_protein-7	22,50	BMP-7	52,57	bone morphogenetic protein-7	BMP-7	395494(Tax:9031)	395494(Tax:9031)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Follistatin regulates bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- activity to stimulate embryonic muscle growth .
14991870	0	bone_morphogenetic_protein-7	14,42	BMP-7	44,49	bone morphogenetic protein-7	BMP-7	655	655	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- in human prostate .
15293217	0	bone_morphogenetic_protein-7	11,39	BMP-7	41,46	bone morphogenetic protein-7	BMP-7	12162(Tax:10090)	12162(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- on primordial follicular growth in the mouse ovary .
11846481	0	bone_morphogenetic_protein-7	22,50	Follistatin	0,11	bone morphogenetic protein-7	Follistatin	395494(Tax:9031)	396119(Tax:9031)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Follistatin regulates bone_morphogenetic_protein-7 -LRB- BMP-7 -RRB- activity to stimulate embryonic muscle growth .
26617798	0	bone_morphogenetic_protein-7	63,91	MicroRNA-137	0,12	bone morphogenetic protein-7	MicroRNA-137	655	406928	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-137 inhibits cell migration and invasion by targeting bone_morphogenetic_protein-7 -LRB- BMP7 -RRB- in non-small_cell_lung_cancer cells .
12472235	0	bone_morphogenetic_protein-7	54,82	osteogenic_protein-1	32,52	bone morphogenetic protein-7	osteogenic protein-1	655	655	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	The effect of recombinant human osteogenic_protein-1 -LRB- bone_morphogenetic_protein-7 -RRB- impregnation on allografts in a canine intercalary bone defect .
7560881	0	bone_morphogenetic_protein-7	44,72	osteogenic_protein-1	22,42	bone morphogenetic protein-7	osteogenic protein-1	655	655	Gene	Gene	pattern|dep|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of osteogenic_protein-1 -LRB- bone_morphogenetic_protein-7 -RRB- in human and mouse development .
15629804	0	bone_morphogenetic_protein2	14,41	BMP2	119,123	bone morphogenetic protein2	BMP2	615037(Tax:9913)	615037(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of bone_morphogenetic_protein2 -LRB- BMP2 -RRB- , BMP4 and BMP receptors in the bovine ovary but absence of effects of BMP2 and BMP4 during IVM on bovine oocyte nuclear maturation and subsequent embryo development .
8404039	0	bone_morphogenetic_protein_1	15,43	BMP1	50,54	bone morphogenetic protein 1	BMP1	649	649	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the bone_morphogenetic_protein_1 gene -LRB- BMP1 -RRB- to 8p21 : removal of BMP1 from candidacy for the bone_disorder in Langer-Giedion_syndrome .
17071617	0	bone_morphogenetic_protein_1	14,42	alpha2-macroglobulin	74,94	bone morphogenetic protein 1	alpha2-macroglobulin	649	2	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of bone_morphogenetic_protein_1 by native and altered forms of alpha2-macroglobulin .
1840509	0	bone_morphogenetic_protein_1	74,102	tolloid	46,53	bone morphogenetic protein 1	tolloid	649	42945(Tax:7227)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	The Drosophila dorsal-ventral patterning gene tolloid is related to human bone_morphogenetic_protein_1 .
19433911	0	bone_morphogenetic_protein_15	56,85	BMP15	92,97	bone morphogenetic protein 15	BMP15	353351(Tax:9913)	353351(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detecting a deletion in the coding region of the bovine bone_morphogenetic_protein_15 gene -LRB- BMP15 -RRB- .
21970812	0	bone_morphogenetic_protein_15	46,75	growth_differentiation_factor_9	13,44	bone morphogenetic protein 15	growth differentiation factor 9	353351(Tax:9913)	282574(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	The ratio of growth_differentiation_factor_9 : bone_morphogenetic_protein_15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates .
21622876	0	bone_morphogenetic_protein_15	42,71	ovulation_rate	129,143	bone morphogenetic protein 15	ovulation rate	100052461(Tax:9796)	100689616	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Effect of the FecX -LRB- R -RRB- polymorphism in the bone_morphogenetic_protein_15 gene on natural or equine chorionic gonadotropin-induced ovulation_rate and litter size in Rasa Aragonesa ewes and implications for on-farm application .
11882013	0	bone_morphogenetic_protein_2	10,38	BMP2	40,44	bone morphogenetic protein 2	BMP2	443173(Tax:9940)	443173(Tax:9940)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of bone_morphogenetic_protein_2 -LRB- BMP2 -RRB- on oestradiol and inhibin_A production by sheep granulosa cells , and localization of BMP receptors in the ovary by immunohistochemistry .
16432645	0	bone_morphogenetic_protein_2	21,49	BMP2	51,55	bone morphogenetic protein 2	BMP2	650	650	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the bone_morphogenetic_protein_2 -LRB- BMP2 -RRB- gene do not affect bone_mineral_density in white men or women .
19103752	0	bone_morphogenetic_protein_2	61,89	Gli2	149,153	bone morphogenetic protein 2	Gli2	12156(Tax:10090)	14633(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of microtubule assembly in osteoblasts stimulates bone_morphogenetic_protein_2 expression and bone formation through transcription factor Gli2 .
12960089	0	bone_morphogenetic_protein_2	51,79	Parathyroid_hormone-related_peptide	0,35	bone morphogenetic protein 2	Parathyroid hormone-related peptide	12156(Tax:10090)	19227(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Parathyroid_hormone-related_peptide interacts with bone_morphogenetic_protein_2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells .
12933820	0	bone_morphogenetic_protein_2	6,34	Runx2	176,181	bone morphogenetic protein 2	Runx2	650	860	Gene	Gene	treatment|amod|START_ENTITY rescues|nsubj|treatment rescues|nmod|alteration alteration|nmod|END_ENTITY	Brief bone_morphogenetic_protein_2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx2 .
19754224	0	bone_morphogenetic_protein_2	44,72	Vascular_endothelial_growth_factor	0,34	bone morphogenetic protein 2	Vascular endothelial growth factor	29373(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Vascular_endothelial_growth_factor inhibits bone_morphogenetic_protein_2 expression in rat mesenchymal stem cells .
12162497	0	bone_morphogenetic_protein_2	115,143	cyclo-oxygenase_2	37,54	bone morphogenetic protein 2	cyclo-oxygenase 2	12156(Tax:10090)	19225(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY role|nmod|effects induces|dobj|role induces|xcomp|END_ENTITY	Bone_morphogenetic_protein_2 induces cyclo-oxygenase_2 in osteoblasts via a Cbfal binding site : role in effects of bone_morphogenetic_protein_2 in vitro and in vivo .
19646521	0	bone_morphogenetic_protein_2	93,121	leukemia_inhibitory_factor	46,72	bone morphogenetic protein 2	leukemia inhibitory factor	12156(Tax:10090)	16878(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Retinal astrocyte differentiation mediated by leukemia_inhibitory_factor in cooperation with bone_morphogenetic_protein_2 .
9817598	0	bone_morphogenetic_protein_2	135,163	rHOX	33,37	bone morphogenetic protein 2	rHOX	12156(Tax:10090)	266813(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	Expression of rat homeobox gene , rHOX , in developing and adult tissues in mice and regulation of its mRNA expression in osteoblasts by bone_morphogenetic_protein_2 and parathyroid hormone-related protein .
26071314	0	bone_morphogenetic_protein_2	89,117	sclerostin	26,36	bone morphogenetic protein 2	sclerostin	650	50964	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	DNA methylation regulates sclerostin -LRB- SOST -RRB- expression in osteoarthritic chondrocytes by bone_morphogenetic_protein_2 -LRB- BMP-2 -RRB- induced changes in Smads binding affinity to the CpG region of SOST promoter .
9701626	0	bone_morphogenetic_protein_4	10,38	BMP-4	40,45	bone morphogenetic protein 4	BMP-4	652	652	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human bone_morphogenetic_protein_4 -LRB- BMP-4 -RRB- gene : molecular structure and transcriptional regulation .
25085606	0	bone_morphogenetic_protein_4	11,39	BMP4	41,45	bone morphogenetic protein 4	BMP4	443502(Tax:9940)	443502(Tax:9940)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of bone_morphogenetic_protein_4 -LRB- BMP4 -RRB- supplementation during culture of the sheep ovarian cortex .
26970275	0	bone_morphogenetic_protein_4	14,42	BMP4	44,48	bone morphogenetic protein 4	BMP4	12159(Tax:10090)	12159(Tax:10090)	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	The impact of bone_morphogenetic_protein_4 -LRB- BMP4 -RRB- on breast_cancer metastasis in a mouse xenograft model .
20079000	0	bone_morphogenetic_protein_4	79,107	basic_fibroblast_growth_factor	11,41	bone morphogenetic protein 4	basic fibroblast growth factor	25296(Tax:10116)	54250(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of basic_fibroblast_growth_factor on expression of protein and mRNA of bone_morphogenetic_protein_4 in hypoxic-ischemic_brain_damage in newborn rats -RSB- .
8752214	0	bone_morphogenetic_protein_4	58,86	noggin	29,35	bone morphogenetic protein 4	noggin	652	9241	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The Spemann organizer signal noggin binds and inactivates bone_morphogenetic_protein_4 .
22476375	0	bone_morphogenetic_protein_7	36,64	BMP-7	66,71	bone morphogenetic protein 7	BMP-7	655	655	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Results of nonunion treatment with bone_morphogenetic_protein_7 -LRB- BMP-7 -RRB- -RSB- .
24035155	0	bone_morphogenetic_protein_7	21,49	BMP7	56,60	bone morphogenetic protein 7	BMP7	655	655	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the bone_morphogenetic_protein_7 gene -LRB- BMP7 -RRB- and association analysis with sow productive traits .
25237187	0	bone_morphogenetic_protein_9	14,42	BMP9	44,48	bone morphogenetic protein 9	BMP9	2658	2658	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of bone_morphogenetic_protein_9 -LRB- BMP9 -RRB- by redox-dependent proteolysis .
22474252	0	bone_morphogenetic_protein_9	26,54	Crossveinless_2	0,15	bone morphogenetic protein 9	Crossveinless 2	2658	168667	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Crossveinless_2 regulates bone_morphogenetic_protein_9 in human and mouse vascular endothelium .
25854560	0	bone_morphogenetic_protein_9	21,49	Wnt3a	1,6	bone morphogenetic protein 9	Wnt3a	12165(Tax:10090)	22416(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	-LSB- Wnt3a combined with bone_morphogenetic_protein_9 induce C3H10T1/2 cells differentiation into cardiomyocyte-like cells in vitro -RSB- .
23639540	0	bone_morphogenetic_protein_receptor	72,107	BMP	109,112	bone morphogenetic protein receptor	BMP	649	649	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Synthesis and structure-activity relationships of a novel and selective bone_morphogenetic_protein_receptor -LRB- BMP -RRB- inhibitor derived from the pyrazolo -LSB- 1.5-a -RSB- pyrimidine scaffold of dorsomorphin : the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe .
16155937	0	bone_morphogenetic_protein_type_II_receptor	75,118	stem_cell_factor	144,160	bone morphogenetic protein type II receptor	stem cell factor	12168(Tax:10090)	17311(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Interaction and functional cooperation between the serine/threonine kinase bone_morphogenetic_protein_type_II_receptor with the tyrosine kinase stem_cell_factor receptor .
11312159	0	bone_morphogenetic_receptor_type_1_B	67,103	BMPR1B	105,111	bone morphogenetic receptor type 1 B	BMPR1B	443454(Tax:9940)	443454(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Booroola -LRB- FecB -RRB- phenotype is associated with a mutation in the bone_morphogenetic_receptor_type_1_B -LRB- BMPR1B -RRB- gene .
17900349	0	bone_morphogenic_protein	135,159	transforming_growth_factor-beta	103,134	bone morphogenic protein	transforming growth factor-beta	649	7040	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling , WNT and transforming_growth_factor-beta / bone_morphogenic_protein signalling .
23877969	0	bone_morphogenic_protein-15	86,113	BMP15	115,120	bone morphogenic protein-15	BMP15	9210	9210	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Anti-M llerian hormone -LRB- AMH -RRB- , inhibin-a , growth_differentiation_factor_9 -LRB- GDF9 -RRB- , and bone_morphogenic_protein-15 -LRB- BMP15 -RRB- mRNA and protein are influenced by photoperiod-induced ovarian regression and recrudescence in Siberian hamster ovaries .
11600747	0	bone_morphogenic_protein-2	15,41	BMP-2	43,48	bone morphogenic protein-2	BMP-2	650	650	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of bone_morphogenic_protein-2 -LRB- BMP-2 -RRB- in the pathological ossification process of_the_spinal_ligament .
23471555	0	bone_morphogenic_protein-7	28,54	BMP-7	55,60	bone morphogenic protein-7	BMP-7	85272(Tax:10116)	85272(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The anti-fibrotic effect of bone_morphogenic_protein-7 -LRB- BMP-7 -RRB- on liver_fibrosis .
12397613	0	bone_sialoprotein	21,38	BSP	40,43	bone sialoprotein	BSP	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TNF-alpha suppresses bone_sialoprotein -LRB- BSP -RRB- expression in ROS17/2 .8 cells .
12766167	0	bone_sialoprotein	28,45	BSP	47,50	bone sialoprotein	BSP	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prostaglandin_E2 stimulates bone_sialoprotein -LRB- BSP -RRB- expression through cAMP and fibroblast_growth_factor_2 response elements in the proximal promoter of the rat BSP gene .
16171436	0	bone_sialoprotein	22,39	BSP	41,44	bone sialoprotein	BSP	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Amelogenin stimulates bone_sialoprotein -LRB- BSP -RRB- expression through fibroblast_growth_factor_2 response element and transforming_growth_factor-beta1 activation element in the promoter of the BSP gene .
16187297	0	bone_sialoprotein	14,31	BSP	33,36	bone sialoprotein	BSP	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of bone_sialoprotein -LRB- BSP -RRB- gene transcription by lipopolysaccharide .
16642470	0	bone_sialoprotein	39,56	BSP	58,61	bone sialoprotein	BSP	3381	3381	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Insulin-like_growth_factor-I increases bone_sialoprotein -LRB- BSP -RRB- expression through fibroblast_growth_factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene .
2072878	0	bone_sialoprotein	16,33	BSP	35,38	bone sialoprotein	BSP	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of bone_sialoprotein -LRB- BSP -RRB- expression to sites of mineralized tissue formation in fetal rat tissues by in situ hybridization .
7601099	0	bone_sialoprotein	29,46	BSP	48,51	bone sialoprotein	BSP	24477(Tax:10116)	24477(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Glucocorticoid regulation of bone_sialoprotein -LRB- BSP -RRB- gene expression .
8419459	0	bone_sialoprotein	16,33	BSP	35,38	bone sialoprotein	BSP	24477(Tax:10116)	3381	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of bone_sialoprotein -LRB- BSP -RRB- to Golgi and post-Golgi secretory structures in osteoblasts and to discrete sites in early bone matrix .
9084640	0	bone_sialoprotein	24,41	BSP	43,46	bone sialoprotein	BSP	3381	3381	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the bone_sialoprotein -LRB- BSP -RRB- gene promoter .
20587945	0	bone_sialoprotein	27,44	Endothelin-1	0,12	bone sialoprotein	Endothelin-1	24477(Tax:10116)	24323(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Endothelin-1 regulates rat bone_sialoprotein gene transcription .
10747989	0	bone_sialoprotein	20,37	Factor_H	0,8	bone sialoprotein	Factor H	3381	3075	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Factor_H binding to bone_sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack .
16466682	0	bone_sialoprotein	67,84	Fibroblast_growth_factor_2	0,26	bone sialoprotein	Fibroblast growth factor 2	3381	2247	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Fibroblast_growth_factor_2 and cyclic_AMP synergistically regulate bone_sialoprotein gene expression .
26973342	0	bone_sialoprotein	27,44	GATA4	0,5	bone sialoprotein	GATA4	3381	2626	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GATA4 negatively regulates bone_sialoprotein expression in osteoblasts .
16642470	0	bone_sialoprotein	39,56	Insulin-like_growth_factor-I	0,28	bone sialoprotein	Insulin-like growth factor-I	3381	3479	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Insulin-like_growth_factor-I increases bone_sialoprotein -LRB- BSP -RRB- expression through fibroblast_growth_factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene .
23485603	0	bone_sialoprotein	40,57	fibroblast_growth_factor_2	66,92	bone sialoprotein	fibroblast growth factor 2	3381	2247	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the human bone_sialoprotein gene by fibroblast_growth_factor_2 .
21276840	0	bone_sialoprotein	30,47	interleukin-11	56,70	bone sialoprotein	interleukin-11	24477(Tax:10116)	171040(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of bone_sialoprotein gene by interleukin-11 .
8109457	0	bovine_corneal_protein_54K	17,43	BCP_54	45,51	bovine corneal protein 54K	BCP 54	281617(Tax:9913)	281617(Tax:9913)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	-LSB- Localization of bovine_corneal_protein_54K -LRB- BCP_54 -RRB- in the prenatal mouse eye -RSB- .
8176381	0	bovine_viral_diarrhoea_virus	13,41	p80	42,45	bovine viral diarrhoea virus	p80	105754165	505638(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Detection of bovine_viral_diarrhoea_virus p80 protein in subpopulations of bovine leukocytes .
12835381	0	bozozok	0,7	bmp2b	27,32	bozozok	bmp2b	30170(Tax:7955)	30632(Tax:7955)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish .
8835524	0	brachymorphic	33,46	bm	48,50	brachymorphic	bm	23972(Tax:10090)	23972(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular markers near the mouse brachymorphic -LRB- bm -RRB- gene , which affects connective tissues and bleeding time .
12103271	0	bradykinin	162,172	Angiotensin-converting_enzyme	0,29	bradykinin	Angiotensin-converting enzyme	478666(Tax:9615)	610668(Tax:9615)	Gene	Gene	role|nmod|START_ENTITY flow|dep|role increase|dobj|flow increase|nsubj|inhibitors inhibitors|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitors and angiotensin_II_receptor_blockers synergistically increase coronary blood flow in canine ischemic myocardium : role of bradykinin .
12235256	0	bradykinin	122,132	Angiotensin-converting_enzyme	0,29	bradykinin	Angiotensin-converting enzyme	3827	1636	Gene	Gene	des-arginine|dep|START_ENTITY degradation|nmod|des-arginine characterized|nmod|degradation characterized|nsubjpass|angioedema angioedema|amod|END_ENTITY	Angiotensin-converting_enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine -LRB- 9 -RRB- - bradykinin .
12566370	0	bradykinin	127,137	Angiotensin-converting_enzyme	0,29	bradykinin	Angiotensin-converting enzyme	3827	1636	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|inhibition inhibition|amod|END_ENTITY	Angiotensin-converting_enzyme inhibition increases human vascular tissue-type_plasminogen_activator release through endogenous bradykinin .
15055254	0	bradykinin	136,146	Angiotensin-converting_enzyme	0,29	bradykinin	Angiotensin-converting enzyme	3827	1636	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|polymorphism polymorphism|amod|END_ENTITY	Angiotensin-converting_enzyme insertion/deletion polymorphism modulates coronary release of tissue_plasminogen_activator in response to bradykinin .
16219810	0	bradykinin	40,50	Angiotensin-converting_enzyme	0,29	bradykinin	Angiotensin-converting enzyme	3827	1636	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin-converting_enzyme regulates bradykinin receptor gene expression .
9383175	0	bradykinin	84,94	Angiotensin_converting_enzyme	0,29	bradykinin	Angiotensin converting enzyme	3827	1636	Gene	Gene	effect|nmod|START_ENTITY unmasks|dobj|effect unmasks|nsubj|inhibition inhibition|amod|END_ENTITY	Angiotensin_converting_enzyme inhibition unmasks the sympathofacilitatory effect of bradykinin in human right atrium .
10082496	0	bradykinin	15,25	B2_receptor	53,64	bradykinin	B2 receptor	3827	624	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of bradykinin and resensitization of its B2_receptor .
10551272	0	bradykinin	58,68	B2_receptor	69,80	bradykinin	B2 receptor	3827	624	Gene	Gene	FR_190997|compound|START_ENTITY FR_190997|compound|END_ENTITY	Pharmacological characterisation of the first non-peptide bradykinin B2_receptor agonist FR_190997 : an in vitro study on human , rabbit and pig vascular B2_receptors .
11311137	0	bradykinin	38,48	B2_receptor	115,126	bradykinin	B2 receptor	3827	624	Gene	Gene	receptors|compound|START_ENTITY trafficking|nmod|receptors trafficking|dep|sequestration sequestration|nmod|END_ENTITY	Agonist-promoted trafficking of human bradykinin receptors : arrestin - and dynamin-independent sequestration of the B2_receptor and bradykinin in HEK293 cells .
11517947	0	bradykinin	21,31	B2_receptor	32,43	bradykinin	B2 receptor	3827	624	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the bradykinin B2_receptor gene and childhood asthma .
12574004	0	bradykinin	139,149	B2_receptor	43,54	bradykinin	B2 receptor	3827	624	Gene	Gene	not|nmod|START_ENTITY increase|dep|not increase|nsubj|Changes Changes|nmod|portion portion|nmod|END_ENTITY	Changes in amino-terminal portion of human B2_receptor selectively increase efficacy of synthetic ligand HOE_140 but not of cognate ligand bradykinin .
12705334	0	bradykinin	63,73	B2_receptor	74,85	bradykinin	B2 receptor	3827	624	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Rapid and reliable genotyping of the C181T polymorphism in the bradykinin B2_receptor gene .
20050188	0	bradykinin	26,36	B2_receptor	88,99	bradykinin	B2 receptor	3827	624	Gene	Gene	characterization|compound|START_ENTITY characterization|nmod|antagonism antagonism|amod|END_ENTITY	Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2_receptor antagonism in human synovial fibroblasts .
20050188	0	bradykinin	77,87	B2_receptor	88,99	bradykinin	B2 receptor	3827	624	Gene	Gene	antagonism|amod|START_ENTITY antagonism|amod|END_ENTITY	Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2_receptor antagonism in human synovial fibroblasts .
22970904	0	bradykinin	16,26	B2_receptor	27,38	bradykinin	B2 receptor	3827	624	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Icatibant , the bradykinin B2_receptor antagonist with target to the interconnected kinin systems .
2907489	0	bradykinin	22,32	B2_receptor	36,47	bradykinin	B2 receptor	3827	624	Gene	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	-LSB- Phe8 psi -LRB- CH2-NH -RRB- Arg9 -RSB- bradykinin , a B2_receptor selective agonist which is not broken down by either kininase_I or kininase_II .
8856140	0	bradykinin	80,90	B2_receptor	4,15	bradykinin	B2 receptor	3827	624	Gene	Gene	arachidonic_acid|nmod|START_ENTITY release|nmod|arachidonic_acid END_ENTITY|dep|release	The B2_receptor on cultured human decidua cells : release of arachidonic_acid by bradykinin .
8873604	0	bradykinin	24,34	B2_receptor	35,46	bradykinin	B2 receptor	3827	624	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Na + ions binding to the bradykinin B2_receptor suppress agonist-independent receptor activation .
8910316	0	bradykinin	36,46	B2_receptor	111,122	bradykinin	B2 receptor	3827	624	Gene	Gene	group|nmod|START_ENTITY bound|nsubjpass|group bound|dobj|amino_acids amino_acids|nmod|END_ENTITY	The N-terminal amino group of -LSB- Tyr8 -RSB- bradykinin is bound adjacent to analogous amino_acids of the human and rat B2_receptor .
8939910	0	bradykinin	18,28	B2_receptor	64,75	bradykinin	B2 receptor	3827	624	Gene	Gene	terminus|nmod|START_ENTITY terminus|advcl|adjacent adjacent|nsubj|END_ENTITY	The N terminus of bradykinin when bound to the human bradykinin B2_receptor is adjacent to extracellular Cys20 and Cys277 in the receptor .
8939910	0	bradykinin	53,63	B2_receptor	64,75	bradykinin	B2 receptor	3827	624	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|amod|bound	The N terminus of bradykinin when bound to the human bradykinin B2_receptor is adjacent to extracellular Cys20 and Cys277 in the receptor .
9119014	0	bradykinin	48,58	B2_receptor	100,111	bradykinin	B2 receptor	3827	624	Gene	Gene	interaction|nmod|START_ENTITY study|nmod|interaction mimic|nsubj|study mimic|nmod|END_ENTITY	An NMR study of the interaction of 15N-labelled bradykinin with an antibody mimic of the bradykinin B2_receptor .
9224807	0	bradykinin	20,30	B2_receptor	77,88	bradykinin	B2 receptor	3827	624	Gene	Gene	mimic|nmod|START_ENTITY mimic|nmod|properties properties|nmod|END_ENTITY	Nonpeptide mimic of bradykinin with long-acting properties at the bradykinin B2_receptor .
9600070	0	bradykinin	55,65	B2_receptor	66,77	bradykinin	B2 receptor	3827	624	Gene	Gene	association|compound|START_ENTITY association|compound|END_ENTITY	Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2_receptor association of phospholipase_C_gamma_1 in vascular endothelial cells .
9606729	0	bradykinin	53,63	B2_receptor	92,103	bradykinin	B2 receptor	3827	624	Gene	Gene	investigations|nmod|START_ENTITY mimic|nsubj|investigations mimic|nmod|END_ENTITY	NMR investigations of recombinant 15N/13C/2H-labeled bradykinin bound to a Fab mimic of the B2_receptor .
9614202	0	bradykinin	26,36	B2_receptor	37,48	bradykinin	B2 receptor	3827	624	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Interleukin-1beta induces bradykinin B2_receptor gene expression through a prostanoid cyclic_AMP-dependent pathway in human bronchial smooth muscle cells .
12225948	0	bradykinin	10,20	COX-2	58,63	bradykinin	COX-2	3827	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of bradykinin , TGF-beta1 , IL-1beta , and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells .
14517215	0	bradykinin	30,40	Cyclooxygenase-2	0,16	bradykinin	Cyclooxygenase-2	3827	5743	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic_AMP response element through a novel autocrine loop involving endogenous prostaglandin_E2 , E-prostanoid_2 -LRB- EP2 -RRB- , and EP4 receptors .
16143655	0	bradykinin	30,40	Cyclooxygenase-2	0,16	bradykinin	Cyclooxygenase-2	3827	5743	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Cyclooxygenase-2 induction by bradykinin in aortic vascular smooth muscle cells .
16920798	0	bradykinin	122,132	Erk1	71,75	bradykinin	Erk1	3827	5595	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	An internally controlled peripheral biomarker for Alzheimer 's _ disease : Erk1 and Erk2 responses to the inflammatory signal bradykinin .
9606729	0	bradykinin	53,63	Fab	75,78	bradykinin	Fab	3827	2187	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	NMR investigations of recombinant 15N/13C/2H-labeled bradykinin bound to a Fab mimic of the B2_receptor .
18621420	0	bradykinin	43,53	IL-6	19,23	bradykinin	IL-6	3827	3569	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|compound|END_ENTITY	Bradykinin-induced IL-6 expression through bradykinin B2 receptor , phospholipase C , protein kinase Cdelta and NF-kappaB pathway in human synovial fibroblasts .
20184800	0	bradykinin	19,29	IL-6	72,76	bradykinin	IL-6	3827	3569	Gene	Gene	Cross-talk|nmod|START_ENTITY Cross-talk|advcl|regulating regulating|dobj|production production|compound|END_ENTITY	Cross-talk between bradykinin and epidermal_growth_factor in regulating IL-6 production in human airway_smooth_muscle cells .
9614202	0	bradykinin	26,36	Interleukin-1beta	0,17	bradykinin	Interleukin-1beta	3827	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces bradykinin B2_receptor gene expression through a prostanoid cyclic_AMP-dependent pathway in human bronchial smooth muscle cells .
16272198	0	bradykinin	21,31	Kallikrein	0,10	bradykinin	Kallikrein	3827	9622	Gene	Gene	receptors|amod|START_ENTITY activates|dobj|receptors activates|nsubj|END_ENTITY	Kallikrein activates bradykinin B2 receptors in absence of kininogen .
9622017	0	bradykinin	57,67	Met1	45,49	bradykinin	Met1	3827	3004	Gene	Gene	activity|dep|START_ENTITY activity|nmod|END_ENTITY	Purification and cardiovascular activity of -LSB- Met1 , Met5 -RSB- - bradykinin from the plasma of a sturgeon -LRB- Acipenseriformes -RRB- .
10080484	0	bradykinin	149,159	angiotensin-converting_enzyme	87,116	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	role|nmod|START_ENTITY inhibition|dep|role inhibition|amod|END_ENTITY	Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting_enzyme inhibition : a potential role of bradykinin .
10191623	0	bradykinin	42,52	angiotensin-converting_enzyme	9,38	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	provocation|amod|START_ENTITY END_ENTITY|nmod|provocation	-LSB- Role of angiotensin-converting_enzyme on bradykinin nasal provocation : comparison of normal volunteers and allergic subjects -RSB- .
10547087	0	bradykinin	10,20	angiotensin-converting_enzyme	86,115	bradykinin	angiotensin-converting enzyme	478666(Tax:9615)	610668(Tax:9615)	Gene	Gene	levels|compound|START_ENTITY accompany|nsubj|levels accompany|nmod|inhibition inhibition|nmod|END_ENTITY	Increased bradykinin levels accompany the hemodynamic response to acute inhibition of angiotensin-converting_enzyme in dogs with heart_failure .
10604961	0	bradykinin	61,71	angiotensin-converting_enzyme	75,104	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	START_ENTITY|nmod|humans humans|amod|END_ENTITY	Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting_enzyme inhibitor-treated humans .
10749699	0	bradykinin	16,26	angiotensin-converting_enzyme	30,59	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of bradykinin by angiotensin-converting_enzyme and by carboxypeptidase N in human plasma .
1282628	0	bradykinin	106,116	angiotensin-converting_enzyme	13,42	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	roles|nmod|START_ENTITY Influence|dep|roles Influence|nmod|inhibition inhibition|amod|END_ENTITY	Influence of angiotensin-converting_enzyme inhibition on sympathetic neurotransmission : possible roles of bradykinin and prostaglandins .
1282634	0	bradykinin	112,122	angiotensin-converting_enzyme	62,91	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	generation|compound|START_ENTITY role|nmod|generation Heterogeneity|dep|role Heterogeneity|nmod|effects effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Heterogeneity of endothelium-dependent vasodilator effects of angiotensin-converting_enzyme inhibitors : role of bradykinin generation during ACE inhibition .
15492133	0	bradykinin	62,72	angiotensin-converting_enzyme	98,127	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	START_ENTITY|nmod|patients patients|acl|treated treated|nmod|inhibition inhibition|amod|END_ENTITY	Neutral endopeptidase inhibition augments vascular actions of bradykinin in patients treated with angiotensin-converting_enzyme inhibition .
1663586	0	bradykinin	20,30	angiotensin-converting_enzyme	86,115	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	responsible|nsubj|START_ENTITY responsible|nmod|increase increase|nmod|calcium calcium|acl|produced produced|nmod|inhibitors inhibitors|amod|END_ENTITY	Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting_enzyme inhibitors in human endothelial cells .
17460297	0	bradykinin	105,115	angiotensin-converting_enzyme	58,87	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	role|nmod|START_ENTITY Suppression|dep|role Suppression|nmod|choroidal_neovascularization choroidal_neovascularization|nmod|END_ENTITY	Suppression of choroidal_neovascularization by inhibiting angiotensin-converting_enzyme : minimal role of bradykinin .
21651905	0	bradykinin	115,125	angiotensin-converting_enzyme	12,41	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	endopeptidase|dep|START_ENTITY endopeptidase|amod|END_ENTITY	Endothelial angiotensin-converting_enzyme and neutral endopeptidase in isolated human umbilical vein : an effective bradykinin inactivation pathway .
2185292	0	bradykinin	154,164	angiotensin-converting_enzyme	28,57	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	Studies|acl|START_ENTITY Studies|nmod|mechanism mechanism|nmod|responses responses|amod|END_ENTITY	Studies of the mechanism of angiotensin-converting_enzyme -LRB- ACE -RRB- inhibitor-associated angioedema : the effect of an ACE inhibitor on cutaneous responses to bradykinin , codeine , and histamine .
4377109	0	bradykinin	14,24	angiotensin-converting_enzyme	54,83	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of bradykinin and its higher homologues by angiotensin-converting_enzyme .
8964127	0	bradykinin	91,101	angiotensin-converting_enzyme	20,49	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	relation|acl|START_ENTITY relation|nmod|polymorphism polymorphism|amod|END_ENTITY	No relation between angiotensin-converting_enzyme gene polymorphism and dermal response to bradykinin in healthy subjects .
9374762	0	bradykinin	75,85	angiotensin-converting_enzyme	16,45	bradykinin	angiotensin-converting enzyme	3827	1636	Gene	Gene	metabolism|nmod|START_ENTITY END_ENTITY|nmod|metabolism	Contribution of angiotensin-converting_enzyme to the cardiac metabolism of bradykinin : an interspecies study .
1318793	0	bradykinin	53,63	angiotensin_I_converting_enzyme	67,98	bradykinin	angiotensin I converting enzyme	3827	1636	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Potentiation of endothelium-dependent relaxations to bradykinin by angiotensin_I_converting_enzyme inhibitors in canine coronary artery involves both endothelium-derived relaxing and hyperpolarizing factors .
10821135	0	bradykinin	124,134	angiotensin_converting_enzyme	66,95	bradykinin	angiotensin converting enzyme	478666(Tax:9615)	610668(Tax:9615)	Gene	Gene	role|nmod|START_ENTITY mechanisms|dep|role mechanisms|nmod|cardioprotection cardioprotection|acl|afforded afforded|nmod|inhibitors inhibitors|nmod|END_ENTITY	Cellular mechanisms of cardioprotection afforded by inhibitors of angiotensin_converting_enzyme in ischemic hearts : role of bradykinin and nitric_oxide .
1480537	0	bradykinin	60,70	angiotensin_converting_enzyme	88,117	bradykinin	angiotensin converting enzyme	3827	1636	Gene	Gene	intradermal|dobj|START_ENTITY intradermal|nmod|inhibitor inhibitor|compound|END_ENTITY	Absence of potentiation of the skin response to intradermal bradykinin by a long-acting angiotensin_converting_enzyme inhibitor , trandolapril , at conventional antihypertensive dosage in human volunteers : a double-blind , randomized , cross-over , placebo-controlled trial .
2541753	0	bradykinin	27,37	angiotensin_converting_enzyme	57,86	bradykinin	angiotensin converting enzyme	3827	1636	Gene	Gene	effects|nmod|START_ENTITY potentiated|nsubjpass|effects potentiated|nmod|inhibitors inhibitors|amod|END_ENTITY	The effects of intradermal bradykinin are potentiated by angiotensin_converting_enzyme inhibitors in hypertensive patients .
3034372	0	bradykinin	23,33	angiotensin_converting_enzyme	54,83	bradykinin	angiotensin converting enzyme	3827	1636	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of intradermal bradykinin after inhibition of angiotensin_converting_enzyme .
8930174	0	bradykinin	116,126	angiotensin_converting_enzyme	24,53	bradykinin	angiotensin converting enzyme	3827	1636	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|effects effects|nmod|END_ENTITY	Differential effects of angiotensin_converting_enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin .
9469636	0	bradykinin	16,26	angiotensin_converting_enzyme	61,90	bradykinin	angiotensin converting enzyme	3827	1636	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|nmod|action action|nmod|inhibition inhibition|amod|END_ENTITY	Contribution of bradykinin to the cardioprotective action of angiotensin_converting_enzyme inhibition in hypertension and after myocardial_infarction .
20050188	0	bradykinin	26,36	bradykinin	77,87	bradykinin	bradykinin	3827	3827	Gene	Gene	characterization|compound|START_ENTITY characterization|nmod|antagonism antagonism|amod|END_ENTITY	Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2_receptor antagonism in human synovial fibroblasts .
20050188	0	bradykinin	77,87	bradykinin	26,36	bradykinin	bradykinin	3827	3827	Gene	Gene	antagonism|amod|START_ENTITY characterization|nmod|antagonism characterization|compound|END_ENTITY	Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2_receptor antagonism in human synovial fibroblasts .
8227859	0	bradykinin	18,28	bradykinin	54,64	bradykinin	bradykinin	3827	3827	Gene	Gene	responses|nmod|START_ENTITY responses|dep|END_ENTITY	Skin responses to bradykinin , kallidin , and -LSB- desArg9 -RSB- - bradykinin in nonatopic and atopic volunteers .
8227859	0	bradykinin	54,64	bradykinin	18,28	bradykinin	bradykinin	3827	3827	Gene	Gene	responses|dep|START_ENTITY responses|nmod|END_ENTITY	Skin responses to bradykinin , kallidin , and -LSB- desArg9 -RSB- - bradykinin in nonatopic and atopic volunteers .
8680375	0	bradykinin	28,38	bradykinin	53,63	bradykinin	bradykinin	3827	3827	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Opposite effects of inhaled bradykinin and -LSB- desArg9 -RSB- - bradykinin on tracheobronchial clearance in normal humans .
8680375	0	bradykinin	53,63	bradykinin	28,38	bradykinin	bradykinin	3827	3827	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Opposite effects of inhaled bradykinin and -LSB- desArg9 -RSB- - bradykinin on tracheobronchial clearance in normal humans .
9435567	0	bradykinin	16,26	cyclooxygenase-2	79,95	bradykinin	cyclooxygenase-2	3827	5743	Gene	Gene	release|nmod|START_ENTITY release|dep|involvement involvement|nmod|induction induction|amod|END_ENTITY	PGE2 release by bradykinin in human airway smooth muscle cells : involvement of cyclooxygenase-2 induction .
3263965	0	bradykinin	156,166	epidermal_growth_factor	113,136	bradykinin	epidermal growth factor	3827	1950	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	An increase in intracellular free Ca2 + associated with serum-free growth stimulation of Swiss 3T3 fibroblasts by epidermal_growth_factor in the presence of bradykinin .
16394177	0	bradykinin	163,173	extracellular_signal-regulated_kinases_1_and_2	87,133	bradykinin	extracellular signal-regulated kinases 1 and 2	3827	5594	Gene	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated END_ENTITY|nmod|cells	Protein_kinase_C _ -LRB- PKC -RRB- - delta / - epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular_signal-regulated_kinases_1_and_2 in MCF-7 cells stimulated by bradykinin .
23803661	0	bradykinin	66,76	intercellular_adhesion_molecule-1	15,48	bradykinin	intercellular adhesion molecule-1	3827	3383	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Involvement of intercellular_adhesion_molecule-1 up-regulation in bradykinin promotes cell motility in human prostate_cancers .
10999954	0	bradykinin	6,16	kallikrein	47,57	bradykinin	kallikrein	3827	9622	Gene	Gene	B|compound|START_ENTITY _|nsubj|B _|ccomp|activated activated|nmod|proteases proteases|compound|END_ENTITY	Human bradykinin B -LRB- 2 -RRB- _ receptor is activated by kallikrein and other serine proteases .
4627469	0	bradykinin	31,41	kallikrein	45,55	bradykinin	kallikrein	3827	9622	Gene	Gene	release|nmod|START_ENTITY kinetics|nmod|release kinetics|nmod|END_ENTITY	The kinetics of the release of bradykinin by kallikrein in normal human plasma .
582675	0	bradykinin	42,52	kallikrein	23,33	bradykinin	kallikrein	3827	9622	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Antagonistic effect of kallikrein against bradykinin .
6566613	0	bradykinin	142,152	kallikrein	101,111	bradykinin	kallikrein	3827	9622	Gene	Gene	-RSB-|compound|START_ENTITY evaluation|nmod|-RSB- evaluation|nmod|END_ENTITY	-LSB- Comparative evaluation of the action of nonsteroidal anti-inflammatory preparations on blood plasma kallikrein and the biological effects of bradykinin -RSB- .
6308020	0	bradykinin	63,73	kininase_II	11,22	bradykinin	kininase II	3827	1636	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|Effects Effects|nmod|END_ENTITY	Effects of kininase_II inhibitors on the vasomotor response to bradykinin of feline intracranial and extracranial arteries in vitro and in situ .
6312406	0	bradykinin	84,94	kininase_II	14,25	bradykinin	kininase II	3827	1636	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nsubj|effect effect|nmod|END_ENTITY	The effect of kininase_II inhibitors on the response of feline cerebral arteries to bradykinin and angiotensin .
20299424	0	bradykinin	67,77	organic_anion_transporter_3	20,47	bradykinin	organic anion transporter 3	3827	9376	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human organic_anion_transporter_3 by peptide hormone bradykinin .
8753774	0	bradykinin	119,129	phospholipase_D	145,160	bradykinin	phospholipase D	3827	2822	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Activation of phospholipase_D in human fibroblasts by ceramide and sphingosine : evaluation of their modulatory role in bradykinin stimulation of phospholipase_D .
11755956	0	bradykinin	71,81	thrombin	33,41	bradykinin	thrombin	3827	2147	Gene	Gene	analogs|compound|START_ENTITY END_ENTITY|nmod|analogs	Developing peptide inhibitors to thrombin activation of platelets from bradykinin analogs .
15055254	0	bradykinin	136,146	tissue_plasminogen_activator	92,120	bradykinin	tissue plasminogen activator	3827	100128998	Gene	Gene	modulates|nmod|START_ENTITY modulates|dobj|release release|nmod|END_ENTITY	Angiotensin-converting_enzyme insertion/deletion polymorphism modulates coronary release of tissue_plasminogen_activator in response to bradykinin .
15705059	0	bradykinin_B1_receptor	63,85	BDKRB1	87,93	bradykinin B1 receptor	BDKRB1	623	623	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	In vivo DNase I-mediated footprinting analysis along the human bradykinin_B1_receptor -LRB- BDKRB1 -RRB- gene promoter : evidence for cell-specific regulation .
7834189	0	bradykinin_B1_receptor	56,78	interleukin-1_beta	82,100	bradykinin B1 receptor	interleukin-1 beta	100009198(Tax:9986)	100008990(Tax:9986)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Up-regulation of -LSB- 3H -RSB- - des-Arg10-kallidin binding to the bradykinin_B1_receptor by interleukin-1_beta in isolated smooth muscle cells : correlation with B1 agonist-induced PGI2 production .
10362533	0	bradykinin_B1_receptor	54,76	interleukin-1beta	14,31	bradykinin B1 receptor	interleukin-1beta	12061(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Regulation by interleukin-1beta of gene expression of bradykinin_B1_receptor in MH-S murine alveolar macrophage cell line .
9461531	0	bradykinin_B1_receptor	98,120	interleukin-1beta	10,27	bradykinin B1 receptor	interleukin-1beta	623	3553	Gene	Gene	expression|amod|START_ENTITY control|nmod|expression Roles|nmod|control Roles|nmod|END_ENTITY	Roles for interleukin-1beta , phorbol_ester and a post-transcriptional regulator in the control of bradykinin_B1_receptor gene expression .
26531356	0	brain-derived_neurotrophic_factor	46,79	5-HT1A_receptor	0,15	brain-derived neurotrophic factor	5-HT1A receptor	627	3350	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	5-HT1A_receptor gene in behavioral effects of brain-derived_neurotrophic_factor .
23892595	0	brain-derived_neurotrophic_factor	52,85	Apoptosis_signal-regulating_kinase_1	0,36	brain-derived neurotrophic factor	Apoptosis signal-regulating kinase 1	627	4217	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Apoptosis_signal-regulating_kinase_1 is involved in brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - enhanced cell motility and matrix_metalloproteinase_1 expression in human chondrosarcoma cells .
22404904	0	brain-derived_neurotrophic_factor	101,134	Arc	60,63	brain-derived neurotrophic factor	Arc	12064(Tax:10090)	11838(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|END_ENTITY	Induction of the plasticity-associated immediate early gene Arc by stress and hallucinogens : role of brain-derived_neurotrophic_factor .
11244490	0	brain-derived_neurotrophic_factor	28,61	BDNF	63,67	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel polymorphism of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene associated with late-onset Alzheimer 's _ disease .
11338187	0	brain-derived_neurotrophic_factor	19,52	BDNF	54,58	brain-derived neurotrophic factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dopamine regulates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in cultured embryonic mouse striatal cells .
11483252	0	brain-derived_neurotrophic_factor	21,54	BDNF	56,60	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Transient changes of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA expression in hippocampus during moderate ischemia induced by chronic bilateral common carotid artery occlusions in the rat .
12524161	0	brain-derived_neurotrophic_factor	25,58	BDNF	60,64	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene with bipolar_disorder .
12836135	0	brain-derived_neurotrophic_factor	25,58	BDNF	60,64	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence variants of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene are strongly associated with obsessive-compulsive_disorder .
12923891	0	brain-derived_neurotrophic_factor	15,48	BDNF	50,54	brain-derived neurotrophic factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the development of periodontal Ruffini endings .
14583394	0	brain-derived_neurotrophic_factor	6,39	BDNF	41,45	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in schizophrenia are indistinguishable from controls .
14730195	0	brain-derived_neurotrophic_factor	23,56	BDNF	58,62	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association study of a brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism and personality trait and intelligence in healthy young females .
14736076	0	brain-derived_neurotrophic_factor	14,47	BDNF	49,53	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression following antibiotic treatment of experimental bacterial_meningitis .
15053962	0	brain-derived_neurotrophic_factor	23,56	BDNF	58,62	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression analysis of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA isoforms after chronic and acute antidepressant treatment .
15274036	0	brain-derived_neurotrophic_factor	23,56	BDNF	58,62	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	association|amod|START_ENTITY association|appos|END_ENTITY	Non-replication of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- association in bipolar_affective_disorder : a Belgian patient-control study .
15659231	0	brain-derived_neurotrophic_factor	11,44	BDNF	46,50	brain-derived neurotrophic factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on glial cells and serotonergic neurones during development .
15791923	0	brain-derived_neurotrophic_factor	27,60	BDNF	62,66	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neuroprotective effects of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on hearing in experimental_pneumococcal_meningitis .
15837118	0	brain-derived_neurotrophic_factor	144,177	BDNF	179,183	brain-derived neurotrophic factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Social threat and novel cage stress-induced sustained extracellular-regulated kinase1/2 -LRB- ERK1/2 -RRB- phosphorylation but differential modulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in the hippocampus of NMRI mice .
15860348	0	brain-derived_neurotrophic_factor	4,37	BDNF	39,43	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Low brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity .
15905010	0	brain-derived_neurotrophic_factor	6,39	BDNF	41,45	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in patients with panic_disorder : as a biological predictor of response to group cognitive behavioral therapy .
15913870	0	brain-derived_neurotrophic_factor	22,55	BDNF	57,61	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene polymorphisms with panic_disorder .
15940292	0	brain-derived_neurotrophic_factor	107,140	BDNF	142,146	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene with susceptibility to ADHD .
15949651	0	brain-derived_neurotrophic_factor	22,55	BDNF	57,61	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene C-270T polymorphism with schizophrenia .
16043130	0	brain-derived_neurotrophic_factor	35,68	BDNF	70,74	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Val66Met coding variant of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene does not contribute toward variation in the personality trait neuroticism .
16054753	0	brain-derived_neurotrophic_factor	24,57	BDNF	59,63	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene 196_A / G polymorphism with Alzheimer 's _ disease -LRB- AD -RRB- in mainland Chinese .
16061712	0	brain-derived_neurotrophic_factor	14,47	BDNF	49,53	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- during sleep apnoea treatment .
16105728	0	brain-derived_neurotrophic_factor	46,79	BDNF	81,85	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between variations in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and temporal_lobe_epilepsy .
16139165	0	brain-derived_neurotrophic_factor	18,51	BDNF	53,57	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No implication of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene in unipolar_affective_disorder : evidence from Belgian first and replication patient-control studies .
16152572	0	brain-derived_neurotrophic_factor	69,102	BDNF	104,108	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Confirmation of association between the Val66Met polymorphism in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and bipolar_I_disorder .
16568151	0	brain-derived_neurotrophic_factor	36,69	BDNF	71,75	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A complex polymorphic region in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene confers susceptibility to bipolar_disorder and affects transcriptional activity .
16626638	0	brain-derived_neurotrophic_factor	39,72	BDNF	74,78	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Chronic stress induces upregulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and integrin alpha5 expression in the rat pineal gland .
16876769	0	brain-derived_neurotrophic_factor	33,66	BDNF	68,72	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Chronic corticosterone decreases brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and protein in the hippocampus , but not in the frontal cortex , of the rat .
17130481	0	brain-derived_neurotrophic_factor	127,160	BDNF	162,166	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hyperphagia , severe obesity , impaired_cognitive_function , and hyperactivity associated with functional loss of one copy of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
17267117	0	brain-derived_neurotrophic_factor	27,60	BDNF	62,66	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	No association between the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism and schizophrenia in Asian populations : Evidence from a case-control study and meta-analysis .
17344400	0	brain-derived_neurotrophic_factor	45,78	BDNF	80,84	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Oligomeric amyloid decreases basal levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells .
17349978	0	brain-derived_neurotrophic_factor	24,57	BDNF	59,63	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic analyses of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene in autism .
17427191	0	brain-derived_neurotrophic_factor	4,37	BDNF	39,43	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Low brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in serum of Huntington 's _ disease patients .
17459549	0	brain-derived_neurotrophic_factor	128,161	BDNF	163,167	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol -LRB- MHPG -RRB- levels , but did not alter plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in schizophrenic patients .
17628454	0	brain-derived_neurotrophic_factor	18,51	BDNF	53,57	brain-derived neurotrophic factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Acute role of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on the respiratory neural network activity in mice in vitro .
17825920	0	brain-derived_neurotrophic_factor	95,128	BDNF	130,134	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Acute prefrontal cortex transcranial magnetic stimulation in healthy volunteers : no effects on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- concentrations in serum .
17923424	0	brain-derived_neurotrophic_factor	99,132	BDNF	134,138	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Emergence of an egocentric cue guiding and allocentric inferring strategy that mirrors hippocampal brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression in the Morris water maze .
17928160	0	brain-derived_neurotrophic_factor	61,94	BDNF	96,100	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Neuroactive steroids modulate HPA_axis activity and cerebral brain-derived_neurotrophic_factor -LRB- BDNF -RRB- protein levels in adult male rats .
17950272	0	brain-derived_neurotrophic_factor	23,56	BDNF	58,62	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Temporal expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA in the rat hippocampus after treatment with selective and mixed monoaminergic antidepressants .
18160197	0	brain-derived_neurotrophic_factor	28,61	BDNF	156,160	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Stress at work alters serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and plasma 3-methoxy-4-hydroxyphenylglycol -LRB- MHPG -RRB- levels in healthy volunteers : BDNF and MHPG as possible biological markers of mental_stress ?
18160197	0	brain-derived_neurotrophic_factor	28,61	BDNF	63,67	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Stress at work alters serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and plasma 3-methoxy-4-hydroxyphenylglycol -LRB- MHPG -RRB- levels in healthy volunteers : BDNF and MHPG as possible biological markers of mental_stress ?
18348609	0	brain-derived_neurotrophic_factor	24,57	BDNF	59,63	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Possible involvement of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the innervation of dopaminergic neurons from the rat periventricular nucleus to the pars intermedia .
18457678	0	brain-derived_neurotrophic_factor	115,148	BDNF	150,154	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
18474368	0	brain-derived_neurotrophic_factor	13,46	BDNF	48,52	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on serotonin neurotransmission in the hippocampus of adult rodents .
18544182	0	brain-derived_neurotrophic_factor	96,129	BDNF	131,135	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single immobilization stress differentially alters the expression profile of transcripts of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and histone acetylation at its promoters in the rat hippocampus .
18807247	0	brain-derived_neurotrophic_factor	47,80	BDNF	82,86	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Preliminary evidence of cannabinoid effects on brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in humans .
18842305	0	brain-derived_neurotrophic_factor	13,46	BDNF	48,52	Brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variation in brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene is associated with symptoms of depression .
18845611	0	brain-derived_neurotrophic_factor	29,62	BDNF	69,73	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common polymorphism in the brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- modulates human cortical plasticity and the response to rTMS .
19088493	0	brain-derived_neurotrophic_factor	21,54	BDNF	61,65	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Meta-analysis of the brain-derived_neurotrophic_factor gene -LRB- BDNF -RRB- Val66Met polymorphism in anxiety_disorders and anxiety-related_personality traits .
19170664	0	brain-derived_neurotrophic_factor	29,62	BDNF	64,68	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between Val66Met brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene polymorphism and post-treatment relapse in alcohol_dependence .
19255578	0	brain-derived_neurotrophic_factor	32,65	BDNF	67,71	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Population genetic study of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
19337469	0	brain-derived_neurotrophic_factor	29,62	BDNF	64,68	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Continuous decrease in serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in a neuropsychiatric_syndrome of systemic_lupus_erythematosus patient with organic brain changes .
19622243	0	brain-derived_neurotrophic_factor	47,80	BDNF	82,86	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between leptin_receptor -LRB- LEPR -RRB- and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene variants and obesity : a case-control study .
20004415	0	brain-derived_neurotrophic_factor	127,160	BDNF	162,166	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
20172535	0	brain-derived_neurotrophic_factor	14,47	BDNF	49,53	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment .
20434315	0	brain-derived_neurotrophic_factor	55,88	BDNF	90,94	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Comparison of brain N-acetylaspartate levels and serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels between patients with first-episode schizophrenia_psychosis and healthy controls .
20482942	0	brain-derived_neurotrophic_factor	20,53	BDNF	55,59	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fine-mapping of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene supports an association of the Val66Met polymorphism with episodic memory .
20643185	0	brain-derived_neurotrophic_factor	42,75	BDNF	77,81	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Differential expression and regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA isoforms in androgen-sensitive motoneurons of the rat lumbar spinal cord .
20797911	0	brain-derived_neurotrophic_factor	15,48	BDNF	50,54	brain-derived neurotrophic factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in MP4-induced autoimmune encephalomyelitis .
20970479	0	brain-derived_neurotrophic_factor	96,129	BDNF	131,135	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Quadri-pulse stimulation -LRB- QPS -RRB- induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
21098877	0	brain-derived_neurotrophic_factor	22,55	BDNF	57,61	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Family-based study of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene polymorphism in alcohol_dependence .
21179660	0	brain-derived_neurotrophic_factor	17,50	BDNF	52,56	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- Blood levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in major depressive_disorder -RSB- .
21188516	0	brain-derived_neurotrophic_factor	54,87	BDNF	89,93	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Total and mitochondrial nitrosative stress , decreased brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and glutamate uptake , and evidence of endoplasmic reticulum stress in the hippocampus of vitamin_A-treated rats .
21684022	0	brain-derived_neurotrophic_factor	53,86	BDNF	88,92	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Physical therapy intervention -LRB- PTI -RRB- increases plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in non-frail and pre-frail elderly women .
21889574	0	brain-derived_neurotrophic_factor	62,95	BDNF	97,101	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis between the Val66Met polymorphism in the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene and treatment response to venlafaxine_XR in generalized_anxiety_disorder .
21912609	0	brain-derived_neurotrophic_factor	32,65	BDNF	67,71	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA methylation profiles of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene as a potent diagnostic biomarker in major depression .
22005283	0	brain-derived_neurotrophic_factor	47,80	BDNF	82,86	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The effect of the Mediterranean diet on plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels : the PREDIMED-NAVARRA randomized trial .
22085476	0	brain-derived_neurotrophic_factor	58,91	BDNF	93,97	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence of associations between bipolar_disorder and the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene .
22218230	0	brain-derived_neurotrophic_factor	59,92	BDNF	21,25	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of serum BDNF and val66met polymorphism of the brain-derived_neurotrophic_factor in a sample of first psychotic_episode patients .
22642961	0	brain-derived_neurotrophic_factor	12,45	BDNF	47,51	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The role of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene variants in antipsychotic response and antipsychotic-induced weight_gain .
22672085	0	brain-derived_neurotrophic_factor	32,65	BDNF	67,71	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Robust changes in expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma .
22810739	0	brain-derived_neurotrophic_factor	32,65	BDNF	67,71	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	-LSB- The prognostic significance of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- for phobic_anxiety_disorders , vegetative_and_cognitive_impairments during conservative treatment including adaptol of some functional and organic diseases of nervous system -RSB- .
22900512	0	brain-derived_neurotrophic_factor	15,48	BDNF	50,54	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|appos|END_ENTITY	Expressions of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in cerebrospinal fluid and plasma of children with meningitis and encephalitis/encephalopathy .
22965830	0	brain-derived_neurotrophic_factor	16,49	BDNF	51,55	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	No influence of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- polymorphisms on treatment response in a naturalistic sample of patients with major_depression .
23012486	0	brain-derived_neurotrophic_factor	31,64	BDNF	66,70	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression and localization of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA and protein in human submandibular gland .
23209335	0	brain-derived_neurotrophic_factor	23,56	BDNF	58,62	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of stress-related brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the rat submandibular gland .
23522997	0	brain-derived_neurotrophic_factor	77,110	BDNF	112,116	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Combined therapeutic effect of udenafil and adipose-derived stem cell -LRB- ADSC -RRB- / brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - membrane system in a rat model of cavernous_nerve_injury .
23570723	0	brain-derived_neurotrophic_factor	16,49	BDNF	51,55	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increased serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in patients with narcolepsy .
23812866	0	brain-derived_neurotrophic_factor	6,39	BDNF	41,45	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in attention_deficit-hyperactivity_disorder -LRB- ADHD -RRB- .
23838134	0	brain-derived_neurotrophic_factor	24,57	BDNF	59,63	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- are decreased in colorectal_cancer patients .
23844985	0	brain-derived_neurotrophic_factor	35,68	BDNF	70,74	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Decreased plasma concentrations of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in patients with functional hypothalamic amenorrhea .
24255678	0	brain-derived_neurotrophic_factor	24,57	BDNF	59,63	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	Biological influence of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on colon_cancer cells .
24346357	0	brain-derived_neurotrophic_factor	33,66	BDNF	68,72	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Histone deacetylase activity and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in a pharmacological model of mania .
24467931	0	brain-derived_neurotrophic_factor	145,178	BDNF	180,184	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Altered plasma glutathione levels in bipolar_disorder indicates higher oxidative stress ; a possible risk factor for illness onset despite normal brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
24621065	0	brain-derived_neurotrophic_factor	33,66	BDNF	68,72	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Zinc monotherapy increases serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels and decreases_depressive_symptoms in overweight or obese subjects : A double-blind , randomized , placebo-controlled trial .
24660789	0	brain-derived_neurotrophic_factor	32,65	BDNF	67,71	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Val/Met polymorphism of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene predicts decline in perceptual speed in older adults .
24708359	0	brain-derived_neurotrophic_factor	17,50	BDNF	52,56	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Investigation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene variants in migraine .
24713358	0	brain-derived_neurotrophic_factor	28,61	BDNF	63,67	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Sex-specific association of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity _ disorder in a drug-na ve Han Chinese sample .
24966334	0	brain-derived_neurotrophic_factor	49,82	BDNF	84,88	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Persistent inflammation-induced up-regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- promotes synaptic delivery of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid receptor GluA1 subunits in descending pain modulatory circuits .
25237300	0	brain-derived_neurotrophic_factor	18,51	BDNF	53,57	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Disruption of the brain-derived_neurotrophic_factor -LRB- BDNF -RRB- immunoreactivity in the human K lliker-Fuse nucleus in victims of unexplained fetal and infant death .
25305432	0	brain-derived_neurotrophic_factor	27,60	BDNF	62,66	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Decreased plasma levels of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- during mixed episodes of bipolar_disorder .
25328348	0	brain-derived_neurotrophic_factor	6,39	BDNF	41,45	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels in schizophrenia : A systematic review .
25653370	0	brain-derived_neurotrophic_factor	12,45	BDNF	47,51	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- in the development of neurogenic detrusor overactivity -LRB- NDO -RRB- .
25710846	0	brain-derived_neurotrophic_factor	33,66	BDNF	68,72	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Meta-analysis and association of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- gene with obsessive-compulsive_disorder .
26347681	0	brain-derived_neurotrophic_factor	4,37	BDNF	39,43	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The brain-derived_neurotrophic_factor -LRB- BDNF -RRB- val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition -LRB- WMS-III -RRB- .
26347681	0	brain-derived_neurotrophic_factor	4,37	BDNF	39,43	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The brain-derived_neurotrophic_factor -LRB- BDNF -RRB- val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition -LRB- WMS-III -RRB- .
26531275	0	brain-derived_neurotrophic_factor	55,88	BDNF	90,94	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Effect of different anesthesia techniques on the serum brain-derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
26736083	0	brain-derived_neurotrophic_factor	14,47	BDNF	49,53	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA in rat retrosplenial cortex following administration of phencyclidine .
7906555	0	brain-derived_neurotrophic_factor	39,72	BDNF	74,78	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Activation of NMDA receptors increases brain-derived_neurotrophic_factor -LRB- BDNF -RRB- mRNA expression in the hippocampal formation .
8126563	0	brain-derived_neurotrophic_factor	14,47	BDNF	49,53	brain-derived neurotrophic factor	BDNF	627	627	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors .
9065491	0	brain-derived_neurotrophic_factor	16,49	BDNF	51,55	brain-derived neurotrophic factor	BDNF	24225(Tax:10116)	24225(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Distribution of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- protein and mRNA in the normal adult rat CNS : evidence for anterograde axonal transport .
9842514	0	brain-derived_neurotrophic_factor	46,79	BDNF	81,85	brain-derived neurotrophic factor	BDNF	100135487(Tax:10141)	100135487(Tax:10141)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Unilateral vestibular deafferentation induces brain-derived_neurotrophic_factor -LRB- BDNF -RRB- protein expression in the guinea_pig lateral but not medial vestibular nuclei .
24351232	0	brain-derived_neurotrophic_factor	16,49	BNDF	51,55	brain-derived neurotrophic factor	BNDF	627	627	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of brain-derived_neurotrophic_factor -LRB- BNDF -RRB- in multiple_sclerosis patients with Trichuris_suis ova therapy .
16778834	0	brain-derived_neurotrophic_factor	25,58	Bim	18,21	brain-derived neurotrophic factor	Bim	627	10018	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Downregulation of Bim by brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death .
16530956	0	brain-derived_neurotrophic_factor	16,49	CA3	87,90	brain-derived neurotrophic factor	CA3	12064(Tax:10090)	12350(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	c-fos modulates brain-derived_neurotrophic_factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons .
19046370	0	brain-derived_neurotrophic_factor	99,132	CREB	79,83	brain-derived neurotrophic factor	CREB	627	1385	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|nsubj|END_ENTITY	Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain-derived_neurotrophic_factor promoter .
17064360	0	brain-derived_neurotrophic_factor	59,92	Calcitonin_gene-related_peptide	0,31	brain-derived neurotrophic factor	Calcitonin gene-related peptide	24225(Tax:10116)	24241(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Calcitonin_gene-related_peptide enhances release of native brain-derived_neurotrophic_factor from trigeminal ganglion neurons .
10513602	0	brain-derived_neurotrophic_factor	40,73	Corticotropin-releasing_factor	0,30	brain-derived neurotrophic factor	Corticotropin-releasing factor	24225(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Corticotropin-releasing_factor enhances brain-derived_neurotrophic_factor gene expression to facilitate memory retention in rats .
17209049	0	brain-derived_neurotrophic_factor	25,58	DARPP-32	72,80	brain-derived neurotrophic factor	DARPP-32	627	84152	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	AKT and CDK5/p35 mediate brain-derived_neurotrophic_factor induction of DARPP-32 in medium size spiny neurons in vitro .
22778217	0	brain-derived_neurotrophic_factor	38,71	ERK5	148,152	brain-derived neurotrophic factor	ERK5	627	5598	Gene	Gene	release|nmod|START_ENTITY increases|dobj|release increases|nmod|glia glia|nmod|progesterone_receptor_membrane_component_1 progesterone_receptor_membrane_component_1|amod|dependent dependent|dep|END_ENTITY	Progesterone increases the release of brain-derived_neurotrophic_factor from glia via progesterone_receptor_membrane_component_1 -LRB- Pgrmc1 -RRB- - dependent ERK5 signaling .
19564905	0	brain-derived_neurotrophic_factor	70,103	Eps8	0,4	brain-derived neurotrophic factor	Eps8	12064(Tax:10090)	13860(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived_neurotrophic_factor -LRB- BDNF -RRB- .
22521589	0	brain-derived_neurotrophic_factor	62,95	GLUT3	121,126	brain-derived neurotrophic factor	GLUT3	627	6515	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Photoperiod and stress regulation of corticosteroid receptor , brain-derived_neurotrophic_factor , and glucose transporter GLUT3 mRNA in the hippocampus of male Siberian hamsters -LRB- Phodopus sungorus -RRB- .
23811393	0	brain-derived_neurotrophic_factor	58,91	Grin2b	120,126	brain-derived neurotrophic factor	Grin2b	24225(Tax:10116)	24410(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Status_epilepticus triggers early and late alterations in brain-derived_neurotrophic_factor and NMDA_glutamate receptor Grin2b DNA methylation levels in the hippocampus .
22853041	0	brain-derived_neurotrophic_factor	31,64	Interleukin_1-beta	0,18	brain-derived neurotrophic factor	Interleukin 1-beta	627	3553	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Interleukin_1-beta upregulates brain-derived_neurotrophic_factor , neurotrophin_3 and neuropilin_2 gene expression and NGF production in annulus cells .
24604632	0	brain-derived_neurotrophic_factor	18,51	MiR-206	0,7	brain-derived neurotrophic factor	MiR-206	12064(Tax:10090)	387202(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY decreases|dobj|levels decreases|nsubj|END_ENTITY	MiR-206 decreases brain-derived_neurotrophic_factor levels in a transgenic mouse model of Alzheimer 's _ disease .
25288805	0	brain-derived_neurotrophic_factor	72,105	Protein-tyrosine_phosphatase_1B	0,31	brain-derived neurotrophic factor	Protein-tyrosine phosphatase 1B	12064(Tax:10090)	19246(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Protein-tyrosine_phosphatase_1B -LRB- PTP1B -RRB- is a novel regulator of central brain-derived_neurotrophic_factor and tropomyosin_receptor_kinase_B -LRB- TrkB -RRB- signaling .
10646517	0	brain-derived_neurotrophic_factor	73,106	Shp-2	0,5	brain-derived neurotrophic factor	Shp-2	24225(Tax:10116)	25622(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Shp-2 specifically regulates several tyrosine-phosphorylated proteins in brain-derived_neurotrophic_factor signaling in cultured cerebral cortical neurons .
22331573	0	brain-derived_neurotrophic_factor	16,49	Sox11	0,5	brain-derived neurotrophic factor	Sox11	12064(Tax:10090)	20666(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Sox11 modulates brain-derived_neurotrophic_factor expression in an exon promoter-specific manner .
12202482	0	brain-derived_neurotrophic_factor	41,74	TRKB	14,18	brain-derived neurotrophic factor	TRKB	627	4915	Gene	Gene	isoforms|compound|START_ENTITY surface|nmod|isoforms surface|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of TRKB surface expression by brain-derived_neurotrophic_factor and truncated TRKB isoforms .
12202482	0	brain-derived_neurotrophic_factor	41,74	TRKB	89,93	brain-derived neurotrophic factor	TRKB	627	4915	Gene	Gene	isoforms|compound|START_ENTITY isoforms|compound|END_ENTITY	Regulation of TRKB surface expression by brain-derived_neurotrophic_factor and truncated TRKB isoforms .
11746354	0	brain-derived_neurotrophic_factor	56,89	Transforming_growth_factor-beta1	0,32	brain-derived neurotrophic factor	Transforming growth factor-beta1	24225(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Transforming_growth_factor-beta1 enhances expression of brain-derived_neurotrophic_factor and its receptor , TrkB , in neurons cultured from rat cerebral cortex .
10446295	0	brain-derived_neurotrophic_factor	94,127	TrkB	0,4	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	receptor|amod|START_ENTITY acts|nmod|receptor acts|nsubj|mutant mutant|compound|END_ENTITY	TrkB mutant lacking the amino-terminal half of the extracellular portion acts as a functional brain-derived_neurotrophic_factor receptor .
10825163	0	brain-derived_neurotrophic_factor	61,94	TrkB	12,16	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	/|compound|START_ENTITY reduces|nmod|/ reduces|dobj|autophosphorylation autophosphorylation|compound|END_ENTITY	p75 reduces TrkB tyrosine autophosphorylation in response to brain-derived_neurotrophic_factor and neurotrophin_4 / 5 .
10833508	0	brain-derived_neurotrophic_factor	19,52	TrkB	0,4	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	TrkB activation by brain-derived_neurotrophic_factor inhibits the G protein-gated inward rectifier Kir3 by tyrosine phosphorylation of the channel .
11516824	0	brain-derived_neurotrophic_factor	19,52	TrkB	53,57	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of the brain-derived_neurotrophic_factor / TrkB pathway in neuroprotecive effect of cyclosporin_A in forebrain_ischemia .
12470870	0	brain-derived_neurotrophic_factor	24,57	TrkB	70,74	brain-derived neurotrophic factor	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|pathway pathway|compound|END_ENTITY	Involvement of a spinal brain-derived_neurotrophic_factor / full-length TrkB pathway in the development of nerve_injury-induced thermal_hyperalgesia in mice .
12691830	0	brain-derived_neurotrophic_factor	45,78	TrkB	93,97	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	activation|amod|START_ENTITY activation|nmod|path path|compound|END_ENTITY	Cisplatin-induced cytotoxicity is blocked by brain-derived_neurotrophic_factor activation of TrkB signal transduction path in neuroblastoma .
12921913	0	brain-derived_neurotrophic_factor	29,62	TrkB	81,85	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of brain-derived_neurotrophic_factor and its receptor , TrkB , in the hippocampal_formation_of_schizophrenic_brains .
15312792	0	brain-derived_neurotrophic_factor	23,56	TrkB	98,102	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	exposure|nmod|START_ENTITY required|nsubjpass|exposure required|nmod|activation activation|nmod|receptor receptor|compound|END_ENTITY	Continuous exposure to brain-derived_neurotrophic_factor is required for persistent activation of TrkB receptor , the ERK signaling pathway , and the induction of neuropeptide_Y production in cortical cultures .
15647480	0	brain-derived_neurotrophic_factor	16,49	TrkB	67,71	brain-derived neurotrophic factor	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	Relationship|nmod|START_ENTITY END_ENTITY|nsubj|Relationship	Relationship of brain-derived_neurotrophic_factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia .
15704182	0	brain-derived_neurotrophic_factor	13,46	TrkB	75,79	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	pro-BDNF|amod|START_ENTITY binds|nsubj|pro-BDNF binds|nmod|END_ENTITY	The secreted brain-derived_neurotrophic_factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC .
15781614	0	brain-derived_neurotrophic_factor	65,98	TrkB	99,103	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	mediator|nmod|START_ENTITY identification|nmod|mediator identification|dep|rescue rescue|compound|END_ENTITY	Genetic and pharmacologic identification of Akt as a mediator of brain-derived_neurotrophic_factor / TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death .
16778834	0	brain-derived_neurotrophic_factor	25,58	TrkB	73,77	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Downregulation of Bim by brain-derived_neurotrophic_factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death .
17959796	0	brain-derived_neurotrophic_factor	35,68	TrkB	70,74	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	channels|nmod|START_ENTITY Regulation|dep|channels END_ENTITY|nsubj|Regulation	Regulation of Na -LRB- v -RRB- 1.2 channels by brain-derived_neurotrophic_factor , TrkB , and associated Fyn kinase .
18020981	0	brain-derived_neurotrophic_factor	101,134	TrkB	135,139	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Targeting Akt to increase the sensitivity of neuroblastoma to chemotherapy : lessons learned from the brain-derived_neurotrophic_factor / TrkB signal transduction pathway .
18436387	0	brain-derived_neurotrophic_factor	72,105	TrkB	136,140	brain-derived neurotrophic factor	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Caffeine prevents age-associated recognition memory decline and changes brain-derived_neurotrophic_factor and tirosine kinase receptor -LRB- TrkB -RRB- content in mice .
18843977	0	brain-derived_neurotrophic_factor	10,43	TrkB	55,59	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	-LSB- Study of brain-derived_neurotrophic_factor activating TrkB signaling cascades in the pathogenesis of multiple_myeloma -RSB- .
19726361	0	brain-derived_neurotrophic_factor	69,102	TrkB	120,124	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY YZ-50|nmod|expression Effect|nmod|YZ-50 END_ENTITY|nsubj|Effect	-LSB- Effect of Polygala tenuifolia Willd YZ-50 on the mRNA expression of brain-derived_neurotrophic_factor and its receptor TrkB in rats with chronic_stress_depression -RSB- .
21988201	0	brain-derived_neurotrophic_factor	65,98	TrkB	25,29	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	signaling|nmod|START_ENTITY changes|acl|signaling changes|nmod|END_ENTITY	Developmental changes of TrkB signaling in response to exogenous brain-derived_neurotrophic_factor in primary cortical neurons .
22442142	0	brain-derived_neurotrophic_factor	47,80	TrkB	125,129	brain-derived neurotrophic factor	TrkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY elevates|nsubj|overexpression elevates|dobj|levels levels|compound|END_ENTITY	Targeted taste cell-specific overexpression of brain-derived_neurotrophic_factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells , increases taste bud size , and promotes gustatory innervation .
22995443	0	brain-derived_neurotrophic_factor	70,103	TrkB	105,109	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived_neurotrophic_factor , TrkB levels in rat induced by corticosterone administration .
25210182	0	brain-derived_neurotrophic_factor	15,48	TrkB	49,53	brain-derived neurotrophic factor	TrkB	627	4915	Gene	Gene	START_ENTITY|parataxis|autocrine/paracrine autocrine/paracrine|nsubj|END_ENTITY	HBZ stimulates brain-derived_neurotrophic_factor / TrkB autocrine/paracrine signaling to promote survival of human T-cell_leukemia_virus_type_1-Infected_T cells .
9538265	0	brain-derived_neurotrophic_factor	44,77	TrkB	130,134	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Comparison of survival-promoting effects of brain-derived_neurotrophic_factor and neurotrophin-3 on PC12h cells stably expressing TrkB receptor .
9628753	0	brain-derived_neurotrophic_factor	14,47	TrkB	74,78	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of brain-derived_neurotrophic_factor and its cognate receptor , TrkB , in the rat suprachiasmatic nucleus .
9677306	0	brain-derived_neurotrophic_factor	49,82	TrkB	161,165	brain-derived neurotrophic factor	TrkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Stimulation|nmod|expression requires|nsubj|Stimulation requires|dobj|phospholipase phospholipase|nmod|sites sites|nmod|receptor receptor|appos|END_ENTITY	Stimulation of neuropeptide_Y gene expression by brain-derived_neurotrophic_factor requires both the phospholipase Cgamma and Shc binding sites on its receptor , TrkB .
21335064	0	brain-derived_neurotrophic_factor	34,67	Tumor_necrosis_factor-a	0,23	brain-derived neurotrophic factor	Tumor necrosis factor-a	24225(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Tumor_necrosis_factor-a increases brain-derived_neurotrophic_factor expression in trigeminal_ganglion neurons in an activity-dependent manner .
17890727	0	brain-derived_neurotrophic_factor	12,45	XBP1	61,65	brain-derived neurotrophic factor	XBP1	627	7494	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced XBP1 splicing during brain development .
21515256	0	brain-derived_neurotrophic_factor	10,43	activity-regulated_cytoskeleton-associated_protein	47,97	brain-derived neurotrophic factor	activity-regulated cytoskeleton-associated protein	24225(Tax:10116)	54323(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of brain-derived_neurotrophic_factor on activity-regulated_cytoskeleton-associated_protein gene expression in primary_frontal_cortical_neurons .
14756823	0	brain-derived_neurotrophic_factor	59,92	beta-amyloid_precursor_protein	14,44	brain-derived neurotrophic factor	beta-amyloid precursor protein	627	351	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of beta-amyloid_precursor_protein expression by brain-derived_neurotrophic_factor involves activation of both the Ras and phosphatidylinositide_3-kinase signalling pathways .
10616798	0	brain-derived_neurotrophic_factor	85,118	c-fos	78,83	brain-derived neurotrophic factor	c-fos	24225(Tax:10116)	314322(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Thromboembolic events lead to cortical_spreading_depression and expression of c-fos , brain-derived_neurotrophic_factor , glial fibrillary acidic protein , and heat_shock_protein_70 mRNA in rats .
16530956	0	brain-derived_neurotrophic_factor	16,49	c-fos	0,5	brain-derived neurotrophic factor	c-fos	12064(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	c-fos modulates brain-derived_neurotrophic_factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons .
22773970	0	brain-derived_neurotrophic_factor	10,43	c-jun	47,52	brain-derived neurotrophic factor	c-jun	12064(Tax:10090)	16476(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of brain-derived_neurotrophic_factor on c-jun expression in the rd mouse retina .
12049326	0	brain-derived_neurotrophic_factor	192,225	extracellular_signal-regulated_kinase	102,139	brain-derived neurotrophic factor	extracellular signal-regulated kinase	24225(Tax:10116)	24338(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY evidence|nmod|role END_ENTITY|dep|evidence	Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular_signal-regulated_kinase -LRB- ERK -RRB- in the dentate gyrus : evidence for a role for brain-derived_neurotrophic_factor .
18243629	0	brain-derived_neurotrophic_factor	19,52	extracellular_signal-regulated_kinase	108,145	brain-derived neurotrophic factor	extracellular signal-regulated kinase	627	5594	Gene	Gene	Neuroprotection|nmod|START_ENTITY requires|nsubj|Neuroprotection requires|dobj|activation activation|nmod|END_ENTITY	Neuroprotection of brain-derived_neurotrophic_factor against hypoxic_injury in vitro requires activation of extracellular_signal-regulated_kinase and phosphatidylinositol_3-kinase .
15579139	0	brain-derived_neurotrophic_factor	77,110	gp120	49,54	brain-derived neurotrophic factor	gp120	627	3700	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 glycoprotein gp120 reduces the levels of brain-derived_neurotrophic_factor in vivo : potential implication for neuronal cell death .
24140302	0	brain-derived_neurotrophic_factor	26,59	interleukin-6	71,84	brain-derived neurotrophic factor	interleukin-6	627	3569	Gene	Gene	Association|nmod|START_ENTITY Association|amod|END_ENTITY	Association between serum brain-derived_neurotrophic_factor and plasma interleukin-6 in major_depressive_disorder with melancholic_features .
12704399	0	brain-derived_neurotrophic_factor	42,75	leptin	96,102	brain-derived neurotrophic factor	leptin	12064(Tax:10090)	16846(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|resistance resistance|compound|END_ENTITY	Anti-obesity and anti-diabetic effects of brain-derived_neurotrophic_factor in rodent models of leptin resistance .
22926857	0	brain-derived_neurotrophic_factor	18,51	miR-206	0,7	brain-derived neurotrophic factor	miR-206	12064(Tax:10090)	387202(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	miR-206 regulates brain-derived_neurotrophic_factor in Alzheimer_disease model .
26601091	0	brain-derived_neurotrophic_factor	22,55	mitogen-activated_protein_kinase_14	86,121	brain-derived neurotrophic factor	mitogen-activated protein kinase 14	24225(Tax:10116)	81649(Tax:10116)	Gene	Gene	tumor_necrosis_factor_alpha|compound|START_ENTITY tumor_necrosis_factor_alpha|nummod|END_ENTITY	Effects of doxepin on brain-derived_neurotrophic_factor , tumor_necrosis_factor_alpha , mitogen-activated_protein_kinase_14 , and AKT1 genes expression in rat hippocampus .
22280975	0	brain-derived_neurotrophic_factor	97,130	nerve_growth_factor	74,93	brain-derived neurotrophic factor	nerve growth factor	24225(Tax:10116)	310738(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Selective inhibition of extracellular_signal-regulated_kinases_1 / 2 blocks nerve_growth_factor to brain-derived_neurotrophic_factor signaling and suppresses the development of and reverses already established pain behavior in rats .
2157470	0	brain-derived_neurotrophic_factor	11,44	nerve_growth_factor_receptor	52,80	brain-derived neurotrophic factor	nerve growth factor receptor	627	4804	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of brain-derived_neurotrophic_factor to the nerve_growth_factor_receptor .
10712639	0	brain-derived_neurotrophic_factor	44,77	neuropeptide_Y	18,32	brain-derived neurotrophic factor	neuropeptide Y	24225(Tax:10116)	24604(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Overexpression of neuropeptide_Y induced by brain-derived_neurotrophic_factor in the rat hippocampus is long lasting .
11689163	0	brain-derived_neurotrophic_factor	101,134	neuropeptide_Y	56,70	brain-derived neurotrophic factor	neuropeptide Y	24225(Tax:10116)	24604(Tax:10116)	Gene	Gene	cultures|nmod|START_ENTITY END_ENTITY|nmod|cultures	Induction of functional and morphological expression of neuropeptide_Y -LRB- NPY -RRB- in cortical cultures by brain-derived_neurotrophic_factor -LRB- BDNF -RRB- : evidence for a requirement for extracellular-regulated_kinase -LRB- ERK -RRB- - dependent and ERK-independent mechanisms .
9677306	0	brain-derived_neurotrophic_factor	49,82	neuropeptide_Y	15,29	brain-derived neurotrophic factor	neuropeptide Y	24225(Tax:10116)	24604(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of neuropeptide_Y gene expression by brain-derived_neurotrophic_factor requires both the phospholipase Cgamma and Shc binding sites on its receptor , TrkB .
12900521	0	brain-derived_neurotrophic_factor	39,72	neurotrophin-3	74,88	brain-derived neurotrophic factor	neurotrophin-3	627	4908	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	The neurotrophins nerve growth factor , brain-derived_neurotrophic_factor , neurotrophin-3 , and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial_asthma .
8492120	0	brain-derived_neurotrophic_factor	52,85	phospholipase_C_gamma_1	25,48	brain-derived neurotrophic factor	phospholipase C gamma 1	24225(Tax:10116)	25738(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rapid phosphorylation of phospholipase_C_gamma_1 by brain-derived_neurotrophic_factor and neurotrophin-3 in cultures of embryonic rat cortical neurons .
16573649	0	brain-derived_neurotrophic_factor	107,140	protein_tyrosine_phosphatase	4,32	brain-derived neurotrophic factor	protein tyrosine phosphatase	627	26191	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The protein_tyrosine_phosphatase , Shp2 , is required for the complete activation of the RAS/MAPK pathway by brain-derived_neurotrophic_factor .
21615740	0	brain-derived_neurotrophic_factor	60,93	tissue_plasminogen_activator	28,56	brain-derived neurotrophic factor	tissue plasminogen activator	627	100128998	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Zinc-triggered induction of tissue_plasminogen_activator by brain-derived_neurotrophic_factor and metalloproteinases .
14678891	0	brain-derived_neurotrophic_factor	18,51	trkB	61,65	brain-derived neurotrophic factor	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	-LSB- Amplification of brain-derived_neurotrophic_factor receptor trkB gene and construction of its eukaryotic expression vector -RSB- .
1645620	0	brain-derived_neurotrophic_factor	25,58	trkB	98,102	brain-derived neurotrophic factor	trkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	factors|amod|START_ENTITY ligands|nsubj|factors ligands|nmod|receptor receptor|amod|tyrosine tyrosine|amod|END_ENTITY	The neurotrophic factors brain-derived_neurotrophic_factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor .
1649702	0	brain-derived_neurotrophic_factor	51,84	trkB	4,8	brain-derived neurotrophic factor	trkB	12064(Tax:10090)	18212(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|kinase kinase|amod|tyrosine tyrosine|amod|END_ENTITY	The trkB tyrosine protein kinase is a receptor for brain-derived_neurotrophic_factor and neurotrophin-3 .
1710174	0	brain-derived_neurotrophic_factor	39,72	trkB	0,4	brain-derived neurotrophic factor	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY encodes|dobj|receptor encodes|nsubj|END_ENTITY	trkB encodes a functional receptor for brain-derived_neurotrophic_factor and neurotrophin-3 but not nerve_growth_factor .
8627351	0	brain-derived_neurotrophic_factor	81,114	trkB	30,34	brain-derived neurotrophic factor	trkB	378585(Tax:8355)	379266(Tax:8355)	Gene	Gene	signaling|amod|START_ENTITY have|nmod|signaling have|csubj|occurring occurring|dobj|receptors receptors|compound|END_ENTITY	Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived_neurotrophic_factor signaling .
8670834	0	brain-derived_neurotrophic_factor	82,115	trkB	46,50	brain-derived neurotrophic factor	trkB	627	4915	Gene	Gene	specificity|nmod|START_ENTITY END_ENTITY|nmod|specificity	A splice variant of the neurotrophin receptor trkB with increased specificity for brain-derived_neurotrophic_factor .
8954962	0	brain-derived_neurotrophic_factor	66,99	trkB	16,20	brain-derived neurotrophic factor	trkB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	encoding|nmod|START_ENTITY gene|acl|encoding gene|amod|END_ENTITY	Mutation of the trkB gene encoding the high-affinity receptor for brain-derived_neurotrophic_factor in stroke-prone spontaneously hypertensive rats .
22015740	0	brain-derived_neurotrophic_factor	14,47	tropomyosin-related_kinase_B	48,76	brain-derived neurotrophic factor	tropomyosin-related kinase B	396186(Tax:9031)	396157(Tax:9031)	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|signaling signaling|nsubj|END_ENTITY	Activation of brain-derived_neurotrophic_factor / tropomyosin-related_kinase_B signaling accompanying filial imprinting in domestic chicks -LRB- Gallus_gallus_domesticus -RRB- .
15839936	0	brain-derived_neurotrophic_factor	41,74	vascular_endothelial_growth_factor	89,123	brain-derived neurotrophic factor	vascular endothelial growth factor	24225(Tax:10116)	83785(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY combined|nsubj|effect combined|nmod|END_ENTITY	The additive erectile recovery effect of brain-derived_neurotrophic_factor combined with vascular_endothelial_growth_factor in a rat model of neurogenic_impotence .
24316448	0	brain-derived_neurotrophic_factor	101,134	vesicular_glutamate_transporter_3	18,51	brain-derived neurotrophic factor	vesicular glutamate transporter 3	24225(Tax:10116)	266767(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	The expression of vesicular_glutamate_transporter_3 and vesicular_monoamine_transporter_2 induced by brain-derived_neurotrophic_factor in dorsal root ganglion neurons in vitro .
17918236	0	brain-derived_neurotropic_factor	25,57	BDNF	59,63	brain-derived neurotropic factor	BDNF	627	627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of the brain-derived_neurotropic_factor -LRB- BDNF -RRB- gene in attention deficit_hyperactivity_disorder .
20097691	0	brain-derived_neurotropic_factor	135,167	PPARalpha	82,91	brain-derived neurotropic factor	PPARalpha	12064(Tax:10090)	19013(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARalpha and FGF21 in mice with hepatic ablation of brain-derived_neurotropic_factor .
9756850	0	brain-enriched_guanylate_kinase-associated_protein	8,58	PSD-95	78,84	brain-enriched guanylate kinase-associated protein	PSD-95	57596	1742	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	BEGAIN -LRB- brain-enriched_guanylate_kinase-associated_protein -RRB- , a novel neuronal PSD-95 / SAP90-binding protein .
26497775	0	brain-muscle-ARNT-like_protein-2	20,52	BMAL2	54,59	brain-muscle-ARNT-like protein-2	BMAL2	56938	56938	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between brain-muscle-ARNT-like_protein-2 -LRB- BMAL2 -RRB- gene polymorphism and type 2 diabetes_mellitus in obese Japanese individuals : A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study .
15225653	0	brain-specific_angiogenesis_inhibitor_3	14,53	BAI3	55,59	brain-specific angiogenesis inhibitor 3	BAI3	210933(Tax:10090)	210933(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of brain-specific_angiogenesis_inhibitor_3 -LRB- BAI3 -RRB- in normal brain and implications for BAI3 in ischemia-induced brain_angiogenesis and malignant_glioma .
17485440	0	brain-specific_homeobox	2,25	Bsx	32,35	brain-specific homeobox	Bsx	244813(Tax:10090)	244813(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A brain-specific_homeobox gene , Bsx , is essential for proper postnatal growth and nursing .
17944879	0	brain-specific_homeobox	27,50	REST	0,4	brain-specific homeobox	REST	244813(Tax:10090)	19712(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	REST is a key regulator in brain-specific_homeobox gene expression during neuronal differentiation .
22609399	0	brain-specific_kinase_2	20,43	Jab1	0,4	brain-specific kinase 2	Jab1	9024	10987	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Jab1 interacts with brain-specific_kinase_2 -LRB- BRSK2 -RRB- and promotes its degradation in the ubiquitin-proteasome pathway .
4797840	0	brain-specific_protein	12,34	S-100	36,41	brain-specific protein	S-100	51673	6285	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Effect of a brain-specific_protein -LRB- S-100 protein -RRB- on the nucleolar RNA polymerase activity in isolated brain nuclei .
26445241	0	brain-type_natriuretic_peptide	52,82	BNP	84,87	brain-type natriuretic peptide	BNP	4879	4879	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Maternal serum atrial natriuretic peptide -LRB- ANP -RRB- and brain-type_natriuretic_peptide -LRB- BNP -RRB- levels in gestational diabetes_mellitus .
10364698	0	brain1	136,142	5-HT1A	42,48	brain1	5-HT1A	192109(Tax:10116)	24473(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of experimental hypothyroidism on 5-HT1A , 5-HT2A receptors , 5-HT uptake sites and tryptophan_hydroxylase activity in mature rat brain1 .
19718764	0	brain_aromatase	20,35	cyp19a1b	37,45	brain aromatase	cyp19a1b	60640(Tax:7955)	60640(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Early regulation of brain_aromatase -LRB- cyp19a1b -RRB- by estrogen receptors during zebrafish development .
25665281	0	brain_derivated_neurotrophic_factor	14,49	TrKB	72,76	brain derivated neurotrophic factor	TrKB	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of brain_derivated_neurotrophic_factor and of its receptors : TrKB and p75NT in normal and bile duct ligated rat liver .
26811602	0	brain_derived-neurotrophic_factor	29,62	Tropomyosin-related_kinase_B	0,28	brain derived-neurotrophic factor	Tropomyosin-related kinase B	627	4915	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Tropomyosin-related_kinase_B / brain_derived-neurotrophic_factor signaling pathway as a potential therapeutic target for colorectal_cancer .
15457498	0	brain_derived_neurotrophic_factor	23,56	BDNF	63,67	brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation screen of the brain_derived_neurotrophic_factor gene -LRB- BDNF -RRB- : identification of several genetic variants and association studies in patients with obesity , eating_disorders , and attention-deficit/hyperactivity _ disorder .
16054725	0	brain_derived_neurotrophic_factor	23,56	BDNF	58,62	brain derived neurotrophic factor	BDNF	12064(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regional expression of brain_derived_neurotrophic_factor -LRB- BDNF -RRB- is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain .
23271640	0	brain_derived_neurotrophic_factor	18,51	BDNF	53,57	brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Reduced levels of brain_derived_neurotrophic_factor -LRB- BDNF -RRB- in the serum of diabetic_retinopathy patients and in the retina of diabetic rats .
24361909	0	brain_derived_neurotrophic_factor	38,71	BDNF	73,77	brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Chronic estradiol treatment decreases brain_derived_neurotrophic_factor -LRB- BDNF -RRB- expression and monoamine levels in the amygdala -- implications for behavioral_disorders .
26118823	0	brain_derived_neurotrophic_factor	132,165	BDNF	167,171	brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Development of a cost-efficient novel method for rapid , concurrent genotyping of five common single nucleotide polymorphisms of the brain_derived_neurotrophic_factor -LRB- BDNF -RRB- gene by tetra-primer amplification refractory mutation system .
26796075	0	brain_derived_neurotrophic_factor	89,122	BDNF	124,128	brain derived neurotrophic factor	BDNF	627	627	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Interaction between different sports branches such as taekwondo , box , athletes and serum brain_derived_neurotrophic_factor -LRB- BDNF -RRB- levels .
22679726	0	brain_derived_neurotrophic_factor	105,138	CA1	193,196	brain derived neurotrophic factor	CA1	24225(Tax:10116)	310218(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of electroacupuncture combined with compound Salviae Miltiorrhizae tablet on the expressions of brain_derived_neurotrophic_factor and vascular_endothelial_growth_factor in hippocampus CA1 of chronic_cerebral_ischemia rats -RSB- .
20335141	0	brain_derived_neurotrophic_factor	22,55	GAP-43	59,65	brain derived neurotrophic factor	GAP-43	24225(Tax:10116)	29423(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of endogenous brain_derived_neurotrophic_factor on GAP-43 expression in the anterior horn of the spinal cord in rats with sciatic_nerve_injury -RSB- .
9367255	0	brain_derived_neurotrophic_factor	103,136	beta-calcitonin_gene-related_peptide	14,50	brain derived neurotrophic factor	beta-calcitonin gene-related peptide	24225(Tax:10116)	24241(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of beta-calcitonin_gene-related_peptide in axotomized rubrospinal neurons and the effect of brain_derived_neurotrophic_factor .
21184749	0	brain_derived_neurotrophic_factor	46,79	somatostatin	14,26	brain derived neurotrophic factor	somatostatin	24225(Tax:10116)	24797(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of somatostatin gene expression by brain_derived_neurotrophic_factor in fetal rat cerebrocortical cells .
11532338	0	brain_derived_neurotrophic_factor	116,149	tyrosine_kinase_B	59,76	brain derived neurotrophic factor	tyrosine kinase B	24225(Tax:10116)	25054(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine_kinase_B -LRB- trkB -RRB- , the high-affinity receptor for brain_derived_neurotrophic_factor -LRB- BDNF -RRB- .
9096764	0	brain_finger_protein	4,24	ZNF179	31,37	brain finger protein	ZNF179	7732	7732	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The brain_finger_protein gene -LRB- ZNF179 -RRB- , a member of the RING finger family , maps within the Smith-Magenis_syndrome region at 17p11 .2 .
17890872	0	brain_natriuretic_peptide	31,56	Adiponectin	0,11	brain natriuretic peptide	Adiponectin	4879	9370	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Adiponectin is associated with brain_natriuretic_peptide and left_ventricular_hypertrophy in hemodialysis patients with type_2_diabetes_mellitus .
11108284	0	brain_natriuretic_peptide	17,42	BNP	44,47	brain natriuretic peptide	BNP	100885766	100885766	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Atrial -LRB- ANP -RRB- and brain_natriuretic_peptide -LRB- BNP -RRB- expression after myocardial_infarction in sheep : ANP is synthesized by fibroblasts infiltrating the infarct .
11249937	0	brain_natriuretic_peptide	21,46	BNP	48,51	brain natriuretic peptide	BNP	4879	4879	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|appos|END_ENTITY	Degradation of human brain_natriuretic_peptide -LRB- BNP -RRB- by contact activation of blood_coagulation system .
17954830	0	brain_natriuretic_peptide	8,33	BNP	35,38	brain natriuretic peptide	BNP	4879	4879	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of brain_natriuretic_peptide -LRB- BNP -RRB- in risk stratification of adult_syncope .
20226544	0	brain_natriuretic_peptide	35,60	BNP	62,65	brain natriuretic peptide	BNP	4879	4879	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Diagnostic and prognostic value of brain_natriuretic_peptide -LRB- BNP -RRB- concentrations in very elderly heart_disease patients : specific geriatric cut-off and impacts of age , gender , renal_dysfunction , and nutritional status .
20456197	0	brain_natriuretic_peptide	36,61	BNP	63,66	brain natriuretic peptide	BNP	4879	4879	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	An obesity drug sibutramine reduces brain_natriuretic_peptide -LRB- BNP -RRB- levels in severely obese patients .
21340382	0	brain_natriuretic_peptide	44,69	BNP	71,74	brain natriuretic peptide	BNP	396844(Tax:9823)	396844(Tax:9823)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Pulmonary artery perfusion does not improve brain_natriuretic_peptide -LRB- BNP -RRB- levels in suine experimental research .
22368903	0	brain_natriuretic_peptide	149,174	BNP	176,179	brain natriuretic peptide	BNP	4879	4879	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The role of leukocyte counts in patients with unstable angina_pectoris or myocardial_infarction ; prognostic significance and correlation with plasma brain_natriuretic_peptide -LRB- BNP -RRB- levels .
2521447	0	brain_natriuretic_peptide	21,46	BNP	48,51	brain natriuretic peptide	BNP	4879	4879	Gene	Gene	detection|amod|START_ENTITY detection|appos|END_ENTITY	Radioimmunoassay for brain_natriuretic_peptide -LRB- BNP -RRB- detection of BNP in canine brain .
2521447	0	brain_natriuretic_peptide	21,46	BNP	66,69	brain natriuretic peptide	BNP	4879	4879	Gene	Gene	detection|amod|START_ENTITY detection|nmod|END_ENTITY	Radioimmunoassay for brain_natriuretic_peptide -LRB- BNP -RRB- detection of BNP in canine brain .
2525217	0	brain_natriuretic_peptide	39,64	BNP	66,69	brain natriuretic peptide	BNP	25105(Tax:10116)	25105(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Natriuretic and hypotensive effects of brain_natriuretic_peptide -LRB- BNP -RRB- in spontaneously hypertensive rats .
12067842	0	brain_natriuretic_peptide	24,49	GATA-4	58,64	brain natriuretic peptide	GATA-4	4879	2626	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the human brain_natriuretic_peptide gene by GATA-4 .
20170659	0	brain_natriuretic_peptide	34,59	X-box_binding_protein_1	0,23	brain natriuretic peptide	X-box binding protein 1	4879	7494	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	X-box_binding_protein_1 regulates brain_natriuretic_peptide through a novel AP1/CRE-like element in cardiomyocytes .
18712036	0	brain_natriuretic_peptide	45,70	adiponectin	7,18	brain natriuretic peptide	adiponectin	4879	9370	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Plasma adiponectin is associated with plasma brain_natriuretic_peptide and cardiac function in healthy subjects .
1864303	0	brain_natriuretic_peptide	11,36	renin	40,45	brain natriuretic peptide	renin	487441(Tax:9615)	403838(Tax:9615)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of brain_natriuretic_peptide on renin secretion in normal and hypertonic saline-infused kidney .
18026869	0	brain_protein_44-like	38,59	Brp44l	61,67	brain protein 44-like	Brp44l	51660	51660	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The molecular characterization of the brain_protein_44-like -LRB- Brp44l -RRB- gene of Gekko japonicus and its expression changes in spinal cord after tail amputation .
26773365	0	brain_ribonuclease	11,29	BRB	31,34	brain ribonuclease	BRB	280720(Tax:9913)	280720(Tax:9913)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in brain_ribonuclease -LRB- BRB -RRB- messenger RNA in granulosa cells -LRB- GCs -RRB- of dominant vs subordinate ovarian follicles of cattle and the regulation of BRB gene expression in bovine GCs .
25932235	0	brain_type_natriuretic_peptide	21,51	BNP	53,56	brain type natriuretic peptide	BNP	4879	4879	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of serum brain_type_natriuretic_peptide -LRB- BNP -RRB- in patients with Crimean-Congo_hemorrhagic_fever .
17503969	0	brakeless	11,20	atrophin	36,44	brakeless	atrophin	44027(Tax:7227)	46156(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos .
17150414	0	branched_chain_aminotransferase	24,55	BCATc	57,62	branched chain aminotransferase	BCATc	12035(Tax:10090)	12035(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cytosolic branched_chain_aminotransferase -LRB- BCATc -RRB- mRNA in the developing mouse brain .
23975899	0	brassinosteroid_insensitive1	58,86	AP-2	29,33	brassinosteroid insensitive1	AP-2	830095(Tax:3702)	829845(Tax:3702)	Gene	Gene	endocytosis|nmod|START_ENTITY mediates|dobj|endocytosis mediates|nsubj|END_ENTITY	The clathrin adaptor complex AP-2 mediates endocytosis of brassinosteroid_insensitive1 in Arabidopsis .
9405383	0	brca2	108,113	RAD51	0,5	brca2	RAD51	675	5888	Gene	Gene	conserved|nmod|START_ENTITY conserved|nsubj|interacts interacts|nummod|END_ENTITY	RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast_cancer susceptibility gene brca2 .
15087374	0	breakpoint-cluster_region	68,93	MLL	107,110	breakpoint-cluster region	MLL	613	4297	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster_region of the human MLL gene .
25671650	0	breakpoint_cluster_region_protein	47,80	Huntingtin-associated_protein_1	0,31	breakpoint cluster region protein	Huntingtin-associated protein 1	110279(Tax:10090)	15114(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Huntingtin-associated_protein_1 interacts with breakpoint_cluster_region_protein to regulate neuronal differentiation .
15563594	0	breast-cancer-associated_gene_1	18,49	BRCA1	51,56	breast-cancer-associated gene 1	BRCA1	12189(Tax:10090)	12189(Tax:10090)	Gene	Gene	requirement|nmod|START_ENTITY requirement|appos|END_ENTITY	A requirement for breast-cancer-associated_gene_1 -LRB- BRCA1 -RRB- in the spindle checkpoint .
16617102	0	breast_cancer_amplified_sequence_3	37,71	MTA1	0,4	breast cancer amplified sequence 3	MTA1	54828	9112	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	MTA1 , a transcriptional activator of breast_cancer_amplified_sequence_3 .
22816673	0	breast_cancer_anti-estrogen_resistance_1	14,54	vascular_endothelial_growth_factor	70,104	breast cancer anti-estrogen resistance 1	vascular endothelial growth factor	9564	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of breast_cancer_anti-estrogen_resistance_1 in relation to vascular_endothelial_growth_factor , p53 , and prognosis in esophageal_squamous_cell_cancer .
25187687	0	breast_cancer_metastasis_suppressor_1	46,83	BRMS1	85,90	breast cancer metastasis suppressor 1	BRMS1	25855	25855	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Modelling and simulation of mutant alleles of breast_cancer_metastasis_suppressor_1 -LRB- BRMS1 -RRB- gene .
14973083	0	breast_cancer_resistance_protein	59,91	ABCG2	93,98	breast cancer resistance protein	ABCG2	9429	9429	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel estrogen response element in the breast_cancer_resistance_protein -LRB- ABCG2 -RRB- gene .
16146333	0	breast_cancer_resistance_protein	12,44	ABCG2	46,51	breast cancer resistance protein	ABCG2	9429	9429	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the breast_cancer_resistance_protein -LRB- ABCG2 -RRB- in drug transport .
19170519	0	breast_cancer_resistance_protein	35,67	ABCG2	69,74	breast cancer resistance protein	ABCG2	9429	9429	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|appos|END_ENTITY	Potent and selective inhibitors of breast_cancer_resistance_protein -LRB- ABCG2 -RRB- derived from the p-glycoprotein -LRB- ABCB1 -RRB- modulator tariquidar .
19572416	0	breast_cancer_resistance_protein	63,95	ABCG2	103,108	breast cancer resistance protein	ABCG2	9429	9429	Gene	Gene	START_ENTITY|appos|BCRP BCRP|dep|END_ENTITY	A fluorescence-based in vitro assay for drug interactions with breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- .
20854129	0	breast_cancer_resistance_protein	27,59	ABCG2	67,72	breast cancer resistance protein	ABCG2	9429	9429	Gene	Gene	START_ENTITY|appos|BCRP BCRP|dep|END_ENTITY	Fetoprotective activity of breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- : expression and function throughout pregnancy .
20952483	0	breast_cancer_resistance_protein	16,48	ABCG2	50,55	breast cancer resistance protein	ABCG2	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the breast_cancer_resistance_protein -LRB- ABCG2 -RRB- in the distribution of sorafenib to the brain .
23539627	0	breast_cancer_resistance_protein	75,107	ABCG2	109,114	breast cancer resistance protein	ABCG2	9429	9429	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	IMP3 protein promotes chemoresistance in breast_cancer cells by regulating breast_cancer_resistance_protein -LRB- ABCG2 -RRB- expression .
11566359	0	breast_cancer_resistance_protein	64,96	ATP-binding_cassette_transporter_G2	98,133	breast cancer resistance protein	ATP-binding cassette transporter G2	9429	9429	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Promoter characterization and genomic organization of the human breast_cancer_resistance_protein -LRB- ATP-binding_cassette_transporter_G2 -RRB- gene .
11986234	0	breast_cancer_resistance_protein	27,59	BCRP	61,65	breast cancer resistance protein	BCRP	9429	9429	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and activity of breast_cancer_resistance_protein -LRB- BCRP -RRB- in de novo and relapsed acute_myeloid_leukemia .
14645676	0	breast_cancer_resistance_protein	37,69	BCRP	71,75	breast cancer resistance protein	BCRP	9429	9429	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of human breast_cancer_resistance_protein -LRB- BCRP , ABCG2 -RRB- expressed in the oocytes of Xenopus_laevis .
14989769	0	breast_cancer_resistance_protein	67,99	BCRP	101,105	breast cancer resistance protein	BCRP	9429	9429	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Relationship between resistance to chemotherapy and expression of breast_cancer_resistance_protein -LRB- BCRP -RRB- gene in patients with acute_leukemia -RSB- .
15946326	0	breast_cancer_resistance_protein	16,48	BCRP	50,54	breast cancer resistance protein	BCRP	9429	9429	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of breast_cancer_resistance_protein -LRB- BCRP -RRB- in microvessel endothelium of human control and epileptic brain .
18255023	0	breast_cancer_resistance_protein	31,63	BCRP	65,69	breast cancer resistance protein	BCRP	9429	9429	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localisation of breast_cancer_resistance_protein -LRB- BCRP -RRB- in human fetal membranes and decidua and the influence of labour at term .
23402418	0	breast_cancer_resistance_protein	25,57	BCRP	59,63	breast cancer resistance protein	BCRP	9429	9429	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Revolving door action of breast_cancer_resistance_protein -LRB- BCRP -RRB- facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells .
25502234	0	breast_cancer_resistance_protein	8,40	BCRP	42,46	breast cancer resistance protein	BCRP	9429	9429	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of breast_cancer_resistance_protein -LRB- BCRP -RRB- as active efflux transporter on blood-brain barrier -LRB- BBB -RRB- permeability .
22581381	0	breast_cancer_resistance_protein	16,48	Bcrp	50,54	breast cancer resistance protein	Bcrp	9429	9429	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of breast_cancer_resistance_protein -LRB- Bcrp -RRB- in endocrine organs and inhibition of its transport activity by steroid hormones .
21602547	0	breast_cancer_resistance_protein	39,71	Bcrp1	73,78	breast cancer resistance protein	Bcrp1	26357(Tax:10090)	26357(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Glucocorticoid regulation of placental breast_cancer_resistance_protein -LRB- Bcrp1 -RRB- in the mouse .
19270061	0	breast_cancer_resistance_protein	52,84	MicroRNA-328	0,12	breast cancer resistance protein	MicroRNA-328	9429	442901	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-328 negatively regulates the expression of breast_cancer_resistance_protein -LRB- BCRP/ABCG2 -RRB- in human cancer cells .
18588889	0	breast_cancer_resistance_protein	44,76	P-glycoprotein	0,14	breast cancer resistance protein	P-glycoprotein	9429	5243	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	P-glycoprotein down-regulates expression of breast_cancer_resistance_protein in a drug-free state .
21816982	0	breast_cancer_resistance_protein	16,48	PDZK1	0,5	breast cancer resistance protein	PDZK1	26357(Tax:10090)	59020(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PDZK1 regulates breast_cancer_resistance_protein in small intestine .
22348324	0	breast_cancer_resistance_protein	36,68	Progesterone_receptor	0,21	breast cancer resistance protein	Progesterone receptor	9429	5241	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Progesterone_receptor downregulates breast_cancer_resistance_protein expression via binding to the progesterone response element in breast_cancer .
17220244	0	breast_cancer_resistance_protein	35,67	cyclosporin_a	16,29	breast cancer resistance protein	cyclosporin a	9429	1161	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of cyclosporin_a with breast_cancer_resistance_protein .
19170519	0	breast_cancer_resistance_protein	35,67	p-glycoprotein	93,107	breast cancer resistance protein	p-glycoprotein	9429	5243	Gene	Gene	inhibitors|nmod|START_ENTITY derived|nsubj|inhibitors derived|nmod|tariquidar tariquidar|amod|END_ENTITY	Potent and selective inhibitors of breast_cancer_resistance_protein -LRB- ABCG2 -RRB- derived from the p-glycoprotein -LRB- ABCB1 -RRB- modulator tariquidar .
19414556	0	breast_regression_protein_39	8,36	chitinase_3-like-1	46,64	breast regression protein 39	chitinase 3-like-1	12654(Tax:10090)	12654(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	Role of breast_regression_protein_39 -LRB- BRP-39 -RRB- / chitinase_3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis .
16568091	0	breast_tumor_kinase	51,70	STAT3	18,23	breast tumor kinase	STAT3	5753	6774	Gene	Gene	substrate|nmod|START_ENTITY Identification|nmod|substrate Identification|nmod|END_ENTITY	Identification of STAT3 as a specific substrate of breast_tumor_kinase .
22547065	0	breast_tumor_kinase	44,63	STAT3	78,83	breast tumor kinase	STAT3	5753	6774	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Suppressor_of_cytokine_signaling_3 inhibits breast_tumor_kinase activation of STAT3 .
1325393	0	breathless	0,10	FGF_receptor	25,37	breathless	FGF receptor	39564(Tax:7227)	39564(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	breathless , a Drosophila FGF_receptor homolog , is essential for migration of tracheal and specific midline glial cells .
8125257	0	breathless	27,37	FGF_receptor	52,64	breathless	FGF receptor	39564(Tax:7227)	39564(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Elucidation of the role of breathless , a Drosophila FGF_receptor homolog , in tracheal cell migration .
26553192	0	brg1	22,26	Med14	0,5	brg1	Med14	353295(Tax:7955)	336923(Tax:7955)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest .
22281836	0	bridging_integrator_1	20,41	BIN1	43,47	bridging integrator 1	BIN1	274	274	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of bridging_integrator_1 -LRB- BIN1 -RRB- as a potential tumor suppressor and prognostic marker in hepatocellular_carcinoma .
15522178	0	bridging_integrator_protein-1	56,85	BIN1	87,91	bridging integrator protein-1	BIN1	274	274	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of estrogen_sulfotransferase -LRB- EST -RRB- gene and bridging_integrator_protein-1 -LRB- BIN1 -RRB- gene and their significance in breast tissues -RSB- .
24198243	0	bromodomain-containing_protein_7	29,61	BRD7	63,67	bromodomain-containing protein 7	BRD7	26992(Tax:10090)	26992(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Tumor suppressive effects of bromodomain-containing_protein_7 -LRB- BRD7 -RRB- in epithelial_ovarian_carcinoma .
25716692	0	bromodomain_PHD-finger_transcription_factor	31,74	vimentin	120,128	bromodomain PHD-finger transcription factor	vimentin	2186	7431	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	The prognostic significance of bromodomain_PHD-finger_transcription_factor in colorectal_carcinoma and association with vimentin and E-cadherin .
24840027	0	bromodomain_containing_7	60,84	BRD7	86,90	bromodomain containing 7	BRD7	29117	29117	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Targeting the anaphase-promoting complex/cyclosome -LRB- APC/C -RRB- - bromodomain_containing_7 -LRB- BRD7 -RRB- pathway for human osteosarcoma .
24497639	0	bromodomain_protein_4	16,37	BRD4	39,43	bromodomain protein 4	BRD4	23476	23476	Gene	Gene	interactions|amod|START_ENTITY interactions|appos|END_ENTITY	Affinity map of bromodomain_protein_4 -LRB- BRD4 -RRB- interactions with the histone H4 tail and the small molecule inhibitor JQ1 .
20538714	0	bromodomain_testis-specific	46,73	BRDT	75,79	bromodomain testis-specific	BRDT	676	676	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The interaction of modified histones with the bromodomain_testis-specific -LRB- BRDT -RRB- gene and its mRNA level in sperm of fertile donors and subfertile men .
10704737	0	bromodomain_testis-specific_gene	67,99	CT9	125,128	bromodomain testis-specific gene	CT9	676	676	Gene	Gene	START_ENTITY|nmod|gene gene|appos|END_ENTITY	Expression of cancer-testis antigens in lung_cancer : definition of bromodomain_testis-specific_gene -LRB- BRDT -RRB- as a new CT gene , CT9 .
7886003	0	brown	10,15	dopachrome_tautomerase	49,71	brown	dopachrome tautomerase	22178(Tax:10090)	13190(Tax:10090)	Gene	Gene	locus|nsubj|START_ENTITY locus|nmod|END_ENTITY	The mouse brown -LRB- b -RRB- locus protein functions as a dopachrome_tautomerase .
9889005	0	bub1	49,53	bub1b	34,39	bub1	bub1b	12235(Tax:10090)	12236(Tax:10090)	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	The mouse mitotic checkpoint gene bub1b , a novel bub1 family member , is expressed in a cell cycle-dependent manner .
9889005	0	bub1b	34,39	bub1	49,53	bub1b	bub1	12236(Tax:10090)	12235(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|amod|END_ENTITY	The mouse mitotic checkpoint gene bub1b , a novel bub1 family member , is expressed in a cell cycle-dependent manner .
12242018	0	budding_uninhibited_by_benomyl	52,82	BUB3	84,88	budding uninhibited by benomyl	BUB3	9184	9184	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Molecular cloning and characterization of the human budding_uninhibited_by_benomyl -LRB- BUB3 -RRB- promoter .
8349819	0	bullous_pemphigoid_antigen	17,43	BPAG1	50,55	bullous pemphigoid antigen	BPAG1	667	667	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human 230-kD bullous_pemphigoid_antigen gene -LRB- BPAG1 -RRB- .
10504454	0	bullous_pemphigoid_antigen_1	24,52	BPAG1	54,59	bullous pemphigoid antigen 1	BPAG1	667	667	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of epidermal bullous_pemphigoid_antigen_1 -LRB- BPAG1 -RRB- synthesis by homeoprotein transcription factors .
8547445	0	buspirone	22,31	Prolactin	0,9	prolactin	Prolactin	5617	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to buspirone challenge in the presence of dopaminergic blockade .
11733654	0	butyrylcholinesterase	51,72	BCHE	74,78	butyrylcholinesterase	BCHE	590	590	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of missense mutation -LRB- G365R -RRB- of the butyrylcholinesterase -LRB- BCHE -RRB- gene in a Japanese patient with familial_cholinesterasemia .
15781196	0	butyrylcholinesterase	45,66	BCHE	26,30	butyrylcholinesterase	BCHE	590	590	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Four new mutations in the BCHE gene of human butyrylcholinesterase in a Brazilian blood donor sample .
17700357	0	butyrylcholinesterase	102,123	BCHE	83,87	butyrylcholinesterase	BCHE	590	590	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Expression of three naturally occurring genetic variants -LRB- G75R , E90D , I99M -RRB- of the BCHE gene of human butyrylcholinesterase .
17996334	0	butyrylcholinesterase	72,93	BCHE	95,99	butyrylcholinesterase	BCHE	590	590	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Influence of genetic polymorphisms in the apolipoprotein -LRB- APOE -RRB- and the butyrylcholinesterase -LRB- BCHE -RRB- gene on stress markers in older adults : a 3-year study .
8554068	0	butyrylcholinesterase	51,72	BCHE	74,78	butyrylcholinesterase	BCHE	590	590	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of 12 silent alleles of the human butyrylcholinesterase -LRB- BCHE -RRB- gene .
17350607	0	butyrylcholinesterase	17,38	BChE	40,44	butyrylcholinesterase	BChE	590	590	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of butyrylcholinesterase -LRB- BChE -RRB- phenotypes to predict the risk of prolonged apnea in persons receiving succinylcholine in the healthy population of western Iran .
10190043	0	butyrylcholinesterase	35,56	Cd2	60,63	butyrylcholinesterase	Cd2	101102112	101106727	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Inhibition kinetics of human serum butyrylcholinesterase by Cd2 + , Zn2 + and Al3 + : comparison of the effects of metal ions on cholinesterases .
20944437	0	butyrylcholinesterase	30,51	Paraoxonase_1	0,13	butyrylcholinesterase	Paraoxonase 1	590	5444	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Paraoxonase_1 correlates with butyrylcholinesterase and gamma_glutamyl_transferase in workers chronically exposed to pesticides .
25646463	0	butyrylcholinesterase	7,28	ghrelin	39,46	butyrylcholinesterase	ghrelin	12038(Tax:10090)	58991(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Plasma butyrylcholinesterase regulates ghrelin to control aggression .
25646463	0	butyrylcholinesterase	7,28	ghrelin	39,46	butyrylcholinesterase	ghrelin	12038(Tax:10090)	58991(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Plasma butyrylcholinesterase regulates ghrelin to control aggression .
17055491	0	bystin	23,29	Bysl	4,8	bystin	Bysl	705	53414(Tax:10090)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	The Bysl gene product , bystin , is essential for survival of mouse embryos .
19285032	0	c-ABL	0,5	RAD51	33,38	c-ABL	RAD51	25	5888	Gene	Gene	kinase|amod|START_ENTITY stabilizes|nsubj|kinase stabilizes|dobj|association association|nummod|END_ENTITY	c-ABL tyrosine kinase stabilizes RAD51 chromatin association .
12028026	0	c-ABL	77,82	p53	0,3	c-ABL	p53	25	7157	Gene	Gene	kinases|amod|START_ENTITY cleavage|nmod|kinases associated|nmod|cleavage associated|nsubjpass|expression expression|compound|END_ENTITY	p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases .
12777393	0	c-Abl	12,17	Abl	32,35	c-Abl	Abl	25	25	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization .
26235616	0	c-Abl	0,5	Aha1	43,47	c-Abl	Aha1	25	10598	Gene	Gene	Phosphorylation|amod|START_ENTITY Phosphorylation|nmod|END_ENTITY	c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells .
15148308	0	c-Abl	0,5	Dok1	21,25	c-Abl	Dok1	11350(Tax:10090)	13448(Tax:10090)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Abl phosphorylates Dok1 to promote filopodia during cell spreading .
23581475	0	c-Abl	0,5	E6AP	21,25	c-Abl	E6AP	25	7337	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity .
26400984	0	c-Abl	34,39	ERK1/2	41,47	c-Abl	ERK1/2	25	5595;5594	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|dep|END_ENTITY	MicroRNA-203 negatively regulates c-Abl , ERK1/2 phosphorylation , and proliferation in smooth muscle cells .
24658113	0	c-Abl	20,25	EphA4	0,5	c-Abl	EphA4	25	2043	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-b oligomers .
12893824	0	c-Abl	45,50	Glutathione_peroxidase_1	0,24	c-Abl	Glutathione peroxidase 1	25	2876	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Glutathione_peroxidase_1 is regulated by the c-Abl and Arg tyrosine kinases .
16702947	0	c-Abl	0,5	Hdm2	21,25	c-Abl	Hdm2	25	4193	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF .
19075013	0	c-Abl	0,5	Hdmx	21,25	c-Abl	Hdmx	25	4193	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Abl phosphorylates Hdmx and regulates its interaction with p53 .
21220745	0	c-Abl	0,5	Mcl-1	16,21	c-Abl	Mcl-1	25	4170	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	c-Abl regulates Mcl-1 gene expression in chronic_lymphocytic_leukemia cells .
10085066	0	c-Abl	0,5	Mdm2	43,47	c-Abl	Mdm2	25	4193	Gene	Gene	neutralizes|nsubj|START_ENTITY neutralizes|dobj|effect effect|nmod|END_ENTITY	c-Abl neutralizes the inhibitory effect of Mdm2 on p53 .
21081495	0	c-Abl	0,5	Mdm2	25,29	c-Abl	Mdm2	11350(Tax:10090)	17246(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation .
18160052	0	c-Abl	64,69	NOX5	36,40	c-Abl	NOX5	25	79400	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl .
24190424	0	c-Abl	10,15	PC-3	28,32	c-Abl	PC-3	25	57332	Gene	Gene	activity|amod|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Decreased c-Abl activity in PC-3 and LNCaP_prostate_cancer cells overexpressing the early growth response-1 protein .
22238610	0	c-Abl	62,67	PCNA	51,55	c-Abl	PCNA	25	5111	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of proliferation cell nuclear antigen -LRB- PCNA -RRB- with c-Abl in cell proliferation and response to DNA damages in breast_cancer .
17030193	0	c-Abl	50,55	PPARgamma	22,31	c-Abl	PPARgamma	25	5468	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Acetaldehyde inhibits PPARgamma via H2O2-mediated c-Abl activation in human hepatic stellate cells .
19427856	0	c-Abl	13,18	Rad51	54,59	c-Abl	Rad51	25	5888	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Detection of c-Abl kinase-promoted phosphorylation of Rad51 by specific antibodies reveals that Y54 phosphorylation is dependent on that of Y315 .
9461559	0	c-Abl	32,37	Rad51	14,19	c-Abl	Rad51	25	5888	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Rad51 function by c-Abl in response to DNA damage .
16867995	0	c-Abl	46,51	Transforming_growth_factor_beta	0,31	c-Abl	Transforming growth factor beta	25	7040	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Transforming_growth_factor_beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures .
22558212	0	c-Abl	14,19	YAP1	0,4	c-Abl	YAP1	25	10413	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	YAP1 recruits c-Abl to protect angiomotin-like_1 from Nedd4-mediated degradation .
18280240	0	c-Abl	24,29	Yap1	0,4	c-Abl	Yap1	25	10413	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage .
24412932	0	c-Abl	0,5	a-synuclein	21,32	c-Abl	a-synuclein	25	6622	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Abl phosphorylates a-synuclein and regulates its degradation : implication for a-synuclein clearance and contribution to the pathogenesis of Parkinson 's _ disease .
22879933	0	c-Abl	0,5	acid_sphingomyelinase	34,55	c-Abl	acid sphingomyelinase	25	6609	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	c-Abl is an upstream regulator of acid_sphingomyelinase in apoptosis induced by inhibition of integrins avb3 and avb5 .
16901904	0	c-Abl	20,25	c-Jun	35,40	c-Abl	c-Jun	11350(Tax:10090)	16476(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells .
11847100	0	c-Abl	0,5	c-myc	54,59	c-Abl	c-myc	25	4609	Gene	Gene	effector|nsubj|START_ENTITY effector|nmod|Src Src|nmod|expression expression|amod|END_ENTITY	c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis .
8063836	0	c-Abl	34,39	c-myc	14,19	c-Abl	c-myc	25	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of c-myc expression by c-Abl is independent of both the DNA binding function of c-Abl and the c-myc EP site .
8063836	0	c-Abl	91,96	c-myc	14,19	c-Abl	c-myc	25	4609	Gene	Gene	function|nmod|START_ENTITY independent|nmod|function independent|nsubj|Activation Activation|nmod|expression expression|amod|END_ENTITY	Activation of c-myc expression by c-Abl is independent of both the DNA binding function of c-Abl and the c-myc EP site .
20101225	0	c-Abl	0,5	estrogen_receptor_alpha	16,39	c-Abl	estrogen receptor alpha	25	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	c-Abl regulates estrogen_receptor_alpha transcription activity through its stabilization by phosphorylation .
17620332	0	c-Abl	8,13	insulin_receptor	65,81	c-Abl	insulin receptor	11350(Tax:10090)	16337(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of c-Abl in directing metabolic versus mitogenic effects in insulin_receptor signaling .
24923444	0	c-Abl	0,5	janus_kinase_2	16,30	c-Abl	janus kinase 2	11350(Tax:10090)	16452(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	c-Abl activates janus_kinase_2 in normal hematopoietic cells .
10708759	0	c-Abl	93,98	nerve_growth_factor_receptor	22,50	c-Abl	nerve growth factor receptor	25	4804	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of nerve_growth_factor_receptor , TrkA , with non-receptor tyrosine kinase , c-Abl , through the activation loop .
10085066	0	c-Abl	0,5	p53	51,54	c-Abl	p53	25	7157	Gene	Gene	neutralizes|nsubj|START_ENTITY neutralizes|dobj|effect effect|nmod|Mdm2 Mdm2|nmod|END_ENTITY	c-Abl neutralizes the inhibitory effect of Mdm2 on p53 .
10629029	0	c-Abl	34,39	p53	15,18	c-Abl	p53	25	7157	Gene	Gene	binding|nmod|START_ENTITY DNA|amod|binding DNA|compound|END_ENTITY	Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization .
10629029	0	c-Abl	34,39	p53	53,56	c-Abl	p53	25	7157	Gene	Gene	binding|nmod|START_ENTITY DNA|amod|binding Stimulation|nmod|DNA requires|nsubj|Stimulation requires|dobj|terminus terminus|nummod|END_ENTITY	Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization .
10805805	0	c-Abl	0,5	p53	83,86	c-Abl	p53	11350(Tax:10090)	22060(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|proliferation proliferation|nmod|context context|nmod|deficiency deficiency|compound|END_ENTITY	c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency .
11486026	0	c-Abl	0,5	p53	16,19	c-Abl	p53	25	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|compound|END_ENTITY	c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination .
12110584	0	c-Abl	36,41	p53	60,63	c-Abl	p53	25	7157	Gene	Gene	Mdm2|nmod|START_ENTITY phosphorylation|nmod|Mdm2 phosphorylation|dep|implications implications|nmod|regulation regulation|compound|END_ENTITY	Tyrosine phosphorylation of Mdm2 by c-Abl : implications for p53 regulation .
15661746	0	c-Abl	57,62	p53	38,41	c-Abl	p53	25	7157	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|Insights Insights|nmod|activation activation|nmod|DNA DNA|compound|END_ENTITY	Insights into selective activation of p53 DNA binding by c-Abl .
16636310	0	c-Abl	71,76	p53	25,28	c-Abl	p53	25	7157	Gene	Gene	reductions|nmod|START_ENTITY accompanied|nmod|reductions accompanied|nsubjpass|accumulations accumulations|nmod|END_ENTITY	Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells .
17339230	0	c-Abl	0,5	p53	71,74	c-Abl	p53	25	7157	Gene	Gene	kinase|amod|START_ENTITY activates|nsubj|kinase activates|nmod|END_ENTITY	c-Abl tyrosine kinase activates p21 transcription via interaction with p53 .
18490454	0	c-Abl	21,26	p53	53,56	c-Abl	p53	25	7157	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress .
19075013	0	c-Abl	0,5	p53	61,64	c-Abl	p53	25	7157	Gene	Gene	phosphorylates|amod|START_ENTITY Hdmx|nsubj|phosphorylates Hdmx|nmod|END_ENTITY	c-Abl phosphorylates Hdmx and regulates its interaction with p53 .
26810274	0	c-Abl	0,5	p53	52,55	c-Abl	p53	11350(Tax:10090)	22060(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|apoptosis apoptosis|nmod|END_ENTITY	c-Abl contributes to glucose-promoted apoptosis via p53 signaling pathway in podocytes .
7651743	0	c-Abl	40,45	p53	0,3	c-Abl	p53	25	7157	Gene	Gene	tyrosine|amod|START_ENTITY suppression|nmod|tyrosine suppression|nummod|END_ENTITY	p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase .
10391249	0	c-Abl	20,25	p73	36,39	c-Abl	p73	11350(Tax:10090)	22062(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage .
10391251	0	c-Abl	36,41	p73	0,3	c-Abl	p73	25	7161	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage .
12716888	0	c-Abl	13,18	p73	50,53	c-Abl	p73	25	7161	Gene	Gene	Exclusion|nmod|START_ENTITY restrains|nsubj|Exclusion restrains|dobj|function function|amod|END_ENTITY	Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function .
12810679	0	c-Abl	0,5	p73	17,20	c-Abl	p73	25	7161	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	c-Abl stabilizes p73 by a phosphorylation-augmented interaction .
12824179	0	c-Abl	0,5	p73	44,47	c-Abl	p73	25	7161	Gene	Gene	kinase|amod|START_ENTITY regulates|nsubj|kinase regulates|dobj|association association|nummod|END_ENTITY	c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association .
15175157	0	c-Abl	29,34	p73	58,61	c-Abl	p73	25	7161	Gene	Gene	activities|nmod|START_ENTITY links|dobj|activities links|advcl|regulating regulating|dobj|function function|amod|END_ENTITY	Pin1 links the activities of c-Abl and p300 in regulating p73 function .
19897486	0	c-Abl-protein_kinase_Cdelta	23,50	PKCdelta	52,60	c-Abl-protein kinase Cdelta	PKCdelta	5580	5580	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Claudin-1 acts through c-Abl-protein_kinase_Cdelta -LRB- PKCdelta -RRB- signaling and has a causal role in the acquisition of invasive capacity in human liver cells .
21904853	0	c-CBL	29,34	JAK2	44,48	c-CBL	JAK2	867	3717	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	TET2 , ASXL1 , IDH1 , IDH2 , and c-CBL genes in JAK2 - and MPL-negative myeloproliferative_neoplasms .
18974118	0	c-Cbl	0,5	CD38	21,25	c-Cbl	CD38	867	952	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	c-Cbl interacts with CD38 and promotes retinoic_acid-induced differentiation and G0 arrest of human myeloblastic_leukemia cells .
19635790	0	c-Cbl	0,5	CD38	90,94	c-Cbl	CD38	867	952	Gene	Gene	G306E|amod|START_ENTITY abolishes|nsubj|G306E abolishes|nmod|END_ENTITY	c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic_acid-induced cell differentiation and G0 arrest .
19635790	0	c-Cbl	79,84	CD38	90,94	c-Cbl	CD38	867	952	Gene	Gene	interaction|nmod|START_ENTITY abolishes|dobj|interaction abolishes|nmod|END_ENTITY	c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic_acid-induced cell differentiation and G0 arrest .
12794130	0	c-Cbl	18,23	Ephrin-A1	0,9	c-Cbl	Ephrin-A1	867	1942	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells .
12063263	0	c-Cbl	84,89	Epidermal_growth_factor_receptor	0,32	c-Cbl	Epidermal growth factor receptor	867	1956	Gene	Gene	down-regulation|amod|START_ENTITY promote|dobj|down-regulation fails|xcomp|promote fails|nsubj|activation activation|amod|END_ENTITY	Epidermal_growth_factor_receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation .
25521828	0	c-Cbl	21,26	Erbin	0,5	c-Cbl	Erbin	12402(Tax:10090)	59079(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Erbin interacts with c-Cbl and promotes tumourigenesis and tumour growth in colorectal_cancer by preventing c-Cbl-mediated ubiquitination and down-regulation of EGFR .
19201892	0	c-Cbl	21,26	FcgammaRIIa	42,53	c-Cbl	FcgammaRIIa	867	2212	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	The ubiquitin ligase c-Cbl down-regulates FcgammaRIIa activation in human neutrophils .
21740303	0	c-Cbl	37,42	Interferon_regulatory_factor-1	0,30	c-Cbl	Interferon regulatory factor-1	867	3659	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Interferon_regulatory_factor-1 binds c-Cbl , enhances mitogen activated protein kinase signaling and promotes retinoic_acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells .
23352614	0	c-Cbl	29,34	PTK6	0,4	c-Cbl	PTK6	867	5753	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation .
9200440	0	c-Cbl	37,42	Vav	18,21	c-Cbl	Vav	12402(Tax:10090)	22324(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells .
10428778	0	c-Cbl	19,24	epidermal_growth_factor_receptor	57,89	c-Cbl	epidermal growth factor receptor	867	1956	Gene	Gene	finger|nmod|START_ENTITY mediates|nsubj|finger mediates|dobj|desensitization desensitization|nmod|END_ENTITY	The RING finger of c-Cbl mediates desensitization of the epidermal_growth_factor_receptor .
10531381	0	c-Cbl	102,107	epidermal_growth_factor_receptor	37,69	c-Cbl	epidermal growth factor receptor	867	1956	Gene	Gene	finger|amod|START_ENTITY interaction|nmod|finger involves|dobj|interaction involves|nsubj|ubiquitination ubiquitination|nmod|END_ENTITY	Ligand-induced ubiquitination of the epidermal_growth_factor_receptor involves the interaction of the c-Cbl RING finger and UbcH7 .
15465819	0	c-Cbl	29,34	epidermal_growth_factor_receptor	46,78	c-Cbl	epidermal growth factor receptor	867	1956	Gene	Gene	activity|nmod|START_ENTITY guides|nsubj|activity guides|dobj|END_ENTITY	Ubiquitin ligase activity of c-Cbl guides the epidermal_growth_factor_receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment .
17695511	0	c-Cbl	104,109	epidermal_growth_factor_receptor	7,39	c-Cbl	epidermal growth factor receptor	867	1956	Gene	Gene	diminished|nmod|START_ENTITY undergoes|nmod|diminished undergoes|nsubj|END_ENTITY	Mutant epidermal_growth_factor_receptor undergoes less protein degradation due to diminished binding to c-Cbl .
18316398	0	c-Cbl	33,38	epidermal_growth_factor_receptor	52,84	c-Cbl	epidermal growth factor receptor	867	1956	Gene	Gene	interplay|nmod|START_ENTITY interplay|nmod|downregulation downregulation|compound|END_ENTITY	A tale of two Cbls : interplay of c-Cbl and Cbl-b in epidermal_growth_factor_receptor downregulation .
19173594	0	c-Cbl	18,23	epidermal_growth_factor_receptor	90,122	c-Cbl	epidermal growth factor receptor	867	1956	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal_growth_factor_receptor .
7592693	0	c-Cbl	39,44	epidermal_growth_factor_receptor	52,84	c-Cbl	epidermal growth factor receptor	867	1956	Gene	Gene	Coupling|nmod|START_ENTITY Coupling|nmod|END_ENTITY	Coupling of the proto-oncogene product c-Cbl to the epidermal_growth_factor_receptor .
14629478	0	c-Cbl	0,5	glycoprotein_VI	50,65	c-Cbl	glycoprotein VI	12402(Tax:10090)	243816(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	c-Cbl negatively regulates platelet activation by glycoprotein_VI .
9447983	0	c-Cbl	24,29	insulin_receptor	49,65	c-Cbl	insulin receptor	867	3643	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	A novel , multifuntional c-Cbl binding protein in insulin_receptor signaling in 3T3-L1 adipocytes .
9414268	0	c-Cbl	0,5	interleukin-4	36,49	c-Cbl	interleukin-4	867	3565	Gene	Gene	tyrosine-phosphorylated|nsubjpass|START_ENTITY tyrosine-phosphorylated|nmod|END_ENTITY	c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3 ' - kinase pathway .
20717917	0	c-Cbl	0,5	matrix_metalloproteinase_2	40,66	c-Cbl	matrix metalloproteinase 2	867	4313	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	c-Cbl regulates glioma_invasion through matrix_metalloproteinase_2 .
15337528	0	c-Cbl	0,5	p75	61,64	c-Cbl	p75	867	11168	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination .
12061819	0	c-Cbl	57,62	phospholipase_C-gamma1	29,51	c-Cbl	phospholipase C-gamma1	12402(Tax:10090)	18803(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	EGF-dependent association of phospholipase_C-gamma1 with c-Cbl .
18403249	0	c-Cbl	0,5	v-Abl	42,47	c-Cbl	v-Abl	867	25	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	c-Cbl facilitates cytoskeletal effects in v-Abl transformed fibroblast through Rac1 - and Rap1-mediated signaling .
24697523	0	c-Cbl_and_ERK	104,117	EZH2	70,74	c-Cbl and ERK	EZH2	867;5594	2146	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	YC-1 inhibits proliferation of breast_cancer cells by down-regulating EZH2 expression via activation of c-Cbl_and_ERK .
8621590	0	c-Crk	27,32	insulin_receptor_substrate-1_and_4PS	49,85	c-Crk	insulin receptor substrate-1 and 4PS	12928(Tax:10090)	16367(Tax:10090)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	The proto-oncogene product c-Crk associates with insulin_receptor_substrate-1_and_4PS .
21841808	0	c-Ets1	68,74	cyclin_D3	23,32	c-Ets1	cyclin D3	2113	896	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Negative regulation of cyclin_D3 expression by transcription factor c-Ets1 in umbilical cord hematopoietic cells .
22345097	0	c-FLIP	38,44	API-1	24,29	c-FLIP	API-1	8837	329	Gene	Gene	degradation|amod|START_ENTITY induces|dobj|degradation induces|nsubj|END_ENTITY	The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition .
10894163	0	c-FLIP	24,30	Casper	16,22	c-FLIP	Casper	12633(Tax:10090)	12633(Tax:10090)	Gene	Gene	Requirement|appos|START_ENTITY Requirement|nmod|END_ENTITY	Requirement for Casper -LRB- c-FLIP -RRB- in regulation of death receptor-induced apoptosis and embryonic development .
19932761	0	c-FLIP	35,41	Cellular_FLICE-inhibitory_protein	0,33	c-FLIP	Cellular FLICE-inhibitory protein	8837	8837	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Cellular_FLICE-inhibitory_protein -LRB- c-FLIP -RRB- signalling : a key regulator of receptor-mediated apoptosis in physiologic context and in cancer .
17804742	0	c-FLIP	113,119	DR5	72,75	c-FLIP	DR5	8837	8795	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|compound|END_ENTITY	Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin .
11925448	0	c-FLIP	57,63	Notch3	0,6	c-FLIP	Notch3	8837	4854	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation .
21508362	0	c-FLIP	43,49	Pigment_epithelial-derived_factor	0,33	c-FLIP	Pigment epithelial-derived factor	8837	5176	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Pigment_epithelial-derived_factor inhibits c-FLIP expression and assists ciglitazone-induced apoptosis in hepatocellular_carcinoma .
12496481	0	c-FLIP	124,130	TRAIL	66,71	c-FLIP	TRAIL	8837	8743	Gene	Gene	expression|amod|START_ENTITY loss|nmod|expression correlates|nmod|loss apoptosis|acl:relcl|correlates END_ENTITY|dobj|apoptosis	Doxorubicin pretreatment sensitizes prostate_cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression .
18209050	0	c-FLIP	101,107	TRAIL	53,58	c-FLIP	TRAIL	8837	8743	Gene	Gene	regulating|dobj|START_ENTITY confers|advcl|regulating confers|nmod|END_ENTITY	Bone marrow_stroma confers resistance to Apo2_ligand / TRAIL in multiple myeloma in part by regulating c-FLIP .
18790747	0	c-FLIP	115,121	TRAIL	35,40	c-FLIP	TRAIL	8837	8743	Gene	Gene	regulation|nmod|START_ENTITY attenuates|nmod|regulation attenuates|dobj|apoptosis apoptosis|amod|END_ENTITY	Interleukin-8 signaling attenuates TRAIL - and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate_cancer cells .
19956887	0	c-FLIP	104,110	TRAIL	71,76	c-FLIP	TRAIL	8837	8743	Gene	Gene	expression|amod|START_ENTITY down-regulation|nmod|expression END_ENTITY|nmod|down-regulation	The sesquiterpene_lactone_eupatolide sensitizes breast_cancer cells to TRAIL through down-regulation of c-FLIP expression .
20706274	0	c-FLIP	120,126	TRAIL	19,24	c-FLIP	TRAIL	8837	8743	Gene	Gene	expression|amod|START_ENTITY suppression|nmod|expression breaks|nmod|suppression breaks|dobj|resistance resistance|amod|END_ENTITY	Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell_leukemia / lymphoma by translational suppression of c-FLIP expression .
21877938	0	c-FLIP	130,136	TRAIL	19,24	c-FLIP	TRAIL	8837	8743	Gene	Gene	DR5|nmod|START_ENTITY up-regulation|nmod|DR5 restores|nmod|up-regulation restores|dobj|pathway pathway|amod|END_ENTITY	Cisplatin restores TRAIL apoptotic pathway in glioblastoma-derived stem cells through up-regulation of DR5 and down-regulation of c-FLIP .
21914219	0	c-FLIP	35,41	TRAIL	136,141	c-FLIP	TRAIL	8837	8743	Gene	Gene	Suppression|nmod|START_ENTITY eliminates|nsubj|Suppression eliminates|ccomp|stem stem|nmod|agent agent|appos|END_ENTITY	Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast_cancer stem cell activity in response to the anti-cancer agent , TRAIL .
21914854	0	c-FLIP	112,118	TRAIL	64,69	c-FLIP	TRAIL	8837	8743	Gene	Gene	degradation|amod|START_ENTITY facilitating|dobj|degradation augment|advcl|facilitating cooperates|xcomp|augment cooperates|nmod|END_ENTITY	The NEDD8-activating enzyme inhibitor , MLN4924 , cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head_and_neck_cancer cells .
22086925	0	c-FLIP	161,167	TRAIL	103,108	c-FLIP	TRAIL	8837	8743	Gene	Gene	protein|amod|START_ENTITY down-regulation|nmod|protein overcome|nmod|down-regulation overcome|dobj|resistance resistance|amod|tumor_necrosis_factor-related_apoptosis-inducing_ligand tumor_necrosis_factor-related_apoptosis-inducing_ligand|dep|END_ENTITY	Wogonin and related natural flavones overcome tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression .
22086925	0	c-FLIP	161,167	TRAIL	197,202	c-FLIP	TRAIL	8837	8743	Gene	Gene	protein|amod|START_ENTITY down-regulation|nmod|protein down-regulation|nmod|expression expression|amod|END_ENTITY	Wogonin and related natural flavones overcome tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression .
22345097	0	c-FLIP	38,44	TRAIL	77,82	c-FLIP	TRAIL	8837	8743	Gene	Gene	degradation|amod|START_ENTITY induces|dobj|degradation induces|nmod|END_ENTITY	The novel Akt inhibitor API-1 induces c-FLIP degradation and synergizes with TRAIL to augment apoptosis independent of Akt inhibition .
22551975	0	c-FLIP	95,101	TRAIL	115,120	c-FLIP	TRAIL	8837	8743	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	Apoptosis induction by SAHA in cutaneous_T-cell_lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling .
23247197	0	c-FLIP	180,186	TRAIL	126,131	c-FLIP	TRAIL	8837	8743	Gene	Gene	DR5|nmod|START_ENTITY induction|nmod|DR5 END_ENTITY|nmod|induction	Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP .
25824746	0	c-FLIP	14,20	TRAIL	100,105	c-FLIP	TRAIL	8837	8743	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of c-FLIP by RNAi Enhances Sensitivity of the Human Osteogenic_Sarcoma Cell Line U2OS to TRAIL - Induced Apoptosis .
26177636	0	c-FLIP	47,53	TRAIL	148,153	c-FLIP	TRAIL	8837	8743	Gene	Gene	eliminates|nsubj|START_ENTITY eliminates|ccomp|stem stem|nmod|agent agent|appos|END_ENTITY	Erratum to : Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast_cancer stem cell activity in response to the anti-cancer agent , TRAIL .
16403915	0	c-FLIP	107,113	Tax	7,10	c-FLIP	Tax	8837	1491938(Tax:11908)	Gene	Gene	induction|nmod|START_ENTITY protects|nmod|induction protects|nsubj|END_ENTITY	HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular_FLICE-inhibitory_protein -LRB- c-FLIP -RRB- .
18073330	0	c-FLIP	59,65	calpain_3	82,91	c-FLIP	calpain 3	8837	825	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain_3 , the protein involved in limb-girdle muscular dystrophy_type_2A .
12110583	0	c-FLIP	0,6	caspase-8	43,52	c-FLIP	caspase-8	8837	841	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activation activation|amod|END_ENTITY	c-FLIP -LRB- L -RRB- is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis .
25594024	0	c-FLIP	0,6	mTORC2	13,19	c-FLIP	mTORC2	8837	74343(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	c-FLIP links mTORC2 to apoptosis .
10777594	0	c-FOS	110,115	serum_response_factor	16,37	c-FOS	serum response factor	2353	6722	Gene	Gene	activity|amod|START_ENTITY inhibition|nmod|activity results|nmod|inhibition results|nsubj|Cleavage Cleavage|nmod|END_ENTITY	Cleavage of the serum_response_factor during death receptor-induced apoptosis results in an inhibition of the c-FOS promoter transcriptional activity .
2845402	0	c-FOS	99,104	serum_response_factor	19,40	c-FOS	serum response factor	2353	6722	Gene	Gene	enhancer|amod|START_ENTITY element|nmod|enhancer binds|nmod|element factor|acl:relcl|binds Phosphorylation|appos|factor Phosphorylation|nmod|END_ENTITY	Phosphorylation of serum_response_factor , a factor that binds to the serum response element of the c-FOS enhancer .
11801735	0	c-Fes	122,127	Angiopoietin_2	0,14	c-Fes	Angiopoietin 2	14159(Tax:10090)	11601(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Angiopoietin_2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn .
17420256	0	c-Fms	86,91	M-CSF	0,5	c-Fms	M-CSF	1436	1435	Gene	Gene	Tyr-559|amod|START_ENTITY complex|nmod|Tyr-559 signaling|xcomp|complex multimeric|dep|signaling 697/721|amod|multimeric recruitment|nmod|697/721 cytoskeleton|nmod|recruitment regulates|dobj|cytoskeleton regulates|nsubj|END_ENTITY	M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559 / 697/721 .
19705931	0	c-Fms	18,23	M-CSF	3,8	c-Fms	M-CSF	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	antibody|compound|START_ENTITY antibody|amod|END_ENTITY	An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice .
10601350	0	c-Fms	93,98	RANK	148,152	c-Fms	RANK	1436	8792	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor_activator_of_nuclear_factor_kappaB -LRB- RANK -RRB- receptors .
16950670	0	c-Fms	10,15	Vav	25,28	c-Fms	Vav	12978(Tax:10090)	22324(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts .
9694732	0	c-Fms	108,113	colony-stimulating_factor-1	62,89	c-Fms	colony-stimulating factor-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Macrophage lineage cells in inflammation : characterization by colony-stimulating_factor-1 -LRB- CSF-1 -RRB- _ receptor -LRB- c-Fms -RRB- , ER-MP58 , and ER-MP20 -LRB- Ly-6C -RRB- expression .
16648572	0	c-Fms	75,80	colony-stimulating_factor-1_receptor	37,73	c-Fms	colony-stimulating factor-1 receptor	1436	1436	Gene	Gene	tyrosine|appos|START_ENTITY tyrosine|amod|END_ENTITY	Inhibition of phosphorylation of the colony-stimulating_factor-1_receptor -LRB- c-Fms -RRB- tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors .
15531295	0	c-Fos	69,74	ATF-2	82,87	c-Fos	ATF-2	14281(Tax:10090)	11909(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Piperine is a potent inhibitor of nuclear factor-kappaB -LRB- NF-kappaB -RRB- , c-Fos , CREB , ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells .
21069729	0	c-Fos	42,47	Activating_transcription_factor_2	0,33	c-Fos	Activating transcription factor 2	14281(Tax:10090)	11909(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Activating_transcription_factor_2 targets c-Fos , but not c-Jun , in growth plate chondrocytes .
17026529	0	c-Fos	111,116	Bcl-2	134,139	c-Fos	Bcl-2	314322(Tax:10116)	24224(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway : involvement of c-Fos in PACAP-induced Bcl-2 expression .
19079363	0	c-Fos	0,5	Bcl-2	84,89	c-Fos	Bcl-2	14281(Tax:10090)	12043(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2 .
23508111	0	c-Fos	121,126	Brain-derived_neurotrophic_factor	0,33	c-Fos	Brain-derived neurotrophic factor	314322(Tax:10116)	24225(Tax:10116)	Gene	Gene	neurons|nmod|START_ENTITY expression|nmod|neurons induces|dobj|expression induces|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor induces matrix_metalloproteinase_9 expression in neurons via the serum_response_factor / c-Fos pathway .
12865128	0	c-Fos	52,57	CA1	102,105	c-Fos	CA1	2353	759	Gene	Gene	expression|amod|START_ENTITY increase|nmod|expression suppresses|dobj|increase suppresses|nmod|region region|compound|END_ENTITY	Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils .
12882314	0	c-Fos	60,65	CA1	89,92	c-Fos	CA1	14281(Tax:10090)	12346(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|hippocampus hippocampus|nummod|END_ENTITY	Memory retrieval after contextual fear conditioning induces c-Fos and JunB expression in CA1 hippocampus .
22285885	0	c-Fos	107,112	CA1	103,106	c-Fos	CA1	314322(Tax:10116)	310218(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Neonatal alcohol exposure and the hippocampus in developing male rats : effects on behaviorally induced CA1 c-Fos expression , CA1 pyramidal cell number , and contextual fear conditioning .
10082837	0	c-Fos	33,38	CART	12,16	c-Fos	CART	314322(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour .
16169531	0	c-Fos	123,128	CCK	111,114	c-Fos	CCK	314322(Tax:10116)	25298(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Strain differences in myenteric neuron number and CCK1 receptor mRNA expression may account for differences in CCK induced c-Fos activation .
15531295	0	c-Fos	69,74	CREB	76,80	c-Fos	CREB	14281(Tax:10090)	12912(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Piperine is a potent inhibitor of nuclear factor-kappaB -LRB- NF-kappaB -RRB- , c-Fos , CREB , ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells .
26493679	0	c-Fos	145,150	CREB	0,4	c-Fos	CREB	2353	1385	Gene	Gene	expression|amod|START_ENTITY connect|nmod|expression connect|nsubj|END_ENTITY	CREB , AP-1 , ternary complex factors and MAP kinases connect transient_receptor_potential_melastatin-3 -LRB- TRPM3 -RRB- channel stimulation with increased c-Fos expression .
9098578	0	c-Fos	141,146	CREB	0,4	c-Fos	CREB	2353	1385	Gene	Gene	induces|dobj|START_ENTITY cholecystokinin|acl:relcl|induces altered|nmod|cholecystokinin altered|nsubjpass|phosphorylation phosphorylation|compound|END_ENTITY	CREB phosphorylation in the nucleus of the solitary tract and parabrachial nucleus is not altered by peripheral cholecystokinin that induces c-Fos .
17018293	0	c-Fos	29,34	ERK5	38,42	c-Fos	ERK5	2353	5598	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Spatiotemporal regulation of c-Fos by ERK5 and the E3_ubiquitin_ligase UBR1 , and its biological role .
12902987	0	c-Fos	32,37	Fos	12,15	c-Fos	Fos	14281(Tax:10090)	14281(Tax:10090)	Gene	Gene	members|appos|START_ENTITY members|amod|END_ENTITY	Role of the Fos family members , c-Fos , Fra-1 and Fra-2 , in the regulation of cell motility .
8864487	0	c-Fos	0,5	Fos-B	93,98	c-Fos	Fos-B	314322(Tax:10116)	100360880	Gene	Gene	expression|amod|START_ENTITY expression|dep|regulation regulation|appos|co-localization co-localization|nmod|END_ENTITY	c-Fos expression in the rat intergeniculate leaflet : photic regulation , co-localization with Fos-B , and cellular identification .
22266344	0	c-Fos	9,14	FosB	26,30	c-Fos	FosB	314322(Tax:10116)	100360880	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubj|expression expression|compound|END_ENTITY	Regional c-Fos and FosB / / \ FosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats .
10655067	0	c-Fos	37,42	Fosl1	0,5	c-Fos	Fosl1	14281(Tax:10090)	14283(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation .
12714357	0	c-Fos	27,32	GLP-1	46,51	c-Fos	GLP-1	314322(Tax:10116)	24952(Tax:10116)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Gastric distension induces c-Fos in medullary GLP-1 / 2-containing neurons .
15955628	0	c-Fos	34,39	Gastrin-releasing_peptide	0,25	c-Fos	Gastrin-releasing peptide	2353	2922	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Gastrin-releasing_peptide induces c-Fos in the hamster suprachiasmatic nucleus .
22474330	0	c-Fos	42,47	IL-2	7,11	c-Fos	IL-2	2353	3558	Gene	Gene	making|nmod|START_ENTITY decision|acl|making decision|compound|END_ENTITY	Stable IL-2 decision making by endogenous c-Fos amounts in peripheral memory T-helper cells .
8757326	0	c-Fos	83,88	IL-2	31,35	c-Fos	IL-2	2353	3558	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|transcription transcription|nmod|gene gene|compound|END_ENTITY	Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos , FosB , and JunB in anergic T helper 1 cells .
11749217	0	c-Fos	76,81	Kip1	90,94	c-Fos	Kip1	2353	1027	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Effects of macromolecular crowding on the intrinsically disordered proteins c-Fos and p27 -LRB- Kip1 -RRB- .
19456245	0	c-Fos	25,30	Neuropeptide_Y	0,14	c-Fos	Neuropeptide Y	314322(Tax:10116)	24604(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Neuropeptide_Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median_nerve_injury .
8581487	0	c-Fos	69,74	Neuropeptide_Y	0,14	c-Fos	Neuropeptide Y	314322(Tax:10116)	24604(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|injection injection|amod|END_ENTITY	Neuropeptide_Y injection into the fourth cerebroventricle stimulates c-Fos expression in the paraventricular nucleus and other nuclei in the forebrain : effect of food consumption .
9478976	0	c-Fos	24,29	Oncostatin_M	0,12	c-Fos	Oncostatin M	14281(Tax:10090)	18413(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Oncostatin_M stimulates c-Fos to bind a transcriptionally responsive AP-1 element within the tissue_inhibitor_of_metalloproteinase-1 promoter .
8660319	0	c-Fos	34,39	PACAP	0,5	c-Fos	PACAP	314322(Tax:10116)	24166(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY stimulates|dobj|transcription stimulates|nsubj|END_ENTITY	PACAP stimulates transcription of c-Fos and c-Jun and activates the AP-1 transcription factor in rat pancreatic_carcinoma cells .
11857447	0	c-Fos	60,65	PDL	99,102	c-Fos	PDL	2353	5133	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Effect of protein kinase inhibitors on the stretch-elicited c-Fos and c-Jun up-regulation in human PDL osteoblast-like cells .
21487009	0	c-Fos	50,55	Rankl	6,11	c-Fos	Rankl	14281(Tax:10090)	21943(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region .
11384965	0	c-Fos	82,87	TRAIL	163,168	c-Fos	TRAIL	2353	8743	Gene	Gene	START_ENTITY|nmod|Fas Fas|appos|END_ENTITY	Fas-associated_death_domain_protein -LRB- FADD -RRB- and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- via a FLICE inhibitory protein -LRB- FLIP -RRB- - regulated pathway .
15885216	0	c-Fos	22,27	Urocortin_2	0,11	c-Fos	Urocortin 2	314322(Tax:10116)	170896(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Urocortin_2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus .
20382145	0	c-Fos	22,27	Urocortin_2	0,11	c-Fos	Urocortin 2	2353	90226	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Urocortin_2 increases c-Fos expression in serotonergic neurons projecting to the ventricular/periventricular system .
23760290	0	c-Fos	19,24	VEGF	53,57	c-Fos	VEGF	2353	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	The proto-oncogene c-Fos transcriptionally regulates VEGF production during peritoneal inflammation .
19596457	0	c-Fos	18,23	c-Fos	46,51	c-Fos	c-Fos	314322(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|receptors receptors|amod|END_ENTITY	The expression of c-Fos and colocalisation of c-Fos and glucocorticoid receptors in brain structures of low and high anxiety rats subjected to extinction trials and re-learning of a conditioned fear response .
19596457	0	c-Fos	46,51	c-Fos	18,23	c-Fos	c-Fos	314322(Tax:10116)	314322(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY expression|nmod|receptors expression|nmod|END_ENTITY	The expression of c-Fos and colocalisation of c-Fos and glucocorticoid receptors in brain structures of low and high anxiety rats subjected to extinction trials and re-learning of a conditioned fear response .
1470918	0	c-Fos	24,29	c-Jun	87,92	c-Fos	c-Jun	2353	3725	Gene	Gene	degradation|nmod|START_ENTITY v-Fos|nsubj|degradation v-Fos|nmod|signal signal|nmod|END_ENTITY	Targeted degradation of c-Fos , but not v-Fos , by a phosphorylation-dependent signal on c-Jun .
21069729	0	c-Fos	42,47	c-Jun	57,62	c-Fos	c-Jun	14281(Tax:10090)	16476(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|dep|END_ENTITY	Activating_transcription_factor_2 targets c-Fos , but not c-Jun , in growth plate chondrocytes .
7565719	0	c-Fos	15,20	c-Jun	61,66	c-Fos	c-Jun	2353	3725	Gene	Gene	Degradation|nmod|START_ENTITY accelerated|nsubjpass|Degradation accelerated|nmod|kinases kinases|compound|END_ENTITY	Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases .
9867253	0	c-Fos	0,5	c-Jun	24,29	c-Fos	c-Jun	2353	3725	Gene	Gene	dimerization|amod|START_ENTITY dimerization|nmod|END_ENTITY	c-Fos dimerization with c-Jun represses c-Jun enhancement of androgen_receptor transactivation .
9867253	0	c-Fos	0,5	c-Jun	40,45	c-Fos	c-Jun	2353	3725	Gene	Gene	dimerization|amod|START_ENTITY represses|nsubj|dimerization represses|dobj|enhancement enhancement|amod|END_ENTITY	c-Fos dimerization with c-Jun represses c-Jun enhancement of androgen_receptor transactivation .
11384965	0	c-Fos	82,87	caspase-8	47,56	c-Fos	caspase-8	2353	841	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Fas-associated_death_domain_protein -LRB- FADD -RRB- and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- via a FLICE inhibitory protein -LRB- FLIP -RRB- - regulated pathway .
18307898	0	c-Fos	94,99	corticotropin-releasing_hormone	61,92	c-Fos	corticotropin-releasing hormone	2353	1392	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	-LSB- Clinical study of the correlation among the levels of human corticotropin-releasing_hormone , c-Fos and connexin-43 at onset of labor -RSB- .
21732357	0	c-Fos	87,92	interleukin-3	55,68	c-Fos	interleukin-3	2353	3562	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-Fos and Id protein expression .
22076613	0	c-Fos	104,109	matrix_metalloproteinase-7	44,70	c-Fos	matrix metalloproteinase-7	2353	4316	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Tissue factor/activated factor VIIa induces matrix_metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon_cancer cell .
16882662	0	c-Fos	82,87	matrix_metalloproteinase_9	22,48	c-Fos	matrix metalloproteinase 9	2353	4318	Gene	Gene	activation|nmod|START_ENTITY increases|nmod|activation increases|dobj|expression expression|amod|END_ENTITY	Fibronectin increases matrix_metalloproteinase_9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol_3-kinase pathways in human lung_carcinoma cells .
21385848	0	c-Fos	13,18	microRNA-155	33,45	c-Fos	microRNA-155	2353	406947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function .
16879472	0	c-Fos	71,76	sigma-1_receptor	21,37	c-Fos	sigma-1 receptor	14281(Tax:10090)	18391(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Propofol acts at the sigma-1_receptor and inhibits pentazocine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices .
9135069	0	c-Fos	2,7	transforming_growth_factor-beta1	135,167	c-Fos	transforming growth factor-beta1	14281(Tax:10090)	21803(Tax:10090)	Gene	Gene	component|amod|START_ENTITY mediates|nsubj|component mediates|advcl|END_ENTITY	A c-Fos - and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming_growth_factor-beta1 .
11127813	0	c-Ha-Ras	26,34	p53	43,46	c-Ha-Ras	p53	15461(Tax:10090)	7157	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Direct transactivation of c-Ha-Ras gene by p53 : evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis .
9733516	0	c-IAP1	58,64	caspase-8	88,97	c-IAP1	caspase-8	329	841	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	NF-kappaB antiapoptosis : induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation .
19234489	0	c-IAP2	29,35	MALT1	36,41	c-IAP2	MALT1	330	10892	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	TRAF2-binding BIR1 domain of c-IAP2 / MALT1 fusion protein is essential for activation of NF-kappaB .
25794160	0	c-JUN	37,42	Cadherin-11	64,75	c-JUN	Cadherin-11	3725	1009	Gene	Gene	Expression|amod|START_ENTITY Expression|compound|END_ENTITY	AP-1 Transcription Factors c-FOS and c-JUN Mediate GnRH-Induced Cadherin-11 Expression and Trophoblast Cell Invasion .
24457077	0	c-JUN	0,5	JNK	25,28	c-JUN	JNK	3725	5599	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	c-JUN N-terminal kinase -LRB- JNK -RRB- is activated and contributes to tumor cell proliferation in classical Hodgkin_lymphoma .
23661244	0	c-JUN	100,105	NANOG	119,124	c-JUN	NANOG	3725	79923	Gene	Gene	protein|amod|START_ENTITY association|nmod|protein determining|dobj|association determining|advcl|END_ENTITY	The streptavidin/biotinylated DNA/protein bound complex protocol for determining the association of c-JUN protein with NANOG promoter .
18823944	0	c-JUN	42,47	SIRT1	51,56	c-JUN	SIRT1	3725	23411	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of transcriptional activity of c-JUN by SIRT1 .
8361625	0	c-JUN	39,44	nerve_growth_factor	48,67	c-JUN	nerve growth factor	3725	4803	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the transcription factor c-JUN by nerve_growth_factor in adult sensory neurons .
26908448	0	c-Jun	140,145	ANXA11	0,6	c-Jun	ANXA11	16476(Tax:10090)	11744(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	ANXA11 regulates the tumorigenesis , lymph node metastasis and 5-fluorouracil sensitivity of murine hepatocarcinoma Hca-P cells by targeting c-Jun .
11399048	0	c-Jun	57,62	AP-1	89,93	c-Jun	AP-1	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Nitric_oxide suppresses IL-8 transcription by inhibiting c-Jun N-terminal kinase-induced AP-1 activation .
15989974	0	c-Jun	12,17	AP-1	25,29	c-Jun	AP-1	3725	3725	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates .
19628677	0	c-Jun	72,77	Angiotensin_II	0,14	c-Jun	Angiotensin II	3725	183	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates KLF5 phosphorylation and its interaction with c-Jun leading to suppression of p21 expression in vascular smooth muscle cells .
24140207	0	c-Jun	23,28	BAG3	0,4	c-Jun	BAG3	3725	9531	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	BAG3 is upregulated by c-Jun and stabilizes JunD .
11044605	0	c-Jun	0,5	BMP-4	23,28	c-Jun	BMP-4	399400(Tax:8355)	397874(Tax:8355)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	c-Jun -LRB- AP-1 -RRB- activates BMP-4 transcription in Xenopus embryos .
23339184	0	c-Jun	58,63	BRCA1	33,38	c-Jun	BRCA1	3725	672	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in premalignant human ovarian surface epithelial cells .
12446786	0	c-Jun	18,23	C/EBPalpha	59,69	c-Jun	C/EBPalpha	16476(Tax:10090)	12606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Downregulation of c-Jun expression by transcription factor C/EBPalpha is critical for granulocytic lineage commitment .
8545107	0	c-Jun	15,20	CBP	33,36	c-Jun	CBP	3725	1387	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Stimulation of c-Jun activity by CBP : c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro .
17715026	0	c-Jun	26,31	COX-2	46,51	c-Jun	COX-2	16476(Tax:10090)	17709(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of phosphorylated c-Jun expression on COX-2 expression in the substantia nigra of MPTP mouse model of subacute Parkinson_disease -RSB- .
26237449	0	c-Jun	26,31	CSN6	0,4	c-Jun	CSN6	3725	10980	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	CSN6 positively regulates c-Jun in a MEKK1-dependent manner .
21996423	0	c-Jun	30,35	Caspase-3	0,9	c-Jun	Caspase-3	3725	836	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Caspase-3 is a target gene of c-Jun : ATF2 heterodimers during apoptosis induced by activity deprivation in cerebellar granule neurons .
21403399	0	c-Jun	30,35	Cop1	0,4	c-Jun	Cop1	16476(Tax:10090)	26374(Tax:10090)	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice .
25260534	0	c-Jun	25,30	DDX21	9,14	c-Jun	DDX21	3725	9188	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast_cancers .
22307329	0	c-Jun	33,38	DYRK2	0,5	c-Jun	DYRK2	3725	8445	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells .
14739464	0	c-Jun	31,36	De-etiolated-1	6,20	c-Jun	De-etiolated-1	3725	55070	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase .
19940138	0	c-Jun	0,5	Egr-1	44,49	c-Jun	Egr-1	100008856(Tax:9986)	100009491(Tax:9986)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	c-Jun regulates shear - and injury-inducible Egr-1 expression , vein graft stenosis after autologous end-to-side transplantation in rabbits , and intimal hyperplasia in human saphenous veins .
16819515	0	c-Jun	61,66	ErbB4	0,5	c-Jun	ErbB4	3725	2066	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	ErbB4 -LRB- JM-b/CYT -1 -RRB- - induced expression and phosphorylation of c-Jun is abrogated by human_papillomavirus_type_16 E5 protein .
17704768	0	c-Jun	64,69	Fbl10	18,23	c-Jun	Fbl10	3725	84678	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun .
22266871	0	c-Jun	38,43	Gli1	14,18	c-Jun	Gli1	3725	2735	Gene	Gene	activation|amod|START_ENTITY results|nmod|activation results|amod|END_ENTITY	Inhibition of Gli1 results in altered c-Jun activation , inhibition of cisplatin-induced upregulation of ERCC1 , XPD and XRCC1 , and inhibition of platinum-DNA adduct repair .
7512956	0	c-Jun	38,43	Insulin	0,7	c-Jun	Insulin	3725	3630	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Insulin stimulates phosphorylation of c-Jun , c-Fos , and Fos-related proteins in cultured adipocytes .
12065326	0	c-Jun	127,132	Insulin-like_growth_factor-1	0,28	c-Jun	Insulin-like growth factor-1	3725	3479	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Insulin-like_growth_factor-1 enhances inflammatory responses in endothelial cells : role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression .
15721365	0	c-Jun	14,19	JNK	41,44	c-Jun	JNK	3725	5599	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Activation of c-Jun NH2-terminal kinase -LRB- JNK -RRB- signaling pathway is essential for the stimulation of hepatitis_C_virus _ -LRB- HCV -RRB- non-structural protein 3 -LRB- NS3 -RRB- - mediated cell growth .
19116455	0	c-Jun	77,82	JNK	65,68	c-Jun	JNK	16476(Tax:10090)	26419(Tax:10090)	Gene	Gene	activated|nmod|START_ENTITY activated|nmod|END_ENTITY	Transcription of the protein_kinase_C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin .
24471892	0	c-Jun	87,92	JNK	69,72	c-Jun	JNK	3725	5599	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Procyanidin induces apoptosis of esophageal_adenocarcinoma cells via JNK activation of c-Jun .
24865582	0	c-Jun	71,76	JNK-1	65,70	c-Jun	JNK-1	3725	5599	Gene	Gene	pathway|amod|START_ENTITY /|dobj|pathway /|nsubj|Upregulation Upregulation|nmod|ovarian_cancer ovarian_cancer|nmod|END_ENTITY	Upregulation of miR-21 in cisplatin resistant ovarian_cancer via JNK-1 / c-Jun pathway .
25541976	0	c-Jun	83,88	JNK-1	77,82	c-Jun	JNK-1	3725	5599	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Correction : Upregulation of miR-21 in Cisplatin_Resistant_Ovarian_Cancer via JNK-1 / c-Jun Pathway .
12040039	0	c-Jun	89,94	JNK1	139,143	c-Jun	JNK1	16476(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediating|dobj|activation activated|xcomp|mediating activated|nmod|presence presence|nmod|activity activity|compound|END_ENTITY	c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 2/3 is specifically activated by stress , mediating c-Jun activation , in the presence of constitutive JNK1 activity in cerebellar neurons .
12376563	0	c-Jun	47,52	JNK1	0,4	c-Jun	JNK1	16476(Tax:10090)	26419(Tax:10090)	Gene	Gene	phosphorylation-dependent|amod|START_ENTITY osteoclastogenesis|nmod|phosphorylation-dependent osteoclastogenesis|nsubj|modulates modulates|compound|END_ENTITY	JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and - independent mechanisms .
15572687	0	c-Jun	109,114	JNK1	35,39	c-Jun	JNK1	16476(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY essential|nmod|activation essential|nsubj|1 1|appos|END_ENTITY	c-Jun_N-terminal_protein_kinase 1 -LRB- JNK1 -RRB- , but not JNK2 , is essential for tumor_necrosis_factor_alpha-induced c-Jun kinase activation and apoptosis .
21604193	0	c-Jun	14,19	JNK1	77,81	c-Jun	JNK1	3725	5599	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1 .
7890669	0	c-Jun	116,121	JNK1	130,134	c-Jun	JNK1	16476(Tax:10090)	26419(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase , JNK1 .
2513128	0	c-Jun	81,86	Jun-B	0,5	c-Jun	Jun-B	3725	3726	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Jun-B differs in its biological properties from , and is a negative regulator of , c-Jun .
8383624	0	c-Jun	18,23	JunB	0,4	c-Jun	JunB	3725	3726	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	JunB differs from c-Jun in its DNA-binding and dimerization domains , and represses c-Jun by formation of inactive heterodimers .
14515274	0	c-Jun	16,21	MEF2C	0,5	c-Jun	MEF2C	16476(Tax:10090)	17260(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells .
14627958	0	c-Jun	23,28	MEK_kinase_1	0,12	c-Jun	MEK kinase 1	16476(Tax:10090)	26401(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	MEK_kinase_1 regulates c-Jun phosphorylation in the control of corneal morphogenesis .
15735724	0	c-Jun	15,20	Mayven	0,6	c-Jun	Mayven	3725	11275	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Mayven induces c-Jun expression and cyclin_D1 activation in breast_cancer cells .
22508041	0	c-Jun	29,34	MiR-155	0,7	c-Jun	MiR-155	3725	406947	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MiR-155 negatively regulates c-Jun expression at the post-transcriptional level in human dermal fibroblasts in vitro : implications in UVA irradiation-induced photoaging .
12729799	0	c-Jun	47,52	Multiprotein_bridging_factor_1	0,30	c-Jun	Multiprotein bridging factor 1	3725	8721	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Multiprotein_bridging_factor_1 cooperates with c-Jun and is necessary for cardiac_hypertrophy in vitro .
9047395	0	c-Jun	0,5	NF-E2	15,20	c-Jun	NF-E2	16476(Tax:10090)	18022(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	c-Jun inhibits NF-E2 transcriptional activity in association with p18/maf in Friend erythroleukemia cells .
10198817	0	c-Jun	31,36	NGF	8,11	c-Jun	NGF	3725	4803	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of NGF in axotomy-induced c-Jun expression in medial septal cholinergic neurons .
25169428	0	c-Jun	91,96	Nrf2	128,132	c-Jun	Nrf2	3725	4780	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression .
16786139	0	c-Jun	21,26	PEA3	0,4	c-Jun	PEA3	3725	2118	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	PEA3 cooperates with c-Jun in regulation of HER2/neu transcription .
7559555	0	c-Jun	71,76	PEA3	7,11	c-Jun	PEA3	3725	2118	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|ERM ERM|appos|subfamily subfamily|compound|END_ENTITY	ERM , a PEA3 subfamily of Ets transcription factors , can cooperate with c-Jun .
22860098	0	c-Jun	49,54	PES1	30,34	c-Jun	PES1	3725	23481	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of PES1 expression by c-Jun in colon_cancer .
16676006	0	c-Jun	0,5	PTEN	51,55	c-Jun	PTEN	3725	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	c-Jun promotes cellular survival by suppression of PTEN .
15334056	0	c-Jun	137,142	Pdcd4	34,39	c-Jun	Pdcd4	3725	27250	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun .
21860413	0	c-Jun	41,46	Rack1	0,5	c-Jun	Rack1	3725	10399	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation .
12554755	0	c-Jun	39,44	Receptor-interacting_protein_140	0,32	c-Jun	Receptor-interacting protein 140	3725	8204	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Receptor-interacting_protein_140 binds c-Jun and inhibits estradiol-induced activator_protein-1 activity by reversing glucocorticoid_receptor-interacting_protein_1 effect .
23741249	0	c-Jun	48,53	RhoA	0,4	c-Jun	RhoA	3725	387	Gene	Gene	pathway|amod|START_ENTITY cells|nmod|pathway invasion|nmod|cells regulates|dobj|invasion regulates|nsubj|END_ENTITY	RhoA regulates invasion of glioma cells via the c-Jun NH2-terminal kinase pathway under hypoxia .
11356008	0	c-Jun	0,5	STAT3	31,36	c-Jun	STAT3	3725	6774	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|END_ENTITY	c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element -LRB- IRE -RRB- .
14707112	0	c-Jun	32,37	Schnurri-3	0,10	c-Jun	Schnurri-3	16476(Tax:10090)	16656(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Schnurri-3 -LRB- KRC -RRB- interacts with c-Jun to regulate the IL-2 gene in T cells .
21106530	0	c-Jun	67,72	TATA-binding_protein	90,110	c-Jun	TATA-binding protein	3725	6908	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding_protein -LRB- TBP -RRB- and Brf1 expression .
14572313	0	c-Jun	19,24	TGFbeta1	0,8	c-Jun	TGFbeta1	3725	7040	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TGFbeta1 activates c-Jun and Erk1 via alphaVbeta6 integrin .
25533502	0	c-Jun	71,76	TNF-a	96,101	c-Jun	TNF-a	3725	7124	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Butein suppresses ICAM-1 expression through the inhibition of IkBa and c-Jun phosphorylation in TNF-a - and PMA-treated HUVECs .
16029216	0	c-Jun	99,104	Tumor_necrosis_factor-alpha	0,27	c-Jun	Tumor necrosis factor-alpha	16476(Tax:10090)	21926(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY decreases|dobj|activation decreases|nsubj|knockout knockout|compound|receptor receptor|amod|END_ENTITY	Tumor_necrosis_factor-alpha receptor 1 -LRB- p55 -RRB- knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons .
10683516	0	c-Jun	73,78	VIP	18,21	c-Jun	VIP	3725	7432	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	The neuropeptides VIP and PACAP inhibit IL-2 transcription by decreasing c-Jun and increasing JunB expression in T cells .
9591784	0	c-Jun	29,34	androgen_receptor	45,62	c-Jun	androgen receptor	3725	367	Gene	Gene	transactivation|amod|START_ENTITY transactivation|compound|END_ENTITY	Identification of domains of c-Jun mediating androgen_receptor transactivation .
16901904	0	c-Jun	35,40	c-Abl	20,25	c-Jun	c-Abl	16476(Tax:10090)	11350(Tax:10090)	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	The tyrosine kinase c-Abl protects c-Jun from ubiquitination-mediated degradation in T cells .
10637231	0	c-Jun	44,49	c-Abl_and_JNK	83,96	c-Jun	c-Abl and JNK	3725	25;5599	Gene	Gene	START_ENTITY|nmod|activator activator|nmod|END_ENTITY	A nuclear tyrosine phosphorylation circuit : c-Jun as an activator and substrate of c-Abl_and_JNK .
1470918	0	c-Jun	87,92	c-Fos	24,29	c-Jun	c-Fos	3725	2353	Gene	Gene	signal|nmod|START_ENTITY v-Fos|nmod|signal v-Fos|nsubj|degradation degradation|nmod|END_ENTITY	Targeted degradation of c-Fos , but not v-Fos , by a phosphorylation-dependent signal on c-Jun .
21069729	0	c-Jun	57,62	c-Fos	42,47	c-Jun	c-Fos	16476(Tax:10090)	14281(Tax:10090)	Gene	Gene	targets|dep|START_ENTITY targets|dobj|END_ENTITY	Activating_transcription_factor_2 targets c-Fos , but not c-Jun , in growth plate chondrocytes .
7565719	0	c-Jun	61,66	c-Fos	15,20	c-Jun	c-Fos	3725	2353	Gene	Gene	kinases|compound|START_ENTITY accelerated|nmod|kinases accelerated|nsubjpass|Degradation Degradation|nmod|END_ENTITY	Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases .
9867253	0	c-Jun	24,29	c-Fos	0,5	c-Jun	c-Fos	3725	2353	Gene	Gene	dimerization|nmod|START_ENTITY dimerization|amod|END_ENTITY	c-Fos dimerization with c-Jun represses c-Jun enhancement of androgen_receptor transactivation .
9867253	0	c-Jun	40,45	c-Fos	0,5	c-Jun	c-Fos	3725	2353	Gene	Gene	enhancement|amod|START_ENTITY represses|dobj|enhancement represses|nsubj|dimerization dimerization|amod|END_ENTITY	c-Fos dimerization with c-Jun represses c-Jun enhancement of androgen_receptor transactivation .
12234410	0	c-Jun	161,166	c-Jun_amino-terminal_kinase	133,160	c-Jun	c-Jun amino-terminal kinase	3725	5599	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Increased expression of phosphorylated c-Jun_amino-terminal_kinase and phosphorylated c-Jun in human cerebral_aneurysms : role of the c-Jun_amino-terminal_kinase / c-Jun pathway in apoptosis of vascular walls .
12234410	0	c-Jun	161,166	c-Jun_amino-terminal_kinase	39,66	c-Jun	c-Jun amino-terminal kinase	3725	5599	Gene	Gene	pathway|amod|START_ENTITY role|nmod|pathway expression|dep|role expression|nmod|END_ENTITY	Increased expression of phosphorylated c-Jun_amino-terminal_kinase and phosphorylated c-Jun in human cerebral_aneurysms : role of the c-Jun_amino-terminal_kinase / c-Jun pathway in apoptosis of vascular walls .
7877994	0	c-Jun	53,58	c-Mil/Raf	62,71	c-Jun	c-Mil/Raf	3725	22882	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction and N-terminal phosphorylation of c-Jun by c-Mil/Raf .
9543137	0	c-Jun	82,87	connexin-43	9,20	c-Jun	connexin-43	3725	2697	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|expression expression|amod|END_ENTITY	Elevated connexin-43 expression in term human myometrium correlates with elevated c-Jun expression and is independent of myometrial estrogen receptors .
15467760	0	c-Jun	140,145	cyclin_D1	115,124	c-Jun	cyclin D1	3725	595	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|nmod|binding	Estrogen-induced proliferation of normal endometrial glandular cells is initiated by transcriptional activation of cyclin_D1 via binding of c-Jun to an AP-1 sequence .
15923621	0	c-Jun	38,43	epidermal_growth_factor_receptor	65,97	c-Jun	epidermal growth factor receptor	3725	1956	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal_growth_factor_receptor expression and cancer cell proliferation .
7759501	0	c-Jun	121,126	interferon-gamma	43,59	c-Jun	interferon-gamma	3725	3458	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun .
19765400	0	c-Jun	0,5	krox-20	7,14	c-Jun	krox-20	3725	1959	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	c-Jun , krox-20 , and integrin_beta4 expression following chronic_nerve_compression injury .
19910471	0	c-Jun	0,5	phosphoinositide-dependent_kinase_1	16,51	c-Jun	phosphoinositide-dependent kinase 1	16476(Tax:10090)	228026(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	c-Jun regulates phosphoinositide-dependent_kinase_1 transcription : implication for Akt and protein kinase C activities and melanoma_tumorigenesis .
9690204	0	c-Jun	17,22	renin	53,58	c-Jun	renin	16476(Tax:10090)	5972	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|compound|END_ENTITY	Possible role of c-Jun in transcription of the mouse renin gene .
15308638	0	c-Jun	114,119	retinoic_acid_receptor_beta	34,61	c-Jun	retinoic acid receptor beta	3725	5915	Gene	Gene	degradation|nmod|START_ENTITY abrogates|nmod|degradation abrogates|nsubj|expression expression|nmod|END_ENTITY	Ectopic expression of nonliganded retinoic_acid_receptor_beta abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells .
24481121	0	c-Jun	51,56	sLZIP	12,17	c-Jun	sLZIP	3725	10488	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nmod|Regulation	The Role of sLZIP in Transcriptional Regulation of c-Jun and Involvement in Migration and Invasion of Cervical_Cancer Cells .
17145782	0	c-Jun	35,40	stem_cell_factor	102,118	c-Jun	stem cell factor	16476(Tax:10090)	17311(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|induction induction|nmod|END_ENTITY	Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem_cell_factor .
18191973	0	c-Jun	179,184	tumor_necrosis_factor-alpha	18,45	c-Jun	tumor necrosis factor-alpha	3725	7124	Gene	Gene	phosphorylation|amod|START_ENTITY suppression|nmod|phosphorylation inhibits|nmod|suppression inhibits|dobj|expressions expressions|amod|END_ENTITY	Ketamine inhibits tumor_necrosis_factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like_receptor_4-mediated c-Jun N-terminal kinase phosphorylation and activator_protein-1 activation .
15378002	0	c-Jun	0,5	vaccinia-related_kinase_1	35,60	c-Jun	vaccinia-related kinase 1	3725	7443	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	c-Jun phosphorylation by the human vaccinia-related_kinase_1 -LRB- VRK1 -RRB- and its cooperation with the N-terminal_kinase_of_c-Jun -LRB- JNK -RRB- .
14654785	0	c-Jun	0,5	vimentin	54,62	c-Jun	vimentin	3725	7431	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	c-Jun and the dominant-negative mutant , TAM67 , induce vimentin gene expression by interacting with the activator Sp1 .
12668975	0	c-Jun-N-terminal_kinase	0,23	cyclin_D1	31,40	c-Jun-N-terminal kinase	cyclin D1	116554(Tax:10116)	58919(Tax:10116)	Gene	Gene	drives|nsubj|START_ENTITY drives|dobj|expression expression|amod|END_ENTITY	c-Jun-N-terminal_kinase drives cyclin_D1 expression and proliferation during liver_regeneration .
27080425	0	c-Jun-NH2-terminal_kinase	21,46	JNK	48,51	c-Jun-NH2-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of spinal c-Jun-NH2-terminal_kinase -LRB- JNK -RRB- improves locomotor activity of spinal cord injured rats .
19859790	0	c-Jun-NH2_terminal_kinase	0,25	cJun	92,96	c-Jun-NH2 terminal kinase	cJun	5599	3725	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	c-Jun-NH2_terminal_kinase -LRB- JNK -RRB- - mediates AP-1 activation by thioredoxin : phosphorylation of cJun , JunB , and Fra-1 .
9933567	0	c-Jun-amino-terminal_kinase_interacting_protein-1	84,133	JIP-1	135,140	c-Jun-amino-terminal kinase interacting protein-1	JIP-1	9479	9479	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization , fine-mapping , and expression of the human islet-brain_1 -LRB- IB1 -RRB- / c-Jun-amino-terminal_kinase_interacting_protein-1 -LRB- JIP-1 -RRB- gene .
9933567	0	c-Jun-amino-terminal_kinase_interacting_protein-1	84,133	islet-brain_1	64,77	c-Jun-amino-terminal kinase interacting protein-1	islet-brain 1	9479	9479	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Genomic organization , fine-mapping , and expression of the human islet-brain_1 -LRB- IB1 -RRB- / c-Jun-amino-terminal_kinase_interacting_protein-1 -LRB- JIP-1 -RRB- gene .
25848832	0	c-Jun_N-Terminal_Kinase	35,58	ATF3	17,21	c-Jun N-Terminal Kinase	ATF3	116554(Tax:10116)	25389(Tax:10116)	Gene	Gene	Pathways|amod|START_ENTITY END_ENTITY|nmod|Pathways	Heroin Activates ATF3 and CytC via c-Jun_N-Terminal_Kinase Pathways to Mediate Neuronal Apoptosis .
24175110	0	c-Jun_N-Terminal_Kinase	157,180	Alpha_1-Antichymotrypsin	0,24	c-Jun N-Terminal Kinase	Alpha 1-Antichymotrypsin	26419(Tax:10090)	12	Gene	Gene	Activation|amod|START_ENTITY Induces|nmod|Activation Induces|nsubj|END_ENTITY	Alpha_1-Antichymotrypsin , an Inflammatory Protein Overexpressed in the Brains of Patients with Alzheimer 's _ Disease , Induces Tau Hyperphosphorylation through c-Jun_N-Terminal_Kinase Activation .
24763745	0	c-Jun_N-Terminal_Kinase	8,31	JNK	33,36	c-Jun N-Terminal Kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	Activation|amod|START_ENTITY Activation|appos|END_ENTITY	Role of c-Jun_N-Terminal_Kinase -LRB- JNK -RRB- Activation in Micturition Reflexes in Cyclophosphamide -LRB- CYP -RRB- - Induced Cystitis in Female Rats .
21779479	0	c-Jun_N-terminal_Kinase_2	0,25	Receptor_Tyrosine_Kinase	45,69	c-Jun N-terminal Kinase 2	Receptor Tyrosine Kinase	26420(Tax:10090)	22174(Tax:10090)	Gene	Gene	Pathways|amod|START_ENTITY Pathways|compound|END_ENTITY	c-Jun_N-terminal_Kinase_2 Regulates Multiple Receptor_Tyrosine_Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis .
26950456	0	c-Jun_N-terminal_kinase	11,34	Activin_A	38,47	c-Jun N-terminal kinase	Activin A	116554(Tax:10116)	29200(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of c-Jun_N-terminal_kinase on Activin_A / Smads signaling in PC12 cell suffered from oxygen-glucose deprivation .
12584727	0	c-Jun_N-terminal_kinase	93,116	Akt	71,74	c-Jun N-terminal kinase	Akt	5599	207	Gene	Gene	kinase|amod|START_ENTITY kinase|compound|kinase END_ENTITY|appos|kinase	Pyrrolidine_dithiocarbamate-induced neuronal cell death is mediated by Akt , casein kinase 2 , c-Jun_N-terminal_kinase , and IkappaB kinase in embryonic hippocampal progenitor cells .
15890643	0	c-Jun_N-terminal_kinase	252,275	Akt	247,250	c-Jun N-terminal kinase	Akt	116554(Tax:10116)	24185(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
18158102	0	c-Jun_N-terminal_kinase	72,95	Angiotensin_II	0,14	c-Jun N-terminal kinase	Angiotensin II	116554(Tax:10116)	24179(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces proliferation of cultured rat astrocytes through c-Jun_N-terminal_kinase .
7565768	0	c-Jun_N-terminal_kinase	58,81	Angiotensin_II	0,14	c-Jun N-terminal kinase	Angiotensin II	116554(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates calcium-dependent activation of c-Jun_N-terminal_kinase .
14733915	0	c-Jun_N-terminal_kinase	51,74	Bcl-2	0,5	c-Jun N-terminal kinase	Bcl-2	5599	596	Gene	Gene	activation|nmod|START_ENTITY extension|nmod|activation enhances|dobj|extension enhances|nsubj|END_ENTITY	Bcl-2 enhances neurite extension via activation of c-Jun_N-terminal_kinase .
16243436	0	c-Jun_N-terminal_kinase	141,164	Bcl-2	107,112	c-Jun N-terminal kinase	Bcl-2	116554(Tax:10116)	24224(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|dimmers dimmers|dep|expression expression|appos|Bax Bax|nmod|END_ENTITY	Brain_ischemia / reperfusion-induced expression of DP5 and its interaction with Bcl-2 , thus freeing Bax from Bcl-2 / Bax dimmers are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
17262823	0	c-Jun_N-terminal_kinase	127,150	Bcl-2	166,171	c-Jun N-terminal kinase	Bcl-2	5599	596	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Pretreatment with low nitric_oxide protects osteoblasts from high nitric_oxide-induced apoptotic insults through regulation of c-Jun_N-terminal_kinase / c-Jun-mediated Bcl-2 gene expression and protein translocation .
19545597	0	c-Jun_N-terminal_kinase	61,84	Bcl-2	19,24	c-Jun N-terminal kinase	Bcl-2	5599	596	Gene	Gene	pathway|amod|START_ENTITY caspase-3|nmod|pathway END_ENTITY|nmod|caspase-3	Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun_N-terminal_kinase pathway in ursolic_acid-induced DU145 cells apoptosis .
14522843	0	c-Jun_N-terminal_kinase	76,99	CB1	54,57	c-Jun N-terminal kinase	CB1	116554(Tax:10116)	25248(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nummod|END_ENTITY	Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun_N-terminal_kinase activation in cultured cortical neurons .
11544297	0	c-Jun_N-terminal_kinase	25,48	CD28	0,4	c-Jun N-terminal kinase	CD28	26419(Tax:10090)	12487(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	CD28 is not required for c-Jun_N-terminal_kinase activation in T cells .
12421945	0	c-Jun_N-terminal_kinase	135,158	CD44	174,178	c-Jun N-terminal kinase	CD44	5599	960	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Differential regulation of CD44 expression by lipopolysaccharide -LRB- LPS -RRB- and TNF-alpha in human monocytic cells : distinct involvement of c-Jun_N-terminal_kinase in LPS-induced CD44 expression .
16157885	0	c-Jun_N-terminal_kinase	19,42	Cdc42GAP	0,8	c-Jun N-terminal kinase	Cdc42GAP	5599	392	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cdc42GAP regulates c-Jun_N-terminal_kinase -LRB- JNK -RRB- - mediated apoptosis and cell number during mammalian perinatal growth .
21859862	0	c-Jun_N-terminal_kinase	0,23	DCP1a	39,44	c-Jun N-terminal kinase	DCP1a	5599	55802	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Jun_N-terminal_kinase phosphorylates DCP1a to control formation of P bodies .
25337654	0	c-Jun_N-terminal_kinase	141,164	Ghrelin	0,7	c-Jun N-terminal kinase	Ghrelin	116554(Tax:10116)	59301(Tax:10116)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Ghrelin protects alveolar macrophages against lipopolysaccharide-induced apoptosis through growth hormone secretagogue receptor 1a-dependent c-Jun_N-terminal_kinase and Wnt/b-catenin signaling and suppresses_lung_inflammation .
17608927	0	c-Jun_N-terminal_kinase	0,23	Gsk3beta	46,54	c-Jun N-terminal kinase	Gsk3beta	5599	2932	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	c-Jun_N-terminal_kinase -LRB- JNK -RRB- cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability .
14557276	0	c-Jun_N-terminal_kinase	50,73	HIP-55	34,40	c-Jun N-terminal kinase	HIP-55	5599	28988	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	The SH3 domain-containing adaptor HIP-55 mediates c-Jun_N-terminal_kinase activation in T cell receptor signaling .
17891170	0	c-Jun_N-terminal_kinase	51,74	Hsp90	21,26	c-Jun N-terminal kinase	Hsp90	5599	3320	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Proapoptotic role of Hsp90 by its interaction with c-Jun_N-terminal_kinase in lipid rafts in edelfosine-mediated antileukemic therapy .
11287640	0	c-Jun_N-terminal_kinase	27,50	JNK	52,55	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	IL-1-induced NFkappa B and c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation diverge at IL-1_receptor-associated_kinase -LRB- IRAK -RRB- .
11846804	0	c-Jun_N-terminal_kinase	28,51	JNK	53,56	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Transient activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- activity by ligation of the tetraspan CD53 antigen in different cell types .
11856743	0	c-Jun_N-terminal_kinase	18,41	JNK	43,46	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling pathway is essential during PBOX-6-induced apoptosis in chronic_myelogenous_leukemia -LRB- CML -RRB- cells .
12879014	0	c-Jun_N-terminal_kinase	28,51	JNK	53,56	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Selective activation of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3 ' - kinase -LRB- PI3K -RRB- pathway is inhibited .
12880208	0	c-Jun_N-terminal_kinase	12,35	JNK	37,40	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of c-Jun_N-terminal_kinase -LRB- JNK -RRB- in Parkinson 's _ disease .
16367930	0	c-Jun_N-terminal_kinase	14,37	JNK	39,42	c-Jun N-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- signalling in experimentally induced gastric_lesions in rats .
17070508	0	c-Jun_N-terminal_kinase	80,103	JNK	105,108	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	IL-2 / IL-18 prevent the down-modulation of NKG2D by TGF-beta in NK cells via the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
17106880	0	c-Jun_N-terminal_kinase	25,48	JNK	50,53	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Oxidative stress-induced c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation in tendon cells upregulates MMP1 mRNA and protein expression .
17959308	0	c-Jun_N-terminal_kinase	64,87	JNK	89,92	c-Jun N-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Expression of FasL and its interaction with Fas are mediated by c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway in 6-OHDA-induced rat model of Parkinson_disease .
18222647	0	c-Jun_N-terminal_kinase	14,37	JNK	39,42	c-Jun N-terminal kinase	JNK	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- by widely used specific p38_MAPK inhibitors SB202190 and SB203580 : a MLK-3-MKK7-dependent mechanism .
18506470	0	c-Jun_N-terminal_kinase	29,52	JNK	54,57	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- in endometrial cells in vivo and in vitro .
19477251	0	c-Jun_N-terminal_kinase	84,107	JNK	109,112	c-Jun N-terminal kinase	JNK	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	1,3-Dinitrobenzene induces apoptosis in TM4 mouse Sertoli cells : Involvement of the c-Jun_N-terminal_kinase -LRB- JNK -RRB- MAPK pathway .
19900593	0	c-Jun_N-terminal_kinase	0,23	JNK	25,28	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling : recent advances and challenges .
20709173	0	c-Jun_N-terminal_kinase	56,79	JNK	81,84	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation by phosphorylation and purification of human c-Jun_N-terminal_kinase -LRB- JNK -RRB- isoforms in milligram amounts .
21162712	0	c-Jun_N-terminal_kinase	33,56	JNK	28,31	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	Characterization|dep|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a novel JNK -LRB- c-Jun_N-terminal_kinase -RRB- inhibitory peptide .
21277902	0	c-Jun_N-terminal_kinase	108,131	JNK	133,136	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	IDO metabolite produced by EBV-transformed B cells inhibits surface expression of NKG2D in NK cells via the c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
22496813	0	c-Jun_N-terminal_kinase	14,37	JNK	39,42	c-Jun N-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- during mitosis in retinal progenitor cells .
22577133	0	c-Jun_N-terminal_kinase	162,185	JNK	187,190	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Lysophosphatidic_acid induces early growth response-1 -LRB- Egr-1 -RRB- protein expression via protein kinase C - regulated extracellular_signal-regulated_kinase -LRB- ERK -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation in vascular smooth muscle cells .
23184940	0	c-Jun_N-terminal_kinase	9,32	JNK	34,37	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Blocking c-Jun_N-terminal_kinase -LRB- JNK -RRB- translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo .
23430246	0	c-Jun_N-terminal_kinase	51,74	JNK	76,79	c-Jun N-terminal kinase	JNK	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	b2 adrenergic receptor , protein kinase A -LRB- PKA -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- signaling pathways mediate tau pathology in Alzheimer_disease models .
23597429	0	c-Jun_N-terminal_kinase	74,97	JNK	99,102	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	TNF-a up-regulates cellular_inhibitor_of_apoptosis_protein_2 -LRB- c-IAP2 -RRB- via c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway in nasopharyngeal_carcinoma .
24825906	0	c-Jun_N-terminal_kinase	65,88	JNK	90,93	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun_N-terminal_kinase -LRB- JNK -RRB- activation .
8647130	0	c-Jun_N-terminal_kinase	109,132	JNK	134,137	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	signal|amod|START_ENTITY signal|appos|END_ENTITY	Sphingomyelin-derived lipids differentially regulate the extracellular_signal-regulated_kinase_2 -LRB- ERK-2 -RRB- and c-Jun_N-terminal_kinase -LRB- JNK -RRB- signal cascades in airway smooth muscle .
9792916	0	c-Jun_N-terminal_kinase	14,37	JNK	39,42	c-Jun N-terminal kinase	JNK	5599	5599	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- by lysophosphatidic_acid in Swiss 3T3 fibroblasts .
14734742	0	c-Jun_N-terminal_kinase	14,37	MEKK-2	41,47	c-Jun N-terminal kinase	MEKK-2	5599	10746	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Regulation of c-Jun_N-terminal_kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid_arthritis .
10805784	0	c-Jun_N-terminal_kinase	40,63	MEK_kinase_1	0,12	c-Jun N-terminal kinase	MEK kinase 1	5599	4214	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	MEK_kinase_1 is critically required for c-Jun_N-terminal_kinase activation by proinflammatory stimuli and growth factor-induced cell migration .
17548476	0	c-Jun_N-terminal_kinase	18,41	MST1	53,57	c-Jun N-terminal kinase	MST1	5599	4485	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Activation of the c-Jun_N-terminal_kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis .
15890643	0	c-Jun_N-terminal_kinase	252,275	MyD88	108,113	c-Jun N-terminal kinase	MyD88	116554(Tax:10116)	301059(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY expression|dep|factor expression|nmod|cells cells|nmod|receptor-associated receptor-associated|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
17762203	0	c-Jun_N-terminal_kinase	50,73	POSH2	18,23	c-Jun N-terminal kinase	POSH2	116554(Tax:10116)	307472(Tax:10116)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Identification of POSH2 , a novel homologue of the c-Jun_N-terminal_kinase scaffold protein POSH .
11912216	0	c-Jun_N-terminal_kinase	27,50	Polycystin-1	0,12	c-Jun N-terminal kinase	Polycystin-1	5599	5310	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Polycystin-1 activation of c-Jun_N-terminal_kinase and AP-1 is mediated by heterotrimeric G proteins .
12842758	0	c-Jun_N-terminal_kinase	92,115	RANTES	70,76	c-Jun N-terminal kinase	RANTES	26419(Tax:10090)	20304(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Ligation of IFN-gamma-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway .
11050083	0	c-Jun_N-terminal_kinase	56,79	Rac1	30,34	c-Jun N-terminal kinase	Rac1	5599	5879	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Implication of a small GTPase Rac1 in the activation of c-Jun_N-terminal_kinase and heat_shock_factor in response to heat_shock .
21084431	0	c-Jun_N-terminal_kinase	25,48	RhoB	16,20	c-Jun N-terminal kinase	RhoB	5599	388	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Upregulation of RhoB via c-Jun_N-terminal_kinase signaling induces apoptosis of the human gastric_carcinoma NUGC-3 cells treated with NSC12618 .
12492400	0	c-Jun_N-terminal_kinase	89,112	Ser-15	151,157	c-Jun N-terminal kinase	Ser-15	26419(Tax:10090)	3190208(Tax:176280)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Low levels of glutathione_peroxidase_1 activity in selenium-deficient mouse liver affect c-Jun_N-terminal_kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis .
10462047	0	c-Jun_N-terminal_kinase	60,83	TGF-beta	0,8	c-Jun N-terminal kinase	TGF-beta	26419(Tax:10090)	21803(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	TGF-beta inhibits lipopolysaccharide-stimulated activity of c-Jun_N-terminal_kinase in mouse macrophages .
15629137	0	c-Jun_N-terminal_kinase	0,23	TNF-alpha	84,93	c-Jun N-terminal kinase	TNF-alpha	5599	7124	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	c-Jun_N-terminal_kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes .
18047469	0	c-Jun_N-terminal_kinase	106,129	TNFalpha	93,101	c-Jun N-terminal kinase	TNFalpha	5599	7124	Gene	Gene	signalling|amod|START_ENTITY END_ENTITY|nmod|signalling	Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFalpha via c-Jun_N-terminal_kinase signalling .
12023963	0	c-Jun_N-terminal_kinase	48,71	TRAF4	15,20	c-Jun N-terminal kinase	TRAF4	5599	9618	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of TRAF4 in oxidative activation of c-Jun_N-terminal_kinase .
11237765	0	c-Jun_N-terminal_kinase	15,38	alpha1B-adrenergic_receptor	83,110	c-Jun N-terminal kinase	alpha1B-adrenergic receptor	5599	147	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of c-Jun_N-terminal_kinase and p38_mitogen-activated_protein_kinase in alpha1B-adrenergic_receptor / Galphaq-induced inhibition of cell proliferation .
11562426	0	c-Jun_N-terminal_kinase	67,90	angiotensin_II	105,119	c-Jun N-terminal kinase	angiotensin II	116554(Tax:10116)	24179(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|cells cells|amod|END_ENTITY	Quercetin inhibits Shc - and phosphatidylinositol 3-kinase-mediated c-Jun_N-terminal_kinase activation by angiotensin_II in cultured rat aortic smooth muscle cells .
15890643	0	c-Jun_N-terminal_kinase	252,275	c-Src	209,214	c-Jun N-terminal kinase	c-Src	116554(Tax:10116)	83805(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
19545597	0	c-Jun_N-terminal_kinase	61,84	caspase-3	43,52	c-Jun N-terminal kinase	caspase-3	5599	836	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun_N-terminal_kinase pathway in ursolic_acid-induced DU145 cells apoptosis .
23597429	0	c-Jun_N-terminal_kinase	74,97	cellular_inhibitor_of_apoptosis_protein_2	19,60	c-Jun N-terminal kinase	cellular inhibitor of apoptosis protein 2	5599	330	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	TNF-a up-regulates cellular_inhibitor_of_apoptosis_protein_2 -LRB- c-IAP2 -RRB- via c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway in nasopharyngeal_carcinoma .
15056716	0	c-Jun_N-terminal_kinase	153,176	cyclin-dependent_kinase_5	178,203	c-Jun N-terminal kinase	cyclin-dependent kinase 5	5599	1020	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun_N-terminal_kinase , cyclin-dependent_kinase_5 , and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 .
15670574	0	c-Jun_N-terminal_kinase	112,135	cytochrome_c	81,93	c-Jun N-terminal kinase	cytochrome c	5599	54205	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Acetoxycycloheximide -LRB- E-73 -RRB- rapidly induces apoptosis mediated by the release of cytochrome_c via activation of c-Jun_N-terminal_kinase .
9446590	0	c-Jun_N-terminal_kinase	27,50	epidermal_growth_factor_receptor	63,95	c-Jun N-terminal kinase	epidermal growth factor receptor	5599	1956	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Constitutive activation of c-Jun_N-terminal_kinase by a mutant epidermal_growth_factor_receptor .
10528214	0	c-Jun_N-terminal_kinase	68,91	extracellular_signal-related_kinase	14,49	c-Jun N-terminal kinase	extracellular signal-related kinase	5599	5594	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	Src-regulated extracellular_signal-related_kinase and Syk-regulated c-Jun_N-terminal_kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells .
15750181	0	c-Jun_N-terminal_kinase	64,87	fibroblast_growth_factor_receptor_4	118,153	c-Jun N-terminal kinase	fibroblast growth factor receptor 4	26419(Tax:10090)	14186(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Independent repression of bile_acid synthesis and activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- by activated hepatocyte fibroblast_growth_factor_receptor_4 -LRB- FGFR4 -RRB- and bile_acids .
10514426	0	c-Jun_N-terminal_kinase	41,64	gadd45	0,6	c-Jun N-terminal kinase	gadd45	26419(Tax:10090)	13197(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	gadd45 is not required for activation of c-Jun_N-terminal_kinase or p38 during acute stress .
9175761	0	c-Jun_N-terminal_kinase	14,37	granulocyte_macrophage-colony_stimulating_factor	47,95	c-Jun N-terminal kinase	granulocyte macrophage-colony stimulating factor	5599	1437	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-Jun_N-terminal_kinase by human granulocyte_macrophage-colony_stimulating_factor in BA/F3 cells .
9278437	0	c-Jun_N-terminal_kinase	87,110	hematopoietic_progenitor_kinase-1	18,51	c-Jun N-terminal kinase	hematopoietic progenitor kinase-1	5599	11184	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of the hematopoietic_progenitor_kinase-1 -LRB- HPK1 -RRB- - dependent , stress-activated c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway by transforming_growth_factor_beta -LRB- TGF-beta -RRB- - activated kinase -LRB- TAK1 -RRB- , a kinase mediator of TGF_beta signal transduction .
24027268	0	c-Jun_N-terminal_kinase	0,23	heterogeneous_nuclear_ribonucleoprotein_K	43,84	c-Jun N-terminal kinase	heterogeneous nuclear ribonucleoprotein K	379876(Tax:8355)	380255(Tax:8355)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	c-Jun_N-terminal_kinase phosphorylation of heterogeneous_nuclear_ribonucleoprotein_K regulates vertebrate axon outgrowth via a posttranscriptional mechanism .
11812653	0	c-Jun_N-terminal_kinase	42,65	mt1	10,13	c-Jun N-terminal kinase	mt1	5599	644314	Gene	Gene	stimulate|dobj|START_ENTITY stimulate|nsubj|END_ENTITY	Melatonin mt1 and MT2 receptors stimulate c-Jun_N-terminal_kinase via pertussis toxin-sensitive and - insensitive G proteins .
17689926	0	c-Jun_N-terminal_kinase	37,60	myostatin	14,23	c-Jun N-terminal kinase	myostatin	26419(Tax:10090)	17700(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of myostatin signaling by c-Jun_N-terminal_kinase in C2C12 cells .
23026374	0	c-Jun_N-terminal_kinase	10,33	p38_MAPK	78,86	c-Jun N-terminal kinase	p38 MAPK	116554(Tax:10116)	81649(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of c-Jun_N-terminal_kinase -LRB- JNK -RRB- / p38_mitogen-activated_protein_kinase -LRB- p38_MAPK -RRB- in morphine-induced tau protein_hyperphosphorylation .
11418138	0	c-Jun_N-terminal_kinase	95,118	pRb	0,3	c-Jun N-terminal kinase	pRb	5599	5925	Gene	Gene	inhibiting|dobj|START_ENTITY suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun_N-terminal_kinase .
15890643	0	c-Jun_N-terminal_kinase	252,275	phosphatidylinositol_3-kinase	216,245	c-Jun N-terminal kinase	phosphatidylinositol 3-kinase	116554(Tax:10116)	298947(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
11306679	0	c-Jun_N-terminal_kinase	34,57	phosphoinositide_3-Kinase	84,109	c-Jun N-terminal kinase	phosphoinositide 3-Kinase	5599	5294	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|END_ENTITY	Zn -LRB- 2 + -RRB- induces stimulation of the c-Jun_N-terminal_kinase signaling pathway through phosphoinositide_3-Kinase .
21840417	0	c-Jun_N-terminal_kinase	50,73	transglutaminase-2	23,41	c-Jun N-terminal kinase	transglutaminase-2	5599	7052	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Novel participation of transglutaminase-2 through c-Jun_N-terminal_kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells .
22583868	0	c-Jun_N-terminal_kinase-2	178,203	Akt	225,228	c-Jun N-terminal kinase-2	Akt	5601	207	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Protective effect of the poly -LRB- ADP-ribose -RRB- polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular_carcinoma cells involves attenuation of c-Jun_N-terminal_kinase-2 and protein_kinase_B / Akt activation .
16989998	0	c-Jun_N-terminal_kinase-3	146,171	JNK3	173,177	c-Jun N-terminal kinase-3	JNK3	5602	5602	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Three-dimensional quantitative structure-activity relationship -LRB- 3 D-QSAR -RRB- and docking studies on -LRB- benzothiazole-2-yl -RRB- acetonitrile derivatives as c-Jun_N-terminal_kinase-3 -LRB- JNK3 -RRB- inhibitors .
24257757	0	c-Jun_N-terminal_kinase_1	17,42	Arrestin-3	0,10	c-Jun N-terminal kinase 1	Arrestin-3	5599	409	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Arrestin-3 binds c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding .
10769693	0	c-Jun_N-terminal_kinase_1	87,112	CPP32	128,133	c-Jun N-terminal kinase 1	CPP32	5599	836	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Enhancement of chemotherapeutic agents induced-apoptosis associated with activation of c-Jun_N-terminal_kinase_1 and caspase_3 -LRB- CPP32 -RRB- in bax-transfected gastric_cancer cells .
11384840	0	c-Jun_N-terminal_kinase_1	14,39	JNK-1	41,46	c-Jun N-terminal kinase 1	JNK-1	5599	5599	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of c-Jun_N-terminal_kinase_1 -LRB- JNK-1 -RRB- after amino_acid deficiency in HeLa cells .
11077051	0	c-Jun_N-terminal_kinase_1	14,39	JNK1	41,45	c-Jun N-terminal kinase 1	JNK1	5599	5599	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells .
16157589	0	c-Jun_N-terminal_kinase_1	48,73	JNK1	75,79	c-Jun N-terminal kinase 1	JNK1	5599	5599	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- inhibits c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation by transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 -LRB- TAK1 -RRB- .
21540183	0	c-Jun_N-terminal_kinase_1	64,89	JNK1	91,95	c-Jun N-terminal kinase 1	JNK1	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Sirtuin_1 -LRB- SIRT1 -RRB- protein degradation in response to persistent c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation contributes to hepatic_steatosis in obesity .
8557665	0	c-Jun_N-terminal_kinase_1	25,50	JNK1	52,56	c-Jun N-terminal kinase 1	JNK1	5599	5599	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Persistent activation of c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- in gamma radiation-induced apoptosis .
19204086	0	c-Jun_N-terminal_kinase_1	0,25	Myt1	41,45	c-Jun N-terminal kinase 1	Myt1	26419(Tax:10090)	17932(Tax:10090)	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Jun_N-terminal_kinase_1 phosphorylates Myt1 to prevent UVA-induced skin_cancer .
21350211	0	c-Jun_N-terminal_kinase_1	49,74	RelA	29,33	c-Jun N-terminal kinase 1	RelA	26419(Tax:10090)	19697(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Disturbed blood flow induces RelA expression via c-Jun_N-terminal_kinase_1 : a novel mode of NF-kB regulation that promotes arterial_inflammation .
16157589	0	c-Jun_N-terminal_kinase_1	48,73	transforming_growth_factor_beta1	95,127	c-Jun N-terminal kinase 1	transforming growth factor beta1	5599	7040	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- inhibits c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation by transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 -LRB- TAK1 -RRB- .
19339050	0	c-Jun_N-terminal_kinase_2	0,25	JNK1	81,85	c-Jun N-terminal kinase 2	JNK1	5601	5599	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|nmod|END_ENTITY	c-Jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- antagonizes the signaling of differentiation by JNK1 in human myeloid_leukemia cells resistant to vitamin_D .
21357683	0	c-Jun_N-terminal_kinase_2	0,25	epidermal_growth_factor_substrate_8	65,100	c-Jun N-terminal kinase 2	epidermal growth factor substrate 8	5601	2059	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	c-Jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- enhances cell migration through epidermal_growth_factor_substrate_8 -LRB- EPS8 -RRB- .
22386689	0	c-Jun_N-terminal_kinase_3	31,56	Heat_shock_protein_72	0,21	c-Jun N-terminal kinase 3	Heat shock protein 72	25272(Tax:10116)	24472(Tax:10116)	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Heat_shock_protein_72 inhibits c-Jun_N-terminal_kinase_3 signaling pathway via Akt1 during cerebral_ischemia .
20219637	0	c-Jun_N-terminal_kinase_3	96,121	JNK3	123,127	c-Jun N-terminal kinase 3	JNK3	5602	5602	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Neuroprotection of ethanol against ischemia/reperfusion-induced brain_injury through decreasing c-Jun_N-terminal_kinase_3 -LRB- JNK3 -RRB- activation by enhancing GABA release .
18758060	0	c-Jun_N-terminal_protein_kinase	124,155	JNK	157,160	c-Jun N-terminal protein kinase	JNK	5599	5599	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Differential regulation of the antiapoptotic action of B-cell_lymphoma_2 -LRB- Bcl-2 -RRB- and B-cell_lymphoma extra long -LRB- Bcl-xL -RRB- by c-Jun_N-terminal_protein_kinase -LRB- JNK -RRB- 1-involved pathway in neuroglioma cells .
20219981	0	c-Jun_N-terminal_protein_kinase	19,50	tumor_necrosis_factor-alpha	65,92	c-Jun N-terminal protein kinase	tumor necrosis factor-alpha	5599	7124	Gene	Gene	activation|amod|START_ENTITY prevents|dobj|activation prevents|nmod|END_ENTITY	Exendin-4 prevents c-Jun_N-terminal_protein_kinase activation by tumor_necrosis_factor-alpha -LRB- TNFalpha -RRB- and inhibits TNFalpha-induced apoptosis in insulin-secreting cells .
19996384	0	c-Jun_NH2-terminal_kinase	74,99	IRS-1	130,135	c-Jun NH2-terminal kinase	IRS-1	116554(Tax:10116)	25467(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Exercise maintains euglycemia in association with decreased activation of c-Jun_NH2-terminal_kinase and serine phosphorylation of IRS-1 in the liver of ZDF rats .
16491125	0	c-Jun_NH2-terminal_kinase	108,133	JNK	135,138	c-Jun NH2-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun_NH2-terminal_kinase -LRB- JNK -RRB- pathway .
17225125	0	c-Jun_NH2-terminal_kinase	14,39	JNK	41,44	c-Jun NH2-terminal kinase	JNK	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Activation of c-Jun_NH2-terminal_kinase -LRB- JNK -RRB- pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor .
11302725	0	c-Jun_NH2-terminal_kinase	69,94	SHP-1	99,104	c-Jun NH2-terminal kinase	SHP-1	26419(Tax:10090)	15170(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of angiotensin_II_type_2_receptor on tyrosine kinase Pyk2 and c-Jun_NH2-terminal_kinase via SHP-1 tyrosine phosphatase activity : evidence from vascular-targeted transgenic_mice of AT2_receptor .
10706102	0	c-Jun_NH2-terminal_kinase	65,90	p53	0,3	c-Jun NH2-terminal kinase	p53	26419(Tax:10090)	22060(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	p53 phosphorylation and association with murine_double_minute_2 , c-Jun_NH2-terminal_kinase , p14ARF , and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation .
11322657	0	c-Jun_NH2-terminal_kinase3	4,30	JNK3	32,36	c-Jun NH2-terminal kinase3	JNK3	5602	5602	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The c-Jun_NH2-terminal_kinase3 -LRB- JNK3 -RRB- gene : genomic structure , chromosomal assignment , and loss of expression in brain_tumors .
10487526	0	c-Jun_NH2-terminal_kinase_1	105,132	JNK1	134,138	c-Jun NH2-terminal kinase 1	JNK1	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Induction of apoptosis by dexrazoxane -LRB- ICRF-187 -RRB- through caspases in the absence of c-jun expression and c-Jun_NH2-terminal_kinase_1 -LRB- JNK1 -RRB- activation in VM-26-resistant CEM cells .
17061159	0	c-Jun_NH2-terminal_kinase_1	16,43	JNK1	45,49	c-Jun NH2-terminal kinase 1	JNK1	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Crucial role of c-Jun_NH2-terminal_kinase_1 -LRB- JNK1 -RRB- in cold-restraint stress-induced gastric_lesions in mice .
12234410	0	c-Jun_amino-terminal_kinase	133,160	c-Jun	161,166	c-Jun amino-terminal kinase	c-Jun	5599	3725	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Increased expression of phosphorylated c-Jun_amino-terminal_kinase and phosphorylated c-Jun in human cerebral_aneurysms : role of the c-Jun_amino-terminal_kinase / c-Jun pathway in apoptosis of vascular walls .
12234410	0	c-Jun_amino-terminal_kinase	39,66	c-Jun	161,166	c-Jun amino-terminal kinase	c-Jun	5599	3725	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|pathway pathway|amod|END_ENTITY	Increased expression of phosphorylated c-Jun_amino-terminal_kinase and phosphorylated c-Jun in human cerebral_aneurysms : role of the c-Jun_amino-terminal_kinase / c-Jun pathway in apoptosis of vascular walls .
12234410	0	c-Jun_amino-terminal_kinase	133,160	c-Jun_amino-terminal_kinase	39,66	c-Jun amino-terminal kinase	c-Jun amino-terminal kinase	5599	5599	Gene	Gene	pathway|amod|START_ENTITY role|nmod|pathway expression|dep|role expression|nmod|END_ENTITY	Increased expression of phosphorylated c-Jun_amino-terminal_kinase and phosphorylated c-Jun in human cerebral_aneurysms : role of the c-Jun_amino-terminal_kinase / c-Jun pathway in apoptosis of vascular walls .
12234410	0	c-Jun_amino-terminal_kinase	39,66	c-Jun_amino-terminal_kinase	133,160	c-Jun amino-terminal kinase	c-Jun amino-terminal kinase	5599	5599	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|pathway pathway|amod|END_ENTITY	Increased expression of phosphorylated c-Jun_amino-terminal_kinase and phosphorylated c-Jun in human cerebral_aneurysms : role of the c-Jun_amino-terminal_kinase / c-Jun pathway in apoptosis of vascular walls .
18773087	0	c-Jun_amino_terminal_kinase	35,62	JNK	64,67	c-Jun amino terminal kinase	JNK	26419(Tax:10090)	26419(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A predominant role for parenchymal c-Jun_amino_terminal_kinase -LRB- JNK -RRB- in the regulation of systemic_insulin_sensitivity .
12149148	0	c-Jun_terminal_kinase	126,147	JNK	121,124	c-Jun terminal kinase	JNK	5599	5599	Gene	Gene	activation|dep|START_ENTITY activation|compound|END_ENTITY	An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small_cell_lung_cancer cells via JNK -LRB- c-Jun_terminal_kinase -RRB- activation .
12591275	0	c-KIT	102,107	CD117	118,123	c-KIT	CD117	16590(Tax:10090)	16590(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Granulocyte_colony-stimulating_factor induces the release in the bone marrow of proteases that cleave c-KIT receptor -LRB- CD117 -RRB- from the surface of hematopoietic progenitor cells .
21057563	0	c-KIT	29,34	CD117	36,41	c-KIT	CD117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical study of c-KIT -LRB- CD117 -RRB- expression in renal_cell_carcinoma .
21431918	0	c-KIT	23,28	CD34	29,33	c-KIT	CD34	3815	947	Gene	Gene	precursors|amod|START_ENTITY precursors|compound|END_ENTITY	High susceptibility of c-KIT + CD34 + precursors to prolonged doxorubicin exposure interferes with Langerhans cell differentiation in a human cell line model .
24897507	0	c-KIT	11,16	CD34	129,133	c-KIT	CD34	3815	947	Gene	Gene	mutations|amod|START_ENTITY Activating|dobj|mutations Activating|nsubj|damage damage|nmod|progenitors progenitors|compound|END_ENTITY	Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34 + hematopoietic progenitors .
9207416	0	c-KIT	84,89	CD34	78,82	c-KIT	CD34	3815	947	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|dep|cells	Myelomonoblastic leukaemia cells carrying the PEBP2beta/MYH11 fusion gene are CD34 , c-KIT + immature cells .
9038210	0	c-KIT	109,114	Csk_homologous_kinase	22,43	c-KIT	Csk homologous kinase	3815	4145	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of Csk_homologous_kinase -LRB- CHK -RRB- with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes .
25979172	0	c-KIT	37,42	HOTAIR	20,26	c-KIT	HOTAIR	3815	100124700	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Long non-coding RNA HOTAIR modulates c-KIT expression through sponging miR-193a in acute_myeloid_leukemia .
25766129	0	c-KIT	47,52	KIT	6,9	c-KIT	KIT	3815	3815	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	BRAF , KIT and NRAS mutations and expression of c-KIT , phosphorylated extracellular signal-regulated kinase and phosphorylated AKT in Japanese melanoma patients .
26592659	0	c-KIT	51,56	SCF	46,49	c-KIT	SCF	3815	4254	Gene	Gene	system|amod|START_ENTITY down-regulate|dep|system down-regulate|dep|stem_cell_factor stem_cell_factor|appos|END_ENTITY	Estrogens down-regulate the stem_cell_factor -LRB- SCF -RRB- / c-KIT system in prostate cells : Evidence of antiproliferative and proapoptotic effects .
17855052	0	c-KIT	31,36	Stem_Cell_Factor	115,131	c-KIT	Stem Cell Factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	isoforms|amod|START_ENTITY expressing|dobj|isoforms cells|acl|expressing differ|nsubj|cells differ|nmod|END_ENTITY	Early myeloid cells expressing c-KIT isoforms differ in signal transduction , survival and chemotactic responses to Stem_Cell_Factor .
23375718	0	c-KIT	39,44	c-KIT	46,51	c-KIT	c-KIT	3815	3815	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Evaluation of tyrosine-kinase receptor c-KIT -LRB- c-KIT -RRB- mutations , mRNA and protein expression in canine leukemia : might c-KIT represent a therapeutic target ?
23375718	0	c-KIT	46,51	c-KIT	39,44	c-KIT	c-KIT	3815	3815	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Evaluation of tyrosine-kinase receptor c-KIT -LRB- c-KIT -RRB- mutations , mRNA and protein expression in canine leukemia : might c-KIT represent a therapeutic target ?
12780793	0	c-KIT	27,32	core_binding_factor	55,74	c-KIT	core binding factor	3815	10153	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Incidence and prognosis of c-KIT and FLT3 mutations in core_binding_factor -LRB- CBF -RRB- acute_myeloid_leukaemias .
26592659	0	c-KIT	51,56	stem_cell_factor	28,44	c-KIT	stem cell factor	3815	4254	Gene	Gene	system|amod|START_ENTITY down-regulate|dep|system down-regulate|dep|END_ENTITY	Estrogens down-regulate the stem_cell_factor -LRB- SCF -RRB- / c-KIT system in prostate cells : Evidence of antiproliferative and proapoptotic effects .
8889703	0	c-KIT	14,19	stem_cell_factor	36,52	c-KIT	stem cell factor	3815	4254	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of c-KIT and its ligand , stem_cell_factor , in normal and subfertile human testicular tissue .
17897310	0	c-Kit	39,44	Bone_morphogenetic_protein_4	0,28	c-Kit	Bone morphogenetic protein 4	16590(Tax:10090)	12159(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Bone_morphogenetic_protein_4 modulates c-Kit expression and differentiation potential in murine embryonic aorta-gonad-mesonephros haematopoiesis in vitro .
12683902	0	c-Kit	87,92	CD117	80,85	c-Kit	CD117	3815	3815	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	SYT-SSX2 variant of primary pulmonary synovial_sarcoma with focal expression of CD117 -LRB- c-Kit -RRB- protein and a poor clinical outcome .
14994370	0	c-Kit	0,5	CD117	16,21	c-Kit	CD117	3815	3815	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	c-Kit receptor -LRB- CD117 -RRB- expression on myeloblasts and white blood cell counts in acute_myeloid_leukemia .
19874361	0	c-Kit	0,5	CD117	7,12	c-Kit	CD117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	c-Kit -LRB- CD117 -RRB- expression in classic Kaposi 's _ sarcoma .
7545021	0	c-Kit	125,130	CD34	118,122	c-Kit	CD34	3815	947	Gene	Gene	cells|amod|START_ENTITY +|appos|cells +|compound|END_ENTITY	Expression and physiologic significance of Kit ligand and stem cell tyrosine kinase-1 receptor ligand in normal human CD34 + , c-Kit + marrow cells .
9669840	0	c-Kit	118,123	CD34	73,77	c-Kit	CD34	3815	947	Gene	Gene	levels|nmod|START_ENTITY coexpressing|dobj|levels cells|acl|coexpressing END_ENTITY|dobj|cells	Phenotypic and functional characterization of mobilized peripheral blood CD34 + cells coexpressing different levels of c-Kit .
9827903	0	c-Kit	50,55	CD34	81,85	c-Kit	CD34	3815	947	Gene	Gene	antigens|amod|START_ENTITY antigens|nmod|END_ENTITY	All-trans-retinoic_acid up-regulates CD38 but not c-Kit antigens on human marrow CD34 + cells without recruitment into cell cycle .
11825908	0	c-Kit	123,128	Dok-1	114,119	c-Kit	Dok-1	16590(Tax:10090)	13448(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling .
26682010	0	c-Kit	37,42	Fibroblast_Growth_Factor-9	0,26	c-Kit	Fibroblast Growth Factor-9	16590(Tax:10090)	14180(Tax:10090)	Gene	Gene	Cells|amod|START_ENTITY Activates|dobj|Cells Activates|nsubj|END_ENTITY	Fibroblast_Growth_Factor-9 Activates c-Kit Progenitor Cells and Enhances Angiogenesis in the Infarcted Diabetic Heart .
16439710	0	c-Kit	60,65	Flk-1	67,72	c-Kit	Flk-1	3815	3791	Gene	Gene	+|amod|START_ENTITY circulating|dobj|+ END_ENTITY|dep|circulating	Granulocyte_colony-stimulating_factor-mobilized circulating c-Kit + / Flk-1 + progenitor cells regenerate endothelium and inhibit neointimal hyperplasia after vascular_injury .
15337523	0	c-Kit	67,72	IL-2	91,95	c-Kit	IL-2	3815	3558	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- receptor-betagamma signalling is activated by c-Kit in the absence of IL-2 , or by exogenous IL-2 via JAK3/STAT5 in human_papillomavirus-associated_cervical_cancer .
20200353	0	c-Kit	29,34	IL-33	44,49	c-Kit	IL-33	3815	90865	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells .
8677747	0	c-Kit	39,44	JAK2	0,4	c-Kit	JAK2	3815	3717	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem_cell_factor .
18588518	0	c-Kit	48,53	Lnk	16,19	c-Kit	Lnk	3815	10019	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Adaptor protein Lnk associates with Tyr -LRB- 568 -RRB- in c-Kit .
17038523	0	c-Kit	65,70	Mad2	44,48	c-Kit	Mad2	3815	4085	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Mad2 is required for optimal hematopoiesis : Mad2 associates with c-Kit in MO7e cells .
17493588	0	c-Kit	41,46	SCF	36,39	c-Kit	SCF	3815	4254	Gene	Gene	proliferation|amod|START_ENTITY inhibited|dep|proliferation inhibited|dep|stem_cell_factor stem_cell_factor|appos|END_ENTITY	Chrysin inhibited stem_cell_factor -LRB- SCF -RRB- / c-Kit complex-induced cell proliferation in human myeloid_leukemia cells .
21279973	0	c-Kit	14,19	SCF	35,38	c-Kit	SCF	3815	4254	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of c-Kit and its ligand SCF in primary uveal_melanoma .
7577648	0	c-Kit	11,16	SCF	43,46	c-Kit	SCF	3815	4254	Gene	Gene	expression|amod|START_ENTITY Changes|nmod|expression Changes|nmod|END_ENTITY	Changes in c-Kit expression and effects of SCF during differentiation of human erythroid progenitor cells .
9462703	0	c-Kit	18,23	SCF	48,51	c-Kit	SCF	3815	4254	Gene	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression of the c-Kit receptor and its ligand SCF in non-small-cell_lung_carcinomas .
18334674	0	c-Kit	69,74	Sca-1	62,67	c-Kit	Sca-1	16590(Tax:10090)	20238(Tax:10090)	Gene	Gene	+|amod|START_ENTITY Lin|dep|+ Lin|amod|END_ENTITY	Heparanase regulates retention and proliferation of primitive Sca-1 + / c-Kit + / Lin - cells via modulation of the bone marrow microenvironment .
20304046	0	c-Kit	32,37	Sca-1	39,44	c-Kit	Sca-1	16590(Tax:10090)	20238(Tax:10090)	Gene	Gene	+|amod|START_ENTITY capability|dep|+ END_ENTITY|nsubj|capability	Regeneration capability of Lin - / c-Kit + / Sca-1 + cells with or without radiation exposure for repopulation of peripheral blood in lethally irradiated mice monitored using Ly5 .1 isotype on days 35 , 90 , and 270 after transplantation .
20720596	0	c-Kit	8,13	Sca-1	0,5	c-Kit	Sca-1	16590(Tax:10090)	20238(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY MDS|nsubj|expression END_ENTITY|parataxis|MDS	Sca-1 / c-Kit receptor expression and apoptosis pattern in ENU induced MDS mice .
9885214	0	c-Kit	64,69	Sca-1	71,76	c-Kit	Sca-1	3815	836	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	D3 : a gene induced during myeloid cell differentiation of Linlo c-Kit + Sca-1 -LRB- + -RRB- progenitor cells .
15039213	0	c-Kit	38,43	Src	87,90	c-Kit	Src	3815	6714	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic_cancer .
24284075	0	c-Kit	78,83	Src-like-adaptor_protein	0,24	c-Kit	Src-like-adaptor protein	3815	6503	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Src-like-adaptor_protein -LRB- SLAP -RRB- differentially regulates normal and oncogenic c-Kit signaling .
16213778	0	c-Kit	17,22	Stem_cell_factor	0,16	c-Kit	Stem cell factor	3815	4254	Gene	Gene	interactions|amod|START_ENTITY regulate|nsubj|interactions END_ENTITY|parataxis|regulate	Stem_cell_factor / c-Kit interactions regulate human islet-epithelial cluster proliferation and differentiation .
18372228	0	c-Kit	17,22	Stem_cell_factor	0,16	c-Kit	Stem cell factor	3815	4254	Gene	Gene	signalling|nsubj|START_ENTITY END_ENTITY|parataxis|signalling	Stem_cell_factor / c-Kit signalling in normal and androgenetic_alopecia hair follicles .
20589425	0	c-Kit	17,22	Stem_cell_factor	0,16	c-Kit	Stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY supports|nsubj|signaling END_ENTITY|parataxis|supports	Stem_cell_factor / c-Kit signaling in in vitro cultures supports early mouse embryonic development by accelerating proliferation via a mechanism involving Akt-downstream genes .
20521329	0	c-Kit	24,29	Wnt3a	0,5	c-Kit	Wnt3a	16590(Tax:10090)	22416(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY activates|dobj|cells activates|nsubj|END_ENTITY	Wnt3a activates dormant c-Kit -LRB- - -RRB- bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity .
7684496	0	c-Kit	51,56	hematopoietic_cell_phosphatase	15,45	c-Kit	hematopoietic cell phosphatase	3815	5777	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of hematopoietic_cell_phosphatase with c-Kit after stimulation with c-Kit_ligand .
20531294	0	c-Kit	0,5	insulin	69,76	c-Kit	insulin	3815	3630	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	c-Kit and stem_cell_factor regulate PANC-1 cell differentiation into insulin - and glucagon-producing cells .
15145934	0	c-Kit	26,31	stem_cell_factor	9,25	c-Kit	stem cell factor	3815	4254	Gene	Gene	Roles|dep|START_ENTITY Roles|nmod|END_ENTITY	Roles of stem_cell_factor / c-Kit and effects of Glivec/STI571 in human uveal_melanoma cell tumorigenesis .
15308671	0	c-Kit	154,159	stem_cell_factor	22,38	c-Kit	stem cell factor	3815	4254	Gene	Gene	involves|nmod|START_ENTITY involves|nsubj|growth growth|nmod|END_ENTITY	Synergistic growth of stem_cell_factor and granulocyte_macrophage_colony-stimulating_factor involves kinase-dependent and - independent contributions from c-Kit .
17493588	0	c-Kit	41,46	stem_cell_factor	18,34	c-Kit	stem cell factor	3815	4254	Gene	Gene	proliferation|amod|START_ENTITY inhibited|dep|proliferation inhibited|dep|END_ENTITY	Chrysin inhibited stem_cell_factor -LRB- SCF -RRB- / c-Kit complex-induced cell proliferation in human myeloid_leukemia cells .
18054864	0	c-Kit	39,44	stem_cell_factor	22,38	c-Kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	START_ENTITY|dep|tuning tuning|nmod|END_ENTITY	Nociceptive tuning by stem_cell_factor / c-Kit signaling .
18598300	0	c-Kit	54,59	stem_cell_factor	37,53	c-Kit	stem cell factor	3815	4254	Gene	Gene	START_ENTITY|dep|enhances enhances|nmod|END_ENTITY	Geniposide enhances melanogenesis by stem_cell_factor / c-Kit signalling in norepinephrine-exposed normal human epidermal melanocyte .
24626629	0	c-Kit	78,83	stem_cell_factor	20,36	c-Kit	stem cell factor	3815	4254	Gene	Gene	migration|nmod|START_ENTITY enhances|dobj|migration enhances|nsubj|Co-stimulation Co-stimulation|nmod|END_ENTITY	Co-stimulation with stem_cell_factor and erythropoietin enhances migration of c-Kit expressing cervical cancer cells through the sustained activation of ERK1/2 .
24921944	0	c-Kit	69,74	stem_cell_factor	42,58	c-Kit	stem cell factor	3815	4254	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	A human monoclonal antibody targeting the stem_cell_factor receptor -LRB- c-Kit -RRB- blocks_tumor cell signaling and inhibits tumor growth .
27040393	0	c-Kit	4,9	stem_cell_factor	38,54	c-Kit	Stem Cell Factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	level|amod|START_ENTITY level|acl|induced induced|nmod|END_ENTITY	Low c-Kit expression level induced by stem_cell_factor does not compromise transplantation of hematopoietic stem cells .
7542059	0	c-Kit	12,17	stem_cell_factor	34,50	c-Kit	stem cell factor	3815	4254	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of c-Kit and its ligand , stem_cell_factor , in mast cell apoptosis .
8541720	0	c-Kit	31,36	tyrosinase	42,52	c-Kit	tyrosinase	3815	7299	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Coordinated mRNA expression of c-Kit with tyrosinase and TRP-1 in melanin pigmentation of normal and malignant human melanocytes and transient activation of tyrosinase by Kit/SCF-R .
17266790	0	c-Kit_receptor	15,29	Kit_ligand	4,14	c-Kit receptor	Kit ligand	100861386	100860807	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	The Kit_ligand / c-Kit_receptor system in goat ovaries : gene expression and protein localization .
9421237	0	c-Krox	106,112	biglycan	41,49	c-Krox	biglycan	51043	633	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Functional characterization of the human biglycan 5 ' - flanking DNA and binding of the transcription factor c-Krox .
21352589	0	c-MET	52,57	EGFR	24,28	c-MET	EGFR	4233	1956	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	The association between EGFR variant III , HPV , p16 , c-MET , EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous_cell_carcinoma of the head_and_neck .
18628208	0	c-MET	25,30	Hepatocyte_growth_factor	0,24	c-MET	Hepatocyte growth factor	4233	3082	Gene	Gene	tropism|amod|START_ENTITY unrestricted|nsubj|tropism END_ENTITY|parataxis|unrestricted	Hepatocyte_growth_factor / c-MET axis-mediated tropism of cord blood-derived unrestricted somatic stem cells for neuronal_injury .
23386689	0	c-MET	52,57	Hepatocyte_growth_factor	0,24	c-MET	Hepatocyte growth factor	4233	3082	Gene	Gene	brain_tumors|xcomp|START_ENTITY brain_tumors|nsubj|sensitizes sensitizes|compound|END_ENTITY	Hepatocyte_growth_factor sensitizes brain_tumors to c-MET kinase inhibition .
10558888	0	c-MET	37,42	PPARgamma	0,9	c-MET	PPARgamma	4233	5468	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	PPARgamma inhibits the expression of c-MET in human gastric_cancer cells through the suppression of Ets .
20085644	0	c-MET	125,130	Vascular_endothelial_growth_factor	0,34	c-MET	Vascular endothelial growth factor	4233	7422	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor regulates myeloid_cell_leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate_cancer cells .
24876152	0	c-MET	41,46	hepatocyte_growth_factor	16,40	c-MET	hepatocyte growth factor	4233	3082	Gene	Gene	pathway|amod|START_ENTITY role|dep|pathway role|nmod|END_ENTITY	The role of the hepatocyte_growth_factor / c-MET pathway in pancreatic stellate cell-endothelial cell interactions : antiangiogenic implications in pancreatic_cancer .
25451235	0	c-MET	71,76	hepatocyte_growth_factor	34,58	c-MET	hepatocyte growth factor	4233	3082	Gene	Gene	agonist|amod|START_ENTITY agonist|nsubj|fragment fragment|nmod|END_ENTITY	An engineered dimeric fragment of hepatocyte_growth_factor is a potent c-MET agonist .
8180811	0	c-MET	91,96	hepatocyte_growth_factor	40,64	c-MET	hepatocyte growth factor	4233	3082	Gene	Gene	protein|appos|START_ENTITY protein|amod|Immunohistochemistry Immunohistochemistry|nmod|antibodies antibodies|nmod|END_ENTITY	Immunohistochemistry with antibodies to hepatocyte_growth_factor and its receptor protein -LRB- c-MET -RRB- in human brain tissues .
12582153	0	c-MIR	0,5	MIR1	84,88	c-MIR	MIR1	220972	79187	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	c-MIR , a human E3_ubiquitin_ligase , is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity .
14764528	0	c-MPL	98,103	thrombopoietin	145,159	c-MPL	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|acl:relcl|encodes encodes|nmod|receptor receptor|nmod|END_ENTITY	Familial_essential_thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene , which encodes for the receptor for thrombopoietin .
10766162	0	c-MYB	98,103	Cyclooxygenase-2	0,16	c-MYB	Cyclooxygenase-2	4602	5743	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cyclooxygenase-2 , a colorectal_cancer nonsteroidal anti-inflammatory drug target , is regulated by c-MYB .
21062812	6	c-MYB	909,914	miR-155	930,937	SIAH1	miR-424	6477	494336	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|advcl|END_ENTITY	We show that c-MYB is targeted by miR-155 and miR-424 , that the tumor suppressor SIAH1 is targeted by miR-424 , and that c-SKI is potentially regulated by miR-155 .
21447800	0	c-MYC	0,5	BIN1	17,21	c-MYC	BIN1	4609	274	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	c-MYC suppresses BIN1 to release poly -LRB- ADP-ribose -RRB- _ polymerase_1 : a mechanism by which cancer cells acquire cisplatin resistance .
17822678	0	c-MYC	57,62	DKC1	0,4	c-MYC	DKC1	4609	1736	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	DKC1 is a direct and conserved transcriptional target of c-MYC .
25925205	0	c-MYC	16,21	HAUSP	0,5	c-MYC	HAUSP	4609	7874	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP .
19022255	0	c-MYC	41,46	HSP60	21,26	c-MYC	HSP60	4609	3329	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Direct regulation of HSP60 expression by c-MYC induces transformation .
26517351	0	c-MYC	30,35	MYCBP2	44,50	c-MYC	MYCBP2	4609	23077	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros_dysfunction in adult acute_lymphoblastic_leukemia .
17114293	0	c-MYC	26,31	NOTCH1	0,6	c-MYC	NOTCH1	4609	4851	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth .
24792165	0	c-MYC	84,89	POU5F1	60,66	c-MYC	POU5F1	4609	5460	Gene	Gene	START_ENTITY|nsubj|OCT4 OCT4|appos|END_ENTITY	Engineered zinc-finger transcription factors activate OCT4 -LRB- POU5F1 -RRB- , SOX2 , KLF4 , c-MYC -LRB- MYC -RRB- and miR302/367 .
26850841	0	c-MYC	0,5	Per1	42,46	c-MYC	Per1	4609	5187	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	c-MYC targets the central oscillator gene Per1 and is regulated by the circadian clock at the post-transcriptional level .
11679086	0	c-MYC	15,20	Pick	54,58	c-MYC	Pick	4609	9463	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Phosphorylated c-MYC expression in Alzheimer_disease , Pick 's _ disease , progressive_supranuclear_palsy and corticobasal_degeneration .
26317998	0	c-MYC	60,65	SIRT3	0,5	c-MYC	SIRT3	4609	23410	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	SIRT3 inhibits prostate_cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway .
24792165	0	c-MYC	84,89	SOX2	70,74	c-MYC	SOX2	4609	6657	Gene	Gene	START_ENTITY|nsubj|OCT4 OCT4|appos|END_ENTITY	Engineered zinc-finger transcription factors activate OCT4 -LRB- POU5F1 -RRB- , SOX2 , KLF4 , c-MYC -LRB- MYC -RRB- and miR302/367 .
25904219	0	c-MYC	61,66	SOX2	55,59	c-MYC	SOX2	4609	6657	Gene	Gene	miR-302|compound|START_ENTITY END_ENTITY|appos|miR-302	Downregulation of the Genes Involved in Reprogramming -LRB- SOX2 , c-MYC , miR-302 , miR-145 , and P21 -RRB- in Gastric_Adenocarcinoma .
25000517	0	c-MYC	55,60	hTERT	19,24	c-MYC	hTERT	4609	7015	Gene	Gene	activating|xcomp|START_ENTITY potentiates|advcl|activating potentiates|dobj|expression expression|amod|END_ENTITY	FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast .
11306486	0	c-MYC	72,77	ornithine_decarboxylase	18,41	c-MYC	ornithine decarboxylase	4609	4953	Gene	Gene	expression|amod|START_ENTITY achieve|dobj|expression promoter|xcomp|achieve promoter|nsubj|Use Use|nmod|END_ENTITY	Use of a modified ornithine_decarboxylase promoter to achieve efficient c-MYC - or N-MYC-regulated protein expression .
23029531	0	c-MYC	81,86	p150	42,46	c-MYC	p150	4609	10036	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC .
22830357	0	c-MYC	100,105	p53	92,95	c-MYC	p53	4609	7157	Gene	Gene	down-regulation|amod|START_ENTITY END_ENTITY|nmod|down-regulation	The over-expression of miR-34a fails to block DoHH2 lymphoma cell proliferation by reducing p53 via c-MYC down-regulation .
8274734	0	c-MYC	104,109	p53	19,22	c-MYC	p53	4609	7157	Gene	Gene	proto-oncogenes|amod|START_ENTITY translocations|nmod|proto-oncogenes lymphomas|nmod|translocations lymphomas|nsubj|Alterations Alterations|nmod|gene gene|compound|END_ENTITY	Alterations of the p53 tumor suppressor gene in diffuse large cell lymphomas with translocations of the c-MYC and BCL-2 proto-oncogenes .
19408305	0	c-MYC	22,27	peroxiredoxin_III	41,58	c-MYC	peroxiredoxin III	4609	10935	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Downregulation of the c-MYC target gene , peroxiredoxin_III , contributes to arsenic_trioxide-induced apoptosis in acute_promyelocytic_leukemia .
12479216	0	c-MYC	45,50	telomerase_reverse_transcriptase	61,93	c-MYC	telomerase reverse transcriptase	4609	7015	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	The cationic porphyrin_TMPyP4 down-regulates c-MYC and human telomerase_reverse_transcriptase expression and inhibits tumor growth in vivo .
26069660	0	c-Maf	0,5	ADAMTS-12	37,46	c-Maf	ADAMTS-12	4094	81792	Gene	Gene	Expression|amod|START_ENTITY Expression|compound|END_ENTITY	c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells .
17507085	0	c-Maf	60,65	GM-CSF	14,20	c-Maf	GM-CSF	4094	1437	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of GM-CSF expression by the transcription factor c-Maf .
19098919	0	c-Maf	60,65	ICOS	27,31	c-Maf	ICOS	17132(Tax:10090)	54167(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells .
15749884	0	c-Maf	18,23	IL-10	65,70	c-Maf	IL-10	4094	3586	Gene	Gene	factor|nsubj|START_ENTITY factor|nmod|expression expression|compound|END_ENTITY	The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages .
19414776	0	c-Maf	0,5	IL-10	16,21	c-Maf	IL-10	4094	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	c-Maf regulates IL-10 expression during Th17 polarization .
19570826	0	c-Maf	53,58	IL-27	14,19	c-Maf	IL-27	17132(Tax:10090)	246779(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Cutting edge : IL-27 induces the transcription factor c-Maf , cytokine IL-21 , and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells .
20676095	0	c-Maf	45,50	IL-27	122,127	c-Maf	IL-27	4094	246778	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|promote promote|xcomp|cells cells|acl|induced induced|nmod|END_ENTITY	The aryl_hydrocarbon_receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 .
15832295	0	c-Maf	79,84	IL-4	100,104	c-Maf	IL-4	17132(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Impaired IL-4 production by CD8 + T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter .
15832295	0	c-Maf	79,84	IL-4	9,13	c-Maf	IL-4	17132(Tax:10090)	16189(Tax:10090)	Gene	Gene	defect|nmod|START_ENTITY related|nmod|defect related|nsubjpass|production production|compound|END_ENTITY	Impaired IL-4 production by CD8 + T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter .
19553542	0	c-Maf	90,95	IL-4	115,119	c-Maf	IL-4	17132(Tax:10090)	16189(Tax:10090)	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	SUMO conjugation contributes to immune deviation in nonobese diabetic mice by suppressing c-Maf transactivation of IL-4 .
22798672	0	c-Maf	28,33	IL-4	61,65	c-Maf	IL-4	4094	3565	Gene	Gene	phosphorylation|nmod|START_ENTITY enhances|nsubj|phosphorylation enhances|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Tyrosine phosphorylation of c-Maf enhances the expression of IL-4 gene .
24821970	0	c-Maf	22,27	IL-4	40,44	c-Maf	IL-4	17132(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|expression expression|compound|END_ENTITY	KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4 + T cells .
20067416	0	c-Maf	62,67	MMP-13	36,42	c-Maf	MMP-13	4094	4322	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte .
20676095	0	c-Maf	45,50	aryl_hydrocarbon_receptor	4,29	c-Maf	aryl hydrocarbon receptor	4094	196	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 .
22827438	0	c-Maf	35,40	p53	21,24	c-Maf	p53	17132(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation .
16139245	0	c-Met	38,43	CD151	0,5	c-Met	CD151	4233	977	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	CD151 forms a functional complex with c-Met in human salivary_gland_cancer cells .
10037743	0	c-Met	144,149	CD44	25,29	c-Met	CD44	4233	960	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met .
11073815	0	c-Met	14,19	CD44	62,66	c-Met	CD44	4233	960	Gene	Gene	forms|amod|START_ENTITY forms|nmod|END_ENTITY	Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal_cancer .
12183053	0	c-Met	100,105	CD44	0,4	c-Met	CD44	4233	960	Gene	Gene	protein|amod|START_ENTITY phosphorylation|nmod|protein induces|dobj|phosphorylation induces|nsubj|stimulation stimulation|nummod|END_ENTITY	CD44 stimulation by fragmented hyaluronic_acid induces upregulation and tyrosine phosphorylation of c-Met receptor protein in human chondrosarcoma cells .
17923692	0	c-Met	22,27	CD44	74,78	c-Met	CD44	17295(Tax:10090)	12505(Tax:10090)	Gene	Gene	Haploinsufficiency|nmod|START_ENTITY identifies|nsubj|Haploinsufficiency identifies|dobj|collaboration collaboration|nmod|END_ENTITY	Haploinsufficiency of c-Met in cd44 - / - mice identifies a collaboration of CD44 and c-Met in vivo .
21680714	0	c-Met	0,5	CD44	68,72	c-Met	CD44	17295(Tax:10090)	12505(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|nmod|coreceptor coreceptor|acl|compensate compensate|nmod|loss loss|nmod|END_ENTITY	c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice .
24823486	0	c-Met	14,19	CD44	40,44	c-Met	CD44	4233	960	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal_cancer liver metastasis model .
21680714	0	c-Met	0,5	Cd44	76,80	c-Met	Cd44	17295(Tax:10090)	12505(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|nmod|coreceptor coreceptor|acl|compensate compensate|nmod|mice mice|amod|END_ENTITY	c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice .
26260789	0	c-Met	89,94	EGFR	82,86	c-Met	EGFR	4233	1956	Gene	Gene	Antibody|compound|START_ENTITY Antibody|compound|END_ENTITY	Impact of Cell-Surface_Antigen Expression on Target Engagement and Function of an EGFR x c-Met Bispecific Antibody .
26761634	0	c-Met	42,47	EGFR	35,39	c-Met	EGFR	17295(Tax:10090)	13649(Tax:10090)	Gene	Gene	antibody|amod|START_ENTITY antibody|compound|END_ENTITY	Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody .
24034993	0	c-Met	1,6	HGF	138,141	c-Met	HGF	4233	3082	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	-LSB- c-Met signaling pathway participating in the gefitinib resistance of different gene types of non-small_cell_lung_cancer cells induced by HGF in vitro -RSB- .
24961196	0	c-Met	29,34	Hepatocyte_Growth_Factor	4,28	c-Met	Hepatocyte Growth Factor	24553(Tax:10116)	24446(Tax:10116)	Gene	Gene	Antagonist|amod|START_ENTITY Blocks|nsubj|Antagonist END_ENTITY|parataxis|Blocks	The Hepatocyte_Growth_Factor / c-Met Antagonist , Divalinal-Angiotensin IV , Blocks the Acquisition of Methamphetamine Dependent Conditioned Place Preference in Rats .
25840981	0	c-Met	7,12	Hepatocyte_Growth_Factor	41,65	c-Met	Hepatocyte Growth Factor	4233	3082	Gene	Gene	PET|nmod|START_ENTITY PET|nmod|END_ENTITY	PET of c-Met in cancer with 64Cu-labeled Hepatocyte_Growth_Factor .
25840981	0	c-Met	7,12	Hepatocyte_Growth_Factor	41,65	c-Met	Hepatocyte Growth Factor	4233	3082	Gene	Gene	PET|nmod|START_ENTITY PET|nmod|END_ENTITY	PET of c-Met in cancer with 64Cu-labeled Hepatocyte_Growth_Factor .
11896611	0	c-Met	63,68	Hepatocyte_growth_factor	0,24	c-Met	Hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Hepatocyte_growth_factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic_mice treated with diethylnitrosamine .
15342394	0	c-Met	25,30	Hepatocyte_growth_factor	0,24	c-Met	Hepatocyte growth factor	4233	3082	Gene	Gene	signaling|amod|START_ENTITY promotes|nsubj|signaling END_ENTITY|parataxis|promotes	Hepatocyte_growth_factor / c-Met signaling promotes the progression of experimental human neuroblastomas .
22287599	0	c-Met	25,30	Hepatocyte_growth_factor	0,24	c-Met	Hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY important|nsubj|signalling END_ENTITY|parataxis|important	Hepatocyte_growth_factor / c-Met signalling is important for the selection of transplanted hepatocytes .
23209838	0	c-Met	121,126	Hepatocyte_growth_factor	0,24	c-Met	Hepatocyte growth factor	4233	3082	Gene	Gene	pathway|amod|START_ENTITY increases|nmod|pathway increases|nsubj|END_ENTITY	Hepatocyte_growth_factor increases vascular_endothelial_growth_factor-A production in human synovial fibroblasts through c-Met receptor pathway .
24089510	0	c-Met	25,30	Hepatocyte_growth_factor	0,24	c-Met	Hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY required|nsubjpass|signaling END_ENTITY|parataxis|required	Hepatocyte_growth_factor / c-Met signaling is required for b-cell regeneration .
21680714	0	c-Met	0,5	ICAM-1	15,21	c-Met	ICAM-1	17295(Tax:10090)	15894(Tax:10090)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice .
8806690	0	c-Met	65,70	Interleukin_1	0,13	c-Met	Interleukin 1	17295(Tax:10090)	111343(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin_1 induces an autocrine loop hepatocyte_growth_factor / c-Met in murine Kaposi-like spindle cells .
17621632	0	c-Met	14,19	KAI-1	49,54	c-Met	KAI-1	4233	3732	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of c-Met signaling by the tetraspanin KAI-1 / CD82 affects cancer cell migration .
25492484	0	c-Met	80,85	MiR-335	0,7	c-Met	MiR-335	4233	442904	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-335 inhibits migration of breast_cancer cells through targeting oncoprotein c-Met .
26186594	0	c-Met	77,82	MicroRNA-206	0,12	c-Met	MicroRNA-206	4233	406989	Gene	Gene	Pathway|amod|START_ENTITY Progression|nmod|Pathway Inhibition|nmod|Progression END_ENTITY|dep|Inhibition	MicroRNA-206 : Effective Inhibition of Gastric Cancer Progression through the c-Met Pathway .
16455654	0	c-Met	0,5	Mitf	33,37	c-Met	Mitf	4233	4286	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	c-Met expression is regulated by Mitf in the melanocyte lineage .
12611639	0	c-Met	10,15	PI3K	32,36	c-Met	PI3K	4233	5293	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small_cell_lung_cancer .
26919096	0	c-Met	114,119	PI3k	121,125	c-Met	PI3k	4233	5293	Gene	Gene	Akt/mTOR|amod|START_ENTITY Akt/mTOR|dep|END_ENTITY	MiR-206 inhibits HGF-induced epithelial-mesenchymal transition and angiogenesis in non-small cell lung_cancer via c-Met / PI3k / Akt/mTOR pathway .
17689924	0	c-Met	82,87	PKC_delta	142,151	c-Met	PKC delta	4233	5580	Gene	Gene	START_ENTITY|dep|signaling signaling|nmod|END_ENTITY	Lysophosphatidic_acid modulates c-Met redistribution and hepatocyte_growth_factor / c-Met signaling in human bronchial epithelial cells through PKC_delta and E-cadherin .
18779368	0	c-Met	71,76	STAT3	81,86	c-Met	STAT3	4233	6774	Gene	Gene	START_ENTITY|nmod|accumulation accumulation|compound|END_ENTITY	Receptor trafficking controls weak signal delivery : a strategy used by c-Met for STAT3 nuclear accumulation .
22189792	0	c-Met	45,50	Sema4D	0,6	c-Met	Sema4D	4233	10507	Gene	Gene	activation|amod|START_ENTITY suppresses|dobj|activation suppresses|nsubj|END_ENTITY	Sema4D , the ligand for Plexin_B1 , suppresses c-Met activation and migration and promotes melanocyte survival and growth .
17552361	0	c-Met	21,26	Src	14,17	c-Met	Src	4233	6714	Gene	Gene	overexpression|amod|START_ENTITY END_ENTITY|nmod|overexpression	Activation of Src by c-Met overexpression mediates metastatic properties of colorectal_carcinoma cells .
16051641	0	c-Met	47,52	TrkB	26,30	c-Met	TrkB	4233	4915	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness .
15044054	0	c-Met	28,33	adrenomedullin	10,24	c-Met	adrenomedullin	24553(Tax:10116)	25026(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of adrenomedullin on c-Met receptor expression after reserpine-induced gastric_damage in the rat .
14745610	0	c-Met	0,5	alpha-fetoprotein	57,74	c-Met	alpha-fetoprotein	4233	174	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	c-Met expression in a gastric_cancer cell line producing alpha-fetoprotein .
17283128	0	c-Met	61,66	androgen_receptor	4,21	c-Met	androgen receptor	4233	367	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The androgen_receptor negatively regulates the expression of c-Met : implications for a novel mechanism of prostate_cancer progression .
22261330	0	c-Met	0,5	aquaporin_3	18,29	c-Met	aquaporin 3	4233	360	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	c-Met upregulates aquaporin_3 expression in human gastric_carcinoma cells via the ERK signalling pathway .
19435874	0	c-Met	51,56	c-Met	8,13	c-Met	c-Met	4233	4233	Gene	Gene	phosphorylation|nmod|START_ENTITY inhibit|dobj|phosphorylation inhibit|nsubj|receptors receptors|amod|END_ENTITY	Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte_growth_factor : c-Met-dependent tumors in animal models .
19435874	0	c-Met	8,13	c-Met	51,56	c-Met	c-Met	4233	4233	Gene	Gene	receptors|amod|START_ENTITY inhibit|nsubj|receptors inhibit|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte_growth_factor : c-Met-dependent tumors in animal models .
17923692	0	c-Met	22,27	cd44	31,35	c-Met	cd44	17295(Tax:10090)	12505(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Haploinsufficiency of c-Met in cd44 - / - mice identifies a collaboration of CD44 and c-Met in vivo .
10642827	0	c-Met	70,75	hepatocyte_growth_factor	27,51	c-Met	hepatocyte growth factor	24553(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of hepatocyte_growth_factor and its receptor , c-Met in the rat retina during development .
11328532	0	c-Met	43,48	hepatocyte_growth_factor	18,42	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	pathway|amod|START_ENTITY increased|nsubjpass|pathway Expression|parataxis|increased Expression|nmod|END_ENTITY	Expression of the hepatocyte_growth_factor / c-Met pathway is increased at the cancer front in breast_carcinoma .
11735009	0	c-Met	65,70	hepatocyte_growth_factor	22,46	c-Met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of hepatocyte_growth_factor and its receptor -LRB- c-Met -RRB- during mouse liver development .
14730703	0	c-Met	42,47	hepatocyte_growth_factor	17,41	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	loop|amod|START_ENTITY promotes|nsubj|loop END_ENTITY|parataxis|promotes	CD44-independent hepatocyte_growth_factor / c-Met autocrine loop promotes malignant_peripheral_nerve_sheath_tumor cell invasion in vitro .
15075332	0	c-Met	119,124	hepatocyte_growth_factor	167,191	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	activation|amod|START_ENTITY involves|dobj|activation involves|nmod|END_ENTITY	Bi-directional regulation of Ser-985 phosphorylation of c-met via protein_kinase_C and protein phosphatase_2A involves c-Met activation and cellular responsiveness to hepatocyte_growth_factor .
15288476	0	c-Met	67,72	hepatocyte_growth_factor	32,56	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	SU5416 is a potent inhibitor of hepatocyte_growth_factor receptor -LRB- c-Met -RRB- and blocks HGF-induced invasiveness of human HepG2 hepatoma cells .
15842800	0	c-Met	40,45	hepatocyte_growth_factor	15,39	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	system|amod|START_ENTITY Expression|dep|system Expression|nmod|END_ENTITY	-LSB- Expression of hepatocyte_growth_factor / c-Met system in nasopharyngeal_carcinoma and its biological significance -RSB- .
16998831	0	c-Met	136,141	hepatocyte_growth_factor	111,135	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|invasiveness invasiveness|nmod|cells cells|nmod|END_ENTITY	Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic_cancer cells through the hepatocyte_growth_factor / c-Met pathway .
17534684	0	c-Met	146,151	hepatocyte_growth_factor	121,145	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	START_ENTITY|dep|accelerates accelerates|dobj|progression progression|nmod|activation activation|nmod|END_ENTITY	The hypoxic environment in tumor-stromal cells accelerates pancreatic_cancer progression via the activation of paracrine hepatocyte_growth_factor / c-Met signaling .
17942915	0	c-Met	33,38	hepatocyte_growth_factor	8,32	c-Met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY accelerates|nsubj|signaling Loss|parataxis|accelerates Loss|nmod|END_ENTITY	Loss of hepatocyte_growth_factor / c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis .
17992475	0	c-Met	33,38	hepatocyte_growth_factor	8,32	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	signaling|nsubj|START_ENTITY Role|parataxis|signaling Role|nmod|END_ENTITY	Role of hepatocyte_growth_factor / c-Met signaling in regulating urokinase plasminogen activator on invasiveness_in_human_hepatocellular_carcinoma : a potential therapeutic target .
18422749	0	c-Met	117,122	hepatocyte_growth_factor	13,37	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	system|amod|START_ENTITY factor-1|dep|system activates|parataxis|factor-1 activates|nsubj|Induction Induction|nmod|expression expression|compound|END_ENTITY	Induction of hepatocyte_growth_factor activator gene expression under hypoxia activates the hepatocyte_growth_factor / c-Met system via hypoxia inducible factor-1 in pancreatic_cancer .
18422749	0	c-Met	117,122	hepatocyte_growth_factor	92,116	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	system|amod|START_ENTITY factor-1|dep|system activates|parataxis|factor-1 activates|dobj|END_ENTITY	Induction of hepatocyte_growth_factor activator gene expression under hypoxia activates the hepatocyte_growth_factor / c-Met system via hypoxia inducible factor-1 in pancreatic_cancer .
19123972	0	c-Met	29,34	hepatocyte_growth_factor	4,28	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	The hepatocyte_growth_factor / c-Met signaling pathway as a therapeutic target to inhibit angiogenesis .
19435874	0	c-Met	51,56	hepatocyte_growth_factor	71,95	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte_growth_factor : c-Met-dependent tumors in animal models .
19435874	0	c-Met	8,13	hepatocyte_growth_factor	71,95	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	receptors|amod|START_ENTITY inhibit|nsubj|receptors inhibit|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte_growth_factor : c-Met-dependent tumors in animal models .
19713535	0	c-Met	44,49	hepatocyte_growth_factor	19,43	c-Met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	system|amod|START_ENTITY action|dep|system action|nmod|END_ENTITY	Negative action of hepatocyte_growth_factor / c-Met system on angiotensin_II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells .
20086056	0	c-Met	116,121	hepatocyte_growth_factor	91,115	c-Met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY Nle-Tyr-Leu-psi|dobj|inhibitor Nle-Tyr-Leu-psi|parataxis|act act|nmod|END_ENTITY	The angiotensin_IV analog Nle-Tyr-Leu-psi - -LRB- CH2-NH2 -RRB- 3-4-His-Pro-Phe -LRB- norleual -RRB- can act as a hepatocyte_growth_factor / c-Met inhibitor .
20178463	0	c-Met	30,35	hepatocyte_growth_factor	5,29	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	signal|amod|START_ENTITY signal|compound|END_ENTITY	Does hepatocyte_growth_factor / c-Met signal play synergetic role in lung_cancer ?
20819464	0	c-Met	37,42	hepatocyte_growth_factor	12,36	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of hepatocyte_growth_factor / c-Met in chronic rhinosinusitis with nasal_polyps .
20980460	0	c-Met	39,44	hepatocyte_growth_factor	14,38	c-Met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY enhances|nsubj|signaling Disruption|parataxis|enhances Disruption|nmod|END_ENTITY	Disruption of hepatocyte_growth_factor / c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes .
21150524	0	c-Met	37,42	hepatocyte_growth_factor	12,36	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	system|amod|START_ENTITY role|dep|system role|nmod|END_ENTITY	The role of hepatocyte_growth_factor / c-Met system in keloid pathogenesis .
21796631	0	c-Met	136,141	hepatocyte_growth_factor	111,135	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	START_ENTITY|dep|predicts predicts|dobj|dissemination dissemination|acl|established established|nmod|END_ENTITY	Co-expression of hepatocyte_growth_factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte_growth_factor / c-Met signaling in gastric_cancer .
21796631	0	c-Met	136,141	hepatocyte_growth_factor	17,41	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	START_ENTITY|dep|predicts predicts|nsubj|Co-expression Co-expression|nmod|END_ENTITY	Co-expression of hepatocyte_growth_factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte_growth_factor / c-Met signaling in gastric_cancer .
22996389	0	c-Met	16,21	hepatocyte_growth_factor	80,104	c-Met	hepatocyte growth factor	4233	15234(Tax:10090)	Gene	Gene	sites|amod|START_ENTITY sites|nmod|cells cells|nmod|response response|nmod|END_ENTITY	Dissociation of c-Met phosphotyrosine sites in human cells in response to mouse hepatocyte_growth_factor but not human hepatocyte_growth_factor : the possible roles of different amino_acids in different species .
24609899	0	c-Met	46,51	hepatocyte_growth_factor	21,45	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	miR-199a-3p inhibits hepatocyte_growth_factor / c-Met signaling in renal_cancer_carcinoma .
24748602	0	c-Met	110,115	hepatocyte_growth_factor	85,109	c-Met	hepatocyte growth factor	4233	24446(Tax:10116)	Gene	Gene	START_ENTITY|dep|fibroblasts fibroblasts|xcomp|accelerate accelerate|nmod|END_ENTITY	Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte_growth_factor / c-Met signaling .
24810547	0	c-Met	70,75	hepatocyte_growth_factor	9,33	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	gene|amod|START_ENTITY overexpression|nmod|gene overexpression|compound|END_ENTITY	Frequent hepatocyte_growth_factor overexpression and low frequency of c-Met gene amplification in human_papillomavirus-negative tonsillar_squamous_cell_carcinoma and their prognostic significances .
25592281	0	c-Met	50,55	hepatocyte_growth_factor	25,49	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	expression|amod|START_ENTITY significance|dep|expression significance|nmod|END_ENTITY	Clinical significance of hepatocyte_growth_factor / c-Met expression in the assessment of gastric_cancer progression .
9184586	0	c-Met	48,53	hepatocyte_growth_factor	23,47	c-Met	hepatocyte growth factor	24553(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of hepatocyte_growth_factor / c-Met by myocardial_ischemia and reperfusion in a rat model .
9600310	0	c-Met	27,32	hepatocyte_growth_factor	49,73	c-Met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|receptor receptor|nmod|END_ENTITY	Expression and function of c-Met , a receptor for hepatocyte_growth_factor , during T-cell development .
9722511	0	c-Met	86,91	hepatocyte_growth_factor	58,82	c-Met	hepatocyte growth factor	4233	3082	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Cooperative interaction between alpha - and beta-chains of hepatocyte_growth_factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses .
26325180	0	c-Met	19,24	microRNA-206	37,49	c-Met	microRNA-206	4233	406989	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of c-Met and Bcl2 by microRNA-206 , activates apoptosis , and inhibits tumor cell proliferation , migration and colony formation .
11438654	0	c-Met	84,89	scatter_factor	68,82	c-Met	scatter factor	403438(Tax:9615)	403441(Tax:9615)	Gene	Gene	factor|dep|START_ENTITY factor|appos|END_ENTITY	The multisubstrate adapter Gab1 regulates hepatocyte growth factor -LRB- scatter_factor -RRB- - c-Met signaling for cell survival and DNA repair .
7515877	0	c-Met	79,84	scatter_factor	95,109	c-Met	scatter factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor -LRB- scatter_factor / hepatocyte growth factor receptor -RRB- .
7689722	0	c-Met	139,144	scatter_factor	48,62	c-Met	scatter factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY domain|nmod|receptor mediated|nmod|domain dissociation|parataxis|mediated dissociation|acl|triggered triggered|nmod|END_ENTITY	The cell dissociation and motility triggered by scatter_factor / hepatocyte_growth_factor are mediated through the cytoplasmic domain of the c-Met receptor .
7877994	0	c-Mil/Raf	62,71	c-Jun	53,58	c-Mil/Raf	c-Jun	22882	3725	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction and N-terminal phosphorylation of c-Jun by c-Mil/Raf .
10747020	0	c-Mos	22,27	Hsp90	0,5	c-Mos	Hsp90	397924(Tax:8355)	444024(Tax:8355)	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes .
9663467	0	c-Mpl	85,90	Thrombopoietin	0,14	c-Mpl	Thrombopoietin	4352	7066	Gene	Gene	differentiation|nmod|START_ENTITY supports|nmod|differentiation supports|nsubj|END_ENTITY	Thrombopoietin supports in vitro erythroid differentiation via its specific receptor c-Mpl in a human leukemia cell line .
7542117	0	c-Mpl	86,91	megakaryocyte_growth_and_development_factor	18,61	c-Mpl	megakaryocyte growth and development factor	4352	7066	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Recombinant human megakaryocyte_growth_and_development_factor -LRB- rHuMGDF -RRB- , a ligand for c-Mpl , produces functional human platelets in vitro .
10554816	0	c-Mpl	59,64	thrombopoietin	34,48	c-Mpl	thrombopoietin	4352	7066	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Human dendritic cells express the thrombopoietin receptor , c-Mpl .
10611229	0	c-Mpl	31,36	thrombopoietin	95,109	c-Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY half|nmod|domain Role|nmod|half Role|nmod|production production|nmod|END_ENTITY	Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo .
10918061	0	c-Mpl	98,103	thrombopoietin	73,87	c-Mpl	thrombopoietin	4352	7066	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor , c-Mpl .
11012212	0	c-Mpl	15,20	thrombopoietin	21,35	c-Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation .
12068799	0	c-Mpl	81,86	thrombopoietin	34,48	c-Mpl	thrombopoietin	4352	7066	Gene	Gene	measurement|nmod|START_ENTITY measurement|nmod|END_ENTITY	Simultaneous measurement of serum thrombopoietin and expression of megakaryocyte c-Mpl with clinical and laboratory correlates for myelofibrosis_with_myeloid_metaplasia .
15531462	0	c-Mpl	80,85	thrombopoietin	9,23	c-Mpl	thrombopoietin	4352	7066	Gene	Gene	receptor|appos|START_ENTITY sequence|nmod|receptor levels|nmod|sequence levels|compound|END_ENTITY	Elevated thrombopoietin levels and alterations in the sequence of its receptor , c-Mpl , in patients with Diamond-Blackfan_anemia .
16480521	0	c-Mpl	29,34	thrombopoietin	4,18	c-Mpl	thrombopoietin	4352	7066	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The thrombopoietin receptor , c-Mpl , is a selective surface marker for human hematopoietic stem cells .
18726378	0	c-Mpl	71,76	thrombopoietin	47,61	c-Mpl	thrombopoietin	4352	7066	Gene	Gene	START_ENTITY|nsubj|Screening Screening|nmod|proteins proteins|acl:relcl|interact interact|nmod|receptor receptor|compound|END_ENTITY	Screening of proteins that interact with human thrombopoietin receptor c-Mpl using yeast two-hybrid system .
25468569	0	c-Mpl	107,112	thrombopoietin	23,37	c-Mpl	thrombopoietin	4352	7066	Gene	Gene	splicing|nmod|START_ENTITY regulates|nmod|splicing regulates|dobj|response response|compound|END_ENTITY	Ott1 -LRB- Rbm15 -RRB- regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl .
7862460	0	c-Mpl	65,70	thrombopoietin	87,101	c-Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Structure and transcription of the genomic locus encoding murine c-Mpl , a receptor for thrombopoietin .
9448308	0	c-Mpl	53,58	thrombopoietin	77,91	c-Mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Hematopoietic stem cell deficiencies in mice lacking c-Mpl , the receptor for thrombopoietin .
9401284	0	c-Mpl_ligand	26,38	thrombopoietin	10,24	c-Mpl ligand	thrombopoietin	7066	7066	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of thrombopoietin -LRB- c-Mpl_ligand -RRB- alone and in combination with other hematopoietic growth factors on human megakaryocytopoiesis in serum-free cultures .
10644988	0	c-Myb	26,31	CBP	76,79	c-Myb	CBP	4602	1387	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP .
10815807	0	c-Myb	36,41	CBP	89,92	c-Myb	CBP	4602	1387	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|interaction interaction|nmod|END_ENTITY	HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300 .
11073948	0	c-Myb	22,27	CBP	54,57	c-Myb	CBP	4602	1387	Gene	Gene	START_ENTITY|nmod|CREB-binding_protein CREB-binding_protein|appos|END_ENTITY	Increased affinity of c-Myb for CREB-binding_protein -LRB- CBP -RRB- after CBP-induced acetylation .
15019774	0	c-Myb	83,88	CBP	40,43	c-Myb	CBP	4602	1387	Gene	Gene	domain|nmod|START_ENTITY bound|nmod|domain bound|nsubj|structure structure|nmod|domain domain|nmod|END_ENTITY	Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb .
27082784	0	c-Myb	102,107	CBP	56,59	c-Myb	CBP	17863(Tax:10090)	12914(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY CBP|amod|complex stability|nmod|CBP affects|dobj|stability affects|nsubj|mutation mutation|compound|END_ENTITY	Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP : c-Myb complex .
27082784	0	c-Myb	102,107	CBP	98,101	c-Myb	CBP	17863(Tax:10090)	12914(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	Experimental and molecular dynamics studies showed that CBP KIX mutation affects the stability of CBP : c-Myb complex .
19737967	0	c-Myb	33,38	CBP/p300	64,72	c-Myb	CBP/p300	4602	1387;2033	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Mutations in multiple domains of c-Myb disrupt interaction with CBP/p300 and abrogate myeloid transforming ability .
12196545	0	c-Myb	120,125	CREB	142,146	c-Myb	CREB	4602	1385	Gene	Gene	constitutive|appos|START_ENTITY constitutive|appos|END_ENTITY	Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding_protein by constitutive -LRB- c-Myb -RRB- and inducible -LRB- CREB -RRB- activators .
22880131	0	c-Myb	0,5	Erbin	51,56	c-Myb	Erbin	4602	55914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	c-Myb regulates cell cycle-dependent expression of Erbin : an implication for a novel function of Erbin .
22880131	0	c-Myb	0,5	Erbin	97,102	c-Myb	Erbin	4602	55914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|dep|implication implication|nmod|function function|nmod|END_ENTITY	c-Myb regulates cell cycle-dependent expression of Erbin : an implication for a novel function of Erbin .
19421138	0	c-Myb	49,54	Fbw7	0,4	c-Myb	Fbw7	17863(Tax:10090)	50754(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Fbw7 promotes ubiquitin-dependent degradation of c-Myb : involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb .
22910413	0	c-Myb	25,30	Fbxw5	0,5	c-Myb	Fbxw5	4602	54461	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	Fbxw5 suppresses nuclear c-Myb activity via DDB1-Cul4-Rbx1 ligase-mediated sumoylation .
19646965	0	c-Myb	21,26	HIPK1	0,5	c-Myb	HIPK1	4602	204851	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HIPK1 interacts with c-Myb and modulates its activity through phosphorylation .
22039304	0	c-Myb	0,5	IL-13	40,45	c-Myb	IL-13	4602	3596	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|compound|END_ENTITY	c-Myb and GATA-3 cooperatively regulate IL-13 expression via conserved GATA-3 response element and recruit mixed_lineage_leukemia -LRB- MLL -RRB- for histone modification of the IL-13 locus .
20093773	0	c-Myb	0,5	MLL	12,15	c-Myb	MLL	4602	4297	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis .
24675898	0	c-Myb	110,115	MicroRNA-424	0,12	c-Myb	MicroRNA-424	4602	494336	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|END_ENTITY	MicroRNA-424 is down-regulated in hepatocellular carcinoma and suppresses cell migration and invasion through c-Myb .
15194430	0	c-Myb	0,5	PML	22,25	c-Myb	PML	4602	5371	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	c-Myb associates with PML in nuclear bodies in hematopoietic cells .
18359295	0	c-Myb	20,25	Pin1	0,4	c-Myb	Pin1	4602	5300	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity .
20622260	0	c-Myb	35,40	Slug	14,18	c-Myb	Slug	4602	6591	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of Slug is regulated by c-Myb and is required for invasion and bone marrow homing of cancer cells of different origin .
9136080	0	c-Myb	140,145	Sp1	125,128	c-Myb	Sp1	4602	6667	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Structure and function analysis of the human myeloid cell nuclear differentiation antigen promoter : evidence for the role of Sp1 and not of c-Myb or PU .1 in myelomonocytic lineage-specific expression .
15082531	0	c-Myb	56,61	TAK1	74,78	c-Myb	TAK1	4602	6885	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1 , HIPK2 , and NLK .
9765496	0	c-Myb	96,101	Tax	51,54	c-Myb	Tax	4602	1491938(Tax:11908)	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	The human_T-cell_leukemia_virus_type_1 oncoprotein Tax inhibits the transcriptional activity of c-Myb through competition for the CREB_binding_protein .
18814950	0	c-Myb	25,30	Thrombopoietin	0,14	c-Myb	Thrombopoietin	4602	7066	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression .
22253833	0	c-Myb	77,82	Vav1	6,10	c-Myb	Vav1	4602	7409	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Human Vav1 expression in hematopoietic and cancer cell lines is regulated by c-Myb and by CpG methylation .
15687240	0	c-Myb	36,41	cyclin_D1	45,54	c-Myb	cyclin D1	4602	595	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive and negative regulation of c-Myb by cyclin_D1 , cyclin-dependent kinases , and p27_Kip1 .
16263717	0	c-Myb	0,5	glucocorticoid_receptor	141,164	c-Myb	glucocorticoid receptor	4602	2908	Gene	Gene	act|nsubj|START_ENTITY act|advcl|mediate mediate|dobj|regulation regulation|nmod|promoter promoter|compound|END_ENTITY	c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid_receptor 1A promoter .
22516378	0	c-Myb	0,5	glucocorticoid_receptor	25,48	c-Myb	glucocorticoid receptor	4602	2908	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	c-Myb interacts with the glucocorticoid_receptor and regulates its level in pre-B-acute_lymphoblastic_leukemia cells .
18667440	0	c-Myb	0,5	miR-150	35,42	c-Myb	miR-150	30519(Tax:7955)	100033674(Tax:7955)	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	c-Myb is an evolutionary conserved miR-150 target and miR-150 / c-Myb interaction is important for embryonic development .
24753318	0	c-Myb	127,132	mixed_lineage_leukemia_protein	50,80	c-Myb	mixed lineage leukemia protein	4602	4297	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The mechanism of binding of the KIX domain to the mixed_lineage_leukemia_protein and its allosteric role in the recognition of c-Myb .
20385574	0	c-Myb	57,62	p300	124,128	c-Myb	p300	4602	2033	Gene	Gene	recruitment|amod|START_ENTITY recruitment|amod|END_ENTITY	A SUMO-regulated activation_function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment .
24257756	0	c-Myb	44,49	p38	53,56	c-Myb	p38	4602	1432	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2 / 3 .
11500059	0	c-Myb	14,19	p53	49,52	c-Myb	p53	4602	7157	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of c-Myb activity by tumor suppressor p53 .
12244173	0	c-Myb	114,119	recombination-activating_gene-2	59,90	c-Myb	recombination-activating gene-2	4602	5897	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|promoter promoter|amod|END_ENTITY	Lymphoid_enhancer-binding_factor-1 binds and activates the recombination-activating_gene-2 promoter together with c-Myb and Pax-5 in immature B cells .
15071178	0	c-Myb	34,39	thrombopoietin	117,131	c-Myb	thrombopoietin	17863(Tax:10090)	21832(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY Mpl|dep|mutation screen|nmod|Mpl causes|nsubj|screen causes|dobj|production production|nmod|platelets platelets|nmod|absence absence|nmod|END_ENTITY	Suppressor screen in Mpl - / - mice : c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling .
24813121	0	c-Myc	80,85	ADAR1	55,60	c-Myc	ADAR1	4609	103	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Novel interaction of the Z-DNA binding domain of human ADAR1 with the oncogenic c-Myc promoter G-quadruplex .
21052002	0	c-Myc	49,54	BMI-1	42,47	c-Myc	BMI-1	4609	648	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|compound|END_ENTITY	Implication of USP22 in the regulation of BMI-1 , c-Myc , p16INK4a , p14ARF , and cyclin_D2 expression in primary colorectal_carcinomas .
21668996	0	c-Myc	0,5	BRCA1	16,21	c-Myc	BRCA1	4609	672	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nummod|END_ENTITY	c-Myc activates BRCA1 gene expression through distal promoter elements in breast_cancer cells .
9788437	0	c-Myc	12,17	BRCA1	0,5	c-Myc	BRCA1	4609	672	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells .
11337016	0	c-Myc	56,61	Bcl-2	82,87	c-Myc	Bcl-2	4609	596	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein down-regulate|dobj|expression down-regulate|nmod|END_ENTITY	Labdane type diterpenes down-regulate the expression of c-Myc protein , but not of Bcl-2 , in human leukemia T-cells undergoing apoptosis .
11704823	0	c-Myc	48,53	Bcl-2	0,5	c-Myc	Bcl-2	4609	596	Gene	Gene	suppressed|nmod|START_ENTITY target|acl|suppressed target|nsubj|END_ENTITY	Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1 .
17331788	0	c-Myc	0,5	Bcl-2	173,178	c-Myc	Bcl-2	24577(Tax:10116)	24224(Tax:10116)	Gene	Gene	overexpression|amod|START_ENTITY sensitizes|nsubj|overexpression sensitizes|dobj|activation activation|nmod|apoptosis apoptosis|acl|induced induced|nmod|suberoylanilide_hydroxamic_acid suberoylanilide_hydroxamic_acid|nmod|expression expression|dep|END_ENTITY	c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- through regulating Bcl-2 / Bcl-xL expression .
21640157	0	c-Myc	42,47	Bcl-2	0,5	c-Myc	Bcl-2	4609	596	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Bcl-2 is a better therapeutic target than c-Myc , but attacking both could be a more effective treatment strategy for B-cell_lymphoma with concurrent Bcl-2 and c-Myc overexpression .
7987827	0	c-Myc	65,70	Bcl-2	23,28	c-Myc	Bcl-2	4609	100774873	Gene	Gene	overexpression|amod|START_ENTITY induced|nmod|overexpression induced|nsubj|member member|nmod|family family|compound|END_ENTITY	Mcl-1 , a member of the Bcl-2 family , delays apoptosis induced by c-Myc overexpression in Chinese_hamster ovary cells .
12370803	0	c-Myc	20,25	Bcr-Abl	39,46	c-Myc	Bcr-Abl	4609	25	Gene	Gene	induction|amod|START_ENTITY involved|nmod|induction involved|nmod|END_ENTITY	Jak2 is involved in c-Myc induction by Bcr-Abl .
22543587	0	c-Myc	36,41	CHIP	21,25	c-Myc	CHIP	4609	358	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity .
24794748	0	c-Myc	86,91	D1_and_B1	104,113	c-Myc	D1 and B1	4609	25802;7716	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1_and_B1 mRNA and upregulation of p21 cell cycle inhibitor expression .
27009366	0	c-Myc	12,17	ELL	0,3	c-Myc	ELL	4609	8178	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	ELL targets c-Myc for proteasomal degradation and suppresses tumour growth .
25944903	0	c-Myc	15,20	FBXO32	0,6	c-Myc	FBXO32	4609	114907	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity .
25944903	0	c-Myc	15,20	FBXO32	0,6	c-Myc	FBXO32	4609	114907	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity .
8206526	0	c-Myc	51,56	HLA-B	31,36	c-Myc	HLA-B	4609	3106	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional suppression of HLA-B expression by c-Myc is mediated through the core promoter elements .
26279298	0	c-Myc	14,19	JMJD1A	58,64	c-Myc	JMJD1A	4609	55818	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate_cancer cell growth and survival .
9192621	0	c-Myc	0,5	LDH-A	25,30	c-Myc	LDH-A	4609	3939	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	c-Myc transactivation of LDH-A : implications for tumor metabolism and growth .
25528440	0	c-Myc	77,82	LTBP1	96,101	c-Myc	LTBP1	4609	4052	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	Marek * _ s_disease_virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-b signaling pathway .
26656491	0	c-Myc	18,23	Linc-RoR	0,8	c-Myc	Linc-RoR	4609	100885779	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Linc-RoR promotes c-Myc expression through hnRNP_I and AUF1 .
25546234	0	c-Myc	60,65	MicroRNA-33b	0,12	c-Myc	MicroRNA-33b	4609	693120	Gene	Gene	Suppresses|nmod|START_ENTITY Suppresses|nsubj|END_ENTITY	MicroRNA-33b Suppresses Migration and Invasion by Targeting c-Myc in Osteosarcoma Cells .
20697356	0	c-Myc	63,68	Miz-1	57,62	c-Myc	Miz-1	4609	7709	Gene	Gene	regulation|parataxis|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Wnt_inhibitory_factor-1 by Miz-1 / c-Myc .
20970423	0	c-Myc	16,21	NEMO	0,4	c-Myc	NEMO	4609	8517	Gene	Gene	stabilizes|xcomp|START_ENTITY stabilizes|nsubj|END_ENTITY	NEMO stabilizes c-Myc through direct interaction in the nucleus .
22333584	0	c-Myc	34,39	NFAT1	52,57	c-Myc	NFAT1	4609	4773	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements .
24677544	0	c-Myc	0,5	NKG2D	30,35	c-Myc	NKG2D	4609	22914	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	c-Myc regulates expression of NKG2D ligands ULBP1/2/3 in AML and modulates their susceptibility to NK-mediated lysis .
25193865	0	c-Myc	15,20	PIWIL2	0,6	c-Myc	PIWIL2	4609	55124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation .
19150964	0	c-Myc	25,30	Pten	0,4	c-Myc	Pten	4609	5728	Gene	Gene	converge|advcl|START_ENTITY converge|nsubj|END_ENTITY	Pten and p53 converge on c-Myc to control differentiation , self-renewal , and transformation of normal and neoplastic stem cells in glioblastoma .
23775087	0	c-Myc	43,48	S14	18,21	c-Myc	S14	4609	6208	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Ribosomal protein S14 negatively regulates c-Myc activity .
26407074	0	c-Myc	100,105	SALL4	0,5	c-Myc	SALL4	4609	57167	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nmod|Regulation	SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer .
25893300	0	c-Myc	15,20	SCP1	0,4	c-Myc	SCP1	4609	58190	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Ser62 .
16785237	0	c-Myc	117,122	Smad3	93,98	c-Myc	Smad3	4609	4088	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
26447186	0	c-Myc	83,88	Sox2	63,67	c-Myc	Sox2	4609	6657	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Galectin-3 modulates the EGFR signaling-mediated regulation of Sox2 expression via c-Myc in lung_cancer .
8755740	0	c-Myc	30,35	TATA_binding_protein	68,88	c-Myc	TATA binding protein	4609	6908	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Functional interaction of the c-Myc transactivation domain with the TATA_binding_protein : evidence for an induced fit model of transactivation domain folding .
18806825	0	c-Myc	71,76	TCEAL7	43,49	c-Myc	TCEAL7	4609	56849	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity END_ENTITY|nmod|regulation	A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity , cyclin_D1 levels and cellular transformation .
24152439	0	c-Myc	19,24	TDAG8	127,132	c-Myc	TDAG8	4609	8477	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Acidosis decreases c-Myc oncogene expression in human lymphoma cells : a role for the proton-sensing G protein-coupled receptor TDAG8 .
7957110	0	c-Myc	0,5	TNF-alpha	65,74	c-Myc	TNF-alpha	4609	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|action action|nmod|END_ENTITY	c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha .
20697356	0	c-Myc	63,68	Wnt_inhibitory_factor-1	30,53	c-Myc	Wnt inhibitory factor-1	4609	11197	Gene	Gene	regulation|parataxis|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Wnt_inhibitory_factor-1 by Miz-1 / c-Myc .
12080043	0	c-Myc	19,24	Y-box-binding_protein-1	37,60	c-Myc	Y-box-binding protein-1	4609	4904	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|END_ENTITY	p73 Interacts with c-Myc to regulate Y-box-binding_protein-1 expression .
23108410	0	c-Myc	59,64	b-catenin	40,49	c-Myc	b-catenin	4609	1499	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|activation activation|nmod|END_ENTITY	Hepatitis_C virus-induced activation of b-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events .
25663530	0	c-Myc	20,25	b-catenin	0,9	c-Myc	b-catenin	4609	1499	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	b-catenin regulates c-Myc and CDKN1A expression in breast_cancer cells .
15017589	0	c-Myc	76,81	beta-catenin	62,74	c-Myc	beta-catenin	4609	1499	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical evaluation of adenomatous_polyposis_coli , beta-catenin , c-Myc , cyclin_D1 , p53 , and retinoblastoma protein expression in syndromic and sporadic fundic_gland_polyps .
18852287	0	c-Myc	107,112	beta-catenin	25,37	c-Myc	beta-catenin	4609	1499	Gene	Gene	expression|amod|START_ENTITY controls|dobj|expression element|acl:relcl|controls identifies|dobj|element identifies|nsubj|screen screen|nmod|sites sites|amod|END_ENTITY	A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression .
18433872	0	c-Myc	53,58	beta-defensin_1	20,35	c-Myc	beta-defensin 1	4609	1672	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of human beta-defensin_1 is regulated via c-Myc and the biological clock .
21404708	0	c-Myc	66,71	c-fos	59,64	c-Myc	c-fos	24577(Tax:10116)	314322(Tax:10116)	Gene	Gene	polychlorinated_biphenyl|amod|START_ENTITY polychlorinated_biphenyl|nmod|END_ENTITY	-LSB- Effects of polychlorinated_biphenyl on the expressions of c-fos , c-Myc and beta-catenin in the rat testis -RSB- .
15017589	0	c-Myc	76,81	cyclin_D1	83,92	c-Myc	cyclin D1	4609	595	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical evaluation of adenomatous_polyposis_coli , beta-catenin , c-Myc , cyclin_D1 , p53 , and retinoblastoma protein expression in syndromic and sporadic fundic_gland_polyps .
26125720	0	c-Myc	60,65	endostatin	28,38	c-Myc	endostatin	4609	80781	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric_cancer cells .
12761891	0	c-Myc	7,12	hMad4	0,5	c-Myc	hMad4	4609	4089	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	hMad4 , c-Myc endogenous inhibitor , induces a replicative senescence-like state when overexpressed in human fibroblasts .
10637317	0	c-Myc	20,25	hTERT	104,109	c-Myc	hTERT	4609	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene -LRB- hTERT -RRB- .
12082531	0	c-Myc	68,73	hTERT	18,23	c-Myc	hTERT	4609	7015	Gene	Gene	clones|amod|START_ENTITY restores|nmod|clones restores|nsubj|Reconstitution Reconstitution|nmod|END_ENTITY	Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones .
14563552	0	c-Myc	46,51	hTERT	36,41	c-Myc	hTERT	4609	7015	Gene	Gene	fibroblasts|amod|START_ENTITY telomerase|nmod|fibroblasts telomerase|appos|END_ENTITY	Induction of endogenous telomerase -LRB- hTERT -RRB- by c-Myc in WI-38 fibroblasts transformed with specific genetic elements .
16785237	0	c-Myc	117,122	hTERT	83,88	c-Myc	hTERT	4609	7015	Gene	Gene	interactions|nmod|START_ENTITY suppresses|nmod|interactions suppresses|dep|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
18586674	0	c-Myc	94,99	hTERT	15,20	c-Myc	hTERT	4609	7015	Gene	Gene	interacting|advcl|START_ENTITY maintains|advcl|interacting maintains|dobj|expression expression|amod|END_ENTITY	Ets2 maintains hTERT gene expression and breast_cancer cell proliferation by interacting with c-Myc .
20454512	0	c-Myc	21,26	hTERT	86,91	c-Myc	hTERT	4609	7015	Gene	Gene	activity|amod|START_ENTITY inhibition|nmod|activity regulates|nsubj|inhibition regulates|dobj|expression expression|amod|END_ENTITY	TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression .
22207128	0	c-Myc	105,110	hTERT	40,45	c-Myc	hTERT	4609	7015	Gene	Gene	activation|nmod|START_ENTITY cells|nmod|activation transcription|nmod|cells transcription|amod|END_ENTITY	E2F1 : a potential negative regulator of hTERT transcription in normal cells upon activation of oncogenic c-Myc .
23860446	0	c-Myc	93,98	hTERT	26,31	c-Myc	hTERT	379052(Tax:8355)	7015	Gene	Gene	dynamics|nmod|START_ENTITY dynamics|nmod|promoter promoter|amod|END_ENTITY	Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus_leavis oocytes .
24969314	0	c-Myc	46,51	hTERT	62,67	c-Myc	hTERT	4609	7015	Gene	Gene	regulator|nmod|START_ENTITY acts|nmod|regulator acts|dep|transcription transcription|compound|END_ENTITY	E2F1 acts as a negative feedback regulator of c-Myc - induced hTERT transcription during tumorigenesis .
25170084	0	c-Myc	14,19	hTERT	41,46	c-Myc	hTERT	4609	7015	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|regulation regulation|nmod|gene gene|amod|END_ENTITY	Dual roles of c-Myc in the regulation of hTERT gene .
26689987	0	c-Myc	105,110	hTERT	40,45	c-Myc	hTERT	4609	7015	Gene	Gene	cooperating|advcl|START_ENTITY promotes|advcl|cooperating promotes|nsubj|telomerase_reverse_transcriptase telomerase_reverse_transcriptase|appos|END_ENTITY	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- promotes gastric_cancer invasion through cooperating with c-Myc to upregulate heparanase expression .
11818252	0	c-Myc	63,68	interleukin-6	130,143	c-Myc	interleukin-6	24577(Tax:10116)	24498(Tax:10116)	Gene	Gene	rats|amod|START_ENTITY rats|dep|role role|nmod|END_ENTITY	Ductular_hyperplasia is characterized by an over expression of c-Myc in bile duct ligation + furan injured rats : possible role of interleukin-6 .
19202062	0	c-Myc	14,19	miR-145	62,69	c-Myc	miR-145	4609	406937	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	p53 represses c-Myc through induction of the tumor suppressor miR-145 .
21901171	0	c-Myc	17,22	miR-26a	80,87	c-Myc	miR-26a	4609	407015	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Regulation Regulation|nmod|END_ENTITY	Critical Role of c-Myc in Acute_Myeloid_Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2 .
19179065	0	c-Myc	14,19	ncRNA	23,28	c-Myc	ncRNA	4609	104968399	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation by c-Myc of ncRNA expression .
12435808	0	c-Myc	0,5	ornithine_decarboxylase	43,66	c-Myc	ornithine decarboxylase	4609	4953	Gene	Gene	exerts|nsubj|START_ENTITY exerts|nmod|END_ENTITY	c-Myc exerts a protective function through ornithine_decarboxylase against cellular insults .
12565711	0	c-Myc	132,137	ornithine_decarboxylase	34,57	c-Myc	ornithine decarboxylase	4609	4953	Gene	Gene	interacting|advcl|START_ENTITY regulation|acl|interacting regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the ornithine_decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc .
8262968	0	c-Myc	62,67	ornithine_decarboxylase	20,43	c-Myc	ornithine decarboxylase	4609	4953	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of human ornithine_decarboxylase expression by the c-Myc .
8297793	0	c-Myc	0,5	ornithine_decarboxylase	45,68	c-Myc	ornithine decarboxylase	4609	4953	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	c-Myc induces the expression and activity of ornithine_decarboxylase .
8356088	0	c-Myc	64,69	ornithine_decarboxylase	4,27	c-Myc	ornithine decarboxylase	4609	4953	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	The ornithine_decarboxylase gene is a transcriptional target of c-Myc .
8076603	0	c-Myc	15,20	p107	50,54	c-Myc	p107	4609	5933	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation .
25915540	0	c-Myc	105,110	p110a	30,35	c-Myc	p110a	4609	5290	Gene	Gene	Expression|acl|START_ENTITY Expression|amod|END_ENTITY	The Phosphoinositide 3-Kinase p110a Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma .
25915540	0	c-Myc	105,110	p110a	30,35	c-Myc	p110a	4609	5290	Gene	Gene	Expression|acl|START_ENTITY Expression|amod|END_ENTITY	The Phosphoinositide 3-Kinase p110a Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma .
23516888	0	c-Myc	32,37	p14	39,42	c-Myc	p14	4609	11102	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	-LSB- Expression of P53 , NPM1 , Kras , c-Myc , p14 -LRB- ARF -RRB- genes in blood cells of cancer patients before and after radiation therapy -RSB- .
21052002	0	c-Myc	49,54	p16INK4a	56,64	c-Myc	p16INK4a	4609	1029	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|dep|END_ENTITY	Implication of USP22 in the regulation of BMI-1 , c-Myc , p16INK4a , p14ARF , and cyclin_D2 expression in primary colorectal_carcinomas .
18570961	0	c-Myc	53,58	p300	34,38	c-Myc	p300	4609	2033	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Simian_virus_40 large T overcomes p300 repression of c-Myc .
10200458	0	c-Myc	34,39	p53	0,3	c-Myc	p53	24577(Tax:10116)	301300(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY induced|nmod|activation apoptosis|dep|induced apoptosis|nsubj|mediates mediates|compound|END_ENTITY	p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts .
10822369	0	c-Myc	0,5	p53	32,35	c-Myc	p53	4609	7157	Gene	Gene	antagonizes|amod|START_ENTITY antagonizes|dep|effect effect|nmod|END_ENTITY	c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells .
18372915	0	c-Myc	0,5	p53	46,49	c-Myc	p53	4609	22060(Tax:10090)	Gene	Gene	cooperate|nsubj|START_ENTITY cooperate|nmod|loss loss|nmod|END_ENTITY	c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal_tumor family in mice .
19202062	0	c-Myc	14,19	p53	0,3	c-Myc	p53	4609	7157	Gene	Gene	represses|xcomp|START_ENTITY represses|nsubj|END_ENTITY	p53 represses c-Myc through induction of the tumor suppressor miR-145 .
21828057	0	c-Myc	55,60	p53	23,26	c-Myc	p53	4609	7157	Gene	Gene	transduction|nmod|START_ENTITY followed|nmod|transduction END_ENTITY|acl|followed	Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells .
25692307	0	c-Myc	24,29	p53	47,50	c-Myc	p53	4609	7157	Gene	Gene	independently|amod|START_ENTITY independently|nmod|END_ENTITY	Inauhzin -LRB- c -RRB- inactivates c-Myc independently of p53 .
25710583	0	c-Myc	63,68	p53	51,54	c-Myc	p53	4609	7157	Gene	Gene	c-Jun|nummod|START_ENTITY c-Jun|compound|END_ENTITY	The Differential Immunohistochemical Expression of p53 , c-Jun , c-Myc , and p21 Between HCV-related Hepatocellular_Carcinoma With and Without Cirrhosis .
8494784	0	c-Myc	0,5	p53	26,29	c-Myc	p53	4609	7157	Gene	Gene	trans-activates|amod|START_ENTITY trans-activates|dep|promoter promoter|compound|END_ENTITY	c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif .
18583030	0	c-Myc	19,24	thrombospondin-1	69,85	c-Myc	thrombospondin-1	4609	7057	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Down regulation of c-Myc and induction of an angiogenesis inhibitor , thrombospondin-1 , by 5-FU in human colon_cancer KM12C cells .
8065303	0	c-Myc	8,13	tumor_necrosis_factor_alpha	61,88	c-Myc	tumor necrosis factor alpha	4609	7124	Gene	Gene	plays|nsubj|START_ENTITY plays|dobj|role role|nmod|cytotoxicity cytotoxicity|nmod|END_ENTITY	Nuclear c-Myc plays an important role in the cytotoxicity of tumor_necrosis_factor_alpha in tumor cells .
26058013	0	c-RAF	20,25	RAF1	14,18	c-RAF	RAF1	5894	5894	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of RAF1 -LRB- c-RAF -RRB- by the Marine Alkaloid Lasonolide_A Induces Rapid Premature Chromosome Condensation .
22186412	0	c-Raf	23,28	ERK	0,3	c-Raf	ERK	110157(Tax:10090)	26413(Tax:10090)	Gene	Gene	signaling|dep|START_ENTITY signaling|compound|END_ENTITY	ERK signaling , but not c-Raf , is required for gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced regulation of Nur77 in pituitary gonadotropes .
19384851	0	c-Raf	117,122	ERK1/2	88,94	c-Raf	ERK1/2	24703(Tax:10116)	50689;116590	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Parathyroid_hormone inhibits phosphorylation of mitogen-activated protein kinase -LRB- MAPK -RRB- ERK1/2 through inhibition of c-Raf and activation of MKP-1 in osteoblastic cells .
26683769	0	c-Raf	87,92	Kras	21,25	c-Raf	Kras	110157(Tax:10090)	16653(Tax:10090)	Gene	Gene	t-CUPM|amod|START_ENTITY initiated|nmod|t-CUPM Inhibition|acl|initiated Inhibition|nmod|END_ENTITY	Inhibition of mutant Kras -LRB- G12D -RRB- - initiated murine pancreatic_carcinoma growth by a dual c-Raf and soluble_epoxide_hydrolase inhibitor t-CUPM .
12730674	0	c-Raf-1	13,20	MEK	21,24	c-Raf-1	MEK	7187	5609	Gene	Gene	cascade|amod|START_ENTITY cascade|compound|END_ENTITY	Integrity of c-Raf-1 / MEK signal transduction cascade is essential for hepatitis_B virus gene expression .
26522720	0	c-Rel	18,23	Bach2	34,39	c-Rel	Bach2	19696(Tax:10090)	12014(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The NF-kB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell_lymphoma .
12426000	0	c-Rel	39,44	Bcl-xL	78,84	c-Rel	Bcl-xL	5966	598	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL , Mcl-1 , and Bcl-2 .
14522018	0	c-Rel	21,26	C-reactive_protein	36,54	c-Rel	C-reactive protein	5966	1401	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|amod|END_ENTITY	Transcription factor c-Rel enhances C-reactive_protein expression by facilitating the binding of C/EBPbeta to the promoter .
19995950	0	c-Rel	0,5	CD4	55,58	c-Rel	CD4	19696(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|cells cells|compound|END_ENTITY	c-Rel is required for the development of thymic Foxp3 + CD4 regulatory T cells .
20049877	0	c-Rel	0,5	CD4	58,61	c-Rel	CD4	5966	920	Gene	Gene	crucial|nsubj|START_ENTITY crucial|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	c-Rel is crucial for the induction of Foxp3 -LRB- + -RRB- regulatory CD4 -LRB- + -RRB- T cells but not T -LRB- H -RRB- 17 cells .
11922943	0	c-Rel	0,5	CD40	47,51	c-Rel	CD40	5966	958	Gene	Gene	activator|nsubj|START_ENTITY activator|nmod|element element|dep|responsive responsive|dep|END_ENTITY	c-Rel is a selective activator of a novel IL-4 / CD40 responsive element in the human Ig gamma4 germline promoter .
17567982	0	c-Rel	28,33	CD40	8,12	c-Rel	CD40	5966	958	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell_lymphoma .
19621336	0	c-Rel	0,5	EPHB2	40,45	c-Rel	EPHB2	5966	2048	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	c-Rel is a transcriptional repressor of EPHB2 in colorectal_cancer .
25266721	0	c-Rel	0,5	Ezh2	16,20	c-Rel	Ezh2	5966	2146	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells .
19995950	0	c-Rel	0,5	Foxp3	48,53	c-Rel	Foxp3	19696(Tax:10090)	20371(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|cells cells|compound|END_ENTITY	c-Rel is required for the development of thymic Foxp3 + CD4 regulatory T cells .
20049877	0	c-Rel	0,5	Foxp3	38,43	c-Rel	Foxp3	5966	50943	Gene	Gene	crucial|nsubj|START_ENTITY crucial|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	c-Rel is crucial for the induction of Foxp3 -LRB- + -RRB- regulatory CD4 -LRB- + -RRB- T cells but not T -LRB- H -RRB- 17 cells .
20064450	0	c-Rel	60,65	Foxp3	15,20	c-Rel	Foxp3	19696(Tax:10090)	20371(Tax:10090)	Gene	Gene	enhanceosome|amod|START_ENTITY driven|nmod|enhanceosome driven|nsubjpass|Development Development|nmod|cells cells|amod|END_ENTITY	Development of Foxp3 -LRB- + -RRB- regulatory t cells is driven by the c-Rel enhanceosome .
21490927	0	c-Rel	21,26	Foxp3	0,5	c-Rel	Foxp3	5966	50943	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Foxp3 interacts with c-Rel to mediate NF-kB repression .
22066012	0	c-Rel	0,5	Foxp3	68,73	c-Rel	Foxp3	19696(Tax:10090)	20371(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|development development|nmod|cells cells|amod|END_ENTITY	c-Rel controls multiple discrete steps in the thymic development of Foxp3 + CD4 regulatory T cells .
20639489	0	c-Rel	63,68	IL-21	18,23	c-Rel	IL-21	19696(Tax:10090)	60505(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the IL-21 gene by the NF-kB transcription factor c-Rel .
17182554	0	c-Rel	19,24	IL-23_p19	40,49	c-Rel	IL-23 p19	19696(Tax:10090)	83430(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|expression expression|compound|END_ENTITY	Essential roles of c-Rel in TLR-induced IL-23_p19 gene expression in dendritic cells .
10713713	0	c-Rel	87,92	I_kappa_B_alpha	27,42	c-Rel	I kappa B alpha	5966	4792	Gene	Gene	regulation|nmod|START_ENTITY necessary|nmod|regulation determinants|amod|necessary determinants|nmod|END_ENTITY	N-terminal determinants of I_kappa_B_alpha necessary for the cytoplasmic regulation of c-Rel .
7636983	0	c-Rel	54,59	I_kappa_B_alpha	6,21	c-Rel	I kappa B alpha	5966	4792	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Avian I_kappa_B_alpha is transcriptionally induced by c-Rel and v-Rel with different kinetics .
10586083	0	c-Rel	38,43	NF-kappa_B	0,10	c-Rel	NF-kappa B	19696(Tax:10090)	18033(Tax:10090)	Gene	Gene	hyperresponsiveness|amod|START_ENTITY Rel|dep|hyperresponsiveness END_ENTITY|dep|Rel	NF-kappa_B / Rel transcription factors : c-Rel promotes airway hyperresponsiveness and allergic pulmonary_inflammation .
10823840	0	c-Rel	126,131	NF-kappa_B	42,52	c-Rel	NF-kappa B	5966	4790	Gene	Gene	domain|nmod|START_ENTITY Ser-471|nmod|domain phosphorylation|nmod|Ser-471 requires|dobj|phosphorylation requires|nsubj|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha activation of NF-kappa_B requires the phosphorylation of Ser-471 in the transactivation domain of c-Rel .
8505309	0	c-Rel	69,74	NF-kappa_B	87,97	c-Rel	NF-kappa B	5966	4790	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa_B proteins in human monocytic THP-1 cells .
8972019	0	c-Rel	74,79	NF-kappa_B	63,73	c-Rel	NF-kappa B	5966	4790	Gene	Gene	translocation|amod|START_ENTITY END_ENTITY|dep|translocation	Acetylsalicylic_acid and sodium_salicylate inhibit LPS-induced NF-kappa_B / c-Rel nuclear translocation , and synthesis of tissue factor -LRB- TF -RRB- and tumor necrosis factor alfa -LRB- TNF-alpha -RRB- in human monocytes .
18927440	0	c-Rel	35,40	PI3K	26,30	c-Rel	PI3K	19696(Tax:10090)	18708(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Critical role of class IA PI3K for c-Rel expression in B lymphocytes .
10050877	0	c-Rel	11,16	STAT5	20,25	c-Rel	STAT5	5966	6776	Gene	Gene	START_ENTITY|nmod|target target|compound|END_ENTITY	Binding of c-Rel to STAT5 target sequences in HTLV-I-transformed T cells .
17011549	0	c-Rel	99,104	androgen_receptor	132,149	c-Rel	androgen receptor	5966	367	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Unraveling androgen_receptor interactomes by an array-based method : discovery of proto-oncoprotein c-Rel as a negative regulator of androgen_receptor .
25305492	0	c-Rel	38,43	p100	0,4	c-Rel	p100	5966	4791	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	p100 , a precursor of NF-kB2 , inhibits c-Rel and reduces the expression of IL-23 in dendritic cells .
9837938	0	c-Rel	37,42	phosphatase_X	8,21	c-Rel	phosphatase X	5966	5531	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protein phosphatase_X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity .
9371722	0	c-Ski	127,132	myogenin	20,28	c-Ski	myogenin	20481(Tax:10090)	17928(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY C-terminus|nmod|protein c-ski|dep|C-terminus activity|nmod|c-ski activity|compound|END_ENTITY	Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation : the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubes .
15890643	0	c-Src	209,214	Akt	247,250	c-Src	Akt	83805(Tax:10116)	24185(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
19262695	0	c-Src	0,5	Akt	16,19	c-Src	Akt	6714	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and - dependent mechanisms .
19704002	0	c-Src	0,5	ErbB2	22,27	c-Src	ErbB2	6714	2064	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential .
16407846	0	c-Src	31,36	HGF	50,53	c-Src	HGF	6714	3082	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	A novel activating function of c-Src and Stat3 on HGF transcription in mammary_carcinoma cells .
12719447	0	c-Src	42,47	JNK	72,75	c-Src	JNK	6714	5599	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Selective involvement of p130Cas/Crk/Pyk2 / c-Src in endothelin-1-induced JNK activation .
22090359	0	c-Src	77,82	Jak2	43,47	c-Src	Jak2	6714	3717	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous_carcinoma .
10455194	0	c-Src	136,141	KDR	118,121	c-Src	KDR	6714	3791	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
19665017	0	c-Src	36,41	MPP2	16,20	c-Src	MPP2	6714	50997(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The PDZ protein MPP2 interacts with c-Src in epithelial cells .
20471961	0	c-Src	56,61	MT1-MMP	0,7	c-Src	MT1-MMP	6714	4323	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix .
15890643	0	c-Src	209,214	MyD88	108,113	c-Src	MyD88	83805(Tax:10116)	301059(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY expression|dep|factor expression|nmod|cells cells|nmod|receptor-associated receptor-associated|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
22479394	0	c-Src	20,25	Notch-1	66,73	c-Src	Notch-1	6714	4851	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic_cancer cells .
9162084	0	c-Src	69,74	Platelet_endothelial_cell_adhesion_molecule-1	0,45	c-Src	Platelet endothelial cell adhesion molecule-1	6714	5175	Gene	Gene	binds|amod|START_ENTITY domain|amod|binds phosphorylatable|nmod|domain phosphorylatable|nsubj|END_ENTITY	Platelet_endothelial_cell_adhesion_molecule-1 is phosphorylatable by c-Src , binds Src-Src homology 2 domain , and exhibits immunoreceptor tyrosine-based activation motif-like properties .
15143162	0	c-Src	103,108	RasGRP3	128,135	c-Src	RasGRP3	6714	25780	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rap2B-dependent stimulation of phospholipase_C-epsilon by epidermal_growth_factor_receptor mediated by c-Src phosphorylation of RasGRP3 .
18353785	0	c-Src	122,127	Transforming_growth_factor_beta1	0,32	c-Src	Transforming growth factor beta1	6714	7040	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor_beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin - , c-Src - , and p38 MAPK-dependent pathway .
26058065	0	c-Src	92,97	Tyrosine_Kinase	64,79	c-Src	Tyrosine Kinase	6714	7294	Gene	Gene	Activity|nmod|START_ENTITY Activity|amod|END_ENTITY	Ca2 + / Calmodulin and Apo-Calmodulin Both Bind to and Enhance the Tyrosine_Kinase Activity of c-Src .
10455194	0	c-Src	136,141	Vascular_endothelial_growth_factor	0,34	c-Src	Vascular endothelial growth factor	6714	7422	Gene	Gene	activation|nmod|START_ENTITY signals|nmod|activation signals|nsubj|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
16227616	0	c-Src	131,136	alpha4	82,88	c-Src	alpha4	6714	18518(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Integrin alpha4beta1 promotes focal_adhesion_kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src .
12663375	0	c-Src	0,5	angiotensin_II	93,107	c-Src	angiotensin II	6714	183	Gene	Gene	induces|dep|START_ENTITY induces|nmod|END_ENTITY	c-Src induces phosphorylation and translocation of p47phox : role in superoxide generation by angiotensin_II in human vascular smooth muscle cells .
15890643	0	c-Src	209,214	c-Jun_N-terminal_kinase	252,275	c-Src	c-Jun N-terminal kinase	83805(Tax:10116)	116554(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
15749833	0	c-Src	19,24	c-Src	64,69	c-Src	c-Src	6714	6714	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Functional role of c-Src in IL-1-induced NF-kappa_B activation : c-Src is a component of the IKK complex .
15749833	0	c-Src	64,69	c-Src	19,24	c-Src	c-Src	6714	6714	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Functional role of c-Src in IL-1-induced NF-kappa_B activation : c-Src is a component of the IKK complex .
11483589	0	c-Src	104,109	epidermal_growth_factor_receptor	4,36	c-Src	epidermal growth factor receptor	6714	1956	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	The epidermal_growth_factor_receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin .
12750372	0	c-Src	0,5	epidermal_growth_factor_receptor	26,58	c-Src	epidermal growth factor receptor	6714	1956	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	c-Src is activated by the epidermal_growth_factor_receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing_hormone in COS7 cells .
14760089	0	c-Src	90,95	epidermal_growth_factor_receptor	4,36	c-Src	epidermal growth factor receptor	6714	1956	Gene	Gene	pathways|amod|START_ENTITY suppresses|dobj|pathways suppresses|nsubj|ZD1839 ZD1839|amod|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells .
15143162	0	c-Src	103,108	epidermal_growth_factor_receptor	58,90	c-Src	epidermal growth factor receptor	6714	1956	Gene	Gene	phosphorylation|amod|START_ENTITY mediated|nmod|phosphorylation mediated|nsubj|stimulation stimulation|nmod|phospholipase_C-epsilon phospholipase_C-epsilon|nmod|END_ENTITY	Rap2B-dependent stimulation of phospholipase_C-epsilon by epidermal_growth_factor_receptor mediated by c-Src phosphorylation of RasGRP3 .
7488034	0	c-Src	0,5	epidermal_growth_factor_receptor	21,53	c-Src	epidermal growth factor receptor	6714	1956	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	c-Src phosphorylates epidermal_growth_factor_receptor on tyrosine 845 .
10455194	0	c-Src	136,141	flk-1	112,117	c-Src	flk-1	6714	3791	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
17178840	0	c-Src	58,63	hnRNP_K	85,92	c-Src	hnRNP K	6714	3190	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Deciphering the cross talk between hnRNP_K and c-Src : the c-Src activation domain in hnRNP_K is distinct from a second interaction site .
15890643	0	c-Src	209,214	phosphatidylinositol_3-kinase	216,245	c-Src	phosphatidylinositol 3-kinase	83805(Tax:10116)	298947(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
17991742	0	c-Src	0,5	phosphatidylinositol_3-kinase	85,114	c-Src	phosphatidylinositol 3-kinase	6714	5293	Gene	Gene	required|dep|START_ENTITY required|nmod|tropomyosin_receptor_kinase_C tropomyosin_receptor_kinase_C|dep|induced induced|dobj|activation activation|nmod|END_ENTITY	c-Src is required for tropomyosin_receptor_kinase_C -LRB- TrkC -RRB- - induced activation of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- - AKT pathway .
25501895	0	c-Src	0,5	plakophilin_3	43,56	c-Src	plakophilin 3	6714	11187	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	c-Src mediated tyrosine phosphorylation of plakophilin_3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress .
18243211	0	c-Src	82,87	platelet_endothelial_cell_adhesion_molecule-1	32,77	c-Src	platelet endothelial cell adhesion molecule-1	6714	5175	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Coupling_factor_6 downregulates platelet_endothelial_cell_adhesion_molecule-1 via c-Src activation and acts as a proatherogenic molecule .
17991742	0	c-Src	0,5	tropomyosin_receptor_kinase_C	22,51	c-Src	tropomyosin receptor kinase C	6714	4916	Gene	Gene	required|dep|START_ENTITY required|nmod|END_ENTITY	c-Src is required for tropomyosin_receptor_kinase_C -LRB- TrkC -RRB- - induced activation of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- - AKT pathway .
10640727	0	c-Src	0,5	vascular_endothelial_growth_factor	80,114	c-Src	vascular endothelial growth factor	6714	7422	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|stimulation stimulation|compound|END_ENTITY	c-Src mediates mitogenic signals and associates with cytoskeletal proteins upon vascular_endothelial_growth_factor stimulation in Kaposi 's _ sarcoma cells .
18180305	0	c-Src	60,65	vascular_endothelial_growth_factor	105,139	c-Src	vascular endothelial growth factor	6714	7422	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	A novel role of vascular_endothelial_cadherin in modulating c-Src activation and downstream signaling of vascular_endothelial_growth_factor .
7540725	0	c-Src	81,86	vascular_endothelial_growth_factor	27,61	c-Src	vascular endothelial growth factor	6714	7422	Gene	Gene	activation|amod|START_ENTITY induction|nmod|activation induction|nmod|expression expression|compound|END_ENTITY	Hypoxic induction of human vascular_endothelial_growth_factor expression through c-Src activation .
16020549	0	c-Src_and_adhesion_and_degranulation_promoting_adaptor_protein	39,101	ADAP	103,107	c-Src and adhesion and degranulation promoting adaptor protein	ADAP	23880(Tax:10090)	23880(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Physical and functional association of c-Src_and_adhesion_and_degranulation_promoting_adaptor_protein -LRB- ADAP -RRB- in osteoclastogenesis in vitro .
11084024	0	c-Src_kinase	22,34	CD44	0,4	c-Src kinase	CD44	1445	960	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	CD44 interaction with c-Src_kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian_tumor cell migration .
16858407	0	c-Src_tyrosine_kinase	37,58	Toll-like_receptor_3	0,20	c-Src tyrosine kinase	Toll-like receptor 3	1445	7098	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Toll-like_receptor_3 associates with c-Src_tyrosine_kinase on endosomes to initiate antiviral signaling .
15368327	0	c-abl	29,34	bcr-abl	14,21	c-abl	bcr-abl	25	25	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibition of bcr-abl and/or c-abl gene expression by small interfering , double-stranded RNAs : cross-talk with cell proliferation factors and other oncogenes .
10871855	0	c-abl	0,5	p53	40,43	c-abl	p53	11350(Tax:10090)	22060(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|association association|nmod|END_ENTITY	c-abl is involved in the association of p53 and trk_A .
15378021	0	c-abl	8,13	p53	58,61	c-abl	p53	11350(Tax:10090)	22060(Tax:10090)	Gene	Gene	growth|amod|START_ENTITY growth|nmod|END_ENTITY	Loss of c-abl facilitates anchorage-independent growth of p53 - and RB - _ deficient primary mouse embryonic fibroblasts .
2672004	0	c-abl	87,92	tumor_necrosis_factor_alpha	12,39	c-abl	tumor necrosis factor alpha	25	7124	Gene	Gene	mRNA|amod|START_ENTITY END_ENTITY|nmod|mRNA	Recombinant tumor_necrosis_factor_alpha and interleukin_1_alpha increase expression of c-abl protooncogene mRNA in cultured human marrow stromal cells .
8576149	0	c-cbl	32,37	CD38	94,98	c-cbl	CD38	867	952	Gene	Gene	product|amod|START_ENTITY phosphorylation|nmod|product mediated|nsubj|phosphorylation mediated|nmod|END_ENTITY	Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells .
8458346	0	c-erbB	62,68	TGF_alpha	42,51	c-erbB	TGF alpha	396494(Tax:9031)	414743(Tax:9031)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The estrogen receptor cooperates with the TGF_alpha receptor -LRB- c-erbB -RRB- in regulation of chicken erythroid progenitor self-renewal .
10945494	0	c-erbB-2	50,58	C-Ki-ras	40,48	c-erbB-2	C-Ki-ras	2064	3845	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Multiple molecular marker testing -LRB- p53 , C-Ki-ras , c-erbB-2 -RRB- improves estimation of prognosis in potentially curative resected non-small_cell_lung_cancer .
12354693	0	c-erbB-2	123,131	EGFR	145,149	c-erbB-2	EGFR	2064	1956	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Induction of cancer cell migration by epidermal_growth_factor is initiated by specific phosphorylation of tyrosine 1248 of c-erbB-2 receptor via EGFR .
9673387	0	c-erbB-2	175,183	EGFR	169,173	c-erbB-2	EGFR	2064	1956	Gene	Gene	oncoprotein|amod|START_ENTITY oncoprotein|amod|END_ENTITY	Matrix metalloproteinase expression in human breast_cancer : an immunohistochemical study including correlation with cathepsin_D , type IV collagen , laminin , fibronectin , EGFR , c-erbB-2 oncoprotein , p53 , steroid receptors status and proliferative indices .
1356959	0	c-erbB-2	19,27	Estrogen_receptor	0,17	c-erbB-2	Estrogen receptor	2064	2099	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Estrogen_receptor , c-erbB-2 and nm23/NDP kinase expression in the intraductal and invasive components of human breast_cancers .
10560479	0	c-erbB-2	31,39	HER-2	41,46	c-erbB-2	HER-2	2064	2064	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Semiquantitative assessment of c-erbB-2 -LRB- HER-2 -RRB- status in cytology specimens and tissue sections from breast_carcinoma .
1357006	0	c-erbB-2	6,14	HER2	0,4	c-erbB-2	HER2	2064	2064	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	HER2 -LRB- c-erbB-2 -RRB- oncoprotein expression in colorectal_adenocarcinoma : an immunohistological study using three different antibodies .
14675323	0	c-erbB-2	27,35	HER2	36,40	c-erbB-2	HER2	2064	2064	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of c-erbB-2 / HER2 expression in advanced uterine cervical_carcinoma with para-aortic lymph node metastasis treated with radiation_therapy .
12013529	0	c-erbB-2	12,20	HER2/neu	21,29	c-erbB-2	HER2/neu	2064	2064	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of c-erbB-2 / HER2/neu in breast_cancer progression and metastasis .
17641798	0	c-erbB-2	17,25	HER2/neu	27,35	c-erbB-2	HER2/neu	2064	2064	Gene	Gene	status|amod|START_ENTITY status|compound|END_ENTITY	Angiogenesis and c-erbB-2 -LRB- HER2/neu -RRB- overexpression status in primary breast_cancer patients : an analysis of 158 needle core biopsies .
19050794	0	c-erbB-2	40,48	HER2/neu	50,58	c-erbB-2	HER2/neu	2064	2064	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Angiogenesis and co-expressed of ER and c-erbB-2 -LRB- HER2/neu -RRB- protein in primary breast_cancer patients : an analysis of 158 needle core biopsies .
7697605	0	c-erbB-2	13,21	INT-2	57,62	c-erbB-2	INT-2	2064	2248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Detection of c-erbB-2 / neu and fibroblast_growth_factor-3 / INT-2 but not epidermal_growth_factor_receptor gene amplification in endometrial_cancer by differential polymerase chain reaction .
15493177	0	c-erbB-2	5,13	P53	0,3	c-erbB-2	P53	2064	7157	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	P53 , c-erbB-2 expression and steroid hormone receptors in breast_carcinoma : correlations with histopathological parameters .
12760717	0	c-erbB-2	67,75	PCNA	56,60	c-erbB-2	PCNA	2064	5111	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Helicobacter_pylori_infection affects the expression of PCNA , p53 , c-erbB-2 and Bcl-2 in the human gastric mucosa .
1348890	0	c-erbB-2	57,65	TGF-alpha	92,101	c-erbB-2	TGF-alpha	2064	7039	Gene	Gene	EGF-R|dep|START_ENTITY products|dep|EGF-R products|appos|EGF EGF|dep|END_ENTITY	Immunohistochemical studies on oncogene products -LRB- EGF-R , c-erbB-2 -RRB- and growth factors -LRB- EGF , TGF-alpha -RRB- in human breast_cancer : their relationship to oestrogen receptor status , histological grade , mitotic index and nodal status .
16033092	0	c-erbB-2	11,19	TGF-alpha	0,9	c-erbB-2	TGF-alpha	2064	7039	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	TGF-alpha , c-erbB-2 expression and neoangiogenesis in vulvar_squamous_cell_carcinoma .
16244586	0	c-erbB-2	36,44	Vascular_endothelial_growth_factor	0,34	c-erbB-2	Vascular endothelial growth factor	2064	7422	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Vascular_endothelial_growth_factor , c-erbB-2 and c-erbB-3 expression in colorectal_adenoma and adenocarcinoma .
10604737	0	c-erbB-2	126,134	c-myc	17,22	c-erbB-2	c-myc	2064	4609	Gene	Gene	characteristics|amod|START_ENTITY value|nmod|characteristics evaluation|nmod|value Determination|dep|evaluation Determination|nmod|amplification amplification|amod|END_ENTITY	Determination of c-myc amplification and overexpression in breast_cancer patients : evaluation of its prognostic value against c-erbB-2 , cathepsin-D and clinicopathological characteristics using univariate and multivariate analysis .
1348967	0	c-erbB-2	7,15	c-myc	0,5	c-erbB-2	c-myc	2064	4609	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	c-myc , c-erbB-2 , and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast_carcinoma .
1349907	0	c-erbB-2	60,68	c-myc	70,75	c-erbB-2	c-myc	2064	4609	Gene	Gene	p21|amod|START_ENTITY p21|amod|END_ENTITY	Preliminary study on oncogene product immunohistochemistry -LRB- c-erbB-2 , c-myc , ras p21 , EGFR -RRB- in breast pathology .
7780818	0	c-erbB-2	22,30	c-myc	15,20	c-erbB-2	c-myc	2064	4609	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	-LSB- Expression of c-myc , c-erbB-2 , insulin-like growth factor II andepidermal growth factor receptor in hepatitis_B , cirrhosis and hepatocellular_carcinoma -RSB- .
8096798	0	c-erbB-2	34,42	c-myc	17,22	c-erbB-2	c-myc	2064	4609	Gene	Gene	not|advcl|START_ENTITY END_ENTITY|neg|not	Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast_cancer .
1349034	0	c-erbB-2	52,60	epidermal_growth_factor_receptor	87,119	c-erbB-2	epidermal growth factor receptor	2064	1956	Gene	Gene	oncoprotein|amod|START_ENTITY oncoprotein|nmod|END_ENTITY	Human breast_cancer : prognostic significance of the c-erbB-2 oncoprotein compared with epidermal_growth_factor_receptor , DNA ploidy , and conventional pathologic features .
12088102	0	c-erbB-2	14,22	estrogen_receptor	78,95	c-erbB-2	estrogen receptor	2064	2099	Gene	Gene	Expression|nmod|START_ENTITY correlate|nsubj|Expression correlate|nmod|status status|compound|END_ENTITY	Expression of c-erbB-2 in node negative breast_cancer does not correlate with estrogen_receptor status , predictors of hormone responsiveness , or PCNA expression .
12598915	0	c-erbB-2	54,62	estrogen_receptor	24,41	c-erbB-2	estrogen receptor	2064	2099	Gene	Gene	overexpression|amod|START_ENTITY END_ENTITY|dobj|overexpression	Angiogenesis relates to estrogen_receptor negativity , c-erbB-2 overexpression and early relapse in node-negative ductal_carcinoma_of_the_breast .
8449602	0	c-erbB-2	111,119	int-2	0,5	c-erbB-2	int-2	2064	2248	Gene	Gene	amplification|acl|START_ENTITY survival|nmod|amplification association|nmod|survival amplification|dep|association amplification|amod|END_ENTITY	int-2 amplification in breast_cancer : association with decreased survival and relationship to amplification of c-erbB-2 and c-myc .
10619912	0	c-erbB-2	33,41	neu	42,45	c-erbB-2	neu	2064	2064	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Gastric_carcinoma : expression of c-erbB-2 / neu oncoprotein , epidermal_growth_factor_receptor , cathepsin_D , progesterone receptor and tumor associated glycoprotein-72 in different histological types .
2470827	0	c-erbB-2	21,29	neu	16,19	c-erbB-2	neu	2064	2064	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Distribution of neu -LRB- c-erbB-2 -RRB- protein in human skin .
3299059	0	c-erbB-2	26,34	neu	21,24	c-erbB-2	neu	2064	2064	Gene	Gene	oncogene|dep|START_ENTITY oncogene|compound|END_ENTITY	Amplification of the neu -LRB- c-erbB-2 -RRB- oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene .
7870438	0	c-erbB-2	0,8	neu	9,12	c-erbB-2	neu	2064	2064	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	c-erbB-2 / neu oncogene and Ki-67 analysis in the assessment of palatal salivary_gland_neoplasms .
8883464	0	c-erbB-2	0,8	neu	9,12	c-erbB-2	neu	2064	2064	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	c-erbB-2 / neu protein expression , DNA ploidy and S phase in breast_cancer .
12839671	0	c-erbB-2	19,27	nm23	50,54	c-erbB-2	nm23	2064	4830	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	-LSB- Overexpression of c-erbB-2 and hypoexpression of nm23 relating to poor prognosis of colorectal_carcinoma -RSB- .
12419164	0	c-erbB-2	64,72	p185	73,77	c-erbB-2	p185	13866(Tax:10090)	66515(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	Development and identification of monoclonal antibodies against c-erbB-2 p185 intracellular domain .
1350198	0	c-erbB-2	22,30	p185	43,47	c-erbB-2	p185	2064	8661	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|dep|protein protein|amod|END_ENTITY	Overexpression of the c-erbB-2 / neu-encoded p185 protein in primary lung_cancer .
2571966	0	c-erbB-2	18,26	p185	41,45	c-erbB-2	p185	2064	8661	Gene	Gene	product|amod|START_ENTITY Expression|nmod|product Expression|appos|END_ENTITY	Expression of the c-erbB-2 gene product -LRB- p185 -RRB- at different stages of neoplastic progression in the colon .
9796989	0	c-erbB-2	78,86	p185	24,28	c-erbB-2	p185	2064	8661	Gene	Gene	anti-p185|dep|START_ENTITY determines|xcomp|anti-p185 determines|nsubj|density density|nmod|END_ENTITY	Cell surface density of p185 -LRB- c-erbB-2 -RRB- determines susceptibility to anti-p185 -LRB- c-erbB-2 -RRB- - ricin A chain -LRB- RTA -RRB- immunotoxin therapy alone and in combination with anti-p170 -LRB- EGFR -RRB- - RTA in ovarian_cancer cells .
9852307	0	c-erbB-2	96,104	p185	0,4	c-erbB-2	p185	2064	8661	Gene	Gene	amplification|amod|START_ENTITY comparison|nmod|amplification overexpression|dep|comparison overexpression|amod|END_ENTITY	p185 overexpression in 220 samples of breast_cancer undergoing primary surgery : comparison with c-erbB-2 gene amplification .
10355531	0	c-erbB-2	44,52	p53	22,25	c-erbB-2	p53	2064	7157	Gene	Gene	Positive|nmod|START_ENTITY Positive|nmod|END_ENTITY	Positive staining for p53 and expression of c-erbB-2 in endosalpinx hyperplasia : analysis of 48 cases and review of literature .
10502729	0	c-erbB-2	78,86	p53	153,156	c-erbB-2	p53	2064	7157	Gene	Gene	amplification|amod|START_ENTITY amplification|acl|detected detected|nmod|accumulation accumulation|compound|END_ENTITY	Genetic alterations in early-onset invasive breast_carcinomas : correlation of c-erbB-2 amplification detected by fluorescence in situ hybridization with p53 accumulation and tumor phenotype .
10621852	0	c-erbB-2	99,107	p53	26,29	c-erbB-2	p53	2064	7157	Gene	Gene	neu|amod|START_ENTITY neu|compound|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
10628345	0	c-erbB-2	0,8	p53	10,13	c-erbB-2	p53	2064	7157	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	c-erbB-2 , p53 protein expression and steroid hormone receptors in breast_carcinomas : an immunohistochemical study .
11240767	0	c-erbB-2	42,50	p53	31,34	c-erbB-2	p53	2064	7157	Gene	Gene	significance|amod|START_ENTITY significance|nmod|END_ENTITY	The prognostic significance of p53 , mdm2 , c-erbB-2 , cathepsin_D , and thrombocytosis in stage_IB_cervical_cancer treated by primary radical hysterectomy .
11819564	0	c-erbB-2	44,52	p53	29,32	c-erbB-2	p53	2064	7157	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Immunohistochemical study on p53 , H-rasp21 , c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients .
12515910	1	c-erbB-2	154,162	p53	130,133	c-erbB-2	p53	2064	7157	Gene	Gene	Correlation|amod|START_ENTITY Correlation|nmod|expression expression|compound|END_ENTITY	Correlation with p53 protein expression , c-erbB-2 , hormone receptors ' status and proliferative activity .
12760717	0	c-erbB-2	67,75	p53	62,65	c-erbB-2	p53	2064	7157	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Helicobacter_pylori_infection affects the expression of PCNA , p53 , c-erbB-2 and Bcl-2 in the human gastric mucosa .
1370701	0	c-erbB-2	5,13	p53	0,3	c-erbB-2	p53	2064	7157	Gene	Gene	epidermal_growth_factor_receptor|amod|START_ENTITY END_ENTITY|appos|epidermal_growth_factor_receptor	p53 , c-erbB-2 and the epidermal_growth_factor_receptor in the benign and malignant prostate .
14598611	0	c-erbB-2	170,178	p53	146,149	c-erbB-2	p53	2064	7157	Gene	Gene	correlation|appos|START_ENTITY correlation|appos|genes genes|dep|END_ENTITY	Immunohistochemical study of apoptosis-related Bcl-2 protein and its correlation with proliferation indices -LRB- Ki67 , PCNA -RRB- , tumor suppressor genes -LRB- p53 , pRb -RRB- , the oncogene c-erbB-2 , sex steroid hormone receptors and other clinicopathological features , in normal , hyperplastic and neoplastic endometrium .
7847827	0	c-erbB-2	53,61	p53	14,17	c-erbB-2	p53	2064	7157	Gene	Gene	proliferation|amod|START_ENTITY Expression|appos|proliferation Expression|nmod|gene gene|compound|END_ENTITY	Expression of p53 tumor suppressor gene , oncoprotein c-erbB-2 , cellular proliferation and differentiation in malignant and benign pancreatic lesions .
7906245	0	c-erbB-2	60,68	p53	70,73	c-erbB-2	p53	2064	7157	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Lymphoepithelioma-like_carcinoma of the uterine cervix with c-erbB-2 , p53 oncoprotein expression and DNA quantification .
7911025	0	c-erbB-2	46,54	p53	33,36	c-erbB-2	p53	2064	7157	Gene	Gene	protein|amod|START_ENTITY detection|appos|protein detection|nmod|protein protein|compound|END_ENTITY	Immunohistochemical detection of p53 protein , c-erbB-2 protein , epidermal_growth_factor_receptor protein and proliferating_cell_nuclear_antigen in gastric_carcinoma .
8102517	0	c-erbB-2	0,8	p53	29,32	c-erbB-2	p53	2064	7157	Gene	Gene	oncogene|amod|START_ENTITY related|nsubj|oncogene related|nmod|expression expression|compound|END_ENTITY	c-erbB-2 oncogene related to p53 expression , cell proliferation and prognosis in breast_cancer .
9042263	0	c-erbB-2	53,61	p53	20,23	c-erbB-2	p53	2064	7157	Gene	Gene	proteins|amod|START_ENTITY correlated|nmod|proteins correlated|nsubj|overexpression overexpression|compound|END_ENTITY	Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin_D proteins in colorectal_cancer .
9167896	0	c-erbB-2	68,76	p53	88,91	c-erbB-2	p53	2064	7157	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Flow cytometric cell cycle kinetics and quantitative measurement of c-erbB-2 and mutant p53 proteins in normal , hyperplastic , and malignant endometrial biopsies .
9387534	0	c-erbB-2	15,23	p53	49,52	c-erbB-2	p53	2064	7157	Gene	Gene	oncogene|amod|START_ENTITY Expression|nmod|oncogene Expression|nmod|gene gene|compound|END_ENTITY	-LSB- Expression of c-erbB-2 oncogene and mutation of p53 gene in myoepithelioma and myoepithelial_carcinoma -RSB- .
9413200	0	c-erbB-2	5,13	p53	0,3	c-erbB-2	p53	2064	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	p53 , c-erbB-2 and p21ras expression in tumor effusion cells of patients with histopathologically different ovarian_neoplasms .
9458364	0	c-erbB-2	22,30	p53	44,47	c-erbB-2	p53	2064	7157	Gene	Gene	model|amod|START_ENTITY model|amod|b72 b72|dep|.3 .3|nummod|END_ENTITY	Altered expression of c-erbB-2 , DF3 , b72 .3 , p53 and Ki-67 with progression and differentiation to two distinct histologic types of invasive_carcinoma in the MCF10AT human xenograft model of proliferative_breast_disease .
9819502	0	c-erbB-2	103,111	p53	64,67	c-erbB-2	p53	2064	7157	Gene	Gene	immunostaining|amod|START_ENTITY immunostaining|compound|END_ENTITY	Prognostic evaluation in supratentorial_astrocytic_tumors using p53 , epidermal_growth_factor_receptor , c-erbB-2 immunostaining .
14687787	0	c-erbB-2	18,26	vascular_endothelial_growth_factor	64,98	c-erbB-2	vascular endothelial growth factor	2064	7422	Gene	Gene	Overexpression|nmod|START_ENTITY related|nsubjpass|Overexpression related|nmod|expression expression|nmod|END_ENTITY	Overexpression of c-erbB-2 is related to a higher expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and constitutes an independent prognostic factor in primary node-positive_breast_cancer after adjuvant systemic treatment .
10537356	0	c-erbB-3	18,26	HER-3	27,32	c-erbB-3	HER-3	2065	2065	Gene	Gene	receptors|amod|START_ENTITY receptors|dep|END_ENTITY	Expression of the c-erbB-3 / HER-3 and c-erbB-4 / HER-4 growth factor receptors and their ligands , neuregulin-1 alpha , neuregulin-1 beta , and betacellulin , in normal endometrium and endometrial_cancer .
11417974	0	c-erbB2	5,12	HER2	13,17	c-erbB2	HER2	2064	2064	Gene	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	Does c-erbB2 / HER2 overexpression predict adjuvant tamoxifen failure in patients with early breast_cancer ?
9307054	0	c-erbB2	55,62	NEU	63,66	c-erbB2	NEU	2064	2064	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Estrogens and glucocorticoids induce the expression of c-erbB2 / NEU receptor in Ishikawa human endometrial cells .
10408862	0	c-erbB2	0,7	neu	8,11	c-erbB2	neu	2064	2064	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	c-erbB2 / neu gene and chromosome 17 analysis in breast_cancer by FISH on archival cytological fine-needle aspirates .
11422380	0	c-erbB2	20,27	neu	28,31	c-erbB2	neu	2064	2064	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Transfection of the c-erbB2 / neu gene upregulates the expression of sialyl_Lewis_X , alpha1,3-fucosyltransferase VII , and metastatic potential in a human hepatocarcinoma cell line .
10641149	0	c-erbb-2	37,45	p53	90,93	c-erbb-2	p53	2064	7157	Gene	Gene	oncoprotein|amod|START_ENTITY co-expression|nmod|oncoprotein co-expression|appos|suppressor suppressor|appos|END_ENTITY	Immunohistochemical co-expression of c-erbb-2 / Neu oncoprotein , altered tumour suppressor -LRB- p53 -RRB- protein , EGF-R and EMA in histological subtypes of infiltrating_duct_carcinoma of the breast .
8753773	0	c-fgr	36,41	CD24	15,19	c-fgr	CD24	2268	100133941	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CD24 with the kinase c-fgr in a small_cell_lung_cancer cell line and with the kinase lyn in an erythroleukemia cell line .
1374350	0	c-fms	20,25	CSF-1	14,19	c-fms	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY Expression|dep|mRNA Expression|nmod|END_ENTITY	Expression of CSF-1 / c-fms and SF/c-kit mRNA during preimplantation mouse development .
2826201	0	c-fms	76,81	CSF-1	20,25	c-fms	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	responsiveness|nmod|START_ENTITY responsiveness|compound|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
2962881	0	c-fms	76,81	CSF-1	20,25	c-fms	CSF-1	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	responsiveness|nmod|START_ENTITY responsiveness|compound|END_ENTITY	Correlation between CSF-1 responsiveness and expression of -LRB- CSF-1_receptor -RRB- c-fms in purified murine granulocyte-macrophage progenitor cells -LRB- CFU-GM -RRB- .
2143208	0	c-fms	14,19	IL-2	0,4	c-fms	IL-2	1436	3558	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	IL-2 enhances c-fms expression in human monocytes .
9852586	0	c-fms	48,53	M-CSF	69,74	c-fms	M-CSF	12978(Tax:10090)	12977(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Expression pattern and neurotrophic role of the c-fms proto-oncogene M-CSF receptor in rodent Purkinje cells .
16482219	0	c-fms	52,57	Pax5	66,70	c-fms	Pax5	1436	5079	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction .
9388498	0	c-fms	36,41	Tumor_necrosis_factor-alpha	0,27	c-fms	Tumor necrosis factor-alpha	12978(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces c-fms RNA expression in murine tissue macrophages .
11573203	0	c-fms	71,76	VCAM-1	89,95	c-fms	VCAM-1	12978(Tax:10090)	22329(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Detection of murine adult bone marrow stroma-initiating cells in Lin -LRB- - -RRB- c-fms -LRB- + -RRB- c-kit -LRB- low -RRB- VCAM-1 -LRB- + -RRB- cells .
11573203	0	c-fms	71,76	c-kit	79,84	c-fms	c-kit	12978(Tax:10090)	16590(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Detection of murine adult bone marrow stroma-initiating cells in Lin -LRB- - -RRB- c-fms -LRB- + -RRB- c-kit -LRB- low -RRB- VCAM-1 -LRB- + -RRB- cells .
9345035	0	c-fms	79,84	c-kit	93,98	c-fms	c-kit	1436	3815	Gene	Gene	START_ENTITY|dep|dependent dependent|amod|END_ENTITY	Development of osteoclasts from embryonic_stem cells through a pathway that is c-fms but not c-kit dependent .
7964503	0	c-fms	173,178	colony-stimulating_factor-1_receptor	135,171	c-fms	colony-stimulating factor-1 receptor	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Opposing actions of c-ets/PU .1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating_factor-1_receptor -LRB- c-fms -RRB- genes .
9710599	0	c-fms	140,145	p42	59,62	c-fms	p42	1436	23552	Gene	Gene	kinases|nmod|START_ENTITY kinases|dobj|END_ENTITY	Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating_factor_1 / c-fms signaling .
17332318	0	c-fms	182,187	transforming_growth_factor-beta1	137,169	c-fms	transforming growth factor-beta1	1436	7040	Gene	Gene	inducing|dobj|START_ENTITY END_ENTITY|advcl|inducing	Elevated expression of the oncogene c-fms and its ligand , the macrophage colony-stimulating factor-1 , in cervical cancer and the role of transforming_growth_factor-beta1 in inducing c-fms expression .
10225363	0	c-fos	42,47	5-HT1B	5,11	c-fos	5-HT1B	314322(Tax:10116)	25075(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression modulate|nsubj|END_ENTITY	Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis .
8526913	0	c-fos	37,42	Adrenomedullin	0,14	c-fos	Adrenomedullin	314322(Tax:10116)	25026(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Adrenomedullin induces expression of c-fos and AP-1 activity in rat vascular smooth muscle cells and cardiomyocytes .
2737716	0	c-fos	23,28	Angiotensin_II	0,14	c-fos	Angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces c-fos expression in smooth muscle via transcriptional control .
2827679	0	c-fos	41,46	Angiotensin_II	0,14	c-fos	Angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces expression of the c-fos gene through protein kinase C activation and calcium ion mobilization in cultured vascular smooth muscle cells .
2909538	0	c-fos	23,28	Angiotensin_II	0,14	c-fos	Angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY induces|dobj|mRNA induces|nsubj|END_ENTITY	Angiotensin_II induces c-fos mRNA in aortic smooth muscle .
7539537	0	c-fos	31,36	Angiotensin_II	0,14	c-fos	Angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|nmod|expression induces|nsubj|END_ENTITY	Angiotensin_II induces in vivo c-fos expression from rat renal cortex and medulla .
7581259	0	c-fos	41,46	Angiotensin_II	0,14	c-fos	Angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY expression|nmod|mRNA induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces the expression of c-fos mRNA in the central nervous system of the rat .
7784900	0	c-fos	24,29	Angiotensin_II	1,15	c-fos	Angiotensin II	2353	183	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	-LSB- Angiotensin_II induces c-fos and c-myc proto-oncogene expression in the left ventricle -RSB- .
8058201	0	c-fos	39,44	Basic_fibroblast_growth_factor	0,30	c-fos	Basic fibroblast growth factor	314322(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces c-fos expression in primary cultures of rat striatum .
9419976	0	c-fos	15,20	Bcl-2	0,5	c-fos	Bcl-2	14281(Tax:10090)	12043(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Bcl-2 inhibits c-fos induction by calcium .
12853419	0	c-fos	0,5	CA1	103,106	c-fos	CA1	314322(Tax:10116)	310218(Tax:10116)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|expression expression|nmod|region region|compound|END_ENTITY	c-fos reduces corticosterone-mediated effects on neurotrophic_factor expression in the rat hippocampal CA1 region .
7623110	0	c-fos	11,16	CA1	133,136	c-fos	CA1	314322(Tax:10116)	310218(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Changes|nmod|expression Changes|dep|involvement involvement|nmod|END_ENTITY	Changes in c-fos mRNA expression in rat brain during odor discrimination learning : differential involvement of hippocampal subfields CA1 and CA3 .
16530956	0	c-fos	0,5	CA3	87,90	c-fos	CA3	14281(Tax:10090)	12350(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	c-fos modulates brain-derived_neurotrophic_factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons .
1415544	0	c-fos	39,44	CCK	0,3	c-fos	CCK	314322(Tax:10116)	25298(Tax:10116)	Gene	Gene	stimulate|dobj|START_ENTITY stimulate|nsubj|END_ENTITY	CCK , bombesin , and carbachol stimulate c-fos , c-jun , and c-myc oncogene expression in rat pancreatic acini .
12137955	0	c-fos	37,42	CREB	114,118	c-fos	CREB	2353	1385	Gene	Gene	promoter|amod|START_ENTITY induction|nmod|promoter mediated|nsubjpass|induction mediated|nmod|elements elements|appos|END_ENTITY	Ultraviolet B -LRB- UVB -RRB- induction of the c-fos promoter is mediated by phospho-cAMP_response_element_binding_protein -LRB- CREB -RRB- binding to CRE and c-fos activator protein 1 site -LRB- FAP1 -RRB- cis elements .
12432566	0	c-fos	37,42	CREB	8,12	c-fos	CREB	2353	1385	Gene	Gene	activation|amod|START_ENTITY Role|nmod|activation Role|nmod|factor factor|compound|END_ENTITY	Role of CREB transcription factor in c-fos activation in natural killer cells .
20574536	0	c-fos	14,19	CREB	55,59	c-fos	CREB	14281(Tax:10090)	12912(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY promoter|acl:relcl|responds responds|nmod|END_ENTITY	A novel mouse c-fos intronic promoter that responds to CREB and AP-1 is developmentally regulated in vivo .
2157471	0	c-fos	43,48	CREB	107,111	c-fos	CREB	2353	1385	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB .
22079318	0	c-fos	79,84	CREB	52,56	c-fos	CREB	314322(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY A-CREB|nmod|expression A-CREB|appos|inhibitor inhibitor|nmod|END_ENTITY	Effects of A-CREB , a dominant negative inhibitor of CREB , on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo .
8205620	0	c-fos	77,82	CREB	120,124	c-fos	CREB	2353	1385	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB .
8574661	0	c-fos	21,26	CREB	92,96	c-fos	CREB	314322(Tax:10116)	81646(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|phosphorylation phosphorylation|appos|END_ENTITY	Nitric_oxide induces c-fos gene expression via cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- phosphorylation in rat retinal_pigment_epithelium .
9030636	0	c-fos	117,122	CREB	40,44	c-fos	CREB	314322(Tax:10116)	81646(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY relationship|nmod|induction Phosphorylation|dep|relationship Phosphorylation|nmod|END_ENTITY	Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia : relationship to c-fos induction .
9447994	0	c-fos	115,120	CREB	33,37	c-fos	CREB	314322(Tax:10116)	81646(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY mediator|nmod|transcription reveals|ccomp|mediator reveals|nsubj|inhibitor inhibitor|nmod|END_ENTITY	A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos .
9770464	0	c-fos	117,122	CREB	83,87	c-fos	CREB	2353	1385	Gene	Gene	gene|amod|START_ENTITY protein|nmod|gene protein|compound|END_ENTITY	Rsk-2 activity is necessary for epidermal_growth_factor-induced phosphorylation of CREB protein and transcription of c-fos gene .
9850145	0	c-fos	11,16	CREB	74,78	c-fos	CREB	14281(Tax:10090)	12912(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|middle_cerebral_artery_occlusion middle_cerebral_artery_occlusion|nmod|mice mice|compound|END_ENTITY	Attenuated c-fos mRNA induction after middle_cerebral_artery_occlusion in CREB knockout mice does not modulate focal ischemic_injury .
8930307	0	c-fos	60,65	CRF	24,27	c-fos	CRF	314322(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Intracerebroventricular CRF inhibits cold restraint-induced c-fos expression in the dorsal motor nucleus of the vagus and gastric_erosions in rats .
9541255	0	c-fos	41,46	CSF-1	10,15	c-fos	CSF-1	314322(Tax:10116)	78965(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of CSF-1 on in vivo expression of c-fos in the dental follicle during tooth eruption .
1371708	0	c-fos	24,29	Cholecystokinin	0,15	c-fos	Cholecystokinin	314322(Tax:10116)	25298(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Cholecystokinin induces c-fos expression in hypothalamic oxytocinergic neurons projecting to the dorsal vagal complex .
15123357	0	c-fos	40,45	Connective_tissue_growth_factor	0,31	c-fos	Connective tissue growth factor	314322(Tax:10116)	64032(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Connective_tissue_growth_factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells .
8264665	0	c-fos	41,46	Corticotropin-releasing_factor	0,30	c-fos	Corticotropin-releasing factor	314322(Tax:10116)	81648(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Corticotropin-releasing_factor activates c-fos , NGFI-B , and corticotropin-releasing_factor gene expression within the paraventricular nucleus of the rat hypothalamus .
7637573	0	c-fos	69,74	D1_receptor	88,99	c-fos	D1 receptor	14281(Tax:10090)	13488(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|activation activation|amod|END_ENTITY	Dopaminergic control of gene transcription during striatal ontogeny : c-fos induction by D1_receptor activation in the developing striosomes .
19619587	0	c-fos	10,15	Dyt1	105,109	c-fos	Dyt1	14281(Tax:10090)	30931(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Increased c-fos expression in the central nucleus of the amygdala and enhancement of cued fear memory in Dyt1 DeltaGAG knock-in mice .
12953797	0	c-fos	82,87	ERK	162,165	c-fos	ERK	14281(Tax:10090)	26413(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Suppressive effect of taurine on platelet-derived growth factor -LRB- PDGF -RRB- BB-induced c-fos and c-jun mRNA expressions through extracellular_signal-regulated_kinase -LRB- ERK -RRB- in mesenchymal cell lines .
11972170	0	c-fos	44,49	ET-1	1,5	c-fos	ET-1	314322(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	-LSB- ET-1 induces the expression of prooncogene c-fos in cultured neonatal rat myocardial cells -RSB- .
10503767	0	c-fos	24,29	Endothelin-1	0,12	c-fos	Endothelin-1	2353	1906	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates c-fos mRNA expression in C6_glioma cells via MAP kinase pathway .
1314585	0	c-fos	24,29	Endothelin-1	0,12	c-fos	Endothelin-1	314322(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates c-fos mRNA expression and acts as a modulator on cell proliferation of rat FRTL5 thyroid cells .
25016214	0	c-fos	79,84	Endothelin-1	0,12	c-fos	Endothelin-1	2353	1906	Gene	Gene	dependent|advmod|START_ENTITY dependent|nsubj|proliferation proliferation|amod|driven driven|advmod|END_ENTITY	Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent .
3071340	0	c-fos	58,63	GM-CSF	8,14	c-fos	GM-CSF	2353	1437	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of GM-CSF in phagocyte recruitment and regulation of c-fos protooncogene expression .
8243334	0	c-fos	23,28	GT1	43,46	c-fos	GT1	2353	2683	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Autocrine induction of c-fos expression in GT1 neuronal cells by gonadotropin-releasing_hormone .
9950815	0	c-fos	16,21	Gastrin	0,7	c-fos	Gastrin	314322(Tax:10116)	25320(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	Gastrin induces c-fos gene transcription via multiple signaling pathways .
7492677	1	c-fos	150,155	GnRH_receptor	126,139	c-fos	GnRH receptor	2353	2798	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	Characterization of changes in GnRH_receptor -LRB- GnRH-R -RRB- , c-fos , and c-jun messenger ribonucleic acids during the ovine estrous cycle .
1396336	0	c-fos	64,69	Growth_hormone	0,14	c-fos	Growth hormone	2353	2688	Gene	Gene	transcription|amod|START_ENTITY inducing|dobj|transcription synergizes|advcl|inducing synergizes|nsubj|END_ENTITY	Growth_hormone synergizes with serum growth factors in inducing c-fos transcription in 3T3-F442A cells .
1547725	0	c-fos	23,28	Growth_hormone	0,14	c-fos	Growth hormone	2353	2688	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Growth_hormone induces c-fos and c-jun expression in cells with varying requirements for differentiation .
2493151	0	c-fos	26,31	Growth_hormone	0,14	c-fos	Growth hormone	2353	2688	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Growth_hormone stimulates c-fos gene expression by means of protein kinase C without increasing inositol lipid turnover .
7988469	0	c-fos	41,46	Growth_hormone	0,14	c-fos	Growth hormone	314322(Tax:10116)	81668(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene induces|dobj|expression induces|nsubj|END_ENTITY	Growth_hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats .
3135482	0	c-fos	40,45	Growth_hormone-releasing_factor	0,31	c-fos	Growth hormone-releasing factor	2353	2691	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Growth_hormone-releasing_factor induces c-fos expression in cultured primary pituitary cells .
3355549	0	c-fos	16,21	IGF-I	0,5	c-fos	IGF-I	314322(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	IGF-I increases c-fos expression in FRTL5 rat thyroid cells by activating the c-fos promoter .
1305903	0	c-fos	12,17	IL-2	45,49	c-fos	IL-2	14281(Tax:10090)	16183(Tax:10090)	Gene	Gene	augments|nsubj|START_ENTITY augments|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	Deregulated c-fos augments the expression of IL-2 gene in T cells stimulated with anti-CD3 antibody .
1918970	0	c-fos	0,5	IL-2	36,40	c-fos	IL-2	14281(Tax:10090)	16183(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	c-fos transcriptional activation by IL-2 in mouse CTL-L2 cells is mediated through two distinct signal transduction pathways converging on the same enhancer element .
7560451	0	c-fos	97,102	IL-2	147,151	c-fos	IL-2	14281(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|sensitivity sensitivity|nmod|END_ENTITY	Differential cell - and immuno-biological properties of murine B16-F1 and F10 melanomas : oncogene c-fos expression , sensitivity to LAK cells and/or IL-2 , and components of gangliosides .
7568005	0	c-fos	99,104	IL-2	36,40	IL-2R	IL-2	3559	3558	Gene	Gene	induction|amod|START_ENTITY gamma-chain-associated|nmod|induction gamma-chain-associated|nsubj|role role|nmod|receptor receptor|appos|END_ENTITY	Critical role of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc , but not bcl-2 , gene induction .
7930571	0	c-fos	36,41	IL-2	12,16	c-fos	IL-2	14281(Tax:10090)	16183(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Analysis of IL-2 gene regulation in c-fos transgenic_mice .
8468462	1	c-fos	134,139	IL-2	89,93	c-fos	IL-2	2353	3558	Gene	Gene	synthesis|amod|START_ENTITY correlates|nmod|synthesis correlates|nsubj|transcription transcription|compound|END_ENTITY	Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1 .
9027322	0	c-fos	39,44	IL-2	15,19	c-fos	IL-2	2353	3558	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|Interleukin-2 Interleukin-2|appos|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- and IL-6 regulate c-fos protooncogene expression in human pituitary_adenoma explants .
10512366	0	c-fos	63,68	INS-1	113,118	c-fos	INS-1	314322(Tax:10116)	24505(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic beta-cell line INS-1 .
8225387	0	c-fos	12,17	IgG2b	28,33	c-fos	IgG2b	14281(Tax:10090)	16016(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|production production|amod|END_ENTITY	Deregulated c-fos modulates IgG2b production of B cells mediated by lipopolysaccharide .
8348296	0	c-fos	72,77	Interleukin-1_beta	0,18	c-fos	Interleukin-1 beta	314322(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-1_beta inhibits the endogenous expression of the early gene c-fos located within the nucleus of LH-RH neurons and interferes with hypothalamic LH-RH release during proestrus in the rat .
9027322	0	c-fos	39,44	Interleukin-2	0,13	c-fos	Interleukin-2	2353	3558	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- and IL-6 regulate c-fos protooncogene expression in human pituitary_adenoma explants .
9930727	0	c-fos	14,19	JNK	57,60	c-fos	JNK	2353	5599	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of c-fos , c-jun , and c-jun_N-terminal_kinase -LRB- JNK -RRB- in a developmental model of induced apoptotic death in neurons of the substantia nigra .
11817569	0	c-fos	41,46	NF-kappaB	22,31	c-fos	NF-kappaB	14281(Tax:10090)	18033(Tax:10090)	Gene	Gene	/|dobj|START_ENTITY /|nsubj|factors factors|amod|END_ENTITY	Transcription factors NF-kappaB and AP-1 / c-fos in cell response to nocodazole .
18762893	0	c-fos	191,196	NF-kappaB	158,167	c-fos	NF-kappaB	14281(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Effect of thermal_injury on LPS-mediated Toll signaling pathways by murine peritoneal macrophages : inhibition of DNA-binding of transcription factor AP-1 and NF-kappaB and gene expression of c-fos and IL-12p40 .
11324543	0	c-fos	49,54	Neurokinin-1_receptor	1,22	c-fos	Neurokinin-1 receptor	314322(Tax:10116)	24807(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mediated|dobj|expression mediated|nsubj|END_ENTITY	-LSB- Neurokinin-1_receptor mediated formalin-induced c-fos expression in the rat spinal cord -RSB- .
25057795	0	c-fos	21,26	Neurokinin_B	0,12	c-fos	Neurokinin B	14281(Tax:10090)	6866	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	Neurokinin_B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons .
3277634	0	c-fos	16,21	ODC	27,30	c-fos	ODC	314322(Tax:10116)	24609(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene .
17235455	0	c-fos	37,42	PTEN	0,4	c-fos	PTEN	2353	5728	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway .
12210735	0	c-fos	8,13	PTH	70,73	c-fos	PTH	2353	5741	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP : localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer .
15476581	0	c-fos	149,154	PTH	66,69	c-fos	PTH	14281(Tax:10090)	19226(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY increase|nmod|mRNA inhibition|nmod|increase alleviates|nmod|inhibition alleviates|dobj|action action|nmod|END_ENTITY	Skeletal unloading alleviates the anabolic action of intermittent PTH -LRB- 1-34 -RRB- in mouse tibia in association with inhibition of PTH-induced increase in c-fos mRNA in bone marrow cells .
19419301	0	c-fos	136,141	PTH	13,16	c-fos	PTH	14281(Tax:10090)	19226(Tax:10090)	Gene	Gene	formation|nmod|START_ENTITY leading|nmod|formation mice|amod|leading stimulates|nmod|mice stimulates|nsubj|administration administration|compound|END_ENTITY	Intermittent PTH administration stimulates pre-osteoblastic proliferation without leading to enhanced bone formation in osteoclast-less c-fos -LRB- - / - -RRB- mice .
7962120	0	c-fos	30,35	PTH	75,78	c-fos	PTH	2353	5741	Gene	Gene	induction|amod|START_ENTITY signaling|nmod|induction signaling|nmod|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Second messenger signaling of c-fos gene induction by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide in osteoblastic_osteosarcoma cells : its role in osteoblast proliferation and osteoclast-like cell formation .
9389528	0	c-fos	15,20	PTH	76,79	c-fos	PTH	14281(Tax:10090)	19226(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|parathyroid_hormone parathyroid_hormone|appos|END_ENTITY	Proto-oncogene c-fos is transcriptionally regulated by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein in a cyclic_adenosine_monophosphate-dependent manner in osteoblastic cells .
1480173	0	c-fos	28,33	Parathyroid_hormone	0,19	c-fos	Parathyroid hormone	314322(Tax:10116)	24694(Tax:10116)	Gene	Gene	RNA|amod|START_ENTITY induces|dobj|RNA induces|nsubj|END_ENTITY	Parathyroid_hormone induces c-fos and c-jun messenger RNA in rat osteoblastic cells .
8275957	0	c-fos	39,44	Parathyroid_hormone	0,19	c-fos	Parathyroid hormone	2353	5741	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Parathyroid_hormone induces sequential c-fos expression in bone cells in vivo : in situ localization of its receptor and c-fos messenger ribonucleic acids .
8810350	0	c-fos	28,33	Parathyroid_hormone	0,19	c-fos	Parathyroid hormone	2353	5741	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Parathyroid_hormone induces c-fos promoter activity in osteoblastic cells through phosphorylated cAMP response element -LRB- CRE -RRB- - binding protein binding to the major CRE .
9351440	0	c-fos	26,31	RhoA	10,14	c-fos	RhoA	2353	387	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Activated RhoA stimulates c-fos gene expression in myocardial cells .
3126735	0	c-fos	29,34	TGF_beta	0,8	c-fos	TGF beta	314322(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF_beta induces a sustained c-fos expression associated with stimulation or inhibition of cell growth in EL2 or NIH 3T3 fibroblasts .
1899225	0	c-fos	12,17	TNF	0,3	c-fos	TNF	14281(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TNF induces c-fos via a novel pathway requiring conversion of arachidonic_acid to a lipoxygenase metabolite .
11689211	0	c-fos	53,58	TNFalpha	0,8	c-fos	TNFalpha	314322(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNFalpha induces expression of transcription factors c-fos , Egr-1 , and Ets-1 in vascular_lesions through extracellular_signal-regulated_kinases_1 / 2 .
2119237	0	c-fos	17,22	Thrombin	0,8	c-fos	Thrombin	2353	2147	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces c-fos expression in cultured human endothelial cells by a Ca2 -LRB- + -RRB- - dependent mechanism .
9515031	0	c-fos	83,88	Transforming_growth_factor-beta1	0,32	c-fos	Transforming growth factor-beta1	314322(Tax:10116)	59086(Tax:10116)	Gene	Gene	element|amod|START_ENTITY activate|dobj|element activate|nsubj|synergistically synergistically|compound|END_ENTITY	Transforming_growth_factor-beta1 and protein kinase C synergistically activate the c-fos serum response element in myocardial cells .
21340818	0	c-fos	13,18	Urokinase-Type_Plasminogen_Activator	38,74	c-fos	Urokinase-Type Plasminogen Activator	2353	5328	Gene	Gene	Expression|amod|START_ENTITY Induction|nmod|Expression Induction|nmod|END_ENTITY	Induction of c-fos Gene Expression by Urokinase-Type_Plasminogen_Activator in Human Ovarian_Cancer Cells .
15189768	0	c-fos	55,60	Urotensin-II	0,12	GPR14	Urotensin-II	2837	29180(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Urotensin-II , a neuropeptide ligand for GPR14 , induces c-fos in the rat brain .
7769693	0	c-fos	34,39	YY1	48,51	c-fos	YY1	2353	7528	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB .
10218987	0	c-fos	88,93	adrenomedullin	23,37	c-fos	adrenomedullin	314322(Tax:10116)	25026(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY induction|nmod|messenger level|nmod|induction increases|dobj|level increases|nsubj|END_ENTITY	Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic_acid in the paraventricular and supraoptic nuclei of the rat .
15224145	0	c-fos	85,90	adrenomedullin	42,56	c-fos	adrenomedullin	314322(Tax:10116)	25026(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|administration administration|nmod|END_ENTITY	Intracerebroventricular administration of adrenomedullin increases the expression of c-fos and activates nitric_oxide-producing neurons in rat cardiovascular related brain nuclei .
21171326	0	c-fos	110,115	adrenomedullin	48,62	c-fos	adrenomedullin	314322(Tax:10116)	25026(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of intracerebroventricular injection of adrenomedullin on catecholaminergic neurons and expression of c-fos in the rat brain nuclei involved in cardiovascular regulation -RSB- .
8394152	0	c-fos	49,54	alpha_MSH	0,9	c-fos	alpha MSH	314322(Tax:10116)	24664(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	alpha_MSH but not Org_2766 induces expression of c-fos in cultured rat spinal cord cells .
11498949	0	c-fos	29,34	angiotensin_II	11,25	c-fos	angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of angiotensin_II on c-fos expression and protein synthesis in cultured rat myocardial cells -RSB- .
17763940	0	c-fos	14,19	angiotensin_II	56,70	c-fos	angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of c-fos , c-jun and c-myc gene expression by angiotensin_II in primary cultured rat astrocytes : role of ERK1/2 MAP kinases .
9839532	0	c-fos	6,11	angiotensin_II	34,48	c-fos	angiotensin II	314322(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Renal c-fos expression induced by angiotensin_II is enhanced in spontaneously hypertensive rats .
9501868	0	c-fos	13,18	basic_fibroblast_growth_factor	48,78	c-fos	basic fibroblast growth factor	314322(Tax:10116)	54250(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of c-fos and c-jun mRNA expression by basic_fibroblast_growth_factor in cultured rat M ller cells .
7563251	0	c-fos	39,44	bcl-2	27,32	c-fos	bcl-2	14281(Tax:10090)	12043(Tax:10090)	Gene	Gene	junB|dep|START_ENTITY junB|compound|END_ENTITY	Differential regulation of bcl-2 , bax , c-fos , junB , and krox-24 expression in the cerebellum of Purkinje_cell_degeneration mutant mice .
10616798	0	c-fos	78,83	brain-derived_neurotrophic_factor	85,118	c-fos	brain-derived neurotrophic factor	314322(Tax:10116)	24225(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Thromboembolic events lead to cortical_spreading_depression and expression of c-fos , brain-derived_neurotrophic_factor , glial fibrillary acidic protein , and heat_shock_protein_70 mRNA in rats .
16530956	0	c-fos	0,5	brain-derived_neurotrophic_factor	16,49	c-fos	brain-derived neurotrophic factor	14281(Tax:10090)	12064(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	c-fos modulates brain-derived_neurotrophic_factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons .
21404708	0	c-fos	59,64	c-Myc	66,71	c-fos	c-Myc	314322(Tax:10116)	24577(Tax:10116)	Gene	Gene	polychlorinated_biphenyl|nmod|START_ENTITY polychlorinated_biphenyl|amod|END_ENTITY	-LSB- Effects of polychlorinated_biphenyl on the expressions of c-fos , c-Myc and beta-catenin in the rat testis -RSB- .
19795350	0	c-fos	33,38	c-fos	69,74	c-fos	c-fos	2353	2353	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of the proto-oncogene c-fos and the immunolocalization of c-fos , phosphorylated c-fos and estrogen_receptor beta in the human testis .
19795350	0	c-fos	69,74	c-fos	33,38	c-fos	c-fos	2353	2353	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of the proto-oncogene c-fos and the immunolocalization of c-fos , phosphorylated c-fos and estrogen_receptor beta in the human testis .
9413158	0	c-fos	56,61	c-fos	74,79	c-fos	c-fos	2353	2353	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Interaction of the Rb tumor suppressor protein with the c-fos promoter in c-fos transfected cells overexpressing c-fos and Rb .
9413158	0	c-fos	74,79	c-fos	56,61	c-fos	c-fos	2353	2353	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Interaction of the Rb tumor suppressor protein with the c-fos promoter in c-fos transfected cells overexpressing c-fos and Rb .
15773551	0	c-fos	60,65	c-jun	67,72	c-fos	c-jun	2353	3725	Gene	Gene	Egr-1|amod|START_ENTITY Egr-1|amod|END_ENTITY	-LSB- Effect of anisomycin on activation of early response genes c-fos , c-jun , Egr-1 in cells transformed by E1A and cHa-ras oncogenes -RSB- .
1667087	0	c-fos	47,52	c-jun	23,28	c-fos	c-jun	2353	3725	Gene	Gene	state|amod|START_ENTITY state|amod|END_ENTITY	Selective induction of c-jun and jun-B but not c-fos or c-myc during mitogenesis in SV40-transformed cells at the predifferentiation growth_arrest state .
24022005	0	c-fos	55,60	c-jun	61,66	c-fos	c-jun	2353	3725	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Barriers to transmission of transcriptional noise in a c-fos c-jun pathway .
7673322	0	c-fos	69,74	c-jun	83,88	c-fos	c-jun	14281(Tax:10090)	16476(Tax:10090)	Gene	Gene	cdc2|amod|START_ENTITY cdc2|amod|END_ENTITY	Cells en route to apoptosis are characterized by the upregulation of c-fos , c-myc , c-jun , cdc2 , and RB phosphorylation , resembling events of early cell-cycle traverse .
9737720	0	c-fos	55,60	c-jun	62,67	c-fos	c-jun	2353	3725	Gene	Gene	START_ENTITY|amod|zif-268 zif-268|amod|END_ENTITY	Glucose and glucoincretin peptides synergize to induce c-fos , c-jun , junB , zif-268 , and nur-77 gene expression in pancreatic beta -LRB- INS-1 -RRB- cells .
1348920	0	c-fos	38,43	c-myc	13,18	c-fos	c-myc	2353	4609	Gene	Gene	Oncoprotein|amod|START_ENTITY Oncoprotein|dep|END_ENTITY	Oncoprotein -LRB- c-myc , c-erbB1 , c-erbB2 , c-fos -RRB- and suppressor gene product -LRB- p53 -RRB- expression in squamous_cell_carcinomas of the lung .
2261575	0	c-fos	46,51	c-myc	25,30	c-fos	c-myc	2353	4609	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Sodium_butyrate inhibits c-myc and stimulates c-fos expression in all the steps of the cell-cycle in hepatoma tissue cultured cells .
3096504	0	c-fos	122,127	c-myc	149,154	c-fos	c-myc	2353	4609	Gene	Gene	oncogene|amod|START_ENTITY oncogene|acl|followed followed|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Stimulation of human lymphocytes by phorbol_acetate and a calcium ionophore induces an early transient expression of the c-fos oncogene followed by c-myc -RSB- .
3144696	0	c-fos	24,29	c-myc	57,62	c-fos	c-myc	314322(Tax:10116)	24577(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|nmod|hepatocytes hepatocytes|amod|END_ENTITY	Transient expression of c-fos and constant expression of c-myc in freshly isolated and cultured normal adult rat hepatocytes .
6334806	0	c-fos	13,18	c-myc	77,82	c-fos	c-myc	2353	4609	Gene	Gene	gene|amod|START_ENTITY Induction|nmod|gene precedes|nsubj|Induction precedes|dobj|activation activation|nmod|END_ENTITY	Induction of c-fos gene and protein by growth factors precedes activation of c-myc .
7866900	0	c-fos	148,153	c-myc	141,146	c-fos	c-myc	2353	4609	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Low-dose recombinant human tumor necrosis-alpha in HL-60 leukemic cell line : effect on induced differentiation and regulating expression of c-myc , c-fos proto-oncogenes -RSB- .
1647033	0	c-fos	83,88	cAMP-responsive_element_modulator	27,60	c-fos	cAMP-responsive element modulator	2353	1390	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Transcriptional antagonist cAMP-responsive_element_modulator -LRB- CREM -RRB- down-regulates c-fos cAMP-induced expression .
8019847	0	c-fos	31,36	corticotropin-releasing_factor	106,136	c-fos	corticotropin-releasing factor	314322(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Water-avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output : role of corticotropin-releasing_factor .
15147776	0	c-fos	55,60	corticotropin-releasing_hormone	79,110	c-fos	corticotropin-releasing hormone	314322(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Effect of naloxone-precipitated morphine withdrawal on c-fos expression in rat corticotropin-releasing_hormone neurons in the paraventricular_hypothalamus and extended amygdala .
1703775	0	c-fos	59,64	cyclic_AMP	108,118	c-fos	cyclic AMP	14281(Tax:10090)	12796(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Multiple synergistic signal transduction pathways regulate c-fos expression in Swiss_3T3 cells : the role of cyclic_AMP .
2500119	0	c-fos	32,37	egr-1	39,44	c-fos	egr-1	2353	1958	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Indomethacin shifts the peak of c-fos , egr-1 , and c-myc gene expression in confluent fibroblasts induced by phorbol_myristate_acetate .
11498983	0	c-fos	9,14	endothelin-1	104,116	c-fos	endothelin-1	2353	1906	Gene	Gene	gene|amod|START_ENTITY Role|nmod|gene induced|nsubj|Role induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Role of c-fos gene in the pulmonary surfactant synthesis of cultured alveolar type II cells induced by endothelin-1 -RSB- .
1331650	0	c-fos	15,20	endothelin-1	122,134	c-fos	endothelin-1	2353	1906	Gene	Gene	expression|amod|START_ENTITY Stimulation|nmod|expression Stimulation|nmod|END_ENTITY	Stimulation of c-fos and c-jun gene expression and down-regulation of proenkephalin gene expression in C6 glioma cells by endothelin-1 .
15086447	0	c-fos	32,37	endothelin-1	46,58	c-fos	endothelin-1	314322(Tax:10116)	24323(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY expression|nmod|mRNA expression|nmod|arteries arteries|amod|END_ENTITY	Force-independent expression of c-fos mRNA by endothelin-1 in rat intact small mesenteric arteries .
8816505	0	c-fos	133,138	endothelin-1	103,115	c-fos	endothelin-1	2353	1906	Gene	Gene	promoter|amod|START_ENTITY propagate|nmod|promoter propagate|nmod|receptors receptors|amod|END_ENTITY	Voltage-insensitive Ca2 + channels and Ca2 + / calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoter .
8524316	0	c-fos	56,61	epidermal_growth_factor	81,104	STAT1	epidermal growth factor	6772	1950	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal_growth_factor .
7935468	0	c-fos	14,19	epidermal_growth_factor_receptor	58,90	c-fos	epidermal growth factor receptor	2353	1956	Gene	Gene	expression|amod|START_ENTITY Activation|nmod|expression Activation|nmod|END_ENTITY	Activation of c-fos gene expression by a kinase-deficient epidermal_growth_factor_receptor .
15196791	0	c-fos	121,126	extracellular_signal-regulated_protein_kinase	152,197	c-fos	extracellular signal-regulated protein kinase	14281(Tax:10090)	26413(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|acl|linked linked|nmod|END_ENTITY	A neuroactive steroid , dehydroepiandrosterone_sulfate , prevents the development of morphine_dependence and tolerance via c-fos expression linked to the extracellular_signal-regulated_protein_kinase .
18479823	0	c-fos	86,91	extracellular_signal-regulated_protein_kinase	15,60	c-fos	extracellular signal-regulated protein kinase	2353	5594	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of extracellular_signal-regulated_protein_kinase in acute cocaine-induced c-fos in nucleus accumbens .
2693038	0	c-fos	38,43	fos	33,36	c-fos	fos	100144486(Tax:9823)	100144486(Tax:9823)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the proto-oncogene fos -LRB- c-fos -RRB- by preimplantation blastocysts of the pig .
19912764	0	c-fos	59,64	gonadotropin_releasing_hormone	11,41	c-fos	gonadotropin releasing hormone	314322(Tax:10116)	25194(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effects of gonadotropin_releasing_hormone and estradiol on c-fos expression in the rat hippocampus .
10027715	0	c-fos	43,48	gp120	6,11	c-fos	gp120	2353	3700	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	HIV-1 gp120 induces the activation of both c-fos and c-jun immediate-early genes in HEL megakaryocytic cells .
8341690	0	c-fos	52,57	growth_hormone	61,75	c-fos	growth hormone	2353	2688	Gene	Gene	induction|nmod|START_ENTITY mediate|dobj|induction mediate|nmod|END_ENTITY	The serum response element can mediate induction of c-fos by growth_hormone .
8462486	0	c-fos	14,19	growth_hormone	49,63	c-fos	growth hormone	2353	2688	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of c-fos proto-oncogene expression by growth_hormone : protein synthesis is not required for down-regulation .
8580424	0	c-fos	13,18	growth_hormone	126,140	c-fos	growth hormone	14281(Tax:10090)	14599(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|nucleus nucleus|nmod|mice mice|nmod|END_ENTITY	Induction of c-fos mRNA in the arcuate nucleus of normal and mutant growth_hormone-deficient mice by a synthetic non-peptidyl growth_hormone secretagogue .
18197392	0	c-fos	34,39	hnRNP-R	0,7	c-fos	hnRNP-R	314322(Tax:10116)	319110(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	hnRNP-R regulates the PMA-induced c-fos expression in retinal cells .
7743197	0	c-fos	14,19	hsp-70	34,40	c-fos	hsp-70	314322(Tax:10116)	266759(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Expression of c-fos and inducible hsp-70 mRNA following a transient episode of focal ischemia that had non-lethal effects on the rat brain .
1549560	0	c-fos	0,5	interleukin_2	24,37	c-fos	interleukin 2	2353	3558	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	c-fos gene induction by interleukin_2 : identification of the critical cytoplasmic regions within the interleukin_2 receptor beta chain .
7568005	0	c-fos	99,104	interleukin_2	21,34	IL-2R	interleukin 2	3559	3558	Gene	Gene	induction|amod|START_ENTITY gamma-chain-associated|nmod|induction gamma-chain-associated|nsubj|role role|nmod|receptor receptor|amod|END_ENTITY	Critical role of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc , but not bcl-2 , gene induction .
9737720	0	c-fos	55,60	junB	69,73	c-fos	junB	2353	3726	Gene	Gene	START_ENTITY|amod|zif-268 zif-268|amod|END_ENTITY	Glucose and glucoincretin peptides synergize to induce c-fos , c-jun , junB , zif-268 , and nur-77 gene expression in pancreatic beta -LRB- INS-1 -RRB- cells .
26122641	0	c-fos	27,32	mTOR	0,4	c-fos	mTOR	2353	21977(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines .
2494062	0	c-fos	80,85	mammary-derived_growth_inhibitor	12,44	c-fos	mammary-derived growth inhibitor	2353	2170	Gene	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	Effect of a mammary-derived_growth_inhibitor on the expression of the oncogenes c-fos , c-myc and c-ras .
23256998	0	c-fos	48,53	miR-181a	22,30	c-fos	miR-181a	2353	387176(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Regulatory effect of miR-181a on expression of c-fos in cochlear hair cells -RSB- .
9121675	0	c-fos	60,65	neurokinin-1_receptor	18,39	c-fos	neurokinin-1 receptor	314322(Tax:10116)	24807(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	A contribution of neurokinin-1_receptor to formalin-induced c-fos expression in the rat spinal dorsal horn .
7988469	0	c-fos	41,46	neuropeptide-Y	68,82	c-fos	neuropeptide-Y	314322(Tax:10116)	24604(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Growth_hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats .
7719725	0	c-fos	0,5	neuropeptide_Y	115,129	c-fos	neuropeptide Y	314322(Tax:10116)	24604(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|nucleus nucleus|nmod|hypothalamus hypothalamus|nmod|infusions infusions|nmod|END_ENTITY	c-fos expression in the paraventricular nucleus of the hypothalamus following intracerebroventricular infusions of neuropeptide_Y .
7895063	0	c-fos	0,5	neuropeptide_Y	70,84	c-fos	neuropeptide Y	314322(Tax:10116)	24604(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|brain brain|nmod|administration administration|nmod|END_ENTITY	c-fos expression in the rat brain following central administration of neuropeptide_Y and effects of food consumption .
8750890	0	c-fos	95,100	neuropeptide_Y	128,142	c-fos	neuropeptide Y	314322(Tax:10116)	24604(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|subpopulation subpopulation|nmod|neurons neurons|amod|END_ENTITY	Central glucoprivation evoked by administration of 2-deoxy-D-glucose induces expression of the c-fos gene in a subpopulation of neuropeptide_Y neurons in the rat hypothalamus .
8782903	0	c-fos	23,28	neuropeptide_Y	32,46	c-fos	neuropeptide Y	314322(Tax:10116)	24604(Tax:10116)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Prolonged induction of c-fos in neuropeptide_Y - and somatostatin-immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation .
10067851	0	c-fos	23,28	parathyroid_hormone	43,62	c-fos	parathyroid hormone	2353	5741	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Increased osteoblastic c-fos expression by parathyroid_hormone requires protein kinase A phosphorylation of the cyclic_adenosine_3 ' ,5 ' - monophosphate response element-binding protein at serine 133 .
10318853	1	c-fos	89,94	parathyroid_hormone	161,180	c-fos	parathyroid hormone	2353	5741	Gene	Gene	proto-oncogene|amod|START_ENTITY induction|nmod|proto-oncogene potentiated|nsubjpass|induction potentiated|nmod|pathway pathway|amod|END_ENTITY	Their weak induction of the c-fos proto-oncogene via Ca2 + mobilization is strongly potentiated by a parathyroid_hormone / cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase .
10366042	0	c-fos	18,23	parathyroid_hormone	40,59	c-fos	parathyroid hormone	14281(Tax:10090)	19226(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY Expression|nmod|gene induced|nsubj|Expression induced|nmod|END_ENTITY	Expression of the c-fos gene induced by parathyroid_hormone in the bones of SAMP6 mice , a murine model for senile_osteoporosis .
7962120	0	c-fos	30,35	parathyroid_hormone	54,73	c-fos	parathyroid hormone	2353	5741	Gene	Gene	induction|amod|START_ENTITY signaling|nmod|induction signaling|nmod|END_ENTITY	Second messenger signaling of c-fos gene induction by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide in osteoblastic_osteosarcoma cells : its role in osteoblast proliferation and osteoclast-like cell formation .
8854242	0	c-fos	75,80	parathyroid_hormone	39,58	c-fos	parathyroid hormone	2353	5741	Gene	Gene	gene|amod|START_ENTITY activate|dobj|gene END_ENTITY|xcomp|activate	Analysis of signaling pathways used by parathyroid_hormone to activate the c-fos gene in human SaOS2 osteoblast-like cells .
9389528	0	c-fos	15,20	parathyroid_hormone	55,74	c-fos	parathyroid hormone	14281(Tax:10090)	19226(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Proto-oncogene c-fos is transcriptionally regulated by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein in a cyclic_adenosine_monophosphate-dependent manner in osteoblastic cells .
8476611	0	c-fos	87,92	prodynorphin	100,112	c-fos	prodynorphin	314322(Tax:10116)	29190(Tax:10116)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Molecular mechanisms of pain : serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons .
7501282	0	c-fos	27,32	proenkephalin_and_tyrosine_hydroxylase	34,72	c-fos	proenkephalin and tyrosine hydroxylase	314322(Tax:10116)	29237;25085	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Differential regulation of c-fos , proenkephalin_and_tyrosine_hydroxylase gene expression by metrazole in the hamster adrenal and hippocampus .
12051724	0	c-fos	23,28	serum_response_factor	107,128	c-fos	serum response factor	2353	6722	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum_response_factor in MCF-7 breast_cancer cells .
1328862	0	c-fos	33,38	serum_response_factor	80,101	c-fos	serum response factor	2353	6722	Gene	Gene	element|amod|START_ENTITY stimulation|nmod|element requires|nsubj|stimulation requires|dobj|END_ENTITY	Maximal serum stimulation of the c-fos serum response element requires both the serum_response_factor and a novel binding factor , SRE-binding protein .
2169025	0	c-fos	14,19	serum_response_factor	61,82	c-fos	serum response factor	2353	6722	Gene	Gene	transcription|amod|START_ENTITY Inhibition|nmod|transcription Inhibition|nmod|END_ENTITY	Inhibition of c-fos transcription and phosphorylation of the serum_response_factor by an inhibitor of phospholipase C-type reactions .
2493627	0	c-fos	39,44	serum_response_factor	45,66	c-fos	serum response factor	2353	6722	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Point mutational analysis of the human c-fos serum_response_factor binding site .
7565750	0	c-fos	66,71	serum_response_factor	35,56	c-fos	serum response factor	14281(Tax:10090)	20807(Tax:10090)	Gene	Gene	element|amod|START_ENTITY facilitates|nmod|element facilitates|dobj|association association|nmod|END_ENTITY	YY1 facilitates the association of serum_response_factor with the c-fos serum response element .
9388250	0	c-fos	100,105	serum_response_factor	51,72	c-fos	serum response factor	2353	6722	Gene	Gene	element|amod|START_ENTITY transactivation|nmod|element END_ENTITY|nmod|transactivation	The CREB-binding_protein -LRB- CBP -RRB- cooperates with the serum_response_factor for transactivation of the c-fos serum response element .
10460009	0	c-fos	14,19	transforming_growth_factor-beta1	59,91	c-fos	transforming growth factor-beta1	314322(Tax:10116)	59086(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Regulation of c-fos gene induction and mitogenic effect of transforming_growth_factor-beta1 in rat articular chondrocyte .
8168613	0	c-fos	13,18	urokinase-type_plasminogen_activator	38,74	c-fos	urokinase-type plasminogen activator	2353	5328	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of c-fos gene expression by urokinase-type_plasminogen_activator in human ovarian_cancer cells .
14607712	0	c-fos	109,114	vascular_endothelial_growth_factor	15,49	c-fos	vascular endothelial growth factor	2353	7422	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|nmod|END_ENTITY	Expressions of vascular_endothelial_growth_factor in cirrhotic tissues and their relations to proto-oncogene c-fos , c-myc .
16627584	0	c-jun	45,50	Gonadotropin-releasing_hormone	0,30	c-jun	Gonadotropin-releasing hormone	3725	2796	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Gonadotropin-releasing_hormone activation of c-jun , but not early_growth_response_factor-1 , stimulates transcription of a luteinizing hormone beta-subunit gene .
1737930	0	c-jun	24,29	IL-3	6,10	c-jun	IL-3	3725	3562	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Human IL-3 induction of c-jun in normal monocytes is independent of tyrosine kinase and involves protein kinase C .
12503187	0	c-jun	29,34	Ki-ras	59,65	c-jun	Ki-ras	3725	3845	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of serum-induced c-jun expression by activated Ki-ras in human colon_cancer cells .
25213759	0	c-jun	18,23	NANOG	0,5	c-jun	NANOG	3725	79923	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	NANOG upregulates c-jun oncogene expression through binding the c-jun promoter .
25213759	0	c-jun	64,69	NANOG	0,5	c-jun	NANOG	3725	79923	Gene	Gene	promoter|amod|START_ENTITY upregulates|nmod|promoter upregulates|nsubj|END_ENTITY	NANOG upregulates c-jun oncogene expression through binding the c-jun promoter .
7796170	0	c-jun	38,43	NR-1	137,141	c-jun	NR-1	3725	2902	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of the immediate early gene c-jun in human spinal cord in amyotrophic_lateral_sclerosis with concomitant loss of NMDA receptor NR-1 and glycine transporter mRNA .
15068801	0	c-jun	45,50	RhoA	30,34	c-jun	RhoA	3725	387	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis .
7943321	0	c-jun	36,41	Tumor_necrosis_factor-alpha	0,27	c-jun	Tumor necrosis factor-alpha	3725	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces c-jun during the regenerative response to liver_injury .
22773970	0	c-jun	47,52	brain-derived_neurotrophic_factor	10,43	c-jun	brain-derived neurotrophic factor	16476(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of brain-derived_neurotrophic_factor on c-jun expression in the rd mouse retina .
15773551	0	c-jun	67,72	c-fos	60,65	c-jun	c-fos	3725	2353	Gene	Gene	Egr-1|amod|START_ENTITY Egr-1|amod|END_ENTITY	-LSB- Effect of anisomycin on activation of early response genes c-fos , c-jun , Egr-1 in cells transformed by E1A and cHa-ras oncogenes -RSB- .
1667087	0	c-jun	23,28	c-fos	47,52	c-jun	c-fos	3725	2353	Gene	Gene	state|amod|START_ENTITY state|amod|END_ENTITY	Selective induction of c-jun and jun-B but not c-fos or c-myc during mitogenesis in SV40-transformed cells at the predifferentiation growth_arrest state .
24022005	0	c-jun	61,66	c-fos	55,60	c-jun	c-fos	3725	2353	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Barriers to transmission of transcriptional noise in a c-fos c-jun pathway .
7673322	0	c-jun	83,88	c-fos	69,74	c-jun	c-fos	16476(Tax:10090)	14281(Tax:10090)	Gene	Gene	cdc2|amod|START_ENTITY cdc2|amod|END_ENTITY	Cells en route to apoptosis are characterized by the upregulation of c-fos , c-myc , c-jun , cdc2 , and RB phosphorylation , resembling events of early cell-cycle traverse .
9737720	0	c-jun	62,67	c-fos	55,60	c-jun	c-fos	3725	2353	Gene	Gene	zif-268|amod|START_ENTITY END_ENTITY|amod|zif-268	Glucose and glucoincretin peptides synergize to induce c-fos , c-jun , junB , zif-268 , and nur-77 gene expression in pancreatic beta -LRB- INS-1 -RRB- cells .
2174893	0	c-jun	14,19	cAMP	39,43	c-jun	cAMP	3725	820	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of c-jun gene expression by cAMP in HL-60 myeloid_leukemia cells .
16627584	0	c-jun	45,50	early_growth_response_factor-1	60,90	c-jun	early growth response factor-1	3725	1958	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Gonadotropin-releasing_hormone activation of c-jun , but not early_growth_response_factor-1 , stimulates transcription of a luteinizing hormone beta-subunit gene .
12953797	0	c-jun	92,97	extracellular_signal-regulated_kinase	123,160	c-jun	extracellular signal-regulated kinase	16476(Tax:10090)	26413(Tax:10090)	Gene	Gene	expressions|amod|START_ENTITY expressions|nmod|END_ENTITY	Suppressive effect of taurine on platelet-derived growth factor -LRB- PDGF -RRB- BB-induced c-fos and c-jun mRNA expressions through extracellular_signal-regulated_kinase -LRB- ERK -RRB- in mesenchymal cell lines .
8793856	0	c-jun	21,26	gonadotropin-releasing_hormone	100,130	c-jun	gonadotropin-releasing hormone	3725	2796	Gene	Gene	cloning|nmod|START_ENTITY cDNAs|nsubj|cloning cDNAs|nmod|stimulation stimulation|amod|END_ENTITY	Molecular cloning of c-jun and c-fos cDNAs from porcine anterior pituitary and their involvement in gonadotropin-releasing_hormone stimulation .
10477563	0	c-jun	63,68	gp34	103,107	c-jun	gp34	3725	7292	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Intracellular signaling of gp34 , the OX40 ligand : induction of c-jun and c-fos mRNA expression through gp34 upon binding of its receptor , OX40 .
10327051	0	c-jun	97,102	p300	115,119	c-jun	p300	3725	2033	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A .
15857712	0	c-jun	89,94	p75_neurotrophin_receptor	23,48	c-jun	p75 neurotrophin receptor	16476(Tax:10090)	18053(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Differential effect of p75_neurotrophin_receptor on expression of pro-apoptotic proteins c-jun , p38 and caspase-3 in dorsal root ganglion cells after axotomy in experimental diabetes .
9361192	0	c-jun	24,29	retinoic_acid_receptor_beta	39,66	c-jun	retinoic acid receptor beta	3725	5915	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Increased expression of c-jun , but not retinoic_acid_receptor_beta , is associated with F9_teratocarcinoma stem cell differentiation induced by polyamine depletion .
19947601	0	c-jun-N-terminal_kinase	91,114	JNK	116,119	c-jun-N-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis , biological evaluation , X-ray structure , and pharmacokinetics of aminopyrimidine c-jun-N-terminal_kinase -LRB- JNK -RRB- inhibitors .
12931215	0	c-jun-terminal_kinase	24,45	JNK	47,50	c-jun-terminal kinase	JNK	5599	5599	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Sustained activation of c-jun-terminal_kinase -LRB- JNK -RRB- is closely related to arsenic_trioxide-induced apoptosis in an acute_myeloid_leukemia -LRB- M2 -RRB- - derived cell line , NKM-1 .
10901161	0	c-jun_N-terminal_kinase	14,37	4-1BB	41,46	c-jun N-terminal kinase	4-1BB	5599	3604	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-jun_N-terminal_kinase by 4-1BB -LRB- CD137 -RRB- , a T cell co-stimulatory molecule .
12871843	0	c-jun_N-terminal_kinase	8,31	GM-CSF	58,64	c-jun N-terminal kinase	GM-CSF	5599	1437	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Role of c-jun_N-terminal_kinase in the induced release of GM-CSF , RANTES and IL-8 from human airway smooth muscle cells .
11971973	0	c-jun_N-terminal_kinase	24,47	Hsp72	0,5	c-jun N-terminal kinase	Hsp72	5599	3303	Gene	Gene	regulate|advmod|START_ENTITY regulate|nsubj|END_ENTITY	Hsp72 and stress kinase c-jun_N-terminal_kinase regulate the bid-dependent pathway in tumor_necrosis_factor-induced apoptosis .
10381634	0	c-jun_N-terminal_kinase	32,55	JNK	57,60	c-jun N-terminal kinase	JNK	116554(Tax:10116)	116554(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Etoposide-induced activation of c-jun_N-terminal_kinase -LRB- JNK -RRB- correlates with drug-induced apoptosis in salivary gland acinar cells .
24332487	0	c-jun_N-terminal_kinase	48,71	JNK	73,76	c-jun N-terminal kinase	JNK	5599	5599	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and SAR of novel isoxazoles as potent c-jun_N-terminal_kinase -LRB- JNK -RRB- inhibitors .
11043575	0	c-jun_N-terminal_kinase	35,58	Prolactin	0,9	c-jun N-terminal kinase	Prolactin	116554(Tax:10116)	24683(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Prolactin stimulates activation of c-jun_N-terminal_kinase -LRB- JNK -RRB- .
17027916	0	c-jun_N-terminal_kinase	116,139	RANTES	42,48	c-jun N-terminal kinase	RANTES	5599	6352	Gene	Gene	pathway|amod|START_ENTITY inhibition|nmod|pathway secretion|nmod|inhibition END_ENTITY|acl|secretion	Isoproterenol suppresses cytokine-induced RANTES secretion in human lung epithelial cells through the inhibition of c-jun_N-terminal_kinase pathway .
22166618	0	c-jun_N-terminal_kinase_2	119,144	JNK2	146,150	c-jun N-terminal kinase 2	JNK2	26420(Tax:10090)	26420(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- pathway .
11596105	0	c-kit	75,80	AP-2_transcription_factor	14,39	c-kit	AP-2 transcription factor	3815	7020	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Expression of AP-2_transcription_factor and of its downstream target genes c-kit , E-cadherin and p21 in human cutaneous_melanoma .
16034306	0	c-kit	37,42	CD-117	44,50	c-kit	CD-117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	An immunohistochemical evaluation of c-kit -LRB- CD-117 -RRB- expression in malignant_melanoma , and results of imatinib_mesylate -LRB- Gleevec -RRB- therapy in three patients .
11151069	0	c-kit	14,19	CD117	21,26	c-kit	CD117	3815	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of c-kit -LRB- CD117 -RRB- in benign and malignant human endometrial epithelium .
12613538	0	c-kit	74,79	CD117	67,72	c-kit	CD117	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical identification of HER-2 / neu overexpression and CD117 -LRB- c-kit -RRB- expression in multiple myeloma .
15105813	0	c-kit	8,13	CD117	15,20	c-kit	CD117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lack of c-kit -LRB- CD117 -RRB- expression in CD30 + lymphomas and lymphomatoid_papulosis .
16056250	0	c-kit	21,26	CD117	14,19	c-kit	CD117	3815	3815	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Expression of CD117 -LRB- c-kit -RRB- receptor in dysgerminoma_of_the_ovary : diagnostic and therapeutic implications .
16441409	0	c-kit	14,19	CD117	21,26	c-kit	CD117	3815	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of c-kit -LRB- CD117 -RRB- in Spitz_nevus and malignant_melanoma .
18568298	0	c-kit	20,25	CD117	27,32	c-kit	CD117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Characterization of c-kit -LRB- CD117 -RRB- expression in human normal pituitary cells and pituitary_adenomas .
20177846	0	c-kit	0,5	CD117	7,12	c-kit	CD117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	c-kit -LRB- CD117 -RRB- expression in human tumors and its prognostic value : an immunohistochemical analysis .
24577437	0	c-kit	7,12	CD117	0,5	c-kit	CD117	3815	3815	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
25643775	0	c-kit	42,47	CD117	35,40	c-kit	CD117	3815	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Immunohistochemical Expression of CD117 -LRB- c-kit -RRB- in 75 Renal Cell Tumors -RSB- .
1378163	0	c-kit	0,5	CD13	132,136	c-kit	CD13	3815	290	Gene	Gene	expression|amod|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|nmod|END_ENTITY	c-kit gene expression in CD7-positive acute_lymphoblastic_leukemia : close correlation with expression of myeloid-associated antigen CD13 .
22558265	0	c-kit	50,55	CD133	43,48	c-kit	CD133	16590(Tax:10090)	19126(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|dobj|cells	Overexpression of angiopoietin-1 increases CD133 + / c-kit + cells and reduces myocardial apoptosis in db/db mouse infarcted hearts .
15105813	0	c-kit	8,13	CD30	36,40	c-kit	CD30	3815	943	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Lack of c-kit -LRB- CD117 -RRB- expression in CD30 + lymphomas and lymphomatoid_papulosis .
9305612	0	c-kit	10,15	CD30	22,26	c-kit	CD30	3815	943	Gene	Gene	high|amod|START_ENTITY JURL-MK1|dep|high JURL-MK1|dep|END_ENTITY	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
9305612	0	c-kit	49,54	CD30	60,64	c-kit	CD30	3815	943	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
10634171	0	c-kit	118,123	CD34	91,95	c-kit	CD34	16590(Tax:10090)	12490(Tax:10090)	Gene	Gene	+|amod|START_ENTITY END_ENTITY|dep|+	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
11177593	0	c-kit	29,34	CD34	64,68	c-kit	CD34	3815	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Co-transduction of cDNAs for c-kit and steel_factor into single CD34 + cord blood cells further enhances the growth of erythroid and multipotential progenitors .
14667198	0	c-kit	15,20	CD34	96,100	c-kit	CD34	3815	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|transforming_growth_factor-beta transforming_growth_factor-beta|nmod|CD38 CD38|compound|END_ENTITY	Correlation of c-kit expression and cell cycle regulation by transforming_growth_factor-beta in CD34 + CD38 - human bone marrow cells .
1720696	0	c-kit	0,5	CD34	20,24	c-kit	CD34	3815	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	c-kit expression by CD34 + bone marrow progenitors and inhibition of response to recombinant human interleukin-3 following exposure to c-kit antisense oligonucleotides .
1720696	0	c-kit	134,139	CD34	20,24	c-kit	CD34	3815	947	Gene	Gene	oligonucleotides|amod|START_ENTITY +|nmod|oligonucleotides +|nsubj|expression expression|nmod|END_ENTITY	c-kit expression by CD34 + bone marrow progenitors and inhibition of response to recombinant human interleukin-3 following exposure to c-kit antisense oligonucleotides .
19421145	0	c-kit	25,30	CD34	45,49	c-kit	CD34	3815	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	PLZF-mediated control on c-kit expression in CD34 -LRB- + -RRB- cells and early erythropoiesis .
23104253	0	c-kit	58,63	CD34	53,57	c-kit	CD34	3815	947	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Mesenchymal stem cells promote a primitive phenotype CD34 + c-kit + in human cord blood-derived hematopoietic stem cells during ex vivo expansion .
24577437	0	c-kit	7,12	CD34	28,32	c-kit	CD34	3815	947	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|+ +|compound|END_ENTITY	CD117 -LRB- c-kit -RRB- expression on CD34 + cells participates in the cytogenetic response to imatinib in patients with chronic_myeloid_leukemia in the first chronic phase .
7522108	0	c-kit	37,42	CD34	46,50	c-kit	CD34	3815	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Expression of adhesion molecules and c-kit on CD34 + hematopoietic progenitor cells : comparison of cytokine-mobilized blood stem cells with normal bone marrow and peripheral blood .
7522632	0	c-kit	54,59	CD34	131,135	c-kit	CD34	3815	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
8701944	0	c-kit	20,25	CD34	14,18	c-kit	CD34	3815	947	Gene	Gene	+|amod|START_ENTITY +|nummod|+ +|compound|END_ENTITY	Deficiency of CD34 + c-kit + and CD34 +38 - hematopoietic precursors in aplastic_anemia after immunosuppressive treatment .
9074422	0	c-kit	146,151	CD34	140,144	c-kit	CD34	3815	947	Gene	Gene	cells|compound|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	Action of human interleukin-4 and stem_cell_factor on erythroid and mixed colony formation by peripheral blood-derived CD34 + c-kit -LRB- high -RRB- or CD34 + c-kit -LRB- low -RRB- cells .
9186537	0	c-kit	149,154	CD34	94,98	c-kit	CD34	3815	947	Gene	Gene	protein|amod|START_ENTITY levels|nmod|protein expressing|dobj|levels expressing|nsubj|progenitors progenitors|compound|END_ENTITY	Human FLT3_ligand acts on myeloid as well as multipotential progenitors derived from purified CD34 + blood progenitors expressing different levels of c-kit protein .
9402654	0	c-kit	13,18	CD34	38,42	c-kit	CD34	3815	947	Gene	Gene	molecules|amod|START_ENTITY Induction|nmod|molecules Induction|nmod|+ +|compound|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	c-kit	13,18	CD34	76,80	c-kit	CD34	3815	947	Gene	Gene	molecules|amod|START_ENTITY Induction|nmod|molecules Induction|parataxis|cells cells|dep|evidence evidence|nmod|+ +|compound|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	c-kit	44,49	CD34	38,42	c-kit	CD34	3815	947	Gene	Gene	cells|amod|START_ENTITY Induction|parataxis|cells Induction|nmod|+ +|compound|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	c-kit	44,49	CD34	76,80	c-kit	CD34	3815	947	Gene	Gene	cells|amod|START_ENTITY cells|dep|evidence evidence|nmod|+ +|compound|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	c-kit	82,87	CD34	38,42	c-kit	CD34	3815	947	Gene	Gene	cells|amod|START_ENTITY cells|dep|cells Induction|parataxis|cells Induction|nmod|+ +|compound|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9402654	0	c-kit	82,87	CD34	76,80	c-kit	CD34	3815	947	Gene	Gene	cells|amod|START_ENTITY cells|dep|cells cells|dep|evidence evidence|nmod|+ +|compound|END_ENTITY	Induction of c-kit molecules on human CD34 + / c-kit < low cells : evidence for CD34 + / c-kit < low cells as primitive hematopoietic stem cells .
9305612	0	c-kit	10,15	CD40	28,32	c-kit	CD40	3815	958	Gene	Gene	high|amod|START_ENTITY JURL-MK1|dep|high JURL-MK1|dep|CD30 CD30|dep|END_ENTITY	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
9305612	0	c-kit	49,54	CD40	66,70	c-kit	CD40	3815	958	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	JURL-MK1 -LRB- c-kit -LRB- high -RRB- / CD30 - / CD40 - -RRB- and JURL-MK2 -LRB- c-kit -LRB- low -RRB- / CD30 + / CD40 + -RRB- cell lines : ` two-sided ' model for investigating leukemic megakaryocytopoiesis .
18252864	0	c-kit	54,59	CD41	49,53	c-kit	CD41	16590(Tax:10090)	16399(Tax:10090)	Gene	Gene	progenitors|amod|START_ENTITY progenitors|compound|END_ENTITY	Modulation of murine embryonic stem cell-derived CD41 + c-kit + hematopoietic progenitors by ectopic expression of Cdx genes .
26416056	0	c-kit	14,19	CD_117	21,27	c-kit	CD 117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Evaluation of c-kit -LRB- CD_117 -RRB- expression as a prognostic factor in testicular_germ_cell_tumors : an Izmir Oncology Group -LRB- IZOG -RRB- study .
18941208	0	c-kit	8,13	CX3CR1	0,6	c-kit	CX3CR1	3815	1524	Gene	Gene	cells|amod|START_ENTITY cells|nummod|+ +|compound|END_ENTITY	CX3CR1 + c-kit + bone marrow cells give rise to CD103 + and CD103 - dendritic cells with distinct functional properties .
23548624	0	c-kit	6,11	FIH-1	0,5	c-kit	FIH-1	16590(Tax:10090)	319594(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|appos|signaling	FIH-1 / c-kit signaling : a novel contributor to corneal epithelial glycogen metabolism .
24593859	0	c-kit	52,57	FLK-1	65,70	c-kit	FLK-1	3815	3791	Gene	Gene	Cells|dep|START_ENTITY Cells|dep|END_ENTITY	Embryonic Stem Cells and Released Factors Stimulate c-kit -LRB- + ve -RRB- / FLK-1 -LRB- + ve -RRB- Progenitor Cells and Promote Neovascularization in Doxorubicin-induced Cardiomyopathy .
16570574	0	c-kit	14,19	Flk-1	21,26	c-kit	Flk-1	3815	3791	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Expression of c-kit , Flk-1 , and Flk-2 receptors in benign and malignant_tumors of follicular epithelial origin .
17850794	0	c-kit	47,52	Flk-1	14,19	c-kit	Flk-1	3815	3791	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression plays|dobj|role plays|nsubj|END_ENTITY	VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells .
11672547	0	c-kit	68,73	Flt3	16,20	c-kit	Flt3	16590(Tax:10090)	14255(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Upregulation of Flt3 expression within the bone marrow Lin -LRB- - -RRB- Sca1 -LRB- + -RRB- c-kit -LRB- + -RRB- stem cell compartment is accompanied by loss of self-renewal capacity .
1721642	0	c-kit	15,20	IL-4	0,4	c-kit	IL-4	3815	3565	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-4 regulates c-kit proto-oncogene product expression in human mast and myeloid progenitor cells .
7543134	0	c-kit	22,27	IL-7R	28,33	c-kit	IL-7R	3815	3575	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Cell cycle control of c-kit + IL-7R + B precursor cells by two distinct signals derived from IL-7 receptor and c-kit in a fully defined medium .
8879216	0	c-kit	87,92	IL-7R	94,99	c-kit	IL-7R	16590(Tax:10090)	16197(Tax:10090)	Gene	Gene	progenitors|amod|START_ENTITY progenitors|compound|END_ENTITY	Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit + IL-7R + Thy1 + lympho-hemopoietic progenitors develop .
8519688	0	c-kit	43,48	Interleukin_4	0,13	c-kit	Interleukin 4	3815	3565	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin_4 down-regulates expression of c-kit and autocrine stem_cell_factor in human colorectal_carcinoma cells .
17298867	0	c-kit	47,52	KIT	22,25	c-kit	KIT	3815	3815	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing_sarcomas .
21399664	0	c-kit	24,29	MicroRNA-193a	0,13	c-kit	MicroRNA-193a	3815	406968	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute_myeloid_leukemia .
22349512	0	c-kit	17,22	Rab27b	0,6	c-kit	Rab27b	3815	5874	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rab27b regulates c-kit expression by controlling the secretion of stem_cell_factor .
11222388	0	c-kit	89,94	SCF	75,78	c-kit	SCF	3815	4254	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor -LRB- c-kit -RRB- in a human myeloid_leukemia cell line and in acute myeloid_leukemia blasts .
17214848	0	c-kit	89,94	SCF	55,58	c-kit	SCF	3815	4254	Gene	Gene	FGFR-1|dep|START_ENTITY factors|appos|FGFR-1 factors|appos|bFGF bFGF|dep|END_ENTITY	Protein expression of melanocyte growth factors -LRB- bFGF , SCF -RRB- and their receptors -LRB- FGFR-1 , c-kit -RRB- in nevi and melanoma .
18006465	0	c-kit	95,100	SCF	37,40	c-kit	SCF	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	bone|amod|START_ENTITY delivered|iobj|bone improves|ccomp|delivered improves|nsubj|injection injection|appos|END_ENTITY	Local injection of stem_cell_factor -LRB- SCF -RRB- improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells .
20850173	0	c-kit	16,21	SCF	44,47	c-kit	SCF	3815	4254	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of c-kit and stem_cell_factor -LRB- SCF -RRB- in ovarian follicular epithelium of a lizard , Podarcis s. sicula .
26428235	0	c-kit	10,15	SCF	90,93	c-kit	SCF	3815	4254	Gene	Gene	receptor|amod|START_ENTITY Targeting|dobj|receptor Targeting|nmod|neuroblastomas neuroblastomas|acl|using using|dobj|stem_cell_factor stem_cell_factor|appos|END_ENTITY	Targeting c-kit receptor in neuroblastomas and colorectal_cancers using stem_cell_factor -LRB- SCF -RRB- - based recombinant bacterial toxins .
7529338	0	c-kit	18,23	SCF	72,75	c-kit	SCF	3815	4254	Gene	Gene	proto-oncogene|amod|START_ENTITY Expression|nmod|proto-oncogene Expression|appos|END_ENTITY	Expression of the c-kit proto-oncogene and its ligand stem_cell_factor -LRB- SCF -RRB- in normal and malignant human testicular tissue .
8691142	0	c-kit	35,40	SCF	29,32	c-kit	SCF	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY role|dep|interaction role|nmod|stem_cell_factor stem_cell_factor|appos|END_ENTITY	A role for stem_cell_factor -LRB- SCF -RRB- : c-kit interaction -LRB- s -RRB- in the intestinal tract response to Salmonella_typhimurium infection .
8698135	0	c-kit	62,67	SCF	23,26	c-kit	SCF	3815	4254	Gene	Gene	expression|amod|START_ENTITY use|nmod|expression use|nmod|protein protein|compound|END_ENTITY	The use of recombinant SCF protein for rapid determination of c-kit expression in normal and abnormal erythropoiesis .
9508539	0	c-kit	28,33	SCF	67,70	c-kit	SCF	3815	4254	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of protooncogene c-kit and its ligand stem_cell_factor -LRB- SCF -RRB- in gastric_carcinoma cell lines .
9858422	0	c-kit	55,60	SCF	32,35	c-kit	SCF	3815	4254	Gene	Gene	stem_cell_factor|appos|START_ENTITY stem_cell_factor|appos|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- and SCF receptor -LRB- c-kit -RRB- in synovial membrane in arthritis : correlation with synovial mast_cell_hyperplasia and inflammation .
10634171	0	c-kit	118,123	Sca-1	98,103	c-kit	Sca-1	16590(Tax:10090)	110454(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|dep|+ +|compound|END_ENTITY	Hematopoietic reconstitution of syngeneic mice with a peripheral blood-derived , monoclonal CD34 - , Sca-1 + , Thy-1 -LRB- low -RRB- , c-kit + stem cell line .
23273785	0	c-kit	35,40	Sca-1	42,47	c-kit	Sca-1	16590(Tax:10090)	110454(Tax:10090)	Gene	Gene	CXCR4|amod|START_ENTITY CXCR4|compound|END_ENTITY	Distribution and homing pattern of c-kit + Sca-1 + CXCR4 + resident cardiac stem cells in neonatal , postnatal , and adult mouse heart .
11672547	0	c-kit	68,73	Sca1	61,65	c-kit	Sca1	16590(Tax:10090)	12367(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of Flt3 expression within the bone marrow Lin -LRB- - -RRB- Sca1 -LRB- + -RRB- c-kit -LRB- + -RRB- stem cell compartment is accompanied by loss of self-renewal capacity .
10582791	0	c-kit	17,22	Stem_cell_factor	0,16	c-kit	Stem cell factor	3815	4254	Gene	Gene	system|amod|START_ENTITY END_ENTITY|dep|system	Stem_cell_factor / c-kit system in spermatogenesis .
10849422	0	c-kit	17,22	Stem_cell_factor	0,16	c-kit	Stem cell factor	3815	4254	Gene	Gene	up-regulates|amod|START_ENTITY cyclin_D3|nsubj|up-regulates END_ENTITY|parataxis|cyclin_D3	Stem_cell_factor / c-kit up-regulates cyclin_D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 _ S6_kinase pathway in spermatogonia .
11438205	0	c-kit	26,31	Stem_cell_factor	0,16	c-kit	Stem cell factor	3815	4254	Gene	Gene	cells|amod|START_ENTITY protects|dobj|cells protects|nsubj|END_ENTITY	Stem_cell_factor protects c-kit + human primary erythroid cells from apoptosis .
1381568	0	c-kit	18,23	Stem_cell_factor	1,17	c-kit	Stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY -RSB-|nsubj|interaction END_ENTITY|parataxis|-RSB-	-LSB- Stem_cell_factor / c-kit interaction in primordial germ cell , melanoblast and hematopoietic progenitors -RSB- .
14985355	0	c-kit	17,22	Stem_cell_factor	0,16	c-kit	Stem cell factor	3815	4254	Gene	Gene	signaling|amod|START_ENTITY promotes|nsubj|signaling END_ENTITY|parataxis|promotes	Stem_cell_factor / c-kit signaling promotes the survival , migration , and capillary tube formation of human umbilical vein endothelial cells .
17410437	0	c-kit	17,22	Stem_cell_factor	0,16	c-kit	Stem cell factor	3815	4254	Gene	Gene	signaling|amod|START_ENTITY enhances|nsubj|signaling END_ENTITY|parataxis|enhances	Stem_cell_factor / c-kit receptor signaling enhances the proliferation and invasion of colorectal_cancer cells through the PI3K/Akt pathway .
8527164	0	c-kit	84,89	Stem_cell_factor	0,16	c-kit	Stem cell factor	3815	4254	Gene	Gene	associates|nmod|START_ENTITY phosphorylation|acl:relcl|associates induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Stem_cell_factor induces phosphorylation of a 200 kDa protein which associates with c-kit .
8879216	0	c-kit	87,92	Thy1	101,105	c-kit	Thy1	16590(Tax:10090)	21838(Tax:10090)	Gene	Gene	progenitors|amod|START_ENTITY progenitors|compound|END_ENTITY	Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit + IL-7R + Thy1 + lympho-hemopoietic progenitors develop .
7522632	0	c-kit	54,59	Tumor_necrosis_factor_alpha	0,27	c-kit	Tumor necrosis factor alpha	3815	7124	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
11573203	0	c-kit	79,84	VCAM-1	89,95	c-kit	VCAM-1	16590(Tax:10090)	22329(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Detection of murine adult bone marrow stroma-initiating cells in Lin -LRB- - -RRB- c-fms -LRB- + -RRB- c-kit -LRB- low -RRB- VCAM-1 -LRB- + -RRB- cells .
9221761	0	c-kit	56,61	VCAM-1	213,219	c-kit	VCAM-1	3815	7412	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|stem_cell_factor stem_cell_factor|appos|END_ENTITY	Human peripheral blood eosinophils express a functional c-kit receptor for stem_cell_factor that stimulates very late antigen 4 -LRB- VLA-4 -RRB- - mediated cell adhesion to fibronectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- .
11573203	0	c-kit	79,84	c-fms	71,76	c-kit	c-fms	16590(Tax:10090)	12978(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Detection of murine adult bone marrow stroma-initiating cells in Lin -LRB- - -RRB- c-fms -LRB- + -RRB- c-kit -LRB- low -RRB- VCAM-1 -LRB- + -RRB- cells .
9345035	0	c-kit	93,98	c-fms	79,84	c-kit	c-fms	3815	1436	Gene	Gene	dependent|amod|START_ENTITY END_ENTITY|dep|dependent	Development of osteoclasts from embryonic_stem cells through a pathway that is c-fms but not c-kit dependent .
10849422	0	c-kit	17,22	cyclin_D3	36,45	c-kit	cyclin D3	3815	896	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Stem_cell_factor / c-kit up-regulates cyclin_D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 _ S6_kinase pathway in spermatogonia .
9108382	0	c-kit	52,57	interleukin-6	34,47	c-kit	interleukin-6	16590(Tax:10090)	16193(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Differential release of mast cell interleukin-6 via c-kit .
7514200	0	c-kit	61,66	mast_cell_growth_factor	27,50	c-kit	mast cell growth factor	16590(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|receptor receptor|compound|END_ENTITY	Differential expression of mast_cell_growth_factor receptor -LRB- c-kit -RRB- by peritoneal connective tissue-type mast cells and tissue culture-derived mast cells .
10792276	0	c-kit	29,34	stem_cell_factor	102,118	c-kit	stem cell factor	3815	4254	Gene	Gene	mutation|amod|START_ENTITY bearing|dobj|mutation cells|acl|bearing characterized|nsubjpass|cells characterized|nmod|END_ENTITY	Mastocytosis cells bearing a c-kit activating point mutation are characterized by hypersensitivity to stem_cell_factor and increased apoptosis .
11286626	0	c-kit	39,44	stem_cell_factor	22,38	c-kit	stem cell factor	3815	4254	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	The paracrine role of stem_cell_factor / c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation .
12199785	0	c-kit	52,57	stem_cell_factor	185,201	c-kit	stem cell factor	3815	4254	Gene	Gene	receptors|amod|START_ENTITY express|dobj|receptors express|nmod|END_ENTITY	Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin 's _ disease-involved lymph nodes through soluble and membrane-bound stem_cell_factor .
12322893	0	c-kit	57,62	stem_cell_factor	40,56	c-kit	stem cell factor	3815	4254	Gene	Gene	system|amod|START_ENTITY END_ENTITY|dep|system	Molecular genetics of male_infertility : stem_cell_factor / c-kit system .
1280476	0	c-kit	15,20	stem_cell_factor	22,38	c-kit	stem cell factor	3815	4254	Gene	Gene	ligand|nmod|START_ENTITY ligand|appos|END_ENTITY	The ligand for c-kit , stem_cell_factor , stimulates the circulation of cells that engraft lethally irradiated baboons .
1375244	0	c-kit	105,110	stem_cell_factor	70,86	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY ligand|nmod|receptor END_ENTITY|appos|ligand	Stimulation of mouse connective tissue-type mast cells by hemopoietic stem_cell_factor , a ligand for the c-kit receptor .
1375870	0	c-kit	98,103	stem_cell_factor	18,34	c-kit	stem cell factor	3815	4254	Gene	Gene	protooncogene|amod|START_ENTITY expressing|dobj|protooncogene line|acl|expressing growth|nmod|line stimulates|dobj|growth stimulates|nsubj|END_ENTITY	Recombinant human stem_cell_factor stimulates growth of a human glioblastoma cell line expressing c-kit protooncogene .
1378316	0	c-kit	71,76	stem_cell_factor	42,58	c-kit	stem cell factor	3815	4254	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Nonhematopoietic_tumor cell lines express stem_cell_factor and display c-kit receptors .
14666642	0	c-kit	43,48	stem_cell_factor	14,30	c-kit	stem cell factor	3815	4254	Gene	Gene	expression|amod|START_ENTITY Expression|nmod|expression Expression|nmod|END_ENTITY	Expression of stem_cell_factor and lack of c-kit expression in malignant_fibrous_histiocytoma of soft tissues .
17026507	0	c-kit	49,54	stem_cell_factor	14,30	c-kit	stem cell factor	3815	4254	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of stem_cell_factor and its receptor , c-kit , in human oral mesenchymal cells .
17044945	0	c-kit	21,26	stem_cell_factor	4,20	c-kit	stem cell factor	3815	4254	Gene	Gene	receptor|amod|START_ENTITY enhances|nsubj|receptor END_ENTITY|parataxis|enhances	The stem_cell_factor / c-kit receptor pathway enhances proliferation and invasion of pancreatic_cancer cells .
1714329	0	c-kit	73,78	stem_cell_factor	44,60	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY effects|dep|ligand effects|nmod|hematopoiesis hematopoiesis|nmod|END_ENTITY	The effects on hematopoiesis of recombinant stem_cell_factor -LRB- ligand for c-kit -RRB- administered in vivo to mice either alone or in combination with granulocyte_colony-stimulating_factor .
1715219	0	c-kit	109,114	stem_cell_factor	80,96	c-kit	stem cell factor	16590(Tax:10090)	60427(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|Enhancement Enhancement|nmod|formation formation|nmod|culture culture|nmod|END_ENTITY	Enhancement of murine blast cell colony formation in culture by recombinant rat stem_cell_factor , ligand for c-kit .
18006465	0	c-kit	95,100	stem_cell_factor	19,35	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	bone|amod|START_ENTITY delivered|iobj|bone improves|ccomp|delivered improves|nsubj|injection injection|nmod|END_ENTITY	Local injection of stem_cell_factor -LRB- SCF -RRB- improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells .
18423881	0	c-kit	65,70	stem_cell_factor	15,31	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of stem_cell_factor and its receptor tyrosine kinase c-kit in pain regulation .
19675587	0	c-kit	38,43	stem_cell_factor	21,37	c-kit	stem cell factor	3815	4254	Gene	Gene	expression|amod|START_ENTITY Relationship|dep|expression Relationship|nmod|END_ENTITY	Relationship between stem_cell_factor / c-kit expression in peripheral blood and blood pressure .
20377480	0	c-kit	94,99	stem_cell_factor	10,26	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	blockade|nmod|START_ENTITY improves|nmod|blockade improves|nsubj|END_ENTITY	Exogenous stem_cell_factor improves interstitial cells of Cajal restoration after blockade of c-kit signaling pathway .
20596251	0	c-kit	31,36	stem_cell_factor	14,30	c-kit	stem cell factor	3815	4254	Gene	Gene	signaling|nsubj|START_ENTITY Expression|parataxis|signaling Expression|nmod|END_ENTITY	Expression of stem_cell_factor / c-kit signaling pathway components in diabetic_fibrovascular_epiretinal_membranes .
22349512	0	c-kit	17,22	stem_cell_factor	66,82	c-kit	stem cell factor	3815	4254	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|advcl|controlling controlling|dobj|secretion secretion|nmod|END_ENTITY	Rab27b regulates c-kit expression by controlling the secretion of stem_cell_factor .
22562362	0	c-kit	94,99	stem_cell_factor	77,93	c-kit	stem cell factor	3815	4254	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Endothelial cell-fatty_acid_binding_protein_4 promotes angiogenesis : role of stem_cell_factor / c-kit pathway .
26428235	0	c-kit	10,15	stem_cell_factor	72,88	c-kit	stem cell factor	3815	4254	Gene	Gene	receptor|amod|START_ENTITY Targeting|dobj|receptor Targeting|nmod|neuroblastomas neuroblastomas|acl|using using|dobj|END_ENTITY	Targeting c-kit receptor in neuroblastomas and colorectal_cancers using stem_cell_factor -LRB- SCF -RRB- - based recombinant bacterial toxins .
26705118	0	c-kit	31,36	stem_cell_factor	14,30	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	attenuates|amod|START_ENTITY neonatal|nsubj|attenuates Antagonism|parataxis|neonatal Antagonism|nmod|END_ENTITY	Antagonism of stem_cell_factor / c-kit signaling attenuates neonatal chronic hypoxia-induced pulmonary_vascular remodeling .
7506674	0	c-kit	89,94	stem_cell_factor	43,59	c-kit	stem cell factor	3815	4254	Gene	Gene	gene|amod|START_ENTITY expressing|dobj|gene Inhibition|acl|expressing Inhibition|nmod|differentiation differentiation|nmod|END_ENTITY	Inhibition of erythroid differentiation by stem_cell_factor in K562 cells expressing the c-kit gene .
7514454	0	c-kit	60,65	stem_cell_factor	33,49	c-kit	stem cell factor	3815	4254	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|density density|nmod|receptor receptor|compound|END_ENTITY	Regulation of the density of the stem_cell_factor receptor -LRB- c-kit -RRB- by tumor_necrosis_factor_alpha on a human myeloid cell line .
7527665	0	c-kit	178,183	stem_cell_factor	23,39	c-kit	stem cell factor	3815	4254	Gene	Gene	protein|amod|START_ENTITY levels|nmod|protein expressing|dobj|levels progenitors|acl|expressing +|dobj|progenitors +|nsubj|actions actions|nmod|END_ENTITY	Synergistic actions of stem_cell_factor and other burst-promoting activities on proliferation of CD34 + highly purified blood progenitors expressing HLA-DR or different levels of c-kit protein .
7527782	0	c-kit	0,5	stem_cell_factor	15,31	c-kit	stem cell factor	3815	4254	Gene	Gene	protein|amod|START_ENTITY protein|appos|receptor receptor|compound|END_ENTITY	c-kit protein -LRB- stem_cell_factor receptor -RRB- expression on cells with erythroid characteristics and on normal human bone marrow without the use of monoclonal antibodies .
7543307	0	c-kit	11,16	stem_cell_factor	63,79	c-kit	stem cell factor	3815	4254	Gene	Gene	receptor|amod|START_ENTITY Absence|nmod|receptor proliferative|nsubj|Absence proliferative|advcl|END_ENTITY	Absence of c-kit receptor and absent proliferative response to stem_cell_factor in childhood Burkitt 's lymphoma cells .
7680037	0	c-kit	8,13	stem_cell_factor	94,110	c-kit	stem cell factor	3815	4254	Gene	Gene	proteins|amod|START_ENTITY confine|nsubj|proteins confine|dobj|site site|nmod|END_ENTITY	Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem_cell_factor .
7680956	0	c-kit	118,123	stem_cell_factor	18,34	c-kit	stem cell factor	3815	4254	Gene	Gene	protooncogene|amod|START_ENTITY expressing|dobj|protooncogene lines|acl|expressing chemotaxis|nmod|lines mediates|dobj|chemotaxis mediates|nsubj|END_ENTITY	Recombinant human stem_cell_factor mediates chemotaxis of small-cell_lung_cancer cell lines aberrantly expressing the c-kit protooncogene .
7682764	0	c-kit	4,9	stem_cell_factor	20,36	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The c-kit receptor , stem_cell_factor , and mast cells .
7687925	0	c-kit	179,184	stem_cell_factor	89,105	c-kit	stem cell factor	3815	4254	Gene	Gene	product|amod|START_ENTITY down-regulation|nmod|product interferes|nmod|down-regulation interferes|nmod|activity activity|nmod|END_ENTITY	Transforming_growth_factor-beta_1 interferes with the proliferation-inducing activity of stem_cell_factor in myelogenous_leukemia blasts through functional down-regulation of the c-kit proto-oncogene product .
8519688	0	c-kit	43,48	stem_cell_factor	63,79	c-kit	stem cell factor	3815	4254	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Interleukin_4 down-regulates expression of c-kit and autocrine stem_cell_factor in human colorectal_carcinoma cells .
8605335	0	c-kit	85,90	stem_cell_factor	31,47	c-kit	stem cell factor	16590(Tax:10090)	4254	Gene	Gene	mutations|amod|START_ENTITY mimics|dobj|mutations mimics|nsubj|expression expression|nmod|END_ENTITY	Xenogeneic expression of human stem_cell_factor in transgenic_mice mimics codominant c-kit mutations .
8605337	0	c-kit	154,159	stem_cell_factor	137,153	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY interaction|compound|END_ENTITY	A novel hematopoietic multilineage clone , Myl-D-7 , is stromal cell-dependent and supported by an alternative mechanism -LRB- s -RRB- independent of stem_cell_factor / c-kit interaction .
8691142	0	c-kit	35,40	stem_cell_factor	11,27	c-kit	stem cell factor	16590(Tax:10090)	17311(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY role|dep|interaction role|nmod|END_ENTITY	A role for stem_cell_factor -LRB- SCF -RRB- : c-kit interaction -LRB- s -RRB- in the intestinal tract response to Salmonella_typhimurium infection .
8780889	0	c-kit	72,77	stem_cell_factor	154,170	c-kit	stem cell factor	3815	4254	Gene	Gene	receptors|amod|START_ENTITY express|dobj|receptors express|nmod|cells cells|nmod|END_ENTITY	Human osteoclasts and preosteoclast cells -LRB- FLG 29.1 -RRB- express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem_cell_factor .
9004081	0	c-kit	41,46	stem_cell_factor	14,30	c-kit	stem cell factor	3815	17311(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of stem_cell_factor receptor -LRB- c-kit -RRB- by the malignant mast cells from spontaneous canine mast_cell_tumours .
9221761	0	c-kit	56,61	stem_cell_factor	75,91	c-kit	stem cell factor	3815	4254	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Human peripheral blood eosinophils express a functional c-kit receptor for stem_cell_factor that stimulates very late antigen 4 -LRB- VLA-4 -RRB- - mediated cell adhesion to fibronectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- .
9444944	0	c-kit	195,200	stem_cell_factor	30,46	c-kit	stem cell factor	3815	4254	Gene	Gene	subunit|nmod|START_ENTITY phosphorylation|nmod|subunit increase|nmod|phosphorylation Analysis|dep|increase Analysis|nmod|synergism synergism|nmod|END_ENTITY	Analysis of synergism between stem_cell_factor and granulocyte-macrophage_colony-stimulating_factor on human megakaryoblastic cells : an increase in tyrosine phosphorylation of 145 kDa subunit of c-kit in two-factor combination .
9697876	0	c-kit	29,34	stem_cell_factor	60,76	c-kit	stem cell factor	3815	4254	Gene	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor Expression|acl|END_ENTITY	Expression and regulation of c-kit receptor and response to stem_cell_factor in childhood malignant T-lymphoblastic cells .
9746752	0	c-kit	39,44	stem_cell_factor	12,28	c-kit	stem cell factor	3815	4254	Gene	Gene	messenger|appos|START_ENTITY messenger|amod|END_ENTITY	Ontogeny of stem_cell_factor receptor -LRB- c-kit -RRB- messenger ribonucleic_acid in the ovine corpus luteum .
9797132	0	c-kit	49,54	stem_cell_factor	14,30	c-kit	stem cell factor	3815	4254	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of stem_cell_factor and expression of c-kit in human rhabdomyosarcoma cells : lack of autocrine growth modulation .
14667198	0	c-kit	15,20	transforming_growth_factor-beta	61,92	c-kit	transforming growth factor-beta	3815	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Correlation of c-kit expression and cell cycle regulation by transforming_growth_factor-beta in CD34 + CD38 - human bone marrow cells .
7514454	0	c-kit	60,65	tumor_necrosis_factor_alpha	70,97	c-kit	tumor necrosis factor alpha	3815	7124	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the density of the stem_cell_factor receptor -LRB- c-kit -RRB- by tumor_necrosis_factor_alpha on a human myeloid cell line .
7529540	0	c-kit_ligand	34,46	SCF	48,51	c-kit ligand	SCF	4254	4254	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Expression and functional role of c-kit_ligand -LRB- SCF -RRB- in human multiple_myeloma cells .
7512047	0	c-kit_ligand	43,55	Steel_factor	29,41	c-kit ligand	Steel factor	4254	4254	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant human Steel_factor -LRB- c-kit_ligand -RRB- on early cord blood hematopoietic precursors .
1638026	0	c-kit_ligand	35,47	mast_cell_growth_factor	10,33	c-kit ligand	mast cell growth factor	4254	4254	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of mast_cell_growth_factor -LRB- c-kit_ligand -RRB- on clonogenic leukemic precursor cells .
9718862	0	c-kit_receptor	18,32	CD117	34,39	c-kit receptor	CD117	3815	3815	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Thy-1 -LRB- CDw90 -RRB- and c-kit_receptor -LRB- CD117 -RRB- expression on CD34 + hematopoietic_progenitor_cells : a five dimensional flow cytometric study .
10438901	0	c-maf	61,66	IL-4	14,18	c-maf	IL-4	4094	3565	Gene	Gene	require|xcomp|START_ENTITY require|nsubj|production production|compound|END_ENTITY	Cutting edge : IL-4 production by mast cells does not require c-maf .
14688382	0	c-maf	45,50	IL-4	27,31	c-maf	IL-4	4094	3565	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|dobj|induction induction|compound|END_ENTITY	NF-kappa_B_p65 antagonizes IL-4 induction by c-maf in minimal change_nephrotic_syndrome .
14688382	0	c-maf	45,50	NF-kappa_B_p65	0,14	c-maf	NF-kappa B p65	4094	5970	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	NF-kappa_B_p65 antagonizes IL-4 induction by c-maf in minimal change_nephrotic_syndrome .
11222774	0	c-maf	14,19	Pax6	39,43	c-maf	Pax6	54267(Tax:10116)	25509(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of c-maf gene expression by Pax6 in cultured cells .
16890189	0	c-maf	82,87	glutathione_peroxidase-3	54,78	c-maf	glutathione peroxidase-3	17132(Tax:10090)	14778(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Correlation between the expression level of c-maf and glutathione_peroxidase-3 in c-maf - / - mice kidney and c-maf overexpressed renal tubular cells .
16267071	0	c-met	45,50	CD34	16,20	c-met	CD34	4233	947	Gene	Gene	Mobilization|amod|START_ENTITY Mobilization|nmod|END_ENTITY	Mobilization of CD34 -LRB- + -RRB- , CD117 -LRB- + -RRB- , CXCR4 -LRB- + -RRB- , c-met -LRB- + -RRB- stem cells is correlated with left_ventricular_ejection_fraction and plasma NT-proBNP levels in patients with acute_myocardial_infarction .
16646560	0	c-met	25,30	Hepatocyte_growth_factor	0,24	c-met	Hepatocyte growth factor	4233	3082	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Hepatocyte_growth_factor / c-met signaling in regulating urokinase plasminogen activator in human stomach_cancer : A potential therapeutic target for human stomach_cancer .
22095660	0	c-met	25,30	Hepatocyte_growth_factor	0,24	c-met	Hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY required|nsubjpass|signaling END_ENTITY|parataxis|required	Hepatocyte_growth_factor / c-met signaling is required for stem-cell-mediated liver regeneration in mice .
26440443	0	c-met	25,30	Hepatocyte_growth_factor	0,24	c-met	Hepatocyte growth factor	100126565(Tax:9986)	100316908(Tax:9986)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Hepatocyte_growth_factor / c-met promotes proliferation , suppresses apoptosis , and improves matrix metabolism in rabbit nucleus pulposus cells in vitro .
9334823	0	c-met	126,131	Hepatocyte_growth_factor	0,24	c-met	Hepatocyte growth factor	4233	3082	Gene	Gene	levels|nmod|START_ENTITY expressing|dobj|levels cells|acl|expressing stimulates|nmod|cells stimulates|nsubj|END_ENTITY	Hepatocyte_growth_factor stimulates motility , chemotaxis and mitogenesis in ovarian_carcinoma cells expressing high levels of c-met .
9537587	0	c-met	113,118	Hepatocyte_growth_factor	0,24	c-met	Hepatocyte growth factor	4233	3082	Gene	Gene	receptor|amod|START_ENTITY stimulates|nmod|receptor END_ENTITY|parataxis|stimulates	Hepatocyte_growth_factor / scatter factor stimulates chemotaxis and growth of malignant_mesothelioma cells through c-met receptor .
10713700	0	c-met	69,74	hepatocyte_growth_factor	34,58	c-met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional activation of the hepatocyte_growth_factor receptor -LRB- c-met -RRB- gene by its ligand -LRB- hepatocyte_growth_factor -RRB- is mediated through AP-1 .
10713700	0	c-met	69,74	hepatocyte_growth_factor	96,120	c-met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the hepatocyte_growth_factor receptor -LRB- c-met -RRB- gene by its ligand -LRB- hepatocyte_growth_factor -RRB- is mediated through AP-1 .
12042032	0	c-met	75,80	hepatocyte_growth_factor	30,54	c-met	hepatocyte growth factor	24553(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY precedes|dobj|expression precedes|nsubj|Increase Increase|nmod|chain chain|nmod|END_ENTITY	Increase in the beta chain of hepatocyte_growth_factor -LRB- HGF beta -RRB- precedes c-met expression after bleomycin-induced lung_injury in the rat .
12847110	0	c-met	138,143	hepatocyte_growth_factor	25,49	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	receptor|amod|START_ENTITY binding|nmod|receptor independently|advcl|binding inhibits|advmod|independently inhibits|nsubj|domain domain|nmod|END_ENTITY	The N-terminal domain of hepatocyte_growth_factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c-met receptor .
14626426	0	c-met	37,42	hepatocyte_growth_factor	12,36	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	interactions|amod|START_ENTITY role|dep|interactions role|nmod|END_ENTITY	The role of hepatocyte_growth_factor / c-met interactions in the immune system .
15075332	0	c-met	56,61	hepatocyte_growth_factor	167,191	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	phosphorylation|nmod|START_ENTITY regulation|nmod|phosphorylation involves|nsubj|regulation involves|nmod|END_ENTITY	Bi-directional regulation of Ser-985 phosphorylation of c-met via protein_kinase_C and protein phosphatase_2A involves c-Met activation and cellular responsiveness to hepatocyte_growth_factor .
15475459	0	c-met	12,17	hepatocyte_growth_factor	48,72	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	inhibitor|amod|START_ENTITY blocks|nsubj|inhibitor blocks|dobj|loop loop|compound|END_ENTITY	A selective c-met inhibitor blocks an autocrine hepatocyte_growth_factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells .
16144866	0	c-met	98,103	hepatocyte_growth_factor	73,97	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte_growth_factor / c-met axis .
17940345	0	c-met	118,123	hepatocyte_growth_factor	93,117	c-met	hepatocyte growth factor	24553(Tax:10116)	24446(Tax:10116)	Gene	Gene	axis|amod|START_ENTITY Attenuation|dep|axis Attenuation|dep|role role|nmod|END_ENTITY	Attenuation of glycerol-induced acute_kidney_injury by previous partial hepatectomy : role of hepatocyte_growth_factor / c-met axis in tubular protection .
1846706	0	c-met	63,68	hepatocyte_growth_factor	22,46	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	product|amod|START_ENTITY Identification|nmod|product Identification|nmod|receptor receptor|compound|END_ENTITY	Identification of the hepatocyte_growth_factor receptor as the c-met proto-oncogene product .
23715119	0	c-met	49,54	hepatocyte_growth_factor	14,38	c-met	hepatocyte growth factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Activation of hepatocyte_growth_factor receptor , c-met , in renal tubules is required for renoprotection after acute_kidney_injury .
24052949	0	c-met	127,132	hepatocyte_growth_factor	102,126	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	expansion|dep|START_ENTITY expansion|nmod|END_ENTITY	Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte_growth_factor / c-met and STAT3 .
25187433	0	c-met	137,142	hepatocyte_growth_factor	112,136	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	The procognitive and synaptogenic effects of angiotensin_IV-derived peptides are dependent on activation of the hepatocyte_growth_factor / c-met system .
8067383	0	c-met	48,53	hepatocyte_growth_factor	23,47	c-met	hepatocyte growth factor	24553(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Regional expression of hepatocyte_growth_factor / c-met in experimental renal_hypertrophy and hyperplasia .
8640940	0	c-met	106,111	hepatocyte_growth_factor	81,105	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	transforming_growth_factor_alpha|amod|START_ENTITY transforming_growth_factor_alpha|dep|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Expression of transforming_growth_factor_alpha / epidermal_growth_factor_receptor , hepatocyte_growth_factor / c-met and acidic_fibroblast_growth_factor / fibroblast growth factor receptors during hepatocarcinogenesis .
8707284	0	c-met	137,142	hepatocyte_growth_factor	6,30	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	does|nsubj|START_ENTITY correlate|parataxis|does correlate|nsubj|END_ENTITY	Liver hepatocyte_growth_factor does not always correlate with hepatocellular proliferation in human liver lesions : its specific receptor c-met does .
8888500	0	c-met	109,114	hepatocyte_growth_factor	23,47	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	expression|amod|START_ENTITY result|nmod|expression result|nsubj|effects effects|nmod|cells cells|amod|END_ENTITY	Synergistic effects of hepatocyte_growth_factor on human cord blood CD34 + progenitor cells are the result of c-met receptor expression .
9049208	0	c-met	61,66	hepatocyte_growth_factor	14,38	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	proto-oncogene|amod|START_ENTITY Expression|appos|proto-oncogene Expression|nmod|END_ENTITY	Expression of hepatocyte_growth_factor and its receptor , the c-met proto-oncogene , in_hepatocellular_carcinoma .
9142219	0	c-met	46,51	hepatocyte_growth_factor	21,45	c-met	hepatocyte growth factor	24553(Tax:10116)	24446(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY Modifications|dep|pathway Modifications|nmod|END_ENTITY	Modifications of the hepatocyte_growth_factor / c-met pathway by constitutive expression of transforming_growth_factor-alpha in rat liver epithelial cells .
9211490	0	c-met	0,5	hepatocyte_growth_factor	53,77	c-met	hepatocyte growth factor	4233	3082	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	c-met expression in pancreatic_cancer and effects of hepatocyte_growth_factor on pancreatic_cancer cell growth .
16099863	0	c-met	17,22	hypoxia-inducible_factor-1alpha	64,95	c-met	hypoxia-inducible factor-1alpha	4233	3091	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of c-met protooncogene product expression through hypoxia-inducible_factor-1alpha is involved in trophoblast invasion under low-oxygen tension .
9920903	0	c-met	18,23	p53	51,54	c-met	p53	4233	7157	Gene	Gene	promoter|amod|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the c-met proto-oncogene promoter by p53 .
7678980	0	c-met	34,39	scatter_factor	94,108	c-met	scatter factor	17295(Tax:10090)	15234(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|dep|Expression	Expression of the proto-oncogenes c-met and c-kit and their ligands , hepatocyte_growth_factor / scatter_factor and stem_cell_factor , in SCLC cell lines and xenografts .
11212247	0	c-mos	26,31	p53	85,88	c-mos	p53	4342	7157	Gene	Gene	expression|nmod|START_ENTITY expression|dep|relationship relationship|nmod|status status|compound|END_ENTITY	Deregulated expression of c-mos in non-small_cell_lung_carcinomas : relationship with p53 status , genomic instability , and tumor kinetics .
8020956	0	c-mpl	41,46	MPL	53,56	c-mpl	MPL	4352	4352	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and transcription of the human c-mpl gene -LRB- MPL -RRB- .
11478766	0	c-mpl	66,71	Thrombopoietin	0,14	c-mpl	Thrombopoietin	4352	7066	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Thrombopoietin induces histidine_decarboxylase gene expression in c-mpl transfected UT7 cells .
11478766	0	c-mpl	66,71	histidine_decarboxylase	23,46	c-mpl	histidine decarboxylase	4352	3067	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Thrombopoietin induces histidine_decarboxylase gene expression in c-mpl transfected UT7 cells .
10460590	0	c-mpl	48,53	thrombopoietin	15,29	c-mpl	thrombopoietin	4352	7066	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Interaction of thrombopoietin with the platelet c-mpl receptor in plasma : binding , internalization , stability and pharmacokinetics .
14995067	0	c-mpl	20,25	thrombopoietin	45,59	c-mpl	thrombopoietin	4352	7066	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of human c-mpl gene expression by thrombopoietin through protein kinase C .
15102474	0	c-mpl	110,115	thrombopoietin	68,82	c-mpl	thrombopoietin	4352	7066	Gene	Gene	lacking|dobj|START_ENTITY necessary|xcomp|lacking necessary|nmod|action action|nmod|END_ENTITY	A functional erythropoietin_receptor is necessary for the action of thrombopoietin on erythroid cells lacking c-mpl .
8759880	0	c-mpl	27,32	thrombopoietin	34,48	c-mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY Activity|nmod|ligand Activity|acl|END_ENTITY	Activity of the ligand for c-mpl , thrombopoietin , in early haemopoiesis .
8784480	0	c-mpl	8,13	thrombopoietin	75,89	c-mpl	thrombopoietin	4352	7066	Gene	Gene	transcripts|amod|START_ENTITY Lack|nmod|transcripts Lack|nmod|END_ENTITY	Lack of c-mpl proto-oncogene transcripts and growth-stimulatory effects of thrombopoietin on human small_cell_lung_cancer cell lines .
9196139	0	c-mpl	14,19	thrombopoietin	43,57	c-mpl	thrombopoietin	4352	7066	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|receptor receptor|nmod|END_ENTITY	Expression of c-mpl mRNA , the receptor for thrombopoietin , in acute_myeloid_leukemia blasts identifies a group of patients with poor response to intensive chemotherapy .
9446653	0	c-mpl	33,38	thrombopoietin	115,129	c-mpl	thrombopoietin	17480(Tax:10090)	21832(Tax:10090)	Gene	Gene	Thrombopoietin|appos|START_ENTITY expressed|nsubjpass|Thrombopoietin expressed|nmod|cells cells|dep|evidence evidence|nmod|END_ENTITY	Thrombopoietin and its receptor , c-mpl , are constitutively expressed by mouse liver endothelial cells : evidence of thrombopoietin as a growth factor for liver endothelial cells .
9737683	0	c-mpl	170,175	thrombopoietin	91,105	c-mpl	thrombopoietin	4352	7066	Gene	Gene	UT-7|dep|START_ENTITY lines|amod|UT-7 mechanisms|nmod|lines regulated|nmod|mechanisms regulated|nsubjpass|Inhibition Inhibition|nmod|differentiation differentiation|nmod|differentiation differentiation|nmod|END_ENTITY	Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7 / c-mpl and TF-1 / c-mpl cell lines .
9737683	0	c-mpl	185,190	thrombopoietin	91,105	c-mpl	thrombopoietin	4352	7066	Gene	Gene	lines|amod|START_ENTITY mechanisms|nmod|lines regulated|nmod|mechanisms regulated|nsubjpass|Inhibition Inhibition|nmod|differentiation differentiation|nmod|differentiation differentiation|nmod|END_ENTITY	Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7 / c-mpl and TF-1 / c-mpl cell lines .
9260579	0	c-mpl_ligand	27,39	thrombopoietin	11,25	c-mpl ligand	thrombopoietin	7066	7066	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of thrombopoietin -LRB- c-mpl_ligand -RRB- on growth of blast cells from patients with transient abnormal_myelopoiesis and acute_myeloblastic_leukemia .
8634438	0	c-myb	29,34	A-myb	14,19	c-myb	A-myb	4602	4603	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of A-myb , but not c-myb and B-myb , is restricted to Burkitt 's _ lymphoma , sIg + B-acute_lymphoblastic_leukemia , and a subset of chronic_lymphocytic_leukemias .
1776859	0	c-myb	29,34	C-myc	0,5	c-myc	C-myc	4609	4609	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	C-myc overexpression , c-mil , c-myb expression in a breast_tumor cell line .
9357978	0	c-myb	48,53	CBP	74,77	c-myb	CBP	4602	1387	Gene	Gene	interactions|nmod|START_ENTITY Mapping|nmod|interactions END_ENTITY|nsubj|Mapping	Mapping of protein-protein interactions between c-myb and its coactivator CBP by a new phage display technique .
3316384	0	c-myb	28,33	L3T4	61,65	c-myb	L3T4	17863(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Molecular basis of elevated c-myb expression in the abnormal L3T4 - , Lyt-2 - T lymphocytes of autoimmune mice .
3116095	0	c-myb	33,38	Lyt-2	63,68	c-myb	Lyt-2	17863(Tax:10090)	12525(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	The expression and regulation of c-myb transcription in B6/lpr Lyt-2 - , L3T4-T lymphocytes .
8630096	0	c-myb	52,57	ML-1	77,81	c-myb	ML-1	4602	112744	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Induction of differentiation and down-regulation of c-myb gene expression in ML-1 human myeloblastic_leukemia cells by the clinically effective anti-leukemia agent meisoindigo .
9717674	0	c-myb	26,31	MRP14	84,89	c-myb	MRP14	4602	6280	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	The transcription factors c-myb and C/EBP _ alpha regulate the monocytic/myeloic gene MRP14 .
22829978	0	c-myb	23,28	Meis1	55,60	c-myb	Meis1	17863(Tax:10090)	17268(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Distinct regulation of c-myb gene expression by HoxA9 , Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells .
7559553	0	c-myb	18,23	WT1	32,35	c-myb	WT1	4602	7490	Gene	Gene	gene|amod|START_ENTITY gene|nmod|protein protein|compound|END_ENTITY	Repression of the c-myb gene by WT1 protein in T and B cell lines .
1588953	0	c-myb	12,17	c-myc	113,118	c-myb	c-myc	4602	4609	Gene	Gene	disrupts|amod|START_ENTITY myeloid|nsubj|disrupts myeloid|dobj|differentiation differentiation|advmod|prior prior|advcl|END_ENTITY	Deregulated c-myb disrupts interleukin-6 - or leukemia_inhibitory_factor-induced myeloid differentiation prior to c-myc : role in leukemogenesis .
16683403	0	c-myc	54,59	Bcl-2	15,20	c-myc	Bcl-2	4609	596	Gene	Gene	gene|amod|START_ENTITY Expression|nmod|gene Expression|nmod|protein protein|compound|END_ENTITY	-LSB- Expression of Bcl-2 protein and the amplification of c-myc gene in patients with chronic_myeloid_leukemia -RSB- .
17487378	0	c-myc	44,49	Bcl-2	65,70	c-myc	Bcl-2	4609	596	Gene	Gene	index|amod|START_ENTITY abundance|dobj|index abundance|dep|-RSB- -RSB-|parataxis|correlates correlates|compound|END_ENTITY	The interactive transcript abundance index -LSB- c-myc * p73alpha -RSB- / -LSB- p21 * Bcl-2 -RSB- correlates with baseline level of apoptosis and response to CPT-11 in human bronchogenic_carcinoma cell lines .
15810077	0	c-myc	54,59	Beta-catenin	0,12	c-myc	Beta-catenin	4609	1499	Gene	Gene	cyclinD1|amod|START_ENTITY expression|nmod|cyclinD1 up-regulates|dep|expression up-regulates|amod|END_ENTITY	Beta-catenin up-regulates the expression of cyclinD1 , c-myc and MMP-7 in human pancreatic_cancer : relationships with carcinogenesis and metastasis .
17877160	0	c-myc	15,20	Blimp-1	35,42	c-myc	Blimp-1	4609	639	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Regulation of c-myc expression by Blimp-1 during the differentiation of myeloma cells -RSB- .
2076099	0	c-myc	7,12	C-fos	0,5	c-myc	C-fos	4609	2353	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	C-fos , c-myc and IL-2R mRNA expression in PHA activated T lymphocytes treated with a monoclonal anti-HLA class I antibody -LRB- MAb 01.65 -RRB- .
3106791	0	c-myc	0,5	CD2	72,75	c-myc	CD2	4609	914	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	c-myc gene expression and interleukin-2 receptor levels in cloned human CD2 + , CD3 + and CD2 + , CD3 - lymphocytes .
23178487	0	c-myc	49,54	CPEB	141,145	c-myc	CPEB	4609	64506	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic_polyadenylation_element-binding_protein CPEB .
3091845	0	c-myc	99,104	E1A	114,117	c-myc	E1A	24577(Tax:10116)	25244(Tax:10116)	Gene	Gene	proteins|amod|START_ENTITY proteins|nummod|END_ENTITY	How reliable is amino_acid sequence homology in predicting similarity of structure and function of c-myc and Ad12 E1A oncogenic proteins ?
1714718	0	c-myc	50,55	EGF	78,81	c-myc	EGF	24577(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Prostaglandins E2 and F2a mediate the increase in c-myc expression induced by EGF in primary rat hepatocyte cultures .
15367674	0	c-myc	40,45	FLIP	21,25	c-myc	FLIP	4609	8837	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity .
12460470	0	c-myc	91,96	H-ras	65,70	c-myc	H-ras	4609	3265	Gene	Gene	genes|appos|START_ENTITY myc|dobj|genes myc|nsubj|analysis analysis|appos|genes genes|appos|N-ras N-ras|dep|END_ENTITY	Molecular analysis of oncogenes , ras family genes -LRB- N-ras , K-ras , H-ras -RRB- , myc family genes -LRB- c-myc , N-myc -RRB- and mdm2 in natural killer cell neoplasms .
9839551	0	c-myc	44,49	HLA-B	26,31	c-myc	HLA-B	4609	3106	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Repression of the minimal HLA-B promoter by c-myc and p53 occurs through independent mechanisms .
9457064	0	c-myc	42,47	Insulin-like_growth_factor_I	0,28	c-myc	Insulin-like growth factor I	511077(Tax:9913)	104978413	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Insulin-like_growth_factor_I induction of c-myc expression in bovine fibroblasts can be blocked by antecedent insulin_receptor activation .
1901940	0	c-myc	157,162	Interleukin-6	0,13	c-myc	Interleukin-6	4609	3569	Gene	Gene	blocked|nmod|START_ENTITY blocked|nsubjpass|differentiation differentiation|amod|END_ENTITY	Interleukin-6 - and leukemia_inhibitory_factor-induced terminal differentiation of myeloid_leukemia cells is blocked at an intermediate stage by constitutive c-myc .
2346497	0	c-myc	25,30	Interleukin-6	0,13	c-myc	Interleukin-6	4609	3569	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates c-myc expression and proliferation of cultured vascular smooth muscle cells .
22826122	0	c-myc	99,104	K-Ras	0,5	c-myc	K-Ras	4609	3845	Gene	Gene	up-regulation|nmod|START_ENTITY inhibit|nmod|up-regulation inhibit|nsubj|oncogenes oncogenes|amod|END_ENTITY	K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc .
12460470	0	c-myc	91,96	K-ras	58,63	c-myc	K-ras	4609	3845	Gene	Gene	genes|appos|START_ENTITY myc|dobj|genes myc|nsubj|analysis analysis|appos|genes genes|appos|N-ras N-ras|dep|END_ENTITY	Molecular analysis of oncogenes , ras family genes -LRB- N-ras , K-ras , H-ras -RRB- , myc family genes -LRB- c-myc , N-myc -RRB- and mdm2 in natural killer cell neoplasms .
7700652	0	c-myc	41,46	Max	22,25	c-myc	Max	4609	4149	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|compound|END_ENTITY	Analysis of c-Myc and Max binding to the c-myc promoter : evidence that autosuppression occurs via an indirect mechanism .
1374683	0	c-myc	21,26	N-myc	14,19	c-myc	N-myc	4609	4613	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|appos|proteins	Expression of N-myc , c-myc , and MDR-1 proteins in newly established neuroblastoma cell lines : a study by immunofluorescence staining and flow cytometry .
11802993	0	c-myc	75,80	P53	70,73	c-myc	P53	4609	7157	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|appos|proteins	-LSB- Expression of surviving gene and its relationship with expression of P53 , c-myc , k-ras proteins in non-small-cell lung_cancer -RSB- .
20423888	0	c-myc	15,20	PC-1	1,5	c-myc	PC-1	4609	7163	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	-LSB- PC-1 enhances c-myc gene expression in prostate_cancer cells -RSB- .
10415336	0	c-myc	33,38	PTEN	0,4	c-myc	PTEN	4609	5728	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	PTEN transcriptionally modulates c-myc gene expression in human breast_carcinoma cells and is involved in cell growth regulation .
9178906	0	c-myc	0,5	RCC1	16,20	c-myc	RCC1	4609	1104	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nummod|END_ENTITY	c-myc activates RCC1 gene expression through E-box elements .
21251405	0	c-myc	45,50	Skp2	15,19	c-myc	Skp2	4609	6502	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of Skp2 and its correlation with c-myc in non-small_cell_lung_cancer -RSB- .
11847100	0	c-myc	54,59	Src	24,27	c-myc	Src	4609	6714	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis .
18056446	0	c-myc	0,5	TSC2	20,24	c-myc	TSC2	4609	7249	Gene	Gene	Repression|amod|START_ENTITY Repression|nmod|END_ENTITY	c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation .
23178487	0	c-myc	49,54	Tob	26,29	c-myc	Tob	4609	10140	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic_polyadenylation_element-binding_protein CPEB .
3097823	0	c-myc	30,35	Tumor_necrosis_factor	0,21	c-myc	Tumor necrosis factor	4609	7124	Gene	Gene	expression|amod|START_ENTITY reduces|dobj|expression reduces|nsubj|END_ENTITY	Tumor_necrosis_factor reduces c-myc expression and cooperates with interferon-gamma in HeLa cells .
2359342	0	c-myc	43,48	Tumor_necrosis_factor_alpha	0,27	c-myc	Tumor necrosis factor alpha	4609	7124	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha down-regulates c-myc mRNA expression and induces in vitro monocytic differentiation in fresh blast cells from patients with acute_myeloblastic_leukemia .
23588859	0	c-myc	0,5	VEGF	49,53	c-myc	VEGF	4609	7422	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	c-myc but not Hif-1a-dependent downregulation of VEGF influences the proliferation and differentiation of HL-60 cells induced by ATRA .
1713357	0	c-myc	43,48	Vasoactive_intestinal_polypeptide	0,33	c-myc	Vasoactive intestinal polypeptide	4609	7432	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Vasoactive_intestinal_polypeptide inhibits c-myc expression and growth of human gastric_carcinoma cells .
17434929	0	c-myc	59,64	YY1	111,114	c-myc	YY1	4609	7528	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1 .
23617883	0	c-myc	114,119	angiopoietin-like_4	129,148	c-myc	angiopoietin-like 4	4609	51129	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Epidermal_growth_factor_receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like_4 expression in malignant_glioma .
16091746	0	c-myc	55,60	aryl_hydrocarbon_receptor	4,29	c-myc	aryl hydrocarbon receptor	4609	196	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor constitutively represses c-myc transcription in human mammary_tumor cells .
10567899	0	c-myc	0,5	bcl-2	108,113	c-myc	bcl-2	4609	596	Gene	Gene	genes|amod|START_ENTITY genes|dep|evidence evidence|nmod|link link|nmod|over-expression over-expression|amod|END_ENTITY	c-myc , p53 and bcl-2 , apoptosis-related genes in infiltrating breast_carcinomas : evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients .
11778549	0	c-myc	36,41	bcl-2	96,101	c-myc	bcl-2	4609	596	Gene	Gene	antisense|xcomp|START_ENTITY antisense|nmod|expression expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The effects of RA538 and antisense c-myc on cervical cancer cell lines with high expression of bcl-2 gene -RSB- .
12536628	0	c-myc	22,27	bcl-2	15,20	c-myc	bcl-2	4609	596	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	-LSB- Expression of bcl-2 , c-myc genes and their relationship in patients with acute_leukemia -RSB- .
1406975	0	c-myc	32,37	bcl-2	54,59	c-myc	bcl-2	4609	596	Gene	Gene	induced|advcl|START_ENTITY death|acl|induced inhibited|nsubj|death inhibited|advcl|END_ENTITY	Apoptotic cell death induced by c-myc is inhibited by bcl-2 .
17145575	0	c-myc	76,81	bcl-2	70,75	c-myc	bcl-2	4609	596	Gene	Gene	ASODNs|amod|START_ENTITY ASODNs|amod|END_ENTITY	Enhancing radiosensitivity of Hela cells by combining transfection of bcl-2 c-myc ASODNs .
2284100	0	c-myc	25,30	bcl-2	51,56	c-myc	bcl-2	4609	596	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|line line|amod|END_ENTITY	Concurrent activation of c-myc and inactivation of bcl-2 by chromosomal translocation in a lymphoblastic_lymphoma cell line .
8943742	0	c-myc	70,75	bcl-2	14,19	c-myc	bcl-2	4609	596	Gene	Gene	comparison|nmod|START_ENTITY Expression|dep|comparison Expression|nmod|oncoprotein oncoprotein|amod|END_ENTITY	Expression of bcl-2 oncoprotein in pituitary_tumours : comparison with c-myc .
9310122	0	c-myc	27,32	bcl-2	20,25	c-myc	bcl-2	4609	596	Gene	Gene	proliferation|amod|START_ENTITY proliferation|amod|END_ENTITY	Cell proliferation , bcl-2 , c-myc , p53 and apoptosis as indicators of different aggressiveness in small_lymphocytic_lymphoma -LRB- SLL -RRB- .
17136310	0	c-myc	82,87	beta-catenin	41,53	c-myc	beta-catenin	24577(Tax:10116)	84353(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells .
8063836	0	c-myc	14,19	c-Abl	34,39	c-myc	c-Abl	4609	25	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of c-myc expression by c-Abl is independent of both the DNA binding function of c-Abl and the c-myc EP site .
10604737	0	c-myc	17,22	c-erbB-2	126,134	c-myc	c-erbB-2	4609	2064	Gene	Gene	amplification|amod|START_ENTITY Determination|nmod|amplification Determination|dep|evaluation evaluation|nmod|value value|nmod|characteristics characteristics|amod|END_ENTITY	Determination of c-myc amplification and overexpression in breast_cancer patients : evaluation of its prognostic value against c-erbB-2 , cathepsin-D and clinicopathological characteristics using univariate and multivariate analysis .
1348967	0	c-myc	0,5	c-erbB-2	7,15	c-myc	c-erbB-2	4609	2064	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	c-myc , c-erbB-2 , and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast_carcinoma .
1349907	0	c-myc	70,75	c-erbB-2	60,68	c-myc	c-erbB-2	4609	2064	Gene	Gene	p21|amod|START_ENTITY p21|amod|END_ENTITY	Preliminary study on oncogene product immunohistochemistry -LRB- c-erbB-2 , c-myc , ras p21 , EGFR -RRB- in breast pathology .
7780818	0	c-myc	15,20	c-erbB-2	22,30	c-myc	c-erbB-2	4609	2064	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	-LSB- Expression of c-myc , c-erbB-2 , insulin-like growth factor II andepidermal growth factor receptor in hepatitis_B , cirrhosis and hepatocellular_carcinoma -RSB- .
8096798	0	c-myc	17,22	c-erbB-2	34,42	c-myc	c-erbB-2	4609	2064	Gene	Gene	START_ENTITY|neg|not not|advcl|END_ENTITY	Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast_cancer .
1348920	0	c-myc	13,18	c-fos	38,43	c-myc	c-fos	4609	2353	Gene	Gene	Oncoprotein|dep|START_ENTITY Oncoprotein|amod|END_ENTITY	Oncoprotein -LRB- c-myc , c-erbB1 , c-erbB2 , c-fos -RRB- and suppressor gene product -LRB- p53 -RRB- expression in squamous_cell_carcinomas of the lung .
2261575	0	c-myc	25,30	c-fos	46,51	c-myc	c-fos	4609	2353	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Sodium_butyrate inhibits c-myc and stimulates c-fos expression in all the steps of the cell-cycle in hepatoma tissue cultured cells .
3096504	0	c-myc	149,154	c-fos	122,127	c-myc	c-fos	4609	2353	Gene	Gene	-RSB-|amod|START_ENTITY followed|nmod|-RSB- oncogene|acl|followed oncogene|amod|END_ENTITY	-LSB- Stimulation of human lymphocytes by phorbol_acetate and a calcium ionophore induces an early transient expression of the c-fos oncogene followed by c-myc -RSB- .
3144696	0	c-myc	57,62	c-fos	24,29	c-myc	c-fos	24577(Tax:10116)	314322(Tax:10116)	Gene	Gene	hepatocytes|amod|START_ENTITY expression|nmod|hepatocytes expression|nmod|expression expression|amod|END_ENTITY	Transient expression of c-fos and constant expression of c-myc in freshly isolated and cultured normal adult rat hepatocytes .
6334806	0	c-myc	77,82	c-fos	13,18	c-myc	c-fos	4609	2353	Gene	Gene	activation|nmod|START_ENTITY precedes|dobj|activation precedes|nsubj|Induction Induction|nmod|gene gene|amod|END_ENTITY	Induction of c-fos gene and protein by growth factors precedes activation of c-myc .
7866900	0	c-myc	141,146	c-fos	148,153	c-myc	c-fos	4609	2353	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Low-dose recombinant human tumor necrosis-alpha in HL-60 leukemic cell line : effect on induced differentiation and regulating expression of c-myc , c-fos proto-oncogenes -RSB- .
1588953	0	c-myc	113,118	c-myb	12,17	c-myc	c-myb	4609	4602	Gene	Gene	prior|advcl|START_ENTITY differentiation|advmod|prior myeloid|dobj|differentiation myeloid|nsubj|disrupts disrupts|amod|END_ENTITY	Deregulated c-myb disrupts interleukin-6 - or leukemia_inhibitory_factor-induced myeloid differentiation prior to c-myc : role in leukemogenesis .
2825967	0	c-myc	51,56	c-myc	8,13	c-myc	c-myc	4609	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	In situ c-myc expression and genomic status of the c-myc locus in infiltrating ductal_carcinomas of the breast .
2825967	0	c-myc	8,13	c-myc	51,56	c-myc	c-myc	4609	4609	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	In situ c-myc expression and genomic status of the c-myc locus in infiltrating ductal_carcinomas of the breast .
11596289	0	c-myc	166,171	c-sis	159,164	c-myc	c-sis	24577(Tax:10116)	24628(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of 1 - -LRB- 2,6-dimethylphenoxy -RRB- -2 - -LRB- 3,4-dimethoxyphenylethylamino -RRB- _ propane_hydrochloride on proliferation of vascular smooth muscle cells and PDGF-B , bFGF , c-sis , c-myc in spontaneously hypertensive rat -RSB- .
9001421	0	c-myc	31,36	cyclin_D1	152,161	c-myc	cyclin D1	4609	595	Gene	Gene	transcription|amod|START_ENTITY controls|dobj|transcription controls|nmod|BCR-ABL BCR-ABL|acl|transformed transformed|dobj|cells cells|dep|activity activity|acl|exerted exerted|nmod|END_ENTITY	Cyclic_AMP negatively controls c-myc transcription and G1 cell cycle progression in p210 BCR-ABL transformed cells : inhibitory activity exerted through cyclin_D1 and cdk4 .
1646047	0	c-myc	14,19	granulocyte-macrophage_colony-stimulating_factor	34,82	c-myc	granulocyte-macrophage colony-stimulating factor	4609	1437	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of c-myc expression by granulocyte-macrophage_colony-stimulating_factor in human leukemia cells .
2480191	0	c-myc	47,52	growth_hormone	11,25	c-myc	growth hormone	24577(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of growth_hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver_carcinogenesis in the resistant hepatocyte model .
14570602	0	c-myc	92,97	hTERT	25,30	c-myc	hTERT	4609	7015	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Expression of telomerase hTERT in human non-small cell lung_cancer and its correlation with c-myc gene .
25873431	0	c-myc	51,56	hTERT	30,35	c-myc	hTERT	4609	7015	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Acidified bile_acids increase hTERT expression via c-myc activation in human gastric_cancer cells .
25873431	0	c-myc	51,56	hTERT	30,35	c-myc	hTERT	4609	7015	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Acidified bile_acids increase hTERT expression via c-myc activation in human gastric_cancer cells .
6818551	0	c-myc	21,26	immunoglobulin_heavy_chain	41,67	c-myc	immunoglobulin heavy chain	4609	3495	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Translocation of the c-myc gene into the immunoglobulin_heavy_chain locus in human Burkitt_lymphoma and murine plasmacytoma cells .
1588953	0	c-myc	113,118	interleukin-6	27,40	c-myc	interleukin-6	4609	3569	Gene	Gene	prior|advcl|START_ENTITY differentiation|advmod|prior myeloid|dobj|differentiation myeloid|nsubj|disrupts disrupts|amod|END_ENTITY	Deregulated c-myb disrupts interleukin-6 - or leukemia_inhibitory_factor-induced myeloid differentiation prior to c-myc : role in leukemogenesis .
11802993	0	c-myc	75,80	k-ras	82,87	c-myc	k-ras	4609	3845	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	-LSB- Expression of surviving gene and its relationship with expression of P53 , c-myc , k-ras proteins in non-small-cell lung_cancer -RSB- .
25025684	0	c-myc	44,49	microRNA-135b	22,35	c-myc	microRNA-135b	4609	442891	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	The tumor-suppressive microRNA-135b targets c-myc in osteoscarcoma .
2332674	0	c-myc	40,45	myc	30,33	c-myc	myc	4609	4609	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	-LSB- A study of amplifications of myc gene -LRB- c-myc and N-myc -RRB- in human ovarian_cancer -RSB- .
10072196	0	c-myc	15,20	ornithine_decarboxylase	73,96	c-myc	ornithine decarboxylase	24577(Tax:10116)	24609(Tax:10116)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Involvement of c-myc and max in CNS beta-endorphin modulation of hepatic ornithine_decarboxylase responsiveness to insulin in rat pups .
11598794	0	c-myc	19,24	ornithine_decarboxylase	127,150	c-myc	ornithine decarboxylase	4609	4953	Gene	Gene	expression|amod|START_ENTITY Down-modulation|nmod|expression protects|nsubj|Down-modulation protects|parataxis|role role|nmod|END_ENTITY	Down-modulation of c-myc expression by phorbol_ester protects CEM T leukaemia cells from starvation-induced apoptosis : role of ornithine_decarboxylase and polyamines .
8551363	0	c-myc	118,123	ornithine_decarboxylase	52,75	c-myc	ornithine decarboxylase	24577(Tax:10116)	24609(Tax:10116)	Gene	Gene	downregulation|nmod|START_ENTITY END_ENTITY|nmod|downregulation	Neonatal deprivation of maternal touch may suppress ornithine_decarboxylase via downregulation of the proto-oncogenes c-myc and max .
23158280	0	c-myc	72,77	p14	15,18	c-myc	p14	4609	11102	Gene	Gene	-RSB-|amod|START_ENTITY apoptosis|nmod|-RSB- apoptosis|nsubj|Regulation Regulation|nmod|expression expression|amod|END_ENTITY	-LSB- Regulation of p14 -LRB- ARF -RRB- expression and induction of cell apoptosis with c-myc in a p53-independent pathway -RSB- .
19575869	0	c-myc	24,29	p16	36,39	c-myc	p16	4609	1029	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	-LSB- Abnormal expression of c-myc , p53 , p16 protein and GNAS1 gene mutation in fibrous_dysplasia -RSB- .
10498900	0	c-myc	153,158	p53	42,45	c-myc	p53	4609	7157	Gene	Gene	relationship|nmod|START_ENTITY effect|dep|relationship TNF|nmod|effect TNF|nsubj|transfer transfer|nmod|sensitizes sensitizes|compound|END_ENTITY	Adenovirus-mediated transfer of wild-type p53 gene sensitizes TNF resistant MCF7 derivatives to the cytotoxic effect of this cytokine : relationship with c-myc and Rb .
10567899	0	c-myc	0,5	p53	7,10	c-myc	p53	4609	7157	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	c-myc , p53 and bcl-2 , apoptosis-related genes in infiltrating breast_carcinomas : evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients .
1334053	0	c-myc	47,52	p53	42,45	c-myc	p53	4609	7157	Gene	Gene	ploidy|compound|START_ENTITY END_ENTITY|dep|ploidy	Quantitation of biological tumor markers -LRB- p53 , c-myc , Ki-67 and DNA ploidy -RRB- by multiparameter flow cytometry in non-small-cell_lung_cancer .
15839202	0	c-myc	119,124	p53	82,85	c-myc	p53	4609	7157	Gene	Gene	-RSB-|amod|START_ENTITY expression|nmod|-RSB- expression|compound|p21 p21|compound|END_ENTITY	-LSB- Coordination inhibition of the proliferation of MCF-7 by enhancing expression of p53 , p21 and decreasing expression of c-myc -RSB- .
19575869	0	c-myc	24,29	p53	31,34	c-myc	p53	4609	7157	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	-LSB- Abnormal expression of c-myc , p53 , p16 protein and GNAS1 gene mutation in fibrous_dysplasia -RSB- .
22039300	0	c-myc	132,137	p53	2,5	c-myc	p53	4609	22060(Tax:10090)	Gene	Gene	transgene|amod|START_ENTITY carrying|dobj|transgene mice|acl|carrying lymphomagenesis|nmod|mice sensitizes|nmod|lymphomagenesis sensitizes|nsubj|defect defect|compound|END_ENTITY	A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3 ' regulatory region-driven c-myc transgene .
23177619	0	c-myc	24,29	p53	46,49	c-myc	p53	4609	7157	Gene	Gene	WAF/CIP1|amod|START_ENTITY analysis|nmod|WAF/CIP1 analysis|appos|proteins proteins|compound|END_ENTITY	Correlation analysis of c-myc , p21 -LRB- WAF/CIP1 -RRB- , p53 , C-erbB-2 and COX-2 proteins in esophageal_squamous_cell_carcinoma .
25536625	0	c-myc	44,49	p53	34,37	c-myc	p53	4609	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of p53 , p63 , c-myc , p21 -LRB- WAF1/cip1 -RRB- and p27 -LRB- kip1 -RRB- proteins in urothelial_bladder_carcinoma : correlation with clinicopathological parameters .
7907610	0	c-myc	5,10	p53	0,3	c-myc	p53	4609	7157	Gene	Gene	p62|amod|START_ENTITY END_ENTITY|appos|p62	p53 , c-myc p62 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in non-Hodgkin 's _ lymphomas .
8016082	0	c-myc	0,5	p53	50,53	c-myc	p53	4609	7157	Gene	Gene	p53|amod|START_ENTITY function|nsubj|p53 function|advcl|altering altering|dobj|trafficking trafficking|compound|END_ENTITY	c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle .
8547828	0	c-myc	36,41	p53	31,34	c-myc	p53	4609	7157	Gene	Gene	oncoproteins|amod|START_ENTITY exposed|nsubj|oncoproteins exposed|advcl|Variation Variation|nmod|expression expression|nmod|END_ENTITY	Variation in the expression of p53 , c-myc , and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine .
8574164	0	c-myc	15,20	p53	0,3	c-myc	p53	4609	7157	Gene	Gene	rearrangements|amod|START_ENTITY mutations|appos|rearrangements mutations|compound|END_ENTITY	p53 mutations , c-myc and bcl-2 rearrangements in human non-Hodgkin 's _ lymphoma cell lines .
9196053	0	c-myc	40,45	p53	105,108	c-myc	p53	4609	7157	Gene	Gene	gene|amod|START_ENTITY activation|nmod|gene activation|nmod|proteins proteins|amod|binding binding|nmod|END_ENTITY	Transcriptional activation of the human c-myc gene by simian_virus_40 large T antigen without binding to p53 and RB proteins in the transient expression system .
9399658	0	c-myc	87,92	p53	14,17	c-myc	p53	4609	7157	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Heterogeneous p53 mutations in a Burkitt_lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements .
9632756	0	c-myc	14,19	p53	53,56	c-myc	p53	4609	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|mutants mutants|compound|END_ENTITY	Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain .
9816266	0	c-myc	22,27	p53	149,152	c-myc	p53	4609	7157	Gene	Gene	proto-oncogene|amod|START_ENTITY Overexpression|nmod|proto-oncogene associated|nsubjpass|Overexpression associated|nmod|mortality mortality|acl:relcl|abrogated abrogated|nmod|mutation mutation|nmod|gene gene|compound|END_ENTITY	Overexpression of the c-myc proto-oncogene in colorectal_carcinoma is associated with a reduced mortality that is abrogated by point mutation of the p53 tumor suppressor gene .
1874294	0	c-myc	61,66	p62	57,60	c-myc	p62	4609	23636	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Use of the OM-11-906 monoclonal antibody for determining p62 c-myc expression by flow cytometry in relation to prognosis in colorectal_cancer .
2200214	0	c-myc	69,74	p62	65,68	c-myc	p62	4609	23636	Gene	Gene	oncogene|amod|START_ENTITY oncogene|amod|END_ENTITY	Comparison of deoxyribonucleic_acid ploidy and nuclear expressed p62 c-myc oncogene in the prognosis of colorectal_cancer .
9348182	0	c-myc	54,59	preproendothelin-1	27,45	c-myc	preproendothelin-1	24577(Tax:10116)	24323(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Biphasic regulation of the preproendothelin-1 gene by c-myc .
9219032	0	c-myc	104,109	scFv	33,37	c-myc	scFv	4609	652070	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Primary structure and functional scFv antibody expression of an antibody against the human protooncogen c-myc .
15645079	0	c-myc	67,72	telomerase_reverse_transcriptase	31,63	c-myc	telomerase reverse transcriptase	4609	7015	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcript regulation of human telomerase_reverse_transcriptase by c-myc and mad1 .
2064352	0	c-myc	21,26	transferrin	28,39	c-myc	transferrin	4609	7018	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Coordinate change of c-myc , transferrin receptor and H3 gene expression precedes induction of haemoglobin-producing cells of the leukaemia K562 cell line treated with cis-diamminedichloroplatinum _ -LRB- II -RRB- .
2161812	0	c-myc	14,19	transforming_growth_factor_beta_1	34,67	c-myc	transforming growth factor beta 1	4609	7040	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression Modulation|nmod|END_ENTITY	Modulation of c-myc expression by transforming_growth_factor_beta_1 in human hepatoma cell lines .
3474039	0	c-myc	56,61	tumor_necrosis_factor_alpha	18,45	c-myc	tumor necrosis factor alpha	4609	7124	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Recombinant human tumor_necrosis_factor_alpha regulates c-myc expression in HL-60 cells at the level of transcription .
8524218	0	c-myc	16,21	v-Abl	0,5	c-myc	v-Abl	4609	25	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	v-Abl activates c-myc transcription through the E2F site .
9119380	0	c-myc_promoter-binding_protein	52,82	MPB1	84,88	c-myc promoter-binding protein	MPB1	10260	2023	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Chromosomal localization of the human gene encoding c-myc_promoter-binding_protein -LRB- MPB1 -RRB- to chromosome 1p35-pter .
1658623	0	c-rasH	127,133	p21	80,83	c-rasH	p21	80150	644914	Gene	Gene	amino_acids|nmod|START_ENTITY amino_acids|nsubj|identification identification|nmod|END_ENTITY	The bovine papillomavirus E5 oncogene can cooperate with ras : identification of p21 amino_acids critical for transformation by c-rasH but not v-rasH .
6092927	0	c-rasH	28,34	p21	35,38	c-rasH	p21	80150	644914	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Metabolic turnover of human c-rasH p21 protein of EJ bladder_carcinoma and its normal cellular and viral homologs .
21325823	0	c-reactive_protein	41,59	Angiotensin_II	0,14	c-reactive protein	Angiotensin II	1401	183	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces the expression of c-reactive_protein via MAPK-dependent signal pathway in U937 macrophages .
16352190	0	c-reactive_protein	73,91	nuclear_factor-kappaB	14,35	c-reactive protein	nuclear factor-kappaB	1401	4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of nuclear_factor-kappaB and correlation with elevated plasma c-reactive_protein in patients with unstable_angina .
24554512	0	c-reactive_protein	86,104	vascular_cell_adhesion_molecule-1	132,165	c-reactive protein	vascular cell adhesion molecule-1	1401	7412	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effects of metformin or an oral contraceptive containing cyproterone_acetate on serum c-reactive_protein , interleukin-6 and soluble vascular_cell_adhesion_molecule-1 concentrations in women with polycystic_ovary_syndrome .
17617603	0	c-rel	84,89	CD28	101,105	c-rel	CD28	5966	940	Gene	Gene	START_ENTITY|nmod|activation activation|nummod|END_ENTITY	TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation .
7935451	0	c-rel	169,174	I_kappa_B_alpha	112,127	c-rel	I kappa B alpha	5966	4792	Gene	Gene	gene|amod|START_ENTITY induction|nmod|gene mediated|dobj|induction mediated|parataxis|involves involves|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
7935451	0	c-rel	169,174	NF-kappa_B	53,63	c-rel	NF-kappa B	5966	4790	Gene	Gene	gene|amod|START_ENTITY induction|nmod|gene mediated|dobj|induction mediated|nsubj|activation activation|nmod|END_ENTITY	Human T-cell_leukemia_virus_type_I Tax activation of NF-kappa_B / Rel involves phosphorylation and degradation of I_kappa_B_alpha and RelA -LRB- p65 -RRB- - mediated induction of the c-rel gene .
11672537	0	c-rel	25,30	Spi-B	5,10	c-rel	Spi-B	19696(Tax:10090)	272382(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	PU .1 / Spi-B regulation of c-rel is essential for mature B cell survival .
8510222	0	c-rel	130,135	Tax	139,142	c-rel	Tax	5966	1491938(Tax:11908)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Differential expression of Rel family members in human T-cell_leukemia_virus_type_I-infected cells : transcriptional activation of c-rel by Tax protein .
1623561	0	c-sis	24,29	Interleukin_6	0,13	c-sis	Interleukin 6	5155	3569	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Interleukin_6 modulates c-sis gene expression in cultured human endothelial cells .
2696512	0	c-sis	32,37	PDGF-B	24,30	c-sis	PDGF-B	24628(Tax:10116)	24628(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Increased expression of PDGF-B -LRB- c-sis -RRB- mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hyperoxia .
2660925	0	c-sis	43,48	PDGFB	36,41	c-sis	PDGFB	5155	5155	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Translocation of c-abl oncogene and PDGFB -LRB- c-sis -RRB- gene in a case of CML with 46 , XY , t -LRB- 22 ; 22 -RRB- .
2067847	0	c-sis	77,82	PDGF_B	70,76	c-sis	PDGF B	5155	5155	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	5 ' untranslated sequences determine degradative pathway for alternate PDGF_B / c-sis mRNA 's .
2426251	0	c-sis	20,25	Thrombin	0,8	c-sis	Thrombin	5155	2147	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Thrombin stimulates c-sis gene expression in microvascular endothelial cells .
11596289	0	c-sis	159,164	c-myc	166,171	c-sis	c-myc	24628(Tax:10116)	24577(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of 1 - -LRB- 2,6-dimethylphenoxy -RRB- -2 - -LRB- 3,4-dimethoxyphenylethylamino -RRB- _ propane_hydrochloride on proliferation of vascular smooth muscle cells and PDGF-B , bFGF , c-sis , c-myc in spontaneously hypertensive rat -RSB- .
8621696	0	c-sis	99,104	platelet-derived_growth_factor_B-chain	59,97	c-sis	platelet-derived growth factor B-chain	5155	5155	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Identification of a thrombin response element in the human platelet-derived_growth_factor_B-chain -LRB- c-sis -RRB- promoter .
10938893	0	c-sis	68,73	platelet-derived_growth_factor_B_chain	28,66	c-sis	platelet-derived growth factor B chain	5155	5155	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Translational regulation of platelet-derived_growth_factor_B_chain -LRB- c-sis -RRB- mRNA by short open reading frames in the 5 ' - untranslated region .
3040721	0	c-sis	57,62	thrombin	76,84	c-sis	thrombin	5155	2147	Gene	Gene	block|dobj|START_ENTITY Agents|dep|block induction|nsubj|Agents induction|nmod|END_ENTITY	Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta .
8621696	0	c-sis	99,104	thrombin	20,28	c-sis	thrombin	5155	2147	Gene	Gene	promoter|appos|START_ENTITY Identification|nmod|promoter Identification|nmod|element element|compound|END_ENTITY	Identification of a thrombin response element in the human platelet-derived_growth_factor_B-chain -LRB- c-sis -RRB- promoter .
9371722	0	c-ski	59,64	myogenin	20,28	c-ski	myogenin	20481(Tax:10090)	17928(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation : the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubes .
14707140	0	c-src	112,117	diacylglycerol_kinase-zeta	53,79	c-src	diacylglycerol kinase-zeta	6714	8525	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Gonadotropin-releasing_hormone-induced activation of diacylglycerol_kinase-zeta and its association with active c-src .
8845374	0	c-src	95,100	epidermal_growth_factor_receptor	32,64	c-src	epidermal growth factor receptor	6714	1956	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	In vitro phosphorylation of the epidermal_growth_factor_receptor autophosphorylation domain by c-src : identification of phosphorylation sites and c-src SH2 domain binding sites .
9157979	0	c-src	56,61	p60	52,55	c-src	p60	6714	8878	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	Potent pseudosubstrate-based peptide inhibitors for p60 -LRB- c-src -RRB- protein tyrosine kinase .
8742077	0	c-src	81,86	protein_tyrosine_kinase	45,68	c-src	protein tyrosine kinase	6714	2046	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	A solid-phase assay for the determination of protein_tyrosine_kinase activity of c-src using scintillating microtitration plates .
9422768	0	c-src	152,157	vascular_endothelial_growth_factor	19,53	c-src	vascular endothelial growth factor	6714	7422	Gene	Gene	transfected|advcl|START_ENTITY transfected|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of vascular_endothelial_growth_factor in a human colon_carcinoma cell line transfected with an antisense expression vector specific for c-src .
8584023	0	c-src_kinase	38,50	Prolactin_receptor	0,18	c-src kinase	Prolactin receptor	315707(Tax:10116)	24684(Tax:10116)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Prolactin_receptor is associated with c-src_kinase in rat liver .
1377109	0	c-src_tyrosine_kinase	4,25	CSK	27,30	c-src tyrosine kinase	CSK	1445	1445	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The c-src_tyrosine_kinase -LRB- CSK -RRB- gene , a potential antioncogene , localizes to human chromosome region 15q23 -- q25 .
24745549	0	c-type_lysozyme	35,50	LYZL6	14,19	c-type lysozyme	LYZL6	4069	57151	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of LYZL6 , a novel human c-type_lysozyme , in recombinant Pichia_pastoris employing high cell density fed-batch fermentation .
22473608	0	c1q	60,63	calreticulin	35,47	c1q	calreticulin	712	811	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Entamoeba_histolytica cell surface calreticulin binds human c1q and functions in amebic phagocytosis of host cells .
24557008	0	c1q	25,28	calreticulin	56,68	c1q	calreticulin	712	811	Gene	Gene	cell-surface|amod|START_ENTITY contribution|nmod|cell-surface END_ENTITY|nsubj|contribution	Relative contribution of c1q and apoptotic cell-surface calreticulin to macrophage phagocytosis .
14629629	0	c4b-binding_protein	83,102	factor_h	63,71	c4b-binding protein	factor h	722	3075	Gene	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Ontogeny of complement regulatory proteins - concentrations of factor_h , factor I , c4b-binding_protein , properdin and vitronectin in healthy children of different ages and in adults .
26744410	0	c8orf4	60,66	Cyclooxygenase-2	25,41	c8orf4	Cyclooxygenase-2	56892	5743	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Epigenetic Regulation of Cyclooxygenase-2 by methylation of c8orf4 in Pulmonary Fibrosis .
7640345	0	cA2	44,47	TNF-alpha	80,89	cA2	TNF-alpha	760	7124	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Chimeric anti-TNF-alpha monoclonal antibody cA2 binds recombinant transmembrane TNF-alpha and activates immune effector functions .
2364283	0	cAAT	60,64	cytosolic_aspartate_aminotransferase	22,58	cAAT	cytosolic aspartate aminotransferase	24401(Tax:10116)	24401(Tax:10116)	Gene	Gene	Immunolocalization|appos|START_ENTITY Immunolocalization|nmod|END_ENTITY	Immunolocalization of cytosolic_aspartate_aminotransferase -LRB- cAAT -RRB- in axon terminals that form synapses in the rat cerebellar cortex .
11532906	0	cAMP	34,38	Glucagon-like_peptide-1	0,23	cAMP	Glucagon-like peptide-1	316010(Tax:10116)	24952(Tax:10116)	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Glucagon-like_peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes .
23197717	0	cAMP	47,51	Rac1	0,4	cAMP	Rac1	12796(Tax:10090)	19353(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Rac1 controls Schwann cell myelination through cAMP and NF2/merlin .
2174893	0	cAMP	39,43	c-jun	14,19	cAMP	c-jun	820	3725	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of c-jun gene expression by cAMP in HL-60 myeloid_leukemia cells .
11056535	0	cAMP	33,37	cAMP-GEFII	0,10	cAMP	cAMP-GEFII	820	11069	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	cAMP-GEFII is a direct target of cAMP in regulated exocytosis .
11056535	0	cAMP-GEFII	0,10	cAMP	33,37	cAMP-GEFII	cAMP	11069	820	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	cAMP-GEFII is a direct target of cAMP in regulated exocytosis .
12920200	0	cAMP-dependent_protein_kinase	128,157	protein_tyrosine_phosphatase	94,122	cAMP-dependent protein kinase	protein tyrosine phosphatase	171150(Tax:10116)	24697(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Adenosine-A2a_receptor down-regulates cerebral smooth muscle L-type Ca2 + channel activity via protein_tyrosine_phosphatase , not cAMP-dependent_protein_kinase .
2869031	0	cAMP-dependent_vasoactive_intestinal_peptide	65,109	prolactin	172,181	cAMP-dependent vasoactive intestinal peptide	prolactin	117064(Tax:10116)	24683(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent_vasoactive_intestinal_peptide and cAMP-independent thyrotropin_releasing_hormone-stimulated prolactin secretion of GH3 cells .
11988078	0	cAMP-response-element-binding_protein	46,83	CREB	85,89	cAMP-response-element-binding protein	CREB	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	A novel pathway for adrenergic stimulation of cAMP-response-element-binding_protein -LRB- CREB -RRB- phosphorylation : mediation via alpha1-adrenoceptors and protein kinase C activation .
15285719	0	cAMP-response-element-binding_protein	38,75	NALP1	0,5	cAMP-response-element-binding protein	NALP1	1385	22861	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	NALP1 is a transcriptional target for cAMP-response-element-binding_protein -LRB- CREB -RRB- in myeloid_leukaemia cells .
12368293	0	cAMP-response_element-binding_protein	94,131	CREB	133,137	cAMP-response element-binding protein	CREB	1385	1385	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Nitric_oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response_element-binding_protein -LRB- CREB -RRB- activation .
12743114	0	cAMP-response_element-binding_protein	82,119	CREB	121,125	cAMP-response element-binding protein	CREB	1385	1385	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Tissue_transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response_element-binding_protein -LRB- CREB -RRB- activation .
18694792	0	cAMP-response_element-binding_protein	103,140	CREB	97,101	cAMP-response element-binding protein	CREB	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	pathway|appos|START_ENTITY pathway|compound|END_ENTITY	NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein_kinase_A and CREB -LRB- cAMP-response_element-binding_protein -RRB- pathway .
15689617	0	cAMP-response_element-binding_protein	0,37	Huntingtin	114,124	cAMP-response element-binding protein	Huntingtin	81646(Tax:10116)	29424(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	cAMP-response_element-binding_protein contributes to suppression of the A2A_adenosine_receptor promoter by mutant Huntingtin with expanded polyglutamine residues .
10585438	0	cAMP-response_element-binding_protein	18,55	NF-kappaB	0,9	cAMP-response element-binding protein	NF-kappaB	12912(Tax:10090)	18033(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	NF-kappaB induces cAMP-response_element-binding_protein gene transcription in sertoli cells .
11116137	0	cAMP-response_element-binding_protein	10,47	presenilin-1	81,93	cAMP-response element-binding protein	presenilin-1	1385	5663	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Activated cAMP-response_element-binding_protein regulates neuronal expression of presenilin-1 .
23526216	0	cAMP-response_element_binding_protein_1	50,89	interleukin_8	116,129	cAMP-response element binding protein 1	interleukin 8	1385	3576	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Role of hypoxia-inducible factor 1 , a subunit and cAMP-response_element_binding_protein_1 in synergistic release of interleukin_8 by prostaglandin_E2 and nickel in lung fibroblasts .
10406459	0	cAMP-responsive_element-binding_protein	139,178	CREB	133,137	cAMP-responsive element-binding protein	CREB	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	A dominant role for the Raf-MEK pathway in forskolin , 12-O-tetradecanoyl-phorbol_acetate , and platelet-derived growth factor-induced CREB -LRB- cAMP-responsive_element-binding_protein -RRB- activation , uncoupled from serine 133 phosphorylation in NIH 3T3 cells .
16873684	0	cAMP-responsive_element-binding_protein	52,91	ERK1/2	0,6	cAMP-responsive element-binding protein	ERK1/2	81646(Tax:10116)	50689;116590	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	ERK1/2 control phosphorylation and protein level of cAMP-responsive_element-binding_protein : a key role in glucose-mediated pancreatic beta-cell survival .
14684741	0	cAMP-responsive_element-binding_protein	23,62	LIM_kinase_1	0,12	cAMP-responsive element-binding protein	LIM kinase 1	1385	3984	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	LIM_kinase_1 activates cAMP-responsive_element-binding_protein during the neuronal differentiation of immortalized hippocampal progenitor cells .
9668114	0	cAMP-responsive_element-binding_protein	73,112	Tax	60,63	cAMP-responsive element-binding protein	Tax	1385	6900	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	The human T-cell_leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive_element-binding_protein -LRB- CREB -RRB- binding activity through interactions with the DNA minor groove .
18957421	0	cAMP-responsive_element-binding_protein	54,93	cyclin_D1	14,23	cAMP-responsive element-binding protein	cyclin D1	1385	595	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of cyclin_D1 and Wnt10b gene expression by cAMP-responsive_element-binding_protein during early adipogenesis involves differential promoter methylation .
14523007	0	cAMP-responsive_element-binding_protein	91,130	heme_oxygenase-1	50,66	cAMP-responsive element-binding protein	heme oxygenase-1	1385	3162	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Oxidized phospholipids induce expression of human heme_oxygenase-1 involving activation of cAMP-responsive_element-binding_protein .
10567368	0	cAMP-responsive_element-binding_protein	79,118	transforming_growth_factor-beta2	34,66	cAMP-responsive element-binding protein	transforming growth factor-beta2	1385	7042	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Transcriptional regulation of the transforming_growth_factor-beta2 promoter by cAMP-responsive_element-binding_protein -LRB- CREB -RRB- and activating_transcription_factor-1 -LRB- ATF-1 -RRB- is modulated by protein kinases and the coactivators p300 and CREB-binding_protein .
15725648	0	cAMP-responsive_element_modulator	51,84	CREM	86,90	cAMP-responsive element modulator	CREM	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	The administration of retinoic_acid down-regulates cAMP-responsive_element_modulator -LRB- CREM -RRB- mRNA in vitamin_A-deficient testes .
17889470	0	cAMP-responsive_element_modulator	50,83	CREM	85,89	cAMP-responsive element modulator	CREM	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of Rubus coreanus on sperm parameters and cAMP-responsive_element_modulator -LRB- CREM -RRB- expression in rat testes .
18374528	0	cAMP-responsive_element_modulator	39,72	CREM	74,78	cAMP-responsive element modulator	CREM	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of Psoralea corylifolia on the cAMP-responsive_element_modulator -LRB- CREM -RRB- expression and spermatogenesis in rats .
22025620	0	cAMP-responsive_element_modulator	0,33	CREM	35,39	cAMP-responsive element modulator	CREM	1390	1390	Gene	Gene	induces|nsubj|START_ENTITY induces|dep|END_ENTITY	cAMP-responsive_element_modulator -LRB- CREM -RRB- a protein induces interleukin_17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic_lupus_erythematosus .
21883931	0	cAMP-responsive_element_modulator	98,131	Cyp17a1	160,167	cAMP-responsive element modulator	Cyp17a1	12916(Tax:10090)	13074(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal gland -- involvement of cAMP-responsive_element_modulator in epigenetic regulation of Cyp17a1 .
1647033	0	cAMP-responsive_element_modulator	27,60	c-fos	83,88	cAMP-responsive element modulator	c-fos	1390	2353	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	Transcriptional antagonist cAMP-responsive_element_modulator -LRB- CREM -RRB- down-regulates c-fos cAMP-induced expression .
22025620	0	cAMP-responsive_element_modulator	0,33	interleukin_17A	58,73	cAMP-responsive element modulator	interleukin 17A	1390	3605	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	cAMP-responsive_element_modulator -LRB- CREM -RRB- a protein induces interleukin_17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic_lupus_erythematosus .
10551787	0	cAMP-responsive_element_modulator	43,76	lanosterol_14alpha-demethylase	124,154	cAMP-responsive element modulator	lanosterol 14alpha-demethylase	12916(Tax:10090)	13121(Tax:10090)	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Cyclic adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- / cAMP-responsive_element_modulator -LRB- CREM -RRB- - dependent regulation of cholesterogenic lanosterol_14alpha-demethylase -LRB- CYP51 -RRB- in spermatids .
15212707	0	cAMP/PKA/CREB	20,33	IFN-gamma	0,9	cAMP/PKA/CREB	IFN-gamma	12796;12912	15978(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	IFN-gamma activates cAMP/PKA/CREB signaling pathway in murine peritoneal macrophages .
1327124	0	cAMP_receptor_protein	28,49	CRP	51,54	cAMP receptor protein	CRP	20468888	20468888	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Transcription activation by cAMP_receptor_protein -LRB- CRP -RRB- at the Escherichia_coli gal P1 promoter .
1331087	0	cAMP_regulatory_element_binding	72,103	CREB	113,117	cAMP regulatory element binding	CREB	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Beta-adrenergic stimulation of cFOS via protein kinase A is mediated by cAMP_regulatory_element_binding protein -LRB- CREB -RRB- - dependent and tissue-specific CREB-independent mechanisms in corticotrope cells .
12790807	0	cAMP_response-element_binding_protein	91,128	steroidogenic_acute_regulatory	40,70	cAMP response-element binding protein	steroidogenic acute regulatory	12912(Tax:10090)	20845(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY END_ENTITY|nmod|factor	Transcriptional regulation of the mouse steroidogenic_acute_regulatory protein gene by the cAMP_response-element_binding_protein and steroidogenic factor 1 .
10804193	0	cAMP_response_element-binding_protein	71,108	CREB	110,114	cAMP response element-binding protein	CREB	1385	1385	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|appos|END_ENTITY	Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP_response_element-binding_protein -LRB- CREB -RRB- in hippocampal neurons .
12540838	0	cAMP_response_element-binding_protein	52,89	CREB	91,95	cAMP response element-binding protein	CREB	1385	1385	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Persistent ERK phosphorylation negatively regulates cAMP_response_element-binding_protein -LRB- CREB -RRB- activity via recruitment of CREB-binding_protein to pp90RSK .
17127423	0	cAMP_response_element-binding_protein	33,70	CREB	72,76	cAMP response element-binding protein	CREB	1385	1385	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Multisite phosphorylation of the cAMP_response_element-binding_protein -LRB- CREB -RRB- by a diversity of protein kinases .
23990467	0	cAMP_response_element-binding_protein	129,166	CREB	168,172	cAMP response element-binding protein	CREB	1385	1385	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species -LRB- ROS -RRB- levels and cAMP_response_element-binding_protein -LRB- CREB -RRB- activation .
11518709	0	cAMP_response_element-binding_protein	31,68	Dyrk1	15,20	cAMP response element-binding protein	Dyrk1	1385	1859	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Protein kinase Dyrk1 activates cAMP_response_element-binding_protein during neuronal differentiation in hippocampal progenitor cells .
12540838	0	cAMP_response_element-binding_protein	52,89	ERK	11,14	cAMP response element-binding protein	ERK	1385	5594	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Persistent ERK phosphorylation negatively regulates cAMP_response_element-binding_protein -LRB- CREB -RRB- activity via recruitment of CREB-binding_protein to pp90RSK .
10490957	0	cAMP_response_element-binding_protein	124,161	IL-6	86,90	cAMP response element-binding protein	IL-6	81646(Tax:10116)	24498(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	MHC class II engagement in brain endothelial cells induces protein kinase A-dependent IL-6 secretion and phosphorylation of cAMP_response_element-binding_protein .
7836756	0	cAMP_response_element-binding_protein	48,85	Protein_kinase_C	0,16	cAMP response element-binding protein	Protein kinase C	81646(Tax:10116)	24681(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Protein_kinase_C mediates activation of nuclear cAMP_response_element-binding_protein -LRB- CREB -RRB- in B lymphocytes stimulated through surface Ig .
18378685	0	cAMP_response_element-binding_protein	47,84	Protein_kinase_D	0,16	cAMP response element-binding protein	Protein kinase D	12912(Tax:10090)	18760(Tax:10090)	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	Protein_kinase_D links Gq-coupled receptors to cAMP_response_element-binding_protein -LRB- CREB -RRB- - Ser133 phosphorylation in the heart .
15523052	0	cAMP_response_element-binding_protein	38,75	Steroidogenic_factor-1	0,22	cAMP response element-binding protein	Steroidogenic factor-1	1385	2516	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Steroidogenic_factor-1 interacts with cAMP_response_element-binding_protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer .
14607516	0	cAMP_response_element-binding_protein	40,77	p38	18,21	cAMP response element-binding protein	p38	1385	1432	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Downregulation of p38 kinase pathway by cAMP_response_element-binding_protein protects HL-60 cells from iron chelator-induced apoptosis .
21890628	0	cAMP_response_element-binding_protein	59,96	regulator_of_calcineurin_1	4,30	cAMP response element-binding protein	regulator of calcineurin 1	1385	1827	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The regulator_of_calcineurin_1 -LRB- RCAN1/DSCR1 -RRB- activates the cAMP_response_element-binding_protein -LRB- CREB -RRB- pathway .
8702497	0	cAMP_response_element-binding_protein-1	114,153	DNA_polymerase_beta	24,43	cAMP response element-binding protein-1	DNA polymerase beta	1385	5423	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|promoter promoter|compound|END_ENTITY	Activation of the human DNA_polymerase_beta promoter by a DNA-alkylating agent through induced phosphorylation of cAMP_response_element-binding_protein-1 .
12435435	0	cAMP_response_element_binding	19,48	CREB	50,54	cAMP response element binding	CREB	1385	1385	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Phosphorylation of cAMP_response_element_binding -LRB- CREB -RRB- protein during hypoxia in cerebral cortex of newborn piglets and the effect of nitric_oxide_synthase inhibition .
16598418	0	cAMP_response_element_binding_protein	19,56	CREB	58,62	cAMP response element binding protein	CREB	1385	1385	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of cAMP_response_element_binding_protein -LRB- CREB -RRB- as a marker of hypoxia in pituitary_adenoma .
9030696	0	cAMP_response_element_binding_protein	14,51	CREB	53,57	cAMP response element binding protein	CREB	1385	1385	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of cAMP_response_element_binding_protein -LRB- CREB -RRB- binding in the mammalian clock pacemaker by light but not a circadian clock .
21784978	0	cAMP_response_element_binding_protein	13,50	inositol_trisphosphate_receptor	110,141	cAMP response element binding protein	inositol trisphosphate receptor	12912(Tax:10090)	16438(Tax:10090)	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Constitutive cAMP_response_element_binding_protein -LRB- CREB -RRB- activation by Alzheimer 's _ disease presenilin-driven inositol_trisphosphate_receptor -LRB- InsP3R -RRB- Ca2 + signaling .
24064350	0	cAMP_response_element_binding_protein	4,41	insulin-like_growth_factor-1	65,93	cAMP response element binding protein	insulin-like growth factor-1	1385	3479	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	The cAMP_response_element_binding_protein -LRB- CREB -RRB- is activated by insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and regulates myostatin gene expression in skeletal myoblast .
21757709	0	cAMP_response_element_modulator	17,48	AP-1	102,106	cAMP response element modulator	AP-1	1390	2353	Gene	Gene	promoter|compound|START_ENTITY regulated|nsubjpass|promoter regulated|nmod|END_ENTITY	A novel intronic cAMP_response_element_modulator -LRB- CREM -RRB- promoter is regulated by activator_protein-1 -LRB- AP-1 -RRB- and accounts for altered activation-induced CREM expression in T cells from patients with systemic_lupus_erythematosus .
15804863	0	cAMP_response_element_modulator	35,66	CREM	68,72	cAMP response element modulator	CREM	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased testicular expression of cAMP_response_element_modulator -LRB- CREM -RRB- in rat with varicocele .
10728443	0	cAMP_responsive_element_binding_protein	15,54	CREB	56,60	cAMP responsive element binding protein	CREB	1385	1385	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of cAMP_responsive_element_binding_protein -LRB- CREB -RRB- in the synovial cell hyperfunction in patients with rheumatoid_arthritis .
1387109	0	cAMP_responsive_element_binding_protein	16,55	CREB	10,14	cAMP responsive element binding protein	CREB	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse CREB -LRB- cAMP_responsive_element_binding_protein -RRB- gene : structure , promoter analysis , and chromosomal localization .
26692949	0	cAMP_responsive_element_binding_protein_1	79,120	MicroRNA-205	0,12	cAMP responsive element binding protein 1	MicroRNA-205	1385	406988	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	MicroRNA-205 functions as a tumor suppressor in colorectal_cancer by targeting cAMP_responsive_element_binding_protein_1 -LRB- CREB1 -RRB- .
20876284	0	cFLIP	30,35	ATM	0,3	cFLIP	ATM	8837	472	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	ATM kinase activity modulates cFLIP protein levels : potential interplay between DNA damage signalling and TRAIL-induced apoptosis .
16167063	0	cFLIP	151,156	CAR	114,117	cFLIP	CAR	8837	1525	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	In vitro efficacy of AdTRAIL gene therapy of bladder_cancer is enhanced by trichostatin_A-mediated restoration of CAR expression and downregulation of cFLIP and Bcl-XL .
15025952	0	cFLIP	50,55	cellular_FLICE_inhibitory_protein	15,48	cFLIP	cellular FLICE inhibitory protein	8837	8837	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of cellular_FLICE_inhibitory_protein -LRB- cFLIP -RRB- in endometrial_adenocarcinoma -RSB- .
11313989	0	cFLIP	16,21	p53	0,3	cFLIP	p53	8837	7157	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	p53 upregulates cFLIP , inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells .
12746452	0	cFLIP-L	0,7	p38	17,20	cFLIP-L	p38	8837	1432	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	cFLIP-L inhibits p38 MAPK activation : an additional anti-apoptotic mechanism in bile_acid-mediated apoptosis .
11493024	0	cFOS	36,40	Tumor_necrosis_factor-alpha	0,27	cFOS	Tumor necrosis factor-alpha	314322(Tax:10116)	24835(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord .
9045998	0	cFos	69,73	LHRH	64,68	cFos	LHRH	314322(Tax:10116)	25194(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Alpha1-adrenergic receptor blockade blocks LH secretion but not LHRH cFos activation .
20057151	0	cGK-II	64,70	cGMP-dependent_protein_kinase_II	30,62	cGK-II	cGMP-dependent protein kinase II	19092(Tax:10090)	19092(Tax:10090)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of cGMP-dependent_protein_kinase_II -LRB- cGK-II -RRB- in chondrocytes .
10769052	0	cGMP-binding_cGMP-specific_phosphodiesterase	36,80	PDE5	82,86	cGMP-binding cGMP-specific phosphodiesterase	PDE5	171115(Tax:10116)	8654	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of cGMP-binding_cGMP-specific_phosphodiesterase -LRB- PDE5 -RRB- in rat tissues .
9445376	0	cGMP-binding_cGMP-specific_phosphodiesterase	44,88	PDE5	90,94	cGMP-binding cGMP-specific phosphodiesterase	PDE5	8654	8654	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of cGMP to both allosteric sites of cGMP-binding_cGMP-specific_phosphodiesterase -LRB- PDE5 -RRB- is required for its phosphorylation .
25586176	0	cGMP-dependent_Kinase	82,103	GKAP42	52,58	cGMP-dependent Kinase	GKAP42	5592	80318	Gene	Gene	Levels|nmod|START_ENTITY Levels|compound|END_ENTITY	Tumor Necrosis Factor -LRB- TNF -RRB- - a-induced Repression of GKAP42 Protein Levels through cGMP-dependent_Kinase -LRB- cGK -RRB- - Ia Causes Insulin Resistance in 3T3-L1 Adipocytes .
9675253	0	cGMP-dependent_protein_kinase	34,63	Src	67,70	cGMP-dependent protein kinase	Src	5592	6714	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of cGMP-dependent_protein_kinase by Src .
20057151	0	cGMP-dependent_protein_kinase_II	30,62	cGK-II	64,70	cGMP-dependent protein kinase II	cGK-II	19092(Tax:10090)	19092(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of cGMP-dependent_protein_kinase_II -LRB- cGK-II -RRB- in chondrocytes .
15789223	0	cGPx	56,60	cytosolic_glutathione_peroxidase	22,54	cGPx	cytosolic glutathione peroxidase	14775(Tax:10090)	14775(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression pattern of cytosolic_glutathione_peroxidase -LRB- cGPx -RRB- mRNA during mouse embryogenesis .
19397698	0	cIAP-1	143,149	Kip1	164,168	cIAP-1	Kip1	329	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Human_papillomavirus_16 E6/E7-immortalized human gingival keratinocytes with epithelial mesenchymal transition acquire increased expression of cIAP-1 , Bclx and p27 -LRB- Kip1 -RRB- .
14527959	0	cIAP-2	13,19	NF-kappa_B	66,76	cIAP-2	NF-kappa B	330	4790	Gene	Gene	Induction|nmod|START_ENTITY Induction|parataxis|END_ENTITY	Induction of cIAP-2 in human colon_cancer cells through PKC_delta / NF-kappa_B .
14527959	0	cIAP-2	13,19	PKC_delta	56,65	cIAP-2	PKC delta	330	5580	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cIAP-2 in human colon_cancer cells through PKC_delta / NF-kappa_B .
24276241	0	cIAP1	0,5	cdc42	29,34	cIAP1	cdc42	329	998	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation .
22403404	0	cIAP1/2	99,106	Bcl-xL	32,38	cIAP1/2	Bcl-xL	329;330	598	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role for antiapoptotic Bcl-xL and Mcl-1 in human macrophage survival and cellular IAP1/2 -LRB- cIAP1/2 -RRB- in resistance to HIV-Vpr-induced apoptosis .
12393423	0	cIAP2	101,106	cIAP2	170,175	cIAP2	cIAP2	330	330	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Expression of the inhibitor of apoptosis -LRB- IAP -RRB- family members in human neutrophils : up-regulation of cIAP2 by granulocyte_colony-stimulating_factor and overexpression of cIAP2 in chronic neutrophilic_leukemia .
12393423	0	cIAP2	170,175	cIAP2	101,106	cIAP2	cIAP2	330	330	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Expression of the inhibitor of apoptosis -LRB- IAP -RRB- family members in human neutrophils : up-regulation of cIAP2 by granulocyte_colony-stimulating_factor and overexpression of cIAP2 in chronic neutrophilic_leukemia .
25501826	0	cIAP2	38,43	caspase-3	14,23	cIAP2	caspase-3	330	836	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia .
17989734	0	cIAP2	155,160	caspase-8	119,128	cIAP2	caspase-8	330	841	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2 .
10942386	0	cJun	4,8	JNK	28,31	cJun	JNK	16476(Tax:10090)	26419(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	The cJun N-terminal kinase -LRB- JNK -RRB- signaling pathway mediates induction of urokinase-type_plasminogen_activator -LRB- uPA -RRB- by the alkylating agent MNNG .
19859790	0	cJun	92,96	c-Jun-NH2_terminal_kinase	0,25	cJun	c-Jun-NH2 terminal kinase	3725	5599	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	c-Jun-NH2_terminal_kinase -LRB- JNK -RRB- - mediates AP-1 activation by thioredoxin : phosphorylation of cJun , JunB , and Fra-1 .
19767119	0	cJun-N-terminal_kinase_1_and_2	20,50	retinoid_X_receptor_alpha	134,159	cJun-N-terminal kinase 1 and 2	retinoid X receptor alpha	26419;26420	20181(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Redundant roles for cJun-N-terminal_kinase_1_and_2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid_X_receptor_alpha .
18602973	0	cKrox	64,69	CD4	152,155	cKrox	CD4	51043	920	Gene	Gene	expression|nmod|START_ENTITY expression|appos|factors factors|acl|controlling controlling|dobj|commitment commitment|nmod|+ +|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
17296789	0	cKrox	39,44	CD8	59,62	cKrox	CD8	51043	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation .
18602973	0	cKrox	64,69	CD8	156,159	cKrox	CD8	51043	925	Gene	Gene	expression|nmod|START_ENTITY expression|appos|factors factors|acl|controlling controlling|dobj|commitment commitment|nmod|+ +|compound|END_ENTITY	2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3 , transcription regulatory factors controlling the lineage commitment of CD4 + CD8 + into CD4 and CD8 thymocytes , respectively .
23272972	0	cMET	30,34	FAK	51,54	cMET	FAK	4233	5747	Gene	Gene	interaction|nmod|START_ENTITY Inhibiting|dobj|interaction Inhibiting|nmod|END_ENTITY	Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic_cancer cells in vitro and in vivo .
25090459	0	cMET	10,14	PI3K	32,36	cMET	PI3K	4233	5293	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Activated cMET and IGF1R-driven PI3K signaling predicts poor survival in colorectal_cancers independent of KRAS mutational status .
10496535	0	cMOAT	118,123	PDZK1	0,5	cMOAT	PDZK1	1244	5174	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PDZK1 , a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21 , interacts with cMOAT -LRB- MRP2 -RRB- , the multidrug_resistance-associated_protein .
10590227	0	cMOAT	80,85	canalicular_multispecific_organic_anion_transporter	27,78	cMOAT	canalicular multispecific organic anion transporter	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of canalicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver .
8797578	0	cMOAT	61,66	canalicular_multispecific_organic_anion_transporter	8,59	cMOAT	canalicular multispecific organic anion transporter	1244	1244	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A human canalicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased_drug_accumulation .
9556204	0	cMOAT	111,116	canalicular_multispecific_organic_anion_transporter	58,109	cMOAT	canalicular multispecific organic anion transporter	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Differential expression of multidrug resistance -LRB- mdr -RRB- and canalicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- genes following extrahepatic biliary_obstruction in rats .
9425227	0	cMOAT	70,75	canilicular_multispecific_organic_anion_transporter	17,68	cMOAT	canilicular multispecific organic anion transporter	1244	1244	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in the canilicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- gene , a novel ABC transporter , in patients with hyperbilirubinemia II/Dubin-Johnson _ syndrome .
17214965	0	cMet	81,85	HGF	38,41	cMet	HGF	100126565(Tax:9986)	100316908(Tax:9986)	Gene	Gene	interaction|nmod|START_ENTITY induced|nmod|interaction induced|nmod|END_ENTITY	A neutralizable epitope is induced on HGF upon its interaction with its receptor cMet .
23942518	0	cMyb	21,25	Pax7	0,4	cMyb	Pax7	396244(Tax:9031)	395942(Tax:9031)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Pax7 is regulated by cMyb during early neural crest development through a novel enhancer .
25425964	0	cMyc	83,87	PCAT-1	24,30	cMyc	PCAT-1	4609	100750225	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	The long non-coding RNA PCAT-1 promotes prostate_cancer cell proliferation through cMyc .
9698766	0	cNOS	36,40	Constitutive_nitric_oxide_synthase	0,34	cNOS	Constitutive nitric oxide synthase	24600(Tax:10116)	24600(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Constitutive_nitric_oxide_synthase -LRB- cNOS -RRB- activity in Langerhans islets from streptozotocin diabetic rats .
16806120	0	cPGES	37,42	Cytosolic_prostaglandin_E2_synthase	0,35	cPGES	Cytosolic prostaglandin E2 synthase	10728	10728	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cytosolic_prostaglandin_E2_synthase -LRB- cPGES -RRB- expression is decreased in discrete cortical regions in psychiatric_disease .
12101222	0	cPLA2	28,33	Cytosolic_phospholipase_A2	0,26	cPLA2	Cytosolic phospholipase A2	5321	5321	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	Cytosolic_phospholipase_A2 -LRB- cPLA2 -RRB- regulation of human monocyte NADPH oxidase activity .
10521702	0	cPLA2	40,45	IL-13	0,5	cPLA2	IL-13	18783(Tax:10090)	16163(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-13 induces serine phosphorylation of cPLA2 in mouse peritoneal macrophages leading to arachidonic_acid and PGE2 production and blocks the zymosan-induced serine phosphorylation of cPLA2 and eicosanoid production .
9748607	0	cPLA2	20,25	IL-13	0,5	cPLA2	IL-13	18783(Tax:10090)	16163(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY increases|dobj|gene increases|nsubj|END_ENTITY	IL-13 increases the cPLA2 gene and protein expression and the mobilization of arachidonic_acid during an inflammatory process in mouse peritoneal macrophages .
14695653	0	cPLA2	22,27	IL-1_beta	31,40	cPLA2	IL-1 beta	5321	3553	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	The mediating role of cPLA2 in IL-1_beta and IL-6 release in LPS-induced HeLa cells .
8607793	0	cPLA2	28,33	IL-1beta	72,80	cPLA2	IL-1beta	5321	3553	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The concerted regulation of cPLA2 , COX2 , and lipocortin_1 expression by IL-1beta in A549 cells .
16963226	0	cPLA2	61,66	PKCalpha	0,8	cPLA2	PKCalpha	5321	5578	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PKCalpha regulates phosphorylation and enzymatic activity of cPLA2 in vitro and in activated human monocytes .
17483741	0	cPLA2	104,109	p38_MAP_kinase	15,29	cPLA2	p38 MAP kinase	24653(Tax:10116)	81649(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p38_MAP_kinase in burn-induced degradation of membrane phospholipids and upregulation of cPLA2 in cardiac myocytes .
8706669	1	cPLA2	136,141	p42	145,148	cPLA2	p42	5321	23552	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity .
15685208	0	cPLA2	72,77	phospholipase_A2	7,23	cPLA2	phospholipase A2	5321	151056	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Spinal phospholipase_A2 in inflammatory hyperalgesia : role of group IVA cPLA2 .
12676927	0	cPLA2_alpha	202,213	sPLA2	186,191	cPLA2 alpha	sPLA2	18783(Tax:10090)	18780(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Cross-talk between cytosolic phospholipase_A2 alpha -LRB- cPLA2_alpha -RRB- and secretory phospholipase_A2 -LRB- sPLA2 -RRB- in hydrogen_peroxide-induced arachidonic_acid release in murine mesangial cells : sPLA2 regulates cPLA2_alpha activity that is responsible for arachidonic_acid release .
12676927	0	cPLA2_alpha	53,64	sPLA2	98,103	cPLA2 alpha	sPLA2	18783(Tax:10090)	18780(Tax:10090)	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Cross-talk between cytosolic phospholipase_A2 alpha -LRB- cPLA2_alpha -RRB- and secretory phospholipase_A2 -LRB- sPLA2 -RRB- in hydrogen_peroxide-induced arachidonic_acid release in murine mesangial cells : sPLA2 regulates cPLA2_alpha activity that is responsible for arachidonic_acid release .
18691014	0	cPLA2alpha	45,55	Ceramide_kinase	0,15	cPLA2alpha	Ceramide kinase	5321	64781	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Ceramide_kinase and the ceramide-1-phosphate / cPLA2alpha interaction as a therapeutic target .
18025046	0	cPLA2alpha	70,80	Nucleolin	0,9	cPLA2alpha	Nucleolin	5321	4691	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of cPLA2alpha in phorbol_ester-treated non-small_cell_lung_cancer A549 cells .
23499864	0	cPRLR	50,55	prolactin_receptor	30,48	cPRLR	prolactin receptor	395660(Tax:9031)	395660(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of prolactin_receptor -LRB- cPRLR -RRB- gene in chickens : gene structure , tissue expression , promoter analysis , and its interaction with chicken prolactin -LRB- cPRL -RRB- and prolactin-like_protein -LRB- cPRL-L -RRB- .
3015290	0	cRABP	70,75	cRBP	36,40	cRABP	cRBP	1381	5947	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	-LSB- Presence of free retinol receptor -LRB- cRBP -RRB- and retinoic_acid receptor -LRB- cRABP -RRB- in human skin_tumors -RSB- .
3015290	0	cRBP	36,40	cRABP	70,75	cRBP	cRABP	5947	1381	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	-LSB- Presence of free retinol receptor -LRB- cRBP -RRB- and retinoic_acid receptor -LRB- cRABP -RRB- in human skin_tumors -RSB- .
25633199	0	cREL	69,73	BIRC3	44,49	cREL	BIRC3	5966	330	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival .
9135156	0	cRel	77,81	NF-kappa_B	82,92	cRel	NF-kappa B	5966	4790	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	I_kappa_B_epsilon , a novel member of the I kappa B family , controls RelA and cRel NF-kappa_B activity .
9929748	0	cTnI	32,36	cardiac_troponin-I	12,30	cTnI	cardiac troponin-I	7137	7137	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of cardiac_troponin-I -LRB- cTnI -RRB- in risk stratification of patients with unstable coronary_artery_disease .
26165658	0	cTnT	50,54	cardiac_troponin-T	30,48	cTnT	cardiac troponin-T	7139	7139	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	The effect of elapsed time on cardiac_troponin-T -LRB- cTnT -RRB- degradation and its relation to postmortem interval in cases of electrocution .
26971187	0	cTnT	50,54	cardiac_troponin-T	30,48	cTnT	cardiac troponin-T	7139	7139	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	The effect of elapsed time on cardiac_troponin-T -LRB- cTnT -RRB- degradation and its dependency on the cause of death .
25726526	0	c_oxidase_subunit_4	27,46	BMI1	57,61	c oxidase subunit 4	BMI1	1327	648	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nuclear-encoded cytochrome c_oxidase_subunit_4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas .
11719263	0	c_oxidase_subunit_Vb	11,31	androgen_receptor	53,70	c oxidase subunit Vb	androgen receptor	1329	367	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Cytochrome c_oxidase_subunit_Vb interacts with human androgen_receptor : a potential mechanism for neurotoxicity in spinobulbar muscular atrophy .
19538730	0	ca125	44,49	muc16	37,42	ca125	muc16	73732(Tax:10090)	73732(Tax:10090)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the tumor marker muc16 -LRB- ca125 -RRB- expressed by murine ovarian_tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies .
1855214	0	cachectin	22,31	Tumor_necrosis_factor	0,21	cachectin	Tumor necrosis factor	24835(Tax:10116)	103694380	Gene	Gene	decreases|nsubj|START_ENTITY END_ENTITY|parataxis|decreases	Tumor_necrosis_factor / cachectin decreases catalase activity of rat liver .
2475571	0	cachectin	22,31	Tumor_necrosis_factor	0,21	cachectin	Tumor necrosis factor	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	Tumor_necrosis_factor / cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis .
3119758	0	cachectin	22,31	Tumor_necrosis_factor	0,21	cachectin	Tumor necrosis factor	24835(Tax:10116)	103694380	Gene	Gene	stimulates|nsubj|START_ENTITY END_ENTITY|parataxis|stimulates	Tumor_necrosis_factor / cachectin stimulates peritoneal macrophages , polymorphonuclear neutrophils , and vascular endothelial cells to synthesize and release platelet-activating factor .
2154202	0	cachectin	28,37	Tumor_necrosis_factor-alpha	0,27	cachectin	Tumor necrosis factor-alpha	7124	7124	Gene	Gene	activates|nsubj|START_ENTITY END_ENTITY|parataxis|activates	Tumor_necrosis_factor-alpha / cachectin activates the O2 -LRB- - -RRB- - generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic_acid .
3282023	0	cachectin	28,37	Tumor_necrosis_factor_alpha	0,27	cachectin	Tumor necrosis factor alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	factor|nsubj|START_ENTITY END_ENTITY|parataxis|factor	Tumor_necrosis_factor_alpha / cachectin is a growth factor for thymocytes .
3095481	0	cachectin	30,39	gamma_interferon	10,26	cachectin	gamma interferon	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of gamma_interferon on cachectin expression by mononuclear phagocytes .
2195296	0	cachectin	50,59	interleukin-1_and_tumor_necrosis_factor	10,49	cachectin	interleukin-1 and tumor necrosis factor	24835(Tax:10116)	103694380	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin-1_and_tumor_necrosis_factor / cachectin on glucose turnover in the rat .
2244888	0	cachectin	32,41	low_density_lipoprotein_receptor	65,97	cachectin	low density lipoprotein receptor	7124	3949	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of tumor_necrosis_factor / cachectin on the activity of the low_density_lipoprotein_receptor on human skin fibroblasts .
2244888	0	cachectin	32,41	tumor_necrosis_factor	10,31	cachectin	tumor necrosis factor	7124	7124	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor / cachectin on the activity of the low_density_lipoprotein_receptor on human skin fibroblasts .
2307938	1	cachectin	91,100	tumor_necrosis_factor	69,90	cachectin	tumor necrosis factor	7124	7124	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Cell surface expression of tumor_necrosis_factor / cachectin by activated normal human T cells .
2785120	0	cachectin	34,43	tumor_necrosis_factor	12,33	cachectin	tumor necrosis factor	24835(Tax:10116)	103694380	Gene	Gene	promotes|nsubj|START_ENTITY Infusion|parataxis|promotes Infusion|nmod|END_ENTITY	Infusion of tumor_necrosis_factor / cachectin promotes muscle catabolism in the rat .
3132919	0	cachectin	36,45	tumor_necrosis_factor	14,35	cachectin	tumor necrosis factor	24835(Tax:10116)	103694380	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	The effect of tumor_necrosis_factor / cachectin on follicle-stimulating hormone-induced aromatase activity in cultured rat granulosa cells .
3202418	0	cachectin	53,62	tumor_necrosis_factor	31,52	cachectin	tumor necrosis factor	7124	7124	Gene	Gene	gene|compound|START_ENTITY expression|dep|gene expression|nmod|END_ENTITY	Differential expression of the tumor_necrosis_factor / cachectin gene by blood and lung mononuclear phagocytes .
3263462	0	cachectin	36,45	tumor_necrosis_factor	14,35	cachectin	tumor necrosis factor	7124	7124	Gene	Gene	Production|dep|START_ENTITY Production|nmod|END_ENTITY	Production of tumor_necrosis_factor / cachectin by human B cell lines and tonsillar B cells .
3402392	0	cachectin	39,48	tumor_necrosis_factor-alpha	11,38	cachectin	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of tumor_necrosis_factor-alpha / cachectin on thyroid hormone metabolism in mice .
3495589	0	cachectin	49,58	tumor_necrosis_factor-alpha	21,48	cachectin	tumor necrosis factor-alpha	7124	7124	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Disparate effects of tumor_necrosis_factor-alpha / cachectin and tumor_necrosis_factor-beta / lymphotoxin on hematopoietic_growth_factor production and neutrophil adhesion molecule expression by cultured human endothelial cells .
2104745	0	cachectin	54,63	tumor_necrosis_factor_alpha	26,53	cachectin	tumor necrosis factor alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel tumor_necrosis_factor_alpha / cachectin from the livers of burned and infected rats .
3426563	0	cachectin	51,60	tumour_necrosis_factor	27,49	cachectin	tumour necrosis factor	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of recombinant tumour_necrosis_factor -LRB- cachectin -RRB- on metabolism in isolated rat adipocyte , hepatocyte and muscle preparations .
21798287	0	cadherin-11	16,27	IL-17	0,5	cadherin-11	IL-17	12552(Tax:10090)	16171(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	IL-17 increases cadherin-11 expression in a model of autoimmune_experimental_arthritis and in rheumatoid_arthritis .
10320525	0	cadherin-11	103,114	cadherin-11	59,70	cadherin-11	cadherin-11	1009	1009	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11 .
10320525	0	cadherin-11	59,70	cadherin-11	103,114	cadherin-11	cadherin-11	1009	1009	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11 .
8725287	0	cadherin-11	24,35	cadherin-11	74,85	cadherin-11	cadherin-11	1009	1009	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Regulated expression of cadherin-11 in human epithelial cells : a role for cadherin-11 in trophoblast-endometrium interactions ?
8725287	0	cadherin-11	74,85	cadherin-11	24,35	cadherin-11	cadherin-11	1009	1009	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Regulated expression of cadherin-11 in human epithelial cells : a role for cadherin-11 in trophoblast-endometrium interactions ?
18353622	0	cadherin-17	49,60	CDX2	111,115	cadherin-17	CDX2	1015	1045	Gene	Gene	expression|nmod|START_ENTITY study|nmod|expression study|appos|END_ENTITY	A clinicopathological study on the expression of cadherin-17 and caudal-related_homeobox_transcription_factor -LRB- CDX2 -RRB- in human gastric_carcinoma .
23178988	0	cadherin-7	33,43	MicroRNA-375	0,12	cadherin-7	MicroRNA-375	1005	494324	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	MicroRNA-375 , a new regulator of cadherin-7 , suppresses the migration of chondrogenic progenitors .
18348277	0	cadherin_23	39,50	CDH23	52,57	cadherin 23	CDH23	64072	64072	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in the cadherin_23 -LRB- CDH23 -RRB- gene in Polish workers exposed to industrial noise .
20958966	0	cadherin_23	79,90	PIST	0,4	cadherin 23	PIST	22295(Tax:10090)	94221(Tax:10090)	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	PIST regulates the intracellular trafficking and plasma membrane expression of cadherin_23 .
10063232	0	cadherin_5	32,42	VE-cadherin	44,55	cadherin 5	VE-cadherin	1003	1003	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	An immunohistochemical study of cadherin_5 -LRB- VE-cadherin -RRB- in vascular endothelial cells in placentas with gestosis .
11585719	0	cadherin_6	14,24	BARX2	0,5	cadherin 6	BARX2	1004	8538	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	BARX2 induces cadherin_6 expression and is a functional suppressor of ovarian_cancer progression .
15940789	0	cagA	14,18	CagA	25,29	cagA	CagA	6279	6279	Gene	Gene	gene|compound|START_ENTITY gene|appos|protein protein|compound|END_ENTITY	-LSB- Detection of cagA gene , CagA protein in Helicobacter_pylori isolates and its antibody in serum of patients with gastric_diseases by a recombinant protein CagA 1 -RSB- .
2166565	0	calbindin_D9k	16,29	Ca2	0,3	calbindin D9k	Ca2	795	760	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Ca2 + binding to calbindin_D9k strongly affects backbone dynamics : measurements of exchange rates of individual amide protons using 1H NMR .
18755154	0	calcineurin_B	15,28	PICK1	0,5	calcineurin B	PICK1	5534	84591(Tax:10116)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	PICK1 binds to calcineurin_B and modulates the NFAT activity in PC12 cells .
2849490	0	calcitonin	54,64	calcitonin_gene-related_peptide	12,43	calcitonin	calcitonin gene-related peptide	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Calcitonin , calcitonin_gene-related_peptide and renal calcitonin receptors in the Zucker rat .
12697724	0	calcitonin	160,170	transforming_growth_factor_beta_1	123,156	calcitonin	transforming growth factor beta 1	24241(Tax:10116)	59086(Tax:10116)	Gene	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Antiproliferative action of calcitonin on lactotrophs of the rat anterior pituitary gland : evidence for the involvement of transforming_growth_factor_beta_1 in calcitonin action .
8392334	0	calcitonin-gene-related_neuropeptide	116,152	amylin	160,166	calcitonin-gene-related neuropeptide	amylin	796	3375	Gene	Gene	START_ENTITY|dep|receptor receptor|compound|END_ENTITY	A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related_neuropeptide -LRB- CGRP -RRB- / amylin receptor .
12196117	0	calcitonin-gene-related_peptide	57,88	CGRP	90,94	calcitonin-gene-related peptide	CGRP	796	796	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Development and potential of non-peptide antagonists for calcitonin-gene-related_peptide -LRB- CGRP -RRB- receptors : evidence for CGRP receptor heterogeneity .
18007068	0	calcitonin-gene-related_peptide	11,42	MMP-9	46,51	calcitonin-gene-related peptide	MMP-9	796	4318	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	-LSB- Effect of calcitonin-gene-related_peptide on MMP-9 production in human bronchial epithelial cells -RSB- .
10880881	0	calcitonin-gene_related_peptide	29,60	CGRP	62,66	calcitonin-gene related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of central calcitonin-gene_related_peptide -LRB- CGRP -RRB- on pancreatic secretion in conscious rats .
7880590	0	calcitonin_gene-related_peptide	64,95	7B2	36,39	calcitonin gene-related peptide	7B2	24241(Tax:10116)	25719(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Immunohistochemical distribution of 7B2 and colocalization with calcitonin_gene-related_peptide in rat lung .
18772068	0	calcitonin_gene-related_peptide	28,59	ALDH2	147,152	calcitonin gene-related peptide	ALDH2	796	217	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Evidence for involvement of calcitonin_gene-related_peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 -LRB- ALDH2 -RRB- Glu504Lys polymorphism .
23731651	0	calcitonin_gene-related_peptide	56,87	CCR4	129,133	calcitonin gene-related peptide	CCR4	796	1233	Gene	Gene	induces|xcomp|START_ENTITY induces|nmod|END_ENTITY	CCL17/thymus and activation-regulated chemokine induces calcitonin_gene-related_peptide in human airway epithelial cells through CCR4 .
10425745	0	calcitonin_gene-related_peptide	12,43	CGRP	45,49	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of calcitonin_gene-related_peptide -LRB- CGRP -RRB- - containing nerve fibres in the rat spinal cord using light and electron microscopy .
10877837	0	calcitonin_gene-related_peptide	21,52	CGRP	54,58	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	A novel receptor for calcitonin_gene-related_peptide -LRB- CGRP -RRB- mediates secretion in the rat colon : implications for secretory function in colitis .
11324552	0	calcitonin_gene-related_peptide	14,45	CGRP	47,51	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- mRNA in rat lymphocytes .
11396788	0	calcitonin_gene-related_peptide	60,91	CGRP	93,97	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of vasoactive_intestinal_polypeptide _ -LRB- VIP -RRB- and calcitonin_gene-related_peptide -LRB- CGRP -RRB- expression in stellate ganglia of children with congenital cardiovascular_lesions .
11576394	0	calcitonin_gene-related_peptide	10,41	CGRP	43,47	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on motility and on the release of substance_P , neurokinin_A , somatostatin and gastrin in the isolated perfused porcine antrum .
11642727	0	calcitonin_gene-related_peptide	13,44	CGRP	46,50	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of calcitonin_gene-related_peptide -LRB- CGRP -RRB- by rat arterial endothelial cells .
11804624	0	calcitonin_gene-related_peptide	20,51	CGRP	53,57	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Characterization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors and their receptor-activity-modifying_proteins -LRB- RAMPs -RRB- in human brain microvascular and astroglial cells in culture .
11985877	0	calcitonin_gene-related_peptide	63,94	CGRP	96,100	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Reciprocal age-related changes in GAP-43 / B-50 , substance P and calcitonin_gene-related_peptide -LRB- CGRP -RRB- expression in rat primary sensory neurones and their terminals in the dorsal horn of the spinal cord and subintima of the knee synovium .
12220736	0	calcitonin_gene-related_peptide	8,39	CGRP	41,45	calcitonin gene-related peptide	CGRP	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in chronic hypoxia-induced pulmonary_hypertension in the mouse .
12855330	0	calcitonin_gene-related_peptide	12,43	CGRP	45,49	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin .
1310134	0	calcitonin_gene-related_peptide	57,88	CGRP	90,94	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Pharmacological evidence for the involvement of multiple calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in the antisecretory and antiulcer effect of CGRP in rat stomach .
15085045	0	calcitonin_gene-related_peptide	14,45	CGRP	47,51	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in irreversible acute pulpitis .
15228501	0	calcitonin_gene-related_peptide	15,46	CGRP	48,52	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Effects of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats .
15623815	0	calcitonin_gene-related_peptide	23,54	CGRP	56,60	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Evidence for decreased calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies .
16438955	0	calcitonin_gene-related_peptide	12,43	CGRP	45,49	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in ischemic preconditioning in isolated rat hearts .
17027165	0	calcitonin_gene-related_peptide	48,79	CGRP	81,85	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Muscle_inflammation induces a rapid increase in calcitonin_gene-related_peptide -LRB- CGRP -RRB- mRNA that temporally relates to CGRP immunoreactivity and nociceptive_behavior .
18186028	0	calcitonin_gene-related_peptide	92,123	CGRP	125,129	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Calcitonin_receptor-like_receptor -LRB- CLR -RRB- , receptor_activity-modifying_protein_1 -LRB- RAMP1 -RRB- , and calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in the rat trigeminovascular system : differences between peripheral and central CGRP receptor distribution .
1873010	0	calcitonin_gene-related_peptide	23,54	CGRP	56,60	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Normal serum levels of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in mild to moderate essential_hypertension .
18835571	0	calcitonin_gene-related_peptide	10,41	CGRP	43,47	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on avian appetite-related processes .
1889317	0	calcitonin_gene-related_peptide	12,43	CGRP	45,49	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	-LSB- Changes of calcitonin_gene-related_peptide -LRB- CGRP -RRB- concentrations in CSF in patients with cerebrovascular_disorders -RSB- .
19053766	0	calcitonin_gene-related_peptide	89,120	CGRP	122,126	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Identification of potent , selective , and metabolically stable peptide antagonists to the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor .
1980300	0	calcitonin_gene-related_peptide	21,52	CGRP	54,58	calcitonin gene-related peptide	CGRP	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Inhibitory action of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in the mouse colon .
20855369	0	calcitonin_gene-related_peptide	14,45	CGRP	47,51	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Effect of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist telcagepant in human cranial arteries .
2359517	0	calcitonin_gene-related_peptide	11,42	CGRP	44,48	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of calcitonin_gene-related_peptide -LRB- CGRP -RRB- from capsaicin-sensitive vasodilator nerves in the rat mesenteric artery .
23674158	0	calcitonin_gene-related_peptide	14,45	CGRP	47,51	calcitonin gene-related peptide	CGRP	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of calcitonin_gene-related_peptide -LRB- CGRP -RRB- has the potential to extend first-phase insulin secretion .
23868210	0	calcitonin_gene-related_peptide	27,58	CGRP	60,64	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Peptide antagonists of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor with improved pharmacokinetics and pharmacodynamics .
2390722	0	calcitonin_gene-related_peptide	11,42	CGRP	44,48	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in calcitonin_gene-related_peptide -LRB- CGRP -RRB- - containing vasodilator nerve activity in hypertension .
2394085	0	calcitonin_gene-related_peptide	14,45	CGRP	47,51	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on human forearm blood flow .
23993336	0	calcitonin_gene-related_peptide	36,67	CGRP	69,73	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Preparation of imidazoles as potent calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonists .
2536276	0	calcitonin_gene-related_peptide	50,81	CGRP	83,87	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and characterisation of immunoreactive calcitonin_gene-related_peptide -LRB- CGRP -RRB- from a CGRP receptor-positive cloned osteosarcoma cell line -LRB- UMR 106.01 -RRB- .
2557987	0	calcitonin_gene-related_peptide	25,56	CGRP	58,62	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated serum levels of calcitonin_gene-related_peptide -LRB- CGRP -RRB- but no evidence for CGRP gene expression in non-small cell lung_carcinomas .
25670002	0	calcitonin_gene-related_peptide	51,82	CGRP	84,88	calcitonin gene-related peptide	CGRP	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Microglial content-dependent inhibitory effects of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on murine retroviral_infection of glial cells .
2579983	0	calcitonin_gene-related_peptide	27,58	CGRP	60,64	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Distribution and origin of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in the sensory innervation of the mammalian eye .
2613943	0	calcitonin_gene-related_peptide	15,46	CGRP	48,52	calcitonin gene-related peptide	CGRP	396256(Tax:9031)	396256(Tax:9031)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Development of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in relationship to the formation of neuromuscular junctions in Xenopus myotomal muscle .
26231160	0	calcitonin_gene-related_peptide	20,51	CGRP	53,57	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
26231160	0	calcitonin_gene-related_peptide	20,51	CGRP	53,57	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel oxazolidinone calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonists for the acute treatment of migraine .
26832218	0	calcitonin_gene-related_peptide	21,52	CGRP	54,58	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and SAR of calcitonin_gene-related_peptide -LRB- CGRP -RRB- antagonists containing substituted aryl-piperazines and piperidines .
27021026	0	calcitonin_gene-related_peptide	27,58	CGRP	60,64	calcitonin gene-related peptide	CGRP	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression and function of calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in trigeminal ganglia of R192Q Cacna1a knock-in mice .
2786708	0	calcitonin_gene-related_peptide	28,59	CGRP	61,65	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	-LSB- Radioimmunoassay of plasma calcitonin_gene-related_peptide -LRB- CGRP -RRB- levels in patients with endocrine_tumor -RSB- .
2843180	0	calcitonin_gene-related_peptide	44,75	CGRP	77,81	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Positive inotropic effects and receptors of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in porcine ventricular muscles .
2854248	0	calcitonin_gene-related_peptide	33,64	CGRP	66,70	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Autoradiographic localization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- binding sites in human and guinea_pig lung .
2886386	0	calcitonin_gene-related_peptide	11,42	CGRP	44,48	calcitonin gene-related peptide	CGRP	100124407(Tax:9823)	100124407(Tax:9823)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of calcitonin_gene-related_peptide -LRB- CGRP -RRB- on islet hormone secretion in the pig .
3118566	0	calcitonin_gene-related_peptide	27,58	CGRP	60,64	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	796	Gene	Gene	localization|nmod|START_ENTITY Studies|nmod|localization Studies|appos|END_ENTITY	Studies on localization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in the thyroid-parathyroid complex .
3265774	0	calcitonin_gene-related_peptide	16,47	CGRP	49,53	calcitonin gene-related peptide	CGRP	796	796	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- at a neuronal nicotinic synapse .
3282604	0	calcitonin_gene-related_peptide	37,68	CGRP	70,74	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immuno-electron microscopic study of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in axis cylinders of the vagus nerve .
3498561	0	calcitonin_gene-related_peptide	32,63	CGRP	65,69	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	796	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Basal and stimulated release of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in patients with medullary_thyroid_carcinoma .
7507998	0	calcitonin_gene-related_peptide	48,79	CGRP	81,85	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Pharmacological characterization of presynaptic calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors on CGRP-containing vasodilator nerves in rat mesenteric resistance vessels .
7967233	0	calcitonin_gene-related_peptide	36,67	CGRP	69,73	calcitonin gene-related peptide	CGRP	396256(Tax:9031)	396256(Tax:9031)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Structure-activity study of chicken calcitonin_gene-related_peptide -LRB- CGRP -RRB- on vasorelaxation in rat mesenteric resistance vessels .
8105830	0	calcitonin_gene-related_peptide	21,52	CGRP	54,58	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Early changes in the calcitonin_gene-related_peptide -LRB- CGRP -RRB- content of pulmonary endocrine cells concomitant with vascular remodeling in the hypoxic rat .
8182554	0	calcitonin_gene-related_peptide	31,62	CGRP	64,68	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Binding profile of a selective calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor antagonist ligand , -LSB- 125I-Tyr -RSB- hCGRP8-37 , in rat brain and peripheral tissues .
8278635	0	calcitonin_gene-related_peptide	22,53	CGRP	55,59	calcitonin gene-related peptide	CGRP	12310(Tax:10090)	24241(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Characterization of a calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptor on mouse bone marrow cells .
8698903	0	calcitonin_gene-related_peptide	33,64	CGRP	66,70	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Sexually dimorphic expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity by rat mediobasal hypothalamic neurons .
8745063	0	calcitonin_gene-related_peptide	30,61	CGRP	63,67	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- in a rat medullary thyroid_carcinoma cell line .
8750870	0	calcitonin_gene-related_peptide	33,64	CGRP	66,70	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Sexually dimorphic expression of calcitonin_gene-related_peptide -LRB- CGRP -RRB- mRNA in rat medial_preoptic_nucleus .
9272685	0	calcitonin_gene-related_peptide	45,76	CGRP	78,82	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Evidence for a physiological role of central calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in the control of food intake in rats .
9469578	0	calcitonin_gene-related_peptide	120,151	CGRP	153,157	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- protects dorsal root ganglion neurons from death and induces calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in vitro .
9579744	0	calcitonin_gene-related_peptide	20,51	CGRP	53,57	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Characterization of calcitonin_gene-related_peptide -LRB- CGRP -RRB- receptors in intramural coronary arteries from male and female Sprague_Dawley_rats .
9606032	0	calcitonin_gene-related_peptide	23,54	CGRP	56,60	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Relaxant effect of the calcitonin_gene-related_peptide -LRB- CGRP -RRB- on the nonpregnant and pregnant rat uterus .
9660718	0	calcitonin_gene-related_peptide	43,74	CGRP	76,80	calcitonin gene-related peptide	CGRP	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Morphological evidence for the location of calcitonin_gene-related_peptide -LRB- CGRP -RRB- immunoreactivity in rat lymphocytes .
2457810	0	calcitonin_gene-related_peptide	50,81	Substance_P	0,11	calcitonin gene-related peptide	Substance P	796	6863	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Substance_P regulates the vasodilator activity of calcitonin_gene-related_peptide .
9366515	0	calcitonin_gene-related_peptide	50,81	TNF-alpha	26,35	calcitonin gene-related peptide	TNF-alpha	12310(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of LPS-induced TNF-alpha production by calcitonin_gene-related_peptide -LRB- CGRP -RRB- in cultured mouse peritoneal macrophages .
9417811	0	calcitonin_gene-related_peptide	17,48	TNF-alpha	58,67	calcitonin gene-related peptide	TNF-alpha	24241(Tax:10116)	24835(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The neuropeptide calcitonin_gene-related_peptide inhibits TNF-alpha but poorly induces IL-6 production by fetal rat osteoblasts .
12135324	0	calcitonin_gene-related_peptide	81,112	adrenomedullin	32,46	calcitonin gene-related peptide	adrenomedullin	24241(Tax:10116)	25026(Tax:10116)	Gene	Gene	comparison|nmod|START_ENTITY effects|dep|comparison effects|nmod|END_ENTITY	Regional hemodynamic effects of adrenomedullin in Wistar_rats : a comparison with calcitonin_gene-related_peptide .
10051146	0	calcitonin_gene-related_peptide	27,58	amylin	15,21	calcitonin gene-related peptide	amylin	796	3375	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Interaction of amylin with calcitonin_gene-related_peptide receptors in the microvasculature of the hamster cheek pouch in vivo .
2468474	0	calcitonin_gene-related_peptide	15,46	atrial_natriuretic_peptide	50,76	calcitonin gene-related peptide	atrial natriuretic peptide	24241(Tax:10116)	24602(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Stimulation by calcitonin_gene-related_peptide of atrial_natriuretic_peptide secretion in vitro and its mechanism of action .
20432624	0	calcitonin_gene-related_peptide	15,46	bFGF	50,54	calcitonin gene-related peptide	bFGF	24241(Tax:10116)	54250(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	The effects of calcitonin_gene-related_peptide on bFGF and AQP4 expression after focal cerebral_ischemia reperfusion in rats .
2849490	0	calcitonin_gene-related_peptide	12,43	calcitonin	54,64	calcitonin gene-related peptide	calcitonin	24241(Tax:10116)	24241(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Calcitonin , calcitonin_gene-related_peptide and renal calcitonin receptors in the Zucker rat .
16101891	0	calcitonin_gene-related_peptide	10,41	gonadotrophin-releasing_hormone	45,76	calcitonin gene-related peptide	gonadotrophin-releasing hormone	796	2796	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of calcitonin_gene-related_peptide on gonadotrophin-releasing_hormone mRNA expression in GT1-7 cells .
10233692	0	calcitonin_gene-related_peptide	71,102	interleukin-6	133,146	calcitonin gene-related peptide	interleukin-6	12310(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Role of nitric_oxide and prostaglandins in the potentiating effects of calcitonin_gene-related_peptide on lipopolysaccharide-induced interleukin-6 release from mouse peritoneal macrophages .
15823252	0	calcitonin_gene-related_peptide	49,80	nerve_growth_factor	26,45	calcitonin gene-related peptide	nerve growth factor	796	4803	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	The effect of endoneurial nerve_growth_factor on calcitonin_gene-related_peptide expression in primary sensory neurons .
20973063	0	calcitonin_gene-related_peptide	62,93	nerve_growth_factor	11,30	calcitonin gene-related peptide	nerve growth factor	24241(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Inhibiting nerve_growth_factor or its receptors downregulates calcitonin_gene-related_peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs .
9685362	0	calcitonin_gene-related_peptide	82,113	phospholipase_C-beta1	14,35	calcitonin gene-related peptide	phospholipase C-beta1	796	23236	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of phospholipase_C-beta1 via Galphaq/11 during calcium mobilization by calcitonin_gene-related_peptide .
9533810	0	calcitonin_gene-related_peptide	11,42	somatostatin	46,58	calcitonin gene-related peptide	somatostatin	24241(Tax:10116)	24797(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of calcitonin_gene-related_peptide on somatostatin and gastrin gene expression in rat antrum .
15761654	0	calcitonin_gene-related_peptide	24,55	substance_P	64,75	calcitonin gene-related peptide	substance P	796	6863	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association between calcitonin_gene-related_peptide -LRB- CGRP -RRB- , substance_P and headache in pituitary_tumours .
20197606	0	calcitonin_gene-related_peptide	10,41	triggering_receptor_expressed_on_myeloid_cells-1	63,111	calcitonin gene-related peptide	triggering receptor expressed on myeloid cells-1	796	54210	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of calcitonin_gene-related_peptide on the expression of triggering_receptor_expressed_on_myeloid_cells-1 in lipopolysaccharide-induced macrophages .
20143189	0	calcitonin_gene_related_peptide	62,93	CGRP	95,99	calcitonin gene related peptide	CGRP	796	796	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Breast density , scintimammographic -LRB- 99m -RRB- Tc -LRB- V -RRB- DMSA uptake , and calcitonin_gene_related_peptide -LRB- CGRP -RRB- expression in mixed invasive ductal associated with extensive in __ situ_ductal_carcinoma -LRB- IDC + DCIS -RRB- and pure_invasive_ductal_carcinoma -LRB- IDC -RRB- : correlation with estrogen_receptor -LRB- ER -RRB- status , proliferation index Ki-67 , and histological grade .
8846401	0	calcitonin_gene_related_peptide	11,42	CGRP	44,48	calcitonin gene related peptide	CGRP	12310(Tax:10090)	12310(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for calcitonin_gene_related_peptide -LRB- CGRP -RRB- in the regulation of early B lymphocyte differentiation .
8846438	0	calcitonin_gene_related_peptide	64,95	CGRP	97,101	calcitonin gene related peptide	CGRP	796	796	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Multiple affinity and guanine_nucleotide sensitive forms of the calcitonin_gene_related_peptide -LRB- CGRP -RRB- receptor .
12730726	0	calcitonin_receptor	40,59	Calcr	0,5	calcitonin receptor	Calcr	12311(Tax:10090)	12311(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Calcr , a brain-specific imprinted mouse calcitonin_receptor gene in the imprinted cluster of the proximal region of chromosome 6 .
9677414	0	calcitonin_receptor	4,23	Shc	35,38	calcitonin receptor	Shc	799	6464	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	The calcitonin_receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation .
12086988	0	calcitonin_receptor-like_receptor	32,65	CGRP	127,131	calcitonin receptor-like receptor	CGRP	25029(Tax:10116)	24241(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Comparison of the expression of calcitonin_receptor-like_receptor -LRB- CRLR -RRB- and receptor activity modifying proteins -LRB- RAMPs -RRB- with CGRP and adrenomedullin binding in cell lines .
14747444	0	calcitonin_receptor-like_receptor	38,71	CRLR	73,77	calcitonin receptor-like receptor	CRLR	10203	10203	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The immunohistochemical expression of calcitonin_receptor-like_receptor -LRB- CRLR -RRB- in human gliomas .
14980499	0	calcium-calmodulin-dependent_kinase_I-like_kinase	30,79	CKLiK	81,86	calcium-calmodulin-dependent kinase I-like kinase	CKLiK	227541(Tax:10090)	227541(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of PU.1-induced mouse calcium-calmodulin-dependent_kinase_I-like_kinase -LRB- CKLiK -RRB- on apoptosis of murine_erythroleukemia cells .
9162070	0	calcium-dependent_tyrosine_kinase	78,111	Paxillin	0,8	calcium-dependent tyrosine kinase	Paxillin	50646(Tax:10116)	360820(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent_tyrosine_kinase in rat liver epithelial cells .
15488321	0	calcium-responsive_transactivator	4,37	CREB_binding_protein	47,67	calcium-responsive transactivator	CREB binding protein	192352(Tax:10116)	54244(Tax:10116)	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The calcium-responsive_transactivator recruits CREB_binding_protein to nuclear bodies .
11668634	0	calcium-sensing_receptor	40,64	CASR	66,70	calcium-sensing receptor	CASR	846	846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An acceptor splice site mutation in the calcium-sensing_receptor -LRB- CASR -RRB- gene in familial_hypocalciuric_hypercalcemia and neonatal_severe_hyperparathyroidism .
12580936	0	calcium-sensing_receptor	108,132	CaR	134,137	calcium-sensing receptor	CaR	846	846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two Italian kindreds with familial_hypocalciuric_hypercalcaemia caused by loss-of-function mutations in the calcium-sensing_receptor -LRB- CaR -RRB- gene : functional characterization of a novel CaR missense mutation .
19003284	0	calcium-sensing_receptor	95,119	CaSR	121,125	calcium-sensing receptor	CaSR	24247(Tax:10116)	24247(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tissue specific expression and differential regulation by 1alpha,25-dihydroxyvitamin _ D3 of the calcium-sensing_receptor -LRB- CaSR -RRB- gene in rat kidney , intestine , and calvaria .
23856260	0	calcium-sensing_receptor	69,93	CaSR	95,99	calcium-sensing receptor	CaSR	846	846	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The CASR gene : alternative splicing and transcriptional control , and calcium-sensing_receptor -LRB- CaSR -RRB- protein : structure and ligand binding sites .
25500736	0	calcium-sensing_receptor	27,51	CaSR	53,57	calcium-sensing receptor	CaSR	12374(Tax:10090)	12374(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	pH-sensitive expression of calcium-sensing_receptor -LRB- CaSR -RRB- in type-B intercalated cells of the cortical_collecting_ducts -LRB- CCD -RRB- in mouse kidney .
16377269	0	calcium-sensing_receptor	4,28	PTHrP	39,44	calcium-sensing receptor	PTHrP	12374(Tax:10090)	19227(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	The calcium-sensing_receptor regulates PTHrP production and calcium transport in the lactating mammary gland .
20473557	0	calcium-sensing_receptor	29,53	THP-1	76,81	calcium-sensing receptor	THP-1	846	2736	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	The functional expression of calcium-sensing_receptor in the differentiated THP-1 cells .
12783889	0	calcium-sensing_receptor	31,55	m-Calpain	0,9	calcium-sensing receptor	m-Calpain	281038(Tax:9913)	281662(Tax:9913)	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	m-Calpain colocalizes with the calcium-sensing_receptor -LRB- CaR -RRB- in caveolae in parathyroid cells and participates in degradation of the CaR .
10940742	0	calcium-sensing_receptor	42,66	parathyroid_hormone	77,96	calcium-sensing receptor	parathyroid hormone	846	5741	Gene	Gene	gene|amod|START_ENTITY gene|nmod|secretion secretion|amod|END_ENTITY	Association of polymorphic alleles of the calcium-sensing_receptor gene with parathyroid_hormone secretion in hemodialysis patients .
12671051	0	calcium-sensing_receptor	4,28	parathyroid_hormone	87,106	calcium-sensing receptor	parathyroid hormone	12374(Tax:10090)	19226(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|homeostasis homeostasis|nmod|END_ENTITY	The calcium-sensing_receptor is required for normal calcium homeostasis independent of parathyroid_hormone .
15775479	0	calcium-sensing_receptor	25,49	parathyroid_hormone	82,101	calcium-sensing receptor	parathyroid hormone	846	5741	Gene	Gene	mutations|nmod|START_ENTITY cause|nsubj|mutations cause|dobj|secretion secretion|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Activating mutations of calcium-sensing_receptor cause insufficient secretion of parathyroid_hormone -RSB- .
16189180	0	calcium-sensing_receptor	33,57	parathyroid_hormone	129,148	calcium-sensing receptor	parathyroid hormone	12374(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY parathyroid|dobj|expression parathyroid|advcl|suppressing suppressing|dobj|secretion secretion|amod|END_ENTITY	Relationship between parathyroid calcium-sensing_receptor expression and potency of the calcimimetic , cinacalcet , in suppressing parathyroid_hormone secretion in an in vivo murine model of primary_hyperparathyroidism .
16983178	0	calcium-sensing_receptor	128,152	parathyroid_hormone	10,29	calcium-sensing receptor	parathyroid hormone	846	5741	Gene	Gene	mutation|nmod|START_ENTITY caused|nmod|mutation caused|nsubj|Effect Effect|nmod|administration administration|amod|END_ENTITY	Effect of parathyroid_hormone administration in a patient with severe hypoparathyroidism caused by gain-of-function mutation of calcium-sensing_receptor .
19397786	0	calcium-sensing_receptor	4,28	parathyroid_hormone	39,58	calcium-sensing receptor	parathyroid hormone	846	5741	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The calcium-sensing_receptor regulates parathyroid_hormone gene expression in transfected HEK293 cells .
19474191	0	calcium-sensing_receptor	16,40	parathyroid_hormone	125,144	calcium-sensing receptor	parathyroid hormone	12374(Tax:10090)	19226(Tax:10090)	Gene	Gene	dampens|nsubj|START_ENTITY dampens|nmod|vivo vivo|nmod|END_ENTITY	The full-length calcium-sensing_receptor dampens the calcemic response to 1alpha ,25 -LRB- OH -RRB- 2_vitamin_D3 in vivo independently of parathyroid_hormone .
19797241	0	calcium-sensing_receptor	4,28	parathyroid_hormone	101,120	calcium-sensing receptor	parathyroid hormone	12374(Tax:10090)	19226(Tax:10090)	Gene	Gene	defends|nsubj|START_ENTITY defends|nmod|hypercalcemia hypercalcemia|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	The calcium-sensing_receptor -LRB- CaSR -RRB- defends against hypercalcemia independently of its regulation of parathyroid_hormone secretion .
21306167	0	calcium-sensing_receptor	44,68	parathyroid_hormone	106,125	calcium-sensing receptor	parathyroid hormone	24247(Tax:10116)	24694(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY Discovery|nmod|antagonists Discovery|acl:relcl|stimulate stimulate|dobj|secretion secretion|compound|END_ENTITY	Discovery of novel and potent orally active calcium-sensing_receptor antagonists that stimulate pulselike parathyroid_hormone secretion : synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives .
21810422	0	calcium-sensing_receptor	26,50	parathyroid_hormone	84,103	calcium-sensing receptor	parathyroid hormone	24247(Tax:10116)	24694(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY JTT-305|appos|antagonist stimulates|nsubj|JTT-305 stimulates|dobj|release release|compound|END_ENTITY	JTT-305 , an orally active calcium-sensing_receptor antagonist , stimulates transient parathyroid_hormone release and bone formation in ovariectomized rats .
14966569	0	calcium-sensing_receptor	4,28	parathyroid_hormone-related_protein	53,88	calcium-sensing receptor	parathyroid hormone-related protein	846	5744	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	The calcium-sensing_receptor regulates mammary gland parathyroid_hormone-related_protein production and calcium transport .
24454825	0	calcium_sensing_receptor	65,89	receptor_activity_modifying_protein_1	8,45	calcium sensing receptor	receptor activity modifying protein 1	846	10267	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of receptor_activity_modifying_protein_1 in function of the calcium_sensing_receptor in the human TT_thyroid_carcinoma cell line .
11200185	0	calcyclin	42,51	S100A6	53,59	calcyclin	S100A6	6277	6277	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of cell specific expression of calcyclin -LRB- S100A6 -RRB- in nerve cells and other tissues .
16288473	0	calcyclin	78,87	S100A6	70,76	calcyclin	S100A6	6277	6277	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Binding and functional characteristics of two E-box motifs within the S100A6 -LRB- calcyclin -RRB- gene promoter .
18714402	0	calcyclin	39,48	S100A6	55,61	calcyclin	S100A6	6277	6277	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	P53-dependent suppression of the human calcyclin gene -LRB- S100A6 -RRB- : the role of Sp1 and of NFkappaB .
20013795	0	calcyclin	8,17	S100A6	0,6	calcyclin	S100A6	20200(Tax:10090)	20200(Tax:10090)	Gene	Gene	induces|dep|START_ENTITY induces|nsubj|END_ENTITY	S100A6 -LRB- calcyclin -RRB- deficiency induces senescence-like changes in cell cycle , morphology and functional characteristics of mouse NIH 3T3 fibroblasts .
9497364	0	calcyclin	14,23	S100A6	25,31	calcyclin	S100A6	100348755(Tax:9986)	100348755(Tax:9986)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of calcyclin -LRB- S100A6 -RRB- binding by alternative splicing in the N-terminal regulatory domain of annexin_XI isoforms .
12746458	0	calcyclin	51,60	Sgt1	33,37	calcyclin	Sgt1	6277	10910	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Calcium-regulated interaction of Sgt1 with S100A6 -LRB- calcyclin -RRB- and other S100 proteins .
8973570	0	calcyclin	37,46	p30	0,3	calcyclin	p30	20200(Tax:10090)	15289(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	p30 , a novel protein target of mouse calcyclin -LRB- S100A6 -RRB- .
16289137	0	calcyclin-binding_protein	38,63	CacyBP	65,71	calcyclin-binding protein	CacyBP	12301(Tax:10090)	12301(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Expression and hormonal regulation of calcyclin-binding_protein -LRB- CacyBP -RRB- in the mouse uterus during early pregnancy .
18443365	0	calcyclin-binding_protein	14,39	Siah-1_interacting_protein	40,66	calcyclin-binding protein	Siah-1 interacting protein	27101	27101	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of calcyclin-binding_protein / Siah-1_interacting_protein in normal and malignant human tissues : an immunohistochemical survey .
12006993	0	calcyclin_binding_protein	33,58	hCacyBP	60,67	calcyclin binding protein	hCacyBP	27101	27101	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Cloning and expression of human calcyclin_binding_protein -LRB- hCacyBP -RRB- gene -RSB- .
15668896	0	calgizzarin	36,47	S100A11	27,34	calgizzarin	S100A11	6282	6282	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Dysregulated expression of S100A11 -LRB- calgizzarin -RRB- in prostate_cancer and precursor lesions .
16327996	0	calgizzarin	24,35	S100A11	37,44	calgizzarin	S100A11	6282	6282	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Different expression of calgizzarin -LRB- S100A11 -RRB- in normal colonic epithelium , adenoma and colorectal_carcinoma .
16082188	0	calgranulin-B	23,36	S100A9	38,44	calgranulin-B	S100A9	6280	6280	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Psoriasin -LRB- S100A7 -RRB- and calgranulin-B -LRB- S100A9 -RRB- induction is dependent on reactive oxygen species and is downregulated by Bcl-2 and antioxidants .
17158877	0	calgranulin_C	10,23	receptor_for_advanced_glycated_end_products	47,90	calgranulin C	receptor for advanced glycated end products	6283	177	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Hexameric calgranulin_C -LRB- S100A12 -RRB- binds to the receptor_for_advanced_glycated_end_products -LRB- RAGE -RRB- using symmetric hydrophobic target-binding patches .
2146368	0	calmodulin	28,38	B-50	53,57	calmodulin	B-50	808	2596	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Evidence for the binding of calmodulin to endogenous B-50 -LRB- GAP-43 -RRB- in native synaptosomal_plasma_membranes .
20802526	0	calmodulin	50,60	K-Ras	75,80	calmodulin	K-Ras	808	3845	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function .
10679575	0	calmodulin	80,90	MARCKS	36,42	calmodulin	MARCKS	808	4082	Gene	Gene	alter|nmod|START_ENTITY alter|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Thrombin-induced phosphorylation of MARCKS does not alter its interactions with calmodulin or actin .
16046479	0	calmodulin	45,55	MARCKS	0,6	calmodulin	MARCKS	808	4082	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MARCKS is a major PKC-dependent regulator of calmodulin targeting in smooth muscle .
7840634	0	calmodulin	113,123	MARCKS	55,61	calmodulin	MARCKS	808	4082	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nsubj|responses responses|dep|END_ENTITY	Differential responses of protein_kinase_C substrates -LRB- MARCKS , neuromodulin , and neurogranin -RRB- phosphorylation to calmodulin and S100 .
1693693	0	calmodulin	39,49	Myelin_basic_protein	0,20	calmodulin	Myelin basic protein	100352392(Tax:9986)	100344447(Tax:9986)	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	Myelin_basic_protein : interaction with calmodulin and gangliosides .
8235618	0	calmodulin	14,24	NINAC	59,64	calmodulin	NINAC	36329(Tax:7227)	34012(Tax:7227)	Gene	Gene	Dependence|nmod|START_ENTITY localization|nsubj|Dependence localization|nmod|retina retina|nmod|myosin myosin|compound|END_ENTITY	Dependence of calmodulin localization in the retina on the NINAC unconventional myosin .
23204517	0	calmodulin	4,14	PEP-19	34,40	calmodulin	PEP-19	808	5121	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The calmodulin regulator protein , PEP-19 , sensitizes ATP-induced Ca2 + release .
23170925	0	calmodulin	17,27	PTPRZ1	0,6	calmodulin	PTPRZ1	808	5803	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell_lung_carcinoma .
8886974	0	calmodulin	35,45	Spc110p	19,26	calmodulin	Spc110p	852406(Tax:4932)	851957(Tax:4932)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The spacer protein Spc110p targets calmodulin to the central plaque of the yeast spindle pole body .
14695896	0	calmodulin	62,72	androgen_receptor	39,56	calmodulin	androgen receptor	808	367	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of androgen_receptor with calmodulin in prostate_cancer cells .
14960328	0	calmodulin	11,21	epidermal_growth_factor_receptor	41,73	calmodulin	epidermal growth factor receptor	808	1956	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Endogenous calmodulin interacts with the epidermal_growth_factor_receptor in living cells .
17316976	0	calmodulin	73,83	estrogen_receptor_alpha	100,123	calmodulin	estrogen receptor alpha	808	2099	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Calmodulin-independent , agonistic properties of a peptide containing the calmodulin binding site of estrogen_receptor_alpha .
17291992	0	calmodulin	81,91	interleukin-12_p40	22,40	calmodulin	interleukin-12 p40	808	3593	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Nitric_oxide inhibits interleukin-12_p40 through p38 MAPK-mediated regulation of calmodulin and c-rel .
16306123	0	calmodulin	15,25	mTRPC5	73,79	calmodulin	mTRPC5	808	22067(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Involvement of calmodulin and myosin_light_chain_kinase in activation of mTRPC5 expressed in HEK cells .
7681659	0	calmodulin-binding_protein	65,91	Atrial_natriuretic_factor	0,25	calmodulin-binding protein	Atrial natriuretic factor	654502	4878	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Atrial_natriuretic_factor stimulates phosphorylation of a 52-kDa calmodulin-binding_protein in vascular smooth muscle cells .
21896713	0	calmodulin-dependent_kinase	5,32	CaMK	34,38	calmodulin-dependent kinase	CaMK	814	814	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Ca2 + / calmodulin-dependent_kinase -LRB- CaMK -RRB- signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy .
21896713	0	calmodulin-dependent_kinase	5,32	CaMKI	54,59	calmodulin-dependent kinase	CaMKI	814	8536	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Ca2 + / calmodulin-dependent_kinase -LRB- CaMK -RRB- signaling via CaMKI and AMP-activated protein kinase contributes to the regulation of WIPI-1 at the onset of autophagy .
12641734	0	calmodulin-dependent_serine_kinase	97,131	CIP98	0,5	calmodulin-dependent serine kinase	CIP98	8573	25861	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CIP98 , a novel PDZ domain protein , is expressed in the central nervous system and interacts with calmodulin-dependent_serine_kinase .
19166543	0	calmodulin-like_protein	6,29	CLP	31,34	calmodulin-like protein	CLP	810	810	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human calmodulin-like_protein -LRB- CLP -RRB- expression in oral squamous mucosa and in malignant transformation .
15225611	0	calmodulin_2	33,45	p53	67,70	calmodulin 2	p53	816	7157	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Cell type-specific regulation of calmodulin_2 expression by mutant p53 .
15173200	0	calnexin	69,77	Cne1p	60,65	calnexin	Cne1p	851241(Tax:4932)	851241(Tax:4932)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Expression and characterization of Saccharomyces_cerevisiae Cne1p , a calnexin homologue .
8313912	0	calnexin	11,19	IP90	21,25	calnexin	IP90	821	821	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for calnexin -LRB- IP90 -RRB- in the assembly of class II MHC molecules .
26603938	0	calnexin	40,48	N-myristoyltransferase_1	0,24	calnexin	N-myristoyltransferase 1	821	4836	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	N-myristoyltransferase_1 interacts with calnexin at the endoplasmic reticulum .
12432081	0	calnexin	71,79	Sbh1p	0,5	calnexin	Sbh1p	851241(Tax:4932)	856821(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sbh1p , a subunit of the Sec61 translocon , interacts with the chaperone calnexin in the yeast Yarrowia_lipolytica .
12383251	0	calnexin	45,53	thyrotropin_receptor	19,39	calnexin	thyrotropin receptor	821	7253	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the thyrotropin_receptor with calnexin , calreticulin and BiP .
2136806	0	calpactin_II	52,64	Epidermal_growth_factor	0,23	calpactin II	Epidermal growth factor	25380(Tax:10116)	25313(Tax:10116)	Gene	Gene	accumulation|nmod|START_ENTITY induces|dobj|accumulation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces the accumulation of calpactin_II on the cell surface during membrane ruffling .
2138915	0	calpactin_I_heavy_chain	55,78	p36	50,53	calpactin I heavy chain	p36	12306(Tax:10090)	12306(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and chromosome assignment of the murine p36 -LRB- calpactin_I_heavy_chain -RRB- gene .
7823949	0	calpain	20,27	CalpA	0,5	calpain	CalpA	37232(Tax:7227)	37232(Tax:7227)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	CalpA , a Drosophila calpain homolog specifically expressed in a small set of nerve , midgut , and blood cells .
17576811	0	calpain-1	90,99	protein_tyrosine_phosphatase_1B	29,60	calpain-1	protein tyrosine phosphatase 1B	12333(Tax:10090)	19246(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Double knockouts reveal that protein_tyrosine_phosphatase_1B is a physiological target of calpain-1 in platelets .
17855447	0	calpain-10	28,38	CAPN10	45,51	calpain-10	CAPN10	11132	11132	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variation in calpain-10 gene -LRB- CAPN10 -RRB- and diabetes risk in a multi-ethnic cohort of American postmenopausal women .
21713405	0	calpain-3	46,55	CAPN3	57,62	calpain-3	CAPN3	423233(Tax:9031)	423233(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the expression profile of calpain-3 -LRB- CAPN3 -RRB- gene in chicken .
25327507	0	calpain_10	53,63	CAPN10	65,71	calpain 10	CAPN10	11132	11132	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A pharmacogenetic association between a variation in calpain_10 -LRB- CAPN10 -RRB- gene and the response to metformin treatment in patients with type 2 diabetes .
12105198	0	calpain_3	63,72	C/EBPalpha	0,10	calpain 3	C/EBPalpha	12335(Tax:10090)	12606(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	C/EBPalpha is required for proteolytic cleavage of cyclin_A by calpain_3 in myeloid precursor cells .
17318636	0	calpain_3	50,59	CAPN3	66,71	calpain 3	CAPN3	825	825	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A large deletion and novel point mutations in the calpain_3 gene -LRB- CAPN3 -RRB- in Bulgarian LGMD2A patients .
23567141	0	calpain_3	34,43	CAPN3	50,55	calpain 3	CAPN3	443038(Tax:9940)	443038(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in exon 10 of the ovine calpain_3 gene -LRB- CAPN3 -RRB- and its association with meat yield in New Zealand Romney sheep .
18073330	0	calpain_3	82,91	c-FLIP	59,65	calpain 3	c-FLIP	825	8837	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain_3 , the protein involved in limb-girdle muscular dystrophy_type_2A .
12105198	0	calpain_3	63,72	cyclin_A	51,59	calpain 3	cyclin A	12335(Tax:10090)	12428(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nmod|cleavage cleavage|nmod|END_ENTITY	C/EBPalpha is required for proteolytic cleavage of cyclin_A by calpain_3 in myeloid precursor cells .
16533054	0	calpain_3	19,28	p94	30,33	calpain 3	p94	825	825	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Ca2 + dependency of calpain_3 -LRB- p94 -RRB- activation .
15611136	0	calpain_4	25,34	AlphaPIX	0,8	calpain 4	AlphaPIX	826	9459	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	AlphaPIX associates with calpain_4 , the small subunit of calpain , and has a dual role in integrin-mediated cell spreading .
19649723	0	calpain_small_subunit	44,65	CAPNS1	67,73	calpain small subunit	CAPNS1	281664(Tax:9913)	281664(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new SNP in the 3 ` UTR region of the bovine calpain_small_subunit -LRB- CAPNS1 -RRB- gene .
18234454	0	calpain_small_subunit_1	51,74	CAPNS1	76,82	calpain small subunit 1	CAPNS1	826	826	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	NRF-1 , and AP-1 regulate the promoter of the human calpain_small_subunit_1 -LRB- CAPNS1 -RRB- gene .
18802795	0	calpastatin	38,49	CAST	51,55	calpastatin	CAST	443364(Tax:9940)	443364(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Haplotypic diversity within the ovine calpastatin -LRB- CAST -RRB- gene .
22062769	0	calpastatin	36,47	CAST	49,53	calpastatin	CAST	281039(Tax:9913)	281039(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allelic polymorphism of the caprine calpastatin -LRB- CAST -RRB- gene identified by PCR-SSCP .
24200570	0	calpastatin	44,55	CAST	57,61	calpastatin	CAST	831	831	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new single nucleotide polymorphism in the calpastatin -LRB- CAST -RRB- gene associated with beef tenderness .
17286756	0	calpastatin	86,97	SSB	81,84	calpastatin	SSB	831	6741	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Clinical significance of autoantibodies recognizing Sj gren 's syndrome A -LRB- SSA -RRB- , SSB , calpastatin and alpha-fodrin in primary Sj gren 's syndrome .
10413209	0	calreticulin	37,49	C1q	0,3	calreticulin	C1q	811	712	Gene	Gene	binding|nmod|START_ENTITY inhibits|xcomp|binding inhibits|nsubj|END_ENTITY	C1q inhibits autoantibody binding to calreticulin .
11560994	0	calreticulin	58,70	C1q	0,3	calreticulin	C1q	811	712	Gene	Gene	initiates|compound|START_ENTITY surface|dobj|initiates surface|nsubj|engagement engagement|compound|END_ENTITY	C1q and mannose_binding_lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells .
15140059	0	calreticulin	37,49	C1q	86,89	calreticulin	C1q	811	712	Gene	Gene	C1q|nmod|START_ENTITY Interaction|nmod|C1q requires|nsubj|Interaction requires|dobj|change change|nmod|END_ENTITY	Interaction of C1q with the receptor calreticulin requires a conformational change in C1q .
25454607	0	calreticulin	26,38	C1q	45,48	calreticulin	C1q	811	712	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Amblyomma americanum tick calreticulin binds C1q but does not inhibit activation of the classical complement cascade .
9476117	0	calreticulin	69,81	C1q	4,7	calreticulin	C1q	811	712	Gene	Gene	C1q_receptor|appos|START_ENTITY END_ENTITY|nmod|C1q_receptor	The C1q and collectin binding site within C1q_receptor -LRB- cell surface calreticulin -RRB- .
9777407	0	calreticulin	67,79	C1q	15,18	calreticulin	C1q	811	712	Gene	Gene	and_megalin|compound|START_ENTITY Interaction|nmod|and_megalin Interaction|nmod|END_ENTITY	Interaction of C1q and the collectins with the potential receptors calreticulin -LRB- cC1qR/collectin _ receptor -RRB- _ and_megalin .
9922153	0	calreticulin	104,116	C1q	14,17	calreticulin	C1q	811	712	Gene	Gene	present|nmod|START_ENTITY present|nsubj|Evidence Evidence|dep|binds binds|nsubj|END_ENTITY	Evidence that C1q binds specifically to CH2-like immunoglobulin gamma motifs present in the autoantigen calreticulin and interferes with complement activation .
17953526	0	calreticulin	15,27	CD40_ligand	33,44	calreticulin	CD40 ligand	811	959	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of calreticulin with CD40_ligand , TRAIL and Fas_ligand .
25398213	0	calreticulin	62,74	CRT	76,79	calreticulin	CRT	125972	811	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterisation and expression analysis of a novel calreticulin -LRB- CRT -RRB- gene in the dinoflagellate Prorocentrum minimum .
25130463	0	calreticulin	65,77	ERp29	19,24	calreticulin	ERp29	811	10961	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	PDI family protein ERp29 forms 1:1 complex with lectin chaperone calreticulin .
25378661	0	calreticulin	15,27	LIF	38,41	calreticulin	LIF	811	3976	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells .
16951317	0	calreticulin	23,35	NY-ESO-1	54,62	calreticulin	NY-ESO-1	811	246100	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Dendritic cell surface calreticulin is a receptor for NY-ESO-1 : direct interactions between tumor-associated antigen and the innate immune system .
22773372	0	calreticulin	64,76	Nerve_growth_factor	0,19	calreticulin	Nerve growth factor	811	4803	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Nerve_growth_factor induces the expression of chaperone protein calreticulin in human epithelial ovarian cells .
1911778	0	calreticulin	75,87	Ro/SS-A	58,65	calreticulin	Ro/SS-A	811	6737	Gene	Gene	antigen|appos|START_ENTITY antigen|amod|END_ENTITY	In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen -LRB- calreticulin -RRB- with a highly conserved amino_acid sequence in the cytoplasmic domain of integrin alpha subunits .
17395420	0	calreticulin	39,51	Tax	22,25	calreticulin	Tax	811	1491938(Tax:11908)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Interaction of HTLV-1 Tax protein with calreticulin : implications for Tax nuclear export and secretion .
19150386	0	calreticulin	68,80	androgen_receptor	32,49	calreticulin	androgen receptor	811	367	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|localization localization|nmod|END_ENTITY	Cytoplasmic localization of the androgen_receptor is independent of calreticulin .
22473608	0	calreticulin	35,47	c1q	60,63	calreticulin	c1q	811	712	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Entamoeba_histolytica cell surface calreticulin binds human c1q and functions in amebic phagocytosis of host cells .
24557008	0	calreticulin	56,68	c1q	25,28	calreticulin	c1q	811	712	Gene	Gene	START_ENTITY|nsubj|contribution contribution|nmod|cell-surface cell-surface|amod|END_ENTITY	Relative contribution of c1q and apoptotic cell-surface calreticulin to macrophage phagocytosis .
17438464	0	calreticulin	83,95	p38	65,68	calreticulin	p38	64202(Tax:10116)	81649(Tax:10116)	Gene	Gene	upregulation|compound|START_ENTITY upregulation|amod|END_ENTITY	Hypoxic preconditioning induces delayed cardioprotection through p38 MAPK-mediated calreticulin upregulation .
8537405	0	calreticulin	15,27	protein_disulfide_isomerase	33,60	calreticulin	protein disulfide isomerase	811	64714	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of calreticulin with protein_disulfide_isomerase .
24566135	0	calreticulin	8,20	tumor_necrosis_factor-a	29,52	calreticulin	tumor necrosis factor-a	811	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Soluble calreticulin induces tumor_necrosis_factor-a -LRB- TNF-a -RRB- and interleukin _ -LRB- IL -RRB- -6 production by macrophages through mitogen-activated protein kinase -LRB- MAPK -RRB- and NFkB signaling pathways .
15561962	0	calsequestrin_1	20,35	CASQ1	37,42	calsequestrin 1	CASQ1	844	844	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the calsequestrin_1 -LRB- CASQ1 -RRB- gene on chromosome 1q21 is associated with type 2 diabetes in the old order Amish .
16481613	0	calstabin2	12,22	ryanodine_receptor	34,52	calstabin2	ryanodine receptor	14226(Tax:10090)	20190(Tax:10090)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|dep|END_ENTITY	Analysis of calstabin2 -LRB- FKBP12 .6 -RRB- - ryanodine_receptor interactions : rescue of heart_failure by calstabin2 in mice .
16481613	0	calstabin2	94,104	ryanodine_receptor	34,52	calstabin2	ryanodine receptor	14226(Tax:10090)	20190(Tax:10090)	Gene	Gene	heart_failure|nmod|START_ENTITY rescue|nmod|heart_failure Analysis|dep|rescue Analysis|dep|END_ENTITY	Analysis of calstabin2 -LRB- FKBP12 .6 -RRB- - ryanodine_receptor interactions : rescue of heart_failure by calstabin2 in mice .
9284939	0	canalicular_multispecific_organic_anion_transporter	18,69	CMOAT	76,81	canalicular multispecific organic anion transporter	CMOAT	25303(Tax:10116)	1244	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the canalicular_multispecific_organic_anion_transporter gene -LRB- CMOAT -RRB- to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization .
10590227	0	canalicular_multispecific_organic_anion_transporter	27,78	cMOAT	80,85	canalicular multispecific organic anion transporter	cMOAT	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of canalicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver .
8797578	0	canalicular_multispecific_organic_anion_transporter	8,59	cMOAT	61,66	canalicular multispecific organic anion transporter	cMOAT	1244	1244	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A human canalicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased_drug_accumulation .
9556204	0	canalicular_multispecific_organic_anion_transporter	58,109	cMOAT	111,116	canalicular multispecific organic anion transporter	cMOAT	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Differential expression of multidrug resistance -LRB- mdr -RRB- and canalicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- genes following extrahepatic biliary_obstruction in rats .
17028776	0	cancer-associated_gene	22,44	focal_adhesion_kinase	108,129	cancer-associated gene	focal adhesion kinase	168400	5747	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|activation activation|nmod|END_ENTITY	Cancer/testis antigen cancer-associated_gene -LRB- CAGE -RRB- promotes motility of cancer cells through activation of focal_adhesion_kinase -LRB- FAK -RRB- .
24384540	0	cancer-related_anemia	41,62	GDF-15	31,37	cancer-related anemia	GDF-15	10903	9518	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hepcidin through GDF-15 in cancer-related_anemia .
2452770	0	cancer_antigen_125	12,30	CA_125	32,38	cancer antigen 125	CA 125	94025	94025	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of cancer_antigen_125 -LRB- CA_125 -RRB- in the management_of_ovarian_epithelial_carcinomas .
3864535	0	cancer_antigen_125	25,43	CA_125	45,51	cancer antigen 125	CA 125	94025	94025	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of cancer_antigen_125 -LRB- CA_125 -RRB- in ovarian_cancer .
9425227	0	canilicular_multispecific_organic_anion_transporter	17,68	cMOAT	70,75	canilicular multispecific organic anion transporter	cMOAT	1244	1244	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the canilicular_multispecific_organic_anion_transporter -LRB- cMOAT -RRB- gene , a novel ABC transporter , in patients with hyperbilirubinemia II/Dubin-Johnson _ syndrome .
10394995	0	cannabinoid	12,23	CB1	25,28	cannabinoid	CB1	1268	1268	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Blockade of cannabinoid -LRB- CB1 -RRB- receptors by 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils .
16639008	0	cannabinoid	42,53	CB1	55,58	cannabinoid	CB1	1268	1268	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Noladin_ether acts on trabecular meshwork cannabinoid -LRB- CB1 -RRB- receptors to enhance aqueous humor outflow facility .
16440297	0	cannabinoid-1	26,39	CB1	41,44	cannabinoid-1	CB1	25248(Tax:10116)	25248(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Targeting dopamine D2 and cannabinoid-1 -LRB- CB1 -RRB- receptors in rat nucleus accumbens .
19130142	0	cannabinoid-1	46,59	CB1	61,64	cannabinoid-1	CB1	574142(Tax:9544)	574142(Tax:9544)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	PET imaging studies in rhesus_monkey with the cannabinoid-1 -LRB- CB1 -RRB- receptor ligand -LSB- 11C -RSB- CB-119 .
21075633	0	cannabinoid-1	44,57	CB1	59,62	cannabinoid-1	CB1	1268	1268	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 -LRB- CB1 -RRB- antagonists : journey from non-polar to polar amides .
21741835	0	cannabinoid-1	88,101	CB1	103,106	cannabinoid-1	CB1	12801(Tax:10090)	12801(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Structure-activity relationship studies of novel pyrazole and imidazole_carboxamides as cannabinoid-1 -LRB- CB1 -RRB- antagonists .
12663043	0	cannabinoid-2	88,101	CB2	103,106	cannabinoid-2	CB2	1269	1269	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Effects of D3 .49 A , R3 .50 A , and A6 .34 E mutations on ligand binding and activation of the cannabinoid-2 -LRB- CB2 -RRB- receptor .
19552692	0	cannabinoid-2	25,38	CB2	40,43	Cannabinoid-2	CB2	1269	1269	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Constitutive activity of cannabinoid-2 -LRB- CB2 -RRB- receptors plays an essential role in the protean agonism of -LRB- + -RRB- AM1241 and L768242 .
21129839	0	cannabinoid_1_receptor	26,48	CNR1	50,54	cannabinoid 1 receptor	CNR1	1268	1268	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common variation in the cannabinoid_1_receptor -LRB- CNR1 -RRB- gene is associated with pre-eclampsia in the Central European population .
17539892	0	cannabinoid_2	18,31	CB2	33,36	cannabinoid 2	CB2	12802(Tax:10090)	12802(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Activation of the cannabinoid_2 -LRB- CB2 -RRB- receptor inhibits murine mesenteric afferent nerve activity .
18270474	0	cannabinoid_2	38,51	CB2	53,56	cannabinoid 2	CB2	57302(Tax:10116)	57302(Tax:10116)	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Pharmacological evaluation of a novel cannabinoid_2 -LRB- CB2 -RRB- ligand , PF-03550096 , in vitro and in vivo by using a rat model of visceral_hypersensitivity .
22371074	0	cannabinoid_2	13,26	CB2	28,31	cannabinoid 2	CB2	1269	1269	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Interplay of cannabinoid_2 -LRB- CB2 -RRB- receptors with nitric_oxide synthases , oxidative and nitrative stress , and cell death during remote neurodegeneration .
16563642	0	cannabinoid_receptor	24,44	CB1	20,23	cannabinoid receptor	CB1	1268	1268	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of CB1 cannabinoid_receptor immunoreactivity in postmortem human brain homogenates .
21472841	0	cannabinoid_receptor	39,59	CB1	61,64	cannabinoid receptor	CB1	1268	1268	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relation of G1359A polymorphism of the cannabinoid_receptor -LRB- CB1 -RRB- gene with metabolic_syndrome by ATP III classification .
24182233	0	cannabinoid_receptor	106,126	CB1	128,131	cannabinoid receptor	CB1	1268	1268	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid_receptor -LRB- CB1 -RRB- antagonists with desired pharmacokinetic properties .
10441206	0	cannabinoid_receptor	56,76	CNR1	78,82	cannabinoid receptor	CNR1	1268	1268	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A frequent polymorphism in the coding exon of the human cannabinoid_receptor -LRB- CNR1 -RRB- gene .
19420965	0	cannabinoid_receptor-1	32,54	CNR1	56,60	cannabinoid receptor-1	CNR1	1268	1268	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide change in the cannabinoid_receptor-1 -LRB- CNR1 -RRB- gene in colorectal_cancer outcome .
21875798	0	cannabinoid_receptor_1	27,49	CB1	51,54	cannabinoid receptor 1	CB1	1268	1268	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Towards rational design of cannabinoid_receptor_1 -LRB- CB1 -RRB- antagonists for peripheral selectivity .
19443135	0	cannabinoid_receptor_1	24,46	CNR1	53,57	cannabinoid receptor 1	CNR1	1268	1268	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association between cannabinoid_receptor_1 gene -LRB- CNR1 -RRB- and cannabis_dependence symptoms in adolescents and young adults .
19725030	0	cannabinoid_receptor_1	25,47	CNR1	54,58	cannabinoid receptor 1	CNR1	1268	1268	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter variants of the cannabinoid_receptor_1 gene -LRB- CNR1 -RRB- in interaction with 5-HTTLPR affect the anxious phenotype .
20107430	0	cannabinoid_receptor_1	29,51	CNR1	53,57	cannabinoid receptor 1	CNR1	1268	1268	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common polymorphism in the cannabinoid_receptor_1 -LRB- CNR1 -RRB- gene is associated with antipsychotic-induced weight_gain in Schizophrenia .
21266946	0	cannabinoid_receptor_1	21,43	CNR1	45,49	cannabinoid receptor 1	CNR1	1268	1268	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of cannabinoid_receptor_1 -LRB- CNR1 -RRB- gene in tardive_dyskinesia .
12970790	0	cannabinoid_receptor_1	14,36	Cyclin_D1	117,126	cannabinoid receptor 1	Cyclin D1	1268	595	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	High level of cannabinoid_receptor_1 , absence of regulator_of_G_protein_signalling_13 and differential expression of Cyclin_D1 in mantle_cell_lymphoma .
21626285	0	cannabinoid_receptor_2	31,53	CB2	55,58	cannabinoid receptor 2	CB2	1269	1269	Gene	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	Unraveling the complexities of cannabinoid_receptor_2 -LRB- CB2 -RRB- immune regulation in health and disease .
19496827	0	cannabinoid_receptor_2	23,45	CNR2	47,51	cannabinoid receptor 2	CNR2	1269	1269	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Species differences in cannabinoid_receptor_2 -LRB- CNR2 gene -RRB- : identification of novel human and rodent CB2 isoforms , differential tissue expression and regulation by cannabinoid receptor ligands .
22789143	0	cannabinoid_receptor_type_1	49,76	CB1-R	78,83	cannabinoid receptor type 1	CB1-R	1268	1268	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Progesterone-dependent regulation of endometrial cannabinoid_receptor_type_1 -LRB- CB1-R -RRB- expression is disrupted in women with endometriosis and in isolated stromal cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
25843798	0	cannabinoid_receptor_type_1	39,66	Major_urinary_protein_1	0,23	cannabinoid receptor type 1	Major urinary protein 1	12801(Tax:10090)	17840(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Major_urinary_protein_1 interacts with cannabinoid_receptor_type_1 in fatty_acid-induced hepatic insulin resistance in a mouse hepatocyte model .
25843798	0	cannabinoid_receptor_type_1	39,66	Major_urinary_protein_1	0,23	cannabinoid receptor type 1	Major urinary protein 1	12801(Tax:10090)	17840(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Major_urinary_protein_1 interacts with cannabinoid_receptor_type_1 in fatty_acid-induced hepatic insulin resistance in a mouse hepatocyte model .
24055403	0	cannabinoid_receptor_type_1	63,90	androgen_receptor	12,29	cannabinoid receptor type 1	androgen receptor	25248(Tax:10116)	24208(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	The role of androgen_receptor in transcriptional modulation of cannabinoid_receptor_type_1 gene in rat trigeminal_ganglia .
19565271	0	cannabinoid_receptor_type_2	4,31	CNR2	33,37	cannabinoid receptor type 2	CNR2	1269	1269	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The cannabinoid_receptor_type_2 -LRB- CNR2 -RRB- gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample .
17118807	0	cannabinoid_type-2	39,57	CB2	59,62	cannabinoid type-2	CB2	1269	1269	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	New natural noncannabinoid ligands for cannabinoid_type-2 -LRB- CB2 -RRB- receptors .
16864584	0	cannabinoid_type_1	35,53	Krox-24	13,20	cannabinoid type 1	Krox-24	12801(Tax:10090)	13653(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Induction of Krox-24 by endogenous cannabinoid_type_1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway .
16477641	0	cannonball	169,179	don_juan	15,23	cannonball	don juan	45432(Tax:7227)	40838(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	In Drosophila , don_juan and don_juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF_II80 cannonball while translational repression is achieved by distinct elements .
6283140	0	cap-binding_protein	15,34	eucaryotic_initiation_factor_3	40,70	cap-binding protein	eucaryotic initiation factor 3	1977	8661	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of cap-binding_protein with eucaryotic_initiation_factor_3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells .
11110696	0	cappuccino	15,25	cno	27,30	cappuccino	cno	117197(Tax:10090)	117197(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Defects in the cappuccino -LRB- cno -RRB- gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak_syndrome by an AP-3-independent mechanism .
19537933	0	capsaicin_receptor	85,103	MCS-18	10,16	capsaicin receptor	MCS-18	83810(Tax:10116)	100302898(Tax:10116)	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin_receptor , TRPV1 , in rat cultured sensory neurons .
11825677	0	capsaicin_receptor	14,32	VR1	34,37	capsaicin receptor	VR1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of capsaicin_receptor -LRB- VR1 -RRB- by myelinated primary afferent neurons in rats .
20615868	0	carbohydrate-response_element-binding_protein	75,120	ChREBP	122,128	carbohydrate-response element-binding protein	ChREBP	58805(Tax:10090)	58805(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Thyroid_hormone_receptor_beta -LRB- TRbeta -RRB- and liver X receptor -LRB- LXR -RRB- regulate carbohydrate-response_element-binding_protein -LRB- ChREBP -RRB- expression in a tissue-selective manner .
20615868	0	carbohydrate-response_element-binding_protein	75,120	Thyroid_hormone_receptor_beta	0,29	carbohydrate-response element-binding protein	Thyroid hormone receptor beta	58805(Tax:10090)	21834(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Thyroid_hormone_receptor_beta -LRB- TRbeta -RRB- and liver X receptor -LRB- LXR -RRB- regulate carbohydrate-response_element-binding_protein -LRB- ChREBP -RRB- expression in a tissue-selective manner .
23803610	0	carbohydrate_response_element-binding_protein	20,65	FOXO1	0,5	carbohydrate response element-binding protein	FOXO1	51085	2308	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	FOXO1 competes with carbohydrate_response_element-binding_protein -LRB- ChREBP -RRB- and inhibits thioredoxin-interacting_protein -LRB- TXNIP -RRB- transcription in pancreatic beta cells .
23530060	0	carbohydrate_response_element_binding_protein	62,107	Farnesoid_X_receptor	0,20	carbohydrate response element binding protein	Farnesoid X receptor	51085	9971	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Farnesoid_X_receptor inhibits the transcriptional activity of carbohydrate_response_element_binding_protein in human hepatocytes .
14735064	0	carbohydrate_sulfotransferase-6	23,54	CHST6	56,61	carbohydrate sulfotransferase-6	CHST6	4166	4166	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations of the carbohydrate_sulfotransferase-6 -LRB- CHST6 -RRB- gene causing macular corneal_dystrophy in India .
15953452	0	carbohydrate_sulfotransferase_6	23,54	CHST6	56,61	carbohydrate sulfotransferase 6	CHST6	4166	4166	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Different mutations in carbohydrate_sulfotransferase_6 -LRB- CHST6 -RRB- gene cause macular corneal_dystrophy_types_I and II in a single sibship .
8980526	0	carbonic_anhydrase	28,46	Cah1	53,57	carbonic anhydrase	Cah1	5717875(Tax:3055)	5717875(Tax:3055)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Circadian expression of the carbonic_anhydrase gene , Cah1 , in Chlamydomonas_reinhardtii .
19008051	0	carbonic_anhydrase-9	38,58	CA-9	60,64	carbonic anhydrase-9	CA-9	768	768	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Assessment of microvessel density and carbonic_anhydrase-9 -LRB- CA-9 -RRB- expression in rectal_cancer .
23360090	0	carbonic_anhydrase-II	21,42	hCA-II	44,50	carbonic anhydrase-II	hCA-II	760	760	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	An interactive human carbonic_anhydrase-II -LRB- hCA-II -RRB- receptor -- pharmacophore molecular model _ anti-convulsant activity of the designed and synthesized 5-amino-1 ,3,4 - thiadiazole-2-thiol conjugated imine derivatives .
22609543	0	carbonic_anhydrase_1	15,35	Ldb1	0,4	carbonic anhydrase 1	Ldb1	759	8861	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Ldb1 regulates carbonic_anhydrase_1 during erythroid differentiation .
9651514	0	carbonic_anhydrase_3	76,96	CA3	98,101	carbonic anhydrase 3	CA3	761	761	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence comparisons and functional studies of the proximal promoter of the carbonic_anhydrase_3 -LRB- CA3 -RRB- gene .
17852557	0	carbonic_anhydrase_9	55,75	CA9	77,80	carbonic anhydrase 9	CA9	768	768	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hypoxia inducible factor -LRB- HIf1alpha and HIF2alpha -RRB- and carbonic_anhydrase_9 -LRB- CA9 -RRB- expression and response of head-neck_cancer to hypofractionated and accelerated radiotherapy .
3107918	0	carbonic_anhydrase_II	19,40	CA2	42,45	carbonic anhydrase II	CA2	760	760	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for human carbonic_anhydrase_II -LRB- CA2 -RRB- is located at chromosome 8q22 .
3095084	0	carbonic_anhydrase_II	20,41	CAII	43,47	carbonic anhydrase II	CAII	12349(Tax:10090)	12349(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Early expression of carbonic_anhydrase_II -LRB- CAII -RRB- in transitory glial cells of the developing murine nervous system .
10542985	0	carbonic_anhydrase_II	36,57	CO2	15,18	carbonic anhydrase II	CO2	760	717	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency END_ENTITY|nmod|patients	Elimination of CO2 in patients with carbonic_anhydrase_II deficiency , with studies of respiratory function at rest .
2111014	0	carbonic_anhydrase_II	53,74	CO2	21,24	carbonic anhydrase II	CO2	760	717	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of substrate CO2 to the active site of human carbonic_anhydrase_II : a molecular dynamics study .
3126084	0	carbonic_anhydrase_II	70,91	CO2	38,41	carbonic anhydrase II	CO2	760	717	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Histidine 64 is not required for high CO2 hydration activity of human carbonic_anhydrase_II .
3126803	0	carbonic_anhydrase_II	143,164	CO2	84,87	carbonic anhydrase II	CO2	760	717	Gene	Gene	catalyzed|nmod|START_ENTITY reactions|acl|catalyzed basis|dep|reactions basis|dep|interaction interaction|nmod|ion ion|nmod|hydration hydration|compound|END_ENTITY	Molecular basis of ionic strength effects : interaction of enzyme and sulfate ion in CO2 hydration and HCO3 - dehydration reactions catalyzed by carbonic_anhydrase_II .
6433979	0	carbonic_anhydrase_II	53,74	CO2	20,23	carbonic anhydrase II	CO2	760	717	Gene	Gene	catalyzed|nmod|START_ENTITY catalyzed|nsubj|inhibition inhibition|nmod|hydration hydration|compound|END_ENTITY	Anion inhibition of CO2 hydration catalyzed by human carbonic_anhydrase_II .
16687407	0	carbonic_anhydrase_II	16,37	NBCe1-A	102,109	carbonic anhydrase II	NBCe1-A	760	8671	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Effect of human carbonic_anhydrase_II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes .
17306833	0	carbonic_anhydrase_II	65,86	Receptor_activator_of_NF-kappaB_ligand	0,38	carbonic anhydrase II	Receptor activator of NF-kappaB ligand	12349(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Receptor_activator_of_NF-kappaB_ligand induces the expression of carbonic_anhydrase_II , cathepsin_K , and matrix_metalloproteinase-9 in osteoclast precursor RAW264 .7 cells .
7529022	0	carbonic_anhydrase_II	54,75	Tumor_necrosis_factor-alpha	0,27	carbonic anhydrase II	Tumor necrosis factor-alpha	760	7124	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces the expression of carbonic_anhydrase_II in pancreatic_adenocarcinoma cells .
3099305	0	carbonic_anhydrase_III	17,39	CA_III	41,47	carbonic anhydrase III	CA III	761	761	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of human carbonic_anhydrase_III -LRB- CA_III -RRB- on synovial and muscle fibroblast glycosaminoglycan metabolism .
15930751	0	carbonic_anhydrase_III	15,37	aryl_hydrocarbon_receptor	55,80	carbonic anhydrase III	aryl hydrocarbon receptor	54232(Tax:10116)	25690(Tax:10116)	Gene	Gene	level|amod|START_ENTITY level|nmod|END_ENTITY	Suppression of carbonic_anhydrase_III mRNA level by an aryl_hydrocarbon_receptor ligand in primary cultured hepatocytes of rat .
26252502	0	carbonic_anhydrase_IX	14,35	CA9	37,40	carbonic anhydrase IX	CA9	230099(Tax:10090)	230099(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of carbonic_anhydrase_IX -LRB- CA9 -RRB- sensitizes renal_cell_carcinoma to ionizing radiation .
26252502	0	carbonic_anhydrase_IX	14,35	CA9	37,40	carbonic anhydrase IX	CA9	230099(Tax:10090)	230099(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of carbonic_anhydrase_IX -LRB- CA9 -RRB- sensitizes renal_cell_carcinoma to ionizing radiation .
21691815	0	carbonic_anhydrase_IX	18,39	CAIX	41,45	carbonic anhydrase IX	CAIX	768	768	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of carbonic_anhydrase_IX -LRB- CAIX -RRB- is an independent unfavorable prognostic marker in endometrioid ovarian_cancer .
24471939	0	carbonic_anhydrase_IX	14,35	CAIX	37,41	carbonic anhydrase IX	CAIX	768	768	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of carbonic_anhydrase_IX -LRB- CAIX -RRB- in malignant_mesothelioma .
15752902	0	carbonic_anhydrase_IX	20,41	CA_IX	43,48	carbonic anhydrase IX	CA IX	768	768	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of carbonic_anhydrase_IX -LRB- CA_IX -RRB- as an endogenous marker of chronic hypoxia in live human tumor cells .
18180112	1	carbonic_anhydrase_IX	131,152	CA_IX	154,159	carbonic anhydrase IX	CA IX	768	768	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A simulation study of the hypoxia marker carbonic_anhydrase_IX -LRB- CA_IX -RRB- in human soft tissue sarcoma .
24436269	0	carbonic_anhydrase_IX	36,57	CA_IX	59,64	carbonic anhydrase IX	CA IX	768	768	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical reevaluation of carbonic_anhydrase_IX -LRB- CA_IX -RRB- expression in tumors and normal tissues .
25843777	0	carbonic_anhydrase_IX	36,57	CREB	0,4	carbonic anhydrase IX	CREB	768	1385	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	CREB is a key negative regulator of carbonic_anhydrase_IX -LRB- CA9 -RRB- in gastric_cancer .
25843777	0	carbonic_anhydrase_IX	36,57	CREB	0,4	carbonic anhydrase IX	CREB	768	1385	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	CREB is a key negative regulator of carbonic_anhydrase_IX -LRB- CA9 -RRB- in gastric_cancer .
20127031	0	carbonic_anhydrase_IX	26,47	Src	0,3	carbonic anhydrase IX	Src	768	6714	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Src induces expression of carbonic_anhydrase_IX via hypoxia-inducible_factor_1 .
16270297	0	carbonic_anhydrase_IX	110,131	extracellular_signal-regulated_protein_kinase	12,57	carbonic anhydrase IX	extracellular signal-regulated protein kinase	768	5594	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of extracellular_signal-regulated_protein_kinase in transcriptional regulation of the hypoxia marker carbonic_anhydrase_IX .
10567219	0	carbonic_anhydrase_VI	17,38	CA6	40,43	carbonic anhydrase VI	CA6	765	765	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure of the carbonic_anhydrase_VI -LRB- CA6 -RRB- gene : evidence for two distinct groups within the alpha-CA gene family .
9147070	0	carbonic_anhydrase_VIII	29,52	Car8	59,63	carbonic anhydrase VIII	Car8	12319(Tax:10090)	12319(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the acatalytic carbonic_anhydrase_VIII gene , Car8 , during mouse embryonic development .
18449627	0	carbonyl_reductase_1	32,52	CBR1	54,58	carbonyl reductase 1	CBR1	873	873	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of polymorphic human carbonyl_reductase_1 -LRB- CBR1 -RRB- by the cardioprotectant flavonoid 7-monohydroxyethyl_rutoside -LRB- monoHER -RRB- .
22531821	0	carbonyl_reductase_1	13,33	CBR1	35,39	carbonyl reductase 1	CBR1	873	873	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of carbonyl_reductase_1 -LRB- CBR1 -RRB- expression in human lung tissues and lung_cancer cells by the cigarette smoke constituent benzo -LSB- a -RSB- pyrene .
23133646	0	carbonyl_reductase_1	34,54	CBR1	56,60	carbonyl reductase 1	CBR1	873	873	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	MicroRNAs differentially regulate carbonyl_reductase_1 -LRB- CBR1 -RRB- gene expression dependent on the allele status of the common polymorphic variant rs9024 .
23247010	0	carbonyl_reductase_1	20,40	CBR1	42,46	carbonyl reductase 1	CBR1	873	873	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of human carbonyl_reductase_1 -LRB- CBR1 , SDR21C1 -RRB- gene by transcription factor Nrf2 .
22614280	0	carbonyl_reductase_1	29,49	cbr1	51,55	carbonyl reductase 1	cbr1	610164(Tax:9615)	610164(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA sequence variants in the carbonyl_reductase_1 -LRB- cbr1 -RRB- gene in seven breeds of Canis_lupus_familiaris .
20806931	0	carbonyl_reductase_3	20,40	CBR3	42,46	carbonyl reductase 3	CBR3	874	874	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of human carbonyl_reductase_3 -LRB- CBR3 ; SDR21C2 -RRB- expression by Nrf2 in cultured cancer cells .
22425771	0	carbonyl_reductase_3	20,40	CBR3	42,46	carbonyl reductase 3	CBR3	874	874	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human carbonyl_reductase_3 -LRB- CBR3 ; SDR21C2 -RRB- is inducible by pro-inflammatory stimuli .
20806931	0	carbonyl_reductase_3	20,40	Nrf2	71,75	carbonyl reductase 3	Nrf2	874	4780	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of human carbonyl_reductase_3 -LRB- CBR3 ; SDR21C2 -RRB- expression by Nrf2 in cultured cancer cells .
19760265	0	carboxyl-ester_lipase	29,50	CEL	57,60	carboxyl-ester lipase	CEL	1056	1056	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the VNTR of the carboxyl-ester_lipase gene -LRB- CEL -RRB- are a rare cause of monogenic diabetes .
23395566	0	carboxyl-ester_lipase	36,57	CEL	59,62	carboxyl-ester lipase	CEL	1056	1056	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The number of tandem repeats in the carboxyl-ester_lipase -LRB- CEL -RRB- gene as a risk factor in alcoholic and idiopathic_chronic_pancreatitis .
10918051	0	carboxyl-terminal_Src_kinase	74,102	Transmembrane_phosphoprotein_Cbp	0,32	carboxyl-terminal Src kinase	Transmembrane phosphoprotein Cbp	1445	55824	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Transmembrane_phosphoprotein_Cbp positively regulates the activity of the carboxyl-terminal_Src_kinase , Csk .
7516063	0	carboxyl-terminal_src_kinase	28,56	csk	58,61	carboxyl-terminal src kinase	csk	1445	1445	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning of lsk , a carboxyl-terminal_src_kinase -LRB- csk -RRB- related gene , expressed in leukocytes .
1639390	0	carboxyl_ester_lipase	83,104	CEL	106,109	carboxyl ester lipase	CEL	1056	1056	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization , sequence analysis , and chromosomal localization of the human carboxyl_ester_lipase -LRB- CEL -RRB- gene and a CEL-like -LRB- CELL -RRB- gene .
26871237	0	carboxylesterase-1	58,76	CES1	78,82	carboxylesterase-1	CES1	1066	1066	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulatory effects of genomic translocations at the human carboxylesterase-1 -LRB- CES1 -RRB- gene locus .
19332024	0	carboxylesterase_1	14,32	CES1	34,38	carboxylesterase 1	CES1	1066	1066	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of carboxylesterase_1 -LRB- CES1 -RRB- in human adipose tissue .
19190683	0	carboxypeptidase-E	25,43	Pro-protein_convertase-2	0,24	carboxypeptidase-E	Pro-protein convertase-2	1363	5126	Gene	Gene	mediated|nsubj|START_ENTITY END_ENTITY|parataxis|mediated	Pro-protein_convertase-2 / carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia .
8314014	1	carboxypeptidase-H	46,64	glutamate_decarboxylase	85,108	carboxypeptidase-H	glutamate decarboxylase	25669(Tax:10116)	24957(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of carboxypeptidase-H and insulin but not glutamate_decarboxylase on the beta-cell surface .
12552318	0	carboxypeptidase_A4	20,39	CPA4	47,51	carboxypeptidase A4	CPA4	51200	51200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The novel imprinted carboxypeptidase_A4 gene -LRB- CPA4 -RRB- in the 7q32 imprinting domain .
19790060	0	carboxypeptidase_B	21,39	osteopontin	52,63	carboxypeptidase B	osteopontin	57094	6696	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Thrombin-activatable carboxypeptidase_B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid_arthritis .
24843127	0	carboxypeptidase_E	18,36	Insulin	0,7	carboxypeptidase E	Insulin	1363	3630	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Insulin regulates carboxypeptidase_E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic b cells .
19419578	0	carboxypeptidase_E	47,65	dopamine_transporter	14,34	carboxypeptidase E	dopamine transporter	1363	6531	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of dopamine_transporter activity by carboxypeptidase_E .
2775217	0	carboxypeptidase_H	94,112	Co2	9,12	carboxypeptidase H	Co2	1363	717	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Enhanced Co2 + activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase_H -LRB- enkephalin_convertase -RRB- .
23000409	0	carboxypeptidase_N	11,29	fibrinogen	33,43	carboxypeptidase N	fibrinogen	1369	2244	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of carboxypeptidase_N to fibrinogen and fibrin .
26340515	0	carboxypeptidase_U	17,35	CPU	37,40	carboxypeptidase U	CPU	1361	1361	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Plasma levels of carboxypeptidase_U -LRB- CPU , CPB2 or TAFIa -RRB- are elevated in patients with acute_myocardial_infarction .
21793627	0	carcinoembryonic_antigen	19,43	Alpha-fetoprotein	0,17	carcinoembryonic antigen	Alpha-fetoprotein	1084	174	Gene	Gene	population|amod|START_ENTITY population|amod|END_ENTITY	Alpha-fetoprotein , carcinoembryonic_antigen and beta2-microglobulin in adult population highly exposed to organochlorinated pollutants -LRB- PCB , DDE and HCB -RRB- .
12208761	0	carcinoembryonic_antigen	48,72	CD8	79,82	carcinoembryonic antigen	CD8	111518(Tax:10090)	925	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of an interferon-gamma-inducible carcinoembryonic_antigen -LRB- CEA -RRB- CD8 -LRB- + -RRB- T-cell epitope , which mediates tumor killing in CEA transgenic_mice .
10574697	0	carcinoembryonic_antigen	14,38	CEA	40,43	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of carcinoembryonic_antigen -LRB- CEA -RRB- N-A3 domain in Pichia_pastoris by fermentation .
10690602	0	carcinoembryonic_antigen	9,33	CEA	35,38	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Elevated carcinoembryonic_antigen -LRB- CEA -RRB- levels in a patient with no malignancy .
11273768	0	carcinoembryonic_antigen	37,61	CEA	63,66	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Augmenting transgene expression from carcinoembryonic_antigen -LRB- CEA -RRB- promoter via a GAL4 gene regulatory system .
11712806	0	carcinoembryonic_antigen	20,44	CEA	46,49	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of carcinoembryonic_antigen -LRB- CEA -RRB- in tumor tissue of patients with colorectal_cancer .
11939491	0	carcinoembryonic_antigen	31,55	CEA	57,60	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Intermethod variation in serum carcinoembryonic_antigen -LRB- CEA -RRB- measurement .
11964079	0	carcinoembryonic_antigen	25,49	CEA	51,54	carcinoembryonic antigen	CEA	111518(Tax:10090)	111518(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of endogenous carcinoembryonic_antigen -LRB- CEA -RRB- increases the apoptotic rate of colon_cancer cells and inhibits metastatic_tumor growth .
1260660	1	carcinoembryonic_antigen	30,54	CEA	56,59	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Abnormal carcinoembryonic_antigen -LRB- CEA -RRB- levels in asymptomatic retinoblastoma family members .
1327687	0	carcinoembryonic_antigen	26,50	CEA	52,55	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- The relationship between carcinoembryonic_antigen -LRB- CEA -RRB- expression and histogenesis of gastric_cancer -LRB- application of immunohistochemical and mucin histochemical techniques -RRB- -RSB- .
1546571	0	carcinoembryonic_antigen	84,108	CEA	110,113	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	level|compound|START_ENTITY level|appos|END_ENTITY	-LSB- A case of transitional_cell_carcinoma of renal pelvis with an extremely high serum carcinoembryonic_antigen -LRB- CEA -RRB- level -RSB- .
1567173	0	carcinoembryonic_antigen	32,56	CEA	58,61	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Serum sialic_acid -LRB- TSA/LSA -RRB- and carcinoembryonic_antigen -LRB- CEA -RRB- levels in cancer patients undergoing radiotherapy .
1625062	0	carcinoembryonic_antigen	25,49	CEA	51,54	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Membranous expression of carcinoembryonic_antigen -LRB- CEA -RRB- in the normal cervical squamous_mucosa .
18604735	0	carcinoembryonic_antigen	29,53	CEA	55,58	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Protein expression levels of carcinoembryonic_antigen -LRB- CEA -RRB- in Danish ovarian_cancer patients : from the Danish _ ` MALOVA'ovarian _ cancer study .
18630484	0	carcinoembryonic_antigen	35,59	CEA	61,64	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	Diminishing impact of preoperative carcinoembryonic_antigen -LRB- CEA -RRB- in prognosis of Dukes ' C colorectal_cancer .
19068780	0	carcinoembryonic_antigen	57,81	CEA	83,86	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Recurrence pattern and rapid intraoperative detection of carcinoembryonic_antigen -LRB- CEA -RRB- mRNA in pleural_lavage in patients with non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
2065318	0	carcinoembryonic_antigen	35,59	CEA	66,69	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regional chromosomal assignment of carcinoembryonic_antigen gene -LRB- CEA -RRB- to chromosome 19 at band q13 .2 .
2133556	0	carcinoembryonic_antigen	36,60	CEA	62,65	carcinoembryonic antigen	CEA	111518(Tax:10090)	111518(Tax:10090)	Gene	Gene	members|amod|START_ENTITY members|appos|END_ENTITY	Spatiotemporal expression of murine carcinoembryonic_antigen -LRB- CEA -RRB- gene family members during mouse embryogenesis .
25697175	0	carcinoembryonic_antigen	16,40	CEA	42,45	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of carcinoembryonic_antigen -LRB- CEA -RRB- in patients with bipolar_disorder .
2685416	0	carcinoembryonic_antigen	10,34	CEA	36,39	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Study|nmod|START_ENTITY Study|appos|END_ENTITY	-LSB- Study of carcinoembryonic_antigen -LRB- CEA -RRB- in the epidermis of psoriasis_vulgaris -RSB- .
2845551	0	carcinoembryonic_antigen	29,53	CEA	55,58	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of carcinoembryonic_antigen -LRB- CEA -RRB- in lung_carcinoma by five monoclonal antibodies .
3026253	0	carcinoembryonic_antigen	94,118	CEA	120,123	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Serum neuron-specific_enolase -LRB- NSE -RRB- in patients with small cell lung_cancer -- comparison with carcinoembryonic_antigen -LRB- CEA -RRB- -RSB- .
3046676	0	carcinoembryonic_antigen	34,58	CEA	60,63	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Immunohistochemical study of the carcinoembryonic_antigen -LRB- CEA -RRB- in human tumors using the CEA-specific oncoprecipitin crustacin -RSB- .
3397719	0	carcinoembryonic_antigen	16,40	CEA	42,45	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	-LSB- Correlation of carcinoembryonic_antigen -LRB- CEA -RRB- content in resected tissue with serum CEA levels in patients with gastric_carcinoma -RSB- .
3513695	0	carcinoembryonic_antigen	32,56	CEA	58,61	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of carcinoembryonic_antigen -LRB- CEA -RRB- on ultrathin cryosections of human tumours .
3522636	0	carcinoembryonic_antigen	17,41	CEA	43,46	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Demonstration of carcinoembryonic_antigen -LRB- CEA -RRB- expression in normal , chronically inflamed , and malignant pancreatic tissue by immunohistochemistry .
3681244	0	carcinoembryonic_antigen	16,40	CEA	42,45	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	-LSB- Correlation of carcinoembryonic_antigen -LRB- CEA -RRB- content in the resected tissue with the serum CEA levels in patients with colorectal_carcinoma -RSB- .
4057566	0	carcinoembryonic_antigen	40,64	CEA	66,69	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	-LSB- Evaluation of the measurement of serum carcinoembryonic_antigen -LRB- CEA -RRB- levels using monoclonal antibody -RSB- .
498010	0	carcinoembryonic_antigen	20,44	CEA	46,49	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The value of serial carcinoembryonic_antigen -LRB- CEA -RRB- in predicting response rate and survival of patients with gastrointestinal_cancer treated with chemotherapy .
6262678	0	carcinoembryonic_antigen	14,38	CEA	40,43	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Assay|nmod|START_ENTITY Assay|appos|END_ENTITY	-LSB- Assay of the carcinoembryonic_antigen -LRB- CEA -RRB- in acute and chronic liver_diseases and hepatocellular_carcinoma -RSB- .
6296267	0	carcinoembryonic_antigen	11,35	CEA	37,40	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of carcinoembryonic_antigen -LRB- CEA -RRB- to an anti-CEA immunosorbent in the presence of detergents .
6446377	0	carcinoembryonic_antigen	41,65	CEA	67,70	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	The use and limitations of serial plasma carcinoembryonic_antigen -LRB- CEA -RRB- levels as a monitor of changing metastatic liver_tumor volume in patients receiving chemotherapy .
6506227	0	carcinoembryonic_antigen	20,44	CEA	46,49	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Diagnostic value of carcinoembryonic_antigen -LRB- CEA -RRB- assay in pleural_effusions .
6537552	0	carcinoembryonic_antigen	16,40	CEA	42,45	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- High levels of carcinoembryonic_antigen -LRB- CEA -RRB- in the serum of uremic patients under hemodialysis treatment -RSB- .
6839982	0	carcinoembryonic_antigen	22,46	CEA	48,51	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of the carcinoembryonic_antigen -LRB- CEA -RRB- for predicting the success of therapy in metastatic breast_cancer -RSB- .
7021564	0	carcinoembryonic_antigen	12,36	CEA	38,41	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of carcinoembryonic_antigen -LRB- CEA -RRB- in the normal and inflamed human parotid gland .
7148317	0	carcinoembryonic_antigen	25,49	CEA	51,54	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of carcinoembryonic_antigen -LRB- CEA -RRB- in patients with adenocarcinoma in colon_and_rectum .
7357243	0	carcinoembryonic_antigen	59,83	CEA	85,88	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	The clinical significance of the pattern of elevated serum carcinoembryonic_antigen -LRB- CEA -RRB- levels in recurrent colorectal_cancer .
7426321	0	carcinoembryonic_antigen	31,55	CEA	57,60	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The diagnostic value of plasma carcinoembryonic_antigen -LRB- CEA -RRB- in pancreatic_disease .
7460983	0	carcinoembryonic_antigen	41,65	CEA	67,70	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The clinical value of plasma and urinary carcinoembryonic_antigen -LRB- CEA -RRB- assays in patients with haematuria and urothelial_carcinoma .
81670	0	carcinoembryonic_antigen	49,73	CEA	75,78	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Physicochemical and immunochemical properties of carcinoembryonic_antigen -LRB- CEA -RRB- from different tumour sources .
817166	0	carcinoembryonic_antigen	18,42	CEA	44,47	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of carcinoembryonic_antigen -LRB- CEA -RRB- in patients with tumors of the large intestine .
837050	0	carcinoembryonic_antigen	37,61	CEA	63,66	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The clinical diagnostic value of the carcinoembryonic_antigen -LRB- CEA -RRB- in haematuria .
8689623	0	carcinoembryonic_antigen	63,87	CEA	89,92	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A colorimetric immunoassay for the detection of E-cadherin and carcinoembryonic_antigen -LRB- CEA -RRB- expression on human colon_carcinoma cell lines in vitro .
8919110	0	carcinoembryonic_antigen	36,60	CEA	62,65	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	localisation|nmod|START_ENTITY localisation|appos|END_ENTITY	Immunohistochemical localisation of carcinoembryonic_antigen -LRB- CEA -RRB- in malignant_epithelial_ovarian_tumours using monoclonal antibodies .
947865	0	carcinoembryonic_antigen	10,34	CEA	36,39	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	-LSB- Value of carcinoembryonic_antigen -LRB- CEA -RRB- in the diagnosis of malignant_tumors of the urogenital tract -RSB- .
9673116	0	carcinoembryonic_antigen	19,43	CEA	45,48	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	-LSB- The evaluation of carcinoembryonic_antigen -LRB- CEA -RRB- levels in patients with laryngeal_cancer -RSB- .
9832303	0	carcinoembryonic_antigen	46,70	CEA	72,75	carcinoembryonic antigen	CEA	1084	1084	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Solid-phase synthesis and characterization of carcinoembryonic_antigen -LRB- CEA -RRB- domains .
7780031	0	carcinoembryonic_antigen	45,69	IL-6	23,27	carcinoembryonic antigen	IL-6	1084	3569	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Synergistic effects of IL-6 and IFN-gamma on carcinoembryonic_antigen -LRB- CEA -RRB- and HLA expression by human colorectal_carcinoma cells : role for endogenous IFN-beta .
10761792	0	carcinoembryonic_antigen	57,81	Interleukin-6	0,13	carcinoembryonic antigen	Interleukin-6	1084	3569	Gene	Gene	circulating|dobj|START_ENTITY associated|advcl|circulating associated|nsubjpass|level level|amod|END_ENTITY	Interleukin-6 blood level is associated with circulating carcinoembryonic_antigen and prognosis in patients with colorectal_cancer .
1477074	0	carcinoembryonic_antigen	24,48	Interleukin-6	0,13	carcinoembryonic antigen	Interleukin-6	1084	3569	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-6 increases carcinoembryonic_antigen and histocompatibility leukocyte antigen expression on the surface of human colorectal_carcinoma cells .
2933260	0	carcinoembryonic_antigen	143,167	beta-N-acetyl_hexosaminidase	6,34	carcinoembryonic antigen	beta-N-acetyl hexosaminidase	1084	284004	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Serum beta-N-acetyl_hexosaminidase -LRB- beta-NAH -RRB- as a discriminant between malignant and benign extrahepatic_biliary_obstruction : comparison with carcinoembryonic_antigen -LRB- CEA -RRB- .
1998947	0	carcinoembryonic_antigen	156,180	biliary_glycoprotein	118,138	carcinoembryonic antigen	biliary glycoprotein	1084	634	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Identification of membrane antigens in granulocytes and colonic_carcinoma cells by a monoclonal antibody specific for biliary_glycoprotein , a member of the carcinoembryonic_antigen family .
21597777	0	carcinoembryonic_antigen	46,70	cea	72,75	carcinoembryonic antigen	cea	1084	1084	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Tissue polypeptide antigen-specific -LRB- tps -RRB- and carcinoembryonic_antigen -LRB- cea -RRB- levels in cancerous and precancerous_lesions in human colon .
9395467	0	carcinoembryonic_antigen	52,76	cea5	0,4	carcinoembryonic antigen	cea5	111518(Tax:10090)	26368(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	cea5 , a structurally divergent member of the murine carcinoembryonic_antigen gene family , is exclusively expressed during early placental development in trophoblast giant cells .
25232379	0	carcinoembryonic_antigen	84,108	miR-148b	0,8	carcinoembryonic antigen	miR-148b	1084	442892	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	miR-148b functions as a tumor suppressor in non-small_cell_lung_cancer by targeting carcinoembryonic_antigen -LRB- CEA -RRB- .
17446847	0	carcinoembryonic_antigen	13,37	mucin	58,63	carcinoembryonic antigen	mucin	1084	100508689	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	The level of carcinoembryonic_antigen and the presence of mucin as predictors of cystic pancreatic mucinous_neoplasia .
3337731	0	carcinoembryonic_antigen	74,98	nonspecific_crossreacting_antigen	21,54	carcinoembryonic antigen	nonspecific crossreacting antigen	1084	1084	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Primary structure of nonspecific_crossreacting_antigen -LRB- NCA -RRB- , a member of carcinoembryonic_antigen -LRB- CEA -RRB- gene family , deduced from cDNA sequence .
23554611	0	carcinoembryonic_antigen	17,41	p53	43,46	carcinoembryonic antigen	p53	1084	7157	Gene	Gene	Ki-67|compound|START_ENTITY Ki-67|dep|END_ENTITY	The potential of carcinoembryonic_antigen , p53 , Ki-67 and glutathion Stransferase - as clinico-histopathological markers for colorectal_cancer .
3042807	0	carcinoembryonic_antigen	11,35	phosphatidylinositol-specific_phospholipase_C	69,114	carcinoembryonic antigen	phosphatidylinositol-specific phospholipase C	1084	23236	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of carcinoembryonic_antigen from human colon_cancer cells by phosphatidylinositol-specific_phospholipase_C .
8215392	0	carcinoembryonic_antigen	11,35	phosphatidylinositol-specific_phospholipase_C	62,107	carcinoembryonic antigen	phosphatidylinositol-specific phospholipase C	1084	23236	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Release of carcinoembryonic_antigen from human tumor cells by phosphatidylinositol-specific_phospholipase_C : highly effective extraction and upregulation from LS-174T colonic_adenocarcinoma cells .
2334536	0	carcinoembryonic_antigen	13,37	transforming_growth_factor-beta	118,149	carcinoembryonic antigen	transforming growth factor-beta	1084	7040	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of carcinoembryonic_antigen and its crossreactive gene products in human colonic_adenomas and carcinomas by transforming_growth_factor-beta .
3289738	0	carcinoembryonic_antigen	13,37	transforming_growth_factor-beta	164,195	carcinoembryonic antigen	transforming growth factor-beta	1084	7040	Gene	Gene	secretion|compound|START_ENTITY Induction|nmod|secretion Induction|nmod|END_ENTITY	Induction of carcinoembryonic_antigen secretion and modulation of protein secretion/expression and fibronectin/laminin expression in human colon_carcinoma cells by transforming_growth_factor-beta .
1380512	0	carcinoembryonic_antigen	75,99	transforming_growth_factor-beta_1	28,61	carcinoembryonic antigen	transforming growth factor-beta 1	1084	7040	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Role of protein_kinase_C in transforming_growth_factor-beta_1 induction of carcinoembryonic_antigen in human colon_carcinoma cells .
21398516	0	carcinoembryonic_antigen-related_cell_adhesion_molecule-1	23,80	CEACAM1	82,89	carcinoembryonic antigen-related cell adhesion molecule-1	CEACAM1	634	634	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Mechanistic control of carcinoembryonic_antigen-related_cell_adhesion_molecule-1 -LRB- CEACAM1 -RRB- splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L , hnRNP_A1 , and hnRNP_M .
22962327	0	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	42,99	CD11b	114,119	carcinoembryonic antigen-related cell adhesion molecule 1	CD11b	26365(Tax:10090)	16409(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Acceleration of collateral development by carcinoembryonic_antigen-related_cell_adhesion_molecule_1 expression on CD11b / Gr-1 myeloid cells -- brief report .
21669871	0	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	26,83	CEACAM1	85,92	carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	634	634	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Interaction of actin with carcinoembryonic_antigen-related_cell_adhesion_molecule_1 -LRB- CEACAM1 -RRB- receptor in liposomes is Ca2 + - and phospholipid-dependent .
16619040	0	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	16,73	Ceacam1	75,82	carcinoembryonic antigen-related cell adhesion molecule 1	Ceacam1	26365(Tax:10090)	26365(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion of the carcinoembryonic_antigen-related_cell_adhesion_molecule_1 -LRB- Ceacam1 -RRB- gene contributes to colon_tumor progression in a murine model of carcinogenesis .
26301891	0	carcinoembryonic_antigen-related_cell_adhesion_molecule_1	36,93	MITF	0,4	carcinoembryonic antigen-related cell adhesion molecule 1	MITF	634	4286	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MITF is a critical regulator of the carcinoembryonic_antigen-related_cell_adhesion_molecule_1 -LRB- CEACAM1 -RRB- in malignant_melanoma .
18694378	0	carcinoma	13,22	NF-kappaB	0,9	NF-kappaB	NF-kappaB	4790	4790	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	NF-kappaB in carcinoma therapy and prevention .
10579051	0	cardiac_calsequestrin	64,85	GATA-4	14,20	cardiac calsequestrin	GATA-4	12373(Tax:10090)	14463(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of GATA-4 and AP-1 in transgenic_mice overexpressing cardiac_calsequestrin .
18624753	0	cardiac_lineage_protein	19,42	CLP-1	44,49	cardiac lineage protein	CLP-1	98985(Tax:10090)	98985(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Down-regulation of cardiac_lineage_protein -LRB- CLP-1 -RRB- expression in CLP-1 + / - mice affords .
25982880	0	cardiac_myosin_light_chain_2	8,36	NADPH_oxidase_2	47,62	cardiac myosin light chain 2	NADPH oxidase 2	363925(Tax:10116)	66021(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Nuclear cardiac_myosin_light_chain_2 modulates NADPH_oxidase_2 expression in myocardium : a novel function beyond muscle contraction .
25982880	0	cardiac_myosin_light_chain_2	8,36	NADPH_oxidase_2	47,62	cardiac myosin light chain 2	NADPH oxidase 2	363925(Tax:10116)	66021(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|amod|END_ENTITY	Nuclear cardiac_myosin_light_chain_2 modulates NADPH_oxidase_2 expression in myocardium : a novel function beyond muscle contraction .
9929748	0	cardiac_troponin-I	12,30	cTnI	32,36	cardiac troponin-I	cTnI	7137	7137	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of cardiac_troponin-I -LRB- cTnI -RRB- in risk stratification of patients with unstable coronary_artery_disease .
26165658	0	cardiac_troponin-T	30,48	cTnT	50,54	cardiac troponin-T	cTnT	7139	7139	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	The effect of elapsed time on cardiac_troponin-T -LRB- cTnT -RRB- degradation and its relation to postmortem interval in cases of electrocution .
26971187	0	cardiac_troponin-T	30,48	cTnT	50,54	cardiac troponin-T	cTnT	7139	7139	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	The effect of elapsed time on cardiac_troponin-T -LRB- cTnT -RRB- degradation and its dependency on the cause of death .
9065755	0	cardiac_troponin_I	22,40	GATA-4	74,80	cardiac troponin I	GATA-4	29248(Tax:10116)	54254(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the rat cardiac_troponin_I gene by the transcription factor GATA-4 .
25185555	0	cardiac_troponin_I	23,41	PKA	0,3	cardiac troponin I	PKA	29248(Tax:10116)	25636(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	PKA phosphorylation of cardiac_troponin_I modulates activation and relaxation kinetics of ventricular myofibrils .
10178711	0	cardiac_troponin_I	22,40	cardiac_troponin_I	96,114	cardiac troponin I	cardiac troponin I	7137	7137	Gene	Gene	START_ENTITY|dep|use use|nmod|END_ENTITY	Cost-effectiveness of cardiac_troponin_I in a systematic chest_pain evaluation protocol : use of cardiac_troponin_I lowers length of stay for low-risk cardiac patients .
10178711	0	cardiac_troponin_I	96,114	cardiac_troponin_I	22,40	cardiac troponin I	cardiac troponin I	7137	7137	Gene	Gene	use|nmod|START_ENTITY END_ENTITY|dep|use	Cost-effectiveness of cardiac_troponin_I in a systematic chest_pain evaluation protocol : use of cardiac_troponin_I lowers length of stay for low-risk cardiac patients .
15840586	0	cardiac_troponin_I	114,132	p90RSK	33,39	cardiac troponin I	p90RSK	21954(Tax:10090)	20112(Tax:10090)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of p90_ribosomal_S6_kinase -LRB- p90RSK -RRB- in reactive oxygen species and protein_kinase_C_beta -LRB- PKC-beta -RRB- - mediated cardiac_troponin_I phosphorylation .
12454230	0	cardiac_troponin_T	9,27	CRP	79,82	cardiac troponin T	CRP	7139	1401	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Elevated cardiac_troponin_T in peritoneal_dialysis patients is associated with CRP and predicts all-cause mortality and cardiac_death .
22099949	0	cardiac_troponin_T	26,44	FGF-23	0,6	cardiac troponin T	FGF-23	7139	8074	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	FGF-23 is associated with cardiac_troponin_T and mortality in hemodialysis patients .
23778016	0	cardiomyopathy-associated_5	50,77	CMYA5	43,48	cardiomyopathy-associated 5	CMYA5	202333	202333	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Genetic analysis of common variants in the CMYA5 -LRB- cardiomyopathy-associated_5 -RRB- gene with schizophrenia .
11360260	0	cardiotrophin-1	11,26	CT-1	28,32	cardiotrophin-1	CT-1	13019(Tax:10090)	13019(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of cardiotrophin-1 -LRB- CT-1 -RRB- in a mouse motor_neuron_disease .
14597603	0	cardiotrophin-1	26,41	CT-1	43,47	cardiotrophin-1	CT-1	1489	1489	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and effects of cardiotrophin-1 -LRB- CT-1 -RRB- in human airway smooth muscle cells .
17081402	0	cardiotrophin-1	11,26	GATA4	59,64	cardiotrophin-1	GATA4	29201(Tax:10116)	54254(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- Effect of cardiotrophin-1 on cardiac transcription factor GATA4 expression in rat cardiomyocytes -RSB- .
11013126	0	cardiotrophin-1	24,39	gp130	68,73	cardiotrophin-1	gp130	29201(Tax:10116)	25205(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Augmented expression of cardiotrophin-1 and its receptor component , gp130 , in both left and right ventricles after myocardial_infarction in the rat .
11304496	0	cardiotrophin-1	129,144	gp130	67,72	cardiotrophin-1	gp130	29201(Tax:10116)	25205(Tax:10116)	Gene	Gene	treated|nmod|START_ENTITY rat|acl|treated involved|nmod|rat involved|nmod|resistance resistance|amod|END_ENTITY	Induction of JAB/SOCS -1 / SSI-1 and CIS3/SOCS -3 / SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo .
9325015	0	cardiotrophin_1	42,57	interleukin_6	14,27	cardiotrophin 1	interleukin 6	1489	3569	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of interleukin_6 expression by cardiotrophin_1 .
24088670	0	carnitine-acylcarnitine_translocase	29,64	CACT	66,70	carnitine-acylcarnitine translocase	CACT	788	788	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Three novel mutations in the carnitine-acylcarnitine_translocase -LRB- CACT -RRB- gene in patients with CACT_deficiency and in healthy individuals .
19577614	0	carnitine-acylcarnitine_translocase	6,41	PPARalpha	83,92	carnitine-acylcarnitine translocase	PPARalpha	57279(Tax:10090)	19013(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Mouse carnitine-acylcarnitine_translocase -LRB- CACT -RRB- is transcriptionally regulated by PPARalpha and PPARdelta in liver cells .
16919490	0	carnitine-acylcarnitine_translocase	97,132	SLC25A20	8,16	carnitine-acylcarnitine translocase	SLC25A20	788	788	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	A novel SLC25A20 splicing mutation in patients of different ethnic origin with neonatally lethal carnitine-acylcarnitine_translocase -LRB- CACT -RRB- deficiency .
18839069	0	carnitine_acetyltransferase	4,31	CRAT	38,42	carnitine acetyltransferase	CRAT	1384	1384	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The carnitine_acetyltransferase gene -LRB- CRAT -RRB- : a characterization of porcine transcripts with insights into the 5 ' - end variants of mammalian transcripts and their possible sub-cellular localization .
9845345	0	carnitine_palmitoyltransferase_I	68,100	AMP-activated_protein_kinase	18,46	carnitine palmitoyltransferase I	AMP-activated protein kinase	25756(Tax:10116)	78975(Tax:10116)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Evidence that the AMP-activated_protein_kinase stimulates rat liver carnitine_palmitoyltransferase_I by phosphorylating cytoskeletal components .
17089095	0	carnitine_palmitoyltransferase_I	53,85	CPT1	87,91	carnitine palmitoyltransferase I	CPT1	1374	1374	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants within the muscle and liver isoforms of the carnitine_palmitoyltransferase_I -LRB- CPT1 -RRB- gene interact with fat intake to modulate indices of obesity in French-Canadians .
18521119	0	carnitine_palmitoyltransferase_I	131,163	CPT_I	165,170	carnitine palmitoyltransferase I	CPT I	36109(Tax:7227)	36109(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations of the withered -LRB- whd -RRB- gene in Drosophila_melanogaster confer hypersensitivity_to_oxidative_stress and are lesions of the carnitine_palmitoyltransferase_I -LRB- CPT_I -RRB- gene .
23705015	0	carnosine_N-methyltransferase	28,57	histamine_N-methyltransferase-like	69,103	carnosine N-methyltransferase	histamine N-methyltransferase-like	771456(Tax:9031)	771456(Tax:9031)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Molecular identification of carnosine_N-methyltransferase as chicken histamine_N-methyltransferase-like protein -LRB- hnmt-like -RRB- .
20383744	0	carotene_beta_hydroxylase_2	27,54	CrtR-b2	18,25	carotene beta hydroxylase 2	CrtR-b2	544297(Tax:4081)	544297(Tax:4081)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of CrtR-b2 -LRB- carotene_beta_hydroxylase_2 -RRB- from S. _ lycopersicum_L .
12121354	0	cartilage-derived_morphogenetic_protein-1	16,57	CDMP1	59,64	cartilage-derived morphogenetic protein-1	CDMP1	8200	8200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation in the cartilage-derived_morphogenetic_protein-1 -LRB- CDMP1 -RRB- gene in a kindred affected with fibular_hypoplasia and complex brachydactyly -LRB- DuPan_syndrome -RRB- .
19038017	0	cartilage-derived_morphogenetic_protein-1	34,75	CDMP1	77,82	cartilage-derived morphogenetic protein-1	CDMP1	8200	8200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel insertion mutation in the cartilage-derived_morphogenetic_protein-1 -LRB- CDMP1 -RRB- gene underlies Grebe-type_chondrodysplasia in a consanguineous Pakistani family .
12124730	0	cartilage-derived_morphogenetic_protein_1	27,68	CDMP1	70,75	cartilage-derived morphogenetic protein 1	CDMP1	8200	8200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frameshift mutation in the cartilage-derived_morphogenetic_protein_1 -LRB- CDMP1 -RRB- gene and severe acromesomelic_chondrodysplasia resembling Grebe-type_chondrodysplasia .
12358374	0	cartilage-derived_retinoic-acid-sensitive_protein	12,61	CD-RAP	63,69	cartilage-derived retinoic-acid-sensitive protein	CD-RAP	8190	8190	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of cartilage-derived_retinoic-acid-sensitive_protein -LRB- CD-RAP -RRB- in synovial fluid from patients with osteoarthritis and rheumatoid_arthritis .
9478951	0	cartilage-derived_retinoic_acid-sensitive_protein	24,73	AP-2	107,111	cartilage-derived retinoic acid-sensitive protein	AP-2	12587(Tax:10090)	21418(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the mouse cartilage-derived_retinoic_acid-sensitive_protein gene by the transcription factor AP-2 .
11918321	0	cartilage-derived_retinoic_acid-sensitive_protein	6,55	CD-RAP	57,63	cartilage-derived retinoic acid-sensitive protein	CD-RAP	81510(Tax:10116)	81510(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum cartilage-derived_retinoic_acid-sensitive_protein -LRB- CD-RAP -RRB- levels in swarm rat chondrosarcoma .
22123310	0	cartilage-derived_retinoic_acid-sensitive_protein	32,81	CD-RAP	83,89	cartilage-derived retinoic acid-sensitive protein	CD-RAP	12587(Tax:10090)	12587(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of cartilage-derived_retinoic_acid-sensitive_protein -LRB- CD-RAP -RRB- / melanoma_inhibitory_activity -LRB- MIA -RRB- in murine , canine , bovine and equine cerebrospinal tissues .
8034306	0	cartilage-hair_hypoplasia	39,64	CHH	66,69	cartilage-hair hypoplasia	CHH	6023	6023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High-resolution genetic mapping of the cartilage-hair_hypoplasia -LRB- CHH -RRB- gene in Amish and Finnish families .
14608646	0	cartilage-hair_hypoplasia	41,66	RMRP	0,4	cartilage-hair hypoplasia	RMRP	6023	6023	Gene	Gene	mutations|nmod|START_ENTITY mutations|nsubj|END_ENTITY	RMRP mutations in Japanese patients with cartilage-hair_hypoplasia .
24730590	0	cartilage_glycoprotein_39	42,67	CD4	71,74	cartilage glycoprotein 39	CD4	1116	920	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Antigen-specific over-expression of human cartilage_glycoprotein_39 on CD4 + CD25 + forkhead_box_protein_3 + regulatory T cells in the generation of glucose-6-phosphate_isomerase-induced arthritis .
16413503	0	cartilage_intermediate_layer_protein	34,70	CILP	72,76	cartilage intermediate layer protein	CILP	8483	8483	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the cartilage_intermediate_layer_protein -LRB- CILP -RRB- gene .
10343777	0	cartilage_oligomeric_matrix_protein	14,49	COMP	51,55	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- by cultured human dermal and synovial fibroblasts .
11501943	0	cartilage_oligomeric_matrix_protein	54,89	COMP	48,52	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification of sequence polymorphisms of the COMP -LRB- cartilage_oligomeric_matrix_protein -RRB- gene and association study in osteoarthrosis of the knee and hip_joints .
11531396	0	cartilage_oligomeric_matrix_protein	20,55	COMP	57,61	cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in equine carpal articular cartilage and its variation with exercise_and_cartilage_deterioration .
12202123	0	cartilage_oligomeric_matrix_protein	16,51	COMP	53,57	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- correlate with radiographic progression of knee_osteoarthritis .
12405694	0	cartilage_oligomeric_matrix_protein	15,50	COMP	52,56	cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Correlation of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- levels in equine tendon with mechanical properties : a proposed role for COMP in determining function-specific mechanical characteristics of locomotor tendons .
12792737	0	cartilage_oligomeric_matrix_protein	23,58	COMP	60,64	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations of the cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- gene in two Japanese patients with pseudoachondroplasia .
15607888	0	cartilage_oligomeric_matrix_protein	32,67	COMP	26,30	cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	Enhanced concentration of COMP -LRB- cartilage_oligomeric_matrix_protein -RRB- in osteochondral_fractures from racing Thoroughbreds .
15639635	0	cartilage_oligomeric_matrix_protein	23,58	COMP	60,64	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	Serum concentration of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- is sensitive to physiological cyclic loading in healthy adults .
16005620	0	cartilage_oligomeric_matrix_protein	38,73	COMP	75,79	cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	immunolocalization|nmod|START_ENTITY immunolocalization|appos|END_ENTITY	Ultrastructural immunolocalization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in relation to collagen fibrils in the equine tendon .
17156423	0	cartilage_oligomeric_matrix_protein	16,51	COMP	53,57	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- increase temporarily after physical exercise in patients with knee_osteoarthritis .
17657676	0	cartilage_oligomeric_matrix_protein	6,41	COMP	43,47	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- levels in knee_osteoarthritis in a Brazilian population : clinical and radiological correlation .
18840965	0	cartilage_oligomeric_matrix_protein	12,47	COMP	49,53	cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in synovial fluid , serum and urine from 51 racehorses with carpal_bone_fracture .
19237461	0	cartilage_oligomeric_matrix_protein	52,87	COMP	89,93	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	reduction|nmod|START_ENTITY reduction|appos|END_ENTITY	Ribozyme-mediated reduction of wild-type and mutant cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- mRNA and protein .
19716571	0	cartilage_oligomeric_matrix_protein	38,73	COMP	75,79	cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	immunolocalization|nmod|START_ENTITY immunolocalization|appos|END_ENTITY	Ultrastructural immunolocalization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in the articular cartilage on the equine third carpal bone in trained and untrained horses .
25489544	0	cartilage_oligomeric_matrix_protein	41,76	COMP	78,82	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Thyroid hormones increase collagen I and cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- expression in vitro human tenocytes .
8311563	0	cartilage_oligomeric_matrix_protein	11,46	COMP	48,52	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- into joint fluid after knee_injury and in osteoarthritis .
9164830	0	cartilage_oligomeric_matrix_protein	38,73	COMP	75,79	cartilage oligomeric matrix protein	COMP	281088(Tax:9913)	281088(Tax:9913)	Gene	Gene	immunolocalization|nmod|START_ENTITY immunolocalization|appos|END_ENTITY	Ultrastructural immunolocalization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in porcine growth cartilage .
9501326	0	cartilage_oligomeric_matrix_protein	20,55	COMP	57,61	cartilage oligomeric matrix protein	COMP	100033911(Tax:9796)	100033911(Tax:9796)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in tendon and its variation with tendon site , age and load .
9714346	0	cartilage_oligomeric_matrix_protein	12,47	COMP	49,53	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in synovial fibroblasts and synovial fluids .
9749943	0	cartilage_oligomeric_matrix_protein	20,55	COMP	57,61	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- in human normal and pseudoachondroplasia musculoskeletal tissues .
9887340	0	cartilage_oligomeric_matrix_protein	41,76	COMP	78,82	cartilage oligomeric matrix protein	COMP	1311	1311	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Trinucleotide expansion mutations in the cartilage_oligomeric_matrix_protein -LRB- COMP -RRB- gene .
18485748	0	cartilage_oligomeric_matrix_protein	52,87	alpha-2-macroglobulin	91,112	cartilage oligomeric matrix protein	alpha-2-macroglobulin	1311	2	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage_oligomeric_matrix_protein by alpha-2-macroglobulin .
15337766	0	cartilage_oligomeric_matrix_protein	135,170	histone_deacetylase-1	100,121	cartilage oligomeric matrix protein	histone deacetylase-1	12845(Tax:10090)	433759(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Leukemia/lymphoma-related _ factor , a POZ domain-containing transcriptional repressor , interacts with histone_deacetylase-1 and inhibits cartilage_oligomeric_matrix_protein gene expression and chondrogenesis .
17033713	0	cartilage_oligomeric_matrix_protein	17,52	insulin-like_growth_factor-I	72,100	cartilage oligomeric matrix protein	insulin-like growth factor-I	1311	3479	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of cartilage_oligomeric_matrix_protein gene expression by insulin-like_growth_factor-I revealed by real-time reverse transcription-polymerase chain reaction .
1860834	0	cartilage_procollagen_gene	22,48	COL2A1	50,56	cartilage procollagen gene	COL2A1	1280	1280	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of a human cartilage_procollagen_gene -LRB- COL2A1 -RRB- in mouse 3T3 cells .
18752583	0	casein	27,33	CSN3	35,39	casein	CSN3	100033983(Tax:9796)	100033983(Tax:9796)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the kappa casein -LRB- CSN3 -RRB- gene in horse and comparative analysis of its promoter and coding region .
19285963	0	casein_kinase-1	18,33	TDP-43	59,65	casein kinase-1	TDP-43	122011	23435	Gene	Gene	sites|amod|START_ENTITY Identification|nmod|sites Identification|nmod|END_ENTITY	Identification of casein_kinase-1 phosphorylation sites on TDP-43 .
22113361	0	casein_kinase_1	20,35	CK1	39,42	casein kinase 1	CK1	122011	122011	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association of a casein_kinase_1 -LRB- CK1 -RRB- gene polymorphism with personality traits in healthy Chinese-Han subjects .
23413191	0	casein_kinase_1	45,60	DDX3	13,17	casein kinase 1	DDX3	122011	1654	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	RNA helicase DDX3 is a regulatory subunit of casein_kinase_1 in Wnt-b-catenin signaling .
21233202	0	casein_kinase_1	54,69	ribosomal_protein_S6	14,34	casein kinase 1	ribosomal protein S6	122011	6194	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Regulation of ribosomal_protein_S6 phosphorylation by casein_kinase_1 and protein phosphatase 1 .
15961172	0	casein_kinase_1_delta	15,36	CK1_delta	38,47	casein kinase 1 delta	CK1 delta	1453	1453	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of casein_kinase_1_delta -LRB- CK1_delta -RRB- with the light chain LC2 of microtubule_associated_protein_1A -LRB- MAP1A -RRB- .
26206296	0	casein_kinase_1_delta	62,83	CK1d	85,89	casein kinase 1 delta	CK1d	1453	1453	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Computer-aided scaffold hopping to identify a novel series of casein_kinase_1_delta -LRB- CK1d -RRB- inhibitors for amyotrophic_lateral_sclerosis .
10826492	0	casein_kinase_1_delta	15,36	CK1delta	38,46	casein kinase 1 delta	CK1delta	1453	1453	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of casein_kinase_1_delta -LRB- CK1delta -RRB- with post-Golgi structures , microtubules and the spindle apparatus .
12138108	0	casein_kinase_2	24,39	FCP1	0,4	casein kinase 2	FCP1	399320(Tax:8355)	398018(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	FCP1 phosphorylation by casein_kinase_2 enhances binding to TFIIF and RNA polymerase II carboxyl-terminal domain phosphatase activity .
24105464	0	casein_kinase_I	26,41	TDP-43	0,6	casein kinase I	TDP-43	32221(Tax:7227)	37781(Tax:7227)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	TDP-43 Phosphorylation by casein_kinase_I promotes oligomerization and enhances toxicity in vivo .
9834084	0	casein_kinase_II	86,102	CD5	6,9	casein kinase II	CD5	1457	921	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Human CD5 signaling and constitutive phosphorylation of C-terminal serine residues by casein_kinase_II .
1639065	0	casein_kinase_II	64,80	DNA_ligase_I	24,36	casein kinase II	DNA ligase I	1457	100124507(Tax:9913)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mammalian DNA_ligase_I through phosphorylation by casein_kinase_II .
7852847	0	casein_kinase_II	14,30	IGF-1	82,87	casein kinase II	IGF-1	1457	3479	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|END_ENTITY	Activation of casein_kinase_II in ML-1 human myeloblastic_leukemia cells requires IGF-1 and transferrin .
8657113	0	casein_kinase_II	65,81	IkappaBalpha	19,31	casein kinase II	IkappaBalpha	1457	4792	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein_kinase_II affects intrinsic protein stability .
7645214	0	casein_kinase_II	24,40	P_protein	81,90	casein kinase II	P protein	1457	4948	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Involvement of cellular casein_kinase_II in the phosphorylation of measles_virus P_protein : identification of phosphorylation sites .
8977130	0	casein_kinase_II	33,49	actin	24,29	casein kinase II	actin	48448(Tax:7227)	40444(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	An inhibitory effect of actin on casein_kinase_II activity in vitro .
3321056	0	casein_kinase_II	14,30	insulin	46,53	casein kinase II	insulin	1457	3630	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of casein_kinase_II in response to insulin and to epidermal_growth_factor .
12417018	0	casein_kinase_I_epsilon	50,73	beta-catenin	34,46	casein kinase I epsilon	beta-catenin	102800317	1499	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and regulation of beta-catenin by casein_kinase_I_epsilon .
25332163	0	caspase	40,47	AKT1	18,22	caspase	AKT1	37729(Tax:7227)	41957(Tax:7227)	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Acinus integrates AKT1 and subapoptotic caspase activities to regulate basal autophagy .
11278283	0	caspase	21,28	MST	0,3	caspase	MST	177391(Tax:6239)	55154	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	MST , a physiological caspase substrate , highly sensitizes apoptosis both upstream and downstream of caspase activation .
11901173	0	caspase	28,35	cytochrome_c	12,24	caspase	cytochrome c	37729(Tax:7227)	34996(Tax:7227)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	The role of cytochrome_c in caspase activation in Drosophila_melanogaster cells .
24701032	0	caspase-1	116,125	AIM2	0,4	caspase-1	AIM2	834	9447	Gene	Gene	regulating|dobj|START_ENTITY mediates|advcl|regulating mediates|nsubj|END_ENTITY	AIM2 mediates inflammation-associated renal_damage in hepatitis_B_virus-associated glomerulonephritis by regulating caspase-1 , IL-1b , and IL-18 .
12193723	0	caspase-1	122,131	IL-18	135,140	caspase-1	IL-18	12362(Tax:10090)	16173(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	IL-18 levels and the outcome of innate immune response to lipopolysaccharide : importance of a positive feedback loop with caspase-1 in IL-18 expression .
23266381	0	caspase-1	90,99	IL-1b	70,75	caspase-1	IL-1b	834	3553	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Blockade of tumor necrosis factor-a converting enzyme -LRB- TACE -RRB- enhances IL-1b and IFN-y via caspase-1 activation : a probable cause for loss of efficacy of TACE inhibitors in humans ?
23884363	0	caspase-1	65,74	IL-1b	108,113	caspase-1	IL-1b	834	3553	Gene	Gene	START_ENTITY|acl:relcl|mediates mediates|dobj|secretion secretion|compound|END_ENTITY	Dengue_virus-infected human monocytes trigger late activation of caspase-1 , which mediates pro-inflammatory IL-1b secretion and pyroptosis .
24275551	0	caspase-1	108,117	IL-1b	62,67	caspase-1	IL-1b	834	3553	Gene	Gene	activation|nmod|START_ENTITY monocytes|nmod|activation enhances|nmod|monocytes enhances|dobj|secretion secretion|nmod|-18 -18|dep|END_ENTITY	Leptin enhances the secretion of interleukin _ -LRB- IL -RRB- -18 , but not IL-1b , from human monocytes via activation of caspase-1 .
26266796	0	caspase-1	111,120	IL-1b	0,5	caspase-1	IL-1b	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	dependent|advcl|START_ENTITY dependent|nsubj|processing processing|amod|END_ENTITY	IL-1b processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1 .
16394010	0	caspase-1	123,132	IL-1beta	97,105	caspase-1	IL-1beta	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	A potent adjuvant monophosphoryl_lipid_A triggers various immune responses , but not secretion of IL-1beta or activation of caspase-1 .
21270263	0	caspase-1	24,33	IL-1beta	53,61	caspase-1	IL-1beta	834	3553	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue .
24481253	0	caspase-1	8,17	IL-37	46,51	caspase-1	IL-37	12362(Tax:10090)	27178	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|translocation translocation|nmod|END_ENTITY	Role of caspase-1 in nuclear translocation of IL-37 , release of the cytokine , and IL-37 inhibition of innate immune responses .
16648852	0	caspase-1	52,61	Ipaf	29,33	caspase-1	Ipaf	834	58484	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin_1beta in salmonella-infected macrophages .
17696608	0	caspase-1	27,36	Ipaf	79,83	caspase-1	Ipaf	834	58484	Gene	Gene	activation|amod|START_ENTITY regulation|nmod|activation regulation|nmod|END_ENTITY	Differential regulation of caspase-1 activation , pyroptosis , and autophagy via Ipaf and ASC in Shigella-infected macrophages .
12650962	0	caspase-1	68,77	NF_kappa_B	57,67	caspase-1	NF kappa B	12362(Tax:10090)	18033(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Light-induced photoreceptor_degeneration may involve the NF_kappa_B / caspase-1 pathway in vivo .
25605870	0	caspase-1	47,56	NLRP3	19,24	caspase-1	NLRP3	834	114548	Gene	Gene	activation|amod|START_ENTITY activation|nummod|END_ENTITY	Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization .
25452302	0	caspase-1	39,48	Nedd8	0,5	caspase-1	Nedd8	834	4738	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Nedd8 regulates inflammasome-dependent caspase-1 activation .
16301671	0	caspase-1	16,25	P2X7_receptor	44,57	caspase-1	P2X7 receptor	12362(Tax:10090)	18439(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Potentiation of caspase-1 activation by the P2X7_receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis .
23356698	0	caspase-1	66,75	RIP-2	60,65	caspase-1	RIP-2	12362(Tax:10090)	192656(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Saengmaeksan inhibits inflammatory mediators by suppressing RIP-2 / caspase-1 activation .
19833722	0	caspase-1	13,22	Rab39a	0,6	caspase-1	Rab39a	834	54734	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion .
18604212	0	caspase-1	33,42	Superoxide_dismutase_1	0,22	caspase-1	Superoxide dismutase 1	12362(Tax:10090)	20655(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Superoxide_dismutase_1 regulates caspase-1 and endotoxic_shock .
12213439	0	caspase-1	34,43	bid	27,30	caspase-1	bid	12362(Tax:10090)	12122(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS .
26324711	0	caspase-1	71,80	interleukin-1_receptor-2	93,117	caspase-1	interleukin-1 receptor-2	834	7850	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
26324711	0	caspase-1	71,80	interleukin-1_receptor-2	93,117	caspase-1	interleukin-1 receptor-2	834	7850	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
26324711	0	caspase-1	71,80	interleukin-1_receptor-2	93,117	caspase-1	interleukin-1 receptor-2	834	7850	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
26324711	0	caspase-1	71,80	interleukin-1_receptor-2	93,117	caspase-1	interleukin-1 receptor-2	834	7850	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
17192486	0	caspase-1	14,23	interleukin-1beta	24,41	caspase-1	interleukin-1beta	12362(Tax:10090)	16176(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Inhibition of caspase-1 / interleukin-1beta signaling prevents degeneration_of_retinal_capillaries in diabetes and galactosemia .
8999805	0	caspase-1	22,31	p35	164,167	caspase-1	p35	834	3592	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Spodoptera frugiperda caspase-1 , a novel insect death protease that cleaves the nuclear immunophilin FKBP46 , is the target of the baculovirus antiapoptotic protein p35 .
26323380	0	caspase-10	105,115	CASP10	117,123	caspase-10	CASP10	843	843	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Autoimmune lymphoproliferative syndrome due to somatic FAS mutation -LRB- ALPS-sFAS -RRB- combined with a germline caspase-10 -LRB- CASP10 -RRB- variation .
26323380	0	caspase-10	105,115	CASP10	117,123	caspase-10	CASP10	843	843	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Autoimmune lymphoproliferative syndrome due to somatic FAS mutation -LRB- ALPS-sFAS -RRB- combined with a germline caspase-10 -LRB- CASP10 -RRB- variation .
18710920	0	caspase-12	23,33	Hip-2	7,12	caspase-12	Hip-2	12364(Tax:10090)	53323(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	E2-25K / Hip-2 regulates caspase-12 in ER stress-mediated Abeta_neurotoxicity .
25651379	0	caspase-14	115,125	GATA-3	108,114	caspase-14	GATA-3	23581	2625	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3 / caspase-14 pathway in A431 cells .
14599290	0	caspase-2	43,52	AlphaII-spectrin	0,16	caspase-2	AlphaII-spectrin	835	6709	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	AlphaII-spectrin is an in vitro target for caspase-2 , and its cleavage is regulated by calmodulin binding .
10086332	0	caspase-2	28,37	Bcl-2	0,5	caspase-2	Bcl-2	835	596	Gene	Gene	cascade|amod|START_ENTITY regulates|dobj|cascade regulates|nsubj|END_ENTITY	Bcl-2 regulates a caspase-3 / caspase-2 apoptotic cascade in cytosolic extracts .
20661774	0	caspase-2	50,59	Rock-2	90,96	caspase-2	Rock-2	835	9475	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Ouabain-induced apoptosis and Rho kinase : a novel caspase-2 cleavage site and fragment of Rock-2 .
21884983	0	caspase-2	114,123	Sirt1	77,82	caspase-2	Sirt1	835	23411	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	A biotin switch-based proteomics approach identifies 14-3-3 as a target of Sirt1 in the metabolic regulation of caspase-2 .
15983031	0	caspase-2	14,23	apoptosis-inducing_factor	63,88	caspase-2	apoptosis-inducing factor	835	9131	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing_factor and its role in renal tubular epithelial cell injury .
27049919	0	caspase-2	21,30	microRNA-149	0,12	caspase-2	microRNA-149	835	406941	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	microRNA-149 targets caspase-2 in glioma progression .
17385715	0	caspase-3	39,48	A_beta	102,108	caspase-3	A beta	836	351	Gene	Gene	forms|amod|START_ENTITY forms|nmod|END_ENTITY	Differential binding and activation of caspase-3 in cultured hippocampal neurons by assembly forms of A_beta 1-42 .
10632601	0	caspase-3	155,164	Akt	117,120	caspase-3	Akt	25402(Tax:10116)	24185(Tax:10116)	Gene	Gene	phosphorylation|advcl|START_ENTITY phosphorylation|nsubj|cells cells|nmod|death death|nmod|END_ENTITY	Insulin-like_growth_factor-I protects axotomized rat retinal_ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo .
15024023	0	caspase-3	84,93	Akt	0,3	caspase-3	Akt	836	207	Gene	Gene	inhibiting|xcomp|START_ENTITY apoptosis|advcl|inhibiting apoptosis|nsubj|blocks blocks|compound|END_ENTITY	Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion .
16885155	0	caspase-3	57,66	Akt	96,99	caspase-3	Akt	836	207	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	ERK promotes hydrogen_peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells .
19513559	0	caspase-3	132,141	Akt	168,171	caspase-3	Akt	836	207	Gene	Gene	activation|nmod|START_ENTITY associated|nmod|activation associated|nmod|downregulation downregulation|nmod|END_ENTITY	Induction of apoptosis in human lung_carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt .
22764594	0	caspase-3	47,56	Akt	76,79	caspase-3	Akt	12367(Tax:10090)	11651(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	-LSB- Effect of electroacupuncture on expression of caspase-3 and phosphorylated Akt proteins in the skeleton muscle in diabetic mice -RSB- .
24038446	0	caspase-3	44,53	Akt	27,30	caspase-3	Akt	836	207	Gene	Gene	activation|amod|START_ENTITY promotes|dobj|activation promotes|nsubj|Phosphorylation Phosphorylation|nmod|Smac Smac|nmod|END_ENTITY	Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells .
17462862	0	caspase-3	30,39	Akt1	55,59	caspase-3	Akt1	836	207	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin .
14960581	0	caspase-3	55,64	BAT3	77,81	caspase-3	BAT3	836	7917	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3 .
11144029	0	caspase-3	61,70	Bax	0,3	caspase-3	Bax	12367(Tax:10090)	12028(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression involved|nmod|regulation involved|nsubjpass|END_ENTITY	Bax and p53 are differentially involved in the regulation of caspase-3 expression and activation during neurodegeneration in Lurcher mice .
14612448	0	caspase-3	54,63	Bax	20,23	caspase-3	Bax	836	581	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis .
10086332	0	caspase-3	18,27	Bcl-2	0,5	caspase-3	Bcl-2	836	596	Gene	Gene	cascade|amod|START_ENTITY regulates|dobj|cascade regulates|nsubj|END_ENTITY	Bcl-2 regulates a caspase-3 / caspase-2 apoptotic cascade in cytosolic extracts .
11328751	0	caspase-3	67,76	Bcl-2	95,100	caspase-3	Bcl-2	836	596	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Blue light-induced apoptosis of A2E-containing RPE : involvement of caspase-3 and protection by Bcl-2 .
11393587	0	caspase-3	73,82	Bcl-2	103,108	caspase-3	Bcl-2	836	596	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Butein , a plant polyphenol , induces apoptosis concomitant with increased caspase-3 activity , decreased Bcl-2 expression and increased Bax expression in HL-60 cells .
11568056	0	caspase-3	30,39	Bcl-2	16,21	caspase-3	Bcl-2	25402(Tax:10116)	24224(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts .
11577002	0	caspase-3	93,102	Bcl-2	0,5	caspase-3	Bcl-2	836	596	Gene	Gene	activity|amod|START_ENTITY inhibition|nmod|activity attenuates|nmod|inhibition attenuates|nsubj|overexpression overexpression|amod|END_ENTITY	Bcl-2 overexpression attenuates resveratrol-induced apoptosis in U937 cells by inhibition of caspase-3 activity .
11992642	0	caspase-3	29,38	Bcl-2	51,56	caspase-3	Bcl-2	836	596	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|dep|END_ENTITY	Variation in the kinetics of caspase-3 activation , Bcl-2 phosphorylation and apoptotic morphology in unselected human ovarian_cancer cell lines as a response to docetaxel .
12148891	0	caspase-3	92,101	Bcl-2	120,125	caspase-3	Bcl-2	836	596	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|bax/ratio bax/ratio|compound|END_ENTITY	Hydroxychloroquine-induced apoptosis of chronic_lymphocytic_leukemia involves activation of caspase-3 and modulation of Bcl-2 / bax/ratio .
12150944	0	caspase-3	94,103	Bcl-2	128,133	caspase-3	Bcl-2	836	596	Gene	Gene	activation|amod|START_ENTITY activation|acl|regulated regulated|nmod|END_ENTITY	Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bcl-xL .
16002698	0	caspase-3	49,58	Bcl-2	11,16	caspase-3	Bcl-2	836	596	Gene	Gene	activation|amod|START_ENTITY levels|nmod|activation levels|compound|END_ENTITY	Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation : molecular genetic tests of computational model predictions .
16213739	0	caspase-3	49,58	Bcl-2	0,5	caspase-3	Bcl-2	836	596	Gene	Gene	activation|amod|START_ENTITY precedes|dobj|activation precedes|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic-ischemic_injury .
17096883	0	caspase-3	73,82	Bcl-2	101,106	caspase-3	Bcl-2	836	596	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Ouabain-induced apoptosis of Jurkat cells correlates with activation of caspase-3 and regulation of Bcl-2 gene family -RSB- .
17494993	0	caspase-3	28,37	Bcl-2	0,5	caspase-3	Bcl-2	12367(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|delays delays|amod|END_ENTITY	Bcl-2 overexpression delays caspase-3 activation and rescues cerebellar_degeneration in prion-deficient mice that overexpress amino-terminally truncated prion .
19408126	0	caspase-3	88,97	Bcl-2	73,78	caspase-3	Bcl-2	12367(Tax:10090)	12043(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediated|dobj|activation mediated|nsubj|apoptosis apoptosis|nmod|END_ENTITY	Glycogen_synthase_kinase-3beta regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells .
22467255	0	caspase-3	62,71	Bcl-2	90,95	caspase-3	Bcl-2	836	596	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	A pro-apoptotic 15-kDa protein from Bacopa monnieri activates caspase-3 and downregulates Bcl-2 gene expression in mouse mammary_carcinoma cells .
24496691	0	caspase-3	88,97	Bcl-2	116,121	caspase-3	Bcl-2	836	596	Gene	Gene	activation|nmod|START_ENTITY apoptosis|nmod|activation apoptosis|nmod|family family|compound|END_ENTITY	Dioscin-induced apoptosis of human LNCaP_prostate_carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family .
27064014	0	caspase-3	169,178	Bcl-2	201,206	caspase-3	Bcl-2	836	596	Gene	Gene	activation|amod|START_ENTITY induce|nmod|activation cytotoxic|xcomp|induce decreased|ccomp|cytotoxic decreased|nsubj|levels levels|compound|END_ENTITY	Isololiolide , a carotenoid metabolite isolated from the brown_alga_Cystoseira_tamariscifolia , is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation , decreased Bcl-2 levels , increased p53 expression and PARP cleavage .
9200447	0	caspase-3	67,76	Bcl-2	0,5	caspase-3	Bcl-2	836	596	Gene	Gene	family|amod|START_ENTITY inhibition|nmod|family functional|dobj|inhibition leads|xcomp|functional leads|nsubj|expression expression|amod|END_ENTITY	Bcl-2 expression in target cells leads to functional inhibition of caspase-3 protease family in human NK and lymphokine-activated killer cell granule-mediated apoptosis .
10446348	0	caspase-3	34,43	Bcl-xL	0,6	caspase-3	Bcl-xL	12367(Tax:10090)	12048(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY regulator|nmod|activation regulator|nsubj|END_ENTITY	Bcl-xL is a negative regulator of caspase-3 activation in immature neurons during development .
15610307	0	caspase-3	95,104	CD3zeta	67,74	caspase-3	CD3zeta	836	919	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Decreased expression of CD28 coincides with the down-modulation of CD3zeta and augmentation of caspase-3 activity in T cells from hepatocellular_carcinoma-bearing patients and hepatitis_C_virus-infected patients .
16116236	0	caspase-3	10,19	CD3zeta	66,73	caspase-3	CD3zeta	836	919	Gene	Gene	expression|amod|START_ENTITY contribute|nsubj|expression contribute|nmod|expression expression|amod|END_ENTITY	Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic_lupus_erythematosus T cells .
10812002	0	caspase-3	101,110	CPP32	111,116	caspase-3	CPP32	836	836	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	TNF-alpha induces apoptosis mediated by AEBSF-sensitive serine_protease -LRB- s -RRB- that may involve upstream caspase-3 / CPP32 protease activation in a human gastric_cancer cell line .
9305886	0	caspase-3	86,95	CPP32	96,101	caspase-3	CPP32	836	836	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	CD95/Fas-induced ceramide formation proceeds with slow kinetics and is not blocked by caspase-3 / CPP32 inhibition .
9720729	0	caspase-3	34,43	CPP32	45,50	caspase-3	CPP32	836	836	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vinorelbine induces apoptosis and caspase-3 -LRB- CPP32 -RRB- expression in leukemia and lymphoma cells : a comparison with vincristine .
14612448	0	caspase-3	54,63	Calpain-1	0,9	caspase-3	Calpain-1	836	823	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis .
23540413	0	caspase-3	32,41	Caspase-2	0,9	caspase-3	Caspase-2	836	835	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells .
10388534	0	caspase-3	19,28	Caspase-8	0,9	caspase-3	Caspase-8	836	841	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Caspase-8 mediates caspase-3 activation and cytochrome_c release during singlet oxygen-induced apoptosis of HL-60 cells .
11550085	0	caspase-3	24,33	Caspase-9	0,9	caspase-3	Caspase-9	12367(Tax:10090)	12371(Tax:10090)	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo .
17250449	0	caspase-3	126,135	Cox-2	103,108	caspase-3	Cox-2	12367(Tax:10090)	17709(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Black tea polyphenols restrict benzopyrene-induced mouse lung_cancer progression through inhibition of Cox-2 and induction of caspase-3 expression .
16885155	0	caspase-3	57,66	ERK	0,3	caspase-3	ERK	836	5594	Gene	Gene	activation|amod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	ERK promotes hydrogen_peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells .
16449966	0	caspase-3	14,23	Id3	0,3	caspase-3	Id3	836	3399	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Id3 induces a caspase-3 - and -9 - dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes .
19229714	0	caspase-3	53,62	Inducible_nitric_oxide_synthase	0,31	caspase-3	Inducible nitric oxide synthase	12367(Tax:10090)	18126(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Inducible_nitric_oxide_synthase mediates hippocampal caspase-3 activation in pneumococcal_meningitis .
17114647	0	caspase-3	23,32	Interleukin-4	0,13	caspase-3	Interleukin-4	836	3565	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits caspase-3 by regulating several proteins in the Fas pathway during initial stages of human T helper 2 cell differentiation .
21827835	0	caspase-3	44,53	MicroRNA_let-7e	0,15	caspase-3	MicroRNA let-7e	25402(Tax:10116)	100313991(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA_let-7e regulates the expression of caspase-3 during apoptosis of PC12 cells following anoxia/reoxygenation injury .
10381633	0	caspase-3	32,41	P19	59,62	caspase-3	P19	12367(Tax:10090)	83430(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	bFGF inhibits the activation of caspase-3 and apoptosis of P19 embryonal_carcinoma cells during neuronal differentiation .
25821312	0	caspase-3	27,36	P53	38,41	caspase-3	P53	836	7157	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of bleomycin A5 on caspase-3 , P53 , bcl-2 expression and telomerase activity in vascular endothelial cells .
16405863	0	caspase-3	139,148	PARP	190,194	caspase-3	PARP	836	142	Gene	Gene	polymerase|amod|START_ENTITY polymerase|appos|END_ENTITY	Detection of cleaved alpha-fodrin autoantigen in Sj gren 's _ syndrome : apoptosis and co-localisation of cleaved alpha-fodrin with activated caspase-3 and cleaved poly -LRB- ADP-ribose -RRB- _ polymerase -LRB- PARP -RRB- in labial salivary glands .
17404069	0	caspase-3	54,63	PARP	80,84	caspase-3	PARP	836	142	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Resveratrol inhibits IL-1_beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro .
19029405	0	caspase-3	58,67	PARP	98,102	caspase-3	PARP	836	142	Gene	Gene	immunohistochemistry|advcl|START_ENTITY apoptosis|acl|immunohistochemistry Assessment|nmod|apoptosis END_ENTITY|nsubj|Assessment	Assessment of apoptosis by immunohistochemistry to active caspase-3 , active caspase-7 , or cleaved PARP in monolayer cells and spheroid and subcutaneous xenografts of human carcinoma .
23161104	0	caspase-3	35,44	PARP	45,49	caspase-3	PARP	836	142	Gene	Gene	/|amod|START_ENTITY induced|dobj|/ glucose|acl|induced levels|nmod|glucose END_ENTITY|nsubj|levels	High levels of glucose induced the caspase-3 / PARP signaling pathway , leading to apoptosis in human periodontal ligament fibroblasts .
24728469	0	caspase-3	55,64	PARP	65,69	caspase-3	PARP	836	142	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Zebularine induces prolonged apoptosis effects via the caspase-3 / PARP pathway in head_and_neck_cancer cells .
26367448	0	caspase-3	15,24	PTEN	25,29	caspase-3	PTEN	836	5728	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|parataxis|signaling signaling|nsubj|END_ENTITY	Involvement of caspase-3 / PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells .
26367448	0	caspase-3	15,24	PTEN	25,29	caspase-3	PTEN	836	5728	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|parataxis|signaling signaling|nsubj|END_ENTITY	Involvement of caspase-3 / PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells .
15950730	0	caspase-3	27,36	TCR	63,66	caspase-3	TCR	836	6962	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Selective up-regulation of caspase-3 gene expression following TCR engagement .
14505549	0	caspase-3	30,39	Tumor_necrosis_factor-alpha	1,28	caspase-3	Tumor necrosis factor-alpha	12367(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	-LSB- Tumor_necrosis_factor-alpha , caspase-3 expression and hepatocyte apoptosis in fulminanting hepatic_failure -RSB- .
11257232	0	caspase-3	39,48	XIAP	52,56	caspase-3	XIAP	836	331	Gene	Gene	inhibition|nmod|START_ENTITY basis|nmod|inhibition basis|nmod|END_ENTITY	Structural basis for the inhibition of caspase-3 by XIAP .
12181739	0	caspase-3	19,28	XIAP	0,4	caspase-3	XIAP	836	331	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95 - and Bax-induced apoptosis .
12826269	0	caspase-3	81,90	XIAP	114,118	caspase-3	XIAP	836	331	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Immunosuppressant PG490 -LRB- triptolide -RRB- induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells .
17291493	0	caspase-3	188,197	XIAP	8,12	caspase-3	XIAP	836	331	Gene	Gene	activation|amod|START_ENTITY enhancing|dobj|activation mimic|advcl|enhancing molecule|acl:relcl|mimic Role|dep|molecule Role|nmod|END_ENTITY	Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small_cell_lung_cancer cells : a small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation .
17724022	0	caspase-3	48,57	XIAP	72,76	caspase-3	XIAP	836	331	Gene	Gene	inhibition|amod|START_ENTITY relieves|dobj|inhibition relieves|nmod|END_ENTITY	A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP .
22732633	0	caspase-3	84,93	XIAP	129,133	caspase-3	XIAP	12367(Tax:10090)	11798(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY effects|nmod|activation effects|nmod|END_ENTITY	Anti-cancer effects of thymoquinone in mouse neuroblastoma -LRB- Neuro-2a -RRB- cells through caspase-3 activation with down-regulation of XIAP .
23156805	0	caspase-3	48,57	XIAP	42,46	caspase-3	XIAP	836	331	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	-LSB- The expression and significance of smac , XIAP , caspase-3 in nonnasal_inverted_papilloma -RSB- .
15631088	0	caspase-3	53,62	bcl-2	46,51	caspase-3	bcl-2	25402(Tax:10116)	24224(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Effects of Carthamus tinctorius injection on bcl-2 , caspase-3 expression related to neurons apoptosis after local cerebral_ischemia -RSB- .
16548358	0	caspase-3	78,87	bcl-2	119,124	caspase-3	bcl-2	25402(Tax:10116)	24224(Tax:10116)	Gene	Gene	molecule|amod|START_ENTITY expression|nmod|molecule TX0201|nmod|expression Effect|nmod|TX0201 associated|nsubj|Effect associated|xcomp|END_ENTITY	-LSB- Effect of TX0201 on expression of the apoptosis signal transduction molecule caspase-3 and apoptosis associated genes bcl-2 and bax mRNA in brain tissue of rat analogue model of Alzheimer 's _ disease -RSB- .
17951202	0	caspase-3	32,41	bcl-2	6,11	caspase-3	bcl-2	836	596	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Human bcl-2 expression , cleaved caspase-3 , and KSHV LANA-1 in Kaposi_sarcoma lesions .
18514416	0	caspase-3	120,129	bcl-2	72,77	caspase-3	bcl-2	12367(Tax:10090)	12043(Tax:10090)	Gene	Gene	application|nmod|START_ENTITY application|nmod|transcription transcription|amod|END_ENTITY	Chronic application of nonylphenol-induced apoptosis via suppression of bcl-2 transcription and up-regulation of active caspase-3 in mouse brain .
25821312	0	caspase-3	27,36	bcl-2	43,48	caspase-3	bcl-2	836	596	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Effects of bleomycin A5 on caspase-3 , P53 , bcl-2 expression and telomerase activity in vascular endothelial cells .
9808574	0	caspase-3	87,96	bcl-2	117,122	caspase-3	bcl-2	836	596	Gene	Gene	START_ENTITY|nmod|evidence evidence|nmod|modulation modulation|amod|END_ENTITY	Flavopiridol induces apoptosis in chronic_lymphocytic_leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53 .
16320828	0	caspase-3	139,148	beta1-integrin	95,109	caspase-3	beta1-integrin	836	3688	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3 : an immunomorphological study .
25501826	0	caspase-3	14,23	cIAP2	38,43	caspase-3	cIAP2	836	330	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia .
20675131	0	caspase-3	93,102	caspase-8	83,92	caspase-3	caspase-8	836	841	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8 / caspase-3 activation .
21984154	0	caspase-3	95,104	caspase-8	106,115	caspase-3	caspase-8	12367(Tax:10090)	12370(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of Mycobacterium_tuberculosis on apoptosis of mouse dendritic cells and activation of caspase-3 , caspase-8 -RSB- .
11973426	0	caspase-3	84,93	caspase-9	36,45	caspase-3	caspase-9	25402(Tax:10116)	58918(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY mediating|dobj|activation role|acl|mediating implications|nmod|role Cloning|dep|implications Cloning|nmod|END_ENTITY	Cloning and characterization of rat caspase-9 : implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral_ischemia .
12437970	0	caspase-3	58,67	caspase-9	48,57	caspase-3	caspase-9	836	842	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Ceramide induces neuronal apoptosis through the caspase-9 / caspase-3 pathway .
12506111	0	caspase-3	49,58	caspase-9	25,34	caspase-3	caspase-9	836	842	Gene	Gene	apoptosome|nmod|START_ENTITY apoptosome|amod|END_ENTITY	Regulation of the Apaf-1 / caspase-9 apoptosome by caspase-3 and XIAP .
22944165	0	caspase-3	137,146	caspase-9	127,136	caspase-3	caspase-9	836	842	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|nsubj|O O|dep|induced induced|nmod|down-regulation down-regulation|nmod|END_ENTITY	-LSB- Atorvastatin inhibits the H ___ O - induced apoptosis of human vascular endothelial cells through a down-regulation of cleaved caspase-9 / caspase-3 -RSB- .
24563336	0	caspase-3	81,90	caspase-9	91,100	caspase-3	caspase-9	836	842	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Oxymatrine triggers apoptosis by regulating Bcl-2 family proteins and activating caspase-3 / caspase-9 pathway in human leukemia HL-60 cells .
25891909	0	caspase-3	152,161	caspase-9	142,151	caspase-3	caspase-9	836	842	Gene	Gene	cleavage|amod|START_ENTITY cleavage|amod|END_ENTITY	Photoactivation of hypericin decreases the viability of RINm5F_insulinoma cells through reduction of JNK/ERK phosphorylation and elevation of caspase-9 / caspase-3 cleavage and Bax-to-Bcl-2 ratio .
26182357	0	caspase-3	152,161	caspase-9	142,151	caspase-3	caspase-9	836	842	Gene	Gene	cleavage|amod|START_ENTITY cleavage|amod|END_ENTITY	Photoactivation of hypericin decreases the viability of RINm5F_insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9 / caspase-3 cleavage and Bax-to-Bcl-2 ratio .
17089125	0	caspase-3	64,73	cyclooxygenase-2	18,34	caspase-3	cyclooxygenase-2	836	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome_proliferator-activated_receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro .
10393962	0	caspase-3	88,97	cytochrome_c	39,51	caspase-3	cytochrome c	836	54205	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Apoptosis in heart_failure : release of cytochrome_c from mitochondria and activation of caspase-3 in human cardiomyopathy .
10822279	0	caspase-3	140,149	cytochrome_c	233,245	caspase-3	cytochrome c	836	54205	Gene	Gene	START_ENTITY|dep|loop loop|nmod|amplification amplification|nmod|release release|amod|END_ENTITY	Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3 : a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome_c release .
10915781	0	caspase-3	136,145	cytochrome_c	105,117	caspase-3	cytochrome c	836	54205	Gene	Gene	efflux|nmod|START_ENTITY efflux|nmod|END_ENTITY	Autocrine gastrins in colon_cancer cells Up-regulate cytochrome_c oxidase Vb and down-regulate efflux of cytochrome_c and activation of caspase-3 .
10915781	0	caspase-3	136,145	cytochrome_c	53,65	caspase-3	cytochrome c	836	54205	Gene	Gene	efflux|nmod|START_ENTITY oxidase|dobj|efflux oxidase|nsubj|gastrins gastrins|nmod|cells cells|amod|END_ENTITY	Autocrine gastrins in colon_cancer cells Up-regulate cytochrome_c oxidase Vb and down-regulate efflux of cytochrome_c and activation of caspase-3 .
11274139	0	caspase-3	121,130	cytochrome_c	69,81	caspase-3	cytochrome c	836	54205	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	The small heat_shock protein alpha B-crystallin negatively regulates cytochrome_c - and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation .
11503418	0	caspase-3	64,73	cytochrome_c	36,48	caspase-3	cytochrome c	836	54205	Gene	Gene	deoxyguanosine|amod|START_ENTITY activation|nmod|deoxyguanosine END_ENTITY|appos|activation	Biomarkers of apoptosis : release of cytochrome_c , activation of caspase-3 , induction of 8-hydroxy-2 ' - deoxyguanosine , increased 3-nitrotyrosine , and alteration of p53 gene .
11997663	0	caspase-3	95,104	cytochrome_c	13,25	caspase-3	cytochrome c	836	54205	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|Induction Induction|nmod|release release|amod|END_ENTITY	Induction of cytochrome_c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3 .
26334686	0	caspase-3	63,72	cytochrome_c	39,51	caspase-3	cytochrome c	836	54205	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Purification and characterization of a cytochrome_c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus_arrhizus .
16286477	0	caspase-3	74,83	desmoglein_1	50,62	caspase-3	desmoglein 1	836	1828	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	The differentiation-dependent desmosomal cadherin desmoglein_1 is a novel caspase-3 target that regulates apoptosis in keratinocytes .
24565837	0	caspase-3	76,85	focal_adhesion_kinase	127,148	caspase-3	focal adhesion kinase	836	5747	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Saikosaponin_C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal_adhesion_kinase in human umbilical vein endothelial cells .
12228224	0	caspase-3	87,96	glycogen_synthase_kinase-3beta	16,46	caspase-3	glycogen synthase kinase-3beta	836	2932	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Central role of glycogen_synthase_kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation .
20150439	0	caspase-3	118,127	insulin-like_growth_factor_binding_protein_2	8,52	caspase-3	insulin-like growth factor binding protein 2	836	3485	Gene	Gene	effect|nmod|START_ENTITY Role|dep|effect Role|nmod|END_ENTITY	Role of insulin-like_growth_factor_binding_protein_2 in lung_adenocarcinoma : IGF-independent antiapoptotic effect via caspase-3 .
23345589	0	caspase-3	37,46	myosin_phosphatase_targeting_subunit_1	79,117	caspase-3	myosin phosphatase targeting subunit 1	836	4659	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin_phosphatase_targeting_subunit_1 during apoptosis .
10187863	1	caspase-3	118,127	neutral_sphingomyelinase	89,113	caspase-3	neutral sphingomyelinase	836	6610	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of magnesium-dependent neutral_sphingomyelinase via caspase-3 .
17160024	0	caspase-3	126,135	osteopontin	78,89	caspase-3	osteopontin	12367(Tax:10090)	20750(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Chemotherapy resistance of mouse WAP-SVT/t breast_cancer cells is mediated by osteopontin , inhibiting apoptosis downstream of caspase-3 .
9148968	0	caspase-3	81,90	p12	69,72	caspase-3	p12	836	56655	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	A sequential two-step mechanism for the production of the mature p17 : p12 form of caspase-3 in vitro .
12763761	0	caspase-3	24,33	p17	4,7	caspase-3	p17	12367(Tax:10090)	108900(Tax:10090)	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic_plaque .
11129259	0	caspase-3	27,36	p53	80,83	caspase-3	p53	836	7157	Gene	Gene	activation|amod|START_ENTITY apoptosis|nmod|activation apoptosis|acl|carrying carrying|dobj|END_ENTITY	Heat-induced apoptosis via caspase-3 activation in tumour cells carrying mutant p53 .
11346471	0	caspase-3	16,25	p53	37,40	caspase-3	p53	25402(Tax:10116)	301300(Tax:10116)	Gene	Gene	Contribution|nmod|START_ENTITY differs|nsubj|Contribution differs|nmod|status status|compound|END_ENTITY	Contribution of caspase-3 differs by p53 status in apoptosis induced by X-irradiation .
12791380	0	caspase-3	160,169	p53	129,132	caspase-3	p53	12367(Tax:10090)	22060(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY convergence|nmod|activation expression|dep|convergence expression|compound|END_ENTITY	Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression : convergence at caspase-3 activation .
12945745	0	caspase-3	29,38	p53	10,13	caspase-3	p53	836	7157	Gene	Gene	activity|amod|START_ENTITY levels|nmod|activity levels|compound|END_ENTITY	Increased p53 levels without caspase-3 activity and change of cell viability in 6-hydroxydopamine-treated CV1-P cells .
15004518	0	caspase-3	70,79	p53	0,3	caspase-3	p53	836	7157	Gene	Gene	activation|amod|START_ENTITY correlate|nmod|activation correlate|nsubj|dephosphorylation dephosphorylation|compound|END_ENTITY	p53 dephosphorylation and p21 -LRB- Cip1/Waf1 -RRB- translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells .
21307660	0	caspase-3	62,71	p53	21,24	caspase-3	p53	836	7157	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|proteins proteins|compound|END_ENTITY	Wild-type and mutant p53 proteins interact with mitochondrial caspase-3 .
25108346	0	caspase-3	99,108	p53	65,68	caspase-3	p53	12367(Tax:10090)	22060(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY exhibits|nmod|activity exhibits|dobj|apoptogenesis apoptogenesis|nummod|END_ENTITY	DAO-9 _ -LRB- 2,5-di -LRB- 4-aryloylaryloxymethyl -RRB- -1,3,4 - oxadiazole -RRB- exhibits p53 induced apoptogenesis through caspase-3 mediated endonuclease activity in murine carcinoma .
27064014	0	caspase-3	169,178	p53	225,228	caspase-3	p53	836	7157	Gene	Gene	activation|amod|START_ENTITY induce|nmod|activation cytotoxic|xcomp|induce decreased|ccomp|cytotoxic decreased|nsubj|levels levels|appos|expression expression|compound|END_ENTITY	Isololiolide , a carotenoid metabolite isolated from the brown_alga_Cystoseira_tamariscifolia , is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation , decreased Bcl-2 levels , increased p53 expression and PARP cleavage .
21914039	0	caspase-3	59,68	prohibitin	19,29	caspase-3	prohibitin	25402(Tax:10116)	25344(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|nmod|END_ENTITY	Less expression of prohibitin is associated with increased caspase-3 expression and cell apoptosis in renal_interstitial_fibrosis rats .
10608812	0	caspase-3	43,52	rabaptin-5	6,16	caspase-3	rabaptin-5	836	9135	Gene	Gene	cleaved|advcl|START_ENTITY cleaved|nsubjpass|END_ENTITY	Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis .
18832097	0	caspase-3	48,57	vitamin_D_receptor	26,44	caspase-3	vitamin D receptor	836	7421	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of the human vitamin_D_receptor by caspase-3 .
15273717	0	caspase-6	14,23	ARK5	59,63	caspase-6	ARK5	839	9891	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of caspase-6 and FLIP by the AMPK family member ARK5 .
16123779	0	caspase-6	24,33	Caspase-1	0,9	caspase-6	Caspase-1	839	834	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Caspase-1 activation of caspase-6 in human apoptotic neurons .
16777606	0	caspase-6	16,25	huntingtin	99,109	caspase-6	huntingtin	12368(Tax:10090)	15194(Tax:10090)	Gene	Gene	site|amod|START_ENTITY Cleavage|nmod|site required|nsubjpass|Cleavage required|nmod|neuronal_dysfunction neuronal_dysfunction|amod|due due|nmod|END_ENTITY	Cleavage at the caspase-6 site is required for neuronal_dysfunction and degeneration due to mutant huntingtin .
18445618	0	caspase-6	10,19	huntingtin	55,65	caspase-6	huntingtin	12368(Tax:10090)	15194(Tax:10090)	Gene	Gene	fragments|amod|START_ENTITY fragments|nmod|END_ENTITY	Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus .
21068307	0	caspase-6	31,40	huntingtin	56,66	caspase-6	huntingtin	839	3064	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Cleavage at the 586 amino_acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo .
21068307	0	caspase-6	78,87	huntingtin	56,66	caspase-6	huntingtin	839	3064	Gene	Gene	activation|amod|START_ENTITY influences|dobj|activation influences|nsubj|Cleavage Cleavage|nmod|site site|nmod|END_ENTITY	Cleavage at the 586 amino_acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo .
24070868	0	caspase-6	14,23	huntingtin	85,95	caspase-6	huntingtin	12368(Tax:10090)	15194(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|tissue tissue|acl|expressing expressing|dobj|END_ENTITY	p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin .
24070868	0	caspase-6	14,23	p53	0,3	caspase-6	p53	12368(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin .
22659571	0	caspase-7	65,74	TDP-43	96,102	caspase-7	TDP-43	840	23435	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function .
10648830	0	caspase-7	80,89	endothelial_monocyte-activating_polypeptide_II	4,50	caspase-7	endothelial monocyte-activating polypeptide II	840	9255	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The endothelial_monocyte-activating_polypeptide_II -LRB- EMAP_II -RRB- is a substrate for caspase-7 .
22644571	0	caspase-8	28,37	Atg3	12,16	caspase-8	Atg3	841	64422	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death .
11756235	0	caspase-8	69,78	BID	80,83	caspase-8	BID	841	637	Gene	Gene	release|amod|START_ENTITY release|dep|END_ENTITY	Curcumin -LRB- diferuloylmethane -RRB- induces apoptosis through activation of caspase-8 , BID cleavage and cytochrome_c release : its suppression by ectopic expression of Bcl-2 and Bcl-xl .
21072056	0	caspase-8	18,27	BID	0,3	caspase-8	BID	841	637	Gene	Gene	cleaved|advcl|START_ENTITY cleaved|nsubjpass|END_ENTITY	BID is cleaved by caspase-8 within a native complex on the mitochondrial membrane .
20203689	0	caspase-8	70,79	Bax	83,86	caspase-8	Bax	841	581	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Glucose_deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax - , Bak-deficient cells .
12196516	0	caspase-8	57,66	Bid	145,148	caspase-8	Bid	12370(Tax:10090)	12122(Tax:10090)	Gene	Gene	signal|xcomp|START_ENTITY signal|nmod|END_ENTITY	TRAIL receptor and CD95 signal to mitochondria via FADD , caspase-8 / 10 , Bid , and Bax but differentially regulate events downstream from truncated Bid .
15579484	0	caspase-8	18,27	Bid	28,31	caspase-8	Bid	841	637	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|pathways pathways|nsubj|END_ENTITY	Activation of the caspase-8 / Bid and Bax pathways in aspirin-induced apoptosis in gastric_cancer .
17431792	0	caspase-8	27,36	Bid	0,3	caspase-8	Bid	841	637	Gene	Gene	activation|amod|START_ENTITY upstream|nmod|activation cleaved|advmod|upstream cleaved|nsubjpass|END_ENTITY	Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells .
20356928	0	caspase-8	59,68	Bid	41,44	caspase-8	Bid	841	637	Gene	Gene	activation|amod|START_ENTITY cleavage|nmod|activation cleavage|nsubj|Activity Activity|nmod|END_ENTITY	Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation .
11739563	0	caspase-8	43,52	Caspase-9	0,9	caspase-8	Caspase-9	12370(Tax:10090)	12371(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY results|nmod|activation results|amod|END_ENTITY	Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine-induced Parkinson 's _ disease .
18087262	0	caspase-8	18,27	DR5	0,3	caspase-8	DR5	841	8795	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo .
11859411	0	caspase-8	84,93	FADD	62,66	caspase-8	FADD	841	8772	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Induction of apoptosis by chemotherapeutic drugs : the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian_carcinoma cells .
12196516	0	caspase-8	57,66	FADD	51,55	caspase-8	FADD	12370(Tax:10090)	14082(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mitochondria mitochondria|nmod|END_ENTITY	TRAIL receptor and CD95 signal to mitochondria via FADD , caspase-8 / 10 , Bid , and Bax but differentially regulate events downstream from truncated Bid .
18840411	0	caspase-8	57,66	FADD	50,54	caspase-8	FADD	841	8772	Gene	Gene	DR5|dep|START_ENTITY DR5|dep|END_ENTITY	c-FLIP knockdown induces ligand-independent DR5 - , FADD - , caspase-8 - , and caspase-9-dependent apoptosis in breast_cancer cells .
12535213	0	caspase-8	86,95	Fas_ligand	0,10	caspase-8	Fas ligand	841	356	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Fas_ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8 .
22267217	0	caspase-8	106,115	IL-1b	81,86	caspase-8	IL-1b	841	3553	Gene	Gene	inflammasome|amod|START_ENTITY END_ENTITY|nmod|inflammasome	Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1b via a noncanonical caspase-8 inflammasome .
22538414	0	caspase-8	64,73	IL-6	44,48	caspase-8	IL-6	841	3569	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Amphotericin_B up-regulates lipid_A-induced IL-6 production via caspase-8 .
11059759	0	caspase-8	36,45	Interferon-gamma	0,16	caspase-8	Interferon-gamma	841	3458	Gene	Gene	expression|amod|START_ENTITY elevates|dobj|expression elevates|nsubj|treatment treatment|amod|END_ENTITY	Interferon-gamma treatment elevates caspase-8 expression and sensitizes human breast_tumor cells to a death receptor-induced mitochondria-operated apoptotic program .
15065018	0	caspase-8	25,34	Interferon-gamma	0,16	caspase-8	Interferon-gamma	841	3458	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter .
15065018	0	caspase-8	86,95	Interferon-gamma	0,16	caspase-8	Interferon-gamma	841	3458	Gene	Gene	promoter|amod|START_ENTITY methylation|nmod|promoter affecting|dobj|methylation induces|advcl|affecting induces|nsubj|END_ENTITY	Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter .
17525260	0	caspase-8	149,158	Interferon-gamma	0,16	caspase-8	Interferon-gamma	841	3458	Gene	Gene	up-regulation|nmod|START_ENTITY resistant|nmod|up-regulation resistant|nsubj|sensitizes sensitizes|amod|END_ENTITY	Interferon-gamma sensitizes resistant Ewing 's _ sarcoma cells to tumor_necrosis_factor_apoptosis-inducing_ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity .
17627812	0	caspase-8	43,52	Interferon-gamma	0,16	caspase-8	Interferon-gamma	841	3458	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio - and chemotherapy .
10799332	0	caspase-8	32,41	NF-kappaB	80,89	caspase-8	NF-kappaB	841	4790	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Adenovirus-mediated transfer of caspase-8 in combination with superrepressor of NF-kappaB drastically induced apoptosis in gliomas .
9765224	0	caspase-8	47,56	Pro-caspase-3	0,13	caspase-8	Pro-caspase-3	841	836	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Pro-caspase-3 is a major physiologic target of caspase-8 .
19641134	0	caspase-8	68,77	RIP1	35,39	caspase-8	RIP1	841	8737	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Membrane-bound Fas_ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex .
22585859	0	caspase-8	66,75	RIP1	52,56	caspase-8	RIP1	841	8737	Gene	Gene	apoptosis|amod|START_ENTITY inhibits|dobj|apoptosis inhibits|nsubj|polyubiquitination polyubiquitination|nmod|END_ENTITY	A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma .
22095280	0	caspase-8	139,148	TNF	165,168	caspase-8	TNF	12370(Tax:10090)	21926(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	In mouse embryonic fibroblasts , neither caspase-8 nor cellular FLICE-inhibitory_protein -LRB- FLIP -RRB- is necessary for TNF to activate NF-kB , but caspase-8 is required for TNF to cause cell death , and induction of FLIP by NF-kB is required to prevent it .
19119023	0	caspase-8	68,77	TNFalpha	50,58	caspase-8	TNFalpha	12370(Tax:10090)	21926(Tax:10090)	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim .
10548502	0	caspase-8	32,41	TRAIL	0,5	caspase-8	TRAIL	841	8743	Gene	Gene	causes|nmod|START_ENTITY causes|nsubj|END_ENTITY	TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells .
11032723	0	caspase-8	18,27	TRAIL	52,57	caspase-8	TRAIL	841	8743	Gene	Gene	sensitizes|amod|START_ENTITY Reconstitution|nmod|sensitizes JB6|nsubj|Reconstitution JB6|nmod|END_ENTITY	Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL .
11221844	0	caspase-8	95,104	TRAIL	87,92	caspase-8	TRAIL	841	8743	Gene	Gene	required|nsubjpass|START_ENTITY ligand|acl:relcl|required ligand|appos|END_ENTITY	Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- : caspase-8 is required for TRAIL-induced apoptosis .
11245427	0	caspase-8	145,154	TRAIL	71,76	caspase-8	TRAIL	841	8743	Gene	Gene	expression|amod|START_ENTITY apoptosis|nmod|expression tumor_necrosis_factor-related_apoptosis-inducing_ligand|dep|apoptosis tumor_necrosis_factor-related_apoptosis-inducing_ligand|appos|END_ENTITY	Resistance to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression .
11384965	0	caspase-8	47,56	TRAIL	163,168	caspase-8	TRAIL	841	8743	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|c-Fos c-Fos|nmod|Fas Fas|appos|END_ENTITY	Fas-associated_death_domain_protein -LRB- FADD -RRB- and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- via a FLICE inhibitory protein -LRB- FLIP -RRB- - regulated pathway .
12196516	0	caspase-8	57,66	TRAIL	0,5	caspase-8	TRAIL	12370(Tax:10090)	22035(Tax:10090)	Gene	Gene	signal|xcomp|START_ENTITY signal|nsubj|receptor receptor|compound|END_ENTITY	TRAIL receptor and CD95 signal to mitochondria via FADD , caspase-8 / 10 , Bid , and Bax but differentially regulate events downstream from truncated Bid .
16036110	0	caspase-8	27,36	TRAIL	61,66	caspase-8	TRAIL	841	8743	Gene	Gene	protein|amod|START_ENTITY degradation|nmod|protein correlates|nsubj|degradation correlates|nmod|resistance resistance|amod|END_ENTITY	Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon_cancer cell line .
16434995	0	caspase-8	43,52	TRAIL	0,5	caspase-8	TRAIL	841	8743	Gene	Gene	dependent|amod|START_ENTITY dependent|nsubj|sensitisation sensitisation|amod|END_ENTITY	TRAIL sensitisation by arsenic_trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt .
16750275	0	caspase-8	36,45	TRAIL	85,90	caspase-8	TRAIL	841	8743	Gene	Gene	transfection|nmod|START_ENTITY sensitizes|nsubj|transfection sensitizes|nmod|death death|amod|END_ENTITY	Adenovirus-mediated transfection of caspase-8 sensitizes hepatocellular_carcinoma to TRAIL - and chemotherapeutic agent-induced cell death .
19597472	0	caspase-8	147,156	TRAIL	101,106	caspase-8	TRAIL	841	8743	Gene	Gene	silencing|advcl|START_ENTITY overcome|advcl|silencing overcome|dobj|resistance resistance|amod|END_ENTITY	Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8 .
20442297	0	caspase-8	101,110	TRAIL	53,58	caspase-8	TRAIL	841	8743	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Bortezomib sensitizes human renal_cell_carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex .
21454681	0	caspase-8	141,150	TRAIL	67,72	caspase-8	TRAIL	841	8743	Gene	Gene	processing|nmod|START_ENTITY irrespective|nmod|processing irrespective|amod|END_ENTITY	Cellular FLICE-inhibitory protein -LRB- cFLIP -RRB- isoforms block CD95 - and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex .
21771726	0	caspase-8	78,87	TRAIL	128,133	caspase-8	TRAIL	841	8743	Gene	Gene	expression|amod|START_ENTITY restores|dobj|expression restores|nmod|END_ENTITY	Combined inhibition of DNA methyltransferase and histone_deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL .
22408249	0	caspase-8	33,42	TRAIL	152,157	caspase-8	TRAIL	841	8743	Gene	Gene	activation|amod|START_ENTITY impair|dobj|activation impair|nmod|stimulation stimulation|nmod|signaling signaling|appos|END_ENTITY	Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor_necrosis_factor-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- signaling .
23096115	0	caspase-8	43,52	TRAIL	84,89	caspase-8	TRAIL	841	8743	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-kB by TRAIL .
23678861	0	caspase-8	73,82	TRAIL	116,121	caspase-8	TRAIL	841	8743	Gene	Gene	trafficking|amod|START_ENTITY trafficking|nmod|receptosomes receptosomes|amod|END_ENTITY	Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes .
22922291	0	caspase-8	63,72	Tumor_necrosis_factor_a	0,23	caspase-8	Tumor necrosis factor a	841	7124	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_a stimulates Her-2 cleavage by activated caspase-8 .
19940360	0	caspase-8	133,142	apoptosis_signal-regulating_kinase_1	61,97	caspase-8	apoptosis signal-regulating kinase 1	841	4217	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Fas-induced apoptosis of renal_cell_carcinoma is mediated by apoptosis_signal-regulating_kinase_1 via mitochondrial damage-dependent caspase-8 activation .
10548502	0	caspase-8	32,41	bid	25,28	caspase-8	bid	841	637	Gene	Gene	causes|nmod|START_ENTITY causes|dobj|cleavage cleavage|nmod|END_ENTITY	TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells .
12754217	0	caspase-8	93,102	bid	103,106	caspase-8	bid	841	637	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8 / bid pathway .
12110583	0	caspase-8	43,52	c-FLIP	0,6	caspase-8	c-FLIP	841	8837	Gene	Gene	activation|amod|START_ENTITY regulator|nmod|activation regulator|nsubj|END_ENTITY	c-FLIP -LRB- L -RRB- is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis .
11384965	0	caspase-8	47,56	c-Fos	82,87	caspase-8	c-Fos	841	2353	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Fas-associated_death_domain_protein -LRB- FADD -RRB- and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- via a FLICE inhibitory protein -LRB- FLIP -RRB- - regulated pathway .
9733516	0	caspase-8	88,97	c-IAP1	58,64	caspase-8	c-IAP1	841	329	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	NF-kappaB antiapoptosis : induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation .
17989734	0	caspase-8	119,128	cIAP2	155,160	caspase-8	cIAP2	841	330	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2 .
20675131	0	caspase-8	83,92	caspase-3	93,102	caspase-8	caspase-3	841	836	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8 / caspase-3 activation .
21984154	0	caspase-8	106,115	caspase-3	95,104	caspase-8	caspase-3	12370(Tax:10090)	12367(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Effects of Mycobacterium_tuberculosis on apoptosis of mouse dendritic cells and activation of caspase-3 , caspase-8 -RSB- .
18467326	0	caspase-8	100,109	caspase-9	26,35	caspase-8	caspase-9	12370(Tax:10090)	12371(Tax:10090)	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|casein_kinase_2 casein_kinase_2|amod|END_ENTITY	Phosphorylation of murine caspase-9 by the protein kinase casein_kinase_2 regulates its cleavage by caspase-8 .
21314204	0	caspase-8	33,42	caspase-9	15,24	caspase-8	caspase-9	841	842	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast_cancer cells .
23443079	0	caspase-8	110,119	caspase-9	100,109	caspase-8	caspase-9	841	842	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Ginsenoside_Rh2 induces human hepatoma cell apoptosisvia bax/bak triggered cytochrome_C release and caspase-9 / caspase-8 activation .
15763985	0	caspase-8	98,107	cytochrome_c	142,154	caspase-8	cytochrome c	841	54205	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Upon drug-induced apoptosis expression of prostate-apoptosis-response-gene-4 promotes cleavage of caspase-8 , bid and mitochondrial release of cytochrome_c .
26662956	0	caspase-8	138,147	death_receptor-5	112,128	caspase-8	death receptor-5	841	8795	Gene	Gene	caspase-3|amod|START_ENTITY caspase-3|amod|END_ENTITY	Synergistic effect of fisetin combined with sorafenib in human cervical_cancer HeLa cells through activation of death_receptor-5 mediated caspase-8 / caspase-3 and the mitochondria-dependent apoptotic pathway .
10490833	0	caspase-8	57,66	lck	20,23	caspase-8	lck	841	3932	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation .
11260720	0	caspase-8	61,70	p35	71,74	caspase-8	p35	841	3592	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Covalent inhibition revealed by the crystal structure of the caspase-8 / p35 complex .
10988287	0	caspase-8	19,28	p53	81,84	caspase-8	p53	841	7157	Gene	Gene	role|nmod|START_ENTITY triggered|nsubj|role triggered|nmod|END_ENTITY	Essential role for caspase-8 in transcription-independent apoptosis triggered by p53 .
11896437	0	caspase-8	79,88	p53	10,13	caspase-8	p53	841	7157	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells : role of caspase-8 and mitochondria .
11896437	0	caspase-8	79,88	p53	46,49	caspase-8	p53	841	7157	Gene	Gene	role|nmod|START_ENTITY p53|dep|role p53|acl|induced induced|dobj|sensitization sensitization|nmod|cells cells|compound|END_ENTITY	Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells : role of caspase-8 and mitochondria .
19706414	0	caspase-8	41,50	p53	102,105	caspase-8	p53	841	7157	Gene	Gene	modulates|amod|START_ENTITY osteopontin|nmod|modulates cleavage|nmod|osteopontin hypoxia/reoxygenation|nsubj|cleavage hypoxia/reoxygenation|nmod|END_ENTITY	Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53 .
20060030	0	caspase-8	66,75	p53	44,47	caspase-8	p53	841	7157	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Indole-3-carbinol induces apoptosis through p53 and activation of caspase-8 pathway in lung_cancer A549 cells .
11245427	0	caspase-8	145,154	tumor_necrosis_factor-related_apoptosis-inducing_ligand	14,69	caspase-8	tumor necrosis factor-related apoptosis-inducing ligand	841	8743	Gene	Gene	expression|amod|START_ENTITY apoptosis|nmod|expression END_ENTITY|dep|apoptosis	Resistance to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression .
24249161	0	caspase-9	79,88	APAF-1	72,78	caspase-9	APAF-1	842	317	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	MicroRNA-23a antisense enhances 5-fluorouracil chemosensitivity through APAF-1 / caspase-9 apoptotic pathway in colorectal_cancer cells .
10940292	0	caspase-9	22,31	Apaf-1	77,83	caspase-9	Apaf-1	842	317	Gene	Gene	activation|amod|START_ENTITY promotes|dobj|activation promotes|advcl|inducing inducing|dobj|nucleotide nucleotide|amod|END_ENTITY	Cytochrome_c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 .
11753565	0	caspase-9	68,77	Apaf-1	17,23	caspase-9	Apaf-1	58918(Tax:10116)	78963(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY precedes|dobj|activation Formation|parataxis|precedes Formation|nmod|END_ENTITY	Formation of the Apaf-1 / cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal_death .
11904389	0	caspase-9	34,43	Apaf-1	56,62	caspase-9	Apaf-1	842	317	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Oligomerization and activation of caspase-9 , induced by Apaf-1 CARD .
12506111	0	caspase-9	25,34	Apaf-1	18,24	caspase-9	Apaf-1	842	317	Gene	Gene	apoptosome|amod|START_ENTITY Regulation|dep|apoptosome Regulation|nmod|END_ENTITY	Regulation of the Apaf-1 / caspase-9 apoptosome by caspase-3 and XIAP .
12605597	0	caspase-9	52,61	Apaf-1	45,51	caspase-9	Apaf-1	842	317	Gene	Gene	apoptosome|amod|START_ENTITY END_ENTITY|dep|apoptosome	Nitric_oxide donors inhibit formation of the Apaf-1 / caspase-9 apoptosome and activation of caspases .
14993223	0	caspase-9	140,149	Apaf-1	133,139	caspase-9	Apaf-1	842	317	Gene	Gene	apoptosome|amod|START_ENTITY complex|dep|apoptosome END_ENTITY|dep|complex	Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1 / caspase-9 apoptosome complex .
15253891	0	caspase-9	65,74	Apaf-1	58,64	caspase-9	Apaf-1	58918(Tax:10116)	78963(Tax:10116)	Gene	Gene	apoptosome|amod|START_ENTITY apoptosome|compound|END_ENTITY	Taurine inhibits apoptosis by preventing formation of the Apaf-1 / caspase-9 apoptosome .
15703181	0	caspase-9	27,36	Apaf-1	51,57	caspase-9	Apaf-1	842	317	Gene	Gene	activation|amod|START_ENTITY kinase|dobj|activation kinase|nmod|downstream downstream|compound|END_ENTITY	Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome_c .
19238172	0	caspase-9	26,35	Apaf-1	103,109	caspase-9	Apaf-1	842	317	Gene	Gene	modification|nmod|START_ENTITY facilitates|nsubj|modification facilitates|nmod|END_ENTITY	Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1 .
21659556	0	caspase-9	103,112	Apaf-1	131,137	caspase-9	Apaf-1	426970(Tax:9031)	417926(Tax:9031)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine : activation of caspase-9 in the absence of Apaf-1 .
25313070	0	caspase-9	26,35	Apaf-1	54,60	caspase-9	Apaf-1	842	317	Gene	Gene	activation|amod|START_ENTITY determinants|nmod|activation determinants|nmod|apoptosome apoptosome|compound|END_ENTITY	Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome .
9390557	0	caspase-9	52,61	Apaf-1	45,51	caspase-9	Apaf-1	842	317	Gene	Gene	initiates|amod|START_ENTITY formation|dep|initiates formation|nmod|END_ENTITY	Cytochrome_c and dATP-dependent formation of Apaf-1 / caspase-9 complex initiates an apoptotic protease cascade .
11677110	0	caspase-9	41,50	CASP9	52,57	caspase-9	CASP9	842	842	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The potential tumour suppressor role for caspase-9 -LRB- CASP9 -RRB- in the childhood malignancy , neuroblastoma .
10940292	0	caspase-9	22,31	Cytochrome_c	0,12	caspase-9	Cytochrome c	842	54205	Gene	Gene	activation|amod|START_ENTITY promotes|dobj|activation promotes|nsubj|END_ENTITY	Cytochrome_c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1 .
11600533	0	caspase-9	50,59	Cytochrome_c	0,12	caspase-9	Cytochrome c	842	54205	Gene	Gene	activation|acl|START_ENTITY upstream|nmod|activation induced|advmod|upstream induced|nsubjpass|release release|amod|END_ENTITY	Cytochrome_c release is upstream to activation of caspase-9 , caspase-8 , and caspase-3 in the enhanced apoptosis of anaplastic_thyroid_cancer cells induced by manumycin and paclitaxel .
9390557	0	caspase-9	52,61	Cytochrome_c	0,12	caspase-9	Cytochrome c	842	54205	Gene	Gene	initiates|amod|START_ENTITY formation|dep|initiates formation|amod|END_ENTITY	Cytochrome_c and dATP-dependent formation of Apaf-1 / caspase-9 complex initiates an apoptotic protease cascade .
24338711	0	caspase-9	15,24	EMP1	0,4	caspase-9	EMP1	842	2012	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	EMP1 regulates caspase-9 and VEGFC expression and suppresses prostate_cancer cell proliferation and invasion .
20673794	0	caspase-9	75,84	PARP	86,90	caspase-9	PARP	842	1302	Gene	Gene	release|amod|START_ENTITY release|dep|END_ENTITY	Typhonium_flagelliforme induces apoptosis in CEMss cells via activation of caspase-9 , PARP cleavage and cytochrome_c release : its activation coupled with G0/G1 phase cell cycle arrest .
15674327	0	caspase-9	88,97	Raf-1	119,124	caspase-9	Raf-1	12371(Tax:10090)	110157(Tax:10090)	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1 .
11973426	0	caspase-9	36,45	caspase-3	84,93	caspase-9	caspase-3	58918(Tax:10116)	25402(Tax:10116)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|dep|implications implications|nmod|role role|acl|mediating mediating|dobj|activation activation|amod|END_ENTITY	Cloning and characterization of rat caspase-9 : implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral_ischemia .
12437970	0	caspase-9	48,57	caspase-3	58,67	caspase-9	caspase-3	842	836	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Ceramide induces neuronal apoptosis through the caspase-9 / caspase-3 pathway .
12506111	0	caspase-9	25,34	caspase-3	49,58	caspase-9	caspase-3	842	836	Gene	Gene	apoptosome|amod|START_ENTITY apoptosome|nmod|END_ENTITY	Regulation of the Apaf-1 / caspase-9 apoptosome by caspase-3 and XIAP .
22944165	0	caspase-9	127,136	caspase-3	137,146	caspase-9	caspase-3	842	836	Gene	Gene	down-regulation|nmod|START_ENTITY induced|nmod|down-regulation O|dep|induced -RSB-|nsubj|O -RSB-|amod|END_ENTITY	-LSB- Atorvastatin inhibits the H ___ O - induced apoptosis of human vascular endothelial cells through a down-regulation of cleaved caspase-9 / caspase-3 -RSB- .
24563336	0	caspase-9	91,100	caspase-3	81,90	caspase-9	caspase-3	842	836	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Oxymatrine triggers apoptosis by regulating Bcl-2 family proteins and activating caspase-3 / caspase-9 pathway in human leukemia HL-60 cells .
25891909	0	caspase-9	142,151	caspase-3	152,161	caspase-9	caspase-3	842	836	Gene	Gene	cleavage|amod|START_ENTITY cleavage|amod|END_ENTITY	Photoactivation of hypericin decreases the viability of RINm5F_insulinoma cells through reduction of JNK/ERK phosphorylation and elevation of caspase-9 / caspase-3 cleavage and Bax-to-Bcl-2 ratio .
26182357	0	caspase-9	142,151	caspase-3	152,161	caspase-9	caspase-3	842	836	Gene	Gene	cleavage|amod|START_ENTITY cleavage|amod|END_ENTITY	Photoactivation of hypericin decreases the viability of RINm5F_insulinoma cells through reduction in JNK/ERK phosphorylation and elevation of caspase-9 / caspase-3 cleavage and Bax-to-Bcl-2 ratio .
18467326	0	caspase-9	26,35	caspase-8	100,109	caspase-9	caspase-8	12371(Tax:10090)	12370(Tax:10090)	Gene	Gene	casein_kinase_2|amod|START_ENTITY Phosphorylation|nmod|casein_kinase_2 regulates|nsubj|Phosphorylation regulates|advcl|END_ENTITY	Phosphorylation of murine caspase-9 by the protein kinase casein_kinase_2 regulates its cleavage by caspase-8 .
21314204	0	caspase-9	15,24	caspase-8	33,42	caspase-9	caspase-8	842	841	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Involvement of caspase-9 but not caspase-8 in the anti-apoptotic effects of estradiol and 4-OH-Estradiol in MCF-7 human breast_cancer cells .
23443079	0	caspase-9	100,109	caspase-8	110,119	caspase-9	caspase-8	842	841	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Ginsenoside_Rh2 induces human hepatoma cell apoptosisvia bax/bak triggered cytochrome_C release and caspase-9 / caspase-8 activation .
10393175	0	caspase-9	64,73	cytochrome_c	8,20	caspase-9	cytochrome c	842	54205	Gene	Gene	activation|amod|START_ENTITY hydrolysis|nmod|activation hydrolysis|nsubj|Role Role|nmod|END_ENTITY	Role of cytochrome_c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis .
10673981	0	caspase-9	105,114	cytochrome_c	66,78	caspase-9	cytochrome c	842	54205	Gene	Gene	flavonoids|acl|START_ENTITY flavonoids|nmod|release release|amod|END_ENTITY	Induction of apoptosis by apigenin and related flavonoids through cytochrome_c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells .
11312805	0	caspase-9	114,123	cytochrome_c	75,87	caspase-9	cytochrome c	842	54205	Gene	Gene	Induction|acl|START_ENTITY Induction|nmod|release release|amod|END_ENTITY	Induction of apoptosis by the oolong tea polyphenol_theasinensin_A through cytochrome_c release and activation of caspase-9 and caspase-3 in human U937 cells .
11577712	0	caspase-9	48,57	cytochrome_c	114,126	caspase-9	cytochrome c	842	54205	Gene	Gene	activation|acl|START_ENTITY induction|dep|activation induction|dep|CAD CAD|nmod|release release|nmod|END_ENTITY	Apoptosis induction by T-2_toxin : activation of caspase-9 , caspase-3 , and DFF-40 / CAD through cytosolic release of cytochrome_c in HL-60 cells .
12954616	0	caspase-9	48,57	cytochrome_c	86,98	caspase-9	cytochrome c	842	54205	Gene	Gene	independent|advcl|START_ENTITY mediated|xcomp|independent mediated|nmod|cells cells|dep|model model|nmod|resistance resistance|amod|END_ENTITY	UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells : a model for cytochrome_c resistance .
14972545	0	caspase-9	100,109	cytochrome_c	87,99	caspase-9	cytochrome c	842	54205	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Avian_encephalomyelitis_virus nonstructural protein 2C induces apoptosis by activating cytochrome_c / caspase-9 pathway .
15008459	0	caspase-9	116,125	cytochrome_c	103,115	caspase-9	cytochrome c	842	54205	Gene	Gene	apoptosome|amod|START_ENTITY apoptosome|amod|dependent dependent|nmod|/ /|amod|END_ENTITY	Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation , dependent on the cytochrome_c / caspase-9 apoptosome .
15703181	0	caspase-9	27,36	cytochrome_c	72,84	caspase-9	cytochrome c	842	54205	Gene	Gene	activation|amod|START_ENTITY kinase|dobj|activation kinase|nmod|downstream downstream|nmod|END_ENTITY	Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome_c .
20227384	0	caspase-9	107,116	cytochrome_c	40,52	caspase-9	cytochrome c	842	54205	Gene	Gene	activation|amod|START_ENTITY blocking|dobj|activation signaling|advcl|blocking apoptosis|acl|signaling play|nmod|apoptosis END_ENTITY|acl|play	Nitration of tyrosine 74 prevents human cytochrome_c to play a key role in apoptosis signaling by blocking caspase-9 activation .
19586613	0	caspase-9	50,59	p38alpha	0,8	caspase-9	p38alpha	842	1432	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	p38alpha - and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress .
10764577	0	caspase-activated_DNase	31,54	CAD	17,20	caspase-activated DNase	CAD	1677	1677	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|domain domain|compound|END_ENTITY	Structure of the CAD domain of caspase-activated_DNase and interaction with the CAD domain of its inhibitor .
10764577	0	caspase-activated_DNase	31,54	CAD	80,83	caspase-activated DNase	CAD	1677	1677	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|domain domain|compound|END_ENTITY	Structure of the CAD domain of caspase-activated_DNase and interaction with the CAD domain of its inhibitor .
15940676	0	caspase-activated_DNase	46,69	CAD	32,35	caspase-activated DNase	CAD	1677	1677	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Amyloid fibril formation by the CAD domain of caspase-activated_DNase .
16121124	0	caspase-activated_DNase	47,70	Caspase-3	0,9	caspase-activated DNase	Caspase-3	1677	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Caspase-3 cleavage and nuclear localization of caspase-activated_DNase in human temporal_lobe_epilepsy .
12738667	0	caspase-activated_DNase	28,51	Heat_shock_protein_70	0,21	caspase-activated DNase	Heat shock protein 70	1677	3308	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Heat_shock_protein_70 binds caspase-activated_DNase and enhances its activity in TCR-stimulated T cells .
10713130	0	caspase-activated_DNase	49,72	caspase-activated_DNase	77,100	caspase-activated DNase	caspase-activated DNase	13368(Tax:10090)	13368(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Specific chaperone-like activity of inhibitor of caspase-activated_DNase for caspase-activated_DNase .
10713130	0	caspase-activated_DNase	77,100	caspase-activated_DNase	49,72	caspase-activated DNase	caspase-activated DNase	13368(Tax:10090)	13368(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Specific chaperone-like activity of inhibitor of caspase-activated_DNase for caspase-activated_DNase .
23229555	0	caspase-activated_deoxyribonuclease	66,101	DNAS1L3	148,155	caspase-activated deoxyribonuclease	DNAS1L3	1677	1776	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated_deoxyribonuclease and the poly -LRB- ADP-ribose -RRB- _ polymerase-regulated DNAS1L3 , an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis .
12527914	0	caspase1	173,181	p53	138,141	caspase1	p53	834	7157	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21 -LRB- waf1/cip1 -RRB- .
16817903	0	caspase_1	15,24	Ipaf	43,47	caspase 1	Ipaf	834	58484	Gene	Gene	Involvement|nmod|START_ENTITY END_ENTITY|nsubj|Involvement	Involvement of caspase_1 and its activator Ipaf upstream of mitochondrial events in apoptosis .
25300915	0	caspase_2	76,85	HMGA2	35,40	caspase 2	HMGA2	835	8091	Gene	Gene	apoptosis|nmod|START_ENTITY role|nmod|apoptosis role|nmod|END_ENTITY	A novel anti-proliferative role of HMGA2 in induction of apoptosis through caspase_2 in primary human fibroblast cells .
12684678	0	caspase_3	9,18	Akt	29,32	caspase 3	Akt	836	207	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Inactive caspase_3 activates Akt in human leukemia cells susceptible or resistant to apoptosis induced by phorbol_ester .
10203579	0	caspase_3	47,56	Bcl-2	0,5	caspase 3	Bcl-2	836	596	Gene	Gene	activation|amod|START_ENTITY protects|nmod|activation protects|nsubj|END_ENTITY	Bcl-2 protects against beta-lapachone-mediated caspase_3 activation and apoptosis in human myeloid_leukemia -LRB- HL-60 -RRB- cells .
16111802	0	caspase_3	141,150	Bcl-2	119,124	caspase 3	Bcl-2	836	596	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase_3 activity .
20132233	0	caspase_3	118,127	Bcl-2	79,84	caspase 3	Bcl-2	836	596	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|dobj|activation	Erythropoietin inhibits gamma-irradiation-induced apoptosis by upregulation of Bcl-2 and decreasing the activation of caspase_3 in human UT-7 / erythropoietin cell line .
21910070	0	caspase_3	135,144	Bcl-2	104,109	caspase 3	Bcl-2	836	596	Gene	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Pien Tze Huang induced apoptosis in human colon_cancer HT-29 cells is associated with regulation of the Bcl-2 family and activation of caspase_3 .
10847548	0	caspase_3	32,41	CPP32	42,47	caspase 3	CPP32	836	836	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of the pro-apoptotic caspase_3 / CPP32 in cutaneous basal and squamous_cell_carcinomas .
9363747	0	caspase_3	25,34	CPP32	36,41	caspase 3	CPP32	25402(Tax:10116)	25402(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Apoptotic cell death and caspase_3 -LRB- CPP32 -RRB- activation induced by calcium ionophore at low concentrations and their prevention by nerve growth factor in PC12 cells .
9512515	0	caspase_3	26,35	CPP32	36,41	caspase 3	CPP32	12367(Tax:10090)	12367(Tax:10090)	Gene	Gene	contribution|nmod|START_ENTITY contribution|dep|END_ENTITY	Essential contribution of caspase_3 / CPP32 to apoptosis and its associated nuclear changes .
12151338	0	caspase_3	57,66	Cdc6	26,30	caspase 3	Cdc6	836	990	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Human replication protein Cdc6 is selectively cleaved by caspase_3 during apoptosis .
25176410	0	caspase_3	23,32	FANCD2	0,6	caspase 3	FANCD2	836	2177	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	FANCD2 is a target for caspase_3 during DNA damage-induced apoptosis .
19355923	0	caspase_3	123,132	FOXO3a	34,40	caspase 3	FOXO3a	836	2309	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	The forkhead transcription factor FOXO3a controls microglial inflammatory activation and eventual apoptotic_injury through caspase_3 .
19619516	0	caspase_3	65,74	NFL	89,92	caspase 3	NFL	12367(Tax:10090)	18039(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Cytosolic TDP-43 expression following axotomy is associated with caspase_3 activation in NFL - / - mice : support for a role for TDP-43 in the physiological response to neuronal_injury .
11432986	0	caspase_3	17,26	PKB	63,66	caspase 3	PKB	836	207	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Lithium inhibits caspase_3 activation and dephosphorylation of PKB and GSK3 induced by K + deprivation in cerebellar granule cells .
18439040	0	caspase_3	19,28	Rad51	41,46	caspase 3	Rad51	836	5888	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Radiation enhances caspase_3 cleavage of Rad51 in BRCA2-defective cells .
11414450	0	caspase_3	18,27	TNF-alpha	0,9	caspase 3	TNF-alpha	836	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	TNF-alpha induces caspase_3 -LRB- CPP_32 -RRB- dependent apoptosis in human cholangiocarcinoma cell line .
12815278	0	caspase_3	30,39	alpha_II-spectrin	57,74	caspase 3	alpha II-spectrin	836	6709	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Identification of the primary caspase_3 cleavage site in alpha_II-spectrin during apoptosis .
22686277	0	caspase_3	100,109	b-catenin	84,93	caspase 3	b-catenin	836	1499	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical investigation of cell cycle and apoptosis regulators -LRB- survivin , b-catenin , p53 , caspase_3 -RRB- in canine appendicular_osteosarcoma .
21290413	0	caspase_3	47,56	caspase_8	37,46	caspase 3	caspase 8	12367(Tax:10090)	12370(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Trimethyltin initially activates the caspase_8 / caspase_3 pathway for damaging the primary cultured cortical neurons derived from embryonic mice .
10518027	0	caspase_3	87,96	cytochrome_c	41,53	caspase 3	cytochrome c	836	54205	Gene	Gene	activation|amod|START_ENTITY precedes|dobj|activation mitochondria|acl:relcl|precedes END_ENTITY|nmod|mitochondria	NO induces a cGMP-independent release of cytochrome_c from mitochondria which precedes caspase_3 activation in insulin producing RINm5F cells .
12120809	0	caspase_3	139,148	cytochrome_c	108,120	caspase 3	cytochrome c	836	54205	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Induction of apoptosis in a human erythroleukemic cell line K562 by tylophora alkaloids involves release of cytochrome_c and activation of caspase_3 .
15533592	0	caspase_3	112,121	cytochrome_c	90,102	caspase 3	cytochrome c	836	54205	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Beauvericin induces cytotoxic effects in human acute_lymphoblastic_leukemia cells through cytochrome_c release , caspase_3 activation : the causative role of calcium .
17588735	0	caspase_3	129,138	cytochrome_c	86,98	caspase 3	cytochrome c	836	54205	Gene	Gene	transferred|nmod|START_ENTITY transferred|nmod|B B|compound|END_ENTITY	Cell death signal by glycine - and proline-rich plant glycoprotein is transferred from cytochrome_c and nuclear factor kappa B to caspase_3 in Hep3B cells .
20132233	0	caspase_3	118,127	erythropoietin	142,156	caspase 3	erythropoietin	836	2056	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	Erythropoietin inhibits gamma-irradiation-induced apoptosis by upregulation of Bcl-2 and decreasing the activation of caspase_3 in human UT-7 / erythropoietin cell line .
11912174	0	caspase_3	80,89	focal_adhesion_kinase	115,136	caspase 3	focal adhesion kinase	836	5747	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase_3 activity and cleavage of focal_adhesion_kinase .
23661706	0	caspase_4	82,91	Transmembrane_Protein_214	0,25	caspase 4	Transmembrane Protein 214	837	54867	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Transmembrane_Protein_214 -LRB- TMEM214 -RRB- mediates endoplasmic reticulum stress-induced caspase_4 enzyme activation and apoptosis .
11438643	0	caspase_6	60,69	AP-2alpha	21,30	caspase 6	AP-2alpha	12368(Tax:10090)	21418(Tax:10090)	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Transcription factor AP-2alpha is preferentially cleaved by caspase_6 and degraded by proteasome during tumor_necrosis_factor_alpha-induced apoptosis in breast_cancer cells .
19323650	0	caspase_7	6,15	SREBP-1	44,51	caspase 7	SREBP-1	840	6720	Gene	Gene	controlled|nsubjpass|START_ENTITY controlled|nmod|END_ENTITY	Human caspase_7 is positively controlled by SREBP-1 and SREBP-2 .
21691071	0	caspase_8	31,40	Caspase_3	0,9	caspase 8	Caspase 3	841	836	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Caspase_3 is activated through caspase_8 instead of caspase_9 during H2O2-induced apoptosis in HeLa cells .
21235526	0	caspase_8	16,25	FLIP	0,4	caspase 8	FLIP	12370(Tax:10090)	12633(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	FLIP -LRB- L -RRB- induces caspase_8 activity in the absence of interdomain caspase_8 cleavage and alters substrate specificity .
20951133	0	caspase_8	58,67	TNF-related_apoptosis-inducing_ligand	75,112	caspase 8	TNF-related apoptosis-inducing ligand	841	8743	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Cellular_inhibitor_of_apoptosis_1 -LRB- cIAP-1 -RRB- degradation by caspase_8 during TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis .
21290413	0	caspase_8	37,46	caspase_3	47,56	caspase 8	caspase 3	12370(Tax:10090)	12367(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Trimethyltin initially activates the caspase_8 / caspase_3 pathway for damaging the primary cultured cortical neurons derived from embryonic mice .
25506265	0	caspase_8	51,60	death_receptor_5	16,32	caspase 8	death receptor 5	841	8795	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of death_receptor_5 and activation of caspase_8 / 3 play a critical role in ergosterol_peroxide induced apoptosis in DU 145 prostate_cancer cells .
17766243	0	caspase_8	15,24	multiple_endocrine_neoplasia_type_1	51,86	caspase 8	multiple endocrine neoplasia type 1	12370(Tax:10090)	17283(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Menin-mediated caspase_8 expression in suppressing multiple_endocrine_neoplasia_type_1 .
19016842	0	caspase_9	22,31	DYRK1A	0,6	caspase 9	DYRK1A	842	1859	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	DYRK1A phosphorylates caspase_9 at an inhibitory site and is potently inhibited in human cells by harmine .
14576769	0	caspase_9	35,44	Smac	74,78	caspase 9	Smac	842	56616	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Retinoid-related molecules require caspase_9 for the effective release of Smac and the rapid induction of apoptosis .
17437405	0	caspase_9	91,100	XIAP	21,25	caspase 9	XIAP	842	331	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|dep|inhibition	Caspase_3 attenuates XIAP -LRB- X-linked inhibitor of apoptosis protein -RRB- - mediated inhibition of caspase_9 .
15642122	0	caspase_9	129,138	endonuclease_G	168,182	caspase 9	endonuclease G	842	2021	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Saturated free fatty_acids and apoptosis in microvascular mesangial cells : palmitate activates pro-apoptotic signaling involving caspase_9 and mitochondrial release of endonuclease_G .
15644269	0	caspase_activated_DNase	90,113	TP53	75,79	caspase activated DNase	TP53	1677	7157	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Modulation of age at_onset of Huntington_disease patients by variations in TP53 and human caspase_activated_DNase -LRB- hCAD -RRB- genes .
15644269	0	caspase_activated_DNase	90,113	hCAD	115,119	caspase activated DNase	hCAD	1677	730249	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Modulation of age at_onset of Huntington_disease patients by variations in TP53 and human caspase_activated_DNase -LRB- hCAD -RRB- genes .
20298285	0	caspase_activating_recruitment_domain_15	52,92	CARD_15	94,101	caspase activating recruitment domain 15	CARD 15	64127	64127	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Blau_syndrome-associated mutations in exon 4 of the caspase_activating_recruitment_domain_15 -LRB- CARD_15 -RRB- gene are not found in ethnic Danes with sarcoidosis .
11709351	0	cat	100,103	chloramphenicol_acetyltransferase	65,98	cat	chloramphenicol acetyltransferase	8319152(Tax:562)	8319152(Tax:562)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chloramphenicol-sensitive Escherichia_coli_strain expressing the chloramphenicol_acetyltransferase -LRB- cat -RRB- gene .
24167160	0	catalase	24,32	AMPK	0,4	catalase	AMPK	847	5562	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	AMPK and FoxO1 regulate catalase expression in hypoxic pulmonary arterial smooth muscle .
26530238	0	catalase	9,17	APX	50,53	catalase	APX	543990(Tax:4081)	778224(Tax:4081)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Roles of catalase -LRB- CAT -RRB- and ascorbate peroxidase -LRB- APX -RRB- genes in stress response of eggplant -LRB- Solanum melongena L. -RRB- against Cu -LRB- +2 -RRB- and Zn -LRB- +2 -RRB- heavy metal stresses .
18073138	0	catalase	22,30	Adipose	0,7	catalase	Adipose	12359(Tax:10090)	230796(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Adipose expression of catalase is regulated via a novel remote PPARgamma-responsive region .
21660462	0	catalase	29,37	Angiotensin_II	0,14	catalase	Angiotensin II	847	183	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Angiotensin_II downregulates catalase expression and activity in vascular adventitial fibroblasts through an AT1R/ERK1/2-dependent pathway .
17728292	0	catalase	55,63	AtMEK1	0,6	catalase	AtMEK1	829661(Tax:3702)	828713(Tax:3702)	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	AtMEK1 mediates stress-induced gene expression of CAT1 catalase by triggering H2O2 production in Arabidopsis .
23868633	0	catalase	23,31	CAT	33,36	catalase	CAT	847	847	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No association between catalase -LRB- CAT -RRB- gene polymorphisms and susceptibility to vitiligo in a Turkish population .
25139332	0	catalase	70,78	CAT	80,83	catalase	CAT	847	847	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between the 389C > T polymorphism -LRB- rs769217 -RRB- in the catalase -LRB- CAT -RRB- gene and the risk of vitiligo : An update by meta-analysis .
6252821	0	catalase	23,31	CAT	33,36	catalase	CAT	847	847	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regional assignment of catalase -LRB- CAT -RRB- gene to band 11p13 .
8639268	0	catalase	153,161	Cas-1	168,173	catalase	Cas-1	12359(Tax:10090)	12359(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Distinct mRNA-binding proteins interacting with short repeat sequences of the 3 ' UTR may be involved in the post-transcriptional regulation of the mouse catalase gene , Cas-1 .
3526334	0	catalase	19,27	Cat2	29,33	catalase	Cat2	542230(Tax:4577)	542230(Tax:4577)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Spatial pattern of catalase -LRB- Cat2 -RRB- gene activation in scutella during postgerminative development in maize .
10617683	0	catalase	46,54	HNF-1alpha	12,22	catalase	HNF-1alpha	12359(Tax:10090)	21405(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	The role of HNF-1alpha in controlling hepatic catalase activity .
10318800	0	catalase	28,36	NADPH	40,45	catalase	NADPH	847	1666	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|nmod|END_ENTITY	Mechanisms of protection of catalase by NADPH .
21976670	0	catalase	29,37	PEX5	0,4	catalase	PEX5	847	5830	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|protein protein|compound|END_ENTITY	PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14 .
15556604	0	catalase	11,19	SHP2	0,4	catalase	SHP2	847	5781	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	SHP2 binds catalase and acquires a hydrogen_peroxide-resistant phosphatase activity via integrin-signaling .
11479230	0	catalase	18,26	Sp1	44,47	catalase	Sp1	847	6667	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the catalase gene promoter by Sp1 , CCAAT-recognizing factors , and a WT1/Egr-related _ factor in hydrogen_peroxide-resistant HP100 cells .
15728537	0	catalase	20,28	TIMP-1	62,68	catalase	TIMP-1	847	7076	Gene	Gene	levels|nmod|START_ENTITY levels|dep|END_ENTITY	Increased levels of catalase and cathepsin_V / L2 but decreased TIMP-1 in keratoconus corneas : evidence that oxidative stress plays a role in this disorder .
21276205	0	catalase	145,153	Vascular_endothelial_growth_factor	0,34	catalase	Vascular endothelial growth factor	24248(Tax:10116)	83785(Tax:10116)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Vascular_endothelial_growth_factor protects post-ganglionic sympathetic neurones from the detrimental effects of hydrogen_peroxide by increasing catalase .
12435514	0	catalase	45,53	catalase	89,97	catalase	catalase	847	847	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Characterisation of the katA gene encoding a catalase and evidence for at least a second catalase activity in Staphylococcus xylosus , bacteria used in food fermentation .
12435514	0	catalase	89,97	catalase	45,53	catalase	catalase	847	847	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Characterisation of the katA gene encoding a catalase and evidence for at least a second catalase activity in Staphylococcus xylosus , bacteria used in food fermentation .
15667946	0	catalase	14,22	cyclooxygenase_2	31,47	catalase	cyclooxygenase 2	847	5743	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Extracellular catalase induces cyclooxygenase_2 , interleukin_8 , and stromelysin genes in primary human chondrocytes .
2827496	0	catalase	55,63	glucose-6-phosphatase	17,38	catalase	glucose-6-phosphatase	24248(Tax:10116)	25634(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats .
1693779	0	catalase	78,86	glycoprotein	53,65	catalase	glycoprotein	847	7306	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Murine and human b locus pigmentation genes encode a glycoprotein -LRB- gp75 -RRB- with catalase activity .
6192633	0	catalase	14,22	tyrosinase	46,56	catalase	tyrosinase	847	7299	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|inactivation inactivation|nmod|END_ENTITY	The effect of catalase on the inactivation of tyrosinase by ascorbic_acid and by cysteine or glutathione .
1848176	0	catalase_T	69,79	CTT1	81,85	catalase T	CTT1	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Negative regulation of transcription of the Saccharomyces_cerevisiae catalase_T -LRB- CTT1 -RRB- gene by cAMP is mediated by a positive control element .
2061315	0	catalase_T	100,110	CTT1	67,71	catalase T	CTT1	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	Heat_shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase_T of Saccharomyces_cerevisiae .
2844525	0	catalase_T	160,170	CTT1	177,181	catalase T	CTT1	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins : a binding site for the HAP1 -LRB- CYP1 -RRB- protein in the UAS region of the yeast catalase_T gene -LRB- CTT1 -RRB- .
8987534	0	catalase_T	124,134	CTT1	136,140	catalase T	CTT1	852979(Tax:4932)	852979(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Recombinant Hansenula_polymorpha as a biocatalyst : coexpression of the spinach glycolate oxidase -LRB- GO -RRB- and the S. _ cerevisiae catalase_T -LRB- CTT1 -RRB- gene .
8268212	0	catalytic_alpha-subunit	59,82	Casein_kinase_II_beta-subunit	0,29	catalytic alpha-subunit	Casein kinase II beta-subunit	34792(Tax:7227)	32132(Tax:7227)	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Casein_kinase_II_beta-subunit inhibits the activity of the catalytic_alpha-subunit in the absence of salt .
11114723	0	catalytic_subunit_of_DNA_polymerase_delta	57,98	pRb	43,46	catalytic subunit of DNA polymerase delta	pRb	7508	5925	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the retinoblastoma protein -LRB- pRb -RRB- with the catalytic_subunit_of_DNA_polymerase_delta -LRB- p125 -RRB- .
17467918	0	catechol-O-methyl-transferase	16,45	COMT	47,51	catechol-O-methyl-transferase	COMT	1312	1312	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Manipulation of catechol-O-methyl-transferase -LRB- COMT -RRB- activity to influence the attenuation of substance seeking behavior , a subtype of Reward_Deficiency_Syndrome -LRB- RDS -RRB- , is dependent upon gene polymorphisms : a hypothesis .
20974455	0	catechol-O-methyl-transferase	26,55	COMT	57,61	catechol-O-methyl-transferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nonsynonimous mutation of catechol-O-methyl-transferase -LRB- COMT -RRB- gene in a patient with temporomandibular_disorder .
593427	0	catechol-O-methyl-transferase	10,39	COMT	41,45	catechol-O-methyl-transferase	COMT	1312	1312	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Effect of catechol-O-methyl-transferase -LRB- COMT -RRB- inhibition on the vascular and metabolic responses to noradrenaline , isoprenaline and sympathetic nerve stimulation in canine subcutaneous adipose tissue .
16505837	0	catechol-O-methyl_transferase	4,33	COMT	35,39	catechol-O-methyl transferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The catechol-O-methyl_transferase -LRB- COMT -RRB- gene as a candidate for psychiatric phenotypes : evidence and lessons .
19603	0	catechol-O-methyl_transferase	35,64	COMT	66,70	catechol-O-methyl transferase	COMT	1312	1312	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Differential influence of block of catechol-O-methyl_transferase -LRB- COMT -RRB- activity and of neuronal uptake on alpha - and beta-adrenergic effects .
19895544	0	catechol-O-methyl_transferase	50,79	COMT	81,85	catechol-O-methyl transferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Study : the lack of significant association of the catechol-O-methyl_transferase -LRB- COMT -RRB- gene polymorphism in violent offenders with mental_retardation .
20643532	0	catechol-O-methyl_transferase	4,33	COMT	35,39	catechol-O-methyl transferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The catechol-O-methyl_transferase -LRB- COMT -RRB- gene and its potential association with schizophrenia : findings from a large German case-control and family-based sample .
21344643	0	catechol-O-methyl_transferase	15,44	COMT	46,50	catechol-O-methyl transferase	COMT	1312	1312	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of catechol-O-methyl_transferase -LRB- COMT -RRB- gene -287 A/G polymorphism with susceptibility to obsessive-compulsive_disorder in Chinese Han population .
24735585	0	catechol-O-methyl_transferase	47,76	Methionine_sulfoxide_reductase	0,30	catechol-O-methyl transferase	Methionine sulfoxide reductase	12846(Tax:10090)	210009(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Methionine_sulfoxide_reductase regulates brain catechol-O-methyl_transferase activity .
10755376	0	catechol-O-methyltransferase	75,103	COMT	105,109	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Gas chromatographic-mass spectrometric procedures for determination of the catechol-O-methyltransferase -LRB- COMT -RRB- activity and for detection of unstable catecholic metabolites in human and rat liver preparations after COMT catalyzed in statu nascendi derivatization using S-adenosylmethionine .
11121178	0	catechol-O-methyltransferase	38,66	COMT	68,72	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Exploratory association study between catechol-O-methyltransferase -LRB- COMT -RRB- high/low enzyme activity polymorphism and hypnotizability .
11489299	0	catechol-O-methyltransferase	60,88	COMT	90,94	catechol-O-methyltransferase	COMT	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effect of intracerebral 6-nitronoradrenaline , an endogenous catechol-O-methyltransferase -LRB- COMT -RRB- inhibitor , on striatal dopamine metabolism in anaesthetised rats .
11706521	0	catechol-O-methyltransferase	30,58	COMT	60,64	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Limited association between a catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and breast_cancer risk in Japan .
11900601	0	catechol-O-methyltransferase	20,48	COMT	50,54	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and severe alcoholic_withdrawal_symptoms in male Japanese alcoholics .
1347500	0	catechol-O-methyltransferase	10,38	COMT	40,44	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human catechol-O-methyltransferase -LRB- COMT -RRB- gene maps to band q11 .2 of chromosome 22 and shows a frequent RFLP with BglI .
15583953	0	catechol-O-methyltransferase	29,57	COMT	59,63	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Negative association between catechol-O-methyltransferase -LRB- COMT -RRB- gene Val158Met polymorphism and persistent tardive_dyskinesia in schizophrenia .
15927391	0	catechol-O-methyltransferase	40,68	COMT	70,74	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Val158Met polymorphism of the human catechol-O-methyltransferase -LRB- COMT -RRB- gene may influence morphine requirements in cancer_pain patients .
16395295	0	catechol-O-methyltransferase	27,55	COMT	57,61	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Significant association of catechol-O-methyltransferase -LRB- COMT -RRB- haplotypes with nicotine_dependence in male and female smokers of two ethnic populations .
16583437	0	catechol-O-methyltransferase	115,143	COMT	145,149	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence for monozygotic twin -LRB- MZ -RRB- discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase -LRB- COMT -RRB- gene .
17963454	0	catechol-O-methyltransferase	51,79	COMT	81,85	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Management of L-Dopa related hyperhomocysteinemia : catechol-O-methyltransferase -LRB- COMT -RRB- inhibitors or B vitamins ?
18189241	0	catechol-O-methyltransferase	21,49	COMT	51,55	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the catechol-O-methyltransferase -LRB- COMT -RRB- gene influence plasma total homocysteine levels .
18424907	0	catechol-O-methyltransferase	30,58	COMT	60,64	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Val158Met polymorphism in the catechol-O-methyltransferase -LRB- COMT -RRB- gene is not associated with tardive_dyskinesia in schizophrenia .
18752908	0	catechol-O-methyltransferase	4,32	COMT	34,38	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The catechol-O-methyltransferase -LRB- COMT -RRB- gene polymorphism and prevalence of uterine fibroids .
19094200	0	catechol-O-methyltransferase	25,53	COMT	55,59	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the catechol-O-methyltransferase -LRB- COMT -RRB- gene and morphine requirements in cancer patients with pain .
19290789	0	catechol-O-methyltransferase	23,51	COMT	53,57	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association studies of catechol-O-methyltransferase -LRB- COMT -RRB- gene with schizophrenia and response to antipsychotic treatment .
19605895	0	catechol-O-methyltransferase	13,41	COMT	43,47	catechol-O-methyltransferase	COMT	445450(Tax:9615)	445450(Tax:9615)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of catechol-O-methyltransferase -LRB- COMT -RRB- genotypes on the prognosis of canine mammary_tumors .
19700233	0	catechol-O-methyltransferase	15,43	COMT	45,49	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and academic achievement in a Chinese cohort .
20374420	0	catechol-O-methyltransferase	16,44	COMT	46,50	catechol-O-methyltransferase	COMT	12846(Tax:10090)	12846(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Distribution of catechol-O-methyltransferase -LRB- COMT -RRB- proteins and enzymatic activities in wild-type and soluble COMT deficient mice .
20434465	0	catechol-O-methyltransferase	41,69	COMT	71,75	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The flexible mind is associated with the catechol-O-methyltransferase -LRB- COMT -RRB- Val158Met polymorphism : evidence for a role of dopamine in the control of task-switching .
20483479	0	catechol-O-methyltransferase	36,64	COMT	66,70	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of association between the catechol-O-methyltransferase -LRB- COMT -RRB- gene and negative symptoms in chronic schizophrenia .
22100850	0	catechol-O-methyltransferase	33,61	COMT	63,67	catechol-O-methyltransferase	COMT	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Complex estrogenic regulation of catechol-O-methyltransferase -LRB- COMT -RRB- in rats .
22180998	0	catechol-O-methyltransferase	62,90	COMT	92,96	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	How to consistently link extraversion and intelligence to the catechol-O-methyltransferase -LRB- COMT -RRB- gene : on defining and measuring psychological phenotypes in neurogenetic research .
22417933	0	catechol-O-methyltransferase	17,45	COMT	47,51	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the catechol-O-methyltransferase -LRB- COMT -RRB- gene and treatment response to venlafaxine_XR in generalized_anxiety_disorder .
22483293	0	catechol-O-methyltransferase	16,44	COMT	46,50	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of the catechol-O-methyltransferase -LRB- COMT -RRB- gene in personality and related psychopathological_disorders .
23178897	0	catechol-O-methyltransferase	4,32	COMT	39,43	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The catechol-O-methyltransferase gene -LRB- COMT -RRB- and cognitive function from childhood through adolescence .
23209597	0	catechol-O-methyltransferase	69,97	COMT	99,103	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigating the genetic basis of theory of mind -LRB- ToM -RRB- : the role of catechol-O-methyltransferase -LRB- COMT -RRB- gene polymorphisms .
23613951	0	catechol-O-methyltransferase	30,58	COMT	60,64	catechol-O-methyltransferase	COMT	24267(Tax:10116)	24267(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Sexually dimorphic effects of catechol-O-methyltransferase -LRB- COMT -RRB- inhibition on dopamine metabolism in multiple brain regions .
23939469	0	catechol-O-methyltransferase	46,74	COMT	76,80	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The associations between the Val158Met in the catechol-O-methyltransferase -LRB- COMT -RRB- gene and the risk of uterine_leiomyoma -LRB- ULM -RRB- .
24040167	0	catechol-O-methyltransferase	105,133	COMT	135,139	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Assessment of cellular estrogenic activity based on estrogen_receptor-mediated reduction of soluble-form catechol-O-methyltransferase -LRB- COMT -RRB- expression in an ELISA-based system .
24762091	0	catechol-O-methyltransferase	52,80	COMT	82,86	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase -LRB- COMT -RRB- gene Val158Met polymorphism .
24955500	0	catechol-O-methyltransferase	42,70	COMT	72,76	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Perceived stress during pregnancy and the catechol-O-methyltransferase -LRB- COMT -RRB- rs165599 polymorphism impacts on childhood IQ .
24956262	0	catechol-O-methyltransferase	24,52	COMT	54,58	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between the catechol-O-methyltransferase -LRB- COMT -RRB- Val158Met polymorphism and manual aiming control in healthy subjects .
25963102	0	catechol-O-methyltransferase	40,68	COMT	70,74	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotype status of the dopamine-related catechol-O-methyltransferase -LRB- COMT -RRB- gene corresponds with desirability of `` unhealthy '' foods .
26450530	0	catechol-O-methyltransferase	20,48	COMT	50,54	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Fetal Val108/158Met catechol-O-methyltransferase -LRB- COMT -RRB- polymorphism and placental COMT activity are associated with the development of preeclampsia .
7172441	0	catechol-O-methyltransferase	76,104	COMT	106,110	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Radioenzymatic assay of plasma adrenaline and noradrenaline : evidence for a catechol-O-methyltransferase -LRB- COMT -RRB- inhibiting factor associated with essential hypertension .
8615170	0	catechol-O-methyltransferase	11,39	COMT	41,45	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Effects of catechol-O-methyltransferase -LRB- COMT -RRB- inhibition on the pharmacokinetics of L-DOPA .
8950414	0	catechol-O-methyltransferase	41,69	COMT	71,75	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a BglI polymorphism of catechol-O-methyltransferase -LRB- COMT -RRB- gene , and association study with schizophrenia .
9159741	0	catechol-O-methyltransferase	24,52	COMT	54,58	catechol-O-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	G/A1947 polymorphism in catechol-O-methyltransferase -LRB- COMT -RRB- gene in Parkinson 's _ disease .
9365014	0	catechol-O-methyltransferase	129,157	COMT	159,163	catechol-O-methyltransferase	COMT	712548(Tax:9544)	712548(Tax:9544)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Cerebral 6 - -LSB- 18F -RSB- fluoro-L-DOPA uptake in rhesus_monkey : pharmacological influence of aromatic_amino_acid decarboxylase -LRB- AAAD -RRB- and catechol-O-methyltransferase -LRB- COMT -RRB- inhibition .
6580988	0	catechol-O-methyltransferase	49,77	phenol_sulfotransferase	9,32	catechol-O-methyltransferase	phenol sulfotransferase	1312	6817	Gene	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Platelet phenol_sulfotransferase and erythrocyte catechol-O-methyltransferase activities : correlation with methyldopa metabolism .
23219927	0	catechol-o-methyl_transferase	71,100	COMT	102,106	catechol-o-methyl transferase	COMT	1312	1312	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Prefrontal_white_matter_impairment in substance users depends upon the catechol-o-methyl_transferase -LRB- COMT -RRB- val158met polymorphism .
6343177	0	catechol-o-methyl_transferase	33,62	COMT	64,68	catechol-o-methyl transferase	COMT	1312	1312	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunoperoxidase localization of catechol-o-methyl_transferase -LRB- COMT -RRB- in human breast_cancer .
10898913	0	catechol-o-methyltransferase	58,86	COMT	88,92	catechol-o-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between the functional variant of the catechol-o-methyltransferase -LRB- COMT -RRB- gene and early-onset alcoholism associated with severe antisocial_behavior .
11054777	0	catechol-o-methyltransferase	140,168	COMT	170,174	catechol-o-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Long forms of the dopamine receptor -LRB- DRD4 -RRB- gene VNTR are more prevalent in substance abusers : no interaction with functional alleles of the catechol-o-methyltransferase -LRB- COMT -RRB- gene .
15124004	0	catechol-o-methyltransferase	16,44	COMT	46,50	catechol-o-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants in the catechol-o-methyltransferase -LRB- COMT -RRB- gene are associated with schizophrenia in Irish high-density families .
22972758	0	catechol-o-methyltransferase	13,41	COMT	43,47	catechol-o-methyltransferase	COMT	1312	1312	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Study of the catechol-o-methyltransferase -LRB- COMT -RRB- gene with high aggression in children .
24716406	0	catechol-o-methyltransferase	14,42	COMT	44,48	catechol-o-methyltransferase	COMT	1312	1312	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of catechol-o-methyltransferase -LRB- COMT -RRB- by myricetin , dihydromyricetin , and myricitrin .
18802928	0	catechol_O-methyltransferase	20,48	COMT	50,54	catechol O-methyltransferase	COMT	1312	1312	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between catechol_O-methyltransferase -LRB- COMT -RRB- haplotypes and severity of hyperactivity symptoms in adults .
21531374	0	catechol_O-methyltransferase	77,105	COMT	107,111	catechol O-methyltransferase	COMT	1312	1312	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Severe early-onset preeclampsia is not associated with a change in placental catechol_O-methyltransferase -LRB- COMT -RRB- expression .
21106062	0	catenin	89,96	CTNND2	98,104	catenin	CTNND2	31151(Tax:7227)	1501	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human homolog of Drosophila Hairy_and_enhancer_of_split_1 , Hes1 , negatively regulates - catenin -LRB- CTNND2 -RRB- expression in cooperation with E2F1 in prostate_cancer .
17991725	0	catestatin	124,134	plasmin	145,152	catestatin	plasmin	1113	5340	Gene	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Proteolytic cleavage of human chromogranin_a containing naturally occurring catestatin variants : differential processing at catestatin region by plasmin .
9413220	0	cathepsin-D	22,33	pS2	35,38	cathepsin-D	pS2	1509	338412	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Relationships between cathepsin-D , pS2 protein and hormonal receptors in breast_cancer cytosols : inconsistency with their established prognostic significance .
25565868	0	cathepsin_B	59,70	APAF-1	24,30	cathepsin B	APAF-1	1508	317	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Decreased expression of APAF-1 and increased expression of cathepsin_B in invasive pituitary_adenoma .
1577456	0	cathepsin_B	26,37	CTSB	44,48	cathepsin B	CTSB	1508	1508	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Confirmation of the human cathepsin_B gene -LRB- CTSB -RRB- assignment to chromosome 8 .
26682926	0	cathepsin_B	56,67	Cathepsin_D	0,11	cathepsin B	Cathepsin D	13030(Tax:10090)	13033(Tax:10090)	Gene	Gene	implicated|nmod|START_ENTITY implicated|nsubjpass|END_ENTITY	Cathepsin_D in pancreatic acinar cells is implicated in cathepsin_B and L degradation , but not in autophagic activity .
16183211	0	cathepsin_B	51,62	Cathepsin_L	0,11	cathepsin B	Cathepsin L	1508	1514	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Cathepsin_L in glioma progression : comparison with cathepsin_B .
15769846	0	cathepsin_B	55,66	Caveolin-1	0,10	cathepsin B	Caveolin-1	1508	857	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Caveolin-1 mediates the expression and localization of cathepsin_B , pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal_carcinoma cells .
10065424	0	cathepsin_B	45,56	CtsB	63,67	cathepsin B	CtsB	64529(Tax:10116)	64529(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genome scanning detects amplification of the cathepsin_B gene -LRB- CtsB -RRB- in transformed rat ovarian surface epithelial cells .
19454696	0	cathepsin_B	19,30	Granulysin	0,10	cathepsin B	Granulysin	1508	10578	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Granulysin induces cathepsin_B release from lysosomes of target_tumor cells to attack mitochondria through processing of bid leading to Necroptosis .
23364980	0	cathepsin_B	30,41	Interleukin-10	0,14	cathepsin B	Interleukin-10	64529(Tax:10116)	25325(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Interleukin-10 down-regulates cathepsin_B expression in fetal rat alveolar type II cells exposed to hyperoxia .
20110692	0	cathepsin_B	52,63	Interleukin-6	0,13	cathepsin B	Interleukin-6	1508	3569	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-6 increases expression and secretion of cathepsin_B by breast_tumor-associated monocytes .
15736427	0	cathepsin_B	14,25	Sp1	0,3	cathepsin B	Sp1	13030(Tax:10090)	20683(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Sp1 regulates cathepsin_B transcription and invasiveness in murine B16 melanoma cells .
17064696	0	cathepsin_B	35,46	Sphingosine_kinase-1	0,20	cathepsin B	Sphingosine kinase-1	1508	8877	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Sphingosine_kinase-1 is cleaved by cathepsin_B in vitro : identification of the initial cleavage sites for the protease .
8872491	0	cathepsin_B	52,63	THP-1	87,92	cathepsin B	THP-1	1508	2736	Gene	Gene	activity|compound|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Gamma interferon induced increases in intracellular cathepsin_B activity in PMA primed THP-1 cells are blocked by inhibitors of protein_kinase_C .
9119982	0	cathepsin_B	52,63	THP-1	76,81	cathepsin B	THP-1	1508	2736	Gene	Gene	activity|compound|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Interferon-gamma induced increases in intracellular cathepsin_B activity in THP-1 cells are dependent on RNA transcription .
9130007	0	cathepsin_B	42,53	THP-1	66,71	cathepsin B	THP-1	1508	2736	Gene	Gene	activity|compound|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Endotoxin induces increased intracellular cathepsin_B activity in THP-1 cells .
9458327	0	cathepsin_B	57,68	THP-1	81,86	cathepsin B	THP-1	1508	2736	Gene	Gene	activity|amod|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Effect of protein kinase modulators on the regulation of cathepsin_B activity in THP-1 human monocytic_leukemia cells .
9828078	0	cathepsin_B	52,63	THP-1	67,72	cathepsin B	THP-1	1508	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Modulation of interferon gamma induced increases in cathepsin_B in THP-1 cells by adrenergic agonists and antagonists .
10809954	0	cathepsin_B	10,21	cathepsin_D	75,86	cathepsin B	cathepsin D	13030(Tax:10090)	13033(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY plays|advcl|involved involved|nsubjpass|END_ENTITY	Lysosomal cathepsin_B plays an important role in antigen processing , while cathepsin_D is involved in degradation of the invariant chain inovalbumin-immunized mice .
6231380	0	cathepsin_B	19,30	cathepsin_D	130,141	cathepsin B	cathepsin D	1508	1509	Gene	Gene	activity|compound|START_ENTITY Changes|nmod|activity Changes|dep|comparison comparison|nmod|END_ENTITY	Changes in cardiac cathepsin_B activity in response to interventions that alter heart size or protein metabolism : comparison with cathepsin_D .
10937745	0	cathepsin_B	137,148	cathepsin_L	71,82	cathepsin B	cathepsin L	1508	1514	Gene	Gene	profiles|nmod|START_ENTITY comparisons|nmod|profiles Development|dep|comparisons Development|nmod|peptidyl_alpha-keto-beta-aldehydes peptidyl_alpha-keto-beta-aldehydes|nmod|inhibitors inhibitors|nmod|END_ENTITY	Development of peptidyl_alpha-keto-beta-aldehydes as new inhibitors of cathepsin_L -- comparisons of potency and selectivity profiles with cathepsin_B .
16913838	0	cathepsin_B	65,76	cathepsin_L	6,17	cathepsin B	cathepsin L	13030(Tax:10090)	13039(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY neurodegeneration|nmod|mice rescues|dobj|neurodegeneration rescues|nsubj|END_ENTITY	Human cathepsin_L rescues the neurodegeneration and lethality in cathepsin_B / L double-deficient mice .
18616803	0	cathepsin_B	49,60	cathepsin_L	62,73	cathepsin B	cathepsin L	1508	1514	Gene	Gene	activator|compound|START_ENTITY activator|dep|END_ENTITY	Tumor marker utility and prognostic relevance of cathepsin_B , cathepsin_L , urokinase-type_plasminogen_activator , plasminogen activator inhibitor type-1 , CEA and CA 19-9 in colorectal_cancer .
2317204	0	cathepsin_B	85,96	cathepsin_L	65,76	cathepsin B	cathepsin L	1508	1514	Gene	Gene	extensively|nmod|START_ENTITY extensively|nmod|END_ENTITY	Cartilage proteoglycan aggregate is degraded more extensively by cathepsin_L than by cathepsin_B .
3688881	0	cathepsin_B	65,76	cathepsin_L	10,21	cathepsin B	cathepsin L	64529(Tax:10116)	25697(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|dep|characterization	Rat brain cathepsin_L : characterization and differentiation from cathepsin_B utilizing opioid peptides .
7612192	0	cathepsin_B	78,89	cathepsin_L	14,25	cathepsin B	cathepsin L	1508	1514	Gene	Gene	activity|amod|START_ENTITY Assessment|acl|activity Assessment|nmod|activity activity|amod|END_ENTITY	Assessment of cathepsin_L activity by use of the inhibitor CA-074 compared to cathepsin_B activity in human lung_tumor tissue .
25422248	0	cathepsin_B	6,17	cystatin_C	21,31	cathepsin B	cystatin C	1508	1471	Gene	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Serum cathepsin_B to cystatin_C ratio as a potential marker for the diagnosis of cholangiocarcinoma .
17663518	0	cathepsin_B	95,106	endothelin-1	10,22	cathepsin B	endothelin-1	1508	1906	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 in esophageal_squamous_cell_carcinoma invasion and its correlation with cathepsin_B .
14662875	0	cathepsin_B	61,72	epidermal_growth_factor_receptor	109,141	cathepsin B	epidermal growth factor receptor	13030(Tax:10090)	13649(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	IL-8-mediated cell migration in endothelial cells depends on cathepsin_B activity and transactivation of the epidermal_growth_factor_receptor .
2176623	0	cathepsin_B	50,61	interleukin-1_beta	10,28	cathepsin B	interleukin-1 beta	100101593(Tax:9986)	100008990(Tax:9986)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effect of interleukin-1_beta on the production of cathepsin_B by rabbit articular chondrocytes .
20166242	0	cathepsin_B	96,107	matrix_metalloproteinase_9	157,183	cathepsin B	matrix metalloproteinase 9	1508	4318	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin_B and nuclear_factor_kappa_B-mediated induction of matrix_metalloproteinase_9 .
23017058	0	cathepsin_B	79,90	tissue_inhibitor_of_metalloproteinase_1	106,145	cathepsin B	tissue inhibitor of metalloproteinase 1	13030(Tax:10090)	21857(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Activation of the P2X receptor induces migration of glial cells by inducing cathepsin_B degradation of tissue_inhibitor_of_metalloproteinase_1 .
18616803	0	cathepsin_B	49,60	urokinase-type_plasminogen_activator	75,111	cathepsin B	urokinase-type plasminogen activator	1508	5328	Gene	Gene	activator|compound|START_ENTITY activator|dep|END_ENTITY	Tumor marker utility and prognostic relevance of cathepsin_B , cathepsin_L , urokinase-type_plasminogen_activator , plasminogen activator inhibitor type-1 , CEA and CA 19-9 in colorectal_cancer .
18714186	0	cathepsin_B	6,17	urokinase-type_plasminogen_activator	29,65	cathepsin B	urokinase-type plasminogen activator	1508	5328	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Serum cathepsin_B and plasma urokinase-type_plasminogen_activator levels in gastrointestinal_tract_cancers .
15585850	0	cathepsin_C	94,105	dipeptidyl_peptidase_I	106,128	cathepsin C	dipeptidyl peptidase I	1075	1075	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Papillon-Lef __ vre_syndrome : correlating the molecular , cellular , and clinical consequences of cathepsin_C / dipeptidyl_peptidase_I deficiency in humans .
16386934	0	cathepsin_D	18,29	CTSD	36,40	cathepsin D	CTSD	483662(Tax:9615)	483662(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|appos|END_ENTITY	A mutation in the cathepsin_D gene -LRB- CTSD -RRB- in American Bulldogs with neuronal_ceroid_lipofuscinosis .
18607787	0	cathepsin_D	77,88	CTSD	90,94	cathepsin D	CTSD	494568(Tax:9823)	494568(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence identification , tissue distribution and polymorphism of the porcine cathepsin_D -LRB- CTSD -RRB- gene .
10690542	0	cathepsin_D	102,113	Cathepsin_B	0,11	cathepsin D	Cathepsin B	1509	1508	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Cathepsin_B , a prognostic indicator in lymph node-negative breast_carcinoma patients : comparison with cathepsin_D , cathepsin_L , and other clinical indicators .
17908479	0	cathepsin_D	40,51	E-cadherin	14,24	cathepsin D	E-cadherin	1509	999	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Expression of E-cadherin , beta-catenin , cathepsin_D , gelatinases and their inhibitors in invasive_ductal_breast_carcinomas .
9779488	0	cathepsin_D	59,70	PCNA	96,100	cathepsin D	PCNA	1509	5111	Gene	Gene	fraction|amod|START_ENTITY expression|nmod|fraction expression|appos|END_ENTITY	Correlated expression of BCL-2 protein , estrogen_receptor , cathepsin_D and low growth fraction -LRB- PCNA -RRB- in intracystic_papillary_breast_carcinoma .
18559512	0	cathepsin_D	22,33	Thrombin	0,8	cathepsin D	Thrombin	1509	2147	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Thrombin up-regulates cathepsin_D which enhances angiogenesis , growth , and metastasis .
10987196	0	cathepsin_D	24,35	beta2-microglobulin	58,77	cathepsin D	beta2-microglobulin	1509	567	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	Probable involvement of cathepsin_D in the degradation of beta2-microglobulin in acidic urine .
10809954	0	cathepsin_D	75,86	cathepsin_B	10,21	cathepsin D	cathepsin B	13033(Tax:10090)	13030(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY plays|advcl|involved plays|nsubj|END_ENTITY	Lysosomal cathepsin_B plays an important role in antigen processing , while cathepsin_D is involved in degradation of the invariant chain inovalbumin-immunized mice .
6231380	0	cathepsin_D	130,141	cathepsin_B	19,30	cathepsin D	cathepsin B	1509	1508	Gene	Gene	comparison|nmod|START_ENTITY Changes|dep|comparison Changes|nmod|activity activity|compound|END_ENTITY	Changes in cardiac cathepsin_B activity in response to interventions that alter heart size or protein metabolism : comparison with cathepsin_D .
15239346	0	cathepsin_D	55,66	matrix_metalloproteinase-2	27,53	cathepsin D	matrix metalloproteinase-2	1509	4313	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of matrix_metalloproteinase-2 , cathepsin_D , and tenascin-C expression in colorectal_carcinoma .
2421004	0	cathepsin_D	22,33	myelin_basic_protein	50,70	cathepsin D	myelin basic protein	1509	4155	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Acidic lipids enhance cathepsin_D cleavage of the myelin_basic_protein .
11240767	0	cathepsin_D	52,63	p53	31,34	cathepsin D	p53	1509	7157	Gene	Gene	START_ENTITY|nsubj|significance significance|nmod|END_ENTITY	The prognostic significance of p53 , mdm2 , c-erbB-2 , cathepsin_D , and thrombocytosis in stage_IB_cervical_cancer treated by primary radical hysterectomy .
8518412	0	cathepsin_D	20,31	p53	0,3	cathepsin D	p53	1509	7157	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	p53 associated with cathepsin_D in primary breast_cancer .
16196369	0	cathepsin_D	10,21	transforming_growth_factor-beta	62,93	cathepsin D	transforming growth factor-beta	1509	7040	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cathepsin_D and prostate_specific_antigen on latent transforming_growth_factor-beta in breast_cancer cell lines .
17888866	0	cathepsin_E	24,35	constitutive_androstane_receptor	48,80	cathepsin E	constitutive androstane receptor	1510	9970	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the human cathepsin_E gene by the constitutive_androstane_receptor .
16963053	0	cathepsin_F	53,64	Angiotensin_II	0,14	cathepsin F	Angiotensin II	8722	183	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases expression and secretion of cathepsin_F in cultured human monocyte-derived macrophages : an angiotensin_II_type_2_receptor-mediated effect .
17302735	0	cathepsin_G	27,38	Interferon-gamma	0,16	cathepsin G	Interferon-gamma	101098719	493965(Tax:9685)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Interferon-gamma regulates cathepsin_G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin_basic_protein in vitro .
8408036	0	cathepsin_G	72,83	Thrombospondin_1	0,16	cathepsin G	Thrombospondin 1	1511	7057	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Thrombospondin_1 is a tight-binding competitive inhibitor of neutrophil cathepsin_G .
1716791	0	cathepsin_G	63,74	alpha_2-macroglobulin	14,35	cathepsin G	alpha 2-macroglobulin	1511	2	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of alpha_2-macroglobulin on human polymorphonuclear cathepsin_G .
6696878	1	cathepsin_G	111,122	angiotensinogen	50,65	cathepsin G	angiotensinogen	1511	183	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of angiotensinogen as the plasma protein substrate of leukocyte cathepsin_G .
8400294	0	cathepsin_G	29,40	thrombin	123,131	cathepsin G	thrombin	1511	2147	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of leukocyte-derived cathepsin_G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes : a comparison with thrombin .
8850655	0	cathepsin_G_and_elastase	83,107	C-reactive_protein	63,81	cathepsin G and elastase	C-reactive protein	1511	1401	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|END_ENTITY	Salivary levels of alpha_2-macroglobulin , alpha 1-antitrypsin , C-reactive_protein , cathepsin_G_and_elastase in humans with or without destructive_periodontal_disease .
7722423	0	cathepsin_H	20,31	IFN-gamma	0,9	cathepsin H	IFN-gamma	13036(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	IFN-gamma increases cathepsin_H mRNA levels in mouse macrophages .
19662513	0	cathepsin_K	48,59	CTSK	61,65	cathepsin K	CTSK	397569(Tax:9823)	397569(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A single nucleotide polymorphism in the porcine cathepsin_K -LRB- CTSK -RRB- gene is associated with back fat thickness and production traits in Italian Duroc pigs .
20305575	0	cathepsin_K	29,40	CTSK	42,46	cathepsin K	CTSK	1513	1513	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel missense mutation in cathepsin_K -LRB- CTSK -RRB- gene in a consanguineous Pakistani family with pycnodysostosis .
21099701	0	cathepsin_K	79,90	CTSK	68,72	cathepsin K	CTSK	1513	1513	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Familial_pycnodysostosis : identification of a novel mutation in the CTSK gene -LRB- cathepsin_K -RRB- .
9143491	0	cathepsin_K	62,73	CTSK	80,84	cathepsin K	CTSK	1513	1513	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and chromosome localization of the human cathepsin_K gene -LRB- CTSK -RRB- .
15381721	0	cathepsin_K	21,32	IL-1alpha	0,9	cathepsin K	IL-1alpha	1513	3552	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	IL-1alpha stimulates cathepsin_K expression in osteoclasts via the tyrosine kinase-NF-kappaB pathway .
11269728	0	cathepsin_K	51,62	Interferon-gamma	0,16	cathepsin K	Interferon-gamma	13038(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interferon-gamma down-regulates gene expression of cathepsin_K in osteoclasts and inhibits osteoclast formation .
20937352	0	cathepsin_K	24,35	Interleukin-17A	0,15	cathepsin K	Interleukin-17A	13038(Tax:10090)	16171(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-17A induces cathepsin_K and MMP-9 expression in osteoclasts via celecoxib-blocked prostaglandin_E2 in osteoblasts .
20061146	0	cathepsin_K	49,60	MK-0674	17,24	cathepsin K	MK-0674	1513	1476775(Tax:190192)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	The discovery of MK-0674 , an orally bioavailable cathepsin_K inhibitor .
18811135	0	cathepsin_K	49,60	MK-1256	72,79	cathepsin K	MK-1256	1513	1477851(Tax:190192)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Identification of a nonbasic , nitrile-containing cathepsin_K inhibitor -LRB- MK-1256 -RRB- that is efficacious in a monkey model of osteoporosis .
16045809	0	cathepsin_K	18,29	TGF-beta	81,89	cathepsin K	TGF-beta	13038(Tax:10090)	21803(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of cathepsin_K during silica-induced lung_fibrosis and control by TGF-beta .
22562303	0	cathepsin_K	39,50	Tumor_necrosis_factor_alpha	0,27	cathepsin K	Tumor necrosis factor alpha	1513	7124	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha stimulates cathepsin_K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation .
27049030	0	cathepsin_K	6,17	type_II_collagen	33,49	cathepsin K	type II collagen	100054991(Tax:9796)	791241(Tax:9796)	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	Early cathepsin_K degradation of type_II_collagen in vitro and in vivo in articular cartilage .
21687683	0	cathepsin_L	56,67	C/EBPa	94,100	cathepsin L	C/EBPa	1514	1050	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Down regulation of a matrix degrading cysteine protease cathepsin_L , by acetaldehyde : role of C/EBPa .
22871890	0	cathepsin_L	67,78	CTSL1	80,85	cathepsin L	CTSL1	1514	1514	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Genes and environment : novel , functional polymorphism in the human cathepsin_L -LRB- CTSL1 -RRB- promoter disrupts a xenobiotic response element -LRB- XRE -RRB- to alter transcription and blood pressure .
11306582	0	cathepsin_L	40,51	Cathepsin_S	0,11	cathepsin L	Cathepsin S	13039(Tax:10090)	13040(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cathepsin_S regulates the expression of cathepsin_L and the turnover of gamma-interferon-inducible_lysosomal_thiol_reductase in B lymphocytes .
3438085	0	cathepsin_L	20,31	Cysteine_proteinase	0,19	cathepsin L	Cysteine proteinase	13039(Tax:10090)	12334(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Cysteine_proteinase cathepsin_L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts .
20088826	0	cathepsin_L	4,15	FOXO1	43,48	cathepsin L	FOXO1	13039(Tax:10090)	56458(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	The cathepsin_L gene is a direct target of FOXO1 in skeletal muscle .
12809493	0	cathepsin_L	45,56	Hurpin	0,6	cathepsin L	Hurpin	1514	5275	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Hurpin is a selective inhibitor of lysosomal cathepsin_L and protects keratinocytes from ultraviolet-induced apoptosis .
20230872	0	cathepsin_L	35,46	Protein_C_inhibitor	0,19	cathepsin L	Protein C inhibitor	1514	5104	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Protein_C_inhibitor regulates both cathepsin_L activity and cell-mediated tumor cell migration .
17574778	0	cathepsin_L	38,49	VEGF	53,57	cathepsin L	VEGF	1514	7422	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of human cathepsin_L by VEGF in glioblastoma cells .
10937745	0	cathepsin_L	71,82	cathepsin_B	137,148	cathepsin L	cathepsin B	1514	1508	Gene	Gene	inhibitors|nmod|START_ENTITY peptidyl_alpha-keto-beta-aldehydes|nmod|inhibitors Development|nmod|peptidyl_alpha-keto-beta-aldehydes Development|dep|comparisons comparisons|nmod|profiles profiles|nmod|END_ENTITY	Development of peptidyl_alpha-keto-beta-aldehydes as new inhibitors of cathepsin_L -- comparisons of potency and selectivity profiles with cathepsin_B .
16913838	0	cathepsin_L	6,17	cathepsin_B	65,76	cathepsin L	cathepsin B	13039(Tax:10090)	13030(Tax:10090)	Gene	Gene	rescues|nsubj|START_ENTITY rescues|dobj|neurodegeneration neurodegeneration|nmod|mice mice|amod|END_ENTITY	Human cathepsin_L rescues the neurodegeneration and lethality in cathepsin_B / L double-deficient mice .
18616803	0	cathepsin_L	62,73	cathepsin_B	49,60	cathepsin L	cathepsin B	1514	1508	Gene	Gene	activator|dep|START_ENTITY activator|compound|END_ENTITY	Tumor marker utility and prognostic relevance of cathepsin_B , cathepsin_L , urokinase-type_plasminogen_activator , plasminogen activator inhibitor type-1 , CEA and CA 19-9 in colorectal_cancer .
2317204	0	cathepsin_L	65,76	cathepsin_B	85,96	cathepsin L	cathepsin B	1514	1508	Gene	Gene	extensively|nmod|START_ENTITY extensively|nmod|END_ENTITY	Cartilage proteoglycan aggregate is degraded more extensively by cathepsin_L than by cathepsin_B .
3688881	0	cathepsin_L	10,21	cathepsin_B	65,76	cathepsin L	cathepsin B	25697(Tax:10116)	64529(Tax:10116)	Gene	Gene	START_ENTITY|dep|characterization characterization|nmod|END_ENTITY	Rat brain cathepsin_L : characterization and differentiation from cathepsin_B utilizing opioid peptides .
7612192	0	cathepsin_L	14,25	cathepsin_B	78,89	cathepsin L	cathepsin B	1514	1508	Gene	Gene	activity|amod|START_ENTITY Assessment|nmod|activity Assessment|acl|activity activity|amod|END_ENTITY	Assessment of cathepsin_L activity by use of the inhibitor CA-074 compared to cathepsin_B activity in human lung_tumor tissue .
2044774	0	cathepsin_L	88,99	cathepsin_S	43,54	cathepsin L	cathepsin S	515200(Tax:9913)	327711(Tax:9913)	Gene	Gene	sequence|nmod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of bovine cathepsin_S and a partial sequence of bovine cathepsin_L .
7982933	0	cathepsin_L	65,76	cathepsin_S	48,59	cathepsin L	cathepsin S	1514	1520	Gene	Gene	specificity|amod|START_ENTITY subsite|nmod|specificity subsite|dobj|specificity specificity|nmod|END_ENTITY	Engineering the S2 subsite specificity of human cathepsin_S to a cathepsin_L - and cathepsin_B-like specificity .
7116206	0	cathepsin_L	14,25	haptoglobin	35,46	cathepsin L	haptoglobin	25697(Tax:10116)	24464(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cathepsin_L and B by haptoglobin , the haptoglobin-hemoglobin complex , and asialohaptoglobin .
17869649	0	cathepsin_L2	21,33	CTSL2	35,40	cathepsin L2	CTSL2	1515	1515	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the cathepsin_L2 -LRB- CTSL2 -RRB- gene show association with type 1 diabetes and early-onset myasthenia_gravis .
9790772	0	cathepsin_O	60,71	CTSO	78,82	cathepsin O	CTSO	1519	1519	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosomal localization of the human cathepsin_O gene -LRB- CTSO -RRB- .
7805878	0	cathepsin_O	27,38	OC2	87,90	cathepsin O	OC2	1519	100009334(Tax:9986)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of human cathepsin_O , a novel endoproteinase and homologue of rabbit OC2 .
10721671	0	cathepsin_S	6,17	CTSS	24,28	cathepsin S	CTSS	1520	1520	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human cathepsin_S gene -LRB- CTSS -RRB- promoter -25 G/A polymorphism .
2044774	0	cathepsin_S	43,54	cathepsin_L	88,99	cathepsin S	cathepsin L	327711(Tax:9913)	515200(Tax:9913)	Gene	Gene	sequence|nmod|START_ENTITY sequence|nmod|END_ENTITY	The complete amino_acid sequence of bovine cathepsin_S and a partial sequence of bovine cathepsin_L .
7982933	0	cathepsin_S	48,59	cathepsin_L	65,76	cathepsin S	cathepsin L	1520	1514	Gene	Gene	specificity|nmod|START_ENTITY subsite|dobj|specificity subsite|nmod|specificity specificity|amod|END_ENTITY	Engineering the S2 subsite specificity of human cathepsin_S to a cathepsin_L - and cathepsin_B-like specificity .
16436681	0	cathepsin_S	35,46	cysteine_protease	16,33	cathepsin S	cysteine protease	1520	1508	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of cysteine_protease , cathepsin_S , to the surface of vascular smooth muscle cells by association with integrin alphanubeta3 .
8313966	0	cathepsin_S	33,44	stefin_B	55,63	cathepsin S	stefin B	327711(Tax:9913)	512805(Tax:9913)	Gene	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics of inhibition of bovine cathepsin_S by bovine stefin_B .
24121514	0	cathepsin_V	23,34	Elastin	0,7	cathepsin V	Elastin	1515	2006	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Elastin degradation by cathepsin_V requires two exosites .
9727401	0	cathepsin_V	40,51	proteinase	61,71	cathepsin V	proteinase	1515	100616101	Gene	Gene	Isolation|nmod|START_ENTITY Isolation|dep|END_ENTITY	Isolation and characterization of human cathepsin_V : a major proteinase in corneal epithelium .
12112662	0	cathepsin_c	43,54	CTSC	61,65	cathepsin c	CTSC	1075	1075	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Biochemical and mutational analyses of the cathepsin_c gene -LRB- CTSC -RRB- in three North American families with Papillon_Lef __ vre_syndrome .
11177576	0	cathepsins_B_and_L	74,92	Interleukin-6_and_transforming_growth_factor-beta_1	0,51	cathepsins B and L	Interleukin-6 and transforming growth factor-beta 1	1508;1514	3569;7040	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin-6_and_transforming_growth_factor-beta_1 control expression of cathepsins_B_and_L in human lung epithelial cells .
10594701	0	cation-independent_mannose_6-phosphate_receptor	18,65	insulin-like_growth_factor_type-2_receptor	66,108	cation-independent mannose 6-phosphate receptor	insulin-like growth factor type-2 receptor	3482	3482	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of cation-independent_mannose_6-phosphate_receptor / insulin-like_growth_factor_type-2_receptor as a novel target of autoantibodies .
9573062	0	cationic_antimicrobial_protein	44,74	CAP18	76,81	cationic antimicrobial protein	CAP18	820	820	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Protective effects of a human 18-kilodalton cationic_antimicrobial_protein -LRB- CAP18 -RRB- - derived peptide against murine endotoxemia .
9428573	0	cationic_leukocyte_antigen	41,67	CLA	69,72	cationic leukocyte antigen	CLA	6404	6404	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cellular and subcellular localization of cationic_leukocyte_antigen -LRB- CLA -RRB- in human eosinophil granulocytes .
11708864	0	cationic_trypsinogen	89,109	PRSS1	116,121	cationic trypsinogen	PRSS1	5644	5644	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a novel pancreatitis-associated missense mutation , R116C , in the human cationic_trypsinogen gene -LRB- PRSS1 -RRB- .
12765848	0	cationic_trypsinogen	36,56	PRSS1	63,68	cationic trypsinogen	PRSS1	5644	5644	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	`` Loss of function '' mutations in the cationic_trypsinogen gene -LRB- PRSS1 -RRB- may act as a protective factor against pancreatitis .
12939655	0	cationic_trypsinogen	94,114	PRSS1	116,121	cationic trypsinogen	PRSS1	5644	5644	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene , the cationic_trypsinogen -LRB- PRSS1 -RRB- gene , and the serine_protease_inhibitor , _ Kazal_type_1 -LRB- SPINK1 -RRB- gene in patients with alcoholic_chronic_pancreatitis .
19454815	0	cationic_trypsinogen	104,124	PRSS1	131,136	cationic trypsinogen	PRSS1	5644	5644	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hereditary_pancreatitis : clinical features and inheritance characteristics of the R122C mutation in the cationic_trypsinogen gene -LRB- PRSS1 -RRB- in six Spanish families .
6840407	0	cationic_trypsinogen	41,61	bombesin	23,31	cationic trypsinogen	bombesin	5644	2922	Gene	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	Dose-related effect of bombesin on serum cationic_trypsinogen levels .
25138215	0	caudal-related_Homeobox_2	97,122	FXR	85,88	caudal-related Homeobox 2	FXR	12591(Tax:10090)	20186(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Transcriptional Regulation of the Intestinal Nuclear Bile_Acid Farnesoid_X_Receptor -LRB- FXR -RRB- by the caudal-related_Homeobox_2 -LRB- CDX2 -RRB- .
25138215	0	caudal-related_Homeobox_2	97,122	Farnesoid_X_Receptor	63,83	caudal-related Homeobox 2	Farnesoid X Receptor	12591(Tax:10090)	20186(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Transcriptional Regulation of the Intestinal Nuclear Bile_Acid Farnesoid_X_Receptor -LRB- FXR -RRB- by the caudal-related_Homeobox_2 -LRB- CDX2 -RRB- .
11294831	0	caveolin-1	84,94	BENE	0,4	caveolin-1	BENE	857	7851	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BENE , a novel raft-associated protein of the MAL proteolipid family , interacts with caveolin-1 in human endothelial-like ECV304 cells .
18343216	0	caveolin-1	16,26	BRCA1	0,5	caveolin-1	BRCA1	857	672	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	BRCA1 regulates caveolin-1 expression and inhibits cell invasiveness .
16107720	0	caveolin-1	53,63	CD26	0,4	caveolin-1	CD26	857	1803	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells .
18789131	0	caveolin-1	18,28	EGFR	40,44	caveolin-1	EGFR	857	1956	Gene	Gene	internalization|amod|START_ENTITY internalization|compound|END_ENTITY	Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK .
19446582	0	caveolin-1	52,62	EGFR	87,91	caveolin-1	EGFR	857	1956	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Growth suppression by ursodeoxycholic_acid involves caveolin-1 enhanced degradation of EGFR .
17609206	0	caveolin-1	51,61	EMP2	22,26	caveolin-1	EMP2	857	2013	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The tetraspan protein EMP2 regulates expression of caveolin-1 .
19195865	0	caveolin-1	36,46	ERK1/2	62,68	caveolin-1	ERK1/2	857	5595;5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Green tea polyphenols down-regulate caveolin-1 expression via ERK1/2 and p38MAPK in endothelial cells .
19477952	0	caveolin-1	118,128	ERK2/1	32,38	caveolin-1	ERK2/1	857	5594;5595	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Compartmentalizing VEGF-induced ERK2/1 signaling in placental artery endothelial cell caveolae : a paradoxical role of caveolin-1 in placental angiogenesis in vitro .
19121286	0	caveolin-1	23,33	Flotillin-1	0,11	caveolin-1	Flotillin-1	857	10211	Gene	Gene	stabilizes|xcomp|START_ENTITY stabilizes|nsubj|END_ENTITY	Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells .
18923542	0	caveolin-1	58,68	HERG	49,53	caveolin-1	HERG	857	3757	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	The regulation of the cardiac potassium channel -LRB- HERG -RRB- by caveolin-1 .
21721581	0	caveolin-1	116,126	HO-1	142,146	caveolin-1	HO-1	857	3162	Gene	Gene	START_ENTITY|nmod|binding binding|nmod|END_ENTITY	Caveolin-1 is a competitive inhibitor of heme_oxygenase-1 -LRB- HO-1 -RRB- with heme : identification of a minimum sequence in caveolin-1 for binding to HO-1 .
21074769	0	caveolin-1	19,29	Leptin	0,6	caveolin-1	Leptin	857	3952	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Leptin upregulates caveolin-1 expression : implications for development of atherosclerosis .
16501093	0	caveolin-1	87,97	NSP4	26,30	caveolin-1	NSP4	857	400668	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1 .
17379346	0	caveolin-1	70,80	NSP4	10,14	caveolin-1	NSP4	857	400668	Gene	Gene	-|nmod|START_ENTITY interacts|nmod|- interacts|nsubj|END_ENTITY	Rotavirus NSP4 interacts with both the amino - and carboxyl-termini of caveolin-1 .
24220211	0	caveolin-1	75,85	NSP4	37,41	caveolin-1	NSP4	857	400668	Gene	Gene	binds|nmod|START_ENTITY domain|acl:relcl|binds END_ENTITY|dobj|domain	Mutational analysis of the rotavirus NSP4 enterotoxic domain that binds to caveolin-1 .
16405917	0	caveolin-1	23,33	Neurofibromin	0,13	caveolin-1	Neurofibromin	857	4763	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Neurofibromin binds to caveolin-1 and regulates ras , FAK , and Akt .
20395445	0	caveolin-1	11,21	PTEN	36,40	caveolin-1	PTEN	857	5728	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Pathologic caveolin-1 regulation of PTEN in idiopathic_pulmonary_fibrosis .
12813462	0	caveolin-1	61,71	Peroxisome_proliferator-activated_receptor-gamma	0,48	caveolin-1	Peroxisome proliferator-activated receptor-gamma	857	5468	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells .
24161393	0	caveolin-1	50,60	Pigment_epithelium-derived_factor	0,33	caveolin-1	Pigment epithelium-derived factor	857	57104	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells .
26842651	0	caveolin-1	8,18	Rac1	35,39	caveolin-1	Rac1	857	5879	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	A novel caveolin-1 / p85a/Rab5/Tiam1 / Rac1 signaling axis in tumor cell migration and invasion .
16480767	0	caveolin-1	96,106	Rock-1	72,78	caveolin-1	Rock-1	857	6093	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	Caveolin-1 and lipid rafts in confluent BeWo trophoblasts : evidence for Rock-1 association with caveolin-1 .
24632723	0	caveolin-1	15,25	SHP-2	0,5	caveolin-1	SHP-2	857	5781	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	SHP-2 binds to caveolin-1 and regulates Src activity via competitive inhibition of CSK in response to H2O2 in astrocytes .
25672415	0	caveolin-1	36,46	SHP-2	93,98	caveolin-1	SHP-2	857	5781	Gene	Gene	interaction|nmod|START_ENTITY dependent|nsubj|interaction dependent|nmod|domain domain|nmod|END_ENTITY	Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2 .
12235142	0	caveolin-1	27,37	STAT3	16,21	caveolin-1	STAT3	857	6774	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of STAT3 with caveolin-1 and heat_shock_protein_90 in plasma membrane raft and cytosolic complexes .
15314095	0	caveolin-1	26,36	THP-1	51,56	caveolin-1	THP-1	857	2736	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism .
20720263	0	caveolin-1	14,24	VEGF	59,63	caveolin-1	VEGF	857	7422	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of caveolin-1 expression and phosphorylation by VEGF in ovine amnion cells .
23426970	0	caveolin-1	22,32	VEGF	105,109	caveolin-1	VEGF	857	7422	Gene	Gene	induces|xcomp|START_ENTITY induces|nmod|END_ENTITY	Dexamethasone induces caveolin-1 in vascular endothelial cells : implications for attenuated responses to VEGF .
22370641	0	caveolin-1	31,41	WNT6	0,4	caveolin-1	WNT6	857	7475	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric_cancer cells .
17942630	0	caveolin-1	10,20	angiotensin_II	103,117	caveolin-1	angiotensin II	857	183	Gene	Gene	peptide|amod|START_ENTITY Effect|nmod|peptide evoked|nsubj|Effect evoked|nmod|END_ENTITY	Effect of caveolin-1 scaffolding peptide and 17beta-estradiol on intracellular Ca2 + kinetics evoked by angiotensin_II in human vascular smooth muscle cells .
21659644	0	caveolin-1	9,19	angiotensin_II	116,130	caveolin-1	angiotensin II	857	183	Gene	Gene	downregulation|amod|START_ENTITY prevents|nsubj|downregulation prevents|dobj|endothelial_nitric_oxide_synthase endothelial_nitric_oxide_synthase|dep|uncoupling uncoupling|nmod|END_ENTITY	Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial_nitric_oxide_synthase uncoupling by angiotensin_II in endothelial cells .
24049538	0	caveolin-1	55,65	angiotensin_II	13,27	caveolin-1	angiotensin II	857	183	Gene	Gene	expression|amod|START_ENTITY blocker|nmod|expression blocker|compound|END_ENTITY	Effect of an angiotensin_II type 1 receptor blocker on caveolin-1 expression in prostate_cancer cells .
16807357	0	caveolin-1	83,93	endothelial_nitric-oxide_synthase	17,50	caveolin-1	endothelial nitric-oxide synthase	857	4846	Gene	Gene	involves|nmod|START_ENTITY involves|nsubj|Translocation Translocation|nmod|END_ENTITY	Translocation of endothelial_nitric-oxide_synthase involves a ternary complex with caveolin-1 and NOSTRIN .
9712842	0	caveolin-1	20,30	endothelial_nitric-oxide_synthase	59,92	caveolin-1	endothelial nitric-oxide synthase	857	4846	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between caveolin-1 and the reductase domain of endothelial_nitric-oxide_synthase .
12787066	0	caveolin-1	43,53	extracellular_signal-regulated_kinase	73,110	caveolin-1	extracellular signal-regulated kinase	857	5594	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular_signal-regulated_kinase activity in B103 neuroblastoma cells : role in the pathogenesis of Parkinson 's _ disease .
12036959	0	caveolin-1	63,73	insulin_receptor	4,20	caveolin-1	insulin receptor	857	3643	Gene	Gene	phosphorylation|nmod|START_ENTITY catalyzes|dobj|phosphorylation catalyzes|nsubj|END_ENTITY	The insulin_receptor catalyzes the tyrosine phosphorylation of caveolin-1 .
11896597	0	caveolin-1	47,57	oxytocin_receptor	26,43	caveolin-1	oxytocin receptor	857	5021	Gene	Gene	domains|amod|START_ENTITY END_ENTITY|nmod|domains	Localization of the human oxytocin_receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response .
12185081	0	caveolin-1	14,24	protein_kinase_cepsilon	55,78	caveolin-1	protein kinase cepsilon	857	5581	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of caveolin-1 expression and secretion by a protein_kinase_cepsilon signaling pathway in human prostate_cancer cells .
20455999	0	caveolin-2	137,147	ERK	93,96	caveolin-2	ERK	858	5594	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activation activation|amod|END_ENTITY	A novel domain of caveolin-2 that controls nuclear targeting : regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2 .
12649076	0	caveolin-2	48,58	caveolin-3	92,102	caveolin-2	caveolin-1	858	857	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Caveolae-associated proteins in cardiomyocytes : caveolin-2 expression and interactions with caveolin-3 .
22879586	0	caveolin-3	92,102	Nedd4-2	136,143	caveolin-3	Nedd4-2	859	23327	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Cell surface expression of human ether-a-go-go-related gene -LRB- hERG -RRB- channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2 .
18544631	0	caveolin-3	15,25	TRPC1	0,5	caveolin-3	TRPC1	12391(Tax:10090)	22063(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne_muscular_dystrophy .
12649076	0	caveolin-3	92,102	caveolin-2	48,58	caveolin-1	caveolin-2	857	858	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Caveolae-associated proteins in cardiomyocytes : caveolin-2 expression and interactions with caveolin-3 .
9353265	0	caveolin-3	51,61	neuronal_nitric-oxide_synthase	15,45	caveolin-3	neuronal nitric-oxide synthase	29161(Tax:10116)	24598(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of neuronal_nitric-oxide_synthase with caveolin-3 in skeletal muscle .
9252390	0	caveolin-3	42,52	phosphofructokinase-M	15,36	caveolin-3	phosphofructokinase-M	12391(Tax:10090)	18642(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of phosphofructokinase-M with caveolin-3 in differentiated_skeletal_myotubes .
20304057	0	caveolin-3	44,54	vitamin_D_receptor	20,38	caveolin-3	vitamin D receptor	29161(Tax:10116)	24873(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between vitamin_D_receptor with caveolin-3 and regulation by 1,25-dihydroxyvitamin _ D3 in adult rat cardiomyocytes .
12135605	0	caveolin_1	14,24	IGF-I	0,5	caveolin 1	IGF-I	857	3479	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IGF-I induces caveolin_1 tyrosine phosphorylation and translocation in the lipid rafts .
25618412	0	caveolin_1	24,34	PTRF	0,4	caveolin 1	PTRF	857	284119	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	PTRF is associated with caveolin_1 at the time of receptivity : but SDPR is absent at the same time .
25164083	0	caveolin_1	8,18	angiotensin_II	55,69	caveolin 1	angiotensin II	857	183	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of caveolin_1 in AT1a receptor-mediated uptake of angiotensin_II in the proximal tubule of the kidney .
25588833	0	cavin1	22,28	Cavin3	0,6	cavin1	Cavin3	284119	112464	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae .
10086340	0	cbl-b	0,5	epidermal_growth_factor_receptor	15,47	cbl-b	epidermal growth factor receptor	868	1956	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	cbl-b inhibits epidermal_growth_factor_receptor signaling .
22614280	0	cbr1	51,55	carbonyl_reductase_1	29,49	cbr1	carbonyl reductase 1	610164(Tax:9615)	610164(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA sequence variants in the carbonyl_reductase_1 -LRB- cbr1 -RRB- gene in seven breeds of Canis_lupus_familiaris .
21118521	0	ccp1	73,77	FGF2	81,85	ccp1	FGF2	84317	2247	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1 , a FGF2 downstream gene .
24162716	0	ccr5	65,69	CD4	89,92	ccr5	CD4	1234	920	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|cells cells|nummod|END_ENTITY	Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4 + T cells from HIV-1_infection .
11067872	0	cd26	122,126	adenosine_deaminase	26,45	cd26	adenosine deaminase	1803	100	Gene	Gene	binding|nmod|START_ENTITY impairs|xcomp|binding site|parataxis|impairs site|nmod|END_ENTITY	The binding site of human adenosine_deaminase for CD26/Dipeptidyl _ peptidase_IV : the Arg142Gln mutation impairs binding to cd26 but does not cause immune_deficiency .
18341691	0	cd38	18,22	TNF-alpha	71,80	cd38	TNF-alpha	952	7124	Gene	Gene	promoter|amod|START_ENTITY Regulation|nmod|promoter smooth|nsubj|Regulation smooth|nmod|END_ENTITY	Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone .
17923692	0	cd44	31,35	c-Met	22,27	cd44	c-Met	12505(Tax:10090)	17295(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Haploinsufficiency of c-Met in cd44 - / - mice identifies a collaboration of CD44 and c-Met in vivo .
12839939	0	cd44	52,56	fra-1	43,48	cd44	fra-1	25406(Tax:10116)	25445(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma .
12881709	0	cdc2	54,58	Disabled-2	40,50	cdc2	Disabled-2	983	1601	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell cycle-dependent phosphorylation of Disabled-2 by cdc2 .
16465393	0	cdc2	14,18	KIP1	27,31	cdc2	KIP1	983	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cdc2 and p27 -LRB- KIP1 -RRB- phosphorylation in mitotic cells of the human retinoblastoma .
7541376	0	cdc2	44,48	MPF	57,60	cdc2	MPF	379785(Tax:8355)	379785(Tax:8355)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Brefeldin_A provokes indirect activation of cdc2 kinase -LRB- MPF -RRB- in Xenopus oocytes , resulting in meiotic cell division .
8420994	0	cdc2	21,25	Myb	41,44	cdc2	Myb	983	4602	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	c-myb transactivates cdc2 expression via Myb binding sites in the 5 ' - flanking region of the human cdc2 gene .
16407259	0	cdc2	74,78	RUNX2	44,49	cdc2	RUNX2	983	860	Gene	Gene	factor|nmod|START_ENTITY factor|compound|END_ENTITY	Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation .
12648761	0	cdc2	72,76	cell_division_cycle_2	49,70	cdc2	cell division cycle 2	983	983	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Increased frequency of a new polymorphism in the cell_division_cycle_2 -LRB- cdc2 -RRB- gene in patients with Alzheimer 's _ disease and frontotemporal_dementia .
8439342	0	cdc2	0,4	desmin	31,37	cdc2	desmin	983	1674	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	cdc2 kinase phosphorylation of desmin at three serine/threonine residues in the amino-terminal head domain .
11420663	0	cdc2	62,66	p34	58,61	cdc2	p34	983	79719	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|p55Cdc p55Cdc|nmod|END_ENTITY	Transcriptional upregulation and activation of p55Cdc via p34 -LRB- cdc2 -RRB- in Taxol-induced apoptosis .
11466212	0	cdc2	115,119	p34	111,114	cdc2	p34	983	55379	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Inhibition of phosphatidylinositol 3-kinase or mitogen-activated protein kinase kinase leads to suppression of p34 -LRB- cdc2 -RRB- kinase activity and meiotic progression beyond the meiosis I stage in porcine oocytes surrounded with cumulus cells .
11790456	0	cdc2	32,36	p34	28,31	cdc2	p34	12534(Tax:10090)	66939(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of instability of p34 -LRB- cdc2 -RRB- expression by treatment with cisplatin -LRB- CDDP -RRB- in mouse teratocarcinoma F9 cells .
12150824	0	cdc2	6,10	p34	2,5	cdc2	p34	12534(Tax:10090)	66939(Tax:10090)	Gene	Gene	survival|compound|START_ENTITY survival|amod|END_ENTITY	A p34 -LRB- cdc2 -RRB- survival checkpoint in cancer .
15539246	0	cdc2	105,109	p34	101,104	cdc2	p34	983	2967	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	R - -LRB- + -RRB- - perillyl_alcohol-induced cell cycle changes , altered actin cytoskeleton , and decreased ras and p34 -LRB- cdc2 -RRB- expression in colonic_adenocarcinoma SW480 cells .
16727806	0	cdc2	18,22	p34	14,17	cdc2	p34	281061(Tax:9913)	2967	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Activation of p34 -LRB- cdc2 -RRB- kinase around the meiotic resumption in bovine oocytes cultured in vitro .
18181150	0	cdc2	143,147	p34	139,142	cdc2	p34	54237(Tax:10116)	171435(Tax:10116)	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	The anti-apoptosis protein , survivin , mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34 -LRB- cdc2 -RRB- cyclin-dependent kinase .
8910383	0	cdc2	36,40	p34	32,35	cdc2	p34	983	902	Gene	Gene	dephosphorylation|appos|START_ENTITY dephosphorylation|nmod|END_ENTITY	Sequential dephosphorylation of p34 -LRB- cdc2 -RRB- on Thr-14 and Tyr-15 at the prophase/metaphase transition .
10514438	0	cdc2	25,29	p53	0,3	cdc2	p53	983	7157	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor .
11032828	0	cdc2	37,41	p53	66,69	cdc2	p53	983	7157	Gene	Gene	promoter|amod|START_ENTITY represses|dobj|promoter represses|nmod|END_ENTITY	p130/E2F4 binds to and represses the cdc2 promoter in response to p53 .
11327730	0	cdc2	85,89	p53	74,77	cdc2	p53	983	7157	Gene	Gene	p34|appos|START_ENTITY kinase|nmod|p34 kinase|nmod|binding binding|nmod|END_ENTITY	Downregulation of the cdc2/cyclin B protein kinase activity by binding of p53 to p34 -LRB- cdc2 -RRB- .
11420663	0	cdc2	62,66	p55Cdc	47,53	cdc2	p55Cdc	983	991	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation and activation of p55Cdc via p34 -LRB- cdc2 -RRB- in Taxol-induced apoptosis .
7983050	0	cdc2	58,62	vimentin	30,38	cdc2	vimentin	983	7431	Gene	Gene	kinase|amod|START_ENTITY phosphorylation|nmod|kinase phosphorylation|nsubj|Visualization Visualization|nmod|END_ENTITY	Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis .
8373419	0	cdc2	50,54	vimentin	29,37	cdc2	vimentin	983	7431	Gene	Gene	kinase|amod|START_ENTITY peptides|nmod|kinase peptides|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of synthetic vimentin peptides by cdc2 kinase .
17372985	0	cdc20	23,28	p55cdc	30,36	cdc20	p55cdc	107995(Tax:10090)	107995(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of neuronal cdc20 -LRB- p55cdc -RRB- expression by the plasticity-related transcription factor zif268 .
17372985	0	cdc20	23,28	zif268	96,102	cdc20	zif268	107995(Tax:10090)	13653(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY expression|nsubj|Regulation expression|nmod|END_ENTITY	Regulation of neuronal cdc20 -LRB- p55cdc -RRB- expression by the plasticity-related transcription factor zif268 .
9858615	0	cdc25A	82,88	transforming_growth_factor_beta	36,67	cdc25A	transforming growth factor beta	993	7040	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	E2F and histone deacetylase mediate transforming_growth_factor_beta repression of cdc25A during keratinocyte cell cycle arrest .
11396965	0	cdc25C	41,47	p53	98,101	cdc25C	p53	995	7157	Gene	Gene	down-regulated|nsubjpass|START_ENTITY down-regulated|nmod|END_ENTITY	Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73 .
10022854	0	cdc37	4,9	Raf-1	56,61	cdc37	Raf-1	12539(Tax:10090)	110157(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|compound|END_ENTITY	p50 -LRB- cdc37 -RRB- acting in concert with Hsp90 is required for Raf-1 function .
12504591	0	cdc42	87,92	IRSp53	31,37	cdc42	IRSp53	998	10458	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42 .
24276241	0	cdc42	29,34	cIAP1	0,5	cdc42	cIAP1	998	329	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation .
9082982	0	cdc42p	30,36	Bni1p	0,5	cdc42p	Bni1p	850930(Tax:4932)	855450(Tax:4932)	Gene	Gene	linking|dobj|START_ENTITY formin|xcomp|linking formin|advmod|END_ENTITY	Bni1p , a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis .
1382975	0	cdc48	30,35	VCP	0,3	cdc48	VCP	851431(Tax:4932)	7415	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	VCP , the mammalian homolog of cdc48 , is tyrosine phosphorylated in response to T_cell_antigen_receptor activation .
9422379	0	cdk-5	25,30	cdk-5	54,59	cdk-5	cdk-5	1020	1020	Gene	Gene	activity|amod|START_ENTITY activity|amod|/ /|amod|END_ENTITY	Cyclin_D2 interacts with cdk-5 and modulates cellular cdk-5 / p35 activity .
9422379	0	cdk-5	54,59	cdk-5	25,30	cdk-5	cdk-5	1020	1020	Gene	Gene	/|amod|START_ENTITY activity|amod|/ activity|amod|END_ENTITY	Cyclin_D2 interacts with cdk-5 and modulates cellular cdk-5 / p35 activity .
9422379	0	cdk-5	25,30	p35	60,63	cdk-5	p35	1020	8851	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Cyclin_D2 interacts with cdk-5 and modulates cellular cdk-5 / p35 activity .
9422379	0	cdk-5	54,59	p35	60,63	cdk-5	p35	1020	8851	Gene	Gene	/|amod|START_ENTITY activity|amod|/ activity|amod|END_ENTITY	Cyclin_D2 interacts with cdk-5 and modulates cellular cdk-5 / p35 activity .
18056467	0	cdk1	15,19	Cks1	0,4	cdk1	Cks1	983	137529	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cks1 regulates cdk1 expression : a novel role during mitotic entry in breast_cancer cells .
18372919	0	cdk2	9,13	Cyclin_A	0,8	cdk2	Cyclin A	1017	890	Gene	Gene	coordinates|nsubj|START_ENTITY END_ENTITY|parataxis|coordinates	Cyclin_A / cdk2 coordinates centrosomal and nuclear mitotic events .
19703905	0	cdk2	9,13	Cyclin_A	0,8	cdk2	Cyclin A	1017	890	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Cyclin_A / cdk2 regulates adenomatous_polyposis_coli-dependent mitotic spindle anchoring .
19773423	0	cdk2	48,52	PCAF	33,37	cdk2	PCAF	1017	8850	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The transcriptional co-activator PCAF regulates cdk2 activity .
1653904	0	cdk2	23,27	cyclin_A	50,58	cdk2	cyclin A	1017	890	Gene	Gene	gene|amod|START_ENTITY gene|acl:relcl|encodes encodes|dobj|p33 p33|amod|END_ENTITY	Isolation of the human cdk2 gene that encodes the cyclin_A - and adenovirus E1A-associated p33 kinase .
7799940	0	cdk2	91,95	cyclin_A	82,90	cdk2	cyclin A	1017	890	Gene	Gene	START_ENTITY|amod|binding binding|nmod|/ /|compound|END_ENTITY	The Rb-related p107 protein can suppress E2F function independently of binding to cyclin_A / cdk2 .
8622674	0	cdk2	37,41	p21	0,3	cdk2	p21	12566(Tax:10090)	12575(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY Disrupts|dobj|interaction Disrupts|nsubj|END_ENTITY	p21 Disrupts the interaction between cdk2 and the E2F-p130 complex .
8668341	0	cdk2	95,99	p21	0,3	cdk2	p21	1017	1026	Gene	Gene	activity|amod|START_ENTITY inhibit|dobj|activity required|xcomp|inhibit contains|parataxis|required contains|nsubj|END_ENTITY	p21 contains independent binding sites for cyclin and cdk2 : both sites are required to inhibit cdk2 kinase activity .
9626358	0	cdk2	90,94	p21	19,22	cdk2	p21	1017	1026	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|level level|nmod|END_ENTITY	Increased level of p21 in human ovarian_tumors is associated with increased expression of cdk2 , cyclin_A and PCNA .
9488039	0	cdk2	18,22	p27Kip1	44,51	cdk2	p27Kip1	1017	1027	Gene	Gene	sites|amod|START_ENTITY sites|nmod|inhibitor inhibitor|amod|END_ENTITY	Identification of cdk2 binding sites on the p27Kip1 cyclin-dependent kinase inhibitor .
17631145	0	cdk2	18,22	p27kip1	0,7	cdk2	p27kip1	12566(Tax:10090)	12576(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium : potential role in neoplasia .
15084261	0	cdk3	9,13	Cyclin_C	0,8	cdk3	Cyclin C	1018	892	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Cyclin_C / cdk3 promotes Rb-dependent G0 exit .
11955625	0	cdk3	54,58	ik3-2	0,5	cdk3	ik3-2	1018	81928	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	ik3-2 , a relative to ik3-1 / cables , is associated with cdk3 , cdk5 , and c-abl .
17894419	0	cdk4	10,14	Cyclin_D1	0,9	cdk4	Cyclin D1	1019	595	Gene	Gene	interact|nsubj|START_ENTITY END_ENTITY|parataxis|interact	Cyclin_D1 / cdk4 can interact with E2F4/DP1 and disrupts its DNA-binding capacity .
7739541	0	cdk4	96,100	Cyclin_D1	0,9	cdk4	Cyclin D1	1019	595	Gene	Gene	activity|amod|START_ENTITY dispensable|nmod|activity dispensable|nsubj|END_ENTITY	Cyclin_D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity .
9271411	0	cdk4	83,87	Cyclin_D1	0,9	cdk4	Cyclin D1	1019	595	Gene	Gene	activity|nmod|START_ENTITY transcriptional|dobj|activity transcriptional|nsubj|stimulation stimulation|amod|END_ENTITY	Cyclin_D1 stimulation of estrogen_receptor transcriptional activity independent of cdk4 .
10329038	0	cdk4	80,84	MDM2	64,68	cdk4	MDM2	1019	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10329038	0	cdk4	80,84	TP53	58,62	cdk4	TP53	1019	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10329038	0	cdk4	80,84	cyclin_D1	86,95	cdk4	cyclin D1	1019	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
16024155	0	cdk4	126,130	cyclin_D1	116,125	cdk4	cyclin D1	94201(Tax:10116)	58919(Tax:10116)	Gene	Gene	Induction|parataxis|START_ENTITY Induction|nmod|progression progression|nmod|activation activation|nmod|END_ENTITY	Induction of urothelial proliferation in rats by aristolochic_acid through cell cycle progression via activation of cyclin_D1 / cdk4 and cyclin_E / cdk2 .
19143767	0	cdk4	38,42	cyclin_D1	28,37	cdk4	cyclin D1	1019	595	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Myc down-regulation affects cyclin_D1 / cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line .
9290582	0	cdk4	30,34	cyclin_D1	20,29	cdk4	cyclin D1	94201(Tax:10116)	58919(Tax:10116)	Gene	Gene	Immunoreactivity|parataxis|START_ENTITY Immunoreactivity|nmod|END_ENTITY	Immunoreactivity of cyclin_D1 / cdk4 in neurons and oligodendrocytes after focal cerebral_ischemia in rat .
16601140	0	cdk4	26,30	cyclin_d1	16,25	cdk4	cyclin d1	1019	595	Gene	Gene	subtype|nsubj|START_ENTITY Role|parataxis|subtype Role|nmod|END_ENTITY	Role of complex cyclin_d1 / cdk4 in somatostatin subtype 2 receptor-mediated inhibition of cell proliferation of a medullary_thyroid_carcinoma cell line in vitro .
12126957	0	cdk4	55,59	p16	19,22	cdk4	p16	1019	1029	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	Hypoxia stimulates p16 expression and association with cdk4 .
10329038	0	cdk4	80,84	p21	70,73	cdk4	p21	1019	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10329038	0	cdk4	80,84	p27	75,78	cdk4	p27	1019	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
11046139	0	cdk4	55,59	p53	0,3	cdk4	p53	1019	7157	Gene	Gene	region|nmod|START_ENTITY binds|nmod|region binds|nsubj|END_ENTITY	p53 binds selectively to the 5 ' untranslated region of cdk4 , an RNA element necessary and sufficient for transforming_growth_factor_beta - and p53-mediated translational inhibition of cdk4 .
11046139	0	cdk4	183,187	transforming_growth_factor_beta	105,136	cdk4	transforming growth factor beta	1019	7040	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	p53 binds selectively to the 5 ' untranslated region of cdk4 , an RNA element necessary and sufficient for transforming_growth_factor_beta - and p53-mediated translational inhibition of cdk4 .
19158430	0	cdk5	23,27	Abeta	67,72	cdk5	Abeta	1020	351	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Abeta -LRB- 25-35 -RRB- : involvement of lipid rafts .
11813240	0	cdk5	27,31	Cyclin-dependent_kinase_5	0,25	cdk5	Cyclin-dependent kinase 5	1020	1020	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activation requires interaction with three domains of p35 .
14627648	0	cdk5	37,41	cyclin-dependent_kinase_5	10,35	cdk5	cyclin-dependent kinase 5	12568(Tax:10090)	12568(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Decreased cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice .
22889803	0	cdk5	130,134	cyclin-dependent_kinase_5	103,128	cdk5	cyclin-dependent kinase 5	1020	1020	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Synthesis and structure-activity relationship of 4 - -LRB- 1,3-benzothiazol-2-yl -RRB- - thiophene-2-sulfonamides as cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- / p25 inhibitors .
9313898	0	cdk5	116,120	hNF-H	70,75	cdk5	hNF-H	1020	4744	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of human high molecular weight neurofilament protein -LRB- hNF-H -RRB- by neuronal cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- .
10706614	0	cdk5	121,125	p25	100,103	cdk5	p25	1020	8851	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25 , an activator of cdk5 .
10903889	0	cdk5	14,18	p25	56,59	cdk5	p25	140908(Tax:10116)	170496(Tax:10116)	Gene	Gene	activator|amod|START_ENTITY Processing|nmod|activator p35|nsubj|Processing p35|nmod|form form|appos|END_ENTITY	Processing of cdk5 activator p35 to its truncated form -LRB- p25 -RRB- by calpain in acutely injured neuronal cells .
22537847	0	cdk5	18,22	p25	114,117	cdk5	p25	140908(Tax:10116)	170496(Tax:10116)	Gene	Gene	Crosstalk|nmod|START_ENTITY leads|nsubj|Crosstalk leads|nmod|upregulation upregulation|nmod|END_ENTITY	Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain .
22889803	0	cdk5	130,134	p25	136,139	cdk5	p25	1020	8851	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|nummod|END_ENTITY	Synthesis and structure-activity relationship of 4 - -LRB- 1,3-benzothiazol-2-yl -RRB- - thiophene-2-sulfonamides as cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- / p25 inhibitors .
10903889	0	cdk5	14,18	p35	29,32	cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	activator|amod|START_ENTITY Processing|nmod|activator END_ENTITY|nsubj|Processing	Processing of cdk5 activator p35 to its truncated form -LRB- p25 -RRB- by calpain in acutely injured neuronal cells .
11813240	0	cdk5	27,31	p35	87,90	cdk5	p35	1020	8851	Gene	Gene	activation|appos|START_ENTITY requires|nsubj|activation requires|nmod|domains domains|nmod|END_ENTITY	Cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activation requires interaction with three domains of p35 .
12393264	0	cdk5	80,84	p35	109,112	cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|proteolysis proteolysis|nmod|END_ENTITY	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
12393264	0	cdk5	80,84	p35	32,35	cdk5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
10683146	0	cdk5	14,18	p39	0,3	cdk5	p39	12568(Tax:10090)	12570(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	p39 activates cdk5 in neurons , and is associated with the actin cytoskeleton .
7759865	0	cdk6	88,92	PLSTIRE	44,51	cdk6	PLSTIRE	1021	1021	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Regulation of synthesis and activity of the PLSTIRE protein -LRB- cyclin-dependent_kinase_6 -LRB- cdk6 -RRB- -RRB- , a major cyclin D-associated cdk4 homologue in normal human T lymphocytes .
9029154	0	cdk7	38,42	cyclin_H	68,76	cdk7	cyclin H	399461(Tax:8355)	394356(Tax:8355)	Gene	Gene	T-loop|nmod|START_ENTITY phosphorylation|nmod|T-loop phosphorylation|dep|role role|nmod|END_ENTITY	Dual phosphorylation of the T-loop in cdk7 : its role in controlling cyclin_H binding and CAK activity .
22509363	0	cdkn1a	32,38	Miz1	0,4	cdkn1a	Miz1	1026	7709	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Miz1 is a critical repressor of cdkn1a during skin tumorigenesis .
23175770	0	cdkn2c	45,51	dmrta2	10,16	cdkn2c	dmrta2	555797(Tax:7955)	474350(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Zebrafish dmrta2 regulates the expression of cdkn2c in spermatogenesis in the adult testis .
20104269	0	cdx2	18,22	farnesoid_x_receptor	46,66	cdx2	farnesoid x receptor	66019(Tax:10116)	60351(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nmod|END_ENTITY	Bile_acids induce cdx2 expression through the farnesoid_x_receptor in gastric epithelial cells .
21597777	0	cea	72,75	carcinoembryonic_antigen	46,70	cea	carcinoembryonic antigen	1084	1084	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Tissue polypeptide antigen-specific -LRB- tps -RRB- and carcinoembryonic_antigen -LRB- cea -RRB- levels in cancerous and precancerous_lesions in human colon .
9395467	0	cea5	0,4	carcinoembryonic_antigen	52,76	cea5	carcinoembryonic antigen	26368(Tax:10090)	111518(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	cea5 , a structurally divergent member of the murine carcinoembryonic_antigen gene family , is exclusively expressed during early placental development in trophoblast giant cells .
11694347	0	cell-cell_adhesion_molecule-1	27,56	Ceacam1	58,65	cell-cell adhesion molecule-1	Ceacam1	634	634	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Androgen regulation of the cell-cell_adhesion_molecule-1 -LRB- Ceacam1 -RRB- gene .
23696594	0	cell-division_cycle_42	20,42	Cdc42	44,49	cell-division cycle 42	Cdc42	998	998	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Decreased levels of cell-division_cycle_42 -LRB- Cdc42 -RRB- protein in peripheral lymphocytes from ischaemic_stroke patients are associated with Golgi apparatus function .
18397887	0	cell_division_control_protein_6	38,69	phosphatase_2A	8,22	cell division control protein 6	phosphatase 2A	990	5524	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Protein phosphatase_2A is targeted to cell_division_control_protein_6 by a calcium-binding regulatory subunit .
12648761	0	cell_division_cycle_2	49,70	cdc2	72,76	cell division cycle 2	cdc2	983	983	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Increased frequency of a new polymorphism in the cell_division_cycle_2 -LRB- cdc2 -RRB- gene in patients with Alzheimer 's _ disease and frontotemporal_dementia .
22467868	0	cell_division_cycle_25_homolog_A	135,167	CDC25A	169,175	cell division cycle 25 homolog A	CDC25A	993	993	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lin-28_homologue_A -LRB- LIN28A -RRB- promotes cell cycle progression via regulation of cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- , cyclin_D1 -LRB- CCND1 -RRB- , and cell_division_cycle_25_homolog_A -LRB- CDC25A -RRB- expression in cancer .
17887956	0	cell_division_cycle_45	114,136	Cdc45	138,143	cell division cycle 45	Cdc45	8318	8318	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Characterization of the interaction between the human DNA_topoisomerase_IIbeta-binding_protein_1 -LRB- TopBP1 -RRB- and the cell_division_cycle_45 -LRB- Cdc45 -RRB- protein .
22549779	0	cell_division_cycle_48	19,41	CDC48	43,48	cell division cycle 48	CDC48	327197(Tax:7955)	327197(Tax:7955)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Protective role of cell_division_cycle_48 -LRB- CDC48 -RRB- protein against neurodegeneration_via_ubiquitin-proteasome_system_dysfunction during zebrafish development .
17338426	0	cell_secretory_protein	30,52	CC16	54,58	cell secretory protein	CC16	7356	7356	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between the clara cell_secretory_protein -LRB- CC16 -RRB- G38A polymorphism and the progression of IgA_nephropathy .
25700379	0	cell_secretory_protein-16	25,50	CC16	52,56	cell secretory protein-16	CC16	22287(Tax:10090)	22287(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Protective role for club cell_secretory_protein-16 -LRB- CC16 -RRB- in the development of chronic_obstructive_pulmonary_disease .
10486246	0	cell_surface_antigen	24,44	MRP8	79,83	cell surface antigen	MRP8	963	6279	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a B cell_surface_antigen with homology to the S100 protein MRP8 .
6265934	0	cell_surface_glycoprotein	6,31	transferrin	82,93	cell surface glycoprotein	transferrin	9308	7018	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Human cell_surface_glycoprotein related to cell proliferation is the receptor for transferrin .
18190721	0	cellular_FLICE-like_inhibitory_protein	44,82	TRAF2	15,20	cellular FLICE-like inhibitory protein	TRAF2	8837	7186	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|nmod|form	Association of TRAF2 with the short form of cellular_FLICE-like_inhibitory_protein prevents TNFR1-mediated apoptosis .
15025952	0	cellular_FLICE_inhibitory_protein	15,48	cFLIP	50,55	cellular FLICE inhibitory protein	cFLIP	8837	8837	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of cellular_FLICE_inhibitory_protein -LRB- cFLIP -RRB- in endometrial_adenocarcinoma -RSB- .
7829093	0	cellular_glutathione_peroxidase	67,98	GPX1	100,104	cellular glutathione peroxidase	GPX1	2876	2876	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An in-frame trinucleotide repeat in the coding region of the human cellular_glutathione_peroxidase -LRB- GPX1 -RRB- gene : in vivo polymorphism and in vitro instability .
18237028	0	cellular_glutathione_peroxidase	24,55	GPx-1	57,62	cellular glutathione peroxidase	GPx-1	2876	2876	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Homocysteine effects on cellular_glutathione_peroxidase -LRB- GPx-1 -RRB- activity under in vitro conditions .
10102298	0	cellular_retinaldehyde-binding_protein	45,83	RLBP1	90,95	cellular retinaldehyde-binding protein	RLBP1	6017	6017	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Bothnia_dystrophy caused by mutations in the cellular_retinaldehyde-binding_protein gene -LRB- RLBP1 -RRB- on chromosome 15q26 .
15234312	0	cellular_retinaldehyde-binding_protein	46,84	RLBP1	91,96	cellular retinaldehyde-binding protein	RLBP1	6017	6017	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel compound heterozygous mutation in the cellular_retinaldehyde-binding_protein gene -LRB- RLBP1 -RRB- in a patient with retinitis_punctata_albescens .
1351399	0	cellular_retinoic_acid-binding_protein_I	11,51	CRABP_I	53,60	cellular retinoic acid-binding protein I	CRABP I	12903(Tax:10090)	12903(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Domains of cellular_retinoic_acid-binding_protein_I -LRB- CRABP_I -RRB- expression in the hindbrain and neural crest of the mouse embryo .
7815831	0	cellular_retinoic_acid_binding_protein	56,94	CRABP	96,101	cellular retinoic acid binding protein	CRABP	1381	1381	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	In vitro all-trans_retinoic_acid -LRB- ATRA -RRB- sensitivity and cellular_retinoic_acid_binding_protein -LRB- CRABP -RRB- levels in relapse leukemic cells after remission induction by ATRA in acute_promyelocytic_leukemia .
8207983	0	cellular_retinoic_acid_binding_protein	56,94	CRABP	96,101	cellular retinoic acid binding protein	CRABP	1381	1381	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	In vitro all-trans_retinoic_acid -LRB- ATRA -RRB- sensitivity and cellular_retinoic_acid_binding_protein -LRB- CRABP -RRB- levels in relapse leukemic cells after remission induction by ATRA in acute_promyelocytic_leukemia .
9704013	0	cellular_retinoic_acid_binding_protein	14,52	CRABP_II	54,62	cellular retinoic acid binding protein	CRABP II	1382	1382	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of cellular_retinoic_acid_binding_protein -LRB- CRABP_II -RRB- during human monocyte differentiation in vitro .
12628590	0	cellular_retinoic_acid_binding_protein_II	65,106	CRABP-II	113,121	cellular retinoic acid binding protein II	CRABP-II	1382	1382	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two novel single nucleotide polymorphisms in the promoter of the cellular_retinoic_acid_binding_protein_II gene -LRB- CRABP-II -RRB- .
18052984	0	cellular_retinoic_acid_binding_protein_II	93,134	TPA-inducible_sequence_7	32,56	cellular retinoic acid binding protein II	TPA-inducible sequence 7	12904(Tax:10090)	15982(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	The transcriptional corepressor TPA-inducible_sequence_7 regulates adult axon growth through cellular_retinoic_acid_binding_protein_II expression .
7516425	0	cellular_retinol-binding_protein_I	19,53	CRBP_I	55,61	cellular retinol-binding protein I	CRBP I	25056(Tax:10116)	25056(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression of cellular_retinol-binding_protein_I -LRB- CRBP_I -RRB- is affected by dietary proteins in the rat liver .
19147806	0	cellular_retinol-binding_protein_type_II	49,89	Hepatocyte_nuclear_factor-4alpha	0,32	cellular retinol-binding protein type II	Hepatocyte nuclear factor-4alpha	5948	3172	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hepatocyte_nuclear_factor-4alpha regulates human cellular_retinol-binding_protein_type_II gene expression in intestinal cells .
12489168	0	cementum_attachment_protein	55,82	Bone_morphogenetic_protein_2	0,28	cementum attachment protein	Bone morphogenetic protein 2	9200	650	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Bone_morphogenetic_protein_2 induces the expression of cementum_attachment_protein in human periodontal ligament clones .
17037982	0	centaurin_gamma-1	4,21	NTPase	57,63	centaurin gamma-1	NTPase	116986	84284	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	The centaurin_gamma-1 GTPase-like domain functions as an NTPase .
10504299	0	centractin	47,57	Arp1alpha	36,45	centractin	Arp1alpha	10121	10121	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of normal and mutant Arp1alpha -LRB- centractin -RRB- differentially affects microtubule organization during mitosis and interphase .
12082570	0	central_cannabinoid_receptor	6,34	CNR1	0,4	central cannabinoid receptor	CNR1	1268	1268	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	CNR1 , central_cannabinoid_receptor gene , associated with susceptibility to hebephrenic_schizophrenia .
15108190	0	central_cannabinoid_receptor	52,80	CNR1	82,86	central cannabinoid receptor	CNR1	1268	1268	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Tourette_syndrome is not caused by mutations in the central_cannabinoid_receptor -LRB- CNR1 -RRB- gene .
23840880	0	centrin_2	33,42	CDC25B	0,6	centrin 2	CDC25B	1069	994	Gene	Gene	START_ENTITY|nsubj|stabilises stabilises|compound|END_ENTITY	CDC25B overexpression stabilises centrin_2 and promotes the formation of excess centriolar foci .
16956364	0	centrin_2	17,26	hSfi1	54,59	centrin 2	hSfi1	1069	9814	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of human centrin_2 to the centrosomal protein hSfi1 .
23816042	0	centromere-associated_protein-E	21,52	CENP-E	54,60	centromere-associated protein-E	CENP-E	1062	1062	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthetic studies of centromere-associated_protein-E -LRB- CENP-E -RRB- inhibitors : 1 .
17535814	0	centromere-associated_protein_E	26,57	NUF2	6,10	centromere-associated protein E	NUF2	1062	83540	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human NUF2 interacts with centromere-associated_protein_E and is essential for a stable spindle microtubule-kinetochore attachment .
18460473	0	centromere-associated_protein_E	24,55	Septin_7	0,8	centromere-associated protein E	Septin 7	1062	989	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Septin_7 interacts with centromere-associated_protein_E and is required for its kinetochore localization .
11129795	0	centromere_protein_A	45,65	CENP-A	67,73	centromere protein A	CENP-A	1058	1058	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Centromere/kinetochore localization of human centromere_protein_A -LRB- CENP-A -RRB- exogenously expressed as a fusion to green fluorescent protein .
11925107	0	centromere_protein_C	72,92	CENP-C	95,101	centromere protein C	CENP-C	1060	1060	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Mutational analysis of the central centromere targeting domain of human centromere_protein_C , -LRB- CENP-C -RRB- .
20140237	0	centromere_protein_C	15,35	CENPC	37,42	centromere protein C	CENPC	1060	1060	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	DNA binding of centromere_protein_C -LRB- CENPC -RRB- is stabilized by single-stranded RNA .
20053638	0	centromere_protein_F	70,90	Cdc20	0,5	centromere protein F	Cdc20	1063	991	Gene	Gene	degradation|nmod|START_ENTITY required|nmod|degradation required|nsubjpass|END_ENTITY	Cdc20 is required for the post-anaphase , KEN-dependent degradation of centromere_protein_F .
17028323	0	centromeric_histone_H3	15,37	HTR12	39,44	centromeric histone H3	HTR12	839104(Tax:3702)	839104(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Duplication of centromeric_histone_H3 -LRB- HTR12 -RRB- gene in Arabidopsis halleri and A. lyrata , plant species with multiple centromeric satellite sequences .
19427213	0	centrosomin	29,40	Centrocortin	0,12	centrosomin	Centrocortin	36491(Tax:7227)	35330(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|compound|END_ENTITY	Centrocortin cooperates with centrosomin to organize Drosophila embryonic cleavage furrows .
18498074	0	cerbB-2	42,49	cyclin-D1	31,40	cerbB-2	cyclin-D1	2064	595	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Prognostic index expression of cyclin-D1 , cerbB-2 and VEGF : metastases vs corresponding primary cancers and metastatic vs non-metastatic adenocarcinomas .
19211811	0	cerebellin_4_precursor	4,26	SRY	54,57	cerebellin 4 precursor	SRY	228942(Tax:10090)	21674(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	The cerebellin_4_precursor gene is a direct target of SRY and SOX9 in mice .
6136972	0	cerebroside_sulfatase	89,110	arylsulfatase_A	72,87	cerebroside sulfatase	arylsulfatase A	410	410	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Juvenile and adult metachromatic_leukodystrophy : partial restoration of arylsulfatase_A -LRB- cerebroside_sulfatase -RRB- activity by inhibitors of thiol proteinases .
22431521	0	ceroid_lipofuscinosis_neuronal_protein_5	12,52	CLN5	54,58	ceroid lipofuscinosis neuronal protein 5	CLN5	1203	1203	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of ceroid_lipofuscinosis_neuronal_protein_5 -LRB- CLN5 -RRB- in endosomal sorting .
9988272	0	ceruloplasmin	14,27	Hephaestin	0,10	ceruloplasmin	Hephaestin	12870(Tax:10090)	15203(Tax:10090)	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Hephaestin , a ceruloplasmin homologue implicated in intestinal iron transport , is defective in the sla mouse .
12547227	0	ceruloplasmin	4,17	hephaestin	26,36	ceruloplasmin	hephaestin	12870(Tax:10090)	15203(Tax:10090)	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption .
15174093	0	cftr	76,80	peroxisome_proliferator_activated_receptor_gamma	24,72	cftr	peroxisome proliferator activated receptor gamma	12638(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of peroxisome_proliferator_activated_receptor_gamma in cftr - / - mice .
24854858	0	chaperonin	22,32	CCT	33,36	chaperonin	CCT	432551(Tax:10090)	21454(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	Essential role of the chaperonin CCT in rod outer segment biogenesis .
8901050	0	chaperonin	47,57	CCT_gamma	34,43	chaperonin	CCT gamma	399217(Tax:8355)	380506(Tax:8355)	Gene	Gene	subunit|compound|START_ENTITY END_ENTITY|appos|subunit	Cloning and expression of Xenopus CCT_gamma , a chaperonin subunit developmentally regulated in neural-derived and myogenic lineages .
16151221	0	chaperonin_10	20,33	Cpn10	35,40	chaperonin 10	Cpn10	3336	3336	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of chaperonin_10 -LRB- Cpn10 -RRB- from the intestinal human pathogen Entamoeba_histolytica .
7927265	0	chaperonin_10	98,111	Early_pregnancy_factor	0,22	chaperonin 10	Early pregnancy factor	25462(Tax:10116)	3336	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Early_pregnancy_factor in liver_regeneration after partial hepatectomy in rats : relationship with chaperonin_10 .
7902576	0	chaperonin_10	42,55	groES	61,66	chaperonin 10	groES	854185(Tax:4932)	13876916	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Identification and functional analysis of chaperonin_10 , the groES homolog from yeast mitochondria .
8661059	0	chaperonin_containing_TCP-1	89,116	Cct4	118,122	chaperonin containing TCP-1	Cct4	12464(Tax:10090)	12464(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal assignment and imprinting tests for the mouse delta subunit of the cytosolic chaperonin_containing_TCP-1 -LRB- Cct4 -RRB- gene to proximal chromosome 11 .
21502314	0	checkpoint_kinase_1	199,218	ATR	175,178	checkpoint kinase 1	ATR	1111	545	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
22529391	0	checkpoint_kinase_1	31,50	Chk1	52,56	checkpoint kinase 1	Chk1	1111	1111	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Kinase-independent function of checkpoint_kinase_1 -LRB- Chk1 -RRB- in the replication of damaged DNA .
21502314	0	checkpoint_kinase_1	199,218	ataxia-telangiectasia_mutated_and_RAD3-related	127,173	checkpoint kinase 1	ataxia-telangiectasia mutated and RAD3-related	1111	545	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 -LRB- TopBP1 -RRB- and Claspin to DNA activates ataxia-telangiectasia_mutated_and_RAD3-related -LRB- ATR -RRB- phosphorylation of checkpoint_kinase_1 -LRB- Chk1 -RRB- .
12654916	0	checkpoint_kinase_2	24,43	p53	51,54	checkpoint kinase 2	p53	11200	7157	Gene	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Questioning the role of checkpoint_kinase_2 in the p53 DNA damage response .
14516774	0	checkpoint_kinase_2	30,49	p53	64,67	checkpoint kinase 2	p53	50883(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Tissue-specific regulation of checkpoint_kinase_2 expression by p53 .
22071692	0	checkpoint_kinase_2	48,67	p53	78,81	checkpoint kinase 2	p53	11200	7157	Gene	Gene	protein|nmod|START_ENTITY Phosphorylation|nmod|protein regulates|nsubj|Phosphorylation regulates|dobj|transactivation transactivation|compound|END_ENTITY	Phosphorylation of von_Hippel-Lindau protein by checkpoint_kinase_2 regulates p53 transactivation .
18794339	0	chemerin	48,56	CCRL2	36,41	chemerin	CCRL2	71660(Tax:10090)	54199(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis .
18794339	0	chemerin	48,56	CCRL2	36,41	chemerin	CCRL2	71660(Tax:10090)	54199(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis .
22696441	0	chemerin	49,57	CCRL2	67,72	chemerin	CCRL2	71660(Tax:10090)	54199(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression , regulation , and function of atypical chemerin receptor CCRL2 on endothelial cells .
19540290	0	chemerin	27,35	ChemR23	71,78	chemerin	ChemR23	71660(Tax:10090)	14747(Tax:10090)	Gene	Gene	analog|compound|START_ENTITY Identification|nmod|analog Identification|nmod|END_ENTITY	Identification of a stable chemerin analog with potent activity toward ChemR23 .
21192818	0	chemerin	124,132	ChemR23	37,44	chemerin	ChemR23	5919	1240	Gene	Gene	promotes|nmod|START_ENTITY express|parataxis|promotes express|dobj|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
21192818	0	chemerin	124,132	ChemR23	37,44	chemerin	ChemR23	5919	1240	Gene	Gene	promotes|nmod|START_ENTITY express|parataxis|promotes express|dobj|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
21192818	0	chemerin	124,132	ChemR23	59,66	chemerin	ChemR23	5919	1240	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
21192818	0	chemerin	124,132	ChemR23	59,66	chemerin	ChemR23	5919	1240	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Human articular chondrocytes express ChemR23 and chemerin ; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin -LRB- 21-157 -RRB- .
25637017	0	chemerin	26,34	ChemR23	0,7	chemerin	ChemR23	5919	1240	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	ChemR23 , the receptor for chemerin and resolvin_E1 , is expressed and functional on M1 but not on M2 macrophages .
25637017	0	chemerin	26,34	ChemR23	0,7	chemerin	ChemR23	5919	1240	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	ChemR23 , the receptor for chemerin and resolvin_E1 , is expressed and functional on M1 but not on M2 macrophages .
24779513	0	chemerin	100,108	Chemerin	0,8	chemerin	Chemerin	5919	5919	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Chemerin and CMKLR1 expression in human arteries and periadventitial fat : a possible role for local chemerin in atherosclerosis ?
24779513	0	chemerin	100,108	Chemerin	0,8	chemerin	Chemerin	5919	5919	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Chemerin and CMKLR1 expression in human arteries and periadventitial fat : a possible role for local chemerin in atherosclerosis ?
23507574	0	chemerin	18,26	FXR	38,41	chemerin	FXR	71660(Tax:10090)	20186(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic_steatohepatitis .
23507574	0	chemerin	18,26	FXR	38,41	chemerin	FXR	71660(Tax:10090)	20186(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Identification of chemerin as a novel FXR target gene down-regulated in the progression of nonalcoholic_steatohepatitis .
19233230	0	chemerin	46,54	Interleukin-1beta	0,17	chemerin	Interleukin-1beta	71660(Tax:10090)	16176(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro .
24716552	0	chemerin	34,42	chemerin	4,12	chemerin	chemerin	297073(Tax:10116)	297073(Tax:10116)	Gene	Gene	agonist|appos|START_ENTITY agonist|compound|END_ENTITY	The chemerin receptor 23 agonist , chemerin , attenuates monosynaptic C-fibre input to lamina I neurokinin_1_receptor expressing rat spinal cord neurons in inflammatory_pain .
24716552	0	chemerin	4,12	chemerin	34,42	chemerin	chemerin	297073(Tax:10116)	297073(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	The chemerin receptor 23 agonist , chemerin , attenuates monosynaptic C-fibre input to lamina I neurokinin_1_receptor expressing rat spinal cord neurons in inflammatory_pain .
22154272	0	chemerin	164,172	tumor_necrosis_factor-a	114,137	chemerin	tumor necrosis factor-a	5919	7124	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increased levels of chemerin_and_its_receptor , _ chemokine-like_receptor-1 , in obesity are related to inflammation : tumor_necrosis_factor-a stimulates mRNA levels of chemerin in visceral adipocytes from obese patients .
22154272	0	chemerin	164,172	tumor_necrosis_factor-a	114,137	chemerin	tumor necrosis factor-a	5919	7124	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increased levels of chemerin_and_its_receptor , _ chemokine-like_receptor-1 , in obesity are related to inflammation : tumor_necrosis_factor-a stimulates mRNA levels of chemerin in visceral adipocytes from obese patients .
15792532	0	chemerin_receptor	10,27	mcmklr1	34,41	chemerin receptor	mcmklr1	14747(Tax:10090)	14747(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse chemerin_receptor gene , mcmklr1 , utilizes alternative promoters for transcription and is regulated by all-trans_retinoic_acid .
17437532	0	chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells	21,100	CRTH2	102,107	chemoattractant receptor-homologous molecule expressed on T helper type 2 cells	CRTH2	11251	11251	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A paracrine role for chemoattractant_receptor-homologous_molecule_expressed_on_T_helper_type_2_cells -LRB- CRTH2 -RRB- in mediating chemotactic activation of CRTH2 + CD4 + T helper type 2 lymphocytes .
17196174	0	chemoattractant_receptor-homologous_molecule_expressed_on_Th2_cells	46,113	CRTH2	115,120	chemoattractant receptor-homologous molecule expressed on Th2 cells	CRTH2	11251	11251	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of PI3K and calcineurin suppresses chemoattractant_receptor-homologous_molecule_expressed_on_Th2_cells -LRB- CRTH2 -RRB- - dependent responses of Th2 lymphocytes to prostaglandin_D -LRB- 2 -RRB- .
22186410	0	chemokine-like_receptor-1	18,43	CMKLR1	45,51	chemokine-like receptor-1	CMKLR1	14747(Tax:10090)	14747(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of the chemokine-like_receptor-1 -LRB- CMKLR1 -RRB- gene is associated with reduced adiposity and glucose_intolerance .
21955359	0	chemokine_BRAK	4,18	CXCL14	19,25	chemokine BRAK	CXCL14	57266(Tax:10090)	57266(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	The chemokine_BRAK / CXCL14 regulates synaptic transmission in the adult mouse dentate gyrus stem cell niche .
10229797	0	chemokine_TECK	100,114	CCR9	73,77	chemokine TECK	CCR9	6370	10803	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Cutting edge : identification of the orphan chemokine receptor GPR-9-6 as CCR9 , the receptor for the chemokine_TECK .
16461304	0	chemokine_receptor	25,43	CCR1	45,49	chemokine receptor	CCR1	7852	1230	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical significance of chemokine_receptor -LRB- CCR1 , CCR2 and CXCR4 -RRB- expression in human myeloma cells : the association with disease activity and survival .
10477627	0	chemokine_receptor	22,40	CCR2	17,21	chemokine receptor	CCR2	7852	729230	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Up-regulation of CCR2 chemokine_receptor expression and increased susceptibility to the multitropic HIV_strain 89.6 in monocytes exposed to glucocorticoid hormones .
16461304	0	chemokine_receptor	25,43	CCR2	51,55	chemokine receptor	CCR2	7852	729230	Gene	Gene	expression|amod|START_ENTITY expression|appos|CCR1 CCR1|dep|END_ENTITY	Clinical significance of chemokine_receptor -LRB- CCR1 , CCR2 and CXCR4 -RRB- expression in human myeloma cells : the association with disease activity and survival .
19913021	0	chemokine_receptor	14,32	CCR2	109,113	chemokine receptor	CCR2	574188(Tax:9544)	574098(Tax:9544)	Gene	Gene	Assessment|nmod|START_ENTITY function|nsubj|Assessment function|nmod|evaluations evaluations|nmod|antagonist antagonist|compound|END_ENTITY	Assessment of chemokine_receptor function on monocytes in whole blood : In vitro and ex vivo evaluations of a CCR2 antagonist .
9365120	0	chemokine_receptor	19,37	CCR2	14,18	chemokine receptor	CCR2	7852	729230	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CCR2 chemokine_receptor mRNA stability .
11213625	0	chemokine_receptor	55,73	CCR5	50,54	chemokine receptor	CCR5	7852	1234	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Distribution of the 32 base pair deletion of the CCR5 chemokine_receptor gene in different regions of Ukraine -RSB- .
11994442	0	chemokine_receptor	12,30	CCR5	110,114	chemokine receptor	CCR5	7852	1234	Gene	Gene	expression|compound|START_ENTITY expression|nmod|lymphocytes lymphocytes|dep|expression expression|nmod|END_ENTITY	Patterns of chemokine_receptor expression on peripheral blood gamma delta T lymphocytes : strong expression of CCR5 is a selective feature of V delta 2/V gamma 9 gamma delta T cells .
20801883	0	chemokine_receptor	52,70	CCR5	81,85	chemokine receptor	CCR5	7852	1234	Gene	Gene	internalization|amod|START_ENTITY internalization|compound|END_ENTITY	Na + / H + exchanger regulatory factor-1 is involved in chemokine_receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer .
22815758	0	chemokine_receptor	80,98	CCR5	75,79	chemokine receptor	CCR5	7852	1234	Gene	Gene	START_ENTITY|nsubj|chaperone chaperone|nmod|END_ENTITY	Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine_receptor signaling complex organization .
9480225	0	chemokine_receptor	80,98	CCR5	99,103	chemokine receptor	CCR5	7852	1234	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A simple and rapid method for determining a 32-bp deletion in the gene for the chemokine_receptor CCR5 -RSB- .
11056676	0	chemokine_receptor	33,51	CD4	77,80	chemokine receptor	CD4	7852	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Cytokine , activation marker , and chemokine_receptor expression by individual CD4 -LRB- + -RRB- memory T cells in rheumatoid_arthritis synovium .
11086103	0	chemokine_receptor	34,52	CD4	91,94	chemokine receptor	CD4	7852	920	Gene	Gene	play|nsubj|START_ENTITY play|dobj|role role|nmod|accumulation accumulation|compound|END_ENTITY	Stromal cell-derived factor-1-CXC chemokine_receptor 4 interactions play a central role in CD4 + T cell accumulation in rheumatoid_arthritis synovium .
12699425	0	chemokine_receptor	24,42	CD4	70,73	chemokine receptor	CD4	7852	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	CCR4 is an up-regulated chemokine_receptor of peripheral blood memory CD4 + T cells in Crohn 's _ disease .
15178707	0	chemokine_receptor	43,61	CD4	82,85	chemokine receptor	CD4	7852	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Lysophosphatidylcholine up-regulates CXCR4 chemokine_receptor expression in human CD4 T cells .
22471287	0	chemokine_receptor	40,58	CD4	73,76	chemokine receptor	CD4	7852	920	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|advcl|circulating circulating|nsubj|subsets subsets|compound|END_ENTITY	Cyclosporin but not everolimus inhibits chemokine_receptor expression on CD4 + T cell subsets circulating in the peripheral blood of renal transplant recipients .
9670042	0	chemokine_receptor	163,181	CD4	0,3	chemokine receptor	CD4	7852	920	Gene	Gene	expression|nmod|START_ENTITY express|dobj|expression instructs|xcomp|express cytokine|parataxis|instructs cytokine|nsubj|cell cell|compound|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
9670042	0	chemokine_receptor	163,181	CD4	92,95	chemokine receptor	CD4	7852	920	Gene	Gene	expression|nmod|START_ENTITY express|dobj|expression instructs|xcomp|express instructs|dobj|cells cells|compound|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
22731642	0	chemokine_receptor	52,70	CX3CR1	71,77	chemokine receptor	CX3CR1	7852	1524	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Association of V249I and T280M polymorphisms in the chemokine_receptor CX3CR1 gene with early onset of coronary_artery_disease among North Indians .
11080597	0	chemokine_receptor	40,58	CXCR1	86,91	chemokine receptor	CXCR1	419784(Tax:9031)	430652(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of a new chemokine_receptor gene , the putative chicken CXCR1 .
19446732	0	chemokine_receptor	20,38	CXCR2	108,113	chemokine receptor	CXCR2	7852	3579	Gene	Gene	proteins|amod|START_ENTITY Characterization|nmod|proteins approach|nsubj|Characterization approach|xcomp|define define|xcomp|chemosynapse chemosynapse|dep|END_ENTITY	Characterization of chemokine_receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 `` chemosynapse '' .
19446732	0	chemokine_receptor	20,38	CXCR2	39,44	chemokine receptor	CXCR2	7852	3579	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Characterization of chemokine_receptor CXCR2 interacting proteins using a proteomics approach to define the CXCR2 `` chemosynapse '' .
15178707	0	chemokine_receptor	43,61	CXCR4	37,42	chemokine receptor	CXCR4	7852	7852	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Lysophosphatidylcholine up-regulates CXCR4 chemokine_receptor expression in human CD4 T cells .
21448932	0	chemokine_receptor	115,133	CXCR4	109,114	chemokine receptor	CXCR4	7852	7852	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Acetyl-11-keto-b-boswellic_acid suppresses invasion of pancreatic_cancer cells through the downregulation of CXCR4 chemokine_receptor expression .
9670042	0	chemokine_receptor	163,181	interleukin_4	115,128	chemokine receptor	interleukin 4	7852	3565	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
16288025	0	chemokine_receptor	64,82	tumor_necrosis_factor-alpha	26,53	chemokine receptor	tumor necrosis factor-alpha	7852	7124	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The inflammatory cytokine tumor_necrosis_factor-alpha regulates chemokine_receptor expression on ovarian_cancer cells .
16879946	0	chemokine_receptor_5	77,97	CCR5	99,103	chemokine receptor 5	CCR5	1234	1234	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A closed-tube assay for genotyping of the 32-bp deletion polymorphism in the chemokine_receptor_5 -LRB- CCR5 -RRB- gene : dissociation analysis of amplified fragments of DNA .
17067435	0	chemokine_receptor_5	15,35	CCR5	37,41	chemokine receptor 5	CCR5	1234	1234	Gene	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	Association of chemokine_receptor_5 -LRB- CCR5 -RRB- delta32 mutation with Beh __ et 's _ disease is dependent on gender in Iranian patients .
18179389	0	chemokine_receptor_5	18,38	CCR5	40,44	chemokine receptor 5	CCR5	1234	1234	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A deletion in the chemokine_receptor_5 -LRB- CCR5 -RRB- gene is associated with tickborne encephalitis .
25785041	0	chemokine_receptor_5	20,40	CCR5	42,46	chemokine receptor 5	CCR5	1234	1234	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Association between chemokine_receptor_5 -LRB- CCR5 -RRB- delta32 gene variant and atherosclerosis : a meta-analysis of 13 studies .
21165582	0	chemokine_receptor_7	14,34	Cdc42	109,114	chemokine receptor 7	Cdc42	1236	998	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	CCL19-induced chemokine_receptor_7 activates the phosphoinositide-3_kinase-mediated invasive pathway through Cdc42 in metastatic squamous_cell_carcinoma_of_the_head_and_neck .
11784326	0	chicken_ovalbumin_upstream_promoter-transcription_factor_I	13,71	COUP-TFI	73,81	chicken ovalbumin upstream promoter-transcription factor I	COUP-TFI	100859519	100859519	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|END_ENTITY	Induction of chicken_ovalbumin_upstream_promoter-transcription_factor_I -LRB- COUP-TFI -RRB- gene expression is mediated by ETS factor binding sites .
18387660	0	chicken_ovalbumin_upstream_promoter-transcription_factor_I	14,72	COUP-TFI	74,82	chicken ovalbumin upstream promoter-transcription factor I	COUP-TFI	100859519	100859519	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of chicken_ovalbumin_upstream_promoter-transcription_factor_I -LRB- COUP-TFI -RRB- in bladder_transitional_cell_carcinoma .
12525252	0	chicken_ovalbumin_upstream_promoter-transcription_factor_II	45,104	COUP-TFII	106,115	chicken ovalbumin upstream promoter-transcription factor II	COUP-TFII	386585(Tax:9031)	386585(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activation of the MAP kinase pathway induces chicken_ovalbumin_upstream_promoter-transcription_factor_II -LRB- COUP-TFII -RRB- expression in human breast_cancer cell lines .
22493443	0	chicken_ovalbumin_upstream_promoter-transcription_factor_II	24,83	COUP-TFII	85,94	chicken ovalbumin upstream promoter-transcription factor II	COUP-TFII	386585(Tax:9031)	386585(Tax:9031)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Orphan nuclear receptor chicken_ovalbumin_upstream_promoter-transcription_factor_II -LRB- COUP-TFII -RRB- protein negatively regulates bone_morphogenetic_protein_2-induced osteoblast differentiation through suppressing runt-related gene 2 -LRB- Runx2 -RRB- activity .
16098962	0	chitin_synthase	4,19	chs-1	26,31	chitin synthase	chs-1	173405(Tax:6239)	172508(Tax:6239)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	The chitin_synthase genes chs-1 and chs-2 are essential for C. _ elegans development and responsible for chitin deposition in the eggshell and pharynx , respectively .
9745020	0	chitinase	28,37	CTS1	22,26	chitinase	CTS1	850992(Tax:4932)	850992(Tax:4932)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Ace2p , a regulator of CTS1 -LRB- chitinase -RRB- expression , affects pseudohyphal production in Saccharomyces_cerevisiae .
23439988	0	chitinase_1	25,36	chitotriosidase	8,23	chitinase 1	chitotriosidase	1118	1118	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of chitotriosidase -LRB- chitinase_1 -RRB- under normal and disease conditions .
19414556	0	chitinase_3-like-1	46,64	breast_regression_protein_39	8,36	chitinase 3-like-1	breast regression protein 39	12654(Tax:10090)	12654(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|amod|END_ENTITY	Role of breast_regression_protein_39 -LRB- BRP-39 -RRB- / chitinase_3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis .
24958781	0	chitinase_3-like_1	90,108	CHI3L1	115,121	chitinase 3-like 1	CHI3L1	1116	1116	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40 , variation in the chitinase_3-like_1 gene -LRB- CHI3L1 -RRB- , and incident cardiovascular events .
12435396	0	chitinase_3-like_2	33,51	YKL-39	58,64	chitinase 3-like 2	YKL-39	1117	1117	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Enhanced expression of the human chitinase_3-like_2 gene -LRB- YKL-39 -RRB- but not chitinase_3-like_1 gene -LRB- YKL-40 -RRB- in osteoarthritic cartilage .
19415692	0	chitotriosidase	18,33	PI3-K	79,84	chitotriosidase	PI3-K	1118	5293	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Prolactin induces chitotriosidase expression in human macrophages through PTK , PI3-K , and MAPK pathways .
15234536	0	chitotriosidase	18,33	Prolactin	0,9	chitotriosidase	Prolactin	1118	5617	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Prolactin induces chitotriosidase gene expression in human monocyte-derived macrophages .
19415692	0	chitotriosidase	18,33	Prolactin	0,9	chitotriosidase	Prolactin	1118	5617	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Prolactin induces chitotriosidase expression in human macrophages through PTK , PI3-K , and MAPK pathways .
23439988	0	chitotriosidase	8,23	chitinase_1	25,36	chitotriosidase	chitinase 1	1118	1118	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of chitotriosidase -LRB- chitinase_1 -RRB- under normal and disease conditions .
9760750	0	chloramphenicol_acetyltransferase	28,61	CAT	63,66	chloramphenicol acetyltransferase	CAT	8319152(Tax:562)	8319152(Tax:562)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The low level expression of chloramphenicol_acetyltransferase -LRB- CAT -RRB- mRNA in Escherichia_coli is not dependent on either Shine-Dalgarno or the downstream boxes in the CAT gene .
10937437	0	chloramphenicol_acetyltransferase	65,98	OmpT	0,4	chloramphenicol acetyltransferase	OmpT	8319152(Tax:562)	3853531(Tax:562)	Gene	Gene	response|nmod|START_ENTITY expression|nmod|response expression|amod|END_ENTITY	OmpT expression and activity increase in response to recombinant chloramphenicol_acetyltransferase overexpression and heat_shock in E. _ coli .
11709351	0	chloramphenicol_acetyltransferase	65,98	cat	100,103	chloramphenicol acetyltransferase	cat	8319152(Tax:562)	8319152(Tax:562)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chloramphenicol-sensitive Escherichia_coli_strain expressing the chloramphenicol_acetyltransferase -LRB- cat -RRB- gene .
17156979	0	chloride_channel_2	18,36	CLCN2	38,43	chloride channel 2	CLCN2	1181	1181	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Quantification of chloride_channel_2 -LRB- CLCN2 -RRB- gene isoforms in normal versus lesion - and epilepsy-associated brain tissue .
25546839	0	chloride_intracellular_channel_1_and_4	38,76	CLIC1	78,83	chloride intracellular channel 1 and 4	CLIC1	1192;25932	1192	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Chloride channels in cancer : Focus on chloride_intracellular_channel_1_and_4 -LRB- CLIC1 AND CLIC4 -RRB- proteins in tumor development and as novel therapeutic targets .
24886590	0	chloride_intracellular_channel_4	56,88	CLIC4	90,95	chloride intracellular channel 4	CLIC4	29876(Tax:10090)	29876(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Detection of differential fetal and adult expression of chloride_intracellular_channel_4 -LRB- CLIC4 -RRB- protein by analysis of a green fluorescent protein knock-in mouse line .
3676777	0	cholecalcin	58,69	CaBP	71,75	cholecalcin	CaBP	24249(Tax:10116)	29177(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The comparative immunocytochemical distribution of 28 kDa cholecalcin -LRB- CaBP -RRB- in the hippocampus of rat , guinea_pig and hedgehog .
4027624	0	cholecalcin	5,16	CaBP	18,22	cholecalcin	CaBP	24249(Tax:10116)	12309(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	28 K cholecalcin -LRB- CaBP -RRB- levels in abnormal cerebella : studies on mutant mice and harmaline - and 3-acetylpyridine-treated rats .
10536208	0	cholecystokinin	78,93	C-fos	0,5	cholecystokinin	C-fos	25298(Tax:10116)	314322(Tax:10116)	Gene	Gene	injected|compound|START_ENTITY correlates|nmod|injected correlates|nsubj|expression expression|amod|END_ENTITY	C-fos protein expression in the nucleus of the solitary tract correlates with cholecystokinin dose injected and food intake in rats .
1557514	0	cholecystokinin	24,39	CCK	41,44	cholecystokinin	CCK	885	885	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of plasma cholecystokinin -LRB- CCK -RRB- concentrations by bioassay and radioimmunoassay in man .
18462884	0	cholecystokinin	23,38	CCK	40,43	cholecystokinin	CCK	12424(Tax:10090)	12424(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Prenatal expression of cholecystokinin -LRB- CCK -RRB- in the central nervous system -LRB- CNS -RRB- of mouse .
22849841	0	cholecystokinin	30,45	CCK	47,50	cholecystokinin	CCK	25298(Tax:10116)	25298(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Anorexic effect of peripheral cholecystokinin -LRB- CCK -RRB- varies with age and body composition -LRB- short communication -RRB- .
3773639	0	cholecystokinin	55,70	CCK	72,75	cholecystokinin	CCK	12424(Tax:10090)	12424(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	A new simple mouse model for the in vivo evaluation of cholecystokinin -LRB- CCK -RRB- antagonists : comparative potencies and durations of action of nonpeptide antagonists .
6522644	0	cholecystokinin	49,64	CCK	66,69	cholecystokinin	CCK	885	885	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and heterogeneity of immunoreactive cholecystokinin -LRB- CCK -RRB- in the mucosa of the porcine gastrointestinal tract .
8432795	0	cholecystokinin	21,36	CCK	134,137	cholecystokinin	CCK	885	885	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Reduced postprandial cholecystokinin -LRB- CCK -RRB- secretion in patients with noninsulin-dependent_diabetes_mellitus : evidence for a role for CCK in regulating postprandial hyperglycemia .
8552311	0	cholecystokinin	20,35	CCK	37,40	cholecystokinin	CCK	25298(Tax:10116)	25298(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Impaired release of cholecystokinin -LRB- CCK -RRB- from synaptosomes in old rats .
16105969	0	cholecystokinin	41,56	CCK1	36,40	cholecystokinin	CCK1	885	56477	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Immunohistochemical localization of CCK1 cholecystokinin receptors in normal and neoplastic human tissues .
23399917	0	cholecystokinin	22,37	CLOCK	41,46	cholecystokinin	CLOCK	12424(Tax:10090)	12753(Tax:10090)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	An important role for cholecystokinin , a CLOCK target gene , in the development and treatment of manic-like behaviors .
15030385	0	cholecystokinin	46,61	CREB	107,111	cholecystokinin	CREB	885	1385	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	KCl and forskolin synergistically up-regulate cholecystokinin gene expression via coordinate activation of CREB and the co-activator CBP .
1466765	0	cholecystokinin	42,57	Enkephalin	0,10	cholecystokinin	Enkephalin	25298(Tax:10116)	29237(Tax:10116)	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Enkephalin is a competitive antagonist of cholecystokinin in the gastrointestinal tract , as predicted from prior conformational analysis .
7488089	0	cholecystokinin	17,32	Galanin	0,7	cholecystokinin	Galanin	12424(Tax:10090)	14419(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Galanin inhibits cholecystokinin secretion in STC-1 cells .
23863714	0	cholecystokinin	73,88	Immunoglobulin-like_domain_containing_receptor_1	0,48	cholecystokinin	Immunoglobulin-like domain containing receptor 1	12424(Tax:10090)	106347(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Immunoglobulin-like_domain_containing_receptor_1 mediates fat-stimulated cholecystokinin secretion .
10422768	0	cholecystokinin	38,53	Leptin	0,6	cholecystokinin	Leptin	25298(Tax:10116)	25608(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Leptin in gastroprotection induced by cholecystokinin or by a meal .
15734493	0	cholecystokinin	46,61	Leptin	0,6	cholecystokinin	Leptin	12424(Tax:10090)	16846(Tax:10090)	Gene	Gene	response|acl|START_ENTITY increases|dobj|response increases|nsubj|END_ENTITY	Leptin increases small intestinal response to cholecystokinin in leptin-deficient_obese_mice .
22412960	0	cholecystokinin	53,68	Leptin	0,6	cholecystokinin	Leptin	25298(Tax:10116)	25608(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY inhibits|dobj|signaling inhibits|nsubj|resistance resistance|compound|END_ENTITY	Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats .
21311026	0	cholecystokinin	28,43	PepT1	147,152	cholecystokinin	PepT1	25298(Tax:10116)	117261(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY mediated|nsubjpass|secretion mediated|nmod|END_ENTITY	Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1 .
19896983	0	cholecystokinin	38,53	STC-1	114,119	cholecystokinin	STC-1	885	6781	Gene	Gene	START_ENTITY|dobj|secretion secretion|nmod|receptor receptor|nmod|cells cells|compound|END_ENTITY	Soybean beta 51-63 peptide stimulates cholecystokinin secretion via a calcium-sensing receptor in enteroendocrine STC-1 cells .
20352619	0	cholecystokinin	52,67	STC-1	121,126	cholecystokinin	STC-1	885	6781	Gene	Gene	expression|amod|START_ENTITY fatty_acids|nmod|expression fatty_acids|nmod|cells cells|compound|END_ENTITY	Acute and chronic effects of dietary fatty_acids on cholecystokinin expression , storage and secretion in enteroendocrine STC-1 cells .
24741397	0	cholecystokinin	22,37	STC-1	51,56	cholecystokinin	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Naringenin stimulates cholecystokinin secretion in STC-1 cells .
7488089	0	cholecystokinin	17,32	STC-1	46,51	cholecystokinin	STC-1	12424(Tax:10090)	20855(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Galanin inhibits cholecystokinin secretion in STC-1 cells .
7977748	0	cholecystokinin	14,29	STC-1	55,60	cholecystokinin	STC-1	885	6781	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|bombesin bombesin|nmod|cells cells|compound|END_ENTITY	Regulation of cholecystokinin secretion by bombesin in STC-1 cells .
8167157	0	cholecystokinin	35,50	STC-1	97,102	cholecystokinin	STC-1	12424(Tax:10090)	20855(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY Characterization|nmod|release Characterization|nmod|line line|appos|END_ENTITY	Characterization of the release of cholecystokinin from a murine neuroendocrine_tumor cell line , STC-1 .
8216272	0	cholecystokinin	28,43	STC-1	57,62	cholecystokinin	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY regulate|dobj|secretion regulate|nmod|cells cells|compound|END_ENTITY	Potassium channels regulate cholecystokinin secretion in STC-1 cells .
8779970	0	cholecystokinin	26,41	STC-1	94,99	cholecystokinin	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY mediated|nsubjpass|secretion mediated|nmod|channels channels|nmod|cells cells|compound|END_ENTITY	Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells .
8779971	0	cholecystokinin	30,45	STC-1	59,64	cholecystokinin	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY regulation|nmod|secretion regulation|nmod|cells cells|compound|END_ENTITY	Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells .
9048620	0	cholecystokinin	19,34	STC-1	96,101	cholecystokinin	STC-1	25298(Tax:10116)	81801(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Peptones stimulate cholecystokinin secretion and gene transcription in the intestinal cell line STC-1 .
9492022	0	cholecystokinin	14,29	STC-1	86,91	cholecystokinin	STC-1	25298(Tax:10116)	81801(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|cells cells|compound|END_ENTITY	Regulation of cholecystokinin secretion by peptones and peptidomimetic antibiotics in STC-1 cells .
9782155	0	cholecystokinin	22,37	STC-1	141,146	cholecystokinin	STC-1	885	6781	Gene	Gene	secretion|compound|START_ENTITY secretion|dep|mechanism mechanism|nmod|END_ENTITY	Fatty_acids stimulate cholecystokinin secretion via an acyl chain length-specific , Ca2 + - dependent mechanism in the enteroendocrine cell line STC-1 .
11111008	0	cholecystokinin	40,55	amylin	85,91	cholecystokinin	amylin	25298(Tax:10116)	24476(Tax:10116)	Gene	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Attenuation of the anorectic effects of cholecystokinin and bombesin by the specific amylin antagonist AC 253 .
17634201	0	cholecystokinin	39,54	apolipoprotein_AIV	15,33	cholecystokinin	apolipoprotein AIV	25298(Tax:10116)	25080(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of apolipoprotein_AIV with cholecystokinin on the control of food intake .
22461023	0	cholecystokinin	39,54	apolipoprotein_AIV	73,91	cholecystokinin	apolipoprotein AIV	12424(Tax:10090)	11808(Tax:10090)	Gene	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|nmod|mice mice|amod|END_ENTITY	Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein_AIV knockout mice .
7977748	0	cholecystokinin	14,29	bombesin	43,51	cholecystokinin	bombesin	885	2922	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of cholecystokinin secretion by bombesin in STC-1 cells .
1608534	0	cholecystokinin	78,93	c-fos	98,103	cholecystokinin	c-fos	25298(Tax:10116)	314322(Tax:10116)	Gene	Gene	analogue|nmod|START_ENTITY onset|appos|analogue onset|nmod|expression expression|amod|END_ENTITY	Late onset and long-lasting suppressive effects of ceruletide , an analogue of cholecystokinin , on c-fos mRNA expression in the rat striatum .
2118525	0	cholecystokinin	67,82	c-fos	151,156	cholecystokinin	c-fos	25298(Tax:10116)	2353	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene essential|nmod|expression enhancer|amod|essential contains|nsubj|enhancer contains|xcomp|identical identical|nmod|element element|nmod|gene gene|amod|END_ENTITY	A transcriptional enhancer essential for the expression of the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene .
7682304	0	cholecystokinin	70,85	c-fos	33,38	cholecystokinin	c-fos	25298(Tax:10116)	314322(Tax:10116)	Gene	Gene	brain|nmod|START_ENTITY induction|nmod|brain induction|nmod|expression expression|amod|END_ENTITY	The induction and suppression of c-fos expression in the rat brain by cholecystokinin and its antagonist L364 ,718 .
7440712	0	cholecystokinin	10,25	cholecystokinin	49,64	cholecystokinin	cholecystokinin	609547(Tax:9615)	609547(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder .
7440712	0	cholecystokinin	49,64	cholecystokinin	10,25	cholecystokinin	cholecystokinin	609547(Tax:9615)	609547(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cholecystokinin and the octapeptide of cholecystokinin on the feline sphincter of Oddi and gallbladder .
15890776	0	cholecystokinin	39,54	ghrelin	26,33	cholecystokinin	ghrelin	25298(Tax:10116)	59301(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Peripheral interaction of ghrelin with cholecystokinin on feeding regulation .
17360909	0	cholecystokinin	106,121	ghrelin	141,148	cholecystokinin	ghrelin	25298(Tax:10116)	59301(Tax:10116)	Gene	Gene	and_amphetamine-regulated_transcript|nmod|START_ENTITY and_amphetamine-regulated_transcript|nmod|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript : stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin .
10991976	0	cholecystokinin	19,34	leptin	60,66	cholecystokinin	leptin	25298(Tax:10116)	25608(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Gastric effects of cholecystokinin and its interaction with leptin on brainstem neuronal activity in neonatal rats .
669076	0	cholecystokinin	38,53	motilin	11,18	cholecystokinin	motilin	609547(Tax:9615)	481748(Tax:9615)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of motilin and octapeptide of cholecystokinin on antral and duodenal myoelectric activity in the interdigestive state and during inhibition by secretin and gastric inhibitory polypeptide .
15297267	0	cholecystokinin	55,70	neurotrophin-4	74,88	cholecystokinin	neurotrophin-4	12424(Tax:10090)	78405(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice .
2390922	0	cholecystokinin	8,23	pancreatic_polypeptide	57,79	cholecystokinin	pancreatic polypeptide	609547(Tax:9615)	490944(Tax:9615)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|secretion secretion|amod|END_ENTITY	Role of cholecystokinin in bombesin - and meal-stimulated pancreatic_polypeptide secretion in dogs .
7846294	0	cholecystokinin	21,36	somatostatin	48,60	cholecystokinin	somatostatin	885	6750	Gene	Gene	START_ENTITY|acl|stimulated stimulated|dobj|secretion secretion|compound|END_ENTITY	Loxiglumide inhibits cholecystokinin stimulated somatostatin secretion and simultaneously enhances gastric_acid secretion in humans .
8185642	0	cholecystokinin-B_receptor	33,59	gastrin_receptor	65,81	cholecystokinin-B receptor	gastrin receptor	887	887	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of cloned human cholecystokinin-B_receptor as a gastrin_receptor .
16258365	0	cholecystokinin_1_receptor	52,78	CCK1R	80,85	cholecystokinin 1 receptor	CCK1R	886	886	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Advanced qRT-PCR technology allows detection of the cholecystokinin_1_receptor -LRB- CCK1R -RRB- expression in human pancreas .
22786615	0	cholecystokinin_2_receptor	18,44	CCK2R	46,51	cholecystokinin 2 receptor	CCK2R	887	887	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Promoting role of cholecystokinin_2_receptor -LRB- CCK2R -RRB- in gastrointestinal_stromal_tumour pathogenesis .
9332364	0	cholecystokinin_type-A_receptor	10,41	CCKAR	43,48	cholecystokinin type-A receptor	CCKAR	24889(Tax:10116)	24889(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disrupted cholecystokinin_type-A_receptor -LRB- CCKAR -RRB- gene in OLETF rats .
1358792	0	cholesterol_7_alpha-hydroxylase	21,52	CYP7	59,63	cholesterol 7 alpha-hydroxylase	CYP7	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the human cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- and localization to chromosome 8q11-q12 .
8020987	0	cholesterol_7_alpha-hydroxylase	48,79	CYP7	86,90	cholesterol 7 alpha-hydroxylase	CYP7	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and nucleotide sequences of the human cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- .
8105753	0	cholesterol_7_alpha-hydroxylase	57,88	CYP7	95,99	cholesterol 7 alpha-hydroxylase	CYP7	25428(Tax:10116)	25428(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic cloning , sequencing , and analysis of the hamster cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- .
8656080	0	cholesterol_7_alpha-hydroxylase	27,58	CYP7	65,69	cholesterol 7 alpha-hydroxylase	CYP7	25428(Tax:10116)	25428(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hormonal regulation of the cholesterol_7_alpha-hydroxylase gene -LRB- CYP7 -RRB- .
9521095	0	cholesterol_7_alpha-hydroxylase	15,46	CYP7	48,52	cholesterol 7 alpha-hydroxylase	CYP7	448985(Tax:9823)	448985(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alleles of the cholesterol_7_alpha-hydroxylase -LRB- CYP7 -RRB- gene in pigs selected for high or low plasma total cholesterol .
24582860	0	cholesterol_7_alpha-hydroxylase	35,66	Cyp7a1	68,74	cholesterol 7 alpha-hydroxylase	Cyp7a1	1581	1581	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Thyroid hormone induction of human cholesterol_7_alpha-hydroxylase -LRB- Cyp7a1 -RRB- in vitro .
2510717	0	cholesterol_7_alpha-hydroxylase	14,45	cytochrome_P-450	88,104	cholesterol 7 alpha-hydroxylase	cytochrome P-450	25428(Tax:10116)	25251(Tax:10116)	Gene	Gene	START_ENTITY|nmod|form form|nmod|END_ENTITY	Inhibition of cholesterol_7_alpha-hydroxylase by an antibody to a male-specific form of cytochrome_P-450 from subfamily P450IIC .
10627496	0	cholesterol_7alpha-hydroxylase	61,91	CYP7A1	98,104	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	HNF4 and COUP-TFII interact to modulate transcription of the cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- .
10744771	0	cholesterol_7alpha-hydroxylase	81,111	CYP7A1	118,124	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- and agonist inhibit cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- transcription .
11402042	0	cholesterol_7alpha-hydroxylase	91,121	CYP7A1	128,134	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The negative effects of bile_acids and tumor_necrosis_factor-alpha on the transcription of cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- converge to hepatic nuclear factor-4 : a novel mechanism of feedback regulation of bile_acid synthesis mediated by nuclear receptors .
11967256	0	cholesterol_7alpha-hydroxylase	49,79	CYP7A1	86,92	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dietary cholesterol fails to stimulate the human cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- in transgenic_mice .
12093894	0	cholesterol_7alpha-hydroxylase	6,36	CYP7A1	38,44	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Human cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- deficiency has a hypercholesterolemic phenotype .
14960721	0	cholesterol_7alpha-hydroxylase	28,58	CYP7A1	65,71	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The inhibition of the human cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome_proliferator-activated_receptor_alpha heterodimer .
15479137	0	cholesterol_7alpha-hydroxylase	31,61	CYP7A1	63,69	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The A-204C polymorphism in the cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- gene determines the cholesterolemia responsiveness to a high-fat diet .
15629111	0	cholesterol_7alpha-hydroxylase	32,62	CYP7A1	64,70	cholesterol 7alpha-hydroxylase	CYP7A1	414834(Tax:9031)	414834(Tax:9031)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Species-specific mechanisms for cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- regulation by drugs and bile_acids .
19537927	0	cholesterol_7alpha-hydroxylase	35,65	CYP7A1	67,73	cholesterol 7alpha-hydroxylase	CYP7A1	1581	1581	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regulation of diurnal variation of cholesterol_7alpha-hydroxylase -LRB- CYP7A1 -RRB- activity in healthy subjects .
16885156	0	cholesterol_7alpha-hydroxylase	22,52	Insulin	0,7	cholesterol 7alpha-hydroxylase	Insulin	1581	3630	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Insulin regulation of cholesterol_7alpha-hydroxylase expression in human hepatocytes : roles of forkhead_box_O1 and sterol regulatory element-binding protein 1c .
11179691	0	cholesterol_7alpha-hydroxylase	14,44	orphan_receptor	86,101	cholesterol 7alpha-hydroxylase	orphan receptor	25428(Tax:10116)	259241(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- transcription by the liver orphan_receptor -LRB- LXRalpha -RRB- .
17920062	0	cholesterol_7alpha-hydroxylase	88,118	transforming_growth_factor_beta1	16,48	cholesterol 7alpha-hydroxylase	transforming growth factor beta1	1581	7040	Gene	Gene	gene|amod|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	A novel role of transforming_growth_factor_beta1 in transcriptional repression of human cholesterol_7alpha-hydroxylase gene .
11887180	0	cholesterol_ester_transfer_protein	58,92	CETP	94,98	cholesterol ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the intron 1 splice donor site of the cholesterol_ester_transfer_protein -LRB- CETP -RRB- gene as a cause of hyperalphalipoproteinemia .
17196207	0	cholesterol_ester_transfer_protein	11,45	CETP	47,51	cholesterol ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of cholesterol_ester_transfer_protein -LRB- CETP -RRB- gene on adiposity in response to long-term overfeeding .
19728844	0	cholesterol_ester_transfer_protein	22,56	CETP	58,62	cholesterol ester transfer protein	CETP	1071	1071	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	TaqIB polymorphism in cholesterol_ester_transfer_protein -LRB- CETP -RRB- gene predicts future cardiovascular_death in patients experiencing an acute_coronary_syndrome .
22356288	0	cholesteryl_ester-transfer_protein	164,198	CETP	200,204	cholesteryl ester-transfer protein	CETP	1071	1071	Gene	Gene	discovery|nmod|START_ENTITY discovery|appos|END_ENTITY	On - and off-target pharmacology of torcetrapib : current understanding and implications for the structure activity relationships -LRB- SAR -RRB- , discovery and development of cholesteryl_ester-transfer_protein -LRB- CETP -RRB- inhibitors .
19417222	0	cholesteryl_ester_transfer_protein	50,84	Apolipoprotein_CI	0,17	cholesteryl ester transfer protein	Apolipoprotein CI	1071	341	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	Apolipoprotein_CI is a physiological regulator of cholesteryl_ester_transfer_protein activity in human plasma but not in rabbit plasma .
10831518	0	cholesteryl_ester_transfer_protein	15,49	CETP	51,55	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene to LDL particle size : use of a novel tetranucleotide repeat within the CETP promoter .
11029971	0	cholesteryl_ester_transfer_protein	63,97	CETP	99,103	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effect of postprandial lipaemia and Taq 1B polymorphism of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene on CETP mass , activity , associated lipoproteins and plasma lipids .
12070157	0	cholesteryl_ester_transfer_protein	92,126	CETP	137,141	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Apolipoprotein CI_deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl_ester_transfer_protein -LRB- CETP -RRB- in CETP transgenic/ApoCI-knocked out mice .
14998629	0	cholesteryl_ester_transfer_protein	4,38	CETP	40,44	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The cholesteryl_ester_transfer_protein -LRB- CETP -RRB- TaqIB polymorphism in the cholesterol and recurrent events study : no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome : a prospective analysis of the CETP TaqIB polymorphism on cardiovascular outcome and interaction with cholesterol-lowering therapy .
15228446	0	cholesteryl_ester_transfer_protein	14,48	CETP	50,54	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- in germinal centre B cells and their neoplastic counterparts .
16384616	0	cholesteryl_ester_transfer_protein	26,60	CETP	62,66	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	I405V polymorphism of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in young and very old people .
16829344	0	cholesteryl_ester_transfer_protein	17,51	CETP	53,57	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat .
19004846	0	cholesteryl_ester_transfer_protein	85,119	CETP	121,125	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Assessment of the CYP3A-mediated drug interaction potential of anacetrapib , a potent cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitor , in healthy volunteers .
19491422	0	cholesteryl_ester_transfer_protein	22,56	CETP	58,62	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Taq1B polymorphism of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in primary combined_hyperlipidaemia .
19843057	0	cholesteryl_ester_transfer_protein	75,109	CETP	111,115	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Single-dose pharmacokinetics and pharmacodynamics of anacetrapib , a potent cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitor , in healthy subjects .
20068209	0	cholesteryl_ester_transfer_protein	48,82	CETP	84,88	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a functional polymorphism in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene with memory decline and incidence of dementia .
22122993	0	cholesteryl_ester_transfer_protein	19,53	CETP	55,59	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in Japanese hyperalphalipoproteinemic subjects .
23658137	0	cholesteryl_ester_transfer_protein	10,44	CETP	46,50	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Future of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- inhibitors : a pharmacological perspective .
24176024	0	cholesteryl_ester_transfer_protein	26,60	CETP	62,66	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	TaqIB polymorphism in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men .
24659026	0	cholesteryl_ester_transfer_protein	9,43	CETP	45,49	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Elevated cholesteryl_ester_transfer_protein -LRB- CETP -RRB- activity , a major determinant of the atherogenic_dyslipidemia , and atherosclerotic_cardiovascular_disease in South Asians .
25366166	0	cholesteryl_ester_transfer_protein	15,49	CETP	51,55	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene polymorphism , high density lipoprotein cholesterol and risk of coronary_artery_disease : a meta-analysis using a Mendelian randomization approach .
2567644	0	cholesteryl_ester_transfer_protein	29,63	CETP	65,69	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	`` Variability gene '' effect of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- genes .
7910585	0	cholesteryl_ester_transfer_protein	25,59	CETP	61,65	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA polymorphisms of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene in Italian and Greek migrants to Australia .
8447724	0	cholesteryl_ester_transfer_protein	94,128	CETP	130,134	cholesteryl ester transfer protein	LCAT	1071	3931	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Decrease of plasma large , light LDL -LRB- LDL1 -RRB- , HDL2 and HDL3 levels with concomitant increase of cholesteryl_ester_transfer_protein -LRB- CETP -RRB- activity by probucol in type_II_hyperlipoproteinemia .
8830936	0	cholesteryl_ester_transfer_protein	56,90	CETP	92,96	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphic site in the 3 ' untranslated region of the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene is associated with low CETP activity .
9543093	0	cholesteryl_ester_transfer_protein	22,56	CETP	58,62	cholesteryl ester transfer protein	CETP	1071	1071	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	R451Q mutation in the cholesteryl_ester_transfer_protein -LRB- CETP -RRB- gene is associated with high plasma CETP activity .
9714785	0	cholesteryl_ester_transfer_protein	35,69	CETP	165,169	cholesteryl ester transfer protein	CETP	100758852	1071	Gene	Gene	probucol|nmod|START_ENTITY mRNA|amod|probucol Mechanism|nmod|mRNA Mechanism|nmod|line line|acl:relcl|transfected transfected|nmod|gene gene|compound|END_ENTITY	Mechanism of action of probucol on cholesteryl_ester_transfer_protein -LRB- CETP -RRB- mRNA in a Chinese_hamster ovary cell line that had been stably transfected with a human CETP gene .
8530390	0	cholesteryl_ester_transfer_protein	34,68	apolipoprotein_AI_regulatory_protein-1	113,151	cholesteryl ester transfer protein	apolipoprotein AI regulatory protein-1	1071	7026	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the cholesteryl_ester_transfer_protein gene by the orphan nuclear hormone receptor apolipoprotein_AI_regulatory_protein-1 .
18662427	0	cholesteryl_ester_transfer_protein	124,158	hepatic_lipase	160,174	cholesteryl ester transfer protein	hepatic lipase	1071	3990	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Human fasting plasma concentrations of vitamin_E and carotenoids , and their association with genetic variants in apo C-III , cholesteryl_ester_transfer_protein , hepatic_lipase , intestinal fatty_acid binding protein and microsomal triacylglycerol transfer protein .
8408618	0	cholesteryl_ester_transfer_protein	85,119	lipoprotein_apolipoproteins_A-I_and_A-II	35,75	cholesteryl ester transfer protein	lipoprotein apolipoproteins A-I and A-II	1071	114548	Gene	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	Delayed catabolism of high density lipoprotein_apolipoproteins_A-I_and_A-II in human cholesteryl_ester_transfer_protein deficiency .
18561487	0	choline_acetyltransferase	25,50	ChAc	52,56	choline acetyltransferase	ChAc	395314(Tax:9031)	395314(Tax:9031)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Developmental changes of choline_acetyltransferase -LRB- ChAc -RRB- activity in chick embryo spinal and sympathetic ganglia .
3313393	0	choline_acetyltransferase	19,44	Insulin	0,7	choline acetyltransferase	Insulin	395314(Tax:9031)	396145(Tax:9031)	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Insulin stimulates choline_acetyltransferase activity in cultured embryonic_chicken_retina_neurons .
2130652	0	choline_acetyltransferase	74,99	Nerve_growth_factor	0,19	choline acetyltransferase	Nerve growth factor	290567(Tax:10116)	310738(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY increase|nmod|activity induces|dobj|increase induces|nsubj|END_ENTITY	Nerve_growth_factor induces a dose-dependent and long-lasting increase of choline_acetyltransferase activity in the septal area and hippocampus of uninjured rats .
2771166	0	choline_acetyltransferase	52,77	basic_fibroblast_growth_factor	11,41	choline acetyltransferase	basic fibroblast growth factor	290567(Tax:10116)	54250(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY Effects|nmod|activity Effects|nmod|END_ENTITY	Effects of basic_fibroblast_growth_factor -LRB- bFGF -RRB- on choline_acetyltransferase activity and astroglial reaction in adult rats after partial fimbria transection .
1515953	0	choline_acetyltransferase	56,81	nerve_growth_factor	33,52	choline acetyltransferase	nerve growth factor	290567(Tax:10116)	310738(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effect of delayed treatment with nerve_growth_factor on choline_acetyltransferase activity in the cortex of rats with lesions of the nucleus basalis magnocellularis : dose requirements .
2790481	0	choline_acetyltransferase	33,58	nerve_growth_factor	87,106	choline acetyltransferase	nerve growth factor	12647(Tax:10090)	18049(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity END_ENTITY|nsubj|stimulation	Axotomy-dependent stimulation of choline_acetyltransferase activity by exogenous mouse nerve_growth_factor in adult rat basal forebrain .
8405259	0	choline_acetyltransferase	54,79	nerve_growth_factor	17,36	choline acetyltransferase	nerve growth factor	290567(Tax:10116)	310738(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY Reversibility|nmod|activity Reversibility|nmod|enhancement enhancement|nmod:poss|END_ENTITY	Reversibility of nerve_growth_factor 's enhancement of choline_acetyltransferase activity in cultured embryonic rat septum .
8592155	0	choline_acetyltransferase	61,86	nerve_growth_factor	24,43	choline acetyltransferase	nerve growth factor	290567(Tax:10116)	310738(Tax:10116)	Gene	Gene	transport|compound|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	Differential effects of nerve_growth_factor on expression of choline_acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture .
10986016	0	choline_acetyltransferase	59,84	tyrosine_hydroxylase	16,36	choline acetyltransferase	tyrosine hydroxylase	290567(Tax:10116)	25085(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of tyrosine_hydroxylase and downregulation of choline_acetyltransferase in lead-exposed PC12 cells : the role of PKC activation .
2573410	0	choline_acetyltransferase	110,135	tyrosine_hydroxylase	161,181	choline acetyltransferase	tyrosine hydroxylase	290567(Tax:10116)	25085(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY increase|nmod|activity increase|nmod|activity activity|amod|END_ENTITY	Cholinergic differentiation of clonal rat pheochromocytoma cells -LRB- PC12 -RRB- induced by retinoic_acid : increase of choline_acetyltransferase activity and decrease of tyrosine_hydroxylase activity .
25740612	0	choline_kinase_beta	29,48	CHKB	50,54	choline kinase beta	CHKB	1120	1120	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	New splicing mutation in the choline_kinase_beta -LRB- CHKB -RRB- gene causing a muscular_dystrophy detected by whole-exome sequencing .
24525247	0	choline_transporter	49,68	Ubiquitin_C-terminal_hydrolase_L1	0,33	choline transporter	Ubiquitin C-terminal hydrolase L1	60482	7345	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ubiquitin_C-terminal_hydrolase_L1 interacts with choline_transporter in cholinergic cells .
25511584	0	chondroitin-4-sulfotransferase	14,44	BMP4	107,111	chondroitin-4-sulfotransferase	BMP4	50515	652	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
25511584	0	chondroitin-4-sulfotransferase	14,44	CHST11	46,52	chondroitin-4-sulfotransferase	CHST11	50515	50515	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
25511584	0	chondroitin-4-sulfotransferase	14,44	arylsulfatase_B	88,103	chondroitin-4-sulfotransferase	arylsulfatase B	50515	411	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of chondroitin-4-sulfotransferase -LRB- CHST11 -RRB- expression by opposing effects of arylsulfatase_B on BMP4 and Wnt9A .
21123170	0	chondroitin_4-O-sulfotransferase-1	19,53	Wnt-3a	93,99	chondroitin 4-O-sulfotransferase-1	Wnt-3a	58250(Tax:10090)	22416(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY Down-regulation|nmod|signaling triggers|nsubj|Down-regulation triggers|dobj|diffusion diffusion|nmod|END_ENTITY	Down-regulation of chondroitin_4-O-sulfotransferase-1 by Wnt signaling triggers diffusion of Wnt-3a .
24716865	0	chondroitin_6-O-sulfotransferase_1	16,50	OASIS	0,5	chondroitin 6-O-sulfotransferase 1	OASIS	53374(Tax:10090)	26427(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	OASIS regulates chondroitin_6-O-sulfotransferase_1 gene transcription in the injured adult mouse cerebral cortex .
23811343	0	chondroitin_synthase-1	2,24	ChSy-1	26,32	chondroitin synthase-1	ChSy-1	22856	22856	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A chondroitin_synthase-1 -LRB- ChSy-1 -RRB- missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1 .
10446267	0	chordin	103,110	Bone_morphogenetic_protein_1	0,28	chordin	Bone morphogenetic protein 1	398045(Tax:8355)	399093(Tax:8355)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Bone_morphogenetic_protein_1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading chordin , a BMP4 antagonist .
18318733	0	chordin	124,131	Xwnt8	57,62	chordin	Xwnt8	398045(Tax:8355)	397970(Tax:8355)	Gene	Gene	causes|nmod|START_ENTITY causes|nsubj|END_ENTITY	VegT , eFGF and Xbra cause overall posteriorization while Xwnt8 causes eye-level restricted posteriorization in synergy with chordin in early Xenopus development .
18339208	0	chorionic_gonadotropin_beta_subunit	19,54	U1_snRNA	78,86	chorionic gonadotropin beta subunit	U1 snRNA	1082	26871	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduction of human chorionic_gonadotropin_beta_subunit expression by modified U1_snRNA caused apoptosis in cervical cancer cells .
12827496	0	choroideremia	31,44	CHM	47,50	choroideremia	CHM	1121	1121	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel types of mutation in the choroideremia -LRB- CHM -RRB- gene : a full-length L1 insertion and an intronic mutation activating a cryptic exon .
9678418	0	choroideremia	98,111	CHM	113,116	choroideremia	CHM	1121	1121	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Altered rep-1 expression due to substitution at position +3 of the IVS13 splice-donor site of the choroideremia -LRB- CHM -RRB- gene .
10447648	0	choroideremia	47,60	REP-1	0,5	choroideremia	REP-1	1121	1121	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	REP-1 gene mutations in Japanese patients with choroideremia .
8188272	0	choroideremia-like	15,33	CHML	35,39	choroideremia-like	CHML	1122	1122	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the choroideremia-like -LRB- CHML -RRB- gene at 1q42-qter and mutation analysis in patients with Usher_syndrome_type_II .
20865721	0	chromatin-remodeling_factor	39,66	ATRX	26,30	chromatin-remodeling factor	ATRX	192195(Tax:10090)	22589(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	Reduced expression of the ATRX gene , a chromatin-remodeling_factor , causes hippocampal_dysfunction in mice .
25057015	0	chromatin_assembly_factor-1	48,75	p150	26,30	chromatin assembly factor-1	p150	10036	10036	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	A separable domain of the p150 subunit of human chromatin_assembly_factor-1 promotes protein and chromosome associations with nucleoli .
16826239	0	chromatin_assembly_factor_1	81,108	p150	65,69	chromatin assembly factor 1	p150	10036	10036	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin_assembly_factor_1 with proliferating_cell_nuclear_antigen .
17573145	0	chromodomain_Y-like	61,80	CDYL	82,86	chromodomain Y-like	CDYL	9425	9425	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Functional consequences of new exon acquisition in mammalian chromodomain_Y-like -LRB- CDYL -RRB- genes .
22033927	0	chromodomain_helicase_DNA-binding_protein_1	25,68	Chd1	70,74	chromodomain helicase DNA-binding protein 1	Chd1	856911(Tax:4932)	856911(Tax:4932)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Crystal structure of the chromodomain_helicase_DNA-binding_protein_1 -LRB- Chd1 -RRB- DNA-binding domain in complex with DNA .
12687271	0	chromogranin_A	22,36	CD57	48,52	chromogranin A	CD57	1113	27087	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Different patterns of chromogranin_A and Leu-7 -LRB- CD57 -RRB- expression in gastrointestinal_carcinoids : immunohistochemical and confocal laser scanning microscopy study .
20806177	0	chromogranin_A	19,33	CgA	35,38	chromogranin A	CgA	1113	1113	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	The differences in chromogranin_A -LRB- CgA -RRB- concentrations measured in serum and in plasma by IRMA and ELISA methods .
25754282	0	chromogranin_A	14,28	CgA	30,33	chromogranin A	CgA	1113	1113	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Comparison of chromogranin_A -LRB- CgA -RRB- levels in serum and plasma -LRB- EDTA2K -RRB- and the respective reference ranges in healthy males .
3814131	0	chromogranin_A	19,33	CgA	35,38	chromogranin A	CgA	1113	1113	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for human chromogranin_A -LRB- CgA -RRB- is located on chromosome 14 .
17540723	0	chromogranin_A	15,29	Cox-2	0,5	chromogranin A	Cox-2	1113	5743	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Cox-2 promotes chromogranin_A expression and bioactivity : evidence for a prostaglandin_E2-dependent mechanism and the involvement of a proximal cyclic_adenosine_5 ' - monophosphate-responsive element .
18262756	0	chromogranin_A	28,42	Protein_kinase_D2	0,17	chromogranin A	Protein kinase D2	1113	25865	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Protein_kinase_D2 regulates chromogranin_A secretion in human BON_neuroendocrine_tumour cells .
3341449	0	chromogranin_A	16,30	chromogranin_B	52,66	chromogranin A	chromogranin B	1113	1114	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of chromogranin_A and secretogranin_I -LRB- chromogranin_B -RRB- in neuroendocrine cells and tumors .
24796622	0	chromogranin_A	17,31	gastrin	39,46	chromogranin A	gastrin	1113	2520	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	An evaluation of chromogranin_A versus gastrin and progastrin in gastrinoma diagnosis and control .
11288956	0	chromogranin_A	27,41	neuron-specific_enolase	114,137	chromogranin A	neuron-specific enolase	1113	2026	Gene	Gene	assay|nmod|START_ENTITY assay|dep|evaluation evaluation|nmod|END_ENTITY	Immunoradiometric assay of chromogranin_A in the diagnosis of small_cell_lung_cancer : comparative evaluation with neuron-specific_enolase .
17585539	0	chromogranin_A	18,32	neuron-specific_enolase	34,57	chromogranin A	neuron-specific enolase	1113	2026	Gene	Gene	product|compound|START_ENTITY product|dep|END_ENTITY	Selected markers -LRB- chromogranin_A , neuron-specific_enolase , synaptophysin , protein gene product 9.5 -RRB- in diagnosis and prognosis of neuroendocrine_pulmonary_tumours .
12297497	0	chromogranin_A	12,26	plasmin	48,55	chromogranin A	plasmin	1113	5340	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Cleavage of chromogranin_A N-terminal domain by plasmin provides a new mechanism for regulating cell adhesion .
3608978	0	chromogranin_A	81,95	secretogranin_I	31,46	chromogranin B	secretogranin I	1114	1114	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	The primary structure of human secretogranin_I -LRB- chromogranin_B -RRB- : comparison with chromogranin_A reveals homologous terminal domains and a large intervening variable region .
3947055	0	chromogranin_A	39,53	secretory_protein-I	70,89	chromogranin A	secretory protein-I	1113	1113	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Structural characterization of adrenal chromogranin_A and parathyroid secretory_protein-I as homologs .
17585539	0	chromogranin_A	18,32	synaptophysin	59,72	chromogranin A	synaptophysin	1113	6855	Gene	Gene	product|compound|START_ENTITY product|dep|END_ENTITY	Selected markers -LRB- chromogranin_A , neuron-specific_enolase , synaptophysin , protein gene product 9.5 -RRB- in diagnosis and prognosis of neuroendocrine_pulmonary_tumours .
3341449	0	chromogranin_B	52,66	chromogranin_A	16,30	chromogranin B	chromogranin A	1114	1113	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of chromogranin_A and secretogranin_I -LRB- chromogranin_B -RRB- in neuroendocrine cells and tumors .
10906121	0	chromogranin_B	15,29	chromogranin_B	64,78	chromogranin B	chromogranin B	281071(Tax:9913)	281071(Tax:9913)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of chromogranin_B and the near N-terminal region of chromogranin_B with an intraluminal loop peptide of the inositol_1 ,4 , _ 5-trisphosphate receptor .
10906121	0	chromogranin_B	64,78	chromogranin_B	15,29	chromogranin B	chromogranin B	281071(Tax:9913)	281071(Tax:9913)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of chromogranin_B and the near N-terminal region of chromogranin_B with an intraluminal loop peptide of the inositol_1 ,4 , _ 5-trisphosphate receptor .
2335203	0	chromogranin_B	30,44	secretogranin_I	46,61	chromogranin B	secretogranin I	12653(Tax:10090)	12653(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The organisation of the mouse chromogranin_B -LRB- secretogranin_I -RRB- gene .
16556729	0	chromogranin_a	25,39	Chga	41,45	chromogranin a	Chga	12652(Tax:10090)	12652(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Targeted ablation of the chromogranin_a -LRB- Chga -RRB- gene : normal neuroendocrine dense-core secretory granules and increased expression of other granins .
20729505	0	chromogranin_a	152,166	Chga	168,172	chromogranin a	Chga	12652(Tax:10090)	12652(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of reactive oxygen species in hyperadrenergic hypertension : biochemical , physiological , and pharmacological evidence from targeted ablation of the chromogranin_a -LRB- Chga -RRB- gene .
19215537	0	chromogranin_a	14,28	secretogranin_I	49,64	chromogranin a	secretogranin I	281070(Tax:9913)	281071(Tax:9913)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of chromogranin_a and chromogranin_B -LRB- secretogranin_I -RRB- synthesis in bovine cultured chromaffin cells .
15620717	0	chromogranins_A_and_B	87,108	syntaxin_1A	12,23	chromogranins A and B	syntaxin 1A	1113;1114	6804	Gene	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of syntaxin_1A in secretory granules of chromaffin cells and interaction with chromogranins_A_and_B .
15566486	0	chromosome_14_open_reading_frame_4	45,79	C14orf4	81,88	chromosome 14 open reading frame 4	C14orf4	64207	64207	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the bovine homologue of the human chromosome_14_open_reading_frame_4 -LRB- C14orf4 -RRB- gene to BTA10q36 .
24595136	0	chromosome_region_maintenance_1	29,60	CRM1	62,66	chromosome region maintenance 1	CRM1	103573(Tax:10090)	103573(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Antitumor effects of a novel chromosome_region_maintenance_1 -LRB- CRM1 -RRB- inhibitor on non-small_cell_lung_cancer cells in vitro and in mouse tumor xenografts .
25148895	0	chromosome_region_maintenance_1	15,46	CRM1	48,52	chromosome region maintenance 1	CRM1	7514	7514	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of chromosome_region_maintenance_1 -LRB- CRM1 -RRB- in the formation and progression of esophageal_squamous_cell_carcinoma .
10497389	0	chronic_obstructive_pulmonary_disease	26,63	COPD	65,69	chronic obstructive pulmonary disease	COPD	260431	260431	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Genetic risk factors for chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
18398787	0	chronic_obstructive_pulmonary_disease	99,136	COPD	138,142	chronic obstructive pulmonary disease	COPD	260431	260431	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Friend or foe : combination therapy with inhaled corticosteroids and long-acting beta2-agonists in chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
20662279	0	chronic_obstructive_pulmonary_disease	69,106	COPD	108,112	chronic obstructive pulmonary disease	COPD	260431	260431	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Preanesthetic evaluation , preparation and prognostic prediction for chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
22828230	0	chronic_obstructive_pulmonary_disease	113,150	COPD	152,156	chronic obstructive pulmonary disease	COPD	260431	260431	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- The role of the quality of hospital discharge records on the comparative evaluation of outcomes : the example of chronic_obstructive_pulmonary_disease -LRB- COPD -RRB- -RSB- .
16098962	0	chs-1	26,31	chitin_synthase	4,19	chs-1	chitin synthase	172508(Tax:6239)	173405(Tax:6239)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	The chitin_synthase genes chs-1 and chs-2 are essential for C. _ elegans development and responsible for chitin deposition in the eggshell and pharynx , respectively .
12815038	0	chymase	32,39	Albumin	0,7	chymase	Albumin	1215	213	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Albumin is a substrate of human chymase .
8468056	0	chymase	20,27	CMA1	34,38	chymase	CMA1	1215	1215	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human mast cell chymase gene -LRB- CMA1 -RRB- : mapping to the cathepsin_G / granzyme gene cluster and lineage-restricted expression .
9003378	0	chymase	75,82	Lactoferrin	0,11	chymase	Lactoferrin	29265(Tax:10116)	301034(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Lactoferrin regulates the activity of heparin proteoglycan-bound mast cell chymase : characterization of the binding of heparin to lactoferrin .
11502696	0	chymase	43,50	angiotensin_II	72,86	chymase	angiotensin II	1215	183	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Functional evidence for a role of vascular chymase in the production of angiotensin_II in isolated human arteries .
12151872	0	chymase	23,30	angiotensin_II	34,48	chymase	angiotensin II	1215	183	Gene	Gene	role|nmod|START_ENTITY Dissecting|dobj|role Dissecting|nmod|formation formation|amod|END_ENTITY	Dissecting the role of chymase in angiotensin_II formation and heart_and_blood_vessel_diseases .
15590479	0	chymase	196,203	angiotensin_II	43,57	chymase	angiotensin II	1215	183	Gene	Gene	involvement|nmod|START_ENTITY Measurement|dep|involvement Measurement|nmod|activities activities|nmod|systems systems|amod|END_ENTITY	Measurement of activities in two different angiotensin_II generating systems , chymase and angiotensin-converting_enzyme , in the vitreous fluid of vitreoretinal_diseases : a possible involvement of chymase in the pathogenesis of macular hole patients .
15590479	0	chymase	78,85	angiotensin_II	43,57	chymase	angiotensin II	1215	183	Gene	Gene	Measurement|amod|START_ENTITY Measurement|nmod|activities activities|nmod|systems systems|amod|END_ENTITY	Measurement of activities in two different angiotensin_II generating systems , chymase and angiotensin-converting_enzyme , in the vitreous fluid of vitreoretinal_diseases : a possible involvement of chymase in the pathogenesis of macular hole patients .
25787365	0	chymase	49,56	angiotensin_II	125,139	chymase	angiotensin II	1215	183	Gene	Gene	activation|amod|START_ENTITY activation|dep|mechanism mechanism|nmod|generation generation|amod|END_ENTITY	-LSB- 17-OR -RSB- : Histone deacetylase inhibition promotes chymase activation in endothelial cells : A potential mechanism of increased angiotensin_II generation in preeclampsia .
8293772	0	chymase	80,87	angiotensin_II	8,22	chymase	angiotensin II	1215	183	Gene	Gene	formation|dep|START_ENTITY formation|compound|END_ENTITY	Cardiac angiotensin_II formation : the angiotensin-I_converting_enzyme and human chymase .
9257695	0	chymase	13,20	angiotensin_II	32,46	chymase	angiotensin II	1215	183	Gene	Gene	START_ENTITY|acl:relcl|forms forms|dobj|END_ENTITY	Induction of chymase that forms angiotensin_II in the monkey atherosclerotic aorta .
9285934	0	chymase	49,56	angiotensin_II	31,45	chymase	angiotensin II	1215	183	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Conversion of angiotensin_I to angiotensin_II by chymase activity in human pulmonary membranes .
9821858	0	chymase	19,26	angiotensin_II	30,44	chymase	angiotensin II	1215	183	Gene	Gene	role|nmod|START_ENTITY role|nmod|formation formation|amod|END_ENTITY	Functional role of chymase in angiotensin_II formation in human vascular tissue .
15869764	0	chymase	71,78	angiotensin_ii	42,56	chymase	angiotensin ii	29265(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Angiotensin_converting_enzyme-independent angiotensin_ii production by chymase is up-regulated in the ischemic kidney in renovascular_hypertension .
21781173	0	chymase	17,24	chymase	53,60	chymase	chymase	1215	1215	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Increased plasma chymase concentration and mast cell chymase expression in venous neointimal lesions of patients with CKD and ESRD .
21781173	0	chymase	53,60	chymase	17,24	chymase	chymase	1215	1215	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Increased plasma chymase concentration and mast cell chymase expression in venous neointimal lesions of patients with CKD and ESRD .
20670150	0	chymase	44,51	chymotrypsin-like_protease	16,42	chymase	chymotrypsin-like protease	1215	1215	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Elevated plasma chymotrypsin-like_protease -LRB- chymase -RRB- activity in women with preeclampsia .
24560885	0	chymase	62,69	p27	29,32	chymase	p27	1215	10671	Gene	Gene	generated|nmod|START_ENTITY generated|nsubjpass|END_ENTITY	Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase .
20670150	0	chymotrypsin-like_protease	16,42	chymase	44,51	chymotrypsin-like protease	chymase	1215	1215	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Elevated plasma chymotrypsin-like_protease -LRB- chymase -RRB- activity in women with preeclampsia .
22580415	0	chymotrypsin_C	27,41	CTRC	43,47	chymotrypsin C	CTRC	11330	11330	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comprehensive screening of chymotrypsin_C -LRB- CTRC -RRB- gene in tropical_calcific_pancreatitis identifies novel variants .
10623441	0	ciliary_neurotrophic_factor	11,38	CNTF	40,44	ciliary neurotrophic factor	CNTF	25707(Tax:10116)	25707(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of ciliary_neurotrophic_factor -LRB- CNTF -RRB- on protein turnover in cultured muscle cells .
10860786	0	ciliary_neurotrophic_factor	34,61	CNTF	63,67	ciliary neurotrophic factor	CNTF	25707(Tax:10116)	25707(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Adenovirus-mediated expression of ciliary_neurotrophic_factor -LRB- CNTF -RRB- rescues axotomized rat retinal ganglion cells but does not support axonal regeneration in vivo .
11299332	0	ciliary_neurotrophic_factor	90,117	CNTF	119,123	ciliary neurotrophic factor	CNTF	12803(Tax:10090)	12803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of Ras extracellular-signal-regulated_kinase -LRB- ERK -RRB- mediated signaling promotes ciliary_neurotrophic_factor -LRB- CNTF -RRB- expression in Schwann cells .
8759781	0	ciliary_neurotrophic_factor	31,58	CNTF	60,64	ciliary neurotrophic factor	CNTF	1270	1270	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and expression of ciliary_neurotrophic_factor -LRB- CNTF -RRB- in postmortem sciatic nerve from patients with motor_neuron_disease and diabetic_neuropathy .
9202298	0	ciliary_neurotrophic_factor	37,64	CNTF	66,70	ciliary neurotrophic factor	CNTF	25707(Tax:10116)	25707(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Construction and characterization of ciliary_neurotrophic_factor -LRB- CNTF -RRB- antagonists : microenvironmental difference in the CNTF receptor between rat and chicken cells for recognizing the D1 cap region .
9247976	0	ciliary_neurotrophic_factor	22,49	CNTF	51,55	ciliary neurotrophic factor	CNTF	1270	1270	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Schizophrenia and the ciliary_neurotrophic_factor -LRB- CNTF -RRB- gene : no evidence for association .
9363597	0	ciliary_neurotrophic_factor	72,99	CNTF	101,105	ciliary neurotrophic factor	CNTF	12803(Tax:10090)	1270	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation , characterization and chromosomal localization of the porcine ciliary_neurotrophic_factor -LRB- CNTF -RRB- gene .
9628240	0	ciliary_neurotrophic_factor	33,60	CNTF	62,66	ciliary neurotrophic factor	CNTF	1270	1270	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Screening for variability in the ciliary_neurotrophic_factor -LRB- CNTF -RRB- gene : no evidence for association with human obesity .
23271288	0	ciliary_neurotrophic_factor	53,80	Fibroblast_growth_factor-2	0,26	ciliary neurotrophic factor	Fibroblast growth factor-2	1270	2247	Gene	Gene	effect|nmod|START_ENTITY counteracts|dobj|effect counteracts|nsubj|END_ENTITY	Fibroblast_growth_factor-2 counteracts the effect of ciliary_neurotrophic_factor on spontaneous differentiation in adult hippocampal progenitor cells .
9030587	0	ciliary_neurotrophic_factor	76,103	Hepatocyte_growth_factor	0,24	ciliary neurotrophic factor	Hepatocyte growth factor	25707(Tax:10116)	24446(Tax:10116)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Hepatocyte_growth_factor promotes motor neuron survival and synergizes with ciliary_neurotrophic_factor .
9285712	0	ciliary_neurotrophic_factor	60,87	SHP-2	33,38	ciliary neurotrophic factor	SHP-2	1270	5781	Gene	Gene	induction|compound|START_ENTITY regulates|dobj|induction regulates|nsubj|END_ENTITY	The protein tyrosine phosphatase SHP-2 negatively regulates ciliary_neurotrophic_factor induction of gene expression .
16684879	0	ciliary_neurotrophic_factor	16,43	Sox10	0,5	ciliary neurotrophic factor	Sox10	12803(Tax:10090)	20665(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sox10 regulates ciliary_neurotrophic_factor gene expression in Schwann cells .
12890930	0	ciliary_neurotrophic_factor	35,62	gp130	66,71	ciliary neurotrophic factor	gp130	1270	3572	Gene	Gene	START_ENTITY|appos|cytokine cytokine|amod|END_ENTITY	Peritoneal fluid concentrations of ciliary_neurotrophic_factor , a gp130 cytokine , in women with endometriosis .
16818888	0	ciliary_neurotrophic_factor	106,133	gp130	0,5	ciliary neurotrophic factor	gp130	12803(Tax:10090)	16195(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary_neurotrophic_factor .
10207005	1	ciliary_neurotrophic_factor	149,176	leukemia_inhibitory_factor	95,121	ciliary neurotrophic factor	leukemia inhibitory factor	1270	3976	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Transfer of the leukemia_inhibitory_factor receptor-binding site from ciliary_neurotrophic_factor to interleukin-6 .
8093234	0	ciliary_neurotrophic_factor	23,50	tyrosine_hydroxylase	73,93	ciliary neurotrophic factor	tyrosine hydroxylase	25707(Tax:10116)	25085(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Cooperative effects of ciliary_neurotrophic_factor and norepinephrine on tyrosine_hydroxylase expression in cultured rat locus coeruleus neurons .
10491082	1	cingulin	117,125	CK2	92,95	cingulin	CK2	398149(Tax:8355)	399320(Tax:8355)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Identification of in vitro phosphorylation sites by protein kinase CK2 and association with cingulin .
23409073	0	cingulin	24,32	GATA-4	114,120	cingulin	GATA-4	483198(Tax:9615)	486079(Tax:9615)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|nmod|END_ENTITY	The junctional proteins cingulin and paracingulin modulate the expression of tight junction protein genes through GATA-4 .
24807907	0	cingulin	25,33	MgcRacGAP	0,9	cingulin	MgcRacGAP	57530	29127	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly .
10491389	0	cip1	18,22	p21	14,17	cip1	p21	1026	1026	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of p21 -LRB- cip1 -RRB- expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase .
10825236	0	cip1	4,8	p21	0,3	cip1	p21	1026	1026	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	p21 -LRB- cip1 -RRB- mRNA is controlled by endogenous transforming_growth_factor-beta1 in quiescent human hematopoietic stem/progenitor cells .
2510528	0	circulating_anodic_antigen	28,54	CAA	56,59	circulating anodic antigen	CAA	10194	10194	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of the schistosome circulating_anodic_antigen -LRB- CAA -RRB- in urine of patients with Schistosoma_mansoni or S. _ haematobium infections .
23046908	0	cirp	118,122	cold-inducible_RNA-binding_protein	82,116	cirp	cold-inducible RNA-binding protein	1153	1153	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible_RNA-binding_protein -LRB- cirp -RRB- expression in mammalian cells .
1399705	0	citrate_synthase	20,36	CS	38,40	citrate synthase	CS	397519(Tax:9823)	397519(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the citrate_synthase -LRB- CS -RRB- gene to the p12-p13 bands of chromosome 5 in pigs by in situ hybridization .
598842	0	citrate_synthase	21,37	CS	39,41	citrate synthase	CS	1431	1431	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Direct assignment of citrate_synthase -LRB- CS -RRB- gene to human chromosome 12 in man-mouse somatic cell hybrids .
19908284	0	citrin	14,20	SLC25A13	22,30	citrin	SLC25A13	50799(Tax:10090)	50799(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Low levels of citrin -LRB- SLC25A13 -RRB- expression in adult mouse brain restricted to neuronal_clusters .
15912112	0	clara_cell_secretory_protein	26,54	CC16	56,60	clara cell secretory protein	CC16	7356	7356	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Decreased serum levels of clara_cell_secretory_protein -LRB- CC16 -RRB- are associated with bronchiolitis_obliterans and may permit early diagnosis in patients after allogeneic stem-cell_transplantation .
12169693	0	clasp	30,35	Clk4	76,80	clasp	Clk4	53609(Tax:10090)	12750(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk .
12963733	0	claspin	15,22	Chk1	87,91	claspin	Chk1	398192(Tax:8355)	398191(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|site site|nmod|domain domain|nmod|END_ENTITY	Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation .
16123041	0	claspin	12,19	Chk1	63,67	claspin	Chk1	63967	1111	Gene	Gene	Cleavage|nmod|START_ENTITY inhibits|nsubj|Cleavage inhibits|dobj|pathway pathway|amod|END_ENTITY	Cleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathway .
16501606	0	claspin	29,36	Chk1	0,4	claspin	Chk1	63967	1111	Gene	Gene	stability|compound|START_ENTITY maintain|dobj|stability required|xcomp|maintain required|nsubjpass|END_ENTITY	Chk1 is required to maintain claspin stability .
2453562	0	class_I	32,39	H-2	40,43	class I	H-2	11980(Tax:10090)	111364(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY END_ENTITY|nsubj|analysis	Molecular analysis of deficient class_I H-2 antigen expression by mouse lung_carcinoma cells .
3274051	0	class_I	13,20	H-2	21,24	class I	H-2	11980(Tax:10090)	111364(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Influence of class_I H-2 gene expression on local tumor growth .
3461476	0	class_I	75,82	H-2Kb	89,94	class I	H-2Kb	11980(Tax:10090)	14972(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Alternative protein products with different carboxyl termini from a single class_I gene , H-2Kb .
9300699	0	class_II-associated_Ii_peptide	34,64	CLIP	66,70	class II-associated Ii peptide	CLIP	6249	6249	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Identification of residues in the class_II-associated_Ii_peptide -LRB- CLIP -RRB- region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner .
10837403	0	class_II-associated_invariant_chain_peptide	23,66	CLIP	68,72	class II-associated invariant chain peptide	CLIP	6249	6249	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The functional role of class_II-associated_invariant_chain_peptide -LRB- CLIP -RRB- in its ability to variably modulate immune responses .
18178340	0	class_III_beta-tubulin	16,38	HIF-1alpha	58,68	class III beta-tubulin	HIF-1alpha	10381	3091	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Hypoxia induces class_III_beta-tubulin gene expression by HIF-1alpha binding to its 3 ' flanking region .
23028798	0	class_III_beta_tubulin	18,40	HER2	55,59	class III beta tubulin	HER2	10381	2064	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Overexpression of class_III_beta_tubulin and amplified HER2 gene predict good response to paclitaxel and trastuzumab therapy .
12391222	0	class_II_trans-activator	38,62	CIITA	64,69	class II trans-activator	CIITA	4261	4261	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of the MHC class_II_trans-activator -LRB- CIITA -RRB- promoter III : identification of a novel regulatory region in the 5 ' - untranslated region and an important role for cAMP-responsive_element_binding_protein_1 and activating_transcription_factor-1 in CIITA-promoter III transcriptional activation in B lymphocytes .
11514596	0	class_II_transactivator	83,106	CIITA	108,113	class II transactivator	CIITA	4261	4261	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class_II_transactivator -LRB- CIITA -RRB- expression .
12102254	0	class_II_transactivator	16,39	CIITA	41,46	class II transactivator	CIITA	12265(Tax:10090)	12265(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the class_II_transactivator -LRB- CIITA -RRB- in MHC class I and II regulation and graft rejection in kidney .
12493643	0	class_II_transactivator	63,86	CIITA	88,93	class II transactivator	CIITA	4261	4261	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	The IRF-2 DNA binding domain facilitates the activation of the class_II_transactivator -LRB- CIITA -RRB- type IV promoter by IRF-1 .
14757364	0	class_II_transactivator	18,41	CIITA	43,48	class II transactivator	CIITA	12265(Tax:10090)	12265(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Downregulation of class_II_transactivator -LRB- CIITA -RRB- expression by synthetic cannabinoid CP55 ,940 .
15467734	0	class_II_transactivator	27,50	CIITA	52,57	class II transactivator	CIITA	4261	4261	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Epigenetic inactivation of class_II_transactivator -LRB- CIITA -RRB- is associated with the absence of interferon-gamma-induced HLA-DR expression in colorectal_and_gastric_cancer cells .
23524893	0	class_II_transactivator	84,107	CIITA	109,114	class II transactivator	CIITA	85483(Tax:10116)	85483(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Downregulating immunogenicity of Schwann cells via inhibiting a potential target of class_II_transactivator -LRB- CIITA -RRB- gene .
22051697	0	class_I_MHC-restricted_T_cell-associated_molecule	38,87	CRTAM	94,99	class I MHC-restricted T cell-associated molecule	CRTAM	56253	56253	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genome-wide association study reveals class_I_MHC-restricted_T_cell-associated_molecule gene -LRB- CRTAM -RRB- variants interact with vitamin_D levels to affect asthma exacerbations .
20480461	0	classification_and_regression_trees	78,113	CART	115,119	classification and regression trees	CART	9607	9607	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Pain-specific diagnosis patterns in claims data - Identification by means of classification_and_regression_trees -LRB- CART -RRB- -RSB- .
20111007	0	clathrin_heavy_chain	17,37	Bicaudal-D	0,10	clathrin heavy chain	Bicaudal-D	32537(Tax:7227)	35051(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Bicaudal-D binds clathrin_heavy_chain to promote its transport and augments synaptic vesicle recycling .
11485898	0	clathrin_heavy_chain	30,50	CLTC	57,61	clathrin heavy chain	CLTC	1213	1213	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fusion of the ALK gene to the clathrin_heavy_chain gene , CLTC , in inflammatory_myofibroblastic_tumor .
12920229	0	clathrin_heavy_chain	94,114	CLTC	121,125	clathrin heavy chain	CLTC	1213	1213	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	ALK + , CD30 - , CD20 - large B-cell_lymphoma containing anaplastic_lymphoma kinase -LRB- ALK -RRB- fused to clathrin_heavy_chain gene -LRB- CLTC -RRB- .
23861900	0	clathrin_heavy_chain	25,45	Sorting_nexin_9	0,15	clathrin heavy chain	Sorting nexin 9	1213	51429	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Sorting_nexin_9 recruits clathrin_heavy_chain to the mitotic spindle for chromosome alignment and segregation .
21152103	0	clathrin_light_chain_A	62,84	MAD2B	37,42	clathrin light chain A	MAD2B	1211	10459	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The mitotic_arrest_deficient protein MAD2B interacts with the clathrin_light_chain_A during mitosis .
18855015	0	claudin-1	39,48	IGF-I	0,5	claudin-1	IGF-I	12737(Tax:10090)	16000(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway .
12943524	0	claudin-1	32,41	Interferon-gamma	0,16	claudin-1	Interferon-gamma	9076	3458	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	Interferon-gamma down-regulates claudin-1 and impairs the epithelial barrier function in primary cultured human thyrocytes .
24265314	0	claudin-1	108,117	Protein_kinase_D	0,16	claudin-1	Protein kinase D	9076	5587	Gene	Gene	down-regulation|nmod|START_ENTITY promotes|nmod|down-regulation promotes|nsubj|END_ENTITY	Protein_kinase_D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1 .
25063840	0	claudin-1	108,117	Protein_kinase_D	0,16	claudin-1	Protein kinase D	9076	5587	Gene	Gene	down-regulation|nmod|START_ENTITY promotes|nmod|down-regulation promotes|nsubj|END_ENTITY	Protein_kinase_D promotes airway epithelial barrier dysfunction and permeability through down-regulation of claudin-1 .
17308096	0	claudin-1	16,25	Smad4	0,5	claudin-1	Smad4	9076	4089	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Smad4 regulates claudin-1 expression in a transforming_growth_factor-beta-independent manner in colon_cancer cells .
17551748	0	claudin-16	61,71	paracellin-1	47,59	claudin-16	paracellin-1	10686	10686	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Identification and subcellular localization of paracellin-1 -LRB- claudin-16 -RRB- in human salivary glands .
16723500	0	claudin-2	19,28	Cingulin	0,8	claudin-2	Cingulin	403649(Tax:9615)	483198(Tax:9615)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA .
21771795	0	claudin-2	31,40	Interleukin-6	0,13	claudin-2	Interleukin-6	9075	3569	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- regulates claudin-2 expression and tight junction permeability in intestinal epithelium .
24662742	0	claudin-2	119,128	Interleukin-6	0,13	claudin-2	Interleukin-6	12738(Tax:10090)	16193(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY activation|nmod|gene mediated|nmod|activation mediated|nsubjpass|modulation modulation|amod|END_ENTITY	Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene .
16723500	0	claudin-2	19,28	RhoA	88,92	claudin-2	RhoA	403649(Tax:9615)	403954(Tax:9615)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA .
19214581	0	claudin-2	22,31	TNFalpha	0,8	claudin-2	TNFalpha	9075	7124	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	TNFalpha up-regulates claudin-2 expression in epithelial HT-29 / B6 cells via phosphatidylinositol-3-kinase signaling .
25948735	0	claudin-2	53,62	Tumor_necrosis_factor-a	0,23	claudin-2	Tumor necrosis factor-a	733684(Tax:9823)	397086(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY induces|nmod|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-a induces a biphasic change in claudin-2 expression in tubular epithelial cells : role in barrier functions .
21102412	0	claudin-4	14,23	CLDN4	25,30	claudin-4	CLDN4	1364	1364	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of claudin-4 -LRB- CLDN4 -RRB- mRNA in intraductal_papillary_mucinous_neoplasms of the pancreas .
24280217	0	claudin-5	56,65	FoxO1	88,93	claudin-5	FoxO1	7122	2308	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Interleukin-4 induces up-regulation of endothelial cell claudin-5 through activation of FoxO1 : role in protection from complement-mediated injury .
23850770	0	claudin-5	123,132	TLR4	74,78	claudin-5	TLR4	65131(Tax:10116)	29260(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Neuroprotective effect of bicyclol in rat ischemic_stroke : down-regulates TLR4 , TLR9 , TRAF6 , NF-kB , MMP-9 and up-regulates claudin-5 expression .
24846172	0	claudin-5	54,63	estrogen_receptor_alpha	76,99	claudin-5	estrogen receptor alpha	12741(Tax:10090)	13982(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Mechanisms of transcriptional activation of the mouse claudin-5 promoter by estrogen_receptor_alpha and beta .
24970044	0	claudin-6	64,73	TTF-1	77,82	claudin-6	TTF-1	54419(Tax:10090)	22130(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1 , Gata-6 , and FoxA2 .
16054130	0	claudin-7	89,98	EpCAM	32,37	claudin-7	EpCAM	65132(Tax:10116)	171577(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7 .
18519685	0	claudin-7	10,19	Tcf-4	34,39	claudin-7	Tcf-4	1366	6925	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Defective claudin-7 regulation by Tcf-4 and Sox-9 disrupts the polarity and increases the tumorigenicity of colorectal_cancer cells .
24535143	0	claudin_1	18,27	b-catenin	44,53	claudin 1	b-catenin	9076	1499	Gene	Gene	expression|nmod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	The expression of claudin_1 correlates with b-catenin and is a prognostic factor of poor outcome in gastric_cancer .
18816383	0	claudin_16	113,123	CLDN16	125,131	claudin 16	CLDN16	10686	10686	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Familial_hypomagnesaemia with hypercalciuria and nephrocalcinosis -LRB- FHHNC -RRB- : compound heterozygous mutation in the claudin_16 -LRB- CLDN16 -RRB- gene .
18954444	0	claudin_4	94,103	matrix_metalloproteinase_9	126,152	claudin 4	matrix metalloproteinase 9	1364	4318	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Serial analysis of gene expression of lobular_carcinoma_in_situ identifies down regulation of claudin_4 and overexpression of matrix_metalloproteinase_9 .
22235125	0	claudin_5	100,109	CLDN5	111,116	claudin 5	CLDN5	7122	7122	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	ETS-related_gene -LRB- ERG -RRB- controls endothelial cell permeability via transcriptional regulation of the claudin_5 -LRB- CLDN5 -RRB- gene .
12738229	0	clock	46,51	BMAL1	91,96	clock	BMAL1	9575	406	Gene	Gene	components|compound|START_ENTITY promoter|nmod|components Regulation|nmod|promoter Regulation|dep|activation activation|nmod|END_ENTITY	Regulation of the PAI-1 promoter by circadian clock components : differential activation by BMAL1 and BMAL2 .
15523558	0	clock	59,64	BMAL1	0,5	clock	BMAL1	9575	406	Gene	Gene	components|nmod|START_ENTITY END_ENTITY|appos|components	BMAL1 and CLOCK , two essential components of the circadian clock , are involved in glucose homeostasis .
16109848	0	clock	10,15	BMAL1	42,47	clock	BMAL1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	control|nsubj|START_ENTITY control|nmod|SUMOylation SUMOylation|nmod|END_ENTITY	Circadian clock control by SUMOylation of BMAL1 .
16847346	0	clock	103,108	BMAL1	61,66	clock	BMAL1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	componentof|dep|START_ENTITY END_ENTITY|appos|componentof	Early aging and age-related pathologies in mice deficient in BMAL1 , the core componentof the circadian clock .
18430226	0	clock	25,30	BMAL1	58,63	clock	BMAL1	9575	406	Gene	Gene	PER2|compound|START_ENTITY Interaction|nmod|PER2 Interaction|nmod|END_ENTITY	Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK .
22249125	0	clock	136,141	BMAL1	151,156	clock	BMAL1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein , BMAL1 .
22249125	0	clock	37,42	BMAL1	151,156	clock	BMAL1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	modulator|nmod|START_ENTITY modulator|acl:relcl|protects protects|nmod|toxicity toxicity|nmod|drug drug|nmod|upregulation upregulation|nmod|protein protein|appos|END_ENTITY	Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein , BMAL1 .
25228643	0	clock	109,114	BMAL1	20,25	clock	BMAL1	9575	406	Gene	Gene	mediated|nmod|START_ENTITY inhibition|acl|mediated inhibition|nummod|END_ENTITY	Dual modes of CLOCK : BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock .
25961797	0	clock	39,44	BMAL1	83,88	clock	BMAL1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|interactions interactions|nmod|terminus terminus|compound|END_ENTITY	Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus .
9735336	0	clock	57,62	BMAL1	25,30	clock	BMAL1	9575	406	Gene	Gene	Clock|compound|START_ENTITY partner|nmod|Clock oscillation|appos|partner oscillation|nmod|END_ENTITY	Circadian oscillation of BMAL1 , a partner of a mammalian clock gene Clock , in rat suprachiasmatic nucleus .
9875535	0	clock	86,91	BMAL1	45,50	clock	BMAL1	9575	406	Gene	Gene	Clock|compound|START_ENTITY partner|nmod|Clock rhythm|appos|partner rhythm|nmod|expression expression|compound|END_ENTITY	Circadian rhythm and light responsiveness of BMAL1 expression , a partner of mammalian clock gene Clock , in the suprachiasmatic nucleus of rats .
21030946	0	clock	10,15	Bmal1	21,26	clock	Bmal1	12753(Tax:10090)	11865(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY deficiency|compound|END_ENTITY	Impact of clock gene Bmal1 deficiency on nutritionally induced obesity in mice .
22700438	0	clock	10,15	Bmal1	22,27	clock	Bmal1	373991(Tax:9031)	374115(Tax:9031)	Gene	Gene	genes|compound|START_ENTITY END_ENTITY|nsubj|genes	Circadian clock genes Bmal1 and Clock during early chick development .
19224106	0	clock	21,26	CLOCK	33,38	clock	CLOCK	9575	9575	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association study of clock gene -LRB- CLOCK -RRB- and schizophrenia and mood_disorders in the Japanese population .
10531061	0	clock	67,72	CRY1	26,30	clock	CRY1	9575	1407	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Light-independent role of CRY1 and CRY2 in the mammalian circadian clock .
19020302	0	clock	167,172	Cry1	100,104	clock	Cry1	12753(Tax:10090)	12952(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY process|nmod|regulation involved|nmod|process involved|nsubjpass|analyses analyses|nmod|genes genes|dep|END_ENTITY	Expression and functional analyses of circadian genes in mouse oocytes and preimplantation embryos : Cry1 is involved in the meiotic process independently of circadian clock regulation .
16717091	0	clock	68,73	EZH2	27,31	clock	EZH2	9575	2146	Gene	Gene	function|compound|START_ENTITY required|nmod|function required|nsubjpass|END_ENTITY	The polycomb group protein EZH2 is required for mammalian circadian clock function .
17364588	0	clock	64,69	Per1	76,80	clock	Per1	9575	5187	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Treatment with beta2-adrenoceptor agonist in vivo induces human clock gene , Per1 , mRNA expression in peripheral blood .
19570032	0	clock	28,33	Period2	39,46	clock	Period2	12753(Tax:10090)	18627(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of the circadian clock gene Period2 in the hippocampus : possible implications for synaptic plasticity and learned behaviour .
18662537	0	clock	42,47	SIRT1	0,5	clock	SIRT1	9575	23411	Gene	Gene	components|compound|START_ENTITY deacetylase|nmod|components deacetylase|nsubj|END_ENTITY	SIRT1 is a circadian deacetylase for core clock components .
18662546	0	clock	26,31	SIRT1	0,5	clock	SIRT1	9575	23411	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SIRT1 regulates circadian clock gene expression through PER2 deacetylation .
22879814	0	clock	68,73	TIMELESS	18,26	clock	TIMELESS	38872(Tax:7227)	33571(Tax:7227)	Gene	Gene	oscillations|nmod|START_ENTITY END_ENTITY|dobj|oscillations	CULLIN-3 controls TIMELESS oscillations in the Drosophila circadian clock .
23469106	0	clock	12,17	angiopoietin-like_protein_2	28,55	clock	angiopoietin-like protein 2	9575	23452	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	A molecular clock regulates angiopoietin-like_protein_2 expression .
24378737	0	clock	77,82	glucocorticoid_receptor	14,37	clock	glucocorticoid receptor	9575	2908	Gene	Gene	proteins|compound|START_ENTITY Modulation|nmod|proteins Modulation|nmod|properties properties|compound|END_ENTITY	Modulation of glucocorticoid_receptor induction properties by core circadian clock proteins .
11395012	0	clock	71,76	mPer1	26,31	clock	mPer1	12753(Tax:10090)	18626(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Differential functions of mPer1 , mPer2 , and mPer3 in the SCN circadian clock .
11606459	0	clock	54,59	mPer1	65,70	clock	mPer1	12753(Tax:10090)	18626(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse .
11475423	0	clock	43,48	mPer2	27,32	clock	mPer2	12753(Tax:10090)	18627(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Impaired expression of the mPer2 circadian clock gene in the suprachiasmatic nuclei of aging mice .
23785138	0	clock	31,36	p75_neurotrophin_receptor	0,25	clock	p75 neurotrophin receptor	12753(Tax:10090)	18053(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	p75_neurotrophin_receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks .
26403971	0	clock	51,56	period_2	62,70	clock	period 2	12753(Tax:10090)	18627(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Mitomycin_C modulates the circadian oscillation of clock gene period_2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts .
17431006	0	clock	10,15	steroidogenic_acute_regulatory_protein	35,73	clock	steroidogenic acute regulatory protein	373991(Tax:9031)	395421(Tax:9031)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Circadian clock gene regulation of steroidogenic_acute_regulatory_protein gene expression in preovulatory ovarian follicles .
9504927	0	clock	40,45	tim	35,38	clock	tim	38872(Tax:7227)	33571(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Conserved regions of the timeless -LRB- tim -RRB- clock gene in Drosophila analyzed through phylogenetic and functional studies .
21359199	0	clock	27,32	timeless	41,49	clock	timeless	9575	8914	Gene	Gene	protein|compound|START_ENTITY role|nmod|protein END_ENTITY|nsubj|role	An unexpected role for the clock protein timeless in developmental apoptosis .
9504927	0	clock	40,45	timeless	25,33	clock	timeless	38872(Tax:7227)	33571(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Conserved regions of the timeless -LRB- tim -RRB- clock gene in Drosophila analyzed through phylogenetic and functional studies .
17577058	0	clpX	20,24	ClpX	106,110	clpX	ClpX	10845	10845	Gene	Gene	gene|compound|START_ENTITY Distribution|nmod|gene Distribution|nmod|END_ENTITY	Distribution of the clpX gene in Brachyspira species and reactivity of recombinant Brachyspira_pilosicoli ClpX with sera from mice and humans .
17440807	0	cluster_of_differentiation_14	65,94	CD14	96,100	cluster of differentiation 14	CD14	929	929	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , mapping , and tissue expression of the porcine cluster_of_differentiation_14 -LRB- CD14 -RRB- gene .
17658775	0	cluster_of_differentiation_2	88,116	CD2	118,121	cluster of differentiation 2	CD2	914	914	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structure-based rational design of beta-hairpin peptides from discontinuous epitopes of cluster_of_differentiation_2 -LRB- CD2 -RRB- protein to modulate cell adhesion interaction .
24366867	0	cluster_of_differentiation_36	94,123	CD36	125,129	cluster of differentiation 36	CD36	12491(Tax:10090)	12491(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Endoplasmic reticulum stress promotes macrophage-derived foam cell formation by up-regulating cluster_of_differentiation_36 -LRB- CD36 -RRB- expression .
25076422	0	clusterin	7,16	ApoJ	18,22	clusterin	ApoJ	1191	1191	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Plasma clusterin -LRB- ApoJ -RRB- levels are associated with adiposity and systemic_inflammation .
22138303	0	clusterin	6,15	Apo_J	0,5	clusterin	Apo J	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Apo_J / clusterin expression and secretion : evidence for 15-deoxy - -LRB- 12,14 -RRB- - PGJ -LRB- 2 -RRB- - dependent mechanism .
21567405	0	clusterin	14,23	Bcl-XL	63,69	clusterin	Bcl-XL	1191	598	Gene	Gene	mediates|compound|START_ENTITY apoptosis|nsubj|mediates apoptosis|advcl|interacting interacting|nmod|END_ENTITY	Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain .
18075502	0	clusterin	55,64	Bcl-xL	34,40	clusterin	Bcl-xL	12759(Tax:10090)	12048(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis .
19879421	0	clusterin	12,21	CLU	23,26	clusterin	CLU	1191	1191	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of clusterin -LRB- CLU -RRB- in malignant transformation and drug resistance in breast_carcinomas .
21995960	0	clusterin	53,62	Gastrin	0,7	clusterin	Gastrin	24854(Tax:10116)	25320(Tax:10116)	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats .
26469759	0	clusterin	19,28	HMGB1	0,5	clusterin	HMGB1	1191	3146	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	HMGB1 induction of clusterin creates a chemoresistant niche in human prostate_tumor cells .
24599003	0	clusterin	55,64	Hypoxia_inducible_factor-1a	0,27	clusterin	Hypoxia inducible factor-1a	1191	3091	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Hypoxia_inducible_factor-1a directly regulates nuclear clusterin transcription by interacting with hypoxia response elements in the clusterin promoter .
21732348	0	clusterin	57,66	IL-24	6,11	clusterin	IL-24	1191	11009	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	mda-7 / IL-24 differentially regulates soluble and nuclear clusterin in prostate_cancer .
11054633	0	clusterin	20,29	SGP-2	31,36	clusterin	SGP-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Increased levels of clusterin -LRB- SGP-2 -RRB- mRNA and protein accompany rat ventral prostate involution following finasteride treatment .
21549685	0	clusterin	46,55	SREBP-1c	0,8	clusterin	SREBP-1c	1191	6720	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SREBP-1c regulates glucose-stimulated hepatic clusterin expression .
22166956	0	clusterin	15,24	TNF-a	28,33	clusterin	TNF-a	1191	7124	Gene	Gene	START_ENTITY|nmod|response response|amod|END_ENTITY	Implication of clusterin in TNF-a response of rheumatoid_synovitis : lesson from in vitro knock-down of clusterin in human synovial fibroblast cells .
7680346	0	clusterin	55,64	TRPM-2	47,53	clusterin	TRPM-2	24854(Tax:10116)	294329(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization and expression of the rat TRPM-2 -LRB- clusterin -RRB- gene , a gene implicated in apoptosis .
9010356	0	clusterin	108,117	TRPM-2	100,106	clusterin	TRPM-2	12759(Tax:10090)	28240(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effects of intermittent androgen suppression on the stem cell composition and the expression of the TRPM-2 -LRB- clusterin -RRB- gene in the Shionogi_carcinoma .
10406964	0	clusterin	42,51	Transforming_growth_factor_beta	0,31	clusterin	Transforming growth factor beta	1191	7040	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor_beta regulates clusterin gene expression via modulation of transcription factor c-Fos .
11281639	0	clusterin	96,105	apolipoprotein_J	78,94	clusterin	apolipoprotein J	1191	1191	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Apoptotic cell debris and phosphatidylserine-containing lipid vesicles induce apolipoprotein_J -LRB- clusterin -RRB- gene expression in vital fibroblasts .
9037392	0	clusterin	83,92	sulfated_glycoprotein-2	58,81	clusterin	sulfated glycoprotein-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The effect of estradiol-induced hypothalamic pathology on sulfated_glycoprotein-2 -LRB- clusterin -RRB- expression in the hypothalamus .
9713325	0	clusterin	24,33	sulfated_glycoprotein-2	35,58	clusterin	sulfated glycoprotein-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Transient expression of clusterin -LRB- sulfated_glycoprotein-2 -RRB- during development of rat pancreas .
11110696	0	cno	27,30	cappuccino	15,25	cno	cappuccino	117197(Tax:10090)	117197(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Defects in the cappuccino -LRB- cno -RRB- gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak_syndrome by an AP-3-independent mechanism .
8388667	0	coagulation_factor_IX	14,35	Christmas_factor	37,53	coagulation factor IX	Christmas factor	2158	2158	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of coagulation_factor_IX -LRB- Christmas_factor -RRB- in human hepatoma -LRB- HepG2 -RRB- cell cultures after retroviral vector-mediated transfer .
7904478	0	coagulation_factor_IX	67,88	Gla	38,41	coagulation factor IX	Gla	2158	2717	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	Ca -LRB- 2 + -RRB- - dependent interactions between Gla and EGF domains in human coagulation_factor_IX .
8698336	0	coagulation_factor_V	27,47	factor_V_Leiden	54,69	coagulation factor V	factor V Leiden	2153	2153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The G1691A mutation of the coagulation_factor_V gene -LRB- factor_V_Leiden -RRB- is rare in Chinese : an analysis of 618 individuals .
25504041	0	coagulation_factor_VII	18,40	tumor_necrosis_factor-a	70,93	coagulation factor VII	tumor necrosis factor-a	14068(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY enhanced|nsubjpass|production enhanced|nmod|END_ENTITY	The production of coagulation_factor_VII by adipocytes is enhanced by tumor_necrosis_factor-a or isoproterenol .
11057864	0	coagulation_factor_VIII	33,56	CD4	17,20	coagulation factor VIII	CD4	2157	920	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	Sensitization of CD4 + T cells to coagulation_factor_VIII : response in congenital and acquired_hemophilia patients and in healthy subjects .
12911593	0	coagulation_factor_VIII	57,80	CD4	6,9	coagulation factor VIII	CD4	2157	920	Gene	Gene	domain|nmod|START_ENTITY epitope|nmod|domain epitope|nsubj|T-cell T-cell|compound|END_ENTITY	Human CD4 + T-cell epitope repertoire on the C2 domain of coagulation_factor_VIII .
15304045	0	coagulation_factor_VIII	63,86	CD4	28,31	coagulation factor VIII	CD4	2157	920	Gene	Gene	domain|nmod|START_ENTITY T|nmod|domain T|nsubj|repertoire repertoire|nmod|END_ENTITY	Epitope repertoire of human CD4 -LRB- + -RRB- T cells on the A3 domain of coagulation_factor_VIII .
17479189	0	coagulation_factor_VIII	49,72	CD4	23,26	coagulation factor VIII	CD4	2157	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Cytokine production by CD4 + T cells specific for coagulation_factor_VIII in healthy subjects and haemophilia_A patients .
17209060	0	coagulation_factor_VIII	33,56	FVIII	58,63	coagulation factor VIII	FVIII	2157	2157	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A sequence variation scan of the coagulation_factor_VIII -LRB- FVIII -RRB- structural gene and associations with plasma FVIII activity levels .
11159521	0	coagulation_factor_X	20,40	GATA-4	60,66	coagulation factor X	GATA-4	2159	2626	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of human coagulation_factor_X gene expression by GATA-4 and the Sp family of transcription factors .
19661487	0	coagulation_factor_XI	18,39	apolipoprotein_E_receptor_2	65,92	coagulation factor XI	apolipoprotein E receptor 2	109821(Tax:10090)	16975(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of coagulation_factor_XI as a ligand for platelet apolipoprotein_E_receptor_2 -LRB- ApoER2 -RRB- .
16638441	0	coagulation_factor_XII	26,48	Hageman_factor	50,64	coagulation factor XII	Hageman factor	2161	2161	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Missense mutations in the coagulation_factor_XII -LRB- Hageman_factor -RRB- gene in hereditary_angioedema with normal C1 inhibitor .
7934914	0	coat-protein	32,44	MS2	59,62	coat-protein	MS2	64083	100271694	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Translational initiation at the coat-protein gene of phage MS2 : native upstream RNA relieves inhibition by local secondary structure .
19896716	0	coat_protein	17,29	C1q	36,39	coat protein	C1q	64083	712	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Human_astrovirus coat_protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation .
16979766	0	cocaine-amphetamine-regulated_transcript	47,87	CART	89,93	cocaine-amphetamine-regulated transcript	CART	29131(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nicotine administration effects on feeding and cocaine-amphetamine-regulated_transcript -LRB- CART -RRB- expression in the hypothalamus .
10574510	0	cocaine_and_amphetamine-regulated_transcript	31,75	CART	77,81	cocaine and amphetamine-regulated transcript	CART	9607	9607	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence variants in the human cocaine_and_amphetamine-regulated_transcript -LRB- CART -RRB- gene in subjects with early onset obesity .
11602226	0	cocaine_and_amphetamine-regulated_transcript	31,75	CART	77,81	cocaine and amphetamine-regulated transcript	CART	29131(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The effect of adrenalectomy on cocaine_and_amphetamine-regulated_transcript -LRB- CART -RRB- expression in the hypothalamic nuclei of the rat .
20826136	0	cocaine_and_amphetamine_regulated_transcript	64,108	CART	110,114	cocaine and amphetamine regulated transcript	CART	29131(Tax:10116)	29131(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of reboxetine and citalopram pretreatment on changes in cocaine_and_amphetamine_regulated_transcript -LRB- CART -RRB- expression in rat brain induced by the forced swimming test .
24174573	0	cocaine_and_amphetamine_regulated_transcript	29,73	CART	103,107	cocaine and amphetamine regulated transcript	CART	493726(Tax:9913)	493726(Tax:9913)	Gene	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	Regulation of granulosa cell cocaine_and_amphetamine_regulated_transcript -LRB- CART -RRB- binding and effect of CART signaling inhibitor on granulosa cell estradiol production during dominant follicle selection in cattle .
8631784	0	coenzyme_A_synthase	103,122	growth_hormone	129,143	coenzyme A synthase	growth hormone	80347	2688	Gene	Gene	expression|nmod|START_ENTITY expression|dep|gene gene|compound|END_ENTITY	Tissue-specific expression and dietary regulation of chimeric mitochondrial 3-hydroxy-3-methylglutaryl coenzyme_A_synthase / human growth_hormone gene in transgenic_mice .
10401580	0	cofactor_A	29,39	p14	24,27	cofactor A	p14	6902	11102	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulated expression of p14 -LRB- cofactor_A -RRB- during spermatogenesis .
17043641	0	cofactor_of_BRCA1	43,60	COBRA1	62,68	cofactor of BRCA1	COBRA1	25920	25920	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of clustered gene expression by cofactor_of_BRCA1 -LRB- COBRA1 -RRB- in breast_cancer cells .
22899846	0	cofilin	15,22	AIP1	0,4	cofilin	AIP1	37841(Tax:7227)	39505(Tax:7227)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	AIP1 acts with cofilin to control actin dynamics during epithelial morphogenesis .
10366597	0	cofilin	21,28	Aip1p	0,5	cofilin	Aip1p	850676(Tax:4932)	855117(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Aip1p interacts with cofilin to disassemble actin filaments .
11422377	0	cofilin	38,45	CFL2	47,51	cofilin	CFL2	1072	1073	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of human muscle type cofilin -LRB- CFL2 -RRB- in normal and regenerating muscle .
22270398	0	cofilin	14,21	CaMKII	34,40	cofilin	CaMKII	1072	818	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of cofilin activity by CaMKII and calcineurin .
18045906	0	cofilin	16,23	Cdc42	0,5	cofilin	Cdc42	1072	998	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cdc42 regulates cofilin during the establishment of neuronal polarity .
19654210	0	cofilin	76,83	Coronin_2A	0,10	cofilin	Coronin 2A	1072	7464	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	Coronin_2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway .
19704022	0	cofilin	20,27	Cortactin	0,9	cofilin	Cortactin	1072	2017	Gene	Gene	activities|compound|START_ENTITY regulates|dobj|activities regulates|nsubj|END_ENTITY	Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation .
23874890	0	cofilin	90,97	HIF-1a	80,86	cofilin	HIF-1a	1072	3091	Gene	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	Hypoxia modulates fibroblastic architecture , adhesion and migration : a role for HIF-1a in cofilin regulation and cytoplasmic actin distribution .
16230460	0	cofilin	35,42	LIM_kinase	55,65	cofilin	LIM kinase	1072	3984	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Spatial and temporal regulation of cofilin activity by LIM_kinase and Slingshot is critical for directional cell migration .
18096821	0	cofilin	19,26	LIM_kinase	39,49	cofilin	LIM kinase	1072	3984	Gene	Gene	activity|compound|START_ENTITY activity|nmod|phosphatase phosphatase|compound|END_ENTITY	Dual regulation of cofilin activity by LIM_kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells .
18332102	0	cofilin	42,49	LIM_kinase	19,29	cofilin	LIM kinase	1072	3984	Gene	Gene	phosphorylation|compound|START_ENTITY regulate|dobj|phosphorylation inhibits|xcomp|regulate inhibits|dobj|END_ENTITY	Nischarin inhibits LIM_kinase to regulate cofilin phosphorylation and cell invasion .
19567672	0	cofilin	75,82	Protein_kinase_D	0,16	cofilin	Protein kinase D	1072	5587	Gene	Gene	phosphatase|compound|START_ENTITY phosphorylation|nmod|phosphatase regulates|nmod|phosphorylation regulates|nsubj|END_ENTITY	Protein_kinase_D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like .
21832093	0	cofilin	27,34	Protein_kinase_D	0,16	cofilin	Protein kinase D	1072	5587	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Protein_kinase_D regulates cofilin activity through p21-activated_kinase_4 .
19556892	0	cofilin	24,31	kip1	69,73	cofilin	kip1	1072	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulated expression of cofilin and the consequent regulation of p27 -LRB- kip1 -RRB- are essential for G -LRB- 1 -RRB- phase progression .
16571634	0	cofilin/ADF	36,47	Twinstar	0,8	cofilin/ADF	Twinstar	37841(Tax:7227)	37841(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Twinstar , the Drosophila homolog of cofilin/ADF , is required for planar cell polarity patterning .
23831569	0	cofilin_1	14,23	EWS	0,3	cofilin 1	EWS	1072	2130	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	EWS represses cofilin_1 expression by inducing nuclear retention of cofilin_1 mRNA .
26704451	0	cofilin_1	62,71	NudC	0,4	cofilin 1	NudC	321496(Tax:7955)	393893(Tax:7955)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin_1 .
19752190	0	cofilin_2	34,43	Muscle_LIM_protein	0,18	cofilin 2	Muscle LIM protein	1073	8048	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Muscle_LIM_protein interacts with cofilin_2 and regulates F-actin dynamics in cardiac_and_skeletal_muscle .
15262978	0	coiled-coil-DIX1	23,39	Axin	87,91	coiled-coil-DIX1	Axin	85458	8312	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms .
10806077	0	coilin	49,55	Coil	62,66	coilin	Coil	12812(Tax:10090)	12812(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and characterization of the murine p80 coilin gene , Coil .
23726919	0	coilin	34,40	UBL5	6,10	coilin	UBL5	8161	59286	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	Human UBL5 protein interacts with coilin and meets the Cajal bodies .
10806077	0	coilin	49,55	p80	45,48	coilin	p80	12812(Tax:10090)	12812(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Structure and characterization of the murine p80 coilin gene , Coil .
15808856	0	col-43	69,75	collagen	55,63	col-43	collagen	179187(Tax:6239)	186127(Tax:6239)	Gene	Gene	START_ENTITY|nsubj|gene gene|compound|END_ENTITY	The homeoproteins MAB-18 and CEH-14 insulate the dauer collagen gene col-43 from activation by the adjacent promoter of the Spermatheca gene sth-1 in Caenorhabditis_elegans .
24744467	0	col1a1	59,65	collagen_type_I_alpha_1	34,57	col1a1	collagen type I alpha 1	1277	1277	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The +1245 g/t polymorphisms in the collagen_type_I_alpha_1 -LRB- col1a1 -RRB- gene in polish skiers with anterior_cruciate_ligament_injury .
16868559	0	cold-induced_autoinflammatory_syndrome_1	66,106	CIAS1	108,113	cold-induced autoinflammatory syndrome 1	CIAS1	114548	114548	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An intronic variable number of tandem repeat polymorphisms of the cold-induced_autoinflammatory_syndrome_1 -LRB- CIAS1 -RRB- gene modifies gene expression and is associated with essential hypertension .
21035374	0	cold-induced_autoinflammatory_syndrome_1	65,105	CIAS1	107,112	cold-induced autoinflammatory syndrome 1	CIAS1	114548	114548	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Distribution of 42-bp variable tandem repeat polymorphism of the cold-induced_autoinflammatory_syndrome_1 -LRB- CIAS1 -RRB- gene in eight human populations .
9422546	0	cold-inducible_RNA-binding_protein	24,58	CIRP	60,64	cold-inducible RNA-binding protein	CIRP	12696(Tax:10090)	12696(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of cold-inducible_RNA-binding_protein -LRB- CIRP -RRB- in male germ cells at elevated temperature .
9571190	0	cold-inducible_RNA-binding_protein	22,56	Cirp	58,62	cold-inducible RNA-binding protein	Cirp	12696(Tax:10090)	12696(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Diurnal change of the cold-inducible_RNA-binding_protein -LRB- Cirp -RRB- expression in mouse brain .
23046908	0	cold-inducible_RNA-binding_protein	82,116	Sp1	46,49	cold-inducible RNA-binding protein	Sp1	1153	6667	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible_RNA-binding_protein -LRB- cirp -RRB- expression in mammalian cells .
23046908	0	cold-inducible_RNA-binding_protein	82,116	cirp	118,122	cold-inducible RNA-binding protein	cirp	1153	1153	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible_RNA-binding_protein -LRB- cirp -RRB- expression in mammalian cells .
23437386	0	cold-inducible_RNA_binding_protein	25,59	interleukin_1b	74,88	cold-inducible RNA binding protein	interleukin 1b	1153	3553	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	NF-kB-dependent role for cold-inducible_RNA_binding_protein in regulating interleukin_1b .
15030510	0	colitis	196,203	MAdCAM-1	126,134	LTbetaR	MAdCAM-1	17000(Tax:10090)	17123(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Blocking lymphotoxin-beta_receptor activation diminishes inflammation via reduced mucosal_addressin_cell_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- expression and leucocyte margination in chronic DSS-induced colitis .
15030510	0	colitis	196,203	mucosal_addressin_cell_adhesion_molecule-1	82,124	LTbetaR	mucosal addressin cell adhesion molecule-1	17000(Tax:10090)	17123(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Blocking lymphotoxin-beta_receptor activation diminishes inflammation via reduced mucosal_addressin_cell_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- expression and leucocyte margination in chronic DSS-induced colitis .
22829018	0	collagen	81,89	Ets-1	47,52	collagen	Ets-1	1278	2113	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Inhibitory effects of the transcription factor Ets-1 on the expression of type I collagen in TGF-b1-stimulated renal epithelial cells .
15808856	0	collagen	55,63	col-43	69,75	collagen	col-43	186127(Tax:6239)	179187(Tax:6239)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nsubj|gene	The homeoproteins MAB-18 and CEH-14 insulate the dauer collagen gene col-43 from activation by the adjacent promoter of the Spermatheca gene sth-1 in Caenorhabditis_elegans .
26995940	0	collagen_1A1	17,29	COL1A1	31,37	collagen 1A1	COL1A1	1277	1277	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of collagen_1A1 -LRB- COL1A1 -RRB- gene and their relation to bone mineral density in postmenopausal women .
21769867	0	collagen_1A1	19,31	MiR-133a	0,8	collagen 1A1	MiR-133a	29393(Tax:10116)	100314030(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MiR-133a regulates collagen_1A1 : potential role of miR-133a in myocardial_fibrosis in angiotensin_II-dependent hypertension .
21769867	0	collagen_1A1	19,31	miR-133a	51,59	collagen 1A1	miR-133a	29393(Tax:10116)	100314030(Tax:10116)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	MiR-133a regulates collagen_1A1 : potential role of miR-133a in myocardial_fibrosis in angiotensin_II-dependent hypertension .
7700721	0	collagen_II	39,50	COL2A1	52,58	collagen II	COL2A1	1280	1280	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Kniest_dysplasia is caused by dominant collagen_II -LRB- COL2A1 -RRB- mutations : parental somatic mosaicism manifesting as Stickler phenotype and mild spondyloepiphyseal_dysplasia .
1358979	0	collagen_VII	28,40	COL7A1	42,48	collagen VII	COL7A1	1294	1294	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic linkage between the collagen_VII -LRB- COL7A1 -RRB- gene and the autosomal dominant form of dystrophic_epidermolysis_bullosa in two Dutch kindreds .
15111613	0	collagen_XVIII	16,30	collagen_XVIII	61,75	collagen XVIII	collagen XVIII	80781	80781	Gene	Gene	Localization|nmod|START_ENTITY Localization|nmod|END_ENTITY	Localization of collagen_XVIII and the endostatin portion of collagen_XVIII in aged human control eyes and eyes with age-related_macular_degeneration .
15111613	0	collagen_XVIII	61,75	collagen_XVIII	16,30	collagen XVIII	collagen XVIII	80781	80781	Gene	Gene	Localization|nmod|START_ENTITY Localization|nmod|END_ENTITY	Localization of collagen_XVIII and the endostatin portion of collagen_XVIII in aged human control eyes and eyes with age-related_macular_degeneration .
12237301	0	collagen_XVIII	48,62	endostatin	63,73	collagen XVIII	endostatin	80781	80781	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Laminin modulates morphogenic properties of the collagen_XVIII endostatin domain .
15451191	0	collagen_XVIII	22,36	endostatin	90,100	collagen XVIII	endostatin	80781	80781	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of collagen_XVIII and its cleavage product , the angiogenesis inhibitor endostatin , at the fetal-maternal interface .
18483174	0	collagen_receptor	80,97	Ddr2	104,108	collagen receptor	Ddr2	16398(Tax:10090)	18214(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel dwarfism with gonadal_dysfunction due to loss-of-function allele of the collagen_receptor gene , Ddr2 , in the mouse .
23036951	0	collagen_type_I	75,90	COL1A1	92,98	collagen type I	COL1A1	1277	1277	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Controlling fibrous capsule formation through long-term down-regulation of collagen_type_I -LRB- COL1A1 -RRB- expression by nanofiber-mediated siRNA gene silencing .
23079621	0	collagen_type_I	54,69	RFX5	19,23	collagen type I	RFX5	1278	5993	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	SIRT1 deacetylates RFX5 and antagonizes repression of collagen_type_I -LRB- COL1A2 -RRB- transcription in smooth muscle cells .
9915573	0	collagen_type_II	61,77	COL2A1	79,85	collagen type II	COL2A1	1280	1280	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Restoration of normal bone development by human homologue of collagen_type_II -LRB- COL2A1 -RRB- gene in Col2a1 null mice .
15082485	0	collagen_type_II_alpha1	57,80	COL2A1	82,88	collagen type II alpha1	COL2A1	1280	1280	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Insulin-like growth factor I gene promoter polymorphism , collagen_type_II_alpha1 -LRB- COL2A1 -RRB- gene , and the prevalence of radiographic_osteoarthritis : the Rotterdam Study .
24566004	0	collagen_type_I_alpha1	20,42	COL1A1	44,50	collagen type I alpha1	COL1A1	1277	1277	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Combined effects of collagen_type_I_alpha1 -LRB- COL1A1 -RRB- Sp1 polymorphism and osteoporosis risk factors on bone_mineral_density in Turkish postmenopausal women .
17551768	0	collagen_type_I_alpha1	43,65	COLIA1	67,73	collagen type I alpha1	COLIA1	1277	1277	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The -1997 _ G/T and Sp1 polymorphisms in the collagen_type_I_alpha1 -LRB- COLIA1 -RRB- gene in relation to changes in femoral neck bone_mineral_density and the risk of fracture in the elderly : the Rotterdam study .
20338660	0	collagen_type_I_alpha2	15,37	Let-7g	0,6	collagen type I alpha2	Let-7g	1278	406890	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Let-7g targets collagen_type_I_alpha2 and inhibits cell migration_in_hepatocellular_carcinoma .
10913946	0	collagen_type_I_alpha_1	41,64	COLIA1	66,72	collagen type I alpha 1	COLIA1	1277	1277	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Sp1 binding site polymorphism in the collagen_type_I_alpha_1 -LRB- COLIA1 -RRB- gene is not associated with bone_mineral_density in healthy children , adolescents , and young adults .
24744467	0	collagen_type_I_alpha_1	34,57	col1a1	59,65	collagen type I alpha 1	col1a1	1277	1277	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The +1245 g/t polymorphisms in the collagen_type_I_alpha_1 -LRB- col1a1 -RRB- gene in polish skiers with anterior_cruciate_ligament_injury .
9572733	0	collagenase-1	36,49	Rac1	8,12	collagenase-1	Rac1	100009110(Tax:9986)	100339873(Tax:9986)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change .
11400153	0	collagenase-2	8,21	MMP-8	23,28	collagenase-2	MMP-8	4317	4317	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	In vivo collagenase-2 -LRB- MMP-8 -RRB- expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis .
12081207	0	collagenase-2	29,42	MMP-8	44,49	collagenase-2	MMP-8	4317	4317	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of collagenase-2 -LRB- MMP-8 -RRB- in head and neck squamous_cell_carcinomas .
12429813	0	collagenase-2	35,48	MMP-8	50,55	collagenase-2	MMP-8	4317	4317	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Airway_obstruction correlates with collagenase-2 -LRB- MMP-8 -RRB- expression and activation in bronchial_asthma .
11453113	0	collagenase-2	13,26	interleukin-1beta	75,92	collagenase-2	interleukin-1beta	4317	3553	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of collagenase-2 -LRB- matrix_metalloproteinase-8 -RRB- gene expression by interleukin-1beta in human gingival fibroblasts .
16409253	0	collagenase-2	38,51	matrix_metalloproteinase-8	53,79	collagenase-2	matrix metalloproteinase-8	4317	4317	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Capsaicin-induced local elevations in collagenase-2 -LRB- matrix_metalloproteinase-8 -RRB- levels in human gingival crevice fluid .
10830307	0	collagenase-3	42,55	Basic_fibroblast_growth_factor	0,30	collagenase-3	Basic fibroblast growth factor	171052(Tax:10116)	54250(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor stimulates collagenase-3 promoter activity in osteoblasts through an activator_protein-1-binding site .
7607691	0	collagenase-3	10,23	CLG3	25,29	collagenase-3	CLG3	4322	4322	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human collagenase-3 -LRB- CLG3 -RRB- gene is located on chromosome 11q22 .3 clustered to other members of the matrix metalloproteinase gene family .
10671545	0	collagenase-3	42,55	Parathyroid_hormone	0,19	collagenase-3	Parathyroid hormone	171052(Tax:10116)	24694(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|amod|END_ENTITY	Parathyroid_hormone regulation of the rat collagenase-3 promoter by protein_kinase_A-dependent transactivation of core_binding_factor_alpha1 .
10671545	0	collagenase-3	42,55	core_binding_factor_alpha1	114,140	collagenase-3	core binding factor alpha1	171052(Tax:10116)	367218(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Parathyroid_hormone regulation of the rat collagenase-3 promoter by protein_kinase_A-dependent transactivation of core_binding_factor_alpha1 .
9009143	0	collagenase_3	42,55	Transforming_growth_factor_beta1	0,32	collagenase 3	Transforming growth factor beta1	171052(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta1 inhibits collagenase_3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures .
19755421	0	collapsin_response_mediator_protein_2	21,58	CRMP-2	60,66	collapsin response mediator protein 2	CRMP-2	1808	1808	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	An atypical role for collapsin_response_mediator_protein_2 -LRB- CRMP-2 -RRB- in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels .
22279220	0	collapsin_response_mediator_protein_2	26,63	CRMP2	19,24	collapsin response mediator protein 2	CRMP2	12934(Tax:10090)	12934(Tax:10090)	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of CRMP2 -LRB- collapsin_response_mediator_protein_2 -RRB- is involved in proper dendritic field organization .
24904280	0	collapsin_response_mediator_protein_2	27,64	CRMP2	66,71	collapsin response mediator protein 2	CRMP2	1808	1808	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of collapsin_response_mediator_protein_2 -LRB- CRMP2 -RRB- phosphorylation by GSK3 and CDK5 following traumatic_brain_injury .
7656593	0	colligin-2	64,74	CBP2	81,85	colligin-2	CBP2	871	871	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation , characterization and chromosomal assignment of human colligin-2 gene -LRB- CBP2 -RRB- .
3793269	0	colon-associated_antigen	48,72	CAA	74,77	colon-associated antigen	CAA	10194	10194	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Immunological characterization of a novel human colon-associated_antigen -LRB- CAA -RRB- by a monoclonal antibody .
17395983	0	colon_cancer	111,123	Snail1	95,101	beta-catenin	Snail1	1499	6615	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin _ D3 is abrogated by Snail1 in human colon_cancer cells .
6332035	0	colony-stimulating_factor	71,96	CSF	98,101	colony-stimulating factor	CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Retroviruses released from a human tumor xenograft in nude_mice induce colony-stimulating_factor -LRB- CSF -RRB- activity in human fibroblastic cells .
1352526	0	colony-stimulating_factor	110,135	CSF-1	137,142	colony-stimulating factor	CSF-1	1435	1435	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Contributions of the CD2 and CD28 T lymphocyte activation pathways to the regulation of the expression of the colony-stimulating_factor -LRB- CSF-1 -RRB- gene .
3485107	0	colony-stimulating_factor	25,50	CSF-1	52,57	colony-stimulating factor	CSF-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Persistent production of colony-stimulating_factor -LRB- CSF-1 -RRB- by cloned bone marrow stromal cell line D2XRII after X-irradiation .
6094601	0	colony-stimulating_factor	49,74	CSF-1	76,81	colony-stimulating factor	CSF-1	12981(Tax:10090)	12977(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Receptor-mediated binding and internalization of colony-stimulating_factor -LRB- CSF-1 -RRB- by mouse peritoneal exudate macrophages .
9281358	0	colony-stimulating_factor	192,217	Csfgm	219,224	colony-stimulating factor	Csfgm	12977(Tax:10090)	12981(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Priming of mouse macrophages with the macrophage colony-stimulating_factor -LRB- CSF-1 -RRB- induces a variety of pathways that regulate expression of the interleukin_6 -LRB- Il6 -RRB- and granulocyte-macrophage colony-stimulating_factor -LRB- Csfgm -RRB- genes .
15867372	0	colony-stimulating_factor-1	88,115	CSF-1	117,122	colony-stimulating factor-1	CSF-1	1435	1435	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase binds to the AU-Rich 3 ' untranslated region of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- messenger RNA in human ovarian_cancer cells : possible role in CSF-1 posttranscriptional regulation and tumor phenotype .
1791839	0	colony-stimulating_factor-1	14,41	CSF-1	43,48	colony-stimulating factor-1	CSF-1	1435	1435	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Expression of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- messenger RNA in human endometrial glands during the menstrual cycle : molecular cloning of a novel transcript that predicts a cell surface form of CSF-1 .
2151455	0	colony-stimulating_factor-1	14,41	CSF-1	43,48	colony-stimulating factor-1	CSF-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of colony-stimulating_factor-1 -LRB- CSF-1 -RRB- by mouse astroglia in vitro .
22096574	0	colony-stimulating_factor-1	4,31	CSF-1	33,38	colony-stimulating factor-1	CSF-1	1435	1435	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The colony-stimulating_factor-1 -LRB- CSF-1 -RRB- receptor sustains ERK1/2 activation and proliferation in breast_cancer cell lines .
9116300	0	colony-stimulating_factor-1	22,49	CSF-1	180,185	colony-stimulating factor-1	CSF-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Increased circulating colony-stimulating_factor-1 -LRB- CSF-1 -RRB- in SJL/J mice with radiation-induced acute_myeloid_leukemia -LRB- AML -RRB- is associated with autocrine regulation of AML cells by CSF-1 .
1381374	0	colony-stimulating_factor-1	30,57	Interleukin-1_beta	0,18	colony-stimulating factor-1	Interleukin-1 beta	1435	3553	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates colony-stimulating_factor-1 production in placental villous core mesenchymal cells .
9694732	0	colony-stimulating_factor-1	62,89	c-Fms	108,113	colony-stimulating factor-1	c-Fms	12977(Tax:10090)	12978(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Macrophage lineage cells in inflammation : characterization by colony-stimulating_factor-1 -LRB- CSF-1 -RRB- _ receptor -LRB- c-Fms -RRB- , ER-MP58 , and ER-MP20 -LRB- Ly-6C -RRB- expression .
15958574	0	colony-stimulating_factor-1	65,92	epidermal_growth_factor	93,116	colony-stimulating factor-1	epidermal growth factor	1435	1950	Gene	Gene	loop|amod|START_ENTITY loop|compound|END_ENTITY	Macrophages promote the invasion of breast_carcinoma cells via a colony-stimulating_factor-1 / epidermal_growth_factor paracrine loop .
23924854	0	colony-stimulating_factor-1	48,75	glycoprotein_nonmetastatic_B	16,44	colony-stimulating factor-1	glycoprotein nonmetastatic B	1435	10457	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of glycoprotein_nonmetastatic_B by colony-stimulating_factor-1 and epithelial_cell_adhesion_molecule in hepatocellular_carcinoma cells .
7545471	0	colony-stimulating_factor-1	102,129	interferon-gamma	55,71	colony-stimulating factor-1	interferon-gamma	1435	3458	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating_factor-1 .
9602296	0	colony-stimulating_factor-1	41,68	interleukin-1_alpha	18,37	colony-stimulating factor-1	interleukin-1 alpha	78965(Tax:10116)	24493(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	In vivo effect of interleukin-1_alpha on colony-stimulating_factor-1 gene expression in the dental follicle of the rat molar .
16648572	0	colony-stimulating_factor-1_receptor	37,73	c-Fms	75,80	colony-stimulating factor-1 receptor	c-Fms	1436	1436	Gene	Gene	tyrosine|amod|START_ENTITY tyrosine|appos|END_ENTITY	Inhibition of phosphorylation of the colony-stimulating_factor-1_receptor -LRB- c-Fms -RRB- tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors .
7964503	0	colony-stimulating_factor-1_receptor	135,171	c-fms	173,178	colony-stimulating factor-1 receptor	c-fms	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Opposing actions of c-ets/PU .1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating_factor-1_receptor -LRB- c-fms -RRB- genes .
1691932	0	colony-stimulating_factor_1	6,33	CSF-1	35,40	colony-stimulating factor 1	CSF-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Human colony-stimulating_factor_1 -LRB- CSF-1 -RRB- receptor confers CSF-1 responsiveness to interleukin-3-dependent 32DC13 mouse myeloid cells and abrogates differentiation in response to granulocyte CSF .
24955855	0	colony-stimulating_factor_1_receptor	81,117	TACE	38,42	colony-stimulating factor 1 receptor	TACE	1436	6868	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and mutagenesis of the TACE and y-secretase cleavage sites in the colony-stimulating_factor_1_receptor .
11289721	0	colony-stimulating_factor_2	51,78	CSF2	80,84	colony-stimulating factor 2	CSF2	1437	1437	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel single nucleotide polymorphisms of the human colony-stimulating_factor_2 -LRB- CSF2 -RRB- gene identified by sequencing the entire gene .
24403076	0	colony-stimulating_factor_3_receptor	49,85	CSF3R	87,92	colony-stimulating factor 3 receptor	CSF3R	1441	1441	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Ligand independence of the T618I mutation in the colony-stimulating_factor_3_receptor -LRB- CSF3R -RRB- protein results from loss_of_O-linked_glycosylation and increased receptor dimerization .
310773	0	colony_stimulating_factor	21,46	CSF	16,19	colony stimulating factor	CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of CSF -LRB- colony_stimulating_factor -RRB- in kidney of the mouse .
417824	1	colony_stimulating_factor	117,142	CSF	143,146	colony stimulating factor	CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Comparison with colony_stimulating_factor CSF -RRB- -RSB- .
2670003	0	colony_stimulating_factor	23,48	Lactoferrin	0,11	colony stimulating factor	Lactoferrin	12981(Tax:10090)	17002(Tax:10090)	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Lactoferrin stimulates colony_stimulating_factor production in vitro and in vivo .
3494061	0	colony_stimulating_factor	13,38	interleukin_1_alpha	62,81	colony stimulating factor	interleukin 1 alpha	1437	3552	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of colony_stimulating_factor in vivo by recombinant interleukin_1_alpha and recombinant tumor_necrosis_factor_alpha 1 .
8554432	0	colony_stimulating_factor-1	19,46	CSF-1	48,53	colony stimulating factor-1	CSF-1	1435	1435	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Enhanced levels of colony_stimulating_factor-1 -LRB- CSF-1 -RRB- in sera and seminal plasma of antisperm antibody-positive infertile men .
9039846	0	colony_stimulating_factor-1	32,59	CSF-1	61,66	colony stimulating factor-1	CSF-1	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Myoblast-mediated expression of colony_stimulating_factor-1 -LRB- CSF-1 -RRB- in the cytokine-deficient op/op mouse .
16623714	0	colony_stimulating_factor-1_receptor	77,113	SLAP-2	50,56	colony stimulating factor-1 receptor	SLAP-2	12978(Tax:10090)	77799(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	A potential role for the Src-like_adapter_protein SLAP-2 in signaling by the colony_stimulating_factor-1_receptor .
22197934	0	colony_stimulating_factor_1_receptor	17,53	CSF1R	55,60	colony stimulating factor 1 receptor	CSF1R	1436	1436	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the colony_stimulating_factor_1_receptor -LRB- CSF1R -RRB- gene cause hereditary diffuse_leukoencephalopathy with spheroids .
21885153	0	colony_stimulating_factor_1_receptor	133,169	Csf1r	171,176	colony stimulating factor 1 receptor	Csf1r	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin_alpha_X -LRB- Itgax , CD11c -RRB- and colony_stimulating_factor_1_receptor -LRB- Csf1r , CD115 -RRB- expression fails to discriminate dendritic cells from macrophages .
2525226	0	common_acute_lymphoblastic_leukaemia_antigen	18,62	CALLA	64,69	common acute lymphoblastic leukaemia antigen	CALLA	4311	4311	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the common_acute_lymphoblastic_leukaemia_antigen -LRB- CALLA -RRB- in the human breast .
2415623	0	common_acute_lymphoblastic_leukemia_antigen	18,61	CALLA	63,68	common acute lymphoblastic leukemia antigen	CALLA	4311	4311	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the common_acute_lymphoblastic_leukemia_antigen -LRB- CALLA -RRB- on the surface of individual cells of human lymphoblastoid lines .
6339629	0	common_acute_lymphoblastic_leukemia_antigen	14,57	CALLA	59,64	common acute lymphoblastic leukemia antigen	CALLA	4311	4311	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of common_acute_lymphoblastic_leukemia_antigen -LRB- CALLA -RRB- on human malignant_melanoma cell lines .
8392520	0	common_acute_lymphoblastic_leukemia_antigen	14,57	CD_10	59,64	common acute lymphoblastic leukemia antigen	CD 10	4311	4311	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of common_acute_lymphoblastic_leukemia_antigen -LRB- CD_10 -RRB- by myelinated fibers of the peripheral nervous system .
11246656	0	common_cytokine_receptor_gamma_chain	23,59	CD132	61,66	common cytokine receptor gamma chain	CD132	3561	3561	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abundant expression of common_cytokine_receptor_gamma_chain -LRB- CD132 -RRB- in rheumatoid_joints .
10640728	0	common_gamma-chain	88,106	IL-2	0,4	common gamma-chain	IL-2	16186(Tax:10090)	16183(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY due|xcomp|signaling due|nsubj|unresponsiveness unresponsiveness|compound|END_ENTITY	IL-2 unresponsiveness in anergic CD4 + T cells is due to defective signaling through the common_gamma-chain of the IL-2 receptor .
10640728	0	common_gamma-chain	88,106	IL-2	114,118	common gamma-chain	IL-2	16186(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	IL-2 unresponsiveness in anergic CD4 + T cells is due to defective signaling through the common_gamma-chain of the IL-2 receptor .
10946282	0	common_gamma-chain	101,119	IL-2	29,33	common gamma-chain	IL-2	3561	3558	Gene	Gene	tail|nmod|START_ENTITY portion|nmod|tail depends|nmod|portion depends|nsubj|internalization internalization|nmod|END_ENTITY	Efficient internalization of IL-2 depends on the distal portion of the cytoplasmic tail of the IL-2R common_gamma-chain and a lymphoid cell environment .
18981091	0	common_gamma-chain	4,22	IL-2	33,37	common gamma-chain	IL-2	3561	3558	Gene	Gene	cytokines|nsubj|START_ENTITY cytokines|xcomp|END_ENTITY	The common_gamma-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 induce the expression of programmed death-1 and its ligands .
18981091	0	common_gamma-chain	4,22	IL-7	39,43	common gamma-chain	IL-7	3561	3574	Gene	Gene	cytokines|nsubj|START_ENTITY cytokines|ccomp|induce induce|nsubj|END_ENTITY	The common_gamma-chain cytokines IL-2 , IL-7 , IL-15 , and IL-21 induce the expression of programmed death-1 and its ligands .
9190922	0	common_gamma-chain	19,37	IL-7	53,57	common gamma-chain	IL-7	3561	3574	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Association of the common_gamma-chain with the human IL-7 receptor is modulated by T cell activation .
20706769	0	complement_C3	6,19	C-reactive_protein	91,109	complement C3	C-reactive protein	718	1401	Gene	Gene	has|nsubj|START_ENTITY has|nmod|END_ENTITY	Serum complement_C3 has a stronger association with insulin resistance than high sensitive C-reactive_protein in non-diabetic Chinese .
21316661	0	complement_C3	6,19	C-reactive_protein	93,111	complement C3	C-reactive protein	718	1401	Gene	Gene	has|nsubj|START_ENTITY has|nmod|END_ENTITY	Serum complement_C3 has a stronger association with insulin resistance than high-sensitivity C-reactive_protein in women with polycystic_ovary_syndrome .
25488663	0	complement_C3	42,55	C3b	59,62	complement C3	C3b	718	718	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	A revised mechanism for the activation of complement_C3 to C3b : a molecular explanation of a disease-associated polymorphism .
7957570	0	complement_C3	24,37	CR2	14,17	complement C3	CR2	718	1380	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|dep|receptors	CR1 -LRB- CD35 -RRB- and CR2 -LRB- CD21 -RRB- complement_C3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus .
23628799	0	complement_C3	47,60	Hepatic_nuclear_factor_4a	0,25	complement C3	Hepatic nuclear factor 4a	718	3172	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hepatic_nuclear_factor_4a positively regulates complement_C3 expression and does not interfere with TNFa-mediated stimulation of C3 expression in HepG2 cells .
23168409	0	complement_C3	66,79	Peroxisome_proliferator-activated_receptor_a	0,44	complement C3	Peroxisome proliferator-activated receptor a	718	5465	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_a positively regulates complement_C3 expression but inhibits tumor necrosis factor a-mediated activation of C3 gene in mammalian hepatic-derived cells .
25813686	0	complement_C3	7,20	insulin	48,55	complement C3	insulin	718	3630	Gene	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|secretion secretion|compound|END_ENTITY	Plasma complement_C3 levels are associated with insulin secretion independently of adiposity measures in non-diabetic individuals .
2409614	0	complement_S-protein	15,35	S-protein	89,98	complement S-protein	S-protein	7448	7448	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|role role|nmod|END_ENTITY	Interaction of complement_S-protein with thrombin-antithrombin complexes : a role for the S-protein in haemostasis .
18635264	0	complement_anaphylatoxin_receptors	8,42	C3aR	44,48	complement anaphylatoxin receptors	C3aR	84007(Tax:10116)	84007(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of complement_anaphylatoxin_receptors -LRB- C3aR , C5aR -RRB- in the development of the rat cerebellum .
23299310	0	complement_component_3	12,34	C3	36,38	complement component 3	C3	12266(Tax:10090)	12266(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of complement_component_3 -LRB- C3 -RRB- in differentiation of myeloid-derived suppressor cells .
20108004	0	complement_factor_B	24,43	CFB	50,53	complement factor B	CFB	629	629	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the complement_factor_B gene -LRB- CFB -RRB- and atypical_hemolytic_uremic_syndrome .
26984954	0	complement_factor_B	46,65	Signal_Transducer_and_Activator_of_Transcription_1	80,130	complement factor B	Signal Transducer and Activator of Transcription 1	629	6772	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	The C-terminal tail of polycystin-1 regulates complement_factor_B expression by Signal_Transducer_and_Activator_of_Transcription_1 .
15448941	0	complement_factor_B	114,133	Sp152	79,84	complement factor B	Sp152	373308(Tax:7668)	373308(Tax:7668)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Constitutive expression and alternative splicing of the exons encoding SCRs in Sp152 , the sea urchin homologue of complement_factor_B .
18043728	0	complement_factor_H	18,37	CFH	39,42	complement factor H	CFH	3075	3075	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotypes in the complement_factor_H -LRB- CFH -RRB- gene : associations with drusen and advanced age-related macular_degeneration .
22302353	0	complement_factor_H	14,33	CFH	35,38	complement factor H	CFH	3075	3075	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of complement_factor_H -LRB- CFH -RRB- by multiple miRNAs in Alzheimer 's _ disease -LRB- AD -RRB- brain .
22509485	0	complement_factor_H	34,53	CFH	55,58	complement factor H	CFH	3075	3075	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Common micro RNAs -LRB- miRNAs -RRB- target complement_factor_H -LRB- CFH -RRB- regulation in Alzheimer 's _ disease -LRB- AD -RRB- and in age-related_macular_degeneration -LRB- AMD -RRB- .
23029250	0	complement_factor_H	41,60	Interleukin_27	0,14	complement factor H	Interleukin 27	3075	246778	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_27 induces the expression of complement_factor_H -LRB- CFH -RRB- in the retina .
10524238	0	complement_factor_I	108,127	CFI	129,132	complement factor I	CFI	3426	3426	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An initiator element and a proximal cis-acting sequence are essential for transcriptional activation of the complement_factor_I -LRB- CFI -RRB- gene .
18825487	0	complement_factor_I	19,38	CFI	40,43	complement factor I	CFI	3426	3426	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Molecular basis of complement_factor_I -LRB- CFI -RRB- polymorphism : one of two polymorphic suballeles responsible for CFI A is Japanese-specific .
19693526	0	complement_factor_I	40,59	CFI	61,64	complement factor I	CFI	3426	3426	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A hypervariable STR polymorphism in the complement_factor_I -LRB- CFI -RRB- gene : Asian-specific alleles .
3237219	0	complement_factor_P	16,35	properdin	37,46	complement factor P	properdin	5199	5199	Gene	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|appos|END_ENTITY	Biosynthesis of complement_factor_P -LRB- properdin -RRB- by the human pre-monocyte cell line -LRB- U-937 -RRB- .
8706338	0	complement_receptor_1	28,49	CR1	51,54	complement receptor 1	CR1	1378	1378	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Structural polymorphisms of complement_receptor_1 -LRB- CR1 -RRB- in systemic_lupus_erythematosus -LRB- SLE -RRB- patients and normal controls of three ethnic groups .
1706386	0	complement_receptor_2	30,51	CR2	53,56	complement receptor 2	CR2	1380	1380	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Characterization of the human complement_receptor_2 -LRB- CR2 , CD21 -RRB- promoter reveals sequences shared with regulatory regions of other developmentally restricted B cell proteins .
10786621	0	complement_receptor_type_1	51,77	CR1	79,82	complement receptor type 1	CR1	1378	1378	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter activity of the 5 ' flanking region of the complement_receptor_type_1 -LRB- CR1 -RRB- gene : basal and induced transcription .
11811640	0	complement_receptor_type_1	14,40	CR1	42,45	complement receptor type 1	CR1	1378	1378	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of complement_receptor_type_1 -LRB- CR1 -RRB- on erythrocytes of paracoccidiodomycosis patients .
16305660	0	complement_receptor_type_1	16,42	CR1	44,47	complement receptor type 1	CR1	1378	1378	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Low erythrocyte complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- expression in preeclamptic gestations .
2573360	0	complement_receptor_type_1	17,43	CR1	45,48	complement receptor type 1	CR1	1378	1378	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The frequency of complement_receptor_type_1 -LRB- CR1 -RRB- gene polymorphisms in nine families with multiple cases of systemic_lupus_erythematosus .
9614933	0	complement_receptor_type_1	12,38	CR1	40,43	complement receptor type 1	CR1	1378	1378	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of complement_receptor_type_1 -LRB- CR1 -RRB- expression on erythrocytes and of CR1 allelic markers in Caucasian and African American populations .
9950773	0	complement_receptor_type_1	30,56	CR1	58,61	complement receptor type 1	CR1	1378	1378	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Hypoxia-induced expression of complement_receptor_type_1 -LRB- CR1 , CD35 -RRB- in human vascular endothelial cells .
15713467	0	complement_receptor_type_2	27,53	C3d	65,68	complement receptor type 2	C3d	1380	100861467	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	Mutational analysis of the complement_receptor_type_2 -LRB- CR2/CD21 -RRB- - C3d interaction reveals a putative charged SCR1 binding site for C3d .
12244142	0	complement_receptor_type_2	20,46	CD21	48,52	complement receptor type 2	CD21	1380	1380	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human complement_receptor_type_2 -LRB- CD21 -RRB- in mice during early B cell development results in a reduction in mature B cells and hypogammaglobulinemia .
11091285	0	complement_receptor_type_2	26,52	CR2	54,57	complement receptor type 2	CR2	1380	1380	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of the complement_receptor_type_2 -LRB- CR2 , CD21 -RRB- by synovial fluid B and T lymphocytes .
1825940	0	complement_receptor_type_2	24,50	CR2	52,55	complement receptor type 2	CR2	1380	1380	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of complement_receptor_type_2 -LRB- CR2 -RRB- on neoplastic B cells of chronic_lymphocytic_leukaemia .
9570543	0	complement_receptor_type_2	93,119	CR2	121,124	complement receptor type 2	CR2	1380	1380	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An intronic silencer regulates B lymphocyte cell - and stage-specific expression of the human complement_receptor_type_2 -LRB- CR2 , CD21 -RRB- gene .
16162394	0	complexin_2	37,48	CPLX2	55,60	complexin 2	CPLX2	10814	10814	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural organization of the human complexin_2 gene -LRB- CPLX2 -RRB- and aspects of its functional activity .
19228884	0	concentrative_nucleoside_transporter-1	63,101	Hepatocyte_nuclear_factor-4alpha	0,32	concentrative nucleoside transporter-1	Hepatocyte nuclear factor-4alpha	9154	3172	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Hepatocyte_nuclear_factor-4alpha and bile_acids regulate human concentrative_nucleoside_transporter-1 gene expression .
21364188	0	congenital_dyserythropoietic_anemia_type_1	23,65	Codanin-1	0,9	congenital dyserythropoietic anemia type 1	Codanin-1	146059	146059	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Codanin-1 mutations in congenital_dyserythropoietic_anemia_type_1 affect HP1 -LCB- alpha -RCB- localization in erythroblasts .
23095116	0	congenital_dyserythropoietic_anemia_type_I	58,100	hemojuvelin	29,40	congenital dyserythropoietic anemia type I	hemojuvelin	146059	148738	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	High levels of soluble serum hemojuvelin in patients with congenital_dyserythropoietic_anemia_type_I .
10069333	0	connectin	73,82	Engrailed	0,9	connectin	Engrailed	38590(Tax:7227)	36240(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Engrailed negatively regulates the expression of cell adhesion molecules connectin and neuroglian_in_embryonic_Drosophila_nervous_system .
1527215	0	connectin	31,40	titin	42,47	connectin	titin	7273	7273	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and elasticity of connectin -LRB- titin -RRB- filaments in skinned frog muscle fibres subjected to partial depolymerization of thick filaments .
2592979	0	connectin	24,33	titin	35,40	connectin	titin	7273	7273	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunochemical study of connectin -LRB- titin -RRB- in neuromuscular_diseases using a monoclonal antibody : connectin is degraded extensively in Duchenne_muscular_dystrophy .
17197570	0	connective_tissue_growth_factor	62,93	ALK-5	0,5	connective tissue growth factor	ALK-5	14219(Tax:10090)	21812(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	ALK-5 mediates endogenous and TGF-beta1-induced expression of connective_tissue_growth_factor in embryonic lung .
12819040	0	connective_tissue_growth_factor	23,54	Angiotensin_II	0,14	connective tissue growth factor	Angiotensin II	64032(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces connective_tissue_growth_factor gene expression via calcineurin-dependent pathways .
14578193	0	connective_tissue_growth_factor	25,56	Angiotensin_II	0,14	connective tissue growth factor	Angiotensin II	64032(Tax:10116)	24179(Tax:10116)	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Angiotensin_II increases connective_tissue_growth_factor in the kidney .
19667256	0	connective_tissue_growth_factor	23,54	Angiotensin_II	0,14	connective tissue growth factor	Angiotensin II	64032(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces connective_tissue_growth_factor and collagen I expression via transforming growth factor-beta-dependent and - independent Smad pathways : the role of Smad3 .
11577177	0	connective_tissue_growth_factor	24,55	CCN2	57,61	connective tissue growth factor	CCN2	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Steroidal regulation of connective_tissue_growth_factor -LRB- CCN2 ; CTGF -RRB- synthesis in the mouse uterus .
15047749	0	connective_tissue_growth_factor	14,45	CCN2	47,51	connective tissue growth factor	CCN2	1490	1490	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of connective_tissue_growth_factor -LRB- CCN2 -RRB- in desmoplastic_small_round_cell_tumour .
15855807	0	connective_tissue_growth_factor	18,49	CCN2	51,55	connective tissue growth factor	CCN2	1490	1490	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	TGF-beta1-induced connective_tissue_growth_factor -LRB- CCN2 -RRB- expression in human renal proximal tubule epithelial cells requires Ras/MEK/ERK and Smad signalling .
19280452	0	connective_tissue_growth_factor	31,62	CCN2	64,68	connective tissue growth factor	CCN2	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Ethanol-mediated expression of connective_tissue_growth_factor -LRB- CCN2 -RRB- in mouse pancreatic_stellate_cells .
24413988	0	connective_tissue_growth_factor	81,112	CCN2	75,79	connective tissue growth factor	CCN2	1490	1490	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	BMP9 inhibits the bone metastasis of breast_cancer cells by downregulating CCN2 -LRB- connective_tissue_growth_factor , CTGF -RRB- expression .
24882759	0	connective_tissue_growth_factor	58,89	CCN2	91,95	connective tissue growth factor	CCN2	1490	1490	Gene	Gene	transfer|nmod|START_ENTITY transfer|appos|END_ENTITY	Exosomes mediate intercellular transfer of pro-fibrogenic connective_tissue_growth_factor -LRB- CCN2 -RRB- between hepatic stellate cells , the principal fibrotic cells in the liver .
10595311	0	connective_tissue_growth_factor	36,67	CTGF	69,73	connective tissue growth factor	CTGF	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of connective_tissue_growth_factor -LRB- CTGF -RRB- in the mouse embryo between days 7.5 and 14.5 of gestation .
11148599	0	connective_tissue_growth_factor	14,45	CTGF	47,51	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of connective_tissue_growth_factor -LRB- CTGF -RRB- mRNA in plaques of human anterior_subcapsular_cataracts and membranes of posterior capsule opacification .
15262182	0	connective_tissue_growth_factor	13,44	CTGF	46,50	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of connective_tissue_growth_factor -LRB- CTGF -RRB- in human endothelial cells by lysophosphatidic_acid , sphingosine-1-phosphate , and platelets .
16828074	0	connective_tissue_growth_factor	8,39	CTGF	41,45	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of connective_tissue_growth_factor -LRB- CTGF -RRB- module 4 in regulating epithelial mesenchymal transition -LRB- EMT -RRB- in HK-2 cells .
16937320	0	connective_tissue_growth_factor	17,48	CTGF	50,54	connective tissue growth factor	CTGF	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Taurine promotes connective_tissue_growth_factor -LRB- CTGF -RRB- expression in osteoblasts through the ERK signal pathway .
18586263	0	connective_tissue_growth_factor	39,70	CTGF	72,76	connective tissue growth factor	CTGF	64032(Tax:10116)	64032(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The Kruppel-like factor KLF15 inhibits connective_tissue_growth_factor -LRB- CTGF -RRB- expression in cardiac fibroblasts .
18586434	0	connective_tissue_growth_factor	15,46	CTGF	48,52	connective tissue growth factor	CTGF	281103(Tax:9913)	281103(Tax:9913)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of connective_tissue_growth_factor -LRB- CTGF -RRB- in insulin-like_growth_factor-I -LRB- IGF1 -RRB- stimulation of proliferation of a bovine mammary epithelial cell line .
18829614	0	connective_tissue_growth_factor	14,45	CTGF	47,51	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of connective_tissue_growth_factor -LRB- CTGF -RRB- by hepatocyte_growth_factor in human tubular epithelial cells .
21466783	0	connective_tissue_growth_factor	83,114	CTGF	116,120	connective tissue growth factor	CTGF	64032(Tax:10116)	64032(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Oral glucosamine increases expression of transforming_growth_factor_b1 -LRB- TGFb1 -RRB- and connective_tissue_growth_factor -LRB- CTGF -RRB- mRNA in rat cartilage and kidney : implications for human efficacy and toxicity .
22045431	0	connective_tissue_growth_factor	26,57	CTGF	59,63	connective tissue growth factor	CTGF	14219(Tax:10090)	14219(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A polymorphism within the connective_tissue_growth_factor -LRB- CTGF -RRB- gene has no effect on non-invasive markers of beta-cell area and risk of type 2 diabetes .
24275091	0	connective_tissue_growth_factor	83,114	CTGF	77,81	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Dual inhibition of Src family kinases and Aurora kinases by SU6656 modulates CTGF -LRB- connective_tissue_growth_factor -RRB- expression in an ERK-dependent manner .
25356109	0	connective_tissue_growth_factor	11,42	CTGF	44,48	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of connective_tissue_growth_factor -LRB- CTGF -RRB- gene silencing on the radiosensitivity of glioblastoma .
25727552	0	connective_tissue_growth_factor	43,74	CTGF	76,80	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The effect of 595 nm pulsed dye laser on connective_tissue_growth_factor -LRB- CTGF -RRB- expression in cultured keloid fibroblasts .
25847009	0	connective_tissue_growth_factor	23,54	CTGF	56,60	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Tumoural expression of connective_tissue_growth_factor -LRB- CTGF -RRB- impacts on survival in patients diagnosed with hepatocellular_carcinoma -LRB- HCC -RRB- .
9168990	0	connective_tissue_growth_factor	146,177	CTGF	179,183	connective tissue growth factor	CTGF	1490	1490	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective_tissue_growth_factor -LRB- CTGF -RRB- mRNA .
25121739	0	connective_tissue_growth_factor	15,46	CXCL12	0,6	connective tissue growth factor	CXCL12	1490	6387	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	CXCL12 induces connective_tissue_growth_factor expression in human lung fibroblasts through the Rac1/ERK , JNK , and AP-1 pathways .
21454550	0	connective_tissue_growth_factor	23,54	Decorin	0,7	connective tissue growth factor	Decorin	1490	1634	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Decorin interacts with connective_tissue_growth_factor -LRB- CTGF -RRB- / CCN2 by LRR12 inhibiting its biological activity .
19111553	0	connective_tissue_growth_factor	21,52	Endothelin-1	0,12	connective tissue growth factor	Endothelin-1	1490	1906	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Endothelin-1 induces connective_tissue_growth_factor expression in cardiomyocytes .
24486572	0	connective_tissue_growth_factor	21,52	Endothelin-1	0,12	connective tissue growth factor	Endothelin-1	1490	1906	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Endothelin-1 induces connective_tissue_growth_factor expression in human lung fibroblasts by ETAR-dependent JNK/AP -1 pathway .
22539964	0	connective_tissue_growth_factor	23,54	Ets-1	0,5	connective tissue growth factor	Ets-1	1490	2113	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Ets-1 is essential for connective_tissue_growth_factor -LRB- CTGF/CCN2 -RRB- induction by TGF-b1 in osteoblasts .
21804025	0	connective_tissue_growth_factor	14,45	IL-13	0,5	connective tissue growth factor	IL-13	64032(Tax:10116)	116553(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-13 induces connective_tissue_growth_factor in rat hepatic stellate cells via TGF-b-independent Smad signaling .
12496395	0	connective_tissue_growth_factor	55,86	IL-15	98,103	connective tissue growth factor	IL-15	1490	3600	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Human gamma delta-T lymphocytes express and synthesize connective_tissue_growth_factor : effect of IL-15 and TGF-beta_1 and comparison with alpha beta-T lymphocytes .
11967989	0	connective_tissue_growth_factor	24,55	Interleukin-4	0,13	connective tissue growth factor	Interleukin-4	1490	3565	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-4 regulates connective_tissue_growth_factor expression in human lung fibroblasts .
16294326	0	connective_tissue_growth_factor	88,119	JNK	70,73	connective tissue growth factor	JNK	64032(Tax:10116)	116554(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Microarray and phosphokinase screenings leading to studies on ERK and JNK regulation of connective_tissue_growth_factor expression by angiotensin_II 1a and bradykinin B2 receptors in Rat1 fibroblasts .
18586263	0	connective_tissue_growth_factor	39,70	KLF15	24,29	connective tissue growth factor	KLF15	64032(Tax:10116)	85497(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	The Kruppel-like factor KLF15 inhibits connective_tissue_growth_factor -LRB- CTGF -RRB- expression in cardiac fibroblasts .
22212430	0	connective_tissue_growth_factor	17,48	PAR-1	104,109	connective tissue growth factor	PAR-1	64032(Tax:10116)	25439(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY cells|dep|expression cells|nmod|END_ENTITY	Thrombin induced connective_tissue_growth_factor expression in rat vascular smooth muscle cells via the PAR-1 / JNK/AP -1 pathway .
11590167	0	connective_tissue_growth_factor	98,129	Peroxisome_proliferator-activated_receptor_gamma	0,48	connective tissue growth factor	Peroxisome proliferator-activated receptor gamma	1490	5468	Gene	Gene	expression|compound|START_ENTITY transforming|dobj|expression inhibits|xcomp|transforming inhibits|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma inhibits transforming growth factor beta-induced connective_tissue_growth_factor expression in human aortic smooth muscle cells by interfering with Smad3 .
19620052	0	connective_tissue_growth_factor	100,131	Peroxisome_proliferator-activated_receptor_gamma	1,49	connective tissue growth factor	Peroxisome proliferator-activated receptor gamma	64032(Tax:10116)	25664(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	-LSB- Peroxisome_proliferator-activated_receptor_gamma inhibits transforming_growth_factor_beta1-induced connective_tissue_growth_factor expression in rat hepatic stellate cells -RSB- .
17133596	0	connective_tissue_growth_factor	32,63	SPARC	0,5	connective tissue growth factor	SPARC	1490	6678	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	SPARC , an upstream regulator of connective_tissue_growth_factor in response to transforming_growth_factor_beta stimulation .
15144593	0	connective_tissue_growth_factor	45,76	Smad2	92,97	connective tissue growth factor	Smad2	14219(Tax:10090)	17126(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- Transforming_growth_factor_beta_1 modulates connective_tissue_growth_factor expression via Smad2 signaling pathway in podocyte in vitro -RSB- .
19667256	0	connective_tissue_growth_factor	23,54	Smad3	171,176	connective tissue growth factor	Smad3	64032(Tax:10116)	25631(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Angiotensin_II induces connective_tissue_growth_factor and collagen I expression via transforming growth factor-beta-dependent and - independent Smad pathways : the role of Smad3 .
24005672	0	connective_tissue_growth_factor	46,77	Stat3	131,136	connective tissue growth factor	Stat3	1490	6774	Gene	Gene	START_ENTITY|acl:relcl|requires requires|dobj|END_ENTITY	Transforming_growth_factor-b -LRB- TGF-b -RRB- - mediated connective_tissue_growth_factor -LRB- CTGF -RRB- expression in hepatic stellate cells requires Stat3 signaling activation .
21251385	0	connective_tissue_growth_factor	41,72	TGF-b1	12,18	connective tissue growth factor	TGF-b1	64032(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of TGF-b1 on gene expression of connective_tissue_growth_factor in lung fibroblasts -RSB- .
22539964	0	connective_tissue_growth_factor	23,54	TGF-b1	80,86	connective tissue growth factor	TGF-b1	1490	7040	Gene	Gene	START_ENTITY|acl|induction induction|nmod|END_ENTITY	Ets-1 is essential for connective_tissue_growth_factor -LRB- CTGF/CCN2 -RRB- induction by TGF-b1 in osteoblasts .
23824844	0	connective_tissue_growth_factor	77,108	TGF-b1	54,60	connective tissue growth factor	TGF-b1	1490	7040	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|compound|END_ENTITY	Requirement for active glycogen_synthase_kinase-3b in TGF-b1 upregulation of connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- levels in human gingival fibroblasts .
22212430	0	connective_tissue_growth_factor	17,48	Thrombin	0,8	connective tissue growth factor	Thrombin	64032(Tax:10116)	29251(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Thrombin induced connective_tissue_growth_factor expression in rat vascular smooth muscle cells via the PAR-1 / JNK/AP -1 pathway .
17300978	0	connective_tissue_growth_factor	32,63	Transforming_growth_factor-beta	0,31	connective tissue growth factor	Transforming growth factor-beta	1490	7040	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Transforming_growth_factor-beta / connective_tissue_growth_factor axis in the kidney .
18287089	0	connective_tissue_growth_factor	55,86	Transforming_growth_factor-beta1	0,32	connective tissue growth factor	Transforming growth factor-beta1	1490	7040	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 -LRB- TGFbeta1 -RRB- stimulates connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- expression in human gingival fibroblasts through a RhoA-independent , Rac1/Cdc42-dependent mechanism : statins with forskolin block TGFbeta1-induced CCN2/CTGF expression .
23727026	0	connective_tissue_growth_factor	51,82	Transforming_growth_factor_b	0,28	connective tissue growth factor	Transforming growth factor b	1490	7040	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor_b induces expression of connective_tissue_growth_factor in hepatic progenitor cells through Smad independent signaling .
11018037	0	connective_tissue_growth_factor	57,88	Vascular_endothelial_growth_factor	0,34	connective tissue growth factor	Vascular endothelial growth factor	281103(Tax:9913)	281572(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces expression of connective_tissue_growth_factor via KDR , Flt1 , and phosphatidylinositol 3-kinase-akt-dependent pathways in retinal_vascular_cells .
14583661	0	connective_tissue_growth_factor	8,39	angiotensin_II	108,122	connective tissue growth factor	angiotensin II	1490	183	Gene	Gene	Role|nmod|START_ENTITY Role|acl|induced induced|nmod|END_ENTITY	Role of connective_tissue_growth_factor in mediating hypertrophy of human proximal tubular cells induced by angiotensin_II .
18319604	0	connective_tissue_growth_factor	31,62	angiotensin_II	66,80	connective tissue growth factor	angiotensin II	14219(Tax:10090)	183	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	SGK1-dependent upregulation of connective_tissue_growth_factor by angiotensin_II .
19277979	0	connective_tissue_growth_factor	8,39	basic_fibroblast_growth_factor	65,95	connective tissue growth factor	basic fibroblast growth factor	14219(Tax:10090)	14173(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of connective_tissue_growth_factor and its interaction with basic_fibroblast_growth_factor and macrophage_chemoattractant_protein-1 in skin fibrosis .
20117462	0	connective_tissue_growth_factor	13,44	connexin_43	55,66	connective tissue growth factor	connexin 43	1490	2697	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Rac1-induced connective_tissue_growth_factor regulates connexin_43 and N-cadherin expression in atrial_fibrillation .
23824844	0	connective_tissue_growth_factor	77,108	glycogen_synthase_kinase-3b	23,50	connective tissue growth factor	glycogen synthase kinase-3b	1490	2932	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Requirement for active glycogen_synthase_kinase-3b in TGF-b1 upregulation of connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- levels in human gingival fibroblasts .
18829614	0	connective_tissue_growth_factor	14,45	hepatocyte_growth_factor	56,80	connective tissue growth factor	hepatocyte growth factor	1490	3082	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of connective_tissue_growth_factor -LRB- CTGF -RRB- by hepatocyte_growth_factor in human tubular epithelial cells .
23139271	0	connective_tissue_growth_factor	10,41	protein_kinase	45,59	connective tissue growth factor	protein kinase	1490	1022	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of connective_tissue_growth_factor on protein_kinase expression and activity in human corneal fibroblasts .
18922980	0	connective_tissue_growth_factor	31,62	sphingosine-1-phosphate_receptor_2	99,133	connective tissue growth factor	sphingosine-1-phosphate receptor 2	1490	9294	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of antiproliferative connective_tissue_growth_factor expression in Wilms ' _ tumor cells by sphingosine-1-phosphate_receptor_2 .
25601519	0	connective_tissue_growth_factor	47,78	sphingosine_1-phosphate_receptor_5	106,140	connective tissue growth factor	sphingosine 1-phosphate receptor 5	1490	53637	Gene	Gene	START_ENTITY|acl:relcl|requires requires|dobj|END_ENTITY	Transforming_growth_factor_b2 -LRB- TGF-b2 -RRB- - induced connective_tissue_growth_factor -LRB- CTGF -RRB- expression requires sphingosine_1-phosphate_receptor_5 -LRB- S1P5 -RRB- in human mesangial cells .
10809757	0	connective_tissue_growth_factor	56,87	transforming_growth_factor-beta	91,122	connective tissue growth factor	transforming growth factor-beta	1490	7040	Gene	Gene	induction|nmod|START_ENTITY suppresses|dobj|induction suppresses|nmod|END_ENTITY	Tumor_necrosis factor alpha suppresses the induction of connective_tissue_growth_factor by transforming_growth_factor-beta in normal and scleroderma fibroblasts .
11673871	0	connective_tissue_growth_factor	77,108	transforming_growth_factor-beta	30,61	connective tissue growth factor	transforming growth factor-beta	1490	7040	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression stimulation|amod|END_ENTITY	Signaling events required for transforming_growth_factor-beta stimulation of connective_tissue_growth_factor expression by cultured human lung fibroblasts .
16217483	0	connective_tissue_growth_factor	45,76	transforming_growth_factor-beta	94,125	connective tissue growth factor	transforming growth factor-beta	1490	7040	Gene	Gene	expression|compound|START_ENTITY increased|dobj|expression increased|nmod|stimulation stimulation|amod|END_ENTITY	Hypertrophic_scar fibroblasts have increased connective_tissue_growth_factor expression after transforming_growth_factor-beta stimulation .
17657819	0	connective_tissue_growth_factor	91,122	transforming_growth_factor-beta	14,45	connective tissue growth factor	transforming growth factor-beta	1490	7040	Gene	Gene	expression|compound|START_ENTITY signaling|nmod|expression END_ENTITY|parataxis|signaling	Profibrogenic transforming_growth_factor-beta / activin_receptor-like_kinase_5 signaling via connective_tissue_growth_factor expression in hepatocytes .
12475893	0	connective_tissue_growth_factor	94,125	transforming_growth_factor-beta1	37,69	connective tissue growth factor	transforming growth factor-beta1	14219(Tax:10090)	21803(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY attenuation|nmod|induction attenuation|amod|through through|amod|END_ENTITY	Hepatocyte_growth_factor counteracts transforming_growth_factor-beta1 , through attenuation of connective_tissue_growth_factor induction , and prevents renal fibrogenesis in 5/6 nephrectomized mice .
12760970	0	connective_tissue_growth_factor	49,80	transforming_growth_factor-beta1	92,124	connective tissue growth factor	transforming growth factor-beta1	1490	7040	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	C-Jun-NH2-terminal kinase mediates expression of connective_tissue_growth_factor induced by transforming_growth_factor-beta1 in human lung fibroblasts .
19210343	0	connective_tissue_growth_factor	64,95	transforming_growth_factor-beta1	10,42	connective tissue growth factor	transforming growth factor-beta1	1490	7040	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of transforming_growth_factor-beta1 on expression of the connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- gene in normal human gingival fibroblasts and periodontal ligament cells .
19466435	0	connective_tissue_growth_factor	118,149	transforming_growth_factor-beta1	72,104	connective tissue growth factor	transforming growth factor-beta1	1490	7040	Gene	Gene	matrix|compound|START_ENTITY induction|nmod|matrix induction|amod|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-gamma inhibits transforming_growth_factor-beta1 induction of connective_tissue_growth_factor and extracellular matrix in hypertrophic_scar_fibroblasts in vitro .
24224514	0	connective_tissue_growth_factor	36,67	transforming_growth_factor-beta1	69,101	connective tissue growth factor	transforming growth factor-beta1	64032(Tax:10116)	59086(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|amod|END_ENTITY	Immunohistochemical localization of connective_tissue_growth_factor , transforming_growth_factor-beta1 and phosphorylated-smad2 / 3 in the developing periodontium of rats .
16838391	0	connective_tissue_growth_factor	29,60	transforming_growth_factor_beta	64,95	connective tissue growth factor	transforming growth factor beta	1490	7040	Gene	Gene	START_ENTITY|nmod|necrosis necrosis|compound|END_ENTITY	Expression and regulation of connective_tissue_growth_factor by transforming_growth_factor_beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn 's _ disease .
17133596	0	connective_tissue_growth_factor	32,63	transforming_growth_factor_beta	79,110	connective tissue growth factor	transforming growth factor beta	1490	7040	Gene	Gene	START_ENTITY|nmod|response response|nmod|stimulation stimulation|compound|END_ENTITY	SPARC , an upstream regulator of connective_tissue_growth_factor in response to transforming_growth_factor_beta stimulation .
19821534	0	connective_tissue_growth_factor	19,50	transforming_growth_factor_beta	68,99	connective tissue growth factor	transforming growth factor beta	1490	7040	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Down-regulation of connective_tissue_growth_factor by inhibition of transforming_growth_factor_beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular_carcinoma .
9052988	0	connective_tissue_growth_factor	88,119	transforming_growth_factor_beta	8,39	connective tissue growth factor	transforming growth factor beta	1490	7040	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene controls|dobj|expression controls|nsubj|element element|compound|END_ENTITY	A novel transforming_growth_factor_beta response element controls the expression of the connective_tissue_growth_factor gene .
11509128	0	connective_tissue_growth_factor	61,92	tumor_necrosis_factor_alpha	12,39	connective tissue growth factor	tumor necrosis factor alpha	64032(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of tumor_necrosis_factor_alpha on the expression of connective_tissue_growth_factor in hepatic stellate cells -RSB- .
12114504	0	connective_tissue_growth_factor	33,64	vascular_endothelial_growth_factor	103,137	connective tissue growth factor	vascular endothelial growth factor	14219(Tax:10090)	22339(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Matrix metalloproteinases cleave connective_tissue_growth_factor and reactivate angiogenic activity of vascular_endothelial_growth_factor 165 .
16432171	0	connective_tissue_growth_factor	83,114	vascular_endothelial_growth_factor	130,164	connective tissue growth factor	vascular endothelial growth factor	1490	7422	Gene	Gene	induction|nmod|START_ENTITY inhibits|dobj|induction inhibits|nmod|END_ENTITY	Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective_tissue_growth_factor -LRB- CTGF/CCN2 -RRB- by vascular_endothelial_growth_factor in human endothelial cells .
17355828	0	connective_tissue_growth_factor	46,77	vascular_endothelial_growth_factor	99,133	connective tissue growth factor	vascular endothelial growth factor	1490	7422	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Inhibition effect of small interfering RNA of connective_tissue_growth_factor on the expression of vascular_endothelial_growth_factor and connective_tissue_growth_factor in cultured human peritoneal mesothelial cells .
15757815	0	connexin	8,16	ectodermal_dysplasia	54,74	connexin	ectodermal dysplasia	100128922	1896	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Bigenic connexin mutations in a patient with hidrotic ectodermal_dysplasia .
15479191	0	connexin-26	47,58	GJB2	60,64	connexin-26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High prevalence of V37I genetic variant in the connexin-26 -LRB- GJB2 -RRB- gene among non-syndromic_hearing-impaired and control Thai individuals .
17313762	0	connexin-26	20,31	GJB2	33,37	connexin-26	GJB2	2706	2706	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	-LSB- High prevalence of connexin-26 -LRB- GJB2 -RRB- mutation in cochlear implant recipients -RSB- .
17695503	0	connexin-26	63,74	connexin-30	24,35	connexin-26	connexin-30	2706	10804	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head_and_neck_cancer .
17695503	0	connexin-30	24,35	connexin-26	63,74	connexin-30	connexin-26	10804	2706	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Decreased expression of connexin-30 and aberrant expression of connexin-26 in human head_and_neck_cancer .
25080381	0	connexin-40	23,34	Neuregulin-1	0,12	connexin-40	Neuregulin-1	14613(Tax:10090)	211323(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Neuregulin-1 increases connexin-40 and connexin-45 expression in embryonic stem cell-derived cardiomyocytes .
7776963	0	connexin-43	42,53	Basic_fibroblast_growth_factor	0,30	connexin-43	Basic fibroblast growth factor	2697	2247	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor stimulates connexin-43 expression and intercellular communication of cardiac fibroblasts .
11684338	0	connexin-43	39,50	Epidermal_growth_factor	0,23	connexin-43	Epidermal growth factor	24392(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Epidermal_growth_factor down-regulates connexin-43 expression in cultured rat cortical astrocytes .
11014245	0	connexin-43	25,36	Growth_hormone	0,14	connexin-43	Growth hormone	24392(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Growth_hormone increases connexin-43 expression in the cerebral cortex and hypothalamus .
12064598	0	connexin-43	75,86	Protein_kinase_C-epsilon	0,24	connexin-43	Protein kinase C-epsilon	2697	5581	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Protein_kinase_C-epsilon mediates phorbol_ester-induced phosphorylation of connexin-43 .
9543137	0	connexin-43	9,20	c-Jun	82,87	connexin-43	c-Jun	2697	3725	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|amod|END_ENTITY	Elevated connexin-43 expression in term human myometrium correlates with elevated c-Jun expression and is independent of myometrial estrogen receptors .
10790215	0	connexin31	93,103	GJB3	105,109	connexin31	GJB3	2707	2707	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of seven novel SNPS -LRB- five nucleotide and two amino_acid substitutions -RRB- in the connexin31 -LRB- GJB3 -RRB- gene .
1319348	0	connexin32	91,101	connexin43	144,154	connexin32	connexin43	14618(Tax:10090)	14618(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43 .
17122196	0	connexin40	18,28	tumor_necrosis_factor	137,158	connexin40	tumor necrosis factor	14613(Tax:10090)	21926(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of connexin40 and increased prevalence of atrial_arrhythmias in transgenic_mice with cardiac-restricted overexpression of tumor_necrosis_factor .
17624368	0	connexin43	34,44	Angiotensin_II	0,14	connexin43	Angiotensin II	2697	183	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Angiotensin_II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits .
12068002	0	connexin43	99,109	Ciliary_neurotrophic_factor	0,27	connexin43	Ciliary neurotrophic factor	2697	1270	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- in combination with its soluble receptor -LRB- CNTFRalpha -RRB- increases connexin43 expression and suppresses growth of C6_glioma cells .
16449318	0	connexin43	39,49	Connexin31	0,10	connexin43	Connexin31	14609(Tax:10090)	14620(Tax:10090)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	Connexin31 can not functionally replace connexin43 during cardiac morphogenesis in mice .
23460926	0	connexin43	46,56	Connexin43	0,10	connexin43	Connexin43	100518636	100518636	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Connexin43 hemichannel-mediated regulation of connexin43 .
17624368	0	connexin43	34,44	ERK	60,63	connexin43	ERK	2697	5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Angiotensin_II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits .
20375327	0	connexin43	43,53	GJA1	55,59	connexin43	GJA1	2697	2697	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of gap junction protein connexin43 -LRB- GJA1 -RRB- in the human retina and optic nerve .
9184001	0	connexin43	24,34	GJA1	41,45	connexin43	GJA1	2697	2697	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human connexin43 gene , GJA1 , to chromosome 6q22 .3 .
24048574	0	connexin43	119,129	Gja1	113,117	connexin43	Gja1	14609(Tax:10090)	14609(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Decidual angiogenesis and placental orientation are altered in mice heterozygous for a dominant loss-of-function Gja1 -LRB- connexin43 -RRB- mutation .
16931598	0	connexin43	40,50	Nedd4	25,30	connexin43	Nedd4	2697	4734	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process .
23201262	0	connexin43	52,62	Sp1	77,80	connexin43	Sp1	2697	6667	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Role of Rev-erba domains for transactivation of the connexin43 promoter with Sp1 .
17956757	0	connexin43	19,29	Src	41,44	connexin43	Src	2697	6714	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Phosphorylation of connexin43 induced by Src : regulation of gap junctional communication between transformed cells .
25560303	0	connexin43	20,30	TGF-b1	0,6	connexin43	TGF-b1	2697	7040	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	TGF-b1 up-regulates connexin43 expression : a potential mechanism for human trophoblast cell differentiation .
11824477	0	connexin43	37,47	TGF-beta1	0,9	connexin43	TGF-beta1	281193(Tax:9913)	282089(Tax:9913)	Gene	Gene	accumulation|nmod|START_ENTITY induces|dobj|accumulation induces|nsubj|END_ENTITY	TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in endothelial cells .
12538692	0	connexin43	32,42	TNF-alpha	0,9	connexin43	TNF-alpha	2697	7124	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses .
1319348	0	connexin43	144,154	connexin32	91,101	connexin43	connexin32	14618(Tax:10090)	14618(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43 .
16463142	0	connexin45	80,90	ZO-1	17,21	connexin45	ZO-1	10052	7082	Gene	Gene	mutants|amod|START_ENTITY partitioning|nmod|mutants membrane|acl|partitioning correlates|nmod|membrane correlates|nsubj|Association Association|nmod|END_ENTITY	Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants .
15448617	0	connexin46	8,18	GJA3	20,24	connexin46	GJA3	2700	2700	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A novel connexin46 -LRB- GJA3 -RRB- mutation in autosomal dominant congenital nuclear pulverulent cataract .
21552498	0	connexin46	30,40	GJA3	24,28	connexin46	GJA3	2700	2700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel mutation in the GJA3 -LRB- connexin46 -RRB- gene is associated with autosomal dominant congenital_nuclear_cataract in a Chinese family .
22312188	0	connexin46	39,49	GJA3	51,55	connexin46	GJA3	2700	2700	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Coralliform cataract caused by a novel connexin46 -LRB- GJA3 -RRB- mutation in a Chinese family .
15467523	0	connexin46	32,42	protein_kinase_Cgamma	80,101	connexin46	protein kinase Cgamma	2700	5582	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential phosphorylation of connexin46 and connexin50 by H2O2 activation of protein_kinase_Cgamma .
8654111	0	connexin49	27,37	MP70	60,64	connexin49	MP70	100170231(Tax:9940)	74140(Tax:10090)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of sheep connexin49 and its identity with MP70 .
9497259	0	connexin50	33,43	GJA8	50,54	connexin50	GJA8	2703	2703	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A missense mutation in the human connexin50 gene -LRB- GJA8 -RRB- underlies autosomal dominant `` zonular pulverulent '' cataract , on chromosome 1q .
24220509	0	connexin_26	23,34	CO2	0,3	connexin 26	CO2	2706	717	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	CO2 directly modulates connexin_26 by formation of carbamate bridges between subunits .
25263585	0	connexin_26	25,36	Dynamin_2	0,9	connexin 26	Dynamin 2	2706	1785	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dynamin_2 interacts with connexin_26 to regulate its degradation and function in gap junction formation .
10204859	0	connexin_26	87,98	GJB2	100,104	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allele specific oligonucleotide analysis of the common deafness mutation 35delG in the connexin_26 -LRB- GJB2 -RRB- gene .
10607953	0	connexin_26	23,34	GJB2	41,45	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations in the connexin_26 gene -LRB- GJB2 -RRB- responsible for childhood deafness in the Japanese population .
10633133	0	connexin_26	10,21	GJB2	28,32	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prevalent connexin_26 gene -LRB- GJB2 -RRB- mutations in Japanese .
10874298	0	connexin_26	31,42	GJB2	25,29	connexin 26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation analysis of the GJB2 -LRB- connexin_26 -RRB- gene by DGGE in Greek patients with sensorineural_deafness .
10982180	0	connexin_26	76,87	GJB2	70,74	connexin 26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular basis of childhood_deafness resulting from mutations in the GJB2 -LRB- connexin_26 -RRB- gene .
11162081	0	connexin_26	43,54	GJB2	37,41	connexin 26	GJB2	2706	2706	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	PCR test for diagnosis of the common GJB2 -LRB- connexin_26 -RRB- 35delG mutation on dried blood spots and determination of the carrier frequency in France .
11698809	0	connexin_26	6,17	GJB2	0,4	connexin 26	GJB2	2706	2706	Gene	Gene	mutations|amod|START_ENTITY mutations|amod|END_ENTITY	GJB2 -LRB- connexin_26 -RRB- mutations and childhood deafness in Thailand .
12081719	0	connexin_26	47,58	GJB2	41,45	connexin 26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Deafness resulting from mutations in the GJB2 -LRB- connexin_26 -RRB- gene in Brazilian patients .
12792423	0	connexin_26	25,36	GJB2	38,42	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation spectrum of the connexin_26 -LRB- GJB2 -RRB- gene in Taiwanese patients with prelingual_deafness .
12910486	0	connexin_26	97,108	GJB2	110,114	connexin 26	GJB2	2706	2706	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Use of a multiplex PCR/sequencing strategy to detect both connexin_30 -LRB- GJB6 -RRB- 342 kb deletion and connexin_26 -LRB- GJB2 -RRB- mutations in cases of childhood deafness .
14985372	0	connexin_26	43,54	GJB2	37,41	connexin 26	GJB2	2706	2706	Gene	Gene	correlation|appos|START_ENTITY correlation|nmod|END_ENTITY	A genotype-phenotype correlation for GJB2 -LRB- connexin_26 -RRB- deafness .
15700112	0	connexin_26	41,52	GJB2	35,39	connexin 26	GJB2	2706	2706	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	Clinical features of patients with GJB2 -LRB- connexin_26 -RRB- mutations : severity of hearing_loss is correlated with genotypes and protein expression patterns .
15832357	0	connexin_26	6,17	GJB2	0,4	connexin 26	GJB2	2706	2706	Gene	Gene	mutations|appos|START_ENTITY mutations|compound|END_ENTITY	GJB2 -LRB- connexin_26 -RRB- mutations are not a major cause of hearing_loss in the Indonesian population .
15857182	0	connexin_26	27,38	GJB2	45,49	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 35delG mutation in the connexin_26 gene -LRB- GJB2 -RRB- associated with congenital_deafness : European carrier frequencies and evidence for its origin in ancient Greece .
15954104	0	connexin_26	31,42	GJB2	25,29	connexin 26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutation analysis of the GJB2 -LRB- connexin_26 -RRB- gene in Egypt .
19491791	0	connexin_26	106,117	GJB2	100,104	connexin 26	GJB2	2706	2706	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Cochlear implantation in a child with congenital sensorineural_deafness due to 35_DELG mutation in GJB2 -LRB- connexin_26 -RRB- gene -RSB- .
19707039	0	connexin_26	23,34	GJB2	36,40	connexin 26	GJB2	2706	2706	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	High prevalence of the connexin_26 -LRB- GJB2 -RRB- mutation in Chinese_cochlear implant recipients .
19902103	0	connexin_26	101,112	GJB2	119,123	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ultrastructure of the hair in genetic prelingual_deafness associated with the 35delG mutation in the connexin_26 gene -LRB- GJB2 -RRB- .
20846357	0	connexin_26	24,35	GJB2	42,46	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|appos|END_ENTITY	A novel mutation in the connexin_26 gene -LRB- GJB2 -RRB- in a child with clinical and histological features of keratitis-ichthyosis-deafness -LRB- KID -RRB- syndrome .
22567861	0	connexin_26	16,27	GJB2	29,33	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Changes in the connexin_26 -LRB- GJB2 -RRB- gene in Russian patients with hearing_disorders : results of long-term molecular diagnostics of hereditary_nonsyndromic_deafness -RSB- .
26444850	0	connexin_26	13,24	GJB2	26,30	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations of connexin_26 -LRB- GJB2 -RRB- gene in a Chinese keratitis-ichthyosis-deafness_syndrome patient with squamous_cell_carcinoma .
9529365	0	connexin_26	23,34	GJB2	41,45	connexin 26	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations in the connexin_26 gene -LRB- GJB2 -RRB- that cause autosomal recessive -LRB- DFNB1 -RRB- hearing_loss .
15468313	0	connexin_32	103,114	GJB1	97,101	connexin 32	GJB1	2705	2705	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	X-linked_Charcot-Marie-Tooth_disease : phenotypic expression of a novel mutation Ile127Ser in the GJB1 -LRB- connexin_32 -RRB- gene .
12363395	0	connexin_36	27,38	CX36	45,49	connexin 36	CX36	57369	57369	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the connexin_36 gene -LRB- CX36 -RRB- and exclusion of the coding sequence as a candidate region for catatonic_schizophrenia in a large pedigree .
15778849	0	connexin_39	22,33	rCx39	35,40	connexin 39	rCx39	266707(Tax:10116)	266707(Tax:10116)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Expression of the rat connexin_39 -LRB- rCx39 -RRB- gene in myoblasts and myotubes in developing and regenerating skeletal muscles : an in situ hybridization study .
23262036	0	connexin_43	61,72	CXCL12	10,16	connexin 43	CXCL12	2697	6387	Gene	Gene	phosphorylate|dobj|START_ENTITY activates|xcomp|phosphorylate activates|nsubj|END_ENTITY	Exogenous CXCL12 activates protein kinase C to phosphorylate connexin_43 for gap junctional intercellular communication among confluent breast_cancer cells .
17895291	0	connexin_43	42,53	Corticotropin-releasing_hormone	0,31	connexin 43	Corticotropin-releasing hormone	2697	1392	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Corticotropin-releasing_hormone activates connexin_43 via activator_protein-1 transcription factor in human myometrial smooth muscle cells .
22325386	0	connexin_43	35,46	Cx43	48,52	connexin 43	Cx43	24392(Tax:10116)	24392(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prenatal retinoic_acid upregulates connexin_43 -LRB- Cx43 -RRB- gene expression in pulmonary_hypoplasia in the nitrofen-induced congenital_diaphragmatic_hernia rat model .
23685568	0	connexin_43	100,111	Cx43	113,117	connexin 43	Cx43	2697	2697	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Short-term cultivation of porcine cumulus cells influences the cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- and connexin_43 -LRB- Cx43 -RRB- protein expression -- a real-time cell proliferation approach .
12080012	0	connexin_43	47,58	Epidermal_growth_factor	0,23	connexin 43	Epidermal growth factor	14609(Tax:10090)	13645(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein enhances|dobj|expression enhances|nsubj|END_ENTITY	Epidermal_growth_factor enhances expression of connexin_43 protein in cultured porcine preantral follicles .
22611165	0	connexin_43	34,45	Epidermal_growth_factor	0,23	connexin 43	Epidermal growth factor	2697	1950	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Epidermal_growth_factor regulates connexin_43 in the human epididymis : role of gap junctions in azoospermia .
10976987	0	connexin_43	57,68	Interleukin-1beta	0,17	connexin 43	Interleukin-1beta	100008935(Tax:9986)	100008990(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-1beta increases the functional expression of connexin_43 in articular chondrocytes : evidence for a Ca2 + - dependent mechanism .
19781809	0	connexin_43	25,36	TGF-beta1	0,9	connexin 43	TGF-beta1	24392(Tax:10116)	59086(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	TGF-beta1 down-regulates connexin_43 expression and gap junction intercellular communication in rat hepatic stellate cells .
17895291	0	connexin_43	42,53	activator_protein-1	58,77	connexin 43	activator protein-1	2697	2353	Gene	Gene	START_ENTITY|nmod|factor factor|amod|END_ENTITY	Corticotropin-releasing_hormone activates connexin_43 via activator_protein-1 transcription factor in human myometrial smooth muscle cells .
23229005	0	connexin_43	104,115	androgen_receptor	18,35	connexin 43	androgen receptor	14609(Tax:10090)	11835(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Expression of the androgen_receptor in the testis of mice with a Sertoli cell specific knock-out of the connexin_43 gene -LRB- SCCx43KO -LRB- - / - -RRB- -RRB- .
11463347	0	connexin_43	58,69	angiotensin_II	10,24	connexin 43	angiotensin II	24392(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of angiotensin_II and ethanol on the expression of connexin_43 in WB rat liver epithelial cells .
20117462	0	connexin_43	55,66	connective_tissue_growth_factor	13,44	connexin 43	connective tissue growth factor	2697	1490	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rac1-induced connective_tissue_growth_factor regulates connexin_43 and N-cadherin expression in atrial_fibrillation .
19725064	0	connexin_43	61,72	cortactin	34,43	connexin 43	cortactin	14609(Tax:10090)	13043(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Cortactin/tyrosine-phosphorylated cortactin interaction with connexin_43 in mouse seminiferous tubules .
16885921	0	connexin_46	24,35	GJA3	42,46	connexin 46	GJA3	2700	2700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the connexin_46 gene -LRB- GJA3 -RRB- causes autosomal dominant zonular pulverulent cataract in a Hispanic family .
17615540	0	connexin_46	63,74	GJA3	76,80	connexin 46	GJA3	2700	2700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel `` pearl box '' cataract associated with a mutation in the connexin_46 -LRB- GJA3 -RRB- gene .
17893674	0	connexin_46	24,35	GJA3	37,41	connexin 46	GJA3	2700	2700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the connexin_46 -LRB- GJA3 -RRB- gene associated with autosomal dominant congenital_cataract in an Indian family .
20431721	0	connexin_46	105,116	GJA3	123,127	connexin 46	GJA3	2700	2700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of congenital_cataract in a Chinese family identified a novel missense mutation in the connexin_46 gene -LRB- GJA3 -RRB- .
21647269	0	connexin_46	24,35	GJA3	37,41	connexin 46	GJA3	2700	2700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the connexin_46 -LRB- GJA3 -RRB- gene associated with congenital_cataract in a Chinese pedigree .
16271086	0	connexin_46	56,67	Gja3	69,73	connexin 46	Gja3	79217(Tax:10116)	79217(Tax:10116)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	New genetic model rat for congenital_cataracts due to a connexin_46 -LRB- Gja3 -RRB- mutation .
11702063	0	connexin_46	29,40	PKC-gamma	0,9	connexin 46	PKC-gamma	79217(Tax:10116)	24681(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	PKC-gamma phosphorylation of connexin_46 in the lens cortex .
23592915	0	connexin_46	36,47	gap_junction_alpha_3	49,69	connexin 46	gap junction alpha 3	2700	2700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel insertional mutation in the connexin_46 -LRB- gap_junction_alpha_3 -RRB- gene associated with autosomal dominant congenital_cataract in a Chinese family .
9746435	0	connexin_50	18,29	Cx50	31,35	connexin 50	Cx50	14616(Tax:10090)	14616(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A mutation in the connexin_50 -LRB- Cx50 -RRB- gene is a candidate for the No2 mouse cataract .
18334966	0	connexin_50	8,19	GJA8	21,25	connexin 50	GJA8	2703	2703	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A novel connexin_50 -LRB- GJA8 -RRB- mutation in a Chinese family with a dominant congenital pulverulent nuclear cataract .
20597646	0	connexin_50	24,35	GJA8	42,46	connexin 50	GJA8	2703	2703	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the connexin_50 gene -LRB- GJA8 -RRB- associated with autosomal_dominant_congenital_nuclear_cataract in a Chinese family .
11075820	0	constitutive_active_receptor	56,84	CAR	51,54	constitutive active receptor	CAR	12355(Tax:10090)	12355(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Estrogen activation of the nuclear orphan receptor CAR -LRB- constitutive_active_receptor -RRB- in induction of the mouse Cyp2b10 gene .
20686344	0	constitutive_androstane_receptor	95,127	AMPK	161,165	constitutive androstane receptor	AMPK	65035(Tax:10116)	78975(Tax:10116)	Gene	Gene	manner|amod|START_ENTITY manner|appos|END_ENTITY	5-aminoimidazole-4-carboxamide-1-beta-ribofuranoside -LRB- AICAR -RRB- prevents nuclear translocation of constitutive_androstane_receptor by AMP-activated_protein_kinase -LRB- AMPK -RRB- independent manner .
24180433	0	constitutive_androstane_receptor	133,165	CAR	167,170	constitutive androstane receptor	CAR	9970	9970	Gene	Gene	activator|compound|START_ENTITY activator|appos|END_ENTITY	Mode of action and human relevance analysis for nuclear receptor-mediated liver_toxicity : A case study with phenobarbital as a model constitutive_androstane_receptor -LRB- CAR -RRB- activator .
24675475	0	constitutive_androstane_receptor	121,153	CAR	155,158	constitutive androstane receptor	CAR	12355(Tax:10090)	12355(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive_androstane_receptor -LRB- CAR -RRB- activation plays in their mode of action .
25069801	0	constitutive_androstane_receptor	67,99	CAR	101,104	constitutive androstane receptor	CAR	9970	9970	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Allyl_isothiocyanate -LRB- AITC -RRB- inhibits pregnane_X_receptor -LRB- PXR -RRB- and constitutive_androstane_receptor -LRB- CAR -RRB- activation and protects against acetaminophen - and amiodarone-induced cytotoxicity .
26275810	0	constitutive_androstane_receptor	30,62	CAR	64,67	constitutive androstane receptor	CAR	9970	9970	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Genome-wide analysis of human constitutive_androstane_receptor -LRB- CAR -RRB- transcriptome in wild-type and CAR-knockout HepaRG cells .
16513849	0	constitutive_androstane_receptor	62,94	CYP2B6	35,41	constitutive androstane receptor	CYP2B6	9970	1555	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive_androstane_receptor but not pregnane_X_receptor .
15933212	0	constitutive_androstane_receptor	69,101	CYP2C8	6,12	constitutive androstane receptor	CYP2C8	9970	1558	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive_androstane_receptor , pregnane_X_receptor , glucocorticoid_receptor , and hepatic_nuclear_factor_4alpha .
12130689	0	constitutive_androstane_receptor	59,91	CYP3A4	40,46	constitutive androstane receptor	CYP3A4	9970	1576	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the human CYP3A4 gene by the constitutive_androstane_receptor .
21296199	0	constitutive_androstane_receptor	32,64	Farnesoid_X_receptor	0,20	constitutive androstane receptor	Farnesoid X receptor	9970	9971	Gene	Gene	activity|compound|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	Farnesoid_X_receptor suppresses constitutive_androstane_receptor activity at the multidrug_resistance_protein-4 promoter .
16006237	0	constitutive_androstane_receptor	11,43	MDR1	82,86	constitutive androstane receptor	MDR1	9970	5243	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	A role for constitutive_androstane_receptor in the regulation of human intestinal MDR1 expression .
17888866	0	constitutive_androstane_receptor	48,80	cathepsin_E	24,35	constitutive androstane receptor	cathepsin E	9970	1510	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the human cathepsin_E gene by the constitutive_androstane_receptor .
23934188	0	constitutive_androstane_receptor	22,54	miR-137	0,7	constitutive androstane receptor	miR-137	9970	406928	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	miR-137 regulates the constitutive_androstane_receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells .
18492798	0	constitutive_androstane_receptor	136,168	peripheral_benzodiazepine_receptor	4,38	constitutive androstane receptor	peripheral benzodiazepine receptor	9970	706	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	The peripheral_benzodiazepine_receptor ligand 1 - -LRB- 2-chlorophenyl-methylpropyl -RRB- -3 - isoquinoline-carboxamide is a novel antagonist of human constitutive_androstane_receptor .
11976065	0	constitutively_active_receptor	30,60	CYP2B	67,72	constitutively active receptor	CYP2B	12355(Tax:10090)	13088(Tax:10090)	Gene	Gene	responses|nmod|START_ENTITY responses|dep|END_ENTITY	Species-specific responses of constitutively_active_receptor -LRB- CAR -RRB- - CYP2B coupling : lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost , scup -LRB- Stenotomus chrysops -RRB- .
15459097	0	contactin	11,20	contactin	46,55	contactin	contactin	40553(Tax:7227)	40553(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Drosophila contactin , a homolog of vertebrate contactin , is required for septate junction organization and paracellular barrier function .
15459097	0	contactin	46,55	contactin	11,20	contactin	contactin	40553(Tax:7227)	40553(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Drosophila contactin , a homolog of vertebrate contactin , is required for septate junction organization and paracellular barrier function .
11352571	0	contactin-associated_protein-like_2	10,45	CNTNAP2	52,59	contactin-associated protein-like 2	CNTNAP2	26047	26047	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human contactin-associated_protein-like_2 gene -LRB- CNTNAP2 -RRB- spans over 2 Mb of DNA at chromosome 7q35 .
15106122	0	contactin_4	14,25	CNTN4	27,32	contactin 4	CNTN4	152330	152330	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Disruption of contactin_4 -LRB- CNTN4 -RRB- results in developmental_delay and other features of 3p deletion syndrome .
23736031	0	cop1	43,47	p28	0,3	cop1	p28	64326	9527	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	p28 , a first in class peptide inhibitor of cop1 binding to p53 .
9747031	0	coproporphyrinogen_oxidase	20,46	CPO	48,51	coproporphyrinogen oxidase	CPO	1371	1371	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation of coproporphyrinogen_oxidase -LRB- CPO -RRB- gene in a Japanese family .
9168923	0	coproporphyrinogen_oxidase	80,106	GATA-1	42,48	coproporphyrinogen oxidase	GATA-1	12892(Tax:10090)	14460(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the transcriptional factor GATA-1 in regulation of expression of coproporphyrinogen_oxidase in mouse_erythroleukemia cells .
8593679	0	coproporphyrinogen_oxidase	109,135	HEM13	97,102	coproporphyrinogen oxidase	HEM13	851614(Tax:4932)	851614(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene -LRB- coproporphyrinogen_oxidase -RRB- in Saccharomyces_cerevisiae .
8260628	0	cor15a	54,60	cor15b	21,27	cor15a	cor15b	818854(Tax:3702)	818853(Tax:3702)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Arabidopsis_thaliana cor15b , an apparent homologue of cor15a , is strongly responsive to cold and ABA , but not drought .
8260628	0	cor15b	21,27	cor15a	54,60	cor15b	cor15a	818853(Tax:3702)	818854(Tax:3702)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Arabidopsis_thaliana cor15b , an apparent homologue of cor15a , is strongly responsive to cold and ABA , but not drought .
8809409	0	core-binding_factor	43,62	GM-CSF	14,20	core-binding factor	GM-CSF	10153	1437	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of GM-CSF gene transcription by core-binding_factor .
8824275	0	core-binding_factor_alpha2	46,72	AML1	74,78	core-binding factor alpha2	AML1	12394(Tax:10090)	12394(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Biochemical and biophysical properties of the core-binding_factor_alpha2 -LRB- AML1 -RRB- DNA-binding domain .
12780793	0	core_binding_factor	55,74	c-KIT	27,32	core binding factor	c-KIT	10153	3815	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Incidence and prognosis of c-KIT and FLT3 mutations in core_binding_factor -LRB- CBF -RRB- acute_myeloid_leukaemias .
10671545	0	core_binding_factor_alpha1	114,140	Parathyroid_hormone	0,19	core binding factor alpha1	Parathyroid hormone	367218(Tax:10116)	24694(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Parathyroid_hormone regulation of the rat collagenase-3 promoter by protein_kinase_A-dependent transactivation of core_binding_factor_alpha1 .
10671545	0	core_binding_factor_alpha1	114,140	collagenase-3	42,55	core binding factor alpha1	collagenase-3	367218(Tax:10116)	171052(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|amod|END_ENTITY	Parathyroid_hormone regulation of the rat collagenase-3 promoter by protein_kinase_A-dependent transactivation of core_binding_factor_alpha1 .
8930392	0	corkscrew	94,103	Src64	46,51	corkscrew	Src64	45278(Tax:7227)	48973(Tax:7227)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Signaling by ectopically expressed Drosophila Src64 requires the protein-tyrosine phosphatase corkscrew and the adapter downstream_of_receptor_kinases .
12472658	0	corneodesmosin	52,66	CDSN	73,77	corneodesmosin	CDSN	1041	1041	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Psoriasis is associated with a SNP haplotype of the corneodesmosin gene -LRB- CDSN -RRB- .
15529278	0	corneodesmosin	92,106	CDSN	113,117	corneodesmosin	CDSN	1041	1041	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping of the major psoriasis-susceptibility locus -LRB- PSORS1 -RRB- in a 70-Kb interval around the corneodesmosin gene -LRB- CDSN -RRB- .
22574790	0	corneodesmosin	90,104	CDSN	106,110	corneodesmosin	CDSN	101109128	101109128	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Predictive mutational bioinformatic analysis of variation in the skin and wool associated corneodesmosin -LRB- CDSN -RRB- gene in sheep .
12499356	0	coronin	87,94	Arp2/3	21,27	coronin	Arp2/3	851148(Tax:4932)	851532;853528	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin .
23933558	0	coronin_1	19,28	CD4	42,45	coronin 1	CD4	11151	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Diverging role for coronin_1 in antiviral CD4 + and CD8 + T cell responses .
16027158	0	coronin_1B	19,29	Arp2/3	77,83	coronin 1B	Arp2/3	57175	10097;10096	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of coronin_1B by protein_kinase_C regulates interaction with Arp2/3 and cell motility .
15064355	0	cortactin	22,31	BPGAP1	0,6	cortactin	BPGAP1	2017	23779	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration .
15506981	0	cortactin	59,68	BPGAP1	43,49	cortactin	BPGAP1	2017	23779	Gene	Gene	translocation|compound|START_ENTITY promotes|dobj|translocation promotes|nsubj|END_ENTITY	Filling the GAPs in cell dynamics control : BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration .
21418910	0	cortactin	19,28	CTTN	32,36	cortactin	CTTN	2017	2017	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	-LSB- A pivotal role of cortactin , a CTTN encoding protein , in endocytosis of human colon_cancer -RSB- .
16905744	0	cortactin	43,52	CXCL12	0,6	cortactin	CXCL12	2017	6387	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	CXCL12 induces tyrosine phosphorylation of cortactin , which plays a role in CXC_chemokine_receptor_4-mediated extracellular signal-regulated kinase activation and chemotaxis .
18775315	0	cortactin	23,32	Coronin_1B	0,10	cortactin	Coronin 1B	2017	57175	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Coronin_1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia .
23536706	0	cortactin	29,38	Dock4	8,13	cortactin	Dock4	2017	9732	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation .
18776588	0	cortactin	15,24	EGFR	73,77	cortactin	EGFR	2017	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Association of cortactin , fascin-1 and epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in ovarian_carcinomas : correlation with clinicopathological parameters .
18852256	0	cortactin	21,30	Ezrin	0,5	cortactin	Ezrin	2017	7430	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ezrin interacts with cortactin to form podosomal rosettes in pancreatic_cancer cells .
24867096	0	cortactin	14,23	FBXL5	0,5	cortactin	FBXL5	2017	26234	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric_cancer cell migration .
12913069	0	cortactin	84,93	Fgd1	0,4	cortactin	Fgd1	13043(Tax:10090)	14163(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fgd1 , the Cdc42 GEF responsible for Faciogenital_Dysplasia , directly interacts with cortactin and mAbp1 to modulate cell shape .
18387954	0	cortactin	16,25	PTP1B	0,5	cortactin	PTP1B	2017	5770	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	PTP1B regulates cortactin tyrosine phosphorylation by targeting Tyr446 .
10075710	0	cortactin	77,86	Src	25,28	cortactin	Src	2017	6714	Gene	Gene	exchangers|amod|START_ENTITY phosphorylation|nmod|exchangers kinases|dobj|phosphorylation kinases|nsubj|END_ENTITY	Cell shrinkage regulates Src kinases and induces tyrosine phosphorylation of cortactin , independent of the osmotic regulation of Na + / H + exchangers .
16385081	0	cortactin	17,26	Src	46,49	cortactin	Src	2017	6714	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro .
17606906	0	cortactin	23,32	Src	0,3	cortactin	Src	2017	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Src phosphorylation of cortactin enhances actin assembly .
19038333	0	cortactin	20,29	Src	117,120	cortactin	Src	2017	6714	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|interdependence interdependence|nmod|END_ENTITY	Characterization of cortactin as an in vivo protein_kinase_D substrate : interdependence of sites and potentiation by Src .
23097045	0	cortactin	10,19	Src	0,3	cortactin	Src	2017	6714	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Src binds cortactin through an SH2 domain cystine-mediated linkage .
26043691	0	cortactin	27,36	Src	0,3	cortactin	Src	2017	6714	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|tyrosyl tyrosyl|compound|END_ENTITY	Src tyrosyl phosphorylates cortactin in response to prolactin .
7592885	0	cortactin	7,16	Src	37,40	cortactin	Src	13043(Tax:10090)	20779(Tax:10090)	Gene	Gene	associates|compound|START_ENTITY associates|nmod|domain domain|compound|END_ENTITY	p80/85 cortactin associates with the Src SH2 domain and colocalizes with v-Src in transformed cells .
19725064	0	cortactin	34,43	connexin_43	61,72	cortactin	connexin 43	13043(Tax:10090)	14609(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Cortactin/tyrosine-phosphorylated cortactin interaction with connexin_43 in mouse seminiferous tubules .
23467367	0	cortactin	46,55	dynamin_1	36,45	cortactin	dynamin 1	2017	1759	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Stabilization of actin bundles by a dynamin_1 / cortactin ring complex is necessary for growth cone filopodia .
12408982	0	cortactin	21,30	myosin_light_chain_kinase	53,78	cortactin	myosin light chain kinase	2017	4638	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	Novel interaction of cortactin with endothelial cell myosin_light_chain_kinase .
17576929	0	cortactin	84,93	p120_catenin	0,12	cortactin	p120 catenin	2017	1500	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p120_catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin .
10373412	0	cortactin-binding_protein_1	78,105	somatostatin_receptor_subtype_2	41,72	cortactin-binding protein 1	somatostatin receptor subtype 2	171093(Tax:10116)	54305(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Agonist-dependent interaction of the rat somatostatin_receptor_subtype_2 with cortactin-binding_protein_1 .
8391424	0	corticosteroid-binding_globulin	23,54	Interleukin-6	0,13	corticosteroid-binding globulin	Interleukin-6	866	3569	Gene	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Interleukin-6 inhibits corticosteroid-binding_globulin synthesis by human hepatoblastoma-derived -LRB- Hep G2 -RRB- cells .
8615842	0	corticosteroid-binding_globulin	73,104	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	corticosteroid-binding globulin	Pituitary adenylate cyclase-activating polypeptide	299270(Tax:10116)	24166(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide induces expression of corticosteroid-binding_globulin in cultured fetal hepatocytes : synergy with tri-iodothyronine .
7820612	0	corticosterone	11,25	CRH	29,32	corticosterone	CRH	25305(Tax:10116)	81648(Tax:10116)	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Effects of corticosterone on CRH mRNA and content in the bed nucleus of the stria terminalis ; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus .
22484995	0	corticotrophin-releasing_factor	67,98	Neuropeptide_W	0,14	corticotrophin-releasing factor	Neuropeptide W	81648(Tax:10116)	259224(Tax:10116)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Neuropeptide_W stimulates adrenocorticotrophic hormone release via corticotrophin-releasing_factor but not via arginine_vasopressin .
8094652	0	corticotrophin-releasing_factor	11,42	POMC	92,96	corticotrophin-releasing factor	POMC	12917(Tax:10090)	18976(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotrophin-releasing_factor and arginine-vasopressin on proopiomelanocortin -LRB- POMC -RRB- mRNA levels , release and storage of adrenocorticotrophin from mouse anterior pituitary cells .
6332444	0	corticotrophin-releasing_factor	17,48	growth_hormone	71,85	corticotrophin-releasing factor	growth hormone	1392	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of ovine corticotrophin-releasing_factor and hydrocortisone on growth_hormone secretion by pituitary_adenoma cells of acromegaly in culture .
8094652	0	corticotrophin-releasing_factor	11,42	proopiomelanocortin	71,90	corticotrophin-releasing factor	proopiomelanocortin	12917(Tax:10090)	18976(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotrophin-releasing_factor and arginine-vasopressin on proopiomelanocortin -LRB- POMC -RRB- mRNA levels , release and storage of adrenocorticotrophin from mouse anterior pituitary cells .
25189177	0	corticotrophin-releasing_factor	4,35	urocortin	36,45	corticotrophin-releasing factor	urocortin	12917(Tax:10090)	22226(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|system system|compound|END_ENTITY	The corticotrophin-releasing_factor / urocortin system regulates white fat browning in mice through paracrine mechanisms .
9579235	0	corticotrophin-releasing_hormone	18,50	growth_hormone	65,79	corticotrophin-releasing hormone	growth hormone	1392	2688	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|compound|END_ENTITY	Direct effects of corticotrophin-releasing_hormone on stimulated growth_hormone secretion .
22342595	0	corticotrophin_releasing_hormone	52,84	Cortistatin	0,11	corticotrophin releasing hormone	Cortistatin	81648(Tax:10116)	25305(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Cortistatin modulates the expression and release of corticotrophin_releasing_hormone in rat brain .
1849784	0	corticotropin-like_intermediate_lobe_peptide	36,80	CLIP	82,86	corticotropin-like intermediate lobe peptide	CLIP	5443	5443	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Immunohistochemical distribution of corticotropin-like_intermediate_lobe_peptide -LRB- CLIP -RRB- immunoreactivity in the human brain .
1664369	0	corticotropin-releasing-hormone	81,112	CRH	114,117	corticotropin-releasing-hormone	CRH	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Endothelin_3 -LRB- ET3 -RRB- stimulates the hypothalamic-pituitary-adrenal_axis mainly by corticotropin-releasing-hormone -LRB- CRH -RRB- -RSB- .
232792	0	corticotropin-releasing_factor	29,59	ACTH	11,15	corticotropin-releasing factor	ACTH	1392	5443	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Control Control|nmod|END_ENTITY	Control of ACTH secretion by corticotropin-releasing_factor -LRB- s -RRB- .
2830315	1	corticotropin-releasing_factor	93,123	ACTH	197,201	corticotropin-releasing factor	ACTH	1392	5443	Gene	Gene	bioassay|nmod|START_ENTITY provides|nmod|bioassay provides|dobj|evidence evidence|nmod|mediation mediation|nmod|rhythm rhythm|nmod|END_ENTITY	In vivo bioassay of corticotropin-releasing_factor -LRB- CRF -RRB- which provides evidence for CRF mediation of the diurnal rhythm of ACTH .
3039377	0	corticotropin-releasing_factor	52,82	ACTH	34,38	corticotropin-releasing factor	ACTH	1392	5443	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Evidence Evidence|nmod|stimulation stimulation|nmod|END_ENTITY	Evidence for local stimulation of ACTH secretion by corticotropin-releasing_factor in human placenta .
4364642	0	corticotropin-releasing_factor	83,113	ACTH	13,17	corticotropin-releasing factor	ACTH	1392	5443	Gene	Gene	stimulation|nmod|START_ENTITY kinetics|nmod|stimulation Secretion|dep|kinetics Secretion|nmod|END_ENTITY	Secretion of ACTH by isolated anterior pituitary cells : kinetics of stimulation of corticotropin-releasing_factor and of inhibition by corticosterone .
6323156	0	corticotropin-releasing_factor	27,57	ACTH	74,78	corticotropin-releasing factor	ACTH	1392	5443	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of synthetic ovine corticotropin-releasing_factor -LRB- CRF -RRB- on plasma ACTH and cortisol in 31 normal human males .
7489328	0	corticotropin-releasing_factor	46,76	Alpha-melanocyte-stimulating_hormone	0,36	corticotropin-releasing factor	Alpha-melanocyte-stimulating hormone	1392	5443	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Alpha-melanocyte-stimulating_hormone inhibits corticotropin-releasing_factor release by blocking protein kinase C. Cytokine-induced release of corticotropin-releasing_factor -LRB- CRF -RRB- from hypothalamic explants in vitro can be inhibited by femtomolar concentrations of alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- .
8264864	0	corticotropin-releasing_factor	70,100	Alpha-melanocyte-stimulating_hormone	0,36	corticotropin-releasing factor	Alpha-melanocyte-stimulating hormone	1392	5443	Gene	Gene	release|amod|START_ENTITY abolishes|dobj|release abolishes|nsubj|END_ENTITY	Alpha-melanocyte-stimulating_hormone abolishes IL-1 - and IL-6-induced corticotropin-releasing_factor release from the hypothalamus in vitro .
10869378	0	corticotropin-releasing_factor	8,38	CRF	40,43	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Role of corticotropin-releasing_factor -LRB- CRF -RRB- receptors in the anorexic_syndrome induced by CRF .
10949116	0	corticotropin-releasing_factor	8,38	CRF	40,43	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of corticotropin-releasing_factor -LRB- CRF -RRB- in anxiety .
11290855	0	corticotropin-releasing_factor	15,45	CRF	47,50	corticotropin-releasing factor	CRF	12921(Tax:10090)	12918(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Mice that lack corticotropin-releasing_factor -LRB- CRF -RRB- receptors type 1 show a blunted ACTH response to acute alcohol despite up-regulated constitutive hypothalamic CRF gene expression .
12529934	0	corticotropin-releasing_factor	28,58	CRF	60,63	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Pharmacology and biology of corticotropin-releasing_factor -LRB- CRF -RRB- receptors .
12733706	0	corticotropin-releasing_factor	14,44	CRF	46,49	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of corticotropin-releasing_factor -LRB- CRF -RRB- type-1 receptor gene expression by CRF in the hypothalamus .
12733706	0	corticotropin-releasing_factor	14,44	CRF	86,89	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of corticotropin-releasing_factor -LRB- CRF -RRB- type-1 receptor gene expression by CRF in the hypothalamus .
1335535	0	corticotropin-releasing_factor	28,58	CRF	60,63	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of endogenous corticotropin-releasing_factor -LRB- CRF -RRB- in the mediation of the behavioral action of cocaine in rats .
1448118	0	corticotropin-releasing_factor	32,62	CRF	64,67	corticotropin-releasing factor	CRF	100337609(Tax:8355)	100337609(Tax:8355)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the genomic corticotropin-releasing_factor -LRB- CRF -RRB- gene from Xenopus_laevis : two members of the CRF family exist in amphibians .
1494497	0	corticotropin-releasing_factor	14,44	CRF	46,49	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of corticotropin-releasing_factor -LRB- CRF -RRB- on autonomic and behavioral responses during shock-prod burying test in rats .
14971886	0	corticotropin-releasing_factor	13,43	CRF	45,48	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	New class of corticotropin-releasing_factor -LRB- CRF -RRB- antagonists : small peptides having high binding affinity for CRF receptor .
1533382	0	corticotropin-releasing_factor	34,64	CRF	66,69	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Dilatory and inotropic effects of corticotropin-releasing_factor -LRB- CRF -RRB- on the isolated heart .
16423333	0	corticotropin-releasing_factor	24,54	CRF	56,59	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Long-term expression of corticotropin-releasing_factor -LRB- CRF -RRB- in the paraventricular nucleus of the hypothalamus in response to an acute_colonic_inflammation .
1647252	0	corticotropin-releasing_factor	25,55	CRF	57,60	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Age-related decreases in corticotropin-releasing_factor -LRB- CRF -RRB- receptors in rat brain and anterior pituitary gland .
16492754	0	corticotropin-releasing_factor	19,49	CRF	51,54	corticotropin-releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Vital functions of corticotropin-releasing_factor -LRB- CRF -RRB- pathways in maintenance and regulation of energy homeostasis .
169120	0	corticotropin-releasing_factor	47,77	CRF	79,82	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Corticosterone-induced changes in hypothalamic corticotropin-releasing_factor -LRB- CRF -RRB- content after stress .
184025	0	corticotropin-releasing_factor	25,55	CRF	57,60	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Analysis of dynamics of corticotropin-releasing_factor -LRB- CRF -RRB- activity in the rat hypothalamus under stress -RSB- .
21192987	0	corticotropin-releasing_factor	24,54	CRF	56,59	corticotropin-releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of transgenic corticotropin-releasing_factor -LRB- CRF -RRB- over-expression on social recognition memory in mice .
23998289	0	corticotropin-releasing_factor	48,78	CRF	80,83	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A possible solution for hair loss by inhibiting corticotropin-releasing_factor -LRB- CRF -RRB- receptor from traditional Chinese medicine .
2547206	0	corticotropin-releasing_factor	11,41	CRF	43,46	corticotropin-releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Functional corticotropin-releasing_factor -LRB- CRF -RRB- receptors in mouse spleen : evidence from adenylate cyclase studies .
2548115	0	corticotropin-releasing_factor	48,78	CRF	80,83	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Normal pattern of labeling of cerebral cortical corticotropin-releasing_factor -LRB- CRF -RRB- receptors in Alzheimer 's _ disease : evidence from chemical cross-linking studies .
2836182	0	corticotropin-releasing_factor	11,41	CRF	43,46	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotropin-releasing_factor -LRB- CRF -RRB- on aldosterone and 18-hydroxycorticosterone in essential_hypertension and primary_aldosteronism .
2876885	0	corticotropin-releasing_factor	24,54	CRF	56,59	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Cytochemical studies of corticotropin-releasing_factor -LRB- CRF -RRB- receptors in anterior lobe corticotropes : binding , glucocorticoid regulation , and endocytosis of -LSB- biotinyl-Ser1 -RSB- CRF .
2982594	0	corticotropin-releasing_factor	14,44	CRF	46,49	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Regulation of corticotropin-releasing_factor -LRB- CRF -RRB- receptors in the rat pituitary gland : effects of adrenalectomy on CRF receptors and corticotroph responses .
3871498	0	corticotropin-releasing_factor	34,64	CRF	66,69	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Reduction|nmod|START_ENTITY Reduction|appos|END_ENTITY	Reduction in brain immunoreactive corticotropin-releasing_factor -LRB- CRF -RRB- in spontaneously hypertensive rats .
6099779	0	corticotropin-releasing_factor	11,41	CRF	43,46	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotropin-releasing_factor -LRB- CRF -RRB- on aldosterone and 18-hydroxycorticosterone secretion .
6280987	0	corticotropin-releasing_factor	60,90	CRF	92,95	corticotropin-releasing factor	CRF	280755(Tax:9913)	280755(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Differential effects of dithiothreitol and iodoacetamide on corticotropin-releasing_factor -LRB- CRF -RRB- activity of bovine hypothalamic CRFs and vasopressin .
6323156	0	corticotropin-releasing_factor	27,57	CRF	59,62	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of synthetic ovine corticotropin-releasing_factor -LRB- CRF -RRB- on plasma ACTH and cortisol in 31 normal human males .
6760710	0	corticotropin-releasing_factor	35,65	CRF	67,70	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of corticotropin-releasing_factor -LRB- CRF -RRB- in the rat brain .
7720627	0	corticotropin-releasing_factor	40,70	CRF	72,75	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Signaling properties of mouse and human corticotropin-releasing_factor -LRB- CRF -RRB- receptors : decreased coupling efficiency of human type II CRF receptor .
7796142	0	corticotropin-releasing_factor	26,56	CRF	58,61	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Prenatal stress increases corticotropin-releasing_factor -LRB- CRF -RRB- content and release in rat amygdala minces .
8170521	0	corticotropin-releasing_factor	34,64	CRF	66,69	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Depolarization-induced release of corticotropin-releasing_factor -LRB- CRF -RRB- in primary neuronal cultures of the amygdala .
8401569	0	corticotropin-releasing_factor	23,53	CRF	55,58	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of central corticotropin-releasing_factor -LRB- CRF -RRB- in suckling-induced inhibition of luteinizing hormone secretion in lactating rats .
8497182	0	corticotropin-releasing_factor	48,78	CRF	80,83	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Early , postnatal experience alters hypothalamic corticotropin-releasing_factor -LRB- CRF -RRB- mRNA , median eminence CRF content and stress-induced release in adult rats .
8636316	0	corticotropin-releasing_factor	15,45	CRF	47,50	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	High levels of corticotropin-releasing_factor -LRB- CRF -RRB- are inversely correlated with low levels of maternal CRF-binding_protein in pregnant women with pregnancy-induced hypertension .
8697187	0	corticotropin-releasing_factor	15,45	CRF	47,50	corticotropin-releasing factor	CRF	1392	1392	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of the corticotropin-releasing_factor -LRB- CRF -RRB- on rectal afferent nerves in humans .
9396068	0	corticotropin-releasing_factor	14,44	CRF	46,49	corticotropin-releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of corticotropin-releasing_factor -LRB- CRF -RRB- in peritoneum and pericardium in the rat embryo by in situ hybridization histochemistry .
10806401	0	corticotropin-releasing_factor	52,82	CRFR1	145,150	corticotropin-releasing factor	CRFR1	1392	1394	Gene	Gene	studies|amod|START_ENTITY antagonists|nmod|studies antagonists|appos|type_1 type_1|appos|END_ENTITY	Novel high-affinity photoactivatable antagonists of corticotropin-releasing_factor -LRB- CRF -RRB- photoaffinity labeling studies on CRF_receptor , _ type_1 -LRB- CRFR1 -RRB- .
18801728	0	corticotropin-releasing_factor	25,55	CRFR1	90,95	corticotropin-releasing factor	CRFR1	1392	1394	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Molecular recognition of corticotropin-releasing_factor by its G-protein-coupled receptor CRFR1 .
18955489	0	corticotropin-releasing_factor	73,103	CRFR1	116,121	corticotropin-releasing factor	CRFR1	1392	1394	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing_factor receptor 1 -LRB- CRFR1 -RRB- .
3498935	0	corticotropin-releasing_factor	10,40	DBH	52,55	corticotropin-releasing factor	DBH	81648(Tax:10116)	25699(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of corticotropin-releasing_factor on adrenal DBH and PNMT activity .
24246425	0	corticotropin-releasing_factor	15,45	FosB	65,69	corticotropin-releasing factor	FosB	81648(Tax:10116)	100360880	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of corticotropin-releasing_factor gene expression by FosB in rat hypothalamic 4B cells .
21438782	0	corticotropin-releasing_factor	19,49	Ghrelin	0,7	corticotropin-releasing factor	Ghrelin	81648(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Ghrelin stimulates corticotropin-releasing_factor and vasopressin gene expression in rat hypothalamic 4B cells .
26874559	0	corticotropin-releasing_factor	35,65	Ghrelin	0,7	corticotropin-releasing factor	Ghrelin	12918(Tax:10090)	58991(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY activates|dobj|neurons activates|nsubj|END_ENTITY	Ghrelin activates hypophysiotropic corticotropin-releasing_factor neurons independently of the arcuate nucleus .
8264864	0	corticotropin-releasing_factor	70,100	IL-1	47,51	corticotropin-releasing factor	IL-1	1392	3552	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Alpha-melanocyte-stimulating_hormone abolishes IL-1 - and IL-6-induced corticotropin-releasing_factor release from the hypothalamus in vitro .
2821621	0	corticotropin-releasing_factor	55,85	Interleukin-1	0,13	corticotropin-releasing factor	Interleukin-1	1392	3552	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing_factor .
7886628	0	corticotropin-releasing_factor	28,58	Interleukin-1	0,13	corticotropin-releasing factor	Interleukin-1	1392	3552	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|alpha alpha|compound|END_ENTITY	Interleukin-1 alpha induces corticotropin-releasing_factor secretion and synthesis from NPLC-KC cells through various second messenger pathways .
9607726	0	corticotropin-releasing_factor	28,58	Interleukin-1	0,13	corticotropin-releasing factor	Interleukin-1	1392	3552	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Interleukin-1 regulation of corticotropin-releasing_factor -LRB- CRF -RRB- , glucocorticoid_receptor , c-fos and c-jun messenger RNA in the NPLC-KC cell line .
7853199	0	corticotropin-releasing_factor	29,59	Interleukin-2	0,13	corticotropin-releasing factor	Interleukin-2	1392	3558	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- induces corticotropin-releasing_factor -LRB- CRF -RRB- release from the amygdala and involves a nitric_oxide-mediated signaling ; comparison with the hypothalamic response .
1980144	0	corticotropin-releasing_factor	68,98	alpha-1	13,20	corticotropin-releasing factor	alpha-1	1392	146	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Differential alpha-1 and alpha-2 adrenergic effects on hypothalamic corticotropin-releasing_factor and plasma adrenocorticotropin .
11019900	0	corticotropin-releasing_factor	26,56	alpha-melanocyte-stimulating_hormone	114,150	corticotropin-releasing factor	alpha-melanocyte-stimulating hormone	81648(Tax:10116)	24664(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of endogenous corticotropin-releasing_factor in mediation of neuroendocrine and behavioral effects to alpha-melanocyte-stimulating_hormone .
7970145	0	corticotropin-releasing_factor	72,102	alpha-melanocyte-stimulating_hormone	26,62	corticotropin-releasing factor	alpha-melanocyte-stimulating hormone	81648(Tax:10116)	24664(Tax:10116)	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|administration administration|nmod|END_ENTITY	Central administration of alpha-melanocyte-stimulating_hormone inhibits corticotropin-releasing_factor release in adrenalectomized rats .
6320315	0	corticotropin-releasing_factor	58,88	angiotensin_II	10,24	corticotropin-releasing factor	angiotensin II	81648(Tax:10116)	24179(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of angiotensin_II on ACTH release in vivo : role of corticotropin-releasing_factor .
2964553	0	corticotropin-releasing_factor	73,103	atrial_natriuretic_peptide	10,36	corticotropin-releasing factor	atrial natriuretic peptide	81648(Tax:10116)	24602(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Effect of atrial_natriuretic_peptide on acetylcholine-induced release of corticotropin-releasing_factor from rat hypothalamus in vitro .
2528500	0	corticotropin-releasing_factor	49,79	beta-endorphin	12,26	corticotropin-releasing factor	beta-endorphin	1392	5443	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increase of beta-endorphin serum levels by human corticotropin-releasing_factor does not affect beta-cell function in normal-weight men .
19428634	0	corticotropin-releasing_factor	59,89	c-Fos	104,109	corticotropin-releasing factor	c-Fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	attenuates|dep|START_ENTITY peptide|dep|attenuates peptide|dep|expression expression|amod|END_ENTITY	Teneurin_C-terminal associated peptide -LRB- TCAP -RRB- -1 attenuates corticotropin-releasing_factor -LRB- CRF -RRB- - induced c-Fos expression in the limbic system and modulates anxiety_behavior in male Wistar_rats .
14596843	0	corticotropin-releasing_factor	22,52	c-fos	109,114	corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY Effect|nmod|receptors Effect|nmod|nucleus nucleus|nmod|mRNA mRNA|amod|END_ENTITY	Effect of blockade of corticotropin-releasing_factor receptors in the median raphe nucleus on stress-induced c-fos mRNA in the rat brain .
1465198	0	corticotropin-releasing_factor	95,125	c-fos	14,19	corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	forebrain|nmod|START_ENTITY regions|nmod|forebrain END_ENTITY|nmod|regions	Expression of c-fos in regions of the basal limbic forebrain following intracerebroventricular corticotropin-releasing_factor in unstressed or stressed male rats .
1612001	0	corticotropin-releasing_factor	58,88	c-fos	19,24	corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	acid|amod|START_ENTITY expression|nmod|acid precedes|dobj|expression precedes|nsubj|induction induction|nmod|END_ENTITY	Early induction of c-fos precedes increased expression of corticotropin-releasing_factor messenger ribonucleic acid in the paraventricular nucleus after immobilization stress .
1663213	0	corticotropin-releasing_factor	38,68	c-fos	18,23	corticotropin-releasing factor	c-fos	12918(Tax:10090)	14281(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY induced|nmod|gene induced|nsubjpass|END_ENTITY	The protooncogene c-fos is induced by corticotropin-releasing_factor and stimulates proopiomelanocortin gene transcription in pituitary cells .
7783858	0	corticotropin-releasing_factor	42,72	c-fos	95,100	corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY administration|nmod|antagonist attenuates|nsubj|administration attenuates|dobj|expression expression|amod|END_ENTITY	Intracerebroventricular administration of corticotropin-releasing_factor antagonist attenuates c-fos mRNA expression in the paraventricular nucleus after stress .
8019847	0	corticotropin-releasing_factor	106,136	c-fos	31,36	corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Water-avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output : role of corticotropin-releasing_factor .
8358602	0	corticotropin-releasing_factor	42,72	c-fos	176,181	corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY induces|nsubj|administration induces|dobj|expression expression|nmod|regions regions|acl|related related|xcomp|stress stress|dobj|responses responses|dep|comparison comparison|nmod|pattern pattern|nmod|induction induction|amod|END_ENTITY	Intracerebroventricular administration of corticotropin-releasing_factor induces c-fos mRNA expression in brain regions related to stress responses : comparison with pattern of c-fos mRNA induction after stress .
8358602	0	corticotropin-releasing_factor	42,72	c-fos	81,86	corticotropin-releasing factor	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY induces|nsubj|administration induces|dobj|expression expression|amod|END_ENTITY	Intracerebroventricular administration of corticotropin-releasing_factor induces c-fos mRNA expression in brain regions related to stress responses : comparison with pattern of c-fos mRNA induction after stress .
6602951	0	corticotropin-releasing_factor	147,177	corticotropin-releasing_factor	37,67	corticotropin-releasing factor	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of rat hypothalamic corticotropin-releasing_factor by reversed-phase , high-performance liquid chromatography with synthetic ovine corticotropin-releasing_factor as a marker .
6602951	0	corticotropin-releasing_factor	37,67	corticotropin-releasing_factor	147,177	corticotropin-releasing factor	corticotropin-releasing factor	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of rat hypothalamic corticotropin-releasing_factor by reversed-phase , high-performance liquid chromatography with synthetic ovine corticotropin-releasing_factor as a marker .
15582733	0	corticotropin-releasing_factor	63,93	ghrelin	21,28	corticotropin-releasing factor	ghrelin	81648(Tax:10116)	59301(Tax:10116)	Gene	Gene	system|amod|START_ENTITY mediated|nmod|system mediated|nsubjpass|effect effect|nmod|END_ENTITY	Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing_factor system in neonatal chicks .
2865691	0	corticotropin-releasing_factor	99,129	growth_hormone	63,77	corticotropin-releasing factor	growth hormone	81648(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Involvement Involvement|nmod|somatostatin somatostatin|nmod|suppression suppression|nmod|END_ENTITY	Involvement of hypothalamic somatostatin in the suppression of growth_hormone secretion by central corticotropin-releasing_factor in conscious male rats .
2866087	0	corticotropin-releasing_factor	15,45	growth_hormone	95,109	corticotropin-releasing factor	growth hormone	81648(Tax:10116)	81668(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|secretion secretion|amod|END_ENTITY	Involvement of corticotropin-releasing_factor and somatostatin in stress-induced inhibition of growth_hormone secretion in the rat .
6094167	0	corticotropin-releasing_factor	26,56	growth_hormone	60,74	corticotropin-releasing factor	growth hormone	1392	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of synthetic ovine corticotropin-releasing_factor on growth_hormone secretion in patients with acromegaly .
1868353	0	corticotropin-releasing_factor	95,125	interleukin-1	66,79	corticotropin-releasing factor	interleukin-1	12918(Tax:10090)	111343(Tax:10090)	Gene	Gene	involves|dobj|START_ENTITY involves|nsubj|Reduction Reduction|nmod|behavior behavior|nmod|injection injection|nmod|END_ENTITY	Reduction of exploratory behavior by intraperitoneal injection of interleukin-1 involves brain corticotropin-releasing_factor .
17065401	0	corticotropin-releasing_factor	14,44	leptin	80,86	corticotropin-releasing factor	leptin	81648(Tax:10116)	25608(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of corticotropin-releasing_factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress .
9528930	0	corticotropin-releasing_factor	21,51	leptin	11,17	corticotropin-releasing factor	leptin	12918(Tax:10090)	16846(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of leptin on corticotropin-releasing_factor -LRB- CRF -RRB- synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese -LRB- ob/ob -RRB- mice .
2875010	0	corticotropin-releasing_factor	11,41	motilin	52,59	corticotropin-releasing factor	motilin	486977(Tax:9615)	481748(Tax:9615)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_factor on plasma motilin and somatostatin levels and gastrointestinal_motility in dogs .
8592642	0	corticotropin-releasing_factor	19,49	prolactin	78,87	corticotropin-releasing factor	prolactin	81648(Tax:10116)	24683(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|release release|compound|END_ENTITY	Permissive role of corticotropin-releasing_factor in the acute stress-induced prolactin release in female rats .
1628218	0	corticotropin-releasing_factor	12,42	proopiomelanocortin	83,102	corticotropin-releasing factor	proopiomelanocortin	81648(Tax:10116)	24664(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|compound|END_ENTITY	The role of corticotropin-releasing_factor and vasopressin in hypoglycemia-induced proopiomelanocortin gene expression in the rat anterior pituitary gland .
6319453	0	corticotropin-releasing_factor	20,50	vasopressin	69,80	corticotropin-releasing factor	vasopressin	1392	551	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of ovine corticotropin-releasing_factor on catecholamine , vasopressin , and aldosterone secretion in normal man .
1517398	0	corticotropin-releasing_factor-41	27,60	Interleukin-1_beta	0,18	corticotropin-releasing factor-41	Interleukin-1 beta	81648(Tax:10116)	24494(Tax:10116)	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Interleukin-1_beta induces corticotropin-releasing_factor-41 release from cultured hypothalamic cells through protein kinase C and cAMP-dependent protein kinase pathways .
7472399	0	corticotropin-releasing_factor_receptor	22,61	CRF2	63,67	corticotropin-releasing factor receptor	CRF2	64680(Tax:10116)	64680(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Localization of novel corticotropin-releasing_factor_receptor -LRB- CRF2 -RRB- mRNA expression to specific subcortical nuclei in rat brain : comparison with CRF1 receptor mRNA expression .
9822161	0	corticotropin-releasing_factor_receptor_type_1	27,73	CRFR1	75,80	corticotropin-releasing factor receptor type 1	CRFR1	58959(Tax:10116)	58959(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of native corticotropin-releasing_factor_receptor_type_1 -LRB- CRFR1 -RRB- in the rat and mouse central nervous system .
10234028	0	corticotropin-releasing_factor_receptor_type_2	45,91	CRF2	93,97	corticotropin-releasing factor receptor type 2	CRF2	64680(Tax:10116)	64680(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulation|nmod|expression regulation|appos|END_ENTITY	Differential regulation of the expression of corticotropin-releasing_factor_receptor_type_2 -LRB- CRF2 -RRB- in hypothalamus and amygdala of the immature rat by sensory input and food intake .
26456805	0	corticotropin-releasing_factor_type-1	207,244	CRF1	246,250	corticotropin-releasing factor type-1	CRF1	1394	1394	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Synthesis , binding affinity , radiolabeling , and microPET evaluation of 4 - -LRB- 2-substituted-4-substituted -RRB- -8 - -LRB- dialkylamino -RRB- -6 - methyl-1-substituted-3 ,4 - dihydropyrido -LSB- 2,3-b -RSB- pyrazin-2 -LRB- 1H -RRB- - ones as ligands for brain corticotropin-releasing_factor_type-1 -LRB- CRF1 -RRB- receptors .
15349973	0	corticotropin-releasing_factor_type_1	37,74	CRF1	76,80	corticotropin-releasing factor type 1	CRF1	574095(Tax:9544)	574095(Tax:9544)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Immunohistochemical visualization of corticotropin-releasing_factor_type_1 -LRB- CRF1 -RRB- receptors in monkey brain .
2840977	0	corticotropin-releasing_hormone	39,70	ACTH	12,16	corticotropin-releasing hormone	ACTH	1392	5443	Gene	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of ACTH and cortisol to human corticotropin-releasing_hormone after short-term abstention from alcohol_abuse .
12062896	0	corticotropin-releasing_hormone	26,57	AP-2alpha	0,9	corticotropin-releasing hormone	AP-2alpha	1392	7020	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	AP-2alpha modulates human corticotropin-releasing_hormone gene expression in the placenta by direct protein-protein interaction .
8988798	0	corticotropin-releasing_hormone	54,85	Adrenocorticotropic_hormone	0,27	corticotropin-releasing hormone	Adrenocorticotropic hormone	1392	5443	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Adrenocorticotropic_hormone and cortisol responses to corticotropin-releasing_hormone : changes in panic_disorder and effects of alprazolam treatment .
8045978	0	corticotropin-releasing_hormone	74,105	Alpha-melanocyte-stimulating_hormone	0,36	corticotropin-releasing hormone	Alpha-melanocyte-stimulating hormone	1392	5443	Gene	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	Alpha-melanocyte-stimulating_hormone antagonizes the inhibitory effect of corticotropin-releasing_hormone on luteinizing hormone secretion during the luteal phase in normal women .
23768074	0	corticotropin-releasing_hormone	49,80	CREB	33,37	corticotropin-releasing hormone	CREB	1392	1385	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Differential contribution of CBP : CREB binding to corticotropin-releasing_hormone expression in the infant and adult hypothalamus .
10230640	0	corticotropin-releasing_hormone	31,62	CRH	64,67	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	4-Aryl-2-anilinopyrimidines as corticotropin-releasing_hormone -LRB- CRH -RRB- antagonists .
11287050	0	corticotropin-releasing_hormone	10,41	CRH	43,46	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Decreased corticotropin-releasing_hormone -LRB- CRH -RRB- concentrations in the cerebrospinal fluid of eucortisolemic suicide attempters .
12213307	0	corticotropin-releasing_hormone	24,55	CRH	57,60	corticotropin-releasing hormone	CRH	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Differential release of corticotropin-releasing_hormone -LRB- CRH -RRB- in the amygdala during different types of stressors .
15606911	0	corticotropin-releasing_hormone	14,45	CRH	47,50	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Covariates of corticotropin-releasing_hormone -LRB- CRH -RRB- concentrations in cerebrospinal fluid -LRB- CSF -RRB- from healthy humans .
15882914	0	corticotropin-releasing_hormone	166,197	CRH	199,202	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- mimics neuroendocrine and behavioral manifestations of stress : Evidence for PKA-mediated expression of the corticotropin-releasing_hormone -LRB- CRH -RRB- gene .
15944267	0	corticotropin-releasing_hormone	25,56	CRH	58,61	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Human mast cells express corticotropin-releasing_hormone -LRB- CRH -RRB- receptors and CRH leads to selective secretion of vascular_endothelial_growth_factor .
16416158	0	corticotropin-releasing_hormone	126,157	CRH	159,162	corticotropin-releasing hormone	CRH	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Developmental exposure to corticosterone : behavioral changes and differential effects on leukemia_inhibitory_factor -LRB- LIF -RRB- and corticotropin-releasing_hormone -LRB- CRH -RRB- gene expression in the mouse .
17127497	0	corticotropin-releasing_hormone	21,52	CRH	54,57	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Terbutaline inhibits corticotropin-releasing_hormone -LRB- CRH -RRB- expression in human trophoblast cells .
17507918	0	corticotropin-releasing_hormone	36,67	CRH	69,72	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Ovarian steroid treatment decreases corticotropin-releasing_hormone -LRB- CRH -RRB- mRNA and protein in the hypothalamic paraventricular nucleus of ovariectomized monkeys .
20006448	0	corticotropin-releasing_hormone	25,56	CRH	58,61	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of maternal serum corticotropin-releasing_hormone -LRB- CRH -RRB- at midpregnancy in relation to maternal characteristics .
2093479	0	corticotropin-releasing_hormone	11,42	CRH	44,47	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of corticotropin-releasing_hormone -LRB- CRH -RRB- in maternal and fetal plasma and in amniotic fluid .
2176309	0	corticotropin-releasing_hormone	51,82	CRH	84,87	corticotropin-releasing hormone	CRH	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Effects of cortisol treatment on brain and adrenal corticotropin-releasing_hormone -LRB- CRH -RRB- content and other parameters regulated by CRH .
21765902	0	corticotropin-releasing_hormone	27,58	CRH	60,63	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role of peripheral corticotropin-releasing_hormone -LRB- CRH -RRB- on dermal fibroblasts .
2401449	0	corticotropin-releasing_hormone	18,49	CRH	51,54	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the corticotropin-releasing_hormone -LRB- CRH -RRB- gene in human placenta and amniotic membrane .
7951540	0	corticotropin-releasing_hormone	11,42	CRH	44,47	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Low plasma corticotropin-releasing_hormone -LRB- CRH -RRB- levels in patients with non-insulin_dependent_diabetes_mellitus -LRB- NIDDM -RRB- .
9476637	0	corticotropin-releasing_hormone	14,45	CRH	47,50	corticotropin-releasing hormone	CRH	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of corticotropin-releasing_hormone -LRB- CRH -RRB- on the adrenal medulla in hypophysectomized rats .
9506767	0	corticotropin-releasing_hormone	20,51	CRH	53,56	corticotropin-releasing hormone	CRH	1392	1392	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of corticotropin-releasing_hormone -LRB- CRH -RRB- in human skin .
16424794	0	corticotropin-releasing_hormone	11,42	CRH-receptor_subtype_R1_and_R2	83,113	corticotropin-releasing hormone	CRH-receptor subtype R1 and R2	1392	913	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Effects of corticotropin-releasing_hormone -LRB- CRH -RRB- on monocyte function , mediated by CRH-receptor_subtype_R1_and_R2 : a potential link between mood_disorders and endothelial_dysfunction ?
20693543	0	corticotropin-releasing_hormone	82,113	Dendritic_cell_nuclear_protein-1	0,32	corticotropin-releasing hormone	Dendritic cell nuclear protein-1	1392	140947	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Dendritic_cell_nuclear_protein-1 , a novel depression-related protein , upregulates corticotropin-releasing_hormone expression .
18771998	0	corticotropin-releasing_hormone	55,86	MyD88	106,111	corticotropin-releasing hormone	MyD88	1392	4615	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Lipopolysaccharide stimulation of trophoblasts induces corticotropin-releasing_hormone expression through MyD88 .
10936035	0	corticotropin-releasing_hormone	278,309	alpha-melanocyte-stimulating_hormone	230,266	corticotropin-releasing hormone	alpha-melanocyte-stimulating hormone	1392	5443	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Pituitary proopiomelanocortin-derived peptides and hypothalamus-pituitary-interrenal_axis activity in gilthead sea bream -LRB- Sparus aurata -RRB- during prolonged crowding stress : differential regulation of adrenocorticotropin hormone and alpha-melanocyte-stimulating_hormone release by corticotropin-releasing_hormone and thyrotropin-releasing_hormone .
9624601	0	corticotropin-releasing_hormone	129,160	atrial_natriuretic_factor	7,32	corticotropin-releasing hormone	atrial natriuretic factor	1392	4878	Gene	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Plasma atrial_natriuretic_factor levels in the inferior_petrosal_sinus blood of patients with Cushing 's _ disease before and after corticotropin-releasing_hormone administration .
7675938	0	corticotropin-releasing_hormone	57,88	beta-endorphin	29,43	corticotropin-releasing hormone	beta-endorphin	1392	5443	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Cortisol , corticotropin , and beta-endorphin responses to corticotropin-releasing_hormone in patients with atopic_eczema .
18307898	0	corticotropin-releasing_hormone	61,92	c-Fos	94,99	corticotropin-releasing hormone	c-Fos	1392	2353	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	-LSB- Clinical study of the correlation among the levels of human corticotropin-releasing_hormone , c-Fos and connexin-43 at onset of labor -RSB- .
15147776	0	corticotropin-releasing_hormone	79,110	c-fos	55,60	corticotropin-releasing hormone	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Effect of naloxone-precipitated morphine withdrawal on c-fos expression in rat corticotropin-releasing_hormone neurons in the paraventricular_hypothalamus and extended amygdala .
1784425	0	corticotropin-releasing_hormone	86,117	c-fos	14,19	corticotropin-releasing hormone	c-fos	81648(Tax:10116)	314322(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of c-fos mRNA in rat brain after intracerebroventricular administration of corticotropin-releasing_hormone .
19460861	0	corticotropin-releasing_hormone	96,127	connexin_43	10,21	corticotropin-releasing hormone	connexin 43	1392	2697	Gene	Gene	activity|nmod|START_ENTITY mediator|nmod|activity expression|nmod|mediator expression|amod|END_ENTITY	Increased connexin_43 expression as a potential mediator of the neuroprotective activity of the corticotropin-releasing_hormone .
27080003	0	corticotropin-releasing_hormone	59,90	corticotropin-releasing_hormone	91,122	corticotropin-releasing hormone	corticotropin-releasing hormone	100127468(Tax:9823)	100127468(Tax:9823)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing_hormone / corticotropin-releasing_hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge .
27080003	0	corticotropin-releasing_hormone	91,122	corticotropin-releasing_hormone	59,90	corticotropin-releasing hormone	corticotropin-releasing hormone	100127468(Tax:9823)	100127468(Tax:9823)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing_hormone / corticotropin-releasing_hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge .
21791179	0	corticotropin-releasing_hormone	11,42	gonadotrophin-releasing_hormone	88,119	corticotropin-releasing hormone	gonadotrophin-releasing hormone	1392	2796	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of corticotropin-releasing_hormone and its antagonist on the gene expression of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- and GnRH_receptor in the hypothalamus and anterior pituitary gland of follicular phase ewes .
11085902	0	corticotropin-releasing_hormone	50,81	gp120	41,46	corticotropin-releasing hormone	gp120	81648(Tax:10116)	155971(Tax:11676)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing_hormone and arginine_vasopressin in the rat hypothalamus : involvement of nitric_oxide .
12372984	0	corticotropin-releasing_hormone	99,130	interleukin-1	51,64	corticotropin-releasing hormone	interleukin-1	1392	3552	Gene	Gene	involvement|nmod|START_ENTITY involvement|amod|END_ENTITY	Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotropin-releasing_hormone .
11525798	0	corticotropin-releasing_hormone	46,77	interleukin-2	11,24	corticotropin-releasing hormone	interleukin-2	81648(Tax:10116)	116562(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of interleukin-2 on the expression of corticotropin-releasing_hormone in nerves and lymphoid cells in secondary lymphoid organs from the Fischer 344 rat .
9604864	0	corticotropin-releasing_hormone	13,44	leptin	89,95	corticotropin-releasing hormone	leptin	81648(Tax:10116)	25608(Tax:10116)	Gene	Gene	mediator|nsubj|START_ENTITY mediator|nmod|effect effect|nmod|END_ENTITY	Hypothalamic corticotropin-releasing_hormone is a mediator of the anorexigenic effect of leptin .
20966530	0	corticotropin-releasing_hormone	49,80	nesfatin-1	28,38	corticotropin-releasing hormone	nesfatin-1	81648(Tax:10116)	59295(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY activates|dobj|neurons activates|nsubj|END_ENTITY	Stressor-responsive central nesfatin-1 activates corticotropin-releasing_hormone , noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal_axis .
10536983	0	corticotropin-releasing_hormone	35,66	proopiomelanocortin	14,33	corticotropin-releasing hormone	proopiomelanocortin	1392	5443	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of proopiomelanocortin , corticotropin-releasing_hormone -LRB- CRH -RRB- , and CRH receptor in melanoma cells , nevus cells , and normal human melanocytes .
16840545	0	corticotropin-releasing_hormone	235,266	proopiomelanocortin	65,84	corticotropin-releasing hormone	proopiomelanocortin	404297(Tax:9031)	24664(Tax:10116)	Gene	Gene	pressure|nmod|START_ENTITY vitro|nmod|pressure decline|acl|vitro type|dep|decline type|acl|coexpressing coexpressing|dobj|acid acid|nmod|END_ENTITY	A Pituitary cell type coexpressing messenger ribonucleic acid of proopiomelanocortin and the glycoprotein_hormone_alpha-subunit in neonatal rat and chicken : rapid decline with age and reappearance in vitro under regulatory pressure of corticotropin-releasing_hormone in the rat .
18827746	0	corticotropin-releasing_hormone	113,144	proopiomelanocortin	46,65	corticotropin-releasing hormone	proopiomelanocortin	1392	5443	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|derivatives derivatives|compound|END_ENTITY	Release of melanotroph - and corticotroph-type proopiomelanocortin derivatives into blood after administration of corticotropin-releasing_hormone in patients with septic_shock without adrenocortical_insufficiency .
23891702	0	corticotropin-releasing_hormone	11,42	proopiomelanocortin	46,65	corticotropin-releasing hormone	proopiomelanocortin	1392	5443	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|derivatives derivatives|compound|END_ENTITY	Effects of corticotropin-releasing_hormone on proopiomelanocortin derivatives and monocytic HLA-DR expression in patients with septic_shock .
2839542	0	corticotropin-releasing_hormone	11,42	proopiomelanocortin	64,83	corticotropin-releasing hormone	proopiomelanocortin	1392	5443	Gene	Gene	START_ENTITY|nmod|messenger messenger|compound|END_ENTITY	Effects of corticotropin-releasing_hormone and dexamethasone on proopiomelanocortin messenger RNA level in human corticotroph_adenoma cells in vitro .
2856398	0	corticotropin-releasing_hormone	82,113	proopiomelanocortin	40,59	corticotropin-releasing hormone	proopiomelanocortin	1392	5443	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|gene gene|compound|END_ENTITY	Tissue-specific regulation of pituitary proopiomelanocortin gene transcription by corticotropin-releasing_hormone , 3 ' ,5 ' - cyclic_adenosine_monophosphate , and glucocorticoids .
19596122	0	corticotropin-releasing_hormone	51,82	retinoic_acid_receptor-alpha	19,47	corticotropin-releasing hormone	retinoic acid receptor-alpha	1392	5914	Gene	Gene	expression|amod|START_ENTITY involvement|nmod|expression involvement|nmod|END_ENTITY	The involvement of retinoic_acid_receptor-alpha in corticotropin-releasing_hormone gene expression and affective_disorders .
16337947	0	corticotropin-releasing_hormone	8,39	thyrotropin-releasing_factor	45,73	corticotropin-releasing hormone	thyrotropin-releasing factor	1392	7200	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of corticotropin-releasing_hormone as a thyrotropin-releasing_factor in non-mammalian vertebrates .
1671867	0	corticotropin-releasing_hormone	47,78	tyrosine_hydroxylase	80,100	corticotropin-releasing hormone	tyrosine hydroxylase	81648(Tax:10116)	25085(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Long-term antidepressant administration alters corticotropin-releasing_hormone , tyrosine_hydroxylase , and mineralocorticoid receptor gene expression in rat brain .
12746287	0	corticotropin-releasing_hormone	28,59	urocortin	61,70	corticotropin-releasing hormone	urocortin	1392	7349	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	High levels of intrauterine corticotropin-releasing_hormone , urocortin , tryptase , and interleukin-8 in spontaneous_abortions .
18484196	0	corticotropin-releasing_hormone	11,42	vascular_endothelial_growth_factor	62,96	corticotropin-releasing hormone	vascular endothelial growth factor	1392	7422	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of corticotropin-releasing_hormone and stresscopin on vascular_endothelial_growth_factor mRNA expression in cultured early human extravillous trophoblasts .
22006535	0	corticotropin-releasing_hormone-binding_protein	47,94	CRH-BP	96,102	corticotropin-releasing hormone-binding protein	CRH-BP	409372(Tax:7460)	409372(Tax:7460)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of a novel corticotropin-releasing_hormone-binding_protein -LRB- CRH-BP -RRB- gene from Chinese honeybee -LRB- Apis_cerana cerana -RRB- .
11796746	0	corticotropin-releasing_hormone_binding_protein	29,76	CRH-BP	78,84	corticotropin-releasing hormone binding protein	CRH-BP	29625(Tax:10116)	29625(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of corticotropin-releasing_hormone_binding_protein -LRB- CRH-BP -RRB- in rat adrenals .
17947358	0	corticotropin-releasing_hormone_gene	20,56	crh	58,61	corticotropin-releasing hormone gene	crh	1392	1392	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Estradiol regulates corticotropin-releasing_hormone_gene -LRB- crh -RRB- expression in a rapid and phasic manner that parallels estrogen_receptor-alpha_and _ - beta recruitment to a 3 ' ,5 ' - cyclic_adenosine_5 ' - monophosphate regulatory region of the proximal crh promoter .
10367986	0	corticotropin-releasing_hormone_receptor	18,58	CRH-R	60,65	corticotropin-releasing hormone receptor	CRH-R	12921(Tax:10090)	12921(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	The rationale for corticotropin-releasing_hormone_receptor -LRB- CRH-R -RRB- antagonists to treat depression and anxiety .
11857585	0	corticotropin-releasing_hormone_receptor-2	48,90	CRHR2	92,97	corticotropin-releasing hormone receptor-2	CRHR2	1395	1395	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Gene-based SNP genetic association study of the corticotropin-releasing_hormone_receptor-2 -LRB- CRHR2 -RRB- in major depression .
16884458	0	corticotropin-releasing_hormone_receptor_2	20,62	CRHR2	64,69	corticotropin-releasing hormone receptor 2	CRHR2	1395	1395	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between corticotropin-releasing_hormone_receptor_2 -LRB- CRHR2 -RRB- gene polymorphism and personality traits .
18706413	0	corticotropin-releasing_hormone_receptor_2	23,65	CRHR2	67,72	corticotropin-releasing hormone receptor 2	CRHR2	64680(Tax:10116)	64680(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen regulation of corticotropin-releasing_hormone_receptor_2 -LRB- CRHR2 -RRB- mRNA expression and receptor binding in the rat brain .
8412510	0	corticotropin_releasing_factor	71,101	Alpha-melanocyte_stimulating_hormone	0,36	corticotropin releasing factor	Alpha-melanocyte stimulating hormone	81648(Tax:10116)	24664(Tax:10116)	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	Alpha-melanocyte_stimulating_hormone -LRB- MSH -RRB- antagonizes the anorexia by corticotropin_releasing_factor -LRB- CRF -RRB- .
12397512	0	corticotropin_releasing_factor	11,41	CRF	43,46	corticotropin releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for corticotropin_releasing_factor -LRB- CRF -RRB- in ethanol consumption , sensitivity , and reward as revealed by CRF-deficient mice .
12845406	0	corticotropin_releasing_factor	8,38	CRF	40,43	corticotropin releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of corticotropin_releasing_factor -LRB- CRF -RRB- receptors 1 and 2 in CRF-potentiated acoustic startle in mice .
18397172	0	corticotropin_releasing_factor	34,64	CRF	66,69	corticotropin releasing factor	CRF	1392	1392	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Small molecule antagonists of the corticotropin_releasing_factor -LRB- CRF -RRB- receptor : recent medicinal chemistry developments .
18595780	0	corticotropin_releasing_factor	24,54	CRF	56,59	corticotropin releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Postnatal expression of corticotropin_releasing_factor -LRB- CRF -RRB- in rat urinary bladder .
21651923	0	corticotropin_releasing_factor	11,41	CRF	43,46	corticotropin releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotropin_releasing_factor -LRB- CRF -RRB- on sleep and body temperature following controllable footshock stress in mice .
26283899	0	corticotropin_releasing_factor	11,41	CRF	43,46	corticotropin releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotropin_releasing_factor -LRB- CRF -RRB- on sleep and temperature following predictable controllable and uncontrollable stress in mice .
26283899	0	corticotropin_releasing_factor	11,41	CRF	43,46	corticotropin releasing factor	CRF	12918(Tax:10090)	12918(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotropin_releasing_factor -LRB- CRF -RRB- on sleep and temperature following predictable controllable and uncontrollable stress in mice .
3498936	0	corticotropin_releasing_factor	17,47	CRF	49,52	corticotropin releasing factor	CRF	1392	1392	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of human corticotropin_releasing_factor -LRB- CRF -RRB- on gastric and pancreatic secretion in vivo and in vitro .
6194860	0	corticotropin_releasing_factor	35,65	CRF	67,70	corticotropin releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of corticotropin_releasing_factor -LRB- CRF -RRB- in the rat spinal cord .
9016842	0	corticotropin_releasing_factor	10,40	CRF	42,45	corticotropin releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of corticotropin_releasing_factor -LRB- CRF -RRB- injected into the median eminence on LH secretion in male rats .
9299209	0	corticotropin_releasing_factor	42,72	CRF	74,77	corticotropin releasing factor	CRF	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Stress-induced sleep_deprivation modifies corticotropin_releasing_factor -LRB- CRF -RRB- levels and CRF binding in rat brain and pituitary .
14724392	0	corticotropin_releasing_factor	27,57	CRF-R1	68,74	corticotropin releasing factor	CRF-R1	12918(Tax:10090)	12921(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Localization of the type 1 corticotropin_releasing_factor receptor -LRB- CRF-R1 -RRB- in the embryonic mouse cerebellum .
25960164	0	corticotropin_releasing_factor	25,55	CRF-R1	66,72	corticotropin releasing factor	CRF-R1	1392	1394	Gene	Gene	receptor|compound|START_ENTITY activation|nmod|receptor activation|appos|END_ENTITY	The activation of type 1 corticotropin_releasing_factor receptor -LRB- CRF-R1 -RRB- inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27 -LRB- Kip1 -RRB- protein up-regulation and c-Myc mRNA down-regulation .
25665407	0	corticotropin_releasing_factor	11,41	CRF1	109,113	corticotropin releasing factor	CRF1	81648(Tax:10116)	58959(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|involvement involvement|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of corticotropin_releasing_factor -LRB- CRF -RRB- on somatic_pain sensitivity in conscious rats : involvement of CRF1 and CRF2 receptors -RSB- .
9372207	0	corticotropin_releasing_factor	53,83	CRF1	4,8	corticotropin releasing factor	CRF1	81648(Tax:10116)	58959(Tax:10116)	Gene	Gene	actions|nmod|START_ENTITY mediates|dobj|actions mediates|nsubj|receptor receptor|compound|END_ENTITY	The CRF1 receptor mediates the excitatory actions of corticotropin_releasing_factor -LRB- CRF -RRB- in the developing rat brain : in vivo evidence using a novel , selective , non-peptide CRF receptor antagonist .
9863624	0	corticotropin_releasing_factor	43,73	CRF1	84,88	corticotropin releasing factor	CRF1	1392	1394	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Structure and function of the ovine type 1 corticotropin_releasing_factor receptor -LRB- CRF1 -RRB- and a carboxyl-terminal variant .
8876664	0	corticotropin_releasing_factor	55,85	atrial_natriuretic_peptide	15,41	corticotropin releasing factor	atrial natriuretic peptide	81648(Tax:10116)	24602(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of atrial_natriuretic_peptide -LRB- ANP1-28 -RRB- on corticotropin_releasing_factor in brain of rats .
10447453	0	corticotropin_releasing_factor	10,40	growth_hormone	78,92	corticotropin releasing factor	growth hormone	81648(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY injected|nsubj|Effect injected|nmod|eminence eminence|nmod|secretion secretion|amod|END_ENTITY	Effect of corticotropin_releasing_factor injected into the median eminence on growth_hormone secretion in male rats .
15127940	0	corticotropin_releasing_factor_1	29,61	CRF1	63,67	corticotropin releasing factor 1	CRF1	58959(Tax:10116)	58959(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Conformational states of the corticotropin_releasing_factor_1 -LRB- CRF1 -RRB- receptor : detection , and pharmacological evaluation by peptide ligands .
18670748	0	corticotropin_releasing_factor_receptor_2	15,56	CRFR2	58,63	corticotropin releasing factor receptor 2	CRFR2	1395	1395	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of corticotropin_releasing_factor_receptor_2 -LRB- CRFR2 -RRB- in the human prostate .
22948128	0	corticotropin_releasing_factor_receptor_type_1	14,60	CRF1	62,66	corticotropin releasing factor receptor type 1	CRF1	1394	1394	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of corticotropin_releasing_factor_receptor_type_1 -LRB- CRF1 -RRB- in the human gastrointestinal tract and upregulation in the colonic_mucosa in patients with ulcerative_colitis .
11939721	0	corticotropin_releasing_hormone	17,48	CRH	50,53	corticotropin releasing hormone	CRH	81648(Tax:10116)	81648(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of the corticotropin_releasing_hormone -LRB- CRH -RRB- on the brain-blood barrier permeability in cerebral_ischemia in rats .
16309788	0	corticotropin_releasing_hormone	91,122	CRH	124,127	corticotropin releasing hormone	CRH	1392	1392	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin_releasing_hormone -LRB- CRH -RRB- : priming the placental clock .
9026271	0	corticotropin_releasing_hormone	24,55	CRH	57,60	corticotropin releasing hormone	CRH	1392	1392	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Differential changes of corticotropin_releasing_hormone -LRB- CRH -RRB- concentrations in plasma and synovial fluids of patients with rheumatoid_arthritis -LRB- RA -RRB- .
8600981	0	corticotropin_releasing_hormone_receptor	52,92	CRH-R	94,99	corticotropin releasing hormone receptor	CRH-R	12921(Tax:10090)	12921(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The expression of proopiomelanocortin -LRB- POMC -RRB- and of corticotropin_releasing_hormone_receptor -LRB- CRH-R -RRB- genes in mouse skin .
15992556	0	corticotropin_releasing_hormone_receptor_1	67,109	CRHR1	111,116	corticotropin releasing hormone receptor 1	CRHR1	1394	1394	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between single nucleotide polymorphisms in the corticotropin_releasing_hormone_receptor_1 -LRB- CRHR1 -RRB- gene and alcohol_dependence .
16550213	0	corticotropin_releasing_hormone_receptor_1	33,75	CRHR1	77,82	corticotropin releasing hormone receptor 1	CRHR1	1394	1394	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Genetic association of the human corticotropin_releasing_hormone_receptor_1 -LRB- CRHR1 -RRB- with binge drinking and alcohol intake patterns in two independent samples .
11842537	0	costimulatory_adhesion_molecule	17,48	CD80	50,54	costimulatory adhesion molecule	CD80	25408(Tax:10116)	25408(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	-LSB- Upregulation of costimulatory_adhesion_molecule -LRB- CD80 -RRB- in rat kidney with ischemia/reperfusion injury -RSB- .
7594462	1	costimulatory_molecule	139,161	adenosine_deaminase	116,135	costimulatory molecule	adenosine deaminase	80381	100	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of adenosine_deaminase as costimulatory_molecule .
10490589	0	coumarin_7-hydroxylase	70,92	Cyp2a5	94,100	coumarin 7-hydroxylase	Cyp2a5	13087(Tax:10090)	13087(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Circadian expression of the steroid 15 alpha-hydroxylase -LRB- Cyp2a4 -RRB- and coumarin_7-hydroxylase -LRB- Cyp2a5 -RRB- genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP .
8352886	0	coumarin_7-hydroxylase	41,63	cytochrome_P450_2a-5	19,39	coumarin 7-hydroxylase	cytochrome P450 2a-5	13087(Tax:10090)	13087(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	High expression of cytochrome_P450_2a-5 -LRB- coumarin_7-hydroxylase -RRB- in mouse hepatomas .
19835666	0	cox-1	59,64	iNOS	65,69	cox-1	iNOS	5742	4843	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Autoantibodies from schizophrenia patients induce cerebral cox-1 / iNOS mRNA expression with NO/PGE2/MMP -3 production .
11477578	0	cox-2	28,33	cyclooxygenase-2	10,26	cox-2	cyclooxygenase-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Increased cyclooxygenase-2 -LRB- cox-2 -RRB- expression and activity in a murine model of metastatic breast_cancer .
15761871	0	coxsackie_adenovirus_receptor	6,35	CAR	37,40	coxsackie adenovirus receptor	CAR	13052(Tax:10090)	13052(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Human coxsackie_adenovirus_receptor -LRB- CAR -RRB- expression in transgenic mouse prostate_tumors enhances adenoviral delivery of genes .
16014330	0	coxsackie_virus_and_adenovirus_receptor	16,55	CAR	57,60	coxsackie virus and adenovirus receptor	CAR	1525	1525	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of coxsackie_virus_and_adenovirus_receptor -LRB- CAR -RRB- in normal and regenerating human muscle .
26483283	0	coxsackievirus_and_adenovirus_receptor	8,46	CAR	48,51	coxsackievirus and adenovirus receptor	CAR	1525	1525	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Role of coxsackievirus_and_adenovirus_receptor -LRB- CAR -RRB- expression and viral load of adenovirus and enterovirus in patients with dilated_cardiomyopathy .
15364909	0	coxsackievirus_and_adenovirus_receptor	4,42	MUPP-1	90,96	coxsackievirus and adenovirus receptor	MUPP-1	1525	8777	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The coxsackievirus_and_adenovirus_receptor interacts with the multi-PDZ_domain_protein-1 -LRB- MUPP-1 -RRB- within the tight junction .
16081942	0	cpb2	46,50	beta2-toxin	28,39	cpb2	beta2-toxin	13918017	13918017	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Regulated expression of the beta2-toxin gene -LRB- cpb2 -RRB- in Clostridium_perfringens type a isolates from horses with gastrointestinal_diseases .
8661155	0	creatine_transporter	36,56	CRTR	58,62	creatine transporter	CRTR	6535	6535	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The genomic organization of a human creatine_transporter -LRB- CRTR -RRB- gene located in Xq28 .
23013026	0	creb	36,40	Bcl-2	9,14	creb	Bcl-2	81646(Tax:10116)	24224(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity END_ENTITY|nmod|regulation	-LSB- Role of Bcl-2 in the regulation of creb activity and vasopressin expression in the hypothalamic neurons of rats -RSB- .
17947358	0	crh	58,61	corticotropin-releasing_hormone_gene	20,56	crh	corticotropin-releasing hormone gene	1392	1392	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Estradiol regulates corticotropin-releasing_hormone_gene -LRB- crh -RRB- expression in a rapid and phasic manner that parallels estrogen_receptor-alpha_and _ - beta recruitment to a 3 ' ,5 ' - cyclic_adenosine_5 ' - monophosphate regulatory region of the proximal crh promoter .
11389483	0	crumbs_homologue_1	128,146	CRB1	148,152	crumbs homologue 1	CRB1	23418	23418	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Leber_congenital_amaurosis and retinitis_pigmentosa with Coats-like exudative vasculopathy are associated with mutations in the crumbs_homologue_1 -LRB- CRB1 -RRB- gene .
19878675	0	cryab	38,43	alphaB-crystallin	19,36	cryab	alphaB-crystallin	396089(Tax:9031)	396089(Tax:9031)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes in retinal alphaB-crystallin -LRB- cryab -RRB- RNA transcript levels during periods of altered ocular growth in chickens .
10924469	0	cryptocephal	4,16	ATF4	23,27	cryptocephal	ATF4	47767(Tax:7227)	47767(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The cryptocephal gene -LRB- ATF4 -RRB- encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila .
21511871	0	cryptochrome_1	12,26	SPA1	42,46	cryptochrome 1	SPA1	826470(Tax:3702)	819242(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Arabidopsis cryptochrome_1 interacts with SPA1 to suppress COP1 activity in response to blue light .
9881166	0	cryptochrome_1	24,38	phytochrome_A_and_B	64,83	cryptochrome 1	phytochrome A and B	826470(Tax:3702)	837483;816394	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	The blue light receptor cryptochrome_1 can act independently of phytochrome_A_and_B in Arabidopsis_thaliana .
19718746	0	crystallin	42,52	D-Pax2	25,31	crystallin	D-Pax2	34604(Tax:7227)	43825(Tax:7227)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The transcription factor D-Pax2 regulates crystallin production during eye development in Drosophila_melanogaster .
22792142	0	crystallin_beta_A4	32,50	CRYBA4	52,58	crystallin beta A4	CRYBA4	1413	1413	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of high_myopia with crystallin_beta_A4 -LRB- CRYBA4 -RRB- gene polymorphisms in the linkage-identified MYP6 locus .
18453593	0	csf1r	131,136	CSF-1_receptor	115,129	csf1r	CSF-1 receptor	12978(Tax:10090)	12978(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Ewing_sarcoma protein -LRB- EWS -RRB- binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1_receptor -LRB- csf1r -RRB- gene .
7685657	0	csk	18,21	Src	61,64	csk	Src	12988(Tax:10090)	20779(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Disruption|nmod|gene leads|nsubj|Disruption leads|advcl|encoding encoding|dobj|regulator regulator|nmod|kinases kinases|compound|END_ENTITY	Disruption of the csk gene , encoding a negative regulator of Src family tyrosine kinases , leads to neural tube defects and embryonic_lethality in mice .
7516063	0	csk	58,61	carboxyl-terminal_src_kinase	28,56	csk	carboxyl-terminal src kinase	1445	1445	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning of lsk , a carboxyl-terminal_src_kinase -LRB- csk -RRB- related gene , expressed in leukocytes .
8999872	0	csk-homologous_kinase	15,36	ErbB-2	70,76	csk-homologous kinase	ErbB-2	4145	2064	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association of csk-homologous_kinase -LRB- CHK -RRB- -LRB- formerly MATK -RRB- with HER-2 / ErbB-2 in breast_cancer cells .
8999872	0	csk-homologous_kinase	15,36	HER-2	64,69	csk-homologous kinase	HER-2	4145	2064	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of csk-homologous_kinase -LRB- CHK -RRB- -LRB- formerly MATK -RRB- with HER-2 / ErbB-2 in breast_cancer cells .
19369735	0	ctgf	33,37	Connective_tissue_growth_factor	0,31	ctgf	Connective tissue growth factor	1490	1490	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Connective_tissue_growth_factor -LRB- ctgf -RRB- expression in the tenosynovium of patients with carpal_tunnel_syndrome - biomed 2009 .
20974127	0	ctn	86,89	p120	81,85	ctn	p120	1500	1500	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Ga -LRB- 12 -RRB- binds to the N-terminal regulatory domain of p120 -LRB- ctn -RRB- , and downregulates p120 -LRB- ctn -RRB- tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism .
9515794	0	ctnnb1	32,38	beta-catenin	18,30	ctnnb1	beta-catenin	84353(Tax:10116)	84353(Tax:10116)	Gene	Gene	mutations|amod|START_ENTITY mutations|amod|END_ENTITY	High frequency of beta-catenin -LRB- ctnnb1 -RRB- mutations in the colon_tumors induced by two heterocyclic_amines in the F344 rat .
23390341	0	cubilin	25,32	CUBN	34,38	cubilin	CUBN	8029	8029	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phylogenetic analysis of cubilin -LRB- CUBN -RRB- gene .
9109493	0	cubitus_interruptus	36,55	CBP	11,14	cubitus interruptus	CBP	43767(Tax:7227)	31669(Tax:7227)	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	Drosophila CBP is a co-activator of cubitus_interruptus in hedgehog signalling .
9109493	0	cubitus_interruptus	36,55	hedgehog	59,67	cubitus interruptus	hedgehog	43767(Tax:7227)	42737(Tax:7227)	Gene	Gene	START_ENTITY|nmod|signalling signalling|amod|END_ENTITY	Drosophila CBP is a co-activator of cubitus_interruptus in hedgehog signalling .
21124961	0	cul5	31,35	d-Asb11	23,30	cul5	d-Asb11	327215(Tax:7955)	791758(Tax:7955)	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo .
12481031	0	cullin	30,36	CUL7	0,4	cullin	CUL7	143384	9820	Gene	Gene	binds|nsubj|START_ENTITY END_ENTITY|parataxis|binds	CUL7 : A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex .
10898738	0	cullin	10,16	VACM-1	0,6	cullin	VACM-1	143384	8065	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	VACM-1 , a cullin gene family member , regulates cellular signaling .
9037604	0	cullin	61,67	VACM-1	51,57	cullin	VACM-1	143384	8065	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	Identification and analysis of expression of human VACM-1 , a cullin gene family member located on chromosome 11q22-23 .
11564859	0	cullin_4A	76,85	DDB2	47,51	cullin 4A	DDB2	8451	1643	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin_4A in mammalian cells .
11060247	0	cup	21,24	Nanos	0,5	cup	Nanos	33934(Tax:7227)	42297(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nanos interacts with cup in the female germline of Drosophila .
17277377	0	cup	34,37	nup154	0,6	cup	nup154	33934(Tax:7227)	34527(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	nup154 genetically interacts with cup and plays a cell-type-specific function during Drosophila_melanogaster egg-chamber development .
15115514	0	cutaneous_T-cell_attracting_chemokine	16,53	CTACK	55,60	cutaneous T-cell attracting chemokine	CTACK	10850	10850	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of cutaneous_T-cell_attracting_chemokine -LRB- CTACK -RRB- as a laboratory marker of the severity of atopic_dermatitis in children .
12642842	0	cutaneous_T_cell-attracting_chemokine	16,53	CCL27	55,60	cutaneous T cell-attracting chemokine	CCL27	10850	10850	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increased serum cutaneous_T_cell-attracting_chemokine -LRB- CCL27 -RRB- levels in patients with atopic_dermatitis and psoriasis_vulgaris .
12189248	0	cutaneous_lymphocyte-associated_antigen	14,53	CD8	57,60	cutaneous lymphocyte-associated antigen	CD8	6404	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Expression of cutaneous_lymphocyte-associated_antigen by CD8 -LRB- + -RRB- T cells specific for a skin-tropic virus .
15925831	0	cutaneous_lymphocyte-associated_antigen	14,53	CLA	55,58	cutaneous lymphocyte-associated antigen	CLA	6404	6404	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cutaneous_lymphocyte-associated_antigen -LRB- CLA -RRB- in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis_palmaris et plantaris -LRB- PPP -RRB- .
9865449	0	cutaneous_lymphocyte-associated_antigen	94,133	CLA	89,92	cutaneous lymphocyte-associated antigen	CLA	6404	6404	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Increased numbers of CD68 antigen positive dendritic epidermal cells and upregulation of CLA -LRB- cutaneous_lymphocyte-associated_antigen -RRB- expression on these cells in various skin_diseases .
11093173	0	cutaneous_lymphocyte-associated_antigen	14,53	Th2	81,84	cutaneous lymphocyte-associated antigen	Th2	6404	15111(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of cutaneous_lymphocyte-associated_antigen on human CD4 -LRB- + -RRB- and CD8 -LRB- + -RRB- Th2 cells .
1720810	0	cutaneous_lymphocyte_antigen	4,32	endothelial_cell-leukocyte_adhesion_molecule_1	94,140	cutaneous lymphocyte antigen	endothelial cell-leukocyte adhesion molecule 1	6404	6401	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	The cutaneous_lymphocyte_antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial_cell-leukocyte_adhesion_molecule_1 .
20399856	0	cuticle_protein	45,60	BMWCP10	67,74	cuticle protein	BMWCP10	692409(Tax:7091)	692438(Tax:7091)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Ecdysone directly and indirectly regulates a cuticle_protein gene , BMWCP10 , in the wing disc of Bombyx_mori .
19580866	0	cuticle_protein	79,94	BMWCP5	101,107	cuticle protein	BMWCP5	692409(Tax:7091)	100379326(Tax:7091)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	betaFTZ-F1 and Broad-Complex positively regulate the transcription of the wing cuticle_protein gene , BMWCP5 , in wing discs of Bombyx_mori .
26434741	0	cx43	16,20	Esco2	0,5	cx43	Esco2	30236(Tax:7955)	445395(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Esco2 regulates cx43 expression during skeletal regeneration in the zebrafish fin .
25460567	0	cxcl12	13,19	CXCR4	31,36	cxcl12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY Profiling|nmod|receptors indicates|advcl|Profiling indicates|nsubj|END_ENTITY	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
25460567	0	cxcl12	154,160	CXCR4	31,36	cxcl12	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY cxcr7|nmod|activity role|nmod|cxcr7 indicates|dobj|role indicates|nsubj|END_ENTITY	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
25460567	0	cxcl12	13,19	cxcr7	133,138	cxcl12	cxcr7	20315(Tax:10090)	12778(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY Profiling|nmod|receptors indicates|advcl|Profiling indicates|dobj|role role|nmod|END_ENTITY	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
25460567	0	cxcl12	154,160	cxcr7	133,138	cxcl12	cxcr7	20315(Tax:10090)	12778(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
22273578	0	cxcr4	38,43	CD4	59,62	cxcr4	CD4	7852	12504(Tax:10090)	Gene	Gene	editing|nmod|START_ENTITY promotes|nsubj|editing promotes|dobj|T T|compound|END_ENTITY	Zinc-finger nuclease editing of human cxcr4 promotes HIV-1 CD4 -LRB- + -RRB- T cell resistance and enrichment .
26866290	0	cxcr4	129,134	Jam-a	0,5	cxcr4	Jam-a	7852	50848	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Jam-a is highly expressed on human hematopoietic repopulating cells and associates with the key hematopoietic chemokine receptor cxcr4 .
25460567	0	cxcr7	133,138	cxcl12	13,19	cxcr7	cxcl12	12778(Tax:10090)	20315(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY indicates|dobj|role indicates|advcl|Profiling Profiling|nmod|receptors receptors|amod|END_ENTITY	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
25460567	0	cxcr7	133,138	cxcl12	154,160	cxcr7	cxcl12	12778(Tax:10090)	20315(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Profiling of cxcl12 receptors , CXCR4 and cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for cxcr7 in controlling cxcl12 activity .
22056015	0	cyclic-AMP_responsive_element_modulator	27,66	CREM	68,72	cyclic-AMP responsive element modulator	CREM	1390	1390	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Differential expression of cyclic-AMP_responsive_element_modulator -LRB- CREM -RRB- mRNA isoforms during testicular development of boars .
9881864	0	cyclic-AMP_responsive_element_modulator	41,80	inducible_cyclic-AMP_early_repressor	81,117	cyclic-AMP responsive element modulator	inducible cyclic-AMP early repressor	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Plasticity - and neurodegeneration-linked cyclic-AMP_responsive_element_modulator / inducible_cyclic-AMP_early_repressor messenger RNA expression in the rat brain .
1703775	0	cyclic_AMP	108,118	c-fos	59,64	cyclic AMP	c-fos	12796(Tax:10090)	14281(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Multiple synergistic signal transduction pathways regulate c-fos expression in Swiss_3T3 cells : the role of cyclic_AMP .
22616931	0	cyclic_AMP-response_element-binding_protein	19,62	CREB	64,68	cyclic AMP-response element-binding protein	CREB	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of cyclic_AMP-response_element-binding_protein -LRB- CREB -RRB- is influenced by melatonin treatment in pancreatic rat insulinoma b-cells -LRB- INS-1 -RRB- .
7922574	0	cyclic_AMP-response_element_binding_protein	25,68	CREB	70,74	cyclic AMP-response element binding protein	CREB	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A developmental study of cyclic_AMP-response_element_binding_protein -LRB- CREB -RRB- by in situ hybridization histochemistry and immunocytochemistry in the rat neocortex .
9037515	0	cyclic_AMP-responsive_element_binding_protein	16,61	CREB	63,67	cyclic AMP-responsive element binding protein	CREB	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the cyclic_AMP-responsive_element_binding_protein -LRB- CREB -RRB- in hypoxic-ischemic_brain_damage and repair .
18036509	0	cyclic_AMP_response-element_binding-protein	14,57	CREB	59,63	cyclic AMP response-element binding-protein	CREB	1385	1385	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of cyclic_AMP_response-element_binding-protein -LRB- CREB -RRB- by Gq/11-protein-coupled receptors in human SH-SY5Y neuroblastoma cells .
19050160	0	cyclic_AMP_response_element-binding	58,93	CREB	95,99	cyclic AMP response element-binding	CREB	12912(Tax:10090)	12912(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Spatial memory in the Morris water maze and activation of cyclic_AMP_response_element-binding -LRB- CREB -RRB- protein within the mouse hippocampus .
22269225	0	cyclic_AMP_response_element_binding_protein	58,101	CREB	103,107	cyclic AMP response element binding protein	CREB	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Dysregulated phosphorylation and nuclear translocation of cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- in rat liver after chronic ethanol binge .
8574661	0	cyclic_AMP_response_element_binding_protein	47,90	CREB	92,96	cyclic AMP response element binding protein	CREB	81646(Tax:10116)	81646(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Nitric_oxide induces c-fos gene expression via cyclic_AMP_response_element_binding_protein -LRB- CREB -RRB- phosphorylation in rat retinal_pigment_epithelium .
1850693	0	cyclic_AMP_responsive_element_binding_protein	42,87	TGF-beta_1	0,10	cyclic AMP responsive element binding protein	TGF-beta 1	1385	7040	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	TGF-beta_1 induces phosphorylation of the cyclic_AMP_responsive_element_binding_protein in ML-CCl64 cells .
11451350	0	cyclin	35,41	Androgen_receptor	0,17	cyclin	Androgen receptor	18538(Tax:10090)	367	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Androgen_receptor regulation of G1 cyclin and cyclin-dependent kinase function in the CWR22 human prostate_cancer xenograft .
7896286	0	cyclin	8,14	CCNF	21,25	cyclin	CCNF	5111	899	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel cyclin gene -LRB- CCNF -RRB- in the region of the polycystic_kidney_disease gene -LRB- PKD1 -RRB- .
19237565	0	cyclin	57,63	CDK4	27,31	cyclin	CDK4	5111	1019	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human CDK4 in complex with a D-type cyclin .
11739795	0	cyclin	46,52	CDK6	30,34	cyclin	CDK6	5111	1021	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	CAK-independent activation of CDK6 by a viral cyclin .
11828325	0	cyclin	56,62	CDK6	21,25	cyclin	CDK6	5111	1021	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|basis basis|nmod|END_ENTITY	Structural basis for CDK6 activation by a virus-encoded cyclin .
1534806	0	cyclin	42,48	CYL1	37,41	cyclin	CYL1	5111	12443(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Suppression of growth factor-induced CYL1 cyclin gene expression by antiproliferative agents .
6146981	0	cyclin	70,76	Epidermal_growth_factor	0,23	cyclin	Epidermal growth factor	5111	1950	Gene	Gene	synthesis|nmod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Epidermal_growth_factor inhibits the synthesis of the nuclear protein cyclin in A431 human carcinoma cells .
15855166	0	cyclin	20,26	Hexim1	47,53	cyclin	Hexim1	5111	10614	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat .
7569954	0	cyclin	110,116	KAP	88,91	cyclin	KAP	5111	1033	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin .
8078587	0	cyclin	2,8	MO15	51,55	cyclin	MO15	5111	1022	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	A cyclin associated with the CDK-activating kinase MO15 .
2415394	0	cyclin	20,26	PCNA	28,32	cyclin	PCNA	5111	5111	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	S-phase patterns of cyclin -LRB- PCNA -RRB- antigen staining resemble topographical patterns of DNA synthesis .
2419706	0	cyclin	20,26	PCNA	28,32	cyclin	PCNA	5111	5111	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Nuclear patterns of cyclin -LRB- PCNA -RRB- antigen distribution subdivide S-phase in cultured cells -- some applications of PCNA antibodies .
2889855	0	cyclin	82,88	PCNA	90,94	cyclin	PCNA	5111	5111	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	PCNA -LRB- cyclin -RRB- autoantibodies and monoclonal antibodies reveal similar patterns of cyclin -LRB- PCNA -RRB- antigen staining in human cultured cells .
2884260	0	cyclin	42,48	Proliferating_cell_nuclear_antigen	0,34	cyclin	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- / cyclin in activated human T lymphocytes .
7912140	0	cyclin	35,41	Proliferating_cell_nuclear_antigen	0,34	cyclin	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Proliferating_cell_nuclear_antigen / cyclin expression in small adenomas of the large intestine in relation to size and macroscopic appearance .
8422109	0	cyclin	36,42	Proliferating_cell_nuclear_antigen	0,34	cyclin	Proliferating cell nuclear antigen	5111	5111	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- cyclin -RRB- expression in normal and abnormal cervical squamous_epithelia .
8605306	0	cyclin	111,117	cyclin	84,90	cyclin	cyclin	831001(Tax:3702)	831001(Tax:3702)	Gene	Gene	mutant|nmod|START_ENTITY mutant|compound|END_ENTITY	Isolation of a new mitotic-like cyclin from Arabidopsis : complementation of a yeast cyclin mutant with a plant cyclin .
8605306	0	cyclin	84,90	cyclin	111,117	cyclin	cyclin	831001(Tax:3702)	831001(Tax:3702)	Gene	Gene	mutant|compound|START_ENTITY mutant|nmod|END_ENTITY	Isolation of a new mitotic-like cyclin from Arabidopsis : complementation of a yeast cyclin mutant with a plant cyclin .
22379099	0	cyclin	11,17	cyclin-dependent_kinase-8	27,52	cyclin	cyclin-dependent kinase-8	5111	1024	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Retroviral cyclin enhances cyclin-dependent_kinase-8 activity .
9716181	0	cyclin	64,70	cyclin-dependent_kinase_2	38,63	cyclin	cyclin-dependent kinase 2	5111	1017	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Differential modulation of G1-S-phase cyclin-dependent_kinase_2 / cyclin complexes occurs during the acquisition of a polyploid DNA content .
8668341	0	cyclin	43,49	p21	0,3	cyclin	p21	5111	1026	Gene	Gene	sites|nmod|START_ENTITY contains|dobj|sites contains|nsubj|END_ENTITY	p21 contains independent binding sites for cyclin and cdk2 : both sites are required to inhibit cdk2 kinase activity .
9927425	0	cyclin	38,44	p27	14,17	cyclin	p27	5111	3429	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|levels levels|amod|END_ENTITY	Modulation of p27 -LRB- Kip1 -RRB- levels by the cyclin encoded by Kaposi 's _ sarcoma-associated_herpesvirus .
15271792	0	cyclin	11,17	p27KIP1	27,34	cyclin	p27KIP1	5111	1027	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	KSHV viral cyclin binds to p27KIP1 in primary effusion_lymphomas .
11016654	0	cyclin	21,27	p27Kip1	8,15	cyclin	p27Kip1	5111	1027	Gene	Gene	_|amod|START_ENTITY END_ENTITY|nmod|_	Loss of p27Kip1 from cyclin E/cyclin-dependent _ kinase _ -LRB- CDK -RRB- _ 2 but not from cyclin_D1 / CDK4 complexes in cells transformed by polyamine biosynthetic enzymes .
1968224	0	cyclin	47,53	proliferating_cell_nuclear_antigen	11,45	cyclin	proliferating cell nuclear antigen	34924(Tax:7227)	37290(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Drosophila proliferating_cell_nuclear_antigen -LRB- cyclin -RRB- gene : structure , expression during development , and specific binding of homeodomain proteins to its 5 ' - flanking region .
2564636	0	cyclin	51,57	proliferating_cell_nuclear_antigen	15,49	cyclin	proliferating cell nuclear antigen	394328(Tax:8355)	394328(Tax:8355)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of proliferating_cell_nuclear_antigen -LRB- cyclin -RRB- in DNA replication in living cells .
2571644	0	cyclin	49,55	proliferating_cell_nuclear_antigen	14,48	cyclin	proliferating cell nuclear antigen	5111	5111	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of proliferating_cell_nuclear_antigen / cyclin in human keratinocytes .
2874992	0	cyclin	56,62	proliferating_cell_nuclear_antigen	14,48	cyclin	proliferating cell nuclear antigen	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- / cyclin during the cell cycle .
21746927	0	cyclin-D1	2,11	BAX	29,32	cyclin-D1	BAX	12443(Tax:10090)	12028(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle_cell_lymphoma .
11019942	0	cyclin-D1	5,14	PCNA	16,20	cyclin-D1	PCNA	595	5111	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	p53 , cyclin-D1 , PCNA , AgNOR expression in squamous_cell_cancer_of_the_lip : a multicenter study .
18498074	0	cyclin-D1	31,40	cerbB-2	42,49	cyclin-D1	cerbB-2	595	2064	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Prognostic index expression of cyclin-D1 , cerbB-2 and VEGF : metastases vs corresponding primary cancers and metastatic vs non-metastatic adenocarcinomas .
11019942	0	cyclin-D1	5,14	p53	0,3	cyclin-D1	p53	595	7157	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	p53 , cyclin-D1 , PCNA , AgNOR expression in squamous_cell_cancer_of_the_lip : a multicenter study .
9688185	0	cyclin-D1	123,132	p53	53,56	cyclin-D1	p53	595	7157	Gene	Gene	immunoreactivity|amod|START_ENTITY correlation|nmod|immunoreactivity Expression|dep|correlation Expression|nmod|E2F-1 E2F-1|appos|END_ENTITY	Expression of the cell-cycle-related proteins E2F-1 , p53 , mdm-2 , p21waf-1 , and Ki-67 in multiple myeloma : correlation with cyclin-D1 immunoreactivity .
9466670	0	cyclin-dependent-kinase-4	17,42	CDKN2A	54,60	cyclin-dependent-kinase-4	CDKN2A	1019	1029	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The gene for the cyclin-dependent-kinase-4 inhibitor , CDKN2A , is preferentially deleted in malignant_mesothelioma .
19398314	0	cyclin-dependent_kinase	40,63	CDK1/2	65,71	cyclin-dependent kinase	CDK1/2	69131(Tax:10090)	69131;12534;12566	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	WITHDRAWN : A publisher 's note to `` Novel cyclin-dependent_kinase -LRB- CDK1/2 -RRB- inhibitor induced retinopathy in CD1 and B6C3F1 mice '' This article has been withdrawn at the request of the author -LRB- s -RRB- and/or editor .
23362255	0	cyclin-dependent_kinase	62,85	Pin1	10,14	cyclin-dependent kinase	Pin1	1020	5300	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent_kinase -LRB- Cdk5 -RRB- - dependent Alzheimer phosphorylation sites .
19017637	0	cyclin-dependent_kinase-4	109,134	CDK4	136,140	cyclin-dependent kinase-4	CDK4	1019	1019	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Artemisinin blocks prostate_cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent_kinase-4 -LRB- CDK4 -RRB- promoter and inhibiting CDK4 gene expression .
22379099	0	cyclin-dependent_kinase-8	27,52	cyclin	11,17	cyclin-dependent kinase-8	cyclin	1024	5111	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Retroviral cyclin enhances cyclin-dependent_kinase-8 activity .
23242510	0	cyclin-dependent_kinase-like_5	19,49	CDKL5	51,56	cyclin-dependent kinase-like 5	CDKL5	6792	6792	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations in cyclin-dependent_kinase-like_5 -LRB- CDKL5 -RRB- gene in Indian cases of Rett_syndrome .
26701947	0	cyclin-dependent_kinase-like_5	86,116	CDKL5	118,123	cyclin-dependent kinase-like 5	CDKL5	6792	6792	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Turkish cases of early infantile epileptic_encephalopathy : two novel mutations in the cyclin-dependent_kinase-like_5 -LRB- CDKL5 -RRB- gene .
11161389	0	cyclin-dependent_kinase_1	14,39	CDK1	41,45	cyclin-dependent kinase 1	CDK1	983	983	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- by indirubin derivatives in human tumour cells .
17981370	0	cyclin-dependent_kinase_1	74,99	CDK1	101,105	cyclin-dependent kinase 1	CDK1	983	983	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel 9-oxo-thiazolo -LSB- 5,4-f -RSB- quinazoline-2-carbonitrile derivatives as dual cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- / glycogen synthase kinase-3 -LRB- GSK-3 -RRB- inhibitors : synthesis , biological evaluation and molecular modeling studies .
24013421	0	cyclin-dependent_kinase_1	36,61	Ubp-M	0,5	cyclin-dependent kinase 1	Ubp-M	983	10600	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Ubp-M serine 552 phosphorylation by cyclin-dependent_kinase_1 regulates cell cycle progression .
20368358	0	cyclin-dependent_kinase_1	78,103	mitotic_centromere-associated_kinesin	37,74	cyclin-dependent kinase 1	mitotic centromere-associated kinesin	983	11004	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Functional and spatial regulation of mitotic_centromere-associated_kinesin by cyclin-dependent_kinase_1 .
9618275	0	cyclin-dependent_kinase_1	82,107	p34cdc2	109,116	cyclin-dependent kinase 1	p34cdc2	983	983	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Characterization of the enhancer-like okadaic_acid response element region of the cyclin-dependent_kinase_1 -LRB- p34cdc2 -RRB- promoter .
16888198	0	cyclin-dependent_kinase_1	86,111	secretin	28,36	cyclin-dependent kinase 1	secretin	983	6343	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Retinoic_acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent_kinase_1 .
22298115	0	cyclin-dependent_kinase_10	15,41	CDK10	43,48	cyclin-dependent kinase 10	CDK10	8558	8558	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of the cyclin-dependent_kinase_10 -LRB- CDK10 -RRB- on the tamoxifen sensitivity of keloid samples .
16039607	0	cyclin-dependent_kinase_11	4,30	NOT2	46,50	cyclin-dependent kinase 11	NOT2	23097	4848	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The cyclin-dependent_kinase_11 interacts with NOT2 .
24831015	0	cyclin-dependent_kinase_18	17,43	cyclin_A	82,90	cyclin-dependent kinase 18	cyclin A	5129	890	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	PCTAIRE_kinase_3 / cyclin-dependent_kinase_18 is activated through association with cyclin_A and/or phosphorylation by protein kinase A. PCTAIRE_kinase_3 -LRB- PCTK3 -RRB- / cyclin-dependent_kinase_18 -LRB- CDK18 -RRB- is an uncharacterized member of the CDK family because its activator -LRB- s -RRB- remains unidentified .
19323453	0	cyclin-dependent_kinase_2	83,108	CDK2	110,114	cyclin-dependent kinase 2	CDK2	1017	1017	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Insights into the structural basis of N2 and O6 substituted guanine derivatives as cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- inhibitors : prediction of the binding modes and potency of the inhibitors by docking and ONIOM calculations .
20869873	0	cyclin-dependent_kinase_2	75,100	CDK2	102,106	cyclin-dependent kinase 2	CDK2	1017	1017	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	3D-QSAR and docking studies on pyrazolo -LSB- 4,3-h -RSB- qinazoline-3-carboxamides as cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- inhibitors .
22331465	0	cyclin-dependent_kinase_2	8,33	CDK2	35,39	cyclin-dependent kinase 2	CDK2	12566(Tax:10090)	12566(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Loss of cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication .
17893107	0	cyclin-dependent_kinase_2	47,72	ERK	15,18	cyclin-dependent kinase 2	ERK	362817(Tax:10116)	24338(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The map kinase ERK regulates renal activity of cyclin-dependent_kinase_2 in experimental glomerulonephritis .
10511310	0	cyclin-dependent_kinase_2	46,71	Evi-1	91,96	cyclin-dependent kinase 2	Evi-1	1017	2122	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Loss of cell cycle control by deregulation of cyclin-dependent_kinase_2 kinase activity in Evi-1 transformed fibroblasts .
14985333	0	cyclin-dependent_kinase_2	58,83	beta-catenin	14,26	cyclin-dependent kinase 2	beta-catenin	1017	1499	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|phosphorylation/degradation phosphorylation/degradation|amod|END_ENTITY	Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent_kinase_2 .
9716181	0	cyclin-dependent_kinase_2	38,63	cyclin	64,70	cyclin-dependent kinase 2	cyclin	1017	5111	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	Differential modulation of G1-S-phase cyclin-dependent_kinase_2 / cyclin complexes occurs during the acquisition of a polyploid DNA content .
12615717	0	cyclin-dependent_kinase_2	10,35	cyclin_A	36,44	cyclin-dependent kinase 2	cyclin A	1017	890	Gene	Gene	antagonists|amod|START_ENTITY antagonists|compound|END_ENTITY	Selective cyclin-dependent_kinase_2 / cyclin_A antagonists that differ from ATP site inhibitors block tumor growth .
8443411	0	cyclin-dependent_kinase_2	48,73	cyclin_A	77,85	cyclin-dependent kinase 2	cyclin A	1017	890	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Phosphorylation independent activation of human cyclin-dependent_kinase_2 by cyclin_A in vitro .
9724724	0	cyclin-dependent_kinase_2	25,50	cyclin_A	85,93	cyclin-dependent kinase 2	cyclin A	1017	890	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Substrate recruitment to cyclin-dependent_kinase_2 by a multipurpose docking site on cyclin_A .
15173007	0	cyclin-dependent_kinase_2	48,73	cyclin_a	39,47	cyclin-dependent kinase 2	cyclin a	1017	890	Gene	Gene	complex|amod|START_ENTITY suppresses|nsubj|complex destruction|parataxis|suppresses destruction|nmod|END_ENTITY	Proteasome-mediated destruction of the cyclin_a / cyclin-dependent_kinase_2 complex suppresses tumor cell growth in vitro and in vivo .
15731113	0	cyclin-dependent_kinase_2	77,102	p27	115,118	cyclin-dependent kinase 2	p27	1017	10671	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Regulation of vascular smooth muscle proliferation by heparin : inhibition of cyclin-dependent_kinase_2 activity by p27 -LRB- kip1 -RRB- .
19543928	0	cyclin-dependent_kinase_4	91,116	CDK4	118,122	cyclin-dependent kinase 4	CDK4	1019	1019	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Molecular-docking-guided 3D-QSAR studies of substituted isoquinoline-1 ,3 - -LRB- 2H ,4 H -RRB- - diones as cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- inhibitors .
8811128	0	cyclin-dependent_kinase_4	21,46	CDK4	48,52	cyclin-dependent kinase 4	CDK4	1019	1019	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Amplification of the cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- gene is associated with high cdk4 protein levels in glioblastoma multiforme .
7923152	0	cyclin-dependent_kinase_4	48,73	CDK4I	90,95	cyclin-dependent kinase 4	CDK4I	1019	1019	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rarity of somatic and germline mutations of the cyclin-dependent_kinase_4 inhibitor gene , CDK4I , in melanoma .
10973815	0	cyclin-dependent_kinase_4	14,39	Cdk4	41,45	cyclin-dependent kinase 4	Cdk4	1019	1019	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- by fascaplysin , a marine natural product .
19954867	0	cyclin-dependent_kinase_4	54,79	Cdk4	81,85	cyclin-dependent kinase 4	Cdk4	1019	1019	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Radiosynthesis and radiopharmacological evaluation of cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- inhibitors .
9837900	0	cyclin-dependent_kinase_4	28,53	Cdk4	55,59	cyclin-dependent kinase 4	Cdk4	94201(Tax:10116)	94201(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Calmodulin is essential for cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- activity and nuclear accumulation of cyclin_D1-Cdk4 during G1 .
11358847	0	cyclin-dependent_kinase_4	17,42	cyclin_D2	43,52	cyclin-dependent kinase 4	cyclin D2	1019	894	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Up-regulation of cyclin-dependent_kinase_4 / cyclin_D2 expression but down-regulation of cyclin-dependent_kinase_2 / cyclin E in testicular germ_cell_tumors .
26860827	0	cyclin-dependent_kinase_5	32,57	CDK5	59,63	cyclin-dependent kinase 5	CDK5	1020	1020	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	An immunohistochemical study of cyclin-dependent_kinase_5 -LRB- CDK5 -RRB- expression in non-small cell lung_cancer -LRB- NSCLC -RRB- and small cell lung_cancer -LRB- SCLC -RRB- : a possible prognostic biomarker .
15816873	0	cyclin-dependent_kinase_5	11,36	Cdk5	38,42	cyclin-dependent kinase 5	Cdk5	12568(Tax:10090)	12568(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Control of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity by glutamatergic regulation of p35 stability .
16962740	0	cyclin-dependent_kinase_5	42,67	Cdk5	69,73	cyclin-dependent kinase 5	Cdk5	140908(Tax:10116)	140908(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Prenatal cocaine and morphine alter brain cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity in rat pups .
18388733	0	cyclin-dependent_kinase_5	15,40	Che-1	0,5	cyclin-dependent kinase 5	Che-1	1020	26574	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Che-1 enhances cyclin-dependent_kinase_5 expression and interacts with the active kinase-complex .
11124971	0	cyclin-dependent_kinase_5	13,38	FosB	112,116	cyclin-dependent kinase 5	FosB	12568(Tax:10090)	14282(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|role role|nmod|END_ENTITY	Induction of cyclin-dependent_kinase_5 in the hippocampus by chronic electroconvulsive_seizures : role of -LSB- Delta -RSB- FosB .
17224448	0	cyclin-dependent_kinase_5	50,75	Sept5	30,35	cyclin-dependent kinase 5	Sept5	12568(Tax:10090)	18951(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY Phosphorylation|nmod|interaction Phosphorylation|nmod|END_ENTITY	Phosphorylation of adult type Sept5 -LRB- CDCrel-1 -RRB- by cyclin-dependent_kinase_5 inhibits interaction with syntaxin-1 .
19049962	0	cyclin-dependent_kinase_5	38,63	Tumor_necrosis_factor-alpha	0,27	cyclin-dependent kinase 5	Tumor necrosis factor-alpha	12568(Tax:10090)	21926(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates cyclin-dependent_kinase_5 activity during pain signaling through transcriptional activation of p35 .
15056716	0	cyclin-dependent_kinase_5	178,203	c-Jun_N-terminal_kinase	153,176	cyclin-dependent kinase 5	c-Jun N-terminal kinase	1020	5599	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun_N-terminal_kinase , cyclin-dependent_kinase_5 , and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5 .
14627648	0	cyclin-dependent_kinase_5	10,35	cdk5	37,41	cyclin-dependent kinase 5	cdk5	12568(Tax:10090)	12568(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Decreased cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice .
22889803	0	cyclin-dependent_kinase_5	103,128	cdk5	130,134	cyclin-dependent kinase 5	cdk5	1020	1020	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and structure-activity relationship of 4 - -LRB- 1,3-benzothiazol-2-yl -RRB- - thiophene-2-sulfonamides as cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- / p25 inhibitors .
23000950	0	cyclin-dependent_kinase_5	80,105	nestin	48,54	cyclin-dependent kinase 5	nestin	140908(Tax:10116)	25491(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of intermediate filament protein nestin and its association with cyclin-dependent_kinase_5 in the glomeruli of rats with diabetic_nephropathy .
20033852	0	cyclin-dependent_kinase_5	31,56	p25	14,17	cyclin-dependent kinase 5	p25	140908(Tax:10116)	170496(Tax:10116)	Gene	Gene	activator|amod|START_ENTITY END_ENTITY|appos|activator	Expression of p25 , an aberrant cyclin-dependent_kinase_5 activator , stimulates basal secretion in PC12 cells .
10327200	0	cyclin-dependent_kinase_5	14,39	p35	58,61	cyclin-dependent kinase 5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of cyclin-dependent_kinase_5 and its activator p35 in rat brain after middle_cerebral_artery_occlusion .
10748088	0	cyclin-dependent_kinase_5	50,75	p35	46,49	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent_kinase_5 activator to p25 .
11517264	0	cyclin-dependent_kinase_5	30,55	p35	0,3	cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	function|amod|START_ENTITY essential|nmod|function essential|nsubj|END_ENTITY	p35 and p39 are essential for cyclin-dependent_kinase_5 function during neurodevelopment .
12393264	0	cyclin-dependent_kinase_5	53,78	p35	109,112	cyclin-dependent kinase 5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	activator|nmod|START_ENTITY p35|appos|activator phosphorylation|nmod|p35 Influence|nmod|phosphorylation Influence|nmod|proteolysis proteolysis|nmod|END_ENTITY	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
12393264	0	cyclin-dependent_kinase_5	53,78	p35	32,35	cyclin-dependent kinase 5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
12558997	0	cyclin-dependent_kinase_5	21,46	p35	58,61	cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activator|amod|START_ENTITY activator|appos|END_ENTITY	Stabilization of the cyclin-dependent_kinase_5 activator , p35 , by paclitaxel decreases beta-amyloid toxicity in cortical neurons .
12598607	0	cyclin-dependent_kinase_5	55,80	p35	51,54	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Developmental regulation of the proteolysis of the p35 cyclin-dependent_kinase_5 activator by phosphorylation .
14673209	0	cyclin-dependent_kinase_5	18,43	p35	79,82	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activity|amod|START_ENTITY activity|nmod|metabolism metabolism|nmod|Cdk5 Cdk5|amod|END_ENTITY	The regulation of cyclin-dependent_kinase_5 activity through the metabolism of p35 or p39 Cdk5 activator .
15009685	0	cyclin-dependent_kinase_5	78,103	p35	118,121	cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY independent|nmod|activation causes|dobj|independent causes|nmod|END_ENTITY	Mutant superoxide dismutase 1 causes motor neuron_degeneration independent of cyclin-dependent_kinase_5 activation by p35 or p25 .
15289351	0	cyclin-dependent_kinase_5	106,131	p35	89,92	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	onset|amod|START_ENTITY activator|nmod|onset activator|amod|END_ENTITY	Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent_kinase_5 and consequent onset of the terminal phase of HL60 cell differentiation .
15695523	0	cyclin-dependent_kinase_5	83,108	p35	63,66	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Interferon_gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent_kinase_5 activator via activation of ERK1/2 pathway .
15816873	0	cyclin-dependent_kinase_5	11,36	p35	84,87	cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY Control|nmod|activity Control|nmod|stability stability|amod|END_ENTITY	Control of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity by glutamatergic regulation of p35 stability .
15917097	0	cyclin-dependent_kinase_5	15,40	p35	65,68	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	Association|acl|START_ENTITY activators|nsubj|Association activators|dobj|complex complex|amod|END_ENTITY	Association of cyclin-dependent_kinase_5 and neuronal activators p35 and p39 complex in early-onset Alzheimer 's _ disease .
15992363	0	cyclin-dependent_kinase_5	21,46	p35	54,57	cyclin-dependent kinase 5	p35	140908(Tax:10116)	116671(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|complexes complexes|amod|END_ENTITY	Activation of latent cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- - p35 complexes by membrane dissociation .
15994305	0	cyclin-dependent_kinase_5	41,66	p35	82,85	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	complexed|amod|START_ENTITY tau|nmod|complexed tau|nmod|END_ENTITY	Phosphorylation of FTDP-17 mutant tau by cyclin-dependent_kinase_5 complexed with p35 , p25 , or p39 .
19049962	0	cyclin-dependent_kinase_5	38,63	p35	133,136	cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nmod|pain pain|acl|signaling signaling|nmod|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha regulates cyclin-dependent_kinase_5 activity during pain signaling through transcriptional activation of p35 .
19638632	0	cyclin-dependent_kinase_5	118,143	p35	114,117	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent_kinase_5 activator .
20492361	0	cyclin-dependent_kinase_5	36,61	p35	62,65	cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Actin interaction and regulation of cyclin-dependent_kinase_5 / p35 complex activity .
20518484	0	cyclin-dependent_kinase_5	65,90	p35	102,105	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activators|amod|START_ENTITY activators|amod|END_ENTITY	Membrane association facilitates degradation and cleavage of the cyclin-dependent_kinase_5 activators p35 and p39 .
26966064	0	cyclin-dependent_kinase_5	79,104	p35	146,149	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Transforming_growth_factor-b1 induces cell cycle arrest by activating atypical cyclin-dependent_kinase_5 through up-regulation of Smad3-dependent p35 expression in human MCF10A mammary epithelial cells .
8090221	0	cyclin-dependent_kinase_5	47,72	p35	0,3	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	p35 is a neural-specific regulatory subunit of cyclin-dependent_kinase_5 .
9192293	0	cyclin-dependent_kinase_5	76,101	p35	47,50	cyclin-dependent kinase 5	p35	12568(Tax:10090)	12569(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY patterns|appos|subunit patterns|nmod|expression expression|nmod|END_ENTITY	Temporal and spatial patterns of expression of p35 , a regulatory subunit of cyclin-dependent_kinase_5 , in the nervous system of the mouse .
9727024	0	cyclin-dependent_kinase_5	40,65	p35	0,3	cyclin-dependent kinase 5	p35	1020	8851	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	p35 , the neuronal-specific activator of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- is degraded by the ubiquitin-proteasome pathway .
12699769	0	cyclin-dependent_kinase_5	4,29	p39	41,44	cyclin-dependent kinase 5	p39	12568(Tax:10090)	12570(Tax:10090)	Gene	Gene	activator|amod|START_ENTITY activator|appos|END_ENTITY	The cyclin-dependent_kinase_5 activator , p39 , is expressed in stripes in the mouse cerebellum .
14704270	0	cyclin-dependent_kinase_5	32,57	synaptojanin_1	14,28	cyclin-dependent kinase 5	synaptojanin 1	1020	8867	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of synaptojanin_1 by cyclin-dependent_kinase_5 at synapses .
20847106	0	cyclin-dependent_kinase_5_regulatory_subunit-associated_protein_1-like_1	17,89	CDKAL1	91,97	cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1	CDKAL1	54901	54901	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of a cyclin-dependent_kinase_5_regulatory_subunit-associated_protein_1-like_1 -LRB- CDKAL1 -RRB- polymorphism with elevated hemoglobin A -LRB- c -RRB- levels and the prevalence of metabolic_syndrome in Japanese men : interaction with dietary energy intake .
19437621	0	cyclin-dependent_kinase_5_regulatory_subunit_2	42,88	p39	90,93	cyclin-dependent kinase 5 regulatory subunit 2	p39	8941	8941	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Sp1 and Sp3 regulate transcription of the cyclin-dependent_kinase_5_regulatory_subunit_2 -LRB- p39 -RRB- promoter in neuronal cells .
7759865	0	cyclin-dependent_kinase_6	61,86	PLSTIRE	44,51	cyclin-dependent kinase 6	PLSTIRE	1021	1021	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	Regulation of synthesis and activity of the PLSTIRE protein -LRB- cyclin-dependent_kinase_6 -LRB- cdk6 -RRB- -RRB- , a major cyclin D-associated cdk4 homologue in normal human T lymphocytes .
17208333	0	cyclin-dependent_kinase_6	30,55	beta-catenin	14,26	cyclin-dependent kinase 6	beta-catenin	12571(Tax:10090)	12387(Tax:10090)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of beta-catenin by cyclin-dependent_kinase_6 in Wnt-stimulated cells .
18362169	0	cyclin-dependent_kinase_9	110,135	cyclin_T1	136,145	cyclin-dependent kinase 9	cyclin T1	107951(Tax:10090)	12455(Tax:10090)	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent_kinase_9 / cyclin_T1 complexes .
21555514	0	cyclin-dependent_kinase_9	76,101	cyclin_T1	109,118	cyclin-dependent kinase 9	cyclin T1	1025	904	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent_kinase_9 -LRB- CDK9 -RRB- - cyclin_T1 interaction in Nef-dependent manner .
17130157	0	cyclin-dependent_kinase_inhibitor_1A	34,70	NFI	85,88	cyclin-dependent kinase inhibitor 1A	NFI	1026	4782	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the cyclin-dependent_kinase_inhibitor_1A -LRB- p21 -RRB- gene by NFI in proliferating human cells .
17130157	0	cyclin-dependent_kinase_inhibitor_1A	34,70	p21	72,75	cyclin-dependent kinase inhibitor 1A	p21	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the cyclin-dependent_kinase_inhibitor_1A -LRB- p21 -RRB- gene by NFI in proliferating human cells .
14991744	0	cyclin-dependent_kinase_inhibitor_2A	20,56	CDKN2A	58,64	cyclin-dependent kinase inhibitor 2A	CDKN2A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inactivation of the cyclin-dependent_kinase_inhibitor_2A -LRB- CDKN2A -RRB- gene in squamous_cell_carcinoma of the larynx .
15934315	0	cyclinD1	24,32	WAF1	38,42	cyclinD1	WAF1	595	1026	Gene	Gene	START_ENTITY|appos|p21 p21|appos|END_ENTITY	Expression of survivin , cyclinD1 , p21 -LRB- WAF1 -RRB- , caspase-3 in cervical_cancer and its relation with prognosis .
26387543	0	cyclin_A	58,66	BRCA2	79,84	cyclin A	BRCA2	890	675	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Cyclin_D1 promotes BRCA2-Rad51 interaction by restricting cyclin_A / B-dependent BRCA2 phosphorylation .
9889196	0	cyclin_A	37,45	CDC6	29,33	cyclin A	CDC6	890	990	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of mammalian CDC6 by cyclin_A / CDK2 regulates its subcellular localization .
14572899	0	cyclin_A	19,27	CDK2	106,110	cyclin A	CDK2	890	1017	Gene	Gene	p21|compound|START_ENTITY association|nmod|p21 requires|nsubj|association requires|dobj|region region|compound|END_ENTITY	The association of cyclin_A and cyclin kinase inhibitor p21 in response to gamma-irradiation requires the CDK2 binding region , but not the Cy motif .
14699150	0	cyclin_A	104,112	CDK2	126,130	cyclin A	CDK2	12428(Tax:10090)	12566(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene : induction of cyclin_A and enhanced CDK2 activity .
9889196	0	cyclin_A	37,45	CDK2	46,50	cyclin A	CDK2	890	1017	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphorylation of mammalian CDC6 by cyclin_A / CDK2 regulates its subcellular localization .
7760825	0	cyclin_A	25,33	CREB	101,105	cyclin A	CREB	890	1385	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Cell cycle regulation of cyclin_A gene expression by the cyclic_AMP-responsive transcription factors CREB and CREM .
9578617	0	cyclin_A	22,30	Cdc2	31,35	cyclin A	Cdc2	890	983	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	In vivo regulation of cyclin_A / Cdc2 and cyclin B/Cdc2 through meiotic and early cleavage cycles in starfish .
10095772	0	cyclin_A	18,26	Cdk2	27,31	cyclin A	Cdk2	890	1017	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|sites sites|amod|END_ENTITY	Identification of cyclin_A / Cdk2 phosphorylation sites in B-Myb .
11423988	0	cyclin_A	14,22	Cdk2	23,27	cyclin A	Cdk2	890	1017	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|B-Myb B-Myb|nsubj|impairs impairs|amod|END_ENTITY	Inhibition of cyclin_A / Cdk2 phosphorylation impairs B-Myb transactivation function without affecting interactions with DNA or the CBP coactivator .
15601848	0	cyclin_A	96,104	Cdk2	105,109	cyclin A	Cdk2	890	1017	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Cyclin-dependent kinase activity is required for progesterone_receptor function : novel role for cyclin_A / Cdk2 as a progesterone_receptor coactivator .
15707957	0	cyclin_A	59,67	Cdk2	44,48	cyclin A	Cdk2	890	1017	Gene	Gene	Cdk2|amod|START_ENTITY moiety|nmod|Cdk2 moiety|amod|END_ENTITY	Functional interaction of Puralpha with the Cdk2 moiety of cyclin_A / Cdk2 .
16081423	0	cyclin_A	43,51	Cdk2	52,56	cyclin A	Cdk2	890	1017	Gene	Gene	regulation|nmod|START_ENTITY regulation|parataxis|END_ENTITY	Differential regulation of CDP/Cux p110 by cyclin_A / Cdk2 and cyclin_A / Cdk1 .
19858290	0	cyclin_A	65,73	Cdk2	74,78	cyclin A	Cdk2	890	1017	Gene	Gene	element|nmod|START_ENTITY element|dep|END_ENTITY	A bifunctional regulatory element in human somatic Wee1 mediates cyclin_A / Cdk2 binding and Crm1-dependent nuclear export .
9294175	0	cyclin_A	67,75	Cdk2	76,80	cyclin A	Cdk2	890	1017	Gene	Gene	START_ENTITY|amod|complex complex|nmod:npmod|END_ENTITY	Regulation of estrogen_receptor transcriptional enhancement by the cyclin_A / Cdk2 complex .
25483089	0	cyclin_A	98,106	Cdt1	92,96	cyclin A	Cdt1	890	81620	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of the p12 subunit of human DNA polymerase -LRB- Pol -RRB- , CDK inhibitor p21 -LRB- WAF1 -RRB- , Cdt1 , cyclin_A , PCNA and Ki-67 in relation to DNA replication in individual cells .
26387543	0	cyclin_A	58,66	Cyclin_D1	0,9	cyclin A	Cyclin D1	890	595	Gene	Gene	phosphorylation|compound|START_ENTITY restricting|dobj|phosphorylation promotes|advcl|restricting promotes|nsubj|END_ENTITY	Cyclin_D1 promotes BRCA2-Rad51 interaction by restricting cyclin_A / B-dependent BRCA2 phosphorylation .
10329431	0	cyclin_A	69,77	E2F1	90,94	cyclin A	E2F1	890	1869	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
10329431	0	cyclin_A	95,103	E2F1	90,94	cyclin A	E2F1	890	1869	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
18285455	0	cyclin_A	39,47	FoxM1	14,19	cyclin A	FoxM1	890	2305	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of FoxM1 during G2 requires cyclin_A / Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain .
23259573	0	cyclin_A	56,64	HuR	0,3	cyclin A	HuR	890	1994	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|compound|END_ENTITY	HuR cytoplasmic expression is associated with increased cyclin_A expression and poor outcome with upper_urinary_tract_urothelial_carcinoma .
23889148	0	cyclin_A	56,64	HuR	0,3	cyclin A	HuR	890	1994	Gene	Gene	expression|compound|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|compound|END_ENTITY	HuR cytoplasmic expression is associated with increased cyclin_A expression and inferior disease-free survival in patients with gastrointestinal_stromal_tumours -LRB- GISTs -RRB- .
16491347	0	cyclin_A	45,53	PCNA	55,59	cyclin A	PCNA	890	5111	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
11237594	0	cyclin_A	32,40	Sp1	14,17	cyclin A	Sp1	890	6667	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modulation of Sp1 activity by a cyclin_A / CDK complex .
12383116	0	cyclin_A	152,160	WAF1	18,22	cyclin A	WAF1	890	1026	Gene	Gene	p21|nmod|START_ENTITY p21|appos|END_ENTITY	Highly potent p21 -LRB- WAF1 -RRB- - derived peptide inhibitors of CDK-mediated pRb phosphorylation : delineation and structural insight into their interactions with cyclin_A .
12105198	0	cyclin_A	51,59	calpain_3	63,72	cyclin A	calpain 3	12428(Tax:10090)	12335(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY required|nmod|cleavage required|nmod|END_ENTITY	C/EBPalpha is required for proteolytic cleavage of cyclin_A by calpain_3 in myeloid precursor cells .
1653904	0	cyclin_A	50,58	cdk2	23,27	cyclin A	cdk2	890	1017	Gene	Gene	p33|amod|START_ENTITY encodes|dobj|p33 gene|acl:relcl|encodes gene|amod|END_ENTITY	Isolation of the human cdk2 gene that encodes the cyclin_A - and adenovirus E1A-associated p33 kinase .
7799940	0	cyclin_A	82,90	cdk2	91,95	cyclin A	cdk2	890	1017	Gene	Gene	/|compound|START_ENTITY binding|nmod|/ END_ENTITY|amod|binding	The Rb-related p107 protein can suppress E2F function independently of binding to cyclin_A / cdk2 .
24831015	0	cyclin_A	82,90	cyclin-dependent_kinase_18	17,43	cyclin A	cyclin-dependent kinase 18	890	5129	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	PCTAIRE_kinase_3 / cyclin-dependent_kinase_18 is activated through association with cyclin_A and/or phosphorylation by protein kinase A. PCTAIRE_kinase_3 -LRB- PCTK3 -RRB- / cyclin-dependent_kinase_18 -LRB- CDK18 -RRB- is an uncharacterized member of the CDK family because its activator -LRB- s -RRB- remains unidentified .
12615717	0	cyclin_A	36,44	cyclin-dependent_kinase_2	10,35	cyclin A	cyclin-dependent kinase 2	890	1017	Gene	Gene	antagonists|compound|START_ENTITY antagonists|amod|END_ENTITY	Selective cyclin-dependent_kinase_2 / cyclin_A antagonists that differ from ATP site inhibitors block tumor growth .
8443411	0	cyclin_A	77,85	cyclin-dependent_kinase_2	48,73	cyclin A	cyclin-dependent kinase 2	890	1017	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Phosphorylation independent activation of human cyclin-dependent_kinase_2 by cyclin_A in vitro .
9724724	0	cyclin_A	85,93	cyclin-dependent_kinase_2	25,50	cyclin A	cyclin-dependent kinase 2	890	1017	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Substrate recruitment to cyclin-dependent_kinase_2 by a multipurpose docking site on cyclin_A .
10329431	0	cyclin_A	69,77	cyclin_A	95,103	cyclin A	cyclin A	890	890	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
10329431	0	cyclin_A	95,103	cyclin_A	69,77	cyclin A	cyclin A	890	890	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
19624419	0	cyclin_A	52,60	cyclin_D1	41,50	cyclin A	cyclin D1	890	595	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
10329431	0	cyclin_A	202,210	p107	197,201	cyclin A	p107	890	5933	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
1532457	0	cyclin_A	25,33	p107	15,19	cyclin A	p107	890	5933	Gene	Gene	independent|compound|START_ENTITY END_ENTITY|nmod|independent	Interaction of p107 with cyclin_A independent of complex_formation_with_viral_oncoproteins .
19624419	0	cyclin_A	52,60	p16	72,75	cyclin A	p16	890	1029	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
10936682	0	cyclin_A	32,40	p21	62,65	cyclin A	p21	890	1026	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|expression expression|amod|END_ENTITY	Failure to induce inhibition of cyclin_A and up-regulation of p21 expression in phorbol_ester-resistant U937 cells by phorbol_ester .
16491347	0	cyclin_A	45,53	p21	92,95	cyclin A	p21	890	1026	Gene	Gene	Ki67|dep|START_ENTITY Ki67|amod|inhibitors inhibitors|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
19624419	0	cyclin_A	52,60	p21	67,70	cyclin A	p21	890	1026	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
25483089	0	cyclin_A	98,106	p21	81,84	cyclin A	p21	890	1026	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|CDK CDK|dep|END_ENTITY	Expression of the p12 subunit of human DNA polymerase -LRB- Pol -RRB- , CDK inhibitor p21 -LRB- WAF1 -RRB- , Cdt1 , cyclin_A , PCNA and Ki-67 in relation to DNA replication in individual cells .
11706071	0	cyclin_A	128,136	p27	18,21	cyclin A	p27	890	3429	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|nmod|protein protein|amod|END_ENTITY	Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin_A and cyclin_B1 in diffuse_large_B-cell_lymphomas .
14747563	0	cyclin_A	48,56	p27	57,60	cyclin A	p27	890	10671	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Epstein-Barr_virus nuclear antigen 3C regulates cyclin_A / p27 complexes and enhances cyclin_A-dependent kinase activity .
16491347	0	cyclin_A	45,53	p27	97,100	cyclin A	p27	890	3429	Gene	Gene	Ki67|dep|START_ENTITY Ki67|amod|inhibitors inhibitors|dep|p21 p21|nummod|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
19624419	0	cyclin_A	52,60	p27	62,65	cyclin A	p27	890	3429	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
9860976	0	cyclin_A	91,99	p27	38,41	cyclin A	p27	890	3429	Gene	Gene	cleavage|nmod|START_ENTITY induces|dobj|cleavage induces|nsubj|END_ENTITY	The cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- induces N-terminal proteolytic cleavage of cyclin_A .
16774918	0	cyclin_A	69,77	p27Kip1	97,104	cyclin A	p27Kip1	890	1027	Gene	Gene	protects|dobj|START_ENTITY protects|nmod|END_ENTITY	Skp2 contains a novel cyclin_A binding domain that directly protects cyclin_A from inhibition by p27Kip1 .
11606707	0	cyclin_A	21,29	roughex	46,53	cyclin A	roughex	39340(Tax:7227)	31535(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Rapid evolution of a cyclin_A inhibitor gene , roughex , in Drosophila .
9268374	0	cyclin_A	23,31	transforming_growth_factor-beta1	44,76	cyclin A	transforming growth factor-beta1	890	7040	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Down-regulation of the cyclin_A promoter by transforming_growth_factor-beta1 is associated with a reduction in phosphorylated activating_transcription_factor-1 and cyclic_AMP-responsive element-binding protein .
15215197	0	cyclin_A1	30,39	Ccna1	46,51	cyclin A1	Ccna1	12427(Tax:10090)	12427(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Distinct regions of the mouse cyclin_A1 gene , Ccna1 , confer male germ-cell specific expression and enhancer function .
10926775	0	cyclin_A1	11,20	MPF	42,45	cyclin A1	MPF	12427(Tax:10090)	56047(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	A role for cyclin_A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice .
23602554	0	cyclin_A2	29,38	CDK1	39,43	cyclin A2	CDK1	890	983	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
23602554	0	cyclin_A2	29,38	CDK1	39,43	cyclin A2	CDK1	890	983	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
23602554	0	cyclin_A2	29,38	SAMHD1	19,25	cyclin A2	SAMHD1	890	25939	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
23602554	0	cyclin_A2	29,38	SAMHD1	19,25	cyclin A2	SAMHD1	890	25939	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of SAMHD1 by cyclin_A2 / CDK1 regulates its restriction activity toward HIV-1 .
15805267	0	cyclin_A2	30,39	p120E4F	83,90	cyclin A2	p120E4F	890	1877	Gene	Gene	regulation|nmod|START_ENTITY Transcriptional|dobj|regulation Transcriptional|nmod|enhanced enhanced|nmod|END_ENTITY	Transcriptional regulation of cyclin_A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin_A2 promoter .
15805267	0	cyclin_A2	98,107	p120E4F	83,90	cyclin A2	p120E4F	890	1877	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Transcriptional regulation of cyclin_A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin_A2 promoter .
24574517	0	cyclin_B1	107,116	Akt	132,135	cyclin B1	Akt	891	207	Gene	Gene	expression|amod|START_ENTITY expression|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Androgen_receptor promotes the oncogenic function of overexpressed Jagged1 in prostate_cancer by enhancing cyclin_B1 expression via Akt phosphorylation .
24147952	0	cyclin_B1	71,80	C-myc	87,92	cyclin B1	C-myc	891	4609	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
1386686	0	cyclin_B1	6,15	CCNB1	22,27	cyclin B1	CCNB1	891	891	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human cyclin_B1 gene -LRB- CCNB1 -RRB- assigned to chromosome 5 -LRB- q13-qter -RRB- .
11139145	0	cyclin_B1	25,34	CDK1	66,70	cyclin B1	CDK1	25203(Tax:10116)	54237(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Developmental changes in cyclin_B1 and cyclin-dependent_kinase_1 -LRB- CDK1 -RRB- levels in the different populations of spermatogenic cells of the post-natal rat testis .
21051949	0	cyclin_B1	33,42	CDK1	43,47	cyclin B1	CDK1	891	983	Gene	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	FGF inhibits the activity of the cyclin_B1 / CDK1 kinase to induce a transient G arrest in RCS chondrocytes .
16102754	0	cyclin_B1	58,67	Cdc2	68,72	cyclin B1	Cdc2	268697(Tax:10090)	12534(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Kr __ ppel-like_factor_5 promotes mitosis by activating the cyclin_B1 / Cdc2 complex during oncogenic Ras-mediated transformation .
21918689	0	cyclin_B1	8,17	Cdc2	18,22	cyclin B1	Cdc2	891	983	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Role of cyclin_B1 / Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast_cancer cells treated with nocodazole .
15215233	0	cyclin_B1	86,95	Cdk1	96,100	cyclin B1	Cdk1	891	983	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Regulation of activation-induced Fas -LRB- CD95/Apo -1 -RRB- ligand expression in T cells by the cyclin_B1 / Cdk1 complex .
25107587	0	cyclin_B1	101,110	Cdk1	111,115	cyclin B1	Cdk1	891	983	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	MJ-66 induces malignant_glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin_B1 / Cdk1 complex .
10716937	0	cyclin_B1	47,56	Cyclin_F	0,8	cyclin B1	Cyclin F	891	899	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Cyclin_F regulates the nuclear localization of cyclin_B1 through a cyclin-cyclin interaction .
12379461	0	cyclin_B1	24,33	H-ras	10,15	cyclin B1	H-ras	891	3265	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Oncogenic H-ras induces cyclin_B1 expression in a p53-independent manner .
20965177	0	cyclin_B1	20,29	Hip2	0,4	cyclin B1	Hip2	891	3093	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Hip2 interacts with cyclin_B1 and promotes its degradation through the ubiquitin proteasome pathway .
24147952	0	cyclin_B1	71,80	IMP1	60,64	cyclin B1	IMP1	891	10642	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
21174181	0	cyclin_B1	35,44	INK4A	100,105	cyclin B1	INK4A	891	1029	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein expression|appos|END_ENTITY	Aberrant cytoplasmic expression of cyclin_B1 protein and its correlation with EBV-LMP1 , P53 and P16 -LRB- INK4A -RRB- in classical Hodgkin_lymphoma in China .
24147952	0	cyclin_B1	71,80	P16	66,69	cyclin B1	P16	891	1029	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	cyclin_B1	71,80	P53	55,58	cyclin B1	P53	891	7157	Gene	Gene	Survivn|appos|START_ENTITY Survivn|compound|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
24147952	0	cyclin_B1	71,80	P62	82,85	cyclin B1	P62	891	23636	Gene	Gene	Survivn|appos|START_ENTITY Survivn|appos|END_ENTITY	Autoantibody detection to tumor-associated antigens of P53 , IMP1 , P16 , cyclin_B1 , P62 , C-myc , Survivn , and Koc for the screening of high-risk subjects and early detection of esophageal_squamous_cell_carcinoma .
11331587	0	cyclin_B1	24,33	Patched1	0,8	cyclin B1	Patched1	891	5727	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Patched1 interacts with cyclin_B1 to regulate cell cycle progression .
11242082	0	cyclin_B1	34,43	Polo-like_kinase_1	0,18	cyclin B1	Polo-like kinase 1	379888(Tax:8355)	380481(Tax:8355)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Polo-like_kinase_1 phosphorylates cyclin_B1 and targets it to the nucleus during prophase .
22266860	0	cyclin_B1	49,58	Sp1	0,3	cyclin B1	Sp1	891	6667	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Sp1 phosphorylation by cyclin-dependent_kinase_1 / cyclin_B1 represses its DNA-binding activity during mitosis in cancer cells .
9105418	0	cyclin_B1	103,112	cyclin_B1	75,84	cyclin B1	cyclin B1	891	891	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Immortal , non-tumourigenic mouse mammary outgrowths express high levels of cyclin_B1 and activation of cyclin_B1 / cdc2 kinase .
9105418	0	cyclin_B1	75,84	cyclin_B1	103,112	cyclin B1	cyclin B1	891	891	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Immortal , non-tumourigenic mouse mammary outgrowths express high levels of cyclin_B1 and activation of cyclin_B1 / cdc2 kinase .
9923075	0	cyclin_B1	83,92	cyclin_B2	61,70	cyclin B1	cyclin B2	379888(Tax:8355)	397743(Tax:8355)	Gene	Gene	not|nmod|START_ENTITY END_ENTITY|dep|not	Overexpression of the cytoplasmic_retention_signal region of cyclin_B2 , but not of cyclin_B1 , inhibits bipolar spindle formation in Xenopus oocytes .
23874748	0	cyclin_B1	18,27	miR-379	0,7	cyclin B1	miR-379	891	494328	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-379 regulates cyclin_B1 expression and is decreased in breast_cancer .
16426843	0	cyclin_B1	74,83	p21	47,50	cyclin B1	p21	25203(Tax:10116)	24525(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin_B1 expression in a p53-independent manner .
9164677	0	cyclin_B1	188,197	p34cdc2	198,205	cyclin B1	p34cdc2	891	983	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Mechanism of action of a tyrphostin , _ 3,4-dihydroxy-alpha-cyanothiocinnamamide , in breast_cancer cell growth inhibition involves the suppression of cyclin_B1 and the functional activity of cyclin_B1 / p34cdc2 complex .
10051609	0	cyclin_B1	38,47	p53	0,3	cyclin B1	p53	891	7157	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p53 regulates a G2 checkpoint through cyclin_B1 .
12009577	0	cyclin_B1	22,31	p53	134,137	cyclin B1	p53	891	7157	Gene	Gene	recognition|nmod|START_ENTITY result|nsubj|recognition result|acl:relcl|caused caused|nmod|END_ENTITY	Immune recognition of cyclin_B1 as a tumor antigen is a result of its overexpression in human tumors that is caused by non-functional p53 .
15710382	0	cyclin_B1	63,72	p53	0,3	cyclin B1	p53	891	7157	Gene	Gene	transcription|amod|START_ENTITY repressor|nmod|transcription repressor|nsubj|END_ENTITY	p53 is a NF-Y - and p21-independent , Sp1-dependent repressor of cyclin_B1 transcription .
19223507	0	cyclin_B1	29,38	p53	92,95	cyclin B1	p53	891	7157	Gene	Gene	responses|nmod|START_ENTITY responses|nmod|tumors tumors|acl|overexpressing overexpressing|dobj|END_ENTITY	CD8 T-cell responses against cyclin_B1 in breast_cancer patients with tumors overexpressing p53 .
19769738	0	cyclin_B1	17,26	p53	104,107	cyclin B1	p53	268697(Tax:10090)	22060(Tax:10090)	Gene	Gene	delays|amod|START_ENTITY Immunity|nmod|delays development|amod|Immunity development|nmod|tumors tumors|nmod|END_ENTITY	Immunity against cyclin_B1 tumor antigen delays development of spontaneous cyclin_B1-positive tumors in p53 -LRB- - / - -RRB- mice .
25982682	0	cyclin_B1	62,71	p53	89,92	cyclin B1	p53	891	7157	Gene	Gene	independently|nmod:npmod|START_ENTITY function|advmod|independently function|compound|END_ENTITY	Germ_cell_tumors overexpress the candidate therapeutic target cyclin_B1 independently of p53 function .
25982682	0	cyclin_B1	62,71	p53	89,92	cyclin B1	p53	891	7157	Gene	Gene	independently|nmod:npmod|START_ENTITY function|advmod|independently function|compound|END_ENTITY	Germ_cell_tumors overexpress the candidate therapeutic target cyclin_B1 independently of p53 function .
15737644	0	cyclin_B1	53,62	p73	0,3	cyclin B1	p73	891	7161	Gene	Gene	transcription|amod|START_ENTITY repressor|nmod|transcription repressor|nsubj|END_ENTITY	p73 is a p53-independent , Sp1-dependent repressor of cyclin_B1 transcription .
12447691	0	cyclin_B1	115,124	polo-like_kinase_1	54,72	cyclin B1	polo-like kinase 1	891	5347	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|phosphorylation phosphorylation|nmod|activity activity|nmod|END_ENTITY	Cooperative phosphorylation including the activity of polo-like_kinase_1 regulates the subcellular localization of cyclin_B1 .
17974570	0	cyclin_B1	37,46	separase	78,86	cyclin B1	separase	891	9700	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Phosphorylation-dependent binding of cyclin_B1 to a Cdc6-like domain of human separase .
9923075	0	cyclin_B2	61,70	cyclin_B1	83,92	cyclin B2	cyclin B1	397743(Tax:8355)	379888(Tax:8355)	Gene	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	Overexpression of the cytoplasmic_retention_signal region of cyclin_B2 , but not of cyclin_B1 , inhibits bipolar spindle formation in Xenopus oocytes .
8730095	0	cyclin_C	37,45	Cdk8	11,15	cyclin C	Cdk8	892	856065(Tax:4932)	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Drosophila Cdk8 , a kinase partner of cyclin_C that interacts with the large subunit of RNA polymerase II .
14576155	0	cyclin_D1	101,110	AKT	0,3	cyclin D1	AKT	595	207	Gene	Gene	expression|amod|START_ENTITY regulating|dobj|expression mammalian_target_of_rapamycin|advcl|regulating determines|advcl|mammalian_target_of_rapamycin determines|nsubj|activity activity|compound|END_ENTITY	AKT activity determines sensitivity to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors by regulating cyclin_D1 and c-myc expression .
21135252	0	cyclin_D1	15,24	AP-1	0,4	cyclin D1	AP-1	595	3725	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	AP-1 regulates cyclin_D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition : role of AIP4/Itch-mediated JUNB degradation .
11375399	0	cyclin_D1	74,83	Activating_transcription_factor_3	0,33	cyclin D1	Activating transcription factor 3	12443(Tax:10090)	11910(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Activating_transcription_factor_3 induces DNA synthesis and expression of cyclin_D1 in hepatocytes .
10910956	0	cyclin_D1	72,81	Akt	126,129	cyclin D1	Akt	58919(Tax:10116)	24185(Tax:10116)	Gene	Gene	stabilization|amod|START_ENTITY stabilization|acl|associated associated|nmod|activation activation|nmod|END_ENTITY	A potential mechanism for fumonisin_B -LRB- 1 -RRB- - mediated hepatocarcinogenesis : cyclin_D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity .
16443763	0	cyclin_D1	50,59	Akt	0,3	cyclin D1	Akt	12443(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY induces|advcl|regulating induces|nsubj|END_ENTITY	Akt induces beta-cell proliferation by regulating cyclin_D1 , cyclin_D2 , and p21 levels and cyclin-dependent_kinase-4 activity .
17370311	0	cyclin_D1	129,138	Akt	6,9	cyclin D1	Akt	595	207	Gene	Gene	induction|nmod|START_ENTITY plays|nmod|induction plays|nsubj|signal signal|compound|END_ENTITY	PI-3K / Akt signal pathway plays a crucial role in arsenite-induced cell proliferation of human keratinocytes through induction of cyclin_D1 .
17935714	0	cyclin_D1	77,86	Akt	105,108	cyclin D1	Akt	595	207	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Abrogation of p53 by its antisense in MCF-7 breast_carcinoma cells increases cyclin_D1 via activation of Akt and promotion of cell proliferation .
18197291	0	cyclin_D1	28,37	Akt	6,9	cyclin D1	Akt	595	207	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	PI-3K / Akt pathway-dependent cyclin_D1 expression is responsible for arsenite-induced human keratinocyte transformation .
18562319	0	cyclin_D1	53,62	Akt	119,122	cyclin D1	Akt	595	207	Gene	Gene	function|amod|START_ENTITY regulates|dobj|function regulates|nmod|signaling signaling|compound|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_A1 regulates cyclin_D1 and c-myc internal ribosome entry site function through Akt signaling .
18769147	0	cyclin_D1	95,104	Akt	47,50	cyclin D1	Akt	595	207	Gene	Gene	stability|amod|START_ENTITY enhance|dobj|stability activation|acl|enhance activation|amod|crossroad crossroad|nmod|END_ENTITY	GSK-3beta inhibition : at the crossroad between Akt and mTOR constitutive activation to enhance cyclin_D1 protein stability in mantle_cell_lymphoma .
24044882	0	cyclin_D1	98,107	Akt	23,26	cyclin D1	Akt	595	207	Gene	Gene	inhibition|nmod|START_ENTITY arrest|nmod|inhibition promotes|dep|arrest promotes|nsubj|Molecular Molecular|acl|targeting targeting|nmod|END_ENTITY	Molecular targeting of Akt by thymoquinone promotes G -LRB- 1 -RRB- arrest through translation inhibition of cyclin_D1 and induces apoptosis in breast_cancer cells .
10645009	0	cyclin_D1	32,41	B-Myb	14,19	cyclin D1	B-Myb	595	4605	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of B-Myb activity by cyclin_D1 .
17670745	0	cyclin_D1	68,77	BAD	49,52	cyclin D1	BAD	595	572	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Breast_cancer cell proliferation is inhibited by BAD : regulation of cyclin_D1 .
15711060	0	cyclin_D1	69,78	Basic_fibroblast_growth_factor	0,30	cyclin D1	Basic fibroblast growth factor	58919(Tax:10116)	54250(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY exhibits|dobj|regulation exhibits|nsubj|END_ENTITY	Basic_fibroblast_growth_factor exhibits dual and rapid regulation of cyclin_D1 and p27 to stimulate proliferation of rat cerebral cortical precursors .
25225463	0	cyclin_D1	113,122	Bcl2	53,57	cyclin D1	Bcl2	595	596	Gene	Gene	epidermal|amod|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
10201372	0	cyclin_D1	37,46	Beta-catenin	0,12	cyclin D1	Beta-catenin	595	1499	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Beta-catenin regulates expression of cyclin_D1 in colon_carcinoma cells .
10759547	0	cyclin_D1	72,81	Beta-catenin	0,12	cyclin D1	Beta-catenin	595	1499	Gene	Gene	expression|amod|START_ENTITY roles|nmod|expression END_ENTITY|dep|roles	Beta-catenin , a novel prognostic marker for breast_cancer : its roles in cyclin_D1 expression and cancer progression .
15111320	0	cyclin_D1	96,105	Beta-catenin	0,12	cyclin D1	Beta-catenin	595	1499	Gene	Gene	pathway|nmod|START_ENTITY activation|nmod|pathway induces|dobj|activation induces|nsubj|END_ENTITY	Beta-catenin simultaneously induces activation of the p53-p21WAF1 pathway and overexpression of cyclin_D1 during squamous differentiation of endometrial_carcinoma cells .
16740029	0	cyclin_D1	48,57	Beta-catenin	0,12	cyclin D1	Beta-catenin	595	1499	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|amod|END_ENTITY	Beta-catenin nuclear expression correlates with cyclin_D1 expression in primary and metastatic synovial_sarcoma : a tissue microarray study .
16267018	0	cyclin_D1	19,28	Bombesin	0,8	cyclin D1	Bombesin	595	2922	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Bombesin regulates cyclin_D1 expression through the early_growth_response_protein Egr-1 in prostate_cancer cells .
12557224	0	cyclin_D1	43,52	CCND1	54,59	cyclin D1	CCND1	595	595	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Rearrangements and increased expression of cyclin_D1 -LRB- CCND1 -RRB- in neuroblastoma .
16829689	0	cyclin_D1	18,27	CCND1	29,34	cyclin D1	CCND1	595	595	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The effect of the cyclin_D1 -LRB- CCND1 -RRB- A870G polymorphism on colorectal_cancer risk is modified by glutathione-S-transferase polymorphisms and isothiocyanate intake in the Singapore Chinese Health Study .
23873109	0	cyclin_D1	4,13	CCND1	15,20	cyclin D1	CCND1	595	595	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The cyclin_D1 -LRB- CCND1 -RRB- G870A polymorphism and lung_cancer susceptibility : a meta-analysis .
25227811	0	cyclin_D1	2,11	CCND1	13,18	cyclin D1	CCND1	595	595	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	A cyclin_D1 -LRB- CCND1 -RRB- gene polymorphism contributes to susceptibility to papillary_thyroid_cancer in the Turkish population .
8562333	0	cyclin_D1	34,43	CCND1	27,32	cyclin D1	CCND1	595	595	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of CCND1 -LRB- cyclin_D1 -RRB- overexpression in primary resected non-small-cell_lung_cancer .
9813719	0	cyclin_D1	58,67	CCND1	51,56	cyclin D1	CCND1	595	595	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A differential PCR system for the determination of CCND1 -LRB- cyclin_D1 -RRB- gene amplification in head_and_neck_squamous_cell_carcinomas .
26619106	0	cyclin_D1	25,34	CD99	0,4	cyclin D1	CD99	595	4267	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	CD99 correlates with low cyclin_D1 , high topoisomerase 2 status and triple negative molecular phenotype but is prognostically irrelevant in breast_carcinoma .
10390005	0	cyclin_D1	40,49	CDK4	103,107	cyclin D1	CDK4	595	1019	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|that that|nmod|cyclin-dependent_kinase_4 cyclin-dependent_kinase_4|appos|END_ENTITY	Comparison of deregulated expression of cyclin_D1 and cyclin E with that of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and CDK2 in human oesophageal_squamous_cell_carcinoma .
10398121	0	cyclin_D1	72,81	CDK4	83,87	cyclin D1	CDK4	595	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
11016654	0	cyclin_D1	75,84	CDK4	85,89	cyclin D1	CDK4	595	1019	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	Loss of p27Kip1 from cyclin E/cyclin-dependent _ kinase _ -LRB- CDK -RRB- _ 2 but not from cyclin_D1 / CDK4 complexes in cells transformed by polyamine biosynthetic enzymes .
11798599	0	cyclin_D1	27,36	CDK4	37,41	cyclin D1	CDK4	595	1019	Gene	Gene	-LSB-|nmod|START_ENTITY END_ENTITY|dep|-LSB-	-LSB- The effect of bombesin on cyclin_D1 / CDK4 of immortalized human gastric epithelial cell line -RSB- .
12657252	0	cyclin_D1	70,79	CDK4	80,84	cyclin D1	CDK4	595	1019	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Synthesis of quinolinyl/isoquinolinyl -LSB- a -RSB- pyrrolo _ -LSB- 3,4-c -RSB- _ carbazoles as cyclin_D1 / CDK4 inhibitors .
12824014	0	cyclin_D1	28,37	CDK4	38,42	cyclin D1	CDK4	595	1019	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel , potent and selective cyclin_D1 / CDK4 inhibitors : indolo -LSB- 6,7-a -RSB- pyrrolo -LSB- 3,4-c -RSB- carbazoles .
15104433	0	cyclin_D1	70,79	CDK4	80,84	cyclin D1	CDK4	595	1019	Gene	Gene	START_ENTITY|parataxis|inhibitors inhibitors|nsubj|END_ENTITY	Synthetic approaches to indolo -LSB- 6,7-a -RSB- pyrrolo -LSB- 3,4-c -RSB- carbazoles : potent cyclin_D1 / CDK4 inhibitors .
15221443	0	cyclin_D1	25,34	CDK4	35,39	cyclin D1	CDK4	595	1019	Gene	Gene	Pattern|nmod|START_ENTITY Pattern|dep|END_ENTITY	Pattern of expression of cyclin_D1 / CDK4 complex in human placenta during gestation .
16294008	0	cyclin_D1	67,76	CDK4	49,53	cyclin D1	CDK4	449028(Tax:9615)	481131(Tax:9615)	Gene	Gene	activated|nmod|START_ENTITY END_ENTITY|acl|activated	Distinct specificities of pRb phosphorylation by CDK4 activated by cyclin_D1 or cyclin_D3 : differential involvement in the distinct mitogenic modes of thyroid epithelial cells .
16319987	0	cyclin_D1	126,135	CDK4	24,28	cyclin D1	CDK4	595	1019	Gene	Gene	inhibition|amod|START_ENTITY overexpression|nmod|inhibition Effect|nmod|overexpression END_ENTITY|dep|Effect	Validation of cyclin_D1 / CDK4 as an anticancer drug target in MCF-7 breast_cancer cells : Effect of regulated overexpression of cyclin_D1 and siRNA-mediated inhibition of endogenous cyclin_D1 and CDK4 expression .
16319987	0	cyclin_D1	14,23	CDK4	24,28	cyclin D1	CDK4	595	1019	Gene	Gene	Validation|nmod|START_ENTITY Validation|dep|END_ENTITY	Validation of cyclin_D1 / CDK4 as an anticancer drug target in MCF-7 breast_cancer cells : Effect of regulated overexpression of cyclin_D1 and siRNA-mediated inhibition of endogenous cyclin_D1 and CDK4 expression .
16319987	0	cyclin_D1	180,189	CDK4	24,28	cyclin D1	CDK4	595	1019	Gene	Gene	endogenous|dep|START_ENTITY expression|amod|endogenous Effect|nmod|expression END_ENTITY|dep|Effect	Validation of cyclin_D1 / CDK4 as an anticancer drug target in MCF-7 breast_cancer cells : Effect of regulated overexpression of cyclin_D1 and siRNA-mediated inhibition of endogenous cyclin_D1 and CDK4 expression .
16400524	0	cyclin_D1	132,141	CDK4	142,146	cyclin D1	CDK4	524530(Tax:9913)	510618(Tax:9913)	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Recombinant human prothrombin kringle-2 induces bovine capillary endothelial cell cycle arrest at G0-G1 phase through inhibition of cyclin_D1 / CDK4 complex : modulation of reactive oxygen species generation and up-regulation of cyclin-dependent kinase inhibitors .
18353414	0	cyclin_D1	15,24	CDK4	25,29	cyclin D1	CDK4	58919(Tax:10116)	94201(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of cyclin_D1 / CDK4 and pRb mediated by PI3K/AKT pathway activation in Pb2 + - induced neuronal_death in cultured hippocampal neurons .
19035289	0	cyclin_D1	106,115	CDK4	116,120	cyclin D1	CDK4	595	1019	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Growth inhibition of human MDA-mB-231 breast_cancer cells by delta-tocotrienol is associated with loss of cyclin_D1 / CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma_tumor suppressor gene product .
20951943	0	cyclin_D1	8,17	CDK4	18,22	cyclin D1	CDK4	595	1019	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|kinase kinase|compound|END_ENTITY	Nuclear cyclin_D1 / CDK4 kinase regulates CUL4 expression and triggers neoplastic_growth via activation of the PRMT5 methyltransferase .
21077851	0	cyclin_D1	115,124	CDK4	125,129	cyclin D1	CDK4	12443(Tax:10090)	12567(Tax:10090)	Gene	Gene	down-regulation|nummod|START_ENTITY down-regulation|compound|END_ENTITY	The -3 epoxide of eicosapentaenoic_acid inhibits endothelial cell proliferation by p38 MAP kinase activation and cyclin_D1 / CDK4 down-regulation .
26337082	0	cyclin_D1	83,92	CDK4	93,97	cyclin D1	CDK4	595	1019	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Functional , chemical genomic , and super-enhancer screening identify sensitivity to cyclin_D1 / CDK4 pathway inhibition in Ewing_sarcoma .
9228064	0	cyclin_D1	45,54	CDK4	18,22	cyclin D1	CDK4	595	1019	Gene	Gene	binding|amod|START_ENTITY involved|nmod|binding involved|nsubj|Identification Identification|nmod|sequences sequences|nummod|END_ENTITY	Identification of CDK4 sequences involved in cyclin_D1 and p16 binding .
9244353	0	cyclin_D1	77,86	CDK4	22,26	cyclin D1	CDK4	595	1019	Gene	Gene	evidence|nmod|START_ENTITY requirement|dep|evidence requirement|nmod|END_ENTITY	Mutual requirement of CDK4 and Myc in malignant transformation : evidence for cyclin_D1 / CDK4 and p16INK4A as upstream regulators of Myc .
9244353	0	cyclin_D1	77,86	CDK4	87,91	cyclin D1	CDK4	595	1019	Gene	Gene	evidence|nmod|START_ENTITY requirement|dep|evidence requirement|dep|END_ENTITY	Mutual requirement of CDK4 and Myc in malignant transformation : evidence for cyclin_D1 / CDK4 and p16INK4A as upstream regulators of Myc .
9372967	0	cyclin_D1	20,29	CDK4	91,95	cyclin D1	CDK4	595	1019	Gene	Gene	mutant|amod|START_ENTITY prevents|nsubj|mutant prevents|dobj|import import|nmod|cyclin-dependent_kinase_4 cyclin-dependent_kinase_4|appos|END_ENTITY	A dominant-negative cyclin_D1 mutant prevents nuclear import of cyclin-dependent_kinase_4 -LRB- CDK4 -RRB- and its phosphorylation by CDK-activating kinase .
15256475	0	cyclin_D1	239,248	COX-2	250,255	cyclin D1	COX-2	595	4513	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Cyclooxygenase _ -LRB- COX -RRB- -2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor -LRB- NF -RRB- - kappaB by suppressing activation of IkappaBalpha kinase in human non-small_cell_lung_carcinoma : correlation with suppression of cyclin_D1 , COX-2 , and matrix_metalloproteinase-9 .
23838680	0	cyclin_D1	61,70	CREB	14,18	cyclin D1	CREB	595	1385	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of CREB in primary pterygium and correlation with cyclin_D1 , ki-67 , MMP7 , p53 , p63 , Survivin and Vimentin .
11290522	0	cyclin_D1	31,40	Cdc42	0,5	cyclin D1	Cdc42	524530(Tax:9913)	532712(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cdc42 , but not RhoA , regulates cyclin_D1 expression in bovine tracheal myocytes .
23627734	0	cyclin_D1	51,60	Cdk2	61,65	cyclin D1	Cdk2	595	1017	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	Assembly , activation , and substrate specificity of cyclin_D1 / Cdk2 complexes .
11481417	0	cyclin_D1	22,31	Cdk4	32,36	cyclin D1	Cdk4	595	1019	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Downregulation of the cyclin_D1 / Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon_cancer cell lines .
14522882	0	cyclin_D1	20,29	Cdk4	30,34	cyclin D1	Cdk4	58919(Tax:10116)	94201(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Deregulation of the cyclin_D1 / Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo -LSB- 4,5-b -RSB- pyridine .
14710852	0	cyclin_D1	19,28	Cdk4	39,43	cyclin D1	Cdk4	595	1019	Gene	Gene	Over-expression|nmod|START_ENTITY regulates|nsubj|Over-expression regulates|dobj|synthesis synthesis|amod|END_ENTITY	Over-expression of cyclin_D1 regulates Cdk4 protein synthesis .
14754892	0	cyclin_D1	14,23	Cdk4	24,28	cyclin D1	Cdk4	595	1019	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|parataxis|kinase kinase|nsubj|complexes complexes|amod|END_ENTITY	Regulation of cyclin_D1 / Cdk4 complexes by calcium/calmodulin-dependent protein kinase I .
16582602	0	cyclin_D1	10,19	Cdk4	20,24	cyclin D1	Cdk4	595	36854(Tax:7227)	Gene	Gene	START_ENTITY|parataxis|induce induce|nsubj|complexes complexes|amod|END_ENTITY	Mammalian cyclin_D1 / Cdk4 complexes induce cell growth in Drosophila .
8988060	0	cyclin_D1	29,38	Cdk4	70,74	cyclin D1	Cdk4	12443(Tax:10090)	12567(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Concurrent overexpression of cyclin_D1 and cyclin-dependent_kinase_4 -LRB- Cdk4 -RRB- in intestinal adenomas from multiple_intestinal_neoplasia -LRB- Min -RRB- mice and human familial_adenomatous_polyposis patients .
9099745	0	cyclin_D1	103,112	Cdk4	31,35	cyclin D1	Cdk4	595	1019	Gene	Gene	expression|amod|START_ENTITY accompanied|nmod|expression accompanied|nsubjpass|activation activation|nmod|END_ENTITY	Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin_D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2 .
11123420	0	cyclin_D1	24,33	Cip1	52,56	cyclin D1	Cip1	58919(Tax:10116)	114851(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of cyclin_D1 , cyclin_E and p21 -LRB- Cip1 -RRB- associated with decreased expression of p27 -LRB- Kip1 -RRB- in chemically induced rat mammary carcinogenesis .
11751903	0	cyclin_D1	19,28	Cip1	4,8	cyclin D1	Cip1	595	1026	Gene	Gene	accumulation|amod|START_ENTITY Promotes|dobj|accumulation Promotes|nsubj|p21 p21|appos|END_ENTITY	p21 -LRB- Cip1 -RRB- Promotes cyclin_D1 nuclear accumulation via direct inhibition of nuclear export .
7774959	0	cyclin_D1	34,43	Cyl-1	50,55	cyclin D1	Cyl-1	12443(Tax:10090)	12443(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the mouse cyclin_D1 gene -LRB- Cyl-1 -RRB- .
25322986	0	cyclin_D1	15,24	DACH1	0,5	cyclin D1	DACH1	595	1602	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	DACH1 inhibits cyclin_D1 expression , cellular proliferation and tumor growth of renal_cancer cells .
21506129	0	cyclin_D1	70,79	DEC1	44,48	cyclin D1	DEC1	595	50514	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Basic helix-loop-helix transcription factor DEC1 negatively regulates cyclin_D1 .
19567080	0	cyclin_D1	60,69	DNA_methyltransferase_3b	14,38	cyclin D1	DNA methyltransferase 3b	595	1789	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene END_ENTITY|nmod|expression	-LSB- Influence of DNA_methyltransferase_3b on the expression of cyclin_D1 gene and methylation of its promoters in human hepatocellular_carcinoma cells -RSB- .
25702703	0	cyclin_D1	82,91	Dicer	0,5	cyclin D1	Dicer	595	23405	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|levels levels|amod|END_ENTITY	Dicer regulated let-7 expression levels in p53-induced cancer repression requires cyclin_D1 .
10567390	0	cyclin_D1	18,27	E1A-associated_protein_p300	40,67	cyclin D1	E1A-associated protein p300	595	2033	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Activation of the cyclin_D1 gene by the E1A-associated_protein_p300 through AP-1 inhibits cellular apoptosis .
12532908	0	cyclin_D1	189,198	ER_alpha	231,239	cyclin D1	ER alpha	595	2099	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- Invasive_ductal_carcinoma of the breast : study of the number of copies of the CCND1 gene and chromosome 11 using fluorescence in situ hybridization -LRB- FISH -RRB- in comparison with expression of cyclin_D1 protein and estrogen_receptors -LRB- ER_alpha -RRB- with immunohistochemical detection -RSB- .
16267018	0	cyclin_D1	19,28	Egr-1	82,87	cyclin D1	Egr-1	595	1958	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Bombesin regulates cyclin_D1 expression through the early_growth_response_protein Egr-1 in prostate_cancer cells .
23619396	0	cyclin_D1	24,33	Endothelin-1	0,12	cyclin D1	Endothelin-1	58919(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates cyclin_D1 expression in rat cultured astrocytes via activation of Sp1 .
9568675	0	cyclin_D1	32,41	Epidermal_growth_factor	0,23	cyclin D1	Epidermal growth factor	595	1950	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Epidermal_growth_factor induces cyclin_D1 in a human prostate_cancer cell line .
24039221	0	cyclin_D1	39,48	Epidermal_growth_factor_receptor	0,32	cyclin D1	Epidermal growth factor receptor	595	1956	Gene	Gene	p16|nummod|START_ENTITY p16|compound|END_ENTITY	Epidermal_growth_factor_receptor , p16 , cyclin_D1 , and p53 staining patterns for inverted_papilloma .
7673150	0	cyclin_D1	68,77	Eukaryotic_translation_initiation_factor_4E	0,43	cyclin D1	Eukaryotic translation initiation factor 4E	12443(Tax:10090)	13684(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Eukaryotic_translation_initiation_factor_4E regulates expression of cyclin_D1 at transcriptional and post-transcriptional levels .
18378678	0	cyclin_D1	36,45	FHL2	21,25	cyclin D1	FHL2	12443(Tax:10090)	14200(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The LIM-only protein FHL2 regulates cyclin_D1 expression and cell proliferation .
19018287	0	cyclin_D1	70,79	FHL2	21,25	cyclin D1	FHL2	12443(Tax:10090)	14200(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY mediates|nmod|pathways mediates|nsubj|END_ENTITY	The LIM-only protein FHL2 mediates ras-induced transformation through cyclin_D1 and p53 pathways .
23525507	0	cyclin_D1	103,112	Folliculin	0,10	cyclin D1	Folliculin	595	201163	Gene	Gene	mRNA|amod|START_ENTITY region|nmod|mRNA elements|nmod|region regulates|nmod|elements regulates|nsubj|END_ENTITY	Folliculin regulates cyclin_D1 expression through cis-acting elements in the 3 ' untranslated region of cyclin_D1 mRNA .
23525507	0	cyclin_D1	21,30	Folliculin	0,10	cyclin D1	Folliculin	595	201163	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Folliculin regulates cyclin_D1 expression through cis-acting elements in the 3 ' untranslated region of cyclin_D1 mRNA .
17046823	0	cyclin_D1	100,109	GSK-3beta	15,24	cyclin D1	GSK-3beta	595	2932	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin_D1 in HeLa cells .
17560576	0	cyclin_D1	127,136	GSK-3beta	0,9	cyclin D1	GSK-3beta	12443(Tax:10090)	56637(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY mediates|nmod|localization mediates|amod|END_ENTITY	GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin_D2 nuclear localization and cell proliferation in cyclin_D1 - / - mouse uterine epithelium .
18023328	0	cyclin_D1	20,29	GSK-3beta	0,9	cyclin D1	GSK-3beta	595	2932	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GSK-3beta regulates cyclin_D1 expression : a new target for chemotherapy .
18769147	0	cyclin_D1	95,104	GSK-3beta	0,9	cyclin D1	GSK-3beta	595	2932	Gene	Gene	stability|amod|START_ENTITY enhance|dobj|stability activation|acl|enhance inhibition|dep|activation inhibition|amod|END_ENTITY	GSK-3beta inhibition : at the crossroad between Akt and mTOR constitutive activation to enhance cyclin_D1 protein stability in mantle_cell_lymphoma .
24134204	0	cyclin_D1	101,110	GSK3b	78,83	cyclin D1	GSK3b	595	2932	Gene	Gene	phosphorylate|dobj|START_ENTITY END_ENTITY|acl|phosphorylate	A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3b to phosphorylate cyclin_D1 at Thr -LRB- 286 -RRB- , not Thr -LRB- 288 -RRB- .
24218147	0	cyclin_D1	64,73	GSK3b	78,83	cyclin D1	GSK3b	58919(Tax:10116)	84027(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Perinatal exposure to BDE-99 causes decreased protein levels of cyclin_D1 via GSK3b activation and increased ROS production in rat pup livers .
18757415	0	cyclin_D1	81,90	HEXIM1	0,6	cyclin D1	HEXIM1	595	10614	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HEXIM1 regulates 17beta-estradiol/estrogen _ receptor-alpha-mediated expression of cyclin_D1 in mammary cells via modulation of P-TEFb .
15033176	0	cyclin_D1	37,46	IGF-I	0,5	cyclin D1	IGF-I	595	3479	Gene	Gene	association|amod|START_ENTITY enhance|dobj|association enhance|nsubj|END_ENTITY	IGF-I and FGF-2 coordinately enhance cyclin_D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells .
15580291	0	cyclin_D1	14,23	IGF-I	48,53	cyclin D1	IGF-I	595	3479	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression END_ENTITY|nsubj|Regulation	Regulation of cyclin_D1 expression by autocrine IGF-I in human BON_neuroendocrine_tumour cells .
17508424	0	cyclin_D1	25,34	IGF-I	74,79	cyclin D1	IGF-I	595	3479	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Synergistic induction of cyclin_D1 in oligodendrocyte progenitor cells by IGF-I and FGF-2 requires differential stimulation of multiple signaling pathways .
11102889	0	cyclin_D1	113,122	INK4A	93,98	cyclin D1	INK4A	595	1029	Gene	Gene	p16|amod|START_ENTITY p16|appos|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11751403	0	cyclin_D1	14,23	INK4A	32,37	cyclin D1	INK4A	12443(Tax:10090)	12578(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of cyclin_D1 and p16 -LRB- INK4A -RRB- is critical for growth arrest during mammary involution .
18413773	0	cyclin_D1	42,51	Id1	29,32	cyclin D1	Id1	595	3397	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	The helix-loop-helix protein Id1 requires cyclin_D1 to promote the proliferation of mammary epithelial cell acini .
21132436	0	cyclin_D1	87,96	KLF4	12,16	cyclin D1	KLF4	12443(Tax:10090)	16600(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of KLF4 in UVB-induced murine skin_tumor development and its correlation with cyclin_D1 , p53 , and p21 -LRB- Waf1/Cip1 -RRB- in epithelial_tumors of the human skin .
24499623	0	cyclin_D1	42,51	LMP1	27,31	cyclin D1	LMP1	595	9260	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Epstein-Barr_Virus encoded LMP1 regulates cyclin_D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells .
17639064	0	cyclin_D1	96,105	Leptin	0,6	cyclin D1	Leptin	595	3952	Gene	Gene	cells|nmod|START_ENTITY induces|nmod|cells induces|nsubj|END_ENTITY	Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin_D1 and down-regulating Bax via a Janus_kinase_2-linked pathway .
21472344	0	cyclin_D1	31,40	Leptin	0,6	cyclin D1	Leptin	595	3952	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Leptin and zeranol up-regulate cyclin_D1 expression in primary cultured normal human breast pre-adipocytes .
22692856	0	cyclin_D1	17,26	Leptin	0,6	cyclin D1	Leptin	12443(Tax:10090)	16846(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Leptin regulates cyclin_D1 in luminal epithelial cells of mouse MMTV-Wnt-1 mammary_tumors .
23300886	0	cyclin_D1	15,24	Leptin	0,6	cyclin D1	Leptin	595	3952	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leptin induces cyclin_D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT , PI3K/Akt and MEK/ERK pathways .
23354006	0	cyclin_D1	82,91	Leptin	0,6	cyclin D1	Leptin	595	3952	Gene	Gene	expression|amod|START_ENTITY increasing|dobj|expression stimulates|advcl|increasing stimulates|nsubj|END_ENTITY	Leptin stimulates ovarian_cancer cell growth and inhibits apoptosis by increasing cyclin_D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways .
10329038	0	cyclin_D1	86,95	MDM2	64,68	cyclin D1	MDM2	595	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	cyclin_D1	72,81	MDM2	93,97	cyclin D1	MDM2	595	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
24870800	0	cyclin_D1	73,82	MDM2	24,28	cyclin D1	MDM2	595	4193	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression mediates|xcomp|modulate mediates|nsubj|SNP SNP|nmod|promoter promoter|compound|END_ENTITY	A functional SNP in the MDM2 promoter mediates E2F1 affinity to modulate cyclin_D1 expression in tumor cell proliferation .
24979278	0	cyclin_D1	15,24	MUC1	0,4	cyclin D1	MUC1	595	4582	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MUC1 regulates cyclin_D1 gene expression through p120_catenin and b-catenin .
24995320	0	cyclin_D1	16,25	MiR-15b	0,7	cyclin D1	MiR-15b	595	406949	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	MiR-15b targets cyclin_D1 to regulate proliferation and apoptosis in glioma cells .
26631043	0	cyclin_D1	88,97	MiR-195	0,7	cyclin D1	MiR-195	595	406971	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-195 inhibits the proliferation of human cervical_cancer cells by directly targeting cyclin_D1 .
23383003	0	cyclin_D1	84,93	MicroRNA-195	0,12	cyclin D1	MicroRNA-195	595	406971	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-195 inhibits the proliferation of human glioma cells by directly targeting cyclin_D1 and cyclin_E1 .
20133739	0	cyclin_D1	64,73	MicroRNA-19a	0,12	cyclin D1	MicroRNA-19a	595	406979	Gene	Gene	expression|amod|START_ENTITY mediates|nmod|expression mediates|nsubj|END_ENTITY	MicroRNA-19a mediates the suppressive effect of laminar flow on cyclin_D1 expression in human umbilical vein endothelial cells .
20683643	0	cyclin_D1	24,33	MicroRNA-200b	0,13	cyclin D1	MicroRNA-200b	595	406984	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-200b regulates cyclin_D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells .
24936138	0	cyclin_D1	82,91	MicroRNA-365	0,12	cyclin D1	MicroRNA-365	58919(Tax:10116)	100314252(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MicroRNA-365 inhibits vascular smooth muscle cell proliferation through targeting cyclin_D1 .
24936138	0	cyclin_D1	82,91	MicroRNA-365	0,12	cyclin D1	MicroRNA-365	58919(Tax:10116)	100314252(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MicroRNA-365 inhibits vascular smooth muscle cell proliferation through targeting cyclin_D1 .
24578347	0	cyclin_D1	29,38	Mir302a	68,75	cyclin D1	Mir302a	12443(Tax:10090)	723920(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	GCNF-dependent activation of cyclin_D1 expression via repression of Mir302a during ESC differentiation .
7526316	0	cyclin_D1	12,21	Myc	0,3	cyclin D1	Myc	58919(Tax:10116)	24577(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Myc induces cyclin_D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle .
17130121	0	cyclin_D1	18,27	Myostatin	0,9	cyclin D1	Myostatin	12443(Tax:10090)	17700(Tax:10090)	Gene	Gene	degradation|amod|START_ENTITY induces|dobj|degradation induces|nsubj|END_ENTITY	Myostatin induces cyclin_D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK -3 _ beta pathway and is antagonized by insulin-like_growth_factor_1 .
11486031	0	cyclin_D1	13,22	Notch	58,63	cyclin D1	Notch	595	25496(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Induction of cyclin_D1 transcription and CDK2 activity by Notch -LRB- ic -RRB- : implication for cell cycle disruption in transformation by Notch -LRB- ic -RRB- .
19091404	0	cyclin_D1	93,102	Notch-1	0,7	cyclin D1	Notch-1	595	4851	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin_D1 , CDK2 and p21 in T-ALL cell lines .
16987002	0	cyclin_D1	30,39	Nox1	66,70	cyclin D1	Nox1	12443(Tax:10090)	237038(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Redox-dependent expression of cyclin_D1 and cell proliferation by Nox1 in mouse lung epithelial cells .
21487939	0	cyclin_D1	82,91	OVCA1	0,5	cyclin D1	OVCA1	595	1801	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	OVCA1 inhibits the proliferation of epithelial ovarian_cancer cells by decreasing cyclin_D1 and increasing p16 .
10318892	0	cyclin_D1	22,31	P/CAF	0,5	cyclin D1	P/CAF	595	8850	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	P/CAF associates with cyclin_D1 and potentiates its activation of the estrogen_receptor .
9214595	0	cyclin_D1	100,109	P27KIP1	28,35	cyclin D1	P27KIP1	595	1027	Gene	Gene	over-express|dobj|START_ENTITY lines|acl:relcl|over-express expression|nmod|lines expression|nmod|protein protein|compound|END_ENTITY	Increased expression of the P27KIP1 protein in human esophageal_cancer cell lines that over-express cyclin_D1 .
18197291	0	cyclin_D1	28,37	PI-3K	0,5	cyclin D1	PI-3K	595	5293	Gene	Gene	expression|amod|START_ENTITY responsible|nsubj|expression END_ENTITY|appos|responsible	PI-3K / Akt pathway-dependent cyclin_D1 expression is responsible for arsenite-induced human keratinocyte transformation .
15610522	0	cyclin_D1	22,31	PPARgamma	77,86	cyclin D1	PPARgamma	12443(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Troglitazone inhibits cyclin_D1 expression and cell cycling independently of PPARgamma in normal mouse skin keratinocytes .
7919385	0	cyclin_D1	7,16	PRAD-1	0,6	cyclin D1	PRAD-1	595	595	Gene	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	PRAD-1 / cyclin_D1 gene overexpression in chronic lymphoproliferative_disorders : a highly specific marker of mantle_cell_lymphoma .
15580289	0	cyclin_D1	90,99	PRAD1	100,105	cyclin D1	PRAD1	595	595	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Parafibromin , product of the hyperparathyroidism-jaw_tumor_syndrome_gene_HRPT2 , regulates cyclin_D1 / PRAD1 expression .
15885880	0	cyclin_D1	54,63	Prolactin	0,9	cyclin D1	Prolactin	595	5617	Gene	Gene	promoter|amod|START_ENTITY signals|nmod|promoter signals|nsubj|END_ENTITY	Prolactin signals via Stat5 and Oct-1 to the proximal cyclin_D1 promoter .
22658484	0	cyclin_D1	59,68	Prolactin	0,9	cyclin D1	Prolactin	12443(Tax:10090)	19109(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Prolactin promotes mammary pathogenesis independently from cyclin_D1 .
16166625	0	cyclin_D1	32,41	SMAR1	17,22	cyclin D1	SMAR1	12443(Tax:10090)	53325(Tax:10090)	Gene	Gene	repression|amod|START_ENTITY mediates|dobj|repression mediates|nsubj|END_ENTITY	Tumor suppressor SMAR1 mediates cyclin_D1 repression by recruitment of the SIN3/histone deacetylase 1 complex .
17989364	0	cyclin_D1	63,72	SMOC-2	25,31	cyclin D1	SMOC-2	12443(Tax:10090)	64074(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin_D1 expression and DNA synthesis via integrin-linked_kinase .
17412698	0	cyclin_D1	16,25	SOX6	0,4	cyclin D1	SOX6	12443(Tax:10090)	20679(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	SOX6 suppresses cyclin_D1 promoter activity by interacting with beta-catenin and histone_deacetylase_1 , and its down-regulation induces pancreatic beta-cell proliferation .
22249313	0	cyclin_D1	18,27	SSeCKS	0,6	cyclin D1	SSeCKS	12443(Tax:10090)	83397(Tax:10090)	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	SSeCKS sequesters cyclin_D1 in glomerular parietal epithelial cells and influences proliferative_injury in the glomerulus .
10064602	0	cyclin_D1	34,43	STAT5	56,61	cyclin D1	STAT5	595	6776	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Transcriptional regulation of the cyclin_D1 promoter by STAT5 : its involvement in cytokine-dependent growth of hematopoietic cells .
20372799	0	cyclin_D1	15,24	STAT5b	50,56	cyclin D1	STAT5b	595	6777	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Hemin inhibits cyclin_D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast_cancer cells .
20564361	0	cyclin_D1	81,90	Slug	0,4	cyclin D1	Slug	595	6591	Gene	Gene	expression|amod|START_ENTITY downregulation|nmod|expression cells|nmod|downregulation proliferation|nmod|cells inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	Slug inhibits proliferation of human prostate_cancer cells via downregulation of cyclin_D1 expression .
22711989	0	cyclin_D1	40,49	TAF1	100,104	cyclin D1	TAF1	595	6872	Gene	Gene	regulation|nmod|START_ENTITY transcription|nsubj|regulation transcription|nmod|END_ENTITY	Phosphorylation-dependent regulation of cyclin_D1 and cyclin_A gene transcription by TFIID subunits TAF1 and TAF7 .
12811822	0	cyclin_D1	60,69	TGF-beta	85,93	cyclin D1	TGF-beta	58919(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Eicosapentaenoic_acid inhibits PDGF-induced mitogenesis and cyclin_D1 expression via TGF-beta in mesangial cells .
10471535	0	cyclin_D1	24,33	TGF-beta-1	0,10	cyclin D1	TGF-beta-1	595	7040	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	TGF-beta-1 up-regulates cyclin_D1 expression in COLO-357 cells , whereas suppression of cyclin_D1 levels is associated with down-regulation of the type I TGF-beta receptor .
10329038	0	cyclin_D1	86,95	TP53	58,62	cyclin D1	TP53	595	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	cyclin_D1	72,81	TP53	0,4	cyclin D1	TP53	595	7157	Gene	Gene	proteins|nummod|START_ENTITY cycle-associated|xcomp|proteins cell|acl|cycle-associated alterations|nmod|cell alterations|nsubj|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
7824270	0	cyclin_D1	43,52	Transforming_growth_factor-beta_1	0,33	cyclin D1	Transforming growth factor-beta 1	58919(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits cyclin_D1 expression in intestinal epithelial cells .
21306487	0	cyclin_D1	34,43	Translokin	0,10	cyclin D1	Translokin	595	9702	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Translokin -LRB- Cep57 -RRB- interacts with cyclin_D1 and prevents its nuclear accumulation in quiescent fibroblasts .
23936312	0	cyclin_D1	95,104	WT1	0,3	cyclin D1	WT1	12443(Tax:10090)	22431(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	WT1 promotes cell proliferation in non-small cell lung_cancer cell lines through up-regulating cyclin_D1 and p-pRb in vitro and in vivo .
12612606	0	cyclin_D1	22,31	Wnt1	0,4	cyclin D1	Wnt1	595	7471	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Wnt1 and Wnt5a induce cyclin_D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells .
19056685	0	cyclin_D1	26,35	Zona_occludens-2	0,16	cyclin D1	Zona occludens-2	595	9414	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Zona_occludens-2 inhibits cyclin_D1 expression and cell proliferation and exhibits changes in localization along the cell cycle .
16964287	0	cyclin_D1	136,145	activator_protein-1	90,109	cyclin D1	activator protein-1	595	3725	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Involvement of protein phosphatase_2A nuclear accumulation and subsequent inactivation of activator_protein-1 in leptomycin_B-inhibited cyclin_D1 expression .
12941814	0	cyclin_D1	15,24	androgen_receptor	29,46	cyclin D1	androgen receptor	595	367	Gene	Gene	Specificity|nmod|START_ENTITY Specificity|nmod|regulation regulation|compound|END_ENTITY	Specificity of cyclin_D1 for androgen_receptor regulation .
20421209	0	cyclin_D1	14,23	androgen_receptor	38,55	cyclin D1	androgen receptor	595	367	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of cyclin_D1 expression by androgen_receptor in breast_cancer cells -- identification of a novel androgen response element .
26135564	0	cyclin_D1	83,92	b-catenin	38,47	cyclin D1	b-catenin	58919(Tax:10116)	1499	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Glucagon phosphorylates serine 552 of b-catenin leading to increased expression of cyclin_D1 and c-Myc in the isolated rat liver .
9070488	0	cyclin_D1	56,65	bcl-1	50,55	cyclin D1	bcl-1	595	595	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Molecular and immunohistochemical analysis of the bcl-1 / cyclin_D1 gene in laryngeal_squamous_cell_carcinomas : correlation of protein expression with lymph node metastases and advanced clinical stage .
17315172	0	cyclin_D1	89,98	beta-Catenin	0,12	cyclin D1	beta-Catenin	595	1499	Gene	Gene	overexpression|amod|START_ENTITY role|nmod|overexpression accumulation|dep|role accumulation|amod|END_ENTITY	beta-Catenin nuclear accumulation in head and neck mucoepidermoid_carcinoma : its role in cyclin_D1 overexpression and tumor progression .
11309340	0	cyclin_D1	96,105	beta-catenin	40,52	cyclin D1	beta-catenin	595	1499	Gene	Gene	overexpression|nmod|START_ENTITY associated|nmod|overexpression associated|nsubjpass|deletions deletions|nmod|gene gene|amod|END_ENTITY	Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin_D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma .
11592102	0	cyclin_D1	48,57	beta-catenin	0,12	cyclin D1	beta-catenin	595	1499	Gene	Gene	overexpression|amod|START_ENTITY correlates|nmod|overexpression correlates|nsubj|expression expression|amod|END_ENTITY	beta-catenin nuclear expression correlates with cyclin_D1 overexpression in sporadic_desmoid_tumours .
11836555	0	cyclin_D1	24,33	beta-catenin	89,101	cyclin D1	beta-catenin	595	1499	Gene	Gene	Immunohistochemistry|nmod|START_ENTITY Immunohistochemistry|nmod|gene gene|amod|END_ENTITY	Immunohistochemistry of cyclin_D1 and beta-catenin , and mutational analysis of exon 3 of beta-catenin gene in parathyroid_adenomas .
12878043	0	cyclin_D1	46,55	beta-catenin	24,36	cyclin D1	beta-catenin	12443(Tax:10090)	12387(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|targets targets|amod|END_ENTITY	Expression of potential beta-catenin targets , cyclin_D1 , c-Jun , c-Myc , E-cadherin , and EGFR in chemically_induced_hepatocellular_neoplasms from B6C3F1 mice .
14666673	0	cyclin_D1	74,83	beta-catenin	24,36	cyclin D1	beta-catenin	595	1499	Gene	Gene	expression|nmod|START_ENTITY correlated|nmod|expression correlated|nsubjpass|localization localization|nmod|END_ENTITY	Nuclear localization of beta-catenin is correlated with the expression of cyclin_D1 in endometrial_carcinomas .
15017589	0	cyclin_D1	83,92	beta-catenin	62,74	cyclin D1	beta-catenin	595	1499	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical evaluation of adenomatous_polyposis_coli , beta-catenin , c-Myc , cyclin_D1 , p53 , and retinoblastoma protein expression in syndromic and sporadic fundic_gland_polyps .
15116100	0	cyclin_D1	31,40	beta-catenin	64,76	cyclin D1	beta-catenin	595	1499	Gene	Gene	transcription|amod|START_ENTITY activation|nmod|transcription involves|nsubj|activation involves|dobj|pathways pathways|amod|END_ENTITY	Gastrin-mediated activation of cyclin_D1 transcription involves beta-catenin and CREB pathways in gastric_cancer cells .
15791567	0	cyclin_D1	102,111	beta-catenin	9,21	cyclin D1	beta-catenin	595	1499	Gene	Gene	expression|nmod|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|amod|END_ENTITY	Abnormal beta-catenin expression in oral_cancer with no gene mutation : correlation with expression of cyclin_D1 and epidermal_growth_factor_receptor , Ki-67 labeling index , and clinicopathological features .
15946752	0	cyclin_D1	41,50	beta-catenin	0,12	cyclin D1	beta-catenin	58919(Tax:10116)	84353(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY signaling|nmod|promoter signaling|amod|END_ENTITY	beta-catenin signaling and regulation of cyclin_D1 promoter in NRK-49F cells transformed by down-regulation of the tumor suppressor lysyl_oxidase .
16690606	0	cyclin_D1	43,52	beta-catenin	86,98	cyclin D1	beta-catenin	12443(Tax:10090)	12387(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nmod|activation activation|nmod|END_ENTITY	Transforming growth factor-beta stimulates cyclin_D1 expression through activation of beta-catenin signaling in chondrocytes .
16733209	0	cyclin_D1	37,46	beta-catenin	8,20	cyclin D1	beta-catenin	595	1499	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|END_ENTITY	Nuclear beta-catenin correlates with cyclin_D1 expression in spindle and pleomorphic_sarcomas but not in synovial_sarcoma .
17412698	0	cyclin_D1	16,25	beta-catenin	64,76	cyclin D1	beta-catenin	12443(Tax:10090)	12387(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY suppresses|dobj|activity suppresses|advcl|interacting interacting|nmod|END_ENTITY	SOX6 suppresses cyclin_D1 promoter activity by interacting with beta-catenin and histone_deacetylase_1 , and its down-regulation induces pancreatic beta-cell proliferation .
20235220	0	cyclin_D1	70,79	beta-catenin	0,12	cyclin D1	beta-catenin	595	1499	Gene	Gene	expression|amod|START_ENTITY promote|dobj|expression mediates|xcomp|promote mediates|nsubj|END_ENTITY	beta-catenin mediates insulin-like growth factor-I actions to promote cyclin_D1 mRNA expression , cell proliferation and survival in oligodendroglial cultures .
11798599	0	cyclin_D1	27,36	bombesin	15,23	cyclin D1	bombesin	595	2922	Gene	Gene	-LSB-|nmod|START_ENTITY -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The effect of bombesin on cyclin_D1 / CDK4 of immortalized human gastric epithelial cell line -RSB- .
15467760	0	cyclin_D1	115,124	c-Jun	140,145	cyclin D1	c-Jun	595	3725	Gene	Gene	START_ENTITY|nmod|binding binding|nmod|END_ENTITY	Estrogen-induced proliferation of normal endometrial glandular cells is initiated by transcriptional activation of cyclin_D1 via binding of c-Jun to an AP-1 sequence .
12668975	0	cyclin_D1	31,40	c-Jun-N-terminal_kinase	0,23	cyclin D1	c-Jun-N-terminal kinase	58919(Tax:10116)	116554(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY drives|dobj|expression drives|nsubj|END_ENTITY	c-Jun-N-terminal_kinase drives cyclin_D1 expression and proliferation during liver_regeneration .
15687240	0	cyclin_D1	45,54	c-Myb	36,41	cyclin D1	c-Myb	595	4602	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive and negative regulation of c-Myb by cyclin_D1 , cyclin-dependent kinases , and p27_Kip1 .
15017589	0	cyclin_D1	83,92	c-Myc	76,81	cyclin D1	c-Myc	595	4609	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Immunohistochemical evaluation of adenomatous_polyposis_coli , beta-catenin , c-Myc , cyclin_D1 , p53 , and retinoblastoma protein expression in syndromic and sporadic fundic_gland_polyps .
9001421	0	cyclin_D1	152,161	c-myc	31,36	cyclin D1	c-myc	595	4609	Gene	Gene	exerted|nmod|START_ENTITY activity|acl|exerted cells|dep|activity transformed|dobj|cells BCR-ABL|acl|transformed controls|nmod|BCR-ABL controls|dobj|transcription transcription|amod|END_ENTITY	Cyclic_AMP negatively controls c-myc transcription and G1 cell cycle progression in p210 BCR-ABL transformed cells : inhibitory activity exerted through cyclin_D1 and cdk4 .
18957421	0	cyclin_D1	14,23	cAMP-responsive_element-binding_protein	54,93	cyclin D1	cAMP-responsive element-binding protein	595	1385	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of cyclin_D1 and Wnt10b gene expression by cAMP-responsive_element-binding_protein during early adipogenesis involves differential promoter methylation .
10329038	0	cyclin_D1	86,95	cdk4	80,84	cyclin D1	cdk4	595	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
16024155	0	cyclin_D1	116,125	cdk4	126,130	cyclin D1	cdk4	58919(Tax:10116)	94201(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY progression|nmod|activation Induction|nmod|progression Induction|parataxis|END_ENTITY	Induction of urothelial proliferation in rats by aristolochic_acid through cell cycle progression via activation of cyclin_D1 / cdk4 and cyclin_E / cdk2 .
19143767	0	cyclin_D1	28,37	cdk4	38,42	cyclin D1	cdk4	595	1019	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Myc down-regulation affects cyclin_D1 / cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line .
9290582	0	cyclin_D1	20,29	cdk4	30,34	cyclin D1	cdk4	58919(Tax:10116)	94201(Tax:10116)	Gene	Gene	Immunoreactivity|nmod|START_ENTITY Immunoreactivity|parataxis|END_ENTITY	Immunoreactivity of cyclin_D1 / cdk4 in neurons and oligodendrocytes after focal cerebral_ischemia in rat .
19624419	0	cyclin_D1	41,50	cyclin_A	52,60	cyclin D1	cyclin A	595	890	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
17560576	0	cyclin_D1	127,136	cyclin_D2	70,79	cyclin D1	cyclin D2	12443(Tax:10090)	12444(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|amod|END_ENTITY	GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin_D2 nuclear localization and cell proliferation in cyclin_D1 - / - mouse uterine epithelium .
22214766	0	cyclin_D1	58,67	cyclin_D3	19,28	cyclin D1	cyclin D3	12443(Tax:10090)	12445(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Combined effect of cyclin_D3 expression and abrogation of cyclin_D1 prevent mouse skin_tumor development .
25225463	0	cyclin_D1	113,122	epidermal_growth_factor_receptor	14,46	cyclin D1	epidermal growth factor receptor	595	1956	Gene	Gene	epidermal|amod|START_ENTITY epidermal|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
10723135	0	cyclin_D1	94,103	eukaryotic_translation_initiation_factor_4E	41,84	cyclin D1	eukaryotic translation initiation factor 4E	58919(Tax:10116)	117045(Tax:10116)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Inhibition Inhibition|nmod|apoptosis apoptosis|nmod|END_ENTITY	Inhibition of Myc-dependent apoptosis by eukaryotic_translation_initiation_factor_4E requires cyclin_D1 .
16644723	0	cyclin_D1	38,47	glucocorticoid_receptor	4,27	cyclin D1	glucocorticoid receptor	595	2908	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	The glucocorticoid_receptor represses cyclin_D1 by targeting the Tcf-beta-catenin complex .
17989364	0	cyclin_D1	63,72	integrin-linked_kinase	106,128	cyclin D1	integrin-linked kinase	12443(Tax:10090)	16202(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin_D1 expression and DNA synthesis via integrin-linked_kinase .
18988190	0	cyclin_D1	62,71	leptin	14,20	cyclin D1	leptin	595	3952	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|Evidence Evidence|acl:relcl|END_ENTITY	Evidence that leptin through STAT and CREB signaling enhances cyclin_D1 expression and promotes human endometrial_cancer proliferation .
18216175	0	cyclin_D1	16,25	meis1	0,5	cyclin D1	meis1	30222(Tax:7955)	170446(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	meis1 regulates cyclin_D1 and c-myc expression , and controls the proliferation of the multipotent cells in the early developing zebrafish eye .
17149750	0	cyclin_D1	97,106	nuclear_factor-kappaB	75,96	cyclin D1	nuclear factor-kappaB	595	4790	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Id1 induces the proliferation of cochlear sensory epithelial cells via the nuclear_factor-kappaB / cyclin_D1 pathway in vitro .
24979278	0	cyclin_D1	15,24	p120_catenin	49,61	cyclin D1	p120 catenin	595	1500	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	MUC1 regulates cyclin_D1 gene expression through p120_catenin and b-catenin .
22860097	0	cyclin_D1	50,59	p14ARF	0,6	cyclin D1	p14ARF	595	1029	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	p14ARF post-transcriptional regulation of nuclear cyclin_D1 in MCF-7 breast_cancer cells : discrimination between a good and bad prognosis ?
12378511	0	cyclin_D1	46,55	p16	36,39	cyclin D1	p16	595	1029	Gene	Gene	p27|dep|START_ENTITY p27|dep|END_ENTITY	Expression of G1-S modulators -LRB- p53 , p16 , p27 , cyclin_D1 , Rb -RRB- and Smad4/Dpc4 in intrahepatic_cholangiocarcinoma .
17060721	0	cyclin_D1	29,38	p16	24,27	cyclin D1	p16	595	1029	Gene	Gene	esophageal_squamous_cell_carcinoma|nummod|START_ENTITY esophageal_squamous_cell_carcinoma|dep|END_ENTITY	-LSB- The expression of p53 , p16 , cyclin_D1 in esophageal_squamous_cell_carcinoma and esophageal_dysplasia -RSB- .
19624419	0	cyclin_D1	41,50	p16	72,75	cyclin D1	p16	595	1029	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
21799732	0	cyclin_D1	33,42	p16	0,3	cyclin D1	p16	595	1029	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p16 -LRB- INK4a -RRB- positively regulates cyclin_D1 and E2F1 through negative control of AUF1 .
25189115	0	cyclin_D1	127,136	p16	121,124	cyclin D1	p16	595	1029	Gene	Gene	CDK4|dep|START_ENTITY CDK4|amod|END_ENTITY	Duhuo Jisheng Decoction - containing serum promotes proliferation of interleukin __ -1 b - induced chondrocytes through the p16 - cyclin_D1 / CDK4 - Rb pathway .
10329038	0	cyclin_D1	86,95	p21	70,73	cyclin D1	p21	595	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	cyclin_D1	72,81	p21	67,70	cyclin D1	p21	595	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
10762631	0	cyclin_D1	23,32	p21	0,3	cyclin D1	p21	595	1026	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	p21 is associated with cyclin_D1 , p16INK4a and pRb expression in resectable non-small_cell_lung_cancer .
11102889	0	cyclin_D1	113,122	p21	101,104	cyclin D1	p21	595	1026	Gene	Gene	p16|amod|START_ENTITY p16|appos|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11494229	0	cyclin_D1	28,37	p21	87,90	cyclin D1	p21	595	1026	Gene	Gene	protein|amod|START_ENTITY localisation|nmod|protein associated|nsubjpass|localisation associated|nmod|expression expression|amod|END_ENTITY	Subcellular localisation of cyclin_D1 protein in colorectal_tumours is associated with p21 -LRB- WAF1/CIP1 -RRB- expression and correlates with patient survival .
11751903	0	cyclin_D1	19,28	p21	0,3	cyclin D1	p21	595	644914	Gene	Gene	accumulation|amod|START_ENTITY Promotes|dobj|accumulation Promotes|nsubj|END_ENTITY	p21 -LRB- Cip1 -RRB- Promotes cyclin_D1 nuclear accumulation via direct inhibition of nuclear export .
12018448	0	cyclin_D1	10,19	p21	0,3	cyclin D1	p21	595	1026	Gene	Gene	p27|nummod|START_ENTITY p27|nummod|END_ENTITY	p21 , p27 , cyclin_D1 , and p53 in rectal_cancer : immunohistology with prognostic significance ?
17942917	0	cyclin_D1	59,68	p21	111,114	cyclin D1	p21	595	644914	Gene	Gene	Nutlin-3|nmod|START_ENTITY response|nmod|Nutlin-3 suppression|nmod|response transformed|nsubj|suppression transformed|ccomp|occurs occurs|nmod|END_ENTITY	p53-mediated growth suppression in response to Nutlin-3 in cyclin_D1 transformed cells occurs independently of p21 .
18343280	0	cyclin_D1	48,57	p21	27,30	cyclin D1	p21	595	644914	Gene	Gene	expression|amod|START_ENTITY altering|dobj|expression downregulates|advcl|altering downregulates|dobj|END_ENTITY	Temsirolimus downregulates p21 without altering cyclin_D1 expression and induces autophagy and synergizes with vorinostat in mantle_cell_lymphoma .
19624419	0	cyclin_D1	41,50	p21	67,70	cyclin D1	p21	595	1026	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
24037529	0	cyclin_D1	144,153	p21	117,120	cyclin D1	p21	12443(Tax:10090)	12575(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY progression|nmod|inhibition limits|dobj|progression limits|nsubj|END_ENTITY	PTEN ablation in Ras -LRB- Ha -RRB- / Fos skin_carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin_D1 / E2 inhibition .
24037529	0	cyclin_D1	144,153	p21	71,74	cyclin D1	p21	12443(Tax:10090)	12575(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY progression|nmod|inhibition limits|dobj|progression delay|advcl|limits invokes|xcomp|delay invokes|dobj|END_ENTITY	PTEN ablation in Ras -LRB- Ha -RRB- / Fos skin_carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin_D1 / E2 inhibition .
7671232	0	cyclin_D1	38,47	p21	13,16	cyclin D1	p21	595	1026	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|p53 p53|nmod|END_ENTITY	p53 , through p21 -LRB- WAF1/CIP1 -RRB- , induces cyclin_D1 synthesis .
9191053	0	cyclin_D1	32,41	p21	98,101	cyclin D1	p21	595	644914	Gene	Gene	expression|nmod|START_ENTITY induces|nsubj|expression induces|dobj|activation activation|nmod|gene gene|amod|END_ENTITY	Regulated ectopic expression of cyclin_D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression .
16170570	0	cyclin_D1	162,171	p21CIP1	122,129	cyclin D1	p21CIP1	595	1026	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	p53-independent G1 cell cycle arrest of human colon_carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin_D1 .
19935879	0	cyclin_D1	60,69	p21Cip1	103,110	cyclin D1	p21Cip1	595	1026	Gene	Gene	concomitant|amod|START_ENTITY concomitant|nmod|elevation elevation|nmod|END_ENTITY	Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin_D1 concomitant with an elevation in p21Cip1 in human cervical_carcinoma HeLa cells .
18616527	0	cyclin_D1	33,42	p21cip1	118,125	cyclin D1	p21cip1	595	1026	Gene	Gene	mediates|amod|START_ENTITY mediates|nmod|factor factor|amod|END_ENTITY	Reactive oxygen species-mediated cyclin_D1 degradation mediates tumor_growth_retardation in hypoxia , independently of p21cip1 and hypoxia-inducible factor .
10329038	0	cyclin_D1	86,95	p27	75,78	cyclin D1	p27	595	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
11115553	0	cyclin_D1	44,53	p27	23,26	cyclin D1	p27	595	10671	Gene	Gene	inhibit|dobj|START_ENTITY END_ENTITY|acl|inhibit	Insufficient effect of p27 -LRB- KIP1 -RRB- to inhibit cyclin_D1 in human esophageal_cancer in vitro .
11123420	0	cyclin_D1	24,33	p27	98,101	cyclin D1	p27	58919(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY associated|nsubj|expression associated|nmod|expression expression|nmod|Kip1 Kip1|amod|END_ENTITY	Increased expression of cyclin_D1 , cyclin_E and p21 -LRB- Cip1 -RRB- associated with decreased expression of p27 -LRB- Kip1 -RRB- in chemically induced rat mammary carcinogenesis .
19242098	0	cyclin_D1	106,115	p27	101,104	cyclin D1	p27	595	3429	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric_cancer cells by regulating p27 , cyclin_D1 expression and cytochrome_C release .
19624419	0	cyclin_D1	41,50	p27	62,65	cyclin D1	p27	595	3429	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
20843055	0	cyclin_D1	38,47	p27	56,59	cyclin D1	p27	595	3429	Gene	Gene	analysis|nmod|START_ENTITY reveals|nsubj|analysis reveals|dobj|END_ENTITY	Structural and functional analysis of cyclin_D1 reveals p27 and substrate inhibitor binding requirements .
21693435	0	cyclin_D1	53,62	p27	44,47	cyclin D1	p27	58919(Tax:10116)	83571(Tax:10116)	Gene	Gene	mislocalization|dep|START_ENTITY mislocalization|nmod|END_ENTITY	cAMP-dependent cytosolic mislocalization of p27 -LRB- kip -RRB- - cyclin_D1 during quinol-thioether-induced tuberous_sclerosis renal cell carcinoma .
11035575	0	cyclin_D1	71,80	p27KIP1	98,105	cyclin D1	p27KIP1	595	1027	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Multiparameter immunohistochemical analysis of the cell cycle proteins cyclin_D1 , Ki-67 , p21WAF1 , p27KIP1 , and p53 in mantle_cell_lymphoma .
15029207	0	cyclin_D1	43,52	p27KIP1	21,28	cyclin D1	p27KIP1	595	1027	Gene	Gene	lymphoproliferative_disorders|amod|START_ENTITY impact|nmod|lymphoproliferative_disorders impact|nmod|expression expression|amod|END_ENTITY	Prognostic impact of p27KIP1 expression in cyclin_D1 positive lymphoproliferative_disorders .
18180298	0	cyclin_D1	10,19	p27KIP1	44,51	cyclin D1	p27KIP1	595	1027	Gene	Gene	mRNA|amod|START_ENTITY modulates|nsubj|mRNA modulates|dobj|binding binding|amod|END_ENTITY	Alternate cyclin_D1 mRNA splicing modulates p27KIP1 binding and cell migration .
24178620	0	cyclin_D1	124,133	p27KIP1	134,141	cyclin D1	p27KIP1	595	1027	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Antitumoral activity of lenalidomide in in vitro and in vivo models of mantle_cell_lymphoma involves the destabilization of cyclin_D1 / p27KIP1 complexes .
11016654	0	cyclin_D1	75,84	p27Kip1	8,15	cyclin D1	p27Kip1	595	1027	Gene	Gene	complexes|amod|START_ENTITY _|nmod|complexes _|nsubj|Loss Loss|nmod|_ _|amod|END_ENTITY	Loss of p27Kip1 from cyclin E/cyclin-dependent _ kinase _ -LRB- CDK -RRB- _ 2 but not from cyclin_D1 / CDK4 complexes in cells transformed by polyamine biosynthetic enzymes .
12515730	0	cyclin_D1	36,45	p27Kip1	17,24	cyclin D1	p27Kip1	595	1027	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Sequestration of p27Kip1 protein by cyclin_D1 in typical and blastic variants of mantle_cell_lymphoma -LRB- MCL -RRB- : implications for pathogenesis .
15371458	0	cyclin_D1	119,128	p27Kip1	19,26	cyclin D1	p27Kip1	58919(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induced|nmod|expression cardiomyocytes|acl|induced proliferation|nmod|cardiomyocytes promotes|dobj|proliferation promotes|nsubj|Down-regulation Down-regulation|nmod|END_ENTITY	Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin_D1 and CDK4 .
8780883	0	cyclin_D1	24,33	p27kip1	83,90	cyclin D1	p27kip1	595	1027	Gene	Gene	expression|nmod|START_ENTITY induces|nsubj|expression induces|dobj|END_ENTITY	Increased expression of cyclin_D1 in a murine mammary epithelial cell line induces p27kip1 , inhibits growth , and enhances apoptosis .
10637437	0	cyclin_D1	68,77	p53	132,135	cyclin D1	p53	595	7157	Gene	Gene	transfer|amod|START_ENTITY differentiation|nmod|transfer suppression|nmod|differentiation involves|nsubj|suppression involves|dobj|induction induction|nmod|dismutases dismutases|compound|END_ENTITY	Tumor suppression without differentiation or apoptosis by antisense cyclin_D1 gene transfer in K1735 melanoma involves induction of p53 , p21WAF1 and superoxide dismutases .
10990069	0	cyclin_D1	14,23	p53	115,118	cyclin D1	p53	595	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|significance significance|nmod|END_ENTITY	Expression of cyclin_D1 , Ki-67 and PCNA in non-small_cell_lung_cancer : prognostic significance and comparison with p53 and bcl-2 .
11102889	0	cyclin_D1	113,122	p53	84,87	cyclin D1	p53	595	7157	Gene	Gene	p16|amod|START_ENTITY END_ENTITY|appos|p16	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11798189	0	cyclin_D1	51,60	p53	0,3	cyclin D1	p53	595	7157	Gene	Gene	expression|amod|START_ENTITY down-regulation|nmod|expression inhibits|dobj|down-regulation inhibits|nsubj|END_ENTITY	p53 inhibits adriamycin-induced down-regulation of cyclin_D1 expression in human cancer cells .
11838966	0	cyclin_D1	59,68	p53	80,83	cyclin D1	p53	595	7157	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	TSG101 expression in gynecological tumors : relationship to cyclin_D1 , cyclin E , p53 and p16 proteins .
12185899	0	cyclin_D1	42,51	p53	17,20	cyclin D1	p53	595	7157	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	-LSB- Inactivation of p53 and amplification of cyclin_D1 in squamous_cell_carcinomas of the head_and_neck -RSB- .
12378511	0	cyclin_D1	46,55	p53	31,34	cyclin D1	p53	595	7157	Gene	Gene	p27|dep|START_ENTITY p27|compound|END_ENTITY	Expression of G1-S modulators -LRB- p53 , p16 , p27 , cyclin_D1 , Rb -RRB- and Smad4/Dpc4 in intrahepatic_cholangiocarcinoma .
12771941	0	cyclin_D1	11,20	p53	117,120	cyclin D1	p53	12443(Tax:10090)	22060(Tax:10090)	Gene	Gene	overexpression|amod|START_ENTITY overexpression|acl:relcl|heterozygous heterozygous|nmod|END_ENTITY	HBX causes cyclin_D1 overexpression and development of breast_cancer in transgenic animals that are heterozygous for p53 .
12808109	0	cyclin_D1	14,23	p53	0,3	cyclin D1	p53	595	7157	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	p53 represses cyclin_D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone_deacetylase_1 .
15060836	0	cyclin_D1	34,43	p53	164,167	cyclin D1	p53	595	7157	Gene	Gene	E|amod|START_ENTITY expression|nmod|E expression|dep|correlation correlation|nmod|proteins proteins|dep|Rb Rb|dep|END_ENTITY	Immunohistochemical expression of cyclin_D1 , cyclin E , p21/waf1 and p27/kip1 in inflammatory_bowel_disease : correlation with other cell-cycle-related proteins -LRB- Rb , p53 , ki-67 and PCNA -RRB- and clinicopathological features .
15362377	0	cyclin_D1	143,152	p53	120,123	cyclin D1	p53	595	7157	Gene	Gene	p27Kip1|nummod|START_ENTITY END_ENTITY|appos|p27Kip1	Prognostic factors in survival of patients with stage Ta and T1 bladder urothelial_tumors : the role of G1-S modulators -LRB- p53 , p21Waf1 , p27Kip1 , cyclin_D1 , and cyclin_D3 -RRB- , proliferation index , and clinicopathologic parameters .
16752079	0	cyclin_D1	95,104	p53	155,158	cyclin D1	p53	595	7157	Gene	Gene	c-Myc|dep|START_ENTITY END_ENTITY|amod|c-Myc	Leptin-induced growth of human ZR-75-1 breast_cancer cells is associated with up-regulation of cyclin_D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1 .
17060721	0	cyclin_D1	29,38	p53	19,22	cyclin D1	p53	595	7157	Gene	Gene	esophageal_squamous_cell_carcinoma|nummod|START_ENTITY esophageal_squamous_cell_carcinoma|compound|END_ENTITY	-LSB- The expression of p53 , p16 , cyclin_D1 in esophageal_squamous_cell_carcinoma and esophageal_dysplasia -RSB- .
17935714	0	cyclin_D1	77,86	p53	14,17	cyclin D1	p53	595	7157	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|Abrogation Abrogation|nmod|END_ENTITY	Abrogation of p53 by its antisense in MCF-7 breast_carcinoma cells increases cyclin_D1 via activation of Akt and promotion of cell proliferation .
19800042	0	cyclin_D1	55,64	p53	22,25	cyclin D1	p53	595	7157	Gene	Gene	gene|amod|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	An inhibitory role of p53 via NF-kappaB element on the cyclin_D1 gene under heat_shock .
21320401	0	cyclin_D1	45,54	p53	80,83	cyclin D1	p53	12443(Tax:10090)	22060(Tax:10090)	Gene	Gene	oncoprotein|amod|START_ENTITY oncoprotein|nmod|END_ENTITY	-LSB- An experimental study on the association of cyclin_D1 oncoprotein with mutated p53 in progressive development of pulmonary_tumors -RSB- .
21590019	0	cyclin_D1	14,23	p53	43,46	cyclin D1	p53	595	7157	Gene	Gene	protein|amod|START_ENTITY related|nsubj|protein related|nmod|proteins proteins|compound|END_ENTITY	Overexpressed cyclin_D1 protein related to p53 and retinoblastoma proteins in transitional_cell_carcinoma_of_the_urinary_tract .
21786090	0	cyclin_D1	65,74	p53	0,3	cyclin D1	p53	595	7157	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	p53 and cyclooxygenase-2 expression are directly associated with cyclin_D1 expression in radical prostatectomy specimens of patients with hormone-na ve prostate_cancer .
22315488	0	cyclin_D1	14,23	p53	83,86	cyclin D1	p53	595	7157	Gene	Gene	isoforms|amod|START_ENTITY isoforms|appos|morphology morphology|dep|alterations alterations|compound|END_ENTITY	The impact of cyclin_D1 mRNA isoforms , morphology and p53 in mantle_cell_lymphoma : p53 alterations and blastoid morphology are strong predictors of a high proliferation index .
25225463	0	cyclin_D1	113,122	p53	48,51	cyclin D1	p53	595	7157	Gene	Gene	epidermal|amod|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
7671232	0	cyclin_D1	38,47	p53	0,3	cyclin D1	p53	595	7157	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	p53 , through p21 -LRB- WAF1/CIP1 -RRB- , induces cyclin_D1 synthesis .
7784093	0	cyclin_D1	45,54	p53	12,15	cyclin D1	p53	595	7157	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of p53 in coordinated regulation of cyclin_D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes .
8641982	0	cyclin_D1	31,40	p53	76,79	cyclin D1	p53	595	7157	Gene	Gene	gene|amod|START_ENTITY collaboration|nmod|gene collaboration|nmod|END_ENTITY	Oncogenic collaboration of the cyclin_D1 -LRB- PRAD1 , bcl-1 -RRB- gene with a mutated p53 and an activated ras oncogene in neoplastic_transformation .
9504605	0	cyclin_D1	41,50	p53	16,19	cyclin D1	p53	595	7157	Gene	Gene	correlate|amod|START_ENTITY Inactivation|nmod|correlate Inactivation|nmod|END_ENTITY	Inactivation of p53 and amplification of cyclin_D1 correlate with clinical outcome in head_and_neck_cancer .
9722210	0	cyclin_D1	33,42	p53	82,85	cyclin D1	p53	595	7157	Gene	Gene	downregulation|nmod|START_ENTITY Association|nmod|downregulation Association|nmod|mutation mutation|compound|END_ENTITY	Association of downregulation of cyclin_D1 and of overexpression of cyclin E with p53 mutation , high tumor grade and poor prognosis in hepatocellular_carcinoma .
9815783	0	cyclin_D1	27,36	p53	87,90	cyclin D1	p53	595	7157	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|abnormalities abnormalities|compound|END_ENTITY	Prognostic significance of cyclin_D1 and retinoblastoma expression in combination with p53 abnormalities in primary , resected non-small_cell_lung_cancers .
12594215	0	cyclin_D1	34,43	pRB	71,74	cyclin D1	pRB	595	5925	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	NF-kappa_B-dependent induction of cyclin_D1 by retinoblastoma protein -LRB- pRB -RRB- family proteins and tumor-derived pRB mutants .
15845746	0	cyclin_D1	89,98	pRB	101,104	cyclin D1	pRB	595	5925	Gene	Gene	GSK-3beta|dep|START_ENTITY >|dep|GSK-3beta >|amod|pathway pathway|advmod|END_ENTITY	Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase -- > AKT -- > GSK-3beta -- > cyclin_D1 -- > pRB pathway to block uterine epithelial cell proliferation .
15809880	0	cyclin_D1	20,29	pRb	65,68	cyclin D1	pRb	595	5925	Gene	Gene	overexpression|amod|START_ENTITY value|nmod|overexpression value|nmod|status status|compound|END_ENTITY	Prognostic value of cyclin_D1 overexpression in correlation with pRb and p53 status in non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
17699765	0	cyclin_D1	36,45	pRb	10,13	cyclin D1	pRb	12443(Tax:10090)	19645(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The LxCxE pRb interaction domain of cyclin_D1 is dispensable for murine development .
7553644	0	cyclin_D1	89,98	proliferating_cell_nuclear_antigen	139,173	cyclin D1	proliferating cell nuclear antigen	595	5111	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Immortalization of human fibroblasts by SV40 large T antigen results in the reduction of cyclin_D1 expression and subunit association with proliferating_cell_nuclear_antigen and Waf1 .
12151312	0	cyclin_D1	35,44	protein_kinase_C-delta	62,84	cyclin D1	protein kinase C-delta	524530(Tax:9913)	505708(Tax:9913)	Gene	Gene	Regulation|nmod|START_ENTITY transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of airway smooth muscle cyclin_D1 transcription by protein_kinase_C-delta .
22581837	0	cyclin_D1	106,115	transcriptional_intermediary_factor_2	56,93	cyclin D1	transcriptional intermediary factor 2	595	10499	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Nuclear epidermal_growth_factor_receptor interacts with transcriptional_intermediary_factor_2 to activate cyclin_D1 gene expression triggered by the oncoprotein latent_membrane_protein_1 .
25225463	0	cyclin_D1	113,122	vascular_endothelial_growth_factor	59,93	cyclin D1	vascular endothelial growth factor	595	7422	Gene	Gene	epidermal|amod|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
16410729	0	cyclin_D2	63,72	Cdk4	73,77	cyclin D2	Cdk4	894	1019	Gene	Gene	START_ENTITY|parataxis|dependent dependent|dep|END_ENTITY	Beta-cell growth : an unusual paradigm of organogenesis that is cyclin_D2 / Cdk4 dependent .
22323446	0	cyclin_D2	28,37	FBXL2	14,19	cyclin D2	FBXL2	894	25827	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	F-box protein FBXL2 targets cyclin_D2 for ubiquitination and degradation to inhibit leukemic cell proliferation .
15509806	0	cyclin_D2	28,37	FoxO3a	0,6	cyclin D2	FoxO3a	894	2309	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	FoxO3a and BCR-ABL regulate cyclin_D2 transcription through a STAT5/BCL6-dependent mechanism .
12370811	0	cyclin_D2	23,32	Kip1	41,45	cyclin D2	Kip1	12444(Tax:10090)	12576(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Functional analysis of cyclin_D2 and p27 -LRB- Kip1 -RRB- in cyclin_D2 transgenic mouse mammary gland during development .
7636179	0	cyclin_D2	34,43	Latent_membrane_protein-1	0,25	cyclin D2	Latent membrane protein-1	894	9260	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Latent_membrane_protein-1 induces cyclin_D2 expression , pRb hyperphosphorylation , and loss of TGF-beta_1-mediated growth inhibition in EBV-positive B cells .
16182291	0	cyclin_D2	54,63	Mel-18	32,38	cyclin D2	Mel-18	894	7703	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The polycomb group gene product Mel-18 interacts with cyclin_D2 and modulates its activity .
18504428	0	cyclin_D2	18,27	NF-kappaB	51,60	cyclin D2	NF-kappaB	894	4790	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Activation of the cyclin_D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax .
16114097	0	cyclin_D2	80,89	Phosphatidylinositol_3-kinase	0,29	cyclin D2	Phosphatidylinositol 3-kinase	12444(Tax:10090)	18708(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Phosphatidylinositol_3-kinase is required for the transcriptional activation of cyclin_D2 in BCR activated primary mouse B lymphocytes .
20372070	0	cyclin_D2	78,87	Pituitary_homeobox_2	0,20	cyclin D2	Pituitary homeobox 2	894	5308	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Pituitary_homeobox_2 -LRB- PITX2 -RRB- promotes thyroid_carcinogenesis by activation of cyclin_D2 .
11314046	0	cyclin_D2	37,46	Tax	76,79	cyclin D2	Tax	894	6900	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Direct trans-activation of the human cyclin_D2 gene by the oncogene product Tax of human_T-cell_leukemia_virus_type_I .
11358847	0	cyclin_D2	43,52	cyclin-dependent_kinase_4	17,42	cyclin D2	cyclin-dependent kinase 4	894	1019	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Up-regulation of cyclin-dependent_kinase_4 / cyclin_D2 expression but down-regulation of cyclin-dependent_kinase_2 / cyclin E in testicular germ_cell_tumors .
17560576	0	cyclin_D2	70,79	cyclin_D1	127,136	cyclin D2	cyclin D1	12444(Tax:10090)	12443(Tax:10090)	Gene	Gene	localization|amod|START_ENTITY localization|nmod|END_ENTITY	GSK-3beta mediates in the progesterone inhibition of estrogen induced cyclin_D2 nuclear localization and cell proliferation in cyclin_D1 - / - mouse uterine epithelium .
14660677	0	cyclin_D2	88,97	interleukin-2	105,118	cyclin D2	interleukin-2	894	3558	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin_D2 by the interleukin-2 receptor .
16084951	0	cyclin_D3	27,36	ALK	40,43	cyclin D3	ALK	896	238	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential expression of cyclin_D3 in ALK + and ALK - anaplastic_large_cell_lymphoma .
16287839	0	cyclin_D3	102,111	AML1	39,43	cyclin D3	AML1	896	861	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The hematopoietic transcription factor AML1 -LRB- RUNX1 -RRB- is negatively regulated by the cell cycle protein cyclin_D3 .
1387066	0	cyclin_D3	24,33	CCND3	40,45	cyclin D3	CCND3	896	896	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human cyclin_D3 gene -LRB- CCND3 -RRB- to chromosome 6p -- q13 .
18183592	0	cyclin_D3	97,106	CDK6	107,111	cyclin D3	CDK6	896	1021	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	Pure antiestrogen-induced G1-arrest in myeloma cells results from the reduced kinase activity of cyclin_D3 / CDK6 complexes whereas apoptosis is mediated by endoplasmic reticulum-dependent caspases .
15252116	0	cyclin_D3	28,37	GSK-3beta	63,72	cyclin D3	GSK-3beta	896	2932	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	cAMP-induced degradation of cyclin_D3 through association with GSK-3beta .
17881769	0	cyclin_D3	15,24	Survivin	51,59	cyclin D3	Survivin	12445(Tax:10090)	11799(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of cyclin_D3 , CDKN1A -LRB- p21 -RRB- , and BIRC5 -LRB- Survivin -RRB- in interleukin_11 stimulation of decidualization in mice .
10849422	0	cyclin_D3	36,45	c-kit	17,22	cyclin D3	c-kit	896	3815	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Stem_cell_factor / c-kit up-regulates cyclin_D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 _ S6_kinase pathway in spermatogonia .
22214766	0	cyclin_D3	19,28	cyclin_D1	58,67	cyclin D3	cyclin D1	12445(Tax:10090)	12443(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Combined effect of cyclin_D3 expression and abrogation of cyclin_D1 prevent mouse skin_tumor development .
12082095	0	cyclin_D3	66,75	p58	15,18	cyclin D3	p58	896	984	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of p58 -LRB- PITSLRE -RRB- , a G2/M-specific protein kinase , with cyclin_D3 .
10573135	0	cyclin_D3	45,54	pRB	23,26	cyclin D3	pRB	896	5925	Gene	Gene	Hypophosphorylation|nmod|START_ENTITY Hypophosphorylation|nmod|END_ENTITY	Hypophosphorylation of pRB and repression of cyclin_D3 and cdc25A during the granulocytic differentiation of human myeloblastic_leukemia ML-1 cells .
10573136	0	cyclin_D3	45,54	pRB	23,26	cyclin D3	pRB	896	5925	Gene	Gene	Hypophosphorylation|nmod|START_ENTITY Hypophosphorylation|nmod|END_ENTITY	Hypophosphorylation of pRB and repression of cyclin_D3 and cdc25A during the granulocytic differentiation of human myeloblastic_leukemia ML-1 cells .
16303160	0	cyclin_D3	81,90	pRb	91,94	cyclin D3	pRb	896	5925	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	SARS_coronavirus 7a protein blocks cell cycle progression at G0/G1 phase via the cyclin_D3 / pRb pathway .
22713240	0	cyclin_E	18,26	CDK2	27,31	cyclin E	CDK2	25729(Tax:10116)	362817(Tax:10116)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|parataxis|overcomes overcomes|nsubj|complexes complexes|compound|END_ENTITY	Overexpression of cyclin_E / CDK2 complexes overcomes FGF-induced cell cycle arrest in the presence of hypophosphorylated Rb proteins .
10790398	0	cyclin_E	26,34	Cdk2	164,168	cyclin E	Cdk2	34924(Tax:7227)	42453(Tax:7227)	Gene	Gene	function|amod|START_ENTITY modifiers|nmod|function screen|nmod|modifiers identifies|nsubj|screen identifies|advcl|revealing revealing|nmod|END_ENTITY	A screen for modifiers of cyclin_E function in Drosophila_melanogaster identifies Cdk2 mutations , revealing the insignificance of putative phosphorylation sites in Cdk2 .
10790398	0	cyclin_E	26,34	Cdk2	82,86	cyclin E	Cdk2	34924(Tax:7227)	42453(Tax:7227)	Gene	Gene	function|amod|START_ENTITY modifiers|nmod|function screen|nmod|modifiers identifies|nsubj|screen identifies|dobj|mutations mutations|amod|END_ENTITY	A screen for modifiers of cyclin_E function in Drosophila_melanogaster identifies Cdk2 mutations , revealing the insignificance of putative phosphorylation sites in Cdk2 .
12149264	0	cyclin_E	26,34	Cdk2	54,58	cyclin E	Cdk2	25729(Tax:10116)	362817(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY confined|nsubjpass|activity confined|nmod|activation activation|amod|END_ENTITY	The oncogenic activity of cyclin_E is not confined to Cdk2 activation alone but relies on several other , distinct functions of the protein .
12914904	0	cyclin_E	23,31	Cdk2	32,36	cyclin E	Cdk2	397841(Tax:8355)	399314(Tax:8355)	Gene	Gene	model|nmod|START_ENTITY model|dep|timer timer|amod|END_ENTITY	A kinetic model of the cyclin_E / Cdk2 developmental timer in Xenopus_laevis embryos .
18414041	0	cyclin_E	111,119	Cdk2	120,124	cyclin E	Cdk2	397841(Tax:8355)	399314(Tax:8355)	Gene	Gene	timer|amod|START_ENTITY timer|amod|END_ENTITY	Chk1 is activated at the midblastula_transition in Xenopus_laevis embryos independently of DNA content and the cyclin_E / Cdk2 developmental timer .
9268577	0	cyclin_E	11,19	Cdk2	20,24	cyclin E	Cdk2	397841(Tax:8355)	399314(Tax:8355)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for cyclin_E / Cdk2 in the timing of the midblastula_transition in Xenopus embryos .
11025208	0	cyclin_E	75,83	Dacapo	52,58	cyclin E	Dacapo	34924(Tax:7227)	36001(Tax:7227)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin_E .
8675008	0	cyclin_E	76,84	E2F	44,47	cyclin E	E2F	34924(Tax:7227)	42550(Tax:7227)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	RBF , a novel RB-related gene that regulates E2F activity and interacts with cyclin_E in Drosophila .
26184774	0	cyclin_E	172,180	glycogen_synthase_kinase_3b	114,141	cyclin E	glycogen synthase kinase 3b	25729(Tax:10116)	84027(Tax:10116)	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen_synthase_kinase_3b and subsequent degradation of cyclin_E in rats .
10597246	0	cyclin_E	97,105	p21	71,74	cyclin E	p21	25729(Tax:10116)	24525(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin_E expression .
16912169	0	cyclin_E1	19,28	HuR	0,3	cyclin E1	HuR	898	1994	Gene	Gene	deregulation|amod|START_ENTITY contributes|nmod|deregulation contributes|nsubj|END_ENTITY	HuR contributes to cyclin_E1 deregulation in MCF-7 breast_cancer cells .
23378270	0	cyclin_E1	55,64	Rsf-1	0,5	cyclin E1	Rsf-1	25729(Tax:10116)	308839(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rsf-1 , a chromatin remodelling protein , interacts with cyclin_E1 and promotes tumour development .
19944013	0	cyclin_E1	23,32	microRNA-16-1	56,69	cyclin E1	microRNA-16-1	898	406950	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of the cyclin_E1 oncogene expression by microRNA-16-1 induces cell cycle arrest in human cancer cells .
25550809	0	cyclin_E2	85,94	MicroRNA-25	0,11	cyclin E2	MicroRNA-25	9134	407014	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-25 regulates small_cell_lung_cancer cell development and cell cycle through cyclin_E2 .
19084516	0	cyclin_E2	25,34	SCF	0,3	cyclin E2	SCF	9134	4254	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	SCF -LRB- Fbxw7/hCdc4 -RRB- targets cyclin_E2 for ubiquitin-dependent proteolysis .
17487067	0	cyclin_G	69,77	P53	47,50	cyclin G	P53	25405(Tax:10116)	301300(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|protection protection|nmod|PCNA PCNA|compound|END_ENTITY	Differential protection and transactivation of P53 , P21 , Bcl2 , PCNA , cyclin_G , and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin .
10196184	0	cyclin_G	22,30	p53	133,136	cyclin G	p53	900	7157	Gene	Gene	START_ENTITY|nmod|damage damage|nmod|+ +|compound|END_ENTITY	Altered regulation of cyclin_G in human breast_cancer and its specific localization at replication foci in response to DNA damage in p53 + / + cells .
12642871	0	cyclin_G	36,44	p53	14,17	cyclin G	p53	900	7157	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Modulation of p53 and p73 levels by cyclin_G : implication of a negative feedback regulation .
15077171	0	cyclin_G	21,29	p53	47,50	cyclin G	p53	900	7157	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	The negative role of cyclin_G in ATM-dependent p53 activation .
7784084	0	cyclin_G	80,88	p53	116,119	cyclin G	p53	25405(Tax:10116)	301300(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY contains|nsubj|gene contains|dobj|sites sites|nummod|END_ENTITY	Identification of p53 target genes through immune selection of genomic DNA : the cyclin_G gene contains two distinct p53 binding sites .
7784084	0	cyclin_G	80,88	p53	18,21	cyclin G	p53	25405(Tax:10116)	301300(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY contains|nsubj|gene target|parataxis|contains target|nsubj|Identification Identification|nmod|END_ENTITY	Identification of p53 target genes through immune selection of genomic DNA : the cyclin_G gene contains two distinct p53 binding sites .
9013707	0	cyclin_G	18,26	p53	54,57	cyclin G	p53	900	7157	Gene	Gene	gene|compound|START_ENTITY promotes|nsubj|gene promotes|parataxis|cyclin_G cyclin_G|nsubj|effectors effectors|nummod|END_ENTITY	The p53-regulated cyclin_G gene promotes cell growth : p53 downstream effectors cyclin_G and Gadd45 exert different effects on cisplatin chemosensitivity .
9013707	0	cyclin_G	79,87	p53	54,57	cyclin G	p53	900	7157	Gene	Gene	START_ENTITY|nsubj|effectors effectors|nummod|END_ENTITY	The p53-regulated cyclin_G gene promotes cell growth : p53 downstream effectors cyclin_G and Gadd45 exert different effects on cisplatin chemosensitivity .
15240878	0	cyclin_G-associated_kinase	28,54	epidermal_growth_factor_receptor	65,97	cyclin G-associated kinase	epidermal growth factor receptor	2580	1956	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The serine/threonine kinase cyclin_G-associated_kinase regulates epidermal_growth_factor_receptor signaling .
7585620	0	cyclin_G1	54,63	CYCG1	65,70	cyclin G1	CYCG1	900	900	Gene	Gene	transfer|nmod|START_ENTITY transfer|appos|END_ENTITY	Retroviral vector-mediated gene transfer of antisense cyclin_G1 -LRB- CYCG1 -RRB- inhibits proliferation of human osteogenic_sarcoma cells .
25309979	0	cyclin_G2	22,31	MicroRNA-93	0,11	cyclin G2	MicroRNA-93	901	407051	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-93 regulates cyclin_G2 expression and plays an oncogenic role in laryngeal_squamous_cell_carcinoma .
16608856	0	cyclin_G2	46,55	estrogen_receptor	18,35	cyclin G2	estrogen receptor	901	2099	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Estrogen-occupied estrogen_receptor represses cyclin_G2 gene expression and recruits a repressor complex at the cyclin_G2 promoter .
11319144	0	cyclin_H	26,34	Cdk7	35,39	cyclin H	Cdk7	66671(Tax:10090)	12572(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Meiotic expression of the cyclin_H / Cdk7 complex in male germ cells of the mouse .
9029154	0	cyclin_H	68,76	cdk7	38,42	cyclin H	cdk7	394356(Tax:8355)	399461(Tax:8355)	Gene	Gene	role|nmod|START_ENTITY phosphorylation|dep|role phosphorylation|nmod|T-loop T-loop|nmod|END_ENTITY	Dual phosphorylation of the T-loop in cdk7 : its role in controlling cyclin_H binding and CAK activity .
17287831	0	cyclin_H	28,36	cyclin_H	82,90	cyclin H	cyclin H	541325(Tax:7955)	541325(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Developmental expression of cyclin_H and Cdk7 in zebrafish : the essential role of cyclin_H during early embryo development .
17287831	0	cyclin_H	82,90	cyclin_H	28,36	cyclin H	cyclin H	541325(Tax:7955)	541325(Tax:7955)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Developmental expression of cyclin_H and Cdk7 in zebrafish : the essential role of cyclin_H during early embryo development .
26469956	0	cyclin_J	37,45	HOTAIR	20,26	cyclin J	HOTAIR	54619	100124700	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Long non-coding RNA HOTAIR regulates cyclin_J via inhibition of microRNA-205 expression in bladder_cancer .
11689688	0	cyclin_T1	20,29	SKP2	38,42	cyclin T1	SKP2	904	6502	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction between cyclin_T1 and SCF -LRB- SKP2 -RRB- targets CDK9 for ubiquitination and degradation by the proteasome .
18362169	0	cyclin_T1	136,145	cyclin-dependent_kinase_9	110,135	cyclin T1	cyclin-dependent kinase 9	12455(Tax:10090)	107951(Tax:10090)	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent_kinase_9 / cyclin_T1 complexes .
21555514	0	cyclin_T1	109,118	cyclin-dependent_kinase_9	76,101	cyclin T1	cyclin-dependent kinase 9	904	1025	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent_kinase_9 -LRB- CDK9 -RRB- - cyclin_T1 interaction in Nef-dependent manner .
12588988	0	cyclin_T1	42,51	granulin	18,26	cyclin T1	granulin	904	2896	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The growth factor granulin interacts with cyclin_T1 and modulates P-TEFb-dependent transcription .
21609829	0	cyclin_Y	6,14	CYY-1	0,5	cyclin Y	CYY-1	176188(Tax:6239)	176188(Tax:6239)	Gene	Gene	/|amod|START_ENTITY /|compound|END_ENTITY	CYY-1 / cyclin_Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits .
24824184	0	cyclin_Y	21,29	PFTK1	0,5	cyclin Y	PFTK1	219771	5218	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PFTK1 interacts with cyclin_Y to activate non-canonical Wnt signaling in hepatocellular_carcinoma .
11160720	0	cyclin_a	33,41	Tax	80,83	cyclin a	Tax	890	6900	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|protein protein|compound|END_ENTITY	CREB/ATF-dependent repression of cyclin_a by human_T-cell_leukemia_virus_type_1 Tax protein .
15173007	0	cyclin_a	39,47	cyclin-dependent_kinase_2	48,73	cyclin a	cyclin-dependent kinase 2	890	1017	Gene	Gene	destruction|nmod|START_ENTITY destruction|parataxis|suppresses suppresses|nsubj|complex complex|amod|END_ENTITY	Proteasome-mediated destruction of the cyclin_a / cyclin-dependent_kinase_2 complex suppresses tumor cell growth in vitro and in vivo .
17636382	0	cyclin_a	71,79	cyclin_dependent_kinase_1	45,70	cyclin a	cyclin dependent kinase 1	890	983	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	New alternative phosphorylation sites on the cyclin_dependent_kinase_1 / cyclin_a complex in p53-deficient human cells treated with etoposide : possible association with etoposide-induced apoptosis .
16601140	0	cyclin_d1	16,25	cdk4	26,30	cyclin d1	cdk4	595	1019	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|subtype subtype|nsubj|END_ENTITY	Role of complex cyclin_d1 / cdk4 in somatostatin subtype 2 receptor-mediated inhibition of cell proliferation of a medullary_thyroid_carcinoma cell line in vitro .
16870444	0	cyclin_dependent_kinase_1	55,80	CDK1	82,86	cyclin dependent kinase 1	CDK1	983	983	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis of 2-amino-4 - -LRB- 7-azaindol-3-yl -RRB- pyrimidines as cyclin_dependent_kinase_1 -LRB- CDK1 -RRB- inhibitors .
17234412	0	cyclin_dependent_kinase_1	90,115	CDK1	117,121	cyclin dependent kinase 1	CDK1	983	983	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Synthesis of 3 - -LRB- 1H-benzimidazol-2-yl -RRB- -5 - isoquinolin-4-ylpyrazolo -LSB- 1,2-b -RSB- pyridine , a potent cyclin_dependent_kinase_1 -LRB- CDK1 -RRB- inhibitor .
18232654	0	cyclin_dependent_kinase_1	38,63	CDK1	65,69	cyclin dependent kinase 1	CDK1	983	983	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Pyrrolo -LSB- 2,3-a -RSB- carbazoles as potential cyclin_dependent_kinase_1 -LRB- CDK1 -RRB- Inhibitors .
17636382	0	cyclin_dependent_kinase_1	45,70	cyclin_a	71,79	cyclin dependent kinase 1	cyclin a	983	890	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	New alternative phosphorylation sites on the cyclin_dependent_kinase_1 / cyclin_a complex in p53-deficient human cells treated with etoposide : possible association with etoposide-induced apoptosis .
10825132	0	cyclin_dependent_kinase_4	18,43	p16INK4A	0,8	cyclin dependent kinase 4	p16INK4A	1019	1029	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	p16INK4A mediates cyclin_dependent_kinase_4 and 6 inhibition in senescent prostatic epithelial cells .
24662752	0	cyclin_dependent_kinase_5	22,47	sox6	14,18	cyclin dependent kinase 5	sox6	12568(Tax:10090)	20679(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of sox6 by cyclin_dependent_kinase_5 in brain .
21550420	0	cyclin_dependent_kinases_1_and_2	48,80	progesterone_receptor	14,35	cyclin dependent kinases 1 and 2	progesterone receptor	983;1017	5241	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of progesterone_receptor activity by cyclin_dependent_kinases_1_and_2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus .
11686835	0	cyclo-oxygenase-2	26,43	Interleukin-1beta	0,17	cyclo-oxygenase-2	Interleukin-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric_cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways .
11487528	0	cyclo-oxygenase-2	13,30	SIN-1	61,66	cyclo-oxygenase-2	SIN-1	5743	79109	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production .
12162497	0	cyclo-oxygenase_2	37,54	Bone_morphogenetic_protein_2	0,28	cyclo-oxygenase 2	Bone morphogenetic protein 2	19225(Tax:10090)	12156(Tax:10090)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Bone_morphogenetic_protein_2 induces cyclo-oxygenase_2 in osteoblasts via a Cbfal binding site : role in effects of bone_morphogenetic_protein_2 in vitro and in vivo .
12162497	0	cyclo-oxygenase_2	37,54	bone_morphogenetic_protein_2	115,143	cyclo-oxygenase 2	bone morphogenetic protein 2	19225(Tax:10090)	12156(Tax:10090)	Gene	Gene	induces|xcomp|START_ENTITY induces|dobj|role role|nmod|effects effects|nmod|END_ENTITY	Bone_morphogenetic_protein_2 induces cyclo-oxygenase_2 in osteoblasts via a Cbfal binding site : role in effects of bone_morphogenetic_protein_2 in vitro and in vivo .
11122255	0	cyclooxygenase-1	14,30	COX-1	32,37	cyclooxygenase-1	COX-1	5742	5742	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cyclooxygenase-1 -LRB- COX-1 -RRB- in labial salivary glands of Sj gren 's _ syndrome .
17202703	0	cyclooxygenase-1	72,88	COX-1	90,95	cyclooxygenase-1	COX-1	5742	5742	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 -LRB- COX-1 -RRB- inhibitors .
21372527	0	cyclooxygenase-1	36,52	COX-1	54,59	cyclooxygenase-1	COX-1	5742	5742	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Significance and creation of novel cyclooxygenase-1 -LRB- COX-1 -RRB- selective inhibitors -RSB- .
11409489	0	cyclooxygenase-1	43,59	COX-2	90,95	cyclooxygenase-1	COX-2	282022(Tax:9913)	282023(Tax:9913)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	In-vitro test system for the evaluation of cyclooxygenase-1 -LRB- COX-1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors based on a single HPLC run with UV detection using bovine aortic coronary endothelial cells -LRB- BAECs -RRB- .
10381787	0	cyclooxygenase-1	38,54	cyclooxygenase-2	68,84	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	platelet|amod|START_ENTITY inhibition|nmod|platelet inhibition|amod|END_ENTITY	Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects .
10821698	0	cyclooxygenase-1	94,110	cyclooxygenase-2	150,166	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	diarylheterocycle|nmod|START_ENTITY association|nmod|diarylheterocycle analysis|nmod|association analysis|dep|basis basis|nmod|selectivity selectivity|amod|END_ENTITY	Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2 : dynamic basis of cyclooxygenase-2 selectivity .
11310210	0	cyclooxygenase-1	26,42	cyclooxygenase-2	58,74	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Interferon-alpha inhibits cyclooxygenase-1 and stimulates cyclooxygenase-2 expression in bladder_cancer cells in vitro .
11717412	0	cyclooxygenase-1	109,125	cyclooxygenase-2	16,32	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	inactivation|amod|START_ENTITY interference|nmod|inactivation associated|nmod|interference associated|nsubjpass|level level|nmod|inhibitor inhibitor|amod|END_ENTITY	A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin .
11752370	0	cyclooxygenase-1	92,108	cyclooxygenase-2	28,44	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	inhibitor|amod|START_ENTITY reaction|nmod|inhibitor had|dobj|reaction patient|acl:relcl|had inhibitor|nmod|patient inhibitor|amod|END_ENTITY	Anaphylactoid reaction to a cyclooxygenase-2 inhibitor in a patient who had a reaction to a cyclooxygenase-1 inhibitor .
11853875	0	cyclooxygenase-1	87,103	cyclooxygenase-2	67,83	cyclooxygenase-1	cyclooxygenase-2	19224(Tax:10090)	19225(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	The involvement of NF-kappaB in the constitutive overexpression of cyclooxygenase-2 in cyclooxygenase-1 null cells .
11861778	0	cyclooxygenase-1	51,67	cyclooxygenase-2	17,33	cyclooxygenase-1	cyclooxygenase-2	24693(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1 : a key to nonsteroidal anti-inflammatory drug-induced intestinal_damage .
11959090	0	cyclooxygenase-1	11,27	cyclooxygenase-2	28,44	cyclooxygenase-1	cyclooxygenase-2	24693(Tax:10116)	29527(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|inhibition inhibition|amod|END_ENTITY	Effects of cyclooxygenase-1 / cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery .
12708469	0	cyclooxygenase-1	68,84	cyclooxygenase-2	19,35	cyclooxygenase-1	cyclooxygenase-2	24693(Tax:10116)	29527(Tax:10116)	Gene	Gene	model|amod|START_ENTITY Down-regulation|nmod|model Down-regulation|nmod|expression expression|amod|END_ENTITY	Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal_carcinomas of the Eker -LRB- TSC2 gene mutant -RRB- rat model .
12743620	0	cyclooxygenase-1	103,119	cyclooxygenase-2	79,95	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	A model with original conditions and materials to test potential inhibitors of cyclooxygenase-2 versus cyclooxygenase-1 in isolated human blood cells .
14701858	0	cyclooxygenase-1	96,112	cyclooxygenase-2	46,62	cyclooxygenase-1	cyclooxygenase-2	19224(Tax:10090)	19225(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup .
15963707	0	cyclooxygenase-1	73,89	cyclooxygenase-2	95,111	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	regulated|advcl|START_ENTITY regulated|xcomp|END_ENTITY	Prostaglandin_E2 production in ovarian_cancer cell lines is regulated by cyclooxygenase-1 , not cyclooxygenase-2 .
16675095	0	cyclooxygenase-1	93,109	cyclooxygenase-2	64,80	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	not|nmod|START_ENTITY END_ENTITY|dep|not	Isosorbide_mononitrate induces increased cervical expression of cyclooxygenase-2 , but not of cyclooxygenase-1 , at term .
17915854	1	cyclooxygenase-1	150,166	cyclooxygenase-2	103,119	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	1,5-diarylpyrrol-3-acetic _ esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2 / cyclooxygenase-1 selectivity .
17915854	1	cyclooxygenase-1	150,166	cyclooxygenase-2	133,149	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	1,5-diarylpyrrol-3-acetic _ esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2 / cyclooxygenase-1 selectivity .
18349208	0	cyclooxygenase-1	39,55	cyclooxygenase-2	69,85	cyclooxygenase-1	cyclooxygenase-2	24693(Tax:10116)	29527(Tax:10116)	Gene	Gene	incisions|amod|START_ENTITY incisions|amod|END_ENTITY	Upregulation of dorsal horn microglial cyclooxygenase-1 and neuronal cyclooxygenase-2 after thoracic deep muscle incisions in the rat .
21301321	0	cyclooxygenase-1	17,33	cyclooxygenase-2	64,80	cyclooxygenase-1	cyclooxygenase-2	5742	5743	Gene	Gene	expression|amod|START_ENTITY influence|nmod|expression influence|nmod|efficacy efficacy|nmod|inhibition inhibition|amod|END_ENTITY	The influence of cyclooxygenase-1 expression on the efficacy of cyclooxygenase-2 inhibition in head_and_neck_squamous_cell_carcinoma cell lines .
11877441	0	cyclooxygenase-1	30,46	histone_deacetylase	50,69	cyclooxygenase-1	histone deacetylase	5742	9734	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Transcriptional regulation of cyclooxygenase-1 by histone_deacetylase inhibitors in normal human astrocyte cells .
7872783	0	cyclooxygenase-1	63,79	prostaglandin_endoperoxide_synthase-1	24,61	cyclooxygenase-1	prostaglandin endoperoxide synthase-1	19224(Tax:10090)	19224(Tax:10090)	Gene	Gene	inhibition|dep|START_ENTITY inhibition|nmod|END_ENTITY	Selective inhibition of prostaglandin_endoperoxide_synthase-1 -LRB- cyclooxygenase-1 -RRB- by valerylsalicylic_acid .
20615388	0	cyclooxygenase-2	14,30	AICAR	0,5	cyclooxygenase-2	AICAR	5743	471	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	AICAR induces cyclooxygenase-2 expression through AMP-activated_protein_kinase-transforming growth factor-beta-activated kinase 1-p38_mitogen-activated_protein_kinase signaling pathway .
21734188	0	cyclooxygenase-2	33,49	ATP-binding_cassette_transporter_A1	120,155	cyclooxygenase-2	ATP-binding cassette transporter A1	5743	19	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Human apolipoprotein_A-I induces cyclooxygenase-2 expression and prostaglandin_I-2 release in endothelial cells through ATP-binding_cassette_transporter_A1 .
23376640	0	cyclooxygenase-2	56,72	Akt	108,111	cyclooxygenase-2	Akt	5743	207	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Gastrin acting on the cholecystokinin2_receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K / Akt pathway in human gastric_cancer cells .
10194467	0	cyclooxygenase-2	41,57	Angiotensin_II	0,14	cyclooxygenase-2	Angiotensin II	29527(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Angiotensin_II attenuates renal cortical cyclooxygenase-2 expression .
11880319	0	cyclooxygenase-2	26,42	Angiotensin_II	0,14	cyclooxygenase-2	Angiotensin II	29527(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates cyclooxygenase-2 mRNA expression in renal tissue from rats with kidney_failure .
12388637	0	cyclooxygenase-2	39,55	Angiotensin_II	0,14	cyclooxygenase-2	Angiotensin II	5743	183	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases expression of cyclooxygenase-2 : implications for the function of vascular smooth muscle cells .
15525649	0	cyclooxygenase-2	50,66	Angiotensin_II	0,14	cyclooxygenase-2	Angiotensin II	29527(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Angiotensin_II and epidermal_growth_factor induce cyclooxygenase-2 expression in intestinal epithelial cells through small GTPases using distinct signaling pathways .
18543083	0	cyclooxygenase-2	42,58	Angiotensin_II	0,14	cyclooxygenase-2	Angiotensin II	29527(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II bi-directionally regulates cyclooxygenase-2 expression in intestinal epithelial cells .
21169864	0	cyclooxygenase-2	40,56	Angiotensin_II	0,14	cyclooxygenase-2	Angiotensin II	29527(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Angiotensin_II differentially modulates cyclooxygenase-2 , microsomal prostaglandin_E2 synthase-1 and prostaglandin_I2 synthase expression in adventitial fibroblasts exposed to inflammatory stimuli .
25225463	0	cyclooxygenase-2	95,111	Bcl2	53,57	cyclooxygenase-2	Bcl2	5743	596	Gene	Gene	epidermal|amod|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
16909108	0	cyclooxygenase-2	17,33	Bombesin	0,8	cyclooxygenase-2	Bombesin	5743	2922	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon_carcinoma cells .
11352510	0	cyclooxygenase-2	27,43	Bradykinin	0,10	cyclooxygenase-2	Bradykinin	5743	3827	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Bradykinin induces a rapid cyclooxygenase-2 mRNA expression via Ca2 + mobilization in human gingival fibroblasts primed with interleukin-1_beta .
15447673	0	cyclooxygenase-2	13,29	CD40	61,65	cyclooxygenase-2	CD40	19225(Tax:10090)	21939(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|pathway pathway|compound|END_ENTITY	Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway : relevance to amyotrophic_lateral_sclerosis .
19636412	0	cyclooxygenase-2	34,50	CD47	0,4	cyclooxygenase-2	CD47	5743	961	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration .
10561943	0	cyclooxygenase-2	17,33	COX-2	35,40	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	The induction of cyclooxygenase-2 -LRB- COX-2 -RRB- in cultured endothelial cells treated with serum from preeclampsia is mediated by interleukin-6 .
10611376	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- in rat renal cortex by adrenal glucocorticoids and mineralocorticoids .
10639181	0	cyclooxygenase-2	30,46	COX-2	48,53	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Biochemically based design of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors .
10667110	0	cyclooxygenase-2	11,27	COX-2	29,34	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : importance and limitations -RSB- .
10942208	0	cyclooxygenase-2	57,73	COX-2	75,80	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activation of NFkappaB is necessary for IL-1beta-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human_gingival_fibroblasts .
10974444	0	cyclooxygenase-2	34,50	COX-2	52,57	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Radiation induces upregulation of cyclooxygenase-2 -LRB- COX-2 -RRB- protein in PC-3 cells .
11275997	0	cyclooxygenase-2	78,94	COX-2	96,101	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tumor invasiveness and liver metastasis of colon_cancer cells correlated with cyclooxygenase-2 -LRB- COX-2 -RRB- expression and inhibited by a COX-2-selective inhibitor , etodolac .
11350912	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in hepatocellular_carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor , NS-398 .
11506952	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA in human colorectal_adenomas .
11520213	0	cyclooxygenase-2	71,87	COX-2	89,94	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere .
11563332	0	cyclooxygenase-2	15,31	COX-2	33,38	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	site|amod|START_ENTITY site|compound|END_ENTITY	Recognition of cyclooxygenase-2 -LRB- COX-2 -RRB- active site by NSAIDs : a computer modelling study .
11566484	0	cyclooxygenase-2	23,39	COX-2	41,46	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Specific inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- expression by dietary curcumin in HT-29 human colon_cancer cells .
11584358	0	cyclooxygenase-2	27,43	COX-2	45,50	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in human bile duct epithelial cells and bile_duct_neoplasm .
11911832	0	cyclooxygenase-2	10,26	COX-2	28,33	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors and potential risk of cardiovascular events .
11917005	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Post-training cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition impairs memory consolidation .
12151354	0	cyclooxygenase-2	12,28	COX-2	30,35	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of cyclooxygenase-2 -LRB- COX-2 -RRB- in two different morphological stages of intestinal_polyps in APC -LRB- Delta474 -RRB- knockout mice .
12181243	0	cyclooxygenase-2	10,26	COX-2	28,33	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Increased cyclooxygenase-2 -LRB- COX-2 -RRB- expression is associated with chemotherapy resistance and outcome in ovarian_cancer patients .
12361181	0	cyclooxygenase-2	48,64	COX-2	66,71	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Use of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : indications and complications .
12431470	0	cyclooxygenase-2	12,28	COX-2	30,35	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of cyclooxygenase-2 -LRB- COX-2 -RRB- in breast_cancer , and implications of COX-2 inhibition .
12434137	0	cyclooxygenase-2	11,27	COX-2	29,34	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Effects of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on plasma and renal renin in diabetes .
12537697	0	cyclooxygenase-2	79,95	COX-2	97,102	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the interferon regulatory factors , IRF-1 and IRF-2 , in LPS-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vivo and in vitro .
12565135	0	cyclooxygenase-2	84,100	COX-2	102,107	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Activation of the peripheral sympathetic nervous system increased the expression of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA in mouse calvaria .
14604691	0	cyclooxygenase-2	63,79	COX-2	81,86	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere .
14666698	0	cyclooxygenase-2	10,26	COX-2	28,33	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors on prostate_cancer cell proliferation .
14747187	0	cyclooxygenase-2	12,28	COX-2	30,35	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in different sites of endometriosis and correlation with clinico-pathological parameters .
14766245	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in non-neoplastic and neoplastic vulvar_epithelial_lesions .
15026050	0	cyclooxygenase-2	110,126	COX-2	128,133	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15050635	0	cyclooxygenase-2	71,87	COX-2	89,94	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design of acyclic triaryl_olefins : a new class of potent and selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15202549	0	cyclooxygenase-2	45,61	COX-2	63,68	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	CoMFA and CoMSIA 3D QSAR studies on pimarane cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15221958	0	cyclooxygenase-2	68,84	COX-2	86,91	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fibronectin stimulates human lung_carcinoma cell growth by inducing cyclooxygenase-2 -LRB- COX-2 -RRB- expression .
15498669	0	cyclooxygenase-2	70,86	COX-2	88,93	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design and synthesis of acyclic_triaryl _ -LRB- Z -RRB- - olefins : a novel class of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15655349	0	cyclooxygenase-2	27,43	COX-2	45,50	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
15678189	0	cyclooxygenase-2	26,42	COX-2	44,49	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis of 18F-labelled cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors via Stille reaction with 4 - -LSB- 18F -RSB- fluoroiodobenzene as radiotracers for positron emission tomography -LRB- PET -RRB- .
15755648	0	cyclooxygenase-2	104,120	COX-2	122,127	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design , synthesis , and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides : a novel class of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
15816526	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	The effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on human prostate_cancer induced osteoblastic and osteolytic_lesions in bone .
15930344	0	cyclooxygenase-2	10,26	COX-2	149,154	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial_adenomatous_polyposis and relationship to the -765 G _ - > _ C COX-2 polymorphism .
16044407	0	cyclooxygenase-2	26,42	COX-2	44,49	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of TPA-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin through downregulation of Akt signal transduction in human keratinocytes .
16123787	0	cyclooxygenase-2	26,42	COX-2	44,49	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The effect of a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor on the proliferation rate of retinoblastoma cell lines .
16318954	0	cyclooxygenase-2	21,37	COX-2	39,44	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Protective effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors but not non-selective cyclooxygenase -LRB- COX -RRB- - inhibitors on ethanol withdrawal-induced behavioural changes .
16445867	0	cyclooxygenase-2	58,74	COX-2	76,81	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Reduction in the risk of human breast_cancer by selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16581252	0	cyclooxygenase-2	62,78	COX-2	80,85	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Evaluation of glycolamide_esters of indomethacin as potential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16629370	0	cyclooxygenase-2	10,26	COX-2	28,33	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Effect of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors in various animal models -LRB- bicuculline , picrotoxin , maximal electroshock-induced convulsions -RRB- of epilepsy with possible mechanism of action .
16712734	0	cyclooxygenase-2	27,43	COX-2	45,50	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in patients with surgically resectable adenocarcinoma of the oesophagus .
16806914	0	cyclooxygenase-2	106,122	COX-2	124,129	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
16847764	0	cyclooxygenase-2	25,41	COX-2	43,48	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of cyclooxygenase-2 -LRB- COX-2 -RRB- in multiple_myeloma .
16979925	0	cyclooxygenase-2	38,54	COX-2	56,61	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nuclear_factor-kappaB -LRB- NF-kappaB -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- expression in the oral mucosa following cancer chemotherapy .
17139446	0	cyclooxygenase-2	23,39	COX-2	41,46	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor potentiates the anticonvulsant activity of tiagabine against pentylenetetrazol-induced convulsions in mice .
17147116	0	cyclooxygenase-2	86,102	COX-2	104,109	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Flow cytometric quantitative analysis of multiple_tumor_suppressor_gene_1 -LRB- MTS1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- gene expressions in invasive breast_cancers and their clinical significance -RSB- .
17181139	0	cyclooxygenase-2	16,32	COX-2	34,39	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Scaffold of the cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor carprofen_provides Alzheimer gamma-secretase modulators .
17186551	0	cyclooxygenase-2	36,52	COX-2	54,59	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of UVB-induced and basal cyclooxygenase-2 -LRB- COX-2 -RRB- expression by apigenin in mouse keratinocytes : role of USF transcription factors .
17368333	0	cyclooxygenase-2	12,28	COX-2	30,35	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of cyclooxygenase-2 -LRB- COX-2 -RRB- in inflammatory bone resorption .
17409801	0	cyclooxygenase-2	120,136	COX-2	138,143	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Phase II study of gefitinib , an epidermal growth factor receptor tyrosine kinase inhibitor -LRB- EGFR-TKI -RRB- , and celecoxib , a cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor , in patients with platinum refractory non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
17706175	0	cyclooxygenase-2	59,75	COX-2	77,82	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere .
17729162	0	cyclooxygenase-2	44,60	COX-2	62,67	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Radiosensitization of human glioma cells by cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition : independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration .
17825788	0	cyclooxygenase-2	20,36	COX-2	38,43	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice .
17950526	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human pancreatic_carcinoma cells by the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- system .
17996688	0	cyclooxygenase-2	51,67	COX-2	69,74	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression through the modulation of multiple targets in COX-2 gene promoter .
18042295	0	cyclooxygenase-2	17,33	COX-2	35,40	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The effects of a cyclooxygenase-2 -LRB- COX-2 -RRB- expression and inhibition on human uveal_melanoma cell proliferation and macrophage nitric_oxide production .
18054463	0	cyclooxygenase-2	23,39	COX-2	41,46	cyclooxygenase-2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Rofecoxib , a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor increases pentylenetetrazol seizure threshold in mice : possible involvement of adenosinergic mechanism .
18297687	0	cyclooxygenase-2	97,113	COX-2	115,120	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vitamin_C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- expression and the modulation of insulin-like_growth_factor_II _ -LRB- IGF-II -RRB- production .
18348265	0	cyclooxygenase-2	24,40	COX-2	42,47	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Selective inhibition of cyclooxygenase-2 -LRB- COX-2 -RRB- by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin _ D3 , a less calcemic vitamin_D analog .
18481165	0	cyclooxygenase-2	31,47	COX-2	49,54	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Selective increase of neuronal cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vulnerable brain regions of rats with experimental Wernicke 's _ encephalopathy : effect of nimesulide .
18758643	0	cyclooxygenase-2	38,54	COX-2	56,61	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of the cyclooxygenase-2 -LRB- COX-2 -RRB- in gastric_cancer .
19037084	0	cyclooxygenase-2	10,26	COX-2	28,33	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition reduces proteinuria in renal patients .
19428370	0	cyclooxygenase-2	28,44	COX-2	46,51	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms of cyclooxygenase-2 -LRB- COX-2 -RRB- gene and risk for esophageal_squmaous_cell_carcinoma .
19519538	0	cyclooxygenase-2	10,26	COX-2	28,33	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors used for preventing or regressing cancer .
19523822	0	cyclooxygenase-2	70,86	COX-2	88,93	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
19821125	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in an advanced metastasized hypopharyngeal_carcinoma and cultured_tumor cells .
19836060	0	cyclooxygenase-2	24,40	COX-2	42,47	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic relevance of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in Chinese patients with prostate_cancer .
20489206	0	cyclooxygenase-2	77,93	COX-2	95,100	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Leukotriene_B -LRB- 4 -RRB- BLT receptor signaling regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of Ras/Raf/ERK / p42 AUF1 pathway .
20627335	0	cyclooxygenase-2	28,44	COX-2	46,51	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms of cyclooxygenase-2 -LRB- COX-2 -RRB- gene and risk for urinary bladder_cancer in North India .
20724158	0	cyclooxygenase-2	10,26	COX-2	28,33	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors and breast_cancer risk .
20882760	0	cyclooxygenase-2	23,39	COX-2	41,46	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Effect of preferential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor against 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -LRB- MPTP -RRB- - induced striatal lesions in rats : behavioral , biochemical and histological evidences .
20926918	0	cyclooxygenase-2	76,92	COX-2	94,99	cyclooxygenase-2	COX-2	100009248(Tax:9986)	100009248(Tax:9986)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Endoplasmic reticulum stress -LRB- ER-stress -RRB- by 2-deoxy-D-glucose -LRB- 2DG -RRB- reduces cyclooxygenase-2 -LRB- COX-2 -RRB- expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes .
21198273	0	cyclooxygenase-2	27,43	COX-2	45,50	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Association of the 8473T > C cyclooxygenase-2 -LRB- COX-2 -RRB- gene polymorphism with lung_cancer risk in Asians .
21316237	0	cyclooxygenase-2	81,97	COX-2	99,104	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and evaluation of 1,5-diaryl-substituted _ tetrazoles as novel selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
21612568	0	cyclooxygenase-2	59,75	COX-2	77,82	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Sweet 's _ syndrome associated with the intake of a selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor .
21682897	0	cyclooxygenase-2	133,149	COX-2	151,156	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro : activation of an anti-inflammatory cyclooxygenase-2 -LRB- COX-2 -RRB- pathway .
22016040	0	cyclooxygenase-2	29,45	COX-2	47,52	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Low-level laser irradiation , cyclooxygenase-2 -LRB- COX-2 -RRB- expression and necrosis of random skin flaps in rats .
22341941	0	cyclooxygenase-2	37,53	COX-2	55,60	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel 5-substituted_1H-tetrazoles as cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
22460097	0	cyclooxygenase-2	14,30	COX-2	32,37	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in pituitary_tumours .
22900350	0	cyclooxygenase-2	104,120	COX-2	122,127	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Rationalization of physico-chemical properties of 5 , _ 6-diarylthiazolo _ -LSB- 3,2-b -RSB- -1 , _ 2 , _ 4-triazoles towards cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition : a QSAR approach .
23776069	0	cyclooxygenase-2	60,76	COX-2	83,88	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The -1195 G allele increases the transcriptional activity of cyclooxygenase-2 gene -LRB- COX-2 -RRB- in colon_cancer cell lines .
24878108	0	cyclooxygenase-2	27,43	COX-2	45,50	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Different detectability of cyclooxygenase-2 -LRB- COX-2 -RRB- protein in standard paraffin sections and tissue microarrays of human melanomas and naevi - comparative study .
25196686	0	cyclooxygenase-2	12,28	COX-2	30,35	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Increase in cyclooxygenase-2 -LRB- COX-2 -RRB- expression in keratinocytes and dermal fibroblasts in photoaged skin .
25219899	0	cyclooxygenase-2	121,137	COX-2	139,144	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis , biological evaluation and docking analysis of 3-methyl-1-phenylchromeno -LSB- 4,3-c -RSB- pyrazol-4 -LRB- 1H -RRB- - ones as potential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors .
25242400	0	cyclooxygenase-2	19,35	COX-2	37,42	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- by cannabidiolic_acid in human breast_cancer cells .
25252849	0	cyclooxygenase-2	30,46	COX-2	48,53	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hu-antigen receptor -LRB- HuR -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human non-small-cell_lung_carcinoma : associations with clinicopathological parameters , tumor proliferative capacity and patients ' survival .
25549551	0	cyclooxygenase-2	63,79	COX-2	81,86	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitors : Anti-inflammatory and analgesic activities .
26608958	0	cyclooxygenase-2	34,50	COX-2	52,57	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of cyclooxygenase-2 -LRB- COX-2 -RRB- in oral nevi and melanoma .
8848551	0	cyclooxygenase-2	17,33	COX-2	35,40	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	The induction of cyclooxygenase-2 -LRB- COX-2 -RRB- in intact human amnion tissue by interleukin-4 .
8958057	0	cyclooxygenase-2	19,35	COX-2	37,42	cyclooxygenase-2	COX-2	5743	5743	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- by interleukin-1 receptor antagonist in human monocytes .
9665655	0	cyclooxygenase-2	33,49	COX-2	51,56	cyclooxygenase-2	COX-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Differential effect of selective cyclooxygenase-2 -LRB- COX-2 -RRB- inhibitor NS_398 and diclofenac on formalin-induced nociception in the rat .
21494638	0	cyclooxygenase-2	33,49	COX2	51,55	cyclooxygenase-2	COX2	5743	5743	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Wnt/b-catenin signaling enhances cyclooxygenase-2 -LRB- COX2 -RRB- transcriptional activity in gastric_cancer cells .
18524846	0	cyclooxygenase-2	66,82	CRMP-1	56,62	cyclooxygenase-2	CRMP-1	5743	1400	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Modulation of the expression of the invasion-suppressor CRMP-1 by cyclooxygenase-2 inhibition via reciprocal regulation of Sp1 and C/EBPalpha .
19267906	0	cyclooxygenase-2	78,94	Ciliary_neurotrophic_factor	0,27	cyclooxygenase-2	Ciliary neurotrophic factor	19225(Tax:10090)	12803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- plus soluble CNTF receptor alpha increases cyclooxygenase-2 expression , PGE2 release and interferon-gamma-induced CD40 in murine microglia .
16099597	0	cyclooxygenase-2	37,53	Cox-2	55,60	cyclooxygenase-2	Cox-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nuclear_factor_kappaB -LRB- NFkappaB -RRB- and cyclooxygenase-2 -LRB- Cox-2 -RRB- expression in the irradiated colorectum is associated with subsequent histopathological changes .
16274925	0	cyclooxygenase-2	30,46	Cox-2	48,53	cyclooxygenase-2	Cox-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tissue-specific modulation of cyclooxygenase-2 -LRB- Cox-2 -RRB- expression in the uterus and the v. cava by estrogens and phytoestrogens .
16496341	0	cyclooxygenase-2	65,81	Cox-2	83,88	cyclooxygenase-2	Cox-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 -LRB- Cox-2 -RRB- gene .
16557423	0	cyclooxygenase-2	8,24	Cox-2	26,31	cyclooxygenase-2	Cox-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Imaging cyclooxygenase-2 -LRB- Cox-2 -RRB- gene expression in living animals with a luciferase knock-in reporter gene .
11378164	0	cyclooxygenase-2	21,37	Cyclooxygenase-1	0,16	cyclooxygenase-2	Cyclooxygenase-1	29527(Tax:10116)	24693(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Cyclooxygenase-1 vs. cyclooxygenase-2 inhibitors in the induction of antinociception in rodent withdrawal reflexes .
15893191	0	cyclooxygenase-2	103,119	Cyclooxygenase-1	0,16	cyclooxygenase-2	Cyclooxygenase-1	19225(Tax:10090)	19224(Tax:10090)	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Cyclooxygenase-1 mediates the final stage of morphine-induced delayed cardioprotection in concert with cyclooxygenase-2 .
18242386	0	cyclooxygenase-2	22,38	E-cadherin	74,84	cyclooxygenase-2	E-cadherin	5743	999	Gene	Gene	inhibitor|amod|START_ENTITY Etodolac|appos|inhibitor induces|nsubj|Etodolac induces|dobj|upregulation upregulation|nmod|END_ENTITY	Etodolac , a selective cyclooxygenase-2 inhibitor , induces upregulation of E-cadherin and has antitumor effect on human bladder_cancer cells in vitro and in vivo .
19622294	0	cyclooxygenase-2	61,77	E-cadherin	92,102	cyclooxygenase-2	E-cadherin	5743	999	Gene	Gene	inhibitor|amod|START_ENTITY celecoxib|appos|inhibitor celecoxib|nmod|expression expression|amod|END_ENTITY	-LSB- Short-term preoperative treatment of celecoxib , a selective cyclooxygenase-2 inhibitor , on E-cadherin expression in gastric_carcinoma tissues -RSB- .
16840721	0	cyclooxygenase-2	19,35	Endoglin	0,8	cyclooxygenase-2	Endoglin	19225(Tax:10090)	13805(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Endoglin regulates cyclooxygenase-2 expression and activity .
11423565	0	cyclooxygenase-2	21,37	Endothelin-1	0,12	cyclooxygenase-2	Endothelin-1	29527(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells .
15838264	0	cyclooxygenase-2	24,40	Endothelin-1	0,12	cyclooxygenase-2	Endothelin-1	5743	1906	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian_cancer cells through multiple signaling pathways : evidence for involvement of transactivation of the epidermal_growth_factor_receptor .
15838313	0	cyclooxygenase-2	21,37	Endothelin-1	0,12	cyclooxygenase-2	Endothelin-1	29527(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Endothelin-1 induces cyclooxygenase-2 expression and generation of reactive oxygen species in endothelial cells .
18191873	0	cyclooxygenase-2	37,53	Endothelin-1	0,12	cyclooxygenase-2	Endothelin-1	5743	1906	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells .
20452970	0	cyclooxygenase-2	171,187	Endothelin-1	0,12	cyclooxygenase-2	Endothelin-1	5743	1906	Gene	Gene	A|dep|START_ENTITY role|nmod|A prostacyclin|nsubj|role increases|parataxis|prostacyclin increases|nsubj|END_ENTITY	Endothelin-1 -LRB- ET-1 -RRB- increases the expression of remodeling genes in vascular smooth muscle through linked calcium and cAMP pathways : role of a phospholipase A -LRB- 2 -RRB- -LRB- cPLA -LRB- 2 -RRB- -RRB- / cyclooxygenase-2 -LRB- COX-2 -RRB- / prostacyclin receptor-dependent autocrine loop .
7731170	0	cyclooxygenase-2	26,42	Endothelin-1	0,12	cyclooxygenase-2	Endothelin-1	29527(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells .
9012840	0	cyclooxygenase-2	73,89	Epidermal_growth_factor_receptor	0,32	cyclooxygenase-2	Epidermal growth factor receptor	5743	1956	Gene	Gene	release|amod|START_ENTITY nuclear|nmod|release induces|dobj|nuclear induces|nsubj|activation activation|compound|END_ENTITY	Epidermal_growth_factor_receptor activation induces nuclear targeting of cyclooxygenase-2 , basolateral release of prostaglandins , and mitogenesis in polarizing colon_cancer cells .
20585313	0	cyclooxygenase-2	15,31	ErbB4	0,5	cyclooxygenase-2	ErbB4	19225(Tax:10090)	13869(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells .
12239223	0	cyclooxygenase-2	19,35	Gastrin	0,7	cyclooxygenase-2	Gastrin	29527(Tax:10116)	25320(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways .
12388195	0	cyclooxygenase-2	51,67	Gastrin	0,7	cyclooxygenase-2	Gastrin	29527(Tax:10116)	25320(Tax:10116)	Gene	Gene	upregulation|amod|START_ENTITY enhances|nmod|upregulation enhances|nsubj|END_ENTITY	Gastrin enhances gastric mucosal integrity through cyclooxygenase-2 upregulation in rats .
12891702	0	cyclooxygenase-2	39,55	Gastrin	0,7	cyclooxygenase-2	Gastrin	19225(Tax:10090)	14459(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Gastrin and EGF synergistically induce cyclooxygenase-2 expression in Swiss_3T3 fibroblasts that express the CCK2 receptor .
15655524	0	cyclooxygenase-2	76,92	Gastrin	0,7	cyclooxygenase-2	Gastrin	5743	2520	Gene	Gene	induction|amod|START_ENTITY growth|nmod|induction promotes|dobj|growth promotes|nsubj|END_ENTITY	Gastrin promotes human colon_cancer cell growth via CCK-2_receptor-mediated cyclooxygenase-2 induction and prostaglandin_E2 production .
23376640	0	cyclooxygenase-2	56,72	Gastrin	0,7	cyclooxygenase-2	Gastrin	5743	2520	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Gastrin acting on the cholecystokinin2_receptor induces cyclooxygenase-2 expression through JAK2/STAT3/PI3K / Akt pathway in human gastric_cancer cells .
23000033	0	cyclooxygenase-2	51,67	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	cyclooxygenase-2	Glyceraldehyde-3-phosphate dehydrogenase	19225(Tax:10090)	14433(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability .
15001457	0	cyclooxygenase-2	13,29	HDL3	0,4	cyclooxygenase-2	HDL3	5743	53369	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway : effects on COX-2 / PGI-synthase coupling .
14985703	0	cyclooxygenase-2	43,59	HER-2	14,19	cyclooxygenase-2	HER-2	5743	2064	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin_E2 .
16416603	0	cyclooxygenase-2	51,67	HER3	28,32	cyclooxygenase-2	HER3	5743	2065	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon_cancer cells .
20470258	0	cyclooxygenase-2	81,97	Heme_oxygenase-1	0,16	cyclooxygenase-2	Heme oxygenase-1	5743	3162	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Heme_oxygenase-1 mediates nicotine - and lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in human periodontal ligament cells .
11197751	0	cyclooxygenase-2	115,131	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	Hepatocyte growth factor	5743	3082	Gene	Gene	induction|nmod|START_ENTITY protects|nmod|induction protects|nsubj|END_ENTITY	Hepatocyte_growth_factor protects gastric epithelial cells against ceramide-induced apoptosis through induction of cyclooxygenase-2 .
12393863	0	cyclooxygenase-2	88,104	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	Hepatocyte growth factor	5743	3082	Gene	Gene	induction|nmod|START_ENTITY inhibits|nmod|induction inhibits|nsubj|END_ENTITY	Hepatocyte_growth_factor inhibits anoikis by induction of activator_protein_1-dependent cyclooxygenase-2 .
16139560	0	cyclooxygenase-2	52,68	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	Hepatocyte growth factor	5743	3082	Gene	Gene	pathway|amod|START_ENTITY correlates|nmod|pathway correlates|nsubj|expression expression|amod|END_ENTITY	Hepatocyte_growth_factor expression correlates with cyclooxygenase-2 pathway in human salivary_gland_tumors .
18097584	0	cyclooxygenase-2	72,88	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	Hepatocyte growth factor	5743	3082	Gene	Gene	expression|amod|START_ENTITY up-regulation|nmod|expression induces|nmod|up-regulation induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces anoikis resistance by up-regulation of cyclooxygenase-2 expression in uterine endometrial_cancer cells .
18245266	0	cyclooxygenase-2	35,51	Hepatocyte_growth_factor	0,24	cyclooxygenase-2	Hepatocyte growth factor	5743	3082	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor regulates cyclooxygenase-2 expression via beta-catenin , Akt , and p42/p44 _ MAPK in human bronchial epithelial cells .
11733561	0	cyclooxygenase-2	61,77	HuR	48,51	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|expression expression|nmod|END_ENTITY	Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon_cancer cells .
12704185	0	cyclooxygenase-2	56,72	HuR	24,27	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The RNA-binding protein HuR regulates the expression of cyclooxygenase-2 .
12855701	0	cyclooxygenase-2	53,69	HuR	127,130	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	region|nmod|START_ENTITY recognized|nsubjpass|region recognized|nmod|complex complex|acl|containing containing|dobj|TIAR TIAR|compound|END_ENTITY	The proximal region of the 3 ' - untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR , TIA-1 , TIAR , and the heterogeneous_nuclear_ribonucleoprotein_U .
17208222	0	cyclooxygenase-2	25,41	HuR	127,130	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	mRNA|amod|START_ENTITY destabilizes|dobj|mRNA destabilizes|advcl|inhibiting inhibiting|dobj|shuttling shuttling|nmod|END_ENTITY	Thalidomide destabilizes cyclooxygenase-2 mRNA by inhibiting p38_mitogen-activated_protein_kinase and cytoplasmic shuttling of HuR .
17392515	0	cyclooxygenase-2	136,152	HuR	80,83	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	regulation|nmod|START_ENTITY implications|nmod|regulation phosphorylation|dep|implications phosphorylation|nmod|END_ENTITY	Protein_kinase_C_alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR : implications for posttranscriptional regulation of cyclooxygenase-2 .
17448140	0	cyclooxygenase-2	18,34	HuR	63,66	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	correlates|amod|START_ENTITY Overexpression|nmod|correlates Overexpression|nmod|expression expression|compound|END_ENTITY	Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary_mucoepidermoid_carcinoma but not in pleomorphic_adenoma .
17581403	0	cyclooxygenase-2	47,63	HuR	14,17	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical_carcinoma .
18027256	0	cyclooxygenase-2	61,77	HuR	12,15	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|over-expression over-expression|compound|END_ENTITY	Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal_squamous_cell_carcinomas .
18831511	0	cyclooxygenase-2	108,124	HuR	64,67	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	association|nmod|START_ENTITY Expression|dep|association Expression|nmod|END_ENTITY	Expression of the embryonic_lethal_abnormal_vision-like protein HuR in human mesothelioma : association with cyclooxygenase-2 and prognosis .
19707506	0	cyclooxygenase-2	44,60	HuR	26,29	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	expression|amod|START_ENTITY related|nmod|expression related|nsubjpass|expression expression|nmod|END_ENTITY	Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon_cancer .
21391979	0	cyclooxygenase-2	14,30	HuR	132,135	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of cyclooxygenase-2 and cytosolic phospholipase A2 gene expression by lipopolysaccharide through the RNA-binding protein HuR : involvement of NADPH oxidase , reactive oxygen species and mitogen-activated protein kinases .
21572400	0	cyclooxygenase-2	83,99	HuR	14,17	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	stabilizes|xcomp|START_ENTITY stabilizes|nsubj|Expression Expression|nmod|END_ENTITY	Expression of HuR , COX-2 , and survivin in lung_cancers ; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous_cell_carcinomas .
21572400	0	cyclooxygenase-2	83,99	HuR	68,71	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	stabilizes|xcomp|START_ENTITY stabilizes|nsubj|Expression Expression|nmod|HuR HuR|dep|END_ENTITY	Expression of HuR , COX-2 , and survivin in lung_cancers ; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous_cell_carcinomas .
23355539	0	cyclooxygenase-2	19,35	HuR	84,87	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	expression|amod|START_ENTITY expression|parataxis|enhances enhances|nsubj|interaction interaction|compound|END_ENTITY	Lapatinib-mediated cyclooxygenase-2 expression via epidermal_growth_factor_receptor / HuR interaction enhances the aggressiveness of triple-negative breast_cancer cells .
24086407	0	cyclooxygenase-2	96,112	HuR	57,60	cyclooxygenase-2	HuR	5743	1994	Gene	Gene	independent|amod|START_ENTITY suppresses|dobj|independent suppresses|nsubj|retention retention|nmod|END_ENTITY	Aryl_hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding .
15728492	0	cyclooxygenase-2	68,84	IFN-gamma	99,108	cyclooxygenase-2	IFN-gamma	19225(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Involvement of TNF and NF-kappa_B in the transcriptional control of cyclooxygenase-2 expression by IFN-gamma in macrophages .
9725242	0	cyclooxygenase-2	20,36	IFN-gamma	83,92	cyclooxygenase-2	IFN-gamma	5743	3458	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Novel regulation of cyclooxygenase-2 expression and prostaglandin_E2 production by IFN-gamma in human macrophages .
17016440	0	cyclooxygenase-2	32,48	IFNgamma	63,71	cyclooxygenase-2	IFNgamma	5743	3458	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	STAT1-independent inhibition of cyclooxygenase-2 expression by IFNgamma ; a common pathway of IFNgamma-mediated gene repression but not gene activation .
15219461	0	cyclooxygenase-2	35,51	IL-10	99,104	cyclooxygenase-2	IL-10	5743	3586	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of IL-6 , TNF-alpha , and cyclooxygenase-2 protein expression by prostaglandin_E2-induced IL-10 in bone marrow-derived dendritic cells .
10810453	0	cyclooxygenase-2	27,43	IL-1_beta	90,99	cyclooxygenase-2	IL-1 beta	5743	3553	Gene	Gene	stability|amod|START_ENTITY stability|nmod|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
21885043	0	cyclooxygenase-2	18,34	IL-1b	51,56	cyclooxygenase-2	IL-1b	29527(Tax:10116)	24494(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The gene encoding cyclooxygenase-2 is regulated by IL-1b and prostaglandins in 832/13 rat insulinoma cells .
22878602	0	cyclooxygenase-2	43,59	IL-1b	119,124	cyclooxygenase-2	IL-1b	5743	3553	Gene	Gene	inhibitor|amod|START_ENTITY exposed|nsubj|inhibitor exposed|nmod|END_ENTITY	In vitro effects of VA441 , a new selective cyclooxygenase-2 inhibitor , on human osteoarthritic chondrocytes exposed to IL-1b .
12537697	0	cyclooxygenase-2	79,95	IRF-1	47,52	cyclooxygenase-2	IRF-1	19225(Tax:10090)	16362(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|amod|END_ENTITY	The role of the interferon regulatory factors , IRF-1 and IRF-2 , in LPS-induced cyclooxygenase-2 -LRB- COX-2 -RRB- expression in vivo and in vitro .
11160331	0	cyclooxygenase-2	32,48	Il-10	0,5	cyclooxygenase-2	Il-10	19225(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Il-10 is a central regulator of cyclooxygenase-2 expression and prostaglandin production .
16818793	0	cyclooxygenase-2	24,40	Interleukin-13	0,14	cyclooxygenase-2	Interleukin-13	29527(Tax:10116)	116553(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia : implications for death of activated microglia .
10533051	0	cyclooxygenase-2	194,210	Interleukin-1_beta	0,18	cyclooxygenase-2	Interleukin-1 beta	29527(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mediator|nmod|expression platelet-activating_factor|nmod|mediator expression|dep|platelet-activating_factor expression|amod|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
10533051	0	cyclooxygenase-2	43,59	Interleukin-1_beta	0,18	cyclooxygenase-2	Interleukin-1 beta	29527(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
21683339	0	cyclooxygenase-2	27,43	Interleukin-1_beta	0,18	cyclooxygenase-2	Interleukin-1 beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY affects|dobj|expression affects|nsubj|END_ENTITY	Interleukin-1_beta affects cyclooxygenase-2 expression and cartilage metabolism in mandibular condyle .
8526991	0	cyclooxygenase-2	27,43	Interleukin-1_beta	0,18	cyclooxygenase-2	Interleukin-1 beta	5743	3553	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1_beta induces cyclooxygenase-2 in cultured human decidual cells .
8543370	0	cyclooxygenase-2	41,57	Interleukin-1_beta	0,18	cyclooxygenase-2	Interleukin-1 beta	5743	3553	Gene	Gene	mRNA|amod|START_ENTITY expression|nmod|mRNA induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_beta induces expression of cyclooxygenase-2 mRNA in human gingival fibroblasts .
8632179	0	cyclooxygenase-2	57,73	Interleukin-1_beta	0,18	cyclooxygenase-2	Interleukin-1 beta	19225(Tax:10090)	16176(Tax:10090)	Gene	Gene	H|dep|START_ENTITY prostaglandin_G|dobj|H induces|xcomp|prostaglandin_G induces|nsubj|END_ENTITY	Interleukin-1_beta induces prostaglandin_G / H synthase-2 -LRB- cyclooxygenase-2 -RRB- in primary murine astrocyte cultures .
9467571	0	cyclooxygenase-2	27,43	Interleukin-1_beta	0,18	cyclooxygenase-2	Interleukin-1 beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_beta induces cyclooxygenase-2 gene expression in cultured endometrial stromal cells .
21762900	0	cyclooxygenase-2	23,39	Interleukin-1b	0,14	cyclooxygenase-2	Interleukin-1b	5743	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1b induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian_endometrioma .
10537081	0	cyclooxygenase-2	88,104	Interleukin-1beta	0,17	cyclooxygenase-2	Interleukin-1beta	29527(Tax:10116)	24494(Tax:10116)	Gene	Gene	system|amod|START_ENTITY induces|nmod|system induces|nsubj|END_ENTITY	Interleukin-1beta induces substance P release from primary afferent neurons through the cyclooxygenase-2 system .
11032891	0	cyclooxygenase-2	26,42	Interleukin-1beta	0,17	cyclooxygenase-2	Interleukin-1beta	5743	3553	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1beta induces cyclooxygenase-2 and prostaglandin_E -LRB- 2 -RRB- synthesis in human neuroblastoma cells : involvement of p38_mitogen-activated_protein_kinase and nuclear factor-kappaB .
12107235	0	cyclooxygenase-2	27,43	Interleukin-1beta	0,17	cyclooxygenase-2	Interleukin-1beta	5743	3553	Gene	Gene	level|amod|START_ENTITY elevates|dobj|level elevates|nsubj|END_ENTITY	Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells : an effect mediated by extracellularly regulated kinases 1 and 2 .
12391274	0	cyclooxygenase-2	60,76	Interleukin-1beta	0,17	cyclooxygenase-2	Interleukin-1beta	5743	3553	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells .
14670842	0	cyclooxygenase-2	208,224	Interleukin-1beta	0,17	cyclooxygenase-2	Interleukin-1beta	5743	3553	Gene	Gene	induction|amod|START_ENTITY prostacyclin|nmod|induction smooth|advcl|prostacyclin smooth|nsubj|production production|amod|attenuate attenuate|dep|END_ENTITY	Interleukin-1beta , transforming_growth_factor-beta1 , and bradykinin attenuate cyclic_AMP production by human pulmonary artery smooth muscle cells in response to prostacyclin analogues and prostaglandin_E2 by cyclooxygenase-2 induction and downregulation of adenylyl cyclase isoforms 1 , 2 , and 4 .
19393083	0	cyclooxygenase-2	78,94	Interleukin-1beta	0,17	cyclooxygenase-2	Interleukin-1beta	5743	3553	Gene	Gene	induce|xcomp|START_ENTITY cooperate|xcomp|induce cooperate|nsubj|END_ENTITY	Interleukin-1beta and fibroblast_growth_factor_receptor_1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis .
17074047	0	cyclooxygenase-2	15,31	Leptin	0,6	cyclooxygenase-2	Leptin	29527(Tax:10116)	25608(Tax:10116)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain .
19154413	0	cyclooxygenase-2	40,56	Leptin	0,6	cyclooxygenase-2	Leptin	5743	3952	Gene	Gene	pathways|amod|START_ENTITY activation|nmod|pathways induces|dobj|activation induces|nsubj|END_ENTITY	Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3 , MAPK/ERK , and PI3K/AKT pathways in human endometrial_cancer cells .
12138126	0	cyclooxygenase-2	40,56	MDR-1	14,19	cyclooxygenase-2	MDR-1	29527(Tax:10116)	24646(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MDR-1 -LRB- P-glycoprotein -RRB- by cyclooxygenase-2 .
17303970	0	cyclooxygenase-2	11,27	MK-0703	0,7	cyclooxygenase-2	MK-0703	5743	1476804(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	MK-0703 -LRB- a cyclooxygenase-2 inhibitor -RRB- in acute pain associated with dental surgery : a randomized , double-blind , placebo - and active comparator-controlled dose-ranging study .
24552656	0	cyclooxygenase-2	52,68	MKP-1	84,89	cyclooxygenase-2	MKP-1	19225(Tax:10090)	19252(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Valproic_acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells .
15934011	0	cyclooxygenase-2	89,105	NAC	21,24	cyclooxygenase-2	NAC	5743	7504	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells .
10454683	0	cyclooxygenase-2	92,108	NF-kappaB	33,42	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	The nuclear transcription factor NF-kappaB mediates interleukin-1beta-induced expression of cyclooxygenase-2 in human myometrial cells .
11162356	0	cyclooxygenase-2	58,74	NF-kappaB	9,18	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	expression|amod|START_ENTITY prohibits|dobj|expression prohibits|nsubj|activation activation|amod|END_ENTITY	Blockade NF-kappaB activation prohibits TNF-alpha-induced cyclooxygenase-2 gene expression in ED27 trophoblast-like cells .
11853875	0	cyclooxygenase-2	67,83	NF-kappaB	19,28	cyclooxygenase-2	NF-kappaB	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY involvement|nmod|overexpression involvement|nmod|END_ENTITY	The involvement of NF-kappaB in the constitutive overexpression of cyclooxygenase-2 in cyclooxygenase-1 null cells .
12349896	0	cyclooxygenase-2	31,47	NF-kappaB	99,108	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	expression|amod|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|cells cells|amod|amentoflavone amentoflavone|nmod|suppression suppression|nmod|activation activation|amod|END_ENTITY	Inhibition of TNFalpha-induced cyclooxygenase-2 expression by amentoflavone through suppression of NF-kappaB activation in A549 cells .
12485900	0	cyclooxygenase-2	72,88	NF-kappaB	107,116	cyclooxygenase-2	NF-kappaB	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of selected ginsenosides on phorbol_ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin .
12860389	0	cyclooxygenase-2	87,103	NF-kappaB	33,42	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	synthase|amod|START_ENTITY expression|nmod|synthase release|nmod|expression mediates|dobj|release mediates|nsubj|activation activation|nmod|END_ENTITY	IL-1beta-dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin_E synthase .
14630924	0	cyclooxygenase-2	190,206	NF-kappaB	22,31	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	abrogation|nmod|START_ENTITY activation|dep|abrogation activation|amod|END_ENTITY	Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation : abrogation of cyclin_D1 , cyclooxygenase-2 , and matrix metalloprotease-9 .
14633657	0	cyclooxygenase-2	35,51	NF-kappaB	88,97	cyclooxygenase-2	NF-kappaB	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Nitric_oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB .
15020231	0	cyclooxygenase-2	13,29	NF-kappaB	66,75	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|role role|nmod|END_ENTITY	Induction of cyclooxygenase-2 in macrophages by catalase : role of NF-kappaB and PI3K signaling pathways .
15655349	0	cyclooxygenase-2	27,43	NF-kappaB	95,104	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|nuclear_factor-kappa_B nuclear_factor-kappa_B|appos|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
16336399	0	cyclooxygenase-2	118,134	NF-kappaB	83,92	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Aspirin induces apoptosis in oesophageal_cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2 .
17403674	0	cyclooxygenase-2	43,59	NF-kappaB	89,98	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	NADPH oxidase NOX5-S mediates acid-induced cyclooxygenase-2 expression via activation of NF-kappaB in Barrett 's esophageal_adenocarcinoma cells .
19160097	0	cyclooxygenase-2	115,131	NF-kappaB	80,89	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	NS-398 induces apoptosis in human esophageal_cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2 .
19618291	0	cyclooxygenase-2	61,77	NF-kappaB	96,105	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Toll-like_receptor_9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate_cancer cells .
22803374	0	cyclooxygenase-2	70,86	NF-kappaB	11,20	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	Effect|amod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of NF-kappaB on inhibition of non-small_cell_lung_cancer cell cyclooxygenase-2 by brucine -RSB- .
8995303	0	cyclooxygenase-2	16,32	NF-kappaB	41,50	cyclooxygenase-2	NF-kappaB	5743	4790	Gene	Gene	START_ENTITY|nmod|factor factor|amod|END_ENTITY	Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells .
9414121	0	cyclooxygenase-2	46,62	NF-kappaB	15,24	cyclooxygenase-2	NF-kappaB	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression Involvement|nmod|regulation Involvement|nmod|END_ENTITY	Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages .
10453032	0	cyclooxygenase-2	91,107	NF-kappa_B	46,56	cyclooxygenase-2	NF-kappa B	5743	4790	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression activation|acl:relcl|promotes activation|amod|END_ENTITY	Superoxide attenuates macrophage apoptosis by NF-kappa_B and AP-1 activation that promotes cyclooxygenase-2 expression .
12230110	0	cyclooxygenase-2	14,30	NF-kappa_B	146,156	cyclooxygenase-2	NF-kappa B	5743	4790	Gene	Gene	cytokines|amod|START_ENTITY Expression|nmod|cytokines requires|nsubj|Expression requires|dobj|activation activation|amod|END_ENTITY	Expression of cyclooxygenase-2 and pro-inflammatory cytokines induced by 2,2 ' ,4,4 ' ,5,5 ' - hexachlorobiphenyl -LRB- PCB_153 -RRB- in human mast cells requires NF-kappa_B activation .
12646188	0	cyclooxygenase-2	98,114	NF-kappa_B	62,72	cyclooxygenase-2	NF-kappa B	5743	4790	Gene	Gene	expression|amod|START_ENTITY mediates|dobj|expression activation|acl:relcl|mediates activation|amod|END_ENTITY	Protein_kinase_C_alpha and zeta regulate nitric_oxide-induced NF-kappa_B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes .
19734210	0	cyclooxygenase-2	70,86	NF-kappa_B	44,54	cyclooxygenase-2	NF-kappa B	5743	4790	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	P2Y2 receptor transcription is increased by NF-kappa_B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells .
21104307	0	cyclooxygenase-2	38,54	NF-kappa_B	109,119	cyclooxygenase-2	NF-kappa B	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY activation|nmod|gene sites|nsubj|activation sites|amod|dependent dependent|nmod|END_ENTITY	The transcriptional activation of the cyclooxygenase-2 gene in zymosan-activated macrophages is dependent on NF-kappa_B , C/EBP , AP-1 , and CRE sites .
12349897	0	cyclooxygenase-2	106,122	NFkappaB	149,157	cyclooxygenase-2	NFkappaB	5743	4790	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Tumor_necrosis factor alpha -LRB- TNF-alpha -RRB- - induced prostaglandin_E2 release is mediated by the activation of cyclooxygenase-2 -LRB- COX-2 -RRB- transcription via NFkappaB in human_gingival_fibroblasts .
11310828	0	cyclooxygenase-2	32,48	Nuclear_factor-kappaB	0,21	cyclooxygenase-2	Nuclear factor-kappaB	5743	4790	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nuclear_factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric_cancer cells .
15112579	0	cyclooxygenase-2	33,49	Nuclear_factor-kappa_B	0,22	cyclooxygenase-2	Nuclear factor-kappa B	5743	4790	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nuclear_factor-kappa_B regulates cyclooxygenase-2 expression and cell proliferation in human colorectal_carcinoma tissue .
12138126	0	cyclooxygenase-2	40,56	P-glycoprotein	21,35	cyclooxygenase-2	P-glycoprotein	29527(Tax:10116)	287115(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of MDR-1 -LRB- P-glycoprotein -RRB- by cyclooxygenase-2 .
17341442	0	cyclooxygenase-2	37,53	PI3K	69,73	cyclooxygenase-2	PI3K	5743	5293	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Insulin-like_growth_factor-I induces cyclooxygenase-2 expression via PI3K , MAPK and PKC signaling pathways in human ovarian_cancer cells .
12920574	0	cyclooxygenase-2	51,67	PTGS2	74,79	cyclooxygenase-2	PTGS2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a promoter variant in the inducible cyclooxygenase-2 gene -LRB- PTGS2 -RRB- with type_2_diabetes_mellitus in Pima Indians .
16489098	0	cyclooxygenase-2	4,20	PTGS2	22,27	cyclooxygenase-2	PTGS2	5743	5743	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	The cyclooxygenase-2 -LRB- PTGS2 -RRB- 8473T > C polymorphism is associated with breast_cancer risk .
19821778	0	cyclooxygenase-2	33,49	Parathyroid_hormone	0,19	cyclooxygenase-2	Parathyroid hormone	19225(Tax:10090)	19226(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Parathyroid_hormone induction of cyclooxygenase-2 in murine osteoblasts : role of the calcium-calcineurin-NFAT pathway .
18648741	0	cyclooxygenase-2	59,75	Peroxisome_proliferator-activated_receptor_alpha	0,48	cyclooxygenase-2	Peroxisome proliferator-activated receptor alpha	5743	5465	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha activates cyclooxygenase-2 gene transcription through bile_acid transport in human colorectal_cancer cell lines .
23254481	0	cyclooxygenase-2	55,71	Platelet-derived_growth_factor-D	0,32	cyclooxygenase-2	Platelet-derived growth factor-D	29527(Tax:10116)	66018(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Platelet-derived_growth_factor-D induces expression of cyclooxygenase-2 in rat mesangial cells through activation of PI3K/PKB and PKCs .
20740367	0	cyclooxygenase-2	40,56	Protease-activated_receptor-2	0,29	cyclooxygenase-2	Protease-activated receptor-2	5743	2150	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Protease-activated_receptor-2 regulates cyclooxygenase-2 expression in human bile_duct_cancer via the pathways of mitogen-activated protein kinases and nuclear factor kappa B. BACKGROUND/PURPOSE : Recent studies have suggested that protease-activated_receptor-2 -LRB- PAR-2 -RRB- activity correlates with cell proliferation and tumor growth , and its activation induces expression of cyclooxygenase-2 -LRB- COX-2 -RRB- .
17962194	0	cyclooxygenase-2	40,56	Proteinase-activated_receptor-2	0,31	cyclooxygenase-2	Proteinase-activated receptor-2	5743	2150	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Proteinase-activated_receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic_AMP-response element-binding protein .
17575012	0	cyclooxygenase-2	14,30	Rac2	58,62	cyclooxygenase-2	Rac2	19225(Tax:10090)	19354(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages .
16585602	0	cyclooxygenase-2	23,39	Substance_P	0,11	cyclooxygenase-2	Substance P	5743	6863	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Substance_P stimulates cyclooxygenase-2 and prostaglandin_E2 expression through JAK-STAT activation in human colonic epithelial cells .
20926798	0	cyclooxygenase-2	24,40	Substance_P	0,11	cyclooxygenase-2	Substance P	19225(Tax:10090)	21333(Tax:10090)	Gene	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	Substance_P upregulates cyclooxygenase-2 and prostaglandin_E metabolite by activating ERK1/2 and NF-kappaB in a mouse model of burn-induced remote acute_lung_injury .
12855701	0	cyclooxygenase-2	53,69	TIA-1	132,137	cyclooxygenase-2	TIA-1	5743	7072	Gene	Gene	region|nmod|START_ENTITY recognized|nsubjpass|region recognized|nmod|complex complex|acl|containing containing|dobj|TIAR TIAR|appos|END_ENTITY	The proximal region of the 3 ' - untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR , TIA-1 , TIAR , and the heterogeneous_nuclear_ribonucleoprotein_U .
12885872	0	cyclooxygenase-2	14,30	TIA-1	72,77	cyclooxygenase-2	TIA-1	5743	7072	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1 .
19616539	0	cyclooxygenase-2	17,33	Thrombin	0,8	cyclooxygenase-2	Thrombin	5743	2147	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces cyclooxygenase-2 expression via the ERK and NF-kappaB pathways in human lung fibroblasts .
19739103	0	cyclooxygenase-2	17,33	Thrombin	0,8	cyclooxygenase-2	Thrombin	19225(Tax:10090)	14061(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces cyclooxygenase-2 expression and prostaglandin_E2 release via PAR1 activation and ERK1/2 - and p38_MAPK-dependent pathway in murine macrophages .
10692471	0	cyclooxygenase-2	71,87	Transforming_growth_factor-beta1	0,32	cyclooxygenase-2	Transforming growth factor-beta1	5743	7040	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Transforming_growth_factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA .
11356928	0	cyclooxygenase-2	36,52	Tumor_necrosis_factor-alpha	0,27	cyclooxygenase-2	Tumor necrosis factor-alpha	282023(Tax:9913)	280943(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces cyclooxygenase-2 expression and prostaglandin release in brain microvessel endothelial cells .
22800939	0	cyclooxygenase-2	42,58	Tumor_necrosis_factor-alpha	0,27	cyclooxygenase-2	Tumor necrosis factor-alpha	19225(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces renal cyclooxygenase-2 expression in response to hypercalcemia .
9440135	0	cyclooxygenase-2	47,63	Tumor_necrosis_factor-alpha	0,27	cyclooxygenase-2	Tumor necrosis factor-alpha	5743	7124	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha promotes sustained cyclooxygenase-2 expression : attenuation by dexamethasone and NSAIDs .
19318580	0	cyclooxygenase-2	104,120	US28	53,57	cyclooxygenase-2	US28	5743	3077536(Tax:10359)	Gene	Gene	angiogenesis|nmod|START_ENTITY promotes|dobj|angiogenesis promotes|nsubj|END_ENTITY	The human_cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2 .
12107271	0	cyclooxygenase-2	48,64	Vascular_endothelial_growth_factor	0,34	cyclooxygenase-2	Vascular endothelial growth factor	5743	7422	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor up-regulates cyclooxygenase-2 expression in human endothelial cells .
21867538	0	cyclooxygenase-2	125,141	Vascular_endothelial_growth_factor	0,34	cyclooxygenase-2	Vascular endothelial growth factor	5743	7422	Gene	Gene	microenvironment|nmod|START_ENTITY adhesion|nmod|microenvironment regulates|dobj|adhesion regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2 .
10884377	0	cyclooxygenase-2	14,30	Wnt-3	48,53	cyclooxygenase-2	Wnt-3	5743	7473	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cyclooxygenase-2 and periostin by Wnt-3 in mouse mammary epithelial cells .
15528468	0	cyclooxygenase-2	54,70	Xanthine_oxidoreductase	0,23	cyclooxygenase-2	Xanthine oxidoreductase	19225(Tax:10090)	22436(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Xanthine_oxidoreductase is an endogenous regulator of cyclooxygenase-2 .
17363560	0	cyclooxygenase-2	54,70	activator_protein_1	18,37	cyclooxygenase-2	activator protein 1	19225(Tax:10090)	16476(Tax:10090)	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	Dominant-negative activator_protein_1 -LRB- TAM67 -RRB- targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis .
14691168	0	cyclooxygenase-2	60,76	alpha-melanocyte-stimulating_hormone	99,135	cyclooxygenase-2	alpha-melanocyte-stimulating hormone	29527(Tax:10116)	24664(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of endotoxin-induced uveitis and potentiation of cyclooxygenase-2 protein expression by alpha-melanocyte-stimulating_hormone .
18827978	0	cyclooxygenase-2	29,45	angiotensin_II	69,83	cyclooxygenase-2	angiotensin II	5743	183	Gene	Gene	induction|nmod|START_ENTITY fibroblasts|nsubj|induction fibroblasts|nmod|END_ENTITY	The synergistic induction of cyclooxygenase-2 in lung fibroblasts by angiotensin_II and pro-inflammatory cytokines .
20668099	0	cyclooxygenase-2	10,26	angiotensin_II	78,92	cyclooxygenase-2	angiotensin II	29527(Tax:10116)	24179(Tax:10116)	Gene	Gene	effects|amod|START_ENTITY Augmented|dobj|effects Augmented|nmod|states states|nmod|END_ENTITY	Augmented cyclooxygenase-2 effects on renal function during varying states of angiotensin_II .
21734188	0	cyclooxygenase-2	33,49	apolipoprotein_A-I	6,24	cyclooxygenase-2	apolipoprotein A-I	5743	335	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Human apolipoprotein_A-I induces cyclooxygenase-2 expression and prostaglandin_I-2 release in endothelial cells through ATP-binding_cassette_transporter_A1 .
19074839	0	cyclooxygenase-2	40,56	b2_receptor	6,17	cyclooxygenase-2	b2 receptor	5743	624	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Kinin b2_receptor mediates induction of cyclooxygenase-2 and is overexpressed in head_and_neck_squamous_cell_carcinomas .
18245266	0	cyclooxygenase-2	35,51	beta-catenin	67,79	cyclooxygenase-2	beta-catenin	5743	1499	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Hepatocyte_growth_factor regulates cyclooxygenase-2 expression via beta-catenin , Akt , and p42/p44 _ MAPK in human bronchial epithelial cells .
18751438	0	cyclooxygenase-2	30,46	beta-catenin	56,68	cyclooxygenase-2	beta-catenin	5743	1499	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Microvessel density -LRB- MVD -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- / beta-catenin interaction are associated with relapse in patients with transitional carcinoma receiving adjuvant chemotherapy with paclitaxel/carboplatin : a hellenic cooperative oncology group -LRB- HECOG -RRB- study .
21679035	0	cyclooxygenase-2	132,148	beta-catenin	163,175	cyclooxygenase-2	beta-catenin	19225(Tax:10090)	12387(Tax:10090)	Gene	Gene	localisation|amod|START_ENTITY localisation|amod|END_ENTITY	Reduced tumour progression and angiogenesis in 1,2-dimethylhydrazine mice treated with NS-398 is associated with down-regulation of cyclooxygenase-2 and decreased beta-catenin nuclear localisation .
9987081	0	cyclooxygenase-2	13,29	beta_2-microglobulin	57,77	cyclooxygenase-2	beta 2-microglobulin	5743	567	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 in human synovial cells by beta_2-microglobulin .
9435567	0	cyclooxygenase-2	79,95	bradykinin	16,26	cyclooxygenase-2	bradykinin	5743	3827	Gene	Gene	induction|amod|START_ENTITY involvement|nmod|induction release|dep|involvement release|nmod|END_ENTITY	PGE2 release by bradykinin in human airway smooth muscle cells : involvement of cyclooxygenase-2 induction .
17089125	0	cyclooxygenase-2	18,34	caspase-3	64,73	cyclooxygenase-2	caspase-3	5743	836	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome_proliferator-activated_receptor-gamma agonists induced apoptosis in human monocyte leukemia cells in vitro .
11477578	0	cyclooxygenase-2	10,26	cox-2	28,33	cyclooxygenase-2	cox-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Increased cyclooxygenase-2 -LRB- cox-2 -RRB- expression and activity in a murine model of metastatic breast_cancer .
10381787	0	cyclooxygenase-2	68,84	cyclooxygenase-1	38,54	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|platelet platelet|amod|END_ENTITY	Dose-dependent inhibition of platelet cyclooxygenase-1 and monocyte cyclooxygenase-2 by meloxicam in healthy subjects .
10821698	0	cyclooxygenase-2	150,166	cyclooxygenase-1	94,110	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	selectivity|amod|START_ENTITY basis|nmod|selectivity analysis|dep|basis analysis|nmod|association association|nmod|diarylheterocycle diarylheterocycle|nmod|END_ENTITY	Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2 : dynamic basis of cyclooxygenase-2 selectivity .
11310210	0	cyclooxygenase-2	58,74	cyclooxygenase-1	26,42	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Interferon-alpha inhibits cyclooxygenase-1 and stimulates cyclooxygenase-2 expression in bladder_cancer cells in vitro .
11717412	0	cyclooxygenase-2	16,32	cyclooxygenase-1	109,125	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	inhibitor|amod|START_ENTITY level|nmod|inhibitor associated|nsubjpass|level associated|nmod|interference interference|nmod|inactivation inactivation|amod|END_ENTITY	A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin .
11752370	0	cyclooxygenase-2	28,44	cyclooxygenase-1	92,108	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|patient patient|acl:relcl|had had|dobj|reaction reaction|nmod|inhibitor inhibitor|amod|END_ENTITY	Anaphylactoid reaction to a cyclooxygenase-2 inhibitor in a patient who had a reaction to a cyclooxygenase-1 inhibitor .
11853875	0	cyclooxygenase-2	67,83	cyclooxygenase-1	87,103	cyclooxygenase-2	cyclooxygenase-1	19225(Tax:10090)	19224(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	The involvement of NF-kappaB in the constitutive overexpression of cyclooxygenase-2 in cyclooxygenase-1 null cells .
11861778	0	cyclooxygenase-2	17,33	cyclooxygenase-1	51,67	cyclooxygenase-2	cyclooxygenase-1	29527(Tax:10116)	24693(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1 : a key to nonsteroidal anti-inflammatory drug-induced intestinal_damage .
11959090	0	cyclooxygenase-2	28,44	cyclooxygenase-1	11,27	cyclooxygenase-2	cyclooxygenase-1	29527(Tax:10116)	24693(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY Effects|dep|inhibition Effects|nmod|END_ENTITY	Effects of cyclooxygenase-1 / cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery .
12708469	0	cyclooxygenase-2	19,35	cyclooxygenase-1	68,84	cyclooxygenase-2	cyclooxygenase-1	29527(Tax:10116)	24693(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Down-regulation|nmod|expression Down-regulation|nmod|model model|amod|END_ENTITY	Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal_carcinomas of the Eker -LRB- TSC2 gene mutant -RRB- rat model .
12743620	0	cyclooxygenase-2	79,95	cyclooxygenase-1	103,119	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	A model with original conditions and materials to test potential inhibitors of cyclooxygenase-2 versus cyclooxygenase-1 in isolated human blood cells .
14701858	0	cyclooxygenase-2	46,62	cyclooxygenase-1	96,112	cyclooxygenase-2	cyclooxygenase-1	19225(Tax:10090)	19224(Tax:10090)	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Rescue of female infertility from the loss of cyclooxygenase-2 by compensatory up-regulation of cyclooxygenase-1 is a function of genetic makeup .
15963707	0	cyclooxygenase-2	95,111	cyclooxygenase-1	73,89	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	regulated|xcomp|START_ENTITY regulated|advcl|END_ENTITY	Prostaglandin_E2 production in ovarian_cancer cell lines is regulated by cyclooxygenase-1 , not cyclooxygenase-2 .
16675095	0	cyclooxygenase-2	64,80	cyclooxygenase-1	93,109	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	Isosorbide_mononitrate induces increased cervical expression of cyclooxygenase-2 , but not of cyclooxygenase-1 , at term .
17915854	1	cyclooxygenase-2	103,119	cyclooxygenase-1	150,166	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	1,5-diarylpyrrol-3-acetic _ esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2 / cyclooxygenase-1 selectivity .
17915854	1	cyclooxygenase-2	133,149	cyclooxygenase-1	150,166	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	1,5-diarylpyrrol-3-acetic _ esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2 / cyclooxygenase-1 selectivity .
18349208	0	cyclooxygenase-2	69,85	cyclooxygenase-1	39,55	cyclooxygenase-2	cyclooxygenase-1	29527(Tax:10116)	24693(Tax:10116)	Gene	Gene	incisions|amod|START_ENTITY incisions|amod|END_ENTITY	Upregulation of dorsal horn microglial cyclooxygenase-1 and neuronal cyclooxygenase-2 after thoracic deep muscle incisions in the rat .
21301321	0	cyclooxygenase-2	64,80	cyclooxygenase-1	17,33	cyclooxygenase-2	cyclooxygenase-1	5743	5742	Gene	Gene	inhibition|amod|START_ENTITY efficacy|nmod|inhibition influence|nmod|efficacy influence|nmod|expression expression|amod|END_ENTITY	The influence of cyclooxygenase-1 expression on the efficacy of cyclooxygenase-2 inhibition in head_and_neck_squamous_cell_carcinoma cell lines .
17915854	1	cyclooxygenase-2	103,119	cyclooxygenase-2	133,149	cyclooxygenase-2	cyclooxygenase-2	5743	5743	Gene	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	1,5-diarylpyrrol-3-acetic _ esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2 / cyclooxygenase-1 selectivity .
17915854	1	cyclooxygenase-2	133,149	cyclooxygenase-2	103,119	cyclooxygenase-2	cyclooxygenase-2	5743	5743	Gene	Gene	selectivity|amod|START_ENTITY selectivity|amod|END_ENTITY	1,5-diarylpyrrol-3-acetic _ esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2 / cyclooxygenase-1 selectivity .
10501211	0	cyclooxygenase-2	207,223	cytosolic_phospholipase_A2	157,183	cyclooxygenase-2	cytosolic phospholipase A2	5743	5321	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Signaling mechanisms involved in the activation of arachidonic_acid metabolism in human astrocytoma cells by tumor_necrosis_factor-alpha : phosphorylation of cytosolic_phospholipase_A2 and transactivation of cyclooxygenase-2 .
22966331	0	cyclooxygenase-2	26,42	endothelin-1	10,22	cyclooxygenase-2	endothelin-1	5743	1906	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of endothelin-1 on cyclooxygenase-2 expression in human hormone refractory_prostate_cancer cells .
11910351	0	cyclooxygenase-2	18,34	epidermal_growth_factor_receptor	54,86	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Bile_acids induce cyclooxygenase-2 expression via the epidermal_growth_factor_receptor in a human cholangiocarcinoma cell line .
12684433	0	cyclooxygenase-2	27,43	epidermal_growth_factor_receptor	59,91	cyclooxygenase-2	epidermal growth factor receptor	19225(Tax:10090)	13649(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|ZD1839 ZD1839|compound|END_ENTITY	Combination of a selective cyclooxygenase-2 inhibitor with epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect .
15723947	0	cyclooxygenase-2	18,34	epidermal_growth_factor_receptor	84,116	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|expression expression|compound|END_ENTITY	Overexpression of cyclooxygenase-2 in nasopharyngeal_carcinoma and association with epidermal_growth_factor_receptor expression .
15838264	0	cyclooxygenase-2	24,40	epidermal_growth_factor_receptor	164,196	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nmod|pathways pathways|dep|evidence evidence|nmod|involvement involvement|nmod|transactivation transactivation|nmod|END_ENTITY	Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian_cancer cells through multiple signaling pathways : evidence for involvement of transactivation of the epidermal_growth_factor_receptor .
15914620	0	cyclooxygenase-2	119,135	epidermal_growth_factor_receptor	18,50	cyclooxygenase-2	epidermal growth factor receptor	29527(Tax:10116)	24329(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY leads|nmod|induction leads|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the epidermal_growth_factor_receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2 .
21199607	0	cyclooxygenase-2	97,113	epidermal_growth_factor_receptor	35,67	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	variables|amod|START_ENTITY phosphorylated|dobj|variables phosphorylated|nsubj|Correlations Correlations|nmod|expression expression|nmod|END_ENTITY	Correlations between expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , phosphorylated EGFR , cyclooxygenase-2 and clinicopathological variables and treatment outcomes in nasopharyngeal_carcinomas .
21435385	0	cyclooxygenase-2	29,45	epidermal_growth_factor_receptor	65,97	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nmod|END_ENTITY	Divalent lead cations induce cyclooxygenase-2 gene expression by epidermal_growth_factor_receptor / nuclear factor-kappa B signaling in A431carcinoma cells .
22048943	0	cyclooxygenase-2	27,43	epidermal_growth_factor_receptor	45,77	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	1|amod|START_ENTITY 1|amod|END_ENTITY	Prognostic significance of cyclooxygenase-2 , epidermal_growth_factor_receptor 1 , and microvascular density in gastric_cancer .
23355539	0	cyclooxygenase-2	19,35	epidermal_growth_factor_receptor	51,83	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Lapatinib-mediated cyclooxygenase-2 expression via epidermal_growth_factor_receptor / HuR interaction enhances the aggressiveness of triple-negative breast_cancer cells .
23973650	0	cyclooxygenase-2	13,29	epidermal_growth_factor_receptor	151,183	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 expression by prostaglandin_E2 stimulation of the prostanoid_EP4_receptor via coupling to Gai and transactivation of the epidermal_growth_factor_receptor in HCA-7 human colon_cancer cells .
25225463	0	cyclooxygenase-2	95,111	epidermal_growth_factor_receptor	14,46	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	epidermal|amod|START_ENTITY epidermal|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
26464643	0	cyclooxygenase-2	80,96	epidermal_growth_factor_receptor	21,53	cyclooxygenase-2	epidermal growth factor receptor	5743	1956	Gene	Gene	Level|amod|START_ENTITY mutation|dobj|Level mutation|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship between epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation and serum cyclooxygenase-2 Level , and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small_cell_lung_cancer cells .
12438555	0	cyclooxygenase-2	92,108	gastrin	48,55	cyclooxygenase-2	gastrin	29527(Tax:10116)	25320(Tax:10116)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Lansoprazole induces mucosal protection through gastrin receptor-dependent up-regulation of cyclooxygenase-2 in rats .
12674216	0	cyclooxygenase-2	42,58	gastrin	13,20	cyclooxygenase-2	gastrin	5743	2520	Gene	Gene	proteins|amod|START_ENTITY expression|nmod|proteins Influence|nmod|expression Influence|nmod|END_ENTITY	Influence of gastrin on the expression of cyclooxygenase-2 , hepatocyte_growth_factor and apoptosis-related proteins in gastric epithelial cells .
16254046	0	cyclooxygenase-2	15,31	gastrin	66,73	cyclooxygenase-2	gastrin	19225(Tax:10090)	14459(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gastric_mucosal_hypertrophy gastric_mucosal_hypertrophy|nmod|END_ENTITY	Involvement of cyclooxygenase-2 in gastric_mucosal_hypertrophy in gastrin transgenic_mice .
23587883	0	cyclooxygenase-2	64,80	glial_cell_line-derived_neurotrophic_factor	12,55	cyclooxygenase-2	glial cell line-derived neurotrophic factor	29527(Tax:10116)	25453(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Upregulated glial_cell_line-derived_neurotrophic_factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats .
16036795	0	cyclooxygenase-2	27,43	glucose-related_protein_78	94,120	cyclooxygenase-2	glucose-related protein 78	19225(Tax:10090)	3309	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Up-regulation of astrocyte cyclooxygenase-2 , CCAAT/enhancer-binding _ protein-homology protein , glucose-related_protein_78 , eukaryotic initiation factor 2 alpha , and c-Jun N-terminal kinase by a neurovirulent murine retrovirus .
16371352	0	cyclooxygenase-2	14,30	glycogen_synthase_kinase-3beta	47,77	cyclooxygenase-2	glycogen synthase kinase-3beta	5743	2932	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of cyclooxygenase-2 is regulated by glycogen_synthase_kinase-3beta in gastric_cancer cells .
14751415	0	cyclooxygenase-2	14,30	hepatocyte_growth_factor	64,88	cyclooxygenase-2	hepatocyte growth factor	29527(Tax:10116)	24446(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY reduces|nsubj|Inhibition reduces|dobj|effect effect|nmod|END_ENTITY	Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte_growth_factor in experimental pancreatitis .
17550984	0	cyclooxygenase-2	31,47	hepatocyte_growth_factor	61,85	cyclooxygenase-2	hepatocyte growth factor	5743	3082	Gene	Gene	induction|amod|START_ENTITY involved|nmod|induction involved|nmod|END_ENTITY	Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte_growth_factor in non_small-cell_lung_cancer .
21687953	0	cyclooxygenase-2	30,46	hepatocyte_growth_factor	64,88	cyclooxygenase-2	hepatocyte growth factor	5743	3082	Gene	Gene	up-regulation|amod|START_ENTITY involved|nmod|up-regulation involved|nmod|END_ENTITY	Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte_growth_factor in endometrial_cancer cells .
11939728	0	cyclooxygenase-2	17,33	inducible_nitric_oxide_synthase	121,152	cyclooxygenase-2	inducible nitric oxide synthase	5743	4843	Gene	Gene	expression|amod|START_ENTITY Up-regulation|nmod|expression Up-regulation|dep|correlation correlation|nmod|END_ENTITY	Up-regulation of cyclooxygenase-2 expression in lymphocytic_thyroiditis_and_thyroid_tumors : significant correlation with inducible_nitric_oxide_synthase .
15740981	0	cyclooxygenase-2	92,108	inducible_nitric_oxide_synthase	33,64	cyclooxygenase-2	inducible nitric oxide synthase	29527(Tax:10116)	24599(Tax:10116)	Gene	Gene	pleurisy|amod|START_ENTITY that|nmod|pleurisy expression|nmod|that expression|nmod|END_ENTITY	Local and systemic expression of inducible_nitric_oxide_synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy .
16518418	0	cyclooxygenase-2	129,145	inducible_nitric_oxide_synthase	147,178	cyclooxygenase-2	inducible nitric oxide synthase	5743	4843	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2 , inducible_nitric_oxide_synthase , and hypoxia-inducible_factor_1alpha expression , resulting in reduced angiogenesis .
20546946	0	cyclooxygenase-2	109,125	inducible_nitric_oxide_synthase	76,107	cyclooxygenase-2	inducible nitric oxide synthase	19225(Tax:10090)	18126(Tax:10090)	Gene	Gene	isolated|xcomp|START_ENTITY isolated|nmod|heartwood heartwood|nmod|END_ENTITY	Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible_nitric_oxide_synthase , cyclooxygenase-2 , and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells .
19058305	0	cyclooxygenase-2	58,74	interferon-alpha-2b	21,40	cyclooxygenase-2	interferon-alpha-2b	5743	3440	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of interferon-alpha-2b on expression of cyclooxygenase-2 and vascular_endothelial_growth_factor in human hepatocellular_carcinoma inoculated in nude_mice .
15465602	0	cyclooxygenase-2	62,78	interferon-gamma	24,40	cyclooxygenase-2	interferon-gamma	5743	3458	Gene	Gene	expression|nmod|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Differential effects of interferon-gamma on the expression of cyclooxygenase-2 in high-grade human gliomas versus primary astrocytes .
9041934	0	cyclooxygenase-2	59,75	interleukin-1	90,103	cyclooxygenase-2	interleukin-1	5743	3552	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression Involvement|nmod|regulation Involvement|nmod|END_ENTITY	Involvement of nuclear_factor_kappa_B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid_synoviocytes .
9057644	0	cyclooxygenase-2	50,66	interleukin-10	14,28	cyclooxygenase-2	interleukin-10	5743	3586	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils .
8163473	0	cyclooxygenase-2	13,29	interleukin-1_alpha	33,52	cyclooxygenase-2	interleukin-1 alpha	5743	3552	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 by interleukin-1_alpha .
10810453	0	cyclooxygenase-2	27,43	interleukin-1_beta	70,88	cyclooxygenase-2	interleukin-1 beta	5743	3553	Gene	Gene	stability|amod|START_ENTITY stability|nmod|IL-1_beta IL-1_beta|amod|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
11352510	0	cyclooxygenase-2	27,43	interleukin-1_beta	124,142	cyclooxygenase-2	interleukin-1 beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|mobilization mobilization|nmod|fibroblasts fibroblasts|acl|primed primed|advcl|END_ENTITY	Bradykinin induces a rapid cyclooxygenase-2 mRNA expression via Ca2 + mobilization in human gingival fibroblasts primed with interleukin-1_beta .
18571585	0	cyclooxygenase-2	114,130	interleukin-1_beta	25,43	cyclooxygenase-2	interleukin-1 beta	5743	3553	Gene	Gene	upregulation|nmod|START_ENTITY cell-derived|nmod|upregulation cell-derived|dobj|chemoresistance chemoresistance|amod|END_ENTITY	Mononuclear cell-derived interleukin-1_beta confers chemoresistance in pancreatic_cancer cells by upregulation of cyclooxygenase-2 .
8891309	0	cyclooxygenase-2	55,71	interleukin-1_beta	101,119	cyclooxygenase-2	interleukin-1 beta	29527(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY express|dobj|mRNA express|nmod|synthesis synthesis|amod|END_ENTITY	Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1_beta : a possible site of prostaglandin synthesis responsible for fever .
25976054	0	cyclooxygenase-2	48,64	interleukin-1b	26,40	cyclooxygenase-2	interleukin-1b	5743	3553	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Regulatory mechanisms of interleukin-1b on the cyclooxygenase-2 system expression of human neuroglioma cells -RSB- .
10523409	0	cyclooxygenase-2	13,29	interleukin-1beta	84,101	cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta : involvement of p38_mitogen-activated_protein_kinase .
11082190	0	cyclooxygenase-2	76,92	interleukin-1beta	115,132	cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	gene|amod|START_ENTITY stimulation|nmod|gene factors|nmod|stimulation role|nmod|factors transcription|nsubj|role transcription|nmod|END_ENTITY	Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1beta in articular chondrocytes .
12727794	0	cyclooxygenase-2	14,30	interleukin-1beta	55,72	cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY Expression|nmod|expression Expression|acl|END_ENTITY	Expression of cyclooxygenase-2 parallels expression of interleukin-1beta , interleukin-6 and NF-kappaB in human colorectal_cancer .
15067222	0	cyclooxygenase-2	13,29	interleukin-1beta	82,99	cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Induction of cyclooxygenase-2 expression in human tracheal smooth muscle cells by interleukin-1beta : involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-kappaB .
15950779	0	cyclooxygenase-2	18,34	interleukin-1beta	45,62	cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	system|amod|START_ENTITY system|nmod|pathways pathways|amod|END_ENTITY	Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways : a comparative study of human neuroglioma_and_neuroblastoma cells .
17074047	0	cyclooxygenase-2	15,31	interleukin-1beta	56,73	cyclooxygenase-2	interleukin-1beta	29527(Tax:10116)	24494(Tax:10116)	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain .
18262365	0	cyclooxygenase-2	82,98	interleukin-1beta	8,25	cyclooxygenase-2	interleukin-1beta	19225(Tax:10090)	16176(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY Role|nmod|mRNA Role|nmod|expression expression|amod|END_ENTITY	Role of interleukin-1beta and tumor_necrosis_factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic_inflammation in mice .
19029777	0	cyclooxygenase-2	13,29	interleukin-1beta	44,61	cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|line line|amod|END_ENTITY	Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line , U87MG .
20424388	0	cyclooxygenase-2	35,51	interleukin-1beta	67,84	cyclooxygenase-2	interleukin-1beta	29527(Tax:10116)	24494(Tax:10116)	Gene	Gene	expressing|xcomp|START_ENTITY expressing|nmod|END_ENTITY	Identification of cells expressing cyclooxygenase-2 in response to interleukin-1beta in rat aortae .
9275047	0	cyclooxygenase-2	13,29	interleukin-1beta	79,96	cyclooxygenase-2	interleukin-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 and prostaglandin_F2alpha_receptor expression by interleukin-1beta in cultured human granulosa-luteal cells .
9632078	0	cyclooxygenase-2	14,30	interleukin_1alpha	79,97	cyclooxygenase-2	interleukin 1alpha	282023(Tax:9913)	281250(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin_1alpha , tumor_necrosis_factor-alpha , glucocorticoids , and 17beta-estradiol .
16001969	0	cyclooxygenase-2	70,86	nuclear_factor-kappaB	131,152	cyclooxygenase-2	nuclear factor-kappaB	5743	4790	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|mechanism mechanism|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear_factor-kappaB and activating protein-1 mediated mechanism .
16204946	0	cyclooxygenase-2	82,98	nuclear_factor-kappaB	134,155	cyclooxygenase-2	nuclear factor-kappaB	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	START_ENTITY|nmod|chiisanoside chiisanoside|nmod|suppression suppression|nmod|activation activation|amod|END_ENTITY	Inhibition of lipopolysaccharide-induced expression of inducible nitric_oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear_factor-kappaB activation in RAW 264.7 macrophage cells .
16682957	0	cyclooxygenase-2	30,46	nuclear_factor-kappaB	80,101	cyclooxygenase-2	nuclear factor-kappaB	5743	4790	Gene	Gene	p53|amod|START_ENTITY activation|nmod|p53 requires|nsubj|activation requires|xcomp|END_ENTITY	Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear_factor-kappaB .
17434257	0	cyclooxygenase-2	38,54	nuclear_factor-kappaB	74,95	cyclooxygenase-2	nuclear factor-kappaB	5743	4790	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|responses responses|amod|END_ENTITY	Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear_factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression .
9679714	0	cyclooxygenase-2	13,29	nuclear_factor-kappaB	48,69	cyclooxygenase-2	nuclear factor-kappaB	5743	4790	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 and activation of nuclear_factor-kappaB in myocardium of patients with congestive_heart_failure .
12771929	0	cyclooxygenase-2	16,32	nuclear_factor-kappa_B	75,97	cyclooxygenase-2	nuclear factor-kappa B	5743	4790	Gene	Gene	Upregulation|nmod|START_ENTITY accompanied|nsubjpass|Upregulation accompanied|nmod|expression expression|nmod|END_ENTITY	Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear_factor-kappa_B and I_kappa_B_kinase-alpha in human colorectal_cancer epithelial cells .
15655349	0	cyclooxygenase-2	27,43	nuclear_factor-kappa_B	71,93	cyclooxygenase-2	nuclear factor-kappa B	5743	4790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
16841079	0	cyclooxygenase-2	45,61	nuclear_factor-kappa_B	19,41	cyclooxygenase-2	nuclear factor-kappa B	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	overexpression|amod|START_ENTITY END_ENTITY|nmod|overexpression	The involvement of nuclear_factor-kappa_B in cyclooxygenase-2 overexpression in murine colon_cancer cells transduced with herpes simplex virus thymidine kinase gene .
17335379	0	cyclooxygenase-2	12,28	nuclear_factor-kappa_B	110,132	cyclooxygenase-2	nuclear factor-kappa B	5743	4790	Gene	Gene	inhibitor|amod|START_ENTITY Effect|nmod|inhibitor Effect|nmod|END_ENTITY	Effect of a cyclooxygenase-2 inhibitor on interleukin-1beta-stimulated activation of the transcription factor nuclear_factor-kappa_B in human gingival fibroblasts .
18534633	0	cyclooxygenase-2	15,31	nuclear_factor-kappa_B	51,73	cyclooxygenase-2	nuclear factor-kappa B	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nmod|activation activation|amod|END_ENTITY	Hemin inhibits cyclooxygenase-2 expression through nuclear_factor-kappa_B activation and ornithine_decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin .
16269535	0	cyclooxygenase-2	200,216	nuclear_factor_kappaB	178,199	cyclooxygenase-2	nuclear factor kappaB	19225(Tax:10090)	18033(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma : involvement of alpha-melanocyte-stimulating_hormone-mediated inhibition of the nuclear_factor_kappaB / cyclooxygenase-2 pathway .
9041934	0	cyclooxygenase-2	59,75	nuclear_factor_kappa_B	15,37	cyclooxygenase-2	nuclear factor kappa B	5743	4790	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression Involvement|nmod|regulation Involvement|nmod|END_ENTITY	Involvement of nuclear_factor_kappa_B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid_synoviocytes .
15386340	0	cyclooxygenase-2	192,208	ornithine_decarboxylase	210,233	cyclooxygenase-2	ornithine decarboxylase	19225(Tax:10090)	18263(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Development of a chemoresistant orthotopic human nonsmall_cell_lung_carcinoma model in nude_mice : analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2 , ornithine_decarboxylase , lung-related resistance protein , prostaglandin_E synthetase , and glutathione-S-transferase-alpha -LRB- GST -RRB- - alpha , GST-mu , and GST-pi .
12370831	0	cyclooxygenase-2	31,47	p38	12,15	cyclooxygenase-2	p38	5743	1432	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line , HaCaT .
15753376	0	cyclooxygenase-2	14,30	p38	0,3	cyclooxygenase-2	p38	5743	1432	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue .
16256948	0	cyclooxygenase-2	25,41	p38	123,126	cyclooxygenase-2	p38	5743	1432	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Prostaglandin_E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases .
10523409	0	cyclooxygenase-2	13,29	p38_mitogen-activated_protein_kinase	118,154	cyclooxygenase-2	p38 mitogen-activated protein kinase	5743	1432	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|dep|involvement involvement|nmod|END_ENTITY	Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta : involvement of p38_mitogen-activated_protein_kinase .
11466386	0	cyclooxygenase-2	19,35	p38_mitogen-activated_protein_kinase	110,146	cyclooxygenase-2	p38 mitogen-activated protein kinase	29527(Tax:10116)	81649(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY associated|nsubjpass|levels associated|nmod|activation activation|nmod|END_ENTITY	Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38_mitogen-activated_protein_kinase .
11795877	0	cyclooxygenase-2	80,96	p38_mitogen-activated_protein_kinase	8,44	cyclooxygenase-2	p38 mitogen-activated protein kinase	29527(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of p38_mitogen-activated_protein_kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression .
17208222	0	cyclooxygenase-2	25,41	p38_mitogen-activated_protein_kinase	61,97	cyclooxygenase-2	p38 mitogen-activated protein kinase	5743	1432	Gene	Gene	mRNA|amod|START_ENTITY destabilizes|dobj|mRNA destabilizes|advcl|inhibiting inhibiting|dobj|shuttling shuttling|amod|END_ENTITY	Thalidomide destabilizes cyclooxygenase-2 mRNA by inhibiting p38_mitogen-activated_protein_kinase and cytoplasmic shuttling of HuR .
17482227	0	cyclooxygenase-2	42,58	p38_mitogen-activated_protein_kinase	78,114	cyclooxygenase-2	p38 mitogen-activated protein kinase	5743	1432	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	2,2 ' ,4,4 ' - Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38_mitogen-activated_protein_kinase and NF-kappaB .
9867839	0	cyclooxygenase-2	47,63	p38_mitogen-activated_protein_kinase	0,36	cyclooxygenase-2	p38 mitogen-activated protein kinase	5743	1432	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	p38_mitogen-activated_protein_kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes .
10196169	0	cyclooxygenase-2	14,30	p53	50,53	cyclooxygenase-2	p53	19225(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|END_ENTITY	Inhibition of cyclooxygenase-2 gene expression by p53 .
12469191	0	cyclooxygenase-2	14,30	p53	55,58	cyclooxygenase-2	p53	5743	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|accumulation accumulation|compound|END_ENTITY	Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian_adenocarcinomas .
14760075	0	cyclooxygenase-2	9,25	p53	78,81	cyclooxygenase-2	p53	5743	7157	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|nmod|END_ENTITY	Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4 , amplification of HER-2 / neu , and poor outcome in serous ovarian_carcinoma .
15287038	0	cyclooxygenase-2	40,56	p53	11,14	cyclooxygenase-2	p53	5743	7157	Gene	Gene	expression|amod|START_ENTITY overexpression|nmod|expression overexpression|nsubj|Effects Effects|nmod|END_ENTITY	Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head_and_neck_squamous_cell_carcinoma cell lines .
15921850	0	cyclooxygenase-2	14,30	p53	79,82	cyclooxygenase-2	p53	5743	7157	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|accumulation accumulation|compound|END_ENTITY	Expression of cyclooxygenase-2 in colorectal_adenocarcinoma is associated with p53 accumulation and hdm2 overexpression .
16733863	0	cyclooxygenase-2	14,30	p53	50,53	cyclooxygenase-2	p53	5743	7157	Gene	Gene	Expression|nmod|START_ENTITY associated|nsubjpass|Expression associated|nmod|accumulation accumulation|compound|END_ENTITY	Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant_gallbladder_lesions .
16996907	0	cyclooxygenase-2	21,37	p53	54,57	cyclooxygenase-2	p53	5743	7157	Gene	Gene	expression|amod|START_ENTITY analysis|nmod|expression analysis|nmod|END_ENTITY	Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall_cell_lung_cancer .
17594159	0	cyclooxygenase-2	14,30	p53	55,58	cyclooxygenase-2	p53	5743	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|accumulation accumulation|compound|END_ENTITY	Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal_cancers .
19217709	0	cyclooxygenase-2	32,48	p53	8,11	cyclooxygenase-2	p53	5743	7157	Gene	Gene	lines|amod|START_ENTITY induction|nmod|lines Role|nmod|induction Role|nmod|END_ENTITY	Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung_cancer cell lines .
25225463	0	cyclooxygenase-2	95,111	p53	48,51	cyclooxygenase-2	p53	5743	7157	Gene	Gene	epidermal|amod|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
8995303	0	cyclooxygenase-2	16,32	p65	51,54	cyclooxygenase-2	p65	5743	5970	Gene	Gene	START_ENTITY|nmod|factor factor|amod|END_ENTITY	Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells .
17645771	0	cyclooxygenase-2	15,31	parathyroid_hormone-related_protein	74,109	cyclooxygenase-2	parathyroid hormone-related protein	19225(Tax:10090)	19227(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid_hormone-related_protein in colon 26 carcinoma .
12736714	0	cyclooxygenase-2	14,30	peroxisome_proliferator-activated_receptor-gamma	49,97	cyclooxygenase-2	peroxisome proliferator-activated receptor-gamma	5743	5468	Gene	Gene	START_ENTITY|nmod|synergistically synergistically|amod|END_ENTITY	Inhibition of cyclooxygenase-2 and activation of peroxisome_proliferator-activated_receptor-gamma synergistically induces apoptosis and inhibits growth of human breast_cancer cells .
11963834	0	cyclooxygenase-2	37,53	phospholipase-A2	71,87	cyclooxygenase-2	phospholipase-A2	5743	151056	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Site-specific augmentation of amnion cyclooxygenase-2 and decidua vera phospholipase-A2 expression in labor : possible contribution of mechanical stretch and interleukin-1 to amnion prostaglandin synthesis .
10533051	0	cyclooxygenase-2	194,210	platelet-activating_factor	137,163	cyclooxygenase-2	platelet-activating factor	29527(Tax:10116)	300795(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mediator|nmod|expression END_ENTITY|nmod|mediator	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
10533051	0	cyclooxygenase-2	43,59	platelet-activating_factor	137,163	cyclooxygenase-2	platelet-activating factor	29527(Tax:10116)	300795(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
20025057	0	cyclooxygenase-2	14,30	prostaglandin-E_synthase	46,70	cyclooxygenase-2	prostaglandin-E synthase	29527(Tax:10116)	59103(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of cyclooxygenase-2 and microsomal prostaglandin-E_synthase in amoeboid microglial cells in the developing brain and effects of cyclooxygenase-2 neutralization on BV-2 microglial cells .
23973650	0	cyclooxygenase-2	13,29	prostanoid_EP4_receptor	80,103	cyclooxygenase-2	prostanoid EP4 receptor	5743	5734	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 expression by prostaglandin_E2 stimulation of the prostanoid_EP4_receptor via coupling to Gai and transactivation of the epidermal_growth_factor_receptor in HCA-7 human colon_cancer cells .
19169273	0	cyclooxygenase-2	34,50	protein_kinase_C-delta	81,103	cyclooxygenase-2	protein kinase C-delta	5743	5580	Gene	Gene	induction|amod|START_ENTITY requires|nsubj|induction requires|dobj|END_ENTITY	Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein_kinase_C-delta .
10564233	0	cyclooxygenase-2	85,101	renin	38,43	cyclooxygenase-2	renin	5743	5972	Gene	Gene	blockade|nmod|START_ENTITY secretion|nmod|blockade secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2 .
10954003	0	cyclooxygenase-2	8,24	renin	65,70	cyclooxygenase-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY blunts|nsubj|inhibition blunts|dobj|END_ENTITY	Chronic cyclooxygenase-2 inhibition blunts low sodium-stimulated renin without changing renal haemodynamics .
11316844	0	cyclooxygenase-2	21,37	renin	96,101	cyclooxygenase-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|secretion secretion|compound|END_ENTITY	Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion .
11680616	0	cyclooxygenase-2	14,30	renin	95,100	cyclooxygenase-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	attenuates|amod|START_ENTITY Inhibition|nmod|attenuates prostanoid_excretion|nsubj|Inhibition prostanoid_excretion|advcl|affecting affecting|dobj|expression expression|compound|END_ENTITY	Inhibition of cyclooxygenase-2 attenuates urinary prostanoid_excretion without affecting renal renin expression .
12434137	0	cyclooxygenase-2	11,27	renin	67,72	cyclooxygenase-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Effects of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on plasma and renal renin in diabetes .
12456386	0	cyclooxygenase-2	14,30	renin	43,48	cyclooxygenase-2	renin	443460(Tax:9940)	443310(Tax:9940)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|effects effects|nmod|secretion secretion|compound|END_ENTITY	Inhibition of cyclooxygenase-2 : effects on renin secretion and expression in fetal lambs .
19861503	0	cyclooxygenase-2	58,74	renin	112,117	cyclooxygenase-2	renin	29527(Tax:10116)	24715(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced -LRB- Pro -RRB- renin receptor expression .
16489006	0	cyclooxygenase-2	15,31	transforming_growth_factor-beta	59,90	cyclooxygenase-2	transforming growth factor-beta	5743	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of cyclooxygenase-2 expression by bone-derived transforming_growth_factor-beta enhances bone metastases in breast_cancer .
11289153	0	cyclooxygenase-2	27,43	tumor_necrosis_factor-alpha	66,93	cyclooxygenase-2	tumor necrosis factor-alpha	5743	7124	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of cyclooxygenase-2 and its regulation by tumor_necrosis_factor-alpha in normal and malignant prostate cells .
19174152	0	cyclooxygenase-2	77,93	tumor_necrosis_factor-alpha	116,143	cyclooxygenase-2	tumor necrosis factor-alpha	19225(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor_necrosis_factor-alpha .
23117931	0	cyclooxygenase-2	79,95	vascular_cell_adhesion_molecule-1	97,130	cyclooxygenase-2	vascular cell adhesion molecule-1	5743	7412	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The androgen metabolite , 5a-androstane-3b ,17 b-diol , decreases cytokine-induced cyclooxygenase-2 , vascular_cell_adhesion_molecule-1 expression , and P-glycoprotein expression in male human brain microvascular endothelial cells .
10919714	0	cyclooxygenase-2	127,143	vascular_endothelial_growth_factor	16,50	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	line|amod|START_ENTITY induction|nmod|line mediated|nmod|induction mediated|nsubjpass|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor by cobalt_chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human_prostate_cancer cell line .
11381123	0	cyclooxygenase-2	13,29	vascular_endothelial_growth_factor	93,127	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	Induction|nmod|START_ENTITY involved|nsubjpass|Induction involved|nmod|production production|compound|END_ENTITY	Induction of cyclooxygenase-2 by Epstein-Barr_virus latent membrane protein 1 is involved in vascular_endothelial_growth_factor production in nasopharyngeal_carcinoma cells .
14558947	0	cyclooxygenase-2	21,37	vascular_endothelial_growth_factor	74,108	cyclooxygenase-2	vascular endothelial growth factor	19225(Tax:10090)	22339(Tax:10090)	Gene	Gene	celebrex|amod|START_ENTITY celebrex|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in pancreatic_carcinoma -RSB- .
15585326	0	cyclooxygenase-2	4,20	vascular_endothelial_growth_factor	45,79	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	DFU|amod|START_ENTITY regulates|nsubj|DFU regulates|dobj|expression expression|compound|END_ENTITY	New cyclooxygenase-2 inhibitor DFU regulates vascular_endothelial_growth_factor expression in rheumatoid_synoviocytes .
15704107	0	cyclooxygenase-2	6,22	vascular_endothelial_growth_factor	50,84	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	levels|amod|START_ENTITY correlate|nsubj|levels correlate|nmod|levels levels|compound|END_ENTITY	Total cyclooxygenase-2 mRNA levels correlate with vascular_endothelial_growth_factor mRNA levels , tumor angiogenesis and prognosis in non-small_cell_lung_cancer patients .
16015035	0	cyclooxygenase-2	163,179	vascular_endothelial_growth_factor	10,44	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	NS-398|amod|START_ENTITY target|nmod|NS-398 represents|dobj|target END_ENTITY|parataxis|represents	Autocrine vascular_endothelial_growth_factor / vascular_endothelial_growth_factor_receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon_cancer cells .
16515599	0	cyclooxygenase-2	14,30	vascular_endothelial_growth_factor	80,114	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|expression expression|compound|END_ENTITY	Expression of cyclooxygenase-2 in epithelial_ovarian_tumors and its relation to vascular_endothelial_growth_factor and p53 expression .
20222044	0	cyclooxygenase-2	29,45	vascular_endothelial_growth_factor	70,104	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	inhibitors|amod|START_ENTITY effects|nmod|inhibitors effects|nmod|production production|compound|END_ENTITY	Differential effects between cyclooxygenase-2 inhibitors and siRNA on vascular_endothelial_growth_factor production in head_and_neck_squamous_cell_carcinoma cell lines .
20939988	0	cyclooxygenase-2	192,208	vascular_endothelial_growth_factor	79,113	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	-RSB-|amod|START_ENTITY inhibiting|dobj|-RSB- induced|advcl|inhibiting MKN45|acl|induced END_ENTITY|nmod|MKN45	-LSB- Chinese herbal medicine Jianpi Jiedu Formula down-regulates the expression of vascular_endothelial_growth_factor in human gastric cell line MKN45 induced by Helicobacter_pylori by inhibiting cyclooxygenase-2 -RSB- .
22009181	0	cyclooxygenase-2	27,43	vascular_endothelial_growth_factor	57,91	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|nmod|expression expression|compound|END_ENTITY	Dual action of a selective cyclooxygenase-2 inhibitor on vascular_endothelial_growth_factor expression in human hepatocellular_carcinoma cells : novel involvement of discoidin_domain_receptor_2 .
25225463	0	cyclooxygenase-2	95,111	vascular_endothelial_growth_factor	59,93	cyclooxygenase-2	vascular endothelial growth factor	5743	7422	Gene	Gene	epidermal|amod|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
26498481	0	cyclooxygenase-2_and_nuclear_factor-kB	10,48	p65	49,52	cyclooxygenase-2 and nuclear factor-kB	p65	19225(Tax:10090)	19697(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Increased cyclooxygenase-2_and_nuclear_factor-kB / p65 expression in mouse hippocampi after systemic administration of tetanus toxin .
24694232	0	cyclooxygenase_1_and_2	87,109	PTGS1	111,116	cyclooxygenase 1 and 2	PTGS1	5742;5743	5742	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Gene variants and haplotypes modifying transcription factor binding sites in the human cyclooxygenase_1_and_2 -LRB- PTGS1 and PTGS2 -RRB- genes .
16376136	0	cyclooxygenase_2	82,98	Amphiregulin	0,12	cyclooxygenase 2	Amphiregulin	5743	374	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Amphiregulin as a tumor promoter for oral_squamous_cell_carcinoma : involvement of cyclooxygenase_2 .
22791338	0	cyclooxygenase_2	57,73	Annexin_A1	0,10	cyclooxygenase 2	Annexin A1	29527(Tax:10116)	25380(Tax:10116)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Annexin_A1 modulates macula densa function by inhibiting cyclooxygenase_2 .
10987308	0	cyclooxygenase_2	14,30	COX-2	32,37	cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cyclooxygenase_2 -LRB- COX-2 -RRB- in human glioma and in vitro inhibition by a specific COX-2 inhibitor , NS-398 .
11229771	0	cyclooxygenase_2	9,25	COX-2	27,32	cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Pimarane cyclooxygenase_2 -LRB- COX-2 -RRB- inhibitor and its structure-activity relationship .
11468975	0	cyclooxygenase_2	11,27	COX-2	40,45	cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Selective cyclooxygenase_2 inhibitors -LRB- COX-2 -RRB- -RSB- .
14688483	0	cyclooxygenase_2	12,28	COX-2	30,35	cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of cyclooxygenase_2 -LRB- COX-2 -RRB- expression during malignant_melanoma_progression .
17350020	0	cyclooxygenase_2	54,70	COX-2	72,77	cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Increased risk of incident stroke associated with the cyclooxygenase_2 -LRB- COX-2 -RRB- G-765C polymorphism in African-Americans : the Atherosclerosis Risk in Communities Study .
17479405	0	cyclooxygenase_2	32,48	COX-2	50,55	cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms in the cyclooxygenase_2 -LRB- COX-2 -RRB- gene and risk of breast_cancer in a Chinese population .
24988319	0	cyclooxygenase_2	26,42	COX-2	44,49	cyclooxygenase 2	COX-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Reversible suppression of cyclooxygenase_2 -LRB- COX-2 -RRB- expression in vivo by inducible RNA interference .
8789408	0	cyclooxygenase_2	15,31	COX-2	33,38	cyclooxygenase 2	COX-2	100135607(Tax:10141)	100135607(Tax:10141)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of cyclooxygenase_2 -LRB- COX-2 -RRB- in intrinsic tone of isolated guinea_pig trachea .
21035557	0	cyclooxygenase_2	75,91	COX2	93,97	cyclooxygenase 2	COX2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Selenomethionine inhibits IL-1b inducible nitric_oxide synthase -LRB- iNOS -RRB- and cyclooxygenase_2 -LRB- COX2 -RRB- expression in primary human chondrocytes .
21803118	0	cyclooxygenase_2	29,45	COX2	47,51	cyclooxygenase 2	COX2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prolactin -LRB- PRL -RRB- induction of cyclooxygenase_2 -LRB- COX2 -RRB- expression and prostaglandin -LRB- PG -RRB- production in hamster Leydig cells .
19208339	0	cyclooxygenase_2	59,75	HuR	26,29	cyclooxygenase 2	HuR	5743	1994	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase_2 expression during colon_carcinogenesis .
11250126	0	cyclooxygenase_2	26,42	Interleukin-1beta	0,17	cyclooxygenase 2	Interleukin-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	Interleukin-1beta induced cyclooxygenase_2 expression and prostaglandin_E2 secretion by human neuroblastoma cells : implications for Alzheimer 's _ disease .
24360742	0	cyclooxygenase_2	39,55	Leucine-rich_repeat_kinase_2	0,28	cyclooxygenase 2	Leucine-rich repeat kinase 2	5743	120892	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Leucine-rich_repeat_kinase_2 modulates cyclooxygenase_2 and the inflammatory response in idiopathic and genetic Parkinson 's _ disease .
16085694	0	cyclooxygenase_2	50,66	Monocyte_chemoattractant_protein_1	0,34	cyclooxygenase 2	Monocyte chemoattractant protein 1	5743	6347	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Monocyte_chemoattractant_protein_1 and macrophage cyclooxygenase_2 expression in colonic_adenoma .
16397300	0	cyclooxygenase_2	106,122	NF-IL6beta	19,29	cyclooxygenase 2	NF-IL6beta	5743	1052	Gene	Gene	gene|amod|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase_2 gene .
18025233	0	cyclooxygenase_2	36,52	NF-kappaB-inducing_kinase	0,25	cyclooxygenase 2	NF-kappaB-inducing kinase	5743	9020	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappaB-inducing_kinase regulates cyclooxygenase_2 gene expression in macrophages by phosphorylation of PU .1 .
15843495	0	cyclooxygenase_2	31,47	PPARG	62,67	cyclooxygenase 2	PPARG	5743	5468	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Modulation of cytokine-induced cyclooxygenase_2 expression by PPARG ligands through NFkappaB signal disruption in human WISH and amnion cells .
21481131	0	cyclooxygenase_2	37,53	PTGS2	67,72	cyclooxygenase 2	COX-2	5743	5743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Associations between variants in the cyclooxygenase_2 enzyme gene -LRB- PTGS2 -RRB- and development of benign_prostate_enlargement .
20862685	0	cyclooxygenase_2	68,84	SET-1A	36,42	cyclooxygenase 2	SET-1A	5743	9739	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase_2 and inducible nitric_oxide synthase expression in human osteoarthritis chondrocytes .
15667946	0	cyclooxygenase_2	31,47	catalase	14,22	cyclooxygenase 2	catalase	5743	847	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Extracellular catalase induces cyclooxygenase_2 , interleukin_8 , and stromelysin genes in primary human chondrocytes .
10448889	0	cyclooxygenase_2	57,73	endothelin-1	14,26	cyclooxygenase 2	endothelin-1	19225(Tax:10090)	13614(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Modulation by endothelin-1 of lipopolysaccharide-induced cyclooxygenase_2 expression in mouse peritoneal macrophages .
19505922	0	cyclooxygenase_2	6,22	matrix_metalloproteinase_7	28,54	cyclooxygenase 2	matrix metalloproteinase 7	5743	4316	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Fecal cyclooxygenase_2 plus matrix_metalloproteinase_7 mRNA assays as a marker for colorectal_cancer screening .
11840453	0	cyclooxygenase_2	122,138	peroxisome_proliferator-activated_receptor	66,108	cyclooxygenase 2	peroxisome proliferator-activated receptor	5743	5465	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Nimesulide , a preferential cyclooxygenase_2 inhibitor , suppresses peroxisome_proliferator-activated_receptor induction of cyclooxygenase_2 gene expression in human synovial fibroblasts : evidence for receptor antagonism .
8581424	0	cyclooxygenase_and_5-lipoxygenase	67,100	5-lipoxygenase	114,128	cyclooxygenase and 5-lipoxygenase	5-lipoxygenase	240	240	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Hydroxylamine analogs of 2,6-di-t-butylphenols : dual inhibitors of cyclooxygenase_and_5-lipoxygenase or selective 5-lipoxygenase inhibitors .
10216286	0	cyclooxygenases_1_and_2	90,113	epidermal_growth_factor_receptor	36,68	cyclooxygenases 1 and 2	epidermal growth factor receptor	5742;5743	1956	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Growth stimulation and induction of epidermal_growth_factor_receptor by overexpression of cyclooxygenases_1_and_2 in human colon_carcinoma cells .
26553996	0	cyclophilin-D	16,29	HAX-1	0,5	cyclophilin-D	HAX-1	10105	10456	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart .
24668750	0	cyclophilin_A	65,78	CXCR7	80,85	cyclophilin A	CXCR7	268373(Tax:10090)	12778(Tax:10090)	Gene	Gene	ubiquitination|compound|START_ENTITY ubiquitination|dep|END_ENTITY	SDF-1a induces differential trafficking of CXCR4-CXCR7 involving cyclophilin_A , CXCR7 ubiquitination and promotes platelet survival .
21441138	0	cyclophilin_A	31,44	EMMPRIN	15,22	cyclophilin A	EMMPRIN	268373(Tax:10090)	12215(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY reduces|nsubj|interaction Disrupting|parataxis|reduces Disrupting|dobj|END_ENTITY	Disrupting the EMMPRIN -LRB- CD147 -RRB- - cyclophilin_A interaction reduces infarct size and preserves systolic function after myocardial_ischemia and reperfusion .
16275650	0	cyclophilin_A	44,57	Gag	14,17	cyclophilin A	Gag	5478	155030(Tax:11676)	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Altered HIV-1 Gag protein interactions with cyclophilin_A -LRB- CypA -RRB- on the acquisition of H219Q and H219P substitutions in the CypA binding loop .
11830645	0	cyclophilin_A	71,84	Itk	34,37	cyclophilin A	Itk	5478	3702	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin_A .
18829531	0	cyclophilin_A	17,30	Janus-activated_kinase_2	45,69	cyclophilin A	Janus-activated kinase 2	5478	3717	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Prolyl isomerase cyclophilin_A regulation of Janus-activated_kinase_2 and the progression of human breast_cancer .
16596256	0	cyclophilin_A	107,120	RAB24	6,11	cyclophilin A	RAB24	5478	53917	Gene	Gene	colocalized|nmod|START_ENTITY colocalized|nsubjpass|END_ENTITY	Human RAB24 , interestingly and predominantly distributed in the nuclei of COS-7 cells , is colocalized with cyclophilin_A and GABARAP .
8075981	0	cyclophilin_A	22,35	cyclosporin_A	51,64	cyclophilin A	cyclosporin A	5478	1161	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	Crystal structures of cyclophilin_A complexed with cyclosporin_A and N-methyl-4 - -LSB- -LRB- E -RRB- -2 - butenyl -RSB- -4,4 - dimethylthreonine cyclosporin_A .
11323438	0	cyclophilin_B	49,62	Kidney_androgen-regulated_protein	0,33	cyclophilin B	Kidney androgen-regulated protein	19035(Tax:10090)	16483(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Kidney_androgen-regulated_protein interacts with cyclophilin_B and reduces cyclosporine_A-mediated toxicity in proximal tubule cells .
1465572	0	cyclosporin-A	10,23	CsA	25,28	cyclosporin-A	CsA	1161	1161	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of cyclosporin-A -LRB- CsA -RRB- in saliva in children after oral administration of the drug in mixture or in capsule form .
3042442	0	cyclosporin_A	98,111	Granulocyte-macrophage_colony-stimulating_factor	0,48	cyclosporin A	Granulocyte-macrophage colony-stimulating factor	71991(Tax:10090)	12981(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor regulation in murine T cells and its relation to cyclosporin_A .
1967265	0	cyclosporin_A	11,24	IL-2	28,32	cyclosporin A	IL-2	1161	16183(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of cyclosporin_A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic_choriomeningitis_virus .
10663638	0	cyclosporin_A	41,54	P-glycoprotein	10,24	cyclosporin A	P-glycoprotein	1161	5243	Gene	Gene	modulation|nmod|START_ENTITY modulation|nsubj|Effect Effect|nmod|END_ENTITY	Effect of P-glycoprotein modulation with cyclosporin_A on cerebrospinal fluid penetration of doxorubicin in non-human primates .
12673668	0	cyclosporin_A	77,90	P-glycoprotein	51,65	cyclosporin A	P-glycoprotein	71991(Tax:10090)	67078(Tax:10090)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Potentiation of domperidone-induced catalepsy by a P-glycoprotein inhibitor , cyclosporin_A .
8075981	0	cyclosporin_A	51,64	cyclophilin_A	22,35	cyclosporin A	cyclophilin A	1161	5478	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Crystal structures of cyclophilin_A complexed with cyclosporin_A and N-methyl-4 - -LSB- -LRB- E -RRB- -2 - butenyl -RSB- -4,4 - dimethylthreonine cyclosporin_A .
25480326	0	cyclosporin_A	23,36	cyclosporin_A	50,63	cyclosporin A	cyclosporin A	1161	1161	Gene	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	Superior outcome using cyclosporin_A alone versus cyclosporin_A plus methotrexate for post-transplant immunosuppression in children with acute_leukemia undergoing sibling hematopoietic stem cell transplantation .
25480326	0	cyclosporin_A	50,63	cyclosporin_A	23,36	cyclosporin A	cyclosporin A	1161	1161	Gene	Gene	using|nmod|START_ENTITY using|dobj|END_ENTITY	Superior outcome using cyclosporin_A alone versus cyclosporin_A plus methotrexate for post-transplant immunosuppression in children with acute_leukemia undergoing sibling hematopoietic stem cell transplantation .
7545467	0	cyclosporin_A	113,126	granulocyte-macrophage_colony-stimulating_factor	14,62	cyclosporin A	granulocyte-macrophage colony-stimulating factor	1161	1437	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Regulation of granulocyte-macrophage_colony-stimulating_factor and E-selectin expression in endothelial cells by cyclosporin_A and the T-cell transcription factor NFAT .
17220244	0	cyclosporin_a	16,29	breast_cancer_resistance_protein	35,67	cyclosporin a	breast cancer resistance protein	1161	9429	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of cyclosporin_a with breast_cancer_resistance_protein .
2045675	0	cyclosporine_A	24,38	ornithine_decarboxylase	42,65	cyclosporine A	ornithine decarboxylase	71991(Tax:10090)	18263(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Differential effects of cyclosporine_A on ornithine_decarboxylase activity induced by ultraviolet-B and PUVA in mouse skin .
25234269	0	cylindromatosis	35,50	CYLD	52,56	cylindromatosis	CYLD	1540	1540	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel frameshift mutation in the cylindromatosis -LRB- CYLD -RRB- gene in a Chinese family with multiple familial trichoepithelioma .
16230348	0	cylindromatosis	21,36	TRAF6	137,142	cylindromatosis	TRAF6	1540	7189	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The tumor suppressor cylindromatosis -LRB- CYLD -RRB- acts as a negative regulator for toll-like_receptor_2 signaling via negative cross-talk with TRAF6 AND TRAF7 .
25406993	0	cyp-35d1	18,26	nhr-176	0,7	cyp-35d1	nhr-176	184495(Tax:6239)	184496(Tax:6239)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	nhr-176 regulates cyp-35d1 to control hydroxylation-dependent metabolism of thiabendazole in C. _ elegans .
17693615	0	cyp19	73,78	aromatase	62,71	cyp19	aromatase	25147(Tax:10116)	25147(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Three promoters PII , PI.f , and PI.tr direct the expression of aromatase -LRB- cyp19 -RRB- gene in male rat germ cells .
17726668	0	cyp19A1	83,90	cytochrome_P-450_aromatase	55,81	cyp19A1	cytochrome P-450 aromatase	1588	1588	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization and expression profile of the ovarian cytochrome_P-450_aromatase -LRB- cyp19A1 -RRB- gene during thermolabile sex determination in pejerrey , Odontesthes bonariensis .
22659284	0	cyp19a1	40,47	aromatase	49,58	cyp19a1	aromatase	373656(Tax:8355)	373656(Tax:8355)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Brain-specific promoter/exon I.f of the cyp19a1 -LRB- aromatase -RRB- gene in Xenopus_laevis .
19718764	0	cyp19a1b	37,45	brain_aromatase	20,35	cyp19a1b	brain aromatase	60640(Tax:7955)	60640(Tax:7955)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Early regulation of brain_aromatase -LRB- cyp19a1b -RRB- by estrogen receptors during zebrafish development .
11807162	0	cyp3a	14,19	pregnane_x_receptor	46,65	cyp3a	pregnane x receptor	1576	8856	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of cyp3a gene transcription by the pregnane_x_receptor .
21273695	0	cystathionine_b-synthase	54,78	CBS	80,83	cystathionine b-synthase	CBS	875	875	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel alleles of 31-bp VNTR polymorphism in the human cystathionine_b-synthase -LRB- CBS -RRB- gene were detected in healthy Asians .
26803480	0	cystathionine_b-synthase	40,64	CBS	66,69	cystathionine b-synthase	CBS	101703797	101703797	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Low sulfide levels and a high degree of cystathionine_b-synthase -LRB- CBS -RRB- activation by S-adenosylmethionine -LRB- SAM -RRB- in the long-lived naked_mole-rat .
11528503	0	cystathionine_beta-synthase	20,47	CBS	49,52	cystathionine beta-synthase	CBS	875	875	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A 31 bp VNTR in the cystathionine_beta-synthase -LRB- CBS -RRB- gene is associated with reduced CBS activity and elevated post-load homocysteine levels .
8094069	0	cystathionine_beta-synthase	23,50	CBS	52,55	cystathionine beta-synthase	CBS	875	875	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage mapping of the cystathionine_beta-synthase -LRB- CBS -RRB- gene on human chromosome 21 using a DNA polymorphism in the 3 ' untranslated region .
9708897	0	cystathionine_beta-synthase	37,64	CBS	66,69	cystathionine beta-synthase	CBS	875	875	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of a novel deletion in the cystathionine_beta-synthase -LRB- CBS -RRB- gene using an improved genomic DNA based method .
9790750	0	cystathionine_beta-synthase	10,37	CBS	39,42	cystathionine beta-synthase	CBS	875	875	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human cystathionine_beta-synthase -LRB- CBS -RRB- gene : complete sequence , alternative splicing , and polymorphisms .
9466992	0	cystathionine_beta-synthase	26,53	Huntingtin	0,10	cystathionine beta-synthase	Huntingtin	24250(Tax:10116)	29424(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Huntingtin interacts with cystathionine_beta-synthase .
12588964	0	cystathionine_beta_synthase	18,45	CBS	47,50	cystathionine beta synthase	CBS	12411(Tax:10090)	12411(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the cystathionine_beta_synthase -LRB- CBS -RRB- gene during mouse development and immunolocalization in adult brain .
22034194	0	cystathionine_gamma-lyase	28,53	MicroRNA-21	0,11	cystathionine gamma-lyase	MicroRNA-21	1491	406991	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	MicroRNA-21 represses human cystathionine_gamma-lyase expression by targeting at specificity_protein-1 in smooth muscle cells .
21659522	0	cystathionine_gamma-lyase	55,80	Specificity_protein-1	0,21	cystathionine gamma-lyase	Specificity protein-1	1491	6667	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Specificity_protein-1 as a critical regulator of human cystathionine_gamma-lyase in smooth muscle cells .
22360859	0	cystathionine_y-lyase	33,54	Sp1	0,3	cystathionine y-lyase	Sp1	107869(Tax:10090)	6667	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression involved|nmod|regulation involved|nsubjpass|END_ENTITY	Sp1 is involved in regulation of cystathionine_y-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular_carcinoma cell lines .
11673262	0	cystatin-related_epididymal_spermatogenic	64,105	Cres	107,111	cystatin-related epididymal spermatogenic	Cres	13012(Tax:10090)	13012(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	CCAAT/enhancer _ binding_protein beta regulates expression of the cystatin-related_epididymal_spermatogenic -LRB- Cres -RRB- gene .
17486270	0	cystatin-related_epididymal_spermatogenic	32,73	Cres	75,79	cystatin-related epididymal spermatogenic	Cres	13012(Tax:10090)	13012(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Age-dependent expression of the cystatin-related_epididymal_spermatogenic -LRB- Cres -RRB- gene in mouse testis and epididymis .
12586766	0	cystatin-related_epididymal_spermatogenic_protein	4,53	prohormone_convertase_2	83,106	cystatin-related epididymal spermatogenic protein	prohormone convertase 2	13012(Tax:10090)	18549(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The cystatin-related_epididymal_spermatogenic_protein inhibits the serine protease prohormone_convertase_2 .
12423365	0	cystatin_A	72,82	cysteine_protease	43,60	cystatin A	cysteine protease	1475	1508	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The role of the second binding loop of the cysteine_protease inhibitor , cystatin_A -LRB- stefin A -RRB- , in stabilizing complexes with target proteases is exerted predominantly by Leu73 .
10441345	0	cystatin_B	116,126	EPM1	135,139	cystatin B	EPM1	1476	1476	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Altered spacing of promoter elements due to the dodecamer repeat expansion contributes to reduced expression of the cystatin_B gene in EPM1 .
9192856	0	cystatin_B	98,108	EPM1	125,129	cystatin B	EPM1	1476	1476	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	The NNP-1 gene -LRB- D21S2056E -RRB- , which encodes a novel nuclear protein , maps in close proximity to the cystatin_B gene within the EPM1 and APECED critical region on 21q22 .3 .
16137571	0	cystatin_B	38,48	epm1	32,36	cystatin B	epm1	25308(Tax:10116)	25308(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cell-specific expression of the epm1 -LRB- cystatin_B -RRB- gene in developing rat cerebellum .
25288807	0	cystatin_B	21,31	stefin_B	11,19	cystatin B	stefin B	13014(Tax:10090)	13014(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for stefin_B -LRB- cystatin_B -RRB- in inflammation and endotoxemia .
11978599	0	cystatin_C	20,30	Beta-trace_protein	0,18	cystatin C	Beta-trace protein	1471	5730	Gene	Gene	beta|dep|START_ENTITY beta|amod|END_ENTITY	Beta-trace_protein , cystatin_C , beta -LRB- 2 -RRB- - microglobulin , and creatinine compared for detecting impaired glomerular filtration rates in children .
18227369	0	cystatin_C	106,116	Beta2-microglobulin	0,19	cystatin C	Beta2-microglobulin	1471	567	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Beta2-microglobulin for risk stratification of total mortality in the elderly population : comparison with cystatin_C and C-reactive_protein .
22811690	0	cystatin_C	27,37	Beta_2-microglobulin	6,26	cystatin C	Beta 2-microglobulin	1471	567	Gene	Gene	index|amod|START_ENTITY index|dep|END_ENTITY	Serum Beta_2-microglobulin / cystatin_C index : a useful biomarker in lupus_nephritis ?
20157249	0	cystatin_C	29,39	CST3	4,8	cystatin C	CST3	1471	1471	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	The CST3 BB genotype and low cystatin_C cerebrospinal fluid levels are associated with dementia in Lewy_body_disease .
22435454	0	cystatin_C	21,31	CST3	32,36	cystatin C	CST3	1471	1471	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Meta-analysis of the cystatin_C -LRB- CST3 -RRB- gene G73A polymorphism and susceptibility to Alzheimer 's _ disease .
2567273	0	cystatin_C	10,20	CST3	27,31	cystatin C	CST3	1471	1471	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human cystatin_C gene -LRB- CST3 -RRB- , mutated in hereditary cystatin_C amyloid_angiopathy , is located on chromosome 20 .
2764935	0	cystatin_C	10,20	CST3	27,31	cystatin C	CST3	1471	1471	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human cystatin_C gene -LRB- CST3 -RRB- is a member of the cystatin gene family which is localized on chromosome 20 .
8103758	0	cystatin_C	55,65	CST3	72,76	cystatin C	CST3	1471	1471	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An Ala/Thr variation in the coding region of the human cystatin_C gene -LRB- CST3 -RRB- detected as a SstII polymorphism .
20446879	0	cystatin_C	91,101	Cystatin_C	47,57	cystatin C	Cystatin C	1471	1471	Gene	Gene	assay|nmod|START_ENTITY assay|compound|END_ENTITY	Performance evaluation of the Roche Tina-quant Cystatin_C assay and reference interval for cystatin_C in healthy blood donors .
24357805	0	cystatin_C	49,59	Cystatin_SN	0,11	cystatin C	Cystatin SN	1471	1469	Gene	Gene	effect|nmod|START_ENTITY neutralizes|dobj|effect neutralizes|nsubj|END_ENTITY	Cystatin_SN neutralizes the inhibitory effect of cystatin_C on cathepsin_B activity .
25422248	0	cystatin_C	21,31	cathepsin_B	6,17	cystatin C	cathepsin B	1471	1508	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|nmod|ratio	Serum cathepsin_B to cystatin_C ratio as a potential marker for the diagnosis of cholangiocarcinoma .
3517880	0	cystatin_C	128,138	gamma-trace	101,112	cystatin C	gamma-trace	1471	1471	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	Amyloid fibrils in hereditary_cerebral_hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein -LRB- cystatin_C -RRB- .
18461289	0	cystatin_C	79,89	interleukin-6	6,19	cystatin C	interleukin-6	1471	3569	Gene	Gene	correlation|nmod|START_ENTITY correlation|dep|END_ENTITY	Serum interleukin-6 in patients with metastatic bone_disease : correlation with cystatin_C .
26693747	0	cystatin_C	15,25	leptin	31,37	cystatin C	leptin	1471	3952	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of cystatin_C with leptin and TNF-a in elderly Japanese women .
15122877	0	cystatin_C	38,48	neuroglobin	21,32	cystatin C	neuroglobin	1471	58157	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human neuroglobin with cystatin_C , a cysteine_proteinase_inhibitor .
12479412	0	cystatin_C	67,77	proteinase	15,25	cystatin C	proteinase	1471	100616101	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Enhancement of proteinase inhibitory activity of recombinant human cystatin_C using random-centroid optimization .
25677700	0	cystatin_C	35,45	resistin	21,29	cystatin C	resistin	1471	56729	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|nmod|ratio	Association of serum resistin with cystatin_C and urinary albumin-to-creatinine ratio in elderly Chinese men with essential hypertension .
8422752	0	cystatin_D	26,36	CST5	43,47	cystatin D	CST5	1473	1473	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human cystatin_D gene -LRB- CST5 -RRB- to chromosome 20p11 .21 by in situ hybridization .
24261636	0	cystatin_S	70,80	SAP-1	31,36	cystatin S	SAP-1	1472	5794	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|dep|form	Studies on the interactions of SAP-1 -LRB- an N-terminal truncated form of cystatin_S -RRB- with its binding partners by CD-spectroscopic and molecular docking methods .
19463800	0	cystatin_SN	49,60	cysteine_protease	20,37	cystatin SN	cysteine protease	1469	1508	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Upregulation of the cysteine_protease inhibitor , cystatin_SN , contributes to cell proliferation and cathepsin inhibition in gastric_cancer .
21995436	0	cysteine-rich_61	80,96	early_growth_response-1	24,47	cysteine-rich 61	early growth response-1	3491	1958	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cigarette smoke-induced early_growth_response-1 regulates the expression of the cysteine-rich_61 in human skin dermal fibroblasts .
24895995	0	cysteine-rich_61_protein	8,32	CCN1	34,38	cysteine-rich 61 protein	CCN1	3491	3491	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of cysteine-rich_61_protein -LRB- CCN1 -RRB- in macrophage-mediated oncolytic herpes simplex virus clearance .
8833095	0	cysteine-rich_fibroblast_growth_factor_receptor	26,73	CFR	75,78	cysteine-rich fibroblast growth factor receptor	CFR	396492(Tax:9031)	396492(Tax:9031)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the chicken cysteine-rich_fibroblast_growth_factor_receptor -LRB- CFR -RRB- during embryogenesis and retina development .
23570421	0	cysteine-rich_intestinal_protein_1	14,48	CRIP1	50,55	cysteine-rich intestinal protein 1	CRIP1	1396	1396	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	The impact of cysteine-rich_intestinal_protein_1 -LRB- CRIP1 -RRB- in human breast_cancer .
9867350	0	cysteine-rich_protein	16,37	CRP	39,42	cysteine-rich protein	CRP	429786(Tax:9031)	429786(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of a cysteine-rich_protein -LRB- CRP -RRB- encoding gene during early development of the trout .
24037310	0	cysteine-rich_protein_61	21,45	transforming_growth_factor_beta	57,88	cysteine-rich protein 61	transforming growth factor beta	3491	7040	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The up-regulation of cysteine-rich_protein_61 induced by transforming_growth_factor_beta enhances osteosarcoma cell migration .
9020862	0	cysteine-rich_secretory_protein-1	63,96	CRISP-1	98,105	cysteine-rich secretory protein-1	CRISP-1	11571(Tax:10090)	11571(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the androgen-dependent mouse cysteine-rich_secretory_protein-1 -LRB- CRISP-1 -RRB- gene .
22429321	0	cysteine-rich_secretory_protein-1	51,84	mCRISP1	86,93	cysteine-rich secretory protein-1	mCRISP1	11571(Tax:10090)	11571(Tax:10090)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunogenicity study of plasmid DNA encoding mouse cysteine-rich_secretory_protein-1 -LRB- mCRISP1 -RRB- as a contraceptive vaccine .
7639699	0	cysteine-rich_secretory_protein-3	63,96	CRISP-3	98,105	cysteine-rich secretory protein-3	CRISP-3	11572(Tax:10090)	11572(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the androgen-dependent mouse cysteine-rich_secretory_protein-3 -LRB- CRISP-3 -RRB- gene .
18550510	0	cysteine-rich_secretory_protein_2	27,60	CRISP2	62,68	cysteine-rich secretory protein 2	CRISP2	7180	7180	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the human cysteine-rich_secretory_protein_2 -LRB- CRISP2 -RRB- gene in Australian men .
15867000	0	cysteine-rich_secretory_protein_3	37,70	CRISP-3	72,79	cysteine-rich secretory protein 3	CRISP-3	10321	10321	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization and localization of cysteine-rich_secretory_protein_3 -LRB- CRISP-3 -RRB- in the human male reproductive tract .
26785325	0	cysteine_dioxygenase_1	60,82	CDO1	84,88	cysteine dioxygenase 1	CDO1	1036	1036	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	Prognostic Significance of Promoter DNA Hypermethylation of cysteine_dioxygenase_1 -LRB- CDO1 -RRB- Gene in Primary Breast_Cancer .
16436681	0	cysteine_protease	16,33	cathepsin_S	35,46	cysteine protease	cathepsin S	1508	1520	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of cysteine_protease , cathepsin_S , to the surface of vascular smooth muscle cells by association with integrin alphanubeta3 .
12423365	0	cysteine_protease	43,60	cystatin_A	72,82	cysteine protease	cystatin A	1508	1475	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The role of the second binding loop of the cysteine_protease inhibitor , cystatin_A -LRB- stefin A -RRB- , in stabilizing complexes with target proteases is exerted predominantly by Leu73 .
19463800	0	cysteine_protease	20,37	cystatin_SN	49,60	cysteine protease	cystatin SN	1508	1469	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Upregulation of the cysteine_protease inhibitor , cystatin_SN , contributes to cell proliferation and cathepsin inhibition in gastric_cancer .
9662479	0	cysteine_proteinase	51,70	CP1	72,75	cysteine proteinase	CP1	36546(Tax:7227)	36546(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and associated mutational effects of the cysteine_proteinase -LRB- CP1 -RRB- gene of Drosophila_melanogaster .
15991182	0	cysteine_receptor_7	56,75	CCR7	77,81	cysteine receptor 7	CCR7	12775(Tax:10090)	12775(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Murine neuroblastoma attenuates dendritic cell cysteine cysteine_receptor_7 -LRB- CCR7 -RRB- expression .
20641097	0	cysteine_rich_protein_61	28,52	CYR61	54,59	cysteine rich protein 61	CYR61	3491	3491	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Embryonic expression of the cysteine_rich_protein_61 -LRB- CYR61 -RRB- gene : A candidate for the development of human epispadias .
16846449	0	cysteinyl-leukotriene_type-1_receptor	27,64	CYSLTR1	66,73	cysteinyl-leukotriene type-1 receptor	CYSLTR1	10800	10800	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	927T > C polymorphism of the cysteinyl-leukotriene_type-1_receptor -LRB- CYSLTR1 -RRB- gene in children with asthma and atopic_dermatitis .
10862786	0	cystic_fibrosis_transmembrane_conductance_regulator	14,65	AMP-activated_protein_kinase	113,141	cystic fibrosis transmembrane conductance regulator	AMP-activated protein kinase	24255(Tax:10116)	78975(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cystic_fibrosis_transmembrane_conductance_regulator by novel interaction with the metabolic sensor AMP-activated_protein_kinase .
25270793	0	cystic_fibrosis_transmembrane_conductance_regulator	69,120	Aquaporin-9	0,11	cystic fibrosis transmembrane conductance regulator	Aquaporin-9	24255(Tax:10116)	65054(Tax:10116)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic_fibrosis_transmembrane_conductance_regulator .
10869574	0	cystic_fibrosis_transmembrane_conductance_regulator	59,110	Aquaporin_3	0,11	cystic fibrosis transmembrane conductance regulator	Aquaporin 3	373725(Tax:8355)	494589(Tax:8355)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Aquaporin_3 cloned from Xenopus_laevis is regulated by the cystic_fibrosis_transmembrane_conductance_regulator .
20724552	0	cystic_fibrosis_transmembrane_conductance_regulator	8,59	CD3	63,66	cystic fibrosis transmembrane conductance regulator	CD3	12638(Tax:10090)	12501(Tax:10090)	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Lack of cystic_fibrosis_transmembrane_conductance_regulator in CD3 + lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses .
10417323	0	cystic_fibrosis_transmembrane_conductance_regulator	62,113	CFTR	120,124	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of DNase-I-hypersensitive sites at the 3 ' end of the cystic_fibrosis_transmembrane_conductance_regulator gene -LRB- CFTR -RRB- .
10645285	0	cystic_fibrosis_transmembrane_conductance_regulator	18,69	CFTR	71,75	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- mRNA in normal and pathological adult human epididymis .
1283566	0	cystic_fibrosis_transmembrane_conductance_regulator	61,112	CFTR	114,118	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of CA/GT microsatellite polymorphism in IVS8 of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene : a study of Italian CF families .
1284534	0	cystic_fibrosis_transmembrane_conductance_regulator	50,101	CFTR	103,107	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations and sequence variations detected in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene : a report from the Cystic_Fibrosis Genetic Analysis Consortium .
1284540	0	cystic_fibrosis_transmembrane_conductance_regulator	62,113	CFTR	115,119	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of an intron 12 splice donor mutation in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
12939655	0	cystic_fibrosis_transmembrane_conductance_regulator	25,76	CFTR	78,82	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene , the cationic_trypsinogen -LRB- PRSS1 -RRB- gene , and the serine_protease_inhibitor , _ Kazal_type_1 -LRB- SPINK1 -RRB- gene in patients with alcoholic_chronic_pancreatitis .
1370810	0	cystic_fibrosis_transmembrane_conductance_regulator	62,113	CFTR	115,119	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Dinucleotide -LRB- CA/GT -RRB- repeat polymorphism in intron 17B of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
1379670	0	cystic_fibrosis_transmembrane_conductance_regulator	177,228	CFTR	238,242	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Localised mutagenesis of the fts YEX operon : conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia_coli are similar to those found in the cystic_fibrosis_transmembrane_conductance_regulator protein -LRB- CFTR -RRB- of human patients .
1382222	0	cystic_fibrosis_transmembrane_conductance_regulator	103,154	CFTR	156,160	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fluorescence-based , multiplex allele-specific PCR -LRB- MASPCR -RRB- detection of the delta F508 deletion in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
14602047	0	cystic_fibrosis_transmembrane_conductance_regulator	70,121	CFTR	64,68	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR -LRB- cystic_fibrosis_transmembrane_conductance_regulator -RRB- domain .
15286085	0	cystic_fibrosis_transmembrane_conductance_regulator	20,71	CFTR	73,77	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Novel regulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- channel gating by external chloride .
15357566	0	cystic_fibrosis_transmembrane_conductance_regulator	40,91	CFTR	93,97	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel missense mutation A1081P in the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene identified in a Laotian patient with congenital_bilateral_absence_of_the_vas_deferens .
16246030	0	cystic_fibrosis_transmembrane_conductance_regulator	91,142	CFTR	144,148	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Crystallographic and single-particle analyses of native - and nucleotide-bound forms of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- protein .
16481627	0	cystic_fibrosis_transmembrane_conductance_regulator	14,65	CFTR	67,71	cystic fibrosis transmembrane conductance regulator	CFTR	12638(Tax:10090)	12638(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Assessment of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- activity in CFTR-null mice after bone marrow transplantation .
18687795	0	cystic_fibrosis_transmembrane_conductance_regulator	80,131	CFTR	133,137	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Validation of high-resolution DNA melting analysis for mutation scanning of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
19759008	0	cystic_fibrosis_transmembrane_conductance_regulator	119,170	CFTR	172,176	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of a disease-associated mutation affecting a putative splicing regulatory element in intron 6b of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
20483217	0	cystic_fibrosis_transmembrane_conductance_regulator	32,83	CFTR	85,89	cystic fibrosis transmembrane conductance regulator	CFTR	105927055	105927055	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and regulation of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene in killifish : A comparative genomics approach .
20974851	0	cystic_fibrosis_transmembrane_conductance_regulator	14,65	CFTR	67,71	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Modulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- activity and genistein binding by cytosolic pH. Potentiators are molecules that increase the activity of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- .
22131388	0	cystic_fibrosis_transmembrane_conductance_regulator	90,141	CFTR	151,155	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The decline of fertility in male uremic patients is correlated with low expression of the cystic_fibrosis_transmembrane_conductance_regulator protein -LRB- CFTR -RRB- in human sperm .
22186622	0	cystic_fibrosis_transmembrane_conductance_regulator	52,103	CFTR	105,109	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Novel action of the chalcone isoliquiritigenin as a cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- inhibitor : potential therapy for cholera and polycystic_kidney_disease .
22366595	0	cystic_fibrosis_transmembrane_conductance_regulator	18,69	CFTR	71,75	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- is associated with human cervical cancer_malignancy , progression and prognosis .
24782114	0	cystic_fibrosis_transmembrane_conductance_regulator	76,127	CFTR	129,133	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A balance between activating and repressive histone modifications regulates cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- expression in vivo .
25090262	0	cystic_fibrosis_transmembrane_conductance_regulator	20,71	CFTR	73,77	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Predictive value of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- in the diagnosis of gastric_cancer .
7540587	0	cystic_fibrosis_transmembrane_conductance_regulator	65,116	CFTR	118,122	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Three novel sequence variations in the 5 ' upstream region of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene : two polymorphisms and one putative molecular defect .
8163293	0	cystic_fibrosis_transmembrane_conductance_regulator	47,98	CFTR	100,104	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new missense mutation G126D in exon 4 of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
8428507	0	cystic_fibrosis_transmembrane_conductance_regulator	50,101	CFTR	103,107	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fluorescence in situ hybridization mapping of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene to 7q31 .3 .
8629807	0	cystic_fibrosis_transmembrane_conductance_regulator	112,163	CFTR	165,169	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Diagnostic usefulness of the polymorphism of the GT dinucleotide and the polythymidine tract in intron 8 of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- gene .
9346929	0	cystic_fibrosis_transmembrane_conductance_regulator	101,152	CFTR	95,99	cystic fibrosis transmembrane conductance regulator	CFTR	1080	1080	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	ATP depletion induces a loss of respiratory epithelium functional integrity and down-regulates CFTR -LRB- cystic_fibrosis_transmembrane_conductance_regulator -RRB- expression .
19098309	0	cystic_fibrosis_transmembrane_conductance_regulator	64,115	Cysteine_string_protein	0,23	cystic fibrosis transmembrane conductance regulator	Cysteine string protein	1080	80331	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Cysteine_string_protein promotes proteasomal degradation of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation .
16954204	0	cystic_fibrosis_transmembrane_conductance_regulator	51,102	Derlin-1	0,8	cystic fibrosis transmembrane conductance regulator	Derlin-1	1080	79139	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Derlin-1 promotes the efficient degradation of the cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- and CFTR folding mutants .
10893422	0	cystic_fibrosis_transmembrane_conductance_regulator	71,122	E3KARP	0,6	cystic fibrosis transmembrane conductance regulator	E3KARP	1080	9351	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	E3KARP mediates the association of ezrin and protein kinase A with the cystic_fibrosis_transmembrane_conductance_regulator in airway cells .
16799633	0	cystic_fibrosis_transmembrane_conductance_regulator	32,83	MUC4	0,4	cystic fibrosis transmembrane conductance regulator	MUC4	1080	4585	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	MUC4 expression is regulated by cystic_fibrosis_transmembrane_conductance_regulator in pancreatic_adenocarcinoma cells via transcriptional and post-translational mechanisms .
20826815	0	cystic_fibrosis_transmembrane_conductance_regulator	21,72	Syntaxin_16	0,11	cystic fibrosis transmembrane conductance regulator	Syntaxin 16	24255(Tax:10116)	362283(Tax:10116)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Syntaxin_16 binds to cystic_fibrosis_transmembrane_conductance_regulator and regulates its membrane trafficking in epithelial cells .
10206998	0	cystic_fibrosis_transmembrane_conductance_regulator	4,55	aquaporin_3	66,77	cystic fibrosis transmembrane conductance regulator	aquaporin 3	1080	360	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The cystic_fibrosis_transmembrane_conductance_regulator activates aquaporin_3 in airway epithelial cells .
16051699	0	cystic_fibrosis_transmembrane_conductance_regulator	27,78	interferon_gamma	82,98	cystic fibrosis transmembrane conductance regulator	interferon gamma	1080	3458	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of cystic_fibrosis_transmembrane_conductance_regulator by interferon_gamma in mast cells and epithelial cells .
22520513	0	cystic_fibrosis_transmembrane_conductance_regulator	22,73	mGluR1	0,6	cystic fibrosis transmembrane conductance regulator	mGluR1	1080	14799(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	mGluR1 interacts with cystic_fibrosis_transmembrane_conductance_regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes .
11937500	0	cystic_fibrosis_transmembrane_conductance_regulator	60,111	protein_kinase_A	11,27	cystic fibrosis transmembrane conductance regulator	protein kinase A	24255(Tax:10116)	25636(Tax:10116)	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Reciprocal protein_kinase_A regulatory interactions between cystic_fibrosis_transmembrane_conductance_regulator and Na + / H + exchanger isoform 3 in a renal polarized epithelial cell model .
1281385	0	cystic_fibrosis_transmembrane_regulator	25,64	CFTR	66,70	cystic fibrosis transmembrane regulator	CFTR	1080	1080	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Ethnic heterogeneity and cystic_fibrosis_transmembrane_regulator -LRB- CFTR -RRB- mutation frequencies in Chicago-area CF families .
9482579	0	cystic_fibrosis_transmembrane_regulator	41,80	CFTR	82,86	cystic fibrosis transmembrane regulator	CFTR	1080	1080	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of five novel mutations of the cystic_fibrosis_transmembrane_regulator -LRB- CFTR -RRB- gene in Pakistani patients with cystic_fibrosis : Y569D , Q98X , 296 +12 -LRB- T > C -RRB- , 1161delC and 621 +2 -LRB- T > C -RRB- .
16919623	0	cystinyl_aminopeptidase	49,72	AT4_receptor	12,24	cystinyl aminopeptidase	AT4 receptor	4012	4012	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Angiotensin AT4_receptor ligand interaction with cystinyl_aminopeptidase and aminopeptidase_N : -LSB- 125I -RSB- Angiotensin_IV only binds to the cystinyl_aminopeptidase apo-enzyme .
25796504	0	cyt_c	58,63	cytochrome_c	44,56	TRAIL	cytochrome c	8743	54205	Gene	Gene	release|dep|START_ENTITY release|amod|END_ENTITY	Cisplatin-mediated c-myc overexpression and cytochrome_c -LRB- cyt_c -RRB- release result in the up-regulation of the death receptors DR4 and DR5 and the activation of caspase_3 and caspase_9 , likely responsible for the TRAIL-sensitizing effect of cisplatin .
23538781	0	cytb	19,23	Cytochrome_b	0,12	cytb	Cytochrome b	4519	4519	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cytochrome_b gene -LRB- cytb -RRB- sequence diversity in a Microtus oeconomus population from Bialowieza Primeval Forest .
12788029	0	cytb	113,117	cytochrome_b	94,106	cytb	cytochrome b	2655541(Tax:5833)	2655541(Tax:5833)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Detection of atovaquone and Malarone resistance conferring mutations in Plasmodium_falciparum cytochrome_b gene -LRB- cytb -RRB- .
16580072	0	cytidine_deaminase	29,47	AID	76,79	cytidine deaminase	AID	978	57379	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	HIV-1 Vif protein blocks the cytidine_deaminase activity of B-cell specific AID in E. _ coli by a similar mechanism of action .
20010457	0	cytidine_deaminase	63,81	CDA	88,91	cytidine deaminase	CDA	978	978	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High-resolution melting analysis of sequence variations in the cytidine_deaminase gene -LRB- CDA -RRB- in patients with cancer treated with gemcitabine .
23612254	0	cytidine_deaminase	44,62	CDA	64,67	cytidine deaminase	CDA	978	978	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Determination of common genetic variants in cytidine_deaminase -LRB- CDA -RRB- gene in Indian ethnic population .
9450474	0	cytochrome-P450_1A1	27,46	MTHFR	103,108	cytochrome-P450 1A1	MTHFR	1543	4524	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Germ line polymorphisms in cytochrome-P450_1A1 -LRB- C4887 CYP1A1 -RRB- and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- genes and endometrial_cancer susceptibility .
18992370	0	cytochrome-c	34,46	Bax	21,24	cytochrome-c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Putative partners in Bax mediated cytochrome-c release : ANT , CypD , VDAC or none of them ?
16740732	0	cytochrome_B	38,50	CD4	0,3	cytochrome B	CD4	4519	920	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	CD4 + T-cell response to mitochondrial cytochrome_B in human melanoma .
1492386	0	cytochrome_B5	46,59	menadione_reductase	13,32	cytochrome B5	menadione reductase	64001(Tax:10116)	24314(Tax:10116)	Gene	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	-LSB- Activity of menadione_reductase and level of cytochrome_B5 and P-450 in liver with varying supplies of vitamin_K and administration of pelentan to rats -RSB- .
18722181	0	cytochrome_C	64,76	Bax	0,3	cytochrome C	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY uncoupled|nmod|release uncoupled|nsubjpass|fission fission|amod|END_ENTITY	Bax - or Bak-induced mitochondrial fission can be uncoupled from cytochrome_C release .
14739607	0	cytochrome_C	73,85	Bcl-2	57,62	cytochrome C	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY roles|nmod|release END_ENTITY|dep|roles	Apoptosis modulatory activities of transiently expressed Bcl-2 : roles in cytochrome_C release and Bax regulation .
14966123	0	cytochrome_C	29,41	Bcl-2	69,74	cytochrome C	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY signals|nmod|release induced|nsubj|signals induced|nmod|inhibitor inhibitor|compound|END_ENTITY	Critical upstream signals of cytochrome_C release induced by a novel Bcl-2 inhibitor .
19267995	0	cytochrome_C	23,35	Peroxidase	0,10	cytochrome C	Peroxidase	34995(Tax:7227)	2768671(Tax:7227)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Peroxidase activity of cytochrome_C facilitates the protoporphyrinogen_oxidase reaction .
11029754	0	cytochrome_C	118,130	bax	23,26	cytochrome C	bax	54205	581	Gene	Gene	release|amod|START_ENTITY promotes|dobj|release fragment|acl:relcl|promotes generates|dobj|fragment generates|nsubj|cleavage cleavage|nmod|END_ENTITY	N-terminal cleavage of bax by calpain generates a potent proapoptotic 18-kDa fragment that promotes bcl-2-independent cytochrome_C release and apoptotic cell death .
19674236	0	cytochrome_C_oxidase_subunit_I	17,47	COI	49,52	cytochrome C oxidase subunit I	COI	19893533	248139	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequences of the cytochrome_C_oxidase_subunit_I -LRB- COI -RRB- gene are suitable for species identification of Korean Calliphorinae flies of forensic importance -LRB- Diptera : Calliphoridae -RRB- .
11868391	0	cytochrome_P-450	15,31	CYP	33,36	cytochrome P-450	CYP	4051	4051	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	-LSB- Regulation of cytochrome_P-450 -LRB- CYP -RRB- genes by nuclear receptors -RSB- .
1643634	0	cytochrome_P-450	8,24	CYP3A	40,45	cytochrome P-450	CYP3A	4051	1576	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Role of cytochrome_P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes .
2121542	0	cytochrome_P-450	14,30	CYPIA1	31,37	cytochrome P-450	CYPIA1	13079(Tax:10090)	13076(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Regulation of cytochrome_P-450 CYPIA1 gene expression and proto-oncogene expression by growth factors in primary hepatocytes .
3418515	0	cytochrome_P-450	22,38	P-450j	59,65	cytochrome P-450	P-450j	25251(Tax:10116)	25086(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|dep|role role|nmod|END_ENTITY	Pyridine induction of cytochrome_P-450 in the rat : role of P-450j -LRB- alcohol-inducible form -RRB- in pyridine_N-oxidation .
11340572	0	cytochrome_P-450	50,66	SRD5A2	113,119	cytochrome P-450	SRD5A2	1586	6716	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Impact of genetic polymorphisms of 17-hydroxylase cytochrome_P-450 -LRB- CYP17 -RRB- and steroid_5alpha-reductase_type_II -LRB- SRD5A2 -RRB- genes on prostate-cancer risk among the Japanese population .
2510717	0	cytochrome_P-450	88,104	cholesterol_7_alpha-hydroxylase	14,45	cytochrome P-450	cholesterol 7 alpha-hydroxylase	25251(Tax:10116)	25428(Tax:10116)	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|nmod|form	Inhibition of cholesterol_7_alpha-hydroxylase by an antibody to a male-specific form of cytochrome_P-450 from subfamily P450IIC .
3918791	0	cytochrome_P-450	36,52	cytochrome_P-450_reductase	109,135	cytochrome P-450	cytochrome P-450 reductase	25251(Tax:10116)	29441(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Immunohistochemical localization of cytochrome_P-450 and reduced_nicotinamide_adenine_dinucleotide_phosphate : cytochrome_P-450_reductase in the rat ventral prostate .
7390994	0	cytochrome_P-450	89,105	cytochrome_b5	129,142	cytochrome P-450	cytochrome b5	100328948(Tax:9986)	100328915(Tax:9986)	Gene	Gene	START_ENTITY|nmod|affinity affinity|nmod|END_ENTITY	NADH - and NADPH-dependent reconstituted p-nitroanisole_O-demethylation system containing cytochrome_P-450 with high affinity for cytochrome_b5 .
1630156	0	cytochrome_P-4503A	8,26	CYP3A	28,33	cytochrome P-4503A	CYP3A	1576	1576	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Hepatic cytochrome_P-4503A -LRB- CYP3A -RRB- activity in the elderly .
3494447	0	cytochrome_P-450_15_beta	49,73	Growth_hormone	0,14	cytochrome P-450 15 beta	Growth hormone	25011(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Growth_hormone regulates expression of rat liver cytochrome_P-450_15_beta at a pretranslational level .
16762476	0	cytochrome_P-450_1A2	47,67	hCYP1A2	69,76	cytochrome P-450 1A2	hCYP1A2	1544	1544	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Apiaceous vegetable constituents inhibit human cytochrome_P-450_1A2 -LRB- hCYP1A2 -RRB- activity and hCYP1A2-mediated mutagenicity of aflatoxin_B1 .
1346350	0	cytochrome_P-450_21-hydroxylase	70,101	CYP21	103,108	cytochrome P-450 21-hydroxylase	CYP21	1589	1589	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Rapid identification of deoxyribonucleic acid sequence differences in cytochrome_P-450_21-hydroxylase -LRB- CYP21 -RRB- genes with denaturing gradient gel blots .
10490907	0	cytochrome_P-450_2E1	12,32	CYP2E1	34,40	cytochrome P-450 2E1	CYP2E1	1571	1571	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Duration of cytochrome_P-450_2E1 -LRB- CYP2E1 -RRB- inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans .
11939710	0	cytochrome_P-450_2E1	31,51	CYP2E1	53,59	cytochrome P-450 2E1	CYP2E1	25086(Tax:10116)	25086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of methacrylonitrile on cytochrome_P-450_2E1 -LRB- CYP2E1 -RRB- expression in male F344 rats .
17726668	0	cytochrome_P-450_aromatase	55,81	cyp19A1	83,90	cytochrome P-450 aromatase	cyp19A1	1588	1588	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization and expression profile of the ovarian cytochrome_P-450_aromatase -LRB- cyp19A1 -RRB- gene during thermolabile sex determination in pejerrey , Odontesthes bonariensis .
1391968	0	cytochrome_P-450_nifedipine_oxidase	24,59	CYP3A4	66,72	cytochrome P-450 nifedipine oxidase	CYP3A4	1576	1576	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human cytochrome_P-450_nifedipine_oxidase gene -LRB- CYP3A4 -RRB- to chromosome 7 at band q22 .1 by fluorescence in situ hybridization .
3918791	0	cytochrome_P-450_reductase	109,135	cytochrome_P-450	36,52	cytochrome P-450 reductase	cytochrome P-450	29441(Tax:10116)	25251(Tax:10116)	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of cytochrome_P-450 and reduced_nicotinamide_adenine_dinucleotide_phosphate : cytochrome_P-450_reductase in the rat ventral prostate .
3415695	0	cytochrome_P-450j	29,46	growth_hormone	11,25	cytochrome P-450j	growth hormone	25086(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone on cytochrome_P-450j .
1991523	0	cytochrome_P-450scc	15,34	cytochrome_b5	40,53	cytochrome P-450scc	cytochrome b5	338048(Tax:9913)	281110(Tax:9913)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cytochrome_P-450scc with cytochrome_b5 .
8617372	0	cytochrome_P-45OIIC18	24,45	CYP2C18	47,54	cytochrome P-45OIIC18	CYP2C18	1562	1562	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic analysis of the cytochrome_P-45OIIC18 -LRB- CYP2C18 -RRB- gene and a novel member of the CYP2C subfamily .
7980651	0	cytochrome_P450	23,38	2B1/2	39,44	cytochrome P450	2B1/2	25251(Tax:10116)	286954(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Biphasic regulation of cytochrome_P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel .
12389869	0	cytochrome_P450	53,68	CYP	70,73	cytochrome P450	CYP	4051	4051	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of xenobiotic-metabolizing cytochrome_P450 -LRB- CYP -RRB- enzymes in human lung .
15128046	0	cytochrome_P450	14,29	CYP	31,34	cytochrome P450	CYP	13079(Tax:10090)	13079(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Comparison of cytochrome_P450 -LRB- CYP -RRB- genes from the mouse and human genomes , including nomenclature recommendations for genes , pseudogenes and alternative-splice variants .
12130549	0	cytochrome_P450	112,127	CYP19	129,134	cytochrome P450	CYP19	1588	1588	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ligands for the peroxisomal_proliferator-activated_receptor_gamma and the retinoid_X_receptor inhibit aromatase cytochrome_P450 -LRB- CYP19 -RRB- expression mediated by promoter II in human breast adipose .
8808317	0	cytochrome_P450	77,92	CYP19	94,99	cytochrome P450	CYP19	1588	1588	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Quantitative detection of alternatively spliced transcripts of the aromatase cytochrome_P450 -LRB- CYP19 -RRB- gene in aromatase-expressing human cells by competitive RT-PCR .
8923826	0	cytochrome_P450	54,69	CYP19	71,76	cytochrome P450	CYP19	1588	1588	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Use of alternative promoters to express the aromatase cytochrome_P450 -LRB- CYP19 -RRB- gene in breast adipose tissues of cancer-free_and_breast_cancer patients .
8989235	0	cytochrome_P450	51,66	CYP19	68,73	cytochrome P450	CYP19	1588	1588	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternatively spliced transcripts of the aromatase cytochrome_P450 -LRB- CYP19 -RRB- gene in adipose tissue of women .
12870655	0	cytochrome_P450	24,39	CYP1B1	93,99	cytochrome P450	CYP1B1	4051	1545	Gene	Gene	genes|amod|START_ENTITY profiling|nmod|genes profiling|dep|upregulation upregulation|nmod|END_ENTITY	Transcript profiling of cytochrome_P450 genes in HL-60 human leukemic cells : upregulation of CYP1B1 by all-trans-retinoic_acid .
11454912	0	cytochrome_P450	87,102	CYP3A	126,131	cytochrome P450	CYP3A	4051	1576	Gene	Gene	enzymes|amod|START_ENTITY interaction|nmod|enzymes metabolism|nmod|interaction metabolism|dep|role role|nmod|END_ENTITY	Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome_P450 enzymes : major role of CYP3A .
15159443	0	cytochrome_P450	80,95	CYP3A	133,138	cytochrome P450	CYP3A	4051	1576	Gene	Gene	system|amod|START_ENTITY biotransformation|nmod|system evaluation|nmod|biotransformation evaluation|dep|roles roles|nmod|END_ENTITY	Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome_P450 system in vitro : prominent roles for CYP3A and CYP2D6 .
21890735	0	cytochrome_P450	54,69	CYP3A	94,99	cytochrome P450	CYP3A	4051	1576	Gene	Gene	activity|amod|START_ENTITY Proluciferin_acetals|nmod|activity Proluciferin_acetals|nmod|inhibition inhibition|compound|END_ENTITY	Proluciferin_acetals as bioluminogenic substrates for cytochrome_P450 activity and probes for CYP3A inhibition .
23491640	0	cytochrome_P450	33,48	CYP3A	66,71	cytochrome P450	CYP3A	4051	1576	Gene	Gene	enzymes|amod|START_ENTITY expression|nmod|enzymes expression|nmod|subfamily subfamily|compound|END_ENTITY	Differential expression of human cytochrome_P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls .
9574808	0	cytochrome_P450	53,68	CYP3A	69,74	cytochrome P450	CYP3A	25251(Tax:10116)	170509(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Ethylmorphine N-demethylase activity as a marker for cytochrome_P450 CYP3A activity in rat hepatic microsomes .
8597156	0	cytochrome_P450	45,60	CYP3A7	14,20	cytochrome P450	CYP3A7	4051	1551	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CYP3A7 , a human fetus-specific cytochrome_P450 , in cultured cells and in the hepatocytes of p53-knockout mice .
8995791	0	cytochrome_P450	44,59	CYP6A2	66,72	cytochrome P450	CYP6A2	35587(Tax:7227)	35587(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inducibility of the Drosophila_melanogaster cytochrome_P450 gene , CYP6A2 , by phenobarbital in insecticide susceptible or resistant strains .
8033136	0	cytochrome_P450	9,24	Cyp1b1	26,32	cytochrome P450	Cyp1b1	13079(Tax:10090)	13078(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Enhanced cytochrome_P450 -LRB- Cyp1b1 -RRB- expression , aryl_hydrocarbon hydroxylase activity , cytotoxicity , and transformation of C3H 10T1/2 cells by dimethylbenz -LRB- a -RRB- anthracene in conditioned medium .
16713132	0	cytochrome_P450	17,32	Cyp6a2	40,46	cytochrome P450	Cyp6a2	45282(Tax:7227)	35587(Tax:7227)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Induction of two cytochrome_P450 genes , Cyp6a2 and Cyp6a8 , of Drosophila_melanogaster by caffeine in adult flies and in cell culture .
1874173	0	cytochrome_P450	55,70	Interleukin-1	0,13	cytochrome P450	Interleukin-1	4051	3552	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-1 inhibits cholesterol side-chain cleavage cytochrome_P450 expression in primary cultures of Leydig cells .
17014963	0	cytochrome_P450	25,40	Nitric-oxide_synthase	0,21	cytochrome P450	Nitric-oxide synthase	4051	4843	Gene	Gene	family|amod|START_ENTITY END_ENTITY|dep|family	Nitric-oxide_synthase : a cytochrome_P450 family foster child .
18930820	0	cytochrome_P450	51,66	P450_reductase	0,14	cytochrome P450	P450 reductase	35635(Tax:7227)	33883(Tax:7227)	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	P450_reductase and cytochrome_b5 interactions with cytochrome_P450 : effects on house fly CYP6A1 catalysis .
11891538	0	cytochrome_P450	68,83	PC_3	109,113	cytochrome P450	PC 3	4051	57332	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin induces cytochrome_P450 activity in high passage PC_3 and DU 145 human prostate_cancer cell lines .
10375402	0	cytochrome_P450	28,43	Phospholipase_D	0,15	cytochrome P450	Phospholipase D	4051	2822	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Phospholipase_D activity of cytochrome_P450 in human liver endoplasmic reticulum .
1321814	0	cytochrome_P450	30,45	cytochrome_P450	4,19	cytochrome P450	cytochrome P450	4051	4051	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	The cytochrome_P450 2B4-NADPH cytochrome_P450 reductase electron transfer complex is not formed by charge-pairing .
1321814	0	cytochrome_P450	4,19	cytochrome_P450	30,45	cytochrome P450	cytochrome P450	4051	4051	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	The cytochrome_P450 2B4-NADPH cytochrome_P450 reductase electron transfer complex is not formed by charge-pairing .
8723734	0	cytochrome_P450	28,43	epidermal_growth_factor_receptor	63,95	cytochrome P450	epidermal growth factor receptor	25251(Tax:10116)	24329(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of constitutive cytochrome_P450 gene expression by epidermal_growth_factor_receptor ligands in cultured rat hepatocytes .
10877000	0	cytochrome_P450	46,61	transforming_growth_factor-beta1	10,42	cytochrome P450	transforming growth factor-beta1	25251(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of transforming_growth_factor-beta1 on cytochrome_P450 expression : inhibition of CYP1 mRNA and protein expression in primary rat hepatocytes .
15072980	0	cytochrome_P4501A1	38,56	CYP1A1	58,64	cytochrome P4501A1	CYP1A1	24296(Tax:10116)	24296(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Respirable coal_dust particles modify cytochrome_P4501A1 -LRB- CYP1A1 -RRB- expression in rat alveolar cells .
8202380	0	cytochrome_P4501A1	129,147	CYP1A1	149,155	cytochrome P4501A1	CYP1A1	1543	1543	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aryl_hydrocarbon-induced interactions at multiple DNA elements of diverse sequence -- a multicomponent mechanism for activation of cytochrome_P4501A1 -LRB- CYP1A1 -RRB- gene transcription .
9874250	0	cytochrome_P4501A1	33,51	CYP1A1	53,59	cytochrome P4501A1	CYP1A1	1543	1543	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional analysis of the human cytochrome_P4501A1 -LRB- CYP1A1 -RRB- gene enhancer .
9028875	0	cytochrome_P4501A2	73,91	CYP1A2	93,99	cytochrome P4501A2	CYP1A2	1544	1544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of positive and negative regulatory elements of the human cytochrome_P4501A2 -LRB- CYP1A2 -RRB- gene .
10511040	0	cytochrome_P4501B1	31,49	CYP1B1	51,57	cytochrome P4501B1	CYP1B1	1545	1545	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel truncating mutation of cytochrome_P4501B1 -LRB- CYP1B1 -RRB- gene in primary infantile_glaucoma .
15359218	0	cytochrome_P4501b1	14,32	Cyp1b1	34,40	cytochrome P4501b1	Cyp1b1	13078(Tax:10090)	13078(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cytochrome_P4501b1 -LRB- Cyp1b1 -RRB- during early murine development .
18287571	0	cytochrome_P4502B6	75,93	CYP2B6	95,101	cytochrome P4502B6	CYP2B6	1555	1555	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome_P4502B6 -LRB- CYP2B6 -RRB- activity .
9263374	0	cytochrome_P4502C19	83,102	CYP2C19	104,111	cytochrome P4502C19	CYP2C19	1557	1557	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Single-dose pharmacokinetics and pharmacodynamics of oral triazolam in relation to cytochrome_P4502C19 -LRB- CYP2C19 -RRB- activity .
20206639	0	cytochrome_P4502C19	42,61	GATA-4	25,31	cytochrome P4502C19	GATA-4	1557	2626	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The transcription factor GATA-4 regulates cytochrome_P4502C19 gene expression .
7733969	0	cytochrome_P4502D	49,66	CYP2D16	68,75	cytochrome P4502D	CYP2D16	100169696(Tax:10141)	100169696(Tax:10141)	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Molecular cloning and sequencing of a guinea_pig cytochrome_P4502D -LRB- CYP2D16 -RRB- : high level expression in adrenal microsomes .
1389951	0	cytochrome_P4502D6	58,76	CYP2D6	78,84	cytochrome P4502D6	CYP2D6	1565	1565	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effect of selective serotonin re-uptake inhibitors on cytochrome_P4502D6 -LRB- CYP2D6 -RRB- activity in human liver microsomes .
15768052	0	cytochrome_P4502D6	72,90	CYP2D6	92,98	cytochrome P4502D6	CYP2D6	1565	1565	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of novel sequence variations in the cytochrome_P4502D6 -LRB- CYP2D6 -RRB- gene in African Americans .
15585372	0	cytochrome_P4502E1	14,32	CYP2E1	34,40	cytochrome P4502E1	CYP2E1	1571	1571	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Comparison of cytochrome_P4502E1 -LRB- CYP2E1 -RRB- activity and hepatic and lymphocyte mRNA expression in patients with chronic hepatitis_C .
20100563	0	cytochrome_P4502E1	33,51	CYP2E1	53,59	cytochrome P4502E1	CYP2E1	1571	1571	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Genetic polymorphism analysis of cytochrome_P4502E1 -LRB- CYP2E1 -RRB- in Chinese Han populations from four different geographic areas of Mainland China .
7786308	0	cytochrome_P4502E1	17,35	CYP2E1	37,43	cytochrome P4502E1	CYP2E1	25086(Tax:10116)	25086(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Rapid changes in cytochrome_P4502E1 -LRB- CYP2E1 -RRB- activity and other P450 isozymes following ethanol withdrawal in rats .
9538127	0	cytochrome_P4502E1	27,45	CYP2E1	47,53	cytochrome P4502E1	CYP2E1	25086(Tax:10116)	25086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of cytochrome_P4502E1 -LRB- CYP2E1 -RRB- in Morris_hepatomas and livers of tumor bearing rats .
19225389	0	cytochrome_P4503A	46,63	CYP3A	65,70	cytochrome P4503A	CYP3A	1576	1576	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Methadone pharmacokinetics are independent of cytochrome_P4503A -LRB- CYP3A -RRB- activity and gastrointestinal drug transport : insights from methadone interactions with ritonavir/indinavir .
19232844	0	cytochrome_P4503A	83,100	CYP3A	102,107	cytochrome P4503A	CYP3A	1576	1576	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome_P4503A -LRB- CYP3A -RRB- activity .
12048211	0	cytochrome_P450C24	87,105	CYP24	107,112	cytochrome P450C24	CYP24	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Role of MAP kinases in the 1,25-dihydroxyvitamin _ D3-induced transactivation of the rat cytochrome_P450C24 -LRB- CYP24 -RRB- promoter .
15836435	0	cytochrome_P450C24	92,110	CYP24	112,117	cytochrome P450C24	CYP24	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Molecular action of 1,25-dihydroxyvitamin _ D3 and phorbol_ester on the activation of the rat cytochrome_P450C24 -LRB- CYP24 -RRB- promoter : role of MAP kinase activities and identification of an important transcription factor binding site .
8085941	0	cytochrome_P450IA1	56,74	Transforming_growth_factor-beta_1	0,33	cytochrome P450IA1	Transforming growth factor-beta 1	1543	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits TCDD-induced cytochrome_P450IA1 expression in human lung_cancer A549 cells .
8179586	0	cytochrome_P450IA2	51,69	CYP1A2	71,77	cytochrome P450IA2	CYP1A2	24297(Tax:10116)	24297(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ionic lead , a unique metal ion as an inhibitor for cytochrome_P450IA2 -LRB- CYP1A2 -RRB- expression in the rat liver .
7915935	0	cytochrome_P450IIE1	62,81	CYP2E1	54,60	cytochrome P450IIE1	CYP2E1	1571	1571	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Restriction fragment length polymorphism of the human CYP2E1 -LRB- cytochrome_P450IIE1 -RRB- gene and susceptibility to lung_cancer : possible relevance to low smoking exposure .
7992014	1	cytochrome_P450IIE1_and_catalase	116,148	alcohol_dehydrogenase	93,114	cytochrome P450IIE1 and catalase	alcohol dehydrogenase	847	10327	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	I. Metabolism of ethanol by alcohol_dehydrogenase , cytochrome_P450IIE1_and_catalase -RSB- .
11023996	0	cytochrome_P450RAI	21,39	CYP26	14,19	cytochrome P450RAI	CYP26	13082(Tax:10090)	13082(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Regulation of CYP26 -LRB- cytochrome_P450RAI -RRB- mRNA expression and retinoic_acid metabolism by retinoids and dietary vitamin_A in liver of mice and rats .
9826557	0	cytochrome_P450RAI	14,32	CYP26	34,39	cytochrome P450RAI	CYP26	1592	1592	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cytochrome_P450RAI -LRB- CYP26 -RRB- in human fetal hepatic and cephalic tissues .
15178024	0	cytochrome_P450_1A	11,29	CYP1A	31,36	cytochrome P450 1A	CYP1A	100125806(Tax:8090)	100125806(Tax:8090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Cloning of cytochrome_P450_1A -LRB- CYP1A -RRB- genes from the hermaphrodite fish Rivulus_marmoratus and the Japanese_medaka Oryzias_latipes .
23178197	0	cytochrome_P450_1A	37,55	CYP1A	57,62	cytochrome P450 1A	CYP1A	100125806(Tax:8090)	100125806(Tax:8090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of biomarker potential of cytochrome_P450_1A -LRB- CYP1A -RRB- gene in the marine medaka , Oryzias melastigma exposed to water-accommodated_fractions -LRB- WAFs -RRB- of Iranian crude oil .
20035380	0	cytochrome_P450_1A1	22,41	CYP1A1	43,49	cytochrome P450 1A1	CYP1A1	1543	1543	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Four polymorphisms in cytochrome_P450_1A1 -LRB- CYP1A1 -RRB- gene and breast_cancer risk : a meta-analysis .
10889552	0	cytochrome_P450_1A2	33,52	CYP1A2	54,60	cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A functional polymorphism of the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene : association with tardive_dyskinesia in schizophrenia .
11496364	0	cytochrome_P450_1A2	61,80	CYP1A2	82,88	cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between a functional polymorphism of the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene and tardive_dyskinesia in schizophrenia .
15564895	0	cytochrome_P450_1A2	64,83	CYP1A2	85,91	cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic association analysis of functional polymorphisms in the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene with tardive_dyskinesia in Japanese patients with schizophrenia .
16261361	0	cytochrome_P450_1A2	55,74	CYP1A2	76,82	cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Artemisinin and thiabendazole are potent inhibitors of cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity in humans .
17611010	0	cytochrome_P450_1A2	32,51	CYP1A2	53,59	cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms of the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene and prolonged_QTc_interval in schizophrenia .
25081684	0	cytochrome_P450_1A2	26,45	CYP1A2	47,53	cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Four polymorphisms in the cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- gene and lung_cancer risk : a meta-analysis .
25442272	0	cytochrome_P450_1A2	65,84	CYP1A2	86,92	cytochrome P450 1A2	CYP1A2	1544	1544	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	In vitro effect of important herbal active constituents on human cytochrome_P450_1A2 -LRB- CYP1A2 -RRB- activity .
15177283	0	cytochrome_P450_1A2	31,50	HDJ-1	99,104	cytochrome P450 1A2	HDJ-1	1544	3337	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	High-level expression of human cytochrome_P450_1A2 by co-expression with human molecular chaperone HDJ-1 -LRB- Hsp40 -RRB- .
15451558	0	cytochrome_P450_1A2	29,48	Hsp70	97,102	cytochrome P450 1A2	Hsp70	1544	3308	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of human cytochrome_P450_1A2 by co-expression with human molecular chaperone Hsp70 .
12372064	0	cytochrome_P450_1B1	43,62	CYP1B1	64,70	cytochrome P450 1B1	CYP1B1	1545	1545	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel frameshift founder mutation in the cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- gene is associated with primary congenital_glaucoma in Morocco .
16319821	0	cytochrome_P450_1B1	59,78	CYP1B1	80,86	cytochrome P450 1B1	CYP1B1	1545	1545	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a common coding polymorphism -LRB- N453S -RRB- of the cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- gene with optic disc cupping and visual field alteration in French patients with primary_open-angle_glaucoma .
20054638	0	cytochrome_P450_1B1	23,42	CYP1B1	44,50	cytochrome P450 1B1	CYP1B1	1545	1545	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Three polymorphisms in cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- gene and breast_cancer risk : a meta-analysis .
9525272	0	cytochrome_P450_1B1	30,49	CYP1B1	51,57	cytochrome P450 1B1	CYP1B1	1545	1545	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Induction and localization of cytochrome_P450_1B1 -LRB- CYP1B1 -RRB- protein in the livers of TCDD-treated rats : detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria .
11159795	0	cytochrome_P450_2A6	29,48	CYP2A6	50,56	cytochrome P450 2A6	CYP2A6	1548	1548	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms in the cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- gene : implications for interindividual differences in nicotine metabolism .
20402563	0	cytochrome_P450_2A6	57,76	CYP2A6	78,84	cytochrome P450 2A6	CYP2A6	1548	1548	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	In vitro modulation of naturally occurring flavonoids on cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- activity .
9682269	0	cytochrome_P450_2A6	34,53	CYP2A6	55,61	cytochrome P450 2A6	CYP2A6	1548	1548	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new deleted allele in the human cytochrome_P450_2A6 -LRB- CYP2A6 -RRB- gene found in individuals showing poor metabolic capacity to coumarin and -LRB- + -RRB- - cis-3 ,5 - dimethyl-2 - -LRB- 3-pyridyl -RRB- thiazolidin-4-one_hydrochloride -LRB- SM-12502 -RRB- .
15617513	0	cytochrome_P450_2B1	63,82	CYP2B1	84,90	cytochrome P450 2B1	CYP2B1	24300(Tax:10116)	24300(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Regulatory sequence responsible for insulin destabilization of cytochrome_P450_2B1 -LRB- CYP2B1 -RRB- mRNA .
18303024	0	cytochrome_P450_2B6	76,95	early_growth_response_1	30,53	cytochrome P450 2B6	early growth response 1	1555	1958	Gene	Gene	gene|amod|START_ENTITY activate|dobj|gene END_ENTITY|xcomp|activate	Nuclear receptor CAR requires early_growth_response_1 to activate the human cytochrome_P450_2B6 gene .
16641871	0	cytochrome_P450_2C19	15,35	CYP2C19	37,44	cytochrome P450 2C19	CYP2C19	1557	1557	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differences in cytochrome_P450_2C19 -LRB- CYP2C19 -RRB- expression in adjacent normal and tumor tissues in Chinese cancer patients .
10424320	0	cytochrome_P450_2C19	173,193	cytochrome_P450_2D6	135,154	cytochrome P450 2C19	cytochrome P450 2D6	1557	1565	Gene	Gene	debrisoquine|appos|START_ENTITY debrisoquine|appos|END_ENTITY	Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine -LRB- cytochrome_P450_2D6 -RRB- and mephenytoin -LRB- cytochrome_P450_2C19 -RRB- .
10773015	0	cytochrome_P450_2C9	37,56	CYP2C9	58,64	cytochrome P450 2C9	CYP2C9	1559	1559	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Major role of human liver microsomal cytochrome_P450_2C9 -LRB- CYP2C9 -RRB- in the oxidative metabolism of celecoxib , a novel cyclooxygenase-II inhibitor .
10807974	0	cytochrome_P450_2D6	4,23	CYP2D6	25,31	cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- gene polymorphism among breast and head_and_neck_cancer patients .
11037801	0	cytochrome_P450_2D6	8,27	CYP2D6	29,35	cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- in the stereospecific metabolism of E - and Z-doxepin .
16192683	0	cytochrome_P450_2D6	17,36	CYP2D6	38,44	cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Determination of cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- gene copy number by real-time quantitative PCR .
16808005	0	cytochrome_P450_2D6	53,72	CYP2D6	74,80	cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Mechanism-based inhibition of human liver microsomal cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by alkamides of Piper nigrum .
17270484	0	cytochrome_P450_2D6	115,134	CYP2D6	136,142	cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of catechol-0-methyltransferase -LRB- COMT -RRB- , monoamine_oxidase_B -LRB- MAOB -RRB- , N-acetyltransferase_2 -LRB- NAT2 -RRB- and cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- gene in patients with early onset of Parkinson 's _ disease .
8448065	0	cytochrome_P450_2D6	20,39	CYP2D6	41,47	cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of human cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- by methadone .
8941025	0	cytochrome_P450_2D6	4,23	CYP2D6	25,31	cytochrome P450 2D6	CYP2D6	1565	1565	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The cytochrome_P450_2D6 -LRB- CYP2D6 -RRB- enzyme polymorphism : screening costs and influence on clinical outcomes in psychiatry .
10424320	0	cytochrome_P450_2D6	135,154	cytochrome_P450_2C19	173,193	cytochrome P450 2D6	cytochrome P450 2C19	1565	1557	Gene	Gene	debrisoquine|appos|START_ENTITY debrisoquine|appos|END_ENTITY	Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine -LRB- cytochrome_P450_2D6 -RRB- and mephenytoin -LRB- cytochrome_P450_2C19 -RRB- .
22668639	0	cytochrome_P450_2E1	17,36	CYP2E1	38,44	cytochrome P450 2E1	CYP2E1	13106(Tax:10090)	13106(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of cytochrome_P450_2E1 -LRB- CYP2E1 -RRB- in the development of high fat-induced non-alcoholic_steatohepatitis .
17440116	0	cytochrome_P450_2E1	14,33	TonEBP	71,77	cytochrome P450 2E1	TonEBP	1571	10725	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cytochrome_P450_2E1 under hypertonic environment through TonEBP in human hepatocytes .
20364586	0	cytochrome_P450_2E1	46,65	aldehyde_dehydrogenase-2	21,45	cytochrome P450 2E1	aldehyde dehydrogenase-2	1571	217	Gene	Gene	polymorphism|amod|START_ENTITY Association|dep|polymorphism Association|nmod|END_ENTITY	-LSB- Association between aldehyde_dehydrogenase-2 / cytochrome_P450_2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular_carcinoma -RSB- .
14566010	0	cytochrome_P450_2E1	15,34	interferon-gamma	56,72	cytochrome P450 2E1	interferon-gamma	1571	3458	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Suppression of cytochrome_P450_2E1 promoter activity by interferon-gamma and loss of response due to the -71 G > T nucleotide polymorphism of the CYP2E1 * 7B allele .
8352886	0	cytochrome_P450_2a-5	19,39	coumarin_7-hydroxylase	41,63	cytochrome P450 2a-5	coumarin 7-hydroxylase	13087(Tax:10090)	13087(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	High expression of cytochrome_P450_2a-5 -LRB- coumarin_7-hydroxylase -RRB- in mouse hepatomas .
10230766	0	cytochrome_P450_3A	10,28	CYP3A	30,35	cytochrome P450 3A	CYP3A	13112(Tax:10090)	13112(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Unchanged cytochrome_P450_3A -LRB- CYP3A -RRB- expression and metabolism of midazolam , triazolam , and dexamethasone in mdr -LRB- - / - -RRB- mouse liver microsomes .
12951492	0	cytochrome_P450_3A	39,57	CYP3A	59,64	cytochrome P450 3A	CYP3A	1576	1576	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibitory effects of citrus fruits on cytochrome_P450_3A -LRB- CYP3A -RRB- activity in humans .
15342613	0	cytochrome_P450_3A	33,51	CYP3A	53,58	cytochrome P450 3A	CYP3A	1576	1576	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effects of modifying in vivo cytochrome_P450_3A -LRB- CYP3A -RRB- activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity .
11753266	0	cytochrome_P450_3A4	83,102	CYP3A4	104,110	cytochrome P450 3A4	CYP3A4	1576	1576	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- activity in humans .
23295386	0	cytochrome_P450_3A4	51,70	CYP3A4	72,78	cytochrome P450 3A4	CYP3A4	1576	1576	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Direct transcriptional regulation of human hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARa -RRB- .
21480191	0	cytochrome_P450_3A4	119,138	P-glycoprotein	139,153	cytochrome P450 3A4	P-glycoprotein	1576	5243	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Novel evidence-based colchicine dose-reduction algorithm to predict and prevent colchicine_toxicity in the presence of cytochrome_P450_3A4 / P-glycoprotein inhibitors .
20538049	0	cytochrome_P450_3A4	78,97	Pregnane_X_receptor	0,19	cytochrome P450 3A4	Pregnane X receptor	1576	8856	Gene	Gene	down-regulation|nmod|START_ENTITY required|nmod|down-regulation required|nsubjpass|END_ENTITY	Pregnane_X_receptor is required for interleukin-6-mediated down-regulation of cytochrome_P450_3A4 in human hepatocytes .
23295386	0	cytochrome_P450_3A4	51,70	peroxisome_proliferator-activated_receptor_alpha	83,131	cytochrome P450 3A4	peroxisome proliferator-activated receptor alpha	1576	5465	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Direct transcriptional regulation of human hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARa -RRB- .
17003103	0	cytochrome_P450_3A4	54,73	pregnane_X_receptor	135,154	cytochrome P450 3A4	pregnane X receptor	1576	8856	Gene	Gene	evidence|amod|START_ENTITY induces|dobj|evidence induces|nmod|involvement involvement|nmod|END_ENTITY	Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome_P450_3A4 and carboxylesterase HCE2 : evidence on an involvement of the pregnane_X_receptor .
18268015	0	cytochrome_P450_3A4	100,119	pregnane_X_receptor	41,60	cytochrome P450 3A4	pregnane X receptor	1576	8856	Gene	Gene	expression|nmod|START_ENTITY affects|dobj|expression affects|nsubj|regulation regulation|nmod|END_ENTITY	Post-transcriptional regulation of human pregnane_X_receptor by micro-RNA affects the expression of cytochrome_P450_3A4 .
20504912	0	cytochrome_P450_3A4	24,43	pregnane_X_receptor	90,109	cytochrome P450 3A4	pregnane X receptor	1576	8856	Gene	Gene	induction|amod|START_ENTITY attenuates|dobj|induction attenuates|advcl|blocking blocking|dobj|activation activation|nmod|END_ENTITY	Camptothecin attenuates cytochrome_P450_3A4 induction by blocking the activation of human pregnane_X_receptor .
21117944	0	cytochrome_P450_3A4	60,79	pregnane_X_receptor	20,39	cytochrome P450 3A4	pregnane X receptor	1576	8856	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of human pregnane_X_receptor and its target gene cytochrome_P450_3A4 by Chinese herbal compounds and a molecular docking study .
22363234	0	cytochrome_P450_3A4	40,59	pregnane_X_receptor	131,150	cytochrome P450 3A4	pregnane X receptor	1576	8856	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
23707768	0	cytochrome_P450_3A4	73,92	pregnane_X_receptor	25,44	cytochrome P450 3A4	pregnane X receptor	1576	8856	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression END_ENTITY|acl|induce	Piperine activates human pregnane_X_receptor to induce the expression of cytochrome_P450_3A4 and multidrug_resistance_protein_1 .
14695544	0	cytochrome_P450_3A43	46,66	CYP3A43	68,75	cytochrome P450 3A43	CYP3A43	64816	64816	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	First report of a genetic polymorphism of the cytochrome_P450_3A43 -LRB- CYP3A43 -RRB- gene : identification of a loss-of-function variant .
21528942	0	cytochrome_P450_3A5	13,32	CYP3A5	34,40	cytochrome P450 3A5	CYP3A5	1577	1577	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Influence of cytochrome_P450_3A5 -LRB- CYP3A5 -RRB- genetic polymorphism on the pharmacokinetics of the prolonged-release , once-daily formulation of tacrolimus in stable renal transplant recipients .
11284050	0	cytochrome_P450_3a25	77,97	Cyp3a25	99,106	cytochrome P450 3a25	Cyp3a25	56388(Tax:10090)	56388(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Cloning , sequencing , heterologous expression , and characterization of murine cytochrome_P450_3a25 * -LRB- Cyp3a25 -RRB- , a testosterone 6beta-hydroxylase .
15163554	0	cytochrome_P450_4F12	77,97	CYP4F12	99,106	cytochrome P450 4F12	CYP4F12	66002	66002	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Functional characterization of genetic polymorphisms identified in the human cytochrome_P450_4F12 -LRB- CYP4F12 -RRB- promoter region .
12384299	0	cytochrome_P450_4F5	40,59	CYP4F5	61,67	cytochrome P450 4F5	CYP4F5	286905(Tax:10116)	286905(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of the rat cytochrome_P450_4F5 -LRB- CYP4F5 -RRB- gene .
15609124	0	cytochrome_P450_c17alpha	49,73	CYP17	75,80	cytochrome P450 c17alpha	CYP17	1586	1586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the T27C polymorphism in the cytochrome_P450_c17alpha -LRB- CYP17 -RRB- gene and risk factors for breast_cancer .
25569847	0	cytochrome_P450_isoform_356A1	55,84	CYP356A1	86,94	cytochrome P450 isoform 356A1	CYP356A1	105348415	105348415	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Expression and immunohistochemical localization of the cytochrome_P450_isoform_356A1 -LRB- CYP356A1 -RRB- in oyster Crassostrea_gigas .
25038863	0	cytochrome_P450_reductase	43,68	CPR	70,73	cytochrome P450 reductase	CPR	5447	5447	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Molecular population genetics of the NADPH cytochrome_P450_reductase -LRB- CPR -RRB- gene in Anopheles minimus .
22001251	0	cytochrome_P450arom	85,104	CYP19	106,111	cytochrome P450arom	CYP19	1588	1588	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Halowax 1051 affects steroidogenesis , 17b-hydroxysteroid dehydrogenase -LRB- 17b-HSD -RRB- and cytochrome_P450arom -LRB- CYP19 -RRB- activity , and protein expression in porcine ovarian follicles .
2766930	0	cytochrome_P450c	31,47	CYP1A1	49,55	cytochrome P450c	CYP1A1	24296(Tax:10116)	24296(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Transient superinducibility of cytochrome_P450c -LRB- CYP1A1 -RRB- mRNA and transcription .
7629254	0	cytochrome_P450c17	74,92	CYP17	94,99	cytochrome P450c17	CYP17	1586	1586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Seventeen_alpha-hydroxylase_deficiency with one base pair deletion of the cytochrome_P450c17 -LRB- CYP17 -RRB- gene .
9250356	0	cytochrome_P450c17	21,39	CYP17	41,46	cytochrome P450c17	CYP17	1586	1586	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A new variant of the cytochrome_P450c17 -LRB- CYP17 -RRB- gene mutation in three patients with 17 alpha-hydroxylase_deficiency .
11341336	0	cytochrome_P450c17alpha	33,56	CYP17	58,63	cytochrome P450c17alpha	CYP17	1586	1586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common promotor variant in the cytochrome_P450c17alpha -LRB- CYP17 -RRB- gene is associated with bioavailability testosterone levels and bone size in men .
14995917	0	cytochrome_P450c17alpha	23,46	CYP17	53,58	cytochrome P450c17alpha	CYP17	1586	1586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A possible role of the cytochrome_P450c17alpha gene -LRB- CYP17 -RRB- polymorphism in the pathobiology of uterine leiomyomas from black_South African women : a pilot study .
8026494	0	cytochrome_P450scc	92,110	CYP11A1	112,119	cytochrome P450scc	CYP11A1	1583	1583	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulatory mechanisms of cAMP-dependent and cell-specific expression of human steroidogenic cytochrome_P450scc -LRB- CYP11A1 -RRB- gene .
10634913	0	cytochrome_b	66,78	ClpP	23,27	cytochrome b	ClpP	801484(Tax:3055)	2717015(Tax:3055)	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	Evidence for a role of ClpP in the degradation of the chloroplast cytochrome_b -LRB- 6 -RRB- f complex .
12069545	0	cytochrome_b	141,153	IRBP	100,104	cytochrome b	IRBP	4519	5949	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Phylogeny of the genus Apodemus with a special emphasis on the subgenus Sylvaemus using the nuclear IRBP gene and two mitochondrial markers : cytochrome_b and 12S rRNA .
12788029	0	cytochrome_b	94,106	cytb	113,117	cytochrome b	cytb	2655541(Tax:5833)	2655541(Tax:5833)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of atovaquone and Malarone resistance conferring mutations in Plasmodium_falciparum cytochrome_b gene -LRB- cytb -RRB- .
7390994	0	cytochrome_b5	129,142	cytochrome_P-450	89,105	cytochrome b5	cytochrome P-450	100328915(Tax:9986)	100328948(Tax:9986)	Gene	Gene	affinity|nmod|START_ENTITY END_ENTITY|nmod|affinity	NADH - and NADPH-dependent reconstituted p-nitroanisole_O-demethylation system containing cytochrome_P-450 with high affinity for cytochrome_b5 .
1991523	0	cytochrome_b5	40,53	cytochrome_P-450scc	15,34	cytochrome b5	cytochrome P-450scc	281110(Tax:9913)	338048(Tax:9913)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cytochrome_P-450scc with cytochrome_b5 .
11003619	0	cytochrome_c	83,95	Apaf-1	127,133	cytochrome c	Apaf-1	54205	78963(Tax:10116)	Gene	Gene	release|amod|START_ENTITY cells|nmod|release apoptosis|nmod|cells apoptosis|nmod|complex complex|amod|END_ENTITY	Transforming_growth_factor-beta -LRB- 1 -RRB- induces apoptosis in rat FaO hepatoma cells via cytochrome_c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex .
11516099	0	cytochrome_c	89,101	Apaf-1	187,193	cytochrome c	Apaf-1	54205	317	Gene	Gene	release|amod|START_ENTITY release|acl|accompanied accompanied|nmod|formation formation|nmod|END_ENTITY	Proteasome inhibitor-induced apoptosis of B-chronic_lymphocytic_leukaemia cells involves cytochrome_c release and caspase activation , accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex .
15703181	0	cytochrome_c	72,84	Apaf-1	51,57	cytochrome c	Apaf-1	54205	317	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome_c .
16650876	0	cytochrome_c	58,70	Apaf-1	71,77	cytochrome c	Apaf-1	54205	317	Gene	Gene	ratio|dep|START_ENTITY ratio|compound|END_ENTITY	A mathematical model for apoptosome assembly : the optimal cytochrome_c / Apaf-1 ratio .
26014357	0	cytochrome_c	32,44	Apaf-1	67,73	cytochrome c	Apaf-1	54205	317	Gene	Gene	Modeling|nmod|START_ENTITY Modeling|nmod|END_ENTITY	Modeling of interaction between cytochrome_c and the WD domains of Apaf-1 : bifurcated salt bridges underlying apoptosome assembly .
26543158	0	cytochrome_c	49,61	Apaf-1	95,101	cytochrome c	Apaf-1	54205	317	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Atomic structure of the apoptosome : mechanism of cytochrome_c - and dATP-mediated activation of Apaf-1 .
19664589	0	cytochrome_c	25,37	BAX	83,86	cytochrome c	BAX	54205	581	Gene	Gene	release|amod|START_ENTITY mechanisms|nmod|release induced|nsubj|mechanisms induced|nmod|END_ENTITY	Dissimilar mechanisms of cytochrome_c release induced by octyl_glucoside-activated BAX and by BAX activated with truncated BID .
12729577	0	cytochrome_c	14,26	BCL-2	51,56	cytochrome c	BCL-2	54205	596	Gene	Gene	release|amod|START_ENTITY Mechanisms|nmod|release Mechanisms|nmod|members members|compound|END_ENTITY	Mechanisms of cytochrome_c release by proapoptotic BCL-2 family members .
10085289	0	cytochrome_c	74,86	Bax	37,40	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY responsible|nmod|release responsible|nsubj|change change|nmod|END_ENTITY	Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome_c release during apoptosis .
10514382	0	cytochrome_c	11,23	Bax	25,28	cytochrome c	Bax	54205	581	Gene	Gene	migration|amod|START_ENTITY migration|amod|END_ENTITY	Release of cytochrome_c , Bax migration , Bid cleavage , and activation of caspases 2 , 3 , 6 , 7 , 8 , and 9 during endothelial cell apoptosis .
10557088	0	cytochrome_c	67,79	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY precedes|dobj|release insertion|parataxis|precedes insertion|nsubj|membrane membrane|compound|END_ENTITY	Bax membrane insertion during Fas -LRB- CD95 -RRB- - induced apoptosis precedes cytochrome_c release and is inhibited by Bcl-2 .
10620504	0	cytochrome_c	89,101	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY trigger|dobj|release liposomes|acl|trigger required|nmod|liposomes required|nsubjpass|oligomerization oligomerization|compound|END_ENTITY	Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome_c release from mitochondria .
10717243	0	cytochrome_c	28,40	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|overexpression overexpression|compound|END_ENTITY	Bax overexpression enhances cytochrome_c release from mitochondria and sensitizes KATOIII gastric_cancer cells to chemotherapeutic agent-induced apoptosis .
10896657	1	cytochrome_c	137,149	Bax	65,68	cytochrome c	Bax	54205	581	Gene	Gene	release|nmod|START_ENTITY prevents|dobj|release degrees|acl:relcl|prevents insertion|nmod|degrees insertion|nsubj|Failure Failure|nmod|END_ENTITY	Failure of Bax insertion into mitochondria at 15 degrees C prevents the release of cytochrome_c .
11123425	0	cytochrome_c	60,72	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY cascade|nmod|release activates|dobj|cascade activates|nsubj|induction induction|compound|END_ENTITY	Bax induction activates apoptotic cascade via mitochondrial cytochrome_c release and Bax overexpression enhances apoptosis induced by chemotherapeutic agents in DLD-1 colon_cancer cells .
11281652	0	cytochrome_c	39,51	Bax	82,85	cytochrome c	Bax	54205	581	Gene	Gene	translocation|amod|START_ENTITY release|nmod|translocation release|nmod|END_ENTITY	Caspase-dependent cytosolic release of cytochrome_c and membrane translocation of Bax in p53-induced apoptosis .
12243190	0	cytochrome_c	13,25	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	preferentially|amod|START_ENTITY releases|dobj|preferentially releases|nsubj|END_ENTITY	Bax releases cytochrome_c preferentially from a complex between porin and adenine_nucleotide translocator .
14521400	0	cytochrome_c	81,93	Bax	106,109	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	3,6-dibromocarbazole _ piperazine derivatives of 2-propanol as first inhibitors of cytochrome_c release via Bax channel modulation .
15772159	0	cytochrome_c	46,58	Bax	11,14	cytochrome c	Bax	54205	581	Gene	Gene	MAC|amod|START_ENTITY component|nmod|MAC component|nsubj|END_ENTITY	Oligomeric Bax is a component of the putative cytochrome_c release channel MAC , mitochondrial apoptosis-induced channel .
17170750	0	cytochrome_c	78,90	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|nmod|START_ENTITY cooperate|nmod|release cooperate|nsubj|END_ENTITY	Bax and the mitochondrial permeability transition cooperate in the release of cytochrome_c during endoplasmic reticulum-stress-induced apoptosis .
17172466	0	cytochrome_c	102,114	Bax	74,77	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY induce|dobj|release activate|xcomp|induce activate|dobj|END_ENTITY	Reactive oxygen species and p38_mitogen-activated_protein_kinase activate Bax to induce mitochondrial cytochrome_c release and apoptosis in response to malonate .
17689609	0	cytochrome_c	11,23	Bax	51,54	cytochrome c	Bax	54205	581	Gene	Gene	Release|nmod|START_ENTITY precedes|nsubj|Release precedes|dobj|translocation/activation translocation/activation|compound|END_ENTITY	Release of cytochrome_c from mitochondria precedes Bax translocation/activation in Triton_X-100-induced apoptosis .
18546202	0	cytochrome_c	41,53	Bax	22,25	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY translocation|appos|release translocation|compound|END_ENTITY	Detailing the role of Bax translocation , cytochrome_c release , and perinuclear clustering of the mitochondria in the killing of HeLa cells by TNF .
18840646	0	cytochrome_c	25,37	Bax	62,65	cytochrome c	Bax	54205	581	Gene	Gene	wave|nmod|START_ENTITY propagates|nsubj|wave propagates|dobj|redistribution redistribution|compound|END_ENTITY	An intracellular wave of cytochrome_c propagates and precedes Bax redistribution during apoptosis .
18931364	0	cytochrome_c	107,119	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|nmod|START_ENTITY apoptosis|nmod|release bring|dobj|apoptosis act|xcomp|bring act|nsubj|END_ENTITY	Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome_c and subsequent caspase activation .
20304286	0	cytochrome_c	5,17	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	staining|dep|START_ENTITY END_ENTITY|amod|staining	Bax , cytochrome_c , and caspase-8 staining in parotid_cancer patients : markers of susceptibility in radiotherapy ?
21196320	0	cytochrome_c	90,102	Bax	68,71	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY mediated|dobj|release mediated|nsubj|+ +|compound|END_ENTITY	The respiratory-dependent assembly of ANT1 differentially regulates Bax and Ca2 + mediated cytochrome_c release .
21712378	0	cytochrome_c	149,161	Bax	93,96	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY initiate|dobj|release induces|advcl|initiate induces|dobj|oligomerization oligomerization|compound|END_ENTITY	Resveratrol induces p53-independent , X-linked_inhibitor_of_apoptosis_protein -LRB- XIAP -RRB- - mediated Bax protein oligomerization on mitochondria to initiate cytochrome_c release and caspase activation .
22479585	0	cytochrome_c	53,65	Bax	20,23	cytochrome c	Bax	54205	581	Gene	Gene	release|xcomp|START_ENTITY compensated|xcomp|release compensated|nmod|END_ENTITY	Bak compensated for Bax in p53-null cells to release cytochrome_c for the initiation of mitochondrial signaling during Withanolide_D-induced apoptosis .
23536162	0	cytochrome_c	12,24	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Bax induces cytochrome_c release by multiple mechanisms in mitochondria from MCF7 cells .
25275009	0	cytochrome_c	66,78	Bax	45,48	cytochrome c	Bax	54205	581	Gene	Gene	release|amod|START_ENTITY promotes|dobj|release promotes|nsubj|Activation Activation|nmod|OMA1 OMA1|nmod|END_ENTITY	Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome_c release during apoptosis .
9560217	0	cytochrome_c	32,44	Bax	0,3	cytochrome c	Bax	54205	581	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Bax directly induces release of cytochrome_c from isolated mitochondria .
10021389	0	cytochrome_c	55,67	Bcl-2	0,5	cytochrome c	Bcl-2	54205	596	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Bcl-2 regulates amplification of caspase activation by cytochrome_c .
10409669	0	cytochrome_c	58,70	Bcl-2	32,37	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|nmod|START_ENTITY promotes|dobj|release promotes|nsubj|cleavage cleavage|nmod|END_ENTITY	Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome_c .
10462033	0	cytochrome_c	31,43	Bcl-2	130,135	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|nmod|START_ENTITY epitope|nsubj|release epitope|parataxis|prevent prevent|nsubj|END_ENTITY	Early release of mitochondrial cytochrome_c and expression of mitochondrial epitope 7A6 with a porphyrin-derived photosensitizer : Bcl-2 and Bcl-xL overexpression do not prevent early mitochondrial events but still depress caspase activity .
10639121	0	cytochrome_c	50,62	Bcl-2	22,27	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY induce|dobj|release END_ENTITY|dep|induce	Proapoptotic BH3-only Bcl-2 family members induce cytochrome_c release , but not mitochondrial membrane potential loss , and do not directly modulate voltage-dependent anion channel activity .
10760520	0	cytochrome_c	26,38	Bcl-2	11,16	cytochrome c	Bcl-2	54205	596	Gene	Gene	redistribution|amod|START_ENTITY block|dobj|redistribution Failure|acl|block Failure|nmod|END_ENTITY	Failure of Bcl-2 to block cytochrome_c redistribution during TRAIL-induced apoptosis .
11085742	0	cytochrome_c	20,32	Bcl-2	61,66	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY regulated|nsubjpass|release regulated|nmod|bid bid|compound|END_ENTITY	Granzyme_B-mediated cytochrome_c release is regulated by the Bcl-2 family members bid and Bax .
11489892	0	cytochrome_c	91,103	Bcl-2	138,143	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY release|nmod|cells cells|acl:relcl|overexpress overexpress|xcomp|END_ENTITY	Unreliability of the cytochrome_c-enhanced green fluorescent fusion protein as a marker of cytochrome_c release in cells that overexpress Bcl-2 .
12951029	0	cytochrome_c	41,53	Bcl-2	0,5	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|overexpression overexpression|compound|END_ENTITY	Bcl-2 and Bcl-xL overexpression inhibits cytochrome_c release , activation of multiple caspases , and virus release following coxsackievirus B3 infection .
17283155	0	cytochrome_c	125,137	Bcl-2	0,5	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY independent|nmod|release pathway|acl:relcl|independent gamma-radiation|nmod|pathway protects|nmod|gamma-radiation protects|nsubj|END_ENTITY	Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome_c release .
9027314	0	cytochrome_c	45,57	Bcl-2	27,32	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|nmod|START_ENTITY apoptosis|dep|release apoptosis|nmod|END_ENTITY	Prevention of apoptosis by Bcl-2 : release of cytochrome_c from mitochondria blocked .
9027315	0	cytochrome_c	15,27	Bcl-2	66,71	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|nmod|START_ENTITY release|dep|site site|nmod|regulation regulation|compound|END_ENTITY	The release of cytochrome_c from mitochondria : a primary site for Bcl-2 regulation of apoptosis .
9268320	0	cytochrome_c	66,78	Bcl-2	0,5	cytochrome c	Bcl-2	54205	596	Gene	Gene	inactivation|nmod|START_ENTITY membrane|nmod|inactivation membrane|nsubj|END_ENTITY	Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome_c during Fas-mediated apoptosis .
9461218	0	cytochrome_c	58,70	Bcl-2	0,5	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|nmod|START_ENTITY prolongs|nmod|release prolongs|nsubj|END_ENTITY	Bcl-2 prolongs cell survival after Bax-induced release of cytochrome_c .
9694346	0	cytochrome_c	71,83	Bcl-2	132,137	cytochrome c	Bcl-2	54205	596	Gene	Gene	release|amod|START_ENTITY release|nmod|absence absence|nmod|expression expression|nmod|proteins proteins|compound|END_ENTITY	Potassium deprivation-induced apoptosis of cerebellar granule neurons : cytochrome_c release in the absence of altered expression of Bcl-2 family proteins .
10913120	0	cytochrome_c	16,28	Bcl-xL	0,6	cytochrome c	Bcl-xL	54205	598	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Bcl-xL inhibits cytochrome_c release but not mitochondrial depolarization during the activation of multiple death pathways by tumor_necrosis_factor-alpha .
10973993	0	cytochrome_c	80,92	Bid	59,62	cytochrome c	Bid	54205	637	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Preservation of mitochondrial structure and function after Bid - or Bax-mediated cytochrome_c release .
10777619	0	cytochrome_c	125,137	CREB	41,45	cytochrome c	CREB	54205	1385	Gene	Gene	induction|nmod|START_ENTITY leads|nmod|induction leads|nsubj|activation activation|nmod|END_ENTITY	Sequential serum-dependent activation of CREB and NRF-1 leads to enhanced mitochondrial respiration through the induction of cytochrome_c .
11737208	0	cytochrome_c	13,25	Cytochrome_c	0,12	cytochrome c	Cytochrome c	54205	54205	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Cytochrome_c / cytochrome_c oxidase interaction .
12393561	0	cytochrome_c	59,71	Granulocyte_colony-stimulating_factor	0,37	cytochrome c	Granulocyte colony-stimulating factor	54205	1440	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor inhibits spontaneous cytochrome_c release and mitochondria-dependent apoptosis of myelodysplastic_syndrome hematopoietic progenitors .
15649417	0	cytochrome_c	41,53	Hsp27	0,5	cytochrome c	Hsp27	54205	24471(Tax:10116)	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Hsp27 inhibits 6-hydroxydopamine-induced cytochrome_c release and apoptosis in PC12 cells .
18172320	0	cytochrome_c	110,122	SMAC	0,4	cytochrome c	SMAC	54205	56616	Gene	Gene	release|amod|START_ENTITY promoting|dobj|release sensitize|advcl|promoting mimetics|xcomp|sensitize mimetics|nsubj|END_ENTITY	SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome_c release .
15064710	0	cytochrome_c	13,25	Smac	0,4	cytochrome c	Smac	54205	56616	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Smac induces cytochrome_c release and apoptosis independently from Bax/Bcl-x -LRB- L -RRB- in a strictly caspase-3-dependent manner in human carcinoma cells .
15670574	0	cytochrome_c	81,93	c-Jun_N-terminal_kinase	112,135	cytochrome c	c-Jun N-terminal kinase	54205	5599	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Acetoxycycloheximide -LRB- E-73 -RRB- rapidly induces apoptosis mediated by the release of cytochrome_c via activation of c-Jun_N-terminal_kinase .
11901173	0	cytochrome_c	12,24	caspase	28,35	cytochrome c	caspase	34996(Tax:7227)	37729(Tax:7227)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	The role of cytochrome_c in caspase activation in Drosophila_melanogaster cells .
10393962	0	cytochrome_c	39,51	caspase-3	88,97	cytochrome c	caspase-3	54205	836	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Apoptosis in heart_failure : release of cytochrome_c from mitochondria and activation of caspase-3 in human cardiomyopathy .
10822279	0	cytochrome_c	233,245	caspase-3	140,149	cytochrome c	caspase-3	54205	836	Gene	Gene	release|amod|START_ENTITY amplification|nmod|release loop|nmod|amplification END_ENTITY|dep|loop	Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3 : a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome_c release .
10915781	0	cytochrome_c	105,117	caspase-3	136,145	cytochrome c	caspase-3	54205	836	Gene	Gene	efflux|nmod|START_ENTITY efflux|nmod|END_ENTITY	Autocrine gastrins in colon_cancer cells Up-regulate cytochrome_c oxidase Vb and down-regulate efflux of cytochrome_c and activation of caspase-3 .
10915781	0	cytochrome_c	53,65	caspase-3	136,145	cytochrome c	caspase-3	54205	836	Gene	Gene	cells|amod|START_ENTITY gastrins|nmod|cells oxidase|nsubj|gastrins oxidase|dobj|efflux efflux|nmod|END_ENTITY	Autocrine gastrins in colon_cancer cells Up-regulate cytochrome_c oxidase Vb and down-regulate efflux of cytochrome_c and activation of caspase-3 .
11274139	0	cytochrome_c	69,81	caspase-3	121,130	cytochrome c	caspase-3	54205	836	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	The small heat_shock protein alpha B-crystallin negatively regulates cytochrome_c - and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation .
11503418	0	cytochrome_c	36,48	caspase-3	64,73	cytochrome c	caspase-3	54205	836	Gene	Gene	START_ENTITY|appos|activation activation|nmod|deoxyguanosine deoxyguanosine|amod|END_ENTITY	Biomarkers of apoptosis : release of cytochrome_c , activation of caspase-3 , induction of 8-hydroxy-2 ' - deoxyguanosine , increased 3-nitrotyrosine , and alteration of p53 gene .
11997663	0	cytochrome_c	13,25	caspase-3	95,104	cytochrome c	caspase-3	54205	836	Gene	Gene	release|amod|START_ENTITY Induction|nmod|release requires|nsubj|Induction requires|xcomp|END_ENTITY	Induction of cytochrome_c release and apoptosis by Hck-SH3 domain-mediated signalling requires caspase-3 .
26334686	0	cytochrome_c	39,51	caspase-3	63,72	cytochrome c	caspase-3	54205	836	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Purification and characterization of a cytochrome_c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus_arrhizus .
15763985	0	cytochrome_c	142,154	caspase-8	98,107	cytochrome c	caspase-8	54205	841	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Upon drug-induced apoptosis expression of prostate-apoptosis-response-gene-4 promotes cleavage of caspase-8 , bid and mitochondrial release of cytochrome_c .
10393175	0	cytochrome_c	8,20	caspase-9	64,73	cytochrome c	caspase-9	54205	842	Gene	Gene	Role|nmod|START_ENTITY hydrolysis|nsubj|Role hydrolysis|nmod|activation activation|amod|END_ENTITY	Role of cytochrome_c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis .
10673981	0	cytochrome_c	66,78	caspase-9	105,114	cytochrome c	caspase-9	54205	842	Gene	Gene	release|amod|START_ENTITY flavonoids|nmod|release flavonoids|acl|END_ENTITY	Induction of apoptosis by apigenin and related flavonoids through cytochrome_c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells .
11312805	0	cytochrome_c	75,87	caspase-9	114,123	cytochrome c	caspase-9	54205	842	Gene	Gene	release|amod|START_ENTITY Induction|nmod|release Induction|acl|END_ENTITY	Induction of apoptosis by the oolong tea polyphenol_theasinensin_A through cytochrome_c release and activation of caspase-9 and caspase-3 in human U937 cells .
11577712	0	cytochrome_c	114,126	caspase-9	48,57	cytochrome c	caspase-9	54205	842	Gene	Gene	release|nmod|START_ENTITY CAD|nmod|release induction|dep|CAD induction|dep|activation activation|acl|END_ENTITY	Apoptosis induction by T-2_toxin : activation of caspase-9 , caspase-3 , and DFF-40 / CAD through cytosolic release of cytochrome_c in HL-60 cells .
12954616	0	cytochrome_c	86,98	caspase-9	48,57	cytochrome c	caspase-9	54205	842	Gene	Gene	resistance|amod|START_ENTITY model|nmod|resistance cells|dep|model mediated|nmod|cells mediated|xcomp|independent independent|advcl|END_ENTITY	UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells : a model for cytochrome_c resistance .
14972545	0	cytochrome_c	87,99	caspase-9	100,109	cytochrome c	caspase-9	54205	842	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Avian_encephalomyelitis_virus nonstructural protein 2C induces apoptosis by activating cytochrome_c / caspase-9 pathway .
15008459	0	cytochrome_c	103,115	caspase-9	116,125	cytochrome c	caspase-9	54205	842	Gene	Gene	/|amod|START_ENTITY dependent|nmod|/ apoptosome|amod|dependent apoptosome|amod|END_ENTITY	Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation , dependent on the cytochrome_c / caspase-9 apoptosome .
15703181	0	cytochrome_c	72,84	caspase-9	27,36	cytochrome c	caspase-9	54205	842	Gene	Gene	downstream|nmod|START_ENTITY kinase|nmod|downstream kinase|dobj|activation activation|amod|END_ENTITY	Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome_c .
20227384	0	cytochrome_c	40,52	caspase-9	107,116	cytochrome c	caspase-9	54205	842	Gene	Gene	START_ENTITY|acl|play play|nmod|apoptosis apoptosis|acl|signaling signaling|advcl|blocking blocking|dobj|activation activation|amod|END_ENTITY	Nitration of tyrosine 74 prevents human cytochrome_c to play a key role in apoptosis signaling by blocking caspase-9 activation .
10518027	0	cytochrome_c	41,53	caspase_3	87,96	cytochrome c	caspase 3	54205	836	Gene	Gene	START_ENTITY|nmod|mitochondria mitochondria|acl:relcl|precedes precedes|dobj|activation activation|amod|END_ENTITY	NO induces a cGMP-independent release of cytochrome_c from mitochondria which precedes caspase_3 activation in insulin producing RINm5F cells .
12120809	0	cytochrome_c	108,120	caspase_3	139,148	cytochrome c	caspase 3	54205	836	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Induction of apoptosis in a human erythroleukemic cell line K562 by tylophora alkaloids involves release of cytochrome_c and activation of caspase_3 .
15533592	0	cytochrome_c	90,102	caspase_3	112,121	cytochrome c	caspase 3	54205	836	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Beauvericin induces cytotoxic effects in human acute_lymphoblastic_leukemia cells through cytochrome_c release , caspase_3 activation : the causative role of calcium .
17588735	0	cytochrome_c	86,98	caspase_3	129,138	cytochrome c	caspase 3	54205	836	Gene	Gene	B|compound|START_ENTITY transferred|nmod|B transferred|nmod|END_ENTITY	Cell death signal by glycine - and proline-rich plant glycoprotein is transferred from cytochrome_c and nuclear factor kappa B to caspase_3 in Hep3B cells .
25796504	0	cytochrome_c	44,56	cyt_c	58,63	cytochrome c	TRAIL	54205	8743	Gene	Gene	release|amod|START_ENTITY release|dep|END_ENTITY	Cisplatin-mediated c-myc overexpression and cytochrome_c -LRB- cyt_c -RRB- release result in the up-regulation of the death receptors DR4 and DR5 and the activation of caspase_3 and caspase_9 , likely responsible for the TRAIL-sensitizing effect of cisplatin .
10915781	0	cytochrome_c	105,117	cytochrome_c	53,65	cytochrome c	cytochrome c	54205	54205	Gene	Gene	efflux|nmod|START_ENTITY oxidase|dobj|efflux oxidase|nsubj|gastrins gastrins|nmod|cells cells|amod|END_ENTITY	Autocrine gastrins in colon_cancer cells Up-regulate cytochrome_c oxidase Vb and down-regulate efflux of cytochrome_c and activation of caspase-3 .
10915781	0	cytochrome_c	53,65	cytochrome_c	105,117	cytochrome c	cytochrome c	54205	54205	Gene	Gene	cells|amod|START_ENTITY gastrins|nmod|cells oxidase|nsubj|gastrins oxidase|dobj|efflux efflux|nmod|END_ENTITY	Autocrine gastrins in colon_cancer cells Up-regulate cytochrome_c oxidase Vb and down-regulate efflux of cytochrome_c and activation of caspase-3 .
16699948	0	cytochrome_c	48,60	leucine-rich_alpha-2-glycoprotein-1	6,41	cytochrome c	leucine-rich alpha-2-glycoprotein-1	54205	116844	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Serum leucine-rich_alpha-2-glycoprotein-1 binds cytochrome_c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay .
229914	0	cytochrome_c	15,27	phosvitin	53,62	cytochrome c	phosvitin	54205	1460	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cytochrome_c with the phosphorprotein phosvitin .
2992394	0	cytochrome_c	27,39	phosvitin	68,77	cytochrome c	phosvitin	54205	1460	Gene	Gene	Oxidation|nmod|START_ENTITY bound|nsubj|Oxidation bound|nmod|END_ENTITY	Oxidation and reduction of cytochrome_c bound to the phosphoprotein phosvitin .
18685863	0	cytochrome_c-oxidase	12,32	COI	34,37	cytochrome c-oxidase	COI	172832(Tax:6239)	172832(Tax:6239)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of cytochrome_c-oxidase -LRB- COI -RRB- gene of mitochondrial DNA from the Trichinella spp .
10803883	0	cytochrome_c_oxidase_subunit-1	46,76	COX1	78,82	cytochrome c oxidase subunit-1	COX1	854598(Tax:4932)	854598(Tax:4932)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Mss51p , a putative translational activator of cytochrome_c_oxidase_subunit-1 -LRB- COX1 -RRB- mRNA , is required for synthesis of Cox1p in Saccharomyces_cerevisiae .
16147869	0	cytochrome_c_oxidase_subunit_I	44,74	COI	76,79	cytochrome c oxidase subunit I	COI	19893533	19893533	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evolutionary and structural analysis of the cytochrome_c_oxidase_subunit_I -LRB- COI -RRB- gene from Haematobia irritans , Stomoxys calcitrans and Musca domestica -LRB- Diptera : Muscidae -RRB- mitochondrial DNA .
20654571	0	cytochrome_c_oxidase_subunit_I	83,113	COI	115,118	cytochrome c oxidase subunit I	COI	8250942(Tax:334426)	8250942(Tax:334426)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular differentiation of Angiostrongylus taxa -LRB- Nematoda : Angiostrongylidae -RRB- by cytochrome_c_oxidase_subunit_I -LRB- COI -RRB- gene sequences .
7488164	0	cytochrome_c_oxidase_subunit_VI	25,56	COX6	63,67	cytochrome c oxidase subunit VI	COX6	856448(Tax:4932)	856448(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Oxygen regulation of the cytochrome_c_oxidase_subunit_VI gene , COX6 , in Saccharomyces_cerevisiae .
7575509	0	cytochrome_c_oxidase_subunit_VI	79,110	COX6	117,121	cytochrome c oxidase subunit VI	COX6	856448(Tax:4932)	856448(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	pH and the cAMP-dependent protein kinase mediate growth phase induction of the cytochrome_c_oxidase_subunit_VI gene , COX6 , in Saccharomyces_cerevisiae .
22232919	0	cytochrome_oxidase_I	145,165	COI	172,175	cytochrome oxidase I	COI	4512	4512	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Molecular phylogeny and the time of divergence of minges -LRB- Chironomidae , Nematocera , Diptera -RRB- inferred from a partial nucleotide sequence of the cytochrome_oxidase_I gene -LRB- COI -RRB- -RSB- .
20127754	0	cytochrome_oxidase_subunit_II	36,65	COII	67,71	cytochrome oxidase subunit II	COII	10964132	10964132	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of two haplotypes of cytochrome_oxidase_subunit_II -LRB- COII -RRB- gene of the Formosan_subterranean_termite , Coptotermes_formosanus Shiraki -LRB- Isoptera : Rhinotermitidae -RRB- , in southern Mississippi .
10748148	0	cytohesin-1	41,52	ARD1	97,101	cytohesin-1	ARD1	9267	373	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein -LRB- ARD1 -RRB- .
8706128	0	cytohesin-1	59,70	ICAM-1	41,47	cytohesin-1	ICAM-1	9267	3383	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Alpha L beta 2 integrin/LFA -1 binding to ICAM-1 induced by cytohesin-1 , a cytoplasmic regulatory molecule .
22659138	0	cytohesin-2	41,52	Arf6	0,4	cytohesin-2	Arf6	19158(Tax:10090)	11845(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Arf6 guanine-nucleotide exchange factor , cytohesin-2 , interacts with actinin-1 to regulate neurite extension .
25326380	0	cytohesin-2	40,51	Arf6	0,4	cytohesin-2	Arf6	19158(Tax:10090)	11845(Tax:10090)	Gene	Gene	binds|amod|START_ENTITY binds|nsubj|factor factor|nummod|END_ENTITY	Arf6 guanine_nucleotide exchange factor cytohesin-2 binds to CCDC120 and is transported along neurites to mediate neurite growth .
12920129	0	cytohesin_2	68,79	Interaction_protein_for_cytohesin_exchange_factors_1	0,52	cytohesin 2	Interaction protein for cytohesin exchange factors 1	9266	26034	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Interaction_protein_for_cytohesin_exchange_factors_1 -LRB- IPCEF1 -RRB- binds cytohesin_2 and modifies its activity .
19744714	0	cytohesin_binder_and_regulator	16,46	Cybr	8,12	cytohesin binder and regulator	Cybr	227929(Tax:10090)	227929(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of Cybr , a cytohesin_binder_and_regulator , in CD4 -LRB- + -RRB- T-cell function and host immunity .
12498994	0	cytokeratin-19	14,28	cytokeratin-20	31,45	cytokeratin-19	cytokeratin-20	3880	54474	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Evaluation of cytokeratin-19 _ cytokeratin-20 and interleukin-6 in Egyptian bladder_cancer patients .
12498994	0	cytokeratin-20	31,45	cytokeratin-19	14,28	cytokeratin-20	cytokeratin-19	54474	3880	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Evaluation of cytokeratin-19 _ cytokeratin-20 and interleukin-6 in Egyptian bladder_cancer patients .
25725287	0	cytokeratin8	15,27	Sec8	0,4	cytokeratin8	Sec8	3856	60412	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways .
17591979	0	cytokeratin_1	56,69	Myeloperoxidase	0,15	cytokeratin 1	Myeloperoxidase	3848	4353	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Myeloperoxidase interacts with endothelial cell-surface cytokeratin_1 and modulates bradykinin production by the plasma Kallikrein-Kinin system .
1385306	0	cytokeratin_13	29,43	KRT13	50,55	cytokeratin 13	KRT13	3860	3860	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal mapping of human cytokeratin_13 gene -LRB- KRT13 -RRB- .
10692113	0	cytokeratin_16	26,40	beta-endorphin	0,14	cytokeratin 16	beta-endorphin	3868	5443	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	beta-endorphin stimulates cytokeratin_16 expression and downregulates mu-opiate_receptor expression in human epidermis .
12477250	0	cytokeratin_17	19,33	US3	65,68	cytokeratin 17	US3	3872	1487355(Tax:10310)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Phosphorylation of cytokeratin_17 by herpes_simplex_virus_type_2 US3 protein kinase .
21356351	0	cytokeratin_17	243,257	autoimmune_regulator	4,24	cytokeratin 17	autoimmune regulator	3872	326	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	The autoimmune_regulator -LRB- AIRE -RRB- , which is defective in autoimmune_polyendocrinopathy-candidiasis-ectodermal_dystrophy patients , is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin_17 .
15987600	0	cytokeratin_18	143,157	Epithelium-specific_ets_transcription_factor_2	0,46	cytokeratin 18	Epithelium-specific ets transcription factor 2	3875	2001	Gene	Gene	intron|compound|START_ENTITY interaction|nmod|intron upregulates|nmod|interaction upregulates|nsubj|END_ENTITY	Epithelium-specific_ets_transcription_factor_2 upregulates cytokeratin_18 expression in pulmonary epithelial cells through an interaction with cytokeratin_18 intron 1 .
15987600	0	cytokeratin_18	59,73	Epithelium-specific_ets_transcription_factor_2	0,46	cytokeratin 18	Epithelium-specific ets transcription factor 2	3875	2001	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Epithelium-specific_ets_transcription_factor_2 upregulates cytokeratin_18 expression in pulmonary epithelial cells through an interaction with cytokeratin_18 intron 1 .
18853744	0	cytokeratin_18	42,56	plectin	15,22	cytokeratin 18	plectin	3875	5339	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of plectin with modulation of cytokeratin_18 in human liver cells during staurosporine-induced apoptosis .
20856226	0	cytokeratin_19	32,46	Epidermal_growth_factor	0,23	cytokeratin 19	Epidermal growth factor	3880	1950	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces cytokeratin_19 expression accompanied by increased_growth_abilities in human hepatocellular_carcinoma .
16245643	0	cytokeratin_19	36,50	PCNA	103,107	cytokeratin 19	PCNA	3880	5111	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of cytokeratin_19 , involucrin and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in cultured human gingival epithelial sheets .
16459887	0	cytokeratin_19	36,50	PCNA	103,107	cytokeratin 19	PCNA	3880	5111	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of cytokeratin_19 , involucrin and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in cultured human gingival epithelial sheets .
7515894	0	cytokeratin_19	126,140	p53	113,116	cytokeratin 19	p53	3880	7157	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Analysis of HPV16 E6 and mutant p53-transfected keratinocytes in reconstituted epidermis suggests that wild-type p53 inhibits cytokeratin_19 expression .
22348416	0	cytokeratin_20	8,22	MUC5AC	0,6	cytokeratin 20	MUC5AC	54474	4586	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	MUC5AC , cytokeratin_20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital_pulmonary_airway_malformations .
21677534	0	cytokeratin_20	26,40	SATB2	0,5	cytokeratin 20	SATB2	54474	23314	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	SATB2 in combination with cytokeratin_20 identifies over 95 % of all colorectal_carcinomas .
16280744	0	cytokeratin_20	116,130	Uroplakin_II	0,12	cytokeratin 20	Uroplakin II	54474	7379	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Uroplakin_II as a promising marker for molecular diagnosis of nodal metastases from bladder_cancer : comparison with cytokeratin_20 .
24901475	0	cytokeratin_20	8,22	thyroid_transcription_factor-1	42,72	cytokeratin 20	thyroid transcription factor-1	54474	7080	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Loss of cytokeratin_20 and acquisition of thyroid_transcription_factor-1 expression in a merkel cell carcinoma metastasis to the brain .
7510223	0	cytokeratin_3	24,37	KRT3	44,48	cytokeratin 3	KRT3	3850	3850	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human cytokeratin_3 gene -LRB- KRT3 -RRB- to 12q12 -- > q13 by FISH .
19419944	0	cytokeratin_7	22,35	cytokeratin_8	37,50	cytokeratin 7	cytokeratin 8	3855	3856	Gene	Gene	phosphatase|appos|START_ENTITY END_ENTITY|nsubj|phosphatase	Alkaline phosphatase , cytokeratin_7 , cytokeratin_8 in the diagnosis of primary lung_adenocarcinoma from 148 pleura fluids specimens .
26769854	0	cytokeratin_8	54,67	LILRB3	31,37	cytokeratin 8	LILRB3	3856	11025	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin_8 - associated ligand on necrotic glandular epithelial cells .
19419944	0	cytokeratin_8	37,50	cytokeratin_7	22,35	cytokeratin 8	cytokeratin 7	3856	3855	Gene	Gene	START_ENTITY|nsubj|phosphatase phosphatase|appos|END_ENTITY	Alkaline phosphatase , cytokeratin_7 , cytokeratin_8 in the diagnosis of primary lung_adenocarcinoma from 148 pleura fluids specimens .
11514587	0	cytokine-independent_survival_kinase	14,50	CISK	52,56	cytokine-independent survival kinase	CISK	23678	23678	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of cytokine-independent_survival_kinase -LRB- CISK -RRB- by the Phox homology domain and phosphoinositides .
14604990	0	cytokine-independent_survival_kinase	93,129	PDK-1	143,148	cytokine-independent survival kinase	PDK-1	23678	5163	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Peroxisomal targeting as a tool for assaying potein-protein interactions in the living cell : cytokine-independent_survival_kinase -LRB- CISK -RRB- binds PDK-1 in vivo in a phosphorylation-dependent manner .
9576061	0	cytokine-induced_neutrophil_chemoattractant-2	56,101	CINC-2	103,109	cytokine-induced neutrophil chemoattractant-2	CINC-2	171551(Tax:10116)	171551(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gene structure , cDNA cloning , and expression of the rat cytokine-induced_neutrophil_chemoattractant-2 -LRB- CINC-2 -RRB- gene .
19641190	0	cytokine_receptor	26,43	CRLF2	50,55	cytokine receptor	CRLF2	8809	64109	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|appos|END_ENTITY	Deregulated expression of cytokine_receptor gene , CRLF2 , is involved in lymphoid transformation in B-cell precursor acute_lymphoblastic_leukemia .
12670405	0	cytokine_receptor	14,31	SOCS1	45,50	cytokine receptor	SOCS1	8809	8651	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of cytokine_receptor signaling by SOCS1 .
19098008	0	cytokine_receptor	99,116	p53	22,25	cytokine receptor	p53	8809	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine_receptor signaling .
17684298	0	cytoplasmic_adaptor	15,34	Act1	43,47	cytoplasmic adaptor	Act1	353376	10758	Gene	Gene	protein|compound|START_ENTITY role|nmod|protein END_ENTITY|nsubj|role	A role for the cytoplasmic_adaptor protein Act1 in mediating IL-17 signaling .
2237442	0	cytoplasmic_protein	2,21	H-Ras	54,59	cytoplasmic protein	H-Ras	8548	3265	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|nmod|END_ENTITY	A cytoplasmic_protein inhibits the GTPase activity of H-Ras in a phospholipid-dependent manner .
3558401	1	cytoplasmic_retinol-binding_protein	172,207	retinol-binding_protein	145,168	cytoplasmic retinol-binding protein	retinol-binding protein	537379(Tax:9913)	281444(Tax:9913)	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Retinol transfer from plasma retinol-binding_protein to cytoplasmic_retinol-binding_protein with retinyl-ester formation as the intermediate step .
8273584	0	cytosolic_PLA2	27,41	Interleukin-1_beta	0,18	cytosolic PLA2	Interleukin-1 beta	5321	3553	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1_beta induces cytosolic_PLA2 in parallel with prostaglandin_E2 in rheumatoid synovial fibroblasts .
2364283	0	cytosolic_aspartate_aminotransferase	22,58	cAAT	60,64	cytosolic aspartate aminotransferase	cAAT	24401(Tax:10116)	24401(Tax:10116)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of cytosolic_aspartate_aminotransferase -LRB- cAAT -RRB- in axon terminals that form synapses in the rat cerebellar cortex .
15789223	0	cytosolic_glutathione_peroxidase	22,54	cGPx	56,60	cytosolic glutathione peroxidase	cGPx	14775(Tax:10090)	14775(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression pattern of cytosolic_glutathione_peroxidase -LRB- cGPx -RRB- mRNA during mouse embryogenesis .
15375180	0	cytosolic_lipid-protein_particle	73,105	Apolipoprotein_A-I	0,18	cytosolic lipid-protein particle	Apolipoprotein A-I	301117(Tax:10116)	25081(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Apolipoprotein_A-I induces translocation of protein_kinase_C -LSB- alpha -RSB- to a cytosolic_lipid-protein_particle in astrocytes .
20635443	0	cytosolic_phospholipase_A2	11,37	15-prostaglandin_dehydrogenase	39,69	cytosolic phospholipase A2	15-prostaglandin dehydrogenase	5321	3248	Gene	Gene	expressions|amod|START_ENTITY expressions|amod|END_ENTITY	Impacts of cytosolic_phospholipase_A2 , 15-prostaglandin_dehydrogenase , and cyclooxygenase-2 expressions on tumor progression in colorectal_cancer .
8665944	0	cytosolic_phospholipase_A2	18,44	5-lipoxygenase	46,60	cytosolic phospholipase A2	5-lipoxygenase	5321	240	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Colocalization of cytosolic_phospholipase_A2 , 5-lipoxygenase , and 5-lipoxygenase-activating protein at the nuclear membrane of A23187-stimulated human neutrophils .
8135848	0	cytosolic_phospholipase_A2	24,50	Endothelin-1	0,12	cytosolic phospholipase A2	Endothelin-1	100750927	100768493	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates cytosolic_phospholipase_A2 in Chinese_hamster ovary cells stably expressing the human ETA_or_ETB_receptor subtype .
7649158	0	cytosolic_phospholipase_A2	125,151	Epidermal_growth_factor	0,23	cytosolic phospholipase A2	Epidermal growth factor	5321	1950	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic_phospholipase_A2 .
22231145	0	cytosolic_phospholipase_A2	51,77	Heme_oxygenase_1	0,16	cytosolic phospholipase A2	Heme oxygenase 1	18783(Tax:10090)	15368(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Heme_oxygenase_1 attenuates interleukin-1b-induced cytosolic_phospholipase_A2 expression via a decrease in NADPH oxidase/reactive oxygen species/activator _ protein_1 activation in rheumatoid_arthritis synovial fibroblasts .
1429687	0	cytosolic_phospholipase_A2	48,74	Interleukin-1_alpha	0,19	cytosolic phospholipase A2	Interleukin-1 alpha	5321	3552	Gene	Gene	accumulation|nmod|START_ENTITY induces|dobj|accumulation induces|nsubj|END_ENTITY	Interleukin-1_alpha induces the accumulation of cytosolic_phospholipase_A2 and the release of prostaglandin_E2 in human fibroblasts .
7480804	0	cytosolic_phospholipase_A2	57,83	Interleukin-1_beta	0,18	cytosolic phospholipase A2	Interleukin-1 beta	5321	3553	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Interleukin-1_beta induces the synthesis and activity of cytosolic_phospholipase_A2 and the release of prostaglandin_E2 in human amnion-derived WISH cells .
9042332	0	cytosolic_phospholipase_A2	46,72	Leukemia_inhibitory_factor	0,26	cytosolic phospholipase A2	Leukemia inhibitory factor	5321	3976	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Leukemia_inhibitory_factor induces the 85-kDa cytosolic_phospholipase_A2 gene expression in cultured human bronchial epithelial cells .
24069158	0	cytosolic_phospholipase_A2	14,40	TNF-a	0,5	cytosolic phospholipase A2	TNF-a	5321	7124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNF-a induces cytosolic_phospholipase_A2 expression in human lung epithelial cells via JNK1/2 - _ and_p38 MAPK-dependent AP-1 activation .
8611631	0	cytosolic_phospholipase_A2	47,73	Tumor_necrosis_factor-alpha	0,27	cytosolic phospholipase A2	Tumor necrosis factor-alpha	5321	7124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces the 85-kDa cytosolic_phospholipase_A2 gene expression in human bronchial epithelial cells .
9450544	0	cytosolic_phospholipase_A2	88,114	Vascular_endothelial_growth_factor	0,34	cytosolic phospholipase A2	Vascular endothelial growth factor	5321	7422	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor stimulates prostacyclin production and activation of cytosolic_phospholipase_A2 in endothelial cells via p42/p44 mitogen-activated protein kinase .
10501211	0	cytosolic_phospholipase_A2	157,183	cyclooxygenase-2	207,223	cytosolic phospholipase A2	cyclooxygenase-2	5321	5743	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Signaling mechanisms involved in the activation of arachidonic_acid metabolism in human astrocytoma cells by tumor_necrosis_factor-alpha : phosphorylation of cytosolic_phospholipase_A2 and transactivation of cyclooxygenase-2 .
17161492	0	cytosolic_phospholipase_A2	51,77	endothelin-1	16,28	cytosolic phospholipase A2	endothelin-1	24653(Tax:10116)	24323(Tax:10116)	Gene	Gene	production|amod|START_ENTITY activation|nmod|production activation|amod|END_ENTITY	LPS exacerbates endothelin-1 induced activation of cytosolic_phospholipase_A2 and thromboxane_A2 production from Kupffer cells of the prefibrotic rat liver .
9593858	0	cytosolic_phospholipase_A2	62,88	endothelin-1	34,46	cytosolic phospholipase A2	endothelin-1	5321	1906	Gene	Gene	release|amod|START_ENTITY stimulation|nmod|release stimulation|amod|END_ENTITY	Role of protein_kinase_C_alpha in endothelin-1 stimulation of cytosolic_phospholipase_A2 and arachidonic_acid release in cultured cat iris sphincter smooth muscle cells .
8970973	0	cytosolic_phospholipase_A2	16,42	tumor_necrosis_factor	101,122	cytosolic phospholipase A2	tumor necrosis factor	5321	7124	Gene	Gene	activity|nmod|START_ENTITY required|nsubjpass|activity required|nmod|END_ENTITY	The activity of cytosolic_phospholipase_A2 is required for the lysis of adenovirus-infected cells by tumor_necrosis_factor .
16869890	0	cytosolic_sialidase	49,68	Neu2	69,73	cytosolic sialidase	Neu2	23956(Tax:10090)	23956(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor_1 signaling regulates cytosolic_sialidase Neu2 expression during myoblast differentiation and hypertrophy .
9170110	0	cytostatic_factor	71,88	transglutaminase	22,38	cytostatic factor	transglutaminase	1437	7051	Gene	Gene	development|nmod|START_ENTITY END_ENTITY|nmod|development	Role of amphibian egg transglutaminase in the development of secondary cytostatic_factor in vitro .
1372434	0	cytotactin	18,28	Evx-1	70,75	cytotactin	Evx-1	21923(Tax:10090)	14028(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY Activation|nmod|promoter Activation|nmod|END_ENTITY	Activation of the cytotactin promoter by the homeobox-containing gene Evx-1 .
1704192	0	cytotactin	68,78	neural_cell_adhesion_molecules	23,53	cytotactin	neural cell adhesion molecules	3371	4684	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of neural_cell_adhesion_molecules and tenascin -LRB- cytotactin -RRB- during wound healing .
2436234	0	cytotactin	83,93	proteoglycan	2,14	cytotactin	proteoglycan	396440(Tax:9031)	395565(Tax:9031)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	A proteoglycan with HNK-1 antigenic determinants is a neuron-associated ligand for cytotactin .
12534352	0	cytotoxic_T-lymphocyte-associated_antigen-4	15,58	CTLA-4	60,66	cytotoxic T-lymphocyte-associated antigen-4	CTLA-4	1493	1493	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of cytotoxic_T-lymphocyte-associated_antigen-4 -LRB- CTLA-4 -RRB- gene polymorphism and non-genetic factors with Graves ' _ ophthalmopathy in European and Japanese populations .
24269199	0	cytotoxic_T-lymphocyte-associated_protein_4	10,53	CD4	57,60	cytotoxic T-lymphocyte-associated protein 4	CD4	12477(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Effect of cytotoxic_T-lymphocyte-associated_protein_4 on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- regulatory T cells in murine schistosomiasis japonica .
24385694	0	cytotoxic_T-lymphocyte_antigen-4	10,42	TNF-alpha	44,53	cytotoxic T-lymphocyte antigen-4	TNF-alpha	1493	7124	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Effect of cytotoxic_T-lymphocyte_antigen-4 , TNF-alpha polymorphisms on osteosarcoma : evidences from a meta-analysis .
24028204	0	cytotoxic_T-lymphocyte_antigen_4	14,46	CD4	50,53	cytotoxic T-lymphocyte antigen 4	CD4	1493	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Expression of cytotoxic_T-lymphocyte_antigen_4 on CD4 + and CD8 + T cells is increased in acute_lung_injury .
11976786	0	cytotoxic_T-lymphocyte_antigen_4	28,60	CTLA4	63,68	cytotoxic T-lymphocyte antigen 4	CTLA4	1493	1493	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism in the human cytotoxic_T-lymphocyte_antigen_4 -LRB- CTLA4 -RRB- gene -LRB- exon 1 +49 -RRB- alters T-cell activation .
23138463	0	cytotoxic_T_lymphocyte-associated_antigen-4	44,87	ICOS	126,130	cytotoxic T lymphocyte-associated antigen-4	ICOS	1493	29851	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association of Hashimoto 's _ thyroiditis with cytotoxic_T_lymphocyte-associated_antigen-4 -LRB- CTLA-4 -RRB- and inducible_co-stimulator -LRB- ICOS -RRB- genes in a Kuwaiti population .
10197076	0	cytotoxic_T_lymphocyte_antigen-4	2,34	CTLA-4	36,42	cytotoxic T lymphocyte antigen-4	CTLA-4	1493	1493	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	A cytotoxic_T_lymphocyte_antigen-4 -LRB- CTLA-4 -RRB- gene polymorphism is associated with autoimmune_Addison 's _ disease in English patients .
23039885	0	cytotoxic_T_lymphocyte_antigen_4	41,73	CD25	95,99	cytotoxic T lymphocyte antigen 4	CD25	1493	3559	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	FOXP3 , CBLB and ITCH gene expression and cytotoxic_T_lymphocyte_antigen_4 expression on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- T cells in multiple_sclerosis .
23039885	0	cytotoxic_T_lymphocyte_antigen_4	41,73	CD4	88,91	cytotoxic T lymphocyte antigen 4	CD4	1493	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|CD25 CD25|compound|END_ENTITY	FOXP3 , CBLB and ITCH gene expression and cytotoxic_T_lymphocyte_antigen_4 expression on CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- T cells in multiple_sclerosis .
19147248	0	cytotoxic_T_lymphocyte_antigen_4	51,83	CTLA-4	85,91	cytotoxic T lymphocyte antigen 4	CTLA-4	1493	1493	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interactions between programmed_death_1 -LRB- PD-1 -RRB- and cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA-4 -RRB- gene polymorphisms in type 1 diabetes .
21286781	0	cytotoxic_ribonuclease	2,24	P-glycoprotein	57,71	cytotoxic ribonuclease	P-glycoprotein	6037	5243	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|level level|nmod|END_ENTITY	A cytotoxic_ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines .
21124961	0	d-Asb11	23,30	cul5	31,35	d-Asb11	cul5	791758(Tax:7955)	327215(Tax:7955)	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo .
12823441	0	d-dopachrome_tautomerase	41,65	macrophage_migration_inhibitory_factor	114,152	d-dopachrome tautomerase	macrophage migration inhibitory factor	1652	4282	Gene	Gene	activity|amod|START_ENTITY activity|acl:relcl|correlates correlates|nmod|END_ENTITY	UVB-induced inflammation gives increased d-dopachrome_tautomerase activity in blister fluid which correlates with macrophage_migration_inhibitory_factor .
19594484	0	d4eBP	0,5	dTOR	30,34	d4eBP	dTOR	33569(Tax:7227)	47396(Tax:7227)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila .
2552440	0	dATPase	82,89	ATPase	74,80	dATPase	ATPase	36731(Tax:7227)	36731(Tax:7227)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	An RNA polymerase II transcription factor has an associated DNA-dependent ATPase -LRB- dATPase -RRB- activity strongly stimulated by the TATA region of promoters .
18367646	0	dCAP-D3	99,106	RBF1	0,4	dCAP-D3	RBF1	33778(Tax:7227)	31027(Tax:7227)	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|nsubj|END_ENTITY	RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3 .
12142097	0	dCK	30,33	deoxycytidine_kinase	8,28	dCK	deoxycytidine kinase	39429(Tax:7227)	13178(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Role of deoxycytidine_kinase -LRB- dCK -RRB- activity in gemcitabine 's radioenhancement in mice and human cell lines in vitro .
15520873	0	dCK	43,46	deoxycytidine_kinase	21,41	dCK	deoxycytidine kinase	43828(Tax:7227)	1633	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	-LSB- Special function of deoxycytidine_kinase -LRB- dCK -RRB- in the activation of chemotherapeutic nucleoside analogs and in the inhibition of cell proliferation -RSB- .
7874009	0	dCK	44,47	deoxycytidine_kinase	22,42	dCK	deoxycytidine kinase	39429(Tax:7227)	1633	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Low expression of the deoxycytidine_kinase -LRB- dCK -RRB- gene in a 1-beta-D-arabinofuranosylcytosine-resistant human leukemic cell line KY-Ra .
9869205	0	dCK	102,105	deoxycytidine_kinase	14,34	dCK	deoxycytidine kinase	39429(Tax:7227)	1633	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene Expression|dep|expression Expression|nmod|gene gene|amod|END_ENTITY	Expression of deoxycytidine_kinase -LRB- dCK -RRB- gene in leukemic cells in childhood : decreased expression of dCK gene in relapsed leukemia .
9869205	0	dCK	36,39	deoxycytidine_kinase	14,34	dCK	deoxycytidine kinase	39429(Tax:7227)	1633	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of deoxycytidine_kinase -LRB- dCK -RRB- gene in leukemic cells in childhood : decreased expression of dCK gene in relapsed leukemia .
20980603	0	dCLOCK	46,52	PERIOD	22,28	dCLOCK	PERIOD	38872(Tax:7227)	31251(Tax:7227)	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|compound|END_ENTITY	Two distinct modes of PERIOD recruitment onto dCLOCK reveal a novel role for TIMELESS in circadian transcription .
22024240	0	dCMP	4,8	Rev1	39,43	dCMP	Rev1	248126	854527(Tax:4932)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites .
11328604	0	dDAF	12,16	CD55	18,22	dDAF	CD55	34826(Tax:7227)	13136(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A synthetic dDAF _ -LRB- CD55 -RRB- gene based on optimal codon usage for transgenic animals .
12077345	0	dDREF	37,42	Mi-2	11,15	dDREF	Mi-2	34328(Tax:7227)	40170(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA-binding activity .
16949685	0	dDREF	44,49	distal-less	11,22	dDREF	distal-less	34328(Tax:7227)	37973(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila distal-less negatively regulates dDREF by inhibiting its DNA binding activity .
16671894	0	dDYRK2	0,6	SNR1	69,73	dDYRK2	SNR1	34831(Tax:7227)	40657(Tax:7227)	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX .
20808898	0	dE2F1	39,44	Tuberous_sclerosis_complex_1	0,28	dE2F1	Tuberous sclerosis complex 1	42550(Tax:7227)	42862(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tuberous_sclerosis_complex_1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival .
11979508	0	dELL	0,4	ELL	64,67	dELL	ELL	40171(Tax:7227)	40171(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	dELL , a drosophila homologue of transcription elongation factor ELL -LRB- Eleven-nineteen Lysine rich_Leukemia -RRB- , is required for early development .
15680371	0	dGATAe	39,45	GATA	21,25	dGATAe	GATA	41945(Tax:7227)	42283(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	An endoderm-specific GATA factor gene , dGATAe , is required for the terminal differentiation of the Drosophila endoderm .
8524786	0	dGq_alpha-3	56,67	G_protein_alpha_subunit	31,54	dGq alpha-3	G protein alpha subunit	36384(Tax:7227)	36384(Tax:7227)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of a Drosophila G_protein_alpha_subunit -LRB- dGq_alpha-3 -RRB- expressed in chemosensory cells and central neurons .
22174740	0	dHCF	24,28	PcG	49,52	dHCF	PcG	43788(Tax:7227)	40358(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Drosophila_melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators .
9724756	0	dLMO	30,34	LIM-only	15,23	dLMO	LIM-only	32846(Tax:7227)	32846(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Drosophila LIM-only gene , dLMO , is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development .
10229200	0	dMax	45,49	Max	68,71	dMax	Max	40095(Tax:7227)	17187(Tax:10090)	Gene	Gene	variant|compound|START_ENTITY variant|nmod|END_ENTITY	Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc .
23336071	0	dMyc	27,31	miR-308	9,16	dMyc	miR-308	31310(Tax:7227)	12798452	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila .
19270172	0	dNAB	17,21	Brinker	37,44	dNAB	Brinker	3346237(Tax:7227)	31665(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The co-regulator dNAB interacts with Brinker to eliminate cells with reduced Dpp signaling .
11526108	0	dNOS	43,47	nitric-oxide_synthase	15,36	dNOS	nitric-oxide synthase	34495(Tax:7227)	34495(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The Drosophila nitric-oxide_synthase gene -LRB- dNOS -RRB- encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators .
10400941	0	dNSF1	28,33	NSF	15,18	dNSF1	NSF	47091(Tax:7227)	47091(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The Drosophila NSF protein , dNSF1 , plays a similar role at neuromuscular and some central synapses .
20579883	0	dPRR	32,36	prorenin_receptor	68,85	dPRR	prorenin receptor	41104(Tax:7227)	10159	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Wnt/Frizzled signaling requires dPRR , the Drosophila homolog of the prorenin_receptor .
20888931	0	dPlod	66,71	lysyl_hydroxylase	47,64	dPlod	lysyl hydroxylase	39265(Tax:7227)	39265(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|Characterisation Characterisation|nmod|END_ENTITY	Characterisation of the Drosophila procollagen lysyl_hydroxylase , dPlod .
10767550	0	dRFX	32,36	RFX	67,70	dRFX	RFX	41266(Tax:7227)	41266(Tax:7227)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Cloning and characterization of dRFX , the Drosophila member of the RFX family of transcription factors .
12039038	0	dSAP18	52,58	Enhancer_of_zeste	11,28	dSAP18	Enhancer of zeste	41965(Tax:7227)	39203(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	Drosophila Enhancer_of_zeste protein interacts with dSAP18 .
23552694	0	dSkp2	29,34	Dacapo	77,83	dSkp2	Dacapo	40548(Tax:7227)	36001(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation .
19594484	0	dTOR	30,34	d4eBP	0,5	dTOR	d4eBP	47396(Tax:7227)	33569(Tax:7227)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila .
19124728	0	dUTPase	16,23	NF-kappa_B	34,44	dUTPase	NF-kappa B	34529(Tax:7227)	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The EBV-encoded dUTPase activates NF-kappa_B through the TLR2 and MyD88-dependent signaling pathway .
19124728	0	dUTPase	16,23	TLR2	57,61	dUTPase	TLR2	34529(Tax:7227)	7097	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	The EBV-encoded dUTPase activates NF-kappa_B through the TLR2 and MyD88-dependent signaling pathway .
15246266	0	dUTPase	77,84	UL72	47,51	dUTPase	UL72	34529(Tax:7227)	3077454(Tax:10359)	Gene	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	Evidence that the human_cytomegalovirus 46-kDa UL72 protein is not an active dUTPase but a late protein dispensable for replication in fibroblasts .
24173231	0	dUTPase	63,70	Us3	38,41	dUTPase	Us3	34529(Tax:7227)	2703401(Tax:10298)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Herpes_simplex_virus_1 protein kinase Us3 phosphorylates viral dUTPase and regulates its catalytic activity in infected cells .
25320299	0	dUTPase	130,137	dUTPase	42,49	dUTPase	dUTPase	34529(Tax:7227)	34529(Tax:7227)	Gene	Gene	Activity|compound|START_ENTITY END_ENTITY|nmod|Activity	Phosphorylation of Herpes_Simplex_Virus_1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System .
25320299	0	dUTPase	42,49	dUTPase	130,137	dUTPase	dUTPase	34529(Tax:7227)	34529(Tax:7227)	Gene	Gene	START_ENTITY|nmod|Activity Activity|compound|END_ENTITY	Phosphorylation of Herpes_Simplex_Virus_1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System .
10567908	0	dUTPase	43,50	deoxyuridine_triphosphatase	14,41	dUTPase	deoxyuridine triphosphatase	34529(Tax:7227)	1854	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of deoxyuridine_triphosphatase -LRB- dUTPase -RRB- in colorectal_tumours .
19052026	0	dUTPase	50,57	deoxyuridine_triphosphatase	21,48	dUTPase	deoxyuridine triphosphatase	34529(Tax:7227)	1854	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Higher expression of deoxyuridine_triphosphatase -LRB- dUTPase -RRB- may predict the metastasis potential of colorectal_cancer .
8139016	0	dUTPase	120,127	p30	88,91	dUTPase	p30	34529(Tax:7227)	201161	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Expression and purification of the mouse_mammary_tumor_virus gag-pro transframe protein p30 and characterization of its dUTPase activity .
10209098	0	daf-18	67,73	PTEN	112,116	daf-18	PTEN	176869(Tax:6239)	5728	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Regulation of dauer larva development in Caenorhabditis_elegans by daf-18 , a homologue of the tumour suppressor PTEN .
15525349	0	damage-induced_neuronal_endopeptidase	14,51	DINE	53,57	damage-induced neuronal endopeptidase	DINE	60417(Tax:10116)	60417(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of damage-induced_neuronal_endopeptidase -LRB- DINE -RRB- mRNA in peri-infarct_cortical_and_thalamic_neurons following middle_cerebral_artery_occlusion .
26879405	0	damaged-DNA_binding_2	6,27	DDB2	0,4	damaged-DNA binding 2	DDB2	1643	1643	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	DDB2 -LRB- damaged-DNA_binding_2 -RRB- protein : a new modulator of nanomechanical properties and cell adhesion of breast_cancer cells .
12181326	0	damaged_DNA_binding_1	101,122	DDB1	124,128	damaged DNA binding 1	DDB1	1642	1642	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a Schizosaccharomyces_pombe_strain deleted for a sequence homologue of the human damaged_DNA_binding_1 -LRB- DDB1 -RRB- gene .
15608685	0	dapk1	0,5	p53	105,108	dapk1	p53	1612	7157	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	dapk1 , encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint , is a transcription target of p53 .
18496192	0	dardarin	110,118	LRRK2	104,109	dardarin	LRRK2	120892	120892	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Outcome of bilateral deep brain subthalamic stimulation in patients carrying the R1441G mutation in the LRRK2 dardarin gene .
23211396	0	darexaban	42,51	factor_Xa	68,77	factor Xa	factor Xa	2159	2159	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	Effect of food on the pharmacokinetics of darexaban , an oral direct factor_Xa inhibitor , in healthy Japanese subjects .
1565462	0	dbl	76,79	vav	32,35	dbl	vav	4168	7409	Gene	Gene	factor|compound|START_ENTITY expressed|nmod|factor expressed|dobj|shares shares|amod|END_ENTITY	The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor , the bcr gene and a yeast gene -LRB- CDC24 -RRB- involved in cytoskeletal organization .
24690231	0	dbl-1	17,22	CEH-28	0,6	dbl-1	CEH-28	179068(Tax:6239)	191619(Tax:6239)	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	CEH-28 activates dbl-1 expression and TGF-b signaling in the C. _ elegans M4 neuron .
10100871	0	dbpA	20,24	Cdk5	31,35	dbpA	Cdk5	8531	1020	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	DNA_binding_protein dbpA binds Cdk5 and inhibits its activity .
19749785	0	dbpA	45,49	DNA_binding_protein_A	22,43	dbpA	DNA binding protein A	8531	8531	Gene	Gene	Upregulation|appos|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of human DNA_binding_protein_A -LRB- dbpA -RRB- in gastric_cancer cells .
7651426	0	dbpA	75,79	mYB-1	90,95	dbpA	mYB-1	8531	22608(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Repression of major histocompatibility complex I-A_beta gene expression by dbpA and dbpB -LRB- mYB-1 -RRB- proteins .
11390977	0	dbpB	50,54	Thrombin	0,8	dbpB	Thrombin	4904	2147	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Thrombin induces the release of the Y-box protein dbpB from mRNA : a mechanism of transcriptional activation .
7541096	0	dck	55,58	deoxycytidine_kinase	33,53	dck	deoxycytidine kinase	79127(Tax:10116)	79127(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	De novo induced mutations in the deoxycytidine_kinase -LRB- dck -RRB- gene in rat leukemic clonal cell lines confer resistance to cytarabine -LRB- AraC -RRB- and 5-aza-2 ' - deoxycytidine -LRB- DAC -RRB- .
7543292	0	dck	206,209	deoxycytidine_kinase	184,204	dck	deoxycytidine kinase	79127(Tax:10116)	79127(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	In vitro-induced resistance to the deoxycytidine analogues cytarabine -LRB- AraC -RRB- and 5-aza-2 ' - deoxycytidine -LRB- DAC -RRB- in a rat model for acute_myeloid_leukemia is mediated by mutations in the deoxycytidine_kinase -LRB- dck -RRB- gene .
12805099	0	deafness-dystonia_peptide	74,99	DDP1	101,105	deafness-dystonia peptide	DDP1	1678	1678	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical and molecular findings in a patient with a novel mutation in the deafness-dystonia_peptide -LRB- DDP1 -RRB- gene .
11489896	0	deafness_dystonia_peptide_1	12,39	DDP1	41,45	deafness dystonia peptide 1	DDP1	1678	1678	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the deafness_dystonia_peptide_1 -LRB- DDP1 -RRB- in import of human Tim23 into the inner membrane of mitochondria .
15302871	0	death-associated_protein_3	19,45	DAP3	47,51	death-associated protein 3	DAP3	7818	7818	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Functional role of death-associated_protein_3 -LRB- DAP3 -RRB- in anoikis .
17056602	0	death-associated_protein_kinase	11,42	DAPK	44,48	death-associated protein kinase	DAPK	1612	1612	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Control of death-associated_protein_kinase -LRB- DAPK -RRB- activity by phosphorylation and proteasomal degradation .
23806751	0	death-associated_protein_kinase	12,43	DAPK	45,49	death-associated protein kinase	DAPK	1612	1612	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of death-associated_protein_kinase -LRB- DAPK -RRB- in endothelial apoptosis under fluid shear stress .
21041719	0	death-associated_protein_kinase	17,48	IL-1b	70,75	death-associated protein kinase	IL-1b	1612	3553	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|production production|compound|END_ENTITY	Tumor suppressor death-associated_protein_kinase is required for full IL-1b production .
18974095	0	death-associated_protein_kinase	51,82	TSC2	41,45	death-associated protein kinase	TSC2	1612	7249	Gene	Gene	death|amod|START_ENTITY END_ENTITY|nmod|death	Peptide combinatorial libraries identify TSC2 as a death-associated_protein_kinase -LRB- DAPK -RRB- death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling .
16520653	0	death-associated_protein_kinase	50,81	nasopharyngeal_carcinoma	90,114	death-associated protein kinase	nasopharyngeal carcinoma	1612	4864	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Effect of methylation-associated silencing of the death-associated_protein_kinase gene on nasopharyngeal_carcinoma .
15910542	0	death_associated_protein_kinase-3	69,102	TCP10L	0,6	death associated protein kinase-3	TCP10L	1613	140290	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	TCP10L is expressed specifically in spermatogenic cells and binds to death_associated_protein_kinase-3 .
26662956	0	death_receptor-5	112,128	caspase-8	138,147	death receptor-5	caspase-8	8795	841	Gene	Gene	caspase-3|amod|START_ENTITY caspase-3|amod|END_ENTITY	Synergistic effect of fisetin combined with sorafenib in human cervical_cancer HeLa cells through activation of death_receptor-5 mediated caspase-8 / caspase-3 and the mitochondria-dependent apoptotic pathway .
24829148	0	death_receptor-6	13,29	S5a	0,3	death receptor-6	S5a	27242	5710	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	S5a binds to death_receptor-6 to induce THP-1 monocytes to differentiate through the activation of the NF-kB pathway .
22593543	0	death_receptor_3	4,20	TL1A	21,25	death receptor 3	TL1A	85030(Tax:10090)	326623(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|essential essential|nsubj|END_ENTITY	The death_receptor_3 / TL1A pathway is essential for efficient development of antiviral CD4 and CD8 T-cell immunity .
16324699	0	death_receptor_3	63,79	interleukin-8	27,40	death receptor 3	interleukin-8	8718	3576	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|gene gene|amod|END_ENTITY	Differential regulation of interleukin-8 gene transcription by death_receptor_3 -LRB- DR3 -RRB- and type I TNF receptor -LRB- TNFRI -RRB- .
21700414	0	death_receptor_4	15,31	Caspase_3_and_5	33,48	death receptor 4	Caspase 3 and 5	8797	836;838	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Association of death_receptor_4 , Caspase_3_and_5 gene polymorphism with increased risk to bladder_cancer in North Indians .
19148581	0	death_receptor_4	16,32	DR4	34,37	death receptor 4	DR4	8797	8797	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Reactivation of death_receptor_4 -LRB- DR4 -RRB- expression sensitizes medulloblastoma cell lines to TRAIL .
19350268	0	death_receptor_4	8,24	DR4	26,29	death receptor 4	DR4	8797	8797	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lack of death_receptor_4 -LRB- DR4 -RRB- expression through gene promoter methylation in gastric_carcinoma .
17914579	0	death_receptor_4	33,49	TRAIL	116,121	death receptor 4	TRAIL	8797	8743	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Glycosylation modulates TRAIL-R1 / death_receptor_4 protein : different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin .
12927928	0	death_receptor_4	127,143	TRAIL-R1	118,126	death receptor 4	TRAIL-R1	8797	8797	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Hepatitis_B_virus enhances tumor necrosis factor-related apoptosis-inducing ligand -LRB- TRAIL -RRB- cytotoxicity by increasing TRAIL-R1 / death_receptor_4 expression .
17914579	0	death_receptor_4	33,49	TRAIL-R1	24,32	death receptor 4	TRAIL-R1	8797	8797	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|dep|protein	Glycosylation modulates TRAIL-R1 / death_receptor_4 protein : different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin .
12082627	0	death_receptor_4	24,40	activator_protein_1	57,76	death receptor 4	activator protein 1	8797	3726	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Evidence that the human death_receptor_4 is regulated by activator_protein_1 .
15289308	0	death_receptor_4	16,32	p53	0,3	death receptor 4	p53	8797	7157	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	p53 upregulates death_receptor_4 expression through an intronic p53 binding site .
15289308	0	death_receptor_4	16,32	p53	64,67	death receptor 4	p53	8797	7157	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nmod|site site|compound|END_ENTITY	p53 upregulates death_receptor_4 expression through an intronic p53 binding site .
23261452	0	death_receptor_5	118,134	CHOP	73,77	death receptor 5	CHOP	8795	1649	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP - and p38 MAPK-mediated up-regulation of death_receptor_5 in malignant_glioma .
14691451	0	death_receptor_5	39,55	MG132	21,26	death receptor 5	MG132	8795	875581(Tax:243273)	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Proteasome inhibitor MG132 upregulates death_receptor_5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and - deficient cells .
15994939	0	death_receptor_5	35,51	MG132	21,26	death receptor 5	MG132	8795	875581(Tax:243273)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Proteasome inhibitor MG132 induces death_receptor_5 through CCAAT/enhancer-binding _ protein_homologous_protein .
25502339	0	death_receptor_5	82,98	TRAIL	64,69	death receptor 5	TRAIL	8795	8743	Gene	Gene	inducing|dobj|START_ENTITY END_ENTITY|advcl|inducing	Parthenolide enhances sensitivity of colorectal_cancer cells to TRAIL by inducing death_receptor_5 and promotes TRAIL-induced apoptosis .
11696376	0	death_receptor_5	67,83	TRAIL-R2	84,92	death receptor 5	TRAIL-R2	8795	8795	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Promoter structure and transcription initiation sites of the human death_receptor_5 / TRAIL-R2 gene .
15208660	0	death_receptor_5	42,58	TRAIL-R2	59,67	death receptor 5	TRAIL-R2	8795	8795	Gene	Gene	apoptosis|dep|START_ENTITY apoptosis|compound|END_ENTITY	Histone deacetylase inhibitors upregulate death_receptor_5 / TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant_tumor cells .
17645780	0	death_receptor_5	31,47	TRAIL-R2	48,56	death receptor 5	TRAIL-R2	8795	8795	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Lipoxygenase inhibitors induce death_receptor_5 / TRAIL-R2 expression and sensitize malignant_tumor cells to TRAIL-induced apoptosis .
25506265	0	death_receptor_5	16,32	caspase_8	51,60	death receptor 5	caspase 8	8795	841	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of death_receptor_5 and activation of caspase_8 / 3 play a critical role in ergosterol_peroxide induced apoptosis in DU 145 prostate_cancer cells .
15964798	0	death_receptor_5	56,72	histone_deacetylase_1	94,115	death receptor 5	histone deacetylase 1	8795	3065	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcription factor NF-kappaB differentially regulates death_receptor_5 expression involving histone_deacetylase_1 .
24188478	0	death_receptor_5	116,132	tumor_necrosis_factor_related_apoptosis-inducing_ligand	40,95	death receptor 5	tumor necrosis factor related apoptosis-inducing ligand	8795	8743	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Cariporide sensitizes leukemic cells to tumor_necrosis_factor_related_apoptosis-inducing_ligand by up-regulation of death_receptor_5 via endoplasmic reticulum stress-CCAAT/enhancer _ binding_protein_homologous_protein dependent mechanism .
7901140	0	debrisoquine_4-hydroxylase	28,54	CYP2D6	56,62	debrisoquine 4-hydroxylase	CYP2D6	1565	1565	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	DNA haplotype dependency of debrisoquine_4-hydroxylase -LRB- CYP2D6 -RRB- expression among extensive metabolisers .
14530374	0	decay-accelerating_factor	28,53	CD55	55,59	decay-accelerating factor	CD55	1604	1604	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Antiadhesive role of apical decay-accelerating_factor -LRB- CD55 -RRB- in human neutrophil transmigration across mucosal_epithelia .
17167176	0	decay-accelerating_factor	29,54	CD55	56,60	decay-accelerating factor	CD55	1604	1604	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression and action of decay-accelerating_factor -LRB- CD55 -RRB- in human malignancies and cancer therapy .
7687624	0	decay-accelerating_factor	14,39	CD55	41,45	decay-accelerating factor	CD55	1604	1604	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of decay-accelerating_factor -LRB- CD55 -RRB- of the complement system on human spermatozoa .
9565358	0	decay-accelerating_factor	27,52	CD55	54,58	decay-accelerating factor	CD55	1604	1604	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Up-regulated expression of decay-accelerating_factor -LRB- CD55 -RRB- confers increased complement resistance to sprouting neural cells .
10850450	0	decay-accelerating_factor	49,74	CD59	0,4	decay-accelerating factor	CD59	1604	25407(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	CD59 expressed on a tumor cell surface modulates decay-accelerating_factor expression and enhances tumor growth in a rat model of human neuroblastoma .
10540231	0	decay-accelerating_factor	96,121	CD97	37,41	decay-accelerating factor	CD97	13136(Tax:10090)	26364(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating_factor -LRB- DAF , CD55 -RRB- .
11683962	0	decay-accelerating_factor	45,70	DAF	72,75	decay-accelerating factor	DAF	13136(Tax:10090)	13136(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Tissue distribution of products of the mouse decay-accelerating_factor -LRB- DAF -RRB- genes .
11528371	0	decay-accelerating_factor	46,71	Epidermal_growth_factor	0,23	decay-accelerating factor	Epidermal growth factor	1604	1950	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epidermal_growth_factor induces expression of decay-accelerating_factor in human colonic_cancer cells via the mitogen-activated protein kinase pathway .
11889210	0	decay-accelerating_factor	92,117	HB-EGF	43,49	decay-accelerating factor	HB-EGF	1604	1839	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	In vivo and in vitro evidence suggest that HB-EGF regulates endometrial expression of human decay-accelerating_factor .
11564806	0	decay-accelerating_factor	34,59	Intestinal_trefoil_factor	0,25	decay-accelerating factor	Intestinal trefoil factor	1604	7033	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Intestinal_trefoil_factor induces decay-accelerating_factor expression and enhances the protective activities against complement activation in intestinal epithelial cells .
10219599	0	decay-accelerating_factor	60,85	LPS-binding_protein	29,48	decay-accelerating factor	LPS-binding protein	1604	3929	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the 80-kDa LPS-binding_protein -LRB- LMP80 -RRB- as decay-accelerating_factor -LRB- DAF , CD55 -RRB- .
11023512	0	decay-accelerating_factor	13,38	protease-activated_receptor_1	61,90	decay-accelerating factor	protease-activated receptor 1	1604	2149	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Induction of decay-accelerating_factor by thrombin through a protease-activated_receptor_1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury .
17530719	0	decay-accelerating_factor_1	22,49	CD4	53,56	decay-accelerating factor 1	CD4	13136(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Reduced expression of decay-accelerating_factor_1 on CD4 + T cells in murine systemic_autoimmune_disease .
24703255	0	decay_accelerating_factor	56,81	CD55	83,87	decay accelerating factor	CD55	13136(Tax:10090)	13136(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The effects of prednisone and steroid-sparing agents on decay_accelerating_factor -LRB- CD55 -RRB- expression : implications in myasthenia_gravis .
8843027	0	decay_accelerating_factor	32,57	nerve_growth_factor	68,87	decay accelerating factor	nerve growth factor	1604	4803	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Activation of the gene encoding decay_accelerating_factor following nerve_growth_factor treatment of sensory neurons is mediated by promoter sequences within 206 bases of the transcriptional start site .
8275950	0	decidual_prolactin	72,90	Tumor_necrosis_factor-alpha	0,27	decidual prolactin	Tumor necrosis factor-alpha	5617	7124	Gene	Gene	synthesis|nmod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits the synthesis and release of human decidual_prolactin .
19937567	0	decidual_protein_induced_by_progesterone	31,71	DEPP	73,77	decidual protein induced by progesterone	DEPP	213393(Tax:10090)	213393(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Insulin-mediated regulation of decidual_protein_induced_by_progesterone -LRB- DEPP -RRB- in adipose tissue and liver .
1431141	0	decorin	17,24	C1q	31,34	decorin	C1q	1634	712	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The proteoglycan decorin binds C1q and inhibits the activity of the C1 complex .
22363530	0	decorin	45,52	HSP90B1	70,77	decorin	HSP90B1	1634	7184	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Proteomic analyses reveal high expression of decorin and endoplasmin -LRB- HSP90B1 -RRB- are associated with breast_cancer metastasis and decreased survival .
21360479	0	decorin	24,31	KIP2	40,44	decorin	KIP2	1634	1028	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of decorin and p57 -LRB- KIP2 -RRB- correlates with poor survival and lymphatic metastasis in lung_cancer patients .
16964650	0	decorin	46,53	TGF-beta1	57,66	decorin	TGF-beta1	1634	7040	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	-LSB- The antagonistic effect of recombinant human decorin on TGF-beta1 stimulation of fibroblasts in collagen lattices -RSB- .
14964452	0	decorin	68,75	biglycan	25,33	decorin	biglycan	1634	633	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Glomerular expression of biglycan and decorin and urinary levels of decorin in primary glomerular_disease .
9089489	0	decorin	45,52	interleukin-1_beta	23,41	decorin	interleukin-1 beta	1634	3553	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of recombinant interleukin-1_beta on decorin gene expression in human periodontal ligament fibroblast and its possible transcriptional regulation .
21699018	0	decoy_receptor-3	20,36	DcR3	38,42	decoy receptor-3	DcR3	8771	8771	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of death decoy_receptor-3 -LRB- DcR3 -RRB- in human breast_cancer and its functional effects on breast_cancer cells in vitro .
10632670	0	decoy_receptor_3	23,39	DcR3	41,45	decoy receptor 3	DcR3	8771	8771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Over-expression of the decoy_receptor_3 -LRB- DcR3 -RRB- gene in peripheral blood mononuclear cells -LRB- PBMC -RRB- derived from silicosis patients .
23846297	0	decoy_receptor_3	13,29	DcR3	31,35	decoy receptor 3	DcR3	8771	8771	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Silencing of decoy_receptor_3 -LRB- DcR3 -RRB- expression by siRNA in pancreatic_carcinoma cells induces Fas_ligand-mediated apoptosis in vitro and in vivo .
26062966	0	decoy_receptor_3	14,30	DcR3	32,36	decoy receptor 3	DcR3	8771	8771	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	The serologic decoy_receptor_3 -LRB- DcR3 -RRB- levels are associated with slower disease progression in HIV-1 / AIDS patients .
17301127	0	decoy_receptor_3	59,75	Rta	43,46	decoy receptor 3	Rta	8771	116535	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Epstein-Barr_virus transcription activator Rta upregulates decoy_receptor_3 expression by binding to its promoter .
18818389	0	dectin-1	39,47	Syk	48,51	dectin-1	Syk	56644(Tax:10090)	20963(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Stimulation of dendritic cells via the dectin-1 / Syk pathway allows priming of cytotoxic T-cell responses .
23817424	0	dectin-1	102,110	Syk	111,114	dectin-1	Syk	64581	6850	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Corticosteroids block autophagy protein recruitment in Aspergillus_fumigatus phagosomes via targeting dectin-1 / Syk kinase signaling .
25976676	0	dedicator_of_cytokinesis_6	10,36	DOCK6	38,43	dedicator of cytokinesis 6	DOCK6	508023(Tax:9913)	508023(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect in dedicator_of_cytokinesis_6 -LRB- DOCK6 -RRB- on steroid production in theca cells of follicular_cysts .
9065698	0	deep_orange	34,45	dor	47,50	deep orange	dor	31118(Tax:7227)	31118(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the deep_orange -LRB- dor -RRB- gene of Drosophila_melanogaster .
11929961	0	defective_kernel_1	4,22	dek1	24,28	defective kernel 1	dek1	542509(Tax:4577)	542509(Tax:4577)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The defective_kernel_1 -LRB- dek1 -RRB- gene required for aleurone cell development in the endosperm of maize grains encodes a membrane protein of the calpain gene superfamily .
24086683	0	defensin_5	27,37	CD4	49,52	defensin 5	CD4	1670	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Anti-HIV activity of human defensin_5 in primary CD4 + T cells under serum-deprived conditions is a consequence of defensin-mediated cytotoxicity .
11273652	0	deg-3	24,29	des-2	30,35	deg-3	des-2	3565200(Tax:6239)	179574(Tax:6239)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Characterization of the deg-3 / des-2 receptor : a nicotinic acetylcholine receptor that mutates to cause neuronal_degeneration .
15286152	0	deiodinase_type_2	34,51	DIO2	28,32	deiodinase type 2	DIO2	1734	1734	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Positive association of the DIO2 -LRB- deiodinase_type_2 -RRB- gene with mental_retardation in the iodine-deficient areas of China .
11929961	0	dek1	24,28	defective_kernel_1	4,22	dek1	defective kernel 1	542509(Tax:4577)	542509(Tax:4577)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The defective_kernel_1 -LRB- dek1 -RRB- gene required for aleurone cell development in the endosperm of maize grains encodes a membrane protein of the calpain gene superfamily .
22553202	0	deleted_in_breast_cancer_1	8,34	DBC1	36,40	deleted in breast cancer 1	DBC1	57805	57805	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Role of deleted_in_breast_cancer_1 -LRB- DBC1 -RRB- protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase .
24400119	0	deleted_in_colorectal_cancer	39,67	DCC	69,72	deleted in colorectal cancer	DCC	13176(Tax:10090)	13176(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Defining the ligand specificity of the deleted_in_colorectal_cancer -LRB- DCC -RRB- receptor .
7553661	0	deleted_in_colorectal_cancer	4,32	DCC	34,37	deleted in colorectal cancer	DCC	1630	1630	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The deleted_in_colorectal_cancer -LRB- DCC -RRB- gene : a candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules .
7813784	0	deleted_in_colorectal_cancer	33,61	DCC	63,66	deleted in colorectal cancer	DCC	378529(Tax:8355)	378529(Tax:8355)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of a homologue of the deleted_in_colorectal_cancer -LRB- DCC -RRB- gene in the nervous system of developing Xenopus embryos .
8044801	0	deleted_in_colorectal_cancer	43,71	DCC	73,76	deleted in colorectal cancer	DCC	1630	1630	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression and alternative splicing of the deleted_in_colorectal_cancer -LRB- DCC -RRB- gene in normal and malignant tissues .
9950216	0	deleted_in_colorectal_cancer	27,55	Netrin-1	0,8	deleted in colorectal cancer	Netrin-1	1630	9423	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	Netrin-1 : interaction with deleted_in_colorectal_cancer -LRB- DCC -RRB- and alterations in brain_tumors and neuroblastomas .
20600027	0	deleted_in_liver_cancer_1	23,48	Akt	0,3	deleted in liver cancer 1	Akt	50768(Tax:10090)	11651(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Akt phosphorylation of deleted_in_liver_cancer_1 abrogates its suppression of liver_cancer tumorigenesis and metastasis .
18981889	0	deleted_in_liver_cancer_1	22,47	DLC1	54,58	deleted in liver cancer 1	DLC1	10395	10395	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the deleted_in_liver_cancer_1 gene , DLC1 , as a candidate meningioma_tumor suppressor .
21969587	0	deleted_in_liver_cancer_1	21,46	DLC1	48,52	deleted in liver cancer 1	DLC1	10395	10395	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Full activity of the deleted_in_liver_cancer_1 -LRB- DLC1 -RRB- tumor suppressor depends on an LD-like motif that binds talin and focal_adhesion_kinase -LRB- FAK -RRB- .
16624504	0	deleted_in_malignant_brain_tumors_1	42,77	DMBT1	84,89	deleted in malignant brain tumors 1	DMBT1	1755	1755	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the porcine deleted_in_malignant_brain_tumors_1 gene -LRB- DMBT1 -RRB- .
8188255	0	delta-aminolevulinate_dehydratase	6,39	ALAD	41,45	delta-aminolevulinate dehydratase	ALAD	210	210	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human delta-aminolevulinate_dehydratase -LRB- ALAD -RRB- gene : structure and alternative splicing of the erythroid and housekeeping mRNAs .
9806796	0	delta-aminolevulinate_synthase	17,47	Insulin	0,7	delta-aminolevulinate synthase	Insulin	211	3630	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Insulin inhibits delta-aminolevulinate_synthase gene expression in rat hepatocytes and human hepatoma cells .
15587989	0	delta-aminolevulinic_acid_dehydratase	22,59	ALAD	61,65	delta-aminolevulinic acid dehydratase	ALAD	100549846	100549846	Gene	Gene	analysis|nmod|START_ENTITY END_ENTITY|nsubj|analysis	Molecular analysis of delta-aminolevulinic_acid_dehydratase -LRB- ALAD -RRB- gene polymorphism in a Turkish population .
17966070	0	delta-aminolevulinic_acid_dehydratase	20,57	ALAD	59,63	delta-aminolevulinic acid dehydratase	ALAD	210	210	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between delta-aminolevulinic_acid_dehydratase -LRB- ALAD -RRB- polymorphism and blood lead levels : a meta-regression analysis .
8916973	0	delta-globin	14,26	erythroid_Krupple-like_factor	46,75	delta-globin	erythroid Krupple-like factor	3039	10661	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of delta-globin gene expression by erythroid_Krupple-like_factor : a potential approach for gene therapy of sickle_cell_disease .
15289021	0	delta-like	18,28	Dlk	30,33	delta-like	Dlk	7786	7786	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of delta-like -LRB- Dlk -RRB- in a subset of myelodysplastic_syndrome bone marrow trephines .
23946446	0	delta-like_1_homolog	13,33	DLK1	35,39	delta-like 1 homolog	DLK1	13386(Tax:10090)	13386(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Dual role of delta-like_1_homolog -LRB- DLK1 -RRB- in skeletal muscle development and adult muscle regeneration .
19413639	0	delta-like_ligand_4	62,81	DLL4	83,87	delta-like ligand 4	DLL4	54567	54567	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Nuclear and membrane expression of the angiogenesis regulator delta-like_ligand_4 -LRB- DLL4 -RRB- in normal and malignant human tissues .
12270273	0	delta7-sterol_reductase	33,56	DHCR7	58,63	delta7-sterol reductase	DHCR7	1717	1717	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two novel mutations of the human delta7-sterol_reductase -LRB- DHCR7 -RRB- gene in children with Smith-Lemli-Opitz_syndrome .
18622689	0	deltaEF1	24,32	ZEB1	18,22	deltaEF1	ZEB1	6935	6935	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Expression of the ZEB1 -LRB- deltaEF1 -RRB- transcription factor in human : additional insights .
2185466	0	delta_1-crystallin	35,53	insulin-like_growth_factor_I	62,90	delta 1-crystallin	insulin-like growth factor I	396498(Tax:9031)	100327329(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional stimulation of the delta_1-crystallin gene by insulin-like_growth_factor_I and insulin requires DNA cis elements in chicken .
12107170	0	delta_EF1	146,155	Upstream_stimulatory_factor	0,27	delta EF1	Upstream stimulatory factor	6935	7391	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Upstream_stimulatory_factor -LRB- USF -RRB- is recruited into a steroid hormone-triggered regulatory circuit by the estrogen-inducible transcription factor delta_EF1 .
15153675	0	delta_like_3	65,77	Dll3	79,83	delta like 3	Dll3	13389(Tax:10090)	13389(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	New mutant mouse with skeletal_deformities caused by mutation in delta_like_3 -LRB- Dll3 -RRB- gene .
11471858	0	demethylase	4,15	lung_resistance_protein	43,66	demethylase	lung resistance protein	8932	9961	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	DNA demethylase expression correlates with lung_resistance_protein expression in common epithelial ovarian_cancers .
17251388	0	dendrin	80,87	ehd3	89,93	dendrin	ehd3	13199(Tax:10090)	57440(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	dendrin	80,87	plekhh2	103,110	dendrin	plekhh2	13199(Tax:10090)	213556(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	dendrin	80,87	sh2d4a	95,101	dendrin	sh2d4a	13199(Tax:10090)	72281(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
19879650	0	dendritic_cell-specific_ICAM-3-grabbing_non-integrin	23,75	DC-SIGN	77,84	dendritic cell-specific ICAM-3-grabbing non-integrin	DC-SIGN	30835	30835	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Epitope mapping on the dendritic_cell-specific_ICAM-3-grabbing_non-integrin -LRB- DC-SIGN -RRB- pathogen-attachment factor .
20667443	0	dendritic_cell-specific_ICAM-3-grabbing_nonintegrin	24,75	DC-SIGN	77,84	dendritic cell-specific ICAM-3-grabbing nonintegrin	DC-SIGN	30835	30835	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	An assay for functional dendritic_cell-specific_ICAM-3-grabbing_nonintegrin -LRB- DC-SIGN -RRB- inhibitors of human dendritic_cell_adhesion .
25182705	0	dendritic_cell-specific_intercellular_adhesion_molecule-3-grabbing_nonintegrin	18,96	b2-microglobulin	156,172	dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin	b2-microglobulin	30835	3135	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Low expression of dendritic_cell-specific_intercellular_adhesion_molecule-3-grabbing_nonintegrin in non-Hodgkin_lymphoma and a significant correlation with b2-microglobulin .
23209320	0	deneddylase-1	35,48	SENP8	49,54	deneddylase-1	SENP8	123228	123228	Gene	Gene	role|nmod|START_ENTITY role|parataxis|END_ENTITY	Central role for endothelial human deneddylase-1 / SENP8 in fine-tuning the vascular inflammatory response .
11042112	0	dentatorubral-pallidoluysian_atrophy	28,64	DRPLA	66,71	dentatorubral-pallidoluysian atrophy	DRPLA	1822	1822	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Aberrant phosphorylation of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein complex in brain tissue .
12235796	0	dentatorubral-pallidoluysian_atrophy	46,82	DRPLA	84,89	dentatorubral-pallidoluysian atrophy	DRPLA	13498(Tax:10090)	13498(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Molecular mechanisms of neurodegeneration in dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- -RSB- .
9109905	0	dentatorubral-pallidoluysian_atrophy	68,104	DRPLA	106,111	dentatorubral-pallidoluysian atrophy	DRPLA	1822	1822	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Homozygosity for an allele carrying intermediate CAG repeats in the dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- gene results in spastic_paraplegia .
9143016	0	dentatorubral-pallidoluysian_atrophy	14,50	DRPLA	52,57	dentatorubral-pallidoluysian atrophy	DRPLA	1822	1822	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Expression of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- proteins in patients .
9705838	0	dentatorubral-pallidoluysian_atrophy	37,73	DRPLA	75,80	dentatorubral-pallidoluysian atrophy	DRPLA	1822	1822	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Intracellular aggregate formation of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein with the extended polyglutamine .
9735324	0	dentatorubral-pallidoluysian_atrophy	56,92	DRPLA	94,99	dentatorubral-pallidoluysian atrophy	DRPLA	1822	1822	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expanded glutamine repeat enhances complex formation of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein in human brains .
9878517	0	dentatorubral-pallidoluysian_atrophy	32,68	DRPLA	70,75	dentatorubral-pallidoluysian atrophy	DRPLA	29515(Tax:10116)	1822	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Different complex formations of dentatorubral-pallidoluysian_atrophy -LRB- DRPLA -RRB- protein in human and rat neurons .
8825056	0	dentatorubral_pallidoluysian_atrophy	95,131	DRPLA	133,138	dentatorubral pallidoluysian atrophy	DRPLA	1822	1822	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Benign adult familial myoclonus_epilepsy -LRB- BAFME -RRB- : an autosomal dominant form not linked to the dentatorubral_pallidoluysian_atrophy -LRB- DRPLA -RRB- gene .
9177774	0	dentin_matrix_acidic_phosphoprotein_1	70,107	DMP1	109,113	dentin matrix acidic phosphoprotein 1	DMP1	1758	1758	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Elucidation of the sequence and the genomic organization of the human dentin_matrix_acidic_phosphoprotein_1 -LRB- DMP1 -RRB- gene : exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II .
19796717	0	dentin_matrix_protein-1	26,49	DMP-1	51,56	dentin matrix protein-1	DMP-1	1758	1758	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Identification of a novel dentin_matrix_protein-1 -LRB- DMP-1 -RRB- mutation and dental_anomalies in a kindred with autosomal recessive hypophosphatemia .
10744713	0	dentin_matrix_protein_1	36,59	DMP1	61,65	dentin matrix protein 1	DMP1	25312(Tax:10116)	25312(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of rat dentin_matrix_protein_1 -LRB- DMP1 -RRB- gene and its 5 ' - upstream region .
12470941	0	dentin_matrix_protein_1	15,38	DMP1	40,44	dentin matrix protein 1	DMP1	1758	1758	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Utility of the dentin_matrix_protein_1 -LRB- DMP1 -RRB- gene for resolving mammalian intraordinal phylogenetic relationships .
12489182	0	dentin_matrix_protein_1	30,53	DMP1	55,59	dentin matrix protein 1	DMP1	25312(Tax:10116)	25312(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of dentin_matrix_protein_1 -LRB- DMP1 -RRB- by AP-1 -LRB- c-fos/c-jun -RRB- factors .
12733719	0	dentin_matrix_protein_1	30,53	DMP1	55,59	dentin matrix protein 1	DMP1	13406(Tax:10090)	13406(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mechanical loading stimulates dentin_matrix_protein_1 -LRB- DMP1 -RRB- expression in osteocytes in vivo .
15268908	0	dentin_matrix_protein_1	14,37	DMP1	39,43	dentin matrix protein 1	DMP1	1758	1758	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of dentin_matrix_protein_1 -LRB- DMP1 -RRB- during fracture healing .
15316863	0	dentin_matrix_protein_1	14,37	DMP1	39,43	dentin matrix protein 1	DMP1	13406(Tax:10090)	13406(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of dentin_matrix_protein_1 -LRB- DMP1 -RRB- in nonmineralized tissues .
25158192	0	dentin_matrix_protein_1	30,53	DMP1	55,59	dentin matrix protein 1	DMP1	25312(Tax:10116)	25312(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of dentin_matrix_protein_1 -LRB- DMP1 -RRB- in odontoblasts and osteoblasts .
18757373	0	dentin_matrix_protein_1	71,94	GRP-78	40,46	dentin matrix protein 1	GRP-78	13406(Tax:10090)	14828(Tax:10090)	Gene	Gene	endocytosis|nmod|START_ENTITY mediates|dobj|endocytosis mediates|nsubj|END_ENTITY	Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin_matrix_protein_1 .
9541230	0	dentin_sialophosphoprotein	29,55	DSPP	57,61	dentin sialophosphoprotein	DSPP	1834	1834	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Refined mapping of the human dentin_sialophosphoprotein -LRB- DSPP -RRB- gene within the critical dentinogenesis_imperfecta_type_II and dentin_dysplasia_type_II loci .
16679514	0	dentin_sialophosphoprotein	34,60	Dentin_matrix_protein_1	0,23	dentin sialophosphoprotein	Dentin matrix protein 1	1834	1758	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Dentin_matrix_protein_1 regulates dentin_sialophosphoprotein gene transcription during early odontoblast differentiation .
9545272	0	dentin_sialophosphoprotein	78,104	Dspp	106,110	dentin sialophosphoprotein	Dspp	666279(Tax:10090)	666279(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization , chromosomal mapping , and promoter analysis of the mouse dentin_sialophosphoprotein -LRB- Dspp -RRB- gene , which codes for both dentin sialoprotein and dentin phosphoprotein .
17286598	0	dentin_sialophosphoprotein	17,43	Wnt10a	0,6	dentin sialophosphoprotein	Wnt10a	666279(Tax:10090)	22409(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Wnt10a regulates dentin_sialophosphoprotein mRNA expression and possibly links odontoblast differentiation and tooth morphogenesis .
20637175	0	deoxycytidine_kinase	49,69	Casein_kinase_1delta	0,20	deoxycytidine kinase	Casein kinase 1delta	1633	1453	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Casein_kinase_1delta activates human recombinant deoxycytidine_kinase by Ser-74 phosphorylation , but is not involved in the in vivo regulation of its activity .
2989022	0	deoxycytidine_kinase	79,99	T-lymphoblast-specific_nucleoside_kinase	0,40	deoxycytidine kinase	T-lymphoblast-specific nucleoside kinase	1633	25987	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|dep|characterization	T-lymphoblast-specific_nucleoside_kinase : characterization and comparison with deoxycytidine_kinase .
12142097	0	deoxycytidine_kinase	8,28	dCK	30,33	deoxycytidine kinase	dCK	13178(Tax:10090)	39429(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Role of deoxycytidine_kinase -LRB- dCK -RRB- activity in gemcitabine 's radioenhancement in mice and human cell lines in vitro .
15520873	0	deoxycytidine_kinase	21,41	dCK	43,46	deoxycytidine kinase	dCK	1633	43828(Tax:7227)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	-LSB- Special function of deoxycytidine_kinase -LRB- dCK -RRB- in the activation of chemotherapeutic nucleoside analogs and in the inhibition of cell proliferation -RSB- .
7874009	0	deoxycytidine_kinase	22,42	dCK	44,47	deoxycytidine kinase	dCK	1633	39429(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Low expression of the deoxycytidine_kinase -LRB- dCK -RRB- gene in a 1-beta-D-arabinofuranosylcytosine-resistant human leukemic cell line KY-Ra .
9869205	0	deoxycytidine_kinase	14,34	dCK	102,105	deoxycytidine kinase	dCK	1633	39429(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY Expression|nmod|gene Expression|dep|expression expression|nmod|gene gene|compound|END_ENTITY	Expression of deoxycytidine_kinase -LRB- dCK -RRB- gene in leukemic cells in childhood : decreased expression of dCK gene in relapsed leukemia .
9869205	0	deoxycytidine_kinase	14,34	dCK	36,39	deoxycytidine kinase	dCK	1633	39429(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of deoxycytidine_kinase -LRB- dCK -RRB- gene in leukemic cells in childhood : decreased expression of dCK gene in relapsed leukemia .
7541096	0	deoxycytidine_kinase	33,53	dck	55,58	deoxycytidine kinase	dck	79127(Tax:10116)	79127(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	De novo induced mutations in the deoxycytidine_kinase -LRB- dck -RRB- gene in rat leukemic clonal cell lines confer resistance to cytarabine -LRB- AraC -RRB- and 5-aza-2 ' - deoxycytidine -LRB- DAC -RRB- .
7543292	0	deoxycytidine_kinase	184,204	dck	206,209	deoxycytidine kinase	dck	79127(Tax:10116)	79127(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	In vitro-induced resistance to the deoxycytidine analogues cytarabine -LRB- AraC -RRB- and 5-aza-2 ' - deoxycytidine -LRB- DAC -RRB- in a rat model for acute_myeloid_leukemia is mediated by mutations in the deoxycytidine_kinase -LRB- dck -RRB- gene .
15039063	0	deoxyhypusine_synthase	38,60	deoxyhypusine_synthase	71,93	deoxyhypusine synthase	deoxyhypusine synthase	444988(Tax:9913)	1725	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Higher activity of recombinant bovine deoxyhypusine_synthase vs. human deoxyhypusine_synthase .
15039063	0	deoxyhypusine_synthase	71,93	deoxyhypusine_synthase	38,60	deoxyhypusine synthase	deoxyhypusine synthase	1725	444988(Tax:9913)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Higher activity of recombinant bovine deoxyhypusine_synthase vs. human deoxyhypusine_synthase .
4140510	0	deoxyribonuclease_I	46,65	Actin	0,5	deoxyribonuclease I	Actin	282217(Tax:9913)	528168(Tax:9913)	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Actin is the naturally occurring inhibitor of deoxyribonuclease_I .
7789176	0	deoxyribonuclease_I	36,55	DNASE_1	62,69	deoxyribonuclease I	DNASE 1	1773	1773	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal assignment of the human deoxyribonuclease_I gene , DNASE_1 -LRB- DNL1 -RRB- , to band 16p13 .3 using the polymerase chain reaction .
21335080	0	deoxyribonuclease_I	42,61	DNaseI	63,69	deoxyribonuclease I	DNaseI	1773	1773	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Enhanced properties of discrete pulmonary deoxyribonuclease_I -LRB- DNaseI -RRB- loaded PLGA nanoparticles during encapsulation and activity determination .
16877481	0	deoxyribonuclease_I	45,64	DNase_I	66,73	deoxyribonuclease I	DNase I	1773	1773	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of Gln222Arg polymorphism in the deoxyribonuclease_I -LRB- DNase_I -RRB- gene with myocardial_infarction in Japanese patients .
7556418	0	deoxyribonuclease_I	23,42	DNase_I	44,51	deoxyribonuclease I	DNase I	13419(Tax:10090)	13419(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Tissue distribution of deoxyribonuclease_I -LRB- DNase_I -RRB- activity level in mice and its sexual dimorphism .
7762978	0	deoxyribonuclease_I	23,42	DNase_I	44,51	deoxyribonuclease I	DNase I	1773	1773	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the human deoxyribonuclease_I -LRB- DNase_I -RRB- gene : identification of the nucleotide substitution that generates its classical genetic polymorphism .
8250234	0	deoxyribonuclease_I	87,106	actin	64,69	deoxyribonuclease I	actin	282217(Tax:9913)	528168(Tax:9913)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	A fluorometric microplate-based assay of submicrogram monomeric actin by inhibition of deoxyribonuclease_I .
10567908	0	deoxyuridine_triphosphatase	14,41	dUTPase	43,50	deoxyuridine triphosphatase	dUTPase	1854	34529(Tax:7227)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of deoxyuridine_triphosphatase -LRB- dUTPase -RRB- in colorectal_tumours .
19052026	0	deoxyuridine_triphosphatase	21,48	dUTPase	50,57	deoxyuridine triphosphatase	dUTPase	1854	34529(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Higher expression of deoxyuridine_triphosphatase -LRB- dUTPase -RRB- may predict the metastasis potential of colorectal_cancer .
20842734	0	dermatan-4-sulfotransferase_1	171,200	CHST14	210,216	dermatan-4-sulfotransferase 1	CHST14	113189	113189	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Musculocontractural Ehlers-Danlos_Syndrome -LRB- former EDS type VIB -RRB- and adducted thumb clubfoot_syndrome -LRB- ATCS -RRB- represent a single clinical entity caused by mutations in the dermatan-4-sulfotransferase_1 encoding CHST14 gene .
11273652	0	des-2	30,35	deg-3	24,29	des-2	deg-3	179574(Tax:6239)	3565200(Tax:6239)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Characterization of the deg-3 / des-2 receptor : a nicotinic acetylcholine receptor that mutates to cause neuronal_degeneration .
22114190	0	desat1	33,39	desaturase	16,26	desat1	desaturase	117369(Tax:7227)	117369(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of a desaturase gene , desat1 , in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila .
22114190	0	desaturase	16,26	desat1	33,39	desaturase	desat1	117369(Tax:7227)	117369(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of a desaturase gene , desat1 , in neural and nonneural tissues separately affects perception and emission of sex pheromones in Drosophila .
9264259	0	desmin	69,75	EGF	11,14	desmin	EGF	13346(Tax:10090)	13645(Tax:10090)	Gene	Gene	co-expressed|nmod|START_ENTITY co-expressed|nsubjpass|END_ENTITY	TGF-alpha , EGF , and their cognate EGF receptor are co-expressed with desmin during embryonic , fetal , and neonatal myogenesis in mouse tongue development .
8439342	0	desmin	31,37	cdc2	0,4	desmin	cdc2	1674	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	cdc2 kinase phosphorylation of desmin at three serine/threonine residues in the amino-terminal head domain .
11738361	0	desmin	27,33	galectin-1	115,125	desmin	galectin-1	1674	3956	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	The muscle-specific marker desmin is expressed in a proportion of human dermal fibroblasts after their exposure to galectin-1 .
18407667	0	desmin	68,74	surfactant_protein_A	15,35	desmin	surfactant protein A	1674	653509	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of surfactant_protein_A with the intermediate filaments desmin and vimentin .
3042384	0	desmin	42,48	vimentin	32,40	desmin	vimentin	13346(Tax:10090)	22352(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY expression|dep|gene expression|nmod|END_ENTITY	Tissue-specific expression of a vimentin -- desmin hybrid gene in transgenic_mice .
8085393	0	desmin	46,52	vimentin	36,44	desmin	vimentin	1674	7431	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Immunohistochemical distribution of vimentin , desmin , glial fibrillary acidic protein and neurofilament proteins in feline tissues .
19765682	0	desmocollin-3	44,57	DSC3	59,63	desmocollin-3	DSC3	1825	1825	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A homozygous nonsense mutation in the human desmocollin-3 -LRB- DSC3 -RRB- gene underlies hereditary_hypotrichosis and recurrent skin_vesicles .
8040606	0	desmoglein_1	49,61	Dsg1	63,67	desmoglein 1	Dsg1	281131(Tax:9913)	281131(Tax:9913)	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The extracellular aminoterminal domain of bovine desmoglein_1 -LRB- Dsg1 -RRB- is recognized only by certain pemphigus foliaceus sera , whereas its intracellular domain is recognized by both pemphigus_vulgaris and pemphigus foliaceus sera .
26498522	0	desmoglein_1	44,56	LOX-1	90,95	desmoglein 1	LOX-1	1828	4973	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Oxidized low-density lipoprotein attenuated desmoglein_1 and desmocollin_2 expression via LOX-1 / Ca -LRB- 2 + -RRB- / PKC-b signal in human umbilical vein endothelial cells .
26043694	0	desmoglein_1	15,27	Sgk1	0,4	desmoglein 1	Sgk1	13510(Tax:10090)	20393(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Sgk1 regulates desmoglein_1 expression levels in oligodendrocytes in the mouse corpus callosum after chronic stress exposure .
16286477	0	desmoglein_1	50,62	caspase-3	74,83	desmoglein 1	caspase-3	1828	836	Gene	Gene	target|nsubj|START_ENTITY target|amod|END_ENTITY	The differentiation-dependent desmosomal cadherin desmoglein_1 is a novel caspase-3 target that regulates apoptosis in keratinocytes .
10949543	0	desmoglein_3	21,33	Dsg3	40,44	desmoglein 3	Dsg3	13512(Tax:10090)	13512(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the mouse desmoglein_3 gene -LRB- Dsg3 -RRB- : interspecies conservation within the cadherin superfamily .
18343367	0	desmoglein_3	113,125	P120-catenin	0,12	desmoglein 3	P120-catenin	1830	1500	Gene	Gene	site|nmod|START_ENTITY identification|nmod|site partner|dep|identification partner|nsubj|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
18343367	0	desmoglein_3	24,36	P120-catenin	0,12	desmoglein 3	P120-catenin	1830	1500	Gene	Gene	partner|amod|START_ENTITY partner|nsubj|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
12648224	0	desmoglein_3	53,65	desmoglein_3	69,81	desmoglein 3	desmoglein 3	13512(Tax:10090)	13512(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Suppression of the immune response against exogenous desmoglein_3 in desmoglein_3 knockout mice : an implication for gene therapy .
12648224	0	desmoglein_3	69,81	desmoglein_3	53,65	desmoglein 3	desmoglein 3	13512(Tax:10090)	13512(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Suppression of the immune response against exogenous desmoglein_3 in desmoglein_3 knockout mice : an implication for gene therapy .
18343367	0	desmoglein_3	113,125	p120-catenin	80,92	desmoglein 3	p120-catenin	1830	1500	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
18343367	0	desmoglein_3	24,36	p120-catenin	80,92	desmoglein 3	p120-catenin	1830	1500	Gene	Gene	partner|amod|START_ENTITY partner|dep|identification identification|nmod|site site|amod|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
21495994	0	desmoglein_4	77,89	DSG4	91,95	desmoglein 4	DSG4	147409	147409	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein_4 -LRB- DSG4 -RRB- gene .
12588962	0	desmoyokin	39,49	AHNAK	32,37	desmoyokin	AHNAK	66395(Tax:10090)	66395(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the giant protein AHNAK -LRB- desmoyokin -RRB- in muscle and lining epithelial cells .
21345788	0	diabetes-associated_protein_in_insulin-sensitive_tissue	20,75	DAPIT	13,18	diabetes-associated protein in insulin-sensitive tissue	DAPIT	84833	84833	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Knockdown of DAPIT -LRB- diabetes-associated_protein_in_insulin-sensitive_tissue -RRB- results in loss of ATP synthase in mitochondria .
23919406	0	diacylglycerol_O-acyltransferase_1	50,84	DGAT1	86,91	diacylglycerol O-acyltransferase 1	DGAT1	8694	8694	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Current status of the research and development of diacylglycerol_O-acyltransferase_1 -LRB- DGAT1 -RRB- inhibitors .
17477860	0	diacylglycerol_O-acyltransferase_homolog_2	47,89	DGAT2	96,101	diacylglycerol O-acyltransferase homolog 2	DGAT2	84649	84649	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation screen and association studies in the diacylglycerol_O-acyltransferase_homolog_2 gene -LRB- DGAT2 -RRB- , a positional candidate gene for early onset obesity on chromosome 11q13 .
11171174	0	diacylglycerol_acyltransferase	27,57	DGAT	59,63	diacylglycerol acyltransferase	DGAT	8694	8694	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Differential expression of diacylglycerol_acyltransferase -LRB- DGAT -RRB- genes in olive tissues .
18631243	0	diacylglycerol_acyltransferase_1	54,86	DGAT1	88,93	diacylglycerol acyltransferase 1	DGAT1	816464(Tax:3702)	816464(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of an acyl-CoA-dependent diacylglycerol_acyltransferase_1 -LRB- DGAT1 -RRB- gene from Tropaeolum majus , and a study of the functional motifs of the DGAT protein using site-directed mutagenesis to modify enzyme activity and oil content .
23735282	0	diacylglycerol_acyltransferase_1	52,84	DGAT1	86,91	diacylglycerol acyltransferase 1	DGAT1	13350(Tax:10090)	13350(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Evaluation of thiazole containing biaryl analogs as diacylglycerol_acyltransferase_1 -LRB- DGAT1 -RRB- inhibitors .
26804232	0	diacylglycerol_acyltransferase_1	34,66	DGAT1	68,73	diacylglycerol acyltransferase 1	DGAT1	8694	8694	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of diamide compounds as diacylglycerol_acyltransferase_1 -LRB- DGAT1 -RRB- inhibitors .
15671038	0	diacylglycerol_acyltransferase_2	88,120	DGAT2	122,127	diacylglycerol acyltransferase 2	DGAT2	158833	158833	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of two novel human acyl-CoA wax alcohol acyltransferases : members of the diacylglycerol_acyltransferase_2 -LRB- DGAT2 -RRB- gene superfamily .
7607687	0	diacylglycerol_kinase	40,61	DAGK	63,67	diacylglycerol kinase	DAGK	110524(Tax:10090)	110524(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Chromosomal localization of three mouse diacylglycerol_kinase -LRB- DAGK -RRB- genes : genes sharing sequence homology to the Drosophila retinal_degeneration A -LRB- rdgA -RRB- gene .
26521214	0	diacylglycerol_kinase	42,63	p53	25,28	diacylglycerol kinase	p53	1607	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of p53 and NF-kB by diacylglycerol_kinase .
14707140	0	diacylglycerol_kinase-zeta	53,79	c-src	112,117	diacylglycerol kinase-zeta	c-src	8525	6714	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Gonadotropin-releasing_hormone-induced activation of diacylglycerol_kinase-zeta and its association with active c-src .
11352924	0	diacylglycerol_kinase-zeta	39,65	gamma_1-syntrophin	15,33	diacylglycerol kinase-zeta	gamma 1-syntrophin	8525	54212	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of gamma_1-syntrophin with diacylglycerol_kinase-zeta .
8585934	0	diacylglycerol_kinase_3	34,57	DAGK3	59,64	diacylglycerol kinase 3	DAGK3	1608	1608	Gene	Gene	Localisation|nmod|START_ENTITY Localisation|appos|END_ENTITY	Localisation of the gene encoding diacylglycerol_kinase_3 -LRB- DAGK3 -RRB- to human chromosome 3q27-28 and mouse chromosome 16 .
11719522	0	diacylglycerol_kinase_beta	52,78	DGKbeta	80,87	diacylglycerol kinase beta	DGKbeta	1607	1607	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the human diacylglycerol_kinase_beta -LRB- DGKbeta -RRB- gene : alternative splicing generates DGKbeta isotypes with different properties .
26898284	0	diacylglycerol_o-acyltransferase_1	15,49	DGAT1	51,56	diacylglycerol o-acyltransferase 1	DGAT1	282609(Tax:9913)	282609(Tax:9913)	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Effects of the diacylglycerol_o-acyltransferase_1 -LRB- DGAT1 -RRB- K232A polymorphism on fatty_acid , protein , and mineral composition of dairy cattle milk .
2124560	0	diamine_oxidase	21,36	DAO	38,41	diamine oxidase	DAO	65029(Tax:10116)	65029(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of intestinal diamine_oxidase -LRB- DAO -RRB- depletion by heparin on mucosal polyamine metabolism .
2504567	0	diamine_oxidase	32,47	DAO	49,52	diamine oxidase	DAO	65029(Tax:10116)	65029(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Changes in serum and intestinal diamine_oxidase -LRB- DAO -RRB- activity after proximal enterectomy in rats .
2508450	0	diamine_oxidase	12,27	DAO	29,32	diamine oxidase	DAO	26	26	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Studies on diamine_oxidase -LRB- DAO -RRB- activity in seminal plasma -RSB- .
3134802	0	diamine_oxidase	23,38	DAO	40,43	diamine oxidase	DAO	26	26	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Large bowel tumors and diamine_oxidase -LRB- DAO -RRB- activity in patients : a new approach for risk group identification .
1529792	0	diamine_oxidase	76,91	Histaminase	0,11	diamine oxidase	Histaminase	65029(Tax:10116)	65029(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Histaminase activity in rat lung and its comparison with intestinal mucosal diamine_oxidase .
191838	0	diamine_oxidase	13,28	Histaminase	0,11	diamine oxidase	Histaminase	26	26	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Histaminase -LRB- diamine_oxidase -RRB- activity in human tumors : an expression of a mature genome .
24170570	0	diamine_oxidase	21,36	bean	52,56	diamine oxidase	bean	26	146227	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Sequence analysis of diamine_oxidase gene from fava bean and its expression related to y-aminobutyric_acid accumulation in seeds germinating under hypoxia-NaCl stress .
171575	0	diamine_oxidase	22,37	histaminase	9,20	diamine oxidase	histaminase	26	26	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Elevated histaminase -LRB- diamine_oxidase -RRB- activity in small-cell carcinoma_of_the_lung .
96300	0	diamine_oxidase	49,64	histaminase	36,47	diamine oxidase	histaminase	26	26	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of histaminase -LRB- diamine_oxidase -RRB- in decidual cells of human placenta .
98973	0	diamine_oxidase	17,32	histaminase	34,45	diamine oxidase	histaminase	26	26	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Determination of diamine_oxidase -LRB- histaminase -RRB- activity .
411497	0	diamine_oxidase	61,76	histamine-N-methyltransferase	14,43	diamine oxidase	histamine-N-methyltransferase	26	3176	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of histamine-N-methyltransferase and histaminase -LRB- diamine_oxidase -RRB- by a new histamine H2-receptor agonist , Dimaprit .
3142228	1	diamine_oxidase	108,123	spermidine_synthase	81,100	diamine oxidase	spermidine synthase	26	6723	Gene	Gene	assay|amod|START_ENTITY END_ENTITY|nmod|assay	Part I : Interference of spermidine_synthase on the diamine_oxidase activity assay using putrescine as substrate .
18922799	0	diaphanous-1	48,60	RAGE	19,23	diaphanous-1	RAGE	1729	177	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42 .
11295830	0	diaphorase_1	161,173	b5_reductase	147,159	diaphorase 1	b5 reductase	1727	1727	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular basis of recessive_congenital_methemoglobinemia , types I and II : Exon skipping and three novel missense mutations in the NADH-cytochrome b5_reductase -LRB- diaphorase_1 -RRB- gene .
1652780	0	diazepam-binding_inhibitor	60,86	DBI	88,91	diazepam-binding inhibitor	DBI	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of peripheral benzodiazepine binding sites and diazepam-binding_inhibitor -LRB- DBI -RRB- mRNA in mammary glands and dimethylbenz -LRB- a -RRB- antracene -LRB- DMBA -RRB- - induced mammary_tumors in the rat .
1791923	0	diazepam-binding_inhibitor	16,42	DBI	44,47	diazepam-binding inhibitor	DBI	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of diazepam-binding_inhibitor -LRB- DBI -RRB- mRNA in the rat brain by high resolution in situ hybridization .
8075791	0	diazepam-binding_inhibitor	18,44	acyl-CoA-binding_protein	45,69	diazepam-binding inhibitor	acyl-CoA-binding protein	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|dep|Inhibition	Inhibition by rat diazepam-binding_inhibitor / acyl-CoA-binding_protein of glucose-induced insulin secretion in the rat .
11288485	0	diazepam_binding_inhibitor	36,62	DBI	64,67	diazepam binding inhibitor	DBI	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	-LSB- Functional involvement of cerebral diazepam_binding_inhibitor -LRB- DBI -RRB- in the establishment of drug_dependence -RSB- .
11704264	0	diazepam_binding_inhibitor	10,36	DBI	38,41	diazepam binding inhibitor	DBI	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of diazepam_binding_inhibitor -LRB- DBI -RRB- on the fluid intake , preference and the taste reactivity in mice .
11757913	0	diazepam_binding_inhibitor	29,55	DBI	57,60	diazepam binding inhibitor	DBI	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cellular localization of the diazepam_binding_inhibitor -LRB- DBI -RRB- in the gastrointestinal tract of mice and its coexistence with the fatty_acid binding protein -LRB- FABP -RRB- .
14755437	0	diazepam_binding_inhibitor	35,61	DBI	63,66	diazepam binding inhibitor	DBI	1622	1622	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multiple missense mutations in the diazepam_binding_inhibitor -LRB- DBI -RRB- gene identified in schizophrenia but lack of disease association .
1723508	0	diazepam_binding_inhibitor	41,67	DBI	69,72	diazepam binding inhibitor	DBI	1622	1622	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Electrophysiological characterization of diazepam_binding_inhibitor -LRB- DBI -RRB- on GABAA receptors .
2171047	0	diazepam_binding_inhibitor	37,63	DBI	65,68	diazepam binding inhibitor	DBI	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and characterization of diazepam_binding_inhibitor -LRB- DBI -RRB- in peripheral tissues of rat .
7913213	0	diazepam_binding_inhibitor	19,45	DBI	47,50	diazepam binding inhibitor	DBI	1622	1622	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Nicotine increases diazepam_binding_inhibitor -LRB- DBI -RRB- mRNA in primary cultured neurons .
8396705	0	diazepam_binding_inhibitor	50,76	DBI	78,81	diazepam binding inhibitor	DBI	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	ACTH-induced mitochondrial DBI receptor -LRB- MDR -RRB- and diazepam_binding_inhibitor -LRB- DBI -RRB- expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action .
8529966	0	diazepam_binding_inhibitor	28,54	DBI	56,59	diazepam binding inhibitor	DBI	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	-LSB- Functional significance of diazepam_binding_inhibitor -LRB- DBI -RRB- in establishment of alcohol_dependence -RSB- .
8750843	0	diazepam_binding_inhibitor	19,45	DBI	47,50	diazepam binding inhibitor	DBI	1622	1622	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Ethanol stimulates diazepam_binding_inhibitor -LRB- DBI -RRB- mRNA expression in primary cultured neurons .
9613098	0	diazepam_binding_inhibitor	27,53	DBI	55,58	diazepam binding inhibitor	DBI	13167(Tax:10090)	13167(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	-LSB- Functional involvement of diazepam_binding_inhibitor -LRB- DBI -RRB- in the establishment of drug_dependence -RSB- .
8972548	0	diazepam_binding_inhibitor	33,59	GABA-A	8,14	diazepam binding inhibitor	GABA-A	13167(Tax:10090)	14405(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Role of GABA-A and mitochondrial diazepam_binding_inhibitor receptors in the anti-stress activity of neurosteroids in mice .
17452327	0	dicer	73,78	TRBP	6,10	dicer	TRBP	23405	6896	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA .
8941343	0	differentiation-specific_element_binding_protein	30,78	DSEB	80,84	differentiation-specific element binding protein	DSEB	19687(Tax:10090)	19687(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Antisense oligonucleotides to differentiation-specific_element_binding_protein -LRB- DSEB -RRB- mRNA inhibit adipocyte differentiation .
8346219	0	differentiation_antigen_gp160	38,67	aminopeptidase_A	75,91	differentiation antigen gp160	aminopeptidase A	2028	2028	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Molecular cloning of the human kidney differentiation_antigen_gp160 : human aminopeptidase_A .
19338756	0	dihydrodipicolinate_synthase	42,70	DHDPS	72,77	dihydrodipicolinate synthase	DHDPS	8319276(Tax:562)	8319276(Tax:562)	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The C-terminal domain of Escherichia_coli dihydrodipicolinate_synthase -LRB- DHDPS -RRB- is essential for maintenance of quaternary structure and efficient catalysis .
14718498	0	dihydroflavonol-4-reductase	45,72	DFR	74,77	dihydroflavonol-4-reductase	DFR	543117(Tax:4565)	543117(Tax:4565)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Isolation and location of three homoeologous dihydroflavonol-4-reductase -LRB- DFR -RRB- genes of wheat and their tissue-dependent expression .
2827121	0	dihydrofolate_reductase	59,82	DFR1	89,93	dihydrofolate reductase	DFR1	854411(Tax:4932)	854411(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the Saccharomyces_cerevisiae dihydrofolate_reductase gene -LRB- DFR1 -RRB- .
2838386	0	dihydrofolate_reductase	30,53	DFR1	60,64	dihydrofolate reductase	DFR1	854411(Tax:4932)	854411(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping and sequencing of the dihydrofolate_reductase gene -LRB- DFR1 -RRB- of Saccharomyces_cerevisiae .
11877086	0	dihydrofolate_reductase	65,88	DHFR	95,99	dihydrofolate reductase	DHFR	1719	1719	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- In vitro cotransfer human multidrug resistance gene -LRB- mdr-1 -RRB- and dihydrofolate_reductase gene -LRB- DHFR -RRB- into human CD -LRB- 34 -RRB- -LRB- + -RRB- progenitor cells to broaden the spectrum of drug resistance -RSB- .
12653939	0	dihydrofolate_reductase	40,63	DHFR	65,69	dihydrofolate reductase	DHFR	42003(Tax:7227)	42003(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and expression of the dihydrofolate_reductase -LRB- DHFR -RRB- gene from adult buffalo fly -LRB- Haematobia irritans exigua -RRB- : effects of antifolates .
17336564	0	dihydrofolate_reductase	28,51	DHFR	53,57	dihydrofolate reductase	DHFR	1719	1719	Gene	Gene	Variation|nmod|START_ENTITY Variation|appos|END_ENTITY	Variation and expression of dihydrofolate_reductase -LRB- DHFR -RRB- in relation to spina_bifida .
18247058	0	dihydrofolate_reductase	42,65	DHFR	67,71	dihydrofolate reductase	DHFR	1719	1719	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An insertion/deletion polymorphism of the dihydrofolate_reductase -LRB- DHFR -RRB- gene is associated with serum and red blood cell folate concentrations in women .
21120433	0	dihydrofolate_reductase	42,65	DHFR	67,71	dihydrofolate reductase	DHFR	1719	1719	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	19-base pair deletion polymorphism of the dihydrofolate_reductase -LRB- DHFR -RRB- gene : maternal risk of Down syndrome and folate metabolism .
22324981	0	dihydrofolate_reductase	15,38	DHFR	40,44	dihydrofolate reductase	DHFR	1719	1719	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of dihydrofolate_reductase -LRB- DHFR -RRB- -317 AA genotype with poor response to methotrexate in patients with rheumatoid_arthritis .
8841631	0	dihydrofolate_reductase	88,111	DHFR	82,86	dihydrofolate reductase	DHFR	1719	1719	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel screening system for construction and selection of active ribozymes using DHFR -LRB- dihydrofolate_reductase -RRB- gene as selection marker .
18451149	0	dihydrofolate_reductase	15,38	MDM2	0,4	dihydrofolate reductase	MDM2	1719	4193	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	MDM2 regulates dihydrofolate_reductase activity through monoubiquitination .
9109647	0	dihydrofolate_reductase	99,122	NADPH	59,64	dihydrofolate reductase	NADPH	1719	1666	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate_reductase .
1597451	0	dihydrofolate_reductase	46,69	Sp1	27,30	dihydrofolate reductase	Sp1	1719	6667	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|nsubj|END_ENTITY	Triplex formation prevents Sp1 binding to the dihydrofolate_reductase promoter .
15205349	0	dihydrofolate_reductase	28,51	p14ARF	0,6	dihydrofolate reductase	p14ARF	1719	1029	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	p14ARF expression increases dihydrofolate_reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53 .
3339615	0	dihydrofolate_reductase	52,75	thymidylate_synthase	21,41	dihydrofolate reductase	thymidylate synthase	1719	22171(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of murine thymidylate_synthase and human dihydrofolate_reductase by 5,8-dideaza analogues of folic_acid and aminopterin .
17404228	0	dihydrolipoamide_dehydrogenase	32,62	Cryptic	0,7	dihydrolipoamide dehydrogenase	Cryptic	1738	55997	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Cryptic proteolytic activity of dihydrolipoamide_dehydrogenase .
10051437	0	dihydrolipoamide_dehydrogenase	86,116	Dld	118,121	dihydrolipoamide dehydrogenase	Dld	13382(Tax:10090)	13382(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide_dehydrogenase -LRB- Dld -RRB- gene .
9169128	0	dihydrolipoamide_dehydrogenase	30,60	Dld	62,65	dihydrolipoamide dehydrogenase	Dld	13382(Tax:10090)	13382(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the mouse dihydrolipoamide_dehydrogenase -LRB- Dld -RRB- gene : genomic structure , promoter sequence , and chromosomal localization .
8584231	0	dihydrolipoyl_succinyltransferase	44,77	DLST	79,83	dihydrolipoyl succinyltransferase	DLST	1743	1743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the chromosome 14q24 .3 dihydrolipoyl_succinyltransferase -LRB- DLST -RRB- gene in patients with early-onset Alzheimer_disease .
22242798	0	dihydroorotate_dehydrogenase	70,98	DHODH	100,105	dihydroorotate dehydrogenase	DHODH	1723	1723	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	CoMFA and CoMSIA studies on aryl_carboxylic_acid_amide derivatives as dihydroorotate_dehydrogenase -LRB- DHODH -RRB- inhibitors .
18834876	0	dihydroorotate_dehydrogenase	52,80	S-2678	92,98	dihydroorotate dehydrogenase	S-2678	56749(Tax:10090)	1078950(Tax:198215)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Suppression of immunoglobulin production by a novel dihydroorotate_dehydrogenase inhibitor , S-2678 .
16550931	0	dihydropyridine_receptor	69,93	dysferlin	30,39	dihydropyridine receptor	dysferlin	779	8291	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Intracellular localization of dysferlin and its association with the dihydropyridine_receptor .
16321170	0	dihydropyrimidinase-like_2	24,50	DPYSL2	52,58	dihydropyrimidinase-like 2	DPYSL2	1808	1808	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An investigation of the dihydropyrimidinase-like_2 -LRB- DPYSL2 -RRB- gene in schizophrenia : genetic association study and expression analysis .
10574455	0	dihydropyrimidinase-related_protein_2	30,67	DRP-2	69,74	dihydropyrimidinase-related protein 2	DRP-2	1821	1821	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the human dihydropyrimidinase-related_protein_2 -LRB- DRP-2 -RRB- gene .
12951196	0	dihydropyrimidinase-related_protein_2	27,64	DRP-2	66,71	dihydropyrimidinase-related protein 2	DRP-2	1821	1821	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between the dihydropyrimidinase-related_protein_2 -LRB- DRP-2 -RRB- gene and bipolar_disorder in humans .
15027329	0	dihydropyrimidinase-related_protein_2	11,48	DRP-2	50,55	dihydropyrimidinase-related protein 2	DRP-2	1821	1821	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The human dihydropyrimidinase-related_protein_2 -LRB- DRP-2 -RRB- gene on chromosome 8p21 is associated with paranoid-type_schizophrenia -RSB- .
17196711	0	dihydropyrimidinase-related_protein_2	16,53	spectrin_alpha_II_chain	55,78	dihydropyrimidinase-related protein 2	spectrin alpha II chain	66027(Tax:10116)	64159(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Upregulation of dihydropyrimidinase-related_protein_2 , spectrin_alpha_II_chain , heat_shock cognate protein 70 pseudogene 1 and tropomodulin_2 after focal cerebral_ischemia in rats -- a proteomics approach .
9712324	0	dihydropyrimidinase-related_protein_3	37,74	DRP-3	76,81	dihydropyrimidinase-related protein 3	DRP-3	22240(Tax:10090)	22240(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Post-meiotic expression of the mouse dihydropyrimidinase-related_protein_3 -LRB- DRP-3 -RRB- gene during spermiogenesis .
10925685	0	dihydropyrimidine_dehydrogenase	47,78	DPD	80,83	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Significance of thymidylate_synthase -LRB- TS -RRB- and dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in breast_cancer tissue -RSB- .
11290431	0	dihydropyrimidine_dehydrogenase	20,51	DPD	53,56	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The significance of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in bladder_cancer .
11555601	0	dihydropyrimidine_dehydrogenase	45,76	DPD	78,81	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prevalence of a common point mutation in the dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- gene within the 5 ' - splice donor site of intron 14 in patients with severe 5-fluorouracil -LRB- 5-FU -RRB- - related toxicity compared with controls .
12617910	0	dihydropyrimidine_dehydrogenase	55,86	DPD	88,91	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Design and synthesis of the tumor-activated prodrug of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- inhibitor , RO0094889 for combination therapy with capecitabine .
12851836	0	dihydropyrimidine_dehydrogenase	25,56	DPD	58,61	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Clinical implications of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in 5-FU-based chemotherapy : mutations in the DPD gene , and DPD inhibitory fluoropyrimidines .
12852985	0	dihydropyrimidine_dehydrogenase	25,56	DPD	58,61	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Circadian variations of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in oral mucosa of healthy volunteers -RSB- .
15271097	0	dihydropyrimidine_dehydrogenase	164,195	DPD	197,200	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	A simple and rapid high-performance liquid chromatographic -LRB- HPLC -RRB- method for 5-fluorouracil -LRB- 5-FU -RRB- assay in plasma and possible detection of patients with impaired dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity .
15566669	0	dihydropyrimidine_dehydrogenase	22,53	DPD	54,57	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Relationship between dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity and toxicity of 5-FU-based adjuvant chemotherapy in colorectal_cancer patients -RSB- .
15604991	0	dihydropyrimidine_dehydrogenase	76,107	DPD	109,112	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Evaluation of sensitivity to 5-FU on the basis of thymidylate_synthase -LRB- TS -RRB- / dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity and chromosomal analysis in micro tissue specimens of breast_cancer .
15616154	0	dihydropyrimidine_dehydrogenase	92,123	DPD	125,128	dihydropyrimidine dehydrogenase	DPD	479935(Tax:9615)	479935(Tax:9615)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Relationships among plasma -LSB- 2 - -LRB- 13 -RRB- C -RSB- uracil concentrations , breath -LRB- 13 -RRB- CO -LRB- 2 -RRB- expiration , and dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity in the liver in normal and dpd-deficient dogs .
19628084	0	dihydropyrimidine_dehydrogenase	34,65	DPD	67,70	dihydropyrimidine dehydrogenase	DPD	81656(Tax:10116)	81656(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Circadian variation in intestinal dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- expression : a potential mechanism for benefits of 5FU chrono-chemotherapy .
21353513	0	dihydropyrimidine_dehydrogenase	78,109	DPD	111,114	dihydropyrimidine dehydrogenase	DPD	99586(Tax:10090)	99586(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- protein expression .
9323539	0	dihydropyrimidine_dehydrogenase	47,78	DPD	80,83	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Semi-automated radioassay for determination of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- activity .
9830621	0	dihydropyrimidine_dehydrogenase	12,43	DPD	45,48	dihydropyrimidine dehydrogenase	DPD	1806	1806	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of dihydropyrimidine_dehydrogenase -LRB- DPD -RRB- modulation in 5-FU pharmacology .
19288105	0	dihydropyrimidine_dehydrogenase	43,74	DPYD	76,80	dihydropyrimidine dehydrogenase	DPYD	1806	1806	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of large intragenic rearrangements in dihydropyrimidine_dehydrogenase -LRB- DPYD -RRB- gene in fluoropyrimidine-treated patients with high-grade toxicity .
25117664	0	dihydropyrimidine_dehydrogenase	21,52	DPYD	54,58	dihydropyrimidine dehydrogenase	DPYD	1806	1806	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in dihydropyrimidine_dehydrogenase -LRB- DPYD -RRB- gene in a healthy adult Indian population .
19020767	0	dihydropyrimidine_dehydrogenase	22,53	orotate_phosphoribosyltransferase	55,88	dihydropyrimidine dehydrogenase	orotate phosphoribosyltransferase	1806	7372	Gene	Gene	synthase|appos|START_ENTITY END_ENTITY|nsubj|synthase	Thymidylate synthase , dihydropyrimidine_dehydrogenase , orotate_phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis .
21791367	0	dihydropyrimidine_dehydrogenase	22,53	orotate_phosphoribosyltransferase	80,113	dihydropyrimidine dehydrogenase	orotate phosphoribosyltransferase	1806	7372	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
18630517	0	dihydropyrimidine_dehydrogenase	77,108	thymidine_phosphorylase	30,53	dihydropyrimidine dehydrogenase	thymidine phosphorylase	1806	1890	Gene	Gene	thymidylate_synthase|dep|START_ENTITY thymidylate_synthase|nsubj|Changes Changes|nmod|expression expression|nmod|END_ENTITY	Changes of gene expression of thymidine_phosphorylase , thymidylate_synthase , dihydropyrimidine_dehydrogenase after the administration of 5 ' - deoxy-5-fluorouridine , paclitaxel and its combination in human gastric_cancer xenografts .
21791367	0	dihydropyrimidine_dehydrogenase	22,53	thymidine_phosphorylase	55,78	dihydropyrimidine dehydrogenase	thymidine phosphorylase	1806	1890	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
22935001	0	dilp6	35,40	Drosophila_insulin-like_peptide-6	0,33	dilp6	Drosophila insulin-like peptide-6	31220(Tax:7227)	31220(Tax:7227)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Drosophila_insulin-like_peptide-6 -LRB- dilp6 -RRB- expression from fat body extends lifespan and represses secretion of Drosophila_insulin-like_peptide-2 from the brain .
8689583	0	dilute-opisthotonus	15,34	dop	36,39	dilute-opisthotonus	dop	25017(Tax:10116)	25017(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the dilute-opisthotonus -LRB- dop -RRB- gene on chromosome 8 of the rat .
10873650	0	dim1p	91,96	Npw38	7,12	dim1p	Npw38	10907	10084	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PQBP-1 / Npw38 , a nuclear protein binding to the polyglutamine tract , interacts with U5-15kD / dim1p via the carboxyl-terminal domain .
23770786	0	dimethylarginine-dimethylaminohydrolase-II	16,58	DDAH2	60,65	dimethylarginine-dimethylaminohydrolase-II	DDAH2	23564	23564	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Distribution of dimethylarginine-dimethylaminohydrolase-II -LRB- DDAH2 -RRB- gene polymorphism in hemodialysis patients .
17296339	0	dimethylarginine_dimethylaminohydrolase	58,97	DDAH	99,103	dimethylarginine dimethylaminohydrolase	DDAH	51793(Tax:10090)	51793(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	A stable-isotope based technique for the determination of dimethylarginine_dimethylaminohydrolase -LRB- DDAH -RRB- activity in mouse tissue .
23097221	0	dimethylarginine_dimethylaminohydrolase	12,51	DDAH	53,57	dimethylarginine dimethylaminohydrolase	DDAH	23576	23576	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of dimethylarginine_dimethylaminohydrolase -LRB- DDAH -RRB- in pulmonary_fibrosis .
23892448	0	dimethylarginine_dimethylaminohydrolase_1	25,66	DDAH1	73,78	dimethylarginine dimethylaminohydrolase 1	DDAH1	23576	23576	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the dimethylarginine_dimethylaminohydrolase_1 gene -LRB- DDAH1 -RRB- is related to asymmetric dimethylarginine -LRB- ADMA -RRB- levels , but not to endothelium-dependent vasodilation .
17977009	0	dimethylarginine_dimethylaminohydrolase_2	81,122	DDAH2	124,129	dimethylarginine dimethylaminohydrolase 2	DDAH2	23564	23564	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nebivolol reduces asymmetric_dimethylarginine in endothelial cells by increasing dimethylarginine_dimethylaminohydrolase_2 -LRB- DDAH2 -RRB- expression and activity .
9760177	0	dipeptidyl-peptidase_IV	73,96	CD26	109,113	dipeptidyl-peptidase IV	CD26	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Dipeptidyl-peptidase_IV-beta -- further characterization and comparison to dipeptidyl-peptidase_IV activity of CD26 .
11737260	0	dipeptidyl-peptidase_IV	14,37	CD8	48,51	dipeptidyl-peptidase IV	CD8	1803	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of dipeptidyl-peptidase_IV -LRB- CD26 -RRB- on CD8 + T cells is significantly decreased in patients with psoriasis_vulgaris and atopic_dermatitis .
21595280	0	dipeptidyl_peptidase-4	49,71	DPP-4	73,78	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Severe hypoglycemia by combination therapy with dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors and sulfonylureas -RSB- .
21613229	0	dipeptidyl_peptidase-4	22,44	DPP-4	46,51	dipeptidyl peptidase-4	DPP-4	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Protective effects of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor against increased b cell apoptosis induced by dietary sucrose and linoleic_acid in mice with diabetes .
22162539	0	dipeptidyl_peptidase-4	47,69	DPP-4	71,76	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Quantitative model of the relationship between dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibition and response : meta-analysis of alogliptin , saxagliptin , sitagliptin , and vildagliptin efficacy results .
24531198	0	dipeptidyl_peptidase-4	70,92	DPP-4	94,99	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors .
24614606	0	dipeptidyl_peptidase-4	29,51	DPP-4	53,58	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Comparative effectiveness of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors and human glucagon-like_peptide-1 -LRB- GLP-1 -RRB- analogue as add-on therapies to sulphonylurea among diabetes patients in the Asia-Pacific region : a systematic review .
24622716	0	dipeptidyl_peptidase-4	29,51	DPP-4	53,58	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	SYR-472 , a novel once-weekly dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor , in type_2_diabetes_mellitus : a phase 2 , randomised , double-blind , placebo-controlled trial .
24829965	0	dipeptidyl_peptidase-4	14,36	DPP-4	38,43	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	The safety of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors or sodium-glucose_cotransporter_2 -LRB- SGLT-2 -RRB- inhibitors added to metformin background therapy in patients with type_2_diabetes_mellitus : a systematic review and meta-analysis .
24993124	0	dipeptidyl_peptidase-4	30,52	DPP-4	54,59	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Alogliptin ; a review of a new dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitor for the treatment of type_2_diabetes_mellitus .
25169215	0	dipeptidyl_peptidase-4	94,116	DPP-4	118,123	dipeptidyl peptidase-4	DPP-4	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Plants Fagonia cretica L. and Hedera_nepalensis K. Koch contain natural compounds with potent dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitory activity .
27040669	0	dipeptidyl_peptidase-4	11,33	DPP-4	35,40	dipeptidyl peptidase-4	DPP-4	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Effects of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibition on angiogenesis and hypoxic_injury_in_type_2_diabetes .
26873580	0	dipeptidyl_peptidase-4	96,118	DPP4	120,124	dipeptidyl peptidase-4	DPP4	1803	1803	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A concise review of the bioanalytical methods for the quantitation of sitagliptin , an important dipeptidyl_peptidase-4 -LRB- DPP4 -RRB- inhibitor , utilized for the pharmacokinetic characterization of the drug .
17244767	0	dipeptidyl_peptidase-4	101,123	MK-0431	89,96	dipeptidyl peptidase-4	MK-0431	1803	1477734(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY pharmacokinetics|appos|inhibitor pharmacokinetics|appos|END_ENTITY	Effect of a single cyclosporine dose on the single-dose pharmacokinetics of sitagliptin -LRB- MK-0431 -RRB- , a dipeptidyl_peptidase-4 inhibitor , in healthy male subjects .
24059225	0	dipeptidyl_peptidase-4	11,33	MK-0626	0,7	dipeptidyl peptidase-4	MK-0626	13482(Tax:10090)	1476727(Tax:190192)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	MK-0626 , a dipeptidyl_peptidase-4 inhibitor , improves neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric_oxide synthetase expression .
21755761	0	dipeptidyl_peptidase-IV	17,40	DPP-4	42,47	dipeptidyl peptidase-IV	DPP-4	1803	1803	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Emerging role of dipeptidyl_peptidase-IV -LRB- DPP-4 -RRB- inhibitor vildagliptin in the management of type 2 diabetes .
16106524	0	dipeptidyl_peptidase-IV	107,130	DPP-IV	132,138	dipeptidyl peptidase-IV	DPP-IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	KR-62436 , 6 - -LCB- 2 - -LSB- 2 - -LRB- 5-cyano-4 ,5 - dihydropyrazol-1-yl -RRB- -2 - oxoethylamino -RSB- ethylamino -RCB- nicotinonitrile , is a novel dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor with anti-hyperglycemic activity .
18068977	0	dipeptidyl_peptidase-IV	14,37	DPP-IV	39,45	dipeptidyl peptidase-IV	DPP-IV	1803	1803	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- by atorvastatin .
20082866	0	dipeptidyl_peptidase-IV	10,33	DPP-IV	35,41	dipeptidyl peptidase-IV	DPP-IV	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effect of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- inhibitor -LRB- Vildagliptin -RRB- on peripheral nerves in streptozotocin-induced diabetic rats .
20213998	0	dipeptidyl_peptidase-IV	27,50	DPP-IV	52,58	dipeptidyl peptidase-IV	DPP-IV	1803	1803	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- in Indian type-2 diabetic population .
26592960	0	dipeptidyl_peptidase-IV	14,37	DPP-IV	39,45	dipeptidyl peptidase-IV	DPP-IV	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Monitoring of dipeptidyl_peptidase-IV -LRB- DPP-IV -RRB- activity in patients with mucopolysaccharidoses types I and II on enzyme replacement therapy - Results of a pilot study .
21656024	0	dipeptidyl_peptidase-IV	50,73	High_mobility_group_box_1	0,25	dipeptidyl peptidase-IV	High mobility group box 1	1803	3146	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	High_mobility_group_box_1 is a novel substrate of dipeptidyl_peptidase-IV .
21088147	0	dipeptidyl_peptidase_1	73,95	DPP1	97,101	dipeptidyl peptidase 1	DPP1	1075	1075	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Development and validation of a simple cell-based fluorescence assay for dipeptidyl_peptidase_1 -LRB- DPP1 -RRB- activity .
18582861	0	dipeptidyl_peptidase_4	30,52	ASP4	0,4	dipeptidyl peptidase 4	ASP4	1803	9476	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	ASP4 ,000 , a novel , selective , dipeptidyl_peptidase_4 inhibitor with antihyperglycemic activity .
18805447	0	dipeptidyl_peptidase_4	77,99	DP4	101,104	dipeptidyl peptidase 4	DP4	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The anti-inflammatory effect of neuropeptide_Y -LRB- NPY -RRB- in rats is dependent on dipeptidyl_peptidase_4 -LRB- DP4 -RRB- activity and age .
26048211	0	dipeptidyl_peptidase_4	64,86	DPP-4	88,93	dipeptidyl peptidase 4	DPP-4	1803	1803	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Hospitalisation for heart_failure and mortality associated with dipeptidyl_peptidase_4 -LRB- DPP-4 -RRB- inhibitor use in an unselected population of subjects with type 2 diabetes : a nested case-control study .
26611248	0	dipeptidyl_peptidase_4	65,87	DPP-4	89,94	dipeptidyl peptidase 4	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Lessons learned from cardiovascular outcome clinical trials with dipeptidyl_peptidase_4 -LRB- DPP-4 -RRB- inhibitors .
26671446	0	dipeptidyl_peptidase_4	39,61	DPP4	63,67	dipeptidyl peptidase 4	DPP4	1803	1803	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Unravelling the immunological roles of dipeptidyl_peptidase_4 -LRB- DPP4 -RRB- activity and/or structure homolog -LRB- DASH -RRB- proteins .
26983599	0	dipeptidyl_peptidase_4	18,40	DPP4	42,46	dipeptidyl peptidase 4	DPP4	1803	1803	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Metabolic role of dipeptidyl_peptidase_4 -LRB- DPP4 -RRB- in primary human -LRB- pre -RRB- adipocytes .
16110352	0	dipeptidyl_peptidase_8	22,44	DPP8	46,50	dipeptidyl peptidase 8	DPP8	54878	54878	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Expression of a novel dipeptidyl_peptidase_8 -LRB- DPP8 -RRB- transcript variant , DPP8-v3 , in human testis .
15585850	0	dipeptidyl_peptidase_I	106,128	cathepsin_C	94,105	dipeptidyl peptidase I	cathepsin C	1075	1075	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Papillon-Lef __ vre_syndrome : correlating the molecular , cellular , and clinical consequences of cathepsin_C / dipeptidyl_peptidase_I deficiency in humans .
3890514	0	dipeptidyl_peptidase_II	16,39	Dpp_II	41,47	dipeptidyl peptidase II	Dpp II	83799(Tax:10116)	83799(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of dipeptidyl_peptidase_II -LRB- Dpp_II -RRB- in rat spinal cord .
3924993	0	dipeptidyl_peptidase_II	93,116	serine_protease	68,83	dipeptidyl peptidase II	serine protease	83799(Tax:10116)	292866(Tax:10116)	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Cytochemical localization and biochemical evaluation of a lysosomal serine_protease in lung : dipeptidyl_peptidase_II in the normal rat .
10849736	0	dipeptidyl_peptidase_IV	67,90	CD26	98,102	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	A new type of fluorogenic substrates for determination of cellular dipeptidyl_peptidase_IV -LRB- DP_IV / CD26 -RRB- activity .
10998079	0	dipeptidyl_peptidase_IV	15,38	CD26	40,44	dipeptidyl peptidase IV	CD26	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Elevated serum dipeptidyl_peptidase_IV -LRB- CD26 , EC 3.4.14.5 -RRB- activity in experimental liver_cirrhosis .
12182835	0	dipeptidyl_peptidase_IV	56,79	CD26	80,84	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression , purification , and characterization of human dipeptidyl_peptidase_IV / CD26 in Sf9 insect cells .
12752434	0	dipeptidyl_peptidase_IV	19,42	CD26	44,48	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Different modes of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites .
1358482	0	dipeptidyl_peptidase_IV	20,43	CD26	45,49	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- from human lymphocytes .
1371820	0	dipeptidyl_peptidase_IV	38,61	CD26	32,36	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization of CD26 -LRB- dipeptidyl_peptidase_IV -RRB- : functional comparison of distinct epitopes recognized by various anti-CD26 monoclonal antibodies .
1374571	0	dipeptidyl_peptidase_IV	20,43	CD26	14,18	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD26 -LRB- dipeptidyl_peptidase_IV -RRB- on memory and naive T lymphocytes .
17592366	0	dipeptidyl_peptidase_IV	21,44	CD26	53,57	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Serum and intestinal dipeptidyl_peptidase_IV -LRB- DPP_IV / CD26 -RRB- activity in children with celiac_disease .
18508427	0	dipeptidyl_peptidase_IV	35,58	CD26	59,63	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	activity|nummod|START_ENTITY activity|compound|END_ENTITY	Non-substrate peptides influencing dipeptidyl_peptidase_IV / CD26 activity and immune cell function .
7833626	0	dipeptidyl_peptidase_IV	34,57	CD26	59,63	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Expression and functional role of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- on human natural killer cells .
7909722	0	dipeptidyl_peptidase_IV	12,35	CD26	37,41	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Function of dipeptidyl_peptidase_IV -LRB- CD26 , Tp103 -RRB- in transfected human T cells .
7927537	0	dipeptidyl_peptidase_IV	83,106	CD26	77,81	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic organization , exact localization , and tissue expression of the human CD26 -LRB- dipeptidyl_peptidase_IV -RRB- gene .
9204385	0	dipeptidyl_peptidase_IV	14,37	CD26	39,43	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- by peptide boronic_acid_dipeptides .
9605992	0	dipeptidyl_peptidase_IV	39,62	CD26	64,68	dipeptidyl peptidase IV	CD26	1803	1803	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Multicolor cytoenzymatic evaluation of dipeptidyl_peptidase_IV -LRB- CD26 -RRB- function in normal and neoplastic human T-lymphocyte populations .
17827003	0	dipeptidyl_peptidase_IV	116,139	DPP-4	141,146	dipeptidyl peptidase IV	DPP-4	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Design , synthesis , and biological evaluation of triazolopiperazine-based beta-amino_amides as potent , orally active dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitors .
21218817	0	dipeptidyl_peptidase_IV	98,121	DPP-4	123,128	dipeptidyl peptidase IV	DPP-4	1803	1803	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Discovery of a 3-pyridylacetic_acid derivative -LRB- TAK-100 -RRB- as a potent , selective and orally active dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitor .
22938786	0	dipeptidyl_peptidase_IV	74,97	DPP-4	99,104	dipeptidyl peptidase IV	DPP-4	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of 3H-imidazo -LSB- 4,5-c -RSB- quinolin-4 -LRB- 5H -RRB- - ones as potent and selective dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitors .
25596166	0	dipeptidyl_peptidase_IV	74,97	DPP-4	99,104	dipeptidyl peptidase IV	DPP-4	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of 3H-imidazo -LSB- 4,5-c -RSB- quinolin-4 -LRB- 5H -RRB- - ones as potent and selective dipeptidyl_peptidase_IV -LRB- DPP-4 -RRB- inhibitors : Use of a carboxylate prodrug to improve bioavailability .
15002062	0	dipeptidyl_peptidase_IV	53,76	DPP-IV	78,84	glucagon-like Peptide 1	DPP-IV	2641	1803	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Glucagon-like_peptide_1 -LRB- GLP-1 -RRB- secretion and plasma dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- activity in morbidly obese patients undergoing biliopancreatic diversion .
19162567	0	dipeptidyl_peptidase_IV	162,185	DPP-IV	187,193	dipeptidyl peptidase IV	DPP-IV	1803	1803	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Remediation of undesirable secondary interactions encountered in hydrophilic interaction chromatography during development of a quantitative LC-MS/MS assay for a dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitor in monkey serum .
24193022	0	dipeptidyl_peptidase_IV	14,37	DPP-IV	39,45	dipeptidyl peptidase IV	DPP-IV	1803	1803	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- by tryptophan containing dipeptides .
24793774	0	dipeptidyl_peptidase_IV	82,105	DPP-IV	107,113	dipeptidyl peptidase IV	DPP-IV	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	In silico approaches to predict the potential of milk protein-derived peptides as dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitors .
25838146	0	dipeptidyl_peptidase_IV	169,192	DPP-IV	194,200	dipeptidyl peptidase IV	DPP-IV	1803	1803	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and potent inhibitory activities of carboxybenzyl-substituted_8 - -LRB- 3 - -LRB- R -RRB- - aminopiperidin-1-yl -RRB- -7 - -LRB- 2-chloro/cyanobenzyl -RRB- -3 - methyl-3 ,7 - dihydro-purine-2 ,6 - diones as dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitors .
17276063	0	dipeptidyl_peptidase_IV	108,131	DPP4	133,137	dipeptidyl peptidase IV	DPP4	25253(Tax:10116)	25253(Tax:10116)	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Pyrrolidine-constrained phenethylamines : The design of potent , selective , and pharmacologically efficacious dipeptidyl_peptidase_IV -LRB- DPP4 -RRB- inhibitors from a lead-like screening hit .
17204353	0	dipeptidyl_peptidase_IV	18,41	DPPIV	43,48	dipeptidyl peptidase IV	DPPIV	1803	1803	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Serum activity of dipeptidyl_peptidase_IV -LRB- DPPIV ; EC 3.4.14.5 -RRB- in breast-fed infants with symptoms of allergy .
10103156	0	dipeptidyl_peptidase_IV	16,39	DPP_IV	41,47	dipeptidyl peptidase IV	DPP IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Development of dipeptidyl_peptidase_IV -LRB- DPP_IV -RRB- activity in postnatal differentiation of the submandibular gland in mice -RSB- .
19640223	0	dipeptidyl_peptidase_IV	14,37	DPP_IV	39,45	dipeptidyl peptidase IV	DPP IV	1803	1803	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DPP_IV -RRB- is one of the mechanisms explaining the hypoglycemic effect of berberine .
10849736	0	dipeptidyl_peptidase_IV	67,90	DP_IV	92,97	dipeptidyl peptidase IV	DP IV	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	A new type of fluorogenic substrates for determination of cellular dipeptidyl_peptidase_IV -LRB- DP_IV / CD26 -RRB- activity .
11309152	0	dipeptidyl_peptidase_IV	14,37	DP_IV	39,44	dipeptidyl peptidase IV	DP IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV -LRB- DP_IV , CD26 -RRB- activity abrogates stress-induced , cytokine-mediated murine abortions .
2871821	0	dipeptidyl_peptidase_IV	32,55	DP_IV	57,62	dipeptidyl peptidase IV	DP IV	1803	1803	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	-LSB- Diagnostic value of the enzyme dipeptidyl_peptidase_IV -LRB- DP_IV -RRB- in abdominal_cancers -RSB- .
9436466	0	dipeptidyl_peptidase_IV	14,37	DP_IV	39,44	dipeptidyl peptidase IV	DP IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|appos|END_ENTITY	Inhibitors of dipeptidyl_peptidase_IV -LRB- DP_IV , CD26 -RRB- induces secretion of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- in stimulated mouse splenocytes and thymocytes .
16475979	0	dipeptidyl_peptidase_IV	88,111	Dipeptidyl_peptidases_8_and_9	0,29	dipeptidyl peptidase IV	Dipeptidyl peptidases 8 and 9	1803	54878;91039	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|dep|characterization	Dipeptidyl_peptidases_8_and_9 : specificity and molecular characterization compared with dipeptidyl_peptidase_IV .
18299314	0	dipeptidyl_peptidase_IV	14,37	MK0431	56,62	dipeptidyl peptidase IV	MK0431	13482(Tax:10090)	1477734(Tax:190192)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of dipeptidyl_peptidase_IV with sitagliptin -LRB- MK0431 -RRB- prolongs islet graft survival in streptozotocin-induced diabetic mice .
20368408	0	dipeptidyl_peptidase_IV	35,58	MK0431	13,19	dipeptidyl peptidase IV	MK0431	13482(Tax:10090)	1477734(Tax:190192)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Sitagliptin -LRB- MK0431 -RRB- inhibition of dipeptidyl_peptidase_IV decreases nonobese diabetic mouse CD4 + T-cell migration through incretin-dependent and - independent pathways .
1975616	0	dipeptidyl_peptidase_IV	60,83	Ta1	53,56	dipeptidyl peptidase IV	Ta1	1803	134864	Gene	Gene	monoclonal|nmod|START_ENTITY monoclonal|dobj|END_ENTITY	Binding of the T cell activation monoclonal antibody Ta1 to dipeptidyl_peptidase_IV .
10583373	0	dipeptidyl_peptidase_IV	17,40	adenosine_deaminase	44,63	dipeptidyl peptidase IV	adenosine deaminase	1803	100	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding to human dipeptidyl_peptidase_IV by adenosine_deaminase and antibodies that inhibit ligand binding involves overlapping , discontinuous sites on a predicted beta propeller domain .
12009420	0	dipeptidyl_peptidase_IV	26,49	adenosine_deaminase	55,74	dipeptidyl peptidase IV	adenosine deaminase	1803	100	Gene	Gene	role|nmod|START_ENTITY adenosine_deaminase|nmod|role adenosine_deaminase|parataxis|= =|ccomp|protein protein|amod|END_ENTITY	On the regulatory role of dipeptidyl_peptidase_IV -LRB- = CD = adenosine_deaminase complexing protein -RRB- on adenosine_deaminase activity .
12009420	0	dipeptidyl_peptidase_IV	26,49	adenosine_deaminase	98,117	dipeptidyl peptidase IV	adenosine deaminase	1803	100	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nmod|role	On the regulatory role of dipeptidyl_peptidase_IV -LRB- = CD = adenosine_deaminase complexing protein -RRB- on adenosine_deaminase activity .
16929383	0	dipeptidyl_peptidase_IV	13,36	adenosine_deaminase	64,83	dipeptidyl peptidase IV	adenosine deaminase	281122(Tax:9913)	280712(Tax:9913)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of dipeptidyl_peptidase_IV on enzymatic properties of adenosine_deaminase .
7628397	0	dipeptidyl_peptidase_IV	122,145	glucagon-like_peptide_1	74,97	dipeptidyl peptidase IV	glucagon-like peptide 1	25253(Tax:10116)	24952(Tax:10116)	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of glucose-dependent_insulinotropic_polypeptide and truncated glucagon-like_peptide_1 in vitro and in vivo by dipeptidyl_peptidase_IV .
26988873	0	dipeptidyl_peptidase_IV	80,103	milk	45,49	dipeptidyl peptidase IV	milk	1803	100532204	Gene	Gene	peptides|nmod|START_ENTITY peptides|compound|END_ENTITY	Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitory activity .
2430307	0	dipeptidyl_peptidase_IV	63,86	substance_P	109,120	dipeptidyl peptidase IV	substance P	1803	6863	Gene	Gene	hydrolysis|amod|START_ENTITY hydrolysis|nmod|END_ENTITY	Contamination of highly purified human serum cholinesterase by dipeptidyl_peptidase_IV causing hydrolysis of substance_P .
19538242	0	dipeptidylpeptidase-4	49,70	DPP-4	72,77	dipeptidylpeptidase-4	DPP-4	1803	1803	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Investigation of the effect of oral metformin on dipeptidylpeptidase-4 -LRB- DPP-4 -RRB- activity in Type 2 diabetes .
7903569	0	dipeptidylpeptidase_IV	18,40	DPP4	42,46	dipeptidylpeptidase IV	DPP4	397492(Tax:9823)	397492(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the dipeptidylpeptidase_IV -LRB- DPP4 -RRB- gene to pig chromosome 15q21 .
12657250	0	dipeptidylpeptidase_IV	95,117	DPP_IV	119,125	dipeptidylpeptidase IV	DPP IV	13482(Tax:10090)	13482(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	The expression of T-cell surface antigens CTLA-4 , CD26 , and CD28 is modulated by inhibition of dipeptidylpeptidase_IV -LRB- DPP_IV , CD26 -RRB- activity in murine stress-induced abortions .
7904591	0	dipeptidylpeptidase_IV	25,47	Interferon-gamma	0,16	dipeptidylpeptidase IV	Interferon-gamma	1803	3458	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interferon-gamma induces dipeptidylpeptidase_IV expression in human glomerular epithelial cells .
8668124	0	diphenol_oxidase_A2	119,138	Dox-A2	145,151	diphenol oxidase A2	Dox-A2	35176(Tax:7227)	35176(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A multicopy suppressor of nin1-1 of the yeast Saccharomyces_cerevisiae is a counterpart of the Drosophila_melanogaster diphenol_oxidase_A2 gene , Dox-A2 .
9782084	0	diphthamide_biosynthesis-like_protein-2	36,75	DPH2L2	82,88	diphthamide biosynthesis-like protein-2	DPH2L2	1802	1802	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and localization of a human diphthamide_biosynthesis-like_protein-2 gene , DPH2L2 .
10571241	0	disabled-1	98,108	Reelin	18,24	disabled-1	Reelin	13131(Tax:10090)	19699(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|phosphorylation induces|dobj|phosphorylation induces|nsubj|binding binding|nmod|END_ENTITY	Direct binding of Reelin to VLDL_receptor and ApoE_receptor_2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation .
12446734	0	disabled-1	18,28	Reelin	70,76	disabled-1	Reelin	1600	5649	Gene	Gene	START_ENTITY|appos|adaptor adaptor|nmod|pathway pathway|compound|END_ENTITY	The gene encoding disabled-1 -LRB- DAB1 -RRB- , the intracellular adaptor of the Reelin pathway , reveals unusual complexity in human and mouse .
19074029	0	disabled-1	64,74	Reelin	82,88	disabled-1	Reelin	13131(Tax:10090)	19699(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway .
15175076	0	disabled-1	30,40	reelin	4,10	disabled-1	reelin	1600	5649	Gene	Gene	components|amod|START_ENTITY components|amod|END_ENTITY	The reelin pathway components disabled-1 and p35 in gangliogliomas -- a mutation and expression analysis .
25139876	0	disco-interacting_protein_2_homolog_A	44,81	Akt	82,85	disco-interacting protein 2 homolog A	Akt	690211(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Follistatin-like_1 attenuates apoptosis via disco-interacting_protein_2_homolog_A / Akt pathway after middle_cerebral_artery_occlusion in rats .
18664364	0	discoidin_domain_receptor-2	16,43	p38	63,66	discoidin domain receptor-2	p38	4921	1432	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Hypoxia induces discoidin_domain_receptor-2 expression via the p38 pathway in vascular smooth muscle cells to increase their migration .
25774665	0	discoidin_domain_receptor_1	53,80	membrane-type-1_matrix_metalloproteinase	2,42	discoidin domain receptor 1	membrane-type-1 matrix metalloproteinase	780	4323	Gene	Gene	axis|amod|START_ENTITY END_ENTITY|dep|axis	A membrane-type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- - discoidin_domain_receptor_1 axis regulates collagen-induced apoptosis in breast_cancer cells .
20734453	0	discoidin_domain_receptor_2	21,48	DDR2	50,54	discoidin domain receptor 2	DDR2	4921	4921	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	An essential role of discoidin_domain_receptor_2 -LRB- DDR2 -RRB- in osteoblast differentiation and chondrocyte maturation via modulation of Runx2 activation .
24885564	0	discoidin_domain_receptor_2	48,75	DDR2	77,81	discoidin domain receptor 2	DDR2	4921	4921	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of novel driver mutations of the discoidin_domain_receptor_2 -LRB- DDR2 -RRB- gene in squamous_cell_lung_cancer of Chinese patients .
25355563	0	discoidin_domain_receptor_2	28,55	DDR2	57,61	discoidin domain receptor 2	DDR2	4921	4921	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The anti-angiogenic role of discoidin_domain_receptor_2 -LRB- DDR2 -RRB- in laser-induced choroidal_neovascularization .
23644467	0	discoidin_domain_receptor_2	22,49	SNAIL1	61,67	discoidin domain receptor 2	SNAIL1	4921	6615	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	The collagen receptor discoidin_domain_receptor_2 stabilizes SNAIL1 to facilitate breast_cancer metastasis .
21674725	0	discs_large_homolog_5	24,45	DLG5	52,56	discs large homolog 5	DLG5	9231	9231	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Increased expression of discs_large_homolog_5 gene -LRB- DLG5 -RRB- in ulcerative_colitis patients compared to healthy individuals .
11101902	0	dishevelled	43,54	DEP	55,58	dishevelled	DEP	13542(Tax:10090)	68268(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway .
21140450	0	dishevelled	35,46	GC-binding_factor_2	0,19	dishevelled	GC-binding factor 2	8215	9208	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GC-binding_factor_2 interacts with dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines .
11742004	0	dishevelled	111,122	LRP-6	88,93	dishevelled	LRP-6	13542(Tax:10090)	16974(Tax:10090)	Gene	Gene	independently|nmod|START_ENTITY independently|compound|END_ENTITY	Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled .
20970343	0	dishevelled	79,90	Nucleoredoxin	0,13	dishevelled	Nucleoredoxin	13542(Tax:10090)	18230(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY pool|nmod|protein retaining|dobj|pool signaling|advcl|retaining Wnt/b-catenin|acl|signaling sustains|dobj|Wnt/b-catenin sustains|nsubj|END_ENTITY	Nucleoredoxin sustains Wnt/b-catenin signaling by retaining a pool of inactive dishevelled protein .
16604061	0	dishevelled	108,119	nucleoredoxin	49,62	dishevelled	nucleoredoxin	8215	64359	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled .
16814263	0	disrupted-in-schizophrenia	27,53	DISC1	55,60	disrupted-in-schizophrenia	DISC1	27185	27185	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of disrupted-in-schizophrenia -LRB- DISC1 -RRB- in bipolar_disorder .
15381924	0	disrupted_in_schizophrenia_1	14,42	DISC1	44,49	disrupted in schizophrenia 1	DISC1	244667(Tax:10090)	244667(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of disrupted_in_schizophrenia_1 -LRB- DISC1 -RRB- protein in the adult and developing mouse brain indicates its role in neurodevelopment .
24301646	0	disrupted_in_schizophrenia_1	8,36	DISC1	38,43	disrupted in schizophrenia 1	DISC1	307940(Tax:10116)	307940(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of disrupted_in_schizophrenia_1 -LRB- DISC1 -RRB- in stress-induced prefrontal cognitive_dysfunction .
26546129	0	disrupted_in_schizophrenia_1	18,46	glycogen_synthase_kinase-3b	88,115	disrupted in schizophrenia 1	glycogen synthase kinase-3b	27185	2932	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	Beyond the brain : disrupted_in_schizophrenia_1 regulates pancreatic b-cell function via glycogen_synthase_kinase-3b .
16949685	0	distal-less	11,22	dDREF	44,49	distal-less	dDREF	37973(Tax:7227)	34328(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Drosophila distal-less negatively regulates dDREF by inhibiting its DNA binding activity .
21276595	0	divalent_metal_transport_1	20,46	SLC11A2	62,69	divalent metal transport 1	SLC11A2	4891	4891	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between divalent_metal_transport_1 encoding gene -LRB- SLC11A2 -RRB- and disease duration in amyotrophic_lateral_sclerosis .
10644324	0	divalent_metal_transporter_1	16,44	DMT1	46,50	divalent metal transporter 1	DMT1	24906(Tax:10116)	24906(Tax:10116)	Gene	Gene	Localisation|nmod|START_ENTITY Localisation|appos|END_ENTITY	Localisation of divalent_metal_transporter_1 -LRB- DMT1 -RRB- to the microvillus membrane of rat duodenal enterocytes in iron_deficiency , but to hepatocytes in iron_overload .
19655216	0	divalent_metal_transporter_1	40,68	DMT1	70,74	divalent metal transporter 1	DMT1	24906(Tax:10116)	24906(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Increased hippocampal expression of the divalent_metal_transporter_1 -LRB- DMT1 -RRB- mRNA variants 1B and + IRE and DMT1 protein after NMDA-receptor stimulation or spatial memory training .
10878606	0	dlarp	0,5	Hox	23,26	dlarp	Hox	53567(Tax:7227)	42536(Tax:7227)	Gene	Gene	START_ENTITY|appos|target target|compound|END_ENTITY	dlarp , a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions .
15579681	0	dmc1	59,63	mei5	18,22	dmc1	mei5	856926(Tax:4932)	855982(Tax:4932)	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination .
22899848	0	dmrt2a	20,26	Celf1	0,5	dmrt2a	Celf1	30129(Tax:7955)	58137(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Celf1 regulation of dmrt2a is required for somite symmetry and left-right patterning during zebrafish development .
23175770	0	dmrta2	10,16	cdkn2c	45,51	dmrta2	cdkn2c	474350(Tax:7955)	555797(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Zebrafish dmrta2 regulates the expression of cdkn2c in spermatogenesis in the adult testis .
14993190	0	dmyc	36,40	Hfp	11,14	dmyc	Hfp	31310(Tax:7227)	38173(Tax:7227)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Drosophila Hfp negatively regulates dmyc and stg to inhibit cell proliferation .
24819662	0	dock180	12,19	Rac1	32,36	dock180	Rac1	1793	5879	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|activity activity|amod|END_ENTITY	Elmo1 helps dock180 to regulate Rac1 activity and cell migration_of_ovarian_cancer .
21504746	0	dok-7	53,58	Sp1	25,28	dok-7	Sp1	285489	6667	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression plays|dobj|role plays|nsubj|END_ENTITY	The transcription factor Sp1 plays a crucial role in dok-7 gene expression .
22981232	0	dom34	9,14	hbs1	15,19	dom34	hbs1	855731(Tax:4932)	853959(Tax:4932)	Gene	Gene	Roles|nmod|START_ENTITY Roles|dep|END_ENTITY	Roles of dom34 : hbs1 in nonstop protein clearance from translocators for normal organelle protein influx .
16477641	0	don_juan	15,23	cannonball	169,179	don juan	cannonball	40838(Tax:7227)	45432(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	In Drosophila , don_juan and don_juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF_II80 cannonball while translational repression is achieved by distinct elements .
8689583	0	dop	36,39	dilute-opisthotonus	15,34	dop	dilute-opisthotonus	25017(Tax:10116)	25017(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the dilute-opisthotonus -LRB- dop -RRB- gene on chromosome 8 of the rat .
16740595	0	dopa_decarboxylase	25,43	DDC	45,48	dopa decarboxylase	DDC	1644	1644	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Intronic variants in the dopa_decarboxylase -LRB- DDC -RRB- gene are associated with smoking behavior in European-Americans and African-Americans .
17968140	0	dopa_decarboxylase	28,46	Ddc	48,51	dopa decarboxylase	Ddc	35190(Tax:7227)	35190(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nucleotide variation at the dopa_decarboxylase -LRB- Ddc -RRB- gene in natural populations of Drosophila_melanogaster .
4209419	0	dopa_decarboxylase	92,110	alpha-methyl_dopa	71,88	dopa decarboxylase	alpha-methyl dopa	35190(Tax:7227)	35188(Tax:7227)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	The selection for mutants in Drosophila_melanogaster hypersensitive to alpha-methyl_dopa , a dopa_decarboxylase inhibitor .
4852471	0	dopa_decarboxylase	14,32	kallikrein	36,46	dopa decarboxylase	kallikrein	1644	9622	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dopa_decarboxylase by kallikrein .
15892717	0	dopachrome_tautomerase	32,54	MITF	67,71	dopachrome tautomerase	MITF	1638	4286	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Dynamic regulation of the human dopachrome_tautomerase promoter by MITF , ER-alpha and chromatin remodelers during proliferation and senescence of human melanocytes .
8048919	0	dopachrome_tautomerase	56,78	TRP2	47,51	dopachrome tautomerase	TRP2	13190(Tax:10090)	104042(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Functional analysis of the slaty gene product -LRB- TRP2 -RRB- as dopachrome_tautomerase and the effect of a point mutation on its catalytic function .
7886003	0	dopachrome_tautomerase	49,71	brown	10,15	dopachrome tautomerase	brown	13190(Tax:10090)	22178(Tax:10090)	Gene	Gene	locus|nmod|START_ENTITY locus|nsubj|END_ENTITY	The mouse brown -LRB- b -RRB- locus protein functions as a dopachrome_tautomerase .
17535813	0	dopamine-D2_receptor	71,91	CC2D1A	35,41	dopamine-D2 receptor	CC2D1A	1813	54862	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Differential repression by freud-1 / CC2D1A at a polymorphic site in the dopamine-D2_receptor gene .
6764083	0	dopamine-beta-hydroxylase	7,32	DBH	34,37	dopamine-beta-hydroxylase	DBH	103347199	103347199	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Plasma dopamine-beta-hydroxylase -LRB- DBH -RRB- activity in two kinds of acute stress in rabbits .
1635665	0	dopamine-beta-hydroxylase	70,95	neuropeptide_Y	21,35	dopamine-beta-hydroxylase	neuropeptide Y	280758(Tax:9913)	504216(Tax:9913)	Gene	Gene	activity|nmod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of dopamine-beta-hydroxylase .
9428587	0	dopamine-releasing_protein	17,43	DARP	45,49	dopamine-releasing protein	DARP	200539	200539	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of dopamine-releasing_protein -LRB- DARP -RRB- in cerebrospinal fluid of patients with neurological_disorders .
12488059	0	dopamine_D1_receptor	31,51	DRD1	58,62	dopamine D1 receptor	DRD1	1812	1812	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage disequilibrium between dopamine_D1_receptor gene -LRB- DRD1 -RRB- and bipolar_disorder .
21181138	0	dopamine_D1_receptor	38,58	DRD1	60,64	dopamine D1 receptor	DRD1	1812	1812	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of genetic variations in the dopamine_D1_receptor -LRB- DRD1 -RRB- gene and antipsychotics-induced tardive_dyskinesia in schizophrenia .
8837716	0	dopamine_D1_receptor	76,96	DRD1	98,102	dopamine D1 receptor	DRD1	1812	1812	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Systematic screening for mutations in the 5 ' - regulatory region of the human dopamine_D1_receptor -LRB- DRD1 -RRB- gene in patients with schizophrenia and bipolar_affective_disorder .
21777508	0	dopamine_D2_receptor	4,24	Akt	35,38	dopamine D2 receptor	Akt	1813	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The dopamine_D2_receptor regulates Akt and GSK-3 via Dvl-3 .
11261743	0	dopamine_D2_receptor	23,43	DRD2	50,54	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between dopamine_D2_receptor gene -LRB- DRD2 -RRB- and human intelligence .
11353448	0	dopamine_D2_receptor	28,48	DRD2	50,54	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Relationship between Taq1 A dopamine_D2_receptor -LRB- DRD2 -RRB- polymorphism and prolactin response to bromperidol .
1351040	0	dopamine_D2_receptor	30,50	DRD2	57,61	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A rare FokI RFLP in the human dopamine_D2_receptor gene -LRB- DRD2 -RRB- .
18821566	0	dopamine_D2_receptor	8,28	DRD2	35,39	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SNPs in dopamine_D2_receptor gene -LRB- DRD2 -RRB- and norepinephrine_transporter gene -LRB- NET -RRB- are associated with continuous performance task -LRB- CPT -RRB- phenotypes in ADHD children and their families .
22521396	0	dopamine_D2_receptor	24,44	DRD2	46,50	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between the dopamine_D2_receptor -LRB- DRD2 -RRB- polymorphism and the personality traits of healthy Japanese participants .
22536882	0	dopamine_D2_receptor	12,32	DRD2	34,38	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of dopamine_D2_receptor -LRB- DRD2 -RRB- gene polymorphisms in cannabinoid addicts .
22798433	0	dopamine_D2_receptor	92,112	DRD2	119,123	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The moderating effect of alcohol-specific parental rule-setting on the relation between the dopamine_D2_receptor gene -LRB- DRD2 -RRB- , the - opioid receptor gene -LRB- OPRM1 -RRB- and alcohol use in young adolescents .
24157248	0	dopamine_D2_receptor	19,39	DRD2	41,45	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Methylation of the dopamine_D2_receptor -LRB- DRD2 -RRB- gene promoter in women with a bulimia-spectrum_disorder : associations with borderline_personality_disorder and exposure to childhood abuse .
24469773	0	dopamine_D2_receptor	38,58	DRD2	60,64	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Assessment of association between the dopamine_D2_receptor -LRB- DRD2 -RRB- polymorphism and neurodevelopment of children exposed to lead .
24634060	0	dopamine_D2_receptor	91,111	DRD2	118,122	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Altered regional brain volumes in elderly carriers of a risk variant for drug_abuse in the dopamine_D2_receptor gene -LRB- DRD2 -RRB- .
8679787	0	dopamine_D2_receptor	68,88	DRD2	95,99	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between alcoholism and multiple polymorphisms at the dopamine_D2_receptor gene -LRB- DRD2 -RRB- in three distinct Taiwanese populations .
8845863	0	dopamine_D2_receptor	4,24	DRD2	26,30	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The dopamine_D2_receptor -LRB- DRD2 -RRB- gene : a genetic risk factor in smoking .
9118359	0	dopamine_D2_receptor	145,165	DRD2	167,171	dopamine D2 receptor	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants of the human obesity -LRB- OB -RRB- gene : association with body mass index in young women , psychiatric symptoms , and interaction with the dopamine_D2_receptor -LRB- DRD2 -RRB- gene .
19503018	0	dopamine_D3_receptor	50,70	DRD3	72,76	dopamine D3 receptor	DRD3	1814	1814	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis between polymorphisms in the dopamine_D3_receptor -LRB- DRD3 -RRB- gene and cocaine_dependence .
19897343	0	dopamine_D3_receptor	4,24	DRD3	26,30	dopamine D3 receptor	DRD3	1814	1814	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The dopamine_D3_receptor -LRB- DRD3 -RRB- gene and risk of schizophrenia : case-control studies and an updated meta-analysis .
9491816	0	dopamine_D3_receptor	4,24	DRD3	26,30	dopamine D3 receptor	DRD3	1814	1814	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The dopamine_D3_receptor -LRB- DRD3 -RRB- Ser9Gly polymorphism and schizophrenia : a haplotype relative risk study and association with clozapine response .
23242790	0	dopamine_D3_receptor	70,90	neurofibromin	12,25	dopamine D3 receptor	neurofibromin	13490(Tax:10090)	18015(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Hippocampal neurofibromin and amyloid_precursor_protein expression in dopamine_D3_receptor knock-out mice following passive avoidance conditioning .
17508995	0	dopamine_D4_receptor	21,41	CNR1	94,98	dopamine D4 receptor	CNR1	1815	1268	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the dopamine_D4_receptor gene -LRB- DRD4 VNTR -RRB- and cannabinoid CB1 receptor gene -LRB- CNR1 -RRB- are not strongly related to cue-reactivity after alcohol exposure .
9399690	0	dopamine_D4_receptor	51,71	D4DR	73,77	dopamine D4 receptor	D4DR	1815	1815	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Additional evidence for an association between the dopamine_D4_receptor -LRB- D4DR -RRB- exon III repeat polymorphism and the human personality trait of Novelty_Seeking .
10570917	0	dopamine_D4_receptor	56,76	DRD4	78,82	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel polymorphisms in the upstream region of the human dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
10581493	0	dopamine_D4_receptor	48,68	DRD4	75,79	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tandem duplication polymorphism upstream of the dopamine_D4_receptor gene -LRB- DRD4 -RRB- .
10750051	0	dopamine_D4_receptor	27,47	DRD4	49,53	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evolution of exon 1 of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene in primates .
10898895	0	dopamine_D4_receptor	39,59	DRD4	61,65	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A haplotype relative risk study of the dopamine_D4_receptor -LRB- DRD4 -RRB- exon III repeat polymorphism and attention deficit_hyperactivity_disorder -LRB- ADHD -RRB- .
11032387	0	dopamine_D4_receptor	74,94	DRD4	101,105	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine_D4_receptor gene -LRB- DRD4 -RRB- with attention_deficit_hyperactivity_disorder -LRB- ADHD -RRB- .
11358133	0	dopamine_D4_receptor	73,93	DRD4	95,99	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genotyping the -521 C/T functional polymorphism in the promoter region of dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
11583250	0	dopamine_D4_receptor	23,43	DRD4	50,54	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of the dopamine_D4_receptor gene -LRB- DRD4 -RRB- and the serotonin transporter promoter gene -LRB- 5-HTTLPR -RRB- with temperament in 12-month-old infants .
11803443	0	dopamine_D4_receptor	37,57	DRD4	59,63	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Further evidence for the role of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene in attachment disorganization : interaction of the exon III 48-bp repeat and the -521 _ C/T promoter polymorphisms .
12116162	0	dopamine_D4_receptor	89,109	DRD4	111,115	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Direct haplotype detection of adjacent polymorphic sites in the regulatory region of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
14755455	0	dopamine_D4_receptor	49,69	DRD4	71,75	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	A dyslexia susceptibility locus -LRB- DYX7 -RRB- linked to dopamine_D4_receptor -LRB- DRD4 -RRB- region on chromosome 11p15 .5 .
15078164	0	dopamine_D4_receptor	110,130	DRD4	132,136	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Capillary electrophoresis study on DNA-protein complex formation in the polymorphic 5 ' upstream region of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
15206004	0	dopamine_D4_receptor	15,35	DRD4	37,41	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of dopamine_D4_receptor -LRB- DRD4 -RRB- gene with attention-deficit/hyperactivity _ disorder -LRB- ADHD -RRB- in a high-risk community sample : a longitudinal study from birth to 11 years of age .
16619053	0	dopamine_D4_receptor	21,41	DRD4	48,52	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the dopamine_D4_receptor gene -LRB- DRD4 -RRB- contribute to individual differences in human sexual_behavior : desire , arousal and sexual function .
16815339	0	dopamine_D4_receptor	20,40	DRD4	42,46	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between dopamine_D4_receptor -LRB- DRD4 -RRB- gene polymorphisms and novelty-elicited auditory event-related potentials in preschool children .
16917940	0	dopamine_D4_receptor	24,44	DRD4	46,50	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exon 3 polymorphisms of dopamine_D4_receptor -LRB- DRD4 -RRB- gene and attention_deficit_hyperactivity_disorder in Chinese children .
17028370	4	dopamine_D4_receptor	489,509	DRD4	511,515	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	We highlight the two most prominent findings with the dopamine_D4_receptor -LRB- DRD4 -RRB- gene and the dopamine_transporter -LRB- DAT1 -RRB- gene , and their implications for the understanding of the cellular and neurobiological basis for ADHD .
17387332	0	dopamine_D4_receptor	25,45	DRD4	47,51	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the dopamine_D4_receptor -LRB- DRD4 -RRB- gene and smoking cessation : follow-up of a randomised clinical trial of transdermal nicotine patch .
17474081	0	dopamine_D4_receptor	24,44	DRD4	51,55	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novelty seeking and the dopamine_D4_receptor gene -LRB- DRD4 -RRB- revisited in Asians : haplotype characterization and relevance of the 2-repeat allele .
17574217	0	dopamine_D4_receptor	19,39	DRD4	41,45	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene and approach-related personality traits : meta-analysis and new data .
18331372	0	dopamine_D4_receptor	48,68	DRD4	70,74	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Smoking status moderates the association of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene VNTR polymorphism with selective processing of smoking-related cues .
19602428	0	dopamine_D4_receptor	30,50	DRD4	52,56	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Minor genetic variants of the dopamine_D4_receptor -LRB- DRD4 -RRB- polymorphism are associated with novelty seeking in healthy Japanese subjects .
22198971	0	dopamine_D4_receptor	83,103	DRD4	105,109	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Religion priming differentially increases prosocial behavior among variants of the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
22564179	0	dopamine_D4_receptor	117,137	DRD4	144,148	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Double dissociation between lab measures of inattention and impulsivity and the dopamine_transporter gene -LRB- DAT1 -RRB- and dopamine_D4_receptor gene -LRB- DRD4 -RRB- .
24102377	0	dopamine_D4_receptor	93,113	DRD4	115,119	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mothers ' prenatal stress and their children 's antisocial outcomes -- a moderating role for the dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
7831304	0	dopamine_D4_receptor	15,35	DRD4	37,41	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variability of dopamine_D4_receptor -LRB- DRD4 -RRB- gene sequence within and among nonhuman primate species .
8723054	0	dopamine_D4_receptor	32,52	DRD4	54,58	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of imprinting of the human dopamine_D4_receptor -LRB- DRD4 -RRB- gene .
9034534	0	dopamine_D4_receptor	4,24	DRD4	31,35	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The dopamine_D4_receptor gene -LRB- DRD4 -RRB- is not associated with alcoholism in three Taiwanese populations : six polymorphisms tested separately and as haplotypes .
9711064	0	dopamine_D4_receptor	51,71	DRD4	73,77	dopamine D4 receptor	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparison of a hypervariable segment in the human dopamine_D4_receptor -LRB- DRD4 -RRB- gene between the Japanese and Mongolian populations .
18303015	0	dopamine_D4_receptor	31,51	KLHL12	12,18	dopamine D4 receptor	KLHL12	1815	59349	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	BTB Protein KLHL12 targets the dopamine_D4_receptor for ubiquitination by a Cul3-based E3 ligase .
22827965	0	dopamine_D5_receptor	29,49	BDNF	68,72	dopamine D5 receptor	BDNF	25195(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	A physiological role for the dopamine_D5_receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex .
11304828	0	dopamine_D5_receptor	21,41	DRD5	48,52	dopamine D5 receptor	DRD5	1816	1816	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Markers close to the dopamine_D5_receptor gene -LRB- DRD5 -RRB- show significant association with schizophrenia but not bipolar_disorder .
12700316	0	dopamine_D5_receptor	12,32	DRD5	34,38	dopamine D5 receptor	DRD5	1816	1816	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the dopamine_D5_receptor -LRB- DRD5 -RRB- as a susceptibility gene for cervical dystonia .
14755441	0	dopamine_D5_receptor	21,41	DRD5	43,47	dopamine D5 receptor	DRD5	1816	1816	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the dopamine_D5_receptor -LRB- DRD5 -RRB- gene and ADHD .
20827341	0	dopamine_b-hydroxylase	84,106	DBH	108,111	dopamine b-hydroxylase	DBH	25699(Tax:10116)	25699(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase -LRB- TH -RRB- and dopamine_b-hydroxylase -LRB- DBH -RRB- gene expression in immobilization-stressed rats and PC12 cells .
10490716	0	dopamine_beta-hydroxylase	96,121	DBH	128,131	dopamine beta-hydroxylase	DBH	1621	1621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No evidence for allelic association between schizophrenia and a functional variant of the human dopamine_beta-hydroxylase gene -LRB- DBH -RRB- .
729170	0	dopamine_beta-hydroxylase	6,31	DBH	33,36	dopamine beta-hydroxylase	DBH	1621	1621	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Serum dopamine_beta-hydroxylase -LRB- DBH -RRB- activity in acute myocardial_infarction .
9259372	0	dopamine_beta-hydroxylase	51,76	DBH	83,86	dopamine beta-hydroxylase	DBH	1621	1621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Population genetics of a functional variant of the dopamine_beta-hydroxylase gene -LRB- DBH -RRB- .
7418270	0	dopamine_beta-hydroxylase	6,31	D_beta_H	33,41	dopamine beta-hydroxylase	D beta H	1621	1621	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum dopamine_beta-hydroxylase -LRB- D_beta_H -RRB- levels during tilting in patients with spinal_cord_injuries .
18338249	0	dopamine_beta-hydroxylase	70,95	GATA-3	21,27	dopamine beta-hydroxylase	GATA-3	1621	2625	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Transcription factor GATA-3 regulates the transcriptional activity of dopamine_beta-hydroxylase by interacting with Sp1 and AP4 .
18190898	0	dopamine_beta-hydroxylase	18,43	early_growth_response_gene_1	66,94	dopamine beta-hydroxylase	early growth response gene 1	25699(Tax:10116)	24330(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of rat dopamine_beta-hydroxylase gene transcription by early_growth_response_gene_1 -LRB- Egr1 -RRB- .
3180847	0	dopamine_beta_hydroxylase	26,51	DBH	53,56	dopamine beta hydroxylase	DBH	1621	1621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human dopamine_beta_hydroxylase -LRB- DBH -RRB- gene to chromosome 9q34 .
17310237	0	dopamine_receptor_D1	19,39	DRD1	46,50	dopamine receptor D1	DRD1	1812	1812	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the dopamine_receptor_D1 gene , DRD1 , with inattention symptoms in families selected for reading problems .
25761959	0	dopamine_receptor_D2	30,50	DRD2	52,56	dopamine receptor D2	DRD2	1813	1813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The C957T polymorphism in the dopamine_receptor_D2 -LRB- DRD2 -RRB- gene modulates domain-general category learning .
12497615	0	dopamine_receptor_D4	24,44	DRD4	46,50	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Association between the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene and obsessive-compulsive_disorder .
15077199	0	dopamine_receptor_D4	51,71	DRD4	73,77	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The genetic architecture of selection at the human dopamine_receptor_D4 -LRB- DRD4 -RRB- gene locus .
16332176	0	dopamine_receptor_D4	69,89	DRD4	91,95	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Identification and characterization of tandem repeats in exon III of dopamine_receptor_D4 -LRB- DRD4 -RRB- genes from different mammalian species .
16495430	0	dopamine_receptor_D4	74,94	DRD4	96,100	dopamine receptor D4	DRD4	1815	101906668	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of a tandem repeat in exon III of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene in cetaceans .
16887146	0	dopamine_receptor_D4	25,45	DRD4	52,56	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic structure of the dopamine_receptor_D4 gene -LRB- DRD4 -RRB- and lack of association with schizophrenia in Japanese patients .
19713452	0	dopamine_receptor_D4	81,101	DRD4	103,107	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assortative human pair-bonding for partner ancestry and allelic variation of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene .
20359751	0	dopamine_receptor_D4	51,71	DRD4	73,77	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of exon 3 VNTR polymorphism of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene with alcoholism in Mexican Americans .
20644990	0	dopamine_receptor_D4	4,24	DRD4	31,35	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The dopamine_receptor_D4 gene -LRB- DRD4 -RRB- moderates family environmental effects on ADHD .
23986684	0	dopamine_receptor_D4	62,82	DRD4	89,93	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association between creativity and 7R polymorphism in the dopamine_receptor_D4 gene -LRB- DRD4 -RRB- .
8353495	0	dopamine_receptor_D4	37,57	DRD4	59,63	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A hypervariable segment in the human dopamine_receptor_D4 -LRB- DRD4 -RRB- gene .
9491811	0	dopamine_receptor_D4	19,39	DRD4	41,45	dopamine receptor D4	DRD4	1815	1815	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the dopamine_receptor_D4 -LRB- DRD4 -RRB- gene with a refined phenotype of attention_deficit_hyperactivity_disorder -LRB- ADHD -RRB- : a family-based approach .
19482058	0	dopamine_receptor_D4	86,106	Drd4	113,117	dopamine receptor D4	Drd4	25432(Tax:10116)	25432(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thyroid_hormone and adrenergic signaling interact to control pineal expression of the dopamine_receptor_D4 gene -LRB- Drd4 -RRB- .
16734940	0	dopamine_receptor_interacting_protein	19,56	NEF3	63,67	dopamine receptor interacting protein	NEF3	85406	4741	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the dopamine_receptor_interacting_protein gene , NEF3 , with early response to antipsychotic medication .
12568728	0	dopamine_receptor_regulating_factor	65,100	DRRF	102,106	dopamine receptor regulating factor	DRRF	118445(Tax:10090)	118445(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and promoter characterization of the murine dopamine_receptor_regulating_factor -LRB- DRRF -RRB- gene .
18472212	0	dopamine_receptor_regulating_factor	39,74	DRRF	76,80	dopamine receptor regulating factor	DRRF	118445(Tax:10090)	118445(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional auto-regulation of the dopamine_receptor_regulating_factor -LRB- DRRF -RRB- gene .
24926820	0	dopamine_receptor_type-2	18,42	DRD2	44,48	dopamine receptor type-2	DRD2	1813	1813	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Activation of the dopamine_receptor_type-2 -LRB- DRD2 -RRB- promoter by 9-cis retinoic_acid in a cellular model of Cushing 's _ disease mediates the inhibition of cell proliferation and ACTH secretion without a complete corticotroph-to-melanotroph transdifferentiation .
21176997	0	dopamine_transporter	9,29	BDNF	60,64	dopamine transporter	BDNF	6531	627	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Striatal dopamine_transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration .
26048990	0	dopamine_transporter	61,81	Ctr9	0,4	dopamine transporter	Ctr9	6531	9646	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Ctr9 , a protein in the transcription complex Paf1 , regulates dopamine_transporter activity at the plasma membrane .
16490314	0	dopamine_transporter	33,53	DAT	54,57	dopamine transporter	DAT	6531	6531	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization of the neuronal dopamine_transporter DAT in human blood platelets .
16733058	0	dopamine_transporter	8,28	DAT	30,33	dopamine transporter	DAT	788410(Tax:9913)	788410(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of dopamine_transporter -LRB- DAT -RRB- in dopamine transport across the nasal mucosa .
19960520	0	dopamine_transporter	16,36	DAT	38,41	dopamine transporter	DAT	6531	6531	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the dopamine_transporter -LRB- DAT -RRB- in the development of PTSD in preschool children .
10889530	0	dopamine_transporter	82,102	DAT1	109,113	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Systematic screening for DNA sequence variation in the coding region of the human dopamine_transporter gene -LRB- DAT1 -RRB- .
11911442	0	dopamine_transporter	35,55	DAT1	57,61	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The VNTR polymorphism of the human dopamine_transporter -LRB- DAT1 -RRB- gene affects gene expression .
1478653	0	dopamine_transporter	6,26	DAT1	33,37	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human dopamine_transporter gene -LRB- DAT1 -RRB- maps to chromosome 5p15 .3 and displays a VNTR .
15683546	0	dopamine_transporter	67,87	DAT1	94,98	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transient expression analysis of allelic variants of a VNTR in the dopamine_transporter gene -LRB- DAT1 -RRB- .
15749835	0	dopamine_transporter	166,186	DAT1	188,192	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3 ' non-coding polymorphic region of the human dopamine_transporter -LRB- DAT1 -RRB- gene .
16123773	0	dopamine_transporter	20,40	DAT1	42,46	dopamine transporter	DAT1	6531	6531	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between dopamine_transporter -LRB- DAT1 -RRB- genotype , left-sided inattention , and an enhanced response to methylphenidate in attention-deficit_hyperactivity_disorder .
16702979	0	dopamine_transporter	39,59	DAT1	61,65	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A 40-basepair VNTR polymorphism in the dopamine_transporter -LRB- DAT1 -RRB- gene and the rapid response to antidepressant treatment .
17712789	0	dopamine_transporter	64,84	DAT1	91,95	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Diversity and relationship between Iranian ethnic groups : human dopamine_transporter gene -LRB- DAT1 -RRB- VNTR genotyping .
19120712	0	dopamine_transporter	44,64	DAT1	66,70	dopamine transporter	DAT1	6531	6531	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of ADHD , tics , and anxiety with dopamine_transporter -LRB- DAT1 -RRB- genotype in autism_spectrum_disorder .
19352220	0	dopamine_transporter	61,81	DAT1	83,87	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between harmful alcohol consumption behavior and dopamine_transporter -LRB- DAT1 -RRB- gene polymorphisms in a male Finnish population .
20141587	0	dopamine_transporter	4,24	DAT1	31,35	dopamine transporter	DAT1	6531	6531	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The dopamine_transporter gene -LRB- DAT1 -RRB- polymorphism is associated with premature_ejaculation .
22564179	0	dopamine_transporter	80,100	DAT1	107,111	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Double dissociation between lab measures of inattention and impulsivity and the dopamine_transporter gene -LRB- DAT1 -RRB- and dopamine_D4_receptor gene -LRB- DRD4 -RRB- .
22646917	0	dopamine_transporter	15,35	DAT1	37,41	dopamine transporter	DAT1	6531	6531	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of dopamine_transporter -LRB- DAT1 -RRB- genotype and maltreatment for ADHD : a latent class analysis .
22819977	0	dopamine_transporter	54,74	DAT1	76,80	dopamine transporter	DAT1	6531	6531	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	The androgen_receptor facilitates inhibition of human dopamine_transporter -LRB- DAT1 -RRB- reporter gene expression by HESR1 and HESR2 via the variable number of tandem repeats .
24432029	0	dopamine_transporter	55,75	DAT1	77,81	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The presence of both serotonin 1A receptor -LRB- HTR1A -RRB- and dopamine_transporter -LRB- DAT1 -RRB- gene variants increase the risk of borderline_personality_disorder .
25915480	0	dopamine_transporter	24,44	DAT1	51,55	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between the dopamine_transporter gene -LRB- DAT1 -RRB- and attention_deficit_hyperactivity_disorder-related traits in healthy adults .
25915480	0	dopamine_transporter	24,44	DAT1	51,55	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between the dopamine_transporter gene -LRB- DAT1 -RRB- and attention_deficit_hyperactivity_disorder-related traits in healthy adults .
7557351	0	dopamine_transporter	38,58	DAT1	65,69	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Population genetic study of the human dopamine_transporter gene -LRB- DAT1 -RRB- .
7590757	0	dopamine_transporter	29,49	DAT1	17,21	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Amplification of DAT1 -LRB- human dopamine_transporter gene -RRB- 3 ' variable region in the Japanese population .
9433566	0	dopamine_transporter	35,55	DAT1	62,66	dopamine transporter	DAT1	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Linkage disequilibrium between the dopamine_transporter gene -LRB- DAT1 -RRB- and bipolar_disorder : extending the transmission disequilibrium test -LRB- TDT -RRB- to examine genetic heterogeneity .
17519329	0	dopamine_transporter	26,46	GPR37	0,5	dopamine transporter	GPR37	13162(Tax:10090)	14763(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	GPR37 associates with the dopamine_transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs .
21144620	0	dopamine_transporter	9,29	Gdnf	54,58	dopamine transporter	Gdnf	13162(Tax:10090)	14573(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Enhanced dopamine_transporter activity in middle-aged Gdnf heterozygous mice .
12177201	0	dopamine_transporter	105,125	Hic-5	51,56	dopamine transporter	Hic-5	6531	7041	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine_transporter .
21957239	0	dopamine_transporter	61,81	Rin	38,41	dopamine transporter	Rin	6531	6014	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The plasma membrane-associated GTPase Rin interacts with the dopamine_transporter and is required for protein kinase C-regulated dopamine_transporter trafficking .
10418689	0	dopamine_transporter	70,90	SLC6A3	97,103	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Global variation of a 40-bp VNTR in the 3 ' - untranslated region of the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
11739616	0	dopamine_transporter	4,24	SLC6A3	31,37	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The dopamine_transporter gene -LRB- SLC6A3 -RRB- variable number of tandem repeats domain enhances transcription in dopamine neurons .
15608954	0	dopamine_transporter	49,69	SLC6A3	76,82	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association between VNTR polymorphism of dopamine_transporter gene -LRB- SLC6A3 -RRB- and schizophrenia in a Brazilian sample .
16963468	0	dopamine_transporter	36,56	SLC6A3	63,69	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	5 ' and 3 ' region variability in the dopamine_transporter gene -LRB- SLC6A3 -RRB- , pesticide exposure and Parkinson 's _ disease risk : a hypothesis-generating study .
18094849	0	dopamine_transporter	65,85	SLC6A3	92,98	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association analysis between a VNTR intron 8 polymorphism of the dopamine_transporter gene -LRB- SLC6A3 -RRB- and obsessive - _ compulsive_disorder in a Brazilian sample .
18361424	0	dopamine_transporter	69,89	SLC6A3	96,102	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Family based association study of pediatric bipolar_disorder and the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
18563707	0	dopamine_transporter	111,131	SLC6A3	138,144	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Pharmacogenetics of methylphenidate response in attention_deficit / hyperactivity_disorder : association with the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
19766158	0	dopamine_transporter	89,109	SLC6A3	111,117	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Genetic polymorphisms in the dopamine-2_receptor -LRB- DRD2 -RRB- , dopamine-3_receptor -LRB- DRD3 -RRB- , and dopamine_transporter -LRB- SLC6A3 -RRB- genes in schizophrenia : Data from an association study .
20091113	0	dopamine_transporter	17,37	SLC6A3	39,45	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms in dopamine_transporter -LRB- SLC6A3 -RRB- are associated with stimulant effects of D-amphetamine : an exploratory pharmacogenetic study using healthy volunteers .
20332413	0	dopamine_transporter	57,77	SLC6A3	84,90	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association between a 3 ` UTR VNTR polymorphism of dopamine_transporter gene -LRB- SLC6A3 -RRB- and ADHD in a Brazilian sample of adult patients .
21050355	0	dopamine_transporter	76,96	SLC6A3	103,109	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relationship between premature_ejaculation and genetic polymorphisms of the dopamine_transporter gene -LRB- SLC6A3 -RRB- .
23162299	0	dopamine_transporter	59,79	SLC6A3	86,92	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association between the G-660C polymorphism in the dopamine_transporter gene -LRB- SLC6A3 -RRB- and schizophrenia in the Iranian population .
8825631	0	dopamine_transporter	4,24	SLC6A3	39,45	dopamine transporter	SLC6A3	6531	6531	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The dopamine_transporter protein gene -LRB- SLC6A3 -RRB- : primary linkage mapping and linkage studies in Tourette_syndrome .
21295544	0	dopamine_transporter	18,38	Secretory_Carrier_Membrane_Protein_2	59,95	dopamine transporter	Secretory Carrier Membrane Protein 2	6531	10066	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of the dopamine_transporter by interaction with Secretory_Carrier_Membrane_Protein_2 .
20643191	0	dopamine_transporter	22,42	Syntaxin_1A	0,11	dopamine transporter	Syntaxin 1A	24898(Tax:10116)	116470(Tax:10116)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Syntaxin_1A regulates dopamine_transporter activity , phosphorylation and surface expression .
17234899	0	dopamine_transporter	56,76	Trace_amine-associated_receptor_1	0,33	dopamine transporter	Trace amine-associated receptor 1	574143(Tax:9544)	708944(Tax:9544)	Gene	Gene	modulator|nmod|START_ENTITY modulator|nsubj|END_ENTITY	Trace_amine-associated_receptor_1 is a modulator of the dopamine_transporter .
12958153	0	dopamine_transporter	14,34	alpha-synuclein	47,62	dopamine transporter	alpha-synuclein	6531	6622	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Modulation of dopamine_transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress .
19419578	0	dopamine_transporter	14,34	carboxypeptidase_E	47,65	dopamine transporter	carboxypeptidase E	6531	1363	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of dopamine_transporter activity by carboxypeptidase_E .
11238713	0	dopamine_transporter	27,47	mGluR5	96,102	dopamine transporter	mGluR5	24898(Tax:10116)	14805(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Modulation of the neuronal dopamine_transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes .
20074437	0	dopamine_transporter	115,135	substance_P	93,104	dopamine transporter	substance P	6531	6863	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Candidate-gene approach in fibromyalgia syndrome : association analysis of the genes encoding substance_P receptor , dopamine_transporter and alpha1-antitrypsin .
14706637	0	dopamine_transporter	72,92	zinc_finger_protein_161	6,29	dopamine transporter	zinc finger protein 161	6531	7716	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Human zinc_finger_protein_161 , a novel transcriptional activator of the dopamine_transporter .
18607068	0	doppel	58,64	Dpl	66,69	doppel	Dpl	23627	23627	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Altered cellular distribution and sub-cellular sorting of doppel -LRB- Dpl -RRB- protein in human astrocytoma cell lines .
15274317	0	doppel	50,56	PRND	63,67	doppel	PRND	23627	23627	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Differential expression of the prion-like protein doppel gene -LRB- PRND -RRB- in astrocytomas : a new molecular marker potentially involved in tumor progression .
9065698	0	dor	47,50	deep_orange	34,45	dor	deep orange	31118(Tax:7227)	31118(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular characterization of the deep_orange -LRB- dor -RRB- gene of Drosophila_melanogaster .
16086746	0	double-RNA-specific_adenosine_deaminase	4,43	DSRAD	45,50	double-RNA-specific adenosine deaminase	DSRAD	103	103	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The double-RNA-specific_adenosine_deaminase -LRB- DSRAD -RRB- gene in dyschromatosis symmetrica hereditaria patients : two novel mutations and one previously described .
16530423	0	doublecortin	35,47	DCX	49,52	doublecortin	DCX	1641	1641	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|appos|END_ENTITY	Site-specific dephosphorylation of doublecortin -LRB- DCX -RRB- by protein_phosphatase_1 -LRB- PP1 -RRB- .
16814268	0	doublecortin	34,46	DCX	48,51	doublecortin	DCX	752002(Tax:59729)	752002(Tax:59729)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The distribution of expression of doublecortin -LRB- DCX -RRB- mRNA and protein in the zebra_finch brain .
16530423	0	doublecortin	35,47	protein_phosphatase_1	57,78	doublecortin	protein phosphatase 1	1641	5464	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Site-specific dephosphorylation of doublecortin -LRB- DCX -RRB- by protein_phosphatase_1 -LRB- PP1 -RRB- .
24582561	0	doublecortin-like_protein_kinase	25,57	JDP2	104,108	doublecortin-like protein kinase	JDP2	572548(Tax:7955)	436766(Tax:7955)	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Nuclear translocation of doublecortin-like_protein_kinase and phosphorylation of a transcription factor JDP2 .
12361959	0	doublesex	126,135	intersex	0,8	doublesex	intersex	40940(Tax:7227)	45881(Tax:7227)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	intersex , a gene required for female sexual development in Drosophila , is expressed in both sexes and functions together with doublesex to regulate terminal differentiation .
17523919	0	down-regulated_in_renal_cell_carcinoma_1	34,74	DRR1	28,32	down-regulated in renal cell carcinoma 1	DRR1	11170	11170	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Soluble expression of human DRR1 -LRB- down-regulated_in_renal_cell_carcinoma_1 -RRB- in Escherichia_coli and preparation of its polyclonal antibodies .
17562172	0	downstream_regulatory_element_antagonist_modulator	16,66	DREAM	68,73	downstream regulatory element antagonist modulator	DREAM	65199(Tax:10116)	65199(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of downstream_regulatory_element_antagonist_modulator -LRB- DREAM -RRB- in rat spinal cord and upregulation of its expression during inflammatory pain .
23459071	0	doxorubicin_resistance	30,52	Mad1	0,4	doxorubicin resistance	Mad1	5243	4084	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Mad1 mediates hypoxia-induced doxorubicin_resistance in colon_cancer cells by inhibiting mitochondrial function .
24709011	0	doxorubicin_resistance	37,59	interleukin-6	64,77	doxorubicin resistance	interleukin-6	5243	3569	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	TLR5 activation by flagellin induces doxorubicin_resistance via interleukin-6 -LRB- IL-6 -RRB- expression in two multiple myeloma cells .
19004858	0	dsh	14,17	PTK7	0,4	dsh	PTK7	399301(Tax:8355)	398862(Tax:8355)	Gene	Gene	START_ENTITY|nsubj|recruits recruits|compound|END_ENTITY	PTK7 recruits dsh to regulate neural crest migration .
21387288	0	dual-specificity_phosphatase	17,45	DUSP6	49,54	dual-specificity phosphatase	DUSP6	1848	1848	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Tumor suppressor dual-specificity_phosphatase 6 -LRB- DUSP6 -RRB- impairs cell invasion and epithelial-mesenchymal transition -LRB- EMT -RRB- - associated phenotype .
24339725	0	dual-specificity_phosphatase_1	36,66	superoxide_dismutase_1	12,34	dual-specificity phosphatase 1	superoxide dismutase 1	1843	6647	Gene	Gene	Analysis|amod|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of superoxide_dismutase_1 , dual-specificity_phosphatase_1 , and transforming_growth_factor , _ beta_1 genes expression in keratoconic and non-keratoconic corneas .
20358250	0	dual-specificity_phosphatase_13A	63,95	apoptosis_signal-regulating_kinase_1	23,59	dual-specificity phosphatase 13A	apoptosis signal-regulating kinase 1	51207	4217	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Positive regulation of apoptosis_signal-regulating_kinase_1 by dual-specificity_phosphatase_13A .
22430215	0	dual-specificity_phosphatase_4	91,121	KRAS	10,14	dual-specificity phosphatase 4	KRAS	1846	3845	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity_phosphatase_4 -LRB- DUSP4/MKP2 -RRB- resulting in nuclear ERK1/2 inhibition .
18938227	0	dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A	28,89	septin_4	135,143	dual-specificity tyrosine phosphorylation-regulated kinase 1A	septin 4	1859	5414	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The Down syndrome candidate dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A phosphorylates the neurodegeneration-related septin_4 .
19808064	0	dual_leucine_zipper-bearing_kinase	8,42	DLK/MUK/ZPK	44,55	dual leucine zipper-bearing kinase	DLK/MUK/ZPK	25579(Tax:10116)	25579(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of dual_leucine_zipper-bearing_kinase -LRB- DLK/MUK/ZPK -RRB- in axonal growth .
20709675	0	dual_leucine_zipper_kinase	44,70	DLK	71,74	dual leucine zipper kinase	DLK	7786	7786	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Regulation of the JNK signaling pathway by dual_leucine_zipper_kinase DLK . -RSB- .
20947510	0	dual_oxidase_1	123,137	DUOX1	139,144	dual oxidase 1	DUOX1	171608(Tax:6239)	171608(Tax:6239)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis_elegans dual_oxidase_1 -LRB- DUOX1 -RRB- peroxidase domain .
26597162	0	dual_oxidase_1	18,32	IL-33	59,64	dual oxidase 1	IL-33	53905	90865	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|secretion secretion|compound|END_ENTITY	Airway epithelial dual_oxidase_1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses .
18426362	0	dual_oxidase_2	44,58	DUOX2	60,65	dual oxidase 2	DUOX2	50506	50506	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel homozygous missense mutation of the dual_oxidase_2 -LRB- DUOX2 -RRB- gene in an adult patient with large goiter .
21565790	0	dual_oxidase_2	48,62	DUOX2	64,69	dual oxidase 2	DUOX2	50506	50506	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Identification and functional analysis of novel dual_oxidase_2 -LRB- DUOX2 -RRB- mutations in children with congenital_or_subclinical_hypothyroidism .
23457309	0	dual_oxidase_2	60,74	DUOX2	76,81	dual oxidase 2	DUOX2	50506	50506	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Congenital_hypothyroidism caused by a novel mutation of the dual_oxidase_2 -LRB- DUOX2 -RRB- gene .
17440044	0	dual_oxidase_2	103,117	Duox2	124,129	dual oxidase 2	Duox2	214593(Tax:10090)	214593(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Congenital_hypothyroidism , dwarfism , and hearing_impairment caused by a missense mutation in the mouse dual_oxidase_2 gene , Duox2 .
21321110	0	dual_oxidase_A2	130,145	DuoxA2	147,153	dual oxidase A2	DuoxA2	405753	405753	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Up-regulation and sustained activation of Stat1 are essential for interferon-gamma -LRB- IFN-gamma -RRB- - induced dual_oxidase_2 -LRB- Duox2 -RRB- and dual_oxidase_A2 -LRB- DuoxA2 -RRB- expression in human pancreatic_cancer cell lines .
18042646	0	dual_oxidase_maturation_factor_2	30,62	DUOXA2	64,70	dual oxidase maturation factor 2	DUOXA2	405753	405753	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Biallelic inactivation of the dual_oxidase_maturation_factor_2 -LRB- DUOXA2 -RRB- gene as a novel cause of congenital_hypothyroidism .
21317287	0	dual_specific_phosphatase-4	16,43	DUSP-4	45,51	dual specific phosphatase-4	DUSP-4	319520(Tax:10090)	319520(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion of the dual_specific_phosphatase-4 -LRB- DUSP-4 -RRB- gene reveals an essential non-redundant role for MAP kinase phosphatase-2 -LRB- MKP-2 -RRB- in proliferation and cell survival .
23642479	0	dual_specificity_tyrosine_phosphorylation-regulated	64,115	Dyrk	117,121	dual specificity tyrosine phosphorylation-regulated	Dyrk	1859	1859	Gene	Gene	kinases|amod|START_ENTITY kinases|appos|END_ENTITY	Small-molecule pyrimidine inhibitors of the cdc2-like -LRB- Clk -RRB- and dual_specificity_tyrosine_phosphorylation-regulated -LRB- Dyrk -RRB- kinases : development of chemical probe ML315 .
10924480	0	duchenne_muscular_dystrophy	57,84	Dmd	91,94	duchenne muscular dystrophy	Dmd	1756	1756	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Contrasting evolutionary histories of two introns of the duchenne_muscular_dystrophy gene , Dmd , in humans .
11756448	0	ducky	4,9	Cacna2d2	22,30	ducky	Cacna2d2	56808(Tax:10090)	56808(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	The ducky mutation in Cacna2d2 results in altered Purkinje cell morphology and is associated with the expression of a truncated alpha 2_delta-2 protein with abnormal function .
21088296	0	duffy_antigen_receptor_for_chemokines	84,121	DARC	123,127	duffy antigen receptor for chemokines	DARC	2532	2532	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activation state of alpha4beta1 integrin on sickle red blood cells is linked to the duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- expression .
18344456	0	dusp6	19,24	mkp3	26,30	dusp6	mkp3	67603(Tax:10090)	67603(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the dusp6 -LRB- mkp3 -RRB- gene with mouse brain weight and forebrain structure .
15326253	0	dynactin	39,47	DCTN1	49,54	dynactin	DCTN1	1639	1639	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Point mutations of the p150 subunit of dynactin -LRB- DCTN1 -RRB- gene in ALS .
17824900	0	dynactin	20,28	DCTN1	30,35	dynactin	DCTN1	1639	1639	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The p150 subunit of dynactin -LRB- DCTN1 -RRB- gene in multiple_sclerosis .
8744947	0	dynactin	38,46	p150Glued	0,9	dynactin	p150Glued	39536(Tax:7227)	39536(Tax:7227)	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex END_ENTITY|appos|subunit	p150Glued , the largest subunit of the dynactin complex , is nonessential in Neurospora but required for nuclear distribution .
16554302	0	dynactin_subunit_p62	32,52	ATP7B	76,81	dynactin subunit p62	ATP7B	51164	540	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Copper-dependent interaction of dynactin_subunit_p62 with the N terminus of ATP7B but not ATP7A .
24848261	0	dynamin-2	55,64	FGF21	0,5	dynamin-2	FGF21	1785	26291	Gene	Gene	pathway|amod|START_ENTITY promotes|nmod|pathway promotes|nsubj|END_ENTITY	FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway .
21411625	0	dynamin-2	46,55	Src	120,123	dynamin-2	Src	1785	6714	Gene	Gene	interaction|nmod|START_ENTITY regulates|nsubj|interaction regulates|nmod|END_ENTITY	A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src .
16049137	0	dynamin-2	19,28	VEGFR-2	32,39	dynamin-2	VEGFR-2	1785	3791	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Regulatory role of dynamin-2 in VEGFR-2 / KDR-mediated endothelial signaling .
18452187	0	dynamin-binding_protein	24,47	DNMBP	49,54	dynamin-binding protein	DNMBP	23268	23268	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Association analysis of dynamin-binding_protein -LRB- DNMBP -RRB- on chromosome 10q with late onset Alzheimer 's _ disease in a large caucasian UK sample .
25767741	0	dynamin-related_protein_1	30,55	Drp1	57,61	dynamin-related protein 1	Drp1	10059	10059	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction with the effector dynamin-related_protein_1 -LRB- Drp1 -RRB- is an ancient function of Rab32 subfamily proteins .
18845019	0	dynamin_1	87,96	Dnm1	103,107	dynamin 1	Dnm1	140694(Tax:10116)	140694(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nicotine modulates expression of miR-140 * , which targets the 3 ' - untranslated region of dynamin_1 gene -LRB- Dnm1 -RRB- .
17681954	0	dynamin_1	31,40	Sorting_nexin_9	0,15	dynamin 1	Sorting nexin 9	1759	51429	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sorting_nexin_9 interacts with dynamin_1 and N-WASP and coordinates synaptic_vesicle_endocytosis .
23467367	0	dynamin_1	36,45	cortactin	46,55	dynamin 1	cortactin	1759	2017	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Stabilization of actin bundles by a dynamin_1 / cortactin ring complex is necessary for growth cone filopodia .
21283621	0	dynamin_2	41,50	Ndel1	25,30	dynamin 2	Ndel1	1785	81565	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The cytoskeletal protein Ndel1 regulates dynamin_2 GTPase activity .
19075109	0	dynamitin	25,34	Alpha-E-catenin	0,15	dynamitin	Alpha-E-catenin	10540	1495	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic .
15845372	0	dynein_light_chain_2	18,38	p21-activated_kinase_1	68,90	dynein light chain 2	p21-activated kinase 1	140735	5058	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of dynein_light_chain_2 as an interaction partner of p21-activated_kinase_1 .
18677652	0	dysadherin	27,37	E-cadherin	106,116	dysadherin	E-cadherin	53827	999	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|END_ENTITY	Differential expression of dysadherin in papillary_thyroid_carcinoma and microcarcinoma : correlation with E-cadherin .
17577571	0	dysbindin	62,71	RNF151	0,6	dysbindin	RNF151	94245(Tax:10090)	67504(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RNF151 , a testis-specific_RING_finger_protein , interacts with dysbindin .
22580710	0	dysbindin-1	12,23	DTNBP1	4,10	dysbindin-1	DTNBP1	84062	84062	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	The DTNBP1 -LRB- dysbindin-1 -RRB- gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans .
16550931	0	dysferlin	30,39	dihydropyridine_receptor	69,93	dysferlin	dihydropyridine receptor	8291	779	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Intracellular localization of dysferlin and its association with the dihydropyridine_receptor .
23946118	0	dyskeratosis_congenita_1	66,90	DKC1	92,96	dyskeratosis congenita 1	DKC1	1736	1736	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Telomere phenotypes in females with heterozygous mutations in the dyskeratosis_congenita_1 -LRB- DKC1 -RRB- gene .
19621369	0	dystrobrevin-binding_protein_1	14,44	DTNBP1	46,52	dystrobrevin-binding protein 1	DTNBP1	84062	84062	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	The impact of dystrobrevin-binding_protein_1 -LRB- DTNBP1 -RRB- on neural correlates of episodic memory encoding and retrieval .
15066891	0	dystrobrevin_binding_protein	87,115	DTNBP1	122,128	dystrobrevin binding protein	DTNBP1	84062	84062	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin_binding_protein gene -LRB- DTNBP1 -RRB- .
12808430	0	dystrobrevin_binding_protein_1	48,78	DTNBP1	80,86	dystrobrevin binding protein 1	DTNBP1	84062	84062	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a high-risk haplotype for the dystrobrevin_binding_protein_1 -LRB- DTNBP1 -RRB- gene in the Irish study of high-density schizophrenia families .
15917270	0	dystrobrevin_binding_protein_1	18,48	DTNBP1	50,56	dystrobrevin binding protein 1	DTNBP1	84062	84062	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotypes at the dystrobrevin_binding_protein_1 -LRB- DTNBP1 -RRB- gene locus mediate risk for schizophrenia through reduced DTNBP1 expression .
17604607	0	dystrobrevin_binding_protein_1	30,60	DTNBP1	67,73	dystrobrevin binding protein 1	DTNBP1	84062	84062	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study between the dystrobrevin_binding_protein_1 gene -LRB- DTNBP1 -RRB- and schizophrenia : a meta-analysis .
19800201	0	dystrobrevin_binding_protein_1	4,34	DTNBP1	36,42	dystrobrevin binding protein 1	DTNBP1	84062	84062	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The dystrobrevin_binding_protein_1 -LRB- DTNBP1 -RRB- gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia -LRB- ICCSS -RRB- sample .
16611689	0	dystroglycan	11,23	DGN-1	24,29	dystroglycan	DGN-1	181283(Tax:6239)	181283(Tax:6239)	Gene	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	C. _ elegans dystroglycan DGN-1 functions in epithelia and neurons , but not muscle , and independently of dystrophin .
21289070	0	dystrophin	16,26	DOT1L	0,5	dystrophin	DOT1L	1756	84444	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	DOT1L regulates dystrophin expression and is critical for cardiac function .
8640231	0	dystrophin	40,50	DRP2	20,24	dystrophin	DRP2	1756	1821	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of DRP2 , a novel human dystrophin homologue .
7909532	0	dystrophin	38,48	STS	14,17	dystrophin	STS	1756	412	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	A polymorphic STS in intron 44 of the dystrophin gene .
10585405	0	dystrophin	56,66	Utrophin	0,8	dystrophin	Utrophin	1756	7402	Gene	Gene	activity|nmod|START_ENTITY lacks|dobj|activity lacks|nsubj|END_ENTITY	Utrophin lacks the rod domain actin binding activity of dystrophin .
10675780	0	dystrophin	31,41	Utrophin	0,8	dystrophin	Utrophin	24907(Tax:10116)	25600(Tax:10116)	Gene	Gene	precursor|nmod|START_ENTITY precursor|nsubj|END_ENTITY	Utrophin may be a precursor of dystrophin during skeletal muscle development .
8186707	0	dystrophin	38,48	Utrophin	0,8	dystrophin	Utrophin	1756	7402	Gene	Gene	replacement|nmod|START_ENTITY END_ENTITY|dep|replacement	Utrophin : a potential replacement for dystrophin ?
8866746	0	dystrophin	52,62	Utrophin	0,8	dystrophin	Utrophin	1756	7402	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Utrophin : a structural and functional comparison to dystrophin .
7890770	0	dystrophin	29,39	aciculin	15,23	dystrophin	aciculin	24907(Tax:10116)	226041(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of aciculin with dystrophin and utrophin .
9395493	0	dystrophin	39,49	beta-dystrobrevin	0,17	dystrophin	beta-dystrobrevin	1756	1838	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	beta-dystrobrevin , a new member of the dystrophin family .
21212803	0	dystrophin	17,27	miR-31	0,6	dystrophin	miR-31	1756	407035	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	miR-31 modulates dystrophin expression : new implications for Duchenne_muscular_dystrophy therapy .
8214011	0	dystrophin	16,26	myopathies	57,67	dystrophin	dystrophin	1756	1756	Gene	Gene	Localization|nmod|START_ENTITY Localization|nmod|END_ENTITY	Localization of dystrophin and beta-spectrin in vacuolar myopathies .
10369873	0	dystrophin	88,98	utrophin	41,49	dystrophin	utrophin	1756	7402	Gene	Gene	forms|nmod|START_ENTITY homologues|nmod|forms transcripts|acl:relcl|homologues transcripts|nmod|END_ENTITY	Up71 and up140 , two novel transcripts of utrophin that are homologues of short forms of dystrophin .
10423348	0	dystrophin	54,64	utrophin	6,14	dystrophin	utrophin	1756	7402	Gene	Gene	mutations|amod|START_ENTITY rescue|nmod|mutations rescue|nsubj|END_ENTITY	Could utrophin rescue the myocardium of patients with dystrophin gene mutations ?
11223239	0	dystrophin	4,14	utrophin	17,25	dystrophin	utrophin	42327(Tax:7227)	7402	Gene	Gene	START_ENTITY|parataxis|homologues homologues|nsubj|END_ENTITY	The dystrophin / utrophin homologues in Drosophila and in sea urchin .
8300622	0	dystrophin	37,47	utrophin	15,23	dystrophin	utrophin	1756	7402	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of utrophin and multiple dystrophin short forms with the mammalian M -LRB- r -RRB- 58,000 dystrophin-associated protein -LRB- syntrophin -RRB- .
8557116	0	dystrophin	27,37	utrophin	45,53	dystrophin	utrophin	100355731(Tax:9986)	100351667(Tax:9986)	Gene	Gene	Presence|nmod|START_ENTITY and/or|nsubj|Presence and/or|dobj|products products|compound|END_ENTITY	Presence of long and short dystrophin and/or utrophin products in Torpedo marmorata peripheral nerves .
11083927	0	dystrophin-related_protein_2	15,43	DRP2	45,49	dystrophin-related protein 2	DRP2	66027(Tax:10116)	66027(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of dystrophin-related_protein_2 -LRB- DRP2 -RRB- with postsynaptic densities in rat brain .
9245586	0	dystrophin-related_protein_2	18,46	Drp2	48,52	dystrophin-related protein 2	Drp2	13497(Tax:10090)	13497(Tax:10090)	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Expression of the dystrophin-related_protein_2 -LRB- Drp2 -RRB- transcript in the mouse .
15662113	0	e-cadherin	38,48	RTK	79,82	e-cadherin	RTK	999	5979	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	No one-way street : cross-talk between e-cadherin and receptor_tyrosine_kinase -LRB- RTK -RRB- signaling : a mechanism to regulate RTK activity .
25472142	0	e-cadherin	22,32	insulin-like_growth_factor-1	65,93	e-cadherin	insulin-like growth factor-1	999	3479	Gene	Gene	START_ENTITY|nmod|function function|nmod|END_ENTITY	93 the involvement of e-cadherin in thermoprotective function of insulin-like_growth_factor-1 in 4-cell hamster embryos .
23285691	0	e-cadherin	77,87	intercellular_adhesion_molecule-1	31,64	e-cadherin	intercellular adhesion molecule-1	999	3383	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Impact of celecoxib on soluble intercellular_adhesion_molecule-1 and soluble e-cadherin concentrations in human colon_cancer cell line cultures exposed to phytic_acid and TNF-alpha .
1659415	0	eEF-2	26,31	Ca2	42,45	eEF-2	Ca2	1938	760	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	Increased activity of the eEF-2 specific , Ca2 + and calmodulin_dependent_protein_kinase_III during the S-phase in Ehrlich ascites cells .
25423367	0	eEF1A1	33,39	SAMHD1	55,61	eEF1A1	SAMHD1	1915	25939	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The eukaryotic elongation factor eEF1A1 interacts with SAMHD1 .
25423367	0	eEF1A1	33,39	SAMHD1	55,61	eEF1A1	SAMHD1	1915	25939	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The eukaryotic elongation factor eEF1A1 interacts with SAMHD1 .
17130842	0	eEF1A2	0,6	Akt	17,20	eEF1A2	Akt	1917	207	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling , invasion and migration .
23739844	0	eEF1A2	0,6	Akt	118,121	eEF1A2	Akt	1917	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|upregulating upregulating|nmod|activation activation|compound|END_ENTITY	eEF1A2 promotes cell migration , invasion and metastasis in pancreatic_cancer by upregulating MMP-9 expression through Akt activation .
23466593	0	eEF2	27,31	AMPKalpha2	46,56	eEF2	AMPKalpha2	13629(Tax:10090)	108079(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart .
24648518	0	eEF2	88,92	C-terminal_Src_kinase	0,21	eEF2	C-terminal Src kinase	1938	1445	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	C-terminal_Src_kinase -LRB- Csk -RRB- - mediated phosphorylation of eukaryotic_elongation_factor_2 -LRB- eEF2 -RRB- promotes proteolytic cleavage and nuclear translocation of eEF2 .
23184662	0	eEF2	51,55	eEF2_kinase	123,134	eEF2	eEF2 kinase	1938	29904	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of eukaryotic_elongation_factor_2 -LRB- eEF2 -RRB- by cyclin_A-cyclin-dependent_kinase_2 regulates its inhibition by eEF2_kinase .
21822730	0	eEF2	34,38	eIF5A	0,5	eEF2	eIF5A	1938	1984	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	eIF5A interacts functionally with eEF2 .
24377563	0	eEF2	50,54	eukaryotic_elongation_factor_2	18,48	eEF2	eukaryotic elongation factor 2	1938	1938	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Clinical value of eukaryotic_elongation_factor_2 -LRB- eEF2 -RRB- in non-small cell lung_cancer patients .
23184662	0	eEF2_kinase	123,134	eEF2	51,55	eEF2 kinase	eEF2	29904	1938	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of eukaryotic_elongation_factor_2 -LRB- eEF2 -RRB- by cyclin_A-cyclin-dependent_kinase_2 regulates its inhibition by eEF2_kinase .
9811447	0	eFGF	133,137	Nck	50,53	eFGF	Nck	378586(Tax:8355)	399308(Tax:8355)	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|nsubj|END_ENTITY	Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus .
7925289	0	eFGF	0,4	Xbra	15,19	eFGF	Xbra	378586(Tax:8355)	432248(Tax:8355)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	eFGF regulates Xbra expression during Xenopus gastrulation .
26509856	0	eGFR	27,31	EGFR	54,58	eGFR	EGFR	1956	1956	Gene	Gene	START_ENTITY|nmod|FUNCTION FUNCTION|compound|END_ENTITY	COMBINING CREATININE-BASED eGFR WITH CYSTATIN_C-BASED EGFR TO BETTER ASSESS RENAL FUNCTION IN PATIENTS WITH DIABETES AND CHRONIC KIDNEY DISEASE 3A : IMPLICATIONS FOR DRUG SELECTION AND DOSAGE IN TYPE 2 DIABETES .
9428306	1	eIF-2_alpha	146,157	eIF-2_alpha	87,98	eIF-2 alpha	eIF-2 alpha	502531(Tax:10116)	502531(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	eIF-2_alpha kinase activity and role of initiation factors eIF-2_alpha and eIF-4E .
9428306	1	eIF-2_alpha	87,98	eIF-2_alpha	146,157	eIF-2 alpha	eIF-2 alpha	502531(Tax:10116)	502531(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	eIF-2_alpha kinase activity and role of initiation factors eIF-2_alpha and eIF-4E .
11526986	0	eIF-2alpha	55,65	iNOS	16,20	eIF-2alpha	iNOS	502531(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model .
8599971	0	eIF-4E	45,51	Erythropoietin	0,14	eIF-4E	Erythropoietin	13684(Tax:10090)	13856(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Erythropoietin stimulates phosphorylation of eIF-4E and identification of a 37-kD phosphoprotein that binds mRNA caps in erythroblasts .
1922056	0	eIF-4E	180,186	eIF-4F	213,219	eIF-4E	eIF-4F	1977	1977	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times , diminished translation rates , and reduced levels of both eIF-4E and the p220 component of eIF-4F .
2355012	0	eIF-4E	33,39	eIF-4F	74,80	eIF-4E	eIF-4F	1977	1977	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association of initiation factor eIF-4E in a cap binding protein complex -LRB- eIF-4F -RRB- is critical for and enhances phosphorylation by protein kinase C. Phosphorylation by protein kinase C of the mRNA_cap_binding_protein purified as part of a cap binding protein complex -LRB- eIF-4F -RRB- or as a single protein -LRB- eIF-4E -RRB- , has been examined .
14558943	0	eIF-4E	42,48	eukaryotic_initiation_factor-4E	9,40	eIF-4E	eukaryotic initiation factor-4E	1977	1977	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	-LSB- Role of eukaryotic_initiation_factor-4E -LRB- eIF-4E -RRB- in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon_adenocarcinoma cell line -RSB- .
1922056	0	eIF-4F	213,219	eIF-4E	180,186	eIF-4F	eIF-4E	1977	1977	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times , diminished translation rates , and reduced levels of both eIF-4E and the p220 component of eIF-4F .
2355012	0	eIF-4F	74,80	eIF-4E	33,39	eIF-4F	eIF-4E	1977	1977	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association of initiation factor eIF-4E in a cap binding protein complex -LRB- eIF-4F -RRB- is critical for and enhances phosphorylation by protein kinase C. Phosphorylation by protein kinase C of the mRNA_cap_binding_protein purified as part of a cap binding protein complex -LRB- eIF-4F -RRB- or as a single protein -LRB- eIF-4E -RRB- , has been examined .
9341116	0	eIF2B	16,21	PHAS-I	45,51	eIF2B	PHAS-I	117019(Tax:10116)	116636(Tax:10116)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells .
17526738	0	eIF2B	63,68	eukaryotic_initiation_factor_2B	30,61	eIF2B	eukaryotic initiation factor 2B	8894	8894	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Critical contacts between the eukaryotic_initiation_factor_2B -LRB- eIF2B -RRB- catalytic domain and both eIF2beta_and _ -2 gamma mediate guanine_nucleotide exchange .
17443820	0	eIF2B	56,61	eukaryotic_translation_initiation_factor_2B	11,54	eIF2B	eukaryotic translation initiation factor 2B	8893	8893	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for eukaryotic_translation_initiation_factor_2B -LRB- eIF2B -RRB- in taste memory consolidation and in thermal control establishment during the critical period for sensory development .
11311121	0	eIF2Bepsilon	67,79	DYRK	11,15	eIF2Bepsilon	DYRK	8893	1859	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated_protein_tau at Thr212 : potential role for DYRK as a glycogen synthase kinase 3-priming kinase .
22982228	0	eIF2a	83,88	COX-2	55,60	eIF2a	COX-2	1965	5743	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2a , p38-MAPK and NF-kB in advanced glycation end products stimulated human chondrocytes .
23000413	0	eIF2a	120,125	PERK	114,118	eIF2a	PERK	1965	9451	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Induction of REDD1 gene expression in the liver in response to endoplasmic reticulum stress is mediated through a PERK , eIF2a phosphorylation , ATF4-dependent cascade .
24889041	0	eIF2a	14,19	PERK	0,4	eIF2a	PERK	13665(Tax:10090)	13666(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	PERK mediates eIF2a phosphorylation responsible for BACE1 elevation , CREB_dysfunction and neurodegeneration in a mouse model of Alzheimer 's _ disease .
23392680	0	eIF2a	13,18	PKR	27,30	eIF2a	PKR	54318(Tax:10116)	54287(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Blocking the eIF2a kinase -LRB- PKR -RRB- enhances positive and negative forms of cortex-dependent taste memory .
23418347	0	eIF2a	25,30	PPP1R15	50,57	eIF2a	PPP1R15	32617(Tax:7227)	37820(Tax:7227)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Coordinate regulation of eIF2a phosphorylation by PPP1R15 and GCN2 is required during Drosophila development .
15355306	0	eIF2alpha	24,33	GCN2	0,4	eIF2alpha	GCN2	83939	440275	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation .
12767237	0	eIF2alpha	87,96	HRI	116,119	eIF2alpha	HRI	83939	27102	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI .
15355306	0	eIF2alpha	24,33	NF-kappaB	44,53	eIF2alpha	NF-kappaB	83939	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY activates|nsubj|phosphorylation activates|dobj|END_ENTITY	GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation .
17588536	0	eIF2alpha	67,76	Niban	51,56	eIF2alpha	Niban	83939	116496	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP 1 phosphorylation .
12605680	0	eIF2alpha	97,106	PERK	55,59	eIF2alpha	PERK	32617(Tax:7227)	9451	Gene	Gene	eukaryotic_initiation_factor_2alpha|appos|START_ENTITY eukaryotic_initiation_factor_2alpha|compound|END_ENTITY	Functional characterization of Drosophila_melanogaster PERK eukaryotic_initiation_factor_2alpha -LRB- eIF2alpha -RRB- kinase .
16000157	0	eIF2alpha	57,66	PERK	0,4	eIF2alpha	PERK	229317(Tax:10090)	13666(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY responsible|nmod|phosphorylation responsible|nsubj|END_ENTITY	PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain_ischemia .
16124869	0	eIF2alpha	6,15	PERK	0,4	eIF2alpha	PERK	83939	9451	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|appos|kinase	PERK -LRB- eIF2alpha kinase -RRB- is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis .
16176978	0	eIF2alpha	28,37	PERK	0,4	eIF2alpha	PERK	83939	9451	Gene	Gene	phosphorylation|amod|START_ENTITY contribute|nmod|phosphorylation contribute|nsubj|END_ENTITY	PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway .
17785458	0	eIF2alpha	4,13	PERK	22,26	eIF2alpha	PERK	83939	9451	Gene	Gene	kinases|nsubj|START_ENTITY kinases|ccomp|activate activate|nsubj|END_ENTITY	The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53 .
20072654	0	eIF2alpha	77,86	PERK	54,58	eIF2alpha	PERK	83939	9451	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Regulation of G -LRB- 1 -RRB- arrest and apoptosis in hypoxia by PERK and GCN2-mediated eIF2alpha phosphorylation .
11179981	0	eIF2alpha	182,191	PKR	92,95	eIF2alpha	PKR	83939	5610	Gene	Gene	2alpha|appos|START_ENTITY phosphorylation|nmod|2alpha regulating|dobj|phosphorylation important|advcl|regulating important|nsubj|sequences sequences|nmod|N-terminus N-terminus|nmod|kinase kinase|appos|END_ENTITY	Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase , PKR , are important for regulating phosphorylation of eukaryotic initiation factor 2alpha -LRB- eIF2alpha -RRB- .
16179258	0	eIF2alpha	38,47	PKR	84,87	eIF2alpha	PKR	83939	5610	Gene	Gene	recognition|nmod|START_ENTITY kinase|nsubj|recognition kinase|dobj|END_ENTITY	Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR .
16391235	0	eIF2alpha	52,61	PKR	141,144	eIF2alpha	PKR	83939	5610	Gene	Gene	phosphorylation|amod|START_ENTITY mRNA|nmod|phosphorylation resistance|nmod|mRNA resistance|dep|strategy strategy|acl|overcome overcome|dobj|effect effect|nmod|END_ENTITY	Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation : a strategy to overcome the antiviral effect of protein kinase PKR .
17715234	0	eIF2alpha	55,64	PKR	69,72	eIF2alpha	PKR	83939	5610	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation , which can be overcome by helper adenovirus_type_5 virus-associated RNA .
19587046	0	eIF2alpha	10,19	PKR	176,179	eIF2alpha	PKR	83939	19106(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY attenuates|nsubj|phosphorylation attenuates|dobj|replication replication|nmod|mutants mutants|nmod|fibroblasts fibroblasts|nmod|accumulation accumulation|nmod|ICP34 ICP34|compound|END_ENTITY	Increased eIF2alpha phosphorylation attenuates replication of herpes_simplex_virus_2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34 .5 .
9431994	0	eIF2alpha	89,98	PKR	213,216	eIF2alpha	PKR	83939	5610	Gene	Gene	subunit|nmod|START_ENTITY regions|nmod|subunit interact|nsubj|regions interact|nmod|domain domain|nmod|kinase kinase|appos|END_ENTITY	Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 -LRB- eIF2alpha -RRB- and the vaccinia_virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase -LRB- PKR -RRB- .
20631127	0	eIF2alpha	59,68	Protein_kinase_R	0,16	eIF2alpha	Protein kinase R	19106(Tax:10090)	19106(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY responsible|nmod|phosphorylation responsible|nsubj|END_ENTITY	Protein_kinase_R is responsible for the phosphorylation of eIF2alpha in rotavirus_infection .
17761498	0	eIF2alpha	142,151	heme-regulated_inhibitor	164,188	eIF2alpha	heme-regulated inhibitor	502531(Tax:10116)	27137(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Impaired dexamethasone-mediated induction of tryptophan_2 ,3 - dioxygenase in heme-deficient rat hepatocytes : translational control by a hepatic eIF2alpha kinase , the heme-regulated_inhibitor .
12706348	0	eIF2alpha	78,87	p67	113,116	eIF2alpha	p67	502531(Tax:10116)	64370(Tax:10116)	Gene	Gene	START_ENTITY|acl|associated associated|dobj|END_ENTITY	Mutation at the acidic residue-rich domain of eukaryotic initiation factor 2 -LRB- eIF2alpha -RRB- - associated glycoprotein p67 increases the protection of eIF2alpha phosphorylation during heat_shock .
25779044	0	eIF2b	21,26	DAP5	0,4	eIF2b	DAP5	8894	1982	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	DAP5 associates with eIF2b and eIF4AI to promote Internal Ribosome Entry Site driven translation .
18628297	0	eIF3	89,93	DDX3	6,10	eIF3	DDX3	8661	1654	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Human DDX3 functions in translation and interacts with the translation initiation factor eIF3 .
10488093	0	eIF3	219,223	Rpg1p	196,201	eIF3	Rpg1p	8661	852371(Tax:4932)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The Saccharomyces_cerevisiae HCR1 gene encoding a homologue of the p35 subunit of human translation initiation factor 3 -LRB- eIF3 -RRB- is a high copy suppressor of a temperature-sensitive mutation in the Rpg1p subunit of yeast eIF3 .
9973622	0	eIF3	120,124	eIF5	140,144	eIF3	eIF5	8661	1983	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 -LRB- eIF3 -RRB- : demonstration that eIF3 interacts with eIF5 in mammalian cells .
9973622	0	eIF3	94,98	eIF5	140,144	eIF3	eIF5	8661	1983	Gene	Gene	START_ENTITY|dep|demonstration demonstration|dep|interacts interacts|nmod|END_ENTITY	Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 -LRB- eIF3 -RRB- : demonstration that eIF3 interacts with eIF5 in mammalian cells .
10647903	0	eIF3	78,82	p40	29,32	eIF3	p40	8661	3578	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The EIF3S3 gene encoding the p40 subunit of the translation initiation factor eIF3 has eight exons and maps to the Langer-Giedion_syndrome chromosome region on 8q24 , but is not the TRPS1 gene .
9822659	0	eIF3	99,103	p44	39,42	eIF3	p44	8661	10561	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 .
23725059	0	eIF3f	39,44	hMSH4	15,20	eIF3f	hMSH4	8665	4438	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	MutS homologue hMSH4 : interaction with eIF3f and a role in NHEJ-mediated DSB repair .
20126553	0	eIF3f	35,40	mTOR	71,75	eIF3f	mTOR	66085(Tax:10090)	21977(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|END_ENTITY	The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse .
21113024	0	eIF4A	26,31	eIF4B	35,40	eIF4A	eIF4B	1974	1975	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of eIF4A by eIF4B and eIF4G .
16166382	0	eIF4A	40,45	eIF4G	67,72	eIF4A	eIF4G	1973	1981	Gene	Gene	enhancement|nmod|START_ENTITY basis|nmod|enhancement helicase|nsubj|basis helicase|nmod|END_ENTITY	Structural basis for the enhancement of eIF4A helicase activity by eIF4G .
16698552	0	eIF4A	99,104	eIF4G	74,79	eIF4A	eIF4G	1973	1981	Gene	Gene	binding|nmod|START_ENTITY support|xcomp|binding support|nsubj|domains domains|nmod|portion portion|nmod|END_ENTITY	Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1 .
19470518	0	eIF4A	61,66	eIF4G	115,120	eIF4A	eIF4G	1973	1981	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Domain-dependent interaction of eukaryotic initiation factor eIF4A for binding to middle and C-terminal domains of eIF4G .
21062831	0	eIF4A	54,59	eIF4G	0,5	eIF4A	eIF4G	1974	1981	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism .
21840318	0	eIF4A	64,69	eIF4G	85,90	eIF4A	eIF4G	1973	1981	Gene	Gene	unwinding|nmod|START_ENTITY coupled|nsubjpass|unwinding coupled|nmod|END_ENTITY	Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B .
23767688	0	eIF4A	64,69	eIF4G	146,151	eIF4A	eIF4G	1973	1981	Gene	Gene	correlates|amod|START_ENTITY helicase|dobj|correlates helicase|nmod|END_ENTITY	Molecular crowding enhanced ATPase activity of the RNA helicase eIF4A correlates with compaction of its quaternary structure and association with eIF4G .
9372926	0	eIF4A	115,120	eIF4G	51,56	eIF4A	eIF4G	1973	1981	Gene	Gene	possesses|nmod|START_ENTITY possesses|nsubj|eukaryotic_translation_initiation_factor_4G eukaryotic_translation_initiation_factor_4G|appos|END_ENTITY	Human eukaryotic_translation_initiation_factor_4G -LRB- eIF4G -RRB- possesses two separate and independent binding sites for eIF4A .
11418588	0	eIF4A	39,44	helicase	18,26	eIF4A	helicase	1973	164045	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modulation of the helicase activity of eIF4A by eIF4B , eIF4H , and eIF4F .
15541024	0	eIF4A1	86,92	eukaryotic_translation_initiation_factor_4A1	40,84	eIF4A1	eukaryotic translation initiation factor 4A1	1973	1973	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	All trans-retinoic_acid -LRB- ATRA -RRB- elevated eukaryotic_translation_initiation_factor_4A1 -LRB- eIF4A1 -RRB- mRNA in ATRA-responsive vitiliginous epidermis .
18719248	0	eIF4AI	21,27	eIF4B	54,59	eIF4AI	eIF4B	1973	1975	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|amod|END_ENTITY	Interactions between eIF4AI and its accessory factors eIF4B and eIF4H .
17375189	0	eIF4AIII	46,54	MLN51	0,5	eIF4AIII	MLN51	9775	22794	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	MLN51 stimulates the RNA-helicase activity of eIF4AIII .
17375189	0	eIF4AIII	46,54	RNA-helicase	21,33	eIF4AIII	RNA-helicase	9775	55308	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	MLN51 stimulates the RNA-helicase activity of eIF4AIII .
24205356	0	eIF4B	37,42	RSK	0,3	eIF4B	RSK	1975	6196	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	RSK activation of translation factor eIF4B drives abnormal increases of laminin y2 and MYC protein during neoplastic progression to squamous_cell_carcinoma .
21113024	0	eIF4B	35,40	eIF4A	26,31	eIF4B	eIF4A	1975	1974	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of eIF4A by eIF4B and eIF4G .
18719248	0	eIF4B	54,59	eIF4AI	21,27	eIF4B	eIF4AI	1975	1973	Gene	Gene	Interactions|amod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions between eIF4AI and its accessory factors eIF4B and eIF4H .
16825247	0	eIF4E	96,101	4E-BP1	66,72	eIF4E	4E-BP1	1977	1978	Gene	Gene	interaction|nmod|START_ENTITY Effect|nmod|interaction Effect|nmod|END_ENTITY	Effect of N-terminal region of eIF4E and Ser65-phosphorylation of 4E-BP1 on interaction between eIF4E and 4E-BP1 fragment peptide .
21661078	0	eIF4E	90,95	4E-BP2	114,120	eIF4E	4E-BP2	1977	1979	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms : crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP1 .
18706892	0	eIF4E	18,23	Akt	34,37	eIF4E	Akt	1977	207	Gene	Gene	survival|amod|START_ENTITY survival|compound|END_ENTITY	Ribavirin targets eIF4E dependent Akt survival signaling .
17684707	0	eIF4E	45,50	Eukaryotic_translation_initiation_factor_4E	0,43	eIF4E	Eukaryotic translation initiation factor 4E	13684(Tax:10090)	13684(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- expression in the brain tissue is induced by infusion of nerve_growth_factor into the mouse cisterna magnum : an in vivo study .
23974830	0	eIF4E	45,50	Eukaryotic_translation_initiation_factor_4E	0,43	eIF4E	Eukaryotic translation initiation factor 4E	1977	1977	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- expression is associated with breast_cancer_tumor phenotype and predicts survival after anthracycline chemotherapy treatment .
26151374	0	eIF4E	106,111	HSP27	17,22	eIF4E	HSP27	13684(Tax:10090)	15507(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Unphosphorylated HSP27 -LRB- HSPB1 -RRB- regulates the translation initiation process via a direct association with eIF4E in osteoblasts .
26151374	0	eIF4E	106,111	HSP27	17,22	eIF4E	HSP27	13684(Tax:10090)	15507(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Unphosphorylated HSP27 -LRB- HSPB1 -RRB- regulates the translation initiation process via a direct association with eIF4E in osteoblasts .
24814906	0	eIF4E	37,42	LMP1	0,4	eIF4E	LMP1	1977	9260	Gene	Gene	transcription|nmod|START_ENTITY stimulates|dobj|transcription stimulates|nsubj|END_ENTITY	LMP1 stimulates the transcription of eIF4E to promote the proliferation , migration and invasion of human nasopharyngeal_carcinoma .
26397141	0	eIF4E	56,61	LMP1	0,4	eIF4E	LMP1	1977	9260	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	LMP1 promotes nasal NK/T-cell _ lymphoma cell function by eIF4E via NF-kB pathway .
21047768	0	eIF4E	37,42	Mnk	0,3	eIF4E	Mnk	1977	538	Gene	Gene	phosphorylation|amod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Mnk mediates integrin a6b4-dependent eIF4E phosphorylation and translation of VEGF mRNA .
11112322	0	eIF4E	89,94	Protein_kinase_C-related_kinase_2	0,33	eIF4E	Protein kinase C-related kinase 2	1977	5586	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Protein_kinase_C-related_kinase_2 phosphorylates the protein synthesis initiation factor eIF4E in starfish oocytes .
20473326	0	eIF4E	114,119	SNF5	0,4	eIF4E	SNF5	13684(Tax:10090)	20587(Tax:10090)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	SNF5 , a core component of the SWI/SNF complex , is necessary for p53 expression and cell survival , in part through eIF4E .
21829374	0	eIF4E	34,39	Sxl	104,107	eIF4E	Sxl	45525(Tax:7227)	3772180(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The translation initiation factor eIF4E regulates the sex-specific expression of the master switch gene Sxl in Drosophila_melanogaster .
22509910	0	eIF4E	99,104	TRIM22	20,26	eIF4E	TRIM22	1977	10346	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G .
17203162	0	eIF4E	21,26	VEGF	79,83	eIF4E	VEGF	1977	7422	Gene	Gene	VEGF|compound|START_ENTITY levels|nmod|VEGF levels|nmod|eIF4E eIF4E|nmod|END_ENTITY	Expression levels of eIF4E , VEGF , and cyclin_D1 , and correlation of eIF4E with VEGF and cyclin_D1 in multi-tumor tissue microarray .
17203162	0	eIF4E	68,73	VEGF	28,32	eIF4E	VEGF	1977	7422	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Expression levels of eIF4E , VEGF , and cyclin_D1 , and correlation of eIF4E with VEGF and cyclin_D1 in multi-tumor tissue microarray .
19276085	0	eIF4E	105,110	eIF4F	122,127	eIF4E	eIF4F	1977	1977	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Structure of a viral cap-independent translation element that functions via high affinity binding to the eIF4E subunit of eIF4F .
26103369	0	eIF4E	109,114	eukaryotic_Translation_Initiation_Factor_4E	64,107	eIF4E	eukaryotic Translation Initiation Factor 4E	1977	1977	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	159 Stapled-peptides targeting the protein-binding interface of eukaryotic_Translation_Initiation_Factor_4E -LRB- eIF4E -RRB- protein .
16431125	0	eIF4E	91,96	eukaryotic_initiation_factor_4E	58,89	eIF4E	eukaryotic initiation factor 4E	13684(Tax:10090)	13684(Tax:10090)	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Posttranscriptional regulation of TNFalpha expression via eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- phosphorylation in mouse macrophages .
20823271	0	eIF4E	47,52	eukaryotic_initiation_factor_4E	14,45	eIF4E	eukaryotic initiation factor 4E	1977	1977	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Regulation of eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction .
9191527	0	eIF4E	51,56	eukaryotic_initiation_factor_4E	18,49	eIF4E	eukaryotic initiation factor 4E	1977	1977	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- in breast_carcinoma .
16024782	0	eIF4E	96,101	eukaryotic_translation_initiation_factor_4E	51,94	eIF4E	eukaryotic translation initiation factor 4E	1977	1977	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	hnRNP_K binds a core polypyrimidine element in the eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- promoter , and its regulation of eIF4E contributes to neoplastic transformation .
16283521	0	eIF4E	83,88	eukaryotic_translation_initiation_factor_4E	38,81	eIF4E	eukaryotic translation initiation factor 4E	1977	1977	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	Sodium_arsenite-induced inhibition of eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- results in cytotoxicity and cell death .
20064434	0	eIF4E	103,108	mTOR	30,34	eIF4E	mTOR	1977	21977(Tax:10090)	Gene	Gene	accumulation|nmod|START_ENTITY inhibitors|advcl|accumulation inhibitors|nsubj|screen screen|nmod|END_ENTITY	A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E .
21320304	0	eIF4E	41,46	mTOR	12,16	eIF4E	mTOR	1977	21977(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY inhibition|dep|activity inhibition|compound|END_ENTITY	Response to mTOR inhibition : activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast_cancer .
22216185	0	eIF4E	101,106	mTOR	37,41	eIF4E	mTOR	1977	21977(Tax:10090)	Gene	Gene	equilibrium|nmod|START_ENTITY depends|nmod|equilibrium depends|nsubj|Sensitivity Sensitivity|nmod|translation translation|nmod|inhibition inhibition|compound|END_ENTITY	Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1 .
24363449	0	eIF4E	57,62	mTOR	14,18	eIF4E	mTOR	1977	21977(Tax:10090)	Gene	Gene	amplification|nmod|START_ENTITY inhibitors|nmod|amplification inhibitors|nsubj|Adaptation Adaptation|nmod|kinase kinase|compound|END_ENTITY	Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation .
27050281	0	eIF4E	129,134	mTOR	86,90	eIF4E	mTOR	1977	21977(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	CGP57380 enhances efficacy of RAD001 in non-small_cell_lung_cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway .
17210710	0	eIF4E	184,189	mammalian_target_of_rapamycin	154,183	eIF4E	mammalian target of rapamycin	1977	2475	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Nitric_oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast_cancer cells : involvement of mammalian_target_of_rapamycin / eIF4E pathway .
16343815	0	eIF4E-Transporter	38,55	Clast4	0,6	eIF4E-Transporter	Clast4	56478	74203(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Clast4 , the murine homologue of human eIF4E-Transporter , is highly expressed in developing oocytes and post-translationally modified at meiotic maturation .
23667251	0	eIF4E1	131,137	Hypoxia-inducible_factor-1a	0,27	eIF4E1	Hypoxia-inducible factor-1a	1977	3091	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast_cancer cells under hypoxia conditions .
26370510	0	eIF4E2	25,31	Tristetraprolin	0,15	eIF4E2	Tristetraprolin	9470	7538	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Tristetraprolin recruits eIF4E2 to repress translation of ARE-containing mRNAs .
9619831	0	eIF4E_binding_protein_1	35,58	Gastrin	0,7	eIF4E binding protein 1	Gastrin	1978	2520	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Gastrin induces phosphorylation of eIF4E_binding_protein_1 and translation initiation of ornithine_decarboxylase mRNA .
22872150	0	eIF4F	38,43	DDX3	17,21	eIF4F	DDX3	1981	1654	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs .
19276085	0	eIF4F	122,127	eIF4E	105,110	eIF4F	eIF4E	1977	1977	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Structure of a viral cap-independent translation element that functions via high affinity binding to the eIF4E subunit of eIF4F .
16166382	0	eIF4G	67,72	eIF4A	40,45	eIF4G	eIF4A	1981	1973	Gene	Gene	helicase|nmod|START_ENTITY helicase|nsubj|basis basis|nmod|enhancement enhancement|nmod|END_ENTITY	Structural basis for the enhancement of eIF4A helicase activity by eIF4G .
16698552	0	eIF4G	74,79	eIF4A	99,104	eIF4G	eIF4A	1981	1973	Gene	Gene	portion|nmod|START_ENTITY domains|nmod|portion support|nsubj|domains support|xcomp|binding binding|nmod|END_ENTITY	Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1 .
19470518	0	eIF4G	115,120	eIF4A	61,66	eIF4G	eIF4A	1981	1973	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Domain-dependent interaction of eukaryotic initiation factor eIF4A for binding to middle and C-terminal domains of eIF4G .
21062831	0	eIF4G	0,5	eIF4A	54,59	eIF4G	eIF4A	1981	1974	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism .
21840318	0	eIF4G	85,90	eIF4A	64,69	eIF4G	eIF4A	1981	1973	Gene	Gene	coupled|nmod|START_ENTITY coupled|nsubjpass|unwinding unwinding|nmod|END_ENTITY	Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B .
23767688	0	eIF4G	146,151	eIF4A	64,69	eIF4G	eIF4A	1981	1973	Gene	Gene	helicase|nmod|START_ENTITY helicase|dobj|correlates correlates|amod|END_ENTITY	Molecular crowding enhanced ATPase activity of the RNA helicase eIF4A correlates with compaction of its quaternary structure and association with eIF4G .
9372926	0	eIF4G	51,56	eIF4A	115,120	eIF4G	eIF4A	1981	1973	Gene	Gene	eukaryotic_translation_initiation_factor_4G|appos|START_ENTITY possesses|nsubj|eukaryotic_translation_initiation_factor_4G possesses|nmod|END_ENTITY	Human eukaryotic_translation_initiation_factor_4G -LRB- eIF4G -RRB- possesses two separate and independent binding sites for eIF4A .
21576361	0	eIF4G1	110,116	Mnk1	128,132	eIF4G1	Mnk1	1981	8569	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4G1 -LRB- eIF4G1 -RRB- by protein_kinase_C -LCB- alpha -RCB- regulates eIF4G1 binding to Mnk1 .
21576361	0	eIF4G1	65,71	Mnk1	128,132	eIF4G1	Mnk1	1981	8569	Gene	Gene	Phosphorylation|nmod|START_ENTITY regulates|nsubj|Phosphorylation regulates|nmod|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4G1 -LRB- eIF4G1 -RRB- by protein_kinase_C -LCB- alpha -RCB- regulates eIF4G1 binding to Mnk1 .
9973622	0	eIF5	140,144	eIF3	120,124	eIF5	eIF3	1983	8661	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 -LRB- eIF3 -RRB- : demonstration that eIF3 interacts with eIF5 in mammalian cells .
9973622	0	eIF5	140,144	eIF3	94,98	eIF5	eIF3	1983	8661	Gene	Gene	interacts|nmod|START_ENTITY demonstration|dep|interacts END_ENTITY|dep|demonstration	Cloning and characterization of the p42 subunit of mammalian translation initiation factor 3 -LRB- eIF3 -RRB- : demonstration that eIF3 interacts with eIF5 in mammalian cells .
9395514	0	eIF5	68,72	eukaryotic_translation_initiation_factor_5	24,66	eIF5	eukaryotic translation initiation factor 5	1983	1983	Gene	Gene	interaction|appos|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of eukaryotic_translation_initiation_factor_5 -LRB- eIF5 -RRB- with the beta-subunit of eIF2 .
11861906	0	eIF5	62,66	mammalian_translation_initiation_factor_5	19,60	eIF5	mammalian translation initiation factor 5	1983	1983	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of mammalian_translation_initiation_factor_5 -LRB- eIF5 -RRB- in vitro and in vivo .
21822730	0	eIF5A	0,5	eEF2	34,38	eIF5A	eEF2	1984	1938	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	eIF5A interacts functionally with eEF2 .
19998337	0	eIF5A	98,103	eukaryotic_translation_initiation_factor_5A	53,96	eIF5A	eukaryotic translation initiation factor 5A	1984	1984	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance and therapeutic potential of eukaryotic_translation_initiation_factor_5A -LRB- eIF5A -RRB- in hepatocellular_carcinoma .
23867713	0	eNOS	47,51	DNA_methyltransferase_1	8,31	eNOS	DNA methyltransferase 1	4846	1786	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Role of DNA_methyltransferase_1 on the altered eNOS expression in human umbilical endothelium from intrauterine growth restricted fetuses .
14675775	0	eNOS	23,27	Growth_hormone	0,14	eNOS	Growth hormone	4846	2688	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Growth_hormone induces eNOS expression and nitric_oxide release in a cultured human endothelial cell line .
18925469	0	eNOS	18,22	HB-EGF	0,6	eNOS	HB-EGF	4846	1839	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	HB-EGF stimulates eNOS expression and nitric_oxide production and promotes eNOS dependent angiogenesis .
21063103	0	eNOS	40,44	Hsp90a	19,25	eNOS	Hsp90a	4846	3324	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	Opposite effect of Hsp90a and Hsp90b on eNOS ability to produce nitric_oxide or superoxide anion in human embryonic kidney cells .
20969943	0	eNOS	80,84	PI-3K	104,109	eNOS	PI-3K	24600(Tax:10116)	298947(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Chinese medicine Tongxinluo modulates vascular endothelial function by inducing eNOS expression via the PI-3K / Akt/HIF-dependent signaling pathway .
18220263	0	eNOS	86,90	PI3K	120,124	eNOS	PI3K	4846	5293	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Low-energy laser irradiation increases endothelial cell proliferation , migration , and eNOS gene expression possibly via PI3K signal pathway .
17229561	0	eNOS	26,30	PUFA	18,22	eNOS	PUFA	4846	9933	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells .
16981010	0	eNOS	24,28	TNF-alpha	0,9	eNOS	TNF-alpha	18127(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents .
12829187	0	eNOS	18,22	TNFalpha	42,50	eNOS	TNFalpha	4846	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Downregulation of eNOS mRNA expression by TNFalpha : identification and functional characterization of RNA-protein interactions in the 3 ` UTR .
17113146	0	eNOS	91,95	VEGF	60,64	eNOS	VEGF	443077(Tax:9940)	443103(Tax:9940)	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Reduction of maternal adrenal steroids results in increased VEGF protein without increased eNOS in the ovine placenta .
9837777	0	eNOS	29,33	VEGF-A	0,6	eNOS	VEGF-A	4846	7422	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 -LRB- KDR -RRB- .
24771066	0	eNOS	16,20	ZNF580	0,6	eNOS	ZNF580	4846	51157	Gene	Gene	START_ENTITY|nsubj|mediates mediates|compound|END_ENTITY	ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-b1 / ALK5/Smad2 pathway .
12799359	0	eNOS	105,109	eNOS	61,65	eNOS	eNOS	287024(Tax:9913)	287024(Tax:9913)	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- by HSP90 and Akt : calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex .
12799359	0	eNOS	61,65	eNOS	105,109	eNOS	eNOS	287024(Tax:9913)	287024(Tax:9913)	Gene	Gene	activation|nmod|START_ENTITY activation|dep|END_ENTITY	Synergistic activation of endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- by HSP90 and Akt : calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex .
16179591	0	eNOS	95,99	endothelial_NO_synthase	70,93	eNOS	endothelial NO synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Stoichiometric relationships between endothelial tetrahydrobiopterin , endothelial_NO_synthase -LRB- eNOS -RRB- activity , and eNOS coupling in vivo : insights from transgenic_mice with endothelial-targeted GTP_cyclohydrolase_1 and eNOS overexpression .
24938467	0	eNOS	54,58	endothelial_NO_synthase	24,47	eNOS	endothelial NO synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variants of the endothelial_NO_synthase gene -LRB- eNOS -RRB- may confer increased risk of sporadic congenital_heart_disease .
17145676	0	eNOS	57,61	endothelial_isoform	36,55	eNOS	endothelial isoform	4846	4846	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of endothelial_isoform -LRB- eNOS -RRB- in human cerebral arteries and the aorta .
12237402	0	eNOS	63,67	endothelial_nitric-oxide_synthase	28,61	eNOS	endothelial nitric-oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|END_ENTITY	Adenoviral gene transfer of endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- partially restores normal pulmonary arterial pressure in eNOS-deficient mice .
18252813	0	eNOS	109,113	endothelial_nitric-oxide_synthase	74,107	eNOS	endothelial nitric-oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- expression and preventing eNOS uncoupling .
10338373	0	eNOS	73,77	endothelial_nitric_oxide_synthase	38,71	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Expression and functional analysis of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in human placenta .
10444505	0	eNOS	52,56	endothelial_nitric_oxide_synthase	17,50	eNOS	endothelial nitric oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	transfer|appos|START_ENTITY transfer|nmod|END_ENTITY	Gene transfer of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in eNOS-deficient mice .
10967169	0	eNOS	58,62	endothelial_nitric_oxide_synthase	23,56	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	GnRH agonist decreases endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression in leiomyoma .
11401942	0	eNOS	124,128	endothelial_nitric_oxide_synthase	28,61	eNOS	endothelial nitric oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|expression expression|amod|END_ENTITY	Dysfunctional regulation of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression in response to exercise in mice lacking one eNOS gene .
11401942	0	eNOS	63,67	endothelial_nitric_oxide_synthase	28,61	eNOS	endothelial nitric oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Dysfunctional regulation of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression in response to exercise in mice lacking one eNOS gene .
16467782	0	eNOS	47,51	endothelial_nitric_oxide_synthase	12,45	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- genetic variants in European patients with intracranial_aneurysms .
17080303	0	eNOS	49,53	endothelial_nitric_oxide_synthase	14,47	eNOS	endothelial nitric oxide synthase	397557(Tax:9823)	397557(Tax:9823)	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- over-expressing piglets .
19240311	0	eNOS	92,96	endothelial_nitric_oxide_synthase	57,90	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lack of association between Glu -LRB- 298 -RRB- asp polymorphism of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene and coronary_artery_disease in Tamilian population .
19468830	0	eNOS	93,97	endothelial_nitric_oxide_synthase	58,91	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The 27-bp repeat polymorphism in intron 4 -LRB- 27 bp-VNTR -RRB- of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene is associated with albumin to creatinine ratio in Mexican Americans .
20467051	0	eNOS	79,83	endothelial_nitric_oxide_synthase	44,77	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphism -LRB- SNP -RRB- of the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene -LRB- Glu298Asp variant -RRB- in infertile men with asthenozoospermia .
21722303	0	eNOS	43,47	endothelial_nitric_oxide_synthase	8,41	eNOS	endothelial nitric oxide synthase	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in chronic stress-promoted tumour growth .
22017289	0	eNOS	51,55	endothelial_nitric_oxide_synthase	16,49	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Relationship of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene polymorphisms with diabetic_retinopathy in Caucasians with type 2 diabetes .
22134029	0	eNOS	64,68	endothelial_nitric_oxide_synthase	29,62	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Intron 4 polymorphism of the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene is associated with decreased NO production in a mercury-exposed population .
22311033	0	eNOS	83,87	endothelial_nitric_oxide_synthase	48,81	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The 4a/4a genotype of the VNTR polymorphism for endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene predicts risk for proliferative_diabetic_retinopathy in Slovenian patients -LRB- Caucasians -RRB- with type_2_diabetes_mellitus .
22561696	0	eNOS	67,71	endothelial_nitric_oxide_synthase	32,65	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of polymorphisms of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene with the risk of primary_open_angle_glaucoma in a Brazilian population .
23419608	0	eNOS	47,51	endothelial_nitric_oxide_synthase	12,45	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Variants in endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene in idiopathic infertile Brazilian men .
23947593	0	eNOS	111,115	endothelial_nitric_oxide_synthase	76,109	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Human metabolic transformation of quercetin blocks its capacity to decrease endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression and endothelin-1 secretion by human endothelial cells .
24706320	0	eNOS	47,51	endothelial_nitric_oxide_synthase	12,45	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in the pathogenesis of sinonasal polyps .
24976532	0	eNOS	74,78	endothelial_nitric_oxide_synthase	39,72	eNOS	endothelial nitric oxide synthase	4846	4846	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interplay between polymorphisms in the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene and metabolic_syndrome in determining the risk of ischemic_stroke in Koreans .
18242595	0	eNOS	62,66	hepatocyte_growth_factor	22,46	eNOS	hepatocyte growth factor	4846	3082	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Geldanamycin enhances hepatocyte_growth_factor stimulation of eNOS phosphorylation in endothelial cells .
9822444	0	eNOS	45,49	nNOS	8,12	eNOS	nNOS	18127(Tax:10090)	18125(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of nNOS in blood pressure regulation in eNOS null mutant mice .
15525466	0	eNOS	60,64	urotensin_II	15,27	eNOS	urotensin II	24600(Tax:10116)	29180(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of rat urotensin_II on coronary_flow and myocardial eNOS protein expression in isolated rat heart .
22319601	0	eNOS	72,76	urotensin_II	11,23	eNOS	urotensin II	4846	10911	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Endogenous urotensin_II selectively modulates erectile function through eNOS .
9195043	0	eRF1	33,37	Sup45p	39,45	eRF1	Sup45p	399462(Tax:8355)	852440(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the release factor eRF1 -LRB- Sup45p -RRB- gene of higher eukaryotes in yeast and mammalian tissues .
11788716	0	eRF1	59,63	eukaryotic_release_factor_1	30,57	eRF1	eukaryotic release factor 1	2107	2107	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Convergence and constraint in eukaryotic_release_factor_1 -LRB- eRF1 -RRB- domain 1 : the evolution of stop codon specificity .
24445282	0	eaf1	10,14	foxo3b	26,32	eaf1	foxo3b	415205(Tax:7955)	30296(Tax:7955)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis .
9858563	0	early_B-cell_factor	65,84	B29	4,7	early B-cell factor	B29	13591(Tax:10090)	15985(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	The B29 -LRB- immunoglobulin beta-chain -RRB- gene is a genetic target for early_B-cell_factor .
17374609	0	early_B-cell_factor	61,80	Cxcl12	4,10	early B-cell factor	Cxcl12	13591(Tax:10090)	20315(Tax:10090)	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	The Cxcl12 , periostin , and Ccl9 genes are direct targets for early_B-cell_factor in OP-9 stroma cells .
23174882	0	early_B-cell_factor_1	8,29	EBF1	31,35	early B-cell factor 1	EBF1	1879	1879	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of early_B-cell_factor_1 -LRB- EBF1 -RRB- in Hodgkin_lymphoma .
12077253	0	early_B_cell_factor	56,75	EBF	77,80	early B cell factor	EBF	1879	1879	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a promoter flanking the early_B_cell_factor -LRB- EBF -RRB- gene indicates roles for E-proteins and autoregulation in the control of EBF expression .
2351930	0	early_T_lymphocyte_activation_1	49,80	Eta-1	82,87	early T lymphocyte activation 1	Eta-1	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Definition of a specific interaction between the early_T_lymphocyte_activation_1 -LRB- Eta-1 -RRB- protein and murine macrophages in vitro and its effect upon macrophages in vivo .
2787378	0	early_T_lymphocyte_activation_1	41,72	Eta-1	74,79	early T lymphocyte activation 1	Eta-1	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural and functional studies of the early_T_lymphocyte_activation_1 -LRB- Eta-1 -RRB- gene .
11254538	0	early_growth-response_factor_1	25,55	tumor_necrosis_factor-alpha	66,93	early growth-response factor 1	tumor necrosis factor-alpha	13653(Tax:10090)	21926(Tax:10090)	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	The transcription factor early_growth-response_factor_1 modulates tumor_necrosis_factor-alpha , immunoglobulin E , and airway responsiveness in mice .
8466649	0	early_growth_response-1	54,77	Egr-1	79,84	early growth response-1	Egr-1	1958	1958	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Characterization of the DNA-binding properties of the early_growth_response-1 -LRB- Egr-1 -RRB- transcription factor : evidence for modulation by a redox mechanism .
12475986	0	early_growth_response-1	111,134	PPAR_gamma	157,167	early growth response-1	PPAR gamma	1958	5468	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Troglitazone , a peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR_gamma -RRB- ligand , selectively induces the early_growth_response-1 gene independently of PPAR_gamma .
21995436	0	early_growth_response-1	24,47	cysteine-rich_61	80,96	early growth response-1	cysteine-rich 61	1958	3491	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Cigarette smoke-induced early_growth_response-1 regulates the expression of the cysteine-rich_61 in human skin dermal fibroblasts .
8709978	0	early_growth_response-1	13,36	interleukin-1_beta	45,63	early growth response-1	interleukin-1 beta	1958	3553	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Induction of early_growth_response-1 gene by interleukin-1_beta and tumor_necrosis_factor-alpha in normal human bone marrow stromal an osteoblastic cells : regulation by a protein kinase C inhibitor .
23945289	0	early_growth_response-1	17,40	miR-20b	78,85	early growth response-1	miR-20b	1958	574032	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	Crucial role for early_growth_response-1 in the transcriptional regulation of miR-20b in breast_cancer .
17822668	0	early_growth_response-1	75,98	p73	34,37	early growth response-1	p73	1958	7161	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the p73 gene , a member of the p53 family , by early_growth_response-1 -LRB- Egr-1 -RRB- .
18303024	0	early_growth_response_1	30,53	CAR	17,20	early growth response 1	CAR	1958	9970	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	Nuclear receptor CAR requires early_growth_response_1 to activate the human cytochrome_P450_2B6 gene .
17916653	0	early_growth_response_1	116,139	EGR1	146,150	early growth response 1	EGR1	407125(Tax:9913)	407125(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prostaglandin_F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early_growth_response_1 gene -LRB- EGR1 -RRB- in the bovine corpus luteum .
23857582	0	early_growth_response_1	167,190	EGR1	192,196	early growth response 1	EGR1	1958	1958	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein -LRB- HnRNP -RRB- K genome-wide binding survey reveals its role in regulating 3 ' - end RNA processing and transcription termination at the early_growth_response_1 -LRB- EGR1 -RRB- gene through XRN2 exonuclease .
25028509	0	early_growth_response_1	147,170	EGR1	172,176	early growth response 1	EGR1	1958	1958	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A mitogen-activated_protein_kinase / extracellular_signal-regulated_kinase_kinase -LRB- MEK -RRB- - dependent transcriptional program controls activation of the early_growth_response_1 -LRB- EGR1 -RRB- gene during amino_acid limitation .
21725089	0	early_growth_response_1	26,49	Egr-1	51,56	early growth response 1	Egr-1	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Diurnal regulation of the early_growth_response_1 -LRB- Egr-1 -RRB- protein expression by hepatocyte nuclear factor 4alpha -LRB- HNF4alpha -RRB- and small heterodimer partner -LRB- SHP -RRB- cross-talk in liver fibrosis .
22542571	0	early_growth_response_1	48,71	Egr-1	73,78	early growth response 1	Egr-1	13653(Tax:10090)	13653(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Social isolation stress down-regulates cortical early_growth_response_1 -LRB- Egr-1 -RRB- expression in mice .
20448047	0	early_growth_response_1	31,54	HIF-1alpha	106,116	early growth response 1	HIF-1alpha	1958	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Placenta_growth_factor-induced early_growth_response_1 -LRB- Egr-1 -RRB- regulates hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- in endothelial cells .
12374773	0	early_growth_response_1	79,102	PLC_gamma_1	46,57	early growth response 1	PLC gamma 1	24330(Tax:10116)	25738(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene END_ENTITY|nmod|expression	Negative regulatory role of overexpression of PLC_gamma_1 in the expression of early_growth_response_1 gene in rat 3Y1 fibroblasts .
18303024	0	early_growth_response_1	30,53	cytochrome_P450_2B6	76,95	early growth response 1	cytochrome P450 2B6	1958	1555	Gene	Gene	START_ENTITY|xcomp|activate activate|dobj|gene gene|amod|END_ENTITY	Nuclear receptor CAR requires early_growth_response_1 to activate the human cytochrome_P450_2B6 gene .
24384380	0	early_growth_response_1	68,91	p21	108,111	early growth response 1	p21	1958	644914	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Shikonin induces cell cycle arrest in human gastric_cancer -LRB- AGS -RRB- by early_growth_response_1 -LRB- Egr1 -RRB- - mediated p21 gene expression .
7706752	0	early_growth_response_1	51,74	tumor_necrosis_factor	94,115	early growth response 1	tumor necrosis factor	1958	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of serine/threonine protein kinases and early_growth_response_1 gene expression by tumor_necrosis_factor in human myeloid_leukemia cells .
10369870	0	early_growth_response_2	44,67	EGR2	74,78	early growth response 2	EGR2	1959	1959	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional consequences of mutations in the early_growth_response_2 gene -LRB- EGR2 -RRB- correlate with severity of human myelinopathies .
26119399	0	early_growth_response_2	16,39	EGR2	41,45	early growth response 2	EGR2	1959	1959	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Resequencing of early_growth_response_2 -LRB- EGR2 -RRB- gene revealed a recurrent patient-specific mutation in schizophrenia .
9537424	0	early_growth_response_2	17,40	EGR2	42,46	early growth response 2	EGR2	1959	1959	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the early_growth_response_2 -LRB- EGR2 -RRB- gene are associated with hereditary myelinopathies .
22276163	0	early_growth_response_3	49,72	EGR3	74,78	early growth response 3	EGR3	1960	1960	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic evidence for the association between the early_growth_response_3 -LRB- EGR3 -RRB- gene and schizophrenia .
15078886	0	early_growth_response_factor-1	144,174	Egr-1	176,181	early growth response factor-1	Egr-1	1958	1958	Gene	Gene	accumulation|amod|START_ENTITY accumulation|compound|END_ENTITY	ERK1/2 associates with the c-Met-binding domain of growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- - associated_binder-1 -LRB- Gab1 -RRB- : role in ERK1/2 and early_growth_response_factor-1 -LRB- Egr-1 -RRB- nuclear accumulation .
16627584	0	early_growth_response_factor-1	60,90	c-jun	45,50	early growth response factor-1	c-jun	1958	3725	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Gonadotropin-releasing_hormone activation of c-jun , but not early_growth_response_factor-1 , stimulates transcription of a luteinizing hormone beta-subunit gene .
17556359	0	early_growth_response_factor-1	4,34	stem_cell_factor	50,66	early growth response factor-1	stem cell factor	13653(Tax:10090)	17311(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The early_growth_response_factor-1 is involved in stem_cell_factor -LRB- SCF -RRB- - induced interleukin_13 production by mast cells , but is dispensable for SCF-dependent mast cell growth .
21212994	0	early_growth_response_gene-1	14,42	TNF-a	0,5	early growth response gene-1	TNF-a	1958	7124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNF-a induces early_growth_response_gene-1 expression via ERK1/2 activation in endothelial cells .
17707346	0	early_growth_response_gene_1	14,42	ERK1/2	116,122	early growth response gene 1	ERK1/2	1958	5595;5594	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression Modulation|nmod|END_ENTITY	Modulation of early_growth_response_gene_1 and interleukin-8 expression by ribotoxin deoxynivalenol -LRB- vomitoxin -RRB- via ERK1/2 in human epithelial intestine_407 cells .
18190898	0	early_growth_response_gene_1	66,94	dopamine_beta-hydroxylase	18,43	early growth response gene 1	dopamine beta-hydroxylase	24330(Tax:10116)	25699(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of rat dopamine_beta-hydroxylase gene transcription by early_growth_response_gene_1 -LRB- Egr1 -RRB- .
8773576	0	early_growth_response_gene_1	12,40	egr-1	42,47	early growth response gene 1	egr-1	1958	1958	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of early_growth_response_gene_1 -LRB- egr-1 -RRB- in regulation of the immune response .
17014826	0	early_growth_response_gene_1	15,43	microsomal_prostaglandin_E_synthase_1	65,102	early growth response gene 1	microsomal prostaglandin E synthase 1	1958	9536	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Involvement of early_growth_response_gene_1 in the modulation of microsomal_prostaglandin_E_synthase_1 by epigallocatechin_gallate in A549 human pulmonary epithelial cells .
12456801	0	early_growth_response_protein_1	15,46	CREB	159,163	early growth response protein 1	CREB	1958	1385	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of early_growth_response_protein_1 -LRB- Egr-1 -RRB- , specificity_protein_1 -LRB- Sp1 -RRB- , and cyclic_adenosine_3 ' 5 ' - monophosphate response element binding protein -LRB- CREB -RRB- at a proximal response element is critical for gastrin-dependent activation of the chromogranin_A promoter .
23645673	0	early_mitotic_inhibitor_1	30,55	Emi1	57,61	early mitotic inhibitor 1	Emi1	26271	26271	Gene	Gene	depletion|amod|START_ENTITY depletion|appos|END_ENTITY	Selective enhancing effect of early_mitotic_inhibitor_1 -LRB- Emi1 -RRB- depletion on the sensitivity of doxorubicin or X-ray treatment in human cancer cells .
11410402	0	early_pregnancy_factor	56,78	EPF	80,83	early pregnancy factor	EPF	3336	3336	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Isolation , purification and partial characterization of early_pregnancy_factor -LRB- EPF -RRB- from sera of pregnant women .
2409862	0	early_pregnancy_factor	43,65	EPF	67,70	early pregnancy factor	EPF	3336	3336	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Use of a modified test system to determine early_pregnancy_factor -LRB- EPF -RRB- levels in patients with normal first trimester pregnancy and after therapeutic abortion .
2492450	0	easter	12,18	serine_protease	32,47	easter	serine protease	41858(Tax:7227)	43545(Tax:7227)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of easter , an apparent serine_protease , in organizing the dorsal-ventral pattern of the Drosophila embryo .
10215623	0	ebi	0,3	epidermal_growth_factor_receptor	14,46	ebi	epidermal growth factor receptor	33212(Tax:7227)	37455(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	ebi regulates epidermal_growth_factor_receptor signaling pathways in Drosophila .
10757764	0	ecdysone_receptor	15,32	EcR	34,37	ecdysone receptor	EcR	35540(Tax:7227)	35540(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Drosophila ecdysone_receptor -LRB- EcR -RRB- gene is required maternally for normal oogenesis .
10851134	0	ecdysone_receptor	64,81	EcR	83,86	ecdysone receptor	EcR	35540(Tax:7227)	35540(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A conditional rescue system reveals essential functions for the ecdysone_receptor -LRB- EcR -RRB- gene during molting and metamorphosis in Drosophila .
11210933	0	ecdysteroid_UDP-glucosyltransferase	24,59	egt	61,64	ecdysteroid UDP-glucosyltransferase	egt	5141101(Tax:31507)	5141101(Tax:31507)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the ecdysteroid_UDP-glucosyltransferase -LRB- egt -RRB- gene of Anticarsia_gemmatalis_nucleopolyhedrovirus .
7918100	0	eck	61,64	receptor-protein_tyrosine_kinase	22,54	eck	receptor-protein tyrosine kinase	13836(Tax:10090)	14257(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The expression of the receptor-protein_tyrosine_kinase gene , eck , is highly restricted during early mouse development .
9221928	0	ecto-apyrase	62,74	CD39	76,80	ecto-apyrase	CD39	953	953	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of brain ecto-apyrase : evidence for only one ecto-apyrase -LRB- CD39 -RRB- gene .
11691783	0	ectodermal-neural_cortex_1	21,47	ENC1	49,53	ectodermal-neural cortex 1	ENC1	8507	8507	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Up-regulation of the ectodermal-neural_cortex_1 -LRB- ENC1 -RRB- gene , a downstream target of the beta-catenin/T-cell factor complex , in colorectal_carcinomas .
9736768	0	ectodermal_dysplasia	15,35	EDA	42,45	ectodermal dysplasia	EDA	1896	1896	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The anhidrotic ectodermal_dysplasia gene -LRB- EDA -RRB- undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats .
17125505	0	ectodermal_dysplasia	49,69	EDAR	0,4	ectodermal dysplasia	EDAR	1896	10913	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	EDAR mutation in autosomal dominant hypohidrotic ectodermal_dysplasia in two Swedish families .
15757815	0	ectodermal_dysplasia	54,74	connexin	8,16	ectodermal dysplasia	connexin	1896	100128922	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Bigenic connexin mutations in a patient with hidrotic ectodermal_dysplasia .
23441037	0	ectodysplasin	36,49	Foxi3	14,19	ectodysplasin	Foxi3	13607(Tax:10090)	232077(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes .
21091672	0	ectodysplasin-A	33,48	EDA	50,53	ectodysplasin-A	EDA	1896	1896	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel missense mutation in the ectodysplasin-A -LRB- EDA -RRB- gene underlies X-linked_recessive_nonsyndromic_hypodontia .
20178980	0	ectonucleoside_triphosphate_diphosphohydrolase_1	49,97	CD39	99,103	ectonucleoside triphosphate diphosphohydrolase 1	CD39	953	953	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	cAMP/CREB-mediated transcriptional regulation of ectonucleoside_triphosphate_diphosphohydrolase_1 -LRB- CD39 -RRB- expression .
22402064	0	ectonucleotide_pyrophosphatase_phosphodiesterase_1	4,54	ENPP1	56,61	ectonucleotide pyrophosphatase phosphodiesterase 1	ENPP1	5167	5167	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	The ectonucleotide_pyrophosphatase_phosphodiesterase_1 -LRB- ENPP1 -RRB- K121Q polymorphism modulates the beneficial effect of weight loss on fasting glucose in non-diabetic individuals .
19638349	0	edn1	73,77	endothelin-1	54,66	edn1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aldosterone modulates steroid receptor binding to the endothelin-1 gene -LRB- edn1 -RRB- .
9245730	0	efp	125,128	estrogen-responsive_finger_protein	89,123	efp	estrogen-responsive finger protein	7706	7706	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple regulatory elements and binding proteins of the 5 ' - flanking region of the human estrogen-responsive_finger_protein -LRB- efp -RRB- gene .
9714786	0	efp	63,66	estrogen-responsive_finger_protein	27,61	efp	estrogen-responsive finger protein	217069(Tax:10090)	217069(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter analysis of mouse estrogen-responsive_finger_protein -LRB- efp -RRB- gene : mouse efp promoter contains an E-box that is also conserved in human .
19818618	0	eg5	22,25	Kif15	0,5	eg5	Kif15	3832	56992	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Kif15 cooperates with eg5 to promote bipolar spindle assembly .
20199686	0	egfr	20,24	CD44	40,44	egfr	CD44	1956	960	Gene	Gene	copies|compound|START_ENTITY regain|nmod|copies regain|nmod|+ +|compound|END_ENTITY	Selective regain of egfr gene copies in CD44 + / CD24 - / low breast_cancer cellular model MDA-MB-468 .
21559666	0	egfr	47,51	epidermal_growth-factor_receptor	13,45	egfr	epidermal growth-factor receptor	1956	1956	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	The value of epidermal_growth-factor_receptor -LRB- egfr -RRB- as a tumor-marker for human oral premalignant and malignant_lesions .
16428301	0	egg-derived_tyrosine_phosphatase	24,56	EDTP	15,19	egg-derived tyrosine phosphatase	EDTP	36959(Tax:7227)	36959(Tax:7227)	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of EDTP , an egg-derived_tyrosine_phosphatase , in the early development of Drosophila_melanogaster .
10849212	0	egr-1	23,28	NGFI-A	29,35	egr-1	NGFI-A	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Cyclical expression of egr-1 / NGFI-A in the rat anterior pituitary : a molecular signal for ovulation ?
2500119	0	egr-1	39,44	c-fos	32,37	egr-1	c-fos	1958	2353	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Indomethacin shifts the peak of c-fos , egr-1 , and c-myc gene expression in confluent fibroblasts induced by phorbol_myristate_acetate .
8773576	0	egr-1	42,47	early_growth_response_gene_1	12,40	egr-1	early growth response gene 1	1958	1958	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of early_growth_response_gene_1 -LRB- egr-1 -RRB- in regulation of the immune response .
10428039	0	egr-1	37,42	extracellular_signal-regulated_kinase	59,96	egr-1	extracellular signal-regulated kinase	13653(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Induction of an immediate early gene egr-1 by zinc through extracellular_signal-regulated_kinase activation in cortical culture : its role in zinc-induced neuronal_death .
15970222	0	egr-1	14,19	zif268	21,27	egr-1	zif268	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of egr-1 -LRB- zif268 -RRB- mRNA in select fear-related brain regions following exposure to a predator .
8625972	0	egr-2	141,146	krox_20	147,154	egr-2	krox 20	1959	1959	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	B cell early response gene expression coupled to B cell receptor , CD40 and interleukin-4_receptor co-stimulation : evidence for a role of the egr-2 / krox_20 transcription factor in B cell proliferation .
11210933	0	egt	61,64	ecdysteroid_UDP-glucosyltransferase	24,59	egt	ecdysteroid UDP-glucosyltransferase	5141101(Tax:31507)	5141101(Tax:31507)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the ecdysteroid_UDP-glucosyltransferase -LRB- egt -RRB- gene of Anticarsia_gemmatalis_nucleopolyhedrovirus .
17251388	0	ehd3	89,93	dendrin	80,87	ehd3	dendrin	57440(Tax:10090)	13199(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	ehd3	89,93	plekhh2	103,110	ehd3	plekhh2	57440(Tax:10090)	213556(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	ehd3	89,93	sh2d4a	95,101	ehd3	sh2d4a	57440(Tax:10090)	72281(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
10594026	0	ei24	0,4	p53	8,11	ei24	p53	9538	7157	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	ei24 , a p53 response gene involved in growth suppression and apoptosis .
3010492	0	elastase-like_proteinase	25,49	ELP	51,54	elastase-like proteinase	ELP	2516	2516	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of granulocyte elastase-like_proteinase -LRB- ELP -RRB- on platelet functions .
15615710	0	elastin	16,23	B-Myb	0,5	elastin	B-Myb	13717(Tax:10090)	17865(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	B-Myb represses elastin gene expression in aortic smooth muscle cells .
8117449	0	elastin	41,48	Basic_fibroblast_growth_factor	0,30	elastin	Basic fibroblast growth factor	25043(Tax:10116)	54250(Tax:10116)	Gene	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Basic_fibroblast_growth_factor decreases elastin production by neonatal rat lung fibroblasts .
16820942	0	elastin	29,36	ELN	43,46	elastin	ELN	2006	2006	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel mutations in the human elastin gene -LRB- ELN -RRB- causing isolated supravalvular_aortic_stenosis .
20926252	0	elastin	47,54	ELN	61,64	elastin	ELN	2006	2006	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence for heterozygous abnormalities of the elastin gene -LRB- ELN -RRB- affecting the quantity of vocal fold elastic fibers : a pilot study .
7625763	0	elastin	33,40	ELN	42,45	elastin	ELN	2006	2006	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular variation of the human elastin -LRB- ELN -RRB- gene in a normal human population .
7909531	0	elastin	35,42	ELN	49,52	elastin	ELN	2006	2006	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Two new polymorphisms in the human elastin gene -LRB- ELN -RRB- .
9873040	0	elastin	63,70	ELN	77,80	elastin	ELN	2006	2006	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cutis_laxa arising from frameshift mutations in exon 30 of the elastin gene -LRB- ELN -RRB- .
12882762	0	elastin	49,56	Heparin-binding_EGF-like_growth_factor	0,38	elastin	Heparin-binding EGF-like growth factor	25043(Tax:10116)	25433(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Heparin-binding_EGF-like_growth_factor regulates elastin and FGF-2 expression in pulmonary fibroblasts .
22339577	0	elastin	31,38	IL-1a	60,65	elastin	IL-1a	2006	3552	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Coenzyme Q -LRB- 10 -RRB- enhances dermal elastin expression , inhibits IL-1a production and melanin synthesis in vitro .
22236491	0	elastin	34,41	Insulin	0,7	elastin	Insulin	2006	3630	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Insulin induces production of new elastin in cultures of human aortic smooth muscle cells .
8092983	0	elastin	28,35	Interleukin_10	0,14	elastin	Interleukin 10	2006	3586	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Interleukin_10 up-regulates elastin gene expression in vivo and in vitro at the transcriptional level .
8618042	0	elastin	18,25	Lysozyme	0,8	elastin	Lysozyme	2006	4069	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Lysozyme binds to elastin and protects elastin from elastase-mediated degradation .
21539942	0	elastin	70,77	TGF-b1	91,97	elastin	TGF-b1	2006	7040	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Pulmonary fibroblasts from COPD patients show an impaired response of elastin synthesis to TGF-b1 .
9224204	0	elastin	17,24	TGF-beta	33,41	elastin	TGF-beta	2006	7040	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Stabilization of elastin mRNA by TGF-beta : initial characterization of signaling pathway .
9598840	0	elastin	71,78	TIMP-1	54,60	elastin	TIMP-1	25043(Tax:10116)	116510(Tax:10116)	Gene	Gene	accumulation|compound|START_ENTITY accumulation|compound|END_ENTITY	Metalloproteinase blockade by local overexpression of TIMP-1 increases elastin accumulation in rat carotid artery intima .
11804868	0	elastin	43,50	Transforming_growth_factor-beta	0,31	elastin	Transforming growth factor-beta	2006	7040	Gene	Gene	mRNA|compound|START_ENTITY stabilizes|dobj|mRNA stabilizes|nsubj|END_ENTITY	Transforming_growth_factor-beta stabilizes elastin mRNA by a pathway requiring active Smads , protein_kinase_C-delta , and p38 .
1573852	0	elastin	45,52	Transforming_growth_factor-beta	0,31	elastin	Transforming growth factor-beta	2006	7040	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Transforming_growth_factor-beta up-regulates elastin gene expression in human skin fibroblasts .
2167651	0	elastin	60,67	Transforming_growth_factor-beta_1	0,33	elastin	Transforming growth factor-beta 1	25043(Tax:10116)	59086(Tax:10116)	Gene	Gene	localizes|nmod|START_ENTITY localizes|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 specifically localizes in elastin during synovial_inflammation : an immunoelectron microscopic study .
1692217	0	elastin	27,34	epidermal_growth_factor	48,71	elastin	epidermal growth factor	396441(Tax:9031)	408035(Tax:9031)	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Preferential inhibition of elastin synthesis by epidermal_growth_factor in chick aortic smooth muscle cells .
10417681	0	elastin	122,129	fibrillin-1	131,142	elastin	fibrillin-1	2006	2200	Gene	Gene	component|amod|START_ENTITY component|amod|END_ENTITY	Degenerative processes of elastic fibers in sun-protected and sun-exposed skin : immunoelectron microscopic observation of elastin , fibrillin-1 , amyloid P component , lysozyme and alpha1-antitrypsin .
21540769	0	elastin	38,45	fibrillin-1	72,83	elastin	fibrillin-1	2006	2200	Gene	Gene	proteins|amod|START_ENTITY immunolocalization|nmod|proteins immunolocalization|amod|END_ENTITY	Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1 , LTBP-2 , and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc .
25586891	0	elastin	35,42	fibrillin-1	11,22	elastin	fibrillin-1	2006	2200	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Changes in fibrillin-1 expression , elastin expression and skin surface texture at sites of cultured epithelial autograft transplantation onto wounds from burn_scar_excision .
22324999	0	elastin	69,76	heat_shock_protein-47	46,67	elastin	heat shock protein-47	2006	871	Gene	Gene	components|amod|START_ENTITY components|amod|END_ENTITY	Beneficial regulation of fibrillar collagens , heat_shock_protein-47 , elastin fiber components , transforming_growth_factor-b1 , vascular_endothelial_growth_factor and oxidative stress effects by copper in dermal fibroblasts .
8454621	0	elastin	50,57	interleukin-1_beta	18,36	elastin	interleukin-1 beta	2006	3553	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Human recombinant interleukin-1_beta up-regulates elastin gene expression in dermal fibroblasts .
19473986	0	elastin	74,81	leptospira_immunoglobulin-like_proteins	20,59	elastin	leptospira immunoglobulin-like proteins	2006	3093	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|domains domains|nmod|END_ENTITY	Repeated domains of leptospira_immunoglobulin-like_proteins interact with elastin and tropoelastin .
10417681	0	elastin	122,129	lysozyme	165,173	elastin	lysozyme	2006	4069	Gene	Gene	component|amod|START_ENTITY observation|nmod|component observation|amod|END_ENTITY	Degenerative processes of elastic fibers in sun-protected and sun-exposed skin : immunoelectron microscopic observation of elastin , fibrillin-1 , amyloid P component , lysozyme and alpha1-antitrypsin .
20079884	0	elastin	36,43	semicarbazide-sensitive_amine_oxidase	53,90	elastin	semicarbazide-sensitive amine oxidase	2006	8639	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive_amine_oxidase in the context of its vascular-adhesion and tissue maturation functions .
10980128	0	elastin	121,128	tenascin-C	59,69	elastin	tenascin-C	25043(Tax:10116)	116640(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of matrix metalloproteinase activity attenuates tenascin-C production and calcification of implanted purified elastin in rats .
15081471	0	elastin	59,66	tenascin-C	45,55	elastin	tenascin-C	25043(Tax:10116)	116640(Tax:10116)	Gene	Gene	calcification|compound|START_ENTITY END_ENTITY|nmod|calcification	Involvement of matrix metalloproteinases and tenascin-C in elastin calcification .
17209135	0	elastin	14,21	transforming_growth_factor-beta	39,70	elastin	transforming growth factor-beta	2006	7040	Gene	Gene	Activation|nmod|START_ENTITY transcription|nsubj|Activation transcription|nmod|END_ENTITY	Activation of elastin transcription by transforming_growth_factor-beta in human lung fibroblasts .
20186130	0	elastin_microfibril_interfacer_1	25,57	EMILIN1	59,66	elastin microfibril interfacer 1	EMILIN1	11117	11117	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of the elastin_microfibril_interfacer_1 -LRB- EMILIN1 -RRB- gene in essential hypertension .
1903840	0	elav	27,31	ELAV	64,68	elav	ELAV	31000(Tax:7227)	31000(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|protein protein|compound|END_ENTITY	Organizational analysis of elav gene and functional analysis of ELAV protein of Drosophila_melanogaster and Drosophila_virilis .
17412732	0	electron-transferring-flavoprotein_dehydrogenase	76,124	ETFDH	126,131	electron-transferring-flavoprotein dehydrogenase	ETFDH	2110	2110	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The myopathic form of coenzyme_Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein_dehydrogenase -LRB- ETFDH -RRB- gene .
9568107	0	elongation_factor-1_delta	14,39	EF-1_delta	41,51	elongation factor-1 delta	EF-1 delta	1936	1936	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of elongation_factor-1_delta -LRB- EF-1_delta -RRB- expression by oncogenes in human epithelial cells .
3390175	0	elongation_factor_2	94,113	TPA	138,141	elongation factor 2	TPA	13629(Tax:10090)	112229(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Effect of tumor promoting phorbol_ester_TPA on epidermal protein synthesis : stimulation of an elongation_factor_2 phosphatase activity by TPA in vivo .
12960150	0	elongation_factor_G	55,74	ribosome_recycling_factor	26,51	elongation factor G	ribosome recycling factor	85476	92399	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of ribosome-bound ribosome_recycling_factor by elongation_factor_G .
18948280	0	elongation_factor_G	101,120	ribosome_recycling_factor	64,89	elongation factor G	ribosome recycling factor	85476	92399	Gene	Gene	RRF|appos|START_ENTITY RRF|appos|END_ENTITY	The role of GTP in transient splitting of 70S ribosomes by RRF -LRB- ribosome_recycling_factor -RRB- and EF-G -LRB- elongation_factor_G -RRB- .
9268331	0	elongation_factor_Tu	109,129	mitochondrial_elongation_factor_Ts	50,84	elongation factor Tu	mitochondrial elongation factor Ts	1915	10102	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Role of domains in Escherichia_coli and mammalian mitochondrial_elongation_factor_Ts in the interaction with elongation_factor_Tu .
18996918	0	elongator_protein_3	16,35	ELP3	37,41	elongator protein 3	ELP3	55140	55140	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of the elongator_protein_3 -LRB- ELP3 -RRB- gene are associated with motor neuron_degeneration .
10575222	0	elongin_A	61,70	Tceb3	77,82	elongin A	Tceb3	27224(Tax:10090)	27224(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structural organization and chromosome location of the mouse elongin_A gene -LRB- Tceb3 -RRB- .
8812452	0	embryonic_TEA_domain-containing_factor	64,102	ETF	104,107	embryonic TEA domain-containing factor	ETF	21677(Tax:10090)	21677(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structural organization and chromosomal assignment of the mouse embryonic_TEA_domain-containing_factor -LRB- ETF -RRB- gene .
23821546	0	embryonic_ectoderm_development	105,135	Eed	137,140	embryonic ectoderm development	Eed	13626(Tax:10090)	13626(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 -LRB- PRC2 -RRB- via targeting the mRNA of embryonic_ectoderm_development -LRB- Eed -RRB- gene in mouse embryonic stem cells .
26884329	0	embryonic_stem_cell-expressed_RAS	12,45	ERAS	47,51	embryonic stem cell-expressed RAS	ERAS	3266	3266	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of embryonic_stem_cell-expressed_RAS -LRB- ERAS -RRB- in the maintenance of quiescent hepatic stellate cells .
20811723	0	embryonic_stem_cell-expressed_Ras	89,122	ERas	124,128	embryonic stem cell-expressed Ras	ERas	3266	3266	Gene	Gene	signal|amod|START_ENTITY signal|appos|END_ENTITY	Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic_stem_cell-expressed_Ras -LRB- ERas -RRB- signal in neuroblastoma cells .
18230648	0	emerin	20,26	LUMA	0,4	emerin	LUMA	2010	79188	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LUMA interacts with emerin and influences its distribution at the inner nuclear membrane .
19727227	0	emerin	100,106	Mel18	75,80	emerin	Mel18	2010	7703	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Association of progerin-interactive partner proteins with lamina proteins : Mel18 is associated with emerin in HGPS .
24014020	0	emerin	52,58	barrier_to_autointegration_factor	70,103	emerin	barrier to autointegration factor	2010	8815	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	O-Linked b-N-acetylglucosamine -LRB- O-GlcNAc -RRB- regulates emerin binding to barrier_to_autointegration_factor -LRB- BAF -RRB- in a chromatin - and lamin B-enriched `` niche '' .
16858403	0	emerin	35,41	beta-catenin	52,64	emerin	beta-catenin	2010	1499	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus .
22570481	0	emerin	29,35	histone_deacetylase_3	54,75	emerin	histone deacetylase 3	2010	8841	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The nuclear envelope protein emerin binds directly to histone_deacetylase_3 -LRB- HDAC3 -RRB- and activates HDAC3 activity .
8707849	0	emo-1	0,5	Sec61p	32,38	emo-1	Sec61p	179510(Tax:6239)	178407(Tax:6239)	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	emo-1 , a Caenorhabditis_elegans Sec61p gamma homologue , is required for oocyte development and ovulation .
21566742	0	en-2	31,35	engrailed-2	18,29	en-2	engrailed-2	2020	2020	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Oncogenic role of engrailed-2 -LRB- en-2 -RRB- in prostate_cancer cell growth and survival .
14976239	0	endo-beta-mannanase	8,27	LeMAN5	43,49	endo-beta-mannanase	LeMAN5	543823(Tax:4081)	544170(Tax:4081)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	A novel endo-beta-mannanase gene in tomato LeMAN5 is associated with anther and pollen development .
25483913	0	endocan	108,115	adiponectin	75,86	endocan	adiponectin	11082	9370	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Increased expression of endocan in arthritic synovial tissues : Effects of adiponectin on the expression of endocan in fibroblast-like synoviocytes .
25483913	0	endocan	24,31	adiponectin	75,86	endocan	adiponectin	11082	9370	Gene	Gene	expression|nmod|START_ENTITY expression|dep|Effects Effects|nmod|END_ENTITY	Increased expression of endocan in arthritic synovial tissues : Effects of adiponectin on the expression of endocan in fibroblast-like synoviocytes .
24509328	0	endocan	58,65	endothelial_cell_specific_molecule-1	20,56	endocan	endothelial cell specific molecule-1	11082	11082	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Evaluation of serum endothelial_cell_specific_molecule-1 -LRB- endocan -RRB- levels as a biomarker in patients with pulmonary_thromboembolism .
26808694	0	endocan	44,51	endothelial_cell_specific_molecule-1	6,42	endocan	endothelial cell specific molecule-1	11082	11082	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum endothelial_cell_specific_molecule-1 -LRB- endocan -RRB- levels in patients with obstructive_sleep_apnea .
17683928	0	endocrine_gland-derived_vascular_endothelial_growth_factor	31,89	EG-VEGF	91,98	endocrine gland-derived vascular endothelial growth factor	EG-VEGF	84432	84432	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of endocrine_gland-derived_vascular_endothelial_growth_factor -LRB- EG-VEGF -RRB- in human pancreas and pancreatic_adenocarcinoma .
22833091	0	endoglin	120,128	TGF-b1	39,45	endoglin	TGF-b1	2022	7040	Gene	Gene	density|compound|START_ENTITY harbor|dobj|density prognosis|acl:relcl|harbor predicts|dobj|prognosis predicts|nsubj|expression expression|nmod|END_ENTITY	High immunohistochemical expression of TGF-b1 predicts a poor prognosis in cervical_cancer patients who harbor enriched endoglin microvessel density .
16907850	0	endoglin	49,57	TGF-beta1	61,70	endoglin	TGF-beta1	2022	7040	Gene	Gene	START_ENTITY|appos|co-receptor co-receptor|compound|END_ENTITY	Increased intrahepatic and circulating levels of endoglin , a TGF-beta1 co-receptor , in patients with chronic_hepatitis_C_virus_infection : relationship to histological and serum markers of hepatic_fibrosis .
20156938	0	endoglin	54,62	transforming_growth_factor-beta1	85,117	endoglin	transforming growth factor-beta1	497010(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY atorvastatin|nmod|expression effect|nmod|atorvastatin Mechanism|nmod|effect induced|nsubj|Mechanism induced|nmod|END_ENTITY	Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming_growth_factor-beta1 in cultured cardiac fibroblasts .
2534288	0	endonexin_II	10,22	ENX2	24,28	endonexin II	ENX2	308	308	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human endonexin_II -LRB- ENX2 -RRB- gene is located at 4q28 -- q32 .
15642122	0	endonuclease_G	168,182	caspase_9	129,138	endonuclease G	caspase 9	2021	842	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Saturated free fatty_acids and apoptosis in microvascular mesangial cells : palmitate activates pro-apoptotic signaling involving caspase_9 and mitochondrial release of endonuclease_G .
14622578	0	endophilin	29,39	Synaptojanin	0,12	endophilin	Synaptojanin	42265(Tax:7227)	37517(Tax:7227)	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating .
26966528	0	endoplasmic_reticulum_aminopeptidase-1	19,57	ERAP-1	59,65	endoplasmic reticulum aminopeptidase-1	ERAP-1	51752	51752	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association of endoplasmic_reticulum_aminopeptidase-1 -LRB- ERAP-1 -RRB- with Familial_Mediterranean_Fever -LRB- FMF -RRB- .
26966528	0	endoplasmic_reticulum_aminopeptidase-1	19,57	Familial_Mediterranean_Fever	72,100	endoplasmic reticulum aminopeptidase-1	Familial Mediterranean Fever	51752	4210	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	The association of endoplasmic_reticulum_aminopeptidase-1 -LRB- ERAP-1 -RRB- with Familial_Mediterranean_Fever -LRB- FMF -RRB- .
23988446	0	endoplasmic_reticulum_aminopeptidase_2	22,60	EpCAM	0,5	endoplasmic reticulum aminopeptidase 2	EpCAM	488897(Tax:9615)	481360(Tax:9615)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	EpCAM associates with endoplasmic_reticulum_aminopeptidase_2 -LRB- ERAP2 -RRB- in breast_cancer cells .
19274343	0	endoplasmic_reticulum_protein_chaperone_thio-oxidoreductase	21,80	gonadotropin-releasing_hormone_receptor	84,123	endoplasmic reticulum protein chaperone thio-oxidoreductase	gonadotropin-releasing hormone receptor	51060	2798	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Participation of the endoplasmic_reticulum_protein_chaperone_thio-oxidoreductase in gonadotropin-releasing_hormone_receptor expression at the plasma membrane .
27072616	0	endostatin	106,116	Biglycan	0,8	endostatin	Biglycan	12822(Tax:10090)	12111(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY altering|dobj|expression regulates|advcl|altering regulates|nsubj|END_ENTITY	Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin .
15148373	0	endostatin	58,68	E-selectin	0,10	endostatin	E-selectin	80781	6401	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	E-selectin is required for the antiangiogenic activity of endostatin .
15197351	0	endostatin	36,46	IL-8	61,65	endostatin	IL-8	80781	3576	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic_cancer .
21826988	0	endostatin	94,104	PKM2	72,76	endostatin	PKM2	12822(Tax:10090)	18746(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Antitumor effect by combination of shRNA interfering plasmid targeting PKM2 with recombinant endostatin -RSB- .
16106100	0	endostatin	15,25	TIMP2	72,77	endostatin	TIMP2	80781	7077	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of endostatin and tissue_inhibitor_of_metalloproteinases_2 -LRB- TIMP2 -RRB- serum levels with cardiovascular_involvement in systemic_sclerosis patients .
23726969	0	endostatin	54,64	Vascular_endothelial_growth_factor	0,34	endostatin	Vascular endothelial growth factor	12822(Tax:10090)	22339(Tax:10090)	Gene	Gene	therapy|amod|START_ENTITY biomarker|nmod|therapy END_ENTITY|nmod|biomarker	Vascular_endothelial_growth_factor as a biomarker for endostatin gene therapy .
26125720	0	endostatin	28,38	c-Myc	60,65	endostatin	c-Myc	80781	4609	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric_cancer cells .
12237301	0	endostatin	63,73	collagen_XVIII	48,62	endostatin	collagen XVIII	80781	80781	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Laminin modulates morphogenic properties of the collagen_XVIII endostatin domain .
15451191	0	endostatin	90,100	collagen_XVIII	22,36	endostatin	collagen XVIII	80781	80781	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Expression pattern of collagen_XVIII and its cleavage product , the angiogenesis inhibitor endostatin , at the fetal-maternal interface .
12390846	0	endostatin	23,33	interleukin-6	37,50	endostatin	interleukin-6	80781	3569	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	-LSB- Inhibitory effects of endostatin on interleukin-6 and interleukin-8 release by human umbilical vein endothelial cells -RSB- .
11156212	0	endostatin	6,16	vascular_endothelial_growth_factor	62,96	endostatin	vascular endothelial growth factor	80781	7422	Gene	Gene	levels|compound|START_ENTITY elevated|nsubj|levels elevated|nmod|levels levels|compound|END_ENTITY	Serum endostatin levels are elevated and correlate with serum vascular_endothelial_growth_factor levels in patients with stage IV_clear_cell_renal_cancer .
12354694	0	endostatin	26,36	vascular_endothelial_growth_factor	93,127	endostatin	vascular endothelial growth factor	12822(Tax:10090)	22339(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY associated|nsubjpass|effect associated|nmod|down-regulation down-regulation|nmod|expression expression|compound|END_ENTITY	The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular_endothelial_growth_factor expression in tumor cells .
15484319	0	endostatin	11,21	vascular_endothelial_growth_factor	39,73	endostatin	vascular endothelial growth factor	12822(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of endostatin on expression of vascular_endothelial_growth_factor and its receptors and neovascularization in colonic_carcinoma implanted in nude_mice .
16198337	0	endostatin	74,84	vascular_endothelial_growth_factor	18,52	endostatin	vascular endothelial growth factor	12822(Tax:10090)	22339(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of vascular_endothelial_growth_factor and integrinbeta3 by endostatin in a mouse model of retinal_neovascularization .
16379029	0	endostatin	6,16	vascular_endothelial_growth_factor	62,96	endostatin	vascular endothelial growth factor	80781	7422	Gene	Gene	levels|compound|START_ENTITY elevated|nsubj|levels elevated|nmod|levels levels|compound|END_ENTITY	Serum endostatin levels are elevated and correlate with serum vascular_endothelial_growth_factor levels in patients with pituitary_adenomas .
17181918	0	endostatin	69,79	vascular_endothelial_growth_factor	31,65	endostatin	vascular endothelial growth factor	80781	7422	Gene	Gene	ratio|acl|START_ENTITY ratio|nmod|END_ENTITY	Decreased ratio of circulatory vascular_endothelial_growth_factor to endostatin in patients with systemic_sclerosis -- association with pulmonary_involvement .
21672421	0	endostatin	75,85	vascular_endothelial_growth_factor	40,74	endostatin	vascular endothelial growth factor	80781	7422	Gene	Gene	Correlation|dep|START_ENTITY Correlation|nmod|ratio ratio|nmod|END_ENTITY	-LSB- Correlation between the ratio of serum vascular_endothelial_growth_factor / endostatin and childhood acute_leukemia -RSB- .
24648897	0	endostatin	29,39	vascular_endothelial_growth_factor	61,95	endostatin	vascular endothelial growth factor	80781	7422	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of recombinant human endostatin on the expression of vascular_endothelial_growth_factor in human gastric_cancer cell line MGC-803 .
1713680	0	endothelial-leukocyte_adhesion_molecule_1	14,55	ELAM-1	57,63	endothelial-leukocyte adhesion molecule 1	ELAM-1	6401	6401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Activation of endothelial-leukocyte_adhesion_molecule_1 -LRB- ELAM-1 -RRB- gene transcription .
1717513	0	endothelial-leukocyte_adhesion_molecule_1	8,49	ELAM-1	51,57	endothelial-leukocyte adhesion molecule 1	ELAM-1	25544(Tax:10116)	25544(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of endothelial-leukocyte_adhesion_molecule_1 -LRB- ELAM-1 -RRB- in neutrophil-mediated lung_injury in rats .
16179591	0	endothelial_NO_synthase	70,93	eNOS	95,99	endothelial NO synthase	eNOS	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Stoichiometric relationships between endothelial tetrahydrobiopterin , endothelial_NO_synthase -LRB- eNOS -RRB- activity , and eNOS coupling in vivo : insights from transgenic_mice with endothelial-targeted GTP_cyclohydrolase_1 and eNOS overexpression .
24938467	0	endothelial_NO_synthase	24,47	eNOS	54,58	endothelial NO synthase	eNOS	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants of the endothelial_NO_synthase gene -LRB- eNOS -RRB- may confer increased risk of sporadic congenital_heart_disease .
11301389	0	endothelial_PAS_domain_protein_1	66,98	vascular_endothelial_growth_factor	14,48	endothelial PAS domain protein 1	vascular endothelial growth factor	2034	7422	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor transcription by endothelial_PAS_domain_protein_1 -LRB- EPAS1 -RRB- and possible involvement of EPAS1 in the angiogenesis of renal_cell_carcinoma .
19080330	0	endothelial_PAS_domain_protein_1	10,42	vascular_endothelial_growth_factor	82,116	endothelial PAS domain protein 1	vascular endothelial growth factor	2034	7422	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of endothelial_PAS_domain_protein_1 and hypoxia_inducible_factor_1alpha on vascular_endothelial_growth_factor expression in human pancreatic_carcinoma .
14767275	0	endothelial_Per-Arnt-sim_domain_protein_1	27,68	hypoxia-inducible_factor-2alpha	69,100	endothelial Per-Arnt-sim domain protein 1	hypoxia-inducible factor-2alpha	2034	2034	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of endothelial_Per-Arnt-sim_domain_protein_1 / hypoxia-inducible_factor-2alpha expression in a subset of tumor associated macrophages in invasive_bladder_cancer .
1720810	0	endothelial_cell-leukocyte_adhesion_molecule_1	94,140	cutaneous_lymphocyte_antigen	4,32	endothelial cell-leukocyte adhesion molecule 1	cutaneous lymphocyte antigen	6401	6404	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	The cutaneous_lymphocyte_antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial_cell-leukocyte_adhesion_molecule_1 .
26906498	0	endothelial_cell-specific_molecule-1	10,46	ESM-1	48,53	Endothelial cell-specific molecule-1	ESM-1	11082	11082	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of endothelial_cell-specific_molecule-1 -LRB- ESM-1 -RRB- in overt hypothyroidisim .
16764824	0	endothelial_cell-specific_molecule_1	30,66	Hhex	0,4	endothelial cell-specific molecule 1	Hhex	11082	3087	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Hhex is a direct repressor of endothelial_cell-specific_molecule_1 -LRB- ESM-1 -RRB- .
10210777	0	endothelial_cell_adhesion_molecules	43,78	THP-1	28,33	endothelial cell adhesion molecules	THP-1	6401	2736	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Adhesion of human monocytic THP-1 cells to endothelial_cell_adhesion_molecules or extracellular matrix proteins via beta1_integrins regulates heparin_binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- expression .
1733667	0	endothelial_cell_growth_factor	52,82	ECGF1	84,89	endothelial cell growth factor	ECGF1	1890	1890	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regional localization of the human platelet-derived endothelial_cell_growth_factor -LRB- ECGF1 -RRB- gene to chromosome 22q13 .
8321913	0	endothelial_cell_growth_factor	65,95	interleukin-1	16,29	endothelial cell growth factor	interleukin-1	2246	3552	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Augmentation of interleukin-1 induced prostacyclin production by endothelial_cell_growth_factor : implications for chronic synovitis .
11246560	0	endothelial_cell_protein_C_receptor	45,80	EPCR	82,86	endothelial cell protein C receptor	EPCR	10544	10544	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Expression and anticoagulant function of the endothelial_cell_protein_C_receptor -LRB- EPCR -RRB- in cancer cell lines .
20383661	0	endothelial_cell_specific_molecule-1	18,54	ESM-1	56,61	endothelial cell specific molecule-1	ESM-1	11082	11082	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of endothelial_cell_specific_molecule-1 -LRB- ESM-1 -RRB- in gastric_cancer .
24509328	0	endothelial_cell_specific_molecule-1	20,56	endocan	58,65	endothelial cell specific molecule-1	endocan	11082	11082	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Evaluation of serum endothelial_cell_specific_molecule-1 -LRB- endocan -RRB- levels as a biomarker in patients with pulmonary_thromboembolism .
26808694	0	endothelial_cell_specific_molecule-1	6,42	endocan	44,51	endothelial cell specific molecule-1	endocan	11082	11082	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum endothelial_cell_specific_molecule-1 -LRB- endocan -RRB- levels in patients with obstructive_sleep_apnea .
17145676	0	endothelial_isoform	36,55	eNOS	57,61	endothelial isoform	eNOS	4846	4846	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of endothelial_isoform -LRB- eNOS -RRB- in human cerebral arteries and the aorta .
7514772	0	endothelial_leukocyte_adhesion_molecule-1	14,55	ELAM-1	57,63	endothelial leukocyte adhesion molecule-1	ELAM-1	6401	6401	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of endothelial_leukocyte_adhesion_molecule-1 -LRB- ELAM-1 -RRB- in chronic_inflammatory_demyelinating_polyneuropathy .
7685818	0	endothelial_leukocyte_adhesion_molecule-1	18,59	ELAM-1	61,67	endothelial leukocyte adhesion molecule-1	ELAM-1	6401	6401	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the endothelial_leukocyte_adhesion_molecule-1 -LRB- ELAM-1 -RRB- on endothelial cells in experimental gingivitis in humans .
1710341	0	endothelial_leukocyte_adhesion_molecule_1	84,125	ELAM-1	127,133	endothelial leukocyte adhesion molecule 1	ELAM-1	6401	6401	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial_leukocyte_adhesion_molecule_1 -LRB- ELAM-1 -RRB- gene transcription .
14984737	0	endothelial_lipase	59,77	LIPG	79,83	endothelial lipase	LIPG	9388	9388	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between single-nucleotide polymorphisms in the endothelial_lipase -LRB- LIPG -RRB- gene and high-density lipoprotein cholesterol levels .
10648830	0	endothelial_monocyte-activating_polypeptide_II	4,50	caspase-7	80,89	endothelial monocyte-activating polypeptide II	caspase-7	9255	840	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The endothelial_monocyte-activating_polypeptide_II -LRB- EMAP_II -RRB- is a substrate for caspase-7 .
9727019	0	endothelial_nitric-oxide_synthase	59,92	B2_receptor	42,53	endothelial nitric-oxide synthase	B2 receptor	4846	624	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Inhibitory interactions of the bradykinin B2_receptor with endothelial_nitric-oxide_synthase .
19946124	0	endothelial_nitric-oxide_synthase	28,61	Beta-actin	0,10	endothelial nitric-oxide synthase	Beta-actin	4846	728378	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Beta-actin association with endothelial_nitric-oxide_synthase modulates nitric_oxide and superoxide generation from the enzyme .
15640399	0	endothelial_nitric-oxide_synthase	66,99	Bradykinin	0,10	endothelial nitric-oxide synthase	Bradykinin	4846	3827	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	Bradykinin down-regulates , whereas arginine analogs up-regulates , endothelial_nitric-oxide_synthase expression in coronary endothelial cells .
20371606	0	endothelial_nitric-oxide_synthase	114,147	FGF2	56,60	endothelial nitric-oxide synthase	FGF2	4846	2247	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Activation of AP-1 transcription factors differentiates FGF2 and vascular_endothelial_growth_factor regulation of endothelial_nitric-oxide_synthase expression in placental artery endothelial cells .
14581470	0	endothelial_nitric-oxide_synthase	37,70	Tumor_necrosis_factor-alpha	0,27	endothelial nitric-oxide synthase	Tumor necrosis factor-alpha	287024(Tax:9913)	280943(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits endothelial_nitric-oxide_synthase gene promoter activity in bovine aortic endothelial cells .
16807357	0	endothelial_nitric-oxide_synthase	17,50	caveolin-1	83,93	endothelial nitric-oxide synthase	caveolin-1	4846	857	Gene	Gene	Translocation|nmod|START_ENTITY involves|nsubj|Translocation involves|nmod|END_ENTITY	Translocation of endothelial_nitric-oxide_synthase involves a ternary complex with caveolin-1 and NOSTRIN .
9712842	0	endothelial_nitric-oxide_synthase	59,92	caveolin-1	20,30	endothelial nitric-oxide synthase	caveolin-1	4846	857	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between caveolin-1 and the reductase domain of endothelial_nitric-oxide_synthase .
12237402	0	endothelial_nitric-oxide_synthase	28,61	eNOS	63,67	endothelial nitric-oxide synthase	eNOS	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	transfer|nmod|START_ENTITY transfer|appos|END_ENTITY	Adenoviral gene transfer of endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- partially restores normal pulmonary arterial pressure in eNOS-deficient mice .
18252813	0	endothelial_nitric-oxide_synthase	74,107	eNOS	109,113	endothelial nitric-oxide synthase	eNOS	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- expression and preventing eNOS uncoupling .
15333638	0	endothelial_nitric-oxide_synthase	14,47	p38_MAPK	55,63	endothelial nitric-oxide synthase	p38 MAPK	4846	1432	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of endothelial_nitric-oxide_synthase by the p38_MAPK in response to black tea polyphenols .
17919072	0	endothelial_nitric_oxide_synthase	36,69	AP-1	110,114	endothelial nitric oxide synthase	AP-1	287024(Tax:9913)	280831(Tax:9913)	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	Nordihydroguaiaretic_acid increases endothelial_nitric_oxide_synthase expression via the transcription factor AP-1 .
12895435	0	endothelial_nitric_oxide_synthase	39,72	Akt	118,121	endothelial nitric oxide synthase	Akt	4846	207	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Insulin enhances the expression of the endothelial_nitric_oxide_synthase in native endothelial cells : a dual role for Akt and AP-1 .
18192589	0	endothelial_nitric_oxide_synthase	32,65	Akt	81,84	endothelial nitric oxide synthase	Akt	443077(Tax:9940)	100294652(Tax:9940)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Protein kinase Cdelta regulates endothelial_nitric_oxide_synthase expression via Akt activation and nitric_oxide generation .
22301267	0	endothelial_nitric_oxide_synthase	34,67	C-reactive_protein	0,18	endothelial nitric oxide synthase	C-reactive protein	4846	1401	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	C-reactive_protein down-regulates endothelial_nitric_oxide_synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products .
20610538	0	endothelial_nitric_oxide_synthase	45,78	Caveolin_1	0,10	endothelial nitric oxide synthase	Caveolin 1	4846	857	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Caveolin_1 is required for the activation of endothelial_nitric_oxide_synthase in response to 17beta-estradiol .
10564099	0	endothelial_nitric_oxide_synthase	28,61	Endothelin-1	0,12	endothelial nitric oxide synthase	Endothelin-1	24600(Tax:10116)	24323(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Endothelin-1 stimulation of endothelial_nitric_oxide_synthase in the pathogenesis of hepatopulmonary_syndrome .
23836447	0	endothelial_nitric_oxide_synthase	23,56	Hsp90a	99,105	endothelial nitric oxide synthase	Hsp90a	4846	3324	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Humic_acid induces the endothelial_nitric_oxide_synthase phosphorylation at Ser1177 and Thr495_Via Hsp90a and Hsp90b upregulation in human umbilical vein endothelial cells .
12895435	0	endothelial_nitric_oxide_synthase	39,72	Insulin	0,7	endothelial nitric oxide synthase	Insulin	4846	3630	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Insulin enhances the expression of the endothelial_nitric_oxide_synthase in native endothelial cells : a dual role for Akt and AP-1 .
21788590	0	endothelial_nitric_oxide_synthase	58,91	NADPH_oxidase_4	0,15	endothelial nitric oxide synthase	NADPH oxidase 4	18127(Tax:10090)	50490(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	NADPH_oxidase_4 promotes endothelial angiogenesis through endothelial_nitric_oxide_synthase activation .
15492314	0	endothelial_nitric_oxide_synthase	43,76	NOS3	78,82	endothelial nitric oxide synthase	NOS3	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Cardiomyocyte-restricted overexpression of endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- attenuates beta-adrenergic stimulation and reinforces vagal inhibition of cardiac contraction .
18468205	0	endothelial_nitric_oxide_synthase	64,97	NOS3	99,103	endothelial nitric oxide synthase	NOS3	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of evidence for contribution of intron4a/b polymorphism of endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- gene to plasma nitric_oxide levels .
20367485	0	endothelial_nitric_oxide_synthase	17,50	NOS3	57,61	endothelial nitric oxide synthase	NOS3	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A variant of the endothelial_nitric_oxide_synthase gene -LRB- NOS3 -RRB- associated with AMS susceptibility is less common in the Quechua , a high altitude Native population .
7514568	0	endothelial_nitric_oxide_synthase	52,85	NOS3	87,91	endothelial nitric oxide synthase	NOS3	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and chromosomal localization of the human endothelial_nitric_oxide_synthase -LRB- NOS3 -RRB- gene .
9201025	0	endothelial_nitric_oxide_synthase	84,117	NOS_3	119,124	endothelial nitric oxide synthase	NOS 3	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial_nitric_oxide_synthase -LRB- NOS_3 -RRB- gene .
17545677	0	endothelial_nitric_oxide_synthase	35,68	Parathyroid_hormone	0,19	endothelial nitric oxide synthase	Parathyroid hormone	4846	5741	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates the endothelial_nitric_oxide_synthase through protein kinase A and C pathways .
11063722	0	endothelial_nitric_oxide_synthase	52,85	Replication_protein_A1	0,22	endothelial nitric oxide synthase	Replication protein A1	4846	6117	Gene	Gene	gene|amod|START_ENTITY transcription|nmod|gene reduces|dobj|transcription reduces|nsubj|END_ENTITY	Replication_protein_A1 reduces transcription of the endothelial_nitric_oxide_synthase gene containing a -786 T -- > C mutation associated with coronary_spastic_angina .
17785417	0	endothelial_nitric_oxide_synthase	71,104	SIRT1	0,5	endothelial nitric oxide synthase	SIRT1	18127(Tax:10090)	93759(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial_nitric_oxide_synthase .
16497987	0	endothelial_nitric_oxide_synthase	8,41	SREBP	63,68	endothelial nitric oxide synthase	SREBP	4846	7555	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of endothelial_nitric_oxide_synthase in the regulation of SREBP activation by oxidized phospholipids .
11912559	0	endothelial_nitric_oxide_synthase	65,98	Tumor_necrosis_factor-alpha	0,27	endothelial nitric oxide synthase	Tumor necrosis factor-alpha	4846	7124	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits insulin-induced increase in endothelial_nitric_oxide_synthase and reduces insulin_receptor content and phosphorylation in human aortic endothelial cells .
10066445	0	endothelial_nitric_oxide_synthase	49,82	VEGF	0,4	endothelial nitric oxide synthase	VEGF	4846	7422	Gene	Gene	KDR|advmod|START_ENTITY cells|compound|KDR translocation|nmod|cells induces|dobj|translocation induces|nsubj|END_ENTITY	VEGF induces nuclear translocation of Flk-1 / KDR , endothelial_nitric_oxide_synthase , and caveolin-1 in vascular endothelial cells .
16164642	0	endothelial_nitric_oxide_synthase	19,52	VEGF	0,4	endothelial nitric oxide synthase	VEGF	4846	7422	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	VEGF regulation of endothelial_nitric_oxide_synthase in glomerular endothelial cells .
17100655	0	endothelial_nitric_oxide_synthase	32,65	Von_Willebrand_factor	0,21	endothelial nitric oxide synthase	Von Willebrand factor	4846	7450	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Von_Willebrand_factor activates endothelial_nitric_oxide_synthase in blood platelets by a glycoprotein Ib-dependent mechanism .
10067868	0	endothelial_nitric_oxide_synthase	180,213	basic_fibroblast_growth_factor	95,125	endothelial nitric oxide synthase	basic fibroblast growth factor	4846	2247	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of the mitogen-activated protein kinase cascade is necessary but not sufficient for basic_fibroblast_growth_factor - and epidermal_growth_factor-stimulated expression of endothelial_nitric_oxide_synthase in ovine fetoplacental artery endothelial cells .
10338373	0	endothelial_nitric_oxide_synthase	38,71	eNOS	73,77	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression and functional analysis of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in human placenta .
10444505	0	endothelial_nitric_oxide_synthase	17,50	eNOS	52,56	endothelial nitric oxide synthase	eNOS	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	transfer|nmod|START_ENTITY transfer|appos|END_ENTITY	Gene transfer of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in eNOS-deficient mice .
10967169	0	endothelial_nitric_oxide_synthase	23,56	eNOS	58,62	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	GnRH agonist decreases endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression in leiomyoma .
11401942	0	endothelial_nitric_oxide_synthase	28,61	eNOS	124,128	endothelial nitric oxide synthase	eNOS	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression END_ENTITY|nsubj|regulation	Dysfunctional regulation of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression in response to exercise in mice lacking one eNOS gene .
11401942	0	endothelial_nitric_oxide_synthase	28,61	eNOS	63,67	endothelial nitric oxide synthase	eNOS	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dysfunctional regulation of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression in response to exercise in mice lacking one eNOS gene .
16467782	0	endothelial_nitric_oxide_synthase	12,45	eNOS	47,51	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- genetic variants in European patients with intracranial_aneurysms .
17080303	0	endothelial_nitric_oxide_synthase	14,47	eNOS	49,53	endothelial nitric oxide synthase	eNOS	397557(Tax:9823)	397557(Tax:9823)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- over-expressing piglets .
19240311	0	endothelial_nitric_oxide_synthase	57,90	eNOS	92,96	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between Glu -LRB- 298 -RRB- asp polymorphism of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene and coronary_artery_disease in Tamilian population .
19468830	0	endothelial_nitric_oxide_synthase	58,91	eNOS	93,97	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The 27-bp repeat polymorphism in intron 4 -LRB- 27 bp-VNTR -RRB- of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene is associated with albumin to creatinine ratio in Mexican Americans .
20467051	0	endothelial_nitric_oxide_synthase	44,77	eNOS	79,83	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphism -LRB- SNP -RRB- of the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene -LRB- Glu298Asp variant -RRB- in infertile men with asthenozoospermia .
21722303	0	endothelial_nitric_oxide_synthase	8,41	eNOS	43,47	endothelial nitric oxide synthase	eNOS	18127(Tax:10090)	18127(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in chronic stress-promoted tumour growth .
22017289	0	endothelial_nitric_oxide_synthase	16,49	eNOS	51,55	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relationship of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene polymorphisms with diabetic_retinopathy in Caucasians with type 2 diabetes .
22134029	0	endothelial_nitric_oxide_synthase	29,62	eNOS	64,68	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Intron 4 polymorphism of the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene is associated with decreased NO production in a mercury-exposed population .
22311033	0	endothelial_nitric_oxide_synthase	48,81	eNOS	83,87	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The 4a/4a genotype of the VNTR polymorphism for endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene predicts risk for proliferative_diabetic_retinopathy in Slovenian patients -LRB- Caucasians -RRB- with type_2_diabetes_mellitus .
22561696	0	endothelial_nitric_oxide_synthase	32,65	eNOS	67,71	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of polymorphisms of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene with the risk of primary_open_angle_glaucoma in a Brazilian population .
23419608	0	endothelial_nitric_oxide_synthase	12,45	eNOS	47,51	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants in endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene in idiopathic infertile Brazilian men .
23947593	0	endothelial_nitric_oxide_synthase	76,109	eNOS	111,115	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human metabolic transformation of quercetin blocks its capacity to decrease endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- expression and endothelin-1 secretion by human endothelial cells .
24706320	0	endothelial_nitric_oxide_synthase	12,45	eNOS	47,51	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- in the pathogenesis of sinonasal polyps .
24976532	0	endothelial_nitric_oxide_synthase	39,72	eNOS	74,78	endothelial nitric oxide synthase	eNOS	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interplay between polymorphisms in the endothelial_nitric_oxide_synthase -LRB- eNOS -RRB- gene and metabolic_syndrome in determining the risk of ischemic_stroke in Koreans .
20375905	0	endothelial_nitric_oxide_synthase	23,56	endothelial_nitric_oxide_synthase	82,115	endothelial nitric oxide synthase	endothelial nitric oxide synthase	4846	4846	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nsubj|activation	Interleukin-6 inhibits endothelial_nitric_oxide_synthase activation and increases endothelial_nitric_oxide_synthase binding to stabilized caveolin-1 in human vascular endothelial cells .
20375905	0	endothelial_nitric_oxide_synthase	82,115	endothelial_nitric_oxide_synthase	23,56	endothelial nitric oxide synthase	endothelial nitric oxide synthase	4846	4846	Gene	Gene	START_ENTITY|nsubj|activation activation|amod|END_ENTITY	Interleukin-6 inhibits endothelial_nitric_oxide_synthase activation and increases endothelial_nitric_oxide_synthase binding to stabilized caveolin-1 in human vascular endothelial cells .
11577023	0	endothelial_nitric_oxide_synthase	20,53	endothelin-converting_enzyme-1	70,100	endothelial nitric oxide synthase	endothelin-converting enzyme-1	4846	1889	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Thrombin suppresses endothelial_nitric_oxide_synthase and upregulates endothelin-converting_enzyme-1 expression by distinct pathways : role of Rho/ROCK and mitogen-activated protein kinase .
15967841	0	endothelial_nitric_oxide_synthase	19,52	heat_shock_protein_90	70,91	endothelial nitric oxide synthase	heat shock protein 90	18127(Tax:10090)	104434(Tax:10090)	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	Estradiol-mediated endothelial_nitric_oxide_synthase association with heat_shock_protein_90 requires adenosine_monophosphate-dependent protein kinase .
23478261	0	endothelial_nitric_oxide_synthase	30,63	hnRNP_E1	72,80	endothelial nitric oxide synthase	hnRNP E1	4846	5093	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Active stabilization of human endothelial_nitric_oxide_synthase mRNA by hnRNP_E1 protects against antisense RNA and microRNAs .
17093291	0	endothelial_or_lipoprotein_lipase	15,48	THP-1	52,57	endothelial or lipoprotein lipase	THP-1	4023	2736	Gene	Gene	START_ENTITY|nmod|macrophages macrophages|compound|END_ENTITY	Suppression of endothelial_or_lipoprotein_lipase in THP-1 macrophages attenuates proinflammatory cytokine secretion .
9804998	0	endothelial_protein_1	61,82	Edp1	84,88	endothelial protein 1	Edp1	21927(Tax:10090)	21927(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and chromosomal mapping of the TNF-alpha inducible endothelial_protein_1 -LRB- Edp1 -RRB- gene in the mouse .
17155946	0	endothelial_protein_C_receptor	10,40	ADAM17	111,117	endothelial protein C receptor	ADAM17	10544	6868	Gene	Gene	mediated|nsubjpass|START_ENTITY mediated|nmod|END_ENTITY	Regulated endothelial_protein_C_receptor shedding is mediated by tumor_necrosis_factor-alpha_converting_enzyme / ADAM17 .
11686350	0	endothelial_protein_C_receptor	24,54	EPCR	56,60	endothelial protein C receptor	EPCR	10544	10544	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A 23bp insertion in the endothelial_protein_C_receptor -LRB- EPCR -RRB- gene impairs EPCR function .
16113830	0	endothelial_protein_C_receptor	58,88	EPCR	90,94	endothelial protein C receptor	EPCR	10544	10544	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial_protein_C_receptor -LRB- EPCR -RRB- gene on the risk of venous_thromboembolism in carriers of factor_V_Leiden .
26620701	0	endothelial_protein_C_receptor	18,48	EPCR	50,54	endothelial protein C receptor	EPCR	10544	10544	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Haplotypes of the endothelial_protein_C_receptor -LRB- EPCR -RRB- gene are not associated with severe malaria in Tanzania .
12586611	0	endothelial_protein_C_receptor	92,122	protease_activated_receptor-1	141,170	endothelial protein C receptor	protease activated receptor-1	10544	2149	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Activated_protein_C alters cytosolic calcium flux in human brain endothelium via binding to endothelial_protein_C_receptor and activation of protease_activated_receptor-1 .
10458717	0	endothelin	24,34	Insulin	0,7	endothelin	Insulin	1906	3630	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Insulin stimulates both endothelin and nitric_oxide activity in the human forearm .
23441162	0	endothelin-1	25,37	ATF4	56,60	endothelin-1	ATF4	1906	468	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	HLA-B35 and dsRNA induce endothelin-1 via activation of ATF4 in human microvascular endothelial cells .
11159365	0	endothelin-1	102,114	Adrenomedullin	0,14	endothelin-1	Adrenomedullin	24323(Tax:10116)	25026(Tax:10116)	Gene	Gene	induced|advcl|START_ENTITY cells|acl|induced contraction|nmod|cells inhibits|dobj|contraction inhibits|nsubj|END_ENTITY	Adrenomedullin inhibits the contraction of cultured rat testicular peritubular myoid cells induced by endothelin-1 .
21824440	0	endothelin-1	94,106	Adrenomedullin	0,14	endothelin-1	Adrenomedullin	24323(Tax:10116)	25026(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Adrenomedullin in rat follicles and corpora lutea : expression , functions and interaction with endothelin-1 .
10029562	0	endothelin-1	40,52	Angiotensin_II	0,14	endothelin-1	Angiotensin II	1906	183	Gene	Gene	cells|amod|START_ENTITY release|nmod|cells increases|dobj|release increases|nsubj|END_ENTITY	Angiotensin_II increases the release of endothelin-1 from human cultured endothelial cells but does not regulate its circulating levels .
1333547	0	endothelin-1	26,38	Angiotensin_II	0,14	endothelin-1	Angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates endothelin-1 secretion in cultured rat mesangial cells .
14732213	0	endothelin-1	23,35	Angiotensin_II	0,14	endothelin-1	Angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces endothelin-1 gene expression via extracellular_signal-regulated_kinase pathway in rat aortic smooth muscle cells .
16188896	0	endothelin-1	64,76	Angiotensin_II	0,14	endothelin-1	Angiotensin II	13614(Tax:10090)	11606(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY arterioles|nmod|transgenic_mice arterioles|nsubj|sensitivity sensitivity|compound|END_ENTITY	Angiotensin_II sensitivity of afferent glomerular arterioles in endothelin-1 transgenic_mice .
16515797	0	endothelin-1	66,78	Angiotensin_II	0,14	endothelin-1	Angiotensin II	1906	183	Gene	Gene	activating|dep|START_ENTITY factor|amod|activating interaction|nmod|factor effect|dep|interaction effect|compound|END_ENTITY	Angiotensin_II effect on hydraulic permeability : interaction with endothelin-1 , nitric_oxide , and platelet activating factor .
16911918	0	endothelin-1	20,32	Angiotensin_II	144,158	endothelin-1	Angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY Effects|nmod|antagonists stimulated|nsubj|Effects stimulated|nmod|END_ENTITY	Effects of specific endothelin-1 receptor antagonists on proliferation and fibronectin production of glomerular mesangial cells stimulated with Angiotensin_II .
23625292	0	endothelin-1	23,35	Angiotensin_II	0,14	endothelin-1	Angiotensin II	1906	183	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces endothelin-1 expression in human hepatic stellate cells .
8488329	0	endothelin-1	27,39	Angiotensin_II	1,15	endothelin-1	Angiotensin II	1906	183	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	-LSB- Angiotensin_II stimulates endothelin-1 release from human endothelial cells -RSB- .
15838273	0	endothelin-1	13,25	CD40	90,94	endothelin-1	CD40	1906	958	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|nmod|action action|nmod|END_ENTITY	Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor -LRB- LOX-1 -RRB- .
8587360	0	endothelin-1	76,88	Ca2	0,3	endothelin-1	Ca2	24323(Tax:10116)	54231(Tax:10116)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Ca2 + and contractile responses of resistance vessels of WKY rats and SHR to endothelin-1 .
21681744	0	endothelin-1	16,28	Calpain-6	0,9	endothelin-1	Calpain-6	1906	827	Gene	Gene	factor|amod|START_ENTITY factor|nsubj|END_ENTITY	Calpain-6 is an endothelin-1 signaling dependent protective factor in chemoresistant osteosarcoma .
22546226	0	endothelin-1	68,80	Cathepsin_E	0,11	endothelin-1	Cathepsin E	13614(Tax:10090)	13034(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY induces|nmod|production induces|nsubj|END_ENTITY	Cathepsin_E induces itch-related response through the production of endothelin-1 in mice .
12391278	0	endothelin-1	48,60	Cyclooxygenase-2	0,16	endothelin-1	Cyclooxygenase-2	1906	5743	Gene	Gene	release|amod|START_ENTITY brake|nmod|release acts|nmod|brake acts|amod|END_ENTITY	Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells : implications for pulmonary_hypertension .
12193061	0	endothelin-1	137,149	EDN1	156,160	endothelin-1	EDN1	13614(Tax:10090)	13614(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin -2 gene -LRB- EDN2 -RRB- : comparison with the endothelin-1 gene -LRB- EDN1 -RRB- .
16521405	0	endothelin-1	40,52	EDN1	54,58	endothelin-1	EDN1	1906	1906	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	-LSB- Association of polymorphic variants in endothelin-1 -LRB- EDN1 -RRB- genes with the therapy of patients with cutaneous_T-cell_lymphomas -RSB- .
2018043	0	endothelin-1	66,78	EDN1	85,89	endothelin-1	EDN1	1906	1906	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal assignments of the human endothelin family genes : the endothelin-1 gene -LRB- EDN1 -RRB- to 6p23-p24 , the endothelin-2 gene -LRB- EDN2 -RRB- to 1p34 , and the endothelin-3 gene -LRB- EDN3 -RRB- to 20q13.2-q13 .3 .
8428511	0	endothelin-1	10,22	EDN1	29,33	endothelin-1	EDN1	1906	1906	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human endothelin-1 gene -LRB- EDN1 -RRB- encoding a peptide with potent vasoactive properties maps distal to HLA on chromosome arm 6p in close linkage to D6S89 .
12907462	0	endothelin-1	96,108	ERK1/2	35,41	endothelin-1	ERK1/2	24323(Tax:10116)	50689;116590	Gene	Gene	role|nmod|START_ENTITY dependence|dep|role dependence|nmod|END_ENTITY	Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch : role of endothelin-1 .
16756989	0	endothelin-1	138,150	ERK1/2	82,88	endothelin-1	ERK1/2	24323(Tax:10116)	50689;116590	Gene	Gene	cascade|nmod|START_ENTITY cascade|csubj|Using Using|xcomp|dissect dissect|dobj|role role|nmod|2 2|appos|END_ENTITY	Using U0126 to dissect the role of the extracellular_signal-regulated_kinase_1 / 2 -LRB- ERK1/2 -RRB- cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes .
20368814	0	endothelin-1	104,116	ERK1/2	0,6	endothelin-1	ERK1/2	24323(Tax:10116)	50689;116590	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced regulating|nmod|expression signaling|advcl|regulating RhoA|acl|signaling dominates|nmod|RhoA dominates|nsubj|signaling signaling|compound|END_ENTITY	ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes .
20628425	0	endothelin-1	16,28	ERK5	56,60	endothelin-1	ERK5	24323(Tax:10116)	114509(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Glucose-induced endothelin-1 expression is regulated by ERK5 in the endothelial cells and retina of diabetic rats .
10190051	0	endothelin-1	44,56	ET-1	58,62	endothelin-1	ET-1	100726197	100726197	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Antigen-induced elevation of immunoreactive endothelin-1 -LRB- ET-1 -RRB- levels in ovalbumin-sensitized guinea_pig airway tissue .
11210078	0	endothelin-1	87,99	ET-1	101,105	endothelin-1	ET-1	1906	1906	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interactions of lymphotoxin alpha -LRB- TNF-beta -RRB- , angiotensin-converting_enzyme -LRB- ACE -RRB- , and endothelin-1 -LRB- ET-1 -RRB- gene polymorphisms in adult_periodontitis .
12674218	0	endothelin-1	32,44	ET-1	46,50	endothelin-1	ET-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Negative chronotropic effect of endothelin-1 -LRB- ET-1 -RRB- in the cardiac pacemaker tissue .
14575417	0	endothelin-1	29,41	ET-1	43,47	endothelin-1	ET-1	1906	1906	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of endothelin-1 -LRB- ET-1 -RRB- in human acute renal allograft rejection .
1964364	0	endothelin-1	51,63	ET-1	65,69	endothelin-1	ET-1	1906	1906	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Contractile effects and receptor distributions for endothelin-1 -LRB- ET-1 -RRB- in human and animal airways .
9222086	0	endothelin-1	11,23	ET-1	25,29	endothelin-1	ET-1	1906	1906	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of endothelin-1 -LRB- ET-1 -RRB- on ocular hemodynamics .
8019752	0	endothelin-1	56,68	ETA	0,3	endothelin-1	ETA	24323(Tax:10116)	24326(Tax:10116)	Gene	Gene	receptor-mediated|nmod|START_ENTITY receptor-mediated|nsubj|END_ENTITY	ETA receptor-mediated responses to endothelin-1 and big endothelin-1 in the rat kidney .
1653767	0	endothelin-1	23,35	Endothelin-3	0,12	endothelin-1	Endothelin-3	1906	1908	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Endothelin-3 regulates endothelin-1 production in cultured human endothelial cells .
1918021	0	endothelin-1	14,26	Fos	46,49	endothelin-1	Fos	1906	2353	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of endothelin-1 gene expression by Fos and Jun. .
11156886	0	endothelin-1	55,67	GATA4	28,33	endothelin-1	GATA4	24323(Tax:10116)	54254(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Pressure overload increases GATA4 binding activity via endothelin-1 .
10374451	0	endothelin-1	25,37	GM-CSF	15,21	endothelin-1	GM-CSF	1906	1437	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The effect of GM-CSF on endothelin-1 and endothelin_converting_enzyme gene expression in human airway smooth muscle cells with or without theophylline incubation -RSB- .
18809573	0	endothelin-1	51,63	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	endothelin-1	Glyceraldehyde-3-phosphate dehydrogenase	1906	2597	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase regulates endothelin-1 expression by a novel , redox-sensitive mechanism involving mRNA stability .
24915580	0	endothelin-1	32,44	Grainyhead-like_3	0,17	endothelin-1	Grainyhead-like 3	1906	57822	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Grainyhead-like_3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton .
9724269	0	endothelin-1	13,25	IL-2	39,43	endothelin-1	IL-2	24323(Tax:10116)	116562(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Induction of endothelin-1 synthesis by IL-2 and its modulation of rat intestinal epithelial cell growth .
7883838	0	endothelin-1	19,31	Insulin	0,7	endothelin-1	Insulin	1906	3630	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Insulin stimulates endothelin-1 secretion from human endothelial cells and modulates its circulating levels in vivo .
8345807	0	endothelin-1	30,42	Insulin	0,7	endothelin-1	Insulin	1906	3630	Gene	Gene	levels|amod|START_ENTITY circulating|dobj|levels modulates|xcomp|circulating modulates|nsubj|END_ENTITY	Insulin modulates circulating endothelin-1 levels in humans .
19074677	0	endothelin-1	48,60	Interleukin-10	0,14	endothelin-1	Interleukin-10	13614(Tax:10090)	16153(Tax:10090)	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway .
24979306	0	endothelin-1	32,44	Klotho	15,21	endothelin-1	Klotho	24323(Tax:10116)	83504(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Antiaging gene Klotho regulates endothelin-1 levels and endothelin receptor subtype B expression in kidneys of spontaneously hypertensive rats .
11934840	0	endothelin-1	15,27	Leptin	0,6	endothelin-1	Leptin	1906	3952	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Leptin induces endothelin-1 in endothelial cells in vitro .
17678888	0	endothelin-1	18,30	Leptin	0,6	endothelin-1	Leptin	24323(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal_growth_factor_receptor transactivation in rat aortic smooth muscle cells .
23372172	0	endothelin-1	23,35	Leptin	0,6	endothelin-1	Leptin	1906	3952	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Leptin stimulates both endothelin-1 and nitric_oxide activity in lean subjects but not in patients with obesity-related metabolic_syndrome .
9722548	0	endothelin-1	53,65	NF-kappaB	8,17	endothelin-1	NF-kappaB	1906	4790	Gene	Gene	effect|nmod|START_ENTITY Role|nmod|effect Role|nmod|END_ENTITY	Role of NF-kappaB in the antiproliferative effect of endothelin-1 and tumor_necrosis_factor-alpha in human hepatic_stellate cells .
15086471	0	endothelin-1	22,34	NHE3	72,76	endothelin-1	NHE3	24323(Tax:10116)	24784(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3 .
21637825	0	endothelin-1	37,49	NKX2-3	0,6	endothelin-1	NKX2-3	1906	159296	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells .
20188614	0	endothelin-1	78,90	Nkx2-3	19,25	endothelin-1	Nkx2-3	1906	159296	Gene	Gene	implication|nmod|START_ENTITY Genes|dep|implication Genes|acl|regulated regulated|nmod|END_ENTITY	Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells : implication of endothelin-1 in inflammatory_bowel_disease .
25284689	0	endothelin-1	63,75	Nur77	24,29	endothelin-1	Nur77	1906	3164	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Orphan nuclear receptor Nur77 is a novel negative regulator of endothelin-1 expression in vascular endothelial cells .
9683456	0	endothelin-1	23,35	Oncostatin_M	0,12	endothelin-1	Oncostatin M	1906	5008	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Oncostatin_M regulates endothelin-1 production in human endothelial cells .
11602570	0	endothelin-1	22,34	PYK2	0,4	endothelin-1	PYK2	1906	2185	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|nmod|mediator	PYK2 as a mediator of endothelin-1 / G_alpha_11 signaling to GLUT4 glucose transporters .
18518931	0	endothelin-1	44,56	Parathyroid_hormone	0,19	endothelin-1	Parathyroid hormone	1906	5741	Gene	Gene	related|xcomp|START_ENTITY related|nsubjpass|END_ENTITY	Parathyroid_hormone is inversely related to endothelin-1 in patients on haemodialysis .
11078354	0	endothelin-1	95,107	Protein_kinase_C_delta	0,22	endothelin-1	Protein kinase C delta	1906	5580	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Protein_kinase_C_delta but not PKC_epsilon activity is involved in contractile potentiation by endothelin-1 in the porcine coronary artery .
8637106	0	endothelin-1	57,69	Src	85,88	endothelin-1	Src	1906	6714	Gene	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Modulation of monocyte adherence to endothelial cells by endothelin-1 involvement of Src -LRB- p60src -RRB- and JAK1-like kinases .
1566813	0	endothelin-1	34,46	TNF-alpha	55,64	endothelin-1	TNF-alpha	281137(Tax:9913)	280943(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the endothelin-1 gene by TNF-alpha .
2215247	0	endothelin-1	53,65	Thrombin	0,8	endothelin-1	Thrombin	1906	2147	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells stimulates|dobj|production stimulates|nsubj|END_ENTITY	Thrombin stimulates the production of immunoreactive endothelin-1 in cultured human umbilical vein endothelial cells .
7679602	0	endothelin-1	38,50	Thrombin	0,8	endothelin-1	Thrombin	24323(Tax:10116)	29251(Tax:10116)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Thrombin is a regulator of astrocytic endothelin-1 .
9612302	0	endothelin-1	23,35	Thrombin	0,8	endothelin-1	Thrombin	1906	2147	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|compound|END_ENTITY	Thrombin regulation of endothelin-1 gene in isolated human pulmonary endothelial cells .
22287612	0	endothelin-1	39,51	Transforming_growth_factor-b	0,28	endothelin-1	Transforming growth factor-b	13614(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Transforming_growth_factor-b regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure .
15838328	0	endothelin-1	40,52	Transforming_growth_factor-beta	0,31	endothelin-1	Transforming growth factor-beta	1906	7040	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-beta induces endothelin-1 expression through activation of the Smad signaling pathway .
9681709	0	endothelin-1	33,45	Transforming_growth_factor-beta	0,31	endothelin-1	Transforming growth factor-beta	1906	7040	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-beta , endothelin-1 , and c-fos expression in necrotizing/crescentic IgA glomerulonephritis .
11061980	0	endothelin-1	41,53	Transforming_growth_factor-beta1	0,32	endothelin-1	Transforming growth factor-beta1	281137(Tax:9913)	282089(Tax:9913)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-beta1 induces endothelin-1 in a bovine pulmonary artery endothelial cell line and rat lungs via cAMP .
17469009	0	endothelin-1	43,55	Vascular_endothelial_growth_factor	0,34	endothelin-1	Vascular endothelial growth factor	1906	7422	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces endothelin-1 production via matrix_metalloproteinase-2 rather than endothelin-converting_enzyme-1 .
10473669	0	endothelin-1	79,91	activator_protein-1	157,176	endothelin-1	activator protein-1	1906	3725	Gene	Gene	production|amod|START_ENTITY inhibit|dobj|production inhibit|advcl|inhibiting inhibiting|dobj|pathway pathway|amod|END_ENTITY	Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator_protein-1 signaling pathway .
12193048	0	endothelin-1	16,28	activator_protein-1	38,57	endothelin-1	activator protein-1	24323(Tax:10116)	24516(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Contribution of endothelin-1 to renal activator_protein-1 activation and macrophage infiltration in aldosterone-induced hypertension .
14651962	0	endothelin-1	39,51	adiponectin	14,25	endothelin-1	adiponectin	1906	9370	Gene	Gene	secretion|advcl|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of adiponectin secretion by endothelin-1 .
11410113	0	endothelin-1	46,58	adrenomedullin	10,24	endothelin-1	adrenomedullin	1906	133	Gene	Gene	arteries|amod|START_ENTITY production|nmod|arteries END_ENTITY|nmod|production	Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries : evidence for a receptor-specific functional interaction in patients with heart_failure .
11754973	0	endothelin-1	79,91	adrenomedullin	11,25	endothelin-1	adrenomedullin	24323(Tax:10116)	25026(Tax:10116)	Gene	Gene	angiotensin_II|amod|START_ENTITY induced|nmod|angiotensin_II induced|nsubj|Effects Effects|nmod|END_ENTITY	Effects of adrenomedullin on hypertrophic responses induced by angiotensin_II , endothelin-1 and phenylephrine .
12379507	0	endothelin-1	11,23	adrenomedullin	38,52	endothelin-1	adrenomedullin	1906	133	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of endothelin-1 on release of adrenomedullin and C-type_natriuretic_peptide from individual human vascular endothelial cells .
1878760	0	endothelin-1	96,108	alpha-calcitonin_gene-related_peptide	30,67	endothelin-1	alpha-calcitonin gene-related peptide	1906	796	Gene	Gene	administration|nmod|START_ENTITY administration|amod|END_ENTITY	Haemodynamic effects of human alpha-calcitonin_gene-related_peptide following administration of endothelin-1 or NG-nitro-L-arginine_methyl_ester in conscious rats .
10027431	0	endothelin-1	79,91	angiotensin_II	18,32	endothelin-1	angiotensin II	1906	183	Gene	Gene	activity|nmod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of infused angiotensin_II on the bronchoconstrictor activity of inhaled endothelin-1 in asthma .
10501344	0	endothelin-1	53,65	angiotensin_II	15,29	endothelin-1	angiotensin II	1906	183	Gene	Gene	levels|amod|START_ENTITY losartan|nmod|levels losartan|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of the angiotensin_II antagonist losartan on endothelin-1 and norepinephrine plasma levels during cold pressor test in patients with chronic_heart_failure .
11479261	0	endothelin-1	46,58	angiotensin_II	24,38	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibitions|amod|START_ENTITY END_ENTITY|nmod|inhibitions	Differential effects of angiotensin_II versus endothelin-1 inhibitions in hypertrophic_left_ventricular_myocardium during transition to heart_failure .
12410847	0	endothelin-1	8,20	angiotensin_II	77,91	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of endothelin-1 and thromboxane_A2 in renal vasoconstriction induced by angiotensin_II in diabetes and hypertension .
1310444	0	endothelin-1	50,62	angiotensin_II	85,99	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	response|amod|START_ENTITY inhibit|dobj|response inhibit|nmod|END_ENTITY	Atrial and brain_natriuretic_peptides inhibit the endothelin-1 secretory response to angiotensin_II in porcine aorta .
15613065	0	endothelin-1	51,63	angiotensin_II	137,151	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	mediation|nmod|START_ENTITY modifies|dobj|mediation modifies|nmod|response response|nmod|END_ENTITY	AT-1 receptor antagonism modifies the mediation of endothelin-1 , thromboxane_A2 , and catecholamines in the renal constrictor response to angiotensin_II .
15831659	0	endothelin-1	37,49	angiotensin_II	14,28	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression induced|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of angiotensin_II induced endothelin-1 gene expression by 17-beta-oestradiol in rat cardiac fibroblasts .
1645748	0	endothelin-1	55,67	angiotensin_II	101,115	endothelin-1	angiotensin II	1906	183	Gene	Gene	secretion|amod|START_ENTITY atrial|nmod|secretion Inhibition|nmod|atrial Inhibition|nmod|END_ENTITY	Inhibition by atrial and brain_natriuretic_peptides of endothelin-1 secretion after stimulation with angiotensin_II and thrombin of cultured human endothelial cells .
16505203	0	endothelin-1	57,69	angiotensin_II	33,47	endothelin-1	angiotensin II	1906	183	Gene	Gene	species|amod|START_ENTITY role|nmod|species effect|dep|role effect|nmod|END_ENTITY	The positive inotropic effect of angiotensin_II : role of endothelin-1 and reactive oxygen species .
7688575	0	endothelin-1	14,26	angiotensin_II	35,49	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY Regulation|nmod|mRNA Regulation|nmod|END_ENTITY	Regulation of endothelin-1 mRNA by angiotensin_II in rat heart endothelial cells .
8782666	0	endothelin-1	86,98	angiotensin_II	147,161	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	influence|amod|START_ENTITY using|dobj|influence using|nmod|size size|nmod|response response|amod|END_ENTITY	A comparative study of tumour blood flow modification in two rat tumour systems using endothelin-1 and angiotensin_II : influence of tumour size on angiotensin_II response .
9146895	0	endothelin-1	73,85	angiotensin_II	18,32	endothelin-1	angiotensin II	24323(Tax:10116)	24179(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY role|nmod|cells effect|dep|role effect|nmod|END_ENTITY	Trophic effect of angiotensin_II in neonatal rat cardiomyocytes : role of endothelin-1 and non-myocyte cells .
2675840	0	endothelin-1	10,22	arginine-vasopressin	37,57	endothelin-1	arginine-vasopressin	24323(Tax:10116)	24221(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus .
17338155	0	endothelin-1	11,23	atrial_natriuretic_peptide	25,51	endothelin-1	atrial natriuretic peptide	403424(Tax:9615)	608289(Tax:9615)	Gene	Gene	Plasma|amod|START_ENTITY END_ENTITY|nsubj|Plasma	Plasma big endothelin-1 , atrial_natriuretic_peptide , aldosterone , and norepinephrine concentrations in normal Doberman Pinschers and Doberman Pinschers with dilated_cardiomyopathy .
2142091	0	endothelin-1	76,88	atrial_natriuretic_peptide	18,44	endothelin-1	atrial natriuretic peptide	24323(Tax:10116)	24602(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	No major role for atrial_natriuretic_peptide in the vasodilator response to endothelin-1 in the spontaneously hypertensive rat .
8477643	0	endothelin-1	13,25	atrial_natriuretic_peptide	34,60	endothelin-1	atrial natriuretic peptide	24323(Tax:10116)	24602(Tax:10116)	Gene	Gene	doses|nmod|START_ENTITY inhibit|nsubj|doses inhibit|dobj|secretion secretion|amod|END_ENTITY	Low doses of endothelin-1 inhibit atrial_natriuretic_peptide secretion .
8928891	0	endothelin-1	47,59	atrial_natriuretic_peptide	11,37	endothelin-1	atrial natriuretic peptide	403424(Tax:9615)	608289(Tax:9615)	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|advmod|END_ENTITY	Endogenous atrial_natriuretic_peptide inhibits endothelin-1 secretion in dogs with severe congestive_heart_failure .
20531225	0	endothelin-1	28,40	b-5p	14,18	endothelin-1	b-5p	24323(Tax:10116)	574523(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MicroRNA-125a / b-5p inhibits endothelin-1 expression in vascular endothelial cells .
11498983	0	endothelin-1	104,116	c-fos	9,14	endothelin-1	c-fos	1906	2353	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|nsubj|Role Role|nmod|gene gene|amod|END_ENTITY	-LSB- Role of c-fos gene in the pulmonary surfactant synthesis of cultured alveolar type II cells induced by endothelin-1 -RSB- .
1331650	0	endothelin-1	122,134	c-fos	15,20	endothelin-1	c-fos	1906	2353	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|expression expression|amod|END_ENTITY	Stimulation of c-fos and c-jun gene expression and down-regulation of proenkephalin gene expression in C6 glioma cells by endothelin-1 .
15086447	0	endothelin-1	46,58	c-fos	32,37	endothelin-1	c-fos	24323(Tax:10116)	314322(Tax:10116)	Gene	Gene	arteries|amod|START_ENTITY expression|nmod|arteries expression|nmod|mRNA mRNA|amod|END_ENTITY	Force-independent expression of c-fos mRNA by endothelin-1 in rat intact small mesenteric arteries .
8816505	0	endothelin-1	103,115	c-fos	133,138	endothelin-1	c-fos	1906	2353	Gene	Gene	receptors|amod|START_ENTITY propagate|nmod|receptors propagate|nmod|promoter promoter|amod|END_ENTITY	Voltage-insensitive Ca2 + channels and Ca2 + / calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoter .
17663518	0	endothelin-1	10,22	cathepsin_B	95,106	endothelin-1	cathepsin B	1906	1508	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of endothelin-1 in esophageal_squamous_cell_carcinoma invasion and its correlation with cathepsin_B .
22966331	0	endothelin-1	10,22	cyclooxygenase-2	26,42	endothelin-1	cyclooxygenase-2	1906	5743	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of endothelin-1 on cyclooxygenase-2 expression in human hormone refractory_prostate_cancer cells .
10448889	0	endothelin-1	14,26	cyclooxygenase_2	57,73	endothelin-1	cyclooxygenase 2	13614(Tax:10090)	19225(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Modulation by endothelin-1 of lipopolysaccharide-induced cyclooxygenase_2 expression in mouse peritoneal macrophages .
17161492	0	endothelin-1	16,28	cytosolic_phospholipase_A2	51,77	endothelin-1	cytosolic phospholipase A2	24323(Tax:10116)	24653(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|production production|amod|END_ENTITY	LPS exacerbates endothelin-1 induced activation of cytosolic_phospholipase_A2 and thromboxane_A2 production from Kupffer cells of the prefibrotic rat liver .
9593858	0	endothelin-1	34,46	cytosolic_phospholipase_A2	62,88	endothelin-1	cytosolic phospholipase A2	1906	5321	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|release release|amod|END_ENTITY	Role of protein_kinase_C_alpha in endothelin-1 stimulation of cytosolic_phospholipase_A2 and arachidonic_acid release in cultured cat iris sphincter smooth muscle cells .
19638349	0	endothelin-1	54,66	edn1	73,77	endothelin-1	edn1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aldosterone modulates steroid receptor binding to the endothelin-1 gene -LRB- edn1 -RRB- .
10091381	0	endothelin-1	36,48	endothelin-1	53,65	endothelin-1	endothelin-1	1906	1906	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Immunohistochemical localization of endothelin-1 / big endothelin-1 in normal liver , liver cirrhosis and hepatocellular_carcinoma .
10091381	0	endothelin-1	53,65	endothelin-1	36,48	endothelin-1	endothelin-1	1906	1906	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of endothelin-1 / big endothelin-1 in normal liver , liver cirrhosis and hepatocellular_carcinoma .
10195544	0	endothelin-1	21,33	endothelin-1	42,54	endothelin-1	endothelin-1	1906	1906	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Perioperative plasma endothelin-1 and Big endothelin-1 concentrations in elderly patients undergoing major surgical procedures .
10195544	0	endothelin-1	42,54	endothelin-1	21,33	endothelin-1	endothelin-1	1906	1906	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Perioperative plasma endothelin-1 and Big endothelin-1 concentrations in elderly patients undergoing major surgical procedures .
10199843	0	endothelin-1	14,26	endothelin-1	79,91	endothelin-1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY Expression|nmod|receptors Expression|nmod|END_ENTITY	Expression of endothelin-1 , ETA and ETB receptors , and ECE and distribution of endothelin-1 in failing rat heart .
10199843	0	endothelin-1	79,91	endothelin-1	14,26	endothelin-1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|receptors receptors|compound|END_ENTITY	Expression of endothelin-1 , ETA and ETB receptors , and ECE and distribution of endothelin-1 in failing rat heart .
11506463	0	endothelin-1	28,40	endothelin-1	7,19	endothelin-1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Plasma endothelin-1 and big endothelin-1 levels in superior and inferior vena cava during protracted antiorthostatic hypokinetic/hypodynamia in rats .
11506463	0	endothelin-1	7,19	endothelin-1	28,40	endothelin-1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Plasma endothelin-1 and big endothelin-1 levels in superior and inferior vena cava during protracted antiorthostatic hypokinetic/hypodynamia in rats .
15838324	0	endothelin-1	11,23	endothelin-1	32,44	endothelin-1	endothelin-1	403424(Tax:9615)	403424(Tax:9615)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Changes of endothelin-1 and big endothelin-1 levels and action potential duration during myocardial_ischemia-reperfusion in dogs with and without ventricular_fibrillation .
15838324	0	endothelin-1	32,44	endothelin-1	11,23	endothelin-1	endothelin-1	403424(Tax:9615)	403424(Tax:9615)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Changes of endothelin-1 and big endothelin-1 levels and action potential duration during myocardial_ischemia-reperfusion in dogs with and without ventricular_fibrillation .
1629095	0	endothelin-1	11,23	endothelin-1	46,58	endothelin-1	endothelin-1	100009270(Tax:9986)	100009270(Tax:9986)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of endothelin-1 and conversion of big endothelin-1 in the isolated perfused rabbit lung .
1629095	0	endothelin-1	46,58	endothelin-1	11,23	endothelin-1	endothelin-1	100009270(Tax:9986)	100009270(Tax:9986)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of endothelin-1 and conversion of big endothelin-1 in the isolated perfused rabbit lung .
1959670	0	endothelin-1	42,54	endothelin-1	84,96	endothelin-1	endothelin-1	1906	1906	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Phosphoramidon inhibits the generation of endothelin-1 from exogenously applied big endothelin-1 in cultured vascular endothelial cells and smooth muscle cells .
1959670	0	endothelin-1	84,96	endothelin-1	42,54	endothelin-1	endothelin-1	1906	1906	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Phosphoramidon inhibits the generation of endothelin-1 from exogenously applied big endothelin-1 in cultured vascular endothelial cells and smooth muscle cells .
26955847	0	endothelin-1	33,45	endothelin-1	54,66	endothelin-1	endothelin-1	1906	1906	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Clinical and prognostic value of endothelin-1 and big endothelin-1 expression in children with pulmonary_hypertension .
26955847	0	endothelin-1	54,66	endothelin-1	33,45	endothelin-1	endothelin-1	1906	1906	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Clinical and prognostic value of endothelin-1 and big endothelin-1 expression in children with pulmonary_hypertension .
7550091	0	endothelin-1	29,41	endothelin-1	50,62	endothelin-1	endothelin-1	1906	1906	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells .
7550091	0	endothelin-1	50,62	endothelin-1	29,41	endothelin-1	endothelin-1	1906	1906	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells .
8039848	0	endothelin-1	43,55	endothelin-1	75,87	endothelin-1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney .
8039848	0	endothelin-1	75,87	endothelin-1	43,55	endothelin-1	endothelin-1	24323(Tax:10116)	24323(Tax:10116)	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	Phosphoramidon-sensitive conversion of big endothelin-1 and degradation of endothelin-1 in rat kidney .
8372594	0	endothelin-1	28,40	endothelin-1	7,19	endothelin-1	endothelin-1	1906	1906	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Plasma endothelin-1 and big endothelin-1 levels in women with pre-eclampsia .
8372594	0	endothelin-1	7,19	endothelin-1	28,40	endothelin-1	endothelin-1	1906	1906	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Plasma endothelin-1 and big endothelin-1 levels in women with pre-eclampsia .
9595409	0	endothelin-1	26,38	endothelin-1	47,59	endothelin-1	endothelin-1	1906	1906	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Comparison of circulating endothelin-1 and big endothelin-1 levels in unstable versus stable angina_pectoris .
9595409	0	endothelin-1	47,59	endothelin-1	26,38	endothelin-1	endothelin-1	1906	1906	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Comparison of circulating endothelin-1 and big endothelin-1 levels in unstable versus stable angina_pectoris .
8901457	0	endothelin-1	221,233	endothelin-3	197,209	endothelin-1	endothelin-3	100009270(Tax:9986)	100348609(Tax:9986)	Gene	Gene	not|advcl|START_ENTITY END_ENTITY|neg|not	Pharmacological characteristics of endothelin receptors in the rabbit ventricular myocardium : the nonselective endothelin receptor antagonist PD_145065 antagonizes the positive inotropic effect of endothelin-3 but not of endothelin-1 .
18938160	0	endothelin-1	74,86	endothelin_B_receptor	12,33	endothelin-1	endothelin B receptor	24323(Tax:10116)	50672(Tax:10116)	Gene	Gene	optic_neuropathy|amod|START_ENTITY Increase|nmod|optic_neuropathy Increase|nmod|expression expression|compound|END_ENTITY	Increase in endothelin_B_receptor expression in optic nerve astrocytes in endothelin-1 induced chronic experimental optic_neuropathy .
19111903	0	endothelin-1	118,130	endothelin_B_receptor	66,87	endothelin-1	endothelin B receptor	24323(Tax:10116)	50672(Tax:10116)	Gene	Gene	alters|nmod|START_ENTITY alters|dobj|expression expression|nmod|END_ENTITY	Endothelin-1 exposure on postnatal day 7 alters expression of the endothelin_B_receptor and behavioral sensitivity to endothelin-1 on postnatal day 11 .
11953117	0	endothelin-1	16,28	endothelin_receptor-type_A	43,69	endothelin-1	endothelin receptor-type A	1906	1909	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	-LSB- The effects of endothelin-1 and selective endothelin_receptor-type_A antagonist on human renal interstitial fibroblasts in vitro -RSB- .
11482502	0	endothelin-1	64,76	erythropoietin	31,45	endothelin-1	erythropoietin	1906	2056	Gene	Gene	levels|amod|START_ENTITY therapy|nmod|levels therapy|compound|END_ENTITY	Influence of recombinant human erythropoietin therapy on plasma endothelin-1 levels during hemodialysis .
21777087	0	endothelin-1	147,159	erythropoietin	18,32	endothelin-1	erythropoietin	24323(Tax:10116)	24335(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY alters|nmod|ratio alters|nsubj|END_ENTITY	Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric_oxide ratio .
8502330	0	endothelin-1	61,73	erythropoietin	25,39	endothelin-1	erythropoietin	1906	2056	Gene	Gene	artery|amod|START_ENTITY production|nmod|artery Influence|nmod|production Influence|nmod|END_ENTITY	Influence of recombinant erythropoietin on the production of endothelin-1 from human umbilical artery .
8510379	0	endothelin-1	52,64	erythropoietin	18,32	endothelin-1	erythropoietin	1906	2056	Gene	Gene	release|amod|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Recombinant human erythropoietin -LRB- rHuEPO -RRB- increases endothelin-1 release by endothelial cells .
8788598	0	endothelin-1	69,81	erythropoietin	18,32	endothelin-1	erythropoietin	1906	2056	Gene	Gene	synthase|amod|START_ENTITY expression|nmod|synthase regulate|dobj|expression regulate|nsubj|END_ENTITY	Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric_oxide synthase in vascular endothelial cells .
8887285	0	endothelin-1	67,79	erythropoietin	18,32	endothelin-1	erythropoietin	1906	2056	Gene	Gene	prostanoids|amod|START_ENTITY tone|nmod|prostanoids enhances|dobj|tone enhances|nsubj|END_ENTITY	Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids .
9056686	0	endothelin-1	29,41	erythropoietin	11,25	endothelin-1	erythropoietin	1906	2056	Gene	Gene	synthesis|amod|START_ENTITY Effects|nmod|synthesis Effects|nmod|END_ENTITY	Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells .
9817611	0	endothelin-1	24,36	erythropoietin	93,107	endothelin-1	erythropoietin	24323(Tax:10116)	24335(Tax:10116)	Gene	Gene	concentrations|amod|START_ENTITY vessel|dobj|concentrations vessel|nmod|rats rats|acl|treated treated|nmod|END_ENTITY	Plasma and blood vessel endothelin-1 concentrations in hypertensive uremic rats treated with erythropoietin .
14732213	0	endothelin-1	23,35	extracellular_signal-regulated_kinase	56,93	endothelin-1	extracellular signal-regulated kinase	24323(Tax:10116)	24338(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Angiotensin_II induces endothelin-1 gene expression via extracellular_signal-regulated_kinase pathway in rat aortic smooth muscle cells .
18398338	0	endothelin-1	73,85	extracellular_signal-regulated_kinase	106,143	endothelin-1	extracellular signal-regulated kinase	1906	5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Reactive oxygen species mediate oxidized low-density lipoprotein-induced endothelin-1 gene expression via extracellular_signal-regulated_kinase in vascular endothelial cells .
18411415	0	endothelin-1	32,44	hypoxia-inducible_factor-1_alpha	86,118	endothelin-1	hypoxia-inducible factor-1 alpha	1906	3091	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Placenta_growth_factor augments endothelin-1 and endothelin-B_receptor expression via hypoxia-inducible_factor-1_alpha .
18391571	0	endothelin-1	45,57	iNOS	8,12	endothelin-1	iNOS	13614(Tax:10090)	18126(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY function|nmod|transgenic_mice impairs|dobj|function impairs|nsubj|Lack Lack|nmod|END_ENTITY	Lack of iNOS impairs endothelial function in endothelin-1 transgenic_mice .
18758499	0	endothelin-1	27,39	iNOS	51,55	endothelin-1	iNOS	13614(Tax:10090)	18126(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY modulation|nmod|pathway modulation|nmod|END_ENTITY	Distinct modulation of the endothelin-1 pathway in iNOS - / - and eNOS - / - mice .
11342583	0	endothelin-1	8,20	insulin	72,79	endothelin-1	insulin	1906	3630	Gene	Gene	treatment|amod|START_ENTITY leads|nsubj|treatment leads|xcomp|heterologous heterologous|dobj|desensitization desensitization|nmod|END_ENTITY	Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes .
12620701	0	endothelin-1	8,20	insulin	32,39	endothelin-1	insulin	1906	3630	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of endothelin-1 induced by insulin in the regulation of vascular cell growth .
1744120	0	endothelin-1	15,27	insulin	47,54	endothelin-1	insulin	281137(Tax:9913)	280829(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of endothelin-1 gene expression by insulin in endothelial cells .
14500749	0	endothelin-1	137,149	interferon_regulatory_factor-1	86,116	endothelin-1	interferon regulatory factor-1	1906	3659	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Role for nuclear factor-kappaB and signal_transducer_and_activator_of_transcription_1 / interferon_regulatory_factor-1 in cytokine-induced endothelin-1 release in human vascular smooth muscle cells .
16527283	0	endothelin-1	78,90	interleukin-6	53,66	endothelin-1	interleukin-6	1906	3569	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Vitamin_C_blocks_vascular_dysfunction Vitamin_C_blocks_vascular_dysfunction|nmod|END_ENTITY	Vitamin_C_blocks_vascular_dysfunction and release of interleukin-6 induced by endothelin-1 in humans in vivo .
19389001	0	endothelin-1	14,26	interleukin-6	48,61	endothelin-1	interleukin-6	1906	3569	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	The effect of endothelin-1 on the production of interleukin-6 in cultured human detrusor smooth muscle cells , and the effect of interleukin-6 on the contractile response of bladder smooth muscle strips from rats .
22290536	0	endothelin-1	53,65	interleukin-6	25,38	endothelin-1	interleukin-6	13614(Tax:10090)	16193(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic_AMP in adipocytes .
10559137	0	endothelin-1	48,60	matrix_metalloproteinase-2	9,35	endothelin-1	matrix metalloproteinase-2	1906	4313	Gene	Gene	yielding|dep|START_ENTITY yielding|nsubj|cleaves cleaves|amod|END_ENTITY	Vascular matrix_metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor .
17469009	0	endothelin-1	43,55	matrix_metalloproteinase-2	71,97	endothelin-1	matrix metalloproteinase-2	1906	4313	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces endothelin-1 production via matrix_metalloproteinase-2 rather than endothelin-converting_enzyme-1 .
22675930	0	endothelin-1	48,60	matrix_metalloproteinase-9	62,88	endothelin-1	matrix metalloproteinase-9	1906	4318	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Significance expression and relationships with endothelin-1 , matrix_metalloproteinase-9 in the laryngeal_carcinoma -RSB- .
22521293	0	endothelin-1	61,73	p16INK4a	14,22	endothelin-1	p16INK4a	1906	1029	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells .
15051668	0	endothelin-1	89,101	p38_mitogen-activated_protein_kinase	0,36	endothelin-1	p38 mitogen-activated protein kinase	24323(Tax:10116)	81649(Tax:10116)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	p38_mitogen-activated_protein_kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats .
17105827	0	endothelin-1	83,95	peroxisome_proliferator-activated_receptor_alpha	0,48	endothelin-1	peroxisome proliferator-activated receptor alpha	1906	5465	Gene	Gene	production|amod|START_ENTITY regulation|nmod|production regulation|amod|END_ENTITY	peroxisome_proliferator-activated_receptor_alpha activation-mediated regulation of endothelin-1 production via nitric_oxide and protein_kinase_C signaling pathways in piglet cerebral microvascular endothelial cell culture .
1331650	0	endothelin-1	122,134	proenkephalin	70,83	endothelin-1	proenkephalin	1906	5179	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|expression expression|compound|END_ENTITY	Stimulation of c-fos and c-jun gene expression and down-regulation of proenkephalin gene expression in C6 glioma cells by endothelin-1 .
9593858	0	endothelin-1	34,46	protein_kinase_C_alpha	8,30	endothelin-1	protein kinase C alpha	1906	5578	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	Role of protein_kinase_C_alpha in endothelin-1 stimulation of cytosolic_phospholipase_A2 and arachidonic_acid release in cultured cat iris sphincter smooth muscle cells .
17251392	0	endothelin-1	90,102	receptor_activity-modifying_protein_2	21,58	endothelin-1	receptor activity-modifying protein 2	1906	10266	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Hypoxic induction of receptor_activity-modifying_protein_2 alters regulation of pulmonary endothelin-1 by adrenomedullin : induction under normoxia versus inhibition under hypoxia .
9094756	0	endothelin-1	18,30	serine_protease	36,51	endothelin-1	serine protease	1906	2147	Gene	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of big endothelin-1 by a serine_protease in the membrane fraction of human lung .
11798640	0	endothelin-1	26,38	thrombin	91,99	endothelin-1	thrombin	1906	2147	Gene	Gene	START_ENTITY|nmod|proliferation proliferation|acl|stimulated stimulated|nmod|END_ENTITY	-LSB- The mediation effects of endothelin-1 on human mesangial cell proliferation stimulated by thrombin -RSB- .
1472106	0	endothelin-1	34,46	thrombin	22,30	endothelin-1	thrombin	281137(Tax:9913)	280685(Tax:9913)	Gene	Gene	biosynthesis|amod|START_ENTITY mechanism|nmod|biosynthesis mechanism|nmod|END_ENTITY	Cellular mechanism of thrombin on endothelin-1 biosynthesis and release in bovine endothelial cell .
1571476	0	endothelin-1	21,33	thrombin	78,86	endothelin-1	thrombin	1906	2147	Gene	Gene	endothelin-1|amod|START_ENTITY mechanism|nmod|endothelin-1 Release|dobj|mechanism Release|nmod|stimulation stimulation|nmod|END_ENTITY	Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells .
1571476	0	endothelin-1	42,54	thrombin	78,86	endothelin-1	thrombin	1906	2147	Gene	Gene	mechanism|nmod|START_ENTITY Release|dobj|mechanism Release|nmod|stimulation stimulation|nmod|END_ENTITY	Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells .
16222888	0	endothelin-1	31,43	thrombin	69,77	endothelin-1	thrombin	1906	2147	Gene	Gene	production|amod|START_ENTITY production|acl|stimulated stimulated|nmod|END_ENTITY	Electromagnetic_fields inhibit endothelin-1 production stimulated by thrombin in endothelial cells .
1725395	0	endothelin-1	34,46	thrombin	22,30	endothelin-1	thrombin	24323(Tax:10116)	29251(Tax:10116)	Gene	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Stimulatory effect of thrombin on endothelin-1 production in isolated glomeruli and cultured mesangial cells of rats .
8156101	0	endothelin-1	15,27	thrombin	42,50	endothelin-1	thrombin	1906	2147	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Stimulation of endothelin-1 production by thrombin , but lack of interference by high ambient glucose in vitro .
15621731	0	endothelin-1	17,29	vascular_endothelial_growth_factor	121,155	endothelin-1	vascular endothelial growth factor	1906	7422	Gene	Gene	cells|amod|START_ENTITY secretion|nmod|cells inhibited|nsubjpass|secretion inhibited|nmod|END_ENTITY	The secretion of endothelin-1 by microvascular endothelial cells from human benign_prostatic_hyperplasia is inhibited by vascular_endothelial_growth_factor .
23458507	0	endothelin-1	90,102	vascular_endothelial_growth_factor	20,54	endothelin-1	vascular endothelial growth factor	1906	7422	Gene	Gene	focus|nmod|START_ENTITY Hypertension|dep|focus Hypertension|nmod|inhibition inhibition|compound|END_ENTITY	Hypertension during vascular_endothelial_growth_factor inhibition : focus on nitric_oxide , endothelin-1 , and oxidative stress .
24607779	0	endothelin-1	49,61	vascular_endothelial_growth_factor	11,45	endothelin-1	vascular endothelial growth factor	1906	7422	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effects of vascular_endothelial_growth_factor on endothelin-1 production by human lung microvascular endothelial cells in vitro .
23428131	0	endothelin-1_and_inducible_nitric_oxide_synthase	98,146	hypoxia-inducible_factor-1a	69,96	endothelin-1 and inducible nitric oxide synthase	hypoxia-inducible factor-1a	24323(Tax:10116)	29560(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Association between pulmonary_vascular_remodeling and expression of hypoxia-inducible_factor-1a , endothelin-1_and_inducible_nitric_oxide_synthase in pulmonary vessels in neonatal rats with hypoxic_pulmonary_hypertension -RSB- .
10708518	0	endothelin-2	50,62	EDN2	69,73	endothelin-2	EDN2	1907	1907	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The prepro vasoactive intestinal contractor -LRB- VIC -RRB- / endothelin-2 gene -LRB- EDN2 -RRB- : structure , evolution , production , and embryonic expression .
2018043	0	endothelin-2	108,120	EDN2	127,131	endothelin-2	EDN2	1907	1907	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal assignments of the human endothelin family genes : the endothelin-1 gene -LRB- EDN1 -RRB- to 6p23-p24 , the endothelin-2 gene -LRB- EDN2 -RRB- to 1p34 , and the endothelin-3 gene -LRB- EDN3 -RRB- to 20q13.2-q13 .3 .
1701397	0	endothelin-2	29,41	ET-2	43,47	endothelin-2	ET-2	1907	1907	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Specific expression of human endothelin-2 -LRB- ET-2 -RRB- gene in a renal_adenocarcinoma cell line .
1725387	0	endothelin-2	14,26	ET-2	28,32	endothelin-2	ET-2	1907	1907	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of endothelin-2 -LRB- ET-2 -RRB- gene in a human renal_adenocarcinoma cell line : purification and cDNA cloning of ET-2 .
8717152	0	endothelin-2	14,26	ET-2	28,32	endothelin-2	ET-2	1907	1907	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of endothelin-2 -LRB- ET-2 -RRB- on migration and changes in cytosolic free calcium of neutrophils .
22972036	0	endothelin-2	67,79	hypoxia-inducible_factor-1a	21,48	endothelin-2	hypoxia-inducible factor-1a	24324(Tax:10116)	29560(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Regulatory effect of hypoxia-inducible_factor-1a on hCG-stimulated endothelin-2 expression in granulosa cells from the PMSG-treated rat ovary .
10231870	0	endothelin-3	42,54	EDN-3	56,61	endothelin-3	EDN-3	1908	1908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A heterozygous frameshift mutation in the endothelin-3 -LRB- EDN-3 -RRB- gene in isolated Hirschsprung 's _ disease .
19527488	0	endothelin-3	17,29	EDN3	31,35	endothelin-3	EDN3	1908	1908	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Frequent loss of endothelin-3 -LRB- EDN3 -RRB- expression due to epigenetic inactivation in human breast_cancer .
2018043	0	endothelin-3	150,162	EDN3	169,173	endothelin-3	EDN3	1908	1908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal assignments of the human endothelin family genes : the endothelin-1 gene -LRB- EDN1 -RRB- to 6p23-p24 , the endothelin-2 gene -LRB- EDN2 -RRB- to 1p34 , and the endothelin-3 gene -LRB- EDN3 -RRB- to 20q13.2-q13 .3 .
8901457	0	endothelin-3	197,209	endothelin-1	221,233	endothelin-3	endothelin-1	100348609(Tax:9986)	100009270(Tax:9986)	Gene	Gene	START_ENTITY|neg|not not|advcl|END_ENTITY	Pharmacological characteristics of endothelin receptors in the rabbit ventricular myocardium : the nonselective endothelin receptor antagonist PD_145065 antagonizes the positive inotropic effect of endothelin-3 but not of endothelin-1 .
1907563	0	endothelin-3	37,49	prolactin	14,23	endothelin-3	prolactin	366270(Tax:10116)	24683(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of prolactin secretion by endothelin-3 is pertussis toxin-sensitive .
10550517	0	endothelin-A_receptor	35,56	S-0139	69,75	endothelin-A receptor	S-0139	24326(Tax:10116)	1076573(Tax:198215)	Gene	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	A preventive effect of a selective endothelin-A_receptor antagonist , S-0139 , on the erythropoietin-induced reduction_of_the_renal_cortical_blood_flow .
11078347	0	endothelin-B-receptor	39,60	endothelin-1	22,34	endothelin-B-receptor	endothelin-1	50672(Tax:10116)	24323(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Hypotensive effect of endothelin-1 via endothelin-B-receptor pathway on pulmonary circulation is enhanced in rats with pulmonary_hypertension .
17618893	0	endothelin-beta_receptor	15,39	EDNRB	41,46	endothelin-beta receptor	EDNRB	1910	1910	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of endothelin-beta_receptor -LRB- EDNRB -RRB- gene variants in anorectal_malformations .
16540265	0	endothelin-converting_enzyme-1	48,78	ECE-1	80,85	endothelin-converting enzyme-1	ECE-1	230857(Tax:10090)	230857(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organisation of the mouse gene encoding endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- and mRNA expression of ECE-1 isoforms in murine tissues .
23911580	0	endothelin-converting_enzyme-1	14,44	ECE-1	46,51	endothelin-converting enzyme-1	ECE-1	94204(Tax:10116)	94204(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of endothelin-converting_enzyme-1 -LRB- ECE-1 -RRB- by the calcimimetic R-568 .
9462522	0	endothelin-converting_enzyme-1	22,52	Endothelin-1	0,12	endothelin-converting enzyme-1	Endothelin-1	94204(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits endothelin-converting_enzyme-1 expression in cultured rat pulmonary endothelial cells .
11577023	0	endothelin-converting_enzyme-1	70,100	endothelial_nitric_oxide_synthase	20,53	endothelin-converting enzyme-1	endothelial nitric oxide synthase	1889	4846	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Thrombin suppresses endothelial_nitric_oxide_synthase and upregulates endothelin-converting_enzyme-1 expression by distinct pathways : role of Rho/ROCK and mitogen-activated protein kinase .
11145282	0	endothelin-converting_enzyme-1	8,38	nitric_oxide_synthase	74,95	endothelin-converting enzyme-1	nitric oxide synthase	94204(Tax:10116)	24599(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role of endothelin-converting_enzyme-1 in the suppression of constitutive nitric_oxide_synthase in rat gastric_mucosal_injury by indomethacin .
10089138	0	endothelin_1	16,28	IL-1beta	50,58	endothelin 1	IL-1beta	1906	3553	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of endothelin_1 and its precursor by IL-1beta , TNF-alpha , and TGF-beta in the PC3 human prostate_cancer cell line .
8425178	0	endothelin_1	58,70	Interleukin_6	0,13	endothelin 1	Interleukin 6	1906	3569	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin_6 stimulates the production of immunoreactive endothelin_1 in human breast_cancer cells .
1319837	0	endothelin_1	106,118	endothelin_1	38,50	endothelin 1	endothelin 1	1906	1906	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Abundant expression of immunoreactive endothelin_1 in mammary phyllodes tumor : possible paracrine role of endothelin_1 in the growth of stromal cells in phyllodes tumor .
1319837	0	endothelin_1	38,50	endothelin_1	106,118	endothelin 1	endothelin 1	1906	1906	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Abundant expression of immunoreactive endothelin_1 in mammary phyllodes tumor : possible paracrine role of endothelin_1 in the growth of stromal cells in phyllodes tumor .
1495979	0	endothelin_1	31,43	endothelin_1	79,91	endothelin 1	endothelin 1	1906	1906	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	The two-step conversion of big endothelin_1 to endothelin_1 and degradation of endothelin_1 by subcellular fractions from human polymorphonuclear leukocytes .
1495979	0	endothelin_1	79,91	endothelin_1	31,43	endothelin 1	endothelin 1	1906	1906	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	The two-step conversion of big endothelin_1 to endothelin_1 and degradation of endothelin_1 by subcellular fractions from human polymorphonuclear leukocytes .
22431579	0	endothelin_A_receptor	27,48	Endothelin_1	0,12	endothelin A receptor	Endothelin 1	24326(Tax:10116)	24323(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Endothelin_1 activation of endothelin_A_receptor / NADPH oxidase pathway and diminished antioxidants critically contribute to endothelial progenitor cell reduction and dysfunction in salt-sensitive hypertension .
19111903	0	endothelin_B_receptor	66,87	Endothelin-1	0,12	endothelin B receptor	Endothelin-1	50672(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY alters|dobj|expression alters|nsubj|exposure exposure|amod|END_ENTITY	Endothelin-1 exposure on postnatal day 7 alters expression of the endothelin_B_receptor and behavioral sensitivity to endothelin-1 on postnatal day 11 .
24731444	0	endothelin_B_receptor	31,52	Endothelin-1	0,12	endothelin B receptor	Endothelin-1	50672(Tax:10116)	24323(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Endothelin-1 activation of the endothelin_B_receptor modulates pulmonary endothelial CX3CL1 and contributes to pulmonary angiogenesis in experimental_hepatopulmonary_syndrome .
18938160	0	endothelin_B_receptor	12,33	endothelin-1	74,86	endothelin B receptor	endothelin-1	50672(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Increase|nmod|expression Increase|nmod|optic_neuropathy optic_neuropathy|amod|END_ENTITY	Increase in endothelin_B_receptor expression in optic nerve astrocytes in endothelin-1 induced chronic experimental optic_neuropathy .
19111903	0	endothelin_B_receptor	66,87	endothelin-1	118,130	endothelin B receptor	endothelin-1	50672(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY alters|dobj|expression alters|nmod|END_ENTITY	Endothelin-1 exposure on postnatal day 7 alters expression of the endothelin_B_receptor and behavioral sensitivity to endothelin-1 on postnatal day 11 .
25179465	0	endothelin_converting_enzyme_1	43,73	ECE1	75,79	endothelin converting enzyme 1	ECE1	1889	1889	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An arterial-specific enhancer of the human endothelin_converting_enzyme_1 -LRB- ECE1 -RRB- gene is synergistically activated by Sox17 , FoxC2 , and Etv2 .
11953117	0	endothelin_receptor-type_A	43,69	endothelin-1	16,28	endothelin receptor-type A	endothelin-1	1909	1906	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	-LSB- The effects of endothelin-1 and selective endothelin_receptor-type_A antagonist on human renal interstitial fibroblasts in vitro -RSB- .
22407503	0	endothelin_receptor_A	41,62	Transforming_growth_factor-alpha	0,32	endothelin receptor A	Transforming growth factor-alpha	24326(Tax:10116)	24827(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-alpha induces endothelin_receptor_A expression in osteoarthritis .
26166030	0	endothelin_receptor_B	18,39	EDNRB	41,46	endothelin receptor B	EDNRB	1910	1910	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Low expression of endothelin_receptor_B -LRB- EDNRB -RRB- is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid_cystic_carcinoma .
7968263	0	endothelin_receptor_subtype_B	8,37	ET-B	39,43	endothelin receptor subtype B	ET-B	50672(Tax:10116)	50672(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of endothelin_receptor_subtype_B -LRB- ET-B -RRB- in myocardial_ischemia .
22106312	0	endothelin_receptor_type_A	24,50	EDNRA	52,57	endothelin receptor type A	EDNRA	1909	1909	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common variant near the endothelin_receptor_type_A -LRB- EDNRA -RRB- gene is associated with intracranial_aneurysm risk .
24815860	0	endothelin_receptor_type_A	42,68	EDNRA	70,75	endothelin receptor type A	EDNRA	1909	1909	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The evaluation of endothelin_1 -LRB- EDN1 -RRB- and endothelin_receptor_type_A -LRB- EDNRA -RRB- gene polymorphisms in Hashimoto 's _ thyroiditis .
27039359	0	endothelin_receptor_type_B	13,39	EDNRB	41,46	endothelin receptor type B	EDNRB	100033875(Tax:9796)	100033875(Tax:9796)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	New test for endothelin_receptor_type_B -LRB- EDNRB -RRB- mutation genotyping in horses .
24417960	0	endothelin_receptor_type_B	28,54	Myeloperoxidase	0,15	endothelin receptor type B	Myeloperoxidase	1910	4353	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Myeloperoxidase upregulates endothelin_receptor_type_B expression .
18669895	0	endothelin_type_A_receptor	25,51	S-0139	64,70	endothelin type A receptor	S-0139	24326(Tax:10116)	1076573(Tax:198215)	Gene	Gene	effect|nmod|START_ENTITY effect|amod|END_ENTITY	Synergistic effect of an endothelin_type_A_receptor antagonist , S-0139 , with rtPA on the neuroprotection after embolic_stroke .
23423141	0	engrailed-2	33,44	EN-2	46,50	engrailed-2	EN-2	2020	2020	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Complex epigenetic regulation of engrailed-2 -LRB- EN-2 -RRB- homeobox gene in the autism cerebellum .
9740027	0	engrailed-2	87,98	Hoxa5	129,134	engrailed-2	Hoxa5	13799(Tax:10090)	15402(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Regulation of a Purkinje cell-specific promoter by homeodomain proteins : repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7 .
21566742	0	engrailed-2	18,29	en-2	31,35	engrailed-2	en-2	2020	2020	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Oncogenic role of engrailed-2 -LRB- en-2 -RRB- in prostate_cancer cell growth and survival .
23792601	0	enhancer_of_zeste_homolog_2	14,41	EZH2	43,47	enhancer of zeste homolog 2	EZH2	2146	2146	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Inhibition of enhancer_of_zeste_homolog_2 -LRB- EZH2 -RRB- expression is associated with decreased tumor cell proliferation , migration , and invasion in endometrial_cancer cell lines .
25294424	0	enhancer_of_zeste_human_homolog_2	18,51	EZH2	53,57	enhancer of zeste human homolog 2	EZH2	2146	2146	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Overexpression of enhancer_of_zeste_human_homolog_2 -LRB- EZH2 -RRB- gene in human_cytomegalovirus positive glioblastoma multiforme tissues .
12381872	0	enhancing_factor	53,69	phospholipase_A2	86,102	enhancing factor	phospholipase A2	18780(Tax:10090)	18780(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Comparison of the activities of wild type and mutant enhancing_factor / mouse secretory phospholipase_A2 proteins .
277953	0	enkephalin	34,44	enkephalin	61,71	enkephalin	enkephalin	29237(Tax:10116)	29237(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	In vitro release of -LSB- 5-methionine -RSB- enkephalin and -LSB- 5-leucine -RSB- - enkephalin from the rat globus pallidus .
277953	0	enkephalin	61,71	enkephalin	34,44	enkephalin	enkephalin	29237(Tax:10116)	29237(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	In vitro release of -LSB- 5-methionine -RSB- enkephalin and -LSB- 5-leucine -RSB- - enkephalin from the rat globus pallidus .
7068102	0	enkephalin	25,35	prolactin	39,48	enkephalin	prolactin	29237(Tax:10116)	24683(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|compound|END_ENTITY	The effect of methionine enkephalin on prolactin and luteinizing hormone levels in intact and castrated rats .
2524403	0	enkephalinase	20,33	CALLA	142,147	enkephalinase	CALLA	4311	4311	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Characterisation of enkephalinase -LRB- EC 3.4.24.11 -RRB- activity on various leukemic cells expressing the common_acute_lymphocytic_leukemia_antigen -LRB- CALLA -RRB- .
8923854	0	enkephalinase	62,75	Transforming_growth_factor-beta	0,31	enkephalinase	Transforming growth factor-beta	4311	7040	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits progesterone-induced enkephalinase expression in human endometrial stromal cells .
8325937	0	enkephalinase	43,56	Transforming_growth_factor-beta_1	0,33	enkephalinase	Transforming growth factor-beta 1	4311	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits enkephalinase -LRB- EC 3.4.24.11 -RRB- gene expression in human endometrial stromal cells and sex skin fibroblasts in culture .
8445036	0	enkephalinase	56,69	membrane_metalloendopeptidase	25,54	enkephalinase	membrane metalloendopeptidase	4311	4311	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cellular localization of membrane_metalloendopeptidase -LRB- enkephalinase -RRB- in human endometrium during the ovarian cycle .
3276960	0	enkephalinase	16,29	metalloendopeptidase	40,60	enkephalinase	metalloendopeptidase	24590(Tax:10116)	64517(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of enkephalinase -LRB- membrane metalloendopeptidase , E.C. 3.4.24.11 -RRB- in rat organs .
26463133	0	enkephalinase	57,70	opiorphin	117,126	enkephalinase	opiorphin	4311	58503	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin , a pain perception related peptide .
23446454	0	eno4	61,65	enolase_4	50,59	eno4	enolase 4	226265(Tax:10090)	226265(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Disruption of a spermatogenic cell-specific mouse enolase_4 -LRB- eno4 -RRB- gene causes sperm structural defects and male_infertility .
19223001	0	enolase	87,94	ENO1	96,100	enolase	ENO1	843741(Tax:3702)	843741(Tax:3702)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular and functional characterization of the plastid-localized Phosphoenolpyruvate enolase -LRB- ENO1 -RRB- from Arabidopsis_thaliana .
23446454	0	enolase_4	50,59	eno4	61,65	enolase 4	eno4	226265(Tax:10090)	226265(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Disruption of a spermatogenic cell-specific mouse enolase_4 -LRB- eno4 -RRB- gene causes sperm structural defects and male_infertility .
9073515	0	enoyl-CoA_hydratase	20,39	ECHS1	46,51	enoyl-CoA hydratase	ECHS1	1892	1892	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human mitochondrial enoyl-CoA_hydratase gene -LRB- ECHS1 -RRB- : structural organization and assignment to chromosome 10q26.2-q26 .3 .
23394833	0	ensconsin	32,41	kinesin-1	70,79	ensconsin	kinesin-1	38491(Tax:7227)	39445(Tax:7227)	Gene	Gene	cofactor|nsubj|START_ENTITY cofactor|nmod|END_ENTITY	The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1 .
12480912	0	entactin-1	82,92	nidogen-1	93,102	entactin-1	nidogen-1	18073(Tax:10090)	18073(Tax:10090)	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	Neurologic_defects and selective disruption of basement membranes in mice lacking entactin-1 / nidogen-1 .
17937286	0	enterococcal_surface_protein	17,45	esp	47,50	enterococcal surface protein	esp	246777	246777	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Incidence of the enterococcal_surface_protein -LRB- esp -RRB- gene in human and animal fecal sources .
19031895	0	enterococcal_surface_protein	32,60	esp	62,65	enterococcal surface protein	esp	246777	246777	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Environmental occurrence of the enterococcal_surface_protein -LRB- esp -RRB- gene is an unreliable indicator of human fecal contamination .
10067695	0	env	39,42	CD8	9,12	env	CD8	155971(Tax:11676)	925	Gene	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Enhanced CD8 + T cell response to HIV-1 env by combined immunization with influenza and vaccinia_virus recombinants .
10692254	0	env	70,73	ERV-3	64,69	env	ERV-3	30816	2086	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model , BeWo .
10427470	0	env	71,74	ERV3	115,119	env	ERV3	30816	2086	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3 .
18275350	0	env	26,29	HLA-B	51,56	env	HLA-B	100616444	3106	Gene	Gene	epitope|compound|START_ENTITY epitope|acl|presented presented|nmod|END_ENTITY	Targeting of a CD8 T cell env epitope presented by HLA-B * 5802 is associated with markers of HIV_disease_progression and lack of selection pressure .
10466793	0	env	17,20	NDK	65,68	env	NDK	155971(Tax:11676)	4833	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Mutations in the env gene of human_immunodeficiency_virus_type_1 NDK isolates and the use of African_green_monkey CXCR4 as a co-receptor in COS-7 cells .
20042504	0	env	23,26	Rag2	39,43	env	Rag2	155971(Tax:11676)	19374(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Evolution of the HIV-1 env gene in the Rag2 - / - gammaC - / - humanized mouse model .
15777852	0	env	20,23	Rev	44,47	env	Rev	155971(Tax:11676)	155908(Tax:11676)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Regulation of HIV-1 env mRNA translation by Rev protein .
11850847	0	env	92,95	erythropoietin_receptor	50,73	env	erythropoietin receptor	30816	2057	Gene	Gene	gene|compound|START_ENTITY activation|nmod|gene activation|compound|END_ENTITY	Oncogene cooperativity_in_Friend_erythroleukemia : erythropoietin_receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU .1 , independent of SFFV proviral insertion .
18485543	0	env	20,23	gp160	24,29	env	gp160	155971(Tax:11676)	155971(Tax:11676)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses .
19769157	0	envelope	25,33	Env	35,38	envelope	Env	155971(Tax:11676)	155971(Tax:11676)	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	-LSB- The impact of the HIV-1 envelope -LRB- Env -RRB- mutation on its assembly of functional pseudovirus -RSB- .
2968406	0	envelope_protein	88,104	IFN-gamma	6,15	envelope protein	IFN-gamma	64006	3458	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|production production|compound|END_ENTITY	Human IFN-gamma production is inhibited by a synthetic peptide homologous to retroviral envelope_protein .
23132852	0	envelope_protein	12,28	signal_peptide_peptidase-like_3	48,79	envelope protein	signal peptide peptidase-like 3	64006	121665	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Foamy virus envelope_protein is a substrate for signal_peptide_peptidase-like_3 -LRB- SPPL3 -RRB- .
25100841	0	eomesodermin	5,17	CD57	35,39	eomesodermin	CD57	8320	27087	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
17566017	0	eomesodermin	31,43	CD8	53,56	eomesodermin	CD8	8320	925	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|activity activity|nummod|END_ENTITY	The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal_cancer .
18523274	0	eomesodermin	131,143	CD8	56,59	eomesodermin	CD8	8320	925	Gene	Gene	molecules|dep|START_ENTITY expression|nmod|molecules facilitates|nmod|expression facilitates|dobj|response response|compound|END_ENTITY	Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules -LRB- eomesodermin and its targets : perforin and granzyme_B -RRB- .
25100841	0	eomesodermin	5,17	CD8	41,44	eomesodermin	CD8	8320	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
25100841	0	eomesodermin	5,17	CD8	67,70	eomesodermin	CD8	8320	925	Gene	Gene	expression|compound|START_ENTITY identifies|nsubj|expression identifies|dobj|subset subset|compound|END_ENTITY	High eomesodermin expression among CD57 + CD8 + T cells identifies a CD8 + T cell subset associated with viral control during chronic human_immunodeficiency_virus_infection .
25207963	0	eomesodermin	24,36	Interleukin-4	0,13	eomesodermin	Interleukin-4	13813(Tax:10090)	16189(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Interleukin-4 regulates eomesodermin in CD8 + T cell development and differentiation .
20146743	0	eos1	43,47	IZH2	60,64	eos1	IZH2	855644(Tax:4932)	854160(Tax:4932)	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Multicopy suppression of oxidant-sensitive eos1 mutation by IZH2 in Saccharomyces_cerevisiae and the involvement of Eos1 in zinc homeostasis .
15058383	0	eosinophil-associated_ribonuclease_2	71,107	mEar_2	109,115	eosinophil-associated ribonuclease 2	mEar 2	13587(Tax:10090)	13587(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated_ribonuclease_2 -LRB- mEar_2 -RRB- gene .
9363923	0	eosinophil-derived_neurotoxin	34,63	IL-8	14,18	eosinophil-derived neurotoxin	IL-8	6036	3576	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of IL-8 and release of eosinophil-derived_neurotoxin by normal peripheral blood eosinophils .
10534126	0	eosinophil-derived_neurotoxin	36,65	RNS2	66,70	eosinophil-derived neurotoxin	RNS2	6036	6036	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	C/EBP regulates the promoter of the eosinophil-derived_neurotoxin / RNS2 gene in human eosinophilic cells .
9490699	0	eosinophil-derived_neurotoxin	86,115	RNS2	117,121	eosinophil-derived neurotoxin	RNS2	6036	6036	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of transcription factor PU .1 in the activity of the intronic enhancer of the eosinophil-derived_neurotoxin -LRB- RNS2 -RRB- gene .
11699410	0	eosinophil_cationic_protein	20,47	ECP	49,52	eosinophil cationic protein	ECP	6037	6037	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	The serum levels of eosinophil_cationic_protein -LRB- ECP -RRB- are related to the infiltration of eosinophils in the tumours of patients with Hodgkin 's _ disease .
16434694	0	eosinophil_cationic_protein	54,81	ECP	49,52	eosinophil cationic protein	ECP	6037	6037	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A -LRB- G - > C -RRB- transversion in the 3 ' UTR of the human ECP -LRB- eosinophil_cationic_protein -RRB- gene correlates to the cellular content of ECP .
21679745	0	eosinophil_cationic_protein	10,37	ECP	39,42	eosinophil cationic protein	ECP	6037	6037	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of eosinophil_cationic_protein -LRB- ECP -RRB- on Hodgkin_lymphoma cell lines .
7976792	0	eosinophil_cationic_protein	11,38	ECP	40,43	eosinophil cationic protein	ECP	6037	6037	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of eosinophil_cationic_protein -LRB- ECP -RRB- in anaphylactoid anaesthetic reactions in vivo and in vitro .
8060919	0	eosinophil_cationic_protein	41,68	ECP	70,73	eosinophil cationic protein	ECP	6037	6037	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Serum soluble IL-2_receptor -LRB- sIL-2R -RRB- and eosinophil_cationic_protein -LRB- ECP -RRB- levels in atopic_dermatitis .
9250255	0	eosinophil_cationic_protein	31,58	ECP	60,63	eosinophil cationic protein	ECP	6037	6037	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Comparison of sputum and serum eosinophil_cationic_protein -LRB- ECP -RRB- levels in nonatopic asthma and chronic_obstructive_pulmonary_disease .
9578914	0	eosinophil_cationic_protein	6,33	ECP	35,38	eosinophil cationic protein	ECP	6037	6037	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum eosinophil_cationic_protein -LRB- ECP -RRB- levels in patients with seasonal_allergic_rhinitis and allergic_asthma .
24177377	0	eosinophil_cationic_protein	6,33	mast_cell_tryptase	49,67	eosinophil cationic protein	mast cell tryptase	6037	25823	Gene	Gene	superior|nsubj|START_ENTITY superior|xcomp|END_ENTITY	Serum eosinophil_cationic_protein is superior to mast_cell_tryptase as marker for response to topical corticosteroid therapy in eosinophilic_esophagitis .
22552881	0	eosinophil_major_basic_protein	33,63	Gfi-1	0,5	eosinophil major basic protein	Gfi-1	5553	2672	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Gfi-1 inhibits the expression of eosinophil_major_basic_protein -LRB- MBP -RRB- during G-CSF-induced neutrophilic differentiation .
8473484	0	eosinophil_major_basic_protein	6,36	muscarinic_M2_receptor	94,116	eosinophil major basic protein	muscarinic M2 receptor	5553	1129	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	Human eosinophil_major_basic_protein is an endogenous allosteric antagonist at the inhibitory muscarinic_M2_receptor .
10850854	0	eosinophil_peroxidase	87,108	EPO	110,113	eosinophil peroxidase	EPO	303414(Tax:10116)	303414(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil_peroxidase -LRB- EPO -RRB- levels following either systemic or intratracheal administration in sephadex - or ovalbumin-induced inflammatory models .
9188923	0	eosinophil_peroxidase	6,27	EPO	29,32	eosinophil peroxidase	EPO	8288	8288	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Serum eosinophil_peroxidase -LRB- EPO -RRB- levels in asthmatic patients .
8773591	0	eosinophil_peroxidase	22,43	mEPO	50,54	eosinophil peroxidase	mEPO	13861(Tax:10090)	13856(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the murine eosinophil_peroxidase gene -LRB- mEPO -RRB- : characterization of a conserved subgroup of mammalian hematopoietic peroxidases .
10072486	0	eotaxin	85,92	IL-13	62,67	eotaxin	IL-13	20292(Tax:10090)	16163(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Effects of Th2 cytokines on chemokine expression in the lung : IL-13 potently induces eotaxin expression by airway epithelial cells .
10623861	0	eotaxin	69,76	IL-18	22,27	eotaxin	IL-18	20292(Tax:10090)	16173(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	Differential roles of IL-18 in allergic_airway_disease : induction of eotaxin by resident cell populations exacerbates eosinophil accumulation .
21646790	0	eotaxin	84,91	IL-33	26,31	eotaxin	IL-33	20292(Tax:10090)	77125(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production Expression|parataxis|induces Expression|nmod|END_ENTITY	Expression and effects of IL-33 and ST2 in allergic bronchial_asthma : IL-33 induces eotaxin production in lung fibroblasts .
21646790	0	eotaxin	84,91	IL-33	70,75	eotaxin	IL-33	20292(Tax:10090)	77125(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Expression and effects of IL-33 and ST2 in allergic bronchial_asthma : IL-33 induces eotaxin production in lung fibroblasts .
16547273	0	eotaxin	61,68	IL-4	53,57	eotaxin	IL-4	20292(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression : involvement of STAT6 .
10050668	0	eotaxin	61,68	Mac-1	87,92	eotaxin	Mac-1	20292(Tax:10090)	16409(Tax:10090)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1 / ICAM-1 and VLA-4 / VCAM-1 interactions .
12496442	0	eotaxin	23,30	Oncostatin_M	0,12	eotaxin	Oncostatin M	20292(Tax:10090)	18413(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Oncostatin_M regulates eotaxin expression in fibroblasts and eosinophilic inflammation in C57BL/6 mice .
19799897	0	eotaxin	50,57	Oncostatin_M	0,12	eotaxin	Oncostatin M	20292(Tax:10090)	18413(Tax:10090)	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|dep|responses	Oncostatin_M -LRB- OSM -RRB- primes IL-13 - _ and_IL-4-induced eotaxin responses in fibroblasts : regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1 .
14733929	0	eotaxin	51,58	SOCS-1	18,24	eotaxin	SOCS-1	20292(Tax:10090)	12703(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	IFN-gamma-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-alpha .
18380907	0	eotaxin-1	34,43	CCL-11	27,33	eotaxin-1	CCL-11	6356	6356	Gene	Gene	IL-8|dep|START_ENTITY IL-8|compound|END_ENTITY	Differential regulation of CCL-11 / eotaxin-1 and CXCL-8 / IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells .
16755001	0	eotaxin-1	27,36	CCL26	57,62	eotaxin-1	CCL26	6356	10344	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	Differential regulation of eotaxin-1 / CCL11 and eotaxin-3 / CCL26 production by the TNF-alpha and IL-4 stimulated human lung fibroblast .
16951370	0	eotaxin-1	15,24	IL-17A	0,6	eotaxin-1	IL-17A	6356	3605	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	IL-17A induces eotaxin-1 / CC chemokine ligand 11 expression in human airway_smooth_muscle cells : role of MAPK -LRB- Erk1/2 , JNK , and p38 -RRB- pathways .
15753898	0	eotaxin-1	20,29	IL-4	78,82	eotaxin-1	IL-4	6356	3565	Gene	Gene	release|amod|START_ENTITY causes|dobj|release causes|parataxis|synergy synergy|nmod|END_ENTITY	Oncostatin_M causes eotaxin-1 release from airway smooth muscle : synergy with IL-4 and IL-13 .
22114952	0	eotaxin-1	62,71	MMP-3	14,19	eotaxin-1	MMP-3	6356	4314	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of MMP-3 expression and secretion by the chemokine eotaxin-1 in human chondrocytes .
25111027	0	eotaxin-1	20,29	STAT6	49,54	eotaxin-1	STAT6	6356	6778	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway .
12370400	0	eotaxin-1	44,53	TGF-beta	0,8	eotaxin-1	TGF-beta	6356	7040	Gene	Gene	production|amod|START_ENTITY increase|dobj|production increase|nsubj|END_ENTITY	TGF-beta and IL-13 synergistically increase eotaxin-1 production in human airway fibroblasts .
16682802	0	eotaxin-2	41,50	CCL24	52,57	eotaxin-2	CCL24	6369	6369	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Endothelial and epithelial expression of eotaxin-2 -LRB- CCL24 -RRB- in nasal_polyps .
17917245	0	eotaxin-2	29,38	CCL24	39,44	eotaxin-2	CCL24	6369	6369	Gene	Gene	Production|nmod|START_ENTITY Production|dep|END_ENTITY	Production and regulation of eotaxin-2 / CCL24 in a differentiated human leukemic cell line , HT93 .
14616792	0	eotaxin-2	69,78	CCL26	51,56	eotaxin-2	CCL26	6369	10344	Gene	Gene	not|nmod|START_ENTITY END_ENTITY|dep|not	Significant elevation of serum levels of eotaxin-3 / CCL26 , but not of eotaxin-2 / CCL24 , in patients with atopic_dermatitis : serum eotaxin-3 / CCL26 levels reflect the disease activity of atopic_dermatitis .
12061839	0	eotaxin-3	20,29	CCL26	30,35	eotaxin-3	CCL26	10344	10344	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Regulation of human eotaxin-3 / CCL26 expression : modulation by cytokines and glucocorticoids .
14616792	0	eotaxin-3	41,50	CCL26	138,143	eotaxin-3	CCL26	10344	10344	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Significant elevation of serum levels of eotaxin-3 / CCL26 , but not of eotaxin-2 / CCL24 , in patients with atopic_dermatitis : serum eotaxin-3 / CCL26 levels reflect the disease activity of atopic_dermatitis .
18844613	0	eotaxin-3	73,82	CCL26	83,88	eotaxin-3	CCL26	10344	10344	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Treatment with topical steroids downregulates IL-5 , eotaxin-1 / CCL11 , and eotaxin-3 / CCL26 gene expression in eosinophilic_esophagitis .
22206772	0	eotaxin-3	13,22	PGD2	0,4	eotaxin-3	PGD2	10344	5730	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	PGD2 induces eotaxin-3 via PPARy from sebocytes : a possible pathogenesis of eosinophilic_pustular_folliculitis .
16428072	0	eotaxin_1	33,42	STAT6	58,63	eotaxin 1	STAT6	6356	6778	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Glycyrrhizin derivative inhibits eotaxin_1 production via STAT6 in human lung fibroblasts .
11146556	0	ephrin-A1	4,13	EphA2	39,44	ephrin-A1	EphA2	1942	1969	Gene	Gene	ligand|amod|START_ENTITY ligand|appos|END_ENTITY	The ephrin-A1 ligand and its receptor , EphA2 , are expressed during tumor neovascularization .
22173506	0	ephrin-A1	10,19	EphA2	20,25	ephrin-A1	EphA2	1942	1969	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of ephrin-A1 / EphA2 on invasion of trophoblastic cells .
23661698	0	ephrin-A1	63,72	EphA2	97,102	ephrin-A1	EphA2	1942	1969	Gene	Gene	glycosylation|nmod|START_ENTITY characterization|nmod|glycosylation characterization|appos|kinase kinase|amod|ligand ligand|nmod|tyrosine tyrosine|amod|END_ENTITY	Biological and structural characterization of glycosylation on ephrin-A1 , a preferred ligand for EphA2 receptor tyrosine kinase .
20154726	0	ephrin-A1	98,107	Hic1	38,42	ephrin-A1	Hic1	13636(Tax:10090)	15248(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A potential tumor suppressor role for Hic1 in breast_cancer through transcriptional repression of ephrin-A1 .
18092944	0	ephrin-B1	27,36	EphB2	62,67	ephrin-B1	EphB2	1947	2048	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression and function of ephrin-B1 and its cognate receptor EphB2 in human atherosclerosis : from an aspect of chemotaxis .
15663472	0	ephrinB2	128,136	EphB1	114,119	ephrinB2	EphB1	13642(Tax:10090)	270190(Tax:10090)	Gene	Gene	ligand|appos|START_ENTITY ligand|amod|END_ENTITY	Nurr1 co-localizes with EphB1 receptors in the developing ventral midbrain , and its expression is enhanced by the EphB1 ligand , ephrinB2 .
12734395	0	ephrinB2	94,102	EphB4	8,13	ephrinB2	EphB4	1948	2050	Gene	Gene	cells|amod|START_ENTITY controls|nmod|cells controls|nsubj|END_ENTITY	Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells .
19864302	0	ephrinB2	11,19	NR2B	122,126	ephrinB2	NR2B	1948	2904	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|sensitization sensitization|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B .
18434321	0	ephrin_A1	124,133	Hypoxia-inducible_transcription_factor-2alpha	0,45	ephrin A1	Hypoxia-inducible transcription factor-2alpha	13636(Tax:10090)	13819(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Hypoxia-inducible_transcription_factor-2alpha in endothelial cells regulates tumor neovascularization through activation of ephrin_A1 .
11278471	0	ephrin_A1	53,62	Tumor_necrosis_factor-alpha	0,27	ephrin A1	Tumor necrosis factor-alpha	1942	7124	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Tumor_necrosis_factor-alpha induction of endothelial ephrin_A1 expression is mediated by a p38 MAPK - and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism .
7989108	0	epidermal-growth-factor	153,176	EGF	178,181	epidermal-growth-factor	EGF	1950	1950	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Presence of immunoassayable transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- in breast cyst fluid -LRB- BCF -RRB- : relationship with the intracystic electrolyte and epidermal-growth-factor -LRB- EGF -RRB- content .
21559666	0	epidermal_growth-factor_receptor	13,45	egfr	47,51	epidermal growth-factor receptor	egfr	1956	1956	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The value of epidermal_growth-factor_receptor -LRB- egfr -RRB- as a tumor-marker for human oral premalignant and malignant_lesions .
21566906	0	epidermal_growth-factor_receptor	101,133	p53	20,23	epidermal growth-factor receptor	p53	1956	7157	Gene	Gene	cathepsin-d|amod|START_ENTITY value|amod|cathepsin-d value|nmod|expression expression|compound|END_ENTITY	Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis , epidermal_growth-factor_receptor , C-erbb-2 , cathepsin-d , DNA-ploidy , parameters of cell-kinetics and conventional features .
19121340	0	epidermal_growth_factor	16,39	Bcl-XL	0,6	epidermal growth factor	Bcl-XL	1950	598	Gene	Gene	START_ENTITY|nsubj|mediates mediates|compound|END_ENTITY	Bcl-XL mediates epidermal_growth_factor dependent cell survival in HC11 mammary epithelial cells .
23982810	0	epidermal_growth_factor	135,158	CXCR4	180,185	epidermal growth factor	CXCR4	13645(Tax:10090)	12767(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Vascular_endothelial_growth_factor_receptor_1 signaling facilitates gastric ulcer_healing and angiogenesis through the upregulation of epidermal_growth_factor expression on VEGFR1 + CXCR4 + cells recruited from bone marrow .
16394175	0	epidermal_growth_factor	10,33	CYP19	84,89	epidermal growth factor	CYP19	1950	1588	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of epidermal_growth_factor and prostaglandin on the expression of aromatase -LRB- CYP19 -RRB- in human adrenocortical_carcinoma cell line NCI-H295R cells .
12138161	0	epidermal_growth_factor	20,43	Crk	0,3	epidermal growth factor	Crk	1950	1398	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Crk synergizes with epidermal_growth_factor for epithelial invasion and morphogenesis and is required for the met morphogenic program .
10445389	0	epidermal_growth_factor	13,36	EGF	38,41	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of epidermal_growth_factor -LRB- EGF -RRB- on renal transport of PAH and amino_acids in amino_acid loaded rats .
10613783	0	epidermal_growth_factor	11,34	EGF	36,39	epidermal growth factor	EGF	100008808(Tax:9986)	100008808(Tax:9986)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of epidermal_growth_factor -LRB- EGF -RRB- on the development of EGF-receptor -LRB- EGF-R -RRB- binding in fetal rabbit lung organ culture .
11913544	0	epidermal_growth_factor	11,34	EGF	36,39	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of epidermal_growth_factor -LRB- EGF -RRB- on fetal islet B cells in vitro .
12012272	0	epidermal_growth_factor	10,33	EGF	35,38	epidermal growth factor	EGF	100008808(Tax:9986)	100008808(Tax:9986)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on steroid and cyclic nucleotide secretion , proliferation and ERK-related MAP-kinase in cultured rabbit granulosa cells .
15889422	0	epidermal_growth_factor	50,73	EGF	45,48	epidermal growth factor	EGF	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Role of thyroid hormone in the initiation of EGF -LRB- epidermal_growth_factor -RRB- expression in the sublingual gland of the postnatal mouse .
17629036	0	epidermal_growth_factor	25,48	EGF	50,53	epidermal growth factor	EGF	1950	1950	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of epidermal_growth_factor -LRB- EGF -RRB- expression in gastric_cancer .
17663016	0	epidermal_growth_factor	100,123	EGF	125,128	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Urine acidification has no effect on peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- signaling or epidermal_growth_factor -LRB- EGF -RRB- expression in rat urinary bladder urothelium .
18672282	0	epidermal_growth_factor	20,43	EGF	45,48	epidermal growth factor	EGF	1950	1950	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the epidermal_growth_factor -LRB- EGF -RRB- in the epididymis and accessory genital glands of the boar and functional effects on spermatozoa .
19166012	0	epidermal_growth_factor	22,45	EGF	47,50	epidermal growth factor	EGF	1950	1950	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of exogenous epidermal_growth_factor -LRB- EGF -RRB- on growth inhibition induced by aristolochic_acid_I -LRB- AA-I -RRB- in renal proximal tubular epithelial cells -RSB- .
1920276	0	epidermal_growth_factor	11,34	EGF	36,39	epidermal growth factor	EGF	1950	1950	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of epidermal_growth_factor -LRB- EGF -RRB- to a cultured human glioma cell line .
1928747	0	epidermal_growth_factor	22,45	EGF	47,50	epidermal growth factor	EGF	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of epidermal_growth_factor -LRB- EGF -RRB- , EGF receptor and transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- during murine palatogenesis in vivo and in vitro .
19336395	0	epidermal_growth_factor	46,69	EGF	71,74	epidermal growth factor	EGF	1950	1950	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The intracellular juxtamembrane domain of the epidermal_growth_factor _ -LRB- EGF -RRB- _ receptor is responsible for the allosteric regulation of EGF binding .
19853299	0	epidermal_growth_factor	13,36	EGF	38,41	epidermal growth factor	EGF	1950	1950	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	p53 Mediates epidermal_growth_factor -LRB- EGF -RRB- induction of MMP-2 transcription and trophoblast invasion .
1995079	0	epidermal_growth_factor	10,33	EGF	35,38	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on gluconeogenesis in isolated rat hepatocytes .
20203692	0	epidermal_growth_factor	13,36	EGF	38,41	epidermal growth factor	EGF	1950	1950	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A functional epidermal_growth_factor -LRB- EGF -RRB- polymorphism , EGF serum levels and renal_cell_carcinoma risk in a Chinese population .
2049180	0	epidermal_growth_factor	14,37	EGF	39,42	epidermal growth factor	EGF	1950	1950	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	The action of epidermal_growth_factor -LRB- EGF -RRB- is limited to specific phases of the cell cycle in an EGF dependent colonic cell line .
2271554	0	epidermal_growth_factor	16,39	EGF	60,63	epidermal growth factor	EGF	1950	1950	Gene	Gene	site|compound|START_ENTITY site|nmod|receptor receptor|compound|END_ENTITY	Location of the epidermal_growth_factor binding site on the EGF receptor .
22931872	0	epidermal_growth_factor	24,47	EGF	49,52	epidermal growth factor	EGF	100008808(Tax:9986)	100008808(Tax:9986)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	-LSB- Therapeutic effects of epidermal_growth_factor -LRB- EGF -RRB- combined with plasma cryoprecipitate -LRB- CRYO -RRB- on the corneal_injury induced by paraquat -RSB- .
23270918	0	epidermal_growth_factor	15,38	EGF	40,43	epidermal growth factor	EGF	106502173	106502173	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of epidermal_growth_factor -LRB- EGF -RRB- on the in vitro development of isolated goat secondary follicles and the relative mRNA expression of EGF , EGF-R , FSH-R and P450 aromatase in cultured follicles .
2389590	0	epidermal_growth_factor	18,41	EGF	43,46	epidermal growth factor	EGF	1950	1950	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	-LSB- Determination of epidermal_growth_factor -LRB- EGF -RRB- receptors in basal_cell_carcinomas , squamous_cell_carcinomas and melanomas -RSB- .
2532289	0	epidermal_growth_factor	36,59	EGF	61,64	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	-LSB- Effect of experimental diabetes on epidermal_growth_factor -LRB- EGF -RRB- receptors in the rat liver -RSB- .
2602718	0	epidermal_growth_factor	11,34	EGF	36,39	epidermal growth factor	EGF	1950	1950	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of epidermal_growth_factor -LRB- EGF -RRB- on proliferation of the cells derived from the root resorbing tissue of human deciduous teeth -RSB- .
2784840	0	epidermal_growth_factor	22,45	EGF	47,50	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of uterine epidermal_growth_factor -LRB- EGF -RRB- receptors by estrogen in the mature rat and during the estrous cycle .
2957293	0	epidermal_growth_factor	36,59	EGF	61,64	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	-LSB- Effect of experimental diabetes on epidermal_growth_factor -LRB- EGF -RRB- receptors in the rat liver -RSB- .
3148118	0	epidermal_growth_factor	10,33	EGF	35,38	epidermal growth factor	EGF	1950	1950	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on a newly established head and neck squamous_carcinoma cell line .
315726	0	epidermal_growth_factor	18,41	EGF	43,46	epidermal growth factor	EGF	1950	1950	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of the epidermal_growth_factor -LRB- EGF -RRB- on the corneal epithelium in humans .
3489866	0	epidermal_growth_factor	10,33	EGF	35,38	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on experimental granulation tissue .
3490101	0	epidermal_growth_factor	10,33	EGF	35,38	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on blood flow and albumin extravasation in experimental granulation tissue .
3494514	0	epidermal_growth_factor	20,43	EGF	45,48	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	A trophic effect of epidermal_growth_factor -LRB- EGF -RRB- on rat colonic mucosa in organ culture .
3495790	0	epidermal_growth_factor	10,33	EGF	35,38	epidermal growth factor	EGF	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of epidermal_growth_factor -LRB- EGF -RRB- on -LSB- 3H -RSB- TdR incorporation into DNA in ad lib fed and fasted CD2F1 mice .
3498731	0	epidermal_growth_factor	24,47	EGF	49,52	epidermal growth factor	EGF	1950	1950	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Differential effects of epidermal_growth_factor -LRB- EGF -RRB- on cell locomotion and cell proliferation in a cloned human embryonal_carcinoma-derived cell line in vitro .
6126955	0	epidermal_growth_factor	14,37	EGF	39,42	epidermal growth factor	EGF	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of epidermal_growth_factor -LRB- EGF -RRB- on cell proliferation of the gastrointestinal_mucosa in rodents .
6131768	0	epidermal_growth_factor	11,34	EGF	36,39	epidermal growth factor	EGF	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of epidermal_growth_factor -LRB- EGF -RRB- on adult mouse small intestine in vivo and in organ culture .
7709468	0	epidermal_growth_factor	25,48	EGF	50,53	epidermal growth factor	EGF	1950	1950	Gene	Gene	correlation|nmod|START_ENTITY correlation|appos|END_ENTITY	-LSB- The correlation between epidermal_growth_factor -LRB- EGF -RRB- binding with receptors and the tyrosine phosphorylation of the EGF receptors in the plasma membrane and in the endosomes -RSB- .
7765094	0	epidermal_growth_factor	75,98	EGF	100,103	epidermal growth factor	EGF	1950	1950	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Proliferative response of fibroblasts expressing internalization-deficient epidermal_growth_factor -LRB- EGF -RRB- receptors is altered via differential EGF depletion effect .
7956924	0	epidermal_growth_factor	14,37	EGF	134,137	epidermal growth factor	EGF	1950	1950	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor -LRB- EGF -RRB- , its receptor , and related oncoprotein -LRB- erbB-2 -RRB- in human pituitary_tumors and response to EGF in vitro .
8031857	0	epidermal_growth_factor	21,44	EGF	46,49	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Short-term effect of epidermal_growth_factor -LRB- EGF -RRB- on sodium and glucose cotransport of isolated jejunal epithelial cells .
8258731	0	epidermal_growth_factor	11,34	EGF	36,39	epidermal growth factor	EGF	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of epidermal_growth_factor -LRB- EGF -RRB- on mouse sperm capacitation -RSB- .
8312873	0	epidermal_growth_factor	26,49	EGF	51,54	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Cytoprotective effects of epidermal_growth_factor -LRB- EGF -RRB- ointment containing nafamostat , a protease inhibitor , on tissue damage at burn sites in rats .
8369756	0	epidermal_growth_factor	20,43	EGF	45,48	epidermal growth factor	EGF	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Systemic effects of epidermal_growth_factor -LRB- EGF -RRB- ointment containing protease inhibitor or gelatin in rats with burns or open_wounds .
8925996	0	epidermal_growth_factor	18,41	EGF	43,46	epidermal growth factor	EGF	1950	1950	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	-LSB- Concentration of epidermal_growth_factor -LRB- EGF -RRB- in serum of women with endometrial_cancer -RSB- .
9787980	0	epidermal_growth_factor	8,31	EGF	33,36	epidermal growth factor	EGF	1950	1950	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of epidermal_growth_factor -LRB- EGF -RRB- in oesophageal mucosal integrity .
3872442	0	epidermal_growth_factor	83,106	Epidermal_growth_factor	0,23	epidermal growth factor	Epidermal growth factor	13645(Tax:10090)	13645(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Epidermal_growth_factor in mouse ocular tissue : effects of thyroxine and exogenous epidermal_growth_factor .
6290036	0	epidermal_growth_factor	48,71	Epidermal_growth_factor	0,23	epidermal growth factor	Epidermal growth factor	1950	1950	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Epidermal_growth_factor receptors and effect of epidermal_growth_factor on growth of human breast_cancer cells in long-term tissue culture .
9693119	0	epidermal_growth_factor	23,46	ErbB3	86,91	epidermal growth factor	ErbB3	1950	2065	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Signal transduction by epidermal_growth_factor and heregulin via the kinase-deficient ErbB3 protein .
11030146	0	epidermal_growth_factor	86,109	FKHR	75,79	epidermal growth factor	FKHR	1950	2308	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal_growth_factor treatment in human breast_cancer cells .
1645342	0	epidermal_growth_factor	51,74	GM3	24,27	epidermal growth factor	GM3	1950	110204(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Effects of gangliosides GM3 and De-N-acetyl_GM3 on epidermal_growth_factor receptor kinase activity and cell growth .
23426146	0	epidermal_growth_factor	47,70	GSTP1	0,5	epidermal growth factor	GSTP1	1950	2950	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	GSTP1 negatively regulates Stat3 activation in epidermal_growth_factor signaling .
12908818	0	epidermal_growth_factor	38,61	H-ras	0,5	epidermal growth factor	H-ras	1950	3265	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	H-ras dependent estrogenic effects of epidermal_growth_factor in the estrogen-independent breast_cancer cell line MDA-MB-231 .
11934884	0	epidermal_growth_factor	103,126	Herstatin	0,9	epidermal growth factor	Herstatin	1950	2064	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Herstatin , an autoinhibitor of the human epidermal_growth_factor receptor 2 tyrosine kinase , modulates epidermal_growth_factor signaling pathways resulting in growth_arrest .
8717450	0	epidermal_growth_factor	14,37	IGF-I	78,83	epidermal growth factor	IGF-I	25313(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	The effect of epidermal_growth_factor on circulating levels of free and total IGF-I and IGF-binding proteins in adult rats .
1940795	0	epidermal_growth_factor	55,78	IL-1_alpha	161,171	epidermal growth factor	IL-1 alpha	1950	3552	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Regulation of cytokine production in the human thymus : epidermal_growth_factor and transforming_growth_factor_alpha regulate mRNA levels of interleukin_1_alpha -LRB- IL-1_alpha -RRB- , IL-1_beta , and IL-6 in human thymic_epithelial cells at a post-transcriptional level .
1947790	0	epidermal_growth_factor	17,40	Insulin	0,7	epidermal growth factor	Insulin	100714471	100379579(Tax:10141)	Gene	Gene	growth|amod|START_ENTITY enhances|dobj|growth enhances|nsubj|END_ENTITY	Insulin enhances epidermal_growth_factor - and transforming_growth_factor-alpha-stimulated growth in primary cultures of guinea_pig gastric mucous epithelial cells .
8760113	0	epidermal_growth_factor	40,63	Insulin	0,7	epidermal growth factor	Insulin	100714471	100379579(Tax:10141)	Gene	Gene	effect|nmod|START_ENTITY potentiates|dobj|effect potentiates|nsubj|END_ENTITY	Insulin potentiates mitogenic effect of epidermal_growth_factor on cultured guinea_pig gastric mucous cells .
19913601	0	epidermal_growth_factor	55,78	Klotho	40,46	epidermal growth factor	Klotho	1950	9365	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional activation of the human Klotho gene by epidermal_growth_factor in HEK293 cells ; role of Egr-1 .
23696034	0	epidermal_growth_factor	114,137	Lipocalin-2	0,11	epidermal growth factor	Lipocalin-2	1950	3934	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Lipocalin-2 negatively modulates the epithelial-to-mesenchymal transition in hepatocellular_carcinoma through the epidermal_growth_factor -LRB- TGF-beta1 -RRB- / Lcn2/Twist1 pathway .
12640115	0	epidermal_growth_factor	104,127	MEK_kinase_2	0,12	epidermal growth factor	MEK kinase 2	1950	10746	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	MEK_kinase_2 and the adaptor protein Lad regulate extracellular_signal-regulated_kinase_5 activation by epidermal_growth_factor via Src .
12851697	0	epidermal_growth_factor	82,105	MMP-7	110,115	epidermal growth factor	MMP-7	1950	4316	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Difference in responsiveness of human esophageal_squamous_cell_carcinoma lines to epidermal_growth_factor for MMP-7 expression .
9683296	0	epidermal_growth_factor	41,64	Matrix_metalloproteinase-1	0,26	epidermal growth factor	Matrix metalloproteinase-1	1950	4312	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Matrix_metalloproteinase-1 is induced by epidermal_growth_factor in human bladder_tumour cell lines and is detectable in urine of patients with bladder_tumours .
11942325	0	epidermal_growth_factor	50,73	PC3	155,158	epidermal growth factor	PC3	1950	57332	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	The role of superoxide anion in the regulation of epidermal_growth_factor or the expression and proliferation of its receptor in prostate_cancer cell line PC3 .
8290389	0	epidermal_growth_factor	10,33	PC3	63,66	epidermal growth factor	PC3	1950	57332	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of epidermal_growth_factor on prostate_cancer cell line PC3 growth and invasion .
9287352	0	epidermal_growth_factor	72,95	SHP-1	63,68	epidermal growth factor	SHP-1	1950	5777	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Positive effects of SH2 domain-containing tyrosine phosphatase SHP-1 on epidermal_growth_factor - and interferon-gamma-stimulated activation of STAT transcription factors in HeLa cells .
15133037	0	epidermal_growth_factor	104,127	SHP-2	74,79	epidermal growth factor	SHP-2	1950	5781	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	The major_vault_protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal_growth_factor signaling .
16205632	0	epidermal_growth_factor	79,102	STAT3	15,20	epidermal growth factor	STAT3	1950	6774	Gene	Gene	characteristics|amod|START_ENTITY activation|nmod|characteristics activation|nsubj|Requirement Requirement|nmod|END_ENTITY	Requirement of STAT3 activation for maximal collagenase-1 -LRB- MMP-1 -RRB- induction by epidermal_growth_factor and malignant characteristics in T24 bladder_cancer cells .
25175149	0	epidermal_growth_factor	40,63	STAT3	117,122	epidermal growth factor	STAT3	1950	6774	Gene	Gene	response|nmod|START_ENTITY fibronectin|nmod|response Induction|nmod|fibronectin suppressed|nsubjpass|Induction suppressed|nmod|inhibition inhibition|nmod|END_ENTITY	Induction of fibronectin in response to epidermal_growth_factor is suppressed by silibinin through the inhibition of STAT3 in triple negative breast_cancer cells .
11751923	0	epidermal_growth_factor	42,65	STAT5b	20,26	epidermal growth factor	STAT5b	1950	6777	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Novel activation of STAT5b in response to epidermal_growth_factor .
14963038	0	epidermal_growth_factor	15,38	Stat3	57,62	epidermal growth factor	Stat3	1950	6774	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Pyk2 amplifies epidermal_growth_factor and c-Src-induced Stat3 activation .
23426146	0	epidermal_growth_factor	47,70	Stat3	27,32	epidermal growth factor	Stat3	1950	6774	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	GSTP1 negatively regulates Stat3 activation in epidermal_growth_factor signaling .
8140422	0	epidermal_growth_factor	81,104	Stat3	0,5	epidermal growth factor	Stat3	1950	6774	Gene	Gene	activated|nmod|START_ENTITY member|acl|activated END_ENTITY|dep|member	Stat3 : a STAT family member activated by tyrosine phosphorylation in response to epidermal_growth_factor and interleukin-6 .
8263129	0	epidermal_growth_factor	138,161	TGF-alpha	168,177	epidermal growth factor	TGF-alpha	1950	7039	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	Androgens regulate proliferation of human_prostate_cancer cells in culture by increasing transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- and epidermal_growth_factor -LRB- EGF -RRB- / TGF-alpha receptor .
16428382	0	epidermal_growth_factor	25,48	TGF-beta	85,93	epidermal growth factor	TGF-beta	1950	7040	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Novel permissive role of epidermal_growth_factor in transforming_growth_factor_beta -LRB- TGF-beta -RRB- signaling and growth suppression .
7559800	0	epidermal_growth_factor	46,69	Tenascin-C	0,10	epidermal growth factor	Tenascin-C	1950	3371	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Tenascin-C induction by the diffusible factor epidermal_growth_factor in stromal-epithelial interactions .
2422759	0	epidermal_growth_factor	73,96	Transforming_growth_factor-alpha	0,32	epidermal growth factor	Transforming growth factor-alpha	1950	7124	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|dep|mediator	Transforming_growth_factor-alpha : a more potent angiogenic mediator than epidermal_growth_factor .
23982810	0	epidermal_growth_factor	135,158	VEGFR1	173,179	epidermal growth factor	VEGFR1	13645(Tax:10090)	14254(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Vascular_endothelial_growth_factor_receptor_1 signaling facilitates gastric ulcer_healing and angiogenesis through the upregulation of epidermal_growth_factor expression on VEGFR1 + CXCR4 + cells recruited from bone marrow .
11938800	0	epidermal_growth_factor	14,37	VIP	41,44	epidermal growth factor	VIP	1950	7432	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	-LSB- Affection of epidermal_growth_factor on VIP secretion and VIPR expression in airway epithelial cells -RSB- .
14527519	0	epidermal_growth_factor	143,166	ZO-1	126,130	epidermal growth factor	ZO-1	521832(Tax:9913)	407102(Tax:9913)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Infection of human and bovine epithelial cells with Cryptosporidium andersoni induces apoptosis and disrupts tight junctional ZO-1 : effects of epidermal_growth_factor .
24813021	0	epidermal_growth_factor	18,41	amphiregulin	108,120	epidermal growth factor	amphiregulin	1950	374	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|appos|END_ENTITY	The expression of epidermal_growth_factor receptors and their ligands -LRB- epidermal_growth_factor , neuregulin , amphiregulin -RRB- in the bitch uterus during the estrus cycle .
8912815	0	epidermal_growth_factor	35,58	androgen_receptor	14,31	epidermal growth factor	androgen receptor	13645(Tax:10090)	11835(Tax:10090)	Gene	Gene	modulation|compound|START_ENTITY Activation|nmod|modulation Activation|nmod|END_ENTITY	Activation of androgen_receptor in epidermal_growth_factor modulation of fetal mouse sexual differentiation .
3263965	0	epidermal_growth_factor	113,136	bradykinin	156,166	epidermal growth factor	bradykinin	1950	3827	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	An increase in intracellular free Ca2 + associated with serum-free growth stimulation of Swiss 3T3 fibroblasts by epidermal_growth_factor in the presence of bradykinin .
2430281	0	epidermal_growth_factor	37,60	c-fos	13,18	epidermal growth factor	c-fos	1950	2353	Gene	Gene	ionophore|compound|START_ENTITY mRNA|nmod|ionophore mRNA|amod|END_ENTITY	Induction of c-fos and c-myc mRNA by epidermal_growth_factor or calcium ionophore is cAMP dependent .
3119989	0	epidermal_growth_factor	63,86	c-fos	0,5	epidermal growth factor	c-fos	1950	2353	Gene	Gene	sequence|nmod|START_ENTITY sequence|nsubj|END_ENTITY	c-fos sequence necessary for basal expression and induction by epidermal_growth_factor , 12-O-tetradecanoyl_phorbol-13-acetate and the calcium ionophore .
3497813	0	epidermal_growth_factor	11,34	c-fos	73,78	epidermal growth factor	c-fos	1950	2353	Gene	Gene	factor|compound|START_ENTITY factor|nmod|levels levels|amod|END_ENTITY	Effects of epidermal_growth_factor and platelet-derived growth factor on c-fos and c-myc mRNA levels in normal human fibroblasts .
8524316	0	epidermal_growth_factor	81,104	c-fos	56,61	epidermal growth factor	STAT1	1950	6772	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal_growth_factor .
15958574	0	epidermal_growth_factor	93,116	colony-stimulating_factor-1	65,92	epidermal growth factor	colony-stimulating factor-1	1950	1435	Gene	Gene	loop|compound|START_ENTITY loop|amod|END_ENTITY	Macrophages promote the invasion of breast_carcinoma cells via a colony-stimulating_factor-1 / epidermal_growth_factor paracrine loop .
1692217	0	epidermal_growth_factor	48,71	elastin	27,34	epidermal growth factor	elastin	408035(Tax:9031)	396441(Tax:9031)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Preferential inhibition of elastin synthesis by epidermal_growth_factor in chick aortic smooth muscle cells .
6274775	0	epidermal_growth_factor	27,50	epidermal_growth_factor	63,86	epidermal growth factor	epidermal growth factor	397083(Tax:9823)	397083(Tax:9823)	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	-LSB- The experimental study of epidermal_growth_factor - effects of epidermal_growth_factor on the cyclic nucleotide system and protein phosphorylation in pig epidermis - -LRB- author 's transl -RRB- -RSB- .
6274775	0	epidermal_growth_factor	63,86	epidermal_growth_factor	27,50	epidermal growth factor	epidermal growth factor	397083(Tax:9823)	397083(Tax:9823)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	-LSB- The experimental study of epidermal_growth_factor - effects of epidermal_growth_factor on the cyclic nucleotide system and protein phosphorylation in pig epidermis - -LRB- author 's transl -RRB- -RSB- .
8244269	0	epidermal_growth_factor	12,35	epidermal_growth_factor	50,73	epidermal growth factor	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Handling of epidermal_growth_factor and number of epidermal_growth_factor receptors are changed in aged male rats .
8244269	0	epidermal_growth_factor	50,73	epidermal_growth_factor	12,35	epidermal growth factor	epidermal growth factor	25313(Tax:10116)	25313(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Handling of epidermal_growth_factor and number of epidermal_growth_factor receptors are changed in aged male rats .
10770635	0	epidermal_growth_factor	20,43	epidermal_growth_factor_receptor	119,151	epidermal growth factor	epidermal growth factor receptor	13645(Tax:10090)	13649(Tax:10090)	Gene	Gene	Gene|nmod|START_ENTITY polyplex|dep|Gene polyplex|nmod|lines lines|acl|expressing expressing|dobj|levels levels|nmod|END_ENTITY	Gene delivery by an epidermal_growth_factor / DNA polyplex to small_cell_lung_cancer cell lines expressing low levels of epidermal_growth_factor_receptor .
11513601	0	epidermal_growth_factor	92,115	epidermal_growth_factor_receptor	123,155	epidermal growth factor	epidermal growth factor receptor	13645(Tax:10090)	13649(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Real-time kinetics of ligand/cell surface receptor interactions in living cells : binding of epidermal_growth_factor to the epidermal_growth_factor_receptor .
11746830	0	epidermal_growth_factor	32,55	epidermal_growth_factor_receptor	110,142	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	START_ENTITY|nmod|lines lines|acl|overexpressing overexpressing|dobj|owing owing|compound|END_ENTITY	Decreased mitogenic response to epidermal_growth_factor in human squamous_cell_carcinoma lines overexpressing epidermal_growth_factor_receptor owing to limiting amounts of the adaptor protein Grb2 : rescue by retinoic_acid treatment .
11889128	0	epidermal_growth_factor	18,41	epidermal_growth_factor_receptor	51,83	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	recruits|compound|START_ENTITY END_ENTITY|nsubj|recruits	Elastase-released epidermal_growth_factor recruits epidermal_growth_factor_receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts .
14690686	0	epidermal_growth_factor	60,83	epidermal_growth_factor_receptor	155,187	epidermal growth factor	epidermal growth factor receptor	13645(Tax:10090)	13649(Tax:10090)	Gene	Gene	Preparation|nmod|START_ENTITY Preparation|dep|application application|nmod|END_ENTITY	Preparation and characterization of Alexa_Fluor_594-labeled epidermal_growth_factor for fluorescence resonance energy transfer studies : application to the epidermal_growth_factor_receptor .
1691502	0	epidermal_growth_factor	74,97	epidermal_growth_factor_receptor	6,38	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	cross-linked|xcomp|START_ENTITY cross-linked|nsubj|residue residue|compound|END_ENTITY	Human epidermal_growth_factor_receptor residue covalently cross-linked to epidermal_growth_factor .
1847663	0	epidermal_growth_factor	28,51	epidermal_growth_factor_receptor	95,127	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Cellular growth response to epidermal_growth_factor in colon_carcinoma cells with an amplified epidermal_growth_factor_receptor derived from a familial_adenomatous_polyposis patient .
20187444	0	epidermal_growth_factor	64,87	epidermal_growth_factor_receptor	105,137	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of topical external administration of recombinant human epidermal_growth_factor on expression of epidermal_growth_factor_receptor and its mRNA in scald wound of diabetes_mellitus rat -RSB- .
2434521	0	epidermal_growth_factor	52,75	epidermal_growth_factor_receptor	129,161	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	function|nmod|START_ENTITY function|parataxis|detected detected|dobj|levels levels|compound|END_ENTITY	Induction of differentiated trophoblast function by epidermal_growth_factor : relation of immunohistochemically detected cellular epidermal_growth_factor_receptor levels .
25416211	0	epidermal_growth_factor	70,93	epidermal_growth_factor_receptor	15,47	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of epidermal_growth_factor_receptor and concentrations of epidermal_growth_factor and melatonin in endometrial_carcinoma -RSB- .
3015918	0	epidermal_growth_factor	45,68	epidermal_growth_factor_receptor	80,112	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Effects of protein kinase C activation after epidermal_growth_factor binding on epidermal_growth_factor_receptor phosphorylation .
3324824	0	epidermal_growth_factor	112,135	epidermal_growth_factor_receptor	26,58	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	using|dobj|START_ENTITY detection|acl|using detection|nmod|END_ENTITY	Western blot detection of epidermal_growth_factor_receptor from plasmalemma of culture cells using 125I-labeled epidermal_growth_factor .
6208480	0	epidermal_growth_factor	11,34	epidermal_growth_factor_receptor	97,129	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal_growth_factor_receptor in normal human fibroblasts .
8608180	0	epidermal_growth_factor	80,103	epidermal_growth_factor_receptor	26,58	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	labeled|dobj|START_ENTITY 111In|acl|labeled radioligand|dep|111In radioligand|nmod|END_ENTITY	A new radioligand for the epidermal_growth_factor_receptor : 111In labeled human epidermal_growth_factor derivatized with a bifunctional metal-chelating peptide .
8827569	0	epidermal_growth_factor	10,33	epidermal_growth_factor_receptor	86,118	epidermal growth factor	epidermal growth factor receptor	25313(Tax:10116)	24329(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY amino_acid|nsubj|Effect amino_acid|dobj|transport transport|nmod|expression expression|compound|END_ENTITY	Effect of epidermal_growth_factor on placental amino_acid transport and regulation of epidermal_growth_factor_receptor expression of hepatocyte in rat .
9398212	0	epidermal_growth_factor	105,128	epidermal_growth_factor_receptor	54,86	epidermal growth factor	epidermal growth factor receptor	1950	1956	Gene	Gene	absence|nmod|START_ENTITY Persistence|nmod|absence Persistence|nmod|END_ENTITY	Persistence of dimerization and enzymatic activity of epidermal_growth_factor_receptor in the absence of epidermal_growth_factor .
2566164	0	epidermal_growth_factor	38,61	gastrin	18,25	epidermal growth factor	gastrin	1950	2520	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the gastrin promoter by epidermal_growth_factor and neuropeptides .
2809491	0	epidermal_growth_factor	79,102	growth_hormone	33,47	epidermal growth factor	growth hormone	1950	81668(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY number|nmod|receptors controls|dobj|number controls|nsubj|rhythm rhythm|nmod|END_ENTITY	Differential secretory rhythm of growth_hormone controls the number of hepatic epidermal_growth_factor receptors in the rat .
6609514	0	epidermal_growth_factor	56,79	growth_hormone	133,147	epidermal growth factor	growth hormone	1950	2688	Gene	Gene	pregnancy|nmod|START_ENTITY stages|nmod|pregnancy ewes|nmod|stages Treatment|nmod|ewes Treatment|dep|effects effects|nmod|growth growth|nmod|lactogen lactogen|compound|END_ENTITY	Treatment of ewes at different stages of pregnancy with epidermal_growth_factor : effects on wool growth and plasma concentrations of growth_hormone , prolactin , placental lactogen and thyroxine and on foetal development .
10537052	0	epidermal_growth_factor	53,76	growth_inhibitory_factor	14,38	epidermal growth factor	growth inhibitory factor	25313(Tax:10116)	117038(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of growth_inhibitory_factor expression by epidermal_growth_factor and interleukin-1beta in cultured rat astrocytes .
2206955	0	epidermal_growth_factor	8,31	hEGF	33,37	epidermal growth factor	hEGF	1950	1950	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Urinary epidermal_growth_factor -LRB- hEGF -RRB- levels in patients with carcinomas of the breast , colon and rectum .
2233130	0	epidermal_growth_factor	16,39	hEGF	41,45	epidermal growth factor	hEGF	1950	1950	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of human epidermal_growth_factor -LRB- hEGF -RRB- on splanchnic circulation in dogs .
7534491	0	epidermal_growth_factor	67,90	hepatocyte_growth_factor	13,37	epidermal growth factor	hepatocyte growth factor	1950	24446(Tax:10116)	Gene	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|nsubj|Induction Induction|nmod|END_ENTITY	Induction of hepatocyte_growth_factor in human skin fibroblasts by epidermal_growth_factor , platelet-derived growth factor and fibroblast growth factor .
3062579	0	epidermal_growth_factor	50,73	hnRNP_A1	14,22	epidermal growth factor	hnRNP A1	25313(Tax:10116)	29578(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of hnRNP_A1 protein gene expression by epidermal_growth_factor in Rat-1 cells .
19143943	0	epidermal_growth_factor	18,41	interleukin-6	43,56	epidermal growth factor	interleukin-6	1950	3569	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Urinary levels of epidermal_growth_factor , interleukin-6 and monocyte_chemoattractant_protein-1 may act as predictor markers of renal function outcome in immunoglobulin A nephropathy .
12954631	0	epidermal_growth_factor	62,85	keratin_16	32,42	epidermal growth factor	keratin 16	1950	3868	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of disease-associated keratin_16 gene expression by epidermal_growth_factor is regulated through cooperation of transcription factors Sp1 and c-Jun .
16214953	0	epidermal_growth_factor	65,88	keratin_16	139,149	epidermal growth factor	keratin 16	1950	3868	Gene	Gene	signaling|nmod|START_ENTITY kinase|acl|signaling Activation|nmod|kinase mediates|nsubj|Activation mediates|dobj|activation activation|nmod|expression expression|amod|END_ENTITY	Activation of extracellular signal-regulated kinase signaling by epidermal_growth_factor mediates c-Jun activation and p300 recruitment in keratin_16 gene expression .
8776733	0	epidermal_growth_factor	58,81	lactoferrin	38,49	epidermal growth factor	lactoferrin	13645(Tax:10090)	17002(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Promoter-specific activation of mouse lactoferrin gene by epidermal_growth_factor involves two adjacent regulatory elements .
1672042	0	epidermal_growth_factor	11,34	luteinizing_hormone-releasing_hormone	52,89	epidermal growth factor	luteinizing hormone-releasing hormone	1950	2796	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor and analogues of luteinizing_hormone-releasing_hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors .
22041445	0	epidermal_growth_factor	11,34	matrix_metalloproteinase-9	56,82	epidermal growth factor	matrix metalloproteinase-9	1950	4318	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of epidermal_growth_factor on the expression of matrix_metalloproteinase-9 and the signalling pathways involved in the trophoblast cell line JEG-3 -RSB- .
12618892	0	epidermal_growth_factor	68,91	neuropilin-1	13,25	epidermal growth factor	neuropilin-1	1950	8829	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of neuropilin-1 and vascular_endothelial_growth_factor by epidermal_growth_factor in human gastric_cancer cells .
8387505	1	epidermal_growth_factor	238,261	neurotrophic_factor	170,189	epidermal growth factor	neurotrophic factor	25313(Tax:10116)	81737(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Distinct effects of the neurotrophic_factor , nerve_growth_factor , and the mitogenic factor , epidermal_growth_factor .
1611658	0	epidermal_growth_factor	10,33	ornithine_decarboxylase	37,60	epidermal growth factor	ornithine decarboxylase	25313(Tax:10116)	24609(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of epidermal_growth_factor on ornithine_decarboxylase activity and urea synthesis in isolated rat hepatocytes .
2495753	0	epidermal_growth_factor	10,33	ornithine_decarboxylase	37,60	epidermal growth factor	ornithine decarboxylase	1950	4953	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of epidermal_growth_factor on ornithine_decarboxylase activity in A431 cells .
8353159	0	epidermal_growth_factor	11,34	ornithine_decarboxylase	38,61	epidermal growth factor	ornithine decarboxylase	25313(Tax:10116)	24609(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of epidermal_growth_factor on ornithine_decarboxylase activity and DNA synthesis in rats during the perinatal period .
8912706	0	epidermal_growth_factor	41,64	ornithine_decarboxylase	121,144	epidermal growth factor	ornithine decarboxylase	1950	4953	Gene	Gene	signalling|compound|START_ENTITY inhibits|dobj|signalling inhibits|advcl|leading leading|nmod|activity activity|compound|END_ENTITY	Phorbol_12-myristate_13-acetate inhibits epidermal_growth_factor signalling in human keratinocytes , leading to decreased ornithine_decarboxylase activity .
19951549	0	epidermal_growth_factor	85,108	peroxisome_proliferator-activated_receptor_beta	9,56	epidermal growth factor	peroxisome proliferator-activated receptor beta	1950	5467	Gene	Gene	effect|nmod|START_ENTITY Role|nmod|effect Role|nmod|END_ENTITY	-LSB- Role of peroxisome_proliferator-activated_receptor_beta in the inhibitory effect of epidermal_growth_factor on apoptosis of HaCaT -RSB- .
1826422	0	epidermal_growth_factor	43,66	phospholipase_A2	14,30	epidermal growth factor	phospholipase A2	1950	151056	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modulation of phospholipase_A2 activity by epidermal_growth_factor -LRB- EGF -RRB- in CHO cells transfected with human EGF_receptor .
11303186	0	epidermal_growth_factor	77,100	plasminogen_activator_inhibitor_1	14,47	epidermal growth factor	plasminogen activator inhibitor 1	1950	5054	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of plasminogen_activator_inhibitor_1 expression by interaction of epidermal_growth_factor with progestin during decidualization of human endometrial stromal cells .
2783381	0	epidermal_growth_factor	84,107	progesterone_receptor	33,54	epidermal growth factor	progesterone receptor	1950	5241	Gene	Gene	implication|amod|START_ENTITY Decrease|nmod|implication Decrease|nmod|production production|compound|END_ENTITY	Decrease in estradiol-stimulated progesterone_receptor production in MCF-7 cells by epidermal_growth_factor and possible clinical implication for paracrine-regulated breast_cancer growth .
2783569	0	epidermal_growth_factor	51,74	progesterone_receptor	95,116	epidermal growth factor	progesterone receptor	1950	5241	Gene	Gene	effect|nmod|START_ENTITY antagonize|dobj|effect antagonize|nmod|induction induction|nmod|END_ENTITY	Antiestrogens antagonize the stimulatory effect of epidermal_growth_factor on the induction of progesterone_receptor in fetal uterine cells in culture .
6328483	0	epidermal_growth_factor	101,124	prolactin	157,166	epidermal growth factor	prolactin	25313(Tax:10116)	24683(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Polypeptide hormone regulation of gene transcription : specific 5 ' genomic sequences are required for epidermal_growth_factor and phorbol_ester regulation of prolactin gene expression .
8950780	0	epidermal_growth_factor	104,127	protein_C	153,162	epidermal growth factor	protein C	1950	5624	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Functional consequences of mutations in amino_acid residues that stabilize calcium binding to the first epidermal_growth_factor homology domain of human protein_C .
7924740	0	epidermal_growth_factor	52,75	secretin	10,18	epidermal growth factor	secretin	25313(Tax:10116)	24769(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of secretin and somatostatin on secretion of epidermal_growth_factor from Brunner 's glands in the rat .
16414307	0	epidermal_growth_factor	4,27	sphingosine_kinase-1	39,59	epidermal growth factor	sphingosine kinase-1	1950	8877	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|expression expression|amod|END_ENTITY	The epidermal_growth_factor stimulates sphingosine_kinase-1 expression and activity in the human mammary carcinoma cell line MCF7 .
15951439	0	epidermal_growth_factor	54,77	sphingosine_kinase_2	8,28	epidermal growth factor	sphingosine kinase 2	1950	56848	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of sphingosine_kinase_2 in cell migration toward epidermal_growth_factor .
2536746	1	epidermal_growth_factor	47,70	thrombomodulin	100,114	epidermal growth factor	thrombomodulin	1950	7056	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Residues 310-486 from the epidermal_growth_factor precursor homology domain of thrombomodulin will accelerate protein C activation .
15272014	0	epidermal_growth_factor	69,92	tissue_transglutaminase	16,39	epidermal growth factor	tissue transglutaminase	1950	7052	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Augmentation of tissue_transglutaminase expression and activation by epidermal_growth_factor inhibit doxorubicin-induced apoptosis in human breast_cancer cells .
12935417	0	epidermal_growth_factor	97,120	transferrin	11,22	epidermal growth factor	transferrin	1950	7018	Gene	Gene	comparison|nmod|START_ENTITY Effects|dep|comparison Effects|nmod|END_ENTITY	Effects of transferrin on the growth and proliferation of porcine hepatocytes : a comparison with epidermal_growth_factor and nicotinamide .
2168868	0	epidermal_growth_factor	67,90	transforming_growth_factor-alpha	98,130	epidermal growth factor	transforming growth factor-alpha	1950	7124	Gene	Gene	Induction|nmod|START_ENTITY END_ENTITY|nsubj|Induction	Induction of growth factor-receptor and metalloproteinase genes by epidermal_growth_factor and/or transforming_growth_factor-alpha in human gastric_carcinoma cell line MKN-28 .
8625491	0	epidermal_growth_factor	97,120	transforming_growth_factor-alpha	18,50	epidermal growth factor	transforming growth factor-alpha	1950	7124	Gene	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of transforming_growth_factor-alpha and epidermal_growth_factor_receptor , but not epidermal_growth_factor , in exocrine pancreatic_tumours in hamsters .
2433030	0	epidermal_growth_factor	74,97	transforming_growth_factor_alpha	13,45	epidermal growth factor	transforming growth factor alpha	1950	7124	Gene	Gene	Elevation|nmod|START_ENTITY Elevation|nmod|END_ENTITY	Elevation of transforming_growth_factor_alpha and its relationship to the epidermal_growth_factor and alpha-fetoprotein levels in patients with hepatocellular_carcinoma .
9030534	0	epidermal_growth_factor	114,137	transforming_growth_factor_beta1	171,203	epidermal growth factor	transforming growth factor beta1	13645(Tax:10090)	21803(Tax:10090)	Gene	Gene	hormone|dep|START_ENTITY hormone|dep|END_ENTITY	Hyaluronan synthesis by mouse cumulus cells is regulated by interactions between follicle-stimulating hormone -LRB- or epidermal_growth_factor -RRB- and a soluble oocyte factor -LRB- or transforming_growth_factor_beta1 -RRB- .
12218613	0	epidermal_growth_factor	14,37	tumor_necrosis_factor-alpha	39,66	epidermal growth factor	tumor necrosis factor-alpha	1950	7124	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of epidermal_growth_factor , tumor_necrosis_factor-alpha , and interleukin-1alpha in chronic_otitis_media with or without cholesteatoma .
12667326	0	epidermal_growth_factor	21,44	vascular_endothelial_growth_factor	67,101	epidermal growth factor	vascular endothelial growth factor	1950	7422	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	-LSB- Correlation between epidermal_growth_factor and overexpression of vascular_endothelial_growth_factor in hepatocellular_carcinoma -RSB- .
12910515	0	epidermal_growth_factor	99,122	vascular_endothelial_growth_factor	39,73	epidermal growth factor	vascular endothelial growth factor	1950	7422	Gene	Gene	neuropilin-1|nmod|START_ENTITY Expression|amod|neuropilin-1 Expression|nmod|receptor receptor|compound|END_ENTITY	Expression and regulation of the novel vascular_endothelial_growth_factor receptor neuropilin-1 by epidermal_growth_factor in human pancreatic_carcinoma .
15367698	0	epidermal_growth_factor	113,136	vascular_endothelial_growth_factor	10,44	epidermal growth factor	vascular endothelial growth factor	1950	7422	Gene	Gene	kinase|compound|START_ENTITY activity|nmod|kinase inhibitor|nmod|activity inhibitor|compound|END_ENTITY	ZD6474 , a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor with additional activity against epidermal_growth_factor receptor tyrosine kinase , inhibits orthotopic growth and angiogenesis of gastric_cancer .
16019439	0	epidermal_growth_factor	14,37	vascular_endothelial_growth_factor	55,89	epidermal growth factor	vascular endothelial growth factor	1950	7422	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of epidermal_growth_factor on production of vascular_endothelial_growth_factor by amnion-derived -LRB- WISH -RRB- cells .
23495770	0	epidermal_growth_factor	105,128	vascular_endothelial_growth_factor	46,80	epidermal growth factor	vascular endothelial growth factor	1950	7422	Gene	Gene	START_ENTITY|nsubj|cells cells|appos|IL-8 IL-8|appos|END_ENTITY	Regulatory T cells , interleukin _ -LRB- IL -RRB- -6 , IL-8 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , CXCL10 , CXCL11 , epidermal_growth_factor -LRB- EGF -RRB- and hepatocyte_growth_factor -LRB- HGF -RRB- as surrogate markers of host immunity in patients with renal_cell_carcinoma .
15634274	0	epidermal_growth_factor-like	10,38	factor_Xa_and_factor_IXa	50,74	epidermal growth factor-like	factor Xa and factor IXa	85476	2159	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	The first epidermal_growth_factor-like domains of factor_Xa_and_factor_IXa are important for the activation of the factor VII -- tissue factor complex .
18322824	0	epidermal_growth_factor-like_repeat	3,38	Del1	42,46	epidermal growth factor-like repeat	Del1	1738	10085	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	An epidermal_growth_factor-like_repeat of Del1 protein increases the efficiency of gene transfer in vitro .
19112101	0	epidermal_growth_factor-receptor	81,113	IL-8	43,47	epidermal growth factor-receptor	IL-8	1956	3576	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal_growth_factor-receptor in human bronchial epithelial cells .
15327841	0	epidermal_growth_factor-receptor_related_protein	14,62	ERRP	64,68	epidermal growth factor-receptor related protein	ERRP	64285	64285	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of epidermal_growth_factor-receptor_related_protein -LRB- ERRP -RRB- in human colorectal_carcinogenesis .
16840716	0	epidermal_growth_factor_receptor	16,48	ADAM17	0,6	epidermal growth factor receptor	ADAM17	1956	6868	Gene	Gene	transactivation|compound|START_ENTITY mediates|dobj|transactivation mediates|nsubj|END_ENTITY	ADAM17 mediates epidermal_growth_factor_receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin_II .
17227756	0	epidermal_growth_factor_receptor	50,82	ADAM17	38,44	epidermal growth factor receptor	ADAM17	1956	6868	Gene	Gene	activation|compound|START_ENTITY up-regulation|nmod|activation up-regulation|nmod|END_ENTITY	Post-transcriptional up-regulation of ADAM17 upon epidermal_growth_factor_receptor activation and in breast_tumors .
20551051	0	epidermal_growth_factor_receptor	17,49	ADAM17	0,6	epidermal growth factor receptor	ADAM17	1956	6868	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	ADAM17 regulates epidermal_growth_factor_receptor expression through the activation of Notch1 in non-small_cell_lung_cancer .
23850346	0	epidermal_growth_factor_receptor	53,85	ADAM17	146,152	epidermal growth factor receptor	ADAM17	1956	6868	Gene	Gene	activation|compound|START_ENTITY promotes|dobj|activation promotes|nmod|expression expression|compound|END_ENTITY	Upregulation of Nox4 promotes angiotensin_II-induced epidermal_growth_factor_receptor activation and subsequent cardiac_hypertrophy by increasing ADAM17 expression .
24412389	0	epidermal_growth_factor_receptor	57,89	ADAM17	40,46	epidermal growth factor receptor	ADAM17	1956	6868	Gene	Gene	transactivation|compound|START_ENTITY mediates|dobj|transactivation mediates|nsubj|A_disintegrin_and_metalloproteinase_17 A_disintegrin_and_metalloproteinase_17|appos|END_ENTITY	A_disintegrin_and_metalloproteinase_17 -LRB- ADAM17 -RRB- mediates epidermal_growth_factor_receptor transactivation by angiotensin_II on hepatic stellate cells .
20959404	0	epidermal_growth_factor_receptor	40,72	AKT	103,106	epidermal growth factor receptor	AKT	1956	207	Gene	Gene	oncoprotein|nmod|START_ENTITY upregulated|nmod|oncoprotein phosphatidylinositol_3-kinase|dep|upregulated phosphatidylinositol_3-kinase|appos|confers confers|nsubj|END_ENTITY	cIAP2 upregulated by E6 oncoprotein via epidermal_growth_factor_receptor / phosphatidylinositol_3-kinase / AKT pathway confers resistance to cisplatin in human_papillomavirus_16 / 18-infected lung_cancer .
24412389	0	epidermal_growth_factor_receptor	57,89	A_disintegrin_and_metalloproteinase_17	0,38	epidermal growth factor receptor	A disintegrin and metalloproteinase 17	1956	6868	Gene	Gene	transactivation|compound|START_ENTITY mediates|dobj|transactivation mediates|nsubj|END_ENTITY	A_disintegrin_and_metalloproteinase_17 -LRB- ADAM17 -RRB- mediates epidermal_growth_factor_receptor transactivation by angiotensin_II on hepatic stellate cells .
12472891	0	epidermal_growth_factor_receptor	48,80	Akt	36,39	epidermal growth factor receptor	Akt	13649(Tax:10090)	11651(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Nicotine-induced phosphorylation of Akt through epidermal_growth_factor_receptor and Src in PC12h cells .
16055672	0	epidermal_growth_factor_receptor	21,53	Akt	57,60	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	paths|nmod|START_ENTITY paths|nmod|END_ENTITY	Alternate paths from epidermal_growth_factor_receptor to Akt in malignant versus nontransformed lung epithelial cells : ErbB3 versus Gab1 .
16675591	0	epidermal_growth_factor_receptor	140,172	Akt	87,90	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	activation|compound|START_ENTITY dependent|nmod|activation dependent|nsubj|activation activation|compound|END_ENTITY	Gefitinib inhibits the growth and invasion of urothelial_carcinoma cell lines in which Akt and MAPK activation is dependent on constitutive epidermal_growth_factor_receptor activation .
16928826	0	epidermal_growth_factor_receptor	27,59	Akt	16,19	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	erlotinib|compound|START_ENTITY END_ENTITY|nmod|erlotinib	Inactivation of Akt by the epidermal_growth_factor_receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal_tumor cell lines and contributes to erlotinib sensitivity .
17349623	0	epidermal_growth_factor_receptor	52,84	Akt	36,39	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	pathway|compound|START_ENTITY activates|nmod|pathway activates|dobj|END_ENTITY	Gastrin-releasing_peptide activates Akt through the epidermal_growth_factor_receptor pathway and abrogates the effect of gefitinib .
19153210	0	epidermal_growth_factor_receptor	91,123	Akt	21,24	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	transactivation|compound|START_ENTITY signalling|nmod|transactivation END_ENTITY|acl|signalling	Obestatin stimulates Akt signalling in gastric_cancer cells through beta-arrestin-mediated epidermal_growth_factor_receptor transactivation .
20103665	0	epidermal_growth_factor_receptor	22,54	Akt	116,119	epidermal growth factor receptor	Akt	13649(Tax:10090)	11651(Tax:10090)	Gene	Gene	Radiosensitization|nmod|START_ENTITY Radiosensitization|parataxis|mediated mediated|nmod|inhibition inhibition|nmod|END_ENTITY	Radiosensitization of epidermal_growth_factor_receptor / HER2-positive pancreatic_cancer is mediated by inhibition of Akt independent of ras mutational status .
20506627	0	epidermal_growth_factor_receptor	79,111	Akt	53,56	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Cobalt_chloride stimulates phosphoinositide_3-kinase / Akt signaling through the epidermal_growth_factor_receptor in oral_squamous_cell_carcinoma .
21040950	0	epidermal_growth_factor_receptor	48,80	Akt	81,84	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	Paradigm|nmod|START_ENTITY Paradigm|dep|END_ENTITY	Paradigm of kinase-driven pathway downstream of epidermal_growth_factor_receptor / Akt in human lung_carcinomas .
21057220	0	epidermal_growth_factor_receptor	21,53	Akt	105,108	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	mutations|compound|START_ENTITY effect|nmod|mutations effect|nmod|END_ENTITY	Prognostic effect of epidermal_growth_factor_receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian_cancer .
25338626	0	epidermal_growth_factor_receptor	59,91	Akt	94,97	epidermal growth factor receptor	Akt	13649(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|dep|bortezomib bortezomib|compound|END_ENTITY	Reactive oxygen species - mediated activation of the Src - epidermal_growth_factor_receptor - Akt signaling cascade prevents bortezomib - induced apoptosis in hepatocellular_carcinoma cells .
26617770	0	epidermal_growth_factor_receptor	123,155	Akt	82,85	epidermal growth factor receptor	Akt	1956	207	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nmod|END_ENTITY	MicroRNA-133b inhibits proliferation and invasion of ovarian_cancer cells through Akt and Erk1/2 inactivation by targeting epidermal_growth_factor_receptor .
18243508	0	epidermal_growth_factor_receptor	88,120	Akt-1	135,140	epidermal growth factor receptor	Akt-1	1956	207	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Von_Hippel-Lindau tumor suppressor gene loss in renal_cell_carcinoma promotes oncogenic epidermal_growth_factor_receptor signaling via Akt-1 and MEK-1 .
20726858	0	epidermal_growth_factor_receptor	61,93	Amphiregulin	0,12	epidermal growth factor receptor	Amphiregulin	1956	374	Gene	Gene	signals|compound|START_ENTITY regulates|nmod|signals regulates|nsubj|END_ENTITY	Amphiregulin regulates the activation of ERK and Akt through epidermal_growth_factor_receptor and HER3 signals involved in the progression of pancreatic_cancer .
23333074	0	epidermal_growth_factor_receptor	69,101	Amphiregulin	0,12	epidermal growth factor receptor	Amphiregulin	1956	374	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Amphiregulin enhances regulatory T cell-suppressive function via the epidermal_growth_factor_receptor .
7679104	0	epidermal_growth_factor_receptor	53,85	Amphiregulin	0,12	epidermal growth factor receptor	Amphiregulin	1956	374	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Amphiregulin induces tyrosine phosphorylation of the epidermal_growth_factor_receptor and p185erbB2 .
15329724	0	epidermal_growth_factor_receptor	15,47	Argos	0,5	epidermal growth factor receptor	Argos	37455(Tax:7227)	39833(Tax:7227)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Argos inhibits epidermal_growth_factor_receptor signalling by ligand sequestration .
18682421	0	epidermal_growth_factor_receptor	14,46	BRCA1	62,67	epidermal growth factor receptor	BRCA1	1956	672	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|relation relation|nmod|status status|nummod|END_ENTITY	Expression of epidermal_growth_factor_receptor in relation to BRCA1 status , basal-like markers and prognosis in breast_cancer .
21396117	0	epidermal_growth_factor_receptor	38,70	BRCA1	8,13	epidermal growth factor receptor	BRCA1	13649(Tax:10090)	12189(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increase|nmod|expression leads|nmod|increase leads|nsubj|Loss Loss|nmod|END_ENTITY	Loss of BRCA1 leads to an increase in epidermal_growth_factor_receptor expression in mammary epithelial cells , and epidermal_growth_factor_receptor inhibition prevents estrogen_receptor-negative cancers in BRCA1-mutant mice .
24321281	0	epidermal_growth_factor_receptor	19,51	BRCA1	10,15	epidermal growth factor receptor	BRCA1	1956	672	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of BRCA1 on epidermal_growth_factor_receptor in ovarian_cancer .
24452282	0	epidermal_growth_factor_receptor	20,52	BRCA1	81,86	epidermal growth factor receptor	BRCA1	1956	672	Gene	Gene	gene|compound|START_ENTITY Association|nmod|gene copy|nsubj|Association copy|dobj|number number|appos|expression expression|compound|END_ENTITY	Association between epidermal_growth_factor_receptor gene copy number and ERCC1 , BRCA1 protein expression in Chinese patients with non-small_cell_lung_cancer .
25417703	0	epidermal_growth_factor_receptor	20,52	BRCA1	0,5	epidermal growth factor receptor	BRCA1	1956	672	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nummod|END_ENTITY	BRCA1 regulation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in human breast_cancer cells involves microRNA-146a and is critical for its tumor suppressor function .
25225463	0	epidermal_growth_factor_receptor	14,46	Bcl2	53,57	epidermal growth factor receptor	Bcl2	1956	596	Gene	Gene	epidermal|compound|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
15219825	0	epidermal_growth_factor_receptor	14,46	CCR3	51,55	epidermal growth factor receptor	CCR3	1956	1232	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of epidermal_growth_factor_receptor via CCR3 in bronchial epithelial cells .
23086814	0	epidermal_growth_factor_receptor	46,78	CD73	31,35	epidermal growth factor receptor	CD73	1956	4907	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Potential prognostic biomarker CD73 regulates epidermal_growth_factor_receptor expression in human breast_cancer .
18247373	0	epidermal_growth_factor_receptor	30,62	CD9	16,19	epidermal growth factor receptor	CD9	1956	928	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The tetraspanin CD9 modulates epidermal_growth_factor_receptor signaling in cancer cells .
24246676	0	epidermal_growth_factor_receptor	70,102	CD9	50,53	epidermal growth factor receptor	CD9	1956	928	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|upregulation upregulation|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Pro-MMP-9 upregulation in HT1080 cells expressing CD9 is regulated by epidermal_growth_factor_receptor .
25760022	0	epidermal_growth_factor_receptor	60,92	CD9	0,3	epidermal growth factor receptor	CD9	1956	928	Gene	Gene	cells|nmod|START_ENTITY proliferation|nmod|cells modulates|dobj|proliferation modulates|nsubj|END_ENTITY	CD9 modulates proliferation of human glioblastoma cells via epidermal_growth_factor_receptor signaling .
17877615	0	epidermal_growth_factor_receptor	86,118	COX-2	14,19	epidermal growth factor receptor	COX-2	1956	5743	Gene	Gene	transactivation|compound|START_ENTITY blocking|dobj|transactivation decreases|advcl|blocking decreases|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of COX-2 with NS-398 decreases colon_cancer cell motility through blocking epidermal_growth_factor_receptor transactivation : possibilities for combination therapy .
19671676	0	epidermal_growth_factor_receptor	60,92	COX-2	18,23	epidermal growth factor receptor	COX-2	1956	5743	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|Cyclooxygenase-2 Cyclooxygenase-2|appos|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- negatively regulates expression of epidermal_growth_factor_receptor and causes resistance to gefitinib in COX-2-overexpressing cancer cells .
20850495	0	epidermal_growth_factor_receptor	19,51	COX-2	91,96	epidermal growth factor receptor	COX-2	1956	5743	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|genes genes|compound|END_ENTITY	Involvement of the epidermal_growth_factor_receptor in Pb + - induced activation of cPLA / COX-2 genes and PGE production in vascular smooth muscle cells .
21874253	0	epidermal_growth_factor_receptor	55,87	COX-2	115,120	epidermal growth factor receptor	COX-2	1956	4513	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Lipopolysaccharide initiates a bypass feedback loop of epidermal_growth_factor_receptor signaling by HPS70-induced COX-2 in H22 hepatocarcinoma cells .
21172357	0	epidermal_growth_factor_receptor	60,92	Caveolin-1	0,10	epidermal growth factor receptor	Caveolin-1	1956	857	Gene	Gene	transactivation|compound|START_ENTITY regulates|dobj|transactivation regulates|nsubj|END_ENTITY	Caveolin-1 negatively regulates a metalloprotease-dependent epidermal_growth_factor_receptor transactivation by angiotensin_II .
11799118	0	epidermal_growth_factor_receptor	74,106	Cdc42	4,9	epidermal growth factor receptor	Cdc42	1956	998	Gene	Gene	degradation|compound|START_ENTITY regulate|dobj|degradation sorting_nexin_9|acl|regulate interacts|nmod|sorting_nexin_9 interacts|nsubj|ACK2 ACK2|amod|END_ENTITY	The Cdc42 target ACK2 interacts with sorting_nexin_9 -LRB- SH3PX1 -RRB- to regulate epidermal_growth_factor_receptor degradation .
16472692	0	epidermal_growth_factor_receptor	15,47	Cdc42	72,77	epidermal growth factor receptor	Cdc42	1956	998	Gene	Gene	turnover|compound|START_ENTITY Measurement|nmod|turnover Measurement|nmod|END_ENTITY	Measurement of epidermal_growth_factor_receptor turnover and effects of Cdc42 .
16585176	0	epidermal_growth_factor_receptor	57,89	Cdc42	137,142	epidermal growth factor receptor	Cdc42	1956	998	Gene	Gene	degradation|compound|START_ENTITY cells|nmod|degradation inhibition|nmod|cells correlated|nsubjpass|inhibition correlated|nmod|inactivation inactivation|nmod|END_ENTITY	Growth and motility inhibition of breast_cancer cells by epidermal_growth_factor_receptor degradation is correlated with inactivation of Cdc42 .
18057010	0	epidermal_growth_factor_receptor	69,101	Cdc42	0,5	epidermal growth factor receptor	Cdc42	1956	998	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal_growth_factor_receptor to Src-mediated pathway .
23929714	0	epidermal_growth_factor_receptor	51,83	Connective_tissue_growth_factor	0,31	epidermal growth factor receptor	Connective tissue growth factor	13649(Tax:10090)	14219(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Connective_tissue_growth_factor is a new ligand of epidermal_growth_factor_receptor .
15777970	0	epidermal_growth_factor_receptor	51,83	Cyclooxygenase-2	0,16	epidermal growth factor receptor	Cyclooxygenase-2	1956	5743	Gene	Gene	expression|compound|START_ENTITY independent|nmod|expression independent|nsubj|levels levels|amod|END_ENTITY	Cyclooxygenase-2 protein levels are independent of epidermal_growth_factor_receptor expression or activation in operable non-small_cell_lung_cancer .
15844661	0	epidermal_growth_factor_receptor	108,140	Cyclooxygenase-2	0,16	epidermal growth factor receptor	Cyclooxygenase-2	1956	5743	Gene	Gene	consequence|nmod|START_ENTITY squamous_cell_carcinoma|nmod|consequence induction|nmod|squamous_cell_carcinoma induction|amod|END_ENTITY	Cyclooxygenase-2 induction and prostaglandin_E2 accumulation in squamous_cell_carcinoma as a consequence of epidermal_growth_factor_receptor activation by imatinib_mesylate .
17572069	0	epidermal_growth_factor_receptor	36,68	Cyclooxygenase-2	0,16	epidermal growth factor receptor	Cyclooxygenase-2	1956	5743	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	Cyclooxygenase-2 transactivates the epidermal_growth_factor_receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme .
18645679	0	epidermal_growth_factor_receptor	46,78	Cyclooxygenase-2	0,16	epidermal growth factor receptor	Cyclooxygenase-2	1956	5743	Gene	Gene	expression|compound|START_ENTITY dependent|nmod|expression dependent|nsubj|expression expression|amod|END_ENTITY	Cyclooxygenase-2 expression is dependent upon epidermal_growth_factor_receptor expression or activation in androgen_independent_prostate_cancer .
19585617	0	epidermal_growth_factor_receptor	76,108	Cyclooxygenase-2	0,16	epidermal growth factor receptor	Cyclooxygenase-2	13649(Tax:10090)	19225(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY prevents|nmod|up-regulation prevents|nsubj|END_ENTITY	Cyclooxygenase-2 prevents fas-induced liver_injury through up-regulation of epidermal_growth_factor_receptor .
19671676	0	epidermal_growth_factor_receptor	60,92	Cyclooxygenase-2	0,16	epidermal growth factor receptor	Cyclooxygenase-2	1956	5743	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cyclooxygenase-2 -LRB- COX-2 -RRB- negatively regulates expression of epidermal_growth_factor_receptor and causes resistance to gefitinib in COX-2-overexpressing cancer cells .
9452417	0	epidermal_growth_factor_receptor	22,54	Decorin	0,7	epidermal growth factor receptor	Decorin	1956	1634	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Decorin activates the epidermal_growth_factor_receptor and elevates cytosolic Ca2 + in A431 carcinoma cells .
9988678	0	epidermal_growth_factor_receptor	39,71	Decorin	0,7	epidermal growth factor receptor	Decorin	1956	1634	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Decorin is a biological ligand for the epidermal_growth_factor_receptor .
12027444	0	epidermal_growth_factor_receptor	87,119	E-cadherin	45,55	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	inhibitors|compound|START_ENTITY treatment|nmod|inhibitors sensitive|nmod|treatment sensitive|nsubj|enhancement enhancement|nmod|END_ENTITY	Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal_growth_factor_receptor and phosphatidylinositol 3-kinase inhibitors .
16424029	0	epidermal_growth_factor_receptor	57,89	E-cadherin	10,20	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	sensitivity|xcomp|START_ENTITY sensitivity|nsubj|increases increases|amod|END_ENTITY	Restoring E-cadherin expression increases sensitivity to epidermal_growth_factor_receptor inhibitors in lung_cancer cell lines .
18057010	0	epidermal_growth_factor_receptor	69,101	E-cadherin	16,26	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|ubiquitination ubiquitination|amod|END_ENTITY	Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal_growth_factor_receptor to Src-mediated pathway .
18245470	0	epidermal_growth_factor_receptor	23,55	E-cadherin	80,90	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	activation|nmod|START_ENTITY caused|nsubj|activation caused|nmod|mutations mutations|amod|END_ENTITY	Enhanced activation of epidermal_growth_factor_receptor caused by tumor-derived E-cadherin mutations .
18316572	0	epidermal_growth_factor_receptor	15,47	E-cadherin	67,77	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	requires|dep|START_ENTITY requires|nsubj|expression expression|amod|END_ENTITY	Sensitivity to epidermal_growth_factor_receptor inhibitor requires E-cadherin expression in urothelial_carcinoma cells .
21211535	0	epidermal_growth_factor_receptor	56,88	E-cadherin	8,18	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	activating|dobj|START_ENTITY promotes|advcl|activating promotes|nsubj|END_ENTITY	Soluble E-cadherin promotes cell survival by activating epidermal_growth_factor_receptor .
23749888	0	epidermal_growth_factor_receptor	15,47	E-cadherin	83,93	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	requires|dep|START_ENTITY requires|nsubj|END_ENTITY	Sensitivity to epidermal_growth_factor_receptor tyrosine kinase inhibitor requires E-cadherin in esophageal_cancer and malignant_pleural_mesothelioma .
7826368	0	epidermal_growth_factor_receptor	34,66	E-cadherin	9,19	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Enhanced E-cadherin expression in epidermal_growth_factor_receptor expressing cells .
8635495	0	epidermal_growth_factor_receptor	35,67	E-cadherin	113,123	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	results|compound|START_ENTITY results|nmod|function function|amod|END_ENTITY	Ligand activation of overexpressed epidermal_growth_factor_receptor results in colony_dissociation and disturbed E-cadherin function in HSC-1 human cutaneous squamous_carcinoma cells .
8912870	0	epidermal_growth_factor_receptor	43,75	E-cadherin	0,10	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|transfection transfection|amod|END_ENTITY	E-cadherin transfection down-regulates the epidermal_growth_factor_receptor and reverses the invasive phenotype of human_papilloma_virus-transfected keratinocytes .
9535896	0	epidermal_growth_factor_receptor	4,36	E-cadherin	66,76	epidermal growth factor receptor	E-cadherin	1956	999	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|interaction interaction|nmod|END_ENTITY	The epidermal_growth_factor_receptor modulates the interaction of E-cadherin with the actin cytoskeleton .
9293917	0	epidermal_growth_factor_receptor	14,46	E6/E7	72,77	epidermal growth factor receptor	E6/E7	1956	25479186	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor and human_papillomavirus E6/E7 proteins in cervical_carcinoma cells .
11999807	0	epidermal_growth_factor_receptor	36,68	EGF-R	70,75	epidermal growth factor receptor	EGF-R	1956	1956	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- in normal and diseased newborn lung tissues .
2544220	0	epidermal_growth_factor_receptor	14,46	EGF-R	48,53	epidermal growth factor receptor	EGF-R	1956	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- in non-small_cell_lung_cancer .
3017396	0	epidermal_growth_factor_receptor	14,46	EGF-R	48,53	epidermal growth factor receptor	EGF-R	1956	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- in human lung_tumours .
7507841	0	epidermal_growth_factor_receptor	27,59	EGF-R	61,66	epidermal growth factor receptor	EGF-R	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Differential expression of epidermal_growth_factor_receptor -LRB- EGF-R -RRB- gene and regulation of EGF-R bioactivity by progesterone and estrogen in the adult mouse uterus .
8291440	0	epidermal_growth_factor_receptor	13,45	EGF-R	47,52	epidermal growth factor receptor	EGF-R	1956	1956	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Heterologous epidermal_growth_factor_receptor -LRB- EGF-R -RRB- expression in larynx_cancer cell lines : evidence for the existence of structurally modified receptors .
10411339	0	epidermal_growth_factor_receptor	39,71	EGFR	73,77	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Acquired rearrangement of an amplified epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in a human glioblastoma xenograft .
10463620	0	epidermal_growth_factor_receptor	42,74	EGFR	76,80	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Intragenic mutation analysis of the human epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in malignant human oral keratinocytes .
12008195	0	epidermal_growth_factor_receptor	54,86	EGFR	88,92	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Phase I and pharmacokinetic study of BIBX 1382 BS , an epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitor , given in a continuous daily oral administration .
15221011	0	epidermal_growth_factor_receptor	25,57	EGFR	128,132	epidermal growth factor receptor	EGFR	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|survival survival|nmod|END_ENTITY	The tumor-specific de2-7 epidermal_growth_factor_receptor -LRB- EGFR -RRB- promotes cells survival and heterodimerizes with the wild-type EGFR .
15644326	0	epidermal_growth_factor_receptor	27,59	EGFR	61,65	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Simultaneous inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- signaling and enhanced activation of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptor-mediated apoptosis induction by an scFv : sTRAIL fusion protein with specificity for human EGFR .
15718144	0	epidermal_growth_factor_receptor	12,44	EGFR	46,50	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Blockade of epidermal_growth_factor_receptor -LRB- EGFR -RRB- activity .
15829495	0	epidermal_growth_factor_receptor	56,88	EGFR	90,94	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of the dinucleotide repeat polymorphism in the epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in head_and_neck_cancer patients .
15967033	0	epidermal_growth_factor_receptor	21,53	EGFR	55,59	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	Prognostic impact of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression on loco-regional recurrence after preoperative radiotherapy in rectal_cancer .
16203806	0	epidermal_growth_factor_receptor	87,119	EGFR	142,146	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	START_ENTITY|dep|signaling signaling|nmod|END_ENTITY	Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A '' - DTPA-hu3S193 by inhibition of epidermal_growth_factor_receptor -LRB- EGFR -RRB- signaling with EGFR tyrosine kinase inhibitor AG1478 .
16279103	0	epidermal_growth_factor_receptor	15,47	EGFR	49,53	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in ovarian_carcinoma stage III-IV -RSB- .
16311351	0	epidermal_growth_factor_receptor	27,59	EGFR	61,65	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Frequent overexpression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in mammary high grade ductal_carcinomas with myoepithelial differentiation .
16428503	0	epidermal_growth_factor_receptor	43,75	EGFR	77,81	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Novel toll-like_receptor_9 agonist induces epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibition and synergistic antitumor activity with EGFR inhibitors .
16637298	0	epidermal_growth_factor_receptor	33,65	EGFR	27,31	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	-LSB- Trophoblast expression of EGFR -LRB- epidermal_growth_factor_receptor -RRB- in the preeclampsia placenta -RSB- .
16919868	0	epidermal_growth_factor_receptor	25,57	EGFR	59,63	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutational status of the epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in thymomas_and_thymic_carcinomas .
17011067	0	epidermal_growth_factor_receptor	58,90	EGFR	92,96	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Clinicopathologic features and prognostic implications of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene copy number and protein expression in non-small_cell_lung_cancer .
17052260	0	epidermal_growth_factor_receptor	79,111	EGFR	113,117	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Clinical usefulness of serum telomerase reverse transcriptase -LRB- hTERT -RRB- mRNA and epidermal_growth_factor_receptor -LRB- EGFR -RRB- mRNA as a novel tumor marker for lung_cancer .
17192868	0	epidermal_growth_factor_receptor	13,45	EGFR	47,51	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene mutations on the expression of EGFR , phosphoryl-Akt , and phosphoryl-MAPK , and on the prognosis of patients with non-small_cell_lung_cancer .
17354229	0	epidermal_growth_factor_receptor	10,42	EGFR	44,48	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of epidermal_growth_factor_receptor -LRB- EGFR -RRB- kinase mutations , EGFR gene amplifications , and KRAS mutations on survival of pancreatic_adenocarcinoma .
17468034	0	epidermal_growth_factor_receptor	15,47	EGFR	49,53	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene copy number amplification with neck lymph node metastasis in areca-associated oral_carcinomas .
17609586	0	epidermal_growth_factor_receptor	83,115	EGFR	117,121	epidermal growth factor receptor	EGFR	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Combination treatment with ionising radiation and gefitinib -LRB- ` Iressa ' , ZD1839 -RRB- , an epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitor , significantly inhibits bladder_cancer cell growth in vitro and in vivo .
18519677	0	epidermal_growth_factor_receptor	51,83	EGFR	85,89	epidermal growth factor receptor	EGFR	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	RET/PTC-induced cell growth is mediated in part by epidermal_growth_factor_receptor -LRB- EGFR -RRB- activation : evidence for molecular and functional interactions between RET and EGFR .
19416119	0	epidermal_growth_factor_receptor	8,40	EGFR	42,46	epidermal growth factor receptor	EGFR	24329(Tax:10116)	24329(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in corneal_remodelling in diabetes .
19434314	0	epidermal_growth_factor_receptor	51,83	EGFR	85,89	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression and significance of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in breast_cancer .
19620791	0	epidermal_growth_factor_receptor	46,78	EGFR	80,84	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Small-molecule tyrosine kinase inhibitors of epidermal_growth_factor_receptor -LRB- EGFR -RRB- -RSB- .
20399639	0	epidermal_growth_factor_receptor	28,60	EGFR	62,66	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cytotoxic drugs up-regulate epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in colon_cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent_cell-mediated-cytotoxicity -LRB- ADCC -RRB- .
20446909	0	epidermal_growth_factor_receptor	32,64	EGFR	26,30	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Cardiovascular effects of EGFR -LRB- epidermal_growth_factor_receptor -RRB- monoclonal antibodies .
20532621	0	epidermal_growth_factor_receptor	30,62	EGFR	64,68	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Hypoxia-induced activation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- kinase in the cerebral cortex of newborn piglets : the role of nitric_oxide .
20579333	0	epidermal_growth_factor_receptor	34,66	EGFR	68,72	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in oral_squamous_cell_carcinoma in relation to proliferation , apoptosis , angiogenesis and lymphangiogenesis .
20956544	0	epidermal_growth_factor_receptor	17,49	EGFR	51,55	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	ErbB2 stabilizes epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression via Erk and Sprouty2 in extracellular matrix-detached cells .
21199607	0	epidermal_growth_factor_receptor	35,67	EGFR	91,95	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|nmod|START_ENTITY Correlations|nmod|expression phosphorylated|nsubj|Correlations phosphorylated|dobj|variables variables|amod|END_ENTITY	Correlations between expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , phosphorylated EGFR , cyclooxygenase-2 and clinicopathological variables and treatment outcomes in nasopharyngeal_carcinomas .
21457545	0	epidermal_growth_factor_receptor	17,49	EGFR	51,55	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in triple negative breast_cancer : possible implications for targeted therapy .
21482992	0	epidermal_growth_factor_receptor	68,100	EGFR	102,106	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	Mutation|compound|START_ENTITY Mutation|appos|END_ENTITY	American Society of Clinical Oncology provisional_clinical_opinion : epidermal_growth_factor_receptor -LRB- EGFR -RRB- Mutation testing for patients with advanced non-small-cell_lung_cancer considering first-line EGFR tyrosine kinase inhibitor therapy .
21512415	0	epidermal_growth_factor_receptor	31,63	EGFR	65,69	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Tyrosine kinase inhibitors and epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutations in non-small cell lung cancer : to test or not to test ?
21626329	0	epidermal_growth_factor_receptor	31,63	EGFR	65,69	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	The influence of intracellular epidermal_growth_factor_receptor -LRB- EGFR -RRB- signal activation on the outcome of EGFR tyrosine kinase inhibitor treatment for pulmonary_adenocarcinoma .
21789142	0	epidermal_growth_factor_receptor	21,53	EGFR	55,59	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The emerging role of epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitors in first-line treatment for patients with advanced non-small_cell_lung_cancer positive for EGFR mutations .
22003817	0	epidermal_growth_factor_receptor	78,110	EGFR	112,116	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Design and synthesis of novel human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- / epidermal_growth_factor_receptor -LRB- EGFR -RRB- dual inhibitors bearing a pyrrolo -LSB- 3,2-d -RSB- pyrimidine scaffold .
22026926	0	epidermal_growth_factor_receptor	10,42	EGFR	44,48	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene in European patients with advanced colorectal_cancer harbors infrequent mutations in its tyrosine kinase domain .
22085274	0	epidermal_growth_factor_receptor	15,47	EGFR	49,53	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Suppression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression by small hairpin RNA inhibits the growth of human nonsmall_cell_lung_cancers bearing wild-type and mutant EGFR .
22361824	0	epidermal_growth_factor_receptor	43,75	EGFR	77,81	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Semiology of skin_toxicity associated with epidermal_growth_factor_receptor -LRB- EGFR -RRB- inhibitors .
23064060	0	epidermal_growth_factor_receptor	119,151	EGFR	152,156	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	The pharmacokinetics and long-term therapeutic effects of gefitinib in patients with lung_adenocarcinoma harboring the epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation .
23327060	0	epidermal_growth_factor_receptor	12,44	EGFR	46,50	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Analysis of epidermal_growth_factor_receptor -LRB- EGFR -RRB- status in endometrial_stromal_sarcoma .
23910906	0	epidermal_growth_factor_receptor	102,134	EGFR	136,140	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A prospective , phase II , open-label study -LRB- JO22903 -RRB- of first-line erlotinib in Japanese patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation-positive advanced non-small-cell_lung_cancer -LRB- NSCLC -RRB- .
24344129	0	epidermal_growth_factor_receptor	71,103	EGFR	105,109	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	UBE4B protein couples ubiquitination and sorting machineries to enable epidermal_growth_factor_receptor -LRB- EGFR -RRB- degradation .
25259789	0	epidermal_growth_factor_receptor	31,63	EGFR	65,69	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Clinical significance of serum epidermal_growth_factor_receptor -LRB- EGFR -RRB- levels in patients with breast_cancer .
25417703	0	epidermal_growth_factor_receptor	20,52	EGFR	54,58	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	BRCA1 regulation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression in human breast_cancer cells involves microRNA-146a and is critical for its tumor suppressor function .
2570489	0	epidermal_growth_factor_receptor	17,49	EGFR	51,55	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Amplification of epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene and oncogenes in human gastric_carcinomas .
25991665	0	epidermal_growth_factor_receptor	24,56	EGFR	58,62	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Nuclear localization of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in ameloblastomas .
26199571	0	epidermal_growth_factor_receptor	37,69	EGFR	71,75	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The prognostic significance of tumor epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression change after neoadjuvant chemoradiation in patients with rectal_adenocarcinoma .
26199571	0	epidermal_growth_factor_receptor	37,69	EGFR	71,75	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The prognostic significance of tumor epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression change after neoadjuvant chemoradiation in patients with rectal_adenocarcinoma .
26464643	0	epidermal_growth_factor_receptor	21,53	EGFR	55,59	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	Relationship between epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation and serum cyclooxygenase-2 Level , and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small_cell_lung_cancer cells .
26944829	0	epidermal_growth_factor_receptor	39,71	EGFR	73,77	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Inner nuclear membrane localization of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in spontaneous canine model of invasive micropapillary_carcinoma of the mammary gland .
7475300	0	epidermal_growth_factor_receptor	14,46	EGFR	48,52	epidermal growth factor receptor	EGFR	24329(Tax:10116)	24329(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression on in vivo growth of rat C6 glioma cells .
7949212	0	epidermal_growth_factor_receptor	14,46	EGFR	48,52	epidermal growth factor receptor	EGFR	404306(Tax:9615)	404306(Tax:9615)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in non-affected and tumorous mammary tissue of female dogs .
7970118	0	epidermal_growth_factor_receptor	29,61	EGFR	63,67	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in various types of renal_injury .
8142117	0	epidermal_growth_factor_receptor	24,56	EGFR	58,62	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The prognostic value of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in breast_cancer patients .
8513016	0	epidermal_growth_factor_receptor	52,84	EGFR	86,90	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Proto-oncogene of genomic DNA , related to the human epidermal_growth_factor_receptor -LRB- EGFR -RRB- gene , from clinically normal domestic animals .
8758275	0	epidermal_growth_factor_receptor	15,47	EGFR	49,53	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- in endometrioid_carcinoma_of_the_ovary -RSB- .
9475680	0	epidermal_growth_factor_receptor	45,77	EGFR	79,83	epidermal growth factor receptor	EGFR	1956	1956	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Altered mRNA expression pattern of placental epidermal_growth_factor_receptor -LRB- EGFR -RRB- in pregnancies complicated by preeclampsia and/or intrauterine_growth_retardation .
10998445	0	epidermal_growth_factor_receptor	11,43	EGFr	45,49	epidermal growth factor receptor	EGFr	1956	1956	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Profile of epidermal_growth_factor_receptor -LRB- EGFr -RRB- expression in human malignancies : effects of exposure to EGF and its biological influence on established human tumour cell lines .
7810909	0	epidermal_growth_factor_receptor	14,46	EGFr	48,52	epidermal growth factor receptor	EGFr	1956	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of epidermal_growth_factor_receptor -LRB- EGFr -RRB- immunoreactivity in human cutaneous nerves and sensory corpuscles .
15855163	0	epidermal_growth_factor_receptor	149,181	EP1	109,112	epidermal growth factor receptor	EP1	1956	5731	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin_E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
26188043	0	epidermal_growth_factor_receptor	149,181	EP1	109,112	epidermal growth factor receptor	EP1	1956	5731	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
26188043	0	epidermal_growth_factor_receptor	149,181	EP1	109,112	epidermal growth factor receptor	EP1	1956	5731	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal_growth_factor_receptor and Akt .
21205091	0	epidermal_growth_factor_receptor	14,46	EP4	92,95	epidermal growth factor receptor	EP4	13649(Tax:10090)	19219(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation of epidermal_growth_factor_receptor signaling by the prostaglandin_E -LRB- 2 -RRB- receptor EP4 pathway during gastric tumorigenesis .
11319218	0	epidermal_growth_factor_receptor	83,115	ERK	18,21	epidermal growth factor receptor	ERK	1956	5594	Gene	Gene	signaling|compound|START_ENTITY downstream|nmod|signaling required|nmod|downstream required|nsubjpass|signaling signaling|compound|END_ENTITY	Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal_growth_factor_receptor signaling .
15572377	0	epidermal_growth_factor_receptor	76,108	ERK	8,11	epidermal growth factor receptor	ERK	1956	2048	Gene	Gene	contributions|nmod|START_ENTITY reveals|dobj|contributions reveals|nsubj|activation activation|compound|END_ENTITY	Parsing ERK activation reveals quantitatively equivalent contributions from epidermal_growth_factor_receptor and HER2 in human mammary epithelial cells .
18174162	0	epidermal_growth_factor_receptor	29,61	ERK	62,65	epidermal growth factor receptor	ERK	13649(Tax:10090)	13844(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	p66shc inhibits pro-survival epidermal_growth_factor_receptor / ERK signaling during severe oxidative stress in mouse renal proximal tubule cells .
19499796	0	epidermal_growth_factor_receptor	68,100	ERK	36,39	epidermal growth factor receptor	ERK	1956	5594	Gene	Gene	-RSB-|compound|START_ENTITY activated|nmod|-RSB- signal|dep|activated signal|nsubj|simulation simulation|nmod|END_ENTITY	-LSB- Dynamic simulation and analysis of ERK signal pathway activated by epidermal_growth_factor_receptor -RSB- .
19559020	0	epidermal_growth_factor_receptor	15,47	ERK	116,119	epidermal growth factor receptor	ERK	1956	5594	Gene	Gene	reduction|nmod|START_ENTITY involved|nsubjpass|reduction involved|nmod|inhibition inhibition|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	A reduction of epidermal_growth_factor_receptor is involved in brefelamide-induced inhibition of phosphorylation of ERK in human astrocytoma cells .
20407013	0	epidermal_growth_factor_receptor	91,123	ERK	137,140	epidermal growth factor receptor	ERK	13649(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Activation by tyrosine phosphorylation as a prerequisite for protein kinase C to mediate epidermal_growth_factor_receptor signaling to ERK .
20650261	0	epidermal_growth_factor_receptor	14,46	ERK	99,102	epidermal growth factor receptor	ERK	13649(Tax:10090)	26413(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY variant|nsubj|effect variant|advcl|stimulating stimulating|dobj|phosphorylation phosphorylation|compound|END_ENTITY	The effect of epidermal_growth_factor_receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway .
20726858	0	epidermal_growth_factor_receptor	61,93	ERK	41,44	epidermal growth factor receptor	ERK	1956	5594	Gene	Gene	signals|compound|START_ENTITY regulates|nmod|signals regulates|dobj|activation activation|nmod|END_ENTITY	Amphiregulin regulates the activation of ERK and Akt through epidermal_growth_factor_receptor and HER3 signals involved in the progression of pancreatic_cancer .
22542783	0	epidermal_growth_factor_receptor	61,93	ERK	33,36	epidermal growth factor receptor	ERK	1956	5594	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|dobj|activation activation|nmod|END_ENTITY	Globoside promotes activation of ERK by interaction with the epidermal_growth_factor_receptor .
24071787	0	epidermal_growth_factor_receptor	76,108	ERK1/2	53,59	epidermal growth factor receptor	ERK1/2	24329(Tax:10116)	50689;116590	Gene	Gene	facilitates|nmod|START_ENTITY facilitates|dobj|activation activation|nmod|END_ENTITY	Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal_growth_factor_receptor in rat granulosa cells .
24566221	0	epidermal_growth_factor_receptor	50,82	ERK1/2	164,170	epidermal growth factor receptor	ERK1/2	24329(Tax:10116)	50689;116590	Gene	Gene	transactivation|nmod|START_ENTITY decreases|nsubj|transactivation decreases|nmod|activation activation|nmod|END_ENTITY	b-Adrenergic receptor-mediated transactivation of epidermal_growth_factor_receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt .
9692677	0	epidermal_growth_factor_receptor	34,66	ERK2	0,4	epidermal growth factor receptor	ERK2	1956	5594	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	ERK2 signalling from internalised epidermal_growth_factor_receptor in broken A431 cells .
18685792	0	epidermal_growth_factor_receptor	63,95	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	interaction|nmod|START_ENTITY changes|nmod|interaction induces|dobj|changes induces|nsubj|END_ENTITY	Epidermal_growth_factor induces changes of interaction between epidermal_growth_factor_receptor and actin in intact cells .
19766894	0	epidermal_growth_factor_receptor	33,65	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	accumulation|amod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	Epidermal_growth_factor promotes epidermal_growth_factor_receptor nuclear accumulation by a pathway dependent on cytoskeleton integrity in human breast_cancer cells .
20073577	0	epidermal_growth_factor_receptor	75,107	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	absence|nmod|START_ENTITY death|nmod|absence induces|dobj|death induces|nsubj|END_ENTITY	Epidermal_growth_factor induces cell death in the absence of overexpressed epidermal_growth_factor_receptor and ErbB2 in various human cancer cell lines .
2162268	0	epidermal_growth_factor_receptor	118,150	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	24329(Tax:10116)	25313(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY accelerates|parataxis|role accelerates|nsubj|END_ENTITY	Epidermal_growth_factor accelerates functional recovery from ischaemic acute_tubular_necrosis in the rat : role of the epidermal_growth_factor_receptor .
3494473	0	epidermal_growth_factor_receptor	78,110	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	aggregation|nmod|START_ENTITY induces|dobj|aggregation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces rapid , reversible aggregation of the purified epidermal_growth_factor_receptor .
6321474	0	epidermal_growth_factor_receptor	66,98	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	phosphorylation|compound|START_ENTITY induce|dobj|phosphorylation induce|nsubj|promoters promoters|compound|END_ENTITY	Epidermal_growth_factor and potent phorbol tumor promoters induce epidermal_growth_factor_receptor phosphorylation in a similar but distinctively different manner in human epidermoid_carcinoma A431 cells .
7508718	0	epidermal_growth_factor_receptor	110,142	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	translocation|nmod|START_ENTITY associated|nmod|translocation proteins|acl|associated phosphorylation|nmod|proteins tyrosine|dobj|phosphorylation tyrosine|nsubj|induced induced|compound|END_ENTITY	Epidermal_growth_factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal_growth_factor_receptor into the nucleus .
7558411	0	epidermal_growth_factor_receptor	83,115	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	down-regulates|amod|START_ENTITY expression|dep|down-regulates expression|amod|END_ENTITY	Epidermal_growth_factor expression in human colon_and_colon_carcinomas : anti-sense epidermal_growth_factor_receptor RNA down-regulates the proliferation of human colon_cancer cells .
8262933	0	epidermal_growth_factor_receptor	89,121	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	separable|nmod|START_ENTITY kinase|acl:relcl|separable stimulates|dobj|kinase stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates a protein tyrosine kinase which is separable from the epidermal_growth_factor_receptor .
8785711	0	epidermal_growth_factor_receptor	77,109	Epidermal_growth_factor	0,23	epidermal growth factor receptor	Epidermal growth factor	1956	1950	Gene	Gene	cells|nmod|START_ENTITY mediated|nmod|cells mediated|nsubj|END_ENTITY	Epidermal_growth_factor mediated DNA delivery into lung_cancer cells via the epidermal_growth_factor_receptor .
8251654	0	epidermal_growth_factor_receptor	53,85	Epidermal_growth_factor_receptor	0,32	epidermal growth factor receptor	Epidermal growth factor receptor	1956	1956	Gene	Gene	increase|nmod|START_ENTITY increase|amod|END_ENTITY	Epidermal_growth_factor_receptor levels increase but epidermal_growth_factor_receptor ligand levels decrease in mouse mammary_tumors during progression from hormone dependence to hormone independence .
9419975	0	epidermal_growth_factor_receptor	20,52	Epiregulin	0,10	epidermal growth factor receptor	Epiregulin	1956	2069	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Epiregulin binds to epidermal_growth_factor_receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal_growth_factor_receptor , ErbB-2 , ErbB-3 and ErbB-4 .
9424019	0	epidermal_growth_factor_receptor	114,146	Epiregulin	0,10	epidermal growth factor receptor	Epiregulin	100008806(Tax:9986)	100343410(Tax:9986)	Gene	Gene	autophosphorylation|nmod|START_ENTITY stimulates|nmod|autophosphorylation stimulates|nsubj|END_ENTITY	Epiregulin stimulates proliferation of rabbit gastric cells in primary culture through autophosphorylation of the epidermal_growth_factor_receptor .
8404850	0	epidermal_growth_factor_receptor	26,58	Eps8	0,4	epidermal growth factor receptor	Eps8	1956	2059	Gene	Gene	kinase|compound|START_ENTITY substrate|nmod|kinase END_ENTITY|appos|substrate	Eps8 , a substrate for the epidermal_growth_factor_receptor kinase , enhances EGF-dependent mitogenic signals .
8617810	0	epidermal_growth_factor_receptor	34,66	ErbB	4,8	epidermal growth factor receptor	ErbB	1956	1956	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	All ErbB receptors other than the epidermal_growth_factor_receptor are endocytosis impaired .
12467226	0	epidermal_growth_factor_receptor	37,69	ErbB-2	70,76	epidermal growth factor receptor	ErbB-2	1956	2064	Gene	Gene	effects|nmod|START_ENTITY effects|parataxis|tyrosine tyrosine|nsubj|END_ENTITY	The effects of the novel , reversible epidermal_growth_factor_receptor / ErbB-2 tyrosine kinase inhibitor , GW2016 , on the growth of human normal and tumor-derived cell lines in vitro and in vivo .
15718311	0	epidermal_growth_factor_receptor	16,48	ErbB-2	63,69	epidermal growth factor receptor	ErbB-2	1956	2064	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Relationship of epidermal_growth_factor_receptor expression to ErbB-2 signaling activity and prognosis in breast_cancer patients .
12411582	0	epidermal_growth_factor_receptor	81,113	ErbB3	129,134	epidermal growth factor receptor	ErbB3	1956	2065	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal_growth_factor_receptor family member , ErbB3 .
17475774	0	epidermal_growth_factor_receptor	47,79	Erk	80,83	epidermal growth factor receptor	Erk	1956	2048	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|signaling signaling|nsubj|END_ENTITY	Inhibition of integrin-mediated crosstalk with epidermal_growth_factor_receptor / Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death .
20956544	0	epidermal_growth_factor_receptor	17,49	Erk	72,75	epidermal growth factor receptor	Erk	1956	5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	ErbB2 stabilizes epidermal_growth_factor_receptor -LRB- EGFR -RRB- expression via Erk and Sprouty2 in extracellular matrix-detached cells .
17074804	0	epidermal_growth_factor_receptor	50,82	Erk1/2	143,149	epidermal growth factor receptor	Erk1/2	1956	5595	Gene	Gene	transactivation|compound|START_ENTITY transactivation|nmod|kinase kinase|amod|END_ENTITY	Progesterone_receptors upregulate Wnt-1 to induce epidermal_growth_factor_receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast_cancer cells .
9545268	0	epidermal_growth_factor_receptor	72,104	FK506-binding_protein_12	11,35	epidermal growth factor receptor	FK506-binding protein 12	1956	2280	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of FK506-binding_protein_12 and FK506 on autophosphorylation of epidermal_growth_factor_receptor .
18084281	0	epidermal_growth_factor_receptor	13,45	GEP100	0,6	epidermal growth factor receptor	GEP100	1956	9922	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	GEP100 links epidermal_growth_factor_receptor signalling to Arf6 activation to induce breast_cancer_invasion .
22912784	0	epidermal_growth_factor_receptor	102,134	GM-CSF	55,61	epidermal growth factor receptor	GM-CSF	1956	1437	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Proteasome inhibition augments cigarette smoke-induced GM-CSF expression in trophoblast cells via the epidermal_growth_factor_receptor .
10551845	0	epidermal_growth_factor_receptor	3,35	Gab1	36,40	epidermal growth factor receptor	Gab1	1956	2549	Gene	Gene	START_ENTITY|parataxis|required required|nsubjpass|signaling signaling|compound|END_ENTITY	An epidermal_growth_factor_receptor / Gab1 signaling pathway is required for activation of phosphoinositide 3-kinase by lysophosphatidic_acid .
15967120	0	epidermal_growth_factor_receptor	62,94	Gastrin-releasing_peptide_receptor	0,34	epidermal growth factor receptor	Gastrin-releasing peptide receptor	1956	2925	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Gastrin-releasing_peptide_receptor mediates activation of the epidermal_growth_factor_receptor in lung_cancer cells .
9506989	0	epidermal_growth_factor_receptor	101,133	Grb10	142,147	epidermal growth factor receptor	Grb10	1956	2887	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Grb10 interacts differentially with the insulin_receptor , insulin-like growth factor I receptor , and epidermal_growth_factor_receptor via the Grb10 Src homology 2 -LRB- SH2 -RRB- domain and a second novel domain located between the pleckstrin homology and SH2 domains .
2789066	0	epidermal_growth_factor_receptor	44,76	Growth_hormone	0,14	epidermal growth factor receptor	Growth hormone	24329(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Growth_hormone regulates the rodent hepatic epidermal_growth_factor_receptor at a pretranslational level .
3264288	0	epidermal_growth_factor_receptor	32,64	Growth_hormone	0,14	epidermal growth factor receptor	Growth hormone	13649(Tax:10090)	14599(Tax:10090)	Gene	Gene	concentration|compound|START_ENTITY enhances|dobj|concentration enhances|nsubj|END_ENTITY	Growth_hormone enhances hepatic epidermal_growth_factor_receptor concentration in mice .
20029029	0	epidermal_growth_factor_receptor	14,46	HDAC6	81,86	epidermal growth factor receptor	HDAC6	1956	10013	Gene	Gene	trafficking|compound|START_ENTITY Regulation|nmod|trafficking Regulation|nmod|END_ENTITY	Regulation of epidermal_growth_factor_receptor trafficking by lysine deacetylase HDAC6 .
20133936	0	epidermal_growth_factor_receptor	67,99	HDAC6	50,55	epidermal growth factor receptor	HDAC6	1956	10013	Gene	Gene	trafficking|nsubj|START_ENTITY regulates|xcomp|trafficking regulates|nsubj|histone_deacetylase_6 histone_deacetylase_6|appos|END_ENTITY	The microtubule-associated histone_deacetylase_6 -LRB- HDAC6 -RRB- regulates epidermal_growth_factor_receptor -LRB- EGFR -RRB- endocytic trafficking and degradation .
23152903	0	epidermal_growth_factor_receptor	16,48	HDAC6	0,5	epidermal growth factor receptor	HDAC6	13649(Tax:10090)	15185(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	HDAC6 regulates epidermal_growth_factor_receptor -LRB- EGFR -RRB- endocytic trafficking and degradation in renal epithelial cells .
1354348	0	epidermal_growth_factor_receptor	67,99	HER-2	37,42	epidermal growth factor receptor	HER-2	1956	2064	Gene	Gene	independent|nmod|START_ENTITY independent|compound|END_ENTITY	Transformation mediated by the human HER-2 gene independent of the epidermal_growth_factor_receptor .
11454885	0	epidermal_growth_factor_receptor	9,41	HER2	43,47	epidermal growth factor receptor	HER2	1956	2064	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	Value of epidermal_growth_factor_receptor , HER2 , p53 , and steroid receptors in predicting the efficacy of tamoxifen in high-risk postmenopausal breast_cancer patients .
15026342	0	epidermal_growth_factor_receptor	27,59	Her-4	97,102	epidermal growth factor receptor	Her-4	1956	2066	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cell surface expression of epidermal_growth_factor_receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma .
18986301	0	epidermal_growth_factor_receptor	56,88	HspBP1	14,20	epidermal growth factor receptor	HspBP1	1956	23640	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Extracellular HspBP1 and Hsp72 synergistically activate epidermal_growth_factor_receptor .
21467228	0	epidermal_growth_factor_receptor	21,53	INK4A	66,71	epidermal growth factor receptor	INK4A	1956	1029	Gene	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	Relationship between epidermal_growth_factor_receptor status , p16 -LRB- INK4A -RRB- , and outcome in head_and_neck_squamous_cell_carcinoma .
17902048	0	epidermal_growth_factor_receptor	44,76	Insulin_receptor_substrate-1	0,28	epidermal growth factor receptor	Insulin receptor substrate-1	1956	3667	Gene	Gene	involvement|nmod|START_ENTITY involvement|amod|END_ENTITY	Insulin_receptor_substrate-1 involvement in epidermal_growth_factor_receptor and insulin-like growth factor receptor signalling : implication for Gefitinib -LRB- ` Iressa ' -RRB- response and resistance .
12169631	0	epidermal_growth_factor_receptor	38,70	Keren	0,5	epidermal growth factor receptor	Keren	37455(Tax:7227)	326198(Tax:7227)	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Keren , a new ligand of the Drosophila epidermal_growth_factor_receptor , undergoes two modes of cleavage .
8985387	0	epidermal_growth_factor_receptor	41,73	LMP1	19,23	epidermal growth factor receptor	LMP1	1956	9260	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Epstein-Barr_virus LMP1 induction of the epidermal_growth_factor_receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation .
9570524	0	epidermal_growth_factor_receptor	155,187	LMP1	120,124	epidermal growth factor receptor	LMP1	1956	9260	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression END_ENTITY|nmod|activation	A fusion of the EBV latent membrane protein-1 -LRB- LMP1 -RRB- transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal_growth_factor_receptor expression , nuclear factor-kappa B , and stress-activated protein kinase .
9570524	0	epidermal_growth_factor_receptor	155,187	LMP1	47,51	epidermal growth factor receptor	LMP1	1956	9260	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression LMP1|nmod|activation similar|xcomp|LMP1 transmembrane|ccomp|similar transmembrane|nsubj|fusion fusion|appos|END_ENTITY	A fusion of the EBV latent membrane protein-1 -LRB- LMP1 -RRB- transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal_growth_factor_receptor expression , nuclear factor-kappa B , and stress-activated protein kinase .
22676223	0	epidermal_growth_factor_receptor	38,70	Liver-intestine_cadherin	0,24	epidermal growth factor receptor	Liver-intestine cadherin	1956	1015	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Liver-intestine_cadherin induction by epidermal_growth_factor_receptor is associated with intestinal differentiation of gastric_cancer .
19530702	0	epidermal_growth_factor_receptor	52,84	MIF	44,47	epidermal growth factor receptor	MIF	1956	4282	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of macrophage_inhibitory_factor -LRB- MIF -RRB- by epidermal_growth_factor_receptor -LRB- EGFR -RRB- in the MCF10AT model of breast_cancer_progression .
11278868	0	epidermal_growth_factor_receptor	31,63	MUC1	11,15	epidermal growth factor receptor	MUC1	1956	4582	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transgenic MUC1 interacts with epidermal_growth_factor_receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland .
16082192	0	epidermal_growth_factor_receptor	62,94	MUC1	15,19	epidermal growth factor receptor	MUC1	1956	4582	Gene	Gene	expression|nmod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|Suppression Suppression|nmod|synthesis synthesis|compound|END_ENTITY	Suppression of MUC1 synthesis downregulates expression of the epidermal_growth_factor_receptor .
20406885	0	epidermal_growth_factor_receptor	56,88	MUC1	0,4	epidermal growth factor receptor	MUC1	13649(Tax:10090)	17829(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	MUC1 regulates nuclear localization and function of the epidermal_growth_factor_receptor .
22250084	0	epidermal_growth_factor_receptor	50,82	MUC1	18,22	epidermal growth factor receptor	MUC1	1956	4582	Gene	Gene	phosphorylated|nmod|START_ENTITY phosphorylated|nsubjpass|mucin mucin|compound|END_ENTITY	Membrane-tethered MUC1 mucin is phosphorylated by epidermal_growth_factor_receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88 .
22883469	0	epidermal_growth_factor_receptor	81,113	MicroRNA-133b	0,13	epidermal growth factor receptor	MicroRNA-133b	1956	442890	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-133b inhibits the growth of non-small-cell_lung_cancer by targeting the epidermal_growth_factor_receptor .
26617770	0	epidermal_growth_factor_receptor	123,155	MicroRNA-133b	0,13	epidermal growth factor receptor	MicroRNA-133b	1956	442890	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-133b inhibits proliferation and invasion of ovarian_cancer cells through Akt and Erk1/2 inactivation by targeting epidermal_growth_factor_receptor .
20044804	0	epidermal_growth_factor_receptor	52,84	Mitogen-inducible_gene-6	0,24	epidermal growth factor receptor	Mitogen-inducible gene-6	1956	54206	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Mitogen-inducible_gene-6 is a negative regulator of epidermal_growth_factor_receptor signaling in hepatocytes and human hepatocellular_carcinoma .
8596488	0	epidermal_growth_factor_receptor	13,45	Mullerian_inhibiting_substance	75,105	epidermal growth factor receptor	Mullerian inhibiting substance	1956	268	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Reduction of epidermal_growth_factor_receptor phosphorylation by activated Mullerian_inhibiting_substance is vanadate-sensitive .
14701753	0	epidermal_growth_factor_receptor	66,98	NF-kappaB	99,108	epidermal growth factor receptor	NF-kappaB	1956	4790	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Distinct domains in the SHP-2 phosphatase differentially regulate epidermal_growth_factor_receptor / NF-kappaB activation through Gab1 in glioblastoma cells .
18541671	0	epidermal_growth_factor_receptor	19,51	NF-kappaB	87,96	epidermal growth factor receptor	NF-kappaB	1956	4790	Gene	Gene	role|nmod|START_ENTITY role|acl|signaling signaling|xcomp|END_ENTITY	Essential role for epidermal_growth_factor_receptor in glutamate receptor signaling to NF-kappaB .
20337085	0	epidermal_growth_factor_receptor	133,165	Notch1	53,59	epidermal growth factor receptor	Notch1	1956	4851	Gene	Gene	Study|nmod|START_ENTITY Study|nmod|END_ENTITY	-LSB- Study on the effects of overexpression of exogenous Notch1 in tongue_squamous_cell_carcinoma cells on cell growth and expression of epidermal_growth_factor_receptor in vitro -RSB- .
22102727	0	epidermal_growth_factor_receptor	24,56	Nox1	0,4	epidermal growth factor receptor	Nox1	13649(Tax:10090)	237038(Tax:10090)	Gene	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	Nox1 transactivation of epidermal_growth_factor_receptor promotes N-cadherin shedding and smooth muscle cell migration .
18758819	0	epidermal_growth_factor_receptor	42,74	P53	149,152	epidermal growth factor receptor	P53	1956	7157	Gene	Gene	antibody|nmod|START_ENTITY antibody|nmod|END_ENTITY	In vitro effect of radiation , antibody to epidermal_growth_factor_receptor and Docetaxel in human head and neck squamous_carcinoma cells with mutant P53 and over-expressed EGFR .
23755891	0	epidermal_growth_factor_receptor	81,113	P53	0,3	epidermal growth factor receptor	P53	1956	7157	Gene	Gene	recycling|nmod|START_ENTITY upregulate|dobj|recycling upregulate|nsubj|mutations mutations|nummod|END_ENTITY	P53 mutations in triple_negative_breast_cancer upregulate endosomal recycling of epidermal_growth_factor_receptor -LRB- EGFR -RRB- increasing its oncogenic potency .
22816767	0	epidermal_growth_factor_receptor	47,79	Phafin_2	29,37	epidermal growth factor receptor	Phafin 2	1956	79666	Gene	Gene	degradation|compound|START_ENTITY mediates|dobj|degradation mediates|nsubj|END_ENTITY	The PtdIns3P-binding protein Phafin_2 mediates epidermal_growth_factor_receptor degradation by promoting endosome fusion .
24304721	0	epidermal_growth_factor_receptor	60,92	Phosphatidylinositol_3-Kinase	0,29	epidermal growth factor receptor	Phosphatidylinositol 3-Kinase	1956	5293	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Phosphatidylinositol_3-Kinase dependent upregulation of the epidermal_growth_factor_receptor upon Flotillin-1 depletion in breast_cancer cells .
12589790	0	epidermal_growth_factor_receptor	71,103	Protein_kinase_A	0,16	epidermal growth factor receptor	Protein kinase A	24329(Tax:10116)	25636(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	Protein_kinase_A mediates cAMP-induced tyrosine phosphorylation of the epidermal_growth_factor_receptor .
18667434	0	epidermal_growth_factor_receptor	19,51	Pyk2	61,65	epidermal growth factor receptor	Pyk2	1956	2185	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	The transactivated epidermal_growth_factor_receptor recruits Pyk2 to regulate Src kinase activity .
18307993	0	epidermal_growth_factor_receptor	35,67	RME-8	0,5	epidermal growth factor receptor	RME-8	1956	23317	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	RME-8 regulates trafficking of the epidermal_growth_factor_receptor .
12101233	0	epidermal_growth_factor_receptor	179,211	Ras-extracellular_signal-regulated_kinase	100,141	epidermal growth factor receptor	Ras-extracellular signal-regulated kinase	1956	5594	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	The UV -LRB- Ribotoxic -RRB- stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular_signal-regulated_kinase signaling cascade from the activated epidermal_growth_factor_receptor .
16401477	0	epidermal_growth_factor_receptor	21,53	Reg_IV	0,6	epidermal growth factor receptor	Reg IV	1956	83998	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Reg_IV activates the epidermal_growth_factor_receptor / Akt/AP -1 signaling pathway in colon_adenocarcinomas .
20890302	0	epidermal_growth_factor_receptor	75,107	Reversion-inducing_cysteine-rich_protein_with_Kazal_motifs	0,58	epidermal growth factor receptor	Reversion-inducing cysteine-rich protein with Kazal motifs	13649(Tax:10090)	53614(Tax:10090)	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	Reversion-inducing_cysteine-rich_protein_with_Kazal_motifs interferes with epidermal_growth_factor_receptor signaling .
16164598	0	epidermal_growth_factor_receptor	28,60	Rho	0,3	epidermal growth factor receptor	Rho	1956	6010	Gene	Gene	endocytosis|nmod|START_ENTITY mediates|dobj|endocytosis mediates|nsubj|END_ENTITY	Rho mediates endocytosis of epidermal_growth_factor_receptor through phosphorylation of endophilin A1 by Rho-kinase .
16278215	0	epidermal_growth_factor_receptor	69,101	RhoB	0,4	epidermal growth factor receptor	RhoB	1956	388	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal_growth_factor_receptor signaling .
15182504	0	epidermal_growth_factor_receptor	32,64	SPC-A-1	79,86	epidermal growth factor receptor	SPC-A-1	1956	27032	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	-LSB- Effects of RNA interference on epidermal_growth_factor_receptor expression in SPC-A-1 cells -RSB- .
15342401	0	epidermal_growth_factor_receptor	27,59	SRC	0,3	epidermal growth factor receptor	SRC	13649(Tax:10090)	20779(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY mediate|ccomp|ligand mediate|nsubj|kinases kinases|compound|END_ENTITY	SRC family kinases mediate epidermal_growth_factor_receptor ligand cleavage , proliferation , and invasion of head_and_neck_cancer cells .
15381832	0	epidermal_growth_factor_receptor	146,178	SRC	125,128	epidermal growth factor receptor	SRC	1956	6714	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Secretion of gastric mucus phospholipids in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal_growth_factor_receptor transactivation .
15985706	0	epidermal_growth_factor_receptor	129,161	SRC	108,111	epidermal growth factor receptor	SRC	1956	6714	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Gastric mucin secretion in response to beta-adrenergic G protein-coupled receptor activation is mediated by SRC kinase-dependent epidermal_growth_factor_receptor transactivation .
7561890	0	epidermal_growth_factor_receptor	52,84	Schwannoma-derived_growth_factor	0,32	epidermal growth factor receptor	Schwannoma-derived growth factor	1956	374	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Schwannoma-derived_growth_factor interacts with the epidermal_growth_factor_receptor .
25721765	0	epidermal_growth_factor_receptor	25,57	Selenoprotein_W	0,15	epidermal growth factor receptor	Selenoprotein W	1956	6415	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Selenoprotein_W controls epidermal_growth_factor_receptor surface expression , activation and degradation via receptor ubiquitination .
16540667	0	epidermal_growth_factor_receptor	147,179	Signal_transducer_and_activator_of_transcription_3	0,50	epidermal growth factor receptor	Signal transducer and activator of transcription 3	1956	6774	Gene	Gene	mutations|nmod|START_ENTITY effects|nmod|mutations required|nmod|effects required|nsubjpass|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 is required for the oncogenic effects of non-small-cell lung_cancer-associated mutations of the epidermal_growth_factor_receptor .
11274221	0	epidermal_growth_factor_receptor	62,94	Src	0,3	epidermal growth factor receptor	Src	13649(Tax:10090)	20779(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal_growth_factor_receptor -LRB- EGFR -RRB- but are not required for coupling to the mitogen-activated_protein -LRB- MAP -RRB- kinase signaling cascade .
11882594	0	epidermal_growth_factor_receptor	52,84	Src	34,37	epidermal growth factor receptor	Src	24329(Tax:10116)	83805(Tax:10116)	Gene	Gene	transactivation|compound|START_ENTITY signaling|nmod|transactivation END_ENTITY|acl|signaling	Increased angiotensin_II-mediated Src signaling via epidermal_growth_factor_receptor transactivation is associated with decreased C-terminal_Src_kinase activity in vascular smooth muscle cells from spontaneously hypertensive rats .
15110780	0	epidermal_growth_factor_receptor	111,143	Src	90,93	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal_growth_factor_receptor transactivation .
16532343	0	epidermal_growth_factor_receptor	100,132	Src	10,13	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	downstream|nmod|START_ENTITY signaling|dobj|downstream activation|acl|signaling induce|nmod|activation induce|nsubj|END_ENTITY	Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal_growth_factor_receptor in human gallbladder_adenocarcinoma cells .
18667434	0	epidermal_growth_factor_receptor	19,51	Src	78,81	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|regulate regulate|dobj|activity activity|compound|END_ENTITY	The transactivated epidermal_growth_factor_receptor recruits Pyk2 to regulate Src kinase activity .
18794807	0	epidermal_growth_factor_receptor	135,167	Src	14,17	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	involvement|nmod|START_ENTITY chemoresistance|dep|involvement reverts|dobj|chemoresistance reverts|nsubj|Inhibition Inhibition|nmod|kinase kinase|compound|END_ENTITY	Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic_carcinoma cells : an involvement of epidermal_growth_factor_receptor signaling .
23349873	0	epidermal_growth_factor_receptor	36,68	Src	134,137	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	transactivation|nmod|START_ENTITY involves|nsubj|transactivation involves|dobj|oxidation oxidation|nmod|END_ENTITY	ATP-mediated transactivation of the epidermal_growth_factor_receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17 .
25338626	0	epidermal_growth_factor_receptor	59,91	Src	53,56	epidermal growth factor receptor	Src	13649(Tax:10090)	20779(Tax:10090)	Gene	Gene	species|dep|START_ENTITY species|dep|activation activation|nmod|END_ENTITY	Reactive oxygen species - mediated activation of the Src - epidermal_growth_factor_receptor - Akt signaling cascade prevents bortezomib - induced apoptosis in hepatocellular_carcinoma cells .
7608194	0	epidermal_growth_factor_receptor	31,63	Src	131,134	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	requirements|nmod|START_ENTITY substrates|nsubj|requirements substrates|xcomp|lacking lacking|xcomp|domains domains|nsubj|SH2 SH2|compound|END_ENTITY	Structural requirements of the epidermal_growth_factor_receptor for tyrosine phosphorylation of eps8 and eps15 , substrates lacking Src SH2 homology domains .
7797556	0	epidermal_growth_factor_receptor	27,59	Src	0,3	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Src phosphorylation of the epidermal_growth_factor_receptor at novel sites mediates receptor interaction with Src and P85_alpha .
7797556	0	epidermal_growth_factor_receptor	27,59	Src	110,113	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|nsubj|phosphorylation mediates|nmod|END_ENTITY	Src phosphorylation of the epidermal_growth_factor_receptor at novel sites mediates receptor interaction with Src and P85_alpha .
9374500	0	epidermal_growth_factor_receptor	84,116	Src	27,30	epidermal growth factor receptor	Src	1956	6714	Gene	Gene	internalization|nmod|START_ENTITY enhances|dobj|internalization enhances|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal_growth_factor_receptor .
16261333	0	epidermal_growth_factor_receptor	85,117	Src_homology_2-containing_phosphotyrosine_phosphatase	0,53	epidermal growth factor receptor	Src homology 2-containing phosphotyrosine phosphatase	24329(Tax:10116)	25622(Tax:10116)	Gene	Gene	transactivation|compound|START_ENTITY regulates|dobj|transactivation regulates|nsubj|END_ENTITY	Src_homology_2-containing_phosphotyrosine_phosphatase regulates endothelin-1-induced epidermal_growth_factor_receptor transactivation in rat renal tubular cell NRK-52E .
26661905	0	epidermal_growth_factor_receptor	4,36	Stathmin_1	47,57	epidermal growth factor receptor	Stathmin 1	13649(Tax:10090)	16765(Tax:10090)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	The epidermal_growth_factor_receptor decreases Stathmin_1 and triggers catagen entry in the mouse .
22250084	0	epidermal_growth_factor_receptor	50,82	TLR5	130,134	epidermal growth factor receptor	TLR5	1956	7100	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Membrane-tethered MUC1 mucin is phosphorylated by epidermal_growth_factor_receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88 .
8513568	1	epidermal_growth_factor_receptor	107,139	TNM	170,173	epidermal growth factor receptor	TNM	1956	10178	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|nsubj|relationship	Its relationship to epidermal_growth_factor_receptor , estradiol_receptor and tumor TNM .
17311283	0	epidermal_growth_factor_receptor	62,94	Tenascin_cytotactin	0,19	epidermal growth factor receptor	Tenascin cytotactin	1956	3371	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Tenascin_cytotactin epidermal growth factor-like repeat binds epidermal_growth_factor_receptor with low affinity .
10976912	0	epidermal_growth_factor_receptor	64,96	Thyrotropin-releasing_hormone	0,29	epidermal growth factor receptor	Thyrotropin-releasing hormone	24329(Tax:10116)	25569(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Thyrotropin-releasing_hormone stimulates phosphorylation of the epidermal_growth_factor_receptor in GH3 pituitary cells .
10027766	0	epidermal_growth_factor_receptor	47,79	Transforming_growth_factor-alpha	0,32	epidermal growth factor receptor	Transforming growth factor-alpha	24329(Tax:10116)	24827(Tax:10116)	Gene	Gene	acting|nmod|START_ENTITY acting|amod|END_ENTITY	Transforming_growth_factor-alpha acting at the epidermal_growth_factor_receptor reduces infarct volume after permanent middle_cerebral_artery_occlusion in rats .
10082132	0	epidermal_growth_factor_receptor	70,102	Transforming_growth_factor-alpha	0,32	epidermal growth factor receptor	Transforming growth factor-alpha	1956	7124	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	Transforming_growth_factor-alpha short-circuits downregulation of the epidermal_growth_factor_receptor .
1805786	0	epidermal_growth_factor_receptor	46,78	Transforming_growth_factor-alpha	0,32	epidermal growth factor receptor	Transforming growth factor-alpha	1956	7124	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Transforming_growth_factor-alpha binds to the epidermal_growth_factor_receptor in gastric mucosa .
8453634	0	epidermal_growth_factor_receptor	123,155	Transforming_growth_factor-alpha	0,32	epidermal growth factor receptor	Transforming growth factor-alpha	1956	7124	Gene	Gene	gene|compound|START_ENTITY production|nmod|gene production|amod|END_ENTITY	Transforming_growth_factor-alpha production and autoinduction in a colorectal_carcinoma cell line -LRB- DiFi -RRB- with an amplified epidermal_growth_factor_receptor gene .
9127315	0	epidermal_growth_factor_receptor	34,66	Transforming_growth_factor-alpha	0,32	epidermal growth factor receptor	Transforming growth factor-alpha	1956	7124	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-alpha , epidermal_growth_factor_receptor , and MiB-1 expression in Barrett 's - associated neoplasia : correlation with prognosis .
16585207	0	epidermal_growth_factor_receptor	64,96	Transforming_growth_factor_alpha	0,32	epidermal growth factor receptor	Transforming growth factor alpha	1956	7124	Gene	Gene	activation|amod|START_ENTITY constitutive|dobj|activation constitutive|nsubj|drives drives|compound|END_ENTITY	Transforming_growth_factor_alpha expression drives constitutive epidermal_growth_factor_receptor pathway activation and sensitivity to gefitinib -LRB- Iressa -RRB- in human pancreatic_cancer cell lines .
8605103	0	epidermal_growth_factor_receptor	112,144	Transforming_growth_factor_alpha	0,32	epidermal growth factor receptor	Transforming growth factor alpha	1956	7124	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Transforming_growth_factor_alpha and epidermal_growth_factor levels in bladder_cancer and their relationship to epidermal_growth_factor_receptor .
1504015	0	epidermal_growth_factor_receptor	65,97	Transforming_growth_factor_beta	0,31	epidermal growth factor receptor	Transforming growth factor beta	1956	7040	Gene	Gene	phosphorylation|nmod|START_ENTITY modulates|dobj|phosphorylation modulates|nsubj|END_ENTITY	Transforming_growth_factor_beta modulates phosphorylation of the epidermal_growth_factor_receptor and proliferation of A431 cells .
7556448	0	epidermal_growth_factor_receptor	46,78	Transforming_growth_factor_beta	0,31	epidermal growth factor receptor	Transforming growth factor beta	1956	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Transforming_growth_factor_beta regulation of epidermal_growth_factor_receptor in ectocervical epithelial cells .
19124464	0	epidermal_growth_factor_receptor	28,60	Tyrosine_kinase	0,15	epidermal growth factor receptor	Tyrosine kinase	1956	7294	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Tyrosine_kinase activity of epidermal_growth_factor_receptor is regulated by GM3 binding through carbohydrate to carbohydrate interactions .
24445050	0	epidermal_growth_factor_receptor	19,51	UBE1L	72,77	epidermal growth factor receptor	UBE1L	1956	7318	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of epidermal_growth_factor_receptor by curcumin-induced UBE1L in human bronchial epithelial cells .
16651443	0	epidermal_growth_factor_receptor	72,104	Y-box_binding_protein-1	18,41	epidermal growth factor receptor	Y-box binding protein-1	1956	4904	Gene	Gene	suppression|nmod|START_ENTITY results|nmod|suppression results|nsubj|Disruption Disruption|nmod|END_ENTITY	Disruption of the Y-box_binding_protein-1 results in suppression of the epidermal_growth_factor_receptor and HER-2 .
17595327	0	epidermal_growth_factor_receptor	197,229	Y-box_binding_protein-1	159,182	epidermal growth factor receptor	Y-box binding protein-1	1956	4904	Gene	Gene	inducing|dobj|START_ENTITY END_ENTITY|advcl|inducing	The phosphoinositide-dependent kinase-1 inhibitor 2-amino-N - -LSB- 4 - -LSB- 5 - -LRB- 2-phenanthrenyl -RRB- -3 - -LRB- trifluoromethyl -RRB- -1 H-pyrazol-1-yl -RSB- phenyl -RSB- - acetamide -LRB- OSU-03012 -RRB- prevents Y-box_binding_protein-1 from inducing epidermal_growth_factor_receptor .
24211838	0	epidermal_growth_factor_receptor	26,58	YBX1	82,86	epidermal growth factor receptor	YBX1	1956	4904	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Loss of CDH1 up-regulates epidermal_growth_factor_receptor via phosphorylation of YBX1 in non-small_cell_lung_cancer cells .
17548638	0	epidermal_growth_factor_receptor	48,80	amphiregulin	201,213	epidermal growth factor receptor	amphiregulin	1956	374	Gene	Gene	transactivation|compound|START_ENTITY signaling|nsubj|transactivation signaling|nmod|cells cells|nmod|release release|nmod|END_ENTITY	Macrophage-inflammatory_protein-3alpha mediates epidermal_growth_factor_receptor transactivation and ERK1/2 MAPK signaling in Caco-2 colonic epithelial cells via metalloproteinase-dependent release of amphiregulin .
18634036	0	epidermal_growth_factor_receptor	4,36	amphiregulin	44,56	epidermal growth factor receptor	amphiregulin	13649(Tax:10090)	11839(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|participates participates|nsubj|END_ENTITY	The epidermal_growth_factor_receptor ligand amphiregulin participates in the development of mouse liver_fibrosis .
19815304	0	epidermal_growth_factor_receptor	4,36	amphiregulin	44,56	epidermal growth factor receptor	amphiregulin	13649(Tax:10090)	11839(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|ccomp|regulator regulator|nsubj|END_ENTITY	The epidermal_growth_factor_receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression .
20803614	0	epidermal_growth_factor_receptor	60,92	amphiregulin	19,31	epidermal growth factor receptor	amphiregulin	1956	374	Gene	Gene	patients|nmod|START_ENTITY expression|nmod|patients expression|compound|END_ENTITY	Clinical impact of amphiregulin expression in patients with epidermal_growth_factor_receptor -LRB- EGFR -RRB- wild-type nonsmall_cell_lung_cancer treated with EGFR-tyrosine kinase inhibitors .
7679104	1	epidermal_growth_factor_receptor	157,189	amphiregulin	115,127	epidermal growth factor receptor	amphiregulin	1956	374	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|Evidence Evidence|dep|END_ENTITY	Evidence that amphiregulin acts exclusively through the epidermal_growth_factor_receptor at the surface of human epithelial cells .
9542658	0	epidermal_growth_factor_receptor	95,127	amphiregulin	14,26	epidermal growth factor receptor	amphiregulin	1956	374	Gene	Gene	colocalization|nmod|START_ENTITY Topography|dep|colocalization Topography|nmod|expression expression|compound|END_ENTITY	Topography of amphiregulin expression in cultured human keratinocytes : colocalization with the epidermal_growth_factor_receptor and CD44 .
15288768	0	epidermal_growth_factor_receptor	42,74	androgen_receptor	4,21	epidermal growth factor receptor	androgen receptor	1956	367	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	The androgen_receptor associates with the epidermal_growth_factor_receptor in androgen-sensitive_prostate_cancer cells .
21712088	0	epidermal_growth_factor_receptor	19,51	angiotensin_II	85,99	epidermal growth factor receptor	angiotensin II	24329(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Transactivation of epidermal_growth_factor_receptor by enhanced levels of endogenous angiotensin_II contributes to the overexpression of Gia proteins in vascular smooth muscle cells from SHR .
25209444	0	epidermal_growth_factor_receptor	99,131	b-catenin	67,76	epidermal growth factor receptor	b-catenin	1956	1499	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Human_papillomavirus_16 oncoprotein regulates the translocation of b-catenin via the activation of epidermal_growth_factor_receptor .
19637492	0	epidermal_growth_factor_receptor	68,100	basic_fibroblast_growth_factor	11,41	epidermal growth factor receptor	basic fibroblast growth factor	1956	2247	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	-LSB- Effect of basic_fibroblast_growth_factor on the gene expression of epidermal_growth_factor_receptor by periodontal ligament cells in culture -RSB- .
8425916	0	epidermal_growth_factor_receptor	18,50	basic_fibroblast_growth_factor	54,84	epidermal growth factor receptor	basic fibroblast growth factor	24329(Tax:10116)	54250(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of the epidermal_growth_factor_receptor by basic_fibroblast_growth_factor .
10428778	0	epidermal_growth_factor_receptor	57,89	c-Cbl	19,24	epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	desensitization|nmod|START_ENTITY mediates|dobj|desensitization mediates|nsubj|finger finger|nmod|END_ENTITY	The RING finger of c-Cbl mediates desensitization of the epidermal_growth_factor_receptor .
10531381	0	epidermal_growth_factor_receptor	37,69	c-Cbl	102,107	epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	ubiquitination|nmod|START_ENTITY involves|nsubj|ubiquitination involves|dobj|interaction interaction|nmod|finger finger|amod|END_ENTITY	Ligand-induced ubiquitination of the epidermal_growth_factor_receptor involves the interaction of the c-Cbl RING finger and UbcH7 .
15465819	0	epidermal_growth_factor_receptor	46,78	c-Cbl	29,34	epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	guides|dobj|START_ENTITY guides|nsubj|activity activity|nmod|END_ENTITY	Ubiquitin ligase activity of c-Cbl guides the epidermal_growth_factor_receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment .
17695511	0	epidermal_growth_factor_receptor	7,39	c-Cbl	104,109	epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	undergoes|nsubj|START_ENTITY undergoes|nmod|diminished diminished|nmod|END_ENTITY	Mutant epidermal_growth_factor_receptor undergoes less protein degradation due to diminished binding to c-Cbl .
18316398	0	epidermal_growth_factor_receptor	52,84	c-Cbl	33,38	epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	downregulation|compound|START_ENTITY interplay|nmod|downregulation interplay|nmod|END_ENTITY	A tale of two Cbls : interplay of c-Cbl and Cbl-b in epidermal_growth_factor_receptor downregulation .
19173594	0	epidermal_growth_factor_receptor	90,122	c-Cbl	18,23	epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal_growth_factor_receptor .
7592693	0	epidermal_growth_factor_receptor	52,84	c-Cbl	39,44	epidermal growth factor receptor	c-Cbl	1956	867	Gene	Gene	Coupling|nmod|START_ENTITY Coupling|nmod|END_ENTITY	Coupling of the proto-oncogene product c-Cbl to the epidermal_growth_factor_receptor .
15923621	0	epidermal_growth_factor_receptor	65,97	c-Jun	38,43	epidermal growth factor receptor	c-Jun	1956	3725	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal_growth_factor_receptor expression and cancer cell proliferation .
9446590	0	epidermal_growth_factor_receptor	63,95	c-Jun_N-terminal_kinase	27,50	epidermal growth factor receptor	c-Jun N-terminal kinase	1956	5599	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Constitutive activation of c-Jun_N-terminal_kinase by a mutant epidermal_growth_factor_receptor .
11483589	0	epidermal_growth_factor_receptor	4,36	c-Src	104,109	epidermal growth factor receptor	c-Src	1956	6714	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	The epidermal_growth_factor_receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin .
12750372	0	epidermal_growth_factor_receptor	26,58	c-Src	0,5	epidermal growth factor receptor	c-Src	1956	6714	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	c-Src is activated by the epidermal_growth_factor_receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing_hormone in COS7 cells .
14760089	0	epidermal_growth_factor_receptor	4,36	c-Src	90,95	epidermal growth factor receptor	c-Src	1956	6714	Gene	Gene	ZD1839|amod|START_ENTITY suppresses|nsubj|ZD1839 suppresses|dobj|pathways pathways|amod|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- suppresses c-Src and Pak1 pathways and invasiveness of human cancer cells .
15143162	0	epidermal_growth_factor_receptor	58,90	c-Src	103,108	epidermal growth factor receptor	c-Src	1956	6714	Gene	Gene	phospholipase_C-epsilon|nmod|START_ENTITY stimulation|nmod|phospholipase_C-epsilon mediated|nsubj|stimulation mediated|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Rap2B-dependent stimulation of phospholipase_C-epsilon by epidermal_growth_factor_receptor mediated by c-Src phosphorylation of RasGRP3 .
7488034	0	epidermal_growth_factor_receptor	21,53	c-Src	0,5	epidermal growth factor receptor	c-Src	1956	6714	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Src phosphorylates epidermal_growth_factor_receptor on tyrosine 845 .
1349034	0	epidermal_growth_factor_receptor	87,119	c-erbB-2	52,60	epidermal growth factor receptor	c-erbB-2	1956	2064	Gene	Gene	oncoprotein|nmod|START_ENTITY oncoprotein|amod|END_ENTITY	Human breast_cancer : prognostic significance of the c-erbB-2 oncoprotein compared with epidermal_growth_factor_receptor , DNA ploidy , and conventional pathologic features .
7935468	0	epidermal_growth_factor_receptor	58,90	c-fos	14,19	epidermal growth factor receptor	c-fos	1956	2353	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|amod|END_ENTITY	Activation of c-fos gene expression by a kinase-deficient epidermal_growth_factor_receptor .
8845374	0	epidermal_growth_factor_receptor	32,64	c-src	95,100	epidermal growth factor receptor	c-src	1956	6714	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	In vitro phosphorylation of the epidermal_growth_factor_receptor autophosphorylation domain by c-src : identification of phosphorylation sites and c-src SH2 domain binding sites .
14960328	0	epidermal_growth_factor_receptor	41,73	calmodulin	11,21	epidermal growth factor receptor	calmodulin	1956	808	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Endogenous calmodulin interacts with the epidermal_growth_factor_receptor in living cells .
14662875	0	epidermal_growth_factor_receptor	109,141	cathepsin_B	61,72	epidermal growth factor receptor	cathepsin B	13649(Tax:10090)	13030(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	IL-8-mediated cell migration in endothelial cells depends on cathepsin_B activity and transactivation of the epidermal_growth_factor_receptor .
10086340	0	epidermal_growth_factor_receptor	15,47	cbl-b	0,5	epidermal growth factor receptor	cbl-b	1956	868	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	cbl-b inhibits epidermal_growth_factor_receptor signaling .
25225463	0	epidermal_growth_factor_receptor	14,46	cyclin_D1	113,122	epidermal growth factor receptor	cyclin D1	1956	595	Gene	Gene	epidermal|compound|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
15240878	0	epidermal_growth_factor_receptor	65,97	cyclin_G-associated_kinase	28,54	epidermal growth factor receptor	cyclin G-associated kinase	1956	2580	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The serine/threonine kinase cyclin_G-associated_kinase regulates epidermal_growth_factor_receptor signaling .
11910351	0	epidermal_growth_factor_receptor	54,86	cyclooxygenase-2	18,34	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Bile_acids induce cyclooxygenase-2 expression via the epidermal_growth_factor_receptor in a human cholangiocarcinoma cell line .
12684433	0	epidermal_growth_factor_receptor	59,91	cyclooxygenase-2	27,43	epidermal growth factor receptor	cyclooxygenase-2	13649(Tax:10090)	19225(Tax:10090)	Gene	Gene	ZD1839|compound|START_ENTITY inhibitor|nmod|ZD1839 inhibitor|amod|END_ENTITY	Combination of a selective cyclooxygenase-2 inhibitor with epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect .
15723947	0	epidermal_growth_factor_receptor	84,116	cyclooxygenase-2	18,34	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	expression|compound|START_ENTITY Overexpression|nmod|expression Overexpression|nmod|END_ENTITY	Overexpression of cyclooxygenase-2 in nasopharyngeal_carcinoma and association with epidermal_growth_factor_receptor expression .
15838264	0	epidermal_growth_factor_receptor	164,196	cyclooxygenase-2	24,40	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	transactivation|nmod|START_ENTITY involvement|nmod|transactivation evidence|nmod|involvement pathways|dep|evidence stimulates|nmod|pathways stimulates|dobj|expression expression|amod|END_ENTITY	Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian_cancer cells through multiple signaling pathways : evidence for involvement of transactivation of the epidermal_growth_factor_receptor .
15914620	0	epidermal_growth_factor_receptor	18,50	cyclooxygenase-2	119,135	epidermal growth factor receptor	cyclooxygenase-2	24329(Tax:10116)	29527(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY leads|nsubj|Activation leads|nmod|induction induction|nmod|END_ENTITY	Activation of the epidermal_growth_factor_receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2 .
21199607	0	epidermal_growth_factor_receptor	35,67	cyclooxygenase-2	97,113	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	expression|nmod|START_ENTITY Correlations|nmod|expression phosphorylated|nsubj|Correlations phosphorylated|dobj|variables variables|amod|END_ENTITY	Correlations between expression of epidermal_growth_factor_receptor -LRB- EGFR -RRB- , phosphorylated EGFR , cyclooxygenase-2 and clinicopathological variables and treatment outcomes in nasopharyngeal_carcinomas .
21435385	0	epidermal_growth_factor_receptor	65,97	cyclooxygenase-2	29,45	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	induce|nmod|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Divalent lead cations induce cyclooxygenase-2 gene expression by epidermal_growth_factor_receptor / nuclear factor-kappa B signaling in A431carcinoma cells .
22048943	0	epidermal_growth_factor_receptor	45,77	cyclooxygenase-2	27,43	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	1|amod|START_ENTITY 1|amod|END_ENTITY	Prognostic significance of cyclooxygenase-2 , epidermal_growth_factor_receptor 1 , and microvascular density in gastric_cancer .
23355539	0	epidermal_growth_factor_receptor	51,83	cyclooxygenase-2	19,35	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Lapatinib-mediated cyclooxygenase-2 expression via epidermal_growth_factor_receptor / HuR interaction enhances the aggressiveness of triple-negative breast_cancer cells .
23973650	0	epidermal_growth_factor_receptor	151,183	cyclooxygenase-2	13,29	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression by prostaglandin_E2 stimulation of the prostanoid_EP4_receptor via coupling to Gai and transactivation of the epidermal_growth_factor_receptor in HCA-7 human colon_cancer cells .
25225463	0	epidermal_growth_factor_receptor	14,46	cyclooxygenase-2	95,111	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	epidermal|compound|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
26464643	0	epidermal_growth_factor_receptor	21,53	cyclooxygenase-2	80,96	epidermal growth factor receptor	cyclooxygenase-2	1956	5743	Gene	Gene	Relationship|nmod|START_ENTITY mutation|nsubj|Relationship mutation|dobj|Level Level|amod|END_ENTITY	Relationship between epidermal_growth_factor_receptor -LRB- EGFR -RRB- mutation and serum cyclooxygenase-2 Level , and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small_cell_lung_cancer cells .
10216286	0	epidermal_growth_factor_receptor	36,68	cyclooxygenases_1_and_2	90,113	epidermal growth factor receptor	cyclooxygenases 1 and 2	1956	5742;5743	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|END_ENTITY	Growth stimulation and induction of epidermal_growth_factor_receptor by overexpression of cyclooxygenases_1_and_2 in human colon_carcinoma cells .
8723734	0	epidermal_growth_factor_receptor	63,95	cytochrome_P450	28,43	epidermal growth factor receptor	cytochrome P450	24329(Tax:10116)	25251(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of constitutive cytochrome_P450 gene expression by epidermal_growth_factor_receptor ligands in cultured rat hepatocytes .
10215623	0	epidermal_growth_factor_receptor	14,46	ebi	0,3	epidermal growth factor receptor	ebi	37455(Tax:7227)	33212(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	ebi regulates epidermal_growth_factor_receptor signaling pathways in Drosophila .
10770635	0	epidermal_growth_factor_receptor	119,151	epidermal_growth_factor	20,43	epidermal growth factor receptor	epidermal growth factor	13649(Tax:10090)	13645(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY expressing|dobj|levels lines|acl|expressing polyplex|nmod|lines polyplex|dep|Gene Gene|nmod|END_ENTITY	Gene delivery by an epidermal_growth_factor / DNA polyplex to small_cell_lung_cancer cell lines expressing low levels of epidermal_growth_factor_receptor .
11513601	0	epidermal_growth_factor_receptor	123,155	epidermal_growth_factor	92,115	epidermal growth factor receptor	epidermal growth factor	13649(Tax:10090)	13645(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Real-time kinetics of ligand/cell surface receptor interactions in living cells : binding of epidermal_growth_factor to the epidermal_growth_factor_receptor .
11746830	0	epidermal_growth_factor_receptor	110,142	epidermal_growth_factor	32,55	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	owing|compound|START_ENTITY overexpressing|dobj|owing lines|acl|overexpressing END_ENTITY|nmod|lines	Decreased mitogenic response to epidermal_growth_factor in human squamous_cell_carcinoma lines overexpressing epidermal_growth_factor_receptor owing to limiting amounts of the adaptor protein Grb2 : rescue by retinoic_acid treatment .
11889128	0	epidermal_growth_factor_receptor	51,83	epidermal_growth_factor	18,41	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	START_ENTITY|nsubj|recruits recruits|compound|END_ENTITY	Elastase-released epidermal_growth_factor recruits epidermal_growth_factor_receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts .
14690686	0	epidermal_growth_factor_receptor	155,187	epidermal_growth_factor	60,83	epidermal growth factor receptor	epidermal growth factor	13649(Tax:10090)	13645(Tax:10090)	Gene	Gene	application|nmod|START_ENTITY Preparation|dep|application Preparation|nmod|END_ENTITY	Preparation and characterization of Alexa_Fluor_594-labeled epidermal_growth_factor for fluorescence resonance energy transfer studies : application to the epidermal_growth_factor_receptor .
1691502	0	epidermal_growth_factor_receptor	6,38	epidermal_growth_factor	74,97	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	residue|compound|START_ENTITY cross-linked|nsubj|residue cross-linked|xcomp|END_ENTITY	Human epidermal_growth_factor_receptor residue covalently cross-linked to epidermal_growth_factor .
1847663	0	epidermal_growth_factor_receptor	95,127	epidermal_growth_factor	28,51	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Cellular growth response to epidermal_growth_factor in colon_carcinoma cells with an amplified epidermal_growth_factor_receptor derived from a familial_adenomatous_polyposis patient .
20187444	0	epidermal_growth_factor_receptor	105,137	epidermal_growth_factor	64,87	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of topical external administration of recombinant human epidermal_growth_factor on expression of epidermal_growth_factor_receptor and its mRNA in scald wound of diabetes_mellitus rat -RSB- .
2434521	0	epidermal_growth_factor_receptor	129,161	epidermal_growth_factor	52,75	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	levels|compound|START_ENTITY detected|dobj|levels function|parataxis|detected function|nmod|END_ENTITY	Induction of differentiated trophoblast function by epidermal_growth_factor : relation of immunohistochemically detected cellular epidermal_growth_factor_receptor levels .
25416211	0	epidermal_growth_factor_receptor	15,47	epidermal_growth_factor	70,93	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of epidermal_growth_factor_receptor and concentrations of epidermal_growth_factor and melatonin in endometrial_carcinoma -RSB- .
3015918	0	epidermal_growth_factor_receptor	80,112	epidermal_growth_factor	45,68	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Effects of protein kinase C activation after epidermal_growth_factor binding on epidermal_growth_factor_receptor phosphorylation .
3324824	0	epidermal_growth_factor_receptor	26,58	epidermal_growth_factor	112,135	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	detection|nmod|START_ENTITY detection|acl|using using|dobj|END_ENTITY	Western blot detection of epidermal_growth_factor_receptor from plasmalemma of culture cells using 125I-labeled epidermal_growth_factor .
6208480	0	epidermal_growth_factor_receptor	97,129	epidermal_growth_factor	11,34	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal_growth_factor_receptor in normal human fibroblasts .
8608180	0	epidermal_growth_factor_receptor	26,58	epidermal_growth_factor	80,103	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	radioligand|nmod|START_ENTITY radioligand|dep|111In 111In|acl|labeled labeled|dobj|END_ENTITY	A new radioligand for the epidermal_growth_factor_receptor : 111In labeled human epidermal_growth_factor derivatized with a bifunctional metal-chelating peptide .
8827569	0	epidermal_growth_factor_receptor	86,118	epidermal_growth_factor	10,33	epidermal growth factor receptor	epidermal growth factor	24329(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY transport|nmod|expression amino_acid|dobj|transport amino_acid|nsubj|Effect Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on placental amino_acid transport and regulation of epidermal_growth_factor_receptor expression of hepatocyte in rat .
9398212	0	epidermal_growth_factor_receptor	54,86	epidermal_growth_factor	105,128	epidermal growth factor receptor	epidermal growth factor	1956	1950	Gene	Gene	Persistence|nmod|START_ENTITY Persistence|nmod|absence absence|nmod|END_ENTITY	Persistence of dimerization and enzymatic activity of epidermal_growth_factor_receptor in the absence of epidermal_growth_factor .
23153706	0	epidermal_growth_factor_receptor	10,42	epidermal_growth_factor_receptor	49,81	epidermal growth factor receptor	epidermal growth factor receptor	1956	1956	Gene	Gene	Targeting|dobj|START_ENTITY END_ENTITY|dep|Targeting	Targeting epidermal_growth_factor_receptor / human epidermal_growth_factor_receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder_carcinoma .
23153706	0	epidermal_growth_factor_receptor	49,81	epidermal_growth_factor_receptor	10,42	epidermal growth factor receptor	epidermal growth factor receptor	1956	1956	Gene	Gene	START_ENTITY|dep|Targeting Targeting|dobj|END_ENTITY	Targeting epidermal_growth_factor_receptor / human epidermal_growth_factor_receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder_carcinoma .
20110044	0	epidermal_growth_factor_receptor	41,73	epidermal_growth_factor_receptor-2	84,118	epidermal growth factor receptor	epidermal growth factor receptor-2	1956	2064	Gene	Gene	kinases|compound|START_ENTITY kinases|amod|END_ENTITY	Lapatinib : a small-molecule inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor-2 tyrosine kinases used in the treatment of breast_cancer .
25866477	0	epidermal_growth_factor_receptor	28,60	epiregulin	14,24	epidermal growth factor receptor	epiregulin	1956	2069	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	The effect of epiregulin on epidermal_growth_factor_receptor expression and proliferation of oral_squamous_cell_carcinoma cell lines .
7608194	0	epidermal_growth_factor_receptor	31,63	eps8	96,100	epidermal growth factor receptor	eps8	1956	2059	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Structural requirements of the epidermal_growth_factor_receptor for tyrosine phosphorylation of eps8 and eps15 , substrates lacking Src SH2 homology domains .
2572319	0	epidermal_growth_factor_receptor	23,55	erbB-2	67,73	epidermal growth factor receptor	erbB-2	1956	2064	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Aberrant expression of epidermal_growth_factor_receptor and HER-2 -LRB- erbB-2 -RRB- messenger RNAs in human renal_cancers .
8105439	0	epidermal_growth_factor_receptor	25,57	erbB-2	58,64	epidermal growth factor receptor	erbB-2	1956	2064	Gene	Gene	terminus|nmod|START_ENTITY terminus|parataxis|internalization internalization|nsubjpass|chimerae chimerae|amod|END_ENTITY	The carboxyl terminus of epidermal_growth_factor_receptor / erbB-2 chimerae is internalization impaired .
9079690	0	epidermal_growth_factor_receptor	26,58	erbB-2	91,97	epidermal growth factor receptor	erbB-2	1956	2064	Gene	Gene	aspects|nmod|START_ENTITY required|nsubj|aspects required|nmod|transmodulation transmodulation|nmod|neu neu|amod|END_ENTITY	Structural aspects of the epidermal_growth_factor_receptor required for transmodulation of erbB-2 / neu .
26440329	0	epidermal_growth_factor_receptor	163,195	erbB2	204,209	epidermal growth factor receptor	erbB2	407217(Tax:9913)	505709(Tax:9913)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
17453948	0	epidermal_growth_factor_receptor	14,46	ezrin	48,53	epidermal growth factor receptor	ezrin	1956	7430	Gene	Gene	factor|compound|START_ENTITY factor|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , ezrin , hepatocyte growth factor , and c-Met in uveal_melanoma : an immunohistochemical study .
19254954	0	epidermal_growth_factor_receptor	70,102	glutathione_S-transferase_P1	38,66	epidermal growth factor receptor	glutathione S-transferase P1	1956	2950	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the human glutathione_S-transferase_P1 by epidermal_growth_factor_receptor .
18234969	0	epidermal_growth_factor_receptor	24,56	hepatocyte_growth_factor	71,95	epidermal growth factor receptor	hepatocyte growth factor	1956	3082	Gene	Gene	activation|nsubj|START_ENTITY activation|nmod|END_ENTITY	Transcription-dependent epidermal_growth_factor_receptor activation by hepatocyte_growth_factor .
22788954	0	epidermal_growth_factor_receptor	54,86	hepatocyte_growth_factor	20,44	epidermal growth factor receptor	hepatocyte growth factor	1956	3082	Gene	Gene	START_ENTITY|nsubj|mediates mediates|compound|END_ENTITY	Fibroblast-secreted hepatocyte_growth_factor mediates epidermal_growth_factor_receptor tyrosine kinase inhibitor resistance in triple-negative_breast_cancers through paracrine activation of Met .
17931419	0	epidermal_growth_factor_receptor	75,107	hypoxia-inducible_factor-1alpha	172,203	epidermal growth factor receptor	hypoxia-inducible factor-1alpha	1956	3091	Gene	Gene	cells|nmod|START_ENTITY Responses|nmod|cells linked|nsubjpass|Responses linked|nmod|downregulation downregulation|nmod|END_ENTITY	Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal_growth_factor_receptor -LRB- EGFR -RRB- to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible_factor-1alpha .
21640718	0	epidermal_growth_factor_receptor	5,37	insulin-like_growth_factor-1_receptor	45,82	epidermal growth factor receptor	insulin-like growth factor-1 receptor	1956	3480	Gene	Gene	/|nsubj|START_ENTITY /|dobj|inhibitor inhibitor|amod|END_ENTITY	Dual epidermal_growth_factor_receptor -LRB- EGFR -RRB- / insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitor : a novel approach for overcoming resistance in anticancer treatment .
1361720	0	epidermal_growth_factor_receptor	34,66	interferon_gamma	14,30	epidermal growth factor receptor	interferon gamma	1956	3458	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	The effect of interferon_gamma on epidermal_growth_factor_receptor expression in normal and malignant ovarian epithelial cells .
12515612	0	epidermal_growth_factor_receptor	77,109	latent_membrane_protein_1	18,43	epidermal growth factor receptor	latent membrane protein 1	1956	9260	Gene	Gene	phosphorylation|nmod|START_ENTITY modulates|dobj|phosphorylation modulates|nsubj|END_ENTITY	-LSB- EB virus encoded latent_membrane_protein_1 modulates the phosphorylation of epidermal_growth_factor_receptor in nasopharyngeal_carcinoma cell line -RSB- .
15652339	0	epidermal_growth_factor_receptor	24,56	latent_membrane_protein_1	124,149	epidermal growth factor receptor	latent membrane protein 1	1956	9260	Gene	Gene	accumulation|nmod|START_ENTITY stage|nsubj|accumulation stage|nmod|END_ENTITY	Nuclear accumulation of epidermal_growth_factor_receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent_membrane_protein_1 .
17881446	0	epidermal_growth_factor_receptor	13,45	latent_membrane_protein_1	79,104	epidermal growth factor receptor	latent membrane protein 1	1956	9260	Gene	Gene	expression|compound|START_ENTITY expression|nmod|region region|compound|END_ENTITY	Induction of epidermal_growth_factor_receptor expression by Epstein-Barr_virus latent_membrane_protein_1 C-terminal-activating region 1 is mediated by NF-kappaB_p50 homodimer/Bcl -3 complexes .
18367518	0	epidermal_growth_factor_receptor	71,103	latent_membrane_protein_1	19,44	epidermal growth factor receptor	latent membrane protein 1	1956	9260	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 induces expression of the epidermal_growth_factor_receptor through effects on Bcl-3 and STAT3 .
20410275	0	epidermal_growth_factor_receptor	138,170	latent_membrane_protein_1	19,44	epidermal growth factor receptor	latent membrane protein 1	1956	9260	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression pathways|acl|regulate NF|dep|pathways NF|amod|distinctive distinctive|nmod:npmod|modulates modulates|nummod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 modulates distinctive NF - kappaB pathways through C-terminus-activating region 1 to regulate epidermal_growth_factor_receptor expression .
22581837	0	epidermal_growth_factor_receptor	8,40	latent_membrane_protein_1	161,186	epidermal growth factor receptor	latent membrane protein 1	1956	9260	Gene	Gene	interacts|compound|START_ENTITY triggered|nsubj|interacts triggered|nmod|END_ENTITY	Nuclear epidermal_growth_factor_receptor interacts with transcriptional_intermediary_factor_2 to activate cyclin_D1 gene expression triggered by the oncoprotein latent_membrane_protein_1 .
19530702	0	epidermal_growth_factor_receptor	52,84	macrophage_inhibitory_factor	14,42	epidermal growth factor receptor	macrophage inhibitory factor	1956	4282	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of macrophage_inhibitory_factor -LRB- MIF -RRB- by epidermal_growth_factor_receptor -LRB- EGFR -RRB- in the MCF10AT model of breast_cancer_progression .
24573489	0	epidermal_growth_factor_receptor	82,114	miR-7	0,5	epidermal growth factor receptor	miR-7	1956	10859	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	miR-7 inhibits the invasion and metastasis of gastric_cancer cells by suppressing epidermal_growth_factor_receptor expression .
15797859	0	epidermal_growth_factor_receptor	43,75	p38	0,3	epidermal growth factor receptor	p38	1956	1432	Gene	Gene	transactivation|nmod|START_ENTITY transactivation|amod|END_ENTITY	p38 kinase-mediated transactivation of the epidermal_growth_factor_receptor is required for dedifferentiation of renal epithelial cells after oxidant injury .
10621852	0	epidermal_growth_factor_receptor	65,97	p53	26,29	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	neu|dep|START_ENTITY neu|compound|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
10870681	0	epidermal_growth_factor_receptor	80,112	p53	165,168	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	expression|appos|START_ENTITY analysis|nmod|expression oncogene|nsubj|analysis oncogene|iobj|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
11299733	0	epidermal_growth_factor_receptor	34,66	p53	120,123	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	Overexpression|nmod|START_ENTITY associated|nsubjpass|Overexpression associated|nmod|induction induction|compound|END_ENTITY	Overexpression of deletion-mutant epidermal_growth_factor_receptor is associated with altered genotoxic stress-provoked p53 mRNA induction in a human glioblastoma cell line .
11546792	0	epidermal_growth_factor_receptor	28,60	p53	0,3	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|p63 p63|compound|END_ENTITY	p53 Homologue p63 represses epidermal_growth_factor_receptor expression .
1355662	0	epidermal_growth_factor_receptor	80,112	p53	0,3	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	expression|nmod|START_ENTITY relationship|nmod|expression expression|dep|relationship expression|compound|END_ENTITY	p53 protein expression in human breast_carcinoma : relationship to expression of epidermal_growth_factor_receptor , c-erbB-2 protein overexpression , and oestrogen receptor .
14670624	0	epidermal_growth_factor_receptor	105,137	p53	7,10	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	level|nmod|START_ENTITY correlation|nmod|level protein|dep|correlation protein|compound|END_ENTITY	Mutant p53 protein in the serum of patients with cervical_carcinoma : correlation with the level of serum epidermal_growth_factor_receptor and prognostic significance .
16632243	0	epidermal_growth_factor_receptor	133,165	p53	7,10	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	level|nmod|START_ENTITY Correlation|nmod|level protein|dep|Correlation protein|compound|END_ENTITY	Mutant p53 protein in the serum of patients with colorectal_cancer : Correlation with the level of carcinoembryonic_antigen and serum epidermal_growth_factor_receptor .
17404024	0	epidermal_growth_factor_receptor	4,36	p53	160,163	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	ZD1839|amod|START_ENTITY suppresses|nsubj|ZD1839 suppresses|dobj|proliferation proliferation|nmod|cells cells|nmod|independent independent|compound|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- suppresses proliferation and invasion of human oral squamous_carcinoma cells via p53 independent and MMP , uPAR dependent mechanism .
18359760	0	epidermal_growth_factor_receptor	39,71	p53	80,83	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	transcription|nmod|START_ENTITY regulates|dobj|transcription regulates|nmod|END_ENTITY	Notch-1 regulates transcription of the epidermal_growth_factor_receptor through p53 .
18391986	0	epidermal_growth_factor_receptor	20,52	p53	8,11	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	activity|compound|START_ENTITY induces|dobj|activity induces|nsubj|Loss Loss|nmod|END_ENTITY	Loss of p53 induces epidermal_growth_factor_receptor promoter activity in normal human keratinocytes .
19716156	0	epidermal_growth_factor_receptor	84,116	p53	118,121	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	status|dep|START_ENTITY status|dep|END_ENTITY	Caveolin-1 expression in diffuse_gliomas : correlation with the proliferation index , epidermal_growth_factor_receptor , p53 , and_1p / 19q status .
25225463	0	epidermal_growth_factor_receptor	14,46	p53	48,51	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	epidermal|compound|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
26820293	0	epidermal_growth_factor_receptor	74,106	p53	138,141	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	up-regulation|nmod|START_ENTITY promoted|nmod|up-regulation promoted|nmod|domain domain|compound|END_ENTITY	Addiction of lung_cancer cells to GOF p53 is promoted by up-regulation of epidermal_growth_factor_receptor through multiple contacts with p53 transactivation domain and promoter .
26820293	0	epidermal_growth_factor_receptor	74,106	p53	38,41	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	up-regulation|nmod|START_ENTITY promoted|nmod|up-regulation promoted|nsubjpass|Addiction Addiction|nmod|cells cells|nmod|GOF GOF|nummod|END_ENTITY	Addiction of lung_cancer cells to GOF p53 is promoted by up-regulation of epidermal_growth_factor_receptor through multiple contacts with p53 transactivation domain and promoter .
7911025	0	epidermal_growth_factor_receptor	64,96	p53	33,36	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	START_ENTITY|nsubj|detection detection|nmod|protein protein|compound|END_ENTITY	Immunohistochemical detection of p53 protein , c-erbB-2 protein , epidermal_growth_factor_receptor protein and proliferating_cell_nuclear_antigen in gastric_carcinoma .
7911031	0	epidermal_growth_factor_receptor	14,46	p53	134,137	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|bladder_cancer bladder_cancer|nmod|expression expression|dep|c-erbB-2 c-erbB-2|appos|END_ENTITY	Expression of epidermal_growth_factor_receptor in bladder_cancer as related to established prognostic factors , oncoprotein -LRB- c-erbB-2 , p53 -RRB- expression and long-term prognosis .
8152794	0	epidermal_growth_factor_receptor	40,72	p53	16,19	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Wild-type human p53 activates the human epidermal_growth_factor_receptor promoter .
8280379	0	epidermal_growth_factor_receptor	34,66	p53	15,18	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	overexpression|compound|START_ENTITY mutations|nmod|overexpression mutations|compound|END_ENTITY	Correlation of p53 mutations with epidermal_growth_factor_receptor overexpression and absence of mdm2 amplification in human esophageal_carcinomas .
8887630	0	epidermal_growth_factor_receptor	40,72	p53	91,94	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Transcriptional activation of the human epidermal_growth_factor_receptor promoter by human p53 .
9819502	0	epidermal_growth_factor_receptor	69,101	p53	64,67	epidermal growth factor receptor	p53	1956	7157	Gene	Gene	immunostaining|dep|START_ENTITY immunostaining|compound|END_ENTITY	Prognostic evaluation in supratentorial_astrocytic_tumors using p53 , epidermal_growth_factor_receptor , c-erbB-2 immunostaining .
11546792	0	epidermal_growth_factor_receptor	28,60	p63	14,17	epidermal growth factor receptor	p63	1956	8626	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	p53 Homologue p63 represses epidermal_growth_factor_receptor expression .
12782800	0	epidermal_growth_factor_receptor	14,46	p63	67,70	epidermal growth factor receptor	p63	1956	8626	Gene	Gene	signaling|compound|START_ENTITY Inhibition|nmod|signaling decreases|nsubj|Inhibition decreases|dobj|expression expression|amod|END_ENTITY	Inhibition of epidermal_growth_factor_receptor signaling decreases p63 expression in head and neck squamous_carcinoma cells .
23207846	0	epidermal_growth_factor_receptor	39,71	p63	34,37	epidermal growth factor receptor	p63	1956	8626	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of p63 , epidermal_growth_factor_receptor -LRB- EGFR -RRB- and notch-1 in radicular_cysts , dentigerous_cysts_and_keratocystic_odontogenic_tumors .
10870681	0	epidermal_growth_factor_receptor	80,112	p65	74,77	epidermal growth factor receptor	p65	1956	5970	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
8119714	0	epidermal_growth_factor_receptor	4,36	phospholipase_C-gamma_1	56,79	epidermal growth factor receptor	phospholipase C-gamma 1	1956	5335	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The epidermal_growth_factor_receptor is associated with phospholipase_C-gamma_1 in meningiomas .
12009895	0	epidermal_growth_factor_receptor	92,124	phospholipid_scramblase_1	16,41	epidermal growth factor receptor	phospholipid scramblase 1	1956	5359	Gene	Gene	enriched|nmod|START_ENTITY enriched|nsubjpass|END_ENTITY	Plasma membrane phospholipid_scramblase_1 is enriched in lipid rafts and interacts with the epidermal_growth_factor_receptor .
12871937	0	epidermal_growth_factor_receptor	97,129	phospholipid_scramblase_1	16,41	epidermal growth factor receptor	phospholipid scramblase 1	13649(Tax:10090)	22038(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Plasma membrane phospholipid_scramblase_1 promotes EGF-dependent activation of c-Src through the epidermal_growth_factor_receptor .
8655964	0	epidermal_growth_factor_receptor	115,147	proliferating_cell_nuclear_antigen	22,56	epidermal growth factor receptor	proliferating cell nuclear antigen	24329(Tax:10116)	25737(Tax:10116)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|nmod|END_ENTITY	The overexpression of proliferating_cell_nuclear_antigen in biliary_cirrhosis in the rat and its relationship with epidermal_growth_factor_receptor .
19201881	0	epidermal_growth_factor_receptor	52,84	prostaglandin_E2	98,114	epidermal growth factor receptor	Cyclooxygenase 2	1956	5743	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Lipopolysaccharide initiates a positive feedback of epidermal_growth_factor_receptor signaling by prostaglandin_E2 in human biliary_carcinoma cells .
23973650	0	epidermal_growth_factor_receptor	151,183	prostanoid_EP4_receptor	80,103	epidermal growth factor receptor	prostanoid EP4 receptor	1956	5734	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 expression by prostaglandin_E2 stimulation of the prostanoid_EP4_receptor via coupling to Gai and transactivation of the epidermal_growth_factor_receptor in HCA-7 human colon_cancer cells .
17942932	0	epidermal_growth_factor_receptor	15,47	protein_kinase_C-alpha	61,83	epidermal growth factor receptor	protein kinase C-alpha	1956	5578	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|amod|END_ENTITY	Suppression of epidermal_growth_factor_receptor signaling by protein_kinase_C-alpha activation requires CD82 , caveolin-1 , and ganglioside .
12873986	0	epidermal_growth_factor_receptor	119,151	signal_transducer_and_activator_of_transcription_3	39,89	epidermal growth factor receptor	signal transducer and activator of transcription 3	1956	6774	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|sites sites|amod|END_ENTITY	Identification and characterization of signal_transducer_and_activator_of_transcription_3 recruitment sites within the epidermal_growth_factor_receptor .
18586824	0	epidermal_growth_factor_receptor	8,40	signal_transducer_and_activator_of_transcription_5	63,113	epidermal growth factor receptor	signal transducer and activator of transcription 5	1956	6776	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nuclear epidermal_growth_factor_receptor -LRB- EGFR -RRB- interacts with signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- in activating Aurora-A gene expression .
19047094	0	epidermal_growth_factor_receptor	160,192	signal_transducer_and_activator_of_transcription_5	27,77	epidermal growth factor receptor	signal transducer and activator of transcription 5	1956	6776	Gene	Gene	contributes|xcomp|START_ENTITY contributes|nsubj|activation activation|nmod|END_ENTITY	Constitutive activation of signal_transducer_and_activator_of_transcription_5 contributes to tumor growth , epithelial-mesenchymal transition , and resistance to epidermal_growth_factor_receptor targeting .
2106069	0	epidermal_growth_factor_receptor	14,46	src	74,77	epidermal growth factor receptor	src	24329(Tax:10116)	83805(Tax:10116)	Gene	Gene	biosynthesis|compound|START_ENTITY Inhibition|nmod|biosynthesis caused|nsubj|Inhibition caused|nmod|product product|compound|END_ENTITY	Inhibition of epidermal_growth_factor_receptor biosynthesis caused by the src oncogene product , pp60v-src .
22581837	0	epidermal_growth_factor_receptor	8,40	transcriptional_intermediary_factor_2	56,93	epidermal growth factor receptor	transcriptional intermediary factor 2	1956	10499	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Nuclear epidermal_growth_factor_receptor interacts with transcriptional_intermediary_factor_2 to activate cyclin_D1 gene expression triggered by the oncoprotein latent_membrane_protein_1 .
12202486	0	epidermal_growth_factor_receptor	23,55	transforming_growth_factor-alpha	131,163	epidermal growth factor receptor	transforming growth factor-alpha	1956	7124	Gene	Gene	Transactivation|nmod|START_ENTITY requires|nsubj|Transactivation requires|dobj|release release|nmod|END_ENTITY	Transactivation of the epidermal_growth_factor_receptor in colonic epithelial cells by carbachol requires extracellular release of transforming_growth_factor-alpha .
12944410	0	epidermal_growth_factor_receptor	72,104	transforming_growth_factor-alpha	39,71	epidermal growth factor receptor	transforming growth factor-alpha	1956	7124	Gene	Gene	growth|dep|START_ENTITY activates|dep|growth activates|dobj|END_ENTITY	Hypoxia inducible factor activates the transforming_growth_factor-alpha / epidermal_growth_factor_receptor growth stimulatory pathway in VHL -LRB- - / - -RRB- renal_cell_carcinoma cells .
8702723	0	epidermal_growth_factor_receptor	4,36	transforming_growth_factor-alpha	45,77	epidermal growth factor receptor	transforming growth factor-alpha	13649(Tax:10090)	21802(Tax:10090)	Gene	Gene	couples|nsubj|START_ENTITY couples|dobj|factor factor|amod|END_ENTITY	The epidermal_growth_factor_receptor couples transforming_growth_factor-alpha , heparin-binding epidermal growth factor-like factor , and amphiregulin to Neu , ErbB-3 , and ErbB-4 .
3496959	0	epidermal_growth_factor_receptor	14,46	transforming_growth_factor-beta	66,97	epidermal growth factor receptor	transforming growth factor-beta	1956	7040	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Modulation of epidermal_growth_factor_receptor gene expression by transforming_growth_factor-beta in a human breast_carcinoma cell line .
10436007	0	epidermal_growth_factor_receptor	76,108	transforming_growth_factor_alpha	29,61	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|release release|nmod|END_ENTITY	Radiation-induced release of transforming_growth_factor_alpha activates the epidermal_growth_factor_receptor and mitogen-activated protein kinase pathway in carcinoma cells , leading to increased proliferation and protection from radiation-induced cell death .
10621852	0	epidermal_growth_factor_receptor	65,97	transforming_growth_factor_alpha	31,63	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	neu|dep|START_ENTITY neu|dep|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
10924142	0	epidermal_growth_factor_receptor	90,122	transforming_growth_factor_alpha	48,80	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Real-time kinetic studies on the interaction of transforming_growth_factor_alpha with the epidermal_growth_factor_receptor extracellular domain reveal a conformational change model .
11522647	0	epidermal_growth_factor_receptor	67,99	transforming_growth_factor_alpha	100,132	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	association|nmod|START_ENTITY kinases|dep|association kinases|dep|expression expression|compound|END_ENTITY	Activated extracellular signal-regulated kinases : association with epidermal_growth_factor_receptor / transforming_growth_factor_alpha expression in head and neck squamous_carcinoma and inhibition by anti-epidermal_growth_factor_receptor treatments .
12297049	0	epidermal_growth_factor_receptor	33,65	transforming_growth_factor_alpha	96,128	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	domain|compound|START_ENTITY structure|nmod|domain bound|nsubj|structure bound|nmod|END_ENTITY	Crystal structure of a truncated epidermal_growth_factor_receptor extracellular domain bound to transforming_growth_factor_alpha .
1390737	0	epidermal_growth_factor_receptor	63,95	transforming_growth_factor_alpha	23,55	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Multidomain binding of transforming_growth_factor_alpha to the epidermal_growth_factor_receptor .
14519647	0	epidermal_growth_factor_receptor	135,167	transforming_growth_factor_alpha	102,134	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	autocrine|compound|START_ENTITY signaling|nsubj|autocrine Responsiveness|parataxis|signaling Responsiveness|acl|retinoid retinoid|nmod|abrogation abrogation|nmod|END_ENTITY	Responsiveness to the retinoic_acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming_growth_factor_alpha / epidermal_growth_factor_receptor autocrine signaling in head and neck squamous_carcinoma cells .
1677800	1	epidermal_growth_factor_receptor	152,184	transforming_growth_factor_alpha	119,151	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	pathways|nsubj|START_ENTITY Inhibition|parataxis|pathways Inhibition|nmod|effects effects|nmod|END_ENTITY	Inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming_growth_factor_alpha / epidermal_growth_factor_receptor pathways .
1718591	0	epidermal_growth_factor_receptor	48,80	transforming_growth_factor_alpha	15,47	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	mechanism|amod|START_ENTITY Involvement|dep|mechanism Involvement|nmod|END_ENTITY	Involvement of transforming_growth_factor_alpha / epidermal_growth_factor_receptor autocrine growth mechanism in an ovarian_cancer cell line in vitro .
1933859	0	epidermal_growth_factor_receptor	47,79	transforming_growth_factor_alpha	14,46	epidermal growth factor receptor	transforming growth factor alpha	13649(Tax:10090)	21802(Tax:10090)	Gene	Gene	mechanism|amod|START_ENTITY Importance|dep|mechanism Importance|nmod|END_ENTITY	Importance of transforming_growth_factor_alpha / epidermal_growth_factor_receptor autocrine growth mechanism in an ovarian_cancer cell line in vivo .
7519440	0	epidermal_growth_factor_receptor	112,144	transforming_growth_factor_alpha	79,111	epidermal growth factor receptor	transforming growth factor alpha	24329(Tax:10116)	24827(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY alpha|dep|receptors END_ENTITY|dep|alpha	Hepatic regeneration in vitamin_A-deficient rats : changes in the expression of transforming_growth_factor_alpha / epidermal_growth_factor_receptor and retinoic_acid receptors alpha and beta .
7728756	0	epidermal_growth_factor_receptor	134,166	transforming_growth_factor_alpha	10,42	epidermal growth factor receptor	transforming growth factor alpha	13649(Tax:10090)	21802(Tax:10090)	Gene	Gene	ligands|compound|START_ENTITY involvement|nmod|ligands neoplasia|dep|involvement dispensible|nmod|neoplasia dispensible|nsubj|END_ENTITY	Autocrine transforming_growth_factor_alpha is dispensible for v-rasHa-induced epidermal neoplasia : potential involvement of alternate epidermal_growth_factor_receptor ligands .
7829492	0	epidermal_growth_factor_receptor	104,136	transforming_growth_factor_alpha	20,52	epidermal growth factor receptor	transforming growth factor alpha	396494(Tax:9031)	414743(Tax:9031)	Gene	Gene	binding|nmod|START_ENTITY beta-sheet|nmod|binding B-loop|xcomp|beta-sheet B-loop|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of the transforming_growth_factor_alpha B-loop beta-sheet to binding and activation of the epidermal_growth_factor_receptor .
7947089	0	epidermal_growth_factor_receptor	118,150	transforming_growth_factor_alpha	85,117	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Autocrine stimulation of a human lung_mesothelioma cell line is mediated through the transforming_growth_factor_alpha / epidermal_growth_factor_receptor mitogenic pathway .
8879184	0	epidermal_growth_factor_receptor	101,133	transforming_growth_factor_alpha	39,71	epidermal growth factor receptor	transforming growth factor alpha	13649(Tax:10090)	21802(Tax:10090)	Gene	Gene	Reversal_of_lung_lesions|nmod|START_ENTITY Reversal_of_lung_lesions|nmod|mice mice|compound|END_ENTITY	Reversal_of_lung_lesions in transgenic transforming_growth_factor_alpha mice by expression of mutant epidermal_growth_factor_receptor .
9100135	0	epidermal_growth_factor_receptor	25,57	transforming_growth_factor_alpha	74,106	epidermal growth factor receptor	transforming growth factor alpha	24329(Tax:10116)	24827(Tax:10116)	Gene	Gene	ontogeny|nmod|START_ENTITY ontogeny|appos|END_ENTITY	Prenatal ontogeny of the epidermal_growth_factor_receptor and its ligand , transforming_growth_factor_alpha , in the rat brain .
9399568	0	epidermal_growth_factor_receptor	113,145	transforming_growth_factor_alpha	16,48	epidermal growth factor receptor	transforming growth factor alpha	1956	7124	Gene	Gene	binders|nmod|START_ENTITY library|nmod|binders phage|dobj|library phage|nsubj|Construction Construction|nmod|END_ENTITY	Construction of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- phage library and identification of high binders of epidermal_growth_factor_receptor -LRB- EGFR -RRB- by phage display .
11834172	0	epidermal_growth_factor_receptor	31,63	transforming_growth_factor_beta	65,96	epidermal growth factor receptor	transforming growth factor beta	1956	7040	Gene	Gene	oncogene|compound|START_ENTITY oncogene|dep|END_ENTITY	-LSB- Significance of expression of epidermal_growth_factor_receptor , transforming_growth_factor_beta , c-erbB-2 oncogene in myoepithelioma of salivary gland -RSB- .
2613750	0	epidermal_growth_factor_receptor	71,103	transforming_growth_factor_beta	112,143	epidermal growth factor receptor	transforming growth factor beta	1956	7040	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Modulation of transforming_growth_factor_alpha-dependent expression of epidermal_growth_factor_receptor gene by transforming_growth_factor_beta , triiodothyronine , and retinoic_acid .
7986746	0	epidermal_growth_factor_receptor	13,45	transforming_growth_factor_beta_1	68,101	epidermal growth factor receptor	transforming growth factor beta 1	24329(Tax:10116)	59086(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Induction of epidermal_growth_factor_receptor gene transcription by transforming_growth_factor_beta_1 : association with loss of protein binding to a negative regulatory element .
9699517	0	epidermal_growth_factor_receptor	26,58	ts13	99,103	epidermal growth factor receptor	ts13	1956	7896	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	CCG1/TAF -LRB- II -RRB- 250 regulates epidermal_growth_factor_receptor gene transcription in cell cycle mutant ts13 .
12065843	0	epidermal_growth_factor_receptor	54,86	vIII	31,35	epidermal growth factor receptor	vIII	1956	1351	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	A new antibody recognizing the vIII mutation of human epidermal_growth_factor_receptor .
25225463	0	epidermal_growth_factor_receptor	14,46	vascular_endothelial_growth_factor	59,93	epidermal growth factor receptor	vascular endothelial growth factor	1956	7422	Gene	Gene	epidermal|compound|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
7533293	0	epidermal_growth_factor_receptor	18,50	waved-2	54,61	epidermal growth factor receptor	waved-2	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	A mutation in the epidermal_growth_factor_receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired_lactation .
11167085	0	epidermal_growth_factor_receptor-2	23,57	HER2	59,63	epidermal growth factor receptor-2	HER2	2064	2064	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The value of the human epidermal_growth_factor_receptor-2 -LRB- HER2 -RRB- as a prognostic marker .
11342194	0	epidermal_growth_factor_receptor-2	23,57	HER2	59,63	epidermal growth factor receptor-2	HER2	2064	2064	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The value of the human epidermal_growth_factor_receptor-2 -LRB- HER2 -RRB- as a prognostic marker .
20110044	0	epidermal_growth_factor_receptor-2	84,118	epidermal_growth_factor_receptor	41,73	epidermal growth factor receptor-2	epidermal growth factor receptor	2064	1956	Gene	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Lapatinib : a small-molecule inhibitor of epidermal_growth_factor_receptor and human epidermal_growth_factor_receptor-2 tyrosine kinases used in the treatment of breast_cancer .
21062982	0	epidermal_growth_factor_receptor_2	32,66	DMP1	18,22	epidermal growth factor receptor 2	DMP1	2064	1758	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Critical roles of DMP1 in human epidermal_growth_factor_receptor_2 / neu-Arf-p53 signaling and breast_cancer development .
23379971	0	epidermal_growth_factor_receptor_2	71,105	HER2	107,111	epidermal growth factor receptor 2	HER2	2064	2064	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Validation of a new classifier for the automated analysis of the human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- gene amplification in breast_cancer specimens .
23744760	0	epidermal_growth_factor_receptor_2	14,48	HER2	50,54	epidermal growth factor receptor 2	HER2	2064	2064	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Soluble human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- levels in patients with HER2-positive breast_cancer receiving chemotherapy with or without trastuzumab : results from North Central Cancer Treatment Group adjuvant trial N9831 .
24393876	0	epidermal_growth_factor_receptor_2	36,70	HER2	72,76	epidermal growth factor receptor 2	HER2	2064	2064	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	-LSB- Clinical significance of the human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- in patients with recurrent gastric_cancer who received S-1 adjuvant chemotherapy -RSB- .
16467118	0	epidermal_growth_factor_receptor_2	49,83	Progesterone_receptor	0,21	epidermal growth factor receptor 2	Progesterone receptor	2064	5241	Gene	Gene	overexpression|amod|START_ENTITY correlates|nmod|overexpression correlates|nsubj|loss loss|amod|END_ENTITY	Progesterone_receptor loss correlates with human epidermal_growth_factor_receptor_2 overexpression in estrogen_receptor-positive breast_cancer .
25412937	0	epidermal_growth_factor_receptor_2	74,108	VEGF	44,48	epidermal growth factor receptor 2	VEGF	2064	7422	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	The single nucleotide polymorphism +936 _ C/T VEGF is associated with human epidermal_growth_factor_receptor_2 expression in Moroccan breast_cancer women .
17308086	0	epidermal_growth_factor_receptor_2	6,40	angiopoietin-2	51,65	epidermal growth factor receptor 2	angiopoietin-2	2064	285	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Human epidermal_growth_factor_receptor_2 regulates angiopoietin-2 expression in breast_cancer via AKT and mitogen-activated protein kinase pathways .
26448177	0	epidermal_growth_factor_receptor_2	90,124	neu	125,128	epidermal growth factor receptor 2	neu	2064	2064	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Loss of FOXO1 promotes gastric_tumour growth and metastasis through upregulation of human epidermal_growth_factor_receptor_2 / neu expression .
19620495	0	epidermal_growth_factor_receptor_2	48,82	progesterone_receptor	19,40	epidermal growth factor receptor 2	progesterone receptor	2064	5241	Gene	Gene	Estrogen_receptor|appos|START_ENTITY Estrogen_receptor|appos|END_ENTITY	Estrogen_receptor , progesterone_receptor , human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- , and epidermal_growth_factor_receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic_breast_cancer .
24351599	0	epidermal_growth_factor_receptor_2	67,101	progesterone_receptor	35,56	epidermal growth factor receptor 2	progesterone receptor	2064	5241	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- Reliability of estrogen_receptor , progesterone_receptor and human epidermal_growth_factor_receptor_2 expression in breast_cancer evaluated by immunohistochemistry -RSB- .
9703936	0	epidermal_growth_factor_receptor_family_proteins	14,62	EGFR	64,68	epidermal growth factor receptor family proteins	EGFR	1956	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor_family_proteins -LRB- EGFR , c-erbB-2 and c-erbB-3 -RRB- in gastric_cancer and chronic_gastritis .
21357683	0	epidermal_growth_factor_substrate_8	65,100	c-Jun_N-terminal_kinase_2	0,25	epidermal growth factor substrate 8	c-Jun N-terminal kinase 2	2059	5601	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	c-Jun_N-terminal_kinase_2 -LRB- JNK2 -RRB- enhances cell migration through epidermal_growth_factor_substrate_8 -LRB- EPS8 -RRB- .
20923448	0	epilysin	44,52	MMP-28	54,60	epilysin	MMP-28	79148	79148	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nicotine modulates gelatinase B -LRB- MMP-9 -RRB- and epilysin -LRB- MMP-28 -RRB- expression in reconstituted human oral epithelium .
18277055	0	epimorphin	110,120	syntaxin_2	99,109	epimorphin	syntaxin 2	13852(Tax:10090)	13852(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	A new ENU-induced mutant mouse with defective spermatogenesis caused by a nonsense mutation of the syntaxin_2 / epimorphin -LRB- Stx2/Epim -RRB- gene .
23549083	0	epiregulin	25,35	ERK	92,95	epiregulin	ERK	13874(Tax:10090)	26413(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Tumor fibroblast-derived epiregulin promotes growth of colitis-associated_neoplasms through ERK .
23074094	0	epiregulin	17,27	FBXL11	56,62	epiregulin	FBXL11	2069	22992	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Demethylation of epiregulin gene by histone demethylase FBXL11 and BCL6_corepressor inhibits osteo/dentinogenic differentiation .
17274952	0	epiregulin	48,58	Insulin	0,7	epiregulin	Insulin	2069	3630	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Insulin induces a transcriptional activation of epiregulin , HB-EGF and amphiregulin , by a PI3K-dependent mechanism : identification of a specific insulin-responsive promoter element .
16192470	0	epiregulin	82,92	aryl_hydrocarbon_receptor	4,29	epiregulin	aryl hydrocarbon receptor	59325(Tax:10116)	25690(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor directly regulates expression of the potent mitogen epiregulin .
25866477	0	epiregulin	14,24	epidermal_growth_factor_receptor	28,60	epiregulin	epidermal growth factor receptor	2069	1956	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of epiregulin on epidermal_growth_factor_receptor expression and proliferation of oral_squamous_cell_carcinoma cell lines .
9930070	0	episialin	6,15	EGFR	76,80	episialin	EGFR	4582	1956	Gene	Gene	expression|compound|START_ENTITY independent|nsubj|expression independent|nmod|expression expression|compound|END_ENTITY	MUC1 -LRB- episialin -RRB- expression in non-small_cell_lung_cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients .
9930070	0	episialin	6,15	MUC1	0,4	episialin	MUC1	4582	4582	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MUC1 -LRB- episialin -RRB- expression in non-small_cell_lung_cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients .
1958179	0	episialin	10,19	Muc1	21,25	episialin	Muc1	17829(Tax:10090)	17829(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse episialin -LRB- Muc1 -RRB- gene and its promoter : rapid evolution of the repetitive domain in the protein .
27066515	0	episodic_ataxia_type_2	70,92	CACNA1A	44,51	episodic ataxia type 2	CACNA1A	773	773	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Next-generation sequencing identifies novel CACNA1A gene mutations in episodic_ataxia_type_2 .
11226248	0	epithelial_cadherin	31,50	Presenilin-1	0,12	epithelial cadherin	Presenilin-1	12550(Tax:10090)	19164(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Presenilin-1 binds cytoplasmic epithelial_cadherin , inhibits cadherin/p120 association , and regulates stability and function of the cadherin/catenin adhesion complex .
9839166	0	epithelial_cadherin	75,94	vascular-endothelial_cadherin	33,62	epithelial cadherin	vascular-endothelial cadherin	999	1003	Gene	Gene	presence|nmod|START_ENTITY presence|nmod|END_ENTITY	Epithelioid_sarcoma : presence of vascular-endothelial_cadherin and lack of epithelial_cadherin .
16651558	0	epithelial_calcium_channel	32,58	ECaC	60,64	epithelial calcium channel	ECaC	100136177(Tax:8022)	100136177(Tax:8022)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of a branchial epithelial_calcium_channel -LRB- ECaC -RRB- in freshwater rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
10585755	0	epithelial_cell_adhesion_molecule	30,63	EP-CAM	65,71	epithelial cell adhesion molecule	EP-CAM	17075(Tax:10090)	17075(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abnormal thymic expression of epithelial_cell_adhesion_molecule -LRB- EP-CAM -RRB- in New Zealand Black -LRB- NZB -RRB- mice .
25060911	0	epithelial_cell_adhesion_molecule	31,64	EPCAM	66,71	epithelial cell adhesion molecule	EPCAM	4072	4072	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Clinical significance of serum epithelial_cell_adhesion_molecule -LRB- EPCAM -RRB- levels in patients with lung_cancer .
16678891	0	epithelial_cell_adhesion_molecule	18,51	Ep-CAM	53,59	epithelial cell adhesion molecule	Ep-CAM	4072	4072	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of epithelial_cell_adhesion_molecule -LRB- Ep-CAM -RRB- is an independent prognostic marker for reduced survival of patients with epithelial_ovarian_cancer .
24906438	0	epithelial_cell_adhesion_molecule	22,55	EpCAM	57,62	epithelial cell adhesion molecule	EpCAM	4072	4072	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	The overexpression of epithelial_cell_adhesion_molecule -LRB- EpCAM -RRB- in glioma .
15613858	0	epithelial_cell_adhesion_molecule	14,47	EpCam	49,54	epithelial cell adhesion molecule	EpCam	4072	4072	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of epithelial_cell_adhesion_molecule -LRB- EpCam -RRB- in renal_epithelial_tumors .
23667256	0	epithelial_cell_adhesion_molecule	37,70	Epcam	30,35	epithelial cell adhesion molecule	Epcam	406454(Tax:7955)	406454(Tax:7955)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Zeb1 regulates E-cadherin and Epcam -LRB- epithelial_cell_adhesion_molecule -RRB- expression to control cell behavior in early zebrafish development .
11505407	0	epithelial_cell_adhesion_molecule	100,133	Tumor_necrosis_factor_alpha	0,27	epithelial cell adhesion molecule	Tumor necrosis factor alpha	4072	7124	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha negatively regulates the expression of the carcinoma-associated antigen epithelial_cell_adhesion_molecule .
8566052	0	epithelial_cell_adhesion_molecule	50,83	gp40	14,18	epithelial cell adhesion molecule	gp40	4072	17075(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Expression of gp40 , the murine homologue of human epithelial_cell_adhesion_molecule -LRB- Ep-CAM -RRB- , by murine dendritic cells .
22517003	0	epithelial_cellular_adhesion_molecule	33,70	EpCAM	72,77	epithelial cellular adhesion molecule	EpCAM	4072	4072	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	-LSB- Detection and clinical value of epithelial_cellular_adhesion_molecule -LRB- EpCAM -RRB- mRNA positive circulating tumor cells in metastatic breast_cancer -RSB- .
22517003	0	epithelial_cellular_adhesion_molecule	33,70	tumor	105,110	epithelial cellular adhesion molecule	EpCAM	4072	4072	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	-LSB- Detection and clinical value of epithelial_cellular_adhesion_molecule -LRB- EpCAM -RRB- mRNA positive circulating tumor cells in metastatic breast_cancer -RSB- .
14703768	0	epithelial_growth_factor_receptor	11,44	EGFR	46,50	epithelial growth factor receptor	EGFR	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of epithelial_growth_factor_receptor -LRB- EGFR -RRB- kinase inhibitors on genetically reconstituted mouse mammary glands .
23046633	0	epithelial_growth_factor_receptor	18,51	EGFR	53,57	epithelial growth factor receptor	EGFR	1956	1956	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of epithelial_growth_factor_receptor -LRB- EGFR -RRB- predicts better response to neo-adjuvant chemotherapy in patients with triple-negative breast_cancer .
22631659	0	epithelial_growth_factor_receptor	105,138	tumor_necrosis_factor-alpha-induced_protein_8	14,59	epithelial growth factor receptor	tumor necrosis factor-alpha-induced protein 8	1956	25816	Gene	Gene	levels|compound|START_ENTITY Expression|nmod|levels Expression|nmod|END_ENTITY	Expression of tumor_necrosis_factor-alpha-induced_protein_8 in pancreas tissues and its correlation with epithelial_growth_factor_receptor levels .
9989799	0	epithelial_microtubule-associated_protein_of_115_kDa	46,98	E-MAP-115	35,44	epithelial microtubule-associated protein of 115 kDa	E-MAP-115	9053	9053	Gene	Gene	Upregulation|dep|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation and redistribution of E-MAP-115 -LRB- epithelial_microtubule-associated_protein_of_115_kDa -RRB- in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts .
18928407	0	epithelial_sodium_channel	18,43	ENaC	45,49	epithelial sodium channel	ENaC	20276(Tax:10090)	20276(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of the epithelial_sodium_channel -LRB- ENaC -RRB- by serine proteases .
21944177	0	epithelial_sodium_channel	52,77	angiotensin_II	11,25	epithelial sodium channel	angiotensin II	24768(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of angiotensin_II on expression of alveolar epithelial_sodium_channel in rat -RSB- .
14556084	0	epithelial_sodium_channels	17,43	ENaC	45,49	epithelial sodium channels	ENaC	24768(Tax:10116)	24768(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Putative role of epithelial_sodium_channels -LRB- ENaC -RRB- in the afferent limb of cardio renal reflexes in rats .
9883583	0	epithelial_v-like_antigen	26,51	Eva	53,56	epithelial v-like antigen	Eva	14012(Tax:10090)	14012(Tax:10090)	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Expression pattern of the epithelial_v-like_antigen -LRB- Eva -RRB- transcript suggests a possible role in placental morphogenesis .
16137571	0	epm1	32,36	cystatin_B	38,48	epm1	cystatin B	25308(Tax:10116)	25308(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cell-specific expression of the epm1 -LRB- cystatin_B -RRB- gene in developing rat cerebellum .
15683029	0	epoetin	43,50	epoetin	66,73	epoetin	epoetin	2056	2056	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Change of EPO treatment from subcutaneous epoetin to intravenous epoetin or darbepoetin alpha -RSB- .
15683029	0	epoetin	66,73	epoetin	43,50	epoetin	epoetin	2056	2056	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Change of EPO treatment from subcutaneous epoetin to intravenous epoetin or darbepoetin alpha -RSB- .
8557749	0	eps15	30,35	AP-2	98,102	eps15	AP-2	2060	7020	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The tyrosine kinase substrate eps15 is constitutively associated with the plasma membrane adaptor AP-2 .
7532293	0	eps8	18,22	EGFR	54,58	eps8	EGFR	2059	1956	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Direct binding of eps8 to the juxtamembrane domain of EGFR is phosphotyrosine - and SH2-independent .
7608194	0	eps8	96,100	epidermal_growth_factor_receptor	31,63	eps8	epidermal growth factor receptor	2059	1956	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Structural requirements of the epidermal_growth_factor_receptor for tyrosine phosphorylation of eps8 and eps15 , substrates lacking Src SH2 homology domains .
20534429	0	epsilon-COP	47,58	alpha-COP	21,30	epsilon-COP	alpha-COP	11316	1314	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat .
8445652	0	epsilon-crystallin	29,47	lactate_dehydrogenase_B	5,28	epsilon-crystallin	lactate dehydrogenase B	101801152	101801152	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	Duck lactate_dehydrogenase_B / epsilon-crystallin gene .
17941087	0	equilibrative_nucleoside_transporter	38,74	ENT1	78,82	equilibrative nucleoside transporter	ENT1	63997(Tax:10116)	63997(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High glucose suppresses expression of equilibrative_nucleoside_transporter 1 -LRB- ENT1 -RRB- in rat cardiac fibroblasts through a mechanism dependent on PKC-zeta and MAP kinases .
19164463	0	equilibrative_nucleoside_transporter_1	16,54	ENT1	56,60	equilibrative nucleoside transporter 1	ENT1	2030	2030	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the equilibrative_nucleoside_transporter_1 -LRB- ENT1 -RRB- in transport and metabolism of ribavirin by human and wild-type or Ent1 - / - mouse erythrocytes .
21678404	0	equilibrative_nucleoside_transporter_1	22,60	hENT1	62,67	equilibrative nucleoside transporter 1	hENT1	2030	2030	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	New role of the human equilibrative_nucleoside_transporter_1 -LRB- hENT1 -RRB- in epithelial-to-mesenchymal transition in renal tubular cells .
23393003	0	era	51,54	JAK2	58,62	era	JAK2	26284	3717	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Diagnosis and therapy of polycythemia_vera in the era of JAK2 -RSB- .
23929182	0	era	21,24	tumor_necrosis_factor_alpha	28,55	era	tumor necrosis factor alpha	26284	7124	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Leishmaniasis in the era of tumor_necrosis_factor_alpha antagonist therapy -- a research agenda for Europe .
25068025	0	erbB	13,17	Neuregulin-1	0,12	erbB	Neuregulin-1	1956	3084	Gene	Gene	activities|amod|START_ENTITY END_ENTITY|dep|activities	Neuregulin-1 / erbB activities with focus on the susceptibility of the heart to anthracyclines .
14654929	0	erbB-1	25,31	Androgen_receptor	0,17	erbB-1	Androgen receptor	1956	367	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Androgen_receptor versus erbB-1 and erbB-2 expression in human prostate_neoplasms .
10765127	0	erbB-2	58,64	HER-2	65,70	erbB-2	HER-2	2064	2064	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Vitamin_D_receptor gene BsmI polymorphism correlates with erbB-2 / HER-2 expression in human rectal_cancer .
1681519	0	erbB-2	57,63	HER2	64,68	erbB-2	HER2	2064	2064	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	G to A polymorphism at amino_acid codon 655 of the human erbB-2 / HER2 gene .
19106626	0	erbB-2	49,55	HER2	43,47	erbB-2	HER2	2064	2064	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	The antidiabetic drug metformin suppresses HER2 -LRB- erbB-2 -RRB- oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast_carcinoma cells .
8102855	0	erbB-2	0,6	Her-2	7,12	erbB-2	Her-2	2064	2064	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	erbB-2 / Her-2 gene amplification and overexpression in parotid gland tumors .
15870086	0	erbB-2	218,224	Her2/neu	208,216	erbB-2	Her2/neu	2064	2064	Gene	Gene	oncogene|dep|START_ENTITY oncogene|compound|END_ENTITY	Antitumoral actions of the anti-obesity drug orlistat -LRB- XenicalTM -RRB- in breast_cancer cells : blockade of cell cycle progression , promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu -LRB- erbB-2 -RRB- oncogene .
2572319	0	erbB-2	67,73	epidermal_growth_factor_receptor	23,55	erbB-2	epidermal growth factor receptor	2064	1956	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Aberrant expression of epidermal_growth_factor_receptor and HER-2 -LRB- erbB-2 -RRB- messenger RNAs in human renal_cancers .
8105439	0	erbB-2	58,64	epidermal_growth_factor_receptor	25,57	erbB-2	epidermal growth factor receptor	2064	1956	Gene	Gene	chimerae|amod|START_ENTITY internalization|nsubjpass|chimerae terminus|parataxis|internalization terminus|nmod|END_ENTITY	The carboxyl terminus of epidermal_growth_factor_receptor / erbB-2 chimerae is internalization impaired .
9079690	0	erbB-2	91,97	epidermal_growth_factor_receptor	26,58	erbB-2	epidermal growth factor receptor	2064	1956	Gene	Gene	neu|amod|START_ENTITY transmodulation|nmod|neu required|nmod|transmodulation required|nsubj|aspects aspects|nmod|END_ENTITY	Structural aspects of the epidermal_growth_factor_receptor required for transmodulation of erbB-2 / neu .
1677443	0	erbB-2	47,53	neu	54,57	erbB-2	neu	2064	2064	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Cloning , expression , and biological effects of erbB-2 / neu gene in mammalian cells .
8001930	0	erbB-2	12,18	p53	0,3	erbB-2	p53	2064	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	p53 but not erbB-2 expression is associated with rapid tumor proliferation in urinary bladder_cancer .
10762642	0	erbB-2	31,37	p90	46,49	erbB-2	p90	2064	57650	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells .
20951118	0	erbB-3	46,52	sclerostin	65,75	erbB-3	sclerostin	13867(Tax:10090)	74499(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Sclerostin-erbB-3 interactions : modulation of erbB-3 activity by sclerostin .
2218496	0	erbB2	39,44	EGF_receptor	71,83	erbB2	EGF receptor	2064	1956	Gene	Gene	product|amod|START_ENTITY ligand|nmod|product interaction|nmod|ligand interaction|nmod|END_ENTITY	Direct interaction of a ligand for the erbB2 oncogene product with the EGF_receptor and p185erbB2 .
17043217	0	erbB2	0,5	G_protein-coupled_receptor	22,48	erbB2	G protein-coupled receptor	2064	10663	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	erbB2 is required for G_protein-coupled_receptor signaling in the heart .
26440329	0	erbB2	204,209	IGF-1R	254,260	erbB2	IGF-1R	505709(Tax:9913)	281848(Tax:9913)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
26440329	0	erbB2	204,209	epidermal_growth_factor_receptor	163,195	erbB2	epidermal growth factor receptor	505709(Tax:9913)	407217(Tax:9913)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
26440329	0	erbB2	204,209	heparin-binding_epidermal_growth_factor-like_growth_factor	95,153	erbB2	heparin-binding epidermal growth factor-like growth factor	505709(Tax:9913)	522921(Tax:9913)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
26440329	0	erbB2	204,209	matrix_metalloproteinases_2_and_9	44,77	erbB2	matrix metalloproteinases 2 and 9	505709(Tax:9913)	282872(Tax:9913)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
21439954	0	erbB3	78,83	EGFR	43,47	erbB3	EGFR	2065	1956	Gene	Gene	interacting|nmod|START_ENTITY signaling|advcl|interacting END_ENTITY|acl|signaling	Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines .
15375338	0	erbB3	14,19	ErbB2	0,5	erbB3	ErbB2	2065	2064	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	ErbB2 without erbB3 expression in metaplastic columnar epithelium of Barrett 's _ esophagus .
16714539	0	erbin	9,14	Nod2	42,46	erbin	Nod2	55914	64127	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|activation activation|nmod|END_ENTITY	Role for erbin in bacterial activation of Nod2 .
18501646	0	erythroblast-macrophage_protein	16,47	Emp	49,52	erythroblast-macrophage protein	Emp	59003(Tax:10090)	59003(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|appos|END_ENTITY	Requirement for erythroblast-macrophage_protein -LRB- Emp -RRB- in definitive erythropoiesis .
9587054	0	erythrocyte_ankyrin	33,52	Anion_exchanger_2	0,17	erythrocyte ankyrin	Anion exchanger 2	286	6522	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Anion_exchanger_2 -LRB- AE2 -RRB- binds to erythrocyte_ankyrin and is colocalized with ankyrin along the basolateral plasma membrane of human gastric parietal cells .
3903517	0	erythroid-potentiating_activity	77,108	tissue_inhibitor_of_metalloproteinases	18,56	erythroid-potentiating activity	tissue inhibitor of metalloproteinases	7076	7076	Gene	Gene	Sequence|nmod|START_ENTITY Sequence|nmod|END_ENTITY	Sequence of human tissue_inhibitor_of_metalloproteinases and its identity to erythroid-potentiating_activity .
8195185	0	erythroid_Kruppel-like_factor	18,47	EKLF	49,53	erythroid Kruppel-like factor	EKLF	10661	10661	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of the erythroid_Kruppel-like_factor -LRB- EKLF -RRB- gene promoter by the erythroid transcription factor GATA-1 .
14976188	0	erythroid_Kruppel-like_factor	65,94	p40	44,47	erythroid Kruppel-like factor	p40	16596(Tax:10090)	16160(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Activation Activation|nmod|END_ENTITY	Activation and repression of interleukin-12 p40 transcription by erythroid_Kruppel-like_factor in macrophages .
8916973	0	erythroid_Krupple-like_factor	46,75	delta-globin	14,26	erythroid Krupple-like factor	delta-globin	10661	3039	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of delta-globin gene expression by erythroid_Krupple-like_factor : a potential approach for gene therapy of sickle_cell_disease .
1752318	0	erythroid_differentiation_factor	11,43	EDF	45,48	erythroid differentiation factor	EDF	3624	3624	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of erythroid_differentiation_factor -LRB- EDF -RRB- on proliferation and differentiation of human hematopoietic progenitors .
1673636	0	erythroid_differentiation_factor	14,46	P-glycoprotein	62,76	erythroid differentiation factor	P-glycoprotein	3624	5243	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition by erythroid_differentiation_factor -LRB- activin A -RRB- of P-glycoprotein expression in multidrug-resistant human K562 erythroleukemia cells .
2261953	0	erythroid_potentiating_activity	18,49	erythropoietin	73,87	erythroid potentiating activity	erythropoietin	7076	2056	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|effect effect|nmod|END_ENTITY	Recombinant human erythroid_potentiating_activity enhances the effect of erythropoietin in mice .
18694847	0	erythropoietin	81,95	AKT	32,35	erythropoietin	AKT	2056	207	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|translocation translocation|nmod|END_ENTITY	Nuclear translocation of active AKT is required for erythroid differentiation in erythropoietin treated K562 erythroleukemia cells .
23242184	0	erythropoietin	44,58	ATF4	82,86	erythropoietin	ATF4	24335(Tax:10116)	79255(Tax:10116)	Gene	Gene	production|compound|START_ENTITY production|dep|role role|nmod|END_ENTITY	Endoplasmic reticulum stress signal impairs erythropoietin production : a role for ATF4 .
15302785	0	erythropoietin	38,52	Akt	115,118	erythropoietin	Akt	2056	207	Gene	Gene	analogue|compound|START_ENTITY therapy|nmod|analogue activates|nsubj|therapy activates|dobj|END_ENTITY	Low-dose therapy with the long-acting erythropoietin analogue darbepoetin alpha persistently activates endothelial Akt and attenuates progressive organ failure .
16107690	0	erythropoietin	45,59	Akt	30,33	erythropoietin	Akt	13856(Tax:10090)	11651(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Phosphatidylinositol_3-kinase / Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation .
16918383	0	erythropoietin	38,52	Akt	76,79	erythropoietin	Akt	2056	207	Gene	Gene	maintained|nmod|START_ENTITY maintained|nmod|integration integration|nmod|END_ENTITY	Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen_synthase_kinase-3beta , beta-catenin , and nuclear factor-kappaB .
18346168	0	erythropoietin	30,44	Akt	81,84	erythropoietin	Akt	24335(Tax:10116)	24185(Tax:10116)	Gene	Gene	size|nmod|START_ENTITY Limitation|nmod|size associated|nsubjpass|Limitation associated|nmod|translocation translocation|nmod|END_ENTITY	Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion .
23337206	0	erythropoietin	51,65	Akt	89,92	erythropoietin	Akt	2056	207	Gene	Gene	effects|nmod|START_ENTITY counteracts|dobj|effects counteracts|nmod|suppression suppression|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Indoxyl_sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation .
10583422	0	erythropoietin	25,39	Angiotensin_II	0,14	erythropoietin	Angiotensin II	2056	183	Gene	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Angiotensin_II increases erythropoietin production in healthy human volunteers .
11422739	0	erythropoietin	41,55	Angiotensin_II	0,14	erythropoietin	Angiotensin II	2056	183	Gene	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nsubj|infusion infusion|compound|END_ENTITY	Angiotensin_II infusion increases plasma erythropoietin levels via an angiotensin_II_type_1_receptor-dependent pathway .
15007095	0	erythropoietin	45,59	Btk	0,3	erythropoietin	Btk	2056	695	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Btk is required for an efficient response to erythropoietin and for SCF-controlled protection against TRAIL in erythroid progenitors .
24607903	0	erythropoietin	13,27	CBP/p300	104,112	erythropoietin	CBP/p300	2056	1387;2033	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300 .
20702780	0	erythropoietin	75,89	CD4	34,37	erythropoietin	CD4	2056	920	Gene	Gene	specific|nmod|START_ENTITY specific|compound|END_ENTITY	Quantification of the preexisting CD4 T-cell repertoire specific for human erythropoietin reveals its immunogenicity potential .
21619451	0	erythropoietin	123,137	CD4	73,76	erythropoietin	CD4	2056	920	Gene	Gene	treated|nmod|START_ENTITY treated|nsubj|analysis analysis|nmod|phosphorylation phosphorylation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Flow cytometric analysis of STAT5 phosphorylation and CD95 expression in CD4 + T lymphocytes treated with recombinant human erythropoietin .
23180360	0	erythropoietin	35,49	CD4	90,93	erythropoietin	CD4	2056	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	The influence of recombinant human erythropoietin on apoptosis and cytokine production of CD4 + lymphocytes from hemodialyzed patients .
22093990	0	erythropoietin	33,47	CD59	87,91	erythropoietin	CD59	2056	966	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	-LSB- STAT5 phosphorylation levels of erythropoietin and thrombopoietin_receptors in CD34 -LRB- + -RRB- CD59 -LRB- - -RRB- and CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- bone marrow cells of patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
1294957	0	erythropoietin	13,27	D-1_to_D-29	46,57	erythropoietin	D-1 to D-29	2056	25802;55520	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	-LSB- Kinetics of erythropoietin blood levels from D-1_to_D-29 in kidney transplantation -RSB- .
11798762	0	erythropoietin	41,55	EPO	57,60	erythropoietin	EPO	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	-LSB- The effects of electroporation-mediated erythropoietin -LRB- EPO -RRB- gene transfer into skeleton muscle on renal_anemia -RSB- .
12068800	0	erythropoietin	6,20	EPO	22,25	erythropoietin	EPO	2056	2056	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum erythropoietin -LRB- EPO -RRB- levels correlate with survival and independently predict response to EPO treatment in patients with myelodysplastic_syndromes .
15672835	0	erythropoietin	24,38	EPO	40,43	erythropoietin	EPO	2056	2056	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of human erythropoietin -LRB- EPO -RRB- affects plant morphologies : retarded vegetative growth in tobacco and male sterility in tobacco and Arabidopsis .
20410932	0	erythropoietin	22,36	EPO	38,41	erythropoietin	EPO	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Therapeutic levels of erythropoietin -LRB- EPO -RRB- achieved after gene electrotransfer to skin in mice .
8139531	0	erythropoietin	20,34	EPO	36,39	erythropoietin	EPO	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A dominant negative erythropoietin -LRB- EPO -RRB- receptor inhibits EPO-dependent growth and blocks F-gp55-dependent transformation .
8634300	0	erythropoietin	48,62	EPO	64,67	erythropoietin	EPO	2056	2056	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Dimerization of the extracellular domain of the erythropoietin -LRB- EPO -RRB- receptor by EPO : one high-affinity and one low-affinity interaction .
8634300	0	erythropoietin	48,62	EPO	81,84	erythropoietin	EPO	2056	2056	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Dimerization of the extracellular domain of the erythropoietin -LRB- EPO -RRB- receptor by EPO : one high-affinity and one low-affinity interaction .
26125905	0	erythropoietin	82,96	ERK	112,115	erythropoietin	ERK	13856(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|acl|activating activating|dobj|END_ENTITY	Inhibition of adipogenic differentiation of bone marrow mesenchymal stem cells by erythropoietin via activating ERK and P38_MAPK .
8606524	0	erythropoietin	24,38	Endothelin-1	0,12	erythropoietin	Endothelin-1	2056	1906	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Endothelin-1 release by erythropoietin involves calcium signaling in endothelial cells .
7528577	0	erythropoietin	47,61	Epo	63,66	erythropoietin	Epo	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Hematopoietic_cell_phosphatase associates with erythropoietin -LRB- Epo -RRB- receptor after Epo-induced receptor tyrosine phosphorylation : identification of potential binding sites .
15456912	0	erythropoietin	53,67	Erythropoietin	0,14	erythropoietin	Erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Erythropoietin mediates tissue protection through an erythropoietin and common beta-subunit heteroreceptor .
18218911	0	erythropoietin	122,136	Erythropoietin	0,14	erythropoietin	Erythropoietin	2056	2056	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle .
25266611	0	erythropoietin	33,47	Erythropoietin	0,14	erythropoietin	Erythropoietin	2056	2056	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Erythropoietin : emerging role of erythropoietin in neonatal neuroprotection .
7084423	0	erythropoietin	80,94	Erythropoietin	0,14	erythropoietin	Erythropoietin	13856(Tax:10090)	13856(Tax:10090)	Gene	Gene	formation|nmod|START_ENTITY formation|compound|END_ENTITY	Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection .
8068943	0	erythropoietin	80,94	Erythropoietin	0,14	erythropoietin	Erythropoietin	2056	2056	Gene	Gene	receptor|compound|START_ENTITY induces|nmod|receptor induces|nsubj|END_ENTITY	Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo .
7514046	0	erythropoietin	22,36	G-CSF	80,85	erythropoietin	G-CSF	2056	1440	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A randomized study of erythropoietin and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- versus placebo and G-CSF for patients with Hodgkin 's _ and_non-Hodgkin 's _ lymphoma undergoing autologous bone marrow transplantation .
7524905	0	erythropoietin	50,64	G-CSF	88,93	erythropoietin	G-CSF	2056	1440	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	In vitro and in vivo effects of recombinant human erythropoietin plus recombinant human G-CSF on human haemopoietic progenitor cells .
12041667	0	erythropoietin	16,30	GATA	0,4	erythropoietin	GATA	13856(Tax:10090)	76563(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter .
12041667	0	erythropoietin	74,88	GATA	55,59	erythropoietin	GATA	13856(Tax:10090)	76563(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY site|nmod|promoter site|compound|END_ENTITY	GATA suppresses erythropoietin gene expression through GATA site in mouse erythropoietin gene promoter .
1660143	0	erythropoietin	18,32	GATA-1	75,81	erythropoietin	GATA-1	2056	2623	Gene	Gene	promoter|compound|START_ENTITY Activation|nmod|promoter Activation|nmod|END_ENTITY	Activation of the erythropoietin receptor promoter by transcription factor GATA-1 .
11169463	0	erythropoietin	89,103	GATA-2	15,21	erythropoietin	GATA-2	2056	2624	Gene	Gene	expression|compound|START_ENTITY Stimulation|nmod|expression Stimulation|nmod|END_ENTITY	Stimulation of GATA-2 as a mechanism of hydrogen_peroxide suppression in hypoxia-induced erythropoietin gene expression .
15595630	0	erythropoietin	49,63	GSTs	80,84	erythropoietin	GSTs	2056	373156	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|END_ENTITY	Treatment of MDS patients with recombinant human erythropoietin and the role of GSTs .
10455108	0	erythropoietin	31,45	Gab1	14,18	erythropoietin	Gab1	2056	2549	Gene	Gene	signaling|compound|START_ENTITY Engagement|nmod|signaling Engagement|nmod|END_ENTITY	Engagement of Gab1 and Gab2 in erythropoietin signaling .
19665053	0	erythropoietin	30,44	Gab1	0,4	erythropoietin	Gab1	2056	2549	Gene	Gene	signals|compound|START_ENTITY transduces|dobj|signals transduces|nsubj|END_ENTITY	Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells .
1361819	0	erythropoietin	111,125	Growth_hormone	0,14	erythropoietin	Growth hormone	2056	2688	Gene	Gene	treated|nmod|START_ENTITY treated|nsubj|responses responses|amod|END_ENTITY	Growth_hormone responses to pituitary and hypothalamic stimuli in CAPD patients treated with recombinant human erythropoietin .
7999845	0	erythropoietin	55,69	Growth_hormone	0,14	erythropoietin	Growth hormone	2056	2688	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Growth_hormone and cortisol secretion before and after erythropoietin therapy in CAPD patients .
20404921	0	erythropoietin	86,100	HIF-1alpha	49,59	erythropoietin	HIF-1alpha	13856(Tax:10090)	15251(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity .
15240563	0	erythropoietin	133,147	HIF-2alpha	153,163	erythropoietin	HIF-2alpha	2056	2034	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	Differentiating the functional role of hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 alpha and HIF-2alpha -LRB- EPAS-1 -RRB- by the use of RNA interference : erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells .
3923475	0	erythropoietin	93,107	Interleukin_3	0,13	erythropoietin	Interleukin 3	13856(Tax:10090)	16187(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Interleukin_3 promotes erythroid burst formation in `` serum-free '' cultures without detectable erythropoietin .
16465216	0	erythropoietin	50,64	JAK2	81,85	erythropoietin	JAK2	2056	3717	Gene	Gene	erythroid|nmod|START_ENTITY erythroid|parataxis|kinases kinases|nsubj|involvement involvement|nmod|END_ENTITY	Prevention of apoptosis in J2E erythroid cells by erythropoietin : involvement of JAK2 but not MAP kinases .
16827884	0	erythropoietin	15,29	JAK2	145,149	erythropoietin	JAK2	2056	3717	Gene	Gene	levels|compound|START_ENTITY levels|dep|implications implications|nmod|role role|nmod|analysis analysis|compound|END_ENTITY	Elevated serum erythropoietin levels in patients with Budd-Chiari_syndrome secondary to polycythemia vera : clinical implications for the role of JAK2 mutation analysis .
17389763	0	erythropoietin	34,48	JAK2	4,8	erythropoietin	JAK2	2056	3717	Gene	Gene	hypersensitivity|compound|START_ENTITY triggers|dobj|hypersensitivity triggers|nsubj|mutation mutation|compound|END_ENTITY	The JAK2 617V > F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia_vera .
17719087	0	erythropoietin	80,94	JAK2	115,119	erythropoietin	JAK2	2056	3717	Gene	Gene	show|nmod|START_ENTITY show|nmod|V617F-positive V617F-positive|compound|END_ENTITY	Most pediatric patients with essential_thrombocythemia show hypersensitivity to erythropoietin in vitro , with rare JAK2 V617F-positive erythroid colonies .
18055983	0	erythropoietin	93,107	JAK2	17,21	erythropoietin	JAK2	2056	3717	Gene	Gene	levels|compound|START_ENTITY exon|nmod|levels exon|nsubj|frequency frequency|nmod|END_ENTITY	The frequency of JAK2 exon 12 mutations in idiopathic_erythrocytosis patients with low serum erythropoietin levels .
7889566	0	erythropoietin	39,53	JAK2	86,90	erythropoietin	JAK2	2056	3717	Gene	Gene	receptor|compound|START_ENTITY SH-PTP1|nmod|receptor recruitment|nmod|SH-PTP1 causes|nsubj|recruitment causes|dobj|inactivation inactivation|nmod|END_ENTITY	Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals .
8068943	0	erythropoietin	80,94	JAK2	42,46	erythropoietin	JAK2	2056	3717	Gene	Gene	receptor|compound|START_ENTITY induces|nmod|receptor induces|dobj|association association|nmod|kinase kinase|compound|END_ENTITY	Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo .
8343951	0	erythropoietin	25,39	JAK2	0,4	erythropoietin	JAK2	2056	3717	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin .
8943308	0	erythropoietin	35,49	JAK2	15,19	erythropoietin	JAK2	2056	3717	Gene	Gene	receptors|compound|START_ENTITY Association|nmod|receptors Association|nmod|END_ENTITY	Association of JAK2 and STAT5 with erythropoietin receptors .
9052992	0	erythropoietin	18,32	JAK2	61,65	erythropoietin	JAK2	2056	3717	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Regulation of the erythropoietin receptor and involvement of JAK2 in differentiation of J2E erythroid cells .
10910907	0	erythropoietin	29,43	JNK	0,3	erythropoietin	JNK	2056	5599	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	JNK and p38 are activated by erythropoietin -LRB- EPO -RRB- but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells .
8034573	0	erythropoietin	32,46	Jak2	76,80	erythropoietin	Jak2	13856(Tax:10090)	16452(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY subdomain|nmod|receptor nonessential|nsubj|subdomain nonessential|nmod|activation activation|amod|END_ENTITY	The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells .
25829192	0	erythropoietin	91,105	L11	18,21	erythropoietin	L11	2056	6135	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Ribosomal protein L11 and retinol_dehydrogenase_11 induced erythroid_proliferation without erythropoietin in UT-7 / Epo erythroleukemic cells .
12804176	0	erythropoietin	47,61	Macrophage-stimulating_protein	0,30	erythropoietin	Macrophage-stimulating protein	13856(Tax:10090)	15235(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Macrophage-stimulating_protein cooperates with erythropoietin to induce colony_formation_and_MAP kinase activation in primary erythroid progenitor cells .
11495725	0	erythropoietin	56,70	NF-kappaB	39,48	erythropoietin	NF-kappaB	2056	4790	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Activation of the transcription factor NF-kappaB by the erythropoietin receptor : structural requirements and biological significance .
12482504	0	erythropoietin	67,81	NF-kappaB	0,9	erythropoietin	NF-kappaB	2056	4790	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression plays|dobj|role plays|nsubj|END_ENTITY	NF-kappaB plays a key role in hypoxia-inducible_factor-1-regulated erythropoietin gene expression .
25008877	0	erythropoietin	12,26	NSE	36,39	erythropoietin	NSE	2056	2026	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of erythropoietin on serum NSE and S-100B levels in neonates with hypoxic-ischemic_encephalopathy -RSB- .
9454748	0	erythropoietin	38,52	P19	20,23	erythropoietin	P19	13856(Tax:10090)	83430(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	Embryonal_carcinoma P19 cells produce erythropoietin constitutively but express lactate dehydrogenase in an oxygen-dependent manner .
11124936	0	erythropoietin	21,35	Rap1	0,4	erythropoietin	Rap1	2056	5906	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1_integrin-mediated hematopoietic cell adhesion .
20505289	0	erythropoietin	28,42	S100B	52,57	erythropoietin	S100B	2056	6285	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of recombinant human erythropoietin on serum S100B protein and interleukin-6 levels after traumatic_brain_injury in the rat .
7889566	0	erythropoietin	39,53	SH-PTP1	24,31	erythropoietin	SH-PTP1	2056	5777	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals .
22230249	0	erythropoietin	89,103	STAT3	14,19	erythropoietin	STAT3	24335(Tax:10116)	25125(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibits|nmod|expression inhibits|nsubj|activation activation|compound|END_ENTITY	VEGF-mediated STAT3 activation inhibits retinal vascularization by down-regulating local erythropoietin expression .
10339482	0	erythropoietin	84,98	STAT5	61,66	erythropoietin	STAT5	2056	6776	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Protein_kinase_B _ -LRB- c-Akt -RRB- , phosphatidylinositol 3-kinase , and STAT5 are activated by erythropoietin -LRB- EPO -RRB- in HCD57 erythroid cells but are constitutively active in an EPO-independent , apoptosis-resistant subclone -LRB- HCD57-SREI cells -RRB- .
11696536	0	erythropoietin	114,128	STAT5	83,88	erythropoietin	STAT5	13856(Tax:10090)	20850(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Regulation of Socs gene expression by the proto-oncoprotein GFI-1B : two routes for STAT5 target gene induction by erythropoietin .
16407271	0	erythropoietin	25,39	STAT5	117,122	erythropoietin	STAT5	2056	6776	Gene	Gene	effects|nmod|START_ENTITY require|nsubj|effects require|dobj|activation activation|nmod|END_ENTITY	Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways .
21619451	0	erythropoietin	123,137	STAT5	28,33	erythropoietin	STAT5	2056	6776	Gene	Gene	treated|nmod|START_ENTITY treated|nsubj|analysis analysis|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Flow cytometric analysis of STAT5 phosphorylation and CD95 expression in CD4 + T lymphocytes treated with recombinant human erythropoietin .
22093990	0	erythropoietin	33,47	STAT5	1,6	erythropoietin	STAT5	2056	6776	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	-LSB- STAT5 phosphorylation levels of erythropoietin and thrombopoietin_receptors in CD34 -LRB- + -RRB- CD59 -LRB- - -RRB- and CD34 -LRB- + -RRB- CD59 -LRB- + -RRB- bone marrow cells of patients with paroxysmal_nocturnal_hemoglobinuria -RSB- .
8665851	0	erythropoietin	75,89	STAT5	111,116	erythropoietin	STAT5	13856(Tax:10090)	20850(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY domain|nmod|receptor residues|nmod|domain Identification|nmod|residues Identification|amod|crucial crucial|nmod|activation activation|compound|END_ENTITY	Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation .
9079629	0	erythropoietin	33,47	STAT5	0,5	erythropoietin	STAT5	2056	6776	Gene	Gene	differentiation|compound|START_ENTITY correlates|nmod|differentiation correlates|nsubj|activation activation|compound|END_ENTITY	STAT5 activation correlates with erythropoietin receptor-mediated erythroid differentiation of an erythroleukemia cell line .
15062567	0	erythropoietin	10,24	Stat5	77,82	erythropoietin	Stat5	24335(Tax:10116)	24918(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY associated|nsubjpass|Effect associated|nmod|activation activation|nmod|pathway pathway|amod|END_ENTITY	Effect of erythropoietin on Leydig cell is associated with the activation of Stat5 pathway .
8977232	0	erythropoietin	97,111	Stat5	45,50	erythropoietin	Stat5	2056	6776	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3 .
8626614	0	erythropoietin	25,39	TR2	63,66	erythropoietin	TR2	2056	7181	Gene	Gene	expression|compound|START_ENTITY expression|nmod|receptor receptor|compound|END_ENTITY	Suppression of the human erythropoietin gene expression by the TR2 orphan receptor , a member of the steroid receptor superfamily .
14699131	0	erythropoietin	34,48	TRPC2	15,20	erythropoietin	TRPC2	13856(Tax:10090)	22064(Tax:10090)	Gene	Gene	modulation|compound|START_ENTITY Interaction|nmod|modulation Interaction|nmod|END_ENTITY	Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx .
21757714	0	erythropoietin	147,161	TRPC3	127,132	erythropoietin	TRPC3	2056	7222	Gene	Gene	required|nmod|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	The transient receptor potential -LRB- TRP -RRB- channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin .
7535585	0	erythropoietin	56,70	Thrombopoietin	0,14	erythropoietin	Thrombopoietin	13856(Tax:10090)	21832(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Thrombopoietin -LRB- c-mpl_ligand -RRB- acts synergistically with erythropoietin , stem_cell_factor , and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro .
15705187	0	erythropoietin	90,104	Vascular_endothelial_growth_factor	0,34	erythropoietin	Vascular endothelial growth factor	2056	7422	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor and its soluble receptor , Flt-1 , are not correlated to erythropoietin in diabetics with normal or reduced renal function .
16796823	0	erythropoietin	49,63	Vascular_endothelial_growth_factor	0,34	erythropoietin	Vascular endothelial growth factor	2056	7422	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces brain erythropoietin expression ?
10784360	0	erythropoietin	49,63	angiotensin_II	25,39	erythropoietin	angiotensin II	2056	183	Gene	Gene	production|compound|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Dose-dependent effect of angiotensin_II on human erythropoietin production .
12968982	0	erythropoietin	60,74	angiotensin_II	29,43	erythropoietin	angiotensin II	2056	183	Gene	Gene	production|compound|START_ENTITY regulate|dobj|production regulate|nsubj|alterations alterations|nmod|levels levels|compound|END_ENTITY	Do alterations of endogenous angiotensin_II levels regulate erythropoietin production in humans ?
15627795	0	erythropoietin	29,43	angiotensin_II	5,19	erythropoietin	angiotensin II	2056	183	Gene	Gene	production|compound|START_ENTITY modulate|dobj|production modulate|nsubj|END_ENTITY	Does angiotensin_II modulate erythropoietin production in HepG2 cells ?
24695083	0	erythropoietin	13,27	angiotensin_II	42,56	erythropoietin	angiotensin II	2056	183	Gene	Gene	regulation|compound|START_ENTITY Mechanism|nmod|regulation Mechanism|nmod|END_ENTITY	Mechanism of erythropoietin regulation by angiotensin_II .
19080694	0	erythropoietin	12,26	aquaporin-2	48,59	erythropoietin	aquaporin-2	24335(Tax:10116)	25386(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of erythropoietin on the expression of aquaporin-2 after renal_ischemia-reperfusion injury : experiment with rats -RSB- .
15686664	0	erythropoietin	10,24	bcl-2	28,33	erythropoietin	bcl-2	24335(Tax:10116)	24224(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of erythropoietin on bcl-2 gene expression in rat cardiac myocytes after traumatic_brain_injury .
20335137	0	erythropoietin	29,43	bcl-2	47,52	erythropoietin	bcl-2	2056	596	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of recombinant human erythropoietin on bcl-2 protein expression in the retina in a rabbit model of acute high intraocular pressure -RSB- .
20132233	0	erythropoietin	142,156	caspase_3	118,127	erythropoietin	caspase 3	2056	836	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	Erythropoietin inhibits gamma-irradiation-induced apoptosis by upregulation of Bcl-2 and decreasing the activation of caspase_3 in human UT-7 / erythropoietin cell line .
11482502	0	erythropoietin	31,45	endothelin-1	64,76	erythropoietin	endothelin-1	2056	1906	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|levels levels|amod|END_ENTITY	Influence of recombinant human erythropoietin therapy on plasma endothelin-1 levels during hemodialysis .
21777087	0	erythropoietin	18,32	endothelin-1	147,159	erythropoietin	endothelin-1	24335(Tax:10116)	24323(Tax:10116)	Gene	Gene	alters|nsubj|START_ENTITY alters|nmod|ratio ratio|amod|END_ENTITY	Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric_oxide ratio .
8502330	0	erythropoietin	25,39	endothelin-1	61,73	erythropoietin	endothelin-1	2056	1906	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|nmod|artery artery|amod|END_ENTITY	Influence of recombinant erythropoietin on the production of endothelin-1 from human umbilical artery .
8510379	0	erythropoietin	18,32	endothelin-1	52,64	erythropoietin	endothelin-1	2056	1906	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|release release|amod|END_ENTITY	Recombinant human erythropoietin -LRB- rHuEPO -RRB- increases endothelin-1 release by endothelial cells .
8788598	0	erythropoietin	18,32	endothelin-1	69,81	erythropoietin	endothelin-1	2056	1906	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|expression expression|nmod|synthase synthase|amod|END_ENTITY	Recombinant human erythropoietin does not regulate the expression of endothelin-1 and constitutive nitric_oxide synthase in vascular endothelial cells .
8887285	0	erythropoietin	18,32	endothelin-1	67,79	erythropoietin	endothelin-1	2056	1906	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|tone tone|nmod|prostanoids prostanoids|amod|END_ENTITY	Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids .
9056686	0	erythropoietin	11,25	endothelin-1	29,41	erythropoietin	endothelin-1	2056	1906	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|amod|END_ENTITY	Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells .
9817611	0	erythropoietin	93,107	endothelin-1	24,36	erythropoietin	endothelin-1	24335(Tax:10116)	24323(Tax:10116)	Gene	Gene	treated|nmod|START_ENTITY rats|acl|treated vessel|nmod|rats vessel|dobj|concentrations concentrations|amod|END_ENTITY	Plasma and blood vessel endothelin-1 concentrations in hypertensive uremic rats treated with erythropoietin .
2261953	0	erythropoietin	73,87	erythroid_potentiating_activity	18,49	erythropoietin	erythroid potentiating activity	2056	7076	Gene	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nsubj|END_ENTITY	Recombinant human erythroid_potentiating_activity enhances the effect of erythropoietin in mice .
11739166	0	erythropoietin	40,54	erythropoietin	86,100	erythropoietin	erythropoietin	2056	2056	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin .
11739166	0	erythropoietin	86,100	erythropoietin	40,54	erythropoietin	erythropoietin	2056	2056	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Sugar profiling proves that human serum erythropoietin differs from recombinant human erythropoietin .
12446199	0	erythropoietin	105,119	erythropoietin	12,26	erythropoietin	erythropoietin	2056	2056	Gene	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response to erythropoietin and moxifloxacin in a patient with myelodysplastic_syndrome non-respondent to erythropoietin alone .
12446199	0	erythropoietin	12,26	erythropoietin	105,119	erythropoietin	erythropoietin	2056	2056	Gene	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response to erythropoietin and moxifloxacin in a patient with myelodysplastic_syndrome non-respondent to erythropoietin alone .
1421034	0	erythropoietin	6,20	erythropoietin	95,109	erythropoietin	erythropoietin	2056	2056	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Serum erythropoietin levels in hemodialysed patients after administration of recombinant human erythropoietin .
1421034	0	erythropoietin	95,109	erythropoietin	6,20	erythropoietin	erythropoietin	2056	2056	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum erythropoietin levels in hemodialysed patients after administration of recombinant human erythropoietin .
22100268	0	erythropoietin	16,30	erythropoietin	82,96	erythropoietin	erythropoietin	2056	2056	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Optimization of erythropoietin production with controlled glycosylation-PEGylated erythropoietin produced in glycoengineered Pichia_pastoris .
22100268	0	erythropoietin	82,96	erythropoietin	16,30	erythropoietin	erythropoietin	2056	2056	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Optimization of erythropoietin production with controlled glycosylation-PEGylated erythropoietin produced in glycoengineered Pichia_pastoris .
2341370	0	erythropoietin	63,77	erythropoietin	97,111	erythropoietin	erythropoietin	2056	2056	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	Physicochemical and biological comparison of recombinant human erythropoietin with human urinary erythropoietin .
2341370	0	erythropoietin	97,111	erythropoietin	63,77	erythropoietin	erythropoietin	2056	2056	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	Physicochemical and biological comparison of recombinant human erythropoietin with human urinary erythropoietin .
3574798	0	erythropoietin	15,29	erythropoietin	63,77	erythropoietin	erythropoietin	2056	2056	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Amniotic fluid erythropoietin correlates with umbilical plasma erythropoietin in normal and abnormal pregnancy .
3574798	0	erythropoietin	63,77	erythropoietin	15,29	erythropoietin	erythropoietin	2056	2056	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Amniotic fluid erythropoietin correlates with umbilical plasma erythropoietin in normal and abnormal pregnancy .
8737755	0	erythropoietin	111,125	erythropoietin	38,52	erythropoietin	erythropoietin	2056	2056	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Comparison of dose requirement , serum erythropoietin and blood pressure following intravenous and subcutaneous erythropoietin treatment of dialysis patients .
8737755	0	erythropoietin	38,52	erythropoietin	111,125	erythropoietin	erythropoietin	2056	2056	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Comparison of dose requirement , serum erythropoietin and blood pressure following intravenous and subcutaneous erythropoietin treatment of dialysis patients .
9458299	0	erythropoietin	107,121	erythropoietin	6,20	erythropoietin	erythropoietin	2056	2056	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Serum erythropoietin and creatinine concentrations as predictive factors for response to recombinant human erythropoietin treatment in anaemic tumour patients on chemotherapy .
9458299	0	erythropoietin	6,20	erythropoietin	107,121	erythropoietin	erythropoietin	2056	2056	Gene	Gene	START_ENTITY|nmod|treatment treatment|compound|END_ENTITY	Serum erythropoietin and creatinine concentrations as predictive factors for response to recombinant human erythropoietin treatment in anaemic tumour patients on chemotherapy .
9079694	0	erythropoietin	35,49	erythropoietin_mRNA-binding_protein	68,103	erythropoietin	erythropoietin mRNA-binding protein	2056	30836	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability regulation|nmod|END_ENTITY	Post-transcriptional regulation of erythropoietin mRNA stability by erythropoietin_mRNA-binding_protein .
17912447	0	erythropoietin	85,99	erythropoietin_receptor	45,68	erythropoietin	erythropoietin receptor	2056	2057	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Glioblastoma multiforme cells : expression of erythropoietin_receptor and response to erythropoietin .
18581197	0	erythropoietin	18,32	frataxin	43,51	erythropoietin	frataxin	2056	2395	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Recombinant human erythropoietin increases frataxin protein expression without increasing mRNA expression .
21597884	0	erythropoietin	11,25	frataxin	29,37	erythropoietin	frataxin	2056	2395	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Effects of erythropoietin on frataxin levels and mitochondrial function in Friedreich_ataxia -- a dose-response trial .
7854499	0	erythropoietin	9,23	gamma-glutamyl_transpeptidase	43,72	erythropoietin	gamma-glutamyl transpeptidase	13856(Tax:10090)	14598(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Enhanced erythropoietin and suppression of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- activity in murine lymphoma following administration of vanadium .
24524370	0	erythropoietin	27,41	ghrelin	10,17	erythropoietin	ghrelin	24335(Tax:10116)	59301(Tax:10116)	Gene	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of ghrelin on renal erythropoietin production in chronic hypoxic rats .
21269949	0	erythropoietin	11,25	granulocyte-colony_stimulating_factor	40,77	erythropoietin	granulocyte-colony stimulating factor	24335(Tax:10116)	25610(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY combined|nsubj|Effect combined|nmod|END_ENTITY	-LSB- Effect of erythropoietin combined with granulocyte-colony_stimulating_factor in the treatment of acute myocardial_infarction in rats -RSB- .
10089903	0	erythropoietin	164,178	granulocyte_colony-stimulating_factor	13,50	erythropoietin	granulocyte colony-stimulating factor	2056	1440	Gene	Gene	START_ENTITY|nsubj|Expansion Expansion|nmod|END_ENTITY	Expansion of granulocyte_colony-stimulating_factor / chemotherapy-mobilized CD34 + hematopoietic progenitors : role of granulocyte-macrophage_colony-stimulating_factor / erythropoietin hybrid protein -LRB- MEN11303 -RRB- and interleukin-15 .
7687889	0	erythropoietin	135,149	granulocyte_colony-stimulating_factor	77,114	erythropoietin	granulocyte colony-stimulating factor	2056	1440	Gene	Gene	using|nmod|START_ENTITY using|dobj|END_ENTITY	Treatment of the anemia of myelodysplastic syndromes using recombinant human granulocyte_colony-stimulating_factor in combination with erythropoietin .
9186538	0	erythropoietin	75,89	granulocyte_colony-stimulating_factor	110,147	erythropoietin	granulocyte colony-stimulating factor	2056	1440	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Treatment of the anemia of aplastic_anemia patients with recombinant human erythropoietin in combination with granulocyte_colony-stimulating_factor : a multicenter randomized controlled study .
26788441	0	erythropoietin	72,86	growth_arrest-specific_protein_6	12,44	erythropoietin	growth arrest-specific protein 6	2056	2621	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|levels levels|amod|END_ENTITY	Circulating growth_arrest-specific_protein_6 levels are associated with erythropoietin resistance in hemodialysis patients .
10024084	0	erythropoietin	39,53	growth_hormone	65,79	erythropoietin	growth hormone	2056	2688	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|secretion secretion|amod|END_ENTITY	Long-term effects of recombinant human erythropoietin therapy on growth_hormone secretion in uremic patients undergoing peritoneal dialysis .
10698049	0	erythropoietin	71,85	growth_hormone	53,67	erythropoietin	growth hormone	2056	2688	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effect of long-term treatment with recombinant human growth_hormone on erythropoietin secretion in an anemic patient with panhypopituitarism .
10913939	0	erythropoietin	29,43	growth_hormone	72,86	erythropoietin	growth hormone	2056	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of acute infusion of erythropoietin on paradoxical responses of growth_hormone to thyrotropin-releasing_hormone in acromegalic patients .
11895216	0	erythropoietin	88,102	growth_hormone	56,70	erythropoietin	growth hormone	2056	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|administration administration|nmod|END_ENTITY	Effect of long-term administration of recombinant human growth_hormone -LRB- rhGH -RRB- on plasma erythropoietin -LRB- EPO -RRB- and haemoglobin levels in anaemic patients with adult_GH_deficiency .
19960893	0	erythropoietin	76,90	growth_hormone	28,42	erythropoietin	growth hormone	2056	2688	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels therapy|acl|circulating therapy|compound|END_ENTITY	Effect of human recombinant growth_hormone therapy on circulating levels of erythropoietin and granulocyte-colony_stimulating_factor in short children .
2004477	0	erythropoietin	81,95	growth_hormone	10,24	erythropoietin	growth hormone	2056	2688	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|response response|amod|END_ENTITY	Increased growth_hormone response to growth_hormone_releasing_hormone induced by erythropoietin in uraemic patients .
7853798	0	erythropoietin	13,27	growth_hormone	56,70	erythropoietin	growth hormone	2056	2688	Gene	Gene	START_ENTITY|nmod|responses responses|nmod|END_ENTITY	Influence of erythropoietin on paradoxical responses of growth_hormone to thyrotropin-releasing_hormone in uremic patients .
8513607	0	erythropoietin	18,32	growth_hormone	63,77	erythropoietin	growth hormone	2056	2688	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|response response|amod|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
19106487	0	erythropoietin	50,64	hEPO	66,70	erythropoietin	hEPO	2056	2056	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Production of transgenic pigs harboring the human erythropoietin -LRB- hEPO -RRB- gene using somatic cell nuclear transfer .
10233887	0	erythropoietin	51,65	hematopoietic_progenitor_kinase-1	14,47	erythropoietin	hematopoietic progenitor kinase-1	2056	11184	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of hematopoietic_progenitor_kinase-1 by erythropoietin .
16554668	0	erythropoietin	76,90	heme_oxygenase-1	11,27	erythropoietin	heme oxygenase-1	2056	3162	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	A role for heme_oxygenase-1 in the antioxidant and antiapoptotic effects of erythropoietin : the start of a good news/bad news story ?
18996987	0	erythropoietin	60,74	heme_oxygenase-1	8,24	erythropoietin	heme oxygenase-1	13856(Tax:10090)	15368(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|amod|END_ENTITY	Role of heme_oxygenase-1 in the cardioprotective effects of erythropoietin during myocardial_ischemia and reperfusion .
10942406	0	erythropoietin	16,30	hypoxia-inducible_factor-1_alpha	46,78	erythropoietin	hypoxia-inducible factor-1 alpha	2056	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Epolones induce erythropoietin expression via hypoxia-inducible_factor-1_alpha activation .
21309574	0	erythropoietin	57,71	hypoxia-inducible_factor-1a	136,163	erythropoietin	hypoxia-inducible factor-1a	2056	3091	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|parataxis|mediated mediated|nmod|accumulation accumulation|nmod|END_ENTITY	Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells : a signaling mediated via the accumulation of hypoxia-inducible_factor-1a .
25184890	0	erythropoietin	68,82	hypoxia-inducible_factor-1a	87,114	erythropoietin	hypoxia-inducible factor-1a	2056	3091	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	The extract of Ziziphus jujuba fruit -LRB- jujube -RRB- induces expression of erythropoietin via hypoxia-inducible_factor-1a in cultured Hep3B cells .
10385249	0	erythropoietin	18,32	iNOS	42,46	erythropoietin	iNOS	2056	4843	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	Recombinant human erythropoietin inhibits iNOS activity and reverts vascular_dysfunction in splanchnic_artery_occlusion shock .
19552740	0	erythropoietin	28,42	insulin	46,53	erythropoietin	insulin	2056	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	Effect of recombinant human erythropoietin on insulin resistance in hemodialysis patients .
7545423	0	erythropoietin	75,89	interleukin-11	19,33	erythropoietin	interleukin-11	13856(Tax:10090)	16156(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	In vivo effects of interleukin-11 and stem_cell_factor in combination with erythropoietin in the regulation of erythropoiesis .
10491027	0	erythropoietin	18,32	interleukin_2	58,71	erythropoietin	interleukin 2	2056	3558	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Recombinant human erythropoietin stimulates production of interleukin_2 by whole blood cell cultures of hemodialysis patients .
15988318	0	erythropoietin	73,87	interleukin_3	89,102	erythropoietin	interleukin 3	2056	3562	Gene	Gene	interleukin_6|compound|START_ENTITY interleukin_6|dep|END_ENTITY	Association between nucleated red blood cells in blood and the levels of erythropoietin , interleukin_3 , interleukin_6 , and interleukin 12p70 .
1722396	0	erythropoietin	14,28	interleukin_3	68,81	erythropoietin	interleukin 3	2056	3562	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Growth signal erythropoietin activates the same tyrosine kinases as interleukin_3 , but activates only one tyrosine kinase as differentiation signal .
2844574	0	erythropoietin	47,61	interleukin_3	89,102	erythropoietin	interleukin 3	13856(Tax:10090)	16187(Tax:10090)	Gene	Gene	receptors|nmod|START_ENTITY Down-modulation|nmod|receptors erythroblasts|nsubj|Down-modulation erythroblasts|nmod|END_ENTITY	Down-modulation of high-affinity receptors for erythropoietin on murine erythroblasts by interleukin_3 .
7528591	0	erythropoietin	14,28	interleukin_3	30,43	erythropoietin	interleukin 3	2056	3562	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|appos|END_ENTITY	Synergy among erythropoietin , interleukin_3 , stem_cell_factor -LRB- c-kit_ligand -RRB- and interferon-gamma on early human hematopoiesis .
8619836	0	erythropoietin	64,78	jun	14,17	erythropoietin	jun	2056	3725	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of jun expression and activation of AP-1 activity by erythropoietin .
16772708	0	erythropoietin	10,24	liver-type_fatty-acid-binding_protein	36,73	erythropoietin	liver-type fatty-acid-binding protein	2056	2168	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of erythropoietin on urinary liver-type_fatty-acid-binding_protein in patients with chronic_renal_failure and anemia .
23029019	0	erythropoietin	46,60	mTOR	61,65	erythropoietin	mTOR	2056	21977(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection .
23148990	0	erythropoietin	22,36	mTOR	86,90	erythropoietin	mTOR	2056	21977(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY linked|nsubjpass|functions linked|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Distinct functions of erythropoietin and stem_cell_factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors .
15635607	0	erythropoietin	51,65	neuronal_PAS_domain_protein_1	18,47	erythropoietin	neuronal PAS domain protein 1	2056	4861	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Novel function of neuronal_PAS_domain_protein_1 in erythropoietin expression in neuronal cells .
10943842	0	erythropoietin	28,42	p38alpha	16,24	erythropoietin	p38alpha	2056	1432	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Requirement for p38alpha in erythropoietin expression : a role for stress kinases in erythropoiesis .
11522867	0	erythropoietin	84,98	p80	28,31	erythropoietin	p80	2056	8161	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	High blood soluble receptor p80 for tumour necrosis factor-alpha is associated with erythropoietin resistance in haemodialysis patients .
1738400	0	erythropoietin	16,30	renin	41,46	erythropoietin	renin	2056	5972	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|compound|END_ENTITY	Acute effect of erythropoietin on plasma renin activity and aldosterone levels in end-stage_renal_disease .
989773	0	erythropoietin	30,44	renin	10,15	erythropoietin	renin	24335(Tax:10116)	24715(Tax:10116)	Gene	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of renin on extrarenal erythropoietin production .
16356735	0	erythropoietin	59,73	stem_cell_factor	31,47	erythropoietin	stem cell factor	2056	4254	Gene	Gene	peptide|compound|START_ENTITY fused|nmod|peptide fused|nsubj|expression expression|nmod|END_ENTITY	High-level expression of human stem_cell_factor fused with erythropoietin mimetic peptide in Escherichia_coli .
7528591	0	erythropoietin	14,28	stem_cell_factor	45,61	erythropoietin	stem cell factor	2056	4254	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|appos|END_ENTITY	Synergy among erythropoietin , interleukin_3 , stem_cell_factor -LRB- c-kit_ligand -RRB- and interferon-gamma on early human hematopoiesis .
9642254	0	erythropoietin	83,97	stem_cell_factor	101,117	erythropoietin	stem cell factor	2056	4254	Gene	Gene	responsiveness|nmod|START_ENTITY gene|nmod|responsiveness Induction|nmod|gene Induction|nmod|END_ENTITY	Induction of the erythropoietin_receptor gene and acquisition of responsiveness to erythropoietin by stem_cell_factor in HML/SE , a human leukemic cell line .
9816264	0	erythropoietin	127,141	stem_cell_factor	42,58	erythropoietin	stem cell factor	2056	4254	Gene	Gene	serum|nsubj|START_ENTITY serum|nmod|stimulation stimulation|nmod|erythropoiesis erythropoiesis|nmod|END_ENTITY	In vitro stimulation of erythropoiesis by stem_cell_factor alone in myelodysplastic_syndrome patients with elevated endogenous erythropoietin serum levels .
11474308	0	erythropoietin	72,86	thrombopoietin	43,57	erythropoietin	thrombopoietin	2056	7066	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of the liver in the production of thrombopoietin compared with erythropoietin .
11554233	0	erythropoietin	64,78	thrombopoietin	26,40	erythropoietin	thrombopoietin	2056	7066	Gene	Gene	erythropoiesis|nmod|START_ENTITY END_ENTITY|nmod|erythropoiesis	The synergistic effect of thrombopoietin in erythropoiesis with erythropoietin and/or IL-3 and myelopoiesis with G-CSF or IL-3 from umbilical cord blood cells of full-term neonates .
12186362	0	erythropoietin	64,78	thrombopoietin	26,40	erythropoietin	thrombopoietin	2056	7066	Gene	Gene	erythropoiesis|nmod|START_ENTITY END_ENTITY|nmod|erythropoiesis	The synergistic effect of thrombopoietin in erythropoiesis with erythropoietin and/or IL-3 and myelopoiesis with G-CSF or IL-3 from umbilical cord blood cells of premature neonates .
15879702	0	erythropoietin	64,78	thrombopoietin	15,29	erythropoietin	thrombopoietin	2056	7066	Gene	Gene	expression|nmod|START_ENTITY confers|dobj|expression confers|nsubj|Half Half|nmod|cDNA cDNA|compound|END_ENTITY	3 ' - Half of the thrombopoietin cDNA confers higher expression of erythropoietin at the RNA level but not at the protein level .
19878361	0	erythropoietin	102,116	thrombopoietin	7,21	erythropoietin	thrombopoietin	2056	7066	Gene	Gene	receiving|dobj|START_ENTITY patients|acl|receiving END_ENTITY|nmod|patients	Plasma thrombopoietin level and platelet indices in hemodialysis patients receiving recombinant human erythropoietin .
18261259	0	erythropoietin	121,135	transferrin_receptor	40,60	erythropoietin	transferrin receptor	2056	7037	Gene	Gene	given|dobj|START_ENTITY patients|acl|given reticulocytes|nmod|patients END_ENTITY|nmod|reticulocytes	A peculiar pattern of expression of the transferrin_receptor -LRB- CD71 -RRB- by reticulocytes in patients given recombinant human erythropoietin -LRB- rHuEPO -RRB- : a novel marker for abuse in sport ?
7936843	0	erythropoietin	87,101	transferrin_receptor	37,57	erythropoietin	transferrin receptor	2056	7037	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|rise rise|nmod|concentration concentration|nmod|END_ENTITY	Early rise in serum concentration of transferrin_receptor induced by recombinant human erythropoietin in very-low-birth-weight_infants .
8400253	0	erythropoietin	50,64	transferrin_receptor	119,139	erythropoietin	transferrin receptor	2056	7037	Gene	Gene	prediction|nmod|START_ENTITY prediction|nmod|END_ENTITY	Early prediction of response to recombinant human erythropoietin in patients with the anemia of renal_failure by serum transferrin_receptor and fibrinogen .
8921926	0	erythropoietin	40,54	transferrin_receptor	12,32	erythropoietin	transferrin receptor	2056	7037	Gene	Gene	medication|compound|START_ENTITY Circulating|nmod|medication Circulating|dobj|END_ENTITY	Circulating transferrin_receptor during erythropoietin medication of anemic patients with rheumatoid_arthritis .
9002972	0	erythropoietin	42,56	transferrin_receptor	116,136	erythropoietin	transferrin receptor	2056	7037	Gene	Gene	metabolism|nmod|START_ENTITY Regulation|nmod|metabolism Regulation|dep|activation activation|nmod|expression expression|compound|END_ENTITY	Regulation of cellular iron metabolism by erythropoietin : activation of iron-regulatory protein and upregulation of transferrin_receptor expression in erythroid cells .
9387133	0	erythropoietin	147,161	transketolase	58,71	erythropoietin	transketolase	2056	7086	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Comparison of the thiamine level in blood and erythrocyte transketolase activity in hemodialyzed and nondialyzed patients during recombinant human erythropoietin therapy .
17607964	0	erythropoietin	18,32	tumor_necrosis_factor-alpha	229,256	erythropoietin	tumor necrosis factor-alpha	2056	7124	Gene	Gene	influence|nmod|START_ENTITY -LSB-|dobj|influence induced|csubj|-LSB- induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
18399174	0	erythropoietin	66,80	tumor_necrosis_factor-alpha	14,41	erythropoietin	tumor necrosis factor-alpha	2056	7124	Gene	Gene	production|compound|START_ENTITY Influence|nmod|production Influence|nmod|END_ENTITY	-LSB- Influence of tumor_necrosis_factor-alpha and interferon-gamma on erythropoietin production and erythropoiesis in cancer patients with anemia -RSB- .
2303102	0	erythropoietin	106,120	tumor_necrosis_factor-alpha	41,68	erythropoietin	tumor necrosis factor-alpha	13856(Tax:10090)	21926(Tax:10090)	Gene	Gene	reversal|nmod|START_ENTITY reversal|nmod|suppression suppression|nmod|erythropoiesis erythropoiesis|nmod|END_ENTITY	In vivo suppression of erythropoiesis by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- : reversal with exogenous erythropoietin -LRB- EPO -RRB- .
14990112	0	erythropoietin	184,198	tumor_necrosis_factor_alpha	153,180	erythropoietin	tumor necrosis factor alpha	2056	7124	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Relationship between tumor_necrosis_factor_alpha , interleukin-6 and erythropoietin in children 's with chronic anemia and influence of recombinant human tumor_necrosis_factor_alpha on erythropoietin gene expression -RSB- .
10408258	0	erythropoietin	18,32	vascular_endothelial_growth_factor	44,78	erythropoietin	vascular endothelial growth factor	2056	7422	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Recombinant human erythropoietin stimulates vascular_endothelial_growth_factor release by glomerular endothelial cells .
11045267	0	erythropoietin	67,81	vascular_endothelial_growth_factor	15,49	erythropoietin	vascular endothelial growth factor	2056	7422	Gene	Gene	treatment|compound|START_ENTITY influenced|nmod|treatment influenced|nsubjpass|level level|nmod|END_ENTITY	Serum level of vascular_endothelial_growth_factor is influenced by erythropoietin treatment in peritoneal_dialysis patients .
21365780	0	erythropoietin	72,86	vascular_endothelial_growth_factor	9,43	erythropoietin	vascular endothelial growth factor	2056	7422	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|END_ENTITY	Elevated vascular_endothelial_growth_factor is correlated with elevated erythropoietin in stable , young cystic_fibrosis patients .
21819507	0	erythropoietin	150,164	vascular_endothelial_growth_factor	25,59	erythropoietin	vascular endothelial growth factor	2056	7422	Gene	Gene	injection|compound|START_ENTITY humour|nmod|injection humour|dobj|levels levels|nmod|END_ENTITY	Aqueous humour levels of vascular_endothelial_growth_factor and erythropoietin in patients with diabetic_macular_oedema before and after intravitreal erythropoietin injection .
27081865	0	erythropoietin	10,24	vascular_endothelial_growth_factor	47,81	erythropoietin	vascular endothelial growth factor	2056	7422	Gene	Gene	Effect|nmod|START_ENTITY stimulating|nsubj|Effect stimulating|dobj|agents agents|nmod|levels levels|compound|END_ENTITY	Effect of erythropoietin stimulating agents on vascular_endothelial_growth_factor levels in patients with end_stage_renal_disease .
9079694	0	erythropoietin_mRNA-binding_protein	68,103	erythropoietin	35,49	erythropoietin mRNA-binding protein	erythropoietin	30836	2056	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|stability stability|compound|END_ENTITY	Post-transcriptional regulation of erythropoietin mRNA stability by erythropoietin_mRNA-binding_protein .
18495932	0	erythropoietin_receptor	28,51	EPO-R	53,58	erythropoietin receptor	EPO-R	2057	2057	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Synergistic upregulation of erythropoietin_receptor -LRB- EPO-R -RRB- expression by sense and antisense EPO-R transcripts in the canine lung .
1962754	0	erythropoietin_receptor	18,41	EPOR	43,47	erythropoietin receptor	EPOR	13857(Tax:10090)	13857(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the erythropoietin_receptor -LRB- EPOR -RRB- gene to mouse chromosome 9 and human chromosome 19 .
21255641	0	erythropoietin_receptor	46,69	JAK2	141,145	erythropoietin receptor	JAK2	13857(Tax:10090)	16452(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY activation|nmod|phosphorylation Akt|acl|activation required|nsubjpass|Akt required|nmod|transformation transformation|compound|END_ENTITY	Akt activation through the phosphorylation of erythropoietin_receptor at tyrosine 479 is required for myeloproliferative disorder-associated JAK2 V617F mutant-induced cellular transformation .
16982687	0	erythropoietin_receptor	19,42	Jak2	62,66	erythropoietin receptor	Jak2	2057	3717	Gene	Gene	domains|nmod|START_ENTITY sufficient|nsubj|domains sufficient|nmod|binding/activation binding/activation|amod|END_ENTITY	Two domains of the erythropoietin_receptor are sufficient for Jak2 binding/activation and function .
18160720	0	erythropoietin_receptor	38,61	Jak2	0,4	erythropoietin receptor	Jak2	2057	3717	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Jak2 FERM domain interaction with the erythropoietin_receptor regulates Jak2 kinase activity .
18160720	0	erythropoietin_receptor	38,61	Jak2	72,76	erythropoietin receptor	Jak2	2057	3717	Gene	Gene	interaction|nmod|START_ENTITY regulates|nsubj|interaction regulates|dobj|activity activity|amod|END_ENTITY	Jak2 FERM domain interaction with the erythropoietin_receptor regulates Jak2 kinase activity .
9923445	0	erythropoietin_receptor	8,31	Jak2	124,128	erythropoietin receptor	Jak2	2057	3717	Gene	Gene	mutant|compound|START_ENTITY associated|nsubjpass|mutant associated|nmod|deregulation deregulation|nmod|rates rates|nmod|END_ENTITY	A human erythropoietin_receptor gene mutant causing familial_erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation .
10660611	0	erythropoietin_receptor	84,107	Ship1	31,36	erythropoietin receptor	Ship1	2057	3635	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	The SH2_inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin_receptor .
22982397	0	erythropoietin_receptor	45,68	T-cell_acute_leukemia_1	0,23	erythropoietin receptor	T-cell acute leukemia 1	2057	6886	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	T-cell_acute_leukemia_1 -LRB- TAL1 -RRB- regulation of erythropoietin_receptor and association with excessive erythrocytosis .
22982397	0	erythropoietin_receptor	45,68	TAL1	25,29	erythropoietin receptor	TAL1	2057	6886	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	T-cell_acute_leukemia_1 -LRB- TAL1 -RRB- regulation of erythropoietin_receptor and association with excessive erythrocytosis .
18424770	0	erythropoietin_receptor	63,86	Wt1	28,31	erythropoietin receptor	Wt1	13857(Tax:10090)	22431(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	The Wilms ' _ tumor suppressor Wt1 activates transcription of the erythropoietin_receptor in hematopoietic progenitor cells .
11850847	0	erythropoietin_receptor	50,73	env	92,95	erythropoietin receptor	env	2057	30816	Gene	Gene	activation|compound|START_ENTITY activation|nmod|gene gene|compound|END_ENTITY	Oncogene cooperativity_in_Friend_erythroleukemia : erythropoietin_receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU .1 , independent of SFFV proviral insertion .
17912447	0	erythropoietin_receptor	45,68	erythropoietin	85,99	erythropoietin receptor	erythropoietin	2057	2056	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Glioblastoma multiforme cells : expression of erythropoietin_receptor and response to erythropoietin .
10397722	0	erythropoietin_receptor	48,71	glucocorticoid_receptor	4,27	erythropoietin receptor	glucocorticoid receptor	2057	2908	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The glucocorticoid_receptor cooperates with the erythropoietin_receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro .
2161534	0	erythropoietin_receptor	71,94	gp55	47,51	erythropoietin receptor	gp55	13857(Tax:10090)	27020	Gene	Gene	spleen_focus-forming_virus|nmod|START_ENTITY spleen_focus-forming_virus|dobj|interacts interacts|amod|END_ENTITY	Friend spleen_focus-forming_virus glycoprotein gp55 interacts with the erythropoietin_receptor in the endoplasmic reticulum and affects receptor metabolism .
9209415	0	erythropoietin_receptor	93,116	gp55	68,72	erythropoietin receptor	gp55	2057	27020	Gene	Gene	glycoprotein|nmod|START_ENTITY Activation|acl|glycoprotein Activation|nmod|END_ENTITY	Activation of the JAK1-STAT5 pathway by binding of the Friend virus gp55 glycoprotein to the erythropoietin_receptor .
17937286	0	esp	47,50	enterococcal_surface_protein	17,45	esp	enterococcal surface protein	246777	246777	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Incidence of the enterococcal_surface_protein -LRB- esp -RRB- gene in human and animal fecal sources .
19031895	0	esp	62,65	enterococcal_surface_protein	32,60	esp	enterococcal surface protein	246777	246777	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Environmental occurrence of the enterococcal_surface_protein -LRB- esp -RRB- gene is an unreliable indicator of human fecal contamination .
10600542	0	esp-1	23,28	PRSS_21	35,42	esp-1	PRSS 21	10942	10942	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural analysis of esp-1 gene -LRB- PRSS_21 -RRB- .
22048959	0	espin	23,28	Whirlin	0,7	espin	Whirlin	56226(Tax:10090)	73750(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Whirlin interacts with espin and modulates its actin-regulatory function : an insight into the mechanism of Usher_syndrome_type_II .
21199655	0	esr2a	52,57	estrogen_receptor_2a	30,50	esr2a	estrogen receptor 2a	317734(Tax:7955)	317734(Tax:7955)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	The knockdown of the maternal estrogen_receptor_2a -LRB- esr2a -RRB- mRNA affects embryo transcript contents and larval development in zebrafish .
1815957	0	esterase-1	28,38	ES-1	40,44	esterase-1	ES-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Determination of rat plasma esterase-1 -LRB- ES-1 -RRB- activity by scanning densitometry of gradient polyacrylamide gels with zymogram detection .
2093139	0	esterase-1	55,65	ES-1	67,71	esterase-1	ES-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Influence of dietary fats on butyrylcholinesterase and esterase-1 -LRB- ES-1 -RRB- activity in plasma of rats .
2396444	0	esterase-1	48,58	ES-1	60,64	esterase-1	ES-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Specific effect of the amount of dietary fat on esterase-1 -LRB- ES-1 -RRB- activity of rat plasma .
2747435	0	esterase-1	7,17	ES-1	19,23	esterase-1	ES-1	24841(Tax:10116)	24841(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Plasma esterase-1 -LRB- ES-1 -RRB- activity is increased in rats fed high-fat diets .
1883319	0	esterase_28	28,39	ES-28	41,46	esterase 28	ES-28	109612(Tax:10090)	109612(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Genetic characterization of esterase_28 -LRB- ES-28 -RRB- of the house_mouse .
2173625	0	estradiol_receptor	74,92	17_beta-hydroxysteroid_dehydrogenase	8,44	estradiol receptor	17 beta-hydroxysteroid dehydrogenase	24890(Tax:10116)	364773(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Role of 17_beta-hydroxysteroid_dehydrogenase in the modulation of nuclear estradiol_receptor binding by progesterone in the rat anterior pituitary gland and the uterus .
9204213	0	estradiol_receptor	145,163	ER	165,167	estradiol receptor	ER	2099	2099	Gene	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	Prognostic significance of c-erbB-2 / neu amplification and epidermal_growth_factor_receptor -LRB- EGFR -RRB- in primary breast_cancer and their relation to estradiol_receptor -LRB- ER -RRB- status .
8912864	0	estrogen	65,73	retinoic_acid_receptor_alpha	24,52	RARalpha	retinoic acid receptor alpha	5914	5914	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Regulation of the human retinoic_acid_receptor_alpha gene in the estrogen receptor negative human breast_carcinoma cell lines SKBR-3 and MDA-MB-435 .
20569503	0	estrogen-receptor	89,106	ER	108,110	estrogen-receptor	ER	2099	2099	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor -LRB- ER -RRB- levels and activity in ER + breast_cancer .
20650001	0	estrogen-receptor	74,91	PPARgamma	61,70	estrogen-receptor	PPARgamma	2099	5468	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast_cancer cells .
17509876	0	estrogen-related_receptor	24,49	ERR	51,54	estrogen-related receptor	ERR	6541	6541	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical implication of estrogen-related_receptor -LRB- ERR -RRB- expression in ovarian_cancers .
19416752	0	estrogen-related_receptor	24,49	ERR	51,54	estrogen-related receptor	ERR	6541	6541	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical implication of estrogen-related_receptor -LRB- ERR -RRB- expression in uterine endometrial_cancers .
9256346	0	estrogen-related_receptor_1	18,45	ERR-1	47,52	estrogen-related receptor 1	ERR-1	26379(Tax:10090)	26379(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of the estrogen-related_receptor_1 -LRB- ERR-1 -RRB- orphan receptor during mouse development .
25480584	0	estrogen-related_receptor_alpha	11,42	ERRa	44,48	estrogen-related receptor alpha	ERRa	2101	2101	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of estrogen-related_receptor_alpha -LRB- ERRa -RRB- on proliferation and metastasis of human lung_cancer A549 cells .
15184675	0	estrogen-related_receptor_alpha	72,103	ERRalpha	105,113	estrogen-related receptor alpha	ERRalpha	2101	2101	Gene	Gene	ligand|amod|START_ENTITY ligand|appos|END_ENTITY	Regulation of PPARgamma coactivator 1alpha -LRB- PGC-1alpha -RRB- signaling by an estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- ligand .
17294452	0	estrogen-related_receptor_alpha	24,55	ERRalpha	57,65	estrogen-related receptor alpha	ERRalpha	2101	2101	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- is a negative prognostic predictor in human prostate_cancer .
12522104	0	estrogen-related_receptor_alpha	107,138	PGC-1	32,37	estrogen-related receptor alpha	PGC-1	2101	10891	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related_receptor_alpha -LRB- ERRalpha -RRB- .
15878968	0	estrogen-related_receptor_alpha	83,114	SULT2A1	71,78	estrogen-related receptor alpha	SULT2A1	2101	6822	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- by estrogen-related_receptor_alpha .
15878968	0	estrogen-related_receptor_alpha	83,114	sulfotransferase	53,69	estrogen-related receptor alpha	sulfotransferase	2101	6822	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- by estrogen-related_receptor_alpha .
20923753	0	estrogen-related_receptor_beta	14,44	ERRb	46,50	estrogen-related receptor beta	ERRb	2103	2103	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of estrogen-related_receptor_beta -LRB- ERRb -RRB- in human skin .
18573717	0	estrogen-related_receptor_gamma	14,45	ERRgamma	47,55	estrogen-related receptor gamma	ERRgamma	2104	2104	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of estrogen-related_receptor_gamma -LRB- ERRgamma -RRB- in human skin .
15130519	0	estrogen-responsive_finger_protein	25,59	Efp	61,64	estrogen-responsive finger protein	Efp	7706	7706	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Systemic distribution of estrogen-responsive_finger_protein -LRB- Efp -RRB- in human tissues .
16140366	0	estrogen-responsive_finger_protein	14,48	Efp	50,53	estrogen-responsive finger protein	Efp	7706	7706	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of estrogen-responsive_finger_protein -LRB- Efp -RRB- is associated with advanced_disease in human epithelial ovarian_cancer .
9245730	0	estrogen-responsive_finger_protein	89,123	efp	125,128	estrogen-responsive finger protein	efp	7706	7706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple regulatory elements and binding proteins of the 5 ' - flanking region of the human estrogen-responsive_finger_protein -LRB- efp -RRB- gene .
9714786	0	estrogen-responsive_finger_protein	27,61	efp	63,66	estrogen-responsive finger protein	efp	217069(Tax:10090)	217069(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter analysis of mouse estrogen-responsive_finger_protein -LRB- efp -RRB- gene : mouse efp promoter contains an E-box that is also conserved in human .
19463120	0	estrogen_receptor	51,68	ACE	17,20	estrogen receptor	ACE	2099	1636	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	-LSB- Polymorphism of ACE , angiotensin_II , NO-synthase , estrogen_receptor genes and gender differences in their effects on development of cardiovascular_pathology -RSB- .
15496419	0	estrogen_receptor	20,37	ADA3	6,10	estrogen receptor	ADA3	2099	10474	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human ADA3 binds to estrogen_receptor -LRB- ER -RRB- and functions as a coactivator for ER-mediated transactivation .
23801113	0	estrogen_receptor	121,138	Apoptosis-antagonizing_transcription_factor	0,43	estrogen receptor	Apoptosis-antagonizing transcription factor	2099	26574	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Apoptosis-antagonizing_transcription_factor -LRB- AATF -RRB- gene silencing : role in induction of apoptosis and down-regulation of estrogen_receptor in breast_cancer cells .
23811274	0	estrogen_receptor	17,34	CITED2	0,6	estrogen receptor	CITED2	2099	10370	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	CITED2 modulates estrogen_receptor transcriptional activity in breast_cancer cells .
10619353	0	estrogen_receptor	8,25	COUP-TF	150,157	estrogen receptor	COUP-TF	2099	7025	Gene	Gene	Role|nmod|START_ENTITY ligand|nsubj|Role ligand|dep|END_ENTITY	Role of estrogen_receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor -LRB- COUP-TF -RRB- .
17638866	0	estrogen_receptor	67,84	Chk1	23,27	estrogen receptor	Chk1	2099	1111	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen_receptor / progesterone_receptor / HER-2 breast_carcinomas .
9271411	0	estrogen_receptor	25,42	Cyclin_D1	0,9	estrogen receptor	Cyclin D1	2099	595	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Cyclin_D1 stimulation of estrogen_receptor transcriptional activity independent of cdk4 .
10446910	0	estrogen_receptor	111,128	E2F1	30,34	estrogen receptor	E2F1	2099	1869	Gene	Gene	interactions|compound|START_ENTITY regulated|nmod|interactions regulated|nsubjpass|activation activation|nmod|expression expression|compound|END_ENTITY	Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1 / estrogen_receptor interactions .
11006500	0	estrogen_receptor	14,31	ER	33,35	estrogen receptor	ER	2099	2099	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of estrogen_receptor -LRB- ER -RRB- in oral mucosa and salivary glands .
11051252	0	estrogen_receptor	8,25	ER	27,29	estrogen receptor	ER	2099	2099	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Loss of estrogen_receptor -LRB- ER -RRB- expression in endometrial_tumors is not associated with de novo methylation of the 5 ' end of the ER gene .
11212261	0	estrogen_receptor	14,31	ER	33,35	estrogen receptor	ER	2099	2099	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of estrogen_receptor -LRB- ER -RRB- subtypes and ERbeta isoforms in colon_cancer .
1371912	0	estrogen_receptor	14,31	ER	33,35	estrogen receptor	ER	2099	2099	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Detection of estrogen_receptor -LRB- ER -RRB- mRNA by use of reverse transcriptase-polymerase chain reaction -LRB- RT-PCR -RRB- assay ; comparison with dextran coated charcoal -LRB- DCC -RRB- assay and immunocytochemical assay -RSB- .
17649823	0	estrogen_receptor	23,40	ER	42,44	estrogen receptor	ER	2099	2099	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms of human estrogen_receptor -LRB- ER -RRB- gene alpha and beta in prostate_cancer PC-EW and PC-OR cell lines .
17683929	0	estrogen_receptor	14,31	ER	33,35	estrogen receptor	ER	2099	2099	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Regulation of estrogen_receptor -LRB- ER -RRB- levels in MCF-7 cells by progesterone metabolites .
20143189	0	estrogen_receptor	263,280	ER	282,284	estrogen receptor	ER	2099	2099	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Breast density , scintimammographic -LRB- 99m -RRB- Tc -LRB- V -RRB- DMSA uptake , and calcitonin_gene_related_peptide -LRB- CGRP -RRB- expression in mixed invasive ductal associated with extensive in __ situ_ductal_carcinoma -LRB- IDC + DCIS -RRB- and pure_invasive_ductal_carcinoma -LRB- IDC -RRB- : correlation with estrogen_receptor -LRB- ER -RRB- status , proliferation index Ki-67 , and histological grade .
2097642	0	estrogen_receptor	36,53	ER	55,57	estrogen receptor	ER	2099	2099	Gene	Gene	status|appos|START_ENTITY status|appos|END_ENTITY	Correlations among receptor status , estrogen_receptor -LRB- ER -RRB- form -LRB- 8S and/or 4S -RRB- and labelling index -LRB- LI -RRB- in human breast cancer .
25614118	0	estrogen_receptor	61,78	ER	80,82	estrogen receptor	ER	2099	2099	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Structure-activity relationship study of diphenylamine-based estrogen_receptor -LRB- ER -RRB- antagonists .
4092577	0	estrogen_receptor	67,84	ER	86,88	estrogen receptor	ER	2099	2099	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	-LSB- The influence and significance of obtaining , storing and assay on estrogen_receptor -LRB- ER -RRB- content in breast_cancer tissue -RSB- .
8702313	0	estrogen_receptor	27,44	ER	46,48	estrogen receptor	ER	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Molecular analysis of the estrogen_receptor -LRB- ER -RRB- gene in association with ER negativity in breast_cancer -RSB- .
8919544	0	estrogen_receptor	51,68	ER	77,79	estrogen receptor	ER	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Sequence analysis of the DNA binding domain of the estrogen_receptor gene in ER -LRB- + -RRB- / PR -LRB- - -RRB- breast_cancer .
8973592	0	estrogen_receptor	25,42	ER	44,46	estrogen receptor	ER	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence variants of the estrogen_receptor -LRB- ER -RRB- gene found in breast_cancer patients with ER negative and progesterone_receptor positive tumors .
22461216	0	estrogen_receptor	38,55	ER-a	57,61	estrogen receptor	ER-a	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of osteoprotegerin -LRB- OPG -RRB- and estrogen_receptor -LRB- ER-a -RRB- gene polymorphisms in rheumatoid_arthritis .
11752866	0	estrogen_receptor	14,31	ER-alpha	33,41	estrogen receptor	ER-alpha	2099	2099	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of estrogen_receptor -LRB- ER-alpha and ER-beta -RRB- mRNA in human prostate_cancer .
19878085	0	estrogen_receptor	30,47	ERbeta	59,65	estrogen receptor	ERbeta	2099	2100	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	+1730 _ G/A polymorphism of the estrogen_receptor beta gene -LRB- ERbeta -RRB- may be an important genetic factor predisposing to endometriosis .
11192427	0	estrogen_receptor	23,40	ESR	41,44	estrogen receptor	ESR	100737874	100737874	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- The genetic effect of estrogen_receptor -LRB- ESR -RRB- on litter size traits in pig -RSB- .
14617832	0	estrogen_receptor	47,64	ESR	71,74	estrogen receptor	ESR	100737874	100737874	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relation between Ava I polymorphism within the estrogen_receptor gene -LRB- ESR -RRB- and meatiness in Polish Large White boars .
18704709	0	estrogen_receptor	29,46	ESR2	53,57	estrogen receptor	ESR2	2099	2100	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms in the estrogen_receptor beta -LRB- ESR2 -RRB- gene and the risk of epithelial_ovarian_carcinoma .
20351197	0	estrogen_receptor	68,85	EZH2	35,39	estrogen receptor	EZH2	2099	2146	Gene	Gene	methylation|nmod|START_ENTITY methylation|compound|END_ENTITY	Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen_receptor signaling to PI3K/AKT .
7760810	0	estrogen_receptor	80,97	GATA-1	66,72	estrogen receptor	GATA-1	2099	2623	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen_receptor .
10096242	0	estrogen_receptor	40,57	GATA-3	0,6	estrogen receptor	GATA-3	2099	2625	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	GATA-3 is expressed in association with estrogen_receptor in breast_cancer .
23814048	0	estrogen_receptor	49,66	GR	40,42	estrogen receptor	GR	2099	2908	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
17666587	0	estrogen_receptor	34,51	GREB1	25,30	estrogen receptor	GREB1	2099	9687	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Long-range activation of GREB1 by estrogen_receptor via three distal consensus estrogen-responsive elements in breast_cancer cells .
9506965	0	estrogen_receptor	144,161	GRIP-1	77,83	estrogen receptor	GRIP-1	2099	23426	Gene	Gene	pharmacology|compound|START_ENTITY determining|dobj|pharmacology highlights|advcl|determining highlights|nsubj|Enhancement Enhancement|nmod|activity activity|nmod|END_ENTITY	Enhancement of estrogen_receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation_function_2 in determining estrogen_receptor pharmacology .
9506965	0	estrogen_receptor	15,32	GRIP-1	77,83	estrogen receptor	GRIP-1	2099	23426	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Enhancement of estrogen_receptor transcriptional activity by the coactivator GRIP-1 highlights the role of activation_function_2 in determining estrogen_receptor pharmacology .
19515975	0	estrogen_receptor	31,48	H2A.Z	8,13	estrogen receptor	H2A.Z	2099	3015	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Histone H2A.Z is essential for estrogen_receptor signaling .
23818346	0	estrogen_receptor	27,44	HER2/neu	69,77	estrogen receptor	HER2/neu	2099	2064	Gene	Gene	Ki-67|compound|START_ENTITY Ki-67|dep|END_ENTITY	Prognostic significance of estrogen_receptor , progesterone_receptor , HER2/neu , Ki-67 , and nm23 expression in patients with invasive_breast_cancer .
9523727	0	estrogen_receptor	61,78	ICERE-1	91,98	estrogen receptor	ICERE-1	2099	1687	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Characterization of a gene that is inversely correlated with estrogen_receptor expression -LRB- ICERE-1 -RRB- in breast_carcinomas .
14989985	0	estrogen_receptor	61,78	K-ras4B	22,29	estrogen receptor	K-ras4B	2099	3845	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	-LSB- Regulation of -LSB- 12Asp -RSB- K-ras4B on transcriptional activity of estrogen_receptor in endometrial_carcinoma HEC-1A cell lines -RSB- .
25488809	0	estrogen_receptor	46,63	KDM3A	31,36	estrogen receptor	KDM3A	2099	55818	Gene	Gene	regulator|compound|START_ENTITY regulator|nsubj|END_ENTITY	The histone demethylase enzyme KDM3A is a key estrogen_receptor regulator in breast_cancer .
17006958	0	estrogen_receptor	41,58	MS-KIF18A	0,9	estrogen receptor	MS-KIF18A	2099	81930	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	MS-KIF18A , a kinesin , is associated with estrogen_receptor .
7641693	0	estrogen_receptor	66,83	Nuclear_factor_RIP140	0,21	estrogen receptor	Nuclear factor RIP140	2099	8204	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Nuclear_factor_RIP140 modulates transcriptional activation by the estrogen_receptor .
11429412	0	estrogen_receptor	140,157	PIAS3	193,198	estrogen receptor	PIAS3	2099	10401	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Activation of estrogen_receptor blocks interleukin-6-inducible cell growth of human multiple_myeloma involving molecular cross-talk between estrogen_receptor and STAT3 mediated by co-regulator PIAS3 .
17599055	0	estrogen_receptor	54,71	Per2	15,19	estrogen receptor	Per2	2099	8864	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	The clock gene Per2 links the circadian system to the estrogen_receptor .
12743151	0	estrogen_receptor	76,93	Progesterone_receptor	0,21	estrogen receptor	Progesterone receptor	2099	5241	Gene	Gene	status|compound|START_ENTITY prediction|nmod|status improves|dobj|prediction improves|nsubj|status status|amod|END_ENTITY	Progesterone_receptor status significantly improves outcome prediction over estrogen_receptor status alone for adjuvant endocrine therapy in two large breast_cancer databases .
25778292	0	estrogen_receptor	61,78	Progesterone_receptor	0,21	estrogen receptor	Progesterone receptor	2099	5241	Gene	Gene	positive|amod|START_ENTITY patients|amod|positive prognosis|nmod|patients determining|dobj|prognosis END_ENTITY|advcl|determining	Progesterone_receptor status in determining the prognosis of estrogen_receptor positive / HER2 negative breast_carcinoma patients .
10938099	0	estrogen_receptor	39,56	Prothymosin_alpha	0,17	estrogen receptor	Prothymosin alpha	2099	100506248	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Prothymosin_alpha selectively enhances estrogen_receptor transcriptional activity by interacting with a repressor_of_estrogen_receptor_activity .
26158350	0	estrogen_receptor	21,38	SERPINA1	0,8	estrogen receptor	SERPINA1	2099	5265	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	SERPINA1 is a direct estrogen_receptor target gene and a predictor of survival in breast_cancer patients .
22820659	0	estrogen_receptor	25,42	SP1	60,63	estrogen receptor	SP1	2099	6667	Gene	Gene	expression|compound|START_ENTITY analysis|nmod|expression shows|nsubj|analysis shows|ccomp|sensitive sensitive|nsubj|antibody antibody|compound|END_ENTITY	Quantitative analysis of estrogen_receptor expression shows SP1 antibody is more sensitive than 1D5 .
7760849	0	estrogen_receptor	21,38	SPT6	51,55	estrogen receptor	SPT6	2099	6830	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Enhancement of human estrogen_receptor activity by SPT6 : a potential coactivator .
10369408	0	estrogen_receptor	64,81	Sex_hormone_binding_globulin	0,28	estrogen receptor	Sex hormone binding globulin	2099	6462	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Sex_hormone_binding_globulin expression and colocalization with estrogen_receptor in the human Fallopian tube .
8923463	0	estrogen_receptor	8,25	Sp1	26,29	estrogen receptor	Sp1	2099	6667	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|END_ENTITY	Role of estrogen_receptor / Sp1 complexes in estrogen-induced heat_shock protein 27 gene expression .
9528985	0	estrogen_receptor	92,109	Sp1	110,113	estrogen receptor	Sp1	2099	6667	Gene	Gene	formation|compound|START_ENTITY formation|compound|END_ENTITY	Estrogen-induced c-fos protooncogene expression in MCF-7 human breast_cancer cells : role of estrogen_receptor Sp1 complex formation .
3013349	0	estrogen_receptor	50,67	Transferrin_receptor	0,20	estrogen receptor	Transferrin receptor	2099	7037	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|END_ENTITY	Transferrin_receptor is inversely correlated with estrogen_receptor in breast_cancer .
2153347	0	estrogen_receptor	73,90	Vimentin	0,8	estrogen receptor	Vimentin	2099	7431	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Vimentin is preferentially expressed in human breast_carcinomas with low estrogen_receptor and high Ki-67 growth fraction .
25487922	0	estrogen_receptor	78,95	b-catenin	14,23	estrogen receptor	b-catenin	2099	1499	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of b-catenin stimulated by mechanical strain and estrogen requires estrogen_receptor in mesenchymal stem cells -LRB- MSCs -RRB- .
12088102	0	estrogen_receptor	78,95	c-erbB-2	14,22	estrogen receptor	c-erbB-2	2099	2064	Gene	Gene	status|compound|START_ENTITY correlate|nmod|status correlate|nsubj|Expression Expression|nmod|END_ENTITY	Expression of c-erbB-2 in node negative breast_cancer does not correlate with estrogen_receptor status , predictors of hormone responsiveness , or PCNA expression .
12598915	0	estrogen_receptor	24,41	c-erbB-2	54,62	estrogen receptor	c-erbB-2	2099	2064	Gene	Gene	START_ENTITY|dobj|overexpression overexpression|amod|END_ENTITY	Angiogenesis relates to estrogen_receptor negativity , c-erbB-2 overexpression and early relapse in node-negative ductal_carcinoma_of_the_breast .
16608856	0	estrogen_receptor	18,35	cyclin_G2	46,55	estrogen receptor	cyclin G2	2099	901	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|amod|END_ENTITY	Estrogen-occupied estrogen_receptor represses cyclin_G2 gene expression and recruits a repressor complex at the cyclin_G2 promoter .
23814048	0	estrogen_receptor	49,66	glucocorticoid_receptor	15,38	estrogen receptor	glucocorticoid receptor	2099	2908	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
7651415	0	estrogen_receptor	44,61	interleukin-6	18,31	estrogen receptor	interleukin-6	2099	3569	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Repression of the interleukin-6 promoter by estrogen_receptor is mediated by NF-kappa_B and C/EBP _ beta .
16091743	0	estrogen_receptor	52,69	liver_receptor_homolog-1	21,45	estrogen receptor	liver receptor homolog-1	2099	26424(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	The nuclear receptor liver_receptor_homolog-1 is an estrogen_receptor target gene .
20607599	0	estrogen_receptor	39,56	liver_receptor_homolog-1	4,28	estrogen receptor	liver receptor homolog-1	2099	2494	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The liver_receptor_homolog-1 regulates estrogen_receptor expression in breast_cancer cells .
1358436	0	estrogen_receptor	75,92	neu	34,37	estrogen receptor	neu	2099	2064	Gene	Gene	stimulated|dobj|START_ENTITY estrogen|acl|stimulated protooncogene|nmod|estrogen protooncogene|nsubj|repression repression|nmod|END_ENTITY	Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen_receptor .
23255089	0	estrogen_receptor	14,31	neu	67,70	estrogen receptor	neu	2099	2064	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of estrogen_receptor , progesterone_receptor , and Her-2 / _ neu in primary and extra-corporeal endometrial_cancer .
24168506	0	estrogen_receptor	10,27	neu	62,65	Estrogen receptor	neu	2099	2064	Gene	Gene	progesterone_receptor|compound|START_ENTITY Review|nmod|progesterone_receptor END_ENTITY|nsubj|Review	Review of estrogen_receptor , progesterone_receptor , and HER-2 / neu immunohistochemistry impacts on treatment for a small subset of breast_cancer patients transferring care to another institution .
10719737	0	estrogen_receptor	56,73	p53	30,33	estrogen receptor	p53	2099	7157	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Distinct prognostic values of p53 mutations and loss of estrogen_receptor and their cumulative effect in primary breast_cancers .
10914818	0	estrogen_receptor	161,178	p53	152,155	estrogen receptor	p53	2099	7157	Gene	Gene	ER|appos|START_ENTITY END_ENTITY|appos|ER	Microsatellite alterations on human chromosome 11 in in situ and invasive breast_cancer : a microdissection microsatellite analysis and correlation with p53 , ER -LRB- estrogen_receptor -RRB- , and PR -LRB- progesterone_receptor -RRB- protein immunoreactivity .
15183535	0	estrogen_receptor	56,73	p53	15,18	estrogen receptor	p53	2099	7157	Gene	Gene	risk|amod|START_ENTITY Association|nmod|risk Association|nmod|polymorphism polymorphism|compound|END_ENTITY	Association of p53 genetic polymorphism -LRB- Arg72Pro -RRB- with estrogen_receptor positive breast_cancer risk in Japanese women .
20696891	0	estrogen_receptor	14,31	p53	50,53	estrogen receptor	p53	2099	7157	Gene	Gene	Mechanisms|nmod|START_ENTITY antagonism|nsubj|Mechanisms antagonism|nmod|END_ENTITY	Mechanisms of estrogen_receptor antagonism toward p53 and its implications in breast_cancer therapeutic response and stem cell regulation .
22787161	0	estrogen_receptor	17,34	p53	0,3	estrogen receptor	p53	2099	7157	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	p53 , a target of estrogen_receptor -LRB- ER -RRB- a , modulates DNA damage-induced growth suppression in ER-positive breast_cancer cells .
23242655	0	estrogen_receptor	20,37	p53	7,10	estrogen receptor	p53	2099	7157	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Mutant p53 binds to estrogen_receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast_cancer cells .
8098318	0	estrogen_receptor	110,127	p53	0,3	estrogen receptor	p53	2099	7157	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein relationship|nmod|expression expression|dep|relationship expression|compound|END_ENTITY	p53 protein expression in mammary ductal_carcinoma_in_situ : relationship to immunohistochemical expression of estrogen_receptor and c-erbB-2 protein .
9344880	0	estrogen_receptor	52,69	p53	21,24	estrogen receptor	p53	2099	7157	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The tumor suppressor p53 is a negative regulator of estrogen_receptor signaling pathways .
10678068	0	estrogen_receptor	61,78	progesterone_receptor	80,101	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	prediction|amod|START_ENTITY END_ENTITY|nsubj|prediction	-LSB- Prognosis prediction of S-phase fraction and p53 , c-erbB-2 , estrogen_receptor , progesterone_receptor in axillary node-negative breast_cancer -RSB- .
12208729	0	estrogen_receptor	14,31	progesterone_receptor	117,138	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	Expression|nmod|START_ENTITY cx|nsubj|Expression cx|xcomp|breast_cancer breast_cancer|dep|correlation correlation|nmod|END_ENTITY	Expression of estrogen_receptor -LRB- ER -RRB- -LRB- beta -RRB- cx protein in ER -LRB- alpha -RRB- - positive breast_cancer : specific correlation with progesterone_receptor .
12385821	0	estrogen_receptor	29,46	progesterone_receptor	60,81	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Transdominant suppression of estrogen_receptor signaling by progesterone_receptor ligands in uterine leiomyoma cells .
15084345	0	estrogen_receptor	23,40	progesterone_receptor	99,120	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|dep|expression expression|nmod|B-isoform B-isoform|amod|END_ENTITY	Molecular mechanism of estrogen_receptor -LRB- ER -RRB- alpha-specific , estradiol-dependent expression of the progesterone_receptor -LRB- PR -RRB- B-isoform .
17387718	0	estrogen_receptor	24,41	progesterone_receptor	57,78	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|negative negative|appos|END_ENTITY	Descriptive analysis of estrogen_receptor -LRB- ER -RRB- - negative , progesterone_receptor -LRB- PR -RRB- - negative , and HER2-negative invasive breast_cancer , the so-called triple-negative phenotype : a population-based study from the California_cancer Registry .
17638866	0	estrogen_receptor	67,84	progesterone_receptor	86,107	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	expressed|nmod|START_ENTITY END_ENTITY|dep|expressed	The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen_receptor / progesterone_receptor / HER-2 breast_carcinomas .
18413639	0	estrogen_receptor	38,55	progesterone_receptor	57,78	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	approximated|nmod|START_ENTITY approximated|advmod|END_ENTITY	Breast_cancer subtype approximated by estrogen_receptor , progesterone_receptor , and HER-2 is associated with local and distant recurrence after breast-conserving therapy .
1846309	0	estrogen_receptor	36,53	progesterone_receptor	55,76	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	determination|nmod|START_ENTITY determination|appos|END_ENTITY	Immunocytochemical determination of estrogen_receptor , progesterone_receptor , and_1 ,25 - dihydroxyvitamin_D3 receptor in breast_cancer and relationship to prognosis .
2018347	0	estrogen_receptor	22,39	progesterone_receptor	87,108	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	gene|compound|START_ENTITY change|nmod|gene associated|nsubj|change associated|nmod|expression expression|nmod|END_ENTITY	Somatic change in the estrogen_receptor gene associated with altered expression of the progesterone_receptor .
22931039	0	estrogen_receptor	13,30	progesterone_receptor	46,67	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	Frequency|nmod|START_ENTITY Frequency|dep|negative negative|appos|END_ENTITY	Frequency of estrogen_receptor -LRB- ER -RRB- - negative , progesterone_receptor -LRB- PR -RRB- - negative , and HER2-negative invasive breast_cancer , the so-called triple-negative phenotype : a population-based study from Trentino , North East Italy .
23818346	0	estrogen_receptor	27,44	progesterone_receptor	46,67	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	Ki-67|compound|START_ENTITY Ki-67|dep|END_ENTITY	Prognostic significance of estrogen_receptor , progesterone_receptor , HER2/neu , Ki-67 , and nm23 expression in patients with invasive_breast_cancer .
24570392	0	estrogen_receptor	108,125	progesterone_receptor	52,73	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	that|nmod|START_ENTITY higher|nmod|that higher|nsubj|expression expression|nmod|END_ENTITY	In pulmonary_lymphangioleiomyomatosis expression of progesterone_receptor is frequently higher than that of estrogen_receptor .
6261932	0	estrogen_receptor	82,99	progesterone_receptor	125,146	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	START_ENTITY|dep|localization localization|nmod|END_ENTITY	Most cystosarcoma_phyllodes and fibroadenomas have progesterone_receptor but lack estrogen_receptor : stromal localization of progesterone_receptor .
8745507	0	estrogen_receptor	38,55	progesterone_receptor	57,78	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	proliferation|compound|START_ENTITY proliferation|dep|END_ENTITY	-LSB- Research on the relationship between estrogen_receptor , progesterone_receptor , cell proliferation associated antigen in uterine leiomyoma and nuclear body density of myoma , serum reproductive hormone concentrations -RSB- .
8986784	0	estrogen_receptor	83,100	progesterone_receptor	38,59	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	occupancy|compound|START_ENTITY parallel|dobj|occupancy parallel|nsubj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Estrogen-induced transcription of the progesterone_receptor gene does not parallel estrogen_receptor occupancy .
9524123	0	estrogen_receptor	86,103	progesterone_receptor	44,65	estrogen receptor	progesterone receptor	2099	5241	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|pathway pathway|nmod|END_ENTITY	Activation of the Src/p21ras/Erk pathway by progesterone_receptor via cross-talk with estrogen_receptor .
9075708	0	estrogen_receptor	65,82	transforming_growth_factor-beta	12,43	estrogen receptor	transforming growth factor-beta	2099	7040	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression role|nmod|regulation role|nmod|END_ENTITY	The role of transforming_growth_factor-beta in the regulation of estrogen_receptor expression in the MCF-7_breast_cancer cell line .
24550401	0	estrogen_receptor-a	16,35	IQGAP1	0,6	estrogen receptor-a	IQGAP1	2099	8826	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	IQGAP1 binds to estrogen_receptor-a and modulates its function .
22737185	0	estrogen_receptor-a	23,42	WT1	97,100	estrogen receptor-a	WT1	2099	7490	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Opposite regulation of estrogen_receptor-a and its variant ER-a36 by the Wilms ' _ tumor suppressor WT1 .
23408138	0	estrogen_receptor-a	27,46	miR-342	0,7	estrogen receptor-a	miR-342	2099	442909	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	miR-342 is associated with estrogen_receptor-a expression and response to tamoxifen in breast_cancer .
19638585	0	estrogen_receptor-alpha	27,50	Androgen_receptor	0,17	estrogen receptor-alpha	Androgen receptor	2099	367	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Androgen_receptor inhibits estrogen_receptor-alpha activity and is prognostic in breast_cancer .
16037132	0	estrogen_receptor-alpha	109,132	CHIP	0,4	estrogen receptor-alpha	CHIP	2099	358	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	CHIP -LRB- carboxyl_terminus_of_Hsc70-interacting_protein -RRB- promotes basal and geldanamycin-induced degradation of estrogen_receptor-alpha .
19661335	0	estrogen_receptor-alpha	43,66	ER-alpha	68,76	estrogen receptor-alpha	ER-alpha	2099	2099	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
16249893	0	estrogen_receptor-alpha	25,48	ERalpha	50,57	estrogen receptor-alpha	ERalpha	2099	2099	Gene	Gene	and|compound|START_ENTITY and|appos|END_ENTITY	Cellular localization of estrogen_receptor-alpha -LRB- ERalpha -RRB- and - beta -LRB- ERbeta -RRB- mRNA in the boar testis .
19936541	0	estrogen_receptor-alpha	10,33	ESR1	35,39	estrogen receptor-alpha	ESR1	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effect of estrogen_receptor-alpha -LRB- ESR1 -RRB- gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy .
20080637	0	estrogen_receptor-alpha	33,56	ESR1	58,62	estrogen receptor-alpha	ESR1	2099	2099	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MYCN-regulated microRNAs repress estrogen_receptor-alpha -LRB- ESR1 -RRB- expression and neuronal differentiation in human neuroblastoma .
22913342	0	estrogen_receptor-alpha	42,65	ESR1	67,71	estrogen receptor-alpha	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cohesin is required for expression of the estrogen_receptor-alpha -LRB- ESR1 -RRB- gene .
19797124	0	estrogen_receptor-alpha	79,102	Foxl2	0,5	estrogen receptor-alpha	Foxl2	2099	668	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Foxl2 , a forkhead transcription factor , modulates nonclassical activity of the estrogen_receptor-alpha .
19661335	0	estrogen_receptor-alpha	43,66	Keratinocyte_growth_factor	0,26	estrogen receptor-alpha	Keratinocyte growth factor	2099	2252	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
12374744	0	estrogen_receptor-alpha	57,80	P21-activated_kinase-1	0,22	estrogen receptor-alpha	P21-activated kinase-1	13982(Tax:10090)	18479(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	P21-activated_kinase-1 phosphorylates and transactivates estrogen_receptor-alpha and promotes hyperplasia in mammary epithelium .
16452229	0	estrogen_receptor-alpha	37,60	P21-activated_kinase_1	0,22	estrogen receptor-alpha	P21-activated kinase 1	2099	5058	Gene	Gene	activation|amod|START_ENTITY regulation|nmod|activation regulation|amod|END_ENTITY	P21-activated_kinase_1 regulation of estrogen_receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation .
19433264	0	estrogen_receptor-alpha	19,42	PCB	64,67	estrogen receptor-alpha	PCB	2099	5091	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	Protective role of estrogen_receptor-alpha on lower chlorinated PCB congener-induced DNA damage and repair in human tumoral breast cells .
18755791	0	estrogen_receptor-alpha	32,55	Runx2	14,19	estrogen receptor-alpha	Runx2	2099	860	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Modulation of Runx2 activity by estrogen_receptor-alpha : implications for osteoporosis and breast_cancer .
19458056	0	estrogen_receptor-alpha	31,54	TFAP2C	15,21	estrogen receptor-alpha	TFAP2C	2099	7022	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Interaction of TFAP2C with the estrogen_receptor-alpha promoter is controlled by chromatin structure .
17205307	0	estrogen_receptor-alpha	61,84	androgen_receptor	14,31	estrogen receptor-alpha	androgen receptor	443228(Tax:9940)	443042(Tax:9940)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of androgen_receptor and its co-localization with estrogen_receptor-alpha in the developing pituitary gland of sheep fetus .
15637314	0	estrogen_receptor-alpha	59,82	angiopoietin-1	20,34	estrogen receptor-alpha	angiopoietin-1	13982(Tax:10090)	11600(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Estradiol regulates angiopoietin-1 mRNA expression through estrogen_receptor-alpha in a rodent experimental stroke model .
12011094	0	estrogen_receptor-alpha	57,80	hER_alpha	82,91	estrogen receptor-alpha	hER alpha	2099	26284	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Natural trans-spliced mRNAs are generated from the human estrogen_receptor-alpha -LRB- hER_alpha -RRB- gene .
16628468	0	estrogen_receptor-alpha	15,38	hTNF-alpha	52,62	estrogen receptor-alpha	hTNF-alpha	2099	7124	Gene	Gene	up-regulates|nsubj|START_ENTITY up-regulates|dobj|expression expression|amod|END_ENTITY	Over-expressed estrogen_receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon_cancer cells .
15012604	0	estrogen_receptor-alpha	14,37	p53	78,81	estrogen receptor-alpha	p53	2099	7157	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of estrogen_receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells .
16229810	0	estrogen_receptor-alpha	3,26	p53	150,153	estrogen receptor-alpha	p53	2099	7157	Gene	Gene	START_ENTITY|parataxis|activates activates|ccomp|Jun/Fos Jun/Fos|dobj|factors factors|dep|effects effects|nmod|END_ENTITY	An estrogen_receptor-alpha / p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors : repressive effects of p53 on BRCA-1 transcription .
19351845	0	estrogen_receptor-alpha	30,53	p53	57,60	estrogen receptor-alpha	p53	2099	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of estrogen_receptor-alpha by p53 in human breast_cancer cells .
17699777	0	estrogen_receptor-alpha	25,48	pRb	52,55	estrogen receptor-alpha	pRb	2099	5925	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Epigenetic modulation of estrogen_receptor-alpha by pRb family proteins : a novel mechanism in breast_cancer .
22186418	0	estrogen_receptor-b	50,69	ERb	71,74	estrogen receptor-b	ERb	13983(Tax:10090)	13983(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Anxiolytic effects and neuroanatomical targets of estrogen_receptor-b -LRB- ERb -RRB- activation by a selective ERb agonist in female mice .
9348186	0	estrogen_receptor-beta	87,109	ERbeta	111,117	estrogen receptor-beta	ERbeta	13983(Tax:10090)	13983(Tax:10090)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Tissue distribution and quantitative analysis of estrogen_receptor-alpha -LRB- ERalpha -RRB- and estrogen_receptor-beta -LRB- ERbeta -RRB- messenger ribonucleic_acid in the wild-type and ERalpha-knockout mouse .
17706602	0	estrogen_receptor-related_receptor_gamma	79,119	Polo-like_kinase_2	0,18	estrogen receptor-related receptor gamma	Polo-like kinase 2	2104	10769	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Polo-like_kinase_2 gene expression is regulated by the orphan nuclear receptor estrogen_receptor-related_receptor_gamma -LRB- ERRgamma -RRB- .
25981900	0	estrogen_receptor_1	10,29	ESR1	31,35	estrogen receptor 1	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Status of estrogen_receptor_1 -LRB- ESR1 -RRB- gene in mastopathy predicts subsequent development of breast_cancer .
25981900	0	estrogen_receptor_1	10,29	ESR1	31,35	estrogen receptor 1	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Status of estrogen_receptor_1 -LRB- ESR1 -RRB- gene in mastopathy predicts subsequent development of breast_cancer .
21199655	0	estrogen_receptor_2a	30,50	esr2a	52,57	estrogen receptor 2a	esr2a	317734(Tax:7955)	317734(Tax:7955)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The knockdown of the maternal estrogen_receptor_2a -LRB- esr2a -RRB- mRNA affects embryo transcript contents and larval development in zebrafish .
24282178	0	estrogen_receptor_I	25,44	ESR1	51,55	estrogen receptor I	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of the estrogen_receptor_I gene -LRB- ESR1 -RRB- in anorexia_nervosa_and_eating_disorders : no replication found .
23213263	0	estrogen_receptor_a	58,77	AF-1	41,45	estrogen receptor a	AF-1	13982(Tax:10090)	19185(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Transactivating function -LRB- AF -RRB- 2-mediated AF-1 activity of estrogen_receptor_a is crucial to maintain male reproductive tract function .
23580568	0	estrogen_receptor_a	32,51	AF-1	4,8	estrogen receptor a	AF-1	13982(Tax:10090)	19185(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|compound|END_ENTITY	The AF-1 activation function of estrogen_receptor_a is necessary and sufficient for uterine epithelial cell proliferation in vivo .
25452582	0	estrogen_receptor_a	69,88	AF-1	143,147	estrogen receptor a	AF-1	2099	3460	Gene	Gene	coactivator|compound|START_ENTITY acts|nmod|coactivator acts|nmod|domain domain|appos|END_ENTITY	Retraction : ' A subfamily of RNA-binding DEAD-box proteins acts as an estrogen_receptor_a coactivator through the N-terminal activation domain -LRB- AF-1 -RRB- with an RNA coactivator , SRA ' .
25860340	0	estrogen_receptor_a	36,55	Clathrin_heavy_chain	0,20	estrogen receptor a	Clathrin heavy chain	2099	1213	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Clathrin_heavy_chain interacts with estrogen_receptor_a and modulates 17b-estradiol signaling .
21837769	0	estrogen_receptor_a	41,60	ESR1	62,66	estrogen receptor a	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A cis-acting regulatory variation of the estrogen_receptor_a -LRB- ESR1 -RRB- gene is associated with hepatitis_B_virus-related liver cirrhosis .
23874775	0	estrogen_receptor_a	42,61	Ets1	21,25	estrogen receptor a	Ets1	2099	2113	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Transcription factor Ets1 cooperates with estrogen_receptor_a to stimulate estradiol-dependent growth in breast_cancer_cells_and_tumors .
21451544	0	estrogen_receptor_a	32,51	Fli1	0,4	estrogen receptor a	Fli1	13982(Tax:10090)	14247(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Fli1 is a negative regulator of estrogen_receptor_a in dermal fibroblasts .
22291950	0	estrogen_receptor_a	41,60	PRSS23	16,22	estrogen receptor a	PRSS23	2099	11098	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Serine_protease PRSS23 is upregulated by estrogen_receptor_a and associated with proliferation of breast_cancer cells .
24742914	0	estrogen_receptor_a	92,111	Protein_arginine_methyltransferase_6	0,36	estrogen receptor a	Protein arginine methyltransferase 6	2099	55170	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Protein_arginine_methyltransferase_6 enhances ligand-dependent and - independent activity of estrogen_receptor_a via distinct mechanisms .
25218501	0	estrogen_receptor_a	53,72	glutathione_S-transferase_P1-1	6,36	estrogen receptor a	glutathione S-transferase P1-1	2099	2950	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Human glutathione_S-transferase_P1-1 functions as an estrogen_receptor_a signaling modulator .
24413532	0	estrogen_receptor_a	27,46	metastasis-associated_protein_1	84,115	estrogen receptor a	metastasis-associated protein 1	2099	9112	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of estrogen_receptor_a expression in breast_cancer cells by metastasis-associated_protein_1 .
21211522	0	estrogen_receptor_a	4,23	proopiomelanocortin	41,60	estrogen receptor a	proopiomelanocortin	13982(Tax:10090)	18976(Tax:10090)	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	The estrogen_receptor_a colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2 .
23857051	0	estrogen_receptor_a	11,30	visfatin	58,66	estrogen receptor a	visfatin	2099	10135	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of estrogen_receptor_a and b on the expression of visfatin and retinol-binding_protein_4 in 3T3-L1 adipocytes .
16271083	0	estrogen_receptor_alpha	50,73	14-3-3_sigma	11,23	estrogen receptor alpha	14-3-3 sigma	2099	2810	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Increasing 14-3-3_sigma expression with declining estrogen_receptor_alpha and estrogen-responsive_finger_protein expression defines malignant progression of endometrial_carcinoma .
11250900	0	estrogen_receptor_alpha	56,79	AF-1	134,138	estrogen receptor alpha	AF-1	2099	3460	Gene	Gene	coactivator|compound|START_ENTITY acts|nmod|coactivator acts|nmod|domain domain|appos|END_ENTITY	A subfamily of RNA-binding DEAD-box proteins acts as an estrogen_receptor_alpha coactivator through the N-terminal activation domain -LRB- AF-1 -RRB- with an RNA coactivator , SRA .
15040833	0	estrogen_receptor_alpha	50,73	BMP-6	32,37	estrogen receptor alpha	BMP-6	2099	654	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional regulation of a BMP-6 promoter by estrogen_receptor_alpha .
20360387	0	estrogen_receptor_alpha	80,103	CARM1	0,5	estrogen receptor alpha	CARM1	2099	10498	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	CARM1 mediates the ligand-independent and tamoxifen-resistant activation of the estrogen_receptor_alpha by cAMP .
14508827	0	estrogen_receptor_alpha	25,48	CYP19	50,55	estrogen receptor alpha	CYP19	2099	1588	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Genetic polymorphisms of estrogen_receptor_alpha , CYP19 , catechol-O-methyltransferase are associated with familial_prostate_carcinoma risk in a Japanese population .
18524472	0	estrogen_receptor_alpha	40,63	Calmodulin	0,10	estrogen receptor alpha	Calmodulin	2099	808	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Calmodulin , a regulatory partner of the estrogen_receptor_alpha in breast_cancer cells .
10559241	0	estrogen_receptor_alpha	23,46	Caveolin-1	0,10	estrogen receptor alpha	Caveolin-1	2099	857	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	Caveolin-1 potentiates estrogen_receptor_alpha -LRB- ERalpha -RRB- signaling .
21700719	0	estrogen_receptor_alpha	26,49	CrkL	0,4	estrogen receptor alpha	CrkL	2099	1399	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	CrkL is a co-activator of estrogen_receptor_alpha that enhances tumorigenic potential in cancer .
18839613	0	estrogen_receptor_alpha	17,40	ER-alpha	42,50	estrogen receptor alpha	ER-alpha	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- The analysis of estrogen_receptor_alpha -LRB- ER-alpha -RRB- gene Pvull and Xbal polymorphisms in postmenopausal women with breast_cancer -RSB- .
12733715	0	estrogen_receptor_alpha	59,82	ER_alpha	84,92	estrogen receptor alpha	ER alpha	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel splicing events of untranslated first exons in human estrogen_receptor_alpha -LRB- ER_alpha -RRB- gene .
22799738	0	estrogen_receptor_alpha	15,38	ERa	40,43	estrogen receptor alpha	ERa	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of estrogen_receptor_alpha -LRB- ERa -RRB- gene polymorphisms with endometrial thickness and lipid profile in women with breast_cancer treated with aromatase inhibitors .
11507039	0	estrogen_receptor_alpha	102,125	ERalpha	160,167	estrogen receptor alpha	ERalpha	2099	2099	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Phosphatidylinositol-3-OH_Kinase -LRB- PI3K -RRB- / AKT2 , activated in breast_cancer , regulates and is induced by estrogen_receptor_alpha -LRB- ERalpha -RRB- via interaction between ERalpha and PI3K .
12627470	0	estrogen_receptor_alpha	70,93	ERalpha	95,102	estrogen receptor alpha	ERalpha	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the coding sequence and flanking splice junctions of the estrogen_receptor_alpha -LRB- ERalpha -RRB- gene does not play an important role in genetic susceptibility to bipolar_disorder or bipolar affective puerperal_psychosis .
17092701	0	estrogen_receptor_alpha	18,41	ERalpha	43,50	estrogen receptor alpha	ERalpha	2099	2099	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role of estrogen_receptor_alpha -LRB- ERalpha -RRB- phosphorylated at Serine118 in human breast_cancer in vivo .
17158758	0	estrogen_receptor_alpha	57,80	ERalpha	82,89	estrogen receptor alpha	ERalpha	2099	2099	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Endocrine therapy resistance can be associated with high estrogen_receptor_alpha -LRB- ERalpha -RRB- expression and reduced ERalpha phosphorylation in breast_cancer models .
17960587	0	estrogen_receptor_alpha	27,50	ERalpha	52,59	estrogen receptor alpha	ERalpha	2099	2099	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Differential expression of estrogen_receptor_alpha -LRB- ERalpha -RRB- protein in MCF-7 breast_cancer cells chronically exposed to TCDD .
18814026	0	estrogen_receptor_alpha	13,36	ERalpha	38,45	estrogen receptor alpha	ERalpha	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Silencing of estrogen_receptor_alpha -LRB- ERalpha -RRB- gene by promoter hypermethylation is a frequent event in Chinese women with sporadic breast_cancer .
17599809	0	estrogen_receptor_alpha	91,114	ESR1	81,85	estrogen receptor alpha	ESR1	2099	2099	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Risk for premenstrual_dysphoric_disorder is associated with genetic variation in ESR1 , the estrogen_receptor_alpha gene .
18360040	0	estrogen_receptor_alpha	38,61	ESR1	63,67	estrogen receptor alpha	ESR1	2099	2099	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotype-based case-control study of estrogen_receptor_alpha -LRB- ESR1 -RRB- gene and pregnancy-induced hypertension .
18449864	0	estrogen_receptor_alpha	25,48	ESR1	55,59	estrogen receptor alpha	ESR1	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association study of the estrogen_receptor_alpha gene -LRB- ESR1 -RRB- and childhood-onset mood_disorders .
19586561	0	estrogen_receptor_alpha	21,44	ESR1	46,50	estrogen receptor alpha	ESR1	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the estrogen_receptor_alpha -LRB- ESR1 -RRB- gene and the risk of Alzheimer 's _ disease in a southern Chinese community .
20715834	0	estrogen_receptor_alpha	80,103	ESR1	110,114	estrogen receptor alpha	ESR1	407238(Tax:9913)	407238(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen_receptor_alpha gene -LRB- ESR1 -RRB- .
20884142	0	estrogen_receptor_alpha	50,73	ESR1	80,84	estrogen receptor alpha	ESR1	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evaluation of PvuII and XbaI polymorphisms in the estrogen_receptor_alpha gene -LRB- ESR1 -RRB- in relation to menstrual cycle timing and reproductive parameters in post-menopausal women .
24756215	0	estrogen_receptor_alpha	11,34	ESR1	36,40	estrogen receptor alpha	ESR1	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Absence of estrogen_receptor_alpha -LRB- ESR1 -RRB- gene amplification in a series of breast_cancers in Taiwan .
11121195	0	estrogen_receptor_alpha	98,121	ESR_1	128,133	estrogen receptor alpha	ESR 1	2099	2099	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular genetic studies of bipolar_disorder and puerperal_psychosis at two polymorphisms in the estrogen_receptor_alpha gene -LRB- ESR_1 -RRB- .
23725356	0	estrogen_receptor_alpha	34,57	Eph_receptor_B4	0,15	estrogen receptor alpha	Eph receptor B4	2099	2050	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Eph_receptor_B4 is a regulator of estrogen_receptor_alpha in breast_cancer cells .
15367686	0	estrogen_receptor_alpha	51,74	FOXO3a	34,40	estrogen receptor alpha	FOXO3a	2099	2309	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Forkhead box transcription factor FOXO3a regulates estrogen_receptor_alpha expression and is repressed by the Her-2 / neu/phosphatidylinositol _ 3-kinase/Akt signaling pathway .
17575143	0	estrogen_receptor_alpha	84,107	FOXO3a	14,20	estrogen receptor alpha	FOXO3a	2099	2309	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of FOXO3a by the green tea polyphenol_epigallocatechin-3-gallate induces estrogen_receptor_alpha expression reversing invasive phenotype of breast_cancer cells .
19933843	0	estrogen_receptor_alpha	94,117	FoxO3a	58,64	estrogen receptor alpha	FoxO3a	2099	2309	Gene	Gene	activity|amod|START_ENTITY role|nmod|activity have|dobj|role enables|xcomp|have enables|dobj|END_ENTITY	Akt2 inhibition enables the forkhead transcription factor FoxO3a to have a repressive role in estrogen_receptor_alpha transcriptional activity in breast_cancer cells .
17616709	0	estrogen_receptor_alpha	46,69	GATA-3	36,42	estrogen receptor alpha	GATA-3	2099	2625	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Positive cross-regulatory loop ties GATA-3 to estrogen_receptor_alpha expression in breast_cancer .
17463000	0	estrogen_receptor_alpha	37,60	GREB1	14,19	estrogen receptor alpha	GREB1	2099	9687	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of GREB1 transcription by estrogen_receptor_alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences .
20023170	0	estrogen_receptor_alpha	42,65	G_protein-coupled_receptor_48	0,29	estrogen receptor alpha	G protein-coupled receptor 48	13982(Tax:10090)	107515(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	G_protein-coupled_receptor_48 upregulates estrogen_receptor_alpha expression via cAMP/PKA signaling in the male reproductive tract .
25777416	0	estrogen_receptor_alpha	33,56	HNRNP_G	0,7	estrogen receptor alpha	HNRNP G	2099	3186	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	HNRNP_G and HTRA2-BETA1 regulate estrogen_receptor_alpha expression with potential impact on endometrial_cancer .
25884434	0	estrogen_receptor_alpha	33,56	HNRNP_G	0,7	estrogen receptor alpha	HNRNP G	2099	3186	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	HNRNP_G and HTRA2-BETA1 regulate estrogen_receptor_alpha expression with potential impact on endometrial_cancer .
21421902	0	estrogen_receptor_alpha	32,55	Histone_deacetylase_6	0,21	estrogen receptor alpha	Histone deacetylase 6	2099	10013	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Histone_deacetylase_6 regulates estrogen_receptor_alpha in uterine leiomyoma .
14506618	0	estrogen_receptor_alpha	19,42	IA1	56,59	estrogen receptor alpha	IA1	2099	3642	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Genetic effects of estrogen_receptor_alpha and collagen IA1 genes on the relationships of parathyroid_hormone and 25_hydroxyvitamin_D with bone_mineral_density in Caucasian women .
14562991	0	estrogen_receptor_alpha	75,98	IA1	112,115	estrogen receptor alpha	IA1	2099	3642	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Association and linkage disequilibrium analyses suggest genetic effects of estrogen_receptor_alpha and collagen IA1 genes on bone_mineral_density in Caucasian women .
17312152	0	estrogen_receptor_alpha	104,127	IL-1alpha	25,34	estrogen receptor alpha	IL-1alpha	2099	3552	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen_receptor_alpha -LRB- ERalpha -RRB- and augmentation of transcriptional activity of Sp1 by dissociating histone_deacetylase_2 from ERalpha .
20682797	0	estrogen_receptor_alpha	47,70	JMJD2B	24,30	estrogen receptor alpha	JMJD2B	2099	23030	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The histone demethylase JMJD2B is regulated by estrogen_receptor_alpha and hypoxia , and is a key mediator of estrogen induced growth .
21680658	0	estrogen_receptor_alpha	58,81	KCNK5	38,43	estrogen receptor alpha	KCNK5	2099	8645	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	The two-pore domain potassium channel KCNK5 : induction by estrogen_receptor_alpha and role in proliferation of breast_cancer cells .
17717078	0	estrogen_receptor_alpha	66,89	Kruppel-like_factor_9	0,21	estrogen receptor alpha	Kruppel-like factor 9	2099	687	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Kruppel-like_factor_9 is a negative regulator of ligand-dependent estrogen_receptor_alpha signaling in Ishikawa endometrial_adenocarcinoma cells .
12790785	0	estrogen_receptor_alpha	70,93	LRP16	17,22	estrogen receptor alpha	LRP16	2099	28992	Gene	Gene	activation|nmod|START_ENTITY 17beta-estradiol|nmod|activation proliferation|amod|17beta-estradiol mRNA|nmod|proliferation mRNA|compound|END_ENTITY	Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen_receptor_alpha -LRB- ERalpha -RRB- , but not ERbeta , and promotion of human breast_cancer MCF-7 cell proliferation : a preliminary report .
17914104	0	estrogen_receptor_alpha	46,69	LRP16	25,30	estrogen receptor alpha	LRP16	2099	28992	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Estrogenically regulated LRP16 interacts with estrogen_receptor_alpha and enhances the receptor 's transcriptional activity .
19403568	0	estrogen_receptor_alpha	59,82	LRP16	26,31	estrogen receptor alpha	LRP16	2099	28992	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Differential induction of LRP16 by liganded and unliganded estrogen_receptor_alpha in SKOV3 ovarian_carcinoma cells .
11075819	0	estrogen_receptor_alpha	26,49	MEKK1	0,5	estrogen receptor alpha	MEKK1	2099	4214	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	MEKK1 activation of human estrogen_receptor_alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial_and_ovarian_cancer cells .
18679832	0	estrogen_receptor_alpha	15,38	MTA1	67,71	estrogen receptor alpha	MTA1	13982(Tax:10090)	116870(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Interaction of estrogen_receptor_alpha transactivation domain with MTA1 decreases in old mouse brain .
17083744	0	estrogen_receptor_alpha	114,137	MUC1	88,92	estrogen receptor alpha	MUC1	2099	4582	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	MUC1 gene overexpressed in breast_cancer : structure and transcriptional activity of the MUC1 promoter and role of estrogen_receptor_alpha -LRB- ERalpha -RRB- in regulation of the MUC1 gene expression .
24960263	0	estrogen_receptor_alpha	22,45	Med25	0,5	estrogen receptor alpha	Med25	2099	81857	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Med25 is required for estrogen_receptor_alpha -LRB- ERa -RRB- - mediated regulation of human CYP2C9 expression .
16645043	0	estrogen_receptor_alpha	50,73	Metastasis-associated_protein_2	0,31	estrogen receptor alpha	Metastasis-associated protein 2	2099	9219	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Metastasis-associated_protein_2 is a repressor of estrogen_receptor_alpha whose overexpression leads to estrogen-independent growth of human breast_cancer cells .
16226051	0	estrogen_receptor_alpha	76,99	Peroxisome_proliferator-activated_receptor_alpha	0,48	estrogen receptor alpha	Peroxisome proliferator-activated receptor alpha	2099	5465	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha expression is regulated by estrogen_receptor_alpha and modulates the response of MCF-7 cells to sodium_butyrate .
22266866	0	estrogen_receptor_alpha	17,40	RASSF1A	0,7	estrogen receptor alpha	RASSF1A	2099	11186	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	RASSF1A inhibits estrogen_receptor_alpha expression and estrogen-independent signalling : implications for breast_cancer development .
11432835	0	estrogen_receptor_alpha	30,53	Rsk2	0,4	estrogen receptor alpha	Rsk2	2099	6197	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Rsk2 allosterically activates estrogen_receptor_alpha by docking to the hormone-binding_domain .
19112174	0	estrogen_receptor_alpha	22,45	S6_kinase_1	0,11	estrogen receptor alpha	S6 kinase 1	2099	6198	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	S6_kinase_1 regulates estrogen_receptor_alpha in control of breast_cancer cell proliferation .
15831449	0	estrogen_receptor_alpha	46,69	SPBP	0,4	estrogen receptor alpha	SPBP	2099	6942	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	SPBP is a phosphoserine-specific repressor of estrogen_receptor_alpha .
15111769	0	estrogen_receptor_alpha	18,41	Sp1	62,65	estrogen receptor alpha	Sp1	2099	6667	Gene	Gene	promoter|amod|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the estrogen_receptor_alpha minimal promoter by Sp1 , USF-1_and_ERalpha .
12954762	0	estrogen_receptor_alpha	33,56	XBP-1	60,65	estrogen receptor alpha	XBP-1	2099	7494	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Ligand-independent activation of estrogen_receptor_alpha by XBP-1 .
18565642	0	estrogen_receptor_alpha	89,112	aryl_hydrocarbon_receptor_repressor	22,57	estrogen receptor alpha	aryl hydrocarbon receptor repressor	2099	57491	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Suppressive effect of aryl_hydrocarbon_receptor_repressor on transcriptional activity of estrogen_receptor_alpha by protein-protein interaction in stably and transiently expressing cell lines .
20101225	0	estrogen_receptor_alpha	16,39	c-Abl	0,5	estrogen receptor alpha	c-Abl	2099	25	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	c-Abl regulates estrogen_receptor_alpha transcription activity through its stabilization by phosphorylation .
17316976	0	estrogen_receptor_alpha	100,123	calmodulin	73,83	estrogen receptor alpha	calmodulin	2099	808	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Calmodulin-independent , agonistic properties of a peptide containing the calmodulin binding site of estrogen_receptor_alpha .
24846172	0	estrogen_receptor_alpha	76,99	claudin-5	54,63	estrogen receptor alpha	claudin-5	13982(Tax:10090)	12741(Tax:10090)	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Mechanisms of transcriptional activation of the mouse claudin-5 promoter by estrogen_receptor_alpha and beta .
19952428	0	estrogen_receptor_alpha	53,76	estrogen_receptor_alpha	80,103	estrogen receptor alpha	estrogen receptor alpha	2099	2099	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of inhibiting the proteasomal degradation of estrogen_receptor_alpha on estrogen_receptor_alpha activation under hypoxic conditions .
19952428	0	estrogen_receptor_alpha	80,103	estrogen_receptor_alpha	53,76	estrogen receptor alpha	estrogen receptor alpha	2099	2099	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of inhibiting the proteasomal degradation of estrogen_receptor_alpha on estrogen_receptor_alpha activation under hypoxic conditions .
16051668	0	estrogen_receptor_alpha	65,88	histone_deacetylase_4	15,36	estrogen receptor alpha	histone deacetylase 4	2099	9759	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of histone_deacetylase_4 to the N-terminal region of estrogen_receptor_alpha .
15318176	0	estrogen_receptor_alpha	52,75	insulin_receptor_substrate_1	8,36	estrogen receptor alpha	insulin receptor substrate 1	2099	3667	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nuclear insulin_receptor_substrate_1 interacts with estrogen_receptor_alpha at ERE promoters .
17591841	0	estrogen_receptor_alpha	4,27	insulin_receptor_substrate_1	28,56	estrogen receptor alpha	insulin receptor substrate 1	2099	3667	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	The estrogen_receptor_alpha : insulin_receptor_substrate_1 complex in breast_cancer : structure-function relationships .
12389206	0	estrogen_receptor_alpha	9,32	nitric_oxide_synthase	85,106	estrogen receptor alpha	nitric oxide synthase	13982(Tax:10090)	18125(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|regulation regulation|nmod|END_ENTITY	Roles of estrogen_receptor_alpha and androgen_receptor in the regulation of neuronal nitric_oxide_synthase .
22976807	0	estrogen_receptor_alpha	49,72	ornithine_decarboxylase	8,31	estrogen receptor alpha	ornithine decarboxylase	2099	4953	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression Role|nmod|regulation Role|nmod|END_ENTITY	Role of ornithine_decarboxylase in regulation of estrogen_receptor_alpha expression and growth in human breast_cancer cells .
17825097	0	estrogen_receptor_alpha	68,91	oxytocin	30,38	estrogen receptor alpha	oxytocin	2099	5020	Gene	Gene	expression|nmod|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	The organizational effects of oxytocin on the central expression of estrogen_receptor_alpha and oxytocin in adulthood .
15020686	0	estrogen_receptor_alpha	23,46	p130Cas	0,7	estrogen receptor alpha	p130Cas	2099	9564	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	p130Cas interacts with estrogen_receptor_alpha and modulates non-genomic estrogen signaling in breast_cancer cells .
11279135	0	estrogen_receptor_alpha	26,49	p300	66,70	estrogen receptor alpha	p300	2099	2033	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Direct acetylation of the estrogen_receptor_alpha hinge region by p300 regulates transactivation and hormone sensitivity .
14630091	0	estrogen_receptor_alpha	58,81	p33	0,3	estrogen receptor alpha	p33	2099	3621	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	p33 -LRB- ING1b -RRB- stimulates the transcriptional activity of the estrogen_receptor_alpha via its activation_function -LRB- AF -RRB- 2 domain .
17636311	0	estrogen_receptor_alpha	15,38	proliferating_cell_nuclear_antigen	44,78	estrogen receptor alpha	proliferating cell nuclear antigen	2099	5111	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of estrogen_receptor_alpha with proliferating_cell_nuclear_antigen .
14751567	0	estrogen_receptor_alpha	15,38	protein_kinase_C_alpha	44,66	estrogen receptor alpha	protein kinase C alpha	2099	5578	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of estrogen_receptor_alpha with protein_kinase_C_alpha and c-Src in osteoblasts during differentiation .
19398483	0	estrogen_receptor_alpha	109,132	vascular_endothelial_growth_factor	23,57	estrogen receptor alpha	vascular endothelial growth factor	2099	7422	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Estrogen regulation of vascular_endothelial_growth_factor in breast_cancer in vitro and in vivo : the role of estrogen_receptor_alpha and c-Myc .
25524600	0	estrogen_receptor_b	14,33	Bad	79,82	estrogen receptor b	Bad	2100	572	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Mitochondrial estrogen_receptor_b inhibits cell apoptosis via interaction with Bad in a ligand-independent manner .
25613618	0	estrogen_receptor_b	15,34	Bad	107,110	estrogen receptor b	Bad	2100	572	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Mitochondrial estrogen_receptor_b inhibits non-small_cell_lung_cancer cell apoptosis via interaction with Bad -RSB- .
22586270	0	estrogen_receptor_b	18,37	SUMO-1	43,49	estrogen receptor b	SUMO-1	2100	7341	Gene	Gene	START_ENTITY|nmod|target target|compound|END_ENTITY	Identification of estrogen_receptor_b as a SUMO-1 target reveals a novel phosphorylated sumoylation motif and regulation by glycogen_synthase_kinase_3b .
26208479	0	estrogen_receptor_beta	44,66	ERb	68,71	estrogen receptor beta	ERb	13983(Tax:10090)	13983(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Intracellular lactate-mediated induction of estrogen_receptor_beta -LRB- ERb -RRB- in biphasic malignant_pleural_mesothelioma cells .
15894829	0	estrogen_receptor_beta	63,85	ESR2	87,91	estrogen receptor beta	ESR2	13983(Tax:10090)	2100	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association study using single nucleotide polymorphisms in the estrogen_receptor_beta -LRB- ESR2 -RRB- gene for preeclampsia .
26380406	0	estrogen_related_receptor_b	31,58	ESRRB	65,70	estrogen related receptor b	ESRRB	100151940(Tax:9823)	100151940(Tax:9823)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	-LSB- Cloning and regulation of pig estrogen_related_receptor_b gene -LRB- ESRRB -RRB- promoter -RSB- .
25023176	0	estrogen_related_receptor_beta	8,38	ESRRB	40,45	estrogen related receptor beta	ESRRB	2103	2103	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of estrogen_related_receptor_beta -LRB- ESRRB -RRB- in DFN35B hearing_impairment and dental_decay .
15522178	0	estrogen_sulfotransferase	15,40	EST	42,45	estrogen sulfotransferase	EST	6783	6783	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of estrogen_sulfotransferase -LRB- EST -RRB- gene and bridging_integrator_protein-1 -LRB- BIN1 -RRB- gene and their significance in breast tissues -RSB- .
3741479	0	estrogen_synthetase	42,61	P-450	35,40	estrogen synthetase	P-450	1588	1555	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of aromatase cytochrome P-450 -LRB- estrogen_synthetase -RRB- by derivatives of alpha-naphthoflavone .
25615281	0	ethanolamine_kinase_1	29,50	ETNK1	52,57	ethanolamine kinase 1	ETNK1	55500	55500	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel recurrent mutations in ethanolamine_kinase_1 -LRB- ETNK1 -RRB- gene in systemic mastocytosis with eosinophilia and chronic_myelomonocytic_leukemia .
16127690	0	ether-a-go-go-related	26,47	ERG	49,52	ether-a-go-go-related	ERG	13876(Tax:10090)	13876(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Expression pattern of the ether-a-go-go-related -LRB- ERG -RRB- family proteins in the adult mouse central nervous system : evidence for coassembly of different subunits .
21163961	0	ethylene	36,44	XAP5_CIRCADIAN_TIMEKEEPER	0,25	ethylene	XAP5 CIRCADIAN TIMEKEEPER	821625(Tax:3702)	816650(Tax:3702)	Gene	Gene	responses|compound|START_ENTITY regulates|dobj|responses regulates|nsubj|END_ENTITY	XAP5_CIRCADIAN_TIMEKEEPER regulates ethylene responses in aerial tissues of Arabidopsis .
24114213	0	ethylene_insensitive3	49,70	EIN3	72,76	ethylene insensitive3	EIN3	101206055	101206055	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and expression analysis of the ethylene_insensitive3 -LRB- EIN3 -RRB- gene in cucumber -LRB- Cucumis_sativus -RRB- .
19236739	0	eto	20,23	aml-1	14,19	eto	aml-1	862	861	Gene	Gene	START_ENTITY|nsubj|Detection Detection|nmod|/ /|amod|END_ENTITY	-LSB- Detection of aml-1 / eto fusion gene in patients with acute_myeloid_leukemia by real-time quantitative RT-PCR -RSB- .
10891534	0	ets_gene-1	72,82	ESE-1	84,89	ets gene-1	ESE-1	1999	1999	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression analysis and mutational screening of the epithelium-specific ets_gene-1 -LRB- ESE-1 -RRB- in patients with squamous anal_cancer .
11680687	0	ets_related_gene	17,33	ERG	12,15	ets related gene	ERG	374146(Tax:9031)	374146(Tax:9031)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of ERG -LRB- ets_related_gene -RRB- in cartilage development .
18032421	0	ets_variant_gene_5	17,35	ETV5	11,15	ets variant gene 5	ETV5	104156(Tax:10090)	104156(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of ETV5 -LRB- ets_variant_gene_5 -RRB- on testis and body growth , time course of spermatogonial stem cell loss , and fertility in mice .
6283140	0	eucaryotic_initiation_factor_3	40,70	cap-binding_protein	15,34	eucaryotic initiation factor 3	cap-binding protein	8661	1977	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of cap-binding_protein with eucaryotic_initiation_factor_3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells .
26103369	0	eukaryotic_Translation_Initiation_Factor_4E	64,107	eIF4E	109,114	eukaryotic Translation Initiation Factor 4E	eIF4E	1977	1977	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	159 Stapled-peptides targeting the protein-binding interface of eukaryotic_Translation_Initiation_Factor_4E -LRB- eIF4E -RRB- protein .
25854689	0	eukaryotic_elongation_factor_1_alpha_1	17,55	EEF1A1	57,63	eukaryotic elongation factor 1 alpha 1	EEF1A1	1915	1915	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of eukaryotic_elongation_factor_1_alpha_1 -LRB- EEF1A1 -RRB- in avian_reovirus sigma-C-induced apoptosis and inhibition of viral growth .
24377563	0	eukaryotic_elongation_factor_2	18,48	eEF2	50,54	eukaryotic elongation factor 2	eEF2	1938	1938	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Clinical value of eukaryotic_elongation_factor_2 -LRB- eEF2 -RRB- in non-small cell lung_cancer patients .
24363282	0	eukaryotic_elongation_factor_2	70,100	vascular_endothelial_growth_factor	15,49	eukaryotic elongation factor 2	vascular endothelial growth factor	1938	7422	Gene	Gene	inactivation|nmod|START_ENTITY END_ENTITY|nmod|inactivation	Suppression of vascular_endothelial_growth_factor via inactivation of eukaryotic_elongation_factor_2 by alkaloids in Coptidis rhizome in hepatocellular_carcinoma .
26918606	0	eukaryotic_elongation_factor_2_kinase	30,67	FOXM1	0,5	eukaryotic elongation factor 2 kinase	FOXM1	29904	2305	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FOXM1 regulates expression of eukaryotic_elongation_factor_2_kinase and promotes proliferation , invasion and tumorgenesis of human triple negative breast_cancer cells .
11432733	0	eukaryotic_initiation_factor-2	174,204	PKR	151,154	eukaryotic initiation factor-2	PKR	8894	5610	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Mechanism of activation of the double-stranded-RNA-dependent protein kinase , PKR : role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic_initiation_factor-2 -LRB- eIF2 -RRB- .
11432733	0	eukaryotic_initiation_factor-2	174,204	PKR	77,80	eukaryotic initiation factor-2	PKR	8894	5610	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulation|nmod|phosphorylation localization|nmod|stimulation role|nmod|localization Mechanism|dep|role Mechanism|nmod|activation activation|nmod|kinase kinase|appos|END_ENTITY	Mechanism of activation of the double-stranded-RNA-dependent protein kinase , PKR : role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic_initiation_factor-2 -LRB- eIF2 -RRB- .
14558943	0	eukaryotic_initiation_factor-4E	9,40	eIF-4E	42,48	eukaryotic initiation factor-4E	eIF-4E	1977	1977	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	-LSB- Role of eukaryotic_initiation_factor-4E -LRB- eIF-4E -RRB- in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon_adenocarcinoma cell line -RSB- .
10931828	0	eukaryotic_initiation_factor_2	21,51	ABC50	0,5	eukaryotic initiation factor 2	ABC50	8894	23	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ABC50 interacts with eukaryotic_initiation_factor_2 and associates with the ribosome in an ATP-dependent manner .
17526738	0	eukaryotic_initiation_factor_2B	30,61	eIF2B	63,68	eukaryotic initiation factor 2B	eIF2B	8894	8894	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Critical contacts between the eukaryotic_initiation_factor_2B -LRB- eIF2B -RRB- catalytic domain and both eIF2beta_and _ -2 gamma mediate guanine_nucleotide exchange .
10644445	0	eukaryotic_initiation_factor_4AI	10,42	EIF4A1	49,55	eukaryotic initiation factor 4AI	EIF4A1	1973	1973	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human eukaryotic_initiation_factor_4AI gene -LRB- EIF4A1 -RRB- contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines .
24975846	0	eukaryotic_initiation_factor_4E	137,168	4E-BP1	79,85	eukaryotic initiation factor 4E	4E-BP1	1977	1978	Gene	Gene	interact|nmod|START_ENTITY potential|acl|interact discordant|nmod|potential discordant|nsubj|dynamics dynamics|nmod|protein protein|appos|END_ENTITY	Phosphorylation dynamics of eukaryotic_initiation_factor_4E binding protein 1 -LRB- 4E-BP1 -RRB- is discordant with its potential to interact with eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- .
24975846	0	eukaryotic_initiation_factor_4E	28,59	4E-BP1	79,85	eukaryotic initiation factor 4E	4E-BP1	1977	1978	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Phosphorylation dynamics of eukaryotic_initiation_factor_4E binding protein 1 -LRB- 4E-BP1 -RRB- is discordant with its potential to interact with eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- .
20537983	0	eukaryotic_initiation_factor_4E	37,68	Sox2	0,4	eukaryotic initiation factor 4E	Sox2	1977	6657	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Sox2 is translationally activated by eukaryotic_initiation_factor_4E in human glioma-initiating cells .
16431125	0	eukaryotic_initiation_factor_4E	58,89	eIF4E	91,96	eukaryotic initiation factor 4E	eIF4E	13684(Tax:10090)	13684(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Posttranscriptional regulation of TNFalpha expression via eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- phosphorylation in mouse macrophages .
20823271	0	eukaryotic_initiation_factor_4E	14,45	eIF4E	47,52	eukaryotic initiation factor 4E	eIF4E	1977	1977	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Regulation of eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- phosphorylation by mitogen-activated protein kinase occurs through modulation of Mnk1-eIF4G interaction .
9191527	0	eukaryotic_initiation_factor_4E	18,49	eIF4E	51,56	eukaryotic initiation factor 4E	eIF4E	1977	1977	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of eukaryotic_initiation_factor_4E -LRB- eIF4E -RRB- in breast_carcinoma .
16112647	0	eukaryotic_initiation_factor_4E	34,65	p53	84,87	eukaryotic initiation factor 4E	p53	1977	7157	Gene	Gene	gene|amod|START_ENTITY repression|nmod|gene repression|nmod|END_ENTITY	Transcriptional repression of the eukaryotic_initiation_factor_4E gene by wild type p53 .
11788716	0	eukaryotic_release_factor_1	30,57	eRF1	59,63	eukaryotic release factor 1	eRF1	2107	2107	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Convergence and constraint in eukaryotic_release_factor_1 -LRB- eRF1 -RRB- domain 1 : the evolution of stop codon specificity .
17443820	0	eukaryotic_translation_initiation_factor_2B	11,54	eIF2B	56,61	eukaryotic translation initiation factor 2B	eIF2B	8893	8893	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for eukaryotic_translation_initiation_factor_2B -LRB- eIF2B -RRB- in taste memory consolidation and in thermal control establishment during the critical period for sensory development .
15541024	0	eukaryotic_translation_initiation_factor_4A1	40,84	eIF4A1	86,92	eukaryotic translation initiation factor 4A1	eIF4A1	1973	1973	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	All trans-retinoic_acid -LRB- ATRA -RRB- elevated eukaryotic_translation_initiation_factor_4A1 -LRB- eIF4A1 -RRB- mRNA in ATRA-responsive vitiliginous epidermis .
21994950	0	eukaryotic_translation_initiation_factor_4B	19,62	ORF45/RSK	121,130	eukaryotic translation initiation factor 4B	ORF45/RSK	1975	4961474(Tax:37296)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4B -LRB- EIF4B -RRB- by open reading frame 45/p90 ribosomal_S6_kinase -LRB- ORF45/RSK -RRB- signaling axis facilitates protein translation during Kaposi_sarcoma-associated herpesvirus -LRB- KSHV -RRB- lytic replication .
21994950	0	eukaryotic_translation_initiation_factor_4B	19,62	ribosomal_S6_kinase	100,119	eukaryotic translation initiation factor 4B	ribosomal S6 kinase	1975	6196	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4B -LRB- EIF4B -RRB- by open reading frame 45/p90 ribosomal_S6_kinase -LRB- ORF45/RSK -RRB- signaling axis facilitates protein translation during Kaposi_sarcoma-associated herpesvirus -LRB- KSHV -RRB- lytic replication .
25197831	0	eukaryotic_translation_initiation_factor_4E	49,92	GAS5	24,28	eukaryotic translation initiation factor 4E	GAS5	1977	60674	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The long non-coding RNA GAS5 cooperates with the eukaryotic_translation_initiation_factor_4E to regulate c-Myc translation .
16107707	0	eukaryotic_translation_initiation_factor_4E	62,105	Maskin	38,44	eukaryotic translation initiation factor 4E	Maskin	734259(Tax:8355)	398145(Tax:8355)	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Differential phosphorylation controls Maskin association with eukaryotic_translation_initiation_factor_4E and localization on the mitotic apparatus .
10723135	0	eukaryotic_translation_initiation_factor_4E	41,84	cyclin_D1	94,103	eukaryotic translation initiation factor 4E	cyclin D1	117045(Tax:10116)	58919(Tax:10116)	Gene	Gene	apoptosis|nmod|START_ENTITY Inhibition|nmod|apoptosis requires|nsubj|Inhibition requires|dobj|END_ENTITY	Inhibition of Myc-dependent apoptosis by eukaryotic_translation_initiation_factor_4E requires cyclin_D1 .
16024782	0	eukaryotic_translation_initiation_factor_4E	51,94	eIF4E	96,101	eukaryotic translation initiation factor 4E	eIF4E	1977	1977	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	hnRNP_K binds a core polypyrimidine element in the eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- promoter , and its regulation of eIF4E contributes to neoplastic transformation .
16283521	0	eukaryotic_translation_initiation_factor_4E	38,81	eIF4E	83,88	eukaryotic translation initiation factor 4E	eIF4E	1977	1977	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Sodium_arsenite-induced inhibition of eukaryotic_translation_initiation_factor_4E -LRB- eIF4E -RRB- results in cytotoxicity and cell death .
22556409	0	eukaryotic_translation_initiation_factor_4E	181,224	extracellular_signal-regulated_kinase	67,104	eukaryotic translation initiation factor 4E	extracellular signal-regulated kinase	1977	5594	Gene	Gene	/|dobj|START_ENTITY END_ENTITY|acl|/	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
14673156	0	eukaryotic_translation_initiation_factor_4E	87,130	mTOR	0,4	eukaryotic translation initiation factor 4E	mTOR	1977	21977(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	mTOR controls cell cycle progression through its cell growth effectors_S6K1_and_4E-BP1 / eukaryotic_translation_initiation_factor_4E .
9032289	0	eukaryotic_translation_initiation_factor_4G	26,69	DAP-5	0,5	eukaryotic translation initiation factor 4G	DAP-5	1981	1982	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	DAP-5 , a novel homolog of eukaryotic_translation_initiation_factor_4G isolated as a putative modulator of gamma interferon-induced programmed cell death .
9878069	0	eukaryotic_translation_initiation_factor_4G	6,49	mnk1	67,71	eukaryotic translation initiation factor 4G	mnk1	1981	8569	Gene	Gene	recruits|nsubj|START_ENTITY recruits|xcomp|END_ENTITY	Human eukaryotic_translation_initiation_factor_4G -LRB- eIF4G -RRB- recruits mnk1 to phosphorylate eIF4E .
27003362	0	eukaryotic_translation_initiation_factor_4_gamma_1	19,69	EIF4G1	71,77	eukaryotic translation initiation factor 4 gamma 1	EIF4G1	1981	1981	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Functional role of eukaryotic_translation_initiation_factor_4_gamma_1 -LRB- EIF4G1 -RRB- in NSCLC .
9395514	0	eukaryotic_translation_initiation_factor_5	24,66	eIF5	68,72	eukaryotic translation initiation factor 5	eIF5	1983	1983	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Specific interaction of eukaryotic_translation_initiation_factor_5 -LRB- eIF5 -RRB- with the beta-subunit of eIF2 .
19998337	0	eukaryotic_translation_initiation_factor_5A	53,96	eIF5A	98,103	eukaryotic translation initiation factor 5A	eIF5A	1984	1984	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance and therapeutic potential of eukaryotic_translation_initiation_factor_5A -LRB- eIF5A -RRB- in hepatocellular_carcinoma .
9842718	0	eve	25,28	trol	38,42	eve	trol	36039(Tax:7227)	45320(Tax:7227)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Drosophila homeobox gene eve enhances trol , an activator of neuroblast proliferation in the larval CNS .
24257024	0	evenness_interrupted	16,36	EVI	38,41	evenness interrupted	EVI	68151(Tax:10090)	68151(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|appos|END_ENTITY	Inactivation of evenness_interrupted -LRB- EVI -RRB- reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling .
16809764	0	ever-shorter_telomeres_1B	43,68	hEST1B	70,76	ever-shorter telomeres 1B	hEST1B	23381	23381	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Histone_deacetylase_8 safeguards the human ever-shorter_telomeres_1B -LRB- hEST1B -RRB- protein from ubiquitin-mediated degradation .
21224630	0	excision_repair_complementing-1	49,80	ERCC-1	82,88	excision repair complementing-1	ERCC-1	2067	2067	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- The expression of thymidylate synthase -LRB- TS -RRB- and excision_repair_complementing-1 -LRB- ERCC-1 -RRB- protein in patients with unresectable colorectal_cancer treated with mFOLFOX6 therapy -RSB- .
21093896	0	excision_repair_cross-complementation_group_1	7,52	ERCC1	0,5	excision repair cross-complementation group 1	ERCC1	2067	2067	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	ERCC1 -LRB- excision_repair_cross-complementation_group_1 -RRB- expression as a predictor for response of neoadjuvant chemotherapy for FIGO stage 2B uterine cervix cancer .
22329847	0	excision_repair_cross-complementation_group_1	57,102	ERCC1	104,109	excision repair cross-complementation group 1	ERCC1	2067	2067	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	F-FDG uptake on PET could be a predictive marker of excision_repair_cross-complementation_group_1 -LRB- ERCC1 -RRB- expression in patients with thoracic_neoplasms ?
26179868	0	excision_repair_cross-complementation_group_1	39,84	ERCC1	86,91	excision repair cross-complementation group 1	ERCC1	2067	2067	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The prognostic and predictive value of excision_repair_cross-complementation_group_1 -LRB- ERCC1 -RRB- protein in 1288 patients with head_and_neck_squamous_cell_carcinoma treated with platinum-based therapy : a meta-analysis .
25083297	0	excision_repair_cross_complement-1	44,78	ERCC1	80,85	excision repair cross complement-1	ERCC1	2067	2067	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Breast_cancer_resistance_protein -LRB- BCRP -RRB- and excision_repair_cross_complement-1 -LRB- ERCC1 -RRB- expression in esophageal_cancers and response to cisplatin and irinotecan based chemotherapy .
14676842	0	exonuclease_1	26,39	PCNA	128,132	exonuclease 1	PCNA	9156	5111	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human exonuclease_1 in complex with mismatch repair proteins , subcellular localization and association with PCNA .
22158612	0	exostosin_Tumor-like_3	117,139	EXTL3	141,146	exostosin Tumor-like 3	EXTL3	2137	2137	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Regenerating islet-derived 1a -LRB- Reg-1a -RRB- protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin_Tumor-like_3 -LRB- EXTL3 -RRB- receptor .
26753765	0	exportin-1	44,54	XPO-1	56,61	exportin-1	XPO-1	7514	7514	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Erratum to : KPT-330 , a potent and selective exportin-1 -LRB- XPO-1 -RRB- inhibitor , shows antitumor effects modulating the expression of cyclin_D1 and survivin in prostate_cancer models .
24766216	0	exportin-1	57,67	XPO1	69,73	exportin-1	XPO1	7514	7514	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Induction of p53-mediated transcription and apoptosis by exportin-1 -LRB- XPO1 -RRB- inhibition in mantle_cell_lymphoma .
26293807	0	exportin-4	25,35	XPO4	37,41	exportin-4	XPO4	64328	64328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Copy number variation in exportin-4 -LRB- XPO4 -RRB- gene and its association with histological severity of non-alcoholic_fatty_liver_disease .
14612415	0	exportin_1	40,50	CRM1	34,38	exportin 1	CRM1	7514	7514	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	A multifunctional domain in human CRM1 -LRB- exportin_1 -RRB- mediates RanBP3 binding and multimerization of human_T-cell_leukemia_virus_type_1 Rex protein .
9658105	0	exportin_1	27,37	CRM1	21,25	exportin 1	CRM1	7514	7514	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of human CRM1 -LRB- exportin_1 -RRB- in the export and multimerization of the Rex protein of human_T-cell_leukemia_virus_type_1 .
15899157	0	extra-embryonic_tissue-spermatogenesis-homeobox_gene_1	30,84	ESX1	86,90	extra-embryonic tissue-spermatogenesis-homeobox gene 1	ESX1	13984(Tax:10090)	13984(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Stage-dependent expression of extra-embryonic_tissue-spermatogenesis-homeobox_gene_1 -LRB- ESX1 -RRB- protein , a candidate marker for X chromosome-bearing sperm .
17334602	0	extra-toes	25,35	Gli3	19,23	extra-toes	Gli3	14634(Tax:10090)	14634(Tax:10090)	Gene	Gene	region|appos|START_ENTITY region|amod|END_ENTITY	Involvement of the Gli3 -LRB- extra-toes -RRB- gene region in body weight in mice .
22496919	0	extra_domain_A	4,18	VEGF-C	44,50	extra domain A	VEGF-C	1896	7424	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	The extra_domain_A of fibronectin increases VEGF-C expression in colorectal_carcinoma involving the PI3K/AKT signaling pathway .
20554783	0	extracellular-regulated_kinase	86,116	ERK	118,121	extracellular-regulated kinase	ERK	5594	5594	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Pseudorabies_virus tegument protein Us2 recruits the mitogen-activated protein kinase extracellular-regulated_kinase -LRB- ERK -RRB- to membranes through interaction with the ERK common docking domain .
9712155	0	extracellular-regulated_kinase	99,129	ERK	131,134	extracellular-regulated kinase	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Regulation of heregulin beta1-induced differentiation in a human breast_carcinoma cell line by the extracellular-regulated_kinase -LRB- ERK -RRB- pathway .
9480836	0	extracellular-regulated_kinase	106,136	MAPKAPK5	0,8	extracellular-regulated kinase	MAPKAPK5	5594	8550	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	MAPKAPK5 , a novel mitogen-activated protein kinase -LRB- MAPK -RRB- - activated protein kinase , is a substrate of the extracellular-regulated_kinase -LRB- ERK -RRB- and p38 kinase .
9556628	0	extracellular-regulated_kinase	40,70	RHAMM	24,29	extracellular-regulated kinase	RHAMM	5594	3161	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	The hyaluronan receptor RHAMM regulates extracellular-regulated_kinase .
11299332	0	extracellular-signal-regulated_kinase	18,55	ERK	57,60	extracellular-signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of Ras extracellular-signal-regulated_kinase -LRB- ERK -RRB- mediated signaling promotes ciliary_neurotrophic_factor -LRB- CNTF -RRB- expression in Schwann cells .
12149127	0	extracellular-signal-regulated_kinase	80,117	ERK	75,78	extracellular-signal-regulated kinase	ERK	5594	5594	Gene	Gene	activation|dep|START_ENTITY activation|compound|END_ENTITY	Involvement of phospholipases D1_and_D2 in sphingosine_1-phosphate-induced ERK -LRB- extracellular-signal-regulated_kinase -RRB- activation and interleukin-8 secretion in human bronchial epithelial cells .
15757658	0	extracellular-signal-regulated_kinase	20,57	ERK	59,62	extracellular-signal-regulated kinase	ERK	5594	5594	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Tangeretin inhibits extracellular-signal-regulated_kinase -LRB- ERK -RRB- phosphorylation .
7998998	0	extracellular-signal-regulated_kinase-2	131,170	ERK-2	172,177	extracellular-signal-regulated kinase-2	ERK-2	5594	5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Protein kinase C-dependent cyclic_AMP formation in airway smooth muscle : the role of type_II_adenylate_cyclase and the blockade of extracellular-signal-regulated_kinase-2 -LRB- ERK-2 -RRB- activation .
24213635	0	extracellular-signal_regulated_kinase	83,120	Leptin	0,6	extracellular-signal regulated kinase	Leptin	5594	3952	Gene	Gene	pathway|amod|START_ENTITY promotes|nmod|pathway promotes|nsubj|END_ENTITY	Leptin promotes the proliferation and migration of human breast_cancer through the extracellular-signal_regulated_kinase pathway .
11989653	0	extracellular-signal_regulated_protein_kinase	42,87	P-glycoprotein	99,113	extracellular-signal regulated protein kinase	P-glycoprotein	26413(Tax:10090)	67078(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Reversal effect of specific inhibitors of extracellular-signal_regulated_protein_kinase pathway on P-glycoprotein mediated vincristine resistance of L1210 cells .
11514016	0	extracellular_loop	34,52	VPAC2	66,71	extracellular loop	VPAC2	6939	7434	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Proline residue 280 in the second extracellular_loop -LRB- EC2 -RRB- of the VPAC2 receptor is essential for the receptor structure .
22020146	0	extracellular_matrix_metalloproteinase_inducer	23,69	Angiotensin_II	0,14	extracellular matrix metalloproteinase inducer	Angiotensin II	12215(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces extracellular_matrix_metalloproteinase_inducer expression via an AT1R dependent pathway in aortic_atherosclerotic_plaque in apolipoprotein_E knockout mice .
22192282	0	extracellular_matrix_metalloproteinase_inducer	39,85	CD147	87,92	extracellular matrix metalloproteinase inducer	CD147	682	682	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Intracoronary upregulation of platelet extracellular_matrix_metalloproteinase_inducer -LRB- CD147 -RRB- in coronary_disease .
14985463	0	extracellular_matrix_metalloproteinase_inducer	58,104	EMMPRIN	106,113	extracellular matrix metalloproteinase inducer	EMMPRIN	682	682	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tumor-stroma interaction : positive feedback regulation of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- expression and matrix metalloproteinase-dependent generation of soluble EMMPRIN .
19639092	0	extracellular_matrix_metalloproteinase_inducer	14,60	EMMPRIN	62,69	extracellular matrix metalloproteinase inducer	EMMPRIN	682	682	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- in healthy and inflamed human gingival .
20412416	0	extracellular_matrix_metalloproteinase_inducer	44,90	EMMPRIN	92,99	extracellular matrix metalloproteinase inducer	EMMPRIN	25246(Tax:10116)	25246(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The temporal expression and localization of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- during the development of periodontitis in an animal model .
24488920	0	extracellular_matrix_metalloproteinase_inducer	14,60	EMMPRIN	62,69	extracellular matrix metalloproteinase inducer	EMMPRIN	682	682	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- in the endometrium of patients with repeated_implantation_failure after in vitro fertilization .
11929856	0	extracellular_matrix_protein_1	66,96	ECM1	103,107	extracellular matrix protein 1	ECM1	1893	1893	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lipoid_proteinosis maps to 1q21 and is caused by mutations in the extracellular_matrix_protein_1 gene -LRB- ECM1 -RRB- .
16225617	0	extracellular_matrix_protein_1	24,54	ECM1	61,65	extracellular matrix protein 1	ECM1	1893	1893	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|appos|END_ENTITY	A novel mutation of the extracellular_matrix_protein_1 gene -LRB- ECM1 -RRB- in a patient with lipoid_proteinosis -LRB- Urbach-Wiethe_disease -RRB- from Sicily .
21925250	0	extracellular_regulated_kinase	104,134	8-oxoguanine_DNA_glycosylase_1	49,79	extracellular regulated kinase	8-oxoguanine DNA glycosylase 1	5594	4968	Gene	Gene	inactivation|nmod|START_ENTITY END_ENTITY|nmod|inactivation	Silver nanoparticles down-regulate Nrf2-mediated 8-oxoguanine_DNA_glycosylase_1 through inactivation of extracellular_regulated_kinase and protein_kinase_B in human Chang liver cells .
17384257	0	extracellular_signal-regulated_kinase	23,60	Akt	61,64	extracellular signal-regulated kinase	Akt	26413(Tax:10090)	11651(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Caspase activation and extracellular_signal-regulated_kinase / Akt inhibition were involved in luteolin-induced apoptosis in Lewis_lung_carcinoma cells .
17410645	0	extracellular_signal-regulated_kinase	23,60	Akt	61,64	extracellular signal-regulated kinase	Akt	26413(Tax:10090)	11651(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Caspase activation and extracellular_signal-regulated_kinase / Akt inhibition were involved in luteolin-induced apoptosis in Lewis_lung_carcinoma cells .
18055129	0	extracellular_signal-regulated_kinase	146,183	Brain-derived_neurotrophic_factor	0,33	extracellular signal-regulated kinase	Brain-derived neurotrophic factor	24338(Tax:10116)	24225(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY autonomous|nmod|pathway autonomous|nsubj|activation activation|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of extracellular_signal-regulated_kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular_signal-regulated_kinase shutoff pathway .
18055129	0	extracellular_signal-regulated_kinase	48,85	Brain-derived_neurotrophic_factor	0,33	extracellular signal-regulated kinase	Brain-derived neurotrophic factor	24338(Tax:10116)	24225(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of extracellular_signal-regulated_kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular_signal-regulated_kinase shutoff pathway .
15367685	0	extracellular_signal-regulated_kinase	44,81	C/EBPbeta	19,28	extracellular signal-regulated kinase	C/EBPbeta	26413(Tax:10090)	12608(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of C/EBPbeta at a consensus extracellular_signal-regulated_kinase / glycogen synthase kinase 3 site is required for the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes .
9432981	0	extracellular_signal-regulated_kinase	70,107	CD40	126,130	extracellular signal-regulated kinase	CD40	5594	958	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
10749726	0	extracellular_signal-regulated_kinase	58,95	Caveolin-1	0,10	extracellular signal-regulated kinase	Caveolin-1	5594	857	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Caveolin-1 regulates shear stress-dependent activation of extracellular_signal-regulated_kinase .
20515942	0	extracellular_signal-regulated_kinase	70,107	DR5	122,125	extracellular signal-regulated kinase	DR5	5594	8795	Gene	Gene	upregulation|amod|START_ENTITY upregulation|compound|END_ENTITY	Butein sensitizes human hepatoma cells to TRAIL-induced apoptosis via extracellular_signal-regulated_kinase / Sp1-dependent DR5 upregulation and NF-kappaB inactivation .
10329108	0	extracellular_signal-regulated_kinase	54,91	ERK	93,96	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Hypertonic_saline induces prostacyclin production via extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
11181896	0	extracellular_signal-regulated_kinase	15,52	ERK	54,57	extracellular signal-regulated kinase	ERK	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of extracellular_signal-regulated_kinase -LRB- ERK -RRB- in pardaxin-induced dopamine release from PC12 cells .
11245462	0	extracellular_signal-regulated_kinase	14,51	ERK	53,56	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells .
12167697	0	extracellular_signal-regulated_kinase	29,66	ERK	68,71	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Rac-PAK signaling stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation by regulating formation of MEK1-ERK complexes .
12854829	0	extracellular_signal-regulated_kinase	19,56	ERK	58,61	extracellular signal-regulated kinase	ERK	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of osteoclast extracellular_signal-regulated_kinase -LRB- ERK -RRB- in cell survival and maintenance of cell polarity .
12855697	0	extracellular_signal-regulated_kinase	34,71	ERK	73,76	extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Ectopic B-Raf expression enhances extracellular_signal-regulated_kinase -LRB- ERK -RRB- signaling in T cells and prevents antigen-presenting cell-induced anergy .
14570609	0	extracellular_signal-regulated_kinase	11,48	ERK	50,53	extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of extracellular_signal-regulated_kinase -LRB- ERK -RRB- on focal cerebral_ischemia .
15328055	0	extracellular_signal-regulated_kinase	14,51	ERK	52,55	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation of extracellular_signal-regulated_kinase ERK after hypo-osmotic stress in renal epithelial A6 cells .
15341521	0	extracellular_signal-regulated_kinase	14,51	ERK	53,56	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Modulation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity by acute and chronic opioid treatment in neuronal and glial cell lines .
15362698	0	extracellular_signal-regulated_kinase	18,55	ERK	57,60	extracellular signal-regulated kinase	ERK	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Inhibition of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway and the induction of radioresistance in rat_3Y1 cells .
15993506	0	extracellular_signal-regulated_kinase	67,104	ERK	106,109	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	signal|amod|START_ENTITY signal|appos|END_ENTITY	Coxsackievirus B3 replication is related to activation of the late extracellular_signal-regulated_kinase -LRB- ERK -RRB- signal .
17928641	0	extracellular_signal-regulated_kinase	90,127	ERK	129,132	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effect of concomitant stimulation with cholecystokinin and epidermal growth factor on extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in pancreatic acinar cells .
18041576	0	extracellular_signal-regulated_kinase	32,69	ERK	71,74	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Drug-induced alterations in the extracellular_signal-regulated_kinase -LRB- ERK -RRB- signalling pathway : implications for reinforcement and reinstatement .
18562239	0	extracellular_signal-regulated_kinase	18,55	ERK	57,60	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	The regulation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- in mammalian cells .
19110010	0	extracellular_signal-regulated_kinase	14,51	ERK	53,56	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- signaling participates in repression of nuclear factor -LRB- NF -RRB- - kappaB activity by glucocorticoids .
19581021	0	extracellular_signal-regulated_kinase	123,160	ERK	162,165	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Vascular smooth muscle cells promote endothelial cell adhesion via microtubule dynamics and activation of paxillin and the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway in a co-culture system .
20811813	0	extracellular_signal-regulated_kinase	122,159	ERK	161,164	extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Leukocyte_common_antigen-related _ -LRB- LAR -RRB- _ tyrosine_phosphatase positively regulates osteoblast differentiation by modulating extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
21062576	0	extracellular_signal-regulated_kinase	18,55	ERK	57,60	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The alteration of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity of COS7 cells from interphase to mitosis .
21074569	0	extracellular_signal-regulated_kinase	14,51	ERK	53,56	extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity with SL327 does not prevent acquisition , expression , and extinction of ethanol-seeking behavior in mice .
21376032	0	extracellular_signal-regulated_kinase	65,102	ERK	104,107	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	An anticancer agent icaritin induces sustained activation of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway and inhibits growth of breast_cancer cells .
21454669	0	extracellular_signal-regulated_kinase	81,118	ERK	120,123	extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Wnt5a-dopamine_D2_receptor interactions regulate dopamine neuron development via extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
22884480	0	extracellular_signal-regulated_kinase	32,69	ERK	71,74	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Potential opposite roles of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway in autism spectrum and bipolar_disorders .
23782834	0	extracellular_signal-regulated_kinase	131,168	ERK	170,173	extracellular signal-regulated kinase	ERK	26413(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The Role of fibroblast_growth_factor_receptor_substrate_2 -LRB- FRS2 -RRB- in the regulation of two activity levels of the components of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- pathway in the mouse epididymis .
23935097	0	extracellular_signal-regulated_kinase	119,156	ERK	158,161	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A highly selective dual insulin_receptor -LRB- IR -RRB- / insulin-like growth factor 1 receptor -LRB- IGF-1R -RRB- inhibitor derived from an extracellular_signal-regulated_kinase -LRB- ERK -RRB- inhibitor .
24371145	0	extracellular_signal-regulated_kinase	85,122	ERK	124,127	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 -LRB- PP5 -RRB- extracellular_signal-regulated_kinase -LRB- ERK -RRB- complexes involved in the feedback regulation of Raf1 .
24653683	0	extracellular_signal-regulated_kinase	9,46	ERK	48,51	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Neuronal extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity as marker and mediator of alcohol and opioid_dependence .
24948065	0	extracellular_signal-regulated_kinase	75,112	ERK	114,117	extracellular signal-regulated kinase	ERK	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effect of active and passive intravenous cocaine administration on the extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in the rat brain .
25118288	0	extracellular_signal-regulated_kinase	99,136	ERK	138,141	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation .
26026341	0	extracellular_signal-regulated_kinase	131,168	ERK	170,173	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Thymic stromal lymphopoietin downregulates filaggrin expression by signal_transducer_and __ activator_of_transcription_3 -LRB- STAT3 -RRB- and extracellular_signal-regulated_kinase -LRB- ERK -RRB- phosphorylation in keratinocytes .
8170999	0	extracellular_signal-regulated_kinase	18,55	ERK	57,60	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	requirement|nmod|START_ENTITY requirement|appos|END_ENTITY	A requirement for extracellular_signal-regulated_kinase -LRB- ERK -RRB- function in the activation of AP-1 by Ha-Ras , phorbol_12-myristate_13-acetate , and serum .
9432981	0	extracellular_signal-regulated_kinase	70,107	ERK	109,112	extracellular signal-regulated kinase	ERK	5594	5594	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
8855340	0	extracellular_signal-regulated_kinase	106,143	Egr-1	15,20	extracellular signal-regulated kinase	Egr-1	26413(Tax:10090)	13653(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediated|nmod|activation mediated|nsubjpass|transcription transcription|compound|END_ENTITY	Urea-inducible Egr-1 transcription in renal inner medullary collecting duct -LRB- mIMCD3 -RRB- cells is mediated by extracellular_signal-regulated_kinase activation .
12791183	0	extracellular_signal-regulated_kinase	86,123	Endothelin-1	0,12	extracellular signal-regulated kinase	Endothelin-1	5594	1906	Gene	Gene	pathway|nmod|START_ENTITY promoted|nmod|pathway promoted|nsubj|END_ENTITY	Endothelin-1 promoted proliferation of vascular smooth muscle cell through pathway of extracellular_signal-regulated_kinase and cyclin_D1 .
15772344	0	extracellular_signal-regulated_kinase	38,75	Insulin-like_growth_factor_1	0,28	extracellular signal-regulated kinase	Insulin-like growth factor 1	5594	3479	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Insulin-like_growth_factor_1 inhibits extracellular_signal-regulated_kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway .
23271730	0	extracellular_signal-regulated_kinase	66,103	Interleukin-20	0,14	extracellular signal-regulated kinase	Interleukin-20	5594	50604	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Interleukin-20 promotes migration of bladder_cancer cells through extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated MMP-9 protein expression leading to nuclear factor -LRB- NF-kB -RRB- activation by inducing the up-regulation of p21 -LRB- WAF1 -RRB- protein expression .
9362525	0	extracellular_signal-regulated_kinase	58,95	JNK	131,134	extracellular signal-regulated kinase	JNK	5594	5599	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Cytotoxic_T_lymphocyte_antigen_4 -LRB- CTLA-4 -RRB- interferes with extracellular_signal-regulated_kinase -LRB- ERK -RRB- and Jun_NH2-terminal_kinase -LRB- JNK -RRB- activation , but does not affect phosphorylation of T cell receptor zeta and ZAP70 .
16075224	0	extracellular_signal-regulated_kinase	19,56	KIP1	65,69	extracellular signal-regulated kinase	KIP1	26413(Tax:10090)	12576(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of extracellular_signal-regulated_kinase and p27 -LRB- KIP1 -RRB- after retinal_detachment .
18824214	0	extracellular_signal-regulated_kinase	14,51	MKP-1	123,128	extracellular signal-regulated kinase	MKP-1	24338(Tax:10116)	114856(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of extracellular_signal-regulated_kinase -LRB- ERK -RRB- and induction of mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP-1 -RRB- by perifused thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation in rat pituitary GH3 cells .
23271730	0	extracellular_signal-regulated_kinase	66,103	MMP-9	119,124	extracellular signal-regulated kinase	MMP-9	5594	4318	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Interleukin-20 promotes migration of bladder_cancer cells through extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated MMP-9 protein expression leading to nuclear factor -LRB- NF-kB -RRB- activation by inducing the up-regulation of p21 -LRB- WAF1 -RRB- protein expression .
24975020	0	extracellular_signal-regulated_kinase	82,119	MUC5AC	71,77	extracellular signal-regulated kinase	MUC5AC	5594	4586	Gene	Gene	pathways|amod|START_ENTITY END_ENTITY|nmod|pathways	S100A8 , S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular_signal-regulated_kinase and nuclear factor-kB pathways .
24627490	0	extracellular_signal-regulated_kinase	134,171	RSK	206,209	extracellular signal-regulated kinase	RSK	5594	6196	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Complex formation between S100B protein and the p90 ribosomal S6 kinase -LRB- RSK -RRB- in malignant_melanoma is calcium-dependent and inhibits extracellular_signal-regulated_kinase -LRB- ERK -RRB- - mediated phosphorylation of RSK .
16912161	0	extracellular_signal-regulated_kinase	35,72	Ras-associated_protein-1	0,24	extracellular signal-regulated kinase	Ras-associated protein-1	5594	27342	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Ras-associated_protein-1 regulates extracellular_signal-regulated_kinase activation and migration in melanoma cells : two processes important to melanoma_tumorigenesis and metastasis .
27060290	0	extracellular_signal-regulated_kinase	68,105	Tumor_necrosis_factor-a	0,23	extracellular signal-regulated kinase	Tumor necrosis factor-a	5594	7124	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-a regulates interleukin-33 expression through extracellular_signal-regulated_kinase , p38 , and nuclear factor-kB pathways in airway epithelial cells .
14534369	0	extracellular_signal-regulated_kinase	112,149	Tumor_necrosis_factor-alpha	0,27	extracellular signal-regulated kinase	Tumor necrosis factor-alpha	5594	7124	Gene	Gene	pathways|amod|START_ENTITY END_ENTITY|nmod|pathways	Tumor_necrosis_factor-alpha and troglitazone_regulate plasminogen_activator_inhibitor_type_1 production through extracellular_signal-regulated_kinase - and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells .
9432981	0	extracellular_signal-regulated_kinase	70,107	Tumor_necrosis_factor_receptor-associated_factor_6	0,50	extracellular signal-regulated kinase	Tumor necrosis factor receptor-associated factor 6	5594	7189	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- stimulates extracellular_signal-regulated_kinase -LRB- ERK -RRB- activity in CD40 signaling along a ras-independent pathway .
9973250	0	extracellular_signal-regulated_kinase	139,176	adhesion_related_kinase	37,60	extracellular signal-regulated kinase	adhesion related kinase	26413(Tax:10090)	26362(Tax:10090)	Gene	Gene	survival|nmod|START_ENTITY promotes|dobj|survival promotes|nsubj|END_ENTITY	Growth_arrest-specific_gene_6 -LRB- Gas6 -RRB- / adhesion_related_kinase -LRB- Ark -RRB- signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular_signal-regulated_kinase -LRB- ERK -RRB- and Akt .
20074637	0	extracellular_signal-regulated_kinase	72,109	alpha-synuclein	37,52	extracellular signal-regulated kinase	alpha-synuclein	5594	6622	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Leucine-rich_repeat_kinase_2 induces alpha-synuclein expression via the extracellular_signal-regulated_kinase pathway .
12049326	0	extracellular_signal-regulated_kinase	102,139	brain-derived_neurotrophic_factor	192,225	extracellular signal-regulated kinase	brain-derived neurotrophic factor	24338(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular_signal-regulated_kinase -LRB- ERK -RRB- in the dentate gyrus : evidence for a role for brain-derived_neurotrophic_factor .
18243629	0	extracellular_signal-regulated_kinase	108,145	brain-derived_neurotrophic_factor	19,52	extracellular signal-regulated kinase	brain-derived neurotrophic factor	5594	627	Gene	Gene	activation|nmod|START_ENTITY requires|dobj|activation requires|nsubj|Neuroprotection Neuroprotection|nmod|END_ENTITY	Neuroprotection of brain-derived_neurotrophic_factor against hypoxic_injury in vitro requires activation of extracellular_signal-regulated_kinase and phosphatidylinositol_3-kinase .
12953797	0	extracellular_signal-regulated_kinase	123,160	c-jun	92,97	extracellular signal-regulated kinase	c-jun	26413(Tax:10090)	16476(Tax:10090)	Gene	Gene	expressions|nmod|START_ENTITY expressions|amod|END_ENTITY	Suppressive effect of taurine on platelet-derived growth factor -LRB- PDGF -RRB- BB-induced c-fos and c-jun mRNA expressions through extracellular_signal-regulated_kinase -LRB- ERK -RRB- in mesenchymal cell lines .
12787066	0	extracellular_signal-regulated_kinase	73,110	caveolin-1	43,53	extracellular signal-regulated kinase	caveolin-1	5594	857	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular_signal-regulated_kinase activity in B103 neuroblastoma cells : role in the pathogenesis of Parkinson 's _ disease .
10428039	0	extracellular_signal-regulated_kinase	59,96	egr-1	37,42	extracellular signal-regulated kinase	egr-1	26413(Tax:10090)	13653(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Induction of an immediate early gene egr-1 by zinc through extracellular_signal-regulated_kinase activation in cortical culture : its role in zinc-induced neuronal_death .
12695528	0	extracellular_signal-regulated_kinase	16,53	endothelin-1	138,150	extracellular signal-regulated kinase	endothelin-1	24338(Tax:10116)	24323(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY role|nmod|pathway species-mediated|nsubj|role species-mediated|dobj|expression expression|acl|induced induced|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Crucial role of extracellular_signal-regulated_kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts .
12695528	0	extracellular_signal-regulated_kinase	16,53	endothelin-1	98,110	extracellular signal-regulated kinase	endothelin-1	24338(Tax:10116)	24323(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY role|nmod|pathway species-mediated|nsubj|role species-mediated|dobj|expression expression|amod|END_ENTITY	Crucial role of extracellular_signal-regulated_kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts .
14730203	0	extracellular_signal-regulated_kinase	42,79	endothelin-1	114,126	extracellular signal-regulated kinase	endothelin-1	5594	1906	Gene	Gene	pathway|amod|START_ENTITY species-sensitive|dobj|pathway species-sensitive|nmod|expression expression|amod|END_ENTITY	Role of reactive oxygen species-sensitive extracellular_signal-regulated_kinase pathway in angiotensin_II-induced endothelin-1 gene expression in vascular endothelial cells .
14732213	0	extracellular_signal-regulated_kinase	56,93	endothelin-1	23,35	extracellular signal-regulated kinase	endothelin-1	24338(Tax:10116)	24323(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Angiotensin_II induces endothelin-1 gene expression via extracellular_signal-regulated_kinase pathway in rat aortic smooth muscle cells .
18398338	0	extracellular_signal-regulated_kinase	106,143	endothelin-1	73,85	extracellular signal-regulated kinase	endothelin-1	5594	1906	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Reactive oxygen species mediate oxidized low-density lipoprotein-induced endothelin-1 gene expression via extracellular_signal-regulated_kinase in vascular endothelial cells .
9886062	0	extracellular_signal-regulated_kinase	40,77	endothelin-1	126,138	extracellular signal-regulated kinase	endothelin-1	5594	1906	Gene	Gene	activation|amod|START_ENTITY microdomains|nmod|activation Requirement|nmod|microdomains induced|nsubj|Requirement induced|nmod|END_ENTITY	Requirement of caveolae microdomains in extracellular_signal-regulated_kinase and focal_adhesion_kinase activation induced by endothelin-1 in primary astrocytes .
22556409	0	extracellular_signal-regulated_kinase	67,104	eukaryotic_translation_initiation_factor_4E	181,224	extracellular signal-regulated kinase	eukaryotic translation initiation factor 4E	5594	1977	Gene	Gene	START_ENTITY|acl|/ /|dobj|END_ENTITY	The PP242 mammalian target of rapamycin -LRB- mTOR -RRB- inhibitor activates extracellular_signal-regulated_kinase -LRB- ERK -RRB- in multiple_myeloma cells via a target of rapamycin complex 1 -LRB- TORC1 -RRB- / eukaryotic_translation_initiation_factor_4E -LRB- eIF-4E -RRB- / RAF pathway and activation is a mechanism of resistance .
11262401	0	extracellular_signal-regulated_kinase	126,163	insulin-like_growth_factor_1	58,86	extracellular signal-regulated kinase	insulin-like growth factor 1	26413(Tax:10090)	16000(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Effects of stimulation of AMP-activated protein kinase on insulin-like_growth_factor_1 - and epidermal_growth_factor-dependent extracellular_signal-regulated_kinase pathway .
27060290	0	extracellular_signal-regulated_kinase	68,105	interleukin-33	34,48	extracellular signal-regulated kinase	interleukin-33	5594	90865	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tumor_necrosis_factor-a regulates interleukin-33 expression through extracellular_signal-regulated_kinase , p38 , and nuclear factor-kB pathways in airway epithelial cells .
14559821	0	extracellular_signal-regulated_kinase	151,188	matrix_metalloproteinase_2	116,142	extracellular signal-regulated kinase	matrix metalloproteinase 2	5594	4313	Gene	Gene	pathways|amod|START_ENTITY END_ENTITY|nmod|pathways	SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix_metalloproteinase_2 via the extracellular_signal-regulated_kinase and p38 pathways .
21453480	0	extracellular_signal-regulated_kinase	169,206	mitogen-activated_protein_kinase_kinase	123,162	extracellular signal-regulated kinase	mitogen-activated protein kinase kinase	5594	5609	Gene	Gene	ERK|dep|START_ENTITY factor|dep|ERK factor|nmod|systemic_sclerosis systemic_sclerosis|nmod|END_ENTITY	Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
22672985	0	extracellular_signal-regulated_kinase	58,95	mitogen-activated_protein_kinase_kinase	18,57	extracellular signal-regulated kinase	mitogen-activated protein kinase kinase	26413(Tax:10090)	17242(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Activation of the mitogen-activated_protein_kinase_kinase / extracellular_signal-regulated_kinase pathway overcomes cisplatin resistance in ovarian_carcinoma cells .
25774218	0	extracellular_signal-regulated_kinase	181,218	mitogen-activated_protein_kinase_kinase	135,174	extracellular signal-regulated kinase	mitogen-activated protein kinase kinase	5594	5609	Gene	Gene	ERK|dep|START_ENTITY factor|dep|ERK factor|nmod|systemic_sclerosis systemic_sclerosis|nmod|END_ENTITY	Erratum to : Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
25367151	0	extracellular_signal-regulated_kinase	193,230	p38_and_nuclear_factor-kappaB	232,261	extracellular signal-regulated kinase	p38 and nuclear factor-kappaB	5594	1432	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Down-regulating peroxisome_proliferator-activated_receptor-gamma_coactivator-1beta alleviates the proinflammatory effect of rheumatoid_arthritis fibroblast-like synoviocytes through inhibiting extracellular_signal-regulated_kinase , p38_and_nuclear_factor-kappaB activation .
17967876	0	extracellular_signal-regulated_kinase	125,162	parathyroid_hormone-related_peptide	78,113	extracellular signal-regulated kinase	parathyroid hormone-related peptide	26413(Tax:10090)	19227(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY suppresses|dobj|activation suppresses|nsubj|END_ENTITY	A-raf_and_B-raf are dispensable for normal endochondral bone development , and parathyroid_hormone-related_peptide suppresses extracellular_signal-regulated_kinase activation in hypertrophic chondrocytes .
11796505	0	extracellular_signal-regulated_kinase_1	41,80	IGF-I	102,107	extracellular signal-regulated kinase 1	IGF-I	5594	3479	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Early stimulation and late inhibition of extracellular_signal-regulated_kinase_1 / 2 phosphorylation by IGF-I : a potential mechanism mediating the switch in IGF-I action on skeletal muscle cell differentiation .
8947493	0	extracellular_signal-regulated_kinase_1	70,109	p44ERK1	54,61	extracellular signal-regulated kinase 1	p44ERK1	50689(Tax:10116)	50689(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Kinetic and biochemical correlation between sustained p44ERK1 -LRB- 44 kDa extracellular_signal-regulated_kinase_1 -RRB- activation and lysophosphatidic_acid-stimulated DNA synthesis in Rat-1 cells .
20298757	0	extracellular_signal-regulated_kinase_1_and_2	50,95	ERK1/2	97,103	extracellular signal-regulated kinase 1 and 2	ERK1/2	50689;116590	50689;116590	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression and extracellular_signal-regulated_kinase_1_and_2 -LRB- ERK1/2 -RRB- activation in exercise-reduced neuronal apoptosis after stroke .
21971976	0	extracellular_signal-regulated_kinase_1_and_2	45,90	TGF-b	17,22	extracellular signal-regulated kinase 1 and 2	TGF-b	5594	7040	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Up-regulation of TGF-b via the activation of extracellular_signal-regulated_kinase_1_and_2 induced by prorenin in human renal_mesangial_cells .
9242621	0	extracellular_signal-regulated_kinase_1_or_2	57,101	ERK1/2	103,109	extracellular signal-regulated kinase 1 or 2	ERK1/2	50689;116590	50689;116590	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Pituitary_adenylyl_cyclase-activating_peptide stimulates extracellular_signal-regulated_kinase_1_or_2 -LRB- ERK1/2 -RRB- activity in a Ras-independent , mitogen-activated protein Kinase/ERK kinase 1 or 2-dependent manner in PC12 cells .
9242621	0	extracellular_signal-regulated_kinase_1_or_2	57,101	Pituitary_adenylyl_cyclase-activating_peptide	0,45	extracellular signal-regulated kinase 1 or 2	Pituitary adenylyl cyclase-activating peptide	50689;116590	24166(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Pituitary_adenylyl_cyclase-activating_peptide stimulates extracellular_signal-regulated_kinase_1_or_2 -LRB- ERK1/2 -RRB- activity in a Ras-independent , mitogen-activated protein Kinase/ERK kinase 1 or 2-dependent manner in PC12 cells .
8246947	0	extracellular_signal-regulated_kinase_2	51,90	Epidermal_growth_factor	0,23	extracellular signal-regulated kinase 2	Epidermal growth factor	116590(Tax:10116)	25313(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces phosphorylation of extracellular_signal-regulated_kinase_2 via multiple pathways .
8006597	0	extracellular_signal-regulated_kinase_2	39,78	Raf-1	12,17	extracellular signal-regulated kinase 2	Raf-1	5594	5894	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of Raf-1 in the regulation of extracellular_signal-regulated_kinase_2 by the T_cell_antigen_receptor .
9632734	0	extracellular_signal-regulated_kinase_2	14,53	ST5	86,89	extracellular signal-regulated kinase 2	ST5	5594	6764	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Activation of extracellular_signal-regulated_kinase_2 by a novel Abl-binding protein , ST5 .
1608472	0	extracellular_signal-regulated_kinase_2	39,78	p21ras	15,21	extracellular signal-regulated kinase 2	p21ras	5594	3265	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p21ras in activation of extracellular_signal-regulated_kinase_2 .
8376929	0	extracellular_signal-regulated_kinase_2	46,85	p21ras	0,6	extracellular signal-regulated kinase 2	p21ras	5594	3265	Gene	Gene	lymphocytes|amod|START_ENTITY couples|nmod|lymphocytes couples|nsubj|END_ENTITY	p21ras couples the T_cell_antigen_receptor to extracellular_signal-regulated_kinase_2 in T lymphocytes .
11409876	0	extracellular_signal-regulated_kinase_2	8,47	p53	63,66	extracellular signal-regulated kinase 2	p53	5594	7157	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Nuclear extracellular_signal-regulated_kinase_2 phosphorylates p53 at Thr55 in response to doxorubicin .
22508986	0	extracellular_signal-regulated_kinase_3	4,43	MAPK6	81,86	extracellular signal-regulated kinase 3	MAPK6	50772(Tax:10090)	50772(Tax:10090)	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	The extracellular_signal-regulated_kinase_3 -LRB- mitogen-activated_protein_kinase_6 -LSB- MAPK6 -RSB- -RRB- - MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology .
22508986	0	extracellular_signal-regulated_kinase_3	4,43	mitogen-activated_protein_kinase_6	45,79	extracellular signal-regulated kinase 3	mitogen-activated protein kinase 6	50772(Tax:10090)	50772(Tax:10090)	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|amod|END_ENTITY	The extracellular_signal-regulated_kinase_3 -LRB- mitogen-activated_protein_kinase_6 -LSB- MAPK6 -RSB- -RRB- - MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology .
19858097	0	extracellular_signal-regulated_kinase_5	33,72	ERK5	74,78	extracellular signal-regulated kinase 5	ERK5	5598	5598	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	The signaling pathway leading to extracellular_signal-regulated_kinase_5 -LRB- ERK5 -RRB- activation via G-proteins and ERK5-dependent neurotrophic effects .
23165802	0	extracellular_signal-regulated_kinase_5	56,95	mitogen-activated_protein_kinase_1	12,46	extracellular signal-regulated kinase 5	mitogen-activated protein kinase 1	114509(Tax:10116)	116590(Tax:10116)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of big mitogen-activated_protein_kinase_1 -LRB- BMK1 -RRB- / extracellular_signal-regulated_kinase_5 -LRB- ERK5 -RRB- in the pathogenesis and progression of atherosclerosis .
10092829	0	extracellular_signal-regulated_kinases_1_and_2	39,85	ERK1/2	87,93	extracellular signal-regulated kinases 1 and 2	ERK1/2	5594	5595;5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Implication of TNF receptor-I-mediated extracellular_signal-regulated_kinases_1_and_2 -LRB- ERK1/2 -RRB- activation in growth of AIDS-associated Kaposi 's _ sarcoma cells : a possible role of a novel death domain protein MADD in TNF-alpha-induced ERK1/2 activation in Kaposi 's _ sarcoma cells .
11114188	0	extracellular_signal-regulated_kinases_1_and_2	38,84	Histone_deacetylase_4	0,21	extracellular signal-regulated kinases 1 and 2	Histone deacetylase 4	26417;26413	208727(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Histone_deacetylase_4 associates with extracellular_signal-regulated_kinases_1_and_2 , and its cellular localization is regulated by oncogenic Ras .
22988300	0	extracellular_signal-regulated_kinases_1_and_2	43,89	IkB_kinase_2	0,12	extracellular signal-regulated kinases 1 and 2	IkB kinase 2	5595	3551	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	IkB_kinase_2 regulates TPL-2 activation of extracellular_signal-regulated_kinases_1_and_2 by direct phosphorylation of TPL-2 serine 400 .
22988300	0	extracellular_signal-regulated_kinases_1_and_2	43,89	TPL-2	23,28	extracellular signal-regulated kinases 1 and 2	TPL-2	5595	1326	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	IkB_kinase_2 regulates TPL-2 activation of extracellular_signal-regulated_kinases_1_and_2 by direct phosphorylation of TPL-2 serine 400 .
12949261	0	extracellular_signal-regulated_kinases_1_and_2	93,139	angiotensin_II	64,78	extracellular signal-regulated kinases 1 and 2	angiotensin II	5594	183	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Independent beta-arrestin_2 and G protein-mediated pathways for angiotensin_II activation of extracellular_signal-regulated_kinases_1_and_2 .
16394177	0	extracellular_signal-regulated_kinases_1_and_2	87,133	bradykinin	163,173	extracellular signal-regulated kinases 1 and 2	bradykinin	5594	3827	Gene	Gene	START_ENTITY|nmod|cells cells|acl|stimulated stimulated|nmod|END_ENTITY	Protein_kinase_C _ -LRB- PKC -RRB- - delta / - epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular_signal-regulated_kinases_1_and_2 in MCF-7 cells stimulated by bradykinin .
14684627	0	extracellular_signal-regulated_kinases_1_and_2	97,143	fibroblast_growth_factor-2	56,82	extracellular signal-regulated kinases 1 and 2	fibroblast growth factor-2	5594	2247	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Heparan sulfate proteoglycans function as receptors for fibroblast_growth_factor-2 activation of extracellular_signal-regulated_kinases_1_and_2 .
11108803	0	extracellular_signal-regulated_protein_kinase	19,64	ERK	66,69	extracellular signal-regulated protein kinase	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Involvement of the extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- pathway in the induction of apoptosis by cadmium_chloride in CCRF-CEM cells .
12742123	0	extracellular_signal-regulated_protein_kinase	145,190	ERK	192,195	extracellular signal-regulated protein kinase	ERK	5594	5594	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Application of multiplexed capillary electrophoresis with laser-induced fluorescence -LRB- MCE-LIF -RRB- detection for the rapid measurement of endogenous extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- levels in cell extracts .
16865246	0	extracellular_signal-regulated_protein_kinase	23,68	ERK	70,73	extracellular signal-regulated protein kinase	ERK	5594	5594	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Selective reduction of extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- phosphorylation in squamous_cell_carcinoma of the larynx .
19167979	0	extracellular_signal-regulated_protein_kinase	8,53	ERK	55,58	extracellular signal-regulated protein kinase	ERK	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of extracellular_signal-regulated_protein_kinase -LRB- ERK -RRB- in 17beta-estradiol-mediated attenuation of lung_injury after trauma-hemorrhage .
9933031	0	extracellular_signal-regulated_protein_kinase	57,102	Epidermal_growth_factor	0,23	extracellular signal-regulated protein kinase	Epidermal growth factor	24338(Tax:10116)	25313(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Epidermal_growth_factor and angiotensin_II regulation of extracellular_signal-regulated_protein_kinase in rat liver epithelial WB cells .
19538337	0	extracellular_signal-regulated_protein_kinase	71,116	P21	117,120	extracellular signal-regulated protein kinase	P21	5594	1026	Gene	Gene	pathways|amod|START_ENTITY pathways|dep|END_ENTITY	Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular_signal-regulated_protein_kinase / P21 -LRB- CIP1 -RRB- / P27 -LRB- KIP1 -RRB- pathways .
15196791	0	extracellular_signal-regulated_protein_kinase	152,197	c-fos	121,126	extracellular signal-regulated protein kinase	c-fos	26413(Tax:10090)	14281(Tax:10090)	Gene	Gene	linked|nmod|START_ENTITY expression|acl|linked expression|amod|END_ENTITY	A neuroactive steroid , dehydroepiandrosterone_sulfate , prevents the development of morphine_dependence and tolerance via c-fos expression linked to the extracellular_signal-regulated_protein_kinase .
18479823	0	extracellular_signal-regulated_protein_kinase	15,60	c-fos	86,91	extracellular signal-regulated protein kinase	c-fos	5594	2353	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of extracellular_signal-regulated_protein_kinase in acute cocaine-induced c-fos in nucleus accumbens .
16270297	0	extracellular_signal-regulated_protein_kinase	12,57	carbonic_anhydrase_IX	110,131	extracellular signal-regulated protein kinase	carbonic anhydrase IX	5594	768	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of extracellular_signal-regulated_protein_kinase in transcriptional regulation of the hypoxia marker carbonic_anhydrase_IX .
15452854	0	extracellular_signal-related_kinase	35,70	ERK	72,75	extracellular signal-related kinase	ERK	5594	5594	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Experience-dependent activation of extracellular_signal-related_kinase -LRB- ERK -RRB- in the olfactory bulb .
10528214	0	extracellular_signal-related_kinase	14,49	c-Jun_N-terminal_kinase	68,91	extracellular signal-related kinase	c-Jun N-terminal kinase	5594	5599	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	Src-regulated extracellular_signal-related_kinase and Syk-regulated c-Jun_N-terminal_kinase pathways act in conjunction to induce IL-1 synthesis in response to microtubule disruption in HL60 cells .
12151316	0	extracellular_signal-related_kinase	114,149	interleukin-8	32,45	extracellular signal-related kinase	interleukin-8	5594	3576	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular_signal-related_kinase and c-Jun_N-terminal_kinase activation .
10929041	0	extracellular_signal-related_kinase_2	151,188	thrombin	120,128	extracellular signal-related kinase 2	thrombin	5594	2147	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Porcine von_Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase -LRB- JNK/SAPK -RRB- whereas only thrombin induces activation of extracellular_signal-related_kinase_2 -LRB- ERK2 -RRB- in human platelets .
12160213	0	extracellular_signal_regulated_kinase	31,68	ERK	70,73	extracellular signal regulated kinase	ERK	24338(Tax:10116)	24338(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Midkine inhibits apoptosis via extracellular_signal_regulated_kinase -LRB- ERK -RRB- activation in PC12 cells .
16254105	0	extracellular_signal_regulated_kinase	18,55	ERK	57,60	extracellular signal regulated kinase	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Activation of the extracellular_signal_regulated_kinase -LRB- ERK -RRB- pathway in human melanoma .
11564869	0	extracellular_stimulus-regulated_kinase	54,93	Hematopoietic_protein_tyrosine_phosphatase	0,42	extracellular stimulus-regulated kinase	Hematopoietic protein tyrosine phosphatase	26413(Tax:10090)	320139(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY suppresses|dobj|activation suppresses|nsubj|END_ENTITY	Hematopoietic_protein_tyrosine_phosphatase suppresses extracellular_stimulus-regulated_kinase activation .
9290261	0	extracellular_superoxide_dismutase	16,50	EC-SOD	52,58	extracellular superoxide dismutase	EC-SOD	6649	6649	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of extracellular_superoxide_dismutase -LRB- EC-SOD -RRB- gene : relation to the mutation responsible for high EC-SOD level in serum .
25264884	0	extracellular_superoxide_dismutase	38,72	aldehyde_dehydrogenase-2	74,98	extracellular superoxide dismutase	aldehyde dehydrogenase-2	6649	217	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Correlations between polymorphisms of extracellular_superoxide_dismutase , aldehyde_dehydrogenase-2 genes , as well as drinking behavior and pancreatic_cancer .
8090202	0	extraembryonic_development	28,54	Mash-2	18,24	extraembryonic development	Mash-2	70790(Tax:10090)	17173(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Essential role of Mash-2 in extraembryonic_development .
11770002	0	extraneuronal_monoamine_transporter	20,55	hEMT	57,61	extraneuronal monoamine transporter	hEMT	6581	3702	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of human extraneuronal_monoamine_transporter -LRB- hEMT -RRB- expressed in HEK293 cells by intracellular second messenger systems .
2571575	0	eye_lens_obsolescence	46,67	Elo	69,72	eye lens obsolescence	Elo	12968(Tax:10090)	12968(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Linkage analysis of the mutation locus in the eye_lens_obsolescence -LRB- Elo -RRB- mouse .
22553461	0	eyes_absent	11,22	DTIS11	83,89	eyes absent	DTIS11	33916(Tax:7227)	32222(Tax:7227)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Drosophila eyes_absent is a novel mRNA target of the tristetraprolin -LRB- TTP -RRB- protein DTIS11 .
19896935	0	eyg	12,15	Pax	16,19	eyg	Pax	39419(Tax:7227)	35215(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The role of eyg Pax gene in the development of the head vertex in Drosophila .
24398676	0	ezrin	39,44	AKT	0,3	ezrin	AKT	7430	207	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex : role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking .
12032545	0	ezrin	46,51	CD44	41,45	ezrin	CD44	7430	960	Gene	Gene	association|compound|START_ENTITY association|compound|END_ENTITY	A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility .
15064738	0	ezrin	55,60	Dbl	88,91	ezrin	Dbl	7430	4168	Gene	Gene	association|compound|START_ENTITY association|nmod|END_ENTITY	Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo .
8360275	0	ezrin	13,18	Moesin	0,6	ezrin	Moesin	7430	4478	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	Moesin , like ezrin , colocalizes with actin in the cortical cytoskeleton in cultured cells , but its expression is more variable .
9928947	0	ezrin	73,78	Moesin	0,6	ezrin	Moesin	7430	4478	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Moesin , the major ERM protein of lymphocytes and platelets , differs from ezrin in its insensitivity to calpain .
17270023	0	ezrin	18,23	NGX6	56,60	ezrin	NGX6	7430	51754	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of ezrin in NPC and its interaction with NGX6 , a novel candidate suppressor .
21780101	0	ezrin	24,29	P-glycoprotein	0,14	ezrin	P-glycoprotein	7430	5243	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	P-glycoprotein binds to ezrin at amino_acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma .
15623525	0	ezrin	19,24	Src	0,3	ezrin	Src	7430	6714	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Src phosphorylates ezrin at tyrosine 477 and induces a phosphospecific association between ezrin and a kelch-repeat protein family member .
17453948	0	ezrin	48,53	epidermal_growth_factor_receptor	14,46	ezrin	epidermal growth factor receptor	7430	1956	Gene	Gene	factor|dep|START_ENTITY factor|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor , ezrin , hepatocyte growth factor , and c-Met in uveal_melanoma : an immunohistochemical study .
24629131	0	ezrin	27,32	ezrin	52,57	ezrin	ezrin	7430	7430	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prognostic implications of ezrin and phosphorylated ezrin expression in non-small_cell_lung_cancer .
24629131	0	ezrin	52,57	ezrin	27,32	ezrin	ezrin	7430	7430	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prognostic implications of ezrin and phosphorylated ezrin expression in non-small_cell_lung_cancer .
16231158	0	ezrin	47,52	moesin	65,71	ezrin	moesin	7430	4478	Gene	Gene	analysis|nmod|START_ENTITY analysis|acl|END_ENTITY	Mutational and immunohistochemical analysis of ezrin - , radixin - , moesin -LRB- ERM -RRB- molecules in epilepsy-associated glioneuronal_lesions .
18025306	0	ezrin	56,61	moesin	82,88	ezrin	moesin	7430	4478	Gene	Gene	removal|compound|START_ENTITY requires|nmod|removal requires|nmod|END_ENTITY	Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin .
20109539	0	ezrin	14,19	moesin	28,34	ezrin	moesin	7430	4478	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream .
22412054	0	ezrin	67,72	podocalyxin	36,47	ezrin	podocalyxin	7430	5420	Gene	Gene	START_ENTITY|nsubj|significance significance|nmod|END_ENTITY	Clinicopathological significance of podocalyxin and phosphorylated ezrin in uterine endometrioid_adenocarcinoma .
20109539	0	ezrin	14,19	radixin	20,27	ezrin	radixin	7430	5962	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream .
22012890	0	ezrin	27,32	radixin	34,41	ezrin	radixin	7430	5962	Gene	Gene	domain|dep|START_ENTITY domain|dep|END_ENTITY	Unfurling of the band_4 .1 , ezrin , radixin , moesin -LRB- FERM -RRB- domain of the merlin tumor suppressor .
2141826	0	f-Met-Leu-Phe	31,44	FMLP	46,50	f-Met-Leu-Phe	FMLP	2357	2357	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of chemotactic peptide f-Met-Leu-Phe -LRB- FMLP -RRB- on C3b_receptor -LRB- CR1 -RRB- expression and phagocytosis of microspheres by human neutrophils .
10781834	0	fH	92,94	fHR-1	96,101	fH	fHR-1	3075	3078	Gene	Gene	START_ENTITY|appos|genes genes|amod|END_ENTITY	Complement factor_H : sequence analysis of 221 kb of human genomic DNA containing the entire fH , fHR-1 and fHR-3 genes .
10781834	0	fHR-1	96,101	fH	92,94	fHR-1	fH	3078	3075	Gene	Gene	genes|amod|START_ENTITY END_ENTITY|appos|genes	Complement factor_H : sequence analysis of 221 kb of human genomic DNA containing the entire fH , fHR-1 and fHR-3 genes .
17185631	0	fMLP	0,4	Hsp27	13,18	fMLP	Hsp27	2357	3315	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	fMLP induces Hsp27 expression , attenuates NF-kappaB activation , and confers intestinal epithelial cell protection .
1740648	0	fMLP	110,114	NAP-1	129,134	fMLP	NAP-1	2357	3576	Gene	Gene	mobilization|nmod|START_ENTITY END_ENTITY|nmod|mobilization	Heterogeneity in the mobilization of cytoplasmic calcium by human polymorphonuclear leukocytes in response to fMLP , C5a and IL-8 / NAP-1 .
10419502	0	fMet-Leu-Phe	13,25	Ral	83,86	fMet-Leu-Phe	Ral	2357	5898	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Differential fMet-Leu-Phe - and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils .
10458911	0	faciogenital_dysplasia	76,98	FGD1	100,104	faciogenital dysplasia	FGD1	2245	2245	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation , characterization , and mapping of the mouse and human Fgd2 genes , faciogenital_dysplasia -LRB- FGD1 ; Aarskog_syndrome -RRB- gene homologues .
9268645	0	faciogenital_dysplasia	28,50	FGD1	52,56	faciogenital dysplasia	FGD1	2245	2245	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the faciogenital_dysplasia -LRB- FGD1 ; Aarskog_syndrome -RRB- gene .
19110080	0	faciogenital_dysplasia_1	30,54	FGD1	56,60	faciogenital dysplasia 1	FGD1	2245	2245	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	First case of deletion of the faciogenital_dysplasia_1 -LRB- FGD1 -RRB- gene in a patient with Aarskog-Scott_syndrome .
1408750	0	factor_2	57,65	Adf-2	67,72	factor 2	Adf-2	45894(Tax:7227)	2768981(Tax:7227)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization and purification of Adh distal promoter factor_2 , Adf-2 , a cell-specific and promoter-specific repressor in Drosophila .
10490997	0	factor_H	107,115	C-reactive_protein	39,57	factor H	C-reactive protein	3075	1401	Gene	Gene	activity|nmod|START_ENTITY targeting|dobj|activity complement|dep|targeting complement|nmod|END_ENTITY	Regulation of complement activation by C-reactive_protein : targeting the complement inhibitory activity of factor_H by an interaction with short consensus repeat domains 7 and 8-11 .
17339482	0	factor_H	33,41	C-reactive_protein	70,88	factor H	C-reactive protein	3075	1401	Gene	Gene	polymorphism|nmod|START_ENTITY affects|nsubj|polymorphism affects|nmod|END_ENTITY	Y402H polymorphism of complement factor_H affects binding affinity to C-reactive_protein .
19850925	0	factor_H	11,19	C-reactive_protein	54,72	factor H	C-reactive protein	3075	1401	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Complement factor_H binds at two independent sites to C-reactive_protein in acute phase concentrations .
21317894	0	factor_H	46,54	C3b	58,61	factor H	C3b	3075	718	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for engagement by complement factor_H of C3b on a self surface .
21285368	0	factor_H	20,28	C3d	34,37	factor H	C3d	3075	100861467	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Dual interaction of factor_H with C3d and glycosaminoglycans in host-nonhost discrimination by complement .
12402151	0	factor_H	43,51	FHL-1	79,84	factor H	FHL-1	3075	2273	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Secretion of soluble complement inhibitors factor_H and factor_H-like protein -LRB- FHL-1 -RRB- by ovarian_tumour cells .
11292770	0	factor_H	50,58	PspC	0,4	factor H	PspC	3075	6440	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	PspC , a pneumococcal surface protein , binds human factor_H .
12228288	0	factor_H	31,39	PspC	75,79	factor H	PspC	3075	6440	Gene	Gene	binds|nsubj|START_ENTITY binds|ccomp|repeats repeats|nsubj|END_ENTITY	The human complement regulator factor_H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15 .
15232165	0	factor_H	21,29	PspC	35,39	factor H	PspC	3075	6440	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human factor_H with PspC of Streptococcus_pneumoniae .
26468283	0	factor_H	11,19	apolipoprotein_E	41,57	factor H	apolipoprotein E	3075	348	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Complement factor_H binds to human serum apolipoprotein_E and mediates complement regulation on high-density lipoprotein particles .
25185576	0	factor_H	43,51	factor_H	77,85	factor H	factor H	3075	3075	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Heterogeneity in rhesus_macaque complement factor_H binding to meningococcal factor_H binding protein -LRB- FHbp -RRB- informs selection of primates to assess immunogenicity of FHbp-based vaccines .
25185576	0	factor_H	77,85	factor_H	43,51	factor H	factor H	3075	3075	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Heterogeneity in rhesus_macaque complement factor_H binding to meningococcal factor_H binding protein -LRB- FHbp -RRB- informs selection of primates to assess immunogenicity of FHbp-based vaccines .
18605956	0	factor_VII-activating_protease	29,59	FSAP	61,65	factor VII-activating protease	FSAP	3026	3026	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Tests for the measurement of factor_VII-activating_protease -LRB- FSAP -RRB- activity and antigen levels in citrated plasma , their correlation to PCR testing , and utility for the detection of the Marburg I-polymorphism of FSAP .
18753248	0	factor_VII-activating_protease	44,74	Nucleosome-releasing_factor	0,27	factor VII-activating protease	Nucleosome-releasing factor	3026	55922	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Nucleosome-releasing_factor : a new role for factor_VII-activating_protease -LRB- FSAP -RRB- .
17540775	0	factor_VII-activating_protease	53,83	Plasminogen_activator_inhibitor-1	0,33	factor VII-activating protease	Plasminogen activator inhibitor-1	3026	5054	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Plasminogen_activator_inhibitor-1 is an inhibitor of factor_VII-activating_protease in patients with acute_respiratory_distress_syndrome .
23341458	0	factor_VII-activating_protease	4,34	bone_morphogenetic_protein-2	67,95	factor VII-activating protease	bone morphogenetic protein-2	3026	650	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|nmod|END_ENTITY	The factor_VII-activating_protease -LRB- FSAP -RRB- enhances the activity of bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- .
11748850	0	factor_VIII	54,65	F8C	67,70	factor VIII	F8C	2157	2157	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Seven novel and four recurrent point mutations in the factor_VIII -LRB- F8C -RRB- gene .
11754115	0	factor_VIII	54,65	F8C	67,70	factor VIII	F8C	2157	2157	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Seven novel and four recurrent point mutations in the factor_VIII -LRB- F8C -RRB- gene .
9760209	0	factor_VIII	55,66	F8C	68,71	factor VIII	F8C	2157	2157	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation of site-specific methylation patterns in the factor_VIII -LRB- F8C -RRB- gene in human sperm DNA .
15213843	0	factor_VIII	5,16	FVIII	18,23	factor VIII	FVIII	2157	2157	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	High factor_VIII -LRB- FVIII -RRB- levels in venous_thromboembolism : role of unbound FVIII .
16643210	0	factor_VIII	71,82	FVIII	93,98	factor VIII	FVIII	2157	2157	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	A modified chromogenic assay for the measurement of very low levels of factor_VIII activity -LRB- FVIII : C -RRB- .
11187883	0	factor_VIII	54,65	Factor_VIII	0,11	factor VIII	Factor VIII	2157	2157	Gene	Gene	activity|nmod|START_ENTITY inhibitor|nmod|activity inhibitor|nsubj|END_ENTITY	Factor_VIII inhibitor with catalytic activity towards factor_VIII .
21699629	0	factor_VIII	49,60	VWF	105,108	factor VIII	VWF	2157	7450	Gene	Gene	Optivate|appos|START_ENTITY experience|nmod|Optivate experience|appos|END_ENTITY	Clinical experience with Optivate , high-purity factor_VIII -LRB- FVIII -RRB- product with von_Willebrand factor -LRB- VWF -RRB- in young children with haemophilia_A .
12195693	0	factor_VIII	32,43	Von_Willebrand_factor	0,21	factor VIII	Von Willebrand factor	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Von_Willebrand_factor modulates factor_VIII immunogenicity : comparative study of different factor_VIII concentrates in a haemophilia_A mouse model .
12195693	0	factor_VIII	91,102	Von_Willebrand_factor	0,21	factor VIII	Von Willebrand factor	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	study|nmod|START_ENTITY concentrates|nsubj|study modulates|parataxis|concentrates modulates|nsubj|END_ENTITY	Von_Willebrand_factor modulates factor_VIII immunogenicity : comparative study of different factor_VIII concentrates in a haemophilia_A mouse model .
19786936	0	factor_VIII	22,33	Von_Willebrand_factor	0,21	factor VIII	Von Willebrand factor	2157	7450	Gene	Gene	concentrates|nsubj|START_ENTITY END_ENTITY|parataxis|concentrates	Von_Willebrand_factor / factor_VIII concentrates in the treatment of von_Willebrand disease .
10521497	0	factor_VIII	33,44	factor_VIII	8,19	factor VIII	factor VIII	2157	2157	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Role of factor_VIII C2 domain in factor_VIII binding to factor_Xa .
10521497	0	factor_VIII	8,19	factor_VIII	33,44	factor VIII	factor VIII	2157	2157	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Role of factor_VIII C2 domain in factor_VIII binding to factor_Xa .
16824190	0	factor_VIII	41,52	factor_VIII	91,102	factor VIII	factor VIII	14069(Tax:10090)	14069(Tax:10090)	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Induction of partial immune tolerance to factor_VIII through prior mucosal exposure to the factor_VIII C2 domain .
16824190	0	factor_VIII	91,102	factor_VIII	41,52	factor VIII	factor VIII	14069(Tax:10090)	14069(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Induction of partial immune tolerance to factor_VIII through prior mucosal exposure to the factor_VIII C2 domain .
12689655	0	factor_VIII	32,43	interleukin-1	48,61	factor VIII	interleukin-1	2157	3552	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	An antibody to VEGF upregulates factor_VIII via interleukin-1 in activated adrenal cortex-derived capillary endothelial cells .
17376515	0	factor_VIII	103,114	von_Willebrand_factor	0,21	factor VIII	von Willebrand factor	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	modulate|nmod|START_ENTITY modulate|nsubj|END_ENTITY	von_Willebrand_factor and transforming growth factor-beta modulate immune response against coagulation factor_VIII in FVIII-deficient mice .
2104761	0	factor_VIII	59,70	von_Willebrand_factor	6,27	factor VIII	von Willebrand factor	2157	7450	Gene	Gene	patient|nmod|START_ENTITY deficiency|amod|patient defect|nmod|deficiency _|dobj|defect _|nsubj|_ _|compound|END_ENTITY	A new von_Willebrand_factor _ -LRB- vWF -RRB- _ defect in a patient with factor_VIII -LRB- FVIII -RRB- deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF .
22044692	0	factor_VIII	69,80	von_Willebrand_factor	27,48	factor VIII	von Willebrand factor	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Immunoprotective effect of von_Willebrand_factor towards therapeutic factor_VIII in experimental haemophilia_A .
24850761	0	factor_VIII	100,111	von_Willebrand_factor	2,23	factor VIII	von Willebrand factor	14069(Tax:10090)	22371(Tax:10090)	Gene	Gene	stabilize|dobj|START_ENTITY sufficient|xcomp|stabilize sufficient|nsubj|fragment fragment|compound|END_ENTITY	A von_Willebrand_factor fragment containing the D'D3 domains is sufficient to stabilize coagulation factor_VIII in mice .
22878700	0	factor_VII_activating_protease	23,53	FSAP	55,59	factor VII activating protease	FSAP	3026	3026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nicotine modulation of factor_VII_activating_protease -LRB- FSAP -RRB- expression in human monocytes .
8698336	0	factor_V_Leiden	54,69	coagulation_factor_V	27,47	factor V Leiden	coagulation factor V	2153	2153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The G1691A mutation of the coagulation_factor_V gene -LRB- factor_V_Leiden -RRB- is rare in Chinese : an analysis of 618 individuals .
17290027	0	factor_V_Leiden	4,19	prothrombin	21,32	factor V Leiden	prothrombin	2153	2147	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	The factor_V_Leiden , prothrombin gene 20210GA , methylenetetrahydrofolate_reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic_stroke and atrial_fibrillation .
25623511	0	factor_XI	40,49	FXI	51,54	factor XI	FXI	2160	2160	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Bleeding phenotype and correlation with factor_XI -LRB- FXI -RRB- activity in congenital_FXI_deficiency : results of a retrospective study from a single centre .
12968031	0	factor_XI	23,32	Thrombin	0,8	factor XI	Thrombin	2160	2147	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Thrombin activation of factor_XI on activated platelets requires the interaction of factor_XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II , respectively .
15317813	0	factor_XI	83,92	glycoprotein_Ibalpha	37,57	factor XI	glycoprotein Ibalpha	2160	2811	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|site site|nmod|END_ENTITY	Identification of a binding site for glycoprotein_Ibalpha in the Apple 3 domain of factor_XI .
8631976	0	factor_XI	53,62	thrombin	19,27	factor XI	thrombin	2160	2147	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	A binding site for thrombin in the apple 1 domain of factor_XI .
2019789	0	factor_XII	23,33	Hageman_factor	35,49	factor XII	Hageman factor	306761(Tax:10116)	306761(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of factor_XII -LRB- Hageman_factor -RRB- in isolated livers of estrogen - and prolactin-treated rats .
12373334	0	factor_XIIIa	118,130	CD1a	111,115	factor XIIIa	CD1a	2162	909	Gene	Gene	+|compound|START_ENTITY +|appos|+ +|compound|END_ENTITY	Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses : CD1a + , factor_XIIIa + , and CD68 + cells in eczematous_dermatitis , psoriasis , lichen_planus_and_graft-versus-host_disease .
2877688	0	factor_XIIIa	52,64	Thrombospondin	0,14	factor XIIIa	Thrombospondin	2162	7057	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Thrombospondin is a substrate for blood_coagulation factor_XIIIa .
11287128	0	factor_Xa	72,81	Antithrombin	0,12	factor Xa	Antithrombin	2159	462	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Antithrombin binding of low molecular weight heparins and inhibition of factor_Xa .
20702967	0	factor_Xa	18,27	FXa	29,32	factor Xa	FXa	2159	2159	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	-LSB- Do orally active factor_Xa -LRB- FXa -RRB- inhibitors have potential as innovative new anticoagulants ?
14575696	0	factor_Xa	84,93	Platelet_factor_4	0,17	factor Xa	Platelet factor 4	2159	5196	Gene	Gene	inactivation|nmod|START_ENTITY neutralizes|dobj|inactivation neutralizes|nsubj|END_ENTITY	Platelet_factor_4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor_Xa by preventing interaction -LRB- s -RRB- of enzyme with polysaccharide .
10627484	0	factor_Xa	63,72	Prothrombin	0,11	factor Xa	Prothrombin	2159	2147	Gene	Gene	results|amod|START_ENTITY substitution|nmod|results Antonio|dep|substitution Antonio|compound|END_ENTITY	Prothrombin San Antonio : a single amino_acid substitution at a factor_Xa activation site -LRB- Arg320_to_His -RRB- results in dysprothrombinemia .
11290592	0	factor_Xa	21,30	Prothrombin	0,11	factor Xa	Prothrombin	2159	2147	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Prothrombin protects factor_Xa in the prothrombinase complex from inhibition by the heparin-antithrombin complex .
3787558	0	factor_Xa	80,89	Prothrombin	0,11	factor Xa	Prothrombin	2159	2147	Gene	Gene	variant|nmod|START_ENTITY Clamart|dep|variant Clamart|compound|END_ENTITY	Prothrombin Clamart : prothrombin variant with defective Arg 320-IIe cleavage by factor_Xa .
6580622	0	factor_Xa	58,67	Prothrombin	0,11	factor Xa	Prothrombin	2159	2147	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Prothrombin is activated on vascular endothelial cells by factor_Xa and calcium .
21566199	0	factor_Xa	123,132	R1663	108,113	factor Xa	R1663	2159	174621(Tax:6239)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Crossover dose escalation study to assess safety , pharmacokinetics , and pharmacodynamics of single doses of R1663 , an oral factor_Xa inhibitor , in healthy male volunteers .
22552265	0	factor_Xa	92,101	R1663	77,82	factor Xa	R1663	2159	174621(Tax:6239)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Safety , pharmacokinetics and pharmacodynamics of multiple ascending doses of R1663 , an oral factor_Xa inhibitor , in healthy young subjects coupled with exploration of influence of gender and age .
2445377	0	factor_Xa	38,47	alpha_2-macroglobulin	51,72	factor Xa	alpha 2-macroglobulin	2159	2	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human blood_coagulation factor_Xa by alpha_2-macroglobulin .
10660568	0	factor_Xa	82,91	antithrombin	50,62	factor Xa	antithrombin	2159	462	Gene	Gene	inhibitor|nmod|START_ENTITY activates|nmod|inhibitor activates|dobj|END_ENTITY	Serine 380 -LRB- P14 -RRB- _ -- > _ glutamate mutation activates antithrombin as an inhibitor of factor_Xa .
11278930	1	factor_Xa	165,174	antithrombin	208,220	factor Xa	antithrombin	2159	462	Gene	Gene	specificity|compound|START_ENTITY determinant|nmod|specificity Evidence|nmod|determinant Evidence|nmod|END_ENTITY	Evidence for an exosite determinant of factor_Xa specificity in heparin-activated antithrombin .
11380263	0	factor_Xa	175,184	antithrombin	58,70	factor Xa	antithrombin	2159	462	Gene	Gene	inhibition|compound|START_ENTITY mechanism|nmod|inhibition consequences|nmod|mechanism state|dep|consequences examined|nmod|state examined|nsubj|equilibrium equilibrium|nmod|loop loop|nmod|END_ENTITY	Conformational equilibrium of the reactive center loop of antithrombin examined by steady state and time-resolved fluorescence measurements : consequences for the mechanism of factor_Xa inhibition by antithrombin-heparin complexes .
11687304	0	factor_Xa	31,40	antithrombin	83,95	factor Xa	antithrombin	2159	462	Gene	Gene	specificity|compound|START_ENTITY basis|nmod|specificity Probing|dobj|basis Probing|nmod|mutagenesis mutagenesis|nmod|serpin serpin|appos|END_ENTITY	Probing the molecular basis of factor_Xa specificity by mutagenesis of the serpin , antithrombin .
12695507	0	factor_Xa	58,67	antithrombin	83,95	factor Xa	antithrombin	2159	462	Gene	Gene	inhibition|nmod|START_ENTITY catalysis|nmod|inhibition responsible|nmod|catalysis Mechanisms|xcomp|responsible Mechanisms|nmod|END_ENTITY	Mechanisms responsible for catalysis of the inhibition of factor_Xa or thrombin by antithrombin using a covalent antithrombin-heparin complex .
14575696	0	factor_Xa	84,93	antithrombin	55,67	factor Xa	antithrombin	2159	462	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|compound|END_ENTITY	Platelet_factor_4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor_Xa by preventing interaction -LRB- s -RRB- of enzyme with polysaccharide .
15005625	0	factor_Xa	85,94	antithrombin	133,145	factor Xa	antithrombin	2159	462	Gene	Gene	reactivity|nmod|START_ENTITY mechanism|nmod|reactivity understanding|dobj|mechanism understanding|nmod|END_ENTITY	Mutagenesis studies toward understanding the mechanism of differential reactivity of factor_Xa with the native and heparin-activated antithrombin .
16515805	0	factor_Xa	35,44	antithrombin	59,71	factor Xa	antithrombin	2159	462	Gene	Gene	dependence|nmod|START_ENTITY inhibition|nsubj|dependence inhibition|nmod|END_ENTITY	Heparin chain-length dependence of factor_Xa inhibition by antithrombin in plasma .
21800826	0	factor_Xa	93,102	antithrombin	50,62	factor Xa	antithrombin	2159	462	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Designing nonsaccharide , allosteric activators of antithrombin for accelerated inhibition of factor_Xa .
24678194	0	factor_Xa	95,104	antithrombin	78,90	factor Xa	antithrombin	2159	462	Gene	Gene	inhibition|compound|START_ENTITY Elucidating|nmod|inhibition Elucidating|dobj|specificity specificity|nmod|activators activators|nmod|END_ENTITY	Elucidating the specificity of non-heparin-based conformational activators of antithrombin for factor_Xa inhibition .
9521646	0	factor_Xa	76,85	antithrombin	29,41	factor Xa	antithrombin	2159	462	Gene	Gene	conversion|nmod|START_ENTITY conversion|nmod|END_ENTITY	Conformational conversion of antithrombin to a fully activated substrate of factor_Xa without need for heparin .
8236146	0	factor_Xa	80,89	beta_2-glycoprotein_I	51,72	factor Xa	beta 2-glycoprotein I	2159	350	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Anticardiolipin antibodies block the inhibition by beta_2-glycoprotein_I of the factor_Xa generating activity of platelets .
23211396	0	factor_Xa	68,77	darexaban	42,51	factor Xa	factor Xa	2159	2159	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Effect of food on the pharmacokinetics of darexaban , an oral direct factor_Xa inhibitor , in healthy Japanese subjects .
15550696	0	factor_Xa	12,21	interleukin-8	33,46	factor Xa	interleukin-8	2159	3576	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Coagulation factor_Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes : implications in acute_myocardial_infarction .
8980646	0	factor_Xa	24,33	plasminogen_activator_inhibitor_type_1	37,75	factor Xa	plasminogen activator inhibitor type 1	2159	5054	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of human factor_Xa by plasminogen_activator_inhibitor_type_1 in the presence of calcium ion , and its enhancement by heparin and vitronectin .
1665594	0	factor_Xa	55,64	platelet_factor_4	109,126	factor Xa	platelet factor 4	2159	5196	Gene	Gene	inactivation|nmod|START_ENTITY heparin-catalyzed|dobj|inactivation weight|acl|heparin-catalyzed weight|dep|effect effect|nmod|END_ENTITY	Low molecular weight heparin-catalyzed inactivation of factor_Xa and thrombin by antithrombin III -- effect of platelet_factor_4 .
9616153	0	factor_Xa	33,42	protein_C	20,29	factor Xa	protein C	2159	5624	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Rapid activation of protein_C by factor_Xa and thrombin in the presence of polyanionic compounds .
15897196	0	factor_Xa	102,111	prothrombin	87,98	factor Xa	prothrombin	2159	2147	Gene	Gene	required|nmod|START_ENTITY required|nmod|cleavage cleavage|nmod|END_ENTITY	Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor_Xa .
16042383	0	factor_Xa	65,74	prothrombin	148,159	factor Xa	prothrombin	2159	2147	Gene	Gene	sequence|nmod|START_ENTITY residues|nmod|sequence mapping|nmod|residues mapping|dep|evidence evidence|dep|site site|nmod|END_ENTITY	Functional mapping of charged residues of the 82-116 sequence in factor_Xa : evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex .
3787558	0	factor_Xa	80,89	prothrombin	21,32	factor Xa	prothrombin	2159	2147	Gene	Gene	variant|nmod|START_ENTITY variant|compound|END_ENTITY	Prothrombin Clamart : prothrombin variant with defective Arg 320-IIe cleavage by factor_Xa .
489543	0	factor_Xa	69,78	prothrombin	36,47	factor Xa	prothrombin	2159	2147	Gene	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|activation activation|nmod|END_ENTITY	Kinetics of the activation of human prothrombin by human coagulation factor_Xa .
7852276	0	factor_Xa	18,27	prothrombin	88,99	factor Xa	prothrombin	2159	2147	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|sequence sequence|nmod|domain domain|nmod|END_ENTITY	Blood_coagulation factor_Xa interacts with a linear sequence of the kringle 2 domain of prothrombin .
7559509	0	factor_Xa	57,66	prothrombinase	74,88	factor Xa	prothrombinase	2159	2159	Gene	Gene	START_ENTITY|nmod|complex complex|amod|END_ENTITY	Protease nexin-2 / amyloid beta-protein precursor inhibits factor_Xa in the prothrombinase complex .
10089309	0	factor_Xa	82,91	thrombin	14,22	factor Xa	thrombin	2159	2147	Gene	Gene	relate|nmod|START_ENTITY retro-inhibited|advcl|relate retro-inhibited|nsubj|Structures Structures|nmod|END_ENTITY	Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor_Xa binding .
15882894	0	factor_Xa	27,36	thrombin	59,67	factor Xa	thrombin	2159	2147	Gene	Gene	Effect|nmod|START_ENTITY inhibitor|nsubj|Effect inhibitor|xcomp|DX-9065a DX-9065a|nmod|generation generation|compound|END_ENTITY	Effect of the novel direct factor_Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic_coronary_artery_disease .
17388799	0	factor_Xa	104,113	thrombin	23,31	factor Xa	thrombin	2159	2147	Gene	Gene	rivaroxaban|compound|START_ENTITY activation|nmod|rivaroxaban activation|nmod|inhibition inhibition|nmod|generation generation|compound|END_ENTITY	In vitro inhibition of thrombin generation , after tissue factor pathway activation , by the oral , direct factor_Xa inhibitor rivaroxaban .
17462889	0	factor_Xa	34,43	thrombin	77,85	factor Xa	thrombin	2159	2147	Gene	Gene	inhibitors|nsubj|START_ENTITY inhibitors|nmod|inhibitors inhibitors|nmod|END_ENTITY	From selective substrate analogue factor_Xa inhibitors to dual inhibitors of thrombin and factor_Xa .
19561526	0	factor_Xa	55,64	thrombin	76,84	factor Xa	thrombin	2159	2147	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Novel anticoagulants in clinical development : focus on factor_Xa and direct thrombin inhibitors .
2459011	0	factor_Xa	4,13	thrombin	37,45	factor Xa	thrombin	2159	2147	Gene	Gene	inhibitors|compound|START_ENTITY superior|nsubj|inhibitors superior|xcomp|END_ENTITY	Are factor_Xa inhibitors superior to thrombin inhibitors in anticoagulation ?
25457584	0	factor_Xa	164,173	thrombin	140,148	factor Xa	thrombin	2159	2147	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|inhibitors inhibitors|compound|END_ENTITY	A meta-analysis of phase III randomized controlled trials with novel oral anticoagulants in atrial_fibrillation : Comparisons between direct thrombin inhibitors vs. factor_Xa inhibitors and different dosing regimens .
2968979	0	factor_Xa	136,145	thrombin	36,44	factor Xa	thrombin	2159	2147	Gene	Gene	thrombin|appos|START_ENTITY inhibition|nmod|thrombin mechanisms|nmod|inhibition explains|dobj|mechanisms explains|nsubj|structure structure|nmod|complex complex|amod|END_ENTITY	A predicted tertiary structure of a thrombin inhibitor-trypsin complex explains the mechanisms of the selective inhibition of thrombin , factor_Xa , plasmin , and trypsin .
7641380	0	factor_Xa	31,40	thrombin	8,16	factor Xa	thrombin	2159	2147	Gene	Gene	compared|nmod|START_ENTITY compared|nsubj|Role Role|nmod|END_ENTITY	Role of thrombin compared with factor_Xa in the procoagulant activity of whole blood_clots .
8470046	0	factor_Xa	35,44	thrombin	160,168	factor Xa	thrombin	2159	2147	Gene	Gene	inhibition|compound|START_ENTITY assay|nmod|inhibition provides|nsubj|assay provides|advcl|identify identify|nmod|assay assay|acl|based based|nmod|inhibition inhibition|compound|END_ENTITY	An antithrombin_III assay based on factor_Xa inhibition provides a more reliable test to identify congenital antithrombin_III deficiency than an assay based on thrombin inhibition .
9364987	0	factor_Xa	61,70	thrombin	14,22	factor Xa	thrombin	2159	2147	Gene	Gene	inhibitors|nmod|START_ENTITY Inhibition|nmod|inhibitors Inhibition|nmod|generation generation|compound|END_ENTITY	Inhibition of thrombin generation in plasma by inhibitors of factor_Xa .
2442161	0	factor_Xa	84,93	vitronectin	51,62	factor Xa	vitronectin	2159	7448	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Neutralization and binding of heparin by S_protein / vitronectin in the inhibition of factor_Xa by antithrombin III .
15634274	0	factor_Xa_and_factor_IXa	50,74	epidermal_growth_factor-like	10,38	factor Xa and factor IXa	epidermal growth factor-like	2159	85476	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	The first epidermal_growth_factor-like domains of factor_Xa_and_factor_IXa are important for the activation of the factor VII -- tissue factor complex .
21704616	0	factor_for_adipocyte_differentiation_104	22,62	fad104	64,70	factor for adipocyte differentiation 104	fad104	72007(Tax:10090)	72007(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Indispensable role of factor_for_adipocyte_differentiation_104 -LRB- fad104 -RRB- in lung maturation .
14629629	0	factor_h	63,71	c4b-binding_protein	83,102	factor h	c4b-binding protein	3075	722	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|amod|END_ENTITY	Ontogeny of complement regulatory proteins - concentrations of factor_h , factor I , c4b-binding_protein , properdin and vitronectin in healthy children of different ages and in adults .
23463631	0	factor_inhibiting_ATF4-mediated_transcription	17,62	Fiat	11,15	factor inhibiting ATF4-mediated transcription	Fiat	353170(Tax:10090)	353170(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Control of Fiat -LRB- factor_inhibiting_ATF4-mediated_transcription -RRB- expression by Sp family transcription factors in osteoblasts .
24465898	0	factor_inhibiting_HIF	12,33	FIH-1	35,40	factor inhibiting HIF	FIH-1	55662	55662	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of factor_inhibiting_HIF -LRB- FIH-1 -RRB- in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme .
17873238	0	factor_xa	28,37	thrombin	80,88	factor xa	thrombin	2159	2147	Gene	Gene	inhibitor|compound|START_ENTITY Effects|nmod|inhibitor rivaroxaban|nsubj|Effects rivaroxaban|nmod|generation generation|compound|END_ENTITY	Effects of the oral , direct factor_xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity .
1112820	0	factors_V_and_X-a	57,74	antithrombin	96,108	factors V and X-a	antithrombin	2159	462	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of human prothrombin by highly purified human factors_V_and_X-a in presence of human antithrombin .
21704616	0	fad104	64,70	factor_for_adipocyte_differentiation_104	22,62	fad104	factor for adipocyte differentiation 104	72007(Tax:10090)	72007(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Indispensable role of factor_for_adipocyte_differentiation_104 -LRB- fad104 -RRB- in lung maturation .
9868173	0	fak	76,79	leptin_receptor	54,69	fak	leptin receptor	25614(Tax:10116)	24536(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Phenotypic consequences of a nonsense mutation in the leptin_receptor gene -LRB- fak -RRB- in obese spontaneously hypertensive Koletsky rats -LRB- SHROB -RRB- .
12537263	0	familial_Mediterranean_fever	33,61	Hip	0,3	familial Mediterranean fever	Hip	4210	6159	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Hip involvement in patients with familial_Mediterranean_fever .
15681246	0	familial_Mediterranean_fever	27,55	Interferon-gamma	0,16	familial Mediterranean fever	Interferon-gamma	4210	3458	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Interferon-gamma levels in familial_Mediterranean_fever .
10807793	0	familial_Mediterranean_fever	13,41	MEFV	43,47	familial Mediterranean fever	MEFV	4210	4210	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for familial_Mediterranean_fever , MEFV , is expressed in early leukocyte development and is regulated in response to inflammatory mediators .
14727057	0	familial_Mediterranean_fever	18,46	MEFV	0,4	familial Mediterranean fever	MEFV	4210	4210	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	MEFV mutations in familial_Mediterranean_fever : association of M694V homozygosity with arthritis .
18328141	0	familial_Mediterranean_fever	26,54	MEFV	0,4	familial Mediterranean fever	MEFV	4210	4210	Gene	Gene	analysis|nmod|START_ENTITY analysis|amod|END_ENTITY	MEFV mutation analysis of familial_Mediterranean_fever in Japan .
19784369	0	familial_Mediterranean_fever	25,53	MEFV	60,64	familial Mediterranean fever	MEFV	4210	4210	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the familial_Mediterranean_fever gene -LRB- MEFV -RRB- and risk for Crohn 's _ disease and ulcerative_colitis .
19863562	0	familial_Mediterranean_fever	54,82	MEFV	0,4	familial Mediterranean fever	MEFV	4210	4210	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	MEFV mutations in Iranian Azeri Turkish patients with familial_Mediterranean_fever .
8374487	0	familial_Mediterranean_fever	25,53	hip	6,9	familial Mediterranean fever	hip	4210	6159	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Total hip replacement in familial_Mediterranean_fever .
15515781	0	familial_Mediterranean_fever	68,96	interleukin-6	10,23	familial Mediterranean fever	interleukin-6	4210	3569	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	Levels of interleukin-6 -LRB- IL-6 -RRB- and its soluble receptor -LRB- sIL-6R -RRB- in familial_Mediterranean_fever -LRB- FMF -RRB- patients and their first degree relatives .
10522869	0	familial_adult_myoclonic_epilepsy	28,61	FAME	63,67	familial adult myoclonic epilepsy	FAME	50968	50968	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic localization of the familial_adult_myoclonic_epilepsy -LRB- FAME -RRB- gene to chromosome 8q24 .
11472751	0	familial_hypercholesterolemia	36,65	C-reactive_protein	0,18	familial hypercholesterolemia	C-reactive protein	3949	1401	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	C-reactive_protein in patients with familial_hypercholesterolemia : no effect of simvastatin therapy .
18602518	0	familial_hypercholesterolemia	84,113	C-reactive_protein	12,30	familial hypercholesterolemia	C-reactive protein	3949	1401	Gene	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of C-reactive_protein and carotid_intima_media_thickness in Taiwanese with familial_hypercholesterolemia .
19467224	0	familial_hypercholesterolemia	97,126	LDLR	84,88	familial hypercholesterolemia	LDLR	3949	3949	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	An apparent inconsistency in parent to offspring transmission of point mutations of LDLR gene in familial_hypercholesterolemia .
19013141	0	familial_hypercholesterolemia	67,96	LDL_receptor	42,54	familial hypercholesterolemia	LDL receptor	3949	3949	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	A novel method for determining functional LDL_receptor activity in familial_hypercholesterolemia : application of the CD3/CD28 assay in lymphocytes .
11668627	0	familial_hypercholesterolemia	81,110	Low_density_lipoprotein_receptor	0,32	familial hypercholesterolemia	Low density lipoprotein receptor	3949	3949	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene mutations in Canadian subjects with familial_hypercholesterolemia , but not of French descent .
6290485	0	familial_hypercholesterolemia	56,85	Low_density_lipoprotein_receptor	0,32	familial hypercholesterolemia	Low density lipoprotein receptor	3949	3949	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Low_density_lipoprotein_receptor activity in homozygous familial_hypercholesterolemia fibroblasts .
15178557	0	familial_hypercholesterolemia	124,153	PCSK9	19,24	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	implicated|nmod|START_ENTITY convertase-1|acl|implicated encoding|dobj|convertase-1 gene|acl|encoding END_ENTITY|appos|gene	Statins upregulate PCSK9 , the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial_hypercholesterolemia .
17435765	0	familial_hypercholesterolemia	70,99	PCSK9	38,43	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	linked|nmod|START_ENTITY linked|nsubj|studies studies|nmod|END_ENTITY	Structural and biophysical studies of PCSK9 and its mutants linked to familial_hypercholesterolemia .
17765244	0	familial_hypercholesterolemia	86,115	PCSK9	56,61	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|Identification Identification|nmod|mutants mutants|compound|END_ENTITY	Identification and characterization of two non-secreted PCSK9 mutants associated with familial_hypercholesterolemia in cohorts from New Zealand and South Africa .
19917273	0	familial_hypercholesterolemia	111,140	PCSK9	38,43	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	heterozygotes|compound|START_ENTITY cholesterol|nmod|heterozygotes levels|nmod|cholesterol impact|nmod|levels has|dobj|impact has|nsubj|R46L R46L|nmod|gene gene|compound|END_ENTITY	Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial_hypercholesterolemia heterozygotes .
22375030	0	familial_hypercholesterolemia	53,82	PCSK9	17,22	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of PCSK9 and phenotypic variability in familial_hypercholesterolemia .
24632287	0	familial_hypercholesterolemia	119,148	PCSK9	16,21	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	patients|nmod|START_ENTITY detrimental|nmod|patients detrimental|nsubj|level level|compound|END_ENTITY	Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial_hypercholesterolemia and heterozygous familial_hypercholesterolemia , irrespective of low-density_lipoprotein_receptor defects .
25014035	0	familial_hypercholesterolemia	48,77	PCSK9	135,140	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	features|nmod|START_ENTITY caused|nsubj|features caused|nmod|mutation mutation|appos|END_ENTITY	Genotypic and phenotypic features in homozygous familial_hypercholesterolemia caused by proprotein_convertase_subtilisin / kexin_type_9 -LRB- PCSK9 -RRB- gain-of-function mutation .
25313916	0	familial_hypercholesterolemia	132,161	PCSK9	210,215	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	lipoprotein-apheresis|nmod|START_ENTITY kexin_9|nmod|lipoprotein-apheresis kexin_9|dep|development development|nmod|assay assay|nmod|END_ENTITY	Removal of plasma mature and furin-cleaved proprotein_convertase_subtilisin / kexin_9 -LRB- PCSK9 -RRB- by low-density lipoprotein-apheresis in familial_hypercholesterolemia : development and application of a new assay for PCSK9 .
25313916	0	familial_hypercholesterolemia	132,161	PCSK9	85,90	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	lipoprotein-apheresis|nmod|START_ENTITY kexin_9|nmod|lipoprotein-apheresis kexin_9|appos|END_ENTITY	Removal of plasma mature and furin-cleaved proprotein_convertase_subtilisin / kexin_9 -LRB- PCSK9 -RRB- by low-density lipoprotein-apheresis in familial_hypercholesterolemia : development and application of a new assay for PCSK9 .
26371983	0	familial_hypercholesterolemia	63,92	PCSK9	20,25	familial hypercholesterolemia	PCSK9	3949	255738	Gene	Gene	severity|nmod|START_ENTITY levels|nmod|severity levels|nummod|END_ENTITY	The contribution of PCSK9 levels to the phenotypic severity of familial_hypercholesterolemia is independent of LDL_receptor genotype .
10416810	0	familial_hypercholesterolemia	38,67	Thrombomodulin	0,14	familial hypercholesterolemia	Thrombomodulin	3949	7056	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Thrombomodulin levels in asymptomatic familial_hypercholesterolemia .
3606467	0	familial_hypercholesterolemia	55,84	apolipoprotein_E	35,51	familial hypercholesterolemia	apolipoprotein E	3949	348	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Plasma lipoprotein distribution of apolipoprotein_E in familial_hypercholesterolemia .
9889019	0	familial_hypercholesterolemia	98,127	low-density_lipoprotein_receptor	10,42	familial hypercholesterolemia	low-density lipoprotein receptor	3949	3949	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Two novel low-density_lipoprotein_receptor gene mutations -LRB- E397X and 347delGCC -RRB- in St. Petersburg familial_hypercholesterolemia .
2726768	0	familial_hypercholesterolemia	135,164	low_density_lipoprotein-receptor	68,100	familial hypercholesterolemia	low density lipoprotein-receptor	3949	3949	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Identification of a point mutation in growth factor repeat C of the low_density_lipoprotein-receptor gene in a patient with homozygous familial_hypercholesterolemia that affects ligand binding and intracellular movement of receptors .
11642133	0	familial_hypercholesterolemia	102,131	low_density_lipoprotein_receptor	52,84	familial hypercholesterolemia	low density lipoprotein receptor	3949	3949	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	-LSB- Four new mutations and polymorphic variants of the low_density_lipoprotein_receptor in patients with familial_hypercholesterolemia in Saint Petersburg -RSB- .
18247305	0	familial_hypercholesterolemia	85,114	low_density_lipoprotein_receptor	47,79	familial hypercholesterolemia	low density lipoprotein receptor	3949	3949	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Mutation screening and functional analysis of low_density_lipoprotein_receptor in a familial_hypercholesterolemia family -RSB- .
1911722	0	familial_hypercholesterolemia	220,249	low_density_lipoprotein_receptor	179,211	familial hypercholesterolemia	low density lipoprotein receptor	3949	3949	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Serum low density lipoprotein cholesterol level and cholesterol absorption efficiency are influenced by apolipoprotein_B and E polymorphism and by the FH-Helsinki mutation of the low_density_lipoprotein_receptor gene in familial_hypercholesterolemia .
8168830	0	familial_hypercholesterolemia	104,133	low_density_lipoprotein_receptor	46,78	familial hypercholesterolemia	low density lipoprotein receptor	3949	3949	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	A new missense mutation -LRB- Cys297 -- > Phe -RRB- of the low_density_lipoprotein_receptor in Italian patients with familial_hypercholesterolemia -LRB- FHTrieste -RRB- .
9039332	0	familial_hypocalciuric_hypercalcaemia	38,75	Calcium-sensing_receptor	0,24	familial hypocalciuric hypercalcaemia	Calcium-sensing receptor	846	846	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Calcium-sensing_receptor mutations in familial_hypocalciuric_hypercalcaemia with recurrent pancreatitis .
22984288	0	family_with_sequence_similarity_60_member_A	6,49	FAM60A	51,57	family with sequence similarity 60 member A	FAM60A	58516	58516	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Human family_with_sequence_similarity_60_member_A -LRB- FAM60A -RRB- protein : a new subunit of the Sin3 deacetylase complex .
11222755	0	far_upstream_element-binding_protein	48,84	DNA_helicase_V	24,38	far upstream element-binding protein	DNA helicase V	8880	8880	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human DNA_helicase_V with the far_upstream_element-binding_protein .
12519787	0	farnesoid_X_receptor	56,76	FXR	78,81	farnesoid X receptor	FXR	9971	9971	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Retinoid_X_receptor -LRB- RXR -RRB- agonist-induced antagonism of farnesoid_X_receptor -LRB- FXR -RRB- activity due to absence of coactivator recruitment and decreased DNA binding .
14733360	0	farnesoid_X_receptor	25,45	FXR	47,50	farnesoid X receptor	FXR	9971	9971	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Ligand-binding domain of farnesoid_X_receptor -LRB- FXR -RRB- had the highest sensitivity and activity among FXR variants in a fluorescence-based assay .
23073079	0	farnesoid_X_receptor	32,52	FXR	54,57	farnesoid X receptor	FXR	9971	9971	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The significance of the nuclear farnesoid_X_receptor -LRB- FXR -RRB- in b cell function .
24875360	0	farnesoid_X_receptor	14,34	FXR	36,39	farnesoid X receptor	FXR	20186(Tax:10090)	20186(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of farnesoid_X_receptor -LRB- FXR -RRB- protects against fructose-induced liver_steatosis via inflammatory inhibition and ADRP reduction .
25156247	0	farnesoid_X_receptor	22,42	FXR	103,106	farnesoid X receptor	FXR	20186(Tax:10090)	20186(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Protective effects of farnesoid_X_receptor -LRB- FXR -RRB- on hepatic_lipid_accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal .
26337021	0	farnesoid_X_receptor	102,122	FXR	124,127	farnesoid X receptor	FXR	9971	9971	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery and SAR study of 3 - -LRB- tert-butyl -RRB- -4 - hydroxyphenyl_benzoate and benzamide derivatives as novel farnesoid_X_receptor -LRB- FXR -RRB- antagonists .
23431047	0	farnesoid_X_receptor	71,91	Ldlr	95,99	farnesoid X receptor	Ldlr	20186(Tax:10090)	16835(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of bile_acid and cholesterol metabolism by the farnesoid_X_receptor in Ldlr - / - mice versus hamsters .
16682417	0	farnesoid_X_receptor	35,55	Pregnane_X_receptor	0,19	farnesoid X receptor	Pregnane X receptor	20186(Tax:10090)	18171(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Pregnane_X_receptor is a target of farnesoid_X_receptor .
24291500	0	farnesoid_X_receptor	14,34	RECK	43,47	farnesoid X receptor	RECK	20186(Tax:10090)	53614(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|dobj|expression expression|compound|END_ENTITY	Activation of farnesoid_X_receptor induces RECK expression in mouse liver .
18842595	0	farnesoid_X_receptor	52,72	SHP	92,95	farnesoid X receptor	SHP	20186(Tax:10090)	23957(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	The p300 acetylase is critical for ligand-activated farnesoid_X_receptor -LRB- FXR -RRB- induction of SHP .
17655523	0	farnesoid_X_receptor	4,24	fetuin-B	33,41	farnesoid X receptor	fetuin-B	9971	26998	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The farnesoid_X_receptor induces fetuin-B gene expression in human hepatocytes .
21511916	0	farnesoid_X_receptor	52,72	microRNA-29a	9,21	farnesoid X receptor	microRNA-29a	9971	407021	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Roles of microRNA-29a in the antifibrotic effect of farnesoid_X_receptor in hepatic stellate cells .
15147890	0	farnesoid_X_receptor	4,24	very_low_density_lipoprotein_receptor	33,70	farnesoid X receptor	very low density lipoprotein receptor	20186(Tax:10090)	22359(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	The farnesoid_X_receptor induces very_low_density_lipoprotein_receptor gene expression .
20104269	0	farnesoid_x_receptor	46,66	cdx2	18,22	farnesoid x receptor	cdx2	60351(Tax:10116)	66019(Tax:10116)	Gene	Gene	induce|nmod|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Bile_acids induce cdx2 expression through the farnesoid_x_receptor in gastric epithelial cells .
11401336	0	fas_antigen	17,28	CD_95	30,35	fas antigen	CD 95	355	355	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Possible role of fas_antigen -LRB- CD_95 -RRB- in human_amniotic_epithelial cell death : an in vitro study .
10677522	0	fas_ligand	22,32	CD8	65,68	fas ligand	CD8	356	925	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|regulation regulation|nmod|+ +|compound|END_ENTITY	The dual functions of fas_ligand in the regulation of peripheral CD8 + and CD4 + T cells .
10200015	0	fas_ligand	23,33	CD95L	35,40	fas ligand	CD95L	356	356	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of fas_ligand -LRB- CD95L -RRB- on T cells after segmental allergen provocation in asthma .
12161534	0	fas_ligand	14,24	IL-8	39,43	fas ligand	IL-8	356	3576	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of fas_ligand expression by IL-8 in human endometrium .
11014819	0	fasciclin_II	63,75	Semaphorin-1a	0,13	fasciclin II	Semaphorin-1a	31364(Tax:7227)	34192(Tax:7227)	Gene	Gene	concert|nmod|START_ENTITY acts|nmod|concert acts|nsubj|END_ENTITY	Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin_II and connectin to regulate axon fasciculation in Drosophila .
19199094	0	fasciculation_and_elongation_protein_zeta-1	14,57	FEZ1	59,63	fasciculation and elongation protein zeta-1	FEZ1	81730(Tax:10116)	81730(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- in cultured rat neonatal astrocytes .
20730382	0	fasciculation_and_elongation_protein_zeta-1	13,56	FEZ1	58,62	fasciculation and elongation protein zeta-1	FEZ1	9638	9638	Gene	Gene	Functions|nmod|START_ENTITY Functions|appos|END_ENTITY	Functions of fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- in the brain .
11856312	0	fasciculation_and_elongation_protein_zeta-1	20,63	NBR1	0,4	fasciculation and elongation protein zeta-1	NBR1	235180(Tax:10090)	17966(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	NBR1 interacts with fasciculation_and_elongation_protein_zeta-1 -LRB- FEZ1 -RRB- and calcium_and_integrin_binding_protein -LRB- CIB -RRB- and shows developmentally restricted expression in the neural tube .
23393326	0	fascin-1	21,29	FSCN1	31,36	fascin-1	FSCN1	6624	6624	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	Prognostic impact of fascin-1 -LRB- FSCN1 -RRB- in epithelial_ovarian_cancer .
11745351	0	fasl	17,21	Sp1	0,3	fasl	Sp1	14103(Tax:10090)	20683(Tax:10090)	Gene	Gene	activator|amod|START_ENTITY activator|nsubj|END_ENTITY	Sp1 is the major fasl gene activator in abnormal CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- B220 -LRB- + -RRB- T cells of lpr and gld mice .
18081944	0	fasting-induced_adipose_factor	42,72	angiopoietin-like_protein_4	14,41	fasting-induced adipose factor	angiopoietin-like protein 4	57875(Tax:10090)	57875(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|/ /|amod|END_ENTITY	Regulation of angiopoietin-like_protein_4 / fasting-induced_adipose_factor -LRB- Angptl4/FIAF -RRB- expression in mouse white_adipose_tissue and 3T3-L1 adipocytes .
9010133	0	fat_body_protein_2	45,63	FBP2	70,74	fat body protein 2	FBP2	34259(Tax:7227)	34259(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Selection and methionine accumulation in the fat_body_protein_2 gene -LRB- FBP2 -RRB- , a duplicate of the Drosophila alcohol_dehydrogenase -LRB- ADH -RRB- gene .
19554614	0	fatty-acid_binding_protein	45,71	FABP	73,77	fatty-acid binding protein	FABP	2806	2806	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Association analyses between brain-expressed fatty-acid_binding_protein -LRB- FABP -RRB- genes and schizophrenia and bipolar_disorder .
18682402	0	fatty-acid_synthase	85,104	FASN	111,115	fatty-acid synthase	FASN	2194	2194	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Proto-oncogene FBI-1 -LRB- Pokemon -RRB- and SREBP-1 synergistically activate transcription of fatty-acid_synthase gene -LRB- FASN -RRB- .
8681947	0	fatty-acid_transporter	53,75	FAT	77,80	fatty-acid transporter	FAT	948	948	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and regulation of the putative membrane fatty-acid_transporter -LRB- FAT -RRB- in the small intestine .
17217945	0	fatty_acid_amide_hydrolase	77,103	CB1	120,123	fatty acid amide hydrolase	CB1	14073(Tax:10090)	12801(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Assessment of anandamide 's pharmacological effects in mice deficient_of_both fatty_acid_amide_hydrolase and cannabinoid CB1 receptors .
21175570	0	fatty_acid_amide_hydrolase	14,40	CB1	49,52	fatty acid amide hydrolase	CB1	14073(Tax:10090)	12801(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY unmasks|nsubj|Inhibition unmasks|dobj|receptor receptor|compound|END_ENTITY	Inhibition of fatty_acid_amide_hydrolase unmasks CB1 receptor and TRPV1 channel-mediated modulation of glutamatergic synaptic transmission in midbrain periaqueductal grey .
17553686	0	fatty_acid_amide_hydrolase	25,51	FAAH	53,57	fatty acid amide hydrolase	FAAH	2166	2166	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Severe deficiency of the fatty_acid_amide_hydrolase -LRB- FAAH -RRB- activity segregates with the Huntington 's _ disease mutation in peripheral lymphocytes .
19554599	0	fatty_acid_amide_hydrolase	63,89	FAAH	91,95	fatty acid amide hydrolase	FAAH	2166	2166	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure-property relationships of a class of carbamate-based fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors : chemical and biological stability .
20570023	0	fatty_acid_amide_hydrolase	67,93	FAAH	95,99	fatty acid amide hydrolase	FAAH	2166	2166	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Chemistry around imidazopyrazine and ibuprofen : discovery of novel fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors .
21820769	0	fatty_acid_amide_hydrolase	33,59	FAAH	61,65	fatty acid amide hydrolase	FAAH	29347(Tax:10116)	29347(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Biphenyl-3-yl_alkylcarbamates as fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors : steric effects of N-alkyl chain on rat plasma and liver stability .
23218778	0	fatty_acid_amide_hydrolase	83,109	FAAH	111,115	fatty acid amide hydrolase	FAAH	14073(Tax:10090)	14073(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis , SAR study , and biological evaluation of a series of piperazine ureas as fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors .
24275607	0	fatty_acid_amide_hydrolase	14,40	FAAH	42,46	fatty acid amide hydrolase	FAAH	2166	2166	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- as a novel therapeutic strategy in the treatment of pain and inflammatory_diseases in the gastrointestinal tract .
25338703	0	fatty_acid_amide_hydrolase	62,88	FAAH	90,94	fatty acid amide hydrolase	FAAH	29347(Tax:10116)	29347(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	O - -LRB- triazolyl -RRB- methyl_carbamates as a novel and potent class of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors .
26558620	0	fatty_acid_amide_hydrolase	11,37	FAAH	39,43	fatty acid amide hydrolase	FAAH	29347(Tax:10116)	29347(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of fatty_acid_amide_hydrolase -LRB- FAAH -RRB- inhibitors on working memory in rats .
24244493	0	fatty_acid_binding_protein_4_and_5	19,53	FABP4/5	55,62	fatty acid binding protein 4 and 5	FABP4/5	11770(Tax:10090)	11770;16592	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A critical role of fatty_acid_binding_protein_4_and_5 -LRB- FABP4/5 -RRB- in the systemic response to fasting .
19661213	0	fatty_acid_omega-hydroxylase	47,75	CYP4V2	35,41	fatty acid omega-hydroxylase	CYP4V2	1579	285440	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and characterization of CYP4V2 as a fatty_acid_omega-hydroxylase .
10103003	0	fatty_acid_synthase	33,52	FAS	54,57	fatty acid synthase	FAS	50671(Tax:10116)	50671(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	FIRE3 in the promoter of the rat fatty_acid_synthase -LRB- FAS -RRB- gene binds the ubiquitous transcription factors CBF_and_USF but does not mediate an insulin response in a rat hepatoma cell line .
12766036	0	fatty_acid_synthase	35,54	FAS	56,59	fatty acid synthase	FAS	2194	2194	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the lipogenic enzyme fatty_acid_synthase -LRB- FAS -RRB- in retinoblastoma and its correlation with tumor_aggressiveness .
15235125	0	fatty_acid_synthase	14,33	FAS	35,38	fatty acid synthase	FAS	2194	2194	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of fatty_acid_synthase -LRB- FAS -RRB- suppresses HER2/neu -LRB- erbB-2 -RRB- oncogene overexpression in cancer cells .
19223187	0	fatty_acid_synthase	6,25	FAS	27,30	fatty acid synthase	FAS	2194	2194	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Novel fatty_acid_synthase -LRB- FAS -RRB- inhibitors : design , synthesis , biological evaluation , and molecular docking studies .
8630954	0	fatty_acid_synthase	14,33	FAS	35,38	fatty acid synthase	FAS	2194	2194	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of fatty_acid_synthase -LRB- FAS -RRB- as a predictor of recurrence in stage I breast_carcinoma patients .
17786030	0	fatty_acid_synthase	47,66	FASN	68,72	fatty acid synthase	FASN	2194	2194	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Caveolin-1 is required for the upregulation of fatty_acid_synthase -LRB- FASN -RRB- , a tumor promoter , during prostate_cancer progression .
23928534	0	fatty_acid_synthase	15,34	HER2	60,64	fatty acid synthase	HER2	2194	2064	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of fatty_acid_synthase and its association with HER2 in invasive_ductal_carcinoma of breast -RSB- .
15669079	1	fatty_acid_synthase	167,186	vascular_endothelial_growth_factor	264,298	fatty acid synthase	vascular endothelial growth factor	2194	7422	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Characterization of a novel molecular connection between fatty_acid_synthase -LRB- FAS -RRB- and hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- - related expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in cancer cells overexpressing her-2 / neu oncogene .
21826159	0	fe	22,24	Faded	15,20	fe	Faded	14150(Tax:10090)	14150(Tax:10090)	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Mapping of the Faded -LRB- fe -RRB- Gene to a Region between D10mit191 and D10mit44 on Mouse Chromosome 10 .
22199353	0	fe65	63,67	notch1	19,25	fe65	notch1	322	4851	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Dual regulation of notch1 signaling pathway by adaptor protein fe65 .
9811568	0	female_sterile_homeotic	105,128	Fsrg1	33,38	female sterile homeotic	Fsrg1	31722(Tax:7227)	14312(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Expression and potential role of Fsrg1 , a murine bromodomain-containing homologue of the Drosophila gene female_sterile_homeotic .
2294399	0	fer	9,12	ferT	41,45	fer	ferT	14158(Tax:10090)	14158(Tax:10090)	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	A murine fer testis-specific transcript -LRB- ferT -RRB- encodes a truncated Fer protein .
2294399	0	ferT	41,45	fer	9,12	ferT	fer	14158(Tax:10090)	14158(Tax:10090)	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	A murine fer testis-specific transcript -LRB- ferT -RRB- encodes a truncated Fer protein .
24141188	0	ferredoxin	18,28	PETF	30,34	ferredoxin	PETF	5716653(Tax:3055)	5718285(Tax:3055)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of ferredoxin , PETF , enhances tolerance to heat_stress in Chlamydomonas_reinhardtii .
24799178	0	ferredoxin-NADP_reductase	57,82	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	ferredoxin-NADP reductase	Glyceraldehyde-3-phosphate dehydrogenase	2232	2597	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase is regulated by ferredoxin-NADP_reductase in the diatom Asterionella formosa .
23533643	0	ferritin	85,93	HLH-29	75,81	ferritin	HLH-29	171934(Tax:6239)	185136(Tax:6239)	Gene	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Genome-wide microarrray analysis reveals roles for the REF-1 family member HLH-29 in ferritin synthesis and peroxide stress response .
7797515	0	ferritin_H	41,51	NF-kappa_B	9,19	ferritin H	NF-kappa B	67634(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role for NF-kappa_B in the regulation of ferritin_H by tumor_necrosis_factor-alpha .
12435735	0	ferritin_H	31,41	Nrf2	0,4	ferritin H	Nrf2	67634(Tax:10090)	18024(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	Nrf2 mediates the induction of ferritin_H in response to xenobiotics and cancer chemopreventive dithiolethiones .
1783383	0	ferrochelatase	24,38	FECH	45,49	ferrochelatase	FECH	2235	2235	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the human ferrochelatase gene -LRB- FECH -RRB- and a locus for protoporphyria to chromosome 18q22 .
15897636	0	ferroportin_1	37,50	IREG1	52,57	ferroportin 1	IREG1	30061	30061	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hemochromatosis with mutation of the ferroportin_1 -LRB- IREG1 -RRB- gene .
12091367	0	ferroportin_1	99,112	SLC11A3	119,126	ferroportin 1	SLC11A3	30061	30061	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin_1 gene -LRB- SLC11A3 -RRB- .
10788627	0	ferroxidase	58,69	Fet3	107,111	ferroxidase	Fet3	851437(Tax:4932)	855080(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The essential role of Glu-185 and Tyr-354 residues in the ferroxidase activity of Saccharomyces_cerevisiae Fet3 .
11342541	0	fertilin_alpha	12,26	ADAM1	28,33	fertilin alpha	ADAM1	280668(Tax:10090)	280668(Tax:10090)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of fertilin_alpha -LRB- ADAM1 -RRB- - mediated sperm-egg cell adhesion during fertilization and identification of an adhesion-mediating sequence in the disintegrin-like domain .
12095680	0	fertilin_alpha	51,65	ADAM1	44,49	fertilin alpha	ADAM1	280667(Tax:10090)	280668(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	The ADAM1a and ADAM1b genes , instead of the ADAM1 -LRB- fertilin_alpha -RRB- gene , are localized on mouse chromosome 5 .
11906941	0	fertilin_beta	131,144	ADAM2	146,151	fertilin beta	ADAM2	11495(Tax:10090)	11495(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Analysis of the roles of RGD-binding integrins , alpha -LRB- 4 -RRB- / alpha -LRB- 9 -RRB- integrins , alpha -LRB- 6 -RRB- integrins , and CD9 in the interaction of the fertilin_beta -LRB- ADAM2 -RRB- disintegrin domain with the mouse egg membrane .
16894551	0	fertilization_antigen	10,31	FA-1	33,37	fertilization antigen	FA-1	20826(Tax:10090)	20826(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of fertilization_antigen -LRB- FA-1 -RRB- DNA vaccine on fertility of female mice .
9378851	0	fetal_ALZ-50_reactive_clone_1	14,43	FAC1	45,49	fetal ALZ-50 reactive clone 1	FAC1	2186	2186	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of fetal_ALZ-50_reactive_clone_1 -LRB- FAC1 -RRB- in dentate gyrus_following_entorhinal_cortex_lesion .
15928041	0	fetal_liver_kinase-1	47,67	Runx1	15,20	fetal liver kinase-1	Runx1	16542(Tax:10090)	12394(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY down-regulation|nmod|expression END_ENTITY|nmod|down-regulation	Involvement of Runx1 in the down-regulation of fetal_liver_kinase-1 expression during transition of endothelial cells to hematopoietic cells .
11723743	0	fetal_liver_kinase-1	113,133	vascular_endothelial_growth_factor	14,48	fetal liver kinase-1	vascular endothelial growth factor	3791	7422	Gene	Gene	Flk-1|dep|START_ENTITY Expression|dep|Flk-1 Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor KDR -LRB- kinase_domain-containing_receptor -RRB- / Flk-1 -LRB- fetal_liver_kinase-1 -RRB- as prognostic factors in human colorectal_cancer .
15780476	0	fetal_liver_kinase-1	60,80	vascular_endothelial_growth_factor	15,49	fetal liver kinase-1	vascular endothelial growth factor	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Reduction of a vascular_endothelial_growth_factor receptor , fetal_liver_kinase-1 , by antisense oligonucleotides induces motor neuron_death in rat spinal cord exposed to hypoxia .
2403740	0	feto-acinar_pancreatic_protein	33,63	FAP	65,68	feto-acinar pancreatic protein	FAP	1056	1056	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	An immunohistologic study of the feto-acinar_pancreatic_protein -LRB- FAP -RRB- in the normal pancreas , chronic pancreatitis , pancreatic_adenocarcinoma , and intraabdominal metastases of adenocarcinomas .
26585510	0	fetuin-A	7,15	TLR4	49,53	fetuin-A	TLR4	197	7099	Gene	Gene	correlate|nsubj|START_ENTITY correlate|nmod|END_ENTITY	Plasma fetuin-A does not correlate with monocyte TLR4 in humans .
26068716	0	fetuin-A	35,43	aryl_hydrocarbon_receptor	63,88	fetuin-A	aryl hydrocarbon receptor	197	196	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Indoxyl_sulfate suppresses hepatic fetuin-A expression via the aryl_hydrocarbon_receptor in HepG2 cells .
17970775	0	fetuin-A	59,67	fibroblast_growth_factor-23	24,51	fetuin-A	fibroblast growth factor-23	197	8074	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Relation between plasma fibroblast_growth_factor-23 , serum fetuin-A levels and coronary_artery_calcification evaluated by multislice computed tomography in patients with normal kidney function .
22387701	0	fetuin-A	16,24	insulin	52,59	fetuin-A	insulin	197	3630	Gene	Gene	levels|amod|START_ENTITY Relationship|nmod|levels Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship of fetuin-A levels to weight-dependent insulin resistance and type_2_diabetes_mellitus .
17655523	0	fetuin-B	33,41	farnesoid_X_receptor	4,24	fetuin-B	farnesoid X receptor	26998	9971	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The farnesoid_X_receptor induces fetuin-B gene expression in human hepatocytes .
26105582	0	fetuin_A	106,114	sirtuin_1	96,105	fetuin A	sirtuin 1	197	23411	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Fenofibrate reduces inflammation in obese patients with or without type_2_diabetes_mellitus via sirtuin_1 / fetuin_A axis .
26105582	0	fetuin_A	106,114	sirtuin_1	96,105	fetuin A	sirtuin 1	197	23411	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Fenofibrate reduces inflammation in obese patients with or without type_2_diabetes_mellitus via sirtuin_1 / fetuin_A axis .
18950725	0	ff1a	20,24	Sox9a	0,5	ff1a	Sox9a	30749(Tax:7955)	60641(Tax:7955)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Sox9a regulation of ff1a in zebrafish -LRB- Danio_rerio -RRB- suggests an involvement of ff1a in cartilage development .
18950725	0	ff1a	79,83	Sox9a	0,5	ff1a	Sox9a	30749(Tax:7955)	60641(Tax:7955)	Gene	Gene	involvement|nmod|START_ENTITY suggests|dobj|involvement suggests|nsubj|regulation regulation|amod|END_ENTITY	Sox9a regulation of ff1a in zebrafish -LRB- Danio_rerio -RRB- suggests an involvement of ff1a in cartilage development .
10704877	0	ff1b	54,58	Ftz-F1	36,42	ff1b	Ftz-F1	83916(Tax:7955)	30749(Tax:7955)	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Developmental expression of a novel Ftz-F1 homologue , ff1b -LRB- NR5A4 -RRB- , in the zebrafish Danio_rerio .
12925590	0	fgf24	10,15	fgf8	31,35	fgf24	fgf8	359831(Tax:7955)	30538(Tax:7955)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development .
12925590	0	fgf8	31,35	fgf24	10,15	fgf8	fgf24	30538(Tax:7955)	359831(Tax:7955)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development .
9782336	0	fgl2	18,22	prothrombinase	48,62	fgl2	prothrombinase	14190(Tax:10090)	14190(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the fgl2 and its protein product -LRB- prothrombinase -RRB- in tissues during murine hepatitis virus strain-3 -LRB- MHV-3 -RRB- infection .
11509230	0	fibrillarin	79,90	survival_of_motor_neurons	4,29	fibrillarin	survival of motor neurons	2091	6606	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The survival_of_motor_neurons -LRB- SMN -RRB- protein interacts with the snoRNP proteins fibrillarin and GAR1 .
12402346	0	fibrillin-1	26,37	FBN1	39,43	fibrillin-1	FBN1	2200	2200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation screening of the fibrillin-1 -LRB- FBN1 -RRB- gene in 76 unrelated patients with Marfan_syndrome or Marfanoid features leads to the identification of 11 novel and three previously reported mutations .
17984934	0	fibrillin-1	109,120	FBN1	122,126	fibrillin-1	FBN1	2200	2200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel non-synonymous mutation in the transforming_growth_factor_beta binding protein-like -LRB- TB -RRB- domain of the fibrillin-1 -LRB- FBN1 -RRB- gene in a Han Chinese family with Marfan_syndrome -LRB- MFS -RRB- .
19839986	0	fibrillin-1	25,36	FBN1	38,42	fibrillin-1	FBN1	2200	2200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation spectrum of the fibrillin-1 -LRB- FBN1 -RRB- gene in Taiwanese patients with Marfan_syndrome .
22950452	0	fibrillin-1	108,119	FBN1	126,130	fibrillin-1	FBN1	2200	2200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ophthalmic findings in a family with early-onset isolated_ectopia_lentis and the p.Arg62Cys mutation of the fibrillin-1 gene -LRB- FBN1 -RRB- .
23860323	0	fibrillin-1	14,25	Sp1	45,48	fibrillin-1	Sp1	2200	6667	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of fibrillin-1 gene expression by Sp1 .
10417681	0	fibrillin-1	131,142	elastin	122,129	fibrillin-1	elastin	2200	2006	Gene	Gene	component|amod|START_ENTITY component|amod|END_ENTITY	Degenerative processes of elastic fibers in sun-protected and sun-exposed skin : immunoelectron microscopic observation of elastin , fibrillin-1 , amyloid P component , lysozyme and alpha1-antitrypsin .
21540769	0	fibrillin-1	72,83	elastin	38,45	fibrillin-1	elastin	2200	2006	Gene	Gene	immunolocalization|amod|START_ENTITY immunolocalization|nmod|proteins proteins|amod|END_ENTITY	Comparative immunolocalization of the elastin fiber-associated proteins fibrillin-1 , LTBP-2 , and MAGP-1 with components of the collagenous and proteoglycan matrix of the fetal human intervertebral disc .
25586891	0	fibrillin-1	11,22	elastin	35,42	fibrillin-1	elastin	2200	2006	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Changes in fibrillin-1 expression , elastin expression and skin surface texture at sites of cultured epithelial autograft transplantation onto wounds from burn_scar_excision .
10417681	0	fibrillin-1	131,142	lysozyme	165,173	fibrillin-1	lysozyme	2200	4069	Gene	Gene	component|amod|START_ENTITY observation|nmod|component observation|amod|END_ENTITY	Degenerative processes of elastic fibers in sun-protected and sun-exposed skin : immunoelectron microscopic observation of elastin , fibrillin-1 , amyloid P component , lysozyme and alpha1-antitrypsin .
17984934	0	fibrillin-1	109,120	transforming_growth_factor_beta	37,68	fibrillin-1	transforming growth factor beta	2200	7040	Gene	Gene	gene|amod|START_ENTITY domain|nmod|gene domain|amod|END_ENTITY	Novel non-synonymous mutation in the transforming_growth_factor_beta binding protein-like -LRB- TB -RRB- domain of the fibrillin-1 -LRB- FBN1 -RRB- gene in a Han Chinese family with Marfan_syndrome -LRB- MFS -RRB- .
22822613	0	fibrinogen	38,48	CRP	15,18	fibrinogen	CRP	2244	1401	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of CRP and serum level of fibrinogen with severity of disease in chronic_obstructive_pulmonary_disease patients .
25888123	0	fibrinogen	37,47	C_reactive_protein	17,35	fibrinogen	C reactive protein	2244	1401	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	High sensitivity C_reactive_protein , fibrinogen levels and the onset of major depressive_disorder in post-acute_coronary_syndrome .
25888123	0	fibrinogen	37,47	C_reactive_protein	17,35	fibrinogen	C reactive protein	2244	1401	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	High sensitivity C_reactive_protein , fibrinogen levels and the onset of major depressive_disorder in post-acute_coronary_syndrome .
17532489	0	fibrinogen	21,31	FG	33,35	fibrinogen	FG	2244	2244	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Correlates of plasma fibrinogen -LRB- FG -RRB- levels in a random sample of community-dwelling elderly .
16362348	0	fibrinogen	48,58	FGA	28,31	fibrinogen	FGA	2244	2243	Gene	Gene	polymorphisms|appos|START_ENTITY polymorphisms|nmod|END_ENTITY	Functional polymorphisms of FGA , encoding alpha fibrinogen , are associated with susceptibility to venous_thromboembolism in a Taiwanese population .
12893758	0	fibrinogen	98,108	FGB	84,87	fibrinogen	FGB	2244	2244	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Congenital_afibrinogenemia : identification and expression of a missense mutation in FGB impairing fibrinogen secretion .
14630795	0	fibrinogen	52,62	FGF-2	42,47	fibrinogen	FGF-2	2244	2247	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|site site|nmod|END_ENTITY	Identification of a binding site on human FGF-2 for fibrinogen .
15297314	0	fibrinogen	74,84	FGF-2	49,54	fibrinogen	FGF-2	2244	2247	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3 .
15604525	0	fibrinogen	47,57	FXR	35,38	fibrinogen	FXR	2244	9971	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the nuclear receptor FXR induces fibrinogen expression : a new role for bile_acid signaling .
8839849	0	fibrinogen	53,63	Fibulin-1	0,9	fibrinogen	Fibulin-1	2244	2192	Gene	Gene	bridge|nmod|START_ENTITY platelet_adhesion|nmod|bridge mediates|dobj|platelet_adhesion mediates|nsubj|END_ENTITY	Fibulin-1 mediates platelet_adhesion via a bridge of fibrinogen .
9241743	0	fibrinogen	33,43	H1/H2	44,49	fibrinogen	H1/H2	2244	3009	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	Positive association of the beta fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary_artery_disease and myocardial_infarction .
9241743	0	fibrinogen	74,84	H1/H2	44,49	fibrinogen	H1/H2	2244	3009	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Positive association of the beta fibrinogen H1/H2 gene variation to basal fibrinogen levels and to the increase in fibrinogen concentration during acute phase reaction but not to coronary_artery_disease and myocardial_infarction .
16123330	0	fibrinogen	59,69	IL-1beta	31,39	fibrinogen	IL-1beta	2244	3553	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Endothelial cell activation by IL-1beta in the presence of fibrinogen requires alphavbeta3 .
10514513	0	fibrinogen	51,61	Insulin-like_growth_factor-binding_protein-3	0,44	fibrinogen	Insulin-like growth factor-binding protein-3	2244	3486	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Insulin-like_growth_factor-binding_protein-3 binds fibrinogen and fibrin .
15039285	0	fibrinogen	45,55	Interleukin-1beta	0,17	fibrinogen	Interleukin-1beta	2244	3553	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form .
11229826	0	fibrinogen	98,108	P-selectin	18,28	fibrinogen	P-selectin	2244	6403	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Increased soluble P-selectin in patients with haematological and breast_cancer : a comparison with fibrinogen , plasminogen activator inhibitor and von_Willebrand factor .
11511124	0	fibrinogen	30,40	P-selectin	53,63	fibrinogen	P-selectin	2244	6403	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Plasma von_Willebrand factor , fibrinogen and soluble P-selectin levels in paroxysmal , persistent and permanent atrial_fibrillation .
12850842	0	fibrinogen	84,94	P-selectin	61,71	fibrinogen	P-selectin	2244	6403	Gene	Gene	binding|amod|START_ENTITY Roxifiban|amod|binding Roxifiban|nmod|expression expression|amod|END_ENTITY	Effects of the glycoprotein IIb/IIIa antagonist Roxifiban on P-selectin expression , fibrinogen binding , and microaggregate formation in a phase I dose-finding study : no evidence for platelet activation during treatment with a glycoprotein IIb/IIIa antagonist .
19262138	0	fibrinogen	66,76	P-selectin	0,10	fibrinogen	P-selectin	2244	6403	Gene	Gene	PSGL-1|nmod|START_ENTITY PSGL-1|nsubj|cross-links cross-links|amod|END_ENTITY	P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent , but GPCR-independent mechanism .
2140913	0	fibrinogen	27,37	Plasmin	0,7	fibrinogen	Plasmin	2244	5340	Gene	Gene	digestion|nmod|START_ENTITY digestion|compound|END_ENTITY	Plasmin digestion of human fibrinogen previously phosphorylated by protein kinase C or dephosphorylated by alkaline phosphatase in vitro .
2524834	0	fibrinogen	60,70	Plasmin	0,7	fibrinogen	Plasmin	2244	5340	Gene	Gene	immobilized|dobj|START_ENTITY lipoprotein|acl|immobilized binding|nmod|lipoprotein catalyzes|dobj|binding catalyzes|nsubj|END_ENTITY	Plasmin catalyzes binding of lipoprotein -LRB- a -RRB- to immobilized fibrinogen and fibrin .
2617455	0	fibrinogen	42,52	Plasminogen	0,11	fibrinogen	Plasminogen	2244	5340	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Plasminogen interactions with immobilized fibrinogen .
11401083	0	fibrinogen	48,58	Thrombin	0,8	fibrinogen	Thrombin	2244	2147	Gene	Gene	oxidized|dobj|START_ENTITY oxygen|acl:relcl|oxidized converts|dobj|oxygen converts|nsubj|END_ENTITY	Thrombin converts singlet oxygen -LRB- 1O2 -RRB- - oxidized fibrinogen into a soluble t-PA cofactor .
1581297	0	fibrinogen	50,60	Thrombin	0,8	fibrinogen	Thrombin	2244	2147	Gene	Gene	Lille|compound|START_ENTITY peptide|nmod|Lille hydrolysis|nmod|peptide hydrolysis|compound|END_ENTITY	Thrombin hydrolysis of an N-terminal peptide from fibrinogen Lille : kinetic and NMR studies .
8726231	0	fibrinogen	58,68	Thrombin	0,8	fibrinogen	Thrombin	2244	2147	Gene	Gene	activity|compound|START_ENTITY accumulation|nmod|activity reduce|dobj|accumulation inhibitors|xcomp|reduce inhibitors|nsubj|END_ENTITY	Thrombin inhibitors reduce intrapulmonary accumulation of fibrinogen and procoagulant activity of bronchoalveolar lavage fluid during acute_lung_injury induced by pulmonary_overdistention in newborn piglets .
9326231	0	fibrinogen	44,54	Thrombin	0,8	fibrinogen	Thrombin	2244	2147	Gene	Gene	deposition|nmod|START_ENTITY deposition|amod|END_ENTITY	Thrombin cleavage-independent deposition of fibrinogen in extracellular matrices .
19358279	0	fibrinogen	34,44	VE-cadherin	4,15	fibrinogen	VE-cadherin	2244	1003	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial_migration of malignant breast epithelial cells .
11090059	0	fibrinogen	44,54	Vascular_endothelial_growth_factor	0,34	fibrinogen	Vascular endothelial growth factor	2244	7422	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Vascular_endothelial_growth_factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation .
3217923	0	fibrinogen	13,23	alpha-chain	26,37	fibrinogen	alpha-chain	2244	2217	Gene	Gene	Isolation|nmod|START_ENTITY Isolation|dep|END_ENTITY	Isolation of fibrinogen A alpha-chain by affinity chromatography on concanavalin A-sepharose .
9516457	0	fibrinogen	45,55	basic_fibroblast_growth_factor	11,41	fibrinogen	basic fibroblast growth factor	2244	2247	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of basic_fibroblast_growth_factor to fibrinogen and fibrin .
23000409	0	fibrinogen	33,43	carboxypeptidase_N	11,29	fibrinogen	carboxypeptidase N	2244	1369	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of carboxypeptidase_N to fibrinogen and fibrin .
14559115	0	fibrinogen	103,113	fibrinogen	55,65	fibrinogen	fibrinogen	2244	2244	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|compound|END_ENTITY	Congenital_afibrinogenemia : intracellular retention of fibrinogen due to a novel W437G mutation in the fibrinogen Bbeta-chain gene .
14559115	0	fibrinogen	55,65	fibrinogen	103,113	fibrinogen	fibrinogen	2244	2244	Gene	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Congenital_afibrinogenemia : intracellular retention of fibrinogen due to a novel W437G mutation in the fibrinogen Bbeta-chain gene .
20348140	0	fibrinogen	12,22	fibrinogen	47,57	fibrinogen	fibrinogen	2244	2244	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery .
20348140	0	fibrinogen	47,57	fibrinogen	12,22	fibrinogen	fibrinogen	2244	2244	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery .
23157111	0	fibrinogen	15,25	fibrinogen	72,82	fibrinogen	fibrinogen	2244	2244	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	-LSB- Comparison of fibrinogen synthesis and secretion between novel variant fibrinogen , nagakute -LRB- gamma305Thr _ -- > _ Ala -RRB- , and other variants located in gamma305-308 residues -RSB- .
23157111	0	fibrinogen	72,82	fibrinogen	15,25	fibrinogen	fibrinogen	2244	2244	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	-LSB- Comparison of fibrinogen synthesis and secretion between novel variant fibrinogen , nagakute -LRB- gamma305Thr _ -- > _ Ala -RRB- , and other variants located in gamma305-308 residues -RSB- .
2830287	0	fibrinogen	51,61	fibrinogen	90,100	fibrinogen	fibrinogen	2244	2244	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Molecular and supramolecular structure of adsorbed fibrinogen and adsorption isotherms of fibrinogen at quartz surfaces .
2830287	0	fibrinogen	90,100	fibrinogen	51,61	fibrinogen	fibrinogen	2244	2244	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Molecular and supramolecular structure of adsorbed fibrinogen and adsorption isotherms of fibrinogen at quartz surfaces .
505378	0	fibrinogen	27,37	fibrinogen	48,58	fibrinogen	fibrinogen	2244	2244	Gene	Gene	products|compound|START_ENTITY products|compound|END_ENTITY	The accelerating effect of fibrinogen and early fibrinogen degradation products on erythrocyte sedimentation .
505378	0	fibrinogen	48,58	fibrinogen	27,37	fibrinogen	fibrinogen	2244	2244	Gene	Gene	products|compound|START_ENTITY products|compound|END_ENTITY	The accelerating effect of fibrinogen and early fibrinogen degradation products on erythrocyte sedimentation .
7642629	0	fibrinogen	34,44	fibulin-1	19,28	fibrinogen	fibulin-1	2244	2192	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of fibulin-1 with fibrinogen .
7586584	0	fibrinogen	82,92	haptoglobin	45,56	fibrinogen	haptoglobin	2244	3240	Gene	Gene	relationships|nmod|START_ENTITY Components|dep|relationships Components|nmod|variation variation|nmod|END_ENTITY	Components of biological variation in plasma haptoglobin : relationships to plasma fibrinogen and immune variables , including interleukin-6 and its receptor .
6695362	0	fibrinogen	66,76	high_molecular_weight_kininogen	14,45	fibrinogen	high molecular weight kininogen	2244	3827	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of high_molecular_weight_kininogen on surface-adsorbed fibrinogen .
3958188	0	fibrinogen	48,58	histidine-rich_glycoprotein	15,42	fibrinogen	histidine-rich glycoprotein	2244	3273	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of histidine-rich_glycoprotein with fibrinogen and fibrin .
12007734	0	fibrinogen	55,65	intercellular_adhesion_molecule-1	16,49	fibrinogen	intercellular adhesion molecule-1	2244	3383	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of intercellular_adhesion_molecule-1 with fibrinogen .
15736117	0	fibrinogen	95,105	intercellular_adhesion_molecule-1	30,63	fibrinogen	intercellular adhesion molecule-1	2244	3383	Gene	Gene	level|compound|START_ENTITY associated|nmod|level associated|nsubjpass|polymorphism polymorphism|nmod|gene gene|amod|END_ENTITY	The K469E polymorphism of the intercellular_adhesion_molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes .
19332210	0	fibrinogen	148,158	intercellular_adhesion_molecule-1	87,120	fibrinogen	intercellular adhesion molecule-1	2244	3383	Gene	Gene	genes|nmod|START_ENTITY genes|amod|END_ENTITY	Candidate genetic variants in the fibrinogen , methylenetetrahydrofolate_reductase , and intercellular_adhesion_molecule-1 genes and plasma levels of fibrinogen , homocysteine , and intercellular_adhesion_molecule-1 among various race/ethnic groups : data from the Women 's Genome Health Study .
7822297	0	fibrinogen	34,44	intercellular_adhesion_molecule-1	79,112	fibrinogen	intercellular adhesion molecule-1	2244	3383	Gene	Gene	sequence|compound|START_ENTITY recognition|nmod|sequence recognition|nmod|interaction interaction|amod|END_ENTITY	Structural recognition of a novel fibrinogen gamma chain sequence -LRB- 117-133 -RRB- by intercellular_adhesion_molecule-1 mediates leukocyte-endothelium interaction .
9182580	0	fibrinogen	23,33	intercellular_adhesion_molecule-1	51,84	fibrinogen	intercellular adhesion molecule-1	2244	3383	Gene	Gene	action|nmod|START_ENTITY mediated|nsubj|action mediated|advcl|END_ENTITY	A mitogenic action for fibrinogen mediated through intercellular_adhesion_molecule-1 .
10226077	0	fibrinogen	65,75	interleukin-1beta	34,51	fibrinogen	interleukin-1beta	2244	3553	Gene	Gene	engagement|compound|START_ENTITY promoter|nmod|engagement promoter|amod|END_ENTITY	Transcriptional regulation of the interleukin-1beta promoter via fibrinogen engagement of the CD18 integrin receptor .
18380966	0	fibrinogen	11,21	interleukin-1beta	42,59	fibrinogen	interleukin-1beta	2244	3553	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of fibrinogen on the secretion of interleukin-1beta and - 8 by polymorphonuclear leukocytes -RSB- .
11224491	0	fibrinogen	86,96	interleukin-6	69,82	fibrinogen	interleukin-6	2244	3569	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	The effect of the interleukin-6 c/g -174 polymorphism and circulating interleukin-6 on fibrinogen plasma levels .
9879291	0	fibrinogen	56,66	interleukin-6	15,28	fibrinogen	interleukin-6	2244	3569	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Involvement of interleukin-6 in the elevation of plasma fibrinogen levels in lung_cancer patients .
126232	0	fibrinogen	36,46	plasmin	61,68	fibrinogen	plasmin	2244	5340	Gene	Gene	cleavage|nmod|START_ENTITY re-examination|nmod|cleavage re-examination|nmod|END_ENTITY	A re-examination of the cleavage of fibrinogen and fibrin by plasmin .
1387746	0	fibrinogen	41,51	plasmin	55,62	fibrinogen	plasmin	2244	5340	Gene	Gene	hydrolysis|nmod|START_ENTITY arginine|nmod|hydrolysis effect|nmod|arginine -LSB-|dobj|effect -LSB-|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- The effect of arginine on hydrolysis of fibrinogen by plasmin and mini-plasmin -RSB- .
148116	0	fibrinogen	66,76	plasmin	29,36	fibrinogen	plasmin	2244	5340	Gene	Gene	Radioimmunoassay|nmod|START_ENTITY Radioimmunoassay|nmod|product product|compound|END_ENTITY	Radioimmunoassay of an early plasmin degradation product of human fibrinogen , `` fragment A '' , and its clinical application .
149393	0	fibrinogen	108,118	plasmin	59,66	fibrinogen	plasmin	2244	5340	Gene	Gene	cleavage|nmod|START_ENTITY protease|dobj|cleavage protease|nsubj|characterization characterization|nmod|products products|nmod|END_ENTITY	Comparative immunochemical characterization of products of plasmin and leukocyte protease cleavage of human fibrinogen .
1531588	0	fibrinogen	97,107	plasmin	111,118	fibrinogen	plasmin	2244	5340	Gene	Gene	digestion|nmod|START_ENTITY differing|nmod|digestion differing|nmod|END_ENTITY	Generation of forms of fragment E with differing thrombin-binding properties during digestion of fibrinogen by plasmin .
16029886	0	fibrinogen	30,40	plasmin	79,86	fibrinogen	plasmin	2244	5340	Gene	Gene	surfaces|amod|START_ENTITY processing|nmod|surfaces processing|dep|effect effect|nmod|generation generation|compound|END_ENTITY	Electrochemical processing of fibrinogen modified-graphite surfaces : effect on plasmin generation from adsorbed plasminogen .
19809304	0	fibrinogen	56,66	plasmin	12,19	fibrinogen	plasmin	2244	5340	Gene	Gene	generation|nmod|START_ENTITY generation|amod|END_ENTITY	Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia , BbetaGly15Cys -LRB- Hamamatsu II -RRB- .
2143650	0	fibrinogen	25,35	plasmin	14,21	fibrinogen	plasmin	2244	5340	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of plasmin by fibrinogen .
2151408	0	fibrinogen	45,55	plasmin	34,41	fibrinogen	plasmin	2244	5340	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of soluble and immobilized plasmin on fibrinogen and platelets .
2478231	0	fibrinogen	58,68	plasmin	82,89	fibrinogen	plasmin	2244	5340	Gene	Gene	chain|nmod|START_ENTITY sequences|nmod|chain constitute|nsubj|sequences constitute|dobj|epitope epitope|amod|END_ENTITY	The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin .
2935535	0	fibrinogen	24,34	plasmin	56,63	fibrinogen	plasmin	2244	5340	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of adsorbed fibrinogen by surface-generated plasmin .
2938303	0	fibrinogen	27,37	plasmin	63,70	fibrinogen	plasmin	2244	5340	Gene	Gene	characteristics|nmod|START_ENTITY hydrolysis|nsubj|characteristics hydrolysis|nmod|END_ENTITY	Kinetic characteristics of fibrinogen and fibrin hydrolysis by plasmin 1 and 2 and miniplasmin .
2958955	0	fibrinogen	18,28	plasmin	85,92	fibrinogen	plasmin	2244	5340	Gene	Gene	variant|compound|START_ENTITY variant|nmod|absence absence|nmod|effect effect|nmod|calcium calcium|nmod|degradation degradation|compound|END_ENTITY	Fibrinogen Haifa : fibrinogen variant with absence of protective effect of calcium on plasmin degradation of gamma chains .
4222714	0	fibrinogen	38,48	plasmin	64,71	fibrinogen	plasmin	2244	5340	Gene	Gene	forming|nmod|START_ENTITY products|acl|forming proteolysis|nsubj|products proteolysis|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Thermostable products forming during fibrinogen proteolysis by plasmin -RSB- .
4222954	0	fibrinogen	66,76	plasmin	93,100	fibrinogen	plasmin	2244	5340	Gene	Gene	START_ENTITY|nmod|use use|nmod|END_ENTITY	-LSB- Fractionation and properties of early products of proteolysis of fibrinogen with the use of plasmin -RSB- .
4229209	0	fibrinogen	18,28	plasmin	62,69	fibrinogen	plasmin	2244	5340	Gene	Gene	products|nmod|START_ENTITY Split|dobj|products Split|nmod|interaction interaction|nmod|END_ENTITY	Split products of fibrinogen after prolonged interaction with plasmin .
47328	0	fibrinogen	72,82	plasmin	110,117	fibrinogen	plasmin	2244	5340	Gene	Gene	regions|nmod|START_ENTITY modulation|nmod|regions associated|nsubj|modulation associated|nmod|cleavage cleavage|compound|END_ENTITY	Conformational and structural modulation of the NH2-terminal regions of fibrinogen and fibrin associated with plasmin cleavage .
6216917	0	fibrinogen	91,101	plasmin	103,110	fibrinogen	plasmin	2244	5340	Gene	Gene	START_ENTITY|dep|fragments fragments|compound|END_ENTITY	Anticoagulant and calcium-binding properties of high molecular weight derivatives of human fibrinogen -LRB- plasmin fragments Y -RRB- .
6219709	0	fibrinogen	81,91	plasmin	46,53	fibrinogen	plasmin	2244	5340	Gene	Gene	hydrolysis|nmod|START_ENTITY role|nmod|hydrolysis role|nmod|END_ENTITY	The role of the lysine binding sites of human plasmin in the hydrolysis of human fibrinogen .
6223426	0	fibrinogen	27,37	plasmin	65,72	fibrinogen	plasmin	2244	5340	Gene	Gene	evaluation|nmod|START_ENTITY hydrolysis|nsubj|evaluation hydrolysis|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Comparative evaluation of fibrinogen and fibrin hydrolysis with plasmin -RSB- .
6240993	0	fibrinogen	55,65	plasmin	42,49	fibrinogen	plasmin	2244	5340	Gene	Gene	E|compound|START_ENTITY END_ENTITY|nmod|E	-LSB- Interaction of heavy and light chains of plasmin with fibrinogen E and D fragments -RSB- .
6453618	0	fibrinogen	91,101	plasmin	115,122	fibrinogen	plasmin	2244	5340	Gene	Gene	derivatives|nmod|START_ENTITY properties|nmod|derivatives produced|nsubj|properties produced|nmod|END_ENTITY	Anticoagulant and calcium-binding properties of high molecular weight derivatives of human fibrinogen , produced by plasmin -LRB- fragments X -RRB- .
7798686	0	fibrinogen	11,21	plasmin	68,75	fibrinogen	plasmin	2244	5340	Gene	Gene	START_ENTITY|nmod|acquisition acquisition|nmod|END_ENTITY	A role for fibrinogen in the streptokinase-dependent acquisition of plasmin -LRB- ogen -RRB- by group A streptococci .
11460477	0	fibrinogen	42,52	plasminogen_activator_inhibitor_2	57,90	fibrinogen	plasminogen activator inhibitor 2	2244	5055	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of crosslinking sites in fibrinogen for plasminogen_activator_inhibitor_2 -LRB- PAI-2 -RRB- .
8006883	0	fibrinogen	97,107	serum_amyloid_A	53,68	fibrinogen	serum amyloid A	2244	6287	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Synergism of interleukin_1 and interleukin_6 induces serum_amyloid_A production while depressing fibrinogen : a quantitative analysis .
10637	0	fibrinogen	14,24	thrombin	62,70	fibrinogen	thrombin	2244	2147	Gene	Gene	sites|amod|START_ENTITY Reactivity|nmod|sites Reactivity|nmod|absence absence|nmod|END_ENTITY	Reactivity of fibrinogen crosslinking sites in the absence of thrombin .
10837485	0	fibrinogen	12,22	thrombin	43,51	fibrinogen	thrombin	2244	2147	Gene	Gene	studies|compound|START_ENTITY reveal|nsubj|studies reveal|ccomp|dictates dictates|nsubj|specificity specificity|compound|END_ENTITY	Recombinant fibrinogen studies reveal that thrombin specificity dictates order of fibrinopeptide release .
10891092	0	fibrinogen	50,60	thrombin	29,37	fibrinogen	thrombin	2244	2147	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Mutation of W215 compromises thrombin cleavage of fibrinogen , but not of PAR-1 or protein C. W215 is a highly conserved residue that shapes the S3 and S4 specificity sites of thrombin and participates in an edge-to-face interaction with residue F8 of the fibrinogen Aalpha chain .
11460501	0	fibrinogen	50,60	thrombin	29,37	fibrinogen	thrombin	2244	2147	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Mutation of W215 compromises thrombin cleavage of fibrinogen , but not of PAR1 or protein C. W215 is a highly conserved residue that shapes the S3 and S4 specificity sites of thrombin .
1149268	0	fibrinogen	30,40	thrombin	50,58	fibrinogen	thrombin	2244	2147	Gene	Gene	method|nmod|START_ENTITY based|nsubj|method based|nmod|measurement measurement|amod|END_ENTITY	An improved method for plasma fibrinogen based on thrombin time measurement .
1587268	0	fibrinogen	33,43	thrombin	19,27	fibrinogen	thrombin	2244	2147	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of thrombin with fibrinogen .
1621283	0	fibrinogen	19,29	thrombin	96,104	fibrinogen	thrombin	2244	2147	Gene	Gene	exogenous|acl|START_ENTITY Role|nmod|exogenous Role|acl|stimulated stimulated|nmod|END_ENTITY	-LSB- Role of exogenous fibrinogen in the processes of degranulation of thrombocytes stimulated with thrombin .
1634610	0	fibrinogen	19,29	thrombin	63,71	fibrinogen	thrombin	2244	2147	Gene	Gene	Naples|compound|START_ENTITY basis|nmod|Naples associated|nsubj|basis associated|nmod|END_ENTITY	Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia .
16962697	0	fibrinogen	46,56	thrombin	21,29	fibrinogen	thrombin	2244	2147	Gene	Gene	gamma|amod|START_ENTITY peptide|nmod:poss|gamma structure|nmod|peptide structure|nmod|END_ENTITY	Crystal structure of thrombin in complex with fibrinogen gamma ' peptide .
1706295	0	fibrinogen	66,76	thrombin	15,23	fibrinogen	thrombin	2244	2147	Gene	Gene	presence|nmod|START_ENTITY Interaction|nmod|presence Interaction|nmod|END_ENTITY	Interaction of thrombin with endothelial cells in the presence of fibrinogen and alpha_2-macroglobulin .
19513421	0	fibrinogen	26,36	thrombin	97,105	fibrinogen	thrombin	2244	2147	Gene	Gene	modification|nmod|START_ENTITY inhibits|nsubj|modification inhibits|nmod|effect effect|nmod|END_ENTITY	Oxidative modification of fibrinogen inhibits its transformation into fibrin under the effect of thrombin .
2053103	0	fibrinogen	22,32	thrombin	64,72	fibrinogen	thrombin	2244	2147	Gene	Gene	alpha|dep|START_ENTITY 27-50|amod|alpha analog|nmod|27-50 inhibitor|nsubj|analog inhibitor|nmod|END_ENTITY	A synthetic analog of fibrinogen alpha 27-50 is an inhibitor of thrombin .
21086376	0	fibrinogen	14,24	thrombin	35,43	fibrinogen	thrombin	2244	2147	Gene	Gene	Use|nmod|START_ENTITY END_ENTITY|dep|Use	-LSB- Use of human fibrinogen and human thrombin for urethral reconstructive surgery . -RSB-
22439748	0	fibrinogen	65,75	thrombin	49,57	fibrinogen	thrombin	2244	2147	Gene	Gene	y|compound|START_ENTITY chain|nmod:poss|y Role|nmod|chain Role|nmod|END_ENTITY	Role of electrostatic interactions in binding of thrombin to the fibrinogen y ' chain .
23360261	0	fibrinogen	2,12	thrombin	199,207	fibrinogen	thrombin	2244	2147	Gene	Gene	concentrate|nsubj|START_ENTITY concentrate|ccomp|reverse reverse|nmod|fibrinolysis fibrinolysis|acl|induced induced|nmod|END_ENTITY	A fibrinogen concentrate Haemocomplettan -LRB- Riastap -RRB- or a Factor XIII concentrate Fibrogammin combined with a mini dose of tranexamic_acid can reverse the fibrin instability to fibrinolysis induced by thrombin - or FXa-inhibitor .
25239831	0	fibrinogen	36,46	thrombin	61,69	fibrinogen	thrombin	2244	2147	Gene	Gene	hydrolysis|compound|START_ENTITY affect|dobj|hydrolysis affect|nmod|END_ENTITY	How does association process affect fibrinogen hydrolysis by thrombin ?
2642712	0	fibrinogen	16,26	thrombin	71,79	fibrinogen	thrombin	2244	2147	Gene	Gene	peptide|amod|START_ENTITY Expression|nmod|peptide Expression|dep|substrate substrate|compound|END_ENTITY	Expression of a fibrinogen fusion peptide in Escherichia_coli : a model thrombin substrate for structure/function analysis .
3053360	0	fibrinogen	24,34	thrombin	116,124	fibrinogen	thrombin	2244	2147	Gene	Gene	peptides|compound|START_ENTITY interaction|nmod|peptides derived|nsubj|interaction derived|nmod|presence presence|nmod|END_ENTITY	The interaction between fibrinogen and 3H-L-arginine cationic peptides derived from fibrosarcoma in the presence of thrombin .
3738860	0	fibrinogen	8,18	thrombin	44,52	fibrinogen	thrombin	2244	2147	Gene	Gene	derivatives|compound|START_ENTITY derivatives|acl|generated generated|nmod|END_ENTITY	Soluble fibrinogen derivatives generated by thrombin : affinity for elastin .
3750276	0	fibrinogen	96,106	thrombin	28,36	fibrinogen	thrombin	2244	2147	Gene	Gene	evaluation|nmod|START_ENTITY Adhesion|dep|evaluation Adhesion|nmod|platelets platelets|amod|END_ENTITY	Adhesion and aggregation of thrombin prestimulated human platelets : evaluation of surface-bound fibrinogen and surface-bound albumin .
3886645	1	fibrinogen	78,88	thrombin	94,102	fibrinogen	thrombin	2244	2147	Gene	Gene	interaction|nmod|START_ENTITY Effect|nmod|interaction Effect|nmod|END_ENTITY	Effect on the interaction of fibrinogen with thrombin from diethyl_pyrocarbonate-modified prothrombin .
3983914	0	fibrinogen	32,42	thrombin	75,83	fibrinogen	thrombin	2244	2147	Gene	Gene	gelation|nmod|START_ENTITY gelation|dep|thiol thiol|acl|enhanced enhanced|dep|END_ENTITY	FXIII induced gelation of human fibrinogen -- an alternative thiol enhanced , thrombin independent pathway .
4074798	0	fibrinogen	16,26	thrombin	93,101	fibrinogen	thrombin	2244	2147	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|acl|differing differing|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Interaction of fibrinogen with two forms of fibrin differing in the degree of activation by thrombin -RSB- .
4750457	0	fibrinogen	49,59	thrombin	30,38	fibrinogen	thrombin	2244	2147	Gene	Gene	clottable|dobj|START_ENTITY clottable|nsubj|method method|acl|estimating estimating|dobj|END_ENTITY	A batch method for estimating thrombin clottable fibrinogen .
5014617	0	fibrinogen	12,22	thrombin	100,108	fibrinogen	thrombin	2244	2147	Gene	Gene	antigen|compound|START_ENTITY Increase|nmod|antigen Increase|nmod|END_ENTITY	Increase in fibrinogen and fibrin-related antigen in human serum due to in vitro lysis of fibrin by thrombin .
5862557	0	fibrinogen	13,23	thrombin	109,117	fibrinogen	thrombin	2244	2147	Gene	Gene	Influence|nmod|START_ENTITY induced|nsubj|Influence induced|nmod|adenosine_diphosphate adenosine_diphosphate|appos|END_ENTITY	Influence of fibrinogen on the aggregation of washed human blood platelets induced by adenosine_diphosphate , thrombin , collagen , and adrenaline .
6417869	0	fibrinogen	11,21	thrombin	59,67	fibrinogen	thrombin	2244	2147	Gene	Gene	Sources|nmod|START_ENTITY Sources|nmod|END_ENTITY	Sources of fibrinogen for coagulum pyelolithotomy , without thrombin .
6444358	0	fibrinogen	67,77	thrombin	35,43	fibrinogen	thrombin	2244	2147	Gene	Gene	converted|nmod|START_ENTITY converted|nmod|END_ENTITY	Localizaton of fibrin converted by thrombin from released platelet fibrinogen .
6453297	0	fibrinogen	28,38	thrombin	55,63	fibrinogen	thrombin	2244	2147	Gene	Gene	beta|amod|START_ENTITY proteolysis|nmod|beta chain|nsubj|proteolysis chain|nmod|END_ENTITY	Relative proteolysis of the fibrinogen B beta chain by thrombin and plasmin as a determinant of thrombosis .
6626500	0	fibrinogen	35,45	thrombin	23,31	fibrinogen	thrombin	2244	2147	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of thrombin on fibrinogen .
6783348	1	fibrinogen	129,139	thrombin	110,118	fibrinogen	thrombin	2244	2147	Gene	Gene	clottable|dobj|START_ENTITY clottable|nsubj|comparison comparison|nmod|technique technique|nmod|END_ENTITY	A comparison of the technique against thrombin clottable fibrinogen with spectrophotometry and radial immuno-diffusion .
6800197	0	fibrinogen	76,86	thrombin	46,54	fibrinogen	thrombin	2244	2147	Gene	Gene	study|nmod|START_ENTITY study|nmod|conditions conditions|nmod|assay assay|compound|END_ENTITY	A study of the conditions and accuracy of the thrombin time assay of plasma fibrinogen .
7117668	0	fibrinogen	124,134	thrombin	14,22	fibrinogen	thrombin	2244	2147	Gene	Gene	residues|nmod|START_ENTITY interaction|nmod|residues Inhibition|dep|interaction Inhibition|nmod|cleavage cleavage|compound|END_ENTITY	Inhibition of thrombin cleavage of fibrinogen by polyestradiol_phosphate ; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage .
7117668	0	fibrinogen	35,45	thrombin	14,22	fibrinogen	thrombin	2244	2147	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Inhibition of thrombin cleavage of fibrinogen by polyestradiol_phosphate ; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage .
7150549	0	fibrinogen	35,45	thrombin	23,31	fibrinogen	thrombin	2244	2147	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of thrombin on fibrinogen .
7190836	0	fibrinogen	35,45	thrombin	23,31	fibrinogen	thrombin	2244	2147	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of thrombin on fibrinogen .
7900079	0	fibrinogen	17,27	thrombin	133,141	fibrinogen	thrombin	2244	2147	Gene	Gene	influence|nmod|START_ENTITY influence|dep|evidence evidence|nmod|activation activation|nmod|system system|nmod|END_ENTITY	The influence of fibrinogen and fibrin on thrombin generation -- evidence for feedback activation of the clotting system by clot bound thrombin .
7900079	0	fibrinogen	17,27	thrombin	42,50	fibrinogen	thrombin	2244	2147	Gene	Gene	influence|nmod|START_ENTITY influence|nmod|generation generation|compound|END_ENTITY	The influence of fibrinogen and fibrin on thrombin generation -- evidence for feedback activation of the clotting system by clot bound thrombin .
7967434	0	fibrinogen	37,47	thrombin	10,18	fibrinogen	thrombin	2244	2147	Gene	Gene	recovery|compound|START_ENTITY generation|nmod|recovery generation|compound|END_ENTITY	Increased thrombin generation during fibrinogen and platelet recovery as an explanation for hypercoagulability in children with L-asparaginase therapy for ALL or NHL : a preliminary report .
8091386	0	fibrinogen	89,99	thrombin	40,48	fibrinogen	thrombin	2244	2147	Gene	Gene	role|nmod|START_ENTITY insights|nmod|role levels|dep|insights levels|nmod|marker marker|nmod|activation activation|compound|END_ENTITY	Fibrinogen plasma levels as a marker of thrombin activation : new insights on the role of fibrinogen as a cardiovascular_risk factor .
8362369	0	fibrinogen	61,71	thrombin	86,94	fibrinogen	thrombin	2244	2147	Gene	Gene	E|amod|START_ENTITY cleavage|nmod|E cleavage|nmod|END_ENTITY	Comparison of the sequence of fibrinopeptide A cleavage from fibrinogen fragment E by thrombin , atroxin , or batroxobin .
8364489	0	fibrinogen	15,25	thrombin	85,93	fibrinogen	thrombin	2244	2147	Gene	Gene	Sialic_acid|nmod|START_ENTITY Sialic_acid|dep|effects effects|nmod|sialic_acid sialic_acid|nmod|conversion conversion|nmod|END_ENTITY	Sialic_acid in fibrinogen : effects of sialic_acid on fibrinogen-fibrin conversion by thrombin and properties of asialofibrin clot .
8652575	0	fibrinogen	55,65	thrombin	91,99	fibrinogen	thrombin	2244	2147	Gene	Gene	variants|amod|START_ENTITY variants|nmod|substrates substrates|compound|END_ENTITY	Strategy for recombinant multichain protein synthesis : fibrinogen B beta-chain variants as thrombin substrates .
8662661	0	fibrinogen	54,64	thrombin	31,39	fibrinogen	thrombin	2244	2147	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Transient intermediates in the thrombin activation of fibrinogen .
8703074	0	fibrinogen	48,58	thrombin	73,81	fibrinogen	thrombin	2244	2147	Gene	Gene	activation|nmod|START_ENTITY cleavage|nsubj|activation cleavage|nmod|modulator modulator|compound|END_ENTITY	Enhanced protein C activation and inhibition of fibrinogen cleavage by a thrombin modulator .
8865525	0	fibrinogen	110,120	thrombin	20,28	fibrinogen	thrombin	2244	2147	Gene	Gene	influencing|dobj|START_ENTITY reduces|advcl|influencing reduces|dobj|generation generation|compound|END_ENTITY	Gemfibrozil reduces thrombin generation in patients with combined_hyperlipidaemia , without influencing plasma fibrinogen , fibrin gel structure or coagulation_factor_VII .
89993	0	fibrinogen	48,58	thrombin	14,22	fibrinogen	thrombin	2244	2147	Gene	Gene	aggregates|compound|START_ENTITY count|nsubj|aggregates increased|ccomp|count increased|nsubj|END_ENTITY	Short heparin thrombin clotting time , increased fibrinogen and platelet aggregates count in coronary_disease : a probable hypercoagulable state .
9175247	0	fibrinogen	44,54	thrombin	69,77	fibrinogen	thrombin	2244	2147	Gene	Gene	release|nmod|START_ENTITY related|nsubjpass|release related|xcomp|END_ENTITY	Fibrinopeptide_A release from intraplatelet fibrinogen is related to thrombin platelet activation .
9242618	0	fibrinogen	18,28	thrombin	53,61	fibrinogen	thrombin	2244	2147	Gene	Gene	loss|nmod|START_ENTITY loss|acl|clotting clotting|nmod|END_ENTITY	Selective loss of fibrinogen clotting in a loop-less thrombin .
9401064	0	fibrinogen	87,97	thrombin	14,22	fibrinogen	thrombin	2244	2147	Gene	Gene	exchange|nmod|START_ENTITY effect|nmod|exchange effect|nmod|END_ENTITY	The effect of thrombin on the dynamic exchange between intraplatelet and extraplatelet fibrinogen .
9753458	0	fibrinogen	130,140	thrombin	87,95	fibrinogen	thrombin	2244	2147	Gene	Gene	fibrinopeptide|nmod|START_ENTITY fibrinopeptide|nmod|cleavage cleavage|compound|END_ENTITY	Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen .
2822406	0	fibrinogen	48,58	thrombomodulin	14,28	fibrinogen	thrombomodulin	2244	7056	Gene	Gene	cleavage|nmod|START_ENTITY END_ENTITY|nmod|cleavage	The effect of thrombomodulin on the cleavage of fibrinogen and fibrinogen fragments by thrombin .
2107597	0	fibrinogen	15,25	tissue_plasminogen_activator	29,57	fibrinogen	tissue plasminogen activator	2244	100128998	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of fibrinogen by tissue_plasminogen_activator .
24293368	0	fibrinogen_C_domain_containing_1	74,106	FIBCD1	108,114	fibrinogen C domain containing 1	FIBCD1	84929	84929	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Crystal structure of the tetrameric fibrinogen-like recognition domain of fibrinogen_C_domain_containing_1 -LRB- FIBCD1 -RRB- protein .
17445871	0	fibrinogen_gamma	4,20	FGG	22,25	fibrinogen gamma	FGG	2266	2266	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	The fibrinogen_gamma -LRB- FGG -RRB- 10034C > T polymorphism is associated with venous_thrombosis .
15025951	0	fibrinogen_gamma_polypeptide	31,59	FGG	61,64	fibrinogen gamma polypeptide	FGG	2266	2266	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Cloning and identification of fibrinogen_gamma_polypeptide -LRB- FGG -RRB- gene differentially expressed in human hepatocellular_carcinoma -RSB- .
9677325	0	fibroblast-growth-factor-inducible_kinase	34,75	Fnk	77,80	fibroblast-growth-factor-inducible kinase	Fnk	1263	1263	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and phosphorylation of fibroblast-growth-factor-inducible_kinase -LRB- Fnk -RRB- during cell-cycle progression .
26621486	0	fibroblast_activation_protein	47,76	Neuropeptide_Y	0,14	fibroblast activation protein	Neuropeptide Y	2191	4852	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Neuropeptide_Y is a physiological substrate of fibroblast_activation_protein : Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver_cirrhosis and hepatocellular_carcinoma .
19747910	0	fibroblast_activation_protein	17,46	TGF-beta	0,8	fibroblast activation protein	TGF-beta	2191	7040	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-beta induces fibroblast_activation_protein expression ; fibroblast_activation_protein expression increases the proliferation , adhesion , and migration of HO-8910PM -LSB- corrected -RSB- .
19747910	0	fibroblast_activation_protein	59,88	TGF-beta	0,8	fibroblast activation protein	TGF-beta	2191	7040	Gene	Gene	expression|compound|START_ENTITY increases|nsubj|expression induces|parataxis|increases induces|nsubj|END_ENTITY	TGF-beta induces fibroblast_activation_protein expression ; fibroblast_activation_protein expression increases the proliferation , adhesion , and migration of HO-8910PM -LSB- corrected -RSB- .
11241314	0	fibroblast_activation_protein	22,51	seprase	52,59	fibroblast activation protein	seprase	2191	2191	Gene	Gene	expression|nmod|START_ENTITY expression|parataxis|associated associated|nsubjpass|END_ENTITY	Stromal expression of fibroblast_activation_protein / seprase , a cell membrane serine proteinase and gelatinase , is associated with longer survival in patients with invasive_ductal_carcinoma of breast .
8776762	0	fibroblast_collagenase	37,59	MMP-1	61,66	fibroblast collagenase	MMP-1	4312	4312	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and purification of human fibroblast_collagenase -LRB- MMP-1 -RRB- expressed in the methylotrophic yeast Pichia_pastoris .
12058341	0	fibroblast_growth_factor	17,41	FGF-2	43,48	fibroblast growth factor	FGF-2	2247	2247	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- on proliferation of human skin fibroblasts in type_II_diabetes_mellitus .
7898570	0	fibroblast_growth_factor	26,50	FGF-2	52,57	fibroblast growth factor	FGF-2	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	The localization of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- in rat submandibular glands .
8072023	0	fibroblast_growth_factor	41,65	FGF-2	67,72	fibroblast growth factor	FGF-2	403857(Tax:9615)	403857(Tax:9615)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Longitudinal changes in myocardial basic fibroblast_growth_factor -LRB- FGF-2 -RRB- activity following coronary artery ligation in the dog .
8397111	0	fibroblast_growth_factor	25,49	FGF-2	51,56	fibroblast growth factor	FGF-2	2247	2247	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- in the nuclei of SK-Hep-1 cells .
9293890	0	fibroblast_growth_factor	20,44	FGF-2	46,51	fibroblast growth factor	FGF-2	2247	2247	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of basic fibroblast_growth_factor -LRB- FGF-2 -RRB- - associated with tumour proliferation in human pancreatic_carcinoma .
19586755	0	fibroblast_growth_factor	16,40	FGF2	42,46	fibroblast growth factor	FGF2	2247	2247	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effect of basic fibroblast_growth_factor -LRB- FGF2 -RRB- gene polymorphisms on SSRIs treatment response and side effects .
10929227	0	fibroblast_growth_factor-1	11,37	FGF-1	39,44	fibroblast growth factor-1	FGF-1	2246	2246	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- on spiral_ganglion cells of the mammalian cochlea -RSB- .
11690635	0	fibroblast_growth_factor-1	54,80	FGF-1	82,87	fibroblast growth factor-1	FGF-1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Cloning and characterization of a novel form of mouse fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- mRNA , FGF-1 .
11690635	0	fibroblast_growth_factor-1	54,80	FGF-1	95,100	fibroblast growth factor-1	FGF-1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Cloning and characterization of a novel form of mouse fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- mRNA , FGF-1 .
1375939	0	fibroblast_growth_factor-1	22,48	FGF-1	50,55	fibroblast growth factor-1	FGF-1	2246	2246	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Inactivation of human fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- activity by interaction with copper_ions involves FGF-1 dimer formation induced by copper-catalyzed oxidation .
9021547	0	fibroblast_growth_factor-1	36,62	FGFR-1	119,125	fibroblast growth factor-1	FGFR-1	2246	2260	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of fibroblast_growth_factor-1 -LRB- FGF-1 -RRB- , FGF-2 and fibroblast_growth_factor_receptor-1 -LRB- FGFR-1 -RRB- in pleomorphic_adenoma of the salivary glands .
9712836	0	fibroblast_growth_factor-1	41,67	synaptotagmin-1	76,91	fibroblast growth factor-1	synaptotagmin-1	14164(Tax:10090)	20979(Tax:10090)	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	S100A13 is involved in the regulation of fibroblast_growth_factor-1 and p40 synaptotagmin-1 release in vitro .
15140207	0	fibroblast_growth_factor-13	46,73	FHF-2	75,80	fibroblast growth factor-13	FHF-2	14168(Tax:10090)	14168(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Bulge - and basal layer-specific expression of fibroblast_growth_factor-13 -LRB- FHF-2 -RRB- in mouse skin .
15777655	0	fibroblast_growth_factor-2	9,35	BMP-2	83,88	fibroblast growth factor-2	BMP-2	14173(Tax:10090)	12156(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Low dose fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- enhances bone_morphogenetic_protein-2 -LRB- BMP-2 -RRB- - induced ectopic bone formation in mice .
11075807	0	fibroblast_growth_factor-2	5,31	FGF-2	132,137	fibroblast growth factor-2	FGF-2	2247	2247	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	FIF -LSB- fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- - interacting-factor -RSB- , a nuclear putatively antiapoptotic factor , interacts specifically with FGF-2 .
15875782	0	fibroblast_growth_factor-2	65,91	FGF-2	93,98	fibroblast growth factor-2	FGF-2	2247	2247	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Influence of hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- on fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- levels in external auditory canal cholesteatoma -LRB- EACC -RRB- cell culture .
15957346	0	fibroblast_growth_factor-2	22,48	FGF-2	50,55	fibroblast growth factor-2	FGF-2	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- during embryonic development of the rat submandibular gland .
8714368	0	fibroblast_growth_factor-2	12,38	FGF-2	40,45	fibroblast growth factor-2	FGF-2	2247	2247	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- in hematopoiesis .
9582440	0	fibroblast_growth_factor-2	90,116	FGF-2	118,123	fibroblast growth factor-2	FGF-2	281161(Tax:9913)	281161(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Increased tyrosine phosphorylation and novel cis-acting element mediate activation of the fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- gene by nicotinic acetylcholine receptor .
8756003	0	fibroblast_growth_factor-2	69,95	Heparin-binding_epidermal_growth_factor-like_growth_factor	0,58	fibroblast growth factor-2	Heparin-binding epidermal growth factor-like growth factor	2247	1839	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Heparin-binding_epidermal_growth_factor-like_growth_factor regulates fibroblast_growth_factor-2 expression in aortic smooth_muscle_cells .
21143527	0	fibroblast_growth_factor-2	23,49	TRX	0,3	fibroblast growth factor-2	TRX	2247	7295	Gene	Gene	up-regulated|advcl|START_ENTITY up-regulated|nsubj|END_ENTITY	TRX is up-regulated by fibroblast_growth_factor-2 in lung_carcinoma .
14572781	0	fibroblast_growth_factor-2	96,122	Vascular_endothelial_growth_factor	0,34	fibroblast growth factor-2	Vascular endothelial growth factor	2247	7422	Gene	Gene	augmented|nmod|START_ENTITY augmented|nsubjpass|synthesis synthesis|compound|END_ENTITY	Vascular_endothelial_growth_factor synthesis by human omental mesothelial cells is augmented by fibroblast_growth_factor-2 : possible role of mesothelial cell on the development of peritoneal metastasis .
18164591	0	fibroblast_growth_factor-2	136,162	Vascular_endothelial_growth_factor	0,34	fibroblast growth factor-2	Vascular endothelial growth factor	2247	7422	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast_growth_factor-2 .
9400373	0	fibroblast_growth_factor-2	71,97	Vascular_endothelial_growth_factor	0,34	fibroblast growth factor-2	Vascular endothelial growth factor	54250(Tax:10116)	83785(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY increases|nmod|cells increases|nsubj|END_ENTITY	Vascular_endothelial_growth_factor increases the mitogenic response to fibroblast_growth_factor-2 in vascular smooth muscle cells in vivo via expression of fms-like_tyrosine_kinase-1 .
12221014	0	fibroblast_growth_factor-2	14,40	bone_morphogenetic_protein-2	93,121	fibroblast growth factor-2	bone morphogenetic protein-2	2247	650	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	The effect of fibroblast_growth_factor-2 on the osteoinductive activity of recombinant human bone_morphogenetic_protein-2 in rat muscle .
14684627	0	fibroblast_growth_factor-2	56,82	extracellular_signal-regulated_kinases_1_and_2	97,143	fibroblast growth factor-2	extracellular signal-regulated kinases 1 and 2	2247	5594	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Heparan sulfate proteoglycans function as receptors for fibroblast_growth_factor-2 activation of extracellular_signal-regulated_kinases_1_and_2 .
10229675	0	fibroblast_growth_factor-2	71,97	interleukin-6	14,27	fibroblast growth factor-2	interleukin-6	2247	3569	Gene	Gene	cells|amod|START_ENTITY Inhibition|nmod|cells Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of interleukin-6 promoter activity by the 24 kDa isoform of fibroblast_growth_factor-2 in HeLa cells .
11102571	0	fibroblast_growth_factor-2	112,138	interleukin-6	14,27	fibroblast growth factor-2	interleukin-6	54250(Tax:10116)	24498(Tax:10116)	Gene	Gene	relation|nmod|START_ENTITY Expression|dep|relation Expression|nmod|END_ENTITY	Expression of interleukin-6 and its receptor in the sciatic nerve and cultured Schwann cells : relation to 18-kD fibroblast_growth_factor-2 .
12414666	0	fibroblast_growth_factor-2	75,101	latent_membrane_protein_1	19,44	fibroblast growth factor-2	latent membrane protein 1	2247	9260	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Epstein-barr_virus latent_membrane_protein_1 induces and causes release of fibroblast_growth_factor-2 .
10830293	0	fibroblast_growth_factor-2	14,40	vascular_endothelial_growth_factor	55,89	fibroblast growth factor-2	vascular endothelial growth factor	14173(Tax:10090)	22339(Tax:10090)	Gene	Gene	modulation|amod|START_ENTITY Mechanisms|nmod|modulation Mechanisms|nmod|expression expression|compound|END_ENTITY	Mechanisms of fibroblast_growth_factor-2 modulation of vascular_endothelial_growth_factor expression by osteoblastic cells .
23873427	0	fibroblast_growth_factor-21	18,45	FGF-21	47,53	fibroblast growth factor-21	FGF-21	26291	26291	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes of plasma fibroblast_growth_factor-21 -LRB- FGF-21 -RRB- in oral glucose tolerance test and effects of metformin on FGF-21 levels in type_2_diabetes_mellitus .
20813767	0	fibroblast_growth_factor-23	6,33	FGF-23	35,41	fibroblast growth factor-23	FGF-23	8074	8074	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum fibroblast_growth_factor-23 -LRB- FGF-23 -RRB- levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients .
22933546	0	fibroblast_growth_factor-23	23,50	FGF23	52,57	fibroblast growth factor-23	FGF23	8074	8074	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Frequent expression of fibroblast_growth_factor-23 -LRB- FGF23 -RRB- mRNA in aneurysmal_bone_cysts and chondromyxoid_fibromas .
17970775	0	fibroblast_growth_factor-23	24,51	fetuin-A	59,67	fibroblast growth factor-23	fetuin-A	8074	197	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Relation between plasma fibroblast_growth_factor-23 , serum fetuin-A levels and coronary_artery_calcification evaluated by multislice computed tomography in patients with normal kidney function .
16436388	0	fibroblast_growth_factor-23	14,41	klotho	55,61	fibroblast growth factor-23	klotho	64654(Tax:10090)	16591(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of fibroblast_growth_factor-23 signaling by klotho .
25196492	0	fibroblast_growth_factor-23	16,43	matrix_gla_protein	45,63	fibroblast growth factor-23	matrix gla protein	8074	4256	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of serum fibroblast_growth_factor-23 , matrix_gla_protein and fetuin-a in predicting osteoporosis in maintenance_hemodialysis patients .
7593222	0	fibroblast_growth_factor-4	127,153	Fibroblast_growth_factor_receptors_1_and_2	0,42	fibroblast growth factor-4	Fibroblast growth factor receptors 1 and 2	14175(Tax:10090)	14182;14183	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Fibroblast_growth_factor_receptors_1_and_2 are differentially regulated in murine embryonal_carcinoma cells and in response to fibroblast_growth_factor-4 .
16174451	0	fibroblast_growth_factor-4	130,156	hepatocyte_growth_factor	100,124	fibroblast growth factor-4	hepatocyte growth factor	2249	3082	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Human bone marrow multipotent adult progenitor cells differentiate into hepatocyte-like cells with hepatocyte_growth_factor plus fibroblast_growth_factor-4 in vitro -RSB- .
8608216	0	fibroblast_growth_factor-4	11,37	k-FGF	39,44	fibroblast growth factor-4	k-FGF	2249	2249	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of fibroblast_growth_factor-4 -LRB- k-FGF -RRB- on long-term cultures of human bone marrow cells .
15307144	0	fibroblast_growth_factor-7	41,67	keratinocyte_growth_factor	14,40	fibroblast growth factor-7	keratinocyte growth factor	2252	2252	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of keratinocyte_growth_factor / fibroblast_growth_factor-7 and its receptor in human lung_cancer : correlation with tumour proliferative activity and patient prognosis .
10842056	0	fibroblast_growth_factor-8	22,48	FGF-8	50,55	fibroblast growth factor-8	FGF-8	396313(Tax:9031)	396313(Tax:9031)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Multiple functions of fibroblast_growth_factor-8 -LRB- FGF-8 -RRB- in chick eye development .
16412577	0	fibroblast_growth_factor-binding_protein	51,91	FGF-BP	93,99	fibroblast growth factor-binding protein	FGF-BP	281812(Tax:9913)	281812(Tax:9913)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Purification and biochemical characterization of a fibroblast_growth_factor-binding_protein -LRB- FGF-BP -RRB- from the lactoferrin fraction of bovine milk .
14678957	0	fibroblast_growth_factor-binding_protein	17,57	beta-catenin	62,74	fibroblast growth factor-binding protein	beta-catenin	9982	1499	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of fibroblast_growth_factor-binding_protein , by beta-catenin during colon carcinogenesis .
10207015	0	fibroblast_growth_factor_1	63,89	FGF-1	91,96	fibroblast growth factor 1	FGF-1	14164(Tax:10090)	14164(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the entire transcription unit of the mouse fibroblast_growth_factor_1 -LRB- FGF-1 -RRB- gene .
19410332	0	fibroblast_growth_factor_10	23,50	FGF-10	52,58	fibroblast growth factor 10	FGF-10	14165(Tax:10090)	14165(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Negative regulation of fibroblast_growth_factor_10 -LRB- FGF-10 -RRB- by polyoma_enhancer_activator_3 -LRB- PEA3 -RRB- .
17682060	0	fibroblast_growth_factor_10	77,104	FGF_receptor_2	113,127	fibroblast growth factor 10	FGF receptor 2	2255	2263	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Lacrimo-auriculo-dento-digital_syndrome is caused by reduced activity of the fibroblast_growth_factor_10 -LRB- FGF10 -RRB- - FGF_receptor_2 signaling pathway .
22719891	0	fibroblast_growth_factor_10	28,55	Fgf10	57,62	fibroblast growth factor 10	Fgf10	14165(Tax:10090)	14165(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Characterization of a novel fibroblast_growth_factor_10 -LRB- Fgf10 -RRB- knock-in mouse line to target mesenchymal progenitors during embryonic development .
19410332	0	fibroblast_growth_factor_10	23,50	polyoma_enhancer_activator_3	63,91	fibroblast growth factor 10	polyoma enhancer activator 3	14165(Tax:10090)	18612(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of fibroblast_growth_factor_10 -LRB- FGF-10 -RRB- by polyoma_enhancer_activator_3 -LRB- PEA3 -RRB- .
16211615	0	fibroblast_growth_factor_14	57,84	SCA27	91,96	fibroblast growth factor 14	SCA27	2259	2259	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Spinocerebellar_ataxia associated with a mutation in the fibroblast_growth_factor_14 gene -LRB- SCA27 -RRB- : A new phenotype .
24248542	0	fibroblast_growth_factor_19	5,32	FGF19	34,39	fibroblast growth factor 19	FGF19	9965	9965	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	High fibroblast_growth_factor_19 -LRB- FGF19 -RRB- expression predicts worse prognosis in invasive_ductal_carcinoma of breast .
16905765	0	fibroblast_growth_factor_2	48,74	E-series_prostanoid-2	126,147	fibroblast growth factor 2	E-series prostanoid-2	2247	5732	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Seminal plasma and prostaglandin_E2 up-regulate fibroblast_growth_factor_2 expression in endometrial_adenocarcinoma cells via E-series_prostanoid-2 receptor-mediated transactivation of the epidermal_growth_factor_receptor and extracellular_signal-regulated_kinase pathway .
10809367	0	fibroblast_growth_factor_2	25,51	FGF-2	53,58	fibroblast growth factor 2	FGF-2	2247	2247	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cellular localization of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- in benign_prostatic_hyperplasia .
16412094	0	fibroblast_growth_factor_2	22,48	FGF-2	50,55	fibroblast growth factor 2	FGF-2	54250(Tax:10116)	54250(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Dynamic regulation of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- gene expression in the rat brain following single and repeated cocaine administration .
20581332	0	fibroblast_growth_factor_2	28,54	FGF-2	56,61	fibroblast growth factor 2	FGF-2	2247	2247	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and functions of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- in hippocampal formation .
9558385	0	fibroblast_growth_factor_2	28,54	FGF-2	56,61	fibroblast growth factor 2	FGF-2	14173(Tax:10090)	14173(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Platelet_factor_4 modulates fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- activity and inhibits FGF-2 dimerization .
9681690	0	fibroblast_growth_factor_2	16,42	FGF-2	44,49	fibroblast growth factor 2	FGF-2	2247	2247	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Localization of fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- protein and the receptors FGFR_1-4 in normal human seminiferous epithelium .
18487671	0	fibroblast_growth_factor_2	22,48	FGF2	50,54	fibroblast growth factor 2	FGF2	281161(Tax:9913)	281161(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of bovine fibroblast_growth_factor_2 -LRB- FGF2 -RRB- gene with milk fat and productive life : an example of the ability of the candidate pathway strategy to identify quantitative trait genes .
26811540	0	fibroblast_growth_factor_2	23,49	Interleukin-1b	0,14	fibroblast growth factor 2	Interleukin-1b	14173(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1b induces fibroblast_growth_factor_2 expression and subsequently promotes endothelial progenitor cell angiogenesis in chondrocytes .
9558385	0	fibroblast_growth_factor_2	28,54	Platelet_factor_4	0,17	fibroblast growth factor 2	Platelet factor 4	14173(Tax:10090)	56744(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Platelet_factor_4 modulates fibroblast_growth_factor_2 -LRB- FGF-2 -RRB- activity and inhibits FGF-2 dimerization .
12543640	0	fibroblast_growth_factor_2	27,53	Syndecan-4	0,10	fibroblast growth factor 2	Syndecan-4	14173(Tax:10090)	20971(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Syndecan-4 modulates basic fibroblast_growth_factor_2 signaling in vivo .
27007053	0	fibroblast_growth_factor_2	39,65	bFGF	73,77	fibroblast growth factor 2	bFGF	2247	2247	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Molecular and clinical significance of fibroblast_growth_factor_2 -LRB- FGF2 / bFGF -RRB- in malignancies_of_solid_and_hematological_cancers for personalized therapies .
23485603	0	fibroblast_growth_factor_2	66,92	bone_sialoprotein	40,57	fibroblast growth factor 2	bone sialoprotein	2247	3381	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the human bone_sialoprotein gene by fibroblast_growth_factor_2 .
26655091	0	fibroblast_growth_factor_2	15,41	miR-16	0,6	fibroblast growth factor 2	miR-16	2247	51573	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-16 targets fibroblast_growth_factor_2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways .
11313915	0	fibroblast_growth_factor_2	37,63	p53	18,21	fibroblast growth factor 2	p53	2247	7157	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Tumour suppressor p53 inhibits human fibroblast_growth_factor_2 expression by a post-transcriptional mechanism .
26727404	0	fibroblast_growth_factor_2	88,114	stem_cell_factor	8,24	fibroblast growth factor 2	stem cell factor	396413(Tax:9031)	396028(Tax:9031)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Chicken stem_cell_factor enhances primordial germ cell proliferation cooperatively with fibroblast_growth_factor_2 .
17284717	0	fibroblast_growth_factor_2	10,36	stromal_cell-derived_factor_1	40,69	fibroblast growth factor 2	stromal cell-derived factor 1	14173(Tax:10090)	20315(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of fibroblast_growth_factor_2 on stromal_cell-derived_factor_1 production by bone marrow stromal cells and hematopoiesis .
18753452	0	fibroblast_growth_factor_2	14,40	syndecan-4	71,81	fibroblast growth factor 2	syndecan-4	100550388	100126249(Tax:9103)	Gene	Gene	START_ENTITY|nmod|expression expression|acl|END_ENTITY	The effect of fibroblast_growth_factor_2 on the in vitro expression of syndecan-4 and glypican-1 in turkey satellite cells .
23772770	0	fibroblast_growth_factor_2	43,69	syndecan-4	103,113	fibroblast growth factor 2	syndecan-4	100550388	100126249(Tax:9103)	Gene	Gene	responsiveness|amod|START_ENTITY Changes|nmod|responsiveness Changes|nmod|age age|amod|END_ENTITY	Changes in proliferation , differentiation , fibroblast_growth_factor_2 responsiveness and expression of syndecan-4 and glypican-1 with turkey satellite cell age .
11874241	0	fibroblast_growth_factor_2	14,40	transforming_growth_factor_beta	83,114	fibroblast growth factor 2	transforming growth factor beta	2247	7040	Gene	Gene	receptors|amod|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of fibroblast_growth_factor_2 and fibroblast growth factor receptors by transforming_growth_factor_beta in human osteoblastic MG-63 cells .
9053843	0	fibroblast_growth_factor_2	101,127	vascular_endothelial_growth_factor	18,52	fibroblast growth factor 2	vascular endothelial growth factor	54250(Tax:10116)	83785(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of vascular_endothelial_growth_factor induces cell transformation in cooperation with fibroblast_growth_factor_2 .
9305872	0	fibroblast_growth_factor_2	26,52	vascular_endothelial_growth_factor	83,117	fibroblast growth factor 2	vascular endothelial growth factor	2247	7422	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Cell release of bioactive fibroblast_growth_factor_2 by exon 6-encoded sequence of vascular_endothelial_growth_factor .
27085971	0	fibroblast_growth_factor_21	15,42	BMP-9	0,5	fibroblast growth factor 21	BMP-9	26291	2658	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	BMP-9 enhances fibroblast_growth_factor_21 expression and suppresses obesity .
17452648	0	fibroblast_growth_factor_21	49,76	BetaKlotho	0,10	fibroblast growth factor 21	BetaKlotho	56636(Tax:10090)	83379(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	BetaKlotho is required for metabolic activity of fibroblast_growth_factor_21 .
19531026	0	fibroblast_growth_factor_21	12,39	FGF21	41,46	fibroblast growth factor 21	FGF21	56636(Tax:10090)	56636(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of fibroblast_growth_factor_21 -LRB- FGF21 -RRB- on energy balance , glucose and lipid metabolism .
22374976	0	fibroblast_growth_factor_21	8,35	FGF21	37,42	fibroblast growth factor 21	FGF21	56636(Tax:10090)	56636(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of fibroblast_growth_factor_21 -LRB- FGF21 -RRB- in undernutrition-related attenuation of growth in mice .
22701542	0	fibroblast_growth_factor_21	25,52	FGF21	54,59	fibroblast growth factor 21	FGF21	26291	26291	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Exercise increases serum fibroblast_growth_factor_21 -LRB- FGF21 -RRB- levels .
25270507	0	fibroblast_growth_factor_21	13,40	Nrf2	0,4	fibroblast growth factor 21	Nrf2	56636(Tax:10090)	18024(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Nrf2 induces fibroblast_growth_factor_21 in diabetic mice .
17550778	0	fibroblast_growth_factor_21	8,35	PPARalpha	52,61	fibroblast growth factor 21	PPARalpha	56636(Tax:10090)	19013(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Hepatic fibroblast_growth_factor_21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states .
27083047	0	fibroblast_growth_factor_22	11,38	insulin-like_growth_factor_2	67,95	fibroblast growth factor 22	insulin-like growth factor 2	27006	3481	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Retrograde fibroblast_growth_factor_22 -LRB- FGF22 -RRB- signaling regulates insulin-like_growth_factor_2 -LRB- IGF2 -RRB- expression for activity-dependent synapse stabilization in the mammalian brain .
16751688	2	fibroblast_growth_factor_23	120,147	FGF-23	149,155	fibroblast growth factor 23	FGF-23	8074	8074	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	The measurement of circulating fibroblast_growth_factor_23 -LRB- FGF-23 -RRB- -RSB- .
19483276	1	fibroblast_growth_factor_23	99,126	FGF23	128,133	fibroblast growth factor 23	FGF23	8074	8074	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Clinical usefulness of measurement of fibroblast_growth_factor_23 -LRB- FGF23 -RRB- -RSB- .
23146451	0	fibroblast_growth_factor_23	8,35	FGF23	37,42	fibroblast growth factor 23	FGF23	8074	8074	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of fibroblast_growth_factor_23 -LRB- FGF23 -RRB- in the metabolism of phosphorus and calcium immediately after kidney transplantation .
25700720	0	fibroblast_growth_factor_23	12,39	FGF23	41,46	fibroblast growth factor 23	FGF23	8074	8074	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating fibroblast_growth_factor_23 -LRB- FGF23 -RRB- levels are associated with metabolic disturbances and fat distribution but not cardiovascular risk in HIV-infected patients .
25113414	0	fibroblast_growth_factor_23	43,70	Klotho	105,111	fibroblast growth factor 23	Klotho	8074	9365	Gene	Gene	START_ENTITY|acl|accompanied accompanied|advcl|increasing increasing|dobj|levels levels|compound|END_ENTITY	Long-term sevelamer treatment lowers serum fibroblast_growth_factor_23 accompanied with increasing serum Klotho levels in chronic haemodialysis patients .
26069066	0	fibroblast_growth_factor_23	11,38	Klotho	47,53	fibroblast growth factor 23	Klotho	8074	9365	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	The couple fibroblast_growth_factor_23 -LRB- FGF23 -RRB- / Klotho .
20200981	0	fibroblast_growth_factor_23	18,45	Leptin	0,6	fibroblast growth factor 23	Leptin	64654(Tax:10090)	16846(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Leptin stimulates fibroblast_growth_factor_23 expression in bone and suppresses renal 1alpha,25-dihydroxyvitamin _ D3 synthesis in leptin-deficient mice .
21544372	0	fibroblast_growth_factor_4	18,44	FGF-4	46,51	fibroblast growth factor 4	FGF-4	2249	2249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the fibroblast_growth_factor_4 -LRB- FGF-4 -RRB- gene is regulated by serum in Tera-2 embryonal_carcinoma cells .
8199350	0	fibroblast_growth_factor_6	20,46	FGF6	48,52	fibroblast growth factor 6	FGF6	14177(Tax:10090)	14177(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	The human and mouse fibroblast_growth_factor_6 -LRB- FGF6 -RRB- genes and their products : possible implication in muscle development .
9878802	0	fibroblast_growth_factor_6	20,46	FGF6	48,52	fibroblast growth factor 6	FGF6	2251	2251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a fibroblast_growth_factor_6 -LRB- FGF6 -RRB- gene in a non-mammalian vertebrate : continuous expression of FGF6 accompanies muscle fiber hyperplasia .
18386288	0	fibroblast_growth_factor_7	42,68	Protease-activated_receptor-1	0,29	fibroblast growth factor 7	Protease-activated receptor-1	2252	2149	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Protease-activated_receptor-1 upregulates fibroblast_growth_factor_7 in stroma of benign_prostatic_hyperplasia .
23592779	0	fibroblast_growth_factor_8	38,64	Cubilin	0,7	fibroblast growth factor 8	Cubilin	14179(Tax:10090)	65969(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Cubilin , a high affinity receptor for fibroblast_growth_factor_8 , is required for cell survival in the developing vertebrate head .
18699993	0	fibroblast_growth_factor_8	8,34	FGF8	36,40	fibroblast growth factor 8	FGF8	29349(Tax:10116)	29349(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of fibroblast_growth_factor_8 -LRB- FGF8 -RRB- in animal models of osteoarthritis .
22798350	0	fibroblast_growth_factor_9	11,37	FGF9	39,43	fibroblast growth factor 9	FGF9	613731(Tax:9913)	613731(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of fibroblast_growth_factor_9 -LRB- FGF9 -RRB- on steroidogenesis and gene expression and control of FGF9 mRNA in bovine granulosa cells .
17439743	0	fibroblast_growth_factor_9	10,36	Runx2	40,45	fibroblast growth factor 9	Runx2	14180(Tax:10090)	12393(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of fibroblast_growth_factor_9 on Runx2 gene promoter activity in MC3T3-E1 and C2C12 cells .
15929978	0	fibroblast_growth_factor_receptor-1	53,88	CREB-binding_protein	11,31	fibroblast growth factor receptor-1	CREB-binding protein	2260	1387	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Control of CREB-binding_protein signaling by nuclear fibroblast_growth_factor_receptor-1 : a novel mechanism of gene regulation .
19285023	0	fibroblast_growth_factor_receptor-1	50,85	Related_transcriptional_enhancer_factor-1	0,41	fibroblast growth factor receptor-1	Related transcriptional enhancer factor-1	14182(Tax:10090)	21679(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Related_transcriptional_enhancer_factor-1 induces fibroblast_growth_factor_receptor-1 expression in endothelial cells .
9480847	0	fibroblast_growth_factor_receptor-1	43,78	Shc	21,24	fibroblast growth factor receptor-1	Shc	14182(Tax:10090)	20416(Tax:10090)	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Novel recruitment of Shc , Grb2 , and Sos by fibroblast_growth_factor_receptor-1 in v-Src-transformed cells .
8764646	0	fibroblast_growth_factor_receptor-1	4,39	aFGF	109,113	fibroblast growth factor receptor-1	aFGF	79114(Tax:10116)	25317(Tax:10116)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	The fibroblast_growth_factor_receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF .
10739663	0	fibroblast_growth_factor_receptor-2	14,49	FGFR-2	51,57	fibroblast growth factor receptor-2	FGFR-2	2263	2263	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	The Ser252Trp fibroblast_growth_factor_receptor-2 -LRB- FGFR-2 -RRB- mutation induces PKC-independent downregulation of FGFR-2 associated with premature calvaria osteoblast differentiation .
12960068	0	fibroblast_growth_factor_receptor-3	14,49	FGFR3	208,213	fibroblast growth factor receptor-3	FGFR3	84489(Tax:10116)	84489(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of fibroblast_growth_factor_receptor-3 -LRB- FGFR3 -RRB- , signal_transducer_and_activator_of_transcription-1 , and cyclin-dependent kinase inhibitor p21 during endochondral ossification : differential role of FGFR3 in skeletal development and fracture repair .
21044961	0	fibroblast_growth_factor_receptor-like_1	67,107	MicroRNA-210	0,12	fibroblast growth factor receptor-like 1	MicroRNA-210	53834	406992	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast_growth_factor_receptor-like_1 -LRB- FGFRL1 -RRB- .
15548653	0	fibroblast_growth_factor_receptor_1	20,55	Anosmin-1	0,9	fibroblast growth factor receptor 1	Anosmin-1	2260	3730	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Anosmin-1 modulates fibroblast_growth_factor_receptor_1 signaling in human gonadotropin-releasing_hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism .
19303924	0	fibroblast_growth_factor_receptor_1	36,71	E2F-1	75,80	fibroblast growth factor receptor 1	E2F-1	2260	1869	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of human fibroblast_growth_factor_receptor_1 by E2F-1 .
1437152	0	fibroblast_growth_factor_receptor_1	18,53	FGFR-1	55,61	fibroblast growth factor receptor 1	FGFR-1	2260	2260	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inhibition of the fibroblast_growth_factor_receptor_1 -LRB- FGFR-1 -RRB- gene in human melanocytes and malignant_melanomas leads to inhibition of proliferation and signs indicative of differentiation .
26557159	0	fibroblast_growth_factor_receptor_1	28,63	FGFR1	65,70	fibroblast growth factor receptor 1	FGFR1	2260	2260	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutation detection of fibroblast_growth_factor_receptor_1 -LRB- FGFR1 -RRB- gene , FGFR2IIIa , FGFR2IIIb , FGFR2IIIc , FGFR3 , FGFR4 gene for craniosynostosis : A prospective study in Asian Indian patient .
9949182	0	fibroblast_growth_factor_receptor_1	105,140	FOP	97,100	fibroblast growth factor receptor 1	FOP	2260	11116	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The t -LRB- 6 ; 8 -RRB- -LRB- q27 ; p11 -RRB- translocation in a stem cell myeloproliferative_disorder fuses a novel gene , FOP , to fibroblast_growth_factor_receptor_1 .
18566132	0	fibroblast_growth_factor_receptor_1	45,80	Fibroblast_growth_factor_8	0,26	fibroblast growth factor receptor 1	Fibroblast growth factor 8	14182(Tax:10090)	14179(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Fibroblast_growth_factor_8 signaling through fibroblast_growth_factor_receptor_1 is required for the emergence of gonadotropin-releasing hormone neurons .
9499416	0	fibroblast_growth_factor_receptor_1	104,139	RAMP	161,165	fibroblast growth factor receptor 1	RAMP	2260	25891	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	The t -LRB- 8 ; 13 -RRB- -LRB- p11 ; q11-12 -RRB- rearrangement associated with an atypical myeloproliferative_disorder fuses the fibroblast_growth_factor_receptor_1 gene to a novel gene RAMP .
19696444	0	fibroblast_growth_factor_receptor_1	20,55	anosmin-1	99,108	fibroblast growth factor receptor 1	anosmin-1	2260	3730	Gene	Gene	regulation|amod|START_ENTITY mechanisms|nmod|regulation mechanisms|nmod|END_ENTITY	Novel mechanisms of fibroblast_growth_factor_receptor_1 regulation by extracellular matrix protein anosmin-1 .
25784116	0	fibroblast_growth_factor_receptor_1	69,104	pyruvate_kinase_M2	19,37	fibroblast growth factor receptor 1	pyruvate kinase M2	2260	5315	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of pyruvate_kinase_M2 and lactate_dehydrogenase_a by fibroblast_growth_factor_receptor_1 in benign and malignant thyroid tissue .
25880801	0	fibroblast_growth_factor_receptor_1	69,104	pyruvate_kinase_M2	19,37	fibroblast growth factor receptor 1	pyruvate kinase M2	2260	5315	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of pyruvate_kinase_M2 and lactate_dehydrogenase_A by fibroblast_growth_factor_receptor_1 in benign and malignant thyroid tissue .
25880801	0	fibroblast_growth_factor_receptor_1	69,104	pyruvate_kinase_M2	19,37	fibroblast growth factor receptor 1	pyruvate kinase M2	2260	5315	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of pyruvate_kinase_M2 and lactate_dehydrogenase_A by fibroblast_growth_factor_receptor_1 in benign and malignant thyroid tissue .
16856175	0	fibroblast_growth_factor_receptor_2	20,55	FGFR-2	57,63	fibroblast growth factor receptor 2	FGFR-2	25022(Tax:10116)	25022(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Cytoarchitecture of fibroblast_growth_factor_receptor_2 -LRB- FGFR-2 -RRB- immunoreactivity in astrocytes of neurogenic and non-neurogenic regions of the young adult and aged rat brain .
10196476	0	fibroblast_growth_factor_receptor_2	34,69	FGFR2	71,76	fibroblast growth factor receptor 2	FGFR2	2263	2263	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the human fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- gene and comparative analysis of the human FGFR gene family .
11711827	0	fibroblast_growth_factor_receptor_2	21,56	FGFR2	59,64	fibroblast growth factor receptor 2	FGFR2	2263	2263	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Sequence analysis of fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- in Japanese patients with craniosynostosis .
15206560	0	fibroblast_growth_factor_receptor_2	136,171	FGFR2	178,183	fibroblast growth factor receptor 2	FGFR2	2263	2263	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinically mild , atypical , and aged craniofacial_syndrome is diagnosed as Crouzon_syndrome by identification of a point mutation in the fibroblast_growth_factor_receptor_2 gene -LRB- FGFR2 -RRB- .
26600631	0	fibroblast_growth_factor_receptor_2	47,82	FGFR2	84,89	fibroblast growth factor receptor 2	FGFR2	2263	2263	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of exons 8 , 9 and 10 of the fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- gene in two families with index cases of Apert Syndrome .
9150725	0	fibroblast_growth_factor_receptor_2	39,74	FGFR2	76,81	fibroblast growth factor receptor 2	FGFR2	2263	2263	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Trp290Cys mutation in exon IIIa of the fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- gene is associated with Pfeiffer_syndrome .
16709412	0	fibroblast_growth_factor_receptor_2	43,78	neural_cell_adhesion_molecule	4,33	fibroblast growth factor receptor 2	neural cell adhesion molecule	2263	4684	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The neural_cell_adhesion_molecule binds to fibroblast_growth_factor_receptor_2 .
14562121	0	fibroblast_growth_factor_receptor_3	24,59	BCR-ABL	69,76	fibroblast growth factor receptor 3	BCR-ABL	2261	25	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Increased expression of fibroblast_growth_factor_receptor_3 in CD34 + BCR-ABL + cells from patients with chronic_myeloid_leukemia .
14562121	0	fibroblast_growth_factor_receptor_3	24,59	CD34	63,67	fibroblast growth factor receptor 3	CD34	2261	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Increased expression of fibroblast_growth_factor_receptor_3 in CD34 + BCR-ABL + cells from patients with chronic_myeloid_leukemia .
16801131	0	fibroblast_growth_factor_receptor_3	34,69	FGF1	19,23	fibroblast growth factor receptor 3	FGF1	2261	2246	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Reduced binding of FGF1 to mutant fibroblast_growth_factor_receptor_3 .
1662791	0	fibroblast_growth_factor_receptor_3	52,87	FGFR-3	89,95	fibroblast growth factor receptor 3	FGFR-3	2261	2261	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structural and biosynthetic characterization of the fibroblast_growth_factor_receptor_3 -LRB- FGFR-3 -RRB- protein .
10914960	0	fibroblast_growth_factor_receptor_3	31,66	FGFR3	73,78	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A unique point mutation in the fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- causes non-syndromic_craniosynostosis .
11245416	0	fibroblast_growth_factor_receptor_3	4,39	FGFR3	41,46	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	The fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- mutation is a strong indicator of superficial bladder_cancer with low recurrence rate .
12354143	0	fibroblast_growth_factor_receptor_3	11,46	FGFR3	48,53	fibroblast growth factor receptor 3	FGFR3	281769(Tax:9913)	281769(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The bovine fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- gene is not the locus responsible for bovine chondrodysplastic_dwarfism in Japanese brown cattle .
19551630	0	fibroblast_growth_factor_receptor_3	32,67	FGFR3	69,74	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The G1138A mutation rate in the fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- gene is increased in cells carrying the t -LRB- 4 ; 14 -RRB- translocation .
20439987	0	fibroblast_growth_factor_receptor_3	30,65	FGFR3	67,72	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	NF449 is a novel inhibitor of fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- signaling active in chondrocytes and multiple myeloma cells .
21264819	0	fibroblast_growth_factor_receptor_3	13,48	FGFR3	55,60	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Incidence of fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- A248C , S249C , G372C , and T375C mutations in bladder_cancer .
25505835	0	fibroblast_growth_factor_receptor_3	63,98	FGFR3	100,105	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequency of the allelic variant c. 1150T _ > _ C in exon 10 of the fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- gene is not increased in patients with pathogenic mutations and related chondrodysplasia phenotypes .
8428519	0	fibroblast_growth_factor_receptor_3	4,39	FGFR3	46,51	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- is assigned to human chromosome 4 .
9042914	0	fibroblast_growth_factor_receptor_3	31,66	FGFR3	73,78	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A unique point mutation in the fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- defines a new craniosynostosis_syndrome .
9254852	0	fibroblast_growth_factor_receptor_3	6,41	FGFR3	48,53	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human fibroblast_growth_factor_receptor_3 gene -LRB- FGFR3 -RRB- : genomic sequence and primer set information for gene analysis .
9279764	0	fibroblast_growth_factor_receptor_3	29,64	FGFR3	66,71	fibroblast growth factor receptor 3	FGFR3	2261	2261	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Phenotypic expression of the fibroblast_growth_factor_receptor_3 -LRB- FGFR3 -RRB- mutation P250R in a large craniosynostosis family .
8723101	0	fibroblast_growth_factor_receptor_3	24,59	FGFR_3	61,67	fibroblast growth factor receptor 3	FGFR 3	2261	2261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common mutations in the fibroblast_growth_factor_receptor_3 -LRB- FGFR_3 -RRB- gene account for achondroplasia , hypochondroplasia , and thanatophoric_dwarfism .
8586414	0	fibroblast_growth_factor_receptor_3	34,69	Fgfr3	71,76	fibroblast growth factor receptor 3	Fgfr3	14184(Tax:10090)	14184(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the mouse fibroblast_growth_factor_receptor_3 -LRB- Fgfr3 -RRB- gene .
20657013	0	fibroblast_growth_factor_receptor_4	46,81	betaKlotho	20,30	fibroblast growth factor receptor 4	betaKlotho	2264	152831	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Metabolic regulator betaKlotho interacts with fibroblast_growth_factor_receptor_4 -LRB- FGFR4 -RRB- to induce apoptosis and inhibit tumor cell proliferation .
15750181	0	fibroblast_growth_factor_receptor_4	118,153	c-Jun_N-terminal_kinase	64,87	fibroblast growth factor receptor 4	c-Jun N-terminal kinase	14186(Tax:10090)	26419(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Independent repression of bile_acid synthesis and activation of c-Jun_N-terminal_kinase -LRB- JNK -RRB- by activated hepatocyte fibroblast_growth_factor_receptor_4 -LRB- FGFR4 -RRB- and bile_acids .
10196222	0	fibroblast_growth_factor_receptor_substrate_2	61,106	Brain-derived_neurotrophic_factor	0,33	fibroblast growth factor receptor substrate 2	Brain-derived neurotrophic factor	10818	627	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor induces phosphorylation of fibroblast_growth_factor_receptor_substrate_2 .
9286594	0	fibroblast_growth_factor_receptors	14,48	FGFR1	50,55	fibroblast growth factor receptors	FGFR1	2260	2260	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of fibroblast_growth_factor_receptors -LRB- FGFR1 , FGFR2 , FGFR3 -RRB- in the developing head and face .
11704499	0	fibroblast_growth_factor_type_I_receptor	41,81	FGFR1	83,88	fibroblast growth factor type I receptor	FGFR1	79114(Tax:10116)	79114(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Spatial and temporal gene expression for fibroblast_growth_factor_type_I_receptor -LRB- FGFR1 -RRB- during fracture healing in the rat .
10446183	0	fibroglycan	82,93	syndecan-2	70,80	fibroglycan	syndecan-2	6383	6383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 -LRB- fibroglycan -RRB- on human activated macrophages can regulate fibroblast growth factor action .
16046396	0	fibromodulin	43,55	C1q	122,125	fibromodulin	C1q	2331	712	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	The extracellular matrix and inflammation : fibromodulin activates the classical pathway of complement by directly binding C1q .
19966216	0	fibronectin	25,36	PDGF-A	0,6	fibronectin	PDGF-A	397744(Tax:8355)	397765(Tax:8355)	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	PDGF-A interactions with fibronectin reveal a critical role for heparan sulfate in directed cell migration during Xenopus gastrulation .
10409747	0	fibronectin	51,62	beta-catenin	29,41	fibronectin	beta-catenin	397744(Tax:8355)	399274(Tax:8355)	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	The Wnt/Wg signal transducer beta-catenin controls fibronectin expression .
23895273	0	fibronectin_1	13,26	SOX2	0,4	fibronectin 1	SOX2	2335	6657	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	SOX2 targets fibronectin_1 to promote cell migration and invasion in ovarian_cancer : new molecular leads for therapeutic intervention .
11836357	0	fibulin-1	4,13	FBLN1	20,25	fibulin-1	FBLN1	2192	2192	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The fibulin-1 gene -LRB- FBLN1 -RRB- is disrupted in a t -LRB- 12 ; 22 -RRB- associated with a complex type of synpolydactyly .
7806231	0	fibulin-1	4,13	FBLN1	20,25	fibulin-1	FBLN1	2192	2192	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The fibulin-1 gene -LRB- FBLN1 -RRB- is located on human chromosome 22 and on mouse chromosome 15 .
16338003	0	fibulin-1	38,47	Fbln1	49,54	fibulin-1	Fbln1	14114(Tax:10090)	14114(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY END_ENTITY|nsubj|analysis	Expression and functional analysis of fibulin-1 -LRB- Fbln1 -RRB- during normal and abnormal placental development of the mouse .
7642629	0	fibulin-1	19,28	fibrinogen	34,44	fibulin-1	fibrinogen	2192	2244	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of fibulin-1 with fibrinogen .
23036802	0	fibulin-1	95,104	heart_and_neural_crest_derivatives_expressed_transcript_2	18,75	fibulin-1	heart and neural crest derivatives expressed transcript 2	2192	9464	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	Progestin-induced heart_and_neural_crest_derivatives_expressed_transcript_2 is associated with fibulin-1 expression in human endometrial stromal cells .
19275936	0	fibulin-3	20,29	ECM1	0,4	fibulin-3	ECM1	2202	1893	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ECM1 interacts with fibulin-3 and the beta 3 chain of laminin 332 through its serum albumin subdomain-like 2 domain .
12189163	0	fibulin-5	40,49	FBLN5	51,56	fibulin-5	FBLN5	10516	10516	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Homozygosity for a missense mutation in fibulin-5 -LRB- FBLN5 -RRB- results in a severe form of cutis_laxa .
12618961	0	fibulin-5	82,91	FBLN5	93,98	fibulin-5	FBLN5	10516	10516	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic heterogeneity of cutis_laxa : a heterozygous tandem duplication within the fibulin-5 -LRB- FBLN5 -RRB- gene .
23619474	0	ficolin-2	50,59	L-ficolin	61,70	ficolin-2	L-ficolin	2220	2220	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	The relationship between FCN2 genotypes and serum ficolin-2 -LRB- L-ficolin -RRB- protein concentrations from a large cohort of neonates .
18032536	0	ficolin_1	21,30	FCN1	37,41	ficolin 1	FCN1	2219	2219	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the ficolin_1 gene -LRB- FCN1 -RRB- are associated with susceptibility to the development of rheumatoid_arthritis .
22229441	0	filaggrin	20,29	IL-17	0,5	filaggrin	IL-17	2312	3605	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion .
26867960	0	filaggrin	21,30	IL-33	0,5	filaggrin	IL-33	2312	90865	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	IL-33 down-regulates filaggrin expression by inducing STAT3 and ERK phosphorylation in human keratinocytes .
21564072	0	filaggrin	29,38	Interleukin-22	0,14	filaggrin	Interleukin-22	2312	50616	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes .
21346775	0	filaggrin	20,29	TNF-a	0,5	filaggrin	TNF-a	2312	7124	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	TNF-a downregulates filaggrin and loricrin through c-Jun N-terminal kinase : role for TNF-a antagonists to improve skin barrier .
24155988	0	filaggrin	63,72	part_1	43,49	filaggrin	part 1	2312	25859	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Atopic_dermatitis and the stratum corneum : part_1 : the role of filaggrin in the stratum corneum barrier and atopic skin .
11482904	0	filamin	19,26	ABP-280	28,35	filamin	ABP-280	2318	2318	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of filamin -LRB- ABP-280 -RRB- regulates the binding to the lipid membrane , integrin , and actin .
7534799	0	filamin	22,29	ABP-280	31,38	filamin	ABP-280	2318	2318	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Direct interaction of filamin -LRB- ABP-280 -RRB- with the beta_2-integrin subunit CD18 .
7534799	0	filamin	22,29	CD18	73,77	filamin	CD18	2318	3689	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of filamin -LRB- ABP-280 -RRB- with the beta_2-integrin subunit CD18 .
10051605	0	filamin	30,37	RalA	17,21	filamin	RalA	2318	5898	Gene	Gene	START_ENTITY|nsubj|targets targets|compound|END_ENTITY	The small GTPase RalA targets filamin to induce filopodia .
12903776	0	filamin	33,40	myosin	81,87	filamin	myosin	2318	79784	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The bi-directional regulation of filamin on the ATPase activity of smooth muscle myosin .
10984440	0	filamin	36,43	presenilin	49,59	filamin	presenilin	42066(Tax:7227)	40260(Tax:7227)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and genetic interaction of filamin with presenilin in Drosophila .
17060905	0	filamin-A	22,31	CD28	0,4	filamin-A	CD28	2316	940	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse .
23636454	0	filamin-A	21,30	RACK1	0,5	filamin-A	RACK1	2316	10399	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RACK1 interacts with filamin-A to regulate plasma membrane levels of the cystic_fibrosis_transmembrane_conductance_regulator .
22556421	0	filamin-binding_LIM_protein_1	17,46	migfilin	56,64	filamin-binding LIM protein 1	migfilin	74202(Tax:10090)	74202(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Critical role of filamin-binding_LIM_protein_1 -LRB- FBLP-1 -RRB- / migfilin in regulation of bone remodeling .
11389901	0	filamin_A	31,40	ABP-280	42,49	filamin A	ABP-280	2316	2316	Gene	Gene	molecules|compound|START_ENTITY molecules|compound|END_ENTITY	Mechanical unfolding of single filamin_A -LRB- ABP-280 -RRB- molecules detected by atomic force microscopy .
16291724	0	filamin_A	36,45	CEACAM1	0,7	filamin A	CEACAM1	2316	634	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CEACAM1 functionally interacts with filamin_A and exerts a dual role in the regulation of cell migration .
25445790	0	filamin_A	47,56	Cdk1	32,36	filamin A	Cdk1	2316	983	Gene	Gene	localization|compound|START_ENTITY regulates|dobj|localization regulates|nsubj|Phosphorylation Phosphorylation|nmod|filamin_A filamin_A|nmod|END_ENTITY	Phosphorylation of filamin_A by Cdk1 regulates filamin_A localization and daughter cell separation .
25614868	0	filamin_A	78,87	FLNA	89,93	filamin A	FLNA	2316	2316	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Terminal_osseous_dysplasia_with_pigmentary_defects -LRB- TODPD -RRB- due to a recurrent filamin_A -LRB- FLNA -RRB- mutation .
26804200	0	filamin_A	131,140	FLNA	142,146	filamin A	FLNA	2316	2316	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A distinct X-linked_syndrome involving joint_contractures , keloids , large optic cup-to-disc ratio , and renal_stones results from a filamin_A -LRB- FLNA -RRB- mutation .
21926999	0	filamin_A	77,86	FilGAP	46,52	filamin A	FilGAP	2316	83478	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin_A .
21709252	0	filamin_A	27,36	RefilinB	0,8	filamin A	RefilinB	2316	359845	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	RefilinB -LRB- FAM101B -RRB- targets filamin_A to organize perinuclear actin networks and regulates nuclear shape .
26707877	0	filamin_A	31,40	RhoGDI2	46,53	filamin A	RhoGDI2	2316	397	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	An adventitious interaction of filamin_A with RhoGDI2 -LRB- Tyr153Glu -RRB- .
21359179	0	filamin_A	59,68	androgen_receptor	41,58	filamin A	androgen receptor	2316	367	Gene	Gene	association|compound|START_ENTITY association|compound|END_ENTITY	Androgen-induced cell migration : role of androgen_receptor / filamin_A association .
15225631	0	filamin_A	15,24	integrin_beta_7	34,49	filamin A	integrin beta 7	2316	3695	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Interaction of filamin_A with the integrin_beta_7 cytoplasmic domain : role of alternative splicing and phosphorylation .
24963132	0	filamin_C	24,33	Aciculin	0,8	filamin C	Aciculin	2318	5239	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Aciculin interacts with filamin_C and Xin and is essential for myofibril assembly , remodeling and maintenance .
18556573	0	filamin_a	31,40	ECSM2	0,5	filamin a	ECSM2	2316	641700	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ECSM2 , an endothelial specific filamin_a binding protein that mediates chemotaxis .
18799729	0	filamins_A_and_B	13,29	ASB2	0,4	filamins A and B	ASB2	2316;2317	51676	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	ASB2 targets filamins_A_and_B to proteasomal degradation .
14756805	0	fimbrin	52,59	Iba1	38,42	fimbrin	Iba1	5357	199	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity .
10101157	0	fimbrin	23,30	Sac6p	32,37	fimbrin	Sac6p	851707(Tax:4932)	851707(Tax:4932)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Suppressor analysis of fimbrin -LRB- Sac6p -RRB- overexpression in yeast .
20519143	0	five-lipoxygenase-activating_protein	41,77	AM803	16,21	five-lipoxygenase-activating protein	AM803	29624(Tax:10116)	3171503(Tax:234826)	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Pharmacology of AM803 , a novel selective five-lipoxygenase-activating_protein -LRB- FLAP -RRB- inhibitor in rodent models of acute inflammation .
11430825	0	flap_endonuclease-1	20,39	p300	104,108	flap endonuclease-1	p300	2237	2033	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of human flap_endonuclease-1 activity by acetylation through the transcriptional coactivator p300 .
12065902	0	flap_endonuclease_1	21,40	flap_endonuclease_1	109,128	flap endonuclease 1	flap endonuclease 1	2237	2237	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|dep|role role|nmod|END_ENTITY	Stimulation of human flap_endonuclease_1 by human_immunodeficiency_virus_type_1 integrase : possible role for flap_endonuclease_1 in 5 ' - end processing of human_immunodeficiency_virus_type_1 integration intermediates .
10744741	0	flap_endonuclease_1	64,83	proliferating_cell_nuclear_antigen	18,52	flap endonuclease 1	proliferating cell nuclear antigen	2237	5111	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Mechanism whereby proliferating_cell_nuclear_antigen stimulates flap_endonuclease_1 .
27020684	0	flap_structure-specific_endonuclease_1	23,61	FEN1	63,67	flap structure-specific endonuclease 1	FEN1	2237	2237	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Investigation of human flap_structure-specific_endonuclease_1 -LRB- FEN1 -RRB- activity on primer-template models and exploration of a substrate-based FEN1 inhibitor .
25460299	0	flavin-containing_mono-oxygenase	14,46	Fmo3	48,52	flavin-containing mono-oxygenase	Fmo3	14262(Tax:10090)	14262(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of flavin-containing_mono-oxygenase -LRB- Fmo3 -RRB- gene expression by steroids in mice and humans .
9398858	0	flavin-containing_mono-oxygenase_3	21,55	FMO3	62,66	flavin-containing mono-oxygenase 3	FMO3	2328	2328	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|appos|END_ENTITY	Missense mutation in flavin-containing_mono-oxygenase_3 gene , FMO3 , underlies fish-odour_syndrome .
9509414	0	flavin-containing_monooxygenase	13,44	FMO1	46,50	flavin-containing monooxygenase	FMO1	25256(Tax:10116)	25256(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of flavin-containing_monooxygenase -LRB- FMO1 -RRB- by a polycyclic_aromatic_hydrocarbon , 3-methylcholanthrene , in rat liver .
9804831	0	flavin-containing_monooxygenase_2	4,37	FMO2	44,48	flavin-containing monooxygenase 2	FMO2	2327	2327	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The flavin-containing_monooxygenase_2 gene -LRB- FMO2 -RRB- of humans , but not of other primates , encodes a truncated , nonfunctional protein .
17885620	0	flavin-containing_monooxygenase_3	51,84	FMO3	91,95	flavin-containing monooxygenase 3	FMO3	2328	2328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular evolution and balancing selection in the flavin-containing_monooxygenase_3 gene -LRB- FMO3 -RRB- .
18305374	0	flavin-containing_monooxygenase_3	71,104	FMO3	106,110	flavin-containing monooxygenase 3	FMO3	2328	2328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Complex mechanism underlying transcriptional control of the haplotyped flavin-containing_monooxygenase_3 -LRB- FMO3 -RRB- gene in Japanese : different regulation between mutations in 5 ' - upstream distal region and common element in proximal region .
19321370	0	flavin-containing_monooxygenase_3	28,61	FMO3	63,67	flavin-containing monooxygenase 3	FMO3	2328	2328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel variants of the human flavin-containing_monooxygenase_3 -LRB- FMO3 -RRB- gene associated with trimethylaminuria .
19577495	0	flavin-containing_monooxygenase_3	24,57	FMO3	64,68	flavin-containing monooxygenase 3	FMO3	2328	2328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the flavin-containing_monooxygenase_3 gene -LRB- FMO3 -RRB- of a Norwegian family causes trimethylaminuria .
9417913	0	flavin-containing_monooxygenase_3	37,70	FMO3	77,81	flavin-containing monooxygenase 3	FMO3	2328	2328	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural organization of the human flavin-containing_monooxygenase_3 gene -LRB- FMO3 -RRB- , the favored candidate for fish-odor_syndrome , determined directly from genomic DNA .
1321062	0	flg	59,62	FGFR-1	52,58	flg	FGFR-1	14246(Tax:10090)	14182(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of the fibroblast growth factor receptor FGFR-1 / flg during gastrulation and segmentation in the mouse embryo .
11991951	0	fli-1	16,21	Ets-1	0,5	fli-1	Ets-1	14247(Tax:10090)	23871(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ets-1 regulates fli-1 expression in endothelial cells .
10455194	0	flk-1	112,117	KDR	118,121	flk-1	KDR	3791	3791	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
11098056	0	flk-1	61,66	KDR	67,70	flk-1	KDR	3791	3791	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Transforming_growth_factor-beta_1-mediated inhibition of the flk-1 / KDR gene is mediated by a 5 ' - untranslated region palindromic GATA site .
10604730	0	flk-1	78,83	VEGF	53,57	flk-1	VEGF	25589(Tax:10116)	83785(Tax:10116)	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Co-expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- flk-1 and flt-1 -RRB- in hormone-induced mammary cancer in the Noble rat .
10455194	0	flk-1	112,117	Vascular_endothelial_growth_factor	0,34	flk-1	Vascular endothelial growth factor	3791	7422	Gene	Gene	activation|amod|START_ENTITY signals|nmod|activation signals|nsubj|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
11122336	0	flk-1	106,111	Vascular_endothelial_growth_factor	0,34	flk-1	Vascular endothelial growth factor	16542(Tax:10090)	22339(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY stimulates|nmod|receptor factor|acl:relcl|stimulates factor|nsubj|END_ENTITY	Vascular_endothelial_growth_factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor .
10455194	0	flk-1	112,117	c-Src	136,141	flk-1	c-Src	3791	6714	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Vascular_endothelial_growth_factor signals endothelial cell production of nitric_oxide and prostacyclin through flk-1 / KDR activation of c-Src .
10211995	0	flk-1	197,202	vascular_endothelial_growth_factor	153,187	flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|dep|receptor receptor|compound|END_ENTITY	Hepatocyte growth factor increases expression of vascular_endothelial_growth_factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular_endothelial_growth_factor receptor flk-1 in human endothelial cells .
15235888	0	flk-1	62,67	vascular_endothelial_growth_factor	14,48	flk-1	vascular endothelial growth factor	3791	7422	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor and receptor flk-1 in colon_cancer_liver_metastases .
9216738	0	flk-2	8,13	flt3	14,18	flk-2	flt3	14255(Tax:10090)	14255(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY Loss|dep|expression expression|amod|END_ENTITY	Loss of flk-2 / flt3 expression during commitment of multipotent mouse hematopoietic progenitor cells to the mast cell lineage .
17306248	0	flk1	27,31	FoxH1	0,5	flk1	FoxH1	554230(Tax:7955)	57930(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish .
17702981	0	flk1	81,85	vascular_endothelial_growth_factor_receptor-2	21,66	flk1	vascular endothelial growth factor receptor-2	16542(Tax:10090)	16542(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Lentiviral rescue of vascular_endothelial_growth_factor_receptor-2 expression in flk1 - / - embryonic stem cells shows early priming of endothelial precursors .
7681159	0	flk2	53,57	flt3	47,51	flk2	flt3	2322	2322	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the protein encoded by the flt3 -LRB- flk2 -RRB- receptor-like_tyrosine_kinase gene .
7681159	0	flk2	53,57	receptor-like_tyrosine_kinase	59,88	flk2	receptor-like tyrosine kinase	2322	6259	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of the protein encoded by the flt3 -LRB- flk2 -RRB- receptor-like_tyrosine_kinase gene .
20430883	0	flotillin-1	56,67	aurora_B	14,22	flotillin-1	aurora B	10211	9212	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of aurora_B kinase by the lipid raft protein flotillin-1 .
15120622	0	flotillin-1	33,44	neuroglobin	6,17	flotillin-1	neuroglobin	10211	58157	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human neuroglobin interacts with flotillin-1 , a lipid raft microdomain-associated protein .
18219274	0	flotillin-2	9,20	Reggie-1	0,8	flotillin-2	Reggie-1	32425(Tax:7227)	32425(Tax:7227)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Reggie-1 / flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila .
8126087	0	flt	50,53	VEGF	35,39	flt	VEGF	2321	7422	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|receptors receptors|compound|END_ENTITY	Differential expression of the two VEGF receptors flt and KDR in placenta and vascular endothelial cells .
8671397	0	flt	53,56	VEGF	16,20	flt	VEGF	2321	7422	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy .
8568762	0	flt	69,72	vascular_endothelial_growth_factor	16,50	flt	vascular endothelial growth factor	2321	7422	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of vascular_endothelial_growth_factor and its receptor , flt , in human placenta and decidua by immunohistochemistry .
9463589	0	flt	83,86	vascular_endothelial_growth_factor	31,65	flt	vascular endothelial growth factor	2321	7422	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and localization of vascular_endothelial_growth_factor and its receptor flt in pulmonary_sarcoidosis .
10398412	0	flt-1	89,94	VEGF	50,54	flt-1	VEGF	503620(Tax:9913)	281572(Tax:9913)	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its corresponding receptors -LRB- flt-1 and flk-1 -RRB- in the bovine oviduct .
16432214	0	flt-1	13,18	VEGF	43,47	flt-1	VEGF	2321	7422	Gene	Gene	promoter|amod|START_ENTITY SNP|nmod|promoter integrates|nsubj|SNP integrates|dobj|system system|compound|END_ENTITY	A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network .
18478945	0	flt-1	117,122	VEGF	111,115	flt-1	VEGF	2321	7422	Gene	Gene	antisense|xcomp|START_ENTITY antisense|nmod|mRNA mRNA|nmod|END_ENTITY	-LSB- Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotide on mRNA and expression of VEGF , flt-1 , and kinase_insert_domain_containing_receptor and VEGF excretion in human gallbladder_carcinoma cells -RSB- .
18478945	0	flt-1	117,122	VEGF	48,52	flt-1	VEGF	2321	7422	Gene	Gene	antisense|xcomp|START_ENTITY antisense|nsubj|Effects Effects|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotide on mRNA and expression of VEGF , flt-1 , and kinase_insert_domain_containing_receptor and VEGF excretion in human gallbladder_carcinoma cells -RSB- .
18482723	0	flt-1	39,44	VEGF	24,28	flt-1	VEGF	2321	7422	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|dobj|receptors	Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain_injury .
20030917	0	flt-1	57,62	VEGF	43,47	flt-1	VEGF	2321	7422	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Inhibition effect of short hairpin RNA on VEGF receptor flt-1 gene expression in leukemia cell line K562 -RSB- .
7535833	0	flt-1	96,101	VEGF	72,76	flt-1	VEGF	2321	7422	Gene	Gene	vascular_endothelial_growth_factor|dep|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- Expression and subtype analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptor -LRB- flt-1 -RRB- in human ovarian_tumors -RSB- .
8605350	0	flt-1	120,125	VEGF	80,84	flt-1	VEGF	2321	7422	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Migration Migration|appos|END_ENTITY	Migration of human monocytes in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- is mediated via the VEGF receptor flt-1 .
9777366	0	flt-1	100,105	VEGF	84,88	flt-1	VEGF	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptors|xcomp|START_ENTITY receptors|nsubj|Evidence Evidence|appos|END_ENTITY	Evidence for upregulation and redistribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors flt-1 and flk-1 in the oxygen-injured rat retina .
9776730	0	flt-1	132,137	Vascular_endothelial_growth_factor	0,34	flt-1	Vascular endothelial growth factor	2321	7422	Gene	Gene	role|nmod|START_ENTITY expression|dep|role upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells : role of flt-1 .
12142732	0	flt-1	79,84	vascular_endothelial_growth_factor	85,119	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Gene therapy for pancreatic_cancer using an adenovirus vector encoding soluble flt-1 vascular_endothelial_growth_factor receptor .
15515760	0	flt-1	69,74	vascular_endothelial_growth_factor	15,49	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of vascular_endothelial_growth_factor and its receptors -LRB- flt-1 -RRB- in morbid human corneas and investigation of its clinic importance -RSB- .
17099154	0	flt-1	103,108	vascular_endothelial_growth_factor	14,48	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor , basic_fibroblast_growth_factor , and their receptors -LRB- flt-1 , flk-1 , and flg-1 -RRB- in canine vascular_tumors .
18478945	0	flt-1	117,122	vascular_endothelial_growth_factor	12,46	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	antisense|xcomp|START_ENTITY antisense|nsubj|Effects Effects|nmod|END_ENTITY	-LSB- Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotide on mRNA and expression of VEGF , flt-1 , and kinase_insert_domain_containing_receptor and VEGF excretion in human gallbladder_carcinoma cells -RSB- .
7499271	0	flt-1	66,71	vascular_endothelial_growth_factor	21,55	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	receptor|dep|START_ENTITY receptor|compound|END_ENTITY	A novel promoter for vascular_endothelial_growth_factor receptor -LRB- flt-1 -RRB- that confers endothelial-specific gene expression .
8605350	0	flt-1	120,125	vascular_endothelial_growth_factor	44,78	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Migration Migration|nmod|monocytes monocytes|nmod|response response|nmod|END_ENTITY	Migration of human monocytes in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- is mediated via the VEGF receptor flt-1 .
8940064	0	flt-1	91,96	vascular_endothelial_growth_factor	114,148	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	tyrosine|amod|START_ENTITY gene|amod|tyrosine gene|dep|receptor receptor|compound|END_ENTITY	A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase -LRB- vascular_endothelial_growth_factor receptor 1 -RRB- gene .
9042161	0	flt-1	58,63	vascular_endothelial_growth_factor	106,140	flt-1	vascular endothelial growth factor	2321	7422	Gene	Gene	receptors|dep|START_ENTITY express|dobj|receptors express|nmod|END_ENTITY	Uterine smooth muscle cells express functional receptors -LRB- flt-1 and KDR -RRB- for vascular_permeability_factor / vascular_endothelial_growth_factor .
9777366	0	flt-1	100,105	vascular_endothelial_growth_factor	48,82	flt-1	vascular endothelial growth factor	54251(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptors|xcomp|START_ENTITY receptors|nsubj|Evidence Evidence|nmod|END_ENTITY	Evidence for upregulation and redistribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors flt-1 and flk-1 in the oxygen-injured rat retina .
9216738	0	flt3	14,18	flk-2	8,13	flt3	flk-2	14255(Tax:10090)	14255(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Loss|dep|expression Loss|nmod|END_ENTITY	Loss of flk-2 / flt3 expression during commitment of multipotent mouse hematopoietic progenitor cells to the mast cell lineage .
7681159	0	flt3	47,51	flk2	53,57	flt3	flk2	2322	2322	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the protein encoded by the flt3 -LRB- flk2 -RRB- receptor-like_tyrosine_kinase gene .
7681159	0	flt3	47,51	receptor-like_tyrosine_kinase	59,88	flt3	receptor-like tyrosine kinase	2322	6259	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Characterization of the protein encoded by the flt3 -LRB- flk2 -RRB- receptor-like_tyrosine_kinase gene .
10554817	0	flt3-ligand	103,114	thrombopoietin	87,101	flt3-ligand	thrombopoietin	2323	7066	Gene	Gene	granulocyte-colony_stimulating_factor|amod|START_ENTITY granulocyte-colony_stimulating_factor|compound|END_ENTITY	Myeloid differentiation of human cord blood CD34 + cells during ex vivo expansion using thrombopoietin , flt3-ligand and/or granulocyte-colony_stimulating_factor .
21262836	0	flt3L	67,72	FMS-like_tyrosine_kinase_3_receptor	23,58	flt3L	FMS-like tyrosine kinase 3 receptor	14256(Tax:10090)	14256(Tax:10090)	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	Interleukin-2 inhibits FMS-like_tyrosine_kinase_3_receptor ligand -LRB- flt3L -RRB- - dependent development and function of conventional and plasmacytoid dendritic cells .
21262836	0	flt3L	67,72	Interleukin-2	0,13	flt3L	Interleukin-2	14256(Tax:10090)	16183(Tax:10090)	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	Interleukin-2 inhibits FMS-like_tyrosine_kinase_3_receptor ligand -LRB- flt3L -RRB- - dependent development and function of conventional and plasmacytoid dendritic cells .
2421214	0	fluoride-resistant_acid_phosphatase	20,55	FRAP	57,61	fluoride-resistant acid phosphatase	FRAP	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	The localization of fluoride-resistant_acid_phosphatase -LRB- FRAP -RRB- in the pelvic nerves and sacral spinal cord of rats .
12536050	0	fluoride_resistant_acid_phosphatase	33,68	FRAP	70,74	fluoride resistant acid phosphatase	FRAP	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inflammation induced increase of fluoride_resistant_acid_phosphatase -LRB- FRAP -RRB- activity in the spinal dorsal horn in rats .
9393770	0	fms-like_tyrosine_kinase_1	61,87	FLT-1	89,94	fms-like tyrosine kinase 1	FLT-1	2321	2321	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor up-regulates its receptor fms-like_tyrosine_kinase_1 -LRB- FLT-1 -RRB- and a soluble variant of FLT-1 in human vascular endothelial cells .
19318351	0	focal_adhesion_kinase	46,67	AGAP2	30,35	focal adhesion kinase	AGAP2	5747	116986	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Arf GTPase-activating protein AGAP2 regulates focal_adhesion_kinase activity and focal adhesion remodeling .
12242282	0	focal_adhesion_kinase	71,92	AKT	46,49	focal adhesion kinase	AKT	14083(Tax:10090)	11651(Tax:10090)	Gene	Gene	utilizing|dobj|START_ENTITY activates|advcl|utilizing activates|dobj|pathway pathway|compound|END_ENTITY	v-Crk activates the phosphoinositide_3-kinase / AKT pathway by utilizing focal_adhesion_kinase and H-Ras .
22948179	0	focal_adhesion_kinase	77,98	AKT	99,102	focal adhesion kinase	AKT	5747	207	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Sonic hedgehog signaling pathway induces cell migration and invasion through focal_adhesion_kinase / AKT signaling-mediated activation of matrix_metalloproteinase _ -LRB- MMP -RRB- -2 and MMP-9 in liver_cancer .
18948272	0	focal_adhesion_kinase	110,131	Akt	138,141	focal adhesion kinase	Akt	5747	207	Gene	Gene	proliferation|nmod|START_ENTITY proliferation|dep|END_ENTITY	MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 -LRB- MLC2 -RRB- / focal_adhesion_kinase -LRB- FAK -RRB- / Akt signaling pathway .
21209368	0	focal_adhesion_kinase	23,44	Akt	0,3	focal adhesion kinase	Akt	5747	207	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Akt directly regulates focal_adhesion_kinase through association and serine phosphorylation : implication for pressure-induced colon_cancer metastasis .
26579576	0	focal_adhesion_kinase	11,32	Akt1	0,4	focal adhesion kinase	Akt1	5747	207	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Akt1 binds focal_adhesion_kinase via the Akt1 kinase domain independently of the pleckstrin homology domain .
26579576	0	focal_adhesion_kinase	11,32	Akt1	41,45	focal adhesion kinase	Akt1	5747	207	Gene	Gene	START_ENTITY|nmod|domain domain|amod|END_ENTITY	Akt1 binds focal_adhesion_kinase via the Akt1 kinase domain independently of the pleckstrin homology domain .
12031795	0	focal_adhesion_kinase	29,50	Angiotensin_II	0,14	focal adhesion kinase	Angiotensin II	5747	183	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Angiotensin_II activation of focal_adhesion_kinase and pp60c-Src in relation to mitogen-activated protein kinases in hepatocytes .
15652490	0	focal_adhesion_kinase	23,44	Angiotensin_II	0,14	focal adhesion kinase	Angiotensin II	5747	183	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Angiotensin_II induces focal_adhesion_kinase / paxillin phosphorylation and cell migration in human umbilical vein endothelial cells .
10655504	0	focal_adhesion_kinase	63,84	CD4	102,105	focal adhesion kinase	CD4	5747	920	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	HIV-1 envelope induces activation of caspase-3 and cleavage of focal_adhesion_kinase in primary human CD4 -LRB- + -RRB- T cells .
12297287	0	focal_adhesion_kinase	23,44	CD44	0,4	focal adhesion kinase	CD44	14083(Tax:10090)	12505(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	CD44 signaling through focal_adhesion_kinase and its anti-apoptotic effect .
23463649	0	focal_adhesion_kinase	16,37	CaMK-II	79,86	focal adhesion kinase	CaMK-II	14083(Tax:10090)	12325(Tax:10090)	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Cadmium affects focal_adhesion_kinase -LRB- FAK -RRB- in mesangial cells : involvement of CaMK-II and the actin cytoskeleton .
15598735	0	focal_adhesion_kinase	16,37	CrkII	0,5	focal adhesion kinase	CrkII	5747	1398	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	CrkII regulates focal_adhesion_kinase activation by making a complex with Crk-associated_substrate , p130Cas .
11468295	0	focal_adhesion_kinase	21,42	Ezrin	0,5	focal adhesion kinase	Ezrin	100170770(Tax:9823)	100153898(Tax:9823)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ezrin interacts with focal_adhesion_kinase and induces its activation independently of cell-matrix adhesion .
11606050	0	focal_adhesion_kinase	32,53	FAK	55,58	focal adhesion kinase	FAK	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Uniaxial cyclic stretch induces focal_adhesion_kinase -LRB- FAK -RRB- tyrosine phosphorylation followed by mitogen-activated protein kinase -LRB- MAPK -RRB- activation .
12215217	0	focal_adhesion_kinase	24,45	FAK	47,50	focal adhesion kinase	FAK	5747	5747	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Antiapoptotic action of focal_adhesion_kinase -LRB- FAK -RRB- against ionizing radiation .
15174091	0	focal_adhesion_kinase	20,41	FAK	43,46	focal adhesion kinase	FAK	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	PDGF and FGF induce focal_adhesion_kinase -LRB- FAK -RRB- phosphorylation at Ser-910 : dissociation from Tyr-397 phosphorylation and requirement for ERK activation .
15564794	0	focal_adhesion_kinase	16,37	FAK	39,42	focal adhesion kinase	FAK	5747	5747	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of focal_adhesion_kinase -LRB- FAK -RRB- expression in ductal_carcinoma_in_situ -LRB- DCIS -RRB- is an early event in breast tumorigenesis .
16179862	0	focal_adhesion_kinase	10,31	FAK	58,61	focal adhesion kinase	FAK	5747	5747	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	Effect of focal_adhesion_kinase -LRB- FAK -RRB- downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines .
23275034	0	focal_adhesion_kinase	14,35	FAK	37,40	focal adhesion kinase	FAK	5747	5747	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Inhibition of focal_adhesion_kinase -LRB- FAK -RRB- activity prevents anchorage-independent ovarian_carcinoma cell growth and tumor progression .
7525620	0	focal_adhesion_kinase	23,44	FAK	46,49	focal adhesion kinase	FAK	399286(Tax:8355)	399286(Tax:8355)	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Concentration of pp125 focal_adhesion_kinase -LRB- FAK -RRB- at the myotendinous junction .
12221124	0	focal_adhesion_kinase	14,35	FIP200	65,71	focal adhesion kinase	FIP200	5747	9821	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of focal_adhesion_kinase by a novel protein inhibitor FIP200 .
23904105	0	focal_adhesion_kinase	24,45	FRNK	65,69	focal adhesion kinase	FRNK	5747	5747	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Quantitative changes in focal_adhesion_kinase and its inhibitor , FRNK , drive load-dependent expression of costamere components .
7766995	0	focal_adhesion_kinase	15,36	Fadk	38,42	focal adhesion kinase	Fadk	14083(Tax:10090)	14083(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the focal_adhesion_kinase -LRB- Fadk -RRB- gene to mouse chromosome 15 and human chromosome 8 .
18435487	0	focal_adhesion_kinase	43,64	Fas_ligand	90,100	focal adhesion kinase	Fas ligand	5747	356	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Geraniin-mediated apoptosis by cleavage of focal_adhesion_kinase through up-regulation of Fas_ligand expression in human melanoma cells .
8817572	0	focal_adhesion_kinase	24,45	Fyn	46,49	focal adhesion kinase	Fyn	25614(Tax:10116)	25150(Tax:10116)	Gene	Gene	association|amod|START_ENTITY association|compound|END_ENTITY	A_beta peptide enhances focal_adhesion_kinase / Fyn association in a rat CNS nerve cell line .
16631627	0	focal_adhesion_kinase	56,77	GADD153	32,39	focal adhesion kinase	GADD153	5747	1649	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Doxazosin induces activation of GADD153 and cleavage of focal_adhesion_kinase in cardiomyocytes en route to apoptosis .
10446223	0	focal_adhesion_kinase	15,36	Grb7	42,46	focal adhesion kinase	Grb7	5747	2886	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of focal_adhesion_kinase with Grb7 and its role in cell migration .
10893408	0	focal_adhesion_kinase	68,89	Grb7	8,12	focal adhesion kinase	Grb7	14083(Tax:10090)	14786(Tax:10090)	Gene	Gene	targeting|nmod|START_ENTITY Role|acl|targeting Role|nmod|END_ENTITY	Role of Grb7 targeting to focal contacts and its phosphorylation by focal_adhesion_kinase in regulation of cell migration .
9553131	0	focal_adhesion_kinase	79,100	Growth_hormone	0,14	focal adhesion kinase	Growth hormone	14083(Tax:10090)	14599(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
9553131	0	focal_adhesion_kinase	79,100	JAK2	112,116	focal adhesion kinase	JAK2	14083(Tax:10090)	16452(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nmod|END_ENTITY	Growth_hormone stimulates the tyrosine phosphorylation and association of p125 focal_adhesion_kinase -LRB- FAK -RRB- with JAK2 .
18353772	0	focal_adhesion_kinase	36,57	KLF8	14,18	focal adhesion kinase	KLF8	5747	11279	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Activation Activation|nmod|END_ENTITY	Activation of KLF8 transcription by focal_adhesion_kinase in human ovarian epithelial and cancer cells .
23637231	0	focal_adhesion_kinase	15,36	LKB1	0,4	focal adhesion kinase	LKB1	14083(Tax:10090)	20869(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	LKB1 represses focal_adhesion_kinase -LRB- FAK -RRB- signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence .
12458213	0	focal_adhesion_kinase	28,49	MEK_kinase_1	0,12	focal adhesion kinase	MEK kinase 1	14083(Tax:10090)	26401(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MEK_kinase_1 interacts with focal_adhesion_kinase and regulates insulin_receptor_substrate-1 expression .
17327229	0	focal_adhesion_kinase	16,37	N-MYC	0,5	focal adhesion kinase	N-MYC	5747	4613	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	N-MYC regulates focal_adhesion_kinase expression in human neuroblastoma .
20353839	0	focal_adhesion_kinase	75,96	NF-kappaB	14,23	focal adhesion kinase	NF-kappaB	5747	4790	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Activation Activation|nmod|END_ENTITY	Activation of NF-kappaB by fluid_shear_stress , but not TNF-alpha , requires focal_adhesion_kinase in osteoblasts .
10400703	0	focal_adhesion_kinase	23,44	PTEN	0,4	focal adhesion kinase	PTEN	14083(Tax:10090)	19211(Tax:10090)	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	PTEN interactions with focal_adhesion_kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway .
19501627	0	focal_adhesion_kinase	50,71	PTEN	0,4	focal adhesion kinase	PTEN	14083(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PTEN and SHIP2 regulates PI3K/Akt pathway through focal_adhesion_kinase .
9927060	0	focal_adhesion_kinase	102,123	PTEN	17,21	focal adhesion kinase	PTEN	5747	5728	Gene	Gene	involvement|nmod|START_ENTITY inhibition|dep|involvement inhibition|compound|END_ENTITY	Tumor suppressor PTEN inhibition of cell invasion , migration , and growth : differential involvement of focal_adhesion_kinase and p130Cas .
12231407	0	focal_adhesion_kinase	68,89	Pyk2	40,44	focal adhesion kinase	Pyk2	14083(Tax:10090)	2185	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal_adhesion_kinase in osteoclasts .
9402324	0	focal_adhesion_kinase	30,51	RAFTK	52,57	focal adhesion kinase	RAFTK	5747	2185	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization of the novel focal_adhesion_kinase RAFTK in hematopoietic cells .
15657578	0	focal_adhesion_kinase	20,41	RET	0,3	focal adhesion kinase	RET	14083(Tax:10090)	19713(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	RET signals through focal_adhesion_kinase in medullary_thyroid_cancer cells .
10208419	0	focal_adhesion_kinase	59,80	Ret	115,118	focal adhesion kinase	Ret	5747	5979	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Rho-dependent and - independent tyrosine phosphorylation of focal_adhesion_kinase , paxillin and p130Cas mediated by Ret kinase .
16690621	0	focal_adhesion_kinase	45,66	SHP2	37,41	focal adhesion kinase	SHP2	25614(Tax:10116)	25622(Tax:10116)	Gene	Gene	down-regulation|amod|START_ENTITY END_ENTITY|nmod|down-regulation	Role of protein-tyrosine phosphatase SHP2 in focal_adhesion_kinase down-regulation during neutrophil cathepsin_G-induced cardiomyocytes anoikis .
23512980	0	focal_adhesion_kinase	40,61	SHP2	25,29	focal adhesion kinase	SHP2	5747	5781	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	The tyrosine phosphatase SHP2 regulates focal_adhesion_kinase to promote EGF-induced lamellipodia persistence and cell migration .
24952416	0	focal_adhesion_kinase	41,62	Shb	27,30	focal adhesion kinase	Shb	5747	6461	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	The Src homology-2 protein Shb modulates focal_adhesion_kinase signaling in a BCR-ABL myeloproliferative_disorder causing accelerated progression of disease .
24344332	0	focal_adhesion_kinase	80,101	Teneurin-4	0,10	focal adhesion kinase	Teneurin-4	14083(Tax:10090)	23966(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal_adhesion_kinase signaling .
10905491	0	focal_adhesion_kinase	163,184	Tumor_necrosis_factor-alpha	0,27	focal adhesion kinase	Tumor necrosis factor-alpha	25614(Tax:10116)	24835(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces hepatic insulin resistance in obese Zucker -LRB- fa/fa -RRB- rats via interaction of leukocyte_antigen-related_tyrosine_phosphatase with focal_adhesion_kinase .
17438336	0	focal_adhesion_kinase	39,60	Tumor_necrosis_factor-alpha	0,27	focal adhesion kinase	Tumor necrosis factor-alpha	5747	7124	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Tumor_necrosis_factor-alpha stimulates focal_adhesion_kinase activity required for mitogen-activated kinase-associated interleukin_6 expression .
22734001	0	focal_adhesion_kinase	18,39	VCAM-1	63,69	focal adhesion kinase	VCAM-1	5747	7412	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Nuclear-localized focal_adhesion_kinase regulates inflammatory VCAM-1 expression .
12844492	0	focal_adhesion_kinase	142,163	Vascular_endothelial_growth_factor	0,34	focal adhesion kinase	Vascular endothelial growth factor	5747	7422	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal_adhesion_kinase and related_adhesion_focal_tyrosine_kinase .
10804218	0	focal_adhesion_kinase	36,57	beta_1_integrin	15,30	focal adhesion kinase	beta 1 integrin	5747	3688	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of beta_1_integrin with focal_adhesion_kinase and paxillin in differentiating Schwann cells .
17028776	0	focal_adhesion_kinase	108,129	cancer-associated_gene	22,44	focal adhesion kinase	cancer-associated gene	5747	168400	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Cancer/testis antigen cancer-associated_gene -LRB- CAGE -RRB- promotes motility of cancer cells through activation of focal_adhesion_kinase -LRB- FAK -RRB- .
24565837	0	focal_adhesion_kinase	127,148	caspase-3	76,85	focal adhesion kinase	caspase-3	5747	836	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Saikosaponin_C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal_adhesion_kinase in human umbilical vein endothelial cells .
11912174	0	focal_adhesion_kinase	115,136	caspase_3	80,89	focal adhesion kinase	caspase 3	5747	836	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase_3 activity and cleavage of focal_adhesion_kinase .
14603053	0	focal_adhesion_kinase	14,35	focal_adhesion_kinase	55,76	focal adhesion kinase	focal adhesion kinase	5747	5747	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of focal_adhesion_kinase and phosphorylated focal_adhesion_kinase in squamous_cell_carcinoma_of_the_larynx .
14603053	0	focal_adhesion_kinase	55,76	focal_adhesion_kinase	14,35	focal adhesion kinase	focal adhesion kinase	5747	5747	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of focal_adhesion_kinase and phosphorylated focal_adhesion_kinase in squamous_cell_carcinoma_of_the_larynx .
17931358	0	focal_adhesion_kinase	43,64	lysyl_oxidase	7,20	focal adhesion kinase	lysyl oxidase	5747	4015	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Active lysyl_oxidase -LRB- LOX -RRB- correlates with focal_adhesion_kinase -LRB- FAK -RRB- / paxillin activation and migration in invasive astrocytes .
11496289	0	focal_adhesion_kinase	22,43	p125FAK	45,52	focal adhesion kinase	p125FAK	5747	14083(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the focal_adhesion_kinase -LRB- p125FAK -RRB- in the vascular smooth muscle cells of intimal_hyperplasia .
7796399	0	focal_adhesion_kinase	22,43	p125FAK	45,52	focal adhesion kinase	p125FAK	5747	5747	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the focal_adhesion_kinase -LRB- p125FAK -RRB- in invasive human tumors .
12702722	0	focal_adhesion_kinase	22,43	p190RhoGEF	49,59	focal adhesion kinase	p190RhoGEF	14083(Tax:10090)	110596;16800	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of focal_adhesion_kinase with p190RhoGEF .
26071201	0	focal_adhesion_kinase	23,44	p70S6K	0,6	focal adhesion kinase	p70S6K	14083(Tax:10090)	72508(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	p70S6K is regulated by focal_adhesion_kinase and is required for Src-selective autophagy .
9439602	0	focal_adhesion_kinase	36,57	substance_P	89,100	focal adhesion kinase	substance P	5747	6863	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of phosphorylation of focal_adhesion_kinase and paxillin by combination of substance_P and IGF-1 in SV-40 transformed human corneal_epithelial cells .
17202889	0	focal_adhesion_kinase	77,98	tumor_necrosis_factor-alpha	8,35	focal adhesion kinase	tumor necrosis factor-alpha	5747	7124	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Role of tumor_necrosis_factor-alpha , interleukin-8 , and dexamethasone in the focal_adhesion_kinase expression by human nucleus pulposus cells .
9733596	0	focal_adhesion_kinase	96,117	tyrosine_kinase	63,78	focal adhesion kinase	tyrosine kinase	5747	7294	Gene	Gene	signals|compound|START_ENTITY signals|amod|END_ENTITY	Human Caco-2 intestinal epithelial motility is associated with tyrosine_kinase and cytoskeletal focal_adhesion_kinase signals .
11696015	0	focal_adhesion_kinase	89,110	vascular_endothelial_growth_factor	28,62	focal adhesion kinase	vascular endothelial growth factor	5747	7422	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	Src mediates stimulation by vascular_endothelial_growth_factor of the phosphorylation of focal_adhesion_kinase at tyrosine 861 , and migration and anti-apoptosis in endothelial cells .
11927607	0	focal_adhesion_kinase	25,46	vascular_endothelial_growth_factor	76,110	focal adhesion kinase	vascular endothelial growth factor	14083(Tax:10090)	22339(Tax:10090)	Gene	Gene	beta5|amod|START_ENTITY coupling|nmod|beta5 coupling|nmod|signaling signaling|compound|END_ENTITY	Src-mediated coupling of focal_adhesion_kinase to integrin alpha -LRB- v -RRB- beta5 in vascular_endothelial_growth_factor signaling .
23518909	0	folate_receptor-a	14,31	FRA	33,36	folate receptor-a	FRA	8061	8061	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of folate_receptor-a -LRB- FRA -RRB- in gynecologic malignancies and its relationship to the tumor type .
8869593	0	follicle-stimulating_hormone	51,79	FSH	81,84	follicle-stimulating hormone	FSH	14308(Tax:10090)	14308(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Pituitary and ovarian expression of the endogenous follicle-stimulating_hormone -LRB- FSH -RRB- subunit genes and an FSH_beta-subunit promoter-driven herpes simplex virus thymidine kinase gene in transgenic_mice ; specific partial ablation of FSH-producing cells by antiherpes treatment .
12088867	0	follicle-stimulating_hormone-beta	43,76	PACAP	14,19	follicle-stimulating hormone-beta	PACAP	25447(Tax:10116)	24166(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|dobj|levels	Evidence that PACAP and GnRH down-regulate follicle-stimulating_hormone-beta mRNA levels by stimulating follistatin gene expression : effects on folliculostellate cells , gonadotrophs and LbetaT2 gonadotroph cells .
19357364	0	follicle-stimulating_hormone_beta	25,58	GNRH1	16,21	follicle-stimulating hormone beta	GNRH1	14308(Tax:10090)	14714(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Rapid effect of GNRH1 on follicle-stimulating_hormone_beta gene expression in LbetaT2 mouse pituitary cells requires the progesterone_receptor .
15625767	0	follicle-stimulating_hormone_receptor	6,43	FSH-R	45,50	follicle-stimulating hormone receptor	FSH-R	2492	2492	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Human follicle-stimulating_hormone_receptor -LRB- FSH-R -RRB- promoter/enhancer activity is inhibited by transcriptional factors , from the upstream stimulating factors family , via E-box and newly identified initiator element -LRB- Inr -RRB- in FSH-R non-expressing cells .
20087398	0	follicle-stimulating_hormone_receptor	64,101	FSHR	103,107	follicle-stimulating hormone receptor	FSHR	2492	2492	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An unbalanced translocation unmasks a recessive mutation in the follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene and causes FSH resistance .
20420197	0	follicle-stimulating_hormone_receptor	14,51	FSHR	53,57	follicle-stimulating hormone receptor	FSHR	2492	2492	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- mRNA in the ovary of Zi geese during developmental and egg laying stages .
21865747	0	follicle-stimulating_hormone_receptor	30,67	FSHR	74,78	follicle-stimulating hormone receptor	FSHR	2492	2492	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Influence of variation in the follicle-stimulating_hormone_receptor gene -LRB- FSHR -RRB- and age at menopause on the development of Alzheimer 's _ disease in women .
23086931	0	follicle-stimulating_hormone_receptor	125,162	FSHR	164,168	follicle-stimulating hormone receptor	FSHR	2492	2492	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sertoli cell-specific expression of metastasis-associated_protein_2 -LRB- MTA2 -RRB- is required for transcriptional regulation of the follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene during spermatogenesis .
25365857	0	follicle-stimulating_hormone_receptor	30,67	FSHR	74,78	follicle-stimulating hormone receptor	FSHR	2492	2492	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Asn680ser polymorphism of the follicle-stimulating_hormone_receptor gene -LRB- FSHR -RRB- is not associated with recurrent_pregnancy_loss -LRB- RPL -RRB- .
8432542	0	follicle-stimulating_hormone_receptor	42,79	FSHR	86,90	follicle-stimulating hormone receptor	FSHR	2492	2492	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The chromosomal localization of the human follicle-stimulating_hormone_receptor gene -LRB- FSHR -RRB- on 2p21-p16 is similar to that of the luteinizing hormone receptor gene .
8661143	0	follicle-stimulating_hormone_receptor	44,81	FSHR	83,87	follicle-stimulating hormone receptor	FSHR	2492	2492	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The structure and organization of the human follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene .
9773974	0	follicle-stimulating_hormone_receptor	57,94	FSHR	96,100	follicle-stimulating hormone receptor	FSHR	25449(Tax:10116)	25449(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple promoter elements contribute to activity of the follicle-stimulating_hormone_receptor -LRB- FSHR -RRB- gene in testicular Sertoli cells .
10642569	0	follicle-stimulating_hormone_receptor	43,80	insulin-like_growth_factor_I	10,38	follicle-stimulating hormone receptor	insulin-like growth factor I	25449(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A role of insulin-like_growth_factor_I for follicle-stimulating_hormone_receptor expression in rat granulosa cells .
10632421	0	follicle-stimulating_hormone_receptor	23,60	prolactin	10,19	follicle-stimulating hormone receptor	prolactin	2492	5617	Gene	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of prolactin on follicle-stimulating_hormone_receptor binding and progesterone production in cultured porcine granulosa cells .
16711022	0	follicle-stimulating_hormone_receptor	45,82	proliferating_cell_nuclear_antigen	104,138	follicle-stimulating hormone receptor	proliferating cell nuclear antigen	2492	5111	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of antisense oligodeoxynucleotide to follicle-stimulating_hormone_receptor on the expression of proliferating_cell_nuclear_antigen and vascular_endothelial_growth_factor in primary culture cells derived from human ovarian_mucinous_cystadenocarcinoma .
11328853	0	follicle-stimulating_hormone_receptor	22,59	steroidogenic_factor_1	72,94	follicle-stimulating hormone receptor	steroidogenic factor 1	25449(Tax:10116)	117855(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Activation of the rat follicle-stimulating_hormone_receptor promoter by steroidogenic_factor_1 is blocked by protein kinase a and requires upstream stimulatory factor binding to a proximal E box element .
19552818	0	follicle_stimulating_hormone_beta	24,57	Activin_A	0,9	follicle stimulating hormone beta	Activin A	25447(Tax:10116)	29200(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Activin_A induces ovine follicle_stimulating_hormone_beta using -169 / -58 bp of its promoter and a simple TATA box .
18573707	0	folliculin	78,88	FLCN	90,94	folliculin	FLCN	201163	201163	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Birt-Hogg-Dub ___ -LRB- BHD -RRB- _ syndrome : report of two novel germline mutations in the folliculin -LRB- FLCN -RRB- gene .
19802896	0	folliculin	58,68	FLCN	70,74	folliculin	FLCN	201163	201163	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new locus-specific database -LRB- LSDB -RRB- for mutations in the folliculin -LRB- FLCN -RRB- gene .
8243277	0	follistatin	20,31	Activin-A	0,9	follistatin	Activin-A	24373(Tax:10116)	29200(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells .
9178255	0	follistatin	41,52	BMP-4	73,78	follistatin	BMP-4	14313(Tax:10090)	12159(Tax:10090)	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4 .
16943576	0	follistatin	73,84	FSHbeta	15,22	follistatin	FSHbeta	24373(Tax:10116)	25447(Tax:10116)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Stimulation of FSHbeta transcription by blockade of endogenous pituitary follistatin production : Efficacy of adenoviral-delivered antisense RNA in the rat .
23265961	0	follistatin	25,36	FST	38,41	follistatin	FST	10468	10468	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Quantitative analysis of follistatin -LRB- FST -RRB- promoter methylation in peripheral blood of patients with polycystic_ovary_syndrome .
19106105	0	follistatin	38,49	FoxL2	0,5	follistatin	FoxL2	14313(Tax:10090)	26927(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	FoxL2 and Smad3 coordinately regulate follistatin gene transcription .
8886627	0	follistatin	38,49	LHRH	11,15	follistatin	LHRH	24373(Tax:10116)	25194(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of LHRH , FSH and activin_A on follistatin secretion from cultured rat anterior pituitary cells .
7600958	0	follistatin	139,150	activin	113,120	follistatin	activin	14313(Tax:10090)	83729	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Expression of inhibin subunits and follistatin during postimplantation mouse development : decidual expression of activin and expression of follistatin in primitive streak , somites and hindbrain .
1704219	0	follistatin	48,59	activin-binding_protein	23,46	follistatin	activin-binding protein	399282(Tax:8355)	399282(Tax:8355)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|mRNA mRNA|nmod|END_ENTITY	Expression of mRNA for activin-binding_protein -LRB- follistatin -RRB- during early embryonic development of Xenopus_laevis .
18319260	0	follistatin	94,105	bone_morphogenetic_protein	48,74	follistatin	bone morphogenetic protein	10468	649	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	GLI2-specific transcriptional activation of the bone_morphogenetic_protein / activin antagonist follistatin in human epidermal cells .
1906804	0	follistatin	129,140	follistatin	32,43	follistatin	follistatin	10468	10468	Gene	Gene	comparison|nmod|START_ENTITY expression|dep|comparison expression|nmod|END_ENTITY	Recombinant expression of human follistatin with 315 and 288 amino_acids : chemical and biological comparison with native porcine follistatin .
1906804	0	follistatin	32,43	follistatin	129,140	follistatin	follistatin	10468	10468	Gene	Gene	expression|nmod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	Recombinant expression of human follistatin with 315 and 288 amino_acids : chemical and biological comparison with native porcine follistatin .
15130517	0	follistatin-related_gene	38,62	FLRG	64,68	follistatin-related gene	FLRG	10272	10272	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Human endometrium and decidua express follistatin-related_gene -LRB- FLRG -RRB- mRNA and peptide .
17069759	0	follitropin_receptor	70,90	GDNF	22,26	follitropin receptor	GDNF	14309(Tax:10090)	14573(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Age-dependent bimodal GDNF regulation during ovarian_tumorigenesis in follitropin_receptor mutant mice .
24398995	0	folr1	48,53	COL6A3	68,74	folr1	COL6A3	395638(Tax:9031)	396548(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	folr1	48,53	EDNRB	76,81	folr1	EDNRB	395638(Tax:9031)	408082(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	folr1	48,53	IGF2R	55,60	folr1	IGF2R	395638(Tax:9031)	395817(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	folr1	48,53	KLF6	83,87	folr1	KLF6	395638(Tax:9031)	420463(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
24398995	0	folr1	48,53	RGS2	62,66	folr1	RGS2	395638(Tax:9031)	378912(Tax:9031)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Valproic_acid substantially downregulated genes folr1 , IGF2R , RGS2 , COL6A3 , EDNRB , KLF6 , and pax-3 , N-acetylcysteine alleviated most of the induced gene alterations in chicken embryo model .
15477465	0	forkhead_box_C1	49,64	FOXC1	66,71	forkhead box C1	FOXC1	2296	2296	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Axenfeld-Rieger_anomaly : a novel mutation in the forkhead_box_C1 -LRB- FOXC1 -RRB- gene in a 4-generation family .
25738520	0	forkhead_box_F2_transcription_factor	55,91	miR-182	0,7	forkhead box F2 transcription factor	miR-182	2295	406958	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-182 promotes cell growth and invasion by targeting forkhead_box_F2_transcription_factor in colorectal_cancer .
24412290	0	forkhead_box_G1	18,33	FOXG1	35,40	forkhead box G1	FOXG1	2290	2290	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutation in forkhead_box_G1 -LRB- FOXG1 -RRB- gene in an Indian patient with Rett_syndrome .
26790640	0	forkhead_box_M1	95,110	FBXL2	14,19	forkhead box M1	FBXL2	2305	25827	Gene	Gene	degradation|nmod|START_ENTITY inhibits|nmod|degradation inhibits|nsubj|END_ENTITY	F-box protein FBXL2 inhibits gastric_cancer proliferation by ubiquitin-mediated degradation of forkhead_box_M1 .
26022336	0	forkhead_box_M1	13,28	FoxM1	30,35	forkhead box M1	FoxM1	2305	2305	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of forkhead_box_M1 -LRB- FoxM1 -RRB- by EGF through ERK signaling pathway promotes trophoblast cell invasion .
20033803	0	forkhead_box_O1	10,25	FOXO1	27,32	forkhead box O1	FOXO1	2308	2308	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of forkhead_box_O1 -LRB- FOXO1 -RRB- on beta cell development in the human fetal pancreas .
22504457	0	forkhead_box_P2	49,64	FOXP2	66,71	forkhead box P2	FOXP2	93986	93986	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An association study of sequence variants in the forkhead_box_P2 -LRB- FOXP2 -RRB- gene and adulthood attention-deficit/hyperactivity _ disorder in two European samples .
18505426	0	forkhead_box_P3	13,28	CD4	39,42	forkhead box P3	CD4	50943	920	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Reduction of forkhead_box_P3 levels in CD4 + CD25high T cells in patients with new-onset systemic_lupus_erythematosus .
21791023	0	forkhead_box_P3	19,34	CD4	14,17	forkhead box P3	CD4	50943	920	Gene	Gene	START_ENTITY|nummod|+ +|compound|END_ENTITY	Expression of CD4 + forkhead_box_P3 -LRB- FOXP3 -RRB- + regulatory T cells in inflammatory_bowel_disease .
21985361	0	forkhead_box_P3	145,160	CD4	140,143	forkhead box P3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Chronic_lymphocytic_leukaemia cells drive the global CD4 + T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4 + forkhead_box_P3 + T cells .
23375290	0	forkhead_box_p3	42,57	CD4	25,28	forkhead box p3	CD4	50943	920	Gene	Gene	T|nsubj|START_ENTITY affect|dep|T affect|dobj|CD25 CD25|compound|END_ENTITY	Sirolimus did not affect CD4 -LRB- + -RRB- CD25 -LRB- high -RRB- forkhead_box_p3 -LRB- + -RRB- T cells of peripheral blood in renal transplant recipients .
23607606	0	forkhead_box_protein_3	51,73	FoxP3	75,80	forkhead box protein 3	FoxP3	50943	50943	Gene	Gene	+|amod|START_ENTITY +|appos|END_ENTITY	Thymus transplantation restores the repertoires of forkhead_box_protein_3 -LRB- FoxP3 -RRB- + and FoxP3 - T cells in complete_DiGeorge_anomaly .
23347700	0	forkhead_box_protein_O1	23,46	FoxO1	48,53	forkhead box protein O1	FoxO1	2308	2308	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elevated expression of forkhead_box_protein_O1 -LRB- FoxO1 -RRB- in alcohol-induced intestinal_barrier_dysfunction .
9119367	0	formin	10,16	Fmn	18,21	formin	Fmn	14260(Tax:10090)	14260(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse formin -LRB- Fmn -RRB- gene : genomic structure , novel exons , and genetic mapping .
9848078	0	formin	10,16	Fmn	18,21	formin	Fmn	14260(Tax:10090)	14260(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse formin -LRB- Fmn -RRB- gene : abundant circular RNA transcripts and gene-targeted deletion analysis .
15866570	0	formin-2	52,60	FMN2	62,66	formin-2	FMN2	56776	56776	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization and mutation analysis of the human formin-2 -LRB- FMN2 -RRB- gene in women with unexplained_infertility .
21782780	0	formyl_peptide_receptor	97,120	Annexin_1	0,9	formyl peptide receptor	Annexin 1	2357	301	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Annexin_1 released by necrotic human glioblastoma cells stimulates tumor cell growth through the formyl_peptide_receptor 1 .
12377930	0	formyl_peptide_receptor-like_1	22,52	FPRL1	54,59	formyl peptide receptor-like 1	FPRL1	2358	2358	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role of the formyl_peptide_receptor-like_1 -LRB- FPRL1 -RRB- in inflammatory aspects of Alzheimer 's _ disease .
11160182	0	formyl_peptide_receptor-like_1	111,141	PrP	38,41	formyl peptide receptor-like 1	PrP	2358	5621	Gene	Gene	agonist|nmod|START_ENTITY agonist|nsubj|END_ENTITY	The neurotoxic prion peptide fragment PrP -LRB- 106-126 -RRB- is a chemotactic agonist for the G protein-coupled receptor formyl_peptide_receptor-like_1 .
25109685	0	formyl_peptide_receptor_1	38,63	FAM19A4	0,7	formyl peptide receptor 1	FAM19A4	2357	151647	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	FAM19A4 is a novel cytokine ligand of formyl_peptide_receptor_1 -LRB- FPR1 -RRB- and is able to promote the migration and phagocytosis of macrophages .
23185575	0	formyl_peptide_receptor_1	18,43	FPR1	45,49	formyl peptide receptor 1	FPR1	2357	2357	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of the formyl_peptide_receptor_1 -LRB- FPR1 -RRB- gene in primary human macrophages .
16237106	0	formyl_peptide_receptor_2	38,63	IL-4	0,4	formyl peptide receptor 2	IL-4	14289(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IL-4 inhibits the expression of mouse formyl_peptide_receptor_2 , a receptor for amyloid beta1-42 , in TNF-alpha-activated microglia .
17984291	0	formyl_peptide_receptor_like-1	114,144	Serum_amyloid_A	0,15	formyl peptide receptor like-1	Serum amyloid A	2358	6287	Gene	Gene	independent|nmod|START_ENTITY mediates|nmod|independent mediates|nsubj|END_ENTITY	Serum_amyloid_A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl_peptide_receptor_like-1 .
21216225	0	formylpeptide_receptor	21,43	FPR1	50,54	formylpeptide receptor	FPR1	2357	2357	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the formylpeptide_receptor gene -LRB- FPR1 -RRB- and susceptibility to stomach_cancer in 1531 consecutive autopsy cases .
18325344	0	fortilin	20,28	TSC-22	86,92	fortilin	TSC-22	7178	8848	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction between fortilin and transforming_growth_factor-beta_stimulated_clone-22 -LRB- TSC-22 -RRB- prevents apoptosis via the destabilization of TSC-22 .
21179765	0	fos	127,130	CA1	165,168	fos	CA1	2353	759	Gene	Gene	expressions|nmod|START_ENTITY expressions|nmod|area area|compound|END_ENTITY	-LSB- The relationship between the effects of curcumin on cerebral_ischemia / reperfusion injury and immediately genic expressions of fos , Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils -RSB- .
15812575	0	fos	14,17	CSF-1	0,5	fos	CSF-1	14281(Tax:10090)	12977(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	CSF-1 induces fos gene transcription and activates the transcription factor Elk-1 in mature osteoclasts .
9888853	0	fos	67,70	DNA_5-methylcytosine_transferase	8,40	fos	DNA 5-methylcytosine transferase	2353	1786	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of DNA_5-methylcytosine_transferase in cell transformation by fos .
12522005	0	fos	87,90	Hematopoietic_progenitor_kinase_1	0,33	fos	Hematopoietic progenitor kinase 1	2353	11184	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Hematopoietic_progenitor_kinase_1 -LRB- HPK1 -RRB- negatively regulates prostaglandin_E2-induced fos gene transcription .
18757399	0	fos	22,25	Podoplanin	0,10	fos	Podoplanin	14281(Tax:10090)	14726(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Podoplanin is a novel fos target gene in skin_carcinogenesis .
2693038	0	fos	33,36	c-fos	38,43	fos	c-fos	100144486(Tax:9823)	100144486(Tax:9823)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the proto-oncogene fos -LRB- c-fos -RRB- by preimplantation blastocysts of the pig .
18514175	0	fos	45,48	ghrelin	29,36	fos	ghrelin	314322(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|delivery delivery|nmod|END_ENTITY	Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract , but not in the arcuate or paraventricular nuclei of the hypothalamus .
15387548	0	fos	90,93	jun	36,39	fos	jun	2353	3725	Gene	Gene	peptides|compound|START_ENTITY displaying|dobj|peptides dendrimer|acl|displaying peptides|nmod|dendrimer peptides|nsubj|assembly assembly|nmod|END_ENTITY	Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides .
1923517	0	fos	46,49	jun	14,17	fos	jun	396512(Tax:9031)	424673(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY transformation|nmod|gene transformation|compound|END_ENTITY	Inhibition of jun transformation by a mutated fos gene : design of an anti-oncogene .
21559685	0	fos	30,33	jun	35,38	fos	jun	2353	3725	Gene	Gene	gli|appos|START_ENTITY study|nmod|gli END_ENTITY|nsubj|study	A study on the oncogenes gli , fos , jun and met in human uterine leiomyomas .
2140597	0	fos	43,46	vimentin	6,14	fos	vimentin	14281(Tax:10090)	22352(Tax:10090)	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Mouse vimentin : structural relationship to fos , jun , CREB and tpr .
19828354	0	fos-B	7,12	C-fos	0,5	fos-B	C-fos	14282(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	C-fos , fos-B , c-jun and dusp-1 expression in the mouse heart after single and repeated methamphetamine administration .
7914658	0	fos-related_antigen	17,36	FRA	38,41	fos-related antigen	FRA	80754(Tax:10116)	80754(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of a 35 kDa fos-related_antigen -LRB- FRA -RRB- in the long-term induction of striatal dynorphin expression in the 6-hydroxydopamine lesioned rat .
9826775	0	fosB	23,27	Nrf1	0,4	fosB	Nrf1	14282(Tax:10090)	18181(Tax:10090)	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Nrf1 in a complex with fosB , c-jun , junD and ATF2 forms the AP1 component at the TNF_alpha promoter in stimulated mast cells .
9204924	0	fosB	134,138	fos-related_antigen	42,61	fosB	fos-related antigen	14282(Tax:10090)	70314(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY brains|nmod|mice activity|nmod|brains activity|amod|END_ENTITY	Absence of a persistently elevated 37 kDa fos-related_antigen and AP-1-like DNA-binding activity in the brains of kainic_acid-treated fosB null mice .
19298454	0	fou2	4,8	TPC1	55,59	fou2	TPC1	825655(Tax:3702)	825655(Tax:3702)	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	The fou2 mutation in the major vacuolar cation channel TPC1 confers tolerance to inhibitory luminal calcium .
23212909	0	four_and_a_half_LIM-only_protein_2	4,38	transforming_growth_factor_b	56,84	four and a half LIM-only protein 2	transforming growth factor b	2274	7040	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The four_and_a_half_LIM-only_protein_2 -LRB- FHL2 -RRB- activates transforming_growth_factor_b -LRB- TGF-b -RRB- signaling by regulating ubiquitination of the E3 ligase Arkadia .
20607723	0	four_and_half_lim_2	20,39	FHL2	41,45	four and half lim 2	FHL2	2274	2274	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Sp1 upregulates the four_and_half_lim_2 -LRB- FHL2 -RRB- expression in gastrointestinal_cancers through transcription regulation .
20607723	0	four_and_half_lim_2	20,39	Sp1	0,3	four and half lim 2	Sp1	2274	6667	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Sp1 upregulates the four_and_half_lim_2 -LRB- FHL2 -RRB- expression in gastrointestinal_cancers through transcription regulation .
19570850	0	foxd3	16,21	Disc1	0,5	foxd3	Disc1	30548(Tax:7955)	407621(Tax:7955)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Disc1 regulates foxd3 and sox10 expression , affecting neural crest migration and differentiation .
24116161	0	foxd3	21,26	Grb2	0,4	foxd3	Grb2	15221(Tax:10090)	14784(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin .
23900542	0	foxd3	26,31	Prdm1a	0,6	foxd3	Prdm1a	30548(Tax:7955)	323473(Tax:7955)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification .
16963235	0	foxe3	10,15	pitx3	77,82	foxe3	pitx3	570855(Tax:7955)	402974(Tax:7955)	Gene	Gene	START_ENTITY|dep|roles roles|nmod|morphogenesis morphogenesis|nmod|interaction interaction|nmod|END_ENTITY	Zebrafish foxe3 : roles in ocular lens morphogenesis through interaction with pitx3 .
22110345	0	foxg1	36,41	mss4	64,68	foxg1	mss4	24370(Tax:10116)	304807(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	A winged-helix transcription factor foxg1 induces expression of mss4 gene in rat hippocampal progenitor cells .
18282273	0	foxp3	14,19	CD25	9,13	foxp3	CD25	50943	3559	Gene	Gene	cell|amod|START_ENTITY determine|nsubj|cell +|ccomp|determine +|nsubj|END_ENTITY	Does CD4 + CD25 + foxp3 + cell -LRB- Treg -RRB- and IL-10 profile determine susceptibility to immune reconstitution inflammatory_syndrome -LRB- IRIS -RRB- in HIV_disease ?
18282273	0	foxp3	14,19	CD4	5,8	foxp3	CD4	50943	920	Gene	Gene	cell|amod|START_ENTITY determine|nsubj|cell +|ccomp|determine +|nsubj|CD25 CD25|compound|END_ENTITY	Does CD4 + CD25 + foxp3 + cell -LRB- Treg -RRB- and IL-10 profile determine susceptibility to immune reconstitution inflammatory_syndrome -LRB- IRIS -RRB- in HIV_disease ?
19902068	0	foxp3	45,50	CD4	36,39	foxp3	CD4	50943	920	Gene	Gene	cells|amod|START_ENTITY +|dobj|cells +|nsubj|Expression Expression|nmod|markers markers|nmod|CD25 CD25|compound|END_ENTITY	Expression of markers of regulatory CD4 + CD25 + foxp3 + cells in atherosclerotic_plaques of human coronary arteries .
22194713	0	foxp3	14,19	CD4	112,115	foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY Deficiency|nmod|cells exacerbates|nsubj|Deficiency exacerbates|advcl|altering altering|dobj|proportions proportions|nmod|cells cells|compound|END_ENTITY	Deficiency of foxp3 regulatory T cells exacerbates autoimmune_arthritis by altering the synovial proportions of CD4 T cells and dendritic cells .
23874581	0	foxp3	147,152	CD4	142,145	foxp3	CD4	20371(Tax:10090)	12504(Tax:10090)	Gene	Gene	ICOS|compound|START_ENTITY ICOS|compound|END_ENTITY	Mesothelin virus-like particle immunization controls pancreatic_cancer growth through CD8 + T cell induction and reduction in the frequency of CD4 + foxp3 + ICOS - regulatory T cells .
23874581	0	foxp3	147,152	CD8	86,89	foxp3	CD8	20371(Tax:10090)	925	Gene	Gene	ICOS|compound|START_ENTITY frequency|nmod|ICOS controls|nmod|frequency controls|nmod|induction induction|compound|END_ENTITY	Mesothelin virus-like particle immunization controls pancreatic_cancer growth through CD8 + T cell induction and reduction in the frequency of CD4 + foxp3 + ICOS - regulatory T cells .
25238105	0	foxp3	50,55	Ctla-4	0,6	foxp3	Ctla-4	20371(Tax:10090)	12477(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY differentiation|nmod|cells modulates|dobj|differentiation modulates|nsubj|END_ENTITY	Ctla-4 modulates the differentiation of inducible foxp3 + treg cells but IL-10 mediates their function in experimental autoimmune encephalomyelitis .
20887202	0	foxp3	40,45	TGF-b	87,92	foxp3	TGF-b	20371(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|nsubj|START_ENTITY cells|nmod|END_ENTITY	Retinal pigment epithelial cells induce foxp3 -LRB- + -RRB- regulatory T cells via membrane-bound TGF-b .
12839939	0	fra-1	43,48	cd44	52,56	fra-1	cd44	25445(Tax:10116)	25406(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Microarray analysis and RNA silencing link fra-1 to cd44 and c-met expression in mesothelioma .
11316763	0	fra-2	31,36	Parathyroid_hormone	0,19	fra-2	Parathyroid hormone	14284(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates fra-2 expression in osteoblastic cells in vitro and in vivo .
17591524	0	fractalkine	19,30	CD16	62,66	fractalkine	CD16	6376	2214	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Elevated levels of fractalkine expression and accumulation of CD16 + monocytes in glomeruli of active lupus_nephritis .
12667665	0	fractalkine	32,43	CX3CL1	45,51	fractalkine	CX3CL1	6376	6376	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	CSF and serum levels of soluble fractalkine -LRB- CX3CL1 -RRB- in inflammatory_diseases_of_the_nervous_system .
12966591	0	fractalkine	24,35	CX3CL1	37,43	fractalkine	CX3CL1	6376	6376	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Proinflammatory role of fractalkine -LRB- CX3CL1 -RRB- in rheumatoid_arthritis .
15013759	0	fractalkine	42,53	CX3CL1	55,61	fractalkine	CX3CL1	6376	6376	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	TNF-alpha and IL-4 regulate expression of fractalkine -LRB- CX3CL1 -RRB- as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts .
23143793	0	fractalkine	17,28	CX3CL1	30,36	fractalkine	CX3CL1	6376	6376	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of fractalkine -LRB- CX3CL1 -RRB- in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium .
23261412	0	fractalkine	114,125	CX3CL1	127,133	fractalkine	CX3CL1	6376	6376	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine -LRB- CX3CL1 -RRB- levels in a large UK twins ' sample .
11870871	0	fractalkine	14,25	CX3CR1	53,59	fractalkine	CX3CR1	6376	1524	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of fractalkine -LRB- CX3CL1 -RRB- and its receptor , CX3CR1 , during acute_and_chronic_inflammation in the rodent CNS .
12076860	0	fractalkine	27,38	CX3CR1	56,62	fractalkine	CX3CR1	6376	1524	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Up-regulated expression of fractalkine and its receptor CX3CR1 during liver_injury in humans .
15974917	0	fractalkine	8,19	CX3CR1	101,107	fractalkine	CX3CR1	6376	1524	Gene	Gene	Role|nmod|START_ENTITY Role|dep|development development|nmod|antagonists antagonists|compound|END_ENTITY	Role of fractalkine -LRB- CX3CL1 -RRB- in regulating neuron-microglia interactions : development of viral-based CX3CR1 antagonists .
17241867	0	fractalkine	76,87	CX3CR1	24,30	fractalkine	CX3CR1	6376	1524	Gene	Gene	+|nmod|START_ENTITY +|nsubj|recruitment recruitment|nmod|END_ENTITY	Enhanced recruitment of CX3CR1 + T cells by mucosal endothelial cell-derived fractalkine in inflammatory_bowel_disease .
18424766	0	fractalkine	28,39	CX3CR1	49,55	fractalkine	CX3CR1	6376	1524	Gene	Gene	receptor|amod|START_ENTITY expression|nmod|receptor END_ENTITY|nsubj|expression	Decreased expression of the fractalkine receptor CX3CR1 on circulating monocytes as new feature of sepsis-induced immunosuppression .
20019415	0	fractalkine	16,27	CX3CR1	46,52	fractalkine	CX3CR1	6376	1524	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of fractalkine and its receptor , CX3CR1 , is associated with coronary plaque_rupture in patients with unstable angina_pectoris .
21527754	0	fractalkine	102,113	CX3CR1	80,86	fractalkine	CX3CR1	6376	1524	Gene	Gene	upregulating|nmod|START_ENTITY upregulating|dobj|END_ENTITY	Amyloid beta enhances migration of endothelial progenitor cells by upregulating CX3CR1 in response to fractalkine , which may be associated with development of choroidal_neovascularization .
22648046	0	fractalkine	24,35	CX3CR1	53,59	fractalkine	CX3CR1	6376	485599(Tax:9615)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Increased expression of fractalkine and its receptor CX3CR1 in canine inflammatory_bowel_disease and their possible role in recruitment of intraepithelial lymphocytes .
23125415	0	fractalkine	105,116	CX3CR1	137,143	fractalkine	CX3CR1	6376	1524	Gene	Gene	mutant|nmod|START_ENTITY antagonist|nsubj|mutant antagonist|nmod|END_ENTITY	Integrins avb3 and a4b1 act as coreceptors for fractalkine , and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1 .
24060055	0	fractalkine	111,122	CX3CR1	132,138	fractalkine	CX3CR1	6376	1524	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression Hypertrophy|acl|associated Hypertrophy|parataxis|chemokine chemokine|nsubj|END_ENTITY	Hypertrophy of the ligament flavum in degenerative_lumbar_stenosis associated with the increased expression of fractalkine -LRB- CX3CL1 -RRB- / CX3CR1 chemokine .
25420917	0	fractalkine	27,38	CX3CR1	40,46	fractalkine	CX3CR1	6376	1524	Gene	Gene	CX3CL1|appos|START_ENTITY Involvement|nmod|CX3CL1 Involvement|dep|pathway pathway|nummod|END_ENTITY	Involvement of the CX3CL1 -LRB- fractalkine -RRB- / CX3CR1 pathway in the pathogenesis of acute_graft-versus-host_disease .
26567742	0	fractalkine	140,151	CX3CR1	11,17	fractalkine	CX3CR1	6376	13051(Tax:10090)	Gene	Gene	Is|nsubj|START_ENTITY Is|dobj|Effects Effects|nmod|chemokines chemokines|compound|END_ENTITY	Effects of CX3CR1 and fractalkine chemokines in amyloid beta clearance and p-Tau accumulation in Alzheimer , s_disease -LRB- AD -RRB- rodent models : Is fractalkine a systemic biomarker for AD ?
11509334	0	fractalkine	28,39	Interferon-gamma	0,16	fractalkine	Interferon-gamma	6376	3458	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Interferon-gamma stimulates fractalkine expression in human bronchial epithelial cells and regulates mononuclear cell adherence .
24508784	0	fractalkine	142,153	TLR4	179,183	fractalkine	TLR4	6376	7099	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Subendothelial resistin enhances monocyte transmigration in a co-culture of human endothelial and smooth_muscle_cells by mechanisms involving fractalkine , MCP-1 and activation of TLR4 and Gi/o proteins signaling .
12631113	0	fractalkine	39,50	Tumor_necrosis_factor-alpha	0,27	fractalkine	Tumor necrosis factor-alpha	6376	7124	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Tumor_necrosis_factor-alpha stimulates fractalkine production by mesangial cells and regulates monocyte transmigration : down-regulation by cAMP .
11311510	0	fractalkine	81,92	tumor_necrosis_factor-alpha	28,55	fractalkine	tumor necrosis factor-alpha	6376	7124	Gene	Gene	expression|amod|START_ENTITY stimulation|nmod|expression stimulation|nmod|END_ENTITY	Synergistic stimulation , by tumor_necrosis_factor-alpha and interferon-gamma , of fractalkine expression in human astrocytes .
17804530	0	fractalkine_receptor	22,42	CD4	55,58	fractalkine receptor	CD4	1524	920	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Surface expression of fractalkine_receptor -LRB- CX3CR1 -RRB- on CD4 + / CD28 T cells in RA patients and correlation with atherosclerotic_damage .
12110009	0	fractalkine_receptor	18,38	CX3CR1	40,46	fractalkine receptor	CX3CR1	1524	1524	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the fractalkine_receptor -LRB- CX3CR1 -RRB- in human kidney_diseases .
12086643	0	fragile_X	11,20	DFXR	30,34	fragile X	DFXR	37528(Tax:7227)	37528(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Drosophila fragile_X protein , DFXR , regulates neuronal morphology and function in the brain .
12446764	0	fragile_X_mental_retardation_protein	36,72	Casein_kinase_II	0,16	fragile X mental retardation protein	Casein kinase II	37528(Tax:7227)	48448(Tax:7227)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Casein_kinase_II phosphorylates the fragile_X_mental_retardation_protein and modulates its biological properties .
22584570	0	fragile_X_mental_retardation_protein	51,87	TDP-43	29,35	fragile X mental retardation protein	TDP-43	2332	23435	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Neurodegeneration-associated TDP-43 interacts with fragile_X_mental_retardation_protein -LRB- FMRP -RRB- / Staufen -LRB- STAU1 -RRB- and regulates SIRT1 expression in neuronal cells .
10930803	0	fragile_histidine_triad	16,39	FHIT	41,45	fragile histidine triad	FHIT	2272	2272	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the fragile_histidine_triad -LRB- FHIT -RRB- gene in lobular breast_cancer .
12095833	0	fragile_histidine_triad	8,31	FHIT	33,37	fragile histidine triad	FHIT	2272	2272	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Loss of fragile_histidine_triad -LRB- FHIT -RRB- expression and microsatellite instability in periocular_sebaceous_gland_carcinoma in patients with Muir-Torre_syndrome .
16313263	0	fragile_histidine_triad	22,45	FHIT	47,51	fragile histidine triad	FHIT	2272	2272	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylation status of fragile_histidine_triad -LRB- FHIT -RRB- gene and its clinical impact on prognosis of patients with multiple_myeloma .
16343073	0	fragile_histidine_triad	53,76	FHIT	78,82	fragile histidine triad	FHIT	2272	2272	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter methylation and loss of coding exons of the fragile_histidine_triad -LRB- FHIT -RRB- gene in intrahepatic_cholangiocarcinomas .
17609851	0	fragile_histidine_triad	23,46	FHIT	48,52	fragile histidine triad	FHIT	2272	2272	Gene	Gene	association|nmod|START_ENTITY Lack|nmod|association Lack|appos|END_ENTITY	Lack of association of fragile_histidine_triad -LRB- FHIT -RRB- polymorphisms with lung_cancer in the Korean population .
18367246	0	fragile_histidine_triad	22,45	FHIT	47,51	fragile histidine triad	FHIT	2272	2272	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylation status of fragile_histidine_triad -LRB- FHIT -RRB- gene and its clinical impact on prognosis of patients with myelodysplastic_syndrome .
20083852	0	fragile_histidine_triad	22,45	FHIT	47,51	fragile histidine triad	FHIT	2272	2272	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Overexpression of the fragile_histidine_triad -LRB- FHIT -RRB- gene in inflammatory_bowel_disease .
10920977	0	fragile_histidine_triad_gene	16,44	FHIT	46,50	fragile histidine triad gene	FHIT	2272	2272	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	-LSB- Association of fragile_histidine_triad_gene -LRB- FHIT -RRB- with susceptibility to esophageal_cancer .
22411849	0	frataxin	50,58	Erythropoietin	0,14	frataxin	Erythropoietin	2395	2056	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Erythropoietin in Friedreich_ataxia : no effect on frataxin in a randomized controlled trial .
23839945	0	frataxin	35,43	Ferredoxin	0,10	frataxin	Ferredoxin	2395	2230	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Ferredoxin competes with bacterial frataxin in binding to the desulfurase IscS .
22171070	0	frataxin	21,29	HSC20	0,5	frataxin	HSC20	2395	150274	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis .
17322295	0	frataxin	102,110	Hypoxia-inducible_factor_2alpha	0,31	frataxin	Hypoxia-inducible factor 2alpha	14297(Tax:10090)	13819(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor_2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin .
17331979	0	frataxin	14,22	ISD11	38,43	frataxin	ISD11	2395	57128	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones .
22447512	0	frataxin	29,37	Interferon_gamma	0,16	frataxin	Interferon gamma	2395	3458	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Interferon_gamma upregulates frataxin and corrects the functional deficits in a Friedreich_ataxia model .
20808827	0	frataxin	20,28	SRF	67,70	frataxin	SRF	2395	6722	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of human frataxin is regulated by transcription factors SRF and TFAP2 .
12668611	0	frataxin	59,67	Yfh1	79,83	frataxin	Yfh1	2395	851437(Tax:4932)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Iron use for haeme synthesis is under control of the yeast frataxin homologue -LRB- Yfh1 -RRB- .
12165564	0	frataxin	10,18	Yfh1p	27,32	frataxin	Yfh1p	2395	851437(Tax:4932)	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins .
9180083	0	frataxin	78,86	Yfh1p	49,54	frataxin	Yfh1p	2395	851437(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Regulation of mitochondrial iron accumulation by Yfh1p , a putative homolog of frataxin .
18581197	0	frataxin	43,51	erythropoietin	18,32	frataxin	erythropoietin	2395	2056	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Recombinant human erythropoietin increases frataxin protein expression without increasing mRNA expression .
21597884	0	frataxin	29,37	erythropoietin	11,25	frataxin	erythropoietin	2395	2056	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Effects of erythropoietin on frataxin levels and mitochondrial function in Friedreich_ataxia -- a dose-response trial .
18063754	0	friend_of_GATA-1	42,58	FOG-1	60,65	friend of GATA-1	FOG-1	22761(Tax:10090)	22761(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Differential context-dependent effects of friend_of_GATA-1 -LRB- FOG-1 -RRB- on mast-cell development and differentiation .
19729519	0	friend_of_GATA-1	27,43	FOG-1	45,50	friend of GATA-1	FOG-1	407655(Tax:7955)	407655(Tax:7955)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role and regulation of friend_of_GATA-1 -LRB- FOG-1 -RRB- during blood development in the zebrafish .
10801815	0	friend_of_GATA-2	50,66	FOG-2	68,73	friend of GATA-2	FOG-2	23414	23414	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	A functionally conserved N-terminal domain of the friend_of_GATA-2 -LRB- FOG-2 -RRB- protein represses GATA4-dependent transcription .
17309641	0	friend_of_GATA_2	14,30	FOG-2	37,42	friend of GATA 2	FOG-2	23414	23414	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of friend_of_GATA_2 gene -LRB- FOG-2 -RRB- by a de novo t -LRB- 8 ; 10 -RRB- chromosomal translocation is associated with heart_defects and gonadal_dysgenesis .
14642436	0	frizzled-3	10,20	FZD3	22,26	frizzled-3	FZD3	7976	7976	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human frizzled-3 -LRB- FZD3 -RRB- gene on chromosome 8p21 , a receptor gene for Wnt ligands , is associated with the susceptibility to schizophrenia .
15657645	0	frizzled-3	25,35	FZD3	37,41	frizzled-3	FZD3	7976	7976	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of the frizzled-3 -LRB- FZD3 -RRB- gene with schizophrenia and mood_disorders .
15274031	0	frizzled_3	34,44	FZD3	46,50	frizzled 3	FZD3	7976	7976	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Positive association of the human frizzled_3 -LRB- FZD3 -RRB- gene haplotype with schizophrenia in Chinese Han population .
18256285	0	frizzled_7	95,105	syntenin	62,70	frizzled 7	syntenin	378787(Tax:8355)	447442(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled_7 and supports noncanonical Wnt signaling .
12031501	0	fructose_transporter	53,73	GLUT5	75,80	fructose transporter	GLUT5	56485(Tax:10090)	56485(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Cloning and functional characterization of the mouse fructose_transporter , GLUT5 .
24023717	0	fry	130,133	Mcs	149,152	fry	Mcs	304244(Tax:10116)	24899(Tax:10116)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Mapping of Mcs30 , a new mammary_carcinoma susceptibility quantitative trait locus -LRB- QTL30 -RRB- on rat chromosome 12 : identification of fry as a candidate Mcs gene .
2108665	0	ftz	77,80	fushi_tarazu	63,75	ftz	fushi tarazu	40834(Tax:7227)	40834(Tax:7227)	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of the Drosophila segmentation gene fushi_tarazu -LRB- ftz -RRB- ftz is one of the ` pair rule ' segmentation genes of Drosophila_melanogaster , and is an important component of the segmentation process in the fruit_fly .
24593306	0	fucosyltransferase_1	55,75	Calreticulin	0,12	fucosyltransferase 1	Calreticulin	2523	811	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Calreticulin activates b1 integrin via fucosylation by fucosyltransferase_1 in J82 human bladder_cancer cells .
17655580	0	fucosyltransferase_2	42,62	FUT2	64,68	fucosyltransferase 2	FUT2	2524	2524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Systematic sequence analysis of the human fucosyltransferase_2 -LRB- FUT2 -RRB- gene identifies novel sequence variations and alleles .
24130780	0	fucosyltransferase_8	24,44	FUT8	46,50	fucosyltransferase 8	FUT8	2530	2530	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of microRNAs on fucosyltransferase_8 -LRB- FUT8 -RRB- expression in hepatocarcinoma cells .
23039181	0	fucosyltransferase_VII	38,60	E-selectin	128,138	fucosyltransferase VII	E-selectin	14347(Tax:10090)	20339(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|END_ENTITY	Differential regulation and impact of fucosyltransferase_VII and core 2 b1,6-N-acetyl-glycosaminyltransferase for generation of E-selectin and P-selectin ligands in murine CD4 + T cells .
14695314	0	fumarate_hydratase	26,44	FH	46,48	fumarate hydratase	FH	2271	2271	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Biallelic inactivation of fumarate_hydratase -LRB- FH -RRB- occurs in nonsyndromic uterine leiomyomas but is rare in other tumors .
26173633	0	fumarate_hydratase	34,52	FH	54,56	fumarate hydratase	FH	2271	2271	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel splice site mutation in the fumarate_hydratase -LRB- FH -RRB- gene is associated with multiple cutaneous leiomyomas in a Japanese patient .
318155	0	fumarate_hydratase	23,41	FH	43,45	fumarate hydratase	FH	2271	2271	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Gene dosage effect for fumarate_hydratase -LRB- FH ; E.C. 4.2.1.2 -RRB- in partial trisomy 1 .
9707432	0	furin	38,43	BMP-4	0,5	furin	BMP-4	398345(Tax:8355)	399322(Tax:8355)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development .
21248358	0	furin	18,23	MEPE	0,4	furin	MEPE	5045	56955	Gene	Gene	activated|nmod|START_ENTITY END_ENTITY|acl|activated	MEPE activated by furin promotes pulpal cell adhesion .
21147780	0	furin	22,27	PCSK9	57,62	furin	PCSK9	18550(Tax:10090)	100102(Tax:10090)	Gene	Gene	inactivates|nsubj|START_ENTITY inactivates|dobj|END_ENTITY	In vivo evidence that furin from hepatocytes inactivates PCSK9 .
15527779	0	furin	14,19	Spn4A	30,35	furin	Spn4A	47220(Tax:7227)	49805(Tax:7227)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of furin by serpin Spn4A from Drosophila_melanogaster .
9109442	0	furin	64,69	TGFbeta1	0,8	furin	TGFbeta1	54281(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGFbeta1 regulates gene expression of its own converting enzyme furin .
20634490	0	furin	40,45	Transferrin_receptor_2	0,22	furin	Transferrin receptor 2	18550(Tax:10090)	50765(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Transferrin_receptor_2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular _ signal-regulated_kinase -LRB- MAPK/Erk -RRB- signaling .
9442015	0	furin	34,39	proteinase_inhibitor_8	49,71	furin	proteinase inhibitor 8	5045	5271	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of soluble recombinant furin by human proteinase_inhibitor_8 .
18539010	0	furrow	82,88	Hedgehog	0,8	furrow	Hedgehog	44654	42737(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Hedgehog and Dpp signaling induce cadherin_Cad86C expression in the morphogenetic furrow during Drosophila eye development .
22526020	0	fused_in_sarcoma	16,32	FUS	34,37	fused in sarcoma	FUS	2521	2521	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Localization of fused_in_sarcoma -LRB- FUS -RRB- protein to the post-synaptic density in the brain .
10744975	0	fushi_tarazu	46,58	Hox	71,74	fushi tarazu	Hox	40834(Tax:7227)	42536(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Evidence for the derivation of the Drosophila fushi_tarazu gene from a Hox gene orthologous to lophotrochozoan Lox5 .
2108665	0	fushi_tarazu	63,75	ftz	77,80	fushi tarazu	ftz	40834(Tax:7227)	40834(Tax:7227)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of the Drosophila segmentation gene fushi_tarazu -LRB- ftz -RRB- ftz is one of the ` pair rule ' segmentation genes of Drosophila_melanogaster , and is an important component of the segmentation process in the fruit_fly .
9677430	0	fyn	19,22	CD2	69,72	fyn	CD2	2534	914	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of p59 -LRB- fyn -RRB- with the T lymphocyte costimulatory receptor CD2 .
10562275	0	fyn	143,146	Protein_tyrosine_phosphatase_alpha	0,34	fyn	Protein tyrosine phosphatase alpha	2534	5786	Gene	Gene	linked|nmod|START_ENTITY complex|acl|linked form|dobj|complex form|nsubj|END_ENTITY	Protein_tyrosine_phosphatase_alpha -LRB- PTPalpha -RRB- and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn .
11093170	0	fyn	24,27	p59	20,23	fyn	p59	14360(Tax:10090)	72572(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A critical role for p59 -LRB- fyn -RRB- in CD2-based signal transduction .
9677430	0	fyn	19,22	p59	15,18	fyn	p59	2534	26003	Gene	Gene	Association|appos|START_ENTITY Association|nmod|END_ENTITY	Association of p59 -LRB- fyn -RRB- with the T lymphocyte costimulatory receptor CD2 .
1338328	0	fyn	62,65	p59fyn	75,81	fyn	p59fyn	25150(Tax:10116)	25150(Tax:10116)	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Purification and characterization of a possible protooncogene fyn product , p59fyn , from a rat brain particulate fraction .
21172064	0	fyn	69,72	prion_protein	52,65	fyn	prion protein	2534	5621	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Signal transduction in neurons : effects of cellular prion_protein on fyn kinase and ERK1/2 kinase .
12194827	0	fzr2	51,55	Cdh1	93,97	fzr2	Cdh1	37808(Tax:7227)	45922(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Completion of mitosis requires neither fzr/rap nor fzr2 , a male germline-specific Drosophila Cdh1 homolog .
12181756	0	g-csf	50,55	granulocyte_colony-stimulating_factor	11,48	g-csf	granulocyte colony-stimulating factor	25610(Tax:10116)	25610(Tax:10116)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of granulocyte_colony-stimulating_factor -LRB- g-csf -RRB- on neutrophil phagocytosis during experimental_obstructive_jaundice .
24993166	0	g0s2	14,18	TNF-a	0,5	g0s2	TNF-a	50486	7124	Gene	Gene	expression|amod|START_ENTITY reduces|dobj|expression reduces|nsubj|END_ENTITY	TNF-a reduces g0s2 expression and stimulates lipolysis through PPAR-y inhibition in 3T3-L1 adipocytes .
9330624	0	g6pd	59,63	glucose-6-phosphate_dehydrogenase	24,57	g6pd	glucose-6-phosphate dehydrogenase	14380(Tax:10090)	14380(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Somatic mutation of the glucose-6-phosphate_dehydrogenase -LRB- g6pd -RRB- gene in colonic stem cells and crypt restricted loss of G6PD activity .
23052251	0	gC1qR	48,53	C1q_receptor	34,46	gC1qR	C1q receptor	708	22918	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The role of the globular heads of C1q_receptor -LRB- gC1qR -RRB- gene in regulating apoptosis of human cervical_squamous_cell_carcinoma .
15163734	0	gC1qR	44,49	CD4	53,56	gC1qR	CD4	708	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Direct binding of hepatitis_C_virus core to gC1qR on CD4 + and CD8 + T cells leads to impaired activation of Lck and Akt .
19473882	0	gC1qR	13,18	CD4	19,22	gC1qR	CD4	708	920	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	Frequency of gC1qR + CD4 + T cells increases during acute hepatitis_C_virus infection and remains elevated in patients with chronic_infection .
20617170	0	gC1qR	17,22	CD4	26,29	gC1qR	CD4	708	920	Gene	Gene	engages|dobj|START_ENTITY engages|nmod|cells cells|compound|END_ENTITY	HIV gp41 engages gC1qR on CD4 + T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway .
19164550	0	gC1qR	61,66	RIG-I	14,19	gC1qR	RIG-I	708	23586	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria .
16458273	0	gabarap	25,32	lc3	78,81	gabarap	lc3	58974(Tax:10116)	25291(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY END_ENTITY|nsubj|distribution	Specific distribution of gabarap , gec1/gabarap Like 1 , gate16/gabarap Like 2 , lc3 messenger RNAs in rat brain areas by quantitative real-time PCR .
7558041	0	gad	41,44	gracile_axonal_dystrophy	15,39	gad	gracile axonal dystrophy	22223(Tax:10090)	22223(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mapping of the gracile_axonal_dystrophy -LRB- gad -RRB- gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5 .
10542372	0	gadd153	25,32	CHOP-10	16,23	gadd153	CHOP-10	13198(Tax:10090)	13198(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Upregulation of CHOP-10 -LRB- gadd153 -RRB- expression in the mouse blastocyst as a response to stress .
9811446	0	gadd34	52,58	gadd45	60,66	gadd34	gadd45	171071(Tax:10116)	25112(Tax:10116)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Myc suppresses induction of the growth_arrest genes gadd34 , gadd45 , and gadd153 by DNA-damaging agents .
8668205	0	gadd45	59,65	C/EBPalpha	0,10	gadd45	C/EBPalpha	1647	1050	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	C/EBPalpha regulation of the growth-arrest-associated gene gadd45 .
9190899	0	gadd45	37,43	Myc	0,3	gadd45	Myc	1647	4609	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Myc represses the growth_arrest gene gadd45 .
10514426	0	gadd45	0,6	c-Jun_N-terminal_kinase	41,64	gadd45	c-Jun N-terminal kinase	13197(Tax:10090)	26419(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	gadd45 is not required for activation of c-Jun_N-terminal_kinase or p38 during acute stress .
9811446	0	gadd45	60,66	gadd34	52,58	gadd45	gadd34	25112(Tax:10116)	171071(Tax:10116)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Myc suppresses induction of the growth_arrest genes gadd34 , gadd45 , and gadd153 by DNA-damaging agents .
10749144	0	gadd45	52,58	p53	36,39	gadd45	p53	1647	7157	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	A DNA damage signal is required for p53 to activate gadd45 .
15721278	0	gadd45alpha	35,46	NF-kappaB	14,23	gadd45alpha	NF-kappaB	13197(Tax:10090)	18033(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY stabilizes|dobj|mRNA stabilizes|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of NF-kappaB stabilizes gadd45alpha mRNA .
25205658	0	gadd45b2	61,69	Coiled-Coil_Domain_Containing_80	4,36	gadd45b2	Coiled-Coil Domain Containing 80	406304(Tax:7955)	368419(Tax:7955)	Gene	Gene	Expression|compound|START_ENTITY END_ENTITY|dep|Expression	The Coiled-Coil_Domain_Containing_80 -LRB- ccdc80 -RRB- Gene Regulates gadd45b2 Expression in the Developing Somites of Zebrafish as a New Player of the Hedgehog Pathway .
16232886	0	gadd_153	94,102	TNF-alpha	49,58	gadd 153	TNF-alpha	1649	7124	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|gene gene|amod|END_ENTITY	Bystander-killing effect and cyclic induction of TNF-alpha gene under heat-inducible promoter gadd_153 .
16233154	0	gadd_153	78,86	TNF-alpha	20,29	gadd 153	TNF-alpha	1649	7124	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Radiation-inducible TNF-alpha gene expression under stress-inducible promoter gadd_153 for cancer therapy .
10021361	0	gads	43,47	SLP-76	104,110	Grb2	SLP-76	2885	3937	Gene	Gene	START_ENTITY|dobj|functions functions|nmod|signaling signaling|nmod|interactions interactions|nmod|adaptors adaptors|compound|END_ENTITY	The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors .
16275648	0	gag	87,90	ABCE1	96,101	gag	ABCE1	155030(Tax:11676)	6059	Gene	Gene	interaction|nmod|START_ENTITY required|nmod|interaction required|nmod|END_ENTITY	Basic residues in the nucleocapsid domain of Gag are required for interaction of HIV-1 gag with ABCE1 -LRB- HP68 -RRB- , a cellular protein important for HIV-1 capsid assembly .
11861840	0	gag	81,84	CD8	19,22	gag	CD8	155030(Tax:11676)	925	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	High-level primary CD8 -LRB- + -RRB- T-cell response to human_immunodeficiency_virus_type_1 gag and env generated by vaccination with recombinant_vesicular_stomatitis viruses .
16652028	0	gag	70,73	CD8	38,41	gag	CD8	155030(Tax:11676)	925	Gene	Gene	protein|compound|START_ENTITY cross-stimulation|nmod|protein cross-stimulation|nmod|T-cells T-cells|compound|END_ENTITY	Dominant ex vivo cross-stimulation of CD8 + T-cells with whole soluble gag protein in HIV-infected subjects .
24227853	0	gag	56,59	CD8	123,126	gag	CD8	17276(Tax:10090)	925	Gene	Gene	antigen|compound|START_ENTITY introduces|dobj|antigen protein|acl:relcl|introduces Vaccination|nmod|protein construct|nsubj|Vaccination construct|dobj|results results|nmod|responses responses|compound|END_ENTITY	Vaccination with a fusion protein that introduces HIV-1 gag antigen into a multitrimer CD40L construct results in enhanced CD8 + T cell responses and protection from viral challenge by vaccinia-gag .
16734558	0	gag	26,29	GM-CSF	63,69	gag	GM-CSF	17276(Tax:10090)	1437	Gene	Gene	START_ENTITY|nmod|delivery delivery|nmod|END_ENTITY	Enhancing efficacy of HIV gag DNA vaccine by local delivery of GM-CSF in murine and macaque models .
23302874	0	gag	25,28	Gag-Pol	71,78	gag	Gag-Pol	155030(Tax:11676)	155348(Tax:11676)	Gene	Gene	START_ENTITY|acl|processing processing|nmod|dimerization dimerization|amod|END_ENTITY	Efavirenz enhances HIV-1 gag processing at the plasma membrane through Gag-Pol dimerization .
8668923	0	gag	68,71	P17	64,67	gag	P17	155030(Tax:11676)	653820	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Adjuvant properties of montanide_CSA 720 with a recombinant HIV P17 gag protein and synthetic peptide antigens .
9150887	0	gag	43,46	Rev	11,14	gag	Rev	155030(Tax:11676)	155908(Tax:11676)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression .
2064827	0	gag	23,26	p17	0,3	gag	p17	155030(Tax:11676)	653820	Gene	Gene	precursors|compound|START_ENTITY precursors|amod|END_ENTITY	p17 and p17-containing gag precursors of input human_immunodeficiency_virus are transported into the nuclei of infected cells .
6304352	0	gag	76,79	p19	65,68	gag	p19	1491923(Tax:11886)	51561	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Transformation-defective Rous_sarcoma_virus mutants with altered p19 of the gag gene and their inhibitory effect on host cell growth .
22829115	0	gag	18,21	p24	14,17	gag	p24	2760846(Tax:11901)	10959	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Expression of p24 gag protein of bovine_leukemia_virus in insect cells and its use in immunodetection of the disease .
23015721	0	gag	53,56	p24	49,52	gag	p24	155030(Tax:11676)	10959	Gene	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness .
2787798	0	gag	71,74	p24	84,87	gag	p24	1491934(Tax:11908)	10959	Gene	Gene	START_ENTITY|dobj|proteins proteins|nummod|END_ENTITY	Frequent lack of antibodies against human_T-cell_leukemia_virus_type_I gag proteins p24 or p19 in sera of patients with adult_T-cell_leukemia .
1376136	0	gag	92,95	p25	96,99	gag	p25	17276(Tax:10090)	15507(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	HIV-1 env , nef , and gag-specific T-cell immunity in mice : conserved epitopes in nef p27 and gag p25 proteins .
2960408	0	gag	42,45	p30	51,54	gag	p30	17276(Tax:10090)	15289(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Human autoimmune serum antibodies against gag gene p30 retroviral protein also react with a U1-SnRNP 68K comigrant protein .
26232767	0	galactinol_synthase	30,49	GolS	51,55	galactinol synthase	GolS	100316891(Tax:4081)	100316891(Tax:4081)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genome-wide identification of galactinol_synthase -LRB- GolS -RRB- genes in Solanum_lycopersicum and Brachypodium_distachyon .
26232767	0	galactinol_synthase	30,49	GolS	51,55	galactinol synthase	GolS	100316891(Tax:4081)	100316891(Tax:4081)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genome-wide identification of galactinol_synthase -LRB- GolS -RRB- genes in Solanum_lycopersicum and Brachypodium_distachyon .
7601472	0	galactocerebrosidase	40,60	GALC	62,66	galactocerebrosidase	GALC	2581	2581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and organization of the human galactocerebrosidase -LRB- GALC -RRB- gene .
9441867	0	galactocerebrosidase	48,68	GALC	70,74	galactocerebrosidase	GALC	2581	2581	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the 5 ' flanking region of the human galactocerebrosidase -LRB- GALC -RRB- gene .
6374427	0	galactokinase	14,27	GAL1	29,33	galactokinase	GAL1	852308(Tax:4932)	852308(Tax:4932)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of galactokinase -LRB- GAL1 -RRB- enzyme accumulation in Saccharomyces_cerevisiae .
8908517	0	galactokinase	28,41	GALK1	42,47	galactokinase	GALK1	2584	2584	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Fine structure of the human galactokinase GALK1 gene .
18957435	0	galactokinase	36,49	Gal1p	68,73	galactokinase	Gal1p	852308(Tax:4932)	852308(Tax:4932)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The effect of ligand binding on the galactokinase activity of yeast Gal1p and its ability to activate transcription .
8658143	0	galactokinase	58,71	Gal4p	14,19	galactokinase	Gal4p	852308(Tax:4932)	855828(Tax:4932)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p .
8826435	0	galactosamine-6-sulfate_sulfatase	40,73	GALNS	75,80	galactosamine-6-sulfate sulfatase	GALNS	2588	2588	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Heteroallelic missense mutations of the galactosamine-6-sulfate_sulfatase -LRB- GALNS -RRB- gene in a mild form of Morquio_disease -LRB- MPS_IVA -RRB- .
10408771	0	galactose-1-phosphate_uridyl_transferase	44,84	GALT	86,90	galactose-1-phosphate uridyl transferase	GALT	2592	2592	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Classical_galactosemia and mutations at the galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene .
12521227	0	galactose-1-phosphate_uridyl_transferase	80,120	GALT	122,126	galactose-1-phosphate uridyl transferase	GALT	2592	2592	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequencies of Q188R and N314D mutations and IVS5-24g > A intron variation in the galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene in the Slovenian population .
17079880	0	galactose-1-phosphate_uridyl_transferase	47,87	GALT	89,93	galactose-1-phosphate uridyl transferase	GALT	2592	2592	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of an unusual deletion of the galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene .
21188552	0	galactose-1-phosphate_uridyl_transferase	97,137	GALT	139,143	galactose-1-phosphate uridyl transferase	GALT	2592	2592	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A case of classical_galactosemia : identification and characterization of 3 distinct mutations in galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- gene in a single family .
10220154	0	galactose-1-phosphate_uridyltransferase	35,74	GALT	76,80	galactose-1-phosphate uridyltransferase	GALT	2592	2592	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of mutations in the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene in 16 Turkish patients with galactosemia , including a novel mutation of F294Y .
17486650	0	galactose-1-phosphate_uridyltransferase	26,65	GALT	67,71	galactose-1-phosphate uridyltransferase	GALT	2592	2592	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation database for the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene .
25592817	0	galactose-1-phosphate_uridyltransferase	171,210	GALT	212,216	galactose-1-phosphate uridyltransferase	GALT	2592	2592	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical and molecular spectra in galactosemic patients from neonatal screening in northeastern Italy : Structural and functional characterization of new variations in the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene .
26043515	0	galactose-1-phosphate_uridyltransferase	27,66	GALT	68,72	galactose-1-phosphate uridyltransferase	GALT	104914764	104914764	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the galactose-1-phosphate_uridyltransferase -LRB- GALT -RRB- gene in southeast part of Turkey : a regional report .
15211654	0	galactosyltransferase-I	33,56	B4GALT7	58,65	galactosyltransferase-I	B4GALT7	11285	11285	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel missense mutation in the galactosyltransferase-I -LRB- B4GALT7 -RRB- gene in a family exhibiting facioskeletal_anomalies and Ehlers-Danlos_syndrome resembling the progeroid type .
12487125	0	galanin	24,31	GALR1	18,23	galanin	GALR1	14419(Tax:10090)	14427(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity .
12487125	0	galanin	44,51	GALR1	18,23	galanin	GALR1	14419(Tax:10090)	14427(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY receptor|nmod|regulation receptor|compound|END_ENTITY	Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity .
9450684	0	galanin	47,54	GALR1	0,5	galanin	GALR1	29141(Tax:10116)	50577(Tax:10116)	Gene	Gene	neurons|compound|START_ENTITY co-expressed|nmod|neurons co-expressed|nsubjpass|mRNA mRNA|nummod|END_ENTITY	GALR1 galanin receptor mRNA is co-expressed by galanin neurons but not cholinergic neurons in the rat basal forebrain .
9450684	0	galanin	6,13	GALR1	0,5	galanin	GALR1	29141(Tax:10116)	50577(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nummod|END_ENTITY	GALR1 galanin receptor mRNA is co-expressed by galanin neurons but not cholinergic neurons in the rat basal forebrain .
15899880	0	galanin	52,59	GALR2	70,75	galanin	GALR2	14419(Tax:10090)	14428(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Phenotypic analysis of mice deficient_in_the_type_2 galanin receptor -LRB- GALR2 -RRB- .
15934937	0	galanin	55,62	GalR1	0,5	galanin	GalR1	14419(Tax:10090)	14427(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|ccomp|END_ENTITY	GalR1 , but not GalR2 or GalR3 , levels are regulated by galanin signaling in the locus coeruleus through a cyclic_AMP-dependent mechanism .
20121116	0	galanin	12,19	GalR1	56,61	galanin	GalR1	14419(Tax:10090)	14427(Tax:10090)	Gene	Gene	analogues|nsubj|START_ENTITY analogues|dobj|subtypes subtypes|amod|discriminate discriminate|nmod|END_ENTITY	Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery .
9271210	0	galanin	72,79	GalR1	66,71	galanin	GalR1	14419(Tax:10090)	14427(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Genomic organization and functional characterization of the mouse GalR1 galanin receptor .
9578554	0	galanin	60,67	GalR2	54,59	galanin	GalR2	100760816	100760610	Gene	Gene	subtypes|compound|START_ENTITY subtypes|compound|END_ENTITY	Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes .
9832122	0	galanin	16,23	GalR2	10,15	galanin	GalR2	14419(Tax:10090)	14428(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The mouse GalR2 galanin receptor : genomic organization , cDNA cloning , and functional characterization .
9067843	0	galanin	28,35	Nerve_growth_factor	0,19	galanin	Nerve growth factor	29141(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Nerve_growth_factor induces galanin gene expression in the rat basal_forebrain : implications for the treatment of cholinergic_dysfunction .
15582716	0	galanin	75,82	PDGF-B	93,99	galanin	PDGF-B	14419(Tax:10090)	18591(Tax:10090)	Gene	Gene	overexpressing|dobj|START_ENTITY overexpressing|nmod|promoter promoter|amod|END_ENTITY	Behavioural characterisation of young adult transgenic_mice overexpressing galanin under the PDGF-B promoter .
15944026	0	galanin	63,70	PDGF-B	81,87	galanin	PDGF-B	14419(Tax:10090)	18591(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Behavioural characterisation of transgenic_mice overexpressing galanin under the PDGF-B promoter .
12487125	0	galanin	24,31	galanin	44,51	galanin	galanin	14419(Tax:10090)	14419(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|regulation regulation|compound|END_ENTITY	Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity .
12487125	0	galanin	44,51	galanin	24,31	galanin	galanin	14419(Tax:10090)	14419(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY receptor|nmod|regulation receptor|compound|END_ENTITY	Critical role for GALR1 galanin receptor in galanin regulation of neuroendocrine function and seizure activity .
10690937	0	galanin	11,18	growth_hormone	22,36	galanin	growth hormone	51083	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of galanin on growth_hormone and prolactin secretion in anorexia_nervosa .
2477790	0	galanin	15,22	growth_hormone	26,40	galanin	growth hormone	51083	2688	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	The effects of galanin on growth_hormone secretion in children of normal and short_stature .
11358450	0	galanin	41,48	leukemia_inhibitory_factor	11,37	galanin	leukemia inhibitory factor	14419(Tax:10090)	16878(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of leukemia_inhibitory_factor on galanin expression and on axonal growth in adult dorsal root ganglion neurons in vitro .
7504265	0	galanin	91,98	luteinizing_hormone-releasing_hormone	102,139	galanin	luteinizing hormone-releasing hormone	29141(Tax:10116)	25194(Tax:10116)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Neonatal imprinting predetermines the sexually dimorphic , estrogen-dependent expression of galanin in luteinizing_hormone-releasing_hormone neurons .
8577925	0	galanin	11,18	proinsulin	22,32	galanin	proinsulin	14419(Tax:10090)	16334(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|compound|END_ENTITY	Effects of galanin on proinsulin mRNA and insulin biosynthesis in normal islets .
11459819	0	galanin-like_peptide	22,42	GALP	44,48	galanin-like peptide	GALP	64568(Tax:10116)	64568(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Stimulation effect of galanin-like_peptide -LRB- GALP -RRB- on luteinizing hormone-releasing hormone-mediated luteinizing hormone -LRB- LH -RRB- secretion in male rats .
11713207	0	galanin-like_peptide	31,51	GALP	53,57	galanin-like peptide	GALP	232836(Tax:10090)	232836(Tax:10090)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and regulation of galanin-like_peptide -LRB- GALP -RRB- in the hypothalamus of the mouse .
11755241	0	galanin-like_peptide	37,57	GALP	59,63	galanin-like peptide	GALP	64568(Tax:10116)	64568(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of a galanin-like_peptide -LRB- GALP -RRB- in pituicytes of the rat posterior pituitary gland .
16042964	0	galanin-like_peptide	11,31	GALP	33,37	galanin-like peptide	GALP	232836(Tax:10090)	232836(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of galanin-like_peptide -LRB- GALP -RRB- on locomotion , reproduction , and body weight in female and male mice .
11900829	0	galanin_receptor-1	14,32	GALR1	34,39	galanin receptor-1	GALR1	50577(Tax:10116)	50577(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of galanin_receptor-1 -LRB- GALR1 -RRB- in the rat trigeminal ganglia and molar teeth .
15748163	0	galanin_receptor-1	13,31	GalR1	33,38	galanin receptor-1	GalR1	14427(Tax:10090)	14427(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of galanin_receptor-1 -LRB- GalR1 -RRB- expression in external granule cell layer of post-natal mouse cerebellum .
12406501	0	galanin_receptor_3	27,45	GalR3	47,52	galanin receptor 3	GalR3	29235(Tax:10116)	29235(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Restricted distribution of galanin_receptor_3 -LRB- GalR3 -RRB- mRNA in the adult rat central nervous system .
18595677	0	galanin_receptors	36,53	GAL-R1	55,61	galanin receptors	GAL-R1	101123170	101123170	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Immunohistochemical localization of galanin_receptors -LRB- GAL-R1 , GAL-R2 , and GAL-R3 -RRB- on myenteric neurons from the sheep and dog stomach .
10642604	0	galectin-1	30,40	CD2	15,18	galectin-1	CD2	3956	914	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of CD2 and CD3 in galectin-1 induced signaling in human Jurkat T-cells .
23244209	0	galectin-1	14,24	Gal-1	26,31	galectin-1	Gal-1	3956	3956	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	A decrease in galectin-1 -LRB- Gal-1 -RRB- levels correlates with an increase in anti-Gal-1 antibodies at the synovial level in patients with rheumatoid_arthritis .
11522829	0	galectin-1	15,25	Gemin4	46,52	galectin-1	Gemin4	3956	50628	Gene	Gene	Association|acl|START_ENTITY Association|nmod|END_ENTITY	Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein .
15538736	0	galectin-1	8,18	IL-10	27,32	galectin-1	IL-10	3956	3586	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Dimeric galectin-1 induces IL-10 production in T-lymphocytes : an important tool in the regulation of the immune response .
16581128	0	galectin-1	48,58	IL-10	18,23	galectin-1	IL-10	3956	3586	Gene	Gene	homodimers|amod|START_ENTITY using|dobj|homodimers production|acl|using production|compound|END_ENTITY	Strongly enhanced IL-10 production using stable galectin-1 homodimers .
21191065	0	galectin-1	20,30	IL-10	97,102	galectin-1	IL-10	3956	3586	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Lung_cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor_of_DNA_binding_3 / IL-10 signaling pathway .
25292313	0	galectin-1	15,25	TBX21	78,83	galectin-1	TBX21	3956	30009	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of galectin-1 on the gene expression of the transcription factors TBX21 , GATA-3 , FOXP3 and RORC .
22392045	0	galectin-1	189,199	T_synthase	157,167	galectin-1	T synthase	16852(Tax:10090)	94192(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Knockdown of core 1 beta 1 , 3-galactosyltransferase prolongs skin allograft survival with induction of galectin-1 secretion and suppression of CD8 + T cells : T_synthase knockdown effects on galectin-1 and CD8 + T cells .
19032754	0	galectin-1	13,23	Tax	45,48	galectin-1	Tax	3956	1491938(Tax:11908)	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity .
11738361	0	galectin-1	115,125	desmin	27,33	galectin-1	desmin	3956	1674	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	The muscle-specific marker desmin is expressed in a proportion of human dermal fibroblasts after their exposure to galectin-1 .
16900348	0	galectin-1	14,24	transforming_growth_factor_beta1	39,71	galectin-1	transforming growth factor beta1	3956	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of galectin-1 expression by transforming_growth_factor_beta1 in metastatic mammary_adenocarcinoma cells : implications for tumor-immune escape .
19726041	0	galectin-2	47,57	lymphotoxin-alpha	28,45	galectin-2	lymphotoxin-alpha	3957	4049	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Lack of association between lymphotoxin-alpha , galectin-2 polymorphisms and coronary_artery_disease : a meta-analysis .
20144269	0	galectin-3	101,111	CD133	0,5	galectin-3	CD133	3958	8842	Gene	Gene	T|nmod|START_ENTITY T|nsubj|END_ENTITY	CD133 -LRB- + -RRB- human pulmonary_adenocarcinoma cells induce apoptosis of CD8 -LRB- + -RRB- T cells by highly expressed galectin-3 .
17592963	0	galectin-3	30,40	HIF-1_alpha	0,11	galectin-3	HIF-1 alpha	16854(Tax:10090)	15251(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	HIF-1_alpha is a regulator of galectin-3 expression in the intervertebral disc .
24755837	0	galectin-3	28,38	LGALS3	20,26	galectin-3	LGALS3	3958	3958	Gene	Gene	Characterization|dep|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of LGALS3 -LRB- galectin-3 -RRB- as a player in DNA damage response .
17420249	0	galectin-3	15,25	tumor_necrosis_factor-related_apoptosis-inducing_ligand	35,90	galectin-3	tumor necrosis factor-related apoptosis-inducing ligand	3958	8743	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Phosphorylated galectin-3 mediates tumor_necrosis_factor-related_apoptosis-inducing_ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast_carcinoma cells .
25955862	0	galectin-8	21,31	RANKL	40,45	galectin-8	RANKL	3964	8600	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The mammalian lectin galectin-8 induces RANKL expression , osteoclastogenesis , and bone mass reduction in mice .
11726788	0	galectin-9	29,39	Interleukin-1beta	0,17	galectin-9	Interleukin-1beta	3965	3553	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-1beta stimulates galectin-9 expression in human astrocytes .
23555261	0	galectin-9	37,47	TIM-3	0,5	galectin-9	TIM-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY act|nmod|receptor act|nsubj|END_ENTITY	TIM-3 does not act as a receptor for galectin-9 .
24651720	0	galectin-9	80,90	TIM-3	17,22	galectin-9	TIM-3	3965	84868	Gene	Gene	interaction|amod|START_ENTITY TIM-3|dep|interaction NK|dep|TIM-3 NK|compound|END_ENTITY	Peripheral blood TIM-3 positive NK and CD8 + T cells throughout pregnancy : TIM-3 / galectin-9 interaction and its possible role during pregnancy .
24651720	0	galectin-9	80,90	TIM-3	74,79	galectin-9	TIM-3	3965	84868	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Peripheral blood TIM-3 positive NK and CD8 + T cells throughout pregnancy : TIM-3 / galectin-9 interaction and its possible role during pregnancy .
25784621	0	galectin-9	82,92	TIM-3	59,64	galectin-9	TIM-3	3965	84868	Gene	Gene	START_ENTITY|nsubj|Participation_of_T_cell_immunoglobulin_and_mucin_domain-3 Participation_of_T_cell_immunoglobulin_and_mucin_domain-3|appos|END_ENTITY	Participation_of_T_cell_immunoglobulin_and_mucin_domain-3 -LRB- TIM-3 -RRB- and its ligand -LRB- galectin-9 -RRB- in the pathogenesis of active_generalized_vitiligo .
26278059	0	galectin-9	41,51	TIM-3	35,40	galectin-9	TIM-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY regulation|dep|pathway regulation|nmod|END_ENTITY	Feto-maternal immune regulation by TIM-3 / galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy .
26278059	0	galectin-9	41,51	TIM-3	35,40	galectin-9	TIM-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY regulation|dep|pathway regulation|nmod|END_ENTITY	Feto-maternal immune regulation by TIM-3 / galectin-9 pathway and PD-1 molecule in mice at day 14.5 of pregnancy .
26239720	0	galectin-9	87,97	T_cell_immunoglobulin_and_mucin_protein_3	45,86	galectin-9	T cell immunoglobulin and mucin protein 3	3965	84868	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of immune checkpoint molecules of T_cell_immunoglobulin_and_mucin_protein_3 / galectin-9 for NK cell suppression in human gastrointestinal_stromal_tumors .
16286920	0	galectin-9	17,27	Tim-3	4,9	galectin-9	Tim-3	3965	84868	Gene	Gene	ligand|xcomp|START_ENTITY ligand|nsubj|END_ENTITY	The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity .
17069754	0	galectin-9	86,96	Tim-3	31,36	galectin-9	Tim-3	3965	84868	Gene	Gene	phosphorylated|nmod|START_ENTITY phosphorylated|nsubjpass|tyrosine tyrosine|nmod|END_ENTITY	A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9 .
19100864	0	galectin-9	31,41	Tim-3	17,22	galectin-9	Tim-3	3965	84868	Gene	Gene	Detection|amod|START_ENTITY Detection|nmod|END_ENTITY	Detection of the Tim-3 ligand , galectin-9 , inside the allograft during a rejection episode .
19234217	0	galectin-9	14,24	Tim-3	8,13	galectin-9	Tim-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY /|dobj|interaction /|nsubj|Role Role|nmod|END_ENTITY	Role of Tim-3 / galectin-9 inhibitory interaction in viral-induced immunopathology : shifting the balance toward regulators .
20574007	0	galectin-9	6,16	Tim-3	0,5	galectin-9	Tim-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|dep|pathway	Tim-3 / galectin-9 pathway : regulation of Th1 immunity through promotion of CD11b + Ly-6G + myeloid cells .
22323453	0	galectin-9	114,124	Tim-3	0,5	galectin-9	Tim-3	3965	84868	Gene	Gene	enhances|nmod|START_ENTITY receptor|acl:relcl|enhances receptor|nsubj|END_ENTITY	Tim-3 is an inducible human natural killer cell receptor that enhances interferon_gamma production in response to galectin-9 .
22505239	0	galectin-9	6,16	Tim-3	0,5	galectin-9	Tim-3	3965	84868	Gene	Gene	signaling|amod|START_ENTITY mediates|nsubj|signaling END_ENTITY|parataxis|mediates	Tim-3 / galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis_B_virus-associated hepatocellular_carcinoma .
22677125	0	galectin-9	61,71	Tim-3	55,60	galectin-9	Tim-3	3965	84868	Gene	Gene	blockade|amod|START_ENTITY blockade|dep|Contrasting Contrasting|dobj|effects effects|nmod|END_ENTITY	Contrasting acute graft-versus-host disease effects of Tim-3 / galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells .
23112829	0	galectin-9	26,36	Tim-3	20,25	galectin-9	Tim-3	3965	84868	Gene	Gene	pathway|amod|START_ENTITY Upregulation|dep|pathway Upregulation|nmod|END_ENTITY	Upregulation of the Tim-3 / galectin-9 pathway of T cell exhaustion in chronic hepatitis_B_virus infection .
24333756	0	galectin-9	10,20	Tim-3	4,9	galectin-9	Tim-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY involves|nsubj|pathway END_ENTITY|parataxis|involves	The Tim-3 / galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis .
24639110	0	galectin-9	18,28	Tim-3	12,17	galectin-9	Tim-3	3965	84868	Gene	Gene	stem|nsubj|START_ENTITY Hypothesis|parataxis|stem Hypothesis|dep|END_ENTITY	Hypothesis : Tim-3 / galectin-9 , a new pathway for leukemia stem cells survival by promoting expansion of myeloid-derived suppressor cells and differentiating into tumor-associated macrophages .
25264706	0	galectin-9	82,92	Tim-3	41,46	galectin-9	Tim-3	16859(Tax:10090)	363578(Tax:10116)	Gene	Gene	system|amod|START_ENTITY Regulation|dep|system Regulation|nmod|osteoclastogenesis osteoclastogenesis|nmod|END_ENTITY	Regulation of osteoclastogenesis through Tim-3 : possible involvement of the Tim-3 / galectin-9 system in the modulation of inflammatory bone_destruction .
25264706	0	galectin-9	82,92	Tim-3	76,81	galectin-9	Tim-3	16859(Tax:10090)	363578(Tax:10116)	Gene	Gene	system|amod|START_ENTITY Regulation|dep|system Regulation|dep|involvement involvement|nmod|END_ENTITY	Regulation of osteoclastogenesis through Tim-3 : possible involvement of the Tim-3 / galectin-9 system in the modulation of inflammatory bone_destruction .
26494364	0	galectin-9	18,28	Tim-3	12,17	galectin-9	Tim-3	16859(Tax:10090)	171285(Tax:10090)	Gene	Gene	expressions|amod|START_ENTITY END_ENTITY|dep|expressions	Upregulated Tim-3 / galectin-9 expressions in acute_lung_injury in a murine malarial model .
22323453	0	galectin-9	114,124	interferon_gamma	71,87	galectin-9	interferon gamma	3965	3458	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|production production|compound|END_ENTITY	Tim-3 is an inducible human natural killer cell receptor that enhances interferon_gamma production in response to galectin-9 .
22371007	0	galectin-9	80,90	tim-3	91,96	galectin-9	tim-3	3965	84868	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	The impaired immune regulation of autoimmune_hepatitis is linked to a defective galectin-9 / tim-3 pathway .
16227255	0	galectin_9	74,84	LMP1	54,58	galectin 9	LMP1	3965	9260	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	In nasopharyngeal_carcinoma cells , Epstein-Barr_virus LMP1 interacts with galectin_9 in membrane raft elements resistant to simvastatin .
19208545	0	gametogenetin-binding_protein_1	27,58	GGNBP1	60,66	gametogenetin-binding protein 1	GGNBP1	70772(Tax:10090)	70772(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel potential role for gametogenetin-binding_protein_1 -LRB- GGNBP1 -RRB- in mitochondrial morphogenesis during spermatogenesis in mice .
27090238	0	gamma-1_adaptin	30,45	Ap1g1	52,57	gamma-1 adaptin	Ap1g1	11765(Tax:10090)	11765(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A hypomorphic mutation of the gamma-1_adaptin gene -LRB- Ap1g1 -RRB- causes inner ear , retina , thyroid , and testes_abnormalities in mice .
22737924	0	gamma-GCS	58,67	KLF2	36,40	gamma-GCS	KLF2	25283(Tax:10116)	306330(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The effect of transcription factor KLF2 in expression of gamma-GCS depend on regulation by Nrf2 in lung of rats with chronic_obstructive_pulmonary_disease -RSB- .
12198383	0	gamma-GTP	92,101	gamma-glutamyl_transpeptidase	61,90	gamma-GTP	gamma-glutamyl transpeptidase	92086	92086	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Significant correlation between insulin resistance and serum gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- activity in non-drinkers .
2891274	0	gamma-GTP	111,120	gamma-glutamyl_transpeptidase	80,109	gamma-GTP	gamma-glutamyl transpeptidase	92086	92086	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- activity in human semen : its relation to gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- activity in seminal plasma and reproductive tissues , and relation between seminal mucoprotein concentration and seminal NAG , and gamma-GTP activities -RSB- .
2464917	0	gamma-Sm	191,199	gamma-seminoprotein	170,189	gamma-Sm	gamma-seminoprotein	354	354	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Clinical study of tumor markers in prostatic_carcinoma -- an investigation on the simultaneous measurement of prostatic acid phosphatase -LRB- PAP -RRB- , prostatic antigen -LRB- PA -RRB- and gamma-seminoprotein -LRB- gamma-Sm -RRB- -RSB- .
9653655	0	gamma-adaptin	78,91	ADTG	98,102	gamma-adaptin	ADTG	164	164	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning , expression pattern , and chromosomal assignment to 16q23 of the human gamma-adaptin gene -LRB- ADTG -RRB- .
12498786	0	gamma-adaptin	59,72	synaptophysin	15,28	gamma-adaptin	synaptophysin	164	6855	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin .
861203	0	gamma-butyrobetaine_hydroxylase	31,62	AK_1	83,87	gamma-butyrobetaine hydroxylase	AK 1	8424	203	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and properties of gamma-butyrobetaine_hydroxylase from Pseudomonas sp AK_1 .
11038172	1	gamma-filamin	52,65	myotilin	119,127	gamma-filamin	myotilin	2318	9499	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	gamma-filamin , the muscle-specific filamin isoform , interacts with myotilin .
17786385	0	gamma-glutamyl_carboxylase	52,78	GGCX	85,89	gamma-glutamyl carboxylase	GGCX	2677	2677	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High-resolution SNP and haplotype maps of the human gamma-glutamyl_carboxylase gene -LRB- GGCX -RRB- and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population .
21797800	0	gamma-glutamyl_transferase	6,32	GGT	34,37	gamma-glutamyl transferase	GGT	2678	2678	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum gamma-glutamyl_transferase -LRB- GGT -RRB- levels and inflammatory activity in patients with non-dipper hypertension .
10572675	0	gamma-glutamyl_transpeptidase	44,73	GGT	75,78	gamma-glutamyl transpeptidase	GGT	92086	92086	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	-LSB- Relationship between methylation status of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- genes and abnormal expression of its enzyme proteins in tissues of human hepatomas -RSB- .
15893589	0	gamma-glutamyl_transpeptidase	17,46	GGT	48,51	gamma-glutamyl transpeptidase	GGT	92086	92086	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Up-regulation of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- activity in growth perturbed C6 astrocytes .
1970549	0	gamma-glutamyl_transpeptidase	19,48	GGT	50,53	gamma-glutamyl transpeptidase	GGT	92086	92086	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of human gamma-glutamyl_transpeptidase -LRB- GGT -RRB- during the fetal development of liver .
7854499	0	gamma-glutamyl_transpeptidase	43,72	GGT	74,77	gamma-glutamyl transpeptidase	GGT	14598(Tax:10090)	14598(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Enhanced erythropoietin and suppression of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- activity in murine lymphoma following administration of vanadium .
7854499	0	gamma-glutamyl_transpeptidase	43,72	erythropoietin	9,23	gamma-glutamyl transpeptidase	erythropoietin	14598(Tax:10090)	13856(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Enhanced erythropoietin and suppression of gamma-glutamyl_transpeptidase -LRB- GGT -RRB- activity in murine lymphoma following administration of vanadium .
12198383	0	gamma-glutamyl_transpeptidase	61,90	gamma-GTP	92,101	gamma-glutamyl transpeptidase	gamma-GTP	92086	92086	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Significant correlation between insulin resistance and serum gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- activity in non-drinkers .
2891274	0	gamma-glutamyl_transpeptidase	80,109	gamma-GTP	111,120	gamma-glutamyl transpeptidase	gamma-GTP	92086	92086	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- N-acetyl-beta-D-glucosaminidase -LRB- NAG -RRB- activity in human semen : its relation to gamma-glutamyl_transpeptidase -LRB- gamma-GTP -RRB- activity in seminal plasma and reproductive tissues , and relation between seminal mucoprotein concentration and seminal NAG , and gamma-GTP activities -RSB- .
16434459	0	gamma-glutamyl_transpeptidase	6,35	insulin	56,63	gamma-glutamyl transpeptidase	insulin	92086	3630	Gene	Gene	determinant|nsubj|START_ENTITY determinant|nmod|resistance resistance|compound|END_ENTITY	Serum gamma-glutamyl_transpeptidase is a determinant of insulin resistance independently of adiposity in Pima Indian children .
21141598	0	gamma-glutamylcysteine_synthetase	26,59	NRF2	10,14	gamma-glutamylcysteine synthetase	NRF2	25283(Tax:10116)	83619(Tax:10116)	Gene	Gene	regulating|advmod|START_ENTITY Roles|acl|regulating Roles|nmod|END_ENTITY	-LSB- Roles of NRF2 regulating gamma-glutamylcysteine_synthetase in lung of rats with chronic_obstructive_pulmonary_disease -RSB- .
10559251	0	gamma-glutamylcysteine_synthetase	14,47	Nrf2	100,104	gamma-glutamylcysteine synthetase	Nrf2	2729	4780	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of gamma-glutamylcysteine_synthetase subunit gene expression by the transcription factor Nrf2 .
10751553	0	gamma-glutamylcysteine_synthetase	101,134	Nrf2	0,4	gamma-glutamylcysteine synthetase	Nrf2	2729	4780	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene regulation|dep|expression regulation|amod|END_ENTITY	Nrf2 and c-Jun regulation of antioxidant response element -LRB- ARE -RRB- - mediated expression and induction of gamma-glutamylcysteine_synthetase heavy subunit gene .
10544272	0	gamma-glutamylcysteine_synthetase	95,128	hepatocyte_growth_factor	53,77	gamma-glutamylcysteine synthetase	hepatocyte growth factor	25283(Tax:10116)	24446(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Elevation of glutathione level in rat hepatocytes by hepatocyte_growth_factor via induction of gamma-glutamylcysteine_synthetase .
18844495	0	gamma-glutamyltransferase	21,46	C-reactive_protein	52,70	gamma-glutamyltransferase	C-reactive protein	728226	1401	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Association of serum gamma-glutamyltransferase with C-reactive_protein levels and white blood cell count in Korean adults .
20484958	0	gamma-glutamyltransferase_1	55,82	GGT1	84,88	gamma-glutamyltransferase 1	GGT1	2678	2678	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pooling-based genome-wide association study implicates gamma-glutamyltransferase_1 -LRB- GGT1 -RRB- gene in pancreatic carcinogenesis .
1679348	0	gamma-glutamyltranspeptidase	11,39	GGT	41,44	gamma-glutamyltranspeptidase	GGT	116568(Tax:10116)	116568(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Peripartal gamma-glutamyltranspeptidase -LRB- GGT -RRB- activity in the mammary glands of pregnant Uje : WIST rats .
1687660	0	gamma-glutamyltranspeptidase	165,193	GGT	195,198	gamma-glutamyltranspeptidase	GGT	116568(Tax:10116)	116568(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- The effect of hadacidin , ultraviolet irradiation of blood -LRB- UVB -RRB- and thiamine on the prenatal development of Uje : WIST rats : correlation with the hepatic activity of gamma-glutamyltranspeptidase -LRB- GGT -RRB- -RSB- .
6119767	0	gamma-glutamyltranspeptidase	87,115	biliary_glycoprotein_I	15,37	gamma-glutamyltranspeptidase	biliary glycoprotein I	92086	634	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	Serum level of biliary_glycoprotein_I , a determinant of cholestasis , of similar use as gamma-glutamyltranspeptidase .
6408175	0	gamma-interferon	22,38	Interleukin_2	0,13	gamma-interferon	Interleukin 2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin_2 induces gamma-interferon production : participation of macrophages and NK-like cells .
6180065	0	gamma-interferon	72,88	MLC	118,121	gamma-interferon	MLC	15978(Tax:10090)	170790(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Characteristics of alloantigens and cellular mechanisms responsible for gamma-interferon production in primary murine MLC .
7850804	0	gamma-interferon	42,58	interleukin_2	191,204	gamma-interferon	interleukin 2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY increases|nsubj|mice increases|nmod|immunotherapy immunotherapy|amod|END_ENTITY	Treating_tumor-bearing mice with low-dose gamma-interferon plus tumor_necrosis_factor_alpha to diminish immune suppressive granulocyte-macrophage progenitor cells increases responsiveness to interleukin_2 immunotherapy .
15169664	0	gamma-seminoprotein	76,95	Fab	58,61	gamma-seminoprotein	Fab	354	2187	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Prokaryotic expression and bioactivity identification of Fab against human gamma-seminoprotein -RSB- .
2464917	0	gamma-seminoprotein	170,189	gamma-Sm	191,199	gamma-seminoprotein	gamma-Sm	354	354	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Clinical study of tumor markers in prostatic_carcinoma -- an investigation on the simultaneous measurement of prostatic acid phosphatase -LRB- PAP -RRB- , prostatic antigen -LRB- PA -RRB- and gamma-seminoprotein -LRB- gamma-Sm -RRB- -RSB- .
3517880	0	gamma-trace	101,112	cystatin_C	128,138	gamma-trace	cystatin C	1471	1471	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	Amyloid fibrils in hereditary_cerebral_hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein -LRB- cystatin_C -RRB- .
10372560	0	gamma2	116,122	LAMC2	135,140	gamma2	LAMC2	14406(Tax:10090)	16782(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Laminin-5 promotes adhesion and migration of epithelial cells : identification of a migration-related element in the gamma2 chain gene -LRB- LAMC2 -RRB- with activity in transgenic_mice .
10995575	0	gamma2-COP	16,26	COPG2	28,33	gamma2-COP	COPG2	26958	26958	Gene	Gene	gene|appos|START_ENTITY gene|appos|END_ENTITY	The novel gene , gamma2-COP -LRB- COPG2 -RRB- , in the 7q32 imprinted domain escapes genomic imprinting .
11352924	0	gamma_1-syntrophin	15,33	diacylglycerol_kinase-zeta	39,65	gamma 1-syntrophin	diacylglycerol kinase-zeta	54212	8525	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of gamma_1-syntrophin with diacylglycerol_kinase-zeta .
17078891	0	gamma_c	65,72	Rag2	58,62	gamma c	Rag2	16186(Tax:10090)	19374(Tax:10090)	Gene	Gene	/|parataxis|START_ENTITY END_ENTITY|dep|/	HIV-1_infection and CD4 T cell depletion in the humanized Rag2 - / - gamma_c - / - -LRB- RAG-hu -RRB- mouse model .
19011158	0	gamma_chain	14,25	CD127	70,75	gamma chain	CD127	3561	3575	Gene	Gene	cytokines|compound|START_ENTITY regulate|nsubj|cytokines regulate|dobj|+ +|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
19011158	0	gamma_chain	14,25	CD8	66,69	gamma chain	CD8	3561	925	Gene	Gene	cytokines|compound|START_ENTITY regulate|nsubj|cytokines regulate|dobj|+ +|compound|END_ENTITY	IL-2 receptor gamma_chain cytokines differentially regulate human CD8 + CD127 + and CD8 + CD127 - T cell division and susceptibility to apoptosis .
3095481	0	gamma_interferon	10,26	cachectin	30,39	gamma interferon	cachectin	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of gamma_interferon on cachectin expression by mononuclear phagocytes .
21039465	0	gamma_interferon-inducible_lysosomal_thiol_reductase	85,137	Signal_transducer_and_activator_of_transcription_1	0,50	gamma interferon-inducible lysosomal thiol reductase	Signal transducer and activator of transcription 1	10437	6772	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Signal_transducer_and_activator_of_transcription_1 negatively regulates constitutive gamma_interferon-inducible_lysosomal_thiol_reductase expression .
12566285	0	ganglioside-induced_differentiation-associated_protein-1	17,73	GDAP1	75,80	ganglioside-induced differentiation-associated protein-1	GDAP1	54332	54332	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the ganglioside-induced_differentiation-associated_protein-1 -LRB- GDAP1 -RRB- gene in intermediate type autosomal recessive Charcot-Marie-Tooth_neuropathy .
12525503	0	gankyrin	45,53	MAGE-A4	0,7	gankyrin	MAGE-A4	5716	4103	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity .
17904523	0	gankyrin	16,24	RelA	40,44	gankyrin	RelA	5716	5970	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity .
16177571	0	gankyrin	16,24	p53	51,54	gankyrin	p53	5716	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation .
23592915	0	gap_junction_alpha_3	49,69	connexin_46	36,47	gap junction alpha 3	connexin 46	2700	2700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A novel insertional mutation in the connexin_46 -LRB- gap_junction_alpha_3 -RRB- gene associated with autosomal dominant congenital_cataract in a Chinese family .
24503448	0	gap_junction_beta_2	68,87	GJB2	89,93	gap junction beta 2	GJB2	2706	2706	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hearing_loss associated with an unusual mutation combination in the gap_junction_beta_2 -LRB- GJB2 -RRB- gene in a Chinese family .
17601931	0	gap_junction_protein_alpha_8	16,44	GJA8	46,50	gap junction protein alpha 8	GJA8	2703	2703	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation of the gap_junction_protein_alpha_8 -LRB- GJA8 -RRB- gene causes autosomal recessive cataract .
21720542	0	gap_junction_protein_alpha_8	16,44	GJA8	46,50	gap junction protein alpha 8	GJA8	2703	2703	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation of the gap_junction_protein_alpha_8 -LRB- GJA8 -RRB- gene causes autosomal recessive cataract .
8220312	0	gas-1	64,69	growth_arrest_specific_gene	35,62	gas-1	growth arrest specific gene	683470(Tax:10116)	683470(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Estrogen-regulated expression of a growth_arrest_specific_gene -LRB- gas-1 -RRB- in rat uterus .
10733530	0	gas3	77,81	PMP-22	70,76	gas3	PMP-22	5376	5376	Gene	Gene	family|amod|START_ENTITY family|compound|END_ENTITY	PERP , an apoptosis-associated target of p53 , is a novel member of the PMP-22 / gas3 family .
1630459	0	gas5	60,64	growth_arrest-specific_gene	31,58	gas5	growth arrest-specific gene	14455(Tax:10090)	14455(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation and expression of a growth_arrest-specific_gene -LRB- gas5 -RRB- during growth , differentiation , and development .
9326369	0	gas6	17,21	Axl	86,89	gas6	Axl	2621	558	Gene	Gene	variant|amod|START_ENTITY product|nmod|variant allows|nsubj|product allows|dobj|release release|nmod|activation activation|amod|responsible responsible|nmod|kinase kinase|compound|END_ENTITY	The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation .
11411309	0	gas6	33,37	growth_arrest_specific_gene	4,31	gas6	growth arrest specific gene	101822418	101822418	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	The growth_arrest_specific_gene -LRB- gas6 -RRB- protein is expressed in abnormal embryos sired by male golden_hamsters with accessory sex glands removed .
7002390	0	gastric-inhibitory-peptide	27,53	GIP	55,58	gastric-inhibitory-peptide	GIP	2695	2695	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Autoantibodies to duodenal gastric-inhibitory-peptide -LRB- GIP -RRB- cells and to secretin -LRB- S -RRB- cells in patients with coeliac_disease , tropical_sprue and maturity-onset diabetes .
2869695	0	gastric_inhibitory_peptide	33,59	gastrin	14,21	gastric inhibitory peptide	gastrin	25040(Tax:10116)	25320(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Inhibition of gastrin release by gastric_inhibitory_peptide mediated by somatostatin .
6759077	0	gastric_inhibitory_polypeptide	12,42	insulin	60,67	gastric inhibitory polypeptide	insulin	2695	3630	Gene	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	The role of gastric_inhibitory_polypeptide in the augmented insulin response to sucrose .
10358049	0	gastric_lipase	27,41	lysosomal_acid_lipase	55,76	gastric lipase	lysosomal acid lipase	8513	3988	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human gastric_lipase and model of lysosomal_acid_lipase , two lipolytic enzymes of medical interest .
16442704	0	gastrin	17,24	Akt	93,96	gastrin	Akt	2520	207	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|apoptosis apoptosis|nmod|cells cells|nmod|activation activation|nmod|pathways pathways|compound|END_ENTITY	Glycine-extended gastrin inhibits apoptosis in colon_cancer cells via separate activation of Akt and JNK pathways .
15613302	0	gastrin	47,54	BMRF1	31,36	gastrin	BMRF1	2520	17494230	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	The Epstein-Barr_virus protein BMRF1 activates gastrin transcription .
7457732	0	gastrin	46,53	Bombesin	0,8	gastrin	Bombesin	2520	2922	Gene	Gene	release|compound|START_ENTITY stimulator|nmod|release END_ENTITY|dep|stimulator	Bombesin : a vagally independent stimulator of gastrin release .
15682471	0	gastrin	45,52	CCK-A	12,17	gastrin	CCK-A	2520	886	Gene	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of CCK-A , B receptors and effect of gastrin and cholecystokinin on growth of pancreatobiliary_cancer cell lines .
15074389	0	gastrin	25,32	Cholecystokinin	0,15	gastrin	Cholecystokinin	445524(Tax:9823)	397468(Tax:9823)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Cholecystokinin inhibits gastrin secretion independently of paracrine somatostatin secretion in the pig .
2206341	0	gastrin	47,54	GIP	91,94	gastrin	GIP	280800(Tax:9913)	511073(Tax:9913)	Gene	Gene	polypeptide|compound|START_ENTITY polypeptide|appos|END_ENTITY	-LSB- Effect of hypoxia on plasma concentrations of gastrin and gastric inhibitory polypeptide -LRB- GIP -RRB- in newborn calves -RSB- .
6293900	0	gastrin	10,17	GIP	53,56	gastrin	GIP	2520	2695	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of gastrin on fasting and postprandial plasma GIP release in man .
938120	0	gastrin	15,22	GIP	88,91	gastrin	GIP	100685087	609020(Tax:9615)	Gene	Gene	release|compound|START_ENTITY Suppression|nmod|release secretion|nsubj|Suppression secretion|nmod|polypeptide polypeptide|appos|END_ENTITY	Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide -LRB- GIP -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- .
955338	0	gastrin	38,45	GIP	32,35	gastrin	GIP	2520	2695	Gene	Gene	polypeptide|appos|START_ENTITY polypeptide|appos|END_ENTITY	Gastric inhibitory polypeptide -LRB- GIP -RRB- , gastrin and insulin : response to test meal in coeliac_disease and after duodeno-pancreatectomy .
3518119	0	gastrin	44,51	Gastrin	1,8	gastrin	Gastrin	2520	2520	Gene	Gene	START_ENTITY|nsubj|cells cells|compound|END_ENTITY	-LSB- Gastrin cells and the basal level of serum gastrin in patients with insulin-dependent_diabetes_mellitus -RSB- .
8843754	0	gastrin	27,34	Growth_hormone	0,14	gastrin	Growth hormone	14459(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Growth_hormone upregulates gastrin and peptide_YY gene expression .
3092193	0	gastrin	59,66	Growth_hormone_releasing_hormone	0,32	gastrin	Growth hormone releasing hormone	25320(Tax:10116)	29446(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Growth_hormone_releasing_hormone stimulates the release of gastrin in rat .
2015894	0	gastrin	70,77	Histidine_decarboxylase	0,23	gastrin	Histidine decarboxylase	25320(Tax:10116)	24443(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Histidine_decarboxylase gene expression in rat fundus is regulated by gastrin .
14764072	0	gastrin	55,62	K-ras	0,5	gastrin	K-ras	2520	3845	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	K-ras and B-raf gene mutations are not associated with gastrin - and CCK2-receptor mRNA expression in human colorectal_tumour tissues .
17135306	0	gastrin	46,53	MEN1	24,28	gastrin	MEN1	2520	4221	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions .
24086717	0	gastrin	22,29	NR4A2	0,5	gastrin	NR4A2	2520	4929	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	NR4A2 is regulated by gastrin and influences cellular responses of gastric_adenocarcinoma cells .
25384047	0	gastrin	45,52	Salt-inducible_kinase_1	0,23	gastrin	Salt-inducible kinase 1	2520	150094	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Salt-inducible_kinase_1 -LRB- SIK1 -RRB- is induced by gastrin and inhibits migration of gastric_adenocarcinoma cells .
1098482	0	gastrin	19,26	Secretin	0,8	gastrin	Secretin	100685087	483407(Tax:9615)	Gene	Gene	effect|nmod|START_ENTITY effect|compound|END_ENTITY	Secretin effect on gastrin , gastric secretion in dogs with chronic antral stimulation .
21445336	0	gastrin	41,48	Smad_7	13,19	gastrin	Smad 7	2520	4092	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL1B induced Smad_7 negatively regulates gastrin expression .
1350357	0	gastrin	27,34	Somatostatin	0,12	gastrin	Somatostatin	100685087	403993(Tax:9615)	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression inhibition|compound|END_ENTITY	Somatostatin inhibition of gastrin gene expression : involvement of pertussis toxin-sensitive and - insensitive pathways .
1354190	0	gastrin	66,73	Somatostatin	0,12	gastrin	Somatostatin	445524(Tax:9823)	494469(Tax:9823)	Gene	Gene	secretion|compound|START_ENTITY inhibition|nmod|secretion link|nmod|inhibition link|nsubj|END_ENTITY	Somatostatin is an essential paracrine link in acid inhibition of gastrin secretion .
15935492	0	gastrin	46,53	Somatostatin	0,12	gastrin	Somatostatin	2520	6750	Gene	Gene	secretion|amod|START_ENTITY inhibit|dobj|secretion inhibit|nsubj|END_ENTITY	Somatostatin , misoprostol and galanin inhibit gastrin - and PACAP-stimulated secretion of histamine and pancreastatin from ECL cells by blocking specific Ca2 + channels .
1968059	0	gastrin	24,31	Somatostatin	0,12	gastrin	Somatostatin	100685087	403993(Tax:9615)	Gene	Gene	turnover|compound|START_ENTITY stimulates|dobj|turnover stimulates|nsubj|END_ENTITY	Somatostatin stimulates gastrin mRNA turnover in dog antral mucosa .
1974217	0	gastrin	64,71	Somatostatin	0,12	gastrin	Somatostatin	25320(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY increases|dobj|secretion increases|nsubj|immunoneutralization immunoneutralization|nummod|END_ENTITY	Somatostatin monoclonal antibody immunoneutralization increases gastrin and gastric_acid secretion in urethane-anesthetized rats .
6116596	0	gastrin	60,67	Somatostatin	0,12	gastrin	Somatostatin	100714563	100730851	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Somatostatin is an agonist and noncompetitive antagonist of gastrin in oxyntic cell function .
9227485	0	gastrin	22,29	Somatostatin	0,12	gastrin	Somatostatin	100685087	403993(Tax:9615)	Gene	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Somatostatin inhibits gastrin release and acid secretion by activating sst2 in dogs .
938120	0	gastrin	15,22	VIP	132,135	gastrin	VIP	100685087	484038(Tax:9615)	Gene	Gene	release|compound|START_ENTITY Suppression|nmod|release secretion|nsubj|Suppression secretion|nmod|polypeptide polypeptide|appos|END_ENTITY	Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide -LRB- GIP -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- .
12479069	0	gastrin	20,27	bcl-2	59,64	gastrin	bcl-2	2520	596	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	-LSB- Effect of external gastrin on apoptosis and expression of bcl-2 gene in gastric_cancer cells -RSB- .
15655830	0	gastrin	34,41	bcl-2	91,96	gastrin	bcl-2	2520	596	Gene	Gene	/|compound|START_ENTITY /|amod|END_ENTITY	Correlation between expression of gastrin , somatostatin and cell apoptosis regulation gene bcl-2 / bax in large intestine carcinoma .
1190200	0	gastrin	35,42	bombesin	10,18	gastrin	bombesin	2520	2922	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of bombesin on extragastric gastrin in man .
1972573	0	gastrin	56,63	bombesin	20,28	gastrin	bombesin	2520	2922	Gene	Gene	cells|compound|START_ENTITY Characterization|nmod|cells Characterization|nmod|receptors receptors|compound|END_ENTITY	Characterization of bombesin receptors on canine antral gastrin cells .
2092327	0	gastrin	34,41	bombesin	81,89	gastrin	bombesin	2520	2922	Gene	Gene	Inhibition|nmod|START_ENTITY release|nsubj|Inhibition release|nmod|analogs analogs|compound|END_ENTITY	Inhibition of bombesin-stimulated gastrin release from isolated human G cells by bombesin analogs .
2483358	0	gastrin	34,41	bombesin	82,90	gastrin	bombesin	2520	2922	Gene	Gene	Inhibition|nmod|START_ENTITY release|nsubj|Inhibition release|nmod|antagonists antagonists|compound|END_ENTITY	Inhibition of bombesin-stimulated gastrin release from isolated canine G cells by bombesin antagonists .
2880870	0	gastrin	15,22	bombesin	34,42	gastrin	bombesin	2520	2922	Gene	Gene	Stimulation|nmod|START_ENTITY release|nsubj|Stimulation release|nmod|peptides peptides|compound|END_ENTITY	Stimulation of gastrin release by bombesin and canine gastrin-releasing peptides .
3349493	0	gastrin	48,55	bombesin	28,36	gastrin	bombesin	2520	2922	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|dobj|concentrations	Plasma gastrin responses to bombesin and antral gastrin concentrations in patients with the intestinal type of gastric_cancer .
4011955	0	gastrin	45,52	bombesin	14,22	gastrin	bombesin	2520	2922	Gene	Gene	releases|dobj|START_ENTITY releases|nsubj|Evidence Evidence|dep|END_ENTITY	Evidence that bombesin releases extragastric gastrin in man .
6647889	0	gastrin	76,83	bombesin	26,34	gastrin	bombesin	2520	2922	Gene	Gene	release|compound|START_ENTITY stimulated|dobj|release stimulated|nsubj|effect effect|nmod|atropine atropine|nmod|END_ENTITY	The effect of atropine on bombesin and gastrin_releasing_peptide stimulated gastrin , pancreatic_polypeptide and neurotensin release in man .
7067582	0	gastrin	6,13	bombesin	27,35	gastrin	bombesin	2520	2922	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Serum gastrin responses to bombesin and food in patients with hypergastrinemia .
7255766	0	gastrin	50,57	bombesin	16,24	gastrin	bombesin	2520	2922	Gene	Gene	release|compound|START_ENTITY potency|nmod|release potency|nmod|END_ENTITY	High potency of bombesin for stimulation of human gastrin release and gastric_acid secretion .
24796622	0	gastrin	39,46	chromogranin_A	17,31	gastrin	chromogranin A	2520	1113	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	An evaluation of chromogranin_A versus gastrin and progastrin in gastrinoma diagnosis and control .
12438555	0	gastrin	48,55	cyclooxygenase-2	92,108	gastrin	cyclooxygenase-2	25320(Tax:10116)	29527(Tax:10116)	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Lansoprazole induces mucosal protection through gastrin receptor-dependent up-regulation of cyclooxygenase-2 in rats .
12674216	0	gastrin	13,20	cyclooxygenase-2	42,58	gastrin	cyclooxygenase-2	2520	5743	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|expression expression|nmod|proteins proteins|amod|END_ENTITY	Influence of gastrin on the expression of cyclooxygenase-2 , hepatocyte_growth_factor and apoptosis-related proteins in gastric epithelial cells .
16254046	0	gastrin	66,73	cyclooxygenase-2	15,31	gastrin	cyclooxygenase-2	14459(Tax:10090)	19225(Tax:10090)	Gene	Gene	gastric_mucosal_hypertrophy|nmod|START_ENTITY END_ENTITY|nmod|gastric_mucosal_hypertrophy	Involvement of cyclooxygenase-2 in gastric_mucosal_hypertrophy in gastrin transgenic_mice .
2566164	0	gastrin	18,25	epidermal_growth_factor	38,61	gastrin	epidermal growth factor	2520	1950	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the gastrin promoter by epidermal_growth_factor and neuropeptides .
2869695	0	gastrin	14,21	gastric_inhibitory_peptide	33,59	gastrin	gastric inhibitory peptide	25320(Tax:10116)	25040(Tax:10116)	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Inhibition of gastrin release by gastric_inhibitory_peptide mediated by somatostatin .
10982770	0	gastrin	17,24	gastrin	41,48	gastrin	gastrin	14459(Tax:10090)	14459(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Glycine-extended gastrin synergizes with gastrin 17 to stimulate_acid secretion in gastrin-deficient mice .
10982770	0	gastrin	41,48	gastrin	17,24	gastrin	gastrin	14459(Tax:10090)	14459(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Glycine-extended gastrin synergizes with gastrin 17 to stimulate_acid secretion in gastrin-deficient mice .
322254	0	gastrin	31,38	gastrin	7,14	gastrin	gastrin	2520	2520	Gene	Gene	START_ENTITY|nsubj|cells cells|compound|END_ENTITY	Antral gastrin cells and serum gastrin in achlorhydria .
322254	0	gastrin	7,14	gastrin	31,38	gastrin	gastrin	2520	2520	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nsubj|cells	Antral gastrin cells and serum gastrin in achlorhydria .
4473290	0	gastrin	29,36	gastrin	7,14	gastrin	gastrin	2520	2520	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Blood gastrin analysis by a gastrin RIA kit -RSB- .
4473290	0	gastrin	7,14	gastrin	29,36	gastrin	gastrin	2520	2520	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Blood gastrin analysis by a gastrin RIA kit -RSB- .
7853818	0	gastrin	11,18	gastrin	64,71	gastrin	gastrin	2520	2520	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	-LSB- Levels of gastrin and somatostatin in blood and gastroduodenal gastrin and somatostatin cells in the differentiation of treatment of patients with duodenal ulcer -RSB- .
7853818	0	gastrin	64,71	gastrin	11,18	gastrin	gastrin	2520	2520	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	-LSB- Levels of gastrin and somatostatin in blood and gastroduodenal gastrin and somatostatin cells in the differentiation of treatment of patients with duodenal ulcer -RSB- .
1486611	0	gastrin	63,70	gastrin-releasing_peptide	72,97	gastrin	gastrin-releasing peptide	2520	2922	Gene	Gene	START_ENTITY|appos|polypeptide polypeptide|compound|neurotensin neurotensin|amod|END_ENTITY	Immunocytochemical identification of some regulatory peptides -LRB- gastrin , gastrin-releasing_peptide , neurotensin and vasoactive intestinal polypeptide -RRB- in the Harderian gland of the green frog , Rana esculenta .
2253822	0	gastrin	61,68	gastrin-releasing_peptide	95,120	gastrin	gastrin-releasing peptide	2520	2922	Gene	Gene	release|compound|START_ENTITY vagotomy|nmod|release Effect|nmod|vagotomy induced|nsubj|Effect induced|nmod|END_ENTITY	Effect of parietal cell vagotomy and cholinergic blockade on gastrin release in man induced by gastrin-releasing_peptide .
2467348	0	gastrin	77,84	gastrin-releasing_peptide	14,39	gastrin	gastrin-releasing peptide	25320(Tax:10116)	171101(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of gastrin-releasing_peptide on acid secretion and the release of gastrin , somatostatin , and histamine in the totally isolated , vascularly perfused rat stomach .
2781240	0	gastrin	26,33	gastrin-releasing_peptide	69,94	gastrin	gastrin-releasing peptide	2520	2922	Gene	Gene	release|nmod|START_ENTITY Studies|nmod|release induced|nsubj|Studies induced|nmod|END_ENTITY	Studies of the release of gastrin from the human duodenum induced by gastrin-releasing_peptide .
2884697	0	gastrin	31,38	gastrin-releasing_peptide	59,84	gastrin	gastrin-releasing peptide	25320(Tax:10116)	171101(Tax:10116)	Gene	Gene	release|compound|START_ENTITY stimulation|nmod|release mediated|nsubj|stimulation mediated|nmod|END_ENTITY	Beta-adrenergic stimulation of gastrin release mediated by gastrin-releasing_peptide in rat antral mucosa .
2887118	0	gastrin	49,56	gastrin-releasing_peptide	10,35	gastrin	gastrin-releasing peptide	25320(Tax:10116)	171101(Tax:10116)	Gene	Gene	analogues|nmod|START_ENTITY analogues|amod|END_ENTITY	Effect of gastrin-releasing_peptide analogues on gastrin and somatostatin release from isolated rat stomach .
9178686	0	gastrin	43,50	gastrin-releasing_peptide	14,39	gastrin	gastrin-releasing peptide	2520	2922	Gene	Gene	messenger|compound|START_ENTITY END_ENTITY|nmod|messenger	The effect of gastrin-releasing_peptide on gastrin and somatostatin messenger RNAs in humans infected with Helicobacter_pylori .
2770221	0	gastrin	80,87	gastrin_releasing_peptide	11,36	gastrin	gastrin releasing peptide	2520	2922	Gene	Gene	release|nmod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of gastrin_releasing_peptide and its related peptides on the release of gastrin .
3106128	0	gastrin	52,59	gastrin_releasing_peptide	23,48	gastrin	gastrin releasing peptide	25320(Tax:10116)	171101(Tax:10116)	Gene	Gene	release|compound|START_ENTITY effects|nmod|release effects|nmod|END_ENTITY	Paradoxical effects of gastrin_releasing_peptide on gastrin release and gastric secretion in the rat .
6764509	0	gastrin	34,41	growth_hormone	16,30	gastrin	growth hormone	2520	2688	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of human growth_hormone on gastrin secretion in children with hyposomatotropism .
2906300	0	gastrin	117,124	growth_hormone-releasing_factor	15,46	gastrin	growth hormone-releasing factor	25320(Tax:10116)	29446(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Interaction|dep|role Interaction|nmod|END_ENTITY	Interaction of growth_hormone-releasing_factor and somatostatin on ulcer_healing_and_mucosal_growth in rats : role of gastrin and epidermal_growth_factor .
10409643	0	gastrin	70,77	histidine_decarboxylase	20,43	gastrin	histidine decarboxylase	2520	3067	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Activation of human histidine_decarboxylase gene promoter activity by gastrin is mediated by two distinct nuclear factors .
12372397	0	gastrin	47,54	histidine_decarboxylase	95,118	gastrin	histidine decarboxylase	2520	3067	Gene	Gene	element|compound|START_ENTITY Identification|nmod|element Identification|nmod|promoter promoter|amod|END_ENTITY	Identification and characterization of a third gastrin response element -LRB- GAS-RE3 -RRB- in the human histidine_decarboxylase gene promoter .
3460171	1	gastrin	85,92	histidine_decarboxylase	116,139	gastrin	histidine decarboxylase	25320(Tax:10116)	24443(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects on plasma gastrin and gastric histamine , histidine_decarboxylase activity and ECL cell density in normal and antrectomized rats .
4449071	0	gastrin	26,33	histidine_decarboxylase	64,87	gastrin	histidine decarboxylase	25320(Tax:10116)	24443(Tax:10116)	Gene	Gene	concentration|compound|START_ENTITY Correlation|nmod|concentration END_ENTITY|nsubj|Correlation	Correlation between serum gastrin concentration and rat stomach histidine_decarboxylase activity .
7250317	0	gastrin	8,15	histidine_decarboxylase	46,69	gastrin	histidine decarboxylase	25320(Tax:10116)	24443(Tax:10116)	Gene	Gene	rat|nsubj|START_ENTITY rat|dobj|END_ENTITY	Luminal gastrin does not activate rat stomach histidine_decarboxylase .
8662934	0	gastrin	59,66	histidine_decarboxylase	10,33	gastrin	histidine decarboxylase	2520	3067	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubj|promoter promoter|compound|END_ENTITY	The human histidine_decarboxylase promoter is regulated by gastrin and phorbol_12-myristate_13-acetate through a downstream cis-acting element .
8928792	0	gastrin	53,60	histidine_decarboxylase	4,27	gastrin	histidine decarboxylase	25320(Tax:10116)	24443(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|promoter promoter|compound|END_ENTITY	Rat histidine_decarboxylase promoter is regulated by gastrin through a protein kinase C pathway .
9361993	0	gastrin	89,96	histidine_decarboxylase	47,70	gastrin	histidine decarboxylase	25320(Tax:10116)	24443(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY affecting|dobj|levels suppresses|advcl|affecting suppresses|dobj|activity activity|nmod|END_ENTITY	Glucose suppresses the activity of rat oxyntic histidine_decarboxylase without affecting gastrin levels .
10660591	0	gastrin	59,66	inducible_cAMP_early_repressor	14,44	gastrin	inducible cAMP early repressor	25320(Tax:10116)	25620(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of inducible_cAMP_early_repressor expression by gastrin and cholecystokinin in the pancreatic cell line AR42J .
11932320	0	gastrin	79,86	insulin	70,77	gastrin	insulin	2520	3630	Gene	Gene	cholecystokinin|dep|START_ENTITY cholecystokinin|dep|END_ENTITY	A comparison of the effects of pegvisomant and octreotide on glucose , insulin , gastrin , cholecystokinin , and pancreatic_polypeptide responses to oral glucose and a standard mixed meal .
3057484	0	gastrin	13,20	insulin	35,42	gastrin	insulin	2520	3630	Gene	Gene	role|nmod|START_ENTITY -LSB-|dobj|role -LSB-|advcl|regulating regulating|dobj|secretion secretion|compound|END_ENTITY	-LSB- The role of gastrin in regulating insulin and glucagon secretion in patients with diabetes_mellitus -RSB- .
40312	0	gastrin	30,37	insulin	49,56	gastrin	insulin	2520	3630	Gene	Gene	pH|nmod|START_ENTITY Significance|nmod|pH release|nsubj|Significance release|nmod|hypoglycemia hypoglycemia|compound|END_ENTITY	Significance of antral pH for gastrin release by insulin hypoglycemia in duodenal_ulcer patients .
4888657	0	gastrin	11,18	insulin	37,44	gastrin	insulin	2520	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of gastrin on the release of insulin in vitro .
834973	0	gastrin	54,61	insulin	14,21	gastrin	insulin	2520	3630	Gene	Gene	secretion|nmod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of insulin on food-stimulated secretion of gastrin after parietal cell vagotomy and selective gastric vagotomy .
996432	0	gastrin	23,30	insulin	44,51	gastrin	insulin	2520	3630	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Gastric_acid and serum gastrin responses to insulin and 2-deoxy-d-glucose in duodenal ulcer patients before and after partial gastrectomy .
3995557	0	gastrin	92,99	met-enkephalin	14,28	gastrin	met-enkephalin	2520	5443	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Occurrence of met-enkephalin , met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8 in gastrin cells of hog antral mucosa .
1997467	0	gastrin	13,20	ornithine_decarboxylase	136,159	gastrin	ornithine decarboxylase	2520	4953	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of gastrin , gastrin_receptor blockers , epidermal_growth_factor , and difluoromethylornithine on the growth and the activity of ornithine_decarboxylase of colonic_carcinoma cells .
2409817	0	gastrin	35,42	ornithine_decarboxylase	63,86	gastrin	ornithine decarboxylase	25320(Tax:10116)	24609(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Attenuation of trophic response to gastrin after inhibition of ornithine_decarboxylase .
3138918	0	gastrin	73,80	ornithine_decarboxylase	16,39	gastrin	ornithine decarboxylase	25320(Tax:10116)	24609(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|dep|localization	Gastric mucosal ornithine_decarboxylase : localization and stimulation by gastrin .
8074227	0	gastrin	67,74	ornithine_decarboxylase	31,54	gastrin	ornithine decarboxylase	25320(Tax:10116)	24609(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|induction induction|nmod|activity activity|amod|END_ENTITY	Secretin inhibits induction of ornithine_decarboxylase activity by gastrin in duodenal mucosa and IEC-6 cells .
6103802	0	gastrin	11,18	pancreatic_polypeptide	58,80	gastrin	pancreatic polypeptide	100685087	490944(Tax:9615)	Gene	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Effects of gastrin on circulating levels of somatostatin , pancreatic_polypeptide , and vasoactive intestinal peptide in dogs .
837869	0	gastrin	15,22	parathyroid_hormone	47,66	gastrin	parathyroid hormone	445524(Tax:9823)	399502(Tax:9823)	Gene	Gene	Stimulation|nmod|START_ENTITY secretion|nsubj|Stimulation secretion|nmod|END_ENTITY	Stimulation of gastrin secretion in the pig by parathyroid_hormone and its inhibition by thyrocalcitonin .
8238515	0	gastrin	19,26	pepsinogen	68,78	gastrin	pepsinogen	100345451(Tax:9986)	100328625(Tax:9986)	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion .
6138366	0	gastrin	14,21	secretin	33,41	gastrin	secretin	25320(Tax:10116)	24769(Tax:10116)	Gene	Gene	release|compound|START_ENTITY release|nmod|END_ENTITY	Inhibition of gastrin release by secretin is mediated by somatostatin in cultured rat antral mucosa .
1682134	0	gastrin	40,47	somatostatin	14,26	gastrin	somatostatin	101119230	443006(Tax:9940)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of somatostatin secretion by gastrin - and acid-dependent mechanisms .
1683168	0	gastrin	62,69	somatostatin	24,36	gastrin	somatostatin	25320(Tax:10116)	24797(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|secretion secretion|compound|END_ENTITY	Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus .
2881824	0	gastrin	86,93	somatostatin	49,61	gastrin	somatostatin	445524(Tax:9823)	494469(Tax:9823)	Gene	Gene	control|nmod|START_ENTITY control|nmod|secretion secretion|nmod|secretion secretion|compound|END_ENTITY	Autonomic nervous control of fundic secretion of somatostatin and antral secretion of gastrin and somatostatin in pigs .
6141956	0	gastrin	73,80	somatostatin	11,23	gastrin	somatostatin	100685087	403993(Tax:9615)	Gene	Gene	concentration|compound|START_ENTITY hydrochloric_acid|dobj|concentration hydrochloric_acid|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of somatostatin on gastric hydrochloric_acid secretion and serum gastrin concentration in the dog -RSB- .
6142851	0	gastrin	61,68	somatostatin	13,25	gastrin	somatostatin	100685087	403993(Tax:9615)	Gene	Gene	levels|compound|START_ENTITY suppress|dobj|levels suppress|nsubj|doses doses|nmod|END_ENTITY	Low doses of somatostatin do not suppress postprandial serum gastrin levels in dogs .
6151425	0	gastrin	64,71	somatostatin	22,34	gastrin	somatostatin	2520	6750	Gene	Gene	-RSB-|compound|START_ENTITY secretion|nmod|-RSB- effect|nmod|secretion effect|nmod|END_ENTITY	-LSB- Inhibitory effect of somatostatin on the secretion of duodenal gastrin -RSB- .
863377	0	gastrin	30,37	somatostatin	49,61	gastrin	somatostatin	105260099	101096911	Gene	Gene	release|compound|START_ENTITY induced|dobj|release induced|nmod|END_ENTITY	Inhibition of vagally induced gastrin release by somatostatin in cats .
913912	0	gastrin	34,41	somatostatin	11,23	gastrin	somatostatin	2520	6750	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of somatostatin and human gastrin I on the lower esophageal sphincter in man .
9886974	0	gastrin	53,60	somatostatin	31,43	gastrin	somatostatin	101119230	443006(Tax:9940)	Gene	Gene	stimulation|compound|START_ENTITY prevents|dobj|stimulation prevents|nsubj|elevation elevation|nmod|END_ENTITY	Concurrent elevation of fundic somatostatin prevents gastrin stimulation by GRP .
3743768	0	gastrin	11,18	transferrin	30,41	gastrin	transferrin	2520	7018	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of gastrin to gastric transferrin .
17442673	0	gastrin	20,27	vesicular_monoamine_transporter_type_2	52,90	gastrin	vesicular monoamine transporter type 2	25320(Tax:10116)	25549(Tax:10116)	Gene	Gene	element|compound|START_ENTITY Identification|nmod|element Identification|nmod|promoter promoter|amod|END_ENTITY	Identification of a gastrin response element in the vesicular_monoamine_transporter_type_2 promoter and requirement of 20 S proteasome subunits for transcriptional activity .
10587610	0	gastrin-releasing_peptide	14,39	GRP	41,44	gastrin-releasing peptide	GRP	225642(Tax:10090)	225642(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Modulation of gastrin-releasing_peptide -LRB- GRP -RRB- receptors in insulin secreting cells .
14692689	0	gastrin-releasing_peptide	14,39	GRP	41,44	gastrin-releasing peptide	GRP	615323(Tax:9913)	615323(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of gastrin-releasing_peptide -LRB- GRP -RRB- in the bovine uterus during the estrous cycle .
14997389	0	gastrin-releasing_peptide	32,57	GRP	59,62	gastrin-releasing peptide	GRP	615323(Tax:9913)	615323(Tax:9913)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of gastrin-releasing_peptide -LRB- GRP -RRB- in the uterine gland of cow .
15007209	0	gastrin-releasing_peptide	31,56	GRP	58,61	gastrin-releasing peptide	GRP	615323(Tax:9913)	615323(Tax:9913)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and expression of gastrin-releasing_peptide -LRB- GRP -RRB- in the bovine cervix .
16836584	0	gastrin-releasing_peptide	22,47	GRP	49,52	gastrin-releasing peptide	GRP	225642(Tax:10090)	225642(Tax:10090)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of gastrin-releasing_peptide -LRB- GRP -RRB- in the uteroplacenta of the mouse deer .
24894852	0	gastrin-releasing_peptide	27,52	GRP	54,57	gastrin-releasing peptide	GRP	2922	2922	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of gastrin-releasing_peptide -LRB- GRP -RRB- in normal and cancerous urological tissues .
3704194	0	gastrin-releasing_peptide	43,68	GRP	70,73	gastrin-releasing peptide	GRP	171101(Tax:10116)	171101(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Neuronal localization and motor effects of gastrin-releasing_peptide -LRB- GRP -RRB- in rat uterus .
8963395	0	gastrin-releasing_peptide	10,35	GRP	37,40	gastrin-releasing peptide	GRP	100728828	100728828	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of gastrin-releasing_peptide -LRB- GRP -RRB- on guinea_pig gallbladder contraction in vitro .
9430795	0	gastrin-releasing_peptide	11,36	GRP	38,41	gastrin-releasing peptide	GRP	2922	2922	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of gastrin-releasing_peptide -LRB- GRP -RRB- on the mechanical activity of the human ileocaecal region in vitro .
2166149	0	gastrin-releasing_peptide	14,39	bombesin	47,55	gastrin-releasing peptide	bombesin	2922	2922	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of gastrin-releasing_peptide -LRB- human bombesin -RRB- gene in large cell undifferentiated carcinoma_of_the_lung .
6489083	0	gastrin-releasing_peptide	44,69	bombesin	23,31	gastrin-releasing peptide	bombesin	610154(Tax:9615)	2922	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Comparative effects of bombesin and porcine gastrin-releasing_peptide in the dog .
1486611	0	gastrin-releasing_peptide	72,97	gastrin	63,70	gastrin-releasing peptide	gastrin	2922	2520	Gene	Gene	neurotensin|amod|START_ENTITY polypeptide|compound|neurotensin END_ENTITY|appos|polypeptide	Immunocytochemical identification of some regulatory peptides -LRB- gastrin , gastrin-releasing_peptide , neurotensin and vasoactive intestinal polypeptide -RRB- in the Harderian gland of the green frog , Rana esculenta .
2253822	0	gastrin-releasing_peptide	95,120	gastrin	61,68	gastrin-releasing peptide	gastrin	2922	2520	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Effect Effect|nmod|vagotomy vagotomy|nmod|release release|compound|END_ENTITY	Effect of parietal cell vagotomy and cholinergic blockade on gastrin release in man induced by gastrin-releasing_peptide .
2467348	0	gastrin-releasing_peptide	14,39	gastrin	77,84	gastrin-releasing peptide	gastrin	171101(Tax:10116)	25320(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of gastrin-releasing_peptide on acid secretion and the release of gastrin , somatostatin , and histamine in the totally isolated , vascularly perfused rat stomach .
2781240	0	gastrin-releasing_peptide	69,94	gastrin	26,33	gastrin-releasing peptide	gastrin	2922	2520	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Studies Studies|nmod|release release|nmod|END_ENTITY	Studies of the release of gastrin from the human duodenum induced by gastrin-releasing_peptide .
2884697	0	gastrin-releasing_peptide	59,84	gastrin	31,38	gastrin-releasing peptide	gastrin	171101(Tax:10116)	25320(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|stimulation stimulation|nmod|release release|compound|END_ENTITY	Beta-adrenergic stimulation of gastrin release mediated by gastrin-releasing_peptide in rat antral mucosa .
2887118	0	gastrin-releasing_peptide	10,35	gastrin	49,56	gastrin-releasing peptide	gastrin	171101(Tax:10116)	25320(Tax:10116)	Gene	Gene	analogues|amod|START_ENTITY analogues|nmod|END_ENTITY	Effect of gastrin-releasing_peptide analogues on gastrin and somatostatin release from isolated rat stomach .
9178686	0	gastrin-releasing_peptide	14,39	gastrin	43,50	gastrin-releasing peptide	gastrin	2922	2520	Gene	Gene	START_ENTITY|nmod|messenger messenger|compound|END_ENTITY	The effect of gastrin-releasing_peptide on gastrin and somatostatin messenger RNAs in humans infected with Helicobacter_pylori .
3422472	0	gastrin-releasing_peptide	50,75	growth_hormone	88,102	gastrin-releasing peptide	growth hormone	171101(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|xcomp|suppress suppress|dobj|release release|compound|END_ENTITY	Evidence for a physiological role of hypothalamic gastrin-releasing_peptide to suppress growth_hormone and prolactin release in the rat .
4029082	0	gastrin-releasing_peptide	14,39	growth_hormone	43,57	gastrin-releasing peptide	growth hormone	171101(Tax:10116)	81668(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of gastrin-releasing_peptide on growth_hormone secretion in the rat .
6146511	0	gastrin-releasing_peptide	14,39	growth_hormone	43,57	gastrin-releasing peptide	growth hormone	2922	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Inhibition by gastrin-releasing_peptide of growth_hormone -LRB- GH -RRB- secretion induced by human pancreatic GH-releasing factor in rats .
8275329	0	gastrin-releasing_peptide	74,99	growth_hormone	103,117	gastrin-releasing peptide	growth hormone	171101(Tax:10116)	81668(Tax:10116)	Gene	Gene	action|nmod|START_ENTITY requirements|nmod|action Determination|nmod|requirements Determination|nmod|release release|amod|END_ENTITY	Determination of the structural requirements for the inhibitory action of gastrin-releasing_peptide on growth_hormone release .
8963684	0	gastrin-releasing_peptide	86,111	growth_hormone	46,60	gastrin-releasing peptide	growth hormone	171101(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Role Role|nmod|dopamine dopamine|nmod|control control|nmod|END_ENTITY	Role of dopamine in the inhibitory control of growth_hormone and prolactin release by gastrin-releasing_peptide .
8982099	0	gastrin-releasing_peptide	24,49	interleukin-1_beta	117,135	gastrin-releasing peptide	interleukin-1 beta	2922	3553	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Differential effects of gastrin-releasing_peptide , neuropeptide_Y , somatostatin and vasoactive_intestinal_peptide on interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha production by whole blood cells from healthy young and old subjects .
8982099	0	gastrin-releasing_peptide	24,49	interleukin-6_and_tumor_necrosis_factor-alpha	137,182	gastrin-releasing peptide	interleukin-6 and tumor necrosis factor-alpha	2922	3569;7124	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Differential effects of gastrin-releasing_peptide , neuropeptide_Y , somatostatin and vasoactive_intestinal_peptide on interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha production by whole blood cells from healthy young and old subjects .
2760512	0	gastrin-releasing_peptide	27,52	pancreatic_polypeptide	101,123	gastrin-releasing peptide	pancreatic polypeptide	2922	5539	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of synthetic human gastrin-releasing_peptide on pancreatic exocrine secretion and release of pancreatic_polypeptide in conscious rats .
6622284	0	gastrin-releasing_peptide	28,53	pancreatic_polypeptide	105,127	gastrin-releasing peptide	pancreatic polypeptide	610154(Tax:9615)	490944(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of synthetic porcine gastrin-releasing_peptide on plasma levels of immunoreactive cholecystokinin pancreatic_polypeptide and gastrin in dogs .
26897133	0	gastrin-releasing_peptide_receptor	46,80	GRP-R	82,87	gastrin-releasing peptide receptor	GRP-R	2925	2925	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Pre-clinical evaluation of eight DOTA coupled gastrin-releasing_peptide_receptor -LRB- GRP-R -RRB- ligands for in vivo targeting of receptor-expressing tumors .
22354143	0	gastrin-releasing_peptide_receptor	31,65	GRPR	67,71	gastrin-releasing peptide receptor	GRPR	2925	2925	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of fluorine-labeled gastrin-releasing_peptide_receptor -LRB- GRPR -RRB- agonists and antagonists by LC/MS .
9495364	0	gastrin-releasing_peptide_receptor	26,60	GRP_receptor	62,74	gastrin-releasing peptide receptor	GRP receptor	2925	2925	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	In situ hybridization for gastrin-releasing_peptide_receptor -LRB- GRP_receptor -RRB- expression in prostatic_carcinoma .
7728752	0	gastrin-releasing_peptide_receptor	18,52	bombesin	82,90	gastrin-releasing peptide receptor	bombesin	2925	2922	Gene	Gene	Expression|nmod|START_ENTITY confers|nsubj|Expression confers|xcomp|END_ENTITY	Expression of the gastrin-releasing_peptide_receptor confers a growth response to bombesin in immortalized human bronchial epithelial cells .
8185642	0	gastrin_receptor	65,81	cholecystokinin-B_receptor	33,59	gastrin receptor	cholecystokinin-B receptor	887	887	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of cloned human cholecystokinin-B_receptor as a gastrin_receptor .
1577168	0	gastrin_releasing_peptide	22,47	GRP	49,52	gastrin releasing peptide	GRP	171101(Tax:10116)	171101(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Functional control of gastrin_releasing_peptide -LRB- GRP -RRB- mRNA in rat stomach .
6482663	0	gastrin_releasing_peptide	19,44	GRP	46,49	gastrin releasing peptide	GRP	2922	2922	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of porcine gastrin_releasing_peptide -LRB- GRP -RRB- on canine antral motility and gastrin release in vivo .
3226021	0	gastrin_releasing_peptide	41,66	bombesin	23,31	gastrin releasing peptide	bombesin	2922	2922	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- Contractile effect of bombesin and GRP -LRB- gastrin_releasing_peptide -RRB- related peptides on bladder smooth muscle -RSB- .
7166510	0	gastrin_releasing_peptide	34,59	bombesin	16,24	gastrin releasing peptide	bombesin	2922	2922	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of bombesin and GRP -LRB- gastrin_releasing_peptide -RRB- sequences in gut nerves or endocrine cells .
2770221	0	gastrin_releasing_peptide	11,36	gastrin	80,87	gastrin releasing peptide	gastrin	2922	2520	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of gastrin_releasing_peptide and its related peptides on the release of gastrin .
3106128	0	gastrin_releasing_peptide	23,48	gastrin	52,59	gastrin releasing peptide	gastrin	171101(Tax:10116)	25320(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|release release|compound|END_ENTITY	Paradoxical effects of gastrin_releasing_peptide on gastrin release and gastric secretion in the rat .
6828449	0	gastrin_releasing_peptide	37,62	prolactin	14,23	gastrin releasing peptide	prolactin	171101(Tax:10116)	24683(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of prolactin secretion by gastrin_releasing_peptide -LRB- GRP -RRB- in the rat .
8984045	0	gastroesophageal_reflux	15,38	GER	40,43	gastroesophageal reflux	GER	59330	59330	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of gastroesophageal_reflux -LRB- GER -RRB- with bronchial_asthma .
21323725	0	gastrointestinal_glutathione_peroxidase	27,66	GI-GPx	68,74	gastrointestinal glutathione peroxidase	GI-GPx	14776(Tax:10090)	14776(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Differential expression of gastrointestinal_glutathione_peroxidase -LRB- GI-GPx -RRB- gene during mouse organogenesis .
10806356	0	gastrointestinal_glutathione_peroxidase	37,76	GPX2	78,82	gastrointestinal glutathione peroxidase	GPX2	2877	2877	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Structural organization of the human gastrointestinal_glutathione_peroxidase -LRB- GPX2 -RRB- promoter and 3 ' - nontranscribed region : transcriptional response to exogenous redox agents .
15464585	0	gata2	51,56	Pur_alpha	0,9	gata2	Pur alpha	14461(Tax:10090)	19290(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Pur_alpha and Sp8 as opposing regulators of neural gata2 expression .
16469847	0	gata4	21,26	BCL2	45,49	gata4	BCL2	14463(Tax:10090)	12043(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo .
20044811	0	gata4	48,53	mga	34,37	gata4	mga	2626	23269	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The tbx/bHLH transcription factor mga regulates gata4 and organogenesis .
9928992	0	gcm	100,103	glial_cells_missing	79,98	gcm	glial cells missing	34277(Tax:7227)	34277(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Isolation and expression analysis of a novel human homologue of the Drosophila glial_cells_missing -LRB- gcm -RRB- gene .
10598019	0	gelatin-binding_protein_28	14,40	C/EBP	68,73	gelatin-binding protein 28	C/EBP	9370	1050	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of gelatin-binding_protein_28 -LRB- GBP28 -RRB- gene expression by C/EBP .
12898250	0	gelatinase_A	18,30	MMP-2	32,37	gelatinase A	MMP-2	337179(Tax:7955)	337179(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of gelatinase_A -LRB- MMP-2 -RRB- is required for normal development of zebrafish embryos .
12477525	0	gelatinase_A	21,33	matrix_metalloproteinase_2	35,61	gelatinase A	matrix metalloproteinase 2	81686(Tax:10116)	81686(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|dep|END_ENTITY	Nitric_oxide induces gelatinase_A -LRB- matrix_metalloproteinase_2 -RRB- during rat embryo implantation .
8563023	0	gelatinase_B	35,47	MMP-9	28,33	gelatinase B	MMP-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Developmental expression of MMP-9 -LRB- gelatinase_B -RRB- mRNA in mouse embryos .
15870844	0	gelatinase_B	14,26	matrix_metalloproteinase-9	28,54	gelatinase B	matrix metalloproteinase-9	4318	4318	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition of gelatinase_B -LRB- matrix_metalloproteinase-9 -RRB- by dihydrolipoic_acid .
9466586	0	gelatinase_B	44,56	matrix_metalloproteinase-9	16,42	gelatinase B	matrix metalloproteinase-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Requirement for matrix_metalloproteinase-9 -LRB- gelatinase_B -RRB- expression in metastasis by murine prostate_carcinoma .
12039986	0	gelatinase_a	37,49	Ets-1	21,26	gelatinase a	Ets-1	81686(Tax:10116)	2113	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor Ets-1 regulates gelatinase_a gene expression in mesangial cells .
10228034	0	gelatinases_A_and_B	24,43	kit_ligand	60,70	gelatinases A and B	kit ligand	403885(Tax:9615)	403507(Tax:9615)	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Mast cell expression of gelatinases_A_and_B is regulated by kit_ligand and TGF-beta .
21400204	0	gelsolin	40,48	Flightless_I	24,36	gelsolin	Flightless I	296654(Tax:10116)	287375(Tax:10116)	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	Decreased expression of Flightless_I , a gelsolin family member and developmental regulator , in early-gestation fetal wounds improves healing .
2169737	0	gelsolin	9,17	Ha-ras	71,77	gelsolin	Ha-ras	227753(Tax:10090)	15461(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Elevated gelsolin and alpha-actin expression in a flat revertant R1 of Ha-ras oncogene-transformed NIH/3T3 cells .
17130841	0	gelsolin	92,100	N-RAS	86,91	gelsolin	N-RAS	2934	4893	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS : gelsolin complex .
23940300	0	gelsolin	17,25	Nm23-h1	0,7	gelsolin	Nm23-h1	2934	4830	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis .
11093254	0	gelsolin	35,43	VASP	0,4	gelsolin	VASP	2934	7408	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	VASP protects actin filaments from gelsolin : an in vitro study with implications for platelet actin reorganizations .
17576137	0	gelsolin-like_1	76,91	gsnl1	93,98	gelsolin-like 1	gsnl1	323285(Tax:7955)	323285(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transgenic analysis of the anterior eye-specific enhancers of the zebrafish gelsolin-like_1 -LRB- gsnl1 -RRB- gene .
2843505	1	gene_33	132,139	phosphoenolpyruvate_carboxykinase	74,107	gene 33	phosphoenolpyruvate carboxykinase	54206	5106	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Inhibition of the phosphoenolpyruvate_carboxykinase gene and stimulation of gene_33 in a single cell type .
7876247	0	general_transcription_factor_IIB	38,70	vitamin_D_receptor	4,22	general transcription factor IIB	vitamin D receptor	2959	7421	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The vitamin_D_receptor interacts with general_transcription_factor_IIB .
24747341	0	gephyrin	43,51	Brain-derived_neurotrophic_factor	0,33	gephyrin	Brain-derived neurotrophic factor	64845(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor promotes gephyrin protein expression and GABAA receptor clustering in immature cultured hippocampal cells .
27002143	0	gephyrin	70,78	IQ_Motif_and_SEC7_Domain-containing_Protein_3	0,45	gephyrin	IQ Motif and SEC7 Domain-containing Protein 3	10243	440073	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	IQ_Motif_and_SEC7_Domain-containing_Protein_3 -LRB- IQSEC3 -RRB- interacts with gephyrin to promote inhibitory synapse formation .
19755106	0	gephyrin	85,93	Neuroligin_2	0,12	gephyrin	Neuroligin 2	10243	57555	Gene	Gene	drives|nmod|START_ENTITY drives|nsubj|END_ENTITY	Neuroligin_2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin .
19393317	0	germ_cell-less	27,41	Bruno	0,5	germ cell-less	Bruno	35864(Tax:7227)	34648(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Bruno negatively regulates germ_cell-less expression in a BRE-independent manner .
8620450	0	germ_cell_nuclear_antigen	31,56	GCNA1	58,63	germ cell nuclear antigen	GCNA1	107425(Tax:10090)	107425(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of a specific mouse germ_cell_nuclear_antigen -LRB- GCNA1 -RRB- by early embryonic testicular_teratoma cells in 129/Sv-Sl / + mice .
12729562	0	germ_cell_nuclear_factor	24,48	xGCNF	50,55	germ cell nuclear factor	xGCNF	399304(Tax:8355)	399304(Tax:8355)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	The function of Xenopus germ_cell_nuclear_factor -LRB- xGCNF -RRB- in morphogenetic movements during neurulation .
16431081	0	germinal_center-associated_nuclear_protein	24,66	GANP	68,72	germinal center-associated nuclear protein	GANP	8888	8888	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of germinal_center-associated_nuclear_protein -LRB- GANP -RRB- is associated with malignant_transformation_of_melanocytes .
10477597	0	germinal_center_kinase_related	128,158	TNF_receptor-associated_factor_2	72,104	germinal center kinase related	TNF receptor-associated factor 2	11183	7186	Gene	Gene	recruits|xcomp|START_ENTITY recruits|nsubj|END_ENTITY	TNF-mediated activation of the stress-activated protein kinase pathway : TNF_receptor-associated_factor_2 recruits and activates germinal_center_kinase_related .
11231996	0	gh	96,98	growth_hormone	80,94	gh	growth hormone	2688	2688	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effects of recombinant human insulin-like growth factor I administration on the growth_hormone -LRB- gh -RRB- response to GH-releasing hormone in obesity .
19262695	0	ghrelin	45,52	Akt	16,19	ghrelin	Akt	58991(Tax:10090)	207	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and - dependent mechanisms .
22532145	0	ghrelin	62,69	CB1	33,36	ghrelin	CB1	59301(Tax:10116)	25248(Tax:10116)	Gene	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	Effects of CP 55,940 -- agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas .
15550621	0	ghrelin	49,56	CCK	0,3	ghrelin	CCK	59301(Tax:10116)	25298(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	CCK inhibits the orexigenic effect of peripheral ghrelin .
11069119	0	ghrelin	27,34	Fos	43,46	ghrelin	Fos	59301(Tax:10116)	314322(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY induces|nsubj|administration induces|dobj|proteins proteins|amod|END_ENTITY	Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats .
12023064	0	ghrelin	11,18	Fos	41,44	ghrelin	Fos	58991(Tax:10090)	14281(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus .
14575873	0	ghrelin	29,36	Fos	45,48	ghrelin	Fos	59301(Tax:10116)	314322(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY induces|nsubj|injection induces|dobj|expression expression|compound|END_ENTITY	Intraperitoneal injection of ghrelin induces Fos expression in the paraventricular nucleus of the hypothalamus in rats .
18329635	0	ghrelin	24,31	Fos	40,43	ghrelin	Fos	59301(Tax:10116)	314322(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY induces|nsubj|injection induces|dobj|expression expression|compound|END_ENTITY	Peripheral injection of ghrelin induces Fos expression in the dorsomedial hypothalamic nucleus in rats .
12050285	0	ghrelin	39,46	GHS-R	77,82	ghrelin	GHS-R	59301(Tax:10116)	2693	Gene	Gene	mRNA|nmod|START_ENTITY distribution|nmod|mRNA distribution|nmod|receptor receptor|appos|END_ENTITY	The tissue distribution of the mRNA of ghrelin and subtypes of its receptor , GHS-R , in humans .
16043264	0	ghrelin	65,72	GHS-R	74,79	ghrelin	GHS-R	59301(Tax:10116)	84022(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY localization|nmod|receptor END_ENTITY|nsubj|localization	Immunohistochemical localization of orexin-B , orexin-1 receptor , ghrelin , GHS-R in the lacrimal gland of normal and diabetic rats .
21269967	0	ghrelin	15,22	GHS-R	40,45	ghrelin	GHS-R	59301(Tax:10116)	84022(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	-LSB- Expression of ghrelin and its receptor GHS-R in the hypothalamus and gastrointestinal tract in rats with chronic_renal_failure -RSB- .
24468548	0	ghrelin	40,47	GHS-R	60,65	ghrelin	GHS-R	58991(Tax:10090)	2693	Gene	Gene	analog|nmod|START_ENTITY Characterization|nmod|analog Characterization|nmod|END_ENTITY	Characterization of a far-red analog of ghrelin for imaging GHS-R in P19-derived cardiomyocytes .
21470317	0	ghrelin	25,32	GPR39	0,5	ghrelin	GPR39	58991(Tax:10090)	71111(Tax:10090)	Gene	Gene	family|compound|START_ENTITY receptor|nmod|family END_ENTITY|appos|receptor	GPR39 , a receptor of the ghrelin receptor family , plays a role in the regulation of glucose homeostasis in a mouse model of early onset diet-induced obesity .
17993760	0	ghrelin	57,64	Growth_hormone	0,14	ghrelin	Growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY inhibit|dobj|secretion inhibit|nsubj|END_ENTITY	Growth_hormone and somatostatin directly inhibit gastric ghrelin secretion .
23772680	0	ghrelin	42,49	Growth_hormone	0,14	ghrelin	Growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY modulates|dobj|levels modulates|nsubj|treatment treatment|amod|END_ENTITY	Growth_hormone treatment modulates active ghrelin levels in rats .
16418280	0	ghrelin	38,45	IA-2beta	0,8	ghrelin	IA-2beta	58991(Tax:10090)	19276(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	IA-2beta , but not IA-2 , is induced by ghrelin and inhibits glucose-stimulated insulin secretion .
21081804	0	ghrelin	76,83	IGF-1	40,45	ghrelin	IGF-1	59301(Tax:10116)	24482(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nmod|effect	Role of hormonal axis , growth_hormone - IGF-1 , in the therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis .
16015681	0	ghrelin	16,23	IL-1R1	116,122	ghrelin	IL-1R1	58991(Tax:10090)	16177(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Enhanced plasma ghrelin levels in Helicobacter_pylori-colonized , interleukin-1-receptor type 1-homozygous knockout -LRB- IL-1R1 - / - -RRB- mice .
19477231	0	ghrelin	11,18	Kisspeptin	22,32	ghrelin	Kisspeptin	59301(Tax:10116)	289023(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of ghrelin on Kisspeptin mRNA expression in the hypothalamic medial preoptic area and pulsatile luteinising hormone secretion in the female rat .
22575870	0	ghrelin	11,18	NOD2	32,36	ghrelin	NOD2	59301(Tax:10116)	291912(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-kB activation when protects against acute_lung_injury in rats challenged with cecal_ligation_and_puncture .
25646463	0	ghrelin	39,46	butyrylcholinesterase	7,28	ghrelin	butyrylcholinesterase	58991(Tax:10090)	12038(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Plasma butyrylcholinesterase regulates ghrelin to control aggression .
25646463	0	ghrelin	39,46	butyrylcholinesterase	7,28	ghrelin	butyrylcholinesterase	58991(Tax:10090)	12038(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Plasma butyrylcholinesterase regulates ghrelin to control aggression .
15890776	0	ghrelin	26,33	cholecystokinin	39,54	ghrelin	cholecystokinin	59301(Tax:10116)	25298(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Peripheral interaction of ghrelin with cholecystokinin on feeding regulation .
17360909	0	ghrelin	141,148	cholecystokinin	106,121	ghrelin	cholecystokinin	59301(Tax:10116)	25298(Tax:10116)	Gene	Gene	and_amphetamine-regulated_transcript|nmod|START_ENTITY and_amphetamine-regulated_transcript|nmod|END_ENTITY	Cocaine - _ and_amphetamine-regulated_transcript : stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin .
15582733	0	ghrelin	21,28	corticotropin-releasing_factor	63,93	ghrelin	corticotropin-releasing factor	59301(Tax:10116)	81648(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|nmod|system system|amod|END_ENTITY	Inhibitory effect of ghrelin on food intake is mediated by the corticotropin-releasing_factor system in neonatal chicks .
24524370	0	ghrelin	10,17	erythropoietin	27,41	ghrelin	erythropoietin	59301(Tax:10116)	24335(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of ghrelin on renal erythropoietin production in chronic hypoxic rats .
18514175	0	ghrelin	29,36	fos	45,48	ghrelin	fos	59301(Tax:10116)	314322(Tax:10116)	Gene	Gene	delivery|nmod|START_ENTITY induces|nsubj|delivery induces|dobj|expression expression|compound|END_ENTITY	Caudal brainstem delivery of ghrelin induces fos expression in the nucleus of the solitary tract , but not in the arcuate or paraventricular nuclei of the hypothalamus .
12193546	0	ghrelin	120,127	ghrelin	43,50	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Delayed short-term secretory regulation of ghrelin in obese animals : evidenced by a specific RIA for the active form of ghrelin .
12193546	0	ghrelin	43,50	ghrelin	120,127	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Delayed short-term secretory regulation of ghrelin in obese animals : evidenced by a specific RIA for the active form of ghrelin .
17026962	0	ghrelin	11,18	ghrelin	32,39	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord .
17026962	0	ghrelin	32,39	ghrelin	11,18	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of ghrelin and des-acyl ghrelin on neurogenesis of the rat fetal spinal cord .
17573135	0	ghrelin	13,20	ghrelin	38,45	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds : a microdialysis study .
17573135	0	ghrelin	38,45	ghrelin	13,20	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	cells|compound|START_ENTITY END_ENTITY|nmod|cells	Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds : a microdialysis study .
20584261	0	ghrelin	23,30	ghrelin	44,51	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats .
20584261	0	ghrelin	44,51	ghrelin	23,30	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Contrasting effects of ghrelin and des-acyl ghrelin on the lumbo-sacral defecation center and regulation of colorectal motility in rats .
21611877	0	ghrelin	121,128	ghrelin	17,24	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Long-term plasma ghrelin and leptin modulation after sleeve gastrectomy in Wistar_rats in comparison with gastric tissue ghrelin expression .
21611877	0	ghrelin	17,24	ghrelin	121,128	ghrelin	ghrelin	59301(Tax:10116)	59301(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Long-term plasma ghrelin and leptin modulation after sleeve gastrectomy in Wistar_rats in comparison with gastric tissue ghrelin expression .
10964690	0	ghrelin	45,52	growth_hormone	57,71	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	peptide|appos|START_ENTITY peptide|nmod|release release|amod|END_ENTITY	Central effects of a novel acylated peptide , ghrelin , on growth_hormone release in rats .
11786694	0	ghrelin	33,40	growth_hormone	80,94	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	Purification|nmod|START_ENTITY Purification|dep|endogenous endogenous|acl|ligand ligand|nmod|receptor receptor|amod|END_ENTITY	Purification and distribution of ghrelin : the natural endogenous ligand for the growth_hormone secretagogue receptor .
11849375	0	ghrelin	23,30	growth_hormone	34,48	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	Regulational effect of ghrelin on growth_hormone secretion from perifused rat anterior pituitary cells .
12149581	0	ghrelin	4,11	growth_hormone	23,37	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Rat ghrelin stimulates growth_hormone and prolactin release in the tilapia , Oreochromis_mossambicus .
12624529	0	ghrelin	8,15	growth_hormone	34,48	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|control control|nmod|secretion secretion|amod|END_ENTITY	Role of ghrelin in the control of growth_hormone secretion in prepubertal rats : interactions with excitatory amino_acids .
12650860	0	ghrelin	24,31	growth_hormone	35,49	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	circulating|dobj|START_ENTITY circulating|nmod|END_ENTITY	The role of circulating ghrelin in growth_hormone -LRB- GH -RRB- secretion in freely moving male rats .
12960077	0	ghrelin	68,75	growth_hormone	33,47	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	peptide-6|compound|START_ENTITY pulsatility|nmod|peptide-6 pulsatility|nsubj|suppression suppression|nmod|END_ENTITY	Pattern-dependent suppression of growth_hormone -LRB- GH -RRB- pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats .
14530511	0	ghrelin	65,72	growth_hormone	14,28	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	production|compound|START_ENTITY exerts|nmod|production exerts|nsubj|Evidence Evidence|acl:relcl|END_ENTITY	Evidence that growth_hormone exerts a feedback effect on stomach ghrelin production and secretion .
15087428	0	ghrelin	119,126	growth_hormone	33,47	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression role|dep|regulation role|nmod|ghrelin ghrelin|nmod|secretion secretion|amod|END_ENTITY	The role of pituitary ghrelin in growth_hormone -LRB- GH -RRB- secretion : GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content .
15087428	0	ghrelin	22,29	growth_hormone	33,47	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The role of pituitary ghrelin in growth_hormone -LRB- GH -RRB- secretion : GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content .
15271059	0	ghrelin	66,73	growth_hormone	30,44	ghrelin	growth hormone	58991(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY affect|dobj|expression affect|nsubj|changes changes|nmod|levels levels|compound|END_ENTITY	Chronic changes in peripheral growth_hormone levels do not affect ghrelin stomach mRNA expression and serum ghrelin levels in three transgenic mouse models .
15476443	0	ghrelin	30,37	growth_hormone	49,63	ghrelin	growth hormone	59301(Tax:10116)	2688	Gene	Gene	administration|nmod|START_ENTITY stimulates|nsubj|administration stimulates|dobj|secretion secretion|amod|END_ENTITY	Intravenous administration of ghrelin stimulates growth_hormone secretion in vagotomized patients as well as normal subjects .
15620415	0	ghrelin	11,18	growth_hormone	22,36	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of ghrelin on growth_hormone secretion in vivo in ruminants .
15919752	0	ghrelin	11,18	growth_hormone	38,52	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Endogenous ghrelin regulates episodic growth_hormone -LRB- GH -RRB- secretion by amplifying GH Pulse amplitude : evidence from antagonism of the GH secretagogue-R1a receptor .
16210361	0	ghrelin	31,38	growth_hormone	75,89	ghrelin	growth hormone	442996(Tax:9940)	443329(Tax:9940)	Gene	Gene	infusion|nmod|START_ENTITY Effects|nmod|infusion Effects|nmod|END_ENTITY	Effects of central infusion of ghrelin on food intake and plasma levels of growth_hormone , luteinizing hormone , prolactin , and cortisol secretion in sheep .
16530883	0	ghrelin	13,20	growth_hormone	37,51	ghrelin	growth hormone	58991(Tax:10090)	14599(Tax:10090)	Gene	Gene	-RSB-|dep|START_ENTITY Trp3|appos|-RSB- stimulates|nsubj|Trp3 stimulates|dobj|secretion secretion|amod|END_ENTITY	-LSB- Trp3 , Arg5 -RSB- - ghrelin -LRB- 1-5 -RRB- stimulates growth_hormone secretion and food intake via growth_hormone_secretagogue _ -LRB- GHS -RRB- _ receptor .
17060681	0	ghrelin	19,26	growth_hormone	36,50	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Central effects of ghrelin on serum growth_hormone and morphology of pituitary somatotropes in rats .
17595213	0	ghrelin	11,18	growth_hormone	47,61	ghrelin	growth hormone	58991(Tax:10090)	14599(Tax:10090)	Gene	Gene	administration|compound|START_ENTITY administration|nmod|status status|amod|END_ENTITY	Effects of ghrelin administration on decreased growth_hormone status in obese animals .
18208550	0	ghrelin	96,103	growth_hormone	55,69	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|increase increase|nmod|baseline baseline|acl|circulating circulating|dobj|END_ENTITY	The pregnancy-induced increase in baseline circulating growth_hormone in rats is not induced by ghrelin .
18719021	0	ghrelin	109,116	growth_hormone	35,49	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY using|dobj|agonist demarcation|acl|using demarcation|nmod|motility motility|compound|END_ENTITY	Pharmacological demarcation of the growth_hormone , gut motility and feeding effects of ghrelin using a novel ghrelin receptor agonist .
18719021	0	ghrelin	87,94	growth_hormone	35,49	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	motility|nmod|START_ENTITY motility|compound|END_ENTITY	Pharmacological demarcation of the growth_hormone , gut motility and feeding effects of ghrelin using a novel ghrelin receptor agonist .
20185766	0	ghrelin	39,46	growth_hormone	66,80	ghrelin	growth hormone	58991(Tax:10090)	14599(Tax:10090)	Gene	Gene	circulating|dobj|START_ENTITY reduction|acl|circulating alters|nsubj|reduction alters|dobj|responsiveness responsiveness|amod|END_ENTITY	A postweaning reduction in circulating ghrelin temporarily alters growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing hormone in male mice but does not affect somatic growth .
20437258	0	ghrelin	45,52	growth_hormone	71,85	ghrelin	growth hormone	100861189	102171600	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|release release|amod|END_ENTITY	Purification and characterization of caprine ghrelin and its effect on growth_hormone release .
20814072	0	ghrelin	14,21	growth_hormone	56,70	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|axis axis|nmod|END_ENTITY	Importance of ghrelin in hypothalamus-pituitary axis on growth_hormone release during normal pregnancy in the rat .
21081804	0	ghrelin	76,83	growth_hormone	23,37	ghrelin	growth hormone	59301(Tax:10116)	81668(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY IGF-1|nmod|effect Role|dep|IGF-1 Role|nmod|axis axis|appos|END_ENTITY	Role of hormonal axis , growth_hormone - IGF-1 , in the therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis .
25645493	0	ghrelin	9,16	growth_hormone	60,74	ghrelin	growth hormone	58991(Tax:10090)	14599(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|surge surge|nmod|END_ENTITY	Acylated ghrelin is not required for the surge in pituitary growth_hormone observed in pregnant mice .
23955309	0	ghrelin	109,116	mTOR	29,33	ghrelin	mTOR	59301(Tax:10116)	21977(Tax:10090)	Gene	Gene	focus|nmod|START_ENTITY Modulation|dep|focus Modulation|nmod|intake intake|nmod|END_ENTITY	Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats : focus on ghrelin and nesfatin-1 .
22987245	0	ghrelin	10,17	myostatin	83,92	ghrelin	myostatin	59301(Tax:10116)	29152(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of ghrelin and its analogues , BIM-28131 and BIM-28125 , on the expression of myostatin in a rat heart_failure model .
15616037	0	ghrelin_receptor	77,93	growth_hormone_secretagogue_receptor	39,75	ghrelin receptor	growth hormone secretagogue receptor	2693	2693	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genetic linkage and association of the growth_hormone_secretagogue_receptor -LRB- ghrelin_receptor -RRB- gene in human obesity .
23112170	0	ghrelin_receptor	16,32	somatostatin_receptor-5	46,69	ghrelin receptor	somatostatin receptor-5	2693	6755	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|END_ENTITY	Modification of ghrelin_receptor signaling by somatostatin_receptor-5 regulates insulin release .
10604382	0	glandular_kallikrein_2	99,121	HK2	123,126	glandular kallikrein 2	HK2	3817	3099	Gene	Gene	measurements|nmod|START_ENTITY disease|nmod|measurements those|nmod|disease prostate_cancer|nmod|those men|nmod|prostate_cancer Discrimination|nmod|men Discrimination|appos|END_ENTITY	Discrimination of men with prostate_cancer from those with benign disease by measurements of human glandular_kallikrein_2 -LRB- HK2 -RRB- in serum .
11753974	0	glandular_kallikrein_2	183,205	glandular_kallikrein_2	38,60	glandular kallikrein 2	glandular kallikrein 2	3817	3817	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of human prostate specific glandular_kallikrein_2 and prostate_specific_antigen gene expression in prostate with gene amplification and overexpression of prostate specific glandular_kallikrein_2 in tumor tissue .
11753974	0	glandular_kallikrein_2	38,60	glandular_kallikrein_2	183,205	glandular kallikrein 2	glandular kallikrein 2	3817	3817	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of human prostate specific glandular_kallikrein_2 and prostate_specific_antigen gene expression in prostate with gene amplification and overexpression of prostate specific glandular_kallikrein_2 in tumor tissue .
9187691	0	glandular_kallikrein_2	6,28	hK2	30,33	glandular kallikrein 2	hK2	3817	58164	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Human glandular_kallikrein_2 -LRB- hK2 -RRB- expression in prostatic_intraepithelial_neoplasia and adenocarcinoma : a novel prostate_cancer marker .
21559685	0	gli	25,28	jun	35,38	gli	jun	2735	3725	Gene	Gene	study|nmod|START_ENTITY END_ENTITY|nsubj|study	A study on the oncogenes gli , fos , jun and met in human uterine leiomyomas .
14555646	0	gli-1	93,98	bcl-2	30,35	gli-1	bcl-2	14632(Tax:10090)	12043(Tax:10090)	Gene	Gene	signaling|advcl|START_ENTITY hedgehog|acl|signaling mediated|nmod|hedgehog mediated|nsubj|regulation regulation|nmod|END_ENTITY	Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1 .
1698627	0	glia-derived_nexin	78,96	vitronectin	24,35	glia-derived nexin	vitronectin	5270	7448	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of vitronectin with the cell-secreted protease inhibitor glia-derived_nexin and its thrombin complex .
8798479	0	glia_maturation_factor	88,110	p38_mitogen-activated_protein_kinase	24,60	glia maturation factor	p38 mitogen-activated protein kinase	2764	1432	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	In vitro enhancement of p38_mitogen-activated_protein_kinase activity by phosphorylated glia_maturation_factor .
12093153	0	glial-cell-line-derived_neurotrophic_factor	36,79	Fibroblast_growth_factor-2	0,26	glial-cell-line-derived neurotrophic factor	Fibroblast growth factor-2	2668	2247	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Fibroblast_growth_factor-2 requires glial-cell-line-derived_neurotrophic_factor for exerting its neuroprotective actions on glutamate-lesioned hippocampal neurons .
8854895	0	glial-cell-line-derived_neurotrophic_factor	29,72	GDNF	74,78	glial-cell-line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression and regulation of glial-cell-line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA in human astrocytes in vitro .
21130871	0	glial_cell-derived_neurotrophic_factor	40,78	Basic_fibroblast_growth_factor	0,30	glial cell-derived neurotrophic factor	Basic fibroblast growth factor	25453(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Basic_fibroblast_growth_factor promotes glial_cell-derived_neurotrophic_factor gene expression mediated by activation of ERK5 in rat C6 glioma cells .
20625988	0	glial_cell-derived_neurotrophic_factor	28,66	GDNF	68,72	glial cell-derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of Panax_ginseng on glial_cell-derived_neurotrophic_factor -LRB- GDNF -RRB- expression and spermatogenesis in rats .
23926677	0	glial_cell-derived_neurotrophic_factor	12,50	SCF	54,57	glial cell-derived neurotrophic factor	SCF	25453(Tax:10116)	60427(Tax:10116)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	-LSB- Effects of glial_cell-derived_neurotrophic_factor on SCF protein and antioxidant enzyme activity in the testis of unilateral_cryptorchidism rats -RSB- .
25403360	0	glial_cell-line_derived_neurotrophic_factor	46,89	Calcitonin_gene-related_peptide	0,31	glial cell-line derived neurotrophic factor	Calcitonin gene-related peptide	25453(Tax:10116)	24241(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Calcitonin_gene-related_peptide regulation of glial_cell-line_derived_neurotrophic_factor in differentiated rat myotubes .
8808409	0	glial_cell-line_derived_neurotrophic_factor	24,67	GDNF	69,73	glial cell-line derived neurotrophic factor	GDNF	14573(Tax:10090)	14573(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Embryonic expression of glial_cell-line_derived_neurotrophic_factor -LRB- GDNF -RRB- suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions .
23884957	0	glial_cell_line-derived_neurotrophic_factor	11,54	Artemin	0,7	glial cell line-derived neurotrophic factor	Artemin	14573(Tax:10090)	11876(Tax:10090)	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	Artemin , a glial_cell_line-derived_neurotrophic_factor family member , induces TRPM8-dependent cold_pain .
12684049	0	glial_cell_line-derived_neurotrophic_factor	24,67	Endothelin-1	0,12	glial cell line-derived neurotrophic factor	Endothelin-1	25453(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates glial_cell_line-derived_neurotrophic_factor expression in cultured rat astrocytes .
10426588	0	glial_cell_line-derived_neurotrophic_factor	55,98	GDNF	100,104	glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Infrequent detectable somatic mutations of the RET and glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- genes in human pituitary_adenomas .
10637445	0	glial_cell_line-derived_neurotrophic_factor	24,67	GDNF	69,73	glial cell line-derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Differential effects of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- in the striatum and substantia nigra of the aged Parkinsonian rat .
11600317	0	glial_cell_line-derived_neurotrophic_factor	14,57	GDNF	59,63	glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- in the developing human fetal brain .
11746778	0	glial_cell_line-derived_neurotrophic_factor	27,70	GDNF	72,76	glial cell line-derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats .
15003293	0	glial_cell_line-derived_neurotrophic_factor	24,67	GDNF	69,73	glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	3 ' UTR -LRB- AGG -RRB- n repeat of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene polymorphism in schizophrenia .
16191208	0	glial_cell_line-derived_neurotrophic_factor	32,75	GDNF	77,81	glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Decreased levels of whole blood glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- in remitted patients with mood_disorders .
17331482	0	glial_cell_line-derived_neurotrophic_factor	74,117	GDNF	119,123	glial cell line-derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Administration of amitriptyline attenuates noise-induced hearing_loss via glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- induction .
17897812	0	glial_cell_line-derived_neurotrophic_factor	28,71	GDNF	73,77	glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis of the glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- gene in schizophrenia .
18363829	0	glial_cell_line-derived_neurotrophic_factor	25,68	GDNF	70,74	glial cell line-derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Serotonin -LRB- 5-HT -RRB- induces glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA expression via the transactivation of fibroblast_growth_factor_receptor_2 -LRB- FGFR2 -RRB- in rat C6 glioma cells .
7781171	0	glial_cell_line-derived_neurotrophic_factor	29,72	GDNF	74,78	glial cell line-derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Ontogeny and distribution of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA in rat .
9081633	0	glial_cell_line-derived_neurotrophic_factor	16,59	GDNF	61,65	glial cell line-derived neurotrophic factor	GDNF	25453(Tax:10116)	25453(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA in embryonic rat by in situ hybridization .
9331921	0	glial_cell_line-derived_neurotrophic_factor	14,57	GDNF	59,63	glial cell line-derived neurotrophic factor	GDNF	14573(Tax:10090)	14573(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- mRNA following mechanical injury to mouse striatum .
9870346	0	glial_cell_line-derived_neurotrophic_factor	17,60	GDNF	62,66	glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Up-regulation of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- expression in regenerating muscle fibers in neuromuscular_diseases .
9972821	0	glial_cell_line-derived_neurotrophic_factor	27,70	GDNF	72,76	glial cell line-derived neurotrophic factor	GDNF	2668	2668	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differential regulation of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- expression in human neuroblastoma and glioblastoma cell lines .
12884298	0	glial_cell_line-derived_neurotrophic_factor	24,67	GFRalpha1	86,95	glial cell line-derived neurotrophic factor	GFRalpha1	14573(Tax:10090)	14585(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Possible involvement of glial_cell_line-derived_neurotrophic_factor and its receptor , GFRalpha1 , in survival and maturation of thymocytes .
9448325	0	glial_cell_line-derived_neurotrophic_factor	42,85	GFRalpha3	29,38	glial cell line-derived neurotrophic factor	GFRalpha3	14573(Tax:10090)	14587(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Expression and regulation of GFRalpha3 , a glial_cell_line-derived_neurotrophic_factor family receptor .
22102605	0	glial_cell_line-derived_neurotrophic_factor	26,69	NANOS2	0,6	glial cell line-derived neurotrophic factor	NANOS2	14573(Tax:10090)	378430(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	NANOS2 acts downstream of glial_cell_line-derived_neurotrophic_factor signaling to suppress differentiation of spermatogonial stem cells .
23587883	0	glial_cell_line-derived_neurotrophic_factor	12,55	cyclooxygenase-2	64,80	glial cell line-derived neurotrophic factor	cyclooxygenase-2	25453(Tax:10116)	29527(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Upregulated glial_cell_line-derived_neurotrophic_factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats .
23472740	0	glial_cell_line-derived_neurotrophic_factor	68,111	glutathione_peroxidase-1	16,40	glial cell line-derived neurotrophic factor	glutathione peroxidase-1	25453(Tax:10116)	24404(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Upregulation of glutathione_peroxidase-1 expression and activity by glial_cell_line-derived_neurotrophic_factor promotes high-level protection of PC12 cells against 6-hydroxydopamine and hydrogen_peroxide toxicities .
12761941	0	glial_cell_line-derived_neurotrophic_factor	34,77	neurotrophin-3	92,106	glial cell line-derived neurotrophic factor	neurotrophin-3	100717276	100718910	Gene	Gene	effects|nmod|START_ENTITY combined|nsubj|effects combined|nmod|END_ENTITY	-LSB- Synergetic protective effects of glial_cell_line-derived_neurotrophic_factor combined with neurotrophin-3 in F-actin on hair cell after noise trauma -RSB- .
23651062	0	glial_cell_missing_1	125,145	GCM1	119,123	glial cell missing 1	GCM1	8521	8521	Gene	Gene	stability|appos|START_ENTITY stability|amod|END_ENTITY	RACK1 -LRB- receptor_for_activated_C-kinase_1 -RRB- interacts with FBW2 -LRB- F-box and WD-repeat domain-containing 2 -RRB- to up-regulate GCM1 -LRB- glial_cell_missing_1 -RRB- stability and placental cell migration and invasion .
9928992	0	glial_cells_missing	79,98	gcm	100,103	glial cells missing	gcm	34277(Tax:7227)	34277(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and expression analysis of a novel human homologue of the Drosophila glial_cells_missing -LRB- gcm -RRB- gene .
19257819	0	glial_cells_missing-2	52,73	Calcium-sensing_receptor	0,24	glial cells missing-2	Calcium-sensing receptor	9247	846	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Calcium-sensing_receptor expression is regulated by glial_cells_missing-2 in human parathyroid cells .
20463099	0	glial_cells_missing_homolog_B	11,40	GCMB	42,46	glial cells missing homolog B	GCMB	9247	9247	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A missense glial_cells_missing_homolog_B -LRB- GCMB -RRB- mutation , Asn502His , causes autosomal_dominant_hypoparathyroidism .
10740226	0	glial_fibrillary_acidic_protein	15,46	GFAP	48,52	glial fibrillary acidic protein	GFAP	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expressed in astroglial cells in circadian rhythm under constant lighting conditions in mice .
10799667	0	glial_fibrillary_acidic_protein	33,64	GFAP	66,70	glial fibrillary acidic protein	GFAP	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Ovarian cycle-related changes of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- immunoreactivity in the rat interpeduncular_nucleus .
12083337	0	glial_fibrillary_acidic_protein	77,108	GFAP	110,114	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Testosterone treatment attenuates the effects of facial nerve transection on glial_fibrillary_acidic_protein -LRB- GFAP -RRB- levels in the hamster facial motor nucleus .
1283203	0	glial_fibrillary_acidic_protein	14,45	GFAP	47,51	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- by cultured angiofibroma stroma cells from patients with tuberous_sclerosis .
1457987	0	glial_fibrillary_acidic_protein	36,67	GFAP	69,73	glial fibrillary acidic protein	GFAP	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in rat pineal stalk astrocytes .
15007738	0	glial_fibrillary_acidic_protein	18,49	GFAP	51,55	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of CSF glial_fibrillary_acidic_protein -LRB- GFAP -RRB- as a putative marker for HIV-associated dementia .
16202357	0	glial_fibrillary_acidic_protein	15,46	GFAP	48,52	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- with grading of the neuroglial_tumours .
1723659	0	glial_fibrillary_acidic_protein	32,63	GFAP	65,69	glial fibrillary acidic protein	GFAP	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Developmental expression of the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- gene in the mouse retina .
1772810	0	glial_fibrillary_acidic_protein	42,73	GFAP	75,79	glial fibrillary acidic protein	GFAP	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Reduction of ocular blood flow results in glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in rat retinal M ller cells .
1779136	0	glial_fibrillary_acidic_protein	25,56	GFAP	58,62	glial fibrillary acidic protein	GFAP	101081938	101081938	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Comparative study of the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in toad , kitten and cat sensory ganglia .
1782546	0	glial_fibrillary_acidic_protein	45,76	GFAP	78,82	glial fibrillary acidic protein	GFAP	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Insulin influences astroglial morphology and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in organotypic cultures .
18483855	0	glial_fibrillary_acidic_protein	11,42	GFAP	44,48	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in glial_fibrillary_acidic_protein -LRB- GFAP -RRB- immonureactivity reflect neuronal states .
2229641	0	glial_fibrillary_acidic_protein	16,47	GFAP	49,53	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in the intermediate filaments of the cultured cells from a patient with tuberous_sclerosis .
22362931	0	glial_fibrillary_acidic_protein	36,67	GFAP	69,73	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Aberrant E-cadherin , b-catenin , and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in canine choroid_plexus_tumors .
23626774	0	glial_fibrillary_acidic_protein	16,47	GFAP	49,53	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Blood levels of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in patients with neurological_diseases .
23991052	0	glial_fibrillary_acidic_protein	35,66	GFAP	68,72	glial fibrillary acidic protein	GFAP	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative mRNA splicing from the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- gene generates isoforms with distinct subcellular mRNA localization patterns in astrocytes .
26518540	0	glial_fibrillary_acidic_protein	32,63	GFAP	65,69	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Prospective evaluation of serum glial_fibrillary_acidic_protein -LRB- GFAP -RRB- as a diagnostic marker for glioblastoma .
2732098	0	glial_fibrillary_acidic_protein	48,79	GFAP	81,85	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunogold electron microscopic localization of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in neurohypophyseal pituicytes and tanycytes of the Mongolian gerbil -LRB- Meriones unguiculatus -RRB- .
2989328	0	glial_fibrillary_acidic_protein	14,45	GFAP	47,51	glial fibrillary acidic protein	GFAP	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression in CNS development and in pathological states .
3124642	0	glial_fibrillary_acidic_protein	14,45	GFAP	47,51	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in peripheral_nerve_sheath_tumors .
3886073	0	glial_fibrillary_acidic_protein	35,66	GFAP	68,72	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in the area postrema of the cat .
4056822	0	glial_fibrillary_acidic_protein	42,73	GFAP	75,79	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	High cerebrospinal fluid concentration of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in patients with normal pressure hydrocephalus .
624958	0	glial_fibrillary_acidic_protein	17,48	GFAP	50,54	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in human brain_tumors .
6339423	0	glial_fibrillary_acidic_protein	11,42	GFAP	44,48	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A study of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in childhood brain_tumours .
7541474	0	glial_fibrillary_acidic_protein	40,71	GFAP	73,77	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	PKA and PKC activation induces opposite glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression and morphology changes in a glioblastoma multiform cell line of clonal origin .
7782103	0	glial_fibrillary_acidic_protein	61,92	GFAP	94,98	glial fibrillary acidic protein	GFAP	14580(Tax:10090)	14580(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Indicator expression directed by regulatory sequences of the glial_fibrillary_acidic_protein -LRB- GFAP -RRB- gene : in vivo comparison of distinct GFAP-lacZ transgenes .
8261795	0	glial_fibrillary_acidic_protein	26,57	GFAP	59,63	glial fibrillary acidic protein	GFAP	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Muller cell expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in RPE-cell transplanted retinas of RCS dystrophic rats .
8552312	0	glial_fibrillary_acidic_protein	27,58	GFAP	60,64	glial fibrillary acidic protein	GFAP	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of glial_fibrillary_acidic_protein -LRB- GFAP -RRB- in the retinae and visual cortices of rats with experimental renal hypertension .
8849315	0	glial_fibrillary_acidic_protein	60,91	GFAP	93,97	glial fibrillary acidic protein	GFAP	24387(Tax:10116)	24387(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Distribution of growth associated protein -LRB- B-50 / GAP-43 -RRB- and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- immunoreactivity in rat homotopic olfactory bulb transplants .
9151729	0	glial_fibrillary_acidic_protein	86,117	GFAP	119,123	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Neuritic outgrowth associated with astroglial phenotypic changes induced by antisense glial_fibrillary_acidic_protein -LRB- GFAP -RRB- mRNA in injured neuron-astrocyte cocultures .
9518557	0	glial_fibrillary_acidic_protein	22,53	GFAP	55,59	glial fibrillary acidic protein	GFAP	2670	2670	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of c-Fos and glial_fibrillary_acidic_protein -LRB- GFAP -RRB- expression following topical application of potassium_chloride -LRB- KCl -RRB- to the brain surface .
16806201	0	glial_fibrillary_acidic_protein	45,76	GRP78-binding_protein	0,21	glial fibrillary acidic protein	GRP78-binding protein	24387(Tax:10116)	338474(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GRP78-binding_protein regulates cAMP-induced glial_fibrillary_acidic_protein expression in rat C6 glioblastoma cells .
3265770	0	glial_fibrillary_acidic_protein	80,111	MPTP	18,22	glial fibrillary acidic protein	MPTP	14580(Tax:10090)	19255(Tax:10090)	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	The neurotoxicant MPTP -LRB- 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine -RRB- increases glial_fibrillary_acidic_protein and decreases dopamine levels of the mouse striatum : evidence for glial response to injury .
20881288	0	glial_fibrillary_acidic_protein	29,60	alpha2-Macroglobulin	0,20	glial fibrillary acidic protein	alpha2-Macroglobulin	14580(Tax:10090)	232345(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	alpha2-Macroglobulin induces glial_fibrillary_acidic_protein expression mediated by low-density_lipoprotein_receptor-related_protein_1 in M ller cells .
15769312	0	glial_fibrillary_acidic_protein	62,93	basic_fibroblast_growth_factor	10,40	glial fibrillary acidic protein	basic fibroblast growth factor	24387(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of basic_fibroblast_growth_factor on the expression of glial_fibrillary_acidic_protein after tractive spinal_cord_injury in rats .
23408790	0	glial_fibrillary_acidic_protein	57,88	nerve_growth_factor	16,35	glial fibrillary acidic protein	nerve growth factor	14580(Tax:10090)	18049(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of mouse nerve_growth_factor on the expression of glial_fibrillary_acidic_protein in hippocampus of neonatal rats with hypoxic-ischemic_brain_damage .
24275526	0	glial_glutamate_transporter	42,69	Glycogen_synthase_kinase_3_beta	0,31	glial glutamate transporter	Glycogen synthase kinase 3 beta	29483(Tax:10116)	84027(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase_3_beta regulates glial_glutamate_transporter protein expression in the spinal dorsal horn in rats with neuropathic_pain .
24256316	0	glial_growth_factor	13,32	Neuregulin-1	0,12	glial growth factor	Neuregulin-1	3084	3084	Gene	Gene	stimulates|nsubj|START_ENTITY END_ENTITY|parataxis|stimulates	Neuregulin-1 / glial_growth_factor stimulates Schwann cell migration by inducing a5 b1 integrin-ErbB2-focal_adhesion_kinase complex formation .
25252859	0	glioma-associated_oncogene_homolog_1	16,52	GLI1	54,58	glioma-associated oncogene homolog 1	GLI1	2735	2735	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Significance of glioma-associated_oncogene_homolog_1 -LRB- GLI1 -RRB- expression in claudin-low breast_cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells -LRB- NF B -RRB- pathway .
1912570	0	globin	40,46	Sp1	15,18	globin	Sp1	41930(Tax:7227)	6667	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Interaction of Sp1 with the human gamma globin promoter : binding and transactivation of normal and mutant promoters .
26004871	0	globotriaosylceramide	62,83	glucosylceramide_synthase	10,35	globotriaosylceramide	glucosylceramide synthase	53947	7357	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Targeting glucosylceramide_synthase induction of cell surface globotriaosylceramide -LRB- Gb3 -RRB- in acquired cisplatin-resistance of lung_cancer and malignant_pleural_mesothelioma cells .
12702662	0	glp-1	34,39	POS-1	48,53	glp-1	POS-1	176286(Tax:6239)	179224(Tax:6239)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis_elegans .
16931572	0	glucagon-like_Peptide_1_receptor	62,94	Caveolin-1	0,10	glucagon-like Peptide 1 receptor	Caveolin-1	2740	857	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Caveolin-1 regulates cellular trafficking and function of the glucagon-like_Peptide_1_receptor .
14574347	0	glucagon-like_peptide-1	22,45	GLP-1	47,52	glucagon-like peptide-1	GLP-1	2641	2641	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Racial differences in glucagon-like_peptide-1 -LRB- GLP-1 -RRB- concentrations and insulin dynamics during oral glucose tolerance test in obese subjects .
17184947	0	glucagon-like_peptide-1	48,71	GLP-1	73,78	glucagon-like peptide-1	GLP-1	14526(Tax:10090)	14526(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Beneficial effects of sub-chronic activation of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors on deterioration of glucose homeostasis and insulin secretion in aging mice .
22353624	0	glucagon-like_peptide-1	28,51	GLP-1	53,58	glucagon-like peptide-1	GLP-1	2641	2641	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Comparison of plasma active glucagon-like_peptide-1 -LRB- GLP-1 -RRB- levels assayed with or without plasma extraction in non-diabetic men .
22938097	0	glucagon-like_peptide-1	18,41	GLP-1	43,48	glucagon-like peptide-1	GLP-1	2641	2641	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in neuroprotection .
3304721	0	glucagon-like_peptide-1	26,49	GLP-1	51,56	glucagon-like peptide-1	GLP-1	2641	2641	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	A large molecular form of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- immunoreactivity is co-released with glucagon from pancreas by arginine in normal subjects .
8839251	0	glucagon-like_peptide-1	11,34	GLP-1	36,41	glucagon-like peptide-1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in RINm5F_insulinoma cells .
8863504	0	glucagon-like_peptide-1	18,41	GLP-1	43,48	glucagon-like peptide-1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Colocalization of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- receptors , glucose transporter GLUT-2 , and glucokinase mRNAs in rat hypothalamic cells : evidence for a role of GLP-1_receptor agonists as an inhibitory signal for food and water intake .
9094161	0	glucagon-like_peptide-1	36,59	GLP-1	61,66	glucagon-like peptide-1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Reciprocal cellular distribution of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- immunoreactivity and GLP-1_receptor mRNA in pancreatic islets of rat .
9134052	0	glucagon-like_peptide-1	11,34	GLP-1	36,41	glucagon-like peptide-1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- by carbohydrates in the perfused rat ileum .
17065340	0	glucagon-like_peptide-1	45,68	Ghrelin	0,7	glucagon-like peptide-1	Ghrelin	24952(Tax:10116)	59301(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY attenuates|dobj|effects attenuates|nsubj|END_ENTITY	Ghrelin attenuates the inhibitory effects of glucagon-like_peptide-1 and peptide_YY -LRB- 3-36 -RRB- on food intake and gastric emptying in rats .
21904878	0	glucagon-like_peptide-1	75,98	Insulin	0,7	glucagon-like peptide-1	Insulin	2641	3630	Gene	Gene	fine-tuning|nmod|START_ENTITY contributes|xcomp|fine-tuning contributes|nsubj|END_ENTITY	Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like_peptide-1 .
9921815	0	glucagon-like_peptide-1	52,75	Insulin	0,7	glucagon-like peptide-1	Insulin	2641	3630	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|calcium calcium|compound|END_ENTITY	Insulin and intracellular calcium responsiveness to glucagon-like_peptide-1 and pituitary_adenylate_cyclase-activating_peptide by dispersed adult porcine islet cells .
25128166	0	glucagon-like_peptide-1	19,42	NADPH_oxidase	52,65	glucagon-like peptide-1	NADPH oxidase	24952(Tax:10116)	66021(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	AMPK activation by glucagon-like_peptide-1 prevents NADPH_oxidase activation induced by hyperglycemia in adult cardiomyocytes .
23437377	0	glucagon-like_peptide-1	31,54	Osteocalcin	0,11	glucagon-like peptide-1	Osteocalcin	14526(Tax:10090)	12097(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Osteocalcin induces release of glucagon-like_peptide-1 and thereby stimulates insulin secretion in mice .
22807616	0	glucagon-like_peptide-1	31,54	Uncoupling_protein_2	0,20	glucagon-like peptide-1	Uncoupling protein 2	2641	7351	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Uncoupling_protein_2 regulates glucagon-like_peptide-1 secretion in L-cells .
15528268	0	glucagon-like_peptide-1	20,43	beta-arrestin_2	53,68	glucagon-like peptide-1	beta-arrestin 2	2641	409	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Characterization of glucagon-like_peptide-1 receptor beta-arrestin_2 interaction : a high-affinity receptor phenotype .
12397536	0	glucagon-like_peptide-1	50,73	growth_hormone	10,24	glucagon-like peptide-1	growth hormone	24952(Tax:10116)	81668(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Effect of growth_hormone on high plasma levels of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in hypophysectomized rats .
12193567	0	glucagon-like_peptide-1	81,104	insulin	133,140	glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	encoding|nmod|START_ENTITY beta-cells|nmod|encoding Transfection|nmod|beta-cells regulates|nsubj|Transfection regulates|dobj|synthesis synthesis|compound|END_ENTITY	Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like_peptide-1 regulates glucose-dependent insulin synthesis and secretion .
16091500	0	glucagon-like_peptide-1	119,142	insulin	32,39	glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	diabetes|amod|START_ENTITY administration|nmod|diabetes pulses|dobj|administration pulses|nsubj|analysis analysis|nmod|END_ENTITY	Deconvolution analysis of rapid insulin pulses before and after six weeks of continuous subcutaneous administration of glucagon-like_peptide-1 in elderly patients with type 2 diabetes .
18792870	0	glucagon-like_peptide-1	33,56	insulin	118,125	glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	role|nmod|START_ENTITY associated|nsubj|role associated|nmod|resistance resistance|compound|END_ENTITY	The potential beneficial role of glucagon-like_peptide-1 in endothelial_dysfunction and heart_failure associated with insulin resistance .
26759261	0	glucagon-like_peptide-1	43,66	insulin	68,75	glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	C-peptide|compound|START_ENTITY C-peptide|dep|END_ENTITY	Effect of meal composition on postprandial glucagon-like_peptide-1 , insulin , glucagon , C-peptide , and glucose responses in overweight/obese subjects .
7627258	0	glucagon-like_peptide-1	88,111	insulin	17,24	glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	amide|amod|START_ENTITY role|nmod|amide secretion|dep|role secretion|compound|END_ENTITY	Highly increased insulin secretion in a patient with postprandial_hypoglycemia : role of glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide .
8819215	0	glucagon-like_peptide-1	35,58	insulin	110,117	glucagon-like peptide-1	insulin	2641	3630	Gene	Gene	correlates|amod|START_ENTITY hormones|dobj|correlates hormones|nmod|secretion secretion|compound|END_ENTITY	Secretion of the incretin hormones glucagon-like_peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day .
21756815	0	glucagon-like_peptide-1	12,35	pancreatic_derived_factor	81,106	glucagon-like peptide-1	pancreatic derived factor	14526(Tax:10090)	52793(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of glucagon-like_peptide-1 on the free fatty_acid-induced expression of pancreatic_derived_factor in cultured b-TC3 cell line -RSB- .
21677044	0	glucagon-like_peptide-1	101,124	visfatin	23,31	glucagon-like peptide-1	visfatin	2641	10135	Gene	Gene	effect|nmod|START_ENTITY evidence|nmod|effect evidence|nmod|suppression suppression|nmod|END_ENTITY	In vivo suppression of visfatin by oral glucose uptake : evidence for a novel incretin-like effect by glucagon-like_peptide-1 -LRB- GLP-1 -RRB- .
11845326	0	glucagon-like_peptide-1_receptor	23,55	INS-1	59,64	glucagon-like peptide-1 receptor	INS-1	25051(Tax:10116)	24505(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Over-expression of the glucagon-like_peptide-1_receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity : a strategy for production of pancreatic beta-cell lines for use in transplantation .
16448646	0	glucagon-like_peptide-2	20,43	GLP-2	45,50	glucagon-like peptide-2	GLP-2	2641	2641	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Naturally occurring glucagon-like_peptide-2 -LRB- GLP-2 -RRB- receptors in human intestinal cell lines .
16890611	0	glucagon-like_peptide-2	87,110	insulin-like_growth_factor-1	22,50	glucagon-like peptide-2	insulin-like growth factor-1	93896(Tax:10090)	16000(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The essential role of insulin-like_growth_factor-1 in the intestinal tropic effects of glucagon-like_peptide-2 in mice .
11181533	0	glucagon-like_peptide_1	23,46	GLP-1	48,53	glucagon-like peptide 1	GLP-1	24952(Tax:10116)	24952(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Insulinotropic hormone glucagon-like_peptide_1 -LRB- GLP-1 -RRB- activation of insulin gene promoter inhibited by p38_mitogen-activated_protein_kinase .
22965295	0	glucagon-like_peptide_1	8,31	GLP-1	33,38	glucagon-like peptide 1	GLP-1	2641	2641	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	A local glucagon-like_peptide_1 -LRB- GLP-1 -RRB- system in human pancreatic islets .
23909258	0	glucagon-like_peptide_1	19,42	GLP-1	12,17	glucagon-like peptide 1	GLP-1	2641	2641	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of GLP-1 -LRB- glucagon-like_peptide_1 -RRB- on liver -RSB- .
8650968	0	glucagon-like_peptide_1	11,34	GLP-1	36,41	glucagon-like peptide 1	GLP-1	2641	100125288	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	Release of glucagon-like_peptide_1 -LRB- GLP-1 -LSB- 7-36 amide -RSB- -RRB- , gastric inhibitory polypeptide -LRB- GIP -RRB- and insulin in response to oral glucose after upper and lower intestinal resections .
19116343	0	glucagon-like_peptide_1	81,104	Pax6	0,4	glucagon-like peptide 1	Pax6	14526(Tax:10090)	18508(Tax:10090)	Gene	Gene	causes|nmod|START_ENTITY causes|nsubj|END_ENTITY	Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating glucagon-like_peptide_1 in mice .
22257551	0	glucagon-like_peptide_1	58,81	Uncoupling_protein_2	0,20	glucagon-like peptide 1	Uncoupling protein 2	2641	7351	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Uncoupling_protein_2 negatively regulates glucose-induced glucagon-like_peptide_1 secretion .
7628397	0	glucagon-like_peptide_1	74,97	dipeptidyl_peptidase_IV	122,145	glucagon-like peptide 1	dipeptidyl peptidase IV	24952(Tax:10116)	25253(Tax:10116)	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of glucose-dependent_insulinotropic_polypeptide and truncated glucagon-like_peptide_1 in vitro and in vivo by dipeptidyl_peptidase_IV .
7813861	0	glucagon-like_peptide_1	39,62	peptide_YY	14,24	glucagon-like peptide 1	peptide YY	24952(Tax:10116)	287730(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Secretion of peptide_YY and truncated glucagon-like_peptide_1 by isolated intestinal cells in rats -RSB- .
25200998	0	glucagon-like_peptide_1_receptor	34,66	GLP-1	76,81	glucagon-like peptide 1 receptor	GLP-1	2740	100125288	Gene	Gene	START_ENTITY|nmod|levels levels|compound|END_ENTITY	Role of rs6923761 gene variant in glucagon-like_peptide_1_receptor in basal GLP-1 levels , cardiovascular_risk factor and serum adipokine levels in na ve type 2 diabetic patients .
22417644	0	glucagon-like_peptide_1_receptor	20,52	GLP1R	54,59	glucagon-like peptide 1 receptor	GLP1R	428573(Tax:9031)	428573(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of glucagon-like_peptide_1_receptor -LRB- GLP1R -RRB- gene in chickens : functional analysis , tissue distribution , and identification of its transcript variants .
24906922	0	glucagon-like_peptide_2_receptor	20,52	GLP2R	54,59	glucagon-like peptide 2 receptor	GLP2R	427787(Tax:9031)	427787(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of glucagon-like_peptide_2_receptor -LRB- GLP2R -RRB- gene in chickens : functional analysis , tissue distribution , and developmental expression profile of GLP2R in embryonic intestine .
15325338	0	glucocerebrosidase	48,66	GBA	68,71	glucocerebrosidase	GBA	2629	2629	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Comparative and genetic analysis of the porcine glucocerebrosidase -LRB- GBA -RRB- gene .
21175417	0	glucocorticoid-induced_TNFR-related_protein	12,55	GITR_ligand	63,74	glucocorticoid-induced TNFR-related protein	GITR ligand	8784	8995	Gene	Gene	Role|nmod|START_ENTITY Role|dep|pathway pathway|compound|END_ENTITY	Role of the glucocorticoid-induced_TNFR-related_protein -LRB- GITR -RRB- - GITR_ligand pathway in innate and adaptive immunity .
15705665	0	glucocorticoid-induced_leucine_zipper	76,113	FoxO3	0,5	glucocorticoid-induced leucine zipper	FoxO3	1831	2309	Gene	Gene	expression|amod|START_ENTITY mediates|nmod|expression mediates|nsubj|END_ENTITY	FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced_leucine_zipper expression .
19875485	0	glucocorticoid-induced_leucine_zipper	4,41	GILZ	48,52	glucocorticoid-induced leucine zipper	GILZ	1831	1831	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The glucocorticoid-induced_leucine_zipper gene -LRB- GILZ -RRB- expression decreases after successful treatment of patients with endogenous Cushing 's _ syndrome and may play a role in glucocorticoid-induced_osteoporosis .
20970683	0	glucocorticoid-induced_leucine_zipper	8,45	GILZ	47,51	glucocorticoid-induced leucine zipper	GILZ	1831	1831	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Role of glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- expression by dendritic cells in tolerance induction .
23090754	0	glucocorticoid-induced_leucine_zipper	14,51	GILZ	53,57	glucocorticoid-induced leucine zipper	GILZ	83514(Tax:10116)	83514(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- in cardiomyocytes .
23494955	0	glucocorticoid-induced_leucine_zipper	30,67	GILZ	69,73	glucocorticoid-induced leucine zipper	GILZ	1831	1831	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants in the human glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- gene in fertile and infertile men .
24860090	0	glucocorticoid-induced_leucine_zipper	8,45	GILZ	47,51	glucocorticoid-induced leucine zipper	GILZ	14605(Tax:10090)	14605(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of glucocorticoid-induced_leucine_zipper -LRB- GILZ -RRB- in bone acquisition .
14499479	0	glucocorticoid-induced_receptor	70,101	GIR	103,106	glucocorticoid-induced receptor	GIR	14608(Tax:10090)	14608(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Acute oral dexamethasone administration reduces levels of orphan GPCR glucocorticoid-induced_receptor -LRB- GIR -RRB- mRNA in rodent brain : potential role in HPA-axis function .
15545613	0	glucocorticoid_receptor	62,85	AF1	86,89	glucocorticoid receptor	AF1	2908	3460	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	TATA_box_binding_protein induces structure in the recombinant glucocorticoid_receptor AF1 domain .
17655821	0	glucocorticoid_receptor	103,126	AF1	91,94	glucocorticoid receptor	AF1	2908	3460	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of different osmolytes on the induced folding of the N-terminal activation domain -LRB- AF1 -RRB- of the glucocorticoid_receptor .
21760925	0	glucocorticoid_receptor	35,58	AF1	59,62	glucocorticoid receptor	AF1	2908	3460	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	TBP binding-induced folding of the glucocorticoid_receptor AF1 domain facilitates its interaction with steroid_receptor_coactivator-1 .
22003412	0	glucocorticoid_receptor	72,95	AF1	38,41	glucocorticoid receptor	AF1	2908	3460	Gene	Gene	domain|nmod|START_ENTITY transactivation|dobj|domain transactivation|nsubj|regulation regulation|nmod|END_ENTITY	Binding-folding induced regulation of AF1 transactivation domain of the glucocorticoid_receptor by a cofactor that binds to its DNA binding domain .
22328717	0	glucocorticoid_receptor	15,38	BRCA1	86,91	glucocorticoid receptor	BRCA1	2908	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
26442220	0	glucocorticoid_receptor	27,50	BRCA1	98,103	glucocorticoid receptor	BRCA1	2908	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Commentary : The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
21093928	0	glucocorticoid_receptor	21,44	Bcl1	59,63	glucocorticoid receptor	Bcl1	2908	595	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Contributions of the glucocorticoid_receptor polymorphism -LRB- Bcl1 -RRB- and childhood abuse to risk of bulimia_nervosa .
19141540	0	glucocorticoid_receptor	90,113	CLOCK	38,43	glucocorticoid receptor	CLOCK	2908	9575	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid_receptor by acetylating its hinge region lysine cluster : potential physiological implications .
21980503	0	glucocorticoid_receptor	41,64	CLOCK	11,16	glucocorticoid receptor	CLOCK	2908	9575	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Peripheral CLOCK regulates target-tissue glucocorticoid_receptor transcriptional activity in a circadian fashion in man .
17602195	0	glucocorticoid_receptor	65,88	CTGF	20,24	glucocorticoid receptor	CTGF	2908	1490	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|END_ENTITY	Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid_receptor .
12477485	0	glucocorticoid_receptor	33,56	CYP3A4	223,229	glucocorticoid receptor	CYP3A4	2908	1576	Gene	Gene	Molecular|nmod|START_ENTITY Molecular|dep|relationships relationships|nmod|series series|nmod|inducers inducers|nummod|END_ENTITY	Molecular modelling of the human glucocorticoid_receptor -LRB- hGR -RRB- ligand-binding_domain -LRB- LBD -RRB- by homology with the human estrogen_receptor_alpha -LRB- hERalpha -RRB- LBD : quantitative structure-activity relationships within a series of CYP3A4 inducers where induction is mediated via hGR involvement .
12673034	1	glucocorticoid_receptor	111,134	CYP3A4	86,92	glucocorticoid receptor	CYP3A4	2908	1576	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association between induction of CYP3A4 and expression of glucocorticoid_receptor .
25141173	0	glucocorticoid_receptor	94,117	CYP3A4	47,53	glucocorticoid receptor	CYP3A4	2908	1576	Gene	Gene	hepatocytes|nmod|START_ENTITY END_ENTITY|nmod|hepatocytes	Omeprazole and lansoprazole enantiomers induce CYP3A4 in human hepatocytes and cell lines via glucocorticoid_receptor and pregnane X receptor axis .
9787404	0	glucocorticoid_receptor	19,42	EGF	58,61	glucocorticoid receptor	EGF	2908	1950	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
3107554	0	glucocorticoid_receptor	69,92	Epidermal_growth_factor	0,23	glucocorticoid receptor	Epidermal growth factor	2908	1950	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates tyrosine phosphorylation of human glucocorticoid_receptor in cultured cells .
23228967	0	glucocorticoid_receptor	97,120	FBXW7	0,5	glucocorticoid receptor	FBXW7	2908	55294	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	FBXW7 regulates glucocorticoid response in T-cell_acute_lymphoblastic_leukaemia by targeting the glucocorticoid_receptor for degradation .
22328717	0	glucocorticoid_receptor	15,38	GABP_beta	100,109	glucocorticoid receptor	GABP beta	2908	2553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
26442220	0	glucocorticoid_receptor	27,50	GABP_beta	112,121	glucocorticoid receptor	GABP beta	2908	2553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Commentary : The unliganded glucocorticoid_receptor positively regulates the tumor suppressor gene BRCA1 through GABP_beta .
12562397	0	glucocorticoid_receptor	33,56	GCR	58,61	glucocorticoid receptor	GCR	2908	2908	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Flow cytometric determination of glucocorticoid_receptor -LRB- GCR -RRB- expression in lymphocyte subpopulations : lower quantity of GCR in patients with post-traumatic_stress_disorder -LRB- PTSD -RRB- .
23440419	0	glucocorticoid_receptor	20,43	GILZ	82,86	glucocorticoid receptor	GILZ	2908	1831	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	DC-SCRIPT regulates glucocorticoid_receptor function and expression of its target GILZ in dendritic cells .
23814048	0	glucocorticoid_receptor	15,38	GR	40,42	glucocorticoid receptor	GR	2908	2908	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
25755906	0	glucocorticoid_receptor	12,35	GR	37,39	glucocorticoid receptor	GR	2908	2908	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of glucocorticoid_receptor -LRB- GR -RRB- polymorphisms in human erythropoiesis .
25762479	0	glucocorticoid_receptor	40,63	GR	65,67	glucocorticoid receptor	GR	2908	2908	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical and biological significance of glucocorticoid_receptor -LRB- GR -RRB- expression in breast_cancer .
15941832	0	glucocorticoid_receptor	55,78	HEXIM1	0,6	glucocorticoid receptor	HEXIM1	2908	10614	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	HEXIM1 forms a transcriptionally abortive complex with glucocorticoid_receptor without involving 7SK RNA and positive transcription elongation factor b .
16895583	0	glucocorticoid_receptor	30,53	HSP90	54,59	glucocorticoid receptor	HSP90	2908	3320	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|expression expression|compound|END_ENTITY	Region-specific regulation of glucocorticoid_receptor / HSP90 expression and interaction in brain .
15062560	0	glucocorticoid_receptor	35,58	Hsp90	70,75	glucocorticoid receptor	Hsp90	2908	3320	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of nuclear retention of glucocorticoid_receptor by nuclear Hsp90 .
23934279	0	glucocorticoid_receptor	20,43	Importin-7	0,10	glucocorticoid receptor	Importin-7	2908	10527	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Importin-7 mediates glucocorticoid_receptor nuclear import and is impaired by oxidative stress , leading to glucocorticoid insensitivity .
11435608	0	glucocorticoid_receptor	23,46	Interleukin-2	0,13	glucocorticoid receptor	Interleukin-2	2908	3558	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits glucocorticoid_receptor transcriptional activity through a mechanism involving STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- but not AP-1 .
16239257	0	glucocorticoid_receptor	78,101	MED14	0,5	glucocorticoid receptor	MED14	2908	9282	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid_receptor .
10995388	0	glucocorticoid_receptor	4,27	NFkappaB	37,45	glucocorticoid receptor	NFkappaB	2908	4790	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The glucocorticoid_receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain .
15879558	0	glucocorticoid_receptor	4,27	NFkappaB	57,65	glucocorticoid receptor	NFkappaB	2908	4790	Gene	Gene	blocks|nsubj|START_ENTITY blocks|nmod|END_ENTITY	The glucocorticoid_receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression .
12754700	0	glucocorticoid_receptor	24,47	NR3C1	54,59	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variations of the human glucocorticoid_receptor gene -LRB- NR3C1 -RRB- : pathological and in vitro mutations and polymorphisms .
15770078	0	glucocorticoid_receptor	42,65	NR3C1	35,40	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Novel genetic polymorphisms in the NR3C1 -LRB- glucocorticoid_receptor -RRB- gene in a Japanese population .
16216909	0	glucocorticoid_receptor	17,40	NR3C1	42,47	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the glucocorticoid_receptor -LRB- NR3C1 -RRB- gene 5 ' untranslated region : identification , and tissue distribution of multiple new human exon 1 .
16676134	0	glucocorticoid_receptor	24,47	NR3C1	54,59	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variants in the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- and cardiovascular_disease risk .
18536531	0	glucocorticoid_receptor	72,95	NR3C1	102,107	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Prenatal exposure to maternal depression , neonatal methylation of human glucocorticoid_receptor gene -LRB- NR3C1 -RRB- and infant cortisol stress responses .
19133980	0	glucocorticoid_receptor	114,137	NR3C1	144,149	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Glucocorticoid_resistance in a multiple myeloma cell line is regulated by a transcription elongation block in the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- .
19933394	0	glucocorticoid_receptor	172,195	NR3C1	202,207	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Neonatal complete generalized glucocorticoid resistance and growth_hormone_deficiency caused by a novel homozygous mutation in Helix 12 of the ligand binding domain of the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- .
22714792	0	glucocorticoid_receptor	40,63	NR3C1	65,70	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic and epigenetic variation of the glucocorticoid_receptor -LRB- NR3C1 -RRB- in placenta and infant_neurobehavior .
22832351	0	glucocorticoid_receptor	25,48	NR3C1	55,60	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Increased methylation of glucocorticoid_receptor gene -LRB- NR3C1 -RRB- in adults with a history of childhood maltreatment : a link with the severity and type of trauma .
23566423	0	glucocorticoid_receptor	123,146	NR3C1	153,158	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Investigating the influence of maternal cortisol and emotional state during pregnancy on the DNA methylation status of the glucocorticoid_receptor gene -LRB- NR3C1 -RRB- promoter region in cord blood .
27000245	0	glucocorticoid_receptor	33,56	NR3C1	58,63	glucocorticoid receptor	NR3C1	2908	2908	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequencing analysis of the human glucocorticoid_receptor -LRB- NR3C1 -RRB- gene in multiple_sclerosis patients .
19874421	0	glucocorticoid_receptor	49,72	Phosphatidylinositol_3-kinase	0,29	glucocorticoid receptor	Phosphatidylinositol 3-kinase	2908	5295	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase interacts with the glucocorticoid_receptor upon TLR2 activation .
11158330	0	glucocorticoid_receptor	188,211	STAT5	23,28	glucocorticoid receptor	STAT5	2908	6776	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|nmod|END_ENTITY	Cooperative effects of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- and C/EBPbeta -LRB- CCAAT/enhancer-binding _ protein-beta -RRB- on beta-casein gene transcription are mediated by the glucocorticoid_receptor .
12144530	0	glucocorticoid_receptor	64,87	Small_ubiquitin-related_modifier-1	0,34	glucocorticoid receptor	Small ubiquitin-related modifier-1	2908	7341	Gene	Gene	modification|nmod|START_ENTITY END_ENTITY|dep|modification	Small_ubiquitin-related_modifier-1 -LRB- SUMO-1 -RRB- modification of the glucocorticoid_receptor .
15249123	0	glucocorticoid_receptor	20,43	Sp1	66,69	glucocorticoid receptor	Sp1	2908	6667	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of human glucocorticoid_receptor gene transcription by Sp1 and p53 .
17215482	0	glucocorticoid_receptor	14,37	T-bet	72,77	glucocorticoid receptor	T-bet	2908	30009	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The activated glucocorticoid_receptor inhibits the transcription factor T-bet by direct protein-protein interaction .
9787404	0	glucocorticoid_receptor	19,42	TGF_alpha	63,72	glucocorticoid receptor	TGF alpha	2908	7039	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
9787404	0	glucocorticoid_receptor	19,42	TGF_beta_1	74,84	glucocorticoid receptor	TGF beta 1	2908	7040	Gene	Gene	TGF_beta_2|appos|START_ENTITY TGF_beta_2|appos|END_ENTITY	AH receptor , ARNT , glucocorticoid_receptor , EGF_receptor , EGF , TGF_alpha , TGF_beta_1 , TGF_beta_2 , and TGF_beta_3 expression in human embryonic_palate , and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- .
15207724	0	glucocorticoid_receptor	43,66	TIF2	29,33	glucocorticoid receptor	TIF2	2908	10499	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Nuclear structure-associated TIF2 recruits glucocorticoid_receptor and its target DNA .
23132854	0	glucocorticoid_receptor	103,126	TIF2	48,52	glucocorticoid receptor	TIF2	2908	10499	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid_receptor is accompanied by conformational reorganizations .
19284324	0	glucocorticoid_receptor	42,65	VEGF	22,26	glucocorticoid receptor	VEGF	2908	7422	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Fluocinolone inhibits VEGF expression via glucocorticoid_receptor in human retinal pigment epithelial -LRB- ARPE-19 -RRB- cells and TNF-alpha-induced angiogenesis in chick_chorioallantoic_membrane -LRB- CAM -RRB- .
19375531	0	glucocorticoid_receptor	14,37	XAP2	0,4	glucocorticoid receptor	XAP2	2908	9049	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	XAP2 inhibits glucocorticoid_receptor activity in mammalian cells .
11279138	0	glucocorticoid_receptor	24,47	af1/tau1	48,56	glucocorticoid receptor	af1/tau1	2908	3460	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	The conformation of the glucocorticoid_receptor af1/tau1 domain induced by osmolyte binds co-regulatory proteins .
25138562	0	glucocorticoid_receptor	18,41	androgen_receptor	76,93	glucocorticoid receptor	androgen receptor	2908	367	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	The expression of glucocorticoid_receptor is negatively regulated by active androgen_receptor signaling in prostate_tumors .
9873044	0	glucocorticoid_receptor	37,60	beta2-adrenergic_receptor	64,89	glucocorticoid receptor	beta2-adrenergic receptor	2908	154	Gene	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Ligand-independent activation of the glucocorticoid_receptor by beta2-adrenergic_receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells .
16263717	0	glucocorticoid_receptor	141,164	c-Myb	0,5	glucocorticoid receptor	c-Myb	2908	4602	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter mediate|dobj|regulation act|advcl|mediate act|nsubj|END_ENTITY	c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid_receptor 1A promoter .
22516378	0	glucocorticoid_receptor	25,48	c-Myb	0,5	glucocorticoid receptor	c-Myb	2908	4602	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	c-Myb interacts with the glucocorticoid_receptor and regulates its level in pre-B-acute_lymphoblastic_leukemia cells .
24378737	0	glucocorticoid_receptor	14,37	clock	77,82	glucocorticoid receptor	clock	2908	9575	Gene	Gene	properties|compound|START_ENTITY Modulation|nmod|properties Modulation|nmod|proteins proteins|compound|END_ENTITY	Modulation of glucocorticoid_receptor induction properties by core circadian clock proteins .
16644723	0	glucocorticoid_receptor	4,27	cyclin_D1	38,47	glucocorticoid receptor	cyclin D1	2908	595	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	The glucocorticoid_receptor represses cyclin_D1 by targeting the Tcf-beta-catenin complex .
10397722	0	glucocorticoid_receptor	4,27	erythropoietin_receptor	48,71	glucocorticoid receptor	erythropoietin receptor	2908	2057	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The glucocorticoid_receptor cooperates with the erythropoietin_receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro .
23814048	0	glucocorticoid_receptor	15,38	estrogen_receptor	49,66	glucocorticoid receptor	estrogen receptor	2908	2099	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of glucocorticoid_receptor -LRB- GR -RRB- with estrogen_receptor -LRB- ER -RRB- a and activator_protein_1 -LRB- AP1 -RRB- in dexamethasone-mediated interference of ERa activity .
1996114	0	glucocorticoid_receptor	10,33	glucocorticoid_receptor	53,76	glucocorticoid receptor	glucocorticoid receptor	2908	2908	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Decreased glucocorticoid_receptor activity following glucocorticoid_receptor antisense RNA gene fragment transfection .
1996114	0	glucocorticoid_receptor	53,76	glucocorticoid_receptor	10,33	glucocorticoid receptor	glucocorticoid receptor	2908	2908	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Decreased glucocorticoid_receptor activity following glucocorticoid_receptor antisense RNA gene fragment transfection .
22490492	0	glucocorticoid_receptor	91,114	histone_deacetylase_6	18,39	glucocorticoid receptor	histone deacetylase 6	2908	10013	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Nicotine inhibits histone_deacetylase_6 activity and chaperone-dependent activation of the glucocorticoid_receptor in A549 cells .
9353307	0	glucocorticoid_receptor	4,27	hnRNP_U	86,93	glucocorticoid receptor	hnRNP U	2908	3192	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	The glucocorticoid_receptor is associated with the RNA-binding nuclear matrix protein hnRNP_U .
15826950	0	glucocorticoid_receptor	49,72	interleukin-5	14,27	glucocorticoid receptor	interleukin-5	2908	3567	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Repression of interleukin-5 transcription by the glucocorticoid_receptor targets GATA3 signaling and involves histone_deacetylase recruitment .
11162542	0	glucocorticoid_receptor	33,56	nucleolin	18,27	glucocorticoid receptor	nucleolin	2908	4691	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Identification of nucleolin as a glucocorticoid_receptor interacting protein .
11941315	0	glucocorticoid_receptor	45,68	p38	0,3	glucocorticoid receptor	p38	2908	1432	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	p38 Mitogen-activated protein kinase-induced glucocorticoid_receptor phosphorylation reduces its activity : role in steroid-insensitive asthma .
11518712	0	glucocorticoid_receptor	44,67	phosphoenolpyruvate_carboxykinase	75,108	glucocorticoid receptor	phosphoenolpyruvate carboxykinase	2908	5106	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Accessory factors facilitate the binding of glucocorticoid_receptor to the phosphoenolpyruvate_carboxykinase gene promoter .
9426156	0	glucocorticoid_receptor	4,27	prolactin	47,56	glucocorticoid receptor	prolactin	2908	5617	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	The glucocorticoid_receptor inhibits the human prolactin gene expression by interference with Pit-1 activity .
17382897	0	glucocorticoid_receptor	37,60	thioredoxin_reductase_1	10,33	glucocorticoid receptor	thioredoxin reductase 1	2908	7296	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Effect of thioredoxin_reductase_1 on glucocorticoid_receptor activity in human outer root sheath cells .
12379279	0	glucocorticoid_receptor	14,37	transforming_growth_factor-beta	82,113	glucocorticoid receptor	transforming growth factor-beta	2908	7040	Gene	Gene	transactivity|amod|START_ENTITY Antagonism|nmod|transactivity inhibition|nsubj|Antagonism inhibition|nmod|END_ENTITY	Antagonism of glucocorticoid_receptor transactivity and cell growth inhibition by transforming_growth_factor-beta through AP-1-mediated transcriptional repression .
12902338	0	glucocorticoid_receptor	18,41	transforming_growth_factor-beta	81,112	glucocorticoid receptor	transforming growth factor-beta	2908	7040	Gene	Gene	domains|compound|START_ENTITY Identification|nmod|domains involved|nsubj|Identification involved|nmod|transrepression transrepression|nmod|action action|amod|END_ENTITY	Identification of glucocorticoid_receptor domains involved in transrepression of transforming_growth_factor-beta action .
7835313	0	glucocorticoid_receptor	13,36	vasopressin	78,89	glucocorticoid receptor	vasopressin	2908	551	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of glucocorticoid_receptor expression in hypothalamic magnocellular vasopressin neurons during chronic hypoosmolality .
1740341	0	glucokinase	50,61	GCK	68,71	glucokinase	GCK	2645	2645	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A polymorphic -LRB- CA -RRB- n repeat element maps the human glucokinase gene -LRB- GCK -RRB- to chromosome 7p .
18571549	0	glucokinase	74,85	GCK	87,90	glucokinase	GCK	2645	2645	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Permanent_neonatal_diabetes_mellitus caused by a novel homozygous -LRB- T168A -RRB- glucokinase -LRB- GCK -RRB- mutation : initial response to oral sulphonylurea therapy .
24728127	0	glucokinase	32,43	GCK	50,53	glucokinase	GCK	2645	2645	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variation in the glucokinase gene -LRB- GCK -RRB- is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure .
25656763	0	glucokinase	57,68	GCK	70,73	glucokinase	GCK	2645	2645	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pitfalls in the diagnosis of frameshift mutations in the glucokinase -LRB- GCK -RRB- gene and the contribution of an additional cloning sequencing tool .
21454584	0	glucokinase	68,79	Glucagon-like_peptide_1	0,23	glucokinase	Glucagon-like peptide 1	103988(Tax:10090)	14526(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Glucagon-like_peptide_1 stimulates post-translational activation of glucokinase in pancreatic beta cells .
2199215	0	glucokinase	28,39	Interleukin-1_beta	0,18	glucokinase	Interleukin-1 beta	2645	3553	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Interleukin-1_beta inhibits glucokinase activity in clonal HIT-T15 beta-cells .
23139355	0	glucokinase	86,97	MODY2	104,109	glucokinase	MODY2	2645	2645	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene -LRB- MODY2 -RRB- .
17446237	0	glucokinase	21,32	Sp1	0,3	glucokinase	Sp1	2645	6667	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	Sp1 and Sp3 regulate glucokinase gene transcription in the liver of gilthead sea bream -LRB- Sparus aurata -RRB- .
20401447	0	glucokinase	23,34	Urotensin_II	1,13	glucokinase	Urotensin II	24385(Tax:10116)	29180(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	-LSB- Urotensin_II inhibits glucokinase expression and glucose-induced insulin secretion -RSB- .
10588736	0	glucokinase	71,82	glucokinase_regulatory_protein	16,46	glucokinase	glucokinase regulatory protein	103988(Tax:10090)	231103(Tax:10090)	Gene	Gene	decreased|dobj|START_ENTITY decreased|nsubj|mutant mutant|nmod|exhibit exhibit|compound|END_ENTITY	Mice mutant for glucokinase_regulatory_protein exhibit decreased liver glucokinase : a sequestration mechanism in metabolic regulation .
17082186	0	glucokinase	21,32	glucokinase_regulatory_protein	66,96	glucokinase	glucokinase regulatory protein	2645	2646	Gene	Gene	activation|amod|START_ENTITY basis|nmod|activation Biochemical|dobj|basis Biochemical|nmod|END_ENTITY	Biochemical basis of glucokinase activation and the regulation by glucokinase_regulatory_protein in naturally occurring mutations .
18780155	0	glucokinase	72,83	glucokinase_regulatory_protein	8,38	glucokinase	glucokinase regulatory protein	2645	2646	Gene	Gene	activity|compound|START_ENTITY contribute|nmod|activity contribute|nsubj|Lack Lack|nmod|expression expression|compound|END_ENTITY	Lack of glucokinase_regulatory_protein expression may contribute to low glucokinase activity in feline liver .
22716779	0	glucokinase	60,71	glucokinase_regulatory_protein	29,59	glucokinase	glucokinase regulatory protein	2645	2646	Gene	Gene	variation|amod|START_ENTITY associations|dep|variation associations|nmod|END_ENTITY	Relevant associations of the glucokinase_regulatory_protein / glucokinase gene variation with TAG concentrations in a high-cardiovascular risk population : modulation by the Mediterranean_diet .
23957911	0	glucokinase	41,52	glucokinase_regulatory_protein	56,86	glucokinase	glucokinase regulatory protein	2645	2646	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for regulation of human glucokinase by glucokinase_regulatory_protein .
25849650	0	glucokinase	8,19	glucokinase_regulatory_protein	55,85	glucokinase	glucokinase regulatory protein	24385(Tax:10116)	25658(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of glucokinase in the subcellular localization of glucokinase_regulatory_protein .
26620281	0	glucokinase	90,101	glucokinase_regulatory_protein	15,45	glucokinase	glucokinase regulatory protein	103988(Tax:10090)	231103(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY suppressing|dobj|activity decreases|advcl|suppressing decreases|nsubj|Acetylation Acetylation|nmod|END_ENTITY	Acetylation of glucokinase_regulatory_protein decreases glucose metabolism by suppressing glucokinase activity .
11950391	0	glucokinase	14,25	hepatic_nuclear_factor_4alpha	45,74	glucokinase	hepatic nuclear factor 4alpha	24385(Tax:10116)	25735(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of glucokinase gene expression by hepatic_nuclear_factor_4alpha in primary hepatocytes .
14749268	0	glucokinase	6,17	peroxisome_proliferator-activated_receptor-gamma	38,86	glucokinase	peroxisome proliferator-activated receptor-gamma	24385(Tax:10116)	25664(Tax:10116)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Liver glucokinase can be activated by peroxisome_proliferator-activated_receptor-gamma .
22105854	0	glucokinase_regulatory_protein	15,45	GCKR	47,51	glucokinase regulatory protein	GCKR	2646	2646	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variant in the glucokinase_regulatory_protein -LRB- GCKR -RRB- gene is associated with fatty_liver in obese children and adolescents .
10588736	0	glucokinase_regulatory_protein	16,46	glucokinase	71,82	glucokinase regulatory protein	glucokinase	231103(Tax:10090)	103988(Tax:10090)	Gene	Gene	exhibit|compound|START_ENTITY mutant|nmod|exhibit decreased|nsubj|mutant decreased|dobj|END_ENTITY	Mice mutant for glucokinase_regulatory_protein exhibit decreased liver glucokinase : a sequestration mechanism in metabolic regulation .
17082186	0	glucokinase_regulatory_protein	66,96	glucokinase	21,32	glucokinase regulatory protein	glucokinase	2646	2645	Gene	Gene	Biochemical|nmod|START_ENTITY Biochemical|dobj|basis basis|nmod|activation activation|amod|END_ENTITY	Biochemical basis of glucokinase activation and the regulation by glucokinase_regulatory_protein in naturally occurring mutations .
18780155	0	glucokinase_regulatory_protein	8,38	glucokinase	72,83	glucokinase regulatory protein	glucokinase	2646	2645	Gene	Gene	expression|compound|START_ENTITY Lack|nmod|expression contribute|nsubj|Lack contribute|nmod|activity activity|compound|END_ENTITY	Lack of glucokinase_regulatory_protein expression may contribute to low glucokinase activity in feline liver .
22716779	0	glucokinase_regulatory_protein	29,59	glucokinase	60,71	glucokinase regulatory protein	glucokinase	2646	2645	Gene	Gene	associations|nmod|START_ENTITY associations|dep|variation variation|amod|END_ENTITY	Relevant associations of the glucokinase_regulatory_protein / glucokinase gene variation with TAG concentrations in a high-cardiovascular risk population : modulation by the Mediterranean_diet .
23957911	0	glucokinase_regulatory_protein	56,86	glucokinase	41,52	glucokinase regulatory protein	glucokinase	2646	2645	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for regulation of human glucokinase by glucokinase_regulatory_protein .
25849650	0	glucokinase_regulatory_protein	55,85	glucokinase	8,19	glucokinase regulatory protein	glucokinase	25658(Tax:10116)	24385(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of glucokinase in the subcellular localization of glucokinase_regulatory_protein .
26620281	0	glucokinase_regulatory_protein	15,45	glucokinase	90,101	glucokinase regulatory protein	glucokinase	231103(Tax:10090)	103988(Tax:10090)	Gene	Gene	Acetylation|nmod|START_ENTITY decreases|nsubj|Acetylation decreases|advcl|suppressing suppressing|dobj|activity activity|amod|END_ENTITY	Acetylation of glucokinase_regulatory_protein decreases glucose metabolism by suppressing glucokinase activity .
16585534	0	gluconolactonase	42,58	Senescence_marker_protein_30	0,28	gluconolactonase	Senescence marker protein 30	19733(Tax:10090)	19733(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Senescence_marker_protein_30 functions as gluconolactonase in L-ascorbic_acid biosynthesis , and its knockout mice are prone to scurvy .
17543346	0	glucose	26,33	insulin	15,22	insulin	insulin	3630	3630	Gene	Gene	transport|compound|START_ENTITY effects|nmod|transport effects|nmod|END_ENTITY	The effects of insulin on glucose and fluid transport in the isolated small intestine of normal rats .
11467835	0	glucose-6-phosphatase	38,59	FKHR	151,155	glucose-6-phosphatase	FKHR	25634(Tax:10116)	84482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of endogenous glucose-6-phosphatase and phosphoenolpyruvate_carboxykinase gene expression by the forkhead transcription factor FKHR in H4IIE-hepatoma cells .
12507516	0	glucose-6-phosphatase	51,72	FKHR	27,31	glucose-6-phosphatase	FKHR	25634(Tax:10116)	84482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	DYRK1 is a co-activator of FKHR -LRB- FOXO1a -RRB- - dependent glucose-6-phosphatase gene expression .
12546415	0	glucose-6-phosphatase	14,35	G6Pase	37,43	glucose-6-phosphatase	G6Pase	25634(Tax:10116)	25634(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Thielavins as glucose-6-phosphatase -LRB- G6Pase -RRB- inhibitors : producing strain , fermentation , isolation , structural elucidation and biological activities .
9369482	0	glucose-6-phosphatase	52,73	HNF1alpha	12,21	glucose-6-phosphatase	HNF1alpha	2538	6927	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	The role of HNF1alpha , HNF3gamma , and cyclic_AMP in glucose-6-phosphatase gene activation .
9169094	0	glucose-6-phosphatase	48,69	Insulin	0,7	glucose-6-phosphatase	Insulin	403492(Tax:9615)	483665(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Insulin resistance and the transcription of the glucose-6-phosphatase gene in newborn dogs .
2827496	0	glucose-6-phosphatase	17,38	catalase	55,63	glucose-6-phosphatase	catalase	25634(Tax:10116)	24248(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Demonstration of glucose-6-phosphatase and peroxisomal catalase activity by ultrastructural cytochemistry in oval cells from livers of carcinogen-treated rats .
25288127	0	glucose-6-phosphatase	51,72	glucose-6-phosphate_transporter	73,104	glucose-6-phosphatase	glucose-6-phosphate transporter	2538	2538	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Type I glycogen storage diseases : disorders of the glucose-6-phosphatase / glucose-6-phosphate_transporter complexes .
19579180	0	glucose-6-phosphatase	14,35	insulin	55,62	glucose-6-phosphatase	insulin	2538	3630	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of glucose-6-phosphatase gene expression by insulin and metformin .
9685358	0	glucose-6-phosphatase	69,90	insulin	113,120	glucose-6-phosphatase	insulin	2538	3630	Gene	Gene	gene|amod|START_ENTITY repression|nmod|gene 3-kinase|nmod|repression role|nmod|3-kinase transcription|nsubj|role transcription|nmod|END_ENTITY	Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin .
18449899	0	glucose-6-phosphatase-alpha	17,44	G6PC	46,50	glucose-6-phosphatase-alpha	G6PC	2538	2538	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the glucose-6-phosphatase-alpha -LRB- G6PC -RRB- gene that cause type Ia glycogen storage disease .
25632835	0	glucose-6-phosphate_dehydrogenase	19,52	G-6-PD	54,60	glucose-6-phosphate dehydrogenase	G-6-PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Relationship among glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity , G-6-PD variants and reticulocytosis in neonates of northeast Thailand .
25632835	0	glucose-6-phosphate_dehydrogenase	19,52	G-6-PD	72,78	glucose-6-phosphate dehydrogenase	G-6-PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Relationship among glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity , G-6-PD variants and reticulocytosis in neonates of northeast Thailand .
3083896	0	glucose-6-phosphate_dehydrogenase	16,49	G-6-PD	51,57	glucose-6-phosphate dehydrogenase	G-6-PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Low erythrocyte glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity and susceptibility to carbaryl-induced methemoglobin formation and glutathione depletion .
4095209	0	glucose-6-phosphate_dehydrogenase	10,43	G-6-PD	45,51	glucose-6-phosphate dehydrogenase	G-6-PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Leucocyte glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- activity in G-6-PD deficient Chinese .
10709108	0	glucose-6-phosphate_dehydrogenase	6,39	G6PD	41,45	glucose-6-phosphate dehydrogenase	G6PD	14380(Tax:10090)	14380(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Human glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- gene transforms NIH 3T3 cells and induces tumors in nude_mice .
10869567	0	glucose-6-phosphate_dehydrogenase	9,42	G6PD	44,48	glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	status|amod|START_ENTITY status|compound|END_ENTITY	Cellular glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- status modulates the effects of nitric_oxide -LRB- NO -RRB- on human foreskin fibroblasts .
1562739	0	glucose-6-phosphate_dehydrogenase	34,67	G6PD	69,73	glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Diverse point mutations result in glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- polymorphism in Taiwan .
4405142	0	glucose-6-phosphate_dehydrogenase	29,62	G6PD	73,77	glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of 17-ketosteroids on glucose-6-phosphate_dehydrogenase activity -LRB- G6PD -RRB- and on G6PD isoenzymes .
6431656	0	glucose-6-phosphate_dehydrogenase	26,59	G6PD	61,65	glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Depression of erythrocyte glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- activity in enteric_fever .
7607684	0	glucose-6-phosphate_dehydrogenase	52,85	G6PD	92,96	glucose-6-phosphate dehydrogenase	G6PD	101071498	101071498	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and sequence of the Fugu_rubripes glucose-6-phosphate_dehydrogenase gene -LRB- G6PD -RRB- .
8333738	0	glucose-6-phosphate_dehydrogenase	9,42	G6PD	44,48	glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	Study|nmod|START_ENTITY Study|appos|END_ENTITY	Study of glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- in the Kissan tribals of Orissa and the Kannikar tribals of Kerala , India .
9332310	0	glucose-6-phosphate_dehydrogenase	25,58	G6PD	60,64	glucose-6-phosphate dehydrogenase	G6PD	2539	2539	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two new mutations of the glucose-6-phosphate_dehydrogenase -LRB- G6PD -RRB- gene associated with haemolytic_anaemia : clinical , biochemical and molecular relationships .
10996244	0	glucose-6-phosphate_dehydrogenase	23,56	G6PDH	58,63	glucose-6-phosphate dehydrogenase	G6PDH	542778(Tax:4565)	542778(Tax:4565)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Specific expression of glucose-6-phosphate_dehydrogenase -LRB- G6PDH -RRB- gene by salt stress in wheat -LRB- Triticum_aestivum_L . -RRB- .
21870182	0	glucose-6-phosphate_dehydrogenase	61,94	G6PDH	96,101	glucose-6-phosphate dehydrogenase	G6PDH	2539	2539	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Prediction of oocyte developmental competence in ovine using glucose-6-phosphate_dehydrogenase -LRB- G6PDH -RRB- activity determined at retrieval time .
22307442	0	glucose-6-phosphate_dehydrogenase	44,77	GLA	8,11	glucose-6-phosphate dehydrogenase	GLA	2539	2717	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	A novel GLA mutation in a Fabry family with glucose-6-phosphate_dehydrogenase deficiency .
809968	0	glucose-6-phosphate_dehydrogenase	79,112	Haptoglobin	0,11	glucose-6-phosphate dehydrogenase	Haptoglobin	2539	3240	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Haptoglobin , hemopexin , hemoglobin and hematocrit in newborns with erythrocyte glucose-6-phosphate_dehydrogenase deficiency .
15956780	0	glucose-6-phosphate_dehydrogenase	30,63	PKA	82,85	glucose-6-phosphate dehydrogenase	PKA	24377(Tax:10116)	25636(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Diabetes causes inhibition of glucose-6-phosphate_dehydrogenase via activation of PKA , which contributes to oxidative stress in rat kidney cortex .
15054810	0	glucose-6-phosphate_dehydrogenase	76,109	bisphosphoglycerate_mutase	22,48	glucose-6-phosphate dehydrogenase	bisphosphoglycerate mutase	2539	669	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Erythrocytosis due to bisphosphoglycerate_mutase deficiency with concurrent glucose-6-phosphate_dehydrogenase -LRB- G-6-PD -RRB- deficiency .
9330624	0	glucose-6-phosphate_dehydrogenase	24,57	g6pd	59,63	glucose-6-phosphate dehydrogenase	g6pd	14380(Tax:10090)	14380(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Somatic mutation of the glucose-6-phosphate_dehydrogenase -LRB- g6pd -RRB- gene in colonic stem cells and crypt restricted loss of G6PD activity .
2867080	0	glucose-6-phosphate_dehydrogenase	66,99	glutathione_S-transferase	35,60	glucose-6-phosphate dehydrogenase	glutathione S-transferase	24377(Tax:10116)	58962(Tax:10116)	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the various forms of glutathione_S-transferase with glucose-6-phosphate_dehydrogenase and gamma-glutamyltranspeptidase as markers of preneoplastic and neoplastic_lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine .
2768849	0	glucose-6-phosphate_dehydrogenase	83,116	oasis	72,77	glucose-6-phosphate dehydrogenase	oasis	2539	90993	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	An investigation into the riboflavin status of young Egyptians from the oasis with glucose-6-phosphate_dehydrogenase deficiency .
16210322	0	glucose-6-phosphate_dehydrogenase	51,84	p38	89,92	glucose-6-phosphate dehydrogenase	p38	2539	1432	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Arachidonic_acid inhibits the insulin induction of glucose-6-phosphate_dehydrogenase via p38 MAP kinase .
25288127	0	glucose-6-phosphate_transporter	73,104	glucose-6-phosphatase	51,72	glucose-6-phosphate transporter	glucose-6-phosphatase	2538	2538	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Type I glycogen storage diseases : disorders of the glucose-6-phosphatase / glucose-6-phosphate_transporter complexes .
10738525	0	glucose-6_phosphatase	56,77	G6PC	79,83	glucose-6 phosphatase	G6PC	2538	2538	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Enzymatic characterization of four new mutations in the glucose-6_phosphatase -LRB- G6PC -RRB- gene which cause glycogen_storage_disease_type_1a .
15486225	0	glucose-dependent-insulinotropic_polypeptide	28,72	PDX-1	114,119	glucose-dependent-insulinotropic polypeptide	PDX-1	14607(Tax:10090)	18609(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Cell-specific expression of glucose-dependent-insulinotropic_polypeptide is regulated by the transcription factor PDX-1 .
25091498	0	glucose-dependent_insulinotropic_peptide	15,55	Insulin	0,7	glucose-dependent insulinotropic peptide	Insulin	2695	3630	Gene	Gene	expression|amod|START_ENTITY drives|dobj|expression drives|nsubj|END_ENTITY	Insulin drives glucose-dependent_insulinotropic_peptide expression via glucose-dependent regulation of FoxO1 and LEF1/b-catenin .
7705803	0	glucose-dependent_insulinotropic_peptide	39,79	Insulin	0,7	glucose-dependent insulinotropic peptide	Insulin	2695	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Insulin secretion and plasma levels of glucose-dependent_insulinotropic_peptide and glucagon-like_peptide_1 -LSB- 7-36 amide -RSB- after oral glucose in cirrhosis .
12686473	0	glucose-dependent_insulinotropic_polypeptide	32,76	GATA	102,106	glucose-dependent insulinotropic polypeptide	GATA	14607(Tax:10090)	76563(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Cell-specific expression of the glucose-dependent_insulinotropic_polypeptide gene functions through a GATA and an ISL-1 motif in a mouse neuroendocrine_tumor cell line .
18343025	0	glucose-dependent_insulinotropic_polypeptide	19,63	GATA-4	0,6	glucose-dependent insulinotropic polypeptide	GATA-4	14607(Tax:10090)	14463(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	GATA-4 upregulates glucose-dependent_insulinotropic_polypeptide expression in cells of pancreatic and intestinal lineage .
11323439	0	glucose-dependent_insulinotropic_polypeptide	18,62	GIP	64,67	glucose-dependent insulinotropic polypeptide	GIP	100753817	100753817	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A new pathway for glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- receptor signaling : evidence for the involvement of phospholipase_A2 in GIP-stimulated insulin secretion .
16913844	0	glucose-dependent_insulinotropic_polypeptide	21,65	GIP	67,70	glucose-dependent insulinotropic polypeptide	GIP	14607(Tax:10090)	14607(Tax:10090)	Gene	Gene	analogue|nmod|START_ENTITY analogue|appos|END_ENTITY	A stable analogue of glucose-dependent_insulinotropic_polypeptide , GIP -LRB- LysPAL16 -RRB- , enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones .
20483270	0	glucose-dependent_insulinotropic_polypeptide	28,72	GIP	74,77	glucose-dependent insulinotropic polypeptide	GIP	2695	2695	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evolution of the vertebrate glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- gene .
20621665	0	glucose-dependent_insulinotropic_polypeptide	29,73	GIP	75,78	glucose-dependent insulinotropic polypeptide	GIP	2695	2695	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evolutionary conservation of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- gene regulation and the enteroinsular axis .
21146561	0	glucose-dependent_insulinotropic_polypeptide	15,59	GIP	61,64	glucose-dependent insulinotropic polypeptide	GIP	25040(Tax:10116)	25040(Tax:10116)	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- during cold acclimation .
8188305	0	glucose-dependent_insulinotropic_polypeptide	16,60	GIP	62,65	glucose-dependent insulinotropic polypeptide	GIP	2695	2695	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- to a gene cluster on chromosome 17q .
9279024	0	glucose-dependent_insulinotropic_polypeptide	10,54	GIP	56,59	glucose-dependent insulinotropic polypeptide	GIP	2695	2695	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- on insulin response to glucose in acromegalics .
9820111	0	glucose-dependent_insulinotropic_polypeptide	26,70	GIP	72,75	glucose-dependent insulinotropic polypeptide	GIP	2695	2695	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Clinical significance of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- -RSB- .
17244606	0	glucose-dependent_insulinotropic_polypeptide	36,80	lipoprotein_lipase	14,32	glucose-dependent insulinotropic polypeptide	lipoprotein lipase	2695	4023	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of lipoprotein_lipase by glucose-dependent_insulinotropic_polypeptide in adipocytes .
17890220	0	glucose-dependent_insulinotropic_polypeptide	30,74	lipoprotein_lipase	96,114	glucose-dependent insulinotropic polypeptide	lipoprotein lipase	25040(Tax:10116)	24539(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Resistin is a key mediator of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- stimulation of lipoprotein_lipase -LRB- LPL -RRB- activity in adipocytes .
23002036	0	glucose-dependent_insulinotropic_polypeptide_receptor	50,103	GIPR	105,109	glucose-dependent insulinotropic polypeptide receptor	GIPR	381853(Tax:10090)	381853(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Resistin knockout mice exhibit impaired adipocyte glucose-dependent_insulinotropic_polypeptide_receptor -LRB- GIPR -RRB- expression .
15111246	0	glucose-regulated_protein	19,44	GRP78	46,51	glucose-regulated protein	GRP78	25617(Tax:10116)	25617(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of 78 kD glucose-regulated_protein -LRB- GRP78 -RRB- expression and redox-regulated transcription factor activity by lead and mercury in C6 rat glioma cells .
23280503	0	glucose-regulated_protein	32,57	GRP78	25,30	glucose-regulated protein	GRP78	3309	3309	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	AKT inhibition mitigates GRP78 -LRB- glucose-regulated_protein -RRB- expression and contribution to chemoresistance in endometrial_cancers .
8863896	0	glucose-regulated_protein	22,47	grp78	49,54	glucose-regulated protein	grp78	25617(Tax:10116)	25617(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes of the 78 kDa glucose-regulated_protein -LRB- grp78 -RRB- in livers of diabetic rats .
27016417	0	glucose-regulated_protein_78	98,126	GRP78	128,133	glucose-regulated protein 78	GRP78	3309	3309	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cancer-associated fibroblasts promote non-small_cell_lung_cancer cell invasion by upregulation of glucose-regulated_protein_78 -LRB- GRP78 -RRB- expression in an integrated bionic microfluidic device .
16036795	0	glucose-related_protein_78	94,120	cyclooxygenase-2	27,43	glucose-related protein 78	cyclooxygenase-2	3309	19225(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Up-regulation of astrocyte cyclooxygenase-2 , CCAAT/enhancer-binding _ protein-homology protein , glucose-related_protein_78 , eukaryotic initiation factor 2 alpha , and c-Jun N-terminal kinase by a neurovirulent murine retrovirus .
23252580	0	glucose_6-phosphate_dehydrogenase	35,68	lysozyme	25,33	glucose 6-phosphate dehydrogenase	lysozyme	281179(Tax:9913)	781146(Tax:9913)	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Chemical modification of lysozyme , glucose_6-phosphate_dehydrogenase , _ and_bovine_eye_lens_proteins induced by peroxyl radicals : role of oxidizable amino_acid residues .
15645696	0	glucose_dependent_insulinotropic_peptide	17,57	Cholecystokinin	0,15	glucose dependent insulinotropic peptide	Cholecystokinin	2695	885	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|appos|secretion	Cholecystokinin , glucose_dependent_insulinotropic_peptide and glucagon-like_peptide_1 secretion in children with anorexia_nervosa and simple_obesity .
18792902	0	glucose_oxidase	47,62	GOx	64,67	glucose oxidase	GOx	54363	54363	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	A new route to the considerable enhancement of glucose_oxidase -LRB- GOx -RRB- activity : the simple assembly of a complex from CdTe quantum dots and GOx , and its glucose sensing .
11687283	0	glucose_regulated_protein	31,56	GRP78	61,66	glucose regulated protein	GRP78	25617(Tax:10116)	25617(Tax:10116)	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	Hypothermic treatment restores glucose_regulated_protein 78 -LRB- GRP78 -RRB- expression in ischemic brain .
9595551	0	glucose_regulated_protein	39,64	GRP_78	66,72	glucose regulated protein	GRP 78	3309	3309	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cell surface localization of the 78 kD glucose_regulated_protein -LRB- GRP_78 -RRB- induced by thapsigargin .
8897851	0	glucose_transport	48,65	GLUT-4	67,73	glucose transport	GLUT-4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	In vivo effects of dexamethasone and sucrose on glucose_transport -LRB- GLUT-4 -RRB- protein tissue distribution .
11304809	0	glucose_transport_protein	37,62	Glut3	64,69	glucose transport protein	Glut3	25551(Tax:10116)	25551(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Quantitative immunohistochemistry of glucose_transport_protein -LRB- Glut3 -RRB- expression in the rat hippocampus during aging .
10622535	0	glucose_transporter	40,59	GLUT	61,65	glucose transporter	GLUT	6513	6513	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Differential expression of facilitative glucose_transporter -LRB- GLUT -RRB- genes in primary lung_cancers and their liver metastases .
15389572	0	glucose_transporter	37,56	GLUT	58,62	glucose transporter	GLUT	6513	6513	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Molecular and cellular regulation of glucose_transporter -LRB- GLUT -RRB- proteins in cancer .
8646755	0	glucose_transporter	28,47	GLUT-1	49,55	glucose transporter	GLUT-1	6513	24778(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Subcellular distribution of glucose_transporter -LRB- GLUT-1 -RRB- during development of the blood-brain barrier in rats .
9486290	0	glucose_transporter	70,89	GLUT-1	91,97	glucose transporter	GLUT-1	24778(Tax:10116)	24778(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Time-dependent physiological regulation of rodent and ovine placental glucose_transporter -LRB- GLUT-1 -RRB- protein .
11231353	0	glucose_transporter	21,40	GLUT1	42,47	glucose transporter	GLUT1	6513	6513	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the glucose_transporter -LRB- GLUT1 -RRB- gene are associated with diabetic_nephropathy .
16639702	0	glucose_transporter	18,37	GLUT1	39,44	glucose transporter	GLUT1	20525(Tax:10090)	20525(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	The regulation of glucose_transporter -LRB- GLUT1 -RRB- expression by the RNA binding protein HuR .
8995440	0	glucose_transporter	42,61	GLUT1	63,68	glucose transporter	GLUT1	6513	6513	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Tumor_necrosis_factor-alpha regulation of glucose_transporter -LRB- GLUT1 -RRB- mRNA turnover .
9001249	0	glucose_transporter	64,83	GLUT1	85,90	glucose transporter	GLUT1	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ectopic expression of Hel-N1 , an RNA-binding protein , increases glucose_transporter -LRB- GLUT1 -RRB- expression in 3T3-L1 adipocytes .
7593414	0	glucose_transporter	50,69	GLUT2	71,76	glucose transporter	GLUT2	6514	6514	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence variations of the pancreatic islet/liver glucose_transporter -LRB- GLUT2 -RRB- gene in Japanese subjects with noninsulin dependent diabetes_mellitus .
17575039	0	glucose_transporter	28,47	GLUT4	49,54	glucose transporter	GLUT4	6517	6517	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Physiological regulation of glucose_transporter -LRB- GLUT4 -RRB- protein content in brown trout -LRB- Salmo trutta -RRB- skeletal muscle .
19549745	0	glucose_transporter	36,55	GLUT4	84,89	glucose transporter	GLUT4	6513	6517	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Insulin-stimulated translocation of glucose_transporter -LRB- GLUT -RRB- 12 parallels that of GLUT4 in normal muscle .
7738859	0	glucose_transporter	29,48	GLUT4	49,54	glucose transporter	GLUT4	6517	6517	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Eccentric exercise decreases glucose_transporter GLUT4 protein in human skeletal muscle .
8224371	0	glucose_transporter	104,123	GLUT4	125,130	glucose transporter	GLUT4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose_transporter -LRB- GLUT4 -RRB- protein .
8276864	0	glucose_transporter	54,73	GLUT4	80,85	glucose transporter	GLUT4	6517	6517	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Arachidonic_acid down-regulates the insulin-dependent glucose_transporter gene -LRB- GLUT4 -RRB- in 3T3-L1 adipocytes by inhibiting transcription and enhancing mRNA turnover .
9301415	0	glucose_transporter	27,46	GLUT4	48,53	glucose transporter	GLUT4	282359(Tax:9913)	282359(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Weaning marginally affects glucose_transporter -LRB- GLUT4 -RRB- expression in calf muscles and adipose tissues .
7820675	0	glucose_transporter	45,64	GLUT_1	66,72	glucose transporter	GLUT 1	6513	6513	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Immunocytochemical distribution of the brain glucose_transporter -LRB- GLUT_1 -RRB- in experimental gliosis .
11906177	0	glucose_transporter	45,64	GLUT_4	66,72	glucose transporter	GLUT 4	20528(Tax:10090)	20528(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Exercise-induced transcription of the muscle glucose_transporter -LRB- GLUT_4 -RRB- gene .
1324860	0	glucose_transporter	53,72	GLUT_4	74,80	glucose transporter	GLUT 4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Normal insulin_receptor tyrosine kinase activity and glucose_transporter -LRB- GLUT_4 -RRB- levels in the skeletal muscle of hyperinsulinaemic hypertensive rats .
12529975	0	glucose_transporter	7,26	Glut-1	0,6	glucose transporter	Glut-1	6513	6513	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Glut-1 glucose_transporter expression in esophageal_squamous_cell_carcinoma is associated with tumor_aggressiveness .
2100513	0	glucose_transporter	19,38	Glut-1	40,46	glucose transporter	Glut-1	20525(Tax:10090)	20525(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vanadate regulates glucose_transporter -LRB- Glut-1 -RRB- expression in NIH3T3 mouse fibroblasts .
10441390	0	glucose_transporter	20,39	Glut1	14,19	glucose transporter	Glut1	24778(Tax:10116)	24778(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of Glut1 glucose_transporter in response to inhibition of oxidative phosphorylation .
1581603	0	glucose_transporter	11,30	Glut_1	32,38	glucose transporter	Glut 1	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pattern of glucose_transporter -LRB- Glut_1 -RRB- expression in embryonic brains is related to maturation of blood-brain barrier tightness .
16639702	0	glucose_transporter	18,37	HuR	84,87	glucose transporter	HuR	20525(Tax:10090)	15568(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY expression|nsubj|regulation expression|nmod|END_ENTITY	The regulation of glucose_transporter -LRB- GLUT1 -RRB- expression by the RNA binding protein HuR .
8995440	0	glucose_transporter	42,61	Tumor_necrosis_factor-alpha	0,27	glucose transporter	Tumor necrosis factor-alpha	6513	7124	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Tumor_necrosis_factor-alpha regulation of glucose_transporter -LRB- GLUT1 -RRB- mRNA turnover .
18410529	0	glucose_transporter-1	38,59	GLUT-1	61,67	glucose transporter-1	GLUT-1	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Resistin modulates glucose uptake and glucose_transporter-1 -LRB- GLUT-1 -RRB- expression in trophoblast cells .
15924676	0	glucose_transporter-1	15,36	basic_fibroblast_growth_factor	62,92	glucose transporter-1	basic fibroblast growth factor	6513	2247	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of glucose_transporter-1 and its correlation with basic_fibroblast_growth_factor and proliferating_cell_nuclear_antigen in epithelial_ovarian_neoplasm -RSB- .
11715528	0	glucose_transporter-1	67,88	transforming_growth_factor-beta	22,53	glucose transporter-1	transforming growth factor-beta	6513	7040	Gene	Gene	-RSB-|amod|START_ENTITY effect|nmod|-RSB- effect|nmod|END_ENTITY	-LSB- Modulatory effect of transforming_growth_factor-beta and Rhein on glucose_transporter-1 in human glomerular mesangial cells -RSB- .
10736070	0	glucose_transporter-1_protein	25,54	GLUT-1	56,62	glucose transporter-1 protein	GLUT-1	6513	6513	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Membranous expression of glucose_transporter-1_protein -LRB- GLUT-1 -RRB- in embryonal_neoplasms of the central nervous system .
23054751	0	glucose_transporter-3	24,45	GLUT-3	47,53	glucose transporter-3	GLUT-3	6515	6515	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Progressive increase of glucose_transporter-3 -LRB- GLUT-3 -RRB- expression in estrogen-induced breast_carcinogenesis .
24906930	0	glucose_transporter-4	17,38	GLUT4	40,45	glucose transporter-4	GLUT4	282359(Tax:9913)	282359(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Myostatin alters glucose_transporter-4 -LRB- GLUT4 -RRB- expression in bovine skeletal muscles and myoblasts isolated from double-muscled -LRB- DM -RRB- and normal-muscled -LRB- NM -RRB- Japanese shorthorn cattle .
24906930	0	glucose_transporter-4	17,38	Myostatin	0,9	glucose transporter-4	Myostatin	282359(Tax:9913)	281187(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY alters|dobj|expression alters|nsubj|END_ENTITY	Myostatin alters glucose_transporter-4 -LRB- GLUT4 -RRB- expression in bovine skeletal muscles and myoblasts isolated from double-muscled -LRB- DM -RRB- and normal-muscled -LRB- NM -RRB- Japanese shorthorn cattle .
11972644	0	glucose_transporter_1	140,161	GLUT-1	163,169	glucose transporter 1	GLUT-1	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Significance of 18F-fluorodeoxyglucose positron emission tomography -LRB- FDG-PET -RRB- for detection of renal_cell_carcinoma and immunohistochemical glucose_transporter_1 -LRB- GLUT-1 -RRB- expression in the cancer .
12417042	0	glucose_transporter_1	25,46	GLUT1	48,53	glucose transporter 1	GLUT1	6513	6513	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical significance of glucose_transporter_1 -LRB- GLUT1 -RRB- expression in human breast_carcinoma .
8755650	2	glucose_transporter_1	47,68	GLUT1	70,75	glucose transporter 1	GLUT1	397404(Tax:9823)	397404(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Activation of the glucose_transporter_1 -LRB- GLUT1 -RRB- gene and glycolysis in LLC-PK1 cells under Ca2 + stress .
25492937	0	glucose_transporter_1	49,70	Glut1	42,47	glucose transporter 1	Glut1	6513	6513	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Foxp3-mediated inhibition of Akt inhibits Glut1 -LRB- glucose_transporter_1 -RRB- expression in human T regulatory cells .
12010641	0	glucose_transporter_1	69,90	basic_fibroblast_growth_factor	134,164	glucose transporter 1	basic fibroblast growth factor	24778(Tax:10116)	54250(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Regulation of lactate production and glucose transport as well as of glucose_transporter_1 and lactate_dehydrogenase_A mRNA levels by basic_fibroblast_growth_factor in rat Sertoli cells .
15525582	0	glucose_transporter_1	13,34	hypoxia-inducible_factor_1alpha	54,85	glucose transporter 1	hypoxia-inducible factor 1alpha	6513	3091	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of glucose_transporter_1 expression through hypoxia-inducible_factor_1alpha under hypoxic conditions in trophoblast-derived cells .
15482900	0	glucose_transporter_2	39,60	GLUT2	62,67	glucose transporter 2	GLUT2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of the glucose_transporter_2 -LRB- GLUT2 -RRB- in the adult rat brain .
15665515	0	glucose_transporter_2	26,47	GLUT2	49,54	glucose transporter 2	GLUT2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Insulin_receptor _ -LRB- IR -RRB- and glucose_transporter_2 -LRB- GLUT2 -RRB- proteins form a complex on the rat hepatocyte membrane .
9665105	0	glucose_transporter_2	92,113	GLUT2	115,120	glucose transporter 2	GLUT2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Short-chain fatty_acid-supplemented total parenteral nutrition alters intestinal structure , glucose_transporter_2 -LRB- GLUT2 -RRB- mRNA and protein , and proglucagon mRNA abundance in normal rats .
7744215	0	glucose_transporter_2	85,106	GLUT_2	108,114	glucose transporter 2	GLUT 2	6514	6514	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional analysis of DNA-elements involved in transcriptional control of the human glucose_transporter_2 -LRB- GLUT_2 -RRB- gene in the insulin-producing cell line beta_TC-3 .
23341039	0	glucose_transporter_3	42,63	CREB	0,4	glucose transporter 3	CREB	6515	1385	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CREB regulates the expression of neuronal glucose_transporter_3 : a possible mechanism related to impaired brain glucose uptake in Alzheimer 's _ disease .
22079207	0	glucose_transporter_4	73,94	GLUT4	96,101	glucose transporter 4	GLUT4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Protein restriction during gestation alters histone modifications at the glucose_transporter_4 -LRB- GLUT4 -RRB- promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring .
23074218	0	glucose_transporter_4	23,44	GLUT4	46,51	glucose transporter 4	GLUT4	6517	6517	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Vitamin_D up-regulates glucose_transporter_4 -LRB- GLUT4 -RRB- translocation and glucose utilization mediated by cystathionine-y-lyase -LRB- CSE -RRB- activation and H2S formation in 3T3L1 adipocytes .
23135276	0	glucose_transporter_4	20,41	GLUT4	43,48	glucose transporter 4	GLUT4	20528(Tax:10090)	20528(Tax:10090)	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Metformin regulates glucose_transporter_4 -LRB- GLUT4 -RRB- translocation through AMP-activated protein kinase -LRB- AMPK -RRB- - mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells .
15013641	0	glucose_transporter_8	20,41	GLUT8	43,48	glucose transporter 8	GLUT8	282867(Tax:9913)	282867(Tax:9913)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of glucose_transporter_8 -LRB- GLUT8 -RRB- in the ovine placenta of normal and growth restricted fetuses .
22971798	0	glucose_transporter_protein-1	14,43	hypoxia_inducible_factor_1a	86,113	glucose transporter protein-1	hypoxia inducible factor 1a	6513	3091	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of glucose_transporter_protein-1 and vascular_endothelial_growth_factor by hypoxia_inducible_factor_1a under hypoxic conditions in Hep-2 human cells .
10740976	0	glucose_transporter_type_1	71,97	GLUT1	99,104	glucose transporter type 1	GLUT1	100753506	100753506	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose_transporter_type_1 -LRB- GLUT1 -RRB- translocation in Chinese_hamster_ovary -LRB- CHO -RRB- cells stably expressing fMLP or PAF receptor .
8674846	0	glucose_transporter_type_2	34,60	GLUT2	62,67	glucose transporter type 2	GLUT2	20526(Tax:10090)	20526(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	A 338-bp proximal fragment of the glucose_transporter_type_2 -LRB- GLUT2 -RRB- promoter drives reporter gene expression in the pancreatic islets of transgenic_mice .
9312184	0	glucose_transporter_type_4	87,113	GLUT4	115,120	glucose transporter type 4	GLUT4	20528(Tax:10090)	20528(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose_transporter_type_4 -LRB- GLUT4 -RRB- gene .
26770384	0	glucose_transporter_type_4	68,94	retinol-binding_protein_4	26,51	glucose transporter type 4	retinol-binding protein 4	25139(Tax:10116)	25703(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Sitagliptin downregulates retinol-binding_protein_4 and upregulates glucose_transporter_type_4 expression in a type_2_diabetes_mellitus rat model .
23555901	0	glucosylceramide_synthase	46,71	ARF6	0,4	glucosylceramide synthase	ARF6	22234(Tax:10090)	11845(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	ARF6 regulates neuron differentiation through glucosylceramide_synthase .
22678786	0	glucosylceramide_synthase	11,36	ERK	59,62	glucosylceramide synthase	ERK	7357	5594	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of glucosylceramide_synthase on P-gp expression by ERK signal transduction pathway in leukemia multi-drug resistance cell line -RSB- .
16959503	0	glucosylceramide_synthase	32,57	GCS	59,62	glucosylceramide synthase	GCS	7357	7357	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	RNAi-mediated inhibition of the glucosylceramide_synthase -LRB- GCS -RRB- gene : A preliminary study towards a therapeutic strategy for Gaucher_disease and other glycosphingolipid storage diseases .
18560890	0	glucosylceramide_synthase	24,49	GCS	51,54	glucosylceramide synthase	GCS	7357	7357	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic relevance of glucosylceramide_synthase -LRB- GCS -RRB- expression in breast_cancer .
22678786	0	glucosylceramide_synthase	11,36	P-gp	40,44	glucosylceramide synthase	P-gp	7357	5243	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of glucosylceramide_synthase on P-gp expression by ERK signal transduction pathway in leukemia multi-drug resistance cell line -RSB- .
26004871	0	glucosylceramide_synthase	10,35	globotriaosylceramide	62,83	glucosylceramide synthase	globotriaosylceramide	7357	53947	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Targeting glucosylceramide_synthase induction of cell surface globotriaosylceramide -LRB- Gb3 -RRB- in acquired cisplatin-resistance of lung_cancer and malignant_pleural_mesothelioma cells .
6214314	0	glue	75,79	Sgs4	94,98	glue	Sgs4	39288(Tax:7227)	31304(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A complex of interacting DNAase I-hypersensitive sites near the Drosophila glue protein gene , Sgs4 .
25774020	0	glued	59,64	p150	54,58	glued	p150	10036	10036	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Cell Cycle-Dependent Localization of Dynactin Subunit p150 -LRB- glued -RRB- at Centrosome .
18249093	0	glut1	21,26	Endothelin-1	0,12	glut1	Endothelin-1	6513	1906	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	Endothelin-1 induces glut1 transcription through enhanced interaction between Sp1 and NF-kappaB transcription factors .
10416860	0	glutamate-aspartate_transporter	12,43	GLAST	45,50	glutamate-aspartate transporter	GLAST	29483(Tax:10116)	29483(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Increase in glutamate-aspartate_transporter -LRB- GLAST -RRB- mRNA during kanamycin-induced cochlear insult in rats .
12204797	0	glutamate_carboxypeptidase_II	15,44	GCPII	46,51	glutamate carboxypeptidase II	GCPII	2346	2346	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Influence of a glutamate_carboxypeptidase_II -LRB- GCPII -RRB- polymorphism -LRB- 1561C -- > T -RRB- on plasma homocysteine , folate and vitamin_B -LRB- 12 -RRB- levels and its relationship to cardiovascular_disease risk .
22304706	0	glutamate_carboxypeptidase_II	23,52	GCPII	54,59	glutamate carboxypeptidase II	GCPII	2346	2346	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Tissue distribution of glutamate_carboxypeptidase_II -LRB- GCPII -RRB- with a focus on the central and peripheral nervous system .
23169655	0	glutamate_carboxypeptidase_II	14,43	GCPII	45,50	glutamate carboxypeptidase II	GCPII	2346	2346	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of glutamate_carboxypeptidase_II -LRB- GCPII -RRB- activity as a treatment for cognitive_impairment in multiple_sclerosis .
9058055	0	glutamate_decarboxylase	27,50	Choline_acetyltransferase	0,25	glutamate decarboxylase	Choline acetyltransferase	24957(Tax:10116)	290567(Tax:10116)	Gene	Gene	calcitonin|amod|START_ENTITY calcitonin|amod|END_ENTITY	Choline_acetyltransferase , glutamate_decarboxylase , tyrosine_hydroxylase , calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea-pig .
9483560	0	glutamate_decarboxylase	106,129	DARPP-32	74,82	glutamate decarboxylase	DARPP-32	2752	84152	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	The dopaminergic innervation of the pigeon telencephalon : distribution of DARPP-32 and co-occurrence with glutamate_decarboxylase and tyrosine_hydroxylase .
1516745	0	glutamate_decarboxylase	38,61	GAD	63,66	glutamate decarboxylase	GAD	24957(Tax:10116)	24957(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Transient increase in expression of a glutamate_decarboxylase -LRB- GAD -RRB- mRNA during the postnatal development of the rat striatum .
6329478	0	glutamate_decarboxylase	25,48	GAD	50,53	glutamate decarboxylase	GAD	396489(Tax:9031)	396489(Tax:9031)	Gene	Gene	control|nmod|START_ENTITY control|appos|END_ENTITY	GABA-mediated control of glutamate_decarboxylase -LRB- GAD -RRB- in cell aggregate culture of chick embryo retina .
8921302	0	glutamate_decarboxylase	4,27	GAD65	65,70	glutamate decarboxylase	GAD65	2752	2572	Gene	Gene	forms|amod|START_ENTITY forms|nmod|END_ENTITY	Two glutamate_decarboxylase forms corresponding to the mammalian GAD65 and GAD67 are expressed during development of the chick telencephalon .
8453948	0	glutamate_decarboxylase	80,103	GAD67	105,110	glutamate decarboxylase	GAD67	24957(Tax:10116)	24379(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The inferior colliculus of GEPRs contains greater numbers of cells that express glutamate_decarboxylase -LRB- GAD67 -RRB- mRNA .
8314014	1	glutamate_decarboxylase	85,108	carboxypeptidase-H	46,64	glutamate decarboxylase	carboxypeptidase-H	24957(Tax:10116)	25669(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of carboxypeptidase-H and insulin but not glutamate_decarboxylase on the beta-cell surface .
9058055	0	glutamate_decarboxylase	27,50	tyrosine_hydroxylase	52,72	glutamate decarboxylase	tyrosine hydroxylase	24957(Tax:10116)	25085(Tax:10116)	Gene	Gene	calcitonin|amod|START_ENTITY calcitonin|amod|END_ENTITY	Choline_acetyltransferase , glutamate_decarboxylase , tyrosine_hydroxylase , calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea-pig .
23038267	0	glutamate_decarboxylase-like_protein_1	8,46	GADL1	48,53	glutamate decarboxylase-like protein 1	GADL1	73748(Tax:10090)	73748(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of glutamate_decarboxylase-like_protein_1 -LRB- GADL1 -RRB- in taurine biosynthesis .
11903050	0	glutamate_dehydrogenase	55,78	GDH	80,83	glutamate dehydrogenase	GDH	2746	2746	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression , purification and characterization of human glutamate_dehydrogenase -LRB- GDH -RRB- allosteric regulatory mutations .
21333382	0	glutamate_dehydrogenase	29,52	GDH	54,57	glutamate dehydrogenase	GDH	2746	2746	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Organ-specific expression of glutamate_dehydrogenase -LRB- GDH -RRB- subunits in yellow lupine .
9520268	0	glutamate_dehydrogenase	21,44	GDH	46,49	glutamate dehydrogenase	GDH	3234478(Tax:69014)	3234478(Tax:69014)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Sequence analysis of glutamate_dehydrogenase -LRB- GDH -RRB- from the hyperthermophilic archaeon Pyrococcus_sp .
23213426	0	glutamate_receptor	15,33	Lola	0,4	glutamate receptor	Lola	33275(Tax:7227)	44548(Tax:7227)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Lola regulates glutamate_receptor expression at the Drosophila neuromuscular junction .
18077702	0	glutamate_receptor_2	33,53	GluR2	55,60	glutamate receptor 2	GluR2	2891	2891	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
18077702	0	glutamate_receptor_2	33,53	PICK1	0,5	glutamate receptor 2	PICK1	2891	9463	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	PICK1 and phosphorylation of the glutamate_receptor_2 -LRB- GluR2 -RRB- AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization .
10822164	0	glutamate_receptor_A	99,119	GluR-A	121,127	glutamate receptor A	GluR-A	50592(Tax:10116)	50592(Tax:10116)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	An autoradiographic study of -LSB- 3H -RSB- AMPA receptor binding and in situ hybridization of AMPA sensitive glutamate_receptor_A -LRB- GluR-A -RRB- subunits following morphine withdrawal in the rat brain .
16326431	0	glutamate_receptor_A	139,159	GluR-A	161,167	glutamate receptor A	GluR-A	50592(Tax:10116)	50592(Tax:10116)	Gene	Gene	subunits|compound|START_ENTITY subunits|appos|END_ENTITY	Increases in -LSB- -LRB- 3 -RRB- H -RSB- - alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic_acid -LRB- AMPA -RRB- receptor binding and mRNA expression of AMPA-sensitive glutamate_receptor_A -LRB- GluR-A -RRB- subunits in rats withdrawn from butorphanol .
20395510	0	glutamate_receptor_delta2	32,57	Cbln1	0,5	glutamate receptor delta2	Cbln1	14804(Tax:10090)	12404(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Cbln1 is a ligand for an orphan glutamate_receptor_delta2 , a bidirectional synapse organizer .
9465309	0	glutamate_receptor_delta_2	10,36	GRID2	43,48	glutamate receptor delta 2	GRID2	2895	2895	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human glutamate_receptor_delta_2 gene -LRB- GRID2 -RRB- maps to chromosome 4q22 .
10644433	0	glutamate_receptor_subunit_3	30,58	GRIA3	65,70	glutamate receptor subunit 3	GRIA3	2892	2892	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the human glutamate_receptor_subunit_3 gene -LRB- GRIA3 -RRB- , a candidate for bipolar_disorder and nonspecific X-linked mental_retardation .
12742080	0	glutamate_transporter	88,109	EAAT2	116,121	glutamate transporter	EAAT2	29483(Tax:10116)	29482(Tax:10116)	Gene	Gene	GLT-1|compound|START_ENTITY expression|nmod|GLT-1 Beta-amyloid|appos|expression Beta-amyloid|parataxis|pathways pathways|nsubj|END_ENTITY	Beta-amyloid and brain-derived_neurotrophic_factor , BDNF , up-regulate the expression of glutamate_transporter GLT-1 / EAAT2 via different signaling pathways utilizing transcription factor NF-kappaB .
19328838	0	glutamate_transporter	94,115	EAAT2	79,84	glutamate transporter	EAAT2	29483(Tax:10116)	29482(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The concentrations and distributions of three C-terminal variants of the GLT1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate_transporter protein in rat brain tissue suggest differential regulation .
10812209	0	glutamate_transporter	22,43	GLAST	45,50	glutamate transporter	GLAST	29483(Tax:10116)	29483(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Effects of ammonia on glutamate_transporter -LRB- GLAST -RRB- protein and mRNA in cultured rat cortical astrocytes .
15509898	0	glutamate_transporter	46,67	GLAST	81,86	glutamate transporter	GLAST	29483(Tax:10116)	29483(Tax:10116)	Gene	Gene	expressions|compound|START_ENTITY expressions|appos|END_ENTITY	Prenatal cannabinoid exposure down - regulates glutamate_transporter expressions -LRB- GLAST and EAAC1 -RRB- in the rat cerebellum .
12533722	0	glutamate_transporter	19,40	GLT-1	41,46	glutamate transporter	GLT-1	29483(Tax:10116)	29482(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Changes of retinal glutamate_transporter GLT-1 mRNA levels following optic_nerve_damage .
16026460	0	glutamate_transporter	29,50	GLT-1	12,17	glutamate transporter	GLT-1	29483(Tax:10116)	29482(Tax:10116)	Gene	Gene	subtype|nmod|START_ENTITY subtype|compound|END_ENTITY	Role of the GLT-1 subtype of glutamate_transporter in glutamate homeostasis : the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus .
21964391	0	glutamate_transporter	61,82	GLT-1	16,21	glutamate transporter	GLT-1	29483(Tax:10116)	29482(Tax:10116)	Gene	Gene	form|nmod|START_ENTITY END_ENTITY|dep|form	Exon 4-skipping GLT-1 : a new form of an abundantly expressed glutamate_transporter .
19328838	0	glutamate_transporter	94,115	GLT1	73,77	glutamate transporter	GLT1	29483(Tax:10116)	29482(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The concentrations and distributions of three C-terminal variants of the GLT1 -LRB- EAAT2 ; slc1a2 -RRB- glutamate_transporter protein in rat brain tissue suggest differential regulation .
15207918	0	glutamate_transporter	23,44	rEAAC1	45,51	glutamate transporter	rEAAC1	29483(Tax:10116)	25550(Tax:10116)	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Modulation of neuronal glutamate_transporter rEAAC1 mRNA expression in rat brain by amitriptyline .
22473056	0	glutamate_transporter-1	137,160	Aquaporin-4	0,11	glutamate transporter-1	Aquaporin-4	20511(Tax:10090)	11829(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY downregulation|nmod|expression involvement|nmod|downregulation plasticity|dep|involvement impairs|dobj|plasticity impairs|nsubj|deficiency deficiency|amod|END_ENTITY	Aquaporin-4 deficiency impairs synaptic plasticity and associative fear memory in the lateral amygdala : involvement of downregulation of glutamate_transporter-1 expression .
23051665	0	glutamate_transporter-1	72,95	Aquaporin-4	0,11	glutamate transporter-1	Aquaporin-4	20511(Tax:10090)	11829(Tax:10090)	Gene	Gene	down-regulation|amod|START_ENTITY suppressing|dobj|down-regulation opioid_dependence|advcl|suppressing opioid_dependence|nsubj|attenuates attenuates|amod|END_ENTITY	Aquaporin-4 deficiency attenuates opioid_dependence through suppressing glutamate_transporter-1 down-regulation and maintaining glutamate homeostasis .
7389640	0	glutamic-pyruvic_transaminase	35,64	GPT	66,69	glutamic-pyruvic transaminase	GPT	2875	2875	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Population studies of the enzyme , glutamic-pyruvic_transaminase -LRB- GPT -RRB- -RSB- .
24086752	0	glutaminase_1	22,35	STAT1	0,5	glutaminase 1	STAT1	2744	6772	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	STAT1 regulates human glutaminase_1 promoter activity through multiple binding sites in HIV-1 infected macrophages .
26528759	0	glutaminase_2	80,93	Myc	0,3	glutaminase 2	Myc	27165	4609	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase_2 .
23574722	0	glutaminase_2	14,27	p63	0,3	glutaminase 2	p63	27165	8626	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p63 regulates glutaminase_2 expression .
15308130	0	glutamine-fructose-6-phosphate_amidotransferase_1	33,82	GFPT1	84,89	glutamine-fructose-6-phosphate amidotransferase 1	GFPT1	2673	2673	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular screening of the human glutamine-fructose-6-phosphate_amidotransferase_1 -LRB- GFPT1 -RRB- gene and association studies with diabetes and diabetic_nephropathy .
21958546	0	glutamine_fructose-6-phosphate_amidotransferase	69,116	GFAT	118,122	glutamine fructose-6-phosphate amidotransferase	GFAT	297417(Tax:10116)	297417(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of 1-arylcarbonyl-6 ,7 - dimethoxyisoquinoline derivatives as glutamine_fructose-6-phosphate_amidotransferase -LRB- GFAT -RRB- inhibitors .
15893507	0	glutamine_synthetase	66,86	TTHA1554	18,26	glutamine synthetase	TTHA1554	3168529(Tax:300852)	3169206(Tax:300852)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Conserved protein TTHA1554 from Thermus_thermophilus_HB8 binds to glutamine_synthetase and cystathionine beta-lyase .
1363402	0	glutamine_synthetase_I	17,39	gsI	41,44	glutamine synthetase I	gsI	33172(Tax:7227)	33172(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the glutamine_synthetase_I -LRB- gsI -RRB- gene produce embryo-lethal female sterility in Drosophila_melanogaster .
15016471	0	glutamine_transaminase_K	12,36	GTK	38,41	glutamine transaminase K	GTK	883	883	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of glutamine_transaminase_K -LRB- GTK -RRB- in sulfur and alpha-keto_acid metabolism in the brain , and in the possible bioactivation of neurotoxicants .
11096076	0	glutaminyl-tRNA_synthetase	55,81	apoptosis_signal-regulating_kinase_1	87,123	glutaminyl-tRNA synthetase	apoptosis signal-regulating kinase 1	5859	4217	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA_synthetase with apoptosis_signal-regulating_kinase_1 .
16158240	0	glutamyl-trna_reductase	85,108	gtr	30,33	glutamyl-trna reductase	gtr	5717992(Tax:3055)	5717992(Tax:3055)	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	The Chlamydomonas_reinhardtii gtr gene encoding the tetrapyrrole biosynthetic enzyme glutamyl-trna_reductase : structure of the gene and properties of the expressed enzyme .
9268642	0	glutamyl_aminopeptidase	41,64	ENPEP	71,76	glutamyl aminopeptidase	ENPEP	2028	2028	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	High-resolution genetic map of the human glutamyl_aminopeptidase gene -LRB- ENPEP -RRB- .
8838810	0	glutaredoxin	19,31	GLRX	33,37	glutaredoxin	GLRX	2745	2745	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for human glutaredoxin -LRB- GLRX -RRB- is localized to human chromosome 5q14 .
17961515	0	glutaredoxin	73,85	Grx2	87,91	glutaredoxin	Grx2	69367(Tax:10090)	69367(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive expression and functional characterization of mitochondrial glutaredoxin -LRB- Grx2 -RRB- in mouse and human brain .
15728668	0	glutaredoxin	29,41	ROXY1	0,5	glutaredoxin	ROXY1	824655(Tax:3702)	820200(Tax:3702)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	ROXY1 , a member of the plant glutaredoxin family , is required for petal development in Arabidopsis_thaliana .
12723971	0	glutaredoxin	21,33	apoptosis_signal-regulating_kinase_1	102,138	glutaredoxin	apoptosis signal-regulating kinase 1	2745	4217	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|nmod|END_ENTITY	Differential role of glutaredoxin and thioredoxin in metabolic oxidative stress-induced activation of apoptosis_signal-regulating_kinase_1 .
10647820	0	glutaredoxin	32,44	grx	46,49	glutaredoxin	grx	93692(Tax:10090)	93692(Tax:10090)	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Cloning and sequencing of mouse glutaredoxin -LRB- grx -RRB- cDNA .
16605247	0	glutaredoxin	47,59	thioltransferase	61,77	glutaredoxin	thioltransferase	2745	2745	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Computational and mutational analysis of human glutaredoxin -LRB- thioltransferase -RRB- : probing the molecular basis of the low pKa of cysteine 22 and its role in catalysis .
18586881	0	glutaredoxin	28,40	thioltransferase	10,26	glutaredoxin	thioltransferase	93692(Tax:10090)	93692(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of thioltransferase -LRB- glutaredoxin -RRB- deletion on cellular sensitivity to oxidative stress and cell proliferation in lens epithelial cells of thioltransferase knockout mouse .
2403567	0	glutaredoxin	53,65	thioltransferase	35,51	glutaredoxin	thioltransferase	2745	397463(Tax:9823)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High-level expression of pig liver thioltransferase -LRB- glutaredoxin -RRB- in Escherichia_coli .
23615448	0	glutaredoxin_3	31,45	PICOT	47,52	glutaredoxin 3	PICOT	10539	10539	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Crucial function of vertebrate glutaredoxin_3 -LRB- PICOT -RRB- in iron homeostasis and hemoglobin maturation .
10773456	0	glutathione-S-transferase	50,75	GST	77,80	glutathione-S-transferase	GST	36927(Tax:7227)	36927(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a new theta-class glutathione-S-transferase -LRB- GST -RRB- gene , gst-3 , from Drosophila_melanogaster .
23644668	0	glutathione-S-transferase	99,124	GST	126,129	glutathione-S-transferase	GST	373156	373156	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The responses of the hepatosomatic index -LRB- HSI -RRB- , 7-ethoxyresorufin-O-deethylase -LRB- EROD -RRB- activity and glutathione-S-transferase -LRB- GST -RRB- activity in sea bass -LRB- Dicentrarchus labrax , Linnaeus 1758 -RRB- caged at a polluted site : implications for their use in environmental risk assessment .
23878968	0	glutathione-S-transferase	49,74	GST	76,79	glutathione-S-transferase	GST	373156	373156	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Isolation , cloning and large scale expression of glutathione-S-transferase -LRB- GST -RRB- protein of Polymyxa betae .
26078397	0	glutathione-S-transferase	13,38	GST	40,43	glutathione-S-transferase	GST	54486(Tax:10090)	54486(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Influence of glutathione-S-transferase -LRB- GST -RRB- inhibition on lung epithelial cell injury : role of oxidative stress and metabolism .
15565566	0	glutathione-S-transferase	25,50	GSTM1	58,63	glutathione-S-transferase	GSTM1	373156	2944	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genetic polymorphisms in glutathione-S-transferase genes -LRB- GSTM1 , GSTT1 , GSTP1 -RRB- and survival after chemotherapy for invasive breast_carcinoma .
11307147	0	glutathione-S-transferase	17,42	GSTP1	50,55	glutathione-S-transferase	GSTP1	373156	2950	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Polymorphisms of glutathione-S-transferase genes -LRB- GSTP1 , GSTM1 and GSTT1 -RRB- and prostate-cancer risk .
19701760	0	glutathione-S-transferase	4,29	Gstt1	50,55	glutathione-S-transferase	Gstt1	373156	2952	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|dep|END_ENTITY	The glutathione-S-transferase gene polymorphisms -LRB- Gstt1 , Gstm1 , and Gstp1 -RRB- in patients with non-allergic_nasal_polyposis .
10773456	0	glutathione-S-transferase	50,75	gst-3	88,93	glutathione-S-transferase	gst-3	36927(Tax:7227)	37106(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a new theta-class glutathione-S-transferase -LRB- GST -RRB- gene , gst-3 , from Drosophila_melanogaster .
25080784	0	glutathione-S-transferase	129,154	interleukins_8_and_10	156,177	glutathione-S-transferase	interleukins 8 and 10	373156	3576;3586	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The association of risk of development of cardiomyopathies with polymorphic variants of genes of angiotensin converting enzyme , glutathione-S-transferase , interleukins_8_and_10 -RSB- .
411659	0	glutathione-S-transferase	33,58	ligandin	19,27	glutathione-S-transferase	ligandin	373156	24422(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	The preparation of ligandin with glutathione-S-transferase activity from porcine liver cytosol affinity chromatography on bromosulphophthalein-Sepharose .
7844900	0	glutathione-S-transferase_M1	18,46	GSTM1	48,53	glutathione-S-transferase M1	GSTM1	2944	2944	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The frequency of glutathione-S-transferase_M1 -LRB- GSTM1 -RRB- gene deletion in patients with lung and oral_cancer -RSB- .
17593093	0	glutathione-S-transferase_P1	24,52	GSTP1	54,59	glutathione-S-transferase P1	GSTP1	2950	2950	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association analysis of glutathione-S-transferase_P1 -LRB- GSTP1 -RRB- polymorphism with urothelial_cancer susceptibility and myelosuppression after M-VAC chemotherapy .
22180037	0	glutathione-S-transferase_P1	28,56	GSTP1	63,68	glutathione-S-transferase P1	GSTP1	2950	2950	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphism of the glutathione-S-transferase_P1 gene -LRB- GSTP1 -RRB- and susceptibility to prostate_cancer in the Kashmiri population .
11556154	0	glutathione-S-transferase_T1	37,65	GST_T1	67,73	glutathione-S-transferase T1	GST T1	2952	2952	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of the human erythrocytic glutathione-S-transferase_T1 -LRB- GST_T1 -RRB- by thimerosal .
17121222	0	glutathione-S-transferase_fusion_protein	15,55	CCL3L1	66,72	glutathione-S-transferase fusion protein	CCL3L1	6294	6349	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	-LSB- Expression of glutathione-S-transferase_fusion_protein and human CCL3L1 protein -RSB- .
19424424	0	glutathione-S_transferase	125,150	GST	152,155	glutathione-S transferase	GST	373156	373156	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Linkage disequilibrium between two high-frequency deletion polymorphisms : implications for association studies involving the glutathione-S_transferase -LRB- GST -RRB- genes .
8375395	0	glutathione-peroxidase	33,55	glutathione_S-transferase	2,27	glutathione-peroxidase	glutathione S-transferase	817715(Tax:3702)	817494(Tax:3702)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	A glutathione_S-transferase with glutathione-peroxidase activity from Arabidopsis_thaliana .
12408568	0	glutathione_S-transferase	56,81	GST	92,95	glutathione S-transferase	GST	373156	373156	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of three fungicides alone and in combination on glutathione_S-transferase activity -LRB- GST -RRB- and cytochrome_P-450 _ -LRB- CYP_1A1 -RRB- in the liver and gill of brown trout -LRB- Salmo trutta -RRB- .
1399740	0	glutathione_S-transferase	31,56	GST	58,61	glutathione S-transferase	GST	373156	373156	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Cellular glutathione -LRB- GSH -RRB- and glutathione_S-transferase -LRB- GST -RRB- activity in human ovarian_tumor biopsies following exposure to alkylating agents .
1635913	0	glutathione_S-transferase	9,34	GST	36,39	glutathione S-transferase	GST	58962(Tax:10116)	58962(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Enhanced glutathione_S-transferase -LRB- GST -RRB- activity in pregnant rats treated with benzo -LRB- a -RRB- pyrene .
18094897	0	glutathione_S-transferase	46,71	GST	73,76	glutathione S-transferase	GST	373156	373156	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Comparative analysis of the prevalence of the glutathione_S-transferase -LRB- GST -RRB- system in malignant and benign_thyroid_tumor cells .
19917083	0	glutathione_S-transferase	27,52	GST	54,57	glutathione S-transferase	GST	373156	373156	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Examination of polymorphic glutathione_S-transferase -LRB- GST -RRB- genes , tobacco smoking and prostate_cancer risk among men of African descent : a case-control study .
21276481	0	glutathione_S-transferase	80,105	GST	107,110	glutathione S-transferase	GST	36927(Tax:7227)	36927(Tax:7227)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Identification , characterization and expression profiles of Chironomus riparius glutathione_S-transferase -LRB- GST -RRB- genes in response to cadmium and silver nanoparticles exposure .
21458595	0	glutathione_S-transferase	12,37	GST	39,42	glutathione S-transferase	GST	373156	373156	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Response of glutathione_S-transferase -LRB- GST -RRB- genes to cadmium exposure in the marine pollution indicator worm , Perinereis nuntia .
7639695	0	glutathione_S-transferase	38,63	GST	65,68	glutathione S-transferase	GST	373156	373156	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Octopus S-crystallins with endogenous glutathione_S-transferase -LRB- GST -RRB- activity : sequence comparison and evolutionary relationships with authentic GST enzymes .
7937598	0	glutathione_S-transferase	17,42	GST	44,47	glutathione S-transferase	GST	58962(Tax:10116)	58962(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Modifications of glutathione_S-transferase -LRB- GST -RRB- activity in the last period of pregnancy in rats treated with benzo -LRB- a -RRB- pyrene -LRB- BP -RRB- .
10779639	0	glutathione_S-transferase	17,42	GSTM1	50,55	glutathione S-transferase	GSTM1	373156	2944	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Polymorphisms of glutathione_S-transferase genes -LRB- GSTM1 , GSTP1 and GSTT1 -RRB- and breast_cancer susceptibility .
20354063	0	glutathione_S-transferase	25,50	GSTM1	57,62	glutathione S-transferase	GSTM1	373156	2944	Gene	Gene	genes|amod|START_ENTITY polymorphisms|nmod|genes polymorphisms|dep|END_ENTITY	Genetic polymorphisms of glutathione_S-transferase genes GSTM1 , GSTT1 and risk of coronary_heart_disease .
23185284	0	glutathione_S-transferase	25,50	GSTM1	57,62	glutathione S-transferase	GSTM1	373156	2944	Gene	Gene	genes|amod|START_ENTITY polymorphisms|nmod|genes polymorphisms|dep|END_ENTITY	Genetic polymorphisms of glutathione_S-transferase genes GSTM1 , GSTT1 and risk of hepatocellular_carcinoma .
25969820	0	glutathione_S-transferase	15,40	GSTM1	42,47	glutathione S-transferase	GSTM1	373156	2944	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association of glutathione_S-transferase -LRB- GSTM1 and GSTT1 -RRB- genes with chronic_myeloid_leukemia .
16039055	0	glutathione_S-transferase	39,64	GSTP1	66,71	glutathione S-transferase	GSTP1	373156	2950	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association study between a functional glutathione_S-transferase -LRB- GSTP1 -RRB- gene polymorphism -LRB- Ile105Val -RRB- and tardive_dyskinesia .
9511175	0	glutathione_S-transferase	4,29	GSTP1	30,35	glutathione S-transferase	GSTP1	373156	2950	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	The glutathione_S-transferase GSTP1 polymorphism : effects on susceptibility to oral/pharyngeal and laryngeal_carcinomas .
16624155	0	glutathione_S-transferase	16,41	GSTT1	43,48	glutathione S-transferase	GSTT1	373156	2952	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	-LSB- The effects of glutathione_S-transferase -LRB- GSTT1 and GSTM1 -RRB- genes polymorphisms on treatment efficacy and prognosis of acute_myeloid_leukemia -RSB- .
23444902	0	glutathione_S-transferase	19,44	GSTT1	71,76	glutathione S-transferase	GSTT1	373156	2952	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	The association of glutathione_S-transferase gene mutations -LRB- including GSTT1 and GSTM1 -RRB- with the prognostic factors and relapse in acute_lymphoblastic_leukemia .
11179824	0	glutathione_S-transferase	56,81	GSTa1	82,87	glutathione S-transferase	GSTa1	54486(Tax:10090)	14857(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Polymorphic electrophile response elements in the mouse glutathione_S-transferase GSTa1 gene that confer increased induction .
18245335	0	glutathione_S-transferase	91,116	GstD1	123,128	glutathione S-transferase	GstD1	48337(Tax:7227)	41503(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The molecular basis of host adaptation in cactophilic Drosophila : molecular evolution of a glutathione_S-transferase gene -LRB- GstD1 -RRB- in Drosophila_mojavensis .
11991805	0	glutathione_S-transferase	112,137	Gsta1	138,143	glutathione S-transferase	Gsta1	54486(Tax:10090)	14857(Tax:10090)	Gene	Gene	Gstm3|compound|START_ENTITY Gstm3|compound|END_ENTITY	Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione_S-transferase Gsta1 , Gsta2 , Gstm1 , Gstm2 , Gstm3 and Gstm4 genes in the livers of male and female mice .
2254303	0	glutathione_S-transferase	132,157	Yb2	107,110	glutathione S-transferase	Yb2	58962(Tax:10116)	83807(Tax:10116)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Isozyme specificity in the conversion of hepoxilin_A3 -LRB- HxA3 -RRB- into a glutathionyl_hepoxilin -LRB- HxA3-C -RRB- by the Yb2 subunit of rat liver glutathione_S-transferase .
2867080	0	glutathione_S-transferase	35,60	glucose-6-phosphate_dehydrogenase	66,99	glutathione S-transferase	glucose-6-phosphate dehydrogenase	58962(Tax:10116)	24377(Tax:10116)	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the various forms of glutathione_S-transferase with glucose-6-phosphate_dehydrogenase and gamma-glutamyltranspeptidase as markers of preneoplastic and neoplastic_lesions in rat kidney induced by N-ethyl-N-hydroxyethylnitrosamine .
8375395	0	glutathione_S-transferase	2,27	glutathione-peroxidase	33,55	glutathione S-transferase	glutathione-peroxidase	817494(Tax:3702)	817715(Tax:3702)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	A glutathione_S-transferase with glutathione-peroxidase activity from Arabidopsis_thaliana .
14719182	0	glutathione_S-transferase_P1	37,65	GSTP1	72,77	glutathione S-transferase P1	GSTP1	2950	2950	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between a variant of the glutathione_S-transferase_P1 gene -LRB- GSTP1 -RRB- and hypertension in pregnancy in Japanese : interaction with parity , age , and genetic factors .
22320983	0	glutathione_S-transferase_P1	49,77	GSTP1	84,89	glutathione S-transferase P1	GSTP1	2950	2950	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter methylation and genetic polymorphism of glutathione_S-transferase_P1 gene -LRB- GSTP1 -RRB- in Thai breast - _ cancer patients .
24205873	0	glutathione_S-transferase_P1	15,43	GSTP1	45,50	glutathione S-transferase P1	GSTP1	2950	2950	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of glutathione_S-transferase_P1 -LRB- GSTP1 -RRB- polymorphism with Tourette_syndrome in Taiwanese patients .
19254954	0	glutathione_S-transferase_P1	38,66	epidermal_growth_factor_receptor	70,102	glutathione S-transferase P1	epidermal growth factor receptor	2950	1956	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of the human glutathione_S-transferase_P1 by epidermal_growth_factor_receptor .
14623254	0	glutathione_S-transferase_P1-1	14,44	GATA-1	78,84	glutathione S-transferase P1-1	GATA-1	2950	2623	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of glutathione_S-transferase_P1-1 in differentiating K562 : role of GATA-1 .
22047626	0	glutathione_S-transferase_P1-1	195,225	GSTP1-1	227,234	glutathione S-transferase P1-1	GSTP1-1	2950	2950	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Oral ezatiostat HCl -LRB- Telintra , TLK199 -RRB- and idiopathic_chronic_neutropenia -LRB- ICN -RRB- : a case report of complete response of a patient with G-CSF resistant ICN following treatment with ezatiostat , a glutathione_S-transferase_P1-1 -LRB- GSTP1-1 -RRB- inhibitor .
25218501	0	glutathione_S-transferase_P1-1	6,36	estrogen_receptor_a	53,72	glutathione S-transferase P1-1	estrogen receptor a	2950	2099	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	Human glutathione_S-transferase_P1-1 functions as an estrogen_receptor_a signaling modulator .
16874663	0	glutathione_S-transferase_T1	14,42	GSTT1	44,49	glutathione S-transferase T1	GSTT1	2952	2952	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of glutathione_S-transferase_T1 -LRB- GSTT1 -RRB- in human brain_tumours .
12500666	0	glutathione_S-transferase_T1	16,44	M1_and_P1	46,55	glutathione S-transferase T1	M1 and P1	2952	100507027	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Polymorphism of glutathione_S-transferase_T1 , M1_and_P1 genes in a Shanghai population : patients with occupational or non-occupational_bladder_cancer .
15318035	0	glutathione_peroxidase	57,79	GPX1	81,85	glutathione peroxidase	GPX1	2876	2876	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between the Pro197Leu polymorphism in the glutathione_peroxidase -LRB- GPX1 -RRB- gene and schizophrenia .
16413612	0	glutathione_peroxidase	36,58	GPX1	60,64	glutathione peroxidase	GPX1	2876	2876	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Genetic association analysis of the glutathione_peroxidase -LRB- GPX1 -RRB- gene polymorphism -LRB- Pro197Leu -RRB- with tardive_dyskinesia .
20877264	0	glutathione_peroxidase	49,71	GPX1	73,77	glutathione peroxidase	GPX1	2876	2876	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association of C599T polymorphism in the glutathione_peroxidase -LRB- GPX1 -RRB- gene with delayed graft function , acute kidney graft rejection and chronic allograft nephropathy .
18267129	0	glutathione_peroxidase	101,123	GPx1	125,129	glutathione peroxidase	GPx1	24404(Tax:10116)	24404(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Sensitization by docosahexaenoic_acid -LRB- DHA -RRB- of breast_cancer cells to anthracyclines through loss of glutathione_peroxidase -LRB- GPx1 -RRB- response .
21980510	0	glutathione_peroxidase	2,24	PEPT-1	102,108	glutathione peroxidase	PEPT-1	172983(Tax:6239)	180919(Tax:6239)	Gene	Gene	regulate|nsubj|START_ENTITY regulate|dobj|END_ENTITY	A glutathione_peroxidase , intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. _ elegans .
11410332	0	glutathione_peroxidase	38,60	Thioredoxin_reductase	0,21	glutathione peroxidase	Thioredoxin reductase	2876	25824	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Thioredoxin_reductase and cytoplasmic glutathione_peroxidase activity in human foetal_and_neonatal_liver .
15331559	0	glutathione_peroxidase-1	27,51	GPx-1	53,58	glutathione peroxidase-1	GPx-1	2876	2876	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional variants in the glutathione_peroxidase-1 -LRB- GPx-1 -RRB- gene are associated with increased intima-media_thickness of carotid arteries and risk of macrovascular_diseases in japanese type 2 diabetic patients .
12804009	0	glutathione_peroxidase-1	144,168	Gpx1	170,174	glutathione peroxidase-1	Gpx1	14775(Tax:10090)	14775(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	An imbalance in antioxidant defense affects cellular function : the pathophysiological consequences of a reduction in antioxidant defense in the glutathione_peroxidase-1 -LRB- Gpx1 -RRB- knockout mouse .
22307228	0	glutathione_peroxidase-1	38,62	Transforming_growth_factor-b1	0,29	glutathione peroxidase-1	Transforming growth factor-b1	2876	7040	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-b1 induces glutathione_peroxidase-1 and protects from H2O2-induced cell death in colon_cancer cells via the Smad2/ERK1/2 / HIF-1a pathway .
23472740	0	glutathione_peroxidase-1	16,40	glial_cell_line-derived_neurotrophic_factor	68,111	glutathione peroxidase-1	glial cell line-derived neurotrophic factor	24404(Tax:10116)	25453(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of glutathione_peroxidase-1 expression and activity by glial_cell_line-derived_neurotrophic_factor promotes high-level protection of PC12 cells against 6-hydroxydopamine and hydrogen_peroxide toxicities .
24176350	0	glutathione_peroxidase-1	73,97	glutathione_peroxidase-2	116,140	glutathione peroxidase-1	glutathione peroxidase-2	24404(Tax:10116)	29326(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Selenium-enriched Agaricus bisporus increases expression and activity of glutathione_peroxidase-1 and expression of glutathione_peroxidase-2 in rat colon .
24176350	0	glutathione_peroxidase-2	116,140	glutathione_peroxidase-1	73,97	glutathione peroxidase-2	glutathione peroxidase-1	29326(Tax:10116)	24404(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Selenium-enriched Agaricus bisporus increases expression and activity of glutathione_peroxidase-1 and expression of glutathione_peroxidase-2 in rat colon .
16890189	0	glutathione_peroxidase-3	54,78	c-maf	82,87	glutathione peroxidase-3	c-maf	14778(Tax:10090)	17132(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Correlation between the expression level of c-maf and glutathione_peroxidase-3 in c-maf - / - mice kidney and c-maf overexpressed renal tubular cells .
25606455	0	glutathione_peroxidase1	28,51	GPx1	53,57	glutathione peroxidase1	GPx1	2876	2876	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Lack of association between glutathione_peroxidase1 -LRB- GPx1 -RRB- activity , Pro198Leu polymorphism and stenosis of coronary arteries : A population-based prediction .
21993316	0	glutathione_peroxidase_1	40,64	GPx1	66,70	glutathione peroxidase 1	GPx1	2876	2876	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between genetic variants in glutathione_peroxidase_1 -LRB- GPx1 -RRB- gene , GPx activity and the risk of prostate_cancer .
22512980	0	glutathione_peroxidase_1	46,70	selenium-binding_protein_1	10,36	glutathione peroxidase 1	selenium-binding protein 1	2876	8991	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Decreased selenium-binding_protein_1 enhances glutathione_peroxidase_1 activity and downregulates HIF-1a to promote hepatocellular_carcinoma invasiveness .
17937616	0	glutathione_peroxidase_2	18,42	GPx2	44,48	glutathione peroxidase 2	GPx2	2877	2877	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Activation of the glutathione_peroxidase_2 -LRB- GPx2 -RRB- promoter by beta-catenin .
25333265	0	glutathione_peroxidase_3	47,71	GPx3	73,77	glutathione peroxidase 3	GPx3	2878	2878	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance and therapeutic value of glutathione_peroxidase_3 -LRB- GPx3 -RRB- in hepatocellular_carcinoma .
18593884	0	glutathione_peroxidase_4	28,52	guanine-rich_sequence-binding_factor_1	72,110	glutathione peroxidase 4	guanine-rich sequence-binding factor 1	625249(Tax:10090)	231413(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Translational regulation of glutathione_peroxidase_4 expression through guanine-rich_sequence-binding_factor_1 is essential for embryonic brain development .
10542376	0	glutathione_peroxidase_5	43,67	GPX5	77,81	glutathione peroxidase 5	GPX5	14780(Tax:10090)	14780(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Selenium-independent epididymis-restricted glutathione_peroxidase_5 protein -LRB- GPX5 -RRB- can back up failing Se-dependent GPXs in mice subjected to selenium deficiency .
2306116	0	glutathione_reductase	14,35	oncomodulin	39,50	glutathione reductase	oncomodulin	116686(Tax:10116)	100357024(Tax:9986)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glutathione_reductase by oncomodulin .
9512666	0	glutathione_synthetase	28,50	GSH2	52,56	glutathione synthetase	GSH2	854108(Tax:4932)	854108(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular identification of glutathione_synthetase -LRB- GSH2 -RRB- gene from Saccharomyces_cerevisiae .
23888047	0	glutathione_transferase_Omega_1	11,42	GSTO1-1	44,51	glutathione transferase Omega 1	GSTO1-1	9446	9446	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for glutathione_transferase_Omega_1 -LRB- GSTO1-1 -RRB- in the glutathionylation cycle .
12019185	0	glutathione_transferase_zeta	49,77	GSTZ1-1	79,86	glutathione transferase zeta	GSTZ1-1	681913(Tax:10116)	681913(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization and activity of glutathione_transferase_zeta -LRB- GSTZ1-1 -RRB- in rat tissues .
21642471	0	glutathione_transferase_zeta_1	27,57	maleylacetoacetate_isomerase	58,86	glutathione transferase zeta 1	maleylacetoacetate isomerase	2954	2954	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Human polymorphisms in the glutathione_transferase_zeta_1 / maleylacetoacetate_isomerase gene influence the toxicokinetics of dichloroacetate .
19287002	0	glyceraldehyde-3-phosphate_dehydrogenase	86,126	CP12	0,4	glyceraldehyde-3-phosphate dehydrogenase	CP12	5715019(Tax:3055)	5719874(Tax:3055)	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	CP12 from Chlamydomonas_reinhardtii , a permanent specific `` chaperone-like '' protein of glyceraldehyde-3-phosphate_dehydrogenase .
11792468	0	glyceraldehyde-3-phosphate_dehydrogenase	27,67	GAPDH	69,74	glyceraldehyde-3-phosphate dehydrogenase	GAPDH	2597	2597	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Differential alteration of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- mRNA in the central nervous system of hens treated with diisopropylphosphorofluoridate -LRB- DFP -RRB- .
11821985	0	glyceraldehyde-3-phosphate_dehydrogenase	27,67	GAPDH	69,74	glyceraldehyde-3-phosphate dehydrogenase	GAPDH	100009074(Tax:9986)	100009074(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- , beta actin and hypoxanthine_phosphoribosyltransferase _ -LRB- HPRT -RRB- _ in_postnatal_rabbit_sclera .
11891433	0	glyceraldehyde-3-phosphate_dehydrogenase	13,53	GAPDH	55,60	glyceraldehyde-3-phosphate dehydrogenase	GAPDH	24383(Tax:10116)	24383(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- expression in rat brain after focal ischemia/reperfusion .
19123030	0	glyceraldehyde-3-phosphate_dehydrogenase	24,64	GAPDH	66,71	glyceraldehyde-3-phosphate dehydrogenase	GAPDH	2597	2597	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- gene from the halotolerant alga Dunaliella_salina and inhibition of its expression by RNAi .
20586183	0	glyceraldehyde-3-phosphate_dehydrogenase	53,93	GAPDH	100,105	glyceraldehyde-3-phosphate dehydrogenase	GAPDH	100478741	100478741	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	cDNA , genomic sequence cloning and overexpression of glyceraldehyde-3-phosphate_dehydrogenase gene -LRB- GAPDH -RRB- from the Giant_Panda .
22371187	0	glyceraldehyde-3-phosphate_dehydrogenase	8,48	GAPDH	50,55	glyceraldehyde-3-phosphate dehydrogenase	GAPDH	2597	2597	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	A novel glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- promoter for expressing transgenes in the halotolerant alga Dunaliella_salina .
23086952	0	glyceraldehyde-3-phosphate_dehydrogenase	36,76	GAPDH	78,83	glyceraldehyde-3-phosphate dehydrogenase	GAPDH	2597	2597	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Human and pneumococcal cell surface glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- proteins are both ligands of human C1q protein .
12697324	0	glyceraldehyde-3-phosphate_dehydrogenase	21,61	HIF-2alpha	0,10	glyceraldehyde-3-phosphate dehydrogenase	HIF-2alpha	2597	2034	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HIF-2alpha regulates glyceraldehyde-3-phosphate_dehydrogenase expression in endothelial cells .
11821985	0	glyceraldehyde-3-phosphate_dehydrogenase	27,67	HPRT	132,136	glyceraldehyde-3-phosphate dehydrogenase	HPRT	100009074(Tax:9986)	100126071(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- , beta actin and hypoxanthine_phosphoribosyltransferase _ -LRB- HPRT -RRB- _ in_postnatal_rabbit_sclera .
17521179	0	glyceraldehyde-3-phosphate_dehydrogenase	40,80	Microtubule-associated_protein_1B	0,33	glyceraldehyde-3-phosphate dehydrogenase	Microtubule-associated protein 1B	24383(Tax:10116)	29456(Tax:10116)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Microtubule-associated_protein_1B binds glyceraldehyde-3-phosphate_dehydrogenase .
19106097	0	glyceraldehyde-3-phosphate_dehydrogenase	14,54	Rab2	0,4	glyceraldehyde-3-phosphate dehydrogenase	Rab2	2597	5862	Gene	Gene	utilizes|amod|START_ENTITY utilizes|nummod|END_ENTITY	Rab2 utilizes glyceraldehyde-3-phosphate_dehydrogenase and protein kinase C -LCB- iota -RCB- to associate with microtubules and to recruit dynein .
22062951	0	glyceraldehyde-3-phosphate_dehydrogenase	20,60	transferrin_receptor	72,92	glyceraldehyde-3-phosphate dehydrogenase	transferrin receptor	2597	7037	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of glyceraldehyde-3-phosphate_dehydrogenase as a novel transferrin_receptor .
1924305	0	glyceraldehyde-3-phosphate_dehydrogenase	64,104	uracil_DNA_glycosylase	16,38	glyceraldehyde-3-phosphate dehydrogenase	uracil DNA glycosylase	2597	7374	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	A human nuclear uracil_DNA_glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate_dehydrogenase .
11142398	0	glycerol-3-phosphate_dehydrogenase	72,106	GUT2	113,117	glycerol-3-phosphate dehydrogenase	GUT2	854651(Tax:4932)	854651(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Carbon source-dependent transcriptional regulation of the mitochondrial glycerol-3-phosphate_dehydrogenase gene , GUT2 , from Saccharomyces_cerevisiae .
1676389	0	glycerol-3-phosphate_dehydrogenase	61,95	GUT2	97,101	glycerol-3-phosphate dehydrogenase	GUT2	854651(Tax:4932)	854651(Tax:4932)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Cloning and characterisation of the Saccharomyces_cerevisiae glycerol-3-phosphate_dehydrogenase -LRB- GUT2 -RRB- promoter .
20857217	0	glycerol-3-phosphate_dehydrogenase_1	53,89	GPD1	91,95	glycerol-3-phosphate dehydrogenase 1	GPD1	100153250(Tax:9823)	100153250(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characteristics and expression profiles of glycerol-3-phosphate_dehydrogenase_1 -LRB- GPD1 -RRB- gene in pig .
17967976	0	glycerol-3-phosphate_dehydrogenase_1	51,87	GPD1-L	99,105	glycerol-3-phosphate dehydrogenase 1	GPD1-L	2819	23171	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular and functional characterization of novel glycerol-3-phosphate_dehydrogenase_1 like gene -LRB- GPD1-L -RRB- mutations in sudden_infant_death_syndrome .
17967977	0	glycerol-3-phosphate_dehydrogenase_1	12,48	GPD1-L	60,66	glycerol-3-phosphate dehydrogenase 1	GPD1-L	2819	23171	Gene	Gene	gene|amod|START_ENTITY Mutation|nmod|gene Mutation|appos|END_ENTITY	Mutation in glycerol-3-phosphate_dehydrogenase_1 like gene -LRB- GPD1-L -RRB- decreases cardiac Na + current and causes inherited arrhythmias .
15531216	0	glycerol_dehydrogenase	79,101	Seb1	40,44	glycerol dehydrogenase	Seb1	853106(Tax:4932)	856821(Tax:4932)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	The fungal STRE-element-binding protein Seb1 is involved but not essential for glycerol_dehydrogenase -LRB- gld1 -RRB- gene expression and glycerol accumulation in Trichoderma atroviride during osmotic stress .
815919	0	glycine-N-acyltransferase	123,148	UDP-glucuronosyl_transferase	39,67	glycine-N-acyltransferase	UDP-glucuronosyl transferase	293779(Tax:10116)	24862(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Drug conjugation in Gunn_rats : reduced UDP-glucuronosyl_transferase and UDP-glucosyl transferase activities with increased glycine-N-acyltransferase activity .
17287892	0	glycine-rich_protein_AtGRP9	48,75	AtCAD5	101,107	glycine-rich protein AtGRP9	AtCAD5	815093(Tax:3702)	829572(Tax:3702)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Root and vascular tissue-specific expression of glycine-rich_protein_AtGRP9 and its interaction with AtCAD5 , a cinnamyl_alcohol_dehydrogenase , in Arabidopsis_thaliana .
20925583	0	glycine_N-acyltransferase	25,50	GLYAT	52,57	glycine N-acyltransferase	GLYAT	10249	10249	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Genetic polymorphisms of glycine_N-acyltransferase -LRB- GLYAT -RRB- in a French Caucasian population .
11389164	0	glycine_receptor_alpha1_subunit	17,48	GLRA1	50,55	glycine receptor alpha1 subunit	GLRA1	2741	2741	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the glycine_receptor_alpha1_subunit -LRB- GLRA1 -RRB- gene in hereditary hyperekplexia pedigrees : evidence for non-penetrance of mutation Y279C .
16964444	0	glycine_receptor_alpha_1_subunit	51,83	Nmf11	0,5	glycine receptor alpha 1 subunit	Nmf11	14654(Tax:10090)	14654(Tax:10090)	Gene	Gene	mutation|nmod|START_ENTITY mutation|nsubj|END_ENTITY	Nmf11 is a novel ENU-induced mutation in the mouse glycine_receptor_alpha_1_subunit .
9676428	0	glycine_receptor_beta_subunit	10,39	GLRB	46,50	glycine receptor beta subunit	GLRB	2743	2743	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human glycine_receptor_beta_subunit gene -LRB- GLRB -RRB- : structure , refined chromosomal localization , and population polymorphism .
18709358	0	glycine_transport_1	43,62	GlyT1	75,80	glycine transport 1	GlyT1	116509(Tax:10116)	116509(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Procognitive and antipsychotic efficacy of glycine_transport_1 inhibitors -LRB- GlyT1 -RRB- in acute and neurodevelopmental models of schizophrenia : latent_inhibition studies in the rat .
12602503	0	glycine_transporter	33,52	Glyt-1	54,60	glycine transporter	Glyt-1	116509(Tax:10116)	116509(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of astrocytic glycine_transporter -LRB- Glyt-1 -RRB- in acute_liver_failure .
22542656	0	glycine_transporter-1	8,29	GlyT1	31,36	glycine transporter-1	GlyT1	116509(Tax:10116)	116509(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A novel glycine_transporter-1 -LRB- GlyT1 -RRB- inhibitor , ASP2535 -LRB- 4 - -LSB- 3-isopropyl-5 - -LRB- 6-phenyl-3-pyridyl -RRB- -4 H-1 ,2,4 - triazol-4-yl -RSB- -2,1,3 - benzoxadiazole -RRB- , improves cognition in animal models of cognitive_impairment in schizophrenia and Alzheimer 's _ disease .
15276154	0	glycine_transporter_2	13,34	syntenin-1	73,83	glycine transporter 2	syntenin-1	171148(Tax:10116)	83841(Tax:10116)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The neuronal glycine_transporter_2 interacts with the PDZ domain protein syntenin-1 .
24060634	0	glycodelin-A	31,43	KLF11	0,5	glycodelin-A	KLF11	5047	8462	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	KLF11 epigenetically regulates glycodelin-A , a marker of endometrial biology via histone-modifying chromatin mechanisms .
2657401	0	glycogen_phosphorylase	46,68	GPH1	22,26	glycogen phosphorylase	GPH1	856289(Tax:4932)	856289(Tax:4932)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Molecular analysis of GPH1 , the gene encoding glycogen_phosphorylase in Saccharomyces_cerevisiae .
11796108	0	glycogen_phosphorylase_b	92,116	phosphorylase_kinase	31,51	glycogen phosphorylase b	phosphorylase kinase	5834	5256	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Three-dimensional structure of phosphorylase_kinase at 22 A resolution and its complex with glycogen_phosphorylase_b .
24215078	0	glycogen_synthase	37,54	GYS1	56,60	glycogen synthase	GYS1	100054723(Tax:9796)	100054723(Tax:9796)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Evidence of positive selection for a glycogen_synthase -LRB- GYS1 -RRB- mutation in domestic_horse populations .
24258790	0	glycogen_synthase_2	4,23	Gys2	30,34	glycogen synthase 2	Gys2	2998	2998	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The glycogen_synthase_2 gene -LRB- Gys2 -RRB- displays parallel evolution between Old World and New World fruit bats .
11707456	0	glycogen_synthase_kinase-3	54,80	Axin	22,26	glycogen synthase kinase-3	Axin	779056(Tax:8355)	398097(Tax:8355)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the Axin and Frat binding region of glycogen_synthase_kinase-3 .
21208504	0	glycogen_synthase_kinase-3	35,61	GSK3	63,67	glycogen synthase kinase-3	GSK3	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Evidence for antimanic efficacy of glycogen_synthase_kinase-3 -LRB- GSK3 -RRB- inhibitors in a strain-specific model of acute mania .
21383016	0	glycogen_synthase_kinase-3b	51,78	GSK-3b	80,86	glycogen synthase kinase-3b	GSK-3b	2932	2932	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	AMP-activated_protein_kinase -LRB- AMPK -RRB- activation and glycogen_synthase_kinase-3b -LRB- GSK-3b -RRB- inhibition induce Ca2 + - independent deposition of tight junction components at the plasma membrane .
26888388	0	glycogen_synthase_kinase-3b	11,38	GSK-3b	40,46	glycogen synthase kinase-3b	GSK-3b	84027(Tax:10116)	84027(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	-LSB- Impact of glycogen_synthase_kinase-3b -LRB- GSK-3b -RRB- inhibitor on Wnt and NF-kB signal pathways in a rat model of diabetic_nephropathy -RSB- .
20827300	0	glycogen_synthase_kinase-3b	84,111	GSK-3beta	113,122	glycogen synthase kinase-3b	GSK-3beta	2932	2932	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Integrin-linked_kinase is a functional Mn2 + - dependent protein kinase that regulates glycogen_synthase_kinase-3b -LRB- GSK-3beta -RRB- phosphorylation .
22184106	0	glycogen_synthase_kinase-3b	86,113	GSK3b	115,120	glycogen synthase kinase-3b	GSK3b	2932	2932	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Prolyl isomerase Pin1 promotes amyloid_precursor_protein -LRB- APP -RRB- turnover by inhibiting glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- activity : novel mechanism for Pin1 to protect against Alzheimer_disease .
22489897	0	glycogen_synthase_kinase-3b	47,74	GSK3b	76,81	glycogen synthase kinase-3b	GSK3b	2932	2932	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of novel potent and highly selective glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- inhibitors for Alzheimer 's _ disease : design , synthesis , and characterization of pyrazines .
25461676	0	glycogen_synthase_kinase-3b	74,101	GSK3b	103,108	glycogen synthase kinase-3b	GSK3b	2932	2932	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple alternative splicing and differential expression patterns of the glycogen_synthase_kinase-3b -LRB- GSK3b -RRB- gene in Schizothorax prenanti .
23824844	0	glycogen_synthase_kinase-3b	23,50	TGF-b1	54,60	glycogen synthase kinase-3b	TGF-b1	2932	7040	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|compound|END_ENTITY	Requirement for active glycogen_synthase_kinase-3b in TGF-b1 upregulation of connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- levels in human gingival fibroblasts .
23824844	0	glycogen_synthase_kinase-3b	23,50	connective_tissue_growth_factor	77,108	glycogen synthase kinase-3b	connective tissue growth factor	2932	1490	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Requirement for active glycogen_synthase_kinase-3b in TGF-b1 upregulation of connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- levels in human gingival fibroblasts .
26546129	0	glycogen_synthase_kinase-3b	88,115	disrupted_in_schizophrenia_1	18,46	glycogen synthase kinase-3b	disrupted in schizophrenia 1	2932	27185	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Beyond the brain : disrupted_in_schizophrenia_1 regulates pancreatic b-cell function via glycogen_synthase_kinase-3b .
21278055	0	glycogen_synthase_kinase-3b	15,42	p21	71,74	glycogen synthase kinase-3b	p21	2932	1026	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|expression expression|amod|END_ENTITY	Involvement of glycogen_synthase_kinase-3b in arsenic_trioxide-induced p21 expression .
21864408	0	glycogen_synthase_kinase-3b	42,69	p21	93,96	glycogen synthase kinase-3b	p21	2932	644914	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Phosphatidylinositol 3 ' - kinase , mTOR , and glycogen_synthase_kinase-3b mediated regulation of p21 in human urothelial_carcinoma cells .
12951189	0	glycogen_synthase_kinase-3beta	33,63	GSK3beta	65,73	glycogen synthase kinase-3beta	GSK3beta	100348842(Tax:9986)	100348842(Tax:9986)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Prenatal cocaine exposure alters glycogen_synthase_kinase-3beta -LRB- GSK3beta -RRB- pathway in select rabbit brain areas .
17237295	0	glycogen_synthase_kinase-3beta	52,82	NAG-1	42,47	glycogen synthase kinase-3beta	NAG-1	2932	9518	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Prodigiosin induces the proapoptotic gene NAG-1 via glycogen_synthase_kinase-3beta activity in human breast_cancer cells .
9689133	0	glycogen_synthase_kinase-3beta	29,59	Presenilin_1	0,12	glycogen synthase kinase-3beta	Presenilin 1	2932	5663	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Presenilin_1 associates with glycogen_synthase_kinase-3beta and its substrate tau .
11104755	0	glycogen_synthase_kinase-3beta	18,48	beta-catenin	121,133	glycogen synthase kinase-3beta	beta-catenin	2932	1499	Gene	Gene	site|amod|START_ENTITY Substitution|nmod|site separates|nsubj|Substitution separates|nmod|signaling signaling|amod|END_ENTITY	Substitution of a glycogen_synthase_kinase-3beta phosphorylation site in presenilin_1 separates presenilin function from beta-catenin signaling .
18957842	0	glycogen_synthase_kinase-3beta	113,143	beta-catenin	144,156	glycogen synthase kinase-3beta	beta-catenin	2932	1499	Gene	Gene	/|amod|START_ENTITY vitro|nmod|/ signaling|amod|vitro signaling|amod|END_ENTITY	Lithium_chloride preconditioning optimizes skeletal myoblast functions for cellular cardiomyoplasty in vitro via glycogen_synthase_kinase-3beta / beta-catenin signaling .
19190323	0	glycogen_synthase_kinase-3beta	117,147	beta-catenin	28,40	glycogen synthase kinase-3beta	beta-catenin	2932	1499	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity signaling|nmod|regulation signaling|nsubj|accumulation accumulation|amod|END_ENTITY	Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon_cancer cells by regulation of glycogen_synthase_kinase-3beta activity .
20623542	0	glycogen_synthase_kinase-3beta	41,71	beta-catenin	104,116	glycogen synthase kinase-3beta	beta-catenin	84027(Tax:10116)	84353(Tax:10116)	Gene	Gene	complex|amod|START_ENTITY complex|acl:relcl|promotes promotes|dobj|turnover turnover|amod|END_ENTITY	Delta-catenin/NPRAP : A new member of the glycogen_synthase_kinase-3beta signaling complex that promotes beta-catenin turnover in neurons .
12228224	0	glycogen_synthase_kinase-3beta	16,46	caspase-3	87,96	glycogen synthase kinase-3beta	caspase-3	2932	836	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Central role of glycogen_synthase_kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation .
16371352	0	glycogen_synthase_kinase-3beta	47,77	cyclooxygenase-2	14,30	glycogen synthase kinase-3beta	cyclooxygenase-2	2932	5743	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 is regulated by glycogen_synthase_kinase-3beta in gastric_cancer cells .
9565682	0	glycogen_synthase_kinase-3beta	43,73	p23	115,118	glycogen synthase kinase-3beta	p23	2932	8851	Gene	Gene	activator|amod|START_ENTITY activator|appos|END_ENTITY	Characterization of tau phosphorylation in glycogen_synthase_kinase-3beta and cyclin dependent kinase-5 activator -LRB- p23 -RRB- transfected cells .
20470771	0	glycogen_synthase_kinase-3beta	143,173	p38	105,108	glycogen synthase kinase-3beta	p38	790875(Tax:9913)	534492(Tax:9913)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Nav1.7-Ca2 + influx-induced increased phosphorylations of extracellular signal-regulated kinase -LRB- ERK -RRB- and p38 attenuate tau phosphorylation via glycogen_synthase_kinase-3beta : priming of Nav1 .7 gating by ERK and p38 .
11104755	0	glycogen_synthase_kinase-3beta	18,48	presenilin_1	73,85	glycogen synthase kinase-3beta	presenilin 1	2932	5663	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Substitution of a glycogen_synthase_kinase-3beta phosphorylation site in presenilin_1 separates presenilin function from beta-catenin signaling .
16601113	0	glycogen_synthase_kinase-3beta	33,63	tumor_necrosis_factor-alpha	85,112	glycogen synthase kinase-3beta	tumor necrosis factor-alpha	56637(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Novel anti-inflammatory role for glycogen_synthase_kinase-3beta in the inhibition of tumor_necrosis_factor-alpha - and interleukin-1beta-induced inflammatory gene expression .
10958669	0	glycogen_synthase_kinase_3	6,32	Bul1	88,92	glycogen synthase kinase 3	Bul1	855170(Tax:4932)	855318(Tax:4932)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Yeast glycogen_synthase_kinase_3 is involved in protein degradation in cooperation with Bul1 , Bul2 , and Rsp5 .
17018141	0	glycogen_synthase_kinase_3_beta	8,39	GSK3beta	41,49	glycogen synthase kinase 3 beta	GSK3beta	2932	2932	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of glycogen_synthase_kinase_3_beta -LRB- GSK3beta -RRB- in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin_A -LRB- TSA -RRB- in MCF-7_breast_cancer cells .
23358925	0	glycogen_synthase_kinase_3a	26,53	GSK-3a	55,61	glycogen synthase kinase 3a	GSK-3a	2931	2931	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of porcine glycogen_synthase_kinase_3a -LRB- GSK-3a -RRB- gene and its association with carcass traits .
26683595	0	glycogen_synthase_kinase_3b	62,89	Aspartate_b-hydroxylase	0,23	glycogen synthase kinase 3b	Aspartate b-hydroxylase	2932	444	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Aspartate_b-hydroxylase modulates cellular senescence through glycogen_synthase_kinase_3b in hepatocellular_carcinoma .
22792253	0	glycogen_synthase_kinase_3b	36,63	GSK-3b	65,71	glycogen synthase kinase 3b	GSK-3b	100126852(Tax:9823)	100126852(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative splicing of the porcine glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- gene with differential expression patterns and regulatory functions .
25151579	0	glycogen_synthase_kinase_3b	148,175	GSK-3b	177,183	glycogen synthase kinase 3b	GSK-3b	2932	2932	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Design , synthesis and biological evaluation of N-alkyl_or_aryl_substituted_isoindigo derivatives as potential dual cyclin-dependent_kinase_2 -LRB- CDK2 -RRB- / glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- phosphorylation inhibitors .
26067173	0	glycogen_synthase_kinase_3b	49,76	GSK-3b	78,84	glycogen synthase kinase 3b	GSK-3b	56637(Tax:10090)	56637(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Radiosynthesis and preliminary PET evaluation of glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- inhibitors containing -LSB- -LRB- 11 -RRB- C -RSB- methylsulfanyl , -LSB- -LRB- 11 -RRB- C -RSB- methylsulfinyl or -LSB- -LRB- 11 -RRB- C -RSB- methylsulfonyl groups .
26185016	0	glycogen_synthase_kinase_3b	27,54	RBMY	0,4	glycogen synthase kinase 3b	RBMY	2932	5940	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	RBMY , a novel inhibitor of glycogen_synthase_kinase_3b , increases tumor stemness and predicts poor prognosis of hepatocellular_carcinoma .
22010210	0	glycogen_synthase_kinase_3b	95,122	b-catenin	123,132	glycogen synthase kinase 3b	b-catenin	2932	1499	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Impaired wound healing in hypoxic renal tubular cells : roles of hypoxia-inducible factor-1 and glycogen_synthase_kinase_3b / b-catenin signaling .
26184774	0	glycogen_synthase_kinase_3b	114,141	cyclin_E	172,180	glycogen synthase kinase 3b	cyclin E	84027(Tax:10116)	25729(Tax:10116)	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen_synthase_kinase_3b and subsequent degradation of cyclin_E in rats .
9566905	0	glycogen_synthase_kinase_3beta	55,85	Axil	0,4	glycogen synthase kinase 3beta	Axil	399097(Tax:8355)	447702(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Axil , a member of the Axin family , interacts with both glycogen_synthase_kinase_3beta and beta-catenin and inhibits axis formation of Xenopus embryos .
12421363	0	glycogen_synthase_kinase_3beta	47,77	Axin	0,4	glycogen synthase kinase 3beta	Axin	2932	8312	Gene	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	Axin negatively affects tau phosphorylation by glycogen_synthase_kinase_3beta .
17919914	0	glycogen_synthase_kinase_3beta	20,50	GSK-3beta	52,61	glycogen synthase kinase 3beta	GSK-3beta	2932	2932	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Non-ATP competitive glycogen_synthase_kinase_3beta -LRB- GSK-3beta -RRB- inhibitors : study of structural requirements for thiadiazolidinone derivatives .
17046157	0	glycogen_synthase_kinase_3beta	23,53	GSK3beta	55,63	glycogen synthase kinase 3beta	GSK3beta	84027(Tax:10116)	84027(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Age-related changes in glycogen_synthase_kinase_3beta -LRB- GSK3beta -RRB- immunoreactivity in the central nervous system of rats .
17241872	0	glycogen_synthase_kinase_3beta	54,84	Hath1	24,29	glycogen synthase kinase 3beta	Hath1	2932	474	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen_synthase_kinase_3beta in human colon_cancer .
11739659	0	glycogen_synthase_kinase_3beta	53,83	Microtubule-associated_protein_1B	0,33	glycogen synthase kinase 3beta	Microtubule-associated protein 1B	84027(Tax:10116)	29456(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Microtubule-associated_protein_1B phosphorylation by glycogen_synthase_kinase_3beta is induced during PC12 cell differentiation .
11004522	0	glycogen_synthase_kinase_3beta	85,115	ninein	46,52	glycogen synthase kinase 3beta	ninein	2932	51199	Gene	Gene	interacts|nmod|START_ENTITY protein|acl:relcl|interacts protein|compound|END_ENTITY	Cloning and characterization of a novel human ninein protein that interacts with the glycogen_synthase_kinase_3beta .
18261224	0	glycolipid_transfer_protein	6,33	GLTP	35,39	glycolipid transfer protein	GLTP	51228	51228	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Human glycolipid_transfer_protein -LRB- GLTP -RRB- genes : organization , transcriptional status and evolution .
20974858	0	glycolipid_transfer_protein	6,33	GLTP	40,44	glycolipid transfer protein	GLTP	51228	51228	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human glycolipid_transfer_protein gene -LRB- GLTP -RRB- expression is regulated by Sp1 and Sp3 : involvement of the bioactive sphingolipid_ceramide .
19665998	0	glycolipid_transfer_protein	4,31	VAP-A	106,111	glycolipid transfer protein	VAP-A	51228	9218	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The glycolipid_transfer_protein interacts with the vesicle-associated membrane protein-associated protein VAP-A .
1693779	0	glycoprotein	53,65	catalase	78,86	glycoprotein	catalase	7306	847	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Murine and human b locus pigmentation genes encode a glycoprotein -LRB- gp75 -RRB- with catalase activity .
1602536	0	glycoprotein	137,149	glycoprotein	18,30	glycoprotein	glycoprotein	155971(Tax:11676)	155971(Tax:11676)	Gene	Gene	absence|nmod|START_ENTITY induces|nmod|absence induces|nsubj|END_ENTITY	The transmembrane glycoprotein of human_immunodeficiency_virus_type_1 induces syncytium formation in the absence of the receptor binding glycoprotein .
1602536	0	glycoprotein	18,30	glycoprotein	137,149	glycoprotein	glycoprotein	155971(Tax:11676)	155971(Tax:11676)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|absence absence|nmod|END_ENTITY	The transmembrane glycoprotein of human_immunodeficiency_virus_type_1 induces syncytium formation in the absence of the receptor binding glycoprotein .
19919903	0	glycoprotein_2	86,100	GP2	102,105	glycoprotein 2	GP2	2813	2813	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The c. 1275A > G putative chronic pancreatitis-associated synonymous polymorphism in the glycoprotein_2 -LRB- GP2 -RRB- gene decreases exon 9 inclusion .
8244399	0	glycoprotein_330	15,31	Gp330	33,38	glycoprotein 330	Gp330	14725(Tax:10090)	14725(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the glycoprotein_330 -LRB- Gp330 -RRB- gene to mouse chromosome 2 .
7544804	0	glycoprotein_330	25,41	megalin	42,49	glycoprotein 330	megalin	4036	4036	Gene	Gene	START_ENTITY|parataxis|mediates mediates|nsubj|END_ENTITY	Evidence that epithelial glycoprotein_330 / megalin mediates uptake of polybasic drugs .
12368332	0	glycoprotein_D	53,67	HVEM	125,129	glycoprotein D	HVEM	2532	8764	Gene	Gene	START_ENTITY|dobj|site site|appos|END_ENTITY	Structure-based analysis of the herpes_simplex_virus glycoprotein_D binding site present on herpesvirus entry mediator HveA -LRB- HVEM -RRB- .
24314649	0	glycoprotein_D	78,92	HVEM	109,113	glycoprotein D	HVEM	2532	8764	Gene	Gene	START_ENTITY|advcl|binding binding|nmod|END_ENTITY	Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein_D upon binding to HVEM and nectin-1 .
9557640	0	glycoprotein_D	70,84	HVEM	106,110	glycoprotein D	HVEM	2532	8764	Gene	Gene	START_ENTITY|ccomp|block block|xcomp|binding binding|nmod|END_ENTITY	Monoclonal antibodies to distinct sites on herpes_simplex_virus -LRB- HSV -RRB- glycoprotein_D block HSV binding to HVEM .
18076965	0	glycoprotein_D	90,104	nectin-1	34,42	glycoprotein D	nectin-1	13349(Tax:10090)	58235(Tax:10090)	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|END_ENTITY	The herpes_simplex_virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein_D .
11090177	0	glycoprotein_D	104,118	nectin-1alpha	30,43	glycoprotein D	nectin-1alpha	2532	58235(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Striking similarity of murine nectin-1alpha to human nectin-1alpha -LRB- HveC -RRB- in sequence and activity as a glycoprotein_D receptor for alphaherpesvirus entry .
11090177	0	glycoprotein_D	104,118	nectin-1alpha	53,66	glycoprotein D	nectin-1alpha	2532	58235(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY nectin-1alpha|nmod|receptor nectin-1alpha|nmod|END_ENTITY	Striking similarity of murine nectin-1alpha to human nectin-1alpha -LRB- HveC -RRB- in sequence and activity as a glycoprotein_D receptor for alphaherpesvirus entry .
9241754	0	glycoprotein_IIIa	46,63	GPIIIa	65,71	glycoprotein IIIa	GPIIIa	3690	3690	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The Leu33/Pro polymorphism -LRB- PlA1/PlA2 -RRB- of the glycoprotein_IIIa -LRB- GPIIIa -RRB- receptor is not related to myocardial_infarction in the ECTIM Study .
22880801	0	glycoprotein_IIb	9,25	HPA-3	26,31	glycoprotein IIb	HPA-3	3674	3674	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Platelet glycoprotein_IIb HPA-3 a/b polymorphism is associated with native arteriovenous fistula thrombosis in chronic hemodialysis patients .
1715582	0	glycoprotein_IV	9,24	Fyn	66,69	glycoprotein IV	Fyn	948	2534	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Membrane glycoprotein_IV -LRB- CD36 -RRB- is physically associated with the Fyn , Lyn , and Yes protein-tyrosine kinases in human platelets .
11604562	0	glycoprotein_Ia	40,55	platelet_collagen_receptor	12,38	glycoprotein Ia	platelet collagen receptor	22915	51206	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of platelet_collagen_receptor -LRB- glycoprotein_Ia / IIa ; integrin alpha2 beta1 -RRB- polymorphisms in thrombotic_disease .
21602602	0	glycoprotein_Iba	52,68	C-reactive_protein	9,27	glycoprotein Iba	C-reactive protein	2811	1401	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Modified C-reactive_protein interacts with platelet glycoprotein_Iba .
11514372	0	glycoprotein_Ibalpha	9,29	HPA-2	30,35	glycoprotein Ibalpha	HPA-2	2811	60495	Gene	Gene	B|compound|START_ENTITY B|compound|END_ENTITY	Platelet glycoprotein_Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial_infarction and sudden_cardiac_death .
15317813	0	glycoprotein_Ibalpha	37,57	factor_XI	83,92	glycoprotein Ibalpha	factor XI	2811	2160	Gene	Gene	site|nmod|START_ENTITY Identification|nmod|site Identification|nmod|END_ENTITY	Identification of a binding site for glycoprotein_Ibalpha in the Apple 3 domain of factor_XI .
24325877	0	glycoprotein_VI	43,58	GPVI	60,64	glycoprotein VI	GPVI	51206	51206	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated plasma levels of soluble platelet glycoprotein_VI -LRB- GPVI -RRB- in patients with thrombotic_microangiopathy .
14629478	0	glycoprotein_VI	50,65	c-Cbl	0,5	glycoprotein VI	c-Cbl	243816(Tax:10090)	12402(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	c-Cbl negatively regulates platelet activation by glycoprotein_VI .
12049640	0	glycoprotein_VI	61,76	phospholipase_Cgamma2	100,121	glycoprotein VI	phospholipase Cgamma2	51206	5336	Gene	Gene	regulation|amod|START_ENTITY regulation|amod|END_ENTITY	Differential role of glycolipid-enriched membrane domains in glycoprotein_VI - and integrin-mediated phospholipase_Cgamma2 regulation in platelets .
16113793	0	glycoprotein_VI	78,93	thrombin	54,62	glycoprotein VI	thrombin	51206	2147	Gene	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Fibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein_VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin .
25663982	0	glycoprotein_non-metastatic_melanoma_protein_B	27,73	GPNMB	75,80	glycoprotein non-metastatic melanoma protein B	GPNMB	10457	10457	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of glycoprotein_non-metastatic_melanoma_protein_B -LRB- GPNMB -RRB- involved in trichostatin_A-induced apoptosis in gastric_cancer .
26077887	0	glycoprotein_nonmetastatic_B	25,53	HER2	79,83	glycoprotein nonmetastatic B	HER2	10457	2064	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of glycoprotein_nonmetastatic_B and its association with HER2 in breast_cancer .
23924854	0	glycoprotein_nonmetastatic_B	16,44	colony-stimulating_factor-1	48,75	glycoprotein nonmetastatic B	colony-stimulating factor-1	10457	1435	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of glycoprotein_nonmetastatic_B by colony-stimulating_factor-1 and epithelial_cell_adhesion_molecule in hepatocellular_carcinoma cells .
24682924	0	glycoprotein_nonmetastatic_melanoma_B	124,161	GPNMB	163,168	glycoprotein nonmetastatic melanoma B	GPNMB	10457	10457	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Induction of matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in the microglia by lipopolysaccharide -LRB- LPS -RRB- via upregulation of glycoprotein_nonmetastatic_melanoma_B -LRB- GPNMB -RRB- expression .
11337258	0	glycosylation-dependent_cell_adhesion_molecule_1	14,62	GlyCAM-1	64,72	glycosylation-dependent cell adhesion molecule 1	GlyCAM-1	14663(Tax:10090)	14663(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of glycosylation-dependent_cell_adhesion_molecule_1 -LRB- GlyCAM-1 -RRB- gene in the mouse mammary gland differs from that of casein genes .
21478160	0	glycosylphosphatidylinositol-anchored_high_density_lipoprotein-binding_protein_1	26,106	GPIHBP1	108,115	glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1	GPIHBP1	100759460	100759460	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Assessing the role of the glycosylphosphatidylinositol-anchored_high_density_lipoprotein-binding_protein_1 -LRB- GPIHBP1 -RRB- three-finger domain in binding lipoprotein_lipase .
7908190	0	glycosylphosphatidylinositol-specific_phospholipase_D	64,117	Thy-1	49,54	glycosylphosphatidylinositol-specific phospholipase D	Thy-1	14756(Tax:10090)	21838(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|release release|nmod|END_ENTITY	Saponin-induced release of cell-surface-anchored Thy-1 by serum glycosylphosphatidylinositol-specific_phospholipase_D .
11072085	0	glycosylphosphatidylinositol_phospholipase_D1	38,83	GPLD1	85,90	glycosylphosphatidylinositol phospholipase D1	GPLD1	2822	2822	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and expression of the human glycosylphosphatidylinositol_phospholipase_D1 -LRB- GPLD1 -RRB- gene .
24619417	0	glycosyltransferase_N-acetylglucosaminyltransferase-IX	42,96	GnT-IX	98,104	glycosyltransferase N-acetylglucosaminyltransferase-IX	GnT-IX	268510(Tax:10090)	268510(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Epigenetic regulation of a brain-specific glycosyltransferase_N-acetylglucosaminyltransferase-IX -LRB- GnT-IX -RRB- by specific chromatin modifiers .
19412816	0	glycyl-tRNA_synthetase	23,45	GARS	47,51	glycyl-tRNA synthetase	GARS	2617	2617	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of glycyl-tRNA_synthetase -LRB- GARS -RRB- gene in Hirayama_disease .
26000875	0	glycyl-tRNA_synthetase	24,46	GARS	48,52	glycyl-tRNA synthetase	GARS	2617	2617	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation of the glycyl-tRNA_synthetase -LRB- GARS -RRB- gene associated with Charcot-Marie-Tooth_type_2D in a Chinese family .
986362	0	glyoxalase_I	27,39	GLO	41,44	glyoxalase I	GLO	2739	2739	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible assignment of the glyoxalase_I -LRB- GLO -RRB- gene to chromosome 6 using man-mouse somatic cell hybrids .
3947646	0	glyoxalase_I	24,36	lactoylglutathione_lyase	38,62	glyoxalase I	lactoylglutathione lyase	2739	2739	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of mammalian glyoxalase_I -LRB- lactoylglutathione_lyase -RRB- by N-acylated_S-blocked_glutathione derivatives as a probe for the role of the N-site of glutathione in glyoxalase_I mechanism .
14635115	0	glyoxylate_reductase	26,46	GRHPR	48,53	glyoxylate reductase	GRHPR	9380	9380	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Molecular analysis of the glyoxylate_reductase -LRB- GRHPR -RRB- gene and description of mutations underlying primary hyperoxaluria_type_2 .
15840574	0	glyoxylate_reductase	73,93	hydroxypyruvate_reductase	94,119	glyoxylate reductase	hydroxypyruvate reductase	9380	9380	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate_reductase / hydroxypyruvate_reductase gene by the peroxisome_proliferator-activated_receptor_alpha .
10964473	0	glypican-3	0,10	Bmp4	42,46	glypican-3	Bmp4	14734(Tax:10090)	12159(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development .
18785116	0	glypican-3	22,32	GPC3	34,38	glypican-3	GPC3	2719	2719	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of glypican-3 -LRB- GPC3 -RRB- during human embryonic and fetal development .
26345955	0	glypican-3	27,37	GPC3	39,43	glypican-3	GPC3	2719	2719	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of glypican-3 -LRB- GPC3 -RRB- in lung_squamous_cell_carcinoma and lung_adenocarcinoma and its clinical significance .
26345955	0	glypican-3	27,37	GPC3	39,43	glypican-3	GPC3	2719	2719	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of glypican-3 -LRB- GPC3 -RRB- in lung_squamous_cell_carcinoma and lung_adenocarcinoma and its clinical significance .
25624497	0	glypican-4	50,60	LRRTM4	61,67	glypican-4	LRRTM4	317322(Tax:10116)	500219(Tax:10116)	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	PTP functions as a presynaptic receptor for the glypican-4 / LRRTM4 complex and is essential for excitatory synaptic transmission .
9070915	0	glypican-5	20,30	GPC5	69,73	glypican-5	GPC5	2262	2262	Gene	Gene	localization|amod|START_ENTITY localization|nmod|END_ENTITY	Characterization of glypican-5 and chromosomal localization of human GPC5 , a new member of the glypican gene family .
11008203	0	glypican_3	14,24	GPC3	26,30	glypican 3	GPC3	2719	2719	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of glypican_3 -LRB- GPC3 -RRB- in embryonal_tumors .
15372512	0	glypican_3	55,65	GPC3	67,71	glypican 3	GPC3	2719	2719	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the tumor suppressor PTEN and the glypican_3 -LRB- GPC3 -RRB- gene in patients diagnosed with Proteus_syndrome .
9339360	0	glypican_3	127,137	GPC3	139,143	glypican 3	GPC3	2719	2719	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5 ' - promoter and 3 ' - terminal ends of the human glypican_3 -LRB- GPC3 -RRB- gene .
9651473	0	glypican_3	90,100	GPC3	102,106	glypican 3	GPC3	2719	2719	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican_3 -LRB- GPC3 -RRB- gene .
9281346	0	glypican_3	20,30	OCI-5	14,19	glypican 3	OCI-5	25236(Tax:10116)	25236(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of OCI-5 / glypican_3 during intestinal morphogenesis : regulation by cell shape in intestinal epithelial cells .
18318435	0	glypican_3	25,35	Sulfatase_2	0,11	glypican 3	Sulfatase 2	2719	55959	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Sulfatase_2 up-regulates glypican_3 , promotes fibroblast growth factor signaling , and decreases survival_in_hepatocellular_carcinoma .
17668883	0	glypican_3	19,29	zinc_fingers_and_homeoboxes_2	69,98	glypican 3	zinc fingers and homeoboxes 2	14734(Tax:10090)	387609(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The oncofetal gene glypican_3 is regulated in the postnatal liver by zinc_fingers_and_homeoboxes_2 and in the regenerating liver by alpha-fetoprotein_regulator_2 .
21597760	0	gm-csf	18,24	Tnf-alpha	0,9	gm-csf	Tnf-alpha	1437	7124	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Tnf-alpha induces gm-csf secretion in leukemic-cell lines u-937 and kg-1a .
10630413	0	gnRH	73,77	gonadotropin-releasing_hormone	41,71	gnRH	gonadotropin-releasing hormone	2796	2796	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Estrogen_receptor-mediated repression of gonadotropin-releasing_hormone -LRB- gnRH -RRB- promoter activity in transfected CHO-K1 cells .
25475593	0	gnrh2	63,68	gonadotropin_releasing_hormone	31,61	gnrh2	gonadotropin releasing hormone	2797	2796	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Brain aromatase -LRB- cyp19a1b -RRB- and gonadotropin_releasing_hormone -LRB- gnrh2 and gnrh3 -RRB- expression during reproductive development and sex change in black sea bass -LRB- Centropristis striata -RRB- .
15730785	0	gob-5	34,39	interleukin-13	12,26	gob-5	interleukin-13	23844(Tax:10090)	16163(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of interleukin-13 on the gob-5 and MUC5AC expression in lungs of a murine asthmatic model -RSB- .
15951434	0	golgin-160	32,42	PIST	77,81	golgin-160	PIST	2802	57120	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	Isoform-specific interaction of golgin-160 with the Golgi-associated protein PIST .
20601164	0	gonadal_soma_derived_factor	14,41	GSDF	43,47	gonadal soma derived factor	GSDF	100415911	100415911	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of gonadal_soma_derived_factor -LRB- GSDF -RRB- is spatially and temporally correlated with early testicular differentiation in medaka .
20812005	0	gonadotrophin-releasing_hormone	39,70	ERK	85,88	gonadotrophin-releasing hormone	ERK	2796	5594	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Using high-content microscopy to study gonadotrophin-releasing_hormone regulation of ERK .
322999	0	gonadotrophin-releasing_hormone	11,42	Gn-RH	44,49	gonadotrophin-releasing hormone	Gn-RH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of gonadotrophin-releasing_hormone -LRB- Gn-RH -RRB- from isolated , perifused medial-basal hypothalamus by melatonin .
10848876	0	gonadotrophin-releasing_hormone	10,41	GnRH	43,47	gonadotrophin-releasing hormone	GnRH	2796	2796	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- antagonist during the LH surge in normal women and during controlled ovarian_hyperstimulation .
18563864	0	gonadotrophin-releasing_hormone	36,67	GnRH	69,73	gonadotrophin-releasing hormone	GnRH	2796	2796	Gene	Gene	determination|nmod|START_ENTITY determination|appos|END_ENTITY	Mass spectrometric determination of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- in human urine for doping control purposes by means of LC-ESI-MS/MS .
20814074	0	gonadotrophin-releasing_hormone	81,112	GnRH	114,118	gonadotrophin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Vasopressin release from the rat hypothalamo-neurohypophysial system : effects of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- , its analogues and melatonin .
16101891	0	gonadotrophin-releasing_hormone	45,76	calcitonin_gene-related_peptide	10,41	gonadotrophin-releasing hormone	calcitonin gene-related peptide	2796	796	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of calcitonin_gene-related_peptide on gonadotrophin-releasing_hormone mRNA expression in GT1-7 cells .
21791179	0	gonadotrophin-releasing_hormone	88,119	corticotropin-releasing_hormone	11,42	gonadotrophin-releasing hormone	corticotropin-releasing hormone	2796	1392	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_hormone and its antagonist on the gene expression of gonadotrophin-releasing_hormone -LRB- GnRH -RRB- and GnRH_receptor in the hypothalamus and anterior pituitary gland of follicular phase ewes .
25729962	0	gonadotropin-inhibitory_hormone	69,100	GnIH	102,106	gonadotropin-inhibitory hormone	GnIH	378785(Tax:9031)	378785(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and association of single-nucleotide polymorphisms in gonadotropin-inhibitory_hormone -LRB- GnIH -RRB- gene with egg production traits in Erlang mountainous chickens .
16469493	0	gonadotropin-regulated_long_chain_acyl-CoA_synthetase	48,101	GR-LACS	103,110	gonadotropin-regulated long chain acyl-CoA synthetase	GR-LACS	171410(Tax:10116)	171410(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Tissue-cell - and species-specific expression of gonadotropin-regulated_long_chain_acyl-CoA_synthetase -LRB- GR-LACS -RRB- in gonads , adrenal and brain .
6815258	0	gonadotropin-releasing-hormone	93,123	Gn-RH	125,130	gonadotropin-releasing-hormone	Gn-RH	2796	2796	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Induction of ovulation and pregnancy resulting from chronic and pulsatile administration of gonadotropin-releasing-hormone -LRB- Gn-RH -RRB- -RSB- .
9518872	0	gonadotropin-releasing_hormone	34,64	Activin-A	0,9	gonadotropin-releasing hormone	Activin-A	25194(Tax:10116)	29200(Tax:10116)	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Activin-A stimulates hypothalamic gonadotropin-releasing_hormone release by the explanted male rat hypothalamus : interaction with inhibin and androgens .
3524753	0	gonadotropin-releasing_hormone	46,76	Corticotropin-releasing_factor	0,30	gonadotropin-releasing hormone	Corticotropin-releasing factor	25194(Tax:10116)	81648(Tax:10116)	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Corticotropin-releasing_factor -LRB- CRF -RRB- inhibits gonadotropin-releasing_hormone -LRB- GnRH -RRB- release from superfused rat hypothalami in vitro .
11083862	0	gonadotropin-releasing_hormone	84,114	ERK	77,80	gonadotropin-releasing hormone	ERK	2796	5594	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|activation activation|nmod|END_ENTITY	Role of dynamin , Src , and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing_hormone .
22186412	0	gonadotropin-releasing_hormone	46,76	ERK	0,3	gonadotropin-releasing hormone	ERK	14714(Tax:10090)	26413(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|signaling signaling|compound|END_ENTITY	ERK signaling , but not c-Raf , is required for gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced regulation of Nur77 in pituitary gonadotropes .
10537130	0	gonadotropin-releasing_hormone	29,59	ERalpha	111,118	gonadotropin-releasing hormone	ERalpha	25194(Tax:10116)	24890(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
19533841	0	gonadotropin-releasing_hormone	31,61	Follistatin	0,11	gonadotropin-releasing hormone	Follistatin	2796	10468	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Follistatin gene expression by gonadotropin-releasing_hormone : a role for cyclic_AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph LbetaT2 cells .
11344181	0	gonadotropin-releasing_hormone	28,58	GH	106,108	gonadotropin-releasing hormone	GH	2796	2688	Gene	Gene	agonist|amod|START_ENTITY administering|dobj|agonist administering|nmod|growth_hormone growth_hormone|appos|END_ENTITY	The effect of administering gonadotropin-releasing_hormone agonist with recombinant-human growth_hormone -LRB- GH -RRB- on the final height of girls with isolated_GH_deficiency : results from a controlled study .
12629103	0	gonadotropin-releasing_hormone	83,113	GH	25,27	gonadotropin-releasing hormone	GH	2796	2688	Gene	Gene	analogs|amod|START_ENTITY therapy|nmod|analogs benefit|nmod|therapy benefit|nsubj|END_ENTITY	Can some growth_hormone -LRB- GH -RRB- - deficient children benefit from combined therapy with gonadotropin-releasing_hormone analogs and GH ?
12955021	0	gonadotropin-releasing_hormone	41,71	GH	100,102	gonadotropin-releasing hormone	GH	2796	2688	Gene	Gene	agonists|amod|START_ENTITY addition|nmod|agonists experience|nmod|addition experience|nmod|treatment treatment|appos|END_ENTITY	The KIGS experience with the addition of gonadotropin-releasing_hormone agonists to growth_hormone -LRB- GH -RRB- treatment of children with idiopathic_GH_deficiency .
16787696	0	gonadotropin-releasing_hormone	34,64	GH	103,105	gonadotropin-releasing hormone	GH	2796	2688	Gene	Gene	agonists|amod|START_ENTITY agonists|nmod|treatment treatment|appos|END_ENTITY	A brief review of the addition of gonadotropin-releasing_hormone agonists -LRB- GnRH-Ag -RRB- to growth_hormone -LRB- GH -RRB- treatment of children with idiopathic growth_hormone deficiency : Previously published studies from America .
3143542	0	gonadotropin-releasing_hormone	61,91	GH	236,238	gonadotropin-releasing hormone	GH	2796	2688	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Endogenous human growth_hormone -LRB- GH -RRB- modulates the effect of gonadotropin-releasing_hormone on pituitary function and the gonadotropin response to the negative feedback effect of testosterone in adult male transgenic_mice bearing human GH gene .
3143542	0	gonadotropin-releasing_hormone	61,91	GH	33,35	gonadotropin-releasing hormone	GH	2796	2688	Gene	Gene	gene|amod|START_ENTITY effect|nmod|gene modulates|dobj|effect modulates|nsubj|growth_hormone growth_hormone|appos|END_ENTITY	Endogenous human growth_hormone -LRB- GH -RRB- modulates the effect of gonadotropin-releasing_hormone on pituitary function and the gonadotropin response to the negative feedback effect of testosterone in adult male transgenic_mice bearing human GH gene .
10677547	0	gonadotropin-releasing_hormone	56,86	GT1	100,103	gonadotropin-releasing hormone	GT1	2796	2683	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|cells cells|nummod|END_ENTITY	Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing_hormone secretion in GT1 cells .
15665093	0	gonadotropin-releasing_hormone	31,61	G_protein-coupled_receptor_54	74,103	gonadotropin-releasing hormone	G protein-coupled receptor 54	14714(Tax:10090)	114229(Tax:10090)	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Kisspeptin directly stimulates gonadotropin-releasing_hormone release via G_protein-coupled_receptor_54 .
6754523	0	gonadotropin-releasing_hormone	26,56	Gn-RH	58,63	gonadotropin-releasing hormone	Gn-RH	2796	2796	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Pulsatile treatment with gonadotropin-releasing_hormone -LRB- Gn-RH -RRB- -RSB- .
10513982	1	gonadotropin-releasing_hormone	83,113	GnRH	115,119	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation with gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist-induced apoptosis in the corpus luteum .
10537130	0	gonadotropin-releasing_hormone	29,59	GnRH	61,65	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Estrogen directly respresses gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression in estrogen receptor-alpha -LRB- ERalpha -RRB- - and ERbeta-expressing GT1-7 GnRH neurons .
10551782	0	gonadotropin-releasing_hormone	47,77	GnRH	79,83	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Enhanced splicing of the first intron from the gonadotropin-releasing_hormone -LRB- GnRH -RRB- primary transcript is a prerequisite for mature GnRH messenger RNA : presence of GnRH neuron-specific splicing factors .
1097462	0	gonadotropin-releasing_hormone	20,50	GnRH	52,56	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of synthetic gonadotropin-releasing_hormone -LRB- GnRH -RRB- in a patient with the `` fertile_eunuch '' _ syndrome .
11223187	0	gonadotropin-releasing_hormone	51,81	GnRH	83,87	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of exonic splicing enhancers in the mouse gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene .
11245923	0	gonadotropin-releasing_hormone	100,130	GnRH	132,136	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A functional retinoic_acid response element -LRB- RARE -RRB- is present within the distal promoter of the rat gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene .
11245924	0	gonadotropin-releasing_hormone	51,81	GnRH	83,87	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	9-cis-Retinoic_acid represses transcription of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene via proximal promoter region that is distinct from all-trans-retinoic_acid response element .
11255560	0	gonadotropin-releasing_hormone	62,92	GnRH	94,98	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Progress towards the development of non-peptide orally-active gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists : therapeutic implications .
11307033	0	gonadotropin-releasing_hormone	14,44	GnRH	46,50	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression during GnRH neuron migration in the mouse .
11312152	0	gonadotropin-releasing_hormone	22,52	GnRH	54,58	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Autoregulation of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- system during puberty : effects of antagonistic versus agonistic GnRH analogs in a female rat model .
12065890	0	gonadotropin-releasing_hormone	89,119	GnRH	138,142	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	A role for hypothalamic astrocytes in dehydroepiandrosterone and estradiol regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by GnRH neurons .
12639969	0	gonadotropin-releasing_hormone	38,68	GnRH	70,74	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Excision of the first intron from the gonadotropin-releasing_hormone -LRB- GnRH -RRB- transcript serves as a key regulatory step for GnRH biosynthesis .
12865313	0	gonadotropin-releasing_hormone	55,85	GnRH	87,91	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sex differences in estrogen-dependent transcription of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene revealed in GnRH transgenic_mice .
12865349	0	gonadotropin-releasing_hormone	31,61	GnRH	63,67	gonadotropin-releasing hormone	GnRH	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Seasonal plasticity within the gonadotropin-releasing_hormone -LRB- GnRH -RRB- system of the ewe : changes in identified GnRH inputs and glial association .
1374022	0	gonadotropin-releasing_hormone	32,62	GnRH	64,68	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Partial characterization of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene transcript in the rat ovary .
14525953	0	gonadotropin-releasing_hormone	95,125	GnRH	127,131	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Position of Pro and Ser near Glu7 .32 in the extracellular loop 3 of mammalian and nonmammalian gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors is a critical determinant for differential ligand selectivity for mammalian GnRH and chicken GnRH-II .
14594454	0	gonadotropin-releasing_hormone	8,38	GnRH	40,44	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in ovarian_cancer .
15004428	0	gonadotropin-releasing_hormone	14,44	GnRH	46,50	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Repression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression by melatonin may involve transcription factors COUP-TFI and C/EBP _ beta binding at the GnRH enhancer .
16412770	0	gonadotropin-releasing_hormone	15,45	GnRH	47,51	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Treatment with gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists in women suppressed with GnRH agonist may avoid cycle cancellation in patients at risk for ovarian_hyperstimulation_syndrome .
1657576	0	gonadotropin-releasing_hormone	52,82	GnRH	84,88	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Protein_kinase-C activation stimulates synthesis of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors , but does not mediate GnRH-stimulated receptor synthesis .
16675899	0	gonadotropin-releasing_hormone	56,86	GnRH	88,92	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Photoperiod-independent changes in immunoreactive brain gonadotropin-releasing_hormone -LRB- GnRH -RRB- in a free-living , tropical bird .
16929534	0	gonadotropin-releasing_hormone	8,38	GnRH	40,44	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the regulation of gonadal differentiation in the gilthead seabream -LRB- Sparus aurata -RRB- .
17852411	0	gonadotropin-releasing_hormone	53,83	GnRH	85,89	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Controlled ovarian_hyperstimulation using multi-dose gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonist results in less systemic_inflammation than the GnRH-agonist long protocol .
18423456	0	gonadotropin-releasing_hormone	18,48	GnRH	50,54	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Pretreatment with gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists to prevent the flare-up effect of long-acting GnRH agonists : results of a pilot study .
19040620	0	gonadotropin-releasing_hormone	40,70	GnRH	72,76	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dihydrotestosterone and leptin regulate gonadotropin-releasing_hormone -LRB- GnRH -RRB- expression and secretion in human GnRH-secreting neuroblasts .
19856133	0	gonadotropin-releasing_hormone	27,57	GnRH	59,63	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in pancreas during rat pregnancy .
19861704	0	gonadotropin-releasing_hormone	14,44	GnRH	46,50	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptor-I expression in the pituitary and ovary by a GnRH agonist and antagonist .
21660456	0	gonadotropin-releasing_hormone	33,63	GnRH	65,69	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Histological characterization of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the hypothalamus of the South American plains vizcacha -LRB- Lagostomus maximus -RRB- .
21924414	0	gonadotropin-releasing_hormone	181,211	GnRH	213,217	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Is earlier administration of human chorionic gonadotropin -LRB- hCG -RRB- associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing_hormone -LRB- GnRH -RRB- antagonists ?
2274018	0	gonadotropin-releasing_hormone	26,56	GnRH	58,62	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Pulsatile treatment with gonadotropin-releasing_hormone -LRB- GnRH -RRB- -RSB- .
2500326	0	gonadotropin-releasing_hormone	151,181	GnRH	183,187	gonadotropin-releasing hormone	GnRH	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Bilateral orchidectomy and concomitant testosterone replacement in the juvenile male rhesus_monkey -LRB- Macaca_mulatta -RRB- receiving an invariant intravenous gonadotropin-releasing_hormone -LRB- GnRH -RRB- infusion results , as in the hypothalamus lesioned GnRH-driven adult male , in a selective hypersecretion of follicle-stimulating hormone .
2501122	0	gonadotropin-releasing_hormone	23,53	GnRH	55,59	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Simultaneous effect of gonadotropin-releasing_hormone -LRB- GnRH -RRB- on the expression of two gonadotropin beta genes by passive immunization to GnRH .
2513450	0	gonadotropin-releasing_hormone	18,48	GnRH	50,54	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Regulation of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal system : morphological aspects .
2546961	0	gonadotropin-releasing_hormone	24,54	GnRH	56,60	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Normal structure of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene in patients with GnRH_deficiency and idiopathic_hypogonadotropic_hypogonadism .
25516463	0	gonadotropin-releasing_hormone	47,77	GnRH	79,83	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Autoshortloop feedback regulation of pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion by its metabolite , GnRH - -LRB- 1-5 -RRB- .
2987065	0	gonadotropin-releasing_hormone	40,70	GnRH	72,76	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Newborn and immature rat testes contain gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors , and their testosterone production is stimulated by a GnRH agonist in vitro .
3098547	0	gonadotropin-releasing_hormone	31,61	GnRH	63,67	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Reevaluation of immunoreactive gonadotropin-releasing_hormone -LRB- GnRH -RRB- levels in general circulation in women : changes in levels and episodic patterns before , during and after gonadotropin surges .
322467	0	gonadotropin-releasing_hormone	36,66	GnRH	68,72	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the fetal and early postnatal mouse brain .
3287358	0	gonadotropin-releasing_hormone	24,54	GnRH	56,60	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Polygenic expression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in human ?
3539214	0	gonadotropin-releasing_hormone	61,91	GnRH	93,97	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Short photoperiod-induced gonadal_regression : effects on the gonadotropin-releasing_hormone -LRB- GnRH -RRB- neuronal system of the white-footed mouse , Peromyscus leucopus .
3920237	0	gonadotropin-releasing_hormone	20,50	GnRH	52,56	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Hormonal effects of gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist in the human male .
6363435	0	gonadotropin-releasing_hormone	24,54	GnRH	56,60	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of continuous gonadotropin-releasing_hormone -LRB- GnRH -RRB- agonist treatment on luteinizing hormone and testosterone secretion , the response to GnRH , and the testicular response to human chorionic gonadotropin in male rhesus_monkeys .
6369267	0	gonadotropin-releasing_hormone	27,57	GnRH	59,63	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Proteolytic degradation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- by rat ovarian fractions in vitro .
7013981	0	gonadotropin-releasing_hormone	36,66	GnRH	68,72	gonadotropin-releasing hormone	GnRH	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the brain and infundibulum of the sheep .
7858734	0	gonadotropin-releasing_hormone	22,52	GnRH	54,58	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Stimulatory effect of gonadotropin-releasing_hormone -LRB- GnRH -RRB- on in vitro prolactin secretion and presence of GnRH specific receptors in a subset of human prolactinomas .
8137746	0	gonadotropin-releasing_hormone	32,62	GnRH	64,68	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Central regulation of pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion by estradiol during the period leading up to the preovulatory GnRH surge in the ewe .
8187165	0	gonadotropin-releasing_hormone	11,41	GnRH	43,47	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of gonadotropin-releasing_hormone -LRB- GnRH -RRB- on the cytodifferentiation of gonadotropes in rat adenohypophysial primordia in organ culture .
8300908	0	gonadotropin-releasing_hormone	46,76	GnRH	78,82	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and morphology of immunoreactive gonadotropin-releasing_hormone -LRB- GnRH -RRB- neurons in the basal forebrain of ponies .
8405686	0	gonadotropin-releasing_hormone	72,102	GnRH	104,108	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Biochemical differentiation and intercellular interactions of migratory gonadotropin-releasing_hormone -LRB- GnRH -RRB- cells in the mouse .
8721988	0	gonadotropin-releasing_hormone	22,52	GnRH	54,58	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Steroid and pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- regulation of luteinizing hormone and GnRH_receptor in a novel gonadotrope cell line .
8732461	0	gonadotropin-releasing_hormone	26,56	GnRH	58,62	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Continuous stimulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- receptors by GnRH agonist decreases pituitary GnRH_receptor messenger ribonucleic_acid concentration in immature female rats .
9048632	0	gonadotropin-releasing_hormone	40,70	GnRH	72,76	gonadotropin-releasing hormone	GnRH	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Evidence for seasonal plasticity in the gonadotropin-releasing_hormone -LRB- GnRH -RRB- system of the ewe : changes in synaptic inputs onto GnRH neurons .
9121495	0	gonadotropin-releasing_hormone	32,62	GnRH	64,68	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Phorbol_ester regulation of the gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene in GnRH-secreting cell lines : a molecular basis for species differences .
9158062	0	gonadotropin-releasing_hormone	15,45	GnRH	47,51	gonadotropin-releasing hormone	GnRH	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	On the role of gonadotropin-releasing_hormone -LRB- GnRH -RRB- in the operation of the GnRH pulse generator in the rhesus_monkey .
9212061	0	gonadotropin-releasing_hormone	14,44	GnRH	46,50	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene expression by insulin-like_growth_factor_I in a cultured GnRH-expressing neuronal cell line .
9389763	0	gonadotropin-releasing_hormone	50,80	GnRH	82,86	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Cytochemical studies of the effects of activin on gonadotropin-releasing_hormone -LRB- GnRH -RRB- binding by pituitary gonadotropes and growth_hormone cells .
9406917	0	gonadotropin-releasing_hormone	37,67	GnRH	69,73	gonadotropin-releasing hormone	GnRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence for autocrine inhibition of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene transcription by GnRH in hypothalamic GT1-1 neuronal cells .
9435376	0	gonadotropin-releasing_hormone	57,87	GnRH	89,93	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Regulation of follicular luteinization by an agonist of gonadotropin-releasing_hormone -LRB- GnRH -RRB- -RSB- .
9528988	0	gonadotropin-releasing_hormone	30,60	GnRH	62,66	gonadotropin-releasing hormone	GnRH	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Neonatal immunization against gonadotropin-releasing_hormone -LRB- GnRH -RRB- results in diminished GnRH secretion in adulthood .
9556083	0	gonadotropin-releasing_hormone	58,88	GnRH	52,56	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	identification|dep|START_ENTITY identification|nmod|END_ENTITY	Chromatographic and immunological identification of GnRH -LRB- gonadotropin-releasing_hormone -RRB- variants .
9688346	0	gonadotropin-releasing_hormone	12,42	GnRH	44,48	gonadotropin-releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Presence of gonadotropin-releasing_hormone -LRB- GnRH -RRB- mRNA in Rathke 's pouch and effect of the GnRH-antagonist ORG_30276 on lactotroph development in vitro .
9739116	0	gonadotropin-releasing_hormone	12,42	GnRH	44,48	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increase in gonadotropin-releasing_hormone -LRB- GnRH -RRB- levels in CSF after stimulation of the nervus terminalis in Atlantic stingray , Dasyatis sabina .
9783851	0	gonadotropin-releasing_hormone	14,44	GnRH	46,50	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of gonadotropin-releasing_hormone -LRB- GnRH -RRB- gene in human uterine endometrial tissue .
9915990	0	gonadotropin-releasing_hormone	25,55	GnRH	57,61	gonadotropin-releasing hormone	GnRH	2796	2796	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Photoperiodic effects on gonadotropin-releasing_hormone -LRB- GnRH -RRB- content and the GnRH-immunoreactive neuronal system of male Siberian hamsters .
1819551	0	gonadotropin-releasing_hormone	25,55	Interleukin-6	0,13	gonadotropin-releasing hormone	Interleukin-6	25194(Tax:10116)	24498(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates gonadotropin-releasing_hormone secretion from rat hypothalamic cells .
15665093	0	gonadotropin-releasing_hormone	31,61	Kisspeptin	0,10	gonadotropin-releasing hormone	Kisspeptin	14714(Tax:10090)	280287(Tax:10090)	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Kisspeptin directly stimulates gonadotropin-releasing_hormone release via G_protein-coupled_receptor_54 .
18450966	0	gonadotropin-releasing_hormone	25,55	Kisspeptin	0,10	gonadotropin-releasing hormone	Kisspeptin	14714(Tax:10090)	280287(Tax:10090)	Gene	Gene	release|amod|START_ENTITY stimulate|dobj|release stimulate|nsubj|END_ENTITY	Kisspeptin can stimulate gonadotropin-releasing_hormone -LRB- GnRH -RRB- release by a direct action at GnRH nerve terminals .
22186412	0	gonadotropin-releasing_hormone	46,76	Nur77	106,111	gonadotropin-releasing hormone	Nur77	14714(Tax:10090)	15370(Tax:10090)	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	ERK signaling , but not c-Raf , is required for gonadotropin-releasing_hormone -LRB- GnRH -RRB- - induced regulation of Nur77 in pituitary gonadotropes .
3921411	0	gonadotropin-releasing_hormone	25,55	Prolactin	0,9	gonadotropin-releasing hormone	Prolactin	2796	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response after gonadotropin-releasing_hormone in the polycystic_ovary_syndrome .
10022430	0	gonadotropin-releasing_hormone	153,183	TIMP-3	108,114	gonadotropin-releasing hormone	TIMP-3	2796	7078	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Independent regulation of matrix_metalloproteinase-9 , tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- , and TIMP-3 in human endometrial stromal cells by gonadotropin-releasing_hormone : implications in early human implantation .
8793856	0	gonadotropin-releasing_hormone	100,130	c-jun	21,26	gonadotropin-releasing hormone	c-jun	2796	3725	Gene	Gene	stimulation|amod|START_ENTITY cDNAs|nmod|stimulation cDNAs|nsubj|cloning cloning|nmod|END_ENTITY	Molecular cloning of c-jun and c-fos cDNAs from porcine anterior pituitary and their involvement in gonadotropin-releasing_hormone stimulation .
10630413	0	gonadotropin-releasing_hormone	41,71	gnRH	73,77	gonadotropin-releasing hormone	gnRH	2796	2796	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Estrogen_receptor-mediated repression of gonadotropin-releasing_hormone -LRB- gnRH -RRB- promoter activity in transfected CHO-K1 cells .
9027565	0	gonadotropin-releasing_hormone	169,199	gonadotropin-releasing_hormone_receptor	17,56	gonadotropin-releasing hormone	gonadotropin-releasing hormone receptor	443529(Tax:9940)	443413(Tax:9940)	Gene	Gene	immunization|nmod|START_ENTITY effect|nmod|immunization Concentration|dep|effect Concentration|nmod|acid acid|amod|END_ENTITY	Concentration of gonadotropin-releasing_hormone_receptor messenger ribonucleic acid in pituitary tissue of orchidectomized sheep : effect of passive immunization against gonadotropin-releasing_hormone .
9873026	0	gonadotropin-releasing_hormone	43,73	gonadotropin-releasing_hormone_receptor	105,144	gonadotropin-releasing hormone	gonadotropin-releasing hormone receptor	14714(Tax:10090)	14715(Tax:10090)	Gene	Gene	elements|amod|START_ENTITY Identification|nmod|elements Identification|nmod|gene gene|compound|END_ENTITY	Identification and characterization of the gonadotropin-releasing_hormone response elements in the mouse gonadotropin-releasing_hormone_receptor gene .
22343304	0	gonadotropin-releasing_hormone	26,56	kisspeptin	69,79	gonadotropin-releasing hormone	kisspeptin	443529(Tax:9940)	101107719	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Seasonal variation in the gonadotropin-releasing_hormone response to kisspeptin in sheep : possible kisspeptin regulation of the kisspeptin receptor .
10318795	0	gonadotropin-releasing_hormone	47,77	luteinizing_hormone_beta	14,38	gonadotropin-releasing hormone	luteinizing hormone beta	14714(Tax:10090)	16866(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Activation of luteinizing_hormone_beta gene by gonadotropin-releasing_hormone requires the synergy of early_growth_response-1_and_steroidogenic_factor-1 .
11165042	0	gonadotropin-releasing_hormone	64,94	mitogen-activated_protein_kinase_phosphatase_2	14,60	gonadotropin-releasing hormone	mitogen-activated protein kinase phosphatase 2	2796	1846	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mitogen-activated_protein_kinase_phosphatase_2 by gonadotropin-releasing_hormone .
10067858	0	gonadotropin-releasing_hormone	66,96	p38_mitogen-activated_protein_kinase	18,54	gonadotropin-releasing hormone	p38 mitogen-activated protein kinase	2796	1432	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|pathway pathway|amod|END_ENTITY	Activation of the p38_mitogen-activated_protein_kinase pathway by gonadotropin-releasing_hormone .
16444392	0	gonadotropin-releasing_hormone	55,85	prolactin	11,20	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	agonist|amod|START_ENTITY administration|nmod|agonist secretion|nmod|administration secretion|nsubj|Pattern Pattern|nmod|END_ENTITY	Pattern of prolactin secretion after administration of gonadotropin-releasing_hormone agonist at the preovulatory phase of intrauterine insemination cycles .
1901042	0	gonadotropin-releasing_hormone	50,80	prolactin	6,15	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	analogue|amod|START_ENTITY treated|nmod|analogue treated|nsubj|levels levels|compound|END_ENTITY	Serum prolactin levels in patients treated with a gonadotropin-releasing_hormone analogue for adenocarcinoma_of_the_prostate .
2114008	0	gonadotropin-releasing_hormone	43,73	prolactin	21,30	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Periovulatory plasma prolactin response to gonadotropin-releasing_hormone : role of endogenous opiates .
3087788	0	gonadotropin-releasing_hormone	43,73	prolactin	20,29	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of human prolactin secretion by gonadotropin-releasing_hormone in vitro .
3114203	0	gonadotropin-releasing_hormone	10,40	prolactin	44,53	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of gonadotropin-releasing_hormone on prolactin levels in males unrelated to stress or behavioral changes .
3147927	0	gonadotropin-releasing_hormone	35,65	prolactin	69,78	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of exogenous and endogenous gonadotropin-releasing_hormone on prolactin secretion in perimenopausal women .
356613	0	gonadotropin-releasing_hormone	117,147	prolactin	22,31	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	hormone|nmod|START_ENTITY levels|nmod|hormone levels|compound|END_ENTITY	The effect of varying prolactin levels on pituitary luteinizing hormone and follicle-stimulating hormone response to gonadotropin-releasing_hormone .
6813347	0	gonadotropin-releasing_hormone	48,78	prolactin	26,35	gonadotropin-releasing hormone	prolactin	2796	5617	Gene	Gene	response|dep|START_ENTITY response|compound|END_ENTITY	Estrogen-dependent plasma prolactin response to gonadotropin-releasing_hormone in intact and castrated men .
9153199	0	gonadotropin-releasing_hormone	81,111	protein_kinase_C_delta	27,49	gonadotropin-releasing hormone	protein kinase C delta	2796	5580	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Differential activation of protein_kinase_C_delta and epsilon gene expression by gonadotropin-releasing_hormone in alphaT3-1 cells .
19172544	0	gonadotropin-releasing_hormone	66,96	vascular_endothelial_growth_factor	25,59	gonadotropin-releasing hormone	vascular endothelial growth factor	2796	7422	Gene	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Elevated level of plasma vascular_endothelial_growth_factor after gonadotropin-releasing_hormone agonist treatment for leiomyomata .
11889221	0	gonadotropin-releasing_hormone_II	14,47	GnRH-II	49,56	gonadotropin-releasing hormone II	GnRH-II	2797	2797	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Expression of gonadotropin-releasing_hormone_II -LRB- GnRH-II -RRB- receptor in human endometrial_and_ovarian_cancer cells and effects of GnRH-II on tumor cell proliferation .
7557974	0	gonadotropin-releasing_hormone_receptor	33,72	GnRH-R	74,80	gonadotropin-releasing hormone receptor	GnRH-R	2798	2798	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Subregional mapping of the human gonadotropin-releasing_hormone_receptor -LRB- GnRH-R -RRB- gene to 4q between the markers D4S392 and D4S409 .
24472523	0	gonadotropin-releasing_hormone_receptor	9,48	GnRHR	50,55	gonadotropin-releasing hormone receptor	GnRHR	2798	2798	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Aberrant gonadotropin-releasing_hormone_receptor -LRB- GnRHR -RRB- expression and its regulation of CYP11B2 expression and aldosterone production in adrenal aldosterone-producing adenoma -LRB- APA -RRB- .
22024993	0	gonadotropin-releasing_hormone_receptor	31,70	Gonadotropin-releasing_hormone	0,30	gonadotropin-releasing hormone receptor	Gonadotropin-releasing hormone	2798	2796	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Gonadotropin-releasing_hormone / gonadotropin-releasing_hormone_receptor signaling in the placenta .
12062898	0	gonadotropin-releasing_hormone_receptor	18,57	RGS	69,72	gonadotropin-releasing hormone receptor	RGS	2798	5308	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Regulation of the gonadotropin-releasing_hormone_receptor -LRB- GnRHR -RRB- by RGS proteins : role of the GnRHR carboxyl-terminus .
19274343	0	gonadotropin-releasing_hormone_receptor	84,123	endoplasmic_reticulum_protein_chaperone_thio-oxidoreductase	21,80	gonadotropin-releasing hormone receptor	endoplasmic reticulum protein chaperone thio-oxidoreductase	2798	51060	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Participation of the endoplasmic_reticulum_protein_chaperone_thio-oxidoreductase in gonadotropin-releasing_hormone_receptor expression at the plasma membrane .
9027565	0	gonadotropin-releasing_hormone_receptor	17,56	gonadotropin-releasing_hormone	169,199	gonadotropin-releasing hormone receptor	gonadotropin-releasing hormone	443413(Tax:9940)	443529(Tax:9940)	Gene	Gene	acid|amod|START_ENTITY Concentration|nmod|acid Concentration|dep|effect effect|nmod|immunization immunization|nmod|END_ENTITY	Concentration of gonadotropin-releasing_hormone_receptor messenger ribonucleic acid in pituitary tissue of orchidectomized sheep : effect of passive immunization against gonadotropin-releasing_hormone .
9873026	0	gonadotropin-releasing_hormone_receptor	105,144	gonadotropin-releasing_hormone	43,73	gonadotropin-releasing hormone receptor	gonadotropin-releasing hormone	14715(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Identification|nmod|gene Identification|nmod|elements elements|amod|END_ENTITY	Identification and characterization of the gonadotropin-releasing_hormone response elements in the mouse gonadotropin-releasing_hormone_receptor gene .
6427062	0	gonadotropin-releasing_hormones	33,64	GnRH	66,70	gonadotropin-releasing hormones	GnRH	2796	2796	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of chicken and mammalian gonadotropin-releasing_hormones -LRB- GnRH -RRB- on in vivo pituitary gonadotropin release in amphibians and reptiles .
7985517	0	gonadotropin-releasing_peptide	11,41	GRP	43,46	gonadotropin-releasing peptide	GRP	225642(Tax:10090)	225642(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of gonadotropin-releasing_peptide -LRB- GRP -RRB- on LH secretion of mouse pituitary in vitro -RSB- .
8108395	0	gonadotropin_hormone-releasing_hormone	14,52	prolactin	111,120	gonadotropin hormone-releasing hormone	prolactin	25194(Tax:10116)	5617	Gene	Gene	release|amod|START_ENTITY Inhibition|nmod|release neuronal|nsubj|Inhibition neuronal|nmod|receptors receptors|compound|END_ENTITY	Inhibition of gonadotropin_hormone-releasing_hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors .
8108395	0	gonadotropin_hormone-releasing_hormone	14,52	prolactin	64,73	gonadotropin hormone-releasing hormone	prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Inhibition of gonadotropin_hormone-releasing_hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors .
9283045	0	gonadotropin_releasing_hormone	53,83	GNRH	85,89	gonadotropin releasing hormone	GNRH	2796	2796	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	The interactive language of the hypothalamus for the gonadotropin_releasing_hormone -LRB- GNRH -RRB- system .
2699145	0	gonadotropin_releasing_hormone	12,42	Gn-RH	44,49	gonadotropin releasing hormone	Gn-RH	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of gonadotropin_releasing_hormone -LRB- Gn-RH -RRB- in the regulation of gonadal functions of birds .
10937733	0	gonadotropin_releasing_hormone	14,44	GnRH	46,50	gonadotropin releasing hormone	GnRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Quinolones as gonadotropin_releasing_hormone -LRB- GnRH -RRB- antagonists : simultaneous optimization of the C -LRB- 3 -RRB- - aryl and C -LRB- 6 -RRB- - substituents .
3030856	0	gonadotropin_releasing_hormone	27,57	GnRH	59,63	gonadotropin releasing hormone	GnRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Blockade of rat testicular gonadotropin_releasing_hormone -LRB- GnRH -RRB- receptors by infusion of a GnRH antagonist has no major effects of Leydig cell function in vivo .
23785158	0	gonadotropin_releasing_hormone	18,48	NSCL-2	8,14	gonadotropin releasing hormone	NSCL-2	14714(Tax:10090)	18072(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Loss of NSCL-2 in gonadotropin_releasing_hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral_obesity .
12943720	0	gonadotropin_releasing_hormone	69,99	PKCdelta	40,48	gonadotropin releasing hormone	PKCdelta	2796	5580	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Activation and nuclear translocation of PKCdelta , Pyk2 and ERK1/2 by gonadotropin_releasing_hormone in HEK293 cells .
18504344	0	gonadotropin_releasing_hormone	40,70	annexin_A5	15,25	gonadotropin releasing hormone	annexin A5	25194(Tax:10116)	25673(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of annexin_A5 expression by gonadotropin_releasing_hormone -LRB- GnRH -RRB- in the Leydig cells of rats .
19912764	0	gonadotropin_releasing_hormone	11,41	c-fos	59,64	gonadotropin releasing hormone	c-fos	25194(Tax:10116)	314322(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of gonadotropin_releasing_hormone and estradiol on c-fos expression in the rat hippocampus .
25475593	0	gonadotropin_releasing_hormone	31,61	gnrh2	63,68	gonadotropin releasing hormone	gnrh2	2796	2797	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Brain aromatase -LRB- cyp19a1b -RRB- and gonadotropin_releasing_hormone -LRB- gnrh2 and gnrh3 -RRB- expression during reproductive development and sex change in black sea bass -LRB- Centropristis striata -RRB- .
2858814	0	gonadotropin_releasing_hormone	17,47	guanylate	62,71	gonadotropin releasing hormone	C.4.6.1.2	2796	1040044(Tax:199310)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Cation-dependent gonadotropin_releasing_hormone activation of guanylate cyclase .
21872303	0	gonadotropin_releasing_hormone-I	30,62	GnRH-I	64,70	gonadotropin releasing hormone-I	GnRH-I	770134(Tax:9031)	770134(Tax:9031)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and variation in gonadotropin_releasing_hormone-I -LRB- GnRH-I -RRB- immunoreactive neurons in the brain of the native Thai chicken during the reproductive cycle .
21104139	0	gonadotropin_releasing_hormone_receptor	48,87	GnRHR	89,94	gonadotropin releasing hormone receptor	GnRHR	281798(Tax:9913)	281798(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effects of MboII and BspMI polymorphisms in the gonadotropin_releasing_hormone_receptor -LRB- GnRHR -RRB- gene on sperm quality in Holstein bulls .
23378141	0	goosecoid	35,44	GSC	46,49	goosecoid	GSC	145258	145258	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Chronic ethanol exposure increases goosecoid -LRB- GSC -RRB- expression in human embryonic_carcinoma cell differentiation .
9428427	0	goosecoid	57,66	Xenopus_homeobox_gene_twin	4,30	goosecoid	Xenopus homeobox gene twin	397752(Tax:8355)	373692(Tax:8355)	Gene	Gene	induction|nmod|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	The Xenopus_homeobox_gene_twin mediates Wnt induction of goosecoid in establishment of Spemann 's organizer .
20638388	0	gp120	44,49	BEC1	91,95	gp120	BEC1	3700	23416	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human immunodeficiency virus gp120 with the voltage-gated potassium channel BEC1 .
10200301	0	gp120	46,51	CCR5	64,68	gp120	CCR5	3700	1234	Gene	Gene	START_ENTITY|acl|involved involved|nmod|utilization utilization|compound|END_ENTITY	Hypervariable region 3 residues of HIV_type_1 gp120 involved in CCR5 coreceptor utilization : therapeutic and prophylactic implications .
10333239	0	gp120	149,154	CCR5	177,181	gp120	CCR5	3700	1234	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Enhanced_human_immunodeficiency_virus_infection in macrophages by high-molecular-weight dextran sulfate is associated with conformational changes of gp120 and expression of the CCR5 receptor .
10413516	0	gp120	26,31	CCR5	53,57	gp120	CCR5	3700	1234	Gene	Gene	START_ENTITY|nmod|epitopes epitopes|nmod|site site|compound|END_ENTITY	Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic .
10438703	0	gp120	69,74	CCR5	140,144	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	derived|nmod|START_ENTITY peptide|acl|derived downregulates|nsubj|peptide downregulates|dobj|expression expression|nmod|END_ENTITY	A synthetic peptide derived from human_immunodeficiency_virus_type_1 gp120 downregulates the expression and function of chemokine receptors CCR5 and CXCR4 in monocytes by activating the 7-transmembrane G-protein-coupled receptor FPRL1/LXA4R .
10482572	0	gp120	86,91	CCR5	104,108	gp120	CCR5	3700	1234	Gene	Gene	loop|nmod|START_ENTITY domain|nmod|loop Analysis|nmod|domain involved|nsubj|Analysis involved|nmod|utilization utilization|compound|END_ENTITY	Analysis of the critical domain in the V3 loop of human_immunodeficiency_virus_type_1 gp120 involved in CCR5 utilization .
10758170	0	gp120	6,11	CCR5	80,84	gp120	CCR5	3700	1234	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|compound|END_ENTITY	HIV-1 gp120 and chemokines_activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation .
10823934	0	gp120	119,124	CCR5	24,28	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	containing|nmod|START_ENTITY peptides|xcomp|containing peptides|nsubj|interaction interaction|nmod|domain domain|compound|END_ENTITY	Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120 .
10938094	0	gp120	111,116	CCR5	55,59	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	glycoprotein|amod|START_ENTITY epitope|nmod|glycoprotein interacts|nmod|epitope interacts|nsubj|peptide peptide|nmod|terminus terminus|nmod|END_ENTITY	A tyrosine-sulfated peptide based on the N terminus of CCR5 interacts with a CD4-enhanced epitope of the HIV-1 gp120 envelope glycoprotein and inhibits HIV-1 entry .
12477875	0	gp120	65,70	CCR5	110,114	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	interaction|nummod|START_ENTITY interaction|nmod|END_ENTITY	CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5 .
12610158	0	gp120	121,126	CCR5	130,134	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|utilization utilization|compound|END_ENTITY	Effect of amino_acid substitution of the V3 and bridging sheet residues in human_immunodeficiency_virus_type_1 subtype C gp120 on CCR5 utilization .
12887918	0	gp120	102,107	CCR5	73,77	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	HIV-1|nummod|START_ENTITY region|nmod|HIV-1 region|compound|END_ENTITY	Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120 .
14517611	0	gp120	90,95	CCR5	56,60	gp120	CCR5	3700	1234	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies .
15321703	0	gp120	71,76	CCR5	80,84	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	HIV-1|nummod|START_ENTITY binding|nmod|HIV-1 binding|nmod|END_ENTITY	A novel assay to identify entry inhibitors that block binding of HIV-1 gp120 to CCR5 .
15767436	0	gp120	146,151	CCR5	69,73	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	mutations|nmod|START_ENTITY have|dobj|mutations lacking|ccomp|have lacking|nsubj|END_ENTITY	Variants of human_immunodeficiency_virus_type_1 that efficiently use CCR5 lacking the tyrosine-sulfated amino terminus have adaptive mutations in gp120 , including loss of a functional N-glycan .
15905975	0	gp120	97,102	CCR5	119,123	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	structure|nmod|START_ENTITY critical|nsubj|structure critical|nmod|binding binding|compound|END_ENTITY	Highly conserved beta16/beta17 beta-hairpin structure in human_immunodeficiency_virus_type_1 YU2 gp120 is critical for CCR5 binding .
16721558	0	gp120	46,51	CCR5	0,4	gp120	CCR5	3700	1234	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	CCR5 interactions with the variable 3 loop of gp120 .
17101166	0	gp120	153,158	CCR5	180,184	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|coreceptor coreceptor|compound|END_ENTITY	Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human_immunodeficiency_virus_type_1 gp120 interaction with the CCR5 coreceptor .
17239419	0	gp120	28,33	CCR5	108,112	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	region|nmod|START_ENTITY Changes|nmod|region contribute|nsubj|Changes contribute|nmod|heterozygote heterozygote|compound|END_ENTITY	Changes in the V3 region of gp120 contribute to unusually broad coreceptor usage of an HIV-1 isolate from a CCR5 Delta32 heterozygote .
17273779	0	gp120	69,74	CCR5	132,136	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	HIV-1|nummod|START_ENTITY V3-loop|nmod|HIV-1 derived|nmod|V3-loop peptides|acl|derived modeling|nmod|peptides modeling|dep|implications implications|nmod|interaction interaction|nmod|END_ENTITY	Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120 : implications of the interaction with chemokine receptor CCR5 .
17920626	0	gp120	32,37	CCR5	46,50	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	HIV-1|nummod|START_ENTITY rheostat|nmod|HIV-1 reduces|nsubj|rheostat reduces|dobj|END_ENTITY	An allosteric rheostat in HIV-1 gp120 reduces CCR5 stoichiometry required for membrane fusion and overcomes diverse entry limitations .
18190945	0	gp120	162,167	CCR5	26,30	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	domain|nmod|START_ENTITY reveals|nmod|domain reveals|dep|Mapping Mapping|nmod|vicriviroc vicriviroc|compound|END_ENTITY	Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120 .
19018669	0	gp120	81,86	CCR5	95,99	gp120	CCR5	3700	1234	Gene	Gene	protein|appos|START_ENTITY protein|nmod|coreceptor coreceptor|compound|END_ENTITY	High-affinity binding of southern African HIV_type_1 subtype C envelope protein , gp120 , to the CCR5 coreceptor .
19170639	0	gp120	103,108	CCR5	56,60	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	coreceptor|nmod|START_ENTITY coreceptor|nsubj|thermodynamics thermodynamics|nmod|peptide peptide|nmod|END_ENTITY	Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120 .
19776131	0	gp120	67,72	CCR5	128,132	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	analysis|nmod|START_ENTITY amino_acid|nsubj|analysis amino_acid|dobj|mutations mutations|acl|associated associated|nmod|vicriviroc vicriviroc|compound|END_ENTITY	Structure-function analysis of human_immunodeficiency_virus_type_1 gp120 amino_acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc .
20172579	0	gp120	88,93	CCR5	150,154	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	START_ENTITY|acl:relcl|alter alter|dobj|interactions interactions|nmod|END_ENTITY	Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5 .
21356539	0	gp120	132,137	CCR5	80,84	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	involve|nmod|START_ENTITY involve|nsubj|Resistance Resistance|nmod|isolate isolate|nmod|inhibitor inhibitor|compound|END_ENTITY	Resistance of a human_immunodeficiency_virus_type_1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41 .
21763489	0	gp120	94,99	CCR5	49,53	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	complex|nmod|START_ENTITY peptide|amod|complex peptide|nmod|peptide peptide|nsubj|conformation conformation|nmod|END_ENTITY	The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide .
22017448	0	gp120	106,111	CCR5	26,30	gp120	CCR5	3700	1234	Gene	Gene	elicited|nmod|START_ENTITY elicited|nsubj|effects effects|nmod|maraviroc maraviroc|compound|END_ENTITY	Modulatory effects of the CCR5 antagonist maraviroc on microglial pro-inflammatory activation elicited by gp120 .
24606688	0	gp120	106,111	CCR5	38,42	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubj|recognition recognition|nmod|END_ENTITY	Preferential recognition of monomeric CCR5 expressed in cultured cells by the HIV-1 envelope glycoprotein gp120 for the entry of R5 HIV-1 .
24763408	0	gp120	42,47	CCR5	25,29	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	loop|amod|START_ENTITY recognition|nmod|loop recognition|nmod|END_ENTITY	Molecular recognition of CCR5 by an HIV-1 gp120 V3 loop .
25703038	0	gp120	61,66	CCR5	12,16	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	binds|dobj|START_ENTITY helix|acl:relcl|binds forms|dobj|helix forms|nsubj|peptide peptide|compound|END_ENTITY	An extended CCR5 ECL2 peptide forms a helix that binds HIV-1 gp120 through non-specific hydrophobic interactions .
25797607	0	gp120	93,98	CCR5	182,186	gp120	CCR5	3700	1234	Gene	Gene	sheet|amod|START_ENTITY sheet|acl:relcl|increase increase|nmod|interactions interactions|nmod|END_ENTITY	Bioinformatic analysis of neurotropic HIV envelope sequences identifies polymorphisms in the gp120 bridging sheet that increase macrophage-tropism through enhanced interactions with CCR5 .
26114311	0	gp120	88,93	CCR5	110,114	gp120	CCR5	3700	12774(Tax:10090)	Gene	Gene	Crown|nmod:poss|START_ENTITY Interactions|nmod|Crown Reveal|dobj|Interactions Reveal|nmod|Loop Loop|compound|END_ENTITY	Short Communication : HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120 's V3 Crown with CCR5 Extracellular Loop 1 .
26114311	0	gp120	88,93	CCR5	51,55	gp120	CCR5	3700	12774(Tax:10090)	Gene	Gene	Crown|nmod:poss|START_ENTITY Interactions|nmod|Crown Reveal|dobj|Interactions Reveal|compound|END_ENTITY	Short Communication : HIV-1 Variants That Use Mouse CCR5 Reveal Critical Interactions of gp120 's V3 Crown with CCR5 Extracellular Loop 1 .
9334377	0	gp120	84,89	CCR5	34,38	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	binding|compound|START_ENTITY domains|nmod|binding Interaction|dep|domains Interaction|nmod|END_ENTITY	Interaction of chemokine receptor CCR5 with its ligands : multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding .
9420225	0	gp120	59,64	CCR5	36,40	gp120	CCR5	155971(Tax:11676)	1234	Gene	Gene	entry|amod|START_ENTITY impair|dobj|entry impair|nsubj|substitutions substitutions|nmod|coreceptor coreceptor|compound|END_ENTITY	Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human_immunodeficiency_virus_type_1 entry .
9576954	0	gp120	87,92	CCR5	0,4	gp120	CCR5	3700	1234	Gene	Gene	residue|nmod|START_ENTITY involves|dobj|residue involves|nsubj|utilization utilization|nummod|END_ENTITY	CCR5 coreceptor utilization involves a highly conserved arginine residue of HIV_type_1 gp120 .
15790518	0	gp120	29,34	CD1d	49,53	gp120	CD1d	3700	912	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Human immunodeficiency virus gp120 downregulates CD1d cell surface expression .
10064617	0	gp120	34,39	CD4	104,107	gp120	CD4	3700	920	Gene	Gene	domain-derived|compound|START_ENTITY chemokine|nsubj|domain-derived chemokine|nsubj|peptide peptide|acl:relcl|binds binds|nmod|END_ENTITY	A functional , discontinuous HIV-1 gp120 C3/C4 domain-derived , branched , synthetic peptide that binds to CD4 and inhibits MIP-1alpha chemokine binding .
10229873	0	gp120	18,23	CD4	33,36	gp120	CD4	3700	920	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|chemotaxis chemotaxis|compound|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10229873	0	gp120	18,23	CD4	90,93	gp120	CD4	3700	920	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|CXCR4 CXCR4|nmod|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10356363	0	gp120	66,71	CD4	41,44	gp120	CD4	3700	920	Gene	Gene	protein|amod|START_ENTITY express|nmod|protein express|dobj|END_ENTITY	Human glomerular epithelial cell express CD4 and interaction with gp120 protein promotes PYK2 tyrosine phosphorylation .
10358157	0	gp120	105,110	CD4	114,117	gp120	CD4	155971(Tax:11676)	12504(Tax:10090)	Gene	Gene	HIV-1|nummod|START_ENTITY chemokine|nmod|HIV-1 chemokine|nmod|cells cells|compound|END_ENTITY	Inhibition of tyrosine kinase activation blocks the down-regulation of CXC chemokine receptor 4 by HIV-1 gp120 in CD4 + T cells .
10413516	0	gp120	26,31	CD4	86,89	gp120	CD4	3700	920	Gene	Gene	changes|nmod|START_ENTITY induced|nsubjpass|changes induced|nmod|END_ENTITY	Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic .
10438529	0	gp120	73,78	CD4	9,12	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	glycoproteins|amod|START_ENTITY Roles|nmod|glycoproteins Roles|nmod|END_ENTITY	Roles of CD4 and coreceptors in binding , endocytosis , and proteolysis of gp120 envelope glycoproteins derived from human_immunodeficiency_virus_type_1 .
10555208	0	gp120	59,64	CD4	135,138	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	binds|nsubj|START_ENTITY binds|advcl|CXC-R4 CXC-R4|nmod|presence presence|nmod|END_ENTITY	In a human lymphomyeloid progenitor cell line -LRB- KG-1 -RRB- HIV-1 gp120 binds to chemokine-receptors CXC-R4 and CCR5 , only in the presence of CD4 .
10775592	0	gp120	95,100	CD4	118,121	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	interaction|amod|START_ENTITY blocking|nmod|interaction blocking|nmod|END_ENTITY	Multiple antiviral activities of cyanovirin-N : blocking of human_immunodeficiency_virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses .
10779509	0	gp120	70,75	CD4	36,39	gp120	CD4	3700	920	Gene	Gene	function|nmod|START_ENTITY function|nmod|molecules molecules|compound|END_ENTITY	Coreceptor function of mutant human CD4 molecules without affinity to gp120 of human_immunodeficiency_virus .
10899322	0	gp120	10,15	CD4	96,99	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|the the|nmod|expression expression|amod|adenosine_deaminase adenosine_deaminase|nmod|CD26 CD26|nmod|mechanism mechanism|acl|modulated modulated|nmod|END_ENTITY	The HIV-1 gp120 inhibits the binding of adenosine_deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression .
10941932	0	gp120	74,79	CD4	44,47	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	primed|nmod|START_ENTITY primed|nsubj|level level|nmod|co-down-modulation co-down-modulation|nmod|END_ENTITY	Differential level in co-down-modulation of CD4 and CXCR4 primed by HIV-1 gp120 in response to phorbol_ester , PMA , among HIV-1 isolates .
11192301	0	gp120	70,75	CD4	95,98	gp120	CD4	3700	920	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|binding binding|nmod|END_ENTITY	Short synthetic peptides derived from viral proteins compete with HIV gp120 for the binding to CD4 receptors .
11290759	0	gp120	48,53	CD4	94,97	gp120	CD4	3700	920	Gene	Gene	mechanism|nmod|START_ENTITY induced|nsubj|mechanism induced|dobj|loss loss|nmod|END_ENTITY	A CCR5-dependent novel mechanism for type 1 HIV gp120 induced loss of macrophage cell surface CD4 .
11305358	0	gp120	87,92	CD4	13,16	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	immunogenicity|nmod|START_ENTITY studying|dobj|immunogenicity transgenic_mice|advcl|studying transgenic_mice|nsubj|Use Use|nmod|END_ENTITY	Use of human CD4 transgenic_mice for studying immunogenicity of HIV-1 envelope protein gp120 .
11327825	0	gp120	109,114	CD4	120,123	gp120	CD4	3700	920	Gene	Gene	interaction|nmod|START_ENTITY kinetics|nmod|interaction weakens|dobj|kinetics weakens|nmod|END_ENTITY	Antibody 17b binding at the coreceptor site weakens the kinetics of the interaction of envelope glycoprotein gp120 with CD4 .
11356967	0	gp120	87,92	CD4	31,34	gp120	CD4	3700	920	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Antigenic variation within the CD4 binding site of human_immunodeficiency_virus_type_1 gp120 : effects on chemokine receptor utilization .
11409875	0	gp120	78,83	CD4	27,30	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	domain|nmod|START_ENTITY function|nmod|domain function|nsubj|Dys-regulation Dys-regulation|nmod|cell cell|compound|END_ENTITY	Dys-regulation of effector CD4 + T cell function by the V3 domain of the HIV-1 gp120 during antigen presentation .
11602735	0	gp120	137,142	CD4	115,118	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11602735	0	gp120	137,142	CD4	72,75	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	domain|nmod|START_ENTITY specific|nmod|domain antibodies|amod|specific T|nmod|antibodies T|nsubj|Inhibition Inhibition|nmod|presentation presentation|nmod|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11602735	0	gp120	50,55	CD4	115,118	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	presentation|amod|START_ENTITY Inhibition|nmod|presentation T|nsubj|Inhibition T|nmod|antibodies antibodies|amod|specific specific|nmod|domain domain|compound|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11602735	0	gp120	50,55	CD4	72,75	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	presentation|amod|START_ENTITY presentation|nmod|END_ENTITY	Inhibition of human_immunodeficiency_virus_type_1 gp120 presentation to CD4 T cells by antibodies specific for the CD4 binding domain of gp120 .
11777947	0	gp120	84,89	CD4	7,10	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	expressing|dobj|START_ENTITY elicited|xcomp|expressing elicited|nsubj|responses responses|compound|END_ENTITY	Potent CD4 + T cell responses elicited by a bicistronic HIV-1 DNA vaccine expressing gp120 and GM-CSF .
12097605	0	gp120	84,89	CD4	129,132	gp120	CD4	3700	920	Gene	Gene	variants|amod|START_ENTITY selection|nmod|variants accompanied|nmod|selection accompanied|nmod|ability ability|nmod|END_ENTITY	Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4 .
12477867	0	gp120	155,160	CD4	99,102	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human_immunodeficiency_virus_type_1 gp120 .
12477875	0	gp120	65,70	CD4	0,3	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	interaction|nummod|START_ENTITY inhibit|dobj|interaction inhibit|nsubj|antibodies antibodies|nummod|END_ENTITY	CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5 .
12584309	0	gp120	135,140	CD4	146,149	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	interaction|nmod|START_ENTITY based|nmod|interaction based|nmod|END_ENTITY	Neutralization of human_immunodeficiency_virus_type_1 by sCD4-17b , a single-chain chimeric protein , based on sequential interaction of gp120 with CD4 and coreceptor .
1279195	0	gp120	56,61	CD4	104,107	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	loop|amod|START_ENTITY loop|nmod|component component|nmod|site site|compound|END_ENTITY	Relationship of the human_immunodeficiency_virus_type_1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region .
1352879	0	gp120	113,118	CD4	26,29	gp120	CD4	3700	920	Gene	Gene	inhibits|dobj|START_ENTITY Design|acl:relcl|inhibits Design|nmod|mimetic mimetic|compound|END_ENTITY	Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes .
1353060	0	gp120	109,114	CD4	58,61	gp120	CD4	3700	920	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|cells cells|nummod|END_ENTITY	Analysis of the basis of resistance and susceptibility of CD4 + T cells to human immunodeficiency virus -LRB- HIV -RRB- - gp120 induced anergy .
1356673	0	gp120	83,88	CD4	103,106	gp120	CD4	3700	920	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Human_immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro : a possible mechanism of T lymphocyte depletion in vivo .
14498981	0	gp120	89,94	CD4	28,31	gp120	CD4	3700	920	Gene	Gene	variants|amod|START_ENTITY CCR5-tropic|appos|variants sites|nmod|CCR5-tropic induced|dobj|sites induced|nsubj|variations variations|nmod|END_ENTITY	Antigenic variations in the CD4 induced sites of the CCR5-tropic , pathogenic SHIVsf162p3 gp120 variants .
14585210	0	gp120	61,66	CD4	15,18	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Propagation of CD4 + T cells specific for HIV_type_1 envelope gp120 from chronically HIV_type_1-infected subjects .
1465431	0	gp120	29,34	CD4	57,60	gp120	CD4	3700	920	Gene	Gene	ridge|compound|START_ENTITY ridge|nmod|domain domain|compound|END_ENTITY	Human_immunodeficiency virus gp120 binding C ` C '' ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules .
14691297	0	gp120	89,94	CD4	104,107	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY cells|nmod|HIV-1 Induction|nmod|cells Induction|dep|role role|nmod|coreceptors coreceptors|compound|END_ENTITY	Induction of intercellular_adhesion_molecule-1 on human brain endothelial cells by HIV-1 gp120 : role of CD4 and chemokine coreceptors .
1493053	0	gp120	147,152	CD4	138,141	gp120	CD4	3700	920	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|interaction interaction|nmod|END_ENTITY	Changes in the reactivity and neutralizing activity of a type-specific neutralizing monoclonal antibody induced by interaction of soluble CD4 with gp120 .
1500858	0	gp120	33,38	CD4	55,58	gp120	CD4	3700	920	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	The human immunodeficiency virus gp120 binding site on CD4 : delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure .
15103622	0	gp120	76,81	CD4	24,27	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY binding-induced|nmod|HIV-1 binding-induced|nsubj|insight insight|nmod|END_ENTITY	Atomic insight into the CD4 binding-induced conformational changes in HIV-1 gp120 .
15327894	0	gp120	20,25	CD4	49,52	gp120	CD4	3700	920	Gene	Gene	Determinants|nmod|START_ENTITY contribute|nsubj|Determinants contribute|nmod|independence independence|nummod|END_ENTITY	Determinants within gp120 and gp41 contribute to CD4 independence of SIV Envs .
1533631	0	gp120	96,101	CD4	113,116	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY interaction|nmod|HIV-1 analysis|nmod|interaction screen|nmod|analysis screen|nmod|END_ENTITY	An efficient phage plaque screen for the random mutational analysis of the interaction of HIV-1 gp120 with human CD4 .
1535086	0	gp120	36,41	CD4	89,92	gp120	CD4	3700	920	Gene	Gene	Internalization|nmod|START_ENTITY associated|nsubjpass|Internalization associated|nmod|down-modulation down-modulation|nmod|membrane membrane|nummod|END_ENTITY	Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment_of_T cell activation .
1537336	0	gp120	116,121	CD4	45,48	gp120	CD4	3700	920	Gene	Gene	express|dobj|START_ENTITY cells|acl:relcl|express kills|dobj|cells kills|nsubj|protein protein|compound|END_ENTITY	A recombinant diphtheria toxin related human CD4 fusion protein specifically kills HIV_infected cells which express gp120 but selects fusion toxin resistant cells which carry HIV .
15890908	0	gp120	76,81	CD4	17,20	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	START_ENTITY|amod|Interaction Interaction|nmod|END_ENTITY	Interaction with CD4 and antibodies to CD4-induced epitopes of the envelope gp120 from a microglial cell-adapted human_immunodeficiency_virus_type_1 isolate .
15893666	0	gp120	74,79	CD4	25,28	gp120	CD4	3700	920	Gene	Gene	structures|amod|START_ENTITY mimics|nmod|structures mimics|nmod|END_ENTITY	Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures , molecular mimicry , and neutralization breadth .
15946678	0	gp120	50,55	CD4	0,3	gp120	CD4	3700	920	Gene	Gene	locks|nmod|START_ENTITY locks|nsubj|binding binding|compound|END_ENTITY	CD4 binding partially locks the bridging sheet in gp120 but leaves the beta2/3 strands flexible .
1614536	0	gp120	19,24	CD4	40,43	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	recognition|compound|START_ENTITY recognition|nmod|END_ENTITY	Antibody and HIV-1 gp120 recognition of CD4 undermines the concept of mimicry between antibodies and receptors .
16189008	0	gp120	158,163	CD4	127,130	gp120	CD4	3700	920	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Structure of the Fab fragment of F105 , a broadly reactive anti-human immunodeficiency virus -LRB- HIV -RRB- antibody that recognizes the CD4 binding site of HIV_type_1 gp120 .
16260021	0	gp120	6,11	CD4	58,61	gp120	CD4	3700	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|translocation translocation|nmod|T-cells T-cells|compound|END_ENTITY	HIV-1 gp120 induces NFAT nuclear translocation in resting CD4 + T-cells .
16331979	0	gp120	28,33	CD4	58,61	gp120	CD4	3700	920	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Protein minimization of the gp120 binding region of human CD4 .
1656094	0	gp120	59,64	CD4	110,113	gp120	CD4	3700	920	Gene	Gene	induce|nsubj|START_ENTITY induce|nmod|clones clones|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4 + T-cell clones .
1696717	0	gp120	100,105	CD4	11,14	gp120	CD4	3700	920	Gene	Gene	regions|nmod|START_ENTITY cells|nmod|regions cells|compound|END_ENTITY	Priming of CD4 + T cells specific for conserved regions of human_immunodeficiency_virus glycoprotein gp120 in humans immunized with a recombinant envelope_protein .
1698804	0	gp120	23,28	CD4	79,82	gp120	CD4	3700	920	Gene	Gene	expression|amod|START_ENTITY protein|dobj|expression protein|parataxis|binding binding|nsubj|assessment assessment|nmod|END_ENTITY	HIV-1 envelope protein gp120 expression by secretion in E. _ coli : assessment of CD4 binding and use in epitope mapping .
1698964	0	gp120	36,41	CD4	24,27	gp120	CD4	3700	920	Gene	Gene	bearing|nmod|START_ENTITY bearing|dobj|bind bind|compound|END_ENTITY	Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120 .
1698964	0	gp120	93,98	CD4	24,27	gp120	CD4	3700	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing covered|nmod|cells covered|nsubj|cells cells|acl|bearing bearing|dobj|bind bind|compound|END_ENTITY	Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120 .
1706342	0	gp120	54,59	CD4	24,27	gp120	CD4	3700	920	Gene	Gene	site|amod|START_ENTITY site|compound|END_ENTITY	A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV_infection and virus-mediated fusion .
1711118	0	gp120	69,74	CD4	78,81	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY binding|nmod|HIV-1 binding|nmod|END_ENTITY	Phosphorothioate oligodeoxycytidine interferes with binding of HIV-1 gp120 to CD4 .
17131136	0	gp120	52,57	CD4	99,102	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY properties|nmod|HIV-1 geometrical|dobj|properties geometrical|nmod|changes changes|acl|induced induced|nmod|binding binding|compound|END_ENTITY	Dynamic domains and geometrical properties of HIV-1 gp120 during conformational changes induced by CD4 binding .
1713692	0	gp120	137,142	CD4	39,42	gp120	CD4	3700	920	Gene	Gene	interactions|nmod|START_ENTITY antigens|nsubj|interactions affect|ccomp|antigens affect|nsubj|Mutations Mutations|nmod|strand strand|nmod|domain domain|compound|END_ENTITY	Mutations in the D strand of the human CD4 V1 domain affect CD4 interactions with the human_immunodeficiency_virus envelope glycoprotein gp120 and HLA class II antigens similarly .
1713692	0	gp120	137,142	CD4	60,63	gp120	CD4	3700	920	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	Mutations in the D strand of the human CD4 V1 domain affect CD4 interactions with the human_immunodeficiency_virus envelope glycoprotein gp120 and HLA class II antigens similarly .
17180012	0	gp120	38,43	CD4	4,7	gp120	CD4	3700	920	Gene	Gene	identities|nmod|START_ENTITY identities|compound|END_ENTITY	Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis ?
1720631	0	gp120	37,42	CD4	63,66	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY 105-117|nmod|HIV-1 involved|nsubjpass|105-117 involved|nmod|binding binding|compound|END_ENTITY	N-terminal residues 105-117 of HIV-1 gp120 are not involved in CD4 binding .
1727487	0	gp120	151,156	CD4	85,88	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	retention|amod|START_ENTITY differ|nmod|retention differ|nsubj|neutralization neutralization|amod|resistant resistant|nmod|END_ENTITY	Virions of primary human_immunodeficiency_virus_type_1 isolates resistant to soluble CD4 -LRB- sCD4 -RRB- neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates .
1730924	0	gp120	71,76	CD4	84,87	gp120	CD4	155971(Tax:11676)	24932(Tax:10116)	Gene	Gene	site|nmod|START_ENTITY Construction|nmod|site Construction|nmod|END_ENTITY	Construction of a binding site for human_immunodeficiency_virus_type_1 gp120 in rat CD4 .
1732513	0	gp120	71,76	CD4	58,61	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	binding|compound|START_ENTITY charged|nmod|binding charged|nmod|region region|nmod|END_ENTITY	Contribution of charged amino_acids in the CDR2 region of CD4 to HIV-1 gp120 binding .
1736526	0	gp120	100,105	CD4	72,75	gp120	CD4	3700	920	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Human_immunodeficiency_virus_type_2 envelope glycoprotein : differential CD4 interactions of soluble gp120 versus the assembled envelope complex .
1738091	0	gp120	100,105	CD4	122,125	gp120	CD4	3700	920	Gene	Gene	glycoprotein|amod|START_ENTITY type|dobj|glycoprotein type|nmod|binding binding|compound|END_ENTITY	Contribution of disulfide bonds in the carboxyl terminus of the human immunodeficiency virus type I gp120 glycoprotein to CD4 binding .
1741386	0	gp120	169,174	CD4	99,102	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	lower|nmod|START_ENTITY due|xcomp|lower due|nsubj|Resistance Resistance|nmod|isolates isolates|nmod|human_immunodeficiency_virus_type_1 human_immunodeficiency_virus_type_1|nmod|neutralization neutralization|nmod|END_ENTITY	Resistance of primary isolates of human_immunodeficiency_virus_type_1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120 .
18322210	0	gp120	79,84	CD4	133,136	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	region|nmod|START_ENTITY glycosylation|nmod|region glycosylation|acl:relcl|critical critical|nmod|recognition recognition|nmod|cell cell|compound|END_ENTITY	Identification of an N-linked glycosylation in the C4 region of HIV-1 envelope gp120 that is critical for recognition of neighboring CD4 T cell epitopes .
18638381	0	gp120	44,49	CD4	74,77	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY site|nmod|HIV-1 Antibodies|nmod|site suppress|nsubj|Antibodies suppress|dobj|response response|compound|END_ENTITY	Antibodies to the CD4-binding site of HIV-1 gp120 suppress gp120-specific CD4 T cell response while enhancing antibody response .
1870202	0	gp120	83,88	CD4	102,105	gp120	CD4	155971(Tax:11676)	24932(Tax:10116)	Gene	Gene	affinity|amod|START_ENTITY affinity|nmod|END_ENTITY	Recombinant CD4-selected human_immunodeficiency_virus_type_1 variants with reduced gp120 affinity for CD4 and increased cell fusion capacity .
1888898	0	gp120	34,39	CD4	19,22	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY interaction|nmod|HIV-1 interaction|nmod|END_ENTITY	The interaction of CD4 with HIV-1 gp120 .
1896455	0	gp120	28,33	CD4	136,139	gp120	CD4	155971(Tax:11676)	450124(Tax:9598)	Gene	Gene	dissociation|amod|START_ENTITY dissociation|nmod|complex complex|nmod|human_immunodeficiency_virus_type_1 human_immunodeficiency_virus_type_1|nmod|END_ENTITY	Stimulation of glycoprotein gp120 dissociation from the envelope glycoprotein complex of human_immunodeficiency_virus_type_1 by soluble CD4 and CD4 peptide derivatives : implications for the role of the complementarity-determining region 3-like region in membrane fusion .
19000821	0	gp120	75,80	CD4	15,18	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY pocket|nmod|HIV-1 mimics|nmod|pocket mimics|nsubj|END_ENTITY	Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120 .
19297493	0	gp120	36,41	CD4	59,62	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	reprogramming|amod|START_ENTITY reprogramming|nmod|migration migration|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 gp120 reprogramming of CD4 + T-cell migration provides a mechanism for lymphadenopathy .
19572053	0	gp120	25,30	CD4	0,3	gp120	CD4	3700	920	Gene	Gene	Treated|nmod|START_ENTITY Treated|compound|END_ENTITY	CD4 T Cells Treated with gp120 Acquire a CD45R0 + / CD45RA + Phenotype .
1978941	0	gp120	155,160	CD4	71,74	gp120	CD4	3700	920	Gene	Gene	involved|nmod|START_ENTITY involved|nsubj|analysis analysis|nmod|residues residues|nmod|region region|nmod|END_ENTITY	Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules .
19965434	0	gp120	74,79	CD4	50,53	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY attachment|nmod|HIV-1 attachment|compound|END_ENTITY	Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120 .
2006155	0	gp120	131,136	CD4	19,22	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|Binding Binding|nmod|proteins proteins|compound|END_ENTITY	Binding of soluble CD4 proteins to human_immunodeficiency_virus_type_1 and infected cells induces release of envelope glycoprotein gp120 .
20089638	0	gp120	20,25	CD4	47,50	gp120	CD4	3700	920	Gene	Gene	element|amod|START_ENTITY element|acl|disrupted disrupted|nmod|binding binding|compound|END_ENTITY	A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer .
2018763	0	gp120	116,121	CD4	23,26	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	capacity|nmod|START_ENTITY Deamidation|nmod|capacity Deamidation|nmod|END_ENTITY	Deamidation of soluble CD4 at asparagine-52 results in reduced binding capacity for the HIV-1 envelope glycoprotein gp120 .
20357769	0	gp120	29,34	CD4	44,47	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	START_ENTITY|acl|bound bound|nmod|antibody antibody|compound|END_ENTITY	Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity .
2040625	0	gp120	39,44	CD4	120,123	gp120	CD4	3700	920	Gene	Gene	glycoprotein|amod|START_ENTITY Effect|nmod|glycoprotein tyrosine|nsubj|Effect tyrosine|nmod|END_ENTITY	Effect of human_immunodeficiency_virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes .
2040664	0	gp120	141,146	CD4	21,24	gp120	CD4	3700	920	Gene	Gene	glycoprotein|appos|START_ENTITY derivative|nmod|glycoprotein probed|nmod|derivative probed|nsubj|diffusion diffusion|nmod|END_ENTITY	Lateral diffusion of CD4 on the surface of a human neoplastic T-cell line probed with a fluorescent derivative of the envelope glycoprotein -LRB- gp120 -RRB- of human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- .
20558728	0	gp120	56,61	CD4	86,89	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	immunogen|amod|START_ENTITY immunogen|acl:relcl|binds binds|nmod|END_ENTITY	Design of a non-glycosylated outer_domain-derived HIV-1 gp120 immunogen that binds to CD4 and induces neutralizing antibodies .
20610714	0	gp120	6,11	CD4	41,44	gp120	CD4	3700	920	Gene	Gene	determinants|nsubj|START_ENTITY determinants|dobj|glycans glycans|amod|proximal proximal|nmod|shift shift|compound|END_ENTITY	HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12 .
20619663	0	gp120	142,147	CD4	138,141	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	paradigm|amod|START_ENTITY END_ENTITY|dep|paradigm	Rational conversion of noncontinuous active region in proteins into a small orally bioavailable macrocyclic drug-like molecule : the HIV-1 CD4 : gp120 paradigm .
2062847	0	gp120	83,88	CD4	0,3	gp120	CD4	3700	920	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|conjugates conjugates|nummod|END_ENTITY	CD4 peptide-protein conjugates , but not recombinant human CD4 , bind to recombinant gp120 from the human_immunodeficiency_virus in the presence of serum from AIDS patients .
2115689	0	gp120	89,94	CD4	50,53	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Prevention Prevention|nmod|HIV-1_infection HIV-1_infection|nmod|END_ENTITY	Prevention of HIV-1_infection and preservation of CD4 function by the binding of CPFs to gp120 .
21635737	0	gp120	62,67	CD4	34,37	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	cavity|nmod|START_ENTITY cavity|compound|END_ENTITY	Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissues .
21850260	0	gp120	13,18	CD4	38,41	gp120	CD4	3700	920	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|T-lymphocytes T-lymphocytes|compound|END_ENTITY	HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin -LRB- LtxA -RRB- .
22117536	0	gp120	17,22	CD4	74,77	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	glycoprotein|amod|START_ENTITY Binding|nmod|glycoprotein modified|csubj|Binding modified|nmod|glycoprotein glycoprotein|compound|END_ENTITY	Binding of HIV-1 gp120 glycoprotein to silica nanoparticles modified with CD4 glycoprotein and CD4 peptide fragments .
22312332	0	gp120	99,104	CD4	115,118	gp120	CD4	155971(Tax:11676)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Peptides Peptides|compound|END_ENTITY	Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction : Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides .
22345481	0	gp120	16,21	CD4	22,25	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	PGV04 , an HIV-1 gp120 CD4 binding site antibody , is broad and potent in neutralization but does not induce conformational changes characteristic of CD4 .
2251501	0	gp120	16,21	CD4	60,63	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Dissociation|nmod|START_ENTITY induced|nsubj|Dissociation induced|nmod|END_ENTITY	Dissociation of gp120 from HIV-1_virions induced by soluble CD4 .
22551420	0	gp120	65,70	CD4	71,74	gp120	CD4	3700	920	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency .
22906742	0	gp120	47,52	CD4	108,111	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	proteins|nmod|START_ENTITY showed|nsubj|proteins showed|dobj|enhanced enhanced|nmod|antibodies antibodies|compound|END_ENTITY	Fusion proteins of HIV-1 envelope glycoprotein gp120 with CD4-induced antibodies showed enhanced binding to CD4 and CD4 binding site antibodies .
22954308	0	gp120	4,9	CD4	59,62	gp120	CD4	3700	920	Gene	Gene	chemoattractant|nsubj|START_ENTITY chemoattractant|nmod|blood blood|acl|resting resting|dobj|cells cells|compound|END_ENTITY	HIV gp120 is an aberrant chemoattractant for blood resting CD4 T cells .
2304000	0	gp120	95,100	CD4	11,14	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY Effects|nmod|HIV-1 Effects|nmod|binding binding|compound|END_ENTITY	Effects on CD4 binding of anti-peptide sera to the fourth and fifth conserved domains of HIV-1 gp120 .
23077246	0	gp120	79,84	CD4	98,101	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	alterations|nmod|START_ENTITY engages|nsubj|alterations engages|dobj|END_ENTITY	Macrophage-tropic HIV-1 variants from brain demonstrate alterations in the way gp120 engages both CD4 and CCR5 .
23135713	0	gp120	100,105	CD4	45,48	gp120	CD4	3700	920	Gene	Gene	conferred|nmod|START_ENTITY conferred|nmod|mutation mutation|compound|END_ENTITY	HIV-1 resistance to maraviroc conferred by a CD4 binding site mutation in the envelope glycoprotein gp120 .
2315327	0	gp120	58,63	CD4	91,94	gp120	CD4	3700	920	Gene	Gene	produces|nsubj|START_ENTITY produces|dobj|defects defects|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 produces immune defects in CD4 + T lymphocytes by inhibiting interleukin_2 mRNA .
23297802	0	gp120	29,34	CD4	57,60	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	mutations|nummod|START_ENTITY that|nmod:npmod|mutations reduce|advmod|that reduce|xcomp|binding binding|nsubj|END_ENTITY	Molecular mechanism of HIV-1 gp120 mutations that reduce CD4 binding affinity .
2339113	0	gp120	80,85	CD4	123,126	gp120	CD4	3700	920	Gene	Gene	region|nmod|START_ENTITY contains|nsubj|region contains|dobj|sites sites|nmod|END_ENTITY	The N-terminal region of the human immunodeficiency virus envelope glycoprotein gp120 contains potential binding sites for CD4 .
23658524	0	gp120	103,108	CD4	62,65	gp120	CD4	3700	920	Gene	Gene	base|amod|START_ENTITY recognition|nmod|base binding|nmod|recognition binding|compound|END_ENTITY	Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans .
23991039	0	gp120	44,49	CD4	24,27	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	A human antibody to the CD4 binding site of gp120 capable of highly potent but sporadic cross clade neutralization of primary HIV-1 .
24516533	0	gp120	97,102	CD4	46,49	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	complexes|amod|START_ENTITY retention|nmod|complexes causes|dobj|retention causes|nsubj|turnover turnover|nmod|receptors receptors|nmod|cells cells|compound|END_ENTITY	Slow turnover of HIV-1 receptors on quiescent CD4 + T cells causes prolonged surface retention of gp120 immune complexes in vivo .
24550395	0	gp120	97,102	CD4	138,141	gp120	CD4	3700	920	Gene	Gene	glycoprotein|appos|START_ENTITY glycoprotein|acl:relcl|impairs impairs|dobj|dimerization dimerization|compound|END_ENTITY	Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 -LRB- gp120 -RRB- , which impairs thioredoxin-driven CD4 dimerization .
24550395	0	gp120	97,102	CD4	23,26	gp120	CD4	3700	920	Gene	Gene	glycoprotein|appos|START_ENTITY essential|nmod|glycoprotein essential|nsubj|reduction reduction|nmod|1 1|nummod|END_ENTITY	Disulfide reduction in CD4 domain 1 or 2 is essential for interaction with HIV glycoprotein 120 -LRB- gp120 -RRB- , which impairs thioredoxin-driven CD4 dimerization .
24758333	0	gp120	130,135	CD4	227,230	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Impact|nmod|START_ENTITY Impact|nmod|site site|compound|END_ENTITY	Impact of amino_acid substitutions in the V2 and C2 regions of human_immunodeficiency_virus_type_1 CRF01_AE envelope_glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site .
2537355	1	gp120	94,99	CD4	67,70	gp120	CD4	3700	920	Gene	Gene	presentation|nmod|START_ENTITY Role|nmod|presentation Role|nmod|END_ENTITY	Role of monocyte CD4 in the presentation of gp120 .
2543930	0	gp120	73,78	CD4	24,27	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY MHC|nmod|HIV-1 binding|nsubj|MHC affecting|xcomp|binding Identification|acl|affecting Identification|nmod|residues residues|compound|END_ENTITY	Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding .
2545782	0	gp120	96,101	CD4	42,45	gp120	CD4	3700	920	Gene	Gene	protein|appos|START_ENTITY inhibit|dobj|protein sulfate|advcl|inhibit sulfate|dobj|interact interact|nmod|molecules molecules|nummod|END_ENTITY	Dextran sulfate and heparin interact with CD4 molecules to inhibit the binding of coat protein -LRB- gp120 -RRB- of HIV .
25472996	0	gp120	25,30	CD4	46,49	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|CD4 CD4|compound|END_ENTITY	The Orientation of HIV-1 gp120 Binding to the CD4 Receptor Differentially Modulates CD4 + T Cell Activation .
25472996	0	gp120	25,30	CD4	84,87	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|END_ENTITY	The Orientation of HIV-1 gp120 Binding to the CD4 Receptor Differentially Modulates CD4 + T Cell Activation .
2561054	0	gp120	67,72	CD4	106,109	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|recognition recognition|compound|END_ENTITY	Oligosaccharide-mediated interactions of the envelope glycoprotein gp120 of HIV-1 that are independent of CD4 recognition .
25639621	0	gp120	111,116	CD4	91,94	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|Site Site|compound|END_ENTITY	Enhancement and Induction of HIV-1 Infection through an Assembled Peptide Derived from the CD4 Binding Site of gp120 .
25915507	0	gp120	74,79	CD4	91,94	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|Receptor Receptor|compound|END_ENTITY	HbAHP-25 , an In-Silico Designed Peptide , Inhibits HIV-1 Entry by Blocking gp120 Binding to CD4 Receptor .
25915507	0	gp120	74,79	CD4	91,94	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|Receptor Receptor|compound|END_ENTITY	HbAHP-25 , an In-Silico Designed Peptide , Inhibits HIV-1 Entry by Blocking gp120 Binding to CD4 Receptor .
26671829	0	gp120	57,62	CD4	37,40	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Study of antibody repertoires to the CD4 binding site of gp120 of a Chinese_HIV-1-infected_elite_neutralizer , using 454 sequencing and single-cell sorting .
2845130	0	gp120	78,83	CD4	95,98	gp120	CD4	3700	920	Gene	Gene	prevent|dobj|START_ENTITY prevent|nmod|END_ENTITY	Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4 .
3037522	0	gp120	51,56	CD4	67,70	gp120	CD4	3700	920	Gene	Gene	glycoprotein|appos|START_ENTITY glycoprotein|dep|bound bound|nmod|determinants determinants|nummod|END_ENTITY	Human T-cell lymphotropic virus IIIB glycoprotein -LRB- gp120 -RRB- bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack .
3261864	0	gp120	59,64	CD4	110,113	gp120	CD4	3700	920	Gene	Gene	site|nmod|START_ENTITY located|nsubjpass|site located|nmod|region region|nmod|T4 T4|appos|END_ENTITY	Binding site for human immunodeficiency virus coat protein gp120 is located in the NH2-terminal region of T4 -LRB- CD4 -RRB- and requires the intact variable-region-like domain .
7506554	0	gp120	172,177	CD4	38,41	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	human_immunodeficiency_virus_type_1|nmod|START_ENTITY activation|nmod|human_immunodeficiency_virus_type_1 enhancement|nmod|activation properties|dep|enhancement properties|nmod|molecule molecule|compound|END_ENTITY	Costimulatory properties of the human CD4 molecule : enhancement of CD3-induced T cell activation by human_immunodeficiency_virus_type_1 through viral envelope glycoprotein gp120 .
7518527	0	gp120	96,101	CD4	76,79	gp120	CD4	3700	920	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human_immunodeficiency_virus_type_1 .
7522245	0	gp120	0,5	CD4	18,21	gp120	CD4	3700	920	Gene	Gene	ligation|amod|START_ENTITY ligation|nmod|END_ENTITY	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation .
7523525	0	gp120	113,118	CD4	76,79	gp120	CD4	3700	920	Gene	Gene	molecule|amod|START_ENTITY site|nmod|molecule site|compound|END_ENTITY	Enzyme immunoassay -LRB- ELISA -RRB- for the evaluation of antibodies directed to the CD4 receptor-binding site of the HIV gp120 molecule .
7539755	0	gp120	89,94	CD4	14,17	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY induced|nmod|HIV-1 induced|nsubj|Modulation Modulation|nmod|interaction interaction|nummod|END_ENTITY	Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120 .
7540488	0	gp120	94,99	CD4	6,9	gp120	CD4	3700	920	Gene	Gene	epitopes|nmod|START_ENTITY context|nmod|epitopes discriminate|dobj|context discriminate|nsubj|cells cells|compound|END_ENTITY	Human CD4 + T cells can discriminate the molecular and structural context of T epitopes of HIV gp120 and HIV p66 .
7545243	0	gp120	90,95	CD4	50,53	gp120	CD4	3700	920	Gene	Gene	prior|nmod|START_ENTITY requires|dobj|prior requires|nsubj|modulation modulation|nmod|receptors receptors|compound|END_ENTITY	Phorbol_ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules .
7604010	0	gp120	166,171	CD4	19,22	gp120	CD4	3700	920	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|Oligomerization Oligomerization|nmod|END_ENTITY	Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120 .
7642208	0	gp120	75,80	CD4	103,106	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY effect|nmod|HIV-1 effect|nmod|recognition recognition|compound|END_ENTITY	The effect of a single amino_acid substitution within the V3 loop of HIV-1 gp120 on HLA-DR1-restricted CD4 T-cell recognition .
7680610	0	gp120	29,34	CD4	105,108	gp120	CD4	3700	920	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|p56lck p56lck|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Human_immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes .
7686944	0	gp120	99,104	CD4	92,95	gp120	CD4	3700	920	Gene	Gene	affected|nmod|START_ENTITY affected|nmod|attachment attachment|nmod|END_ENTITY	Identification of a new neutralizing epitope conformationally affected by the attachment of CD4 to gp120 .
7688820	0	gp120	193,198	CD4	108,111	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	change|nmod|START_ENTITY conferred|nmod|change conferred|nsubjpass|Resistance Resistance|nmod|escape escape|acl|mutant mutant|nmod|antibodies antibodies|nummod|END_ENTITY	Resistance of a human serum-selected human_immunodeficiency_virus_type_1 escape mutant to neutralization by CD4 binding site monoclonal antibodies is conferred by a single amino_acid change in gp120 .
7811011	0	gp120	166,171	CD4	180,183	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	glycoprotein|appos|START_ENTITY binding|nmod|glycoprotein inhibit|xcomp|binding inhibit|nmod|receptor receptor|compound|END_ENTITY	Assays to detect and characterize human_immunodeficiency_virus_type_1 -LRB- HIV-1 -RRB- receptor antagonists , compounds that inhibit binding of the HIV-1 surface glycoprotein , gp120 , to the CD4 receptor on human T lymphocytes .
7831801	0	gp120	83,88	CD4	168,171	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	loop|nmod|START_ENTITY derived|nmod|loop constructs|acl|derived inhibit|nsubj|constructs inhibit|nmod|interaction interaction|nmod|END_ENTITY	Multibranched peptide constructs derived from the V3 loop of envelope glycoprotein gp120 inhibit human_immunodeficiency_virus_type_1_infection through interaction with CD4 .
7876916	0	gp120	55,60	CD4	86,89	gp120	CD4	3700	920	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|receptor receptor|compound|END_ENTITY	Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor .
7902128	0	gp120	30,35	CD4	41,44	gp120	CD4	3700	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|and/or and/or|compound|END_ENTITY	Non-covalent complexes of HIV gp120 with CD4 and/or mAbs enhance activation of gp120-specific T clones and provide intermolecular help for anti-CD4 antibody production .
7903379	0	gp120	127,132	CD4	92,95	gp120	CD4	3700	920	Gene	Gene	HIV|nummod|START_ENTITY lines|nmod|HIV lines|compound|END_ENTITY	Dendritic cells are potent antigen-presenting cells for in vitro induction of primary human CD4 + T-cell lines specific for HIV gp120 .
7904351	0	gp120	58,63	CD4	45,48	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY recognition|nmod|HIV-1 recognition|nmod|chimeras chimeras|nmod|END_ENTITY	The recognition of chimeras of rat and human CD4 by HIV-1 gp120 and by monoclonal antibodies .
7907597	0	gp120	91,96	CD4	43,46	gp120	CD4	3700	920	Gene	Gene	using|dobj|START_ENTITY Targeting|dep|using Targeting|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Targeting of liposomes to cells expressing CD4 using glycosylphosphatidylinositol-anchored gp120 .
7907660	0	gp120	6,11	CD4	76,79	gp120	CD4	3700	920	Gene	Gene	HIV-1|amod|START_ENTITY induce|nsubj|HIV-1 induce|nmod|lymphocytes lymphocytes|compound|END_ENTITY	HIV-1 gp120 and anti-gp120 induce reversible unresponsiveness in peripheral CD4 T lymphocytes .
7914230	0	gp120	81,86	CD4	0,3	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	lymphocytes|nmod|START_ENTITY modulation|nmod|lymphocytes modulation|nummod|END_ENTITY	CD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120 : contribution to the immunosuppression seen in HIV-1_infection by induction of CD4 and CD3 unresponsiveness .
7914230	0	gp120	81,86	CD4	166,169	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	lymphocytes|nmod|START_ENTITY modulation|nmod|lymphocytes modulation|dep|contribution contribution|nmod|immunosuppression immunosuppression|acl|seen seen|nmod|unresponsiveness unresponsiveness|amod|HIV-1_infection HIV-1_infection|nmod|induction induction|nmod|END_ENTITY	CD4 modulation of noninfected human T lymphocytes by HIV-1 envelope glycoprotein gp120 : contribution to the immunosuppression seen in HIV-1_infection by induction of CD4 and CD3 unresponsiveness .
8002012	0	gp120	67,72	CD4	98,101	gp120	CD4	3700	920	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	Construction and characterization of M13 bacteriophages displaying gp120 binding domains of human CD4 .
8035496	0	gp120	106,111	CD4	71,74	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	neutralization|nmod|START_ENTITY neutralization|compound|END_ENTITY	Differential regulation of cellular tropism and sensitivity to soluble CD4 neutralization by the envelope gp120 of human_immunodeficiency_virus_type_1 .
8043225	0	gp120	69,74	CD4	101,104	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY antibodies|nmod|HIV-1 binding|nmod|antibodies inhibits|dobj|binding potentiated|ccomp|inhibits potentiated|nmod|binding binding|compound|END_ENTITY	Heparin specifically inhibits binding of V3 loop antibodies to HIV-1 gp120 , an effect potentiated by CD4 binding .
8178557	0	gp120	94,99	CD4	20,23	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	functions|amod|START_ENTITY showing|nmod|functions peptide|dep|showing peptide|nsubj|effects effects|nmod|CDR3-related CDR3-related|nummod|END_ENTITY	Multiple effects of CD4 CDR3-related peptide derivatives showing anti-HIV-1 activity on HIV-1 gp120 functions .
8349820	0	gp120	206,211	CD4	186,189	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120 .
8416385	0	gp120	83,88	CD4	92,95	gp120	CD4	3700	920	Gene	Gene	START_ENTITY|nmod|binding binding|compound|END_ENTITY	Glycosylation is necessary for the correct folding of human immunodeficiency virus gp120 in CD4 binding .
8474162	0	gp120	45,50	CD4	104,107	gp120	CD4	3700	920	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope gp120 is cleaved after incubation with recombinant soluble CD4 .
8483933	0	gp120	83,88	CD4	127,130	gp120	CD4	3700	920	Gene	Gene	structure|nmod|START_ENTITY structure|dep|recognition recognition|compound|END_ENTITY	Proposed atomic structure of a truncated human immunodeficiency virus glycoprotein gp120 derived by molecular modeling : target CD4 recognition and docking mechanism .
8503188	0	gp120	57,62	CD4	113,116	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	glycoprotein|dobj|START_ENTITY glycoprotein|nmod|END_ENTITY	Conformational perturbation of the envelope glycoprotein gp120 of human_immunodeficiency_virus_type_1 by soluble CD4 and the lectin succinyl Con A .
8649438	0	gp120	77,82	CD4	98,101	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY epitope|nmod|HIV-1 Design|nmod|epitope Design|acl:relcl|binds binds|nmod|+ +|compound|END_ENTITY	Design and synthesis of a highly immunogenic , discontinuous epitope of HIV-1 gp120 which binds to CD4 + ve transfected cells .
8707350	0	gp120	28,33	CD4	49,52	gp120	CD4	3700	920	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nummod|END_ENTITY	HIV-1 envelope glycoprotein gp120 down-regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor-alpha .
8986758	0	gp120	82,87	CD4	42,45	gp120	CD4	3700	920	Gene	Gene	HIV|nummod|START_ENTITY defective|nmod|HIV receptors|acl:relcl|defective receptors|compound|END_ENTITY	Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding .
9010617	0	gp120	131,136	CD4	91,94	gp120	CD4	3700	920	Gene	Gene	model|nmod|START_ENTITY inhibitors|dep|model inhibitors|nmod|virus virus|amod|binding binding|nmod|cells cells|compound|END_ENTITY	Functional design of potential inhibitors of human immunodeficiency virus -LRB- HIV -RRB- binding to CD4 + target cells : a molecular model of gp120 predicts ligand binding .
9110072	0	gp120	0,5	CD4	53,56	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	present|nsubj|START_ENTITY present|nmod|membrane membrane|nmod|cells cells|compound|END_ENTITY	gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals : an immunoelectron microscopic study .
9138296	0	gp120	58,63	CD4	128,131	gp120	CD4	3700	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|dep|CD98 CD98|nmod|cells cells|compound|END_ENTITY	Human_immunodeficiency_virus_type-1 envelope glycoprotein gp120 induces expression of fusion regulatory protein -LRB- FRP -RRB- -1 / CD98 on CD4 + T cells : a possible regulatory mechanism of HIV-induced syncytium formation .
9209479	0	gp120	69,74	CD4	13,16	gp120	CD4	3700	12504(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|depletion depletion|compound|END_ENTITY	Induction of CD4 + T cell depletion in mice doubly transgenic for HIV gp120 and human CD4 .
9268150	0	gp120	67,72	CD4	7,10	gp120	CD4	3700	920	Gene	Gene	improved|nmod|START_ENTITY molecules|nmod|improved molecules|compound|END_ENTITY	Mutant CD4 molecules with improved binding to HIV envelope protein gp120 selected by phage display .
9295204	0	gp120	57,62	CD4	122,125	gp120	CD4	3700	920	Gene	Gene	molecule|nummod|START_ENTITY molecule|acl:relcl|END_ENTITY	HIV_infection of human fetal neural cells is mediated by gp120 binding to a cell membrane-associated molecule that is not CD4 nor galactocerebroside .
9300725	0	gp120	6,11	CD4	43,46	gp120	CD4	3700	920	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|association association|nmod|END_ENTITY	HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4 .
9341758	0	gp120	139,144	CD4	83,86	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|beta beta|nmod|inhibition inhibition|nmod|cell cell|compound|END_ENTITY	Interleukin-2_receptor beta and gamma chain dysregulation during the inhibition of CD4 T cell activation by human_immunodeficiency_virus-1 gp120 .
9621091	0	gp120	161,166	CD4	185,188	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	interaction|nmod|START_ENTITY triggering|nmod|interaction triggering|nmod|END_ENTITY	The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 with cell surface CD4 .
9641677	0	gp120	20,25	CD4	68,71	gp120	CD4	3700	920	Gene	Gene	envelope|amod|START_ENTITY Structure|nmod|envelope glycoprotein|nsubj|Structure glycoprotein|nmod|receptor receptor|compound|END_ENTITY	Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody .
9692951	0	gp120	72,77	CD4	39,42	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	HIV-1|nummod|START_ENTITY bound|nmod|HIV-1 bound|nsubj|studies studies|nmod|conformation conformation|nmod|peptide peptide|compound|END_ENTITY	NMR studies on the conformation of the CD4 36-59 peptide bound to HIV-1 gp120 .
9696823	0	gp120	92,97	CD4	20,23	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of the CD4 and CXCR4 binding properties of human_immunodeficiency_virus_type_1 gp120 by deletion of the first putative alpha-helical conserved structure .
9719434	0	gp120	97,102	CD4	38,41	gp120	CD4	155971(Tax:11676)	920	Gene	Gene	C1|amod|START_ENTITY directed|nmod|C1 directed|nsubj|Inhibition Inhibition|nmod|cells cells|amod|binding binding|nmod|T T|compound|END_ENTITY	Inhibition of HIV-1 rgp120 binding to CD4 + T cells by monoclonal antibodies directed against the gp120 C1 or C4 region .
9721247	0	gp120	23,28	CD4	30,33	gp120	CD4	3700	920	Gene	Gene	HIV|nummod|START_ENTITY HIV|nummod|END_ENTITY	Interactions among HIV gp120 , CD4 , and CXCR4 : dependence on CD4 expression level , gp120 viral origin , conservation of the gp120 COOH - and NH2-termini and V1/V2 and V3 loops , and sensitivity to neutralizing antibodies .
9780207	0	gp120	15,20	CD4	74,77	gp120	CD4	3700	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|compound|END_ENTITY	HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation .
20663531	0	gp120	94,99	CTB	113,116	gp120	CTB	3700	9468	Gene	Gene	loop|amod|START_ENTITY loop|nmod|END_ENTITY	Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold .
10229873	0	gp120	18,23	CXCR4	69,74	gp120	CXCR4	3700	7852	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	T cell-tropic HIV gp120 mediates CD4 and CD8 cell chemotaxis through CXCR4 independent of CD4 : implications for HIV pathogenesis .
10704341	0	gp120	175,180	CXCR4	71,76	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	glycoprotein|appos|START_ENTITY induced|nmod|glycoprotein induced|nsubjpass|apoptosis apoptosis|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human_immunodeficiency_virus_type_1 envelope glycoprotein -LRB- gp120 -RRB- .
10820198	0	gp120	0,5	CXCR4	66,71	gp120	CXCR4	3700	7852	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors .
11356952	0	gp120	79,84	CXCR4	110,115	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|receptor receptor|compound|END_ENTITY	Cooperation of the V1/V2 and V3 domains of human_immunodeficiency_virus_type_1 gp120 for interaction with the CXCR4 receptor .
11462036	0	gp120	47,52	CXCR4	56,61	gp120	CXCR4	3700	7852	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of human_immunodeficiency_virus_type_1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome_c-mediated apoptosis independently of Fas signaling .
11591141	0	gp120	77,82	CXCR4	86,91	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	engagement|nmod|START_ENTITY occurs|nmod|engagement occurs|nmod|END_ENTITY	HIV-1 gp41 six-helix bundle formation occurs rapidly after the engagement of gp120 by CXCR4 in the HIV-1 Env-mediated fusion process .
11591370	0	gp120	78,83	CXCR4	46,51	gp120	CXCR4	3700	7852	Gene	Gene	surface|nmod|START_ENTITY surface|dobj|association association|nmod|END_ENTITY	Evidence for cell surface association between CXCR4 and ganglioside_GM3 after gp120 binding in SupT1 lymphoblastoid cells .
11595336	0	gp120	37,42	CXCR4	119,124	gp120	CXCR4	155971(Tax:11676)	60628(Tax:10116)	Gene	Gene	causes|nsubj|START_ENTITY Evidence|dep|causes Evidence|nmod|receptor receptor|compound|END_ENTITY	Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor .
12368322	0	gp120	88,93	CXCR4	125,130	gp120	CXCR4	3700	7852	Gene	Gene	glycoprotein|amod|START_ENTITY Identification|nmod|glycoprotein Identification|nmod|importance importance|nmod|binding binding|compound|END_ENTITY	Identification of conserved and variable structures in the human immunodeficiency virus gp120 glycoprotein of importance for CXCR4 binding .
12402167	0	gp120	69,74	CXCR4	11,16	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	parallels|nmod|START_ENTITY parallels|nsubj|development development|compound|END_ENTITY	Functional CXCR4 receptor development parallels sensitivity to HIV-1 gp120 in cultured rat astroglial cells but not in cultured rat cortical neurons .
12502809	0	gp120	18,23	CXCR4	41,46	gp120	CXCR4	3700	7852	Gene	Gene	sites|amod|START_ENTITY Identification|nmod|sites Identification|nmod|END_ENTITY	Identification of gp120 binding sites on CXCR4 by using CD4-independent human_immunodeficiency_virus_type_2 Env proteins .
14689450	0	gp120	80,85	CXCR4	23,28	gp120	CXCR4	3700	7852	Gene	Gene	neurotoxicity|amod|START_ENTITY mediates|dobj|neurotoxicity mediates|nsubj|END_ENTITY	The chemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gp120 neurotoxicity in cerebellar granule cells .
15113923	0	gp120	64,69	CXCR4	98,103	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	binding|nmod|START_ENTITY blocks|amod|binding interaction|nsubj|blocks interaction|nmod|coreceptor coreceptor|compound|END_ENTITY	CD4-induced T-20 binding to human_immunodeficiency_virus_type_1 gp120 blocks interaction with the CXCR4 coreceptor .
16400660	0	gp120	36,41	CXCR4	97,102	gp120	CXCR4	155971(Tax:11676)	60628(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|potentiation potentiation|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 gp120 inhibits long-term potentiation via chemokine receptor CXCR4 in rat hippocampal slices .
16553776	0	gp120	6,11	CXCR4	74,79	gp120	CXCR4	3700	60628(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|potentials potentials|nmod|END_ENTITY	HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus .
18850076	0	gp120	87,92	CXCR4	0,5	gp120	CXCR4	3700	7852	Gene	Gene	HIV|nummod|START_ENTITY blocks|nmod|HIV blocks|nsubj|antagonist antagonist|nummod|END_ENTITY	CXCR4 receptor antagonist blocks cardiac myocyte p38 MAP kinase phosphorylation by HIV gp120 .
20835359	0	gp120	19,24	CXCR4	0,5	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	Inhibition|compound|START_ENTITY Inhibition|compound|END_ENTITY	CXCR4 Tropic HIV-1 gp120 Inhibition of SDF-1a-Induced Chemotaxis Requires Lck and is Associated with Cofilin Phosphorylation .
21438014	0	gp120	6,11	CXCR4	51,56	gp120	CXCR4	155971(Tax:11676)	60628(Tax:10116)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|current current|nmod|END_ENTITY	HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia .
22479424	0	gp120	39,44	CXCR4	145,150	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|activation activation|nmod|interactions interactions|nmod|END_ENTITY	X4 Human_immunodeficiency_virus_type_1 gp120 promotes human hepatic stellate cell activation and collagen I expression through interactions with CXCR4 .
24048002	0	gp120	54,59	CXCR4	25,30	gp120	CXCR4	155971(Tax:11676)	7852	Gene	Gene	loop|compound|START_ENTITY recognition|nmod|loop recognition|nmod|END_ENTITY	Molecular recognition of CXCR4 by a dual tropic HIV-1 gp120 V3 loop .
24451118	0	gp120	62,67	CXCR4	84,89	gp120	CXCR4	3700	60628(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|activity activity|compound|END_ENTITY	HSV-mediated p55TNFSR reduces neuropathic_pain induced by HIV gp120 in rats through CXCR4 activity .
9653130	0	gp120	0,5	CXCR4	113,118	gp120	CXCR4	3700	7852	Gene	Gene	glycoproteins|amod|START_ENTITY antagonize|nsubj|glycoproteins antagonize|xcomp|signaling signaling|nmod|END_ENTITY	gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5 .
17522223	0	gp120	90,95	DC-SIGN	30,37	gp120	DC-SIGN	155971(Tax:11676)	30835	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Identification of the optimal DC-SIGN binding site on human_immunodeficiency_virus_type_1 gp120 .
25078297	0	gp120	86,91	IL-10	0,5	gp120	IL-10	3700	3586	Gene	Gene	HIV|nummod|START_ENTITY induced|nmod|HIV neuropathic_pain|acl|induced reduces|dobj|neuropathic_pain reduces|nsubj|END_ENTITY	IL-10 mediated by herpes simplex virus vector reduces neuropathic_pain induced by HIV gp120 combined with ddC in rats .
7511078	0	gp120	12,17	IL-10	26,31	gp120	IL-10	3700	3586	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells ; correlation with the induction of other cytokines .
21850260	0	gp120	13,18	LFA-1	29,34	gp120	LFA-1	3700	3683	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin -LRB- LtxA -RRB- .
24043886	0	gp120	6,11	TLR2	20,24	gp120	TLR2	3700	7097	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	HIV-1 gp120 induces TLR2 - and TLR4-mediated innate immune activation in human female genital epithelium .
26992429	0	gp120	6,11	TLR4	30,34	gp120	TLR4	3700	7099	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	HIV-1 gp120 signaling through TLR4 modulates innate immune activation in human macrophages and the biology of hepatic stellate cells .
11238869	0	gp120	134,139	V1/V2	140,145	gp120	V1/V2	3700	28299	Gene	Gene	loops|amod|START_ENTITY loops|nummod|END_ENTITY	Loss of a single N-linked glycan allows CD4-independent human_immunodeficiency_virus_type_1_infection by altering the position of the gp120 V1/V2 variable loops .
11390601	0	gp120	142,147	V1/V2	56,61	gp120	V1/V2	155971(Tax:11676)	28299	Gene	Gene	affect|nsubj|START_ENTITY isolate|ccomp|affect isolate|nsubj|sites sites|nmod|END_ENTITY	N-linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human_immunodeficiency_virus_type_1 isolate DH12 gp120 affect coreceptor usage and cellular tropism .
15113902	0	gp120	20,25	V1/V2	4,9	gp120	V1/V2	155971(Tax:11676)	28299	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human_immunodeficiency_virus_type_1 isolates to neutralization by antibodies commonly induced upon infection .
16547752	0	gp120	17,22	V1/V2	23,28	gp120	V1/V2	155971(Tax:11676)	28299	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	N-Glycans in the gp120 V1/V2 domain of the HIV-1_strain NL4-3 are indispensable for viral infectivity and resistance against antibody neutralization .
18768967	0	gp120	97,102	V1/V2	18,23	gp120	V1/V2	155971(Tax:11676)	28299	Gene	Gene	Importance|nmod|START_ENTITY Importance|nmod|region region|compound|END_ENTITY	Importance of the V1/V2 loop region of simian-human_immunodeficiency_virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody response .
7533854	0	gp120	100,105	V1/V2	159,164	gp120	V1/V2	3700	28299	Gene	Gene	region|nmod|START_ENTITY epitopes|nmod|region Characterization|nmod|epitopes Characterization|dep|role role|nmod|glycosylation glycosylation|nmod|folding folding|nmod|domain domain|compound|END_ENTITY	Characterization of neutralization epitopes in the V2 region of human_immunodeficiency_virus_type_1 gp120 : role of glycosylation in the correct folding of the V1/V2 domain .
7543586	0	gp120	104,109	V1/V2	19,24	gp120	V1/V2	155971(Tax:11676)	28299	Gene	Gene	epitopes|amod|START_ENTITY exposure|nmod|epitopes structure|nmod|exposure structure|compound|END_ENTITY	Involvement of the V1/V2 variable loop structure in the exposure of human_immunodeficiency_virus_type_1 gp120 epitopes induced by receptor binding .
8139032	0	gp120	132,137	V1/V2	50,55	gp120	V1/V2	155971(Tax:11676)	28299	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|nmod|interaction interaction|nmod|domains domains|compound|END_ENTITY	Evidence for a functional interaction between the V1/V2 and C4 domains of human_immunodeficiency_virus_type_1 envelope_glycoprotein gp120 .
8794361	0	gp120	153,158	V1/V2	137,142	gp120	V1/V2	3700	28299	Gene	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	N-butyldeoxynojirimycin-mediated inhibition of human immunodeficiency virus entry correlates with changes in antibody recognition of the V1/V2 region of gp120 .
9795384	0	gp120	125,130	V1/V2	103,108	gp120	V1/V2	155971(Tax:11676)	28299	Gene	Gene	HIV-1|nummod|START_ENTITY domain|nmod|HIV-1 domain|compound|END_ENTITY	Potent neutralization of primary HIV-1 isolates by antibodies directed against epitopes present in the V1/V2 domain of HIV-1 gp120 .
15579139	0	gp120	49,54	brain-derived_neurotrophic_factor	77,110	gp120	brain-derived neurotrophic factor	3700	627	Gene	Gene	reduces|nsubj|START_ENTITY reduces|nmod|END_ENTITY	Human_immunodeficiency_virus_type_1 glycoprotein gp120 reduces the levels of brain-derived_neurotrophic_factor in vivo : potential implication for neuronal cell death .
10027715	0	gp120	6,11	c-fos	43,48	gp120	c-fos	3700	2353	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	HIV-1 gp120 induces the activation of both c-fos and c-jun immediate-early genes in HEL megakaryocytic cells .
11085902	0	gp120	41,46	corticotropin-releasing_hormone	50,81	gp120	corticotropin-releasing hormone	155971(Tax:11676)	81648(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Stimulating effect of HIV-1 coat protein gp120 on corticotropin-releasing_hormone and arginine_vasopressin in the rat hypothalamus : involvement of nitric_oxide .
11704656	0	gp120	19,24	interleukin-1beta	36,53	gp120	interleukin-1beta	3700	3553	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells : evidence for a role in the mechanism of cell death .
16846840	0	gp120	6,11	mu_opioid_receptor	33,51	gp120	mu opioid receptor	3700	4988	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	HIV-1 gp120 up-regulation of the mu_opioid_receptor in TPA-differentiated HL-60 cells .
7680610	0	gp120	29,34	p56lck	89,95	gp120	p56lck	3700	3932	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Human_immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes .
16873189	0	gp120	58,63	tumor_necrosis_factor-alpha	72,99	gp120	tumor necrosis factor-alpha	3700	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 induces tumor_necrosis_factor-alpha in astrocytes .
7704970	0	gp120	21,26	tumor_necrosis_factor-alpha	95,122	gp120	tumor necrosis factor-alpha	155971(Tax:11676)	7124	Gene	Gene	fragments|amod|START_ENTITY Interaction|nmod|fragments Interaction|dep|requirements requirements|nmod|production production|compound|END_ENTITY	Interaction of HIV-1 gp120 molecule fragments with human monocytes : different requirements for tumor_necrosis_factor-alpha and IL-6 production .
8272872	0	gp130	106,111	APRF	36,40	gp130	APRF	3572	6774	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130 .
26085685	0	gp130	15,20	CD4	34,37	gp130	CD4	3572	920	Gene	Gene	Signaling|compound|START_ENTITY Signaling|nmod|END_ENTITY	Cell-Intrinsic gp130 Signaling on CD4 + T Cells Shapes Long-Lasting Antiviral Immunity .
12182945	0	gp130	44,49	Cardiotrophin-1	0,15	gp130	Cardiotrophin-1	3572	1489	Gene	Gene	endothelin-1|nmod|START_ENTITY stimulates|xcomp|endothelin-1 stimulates|nsubj|END_ENTITY	Cardiotrophin-1 stimulates endothelin-1 via gp130 in vascular endothelial cells .
12386808	0	gp130	60,65	Cdk9	0,4	gp130	Cdk9	3572	1025	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Cdk9 , a member of the cdc2-like family of kinases , binds to gp130 , the receptor of the IL-6 family of cytokines .
11694760	0	gp130	31,36	Ciliary_neurotrophic_factor	0,27	gp130	Ciliary neurotrophic factor	25205(Tax:10116)	25707(Tax:10116)	Gene	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	Ciliary_neurotrophic_factor , a gp130 cytokine , regulates preovulatory surges of luteinizing hormone and prolactin in the rat .
10510402	0	gp130	75,80	IL-6	121,125	gp130	IL-6	3572	3569	Gene	Gene	up-regulation|nmod|START_ENTITY activation|dep|up-regulation path|nmod|activation creates|nsubj|path creates|nmod|END_ENTITY	Novel path to activation of vascular smooth_muscle_cells : up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor .
10779772	0	gp130	47,52	IL-6	0,4	gp130	IL-6	3572	3569	Gene	Gene	stimulation|nmod|START_ENTITY receptor|dobj|stimulation receptor|nsubj|END_ENTITY	IL-6 receptor independent stimulation of human gp130 by viral IL-6 .
10779772	0	gp130	47,52	IL-6	62,66	gp130	IL-6	3572	3569	Gene	Gene	stimulation|nmod|START_ENTITY receptor|dobj|stimulation receptor|nmod|END_ENTITY	IL-6 receptor independent stimulation of human gp130 by viral IL-6 .
10843753	0	gp130	35,40	IL-6	29,33	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY effect|dep|signalling effect|nmod|interleukin-6 interleukin-6|appos|END_ENTITY	The effect of interleukin-6 -LRB- IL-6 -RRB- / gp130 signalling on biliary epithelial cell growth , in vitro .
11072033	0	gp130	15,20	IL-6	92,96	gp130	IL-6	3572	3569	Gene	Gene	Signal|nmod|START_ENTITY Signal|parataxis|enhances enhances|nsubj|protein protein|compound|END_ENTITY	Signal through gp130 activated by soluble interleukin -LRB- IL -RRB- -6 receptor -LRB- R -RRB- and IL-6 or IL-6R / IL-6 fusion protein enhances ex vivo expansion of human peripheral blood-derived hematopoietic progenitors .
11884403	0	gp130	94,99	IL-6	31,35	gp130	IL-6	3572	3569	Gene	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation determines|xcomp|induce determines|nsubj|Shedding Shedding|nmod|receptor receptor|appos|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
11884403	0	gp130	94,99	IL-6	79,83	gp130	IL-6	3572	3569	Gene	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation determines|xcomp|induce determines|dobj|ability ability|nmod|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
12386808	0	gp130	60,65	IL-6	87,91	gp130	IL-6	3572	3569	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|family family|compound|END_ENTITY	Cdk9 , a member of the cdc2-like family of kinases , binds to gp130 , the receptor of the IL-6 family of cytokines .
12562400	0	gp130	181,186	IL-6	49,53	gp130	IL-6	3572	3569	Gene	Gene	the|nmod|START_ENTITY interfering|nmod|the factors|acl|interfering evidence|nmod|factors systemic_juvenile_idiopathic_arthritis|dep|evidence complexes|nmod|systemic_juvenile_idiopathic_arthritis complexes|dep|circulating circulating|dobj|levels levels|nmod|END_ENTITY	High circulating levels of biologically inactive IL-6 / SIL-6 receptor complexes in systemic_juvenile_idiopathic_arthritis : evidence for serum factors interfering with the binding to gp130 .
12817006	0	gp130	117,122	IL-6	157,161	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|complex complex|compound|END_ENTITY	TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex .
1378269	0	gp130	41,46	IL-6	15,19	gp130	IL-6	3572	3569	Gene	Gene	chain|appos|START_ENTITY chain|compound|END_ENTITY	Enhancement of IL-6 receptor beta chain -LRB- gp130 -RRB- expression by IL-6 , IL-1_and_TNF in human epithelial cells .
1378269	0	gp130	41,46	IL-6	62,66	gp130	IL-6	3572	3569	Gene	Gene	chain|appos|START_ENTITY Enhancement|nmod|chain expression|nsubj|Enhancement expression|nmod|END_ENTITY	Enhancement of IL-6 receptor beta chain -LRB- gp130 -RRB- expression by IL-6 , IL-1_and_TNF in human epithelial cells .
1427893	0	gp130	90,95	IL-6	56,60	gp130	IL-6	25205(Tax:10116)	24498(Tax:10116)	Gene	Gene	molecule|appos|START_ENTITY signal|dobj|molecule signal|nsubj|cloning cloning|nmod|END_ENTITY	Molecular cloning and characterization of the rat liver IL-6 signal transducing molecule , gp130 .
14627979	0	gp130	112,117	IL-6	38,42	gp130	IL-6	3572	3569	Gene	Gene	downregulation|nmod|START_ENTITY cascades|nmod|downregulation signaling|dobj|cascades triggered|xcomp|signaling triggered|nsubj|END_ENTITY	Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple_myeloma .
14738765	0	gp130	55,60	IL-6	16,20	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|dobj|START_ENTITY receptor|nsubj|role role|nmod|END_ENTITY	Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress .
14978019	0	gp130	72,77	IL-6	42,46	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	synergizes|amod|START_ENTITY cytokine|dobj|synergizes cytokine|nsubj|mutation mutation|nmod|tyrosine tyrosine|nmod|family family|compound|END_ENTITY	The point mutation of tyrosine 759 of the IL-6 family cytokine receptor gp130 synergizes with HTLV-1 pX in promoting rheumatoid_arthritis-like arthritis .
1542794	0	gp130	28,33	IL-6	4,8	gp130	IL-6	3572	3569	Gene	Gene	transducer|appos|START_ENTITY transducer|compound|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
15895091	0	gp130	54,59	IL-6	81,85	gp130	IL-6	3572	3569	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor .
1617725	0	gp130	125,130	IL-6	82,86	gp130	IL-6	3572	3569	Gene	Gene	transducing|dobj|START_ENTITY transducing|nsubj|signal signal|compound|END_ENTITY	CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 .
17997171	0	gp130	70,75	IL-6	39,43	gp130	IL-6	3572	3569	Gene	Gene	associated|nsubjpass|START_ENTITY polymorphism|parataxis|associated polymorphism|nmod|transducer transducer|compound|END_ENTITY	A non-conservative polymorphism in the IL-6 signal transducer -LRB- IL6ST -RRB- / gp130 is associated with myocardial_infarction in a hypertensive population .
18469182	0	gp130	8,13	IL-6	32,36	gp130	IL-6	3572	3569	Gene	Gene	START_ENTITY|appos|antagonist antagonist|nmod|transsignaling transsignaling|compound|END_ENTITY	Soluble gp130 , an antagonist of IL-6 transsignaling , is elevated in uveitis aqueous_humor .
18593565	0	gp130	74,79	IL-6	52,56	gp130	IL-6	3572	3569	Gene	Gene	subunit|dobj|START_ENTITY subunit|nsubj|cleavage cleavage|nmod|receptor receptor|compound|END_ENTITY	Caspase-mediated cleavage of the signal-transducing IL-6 receptor subunit gp130 .
18802703	0	gp130	83,88	IL-6	111,115	gp130	IL-6	3572	3569	Gene	Gene	activity|nmod|START_ENTITY tocilizumab|nmod|activity Influence|appos|tocilizumab Influence|appos|inhibitor inhibitor|nmod|signaling signaling|compound|END_ENTITY	Influence of humanized anti-IL-6R antibody , tocilizumab on the activity of soluble gp130 , natural inhibitor of IL-6 signaling .
1915266	0	gp130	91,96	IL-6	67,71	gp130	IL-6	3572	3569	Gene	Gene	transducer|appos|START_ENTITY transducer|compound|END_ENTITY	Leukemia_inhibitory_factor receptor is structurally related to the IL-6 signal transducer , gp130 .
19228423	0	gp130	69,74	IL-6	38,42	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|nmod|receptor receptor|compound|END_ENTITY	Point mutation of tyrosine 759 of the IL-6 family cytokine receptor , gp130 , augments collagen-induced_arthritis in DBA/1J mice .
19285962	0	gp130	69,74	IL-6	23,27	gp130	IL-6	3572	3569	Gene	Gene	pools|amod|START_ENTITY depleting|dobj|pools inhibits|advcl|depleting inhibits|dobj|pathway pathway|compound|END_ENTITY	Capsaicin inhibits the IL-6 / STAT3 pathway by depleting intracellular gp130 pools through endoplasmic_reticulum_stress .
20309664	0	gp130	111,116	IL-6	106,110	gp130	IL-6	3572	3569	Gene	Gene	signaling|nsubj|START_ENTITY protein|parataxis|signaling protein|acl:relcl|induces induces|nmod|activation activation|nmod|END_ENTITY	Amyloid-b precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6 / gp130 signaling pathway .
21881215	0	gp130	57,62	IL-6	52,56	gp130	IL-6	3572	3569	Gene	Gene	signaling|nsubj|START_ENTITY strategies|parataxis|signaling strategies|nmod|END_ENTITY	Therapeutic strategies for the clinical blockade of IL-6 / gp130 signaling .
22140267	0	gp130	14,19	IL-6	59,63	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY permits|nsubj|expression permits|dobj|trans-signaling trans-signaling|compound|END_ENTITY	IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling .
2261637	0	gp130	63,68	IL-6	39,43	gp130	IL-6	3572	3569	Gene	Gene	transducer|appos|START_ENTITY transducer|compound|END_ENTITY	Molecular cloning and expression of an IL-6 signal transducer , gp130 .
23218517	0	gp130	31,36	IL-6	26,30	gp130	IL-6	3572	3569	Gene	Gene	receptor|amod|START_ENTITY signaling|nsubj|receptor Influence|parataxis|signaling Influence|nmod|END_ENTITY	Influence of hypothalamic IL-6 / gp130 receptor signaling on the HPA_axis response to chronic stress .
25103368	0	gp130	17,22	IL-6	12,16	gp130	IL-6	3572	3569	Gene	Gene	expression|amod|START_ENTITY reveals|nsubj|expression Analysis|parataxis|reveals Analysis|nmod|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
25481644	0	gp130	86,91	IL-6	81,85	gp130	IL-6	3572	3569	Gene	Gene	transactivation|amod|START_ENTITY transactivation|compound|END_ENTITY	Sphingosine_kinase_1 contributes to leptin-induced STAT3 phosphorylation through IL-6 / gp130 transactivation in oestrogen receptor-negative breast_cancer .
25722214	0	gp130	32,37	IL-6	27,31	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	Cytokines|amod|START_ENTITY Expression|parataxis|Cytokines Expression|nmod|END_ENTITY	Differential Expression of IL-6 / gp130 Cytokines , Jak-STAT Signaling and Neuroprotection After M ller Cell Ablation in a Transgenic Mouse Model .
26716648	0	gp130	96,101	IL-6	91,95	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY mechanisms|dep|inhibition mechanisms|nmod|END_ENTITY	Sonic hedgehog inhibitors prevent colitis-associated_cancer via orchestrated mechanisms of IL-6 / gp130 inhibition , 15-PGDH induction , Bcl-2 abrogation , and tumorsphere inhibition .
7615645	0	gp130	73,78	IL-6	45,49	gp130	IL-6	3572	3569	Gene	Gene	beta-subunit|appos|START_ENTITY beta-subunit|compound|END_ENTITY	Biosynthetic and glycosylation events of the IL-6 receptor beta-subunit , gp130 .
7649255	0	gp130	133,138	IL-6	109,113	gp130	IL-6	3572	3569	Gene	Gene	transducer|appos|START_ENTITY transducer|compound|END_ENTITY	Leucine-58 in the putative 5th helical region of human interleukin _ -LRB- IL -RRB- -6 is important for activation of the IL-6 signal transducer , gp130 .
7689086	0	gp130	73,78	IL-6	49,53	gp130	IL-6	3572	3569	Gene	Gene	transducer|appos|START_ENTITY signal|dobj|transducer signal|nsubj|Preparation Preparation|nmod|antibodies antibodies|nmod|END_ENTITY	Preparation of monoclonal antibodies against the IL-6 signal transducer , gp130 , that can inhibit IL-6-mediated functions .
7812050	0	gp130	39,44	IL-6	57,61	gp130	IL-6	3572	3569	Gene	Gene	Phosphorylation|nmod|START_ENTITY occur|nsubj|Phosphorylation occur|nmod|activation activation|compound|END_ENTITY	Phosphorylation and internalization of gp130 occur after IL-6 activation of Jak2 kinase in hepatocytes .
7857660	0	gp130	52,57	IL-6	63,67	gp130	IL-6	3572	3569	Gene	Gene	form|nmod|START_ENTITY interact|nmod|form signal|ccomp|interact signal|nsubj|receptor receptor|compound|END_ENTITY	LIF and OM directly interact with a soluble form of gp130 , the IL-6 receptor signal transducing subunit .
7875298	0	gp130	28,33	IL-6	93,97	gp130	IL-6	3572	3569	Gene	Gene	half|nmod|START_ENTITY responsible|nsubj|half responsible|nmod|formation formation|nmod|complex complex|nmod|END_ENTITY	The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6_receptor .
8034658	0	gp130	103,108	IL-6	157,161	gp130	IL-6	3572	3569	Gene	Gene	domain|nmod|START_ENTITY region|nmod|domain Identification|nmod|region Identification|nmod|receptor receptor|compound|END_ENTITY	Identification of a region within the cytoplasmic domain of the interleukin-6 -LRB- IL-6 -RRB- signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor .
8360477	0	gp130	38,43	IL-6	15,19	gp130	IL-6	4827	3569	Gene	Gene	signal|dobj|START_ENTITY signal|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction .
8467812	0	gp130	155,160	IL-6	37,41	gp130	IL-6	3572	3569	Gene	Gene	required|nmod|START_ENTITY residues|acl|required dissociation|nmod|residues analysis|dep|dissociation analysis|nmod|receptor receptor|compound|END_ENTITY	Structure-function analysis of human IL-6 receptor : dissociation of amino_acid residues required for IL-6-binding and for IL-6 signal transduction through gp130 .
8580365	0	gp130	93,98	IL-6	72,76	gp130	IL-6	25205(Tax:10116)	24498(Tax:10116)	Gene	Gene	gp80|appos|START_ENTITY oncostatin_M|dep|gp80 oncostatin_M|dobj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
8722639	0	gp130	148,153	IL-6	24,28	gp130	IL-6	3572	3569	Gene	Gene	form|nmod|START_ENTITY antagonistic|nsubjpass|form factor|parataxis|antagonistic factor|nsubj|form form|nmod|receptor receptor|compound|END_ENTITY	The soluble form of the IL-6 receptor -LRB- sIL-6R_alpha -RRB- is a potent growth factor for AIDS-associated Kaposi 's _ sarcoma -LRB- KS -RRB- cells ; the soluble form of gp130 is antagonistic for sIL-6R_alpha-induced AIDS-KS cell growth .
8898103	0	gp130	142,147	IL-6	118,122	gp130	IL-6	3572	3569	Gene	Gene	START_ENTITY|amod|interleukin-6 interleukin-6|dep|important important|nmod|activation activation|nmod|transducer transducer|compound|END_ENTITY	Identification of residues in the putative 5th helical region of human interleukin-6 , important for activation of the IL-6 signal transducer , gp130 .
8921254	0	gp130	31,36	IL-6	99,103	gp130	IL-6	25205(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|dep|component component|acl|used used|nmod|common common|nmod|CNTF/LIF/OSM CNTF/LIF/OSM|compound|END_ENTITY	Characteristic localization of gp130 -LRB- the signal-transducing receptor component used in common for IL-6 / IL-11 / CNTF/LIF/OSM -RRB- in the rat brain .
9112331	0	gp130	78,83	IL-6	23,27	gp130	IL-6	3572	3569	Gene	Gene	receptor|amod|START_ENTITY antibodies|nmod|receptor signalling|nmod|antibodies inhibition|acl|signalling inhibition|nmod|END_ENTITY	Specific inhibition of IL-6 signalling with monoclonal antibodies against the gp130 receptor .
9126968	0	gp130	48,53	IL-6	13,17	gp130	IL-6	3572	3569	Gene	Gene	kinase|amod|START_ENTITY interacting|nmod|kinase signaling|advcl|interacting END_ENTITY|acl|signaling	Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase .
9295319	0	gp130	67,72	IL-6	140,144	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	part|nmod|START_ENTITY mutagenesis|nmod|part leads|nsubj|mutagenesis leads|nmod|identification identification|nmod|sites sites|nmod|END_ENTITY	Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 -LRB- IL-6 -RRB- .
9517481	0	gp130	14,19	IL-6	23,27	gp130	IL-6	25205(Tax:10116)	24498(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of gp130 by IL-6 / soluble IL-6_receptor induces neuronal differentiation .
9684937	0	gp130	60,65	IL-6	14,18	gp130	IL-6	3572	3569	Gene	Gene	mRNAs|amod|START_ENTITY transducer|dobj|mRNAs transducer|nsubj|Expression Expression|nmod|END_ENTITY	Expression of IL-6 , IL-6 receptor and its signal transducer gp130 mRNAs in megakaryocytic cell lines .
9834125	0	gp130	71,76	IL-6	8,12	gp130	IL-6	3572	3569	Gene	Gene	activity|nmod|START_ENTITY potentiates|dobj|activity potentiates|nsubj|receptor receptor|compound|END_ENTITY	Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses .
9834125	0	gp130	71,76	IL-6	80,84	gp130	IL-6	3572	3569	Gene	Gene	START_ENTITY|nmod|responses responses|compound|END_ENTITY	Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses .
9885909	0	gp130	61,66	IL-6	92,96	gp130	IL-6	3572	3569	Gene	Gene	Dimerization|appos|START_ENTITY Dimerization|nmod|cytokines cytokines|nmod|family family|compound|END_ENTITY	Dimerization and activation of the common transducing chain -LRB- gp130 -RRB- of the cytokines of the IL-6 family by mAb .
9933112	0	gp130	14,19	IL-6	45,49	gp130	IL-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|K-7 K-7|compound|END_ENTITY	Activation of gp130 signaling in vivo by the IL-6 super-agonist K-7 / D-6 accelerates repopulation of lymphoid organs after irradiation .
9951579	0	gp130	39,44	IL-6	45,49	gp130	IL-6	3572	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Functional interaction of the gp80 and gp130 IL-6 receptors in human B cell malignancies .
7736792	0	gp130	6,11	IL6ST	35,40	gp130	IL6ST	3572	3572	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human gp130 transducer chain gene -LRB- IL6ST -RRB- is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11 .
10025579	0	gp130	151,156	Interleukin-6	0,13	gp130	Interleukin-6	3572	3569	Gene	Gene	alteration|nmod|START_ENTITY major_depression|dep|alteration decreased|nmod|major_depression decreased|nsubjpass|END_ENTITY	Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major_depression : no alteration of soluble gp130 .
2788034	0	gp130	90,95	Interleukin-6	0,13	gp130	Interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	transducer|appos|START_ENTITY triggers|nmod|transducer triggers|nsubj|END_ENTITY	Interleukin-6 triggers the association of its receptor with a possible signal transducer , gp130 .
8662918	0	gp130	96,101	Interleukin-6	0,13	gp130	Interleukin-6	3572	3569	Gene	Gene	protein|amod|START_ENTITY expressed|nmod|protein expressed|nsubj|family family|amod|END_ENTITY	Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein .
8145046	0	gp130	147,152	Oncostatin_M	0,12	gp130	Oncostatin M	3572	5008	Gene	Gene	transducer|appos|START_ENTITY cells|nmod|transducer proliferation|nmod|cells induce|dobj|proliferation induce|advmod|END_ENTITY	Oncostatin_M , leukemia_inhibitory_factor , and interleukin_6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp130 .
8157624	0	gp130	31,36	Oncostatin_M	0,12	gp130	Oncostatin M	3572	5008	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Oncostatin_M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin_M receptors .
19852956	0	gp130	24,29	Rac1	10,14	gp130	Rac1	16195(Tax:10090)	19353(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Activated Rac1 requires gp130 for Stat3 activation , cell proliferation and migration .
10777583	0	gp130	111,116	SHP2	86,90	gp130	SHP2	3572	5781	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130 .
22754757	0	gp130	37,42	STAT1/3	12,19	gp130	STAT1/3	16195(Tax:10090)	20846;20848	Gene	Gene	sites|nmod|START_ENTITY sites|nummod|END_ENTITY	Mutation of STAT1/3 binding sites in gp130 -LRB- FXXQ -RRB- knock-in mice does not alter hematopoietic stem cell repopulation or self-renewal potential .
10661409	0	gp130	41,46	STAT3	77,82	gp130	STAT3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY Dissection|acl|signaling Dissection|dep|roles roles|nmod|signals signals|amod|END_ENTITY	Dissection of signaling cascades through gp130 in vivo : reciprocal roles for STAT3 - and SHP2-mediated signals in immune responses .
12782602	0	gp130	191,196	STAT3	72,77	gp130	STAT3	3572	6774	Gene	Gene	system|amod|START_ENTITY stimulation|nmod|system mediated|nmod|stimulation mediated|nsubjpass|activation activation|nmod|END_ENTITY	Epidermal_growth_factor_receptor-independent constitutive activation of STAT3 in head_and_neck_squamous_cell_carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin_6 / gp130 cytokine system .
15927449	0	gp130	101,106	STAT3	38,43	gp130	STAT3	3572	6774	Gene	Gene	motifs|nmod|START_ENTITY activation|nmod|motifs activation|nummod|END_ENTITY	Determinants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130 .
16624864	0	gp130	23,28	STAT3	51,56	gp130	STAT3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	dimerization|nmod|START_ENTITY leads|nsubj|dimerization leads|xcomp|constitutive constitutive|dobj|activation activation|nummod|END_ENTITY	Forced dimerization of gp130 leads to constitutive STAT3 activation , cytokine-independent growth , and blockade of differentiation of embryonic stem cells .
18431520	0	gp130	93,98	STAT3	0,5	gp130	STAT3	16157(Tax:10090)	20848(Tax:10090)	Gene	Gene	mice|nummod|START_ENTITY gastric_tumorigenesis|nmod|mice mediate|dobj|gastric_tumorigenesis mediate|nsubj|END_ENTITY	STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric_tumorigenesis in gp130 receptor mutant mice .
19285962	0	gp130	69,74	STAT3	28,33	gp130	STAT3	3572	6774	Gene	Gene	pools|amod|START_ENTITY depleting|dobj|pools inhibits|advcl|depleting inhibits|dobj|pathway pathway|compound|END_ENTITY	Capsaicin inhibits the IL-6 / STAT3 pathway by depleting intracellular gp130 pools through endoplasmic_reticulum_stress .
19885008	0	gp130	106,111	STAT3	44,49	gp130	STAT3	3572	6774	Gene	Gene	Translation|nmod|START_ENTITY Pathway|dep|Translation Pathway|compound|END_ENTITY	Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130 .
19967068	0	gp130	85,90	STAT3	92,97	gp130	STAT3	3572	6774	Gene	Gene	Signaling|amod|START_ENTITY Signaling|compound|END_ENTITY	Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130 / STAT3 Signaling .
25253866	0	gp130	170,175	STAT3	103,108	gp130	STAT3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	Peripheral nerve regeneration and NGF-dependent neurite outgrowth of adult sensory neurons converge on STAT3 phosphorylation downstream of neuropoietic cytokine receptor gp130 .
25481644	0	gp130	86,91	STAT3	51,56	gp130	STAT3	3572	6774	Gene	Gene	transactivation|amod|START_ENTITY contributes|nmod|transactivation contributes|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Sphingosine_kinase_1 contributes to leptin-induced STAT3 phosphorylation through IL-6 / gp130 transactivation in oestrogen receptor-negative breast_cancer .
26848037	0	gp130	8,13	STAT3	84,89	gp130	STAT3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY ameliorates|nsubj|signalling ameliorates|dobj|colitis colitis|nmod|activation activation|compound|END_ENTITY	Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells .
7624343	0	gp130	40,45	STAT3	0,5	gp130	STAT3	3572	6774	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase .
8934572	0	gp130	80,85	STAT3	102,107	gp130	STAT3	4827	6774	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Two signals are necessary for cell proliferation induced by a cytokine receptor gp130 : involvement of STAT3 in anti-apoptosis .
9711940	0	gp130	14,19	STAT3	56,61	gp130	STAT3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY transduces|nsubj|Activation transduces|dobj|signals signals|nmod|END_ENTITY	Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes .
14511121	0	gp130	85,90	Stat3	33,38	gp130	Stat3	3572	6774	Gene	Gene	cytokines|amod|START_ENTITY Induction|nmod|cytokines Induction|nmod|response response|amod|END_ENTITY	Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines .
15292206	0	gp130	36,41	Stat3	60,65	gp130	Stat3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK .
15466183	0	gp130	14,19	Stat3	81,86	gp130	Stat3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY constitutive|nsubj|Inhibition constitutive|dobj|activation activation|nmod|END_ENTITY	Inhibition of gp130 signaling in breast_cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy .
16041381	0	gp130	28,33	Stat3	19,24	gp130	Stat3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling .
19852956	0	gp130	24,29	Stat3	34,39	gp130	Stat3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Activated Rac1 requires gp130 for Stat3 activation , cell proliferation and migration .
22268122	0	gp130	81,86	Stat3	12,17	gp130	Stat3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY emphysema|nmod|mice dissociates|nmod|emphysema dissociates|nsubj|END_ENTITY	Deregulated Stat3 signaling dissociates pulmonary_inflammation from emphysema in gp130 mutant mice .
8612579	0	gp130	90,95	Stat3	118,123	gp130	Stat3	16195(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|essential essential|nmod|activation activation|amod|END_ENTITY	Differentiation and growth_arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation .
9013873	0	gp130	52,57	Vav	0,3	gp130	Vav	3572	7409	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Vav is associated with signal transducing molecules gp130 , Grb2 and Erk2 , and is tyrosine phosphorylated in response to interleukin-6 .
11013126	0	gp130	68,73	cardiotrophin-1	24,39	gp130	cardiotrophin-1	25205(Tax:10116)	29201(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Augmented expression of cardiotrophin-1 and its receptor component , gp130 , in both left and right ventricles after myocardial_infarction in the rat .
11304496	0	gp130	67,72	cardiotrophin-1	129,144	gp130	cardiotrophin-1	25205(Tax:10116)	29201(Tax:10116)	Gene	Gene	resistance|amod|START_ENTITY involved|nmod|resistance involved|nmod|rat rat|acl|treated treated|nmod|END_ENTITY	Induction of JAB/SOCS -1 / SSI-1 and CIS3/SOCS -3 / SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo .
12890930	0	gp130	66,71	ciliary_neurotrophic_factor	35,62	gp130	ciliary neurotrophic factor	3572	1270	Gene	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	Peritoneal fluid concentrations of ciliary_neurotrophic_factor , a gp130 cytokine , in women with endometriosis .
16818888	0	gp130	0,5	ciliary_neurotrophic_factor	106,133	gp130	ciliary neurotrophic factor	16195(Tax:10090)	12803(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary_neurotrophic_factor .
14511121	0	gp130	85,90	interferon-gamma	16,32	gp130	interferon-gamma	3572	3458	Gene	Gene	cytokines|amod|START_ENTITY Induction|nmod|cytokines Induction|nmod|response response|amod|END_ENTITY	Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines .
10427501	0	gp130	18,23	interleukin-6	75,88	gp130	interleukin-6	3572	3569	Gene	Gene	N-terminus|nmod|START_ENTITY critical|nsubj|N-terminus critical|nmod|formation formation|nmod|complex complex|amod|END_ENTITY	The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex .
10482577	0	gp130	58,63	interleukin-6	20,33	gp130	interleukin-6	3572	4961449(Tax:37296)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Human_herpesvirus_8 interleukin-6 -LRB- vIL-6 -RRB- signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6 .
10692570	0	gp130	36,41	interleukin-6	56,69	gp130	interleukin-6	3572	3569	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nmod|END_ENTITY	Different epitopes are required for gp130 activation by interleukin-6 , oncostatin_M and leukemia_inhibitory_factor .
10720531	0	gp130	94,99	interleukin-6	50,63	gp130	interleukin-6	3572	3569	Gene	Gene	expression|amod|START_ENTITY influencing|dobj|expression down-regulates|advcl|influencing down-regulates|dobj|receptors receptors|amod|END_ENTITY	Endotoxin down-regulates monocyte and granulocyte interleukin-6 receptors without influencing gp130 expression in humans .
10777583	0	gp130	111,116	interleukin-6	40,53	gp130	interleukin-6	3572	3569	Gene	Gene	site|nmod|START_ENTITY exerts|nmod|site exerts|dobj|function function|nmod|transduction transduction|amod|END_ENTITY	SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130 .
10843753	0	gp130	35,40	interleukin-6	14,27	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY effect|dep|signalling effect|nmod|END_ENTITY	The effect of interleukin-6 -LRB- IL-6 -RRB- / gp130 signalling on biliary epithelial cell growth , in vitro .
10848977	0	gp130	54,59	interleukin-6	21,34	gp130	interleukin-6	3572	3569	Gene	Gene	homologue|dobj|START_ENTITY homologue|dep|END_ENTITY	Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells .
11121117	0	gp130	8,13	interleukin-6	50,63	gp130	interleukin-6	3572	3569	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|responses responses|amod|END_ENTITY	Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses .
11473581	0	gp130	64,69	interleukin-6	84,97	gp130	interleukin-6	3572	3569	Gene	Gene	START_ENTITY|nmod|signalling signalling|amod|END_ENTITY	Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling .
11884403	0	gp130	94,99	interleukin-6	16,29	gp130	interleukin-6	3572	3569	Gene	Gene	phosphorylation|amod|START_ENTITY induce|dobj|phosphorylation determines|xcomp|induce determines|nsubj|Shedding Shedding|nmod|receptor receptor|amod|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
12403768	0	gp130	94,99	interleukin-6	62,75	gp130	interleukin-6	3572	3569	Gene	Gene	Tyr-759-dependent|nmod|START_ENTITY Tyr-759-dependent|dobj|attenuation attenuation|nmod|signaling signaling|amod|END_ENTITY	SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 .
12630694	0	gp130	47,52	interleukin-6	33,46	gp130	interleukin-6	3572	3569	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Synthetic peptides mimicking the interleukin-6 / gp130 interaction : a two-helix bundle system .
12646580	0	gp130	24,29	interleukin-6	94,107	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY acts|nsubj|protein acts|nmod|inhibitor inhibitor|amod|END_ENTITY	A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor .
1433971	0	gp130	38,43	interleukin-6	5,18	gp130	interleukin-6	3572	3569	Gene	Gene	-RSB-|nsubj|START_ENTITY -RSB-|advcl|-LSB- -LSB-|dobj|transducer transducer|amod|END_ENTITY	-LSB- The interleukin-6 signal transducer , gp130 , functioning in immune , hematopoietic , and neural systems -RSB- .
14672670	0	gp130	74,79	interleukin-6	89,102	gp130	interleukin-6	3572	4961449(Tax:37296)	Gene	Gene	START_ENTITY|nmod|HHV-8 HHV-8|nummod|END_ENTITY	Molecular mechanisms for viral mimicry of a human cytokine : activation of gp130 by HHV-8 interleukin-6 .
1544406	0	gp130	63,68	interleukin-6	73,86	gp130	interleukin-6	3572	3569	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of the interleukin-6-signal transducing protein -LRB- gp130 -RRB- by interleukin-6 and dexamethasone in HepG2 cells .
16274960	0	gp130	116,121	interleukin-6	84,97	gp130	interleukin-6	403545(Tax:9615)	403985(Tax:9615)	Gene	Gene	transducer|dobj|START_ENTITY transducer|nsubj|Identification Identification|nmod|signal signal|nmod|domain domain|nmod|signal signal|amod|END_ENTITY	Identification of a basolateral sorting signal within the cytoplasmic domain of the interleukin-6 signal transducer gp130 .
16367943	0	gp130	63,68	interleukin-6	22,35	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	component|dobj|START_ENTITY component|nsubj|form form|acl|circulating circulating|dobj|receptor receptor|amod|END_ENTITY	A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory_bowel_disease .
16367943	0	gp130	63,68	interleukin-6	84,97	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	component|dobj|START_ENTITY component|nmod|inhibitor inhibitor|amod|END_ENTITY	A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory_bowel_disease .
17058237	0	gp130	47,52	interleukin-6	19,32	gp130	interleukin-6	25205(Tax:10116)	24498(Tax:10116)	Gene	Gene	receptor-dependent|amod|START_ENTITY signaling|nmod|receptor-dependent signaling|amod|END_ENTITY	Bile_acids inhibit interleukin-6 signaling via gp130 receptor-dependent and - independent pathways in rat liver .
18373551	0	gp130	26,31	interleukin-6	55,68	gp130	interleukin-6	3572	3569	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction .
19264784	0	gp130	42,47	interleukin-6	17,30	gp130	interleukin-6	3572	3569	Gene	Gene	Unraveling|nmod|START_ENTITY Unraveling|dobj|binding binding|amod|END_ENTITY	Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6_receptor .
20660911	0	gp130	8,13	interleukin-6	25,38	gp130	interleukin-6	3572	3569	Gene	Gene	regulatess|nsubj|START_ENTITY regulatess|xcomp|END_ENTITY	Soluble gp130 regulatess interleukin-6 in cerebrospinal fluid after subarachnoid_haemorrhage .
21035897	0	gp130	92,97	interleukin-6	60,73	gp130	interleukin-6	3572	3569	Gene	Gene	transducer|dobj|START_ENTITY transducer|nsubj|structure structure|nmod|domain domain|nmod|signal signal|amod|END_ENTITY	The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution .
21944124	0	gp130	8,13	interleukin-6	71,84	gp130	interleukin-6	3572	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|invasion invasion|nmod|manner manner|amod|END_ENTITY	Soluble gp130 regulates prostate_cancer invasion and progression in an interleukin-6 dependent and independent manner .
24504821	0	gp130	55,60	interleukin-6	80,93	gp130	interleukin-6	3572	3569	Gene	Gene	impairs|amod|START_ENTITY signaling|nsubj|impairs signaling|dep|END_ENTITY	The p38-mediated rapid down-regulation of cell surface gp130 expression impairs interleukin-6 signaling in the synovial fluid of juvenile_idiopathic_arthritis patients .
25078695	0	gp130	58,63	interleukin-6	26,39	gp130	interleukin-6	3572	3569	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Human_herpesvirus_8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion_lymphoma and endothelial cells .
26809098	0	gp130	61,66	interleukin-6	22,35	gp130	interleukin-6	3572	3569	Gene	Gene	dimerized|nsubjpass|START_ENTITY signal|ccomp|dimerized signal|nsubj|form form|nmod|family family|amod|END_ENTITY	A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing .
7530500	0	gp130	62,67	interleukin-6	96,109	gp130	interleukin-6	3572	3569	Gene	Gene	START_ENTITY|appos|transducer transducer|nmod|family family|amod|END_ENTITY	Association and activation of Btk and Tec tyrosine kinases by gp130 , a signal transducer of the interleukin-6 family of cytokines .
7713920	0	gp130	59,64	interleukin-6	33,46	gp130	interleukin-6	3572	3569	Gene	Gene	results|amod|START_ENTITY affect|dobj|results affect|dep|Combining Combining|dobj|mutations mutations|nmod|END_ENTITY	Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6_receptor antagonist on human myeloma cells .
7734154	0	gp130	43,48	interleukin-6	91,104	gp130	interleukin-6	3572	3569	Gene	Gene	protein|appos|START_ENTITY regulation|nmod|protein present|nsubj|regulation present|nmod|specific specific|nmod|cytokines cytokines|amod|END_ENTITY	Separate regulation of a membrane protein , gp130 , present in receptor complex specific for interleukin-6 and other functionally related cytokines .
8157624	0	gp130	103,108	interleukin-6	52,65	gp130	interleukin-6	3572	3569	Gene	Gene	expressing|dobj|START_ENTITY behaves|ccomp|expressing behaves|nmod|antagonist antagonist|amod|END_ENTITY	Oncostatin_M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin_M receptors .
8353278	0	gp130	162,167	interleukin-6	21,34	gp130	interleukin-6	3572	3569	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|forms forms|nmod|gp130 gp130|amod|END_ENTITY	Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130 .
8662709	0	gp130	0,5	interleukin-6	65,78	gp130	interleukin-6	3572	3569	Gene	Gene	cross-linking|amod|START_ENTITY sufficient|nsubj|cross-linking sufficient|xcomp|induce induce|dobj|responses responses|amod|END_ENTITY	gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses .
9073325	0	gp130	22,27	interleukin-6	41,54	gp130	interleukin-6	3572	3569	Gene	Gene	shared|nsubjpass|START_ENTITY shared|nmod|family family|amod|END_ENTITY	The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines .
9295319	0	gp130	67,72	interleukin-6	125,138	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	part|nmod|START_ENTITY mutagenesis|nmod|part leads|nsubj|mutagenesis leads|nmod|identification identification|nmod|sites sites|nmod|IL-6 IL-6|amod|END_ENTITY	Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 -LRB- IL-6 -RRB- .
9558387	0	gp130	0,5	interleukin-6	118,131	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|advcl|END_ENTITY	gp130 , the cytokine common signal-transducer of interleukin-6 cytokine family , is downregulated in T cells in vivo by interleukin-6 .
9558387	0	gp130	0,5	interleukin-6	48,61	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|appos|signal-transducer signal-transducer|nmod|family family|amod|END_ENTITY	gp130 , the cytokine common signal-transducer of interleukin-6 cytokine family , is downregulated in T cells in vivo by interleukin-6 .
9616171	0	gp130	2,7	interleukin-6	8,21	gp130	interleukin-6	16195(Tax:10090)	16193(Tax:10090)	Gene	Gene	transducer-dependent|amod|START_ENTITY transducer-dependent|amod|END_ENTITY	A gp130 interleukin-6 transducer-dependent SCID model of human multiple_myeloma .
9712900	0	gp130	34,39	interleukin-6	69,82	gp130	interleukin-6	3572	3569	Gene	Gene	module|nmod|START_ENTITY required|nsubjpass|module required|advcl|signaling signaling|nmod|END_ENTITY	The immunoglobulin-like module of gp130 is required for signaling by interleukin-6 , but not by leukemia_inhibitory_factor .
9794795	0	gp130	110,115	interleukin-6	60,73	gp130	interleukin-6	3572	3569	Gene	Gene	transducing|dobj|START_ENTITY signal|acl|transducing signal|amod|END_ENTITY	Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression .
9883890	0	gp130	107,112	interleukin-6	75,88	gp130	interleukin-6	3572	3569	Gene	Gene	START_ENTITY|amod|protein-2 protein-2|nmod|signal signal|amod|END_ENTITY	Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130 .
12782602	0	gp130	191,196	interleukin_6	177,190	gp130	interleukin 6	3572	3569	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Epidermal_growth_factor_receptor-independent constitutive activation of STAT3 in head_and_neck_squamous_cell_carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin_6 / gp130 cytokine system .
21079661	0	gp130	41,46	leukemia_inhibitory_factor	11,37	gp130	leukemia inhibitory factor	16195(Tax:10090)	16878(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effects of leukemia_inhibitory_factor on gp130 expression and rate of metaphase II development during in vitro maturation of mouse oocyte .
16086584	0	gp130	56,61	madindoline_A	11,24	gp130	madindoline A	3572	270	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of madindoline_A to the extracellular domain of gp130 .
10205167	0	gp130	80,85	oncostatin_M	55,67	gp130	oncostatin M	16195(Tax:10090)	18413(Tax:10090)	Gene	Gene	transducer|amod|START_ENTITY requires|nmod|transducer requires|dobj|action action|nmod|END_ENTITY	Fetal liver development requires a paracrine action of oncostatin_M through the gp130 signal transducer .
10681548	0	gp130	20,25	oncostatin_M	70,82	gp130	oncostatin M	3572	5008	Gene	Gene	site|amod|START_ENTITY Identification|nmod|site involved|nsubj|Identification involved|nmod|response response|compound|END_ENTITY	Identification of a gp130 cytokine receptor critical site involved in oncostatin_M response .
12724316	0	gp130	109,114	oncostatin_M	32,44	gp130	oncostatin M	3572	5008	Gene	Gene	759|nmod|START_ENTITY involves|dobj|759 involves|nsubj|Desensitization Desensitization|acl|signaling signaling|nmod|END_ENTITY	Desensitization of signaling by oncostatin_M in human vascular cells involves cytoplasmic Tyr residue 759 in gp130 but is not mediated by either Src homology 2 domain-containing tyrosine_phosphatase_2_or_suppressor_of_cytokine_signaling_3 .
1324910	0	gp130	32,37	oncostatin_M	47,59	gp130	oncostatin M	3572	5008	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	Interleukin-6 signal transducer gp130 mediates oncostatin_M signaling .
1542794	0	gp130	28,33	oncostatin_M	38,50	gp130	oncostatin M	3572	5008	Gene	Gene	transducer|appos|START_ENTITY transducer|dep|receptor receptor|compound|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
15863389	0	gp130	15,20	oncostatin_M	31,43	gp130	oncostatin M	3572	5008	Gene	Gene	Measurement|nmod|START_ENTITY cytokines|nsubj|Measurement cytokines|dobj|END_ENTITY	Measurement of gp130 cytokines oncostatin_M and IL-6 in gingival crevicular fluid of patients with chronic_periodontitis .
25103368	0	gp130	17,22	oncostatin_M	108,120	gp130	oncostatin M	3572	5008	Gene	Gene	expression|amod|START_ENTITY reveals|nsubj|expression reveals|ccomp|lack lack|dobj|receptor receptor|compound|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
25103368	0	gp130	17,22	oncostatin_M	158,170	gp130	oncostatin M	3572	5008	Gene	Gene	expression|amod|START_ENTITY reveals|nsubj|expression reveals|ccomp|lack lack|xcomp|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
8054483	0	gp130	66,71	oncostatin_M	21,33	gp130	oncostatin M	16195(Tax:10090)	18413(Tax:10090)	Gene	Gene	transducer|appos|START_ENTITY signal|dobj|transducer signal|nsubj|Interactions Interactions|nmod|END_ENTITY	Interactions between oncostatin_M and the IL-6 signal transducer , gp130 .
8580365	0	gp130	93,98	oncostatin_M	10,22	gp130	oncostatin M	25205(Tax:10116)	289747(Tax:10116)	Gene	Gene	gp80|appos|START_ENTITY END_ENTITY|dep|gp80	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
10704821	0	gp130	107,112	stat3	14,19	gp130	stat3	3572	6774	Gene	Gene	cytokines|amod|START_ENTITY DNA|nmod|cytokines DNA|nsubj|Activation Activation|nmod|END_ENTITY	Activation of stat3 and stat1 DNA binding and transcriptional activity in human brain_tumour cell lines by gp130 cytokines .
24839265	0	gp130	61,66	suppressor_of_cytokine_signaling_3	12,46	gp130	suppressor of cytokine signaling 3	16195(Tax:10090)	12702(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Key role of suppressor_of_cytokine_signaling_3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory_arthritis .
8073632	0	gp135	26,31	EV1	65,68	gp135	EV1	1272	11322	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Sequence variation in the gp135 gene of Maedi_visna_virus_strain EV1 .
1360665	0	gp160	163,168	CD4	59,62	gp160	CD4	2028	920	Gene	Gene	vaccine|amod|START_ENTITY given|dobj|vaccine patients|acl|given +|nmod|patients +|compound|END_ENTITY	Enhancement of human immunodeficiency virus -LRB- HIV -RRB- - specific CD4 + and CD8 + cytotoxic T-lymphocyte activities in HIV-infected asymptomatic patients given recombinant gp160 vaccine .
1677023	0	gp160	79,84	CD4	14,17	gp160	CD4	2028	920	Gene	Gene	derived|nmod|START_ENTITY derived|nsubj|Inhibition Inhibition|nmod|activation activation|compound|END_ENTITY	Inhibition of CD4 + T cell activation and adhesion by peptides derived from the gp160 .
1895408	0	gp160	70,75	CD4	48,51	gp160	CD4	2028	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing +|dobj|cells +|nsubj|Disturbance Disturbance|nmod|transport transport|nmod|proteins proteins|nmod|END_ENTITY	Disturbance of nuclear transport of proteins in CD4 + cells expressing gp160 of human immunodeficiency virus .
1968506	0	gp160	104,109	CD4	114,117	gp160	CD4	155971(Tax:11676)	920	Gene	Gene	START_ENTITY|nmod|recognition recognition|compound|END_ENTITY	Anchor sequence-dependent endogenous processing of human_immunodeficiency_virus_1 envelope glycoprotein gp160 for CD4 + T cell recognition .
2190315	0	gp160	79,84	CD4	13,16	gp160	CD4	2028	920	Gene	Gene	vaccine|amod|START_ENTITY +|nmod|vaccine +|nsubj|Induction Induction|nmod|END_ENTITY	Induction of CD4 + human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine .
2243395	0	gp160	95,100	CD4	106,109	gp160	CD4	155971(Tax:11676)	920	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Intracellular interaction of human_immunodeficiency_virus_type_1 -LRB- ARV-2 -RRB- envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane .
2243395	0	gp160	95,100	CD4	148,151	gp160	CD4	155971(Tax:11676)	920	Gene	Gene	interaction|nmod|START_ENTITY blocks|nsubj|interaction blocks|dobj|movement movement|nmod|END_ENTITY	Intracellular interaction of human_immunodeficiency_virus_type_1 -LRB- ARV-2 -RRB- envelope glycoprotein gp160 with CD4 blocks the movement and maturation of CD4 to the plasma membrane .
7504739	0	gp160	43,48	CD4	21,24	gp160	CD4	155971(Tax:11676)	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|nummod|END_ENTITY	Apoptosis induced in CD4 + cells expressing gp160 of human_immunodeficiency_virus_type_1 .
7543487	0	gp160	75,80	CD4	145,148	gp160	CD4	2028	920	Gene	Gene	C-terminus|nmod|START_ENTITY epitope|nmod|C-terminus Attachment|nmod|epitope facilitates|nsubj|Attachment facilitates|advcl|preserving preserving|xcomp|binding binding|nsubj|END_ENTITY	Attachment of an oligopeptide epitope to the C-terminus of recombinant SIV gp160 facilitates the construction of SMAA complexes while preserving CD4 binding .
8099941	0	gp160	85,90	CD4	6,9	gp160	CD4	2028	920	Gene	Gene	vaccine|amod|START_ENTITY responses|nmod|vaccine +|dobj|responses +|nsubj|END_ENTITY	Human CD4 + cytolytic T lymphocyte responses to a human_immunodeficiency_virus_type_1 gp160 subunit vaccine .
8178478	0	gp160	18,23	CD4	68,71	gp160	CD4	155971(Tax:11676)	920	Gene	Gene	START_ENTITY|nmod|HIV_type_1 HIV_type_1|nmod|induction induction|nmod|END_ENTITY	The difference in gp160 and gp120 of HIV_type_1 in the induction of CD4 downregulation preceding single-cell killing .
8661397	0	gp160	22,27	CD4	67,70	gp160	CD4	2028	920	Gene	Gene	anchorage|nmod|START_ENTITY necessary|nsubj|anchorage necessary|xcomp|prevent prevent|dobj|transport transport|compound|END_ENTITY	Membrane anchorage of gp160 is necessary and sufficient to prevent CD4 transport to the cell surface .
8755538	0	gp160	78,83	CD4	98,101	gp160	CD4	155971(Tax:11676)	920	Gene	Gene	processing|amod|START_ENTITY protease|nmod|processing encoding|dobj|protease encoding|nmod|T T|compound|END_ENTITY	Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4 + T lymphocytes .
18485543	0	gp160	24,29	env	20,23	gp160	env	155971(Tax:11676)	155971(Tax:11676)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Modifying the HIV-1 env gp160 gene to improve pDNA vaccine-elicited cell-mediated immune responses .
8811049	0	gp160	6,11	transforming_growth_factor-beta	20,51	gp160	transforming growth factor-beta	155971(Tax:11676)	7040	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	HIV-1 gp160 induces transforming_growth_factor-beta production in human PBMC .
10473580	0	gp180	76,81	CD8	65,68	gp180	CD8	5788	925	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|class class|acl:relcl|molecule molecule|nmod|END_ENTITY	The nonclassical class I molecule CD1d associates with the novel CD8 ligand gp180 on intestinal epithelial cells .
11890713	0	gp180	62,67	CD8	78,81	gp180	CD8	5788	925	Gene	Gene	glycoprotein|appos|START_ENTITY binds|nsubj|glycoprotein binds|nmod|END_ENTITY	A non-class I MHC intestinal epithelial surface glycoprotein , gp180 , binds to CD8 .
9329971	0	gp180	24,29	CD8	39,42	gp180	CD8	5788	925	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Defective expression of gp180 , a novel CD8 ligand on intestinal epithelial cells , in inflammatory_bowel_disease .
10702280	0	gp330	17,22	megalin	8,15	gp330	megalin	29216(Tax:10116)	29216(Tax:10116)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of megalin -LRB- gp330 -RRB- in transcytosis of thyroglobulin by thyroid cells .
10477563	0	gp34	27,31	OX40	37,41	gp34	OX40	7292	7293	Gene	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Intracellular signaling of gp34 , the OX40 ligand : induction of c-jun and c-fos mRNA expression through gp34 upon binding of its receptor , OX40 .
11071109	0	gp34	36,40	OX40	14,18	gp34	OX40	7292	7293	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Expression Expression|nmod|END_ENTITY	Expression of OX40 and OX40 ligand -LRB- gp34 -RRB- in the normal and myasthenic thymus .
11346458	0	gp34	14,18	OX40	20,24	gp34	OX40	7292	7293	Gene	Gene	START_ENTITY|appos|ligand ligand|compound|END_ENTITY	Expression of gp34 -LRB- OX40 ligand -RRB- and OX40 on human T cell clones .
10477563	0	gp34	103,107	c-jun	63,68	gp34	c-jun	7292	3725	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Intracellular signaling of gp34 , the OX40 ligand : induction of c-jun and c-fos mRNA expression through gp34 upon binding of its receptor , OX40 .
10477563	0	gp34	27,31	c-jun	63,68	gp34	c-jun	7292	3725	Gene	Gene	signaling|nmod|START_ENTITY signaling|dep|induction induction|nmod|expression expression|amod|END_ENTITY	Intracellular signaling of gp34 , the OX40 ligand : induction of c-jun and c-fos mRNA expression through gp34 upon binding of its receptor , OX40 .
10776788	0	gp36	28,32	P45	82,85	gp36	P45	10630	4778	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	HIV-2 transmembrane protein gp36 binds to the putative cellular receptor proteins P45 and P62 .
24932813	0	gp38	48,52	podoplanin	36,46	gp38	podoplanin	10630	10630	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Clinicopathological correlations of podoplanin -LRB- gp38 -RRB- expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk .
1385114	0	gp39	131,135	CD40	84,88	gp39	CD40	959	958	Gene	Gene	form|nmod|START_ENTITY expression|nmod|form ligand|dep|expression ligand|nmod|receptor receptor|compound|END_ENTITY	The human T_cell_antigen_gp39 , a member of the TNF gene family , is a ligand for the CD40 receptor : expression of a soluble form of gp39 with B cell co-stimulatory activity .
16509032	0	gp39	54,58	CD40	41,45	gp39	CD40	959	958	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Classification Classification|nmod|mutations mutations|nmod|END_ENTITY	Classification of mutations in the human CD40 ligand , gp39 , that are associated with X-linked_hyper_IgM_syndrome .
7521888	0	gp39	32,36	CD40	26,30	gp39	CD40	959	958	Gene	Gene	Antibody|appos|START_ENTITY Antibody|nmod|ligand ligand|nmod|END_ENTITY	Antibody to the ligand of CD40 , gp39 , blocks the occurrence of the acute and chronic forms of graft-vs-host_disease .
7532456	0	gp39	43,47	CD40	22,26	gp39	CD40	959	958	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The expansive role of CD40 and its ligand , gp39 , in immunity .
7532462	0	gp39	19,23	CD40	25,29	gp39	CD40	959	958	Gene	Gene	CD40L|appos|START_ENTITY role|nmod|CD40L role|dep|END_ENTITY	The role of CD40L -LRB- gp39 -RRB- / CD40 in T/B cell interaction and primary immunodeficiency .
7678782	0	gp39	17,21	CD40	4,8	gp39	CD40	959	958	Gene	Gene	ligand|appos|START_ENTITY ligand|compound|END_ENTITY	The CD40 ligand , gp39 , is defective in activated T cells from patients with X-linked_hyper-IgM_syndrome .
7689748	0	gp39	61,65	CD40	82,86	gp39	CD40	21939(Tax:10090)	21939(Tax:10090)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Prevention of collagen-induced arthritis with an antibody to gp39 , the ligand for CD40 .
8103067	0	gp39	36,40	CD40	46,50	gp39	CD40	959	958	Gene	Gene	expression|nmod|START_ENTITY regulation|nmod|expression regulation|appos|END_ENTITY	The regulation of the expression of gp39 , the CD40 ligand , on normal and cloned CD4 + T cells .
7554469	0	gp39	12,16	CD40L	18,23	gp39	CD40L	959	959	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of gp39 -LRB- CD40L -RRB- in immunity .
1709867	0	gp40	27,31	CD7	22,25	gp40	CD7	924	924	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Direct involvement of CD7 -LRB- gp40 -RRB- in activation of TcR gamma/delta + T cells .
8566052	0	gp40	14,18	Ep-CAM	85,91	gp40	Ep-CAM	17075(Tax:10090)	4072	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of gp40 , the murine homologue of human epithelial_cell_adhesion_molecule -LRB- Ep-CAM -RRB- , by murine dendritic cells .
8566052	0	gp40	14,18	epithelial_cell_adhesion_molecule	50,83	gp40	epithelial cell adhesion molecule	17075(Tax:10090)	4072	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Expression of gp40 , the murine homologue of human epithelial_cell_adhesion_molecule -LRB- Ep-CAM -RRB- , by murine dendritic cells .
15894583	0	gp49B	39,44	G-CSF	58,63	gp49B	G-CSF	14728(Tax:10090)	12985(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Identification of CCR2 , flotillin , and gp49B genes as new G-CSF targets during neutrophilic differentiation .
8507186	0	gp55	46,50	Erythropoietin_receptor	0,23	gp55	Erythropoietin receptor	27020	2057	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Erythropoietin_receptor binds to Friend virus gp55 through other membrane components .
2161534	0	gp55	47,51	erythropoietin_receptor	71,94	gp55	erythropoietin receptor	27020	13857(Tax:10090)	Gene	Gene	interacts|amod|START_ENTITY spleen_focus-forming_virus|dobj|interacts spleen_focus-forming_virus|nmod|END_ENTITY	Friend spleen_focus-forming_virus glycoprotein gp55 interacts with the erythropoietin_receptor in the endoplasmic reticulum and affects receptor metabolism .
9209415	0	gp55	68,72	erythropoietin_receptor	93,116	gp55	erythropoietin receptor	27020	2057	Gene	Gene	Activation|nmod|START_ENTITY Activation|acl|glycoprotein glycoprotein|nmod|END_ENTITY	Activation of the JAK1-STAT5 pathway by binding of the Friend virus gp55 glycoprotein to the erythropoietin_receptor .
10769163	0	gp600/megalin	80,93	Dab2	26,30	gp600/megalin	Dab2	4036	1601	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin .
19058849	0	gp70	136,140	acinus	17,23	gp70	acinus	133418	22985	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70 .
7615964	0	gp75	34,38	tyrosinase	99,109	gp75	tyrosinase	7306	7299	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Melanocyte differentiation marker gp75 , the brown locus protein , can be regulated independently of tyrosinase and pigmentation .
19103148	0	gp78	25,29	CYP3A4	0,6	gp78	CYP3A4	267	1576	Gene	Gene	ubiquitination|nmod|START_ENTITY ubiquitination|nsubj|END_ENTITY	CYP3A4 ubiquitination by gp78 -LRB- the tumor autocrine_motility_factor_receptor , AMFR -RRB- and CHIP E3 ligases .
19835843	0	gp78	13,17	Hrd1	68,72	gp78	Hrd1	23802(Tax:10090)	74126(Tax:10090)	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Targeting of gp78 for ubiquitin-mediated proteasomal degradation by Hrd1 : cross-talk between E3s in the endoplasmic reticulum .
18037895	0	gp78	21,25	KAI1	67,71	gp78	KAI1	267	3732	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation .
20089858	0	gp78	88,92	KAI1	11,15	gp78	KAI1	267	3732	Gene	Gene	ligase|amod|START_ENTITY proliferation|nmod|ligase role|nmod|proliferation role|nmod|END_ENTITY	A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase .
17681147	0	gp78	22,26	Ufd1	0,4	gp78	Ufd1	267	7353	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase .
11884403	0	gp80	47,51	IL-6	31,35	gp80	IL-6	3570	3569	Gene	Gene	Shedding|appos|START_ENTITY Shedding|nmod|receptor receptor|appos|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
11884403	0	gp80	47,51	IL-6	79,83	gp80	IL-6	3570	3569	Gene	Gene	Shedding|appos|START_ENTITY determines|nsubj|Shedding determines|dobj|ability ability|nmod|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
16956953	0	gp80	104,108	IL-6	124,128	gp80	IL-6	3570	3569	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|complex complex|compound|END_ENTITY	Signal transduction by human_herpesvirus_8 viral interleukin-6 -LRB- vIL-6 -RRB- is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6 .
7524715	0	gp80	40,44	IL-6	26,30	gp80	IL-6	3570	3569	Gene	Gene	molecule|amod|START_ENTITY receptor|dobj|molecule receptor|nsubj|analysis analysis|nmod|END_ENTITY	Epitope analysis of human IL-6 receptor gp80 molecule with monoclonal antibodies .
7537107	0	gp80	200,204	IL-6	185,189	gp80	IL-6	3570	3569	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	IL-6-induced changes in synthesis of alpha 1-acid glycoprotein in human hepatoma Hep3B cells are distinctively regulated by monoclonal antibodies directed against different epitopes of IL-6 receptor -LRB- gp80 -RRB- .
8580365	0	gp80	87,91	IL-6	72,76	gp80	IL-6	171459(Tax:10116)	24498(Tax:10116)	Gene	Gene	oncostatin_M|dep|START_ENTITY oncostatin_M|dobj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
1885602	0	gp91-phox	73,82	CCAAT_displacement_protein	0,26	gp91-phox	CCAAT displacement protein	1536	1523	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	CCAAT_displacement_protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter .
9801155	0	gp91phox	17,25	GATA-3	0,6	gp91phox	GATA-3	1536	2625	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	GATA-3 represses gp91phox gene expression in eosinophil-committed HL-60-C15 cells .
12225397	0	gp91phox	29,37	GM-CSF	0,6	gp91phox	GM-CSF	1536	1437	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	GM-CSF induces expression of gp91phox and stimulates retinoic_acid-induced p47phox expression in human myeloblastic_leukemia cells .
15067074	0	gp91phox	18,26	IFN-gamma	0,9	gp91phox	IFN-gamma	1536	3458	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IFN-gamma induces gp91phox expression in human monocytes via protein_kinase_C-dependent phosphorylation of PU .1 .
22340895	0	gp91phox	110,118	NADPH_oxidase	130,143	gp91phox	NADPH oxidase	1536	1536	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH_oxidase .
26029782	0	gp91phox	108,116	NOX2	102,106	gp91phox	NOX2	66021(Tax:10116)	66021(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Fluorofenidone attenuates oxidative stress and renal_fibrosis in obstructive_nephropathy via blocking NOX2 -LRB- gp91phox -RRB- expression and inhibiting ERK/MAPK signaling pathway .
15260500	0	gp91phox	41,49	p67phox	83,90	gp91phox	p67phox	1536	4688	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the flavoprotein domain of gp91phox upon interaction with N-terminal p67phox -LRB- 1-210 -RRB- and the Rac complex .
20510162	0	gp96	73,77	AIMP1	106,111	gp96	AIMP1	7184	9255	Gene	Gene	expression|amod|START_ENTITY expression|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Toll-like_receptor_4-mediated c-Jun_N-terminal_kinase activation induces gp96 cell surface expression via AIMP1 phosphorylation .
10946285	0	gp96	85,89	CD11b	113,118	gp96	CD11b	7184	3684	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Saturation , competition , and specificity in interaction of heat_shock proteins -LRB- hsp -RRB- gp96 , hsp90 , and hsp70 with CD11b + cells .
11248808	0	gp96	40,44	CD91	0,4	gp96	CD91	7184	4035	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|dep|receptor	CD91 : a receptor for heat_shock protein gp96 .
11290339	0	gp96	50,54	CD91	0,4	gp96	CD91	7184	4035	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	CD91 is a common receptor for heat_shock proteins gp96 , hsp90 , hsp70 , and calreticulin .
12804136	0	gp96	105,109	Granulocyte-macrophage_colony-stimulating_factor	0,48	gp96	Granulocyte-macrophage colony-stimulating factor	22027(Tax:10090)	12981(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor gene-transduced tumor cells combined with tumor-derived gp96 inhibit tumor growth in mice .
22292497	0	gp96	66,70	LDL_receptor	140,152	gp96	LDL receptor	22027(Tax:10090)	16835(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members , including the LDL_receptor and LRP6 .
2842093	0	gp_120	58,64	interleukin_2	11,24	gp 120	interleukin 2	3700	3558	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin_2 and large envelope glycoprotein -LRB- gp_120 -RRB- of human_immunodeficiency_virus -LRB- HIV -RRB- on lymphocyte proliferative responses to cytomegalovirus .
20408777	0	gp_130	32,38	oncostatin_M	16,28	gp 130	oncostatin M	3572	5008	Gene	Gene	cytokine|amod|START_ENTITY END_ENTITY|appos|cytokine	Serum levels of oncostatin_M -LRB- a gp_130 cytokine -RRB- : an inflammatory biomarker in periodontal_disease .
8862395	0	gp_160	101,107	CD4	79,82	gp 160	CD4	2028	920	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing cells|nummod|END_ENTITY	Induction of apoptosis by calmodulin-dependent intracellular Ca2 + elevation in CD4 + cells expressing gp_160 of HIV .
22507226	0	gr-1	66,70	CD11b	59,64	gr-1	CD11b	546644(Tax:10090)	3684	Gene	Gene	splenocytes|amod|START_ENTITY +|dobj|splenocytes +|nsubj|END_ENTITY	Murine_gammaherpesvirus-68 expands , but does not activate , CD11b + gr-1 + splenocytes in vivo .
7558041	0	gracile_axonal_dystrophy	15,39	gad	41,44	gracile axonal dystrophy	gad	22223(Tax:10090)	22223(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the gracile_axonal_dystrophy -LRB- gad -RRB- gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5 .
21557239	0	grainyhead-like_2	4,21	GRHL2	28,33	grainyhead-like 2	GRHL2	79977	79977	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The grainyhead-like_2 gene -LRB- GRHL2 -RRB- single nucleotide polymorphism is not associated with age-related_hearing_impairment in Han Chinese .
17921507	0	grainyhead_like_2	4,21	GRHL2	28,33	grainyhead like 2	GRHL2	79977	79977	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The grainyhead_like_2 gene -LRB- GRHL2 -RRB- , alias TFCP2L3 , is associated with age-related_hearing_impairment .
17343208	0	granulin	8,16	GRN	23,26	granulin	GRN	733645(Tax:9823)	733645(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Porcine granulin gene -LRB- GRN -RRB- : molecular cloning , polymorphism and chromosomal localization .
12588988	0	granulin	18,26	cyclin_T1	42,51	granulin	cyclin T1	2896	904	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The growth factor granulin interacts with cyclin_T1 and modulates P-TEFb-dependent transcription .
17307734	0	granulin-epithelin_precursor	52,80	Cartilage_oligomeric_matrix_protein	0,35	granulin-epithelin precursor	Cartilage oligomeric matrix protein	2896	1311	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	Cartilage_oligomeric_matrix_protein associates with granulin-epithelin_precursor -LRB- GEP -RRB- and potentiates GEP-stimulated chondrocyte proliferation .
9078246	0	granulocyte-colony-stimulating_factor	73,110	Erk-1	153,158	granulocyte-colony-stimulating factor	Erk-1	1440	5595	Gene	Gene	response|nmod|START_ENTITY response|dep|activation activation|nmod|END_ENTITY	cAMP suppresses p21ras and Raf-1 responses but not the Erk-1 response to granulocyte-colony-stimulating_factor : possible Raf-1-independent activation of Erk-1 .
9078246	0	granulocyte-colony-stimulating_factor	73,110	Erk-1	55,60	granulocyte-colony-stimulating factor	Erk-1	1440	5595	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	cAMP suppresses p21ras and Raf-1 responses but not the Erk-1 response to granulocyte-colony-stimulating_factor : possible Raf-1-independent activation of Erk-1 .
11756198	0	granulocyte-colony-stimulating_factor	138,175	FMLP	69,73	granulocyte-colony-stimulating factor	FMLP	1440	2357	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Liposomal amphotericin_B -LRB- AmBisome -RRB- compared with amphotericin_B + / - FMLP induces significantly less in vitro neutrophil aggregation with granulocyte-colony-stimulating_factor / dexamethasone-mobilized allogeneic donor neutrophils .
21539498	0	granulocyte-colony-stimulating_factor	28,65	Flt3	0,4	granulocyte-colony-stimulating factor	Flt3	25610(Tax:10116)	140635(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Flt3 ligand synergizes with granulocyte-colony-stimulating_factor in bone marrow mobilization to improve functional outcome after spinal_cord_injury in the rat .
1705566	0	granulocyte-colony-stimulating_factor	36,73	Tumor_necrosis_factor	0,21	granulocyte-colony-stimulating factor	Tumor necrosis factor	1440	7124	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Tumor_necrosis_factor downregulates granulocyte-colony-stimulating_factor receptor expression on human acute_myeloid_leukemia cells and granulocytes .
16258290	0	granulocyte-colony_stimulating_factor	18,55	G-CSF	11,16	granulocyte-colony stimulating factor	G-CSF	1440	1440	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role for G-CSF -LRB- granulocyte-colony_stimulating_factor -RRB- in the central nervous system .
19494436	0	granulocyte-colony_stimulating_factor	27,64	G-CSF	66,71	granulocyte-colony stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Decreased plasma levels of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- in patients with early Alzheimer 's _ disease .
20043577	0	granulocyte-colony_stimulating_factor	45,82	G-CSF	84,89	granulocyte-colony stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- The plasma levels and diagnostic utility of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage _ - _ colony_stimulating_factor -LRB- GM-CSF -RRB- in patients with I and II stage of breast_cancer -RSB- .
20557950	0	granulocyte-colony_stimulating_factor	78,115	G-CSF	117,122	granulocyte-colony stimulating factor	G-CSF	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Neuroprotective effect of Fn14_deficiency is associated with induction of the granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- pathway in experimental stroke and enhanced by a pathogenic human antiphospholipid antibody .
21999467	0	granulocyte-colony_stimulating_factor	11,48	G-CSF	50,55	granulocyte-colony stimulating factor	G-CSF	25610(Tax:10116)	25610(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- on diabetic_cardiomyopathy in Otsuka Long-Evans Tokushima fatty rats .
7524265	0	granulocyte-colony_stimulating_factor	10,47	G-CSF	49,54	granulocyte-colony stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increased granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- levels in neonates with perinatal complications .
7525437	0	granulocyte-colony_stimulating_factor	7,44	G-CSF	46,51	granulocyte-colony stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Serum granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- levels in elderly patients with infections -RSB- .
7528531	0	granulocyte-colony_stimulating_factor	16,53	G-CSF	55,60	granulocyte-colony stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- in bacterial and viral_infections , and in atypical_pneumonia .
21269949	0	granulocyte-colony_stimulating_factor	40,77	erythropoietin	11,25	granulocyte-colony stimulating factor	erythropoietin	25610(Tax:10116)	24335(Tax:10116)	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of erythropoietin combined with granulocyte-colony_stimulating_factor in the treatment of acute myocardial_infarction in rats -RSB- .
16168442	0	granulocyte-colony_stimulating_factor	60,97	hG-CSF	99,105	granulocyte-colony stimulating factor	hG-CSF	1440	1440	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Transgene expression of biological active recombinant human granulocyte-colony_stimulating_factor -LRB- hG-CSF -RRB- into mouse urine .
9154468	0	granulocyte-colony_stimulating_factor	10,47	interleukin_6	48,61	granulocyte-colony stimulating factor	interleukin 6	1440	3569	Gene	Gene	molecules|amod|START_ENTITY molecules|amod|END_ENTITY	Harlequin granulocyte-colony_stimulating_factor interleukin_6 molecules with bifunctional and antagonistic activities .
8182935	0	granulocyte-macrophage_colony-stimulating_factor	86,134	Bcl-2	14,19	granulocyte-macrophage colony-stimulating factor	Bcl-2	1437	596	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of Bcl-2 expression and apoptosis in acute_myeloblastic_leukaemia cells by granulocyte-macrophage_colony-stimulating_factor .
10089903	0	granulocyte-macrophage_colony-stimulating_factor	115,163	CD34	74,78	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	role|nmod|START_ENTITY progenitors|dep|role progenitors|compound|END_ENTITY	Expansion of granulocyte_colony-stimulating_factor / chemotherapy-mobilized CD34 + hematopoietic progenitors : role of granulocyte-macrophage_colony-stimulating_factor / erythropoietin hybrid protein -LRB- MEN11303 -RRB- and interleukin-15 .
10942362	0	granulocyte-macrophage_colony-stimulating_factor	106,154	CD34	39,43	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	induced|nmod|START_ENTITY blood|acl|induced progenitors|nmod|blood progenitors|nsubj|expression expression|nmod|hematopoietic hematopoietic|compound|END_ENTITY	CXC_chemokine_receptor_3 expression on CD34 -LRB- + -RRB- hematopoietic progenitors from human cord blood induced by granulocyte-macrophage_colony-stimulating_factor : chemotaxis and adhesion induced by its ligands , interferon_gamma-inducible_protein_10 and monokine_induced_by_interferon_gamma .
12542531	0	granulocyte-macrophage_colony-stimulating_factor	216,264	CD34	121,125	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	+|nmod|START_ENTITY +|nsubj|differentiation differentiation|nmod|END_ENTITY	Macrophage colony-stimulating factor in cooperation with transforming_growth_factor-beta1 induces the differentiation of CD34 + hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage_colony-stimulating_factor .
15447861	0	granulocyte-macrophage_colony-stimulating_factor	62,110	CD34	137,141	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	combined|nmod|START_ENTITY combined|advcl|mobilizing mobilizing|dobj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Low-dose granulocyte_colony-stimulating_factor combined with granulocyte-macrophage_colony-stimulating_factor for mobilizing peripheral CD34 + hematopoietic progenitor cells -RSB- .
20860426	0	granulocyte-macrophage_colony-stimulating_factor	59,107	CD34	44,48	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Short-term exposure of umbilical cord blood CD34 + cells to granulocyte-macrophage_colony-stimulating_factor early in culture improves ex vivo expansion of neutrophils .
2478216	0	granulocyte-macrophage_colony-stimulating_factor	163,211	CD34	15,19	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	enhancement|nmod|START_ENTITY Circulation|dep|enhancement Circulation|nmod|cells cells|nummod|END_ENTITY	Circulation of CD34 + hematopoietic stem cells in the peripheral blood of high-dose cyclophosphamide-treated patients : enhancement by intravenous recombinant human granulocyte-macrophage_colony-stimulating_factor .
7519073	0	granulocyte-macrophage_colony-stimulating_factor	30,78	CD34	91,95	granulocyte-macrophage colony-stimulating factor	CD34	574371(Tax:9544)	713858(Tax:9544)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Distribution of receptors for granulocyte-macrophage_colony-stimulating_factor on immature CD34 + bone marrow cells , differentiating monomyeloid progenitors , and mature blood cell subsets .
8543766	0	granulocyte-macrophage_colony-stimulating_factor	27,75	CD34	112,116	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor subunits|nsubj|expression subunits|nmod|cells cells|compound|END_ENTITY	Differential expression of granulocyte-macrophage_colony-stimulating_factor and IL-3 receptor subunits on human CD34 + cells and leukemic cell lines .
9815891	0	granulocyte-macrophage_colony-stimulating_factor	158,206	CD34	84,88	granulocyte-macrophage colony-stimulating factor	CD34	1437	947	Gene	Gene	secrete|dobj|START_ENTITY cancers|acl:relcl|secrete suppress|nmod|cancers presence|acl:relcl|suppress presence|nmod|cells cells|amod|END_ENTITY	Mechanisms of immune suppression in patients with head_and_neck_cancer : presence of CD34 -LRB- + -RRB- cells which suppress immune functions within cancers that secrete granulocyte-macrophage_colony-stimulating_factor .
20357255	0	granulocyte-macrophage_colony-stimulating_factor	14,62	CD8	76,79	granulocyte-macrophage colony-stimulating factor	CD8	1437	925	Gene	Gene	factor|nsubj|START_ENTITY factor|compound|END_ENTITY	Cutting edge : granulocyte-macrophage_colony-stimulating_factor is the major CD8 + T cell-derived licensing factor for dendritic cell activation .
10712390	0	granulocyte-macrophage_colony-stimulating_factor	27,75	Cyclooxygenase-2	0,16	granulocyte-macrophage colony-stimulating factor	Cyclooxygenase-2	1437	5743	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Cyclooxygenase-2 regulates granulocyte-macrophage_colony-stimulating_factor , but not interleukin-8 , production by human vascular cells : role of cAMP .
2064996	0	granulocyte-macrophage_colony-stimulating_factor	73,121	EGR-1	59,64	granulocyte-macrophage colony-stimulating factor	EGR-1	1437	1958	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Posttranscriptional regulation of the zinc finger-encoding EGR-1 gene by granulocyte-macrophage_colony-stimulating_factor in human U-937 monocytic_leukemia cells : involvement of a pertussis toxin-sensitive G protein .
8977530	0	granulocyte-macrophage_colony-stimulating_factor	48,96	Eosinophil_peroxidase	0,21	granulocyte-macrophage colony-stimulating factor	Eosinophil peroxidase	1437	8288	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Eosinophil_peroxidase stimulates the release of granulocyte-macrophage_colony-stimulating_factor from bronchial epithelial cells .
9345066	0	granulocyte-macrophage_colony-stimulating_factor	28,76	Flt3	0,4	granulocyte-macrophage colony-stimulating factor	Flt3	1437	14255(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Flt3 ligand synergizes with granulocyte-macrophage_colony-stimulating_factor or granulocyte_colony-stimulating_factor to mobilize hematopoietic progenitor cells into the peripheral blood of mice .
10231951	0	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	64,70	granulocyte-macrophage colony-stimulating factor	GM-CSF	281095(Tax:9913)	1437	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor on B-1a cell from persistent_lymphocytosis -LRB- PL -RRB- cows and lymphoma cell induced by bovine_leukemia_virus .
11876989	0	granulocyte-macrophage_colony-stimulating_factor	138,186	GM-CSF	188,194	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Mobilization of autologous peripheral blood stem cells by chemotherapy and recombinant granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- -RSB- .
12047622	0	granulocyte-macrophage_colony-stimulating_factor	15,63	GM-CSF	65,71	granulocyte-macrophage colony-stimulating factor	GM-CSF	116630(Tax:10116)	116630(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in pregnancy-enhanced sleep .
1387006	0	granulocyte-macrophage_colony-stimulating_factor	29,77	GM-CSF	79,85	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Biochemical effects of human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on the human neutrophil .
1535090	0	granulocyte-macrophage_colony-stimulating_factor	17,65	GM-CSF	67,73	granulocyte-macrophage colony-stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Up-regulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors in murine peritoneal exudate macrophages by both GM-CSF and IL-3 .
1581405	0	granulocyte-macrophage_colony-stimulating_factor	63,111	GM-CSF	113,119	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A randomized phase-I/II multicenter study of recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- therapy for patients with myelodysplastic_syndromes and a relatively low risk of acute_leukemia .
1772663	0	granulocyte-macrophage_colony-stimulating_factor	26,74	GM-CSF	76,82	granulocyte-macrophage colony-stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The in situ expression of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- mRNA at the maternal-fetal interface .
21515681	0	granulocyte-macrophage_colony-stimulating_factor	63,111	GM-CSF	113,119	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	12981(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- domain induces enhanced antibody and T cell responses .
23565193	0	granulocyte-macrophage_colony-stimulating_factor	60,108	GM-CSF	110,116	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Chimeric_HIV-1_envelope_glycoproteins with potent intrinsic granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- activity .
3071331	0	granulocyte-macrophage_colony-stimulating_factor	38,86	GM-CSF	88,94	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Phase I/II study of recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- in bone_marrow_failure .
3546340	0	granulocyte-macrophage_colony-stimulating_factor	37,85	GM-CSF	87,93	granulocyte-macrophage colony-stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Internalisation and recycling of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor on a murine myelomonocytic_leukemia .
6446568	0	granulocyte-macrophage_colony-stimulating_factor	37,85	GM-CSF	87,93	granulocyte-macrophage colony-stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Secretion and partial degradation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- of mouse L-P3 cells .
6969262	0	granulocyte-macrophage_colony-stimulating_factor	28,76	GM-CSF	78,84	granulocyte-macrophage colony-stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	X-ray-induced production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- by mouse spleen cells in culture .
7577656	0	granulocyte-macrophage_colony-stimulating_factor	38,86	GM-CSF	88,94	granulocyte-macrophage colony-stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interferon-alpha -LRB- IFN-alpha -RRB- inhibits granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- expression at the post-transcriptional level in murine bone marrow stromal cells .
7585565	0	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	64,70	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- activity by suramin and suramin analogues is correlated to interaction with the GM-CSF nucleotide-binding site .
7723402	0	granulocyte-macrophage_colony-stimulating_factor	24,72	GM-CSF	96,102	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	In vivo effect of human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on neutrophil GM-CSF receptors .
8429224	0	granulocyte-macrophage_colony-stimulating_factor	52,100	GM-CSF	102,108	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	An immunoenzyme technique for the identification of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors using digoxigenated-GM-CSF .
8436602	0	granulocyte-macrophage_colony-stimulating_factor	16,64	GM-CSF	66,72	granulocyte-macrophage colony-stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Deregulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor in murine macrophage cell line J774A .1 .
8543141	0	granulocyte-macrophage_colony-stimulating_factor	34,82	GM-CSF	84,90	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Polymorphism at codon 117 of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- gene -RSB- .
8641372	0	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	64,70	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Regulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors in a GM-CSF-dependent human myeloid_leukemia cell line -LRB- AML-193 -RRB- by interleukin-6 .
8871874	0	granulocyte-macrophage_colony-stimulating_factor	14,62	GM-CSF	64,70	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on hepatitis_B vaccination in haemodialysis patients .
9242533	0	granulocyte-macrophage_colony-stimulating_factor	51,99	GM-CSF	101,107	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	responses|nmod|START_ENTITY responses|dep|END_ENTITY	Hematopoietic and lymphopoietic responses in human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor transgenic_mice injected with human GM-CSF .
9376581	0	granulocyte-macrophage_colony-stimulating_factor	10,58	GM-CSF	60,66	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptor exists as a preformed receptor complex that can be activated by GM-CSF , interleukin-3 , or interleukin-5 .
9423810	0	granulocyte-macrophage_colony-stimulating_factor	11,59	GM-CSF	61,67	granulocyte-macrophage colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- on neutrophil kinetics and function in normal human volunteers .
7577656	0	granulocyte-macrophage_colony-stimulating_factor	38,86	Interferon-alpha	0,16	granulocyte-macrophage colony-stimulating factor	Interferon-alpha	12981(Tax:10090)	111654(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interferon-alpha -LRB- IFN-alpha -RRB- inhibits granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- expression at the post-transcriptional level in murine bone marrow stromal cells .
10819777	0	granulocyte-macrophage_colony-stimulating_factor	26,74	Interferon-tau	0,14	granulocyte-macrophage colony-stimulating factor	Interferon-tau	281095(Tax:9913)	317698(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interferon-tau stimulates granulocyte-macrophage_colony-stimulating_factor gene expression in bovine lymphocytes and endometrial stromal cells .
2478229	0	granulocyte-macrophage_colony-stimulating_factor	30,78	Interleukin-1	0,13	granulocyte-macrophage colony-stimulating factor	Interleukin-1	1437	3552	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Interleukin-1 synergizes with granulocyte-macrophage_colony-stimulating_factor on granulocytic colony formation by intermediate production of granulocyte colony-stimulating factor .
1695108	0	granulocyte-macrophage_colony-stimulating_factor	33,81	Interleukin-1_alpha	0,19	granulocyte-macrophage colony-stimulating factor	Interleukin-1 alpha	1437	3552	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1_alpha also induces granulocyte-macrophage_colony-stimulating_factor in immature normal bone marrow cells .
1536949	0	granulocyte-macrophage_colony-stimulating_factor	111,159	Interleukin-1_beta	0,18	granulocyte-macrophage colony-stimulating factor	Interleukin-1 beta	1437	3553	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human blood mononuclear phagocytes is differentially regulated by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , M-CSF , and IL-3 .
3298430	0	granulocyte-macrophage_colony-stimulating_factor	60,108	Interleukin_1	0,13	granulocyte-macrophage colony-stimulating factor	Interleukin 1	1437	3552	Gene	Gene	produce|dobj|START_ENTITY stimulates|advcl|produce stimulates|nsubj|END_ENTITY	Interleukin_1 stimulates human endothelial cells to produce granulocyte-macrophage_colony-stimulating_factor and granulocyte_colony-stimulating_factor .
3491839	0	granulocyte-macrophage_colony-stimulating_factor	68,116	Interleukin_1	0,13	granulocyte-macrophage colony-stimulating factor	Interleukin 1	1437	3552	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin_1 induces cultured human endothelial cell production of granulocyte-macrophage_colony-stimulating_factor .
23696637	0	granulocyte-macrophage_colony-stimulating_factor	61,109	JAK2	152,156	granulocyte-macrophage colony-stimulating factor	KRAS	1437	3845	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|levels levels|nmod|END_ENTITY	CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- signaling via elevated levels of JAK2 and LYN .
8007942	0	granulocyte-macrophage_colony-stimulating_factor	58,106	JAK2	0,4	granulocyte-macrophage colony-stimulating factor	JAK2	1437	3717	Gene	Gene	receptor|nmod|START_ENTITY chain|nmod|receptor associates|nmod|chain associates|nummod|END_ENTITY	JAK2 associates with the beta_c chain of the receptor for granulocyte-macrophage_colony-stimulating_factor , and its activation requires the membrane-proximal region .
8647882	0	granulocyte-macrophage_colony-stimulating_factor	103,151	JAK2	0,4	granulocyte-macrophage colony-stimulating factor	JAK2	12981(Tax:10090)	3717	Gene	Gene	receptor|amod|START_ENTITY essential|nmod|receptor essential|nsubj|END_ENTITY	JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage_colony-stimulating_factor receptor in BA/F3 cells .
9028317	0	granulocyte-macrophage_colony-stimulating_factor	58,106	JAK2	14,18	granulocyte-macrophage colony-stimulating factor	JAK2	1437	3717	Gene	Gene	endothelial|nmod|START_ENTITY endothelial|nsubj|Activation Activation|nmod|END_ENTITY	Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage_colony-stimulating_factor .
9680354	0	granulocyte-macrophage_colony-stimulating_factor	42,90	JAK2	135,139	granulocyte-macrophage colony-stimulating factor	JAK2	1437	3717	Gene	Gene	receptor|amod|START_ENTITY role|nmod|receptor Characterization|nmod|role alpha|nsubj|Characterization alpha|nmod|activation activation|nmod|END_ENTITY	Characterization of the role of the human granulocyte-macrophage_colony-stimulating_factor receptor alpha subunit in the activation of JAK2 and STAT5 .
9464845	0	granulocyte-macrophage_colony-stimulating_factor	26,74	Jak2	94,98	granulocyte-macrophage colony-stimulating factor	Jak2	1437	3717	Gene	Gene	signals|nmod|START_ENTITY transduced|nsubjpass|signals transduced|nmod|kinase kinase|amod|END_ENTITY	Anti-apoptotic signals of granulocyte-macrophage_colony-stimulating_factor are transduced via Jak2 tyrosine kinase in eosinophils .
7520725	0	granulocyte-macrophage_colony-stimulating_factor	59,107	Mast_cell_growth_factor	0,23	granulocyte-macrophage colony-stimulating factor	Mast cell growth factor	12981(Tax:10090)	17311(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Mast_cell_growth_factor -LRB- C-kit_ligand -RRB- in combination with granulocyte-macrophage_colony-stimulating_factor and interleukin-3 : in vivo hemopoietic effects in irradiated mice compared to in vitro effects .
17082615	0	granulocyte-macrophage_colony-stimulating_factor	45,93	Pin1	30,34	granulocyte-macrophage colony-stimulating factor	Pin1	1437	5300	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage_colony-stimulating_factor mRNA stability in T lymphocytes .
11122381	0	granulocyte-macrophage_colony-stimulating_factor	41,89	STAT5	21,26	granulocyte-macrophage colony-stimulating factor	STAT5	12981(Tax:10090)	20850(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|analysis analysis|nmod|END_ENTITY	In vitro analysis of STAT5 activation by granulocyte-macrophage_colony-stimulating_factor .
8407287	0	granulocyte-macrophage_colony-stimulating_factor	38,86	Thymosin_beta_4	0,15	granulocyte-macrophage colony-stimulating factor	Thymosin beta 4	1437	19241(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Thymosin_beta_4 synergizes with human granulocyte-macrophage_colony-stimulating_factor in maintaining bone marrow proliferation .
7512173	0	granulocyte-macrophage_colony-stimulating_factor	106,154	Transforming_growth_factor_alpha	0,32	granulocyte-macrophage colony-stimulating factor	Transforming growth factor alpha	1437	7124	Gene	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|compound|END_ENTITY	Transforming_growth_factor_alpha expression in normal human blood eosinophils : differential regulation by granulocyte-macrophage_colony-stimulating_factor and interleukin-3 .
11754394	0	granulocyte-macrophage_colony-stimulating_factor	114,162	Tumor_necrosis_factor-alpha	0,27	granulocyte-macrophage colony-stimulating factor	Tumor necrosis factor-alpha	1437	7124	Gene	Gene	modulation|nmod|START_ENTITY levels|dep|modulation levels|amod|END_ENTITY	Tumor_necrosis_factor-alpha levels in long-term marrow cultures from patients with aplastic_anemia : modulation by granulocyte-macrophage_colony-stimulating_factor .
1646047	0	granulocyte-macrophage_colony-stimulating_factor	34,82	c-myc	14,19	granulocyte-macrophage colony-stimulating factor	c-myc	1437	4609	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of c-myc expression by granulocyte-macrophage_colony-stimulating_factor in human leukemia cells .
7545467	0	granulocyte-macrophage_colony-stimulating_factor	14,62	cyclosporin_A	113,126	granulocyte-macrophage colony-stimulating factor	cyclosporin A	1437	1161	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	Regulation of granulocyte-macrophage_colony-stimulating_factor and E-selectin expression in endothelial cells by cyclosporin_A and the T-cell transcription factor NFAT .
15447861	0	granulocyte-macrophage_colony-stimulating_factor	62,110	granulocyte_colony-stimulating_factor	10,47	granulocyte-macrophage colony-stimulating factor	granulocyte colony-stimulating factor	1437	1440	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|END_ENTITY	-LSB- Low-dose granulocyte_colony-stimulating_factor combined with granulocyte-macrophage_colony-stimulating_factor for mobilizing peripheral CD34 + hematopoietic progenitor cells -RSB- .
15983807	0	granulocyte-macrophage_colony-stimulating_factor	43,91	hGM-CSF	93,100	granulocyte-macrophage colony-stimulating factor	hGM-CSF	1437	1437	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Process optimization of constitutive human granulocyte-macrophage_colony-stimulating_factor -LRB- hGM-CSF -RRB- expression in Pichia_pastoris fed-batch culture .
22627758	0	granulocyte-macrophage_colony-stimulating_factor	41,89	hGM-CSF	91,98	granulocyte-macrophage colony-stimulating factor	hGM-CSF	1437	1437	Gene	Gene	Production|nmod|START_ENTITY Production|dep|END_ENTITY	Production and characterization of human granulocyte-macrophage_colony-stimulating_factor -LRB- hGM-CSF -RRB- expressed in the oleaginous yeast Yarrowia_lipolytica .
2505890	0	granulocyte-macrophage_colony-stimulating_factor	49,97	interleukin-1	137,150	granulocyte-macrophage colony-stimulating factor	interleukin-1	12981(Tax:10090)	111343(Tax:10090)	Gene	Gene	GM-CSF|dep|START_ENTITY hematopoietic_growth_factor|appos|GM-CSF Effects|nmod|hematopoietic_growth_factor induced|nsubj|Effects induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of hematopoietic_growth_factor -LRB- GM-CSF : granulocyte-macrophage_colony-stimulating_factor -RRB- on thymocyte proliferation induced by interleukin-1 -LRB- IL-1 -RRB- -RSB- .
3139106	0	granulocyte-macrophage_colony-stimulating_factor	123,171	interleukin-1_alpha	14,33	granulocyte-macrophage colony-stimulating factor	interleukin-1 alpha	1437	3552	Gene	Gene	stimulated|nmod|START_ENTITY Production|acl|stimulated Production|nmod|END_ENTITY	Production of interleukin-1_alpha , interleukin-1_beta and tumor_necrosis_factor by human mononuclear cells stimulated with granulocyte-macrophage_colony-stimulating_factor .
10477722	0	granulocyte-macrophage_colony-stimulating_factor	76,124	interleukin-3	135,148	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	chain|nmod|START_ENTITY sequence|nmod|chain sequence|amod|END_ENTITY	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors that is serine-phosphorylated by GM-CSF .
11313280	0	granulocyte-macrophage_colony-stimulating_factor	33,81	interleukin-3	19,32	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	beta-chain|amod|START_ENTITY Down-regulation|dep|beta-chain Down-regulation|nmod|END_ENTITY	Down-regulation of interleukin-3 / granulocyte-macrophage_colony-stimulating_factor receptor beta-chain in BCR-ABL -LRB- + -RRB- human leukemic cells : association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibition .
1696146	0	granulocyte-macrophage_colony-stimulating_factor	80,128	interleukin-3	145,158	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	cyclic_hematopoiesis|nmod|START_ENTITY cyclic_hematopoiesis|amod|END_ENTITY	A comparison of treatment of canine cyclic_hematopoiesis with recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , G-CSF interleukin-3 , and canine G-CSF .
1698795	0	granulocyte-macrophage_colony-stimulating_factor	44,92	interleukin-3	6,19	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	the|nmod|START_ENTITY inhibits|dobj|the inhibits|nsubj|END_ENTITY	Human interleukin-3 inhibits the binding of granulocyte-macrophage_colony-stimulating_factor and interleukin-5 to basophils and strongly enhances their functional activity .
2015572	0	granulocyte-macrophage_colony-stimulating_factor	27,75	interleukin-3	76,89	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	effects|nmod|START_ENTITY /|nsubj|effects /|dobj|protein protein|amod|END_ENTITY	Hematopoietic effects of a granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein .
7579364	0	granulocyte-macrophage_colony-stimulating_factor	25,73	interleukin-3	96,109	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	activated|nmod|START_ENTITY Neutrophils|acl|activated express|nsubj|Neutrophils express|dobj|receptors receptors|nmod|END_ENTITY	Neutrophils activated by granulocyte-macrophage_colony-stimulating_factor express receptors for interleukin-3 which mediate class II expression .
8151315	0	granulocyte-macrophage_colony-stimulating_factor	22,70	interleukin-3	71,84	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Effects of PIXY321 , a granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein , on chemotherapy-induced multilineage myelosuppression in patients with sarcoma .
9490056	0	granulocyte-macrophage_colony-stimulating_factor	82,130	interleukin-3	131,144	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	microheterogeneities|appos|START_ENTITY Characterization|nmod|microheterogeneities Characterization|parataxis|expressed expressed|nsubj|protein protein|amod|END_ENTITY	Characterization of the microheterogeneities of PIXY321 , a genetically engineered granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein expressed in yeast .
9694696	0	granulocyte-macrophage_colony-stimulating_factor	24,72	interleukin-3	73,86	granulocyte-macrophage colony-stimulating factor	interleukin-3	1437	3562	Gene	Gene	beta|amod|START_ENTITY beta|dep|END_ENTITY	Defective expression of granulocyte-macrophage_colony-stimulating_factor / interleukin-3 / interleukin-5 receptor common beta chain in children with acute_myeloid_leukemia associated with respiratory_failure .
8641372	0	granulocyte-macrophage_colony-stimulating_factor	14,62	interleukin-6	150,163	granulocyte-macrophage colony-stimulating factor	interleukin-6	1437	3569	Gene	Gene	receptors|amod|START_ENTITY Regulation|nmod|receptors Regulation|nmod|END_ENTITY	Regulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors in a GM-CSF-dependent human myeloid_leukemia cell line -LRB- AML-193 -RRB- by interleukin-6 .
10712390	0	granulocyte-macrophage_colony-stimulating_factor	27,75	interleukin-8	85,98	granulocyte-macrophage colony-stimulating factor	interleukin-8	1437	3576	Gene	Gene	production|amod|START_ENTITY production|dep|END_ENTITY	Cyclooxygenase-2 regulates granulocyte-macrophage_colony-stimulating_factor , but not interleukin-8 , production by human vascular cells : role of cAMP .
7678512	0	granulocyte-macrophage_colony-stimulating_factor	10,58	interleukin-8	80,93	granulocyte-macrophage colony-stimulating factor	interleukin-8	1437	3576	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of granulocyte-macrophage_colony-stimulating_factor and interleukin-3 on interleukin-8 production by human neutrophils and monocytes .
2104217	0	granulocyte-macrophage_colony-stimulating_factor	89,137	interleukin_1	30,43	granulocyte-macrophage colony-stimulating factor	interleukin 1	1437	3552	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Production Production|nmod|inhibitor inhibitor|amod|END_ENTITY	Production of a 26,000-dalton interleukin_1 inhibitor by human monocytes is regulated by granulocyte-macrophage_colony-stimulating_factor .
2953804	0	granulocyte-macrophage_colony-stimulating_factor	74,122	interleukin_2	13,26	granulocyte-macrophage colony-stimulating factor	interleukin 2	12981(Tax:10090)	16183(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Growth Growth|nmod|line line|amod|interleukin_4-dependent interleukin_4-dependent|nmod:npmod|/ /|nummod|END_ENTITY	Growth of an interleukin_2 / interleukin_4-dependent T cell line induced by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
8425202	0	granulocyte-macrophage_colony-stimulating_factor	127,175	interleukin_2	185,198	granulocyte-macrophage colony-stimulating factor	interleukin 2	1437	3558	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Functional expression of interleukin_2 receptor in a human factor-dependent megakaryoblastic_leukemia cell line : evidence that granulocyte-macrophage_colony-stimulating_factor inhibits interleukin_2 binding to its receptor .
8425202	0	granulocyte-macrophage_colony-stimulating_factor	127,175	interleukin_2	25,38	granulocyte-macrophage colony-stimulating factor	interleukin 2	1437	3558	Gene	Gene	inhibits|nsubj|START_ENTITY evidence|dep|inhibits expression|dep|evidence expression|nmod|receptor receptor|amod|END_ENTITY	Functional expression of interleukin_2 receptor in a human factor-dependent megakaryoblastic_leukemia cell line : evidence that granulocyte-macrophage_colony-stimulating_factor inhibits interleukin_2 binding to its receptor .
8112428	0	granulocyte-macrophage_colony-stimulating_factor	111,159	mast_cell_growth_factor	63,86	granulocyte-macrophage colony-stimulating factor	mast cell growth factor	1437	3562	Gene	Gene	marrow|nmod|START_ENTITY marrow|nmod|END_ENTITY	In vitro response of normal and aplastic_anemia bone marrow to mast_cell_growth_factor and in combination with granulocyte-macrophage_colony-stimulating_factor and interleukin-3 .
7678261	0	granulocyte-macrophage_colony-stimulating_factor	110,158	steel_factor	77,89	granulocyte-macrophage colony-stimulating factor	steel factor	1437	4254	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of immediate-early gene expression in the synergistic effects of steel_factor in combination with granulocyte-macrophage_colony-stimulating_factor or interleukin-3 on proliferation of a human factor-dependent cell line .
10770625	0	granulocyte-macrophage_colony-stimulating_factor	149,197	stem_cell_factor	132,148	granulocyte-macrophage colony-stimulating factor	stem cell factor	12981(Tax:10090)	17311(Tax:10090)	Gene	Gene	transfer|amod|START_ENTITY transfer|compound|END_ENTITY	Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting_cells through stem_cell_factor / granulocyte-macrophage_colony-stimulating_factor gene transfer .
15019293	0	granulocyte-macrophage_colony-stimulating_factor	63,111	stem_cell_factor	113,129	granulocyte-macrophage colony-stimulating factor	stem cell factor	12981(Tax:10090)	17311(Tax:10090)	Gene	Gene	differentiation|nmod|START_ENTITY induction|nmod|differentiation hematopoietic_progenitor_cells|nmod|induction hematopoietic_progenitor_cells|nsubj|END_ENTITY	In vitro induction of inhibitory macrophage differentiation by granulocyte-macrophage_colony-stimulating_factor , stem_cell_factor and interferon-gamma from lineage phenotypes-negative c-kit-positive murine hematopoietic_progenitor_cells .
7532035	0	granulocyte-macrophage_colony-stimulating_factor	171,219	stem_cell_factor	106,122	granulocyte-macrophage colony-stimulating factor	stem cell factor	1437	4254	Gene	Gene	production|amod|START_ENTITY dependency|nmod|production cytokine|xcomp|dependency cytokine|nsubj|interaction interaction|nmod|line line|acl|expressing expressing|dobj|abrogates abrogates|compound|END_ENTITY	Cell-to-cell interaction of cytokine-dependent myeloblastic line constitutively expressing membrane-bound stem_cell_factor abrogates cytokine dependency partially through granulocyte-macrophage_colony-stimulating_factor production .
7693027	0	granulocyte-macrophage_colony-stimulating_factor	77,125	stem_cell_factor	24,40	granulocyte-macrophage colony-stimulating factor	stem cell factor	1437	4254	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of c-kit_ligand -LRB- stem_cell_factor -RRB- in combination with interleukin-5 , granulocyte-macrophage_colony-stimulating_factor , and interleukin-3 , on eosinophil lineage .
9603256	0	granulocyte-macrophage_colony-stimulating_factor	52,100	transforming_growth_factor_beta1	8,40	granulocyte-macrophage colony-stimulating factor	transforming growth factor beta1	12981(Tax:10090)	21803(Tax:10090)	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Seminal transforming_growth_factor_beta1 stimulates granulocyte-macrophage_colony-stimulating_factor production and inflammatory cell recruitment in the murine uterus .
1966932	0	granulocyte-macrophage_colony-stimulating_factor	24,72	tumor_necrosis_factor	117,138	granulocyte-macrophage colony-stimulating factor	tumor necrosis factor	1437	7124	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	Differential effects of granulocyte-macrophage_colony-stimulating_factor and macrophage_colony-stimulating_factor on tumor_necrosis_factor and interleukin-1 production in human monocytes .
1709645	0	granulocyte-macrophage_colony-stimulating_factor	81,129	tumor_necrosis_factor-alpha	14,41	granulocyte-macrophage colony-stimulating factor	tumor necrosis factor-alpha	1437	7124	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Modulation by tumor_necrosis_factor-alpha of human astroglial cell production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
1915559	0	granulocyte-macrophage_colony-stimulating_factor	14,62	tumor_necrosis_factor-alpha	102,129	granulocyte-macrophage colony-stimulating factor	tumor necrosis factor-alpha	1437	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|regulation regulation|nmod|END_ENTITY	Expression of granulocyte-macrophage_colony-stimulating_factor in rheumatoid_arthritis : regulation by tumor_necrosis_factor-alpha .
19590023	0	granulocyte-macrophage_colony-stimulating_factor	72,120	tumor_necrosis_factor-alpha	11,38	granulocyte-macrophage colony-stimulating factor	tumor necrosis factor-alpha	12981(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Macrophage tumor_necrosis_factor-alpha induces epithelial expression of granulocyte-macrophage_colony-stimulating_factor : impact on alveolar epithelial repair .
7516556	0	granulocyte-macrophage_colony_stimulating_factor	48,96	G-CSF	98,103	granulocyte-macrophage colony stimulating factor	G-CSF	1437	1437	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Treatment of drug induced agranulocytosis with granulocyte-macrophage_colony_stimulating_factor -LRB- G-CSF -RRB- -RSB- .
11529909	0	granulocyte-macrophage_colony_stimulating_factor	11,59	GM-CSF	61,67	granulocyte-macrophage colony stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in vivo on cytokine production and proliferation by spleen cells .
17453257	0	granulocyte-macrophage_colony_stimulating_factor	49,97	GM-CSF	99,105	granulocyte-macrophage colony stimulating factor	GM-CSF	1437	1437	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and purification of recombinant human granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- from high cell density cultures of Pichia_pastoris .
17894541	0	granulocyte-macrophage_colony_stimulating_factor	60,108	GM-CSF	110,116	granulocyte-macrophage colony stimulating factor	GM-CSF	1437	1437	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Increased granulocyte-colony_stimulating_factor -LRB- G-CSF -RRB- and granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary_fibrosis .
2276111	0	granulocyte-macrophage_colony_stimulating_factor	22,70	GM-CSF	72,78	granulocyte-macrophage colony stimulating factor	GM-CSF	1437	1437	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The potential role of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in cancer chemotherapy .
3066673	0	granulocyte-macrophage_colony_stimulating_factor	18,66	GM-CSF	68,74	granulocyte-macrophage colony stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of excess granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in mice infected with a GM-CSF retrovirus .
8347851	0	granulocyte-macrophage_colony_stimulating_factor	8,56	GM-CSF	58,64	granulocyte-macrophage colony stimulating factor	GM-CSF	1437	1437	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- after autologous bone marrow transplantation for Hodgkin 's _ disease .
8693443	0	granulocyte-macrophage_colony_stimulating_factor	8,56	GM-CSF	58,64	granulocyte-macrophage colony stimulating factor	GM-CSF	1437	1437	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- in the pathogenesis of adult pulmonary_histiocytosis_X .
9013491	0	granulocyte-macrophage_colony_stimulating_factor	11,59	GM-CSF	61,67	granulocyte-macrophage colony stimulating factor	GM-CSF	12981(Tax:10090)	12981(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of granulocyte-macrophage_colony_stimulating_factor -LRB- GM-CSF -RRB- on biomaterial-associated staphylococcal_infection in mice .
17653623	0	granulocyte-macrophage_colony_stimulating_factor	38,86	hGM-CSF	88,95	granulocyte-macrophage colony stimulating factor	hGM-CSF	1437	1437	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Kinetic studies of constitutive human granulocyte-macrophage_colony_stimulating_factor -LRB- hGM-CSF -RRB- expression in continuous culture of Pichia_pastoris .
18804273	0	granulocyte-macrophage_colony_stimulating_factor	62,110	hGM-CSF	112,119	granulocyte-macrophage colony stimulating factor	hGM-CSF	1437	1437	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Production of transgenic recloned piglets harboring the human granulocyte-macrophage_colony_stimulating_factor -LRB- hGM-CSF -RRB- gene from porcine fetal fibroblasts by nuclear transfer .
6425204	0	granulocyte-macrophage_colony_stimulating_factor	38,86	interferon-gamma	88,104	granulocyte-macrophage colony stimulating factor	interferon-gamma	1437	3458	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Production of five human lymphokines -LRB- granulocyte-macrophage_colony_stimulating_factor , interferon-gamma , interleukin_2 , macrophage cytotoxicity factor and macrophage_migration_inhibitory_factor -RRB- from Con A stimulated lymphocyte cultures in bioreactors .
7475901	0	granulocyte-macrophage_colony_stimulating_factor	19,67	interleukin-3	68,81	granulocyte-macrophage colony stimulating factor	interleukin-3	1437	3562	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Influence of human granulocyte-macrophage_colony_stimulating_factor / interleukin-3 fusion protein -LRB- PIXY321 -RRB- on the hematopoietic_toxicity associated with anti-viral drugs -LRB- zidovudine and didanosine -RRB- in vitro using normal human marrow cells .
7918061	0	granulocyte-macrophage_colony_stimulating_factor	59,107	interleukin-4	18,31	granulocyte-macrophage colony stimulating factor	interleukin-4	1437	3565	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Recombinant human interleukin-4 inhibits the production of granulocyte-macrophage_colony_stimulating_factor by blood mononuclear cells .
16734147	0	granulocyte-macrophage_colony_stimulating_factor	41,89	interleukin-8	91,104	granulocyte-macrophage colony stimulating factor	interleukin-8	1437	3576	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Production of proinflammatory cytokines : granulocyte-macrophage_colony_stimulating_factor , interleukin-8 and interleukin-6 by peripheral blood mononuclear cells of protein energy malnourished children .
6425204	0	granulocyte-macrophage_colony_stimulating_factor	38,86	interleukin_2	106,119	granulocyte-macrophage colony stimulating factor	interleukin 2	1437	3558	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Production of five human lymphokines -LRB- granulocyte-macrophage_colony_stimulating_factor , interferon-gamma , interleukin_2 , macrophage cytotoxicity factor and macrophage_migration_inhibitory_factor -RRB- from Con A stimulated lymphocyte cultures in bioreactors .
17490571	0	granulocyte-macrophage_colony_stimulating_factor	12,60	nuclear_factor-KappaB	64,85	granulocyte-macrophage colony stimulating factor	nuclear factor-KappaB	12981(Tax:10090)	18033(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	-LSB- Effects of granulocyte-macrophage_colony_stimulating_factor on nuclear_factor-KappaB activation in multiple organs of hemorrhage-induced acute_lung_injury in mice -RSB- .
9022262	0	granulocyte-macrophage_colony_stimulating_factor	10,58	prolactin	104,113	granulocyte-macrophage colony stimulating factor	prolactin	116630(Tax:10116)	24683(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of granulocyte-macrophage_colony_stimulating_factor and granulocyte_colony_stimulating_factor on prolactin and adrenocorticotropic hormone secretion in rats : dose - and time-response in vivo studies .
9106172	0	granulocyte-macrophage_colony_stimulating_factor	14,62	rGM-CSF	64,71	granulocyte-macrophage colony stimulating factor	rGM-CSF	1437	116630(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of granulocyte-macrophage_colony_stimulating_factor -LRB- rGM-CSF -RRB- on macrophage function in microbial_disease .
7829234	0	granulocyte-monocyte_colony-stimulating_factor	11,57	GM-CSF	59,65	granulocyte-monocyte colony-stimulating factor	GM-CSF	1437	1437	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of granulocyte-monocyte_colony-stimulating_factor -LRB- GM-CSF -RRB- on expression of adhesion molecules and production of cytokines in blood monocytes and ovarian_cancer-associated macrophages .
3489188	0	granulocyte-monocyte_colony-stimulating_factor	44,90	TNF	18,21	granulocyte-monocyte colony-stimulating factor	TNF	1437	7124	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Recombinant human TNF induces production of granulocyte-monocyte_colony-stimulating_factor .
16721367	0	granulocyte_chemotactic_protein-2	31,64	CXCL6	65,70	granulocyte chemotactic protein-2	CXCL6	6372	6372	Gene	Gene	Production|nmod|START_ENTITY Production|dep|END_ENTITY	Production and upregulation of granulocyte_chemotactic_protein-2 / CXCL6 by IL-1beta and hypoxia in small_cell_lung_cancer .
19682932	0	granulocyte_chemotactic_protein-2	21,54	GCP-2	56,61	granulocyte chemotactic protein-2	GCP-2	281735(Tax:9913)	281735(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of bovine granulocyte_chemotactic_protein-2 -LRB- GCP-2 -RRB- in neutrophils and a mammary epithelial cell line -LRB- MAC-T -RRB- in response to various bacterial cell wall components .
22528488	0	granulocyte_colony-stimulating_factor	31,68	Bv8	13,16	granulocyte colony-stimulating factor	Bv8	1440	60675	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Induction of Bv8 expression by granulocyte_colony-stimulating_factor in CD11b + Gr1 + cells : key role of Stat3 signaling .
10882621	0	granulocyte_colony-stimulating_factor	25,62	CD114	73,78	granulocyte colony-stimulating factor	CD114	1440	1441	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Endotoxin down-modulates granulocyte_colony-stimulating_factor receptor -LRB- CD114 -RRB- on human neutrophils .
22475305	0	granulocyte_colony-stimulating_factor	36,73	CD11b	104,109	granulocyte colony-stimulating factor	CD11b	1440	3684	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	In vivo effect of recombinant human granulocyte_colony-stimulating_factor on neutrophilic expression of CD11b in septic neonates : a randomized controlled trial .
22528488	0	granulocyte_colony-stimulating_factor	31,68	CD11b	72,77	granulocyte colony-stimulating factor	CD11b	1440	3684	Gene	Gene	START_ENTITY|nmod|Gr1 Gr1|amod|END_ENTITY	Induction of Bv8 expression by granulocyte_colony-stimulating_factor in CD11b + Gr1 + cells : key role of Stat3 signaling .
8555479	0	granulocyte_colony-stimulating_factor	15,52	CD14	0,4	granulocyte colony-stimulating factor	CD14	1440	929	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	CD14 + cells in granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow_stroma .
10089903	0	granulocyte_colony-stimulating_factor	13,50	CD34	74,78	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	Expansion|nmod|START_ENTITY Expansion|dep|progenitors progenitors|compound|END_ENTITY	Expansion of granulocyte_colony-stimulating_factor / chemotherapy-mobilized CD34 + hematopoietic progenitors : role of granulocyte-macrophage_colony-stimulating_factor / erythropoietin hybrid protein -LRB- MEN11303 -RRB- and interleukin-15 .
14726397	0	granulocyte_colony-stimulating_factor	70,107	CD34	157,161	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	START_ENTITY|nmod|mobilization mobilization|nmod|cells cells|nummod|END_ENTITY	Use of recombinant human growth hormone -LRB- rhGH -RRB- plus recombinant human granulocyte_colony-stimulating_factor -LRB- rhG-CSF -RRB- for the mobilization and collection of CD34 + cells in poor mobilizers .
1524953	0	granulocyte_colony-stimulating_factor	124,161	CD34	12,16	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	enhancement|nmod|START_ENTITY cells|dep|enhancement stem|dobj|cells stem|csubj|Circulating Circulating|dobj|progenitors progenitors|nummod|+ +|compound|END_ENTITY	Circulating CD34 + hematopoietic progenitors in the harvesting peripheral blood stem cells ; enhancement by recombinant human granulocyte_colony-stimulating_factor .
15257951	0	granulocyte_colony-stimulating_factor	10,47	CD34	87,91	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilizes|nsubj|START_ENTITY mobilizes|dobj|proportion proportion|nmod|CD33 CD33|compound|END_ENTITY	High-dose granulocyte_colony-stimulating_factor mobilizes a higher proportion of early CD34 -LRB- + -RRB- CD33 -LRB- - -RRB- hemopoietic progenitors in children receiving treatment for solid tumors .
15447861	0	granulocyte_colony-stimulating_factor	10,47	CD34	137,141	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	combined|nsubj|START_ENTITY combined|advcl|mobilizing mobilizing|dobj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Low-dose granulocyte_colony-stimulating_factor combined with granulocyte-macrophage_colony-stimulating_factor for mobilizing peripheral CD34 + hematopoietic progenitor cells -RSB- .
15590408	0	granulocyte_colony-stimulating_factor	137,174	CD34	6,10	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	administration|nmod|START_ENTITY predicts|nmod|administration predicts|nsubj|END_ENTITY	Basal CD34 -LRB- + -RRB- cell count predicts peripheral blood progenitor cell mobilization and collection in healthy donors after administration of granulocyte_colony-stimulating_factor .
16532489	0	granulocyte_colony-stimulating_factor	108,145	CD34	51,55	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	treated|nmod|START_ENTITY donors|acl|treated cells|nmod|donors factors|dep|cells factors|acl:relcl|affect affect|dobj|mobilization mobilization|nmod|END_ENTITY	Predictive factors that affect the mobilization of CD34 -LRB- + -RRB- cells in healthy donors treated with recombinant granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
16556705	0	granulocyte_colony-stimulating_factor	118,155	CD34	51,55	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nsubj|application application|nmod|populations populations|compound|END_ENTITY	Characterization and clinical application of human CD34 + stem/progenitor cell populations mobilized into the blood by granulocyte_colony-stimulating_factor .
17313558	0	granulocyte_colony-stimulating_factor	36,73	CD34	0,4	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	administration|nmod|START_ENTITY +|dobj|administration +|nsubj|END_ENTITY	CD34 + dose-driven administration of granulocyte_colony-stimulating_factor after high-dose chemotherapy in lymphoma patients .
18268278	0	granulocyte_colony-stimulating_factor	10,47	CD34	58,62	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilizes|amod|START_ENTITY END_ENTITY|nsubj|mobilizes	Pegylated granulocyte_colony-stimulating_factor mobilizes CD34 + cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte_colony-stimulating_factor .
18484240	0	granulocyte_colony-stimulating_factor	113,150	CD34	94,98	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Phagocytosis of co-developing neutrophil progenitors by dendritic cells in a culture of human CD34 -LRB- + -RRB- cells with granulocyte_colony-stimulating_factor and tumor_necrosis_factor-alpha .
19112912	0	granulocyte_colony-stimulating_factor	52,89	CD34	1,5	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	-LSB- CD34 cells and T cell subsets in recombinant human granulocyte_colony-stimulating_factor primed bone marrow grafts from donors with different characteristics -RSB- .
20633298	0	granulocyte_colony-stimulating_factor	31,68	CD34	6,10	granulocyte colony-stimulating factor	CD34	12985(Tax:10090)	12490(Tax:10090)	Gene	Gene	liver_damage|amod|START_ENTITY mobilized|nmod|liver_damage mobilized|nsubj|cells cells|compound|END_ENTITY	Human CD34 + cells mobilized by granulocyte_colony-stimulating_factor ameliorate radiation-induced liver_damage in mice .
20851866	0	granulocyte_colony-stimulating_factor	112,149	CD34	60,64	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	administration|nmod|START_ENTITY yield|nmod|administration yield|nsubj|Impact Impact|nmod|polymorphisms polymorphisms|nmod|collection collection|compound|END_ENTITY	Impact of constitutional polymorphisms in VCAM1 and CD44 on CD34 + cell collection yield after administration of granulocyte_colony-stimulating_factor to healthy donors .
22683613	0	granulocyte_colony-stimulating_factor	16,53	CD34	132,136	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	START_ENTITY|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|nmod|mobilization mobilization|nmod|hematopoietic hematopoietic|compound|END_ENTITY	Plerixafor plus granulocyte_colony-stimulating_factor versus placebo plus granulocyte_colony-stimulating_factor for mobilization of CD34 -LRB- + -RRB- hematopoietic stem cells in patients with multiple_myeloma and low peripheral blood CD34 -LRB- + -RRB- cell count : results of a subset analysis of a randomized trial .
22683613	0	granulocyte_colony-stimulating_factor	74,111	CD34	132,136	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	START_ENTITY|nmod|mobilization mobilization|nmod|hematopoietic hematopoietic|compound|END_ENTITY	Plerixafor plus granulocyte_colony-stimulating_factor versus placebo plus granulocyte_colony-stimulating_factor for mobilization of CD34 -LRB- + -RRB- hematopoietic stem cells in patients with multiple_myeloma and low peripheral blood CD34 -LRB- + -RRB- cell count : results of a subset analysis of a randomized trial .
7522643	0	granulocyte_colony-stimulating_factor	100,137	CD34	20,24	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilized|nmod|START_ENTITY adults|acl|mobilized +|nmod|adults +|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of CD34 + peripheral blood cells from healthy adults mobilized by recombinant human granulocyte_colony-stimulating_factor .
7542113	0	granulocyte_colony-stimulating_factor	120,157	CD34	29,33	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	treated|nmod|START_ENTITY patients|acl|treated +|nmod|patients +|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of enriched CD34 + cells from healthy volunteers and those from patients treated with chemotherapy plus granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
8616068	0	granulocyte_colony-stimulating_factor	88,125	CD34	63,67	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nsubj|Generation Generation|nmod|cells cells|nmod|cells cells|compound|END_ENTITY	Generation of human natural killer cells from peripheral blood CD34 + cells mobilized by granulocyte_colony-stimulating_factor .
9028941	0	granulocyte_colony-stimulating_factor	101,138	CD34	18,22	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nsubj|status status|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Cycling status of CD34 + cells mobilized into peripheral blood of healthy donors by recombinant human granulocyte_colony-stimulating_factor .
9257810	0	granulocyte_colony-stimulating_factor	77,114	CD34	51,55	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	purified|nmod|START_ENTITY cells|acl|purified cells|nummod|END_ENTITY	Transduction of retrovirus-mediated NeoR gene into CD34 + cells purified from granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized infant and cord blood .
9535034	0	granulocyte_colony-stimulating_factor	16,53	CD34	153,157	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	modified|nsubj|START_ENTITY modified|dobj|transplantation transplantation|nmod|content content|compound|END_ENTITY	T cell-depleted granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- modified allogenic bone marrow transplantation for hematological_malignancy improves graft CD34 + cell content but is associated with delayed pancytopenia .
9603397	0	granulocyte_colony-stimulating_factor	56,93	CD34	29,33	granulocyte colony-stimulating factor	CD34	1440	947	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nsubj|Analysis Analysis|nmod|cells cells|compound|END_ENTITY	Analysis of peripheral blood CD34 + cells mobilized with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- using a long-term culture system .
23319418	0	granulocyte_colony-stimulating_factor	79,116	Carcinoembryonic_antigen-related_cell_adhesion_molecule_1	0,57	granulocyte colony-stimulating factor	Carcinoembryonic antigen-related cell adhesion molecule 1	1440	634	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Carcinoembryonic_antigen-related_cell_adhesion_molecule_1 negatively regulates granulocyte_colony-stimulating_factor production by breast_tumor-associated macrophages that mediate tumor angiogenesis .
21993883	0	granulocyte_colony-stimulating_factor	18,55	ERK1/2	71,77	granulocyte colony-stimulating factor	ERK1/2	1440	5595;5594	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	IL-17A stimulates granulocyte_colony-stimulating_factor production via ERK1/2 but not p38 or JNK in human renal proximal tubular epithelial cells .
10561191	0	granulocyte_colony-stimulating_factor	27,64	Erythropoietin	0,14	granulocyte colony-stimulating factor	Erythropoietin	1440	2056	Gene	Gene	abrogates|amod|START_ENTITY addition|nmod|abrogates addition|compound|END_ENTITY	Erythropoietin addition to granulocyte_colony-stimulating_factor abrogates life-threatening neutropenia and increases peripheral-blood progenitor-cell mobilization after epirubicin , paclitaxel , and cisplatin combination chemotherapy : results of a randomized comparison .
23674093	0	granulocyte_colony-stimulating_factor	67,104	Extracellular_signal-regulated_kinase_2	0,39	granulocyte colony-stimulating factor	Extracellular signal-regulated kinase 2	1440	5594	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase_2 mediates the expression of granulocyte_colony-stimulating_factor in invasive cancer cells .
9166838	0	granulocyte_colony-stimulating_factor	29,66	Flt-3_ligand	0,12	granulocyte colony-stimulating factor	Flt-3 ligand	1440	2323	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|amod|END_ENTITY	Flt-3_ligand synergizes with granulocyte_colony-stimulating_factor to increase neutrophil numbers and to mobilize peripheral blood stem cells with long-term repopulating potential .
10364174	0	granulocyte_colony-stimulating_factor	15,52	G-CSF	54,59	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- with its receptor .
11523133	0	granulocyte_colony-stimulating_factor	44,81	G-CSF	83,88	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- A case of Bellini_duct_carcinoma producing granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- -RSB- .
12040470	0	granulocyte_colony-stimulating_factor	12,49	G-CSF	51,56	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in the post-transplant period .
12456601	0	granulocyte_colony-stimulating_factor	18,55	G-CSF	57,62	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Cyclic changes of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- mRNA in the human follicle during the normal menstrual cycle and immunolocalization of G-CSF protein .
12636092	0	granulocyte_colony-stimulating_factor	11,48	G-CSF	50,55	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Endogenous granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- levels in chemotherapy-induced neutropenia and in neutropenia related with primary_diseases .
1371630	0	granulocyte_colony-stimulating_factor	45,82	G-CSF	84,89	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Chronic congenital_neutropenia treated with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- -RSB- .
1373092	0	granulocyte_colony-stimulating_factor	12,49	G-CSF	51,56	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- levels after allogeneic and autologous bone marrow transplantation : endogenous G-CSF production correlates with myeloid engraftment .
1374055	0	granulocyte_colony-stimulating_factor	28,65	G-CSF	70,75	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rh G-CSF -RRB- on murine resistance against Listeria_monocytogenes .
14510752	0	granulocyte_colony-stimulating_factor	10,47	G-CSF	49,54	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - supported chemotherapy on MR imaging of normal red bone marrow in breast_cancer patients with focal bone metastases .
15644577	0	granulocyte_colony-stimulating_factor	24,61	G-CSF	63,68	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in antithyroid drug-induced agranulocytosis .
16410701	0	granulocyte_colony-stimulating_factor	109,146	G-CSF	148,153	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Two cases of malignant_lymphoma with high fever and C-reactive_protein -LRB- CRP -RRB- elevation after treatment with granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- -RSB- .
18602391	0	granulocyte_colony-stimulating_factor	45,82	G-CSF	84,89	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neuroprotective effects of recombinant human granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in neurodegeneration after optic nerve crush in rats .
2020039	0	granulocyte_colony-stimulating_factor	14,51	G-CSF	53,58	granulocyte colony-stimulating factor	G-CSF	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- upon burn-induced defective neutrophil chemotaxis .
21123967	0	granulocyte_colony-stimulating_factor	39,76	G-CSF	78,83	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Cell cycle-dependent priming action of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- enhances in vitro apoptosis induction by cytarabine and etoposide in leukemia cell lines .
21396452	0	granulocyte_colony-stimulating_factor	40,77	G-CSF	79,84	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Soluble periplasmic production of human granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in Pseudomonas_fluorescens .
24316388	0	granulocyte_colony-stimulating_factor	45,82	G-CSF	84,89	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neuroprotective effects of recombinant human granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- in a rat model of anterior_ischemic_optic_neuropathy -LRB- rAION -RRB- .
3257647	0	granulocyte_colony-stimulating_factor	33,70	G-CSF	72,77	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of purified human native granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on proliferation of blast progenitors in acute_myeloblastic_leukemia .
6602806	0	granulocyte_colony-stimulating_factor	34,71	G-CSF	73,78	granulocyte colony-stimulating factor	G-CSF	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Proliferative effects of purified granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on normal mouse hemopoietic cells .
7507094	0	granulocyte_colony-stimulating_factor	22,59	G-CSF	61,66	granulocyte colony-stimulating factor	G-CSF	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Therapeutic effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on the protection against Listeria_infection in SCID mice .
7530467	0	granulocyte_colony-stimulating_factor	75,112	G-CSF	114,119	granulocyte colony-stimulating factor	G-CSF	12985(Tax:10090)	12985(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- expression in bone marrow and fractionated marrow cell populations by interleukin_3 -LRB- IL-3 -RRB- : IL-3-mediated positive feedback mechanisms of granulopoiesis .
7543781	0	granulocyte_colony-stimulating_factor	10,47	G-CSF	49,54	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on chemotherapy-induced oral_mucositis .
7545505	0	granulocyte_colony-stimulating_factor	24,61	G-CSF	63,68	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- determined by a highly-sensitive chemiluminescent immunoassay during the clinical course of subacute_thyroiditis .
7581097	0	granulocyte_colony-stimulating_factor	6,43	G-CSF	45,50	granulocyte colony-stimulating factor	G-CSF	1440	1440	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- levels after allogeneic T_cell-depleted marrow transplantation .
9164511	0	granulocyte_colony-stimulating_factor	14,51	G-CSF	53,58	granulocyte colony-stimulating factor	G-CSF	25610(Tax:10116)	25610(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- on bacterial translocation in the splenectomized rat .
25795699	0	granulocyte_colony-stimulating_factor	171,208	GCSF	210,214	granulocyte colony-stimulating factor	GCSF	1440	1440	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	REpeated AutoLogous Infusions of STem cells In Cirrhosis -LRB- REALISTIC -RRB- : a multicentre , phase II , open-label , randomised controlled trial of repeated autologous infusions of granulocyte_colony-stimulating_factor -LRB- GCSF -RRB- mobilised CD133 + bone marrow stem cells in patients with cirrhosis .
9790917	0	granulocyte_colony-stimulating_factor	49,86	Hck	29,32	granulocyte colony-stimulating factor	Hck	1440	3055	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The Src-like tyrosine kinase Hck is activated by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and docks to the activated G-CSF_receptor .
21993883	0	granulocyte_colony-stimulating_factor	18,55	IL-17A	0,6	granulocyte colony-stimulating factor	IL-17A	1440	3605	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	IL-17A stimulates granulocyte_colony-stimulating_factor production via ERK1/2 but not p38 or JNK in human renal proximal tubular epithelial cells .
9773833	0	granulocyte_colony-stimulating_factor	37,74	IL-6	129,133	granulocyte colony-stimulating factor	IL-6	1440	3569	Gene	Gene	_|amod|START_ENTITY expression|nmod|_ expression|dep|beta beta|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
16498082	0	granulocyte_colony-stimulating_factor	51,88	IL-8	90,94	granulocyte colony-stimulating factor	PAR2	1440	2150	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Proteinase-activated_receptor2 agonists upregulate granulocyte_colony-stimulating_factor , IL-8 , and VCAM-1 expression in human bronchial fibroblasts .
9773833	0	granulocyte_colony-stimulating_factor	37,74	IL-8	135,139	granulocyte colony-stimulating factor	IL-8	1440	3576	Gene	Gene	_|amod|START_ENTITY expression|nmod|_ expression|dep|beta beta|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
8639772	0	granulocyte_colony-stimulating_factor	41,78	Interleukin-1_beta	0,18	granulocyte colony-stimulating factor	Interleukin-1 beta	1440	3553	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-1_beta induces production of granulocyte_colony-stimulating_factor in human hepatoma cells .
8796827	0	granulocyte_colony-stimulating_factor	61,98	Interleukin-1_beta	0,18	granulocyte colony-stimulating factor	Interleukin-1 beta	1440	3553	Gene	Gene	production|amod|START_ENTITY stimulate|dobj|production stimulate|nsubj|END_ENTITY	Interleukin-1_beta and tumor_necrosis_factor-alpha stimulate granulocyte_colony-stimulating_factor production by placental villous core mesenchymal cells .
9490696	0	granulocyte_colony-stimulating_factor	93,130	Interleukin-6	0,13	granulocyte colony-stimulating factor	Interleukin-6	1440	3569	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Interleukin-6 production by human neutrophils after Fc-receptor cross-linking or exposure to granulocyte_colony-stimulating_factor .
9452436	0	granulocyte_colony-stimulating_factor	64,101	Lyn	26,29	granulocyte colony-stimulating factor	Lyn	1440	421127(Tax:9031)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte_colony-stimulating_factor .
10914554	0	granulocyte_colony-stimulating_factor	75,112	SHP-1	55,60	granulocyte colony-stimulating factor	SHP-1	12985(Tax:10090)	15170(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The SH2 domain-containing protein tyrosine phosphatase SHP-1 is induced by granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and modulates signaling from the G-CSF_receptor .
8977235	0	granulocyte_colony-stimulating_factor	39,76	STAT5	107,112	granulocyte colony-stimulating factor	STAT5	1440	6776	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Multiple signaling pathways induced by granulocyte_colony-stimulating_factor involving activation of JAKs , STAT5 , and/or STAT3 are required for regulation of three distinct classes of immediate early genes .
11042034	0	granulocyte_colony-stimulating_factor	55,92	Stat5	27,32	granulocyte colony-stimulating factor	Stat5	1440	6776	Gene	Gene	activated|nmod|START_ENTITY activated|nsubj|Delineation Delineation|nmod|isoforms isoforms|amod|END_ENTITY	Delineation and mapping of Stat5 isoforms activated by granulocyte_colony-stimulating_factor in myeloid cells .
10643150	0	granulocyte_colony-stimulating_factor	62,99	Syk	49,52	granulocyte colony-stimulating factor	Syk	1440	6850	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Association of src-kinase Lyn and non-src-kinase Syk with the granulocyte_colony-stimulating_factor receptor -LRB- G-CSFR -RRB- is not abrogated in neutrophils from severe congenital_neutropenia patients with point mutations in the G-CSFR mRNA .
8753812	0	granulocyte_colony-stimulating_factor	14,51	THP-1	55,60	granulocyte colony-stimulating factor	THP-1	1440	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Production of granulocyte_colony-stimulating_factor by THP-1 cells in response to retinoic_acid and phorbol_ester is mediated through the autocrine production of interleukin-1 .
9367827	0	granulocyte_colony-stimulating_factor	82,119	THP-1	138,143	granulocyte colony-stimulating factor	THP-1	1440	2736	Gene	Gene	production|nmod|START_ENTITY stimulate|dobj|production stimulate|nmod|cells cells|compound|END_ENTITY	Dexamethasone and interleukin-1 potently synergize to stimulate the production of granulocyte_colony-stimulating_factor in differentiated THP-1 cells .
1375304	0	granulocyte_colony-stimulating_factor	56,93	TNF-alpha	18,27	granulocyte colony-stimulating factor	TNF-alpha	1440	7124	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Recombinant human TNF-alpha stimulates the secretion of granulocyte_colony-stimulating_factor in vivo .
2439155	0	granulocyte_colony-stimulating_factor	53,90	TNF_alpha	18,27	granulocyte colony-stimulating factor	TNF alpha	1440	7124	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Recombinant human TNF_alpha stimulates production of granulocyte_colony-stimulating_factor .
10089903	0	granulocyte_colony-stimulating_factor	13,50	erythropoietin	164,178	granulocyte colony-stimulating factor	erythropoietin	1440	2056	Gene	Gene	Expansion|nmod|START_ENTITY END_ENTITY|nsubj|Expansion	Expansion of granulocyte_colony-stimulating_factor / chemotherapy-mobilized CD34 + hematopoietic progenitors : role of granulocyte-macrophage_colony-stimulating_factor / erythropoietin hybrid protein -LRB- MEN11303 -RRB- and interleukin-15 .
7687889	0	granulocyte_colony-stimulating_factor	77,114	erythropoietin	135,149	granulocyte colony-stimulating factor	erythropoietin	1440	2056	Gene	Gene	using|dobj|START_ENTITY using|nmod|END_ENTITY	Treatment of the anemia of myelodysplastic syndromes using recombinant human granulocyte_colony-stimulating_factor in combination with erythropoietin .
9186538	0	granulocyte_colony-stimulating_factor	110,147	erythropoietin	75,89	granulocyte colony-stimulating factor	erythropoietin	1440	2056	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Treatment of the anemia of aplastic_anemia patients with recombinant human erythropoietin in combination with granulocyte_colony-stimulating_factor : a multicenter randomized controlled study .
12181756	0	granulocyte_colony-stimulating_factor	11,48	g-csf	50,55	granulocyte colony-stimulating factor	g-csf	25610(Tax:10116)	25610(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of granulocyte_colony-stimulating_factor -LRB- g-csf -RRB- on neutrophil phagocytosis during experimental_obstructive_jaundice .
15447861	0	granulocyte_colony-stimulating_factor	10,47	granulocyte-macrophage_colony-stimulating_factor	62,110	granulocyte colony-stimulating factor	granulocyte-macrophage colony-stimulating factor	1440	1437	Gene	Gene	combined|nsubj|START_ENTITY combined|nmod|END_ENTITY	-LSB- Low-dose granulocyte_colony-stimulating_factor combined with granulocyte-macrophage_colony-stimulating_factor for mobilizing peripheral CD34 + hematopoietic progenitor cells -RSB- .
1724550	0	granulocyte_colony-stimulating_factor	27,64	hG-CSF	66,72	granulocyte colony-stimulating factor	hG-CSF	1440	1440	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Protective effect of human granulocyte_colony-stimulating_factor -LRB- hG-CSF -RRB- on Cryptococcus and Aspergillus_infections in normal and immunosuppressed mice .
9672148	0	granulocyte_colony-stimulating_factor	14,51	interleukin-17	71,85	granulocyte colony-stimulating factor	interleukin-17	12985(Tax:10090)	16171(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of granulocyte_colony-stimulating_factor gene expression by interleukin-17 .
1280478	0	granulocyte_colony-stimulating_factor	46,83	interleukin-1_alpha	99,118	granulocyte colony-stimulating factor	interleukin-1 alpha	1440	3552	Gene	Gene	synthesize|dobj|START_ENTITY synthesize|nmod|END_ENTITY	Human arterial smooth_muscle_cells synthesize granulocyte_colony-stimulating_factor in response to interleukin-1_alpha and tumor_necrosis_factor-alpha .
7582261	0	granulocyte_colony-stimulating_factor	61,98	interleukin-6	19,32	granulocyte colony-stimulating factor	interleukin-6	1440	3569	Gene	Gene	level|amod|START_ENTITY Elevation|nmod|level Elevation|nmod|levels levels|amod|END_ENTITY	Elevation of serum interleukin-6 levels before peak of serum granulocyte_colony-stimulating_factor level in chemotherapy-induced myelosuppressive patients .
8555479	0	granulocyte_colony-stimulating_factor	15,52	interleukin-6	126,139	granulocyte colony-stimulating factor	interleukin-6	1440	3569	Gene	Gene	cells|nmod|START_ENTITY cells|acl|mobilized mobilized|ccomp|induce induce|dobj|secretion secretion|nmod|END_ENTITY	CD14 + cells in granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow_stroma .
7530467	0	granulocyte_colony-stimulating_factor	75,112	interleukin_3	191,204	granulocyte colony-stimulating factor	interleukin 3	12985(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- expression in bone marrow and fractionated marrow cell populations by interleukin_3 -LRB- IL-3 -RRB- : IL-3-mediated positive feedback mechanisms of granulopoiesis .
15969627	0	granulocyte_colony-stimulating_factor	46,83	matrix_metalloproteinase-9	121,147	granulocyte colony-stimulating factor	matrix metalloproteinase-9	12985(Tax:10090)	17395(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Hematopoietic progenitor cell mobilization by granulocyte_colony-stimulating_factor and erythropoietin in the absence of matrix_metalloproteinase-9 .
2444596	0	granulocyte_colony-stimulating_factor	88,125	myeloperoxidase	36,51	granulocyte colony-stimulating factor	myeloperoxidase	1440	4353	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte_colony-stimulating_factor .
1282572	0	granulocyte_colony-stimulating_factor	44,81	rG-CSF	83,89	granulocyte colony-stimulating factor	rG-CSF	1440	25610(Tax:10116)	Gene	Gene	significance|nmod|START_ENTITY significance|dep|END_ENTITY	-LSB- Clinical significance of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- in the chemotherapy of patients with malignant_lymphoma -RSB- .
1693062	0	granulocyte_colony-stimulating_factor	29,66	rG-CSF	68,74	granulocyte colony-stimulating factor	rG-CSF	1440	25610(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on chemotherapy-induced neutropenia in patients with lung_cancer -RSB- .
1704477	0	granulocyte_colony-stimulating_factor	39,76	rG-CSF	78,84	granulocyte colony-stimulating factor	rG-CSF	1440	25610(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Protective effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- against various microbial infections in neutropenic mice .
1705488	0	granulocyte_colony-stimulating_factor	22,59	rG-CSF	61,67	granulocyte colony-stimulating factor	rG-CSF	1440	25610(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of recombinant granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on chemotherapy-induced neutropenia in patients with urogenital_cancer .
1717812	0	granulocyte_colony-stimulating_factor	52,89	rG-CSF	91,97	granulocyte colony-stimulating factor	rG-CSF	1440	25610(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY Mechanism|nmod|effect Mechanism|dep|END_ENTITY	Mechanism of protective effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on Pseudomonas_infection .
2450817	0	granulocyte_colony-stimulating_factor	45,82	rG-CSF	84,90	granulocyte colony-stimulating factor	rG-CSF	1440	25610(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Proliferative effects of a recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on highly enriched hematopoietic progenitor cells .
12130497	0	granulocyte_colony-stimulating_factor	128,165	stem_cell_factor	186,202	granulocyte colony-stimulating factor	stem cell factor	1440	4254	Gene	Gene	granulocyte_colony-stimulating_factor|nmod|START_ENTITY mobilized|nmod|granulocyte_colony-stimulating_factor mobilized|nmod|END_ENTITY	Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte_colony-stimulating_factor alone versus granulocyte_colony-stimulating_factor in combination with stem_cell_factor .
12130497	0	granulocyte_colony-stimulating_factor	77,114	stem_cell_factor	186,202	granulocyte colony-stimulating factor	stem cell factor	1440	4254	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nmod|END_ENTITY	Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte_colony-stimulating_factor alone versus granulocyte_colony-stimulating_factor in combination with stem_cell_factor .
12634728	0	granulocyte_colony-stimulating_factor	166,203	stem_cell_factor	83,99	granulocyte colony-stimulating factor	stem cell factor	1440	4254	Gene	Gene	filgrastim|appos|START_ENTITY failed|nmod|filgrastim patients|acl:relcl|failed ancestim|nmod|patients ancestim|appos|END_ENTITY	Successful mobilization of peripheral blood stem cells after addition of ancestim -LRB- stem_cell_factor -RRB- in patients who had failed a prior mobilization with filgrastim -LRB- granulocyte_colony-stimulating_factor -RRB- alone or with chemotherapy plus filgrastim .
16787870	0	granulocyte_colony-stimulating_factor	71,108	stem_cell_factor	40,56	granulocyte colony-stimulating factor	stem cell factor	1440	4254	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|response response|nmod|administration administration|nmod|END_ENTITY	Stable response after administration of stem_cell_factor combined with granulocyte_colony-stimulating_factor in aplastic_anemia .
1714329	0	granulocyte_colony-stimulating_factor	145,182	stem_cell_factor	44,60	granulocyte colony-stimulating factor	stem cell factor	1440	17311(Tax:10090)	Gene	Gene	administered|nmod|START_ENTITY administered|nsubj|effects effects|nmod|hematopoiesis hematopoiesis|nmod|END_ENTITY	The effects on hematopoiesis of recombinant stem_cell_factor -LRB- ligand for c-kit -RRB- administered in vivo to mice either alone or in combination with granulocyte_colony-stimulating_factor .
7519076	0	granulocyte_colony-stimulating_factor	113,150	stem_cell_factor	91,107	granulocyte colony-stimulating factor	stem cell factor	1440	17311(Tax:10090)	Gene	Gene	Mobilization|nmod|START_ENTITY Mobilization|nmod|cells cells|nmod|mice mice|nmod|combination combination|nmod|END_ENTITY	Mobilization of long-term hematopoietic reconstituting cells in mice by the combination of stem_cell_factor plus granulocyte_colony-stimulating_factor .
7691233	0	granulocyte_colony-stimulating_factor	67,104	stem_cell_factor	16,32	granulocyte colony-stimulating factor	stem cell factor	1440	60427(Tax:10116)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Recombinant rat stem_cell_factor synergizes with recombinant human granulocyte_colony-stimulating_factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential .
10216073	0	granulocyte_colony-stimulating_factor	53,90	thrombopoietin	18,32	granulocyte colony-stimulating factor	thrombopoietin	1440	7066	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Recombinant human thrombopoietin in combination with granulocyte_colony-stimulating_factor enhances mobilization of peripheral blood progenitor cells , increases peripheral blood platelet concentration , and accelerates hematopoietic recovery following high-dose chemotherapy .
1701357	0	granulocyte_colony-stimulating_factor	57,94	transferrin_receptor	17,37	granulocyte colony-stimulating factor	transferrin receptor	1440	7037	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of transferrin_receptor gene expression by granulocyte_colony-stimulating_factor in human myeloid_leukemia cells .
7691787	0	granulocyte_colony-stimulating_factor	107,144	tumor_necrosis_factor	47,68	granulocyte colony-stimulating factor	tumor necrosis factor	1440	7124	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Enhanced antitumor effect of recombinant human tumor_necrosis_factor in combination with recombinant human granulocyte_colony-stimulating_factor in BALB/c mice .
7541223	0	granulocyte_colony-stimulating_factor	25,62	tumor_necrosis_factor-alpha	72,99	granulocyte colony-stimulating factor	tumor necrosis factor-alpha	1440	7124	Gene	Gene	activated|nmod|START_ENTITY Neutrophils|acl|activated suppress|nsubj|Neutrophils suppress|dobj|release release|amod|END_ENTITY	Neutrophils activated by granulocyte_colony-stimulating_factor suppress tumor_necrosis_factor-alpha release from monocytes stimulated by endotoxin .
8551973	0	granulocyte_colony-stimulating_factor	120,157	tumor_necrosis_factor-alpha	14,41	granulocyte colony-stimulating factor	tumor necrosis factor-alpha	12985(Tax:10090)	21926(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of tumor_necrosis_factor-alpha in granulocytopenic mice with pulmonary_candidiasis and its modification with granulocyte_colony-stimulating_factor .
9773833	0	granulocyte_colony-stimulating_factor	37,74	tumor_necrosis_factor-alpha	76,103	granulocyte colony-stimulating factor	tumor necrosis factor-alpha	1440	7124	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
17127322	0	granulocyte_colony-stimulating_factor_receptor	16,62	G-CSF-R	64,71	granulocyte colony-stimulating factor receptor	G-CSF-R	1441	1441	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the granulocyte_colony-stimulating_factor_receptor -LRB- G-CSF-R -RRB- in disease .
7531515	0	granulocyte_colony-stimulating_factor_receptor	24,70	G-CSF-R	72,79	granulocyte colony-stimulating factor receptor	G-CSF-R	1441	1441	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A point mutation in the granulocyte_colony-stimulating_factor_receptor -LRB- G-CSF-R -RRB- gene in a case of acute_myeloid_leukemia results in the overexpression of a novel G-CSF-R isoform .
9490675	0	granulocyte_colony-stimulating_factor_receptor	89,135	Shc	42,45	granulocyte colony-stimulating factor receptor	Shc	1441	6464	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Proliferation signaling and activation of Shc , p21Ras , and Myc via tyrosine 764 of human granulocyte_colony-stimulating_factor_receptor .
7678333	0	granulocyte_colony-stimulating_factor_receptor	92,138	growth_hormone_receptor	32,55	granulocyte colony-stimulating factor receptor	growth hormone receptor	12986(Tax:10090)	14600(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Signal transduction mediated by growth_hormone_receptor and its chimeric molecules with the granulocyte_colony-stimulating_factor_receptor .
18335482	0	granulocyte_colony_stimulating_factor	15,52	G-CSF	54,59	granulocyte colony stimulating factor	G-CSF	1440	1440	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Pilot study of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood stem cells in amyotrophic_lateral_sclerosis -LRB- ALS -RRB- .
19322972	0	granulocyte_colony_stimulating_factor	8,45	G-CSF	47,52	granulocyte colony stimulating factor	G-CSF	1440	1440	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in chemotherapy induced neutropenia .
7531660	0	granulocyte_colony_stimulating_factor	11,48	G-CSF	50,55	granulocyte colony stimulating factor	G-CSF	1440	1440	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- on peripheral blood leukocytes and lymphocytes in patients with chemotherapy-induced leukopenia -RSB- .
9066582	0	granulocyte_colony_stimulating_factor	19,56	G-CSF	58,63	granulocyte colony stimulating factor	G-CSF	1440	1440	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression of granulocyte_colony_stimulating_factor -LRB- G-CSF -RRB- in non-small cell lung_cancer .
1721105	0	granulocyte_colony_stimulating_factor	27,64	hG-CSF	66,72	granulocyte colony stimulating factor	hG-CSF	1440	1440	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	Protective effect of human granulocyte_colony_stimulating_factor -LRB- hG-CSF -RRB- on Candida_infections in normal and immunosuppressed mice .
22714276	0	granulocyte_colony_stimulating_factor	20,57	hG-CSF	59,65	granulocyte colony stimulating factor	hG-CSF	1440	1440	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of human granulocyte_colony_stimulating_factor -LRB- hG-CSF -RRB- in colon_adenocarcinoma cell line -LRB- Caco-2 -RRB- .
26549378	0	granulocyte_colony_stimulating_factor	49,86	hGMCSF	88,94	granulocyte colony stimulating factor	hGMCSF	1440	1437	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of recombinant human granulocyte_colony_stimulating_factor -LRB- hGMCSF -RRB- immobilized onto silica nanoparticles .
8278382	0	granulocyte_inhibitory_protein	2,32	interleukin_6	96,109	granulocyte inhibitory protein	interleukin 6	2695	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	A granulocyte_inhibitory_protein overexpressed in chronic renal_disease regulates expression of interleukin_6 and interleukin_8 .
10566662	0	granulocyte_macrophage-colony-stimulating_factor	61,109	transforming_growth_factor-beta1	14,46	granulocyte macrophage-colony-stimulating factor	transforming growth factor-beta1	1437	7040	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of transforming_growth_factor-beta1 expression by granulocyte_macrophage-colony-stimulating_factor in leiomyoma and myometrial smooth muscle cells .
12206872	0	granulocyte_macrophage-colony_stimulating_factor	26,74	GM-CSF	76,82	granulocyte macrophage-colony stimulating factor	GM-CSF	1437	1437	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of endometrial granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- in the ewe .
16414253	0	granulocyte_macrophage-colony_stimulating_factor	10,58	GM-CSF	60,66	granulocyte macrophage-colony stimulating factor	GM-CSF	1437	1437	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- on 5-FU-induced ulcerative_mucositis in hamster buccal pouches .
11956032	0	granulocyte_macrophage-colony_stimulating_factor	90,138	IL-1beta	33,41	granulocyte macrophage-colony stimulating factor	IL-1beta	1437	3553	Gene	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	The effect of interleukin-1beta -LRB- IL-1beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on granulocyte_macrophage-colony_stimulating_factor -LRB- GM-CSF -RRB- production by neuronal precursor cells .
11330966	0	granulocyte_macrophage-colony_stimulating_factor	29,77	TGF-beta	103,111	granulocyte macrophage-colony stimulating factor	TGF-beta	1437	7040	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression and action of granulocyte_macrophage-colony_stimulating_factor and its interaction with TGF-beta in endometrial_carcinoma .
9175761	0	granulocyte_macrophage-colony_stimulating_factor	47,95	c-Jun_N-terminal_kinase	14,37	granulocyte macrophage-colony stimulating factor	c-Jun N-terminal kinase	1437	5599	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of c-Jun_N-terminal_kinase by human granulocyte_macrophage-colony_stimulating_factor in BA/F3 cells .
11437276	0	granulocyte_macrophage-colony_stimulating_factor	32,80	hGM-CSF	82,89	granulocyte macrophage-colony stimulating factor	hGM-CSF	1437	1437	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of recombinant human granulocyte_macrophage-colony_stimulating_factor -LRB- hGM-CSF -RRB- in mouse urine .
1385708	0	granulocyte_macrophage_colony-stimulating_factor	47,95	alpha_1-antitrypsin	14,33	granulocyte macrophage colony-stimulating factor	alpha 1-antitrypsin	1437	5265	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|synthesis synthesis|amod|END_ENTITY	Regulation of alpha_1-antitrypsin synthesis by granulocyte_macrophage_colony-stimulating_factor in the U937 promonocytic cell line .
12740386	0	granulocyte_macrophage_colony-stimulating_factor	50,98	p70S6_kinase	23,35	granulocyte macrophage colony-stimulating factor	p70S6 kinase	1437	6198	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Mechanism of ribosomal p70S6_kinase activation by granulocyte_macrophage_colony-stimulating_factor in neutrophils : cooperation of a MEK-related , THR421/SER424 kinase and a rapamycin-sensitive , m-TOR-related THR389 kinase .
10969805	0	granulocyte_macrophage_colony-stimulating_factor	45,93	retinoic_acid_receptor-alpha	13,41	granulocyte macrophage colony-stimulating factor	retinoic acid receptor-alpha	1437	5914	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of retinoic_acid_receptor-alpha by granulocyte_macrophage_colony-stimulating_factor in human myeloid_leukemia cell lines .
25737095	0	granulocyte_macrophage_colony-stimulating_factor	24,72	transferrin	73,84	granulocyte macrophage colony-stimulating factor	transferrin	1437	7018	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Engineering superactive granulocyte_macrophage_colony-stimulating_factor transferrin fusion proteins as orally-delivered candidate agents for treating neurodegenerative_disease .
18490721	0	granulysin	19,29	CD4	46,49	granulysin	CD4	10578	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Late expression of granulysin by microbicidal CD4 + T cells requires PI3K - and STAT5-dependent expression of IL-2Rbeta that is defective in HIV-infected patients .
19687290	0	granulysin	13,23	CD8	27,30	granulysin	CD8	10578	925	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Induction of granulysin in CD8 + T cells by IL-21 and IL-15 is suppressed by human_immunodeficiency_virus-1 .
19687290	0	granulysin	13,23	IL-21	43,48	granulysin	IL-21	10578	59067	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Induction of granulysin in CD8 + T cells by IL-21 and IL-15 is suppressed by human_immunodeficiency_virus-1 .
11807624	0	granulysin	110,120	granulysin	27,37	granulysin	granulysin	10578	10578	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer .
11807624	0	granulysin	27,37	granulysin	110,120	granulysin	granulysin	10578	10578	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer .
10449281	0	granzyme_A	34,44	CD8	74,77	granzyme A	CD8	3001	925	Gene	Gene	co-expressed|nmod|START_ENTITY co-expressed|nmod|granules granules|nmod|present present|compound|END_ENTITY	Perforin is not co-expressed with granzyme_A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic_HIV_infection .
19646207	0	granzyme_A	41,51	CD8	15,18	granzyme A	CD8	3001	925	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing associated|nsubjpass|cells T|ccomp|associated T|nsubj|Recruitment Recruitment|nmod|END_ENTITY	Recruitment of CD8 -LRB- + -RRB- T cells expressing granzyme_A is associated with lesion progression in human cutaneous_leishmaniasis .
26519105	0	granzyme_A	97,107	CD8	137,140	granzyme A	CD8	3001	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme_A expression by virus-specific CD8 -LRB- + -RRB- T cells .
8419181	0	granzyme_A	28,38	MTSP-1	40,46	granzyme A	MTSP-1	14938(Tax:10090)	19143(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Charge-dependent binding of granzyme_A -LRB- MTSP-1 -RRB- to basement membranes .
24505135	0	granzyme_A	56,66	Serpinb6b	18,27	granzyme A	Serpinb6b	14938(Tax:10090)	20708(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	Identification of Serpinb6b as a species-specific mouse granzyme_A inhibitor suggests functional divergence between human and mouse granzyme_A .
24999042	0	granzyme_B	36,46	CCR5	61,65	granzyme B	CCR5	3002	1234	Gene	Gene	production|amod|START_ENTITY production|nmod|T T|compound|END_ENTITY	HIV replication in conjunction with granzyme_B production by CCR5 + memory CD4 T cells : Implications for bystander cell and tissue pathologies .
19616200	0	granzyme_B	61,71	CD4	11,14	granzyme B	CD4	3002	920	Gene	Gene	expressed|nsubj|START_ENTITY expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
24999042	0	granzyme_B	36,46	CD4	74,77	granzyme B	CD4	3002	920	Gene	Gene	production|amod|START_ENTITY production|nmod|T T|compound|END_ENTITY	HIV replication in conjunction with granzyme_B production by CCR5 + memory CD4 T cells : Implications for bystander cell and tissue pathologies .
15356127	0	granzyme_B	15,25	CD8	67,70	granzyme B	CD8	3002	925	Gene	Gene	serine|amod|START_ENTITY role|nmod|serine protease|nsubj|role protease|dobj|inhibitor inhibitor|nmod|homeostasis homeostasis|compound|END_ENTITY	A role for the granzyme_B inhibitor serine protease inhibitor 6 in CD8 + memory cell homeostasis .
15875183	0	granzyme_B	20,30	CD8	42,45	granzyme B	CD8	3002	925	Gene	Gene	T|compound|START_ENTITY T|compound|END_ENTITY	Decreased number of granzyme_B + activated CD8 + cytotoxic T lymphocytes in the inflammatory background of HIV-associated_Hodgkin 's _ lymphoma .
16547231	0	granzyme_B	107,117	CD8	65,68	granzyme B	CD8	3002	925	Gene	Gene	role|nmod|START_ENTITY death|dep|role death|dep|lymphocytes lymphocytes|amod|concurrent concurrent|nmod|stimulation stimulation|nmod|T T|compound|END_ENTITY	Apoptotic death concurrent with CD3 stimulation in primary human CD8 + T lymphocytes : a role for endogenous granzyme_B .
17125145	0	granzyme_B	14,24	CD8	48,51	granzyme B	CD8	3002	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Bcl6 controls granzyme_B expression in effector CD8 + T cells .
19616200	0	granzyme_B	61,71	CD8	15,18	granzyme B	CD8	3002	925	Gene	Gene	expressed|nsubj|START_ENTITY expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
22430249	0	granzyme_B	57,67	CD8	36,39	granzyme B	CD8	3002	925	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|induction induction|nmod|cells cells|amod|IL-21 IL-21|nmod|T T|compound|END_ENTITY	IL-27 induction of IL-21 from human CD8 + T cells induces granzyme_B in an autocrine manner .
23421932	0	granzyme_B	43,53	CD8	20,23	granzyme B	CD8	3002	925	Gene	Gene	START_ENTITY|nsubj|role role|nmod|+ +|compound|END_ENTITY	A possible role for CD8 + and non-CD8 + cell granzyme_B in early small airway wall remodelling in centrilobular_emphysema .
9640249	0	granzyme_B	9,19	CD8	4,7	granzyme B	CD8	3002	925	Gene	Gene	START_ENTITY|nmod:npmod|+ +|nummod|END_ENTITY	The CD8 + granzyme_B + T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells .
25159843	0	granzyme_B	67,77	Cytohesin-associated_scaffolding_protein	0,40	granzyme B	Cytohesin-associated scaffolding protein	3002	9595	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Cytohesin-associated_scaffolding_protein -LRB- CASP -RRB- is a substrate for granzyme_B and ubiquitination .
25139496	0	granzyme_B	36,46	Fas_ligand	24,34	granzyme B	Fas ligand	3002	356	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of soluble Fas_ligand , granzyme_B and cytochrome_c during adjuvant chemotherapy of breast_cancer .
17620340	0	granzyme_B	35,45	Hip	0,3	granzyme B	Hip	3002	6767	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Hip is a pro-survival substrate of granzyme_B .
8805307	0	granzyme_B	25,35	ICE-LAP3	69,77	granzyme B	ICE-LAP3	3002	840	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Cytotoxic T-cell-derived granzyme_B activates the apoptotic protease ICE-LAP3 .
8663294	0	granzyme_B	101,111	ICE-LAP6	0,8	granzyme B	ICE-LAP6	3002	842	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	ICE-LAP6 , a novel member of the ICE/Ced -3 gene family , is activated by the cytotoxic T cell protease granzyme_B .
18405889	0	granzyme_B	54,64	Interleukin-10	0,14	granzyme B	Interleukin-10	3002	3586	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Interleukin-10 containing normal human serum inhibits granzyme_B release but not perforin release from alloreactive and EBV-specific T cell clones .
11485349	0	granzyme_B	4,14	PI-9	26,30	granzyme B	PI-9	3002	5272	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The granzyme_B inhibitor , PI-9 , is present in endothelial and mesothelial cells , suggesting that it protects bystander cells during immune responses .
11562487	0	granzyme_B	16,26	PI-9	100,104	granzyme B	PI-9	3002	5272	Gene	Gene	Blockade|nmod|START_ENTITY Blockade|dep|perforin perforin|nmod|overexpression overexpression|nmod|END_ENTITY	Blockade of the granzyme_B / perforin pathway through overexpression of the serine protease inhibitor PI-9 / SPI-6 constitutes a mechanism for immune escape by tumors .
15791691	0	granzyme_B	72,82	PI-9	147,151	granzyme B	PI-9	3002	5272	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|modulation modulation|nmod|END_ENTITY	Interaction of the nuclear localizing cytolytic granule serine protease granzyme_B with importin alpha or beta : modulation by the serpin inhibitor PI-9 .
16310039	0	granzyme_B	4,14	PI-9	26,30	granzyme B	PI-9	3002	5272	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The granzyme_B inhibitor , PI-9 , is differentially expressed during placental development and up-regulated in hydatidiform moles .
16487253	0	granzyme_B	18,28	PI-9	63,67	granzyme B	PI-9	3002	5272	Gene	Gene	inhibitor|amod|START_ENTITY Modulation|nmod|inhibitor proteinase|nsubj|Modulation proteinase|dobj|inhibitor inhibitor|appos|END_ENTITY	Modulation of the granzyme_B inhibitor proteinase inhibitor 9 -LRB- PI-9 -RRB- by activation of lymphocytes and monocytes in vitro and by Epstein-Barr_virus and bacterial_infection .
10400732	0	granzyme_B	42,52	Serp2	13,18	granzyme B	Serp2	3002	387923	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Myxoma_virus Serp2 is a weak inhibitor of granzyme_B and interleukin-1beta-converting enzyme in vitro and unlike CrmA can not block apoptosis in cowpox_virus-infected cells .
8836920	0	granzyme_B	86,96	interleukin-10	56,70	granzyme B	interleukin-10	14939(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Anti-CD3-activated killer T cells : interferon-gamma and interleukin-10 cross-regulate granzyme_B expression and the induction of major histocompatibility complex-unrestricted cytotoxicity .
16032371	0	granzyme_B	50,60	interleukins_2_and_12	11,32	granzyme B	interleukins 2 and 12	3002	3558	Gene	Gene	levels|nmod|START_ENTITY Effects|nmod|levels Effects|nmod|END_ENTITY	Effects of interleukins_2_and_12 on the levels of granzyme_B and perforin and their mRNAs in tributyltin-exposed human natural killer cells .
11278311	0	granzyme_B	39,49	proteinase_inhibitor_9	116,138	granzyme B	proteinase inhibitor 9	3002	5272	Gene	Gene	inhibitors|compound|START_ENTITY residue|nmod|inhibitors Importance|nmod|residue revealed|nsubj|Importance revealed|advcl|scanning scanning|dobj|mutagenesis mutagenesis|nmod|loop loop|amod|END_ENTITY	Importance of the P4 ' residue in human granzyme_B inhibitors and substrates revealed by scanning mutagenesis of the proteinase_inhibitor_9 reactive center loop .
12517944	0	granzyme_B	18,28	proteinase_inhibitor_9	40,62	granzyme B	proteinase inhibitor 9	3002	5272	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	The intracellular granzyme_B inhibitor , proteinase_inhibitor_9 , is up-regulated during accessory cell maturation and effector cell degranulation , and its overexpression enhances CTL potency .
16306080	0	granzyme_B	26,36	proteinase_inhibitor_9	48,70	granzyme B	proteinase inhibitor 9	3002	5272	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Estrogen induction of the granzyme_B inhibitor , proteinase_inhibitor_9 , protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells .
12388539	1	granzyme_B	93,103	serglycin	109,118	granzyme B	serglycin	3002	5552	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the macromolecular complex of granzyme_B with serglycin .
15843372	0	granzyme_B	41,51	vitronectin	68,79	granzyme B	vitronectin	3002	7448	Gene	Gene	START_ENTITY|nmod|cleavage cleavage|nmod|END_ENTITY	Extracellular matrix remodeling by human granzyme_B via cleavage of vitronectin , fibronectin , and laminin .
20876349	0	granzyme_K	39,49	Valosin-containing_protein	0,26	granzyme K	Valosin-containing protein	3003	7415	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Valosin-containing_protein cleavage by granzyme_K accelerates an endoplasmic reticulum stress leading to caspase-independent cytotoxicity of target_tumor cells .
19103589	0	granzyme_M	75,85	Nucleophosmin	0,13	granzyme M	Nucleophosmin	3004	4869	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme_M during natural killer cell-mediated killing .
18523284	0	granzyme_M	17,27	alpha-tubulin	36,49	granzyme M	alpha-tubulin	3004	10376	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	NK cell protease granzyme_M targets alpha-tubulin and disorganizes the microtubule network .
18339716	0	grb14	68,73	growth_factor_receptor-bound_protein_14	27,66	grb14	growth factor receptor-bound protein 14	50915(Tax:10090)	50915(Tax:10090)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Dual effect of the adapter growth_factor_receptor-bound_protein_14 -LRB- grb14 -RRB- on insulin action in primary hepatocytes .
17522159	0	gremlin_1	30,39	BMP4	13,17	gremlin 1	BMP4	23892(Tax:10090)	12159(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Reduction of BMP4 activity by gremlin_1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis .
19577778	0	gremlin_1	14,23	GREM1	25,30	gremlin 1	GREM1	26585	26585	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of gremlin_1 -LRB- GREM1 -RRB- as a candidate susceptibility gene for albuminuria-related traits in Mexican Americans with type_2_diabetes_mellitus .
7688736	0	gro-beta	38,46	NF-kappa_B	51,61	gro-beta	NF-kappa B	2920	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Interleukin-1-inducible expression of gro-beta via NF-kappa_B activation is dependent upon tyrosine kinase signaling .
7902576	0	groES	61,66	chaperonin_10	42,55	groES	chaperonin 10	13876916	854185(Tax:4932)	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Identification and functional analysis of chaperonin_10 , the groES homolog from yeast mitochondria .
9705972	0	gross_cystic_disease_fluid_protein-15	14,51	Prolactin-inducible_protein	52,79	gross cystic disease fluid protein-15	Prolactin-inducible protein	5304	5304	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of gross_cystic_disease_fluid_protein-15 / Prolactin-inducible_protein in rat salivary glands .
10471788	0	groucho	38,45	R-esp1	0,6	groucho	R-esp1	43162(Tax:7227)	29466(Tax:10116)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	R-esp1 , a rat homologue of drosophila groucho , is differentially expressed after optic nerve crush and mediates NGF-induced survival of PC12 cells .
15527765	0	group_IIA_phospholipase_A2	52,78	Glycogen_synthase_kinase-3beta	0,30	group IIA phospholipase A2	Glycogen synthase kinase-3beta	5320	2932	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta negatively regulates group_IIA_phospholipase_A2 expression in human aortic smooth muscle and HepG2 hepatoma cells .
12631465	0	growth-associated_phosphoprotein	40,72	GAP-43	74,80	growth-associated phosphoprotein	GAP-43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Influence of peripheral inflammation on growth-associated_phosphoprotein -LRB- GAP-43 -RRB- expression in dorsal root ganglia and on nerve recovery after crush injury .
1333338	0	growth-associated_protein	27,52	GAP-43	54,60	growth-associated protein	GAP-43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Differential expression of growth-associated_protein -LRB- GAP-43 -RRB- mRNA in rat primary sensory neurons after peripheral_nerve_lesion : a non-radioactive in situ hybridisation study .
7907951	0	growth-associated_protein	37,62	GAP-43	64,70	growth-associated protein	GAP-43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of a growth-associated_protein -LRB- GAP-43 -RRB- in rat adrenal gland .
9355109	0	growth-associated_protein	30,55	GAP-43	56,62	growth-associated protein	GAP-43	2596	2596	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Gonadal steroid regulation of growth-associated_protein GAP-43 mRNA expression in axotomized hamster facial motor neurons .
8859903	0	growth-associated_protein_43	40,68	GAP-43	70,76	growth-associated protein 43	GAP-43	493873(Tax:9685)	493873(Tax:9685)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Long-term effects of retinal lesions on growth-associated_protein_43 -LRB- GAP-43 -RRB- expression in the visual system of adult cats .
1661809	0	growth-associated_protein_43_kDa	44,76	GAP-43	78,84	growth-associated protein 43 kDa	GAP-43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Estrogenic regulation and sex dimorphism of growth-associated_protein_43_kDa -LRB- GAP-43 -RRB- messenger RNA in the rat .
2552034	0	growth-associated_protein_B-50	14,44	GAP43	46,51	growth-associated protein B-50	GAP43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of growth-associated_protein_B-50 -LRB- GAP43 -RRB- in dorsal root ganglia and sciatic nerve during regenerative sprouting .
15169878	0	growth-differentiation_factor_11	18,50	histone_deacetylase	63,82	growth-differentiation factor 11	histone deacetylase	10220	9734	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Activation of the growth-differentiation_factor_11 gene by the histone_deacetylase -LRB- HDAC -RRB- inhibitor trichostatin_A and repression by HDAC3 .
24323236	0	growth-hormone	38,52	Insulin-like_growth_factor-I	0,28	growth-hormone	Insulin-like growth factor-I	2688	3479	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Insulin-like_growth_factor-I and fast growth-hormone levels in mild and moderately malnourished children .
12846737	0	growth-hormone-receptor	14,37	growth_hormone	57,71	growth-hormone-receptor	growth hormone	2690	2688	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of growth-hormone-receptor gene expression by growth_hormone and pegvisomant in human mesangial cells .
3930577	0	growth-hormone-releasing_factor	20,51	GRF	53,56	growth-hormone-releasing factor	GRF	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	The distribution of growth-hormone-releasing_factor -LRB- GRF -RRB- immunoreactivity in the central nervous system of the rat : an immunohistochemical study using antisera directed against rat hypothalamic GRF .
26004619	0	growth_and_differentiation_factor_15	15,51	GDF15	8,13	growth and differentiation factor 15	GDF15	9518	9518	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of GDF15 -LRB- growth_and_differentiation_factor_15 -RRB- in pulmonary_oxygen_toxicity .
22963770	0	growth_and_differentiation_factor_3	20,55	NANOG	75,80	growth and differentiation factor 3	NANOG	9573	79923	Gene	Gene	expression|amod|START_ENTITY expression|acl|END_ENTITY	Regulation of human growth_and_differentiation_factor_3 gene expression by NANOG in human embryonic_carcinoma NCCIT cells .
19369636	0	growth_arrest-specific_6	16,40	GAS6	42,46	growth arrest-specific 6	GAS6	2621	2621	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Plasma level of growth_arrest-specific_6 -LRB- GAS6 -RRB- protein and genetic variations in the GAS6 gene in patients with acute_coronary_syndrome .
21959217	0	growth_arrest-specific_6	4,28	Gas6	30,34	growth arrest-specific 6	Gas6	2621	2621	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	The growth_arrest-specific_6 -LRB- Gas6 -RRB- gene polymorphism c. 834 +7 G > A is associated with type 2 diabetes .
25915719	0	growth_arrest-specific_6	24,48	Gas6	50,54	growth arrest-specific 6	Gas6	2621	2621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the growth_arrest-specific_6 -LRB- Gas6 -RRB- gene polymorphism c. 834 ___ + ___ 7G > A and preeclampsia .
25915719	0	growth_arrest-specific_6	24,48	Gas6	50,54	growth arrest-specific 6	Gas6	2621	2621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the growth_arrest-specific_6 -LRB- Gas6 -RRB- gene polymorphism c. 834 ___ + ___ 7G > A and preeclampsia .
1630459	0	growth_arrest-specific_gene	31,58	gas5	60,64	growth arrest-specific gene	gas5	14455(Tax:10090)	14455(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation and expression of a growth_arrest-specific_gene -LRB- gas5 -RRB- during growth , differentiation , and development .
10400186	0	growth_arrest-specific_gene_6	18,47	GAS6	49,53	growth arrest-specific gene 6	GAS6	2621	2621	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the growth_arrest-specific_gene_6 -LRB- GAS6 -RRB- in leukemia and lymphoma cell lines .
24512357	0	growth_arrest-specific_protein_6	22,54	Gas6	56,60	growth arrest-specific protein 6	Gas6	2621	2621	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Association of plasma growth_arrest-specific_protein_6 -LRB- Gas6 -RRB- concentrations with albuminuria in patients with type 2 diabetes .
26788441	0	growth_arrest-specific_protein_6	12,44	erythropoietin	72,86	growth arrest-specific protein 6	erythropoietin	2621	2056	Gene	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|resistance resistance|compound|END_ENTITY	Circulating growth_arrest-specific_protein_6 levels are associated with erythropoietin resistance in hemodialysis patients .
18360812	0	growth_arrest_specific_6	63,87	GAS6	89,93	growth arrest specific 6	GAS6	2621	2621	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Development and validation of an ELISA method for detection of growth_arrest_specific_6 -LRB- GAS6 -RRB- protein in human plasma .
8220312	0	growth_arrest_specific_gene	35,62	gas-1	64,69	growth arrest specific gene	gas-1	683470(Tax:10116)	683470(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Estrogen-regulated expression of a growth_arrest_specific_gene -LRB- gas-1 -RRB- in rat uterus .
11411309	0	growth_arrest_specific_gene	4,31	gas6	33,37	growth arrest specific gene	gas6	101822418	101822418	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The growth_arrest_specific_gene -LRB- gas6 -RRB- protein is expressed in abnormal embryos sired by male golden_hamsters with accessory sex glands removed .
15680482	0	growth_arrest_specific_homeobox	26,57	Gax	59,62	growth arrest specific homeobox	Gax	4223	4223	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II suppresses growth_arrest_specific_homeobox -LRB- Gax -RRB- expression via redox-sensitive mitogen-activated protein kinase -LRB- MAPK -RRB- .
11374816	0	growth_associated_protein	16,41	GAP-43	43,49	growth associated protein	GAP-43	100623423	100623423	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of growth_associated_protein -LRB- GAP-43 -RRB- immunoreactivity in nerve fibers supplying the pig pineal gland .
25806072	0	growth_associated_protein-43	27,55	Erythropoietin	0,14	growth associated protein-43	Erythropoietin	29423(Tax:10116)	24335(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Erythropoietin upregulates growth_associated_protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush .
23731455	0	growth_differentiation_factor-15	19,51	GDF-15	53,59	growth differentiation factor-15	GDF-15	9518	9518	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum hepcidin and growth_differentiation_factor-15 -LRB- GDF-15 -RRB- levels in polycythemia vera and essential_thrombocythemia .
17453295	0	growth_differentiation_factor-9	12,43	BMP-15	75,81	growth differentiation factor-9	BMP-15	2661	9210	Gene	Gene	role|nmod|START_ENTITY role|amod|END_ENTITY	The role of growth_differentiation_factor-9 -LRB- GDF-9 -RRB- and its analog , GDF-9b / BMP-15 , in human breast_cancer .
12135884	0	growth_differentiation_factor-9	62,93	Bone_morphogenetic_protein_receptor_type_II	0,43	growth differentiation factor-9	Bone morphogenetic protein receptor type II	2661	659	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Bone_morphogenetic_protein_receptor_type_II is a receptor for growth_differentiation_factor-9 .
10612437	0	growth_differentiation_factor-9	16,47	GDF-9	49,54	growth differentiation factor-9	GDF-9	59304(Tax:10116)	59304(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of growth_differentiation_factor-9 -LRB- GDF-9 -RRB- mRNA and protein in rat ovaries and cDNA cloning of rat GDF-9 and its novel homolog GDF-9B .
11090434	0	growth_differentiation_factor-9	26,57	KIT_ligand	83,93	growth differentiation factor-9	KIT ligand	14566(Tax:10090)	17311(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Comparison of recombinant growth_differentiation_factor-9 and oocyte regulation of KIT_ligand messenger ribonucleic acid expression in mouse ovarian follicles .
26733738	0	growth_differentiation_factor_11	14,46	GDF11	48,53	growth differentiation factor 11	GDF11	606826(Tax:9615)	606826(Tax:9615)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Evaluation of growth_differentiation_factor_11 -LRB- GDF11 -RRB- levels in dogs with chronic mitral_valve_insufficiency .
23423687	0	growth_differentiation_factor_5	16,47	GDF5	49,53	growth differentiation factor 5	GDF5	8200	8200	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rs143383 in the growth_differentiation_factor_5 -LRB- GDF5 -RRB- gene significantly associated with osteoarthritis -LRB- OA -RRB- - a comprehensive meta-analysis .
21936909	0	growth_differentiation_factor_5	36,67	GDF_5	69,74	growth differentiation factor 5	GDF 5	8200	8200	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A genetic association study between growth_differentiation_factor_5 -LRB- GDF_5 -RRB- polymorphism and knee osteoarthritis in Thai population .
17085896	0	growth_differentiation_factor_5	34,65	Gdf5	67,71	growth differentiation factor 5	Gdf5	14563(Tax:10090)	14563(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of mutation in the growth_differentiation_factor_5 -LRB- Gdf5 -RRB- gene in NC-brp/brp mice .
23849650	0	growth_differentiation_factor_9	14,45	GDF-9	47,52	growth differentiation factor 9	GDF-9	100313495(Tax:9615)	100313495(Tax:9615)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of growth_differentiation_factor_9 -LRB- GDF-9 -RRB- during in vitro maturation in canine oocytes .
21970812	0	growth_differentiation_factor_9	13,44	bone_morphogenetic_protein_15	46,75	growth differentiation factor 9	bone morphogenetic protein 15	282574(Tax:9913)	353351(Tax:9913)	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	The ratio of growth_differentiation_factor_9 : bone_morphogenetic_protein_15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates .
23266806	0	growth_differentiation_factor_9B	22,54	GDF9B	56,61	growth differentiation factor 9B	GDF9B	100141303(Tax:9940)	100141303(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism study of growth_differentiation_factor_9B -LRB- GDF9B -RRB- gene and its association with reproductive traits in sheep .
15252036	0	growth_factor_independence_1	105,133	Gfi1	135,139	growth factor independence 1	Gfi1	14581(Tax:10090)	14581(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gfi1 : green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth_factor_independence_1 -LRB- Gfi1 -RRB- gene during lymphocyte development .
18339716	0	growth_factor_receptor-bound_protein_14	27,66	grb14	68,73	growth factor receptor-bound protein 14	grb14	50915(Tax:10090)	50915(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Dual effect of the adapter growth_factor_receptor-bound_protein_14 -LRB- grb14 -RRB- on insulin action in primary hepatocytes .
19509291	0	growth_factor_receptor-bound_protein_2	35,73	GAREM	0,5	growth factor receptor-bound protein 2	GAREM	2885	64762	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	GAREM , a novel adaptor protein for growth_factor_receptor-bound_protein_2 , contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling .
8794768	0	growth_factor_receptor-bound_protein_2	53,91	Src	92,95	growth factor receptor-bound protein 2	Src	2885	6714	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Nuclear magnetic resonance solution structure of the growth_factor_receptor-bound_protein_2 Src homology 2 domain .
2158424	0	growth_hormone	20,34	Activin-A	0,9	growth hormone	Activin-A	81668(Tax:10116)	29200(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	Activin-A modulates growth_hormone secretion from cultures of rat anterior pituitary cells .
17085453	0	growth_hormone	65,79	AlphaCP1	0,8	growth hormone	AlphaCP1	2688	5093	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	AlphaCP1 mediates stabilization of hTERT mRNA by autocrine human growth_hormone .
3518864	0	growth_hormone	18,32	Bombesin	0,8	growth hormone	Bombesin	2688	2922	Gene	Gene	response|amod|START_ENTITY inhibits|dobj|response inhibits|nsubj|END_ENTITY	Bombesin inhibits growth_hormone response to insulin-induced hypoglycemia in humans .
6828206	0	growth_hormone	20,34	Bombesin	0,8	growth hormone	Bombesin	81668(Tax:10116)	2922	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Bombesin stimulates growth_hormone secretion from cultured bovine pituitary cells .
20680351	0	growth_hormone	71,85	CLCN5	8,13	growth hormone	CLCN5	2688	1184	Gene	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	A novel CLCN5 mutation in a boy with Bartter-like_syndrome and partial growth_hormone deficiency .
16408225	0	growth_hormone	18,32	CYP1A2	56,62	growth hormone	CYP1A2	2688	1544	Gene	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Lack of effect of growth_hormone replacement therapy on CYP1A2 and xanthine oxidase activities in growth_hormone-deficient children .
8156914	0	growth_hormone	61,75	CYP2C	27,32	growth hormone	CYP2C	81668(Tax:10116)	29277(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The sensitivity of hepatic CYP2C gene expression to baseline growth_hormone -LRB- GH -RRB- bioactivity in dwarf rats : effects of GH-binding protein in vivo .
9439609	0	growth_hormone	78,92	CYP3A9	37,43	growth hormone	CYP3A9	81668(Tax:10116)	171352(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Sexually dimorphic expression of rat CYP3A9 and CYP3A18 genes is regulated by growth_hormone .
1943449	0	growth_hormone	42,56	Corticotropin_releasing_factor	0,30	growth hormone	Corticotropin releasing factor	81668(Tax:10116)	81648(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Corticotropin_releasing_factor stimulates growth_hormone secretion in neonatal rats .
18300015	0	growth_hormone	10,24	Cyclooxygenase-2	28,44	growth hormone	Cyclooxygenase-2	81668(Tax:10116)	29527(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of growth_hormone on Cyclooxygenase-2 expression in the hippocampus of rats chronically exposed to ozone .
2521554	0	growth_hormone	58,72	Cytochrome_P450	0,15	growth hormone	Cytochrome P450	81668(Tax:10116)	25251(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Cytochrome_P450 in livers of diabetic rats : regulation by growth_hormone and insulin .
17485162	0	growth_hormone	14,28	Delta-like_protein_1	43,63	growth hormone	Delta-like protein 1	81668(Tax:10116)	114587(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of growth_hormone expression by Delta-like_protein_1 -LRB- Dlk1 -RRB- .
16107595	0	growth_hormone	31,45	Epidermal_growth_factor	0,23	growth hormone	Epidermal growth factor	2688	1950	Gene	Gene	START_ENTITY|nsubj|and/or and/or|compound|END_ENTITY	Epidermal_growth_factor and/or growth_hormone induce differential , side-specific signal transduction protein phosphorylation in enterocytes .
6611253	0	growth_hormone	35,49	Epidermal_growth_factor	0,23	growth hormone	Epidermal growth factor	81668(Tax:10116)	25313(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates growth_hormone secretion from superfused rat adenohypophyseal fragments .
22145450	0	growth_hormone	27,41	FGF23	18,23	growth hormone	FGF23	2688	8074	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Changes in plasma FGF23 in growth_hormone deficient children during rhGH therapy .
16772323	0	growth_hormone	37,51	FOXF1	21,26	growth hormone	FOXF1	2688	2294	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor FOXF1 regulates growth_hormone variant gene expression .
10084578	0	growth_hormone	18,32	GH	34,36	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Selective lack of growth_hormone -LRB- GH -RRB- response to the GH-releasing_peptide hexarelin in patients with GH-releasing hormone receptor deficiency .
10199767	0	growth_hormone	4,18	GH	20,22	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The growth_hormone -LRB- GH -RRB- response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH_deficiency .
10365112	0	growth_hormone	118,132	GH	134,136	growth hormone	GH	2688	2688	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Decreased serum levels of insulin-like_growth_factor _ -LRB- IGF -RRB- - I in patients with lung_cancer : temporal relationship with growth_hormone -LRB- GH -RRB- levels .
10468950	0	growth_hormone	76,90	GH	92,94	growth hormone	GH	2688	2688	Gene	Gene	excretion|amod|START_ENTITY excretion|appos|END_ENTITY	The impact of gender , puberty and body mass on reference values for urinary growth_hormone -LRB- GH -RRB- excretion in normally growing non-obese and obese children .
10484056	0	growth_hormone	50,64	GH	66,68	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Elevated insulin levels contribute to the reduced growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in obese subjects .
10752072	0	growth_hormone	11,25	GH	27,29	growth hormone	GH	2688	2688	Gene	Gene	Control|nmod|START_ENTITY Control|appos|END_ENTITY	Control of growth_hormone -LRB- GH -RRB- release by GH secretagogues .
10753592	0	growth_hormone	29,43	GH	45,47	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Glucocorticoid regulation of growth_hormone -LRB- GH -RRB- secretagogue-induced growth responses and GH secretagogue receptor expression in the rat .
10770194	0	growth_hormone	52,66	GH	68,70	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effects of short-term glucocorticoid deprivation on growth_hormone -LRB- GH -RRB- response to GH-releasing peptide-6 : studies in normal men and in patients with adrenal_insufficiency .
10780945	0	growth_hormone	13,27	GH	29,31	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Induction of growth_hormone -LRB- GH -RRB- mRNA by pulsatile GH-releasing hormone in rats is pattern specific .
10794128	0	growth_hormone	14,28	GH	30,32	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- secretion by different glutamate receptor subtypes in the rat .
10830294	0	growth_hormone	12,26	GH	28,30	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	High plasma growth_hormone -LRB- GH -RRB- levels inhibit expression of GH secretagogue receptor messenger ribonucleic_acid levels in the rat pituitary .
11225641	0	growth_hormone	23,37	GH	39,41	growth hormone	GH	2688	2688	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	Unfavourable impact of growth_hormone -LRB- GH -RRB- discontinuation on body composition and cholesterol profiles after the completion of height growth in GH-deficient young adults .
11297586	0	growth_hormone	75,89	GH	91,93	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Relationship between the morphological evaluation of the pituitary and the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone Plus arginine in children and adults with congenital_hypopituitarism .
11916628	0	growth_hormone	20,34	GH	36,38	growth hormone	GH	2688	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of different growth_hormone -LRB- GH -RRB- mutants on the regulation of GH-receptor gene transcription in a human hepatoma cell line .
12466380	0	growth_hormone	46,60	GH	62,64	growth hormone	GH	2688	2688	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Impact of experimental blockade of peripheral growth_hormone -LRB- GH -RRB- receptors on the kinetics of endogenous and exogenous GH removal in healthy women and men .
12519835	0	growth_hormone	10,24	GH	26,28	growth hormone	GH	2688	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- and/or testosterone replacement on the prostate in GH-deficient adult patients .
12608936	0	growth_hormone	14,28	GH	30,32	growth hormone	GH	2688	2688	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of growth_hormone -LRB- GH -RRB- replacement therapy in adult patients with type_1_diabetes_mellitus and GH_deficiency .
12679475	0	growth_hormone	10,24	GH	26,28	growth hormone	GH	2688	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on glycerol and free fatty_acid metabolism during exhaustive exercise in GH-deficient adults .
12840904	0	growth_hormone	13,27	GH	29,31	growth hormone	GH	2688	2688	Gene	Gene	START_ENTITY|dobj|effect effect|appos|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
12957475	0	growth_hormone	82,96	GH	98,100	growth hormone	GH	100305005(Tax:7998)	100305005(Tax:7998)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Development of an enzyme-linked immunosorbent assay for the measurement of plasma growth_hormone -LRB- GH -RRB- levels in channel_catfish -LRB- Ictalurus_punctatus -RRB- : assessment of environmental salinity and GH secretogogues on plasma GH levels .
1400881	0	growth_hormone	6,20	GH	22,24	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Acute growth_hormone -LRB- GH -RRB- response to GH-releasing hexapeptide in humans is independent of endogenous GH-releasing hormone .
1454656	0	growth_hormone	15,29	GH	31,33	growth hormone	GH	2688	2688	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
14557454	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	2688	2688	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Sexual dimorphism of growth_hormone -LRB- GH -RRB- regulation in humans : endogenous GH-releasing hormone maintains basal GH in women but not in men .
14602749	0	growth_hormone	11,25	GH	27,29	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on ghrelin , leptin , and adiponectin in GH-deficient patients .
14751587	0	growth_hormone	23,37	GH	39,41	growth hormone	GH	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Age-related changes in growth_hormone -LRB- GH -RRB- cells in the pituitary gland of male mice are mediated by GH-releasing hormone but not by somatostatin in the hypothalamus .
1517388	0	growth_hormone	27,41	GH	43,45	growth hormone	GH	2688	2688	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations in spontaneous growth_hormone -LRB- GH -RRB- secretion and the response to GH-releasing hormone in children with nonorganic nutritional_dwarfing .
15242989	0	growth_hormone	8,22	GH	24,26	growth hormone	GH	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of growth_hormone -LRB- GH -RRB- in liver_regeneration .
15305235	0	growth_hormone	27,41	GH	43,45	growth hormone	GH	2688	2688	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Age-related differences in growth_hormone -LRB- GH -RRB- regulation during strenuous exercise .
15464751	0	growth_hormone	23,37	GH	39,41	growth hormone	GH	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Age-related changes in growth_hormone -LRB- GH -RRB- - releasing hormone and somatostatin neurons in the hypothalamus and in GH cells in the anterior pituitary of female mice .
15472470	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	102171600	102171600	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- pulses in the peripheral circulation and GH-releasing_hormone and somatostatin profiles in the cerebrospinal fluid of goats .
15486811	0	growth_hormone	11,25	GH	27,29	growth hormone	GH	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on mRNA levels of uncoupling proteins 1 , 2 , and 3 in brown and white_adipose_tissues and skeletal muscle in obese mice .
15504394	0	growth_hormone	11,25	GH	32,34	growth hormone	GH	378781(Tax:9031)	378781(Tax:9031)	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Testicular growth_hormone -LRB- GH -RRB- : GH expression in spermatogonia and primary spermatocytes .
15531488	0	growth_hormone	28,42	GH	44,46	growth hormone	GH	2688	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of recombinant human growth_hormone -LRB- GH -RRB- replacement on the hypothalamic-pituitary-adrenal_axis in adult GH-deficient patients .
15629012	0	growth_hormone	39,53	GH	55,57	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The level of physical activity and the growth_hormone -LRB- GH -RRB- response to acute physical exercise .
1576976	0	growth_hormone	48,62	GH	64,66	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The relationship between beta-endorphin and the growth_hormone -LRB- GH -RRB- response to GH releasing hormone in prepubertal children .
1576976	0	growth_hormone	48,62	GH	80,82	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	The relationship between beta-endorphin and the growth_hormone -LRB- GH -RRB- response to GH releasing hormone in prepubertal children .
15879358	0	growth_hormone	85,99	GH	34,36	growth hormone	GH	2688	2688	Gene	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	Seasonality of growth response to GH therapy in prepubertal children with idiopathic growth_hormone deficiency .
1592867	0	growth_hormone	31,45	GH	47,49	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Influence of pyridostigmine on growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone pre - and postprandially in normal and obese subjects .
1592874	0	growth_hormone	24,38	GH	40,42	growth hormone	GH	2688	2688	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Arginine normalizes the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in adult patients receiving chronic daily immunosuppressive glucocorticoid therapy .
1592893	0	growth_hormone	65,79	GH	81,83	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Sleep , awakenings , and insulin-like_growth_factor-I modulate the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing_hormone .
16059977	0	growth_hormone	30,44	GH	46,48	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of recombinant human growth_hormone -LRB- GH -RRB- replacement therapy on bone metabolism in children with GH_deficiency -RSB- .
16444180	0	growth_hormone	10,24	GH	26,28	growth hormone	GH	2688	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on the immune system .
1671784	0	growth_hormone	42,56	GH	58,60	growth hormone	GH	2688	2688	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Reliability of stimulated and spontaneous growth_hormone -LRB- GH -RRB- levels for identifying the child with low GH secretion .
1714828	0	growth_hormone	29,43	GH	45,47	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of growth_hormone -LRB- GH -RRB- receptor messenger ribonucleic acid -LRB- mRNA -RRB- in rat adipose tissue , adipocytes , and adipocyte precursor cells : GH regulation of GH_receptor mRNA .
17381489	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	2688	2688	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Long-term effects of growth_hormone -LRB- GH -RRB- on bone mineral status and bone turnover markers in patients with isolated_GH_deficiency and multiple_pituitary_hormone_deficiency .
17456794	0	growth_hormone	12,26	GH	28,30	growth hormone	GH	2688	2688	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Role of the growth_hormone -LRB- GH -RRB- receptor transmembrane domain in receptor predimerization and GH-induced activation .
18029459	0	growth_hormone	13,27	GH	29,31	growth hormone	GH	2688	2688	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of growth_hormone -LRB- GH -RRB- receptor deletion of exon 3 and full-length isoforms on GH response and final height in patients with severe GH_deficiency .
18765508	0	growth_hormone	36,50	GH	52,54	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The effects of central adiposity on growth_hormone -LRB- GH -RRB- response to GH-releasing hormone-arginine stimulation testing in men .
18777498	0	growth_hormone	29,43	GH	45,47	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of one-year low-dose growth_hormone -LRB- GH -RRB- therapy on body composition , lipid profile and carbohydrate metabolism in young adults with childhood-onset severe GH_deficiency confirmed after completion of growth promotion .
1879666	0	growth_hormone	52,66	GH	161,163	growth hormone	GH	2688	2688	Gene	Gene	Distribution|nmod|START_ENTITY END_ENTITY|nsubj|Distribution	Distribution and characterization of immunoreactive growth_hormone -LRB- GH -RRB- in the pituitary of the frog Rana ridibunda using an antiserum against purified bullfrog GH .
1879666	0	growth_hormone	52,66	GH	68,70	growth hormone	GH	2688	2688	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and characterization of immunoreactive growth_hormone -LRB- GH -RRB- in the pituitary of the frog Rana ridibunda using an antiserum against purified bullfrog GH .
1955500	0	growth_hormone	58,72	GH	74,76	growth hormone	GH	2688	2688	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Dexamethasone treatment in man induces changes in 24-hour growth_hormone -LRB- GH -RRB- secretion profile without altering total GH released .
1977761	0	growth_hormone	40,54	GH	56,58	growth hormone	GH	2688	2688	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Alpha 2-adrenergic agonism enhances the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone through an inhibition of hypothalamic somatostatin release in normal men .
20061428	0	growth_hormone	89,103	GH	105,107	growth hormone	GH	2688	2688	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth_hormone -LRB- GH -RRB- - treated children with Prader-Willi_syndrome and in non-GH-treated obese children .
20146168	0	growth_hormone	10,24	GH	26,28	growth hormone	GH	2688	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on fasting and postprandial metabolism in GH_deficiency .
20529604	0	growth_hormone	96,110	GH	112,114	growth hormone	GH	2688	2688	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Observation of children with total or partial somatotropic pituitary_hypofunction treated with growth_hormone -LRB- GH -RRB- -RSB- .
21073120	0	growth_hormone	43,57	GH	59,61	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	GHR and VDR genes do not contribute to the growth_hormone -LRB- GH -RRB- response in GH deficient_and_Turner_syndrome patients .
2143200	0	growth_hormone	10,24	GH	131,133	growth hormone	GH	2688	2688	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Perinatal growth_hormone -LRB- GH -RRB- physiology : effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH .
21637543	0	growth_hormone	65,79	GH	81,83	growth hormone	GH	102171600	102171600	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of two single nucleotide polymorphisms -LRB- SNPs -RRB- in growth_hormone -LRB- GH -RRB- gene with litter size and superovulation response in goat-breeds .
2180981	0	growth_hormone	11,25	GH	27,29	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on plasma bone_Gla_protein in GH-deficient adults .
22120536	0	growth_hormone	63,77	GH	79,81	growth hormone	GH	103387754	103387754	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure , polymorphism and expression analysis of the growth_hormone -LRB- GH -RRB- gene in female and male Half-smooth_tongue_sole -LRB- Cynoglossus_semilaevis -RRB- .
2226343	0	growth_hormone	14,28	GH	30,32	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Change in the growth_hormone -LRB- GH -RRB- response to GH-releasing_factor -LRB- GRF -RRB- caused by exogenous GH in short children .
2258583	0	growth_hormone	46,60	GH	62,64	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of acipimox , a lipid lowering drug , on growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal subjects .
2284886	0	growth_hormone	36,50	GH	52,54	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effects of methimazole treatment on growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in patients with hyperthyroidism .
23262274	0	growth_hormone	28,42	GH	44,46	growth hormone	GH	378781(Tax:9031)	378781(Tax:9031)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neuro-protective effects of growth_hormone -LRB- GH -RRB- after hypoxia-ischemia injury in embryonic chicken cerebellum .
2387255	0	growth_hormone	14,28	GH	30,32	growth hormone	GH	2688	2688	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- bioactivity by a recombinant human GH-binding_protein .
23970781	0	growth_hormone	35,49	GH	107,109	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of zinc binding residues in growth_hormone -LRB- GH -RRB- and altered intracellular zinc content on regulated GH secretion .
2415346	0	growth_hormone	11,25	GH	27,29	growth hormone	GH	2688	2688	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of growth_hormone -LRB- GH -RRB- from purified somatotrophs : interaction of GH-releasing factor and somatostatin and role of adenosine_3 ' ,5 ' - monophosphate .
2491803	2	growth_hormone	111,125	GH	127,129	growth hormone	GH	443329(Tax:9940)	443329(Tax:9940)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of age , breeding season , and twinning on the growth_hormone -LRB- GH -RRB- response to GH-releasing factor : evidence for a homeostatic role of fetal GH .
2492921	0	growth_hormone	24,38	GH	40,42	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of pulsatile growth_hormone -LRB- GH -RRB- secretion and somatic growth in immature rats with a synthetic GH-releasing factor antagonist .
2506218	0	growth_hormone	83,97	GH	99,101	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Repetitive growth_hormone-releasing_hormone administration restores the attenuated growth_hormone -LRB- GH -RRB- response to GH-releasing hormone testing in normal aging .
2545765	0	growth_hormone	22,36	GH	38,40	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Calcitonin suppresses growth_hormone -LRB- GH -RRB- response to growth_hormone-releasing hormone -LRB- GHRH -RRB- in man .
2562828	0	growth_hormone	14,28	GH	30,32	growth hormone	GH	2688	2688	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- secretion by GH-releasing factor , somatostatin , and insulin-like_growth_factor_I in ovine fetal and neonatal pituitary cells in vitro .
2563681	2	growth_hormone	89,103	GH	105,107	growth hormone	GH	443329(Tax:9940)	443329(Tax:9940)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The effect of somatostatin on the growth_hormone -LRB- GH -RRB- response to GH-releasing factor .
2565914	0	growth_hormone	18,32	GH	34,36	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Inhibition of the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone by constant Met-GH infusions .
2566942	0	growth_hormone	113,127	GH	129,131	growth hormone	GH	2688	2688	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2570721	0	growth_hormone	32,46	GH	48,50	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Ultrastructural distribution of growth_hormone -LRB- GH -RRB- mRNA and GH intron I sequences in rat pituitary gland : effects of GH releasing factor and somatostatin .
2591065	0	growth_hormone	26,40	GH	42,44	growth hormone	GH	2688	2688	Gene	Gene	excretion|amod|START_ENTITY excretion|appos|END_ENTITY	Quantification of urinary growth_hormone -LRB- GH -RRB- excretion by centrifugal ultrafiltration and radioimmunoassay : appraisal of the relationship between 24 h urinary GH and mean 24 h serum GH levels in normal and abnormal states of GH secretion .
26511947	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	2688	2688	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Long-term effects of growth_hormone -LRB- GH -RRB- replacement therapy on hematopoiesis in a large cohort of children with GH_deficiency .
2809099	0	growth_hormone	11,25	GH	27,29	growth hormone	GH	2688	2688	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in growth_hormone -LRB- GH -RRB- secretion and in growth during puberty .
2881773	0	growth_hormone	33,47	GH	49,51	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	suppression|amod|START_ENTITY suppression|appos|END_ENTITY	Mechanisms of calcitonin-induced growth_hormone -LRB- GH -RRB- suppression : roles of somatostatin_and_GH-releasing_factor .
2883595	0	growth_hormone	106,120	GH	122,124	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2901338	0	growth_hormone	75,89	GH	91,93	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Delayed release formulation of the somatostatin analog RC-160 inhibits the growth_hormone -LRB- GH -RRB- response to GH-releasing factor - -LRB- 1-29 -RRB- NH2 and decreases elevated prolactin levels in rats .
2906083	0	growth_hormone	23,37	GH	39,41	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	The rebound release of growth_hormone -LRB- GH -RRB- following somatostatin infusion in rats involves hypothalamic GH-releasing_factor release .
3000727	0	growth_hormone	13,27	GH	29,31	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of growth_hormone -LRB- GH -RRB- receptors in adipocytes of hypophysectomized rats by GH .
3075099	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	2688	2688	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Modulating effect of growth_hormone -LRB- GH -RRB- on PHA-induced lymphocyte proliferation .
3079770	0	growth_hormone	9,23	GH	25,27	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Impaired growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in thalassemia major .
3082919	0	growth_hormone	19,33	GH	35,37	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Suppression of the growth_hormone -LRB- GH -RRB- response to clonidine and GH-releasing hormone by exogenous GH .
3085872	0	growth_hormone	69,83	GH	85,87	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Effects of neonatal administration of monosodium_glutamate on plasma growth_hormone -LRB- GH -RRB- response to GH-releasing_factor in adult male and female rats .
3091629	0	growth_hormone	90,104	GH	106,108	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The effect of pulsatile administration , continuous infusion , and diurnal variation on the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal men .
3100282	0	growth_hormone	26,40	GH	42,44	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of estrogen on the growth_hormone -LRB- GH -RRB- secretory response to GH-releasing factor in the castrate adult female rat in vivo .
3126213	0	growth_hormone	33,47	GH	71,73	growth hormone	GH	2688	2688	Gene	Gene	administration|compound|START_ENTITY effects|nmod|administration effects|nmod|END_ENTITY	The effects of acute and chronic growth_hormone -LRB- GH -RRB- administration on GH secretion in patients with idiopathic_GH_deficiency .
3127419	0	growth_hormone	66,80	GH	82,84	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Differential effects of feeding on the ultradian variation of the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal subjects and patients with obesity and anorexia_nervosa .
3135487	0	growth_hormone	23,37	GH	39,41	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Feedback regulation of growth_hormone -LRB- GH -RRB- - releasing hormone gene expression by GH in rat hypothalamus .
3141549	0	growth_hormone	42,56	GH	58,60	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Phorbol_ester pretreatment attenuates the growth_hormone -LRB- GH -RRB- response to GH-releasing_factor in cultured rat pituitary cells .
3142918	0	growth_hormone	28,42	GH	44,46	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Inhibition by prednisone of growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in normal men .
3425315	0	growth_hormone	47,61	GH	63,65	growth hormone	GH	2688	2688	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A longitudinal study on growth and spontaneous growth_hormone -LRB- GH -RRB- secretion in children with irradiated brain_tumors .
3654910	0	growth_hormone	26,40	GH	132,134	growth hormone	GH	2688	2688	Gene	Gene	START_ENTITY|nmod|elevation elevation|nmod|END_ENTITY	Characterization of serum growth_hormone -LRB- GH -RRB- and insulin-like_growth_factor_I in active acromegaly with minimal elevation of serum GH .
3926807	0	growth_hormone	8,22	GH	24,26	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Blunted growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in hypothyroidism resolves in the euthyroid state .
7525625	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	2688	2688	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of human growth_hormone -LRB- GH -RRB- administration in GH-deficient adults : a 20-day metabolic ward study .
7629249	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Acipimox potentiates growth_hormone -LRB- GH -RRB- response to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty_acid in normal and obese subjects .
7681769	0	growth_hormone	25,39	GH	41,43	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of galanin on the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in patients with Cushing 's _ disease .
7714096	0	growth_hormone	14,28	GH	30,32	growth hormone	GH	2688	2688	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Screening for growth_hormone -LRB- GH -RRB- gene splice-site mutations in sporadic cases with severe isolated_GH_deficiency using ectopic transcript analysis .
7829600	0	growth_hormone	29,43	GH	167,169	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of recombinant human growth_hormone -LRB- GH -RRB- on bone and intermediary metabolism in patients receiving chronic glucocorticoid treatment with suppressed endogenous GH response to GH-releasing hormone .
7829600	0	growth_hormone	29,43	GH	45,47	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of recombinant human growth_hormone -LRB- GH -RRB- on bone and intermediary metabolism in patients receiving chronic glucocorticoid treatment with suppressed endogenous GH response to GH-releasing hormone .
7835299	0	growth_hormone	11,25	GH	27,29	growth hormone	GH	2688	2688	Gene	Gene	Control|nmod|START_ENTITY Control|appos|END_ENTITY	Control of growth_hormone -LRB- GH -RRB- binding protein release from human hepatoma cells expressing full-length GH_receptor .
7901787	0	growth_hormone	26,40	GH	42,44	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
7903312	0	growth_hormone	56,70	GH	72,74	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Somatostatin receptors , adenylate cyclase activity , and growth_hormone -LRB- GH -RRB- response to octreotide in GH-secreting adenomas .
7907904	0	growth_hormone	39,53	GH	55,57	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Different effects of pyridostigmine on growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in endogenous and exogenous hypercortisolemic patients .
8263146	0	growth_hormone	32,46	GH	48,50	growth hormone	GH	2688	2688	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Marked effects of sustained low growth_hormone -LRB- GH -RRB- levels on day-to-day fuel metabolism : studies in GH-deficient patients and healthy untreated subjects .
8513607	0	growth_hormone	63,77	GH	79,81	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
8606641	0	growth_hormone	51,65	GH	67,69	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effects of acipimox , an antilipolytic drug , on the growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone alone or combined with arginine in obesity .
8626871	0	growth_hormone	16,30	GH	32,34	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The decrease in growth_hormone -LRB- GH -RRB- response after repeated stimulation with GH-releasing hormone is partly caused by an elevation of somatostatin tonus .
8628114	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of galanin on growth_hormone -LRB- GH -RRB- response to thyrotropin releasing hormone of rat pituitary GH-secreting adenomatous cells -LRB- GH1 -RRB- in culture .
8636340	0	growth_hormone	29,43	GH	45,47	growth hormone	GH	2688	2688	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Dose-dependent inhibition of growth_hormone -LRB- GH -RRB- - releasing hormone-induced GH release by corticotropin-releasing_hormone in prepubertal children .
8654647	0	growth_hormone	33,47	GH	49,51	growth hormone	GH	2688	2688	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Gonadal function and response to growth_hormone -LRB- GH -RRB- in boys with isolated_GH_deficiency and to GH and gonadotropins in boys with multiple_pituitary_hormone_deficiencies .
8768878	0	growth_hormone	24,38	GH	40,42	growth hormone	GH	2688	2688	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of long-term growth_hormone -LRB- GH -RRB- treatment on bone_mineral_density in children with GH_deficiency .
8816035	0	growth_hormone	19,33	GH	35,37	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
8905475	0	growth_hormone	23,37	GH	39,41	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of recombinant growth_hormone -LRB- GH -RRB- treatment on bone_mineral_density and body composition in adults with childhood onset growth_hormone_deficiency .
8923850	0	growth_hormone	15,29	GH	31,33	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Restoration of growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in elderly and obese subjects by acute pharmacological reduction of plasma free fatty_acids .
8985666	0	growth_hormone	42,56	GH	58,60	growth hormone	GH	443329(Tax:9940)	443329(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The effects of a duplication in the ovine growth_hormone -LRB- GH -RRB- gene on GH expression in the pituitaries of ram lambs from lean and fat-selected sheep lines .
9078817	0	growth_hormone	68,82	GH	84,86	growth hormone	GH	2688	2688	Gene	Gene	_|amod|START_ENTITY diagnosis|nmod|_ screening|nmod|diagnosis screening|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- screening for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency .
9100588	0	growth_hormone	37,51	GH	53,55	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of obesity and feeding on the growth_hormone -LRB- GH -RRB- response to the GH secretagogue L-692 ,429 in young men .
9112397	0	growth_hormone	17,31	GH	33,35	growth hormone	GH	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Liver and kidney growth_hormone -LRB- GH -RRB- receptors are regulated differently in diabetic_GH and GH_antagonist transgenic_mice .
9125486	0	growth_hormone	46,60	GH	73,75	growth hormone	GH	2688	2688	Gene	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Effect of chronic treatment with biosynthetic growth_hormone -LRB- GH -RRB- on the GH response to double GH-releasing_hormone administration in children with short_stature .
9140905	0	growth_hormone	32,46	GH	48,50	growth hormone	GH	2688	2688	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Exercise training decreases the growth_hormone -LRB- GH -RRB- response to acute constant-load exercise .
9144201	0	growth_hormone	11,25	GH	107,109	growth hormone	GH	14599(Tax:10090)	14599(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Functional growth_hormone -LRB- GH -RRB- receptors and GH are expressed by preimplantation mouse embryos : a role for GH in early embryogenesis ?
9177389	0	growth_hormone	14,28	GH	30,32	growth hormone	GH	2688	2688	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of growth_hormone -LRB- GH -RRB- on histomorphometric indices of bone_structure_and_bone_turnover in GH-deficient men .
9215300	0	growth_hormone	76,90	GH	92,94	growth hormone	GH	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Evidence for an inhibitory effect of physiological levels of insulin on the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in healthy subjects .
9302388	0	growth_hormone	21,35	GH	37,39	growth hormone	GH	2688	2688	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- status , serum leptin and body composition in healthy and GH_deficient elderly subjects .
9348244	0	growth_hormone	25,39	GH	41,43	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Quantitative analysis of growth_hormone -LRB- GH -RRB- pre-mRNA expression in cultured rat anterior pituitary cells by an intron-specific and competitive PCR method .
9745423	0	growth_hormone	25,39	GH	41,43	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of physiological growth_hormone -LRB- GH -RRB- therapy on cognition and quality of life in patients with adult-onset GH_deficiency .
9892845	0	growth_hormone	8,22	GH	24,26	growth hormone	GH	81668(Tax:10116)	81668(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of growth_hormone -LRB- GH -RRB- - releasing hormone and somatostatin on leptin-induced GH secretion .
9920068	0	growth_hormone	36,50	GH	52,54	growth hormone	GH	2688	2688	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of 20-kilodalton human growth_hormone -LRB- GH -RRB- are parallel those of 22-kilodalton human GH in normal and short children .
9920097	0	growth_hormone	76,90	GH	92,94	growth hormone	GH	2688	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of recombinant human insulin-like_growth_factor_I administration on growth_hormone -LRB- GH -RRB- secretion , both spontaneous and stimulated by GH-releasing hormone or hexarelin , a peptidyl GH secretagogue , in humans .
2040861	0	growth_hormone	53,67	GH-receptor	76,87	growth hormone	GH-receptor	378781(Tax:9031)	408184(Tax:9031)	Gene	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of hypophysectomy and acute administration of growth_hormone -LRB- GH -RRB- on GH-receptor binding in chick liver membranes .
2108443	0	growth_hormone	64,78	GH-releasing_hormone	91,111	growth hormone	GH-releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Age-related modulatory activity by a cholinergic agonist on the growth_hormone response to GH-releasing_hormone in the rat .
3079770	0	growth_hormone	9,23	GH-releasing_hormone	41,61	growth hormone	GH-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Impaired growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in thalassemia major .
3926807	0	growth_hormone	8,22	GH-releasing_hormone	40,60	growth hormone	GH-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Blunted growth_hormone -LRB- GH -RRB- response to GH-releasing_hormone in hypothyroidism resolves in the euthyroid state .
9503036	0	growth_hormone	32,46	GH-releasing_hormone	73,93	growth hormone	GH-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY secretion|acl|induced induced|nmod|END_ENTITY	Opioid-receptor blockade blunts growth_hormone -LRB- GH -RRB- secretion induced by GH-releasing_hormone in the human male .
17223997	0	growth_hormone	6,20	GH1	22,25	growth hormone	GH1	2688	2688	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	Human growth_hormone -LRB- GH1 -RRB- gene polymorphism map in a normal-statured adult population .
1730572	0	growth_hormone	49,63	GH1	77,80	growth hormone	GH1	81668(Tax:10116)	24391(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|cells cells|nummod|END_ENTITY	Thyroid_hormone and apotransferrin regulation of growth_hormone secretion by GH1 rat pituitary_tumor cells in iron restricted serum-free defined medium .
7399546	0	growth_hormone	14,28	GH1	45,48	growth hormone	GH1	81668(Tax:10116)	24391(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|nummod|END_ENTITY	Evaluation of growth_hormone production from GH1 cells in vitro : effect of culture media and time in culture .
9765286	0	growth_hormone	43,57	GHF-1	8,13	growth hormone	GHF-1	81668(Tax:10116)	25517(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of GHF-1 in the regulation of the rat growth_hormone gene promoter by thyroid hormone and retinoic_acid receptors .
10594518	0	growth_hormone	125,139	GHRH	67,71	growth hormone	GHRH	2688	2691	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|growth_hormone-releasing_hormone growth_hormone-releasing_hormone|dep|END_ENTITY	The relative roles of continuous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- and intermittent somatostatin -LRB- 1-14 -RRB- -LRB- SS -RRB- in growth_hormone -LRB- GH -RRB- pulse generation : studies in normal and post cranial irradiated individuals .
10770183	0	growth_hormone	13,27	GHRH	168,172	growth hormone	GHRH	2688	2691	Gene	Gene	_|amod|START_ENTITY Diagnosis|nmod|_ _|nsubj|Diagnosis _|nmod|hypothalamic-pituitary_disorders hypothalamic-pituitary_disorders|dep|comparison comparison|nmod|results results|acl|using using|dobj|hormone hormone|appos|END_ENTITY	Diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in adults with hypothalamic-pituitary_disorders : comparison of test results using pyridostigmine plus GH-releasing hormone -LRB- GHRH -RRB- , clonidine plus GHRH , and insulin-induced hypoglycemia as GH secretagogues .
12740741	0	growth_hormone	102,116	GHRH	60,64	growth hormone	GHRH	2688	2691	Gene	Gene	response|nmod|START_ENTITY Involvement|nmod|response Involvement|appos|END_ENTITY	Involvement of endogenous growth_hormone-releasing_hormone -LRB- GHRH -RRB- in the exercise-related response of growth_hormone .
12840904	0	growth_hormone	13,27	GHRH	75,79	growth hormone	GHRH	2688	2691	Gene	Gene	START_ENTITY|dobj|effect effect|appos|END_ENTITY	TPA enhances growth_hormone -LRB- GH -RRB- secretion effect of GH-releasing_hormone -LRB- GHRH -RRB- by human gsp-positive pituitary_somatotrophinomas .
12864804	0	growth_hormone	89,103	GHRH	32,36	growth hormone	GHRH	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY diagnosing|dobj|deficiency test|acl|diagnosing test|advcl|test test|nsubj|effectiveness effectiveness|nmod|END_ENTITY	The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth_hormone deficiency in adults .
12864804	0	growth_hormone	89,103	GHRH	56,60	growth hormone	GHRH	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY diagnosing|dobj|deficiency test|acl|diagnosing test|compound|END_ENTITY	The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth_hormone deficiency in adults .
1454656	0	growth_hormone	15,29	GHRH	47,51	growth hormone	GHRH	2688	2691	Gene	Gene	Inhibition|nmod|START_ENTITY response|nsubj|Inhibition response|xcomp|END_ENTITY	-LSB- Inhibition of growth_hormone -LRB- GH -RRB- response to GHRH in diabetes_mellitus_type_1 after blockade of the cholinergic system with pirenzepine -RSB- .
1553429	0	growth_hormone	25,39	GHRH	74,78	growth hormone	GHRH	403795(Tax:9615)	485863(Tax:9615)	Gene	Gene	response|amod|START_ENTITY propranolol|nmod|response Effect|nmod|propranolol Effect|appos|END_ENTITY	Effect of propranolol on growth_hormone response to GH_releasing_hormone -LRB- GHRH 1-44 -RRB- in the dog .
15564325	0	growth_hormone	25,39	GHRH	136,140	growth hormone	GHRH	14599(Tax:10090)	14601(Tax:10090)	Gene	Gene	_|amod|START_ENTITY reversibility|nmod|_ _|nsubj|reversibility _|nmod|analog analog|compound|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15564325	0	growth_hormone	25,39	GHRH	85,89	growth hormone	GHRH	14599(Tax:10090)	14601(Tax:10090)	Gene	Gene	_|amod|START_ENTITY reversibility|nmod|_ _|nsubj|reversibility _|nmod|mouse mouse|appos|END_ENTITY	Partial reversibility of growth_hormone _ -LRB- GH -RRB- _ deficiency in the GH-releasing_hormone -LRB- GHRH -RRB- knockout mouse by postnatal treatment with a GHRH analog .
15809015	0	growth_hormone	23,37	GHRH	64,68	growth hormone	GHRH	2688	2691	Gene	Gene	Circulating|dobj|START_ENTITY isoforms|csubj|Circulating isoforms|nmod|stimulus stimulus|compound|END_ENTITY	Circulating non-22 kDa growth_hormone isoforms after a repeated GHRH stimulus in normal subjects .
15979916	0	growth_hormone	29,43	GHRH	88,92	growth hormone	GHRH	14599(Tax:10090)	14601(Tax:10090)	Gene	Gene	START_ENTITY|ccomp|knock knock|nsubj|treatment treatment|nmod|composition composition|nmod|END_ENTITY	Effects of recombinant mouse growth_hormone treatment on growth and body composition in GHRH knock out mice .
16712669	0	growth_hormone	44,58	GHRH	99,103	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|amod|START_ENTITY obesity|nmod|secretion Effect|nmod|obesity elicited|nsubj|Effect elicited|nmod|test test|compound|END_ENTITY	Effect of obesity and morbid obesity on the growth_hormone -LRB- GH -RRB- secretion elicited by the combined GHRH + GHRP-6 test .
1890280	0	growth_hormone	22,36	GHRH	55,59	growth hormone	GHRH	2688	2691	Gene	Gene	Restoration|nmod|START_ENTITY responsiveness|nsubj|Restoration responsiveness|xcomp|END_ENTITY	Restoration of normal growth_hormone responsiveness to GHRH in normal aged men by infusion of low amounts of theophylline .
1943453	0	growth_hormone	7,21	GHRH	133,137	growth hormone	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	secretion|nsubj|START_ENTITY secretion|dep|END_ENTITY	Robust growth_hormone -LRB- GH -RRB- secretion in aged female rats co-administered GH-releasing hexapeptide -LRB- GHRP-6 -RRB- and GH-releasing_hormone -LRB- GHRH -RRB- .
20843274	0	growth_hormone	14,28	GHRH	221,225	growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY Difference|nmod|response GHRH|amod|Difference GHRH|dep|perspectives perspectives|nmod|use use|nmod|END_ENTITY	Difference in growth_hormone response to growth_hormone-releasing hormone -LRB- GHRH -RRB- testing following GHRH subacute treatment in normal aging and growth_hormone-deficient adults : possible perspectives for therapeutic use of GHRH or its analogs in elderly subjects ?
20843274	0	growth_hormone	14,28	GHRH	75,79	growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY Difference|nmod|response Difference|nmod|hormone hormone|appos|END_ENTITY	Difference in growth_hormone response to growth_hormone-releasing hormone -LRB- GHRH -RRB- testing following GHRH subacute treatment in normal aging and growth_hormone-deficient adults : possible perspectives for therapeutic use of GHRH or its analogs in elderly subjects ?
20843274	0	growth_hormone	14,28	GHRH	99,103	growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY Difference|nmod|response END_ENTITY|amod|Difference	Difference in growth_hormone response to growth_hormone-releasing hormone -LRB- GHRH -RRB- testing following GHRH subacute treatment in normal aging and growth_hormone-deficient adults : possible perspectives for therapeutic use of GHRH or its analogs in elderly subjects ?
2113855	0	growth_hormone	20,34	GHRH	85,89	growth hormone	GHRH	2688	2691	Gene	Gene	responses|amod|START_ENTITY Discordance|nmod|responses Discordance|nmod|hormone hormone|appos|END_ENTITY	Discordance between growth_hormone responses after growth_hormone-releasing hormone -LRB- GHRH -RRB- and insulin_hypoglycemia in ectopic_GHRH_syndrome .
2114240	0	growth_hormone	35,49	GHRH	87,91	growth hormone	GHRH	2688	2691	Gene	Gene	glucose|nmod|START_ENTITY Effect|nmod|glucose rise|nsubj|Effect rise|dobj|responses responses|acl|END_ENTITY	Effect of oral glucose on the late growth_hormone rise and growth_hormone responses to GHRH in normal subjects .
2273206	0	growth_hormone	62,76	GHRH	115,119	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|nmod|START_ENTITY Interaction|nmod|secretion induced|nsubj|Interaction induced|nmod|GH-releasing_hormone GH-releasing_hormone|appos|END_ENTITY	Interaction of glucose and pyridostigmine on the secretion of growth_hormone -LRB- GH -RRB- induced by GH-releasing_hormone -LRB- GHRH -RRB- .
2497615	0	growth_hormone	40,54	GHRH	67,71	growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Influence of estrogen administration on growth_hormone response to GHRH and L-Dopa in patients with Turner 's _ syndrome .
2498860	0	growth_hormone	74,88	GHRH	112,116	growth hormone	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	START_ENTITY|acl:relcl|responsiveness responsiveness|xcomp|END_ENTITY	Replenishment of brain catecholamine stores does not restore the impaired growth_hormone -LRB- GH -RRB- responsiveness to GHRH in aged rats .
2515143	0	growth_hormone	110,124	GHRH	81,85	growth hormone	GHRH	2688	2691	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of acute intravenous injection of two growth_hormone-releasing hormones -LRB- GHRH 1-40 and 1-29 -RRB- on serum growth_hormone and other pituitary hormones in short children with pulsatile growth_hormone secretion .
2515143	0	growth_hormone	187,201	GHRH	81,85	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|compound|START_ENTITY children|nmod|secretion growth_hormone|nmod|children Effects|nmod|growth_hormone Effects|dep|END_ENTITY	Effects of acute intravenous injection of two growth_hormone-releasing hormones -LRB- GHRH 1-40 and 1-29 -RRB- on serum growth_hormone and other pituitary hormones in short children with pulsatile growth_hormone secretion .
2545765	0	growth_hormone	22,36	GHRH	88,92	growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|hormone hormone|appos|END_ENTITY	Calcitonin suppresses growth_hormone -LRB- GH -RRB- response to growth_hormone-releasing hormone -LRB- GHRH -RRB- in man .
2546369	0	growth_hormone	102,116	GHRH	65,69	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|amod|START_ENTITY augment|dobj|secretion infusions|ccomp|augment infusions|nsubj|growth_hormone-releasing_hormone growth_hormone-releasing_hormone|dep|END_ENTITY	Use of continuous subcutaneous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- infusions to augment growth_hormone secretion and to promote growth .
2546370	0	growth_hormone	176,190	GHRH	125,129	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|compound|START_ENTITY children|nmod|secretion subcutaneous|nmod|children subcutaneous|parataxis|END_ENTITY	Modification of 24-hour growth_hormone secretion after continuous subcutaneous infusion of growth_hormone-releasing hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- in short children with low 24-hour growth_hormone secretion .
2546370	0	growth_hormone	24,38	GHRH	125,129	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|compound|START_ENTITY Modification|nmod|secretion subcutaneous|nsubj|Modification subcutaneous|parataxis|END_ENTITY	Modification of 24-hour growth_hormone secretion after continuous subcutaneous infusion of growth_hormone-releasing hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- in short children with low 24-hour growth_hormone secretion .
2565570	0	growth_hormone	85,99	GHRH	112,116	growth hormone	GHRH	2688	2691	Gene	Gene	response|compound|START_ENTITY enhances|dobj|response enhances|xcomp|END_ENTITY	Reduction of the effects of growth_hormone_release_inhibiting_factor enhances plasma growth_hormone response to GHRH .
2574645	0	growth_hormone	31,45	GHRH	64,68	growth hormone	GHRH	2688	2691	Gene	Gene	responses|amod|START_ENTITY variability|nmod|responses Reasons|nmod|variability Reasons|acl|END_ENTITY	Reasons for the variability in growth_hormone -LRB- GH -RRB- responses to GHRH challenge : the endogenous hypothalamic-somatotroph_rhythm -LRB- HSR -RRB- .
25931044	0	growth_hormone	66,80	GHRH	22,26	growth hormone	GHRH	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY diagnostics|nmod|deficiency test|nmod|diagnostics test|nsubj|usefulness usefulness|nmod|stimulation stimulation|compound|END_ENTITY	The usefulness of the GHRH stimulation test in the diagnostics of growth_hormone deficiency in children .
26059749	0	growth_hormone	41,55	GHRH	111,115	growth hormone	GHRH	2688	2691	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels ratio|acl|circulating ratio|parataxis|isoforms isoforms|nmod|administration administration|compound|END_ENTITY	Unaltered ratio of circulating levels of growth_hormone / GH isoforms in adults with Prader-Willi_syndrome after GHRH plus arginine administration .
2883595	0	growth_hormone	106,120	GHRH	138,142	growth hormone	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	response|amod|START_ENTITY infusions|nmod|response infusions|xcomp|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
2883595	0	growth_hormone	106,120	GHRH	72,76	growth hormone	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	response|amod|START_ENTITY infusions|nmod|response infusions|nsubj|Effect Effect|appos|END_ENTITY	Effect of continuous somatostatin and growth_hormone-releasing_hormone -LRB- GHRH -RRB- infusions on the subsequent growth_hormone -LRB- GH -RRB- response to GHRH .
3096623	0	growth_hormone	96,110	GHRH	77,81	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|amod|START_ENTITY NH2|nmod|secretion NH2|nsubj|effect effect|appos|END_ENTITY	The effect of intravenous , subcutaneous , and intranasal GH-RH analog , -LSB- Nle27 -RSB- GHRH -LRB- 1-29 -RRB- - NH2 , on growth_hormone secretion in normal men : dose-response relationships .
3104015	0	growth_hormone	4,18	GHRH	43,47	growth hormone	GHRH	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	START_ENTITY|dep|hormone hormone|appos|END_ENTITY	The growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- - GH-somatomedin axis : evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II .
3119651	0	growth_hormone	42,56	GHRH	218,222	growth hormone	GHRH	2688	2691	Gene	Gene	hypothalamic_dysfunction|nmod|START_ENTITY Evaluation|nmod|hypothalamic_dysfunction Evaluation|dep|patients patients|acl|using using|advcl|END_ENTITY	Evaluation of hypothalamic_dysfunction in growth_hormone -LRB- GH -RRB- - deficient patients using single versus multiple doses of GH-releasing hormone -LRB- GHRH-44 -RRB- and evidence for diurnal variation in somatotroph responsiveness to GHRH in GH-deficient patients .
7593423	0	growth_hormone	11,25	GHRH	98,102	growth hormone	GHRH	2688	2691	Gene	Gene	Absence|nmod|START_ENTITY secretion|nsubj|Absence secretion|nmod|administration administration|nmod|hormone hormone|appos|END_ENTITY	Absence of growth_hormone -LRB- GH -RRB- secretion after the administration of either GH-releasing hormone -LRB- GHRH -RRB- , GH-releasing peptide -LRB- GHRP-6 -RRB- , or GHRH plus GHRP-6 in children with neonatal pituitary stalk transection .
7932284	0	growth_hormone	96,110	GHRH	34,38	growth hormone	GHRH	2688	2691	Gene	Gene	effects|nmod|START_ENTITY Growth_hormone-releasing_hormone|dep|effects Growth_hormone-releasing_hormone|appos|END_ENTITY	Growth_hormone-releasing_hormone -LRB- GHRH -RRB- - induced effects on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression .
8349808	0	growth_hormone	15,29	GHRH	82,86	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|hormone hormone|appos|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- secretion by a selective GH-releasing hormone -LRB- GHRH -RRB- antagonist .
8421084	0	growth_hormone	10,24	GHRH	49,53	growth hormone	GHRH	2688	2691	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|hormone hormone|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- - releasing hormone -LRB- GHRH -RRB- , atropine , pyridostigmine , or hypoglycemia on GHRP-6-induced GH secretion in man .
8513607	0	growth_hormone	63,77	GHRH	129,133	growth hormone	GHRH	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|stimulation stimulation|appos|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
8588384	0	growth_hormone	91,105	GHRH	45,49	growth hormone	GHRH	2688	2691	Gene	Gene	secretion|nmod|START_ENTITY EEG|dobj|secretion EEG|nsubj|Action Action|nmod|growth_hormone_releasing_hormone growth_hormone_releasing_hormone|appos|END_ENTITY	-LSB- Action of growth_hormone_releasing_hormone -LRB- GHRH -RRB- on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression -RSB- .
8851324	0	growth_hormone	13,27	GHRH	85,89	growth hormone	GHRH	2688	2691	Gene	Gene	Behavior|nmod|START_ENTITY Behavior|appos|END_ENTITY	-LSB- Behavior of growth_hormone after stimulation with growth_hormone_releasing_hormone -LRB- GHRH -RRB- in children with disorders_of_the_hypothalamo-hypophyseal_axis and girls with Turner_syndrome -RSB- .
9024267	0	growth_hormone	15,29	GHRH	108,112	growth hormone	GHRH	2688	2691	Gene	Gene	Suppression|nmod|START_ENTITY hypersecretion|nsubj|Suppression hypersecretion|nmod|antagonist antagonist|compound|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
9024267	0	growth_hormone	15,29	GHRH	87,91	growth hormone	GHRH	2688	2691	Gene	Gene	Suppression|nmod|START_ENTITY hypersecretion|nsubj|Suppression hypersecretion|xcomp|due due|nmod|GH-releasing_hormone GH-releasing_hormone|appos|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- hypersecretion due to ectopic GH-releasing_hormone -LRB- GHRH -RRB- by a selective GHRH antagonist .
7673420	0	growth_hormone	42,56	GH_binding_protein	93,111	growth hormone	GH binding protein	2688	2690	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Acute and chronic effects of subcutaneous growth_hormone -LRB- GH -RRB- injections on plasma levels of GH_binding_protein in short children .
7475906	0	growth_hormone	22,36	GH_receptor	60,71	growth hormone	GH receptor	81668(Tax:10116)	25235(Tax:10116)	Gene	Gene	administration|amod|START_ENTITY administration|nmod|END_ENTITY	Effect of fasting and growth_hormone -LRB- GH -RRB- administration on GH_receptor -LRB- GHR -RRB- messenger ribonucleic acid -LRB- mRNA -RRB- and GH-binding protein -LRB- GHBP -RRB- mRNA levels in male rats .
8894644	0	growth_hormone	62,76	GH_receptor	100,111	growth hormone	GH receptor	443329(Tax:9940)	443333(Tax:9940)	Gene	Gene	administration|amod|START_ENTITY administration|nmod|END_ENTITY	Differential effects of maternal ovine placental_lactogen and growth_hormone -LRB- GH -RRB- administration on GH_receptor , insulin-like_growth_factor _ -LRB- IGF -RRB- -1 and IGF binding protein-3 gene expression in the pregnant and fetal sheep .
1553429	0	growth_hormone	25,39	GH_releasing_hormone	52,72	growth hormone	GH releasing hormone	403795(Tax:9615)	485863(Tax:9615)	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Effect of propranolol on growth_hormone response to GH_releasing_hormone -LRB- GHRH 1-44 -RRB- in the dog .
12397536	0	growth_hormone	10,24	GLP-1	75,80	growth hormone	GLP-1	81668(Tax:10116)	24952(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of growth_hormone on high plasma levels of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in hypophysectomized rats .
11306336	0	growth_hormone	60,74	Ghrelin	0,7	growth hormone	Ghrelin	2688	59301(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY ligand|nmod|receptor endogenous|acl|ligand discovery|nmod|endogenous END_ENTITY|dep|discovery	Ghrelin : discovery of the natural endogenous ligand for the growth_hormone secretagogue receptor .
15363972	0	growth_hormone	110,124	Ghrelin	0,7	growth hormone	Ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY adipocytes|nmod|receptor inhibit|nmod|adipocytes inhibit|nsubj|END_ENTITY	Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth_hormone secretagogue receptor .
15478030	0	growth_hormone	22,36	Ghrelin	0,7	growth hormone	Ghrelin	2688	58991(Tax:10090)	Gene	Gene	secretagogues|compound|START_ENTITY secretagogues|compound|END_ENTITY	Ghrelin and synthetic growth_hormone secretagogues are cardioactive molecules with identities and differences .
17109935	0	growth_hormone	19,33	Ghrelin	0,7	growth hormone	Ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Ghrelin stimulates growth_hormone secretion and food intake in aged rats .
17556866	0	growth_hormone	17,31	Ghrelin	0,7	growth hormone	Ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	responses|amod|START_ENTITY improves|dobj|responses improves|nsubj|END_ENTITY	Ghrelin improves growth_hormone responses to growth_hormone-releasing hormone in a streptozotocin-diabetic model of delayed onset .
1314998	0	growth_hormone	33,47	Growth_hormone	0,14	growth hormone	Growth hormone	2688	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to acute growth_hormone releasing hormone administration in uraemic patients on haemodialysis .
1768809	0	growth_hormone	60,74	Growth_hormone	0,14	growth hormone	Growth hormone	2688	2688	Gene	Gene	use|nmod|START_ENTITY END_ENTITY|dep|use	Growth_hormone and the kidney : the use of recombinant human growth_hormone -LRB- rhGH -RRB- in growth-retarded children with chronic_renal_insufficiency .
8443052	0	growth_hormone	74,88	Growth_hormone	0,14	growth hormone	Growth hormone	2688	2688	Gene	Gene	treatment|dep|START_ENTITY treatment|amod|END_ENTITY	Growth_hormone treatment and development of malignancy : recombinant human growth_hormone does not induce leukemia in AKR/O-mice .
6424119	0	growth_hormone	42,56	Growth_hormone-releasing_factor	0,31	growth hormone	Growth hormone-releasing factor	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY regulates|dobj|mRNA regulates|nsubj|END_ENTITY	Growth_hormone-releasing_factor regulates growth_hormone mRNA in primary cultures of rat pituitary cells .
6436973	0	growth_hormone	51,65	Growth_hormone-releasing_factor	0,31	growth hormone	Growth hormone-releasing factor	2688	2691	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Growth_hormone-releasing_factor : direct effects on growth_hormone , glucose , and behavior via the brain .
10461024	0	growth_hormone	56,70	Growth_hormone-releasing_hormone	0,32	growth hormone	Growth hormone-releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|attenuate attenuate|amod|END_ENTITY	Growth_hormone-releasing_hormone and morphine attenuate growth_hormone secretagogue-induced activation of the arcuate nucleus in the male rat .
11572322	0	growth_hormone	109,123	Growth_hormone-releasing_hormone	0,32	growth hormone	Growth hormone-releasing hormone	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY diagnosis|nmod|deficiency secretagogues|nmod|diagnosis combined|nmod|secretagogues combined|nsubj|END_ENTITY	Growth_hormone-releasing_hormone combined with arginine or growth_hormone secretagogues for the diagnosis of growth_hormone deficiency in adults .
3092819	0	growth_hormone	73,87	Growth_hormone-releasing_hormone	0,32	growth hormone	Growth hormone-releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	biosynthesis|nmod|START_ENTITY stimulate|dobj|biosynthesis END_ENTITY|dep|stimulate	Growth_hormone-releasing_hormone and clonidine stimulate biosynthesis of growth_hormone in neonatal pituitaries .
3096037	0	growth_hormone	67,81	Growth_hormone-releasing_hormone	0,32	growth hormone	Growth hormone-releasing hormone	2688	2691	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Growth_hormone-releasing_hormone in the diagnosis and treatment of growth_hormone deficient children .
3134650	0	growth_hormone	92,106	Growth_hormone-releasing_hormone	0,32	growth hormone	Growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY disorders|nmod|secretion subjects|nmod|disorders studies|nmod|subjects END_ENTITY|dep|studies	Growth_hormone-releasing_hormone : studies in normal subjects and patients with disorders of growth_hormone secretion .
7932284	0	growth_hormone	96,110	Growth_hormone-releasing_hormone	0,32	growth hormone	Growth hormone-releasing hormone	2688	2691	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Growth_hormone-releasing_hormone -LRB- GHRH -RRB- - induced effects on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression .
9238854	0	growth_hormone	103,117	Growth_hormone-releasing_hormone	0,32	growth hormone	Growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY enhance|dobj|secretion END_ENTITY|dep|enhance	Growth_hormone-releasing_hormone and growth_hormone-releasing_peptide as therapeutic agents to enhance growth_hormone secretion in disease and aging .
6130528	0	growth_hormone	66,80	Growth_hormone_releasing_factor	0,31	growth hormone	Growth hormone releasing factor	2688	2691	Gene	Gene	releases|xcomp|START_ENTITY releases|nsubj|END_ENTITY	Growth_hormone_releasing_factor , somatocrinin , releases pituitary growth_hormone in vitro .
2840597	0	growth_hormone	52,66	Growth_hormone_releasing_hormone	0,32	growth hormone	Growth hormone releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Growth_hormone_releasing_hormone induced release of growth_hormone in aging male rats : dependence on pharmacological manipulation and endogenous somatostatin release .
3111168	0	growth_hormone	78,92	Growth_hormone_releasing_hormone	0,32	growth hormone	Growth hormone releasing hormone	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY treatment|nmod|deficiency END_ENTITY|nmod|treatment	Growth_hormone_releasing_hormone in the assessment and long-term treatment of growth_hormone deficiency .
3923425	0	growth_hormone	81,95	Growth_hormone_releasing_hormone	0,32	growth hormone	Growth hormone releasing hormone	2688	2691	Gene	Gene	deficiency|compound|START_ENTITY studies|nmod|deficiency END_ENTITY|dep|studies	Growth_hormone_releasing_hormone and growth_hormone : genetic studies in familial growth_hormone deficiency .
8319372	0	growth_hormone	51,65	Growth_hormone_releasing_hormone	0,32	growth hormone	Growth hormone releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Growth_hormone_releasing_hormone priming increases growth_hormone secretion in patients with Cushing 's _ syndrome .
10082812	0	growth_hormone	59,73	IGF-1	30,35	growth hormone	IGF-1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY inhibition|nmod|secretion Insulin-like_growth_factor-1|dep|inhibition Insulin-like_growth_factor-1|appos|END_ENTITY	Insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- - induced inhibition of growth_hormone secretion is associated with sleep suppression .
10708900	0	growth_hormone	56,70	IGF-1	13,18	growth hormone	IGF-1	2688	3479	Gene	Gene	effects|nmod|START_ENTITY Secretion|dep|effects Secretion|nmod|END_ENTITY	Secretion of IGF-1 by ovine granulosa cells : effects of growth_hormone and follicle stimulating hormone .
11577173	0	growth_hormone	40,54	IGF-1	30,35	growth hormone	IGF-1	2688	3479	Gene	Gene	Insulin-like_growth_factor_1|dep|START_ENTITY Insulin-like_growth_factor_1|appos|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- : a growth_hormone .
12587838	0	growth_hormone	64,78	IGF-1	15,20	growth hormone	IGF-1	2688	3479	Gene	Gene	children|amod|START_ENTITY ELISA|nmod|children Measurement|nmod|ELISA Measurement|nmod|levels levels|amod|END_ENTITY	Measurement of IGF-1 , IGFBP-3 and free IGF-1 levels by ELISA in growth_hormone -LRB- GH -RRB- deficient children before and after GH replacement .
12587838	0	growth_hormone	64,78	IGF-1	39,44	growth hormone	IGF-1	2688	3479	Gene	Gene	children|amod|START_ENTITY ELISA|nmod|children Measurement|nmod|ELISA Measurement|nmod|levels levels|compound|END_ENTITY	Measurement of IGF-1 , IGFBP-3 and free IGF-1 levels by ELISA in growth_hormone -LRB- GH -RRB- deficient children before and after GH replacement .
14514630	0	growth_hormone	174,188	IGF-1	41,46	growth hormone	IGF-1	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY subunit|dep|roles deletion|nmod|subunit abrogated|nmod|deletion abrogated|nsubjpass|resistance resistance|nmod|mouse mouse|compound|END_ENTITY	Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding_protein-3 complex : relative roles of growth_hormone and IGF-1 in insulin resistance .
14535356	0	growth_hormone	42,56	IGF-1	93,98	growth hormone	IGF-1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	prolactin|appos|START_ENTITY prolactin|appos|insulin-like_growth_factor-1 insulin-like_growth_factor-1|appos|END_ENTITY	Daily profiles of plasma prolactin -LRB- PRL -RRB- , growth_hormone -LRB- GH -RRB- , insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- , luteinizing hormone -LRB- LH -RRB- , testosterone , and melatonin , and of pituitary PRL mRNA and GH mRNA in male Long Evans rats in acute phase of adjuvant_arthritis .
17270100	0	growth_hormone	7,21	IGF-1	52,57	growth hormone	IGF-1	2688	3479	Gene	Gene	START_ENTITY|parataxis|sufficient sufficient|nsubj|END_ENTITY	Silent growth_hormone secreting pituitary_adenomas : IGF-1 is not sufficient to exclude growth_hormone excess .
17270100	0	growth_hormone	87,101	IGF-1	52,57	growth hormone	IGF-1	2688	3479	Gene	Gene	excess|amod|START_ENTITY exclude|dobj|excess sufficient|xcomp|exclude sufficient|nsubj|END_ENTITY	Silent growth_hormone secreting pituitary_adenomas : IGF-1 is not sufficient to exclude growth_hormone excess .
17371460	0	growth_hormone	47,61	IGF-1	64,69	growth hormone	IGF-1	2688	3479	Gene	Gene	metabolism|nmod|START_ENTITY Modulation|nmod|metabolism Modulation|dep|axis axis|compound|END_ENTITY	Modulation of glucocorticoid metabolism by the growth_hormone - IGF-1 axis .
17991453	0	growth_hormone	24,38	IGF-1	64,69	growth hormone	IGF-1	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY strategy|nmod|deficiency strategy|dep|relevance relevance|nmod|determination determination|compound|END_ENTITY	Diagnostic strategy for growth_hormone deficiency : relevance of IGF-1 determination as a screening test .
21081804	0	growth_hormone	23,37	IGF-1	40,45	growth hormone	IGF-1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	axis|appos|START_ENTITY Role|nmod|axis Role|dep|END_ENTITY	Role of hormonal axis , growth_hormone - IGF-1 , in the therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis .
21114510	0	growth_hormone	105,119	IGF-1	6,11	growth hormone	IGF-1	2688	3479	Gene	Gene	response|amod|START_ENTITY marker|nmod|response concentrations|nmod|marker concentrations|nsubj|END_ENTITY	Serum IGF-1 concentrations in a sample of patients with traumatic_brain_injury as a diagnostic marker of growth_hormone secretory response to glucagon stimulation testing .
21274301	0	growth_hormone	79,93	IGF-1	23,28	growth hormone	IGF-1	2688	3479	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|END_ENTITY	Combined evaluation of IGF-1 and IGFBP-3 as an index of efficacy and safety in growth_hormone treated patients .
22565153	0	growth_hormone	35,49	IGF-1	77,82	growth hormone	IGF-1	2688	3479	Gene	Gene	regimens|nmod|START_ENTITY Comparison|nmod|regimens Comparison|nmod|levels levels|compound|END_ENTITY	Comparison of two dose regimens of growth_hormone -LRB- GH -RRB- with different target IGF-1 levels on glucose metabolism , lipid profile , cardiovascular function and anthropometric parameters in gh-deficient adults .
23179244	0	growth_hormone	27,41	IGF-1	77,82	growth hormone	IGF-1	2688	3479	Gene	Gene	prediction|nmod|START_ENTITY prediction|parataxis|axis axis|nsubj|insulin-like_growth_factor-1 insulin-like_growth_factor-1|appos|END_ENTITY	Preoperative prediction of growth_hormone -LRB- GH -RRB- / insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- axis modification and postoperative changes in candidates for bariatric surgery .
24955154	0	growth_hormone	99,113	IGF-1	26,31	growth hormone	IGF-1	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY lead|nmod|deficiency lead|nsubj|Correlation Correlation|nmod|END_ENTITY	Correlation between serum IGF-1 and blood lead level in short_stature children and adolescent with growth_hormone deficiency .
25098324	0	growth_hormone	52,66	IGF-1	67,72	growth hormone	IGF-1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	cerebral_ischemia|nmod|START_ENTITY cerebral_ischemia|parataxis|deficient deficient|nsubj|END_ENTITY	Endothelin-1-induced focal cerebral_ischemia in the growth_hormone / IGF-1 deficient Lewis Dwarf rat .
25213432	0	growth_hormone	47,61	IGF-1	26,31	growth hormone	IGF-1	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY value|nmod|deficiency value|nmod|END_ENTITY	Diagnostic value of serum IGF-1 and IGFBP-3 in growth_hormone deficiency : a systematic review with meta-analysis .
25466885	0	growth_hormone	81,95	IGF-1	133,138	growth hormone	IGF-1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	elements|amod|START_ENTITY elements|nmod|gene gene|compound|END_ENTITY	Intrauterine_growth_restriction disrupts developmental epigenetics around distal growth_hormone response elements on the rat hepatic IGF-1 gene .
26487705	0	growth_hormone	67,81	IGF-1	114,119	growth hormone	IGF-1	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	responsive|amod|START_ENTITY element|amod|responsive element|nmod|gene gene|compound|END_ENTITY	Intrauterine_growth_restriction perturbs nucleosome depletion at a growth_hormone responsive element in the mouse IGF-1 gene .
7688379	0	growth_hormone	14,28	IGF-1	172,177	growth hormone	IGF-1	2688	3479	Gene	Gene	treatment|amod|START_ENTITY treatment|dep|changes changes|nmod|insulin-like_growth_factor-1 insulin-like_growth_factor-1|appos|END_ENTITY	Supplementary growth_hormone treatment of women with poor ovarian response to exogenous gonadotrophins : changes in serum and follicular fluid insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- .
7830002	0	growth_hormone	131,145	IGF-1	147,152	growth hormone	IGF-1	403795(Tax:9615)	610255(Tax:9615)	Gene	Gene	insulin|compound|START_ENTITY insulin|dep|END_ENTITY	Effects of acute and repeated intravenous administration of L-692 ,585 , a novel non-peptidyl growth_hormone secretagogue , on plasma growth_hormone , IGF-1 , ACTH , cortisol , prolactin , insulin , and thyroxine levels in beagles .
8315259	0	growth_hormone	8,22	IGF-1	80,85	growth hormone	IGF-1	2688	3479	Gene	Gene	excretion|amod|START_ENTITY excretion|appos|END_ENTITY	Urinary growth_hormone -LRB- U-GH -RRB- excretion and serum insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in patients with alcoholic_cirrhosis .
8657365	0	growth_hormone	45,59	IGF-1	0,5	growth hormone	IGF-1	2688	3479	Gene	Gene	secretion|amod|START_ENTITY screening|nmod|secretion screening|compound|END_ENTITY	IGF-1 and IGFBP-3 screening for disorders of growth_hormone secretion .
8887152	0	growth_hormone	55,69	IGF-1	22,27	growth hormone	IGF-1	2688	3479	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Short stature and low IGF-1 and IGFBP-3 despite normal growth_hormone secretion in a 4 year-old girl with primary empty_sella syndrome .
8887900	0	growth_hormone	11,25	IGF-1	60,65	growth hormone	IGF-1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	treatments|amod|START_ENTITY treatments|appos|END_ENTITY	Effects of growth_hormone and insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- treatments on the nitrogen metabolism and hepatic IGF-1-messenger RNA expression in postoperative parenterally fed rats .
8995736	0	growth_hormone	44,58	IGF-1	59,64	growth hormone	IGF-1	2688	3479	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|axis axis|compound|END_ENTITY	Effect of chronic metabolic_acidosis on the growth_hormone / IGF-1 endocrine axis : new cause of growth_hormone insensitivity in humans .
8995736	0	growth_hormone	94,108	IGF-1	59,64	growth hormone	IGF-1	2688	3479	Gene	Gene	insensitivity|amod|START_ENTITY cause|nmod|insensitivity axis|dep|cause axis|compound|END_ENTITY	Effect of chronic metabolic_acidosis on the growth_hormone / IGF-1 endocrine axis : new cause of growth_hormone insensitivity in humans .
9667397	0	growth_hormone	86,100	IGF-1	16,21	growth hormone	IGF-1	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY diagnosis|nmod|deficiency parameters|nmod|diagnosis END_ENTITY|nmod|parameters	Arm span , serum IGF-1 and IGFBP-3 levels as screening parameters for the diagnosis of growth_hormone deficiency in patients with myelomeningocele -- preliminary data .
10102080	0	growth_hormone	119,133	IGF-I	55,60	growth hormone	IGF-I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY predict|nmod|therapy predict|nsubj|increments increments|nmod|I I|appos|END_ENTITY	Short-term increments of insulin-like growth factor I -LRB- IGF-I -RRB- and IGF-binding_protein-3 predict the growth response to growth_hormone -LRB- GH -RRB- therapy in GH-sensitive children .
10208950	0	growth_hormone	41,55	IGF-I	11,16	growth hormone	IGF-I	2688	3479	Gene	Gene	insufficiency|amod|START_ENTITY diagnose|dobj|insufficiency Failure|acl|diagnose Failure|nmod|END_ENTITY	Failure of IGF-I and IGFBP-3 to diagnose growth_hormone insufficiency .
10435854	0	growth_hormone	35,49	IGF-I	7,12	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY marker|nmod|deficiency marker|nsubj|END_ENTITY	Plasma IGF-I is a useful marker of growth_hormone deficiency in adults .
10469014	0	growth_hormone	65,79	IGF-I	6,11	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY predict|dobj|deficiency predict|nsubj|END_ENTITY	Serum IGF-I and IGFBP-3 concentrations do not accurately predict growth_hormone deficiency in children with brain_tumours .
10502457	0	growth_hormone	28,42	IGF-I	91,96	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|dep|induction induction|nmod|mRNA mRNA|appos|END_ENTITY	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
10668288	0	growth_hormone	128,142	IGF-I	62,67	growth hormone	IGF-I	2688	3479	Gene	Gene	_|amod|START_ENTITY diagnosis|nmod|_ Usefulness|nmod|diagnosis Usefulness|nmod|measurement measurement|nmod|insulin-like_growth_factor insulin-like_growth_factor|appos|END_ENTITY	-LSB- Usefulness of the measurement of insulin-like_growth_factor -LRB- IGF-I -RRB- and IGF-1_binding_protein-3 -LRB- IGFBP-3 -RRB- for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in children -RSB- .
10828837	0	growth_hormone	97,111	IGF-I	0,5	growth hormone	IGF-I	2688	24482(Tax:10116)	Gene	Gene	given|dobj|START_ENTITY given|nsubj|proteins proteins|compound|END_ENTITY	IGF-I and IGF-I-binding proteins in rats with adjuvant-induced arthritis given recombinant human growth_hormone .
10844596	0	growth_hormone	36,50	IGF-I	51,56	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	metabolic_acidosis|nmod|START_ENTITY Effect|nmod|metabolic_acidosis Effect|dep|axis axis|amod|END_ENTITY	Effect of metabolic_acidosis on the growth_hormone / IGF-I endocrine axis in skeletal growth centers .
10863894	0	growth_hormone	48,62	IGF-I	26,31	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY Measurement|nmod|deficiency Measurement|nmod|END_ENTITY	Measurement of serum free IGF-I in diagnosis of growth_hormone deficiency .
10890180	0	growth_hormone	13,27	IGF-I	79,84	growth hormone	IGF-I	14599(Tax:10090)	3479	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|xcomp|expression expression|nsubj|factor-I factor-I|appos|END_ENTITY	20 kDa human growth_hormone -LRB- 20K hGH -RRB- stimulates insulin-like growth factor-I -LRB- IGF-I -RRB- gene expression at lower concentrations than 22K hGH in hGH_receptor-expressing Ba/F3 cells .
10985758	0	growth_hormone	29,43	IGF-I	77,82	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY prevent|nsubj|administration prevent|dobj|decrease decrease|nmod|expression expression|amod|END_ENTITY	Continuous administration of growth_hormone does not prevent the decrease of IGF-I gene expression in zinc-deprived rats despite normalization of liver GH binding .
11181253	0	growth_hormone	70,84	IGF-I	20,25	growth hormone	IGF-I	2688	3479	Gene	Gene	insufficiency|amod|START_ENTITY diagnosis|nmod|insufficiency GH|nmod|diagnosis GH|nsubj|sensitivity sensitivity|nmod|END_ENTITY	-LSB- Low sensitivity of IGF-I , IGFBP-3 and urinary GH in the diagnosis of growth_hormone insufficiency in slowly-growing short-statured boys .
11466586	0	growth_hormone	34,48	IGF-I	10,15	growth hormone	IGF-I	2688	3479	Gene	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|administration administration|amod|END_ENTITY	Effect of IGF-I administration on growth_hormone secretion in obese subjects .
11847474	0	growth_hormone	47,61	IGF-I	26,31	growth hormone	IGF-I	2688	3479	Gene	Gene	disorders|amod|START_ENTITY value|nmod|disorders value|nmod|END_ENTITY	Diagnostic value of serum IGF-I and IGFBP-3 in growth_hormone disorders in adults .
12201823	0	growth_hormone	23,37	IGF-I	121,126	growth hormone	IGF-I	2688	3479	Gene	Gene	sensitivity|amod|START_ENTITY markers|nmod|sensitivity markers|dep|capacity capacity|nmod|generation generation|amod|END_ENTITY	Biochemical markers of growth_hormone -LRB- GH -RRB- sensitivity in children with idiopathic_short_stature : individual capacity of IGF-I generation after high-dose GH treatment determines the growth response to GH .
12409314	0	growth_hormone	106,120	IGF-I	126,131	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY separates|dobj|effects separates|dep|excess excess|amod|END_ENTITY	Insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- separates hypertrophic and hyperplastic effects of growth_hormone -LRB- GH -RRB- / IGF-I excess on adrenocortical cells in vivo .
12478375	0	growth_hormone	159,173	IGF-I	174,179	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY not|nmod|absence size|dep|not END_ENTITY|nsubj|size	Insulin-like_growth_factor-binding_protein-2 -LRB- IGFBP-2 -RRB- overexpression negatively regulates bone size and mass , but not density , in the absence and presence of growth_hormone / IGF-I excess in transgenic_mice .
12763169	0	growth_hormone	22,36	IGF-I	71,76	growth hormone	IGF-I	2688	3479	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Synergistic action of growth_hormone and insulin-like_growth_factor_I -LRB- IGF-I -RRB- on proliferation and estradiol secretion in porcine granulosa and theca cells cultured alone or in coculture .
12906369	0	growth_hormone	42,56	IGF-I	93,98	growth hormone	IGF-I	2688	3479	Gene	Gene	injections|nmod|START_ENTITY restore|nsubj|injections restore|xcomp|circulating circulating|dobj|concentrations concentrations|amod|END_ENTITY	Three weekly injections -LRB- TWI -RRB- of low-dose growth_hormone -LRB- GH -RRB- restore low normal circulating IGF-I concentrations and reverse cardiac_abnormalities associated with adult_onset GH_deficiency -LRB- GHD -RRB- .
12944101	0	growth_hormone	48,62	IGF-I	124,129	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|xcomp|signaling signaling|nmod|hepatocytes hepatocytes|dep|explanation explanation|nmod|impact impact|nmod|END_ENTITY	Estrogen agonists/antagonists may down-regulate growth_hormone signaling in hepatocytes -- an explanation for their impact on IGF-I , IGFBP-1 , and lipoprotein -LRB- a -RRB- .
1306846	0	growth_hormone	10,24	IGF-I	36,41	growth hormone	IGF-I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Effect of growth_hormone therapy on IGF-I , bone_GLA-protein and bone mineral content in short children with and without chronic_renal_failure .
14565994	0	growth_hormone	32,46	IGF-I	74,79	growth hormone	IGF-I	2688	3479	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of recombinant human growth_hormone and resistance training on IGF-I mRNA expression in the muscles of elderly men .
14714750	0	growth_hormone	126,140	IGF-I	49,54	growth hormone	IGF-I	2688	3479	Gene	Gene	level|nmod|START_ENTITY presenting|nmod|level growth_disorders|acl|presenting Analysis|nmod|growth_disorders Analysis|nmod|gene gene|amod|END_ENTITY	Analysis of coding and promoter sequences of the IGF-I gene in children with growth_disorders presenting with normal level of growth_hormone .
14960017	0	growth_hormone	31,45	IGF-I	77,82	growth hormone	IGF-I	2688	3479	Gene	Gene	levels|nmod|START_ENTITY levels|appos|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Basal and stimulated levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-I binding and IGF-binding proteins in beta-thalassemia major .
14960017	0	growth_hormone	31,45	IGF-I	85,90	growth hormone	IGF-I	2688	3479	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nsubj|levels	Basal and stimulated levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-I binding and IGF-binding proteins in beta-thalassemia major .
14997011	0	growth_hormone	130,144	IGF-I	50,55	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	exogenous|amod|START_ENTITY binding|nmod|exogenous binding|nsubj|Modulation Modulation|appos|END_ENTITY	Modulation of brain insulin-like_growth_factor_I -LRB- IGF-I -RRB- binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth_hormone and IGF-I in juvenile rats .
15125887	0	growth_hormone	30,44	IGF-I	8,13	growth hormone	IGF-I	2688	3479	Gene	Gene	myocardial_infarction|amod|START_ENTITY END_ENTITY|nmod|myocardial_infarction	Cardiac IGF-I manipulation by growth_hormone following myocardial_infarction .
15270408	0	growth_hormone	21,35	IGF-I	82,87	growth hormone	IGF-I	2688	3479	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|dep|GH GH|dep|components components|appos|END_ENTITY	Alterations in serum growth_hormone -LRB- GH -RRB- / GH dependent ternary complex components -LRB- IGF-I , IGFBP-3 , ALS , IGF-I/IGFBP -3 molar ratio -RRB- and the influence of these alterations on growth pattern in female rhythmic gymnasts .
15583470	0	growth_hormone	88,102	IGF-I	30,35	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY markers|nmod|deficiency Insulin-like_growth_factor_I|nmod|markers Insulin-like_growth_factor_I|dep|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein_3 as diagnostic markers of growth_hormone deficiency in infancy .
15684342	0	growth_hormone	42,56	IGF-I	95,100	growth hormone	IGF-I	378781(Tax:9031)	100327329(Tax:9031)	Gene	Gene	effect|nmod|START_ENTITY modulate|dobj|effect modulate|advcl|insulin-like_growth_factor-I insulin-like_growth_factor-I|dobj|level level|appos|END_ENTITY	Metabolic hormones modulate the effect of growth_hormone -LRB- GH -RRB- on insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA level in primary culture of salmon hepatocytes .
16039893	0	growth_hormone	53,67	IGF-I	30,35	growth hormone	IGF-I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY Insulin-like_growth_factor_I|nmod|therapy Insulin-like_growth_factor_I|dobj|measurements measurements|appos|END_ENTITY	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- measurements in growth_hormone -LRB- GH -RRB- therapy of idiopathic_short_stature -LRB- ISS -RRB- .
16294267	0	growth_hormone	15,29	IGF-I	109,114	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	estradiol|amod|START_ENTITY Growth|nmod|estradiol regulator|nsubj|Growth regulator|nmod|synthesis synthesis|amod|END_ENTITY	Growth without growth_hormone receptor : estradiol is a major growth_hormone-independent regulator of hepatic IGF-I synthesis .
1658632	0	growth_hormone	52,66	IGF-I	30,35	growth hormone	IGF-I	2688	3479	Gene	Gene	attenuation|nmod|START_ENTITY attenuation|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- attenuation of growth_hormone is enhanced by overexpression of pituitary IGF-I_receptors .
16862465	0	growth_hormone	170,184	IGF-I	59,64	growth hormone	IGF-I	2688	3479	Gene	Gene	_|amod|START_ENTITY patients|nmod|_ changes|nmod|patients changes|nmod|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Pregnancy-induced changes in insulin-like_growth_factor_I -LRB- IGF-I -RRB- , insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- , and acid-labile_subunit -LRB- ALS -RRB- in patients with growth_hormone _ -LRB- GH -RRB- _ deficiency and excess .
16908209	0	growth_hormone	112,126	IGF-I	23,28	growth hormone	IGF-I	2688	3479	Gene	Gene	therapy|compound|START_ENTITY months|nmod|therapy test|nmod|months test|nsubj|correlation correlation|nmod|IGFBP-3 IGFBP-3|compound|END_ENTITY	The correlation of the IGF-I , IGFBP-3 , and ALS generation test to height velocity after 6 months of recombinant growth_hormone therapy in girls with Turner_syndrome .
1710624	0	growth_hormone	31,45	IGF-I	101,106	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Short and long term effects of growth_hormone on circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-1 , and insulin : a placebo-controlled study .
1721016	0	growth_hormone	62,76	IGF-I	7,12	growth hormone	IGF-I	443329(Tax:9940)	443318(Tax:9940)	Gene	Gene	treatment|compound|START_ENTITY effect|nmod|treatment proteins|dep|effect proteins|amod|END_ENTITY	Plasma IGF-I binding proteins in sheep : effect of recombinant growth_hormone treatment and nutritional status .
18167466	0	growth_hormone	68,82	IGF-I	84,89	growth hormone	IGF-I	2688	3479	Gene	Gene	determination|nmod|START_ENTITY Indications|nmod|determination Indications|appos|END_ENTITY	Indications , limitations and pitfalls in the determination of human growth_hormone , IGF-I and their binding proteins .
18647804	0	growth_hormone	108,122	IGF-I	49,54	growth hormone	IGF-I	2688	3479	Gene	Gene	secretion|compound|START_ENTITY mediate|nmod|secretion mediate|dobj|preservation preservation|nmod|levels levels|amod|END_ENTITY	Androgens may mediate a relative preservation of IGF-I levels in overweight and obese women despite reduced growth_hormone secretion .
1885393	0	growth_hormone	70,84	IGF-I	95,100	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY enhances|dobj|effect enhances|nmod|concentrations concentrations|compound|END_ENTITY	Cortisone arrests growth but enhances the inductive effect of porcine growth_hormone on plasma IGF-I concentrations in female rats .
19055455	0	growth_hormone	129,143	IGF-I	58,63	growth hormone	IGF-I	2688	3479	Gene	Gene	IGF-I|nmod|START_ENTITY assays|nmod|IGF-I assays|nsubj|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Five commercially available insulin-like_growth_factor_I -LRB- IGF-I -RRB- assays in comparison to the former Nichols Advantage IGF-I in a growth_hormone treated population .
19083250	0	growth_hormone	22,36	IGF-I	47,52	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	circulating|dobj|START_ENTITY Effect|acl|circulating END_ENTITY|nsubj|Effect	Effect of circulating growth_hormone on muscle IGF-I protein concentration in female mice with growth_hormone receptor gene disruption .
19083250	0	growth_hormone	95,109	IGF-I	47,52	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	disruption|amod|START_ENTITY END_ENTITY|nmod|disruption	Effect of circulating growth_hormone on muscle IGF-I protein concentration in female mice with growth_hormone receptor gene disruption .
19570739	0	growth_hormone	76,90	IGF-I	34,39	growth hormone	IGF-I	2688	3479	Gene	Gene	status|amod|START_ENTITY indicator|nmod|status test|nmod|indicator test|nsubj|generation generation|compound|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- generation test as an indicator of growth_hormone status .
19571554	0	growth_hormone	22,36	IGF-I	4,9	growth hormone	IGF-I	2688	3479	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	The IGF-I response to growth_hormone is related to body mass index in short children with normal weight .
19916171	0	growth_hormone	10,24	IGF-I	88,93	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY homeostasis|nsubj|Effect homeostasis|nmod|mediators mediators|amod|END_ENTITY	Effect of growth_hormone on small intestinal homeostasis relation to cellular mediators IGF-I and IGFBP-3 .
2013221	0	growth_hormone	68,82	IGF-I	47,52	growth hormone	IGF-I	443329(Tax:9940)	443318(Tax:9940)	Gene	Gene	concentrations|amod|START_ENTITY circulating|dobj|concentrations Effect|acl|circulating Effect|nmod|END_ENTITY	Effect of intracerebroventricular injection of IGF-I on circulating growth_hormone concentrations in the sheep .
20190537	0	growth_hormone	141,155	IGF-I	91,96	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency serum|nmod|patients serum|dobj|levels levels|amod|END_ENTITY	Genetic polymorphisms in the locus control region and promoter of GH1 are related to serum IGF-I levels and height in patients with isolated growth_hormone deficiency and healthy controls .
2058394	0	growth_hormone	120,134	IGF-I	55,60	growth hormone	IGF-I	2688	3479	Gene	Gene	/|nmod|START_ENTITY /|dobj|axis axis|amod|END_ENTITY	Noonan 's _ syndrome : abnormalities of the growth_hormone / IGF-I axis and the response to treatment with human biosynthetic growth_hormone .
2058394	0	growth_hormone	40,54	IGF-I	55,60	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|acl|/ /|dobj|axis axis|amod|END_ENTITY	Noonan 's _ syndrome : abnormalities of the growth_hormone / IGF-I axis and the response to treatment with human biosynthetic growth_hormone .
20733585	0	growth_hormone	4,18	IGF-I	20,25	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|dep|axis axis|amod|END_ENTITY	The growth_hormone -- IGF-I axis as a mediator for the association between FTO variants and body mass index : results of the Study of Health in Pomerania .
20890664	0	growth_hormone	49,63	IGF-I	16,21	growth hormone	IGF-I	2688	3479	Gene	Gene	hyperplasia|amod|START_ENTITY prevents|dobj|hyperplasia prevents|nsubj|Pasireotide Pasireotide|appos|inhibitor inhibitor|amod|END_ENTITY	Pasireotide , an IGF-I action inhibitor , prevents growth_hormone and estradiol-induced mammary hyperplasia .
21232100	0	growth_hormone	39,53	IGF-I	3,8	growth hormone	IGF-I	2688	3479	Gene	Gene	action|amod|START_ENTITY reflect|dobj|action reflect|nsubj|concentrations concentrations|amod|END_ENTITY	Do IGF-I concentrations better reflect growth_hormone -LRB- GH -RRB- action in children with short_stature than the results of GH stimulating tests ?
21367928	0	growth_hormone	139,153	IGF-I	71,76	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY adults|nmod|deficiency bone_mineral_density|nmod|adults associated|nmod|bone_mineral_density associated|nsubjpass|END_ENTITY	Unreplaced sex steroid_deficiency , corticotropin_deficiency , and lower IGF-I are associated with lower bone_mineral_density in adults with growth_hormone deficiency : a KIMS database analysis .
21714461	0	growth_hormone	44,58	IGF-I	4,9	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY diagnosing|dobj|deficiency useful|advcl|diagnosing useful|nsubj|END_ENTITY	Are IGF-I and IGF-BP3 useful for diagnosing growth_hormone deficiency in children of short_stature ?
21971154	0	growth_hormone	66,80	IGF-I	6,11	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY marker|nmod|activity marker|nsubj|END_ENTITY	Serum IGF-I is not a reliable pharmacodynamic marker of exogenous growth_hormone activity in mice .
21975122	0	growth_hormone	84,98	IGF-I	122,127	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|nmod|test test|compound|END_ENTITY	Transcriptional response of peripheral blood mononuclear cells to recombinant human growth_hormone in a routine four-days IGF-I generation test .
22924571	0	growth_hormone	22,36	IGF-I	109,114	growth hormone	IGF-I	2688	3479	Gene	Gene	Efficacy|nmod|START_ENTITY short_stature|nsubj|Efficacy short_stature|ccomp|related related|nsubjpass|children children|nmod|END_ENTITY	Efficacy of IGF-based growth_hormone -LRB- GH -RRB- dosing in nonGH-deficient -LRB- nonGHD -RRB- short_stature children with low IGF-I is not related to basal IGF-I levels .
22924571	0	growth_hormone	22,36	IGF-I	139,144	growth hormone	IGF-I	2688	3479	Gene	Gene	Efficacy|nmod|START_ENTITY short_stature|nsubj|Efficacy short_stature|ccomp|related related|xcomp|basal basal|dobj|levels levels|amod|END_ENTITY	Efficacy of IGF-based growth_hormone -LRB- GH -RRB- dosing in nonGH-deficient -LRB- nonGHD -RRB- short_stature children with low IGF-I is not related to basal IGF-I levels .
2360624	0	growth_hormone	10,24	IGF-I	62,67	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Placental growth_hormone as a potential regulator of maternal IGF-I during human pregnancy .
23685421	0	growth_hormone	126,140	IGF-I	24,29	growth hormone	IGF-I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY predicts|nmod|therapy predicts|nsubj|increase increase|nmod|ratio ratio|compound|END_ENTITY	Significant increase of IGF-I concentration and of IGF-I/IGFBP -3 molar ratio in generation test predicts the good response to growth_hormone -LRB- GH -RRB- therapy in children with short_stature and normal results of GH stimulating tests .
25239917	0	growth_hormone	81,95	IGF-I	20,25	growth hormone	IGF-I	100356068(Tax:9986)	100008668(Tax:9986)	Gene	Gene	agonists|compound|START_ENTITY bioactivity|nmod|agonists monitor|dobj|bioactivity biomarker|acl|monitor END_ENTITY|nmod|biomarker	Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth_hormone agonists and antagonists in rabbits .
26774404	0	growth_hormone	112,126	IGF-I	33,38	growth hormone	IGF-I	2688	3479	Gene	Gene	skeletal|nmod|START_ENTITY skeletal|dobj|END_ENTITY	FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth_hormone .
3523759	0	growth_hormone	14,28	IGF-I	66,71	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|chondrocytes chondrocytes|acl|containing containing|dobj|END_ENTITY	Regulation by growth_hormone of number of chondrocytes containing IGF-I in rat growth plate .
7508193	0	growth_hormone	10,24	IGF-I	85,90	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	administration|amod|START_ENTITY Effect|nmod|administration exercise|nsubj|Effect exercise|nmod|END_ENTITY	Effect of growth_hormone administration and treadmill exercise on serum and skeletal IGF-I in rats .
7510769	0	growth_hormone	11,25	IGF-I	74,79	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|acl|rat rat|dobj|synthesis synthesis|amod|growth_hormone growth_hormone|nmod|END_ENTITY	Effects of growth_hormone and an antiserum to rat growth_hormone on serum IGF-I and muscle protein synthesis and accretion in the rat .
7513345	0	growth_hormone	10,24	IGF-I	75,80	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|nmod|steroidogenesis steroidogenesis|appos|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Effect of growth_hormone on steroidogenesis , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-1 production and DNA synthesis in cultured human luteinized granulosa cells .
7524925	0	growth_hormone	124,138	IGF-I	49,54	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY diagnosis|nmod|deficiency measurement|nmod|diagnosis measurement|nsubj|Comparison Comparison|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7649526	0	growth_hormone	10,24	IGF-I	28,33	growth hormone	IGF-I	2688	3479	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|amod|END_ENTITY	Effect of growth_hormone on IGF-I levels in a patient with growth_hormone deficiency and Wilson_disease .
7649526	0	growth_hormone	59,73	IGF-I	28,33	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY patient|nmod|deficiency Effect|nmod|patient Effect|nmod|levels levels|amod|END_ENTITY	Effect of growth_hormone on IGF-I levels in a patient with growth_hormone deficiency and Wilson_disease .
7978354	0	growth_hormone	23,37	IGF-I	97,102	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein expression|appos|END_ENTITY	Prenatal expression of growth_hormone receptor/binding protein and insulin-like growth factor-I -LRB- IGF-I -RRB- in the enamel organ .
8053796	0	growth_hormone	6,20	IGF-I	37,42	growth hormone	IGF-I	2688	3479	Gene	Gene	effect|compound|START_ENTITY effect|nmod|END_ENTITY	Human growth_hormone effect on serum IGF-I and muscle function in poliomyelitis survivors .
8062113	0	growth_hormone	7,21	IGF-I	56,61	growth hormone	IGF-I	2688	3479	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Plasma growth_hormone and insulin-like growth factor-I -LRB- IGF-I -RRB- concentrations at the onset of lay in ad libitum and restricted broiler breeder fowl .
8462477	0	growth_hormone	161,175	IGF-I	121,126	growth hormone	IGF-I	443329(Tax:9940)	443318(Tax:9940)	Gene	Gene	status|amod|START_ENTITY END_ENTITY|nmod|status	Differential regulation of transcription initiation from insulin-like_growth_factor-I -LRB- IGF-I -RRB- leader exons and of tissue IGF-I expression in response to changed growth_hormone and nutritional status in sheep .
8531260	0	growth_hormone	12,26	IGF-I	63,68	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|appos|factor-I factor-I|appos|END_ENTITY	Circulating growth_hormone -LRB- GH -RRB- , insulin-like growth factor-I -LRB- IGF-I -RRB- and free thyroxine , GH response to clonidine provocation and CT scanning of the hypothalamic-pituitary area in children with sickle_cell_disease .
8567577	0	growth_hormone	46,60	IGF-I	13,18	growth hormone	IGF-I	2688	3479	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|Responses Responses|nmod|END_ENTITY	Responses of IGF-I to endogenous increases in growth_hormone after heavy-resistance exercise .
8632230	0	growth_hormone	75,89	IGF-I	140,145	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	abolishes|nmod|START_ENTITY abolishes|dobj|concentrations concentrations|appos|END_ENTITY	Moderate food restriction abolishes the pregnancy-associated rise in serum growth_hormone and decreases serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations without altering IGF-I mRNA expression in rats .
8632230	0	growth_hormone	75,89	IGF-I	179,184	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	abolishes|nmod|START_ENTITY abolishes|advcl|altering altering|dobj|expression expression|amod|END_ENTITY	Moderate food restriction abolishes the pregnancy-associated rise in serum growth_hormone and decreases serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations without altering IGF-I mRNA expression in rats .
8674840	0	growth_hormone	28,42	IGF-I	97,102	growth hormone	IGF-I	378781(Tax:9031)	100327329(Tax:9031)	Gene	Gene	administration|amod|START_ENTITY administration|nmod|factor-I factor-I|appos|END_ENTITY	Effect of exogenous chicken growth_hormone -LRB- cGH -RRB- administration on insulin-like growth factor-I -LRB- IGF-I -RRB- gene expression in domestic fowl .
8690108	0	growth_hormone	132,146	IGF-I	111,116	growth hormone	IGF-I	2688	3479	Gene	Gene	action|amod|START_ENTITY mediator|nmod|action END_ENTITY|nmod|mediator	Insulin-like_growth_factor _ -LRB- IGF -RRB- - I and IGF-II stimulate progesterone production by human luteal cells : role of IGF-I as mediator of growth_hormone action .
8816035	0	growth_hormone	19,33	IGF-I	107,112	growth hormone	IGF-I	2688	3479	Gene	Gene	response|amod|START_ENTITY response|dep|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
8832140	0	growth_hormone	41,55	IGF-I	108,113	growth hormone	IGF-I	2688	3479	Gene	Gene	START_ENTITY|nmod|factor-I factor-I|appos|END_ENTITY	Effects of low dose of recombinant human growth_hormone on renal_excretion_of_insulin-like_growth factor-I -LRB- IGF-I -RRB- in humans : an inverse relation between serum and urinary IGF-I level .
8832140	0	growth_hormone	41,55	IGF-I	172,177	growth hormone	IGF-I	2688	3479	Gene	Gene	dose|nmod|START_ENTITY Effects|nmod|dose Effects|dep|relation relation|nmod|level level|compound|END_ENTITY	Effects of low dose of recombinant human growth_hormone on renal_excretion_of_insulin-like_growth factor-I -LRB- IGF-I -RRB- in humans : an inverse relation between serum and urinary IGF-I level .
8875138	0	growth_hormone	21,35	IGF-I	81,86	growth hormone	IGF-I	2688	3479	Gene	Gene	secretion|nmod|START_ENTITY secretion|dep|II II|appos|END_ENTITY	24-hour secretion of growth_hormone -LRB- GH -RRB- , insulin-like_growth_factors-I_and _ - II -LRB- IGF-I , - II -RRB- , prolactin -LRB- PRL -RRB- and thyrotropin -LRB- TSH -RRB- in young adults of normal and tall stature .
8989263	0	growth_hormone	146,160	IGF-I	36,41	growth hormone	IGF-I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY IGF-binding_protein-1_and|nmod|therapy IGF-binding_protein-1_and|nsubj|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-1_and _ -3 , and the acid-labile_subunit as serum markers of body composition during growth_hormone -LRB- GH -RRB- therapy in adults with GH_deficiency .
9041052	0	growth_hormone	163,177	IGF-I	107,112	growth hormone	IGF-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY adults|nmod|deficiency alkaline|nmod|adults alkaline|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like_growth_factor-I -LRB- IGF-I -RRB- and during growth_hormone therapy in adults with growth_hormone deficiency .
9078817	0	growth_hormone	68,82	IGF-I	30,35	growth hormone	IGF-I	2688	3479	Gene	Gene	_|amod|START_ENTITY diagnosis|nmod|_ screening|nmod|diagnosis screening|appos|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- screening for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency .
9225125	0	growth_hormone	26,40	IGF-I	149,154	growth hormone	IGF-I	378781(Tax:9031)	100327329(Tax:9031)	Gene	Gene	administration|nmod|START_ENTITY exerts|nsubj|administration exerts|advcl|circulating circulating|dobj|concentrations concentrations|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Chronic administration of growth_hormone -LRB- GH -RRB- to adult chickens exerts marked effects on circulating concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF binding proteins , hepatic GH regulated gene I , and hepatic GH_receptor mRNA .
9272424	0	growth_hormone	14,28	IGF-I	51,56	growth hormone	IGF-I	2688	3479	Gene	Gene	levels|amod|START_ENTITY changes|nmod|levels correlate|nsubj|changes correlate|nmod|levels levels|amod|END_ENTITY	Do changes in growth_hormone levels correlate with IGF-I levels in patients undergoing IVF-ET ?
9284715	0	growth_hormone	19,33	IGF-I	96,101	growth hormone	IGF-I	2688	3479	Gene	Gene	treatment|compound|START_ENTITY response|nmod|treatment relates|nsubj|response relates|xcomp|serum serum|dobj|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Growth response to growth_hormone -LRB- GH -RRB- treatment relates to serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 in short children with various GH secretion capacities .
9555872	0	growth_hormone	74,88	IGF-I	119,124	growth hormone	IGF-I	2688	3479	Gene	Gene	/|amod|START_ENTITY insulin-like_growth_factor-I|amod|/ insulin-like_growth_factor-I|appos|END_ENTITY	Alcohol withdrawal-induced change in lipoprotein -LRB- a -RRB- : association with the growth_hormone / insulin-like_growth_factor-I -LRB- IGF-I -RRB- / IGF-binding_protein-1 -LRB- IGFBP-1 -RRB- axis .
9568461	0	growth_hormone	112,126	IGF-I	15,20	growth hormone	IGF-I	2688	3479	Gene	Gene	osteoblasts|nmod|START_ENTITY effects|nmod|osteoblasts effects|nmod|END_ENTITY	The effects of IGF-I and IGF-II on proliferation and differentiation of human osteoblasts and interactions with growth_hormone .
9655774	0	growth_hormone	13,27	IGF-I	0,5	growth hormone	IGF-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|and/or and/or|compound|END_ENTITY	IGF-I and/or growth_hormone preserve diaphragm fiber size with moderate malnutrition .
9661598	0	growth_hormone	151,165	IGF-I	69,74	growth hormone	IGF-I	2688	3479	Gene	Gene	status|amod|START_ENTITY evaluation|nmod|status assay|nmod|evaluation assay|nmod|insulin-like_growth_factor_I insulin-like_growth_factor_I|appos|END_ENTITY	Filter paper blood spot assay of human insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 and preliminary application in the evaluation of growth_hormone status .
9701698	0	growth_hormone	34,48	IGF-I	104,109	growth hormone	IGF-I	2688	3479	Gene	Gene	insensitivity_syndrome|amod|START_ENTITY children|nmod|insensitivity_syndrome status|nmod|children status|nmod|END_ENTITY	Metabolic status of children with growth_hormone insensitivity_syndrome and responses to treatment with IGF-I .
9849819	0	growth_hormone	24,38	IGF-I	42,47	growth hormone	IGF-I	2688	3479	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|levels levels|amod|END_ENTITY	Dose-related effects of growth_hormone on IGF-I and IGF-binding_protein-3 levels in non-islet_cell_tumour_hypoglycaemia .
9859217	0	growth_hormone	18,32	IGF-I	63,68	growth hormone	IGF-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY affects|nsubj|Overexpression affects|dobj|expression expression|amod|END_ENTITY	Overexpression of growth_hormone affects alternatively spliced IGF-I mRNA expression in oMt1a-oGH transgenic_mice .
12688134	0	growth_hormone	41,55	IGF-I_binding_protein_3	69,92	growth hormone	IGF-I binding protein 3	2688	3486	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Effect of various doses of biosynthetic growth_hormone on levels of IGF-I_binding_protein_3 -LRB- IGFBP-3 -RRB- in patients with hypopituitarism and growth_hormone deficiency -RSB- .
10668288	0	growth_hormone	128,142	IGFBP-3	98,105	growth hormone	IGFBP-3	2688	3486	Gene	Gene	_|amod|START_ENTITY diagnosis|nmod|_ Usefulness|nmod|diagnosis Usefulness|nmod|measurement measurement|nmod|insulin-like_growth_factor insulin-like_growth_factor|appos|END_ENTITY	-LSB- Usefulness of the measurement of insulin-like_growth_factor -LRB- IGF-I -RRB- and IGF-1_binding_protein-3 -LRB- IGFBP-3 -RRB- for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency in children -RSB- .
7524925	0	growth_hormone	124,138	IGFBP-3	83,90	growth hormone	IGFBP-3	2688	3486	Gene	Gene	deficiency|amod|START_ENTITY diagnosis|nmod|deficiency measurement|nmod|diagnosis measurement|nsubj|Comparison Comparison|nmod|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7688379	0	growth_hormone	14,28	IGFBP-3	206,213	growth hormone	IGFBP-3	2688	3486	Gene	Gene	treatment|amod|START_ENTITY treatment|dep|changes changes|nmod|insulin-like_growth_factor-1 insulin-like_growth_factor-1|appos|END_ENTITY	Supplementary growth_hormone treatment of women with poor ovarian response to exogenous gonadotrophins : changes in serum and follicular fluid insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- .
10224108	0	growth_hormone	17,31	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	START_ENTITY|nsubj|inhibits inhibits|compound|END_ENTITY	Insulin inhibits growth_hormone signaling via the growth_hormone receptor/JAK2/STAT5B pathway .
10442567	0	growth_hormone	23,37	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Insulin sensitivity in growth_hormone -LRB- GH -RRB- - deficient adults and effect of GH replacement therapy .
16439844	0	growth_hormone	35,49	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	deficiency|amod|START_ENTITY adults|nmod|deficiency sensitivity|nmod|adults sensitivity|compound|END_ENTITY	Insulin sensitivity in adults with growth_hormone deficiency and effect of growth_hormone treatment .
16439844	0	growth_hormone	75,89	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	treatment|amod|START_ENTITY sensitivity|nmod|treatment sensitivity|compound|END_ENTITY	Insulin sensitivity in adults with growth_hormone deficiency and effect of growth_hormone treatment .
2903152	0	growth_hormone	42,56	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Insulin regulates expression of the human growth_hormone gene in transfected cells .
360062	0	growth_hormone	52,66	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	Insulin binding and insulin sensitivity in isolated growth_hormone deficiency .
7042427	0	growth_hormone	127,141	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	levels|compound|START_ENTITY glucose|appos|levels absorption|dep|glucose absorption|compound|END_ENTITY	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise : blood glucose , plasma insulin , growth_hormone , adrenaline and noradrenaline levels .
719944	0	growth_hormone	106,120	Insulin	1,8	growth hormone	Insulin	2688	3630	Gene	Gene	reactions|nmod|START_ENTITY antagonist|nmod|reactions antagonist|nsubj|therapy therapy|compound|END_ENTITY	-LSB- Insulin therapy and behaviors of insulin antagonist hormones , with special reference to the reactions of growth_hormone and cortisol during the hypoglycemic stage in juvenile diabetes -RSB- .
8582710	0	growth_hormone	32,46	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Insulin antagonistic effects of growth_hormone in short children .
9326618	0	growth_hormone	82,96	Insulin	0,7	growth hormone	Insulin	2688	3630	Gene	Gene	receptors|amod|START_ENTITY translocation|nmod|receptors inhibit|dobj|translocation inhibit|nsubj|factor-I factor-I|compound|END_ENTITY	Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth_hormone receptors in osteoblasts : a novel mechanism of growth_hormone receptor regulation .
1658632	0	growth_hormone	52,66	Insulin-like_growth_factor-I	0,28	growth hormone	Insulin-like growth factor-I	2688	3479	Gene	Gene	attenuation|nmod|START_ENTITY attenuation|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- attenuation of growth_hormone is enhanced by overexpression of pituitary IGF-I_receptors .
18521839	0	growth_hormone	140,154	Insulin-like_growth_factor-I	0,28	growth hormone	Insulin-like growth factor-I	2688	3479	Gene	Gene	administration|amod|START_ENTITY distribution|nmod|administration END_ENTITY|dep|distribution	Insulin-like_growth_factor-I of pejerrey , Odontesthes bonariensis : cDNA characterization , tissue distribution and expression profiles after growth_hormone administration .
22562529	0	growth_hormone	58,72	Insulin-like_growth_factor-I	0,28	growth hormone	Insulin-like growth factor-I	2688	3479	Gene	Gene	closely|nmod|START_ENTITY correlates|advmod|closely correlates|nsubj|END_ENTITY	Insulin-like_growth_factor-I correlates more closely than growth_hormone with insulin resistance and glucose_intolerance in patients with acromegaly .
8858219	0	growth_hormone	91,105	Insulin-like_growth_factor-I	0,28	growth hormone	Insulin-like growth factor-I	2688	3479	Gene	Gene	pulse|amod|START_ENTITY induced|nmod|pulse mobilization|acl|induced enhances|dobj|mobilization enhances|nsubj|END_ENTITY	Insulin-like_growth_factor-I in man enhances lipid mobilization and oxidation induced by a growth_hormone pulse .
9078817	0	growth_hormone	68,82	Insulin-like_growth_factor-I	0,28	growth hormone	Insulin-like growth factor-I	2688	3479	Gene	Gene	_|amod|START_ENTITY diagnosis|nmod|_ screening|nmod|diagnosis screening|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- IGF-I -RRB- screening for the diagnosis of growth_hormone _ -LRB- GH -RRB- _ deficiency .
9390011	0	growth_hormone	116,130	Insulin-like_growth_factor-I	0,28	growth hormone	Insulin-like growth factor-I	2688	24482(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY RNAs|nmod|injection RNAs|nsubj|END_ENTITY	Insulin-like_growth_factor-I , actin , and myosin heavy chain messenger RNAs in skeletal muscle after an injection of growth_hormone in subjects over 60 years old .
9084006	0	growth_hormone	61,75	Insulin-like_growth_factor_1	0,28	growth hormone	Insulin-like growth factor 1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	has|nsubj|START_ENTITY has|advcl|has has|nsubj|END_ENTITY	Insulin-like_growth_factor_1 has beneficial effects , whereas growth_hormone has limited effects on postoperative protein metabolism , gut integrity , and splenic weight in rats with chronic mild liver_injury .
10537147	0	growth_hormone	78,92	Insulin-like_growth_factor_I	0,28	growth hormone	Insulin-like growth factor I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	essential|xcomp|START_ENTITY essential|nsubj|END_ENTITY	Insulin-like_growth_factor_I is essential for postnatal growth in response to growth_hormone .
15583470	0	growth_hormone	88,102	Insulin-like_growth_factor_I	0,28	growth hormone	Insulin-like growth factor I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY markers|nmod|deficiency END_ENTITY|nmod|markers	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein_3 as diagnostic markers of growth_hormone deficiency in infancy .
16039893	0	growth_hormone	53,67	Insulin-like_growth_factor_I	0,28	growth hormone	Insulin-like growth factor I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Insulin-like_growth_factor_I -LRB- IGF-I -RRB- measurements in growth_hormone -LRB- GH -RRB- therapy of idiopathic_short_stature -LRB- ISS -RRB- .
3016022	0	growth_hormone	39,53	Insulin-like_growth_factor_I	0,28	growth hormone	Insulin-like growth factor I	2688	3479	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Insulin-like_growth_factor_I regulates growth_hormone secretion and messenger ribonucleic_acid levels in human pituitary_tumor cells .
8282965	0	growth_hormone	93,107	Insulin-like_growth_factor_I	0,28	growth hormone	Insulin-like growth factor I	2688	3479	Gene	Gene	levels|compound|START_ENTITY relationship|nmod|levels values|dep|relationship values|amod|END_ENTITY	Insulin-like_growth_factor_I values in patients on maintenance hemodialysis : relationship to growth_hormone and albumin levels .
8664976	0	growth_hormone	101,115	Insulin-like_growth_factor_I	0,28	growth hormone	Insulin-like growth factor I	2688	3479	Gene	Gene	comparison|nmod|START_ENTITY metabolism|dep|comparison alters|dobj|metabolism alters|nsubj|END_ENTITY	Insulin-like_growth_factor_I alters peripheral thyroid hormone metabolism in humans : comparison with growth_hormone .
8726240	0	growth_hormone	69,83	Insulin-like_growth_factor_binding_protein-3	0,44	growth hormone	Insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	insensitivity|amod|START_ENTITY index|nmod|insensitivity generation|dep|index generation|amod|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 generation : an index of growth_hormone insensitivity .
3805277	0	growth_hormone	42,56	Insulinlike_growth_factor_I	0,27	growth hormone	Insulinlike growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|compound|END_ENTITY	Insulinlike_growth_factor_I regulation of growth_hormone gene transcription in primary rat pituitary cells .
15831712	0	growth_hormone	72,86	Interleukin-1	0,13	growth hormone	Interleukin-1	2688	3552	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth_hormone in CWSV-1 hepatocytes .
12519742	0	growth_hormone	31,45	Interleukin-6	0,13	growth hormone	Interleukin-6	14599(Tax:10090)	16193(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-6 inhibits hepatic growth_hormone signaling via upregulation of Cis and Socs-3 .
7525556	0	growth_hormone	66,80	JAK1	41,45	growth hormone	JAK1	2688	3716	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Differential tyrosine phosphorylation of JAK1 , JAK2 , and STAT1 by growth_hormone and interferon-gamma in IM-9 cells .
10912517	0	growth_hormone	59,73	JAK2	28,32	growth hormone	JAK2	2688	3717	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Role of the tyrosine kinase JAK2 in signal transduction by growth_hormone .
8537333	0	growth_hormone	124,138	JAK2	0,4	growth hormone	JAK2	2688	3717	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	JAK2 , Ras , and Raf are required for activation of extracellular signal-regulated kinase/mitogen-activated protein kinase by growth_hormone .
10506588	0	growth_hormone	41,55	Kallikrein-binding_protein	0,26	growth hormone	Kallikrein-binding protein	81668(Tax:10116)	24794(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Kallikrein-binding_protein is induced by growth_hormone in the dwarf rat .
10651760	0	growth_hormone	64,78	Leptin	0,6	growth hormone	Leptin	2688	3952	Gene	Gene	START_ENTITY|nsubj|concentrations concentrations|compound|END_ENTITY	Leptin concentrations in Prader-Willi_syndrome before and after growth_hormone replacement .
12970164	0	growth_hormone	15,29	Leptin	0,6	growth hormone	Leptin	2688	3952	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Leptin induces growth_hormone secretion from peripheral blood mononuclear cells via a protein_kinase_C - and nitric_oxide-dependent mechanism .
15153755	0	growth_hormone	18,32	Leptin	0,6	growth hormone	Leptin	2688	3952	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Leptin stimulates growth_hormone secretion via a direct pituitary effect combined with a decreased somatostatin tone in a median eminence-pituitary perifusion study .
18445667	0	growth_hormone	62,76	Leptin	0,6	growth hormone	Leptin	2688	3952	Gene	Gene	pulsatility|amod|START_ENTITY mediate|nmod|pulsatility mediate|nsubj|END_ENTITY	Leptin does not mediate short-term fasting-induced changes in growth_hormone pulsatility but increases IGF-I in leptin_deficiency states .
26403688	0	growth_hormone	25,39	Leptin	0,6	growth hormone	Leptin	378781(Tax:9031)	373955(Tax:9031)	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Leptin activates chicken growth_hormone promoter without chicken STAT3 in vitro .
9724042	0	growth_hormone	55,69	Leptin	0,6	growth hormone	Leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY stimulator|nmod|secretion stimulator|nsubj|END_ENTITY	Leptin is a potent stimulator of spontaneous pulsatile growth_hormone -LRB- GH -RRB- secretion and the GH response to GH-releasing_hormone .
16815061	0	growth_hormone	48,62	MMP-2	0,5	growth hormone	MMP-2	81668(Tax:10116)	81686(Tax:10116)	Gene	Gene	increased|nmod|START_ENTITY increased|nsubjpass|END_ENTITY	MMP-2 in the left rat ventricle is increased by growth_hormone .
2884793	0	growth_hormone	33,47	Neuropeptide_Y	0,14	growth hormone	Neuropeptide Y	2688	4852	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Neuropeptide_Y directly inhibits growth_hormone secretion by human pituitary_somatotropic_tumours .
14638744	0	growth_hormone	22,36	Opticin	0,7	growth hormone	Opticin	378781(Tax:9031)	395130(Tax:9031)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Opticin binds retinal growth_hormone in the embryonic vitreous .
24691732	0	growth_hormone	20,34	Osteocalcin	0,11	growth hormone	Osteocalcin	14599(Tax:10090)	12097(Tax:10090)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Osteocalcin induces growth_hormone / insulin-like growth factor-1 system by promoting testosterone synthesis in male mice .
23380306	0	growth_hormone	152,166	PIT-1	56,61	growth hormone	PIT-1	2688	5449	Gene	Gene	effects|nmod|START_ENTITY insights|nmod|effects profiling|dep|insights profiling|nmod|adolescent adolescent|nmod|mutation mutation|compound|END_ENTITY	Urine metabonomic profiling of a female adolescent with PIT-1 mutation before and during growth_hormone therapy : insights into the metabolic effects of growth_hormone .
8098921	0	growth_hormone	108,122	PIT-1	82,87	growth hormone	PIT-1	81668(Tax:10116)	397325(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY controlling|dobj|expression gene|acl|controlling END_ENTITY|appos|gene	Cloning and restriction fragment length polymorphism analysis of a cDNA for swine PIT-1 , a gene controlling growth_hormone expression .
20375207	0	growth_hormone	63,77	Peptide_YY	0,10	growth hormone	Peptide YY	2688	5697	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Peptide_YY levels across pubertal stages and associations with growth_hormone .
10411306	0	growth_hormone	15,29	Pit-1	114,119	growth hormone	Pit-1	403795(Tax:9615)	403753(Tax:9615)	Gene	Gene	transcription|amod|START_ENTITY initiates|nsubj|transcription initiates|nmod|site site|nmod|absence absence|nmod|END_ENTITY	Canine mammary growth_hormone gene transcription initiates at the pituitary-specific start site in the absence of Pit-1 .
11149379	0	growth_hormone	29,43	Pit-1	45,50	growth hormone	Pit-1	2688	5449	Gene	Gene	START_ENTITY|dep|dependence dependence|compound|END_ENTITY	Pituitary and extrapituitary growth_hormone : Pit-1 dependence ?
11874696	0	growth_hormone	79,93	Pit-1	24,29	growth hormone	Pit-1	14599(Tax:10090)	18736(Tax:10090)	Gene	Gene	induces|ccomp|START_ENTITY induces|nsubj|expression expression|nmod|END_ENTITY	Exogenous expression of Pit-1 in AtT-20 corticotropic cells induces endogenous growth_hormone gene transcription .
1454833	0	growth_hormone	62,76	Pit-1	49,54	growth hormone	Pit-1	2688	5449	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Activin inhibits binding of transcription factor Pit-1 to the growth_hormone promoter .
15595273	0	growth_hormone	14,28	Pit-1	125,130	growth hormone	Pit-1	378781(Tax:9031)	374215(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of growth_hormone expression by thyrotropin-releasing_hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary .
17047377	0	growth_hormone	24,38	Pit-1	70,75	growth hormone	Pit-1	2688	5449	Gene	Gene	family|amod|START_ENTITY Regulation|nmod|family Regulation|dep|role role|nmod|END_ENTITY	Regulation of the human growth_hormone gene family : possible role for Pit-1 in early stages of pituitary-specific expression and repression .
18602461	0	growth_hormone	25,39	Pit-1	132,137	growth hormone	Pit-1	14599(Tax:10090)	18736(Tax:10090)	Gene	Gene	Reduction|nmod|START_ENTITY associated|nsubjpass|Reduction associated|nmod|suppression suppression|compound|END_ENTITY	Reduction in hypophyseal growth_hormone and prolactin expression due to deficiency in ghrelin_receptor signaling is associated with Pit-1 suppression : relevance to the immune system .
19427323	0	growth_hormone	63,77	Pit-1	14,19	growth hormone	Pit-1	2688	5449	Gene	Gene	locus|compound|START_ENTITY control|nsubj|locus induces|ccomp|control induces|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Pit-1 in nonsomatotrope cell lines induces human growth_hormone locus control region histone modification and hGH-N transcription .
21703269	0	growth_hormone	45,59	Pit-1	16,21	growth hormone	Pit-1	378781(Tax:9031)	374215(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY activating|dobj|gene isoforms|advcl|activating isoforms|nsubj|Role Role|nmod|END_ENTITY	Role of chicken Pit-1 isoforms in activating growth_hormone gene .
2211620	0	growth_hormone	71,85	Pit-1	12,17	growth hormone	Pit-1	81668(Tax:10116)	25517(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY essential|nmod|activity essential|nsubj|END_ENTITY	Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth_hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding .
2211620	0	growth_hormone	71,85	Pit-1	136,141	growth hormone	Pit-1	81668(Tax:10116)	25517(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY essential|nmod|activity essential|nmod|END_ENTITY	Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth_hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding .
2550324	0	growth_hormone	54,68	Pit-1	32,37	growth hormone	Pit-1	2688	5449	Gene	Gene	promoters|compound|START_ENTITY activates|dobj|promoters activates|nsubj|protein protein|appos|END_ENTITY	A pituitary POU domain protein , Pit-1 , activates both growth_hormone and prolactin promoters transcriptionally .
7836893	0	growth_hormone	66,80	Pit-1	40,45	growth hormone	Pit-1	81668(Tax:10116)	25517(Tax:10116)	Gene	Gene	dwarfism|amod|START_ENTITY rat|nmod|dwarfism transcription|nmod|rat transcription|dobj|END_ENTITY	Pituitary-specific transcription factor Pit-1 in the rdw rat with growth_hormone - and prolactin-deficient dwarfism .
7920986	0	growth_hormone	24,38	Pit-1	0,5	growth hormone	Pit-1	2688	5449	Gene	Gene	regulation|amod|START_ENTITY role|nmod|regulation role|compound|END_ENTITY	Pit-1 and Pit-2 role in growth_hormone gene regulation .
8316253	0	growth_hormone	101,115	Pit-1	33,38	growth hormone	Pit-1	81668(Tax:10116)	25517(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY required|nmod|expression required|nsubjpass|interactions interactions|nmod|END_ENTITY	Synergistic interactions between Pit-1 and other elements are required for effective somatotroph rat growth_hormone gene expression in transgenic_mice .
8441408	0	growth_hormone	103,117	Pit-1	18,23	growth hormone	Pit-1	81668(Tax:10116)	25517(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression GHF-1|dep|stimulation Ligand-dependent|parataxis|GHF-1 Ligand-dependent|dep|END_ENTITY	Ligand-dependent , Pit-1 / growth_hormone_factor-1 -LRB- GHF-1 -RRB- - independent transcriptional stimulation of rat growth_hormone gene expression by thyroid hormone receptors in vitro .
8730655	0	growth_hormone	54,68	Pit-1	46,51	growth hormone	Pit-1	81668(Tax:10116)	25517(Tax:10116)	Gene	Gene	START_ENTITY|nmod|pituitary_transcription_factor-1 pituitary_transcription_factor-1|appos|END_ENTITY	Ontogeny of pituitary_transcription_factor-1 -LRB- Pit-1 -RRB- , growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- mRNA levels in male and female rats and the differential expression of Pit-1 in lactotrophs and somatotrophs .
8879985	0	growth_hormone	40,54	Pit-1	8,13	growth hormone	Pit-1	2688	5449	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of Pit-1 in the gene expression of growth_hormone , prolactin , and thyrotropin .
9392393	0	growth_hormone	35,49	Pit-1	100,105	growth hormone	Pit-1	2688	5449	Gene	Gene	pituitary_deficiencies|nmod|START_ENTITY stimulating|nmod|pituitary_deficiencies stimulating|xcomp|due due|nmod|mutation mutation|compound|END_ENTITY	Combined pituitary_deficiencies of growth_hormone , thyroid stimulating hormone and prolactin due to Pit-1 gene mutation : a case report .
9626142	0	growth_hormone	94,108	Pit-1	45,50	growth hormone	Pit-1	2688	5449	Gene	Gene	children|nmod|START_ENTITY gene|nmod|children gene|compound|END_ENTITY	Pro239Ser : a novel recessive mutation of the Pit-1 gene in seven Middle Eastern children with growth_hormone , prolactin , and thyrotropin_deficiency .
15462883	0	growth_hormone	49,63	Plerocercoid_growth_factor	0,26	growth hormone	Plerocercoid growth factor	2688	5228	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|dep|homologue	Plerocercoid_growth_factor : a homologue of human growth_hormone .
5529569	0	growth_hormone	45,59	Prolactin	0,9	growth hormone	Prolactin	2688	5617	Gene	Gene	separate|nmod|START_ENTITY evidence|dep|separate END_ENTITY|dep|evidence	Prolactin : evidence that it is separate from growth_hormone in human blood .
6412497	0	growth_hormone	76,90	Prolactin	0,9	growth hormone	Prolactin	2688	5617	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency thyroliberin|nmod|patients responses|nmod|thyroliberin responses|compound|END_ENTITY	Prolactin and thyrotrophin responses to thyroliberin -LRB- TRH -RRB- in patients with growth_hormone deficiency : study in 167 patients .
7851719	0	growth_hormone	11,25	Prolactin	0,9	growth hormone	Prolactin	378781(Tax:9031)	396453(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prolactin , growth_hormone , and luteinizing hormone-beta subunit gene expression in the cephalic and caudal lobes of the anterior pituitary gland during embryogenesis and different reproductive stages in the chicken .
9442080	0	growth_hormone	75,89	SHP-2	66,71	growth hormone	SHP-2	14599(Tax:10090)	19247(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Involvement of the Src homology 2-containing tyrosine phosphatase SHP-2 in growth_hormone signaling .
17609438	0	growth_hormone	59,73	SOC3	50,54	growth hormone	SOC3	2688	9021	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOC3 -RRB- by growth_hormone in pro-B cells .
10403376	0	growth_hormone	61,75	SOCS-2	50,56	growth hormone	SOCS-2	2688	8835	Gene	Gene	transduction|amod|START_ENTITY effects|nmod|transduction effects|appos|END_ENTITY	Dual effects of suppressor_of_cytokine_signaling -LRB- SOCS-2 -RRB- on growth_hormone signal transduction .
12208853	0	growth_hormone	79,93	SOCS-2	25,31	growth hormone	SOCS-2	14599(Tax:10090)	216233(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY enhancer|nmod|signaling act|nmod|enhancer act|nsubj|evidence evidence|dep|END_ENTITY	Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth_hormone signaling .
10998044	0	growth_hormone	66,80	SOCS-3	36,42	growth hormone	SOCS-3	81668(Tax:10116)	89829(Tax:10116)	Gene	Gene	analysis|amod|START_ENTITY hepatocytes|nmod|analysis Regulation|nmod|hepatocytes Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of expression of the rat SOCS-3 gene in hepatocytes by growth_hormone , interleukin-6 and glucocorticoids mRNA analysis and promoter characterization .
12734778	0	growth_hormone	78,92	SOCS-3	0,6	growth hormone	SOCS-3	81668(Tax:10116)	89829(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY downregulation|nmod|effects involved|nmod|downregulation involved|nsubjpass|END_ENTITY	SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth_hormone in rat adipocytes by inhibition of Jak2/IRS -1 signaling .
9045884	1	growth_hormone	118,132	SSTR2	98,103	growth hormone	SSTR2	2688	6752	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of SSTR2 and SSTR5 for growth_hormone , thyroid-stimulating hormone , and prolactin regulation .
10585851	0	growth_hormone	53,67	STAT5	188,193	growth hormone	STAT5	81668(Tax:10116)	24918(Tax:10116)	Gene	Gene	proliferation|nmod|START_ENTITY Stimulation|nmod|proliferation glucose-dependent|nsubj|Stimulation glucose-dependent|parataxis|substrate-mediated substrate-mediated|nsubj|transduction transduction|nmod|janus_kinase_2 janus_kinase_2|dep|signal_transducer_and_activator_of_transcription_5 signal_transducer_and_activator_of_transcription_5|appos|END_ENTITY	Stimulation of pancreatic beta-cell proliferation by growth_hormone is glucose-dependent : signal transduction via janus_kinase_2 -LRB- JAK2 -RRB- / signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- with no crosstalk to insulin receptor substrate-mediated mitogenic signalling .
10674400	0	growth_hormone	165,179	STAT5	15,20	growth hormone	STAT5	81668(Tax:10116)	24918(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY control|nmod|gene Involvement|nmod|control Involvement|nmod|END_ENTITY	Involvement of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- and HNF-4 -LRB- hepatocyte_nuclear_factor_4 -RRB- in the transcriptional control of the hnf6 gene by growth_hormone .
23631823	0	growth_hormone	32,46	STAT5	56,61	growth hormone	STAT5	14599(Tax:10090)	20850(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of insulin and IGF-I on growth_hormone - induced STAT5 activation in 3T3-F442A adipocytes .
8732682	0	growth_hormone	76,90	STAT5	32,37	growth hormone	STAT5	2688	6776	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization and cloning of STAT5 from IM-9 cells and its activation by growth_hormone .
23896798	0	growth_hormone	26,40	STAT5B	1,7	growth hormone	STAT5B	2688	6777	Gene	Gene	insensitivity_syndrome|compound|START_ENTITY deficiency|dep|insensitivity_syndrome deficiency|compound|END_ENTITY	-LSB- STAT5B deficiency : a new growth_hormone insensitivity_syndrome associated to immunological_dysfunction -RSB- .
10991939	0	growth_hormone	100,114	STAT5b	69,75	growth hormone	STAT5b	81668(Tax:10116)	25126(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Role of the cytokine-inducible SH2 protein CIS in desensitization of STAT5b signaling by continuous growth_hormone .
11562369	0	growth_hormone	100,114	STAT5b	30,36	growth hormone	STAT5b	81668(Tax:10116)	25126(Tax:10116)	Gene	Gene	liver|amod|START_ENTITY expression|compound|liver regulation|nmod|expression impact|nmod|regulation HNF3beta|dep|impact HNF3beta|amod|cross-talk cross-talk|nmod|END_ENTITY	Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta : impact on the regulation of growth_hormone pulse-stimulated , male-specific liver cytochrome_P-450 gene expression .
18831980	0	growth_hormone	58,72	STAT5b	88,94	growth hormone	STAT5b	14599(Tax:10090)	20851(Tax:10090)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Increased SULT1E1 activity in HepG2 hepatocytes decreases growth_hormone stimulation of STAT5b phosphorylation .
752593	0	growth_hormone	63,77	STH	79,82	growth hormone	STH	2688	246744	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Animal experiments on the modification of fracture healing by growth_hormone -LRB- STH -RRB- -RSB- .
6541432	0	growth_hormone	26,40	Somatomedin_C	0,13	growth hormone	Somatomedin C	2688	3479	Gene	Gene	START_ENTITY|nsubj|response response|amod|END_ENTITY	Somatomedin_C response to growth_hormone in psychosocial_growth_retardation .
1976219	0	growth_hormone	55,69	Somatostatin	0,12	growth hormone	Somatostatin	443329(Tax:9940)	443006(Tax:9940)	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|secretion secretion|compound|END_ENTITY	Somatostatin secretion and action in the regulation of growth_hormone secretion .
1977278	0	growth_hormone	88,102	Somatostatin	0,12	growth hormone	Somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY regulating|dobj|secretion significance|advcl|regulating significance|nsubj|END_ENTITY	Somatostatin and its physiological significance in regulating the episodic secretion of growth_hormone in the rat .
20943754	0	growth_hormone	126,140	Somatostatin	0,12	growth hormone	Somatostatin	14599(Tax:10090)	20604(Tax:10090)	Gene	Gene	axis|amod|START_ENTITY control|nmod|axis contribute|nmod|control contribute|nsubj|END_ENTITY	Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic -LRB- fed/fasting -RRB- control of growth_hormone axis in mice .
2862637	0	growth_hormone	36,50	Somatostatin	0,12	growth hormone	Somatostatin	403795(Tax:9615)	403993(Tax:9615)	Gene	Gene	effect|nmod|START_ENTITY surges|nsubj|effect mediates|ccomp|surges mediates|nsubj|END_ENTITY	Somatostatin mediates the effect of growth_hormone surges on splanchnic biogenic amines .
2878057	0	growth_hormone	32,46	Somatostatin	0,12	growth hormone	Somatostatin	443329(Tax:9940)	443006(Tax:9940)	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Somatostatin tonically inhibits growth_hormone secretion in domestic fowl .
2900199	0	growth_hormone	55,69	Somatostatin	0,12	growth hormone	Somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Somatostatin as a physiological regulator of pulsatile growth_hormone secretion .
7679974	0	growth_hormone	42,56	Somatostatin	0,12	growth hormone	Somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY transcription|nmod|gene reduces|dobj|transcription reduces|nsubj|END_ENTITY	Somatostatin reduces transcription of the growth_hormone gene in rats .
7904112	0	growth_hormone	71,85	Somatostatin	0,12	growth hormone	Somatostatin	2688	6750	Gene	Gene	release|compound|START_ENTITY generator|nmod|release generator|nsubj|withdrawal withdrawal|compound|END_ENTITY	Somatostatin withdrawal alone is an ineffective generator of pulsatile growth_hormone release in man .
8536603	0	growth_hormone	23,37	Somatostatin	0,12	growth hormone	Somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	Somatostatin increases growth_hormone -LRB- GH -RRB- secretion in a subpopulation of porcine somatotropes : evidence for functional and morphological heterogeneity among porcine GH-producing cells .
12682066	0	growth_hormone	68,82	Stat5b	91,97	growth hormone	Stat5b	14599(Tax:10090)	20851(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Acute control of insulin-like_growth_factor-I gene transcription by growth_hormone through Stat5b .
16303763	0	growth_hormone	43,57	Stat5b	29,35	growth hormone	Stat5b	2688	6777	Gene	Gene	insensitivity_and_proteasomal_dysfunction|amod|START_ENTITY causes|dobj|insensitivity_and_proteasomal_dysfunction causes|nsubj|folding folding|nmod|END_ENTITY	Aberrant folding of a mutant Stat5b causes growth_hormone insensitivity_and_proteasomal_dysfunction .
15125881	0	growth_hormone	53,67	Suppressors_of_cytokine_signalling	0,34	growth hormone	Suppressors of cytokine signalling	14599(Tax:10090)	12700(Tax:10090)	Gene	Gene	action|amod|START_ENTITY END_ENTITY|nmod|action	Suppressors_of_cytokine_signalling and regulation of growth_hormone action .
23643167	0	growth_hormone	29,43	TNF-a	64,69	growth hormone	TNF-a	2688	7124	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of recombinant human growth_hormone on the secretion of TNF-a and IL-6 by THP-1 cells and its correlation with the NF-kB pathway -RSB- .
9013974	0	growth_hormone	21,35	TNF-alpha	39,48	growth hormone	TNF-alpha	2688	7124	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	Inhibitory effect of growth_hormone on TNF-alpha secretion and nuclear factor-kappaB translocation in lipopolysaccharide-stimulated human monocytes .
828709	0	growth_hormone	8,22	TRH	55,58	growth hormone	TRH	2688	7200	Gene	Gene	responsiveness|nsubj|START_ENTITY responsiveness|xcomp|END_ENTITY	Altered growth_hormone and prolactin responsiveness to TRH in the infant rat .
17706597	0	growth_hormone	16,30	TTF-1	0,5	growth hormone	TTF-1	81668(Tax:10116)	499766(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	TTF-1 regulates growth_hormone and prolactin transcription in the anterior pituitary gland .
9682366	0	growth_hormone	105,119	Th1	76,79	growth hormone	Th1	2688	57314(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	HIV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth_hormone .
3130285	0	growth_hormone	39,53	Thyrotrophin-releasing_hormone	0,30	growth hormone	Thyrotrophin-releasing hormone	2688	7200	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Thyrotrophin-releasing_hormone induces growth_hormone secretion in adult hypothyroid fowl .
1345575	0	growth_hormone	54,68	Thyrotropin-releasing_hormone	0,29	growth hormone	Thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY suppress|dobj|response suppress|nsubj|END_ENTITY	Thyrotropin-releasing_hormone -LRB- TRH -RRB- does not suppress growth_hormone response to L-dopa in insulin-dependent diabetes_mellitus .
21554653	0	growth_hormone	39,53	Thyrotropin-releasing_hormone	0,29	growth hormone	Thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Thyrotropin-releasing_hormone mediates growth_hormone release induced by milk and nursing in neonatal rats .
3935480	0	growth_hormone	74,88	Thyrotropin-releasing_hormone	0,29	growth hormone	Thyrotropin-releasing hormone	2688	7200	Gene	Gene	secretion|compound|START_ENTITY inhibit|dobj|secretion inhibit|nsubj|END_ENTITY	Thyrotropin-releasing_hormone does not inhibit lysine_vasopressin-induced growth_hormone secretion in normal men .
4364640	0	growth_hormone	73,87	Thyrotropin-releasing_hormone	0,29	growth hormone	Thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulation and somatostatin inhibition of growth_hormone secretion from perfused rat adenohypophyses .
7808594	0	growth_hormone	54,68	Thyrotropin-releasing_hormone	0,29	growth hormone	Thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY function|nmod|neurons END_ENTITY|dep|function	Thyrotropin-releasing_hormone : inhibitory function on growth_hormone through both somatostatin and growth_hormone-releasing factor neurons .
16530883	0	growth_hormone	37,51	Trp3	1,5	growth hormone	Trp3	14599(Tax:10090)	22065(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	-LSB- Trp3 , Arg5 -RSB- - ghrelin -LRB- 1-5 -RRB- stimulates growth_hormone secretion and food intake via growth_hormone_secretagogue _ -LRB- GHS -RRB- _ receptor .
2752985	0	growth_hormone	37,51	Tumor_necrosis_factor-alpha	0,27	growth hormone	Tumor necrosis factor-alpha	81668(Tax:10116)	24835(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits growth_hormone secretion from cultured anterior pituitary cells .
6424471	0	growth_hormone	103,117	VIII	70,74	growth hormone	VIII	2688	1351	Gene	Gene	infusion|compound|START_ENTITY response|nmod|infusion response|nummod|END_ENTITY	Lack of von_Willebrand factor , factor VIII related antigen and factor VIII coagulant response to human growth_hormone infusion in type 2 diabetes_mellitus .
6438437	0	growth_hormone	11,25	VIII	40,44	growth hormone	VIII	2688	1351	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of growth_hormone on the factor VIII complex in patients with growth_hormone deficiency .
6438437	0	growth_hormone	70,84	VIII	40,44	growth hormone	VIII	2688	1351	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency complex|nmod|patients END_ENTITY|xcomp|complex	Effects of growth_hormone on the factor VIII complex in patients with growth_hormone deficiency .
10970071	0	growth_hormone	53,67	VIP	45,48	growth hormone	VIP	2688	7432	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- release and cell morphology in human pituitary_adenoma_cell_cultures .
17003095	0	growth_hormone	10,24	adiponectin	42,53	growth hormone	adiponectin	2688	9370	Gene	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Effect of growth_hormone therapy on serum adiponectin and resistin levels in short , small-for-gestational-age children and associations with cardiovascular risk parameters .
20061428	0	growth_hormone	89,103	adiponectin	15,26	growth hormone	adiponectin	2688	9370	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|expression expression|compound|END_ENTITY	Correlation of adiponectin receptor expression with cytokines and insulin sensitivity in growth_hormone -LRB- GH -RRB- - treated children with Prader-Willi_syndrome and in non-GH-treated obese children .
15582725	0	growth_hormone	40,54	agouti-related_protein	14,36	growth hormone	agouti-related protein	81668(Tax:10116)	25582(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of agouti-related_protein on growth_hormone secretion in adult male rats .
3793013	0	growth_hormone	10,24	alcohol_dehydrogenase	28,49	growth hormone	alcohol dehydrogenase	81668(Tax:10116)	78959(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of growth_hormone on alcohol_dehydrogenase activity in hepatocyte culture .
165218	0	growth_hormone	34,48	alpha-MSH	14,23	growth hormone	alpha-MSH	2688	5443	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of alpha-MSH on plasma growth_hormone , cortisol and TSH in children .
3372809	0	growth_hormone	62,76	alpha-lactalbumin	80,97	growth hormone	alpha-lactalbumin	14599(Tax:10090)	281894(Tax:9913)	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Influence of recombinant deoxyribonucleic_acid-derived bovine growth_hormone on alpha-lactalbumin production by bovine mammary tissue maintained in athymic nude_mice .
6177693	0	growth_hormone	65,79	alpha_2u-globulin	31,48	growth hormone	alpha 2u-globulin	81668(Tax:10116)	298111(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Pretranslational regulation of alpha_2u-globulin in rat liver by growth_hormone .
11713892	0	growth_hormone	11,25	angiotensin-converting_enzyme	44,73	growth hormone	angiotensin-converting enzyme	81668(Tax:10116)	24310(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	Effects of growth_hormone following chronic angiotensin-converting_enzyme inhibition in chronic_heart_failure : their relation to infarct size .
2126223	0	growth_hormone	100,114	angiotensin_II	82,96	growth hormone	angiotensin II	81668(Tax:10116)	24179(Tax:10116)	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Evidence for a pertussis toxin-sensitive signalling pathway in the dual action of angiotensin_II on growth_hormone release in pituitary cell aggregates .
2170820	0	growth_hormone	15,29	angiotensin_II	59,73	growth hormone	angiotensin II	2688	183	Gene	Gene	Stimulation|nmod|START_ENTITY release|nsubj|Stimulation release|nmod|END_ENTITY	Stimulation of growth_hormone and corticotropin release by angiotensin_II in man .
11093922	0	growth_hormone	18,32	apolipoprotein_B	64,80	growth hormone	apolipoprotein B	81668(Tax:10116)	54225(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Direct effects of growth_hormone on production and secretion of apolipoprotein_B from rat hepatocytes .
15070948	0	growth_hormone	11,25	apolipoprotein_B100	78,97	growth hormone	apolipoprotein B100	2688	338	Gene	Gene	therapy|amod|START_ENTITY therapy|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- replacement therapy on low-density lipoprotein apolipoprotein_B100 kinetics in adult patients with GH_deficiency : a stable isotope study .
1333608	0	growth_hormone	117,131	atrial_natriuretic_peptide	23,49	growth hormone	atrial natriuretic peptide	81668(Tax:10116)	24602(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	The role of endogenous atrial_natriuretic_peptide in resting and stress-induced release of corticotropin , prolactin , growth_hormone , and thyroid-stimulating hormone .
2180981	0	growth_hormone	11,25	bone_Gla_protein	41,57	growth hormone	bone Gla protein	2688	632	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone -LRB- GH -RRB- on plasma bone_Gla_protein in GH-deficient adults .
2370291	0	growth_hormone	46,60	bone_Gla_protein	6,22	growth hormone	bone Gla protein	2688	632	Gene	Gene	deficiency|amod|START_ENTITY marker|nmod|deficiency END_ENTITY|dep|marker	Serum bone_Gla_protein : a potential marker of growth_hormone -LRB- GH -RRB- deficiency and the response to GH therapy .
8341690	0	growth_hormone	61,75	c-fos	52,57	growth hormone	c-fos	2688	2353	Gene	Gene	mediate|nmod|START_ENTITY mediate|dobj|induction induction|nmod|END_ENTITY	The serum response element can mediate induction of c-fos by growth_hormone .
8462486	0	growth_hormone	49,63	c-fos	14,19	growth hormone	c-fos	2688	2353	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of c-fos proto-oncogene expression by growth_hormone : protein synthesis is not required for down-regulation .
8580424	0	growth_hormone	126,140	c-fos	13,18	growth hormone	c-fos	14599(Tax:10090)	14281(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY nucleus|nmod|mice mRNA|nmod|nucleus mRNA|amod|END_ENTITY	Induction of c-fos mRNA in the arcuate nucleus of normal and mutant growth_hormone-deficient mice by a synthetic non-peptidyl growth_hormone secretagogue .
2480191	0	growth_hormone	11,25	c-myc	47,52	growth hormone	c-myc	81668(Tax:10116)	24577(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of growth_hormone on the expression of c-myc and c-fos during early stages of sex-differentiated rat liver_carcinogenesis in the resistant hepatocyte model .
8631784	0	growth_hormone	129,143	coenzyme_A_synthase	103,122	growth hormone	coenzyme A synthase	2688	80347	Gene	Gene	gene|compound|START_ENTITY expression|dep|gene expression|nmod|END_ENTITY	Tissue-specific expression and dietary regulation of chimeric mitochondrial 3-hydroxy-3-methylglutaryl coenzyme_A_synthase / human growth_hormone gene in transgenic_mice .
6332444	0	growth_hormone	71,85	corticotrophin-releasing_factor	17,48	growth hormone	corticotrophin-releasing factor	2688	1392	Gene	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of ovine corticotrophin-releasing_factor and hydrocortisone on growth_hormone secretion by pituitary_adenoma cells of acromegaly in culture .
9579235	0	growth_hormone	65,79	corticotrophin-releasing_hormone	18,50	growth hormone	corticotrophin-releasing hormone	2688	1392	Gene	Gene	secretion|compound|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	Direct effects of corticotrophin-releasing_hormone on stimulated growth_hormone secretion .
2865691	0	growth_hormone	63,77	corticotropin-releasing_factor	99,129	growth hormone	corticotropin-releasing factor	81668(Tax:10116)	81648(Tax:10116)	Gene	Gene	suppression|nmod|START_ENTITY somatostatin|nmod|suppression Involvement|nmod|somatostatin secretion|nsubj|Involvement secretion|nmod|END_ENTITY	Involvement of hypothalamic somatostatin in the suppression of growth_hormone secretion by central corticotropin-releasing_factor in conscious male rats .
2866087	0	growth_hormone	95,109	corticotropin-releasing_factor	15,45	growth hormone	corticotropin-releasing factor	81668(Tax:10116)	81648(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY Involvement|nmod|secretion Involvement|nmod|END_ENTITY	Involvement of corticotropin-releasing_factor and somatostatin in stress-induced inhibition of growth_hormone secretion in the rat .
6094167	0	growth_hormone	60,74	corticotropin-releasing_factor	26,56	growth hormone	corticotropin-releasing factor	2688	1392	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of synthetic ovine corticotropin-releasing_factor on growth_hormone secretion in patients with acromegaly .
10447453	0	growth_hormone	78,92	corticotropin_releasing_factor	10,40	growth hormone	corticotropin releasing factor	81668(Tax:10116)	81648(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY eminence|nmod|secretion injected|nmod|eminence injected|nsubj|Effect Effect|nmod|END_ENTITY	Effect of corticotropin_releasing_factor injected into the median eminence on growth_hormone secretion in male rats .
3415695	0	growth_hormone	11,25	cytochrome_P-450j	29,46	growth hormone	cytochrome P-450j	81668(Tax:10116)	25086(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of growth_hormone on cytochrome_P-450j .
2809491	0	growth_hormone	33,47	epidermal_growth_factor	79,102	growth hormone	epidermal growth factor	81668(Tax:10116)	1950	Gene	Gene	rhythm|nmod|START_ENTITY controls|nsubj|rhythm controls|dobj|number number|nmod|receptors receptors|compound|END_ENTITY	Differential secretory rhythm of growth_hormone controls the number of hepatic epidermal_growth_factor receptors in the rat .
6609514	0	growth_hormone	133,147	epidermal_growth_factor	56,79	growth hormone	epidermal growth factor	2688	1950	Gene	Gene	lactogen|compound|START_ENTITY growth|nmod|lactogen effects|nmod|growth Treatment|dep|effects Treatment|nmod|ewes ewes|nmod|stages stages|nmod|pregnancy pregnancy|nmod|END_ENTITY	Treatment of ewes at different stages of pregnancy with epidermal_growth_factor : effects on wool growth and plasma concentrations of growth_hormone , prolactin , placental lactogen and thyroxine and on foetal development .
10024084	0	growth_hormone	65,79	erythropoietin	39,53	growth hormone	erythropoietin	2688	2056	Gene	Gene	secretion|amod|START_ENTITY therapy|nmod|secretion therapy|compound|END_ENTITY	Long-term effects of recombinant human erythropoietin therapy on growth_hormone secretion in uremic patients undergoing peritoneal dialysis .
10698049	0	growth_hormone	53,67	erythropoietin	71,85	growth hormone	erythropoietin	2688	2056	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of long-term treatment with recombinant human growth_hormone on erythropoietin secretion in an anemic patient with panhypopituitarism .
10913939	0	growth_hormone	72,86	erythropoietin	29,43	growth hormone	erythropoietin	2688	2056	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of acute infusion of erythropoietin on paradoxical responses of growth_hormone to thyrotropin-releasing_hormone in acromegalic patients .
11895216	0	growth_hormone	56,70	erythropoietin	88,102	growth hormone	erythropoietin	2688	2056	Gene	Gene	administration|nmod|START_ENTITY Effect|nmod|administration Effect|nmod|END_ENTITY	Effect of long-term administration of recombinant human growth_hormone -LRB- rhGH -RRB- on plasma erythropoietin -LRB- EPO -RRB- and haemoglobin levels in anaemic patients with adult_GH_deficiency .
19960893	0	growth_hormone	28,42	erythropoietin	76,90	growth hormone	erythropoietin	2688	2056	Gene	Gene	therapy|compound|START_ENTITY therapy|acl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Effect of human recombinant growth_hormone therapy on circulating levels of erythropoietin and granulocyte-colony_stimulating_factor in short children .
2004477	0	growth_hormone	10,24	erythropoietin	81,95	growth hormone	erythropoietin	2688	2056	Gene	Gene	response|amod|START_ENTITY induced|nsubj|response induced|nmod|END_ENTITY	Increased growth_hormone response to growth_hormone_releasing_hormone induced by erythropoietin in uraemic patients .
7853798	0	growth_hormone	56,70	erythropoietin	13,27	growth hormone	erythropoietin	2688	2056	Gene	Gene	responses|nmod|START_ENTITY END_ENTITY|nmod|responses	Influence of erythropoietin on paradoxical responses of growth_hormone to thyrotropin-releasing_hormone in uremic patients .
8513607	0	growth_hormone	63,77	erythropoietin	18,32	growth hormone	erythropoietin	2688	2056	Gene	Gene	response|amod|START_ENTITY potentiates|dobj|response potentiates|nsubj|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
10690937	0	growth_hormone	22,36	galanin	11,18	growth hormone	galanin	2688	51083	Gene	Gene	secretion|compound|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of galanin on growth_hormone and prolactin secretion in anorexia_nervosa .
2477790	0	growth_hormone	26,40	galanin	15,22	growth hormone	galanin	2688	51083	Gene	Gene	secretion|amod|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	The effects of galanin on growth_hormone secretion in children of normal and short_stature .
6764509	0	growth_hormone	16,30	gastrin	34,41	growth hormone	gastrin	2688	2520	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of human growth_hormone on gastrin secretion in children with hyposomatotropism .
3422472	0	growth_hormone	88,102	gastrin-releasing_peptide	50,75	growth hormone	gastrin-releasing peptide	81668(Tax:10116)	171101(Tax:10116)	Gene	Gene	release|compound|START_ENTITY suppress|dobj|release END_ENTITY|xcomp|suppress	Evidence for a physiological role of hypothalamic gastrin-releasing_peptide to suppress growth_hormone and prolactin release in the rat .
4029082	0	growth_hormone	43,57	gastrin-releasing_peptide	14,39	growth hormone	gastrin-releasing peptide	81668(Tax:10116)	171101(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of gastrin-releasing_peptide on growth_hormone secretion in the rat .
6146511	0	growth_hormone	43,57	gastrin-releasing_peptide	14,39	growth hormone	gastrin-releasing peptide	2688	2922	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Inhibition by gastrin-releasing_peptide of growth_hormone -LRB- GH -RRB- secretion induced by human pancreatic GH-releasing factor in rats .
8275329	0	growth_hormone	103,117	gastrin-releasing_peptide	74,99	growth hormone	gastrin-releasing peptide	81668(Tax:10116)	171101(Tax:10116)	Gene	Gene	release|amod|START_ENTITY Determination|nmod|release Determination|nmod|requirements requirements|nmod|action action|nmod|END_ENTITY	Determination of the structural requirements for the inhibitory action of gastrin-releasing_peptide on growth_hormone release .
8963684	0	growth_hormone	46,60	gastrin-releasing_peptide	86,111	growth hormone	gastrin-releasing peptide	81668(Tax:10116)	171101(Tax:10116)	Gene	Gene	control|nmod|START_ENTITY dopamine|nmod|control Role|nmod|dopamine release|nsubj|Role release|nmod|END_ENTITY	Role of dopamine in the inhibitory control of growth_hormone and prolactin release by gastrin-releasing_peptide .
11231996	0	growth_hormone	80,94	gh	96,98	growth hormone	gh	2688	2688	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effects of recombinant human insulin-like growth factor I administration on the growth_hormone -LRB- gh -RRB- response to GH-releasing hormone in obesity .
10964690	0	growth_hormone	57,71	ghrelin	45,52	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	release|amod|START_ENTITY peptide|nmod|release peptide|appos|END_ENTITY	Central effects of a novel acylated peptide , ghrelin , on growth_hormone release in rats .
11786694	0	growth_hormone	80,94	ghrelin	33,40	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY ligand|nmod|receptor endogenous|acl|ligand Purification|dep|endogenous Purification|nmod|END_ENTITY	Purification and distribution of ghrelin : the natural endogenous ligand for the growth_hormone secretagogue receptor .
11849375	0	growth_hormone	34,48	ghrelin	23,30	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Regulational effect of ghrelin on growth_hormone secretion from perifused rat anterior pituitary cells .
12149581	0	growth_hormone	23,37	ghrelin	4,11	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Rat ghrelin stimulates growth_hormone and prolactin release in the tilapia , Oreochromis_mossambicus .
12624529	0	growth_hormone	34,48	ghrelin	8,15	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY control|nmod|secretion END_ENTITY|nmod|control	Role of ghrelin in the control of growth_hormone secretion in prepubertal rats : interactions with excitatory amino_acids .
12650860	0	growth_hormone	35,49	ghrelin	24,31	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	The role of circulating ghrelin in growth_hormone -LRB- GH -RRB- secretion in freely moving male rats .
12960077	0	growth_hormone	33,47	ghrelin	68,75	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	suppression|nmod|START_ENTITY pulsatility|nsubj|suppression pulsatility|nmod|peptide-6 peptide-6|compound|END_ENTITY	Pattern-dependent suppression of growth_hormone -LRB- GH -RRB- pulsatility by ghrelin and GH-releasing peptide-6 in moderately GH-deficient rats .
14530511	0	growth_hormone	14,28	ghrelin	65,72	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	Evidence|acl:relcl|START_ENTITY exerts|nsubj|Evidence exerts|nmod|production production|compound|END_ENTITY	Evidence that growth_hormone exerts a feedback effect on stomach ghrelin production and secretion .
15087428	0	growth_hormone	33,47	ghrelin	119,126	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY ghrelin|nmod|secretion role|nmod|ghrelin role|dep|regulation regulation|nmod|expression expression|compound|END_ENTITY	The role of pituitary ghrelin in growth_hormone -LRB- GH -RRB- secretion : GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content .
15087428	0	growth_hormone	33,47	ghrelin	22,29	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	The role of pituitary ghrelin in growth_hormone -LRB- GH -RRB- secretion : GH-releasing hormone-dependent regulation of pituitary ghrelin gene expression and peptide content .
15271059	0	growth_hormone	30,44	ghrelin	66,73	growth hormone	ghrelin	14599(Tax:10090)	58991(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY changes|nmod|levels affect|nsubj|changes affect|dobj|expression expression|compound|END_ENTITY	Chronic changes in peripheral growth_hormone levels do not affect ghrelin stomach mRNA expression and serum ghrelin levels in three transgenic mouse models .
15476443	0	growth_hormone	49,63	ghrelin	30,37	growth hormone	ghrelin	2688	59301(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|administration administration|nmod|END_ENTITY	Intravenous administration of ghrelin stimulates growth_hormone secretion in vagotomized patients as well as normal subjects .
15620415	0	growth_hormone	22,36	ghrelin	11,18	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of ghrelin on growth_hormone secretion in vivo in ruminants .
15919752	0	growth_hormone	38,52	ghrelin	11,18	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Endogenous ghrelin regulates episodic growth_hormone -LRB- GH -RRB- secretion by amplifying GH Pulse amplitude : evidence from antagonism of the GH secretagogue-R1a receptor .
16210361	0	growth_hormone	75,89	ghrelin	31,38	growth hormone	ghrelin	443329(Tax:9940)	442996(Tax:9940)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|infusion infusion|nmod|END_ENTITY	Effects of central infusion of ghrelin on food intake and plasma levels of growth_hormone , luteinizing hormone , prolactin , and cortisol secretion in sheep .
16530883	0	growth_hormone	37,51	ghrelin	13,20	growth hormone	ghrelin	14599(Tax:10090)	58991(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|Trp3 Trp3|appos|-RSB- -RSB-|dep|END_ENTITY	-LSB- Trp3 , Arg5 -RSB- - ghrelin -LRB- 1-5 -RRB- stimulates growth_hormone secretion and food intake via growth_hormone_secretagogue _ -LRB- GHS -RRB- _ receptor .
17060681	0	growth_hormone	36,50	ghrelin	19,26	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Central effects of ghrelin on serum growth_hormone and morphology of pituitary somatotropes in rats .
17595213	0	growth_hormone	47,61	ghrelin	11,18	growth hormone	ghrelin	14599(Tax:10090)	58991(Tax:10090)	Gene	Gene	status|amod|START_ENTITY administration|nmod|status administration|compound|END_ENTITY	Effects of ghrelin administration on decreased growth_hormone status in obese animals .
18208550	0	growth_hormone	55,69	ghrelin	96,103	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	circulating|dobj|START_ENTITY baseline|acl|circulating increase|nmod|baseline induced|nsubjpass|increase induced|nmod|END_ENTITY	The pregnancy-induced increase in baseline circulating growth_hormone in rats is not induced by ghrelin .
18719021	0	growth_hormone	35,49	ghrelin	109,116	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	motility|compound|START_ENTITY demarcation|nmod|motility demarcation|acl|using using|dobj|agonist agonist|compound|END_ENTITY	Pharmacological demarcation of the growth_hormone , gut motility and feeding effects of ghrelin using a novel ghrelin receptor agonist .
18719021	0	growth_hormone	35,49	ghrelin	87,94	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	motility|compound|START_ENTITY motility|nmod|END_ENTITY	Pharmacological demarcation of the growth_hormone , gut motility and feeding effects of ghrelin using a novel ghrelin receptor agonist .
20185766	0	growth_hormone	66,80	ghrelin	39,46	growth hormone	ghrelin	14599(Tax:10090)	58991(Tax:10090)	Gene	Gene	responsiveness|amod|START_ENTITY alters|dobj|responsiveness alters|nsubj|reduction reduction|acl|circulating circulating|dobj|END_ENTITY	A postweaning reduction in circulating ghrelin temporarily alters growth_hormone -LRB- GH -RRB- responsiveness to GH-releasing hormone in male mice but does not affect somatic growth .
20437258	0	growth_hormone	71,85	ghrelin	45,52	growth hormone	ghrelin	102171600	100861189	Gene	Gene	release|amod|START_ENTITY Purification|nmod|release Purification|nmod|END_ENTITY	Purification and characterization of caprine ghrelin and its effect on growth_hormone release .
20814072	0	growth_hormone	56,70	ghrelin	14,21	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	axis|nmod|START_ENTITY END_ENTITY|nmod|axis	Importance of ghrelin in hypothalamus-pituitary axis on growth_hormone release during normal pregnancy in the rat .
21081804	0	growth_hormone	23,37	ghrelin	76,83	growth hormone	ghrelin	81668(Tax:10116)	59301(Tax:10116)	Gene	Gene	axis|appos|START_ENTITY Role|nmod|axis Role|dep|IGF-1 IGF-1|nmod|effect effect|nmod|END_ENTITY	Role of hormonal axis , growth_hormone - IGF-1 , in the therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis .
25645493	0	growth_hormone	60,74	ghrelin	9,16	growth hormone	ghrelin	14599(Tax:10090)	58991(Tax:10090)	Gene	Gene	surge|nmod|START_ENTITY required|nmod|surge required|nsubjpass|END_ENTITY	Acylated ghrelin is not required for the surge in pituitary growth_hormone observed in pregnant mice .
12397536	0	growth_hormone	10,24	glucagon-like_peptide-1	50,73	growth hormone	glucagon-like peptide-1	81668(Tax:10116)	24952(Tax:10116)	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Effect of growth_hormone on high plasma levels of glucagon-like_peptide-1 -LRB- GLP-1 -RRB- in hypophysectomized rats .
12846737	0	growth_hormone	57,71	growth-hormone-receptor	14,37	growth hormone	growth-hormone-receptor	2688	2690	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of growth-hormone-receptor gene expression by growth_hormone and pegvisomant in human mesangial cells .
10677054	0	growth_hormone	67,81	growth_hormone	97,111	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Prediction of growth response in prepubertal children treated with growth_hormone for idiopathic growth_hormone deficiency .
10677054	0	growth_hormone	97,111	growth_hormone	67,81	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	Prediction of growth response in prepubertal children treated with growth_hormone for idiopathic growth_hormone deficiency .
12099391	0	growth_hormone	112,126	growth_hormone	63,77	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Responses of bone turnover markers and bone mineral density to growth_hormone therapy in children with isolated growth_hormone deficiency and multiple pituitary_hormone_deficiencies .
12099391	0	growth_hormone	63,77	growth_hormone	112,126	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Responses of bone turnover markers and bone mineral density to growth_hormone therapy in children with isolated growth_hormone deficiency and multiple pituitary_hormone_deficiencies .
14676463	0	growth_hormone	127,141	growth_hormone	62,76	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	Validation of a mathematical model predicting the response to growth_hormone treatment in prepubertal children with idiopathic growth_hormone deficiency .
14676463	0	growth_hormone	62,76	growth_hormone	127,141	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Validation of a mathematical model predicting the response to growth_hormone treatment in prepubertal children with idiopathic growth_hormone deficiency .
15506654	0	growth_hormone	40,54	growth_hormone	75,89	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|treatment treatment|nmod|deficiency deficiency|amod|END_ENTITY	Effects of China-made recombinant human growth_hormone on the treatment of growth_hormone deficiency .
15506654	0	growth_hormone	75,89	growth_hormone	40,54	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY treatment|nmod|deficiency END_ENTITY|nmod|treatment	Effects of China-made recombinant human growth_hormone on the treatment of growth_hormone deficiency .
1876236	0	growth_hormone	10,24	growth_hormone	66,80	growth hormone	growth hormone	2688	2688	Gene	Gene	inhibits|advmod|START_ENTITY inhibits|dobj|secretion secretion|amod|END_ENTITY	Exogenous growth_hormone inhibits bovine but not murine pituitary growth_hormone secretion in vitro : evidence for a direct feedback of growth_hormone on the pituitary .
1876236	0	growth_hormone	66,80	growth_hormone	10,24	growth hormone	growth hormone	2688	2688	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|advmod|END_ENTITY	Exogenous growth_hormone inhibits bovine but not murine pituitary growth_hormone secretion in vitro : evidence for a direct feedback of growth_hormone on the pituitary .
188861	0	growth_hormone	44,58	growth_hormone	62,76	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Collaborative study of the effects of human growth_hormone in growth_hormone deficiency : IV .
188861	0	growth_hormone	62,76	growth_hormone	44,58	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Collaborative study of the effects of human growth_hormone in growth_hormone deficiency : IV .
1916657	0	growth_hormone	40,54	growth_hormone	73,87	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Comparative study of biosynthetic human growth_hormone immunogenicity in growth_hormone deficient children .
1916657	0	growth_hormone	73,87	growth_hormone	40,54	growth hormone	growth hormone	2688	2688	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Comparative study of biosynthetic human growth_hormone immunogenicity in growth_hormone deficient children .
19320648	0	growth_hormone	59,73	growth_hormone	83,97	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	The value of the oral glucose tolerance test , random serum growth_hormone and mean growth_hormone levels in assessing the postoperative outcome of patients with acromegaly .
19320648	0	growth_hormone	83,97	growth_hormone	59,73	growth hormone	growth hormone	2688	2688	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|dobj|levels	The value of the oral glucose tolerance test , random serum growth_hormone and mean growth_hormone levels in assessing the postoperative outcome of patients with acromegaly .
2198432	0	growth_hormone	50,64	growth_hormone	76,90	growth hormone	growth hormone	2688	2688	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	The growth_hormone clamp technique : inhibition of growth_hormone release by growth_hormone occurs independently of free fatty_acids .
2198432	0	growth_hormone	76,90	growth_hormone	50,64	growth hormone	growth hormone	2688	2688	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	The growth_hormone clamp technique : inhibition of growth_hormone release by growth_hormone occurs independently of free fatty_acids .
22006181	0	growth_hormone	62,76	growth_hormone	80,94	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Impact of overweight on effectiveness of treatment with human growth_hormone in growth_hormone deficient children : analysis of German KIGS data .
22006181	0	growth_hormone	80,94	growth_hormone	62,76	growth hormone	growth hormone	2688	2688	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Impact of overweight on effectiveness of treatment with human growth_hormone in growth_hormone deficient children : analysis of German KIGS data .
24686034	0	growth_hormone	119,133	growth_hormone	54,68	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|compound|START_ENTITY END_ENTITY|nmod|deficiency	Reference curve for the first-year growth response to growth_hormone treatment in prepubertal children with idiopathic growth_hormone deficiency : validation of the KIGS first-year growth response curve using the Belgian Register for the Study of Growth and Puberty Problems .
24686034	0	growth_hormone	54,68	growth_hormone	119,133	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Reference curve for the first-year growth response to growth_hormone treatment in prepubertal children with idiopathic growth_hormone deficiency : validation of the KIGS first-year growth response curve using the Belgian Register for the Study of Growth and Puberty Problems .
2613191	0	growth_hormone	36,50	growth_hormone	62,76	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Response of serine antiproteases to growth_hormone therapy in growth_hormone deficient children .
2613191	0	growth_hormone	62,76	growth_hormone	36,50	growth hormone	growth hormone	2688	2688	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Response of serine antiproteases to growth_hormone therapy in growth_hormone deficient children .
26188227	0	growth_hormone	75,89	growth_hormone	93,107	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Auxologic parameters and response to 2-year therapy with recombinant human growth_hormone in growth_hormone deficient children with an ectopic posterior pituitary .
26188227	0	growth_hormone	75,89	growth_hormone	93,107	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Auxologic parameters and response to 2-year therapy with recombinant human growth_hormone in growth_hormone deficient children with an ectopic posterior pituitary .
26188227	0	growth_hormone	93,107	growth_hormone	75,89	growth hormone	growth hormone	2688	2688	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Auxologic parameters and response to 2-year therapy with recombinant human growth_hormone in growth_hormone deficient children with an ectopic posterior pituitary .
26188227	0	growth_hormone	93,107	growth_hormone	75,89	growth hormone	growth hormone	2688	2688	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Auxologic parameters and response to 2-year therapy with recombinant human growth_hormone in growth_hormone deficient children with an ectopic posterior pituitary .
3513479	0	growth_hormone	43,57	growth_hormone	61,75	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Daily subcutaneous administration of human growth_hormone in growth_hormone deficient children .
3513479	0	growth_hormone	61,75	growth_hormone	43,57	growth hormone	growth hormone	2688	2688	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Daily subcutaneous administration of human growth_hormone in growth_hormone deficient children .
3662594	0	growth_hormone	47,61	growth_hormone	65,79	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Single dose and pulsatile treatment with human growth_hormone in growth_hormone deficiency .
3662594	0	growth_hormone	65,79	growth_hormone	47,61	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Single dose and pulsatile treatment with human growth_hormone in growth_hormone deficiency .
3928474	0	growth_hormone	7,21	growth_hormone	85,99	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Plasma growth_hormone response to synthetic GH-RH1-44 in 52 children and adults with growth_hormone deficiency of various etiologies .
3928474	0	growth_hormone	85,99	growth_hormone	7,21	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Plasma growth_hormone response to synthetic GH-RH1-44 in 52 children and adults with growth_hormone deficiency of various etiologies .
6240568	0	growth_hormone	15,29	growth_hormone	51,65	growth hormone	growth hormone	2688	2688	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Stimulation of growth_hormone secretion with human growth_hormone releasing factors -LRB- GRF1-44 , GRF1-40 , GRF1-29 -RRB- in normal subjects .
6240568	0	growth_hormone	51,65	growth_hormone	15,29	growth hormone	growth hormone	2688	2688	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Stimulation of growth_hormone secretion with human growth_hormone releasing factors -LRB- GRF1-44 , GRF1-40 , GRF1-29 -RRB- in normal subjects .
6424103	0	growth_hormone	126,140	growth_hormone	32,46	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|compound|START_ENTITY stimulates|nmod|deficiency stimulates|dobj|secretion secretion|compound|END_ENTITY	Synthetic hpGRF 1-40 stimulates growth_hormone and inhibits prolactin secretion in normal children and children with isolated growth_hormone deficiency .
6424103	0	growth_hormone	32,46	growth_hormone	126,140	growth hormone	growth hormone	2688	2688	Gene	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nmod|deficiency deficiency|compound|END_ENTITY	Synthetic hpGRF 1-40 stimulates growth_hormone and inhibits prolactin secretion in normal children and children with isolated growth_hormone deficiency .
6439436	0	growth_hormone	22,36	growth_hormone	75,89	growth hormone	growth hormone	2688	2688	Gene	Gene	secretion|amod|START_ENTITY secretion|acl|induced induced|nmod|END_ENTITY	Oral glucose inhibits growth_hormone secretion induced by human pancreatic growth_hormone releasing factor 1-44 in normal man .
6439436	0	growth_hormone	75,89	growth_hormone	22,36	growth hormone	growth hormone	2688	2688	Gene	Gene	induced|nmod|START_ENTITY secretion|acl|induced secretion|amod|END_ENTITY	Oral glucose inhibits growth_hormone secretion induced by human pancreatic growth_hormone releasing factor 1-44 in normal man .
6681687	0	growth_hormone	27,41	growth_hormone	90,104	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Imitation of normal plasma growth_hormone profile by subcutaneous administration of human growth_hormone to growth_hormone deficient children .
6681687	0	growth_hormone	90,104	growth_hormone	27,41	growth hormone	growth hormone	2688	2688	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Imitation of normal plasma growth_hormone profile by subcutaneous administration of human growth_hormone to growth_hormone deficient children .
7430886	0	growth_hormone	17,31	growth_hormone	56,70	growth hormone	growth hormone	2688	81668(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of human growth_hormone on the secretion of rat growth_hormone .
7430886	0	growth_hormone	56,70	growth_hormone	17,31	growth hormone	growth hormone	81668(Tax:10116)	2688	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of human growth_hormone on the secretion of rat growth_hormone .
7869213	0	growth_hormone	12,26	growth_hormone	52,66	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Response to growth_hormone therapy in patients with growth_hormone deficiency who at birth were small or appropriate in size for gestational age .
7869213	0	growth_hormone	52,66	growth_hormone	12,26	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Response to growth_hormone therapy in patients with growth_hormone deficiency who at birth were small or appropriate in size for gestational age .
8112715	0	growth_hormone	39,53	growth_hormone	64,78	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	The effect of exogenous and endogenous growth_hormone on plasma growth_hormone binding activity in prepubertal children .
8112715	0	growth_hormone	64,78	growth_hormone	39,53	growth hormone	growth hormone	2688	2688	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	The effect of exogenous and endogenous growth_hormone on plasma growth_hormone binding activity in prepubertal children .
8325951	0	growth_hormone	32,46	growth_hormone	64,78	growth hormone	growth hormone	2688	2688	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|END_ENTITY	The effect of recombinant human growth_hormone on regulation of growth_hormone secretion and blood glucose in insulin-dependent_diabetes .
8325951	0	growth_hormone	64,78	growth_hormone	32,46	growth hormone	growth hormone	2688	2688	Gene	Gene	secretion|amod|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of recombinant human growth_hormone on regulation of growth_hormone secretion and blood glucose in insulin-dependent_diabetes .
8488802	0	growth_hormone	114,128	growth_hormone	21,35	growth hormone	growth hormone	2688	2688	Gene	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	The value of urinary growth_hormone determination for assessment of growth_hormone deficiency and compliance with growth_hormone therapy .
8488802	0	growth_hormone	21,35	growth_hormone	114,128	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	The value of urinary growth_hormone determination for assessment of growth_hormone deficiency and compliance with growth_hormone therapy .
8522274	0	growth_hormone	18,32	growth_hormone	91,105	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|treatment treatment|amod|END_ENTITY	Nocturnal urinary growth_hormone excretion in growth_hormone-deficient children on and off growth_hormone treatment .
8522274	0	growth_hormone	91,105	growth_hormone	18,32	growth hormone	growth hormone	2688	2688	Gene	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Nocturnal urinary growth_hormone excretion in growth_hormone-deficient children on and off growth_hormone treatment .
8590960	0	growth_hormone	20,34	growth_hormone	64,78	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of exogenous growth_hormone administration on endogenous growth_hormone secretion induced by a met-enkephalin analog .
8590960	0	growth_hormone	64,78	growth_hormone	20,34	growth hormone	growth hormone	2688	2688	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effect of exogenous growth_hormone administration on endogenous growth_hormone secretion induced by a met-enkephalin analog .
8787937	0	growth_hormone	45,59	growth_hormone	94,108	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|treatment treatment|amod|END_ENTITY	Body composition and tissue distributions in growth_hormone deficient adults before and after growth_hormone treatment .
8787937	0	growth_hormone	94,108	growth_hormone	45,59	growth hormone	growth hormone	2688	2688	Gene	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Body composition and tissue distributions in growth_hormone deficient adults before and after growth_hormone treatment .
892705	0	growth_hormone	30,44	growth_hormone	53,67	growth hormone	growth hormone	2688	2688	Gene	Gene	Conversion|nmod|START_ENTITY END_ENTITY|nsubj|Conversion	Conversion of monomeric human growth_hormone and big growth_hormone into different molecular weight forms in vitro and after injection into humans .
892705	0	growth_hormone	53,67	growth_hormone	30,44	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion of monomeric human growth_hormone and big growth_hormone into different molecular weight forms in vitro and after injection into humans .
9475305	0	growth_hormone	132,146	growth_hormone	59,73	growth hormone	growth hormone	2688	2688	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency END_ENTITY|nmod|patients	Pharmacokinetics and pharmacodynamics of recombinant human growth_hormone by subcutaneous jet - or needle-injection in patients with growth_hormone deficiency .
9475305	0	growth_hormone	59,73	growth_hormone	132,146	growth hormone	growth hormone	2688	2688	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Pharmacokinetics and pharmacodynamics of recombinant human growth_hormone by subcutaneous jet - or needle-injection in patients with growth_hormone deficiency .
1474343	0	growth_hormone	33,47	growth_hormone-releasing_factor	141,172	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	START_ENTITY|nmod|delivery delivery|nmod|END_ENTITY	Restoration of juvenile baseline growth_hormone secretion with preservation of the ultradian growth_hormone rhythm by continuous delivery of growth_hormone-releasing_factor .
1474343	0	growth_hormone	93,107	growth_hormone-releasing_factor	141,172	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	rhythm|compound|START_ENTITY preservation|nmod|rhythm growth_hormone|nmod|preservation growth_hormone|nmod|delivery delivery|nmod|END_ENTITY	Restoration of juvenile baseline growth_hormone secretion with preservation of the ultradian growth_hormone rhythm by continuous delivery of growth_hormone-releasing_factor .
15367266	0	growth_hormone	78,92	growth_hormone-releasing_factor	21,52	growth hormone	growth hormone-releasing factor	102406287	281191(Tax:9913)	Gene	Gene	administration|nmod|START_ENTITY administration|amod|END_ENTITY	Effects of long-term growth_hormone-releasing_factor administration on plasma growth_hormone , luteinizing hormone and progesterone profiles in growing female buffaloes -LRB- Bubalus_bubalis -RRB- .
23015655	0	growth_hormone	86,100	growth_hormone-releasing_factor	23,54	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	secretion|compound|START_ENTITY subjects|nmod|secretion END_ENTITY|nmod|subjects	Metabolic effects of a growth_hormone-releasing_factor in obese subjects with reduced growth_hormone secretion : a randomized controlled trial .
3020850	0	growth_hormone	91,105	growth_hormone-releasing_factor	155,186	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	responsiveness|amod|START_ENTITY re-instates|dobj|responsiveness re-instates|nmod|administration administration|nmod|END_ENTITY	Potentiation of cholinergic tone by pyridostigmine_bromide re-instates and potentiates the growth_hormone responsiveness to intermittent administration of growth_hormone-releasing_factor in man .
3085999	0	growth_hormone	23,37	growth_hormone-releasing_factor	55,86	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	START_ENTITY|dobj|response response|nmod|hypoglycaemia hypoglycaemia|amod|END_ENTITY	A divergence of plasma growth_hormone response between growth_hormone-releasing_factor and insulin-induced hypoglycaemia among middle-aged healthy male subjects .
3131855	0	growth_hormone	12,26	growth_hormone-releasing_factor	38,69	growth hormone	growth hormone-releasing factor	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	-LSB- Control of growth_hormone release by growth_hormone-releasing_factor and prostaglandin_E2 in a system of perfused rat anterior pituitary cells -RSB- .
3160962	0	growth_hormone	23,37	growth_hormone-releasing_factor	101,132	growth hormone	growth hormone-releasing factor	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY mediated|nsubjpass|secretion mediated|nmod|END_ENTITY	Pituitary secretion of growth_hormone in response to opioid peptides and opiates is mediated through growth_hormone-releasing_factor .
3919137	0	growth_hormone	131,145	growth_hormone-releasing_factor	45,76	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	concentrations|nmod|START_ENTITY sustains|dobj|concentrations sustains|nsubj|Administration Administration|nmod|END_ENTITY	Administration of synthetic human pancreatic growth_hormone-releasing_factor for five days sustains raised serum concentrations of growth_hormone in steers .
3930225	0	growth_hormone	7,21	growth_hormone-releasing_factor	64,95	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	responses|amod|START_ENTITY responses|nmod|infusion infusion|amod|END_ENTITY	Plasma growth_hormone and somatomedin-C responses to continuous growth_hormone-releasing_factor infusion in normal adult men .
6409919	0	growth_hormone	84,98	growth_hormone-releasing_factor	25,56	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Synthetic human pancreas growth_hormone-releasing_factor -LRB- hpGRF1-44-NH2 -RRB- stimulates growth_hormone secretion in normal men .
6415487	0	growth_hormone	30,44	growth_hormone-releasing_factor	64,95	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of growth_hormone gene expression by growth_hormone-releasing_factor .
7587172	0	growth_hormone	107,121	growth_hormone-releasing_factor	158,189	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	concentration|amod|START_ENTITY circulating|dobj|concentration circulating|nmod|administration administration|amod|END_ENTITY	Effect of dietary energy intake and exogenous porcine growth_hormone administration on circulating porcine growth_hormone concentration and response to human growth_hormone-releasing_factor administration in growing swine .
7587172	0	growth_hormone	54,68	growth_hormone-releasing_factor	158,189	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	administration|amod|START_ENTITY porcine|dobj|administration porcine|advcl|circulating circulating|nmod|administration administration|amod|END_ENTITY	Effect of dietary energy intake and exogenous porcine growth_hormone administration on circulating porcine growth_hormone concentration and response to human growth_hormone-releasing_factor administration in growing swine .
9303474	0	growth_hormone	34,48	growth_hormone-releasing_factor	69,100	growth hormone	growth hormone-releasing factor	2688	2691	Gene	Gene	role|nmod|START_ENTITY Evidence|nmod|role Evidence|dep|effects effects|nmod|END_ENTITY	Evidence for a mammogenic role of growth_hormone in ewes : effects of growth_hormone-releasing_factor during artificial induction of lactation .
10521035	0	growth_hormone	64,78	growth_hormone-releasing_hormone	91,123	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY performance|nmod|response Predicting|dobj|performance Predicting|nmod|END_ENTITY	Predicting bull growth performance and carcass composition from growth_hormone response to growth_hormone-releasing_hormone .
10594518	0	growth_hormone	125,139	growth_hormone-releasing_hormone	33,65	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The relative roles of continuous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- and intermittent somatostatin -LRB- 1-14 -RRB- -LRB- SS -RRB- in growth_hormone -LRB- GH -RRB- pulse generation : studies in normal and post cranial irradiated individuals .
11291426	0	growth_hormone	79,93	growth_hormone-releasing_hormone	16,48	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Contribution of growth_hormone-releasing_hormone and somatostatin to decreased growth_hormone secretion in elderly men .
11882517	0	growth_hormone	10,24	growth_hormone-releasing_hormone	55,87	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|compound|START_ENTITY persists|nsubj|secretion persists|nmod|resistance resistance|amod|END_ENTITY	Pulsatile growth_hormone secretion persists in genetic growth_hormone-releasing_hormone resistance .
12413983	0	growth_hormone	53,67	growth_hormone-releasing_hormone	80,112	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|compound|START_ENTITY blockade|nmod|response Effect|nmod|blockade Effect|acl|END_ENTITY	Effect of the opioid blockade on the feeding-induced growth_hormone response to growth_hormone-releasing_hormone in women with polycystic_ovary_syndrome .
12740741	0	growth_hormone	102,116	growth_hormone-releasing_hormone	26,58	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|nmod|START_ENTITY Involvement|nmod|response Involvement|nmod|END_ENTITY	Involvement of endogenous growth_hormone-releasing_hormone -LRB- GHRH -RRB- in the exercise-related response of growth_hormone .
1311892	0	growth_hormone	30,44	growth_hormone-releasing_hormone	57,89	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY atenolol|nmod|response effect|nmod|atenolol effect|acl|END_ENTITY	The effect of atenolol on the growth_hormone response to growth_hormone-releasing_hormone in obese children .
1347904	0	growth_hormone	88,102	growth_hormone-releasing_hormone	35,67	growth hormone	growth hormone-releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of passive immunization of growth_hormone-releasing_hormone and somatostatin on growth_hormone secretion under conditions of high somatostatin tone .
1385023	0	growth_hormone	23,37	growth_hormone-releasing_hormone	59,91	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY reinstates|dobj|response reinstates|nmod|administration administration|amod|END_ENTITY	Galanin reinstates the growth_hormone response to repeated growth_hormone-releasing_hormone administration in man .
1499577	0	growth_hormone	102,116	growth_hormone-releasing_hormone	20,52	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	deficiency|compound|START_ENTITY value|nmod|deficiency value|nmod|test test|amod|END_ENTITY	Diagnostic value of growth_hormone-releasing_hormone test in children and adolescents with idiopathic growth_hormone deficiency .
15155578	0	growth_hormone	101,115	growth_hormone-releasing_hormone	38,70	growth hormone	growth hormone-releasing hormone	14599(Tax:10090)	14601(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY model|nmod|deficiency mouse|dep|model mouse|nmod|ablation ablation|nmod|gene gene|amod|END_ENTITY	A mouse with targeted ablation of the growth_hormone-releasing_hormone gene : a new model of isolated growth_hormone deficiency .
15240610	0	growth_hormone	16,30	growth_hormone-releasing_hormone	189,221	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY Augmentation|nmod|secretion Augmentation|dep|evidence evidence|nmod|increase increase|nmod|secretion secretion|nmod|END_ENTITY	Augmentation of growth_hormone secretion after testosterone treatment in boys with constitutional delay of growth and adolescence : evidence against an increase in hypothalamic secretion of growth_hormone-releasing_hormone .
1865077	0	growth_hormone	19,33	growth_hormone-releasing_hormone	46,78	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY differences|nmod|response differences|nmod|END_ENTITY	Sex differences in growth_hormone response to growth_hormone-releasing_hormone .
1983729	0	growth_hormone	70,84	growth_hormone-releasing_hormone	26,58	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY modulation|nmod|secretion modulation|nmod|effects effects|amod|END_ENTITY	Cholinergic modulation of growth_hormone-releasing_hormone effects on growth_hormone secretion in dementia .
19912928	0	growth_hormone	112,126	growth_hormone-releasing_hormone	8,40	growth hormone	growth hormone-releasing hormone	14599(Tax:10090)	14601(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Altered growth_hormone-releasing_hormone mRNA expression in transgenic_mice with excess_or_deficient endogenous growth_hormone .
2023538	0	growth_hormone	47,61	growth_hormone-releasing_hormone	74,106	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY modulating|dobj|response modulating|advcl|END_ENTITY	The role of cholinergic tone in modulating the growth_hormone response to growth_hormone-releasing_hormone in normal man .
2106092	0	growth_hormone	151,165	growth_hormone-releasing_hormone	26,58	growth hormone	growth hormone-releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY reveals|nmod|secretion reveals|nsubj|Depletion Depletion|nmod|END_ENTITY	Depletion of hypothalamic growth_hormone-releasing_hormone by neonatal monosodium_glutamate treatment reveals an inhibitory effect of betamethasone on growth_hormone secretion in adult rats .
2107653	0	growth_hormone	38,52	growth_hormone-releasing_hormone	65,97	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY cortisone_acetate|nmod|response effects|nmod|cortisone_acetate effects|acl|END_ENTITY	Acute effects of cortisone_acetate on growth_hormone response to growth_hormone-releasing_hormone in normal adult subjects .
2118535	0	growth_hormone	110,124	growth_hormone-releasing_hormone	66,98	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Pyridostigmine blocks the inhibitory effect of glucocorticoids on growth_hormone-releasing_hormone stimulated growth_hormone secretion in normal man .
2118536	0	growth_hormone	10,24	growth_hormone-releasing_hormone	94,126	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|compound|START_ENTITY secretion|dep|effects effects|nmod|infusion infusion|amod|END_ENTITY	Pulsatile growth_hormone secretion in patients with acromegaly and normal men : the effects of growth_hormone-releasing_hormone infusion .
2463192	0	growth_hormone	14,28	growth_hormone-releasing_hormone	138,170	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY Regulation|nmod|secretion Regulation|dep|interactions interactions|acl|involved involved|nmod|activation activation|acl|induced induced|nmod|END_ENTITY	Regulation of growth_hormone secretion and cyclic_AMP metabolism in ovine pituitary cells : interactions involved in activation induced by growth_hormone-releasing_hormone and phorbol_esters .
2506218	0	growth_hormone	83,97	growth_hormone-releasing_hormone	11,43	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY restores|dobj|response restores|nsubj|administration administration|amod|END_ENTITY	Repetitive growth_hormone-releasing_hormone administration restores the attenuated growth_hormone -LRB- GH -RRB- response to GH-releasing hormone testing in normal aging .
2546369	0	growth_hormone	102,116	growth_hormone-releasing_hormone	31,63	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY augment|dobj|secretion infusions|ccomp|augment infusions|nsubj|END_ENTITY	Use of continuous subcutaneous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- infusions to augment growth_hormone secretion and to promote growth .
3100110	0	growth_hormone	124,138	growth_hormone-releasing_hormone	58,90	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	effect|nmod|START_ENTITY evidence|nmod|effect pretreatment|dep|evidence pretreatment|nmod|END_ENTITY	Growth_hormone pretreatment in man blocks the response to growth_hormone-releasing_hormone ; evidence for a direct effect of growth_hormone .
3114305	0	growth_hormone	26,40	growth_hormone-releasing_hormone	53,85	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY sex|nmod|response Effects|nmod|sex Effects|acl|END_ENTITY	Effects of sex and age on growth_hormone response to growth_hormone-releasing_hormone in healthy individuals .
3116798	0	growth_hormone	18,32	growth_hormone-releasing_hormone	45,77	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY difference|nmod|response difference|acl|END_ENTITY	Sex difference in growth_hormone response to growth_hormone-releasing_hormone between pubertal tall girls and boys .
3117450	0	growth_hormone	77,91	growth_hormone-releasing_hormone	104,136	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY affect|dobj|response affect|nmod|END_ENTITY	Stilboestrol pretreatment of children with short stature does not affect the growth_hormone response to growth_hormone-releasing_hormone .
3135287	0	growth_hormone	62,76	growth_hormone-releasing_hormone	11,43	growth hormone	growth hormone-releasing hormone	2688	281191(Tax:9913)	Gene	Gene	release|nmod|START_ENTITY induce|dobj|release induce|nsubj|Analogs Analogs|nmod|END_ENTITY	Analogs of growth_hormone-releasing_hormone induce release of growth_hormone in the bovine .
3144116	0	growth_hormone	89,103	growth_hormone-releasing_hormone	27,59	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	dysfunction|amod|START_ENTITY index|nmod|dysfunction response|nmod|index response|nmod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- hp GHRH1-44 -RRB- as an index of growth_hormone secretory dysfunction after prophylactic cranial irradiation for acute_lymphoblastic_leukemia -LRB- 24 grays -RRB- .
3145297	0	growth_hormone	72,86	growth_hormone-releasing_hormone	112,144	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY administration|nmod|response influence|nmod|administration influence|nmod|END_ENTITY	Inhibitory influence of thyrotropin_releasing_hormone administration on growth_hormone response to low doses of growth_hormone-releasing_hormone in normal man .
7486404	0	growth_hormone	91,105	growth_hormone-releasing_hormone	43,75	growth hormone	growth hormone-releasing hormone	443329(Tax:9940)	780526(Tax:9940)	Gene	Gene	release|amod|START_ENTITY Effects|nmod|release Effects|nmod|infusion infusion|nmod|stimulation stimulation|amod|END_ENTITY	Effects of short-term cortisol infusion on growth_hormone-releasing_hormone stimulation of growth_hormone release in sheep .
8112716	0	growth_hormone	27,41	growth_hormone-releasing_hormone	96,128	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	levels|compound|START_ENTITY Variability|nmod|levels Variability|dep|specificity specificity|nmod|stimulation stimulation|amod|END_ENTITY	Variability of serum human growth_hormone levels in different commercial assays : specificity of growth_hormone-releasing_hormone stimulation .
8187302	0	growth_hormone	91,105	growth_hormone-releasing_hormone	109,141	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	responses|nmod|START_ENTITY enhances|dobj|responses enhances|xcomp|END_ENTITY	Octreotide administration , under particular temporal conditions , enhances the responses of growth_hormone to growth_hormone-releasing_hormone in normal subjects .
8255393	0	growth_hormone	105,119	growth_hormone-releasing_hormone	31,63	growth hormone	growth hormone-releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY mechanism|nmod|levels decrease|dep|mechanism decrease|nmod|expression expression|amod|END_ENTITY	Obesity-associated decrease in growth_hormone-releasing_hormone gene expression : a mechanism for reduced growth_hormone mRNA levels in genetically obese Zucker rats .
8258646	0	growth_hormone	19,33	growth_hormone-releasing_hormone	46,78	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY Variability|nmod|response Variability|dep|END_ENTITY	Variability in the growth_hormone response to growth_hormone-releasing_hormone alone or combined with pyridostigmine in type 1 diabetic patients .
8370132	0	growth_hormone	21,35	growth_hormone-releasing_hormone	78,110	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nmod|pathways pathways|nmod|END_ENTITY	Melatonin stimulates growth_hormone secretion through pathways other than the growth_hormone-releasing_hormone .
8370135	0	growth_hormone	75,89	growth_hormone-releasing_hormone	102,134	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Protein intake during aggressive calorie restriction in obesity determines growth_hormone response to growth_hormone-releasing_hormone after weight_loss .
8622602	0	growth_hormone	49,63	growth_hormone-releasing_hormone	76,108	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Long-term administration of acipimox potentiates growth_hormone response to growth_hormone-releasing_hormone by decreasing serum free fatty_acid in obesity .
8921823	0	growth_hormone	42,56	growth_hormone-releasing_hormone	100,132	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	administration|nmod|START_ENTITY inhibits|nsubj|administration inhibits|ccomp|responsiveness responsiveness|xcomp|END_ENTITY	Acute administration of recombinant human growth_hormone inhibits the somatotrope responsiveness to growth_hormone-releasing_hormone in childhood .
8980159	0	growth_hormone	23,37	growth_hormone-releasing_hormone	67,99	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|stimulation stimulation|nmod|plus plus|amod|END_ENTITY	Reproducibility of the growth_hormone response to stimulation with growth_hormone-releasing_hormone plus arginine during lifespan .
9086339	0	growth_hormone	33,47	growth_hormone-releasing_hormone	74,106	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|compound|START_ENTITY valerate|nmod|response valerate|nmod|stimulation stimulation|amod|END_ENTITY	Effects of estradiol valerate on growth_hormone and prolactin response to growth_hormone-releasing_hormone stimulation in pre - and postmenopausal women .
9231053	0	growth_hormone	31,45	growth_hormone-releasing_hormone	62,94	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	deficiency|compound|START_ENTITY Treatment|nmod|deficiency Treatment|nmod|END_ENTITY	Treatment of radiation-induced growth_hormone deficiency with growth_hormone-releasing_hormone .
9494699	0	growth_hormone	59,73	growth_hormone-releasing_hormone	86,118	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY agonists|nmod|response Effects|nmod|agonists Effects|acl|END_ENTITY	Effects of beta-adrenergic agonists and antagonists on the growth_hormone response to growth_hormone-releasing_hormone in anorexia_nervosa .
9930632	0	growth_hormone	198,212	growth_hormone-releasing_hormone	136,168	growth hormone	growth hormone-releasing hormone	2688	2691	Gene	Gene	central|xcomp|START_ENTITY central|nmod|resistance resistance|amod|END_ENTITY	Growth_hormone-insulin-like_growth_factor-I_axis in adult insulin-dependent diabetic patients : evidence for central hypersensitivity to growth_hormone-releasing_hormone and peripheral resistance to growth_hormone .
11404009	0	growth_hormone	97,111	growth_hormone_receptor	31,54	growth hormone	growth hormone receptor	2688	2690	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of a teleost growth_hormone_receptor and its functional interaction with human growth_hormone .
1296432	0	growth_hormone	82,96	growth_hormone_releasing_factor	47,78	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Defective response of plasma growth_hormone to growth_hormone_releasing_factor in growth_hormone deficient children .
1678494	0	growth_hormone	12,26	growth_hormone_releasing_factor	45,76	growth hormone	growth hormone releasing factor	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	Dynamics|nmod|START_ENTITY responsiveness|nsubj|Dynamics responsiveness|xcomp|END_ENTITY	Dynamics of growth_hormone responsiveness to growth_hormone_releasing_factor in aging rats : peripheral and central influences .
2678528	0	growth_hormone	35,49	growth_hormone_releasing_factor	66,97	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	secretion|amod|START_ENTITY stimulating|dobj|secretion stimulating|advcl|using using|dobj|-RSB- -RSB-|compound|END_ENTITY	-LSB- Various mechanisms of stimulating growth_hormone secretion using growth_hormone_releasing_factor and insulin-induced hypoglycemia -RSB- .
2856651	0	growth_hormone	65,79	growth_hormone_releasing_factor	6,37	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	START_ENTITY|nsubj|effects effects|compound|END_ENTITY	Human growth_hormone_releasing_factor infusion effects on plasma growth_hormone in affective_disorder patients and normal controls .
2858817	0	growth_hormone	58,72	growth_hormone_releasing_factor	23,54	growth hormone	growth hormone releasing factor	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	release|amod|START_ENTITY effects|nmod|release effects|nmod|END_ENTITY	Independent effects of growth_hormone_releasing_factor on growth_hormone release and gene transcription .
2860126	0	growth_hormone	10,24	growth_hormone_releasing_factor	95,126	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Pulsatile growth_hormone secretion in normal man during a continuous 24-hour infusion of human growth_hormone_releasing_factor -LRB- 1-40 -RRB- .
2877535	0	growth_hormone	99,113	growth_hormone_releasing_factor	42,73	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	secretion|amod|START_ENTITY NH2|nmod|secretion NH2|compound|END_ENTITY	The effects of intranasal insufflation of growth_hormone_releasing_factor analogue GRF_1-29 NH2 on growth_hormone secretion in children with short_stature .
2888167	0	growth_hormone	14,28	growth_hormone_releasing_factor	90,121	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	secretion|amod|START_ENTITY Regulation|nmod|secretion Regulation|dep|interactions interactions|nmod|END_ENTITY	Regulation of growth_hormone secretion from human fetal pituitaries : interactions between growth_hormone_releasing_factor and somatostatin .
3082645	0	growth_hormone	89,103	growth_hormone_releasing_factor	16,47	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	secretion|compound|START_ENTITY dose|nmod|secretion dose|nsubj|END_ENTITY	Synthetic human growth_hormone_releasing_factor -LRB- h-GRF-I-44-NH2 -RRB- dose response effect on growth_hormone and prolactin secretion in healthy adult men .
3118426	0	growth_hormone	78,92	growth_hormone_releasing_factor	12,43	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	-RSB-|amod|START_ENTITY reserve|nmod|-RSB- test|nmod|reserve -LSB-|nmod|test -LSB-|dobj|use use|nmod|END_ENTITY	-LSB- The use of growth_hormone_releasing_factor as a test of pituitary reserve of growth_hormone -RSB- .
3125487	0	growth_hormone	26,40	growth_hormone_releasing_factor	98,129	growth hormone	growth hormone releasing factor	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	testosterone|nmod|START_ENTITY Effect|nmod|testosterone secretion|nsubj|Effect secretion|nmod|infusion infusion|nmod|END_ENTITY	Effect of testosterone on growth_hormone secretion in female rats during a continuous infusion of growth_hormone_releasing_factor .
4350846	0	growth_hormone	57,71	growth_hormone_releasing_factor	22,53	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effects of a purified growth_hormone_releasing_factor on growth_hormone secretion and pituitary cyclic nucleotide content .
6405935	0	growth_hormone	17,31	growth_hormone_releasing_factor	72,103	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	Abnormalities|nmod|START_ENTITY release|nsubj|Abnormalities release|nmod|END_ENTITY	Abnormalities of growth_hormone release in response to human pancreatic growth_hormone_releasing_factor -LRB- GRF _ -LRB- 1-44 -RRB- -RRB- in acromegaly and hypopituitarism .
6423920	0	growth_hormone	76,90	growth_hormone_releasing_factor	27,58	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Synthetic human pancreatic growth_hormone_releasing_factor -LRB- GRF -RRB- stimulates growth_hormone secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
6424979	0	growth_hormone	36,50	growth_hormone_releasing_factor	80,111	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	response|amod|START_ENTITY glucose|nmod|response glucose|nmod|END_ENTITY	The effect of plasma glucose on the growth_hormone response to human pancreatic growth_hormone_releasing_factor in normal subjects .
6429198	0	growth_hormone	7,21	growth_hormone_releasing_factor	74,105	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	START_ENTITY|nmod|infusions infusions|nmod|END_ENTITY	Plasma growth_hormone responses to constant infusions of human pancreatic growth_hormone_releasing_factor .
6442698	0	growth_hormone	7,21	growth_hormone_releasing_factor	65,96	growth hormone	growth hormone releasing factor	2688	2691	Gene	Gene	START_ENTITY|nmod|administrations administrations|nmod|END_ENTITY	Plasma growth_hormone responses to repetitive administrations of growth_hormone_releasing_factor in patients with pituitary_dwarfism .
12201831	0	growth_hormone	9,23	growth_hormone_releasing_hormone	120,152	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	determination|compound|START_ENTITY sufficient|nsubj|determination sufficient|xcomp|using using|dobj|END_ENTITY	A single growth_hormone -LRB- GH -RRB- determination is sufficient for the diagnosis of GH-deficiency in adult patients using the growth_hormone_releasing_hormone plus growth_hormone releasing peptide-6 test .
1362733	0	growth_hormone	141,155	growth_hormone_releasing_hormone	184,216	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|END_ENTITY	Growth_hormone therapy in normal short children induces a transitory decrease in plasma growth_hormone_releasing_hormone levels and in human growth_hormone responsiveness to exogenous growth_hormone_releasing_hormone .
1397474	0	growth_hormone	82,96	growth_hormone_releasing_hormone	39,71	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	action|nmod|START_ENTITY action|amod|END_ENTITY	Role of prostaglandin_E2 -LRB- PGE2 -RRB- in the growth_hormone_releasing_hormone action on growth_hormone , insulin and C-peptide in normal men .
14506689	0	growth_hormone	36,50	growth_hormone_releasing_hormone	114,146	growth hormone	growth hormone releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	organelles|appos|START_ENTITY Dynamics|nmod|organelles caused|nsubj|Dynamics caused|nmod|END_ENTITY	Dynamics of subcellular organelles , growth_hormone , Rab3B , SNAP-25 , and syntaxin in rat pituitary cells caused by growth_hormone_releasing_hormone and somatostatin .
16533151	0	growth_hormone	133,147	growth_hormone_releasing_hormone	42,74	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	secretion|compound|START_ENTITY stimulating|dobj|secretion method|acl|stimulating END_ENTITY|dobj|method	Plasmid-based expression technology using growth_hormone_releasing_hormone : a novel method for physiologically stimulating long-term growth_hormone secretion .
18341090	0	growth_hormone	77,91	growth_hormone_releasing_hormone	32,64	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	status|amod|START_ENTITY evaluate|dobj|status END_ENTITY|xcomp|evaluate	Administration of arginine plus growth_hormone_releasing_hormone to evaluate growth_hormone -LRB- GH -RRB- secretory status in children with GH_deficiency .
1908493	0	growth_hormone	8,22	growth_hormone_releasing_hormone	38,70	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nmod|administration administration|amod|END_ENTITY	Altered growth_hormone response after growth_hormone_releasing_hormone administration in chronic_renal_failure .
2004477	0	growth_hormone	10,24	growth_hormone_releasing_hormone	37,69	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	Increased growth_hormone response to growth_hormone_releasing_hormone induced by erythropoietin in uraemic patients .
20150954	0	growth_hormone	14,28	growth_hormone_releasing_hormone	41,73	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|compound|START_ENTITY response|acl|END_ENTITY	The decreased growth_hormone response to growth_hormone_releasing_hormone in obesity is associated to cardiometabolic risk factors .
2045624	0	growth_hormone	4,18	growth_hormone_releasing_hormone	51,83	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|acl|pyridostigmine pyridostigmine|dobj|END_ENTITY	The growth_hormone response to pyridostigmine plus growth_hormone_releasing_hormone is not influenced by pubertal maturation .
2108920	0	growth_hormone	10,24	growth_hormone_releasing_hormone	38,70	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Increased growth_hormone responses to growth_hormone_releasing_hormone and thyrotropin_releasing_hormone in patients with metastatic testicular_cancer .
2182500	0	growth_hormone	108,122	growth_hormone_releasing_hormone	25,57	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY volunteers|nmod|deficiency injections|nmod|volunteers injections|nmod|END_ENTITY	Repetitive injections of growth_hormone_releasing_hormone -LRB- GHRH1-44 -RRB- to normal volunteers and patients with growth_hormone deficiency .
2195097	0	growth_hormone	4,18	growth_hormone_releasing_hormone	31,63	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	The growth_hormone response to growth_hormone_releasing_hormone in patients previously treated with bilateral adrenalectomy alone for Cushing 's _ disease .
2266772	0	growth_hormone	20,34	growth_hormone_releasing_hormone	66,98	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY Pharmacokinetics|nmod|secretion induced|nsubj|Pharmacokinetics induced|nmod|END_ENTITY	Pharmacokinetics of growth_hormone secretion in humans induced by growth_hormone_releasing_hormone .
2537727	0	growth_hormone	85,99	growth_hormone_releasing_hormone	14,46	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY Comparison|nmod|deficiency Comparison|nmod|therapy therapy|amod|END_ENTITY	Comparison of growth_hormone_releasing_hormone therapy and growth_hormone therapy in growth_hormone deficiency .
2550207	0	growth_hormone	155,169	growth_hormone_releasing_hormone	173,205	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|nmod|START_ENTITY response|acl|END_ENTITY	Growth_hormone_releasing_hormone-sensitive adenylate cyclase activity in growth_hormone-producing pituitary_adenoma : correlation to the response of plasma growth_hormone to growth_hormone_releasing_hormone in patients with acromegaly .
2882405	0	growth_hormone	115,129	growth_hormone_releasing_hormone	69,101	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Selective beta 1-adrenergic receptor-blockade with atenolol enhances growth_hormone_releasing_hormone and mediated growth_hormone release in man .
2907614	0	growth_hormone	142,156	growth_hormone_releasing_hormone	71,103	growth hormone	growth hormone releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	magnitude|nmod|START_ENTITY titrate|dobj|magnitude interacted|xcomp|titrate interacted|nmod|END_ENTITY	Fractional reduction of somatostatin concentration interacted with rat growth_hormone_releasing_hormone to titrate the magnitude of pulsatile growth_hormone and prolactin release in perifusion .
3098462	0	growth_hormone	33,47	growth_hormone_releasing_hormone	60,92	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY oxandrolone|nmod|response effect|nmod|oxandrolone effect|acl|END_ENTITY	The effect of oxandrolone on the growth_hormone response to growth_hormone_releasing_hormone in children with constitutional growth delay .
3106123	0	growth_hormone	46,60	growth_hormone_releasing_hormone	10,42	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of growth_hormone_releasing_hormone on growth_hormone secretion in type 2 -LRB- non-insulin-dependent -RRB- diabetes mellitus .
3113779	0	growth_hormone	75,89	growth_hormone_releasing_hormone	23,55	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY alter|dobj|response alter|nsubj|infusion infusion|nmod|END_ENTITY	Continuous infusion of growth_hormone_releasing_hormone does not alter the growth_hormone response to different stress stimuli .
3115634	0	growth_hormone	15,29	growth_hormone_releasing_hormone	42,74	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY END_ENTITY|nsubj|response	The higher the growth_hormone response to growth_hormone_releasing_hormone the lower the response to bromocriptine and thyrotrophin releasing hormone in acromegaly .
3133146	0	growth_hormone	62,76	growth_hormone_releasing_hormone	132,164	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	deficiency|amod|START_ENTITY activity|nmod|deficiency subset|dobj|activity subset|nmod|END_ENTITY	Lymphocyte subset distribution and natural killer activity in growth_hormone deficiency before and during short-term treatment with growth_hormone_releasing_hormone .
3143655	0	growth_hormone	85,99	growth_hormone_releasing_hormone	41,73	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY stimulated|dobj|secretion stimulated|nsubj|influence influence|nmod|age age|nmod|END_ENTITY	The influence of age on human pancreatic growth_hormone_releasing_hormone stimulated growth_hormone secretion .
3917458	0	growth_hormone	27,41	growth_hormone_releasing_hormone	59,91	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	dexamethasone|nmod|START_ENTITY response|amod|dexamethasone Effect|nmod|response Effect|acl|END_ENTITY	Effect of dexamethasone on growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone in acromegaly .
3927648	0	growth_hormone	26,40	growth_hormone_releasing_hormone	71,103	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	START_ENTITY|xcomp|stimulating stimulating|nmod|END_ENTITY	Evidence of a circulating growth_hormone stimulating factor other than growth_hormone_releasing_hormone in a patient with pituitary_tumour and acromegaly .
7617133	0	growth_hormone	26,40	growth_hormone_releasing_hormone	114,146	growth hormone	growth hormone releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	response|amod|START_ENTITY potentiates|dobj|response potentiates|nmod|challenge challenge|nmod|rats rats|compound|END_ENTITY	Clonidine potentiates the growth_hormone response to a growth_hormone_releasing_hormone challenge in hypothalamic growth_hormone_releasing_hormone deficient rats .
7617133	0	growth_hormone	26,40	growth_hormone_releasing_hormone	55,87	growth hormone	growth hormone releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	response|amod|START_ENTITY potentiates|dobj|response potentiates|nmod|challenge challenge|amod|END_ENTITY	Clonidine potentiates the growth_hormone response to a growth_hormone_releasing_hormone challenge in hypothalamic growth_hormone_releasing_hormone deficient rats .
7681861	0	growth_hormone	48,62	growth_hormone_releasing_hormone	85,117	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	responses|compound|START_ENTITY restores|dobj|responses restores|nmod|stimuli stimuli|compound|END_ENTITY	Galanin infusion partially restores the blunted growth_hormone responses to repeated growth_hormone_releasing_hormone stimuli in normal adults .
7780546	0	growth_hormone	14,28	growth_hormone_releasing_hormone	47,79	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	deficiencies|amod|START_ENTITY Treatment|nmod|deficiencies Treatment|nmod|END_ENTITY	-LSB- Treatment of growth_hormone deficiencies with growth_hormone_releasing_hormone .
7976413	0	growth_hormone	27,41	growth_hormone_releasing_hormone	54,86	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Lowering cortisol enhances growth_hormone response to growth_hormone_releasing_hormone in healthy subjects .
8006330	0	growth_hormone	86,100	growth_hormone_releasing_hormone	113,145	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY enhance|dobj|response enhance|advcl|END_ENTITY	Low doses of either intravenously or orally administered arginine are able to enhance growth_hormone response to growth_hormone_releasing_hormone in elderly subjects .
8241653	0	growth_hormone	45,59	growth_hormone_releasing_hormone	72,104	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Oral administration of arginine enhances the growth_hormone response to growth_hormone_releasing_hormone in short children .
8445152	0	growth_hormone	111,125	growth_hormone_releasing_hormone	56,88	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	secretion|amod|START_ENTITY suppress|dobj|secretion suppress|iobj|NH2-stimulated NH2-stimulated|amod|END_ENTITY	Physiological levels of growth_hormone fail to suppress growth_hormone_releasing_hormone -LRB- 1-29 -RRB- NH2-stimulated growth_hormone secretion in man .
8445152	0	growth_hormone	24,38	growth_hormone_releasing_hormone	56,88	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	levels|nmod|START_ENTITY fail|nsubj|levels fail|xcomp|suppress suppress|iobj|NH2-stimulated NH2-stimulated|amod|END_ENTITY	Physiological levels of growth_hormone fail to suppress growth_hormone_releasing_hormone -LRB- 1-29 -RRB- NH2-stimulated growth_hormone secretion in man .
8513607	0	growth_hormone	63,77	growth_hormone_releasing_hormone	95,127	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	response|amod|START_ENTITY response|nmod|stimulation stimulation|amod|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
8588384	0	growth_hormone	91,105	growth_hormone_releasing_hormone	11,43	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	secretion|nmod|START_ENTITY EEG|dobj|secretion EEG|nsubj|Action Action|nmod|END_ENTITY	-LSB- Action of growth_hormone_releasing_hormone -LRB- GHRH -RRB- on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression -RSB- .
8740245	0	growth_hormone	46,60	growth_hormone_releasing_hormone	10,42	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone_releasing_hormone on growth_hormone , prostaglandin_E2 and insulin in non-insulin-dependent diabetic patients .
8851324	0	growth_hormone	13,27	growth_hormone_releasing_hormone	51,83	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	-LSB- Behavior of growth_hormone after stimulation with growth_hormone_releasing_hormone -LRB- GHRH -RRB- in children with disorders_of_the_hypothalamo-hypophyseal_axis and girls with Turner_syndrome -RSB- .
9007701	0	growth_hormone	14,28	growth_hormone_releasing_hormone	47,79	growth hormone	growth hormone releasing hormone	2688	2691	Gene	Gene	Impairment|nmod|START_ENTITY responsiveness|nsubj|Impairment responsiveness|xcomp|END_ENTITY	Impairment of growth_hormone responsiveness to growth_hormone_releasing_hormone and pyridostigmine in patients affected by Prader-Labhardt-Willi_syndrome .
9176843	0	growth_hormone	80,94	growth_hormone_releasing_hormone	110,142	growth hormone	growth hormone releasing hormone	81668(Tax:10116)	29446(Tax:10116)	Gene	Gene	secrete|dobj|START_ENTITY secrete|advcl|END_ENTITY	Severe uremia depresses the ability of perifused rat pituitary cells to secrete growth_hormone in response to growth_hormone_releasing_hormone .
8892984	0	growth_hormone	24,38	hGH-N	52,57	growth hormone	hGH-N	2688	2688	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the human growth_hormone normal gene -LRB- hGH-N -RRB- in proliferating and differentiated HL-60 cells .
9440818	0	growth_hormone	30,44	hGH_receptor	122,134	growth hormone	hGH receptor	2688	2690	Gene	Gene	differs|nsubj|START_ENTITY differs|nmod|END_ENTITY	The 20-kilodalton -LRB- kDa -RRB- human growth_hormone -LRB- hGH -RRB- differs from the 22-kDa hGH in the complex formation with cell surface hGH_receptor and hGH-binding protein circulating in human plasma .
25229664	0	growth_hormone	52,66	high_mobility_group_box-1	8,33	growth hormone	high mobility group box-1	81668(Tax:10116)	25459(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box-1 and protection of growth_hormone and somatostatin in severe_acute_pancreatitis .
25387675	0	growth_hormone	52,66	high_mobility_group_box-1	8,33	growth hormone	high mobility group box-1	81668(Tax:10116)	25459(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box-1 and protection of growth_hormone and somatostatin in severe_acute_pancreatitis .
10674400	0	growth_hormone	165,179	hnf6	152,156	growth hormone	hnf6	81668(Tax:10116)	25231(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Involvement of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- and HNF-4 -LRB- hepatocyte_nuclear_factor_4 -RRB- in the transcriptional control of the hnf6 gene by growth_hormone .
16340214	0	growth_hormone	175,189	igf-I	11,16	growth hormone	igf-I	2688	3479	Gene	Gene	deficiency|compound|START_ENTITY adults|nmod|deficiency increased|advcl|adults increased|nsubjpass|responsiveness responsiveness|compound|END_ENTITY	Individual igf-I responsiveness to a fixed regimen of low-dose growth_hormone replacement is increased with less variability in obese compared to non-obese adults with severe growth_hormone deficiency .
16340214	0	growth_hormone	63,77	igf-I	11,16	growth hormone	igf-I	2688	3479	Gene	Gene	replacement|compound|START_ENTITY regimen|nmod|replacement responsiveness|nmod|regimen responsiveness|compound|END_ENTITY	Individual igf-I responsiveness to a fixed regimen of low-dose growth_hormone replacement is increased with less variability in obese compared to non-obese adults with severe growth_hormone deficiency .
10100181	0	growth_hormone	26,40	insulin	127,134	growth hormone	insulin	2688	3630	Gene	Gene	levels|nmod|START_ENTITY associated|nsubj|levels associated|nmod|decrease decrease|acl|circulating circulating|dobj|END_ENTITY	Increased serum levels of growth_hormone and insulin-like_growth_factor-I associated with simultaneous decrease of circulating insulin in postmenopausal women receiving hormone replacement therapy .
10484056	0	growth_hormone	50,64	insulin	9,16	growth hormone	insulin	2688	3630	Gene	Gene	response|amod|START_ENTITY contribute|nmod|response contribute|nsubj|levels levels|compound|END_ENTITY	Elevated insulin levels contribute to the reduced growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in obese subjects .
10516135	0	growth_hormone	16,30	insulin	52,59	growth hormone	insulin	81668(Tax:10116)	3630	Gene	Gene	START_ENTITY|acl|induce induce|dobj|resistance resistance|compound|END_ENTITY	Acute effect of growth_hormone to induce peripheral insulin resistance is independent of FFA and insulin levels in rats .
10628433	0	growth_hormone	66,80	insulin	29,36	growth hormone	insulin	2688	3630	Gene	Gene	secretion|nmod|START_ENTITY suppress|dobj|secretion suppress|nsubj|increases increases|nmod|END_ENTITY	Feeding-induced increases in insulin do not suppress secretion of growth_hormone .
10663217	0	growth_hormone	127,141	insulin	5,12	growth hormone	insulin	2688	3630	Gene	Gene	concentrations|amod|START_ENTITY vary|nmod|concentrations vary|nsubj|sensitivity sensitivity|compound|END_ENTITY	Both insulin sensitivity and insulin clearance in children and young adults with type I -LRB- insulin-dependent -RRB- diabetes vary with growth_hormone concentrations and with age .
10703231	0	growth_hormone	101,115	insulin	92,99	growth hormone	insulin	2688	3630	Gene	Gene	START_ENTITY|nsubj|factor factor|appos|END_ENTITY	Relationship_of_insulin-like_growth_factor-I , _ insulin-like_growth factor binding protein-3 , insulin , growth_hormone in cord blood and maternal factors with birth height and birthweight .
11574412	0	growth_hormone	66,80	insulin	39,46	growth hormone	insulin	2688	3630	Gene	Gene	exposure|amod|START_ENTITY restores|nmod|exposure restores|dobj|sensitivity sensitivity|compound|END_ENTITY	Pharmacological antilipolysis restores insulin sensitivity during growth_hormone exposure .
1173985	0	growth_hormone	29,43	insulin	97,104	growth hormone	insulin	2688	3630	Gene	Gene	study|nmod|START_ENTITY cortisol|nsubj|study cortisol|nmod|END_ENTITY	A comparative study of serum growth_hormone and plasma cortisol levels in stimulation tests with insulin and propranolol-glucagon .
12637795	0	growth_hormone	14,28	insulin	44,51	growth hormone	insulin	2688	3630	Gene	Gene	excess|amod|START_ENTITY Inhibition|nmod|excess reduces|nsubj|Inhibition reduces|dobj|resistance resistance|compound|END_ENTITY	Inhibition of growth_hormone excess reduces insulin resistance and ovarian_dysfunction in a lean case of polycystic_ovary_syndrome with a growth-hormone-producing pituitary_adenoma .
1322872	0	growth_hormone	80,94	insulin	20,27	growth hormone	insulin	2688	3630	Gene	Gene	concentration|nmod|START_ENTITY restore|dobj|concentration restore|nsubj|Reduction Reduction|nmod|levels levels|compound|END_ENTITY	Reduction of plasma insulin levels does not restore integrated concentration of growth_hormone to normal in obese children .
14702105	0	growth_hormone	22,36	insulin	62,69	growth hormone	insulin	2688	3630	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|sensitivity sensitivity|compound|END_ENTITY	The relative roles of growth_hormone and IGF-1 in controlling insulin sensitivity .
15131760	0	growth_hormone	51,65	insulin	43,50	growth hormone	insulin	2688	3630	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|nicotine nicotine|nmod|END_ENTITY	Acute effects of nicotine on serum glucose insulin growth_hormone and cortisol in healthy smokers .
15296478	0	growth_hormone	120,134	insulin	11,18	growth hormone	insulin	81668(Tax:10116)	3630	Gene	Gene	replacement|amod|START_ENTITY comparison|nmod|replacement Effects|dep|comparison Effects|nmod|END_ENTITY	Effects of insulin -- like growth factor-I treatment on the endocrine pancreas of hypophysectomized rats : comparison with growth_hormone replacement .
16200849	0	growth_hormone	38,52	insulin	12,19	growth hormone	insulin	2688	3630	Gene	Gene	release|amod|START_ENTITY dose|nmod|release dose|nmod|END_ENTITY	Low dose of insulin for assessment of growth_hormone and cortisol release in short children .
16584518	0	growth_hormone	11,25	insulin	29,36	growth hormone	insulin	2688	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|resistance resistance|compound|END_ENTITY	Effects of growth_hormone on insulin resistance and atherosclerotic risk factors in obese_type_2 diabetic patients with poor glycaemic control .
19609105	0	growth_hormone	77,91	insulin	11,18	growth hormone	insulin	2688	3630	Gene	Gene	treatment|nmod|START_ENTITY levels|nmod|treatment levels|compound|END_ENTITY	Changes in insulin levels following 6-month treatment with recombinant human growth_hormone in growth_hormone-deficient adults .
1988776	0	growth_hormone	10,24	insulin	105,112	growth hormone	insulin	2688	3630	Gene	Gene	secretion|compound|START_ENTITY affect|nsubj|secretion affect|nmod|secretion secretion|compound|END_ENTITY	Nocturnal growth_hormone secretion does not affect diurnal variations in arginine and glucose-stimulated insulin secretion .
20372873	0	growth_hormone	117,131	insulin	9,16	growth hormone	insulin	2688	3630	Gene	Gene	therapy|amod|START_ENTITY preserved|nmod|therapy sensitivity|acl|preserved sensitivity|compound|END_ENTITY	Improved insulin sensitivity , preserved beta cell function and improved whole-body glucose metabolism after low-dose growth_hormone replacement therapy in adults with severe growth_hormone deficiency : a pilot study .
20372873	0	growth_hormone	174,188	insulin	9,16	growth hormone	insulin	2688	3630	Gene	Gene	deficiency|compound|START_ENTITY preserved|nmod|deficiency sensitivity|acl|preserved sensitivity|compound|END_ENTITY	Improved insulin sensitivity , preserved beta cell function and improved whole-body glucose metabolism after low-dose growth_hormone replacement therapy in adults with severe growth_hormone deficiency : a pilot study .
20583540	0	growth_hormone	11,25	insulin	90,97	growth hormone	insulin	2688	3630	Gene	Gene	concentrations|compound|START_ENTITY concentrations|nmod|patients patients|nmod|resistance resistance|compound|END_ENTITY	Stimulated growth_hormone concentrations in obese pediatric patients with mild and severe insulin resistance : a pilot study .
22323865	0	growth_hormone	99,113	insulin	41,48	growth hormone	insulin	2688	3630	Gene	Gene	reduction|nmod|START_ENTITY restored|nmod|reduction restored|nsubjpass|ability ability|nmod|b-cells b-cells|acl|compensate compensate|nmod|resistance resistance|compound|END_ENTITY	The ability of b-cells to compensate for insulin resistance is restored with a reduction in excess growth_hormone in Korean acromegalic patients .
22562529	0	growth_hormone	58,72	insulin	78,85	growth hormone	insulin	2688	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Insulin-like_growth_factor-I correlates more closely than growth_hormone with insulin resistance and glucose_intolerance in patients with acromegaly .
23011065	0	growth_hormone	15,29	insulin	76,83	growth hormone	insulin	2688	3630	Gene	Gene	Suppression|nmod|START_ENTITY ameliorates|nsubj|Suppression ameliorates|dobj|increase increase|nmod|resistance resistance|compound|END_ENTITY	Suppression in growth_hormone during overeating ameliorates the increase in insulin resistance and cardiovascular_disease risk .
2406181	0	growth_hormone	20,34	insulin	175,182	growth hormone	insulin	2688	3630	Gene	Gene	secretion|amod|START_ENTITY spikes|nmod|secretion cause|nsubj|spikes cause|ccomp|diabetes_mellitus diabetes_mellitus|advcl|decreasing decreasing|dobj|sensitivity sensitivity|nmod|END_ENTITY	Nocturnal spikes of growth_hormone secretion cause the dawn phenomenon in type 1 -LRB- insulin-dependent -RRB- diabetes_mellitus by decreasing hepatic -LRB- and extrahepatic -RRB- sensitivity to insulin in the absence of insulin waning .
2406181	0	growth_hormone	20,34	insulin	201,208	growth hormone	insulin	2688	3630	Gene	Gene	secretion|amod|START_ENTITY spikes|nmod|secretion cause|nsubj|spikes cause|ccomp|diabetes_mellitus diabetes_mellitus|advcl|decreasing decreasing|nmod|absence absence|nmod|END_ENTITY	Nocturnal spikes of growth_hormone secretion cause the dawn phenomenon in type 1 -LRB- insulin-dependent -RRB- diabetes_mellitus by decreasing hepatic -LRB- and extrahepatic -RRB- sensitivity to insulin in the absence of insulin waning .
24083170	0	growth_hormone	114,128	insulin	69,76	growth hormone	insulin	2688	3630	Gene	Gene	deficiency|amod|START_ENTITY children|nmod|deficiency resistance|nmod|children resistance|compound|END_ENTITY	Evaluation of left ventricular mass and function , lipid profile , and insulin resistance in Egyptian children with growth_hormone deficiency : A single-center prospective case-control study .
25273336	0	growth_hormone	141,155	insulin	94,101	growth hormone	insulin	2688	3630	Gene	Gene	START_ENTITY|nsubj|capacity capacity|acl|counteract counteract|dobj|increase increase|nmod|resistance resistance|compound|END_ENTITY	Reduction_in_insulin_sensitivity and inadequate b-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth_hormone deficiency during 12 months of growth_hormone treatment .
25273336	0	growth_hormone	188,202	insulin	94,101	growth hormone	insulin	2688	3630	Gene	Gene	treatment|amod|START_ENTITY months|nmod|treatment growth_hormone|nmod|months growth_hormone|nsubj|capacity capacity|acl|counteract counteract|dobj|increase increase|nmod|resistance resistance|compound|END_ENTITY	Reduction_in_insulin_sensitivity and inadequate b-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth_hormone deficiency during 12 months of growth_hormone treatment .
2576005	0	growth_hormone	19,33	insulin	72,79	growth hormone	insulin	2688	3630	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|resistance resistance|compound|END_ENTITY	Combined effect of growth_hormone and cortisol on late posthypoglycemic insulin resistance in humans .
2656349	0	growth_hormone	11,25	insulin	29,36	growth hormone	insulin	2688	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|sensitivity sensitivity|compound|END_ENTITY	Effects of growth_hormone on insulin sensitivity and forearm metabolism in normal man .
2986615	0	growth_hormone	6,20	insulin	48,55	growth hormone	insulin	81668(Tax:10116)	3630	Gene	Gene	START_ENTITY|dobj|binding binding|nmod|biosynthesis biosynthesis|compound|END_ENTITY	Human growth_hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells .
3131129	0	growth_hormone	140,154	insulin	43,50	growth hormone	insulin	2688	3630	Gene	Gene	peptides|nmod|START_ENTITY mice|nmod|peptides treatment|nmod|mice tissue|nmod|treatment tissue|nmod|END_ENTITY	Increased sensitivity of adipose tissue to insulin after in vivo treatment of yellow Avy/A obese mice with amino-terminal peptides of human growth_hormone .
3135175	0	growth_hormone	26,40	insulin	50,57	growth hormone	insulin	81668(Tax:10116)	3630	Gene	Gene	peptide|nmod|START_ENTITY enhances|nsubj|peptide enhances|dobj|action action|compound|END_ENTITY	Amino-terminal peptide of growth_hormone enhances insulin action in normal rats .
3137806	0	growth_hormone	24,38	insulin	40,47	growth hormone	insulin	2688	3630	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of growth_hormone , insulin , free thyroxine , thyrotropin , and cortisol in very-low-birth-weight_infants receiving total parenteral nutrition .
3882538	0	growth_hormone	67,81	insulin	125,132	growth hormone	insulin	100356068(Tax:9986)	100009181(Tax:9986)	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|fatty_acids fatty_acids|compound|END_ENTITY	Different acute in vivo effects of bacterial derived and pituitary growth_hormone preparations on plasma levels of glucagon , insulin and free fatty_acids in rabbits .
4168383	0	growth_hormone	95,109	insulin	31,38	growth hormone	insulin	2688	3630	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|effects effects|nmod|hypoglycaemia hypoglycaemia|compound|END_ENTITY	A comparison of the effects of insulin hypoglycaemia and arginine infusion on release of human growth_hormone .
4421573	0	growth_hormone	45,59	insulin	24,31	growth hormone	insulin	2688	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|enhancement enhancement|nmod|END_ENTITY	In vitro enhancement of insulin secretion by growth_hormone .
4759592	0	growth_hormone	85,99	insulin	152,159	growth hormone	insulin	2688	3630	Gene	Gene	releasing|nmod|START_ENTITY releasing|nmod|END_ENTITY	Isolation and characterization of a pituitary peptidase specifically releasing , from growth_hormone , a peptide -LRB- somantin -RRB- with antagonistic activity to insulin in vitro .
4874761	0	growth_hormone	10,24	insulin	28,35	growth hormone	insulin	2688	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of growth_hormone on insulin secretion .
4882000	0	growth_hormone	35,49	insulin	55,62	growth hormone	insulin	2688	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of pregnancy and chorionic growth_hormone upon insulin secretion .
579023	1	growth_hormone	113,127	insulin	95,102	growth hormone	insulin	2688	3630	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	I. Glucose , insulin and human growth_hormone levels during oral glucose tolerance tests .
6250964	0	growth_hormone	83,97	insulin	26,33	growth hormone	insulin	2688	3630	Gene	Gene	somatomedin|nmod|START_ENTITY somatomedin|compound|END_ENTITY	Association between serum insulin , serum somatomedin and liver receptors for human growth_hormone in streptozotocin diabetes .
6761205	0	growth_hormone	11,25	insulin	29,36	growth hormone	insulin	2688	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|action action|compound|END_ENTITY	Effects of growth_hormone on insulin action in man .
7042427	0	growth_hormone	127,141	insulin	118,125	growth hormone	insulin	2688	3630	Gene	Gene	levels|compound|START_ENTITY glucose|appos|levels glucose|appos|END_ENTITY	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise : blood glucose , plasma insulin , growth_hormone , adrenaline and noradrenaline levels .
719939	0	growth_hormone	89,103	insulin	12,19	growth hormone	insulin	2688	3630	Gene	Gene	-RSB-|compound|START_ENTITY reference|nmod|-RSB- Changes|dep|reference Changes|nmod|antagonists antagonists|compound|END_ENTITY	-LSB- Changes of insulin antagonists in juvenile_diabetes_mellitus -- with special reference to growth_hormone and glucagon -RSB- .
7921208	0	growth_hormone	10,24	insulin	38,45	growth hormone	insulin	2688	3630	Gene	Gene	treatment|amod|START_ENTITY Effect|nmod|treatment Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of growth_hormone treatment on insulin secretion and glucose metabolism in prepubertal boys with short_stature .
9440474	0	growth_hormone	105,119	insulin	68,75	growth hormone	insulin	2688	3630	Gene	Gene	pulsatility|amod|START_ENTITY consequent|nmod|pulsatility requirements|acl|consequent requirements|compound|END_ENTITY	Recombinant human insulin-like growth factor-I abolishes changes in insulin requirements consequent upon growth_hormone pulsatility in young adults with type_I_diabetes_mellitus .
946563	0	growth_hormone	68,82	insulin	30,37	growth hormone	insulin	2688	3630	Gene	Gene	influsion|amod|START_ENTITY sensitivity|nmod|influsion sensitivity|nmod|response response|compound|END_ENTITY	Diminished sensitivity of the insulin response to glucose following growth_hormone influsion in man .
8767634	0	growth_hormone	12,26	insulin-like_growth_factor-1	27,55	growth hormone	insulin-like growth factor-1	2688	3479	Gene	Gene	Changes|nmod|START_ENTITY Changes|dep|axis axis|amod|END_ENTITY	-LSB- Changes in growth_hormone / insulin-like_growth_factor-1 axis in patients with normal pituitary function and biventricular_cardiac_failure and hepatic_stasis -RSB- .
10502457	0	growth_hormone	28,42	insulin-like_growth_factor-I	61,89	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|dep|induction induction|nmod|mRNA mRNA|compound|END_ENTITY	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
10853714	0	growth_hormone	101,115	insulin-like_growth_factor-I	51,79	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	deletions|amod|START_ENTITY children|nmod|deletions END_ENTITY|nmod|children	Lack of reduction in body fat after treatment with insulin-like_growth_factor-I in two children with growth_hormone gene deletions .
11702667	0	growth_hormone	34,48	insulin-like_growth_factor-I	49,77	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	study|nmod|START_ENTITY study|dep|axis axis|amod|END_ENTITY	-LSB- Clinical study on the changes of growth_hormone / insulin-like_growth_factor-I axis in patient with obstructive_jaundice -RSB- .
12682066	0	growth_hormone	68,82	insulin-like_growth_factor-I	17,45	growth hormone	insulin-like growth factor-I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|control control|nmod|gene gene|compound|END_ENTITY	Acute control of insulin-like_growth_factor-I gene transcription by growth_hormone through Stat5b .
12793602	0	growth_hormone	144,158	insulin-like_growth_factor-I	11,39	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	insensitivity|amod|START_ENTITY Laron_syndrome|appos|insensitivity patients|nmod|Laron_syndrome system|nmod|patients Effects|nmod|system Effects|nmod|deficiency deficiency|amod|END_ENTITY	Effects of insulin-like_growth_factor-I deficiency and replacement therapy on the hematopoietic system in patients with Laron_syndrome -LRB- primary growth_hormone insensitivity -RRB- .
1474468	0	growth_hormone	53,67	insulin-like_growth_factor-I	14,42	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of insulin-like_growth_factor-I and human growth_hormone on periodontal ligament fibroblast morphology , growth pattern , DNA synthesis , and receptor binding .
14960017	0	growth_hormone	31,45	insulin-like_growth_factor-I	47,75	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Basal and stimulated levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-I binding and IGF-binding proteins in beta-thalassemia major .
15063105	0	growth_hormone	5,19	insulin-like_growth_factor-I	72,100	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	prevent|nsubj|START_ENTITY prevent|dobj|aging aging|nmod|END_ENTITY	Does growth_hormone prevent aging in the healthy elderly with low serum insulin-like_growth_factor-I ?
15684342	0	growth_hormone	42,56	insulin-like_growth_factor-I	65,93	growth hormone	insulin-like growth factor-I	378781(Tax:9031)	100327329(Tax:9031)	Gene	Gene	effect|nmod|START_ENTITY modulate|dobj|effect modulate|advcl|END_ENTITY	Metabolic hormones modulate the effect of growth_hormone -LRB- GH -RRB- on insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA level in primary culture of salmon hepatocytes .
16214911	0	growth_hormone	25,39	insulin-like_growth_factor-I	85,113	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|relation relation|acl|circulating circulating|dobj|factor factor|compound|END_ENTITY	Genetic variation in the growth_hormone synthesis pathway in relation to circulating insulin-like_growth_factor-I , insulin-like growth factor binding protein-3 , and breast_cancer risk : results from the European prospective investigation into cancer and nutrition study .
1677331	0	growth_hormone	26,40	insulin-like_growth_factor-I	122,150	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	prolactin|compound|START_ENTITY effect|nmod|prolactin mediated|nsubjpass|effect mediated|nmod|END_ENTITY	The stimulatory effect of growth_hormone , prolactin , and placental lactogen on beta-cell proliferation is not mediated by insulin-like_growth_factor-I .
1710624	0	growth_hormone	31,45	insulin-like_growth_factor-I	71,99	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	START_ENTITY|acl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Short and long term effects of growth_hormone on circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-1 , and insulin : a placebo-controlled study .
17407215	0	growth_hormone	185,199	insulin-like_growth_factor-I	99,127	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	response|amod|START_ENTITY improvement|nmod|response improve|nmod|improvement improve|dobj|levels levels|compound|END_ENTITY	A combination of 6 months of treatment with pyridostigmine and triweekly exercise fails to improve insulin-like_growth_factor-I levels in fibromyalgia , despite improvement in the acute growth_hormone response to exercise .
18341092	0	growth_hormone	119,133	insulin-like_growth_factor-I	30,58	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	treatment|compound|START_ENTITY length|advcl|treatment length|nmod|treatment treatment|compound|END_ENTITY	Foot length before and during insulin-like_growth_factor-I treatment of children with laron_syndrome compared to human growth_hormone treatment of children with isolated growth_hormone deficiency .
18341092	0	growth_hormone	170,184	insulin-like_growth_factor-I	30,58	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	deficiency|compound|START_ENTITY children|nmod|deficiency treatment|nmod|children length|advcl|treatment length|nmod|treatment treatment|compound|END_ENTITY	Foot length before and during insulin-like_growth_factor-I treatment of children with laron_syndrome compared to human growth_hormone treatment of children with isolated growth_hormone deficiency .
1909610	0	growth_hormone	40,54	insulin-like_growth_factor-I	129,157	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	levels|compound|START_ENTITY levels|nmod|activity activity|acl|associated associated|nmod|levels levels|nmod|END_ENTITY	Critically_ill patients have high basal growth_hormone levels with attenuated_oscillatory activity associated with low levels of insulin-like_growth_factor-I .
19570739	0	growth_hormone	76,90	insulin-like_growth_factor-I	4,32	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	status|amod|START_ENTITY indicator|nmod|status test|nmod|indicator test|nsubj|generation generation|amod|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- generation test as an indicator of growth_hormone status .
20029798	0	growth_hormone	19,33	insulin-like_growth_factor-I	62,90	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	optimizes|amod|START_ENTITY bioactive|nsubj|optimizes bioactive|dobj|level level|amod|END_ENTITY	Sustained low-dose growth_hormone therapy optimizes bioactive insulin-like_growth_factor-I level and may enhance CD4 T-cell number in HIV_infection .
2189886	0	growth_hormone	58,72	insulin-like_growth_factor-I	127,155	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	administration|nmod|START_ENTITY Pulsatile|nmod|administration Pulsatile|dep|effects effects|acl|circulating circulating|dobj|indices indices|amod|END_ENTITY	Pulsatile versus continuous intravenous administration of growth_hormone -LRB- GH -RRB- in GH-deficient patients : effects on circulating insulin-like_growth_factor-I and metabolic indices .
2229302	0	growth_hormone	215,229	insulin-like_growth_factor-I	36,64	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	treated|nmod|START_ENTITY treated|nsubj|study study|nmod|changes changes|nmod|END_ENTITY	Comparative study of the changes in insulin-like_growth_factor-I , procollagen-III N-terminal extension peptide , bone Gla-protein , and bone mineral content in children with Turner 's _ syndrome treated with recombinant growth_hormone .
22511534	0	growth_hormone	221,235	insulin-like_growth_factor-I	94,122	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	misuse|amod|START_ENTITY detection|nmod|misuse Implications|nmod|detection effects|dep|Implications effects|nmod|cycle cycle|nmod|stability stability|nmod|concentrations concentrations|compound|END_ENTITY	The effects of a freeze-thaw cycle and pre-analytical storage temperature on the stability of insulin-like_growth_factor-I and pro-collagen type III N-terminal propeptide concentrations : Implications for the detection of growth_hormone misuse in athletes .
22524398	0	growth_hormone	23,37	insulin-like_growth_factor-I	38,66	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	usefulness|nmod|START_ENTITY usefulness|dep|axis axis|amod|END_ENTITY	Possible usefulness of growth_hormone / insulin-like_growth_factor-I axis in Alzheimer 's _ disease treatment .
23980167	0	growth_hormone	41,55	insulin-like_growth_factor-I	57,85	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	response|nmod|START_ENTITY response|dep|axis axis|amod|END_ENTITY	SIRT1 regulates adaptive response of the growth_hormone -- insulin-like_growth_factor-I axis under fasting conditions in liver .
2769164	0	growth_hormone	123,137	insulin-like_growth_factor-I	68,96	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	rat|dobj|START_ENTITY antiserum|acl|rat using|dobj|antiserum Inhibition|acl|using Inhibition|nmod|growth growth|nmod|END_ENTITY	Inhibition of neonatal rat growth and circulating concentrations of insulin-like_growth_factor-I using an antiserum to rat growth_hormone .
3289898	1	growth_hormone	101,115	insulin-like_growth_factor-I	56,84	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	concentrations|compound|START_ENTITY effect|nmod|concentrations effect|nmod|END_ENTITY	The effect of insulin-like_growth_factor-I on plasma fetal growth_hormone , insulin and glucose concentrations .
3359980	0	growth_hormone	148,162	insulin-like_growth_factor-I	24,52	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	autoregulation|amod|START_ENTITY implications|nmod|autoregulation Regulation|dep|implications Regulation|nmod|levels levels|compound|END_ENTITY	Regulation of pituitary insulin-like_growth_factor-I messenger ribonucleic_acid levels in rats harboring somatomammotropic tumors : implications for growth_hormone autoregulation .
7476303	0	growth_hormone	35,49	insulin-like_growth_factor-I	96,124	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	resistance|compound|START_ENTITY metabolism|nmod|resistance Carbohydrate|dobj|metabolism Carbohydrate|nmod|treatment treatment|compound|END_ENTITY	Carbohydrate metabolism in primary growth_hormone resistance -LRB- Laron_syndrome -RRB- before and during insulin-like_growth_factor-I treatment .
7513341	0	growth_hormone	180,194	insulin-like_growth_factor-I	8,36	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	3479	Gene	Gene	effect|nmod|START_ENTITY mimic|dobj|effect fail|xcomp|mimic protein-3|acl:relcl|fail analogues|dep|protein-3 analogues|compound|END_ENTITY	Several insulin-like_growth_factor-I analogues and complexes_of_insulin-like_growth_factors-I_and _ - II_with_insulin-like_growth factor-binding protein-3 fail to mimic the effect of growth_hormone upon lactation in the rat .
7513345	0	growth_hormone	10,24	insulin-like_growth_factor-I	45,73	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	START_ENTITY|nmod|steroidogenesis steroidogenesis|appos|END_ENTITY	Effect of growth_hormone on steroidogenesis , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-1 production and DNA synthesis in cultured human luteinized granulosa cells .
7524925	0	growth_hormone	124,138	insulin-like_growth_factor-I	19,47	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY diagnosis|nmod|deficiency measurement|nmod|diagnosis measurement|nsubj|Comparison Comparison|nmod|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7691864	0	growth_hormone	10,24	insulin-like_growth_factor-I	26,54	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	Levels|nmod|START_ENTITY _|nsubj|Levels _|nsubj|END_ENTITY	Levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ and _ - II , _ IGF-binding_protein-1_and _ -3 , and cortisol in prednisone-treated children with growth_retardation after renal transplantation .
7720672	0	growth_hormone	75,89	insulin-like_growth_factor-I	24,52	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY gene|acl|transcription gene|compound|END_ENTITY	Rapid activation of rat insulin-like_growth_factor-I gene transcription by growth_hormone reveals no changes in deoxyribonucleic acid-protein interactions within the second promoter .
7799357	0	growth_hormone	129,143	insulin-like_growth_factor-I	99,127	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	START_ENTITY|nsubj|insulin insulin|appos|END_ENTITY	Growth promoting peptides in osteoarthritis and diffuse_idiopathic_skeletal_hyperostosis -- insulin , insulin-like_growth_factor-I , growth_hormone .
7925121	0	growth_hormone	75,89	insulin-like_growth_factor-I	24,52	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY gene|acl|transcription gene|compound|END_ENTITY	Rapid activation of rat insulin-like_growth_factor-I gene transcription by growth_hormone reveals no alterations in deoxyribonucleic acid-protein interactions within the major promoter .
8254284	0	growth_hormone	21,35	insulin-like_growth_factor-I	112,140	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|dep|composition composition|nmod|END_ENTITY	Interactions between growth_hormone and nutrition in hypophysectomized rats : body composition and production of insulin-like_growth_factor-I .
8632230	0	growth_hormone	75,89	insulin-like_growth_factor-I	110,138	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	abolishes|nmod|START_ENTITY abolishes|dobj|concentrations concentrations|compound|END_ENTITY	Moderate food restriction abolishes the pregnancy-associated rise in serum growth_hormone and decreases serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations without altering IGF-I mRNA expression in rats .
8788308	0	growth_hormone	104,118	insulin-like_growth_factor-I	15,43	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	steroids|compound|START_ENTITY regulation|nmod|steroids release|dep|regulation release|nmod|END_ENTITY	The release of insulin-like_growth_factor-I by luteinized human granulosa cells in vitro : regulation by growth_hormone , oxytocin , steroids and cAMP-dependent intracellular mechanisms .
8816035	0	growth_hormone	19,33	insulin-like_growth_factor-I	77,105	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	response|amod|START_ENTITY response|dep|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
9041052	0	growth_hormone	163,177	insulin-like_growth_factor-I	77,105	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY adults|nmod|deficiency alkaline|nmod|adults alkaline|nmod|END_ENTITY	Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like_growth_factor-I -LRB- IGF-I -RRB- and during growth_hormone therapy in adults with growth_hormone deficiency .
9096605	0	growth_hormone	11,25	insulin-like_growth_factor-I	30,58	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	singly|dep|START_ENTITY singly|advmod|END_ENTITY	Effects of growth_hormone and insulin-like_growth_factor-I singly and in combination on in vivo capacity of urea synthesis , gene expression of urea cycle enzymes , and organ nitrogen contents in rats .
9225125	0	growth_hormone	26,40	insulin-like_growth_factor-I	119,147	growth hormone	insulin-like growth factor-I	378781(Tax:9031)	100327329(Tax:9031)	Gene	Gene	administration|nmod|START_ENTITY exerts|nsubj|administration exerts|advcl|circulating circulating|dobj|concentrations concentrations|nmod|END_ENTITY	Chronic administration of growth_hormone -LRB- GH -RRB- to adult chickens exerts marked effects on circulating concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF binding proteins , hepatic GH regulated gene I , and hepatic GH_receptor mRNA .
9231798	0	growth_hormone	14,28	insulin-like_growth_factor-I	115,143	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|dep|role role|nmod|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- gene expression and secretion during pregnancy and lactation in the rat : role of insulin-like_growth_factor-I , somatostatin , and GH-releasing_hormone .
9555872	0	growth_hormone	74,88	insulin-like_growth_factor-I	89,117	growth hormone	insulin-like growth factor-I	2688	3479	Gene	Gene	/|amod|START_ENTITY END_ENTITY|amod|/	Alcohol withdrawal-induced change in lipoprotein -LRB- a -RRB- : association with the growth_hormone / insulin-like_growth_factor-I -LRB- IGF-I -RRB- / IGF-binding_protein-1 -LRB- IGFBP-1 -RRB- axis .
9886844	0	growth_hormone	79,93	insulin-like_growth_factor-I	47,75	growth hormone	insulin-like growth factor-I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Molecular mechanisms of the negative effect of insulin-like_growth_factor-I on growth_hormone gene expression in MtT/S somatotroph cells .
15166120	0	growth_hormone	101,115	insulin-like_growth_factor-binding_protein-1	24,68	growth hormone	insulin-like growth factor-binding protein-1	2688	3484	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels Administration|acl|circulating Administration|nmod|increases increases|amod|END_ENTITY	Administration of human insulin-like_growth_factor-binding_protein-1 increases circulating levels of growth_hormone in mice .
1705656	0	growth_hormone	93,107	insulin-like_growth_factor-binding_protein-1	34,78	growth hormone	insulin-like growth factor-binding protein-1	81668(Tax:10116)	25685(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of rat insulin-like_growth_factor-binding_protein-1 expression by growth_hormone .
10848878	0	growth_hormone	78,92	insulin-like_growth_factor_1	11,39	growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY diagnosis|nmod|deficiency values|nmod|diagnosis values|nsubj|use use|nmod|reference reference|amod|END_ENTITY	The use of insulin-like_growth_factor_1 reference values for the diagnosis of growth_hormone deficiency in prepubertal children .
15178913	0	growth_hormone	24,38	insulin-like_growth_factor_1	95,123	growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	insensitivity|amod|START_ENTITY Laron_syndrome|appos|insensitivity Laron_syndrome|dep|model model|acl|explore explore|dobj|effect effect|nmod|deficiency deficiency|amod|END_ENTITY	Laron_syndrome -LRB- primary growth_hormone insensitivity -RRB- : a unique model to explore the effect of insulin-like_growth_factor_1 deficiency on human hair .
16984235	0	growth_hormone	35,49	insulin-like_growth_factor_1	75,103	growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	concentrations|compound|START_ENTITY concentrations|nmod|administration administration|amod|END_ENTITY	Short-term suppression of elevated growth_hormone concentrations following insulin-like_growth_factor_1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates .
23648743	0	growth_hormone	221,235	insulin-like_growth_factor_1	60,88	growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	gene|amod|START_ENTITY Monitoring|parataxis|gene Monitoring|nmod|activity activity|nmod|END_ENTITY	Monitoring for potential residual_disease activity by serum insulin-like_growth_factor_1 and soluble Klotho in patients with acromegaly after pituitary surgery : is there an impact of the genomic deletion of exon 3 in the growth_hormone receptor -LRB- d3-GHR -RRB- gene on `` safe '' GH cut-off values ?
8389243	0	growth_hormone	4,18	insulin-like_growth_factor_1	20,48	growth hormone	insulin-like growth factor 1	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|dep|mediator mediator|nsubj|axis axis|amod|END_ENTITY	The growth_hormone : insulin-like_growth_factor_1 axis is a mediator of diet restriction-induced inhibition_of_mononuclear_cell_leukemia in Fischer rats .
9500574	0	growth_hormone	6,20	insulin-like_growth_factor_1	145,173	growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	levels|compound|START_ENTITY correlated|nsubjpass|levels correlated|nmod|cholesterol cholesterol|nmod|END_ENTITY	Basal growth_hormone levels in women are positively correlated with high-density lipoprotein cholesterol and apolipoprotein_A-I independently of insulin-like_growth_factor_1 or insulin .
9923061	0	growth_hormone	56,70	insulin-like_growth_factor_1	109,137	growth hormone	insulin-like growth factor 1	2688	3479	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Improved nasal breathing in snorers increases nocturnal growth_hormone secretion and serum concentrations of insulin-like_growth_factor_1 subsequently .
10336548	0	growth_hormone	62,76	insulin-like_growth_factor_I	101,129	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	effects|compound|START_ENTITY model|nmod|effects model|nmod|END_ENTITY	A pharmacokinetic/pharmacodynamic model for recombinant human growth_hormone effects on induction of insulin-like_growth_factor_I in monkeys .
10720049	0	growth_hormone	62,76	insulin-like_growth_factor_I	21,49	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	treatment|amod|START_ENTITY response|nmod|treatment response|compound|END_ENTITY	Gender difference in insulin-like_growth_factor_I response to growth_hormone -LRB- GH -RRB- treatment in GH-deficient adults : role of sex hormone replacement .
10965059	0	growth_hormone	25,39	insulin-like_growth_factor_I	50,78	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Presumptive mediators of growth_hormone action on insulin-like_growth_factor_I release by porcine ovarian granulosa cells .
11684882	0	growth_hormone	89,103	insulin-like_growth_factor_I	32,60	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY diagnosing|dobj|deficiency assays|advcl|diagnosing assays|xcomp|available available|nmod|END_ENTITY	Commercial assays available for insulin-like_growth_factor_I and their use in diagnosing growth_hormone deficiency .
11735250	0	growth_hormone	14,28	insulin-like_growth_factor_I	32,60	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|metabolism metabolism|compound|END_ENTITY	The effect of growth_hormone on insulin-like_growth_factor_I and bone metabolism in distraction osteogenesis .
1282673	0	growth_hormone	10,24	insulin-like_growth_factor_I	63,91	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Effect of growth_hormone on levels of differentially processed insulin-like_growth_factor_I mRNAs in total and polysomal mRNA populations .
1453131	0	growth_hormone	37,51	insulin-like_growth_factor_I	101,129	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	deficiency|compound|START_ENTITY bone_mineral_density|nmod|deficiency correlates|nsubj|bone_mineral_density correlates|advcl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	The bone_mineral_density in acquired growth_hormone deficiency correlates with circulating levels of insulin-like_growth_factor_I .
14997011	0	growth_hormone	130,144	insulin-like_growth_factor_I	20,48	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	exogenous|amod|START_ENTITY binding|nmod|exogenous binding|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of brain insulin-like_growth_factor_I -LRB- IGF-I -RRB- binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth_hormone and IGF-I in juvenile rats .
1518079	0	growth_hormone	59,73	insulin-like_growth_factor_I	27,55	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	hormone|compound|START_ENTITY regulation|nmod|hormone regulation|nmod|END_ENTITY	Differential regulation of insulin-like_growth_factor_I by growth_hormone and thyroid hormone in the heart of juvenile hypophysectomized rats .
16862465	0	growth_hormone	170,184	insulin-like_growth_factor_I	29,57	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	_|amod|START_ENTITY patients|nmod|_ changes|nmod|patients changes|nmod|END_ENTITY	Pregnancy-induced changes in insulin-like_growth_factor_I -LRB- IGF-I -RRB- , insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- , and acid-labile_subunit -LRB- ALS -RRB- in patients with growth_hormone _ -LRB- GH -RRB- _ deficiency and excess .
1723834	0	growth_hormone	110,124	insulin-like_growth_factor_I	21,49	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	insensitivity|amod|START_ENTITY case|nmod|insensitivity END_ENTITY|nmod|case	Effects of exogenous insulin-like_growth_factor_I on insulin-like growth factor binding proteins in a case of growth_hormone insensitivity -LRB- Laron-type -RRB- .
1879059	0	growth_hormone	39,53	insulin-like_growth_factor_I	121,149	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY characteristics|nmod|therapy characteristics|dep|linkage linkage|nmod|gene gene|amod|END_ENTITY	Growth characteristics and response to growth_hormone therapy in patients with hypochondroplasia : genetic linkage of the insulin-like_growth_factor_I gene at chromosome 12q23 to the disease in a subgroup of these patients .
19055455	0	growth_hormone	129,143	insulin-like_growth_factor_I	28,56	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	IGF-I|nmod|START_ENTITY assays|nmod|IGF-I assays|nsubj|END_ENTITY	Five commercially available insulin-like_growth_factor_I -LRB- IGF-I -RRB- assays in comparison to the former Nichols Advantage IGF-I in a growth_hormone treated population .
1991807	0	growth_hormone	94,108	insulin-like_growth_factor_I	125,153	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	START_ENTITY|dep|secretion secretion|appos|END_ENTITY	Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth_hormone -LRB- GH -RRB- secretion , insulin-like_growth_factor_I , and GH-binding protein in postmenopausal women .
2340951	0	growth_hormone	109,123	insulin-like_growth_factor_I	15,43	growth hormone	insulin-like growth factor I	378781(Tax:9031)	100327329(Tax:9031)	Gene	Gene	hepatocytes|nmod|START_ENTITY hepatocytes|nsubj|Stimulation Stimulation|nmod|production production|compound|END_ENTITY	Stimulation of insulin-like_growth_factor_I production in primary cultures of chicken hepatocytes by chicken growth_hormone .
23578901	0	growth_hormone	53,67	insulin-like_growth_factor_I	74,102	growth hormone	insulin-like growth factor I	102171600	100860838	Gene	Gene	sequences|nmod|START_ENTITY Variation|nmod|sequences _|advcl|Variation _|nsubj|END_ENTITY	Variation in sequences and mRNA expression levels of growth_hormone -LRB- GH -RRB- , insulin-like_growth_factor_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- genes between prolific Lezhi black goat and non-prolific Tibetan goat -LRB- Capra_hircus -RRB- .
2492219	0	growth_hormone	94,108	insulin-like_growth_factor_I	45,73	growth hormone	insulin-like growth factor I	81668(Tax:10116)	3479	Gene	Gene	secretion|amod|START_ENTITY interrelationship|nmod|secretion interrelationship|nmod|effects effects|nmod|END_ENTITY	The interrelationship between the effects of insulin-like_growth_factor_I and somatostatin on growth_hormone secretion by normal rat pituitary cells : the role of glucocorticoids .
2849979	0	growth_hormone	48,62	insulin-like_growth_factor_I	78,106	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	vitro|nmod|START_ENTITY erythropoiesis|acl|vitro Enhancement|nmod|erythropoiesis mediated|nsubjpass|Enhancement mediated|nmod|END_ENTITY	Enhancement of erythropoiesis in vitro by human growth_hormone is mediated by insulin-like_growth_factor_I .
2982573	0	growth_hormone	75,89	insulin-like_growth_factor_I	15,43	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Rat hepatocyte insulin-like_growth_factor_I and binding protein : effect of growth_hormone in vitro and in vivo .
3197637	0	growth_hormone	22,36	insulin-like_growth_factor_I	87,115	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|acid acid|amod|END_ENTITY	Pulsatile intravenous growth_hormone -LRB- GH -RRB- infusion to hypophysectomized rats increases insulin-like_growth_factor_I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion .
3383777	0	growth_hormone	86,100	insulin-like_growth_factor_I	14,42	growth hormone	insulin-like growth factor I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY transgenic_mice|nmod|levels END_ENTITY|nmod|transgenic_mice	Expression of insulin-like_growth_factor_I in transgenic_mice with elevated levels of growth_hormone is correlated with growth .
3453891	0	growth_hormone	161,175	insulin-like_growth_factor_I	25,53	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	messenger|nmod|START_ENTITY END_ENTITY|parataxis|messenger	Molecular cloning of rat insulin-like_growth_factor_I complementary deoxyribonucleic acids : differential messenger ribonucleic acid processing and regulation by growth_hormone in extrahepatic tissues .
3467309	0	growth_hormone	62,76	insulin-like_growth_factor_I	14,42	growth hormone	insulin-like growth factor I	14599(Tax:10090)	16000(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of insulin-like_growth_factor_I gene expression by growth_hormone .
3654610	0	growth_hormone	20,34	insulin-like_growth_factor_I	54,82	growth hormone	insulin-like growth factor I	2688	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of human growth_hormone gene expression by insulin-like_growth_factor_I in transfected cells .
8514857	0	growth_hormone	127,141	insulin-like_growth_factor_I	52,80	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	secretion|compound|START_ENTITY suppresses|dobj|secretion suppresses|nsubj|infusion infusion|nmod|END_ENTITY	A low dose euglycemic infusion of recombinant human insulin-like_growth_factor_I rapidly suppresses fasting-enhanced pulsatile growth_hormone secretion in humans .
8567947	1	growth_hormone	84,98	insulin-like_growth_factor_I	118,146	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY mediated|nsubjpass|stimulation mediated|nmod|END_ENTITY	In vivo stimulation by growth_hormone is not mediated by insulin-like_growth_factor_I .
8630517	0	growth_hormone	59,73	insulin-like_growth_factor_I	12,40	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	deficiency|amod|START_ENTITY free|nmod|deficiency free|dobj|concentrations concentrations|compound|END_ENTITY	Plasma free insulin-like_growth_factor_I concentrations in growth_hormone deficiency in children and adolescents .
8768860	0	growth_hormone	93,107	insulin-like_growth_factor_I	51,79	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	therapy|compound|START_ENTITY therapy|amod|END_ENTITY	A randomized , placebo-controlled trial of combined insulin-like_growth_factor_I and low dose growth_hormone therapy for wasting associated with human_immunodeficiency_virus_infection .
8770900	0	growth_hormone	31,45	insulin-like_growth_factor_I	53,81	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	infusions|nmod|START_ENTITY Effects|nmod|infusions END_ENTITY|nsubj|Effects	Effects of 14-day infusions of growth_hormone and/or insulin-like_growth_factor_I on the obesity of growing Zucker rats .
8810735	0	growth_hormone	99,113	insulin-like_growth_factor_I	33,61	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	levels|nmod|START_ENTITY depends|nmod|levels depends|nsubj|increase increase|nmod|levels levels|amod|END_ENTITY	Testosterone-induced increase of insulin-like_growth_factor_I levels depends upon normal levels of growth_hormone .
8989263	0	growth_hormone	146,160	insulin-like_growth_factor_I	6,34	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	therapy|amod|START_ENTITY IGF-binding_protein-1_and|nmod|therapy IGF-binding_protein-1_and|nsubj|END_ENTITY	Serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-1_and _ -3 , and the acid-labile_subunit as serum markers of body composition during growth_hormone -LRB- GH -RRB- therapy in adults with GH_deficiency .
9025720	0	growth_hormone	85,99	insulin-like_growth_factor_I	115,143	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|synthesis synthesis|amod|END_ENTITY	Proinflammatory cytokines interleukin_1_beta and tumor_necrosis_factor_alpha inhibit growth_hormone stimulation of insulin-like_growth_factor_I synthesis and growth_hormone_receptor mRNA levels in cultured rat liver cells .
9104840	0	growth_hormone	46,60	insulin-like_growth_factor_I	10,38	growth hormone	insulin-like growth factor I	81668(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|and/or and/or|compound|END_ENTITY	Effect of insulin-like_growth_factor_I and/or growth_hormone on diaphragm of malnourished adolescent rats .
9253329	0	growth_hormone	54,68	insulin-like_growth_factor_I	11,39	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|Effects Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I combined with growth_hormone on glucocorticoid-induced whole-body protein catabolism in man .
9284715	0	growth_hormone	19,33	insulin-like_growth_factor_I	66,94	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	treatment|compound|START_ENTITY response|nmod|treatment relates|nsubj|response relates|xcomp|serum serum|dobj|END_ENTITY	Growth response to growth_hormone -LRB- GH -RRB- treatment relates to serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 in short children with various GH secretion capacities .
9661598	0	growth_hormone	151,165	insulin-like_growth_factor_I	39,67	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	status|amod|START_ENTITY evaluation|nmod|status assay|nmod|evaluation assay|nmod|END_ENTITY	Filter paper blood spot assay of human insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 and preliminary application in the evaluation of growth_hormone status .
9920097	0	growth_hormone	76,90	insulin-like_growth_factor_I	29,57	growth hormone	insulin-like growth factor I	2688	3479	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|administration administration|compound|END_ENTITY	Effects of recombinant human insulin-like_growth_factor_I administration on growth_hormone -LRB- GH -RRB- secretion , both spontaneous and stimulated by GH-releasing hormone or hexarelin , a peptidyl GH secretagogue , in humans .
10670759	0	growth_hormone	99,113	insulin-like_growth_factor_binding_protein-3	26,70	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency Absence|nmod|patients Absence|nmod|proteolysis proteolysis|nmod|END_ENTITY	Absence of proteolysis of insulin-like_growth_factor_binding_protein-3 in serum from patients with growth_hormone deficiency .
1284115	0	growth_hormone	116,130	insulin-like_growth_factor_binding_protein-3	44,88	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	deficiency|amod|START_ENTITY diagnosis|nmod|deficiency Usefulness|nmod|diagnosis Usefulness|nmod|measurement measurement|nmod|END_ENTITY	Usefulness and limitation of measurement of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- for diagnosis of growth_hormone deficiency .
12901539	0	growth_hormone	99,113	insulin-like_growth_factor_binding_protein-3	26,70	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Diagnostic value of serum insulin-like_growth_factor_binding_protein-3 in children with or without growth_hormone deficiency .
18984657	0	growth_hormone	174,188	insulin-like_growth_factor_binding_protein-3	21,65	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	associated|xcomp|START_ENTITY associated|nsubjpass|allele allele|nmod|polymorphism polymorphism|amod|END_ENTITY	The -202 A allele of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- promoter polymorphism is associated with higher IGFBP-3 serum levels and better growth response to growth_hormone treatment in patients with severe growth_hormone deficiency .
18984657	0	growth_hormone	223,237	insulin-like_growth_factor_binding_protein-3	21,65	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	deficiency|compound|START_ENTITY patients|nmod|deficiency growth_hormone|nmod|patients associated|xcomp|growth_hormone associated|nsubjpass|allele allele|nmod|polymorphism polymorphism|amod|END_ENTITY	The -202 A allele of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- promoter polymorphism is associated with higher IGFBP-3 serum levels and better growth response to growth_hormone treatment in patients with severe growth_hormone deficiency .
21648284	0	growth_hormone	76,90	insulin-like_growth_factor_binding_protein-3	12,56	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	testing|amod|START_ENTITY Evidence|nmod|testing Evidence|nmod|proteolysis proteolysis|amod|END_ENTITY	Evidence of insulin-like_growth_factor_binding_protein-3 proteolysis during growth_hormone stimulation testing .
24927347	0	growth_hormone	33,47	insulin-like_growth_factor_binding_protein-3	80,124	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Age related secretary pattern of growth_hormone , insulin-like growth factor-I _ insulin-like_growth_factor_binding_protein-3 in postmenopausal women .
7518726	0	growth_hormone	130,144	insulin-like_growth_factor_binding_protein-3	20,64	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	children|nmod|START_ENTITY evaluation|nmod|children END_ENTITY|nmod|evaluation	Clinical utility of insulin-like_growth_factor_binding_protein-3 in the evaluation and treatment of short children with suspected growth_hormone deficiency .
7545763	0	growth_hormone	27,41	insulin-like_growth_factor_binding_protein-3	53,97	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Adjuvant recombinant human growth_hormone stimulates insulin-like_growth_factor_binding_protein-3 secretion in critically ill trauma patients .
9543142	0	growth_hormone	13,27	insulin-like_growth_factor_binding_protein-3	37,81	growth hormone	insulin-like growth factor binding protein-3	2688	3486	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|proteolysis proteolysis|amod|END_ENTITY	No effect of growth_hormone on serum insulin-like_growth_factor_binding_protein-3 proteolysis .
12198566	0	growth_hormone	45,59	interferon-gamma	18,34	growth hormone	interferon-gamma	81668(Tax:10116)	25712(Tax:10116)	Gene	Gene	-LSB-|dep|START_ENTITY -LSB-|dobj|mechanism mechanism|nmod|increases increases|amod|END_ENTITY	-LSB- The mechanism of interferon-gamma increases growth_hormone expression in rat pituitary GH -LRB- 3 -RRB- cells -RSB- .
11880162	0	growth_hormone	17,31	interferon_gamma	43,59	growth hormone	interferon gamma	2688	3458	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|compound|END_ENTITY	Human lymphocyte growth_hormone stimulates interferon_gamma production and is inhibited by cortisol and norepinephrine .
17027521	0	growth_hormone	43,57	interleukin-1	26,39	growth hormone	interleukin-1	2688	3552	Gene	Gene	action|amod|START_ENTITY END_ENTITY|nmod|action	The inhibitory effects of interleukin-1 on growth_hormone action during catabolic_illness .
2100277	0	growth_hormone	134,148	interleukin-1_alpha	14,33	growth hormone	interleukin-1 alpha	2688	3552	Gene	Gene	deficiency|amod|START_ENTITY degree|nmod|deficiency cells|nmod|degree Production|nmod|cells Production|nmod|END_ENTITY	Production of interleukin-1_alpha and interleukin-2 by mononuclear cells from children with growth delay in relation to the degree of growth_hormone deficiency : effects of substitutive treatment .
1641070	0	growth_hormone	30,44	interleukin-1_beta	58,76	growth hormone	interleukin-1 beta	81668(Tax:10116)	24494(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Stimulation and inhibition of growth_hormone secretion by interleukin-1_beta : the involvement of growth_hormone-releasing hormone .
19180878	0	growth_hormone	32,46	interleukin-1_beta	10,28	growth hormone	interleukin-1 beta	81668(Tax:10116)	24494(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Effect of interleukin-1_beta on growth_hormone gene expression and its possible molecular mechanism in rat MtT/S somatotroph cells .
15266826	0	growth_hormone	43,57	interleukin-1beta	14,31	growth hormone	interleukin-1beta	81668(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	-LSB- Mechanism of interleukin-1beta increasing growth_hormone expression in rat pituitary GH3 cells -RSB- .
16043966	0	growth_hormone	43,57	interleukin-1beta	22,39	growth hormone	interleukin-1beta	81668(Tax:10116)	24494(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Stimulatory effect of interleukin-1beta on growth_hormone gene expression and growth_hormone release from rat GH3 cells .
11061508	0	growth_hormone	57,71	interleukin-6	42,55	growth hormone	interleukin-6	2688	3569	Gene	Gene	cortisol|amod|START_ENTITY cortisol|amod|END_ENTITY	Effects of sleep_and_sleep_deprivation on interleukin-6 , growth_hormone , cortisol , and melatonin levels in humans .
16807770	0	growth_hormone	41,55	interleukin-6	17,30	growth hormone	interleukin-6	2688	3569	Gene	Gene	START_ENTITY|nsubj|Co-expression Co-expression|nmod|END_ENTITY	Co-expression of interleukin-6 and human growth_hormone in apparently normal prostate biopsies that ultimately progress to prostate_cancer using low pH , high temperature antigen retrieval .
18074473	0	growth_hormone	13,27	interleukin-6	41,54	growth hormone	interleukin-6	2688	3569	Gene	Gene	Overture|nmod|START_ENTITY Overture|dep|requiem requiem|nmod|END_ENTITY	Overture for growth_hormone : requiem for interleukin-6 ?
18686625	0	growth_hormone	99,113	interleukin-6	76,89	growth hormone	interleukin-6	2688	3569	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth_hormone gene expression in rat MtT/S somatotroph cells .
10077348	0	growth_hormone	64,78	leptin	6,12	growth hormone	leptin	2688	3952	Gene	Gene	administration|nmod|START_ENTITY concentrations|nmod|administration concentrations|compound|END_ENTITY	Serum leptin concentrations during short-term administration of growth_hormone and triiodothyronine in healthy adults : a randomised , double-blind placebo-controlled study .
10484132	0	growth_hormone	11,25	leptin	46,52	growth hormone	leptin	378781(Tax:9031)	373955(Tax:9031)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of growth_hormone and pair-feeding on leptin mRNA expression in liver and adipose tissue .
10523000	0	growth_hormone	35,49	leptin	6,12	growth hormone	leptin	2688	3952	Gene	Gene	secretion|amod|START_ENTITY correlate|nmod|secretion correlate|nsubj|levels levels|compound|END_ENTITY	Serum leptin levels correlate with growth_hormone secretion and body fat in children .
10614542	0	growth_hormone	42,56	leptin	85,91	growth hormone	leptin	2688	3952	Gene	Gene	levels|amod|START_ENTITY changes|nmod|levels alter|nsubj|changes alter|dobj|levels levels|amod|END_ENTITY	Arginine infusion and/or acute changes of growth_hormone levels do not acutely alter leptin serum levels .
11022201	0	growth_hormone	63,77	leptin	101,107	growth hormone	leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY rats|nmod|levels obesity|nmod|rats Development|nmod|obesity Development|dep|involvement involvement|nmod|resistance resistance|compound|END_ENTITY	Development of obesity in transgenic rats with low circulating growth_hormone levels : involvement of leptin resistance .
11053487	0	growth_hormone	11,25	leptin	29,35	growth hormone	leptin	2688	3952	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|metabolism metabolism|compound|END_ENTITY	Effects of growth_hormone on leptin metabolism and energy expenditure in hemodialysis patients with protein-calorie_malnutrition .
11322504	0	growth_hormone	33,47	leptin	23,29	growth hormone	leptin	2688	3952	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	The in vitro effect of leptin on growth_hormone secretion from primary cultured ovine somatotrophs .
11720898	0	growth_hormone	99,113	leptin	10,16	growth hormone	leptin	2688	3952	Gene	Gene	treatment|amod|START_ENTITY necrosis|nmod|treatment necrosis|nsubj|END_ENTITY	Increased leptin and tumour necrosis factor alpha per unit fat mass in hypopituitary women without growth_hormone treatment .
12519870	0	growth_hormone	18,32	leptin	92,98	growth hormone	leptin	2688	3952	Gene	Gene	secretion|amod|START_ENTITY inhibition|nmod|secretion mediated|nsubjpass|inhibition mediated|nmod|levels levels|compound|END_ENTITY	The inhibition of growth_hormone secretion presented in obesity is not mediated by the high leptin levels : a study in human leptin_deficiency patients .
12721156	0	growth_hormone	72,86	leptin	20,26	growth hormone	leptin	2688	3952	Gene	Gene	mass|appos|START_ENTITY Characterization|nmod|mass Characterization|nmod|dynamics dynamics|amod|END_ENTITY	Characterization of leptin pulse dynamics and relationship to fat mass , growth_hormone , cortisol , and insulin .
15830113	0	growth_hormone	21,35	leptin	11,17	growth hormone	leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Effect of leptin on growth_hormone secretion and apoptosis of GH3 cells -RSB- .
16626817	0	growth_hormone	56,70	leptin	107,113	growth hormone	leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Effects of central infusion and immunoneutralization of growth_hormone on the timing of puberty and plasma leptin levels in the female rat .
17204837	0	growth_hormone	11,25	leptin	87,93	growth hormone	leptin	2688	3952	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|ghrelin ghrelin|appos|END_ENTITY	Effects of growth_hormone on growth , insulin resistance and related hormones -LRB- ghrelin , leptin and adiponectin -RRB- in Turner_syndrome .
19297186	0	growth_hormone	31,45	leptin	21,27	growth hormone	leptin	81668(Tax:10116)	25608(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Inhibitory effect of leptin on growth_hormone secretion of GH3 cells : involvement of cell proliferation , apoptosis and intracellular free Ca2 + .
19596030	0	growth_hormone	23,37	leptin	53,59	growth hormone	leptin	2688	3952	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Influence of long-term growth_hormone replacement on leptin and ghrelin in GH_deficiency before and after glucose load .
22093818	0	growth_hormone	44,58	leptin	60,66	growth hormone	leptin	2688	3952	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	A higher response of plasma neuropeptide_Y , growth_hormone , leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose_tissue to Acipimox during exercise in patients with bulimia_nervosa : single-blind , randomized , microdialysis study .
9025709	0	growth_hormone	34,48	leptin	58,64	growth hormone	leptin	2688	3952	Gene	Gene	START_ENTITY|nmod|concentrations concentrations|compound|END_ENTITY	Effects of glucocorticoids and of growth_hormone on serum leptin concentrations in man .
9039344	0	growth_hormone	9,23	leptin	50,56	growth hormone	leptin	2688	3952	Gene	Gene	replacement|compound|START_ENTITY lowers|nsubj|replacement lowers|dobj|END_ENTITY	Low-dose growth_hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth_hormone_deficiency .
9302388	0	growth_hormone	21,35	leptin	55,61	growth hormone	leptin	2688	3952	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- status , serum leptin and body composition in healthy and GH_deficient elderly subjects .
9368507	0	growth_hormone	104,118	leptin	6,12	growth hormone	leptin	2688	3952	Gene	Gene	treatment|amod|START_ENTITY response|nmod|treatment relationship|nmod|response END_ENTITY|dep|relationship	Serum leptin in short children born small for gestational age : relationship with the growth response to growth_hormone treatment .
9691208	0	growth_hormone	30,44	leptin	6,12	growth hormone	leptin	2688	3952	Gene	Gene	therapy|amod|START_ENTITY suppressed|nmod|therapy suppressed|nsubjpass|END_ENTITY	Serum leptin is suppressed by growth_hormone therapy in growth_hormone-deficient children .
9713555	0	growth_hormone	47,61	leptin	24,30	growth hormone	leptin	2688	3952	Gene	Gene	deficient_hypopituitary_adults|amod|START_ENTITY preserved|nmod|deficient_hypopituitary_adults preserved|nsubjpass|rhythm rhythm|nmod|END_ENTITY	The circadian rhythm of leptin is preserved in growth_hormone deficient_hypopituitary_adults .
9734619	0	growth_hormone	64,78	leptin	6,12	growth hormone	leptin	2688	3952	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|compound|END_ENTITY	Acute leptin regulation in end-stage_renal_failure : the role of growth_hormone and IGF-1 .
9768649	0	growth_hormone	10,24	leptin	57,63	growth hormone	leptin	2688	3952	Gene	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on serum concentrations of leptin : study in patients with acromegaly and GH_deficiency .
9829605	0	growth_hormone	78,92	leptin	7,13	growth hormone	leptin	2688	3952	Gene	Gene	effect|nmod|START_ENTITY levels|dep|effect levels|compound|END_ENTITY	Plasma leptin levels in trauma patients : effect of adjuvant recombinant human growth_hormone in intravenously fed multiple trauma patients .
9867083	0	growth_hormone	45,59	leptin	24,30	growth hormone	leptin	2688	3952	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Serum leptin levels and leptin expression in growth_hormone -LRB- GH -RRB- - deficient and healthy adults : influence of GH treatment , gender , and fasting .
23940039	0	growth_hormone	97,111	leptin_receptor_overlapping_transcript	154,192	growth hormone	leptin receptor overlapping transcript	14599(Tax:10090)	230514(Tax:10090)	Gene	Gene	START_ENTITY|advcl|inducing inducing|dobj|END_ENTITY	Increased expression of fibroblast_growth_factor_21 -LRB- FGF21 -RRB- during chronic undernutrition causes growth_hormone insensitivity in chondrocytes by inducing leptin_receptor_overlapping_transcript -LRB- LEPROT -RRB- and leptin_receptor_overlapping_transcript-like 1 -LRB- LEPROTL1 -RRB- expression .
8415619	0	growth_hormone	105,119	low_density_lipoprotein-receptor	132,164	growth hormone	low density lipoprotein-receptor	81668(Tax:10116)	300438(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Loss of resistance to dietary cholesterol in the rat after hypophysectomy : importance of the presence of growth_hormone for hepatic low_density_lipoprotein-receptor expression .
15308683	0	growth_hormone	58,72	mechano_growth_factor	7,28	growth hormone	mechano growth factor	14599(Tax:10090)	17311(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Muscle mechano_growth_factor is preferentially induced by growth_hormone in growth_hormone-deficient lit/lit mice .
22093818	0	growth_hormone	44,58	neuropeptide_Y	28,42	growth hormone	neuropeptide Y	2688	4852	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	A higher response of plasma neuropeptide_Y , growth_hormone , leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose_tissue to Acipimox during exercise in patients with bulimia_nervosa : single-blind , randomized , microdialysis study .
23090692	0	growth_hormone	71,85	neuropeptide_Y	24,38	growth hormone	neuropeptide Y	81668(Tax:10116)	24604(Tax:10116)	Gene	Gene	pulses|amod|START_ENTITY involvement|nmod|pulses involvement|nmod|END_ENTITY	Possible involvement of neuropeptide_Y in photo-induced suppression of growth_hormone pulses .
7690118	0	growth_hormone	134,148	neuropeptide_Y	116,130	growth hormone	neuropeptide Y	81668(Tax:10116)	24604(Tax:10116)	Gene	Gene	pattern|amod|START_ENTITY END_ENTITY|nmod|pattern	Effect of parenteral administration of selected nutrients and central injection of gamma-globulin from antiserum to neuropeptide_Y on growth_hormone secretory pattern in food-deprived rats .
8884982	0	growth_hormone	39,53	neuropeptide_Y	21,35	growth hormone	neuropeptide Y	81668(Tax:10116)	24604(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Inhibitory effect of neuropeptide_Y on growth_hormone secretion in rats is mediated by both Y1 - and Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial_basal_hypothalamus .
8923503	0	growth_hormone	33,47	neuropeptide_Y	15,29	growth hormone	neuropeptide Y	2688	4852	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Stimulation by neuropeptide_Y of growth_hormone secretion in prolactinoma in vivo .
9574834	0	growth_hormone	56,70	neuropeptide_Y	38,52	growth hormone	neuropeptide Y	2688	4852	Gene	Gene	secretion|amod|START_ENTITY effects|nmod|secretion effects|nmod|END_ENTITY	Stimulatory and inhibitory effects of neuropeptide_Y on growth_hormone secretion in acromegaly in vivo .
3344067	0	growth_hormone	35,49	neurophysin_II	8,22	growth hormone	neurophysin II	81668(Tax:10116)	280728(Tax:9913)	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Bovine ` neurophysin_II ' stimulates growth_hormone release in the estradiol-primed male rat .
24748824	0	growth_hormone	161,175	pen	136,139	growth hormone	pen	2688	340348	Gene	Gene	deficiency|amod|START_ENTITY treatment|nmod|deficiency END_ENTITY|nmod|treatment	Results from an international multicenter trial evaluating the ease-of-use of and preference for a newly developed disposable injection pen for the treatment of growth_hormone deficiency in treatment-na ve children and adults .
8563072	0	growth_hormone	46,60	pen	38,41	growth hormone	pen	2688	340348	Gene	Gene	treatment|amod|START_ENTITY END_ENTITY|nmod|treatment	Patient evaluation of a new injection pen for growth_hormone treatment in children and adults .
10534168	0	growth_hormone	46,60	placental_lactogen	61,79	growth hormone	placental lactogen	2688	1443	Gene	Gene	pattern|nmod|START_ENTITY pattern|dep|END_ENTITY	The testis-specific expression pattern of the growth_hormone / placental_lactogen -LRB- GH/PL -RRB- gene cluster changes with malignancy .
8894644	0	growth_hormone	62,76	placental_lactogen	39,57	growth hormone	placental lactogen	443329(Tax:9940)	443319(Tax:9940)	Gene	Gene	administration|amod|START_ENTITY _|compound|administration _|compound|END_ENTITY	Differential effects of maternal ovine placental_lactogen and growth_hormone -LRB- GH -RRB- administration on GH_receptor , insulin-like_growth_factor _ -LRB- IGF -RRB- -1 and IGF binding protein-3 gene expression in the pregnant and fetal sheep .
9329365	0	growth_hormone	10,24	placental_lactogen	25,43	growth hormone	placental lactogen	2688	1443	Gene	Gene	transcription|dep|START_ENTITY transcription|compound|END_ENTITY	Selective growth_hormone / placental_lactogen gene transcription and hormone production in pre - and postmenopausal human ovaries .
9428574	0	growth_hormone	51,65	placental_lactogen	20,38	growth hormone	placental lactogen	2688	1443	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of human placental_lactogen and variant growth_hormone genes in placentas .
3595528	0	growth_hormone	81,95	placental_lactogen_II	31,52	growth hormone	placental lactogen II	14599(Tax:10090)	18776(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	The lipolytic effects of mouse placental_lactogen_II , mouse prolactin , and mouse growth_hormone on adipose tissue from virgin and pregnant mice .
10900161	0	growth_hormone	83,97	prolactin	72,81	growth hormone	prolactin	14599(Tax:10090)	19109(Tax:10090)	Gene	Gene	insulin-like_growth_factor-I|dep|START_ENTITY insulin-like_growth_factor-I|compound|END_ENTITY	Humoral and cell-mediated immunity in mice with genetic_deficiencies of prolactin , growth_hormone , insulin-like_growth_factor-I , and thyroid hormone .
12668880	0	growth_hormone	32,46	prolactin	20,29	growth hormone	prolactin	14599(Tax:10090)	19109(Tax:10090)	Gene	Gene	Ames|amod|START_ENTITY Ames|dep|Body Body|nmod|END_ENTITY	Body composition of prolactin - , growth_hormone , and thyrotropin-deficient Ames dwarf mice .
1428057	0	growth_hormone	31,45	prolactin	48,57	growth hormone	prolactin	2688	5617	Gene	Gene	pituitary_adenomas|compound|START_ENTITY pituitary_adenomas|compound|END_ENTITY	Ultrastructural study of mixed growth_hormone _ prolactin secreting pituitary_adenomas .
18063946	0	growth_hormone	58,72	prolactin	21,30	growth hormone	prolactin	2688	5617	Gene	Gene	deficiency|amod|START_ENTITY secretion|nmod|deficiency secretion|nsubj|pattern pattern|nmod|END_ENTITY	Circadian pattern of prolactin secretion in children with growth_hormone deficiency and congenital_organic_lesions in the hypothalamic-pituitary region .
18367632	0	growth_hormone	89,103	prolactin	38,47	growth hormone	prolactin	2688	5617	Gene	Gene	mice|compound|START_ENTITY Effects|nmod|mice Effects|nmod|mechanism mechanism|amod|END_ENTITY	Effects of every-other-day feeding on prolactin regulatory mechanism in transgenic human growth_hormone mice .
2004940	0	growth_hormone	24,38	prolactin	69,78	growth hormone	prolactin	2688	5617	Gene	Gene	producing|dep|START_ENTITY adenomas|amod|producing irradiation|nmod|adenomas irradiation|dep|END_ENTITY	External irradiation of growth_hormone producing pituitary adenomas : prolactin as a marker of hypothalamic and pituitary effects .
20138183	0	growth_hormone	102,116	prolactin	91,100	growth hormone	prolactin	100534452	100534523	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Acute salinity challenges in Mozambique and Nile_tilapia : differential responses of plasma prolactin , growth_hormone and branchial expression of ion transporters .
24959807	0	growth_hormone	76,90	prolactin	31,40	growth hormone	prolactin	2688	5617	Gene	Gene	secretion|amod|START_ENTITY dependent|nmod|secretion dependent|nsubj|Changes Changes|nmod|rhythm rhythm|nmod|END_ENTITY	Changes in circadian rhythm of prolactin in short children are dependent on growth_hormone secretion .
2676483	0	growth_hormone	27,41	prolactin	10,19	growth hormone	prolactin	81668(Tax:10116)	24683(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolactin versus growth_hormone on islet function and the importance of using homologous mammosomatotropic hormones .
2909523	1	growth_hormone	163,177	prolactin	178,187	growth hormone	prolactin	2688	5617	Gene	Gene	family|amod|START_ENTITY family|compound|END_ENTITY	Flounder growth_hormone deduced from the cDNA sequence has the minimal size in the growth_hormone prolactin gene family .
2909523	1	growth_hormone	89,103	prolactin	178,187	growth hormone	prolactin	2688	5617	Gene	Gene	has|nsubj|START_ENTITY has|dobj|size size|nmod|family family|compound|END_ENTITY	Flounder growth_hormone deduced from the cDNA sequence has the minimal size in the growth_hormone prolactin gene family .
2969772	0	growth_hormone	28,42	prolactin	17,26	growth hormone	prolactin	2688	5617	Gene	Gene	START_ENTITY|nsubj|cortisol cortisol|appos|END_ENTITY	Plasma cortisol , prolactin , growth_hormone , and immunoreactive beta-endorphin response to fenfluramine challenge in depressed patients .
343464	0	growth_hormone	37,51	prolactin	53,62	growth hormone	prolactin	2688	5617	Gene	Gene	Variation|amod|START_ENTITY Variation|appos|END_ENTITY	Variation of blood glucose and serum growth_hormone , prolactin and insulin in subjects with insulin-dependent_diabetes , after OGTT and pretreatment with 2-Br-alpha-ergocryptine .
564386	0	growth_hormone	11,25	prolactin	165,174	growth hormone	prolactin	102171600	100861193	Gene	Gene	Release|nmod|START_ENTITY Release|appos|stimuli stimuli|nmod|END_ENTITY	Release of growth_hormone in lactating and non-lactating goats in relation to behaviour , stages of sleep , electroencephalograms , environmental stimuli and levels of prolactin , insulin , glucose and free fatty_acids in the circulation .
6310918	0	growth_hormone	67,81	prolactin	12,21	growth hormone	prolactin	2688	5617	Gene	Gene	secretion|amod|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	The role of prolactin in the inhibitory action of bromocriptine on growth_hormone secretion in acromegaly .
6310921	0	growth_hormone	45,59	prolactin	34,43	growth hormone	prolactin	81668(Tax:10116)	24683(Tax:10116)	Gene	Gene	thyroid|advmod|START_ENTITY thyroid|nsubj|Effects Effects|nmod|trifluoperazine trifluoperazine|nmod|END_ENTITY	Effects of trifluoperazine on rat prolactin , growth_hormone , thyroid stimulating hormone and adrenocorticotrophin secretion in vitro .
6424103	0	growth_hormone	126,140	prolactin	60,69	growth hormone	prolactin	2688	5617	Gene	Gene	deficiency|compound|START_ENTITY stimulates|nmod|deficiency stimulates|dobj|secretion secretion|compound|END_ENTITY	Synthetic hpGRF 1-40 stimulates growth_hormone and inhibits prolactin secretion in normal children and children with isolated growth_hormone deficiency .
6424103	0	growth_hormone	32,46	prolactin	60,69	growth hormone	prolactin	2688	5617	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Synthetic hpGRF 1-40 stimulates growth_hormone and inhibits prolactin secretion in normal children and children with isolated growth_hormone deficiency .
6807686	0	growth_hormone	80,94	prolactin	20,29	growth hormone	prolactin	2688	5617	Gene	Gene	responsiveness|nmod|START_ENTITY prediction|nmod|responsiveness levels|nmod|prediction levels|compound|END_ENTITY	The value of plasma prolactin levels in the prediction of the responsiveness of growth_hormone secretion to bromocriptine and TRH in acromegaly .
7002371	0	growth_hormone	44,58	prolactin	4,13	growth hormone	prolactin	2688	5617	Gene	Gene	metoclopramide|nmod|START_ENTITY response|acl|metoclopramide response|compound|END_ENTITY	The prolactin response to metoclopramide in growth_hormone deficient adolescent males .
7178369	0	growth_hormone	54,68	prolactin	113,122	growth hormone	prolactin	2688	5617	Gene	Gene	phentolamine|nmod|START_ENTITY secretion|amod|phentolamine effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of phentolamine on diazepam-induced growth_hormone secretion and lack of effect of diazepam on prolactin secretion in man .
8055814	0	growth_hormone	13,27	prolactin	85,94	growth hormone	prolactin	2688	5617	Gene	Gene	value|amod|START_ENTITY value|nmod|levels levels|compound|END_ENTITY	-LSB- Response of growth_hormone to sandostatin and bromocriptine and prognostic value of prolactin levels in serum and thyroliberin test in patients with active acromegaly -RSB- .
8257923	0	growth_hormone	43,57	prolactin	32,41	growth hormone	prolactin	2688	5617	Gene	Gene	cannabidiol|amod|START_ENTITY cannabidiol|nmod|END_ENTITY	Effect of cannabidiol on plasma prolactin , growth_hormone and cortisol in human volunteers .
8416024	0	growth_hormone	90,104	prolactin	106,115	growth hormone	prolactin	2688	5617	Gene	Gene	hormone|dep|START_ENTITY hormone|dep|END_ENTITY	Influence of partial_sleep_deprivation on the secretion of thyrotropin , thyroid hormones , growth_hormone , prolactin , luteinizing hormone , follicle stimulating hormone , and estradiol in healthy young women .
8451535	0	growth_hormone	31,45	prolactin	47,56	growth hormone	prolactin	2688	5617	Gene	Gene	triiodothyronine|compound|START_ENTITY triiodothyronine|dep|END_ENTITY	Running-induced alterations in growth_hormone , prolactin , triiodothyronine , and thyroxine concentrations in trained and untrained men and women .
9062871	0	growth_hormone	45,59	prolactin	34,43	growth hormone	prolactin	81668(Tax:10116)	24683(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Twenty-four hour rhythms of serum prolactin , growth_hormone and luteinizing hormone levels , and of medial basal hypothalamic corticotropin-releasing_hormone levels and dopamine and serotonin metabolism in rats neonatally administered melatonin .
2123920	0	growth_hormone	4,18	prolactin_and_TSH	20,37	growth hormone	prolactin and TSH	2688	5617	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	The growth_hormone , prolactin_and_TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary_adenoma .
24683423	0	growth_hormone	64,78	prolactin_receptor	96,114	growth hormone	prolactin receptor	2688	5618	Gene	Gene	START_ENTITY|xcomp|binding binding|nmod|END_ENTITY	In silico investigation of pH-dependence of prolactin and human growth_hormone binding to human prolactin_receptor .
10831629	0	growth_hormone	11,25	renin	35,40	growth hormone	renin	81668(Tax:10116)	24715(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of growth_hormone on renal renin gene expression in normal rats and rats with myocardial_infarction .
1342592	0	growth_hormone	96,110	somatomedin-C	56,69	growth hormone	somatomedin-C	2688	3479	Gene	Gene	generation|nmod|START_ENTITY generation|amod|END_ENTITY	Effects of testosterone on growth_hormone secretion and somatomedin-C generation in prepubertal growth_hormone deficient male patients .
2033295	0	growth_hormone	39,53	somatomedin-C	55,68	growth hormone	somatomedin-C	2688	3479	Gene	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	Correlation between the level of serum growth_hormone ; somatomedin-C ; anthropometric measurements and the liver functions in chronic liver_diseases .
3926476	0	growth_hormone	86,100	somatomedin_C	14,27	growth hormone	somatomedin C	2688	3479	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Plasma GH and somatomedin_C responses to single and repeated administrations of human growth_hormone releasing factor -LRB- hGRF -RRB- .
1138156	0	growth_hormone	64,78	somatostatin	48,60	growth hormone	somatostatin	2688	6750	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Dose-response study of the inhibiting effect of somatostatin on growth_hormone and insulin secretion in normal subjects and acromegalic patients .
11416047	0	growth_hormone	66,80	somatostatin	98,110	growth hormone	somatostatin	2688	6750	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	A novel function of prolactin-releasing peptide in the control of growth_hormone via secretion of somatostatin from the hypothalamus .
12200751	0	growth_hormone	96,110	somatostatin	36,48	growth hormone	somatostatin	2688	6750	Gene	Gene	response|amod|START_ENTITY responsible|nmod|response responsible|nsubj|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	Complete inhibition of hypothalamic somatostatin activity is only partially responsible for the growth_hormone response to strenuous exercise .
14977577	0	growth_hormone	10,24	somatostatin	28,40	growth hormone	somatostatin	2688	6750	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	The serum growth_hormone to somatostatin ratio is skewed upward in rheumatoid_arthritis patients .
15103227	0	growth_hormone	68,82	somatostatin	27,39	growth hormone	somatostatin	2688	6750	Gene	Gene	pituitary_tumors|amod|START_ENTITY subtype|nmod|pituitary_tumors subtype|nsubj|Expression Expression|nmod|receptor receptor|compound|END_ENTITY	Expression and function of somatostatin receptor subtype 1 in human growth_hormone secreting pituitary_tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs .
15580171	0	growth_hormone	51,65	somatostatin	74,86	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	causes|dobj|START_ENTITY causes|nmod|END_ENTITY	Intermittent hypoxia causes a suppressed pituitary growth_hormone through somatostatin .
1675149	0	growth_hormone	66,80	somatostatin	34,46	growth hormone	somatostatin	2688	6750	Gene	Gene	pituitary_gland_tumor|compound|START_ENTITY precursor|nmod|pituitary_gland_tumor precursor|compound|END_ENTITY	-LSB- Presence and characterization of somatostatin precursor in human growth_hormone secreting pituitary_gland_tumor -RSB- .
1684144	2	growth_hormone	94,108	somatostatin	78,90	growth hormone	somatostatin	443329(Tax:9940)	443006(Tax:9940)	Gene	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of somatostatin on growth_hormone and glucose levels .
1684229	0	growth_hormone	88,102	somatostatin	9,21	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	release|amod|START_ENTITY inhibition|nmod|release stress|dobj|inhibition stress|nsubj|Roles Roles|nmod|END_ENTITY	Roles of somatostatin and growth_hormone-releasing_factor in ether stress inhibition of growth_hormone release .
1969759	0	growth_hormone	52,66	somatostatin	36,48	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|infusions infusions|nmod|END_ENTITY	Effect of intermittent infusions of somatostatin on growth_hormone secretion in unrestrained male rats with hypothalamic deafferentation .
1976218	0	growth_hormone	38,52	somatostatin	22,34	growth hormone	somatostatin	2688	6750	Gene	Gene	regulation|amod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Physiological role of somatostatin on growth_hormone regulation in humans .
23696563	0	growth_hormone	85,99	somatostatin	11,23	growth hormone	somatostatin	14599(Tax:10090)	20604(Tax:10090)	Gene	Gene	release|compound|START_ENTITY regulating|nmod|release critical|advcl|regulating critical|nsubj|END_ENTITY	Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth_hormone and insulin release in mice .
23855876	0	growth_hormone	119,133	somatostatin	29,41	growth hormone	somatostatin	14599(Tax:10090)	20604(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY neurones|nmod|secretion neurones|nsubj|distribution distribution|nmod|mRNA mRNA|compound|END_ENTITY	Hypothalamic distribution of somatostatin mRNA expressing neurones relative to pubertal and adult changes in pulsatile growth_hormone secretion in mice .
2564339	0	growth_hormone	39,53	somatostatin	120,132	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY action|nmod|secretion action|dep|interaction interaction|nmod|END_ENTITY	Insulin-like growth factor-I action on growth_hormone secretion and messenger ribonucleic_acid levels : interaction with somatostatin .
2566942	0	growth_hormone	113,127	somatostatin	241,253	growth hormone	somatostatin	2688	6750	Gene	Gene	effect|nmod|START_ENTITY effect|acl|releasing releasing|nmod|man man|appos|act act|nmod|release release|nmod|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2571099	0	growth_hormone	102,116	somatostatin	131,143	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	START_ENTITY|acl|triggering triggering|dobj|release release|compound|END_ENTITY	Physiological role of somatostatin-mediated autofeedback regulation for growth_hormone : importance of growth_hormone in triggering somatostatin release during a trough period of pulsatile growth_hormone release in conscious male rats .
2571099	0	growth_hormone	188,202	somatostatin	131,143	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	release|compound|START_ENTITY period|nmod|release triggering|nmod|period triggering|dobj|release release|compound|END_ENTITY	Physiological role of somatostatin-mediated autofeedback regulation for growth_hormone : importance of growth_hormone in triggering somatostatin release during a trough period of pulsatile growth_hormone release in conscious male rats .
2571099	0	growth_hormone	72,86	somatostatin	131,143	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|dep|importance importance|nmod|growth_hormone growth_hormone|acl|triggering triggering|dobj|release release|compound|END_ENTITY	Physiological role of somatostatin-mediated autofeedback regulation for growth_hormone : importance of growth_hormone in triggering somatostatin release during a trough period of pulsatile growth_hormone release in conscious male rats .
2575238	0	growth_hormone	81,95	somatostatin	29,41	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY actions|nmod|secretion actions|nmod|END_ENTITY	Intrahypothalamic actions of somatostatin and growth_hormone_releasing_factor on growth_hormone secretion .
2860119	0	growth_hormone	70,84	somatostatin	4,16	growth hormone	somatostatin	2688	6750	Gene	Gene	secretion|amod|START_ENTITY inhibition|nmod|secretion induces|dobj|inhibition induces|nsubj|201-995 201-995|compound|END_ENTITY	The somatostatin analog SMS 201-995 induces long-acting inhibition of growth_hormone secretion without rebound hypersecretion in acromegalic patients .
2874559	0	growth_hormone	125,139	somatostatin	54,66	growth hormone	somatostatin	2688	6750	Gene	Gene	caused|ccomp|START_ENTITY caused|nmod|END_ENTITY	Hyperpolarization of the membrane potential caused by somatostatin in dissociated human pituitary_adenoma cells that secrete growth_hormone .
2878009	0	growth_hormone	22,36	somatostatin	63,75	growth hormone	somatostatin	2688	6750	Gene	Gene	START_ENTITY|nmod|SMS_201-995 SMS_201-995|compound|END_ENTITY	The response of serum growth_hormone levels to the long-acting somatostatin analog SMS_201-995 in acromegaly .
2885995	0	growth_hormone	60,74	somatostatin	18,30	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|SMS_201-995 SMS_201-995|compound|END_ENTITY	The effect of the somatostatin analog SMS_201-995 on normal growth_hormone secretion in the rat .
2898964	0	growth_hormone	37,51	somatostatin	11,23	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY antiserum|nmod|levels antiserum|compound|END_ENTITY	Effects of somatostatin antiserum on growth_hormone levels in rats with periventricular lesions in the anterior hypothalamus .
2903171	0	growth_hormone	33,47	somatostatin	61,73	growth hormone	somatostatin	2688	6750	Gene	Gene	sensitivity|nmod|START_ENTITY Comparison|nmod|sensitivity secretion|nsubj|Comparison secretion|nmod|END_ENTITY	Comparison of the sensitivity of growth_hormone secretion to somatostatin in vivo and in vitro in acromegaly .
2903866	0	growth_hormone	20,34	somatostatin	71,83	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|advcl|suppressing suppressing|dobj|secretion secretion|compound|END_ENTITY	Arginine stimulates growth_hormone secretion by suppressing endogenous somatostatin secretion .
2906083	0	growth_hormone	23,37	somatostatin	53,65	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|nmod|infusion infusion|compound|END_ENTITY	The rebound release of growth_hormone -LRB- GH -RRB- following somatostatin infusion in rats involves hypothalamic GH-releasing_factor release .
2907415	0	growth_hormone	25,39	somatostatin	49,61	growth hormone	somatostatin	2688	6750	Gene	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	The suppression of blood growth_hormone level by somatostatin infusion in patients with active acromegaly .
2908268	0	growth_hormone	61,75	somatostatin	137,149	growth hormone	somatostatin	2688	6750	Gene	Gene	expression|amod|START_ENTITY studies|nmod|expression studies|dep|effects effects|nmod|factor factor|compound|END_ENTITY	Quantitative in-situ hybridization histochemistry studies on growth_hormone -LRB- GH -RRB- gene expression in acromegalic somatotrophs : effects of somatostatin , GH-releasing factor and cortisol .
391394	0	growth_hormone	76,90	somatostatin	47,59	growth hormone	somatostatin	14599(Tax:10090)	20604(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|correlation correlation|nmod|END_ENTITY	Developmental correlation between hypothalamic somatostatin and hypophysial growth_hormone .
4514982	0	growth_hormone	99,113	somatostatin	21,33	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY inhibits|dobj|secretion peptide|acl:relcl|inhibits structure|appos|peptide structure|nmod|END_ENTITY	Primary structure of somatostatin , a hypothalamic peptide that inhibits the secretion of pituitary growth_hormone .
6113951	0	growth_hormone	39,53	somatostatin	78,90	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY secretion|nsubj|inhibition secretion|nmod|analogs analogs|compound|END_ENTITY	Potent , highly selective inhibition of growth_hormone secretion by position 4 somatostatin analogs .
6115330	0	growth_hormone	86,100	somatostatin	24,36	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Differential effects of somatostatin on the release of bioactive and immunoactive rat growth_hormone in vitro .
6116553	0	growth_hormone	64,78	somatostatin	48,60	growth hormone	somatostatin	2688	6750	Gene	Gene	pancreatic|dep|START_ENTITY hormones|amod|pancreatic Effect|nmod|hormones Effect|nmod|analogue analogue|nmod|END_ENTITY	Effect of a long-acting octapeptide analogue of somatostatin on growth_hormone and pancreatic and gastrointestinal hormones in man .
6141133	0	growth_hormone	87,101	somatostatin	11,23	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY inhibition|nmod|secretion reverse|dobj|inhibition antiserum|xcomp|reverse antiserum|nsubj|Failure Failure|nmod|END_ENTITY	Failure of somatostatin antiserum to reverse histamine-induced inhibition of pulsatile growth_hormone secretion .
6143299	0	growth_hormone	76,90	somatostatin	28,40	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY Involvement|nmod|secretion Involvement|nmod|END_ENTITY	Involvement of hypothalamic somatostatin in glucagon-induced suppression of growth_hormone secretion in conscious rats .
6146235	0	growth_hormone	21,35	somatostatin	107,119	growth hormone	somatostatin	2688	6750	Gene	Gene	Inhibition|nmod|START_ENTITY secretion|nsubj|Inhibition secretion|nmod|administration administration|nmod|END_ENTITY	Inhibition of foetal growth_hormone -LRB- GH -RRB- and thyrotrophin -LRB- TSH -RRB- secretion after maternal administration of somatostatin .
658886	0	growth_hormone	56,70	somatostatin	22,34	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY regulation|nmod|secretion END_ENTITY|nmod|regulation	-LSB- Role of hypothalamic somatostatin in the regulation of growth_hormone secretion in the rat -LRB- author 's transl -RRB- -RSB- .
667280	0	growth_hormone	51,65	somatostatin	10,22	growth hormone	somatostatin	2688	6750	Gene	Gene	secretion|amod|START_ENTITY Action|nmod|secretion Action|nmod|END_ENTITY	Action of somatostatin , levodopa and pyridoxine on growth_hormone -LRB- GH -RRB- secretion in newborn infants .
7901787	0	growth_hormone	26,40	somatostatin	193,205	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	response|compound|START_ENTITY potentiates|dobj|response potentiates|parataxis|evidence evidence|nmod|control control|nmod|release release|nmod|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
815507	0	growth_hormone	11,25	somatostatin	45,57	growth hormone	somatostatin	2688	6750	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Effects of growth_hormone inhibiting factor -LRB- somatostatin -RRB- on the release of growth_hormone and prolactin from pituitaries of the domestic fowl in vitro .
815507	0	growth_hormone	77,91	somatostatin	45,57	growth hormone	somatostatin	2688	6750	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|factor factor|appos|END_ENTITY	Effects of growth_hormone inhibiting factor -LRB- somatostatin -RRB- on the release of growth_hormone and prolactin from pituitaries of the domestic fowl in vitro .
9200665	0	growth_hormone	13,27	somatostatin	102,114	growth hormone	somatostatin	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|dep|involvement involvement|nmod|END_ENTITY	Influence of growth_hormone on cysteamine-induced gastro-duodenal_lesions in rats : the involvement of somatostatin .
1356334	0	growth_hormone	113,127	somatostatin_and_GH-releasing_factor	73,109	growth hormone	somatostatin and GH-releasing factor	2688	6750	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effectors of ATP-sensitive K + channels inhibit the regulatory effects of somatostatin_and_GH-releasing_factor on growth_hormone secretion .
2881773	0	growth_hormone	33,47	somatostatin_and_GH-releasing_factor	75,111	growth hormone	somatostatin and GH-releasing factor	81668(Tax:10116)	24797(Tax:10116)	Gene	Gene	suppression|amod|START_ENTITY Mechanisms|nmod|suppression Mechanisms|dep|roles roles|nmod|END_ENTITY	Mechanisms of calcitonin-induced growth_hormone -LRB- GH -RRB- suppression : roles of somatostatin_and_GH-releasing_factor .
17609438	0	growth_hormone	59,73	suppressor_of_cytokine_signaling_3	14,48	growth hormone	suppressor of cytokine signaling 3	2688	9021	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOC3 -RRB- by growth_hormone in pro-B cells .
3718412	0	growth_hormone	52,66	thrombin	40,48	growth hormone	thrombin	2688	2147	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Biochemistry of tumor cell thrombosis : thrombin as growth_hormone -RSB- .
3923149	0	growth_hormone	25,39	thyrotrophin-releasing_hormone	53,83	growth hormone	thyrotrophin-releasing hormone	443329(Tax:9940)	101122470	Gene	Gene	control|nmod|START_ENTITY secretion|nsubj|control secretion|nmod|END_ENTITY	Physiological control of growth_hormone secretion by thyrotrophin-releasing_hormone in the domestic fowl .
2907311	0	growth_hormone	120,134	thyrotropin-releasing_factor	88,116	growth hormone	thyrotropin-releasing factor	2688	7200	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Synergism and diurnal variations of human growth_hormone-releasing factor -LRB- 1-29 -RRB- NH2 and thyrotropin-releasing_factor on growth_hormone release in dairy calves .
10831641	0	growth_hormone	29,43	thyrotropin-releasing_hormone	123,152	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	therapy|compound|START_ENTITY modify|nsubj|therapy modify|advcl|END_ENTITY	Short-term recombinant human growth_hormone therapy does not modify growth_hormone , thyrotropin and prolactin responses to thyrotropin-releasing_hormone in adult dialysis patients .
10831641	0	growth_hormone	68,82	thyrotropin-releasing_hormone	123,152	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|compound|START_ENTITY modify|dobj|responses modify|advcl|END_ENTITY	Short-term recombinant human growth_hormone therapy does not modify growth_hormone , thyrotropin and prolactin responses to thyrotropin-releasing_hormone in adult dialysis patients .
109274	2	growth_hormone	122,136	thyrotropin-releasing_hormone	52,81	growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone on in vitro biosynthesis and release of growth_hormone and prolactin .
11979395	0	growth_hormone	13,27	thyrotropin-releasing_hormone	40,69	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Preoperative growth_hormone response to thyrotropin-releasing_hormone and oral glucose tolerance test in acromegaly : a retrospective evaluation of 50 patients .
122426	0	growth_hormone	65,79	thyrotropin-releasing_hormone	10,39	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of thyrotropin-releasing_hormone and bromoergocriptine on growth_hormone and prolactin secretion in perfused pituitary adenoma tissues of acromegaly .
1345574	0	growth_hormone	14,28	thyrotropin-releasing_hormone	70,99	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	levels|compound|START_ENTITY levels|acl|responding responding|nmod|END_ENTITY	Lower 24-hour growth_hormone levels in type I diabetics responding to thyrotropin-releasing_hormone -LRB- TRH -RRB- .
1355581	0	growth_hormone	58,72	thyrotropin-releasing_hormone	85,114	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|compound|START_ENTITY inhibition|nmod|response inhibition|acl|END_ENTITY	Corticotropin-releasing_hormone inhibition of paradoxical growth_hormone response to thyrotropin-releasing_hormone in insulin-dependent diabetics .
14551231	0	growth_hormone	35,49	thyrotropin-releasing_hormone	91,120	growth hormone	thyrotropin-releasing hormone	100356068(Tax:9986)	100346454(Tax:9986)	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Endocrine and metabolic effects of growth_hormone -LRB- GH -RRB- compared with GH-releasing peptide , thyrotropin-releasing_hormone , and insulin infusion in a rabbit model of prolonged critical_illness .
15595273	0	growth_hormone	14,28	thyrotropin-releasing_hormone	43,72	growth hormone	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|Pit-1 Pit-1|amod|END_ENTITY	Regulation of growth_hormone expression by thyrotropin-releasing_hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary .
1624675	0	growth_hormone	7,21	thyrotropin-releasing_hormone	182,211	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	START_ENTITY|advcl|corticotropin-releasing_hormone corticotropin-releasing_hormone|nmod|END_ENTITY	Plasma growth_hormone -LRB- GH -RRB- responses to corticotropin-releasing_hormone in patients with acromegaly -- the effect of dexamethasone pretreatment and the comparison with GH responses to thyrotropin-releasing_hormone , gonadotropin-releasing_hormone and GH-releasing_hormone .
1696695	0	growth_hormone	116,130	thyrotropin-releasing_hormone	143,172	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|nmod|hormone hormone|amod|END_ENTITY	The natural course of growth_hormone-secreting pituitary_adenomas after surgery alone -- clinical significance of the growth_hormone response to thyrotropin-releasing_hormone and luteinizing hormone-releasing hormone .
1902488	0	growth_hormone	24,38	thyrotropin-releasing_hormone	117,146	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	peptide|amod|START_ENTITY histidine_methionine|amod|peptide response|nmod|histidine_methionine response|dep|comparison comparison|nmod|effects effects|nmod|peptide peptide|amod|END_ENTITY	Paradoxical response of growth_hormone to peptide histidine_methionine in acromegaly : comparison with the effects of thyrotropin-releasing_hormone and vasoactive intestinal peptide .
2128417	0	growth_hormone	46,60	thyrotropin-releasing_hormone	100,129	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	levels|compound|START_ENTITY reduces|dobj|levels reduces|advcl|END_ENTITY	Triiodothyronine administration reduces serum growth_hormone levels and growth_hormone responses to thyrotropin-releasing_hormone in patients with anorexia_nervosa .
2494101	0	growth_hormone	106,120	thyrotropin-releasing_hormone	31,60	growth hormone	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Triiodothyronine inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in anesthetized chickens .
2572506	0	growth_hormone	102,116	thyrotropin-releasing_hormone	27,56	growth hormone	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Somatostatin inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in young and adult anesthetized chickens .
2862016	0	growth_hormone	54,68	thyrotropin-releasing_hormone	105,134	growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY suppression|nmod|secretion mediates|dobj|suppression mediates|nmod|END_ENTITY	Hypothalamic somatostatin mediates the suppression of growth_hormone secretion by centrally administered thyrotropin-releasing_hormone in conscious rats .
3085739	0	growth_hormone	21,35	thyrotropin-releasing_hormone	48,77	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|compound|START_ENTITY response|acl|END_ENTITY	Is there paradoxical growth_hormone response to thyrotropin-releasing_hormone in depression ?
3097564	0	growth_hormone	85,99	thyrotropin-releasing_hormone	22,51	growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY regulation|nmod|secretion participate|nmod|regulation participate|nsubj|evidence evidence|amod|END_ENTITY	Further evidence that thyrotropin-releasing_hormone participate in the regulation of growth_hormone secretion in the rat .
3101755	0	growth_hormone	28,42	thyrotropin-releasing_hormone	56,85	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Thyrotropin , prolactin , and growth_hormone responses to thyrotropin-releasing_hormone in anorexia_nervosa and bulimia .
3102991	0	growth_hormone	43,57	thyrotropin-releasing_hormone	10,39	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Effect of thyrotropin-releasing_hormone on growth_hormone release in normal subjects pretreated with human pancreatic growth_hormone-releasing factor 1-44 pulsatile administration .
3106949	0	growth_hormone	73,87	thyrotropin-releasing_hormone	33,62	growth hormone	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of orally administered thyrotropin-releasing_hormone on plasma growth_hormone , thyroid hormones , growth , feed efficiency , and organ weights of broiler_chickens .
3107300	0	growth_hormone	25,39	thyrotropin-releasing_hormone	61,90	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	secretion|amod|START_ENTITY mediation|nmod|secretion induced|nsubj|mediation induced|nmod|END_ENTITY	Cholinergic mediation of growth_hormone secretion induced by thyrotropin-releasing_hormone in cirrhotic patients .
3108068	0	growth_hormone	144,158	thyrotropin-releasing_hormone	93,122	growth hormone	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	secretion|amod|START_ENTITY stimulation|nmod|secretion stimulation|amod|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
3114818	0	growth_hormone	40,54	thyrotropin-releasing_hormone	67,96	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|compound|START_ENTITY psychological_stress|nmod|response Effect|nmod|psychological_stress Effect|acl|END_ENTITY	Effect of psychological_stress on human growth_hormone response to thyrotropin-releasing_hormone in normal controls .
3917270	0	growth_hormone	11,25	thyrotropin-releasing_hormone	126,155	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	secretion|amod|START_ENTITY Changes|nmod|secretion Changes|dep|comparison comparison|nmod|END_ENTITY	Changes in growth_hormone -LRB- GH -RRB- secretion induced by human pancreatic GH releasing hormone-44 in acromegaly : a comparison with thyrotropin-releasing_hormone and bromocriptine .
3923021	0	growth_hormone	146,160	thyrotropin-releasing_hormone	82,111	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Different responses of growth_hormone secretion to guanfacine , bromocriptine , and thyrotropin-releasing_hormone in acromegalic patients with pure growth_hormone -LRB- GH -RRB- - containing and mixed GH/prolactin-containing pituitary_adenomas .
3932951	0	growth_hormone	44,58	thyrotropin-releasing_hormone	71,100	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Thyroid-stimulating hormone , prolactin , and growth_hormone response to thyrotropin-releasing_hormone in treated children with congenital_hypothyroidism .
4007781	0	growth_hormone	15,29	thyrotropin-releasing_hormone	41,70	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	Stimulation|nmod|START_ENTITY release|nsubj|Stimulation release|nmod|END_ENTITY	Stimulation of growth_hormone release by thyrotropin-releasing_hormone in elderly subjects .
403195	0	growth_hormone	19,33	thyrotropin-releasing_hormone	51,80	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	levels|compound|START_ENTITY levels|nmod|injection injection|amod|END_ENTITY	Increase in plasma growth_hormone levels following thyrotropin-releasing_hormone injection in children with primary_hypothyroidism .
405552	0	growth_hormone	42,56	thyrotropin-releasing_hormone	69,98	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY hormones|nmod|response effect|nmod|hormones Lack|nmod|effect Lack|acl|END_ENTITY	Lack of effect of thyroid hormones on the growth_hormone response to thyrotropin-releasing_hormone in acromegaly .
406268	0	growth_hormone	68,82	thyrotropin-releasing_hormone	11,40	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	release|compound|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone on sleep and sleep-related growth_hormone release in normal subjects .
6244936	0	growth_hormone	147,161	thyrotropin-releasing_hormone	182,211	growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|acl|caused caused|nmod|END_ENTITY	Action of cholera toxin on hormone synthesis and release in GH cells : evidence that adenosine_3 ' ,5 ' - monophosphate does not mediate the decrease in growth_hormone synthesis caused by thyrotropin-releasing_hormone .
6422486	0	growth_hormone	21,35	thyrotropin-releasing_hormone	56,85	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|infusion infusion|amod|END_ENTITY	Diurnal variation of growth_hormone secretion following thyrotropin-releasing_hormone infusion in normal men .
6434581	0	growth_hormone	4,18	thyrotropin-releasing_hormone	31,60	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	The growth_hormone response to thyrotropin-releasing_hormone in insulin-dependent diabetics involves a cholinergic mechanism .
6773980	0	growth_hormone	10,24	thyrotropin-releasing_hormone	38,67	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Anomalous growth_hormone responses to thyrotropin-releasing_hormone and glucose in cirrhotic patients : the effect of metergoline .
6804479	0	growth_hormone	12,26	thyrotropin-releasing_hormone	30,59	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	Response|nmod|START_ENTITY Response|acl|END_ENTITY	Response of growth_hormone to thyrotropin-releasing_hormone during fetal life .
7569294	0	growth_hormone	26,40	thyrotropin-releasing_hormone	97,126	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	modulation|nmod|START_ENTITY stimulating|nsubj|modulation stimulating|xcomp|END_ENTITY	Cholinergic modulation of growth_hormone , prolactin and thyroid stimulating hormone responses to thyrotropin-releasing_hormone in normal aging .
7853798	0	growth_hormone	56,70	thyrotropin-releasing_hormone	74,103	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|nmod|START_ENTITY erythropoietin|nmod|responses Influence|nmod|erythropoietin Influence|acl|END_ENTITY	Influence of erythropoietin on paradoxical responses of growth_hormone to thyrotropin-releasing_hormone in uremic patients .
7885285	0	growth_hormone	45,59	thyrotropin-releasing_hormone	72,101	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|compound|START_ENTITY glucocorticoids|nmod|response Effect|nmod|glucocorticoids Effect|acl|END_ENTITY	Effect of glucocorticoids on the paradoxical growth_hormone response to thyrotropin-releasing_hormone in patients with acromegaly .
7991070	0	growth_hormone	124,138	thyrotropin-releasing_hormone	205,234	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	responses|compound|START_ENTITY mechanism|nmod|responses involvement|nmod|mechanism Lack|nmod|involvement Lack|dep|comparison comparison|nmod|responses responses|nmod|END_ENTITY	Lack of involvement of the cholinergic mechanism in vasoactive intestinal peptide - and peptide-histidine_methionine-induced growth_hormone -LRB- GH -RRB- responses in acromegaly : comparison with the GH responses to thyrotropin-releasing_hormone and GH-releasing_hormone .
8159113	0	growth_hormone	47,61	thyrotropin-releasing_hormone	74,103	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|compound|START_ENTITY status|nmod|response Influence|nmod|status Influence|acl|END_ENTITY	Influence of thyroid status on the paradoxical growth_hormone response to thyrotropin-releasing_hormone in human obesity .
816640	0	growth_hormone	15,29	thyrotropin-releasing_hormone	41,70	growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	Stimulation|nmod|START_ENTITY release|nsubj|Stimulation release|nmod|END_ENTITY	Stimulation of growth_hormone release by thyrotropin-releasing_hormone in the hypophysectomized rat bearing an ectopic pituitary .
819245	0	growth_hormone	71,85	thyrotropin-releasing_hormone	38,67	growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Stimulating and inhibiting effects of thyrotropin-releasing_hormone on growth_hormone release in rats .
819251	0	growth_hormone	53,67	thyrotropin-releasing_hormone	87,116	growth hormone	thyrotropin-releasing hormone	81668(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|compound|START_ENTITY hyperthyroidism|nmod|release Effects|nmod|hyperthyroidism induced|nsubj|Effects induced|nmod|END_ENTITY	Effects of hyperthyroidism and hypothyroidism on rat growth_hormone release induced by thyrotropin-releasing_hormone .
820711	0	growth_hormone	54,68	thyrotropin-releasing_hormone	15,44	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Suppression by thyrotropin-releasing_hormone -LRB- TRH -RRB- of growth_hormone release induced by arginine and insulin-induced hypoglycemia in man .
9675567	1	growth_hormone	53,67	thyrotropin-releasing_hormone	80,109	growth hormone	thyrotropin-releasing hormone	2688	7200	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	II : Paradoxical growth_hormone response to thyrotropin-releasing_hormone .
98725	0	growth_hormone	78,92	thyrotropin-releasing_hormone	14,43	growth hormone	thyrotropin-releasing hormone	378781(Tax:9031)	414344(Tax:9031)	Gene	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	The effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- and somatostatin -LRB- GHRIH -RRB- on growth_hormone and prolactin secretion in vitro and in vivo in the domestic fowl -LRB- Gallus_domesticus -RRB- .
2500677	0	growth_hormone	53,67	thyrotropin_releasing_hormone	81,110	growth hormone	thyrotropin releasing hormone	2688	7200	Gene	Gene	responses|amod|START_ENTITY responses|acl|END_ENTITY	Abnormal_thyroid stimulating hormone , prolactin , and growth_hormone responses to thyrotropin_releasing_hormone in abstinent alcoholic men with cerebral_atrophy .
7376785	0	growth_hormone	51,65	transferrin	38,49	growth hormone	transferrin	2688	7018	Gene	Gene	START_ENTITY|nsubj|relationship relationship|nmod|END_ENTITY	A possible relationship between serum transferrin , growth_hormone secretion and height velocity in children .
10970071	0	growth_hormone	53,67	vasoactive_intestinal_polypeptide	10,43	growth hormone	vasoactive intestinal polypeptide	2688	7432	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- release and cell morphology in human pituitary_adenoma_cell_cultures .
6120948	0	growth_hormone	47,61	vasoactive_intestinal_polypeptide	10,43	growth hormone	vasoactive intestinal polypeptide	2688	7432	Gene	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide on growth_hormone secretion in perifused acromegalic pituitary adenoma tissues .
15241820	0	growth_hormone-1	35,51	GH1	58,61	growth hormone-1	GH1	2688	2688	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms in the human growth_hormone-1 gene -LRB- GH1 -RRB- and the risk of breast_carcinoma .
3928732	0	growth_hormone-releasing_factor	15,46	GH	85,87	growth hormone-releasing factor	GH	2691	2688	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of growth_hormone-releasing_factor -LRB- GRF -RRB- and dopamine on growth_hormone -LRB- GH -RRB- secretion in acromegaly .
8020943	0	growth_hormone-releasing_factor	29,60	GHRF	67,71	growth hormone-releasing factor	GHRF	2691	2691	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic mapping of the human growth_hormone-releasing_factor gene -LRB- GHRF -RRB- using two intragenic polymorphisms detected by PCR amplification .
1974524	0	growth_hormone-releasing_factor	15,46	GRF	48,51	growth hormone-releasing factor	GRF	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- The effect of growth_hormone-releasing_factor -LRB- GRF -RRB- on secretion of insulin , glucagon and somatostatin from perfused rat pancreas -RSB- .
1977581	0	growth_hormone-releasing_factor	34,65	GRF	67,70	growth hormone-releasing factor	GRF	2691	2691	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Cysteamine-induced enhancement of growth_hormone-releasing_factor -LRB- GRF -RRB- immunoreactivity in arcuate neurons : morphological evidence for putative somatostatin/GRF interactions within hypothalamus .
2537185	0	growth_hormone-releasing_factor	12,43	GRF	45,48	growth hormone-releasing factor	GRF	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Blockade of growth_hormone-releasing_factor -LRB- GRF -RRB- activity in the pituitary and hypothalamus of the conscious rat with a peptidic GRF antagonist .
3095799	0	growth_hormone-releasing_factor	24,55	GRF	57,60	growth hormone-releasing factor	GRF	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of endogenous growth_hormone-releasing_factor -LRB- GRF -RRB- on the secretion of GH during the perinatal period in the rat .
1702174	0	growth_hormone-releasing_factor	34,65	Galanin	0,7	growth hormone-releasing factor	Galanin	29446(Tax:10116)	29141(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Galanin stimulates immunoreactive growth_hormone-releasing_factor secretion from rat hypothalamic slices perifused in vitro .
2906300	0	growth_hormone-releasing_factor	15,46	gastrin	117,124	growth hormone-releasing factor	gastrin	29446(Tax:10116)	25320(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|role role|nmod|END_ENTITY	Interaction of growth_hormone-releasing_factor and somatostatin on ulcer_healing_and_mucosal_growth in rats : role of gastrin and epidermal_growth_factor .
1474343	0	growth_hormone-releasing_factor	141,172	growth_hormone	33,47	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	delivery|nmod|START_ENTITY END_ENTITY|nmod|delivery	Restoration of juvenile baseline growth_hormone secretion with preservation of the ultradian growth_hormone rhythm by continuous delivery of growth_hormone-releasing_factor .
1474343	0	growth_hormone-releasing_factor	141,172	growth_hormone	93,107	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	delivery|nmod|START_ENTITY growth_hormone|nmod|delivery growth_hormone|nmod|preservation preservation|nmod|rhythm rhythm|compound|END_ENTITY	Restoration of juvenile baseline growth_hormone secretion with preservation of the ultradian growth_hormone rhythm by continuous delivery of growth_hormone-releasing_factor .
15367266	0	growth_hormone-releasing_factor	21,52	growth_hormone	78,92	growth hormone-releasing factor	growth hormone	281191(Tax:9913)	102406287	Gene	Gene	administration|amod|START_ENTITY administration|nmod|END_ENTITY	Effects of long-term growth_hormone-releasing_factor administration on plasma growth_hormone , luteinizing hormone and progesterone profiles in growing female buffaloes -LRB- Bubalus_bubalis -RRB- .
23015655	0	growth_hormone-releasing_factor	23,54	growth_hormone	86,100	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nmod|subjects subjects|nmod|secretion secretion|compound|END_ENTITY	Metabolic effects of a growth_hormone-releasing_factor in obese subjects with reduced growth_hormone secretion : a randomized controlled trial .
3020850	0	growth_hormone-releasing_factor	155,186	growth_hormone	91,105	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	administration|nmod|START_ENTITY re-instates|nmod|administration re-instates|dobj|responsiveness responsiveness|amod|END_ENTITY	Potentiation of cholinergic tone by pyridostigmine_bromide re-instates and potentiates the growth_hormone responsiveness to intermittent administration of growth_hormone-releasing_factor in man .
3085999	0	growth_hormone-releasing_factor	55,86	growth_hormone	23,37	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	hypoglycaemia|amod|START_ENTITY response|nmod|hypoglycaemia END_ENTITY|dobj|response	A divergence of plasma growth_hormone response between growth_hormone-releasing_factor and insulin-induced hypoglycaemia among middle-aged healthy male subjects .
3131855	0	growth_hormone-releasing_factor	38,69	growth_hormone	12,26	growth hormone-releasing factor	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	-LSB- Control of growth_hormone release by growth_hormone-releasing_factor and prostaglandin_E2 in a system of perfused rat anterior pituitary cells -RSB- .
3160962	0	growth_hormone-releasing_factor	101,132	growth_hormone	23,37	growth hormone-releasing factor	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|secretion secretion|nmod|END_ENTITY	Pituitary secretion of growth_hormone in response to opioid peptides and opiates is mediated through growth_hormone-releasing_factor .
3919137	0	growth_hormone-releasing_factor	45,76	growth_hormone	131,145	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	Administration|nmod|START_ENTITY sustains|nsubj|Administration sustains|dobj|concentrations concentrations|nmod|END_ENTITY	Administration of synthetic human pancreatic growth_hormone-releasing_factor for five days sustains raised serum concentrations of growth_hormone in steers .
3930225	0	growth_hormone-releasing_factor	64,95	growth_hormone	7,21	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	infusion|amod|START_ENTITY responses|nmod|infusion responses|amod|END_ENTITY	Plasma growth_hormone and somatomedin-C responses to continuous growth_hormone-releasing_factor infusion in normal adult men .
6409919	0	growth_hormone-releasing_factor	25,56	growth_hormone	84,98	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Synthetic human pancreas growth_hormone-releasing_factor -LRB- hpGRF1-44-NH2 -RRB- stimulates growth_hormone secretion in normal men .
6415487	0	growth_hormone-releasing_factor	64,95	growth_hormone	30,44	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Transcriptional regulation of growth_hormone gene expression by growth_hormone-releasing_factor .
7587172	0	growth_hormone-releasing_factor	158,189	growth_hormone	107,121	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	administration|amod|START_ENTITY circulating|nmod|administration circulating|dobj|concentration concentration|amod|END_ENTITY	Effect of dietary energy intake and exogenous porcine growth_hormone administration on circulating porcine growth_hormone concentration and response to human growth_hormone-releasing_factor administration in growing swine .
7587172	0	growth_hormone-releasing_factor	158,189	growth_hormone	54,68	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	administration|amod|START_ENTITY circulating|nmod|administration porcine|advcl|circulating porcine|dobj|administration administration|amod|END_ENTITY	Effect of dietary energy intake and exogenous porcine growth_hormone administration on circulating porcine growth_hormone concentration and response to human growth_hormone-releasing_factor administration in growing swine .
9303474	0	growth_hormone-releasing_factor	69,100	growth_hormone	34,48	growth hormone-releasing factor	growth hormone	2691	2688	Gene	Gene	effects|nmod|START_ENTITY Evidence|dep|effects Evidence|nmod|role role|nmod|END_ENTITY	Evidence for a mammogenic role of growth_hormone in ewes : effects of growth_hormone-releasing_factor during artificial induction of lactation .
10624798	0	growth_hormone-releasing_factor_receptor	42,82	insulin-like_growth_factor-I	10,38	growth hormone-releasing factor receptor	insulin-like growth factor-I	25321(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of insulin-like_growth_factor-I on growth_hormone-releasing_factor_receptor expression in primary rat anterior pituitary cell culture .
2565342	0	growth_hormone-releasing_hormone	71,103	Dipeptidylpeptidase_IV	0,22	growth hormone-releasing hormone	Dipeptidylpeptidase IV	2691	1803	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Dipeptidylpeptidase_IV and trypsin-like enzymatic degradation of human growth_hormone-releasing_hormone in plasma .
14746863	0	growth_hormone-releasing_hormone	15,47	GH-RH	49,54	growth hormone-releasing hormone	GH-RH	2691	2691	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Antagonists of growth_hormone-releasing_hormone -LRB- GH-RH -RRB- enhance tumour growth inhibition induced by androgen deprivation in human MDA-Pca-2b prostate_cancers .
3089538	0	growth_hormone-releasing_hormone	29,61	GH-RH	63,68	growth hormone-releasing hormone	GH-RH	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	The hypothalamo-infundibular growth_hormone-releasing_hormone -LRB- GH-RH -RRB- system of the rat .
12740741	0	growth_hormone-releasing_hormone	26,58	GHRH	60,64	growth hormone-releasing hormone	GHRH	2691	2691	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of endogenous growth_hormone-releasing_hormone -LRB- GHRH -RRB- in the exercise-related response of growth_hormone .
20509930	0	growth_hormone-releasing_hormone	28,60	GHRH	62,66	growth hormone-releasing hormone	GHRH	2691	2691	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Antiproliferative effect of growth_hormone-releasing_hormone -LRB- GHRH -RRB- antagonist on ovarian_cancer cells through the EGFR-Akt pathway .
21854358	0	growth_hormone-releasing_hormone	25,57	GHRH	59,63	growth hormone-releasing hormone	GHRH	2691	2691	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Antineoplastic action of growth_hormone-releasing_hormone -LRB- GHRH -RRB- antagonists .
2551950	0	growth_hormone-releasing_hormone	11,43	GHRH	45,49	growth hormone-releasing hormone	GHRH	2691	2691	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of growth_hormone-releasing_hormone -LRB- GHRH -RRB- on densely granulated somatotroph_adenomas and sparsely granulated somatotroph_adenomas in vitro : a morphological and functional investigation .
8032940	0	growth_hormone-releasing_hormone	40,72	GHRH	74,78	growth hormone-releasing hormone	GHRH	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Alterations of adenylyl cyclase-coupled growth_hormone-releasing_hormone -LRB- GHRH -RRB- pituitary receptors in different conditions of GHRH deprivation .
8745060	0	growth_hormone-releasing_hormone	20,52	GHRH	54,58	growth hormone-releasing hormone	GHRH	2691	2691	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of growth_hormone-releasing_hormone -LRB- GHRH -RRB- binding to cloned porcine_GHRH_receptor .
21777303	0	growth_hormone-releasing_hormone	97,129	Ghrelin	0,7	growth hormone-releasing hormone	Ghrelin	14601(Tax:10090)	58991(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Ghrelin and obestatin_modulate growth_hormone-releasing_hormone release and synaptic inputs onto growth_hormone-releasing_hormone neurons .
11251367	0	growth_hormone-releasing_hormone	29,61	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	stimulation|amod|START_ENTITY response|nmod|stimulation response|amod|END_ENTITY	Growth_hormone response to a growth_hormone-releasing_hormone stimulation test in a population-based study following cranial irradiation of childhood brain_tumors .
14642012	0	growth_hormone-releasing_hormone	27,59	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone and clonidine in young monkeys : correlation with behavioral characteristics .
15705990	0	growth_hormone-releasing_hormone	27,59	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone is reduced in adult asthmatic patients receiving long-term inhaled corticosteroid treatment .
2126361	0	growth_hormone-releasing_hormone	28,60	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	hypoglycemia|amod|START_ENTITY END_ENTITY|nmod|hypoglycemia	Growth_hormone responses to growth_hormone-releasing_hormone , clonidine and insulin-induced hypoglycemia in normal weight bulimic women .
2501967	0	growth_hormone-releasing_hormone	37,69	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	infusion|amod|START_ENTITY END_ENTITY|nmod|infusion	Growth_hormone response to overnight growth_hormone-releasing_hormone infusion and oral pyridostigmine in children with short_stature .
2513890	0	growth_hormone-releasing_hormone	38,70	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	release|xcomp|START_ENTITY release|nsubj|END_ENTITY	Growth_hormone release in response to growth_hormone-releasing_hormone in term and preterm neonates .
2866496	0	growth_hormone-releasing_hormone	28,60	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	responses|acl|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone -LRB- 1-29 -RRB- - NH2 and a D-Ala2 analog in normal men .
3100110	0	growth_hormone-releasing_hormone	58,90	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	pretreatment|nmod|START_ENTITY pretreatment|amod|END_ENTITY	Growth_hormone pretreatment in man blocks the response to growth_hormone-releasing_hormone ; evidence for a direct effect of growth_hormone .
3117453	0	growth_hormone-releasing_hormone	38,70	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	hyperresponsiveness|xcomp|START_ENTITY hyperresponsiveness|nsubj|END_ENTITY	Growth_hormone hyperresponsiveness to growth_hormone-releasing_hormone in patients with severe liver_cirrhosis .
3144116	0	growth_hormone-releasing_hormone	27,59	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- hp GHRH1-44 -RRB- as an index of growth_hormone secretory dysfunction after prophylactic cranial irradiation for acute_lymphoblastic_leukemia -LRB- 24 grays -RRB- .
3149734	0	growth_hormone-releasing_hormone	29,61	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression END_ENTITY|dobj|regulation	Growth_hormone regulation of growth_hormone-releasing_hormone gene expression .
3924946	0	growth_hormone-releasing_hormone	52,84	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	infusions|nmod|START_ENTITY END_ENTITY|nmod|infusions	Growth_hormone responses to continuous infusions of growth_hormone-releasing_hormone .
7761697	0	growth_hormone-releasing_hormone	28,60	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	485863(Tax:9615)	403795(Tax:9615)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and clonidine in dogs with Cushing 's _ syndrome .
7788012	0	growth_hormone-releasing_hormone	27,59	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- , insulin , clonidine and arginine after GHRH pretreatment in obese children : evidence of somatostatin increase ?
7926116	0	growth_hormone-releasing_hormone	27,59	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	Growth_hormone response to growth_hormone-releasing_hormone stimulation in oligozoospermic patients .
8136894	0	growth_hormone-releasing_hormone	62,94	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	studies|nmod|START_ENTITY secretion|dep|studies secretion|amod|END_ENTITY	Growth_hormone secretion in Alzheimer 's _ disease : studies with growth_hormone-releasing_hormone alone and combined with pyridostigmine or arginine .
8762731	0	growth_hormone-releasing_hormone	28,60	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and clonidine in patients with type_I_diabetes and in normal controls : effect of age , body mass index and sex .
8810733	0	growth_hormone-releasing_hormone	27,59	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone varies with the hypothalamic-pituitary_abnormalities .
9518881	0	growth_hormone-releasing_hormone	28,60	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	485863(Tax:9615)	403795(Tax:9615)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and hexarelin in fed and fasted dogs : effect of somatostatin infusion or pretreatment with pirenzepine .
9925180	0	growth_hormone-releasing_hormone	27,59	Growth_hormone	0,14	growth hormone-releasing hormone	Growth hormone	2691	2688	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	Growth_hormone response to growth_hormone-releasing_hormone stimulation in obsessive-compulsive_disorder .
25283153	0	growth_hormone-releasing_hormone	22,54	Pro1	65,69	growth hormone-releasing hormone	Pro1	2691	4000	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Identification of the growth_hormone-releasing_hormone analogue -LSB- Pro1 , Val14 -RSB- - hGHRH with an incomplete C-term amidation in a confiscated product .
10521035	0	growth_hormone-releasing_hormone	91,123	growth_hormone	64,78	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	Predicting|nmod|START_ENTITY Predicting|dobj|performance performance|nmod|response response|amod|END_ENTITY	Predicting bull growth performance and carcass composition from growth_hormone response to growth_hormone-releasing_hormone .
10594518	0	growth_hormone-releasing_hormone	33,65	growth_hormone	125,139	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The relative roles of continuous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- and intermittent somatostatin -LRB- 1-14 -RRB- -LRB- SS -RRB- in growth_hormone -LRB- GH -RRB- pulse generation : studies in normal and post cranial irradiated individuals .
11291426	0	growth_hormone-releasing_hormone	16,48	growth_hormone	79,93	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Contribution of growth_hormone-releasing_hormone and somatostatin to decreased growth_hormone secretion in elderly men .
11882517	0	growth_hormone-releasing_hormone	55,87	growth_hormone	10,24	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	resistance|amod|START_ENTITY persists|nmod|resistance persists|nsubj|secretion secretion|compound|END_ENTITY	Pulsatile growth_hormone secretion persists in genetic growth_hormone-releasing_hormone resistance .
12413983	0	growth_hormone-releasing_hormone	80,112	growth_hormone	53,67	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	Effect|acl|START_ENTITY Effect|nmod|blockade blockade|nmod|response response|compound|END_ENTITY	Effect of the opioid blockade on the feeding-induced growth_hormone response to growth_hormone-releasing_hormone in women with polycystic_ovary_syndrome .
12740741	0	growth_hormone-releasing_hormone	26,58	growth_hormone	102,116	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|response response|nmod|END_ENTITY	Involvement of endogenous growth_hormone-releasing_hormone -LRB- GHRH -RRB- in the exercise-related response of growth_hormone .
1311892	0	growth_hormone-releasing_hormone	57,89	growth_hormone	30,44	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	effect|acl|START_ENTITY effect|nmod|atenolol atenolol|nmod|response response|amod|END_ENTITY	The effect of atenolol on the growth_hormone response to growth_hormone-releasing_hormone in obese children .
1347904	0	growth_hormone-releasing_hormone	35,67	growth_hormone	88,102	growth hormone-releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of passive immunization of growth_hormone-releasing_hormone and somatostatin on growth_hormone secretion under conditions of high somatostatin tone .
1385023	0	growth_hormone-releasing_hormone	59,91	growth_hormone	23,37	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	administration|amod|START_ENTITY reinstates|nmod|administration reinstates|dobj|response response|amod|END_ENTITY	Galanin reinstates the growth_hormone response to repeated growth_hormone-releasing_hormone administration in man .
1499577	0	growth_hormone-releasing_hormone	20,52	growth_hormone	102,116	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	test|amod|START_ENTITY value|nmod|test value|nmod|deficiency deficiency|compound|END_ENTITY	Diagnostic value of growth_hormone-releasing_hormone test in children and adolescents with idiopathic growth_hormone deficiency .
15155578	0	growth_hormone-releasing_hormone	38,70	growth_hormone	101,115	growth hormone-releasing hormone	growth hormone	14601(Tax:10090)	14599(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY ablation|nmod|gene mouse|nmod|ablation mouse|dep|model model|nmod|deficiency deficiency|compound|END_ENTITY	A mouse with targeted ablation of the growth_hormone-releasing_hormone gene : a new model of isolated growth_hormone deficiency .
15240610	0	growth_hormone-releasing_hormone	189,221	growth_hormone	16,30	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	secretion|nmod|START_ENTITY increase|nmod|secretion evidence|nmod|increase Augmentation|dep|evidence Augmentation|nmod|secretion secretion|amod|END_ENTITY	Augmentation of growth_hormone secretion after testosterone treatment in boys with constitutional delay of growth and adolescence : evidence against an increase in hypothalamic secretion of growth_hormone-releasing_hormone .
1865077	0	growth_hormone-releasing_hormone	46,78	growth_hormone	19,33	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	differences|nmod|START_ENTITY differences|nmod|response response|amod|END_ENTITY	Sex differences in growth_hormone response to growth_hormone-releasing_hormone .
1983729	0	growth_hormone-releasing_hormone	26,58	growth_hormone	70,84	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	effects|amod|START_ENTITY modulation|nmod|effects modulation|nmod|secretion secretion|amod|END_ENTITY	Cholinergic modulation of growth_hormone-releasing_hormone effects on growth_hormone secretion in dementia .
19912928	0	growth_hormone-releasing_hormone	8,40	growth_hormone	112,126	growth hormone-releasing hormone	growth hormone	14601(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Altered growth_hormone-releasing_hormone mRNA expression in transgenic_mice with excess_or_deficient endogenous growth_hormone .
2023538	0	growth_hormone-releasing_hormone	74,106	growth_hormone	47,61	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	modulating|advcl|START_ENTITY modulating|dobj|response response|amod|END_ENTITY	The role of cholinergic tone in modulating the growth_hormone response to growth_hormone-releasing_hormone in normal man .
2106092	0	growth_hormone-releasing_hormone	26,58	growth_hormone	151,165	growth hormone-releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	Depletion|nmod|START_ENTITY reveals|nsubj|Depletion reveals|nmod|secretion secretion|amod|END_ENTITY	Depletion of hypothalamic growth_hormone-releasing_hormone by neonatal monosodium_glutamate treatment reveals an inhibitory effect of betamethasone on growth_hormone secretion in adult rats .
2107653	0	growth_hormone-releasing_hormone	65,97	growth_hormone	38,52	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	effects|acl|START_ENTITY effects|nmod|cortisone_acetate cortisone_acetate|nmod|response response|amod|END_ENTITY	Acute effects of cortisone_acetate on growth_hormone response to growth_hormone-releasing_hormone in normal adult subjects .
2118535	0	growth_hormone-releasing_hormone	66,98	growth_hormone	110,124	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Pyridostigmine blocks the inhibitory effect of glucocorticoids on growth_hormone-releasing_hormone stimulated growth_hormone secretion in normal man .
2118536	0	growth_hormone-releasing_hormone	94,126	growth_hormone	10,24	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	infusion|amod|START_ENTITY effects|nmod|infusion secretion|dep|effects secretion|compound|END_ENTITY	Pulsatile growth_hormone secretion in patients with acromegaly and normal men : the effects of growth_hormone-releasing_hormone infusion .
2463192	0	growth_hormone-releasing_hormone	138,170	growth_hormone	14,28	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	induced|nmod|START_ENTITY activation|acl|induced involved|nmod|activation interactions|acl|involved Regulation|dep|interactions Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of growth_hormone secretion and cyclic_AMP metabolism in ovine pituitary cells : interactions involved in activation induced by growth_hormone-releasing_hormone and phorbol_esters .
2506218	0	growth_hormone-releasing_hormone	11,43	growth_hormone	83,97	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	administration|amod|START_ENTITY restores|nsubj|administration restores|dobj|response response|amod|END_ENTITY	Repetitive growth_hormone-releasing_hormone administration restores the attenuated growth_hormone -LRB- GH -RRB- response to GH-releasing hormone testing in normal aging .
2546369	0	growth_hormone-releasing_hormone	31,63	growth_hormone	102,116	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	infusions|nsubj|START_ENTITY infusions|ccomp|augment augment|dobj|secretion secretion|amod|END_ENTITY	Use of continuous subcutaneous growth_hormone-releasing_hormone -LRB- GHRH -LRB- 1-29 -RRB- NH2 -RRB- infusions to augment growth_hormone secretion and to promote growth .
3100110	0	growth_hormone-releasing_hormone	58,90	growth_hormone	124,138	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	pretreatment|nmod|START_ENTITY pretreatment|dep|evidence evidence|nmod|effect effect|nmod|END_ENTITY	Growth_hormone pretreatment in man blocks the response to growth_hormone-releasing_hormone ; evidence for a direct effect of growth_hormone .
3114305	0	growth_hormone-releasing_hormone	53,85	growth_hormone	26,40	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	Effects|acl|START_ENTITY Effects|nmod|sex sex|nmod|response response|amod|END_ENTITY	Effects of sex and age on growth_hormone response to growth_hormone-releasing_hormone in healthy individuals .
3116798	0	growth_hormone-releasing_hormone	45,77	growth_hormone	18,32	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	difference|acl|START_ENTITY difference|nmod|response response|amod|END_ENTITY	Sex difference in growth_hormone response to growth_hormone-releasing_hormone between pubertal tall girls and boys .
3117450	0	growth_hormone-releasing_hormone	104,136	growth_hormone	77,91	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	affect|nmod|START_ENTITY affect|dobj|response response|amod|END_ENTITY	Stilboestrol pretreatment of children with short stature does not affect the growth_hormone response to growth_hormone-releasing_hormone .
3135287	0	growth_hormone-releasing_hormone	11,43	growth_hormone	62,76	growth hormone-releasing hormone	growth hormone	281191(Tax:9913)	2688	Gene	Gene	Analogs|nmod|START_ENTITY induce|nsubj|Analogs induce|dobj|release release|nmod|END_ENTITY	Analogs of growth_hormone-releasing_hormone induce release of growth_hormone in the bovine .
3144116	0	growth_hormone-releasing_hormone	27,59	growth_hormone	89,103	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|nmod|index index|nmod|dysfunction dysfunction|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- hp GHRH1-44 -RRB- as an index of growth_hormone secretory dysfunction after prophylactic cranial irradiation for acute_lymphoblastic_leukemia -LRB- 24 grays -RRB- .
3145297	0	growth_hormone-releasing_hormone	112,144	growth_hormone	72,86	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	influence|nmod|START_ENTITY influence|nmod|administration administration|nmod|response response|amod|END_ENTITY	Inhibitory influence of thyrotropin_releasing_hormone administration on growth_hormone response to low doses of growth_hormone-releasing_hormone in normal man .
7486404	0	growth_hormone-releasing_hormone	43,75	growth_hormone	91,105	growth hormone-releasing hormone	growth hormone	780526(Tax:9940)	443329(Tax:9940)	Gene	Gene	stimulation|amod|START_ENTITY infusion|nmod|stimulation Effects|nmod|infusion Effects|nmod|release release|amod|END_ENTITY	Effects of short-term cortisol infusion on growth_hormone-releasing_hormone stimulation of growth_hormone release in sheep .
8112716	0	growth_hormone-releasing_hormone	96,128	growth_hormone	27,41	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	stimulation|amod|START_ENTITY specificity|nmod|stimulation Variability|dep|specificity Variability|nmod|levels levels|compound|END_ENTITY	Variability of serum human growth_hormone levels in different commercial assays : specificity of growth_hormone-releasing_hormone stimulation .
8187302	0	growth_hormone-releasing_hormone	109,141	growth_hormone	91,105	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	enhances|xcomp|START_ENTITY enhances|dobj|responses responses|nmod|END_ENTITY	Octreotide administration , under particular temporal conditions , enhances the responses of growth_hormone to growth_hormone-releasing_hormone in normal subjects .
8255393	0	growth_hormone-releasing_hormone	31,63	growth_hormone	105,119	growth hormone-releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY decrease|nmod|expression decrease|dep|mechanism mechanism|nmod|levels levels|amod|END_ENTITY	Obesity-associated decrease in growth_hormone-releasing_hormone gene expression : a mechanism for reduced growth_hormone mRNA levels in genetically obese Zucker rats .
8258646	0	growth_hormone-releasing_hormone	46,78	growth_hormone	19,33	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	Variability|dep|START_ENTITY Variability|nmod|response response|amod|END_ENTITY	Variability in the growth_hormone response to growth_hormone-releasing_hormone alone or combined with pyridostigmine in type 1 diabetic patients .
8370132	0	growth_hormone-releasing_hormone	78,110	growth_hormone	21,35	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	pathways|nmod|START_ENTITY stimulates|nmod|pathways stimulates|dobj|secretion secretion|amod|END_ENTITY	Melatonin stimulates growth_hormone secretion through pathways other than the growth_hormone-releasing_hormone .
8370135	0	growth_hormone-releasing_hormone	102,134	growth_hormone	75,89	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Protein intake during aggressive calorie restriction in obesity determines growth_hormone response to growth_hormone-releasing_hormone after weight_loss .
8622602	0	growth_hormone-releasing_hormone	76,108	growth_hormone	49,63	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Long-term administration of acipimox potentiates growth_hormone response to growth_hormone-releasing_hormone by decreasing serum free fatty_acid in obesity .
8921823	0	growth_hormone-releasing_hormone	100,132	growth_hormone	42,56	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	responsiveness|xcomp|START_ENTITY inhibits|ccomp|responsiveness inhibits|nsubj|administration administration|nmod|END_ENTITY	Acute administration of recombinant human growth_hormone inhibits the somatotrope responsiveness to growth_hormone-releasing_hormone in childhood .
8980159	0	growth_hormone-releasing_hormone	67,99	growth_hormone	23,37	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	plus|amod|START_ENTITY stimulation|nmod|plus response|nmod|stimulation response|amod|END_ENTITY	Reproducibility of the growth_hormone response to stimulation with growth_hormone-releasing_hormone plus arginine during lifespan .
9086339	0	growth_hormone-releasing_hormone	74,106	growth_hormone	33,47	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	stimulation|amod|START_ENTITY valerate|nmod|stimulation valerate|nmod|response response|compound|END_ENTITY	Effects of estradiol valerate on growth_hormone and prolactin response to growth_hormone-releasing_hormone stimulation in pre - and postmenopausal women .
9231053	0	growth_hormone-releasing_hormone	62,94	growth_hormone	31,45	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|deficiency deficiency|compound|END_ENTITY	Treatment of radiation-induced growth_hormone deficiency with growth_hormone-releasing_hormone .
9494699	0	growth_hormone-releasing_hormone	86,118	growth_hormone	59,73	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	Effects|acl|START_ENTITY Effects|nmod|agonists agonists|nmod|response response|amod|END_ENTITY	Effects of beta-adrenergic agonists and antagonists on the growth_hormone response to growth_hormone-releasing_hormone in anorexia_nervosa .
9930632	0	growth_hormone-releasing_hormone	136,168	growth_hormone	198,212	growth hormone-releasing hormone	growth hormone	2691	2688	Gene	Gene	resistance|amod|START_ENTITY central|nmod|resistance central|xcomp|END_ENTITY	Growth_hormone-insulin-like_growth_factor-I_axis in adult insulin-dependent diabetic patients : evidence for central hypersensitivity to growth_hormone-releasing_hormone and peripheral resistance to growth_hormone .
1954904	0	growth_hormone-releasing_hormone	22,54	hGRH	56,60	growth hormone-releasing hormone	hGRH	2691	2796	Gene	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|appos|END_ENTITY	Biosynthesis of human growth_hormone-releasing_hormone -LRB- hGRH -RRB- in the pituitary of hGRH transgenic_mice .
15003714	0	growth_hormone-releasing_hormone	10,42	interferon-gamma	83,99	growth hormone-releasing hormone	interferon-gamma	2691	3458	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of growth_hormone-releasing_hormone -LRB- GHRH -RRB- and GHRH antagonist -LRB- MZ-4-71 -RRB- on interferon-gamma secretion from human peripheral blood mononuclear cells in vitro .
23280565	0	growth_hormone-releasing_hormone	47,79	luteinizing_hormone-releasing_hormone	99,136	growth hormone-releasing hormone	luteinizing hormone-releasing hormone	2691	25194(Tax:10116)	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|nmod|END_ENTITY	Mechanisms of synergism between antagonists of growth_hormone-releasing_hormone and antagonists of luteinizing_hormone-releasing_hormone in shrinking experimental benign_prostatic_hyperplasia .
3131150	0	growth_hormone-releasing_hormone	11,43	thyrotropin-releasing_hormone	98,127	growth hormone-releasing hormone	thyrotropin-releasing hormone	29446(Tax:10116)	25569(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Effects of growth_hormone-releasing_hormone and corticotropin-releasing_hormone on the release of thyrotropin-releasing_hormone from the rat hypothalamus in vitro .
16469800	0	growth_hormone-releasing_hormone_receptor	30,71	GHRH-R	73,79	growth hormone-releasing hormone receptor	GHRH-R	420385(Tax:9031)	420385(Tax:9031)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Identification of the chicken growth_hormone-releasing_hormone_receptor -LRB- GHRH-R -RRB- mRNA and gene : regulation of anterior pituitary GHRH-R mRNA levels by homologous and heterologous hormones .
16326834	0	growth_hormone-releasing_hormone_receptor	47,88	pit-1	12,17	growth hormone-releasing hormone receptor	pit-1	25321(Tax:10116)	25517(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of pit-1 in the regulation of the rat growth_hormone-releasing_hormone_receptor gene transcription by glucocorticoids .
16959872	0	growth_hormone-releasing_peptide	2,34	CD36	65,69	growth hormone-releasing peptide	CD36	58991(Tax:10090)	12491(Tax:10090)	Gene	Gene	START_ENTITY|acl:relcl|binds binds|dobj|END_ENTITY	A growth_hormone-releasing_peptide that binds scavenger receptor CD36 and ghrelin_receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome_proliferator-activated_receptor_gamma-dependent pathway .
17138655	0	growth_hormone-releasing_peptide	2,34	CD36	129,133	growth hormone-releasing peptide	CD36	58991(Tax:10090)	12491(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	A growth_hormone-releasing_peptide promotes mitochondrial biogenesis and a fat burning-like phenotype through scavenger receptor CD36 in white adipocytes .
12655557	0	growth_hormone_1	23,39	GH1	41,44	growth hormone 1	GH1	24391(Tax:10116)	24391(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations of the growth_hormone_1 -LRB- GH1 -RRB- gene disclosed by modulation of the clinical selection criteria for individuals with short_stature .
16322331	0	growth_hormone_1	57,73	GH1	75,78	growth hormone 1	GH1	2688	2688	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of polymorphisms and haplotypes in the human growth_hormone_1 -LRB- GH1 -RRB- gene with breast_cancer .
9256367	0	growth_hormone_binding_protein	72,102	growth_hormone_receptor	20,43	growth hormone binding protein	growth hormone receptor	2690	2690	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human growth_hormone_receptor gene transcription by human growth_hormone_binding_protein .
24725418	0	growth_hormone_receptor	12,35	GH-R	37,41	growth hormone receptor	GH-R	100860790	100860790	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Presence of growth_hormone_receptor -LRB- GH-R -RRB- mRNA and protein in goat ovarian follicles and improvement of in vitro preantral follicle survival and development with GH .
12199334	0	growth_hormone_receptor	65,88	GHR	95,98	growth hormone receptor	GHR	2690	2690	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel mutation involving the translation initiation codon of the growth_hormone_receptor gene -LRB- GHR -RRB- in a patient with Laron_syndrome .
16278515	0	growth_hormone_receptor	61,84	GHR	86,89	growth hormone receptor	GHR	2690	2690	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in exon 10 of the chinchilla growth_hormone_receptor -LRB- GHR -RRB- gene .
17044257	0	growth_hormone_receptor	62,85	GHR	87,90	growth hormone receptor	GHR	280805(Tax:9913)	280805(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular evolution of coding and non-coding sequences of the growth_hormone_receptor -LRB- GHR -RRB- gene in the family Bovidae .
20105189	0	growth_hormone_receptor	20,43	GHR	45,48	growth hormone receptor	GHR	2690	2690	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations of the growth_hormone_receptor -LRB- GHR -RRB- gene polymorphisms with adiposity and IGF-I activity in adolescents .
21386799	0	growth_hormone_receptor	6,29	GHR	31,34	growth hormone receptor	GHR	2690	2690	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Human growth_hormone_receptor -LRB- GHR -RRB- expression in obesity : II .
21386804	0	growth_hormone_receptor	6,29	GHR	31,34	growth hormone receptor	GHR	2690	2690	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Human growth_hormone_receptor -LRB- GHR -RRB- expression in obesity : I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women .
25552351	0	growth_hormone_receptor	13,36	GHR	38,41	growth hormone receptor	GHR	2690	2690	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of growth_hormone_receptor -LRB- GHR -RRB- exon 3 and -202 A/C IGFBP-3 genetic polymorphisms on clinical and biochemical features and therapeutic outcome of patients with acromegaly .
10996429	0	growth_hormone_receptor	25,48	Growth_hormone	0,14	growth hormone receptor	Growth hormone	2690	2688	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Growth_hormone regulates growth_hormone_receptor gene transcription in primary human thyroid cells .
25101218	0	growth_hormone_receptor	20,43	JAK2	58,62	growth hormone receptor	JAK2	2690	3717	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	A new mechanism for growth_hormone_receptor activation of JAK2 , and implications for related cytokine receptors .
22781587	0	growth_hormone_receptor	39,62	Let-7b	0,6	growth hormone receptor	Let-7b	107049315	777926(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Let-7b regulates the expression of the growth_hormone_receptor gene in deletion-type dwarf chickens .
9733777	0	growth_hormone_receptor	62,85	MSY-1	21,26	growth hormone receptor	MSY-1	14600(Tax:10090)	22608(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor MSY-1 regulates expression of the murine growth_hormone_receptor gene .
7678333	0	growth_hormone_receptor	32,55	granulocyte_colony-stimulating_factor_receptor	92,138	growth hormone receptor	granulocyte colony-stimulating factor receptor	14600(Tax:10090)	12986(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Signal transduction mediated by growth_hormone_receptor and its chimeric molecules with the granulocyte_colony-stimulating_factor_receptor .
11404009	0	growth_hormone_receptor	31,54	growth_hormone	97,111	growth hormone receptor	growth hormone	2690	2688	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of a teleost growth_hormone_receptor and its functional interaction with human growth_hormone .
9256367	0	growth_hormone_receptor	20,43	growth_hormone_binding_protein	72,102	growth hormone receptor	growth hormone binding protein	2690	2690	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of human growth_hormone_receptor gene transcription by human growth_hormone_binding_protein .
10503994	0	growth_hormone_receptor	54,77	hGHR	79,83	growth hormone receptor	hGHR	2690	2690	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Selective amplification of exons 3 and 8 of the human growth_hormone_receptor -LRB- hGHR -RRB- gene based on newly identified intron sequences .
19116246	0	growth_hormone_receptor	36,59	hGHR	61,65	growth hormone receptor	hGHR	2690	2690	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and activity of the human growth_hormone_receptor -LRB- hGHR -RRB- gene V2 promoter .
18758711	0	growth_hormone_receptor	54,77	leptin	130,136	growth hormone receptor	leptin	397488(Tax:9823)	396832(Tax:9823)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant growth hormone on expression of growth_hormone_receptor , insulin-like growth factor mRNA and serum level of leptin in growing pigs .
4570040	0	growth_hormone_releasing_factor	23,54	GH-RF	56,61	growth hormone releasing factor	GH-RF	29446(Tax:10116)	29446(Tax:10116)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Enzymatic synthesis of growth_hormone_releasing_factor -LRB- GH-RF -RRB- by rat incubates and by extracts of rat and porcine hypothalamic tissue .
2871950	0	growth_hormone_releasing_factor	62,93	Growth_hormone	0,14	growth hormone releasing factor	Growth hormone	2691	2688	Gene	Gene	injections|nmod|START_ENTITY dose|nmod|injections END_ENTITY|nmod|dose	Growth_hormone response to low dose intravenous injections of growth_hormone_releasing_factor in obese and normal weight women .
2893766	0	growth_hormone_releasing_factor	62,93	Growth_hormone	0,14	growth hormone releasing factor	Growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|amod|END_ENTITY	Growth_hormone secretion during pregnancy : altered effects of growth_hormone_releasing_factor and insulin-like_growth_factor-I in vitro .
7903898	0	growth_hormone_releasing_factor	75,106	Insulin-like_growth_factor_I	0,28	growth hormone releasing factor	Insulin-like growth factor I	29446(Tax:10116)	24482(Tax:10116)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Insulin-like_growth_factor_I modulates hypothalamic somatostatin through a growth_hormone_releasing_factor increased somatostatin release and messenger ribonucleic_acid levels .
1296432	0	growth_hormone_releasing_factor	47,78	growth_hormone	82,96	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Defective response of plasma growth_hormone to growth_hormone_releasing_factor in growth_hormone deficient children .
1678494	0	growth_hormone_releasing_factor	45,76	growth_hormone	12,26	growth hormone releasing factor	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|Dynamics Dynamics|nmod|END_ENTITY	Dynamics of growth_hormone responsiveness to growth_hormone_releasing_factor in aging rats : peripheral and central influences .
2678528	0	growth_hormone_releasing_factor	66,97	growth_hormone	35,49	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	-RSB-|compound|START_ENTITY using|dobj|-RSB- stimulating|advcl|using stimulating|dobj|secretion secretion|amod|END_ENTITY	-LSB- Various mechanisms of stimulating growth_hormone secretion using growth_hormone_releasing_factor and insulin-induced hypoglycemia -RSB- .
2856651	0	growth_hormone_releasing_factor	6,37	growth_hormone	65,79	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	effects|compound|START_ENTITY END_ENTITY|nsubj|effects	Human growth_hormone_releasing_factor infusion effects on plasma growth_hormone in affective_disorder patients and normal controls .
2858817	0	growth_hormone_releasing_factor	23,54	growth_hormone	58,72	growth hormone releasing factor	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|release release|amod|END_ENTITY	Independent effects of growth_hormone_releasing_factor on growth_hormone release and gene transcription .
2860126	0	growth_hormone_releasing_factor	95,126	growth_hormone	10,24	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Pulsatile growth_hormone secretion in normal man during a continuous 24-hour infusion of human growth_hormone_releasing_factor -LRB- 1-40 -RRB- .
2877535	0	growth_hormone_releasing_factor	42,73	growth_hormone	99,113	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	NH2|compound|START_ENTITY NH2|nmod|secretion secretion|amod|END_ENTITY	The effects of intranasal insufflation of growth_hormone_releasing_factor analogue GRF_1-29 NH2 on growth_hormone secretion in children with short_stature .
2888167	0	growth_hormone_releasing_factor	90,121	growth_hormone	14,28	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	interactions|nmod|START_ENTITY Regulation|dep|interactions Regulation|nmod|secretion secretion|amod|END_ENTITY	Regulation of growth_hormone secretion from human fetal pituitaries : interactions between growth_hormone_releasing_factor and somatostatin .
3082645	0	growth_hormone_releasing_factor	16,47	growth_hormone	89,103	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	dose|nsubj|START_ENTITY dose|nmod|secretion secretion|compound|END_ENTITY	Synthetic human growth_hormone_releasing_factor -LRB- h-GRF-I-44-NH2 -RRB- dose response effect on growth_hormone and prolactin secretion in healthy adult men .
3118426	0	growth_hormone_releasing_factor	12,43	growth_hormone	78,92	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	use|nmod|START_ENTITY -LSB-|dobj|use -LSB-|nmod|test test|nmod|reserve reserve|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The use of growth_hormone_releasing_factor as a test of pituitary reserve of growth_hormone -RSB- .
3125487	0	growth_hormone_releasing_factor	98,129	growth_hormone	26,40	growth hormone releasing factor	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	infusion|nmod|START_ENTITY secretion|nmod|infusion secretion|nsubj|Effect Effect|nmod|testosterone testosterone|nmod|END_ENTITY	Effect of testosterone on growth_hormone secretion in female rats during a continuous infusion of growth_hormone_releasing_factor .
4350846	0	growth_hormone_releasing_factor	22,53	growth_hormone	57,71	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of a purified growth_hormone_releasing_factor on growth_hormone secretion and pituitary cyclic nucleotide content .
6405935	0	growth_hormone_releasing_factor	72,103	growth_hormone	17,31	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Abnormalities Abnormalities|nmod|END_ENTITY	Abnormalities of growth_hormone release in response to human pancreatic growth_hormone_releasing_factor -LRB- GRF _ -LRB- 1-44 -RRB- -RRB- in acromegaly and hypopituitarism .
6423920	0	growth_hormone_releasing_factor	27,58	growth_hormone	76,90	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|secretion secretion|amod|END_ENTITY	Synthetic human pancreatic growth_hormone_releasing_factor -LRB- GRF -RRB- stimulates growth_hormone secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
6424979	0	growth_hormone_releasing_factor	80,111	growth_hormone	36,50	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	glucose|nmod|START_ENTITY glucose|nmod|response response|amod|END_ENTITY	The effect of plasma glucose on the growth_hormone response to human pancreatic growth_hormone_releasing_factor in normal subjects .
6429198	0	growth_hormone_releasing_factor	74,105	growth_hormone	7,21	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	infusions|nmod|START_ENTITY END_ENTITY|nmod|infusions	Plasma growth_hormone responses to constant infusions of human pancreatic growth_hormone_releasing_factor .
6442698	0	growth_hormone_releasing_factor	65,96	growth_hormone	7,21	growth hormone releasing factor	growth hormone	2691	2688	Gene	Gene	administrations|nmod|START_ENTITY END_ENTITY|nmod|administrations	Plasma growth_hormone responses to repetitive administrations of growth_hormone_releasing_factor in patients with pituitary_dwarfism .
1971774	0	growth_hormone_releasing_hormone	4,36	GHRH	38,42	growth hormone releasing hormone	GHRH	2691	2691	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The growth_hormone_releasing_hormone -LRB- GHRH -RRB- response to a mixed meal is blunted in young adults with insulin-dependent_diabetes_mellitus whereas the somatostatin response is normal .
1362733	0	growth_hormone_releasing_hormone	88,120	Growth_hormone	0,14	growth hormone releasing hormone	Growth hormone	2691	2688	Gene	Gene	levels|compound|START_ENTITY induces|nmod|levels induces|nsubj|therapy therapy|amod|END_ENTITY	Growth_hormone therapy in normal short children induces a transitory decrease in plasma growth_hormone_releasing_hormone levels and in human growth_hormone responsiveness to exogenous growth_hormone_releasing_hormone .
2045623	0	growth_hormone_releasing_hormone	34,66	Growth_hormone	0,14	growth hormone releasing hormone	Growth hormone	2691	2688	Gene	Gene	injection|amod|START_ENTITY response|nmod|injection response|amod|END_ENTITY	Growth_hormone response following growth_hormone_releasing_hormone injection in thalassemia major : influence of pubertal development .
3106789	0	growth_hormone_releasing_hormone	54,86	Growth_hormone	1,15	growth hormone releasing hormone	Growth hormone	2691	2688	Gene	Gene	administration|nmod|START_ENTITY secretion|nmod|administration secretion|nsubj|END_ENTITY	-LSB- Growth_hormone secretion following administration of growth_hormone_releasing_hormone in constitutional short_stature and idiopathic growth_hormone deficiency -RSB- .
2516347	0	growth_hormone_releasing_hormone	47,79	Prolactin	1,10	growth hormone releasing hormone	Prolactin	2691	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	-LSB- Prolactin response to acute administration of growth_hormone_releasing_hormone in patients with uremia -RSB- .
12201831	0	growth_hormone_releasing_hormone	120,152	growth_hormone	9,23	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	using|dobj|START_ENTITY sufficient|xcomp|using sufficient|nsubj|determination determination|compound|END_ENTITY	A single growth_hormone -LRB- GH -RRB- determination is sufficient for the diagnosis of GH-deficiency in adult patients using the growth_hormone_releasing_hormone plus growth_hormone releasing peptide-6 test .
1362733	0	growth_hormone_releasing_hormone	184,216	growth_hormone	141,155	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	responsiveness|nmod|START_ENTITY responsiveness|compound|END_ENTITY	Growth_hormone therapy in normal short children induces a transitory decrease in plasma growth_hormone_releasing_hormone levels and in human growth_hormone responsiveness to exogenous growth_hormone_releasing_hormone .
1397474	0	growth_hormone_releasing_hormone	39,71	growth_hormone	82,96	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	action|amod|START_ENTITY action|nmod|END_ENTITY	Role of prostaglandin_E2 -LRB- PGE2 -RRB- in the growth_hormone_releasing_hormone action on growth_hormone , insulin and C-peptide in normal men .
14506689	0	growth_hormone_releasing_hormone	114,146	growth_hormone	36,50	growth hormone releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	caused|nmod|START_ENTITY caused|nsubj|Dynamics Dynamics|nmod|organelles organelles|appos|END_ENTITY	Dynamics of subcellular organelles , growth_hormone , Rab3B , SNAP-25 , and syntaxin in rat pituitary cells caused by growth_hormone_releasing_hormone and somatostatin .
16533151	0	growth_hormone_releasing_hormone	42,74	growth_hormone	133,147	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|dobj|method method|acl|stimulating stimulating|dobj|secretion secretion|compound|END_ENTITY	Plasmid-based expression technology using growth_hormone_releasing_hormone : a novel method for physiologically stimulating long-term growth_hormone secretion .
18341090	0	growth_hormone_releasing_hormone	32,64	growth_hormone	77,91	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|xcomp|evaluate evaluate|dobj|status status|amod|END_ENTITY	Administration of arginine plus growth_hormone_releasing_hormone to evaluate growth_hormone -LRB- GH -RRB- secretory status in children with GH_deficiency .
1908493	0	growth_hormone_releasing_hormone	38,70	growth_hormone	8,22	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	administration|amod|START_ENTITY END_ENTITY|nmod|administration	Altered growth_hormone response after growth_hormone_releasing_hormone administration in chronic_renal_failure .
2004477	0	growth_hormone_releasing_hormone	37,69	growth_hormone	10,24	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Increased growth_hormone response to growth_hormone_releasing_hormone induced by erythropoietin in uraemic patients .
20150954	0	growth_hormone_releasing_hormone	41,73	growth_hormone	14,28	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	The decreased growth_hormone response to growth_hormone_releasing_hormone in obesity is associated to cardiometabolic risk factors .
2045624	0	growth_hormone_releasing_hormone	51,83	growth_hormone	4,18	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	pyridostigmine|dobj|START_ENTITY response|acl|pyridostigmine response|amod|END_ENTITY	The growth_hormone response to pyridostigmine plus growth_hormone_releasing_hormone is not influenced by pubertal maturation .
2108920	0	growth_hormone_releasing_hormone	38,70	growth_hormone	10,24	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Increased growth_hormone responses to growth_hormone_releasing_hormone and thyrotropin_releasing_hormone in patients with metastatic testicular_cancer .
2182500	0	growth_hormone_releasing_hormone	25,57	growth_hormone	108,122	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	injections|nmod|START_ENTITY injections|nmod|volunteers volunteers|nmod|deficiency deficiency|amod|END_ENTITY	Repetitive injections of growth_hormone_releasing_hormone -LRB- GHRH1-44 -RRB- to normal volunteers and patients with growth_hormone deficiency .
2195097	0	growth_hormone_releasing_hormone	31,63	growth_hormone	4,18	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	The growth_hormone response to growth_hormone_releasing_hormone in patients previously treated with bilateral adrenalectomy alone for Cushing 's _ disease .
2266772	0	growth_hormone_releasing_hormone	66,98	growth_hormone	20,34	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Pharmacokinetics Pharmacokinetics|nmod|secretion secretion|amod|END_ENTITY	Pharmacokinetics of growth_hormone secretion in humans induced by growth_hormone_releasing_hormone .
2537727	0	growth_hormone_releasing_hormone	14,46	growth_hormone	85,99	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	therapy|amod|START_ENTITY Comparison|nmod|therapy Comparison|nmod|deficiency deficiency|amod|END_ENTITY	Comparison of growth_hormone_releasing_hormone therapy and growth_hormone therapy in growth_hormone deficiency .
2550207	0	growth_hormone_releasing_hormone	173,205	growth_hormone	155,169	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	response|acl|START_ENTITY response|nmod|END_ENTITY	Growth_hormone_releasing_hormone-sensitive adenylate cyclase activity in growth_hormone-producing pituitary_adenoma : correlation to the response of plasma growth_hormone to growth_hormone_releasing_hormone in patients with acromegaly .
2882405	0	growth_hormone_releasing_hormone	69,101	growth_hormone	115,129	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	Selective beta 1-adrenergic receptor-blockade with atenolol enhances growth_hormone_releasing_hormone and mediated growth_hormone release in man .
2907614	0	growth_hormone_releasing_hormone	71,103	growth_hormone	142,156	growth hormone releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	interacted|nmod|START_ENTITY interacted|xcomp|titrate titrate|dobj|magnitude magnitude|nmod|END_ENTITY	Fractional reduction of somatostatin concentration interacted with rat growth_hormone_releasing_hormone to titrate the magnitude of pulsatile growth_hormone and prolactin release in perifusion .
3098462	0	growth_hormone_releasing_hormone	60,92	growth_hormone	33,47	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	effect|acl|START_ENTITY effect|nmod|oxandrolone oxandrolone|nmod|response response|amod|END_ENTITY	The effect of oxandrolone on the growth_hormone response to growth_hormone_releasing_hormone in children with constitutional growth delay .
3106123	0	growth_hormone_releasing_hormone	10,42	growth_hormone	46,60	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of growth_hormone_releasing_hormone on growth_hormone secretion in type 2 -LRB- non-insulin-dependent -RRB- diabetes mellitus .
3113779	0	growth_hormone_releasing_hormone	23,55	growth_hormone	75,89	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	infusion|nmod|START_ENTITY alter|nsubj|infusion alter|dobj|response response|amod|END_ENTITY	Continuous infusion of growth_hormone_releasing_hormone does not alter the growth_hormone response to different stress stimuli .
3115634	0	growth_hormone_releasing_hormone	42,74	growth_hormone	15,29	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	START_ENTITY|nsubj|response response|amod|END_ENTITY	The higher the growth_hormone response to growth_hormone_releasing_hormone the lower the response to bromocriptine and thyrotrophin releasing hormone in acromegaly .
3133146	0	growth_hormone_releasing_hormone	132,164	growth_hormone	62,76	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	subset|nmod|START_ENTITY subset|dobj|activity activity|nmod|deficiency deficiency|amod|END_ENTITY	Lymphocyte subset distribution and natural killer activity in growth_hormone deficiency before and during short-term treatment with growth_hormone_releasing_hormone .
3143655	0	growth_hormone_releasing_hormone	41,73	growth_hormone	85,99	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	age|nmod|START_ENTITY influence|nmod|age stimulated|nsubj|influence stimulated|dobj|secretion secretion|amod|END_ENTITY	The influence of age on human pancreatic growth_hormone_releasing_hormone stimulated growth_hormone secretion .
3917458	0	growth_hormone_releasing_hormone	59,91	growth_hormone	27,41	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	Effect|acl|START_ENTITY Effect|nmod|response response|amod|dexamethasone dexamethasone|nmod|END_ENTITY	Effect of dexamethasone on growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone in acromegaly .
3927648	0	growth_hormone_releasing_hormone	71,103	growth_hormone	26,40	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	stimulating|nmod|START_ENTITY END_ENTITY|xcomp|stimulating	Evidence of a circulating growth_hormone stimulating factor other than growth_hormone_releasing_hormone in a patient with pituitary_tumour and acromegaly .
7617133	0	growth_hormone_releasing_hormone	114,146	growth_hormone	26,40	growth hormone releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	rats|compound|START_ENTITY challenge|nmod|rats potentiates|nmod|challenge potentiates|dobj|response response|amod|END_ENTITY	Clonidine potentiates the growth_hormone response to a growth_hormone_releasing_hormone challenge in hypothalamic growth_hormone_releasing_hormone deficient rats .
7617133	0	growth_hormone_releasing_hormone	55,87	growth_hormone	26,40	growth hormone releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	challenge|amod|START_ENTITY potentiates|nmod|challenge potentiates|dobj|response response|amod|END_ENTITY	Clonidine potentiates the growth_hormone response to a growth_hormone_releasing_hormone challenge in hypothalamic growth_hormone_releasing_hormone deficient rats .
7681861	0	growth_hormone_releasing_hormone	85,117	growth_hormone	48,62	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	stimuli|compound|START_ENTITY restores|nmod|stimuli restores|dobj|responses responses|compound|END_ENTITY	Galanin infusion partially restores the blunted growth_hormone responses to repeated growth_hormone_releasing_hormone stimuli in normal adults .
7780546	0	growth_hormone_releasing_hormone	47,79	growth_hormone	14,28	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	Treatment|nmod|START_ENTITY Treatment|nmod|deficiencies deficiencies|amod|END_ENTITY	-LSB- Treatment of growth_hormone deficiencies with growth_hormone_releasing_hormone .
7976413	0	growth_hormone_releasing_hormone	54,86	growth_hormone	27,41	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Lowering cortisol enhances growth_hormone response to growth_hormone_releasing_hormone in healthy subjects .
8006330	0	growth_hormone_releasing_hormone	113,145	growth_hormone	86,100	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	enhance|advcl|START_ENTITY enhance|dobj|response response|amod|END_ENTITY	Low doses of either intravenously or orally administered arginine are able to enhance growth_hormone response to growth_hormone_releasing_hormone in elderly subjects .
8241653	0	growth_hormone_releasing_hormone	72,104	growth_hormone	45,59	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Oral administration of arginine enhances the growth_hormone response to growth_hormone_releasing_hormone in short children .
8445152	0	growth_hormone_releasing_hormone	56,88	growth_hormone	111,125	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	NH2-stimulated|amod|START_ENTITY suppress|iobj|NH2-stimulated suppress|dobj|secretion secretion|amod|END_ENTITY	Physiological levels of growth_hormone fail to suppress growth_hormone_releasing_hormone -LRB- 1-29 -RRB- NH2-stimulated growth_hormone secretion in man .
8445152	0	growth_hormone_releasing_hormone	56,88	growth_hormone	24,38	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	NH2-stimulated|amod|START_ENTITY suppress|iobj|NH2-stimulated fail|xcomp|suppress fail|nsubj|levels levels|nmod|END_ENTITY	Physiological levels of growth_hormone fail to suppress growth_hormone_releasing_hormone -LRB- 1-29 -RRB- NH2-stimulated growth_hormone secretion in man .
8513607	0	growth_hormone_releasing_hormone	95,127	growth_hormone	63,77	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	stimulation|amod|START_ENTITY response|nmod|stimulation response|amod|END_ENTITY	Recombinant human erythropoietin -LRB- rhEPO -RRB- treatment potentiates growth_hormone -LRB- GH -RRB- response to growth_hormone_releasing_hormone -LRB- GHRH -RRB- stimulation in hemodialysis patients .
8588384	0	growth_hormone_releasing_hormone	11,43	growth_hormone	91,105	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	Action|nmod|START_ENTITY EEG|nsubj|Action EEG|dobj|secretion secretion|nmod|END_ENTITY	-LSB- Action of growth_hormone_releasing_hormone -LRB- GHRH -RRB- on sleep EEG and nocturnal secretion of growth_hormone , cortisol and ACTH in patients with major_depression -RSB- .
8740245	0	growth_hormone_releasing_hormone	10,42	growth_hormone	46,60	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of growth_hormone_releasing_hormone on growth_hormone , prostaglandin_E2 and insulin in non-insulin-dependent diabetic patients .
8851324	0	growth_hormone_releasing_hormone	51,83	growth_hormone	13,27	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	stimulation|nmod|START_ENTITY END_ENTITY|nmod|stimulation	-LSB- Behavior of growth_hormone after stimulation with growth_hormone_releasing_hormone -LRB- GHRH -RRB- in children with disorders_of_the_hypothalamo-hypophyseal_axis and girls with Turner_syndrome -RSB- .
9007701	0	growth_hormone_releasing_hormone	47,79	growth_hormone	14,28	growth hormone releasing hormone	growth hormone	2691	2688	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|Impairment Impairment|nmod|END_ENTITY	Impairment of growth_hormone responsiveness to growth_hormone_releasing_hormone and pyridostigmine in patients affected by Prader-Labhardt-Willi_syndrome .
9176843	0	growth_hormone_releasing_hormone	110,142	growth_hormone	80,94	growth hormone releasing hormone	growth hormone	29446(Tax:10116)	81668(Tax:10116)	Gene	Gene	secrete|advcl|START_ENTITY secrete|dobj|END_ENTITY	Severe uremia depresses the ability of perifused rat pituitary cells to secrete growth_hormone in response to growth_hormone_releasing_hormone .
1519429	0	growth_hormone_releasing_hormone	11,43	insulin	47,54	growth hormone releasing hormone	insulin	2691	3630	Gene	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Effects of growth_hormone_releasing_hormone on insulin action and insulin secretion in a hypopituitary patient evaluated by the clamp technique .
15336233	0	growth_hormone_releasing_hormone_receptor	30,71	GHRHR	73,78	growth hormone releasing hormone receptor	GHRHR	2692	2692	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A nonsense mutation -LRB- E72X -RRB- in growth_hormone_releasing_hormone_receptor -LRB- GHRHR -RRB- gene is the major cause of familial isolated growth_hormone_deficiency in Western region of India : founder effect suggested by analysis of dinucleotide repeat polymorphism close to GHRHR gene .
20354904	0	growth_hormone_releasing_hormone_receptor	49,90	GHRHR	92,97	growth hormone releasing hormone receptor	GHRHR	102184221	102184221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of genetic variability of the dairy goat growth_hormone_releasing_hormone_receptor -LRB- GHRHR -RRB- gene on growth traits .
9348177	0	growth_hormone_secretagogue-receptor	13,49	GHS-R	51,56	growth hormone secretagogue-receptor	GHS-R	84022(Tax:10116)	84022(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Hypothalamic growth_hormone_secretagogue-receptor -LRB- GHS-R -RRB- expression is regulated by growth hormone in the rat .
15380232	0	growth_hormone_secretagogue_receptor	32,68	GHS-R	70,75	growth hormone secretagogue receptor	GHS-R	2693	2693	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Novel isoxazole_carboxamides as growth_hormone_secretagogue_receptor -LRB- GHS-R -RRB- antagonists .
20658315	0	growth_hormone_secretagogue_receptor	26,62	GHSR	64,68	growth hormone secretagogue receptor	GHSR	102173610	102173610	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel SNPs of the caprine growth_hormone_secretagogue_receptor -LRB- GHSR -RRB- gene and their association with growth traits in goats .
22735618	0	growth_hormone_secretagogue_receptor	16,52	GHSR	54,58	growth hormone secretagogue receptor	GHSR	443238(Tax:9940)	443238(Tax:9940)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Associations of growth_hormone_secretagogue_receptor -LRB- GHSR -RRB- genes polymorphisms and protein structure changes with carcass traits in sheep .
15616037	0	growth_hormone_secretagogue_receptor	39,75	ghrelin_receptor	77,93	growth hormone secretagogue receptor	ghrelin receptor	2693	2693	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic linkage and association of the growth_hormone_secretagogue_receptor -LRB- ghrelin_receptor -RRB- gene in human obesity .
7655350	0	growth_inhibitory_factor	14,38	GIF	40,43	growth inhibitory factor	GIF	117038(Tax:10116)	117038(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of growth_inhibitory_factor -LRB- GIF -RRB- in normal and injured rat brains .
10537052	0	growth_inhibitory_factor	14,38	epidermal_growth_factor	53,76	growth inhibitory factor	epidermal growth factor	117038(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of growth_inhibitory_factor expression by epidermal_growth_factor and interleukin-1beta in cultured rat astrocytes .
10218634	0	growth_inhibitory_factor	14,38	metallothionein-III	40,59	growth inhibitory factor	metallothionein-III	4504	4504	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of growth_inhibitory_factor -LRB- metallothionein-III -RRB- mRNA and protein following excitotoxic immature brain_injury .
8863896	0	grp78	49,54	glucose-regulated_protein	22,47	grp78	glucose-regulated protein	25617(Tax:10116)	25617(Tax:10116)	Gene	Gene	Changes|appos|START_ENTITY Changes|nmod|END_ENTITY	Changes of the 78 kDa glucose-regulated_protein -LRB- grp78 -RRB- in livers of diabetic rats .
10647820	0	grx	46,49	glutaredoxin	32,44	grx	glutaredoxin	93692(Tax:10090)	93692(Tax:10090)	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Cloning and sequencing of mouse glutaredoxin -LRB- grx -RRB- cDNA .
1363402	0	gsI	41,44	glutamine_synthetase_I	17,39	gsI	glutamine synthetase I	33172(Tax:7227)	33172(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutations in the glutamine_synthetase_I -LRB- gsI -RRB- gene produce embryo-lethal female sterility in Drosophila_melanogaster .
17576137	0	gsnl1	93,98	gelsolin-like_1	76,91	gsnl1	gelsolin-like 1	323285(Tax:7955)	323285(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transgenic analysis of the anterior eye-specific enhancers of the zebrafish gelsolin-like_1 -LRB- gsnl1 -RRB- gene .
18070145	0	gsp	196,199	G-protein_alpha_subunit	171,194	gsp	G-protein alpha subunit	2778	2778	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Expression of pituitary_tumour-derived , N-terminally truncated isoform of fibroblast_growth_factor_receptor_4 -LRB- ptd-FGFR4 -RRB- correlates with tumour invasiveness but not with G-protein_alpha_subunit -LRB- gsp -RRB- mutation in human GH-secreting pituitary_adenomas .
10773456	0	gst-3	88,93	GST	77,80	gst-3	GST	37106(Tax:7227)	36927(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a new theta-class glutathione-S-transferase -LRB- GST -RRB- gene , gst-3 , from Drosophila_melanogaster .
10773456	0	gst-3	88,93	glutathione-S-transferase	50,75	gst-3	glutathione-S-transferase	37106(Tax:7227)	36927(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a new theta-class glutathione-S-transferase -LRB- GST -RRB- gene , gst-3 , from Drosophila_melanogaster .
16158240	0	gtr	30,33	glutamyl-trna_reductase	85,108	gtr	glutamyl-trna reductase	5717992(Tax:3055)	5717992(Tax:3055)	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	The Chlamydomonas_reinhardtii gtr gene encoding the tetrapyrrole biosynthetic enzyme glutamyl-trna_reductase : structure of the gene and properties of the expressed enzyme .
16293431	0	guanidinoacetate_methyltransferase	24,58	GAMT	60,64	guanidinoacetate methyltransferase	GAMT	2593	2593	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A mutation on exon 6 of guanidinoacetate_methyltransferase -LRB- GAMT -RRB- gene supports a different function for isoform a and b of GAMT enzyme .
18593884	0	guanine-rich_sequence-binding_factor_1	72,110	glutathione_peroxidase_4	28,52	guanine-rich sequence-binding factor 1	glutathione peroxidase 4	231413(Tax:10090)	625249(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Translational regulation of glutathione_peroxidase_4 expression through guanine-rich_sequence-binding_factor_1 is essential for embryonic brain development .
2858814	0	guanylate	62,71	gonadotropin_releasing_hormone	17,47	C.4.6.1.2	gonadotropin releasing hormone	1040044(Tax:199310)	2796	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Cation-dependent gonadotropin_releasing_hormone activation of guanylate cyclase .
23405236	0	guanylate-binding_protein_1	66,93	Nonstructural_protein_1	0,23	guanylate-binding protein 1	Nonstructural protein 1	2633	10625	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nonstructural_protein_1 of influenza_A_virus interacts with human guanylate-binding_protein_1 to antagonize antiviral activity .
10230502	0	guanylate-binding_protein_3	53,80	mGBP3	82,87	guanylate-binding protein 3	mGBP3	55932(Tax:10090)	55932(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interferon-gamma and lipopolysaccharide induce mouse guanylate-binding_protein_3 -LRB- mGBP3 -RRB- expression in the murine macrophage cell line RAW264 .7 .
15953638	0	guanylate_cyclase-activating_protein_1	38,76	GUCA1A	21,27	guanylate cyclase-activating protein 1	GUCA1A	2980	2978	Gene	Gene	Mutation|amod|START_ENTITY Mutation|nmod|END_ENTITY	Mutation in the gene GUCA1A , encoding guanylate_cyclase-activating_protein_1 , causes cone , cone-rod , and macular_dystrophy .
10507726	0	guanylate_cyclase_activator_1B	24,54	GUCA1B	56,62	guanylate cyclase activator 1B	GUCA1B	2979	2979	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic analysis of the guanylate_cyclase_activator_1B -LRB- GUCA1B -RRB- gene in patients with autosomal_dominant_retinal_dystrophies .
18037771	0	guanylate_cyclase_activator_2B	66,96	GUCA2B	98,104	guanylate cyclase activator 2B	GUCA2B	2981	2981	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotype-based case-control study of the association between the guanylate_cyclase_activator_2B -LRB- GUCA2B , Uroguanylin -RRB- gene and essential hypertension .
10844022	0	guanylate_kinase_domain-associated_protein	43,85	postsynaptic_density-95	19,42	guanylate kinase domain-associated protein	postsynaptic density-95	65040(Tax:10116)	116681(Tax:10116)	Gene	Gene	complex|amod|START_ENTITY Interaction|dep|complex Interaction|nmod|END_ENTITY	Interaction of the postsynaptic_density-95 / guanylate_kinase_domain-associated_protein complex with a light chain of myosin-V and dynein .
9632692	0	guanylyl_cyclase-A	96,114	atrial_natriuretic_peptide	59,85	guanylyl cyclase-A	atrial natriuretic peptide	18160(Tax:10090)	230899(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Dual role for adenine_nucleotides in the regulation of the atrial_natriuretic_peptide receptor , guanylyl_cyclase-A .
11579116	0	guanylyl_cyclase_C	22,40	CD34	44,48	guanylyl cyclase C	CD34	2984	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Ectopic expression of guanylyl_cyclase_C in CD34 + progenitor cells in peripheral blood .
21305056	0	guanylyl_cyclase_C	8,26	GCC	28,31	guanylyl cyclase C	GCC	14917(Tax:10090)	14917(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Loss of guanylyl_cyclase_C -LRB- GCC -RRB- signaling leads to dysfunctional intestinal barrier .
18541533	0	guanylyl_cyclase_activating_protein_1	11,48	GCAP1	50,55	guanylyl cyclase activating protein 1	GCAP1	2978	2978	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of guanylyl_cyclase_activating_protein_1 -LRB- GCAP1 -RRB- to retinal_guanylyl cyclase -LRB- RetGC1 -RRB- .
21901559	0	guanylyl_cyclase_c	17,35	GCC	37,40	guanylyl cyclase c	GCC	2984	2984	Gene	Gene	expressions|compound|START_ENTITY expressions|appos|END_ENTITY	Peripheral blood guanylyl_cyclase_c -LRB- GCC -RRB- expressions are associated with prognostic parameters and response to therapy in colorectal_cancer patients .
23321552	0	gulo	61,65	SVCT2	71,76	gulo	SVCT2	268756(Tax:10090)	54338(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Combined vitamin_C and E deficiency induces motor_defects in gulo -LRB- - / - -RRB- / SVCT2 -LRB- + / - -RRB- mice .
12591598	0	gurken	16,22	Bruno	0,5	gurken	Bruno	34171(Tax:7227)	34648(Tax:7227)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Bruno regulates gurken during Drosophila oogenesis .
25447475	0	gustin	4,10	CA6	12,15	gustin	CA6	765	765	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The gustin -LRB- CA6 -RRB- gene polymorphism , rs2274333 -LRB- A/G -RRB- , is associated with fungiform_papilla density , whereas PROP bitterness is mostly due to TAS2R38 in an ethnically-mixed population .
9621516	0	hABC7	65,70	ABC_transporter	43,58	hABC7	ABC transporter	22	9429	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Cloning and chromosomal mapping of a novel ABC_transporter gene -LRB- hABC7 -RRB- , a candidate for X-linked_sideroblastic_anemia with spinocerebellar_ataxia .
18059173	0	hADA2a	0,6	beta-catenin	101,113	hADA2a	beta-catenin	6871	1499	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	hADA2a and hADA3 are required for acetylation , transcriptional activity and proliferative effects of beta-catenin .
9790916	0	hAG-2	0,5	XAG-2	67,72	hAG-2	XAG-2	10551	379354(Tax:8355)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	hAG-2 , the human homologue of the Xenopus_laevis cement gland gene XAG-2 , is coexpressed with estrogen receptor in breast_cancer cell lines .
10975464	0	hAOX1	42,47	aldehyde_oxidase	24,40	hAOX1	aldehyde oxidase	316	51	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Activation of the human aldehyde_oxidase -LRB- hAOX1 -RRB- promoter by tandem cooperative Sp1/Sp3 binding sites : identification of complex architecture in the hAOX upstream DNA that includes a proximal promoter , distal activation sites , and a silencer element .
16033069	0	hAR	42,45	androgen_receptor	23,40	hAR	androgen receptor	10894	367	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphisms of human androgen_receptor -LRB- hAR -RRB- gene in prostate_cancer cell lines PC-EW and PC-OR .
11129342	0	hARNT	70,75	Ah_receptor_nuclear_translocator	31,63	hARNT	Ah receptor nuclear translocator	405	405	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Genomic structure of the human Ah_receptor_nuclear_translocator gene -LRB- hARNT -RRB- .
17452980	0	hAda3	0,5	p53	31,34	hAda3	p53	10474	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	hAda3 regulates p14ARF-induced p53 acetylation and senescence .
12714616	0	hBD-2	96,101	IL-1beta	72,80	hBD-2	IL-1beta	1673	3553	Gene	Gene	expression|amod|START_ENTITY stimulation|nmod|expression stimulation|compound|END_ENTITY	Defensin expression by the cornea : multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells .
15627069	0	hBD-3	23,28	beta-defensin_3	6,21	hBD-3	beta-defensin 3	55894	55894	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Human beta-defensin_3 -LRB- hBD-3 -RRB- expression in A431 cell line and human vulval_tumors .
18492183	0	hBD2	94,98	beta-defensin_2_or_3	72,92	hBD2	beta-defensin 2 or 3	1673	1673;55894	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	An optimized method for intensive screening of molecules that stimulate beta-defensin_2_or_3 -LRB- hBD2 or hBD3 -RRB- expression in cultured normal human keratinocytes .
27034006	0	hBD3	72,76	p53	122,125	hBD3	p53	55894	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Human_papillomavirus oncogenic E6 protein regulates human b-defensin 3 -LRB- hBD3 -RRB- expression via the tumor suppressor protein p53 .
10749118	0	hBUBR1	73,79	BRCA2	18,23	hBUBR1	BRCA2	701	675	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1 .
23360090	0	hCA-II	44,50	carbonic_anhydrase-II	21,42	hCA-II	carbonic anhydrase-II	760	760	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	An interactive human carbonic_anhydrase-II -LRB- hCA-II -RRB- receptor -- pharmacophore molecular model _ anti-convulsant activity of the designed and synthesized 5-amino-1 ,3,4 - thiadiazole-2-thiol conjugated imine derivatives .
15644269	0	hCAD	115,119	TP53	75,79	hCAD	TP53	730249	7157	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Modulation of age at_onset of Huntington_disease patients by variations in TP53 and human caspase_activated_DNase -LRB- hCAD -RRB- genes .
15644269	0	hCAD	115,119	caspase_activated_DNase	90,113	hCAD	caspase activated DNase	730249	1677	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Modulation of age at_onset of Huntington_disease patients by variations in TP53 and human caspase_activated_DNase -LRB- hCAD -RRB- genes .
12860015	0	hCAP-18	20,27	LL-37	14,19	hCAP-18	LL-37	820	820	Gene	Gene	gene|amod|START_ENTITY Expression|dep|gene Expression|nmod|END_ENTITY	Expression of LL-37 / hCAP-18 gene in human leukemia cells .
15364108	0	hCAP-18	65,72	LL-37	73,78	hCAP-18	LL-37	820	820	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Bacterial products increase expression of the human cathelicidin hCAP-18 / LL-37 in cultured human sinus epithelial cells .
20646232	0	hCAP-18	22,29	LL-37	30,35	hCAP-18	LL-37	820	820	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Antimicrobial peptide hCAP-18 / LL-37 protein and mRNA expressions in different_periodontal_diseases .
26433491	0	hCAP-18	74,81	LL-37	82,87	hCAP-18	LL-37	820	820	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Vitamin_D3 modulates the innate immune response through regulation of the hCAP-18 / LL-37 gene expression and cytokine production .
17437146	0	hCASK	71,76	hCD98	34,39	hCASK	hCD98	8573	6520	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Extracellular interaction between hCD98 and the PDZ class II domain of hCASK in intestinal epithelia .
12381680	0	hCCR1	137,142	MIP-1beta	157,166	hCCR1	MIP-1beta	1230	6351	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Pharmacological characterization of the chemokine_receptor , hCCR1 in a stable transfectant and differentiated HL-60 cells : antagonism of hCCR1 activation by MIP-1beta .
12381680	0	hCCR1	60,65	MIP-1beta	157,166	hCCR1	MIP-1beta	1230	6351	Gene	Gene	chemokine_receptor|appos|START_ENTITY characterization|nmod|chemokine_receptor characterization|dep|antagonism antagonism|nmod|activation activation|nmod|END_ENTITY	Pharmacological characterization of the chemokine_receptor , hCCR1 in a stable transfectant and differentiated HL-60 cells : antagonism of hCCR1 activation by MIP-1beta .
17437146	0	hCD98	34,39	hCASK	71,76	hCD98	hCASK	6520	8573	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Extracellular interaction between hCD98 and the PDZ class II domain of hCASK in intestinal epithelia .
10649446	0	hCDC47	104,110	FHL2	31,35	hCDC47	FHL2	4176	2274	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Protein-protein interaction of FHL2 , a LIM domain protein preferentially expressed in human heart , with hCDC47 .
3604700	0	hCG	16,19	ABP	85,88	hCG	ABP	3342	24775(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Acute effect of hCG on testicular and epididymal levels of androgen_binding_protein -LRB- ABP -RRB- in the immature rat .
9556039	0	hCG	61,64	AFP	43,46	hCG	AFP	93659	174	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|dobj|levels	The influence of smoking on maternal serum AFP and free beta hCG levels and the impact on screening for Down syndrome .
21832169	0	hCG	135,138	CGB6	125,129	hCG	CGB6	93659	94027	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Expression and production of human chorionic_gonadotropin _ -LRB- hCG -RRB- in the normal secretory endometrium : evidence of CGB7 and/or CGB6 beta hCG subunit gene expression .
21832169	0	hCG	135,138	CGB7	113,117	hCG	CGB7	93659	94027	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Expression and production of human chorionic_gonadotropin _ -LRB- hCG -RRB- in the normal secretory endometrium : evidence of CGB7 and/or CGB6 beta hCG subunit gene expression .
16257052	0	hCG	145,148	IL-1beta	112,120	hCG	IL-1beta	93659	3553	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	hCG Secretion in human choriocarcinoma JAR cells is MAPK but not Stat3 dependent : contributions of TNFalpha and IL-1beta to inflammation-induced hCG secretion .
9334854	0	hCG	11,14	IL-2	31,35	hCG	IL-2	93659	3558	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|amod|END_ENTITY	Effects of hCG and beta-hCG on IL-2 and sIL-2R secretion from human peripheral blood mononuclear cells : a dose-response study in vitro .
12771231	0	hCG	129,132	Melanoma_cell_adhesion_molecule	0,31	hCG	Melanoma cell adhesion molecule	1081	4162	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Melanoma_cell_adhesion_molecule -LRB- MCAM/CD146 -RRB- is expressed on human luteinizing granulosa cells : enhancement of its expression by hCG , interleukin-1_and_tumour_necrosis_factor-alpha .
17962101	0	hCG	6,9	alpha-fetoprotein	45,62	hCG	alpha-fetoprotein	93659	174	Gene	Gene	combined|nsubj|START_ENTITY combined|nmod|END_ENTITY	Total hCG versus free beta-hCG combined with alpha-fetoprotein for Down syndrome screening in Taiwan .
7531327	0	hCG	51,54	alpha-fetoprotein	24,41	hCG	alpha-fetoprotein	93659	174	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	The association between alpha-fetoprotein and beta hCG levels prior to and following chorionic_villus_sampling in cases that spontaneously miscarried .
17520403	0	hCG	59,62	amphiregulin	14,26	hCG	amphiregulin	3342	374	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of amphiregulin , EGFR-like factor expression by hCG in cultured human granulosa cells .
3604700	0	hCG	16,19	androgen_binding_protein	59,83	hCG	androgen binding protein	3342	24775(Tax:10116)	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Acute effect of hCG on testicular and epididymal levels of androgen_binding_protein -LRB- ABP -RRB- in the immature rat .
20213583	0	hCG	41,44	angiopoietin-2	18,32	hCG	angiopoietin-2	3342	285	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of the angiopoietin-2 gene by hCG in ovarian_cancer cell line OVCAR-3 .
187505	0	hCG	54,57	hCG	71,74	hCG	hCG	3342	3342	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Ontogenesis , distribution and relative sensitivity of hCG receptors to hCG and LH in goat ovaries .
187505	0	hCG	71,74	hCG	54,57	hCG	hCG	3342	3342	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Ontogenesis , distribution and relative sensitivity of hCG receptors to hCG and LH in goat ovaries .
12942243	0	hCG	15,18	hPL	37,40	hCG	hPL	93659	3956	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of hCG and inhibition of hPL in isolated human trophoblast cells in vitro by glycodelin_A .
21477953	0	hCG	108,111	vascular_endothelial_growth_factor	70,104	hCG	vascular endothelial growth factor	93659	281572(Tax:9913)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Activation of PI3K/mTOR signaling pathway contributes to induction of vascular_endothelial_growth_factor by hCG in bovine developing luteal cells .
17086422	0	hCGbeta	109,116	C3d	48,51	hCGbeta	C3d	1082	100861467	Gene	Gene	responses|nmod|START_ENTITY END_ENTITY|nmod|responses	The distinct effects of three tandem repeats of C3d in the immune responses against tumor-associated antigen hCGbeta by DNA immunization .
19041851	0	hCMEC/D3	86,94	P450	78,82	hCMEC/D3	P450	1735	1555	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells .
3501746	0	hCRF	44,48	pancreatic_polypeptide	9,31	hCRF	pancreatic polypeptide	1392	5539	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Impaired pancreatic_polypeptide response to hCRF in type 2 diabetics : restoration to normal by an opioid antagonist .
21453774	0	hCTRP2	129,135	C1q_and_tumor_necrosis_factor_related_protein_2	80,127	hCTRP2	C1q and tumor necrosis factor related protein 2	114898	114898	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	High level expression , purification and characterization of active fusion human C1q_and_tumor_necrosis_factor_related_protein_2 -LRB- hCTRP2 -RRB- in Escherichia_coli .
16762476	0	hCYP1A2	69,76	cytochrome_P-450_1A2	47,67	hCYP1A2	cytochrome P-450 1A2	1544	1544	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Apiaceous vegetable constituents inhibit human cytochrome_P-450_1A2 -LRB- hCYP1A2 -RRB- activity and hCYP1A2-mediated mutagenicity of aflatoxin_B1 .
12006993	0	hCacyBP	60,67	calcyclin_binding_protein	33,58	hCacyBP	calcyclin binding protein	27101	27101	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Cloning and expression of human calcyclin_binding_protein -LRB- hCacyBP -RRB- gene -RSB- .
26660891	0	hCutC	30,35	CutC	19,23	hCutC	CutC	51076	51076	Gene	Gene	Gene|dep|START_ENTITY Gene|compound|END_ENTITY	Silencing of Human CutC Gene -LRB- hCutC -RRB- Induces Apoptosis in HepG2 Cells .
18258190	0	hCyP33	81,87	PPIase	62,68	hCyP33	PPIase	10450	23759	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Human CyP33 binds specifically to mRNA and binding stimulates PPIase activity of hCyP33 .
9067310	0	hD2	91,94	D3	87,89	hD2	D3	28503	1735	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Interactions of -LRB- + -RRB- - _ and _ -LRB- - -RRB- -8 - _ and_7-hydroxy-2 - -LRB- di-n-propylamino -RRB- tetralin at human -LRB- h -RRB- D3 , hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats .
10918393	0	hD52	4,8	TPD52	10,15	hD52	TPD52	7163	7163	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The hD52 -LRB- TPD52 -RRB- gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast_carcinoma .
22916232	0	hDM2	72,76	p53	44,47	hDM2	p53	28508	7157	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable .
19415930	0	hDMX	74,78	p53	53,56	hDMX	p53	4193	7157	Gene	Gene	START_ENTITY|nmod|Improvement Improvement|nmod|inhibitors inhibitors|nmod|hDM2 hDM2|nummod|END_ENTITY	In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX .
11687976	0	hDab-2	6,12	ILK	22,25	hDab-2	ILK	1601	3611	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	DOC-2 / hDab-2 inhibits ILK activity and induces anoikis in breast_cancer cells through an Akt-independent pathway .
22185284	0	hDlg	34,38	E-cadherin	55,65	hDlg	E-cadherin	1739	999	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring .
20605917	0	hDlg	81,85	PSF	42,45	hDlg	PSF	1739	6421	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|interaction interaction|nmod|END_ENTITY	p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock .
20605917	0	hDlg	81,85	p38gamma	0,8	hDlg	p38gamma	1739	6300	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock .
17332497	0	hDlg1	53,58	MPP7	18,22	hDlg1	MPP7	1739	143098	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation .
20523736	0	hEAG1	28,33	Calmodulin	0,10	hEAG1	Calmodulin	3756	808	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Calmodulin interaction with hEAG1 visualized by FRET microscopy .
2595297	0	hEGF	11,15	MG111	17,22	hEGF	MG111	1950	875452(Tax:243273)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of hEGF -LRB- MG111 -RRB- on gastric mucosal potential difference in rats .
1621612	0	hEGF	44,48	basic_fibroblast_growth_factor	51,81	hEGF	basic fibroblast growth factor	1950	2247	Gene	Gene	factor|appos|START_ENTITY factor|appos|END_ENTITY	-LSB- Presence of human epidermal growth factor -LRB- hEGF -RRB- , basic_fibroblast_growth_factor -LRB- bFGF -RRB- in human aqueous -RSB- .
2206955	0	hEGF	33,37	epidermal_growth_factor	8,31	hEGF	epidermal growth factor	1950	1950	Gene	Gene	levels|appos|START_ENTITY END_ENTITY|dobj|levels	Urinary epidermal_growth_factor -LRB- hEGF -RRB- levels in patients with carcinomas of the breast , colon and rectum .
2233130	0	hEGF	41,45	epidermal_growth_factor	16,39	hEGF	epidermal growth factor	1950	1950	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of human epidermal_growth_factor -LRB- hEGF -RRB- on splanchnic circulation in dogs .
26722215	0	hELG1	40,45	ATAD5	47,52	hELG1	ATAD5	79915	79915	Gene	Gene	START_ENTITY|dep|Expression Expression|compound|END_ENTITY	Hepatitis_B_Virus X Protein Upregulates hELG1 / ATAD5 Expression through E2F1 in Hepatocellular_Carcinoma .
26722215	0	hELG1	40,45	E2F1	72,76	hELG1	E2F1	79915	1869	Gene	Gene	START_ENTITY|dep|Expression Expression|nmod|END_ENTITY	Hepatitis_B_Virus X Protein Upregulates hELG1 / ATAD5 Expression through E2F1 in Hepatocellular_Carcinoma .
11770002	0	hEMT	57,61	extraneuronal_monoamine_transporter	20,55	hEMT	extraneuronal monoamine transporter	3702	6581	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human extraneuronal_monoamine_transporter -LRB- hEMT -RRB- expressed in HEK293 cells by intracellular second messenger systems .
22349506	0	hENT1	52,57	PPARa	0,5	hENT1	PPARa	2030	5465	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	PPARa and PPARy regulate the nucleoside transporter hENT1 .
26031529	0	hENT1	21,26	SKM-1	30,35	hENT1	SKM-1	2030	6329	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- Functional study of hENT1 on SKM-1 cell resistance to decitabine -RSB- .
19193655	0	hENT1	46,51	TGF-beta1	0,9	hENT1	TGF-beta1	2030	7040	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TGF-beta1 inhibits expression and activity of hENT1 in a nitric_oxide-dependent manner in human umbilical vein endothelium .
21678404	0	hENT1	62,67	equilibrative_nucleoside_transporter_1	22,60	hENT1	equilibrative nucleoside transporter 1	2030	2030	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	New role of the human equilibrative_nucleoside_transporter_1 -LRB- hENT1 -RRB- in epithelial-to-mesenchymal transition in renal tubular cells .
19106487	0	hEPO	66,70	erythropoietin	50,64	hEPO	erythropoietin	2056	2056	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Production of transgenic pigs harboring the human erythropoietin -LRB- hEPO -RRB- gene using somatic cell nuclear transfer .
22173492	0	hERG	36,40	LQT2	53,57	hERG	LQT2	2078	3757	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Electrophysiological study of V535M hERG mutation of LQT2 .
22879586	0	hERG	61,65	Nedd4-2	136,143	hERG	Nedd4-2	2078	23327	Gene	Gene	channels|compound|START_ENTITY expression|nmod|channels regulated|nsubjpass|expression regulated|nmod|protein protein|nmod|END_ENTITY	Cell surface expression of human ether-a-go-go-related gene -LRB- hERG -RRB- channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2 .
23589291	0	hERG	71,75	Nedd4-2	116,123	hERG	Nedd4-2	2078	23327	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|END_ENTITY	The serum - _ and_glucocorticoid-inducible_kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11 .
23792956	0	hERG	52,56	Nedd4-2	166,173	hERG	Nedd4-2	2078	23327	Gene	Gene	Regulation|dep|START_ENTITY channel|nsubj|Regulation channel|nmod|neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2 neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2|appos|END_ENTITY	Regulation of the human ether-a-go-go-related gene -LRB- hERG -RRB- channel by Rab4 protein through neural_precursor_cell-expressed_developmentally_down-regulated_protein_4-2 -LRB- Nedd4-2 -RRB- .
24688054	0	hERG	41,45	Nedd4-2	109,116	hERG	Nedd4-2	2078	23327	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2 .
12011094	0	hER_alpha	82,91	estrogen_receptor-alpha	57,80	hER alpha	estrogen receptor-alpha	26284	2099	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Natural trans-spliced mRNAs are generated from the human estrogen_receptor-alpha -LRB- hER_alpha -RRB- gene .
16809764	0	hEST1B	70,76	ever-shorter_telomeres_1B	43,68	hEST1B	ever-shorter telomeres 1B	23381	23381	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Histone_deacetylase_8 safeguards the human ever-shorter_telomeres_1B -LRB- hEST1B -RRB- protein from ubiquitin-mediated degradation .
9288757	0	hEST2	0,5	telomerase_catalytic_subunit	26,54	hEST2	telomerase catalytic subunit	7015	7015	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	hEST2 , the putative human telomerase_catalytic_subunit gene , is up-regulated in tumor cells and during immortalization .
16581652	0	hFAT	47,51	FAT1	41,45	hFAT	FAT1	2195	2195	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Immunohistological localisation of human FAT1 -LRB- hFAT -RRB- protein in 326 breast_cancers .
24667174	0	hFBH1	66,71	SCF	62,65	hFBH1	SCF	84893	4254	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of two E2 ubiquitin conjugating enzymes in SCF -LRB- hFBH1 -RRB- catalyzed polyubiquitination .
12182072	0	hFIX	30,34	FIX	26,29	hFIX	FIX	2158	2158	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	-LSB- High expression of human FIX -LRB- hFIX -RRB- in transgenic_mice directed by goat beta-casein gene promoter -RSB- .
10438528	0	hFOG-2	0,6	mCtBP2	60,66	hFOG-2	mCtBP2	23414	13017(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	hFOG-2 , a novel zinc finger protein , binds the co-repressor mCtBP2 and modulates GATA-mediated activation .
17920884	0	hFPRL1	49,55	ALXR	60,64	hFPRL1	ALXR	2358	2358	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	New ` chemical probes ' to examine the role of the hFPRL1 -LRB- or ALXR -RRB- receptor in inflammation .
7680917	0	hFc_gamma_RI	46,58	Granulocyte_colony-stimulating_factor	0,37	hFc gamma RI	Granulocyte colony-stimulating factor	2209	1440	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor induces hFc_gamma_RI -LRB- CD64 antigen -RRB- - positive neutrophils via an effect on myeloid precursor cells .
18066430	0	hG-CSF	95,101	Granulocyte_Colony_Stimulating_Factor	56,93	hG-CSF	Granulocyte Colony Stimulating Factor	1440	1440	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Production of transgenic goat -LRB- Capra_hircus -RRB- with human Granulocyte_Colony_Stimulating_Factor -LRB- hG-CSF -RRB- gene in Brazil .
16168442	0	hG-CSF	99,105	granulocyte-colony_stimulating_factor	60,97	hG-CSF	granulocyte-colony stimulating factor	1440	1440	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Transgene expression of biological active recombinant human granulocyte-colony_stimulating_factor -LRB- hG-CSF -RRB- into mouse urine .
1724550	0	hG-CSF	66,72	granulocyte_colony-stimulating_factor	27,64	hG-CSF	granulocyte colony-stimulating factor	1440	1440	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Protective effect of human granulocyte_colony-stimulating_factor -LRB- hG-CSF -RRB- on Cryptococcus and Aspergillus_infections in normal and immunosuppressed mice .
1721105	0	hG-CSF	66,72	granulocyte_colony_stimulating_factor	27,64	hG-CSF	granulocyte colony stimulating factor	1440	1440	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Protective effect of human granulocyte_colony_stimulating_factor -LRB- hG-CSF -RRB- on Candida_infections in normal and immunosuppressed mice .
22714276	0	hG-CSF	59,65	granulocyte_colony_stimulating_factor	20,57	hG-CSF	granulocyte colony stimulating factor	1440	1440	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of human granulocyte_colony_stimulating_factor -LRB- hG-CSF -RRB- in colon_adenocarcinoma cell line -LRB- Caco-2 -RRB- .
8892984	0	hGH-N	52,57	growth_hormone	24,38	hGH-N	growth hormone	2688	2688	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of the human growth_hormone normal gene -LRB- hGH-N -RRB- in proliferating and differentiated HL-60 cells .
3146502	0	hGH-RH	40,46	growth_hormone-releasing_hormone	6,38	hGH-RH	growth hormone-releasing hormone	2691	2691	Gene	Gene	treatment|dep|START_ENTITY treatment|amod|END_ENTITY	Human growth_hormone-releasing_hormone -LRB- hGH-RH ; hGRF -RRB- treatment of four patients with GH_deficiency .
10503994	0	hGHR	79,83	growth_hormone_receptor	54,77	hGHR	growth hormone receptor	2690	2690	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Selective amplification of exons 3 and 8 of the human growth_hormone_receptor -LRB- hGHR -RRB- gene based on newly identified intron sequences .
19116246	0	hGHR	61,65	growth_hormone_receptor	36,59	hGHR	growth hormone receptor	2690	2690	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Structure and activity of the human growth_hormone_receptor -LRB- hGHR -RRB- gene V2 promoter .
9440818	0	hGH_receptor	122,134	growth_hormone	30,44	hGH receptor	growth hormone	2690	2688	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	The 20-kilodalton -LRB- kDa -RRB- human growth_hormone -LRB- hGH -RRB- differs from the 22-kDa hGH in the complex formation with cell surface hGH_receptor and hGH-binding protein circulating in human plasma .
15983807	0	hGM-CSF	93,100	granulocyte-macrophage_colony-stimulating_factor	43,91	hGM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Process optimization of constitutive human granulocyte-macrophage_colony-stimulating_factor -LRB- hGM-CSF -RRB- expression in Pichia_pastoris fed-batch culture .
22627758	0	hGM-CSF	91,98	granulocyte-macrophage_colony-stimulating_factor	41,89	hGM-CSF	granulocyte-macrophage colony-stimulating factor	1437	1437	Gene	Gene	Production|dep|START_ENTITY Production|nmod|END_ENTITY	Production and characterization of human granulocyte-macrophage_colony-stimulating_factor -LRB- hGM-CSF -RRB- expressed in the oleaginous yeast Yarrowia_lipolytica .
17653623	0	hGM-CSF	88,95	granulocyte-macrophage_colony_stimulating_factor	38,86	hGM-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Kinetic studies of constitutive human granulocyte-macrophage_colony_stimulating_factor -LRB- hGM-CSF -RRB- expression in continuous culture of Pichia_pastoris .
18804273	0	hGM-CSF	112,119	granulocyte-macrophage_colony_stimulating_factor	62,110	hGM-CSF	granulocyte-macrophage colony stimulating factor	1437	1437	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Production of transgenic recloned piglets harboring the human granulocyte-macrophage_colony_stimulating_factor -LRB- hGM-CSF -RRB- gene from porcine fetal fibroblasts by nuclear transfer .
11437276	0	hGM-CSF	82,89	granulocyte_macrophage-colony_stimulating_factor	32,80	hGM-CSF	granulocyte macrophage-colony stimulating factor	1437	1437	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of recombinant human granulocyte_macrophage-colony_stimulating_factor -LRB- hGM-CSF -RRB- in mouse urine .
26549378	0	hGMCSF	88,94	granulocyte_colony_stimulating_factor	49,86	hGMCSF	granulocyte colony stimulating factor	1437	1440	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of recombinant human granulocyte_colony_stimulating_factor -LRB- hGMCSF -RRB- immobilized onto silica nanoparticles .
1954904	0	hGRH	56,60	growth_hormone-releasing_hormone	22,54	hGRH	growth hormone-releasing hormone	2796	2691	Gene	Gene	Biosynthesis|appos|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of human growth_hormone-releasing_hormone -LRB- hGRH -RRB- in the pituitary of hGRH transgenic_mice .
11243849	0	hHR21	18,23	rad21	6,11	hHR21	rad21	5885	5885	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Human rad21 gene , hHR21 -LRB- SP -RRB- , is downregulated by hypoxia in human tumor cells .
27028861	0	hHR23A	23,29	E2F1	0,4	hHR23A	E2F1	5886	1869	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	E2F1 interactions with hHR23A inhibit its degradation and promote DNA repair .
24318982	0	hHR23A	89,95	RAD23	82,87	hHR23A	RAD23	5886	856674(Tax:4932)	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of HIV-1 Vpr protein to the human homolog of the yeast DNA repair protein RAD23 -LRB- hHR23A -RRB- requires its xeroderma_pigmentosum complementation group C binding -LRB- XPCB -RRB- domain as well as the ubiquitin-associated_2 -LRB- UBA2 -RRB- domain .
21047872	0	hHR23A	88,94	Rad23	81,86	hHR23A	Rad23	5886	856674(Tax:4932)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The crystal structure of the ubiquitin-like -LRB- UbL -RRB- domain of human homologue A of Rad23 -LRB- hHR23A -RRB- protein .
15322280	0	hHR23A	39,45	XPC	17,20	hHR23A	XPC	5886	7508	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Structure of the XPC binding domain of hHR23A reveals hydrophobic patches for protein interaction .
16924240	0	hHR23B	0,6	p53	56,59	hHR23B	p53	5887	7157	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	hHR23B is required for genotoxic-specific activation of p53 and apoptosis .
9469437	0	hIFNAR1	86,93	IFN-alpha	66,75	hIFNAR1	IFN-alpha	3454	3439	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Structure-function study of the extracellular domain of the human IFN-alpha receptor -LRB- hIFNAR1 -RRB- using blocking monoclonal antibodies : the role of domains 1 and 2 .
22358762	0	hIGFBP-1	86,94	insulin-like_growth_factor_binding_protein-1	40,84	hIGFBP-1	insulin-like growth factor binding protein-1	3484	3484	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Stable , recombinant expression of human insulin-like_growth_factor_binding_protein-1 -LRB- hIGFBP-1 -RRB- in Chinese_hamster_ovary -LRB- CHO -RRB- cells .
8548552	0	hIL-1ra	65,72	IL-1_receptor_antagonist	39,63	hIL-1ra	IL-1 receptor antagonist	3557	3557	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Prolonged systemic expression of human IL-1_receptor_antagonist -LRB- hIL-1ra -RRB- in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA .
16256043	0	hIL-4	15,20	E-selectin	42,52	hIL-4	E-selectin	3565	6401	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The effect of hIL-4 on the expression of E-selectin and ICAM-1 on bovine aortic endothelial cells -RSB- .
10036172	0	hIL-5	57,62	interleukin-5	42,55	hIL-5	interleukin-5	3567	3567	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	A scintillation proximity assay for human interleukin-5 -LRB- hIL-5 -RRB- high-affinity binding in insect cells coexpressing hIL-5 receptor alpha and beta subunits .
18226991	0	hIL18	44,49	hTERT	119,124	hIL18	hTERT	3606	7015	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Construction of expression vector of hTERT - hIL18 fusion gene and induction of cytotoxic T lymphocyte response against hTERT .
11196663	0	hIL3	40,44	interleukin-3	25,38	hIL3	interleukin-3	3562	3562	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Two polymorphisms within interleukin-3 -LRB- hIL3 -RRB- gene detected by mismatch PCR/RFLP .
12845660	0	hK11	58,62	kallikrein_11	43,56	hK11	kallikrein 11	11012	11012	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	Favorable prognostic value of tissue human kallikrein_11 -LRB- hK11 -RRB- in patients with ovarian_carcinoma .
17085659	0	hK2	16,19	KLK2	34,38	hK2	KLK2	58164	3817	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of the hK2 protein gene -LRB- KLK2 -RRB- are associated with serum hK2 levels and predict the presence of prostate_cancer at biopsy .
17085659	0	hK2	66,69	KLK2	34,38	hK2	KLK2	58164	3817	Gene	Gene	levels|amod|START_ENTITY associated|nmod|levels associated|nsubjpass|Variants Variants|nmod|gene gene|appos|END_ENTITY	Variants of the hK2 protein gene -LRB- KLK2 -RRB- are associated with serum hK2 levels and predict the presence of prostate_cancer at biopsy .
24270797	0	hK2	72,75	KLK2	21,25	hK2	KLK2	58164	3817	Gene	Gene	concentrations|nmod|START_ENTITY associated|nmod|concentrations associated|nsubjpass|variation variation|nmod|END_ENTITY	Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men .
15555338	0	hK2	45,48	PSMA	50,54	hK2	PSMA	58164	2346	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	-LSB- Clinical significance of expression of PSA , hK2 , PSMA in the peripheral blood of patients with prostate_cancer -RSB- .
9187691	0	hK2	30,33	glandular_kallikrein_2	6,28	hK2	glandular kallikrein 2	58164	3817	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Human glandular_kallikrein_2 -LRB- hK2 -RRB- expression in prostatic_intraepithelial_neoplasia and adenocarcinoma : a novel prostate_cancer marker .
9180162	0	hK2	21,24	urokinase-type_plasminogen_activator	90,126	hK2	urokinase-type plasminogen activator	58164	5328	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Prostatic kallikrein hK2 , but not prostate-specific_antigen -LRB- hK3 -RRB- , activates single-chain urokinase-type_plasminogen_activator .
11334717	0	hLOXL3	67,73	lysyl_oxidase-like_3	40,60	hLOXL3	lysyl oxidase-like 3	84695	84695	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of a human lysyl_oxidase-like_3 gene -LRB- hLOXL3 -RRB- .
8269842	0	hMEF2D	42,48	MEF2	15,19	hMEF2D	MEF2	4209	4205	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	A fourth human MEF2 transcription factor , hMEF2D , is an early marker of the myogenic lineage .
16756717	0	hMLH1	16,21	HOXA5	0,5	hMLH1	HOXA5	4292	3202	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HOXA5 regulates hMLH1 expression in breast_cancer cells .
21747645	0	hMLH1	36,41	INK4A	28,33	hMLH1	INK4A	4292	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Promoter methylation of p16 -LRB- INK4A -RRB- , hMLH1 , and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence .
10480359	0	hMLH1	36,41	hMSH2	43,48	hMLH1	hMSH2	4292	4436	Gene	Gene	hPMS2|compound|START_ENTITY hPMS2|dep|END_ENTITY	Prevalence of germline mutations of hMLH1 , hMSH2 , hPMS1 , hPMS2 , and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal_cancer .
11078826	0	hMLH1	48,53	hMSH2	41,46	hMLH1	hMSH2	4292	4436	Gene	Gene	p16Ink4|dep|START_ENTITY p16Ink4|compound|END_ENTITY	Loss of heterozygosity in adenomyosis on hMSH2 , hMLH1 , p16Ink4 and GALT loci .
11753964	0	hMLH1	26,31	hMSH2	33,38	hMLH1	hMSH2	4292	4436	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	DNA mismatch repair genes hMLH1 , hMSH2 , and hMSH6 are not inactivated in bronchioloalveolar_carcinomas of the lung .
11893037	0	hMLH1	55,60	hMSH2	62,67	hMLH1	hMSH2	4292	4436	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Immunohistochemical screening of mismatch repair genes hMLH1 , hMSH2 , and hMSH6 in dysplastic_lesions_of_the_colon .
12509964	0	hMLH1	58,63	hMSH2	51,56	hMLH1	hMSH2	4292	4436	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15643505	9	hMLH1	1185,1190	hMSH2	1198,1203	hMLH1	hMSH2	4292	4436	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	There was a statistically significant correlation between MSI-positive_tumors and the loss of hMLH1 and/or hMSH2 expression -LRB- p = 0.0286 -RRB- .
9000555	0	hMLH1	68,73	hMSH2	61,66	hMLH1	hMSH2	4292	4436	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Cell cycle regulation of the human DNA mismatch repair genes hMSH2 , hMLH1 , and hPMS2 .
10480359	0	hMLH1	36,41	hPMS1	50,55	hMLH1	hPMS1	4292	5378	Gene	Gene	hPMS2|compound|START_ENTITY hPMS2|dep|END_ENTITY	Prevalence of germline mutations of hMLH1 , hMSH2 , hPMS1 , hPMS2 , and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal_cancer .
11292842	0	hMLH1	59,64	hPMS1	128,133	hMLH1	hPMS1	4292	5378	Gene	Gene	interacts|amod|START_ENTITY interacts|nmod|residues residues|nmod|hMLH3 hMLH3|nummod|END_ENTITY	The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino_acid residues within hMLH3 , hPMS1 and hPMS2 .
12509964	0	hMLH1	58,63	hPMS1	65,70	hMLH1	hPMS1	4292	5378	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
12509964	0	hMLH1	58,63	hPMS2	72,77	hMLH1	hPMS2	4292	5395	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
16256791	0	hMLH1	28,33	mutL_homolog_1	71,85	hMLH1	mutL homolog 1	4292	4292	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Promoter methylation of the hMLH1 gene and protein expression of human mutL_homolog_1 and human mutS_homolog_2 in resected esophageal_squamous_cell_carcinoma .
24571482	0	hMOF	30,34	Nrf2	46,50	hMOF	Nrf2	84148	4780	Gene	Gene	acetylates|nsubj|START_ENTITY acetylates|dobj|END_ENTITY	The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung_cancer .
11506703	0	hMOR	60,64	mu_opioid_receptor	40,58	hMOR	mu opioid receptor	4988	4988	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the human mu_opioid_receptor -LRB- hMOR -RRB- gene : evidence of positive and negative cis-acting elements in the proximal promoter and presence of a distal promoter .
11936871	0	hMOR	84,88	mu_opioid_receptor	64,82	hMOR	mu opioid receptor	4988	4988	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Functional characterization of the promoter region of the human mu_opioid_receptor -LRB- hMOR -RRB- gene : identification of activating and inhibitory regions .
7726159	0	hMSH2	23,28	HNPCC	33,38	hMSH2	HNPCC	4436	4292	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Seven new mutations in hMSH2 , an HNPCC gene , identified by denaturing gradient-gel electrophoresis .
8950986	0	hMSH2	36,41	MutS_homolog_2	20,34	hMSH2	MutS homolog 2	4436	4436	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human MutS_homolog_2 -LRB- hMSH2 -RRB- protein in resting and proliferating cells .
10480359	0	hMSH2	43,48	hMLH1	36,41	hMSH2	hMLH1	4436	4292	Gene	Gene	hPMS2|dep|START_ENTITY hPMS2|compound|END_ENTITY	Prevalence of germline mutations of hMLH1 , hMSH2 , hPMS1 , hPMS2 , and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal_cancer .
11078826	0	hMSH2	41,46	hMLH1	48,53	hMSH2	hMLH1	4436	4292	Gene	Gene	p16Ink4|compound|START_ENTITY p16Ink4|dep|END_ENTITY	Loss of heterozygosity in adenomyosis on hMSH2 , hMLH1 , p16Ink4 and GALT loci .
11753964	0	hMSH2	33,38	hMLH1	26,31	hMSH2	hMLH1	4436	4292	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	DNA mismatch repair genes hMLH1 , hMSH2 , and hMSH6 are not inactivated in bronchioloalveolar_carcinomas of the lung .
11893037	0	hMSH2	62,67	hMLH1	55,60	hMSH2	hMLH1	4436	4292	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Immunohistochemical screening of mismatch repair genes hMLH1 , hMSH2 , and hMSH6 in dysplastic_lesions_of_the_colon .
12509964	0	hMSH2	51,56	hMLH1	58,63	hMSH2	hMLH1	4436	4292	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15643505	9	hMSH2	1198,1203	hMLH1	1185,1190	hMSH2	hMLH1	4436	4292	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	There was a statistically significant correlation between MSI-positive_tumors and the loss of hMLH1 and/or hMSH2 expression -LRB- p = 0.0286 -RRB- .
9000555	0	hMSH2	61,66	hMLH1	68,73	hMSH2	hMLH1	4436	4292	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Cell cycle regulation of the human DNA mismatch repair genes hMSH2 , hMLH1 , and hPMS2 .
10480359	0	hMSH2	43,48	hPMS1	50,55	hMSH2	hPMS1	4436	5378	Gene	Gene	hPMS2|dep|START_ENTITY hPMS2|dep|END_ENTITY	Prevalence of germline mutations of hMLH1 , hMSH2 , hPMS1 , hPMS2 , and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal_cancer .
12509964	0	hMSH2	51,56	hPMS1	65,70	hMSH2	hPMS1	4436	5378	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15918183	0	hMSH2	56,61	hPMS1	30,35	hMSH2	hPMS1	4436	5378	Gene	Gene	hMLH1|appos|START_ENTITY hMLH1|appos|END_ENTITY	Mismatch repair genes -LRB- hMLH1 , hPMS1 , hPMS2 , GTBP/hMSH6 , hMSH2 -RRB- in the pathogenesis of hepatocellular_carcinoma .
12509964	0	hMSH2	51,56	hPMS2	72,77	hMSH2	hPMS2	4436	5395	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15918183	0	hMSH2	56,61	hPMS2	37,42	hMSH2	hPMS2	4436	5395	Gene	Gene	hMLH1|appos|START_ENTITY hMLH1|appos|END_ENTITY	Mismatch repair genes -LRB- hMLH1 , hPMS1 , hPMS2 , GTBP/hMSH6 , hMSH2 -RRB- in the pathogenesis of hepatocellular_carcinoma .
11274057	0	hMSH3	0,5	PCNA	30,34	hMSH3	PCNA	4437	5111	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci .
23725059	0	hMSH4	15,20	eIF3f	39,44	hMSH4	eIF3f	4438	8665	Gene	Gene	START_ENTITY|dep|interaction interaction|nmod|END_ENTITY	MutS homologue hMSH4 : interaction with eIF3f and a role in NHEJ-mediated DSB repair .
26312135	0	hMYH	55,59	hTopBP1	105,112	hMYH	hTopBP1	4595	11073	Gene	Gene	homolog|appos|START_ENTITY homolog|appos|END_ENTITY	A physical association between the human mutY homolog -LRB- hMYH -RRB- and DNA_topoisomerase_II-binding_protein_1 -LRB- hTopBP1 -RRB- regulates Chk1-induced cell cycle arrest in HEK293 cells .
12761891	0	hMad4	0,5	c-Myc	7,12	hMad4	c-Myc	4089	4609	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|amod|END_ENTITY	hMad4 , c-Myc endogenous inhibitor , induces a replicative senescence-like state when overexpressed in human fibroblasts .
9313898	0	hNF-H	70,75	cdk5	116,120	hNF-H	cdk5	4744	1020	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of human high molecular weight neurofilament protein -LRB- hNF-H -RRB- by neuronal cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- .
12519758	1	hNTH1	81,86	APE1	73,77	hNTH1	APE1	4913	328	Gene	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of human APE1 on hNTH1 activity .
15607730	0	hNaS2	94,99	SLC13A4	106,113	hNaS2	SLC13A4	26266	26266	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional characterization and genomic organization of the human Na -LRB- + -RRB- - sulfate cotransporter hNaS2 gene -LRB- SLC13A4 -RRB- .
10964714	0	hOAT1	83,88	organic_anion_transporter_1	54,81	hOAT1	organic anion transporter 1	9356	9356	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genomic structure and in vivo expression of the human organic_anion_transporter_1 -LRB- hOAT1 -RRB- gene .
26170735	0	hOAT7	26,31	SLC22A9	17,24	hOAT7	SLC22A9	114571	114571	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms of SLC22A9 -LRB- hOAT7 -RRB- in Korean Females with Osteoporosis .
21553234	0	hOCT2	23,28	LAPTM4A	0,7	hOCT2	LAPTM4A	6582	9741	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment .
16056251	0	hOGG1	50,55	8-oxoguanine_DNA_glycosylase	20,48	hOGG1	8-oxoguanine DNA glycosylase	4968	4968	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of human 8-oxoguanine_DNA_glycosylase -LRB- hOGG1 -RRB- in follicular_lymphoma .
21727658	0	hOGG1	135,140	8-oxoguanine_DNA_glycosylase	105,133	hOGG1	8-oxoguanine DNA glycosylase	4968	4968	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Protective association exhibited by the single nucleotide polymorphism -LRB- SNP -RRB- rs1052133 in the gene human 8-oxoguanine_DNA_glycosylase -LRB- hOGG1 -RRB- with the risk of squamous_cell_carcinomas of the head _ neck -LRB- SCCHN -RRB- among north Indians .
15650060	0	hOSCAR	39,45	Fc_receptor_gamma-chain	0,23	hOSCAR	Fc receptor gamma-chain	126014	2207	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Fc_receptor_gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses .
25606452	0	hOSCP1	68,74	organic_solute_carrier_protein_1	34,66	hOSCP1	organic solute carrier protein 1	127700	127700	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic polymorphism of the human organic_solute_carrier_protein_1 -LRB- hOSCP1 -RRB- gene in Japanese patients with non-viral_liver_carcinoma .
12898236	0	hOT7T175	120,128	KiSS-1	74,80	hOT7T175	KiSS-1	84634	3814	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor -LRB- hOT7T175 -RRB- gene expression in hepatocellular_carcinoma .
14977840	0	hOT7T175	83,91	KiSS-1	37,43	hOT7T175	KiSS-1	84634	3814	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor -LRB- hOT7T175 -RRB- gene expression in esophageal_squamous_cell_carcinoma .
15901346	0	hOat2	84,89	SLC22A7	91,98	hOat2	SLC22A7	10864	10864	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Transport mechanism and substrate specificity of human organic_anion_transporter_2 -LRB- hOat2 -LSB- SLC22A7 -RSB- -RRB- .
15901346	0	hOat2	84,89	organic_anion_transporter_2	55,82	hOat2	organic anion transporter 2	10864	10864	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|appos|-RSB-	Transport mechanism and substrate specificity of human organic_anion_transporter_2 -LRB- hOat2 -LSB- SLC22A7 -RSB- -RRB- .
16293709	0	hOgg1	79,84	8-oxoguanine_DNA_glycosylase	49,77	hOgg1	8-oxoguanine DNA glycosylase	4968	4968	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	The effect of p53-RNAi and p53 knockout on human 8-oxoguanine_DNA_glycosylase -LRB- hOgg1 -RRB- activity .
18208356	0	hPEM-2	24,30	Smurf1	0,6	hPEM-2	Smurf1	23229	57154	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Smurf1 directly targets hPEM-2 , a GEF for Cdc42 , via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway .
1821515	0	hPL	101,104	IGF-I	64,69	hPL	IGF-I	3956	3479	Gene	Gene	insulin-like_growth_factor-I|appos|START_ENTITY insulin-like_growth_factor-I|appos|END_ENTITY	Maternal plasma concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and human placental_lactogen -LRB- hPL -RRB- in twin pregnancies .
1723674	0	hPL	11,14	SP1	6,9	hPL	SP1	3956	6667	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Serum SP1 , hPL and beta-hCG levels in trophoblastic_diseases .
12942243	0	hPL	37,40	hCG	15,18	hPL	hCG	3956	93659	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of hCG and inhibition of hPL in isolated human trophoblast cells in vitro by glycodelin_A .
3554836	0	hPL	58,61	placental_lactogen	38,56	hPL	placental lactogen	3956	1443	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A pregnancy without detectable human placental_lactogen -LRB- hPL -RRB- -RSB- .
3767004	0	hPL	81,84	placental_lactogen	61,79	hPL	placental lactogen	3956	1443	Gene	Gene	observations|appos|START_ENTITY observations|nmod|secretion secretion|nmod|END_ENTITY	Immunoelectron microscope observations on secretion of human placental_lactogen -LRB- hPL -RRB- in the human chorionic villi .
6851204	0	hPL	52,55	placental_lactogen	32,50	hPL	placental lactogen	3956	1443	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	-LSB- Clinical significance of human placental_lactogen -LRB- hPL -RRB- -RSB- .
7084559	0	hPL	57,60	placental_lactogen	37,55	hPL	placental lactogen	3956	1443	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	The synthesis and secretion of human placental_lactogen -LRB- hPL -RRB- in cultured term placenta .
10571045	0	hPLAP	58,63	phospholipase_A2_activating_protein	21,56	hPLAP	phospholipase A2 activating protein	9373	9373	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the human phospholipase_A2_activating_protein -LRB- hPLAP -RRB- gene on the chromosome 9p21 melanoma deleted region .
20012264	0	hPMAT	64,69	plasma_membrane_monoamine_transporter	25,62	hPMAT	plasma membrane monoamine transporter	222962	222962	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the human plasma_membrane_monoamine_transporter -LRB- hPMAT -RRB- with antidepressants and antipsychotics .
10480359	0	hPMS1	50,55	hMLH1	36,41	hPMS1	hMLH1	5378	4292	Gene	Gene	hPMS2|dep|START_ENTITY hPMS2|compound|END_ENTITY	Prevalence of germline mutations of hMLH1 , hMSH2 , hPMS1 , hPMS2 , and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal_cancer .
11292842	0	hPMS1	128,133	hMLH1	59,64	hPMS1	hMLH1	5378	4292	Gene	Gene	hMLH3|nummod|START_ENTITY residues|nmod|hMLH3 interacts|nmod|residues interacts|amod|END_ENTITY	The interacting domains of three MutL heterodimers in man : hMLH1 interacts with 36 homologous amino_acid residues within hMLH3 , hPMS1 and hPMS2 .
12509964	0	hPMS1	65,70	hMLH1	58,63	hPMS1	hMLH1	5378	4292	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
10480359	0	hPMS1	50,55	hMSH2	43,48	hPMS1	hMSH2	5378	4436	Gene	Gene	hPMS2|dep|START_ENTITY hPMS2|dep|END_ENTITY	Prevalence of germline mutations of hMLH1 , hMSH2 , hPMS1 , hPMS2 , and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal_cancer .
12509964	0	hPMS1	65,70	hMSH2	51,56	hPMS1	hMSH2	5378	4436	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15918183	0	hPMS1	30,35	hMSH2	56,61	hPMS1	hMSH2	5378	4436	Gene	Gene	hMLH1|appos|START_ENTITY hMLH1|appos|END_ENTITY	Mismatch repair genes -LRB- hMLH1 , hPMS1 , hPMS2 , GTBP/hMSH6 , hMSH2 -RRB- in the pathogenesis of hepatocellular_carcinoma .
12509964	0	hPMS1	65,70	hPMS2	72,77	hPMS1	hPMS2	5378	5395	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15918183	0	hPMS1	30,35	hPMS2	37,42	hPMS1	hPMS2	5378	5395	Gene	Gene	hMLH1|appos|START_ENTITY hMLH1|appos|END_ENTITY	Mismatch repair genes -LRB- hMLH1 , hPMS1 , hPMS2 , GTBP/hMSH6 , hMSH2 -RRB- in the pathogenesis of hepatocellular_carcinoma .
12509964	0	hPMS2	72,77	hMLH1	58,63	hPMS2	hMLH1	5395	4292	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
12509964	0	hPMS2	72,77	hMSH2	51,56	hPMS2	hMSH2	5395	4436	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15918183	0	hPMS2	37,42	hMSH2	56,61	hPMS2	hMSH2	5395	4436	Gene	Gene	hMLH1|appos|START_ENTITY hMLH1|appos|END_ENTITY	Mismatch repair genes -LRB- hMLH1 , hPMS1 , hPMS2 , GTBP/hMSH6 , hMSH2 -RRB- in the pathogenesis of hepatocellular_carcinoma .
12509964	0	hPMS2	72,77	hPMS1	65,70	hPMS2	hPMS1	5395	5378	Gene	Gene	loci|nummod|START_ENTITY loci|nummod|END_ENTITY	Allelic imbalance at the DNA mismatch repair loci , hMSH2 , hMLH1 , hPMS1 , hPMS2 and hMSH3 , in squamous_cell_carcinoma of the head_and_neck .
15918183	0	hPMS2	37,42	hPMS1	30,35	hPMS2	hPMS1	5395	5378	Gene	Gene	hMLH1|appos|START_ENTITY hMLH1|appos|END_ENTITY	Mismatch repair genes -LRB- hMLH1 , hPMS1 , hPMS2 , GTBP/hMSH6 , hMSH2 -RRB- in the pathogenesis of hepatocellular_carcinoma .
22550474	0	hPPAR	74,79	PPAR	32,36	hPPAR	PPAR	5465	5465	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Conditional Expression of Human PPAR and a Dominant Negative Variant of hPPAR In Vivo .
9168928	0	hPPAR_gamma	118,129	peroxisome_proliferator_activated_receptor-gamma	68,116	hPPAR gamma	peroxisome proliferator activated receptor-gamma	5468	5468	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Chromosomal localization and partial genomic structure of the human peroxisome_proliferator_activated_receptor-gamma -LRB- hPPAR_gamma -RRB- gene .
9425261	0	hPPAR_gamma	82,93	peroxisome_proliferator_activated_receptor_gamma	32,80	hPPAR gamma	peroxisome proliferator activated receptor gamma	5468	5468	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Molecular scanning of the human peroxisome_proliferator_activated_receptor_gamma -LRB- hPPAR_gamma -RRB- gene in diabetic Caucasians : identification of a Pro12Ala PPAR_gamma 2 missense mutation .
11117526	0	hPR-B	87,92	IGFBP-1	115,122	hPR-B	IGFBP-1	5925	3484	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Ligand-activated progesterone_receptor isoform hPR-A is a stronger transactivator than hPR-B for the expression of IGFBP-1 -LRB- insulin-like_growth_factor_binding_protein-1 -RRB- in human endometrial stromal cells .
9693065	0	hPTH	52,56	parathyroid_hormone	31,50	hPTH	parathyroid hormone	5741	5741	Gene	Gene	production|appos|START_ENTITY production|nmod|END_ENTITY	High-level production of human parathyroid_hormone -LRB- hPTH -RRB- by induced expression in Saccharomyces_cerevisiae .
22002306	0	hPTTG1	14,20	RhoA	94,98	hPTTG1	RhoA	9232	387	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	Overexpressed hPTTG1 promotes breast_cancer cell invasion and metastasis by regulating GEF-H1 / RhoA signalling .
22291441	0	hPar1	51,56	protease-activated_receptor_1	20,49	hPar1	protease-activated receptor 1	2149	2149	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Regulation of human protease-activated_receptor_1 -LRB- hPar1 -RRB- gene expression in breast_cancer by estrogen .
9315667	0	hPc2	68,72	polycomb	50,58	hPc2	polycomb	8535	40358(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Interference with the expression of a novel human polycomb protein , hPc2 , results in cellular transformation and apoptosis .
17498647	0	hPepT1	25,31	SLC15A1	33,40	hPepT1	SLC15A1	6564	6564	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regulation of intestinal hPepT1 -LRB- SLC15A1 -RRB- activity by phosphodiesterase inhibitors is via inhibition of NHE3 -LRB- SLC9A3 -RRB- .
22166120	0	hPer2	50,55	Period2	41,48	hPer2	Period2	8864	8864	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of circadian clock gene human Period2 -LRB- hPer2 -RRB- in human colorectal_carcinoma .
10899582	0	hPhLP	76,81	phosducin-like_protein	52,74	hPhLP	phosducin-like protein	5132	5132	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Molecular cloning and characterization of the human phosducin-like_protein -LRB- hPhLP -RRB- promoter .
24675077	0	hPso4	34,39	psoralen_4	22,32	hPso4	psoralen 4	27339	27339	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The role of the human psoralen_4 -LRB- hPso4 -RRB- protein complex in replication stress and homologous recombination .
23284001	0	hPygopus2	83,92	Elf-1	108,113	hPygopus2	Elf-1	90780	1997	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Human_papilloma_virus -LRB- HPV -RRB- E7-mediated attenuation of retinoblastoma -LRB- Rb -RRB- induces hPygopus2 expression via Elf-1 in cervical_cancer .
17868694	0	hQPRTase	82,90	quinolinate_phosphoribosyltransferase	43,80	hQPRTase	quinolinate phosphoribosyltransferase	23475	23475	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Structural and kinetic characterization of quinolinate_phosphoribosyltransferase -LRB- hQPRTase -RRB- from homo_sapiens .
12750285	0	hRAD51	19,25	p53	0,3	hRAD51	p53	5888	7157	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	p53 interacts with hRAD51 and hRAD54 , and directly modulates homologous recombination .
11485998	0	hREV1	64,69	hREV3	71,76	hREV1	hREV3	51455	5980	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Interactions in the error-prone postreplication repair proteins hREV1 , hREV3 , and hREV7 .
11485998	0	hREV3	71,76	hREV1	64,69	hREV3	hREV1	5980	51455	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Interactions in the error-prone postreplication repair proteins hREV1 , hREV3 , and hREV7 .
24761851	0	hRFT2	56,61	riboflavin_transporter_2	31,55	hRFT2	riboflavin transporter 2	113278	113278	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of human riboflavin_transporter_2 -LRB- hRFT2 -RRB- in cervical_cancers from Uighur women .
14986927	0	hRTN3	37,42	reticulon_3	24,35	hRTN3	reticulon 3	10313	10313	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of human reticulon_3 -LRB- hRTN3 -RRB- in astrocytoma .
10884395	0	hRad1	74,79	hRad17	29,35	hRad1	hRad17	5810	5884	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1 , hHus1 , and hRad9 .
10884395	0	hRad17	29,35	hRad1	74,79	hRad17	hRad1	5884	5810	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1 , hHus1 , and hRad9 .
16018971	0	hRad51	51,57	hRad52	84,90	hRad51	hRad52	5888	5893	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of DNA sequence and nucleotide cofactors on hRad51 binding to ssDNA : role of hRad52 in recruitment .
16018971	0	hRad52	84,90	hRad51	51,57	hRad52	hRad51	5893	5888	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of DNA sequence and nucleotide cofactors on hRad51 binding to ssDNA : role of hRad52 in recruitment .
11545594	0	hRap1	21,26	Myb	27,30	hRap1	Myb	54386	4602	Gene	Gene	motif|amod|START_ENTITY motif|compound|END_ENTITY	NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains .
23511974	0	hSAS-6	43,49	CEP135	27,33	hSAS-6	CEP135	163786	9662	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human microcephaly protein CEP135 binds to hSAS-6 and CPAP , and is required for centriole assembly .
9802570	0	hSEP1	44,49	Sep1	38,42	hSEP1	Sep1	54464	54464	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and characterization of human Sep1 -LRB- hSEP1 -RRB- gene and cytoplasmic localization of its product .
9322234	0	hSERT	81,86	serotonin_transporter	53,74	hSERT	serotonin transporter	6532	6532	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Association studies of bipolar_disorder at the human serotonin_transporter gene -LRB- hSERT ; 5HTT -RRB- .
17135299	0	hSMVT	43,48	KLF-4	61,66	hSMVT	KLF-4	8884	9314	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2 : confirmation of promoter activity in vivo .
9730600	0	hSNF2H	40,46	ISWI	86,90	hSNF2H	ISWI	8467	36390(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Cloning and mapping of SMARCA5 encoding hSNF2H , a novel human homologue of Drosophila ISWI .
2303034	0	hSP	0,3	pS2	38,41	hSP	pS2	7190	338412	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|protein protein|amod|END_ENTITY	hSP , the domain-duplicated homolog of pS2 protein , is co-expressed with pS2 in stomach but not in breast_carcinoma .
2303034	0	hSP	0,3	pS2	72,75	hSP	pS2	7190	338412	Gene	Gene	co-expressed|nsubjpass|START_ENTITY co-expressed|nmod|END_ENTITY	hSP , the domain-duplicated homolog of pS2 protein , is co-expressed with pS2 in stomach but not in breast_carcinoma .
9050913	0	hSP	98,101	pS2	55,58	hSP	pS2	7190	7031	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Close physical linkage of the genes encoding the pNR-2 / pS2 protein and human spasmolytic protein -LRB- hSP -RRB- .
21567072	0	hSav1	0,5	HAX1	21,25	hSav1	HAX1	60485	10456	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	hSav1 interacts with HAX1 and attenuates its anti-apoptotic effects in MCF-7 breast_cancer cells .
15975580	0	hScrib	0,6	ZO-2	22,26	hScrib	ZO-2	23513	9414	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	hScrib interacts with ZO-2 at the cell-cell junctions of epithelial cells .
16956364	0	hSfi1	54,59	centrin_2	17,26	hSfi1	centrin 2	9814	1069	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of human centrin_2 to the centrosomal protein hSfi1 .
16760435	0	hSos1	66,71	Grb2	0,4	hSos1	Grb2	6654	2885	Gene	Gene	activity|nmod|START_ENTITY modulator|nmod|activity modulator|nsubj|END_ENTITY	Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1 .
7629168	0	hSos1	69,74	Grb2	140,144	hSos1	Grb2	6654	2885	Gene	Gene	phospholipase_C-gamma_1|amod|START_ENTITY phospholipase_C-gamma_1|nmod|END_ENTITY	Ligation of the T-cell_antigen_receptor -LRB- TCR -RRB- induces association of hSos1 , ZAP-70 , phospholipase_C-gamma_1 , and other phosphoproteins with Grb2 and the zeta-chain of the TCR .
8479541	0	hSos1	36,41	Grb2	51,55	hSos1	Grb2	6654	2885	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling .
8649768	0	hSos1	94,99	Grb2	133,137	hSos1	Grb2	6654	2885	Gene	Gene	isoforms|amod|START_ENTITY expressed|dobj|isoforms expressed|nmod|affinity affinity|amod|END_ENTITY	A 15 amino_acid stretch close to the Grb2-binding domain defines two differentially expressed hSos1 isoforms with markedly different Grb2 binding affinity and biological activity .
11575923	0	hSpt5	50,55	Pin1	30,34	hSpt5	Pin1	6829	5300	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9 .
8758937	0	hTAFII100	20,29	TFIIF_beta	96,106	hTAFII100	TFIIF beta	6877	2963	Gene	Gene	domains|nmod|START_ENTITY required|nsubjpass|domains required|nmod|END_ENTITY	Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF_beta -LRB- RAP30 -RRB- and incorporation into the TFIID complex .
25984768	0	hTE	44,47	tropoelastin	30,42	hTE	tropoelastin	10005	2006	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of synthetic human tropoelastin -LRB- hTE -RRB- protein in Nicotiana_tabacum .
25984768	0	hTE	44,47	tropoelastin	30,42	hTE	tropoelastin	10005	2006	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of synthetic human tropoelastin -LRB- hTE -RRB- protein in Nicotiana_tabacum .
22151181	0	hTERT	14,19	BCR-ABL	23,30	hTERT	BCR-ABL	7015	25	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hTERT by BCR-ABL at multiple levels in K562 cells .
25301947	0	hTERT	67,72	BRIT1	74,79	hTERT	BRIT1	7015	79648	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Phosphorylation of the BRCA1 C terminus -LRB- BRCT -RRB- repeat inhibitor of hTERT -LRB- BRIT1 -RRB- protein coordinates TopBP1 protein recruitment and amplifies ataxia_telangiectasia-mutated_and_Rad3-related -LRB- ATR -RRB- Signaling .
12586632	0	hTERT	8,13	CD4	56,59	hTERT	CD4	7015	920	Gene	Gene	expression|compound|START_ENTITY extends|nsubj|expression extends|dobj|span span|nmod|helper helper|compound|END_ENTITY	Ectopic hTERT expression extends the life span of human CD4 + helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis .
22934259	0	hTERT	113,118	CD4	11,14	hTERT	CD4	7015	920	Gene	Gene	GV1001|compound|START_ENTITY patients|nmod|GV1001 vaccination|nmod|patients epitopes|nmod|vaccination epitopes|nsubj|reactivity reactivity|compound|END_ENTITY	Widespread CD4 + T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001 .
22934259	0	hTERT	43,48	CD4	11,14	hTERT	CD4	7015	920	Gene	Gene	reactivity|nmod|START_ENTITY reactivity|compound|END_ENTITY	Widespread CD4 + T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001 .
26662465	0	hTERT	9,14	CD4	46,49	hTERT	CD4	7015	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Declined hTERT expression of peripheral blood CD4 -LRB- + -RRB- T cells in oral lichen planus correlated with clinical parameter .
15331176	0	hTERT	99,104	COUP-TFII	39,48	hTERT	COUP-TFII	7015	7026	Gene	Gene	transcription|compound|START_ENTITY inhibiting|nmod|transcription END_ENTITY|xcomp|inhibiting	The evidences of human orphan receptor COUP-TFII inhibiting telomerase activity through decreasing hTERT transcription .
15506639	0	hTERT	67,72	COUP-TFII	40,49	hTERT	COUP-TFII	7015	7026	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Inhibitory role of transcription factor COUP-TFII in expression of hTERT in HeLa cells .
21867613	0	hTERT	12,17	Cyclin_D1	1,10	hTERT	Cyclin D1	7015	595	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	-LSB- Cyclin_D1 , hTERT expression and telomerase activity in HL-60 and HL-60A cell lines and their significance -RSB- .
19384955	0	hTERT	43,48	DJ-1	19,23	hTERT	DJ-1	7015	11315	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	The PTEN regulator DJ-1 is associated with hTERT expression in clear_cell_renal_cell_carcinoma .
19751963	0	hTERT	101,106	Hsp90	73,78	hTERT	Hsp90	7015	3320	Gene	Gene	dissociating|nmod|START_ENTITY dissociating|dobj|p23 p23|amod|END_ENTITY	Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT .
19015635	0	hTERT	18,23	MSH2	45,49	hTERT	MSH2	7015	4436	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Regulation of the hTERT promoter activity by MSH2 , the hnRNPs_K_and_D , and GRHL2 in human oral_squamous_cell_carcinoma cells .
19102213	0	hTERT	169,174	MUC1	128,132	hTERT	MUC1	7015	4582	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The preparation of myeloma-specific T cells activated with dendritic cells loaded with nonapeptides derived from mucin protein MUC1 and catalytic subunit of telomerase hTERT -RSB- .
22709411	0	hTERT	17,22	MiR-21	0,6	hTERT	MiR-21	7015	406991	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	MiR-21 modulates hTERT through a STAT3-dependent manner on glioblastoma cell growth .
26585488	0	hTERT	80,85	MiR-661	0,7	hTERT	MiR-661	7015	724031	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-661 inhibits glioma cell proliferation , migration and invasion by targeting hTERT .
24817011	0	hTERT	22,27	MicroRNA-21	0,11	hTERT	MicroRNA-21	7015	406991	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-21 regulates hTERT via PTEN in hypertrophic_scar_fibroblasts .
25603978	0	hTERT	21,26	MicroRNA-21	0,11	hTERT	MicroRNA-21	7015	406991	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	MicroRNA-21 controls hTERT via PTEN in human colorectal_cancer cell proliferation .
18511807	0	hTERT	54,59	PI3K	16,20	hTERT	PI3K	7015	5293	Gene	Gene	activation|nmod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells .
20011463	0	hTERT	62,67	Telomerase_Reverse_Transcriptase	28,60	hTERT	Telomerase Reverse Transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	In silico analysis of human Telomerase_Reverse_Transcriptase -LRB- hTERT -RRB- gene : identification of a distant homolog of Melanoma Antigen Family Gene -LRB- MAGE -RRB- .
25854384	0	hTERT	64,69	Telomerase_Reverse_Transcriptase	30,62	hTERT	Telomerase Reverse Transcriptase	7015	7015	Gene	Gene	Expression|appos|START_ENTITY Expression|compound|END_ENTITY	Prognostic Relevance of Human Telomerase_Reverse_Transcriptase -LRB- hTERT -RRB- Expression in Patients with Gall_Bladder_Disease_and_Carcinoma .
16020509	0	hTERT	37,42	Tumor_necrosis_factor-alpha	0,27	hTERT	Tumor necrosis factor-alpha	7015	7124	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells .
14738567	0	hTERT	23,28	VEGF	72,76	hTERT	VEGF	7015	7422	Gene	Gene	expression|nmod|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|compound|END_ENTITY	The mRNA expression of hTERT in human breast_carcinomas correlates with VEGF expression .
23869238	0	hTERT	23,28	VEGF	50,54	hTERT	VEGF	7015	7422	Gene	Gene	START_ENTITY|dep|Signaling Signaling|compound|END_ENTITY	Berberine Targets AP-2 / hTERT , NF-kB/COX -2 , HIF-1a / VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth .
25000517	0	hTERT	19,24	c-MYC	55,60	hTERT	c-MYC	7015	4609	Gene	Gene	expression|amod|START_ENTITY potentiates|dobj|expression potentiates|advcl|activating activating|xcomp|END_ENTITY	FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast .
10637317	0	hTERT	104,109	c-Myc	20,25	hTERT	c-Myc	7015	4609	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene -LRB- hTERT -RRB- .
12082531	0	hTERT	18,23	c-Myc	68,73	hTERT	c-Myc	7015	4609	Gene	Gene	Reconstitution|nmod|START_ENTITY restores|nsubj|Reconstitution restores|nmod|clones clones|amod|END_ENTITY	Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones .
14563552	0	hTERT	36,41	c-Myc	46,51	hTERT	c-Myc	7015	4609	Gene	Gene	telomerase|appos|START_ENTITY telomerase|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Induction of endogenous telomerase -LRB- hTERT -RRB- by c-Myc in WI-38 fibroblasts transformed with specific genetic elements .
16785237	0	hTERT	83,88	c-Myc	117,122	hTERT	c-Myc	7015	4609	Gene	Gene	suppresses|dep|START_ENTITY suppresses|nmod|interactions interactions|nmod|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
18586674	0	hTERT	15,20	c-Myc	94,99	hTERT	c-Myc	7015	4609	Gene	Gene	expression|amod|START_ENTITY maintains|dobj|expression maintains|advcl|interacting interacting|advcl|END_ENTITY	Ets2 maintains hTERT gene expression and breast_cancer cell proliferation by interacting with c-Myc .
20454512	0	hTERT	86,91	c-Myc	21,26	hTERT	c-Myc	7015	4609	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression .
22207128	0	hTERT	40,45	c-Myc	105,110	hTERT	c-Myc	7015	4609	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|cells cells|nmod|activation activation|nmod|END_ENTITY	E2F1 : a potential negative regulator of hTERT transcription in normal cells upon activation of oncogenic c-Myc .
23860446	0	hTERT	26,31	c-Myc	93,98	hTERT	c-Myc	7015	379052(Tax:8355)	Gene	Gene	promoter|amod|START_ENTITY dynamics|nmod|promoter dynamics|nmod|END_ENTITY	Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus_leavis oocytes .
24969314	0	hTERT	62,67	c-Myc	46,51	hTERT	c-Myc	7015	4609	Gene	Gene	transcription|compound|START_ENTITY acts|dep|transcription acts|nmod|regulator regulator|nmod|END_ENTITY	E2F1 acts as a negative feedback regulator of c-Myc - induced hTERT transcription during tumorigenesis .
25170084	0	hTERT	41,46	c-Myc	14,19	hTERT	c-Myc	7015	4609	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene roles|nmod|regulation roles|nmod|END_ENTITY	Dual roles of c-Myc in the regulation of hTERT gene .
26689987	0	hTERT	40,45	c-Myc	105,110	hTERT	c-Myc	7015	4609	Gene	Gene	telomerase_reverse_transcriptase|appos|START_ENTITY promotes|nsubj|telomerase_reverse_transcriptase promotes|advcl|cooperating cooperating|advcl|END_ENTITY	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- promotes gastric_cancer invasion through cooperating with c-Myc to upregulate heparanase expression .
14570602	0	hTERT	25,30	c-myc	92,97	hTERT	c-myc	7015	4609	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Expression of telomerase hTERT in human non-small cell lung_cancer and its correlation with c-myc gene .
25873431	0	hTERT	30,35	c-myc	51,56	hTERT	c-myc	7015	4609	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Acidified bile_acids increase hTERT expression via c-myc activation in human gastric_cancer cells .
25873431	0	hTERT	30,35	c-myc	51,56	hTERT	c-myc	7015	4609	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Acidified bile_acids increase hTERT expression via c-myc activation in human gastric_cancer cells .
18226991	0	hTERT	119,124	hIL18	44,49	hTERT	hIL18	7015	3606	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Construction of expression vector of hTERT - hIL18 fusion gene and induction of cytotoxic T lymphocyte response against hTERT .
15665594	0	hTERT	34,39	hTR	66,69	hTERT	hTR	7015	7012	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	Telomerase reverse transcriptase -LRB- hTERT -RRB- mRNA and telomerase RNA -LRB- hTR -RRB- as targets for downregulation of telomerase activity .
12151407	0	hTERT	108,113	histone_deacetylase	20,39	hTERT	histone deacetylase	7015	9734	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Sp1 and Sp3 recruit histone_deacetylase to repress transcription of human telomerase reverse transcriptase -LRB- hTERT -RRB- promoter in normal human somatic cells .
18820283	0	hTERT	28,33	hsp90	15,20	hTERT	hsp90	7015	3320	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral_cancer cells .
18820283	0	hTERT	60,65	hsp90	15,20	hTERT	hsp90	7015	3320	Gene	Gene	expression|amod|START_ENTITY necessary|nmod|expression necessary|nsubj|Association Association|nmod|END_ENTITY	Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral_cancer cells .
17562265	0	hTERT	16,21	maspin	36,42	hTERT	maspin	7015	5268	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	-LSB- Correlation of hTERT expression to maspin and bFGF expression and their significance in glioma -RSB- .
26772886	0	hTERT	90,95	miR-1182	0,8	hTERT	miR-1182	7015	100302132	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	miR-1182 inhibits growth and mediates the chemosensitivity of bladder_cancer by targeting hTERT .
25643913	0	hTERT	18,23	miR-19b	0,7	hTERT	miR-19b	7015	406980	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells .
19751963	0	hTERT	101,106	p23	92,95	hTERT	p23	7015	10728	Gene	Gene	dissociating|nmod|START_ENTITY dissociating|dobj|END_ENTITY	Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT .
11497281	0	hTERT	64,69	telomerase_catalytic_subunit	34,62	hTERT	telomerase catalytic subunit	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	FADD gene therapy using the human telomerase_catalytic_subunit -LRB- hTERT -RRB- gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo .
12209957	0	hTERT	60,65	telomerase_catalytic_subunit	30,58	hTERT	telomerase catalytic subunit	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hypermethylation of the human telomerase_catalytic_subunit -LRB- hTERT -RRB- gene correlates with telomerase activity .
15322345	0	hTERT	52,57	telomerase_catalytic_subunit	22,50	hTERT	telomerase catalytic subunit	7015	7015	Gene	Gene	Activity|dep|START_ENTITY Activity|nmod|END_ENTITY	Activity of the human telomerase_catalytic_subunit -LRB- hTERT -RRB- gene promoter could be increased by the SV40 enhancer .
10220433	0	hTERT	75,80	telomerase_reverse_transcriptase	41,73	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Constitutive and regulated expression of telomerase_reverse_transcriptase -LRB- hTERT -RRB- in human lymphocytes .
10626795	0	hTERT	95,100	telomerase_reverse_transcriptase	61,93	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	DNA methylation analysis of the promoter region of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene .
10861477	0	hTERT	62,67	telomerase_reverse_transcriptase	28,60	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Quantitative measurement of telomerase_reverse_transcriptase -LRB- hTERT -RRB- mRNA in urothelial_cell_carcinomas .
11290757	0	hTERT	122,127	telomerase_reverse_transcriptase	88,120	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Cutting edge : telomerase activation in human T lymphocytes does not require increase in telomerase_reverse_transcriptase -LRB- hTERT -RRB- protein but is associated with hTERT phosphorylation and nuclear translocation .
11855854	0	hTERT	99,104	telomerase_reverse_transcriptase	65,97	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The histone deacetylase inhibitor trichostatin_A derepresses the telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in human cells .
12032853	0	hTERT	60,65	telomerase_reverse_transcriptase	26,58	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Tamoxifen regulates human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene expression differently in breast and endometrial_cancer cells .
12566315	0	hTERT	80,85	telomerase_reverse_transcriptase	46,78	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A chromosome 3-encoded repressor of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene controls the state of hTERT chromatin .
12802289	0	hTERT	124,129	telomerase_reverse_transcriptase	90,122	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Integrations of the hepatitis_B virus -LRB- HBV -RRB- and human_papillomavirus _ -LRB- HPV -RRB- into the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in liver_and_cervical_cancers .
15026805	0	hTERT	61,66	telomerase_reverse_transcriptase	27,59	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of telomerase_reverse_transcriptase -LRB- hTERT -RRB- in lung_tumours .
15142451	0	hTERT	66,71	telomerase_reverse_transcriptase	32,64	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	-LSB- Inhibition of anti-sense human telomerase_reverse_transcriptase -LRB- hTERT -RRB- retroviral vector on lung_cancer cells -RSB- .
16061629	0	hTERT	109,114	telomerase_reverse_transcriptase	75,107	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- regulates human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in human cancer and primary cells .
16708388	0	hTERT	74,79	telomerase_reverse_transcriptase	40,72	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Enhanced antitumor effect against human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by vaccination with chemotactic-hTERT gene-modified tumor cell and the combination with anti-4-1BB monoclonal antibodies .
16785237	0	hTERT	83,88	telomerase_reverse_transcriptase	49,81	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	suppresses|dep|START_ENTITY suppresses|dobj|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
16798059	0	hTERT	54,59	telomerase_reverse_transcriptase	20,52	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- protein is significantly associated with the progression , recurrence and prognosis of oral_squamous_cell_carcinoma in Taiwan .
17204238	0	hTERT	135,140	telomerase_reverse_transcriptase	101,133	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- mRNA .
17429837	0	hTERT	67,72	telomerase_reverse_transcriptase	33,65	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of heterozygosity and human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in bronchial mucosa of heavy smokers .
18154939	0	hTERT	53,58	telomerase_reverse_transcriptase	19,51	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Detection of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in tissue and pancreatic juice from pancreatic_cancer .
18161862	0	hTERT	163,168	telomerase_reverse_transcriptase	129,161	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Mixed ductal-endocrine_carcinoma derived from intraductal_papillary_mucinous_neoplasm -LRB- IPMN -RRB- of the pancreas identified by human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression .
18197256	0	hTERT	125,130	telomerase_reverse_transcriptase	91,123	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Lysine-specific_demethylase_1 -LRB- LSD1 -RRB- Is required for the transcriptional repression of the telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene .
18204433	0	hTERT	84,89	telomerase_reverse_transcriptase	50,82	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Distribution and prognostic significance of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in giant-cell_tumor_of_bone .
18422743	0	hTERT	108,113	telomerase_reverse_transcriptase	74,106	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Role of human_T-cell_leukemia_virus_type_I Tax in expression of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in human T-cells .
19301721	0	hTERT	40,45	telomerase_reverse_transcriptase	6,38	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in borderline_ovarian_tumors : an immunohistochemical study .
19843528	0	hTERT	30,35	telomerase_reverse_transcriptase	47,79	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Transcriptional activation of hTERT , the human telomerase_reverse_transcriptase , by nuclear factor of activated T cells .
20052289	0	hTERT	134,139	telomerase_reverse_transcriptase	100,132	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Interferon-inducible IFI16 , a negative regulator of cell growth , down-regulates expression of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene .
20814747	0	hTERT	124,129	telomerase_reverse_transcriptase	90,122	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	p21 WAF1 is involved in interferon-b-induced attenuation of telomerase activity and human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in ovarian_cancer .
26487723	0	hTERT	40,45	telomerase_reverse_transcriptase	6,38	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	transcription|compound|START_ENTITY transcription|amod|END_ENTITY	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- transcription requires Sp1/Sp3 binding to the promoter and a permissive chromatin environment .
27016301	0	hTERT	57,62	telomerase_reverse_transcriptase	23,55	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	START_ENTITY|nsubj|Polymorphisms Polymorphisms|nmod|END_ENTITY	Polymorphisms in human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene and susceptibility to gastric_cancer in a Turkish population : Hospital-based case-control study .
9751630	0	hTERT	97,102	telomerase_reverse_transcriptase	63,95	hTERT	telomerase reverse transcriptase	7015	7015	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Telomerase activity in human development is regulated by human telomerase_reverse_transcriptase -LRB- hTERT -RRB- transcription and by alternate splicing of hTERT transcripts .
16628468	0	hTNF-alpha	52,62	estrogen_receptor-alpha	15,38	hTNF-alpha	estrogen receptor-alpha	7124	2099	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Over-expressed estrogen_receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon_cancer cells .
9588867	0	hTNFalpha	70,79	tumor_necrosis_factor-alpha	41,68	hTNFalpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	evaluation|appos|START_ENTITY evaluation|nmod|END_ENTITY	In vitro and in vivo evaluation of human tumor_necrosis_factor-alpha -LRB- hTNFalpha -RRB- chemically conjugated to monoclonal antibody .
15824061	0	hTR	38,41	Ku70/80	6,13	hTR	Ku70/80	7012	2547;7520	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human Ku70/80 interacts directly with hTR , the RNA component of human telomerase .
15665594	0	hTR	66,69	hTERT	34,39	hTR	hTERT	7012	7015	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	Telomerase reverse transcriptase -LRB- hTERT -RRB- mRNA and telomerase RNA -LRB- hTR -RRB- as targets for downregulation of telomerase activity .
26481359	0	hTR	64,67	telomerase_reverse_transcriptase	6,38	hTR	telomerase reverse transcriptase	7012	7015	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human telomerase_reverse_transcriptase binds to a pre-organized hTR in vivo exposing its template .
9430820	0	hTRH	29,33	TRH	24,27	hTRH	TRH	7200	7200	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Regulation of the human TRH -LRB- hTRH -RRB- gene by human thyroid_hormone receptor beta 1 -LRB- hTR beta 1 -RRB- mutants .
7919995	0	hTSHR	54,59	thyrotropin_receptor	32,52	hTSHR	thyrotropin receptor	7253	7253	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphism of a variant human thyrotropin_receptor -LRB- hTSHR -RRB- gene .
11854491	0	hTid-1	24,30	DnaJ	10,14	hTid-1	DnaJ	9093	85406	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	The human DnaJ protein , hTid-1 , enhances binding of a multimer of the herpes_simplex_virus_type_1 UL9 protein to oris , an origin of viral DNA replication .
21106534	0	hTid1	21,26	STAT5b	36,42	hTid1	STAT5b	9093	6777	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction .
26312135	0	hTopBP1	105,112	hMYH	55,59	hTopBP1	hMYH	11073	4595	Gene	Gene	homolog|appos|START_ENTITY homolog|appos|END_ENTITY	A physical association between the human mutY homolog -LRB- hMYH -RRB- and DNA_topoisomerase_II-binding_protein_1 -LRB- hTopBP1 -RRB- regulates Chk1-induced cell cycle arrest in HEK293 cells .
9488727	0	hUBC9	94,99	ATF2	50,54	hUBC9	ATF2	7329	1386	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of activating_transcription_factor_2 -LRB- ATF2 -RRB- with the ubiquitin-conjugating enzyme hUBC9 .
11085938	0	hUBC9	121,126	FHIT	15,19	hUBC9	FHIT	7329	2272	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of FHIT -LRB- fragile histidine triad -RRB- , a candidate tumour suppressor gene , with the ubiquitin-conjugating enzyme hUBC9 .
9488727	0	hUBC9	94,99	activating_transcription_factor_2	15,48	hUBC9	activating transcription factor 2	7329	1386	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of activating_transcription_factor_2 -LRB- ATF2 -RRB- with the ubiquitin-conjugating enzyme hUBC9 .
10027754	0	hUCP2	83,88	uncoupling_protein-2	61,81	hUCP2	uncoupling protein-2	7351	7351	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structural organization and mutational analysis of the human uncoupling_protein-2 -LRB- hUCP2 -RRB- gene .
22266335	0	hUCP2	58,63	uncoupling_protein_2	36,56	hUCP2	uncoupling protein 2	7351	7351	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A neuroprotective role of the human uncoupling_protein_2 -LRB- hUCP2 -RRB- in a Drosophila Parkinson 's _ disease model .
24965893	0	hUCP2	58,63	uncoupling_protein_2	36,56	hUCP2	uncoupling protein 2	7351	7351	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The neuroprotective effect of human uncoupling_protein_2 -LRB- hUCP2 -RRB- requires cAMP-dependent protein kinase in a toxin model of Parkinson 's _ disease .
11045607	0	hUCP3	90,95	UCP3	84,88	hUCP3	UCP3	7352	7352	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Functional characterization of the 5 ' - flanking and the promoter region of the human UCP3 -LRB- hUCP3 -RRB- gene .
19833602	0	hURAT1	75,81	urate_transporter_1	54,73	hURAT1	urate transporter 1	116085	116085	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Multiple single_nucleotide_polymorphisms in the human urate_transporter_1 -LRB- hURAT1 -RRB- gene are associated with hyperuricaemia in Han Chinese .
18774934	0	hUpf1	42,47	ZNF268	19,25	hUpf1	ZNF268	5976	10795	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The mammalian gene ZNF268 is regulated by hUpf1 .
19015334	0	hVISA	89,94	VISA	136,140	hVISA	VISA	57506	57506	Gene	Gene	Impact|appos|START_ENTITY Impact|nmod|END_ENTITY	Impact of inoculum size and heterogeneous vancomycin-intermediate Staphylococcus_aureus -LRB- hVISA -RRB- on vancomycin activity and emergence of VISA in an in vitro pharmacodynamic model .
11062261	0	hVPS45	54,60	Rabenosyn-5	0,11	hVPS45	Rabenosyn-5	11311	64145	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubjpass|END_ENTITY	Rabenosyn-5 , a novel Rab5 effector , is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain .
18957027	0	hVps15	0,6	hVps34	73,79	hVps15	hVps34	30849	5289	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activity activity|nmod|END_ENTITY	hVps15 , but not Ca2 + / CaM , is required for the activity and regulation of hVps34 in mammalian cells .
20634405	0	hVps34	157,163	beclin_1	148,156	hVps34	beclin 1	5289	8678	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	The epidermal_growth_factor_receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin_1 / hVps34 complex .
18957027	0	hVps34	73,79	hVps15	0,6	hVps34	hVps15	5289	30849	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	hVps15 , but not Ca2 + / CaM , is required for the activity and regulation of hVps34 in mammalian cells .
18460336	0	hVps34	62,68	mTOR	21,25	hVps34	mTOR	5289	21977(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Amino_acids activate mTOR complex 1 via Ca2 + / CaM signaling to hVps34 .
11813207	0	hXBP-1	50,56	X-box_binding_protein_1	25,48	hXBP-1	X-box binding protein 1	7494	7494	Gene	Gene	Down-regulation|dep|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of human X-box_binding_protein_1 -LRB- hXBP-1 -RRB- expression correlates with tumor progression in human prostate_cancers .
19802870	0	hZIP1	65,70	Ras_responsive_element_binding_protein-1	0,40	hZIP1	Ras responsive element binding protein-1	27173	6239	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Ras_responsive_element_binding_protein-1 -LRB- RREB-1 -RRB- down-regulates hZIP1 expression in prostate_cancer cells .
15932518	0	haem-oxygenase-1	23,39	HO-1	41,45	haem-oxygenase-1	HO-1	3162	3162	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of intestinal haem-oxygenase-1 -LRB- HO-1 -RRB- in clinical and experimental colitis .
9851535	0	haem_oxygenase	36,50	Nitric_oxide_synthase	0,21	haem oxygenase	Nitric oxide synthase	15368(Tax:10090)	18126(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Nitric_oxide_synthase inhibition by haem_oxygenase decreases macrophage nitric-oxide-dependent cytotoxicity : a negative feedback mechanism for the regulation of nitric_oxide production .
12002745	0	haematopoietic_prostaglandin_D_synthase	21,60	prostanoid_DP_receptor	71,93	haematopoietic prostaglandin D synthase	prostanoid DP receptor	27306	5729	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	New polymorphisms of haematopoietic_prostaglandin_D_synthase and human prostanoid_DP_receptor genes .
20080498	0	hairless	90,98	Hr	105,107	hairless	Hr	15460(Tax:10090)	15460(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular basis for hair loss in mice carrying a novel nonsense mutation -LRB- Hrrh-R -RRB- in the hairless gene -LRB- Hr -RRB- .
8354270	0	hairy	108,113	HES-2	30,35	hairy	HES-2	38995(Tax:7227)	54626	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Molecular characterization of HES-2 , a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split .
16119455	0	hampin	88,94	MSL-1	124,129	hampin	MSL-1	74026(Tax:10090)	35121(Tax:7227)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	-LSB- Tissue specificity of alternative splicing products of mouse mRNA encoding new protein hampin homologous to the Drosophila MSL-1 protein -RSB- .
1717278	0	haptoglobin	70,81	C-reactive_protein	29,47	haptoglobin	C-reactive protein	3240	1401	Gene	Gene	START_ENTITY|nsubj|levels levels|nmod|END_ENTITY	Pretreatment serum levels of C-reactive_protein , alpha 1-antitrypsin , haptoglobin , alpha 1-acid glycoprotein and tissue polypeptide antigen in cervical_carcinoma .
9127741	1	haptoglobin	119,130	CD22	152,156	haptoglobin	CD22	3240	933	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of haptoglobin to the B-cell lectin CD22 .
26901066	0	haptoglobin	36,47	HP	32,34	haptoglobin	HP	3240	3240	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Recurring exon deletions in the HP -LRB- haptoglobin -RRB- gene contribute to lower blood cholesterol levels .
22707233	0	haptoglobin	105,116	Haptoglobin	0,11	haptoglobin	Haptoglobin	24464(Tax:10116)	24464(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Haptoglobin and the inflammatory and oxidative status in experimental diabetic rats : antioxidant role of haptoglobin .
21224490	0	haptoglobin	41,52	Hypoxia-inducible_factor-1alpha	0,31	haptoglobin	Hypoxia-inducible factor-1alpha	3240	3091	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Hypoxia-inducible_factor-1alpha enhances haptoglobin gene expression by improving binding of STAT3 to the promoter .
8195587	0	haptoglobin	17,28	IL-6	150,154	haptoglobin	IL-6	3240	3569	Gene	Gene	expression|compound|START_ENTITY Determination|nmod|expression treated|nsubj|Determination treated|nmod|END_ENTITY	Determination of haptoglobin expression in IL-6 treated HepG2 cells by ELISA and by RNA hybridization -- evaluation of a quantitative method to measure IL-6 .
8195587	0	haptoglobin	17,28	IL-6	43,47	haptoglobin	IL-6	3240	3569	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Determination of haptoglobin expression in IL-6 treated HepG2 cells by ELISA and by RNA hybridization -- evaluation of a quantitative method to measure IL-6 .
11397854	0	haptoglobin	40,51	Interleukin-6	0,13	haptoglobin	Interleukin-6	3240	3569	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-6 differentially stimulates haptoglobin production by peritoneal and endometriotic cells in vitro : a model for endometrial-peritoneal interaction in endometriosis .
10364455	0	haptoglobin	15,26	TGFbeta	46,53	haptoglobin	TGFbeta	24464(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Attenuation of haptoglobin gene expression by TGFbeta requires the MAP kinase pathway .
2896626	0	haptoglobin	63,74	Tyrosine_aminotransferase	0,25	haptoglobin	Tyrosine aminotransferase	3240	6898	Gene	Gene	linked|xcomp|START_ENTITY linked|nsubjpass|END_ENTITY	Tyrosine_aminotransferase and chymotrypsinogen_B are linked to haptoglobin on human chromosome 16q : comparison of genetic and physical distances .
74964	1	haptoglobin	74,85	alpha-2-macroglobulin	108,129	haptoglobin	alpha-2-macroglobulin	3240	2	Gene	Gene	-RSB-|appos|START_ENTITY -RSB-|amod|END_ENTITY	Immunoglobulins A , G , M , haptoglobin , alpha-1-antitrypsin , alpha-2-macroglobulin -RSB- .
2073325	0	haptoglobin	56,67	alpha-chain	88,99	haptoglobin	alpha-chain	3240	2217	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Hemoglobin binding with haptoglobin : delineation of the haptoglobin binding site on the alpha-chain of human hemoglobin .
18783334	0	haptoglobin	120,131	apolipoprotein_A-I	84,102	haptoglobin	apolipoprotein A-I	3240	335	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Relevance of the amino_acid conversions L144R -LRB- Zaragoza -RRB- and L159P -LRB- Zavalla -RRB- in the apolipoprotein_A-I binding site for haptoglobin .
7116206	0	haptoglobin	35,46	cathepsin_L	14,25	haptoglobin	cathepsin L	24464(Tax:10116)	25697(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cathepsin_L and B by haptoglobin , the haptoglobin-hemoglobin complex , and asialohaptoglobin .
7586584	0	haptoglobin	45,56	fibrinogen	82,92	haptoglobin	fibrinogen	3240	2244	Gene	Gene	variation|nmod|START_ENTITY Components|nmod|variation Components|dep|relationships relationships|nmod|END_ENTITY	Components of biological variation in plasma haptoglobin : relationships to plasma fibrinogen and immune variables , including interleukin-6 and its receptor .
16453892	0	haptoglobin	10,21	interleukin-6	118,131	haptoglobin	interleukin-6	3240	3569	Gene	Gene	promoter|compound|START_ENTITY promoter|dep|elements elements|acl|interact interact|nmod|protein protein|acl|induced induced|advcl|END_ENTITY	The human haptoglobin gene promoter : interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6 .
2320005	0	haptoglobin	121,132	interleukin-6	58,71	haptoglobin	interleukin-6	24464(Tax:10116)	24498(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY element|nmod|gene element|amod|END_ENTITY	Structure , hormonal regulation , and identification of the interleukin-6 - and dexamethasone-responsive element of the rat haptoglobin gene .
23701120	0	haptoglobin	29,40	interleukin-6	107,120	haptoglobin	interleukin-6	3240	3569	Gene	Gene	Identification|nmod|START_ENTITY C-terminal|nsubj|Identification C-terminal|nmod|expression expression|amod|END_ENTITY	Identification of a specific haptoglobin C-terminal fragment in arthritic synovial fluid and its effect on interleukin-6 expression .
2787245	0	haptoglobin	10,21	interleukin-6	118,131	haptoglobin	interleukin-6	3240	3569	Gene	Gene	promoter|compound|START_ENTITY promoter|dep|elements elements|acl|interact interact|nmod|protein protein|acl|induced induced|advcl|END_ENTITY	The human haptoglobin gene promoter : interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6 .
7492636	0	haptoglobin	15,26	interleukin-6	40,53	haptoglobin	interleukin-6	280692(Tax:9913)	280826(Tax:9913)	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|amod|synthesis synthesis|nmod|END_ENTITY	Stimulation of haptoglobin synthesis by interleukin-6 and tumor_necrosis_factor , but not by interleukin-1 , in bovine primary cultured hepatocytes .
7586584	0	haptoglobin	45,56	interleukin-6	125,138	haptoglobin	interleukin-6	3240	3569	Gene	Gene	variation|nmod|START_ENTITY Components|nmod|variation Components|dep|relationships relationships|nmod|END_ENTITY	Components of biological variation in plasma haptoglobin : relationships to plasma fibrinogen and immune variables , including interleukin-6 and its receptor .
8387722	0	haptoglobin	62,73	interleukin-6	154,167	haptoglobin	interleukin-6	3240	3569	Gene	Gene	phenotype|amod|START_ENTITY associated|nmod|phenotype promoter|acl|associated substitution|nmod|promoter decreases|nsubj|substitution decreases|nmod|cells cells|amod|END_ENTITY	A base substitution in the promoter associated with the human haptoglobin 2-1 modified phenotype decreases transcriptional activity and responsiveness to interleukin-6 in human hepatoma cells .
3756181	0	haptoglobin	6,17	myoglobin	33,42	haptoglobin	myoglobin	3240	4151	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human haptoglobin binds to human myoglobin .
2876426	0	haptoglobin-related	79,98	Hpr	100,103	haptoglobin-related	Hpr	3250	3250	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Polymorphisms in the human haptoglobin gene cluster : chromosomes with multiple haptoglobin-related -LRB- Hpr -RRB- genes .
22981232	0	hbs1	15,19	dom34	9,14	hbs1	dom34	853959(Tax:4932)	855731(Tax:4932)	Gene	Gene	Roles|dep|START_ENTITY Roles|nmod|END_ENTITY	Roles of dom34 : hbs1 in nonstop protein clearance from translocators for normal organelle protein influx .
10388555	0	hck	150,153	NEF	94,97	hck	NEF	15162(Tax:10090)	156110(Tax:11676)	Gene	Gene	requires|dobj|START_ENTITY response|acl:relcl|requires response|nsubj|Induction Induction|nmod|macrophages macrophages|nmod|END_ENTITY	Induction of activator protein 1 -LRB- AP-1 -RRB- in macrophages by human_immunodeficiency_virus_type-1 NEF is a cell-type-specific response that requires both hck and MAPK signaling events .
11696983	0	hdc	88,91	headcase	78,86	hdc	headcase	43604(Tax:7227)	43604(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Isolation and characterization of the human gene homologous to the Drosophila headcase -LRB- hdc -RRB- gene in chromosome bands 6q23-q24 , a region of common deletion in human pancreatic_cancer .
17018602	0	hdm2	14,18	p53	102,105	hdm2	p53	4193	7157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|correlating correlating|nmod|stability stability|compound|END_ENTITY	Regulation of hdm2 by stress-induced hdm2alt1 in tumor and nontumorigenic cell lines correlating with p53 stability .
9430646	0	hdm2	36,40	p53	81,84	hdm2	p53	4193	7157	Gene	Gene	oncoprotein|amod|START_ENTITY shuttling|nmod|oncoprotein regulates|nsubj|shuttling regulates|dobj|levels levels|nmod|protein protein|compound|END_ENTITY	Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human_immunodeficiency_virus rev protein .
11696983	0	headcase	78,86	hdc	88,91	headcase	hdc	43604(Tax:7227)	43604(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Isolation and characterization of the human gene homologous to the Drosophila headcase -LRB- hdc -RRB- gene in chromosome bands 6q23-q24 , a region of common deletion in human pancreatic_cancer .
12128222	0	heart_LIM_protein	4,21	Hlp	28,31	heart LIM protein	Hlp	68337(Tax:10090)	68337(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The heart_LIM_protein gene -LRB- Hlp -RRB- , expressed in the developing and adult heart , defines a new tissue-specific LIM-only protein family .
23036802	0	heart_and_neural_crest_derivatives_expressed_transcript_2	18,75	fibulin-1	95,104	heart and neural crest derivatives expressed transcript 2	fibulin-1	9464	2192	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	Progestin-induced heart_and_neural_crest_derivatives_expressed_transcript_2 is associated with fibulin-1 expression in human endometrial stromal cells .
22042860	0	heat-shock_factor_1	23,42	HSF1	44,48	heat-shock factor 1	HSF1	3297	3297	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	High levels of nuclear heat-shock_factor_1 -LRB- HSF1 -RRB- are associated with poor prognosis in breast_cancer .
16050811	0	heat-shock_factor_1	56,75	Heat-shock_cognate_70	0,21	heat-shock factor 1	Heat-shock cognate 70	3297	3312	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Heat-shock_cognate_70 is required for the activation of heat-shock_factor_1 in mammalian cells .
8141767	0	heat-shock_protein	35,53	HSP70	55,60	heat-shock protein	HSP70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation of a novel inducible rat heat-shock_protein -LRB- HSP70 -RRB- gene and its expression during ischaemia/hypoxia and heat_shock .
9142686	0	heat-shock_protein	71,89	HSP70	91,96	heat-shock protein	HSP70	3308	3308	Gene	Gene	level|compound|START_ENTITY level|appos|END_ENTITY	Helium-neon laser irradiation is not a stressful treatment : a study on heat-shock_protein -LRB- HSP70 -RRB- level .
11196683	0	heat-shock_protein	52,70	HSP70-2	72,79	heat-shock protein	HSP70-2	3306	3306	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between the polymorphism at the heat-shock_protein -LRB- HSP70-2 -RRB- gene and systemic_lupus_erythematosus -LRB- SLE -RRB- in the Mexican mestizo population .
9191105	0	heat-shock_protein	13,31	HSP72	33,38	heat-shock protein	HSP72	24472(Tax:10116)	24472(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of heat-shock_protein -LRB- HSP72 -RRB- in the cingulate and retrosplenial cortex by drugs that antagonize the effects of excitatory amino_acids .
7859920	0	heat-shock_protein	14,32	hsp70	34,39	heat-shock protein	hsp70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of heat-shock_protein -LRB- hsp70 -RRB- gene expression by hGH and IL2 in rat Nb2 lymphoma cells .
15884019	0	heat-shock_protein	58,76	neuroblastoma	91,104	heat-shock protein	neuroblastoma	15511(Tax:10090)	230972(Tax:10090)	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	Hypoglycemia enhances the expression of prion_protein and heat-shock_protein 70 in a mouse neuroblastoma cell line .
12226095	0	heat-shock_protein_27	14,35	Hsp27	37,42	heat-shock protein 27	Hsp27	3315	3315	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Modulation of heat-shock_protein_27 -LRB- Hsp27 -RRB- anti-apoptotic activity by methylglyoxal modification .
11034403	0	heat-shock_protein_27	79,100	TNF-alpha	56,65	heat-shock protein 27	TNF-alpha	3315	7124	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock_protein_27 -LRB- Hsp27 -RRB- suggests Hsp27 is primarily an antiinflammatory stimulus .
8526844	0	heat-shock_protein_27	64,85	hsp27	87,92	heat-shock protein 27	hsp27	3315	3315	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Intracellular reactive oxygen species as apparent modulators of heat-shock_protein_27 -LRB- hsp27 -RRB- structural organization and phosphorylation in basal and tumour_necrosis factor alpha-treated T47D human carcinoma cells .
8833636	0	heat-shock_protein_70	19,40	HSP70	42,47	heat-shock protein 70	HSP70	3308	3308	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated levels of heat-shock_protein_70 -LRB- HSP70 -RRB- in the mononuclear cells of patients with non-insulin-dependent diabetes_mellitus .
15576310	0	heat-shock_protein_70	22,43	Hsp70	45,50	heat-shock protein 70	Hsp70	3308	3308	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Exercise raises serum heat-shock_protein_70 -LRB- Hsp70 -RRB- levels .
22859491	0	heat-shock_protein_90	45,66	vascular_endothelial_growth_factor	109,143	heat-shock protein 90	vascular endothelial growth factor	104434(Tax:10090)	22339(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Modulation of the cochaperone AHA1 regulates heat-shock_protein_90 and endothelial NO synthase activation by vascular_endothelial_growth_factor .
25043441	0	heat-shock_protein_A2	14,35	HSPA2	37,42	heat-shock protein A2	HSPA2	60460(Tax:10116)	60460(Tax:10116)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of heat-shock_protein_A2 -LRB- HSPA2 -RRB- in male rats before and after varicocele induction .
26598328	0	heat-shock_protein_A9	17,38	HSPA9	40,45	heat-shock protein A9	HSPA9	3313	3313	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the heat-shock_protein_A9 -LRB- HSPA9 -RRB- gene cause the EVEN-PLUS_syndrome of congenital_malformations and skeletal_dysplasia .
23055712	0	heat-shock_protein_aB-crystalline	18,51	HspB5	53,58	heat-shock protein aB-crystalline	HspB5	1410	1410	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of small heat-shock_protein_aB-crystalline -LRB- HspB5 -RRB- in COPD pathogenesis .
11136617	0	heat-shock_transcription_factor	56,87	HSF	89,92	heat-shock transcription factor	HSF	37068(Tax:7227)	37068(Tax:7227)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Laboratory selection at different temperatures modifies heat-shock_transcription_factor -LRB- HSF -RRB- activation in Drosophila_melanogaster .
8761470	0	heat-shock_transcription_factor	19,50	HSF	52,55	heat-shock transcription factor	HSF	3569	3569	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Dual regulation of heat-shock_transcription_factor -LRB- HSF -RRB- activation and DNA-binding activity by H2O2 : role of thioredoxin .
10816597	0	heat-shock_transcription_factor_1	91,124	P-glycoprotein	44,58	heat-shock transcription factor 1	P-glycoprotein	3297	5243	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of multidrug_resistance_1 -LRB- MDR1 -RRB- / P-glycoprotein gene expression and activity by heat-shock_transcription_factor_1 -LRB- HSF1 -RRB- .
10816597	0	heat-shock_transcription_factor_1	91,124	multidrug_resistance_1	14,36	heat-shock transcription factor 1	multidrug resistance 1	3297	5243	Gene	Gene	expression|nmod|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of multidrug_resistance_1 -LRB- MDR1 -RRB- / P-glycoprotein gene expression and activity by heat-shock_transcription_factor_1 -LRB- HSF1 -RRB- .
14715258	0	heat_shock_27kDa_protein	16,40	Stat3	0,5	heat shock 27kDa protein	Stat3	3315	6774	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Stat3 modulates heat_shock_27kDa_protein expression in breast epithelial cells .
10653585	0	heat_shock_chaperonin_protein	36,65	Hsp60	67,72	heat shock chaperonin protein	Hsp60	3329	3329	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of mitochondrial 60-kD heat_shock_chaperonin_protein -LRB- Hsp60 -RRB- in pituitary growth_hormone secretory granules and pancreatic zymogen granules .
9243807	0	heat_shock_chaperonin_protein	40,69	hsp60	71,76	heat shock chaperonin protein	hsp60	3329	3329	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cell surface localization of the 60 kDa heat_shock_chaperonin_protein -LRB- hsp60 -RRB- in mammalian cells .
9219918	0	heat_shock_estrogen_receptor-associated_protein	53,100	Hsp27	47,52	heat shock estrogen receptor-associated protein	Hsp27	3315	3315	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Lack of relationship between the expression of Hsp27 heat_shock_estrogen_receptor-associated_protein and estrogen receptor or progesterone receptor status in male_breast_carcinoma .
15618017	0	heat_shock_factor-1	21,40	heme_oxygenase-1	71,87	heat shock factor-1	heme oxygenase-1	3297	3162	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|END_ENTITY	The possible role of heat_shock_factor-1 in the negative regulation of heme_oxygenase-1 .
16365894	0	heat_shock_factor-2	26,45	RANK_ligand	0,11	heat shock factor-2	RANK ligand	15500(Tax:10090)	21943(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	RANK_ligand expression in heat_shock_factor-2 deficient mouse bone marrow stromal/preosteoblast cells .
15016915	0	heat_shock_factor_1	20,39	DAXX	0,4	heat shock factor 1	DAXX	3297	1616	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	DAXX interacts with heat_shock_factor_1 during stress activation and enhances its transcriptional activity .
17102673	0	heat_shock_protein	45,63	HSP27	65,70	heat shock protein	HSP27	3315	3315	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	UVB irradiation-induced changes in the 27-kd heat_shock_protein -LRB- HSP27 -RRB- in human corneal epithelial cells .
20806039	0	heat_shock_protein	14,32	HSP60	34,39	heat shock protein	HSP60	3329	3329	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Assessment of heat_shock_protein -LRB- HSP60 , HSP72 , HSP90 , and HSC70 -RRB- expression in cultured limbal stem cells following air lifting .
9649220	0	heat_shock_protein	36,54	hsp	56,59	heat shock protein	hsp	7190	7190	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Circulating antibodies to the 60-kD heat_shock_protein -LRB- hsp -RRB- family in patients with Helicobacter_pylori_infection .
16861019	0	heat_shock_protein	37,55	hsp110	62,68	heat shock protein	hsp110	398343(Tax:8355)	446527(Tax:8355)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Examination of the expression of the heat_shock_protein gene , hsp110 , in Xenopus_laevis cultured cells and embryos .
21605158	0	heat_shock_protein	45,63	myeloperoxidase	81,96	heat shock protein	myeloperoxidase	7190	4353	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Increased concentrations of antibody against heat_shock_protein in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody positive microscopic_polyangiitis .
22324999	0	heat_shock_protein-47	46,67	elastin	69,76	heat shock protein-47	elastin	871	2006	Gene	Gene	components|amod|START_ENTITY components|amod|END_ENTITY	Beneficial regulation of fibrillar collagens , heat_shock_protein-47 , elastin fiber components , transforming_growth_factor-b1 , vascular_endothelial_growth_factor and oxidative stress effects by copper in dermal fibroblasts .
17406896	0	heat_shock_protein-70	21,42	Leptin	0,6	heat shock protein-70	Leptin	423504(Tax:9031)	373955(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Leptin downregulates heat_shock_protein-70 -LRB- HSP-70 -RRB- gene expression in chicken liver and hypothalamus .
22461698	0	heat_shock_protein-70	14,35	TLR4	57,61	heat shock protein-70	TLR4	15511(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Intracellular heat_shock_protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium .
23874968	0	heat_shock_protein-70	24,45	hsp72	47,52	heat shock protein-70	hsp72	3303	3303	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of inducible heat_shock_protein-70 -LRB- hsp72 -RRB- enhances bortezomib-induced cell death in human bladder_cancer cells .
22139844	0	heat_shock_protein_20	18,39	HSP20	41,46	heat shock protein 20	HSP20	126393	126393	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role for heat_shock_protein_20 -LRB- HSP20 -RRB- in migration of malarial sporozoites .
19322656	0	heat_shock_protein_27	33,54	Hsp27	56,61	heat shock protein 27	Hsp27	3315	3315	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of small heat_shock_protein_27 -LRB- Hsp27 -RRB- in Ataxia_telangiectasia brains .
23594402	0	heat_shock_protein_32	80,101	Nucleolin	0,9	heat shock protein 32	Nucleolin	24451(Tax:10116)	25135(Tax:10116)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Nucleolin protects the heart from ischaemia-reperfusion injury by up-regulating heat_shock_protein_32 .
17588138	0	heat_shock_protein_60	14,35	Hsp60	37,42	heat shock protein 60	Hsp60	3329	3329	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Extracellular heat_shock_protein_60 -LRB- Hsp60 -RRB- levels in children with septic_shock .
18950664	0	heat_shock_protein_65	104,125	hsp65	127,132	heat shock protein 65	hsp65	3329	3329	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparative evaluation of Polymerase Chain Reaction-Restriction Enzyme Analysis -LRB- PRA -RRB- and sequencing of heat_shock_protein_65 -LRB- hsp65 -RRB- gene for identification of aquatic mycobacteria .
24923353	0	heat_shock_protein_70	17,38	14-3-3	0,6	heat shock protein 70	14-3-3	3308	10971	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	14-3-3 induces heat_shock_protein_70 expression in hepatocellular_carcinoma .
12653481	0	heat_shock_protein_70	88,109	CD94	137,141	heat shock protein 70	CD94	15511(Tax:10090)	16643(Tax:10090)	Gene	Gene	START_ENTITY|dep|cells cells|amod|END_ENTITY	Inhibition of tumor growth in mice with severe combined immunodeficiency is mediated by heat_shock_protein_70 -LRB- Hsp70 -RRB- - peptide-activated , CD94 positive natural killer cells .
10638664	0	heat_shock_protein_70	43,64	HSP-70	66,72	heat shock protein 70	HSP-70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cecal ligation and double puncture impairs heat_shock_protein_70 -LRB- HSP-70 -RRB- expression in the lungs of rats .
10051078	0	heat_shock_protein_70	19,40	HSP70	42,47	heat shock protein 70	HSP70	3308	3308	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Endotoxin inhibits heat_shock_protein_70 -LRB- HSP70 -RRB- expression in peripheral blood mononuclear cells of patients with severe sepsis .
11566631	0	heat_shock_protein_70	166,187	HSP70	189,194	heat shock protein 70	HSP70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Strain-dependent difference in inducible nitric_oxide synthesis -LRB- iNOS -RRB- expression in rat pancreatic islets correlates with interferon_regulating_factor_1 -LRB- IRF-1 -RRB- and heat_shock_protein_70 -LRB- HSP70 -RRB- expression .
21345207	0	heat_shock_protein_70	27,48	HSP70	50,55	heat shock protein 70	HSP70	3308	3308	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of heat_shock_protein_70 -LRB- HSP70 -RRB- in patients with oral_cancer .
16309579	0	heat_shock_protein_70	57,78	HSP_70	80,86	heat shock protein 70	HSP 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II type I antagonist on oxidative stress and heat_shock_protein_70 -LRB- HSP_70 -RRB- expression in obstructive nephropathy .
12489113	0	heat_shock_protein_70	11,32	Hsp70	34,39	heat shock protein 70	Hsp70	3308	3308	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of heat_shock_protein_70 -LRB- Hsp70 -RRB- on arsenite-induced genotoxicity .
12530536	0	heat_shock_protein_70	67,88	Hsp70	90,95	heat shock protein 70	Hsp70	3308	3308	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Effects of antineoplastic agents on cytoplasmic and membrane-bound heat_shock_protein_70 -LRB- Hsp70 -RRB- levels .
18347936	0	heat_shock_protein_70	64,85	Hsp70	87,92	heat shock protein 70	Hsp70	3308	3308	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The therapeutic implications of clinically applied modifiers of heat_shock_protein_70 -LRB- Hsp70 -RRB- expression by tumor cells .
20734248	0	heat_shock_protein_70	44,65	Hsp70	67,72	heat shock protein 70	Hsp70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	The Nrf2-Keap1 cellular defense pathway and heat_shock_protein_70 -LRB- Hsp70 -RRB- response .
22322648	0	heat_shock_protein_70	89,110	Hsp70	112,117	heat shock protein 70	Hsp70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tonicity_enhancer_binding_protein -LRB- TonEBP -RRB- and hypoxia-inducible factor -LRB- HIF -RRB- coordinate heat_shock_protein_70 -LRB- Hsp70 -RRB- expression in hypoxic nucleus pulposus cells : role of Hsp70 in HIF-1a degradation .
22322648	0	heat_shock_protein_70	89,110	Hsp70	173,178	heat shock protein 70	Hsp70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Tonicity_enhancer_binding_protein -LRB- TonEBP -RRB- and hypoxia-inducible factor -LRB- HIF -RRB- coordinate heat_shock_protein_70 -LRB- Hsp70 -RRB- expression in hypoxic nucleus pulposus cells : role of Hsp70 in HIF-1a degradation .
22933182	0	heat_shock_protein_70	104,125	Hsp70	127,132	heat shock protein 70	Hsp70	3308	3308	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat_shock_protein_70 -LRB- Hsp70 -RRB- levels .
24890362	0	heat_shock_protein_70	25,46	Hsp70	48,53	heat shock protein 70	Hsp70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The protective effect of heat_shock_protein_70 -LRB- Hsp70 -RRB- in atrial_fibrillation in various cardiomyopathy conditions .
25681671	0	heat_shock_protein_70	12,33	Hsp70	35,40	heat shock protein 70	Hsp70	3308	3308	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of heat_shock_protein_70 -LRB- Hsp70 -RRB- in radiation-induced immunomodulation .
16142794	0	heat_shock_protein_70	22,43	Hsp_70	45,51	heat shock protein 70	Hsp 70	3308	3308	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of heat_shock_protein_70 -LRB- Hsp_70 -RRB- in boar spermatozoa and its role during fertilization .
18613644	0	heat_shock_protein_70	40,61	NKG2D	83,88	heat shock protein 70	NKG2D	3308	22914	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Activation of NK cells by extracellular heat_shock_protein_70 through induction of NKG2D ligands on dendritic cells .
18197143	0	heat_shock_protein_70	13,34	YC-1	0,4	heat shock protein 70	YC-1	3308	5937	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	YC-1 induces heat_shock_protein_70 expression and prevents oxidized LDL-mediated apoptosis in vascular smooth muscle cells .
24708778	0	heat_shock_protein_70	75,96	hsp70	98,103	heat shock protein 70	hsp70	3308	3308	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Effect of multiple microsporidian infections and temperature stress on the heat_shock_protein_70 -LRB- hsp70 -RRB- response of the amphipod Gammarus pulex .
7788642	0	heat_shock_protein_70	46,67	hsp70	69,74	heat shock protein 70	hsp70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Selective postmortem degradation of inducible heat_shock_protein_70 -LRB- hsp70 -RRB- mRNAs in rat brain .
24532784	0	heat_shock_protein_70	7,28	insulin	38,45	heat shock protein 70	insulin	3308	3630	Gene	Gene	predicts|nsubj|START_ENTITY predicts|dobj|resistance resistance|compound|END_ENTITY	Muscle heat_shock_protein_70 predicts insulin resistance with aging .
25900241	0	heat_shock_protein_70	103,124	retinoic_acid_induced_16	50,74	heat shock protein 70	retinoic acid induced 16	3308	64760	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Anchoring of both PKA-RIIa and 14-3-3 regulates retinoic_acid_induced_16 mediated phosphorylation of heat_shock_protein_70 .
21896482	0	heat_shock_protein_70	18,39	tissue_transglutaminase	64,87	heat shock protein 70	tissue transglutaminase	3308	7052	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	A unique role for heat_shock_protein_70 and its binding partner tissue_transglutaminase in cancer cell migration .
22289917	0	heat_shock_protein_72	16,37	Hsp72	39,44	heat shock protein 72	Hsp72	3303	3303	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Consequences of heat_shock_protein_72 -LRB- Hsp72 -RRB- expression and activity on stress-induced apoptosis in CD30 + NPM-ALK + anaplastic_large-cell_lymphomas .
20444924	0	heat_shock_protein_90	9,30	HSP90	32,37	heat shock protein 90	HSP90	3320	3320	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	RET is a heat_shock_protein_90 -LRB- HSP90 -RRB- client protein and is knocked down upon HSP90 pharmacological block .
21219297	0	heat_shock_protein_90	14,35	HSP90	37,42	heat shock protein 90	HSP90	3320	3320	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of heat_shock_protein_90 -LRB- HSP90 -RRB- as a therapeutic strategy for the treatment of myeloma and other cancers .
24831003	0	heat_shock_protein_90	126,147	HSP90	149,154	heat shock protein 90	HSP90	3320	3320	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Identification of mixed_lineage_leukemia_1 -LRB- MLL1 -RRB- protein as a coactivator of heat_shock_factor_1 -LRB- HSF1 -RRB- protein in response to heat_shock_protein_90 -LRB- HSP90 -RRB- inhibition .
26581400	0	heat_shock_protein_90	34,55	Hsp90	56,61	heat shock protein 90	Hsp90	3320	3320	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	A phase II trial of ganetespib , a heat_shock_protein_90 Hsp90 -RRB- inhibitor , in patients with docetaxel-pretreated metastatic castrate-resistant prostate_cancer -LRB- CRPC -RRB- - a prostate_cancer clinical trials consortium -LRB- PCCTC -RRB- study .
15967841	0	heat_shock_protein_90	70,91	endothelial_nitric_oxide_synthase	19,52	heat shock protein 90	endothelial nitric oxide synthase	104434(Tax:10090)	18127(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	Estradiol-mediated endothelial_nitric_oxide_synthase association with heat_shock_protein_90 requires adenosine_monophosphate-dependent protein kinase .
12521608	0	heat_shock_protein_90	14,35	hsp90	37,42	heat shock protein 90	hsp90	3320	3320	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of heat_shock_protein_90 -LRB- hsp90 -RRB- in proliferating endothelial cells uncouples endothelial_nitric_oxide_synthase activity .
21430289	0	heat_shock_protein_90	19,40	iNOS	44,48	heat shock protein 90	iNOS	104434(Tax:10090)	18126(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|induction induction|amod|END_ENTITY	Obligatory role of heat_shock_protein_90 in iNOS induction .
19028451	0	heat_shock_protein_90	14,35	interleukin-8	44,57	heat shock protein 90	interleukin-8	3320	3576	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Extracellular heat_shock_protein_90 induces interleukin-8 in vascular smooth muscle cells .
25437815	0	heat_shock_protein_a4	15,36	apg-2	37,42	heat shock protein a4	apg-2	3308	3308	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of heat_shock_protein_a4 / apg-2 in refractory inflammatory_bowel_disease .
12603322	0	heat_shock_protein_with_molecular_mass_25_kDa	25,70	hsp25	72,77	heat shock protein with molecular mass 25 kDa	hsp25	3315	3315	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the small heat_shock_protein_with_molecular_mass_25_kDa -LRB- hsp25 -RRB- with actin .
8226859	0	heat_stable_antigen	4,23	CD24	31,35	heat stable antigen	CD24	12484(Tax:10090)	12484(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The heat_stable_antigen -LRB- mouse CD24 -RRB- gene is differentially regulated but has a housekeeping promoter .
25552605	0	hecd-1	0,6	Notch	17,22	hecd-1	Notch	177486(Tax:6239)	176282(Tax:6239)	Gene	Gene	Modulates|amod|START_ENTITY END_ENTITY|nsubj|Modulates	hecd-1 Modulates Notch Activity in Caenorhabditis_elegans .
9601642	0	hedgehog	63,71	Cubitus_interruptus	36,55	hedgehog	Cubitus interruptus	42737(Tax:7227)	43767(Tax:7227)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Suppressor of fused links fused and Cubitus_interruptus on the hedgehog signalling pathway .
9109493	0	hedgehog	59,67	cubitus_interruptus	36,55	hedgehog	cubitus interruptus	42737(Tax:7227)	43767(Tax:7227)	Gene	Gene	signalling|amod|START_ENTITY END_ENTITY|nmod|signalling	Drosophila CBP is a co-activator of cubitus_interruptus in hedgehog signalling .
12645926	0	hedgehog	95,103	sex-lethal	116,126	hedgehog	sex-lethal	42737(Tax:7227)	3772180(Tax:7227)	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|END_ENTITY	Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin_B .
8700230	0	hedgehog	67,75	smoothened	0,10	hedgehog	smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	required|advcl|START_ENTITY protein|acl|required encodes|dobj|protein encodes|nsubj|END_ENTITY	smoothened encodes a receptor-like serpentine protein required for hedgehog signalling .
8706127	0	hedgehog	98,106	smoothened	15,25	hedgehog	smoothened	42737(Tax:7227)	33196(Tax:7227)	Gene	Gene	signal|amod|START_ENTITY receptor|nmod|signal protein|appos|receptor encodes|dobj|protein encodes|nsubj|gene gene|amod|END_ENTITY	The Drosophila smoothened gene encodes a seven-pass membrane protein , a putative receptor for the hedgehog signal .
15754313	0	hedgehog-interacting_protein	26,54	Hip	56,59	hedgehog-interacting protein	Hip	64399	64399	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the human hedgehog-interacting_protein -LRB- Hip -RRB- in the normal and diseased pancreas .
11279182	0	helicase	96,104	AKAP95	27,33	helicase	AKAP95	164045	10270	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase .
19671661	0	helicase	4,12	ATPase	28,34	helicase	ATPase	164045	1769	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54 .
9840919	0	helicase	64,72	ATPase	49,55	helicase	ATPase	164045	1769	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Point mutations causing Bloom 's _ syndrome abolish ATPase and DNA helicase activities of the BLM protein .
20122406	0	helicase	25,33	Cdc45	54,59	helicase	Cdc45	33118(Tax:7227)	31052(Tax:7227)	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins .
12214280	0	helicase	35,43	HELAD1	13,19	helicase	HELAD1	164045	89797	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Isolation of HELAD1 , a novel human helicase gene up-regulated in colorectal_carcinomas .
24440721	0	helicase	35,43	Hrq1	0,4	helicase	Hrq1	164045	851885(Tax:4932)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Hrq1 , a homolog of the human RecQ4 helicase , acts catalytically and structurally to promote genome integrity .
20122406	0	helicase	25,33	MCM2-7	18,24	helicase	MCM2-7	33118(Tax:7227)	40973(Tax:7227)	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins .
15294075	0	helicase	55,63	NS3	51,54	helicase	NS3	164045	3845	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	In vitro selection of RNA aptamers against the HCV NS3 helicase domain .
15294075	3	helicase	315,323	NS3	311,314	helicase	NS3	164045	3845	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	To study RNA aptamers of the NS3 helicase domain , we carried out in vitro selection against the HCV NS3 helicase domain .
18039921	0	helicase	50,58	NS3	46,49	helicase	NS3	164045	3845	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	NS3 Peptide , a novel potent hepatitis_C virus NS3 helicase inhibitor : its mechanism of action and antiviral activity in the replicon system .
17827721	0	helicase	53,61	Pif1	48,52	helicase	Pif1	164045	80119	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Mitochondrial and nuclear localization of human Pif1 helicase .
20524933	0	helicase	11,19	Pif1	6,10	helicase	Pif1	164045	80119	Gene	Gene	protein|advmod|START_ENTITY protein|nsubj|END_ENTITY	Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity .
25471447	0	helicase	46,54	Pif1	111,115	helicase	Pif1	164045	80119	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|dep|sequential sequential|nmod|G-quadruplex G-quadruplex|nmod|helicase helicase|amod|END_ENTITY	Molecular mechanism of G-quadruplex unwinding helicase : sequential and repetitive unfolding of G-quadruplex by Pif1 helicase .
25062910	0	helicase	46,54	RNA_helicase_A	67,81	helicase	RNA helicase A	164045	1660	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Helicase associated 2 domain is essential for helicase activity of RNA_helicase_A .
20225160	0	helicase	43,51	Upf1	38,42	helicase	Upf1	164045	5976	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Biochemical characterization of human Upf1 helicase .
23275559	0	helicase	50,58	Upf1	45,49	helicase	Upf1	164045	5976	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Tight intramolecular regulation of the human Upf1 helicase by its N - and C-terminal domains .
15735006	0	helicase	52,60	WRN	48,51	helicase	WRN	164045	7486	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	p53 modulates RPA-dependent and RPA-independent WRN helicase activity .
21220316	0	helicase	14,22	WRN	86,89	helicase	WRN	164045	7486	Gene	Gene	activity|amod|START_ENTITY Inhibition|nmod|activity impairs|nsubj|Inhibition impairs|ccomp|function function|nsubj|Werner_syndrome_helicase Werner_syndrome_helicase|appos|END_ENTITY	Inhibition of helicase activity by a small molecule impairs Werner_syndrome_helicase -LRB- WRN -RRB- function in the cellular response to DNA damage or replication stress .
26808708	0	helicase	27,35	WRN	23,26	helicase	WRN	164045	7486	Gene	Gene	START_ENTITY|nsubj|inhibition inhibition|nmod|END_ENTITY	Targeted inhibition of WRN helicase by external guide sequence and RNase P RNA .
11418588	0	helicase	18,26	eIF4A	39,44	helicase	eIF4A	164045	1973	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Modulation of the helicase activity of eIF4A by eIF4B , eIF4H , and eIF4F .
15735006	0	helicase	52,60	p53	0,3	helicase	p53	164045	7157	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	p53 modulates RPA-dependent and RPA-independent WRN helicase activity .
23826137	0	helicase-like_transcription_factor	8,42	hltf	44,48	helicase-like transcription factor	hltf	20585(Tax:10090)	20585(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of helicase-like_transcription_factor -LRB- hltf -RRB- in the G2/m transition and apoptosis in brain .
24523019	0	helicase_1	33,43	RTEL1	45,50	helicase 1	RTEL1	56916	51750	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Regulator of telomere elongation helicase_1 -LRB- RTEL1 -RRB- rs6010620 polymorphism contribute to increased risk of glioma .
18689483	0	hemA	48,52	PrrA	61,65	hemA	PrrA	3720398(Tax:272943)	3718682(Tax:272943)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the Rhodobacter_sphaeroides_2 .4.1 hemA gene by PrrA and FnrL .
12610140	0	hemagglutinin-neuraminidase	68,95	HN	97,99	hemagglutinin-neuraminidase	HN	911961(Tax:11216)	911961(Tax:11216)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Triggering of human_parainfluenza_virus_3 fusion protein -LRB- F -RRB- by the hemagglutinin-neuraminidase -LRB- HN -RRB- protein : an HN mutation diminishes the rate of F activation and fusion .
2718627	0	hemagglutinin-neuraminidase	36,63	HN	65,67	hemagglutinin-neuraminidase	HN	1489765(Tax:11161)	1489765(Tax:11161)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Complete nucleotide sequence of the hemagglutinin-neuraminidase -LRB- HN -RRB- mRNA of mumps_virus_and_comparison_of_paramyxovirus_HN_proteins .
21993313	0	hematopoietic_cell_kinase	18,43	HCK	45,48	hematopoietic cell kinase	HCK	3055	3055	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the hematopoietic_cell_kinase -LRB- HCK -RRB- by PML/RARa and PU .1 in acute_promyelocytic_leukemia .
9822652	0	hematopoietic_cell_kinase	84,109	HCK	111,114	hematopoietic cell kinase	HCK	3055	3055	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The transcription factor Sp1 regulates the myeloid-specific expression of the human hematopoietic_cell_kinase -LRB- HCK -RRB- gene through binding to two adjacent GC boxes within the HCK promoter-proximal region .
11145649	0	hematopoietic_cell_phosphatase	16,46	Hcph	48,52	hematopoietic cell phosphatase	Hcph	15170(Tax:10090)	15170(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation of the hematopoietic_cell_phosphatase -LRB- Hcph -RRB- gene is associated with resistance to gamma-irradiation-induced apoptosis in Src_homology_protein_tyrosine_phosphatase -LRB- SHP -RRB- -1 - deficient `` motheaten '' mutant mice .
11001933	0	hematopoietic_cell_phosphatase	45,75	PTPN6	77,82	hematopoietic cell phosphatase	PTPN6	5777	5777	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	RNA hyperediting and alternative splicing of hematopoietic_cell_phosphatase -LRB- PTPN6 -RRB- gene in acute_myeloid_leukemia .
7629131	0	hematopoietic_cell_phosphatase	71,101	Tyk-2	56,61	hematopoietic cell phosphatase	Tyk-2	5777	7297	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Association of the interferon-dependent tyrosine kinase Tyk-2 with the hematopoietic_cell_phosphatase .
7684496	0	hematopoietic_cell_phosphatase	15,45	c-Kit	51,56	hematopoietic cell phosphatase	c-Kit	5777	3815	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of hematopoietic_cell_phosphatase with c-Kit after stimulation with c-Kit_ligand .
8324828	0	hematopoietic_cell_protein-tyrosine_phosphatase	55,102	Hcph	104,108	hematopoietic cell protein-tyrosine phosphatase	Hcph	15170(Tax:10090)	15170(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations at the murine motheaten locus are within the hematopoietic_cell_protein-tyrosine_phosphatase -LRB- Hcph -RRB- gene .
9278437	0	hematopoietic_progenitor_kinase-1	18,51	c-Jun_N-terminal_kinase	87,110	hematopoietic progenitor kinase-1	c-Jun N-terminal kinase	11184	5599	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of the hematopoietic_progenitor_kinase-1 -LRB- HPK1 -RRB- - dependent , stress-activated c-Jun_N-terminal_kinase -LRB- JNK -RRB- pathway by transforming_growth_factor_beta -LRB- TGF-beta -RRB- - activated kinase -LRB- TAK1 -RRB- , a kinase mediator of TGF_beta signal transduction .
10233887	0	hematopoietic_progenitor_kinase-1	14,47	erythropoietin	51,65	hematopoietic progenitor kinase-1	erythropoietin	11184	2056	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of hematopoietic_progenitor_kinase-1 by erythropoietin .
11313918	0	hematopoietic_progenitor_kinase_1	56,89	Grap2	35,40	hematopoietic progenitor kinase 1	Grap2	11184	9402	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic_progenitor_kinase_1 -LRB- HPK1 -RRB- to activate JNK signaling pathway in T lymphocytes .
22421156	0	hematopoietic_progenitor_kinase_1	13,46	HPK1	48,52	hematopoietic progenitor kinase 1	HPK1	11184	11184	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Dual role of hematopoietic_progenitor_kinase_1 -LRB- HPK1 -RRB- as a positive regulator of 1a,25-dihydroxyvitamin _ D-induced differentiation and cell cycle arrest of AML cells and as a mediator of vitamin_D resistance .
15364934	0	hematopoietic_progenitor_kinase_1	49,82	phosphatase_4	8,21	hematopoietic progenitor kinase 1	phosphatase 4	11184	5531	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Protein phosphatase_4 is a positive regulator of hematopoietic_progenitor_kinase_1 .
16226275	0	hematopoietic_tyrosine_phosphatase	17,51	HePTP	53,58	hematopoietic tyrosine phosphatase	HePTP	5778	5778	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Structure of the hematopoietic_tyrosine_phosphatase -LRB- HePTP -RRB- catalytic domain : structure of a KIM phosphatase with phosphate bound at the active site .
8031836	0	heme	24,28	hemopexin	40,49	heme	hemopexin	100307951(Tax:9913)	100009541(Tax:9986)	Gene	Gene	complex|amod|START_ENTITY complex|nmod|END_ENTITY	Proton NMR study of the heme complex of hemopexin .
23139759	0	heme-oxygenase-1	15,31	HO-1	33,37	heme-oxygenase-1	HO-1	3162	3162	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Maternal serum heme-oxygenase-1 -LRB- HO-1 -RRB- concentrations in early pregnancy and subsequent risk of gestational_diabetes_mellitus .
17761498	0	heme-regulated_inhibitor	164,188	eIF2alpha	142,151	heme-regulated inhibitor	eIF2alpha	27137(Tax:10116)	502531(Tax:10116)	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Impaired dexamethasone-mediated induction of tryptophan_2 ,3 - dioxygenase in heme-deficient rat hepatocytes : translational control by a hepatic eIF2alpha kinase , the heme-regulated_inhibitor .
12835107	0	heme_oxygenase	23,37	HO-1	79,83	heme oxygenase	HO-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|parataxis|END_ENTITY	Induction of inducible heme_oxygenase -LRB- HO-1 -RRB- in the central nervous system : is HO-1 helpful or harmful ?
23525626	0	heme_oxygenase-1	86,102	AMP-activated_protein_kinase	107,135	heme oxygenase-1	AMP-activated protein kinase	3162	5563	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	b-Lapachone , a substrate of NAD -LRB- P -RRB- H : quinone oxidoreductase , induces anti-inflammatory heme_oxygenase-1 via AMP-activated_protein_kinase activation in RAW264 .7 macrophages .
22147269	0	heme_oxygenase-1	16,32	Akt	68,71	heme oxygenase-1	Akt	24451(Tax:10116)	24185(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|parataxis|confer confer|nsubj|END_ENTITY	Upregulation of heme_oxygenase-1 by acteoside through ERK and PI3_K / Akt pathway confer neuroprotection against beta-amyloid-induced neurotoxicity .
15465821	0	heme_oxygenase-1	32,48	Bach-1	8,14	heme oxygenase-1	Bach-1	3162	571	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Role of Bach-1 in regulation of heme_oxygenase-1 in human liver cells : insights from studies with small interfering RNAS .
12356737	0	heme_oxygenase-1	53,69	Bach1	12,17	heme oxygenase-1	Bach1	15368(Tax:10090)	12013(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY availability|nmod|gene regulates|dobj|availability regulates|nsubj|END_ENTITY	Hemoprotein Bach1 regulates enhancer availability of heme_oxygenase-1 gene .
12511571	0	heme_oxygenase-1	57,73	Bach1	0,5	heme oxygenase-1	Bach1	3162	571	Gene	Gene	gene|amod|START_ENTITY functions|nmod|gene functions|amod|END_ENTITY	Bach1 functions as a hypoxia-inducible repressor for the heme_oxygenase-1 gene in human cells .
17065227	0	heme_oxygenase-1	47,63	Bach1	8,13	heme oxygenase-1	Bach1	3162	571	Gene	Gene	gene|amod|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of Bach1 and Nrf2 in up-regulation of the heme_oxygenase-1 gene by cobalt_protoporphyrin .
18948842	0	heme_oxygenase-1	16,32	Bach1	0,5	heme oxygenase-1	Bach1	15368(Tax:10090)	12013(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Bach1 modulates heme_oxygenase-1 expression in the neonatal mouse lung .
20345481	0	heme_oxygenase-1	14,30	Bach1	103,108	heme oxygenase-1	Bach1	3162	571	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of heme_oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1 .
22698995	0	heme_oxygenase-1	28,44	Bach1	60,65	heme oxygenase-1	Bach1	3162	571	Gene	Gene	START_ENTITY|advcl|suppressing suppressing|dobj|injury injury|amod|END_ENTITY	The let-7 microRNA enhances heme_oxygenase-1 by suppressing Bach1 and attenuates oxidant injury in human hepatocytes .
24613086	0	heme_oxygenase-1	55,71	Bach1	164,169	heme oxygenase-1	Bach1	3162	571	Gene	Gene	expression|amod|START_ENTITY Characterization|dep|expression Characterization|dep|importance importance|nmod|degradation degradation|appos|END_ENTITY	Characterization of docosahexaenoic_acid -LRB- DHA -RRB- - induced heme_oxygenase-1 -LRB- HO-1 -RRB- expression in human cancer cells : the importance of enhanced BTB_and_CNC_homology_1 -LRB- Bach1 -RRB- degradation .
17924972	0	heme_oxygenase-1	98,114	C-C_ligand_20	71,84	heme oxygenase-1	C-C ligand 20	3162	6364	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Substance_P regulates macrophage_inflammatory_protein_3alpha / chemokine C-C_ligand_20 -LRB- CCL20 -RRB- with heme_oxygenase-1 in human periodontal ligament cells .
12810075	0	heme_oxygenase-1	28,44	CD25	53,57	heme oxygenase-1	CD25	3162	3559	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Differential expressions of heme_oxygenase-1 gene in CD25 - and CD25 + subsets of human CD4 + T cells .
16214041	0	heme_oxygenase-1	40,56	ERK	103,106	heme oxygenase-1	ERK	15368(Tax:10090)	26413(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY upregulate|dobj|expression upregulate|nmod|macrophages macrophages|nmod|pathways pathways|compound|END_ENTITY	HMG-CoA reductase inhibitors upregulate heme_oxygenase-1 expression in murine RAW264 .7 macrophages via ERK , p38_MAPK and protein kinase G pathways .
17467702	0	heme_oxygenase-1	24,40	ERK	59,62	heme oxygenase-1	ERK	3162	5594	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Triphlorethol-A induces heme_oxygenase-1 via activation of ERK and NF-E2_related_factor_2 transcription factor .
22144097	0	heme_oxygenase-1	102,118	ERK	50,53	heme oxygenase-1	ERK	24451(Tax:10116)	24338(Tax:10116)	Gene	Gene	apoptosis|nmod|START_ENTITY apoptosis|nmod|END_ENTITY	Ampelopsin inhibits H ___ O - induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme_oxygenase-1 .
22147269	0	heme_oxygenase-1	16,32	ERK	54,57	heme oxygenase-1	ERK	24451(Tax:10116)	24338(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of heme_oxygenase-1 by acteoside through ERK and PI3_K / Akt pathway confer neuroprotection against beta-amyloid-induced neurotoxicity .
22466441	0	heme_oxygenase-1	21,37	ERK	56,59	heme oxygenase-1	ERK	3162	5594	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Ferulic_acid induces heme_oxygenase-1 via activation of ERK and Nrf2 .
23073806	0	heme_oxygenase-1	102,118	ERK	125,128	heme oxygenase-1	ERK	24451(Tax:10116)	24338(Tax:10116)	Gene	Gene	inducing|xcomp|START_ENTITY inducing|nmod|END_ENTITY	1,2,3,4,6-penta-O-galloyl-b-D-glucose protects PC12 Cells from MPP -LRB- + -RRB- - mediated cell death by inducing heme_oxygenase-1 in an ERK - and Akt-dependent manner .
17560935	0	heme_oxygenase-1	23,39	Erythropoietin	0,14	heme oxygenase-1	Erythropoietin	24451(Tax:10116)	24335(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Erythropoietin induces heme_oxygenase-1 expression and attenuates oxidative stress .
15870071	0	heme_oxygenase-1	35,51	Fibroblast_growth_factor-1	0,26	heme oxygenase-1	Fibroblast growth factor-1	24451(Tax:10116)	25317(Tax:10116)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Fibroblast_growth_factor-1 induces heme_oxygenase-1 via nuclear factor erythroid 2-related factor 2 -LRB- Nrf2 -RRB- in spinal cord astrocytes : consequences for motor neuron survival .
19578789	0	heme_oxygenase-1	74,90	HGF	51,54	heme oxygenase-1	HGF	15368(Tax:10090)	15234(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of IL-6 and IL-10 balance by HGF via recruitment of heme_oxygenase-1 in macrophages for attenuation of liver_injury in a mouse model of endotoxemia .
10413312	0	heme_oxygenase-1	39,55	HO-1	57,61	heme oxygenase-1	HO-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Coordinate up-regulation of CYP1A1 and heme_oxygenase-1 -LRB- HO-1 -RRB- expression and modulation of delta-aminolevulinic_acid synthase and tryptophan_pyrrolase activities in pyridine-treated rats .
11751428	0	heme_oxygenase-1	15,31	HO-1	33,37	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of heme_oxygenase-1 -LRB- HO-1 -RRB- in the adaptive protection of human lymphocytes after hyperbaric oxygen -LRB- HBO -RRB- treatment .
11948696	0	heme_oxygenase-1	31,47	HO-1	49,53	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Functional expression of human heme_oxygenase-1 -LRB- HO-1 -RRB- driven by HO-1 promoter in vitro and in vivo .
15081633	0	heme_oxygenase-1	32,48	HO-1	50,54	heme oxygenase-1	HO-1	15368(Tax:10090)	15368(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Marked developmental changes in heme_oxygenase-1 -LRB- HO-1 -RRB- expression in the mouse placenta : correlation between HO-1 expression and placental development .
15365571	0	heme_oxygenase-1	16,32	HO-1	34,38	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Polymorphism in heme_oxygenase-1 -LRB- HO-1 -RRB- promoter is related to the risk of oral_squamous_cell_carcinoma occurring on male areca chewers .
17486279	0	heme_oxygenase-1	14,30	HO-1	32,36	heme oxygenase-1	HO-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Assessment of heme_oxygenase-1 -LRB- HO-1 -RRB- activity in the cavernous tissues of sildenafil_citrate-treated rats .
17657593	0	heme_oxygenase-1	91,107	HO-1	109,113	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Structural influence of isothiocyanates on the antioxidant response element -LRB- ARE -RRB- - mediated heme_oxygenase-1 -LRB- HO-1 -RRB- expression .
19475336	0	heme_oxygenase-1	20,36	HO-1	38,42	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Genetic analysis of heme_oxygenase-1 -LRB- HO-1 -RRB- in German Parkinson 's _ disease patients .
19833168	0	heme_oxygenase-1	18,34	HO-1	36,40	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Rottlerin induces heme_oxygenase-1 -LRB- HO-1 -RRB- up-regulation through reactive oxygen species -LRB- ROS -RRB- dependent and PKC_delta-independent pathway in human colon_cancer HT29 cells .
19895178	0	heme_oxygenase-1	16,32	HO-1	34,38	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Polymorphism in heme_oxygenase-1 -LRB- HO-1 -RRB- promoter and alcohol are related to the risk of esophageal_squamous_cell_carcinoma on Chinese males .
21327520	0	heme_oxygenase-1	34,50	HO-1	52,56	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Ferrearin_C induces apoptosis via heme_oxygenase-1 -LRB- HO-1 -RRB- induction in neuroblastoma .
22158875	0	heme_oxygenase-1	31,47	HO-1	49,53	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-19 -LRB- IL-19 -RRB- induces heme_oxygenase-1 -LRB- HO-1 -RRB- expression and decreases reactive oxygen species in human vascular smooth muscle cells .
23746277	0	heme_oxygenase-1	11,27	HO-1	29,33	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	A focus on heme_oxygenase-1 -LRB- HO-1 -RRB- inhibitors .
8584240	0	heme_oxygenase-1	13,29	HO-1	31,35	heme oxygenase-1	HO-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HO-1 -RRB- after traumatic brain_injury in the rat .
8930310	0	heme_oxygenase-1	13,29	HO-1	31,35	heme oxygenase-1	HO-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HO-1 -RRB- in glia after traumatic_brain_injury .
9622586	0	heme_oxygenase-1	13,29	HO-1	31,35	heme oxygenase-1	HO-1	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HO-1 -RRB- in the contused spinal cord of the rat .
9890653	0	heme_oxygenase-1	45,61	HO-1	63,67	heme oxygenase-1	HO-1	3162	3162	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the antioxidant stress protein heme_oxygenase-1 -LRB- HO-1 -RRB- in human leukocytes .
17873285	0	heme_oxygenase-1	29,45	HSP32	47,52	heme oxygenase-1	HSP32	3162	3162	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Differential upregulation of heme_oxygenase-1 -LRB- HSP32 -RRB- in glial cells after oxidative stress and in demyelinating_disorders .
8423544	0	heme_oxygenase-1	20,36	HSP32	38,43	heme oxygenase-1	HSP32	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Induction of kidney heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA and protein by ischemia/reperfusion : possible role of heme as both promotor of tissue damage and regulator of HSP32 .
8455037	0	heme_oxygenase-1	30,46	HSP32	48,53	heme oxygenase-1	HSP32	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Glutathione depletion induces heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA and protein in rat brain .
8667253	0	heme_oxygenase-1	40,56	HSP32	58,63	heme oxygenase-1	HSP32	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Renal_ischemia / reperfusion up-regulates heme_oxygenase-1 -LRB- HSP32 -RRB- expression and increases cGMP in rat heart .
8722628	0	heme_oxygenase-1	93,109	HSP32	111,116	heme oxygenase-1	HSP32	24451(Tax:10116)	24451(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Stress response of the rat testis : in situ hydridization and immunohistochemical analysis of heme_oxygenase-1 -LRB- HSP32 -RRB- induction by hyperthermia .
9038811	0	heme_oxygenase-1	13,29	HSP32	31,36	heme oxygenase-1	HSP32	3162	3162	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Induction of heme_oxygenase-1 -LRB- HSP32 -RRB- mRNA in skeletal muscle following contractions .
24038883	0	heme_oxygenase-1	22,38	Heat_shock_protein_32	0,21	heme oxygenase-1	Heat shock protein 32	15368(Tax:10090)	15368(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY END_ENTITY|parataxis|protects	Heat_shock_protein_32 / heme_oxygenase-1 protects mouse Sertoli cells from hyperthermia-induced apoptosis by CO activation of sGC signalling pathways .
22158875	0	heme_oxygenase-1	31,47	Interleukin-19	0,14	heme oxygenase-1	Interleukin-19	3162	29949	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-19 -LRB- IL-19 -RRB- induces heme_oxygenase-1 -LRB- HO-1 -RRB- expression and decreases reactive oxygen species in human vascular smooth muscle cells .
17204476	0	heme_oxygenase-1	29,45	JunB	0,4	heme oxygenase-1	JunB	3162	3726	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	JunB and JunD regulate human heme_oxygenase-1 gene expression in renal epithelial cells .
11746786	0	heme_oxygenase-1	29,45	Myelin_basic_protein	0,20	heme oxygenase-1	Myelin basic protein	3162	4155	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Myelin_basic_protein induces heme_oxygenase-1 in human astroglial cells .
15882976	0	heme_oxygenase-1	24,40	NF-E2-related_factor_2	70,92	heme oxygenase-1	NF-E2-related factor 2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	Resveratrol upregulates heme_oxygenase-1 expression via activation of NF-E2-related_factor_2 in PC12 cells .
19628634	0	heme_oxygenase-1	123,139	NF-E2-related_factor_2	158,180	heme oxygenase-1	NF-E2-related factor 2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Lansoprazole , a proton pump inhibitor , mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme_oxygenase-1 via activation of NF-E2-related_factor_2 and oxidation of kelch-like_ECH-associating_protein_1 .
18073186	0	heme_oxygenase-1	15,31	NF-kappaB	42,51	heme oxygenase-1	NF-kappaB	15368(Tax:10090)	18033(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Statin-induced heme_oxygenase-1 increases NF-kappaB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide .
10473555	0	heme_oxygenase-1	70,86	Nrf2	0,4	heme oxygenase-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY induction|nmod|gene regulates|dobj|induction regulates|nsubj|END_ENTITY	Nrf2 , a Cap'n ` Collar transcription factor , regulates induction of the heme_oxygenase-1 gene .
12453873	0	heme_oxygenase-1	19,35	Nrf2	82,86	heme oxygenase-1	Nrf2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY activates|dobj|gene activates|nmod|END_ENTITY	Heme activates the heme_oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2 .
12699247	0	heme_oxygenase-1	60,76	Nrf2	128,132	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	induction|amod|START_ENTITY Interaction|nmod|induction Interaction|dep|involvement involvement|nmod|END_ENTITY	Interaction of heme with nitroxyl or nitric_oxide amplifies heme_oxygenase-1 induction : involvement of the transcription factor Nrf2 .
15870071	0	heme_oxygenase-1	35,51	Nrf2	101,105	heme oxygenase-1	Nrf2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	START_ENTITY|nmod|factor factor|acl|erythroid erythroid|dobj|factor factor|appos|END_ENTITY	Fibroblast_growth_factor-1 induces heme_oxygenase-1 via nuclear factor erythroid 2-related factor 2 -LRB- Nrf2 -RRB- in spinal cord astrocytes : consequences for motor neuron survival .
16482620	0	heme_oxygenase-1	54,70	Nrf2	97,101	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|advcl|stimulating stimulating|dobj|translocation translocation|amod|END_ENTITY	1,2,3,4,6-penta-O-galloyl-beta-D-glucose up-regulates heme_oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular_signal-regulated_kinase-dependent manner in HepG2 cells .
17535857	0	heme_oxygenase-1	14,30	Nrf2	76,80	heme oxygenase-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|demethoxy_curcuminoids demethoxy_curcuminoids|nmod|END_ENTITY	Regulation of heme_oxygenase-1 expression by demethoxy_curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells .
20064636	0	heme_oxygenase-1	13,29	Nrf2	121,125	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	Induction|nmod|START_ENTITY lymphocytes|nsubj|Induction lymphocytes|parataxis|requires requires|dobj|END_ENTITY	Induction of heme_oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta -LRB- 12,14 -RRB- - prostaglandin_J -LRB- 2 -RRB- requires Nrf2 .
20074672	0	heme_oxygenase-1	27,43	Nrf2	59,63	heme oxygenase-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Taurine_chloramine induces heme_oxygenase-1 expression via Nrf2 activation in murine macrophages .
20486211	0	heme_oxygenase-1	125,141	Nrf2	106,110	heme oxygenase-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY activation|nmod|induction END_ENTITY|acl|activation	Inhibition of neointimal formation by trans-resveratrol : role of phosphatidyl_inositol 3-kinase-dependent Nrf2 activation in heme_oxygenase-1 induction .
20558128	0	heme_oxygenase-1	20,36	Nrf2	115,119	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Piceatannol induces heme_oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling .
20920477	0	heme_oxygenase-1	49,65	Nrf2	99,103	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|activation activation|nmod|END_ENTITY	Low concentration of 4-hydroxy_hexenal increases heme_oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells .
22095074	0	heme_oxygenase-1	22,38	Nrf2	72,76	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Guggulsterone induces heme_oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells : PTEN as a putative target .
23036869	0	heme_oxygenase-1	44,60	Nrf2	93,97	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	induction|amod|START_ENTITY reductase|dobj|induction reductase|nmod|inhibition inhibition|nmod|activation activation|amod|END_ENTITY	Methionine_sulfoxide reductase A attenuates heme_oxygenase-1 induction through inhibition of Nrf2 activation .
23318726	0	heme_oxygenase-1	117,133	Nrf2	94,98	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expressions|amod|START_ENTITY expressions|amod|END_ENTITY	Butein protects human_dental_pulp cells from hydrogen_peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme_oxygenase-1 expressions .
23567851	0	heme_oxygenase-1	21,37	Nrf2	74,78	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Homocysteine induces heme_oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cell .
24063008	0	heme_oxygenase-1	59,75	Nrf2	100,104	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Cordyceps sinensis increases hypoxia tolerance by inducing heme_oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells .
25871879	0	heme_oxygenase-1	89,105	Nrf2	121,125	heme oxygenase-1	Nrf2	15368(Tax:10090)	18024(Tax:10090)	Gene	Gene	independent|amod|START_ENTITY independent|nmod|activation activation|amod|END_ENTITY	Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme_oxygenase-1 independent of Nrf2 activation .
26291278	0	heme_oxygenase-1	121,137	Nrf2	26,30	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	gene|amod|START_ENTITY transcription|nmod|gene phosphorylation|nmod|transcription serine|dobj|phosphorylation serine|nsubj|regulation regulation|nmod|END_ENTITY	Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme_oxygenase-1 gene .
26404762	0	heme_oxygenase-1	65,81	Nrf2	116,120	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expression|amod|START_ENTITY down-regulated|dobj|expression down-regulated|advcl|inhibiting inhibiting|dobj|pathways pathways|compound|END_ENTITY	2,3,5,6-Tetramethylpyrazine -LRB- TMP -RRB- down-regulated arsenic-induced heme_oxygenase-1 and ARS2 expression by inhibiting Nrf2 , NF-kB , AP-1 and MAPK pathways in human proximal tubular cells .
26445536	0	heme_oxygenase-1	26,42	Nrf2	62,66	heme oxygenase-1	Nrf2	3162	4780	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nmod|activation activation|amod|END_ENTITY	Gold nanoparticles induce heme_oxygenase-1 expression through Nrf2 activation and Bach1 export in human vascular endothelial cells .
23074199	0	heme_oxygenase-1	22,38	Osteopontin	0,11	heme oxygenase-1	Osteopontin	15368(Tax:10090)	6696	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Osteopontin increases heme_oxygenase-1 expression and subsequently induces cell migration and invasion in glioma cells .
18554677	0	heme_oxygenase-1	108,124	PI3K	130,134	heme oxygenase-1	PI3K	3162	5293	Gene	Gene	START_ENTITY|nmod|manner manner|compound|END_ENTITY	Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme_oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner .
20307651	0	heme_oxygenase-1	71,87	Pin1	102,106	heme oxygenase-1	Pin1	15368(Tax:10090)	23988(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Role of Pin1 in neointima formation : down-regulation of Nrf2-dependent heme_oxygenase-1 expression by Pin1 .
10330231	0	heme_oxygenase-1	31,47	TNF-alpha	0,9	heme oxygenase-1	TNF-alpha	3162	7124	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	TNF-alpha and IL-1alpha induce heme_oxygenase-1 via protein_kinase_C , Ca2 + , and phospholipase_A2 in endothelial cells .
18234118	0	heme_oxygenase-1	23,39	Toll-like_receptor_4	55,75	heme oxygenase-1	Toll-like receptor 4	3162	7099	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Association of reduced heme_oxygenase-1 with excessive Toll-like_receptor_4 expression in peripheral blood mononuclear cells in Beh et 's disease .
17307160	0	heme_oxygenase-1	44,60	Transforming_growth_factor-beta1	0,32	heme oxygenase-1	Transforming growth factor-beta1	3162	7040	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 stimulates heme_oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells .
22426130	0	heme_oxygenase-1	71,87	VEGFR2	92,98	heme oxygenase-1	VEGFR2	3162	3791	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|compound|END_ENTITY	PDGF-induced migration of vascular smooth muscle cells is inhibited by heme_oxygenase-1 via VEGFR2 upregulation and subsequent assembly of inactive VEGFR2/PDGFRb heterodimers .
14523007	0	heme_oxygenase-1	50,66	cAMP-responsive_element-binding_protein	91,130	heme oxygenase-1	cAMP-responsive element-binding protein	3162	1385	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Oxidized phospholipids induce expression of human heme_oxygenase-1 involving activation of cAMP-responsive_element-binding_protein .
15618017	0	heme_oxygenase-1	71,87	heat_shock_factor-1	21,40	heme oxygenase-1	heat shock factor-1	3162	3297	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	The possible role of heat_shock_factor-1 in the negative regulation of heme_oxygenase-1 .
26337933	0	heme_oxygenase-1	24,40	hmox1	42,47	heme oxygenase-1	hmox1	3162	3162	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	Leukocyte expression of heme_oxygenase-1 -LSB- hmox1 -RSB- varies inversely with severity of tricuspid_regurgitation in acute_pulmonary_embolism .
10349844	0	heme_oxygenase-1	15,31	interferon-gamma	51,67	heme oxygenase-1	interferon-gamma	3162	3458	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of heme_oxygenase-1 mRNA expression by interferon-gamma in human glioblastoma cells .
16510205	0	heme_oxygenase-1	18,34	interleukin-6	49,62	Heme oxygenase-1	interleukin-6	24451(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of rat heme_oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes .
18547752	0	heme_oxygenase-1	25,41	interleukin-6	72,85	heme oxygenase-1	interleukin-6	24451(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of hepatic heme_oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon_tetrachloride intraperitoneally .
23615401	0	heme_oxygenase-1	13,29	matrix_metalloproteinase-9	60,86	heme oxygenase-1	matrix metalloproteinase-9	3162	4318	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of heme_oxygenase-1 and inhibition of TPA-induced matrix_metalloproteinase-9 expression by andrographolide in MCF-7 human breast_cancer cells .
19131520	0	heme_oxygenase-1	36,52	membrane-bound	15,29	heme oxygenase-1	membrane-bound	3162	19	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Measurement of membrane-bound human heme_oxygenase-1 activity using a chemically defined assay system .
21106538	0	heme_oxygenase-1	14,30	miR-217	81,88	heme oxygenase-1	miR-217	3162	406999	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of heme_oxygenase-1 protein expression by miR-377 in combination with miR-217 .
21106538	0	heme_oxygenase-1	14,30	miR-377	53,60	heme oxygenase-1	miR-377	3162	494326	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of heme_oxygenase-1 protein expression by miR-377 in combination with miR-217 .
16123320	0	heme_oxygenase-1	26,42	nuclear_factor_erythroid_2-related_factor_2	69,112	heme oxygenase-1	nuclear factor erythroid 2-related factor 2	3162	4780	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|advcl|END_ENTITY	Alpha-lipoic_acid-induced heme_oxygenase-1 expression is mediated by nuclear_factor_erythroid_2-related_factor_2 and p38_mitogen-activated_protein_kinase in human monocytic cells .
16849502	0	heme_oxygenase-1	28,44	p38	94,97	heme oxygenase-1	p38	3162	1432	Gene	Gene	effect|nmod|START_ENTITY involves|nsubj|effect involves|dobj|degradation degradation|nmod|isoform isoform|amod|END_ENTITY	The antiapoptotic effect of heme_oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform .
18846504	0	heme_oxygenase-1	82,98	p38	4,7	heme oxygenase-1	p38	24451(Tax:10116)	81649(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY regulation|nmod|cells involved|nmod|regulation involved|nsubjpass|kinase kinase|amod|END_ENTITY	The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme_oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells .
20822529	0	heme_oxygenase-1	87,103	p38	121,124	heme oxygenase-1	p38	3162	1432	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Hemin inhibits NO production by IL-1b-stimulated human astrocytes through induction of heme_oxygenase-1 and reduction of p38 MAPK activation .
20954800	0	heme_oxygenase-1	64,80	p38	19,22	heme oxygenase-1	p38	15368(Tax:10090)	26416(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells pathway|nmod|induction pathway|amod|END_ENTITY	Involvement of the p38 pathway in the differential induction of heme_oxygenase-1 by statins in Neuro-2A cells exposed to lipopolysaccharide .
22137262	0	heme_oxygenase-1	47,63	p38	89,92	heme oxygenase-1	p38	3162	1432	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|MAPK MAPK|amod|END_ENTITY	Epigallocatechin gallate induces expression of heme_oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-a .
22369644	0	heme_oxygenase-1	23,39	p38	48,51	heme oxygenase-1	p38	15368(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Ethyl_pyruvate induces heme_oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals .
22875631	0	heme_oxygenase-1	4,20	p38	101,104	heme oxygenase-1	p38	3162	1432	Gene	Gene	ZnPPIX|amod|START_ENTITY induces|nsubj|ZnPPIX induces|xcomp|autophagy autophagy|nmod|pathway pathway|amod|END_ENTITY	The heme_oxygenase-1 inhibitor ZnPPIX induces non-canonical , Beclin_1-independent , autophagy through p38 MAPK pathway .
14688281	0	heme_oxygenase-1	14,30	phosphatidylinositol_3-kinase	54,83	heme oxygenase-1	phosphatidylinositol 3-kinase	15368(Tax:10090)	18708(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Regulation of heme_oxygenase-1 expression through the phosphatidylinositol_3-kinase / Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol .
8163576	0	heme_oxygenase-1	24,40	transforming_growth_factor-beta	86,117	heme oxygenase-1	transforming growth factor-beta	3162	7040	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Increased expression of heme_oxygenase-1 in human retinal pigment epithelial cells by transforming_growth_factor-beta .
17567933	0	heme_oxygenase-1	61,77	transforming_growth_factor-beta1	86,118	heme oxygenase-1	transforming growth factor-beta1	3162	7040	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Specificity_protein_1 and Smad-dependent regulation of human heme_oxygenase-1 gene by transforming_growth_factor-beta1 in renal epithelial cells .
9721696	0	heme_oxygenase-1	13,29	transforming_growth_factor-beta1	69,101	heme oxygenase-1	transforming growth factor-beta1	24451(Tax:10116)	59086(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY downregulated|nsubjpass|Induction downregulated|advcl|END_ENTITY	Induction of heme_oxygenase-1 during endotoxemia is downregulated by transforming_growth_factor-beta1 .
9530200	0	heme_oxygenase-1	65,81	tumor_necrosis_factor-alpha	10,37	heme oxygenase-1	tumor necrosis factor-alpha	3162	7124	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha and interleukin-1_alpha on heme_oxygenase-1 expression in human endothelial cells .
25641586	0	heme_oxygenase_1	34,50	CD4	104,107	heme oxygenase 1	CD4	15368(Tax:10090)	12504(Tax:10090)	Gene	Gene	control|nmod|START_ENTITY required|nsubjpass|control required|advcl|restoring restoring|dobj|function function|compound|END_ENTITY	Micro-RNA-155-mediated control of heme_oxygenase_1 -LRB- HO-1 -RRB- is required for restoring adaptively tolerant CD4 -LRB- + -RRB- T-cell function in rodents .
26488466	0	heme_oxygenase_1	18,34	HO-1	36,40	heme oxygenase 1	HO-1	3162	3162	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Downregulation of heme_oxygenase_1 -LRB- HO-1 -RRB- activity in hematopoietic cells enhances their engraftment after transplantation .
16574070	0	heme_oxygenase_1	25,41	Nrf2	56,60	heme oxygenase 1	Nrf2	3162	4780	Gene	Gene	induction|amod|START_ENTITY induction|nmod|activation activation|amod|END_ENTITY	Carbon_monoxide mediates heme_oxygenase_1 induction via Nrf2 activation in hepatoma cells .
23779049	0	heme_oxygenase_1	18,34	PPAR	0,4	heme oxygenase 1	PPAR	24451(Tax:10116)	25747(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|compound|END_ENTITY	PPAR binding to heme_oxygenase_1 promoter prevents angiotensin_II-induced adipocyte_dysfunction in Goldblatt hypertensive rats .
17452746	0	heme_oxygenase_1	36,52	SREBP-1	0,7	heme oxygenase 1	SREBP-1	15368(Tax:10090)	20787(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SREBP-1 regulates the expression of heme_oxygenase_1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma .
11302771	0	heme_oxygenase_1	13,29	angiotensin_II	64,78	heme oxygenase 1	angiotensin II	24451(Tax:10116)	24179(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|role role|nmod|END_ENTITY	Induction of heme_oxygenase_1 in radiation nephropathy : role of angiotensin_II .
24755082	0	hemeoxygenase-1	14,29	Nrf2	49,53	hemeoxygenase-1	Nrf2	24451(Tax:10116)	83619(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of hemeoxygenase-1 gene expression by Nrf2 and c-Jun in tertiary_butylhydroquinone-stimulated rat primary astrocytes .
10578067	0	hemidesmosomal_500_kDa_protein	22,52	plectin	62,69	hemidesmosomal 500 kDa protein	plectin	404126(Tax:9913)	786966(Tax:9913)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the hemidesmosomal_500_kDa_protein -LRB- HD1 -RRB- as plectin .
12364722	0	hemochromatosis	17,32	HFE	39,42	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the hemochromatosis gene -LRB- HFE -RRB- and stroke .
12902032	0	hemochromatosis	17,32	HFE	39,42	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the hemochromatosis gene -LRB- HFE -RRB- , Parkinson 's _ disease and parkinsonism .
15017658	0	hemochromatosis	48,63	HFE	70,73	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Natural history of the C282Y homozygote for the hemochromatosis gene -LRB- HFE -RRB- with a normal serum ferritin level .
15955425	0	hemochromatosis	17,32	HFE	39,42	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the hemochromatosis gene -LRB- HFE -RRB- and multiple_sclerosis .
17013646	0	hemochromatosis	17,32	HFE	39,42	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequency of the hemochromatosis gene -LRB- HFE -RRB- 282C -- > Y , 63H -- > D , and 65S -- > C mutations in a general Mediterranean population from Tarragona , Spain .
19822954	0	hemochromatosis	17,32	HFE	39,42	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequency of the hemochromatosis gene -LRB- HFE -RRB- variants in a Jordanian Arab population and in diabetics from the same region .
8304342	0	hemochromatosis	100,115	HFE	122,125	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene -LRB- HFE -RRB- The hemochromatosis gene -LRB- HFE -RRB- maps to 6p21 .3 and is less than 1 cM from the HLA class I genes ; however , the precise physical location of the gene has remained elusive and controversial .
9789968	0	hemochromatosis	5,20	HFE	27,30	hemochromatosis	HFE	3077	3077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The hemochromatosis gene -LRB- HFE -RRB- .
19099662	0	hemoglobin	16,26	TNF-alpha	57,66	hemoglobin	TNF-alpha	100323610(Tax:9823)	397086(Tax:9823)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of free hemoglobin on hemorrhagic_shock in pigs : TNF-alpha , IL-6 expressions in serum and rates of MODS after the blood transfusion -RSB- .
4080960	0	hemoglobin_A2	18,31	HbA2	33,37	hemoglobin A2	HbA2	3040	3040	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of hemoglobin_A2 -LRB- HbA2 -RRB- by ion exchange resins freely suspended in test tubes -RSB- .
15916057	0	hemoglobin_E	47,59	Hemoglobin_E	0,12	hemoglobin E	Hemoglobin E	3046	3046	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Hemoglobin_E levels in double heterozygotes of hemoglobin_E and SEA-type_alpha-thalassemia .
11756196	0	hemoglobin_scavenger_receptor	22,51	CD163	52,57	hemoglobin scavenger receptor	CD163	9332	9332	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of the hemoglobin_scavenger_receptor / CD163 as a natural soluble protein in plasma .
19961729	0	hemoglobin_scavenger_receptor	21,50	CD163	51,56	hemoglobin scavenger receptor	CD163	9332	9332	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	-LSB- Association between hemoglobin_scavenger_receptor CD163 expression and coronary atherosclerotic severity in patients with coronary_heart_disease -RSB- .
20937842	0	hemojuvelin	57,68	Matriptase-2	0,12	hemojuvelin	Matriptase-2	148738	164656	Gene	Gene	forms|nmod|START_ENTITY forms|amod|END_ENTITY	Matriptase-2 - and proprotein convertase-cleaved forms of hemojuvelin have different roles in the down-regulation of hepcidin expression .
23095116	0	hemojuvelin	29,40	congenital_dyserythropoietic_anemia_type_I	58,100	hemojuvelin	congenital dyserythropoietic anemia type I	148738	146059	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	High levels of soluble serum hemojuvelin in patients with congenital_dyserythropoietic_anemia_type_I .
18211098	0	hemopexin	53,62	ORF3	4,8	hemopexin	ORF3	3263	9725255	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	The ORF3 protein of hepatitis_E_virus interacts with hemopexin by means of its 26 amino_acid_N-terminal hydrophobic domain II .
8031836	0	hemopexin	40,49	heme	24,28	hemopexin	heme	100009541(Tax:9986)	100307951(Tax:9913)	Gene	Gene	complex|nmod|START_ENTITY complex|amod|END_ENTITY	Proton NMR study of the heme complex of hemopexin .
21646471	0	hemopexin	59,68	matrix_metalloproteinase-9	79,105	hemopexin	matrix metalloproteinase-9	3263	4318	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Small-molecule anticancer compounds selectively target the hemopexin domain of matrix_metalloproteinase-9 .
26648034	0	hemopexin	36,45	matrix_metalloproteinase-9	62,88	hemopexin	matrix metalloproteinase-9	3263	4318	Gene	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Signatures of positive selection at hemopexin -LRB- PEX -RRB- domain of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene .
15381707	0	hemopexin	4,13	membrane-type_matrix_metalloproteinase-1	24,64	hemopexin	membrane-type matrix metalloproteinase-1	3263	4323	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The hemopexin domain of membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen .
9670936	0	hemopoietic_specific_protein_1	63,93	Grb2	40,44	hemopoietic specific protein 1	Grb2	15163(Tax:10090)	14784(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- association with hemopoietic_specific_protein_1 : linkage between Lck and Grb2 .
9670936	0	hemopoietic_specific_protein_1	63,93	Growth_factor_receptor-bound_protein_2	0,38	hemopoietic specific protein 1	Growth factor receptor-bound protein 2	15163(Tax:10090)	14784(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Growth_factor_receptor-bound_protein_2 -LRB- Grb2 -RRB- association with hemopoietic_specific_protein_1 : linkage between Lck and Grb2 .
20638466	0	heparan_sulfate_proteoglycan	21,49	HSPG	51,55	heparan sulfate proteoglycan	HSPG	960	960	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glial cells modulate heparan_sulfate_proteoglycan -LRB- HSPG -RRB- expression by neuronal precursors during early postnatal cerebellar development .
8292358	0	heparan_sulfate_proteoglycan	21,49	Perlecan	51,59	heparan sulfate proteoglycan	Perlecan	25615(Tax:10116)	313641(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	An important role of heparan_sulfate_proteoglycan -LRB- Perlecan -RRB- in a model system for the deposition and persistence of fibrillar A_beta-amyloid in rat brain .
9184982	0	heparan_sulfate_proteoglycan	50,78	agrin	41,46	heparan sulfate proteoglycan	agrin	960	375790	Gene	Gene	properties|appos|START_ENTITY properties|nmod|END_ENTITY	Distribution and substrate properties of agrin , a heparan_sulfate_proteoglycan of developing axonal pathways .
14563633	0	heparan_sulfate_proteoglycan	79,107	antithrombin	15,27	heparan sulfate proteoglycan	antithrombin	960	462	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan_sulfate_proteoglycan , perlecan , in endothelial cells .
8698830	0	heparan_sulfate_proteoglycan	32,60	perlecan	62,70	heparan sulfate proteoglycan	perlecan	25615(Tax:10116)	313641(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Regulation of basement membrane heparan_sulfate_proteoglycan , perlecan , gene expression in glomerular epithelial cells by high glucose medium .
12652971	0	heparan_sulfate_proteoglycan	8,36	syndecan-1	38,48	heparan sulfate proteoglycan	syndecan-1	25216(Tax:10116)	482986(Tax:9615)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of heparan_sulfate_proteoglycan -LRB- syndecan-1 -RRB- on the renal epithelial cells during calcium_oxalate monohydrate crystal attachment .
12713442	0	heparanase	69,79	Hpa1	81,85	heparanase	Hpa1	10855	10855	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Biochemical characterization of the active heterodimer form of human heparanase -LRB- Hpa1 -RRB- protein expressed in insect cells .
11027606	0	heparanase	60,70	Hpa2	36,40	heparanase	Hpa2	10855	60495	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Cloning and expression profiling of Hpa2 , a novel mammalian heparanase family member .
16474844	0	heparanase	31,41	p53	17,20	heparanase	p53	10855	7157	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor suppressor p53 regulates heparanase gene expression .
11779847	0	heparanase-1	42,54	HPR1	56,60	heparanase-1	HPR1	10855	10855	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Cloning and characterization of the human heparanase-1 -LRB- HPR1 -RRB- gene promoter : role of GA-binding protein and Sp1 in regulating HPR1 basal promoter activity .
12746188	0	heparin-binding_EGF-like_growth_factor	27,65	HB-EGF	67,73	heparin-binding EGF-like growth factor	HB-EGF	25433(Tax:10116)	25433(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of endogenous heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- expression after intestinal_ischemia / reperfusion injury .
14756521	0	heparin-binding_EGF-like_growth_factor	27,65	HB-EGF	67,73	heparin-binding EGF-like growth factor	HB-EGF	1839	1839	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Differential expression of heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- mRNA in normal human keratinocytes induced by a variety of natural and synthetic retinoids .
16364500	0	heparin-binding_EGF-like_growth_factor	44,82	HB-EGF	84,90	heparin-binding EGF-like growth factor	HB-EGF	25433(Tax:10116)	25433(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Tissue distribution and plasma clearance of heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- in adult and newborn rats .
11432822	0	heparin-binding_EGF-like_growth_factor	57,95	N-arginine_dibasic_convertase	0,29	heparin-binding EGF-like growth factor	N-arginine dibasic convertase	1839	4898	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	N-arginine_dibasic_convertase is a specific receptor for heparin-binding_EGF-like_growth_factor that mediates cell migration .
17960400	0	heparin-binding_EGF-like_growth_factor	12,50	TNFalpha	132,140	heparin-binding EGF-like growth factor	TNFalpha	1839	7124	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of heparin-binding_EGF-like_growth_factor and amphiregulin in the epidermal proliferation of psoriasis in cooperation with TNFalpha .
11296226	0	heparin-binding_EGF-like_growth_factor	17,55	p53	0,3	heparin-binding EGF-like growth factor	p53	1839	7157	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	p53 induction of heparin-binding_EGF-like_growth_factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades .
11296226	0	heparin-binding_EGF-like_growth_factor	17,55	p53	68,71	heparin-binding EGF-like growth factor	p53	1839	7157	Gene	Gene	induction|nmod|START_ENTITY counteracts|nsubj|induction counteracts|dobj|suppression suppression|compound|END_ENTITY	p53 induction of heparin-binding_EGF-like_growth_factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades .
21854110	0	heparin-binding_EGF-like_growth_factor	10,48	vascular_endothelial_growth_factor	106,140	heparin-binding EGF-like growth factor	vascular endothelial growth factor	1839	7422	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of heparin-binding_EGF-like_growth_factor and amphiregulin on the MAP kinase-induced production of vascular_endothelial_growth_factor by human granulosa cells .
9869605	0	heparin-binding_epidermal_growth_factor-like_growth_factor	16,74	Gastrin	0,7	heparin-binding epidermal growth factor-like growth factor	Gastrin	25433(Tax:10116)	25320(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Gastrin induces heparin-binding_epidermal_growth_factor-like_growth_factor in rat gastric epithelial cells transfected with gastrin_receptor .
12028437	0	heparin-binding_epidermal_growth_factor-like_growth_factor	23,81	HB-EGF	83,89	heparin-binding epidermal growth factor-like growth factor	HB-EGF	25433(Tax:10116)	25433(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of membrane-bound heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- in renal epithelial cell branching .
22342671	0	heparin-binding_epidermal_growth_factor-like_growth_factor	47,105	HB-EGF	107,113	heparin-binding epidermal growth factor-like growth factor	HB-EGF	1839	1839	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The cell-penetrating peptide domain from human heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- has anti-inflammatory activity in vitro and in vivo .
8592081	0	heparin-binding_epidermal_growth_factor-like_growth_factor	14,72	HB-EGF	74,80	heparin-binding epidermal growth factor-like growth factor	HB-EGF	1839	1839	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- at sites of thermal_injury in pediatric patients .
20586780	0	heparin-binding_epidermal_growth_factor-like_growth_factor	37,95	Matrix_metalloproteinase-7	0,26	heparin-binding epidermal growth factor-like growth factor	Matrix metalloproteinase-7	1839	4316	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Matrix_metalloproteinase-7 activates heparin-binding_epidermal_growth_factor-like_growth_factor in cutaneous_squamous_cell_carcinoma .
9468491	0	heparin-binding_epidermal_growth_factor-like_growth_factor	43,101	Vascular_endothelial_growth_factor	0,34	heparin-binding epidermal growth factor-like growth factor	Vascular endothelial growth factor	1839	7422	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces heparin-binding_epidermal_growth_factor-like_growth_factor in vascular endothelial cells .
26440329	0	heparin-binding_epidermal_growth_factor-like_growth_factor	95,153	erbB2	204,209	heparin-binding epidermal growth factor-like growth factor	erbB2	522921(Tax:9913)	505709(Tax:9913)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
7722643	0	heparin-binding_growth-associated_molecule	12,54	HB-GAM	56,62	heparin-binding growth-associated molecule	HB-GAM	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- in the postsynaptic induction in cultured muscle cells .
8653419	0	heparin-binding_growth-associated_molecule	39,81	HB-GAM	83,89	heparin-binding growth-associated molecule	HB-GAM	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of the heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- in the developing and adult rat cerebellar cortex .
8812110	0	heparin-binding_growth-associated_molecule	16,58	HB-GAM	8,14	heparin-binding growth-associated molecule	HB-GAM	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of HB-GAM -LRB- heparin-binding_growth-associated_molecule -RRB- in proliferation arrest in cells of the developing rat limb and its expression in the differentiating neuromuscular system .
9389569	0	heparin-binding_growth-associated_molecule	55,97	HB-GAM	99,105	heparin-binding growth-associated molecule	HB-GAM	5764	5764	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression and biological activity of the heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- in lung_cancer cell lines .
9753126	0	heparin-binding_growth-associated_molecule	10,52	HB-GAM	54,60	heparin-binding growth-associated molecule	HB-GAM	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of heparin-binding_growth-associated_molecule -LRB- HB-GAM -RRB- on synaptic transmission and early LTP in rat hippocampal slices .
1898777	0	heparin-binding_growth_factor_2	24,55	Interleukin_1	0,13	heparin-binding growth factor 2	Interleukin 1	2247	3552	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin_1 regulates heparin-binding_growth_factor_2 gene expression in vascular smooth muscle cells .
1477961	0	heparin-binding_neurite-promoting_factor	24,64	HBNF	18,22	heparin-binding neurite-promoting factor	HBNF	24924(Tax:10116)	24924(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Expression of the HBNF -LRB- heparin-binding_neurite-promoting_factor -RRB- gene in the brain of fetal , neonatal and adult rat : an in situ hybridization study .
2480118	0	heparin-binding_protein	48,71	GMP-140	35,42	heparin-binding protein	GMP-140	566	6403	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of human platelet GMP-140 as a heparin-binding_protein .
20013808	0	heparin_affin_regulatory_peptide	43,75	U87	83,86	heparin affin regulatory peptide	U87	5764	641648	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	Antitumorigenic effects of a mutant of the heparin_affin_regulatory_peptide on the U87 MG_glioblastoma cell line .
17091770	0	heparin_affin_regulatory_peptide	10,42	vascular_endothelial_growth_factor	64,98	heparin affin regulatory peptide	vascular endothelial growth factor	5764	7422	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|receptors receptors|compound|END_ENTITY	Effect of heparin_affin_regulatory_peptide on the expression of vascular_endothelial_growth_factor receptors in endothelial cells .
17908800	0	heparin_affin_regulatory_peptide	187,219	vascular_endothelial_growth_factor	145,179	heparin affin regulatory peptide	vascular endothelial growth factor	19242(Tax:10090)	22339(Tax:10090)	Gene	Gene	pleiotrophin|amod|START_ENTITY tissue_growth_factor|nsubj|pleiotrophin Identification|parataxis|tissue_growth_factor Identification|acl|processed processed|nmod|matrix_metalloproteinase_2 matrix_metalloproteinase_2|dep|disruption disruption|nmod|END_ENTITY	Identification of candidate angiogenic inhibitors processed by matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in cell-based proteomic screens : disruption of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / heparin_affin_regulatory_peptide -LRB- pleiotrophin -RRB- and VEGF/Connective _ tissue_growth_factor angiogenic inhibitory complexes by MMP-2 proteolysis .
10210777	0	heparin_binding_epidermal_growth_factor-like_growth_factor	142,200	HB-EGF	202,208	heparin binding epidermal growth factor-like growth factor	HB-EGF	1839	1839	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Adhesion of human monocytic THP-1 cells to endothelial_cell_adhesion_molecules or extracellular matrix proteins via beta1_integrins regulates heparin_binding_epidermal_growth_factor-like_growth_factor -LRB- HB-EGF -RRB- expression .
10209287	0	heparin_cofactor_II	23,42	thrombin	71,79	heparin cofactor II	thrombin	3053	2147	Gene	Gene	residues|nmod|START_ENTITY required|nsubj|residues required|nmod|stimulation stimulation|nmod|inhibition inhibition|compound|END_ENTITY	Amino_acid residues of heparin_cofactor_II required for stimulation of thrombin inhibition by sulphated polyanions .
10488098	0	heparin_cofactor_II	91,110	thrombin	66,74	heparin cofactor II	thrombin	3053	2147	Gene	Gene	sulfate-mediated|nmod|START_ENTITY sulfate-mediated|dobj|catalysis catalysis|nmod|inactivation inactivation|compound|END_ENTITY	Comparison of heparin - and dermatan sulfate-mediated catalysis of thrombin inactivation by heparin_cofactor_II .
11051806	0	heparin_cofactor_II	11,30	thrombin	78,86	heparin cofactor II	thrombin	3053	2147	Gene	Gene	Effect|nmod|START_ENTITY measured|nsubj|Effect measured|nmod|methods methods|compound|END_ENTITY	-LSB- Effect of heparin_cofactor_II on the antithrombin_III activities measured by thrombin methods or factor_Xa methods -- fundamental studies and clinical studies using the plasma of pregnant women -RSB- .
11068038	0	heparin_cofactor_II	74,93	thrombin	31,39	heparin cofactor II	thrombin	3053	2147	Gene	Gene	aptamer|nmod|START_ENTITY aptamer|nsubj|Effect Effect|nmod|END_ENTITY	Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin_cofactor_II and antithrombin .
11068038	0	heparin_cofactor_II	74,93	thrombin	51,59	heparin cofactor II	thrombin	3053	2147	Gene	Gene	aptamer|nmod|START_ENTITY aptamer|nmod|inhibition inhibition|compound|END_ENTITY	Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin_cofactor_II and antithrombin .
12095635	0	heparin_cofactor_II	49,68	thrombin	110,118	heparin cofactor II	thrombin	3053	2147	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Contribution of basic residues of the A helix of heparin_cofactor_II to heparin - or dermatan sulfate-mediated thrombin inhibition .
14701814	0	heparin_cofactor_II	83,102	thrombin	71,79	heparin cofactor II	thrombin	3053	2147	Gene	Gene	pathway|nmod|START_ENTITY pathway|nmod|END_ENTITY	The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin_cofactor_II .
1646716	1	heparin_cofactor_II	127,146	thrombin	102,110	heparin cofactor II	thrombin	100009170(Tax:9986)	100009146(Tax:9986)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|inactivation inactivation|compound|END_ENTITY	Their glycosaminoglycan-dependent modulatory effects on thrombin inactivation by heparin_cofactor_II and antithrombin III .
16981704	0	heparin_cofactor_II	68,87	thrombin	160,168	heparin cofactor II	thrombin	3053	2147	Gene	Gene	extension|nmod|START_ENTITY fusion|nmod|extension increases|nsubj|fusion increases|dobj|rate rate|nmod|inhibition inhibition|compound|END_ENTITY	The transferable tail : fusion of the N-terminal acidic extension of heparin_cofactor_II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition .
18000606	0	heparin_cofactor_II	28,47	thrombin	186,194	heparin cofactor II	thrombin	15160(Tax:10090)	14061(Tax:10090)	Gene	Gene	region|nmod|START_ENTITY combine|nsubj|region combine|xcomp|increase increase|dobj|reactivity reactivity|nmod|M358R M358R|nmod|END_ENTITY	The appended tail region of heparin_cofactor_II and additional reactive centre loop mutations combine to increase the reactivity and specificity of alpha1-proteinase inhibitor M358R for thrombin .
18383370	0	heparin_cofactor_II	58,77	thrombin	30,38	heparin cofactor II	thrombin	3053	2147	Gene	Gene	inhibition|nmod|START_ENTITY protects|nmod|inhibition protects|dobj|END_ENTITY	Beta2-glycoprotein_I protects thrombin from inhibition by heparin_cofactor_II : potentiation of this effect in the presence of anti-beta2-glycoprotein_I autoantibodies .
19046760	0	heparin_cofactor_II	36,55	thrombin	13,21	heparin cofactor II	thrombin	3053	2147	Gene	Gene	inhibition|nmod|START_ENTITY dermatan|amod|inhibition dermatan|compound|END_ENTITY	Mechanism of thrombin inhibition by heparin_cofactor_II and antithrombin in the presence of the ray -LRB- Raja radula -RRB- skin dermatan sulfate .
20053992	0	heparin_cofactor_II	69,88	thrombin	44,52	heparin cofactor II	thrombin	3053	2147	Gene	Gene	accelerates|nmod|START_ENTITY accelerates|dobj|inactivation inactivation|compound|END_ENTITY	Sucrose_octasulfate selectively accelerates thrombin inactivation by heparin_cofactor_II .
2512688	0	heparin_cofactor_II	29,48	thrombin	15,23	heparin cofactor II	thrombin	3053	2147	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin with heparin_cofactor_II and antithrombin_III on prostacyclin production by cultured endothelial cells .
3401503	0	heparin_cofactor_II	94,113	thrombin	71,79	heparin cofactor II	thrombin	3053	2147	Gene	Gene	inhibition|nmod|START_ENTITY Studies|acl|inhibition Studies|nmod|END_ENTITY	Studies on the structural requirements of heparin for the catalysis of thrombin inhibition by heparin_cofactor_II .
3675584	0	heparin_cofactor_II	60,79	thrombin	48,56	heparin cofactor II	thrombin	3053	2147	Gene	Gene	accelerate|nmod|START_ENTITY accelerate|dobj|inhibition inhibition|nmod|END_ENTITY	Carboxylate polyanions accelerate inhibition of thrombin by heparin_cofactor_II .
3691797	0	heparin_cofactor_II	134,153	thrombin	122,130	heparin cofactor II	thrombin	3053	2147	Gene	Gene	essential|nmod|START_ENTITY essential|nmod|inhibition inhibition|nmod|END_ENTITY	Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin_cofactor_II .
3691797	0	heparin_cofactor_II	134,153	thrombin	42,50	heparin cofactor II	thrombin	3053	2147	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|Binding Binding|nmod|sulfate sulfate|nmod|END_ENTITY	Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin_cofactor_II .
7781777	0	heparin_cofactor_II	24,43	thrombin	76,84	heparin cofactor II	thrombin	100009170(Tax:9986)	100009146(Tax:9986)	Gene	Gene	mutagenesis|nmod|START_ENTITY mutagenesis|parataxis|defining defining|dobj|size size|nmod|serpin serpin|compound|END_ENTITY	Deletion mutagenesis of heparin_cofactor_II : defining the minimum size of a thrombin inhibiting serpin .
7974347	0	heparin_cofactor_II	43,62	thrombin	73,81	heparin cofactor II	thrombin	100009170(Tax:9986)	100009146(Tax:9986)	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|inhibitor inhibitor|compound|END_ENTITY	Molecular cloning and expression of rabbit heparin_cofactor_II : a plasma thrombin inhibitor highly conserved between species .
8792767	0	heparin_cofactor_II	92,111	thrombin	69,77	heparin cofactor II	thrombin	3053	2147	Gene	Gene	accelerate|nmod|START_ENTITY accelerate|dobj|inhibition inhibition|compound|END_ENTITY	Arterial smooth muscle cell heparan_sulfate proteoglycans accelerate thrombin inhibition by heparin_cofactor_II .
8995378	0	heparin_cofactor_II	103,122	thrombin	45,53	heparin cofactor II	thrombin	3053	2147	Gene	Gene	mutant|nmod|START_ENTITY END_ENTITY|nmod|mutant	Heparin promotes proteolytic inactivation by thrombin of a reactive site mutant -LRB- L444R -RRB- of recombinant heparin_cofactor_II .
9068899	0	heparin_cofactor_II	36,55	thrombin	13,21	heparin cofactor II	thrombin	3053	2147	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of thrombin inhibition by heparin_cofactor_II in the presence of dermatan sulphates , native or oversulphated , and a heparin-like dextran derivative .
9623718	0	heparin_cofactor_II	31,50	thrombin	60,68	heparin cofactor II	thrombin	79224(Tax:10116)	29251(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	Effects of dermatan_sulfate , a heparin_cofactor_II mediated thrombin inhibitor , on the endotoxin-induced disseminated_intravascular_coagulation model in the rat : comparison with low-molecular weight heparin , nafamostat_mesilate and argathroban .
19304666	0	hepassocin	139,149	HNF1alpha	104,113	hepassocin	HNF1alpha	2267	6927	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular_carcinoma .
19304666	0	hepassocin	38,48	HNF1alpha	104,113	hepassocin	HNF1alpha	2267	6927	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular_carcinoma .
19304666	0	hepassocin	139,149	hepassocin	38,48	hepassocin	hepassocin	2267	2267	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular_carcinoma .
19304666	0	hepassocin	38,48	hepassocin	139,149	hepassocin	hepassocin	2267	2267	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular_carcinoma .
26616280	0	hepatic_Flavin-containing_monooxygenase-3	89,130	FMO3	132,136	hepatic Flavin-containing monooxygenase-3	FMO3	2328	2328	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Oxidative stress-responsive transcription factor NRF2 is not indispensable for the human hepatic_Flavin-containing_monooxygenase-3 -LRB- FMO3 -RRB- gene expression in HepG2 cells .
7556072	0	hepatic_leukemia_factor	8,31	HLF	33,36	hepatic leukemia factor	HLF	690286(Tax:10116)	690286(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The rat hepatic_leukemia_factor -LRB- HLF -RRB- gene encodes two transcriptional activators with distinct circadian rhythms , tissue distributions and target preferences .
10944531	0	hepatic_lipase	49,63	Apolipoprotein_A-I	0,18	hepatic lipase	Apolipoprotein A-I	3990	335	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Apolipoprotein_A-I regulates lipid hydrolysis by hepatic_lipase .
15342685	0	hepatic_lipase	31,45	Farnesoid_X_receptor	0,20	hepatic lipase	Farnesoid X receptor	3990	9971	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Farnesoid_X_receptor represses hepatic_lipase gene expression .
2571126	0	hepatic_lipase	36,50	HL	52,54	hepatic lipase	HL	3990	3990	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Xmn-1 and Bg1-II RFLPs at the human hepatic_lipase -LRB- HL -RRB- gene locus .
20385826	0	hepatic_lipase	100,114	LIPC	121,125	hepatic lipase	LIPC	3990	3990	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genome-wide association study of advanced age-related_macular_degeneration identifies a role of the hepatic_lipase gene -LRB- LIPC -RRB- .
9469601	0	hepatic_lipase	128,142	LIPC	149,153	hepatic lipase	LIPC	3990	3990	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hepatic_lipase activity is lower in African American men than in white American men : effects of 5 ' flanking polymorphism in the hepatic_lipase gene -LRB- LIPC -RRB- .
9684756	0	hepatic_lipase	29,43	LIPC	50,54	hepatic lipase	LIPC	3990	3990	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The -514 polymorphism in the hepatic_lipase gene -LRB- LIPC -RRB- does not influence androgen-mediated stimulation of hepatic_lipase activity .
15721010	0	hepatic_lipase	90,104	Sterol-regulatory-element_binding_protein	0,41	hepatic lipase	Sterol-regulatory-element binding protein	3990	7555	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Sterol-regulatory-element_binding_protein inhibits upstream stimulatory factor-stimulated hepatic_lipase gene expression .
12796142	0	hepatic_lipase	20,34	apolipoprotein_A-I	157,175	hepatic lipase	apolipoprotein A-I	3990	100009253(Tax:9986)	Gene	Gene	Expression|nmod|START_ENTITY enhances|nsubj|Expression enhances|dobj|clearance clearance|nmod|triglyceride-enriched triglyceride-enriched|nmod|END_ENTITY	Expression of human hepatic_lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native high-density lipoprotein apolipoprotein_A-I .
2111173	0	hepatic_lipase	23,37	apolipoprotein_A-I	67,85	hepatic lipase	apolipoprotein A-I	100008678(Tax:9986)	100009253(Tax:9986)	Gene	Gene	Evidence|nmod|START_ENTITY reduces|nsubj|Evidence reduces|dobj|concentration concentration|nmod|END_ENTITY	Evidence in vitro that hepatic_lipase reduces the concentration of apolipoprotein_A-I in rabbit high-density lipoproteins .
25013403	0	hepatic_lipase	20,34	apolipoprotein_A-I	54,72	hepatic lipase	apolipoprotein A-I	3990	335	Gene	Gene	Expression|nmod|START_ENTITY impacts|nsubj|Expression impacts|dobj|production production|compound|END_ENTITY	Expression of human hepatic_lipase negatively impacts apolipoprotein_A-I production in primary hepatocytes from Lipc-null mice .
2036455	0	hepatic_lipase	14,28	apolipoprotein_E	73,89	hepatic lipase	apolipoprotein E	3990	348	Gene	Gene	Activation|nmod|START_ENTITY catalyzed|nsubj|Activation catalyzed|nmod|END_ENTITY	Activation of hepatic_lipase catalyzed phosphatidylcholine hydrolysis by apolipoprotein_E .
3591946	0	hepatic_lipase	65,79	apolipoprotein_E	13,29	hepatic lipase	apolipoprotein E	3990	348	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of apolipoprotein_E on soluble and heparin-immobilized hepatic_lipase .
10681408	0	hepatic_lipase	20,34	atherogenic_lipoprotein_phenotype	47,80	hepatic lipase	atherogenic lipoprotein phenotype	3990	470	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Contribution of the hepatic_lipase gene to the atherogenic_lipoprotein_phenotype in familial combined hyperlipidemia .
18662427	0	hepatic_lipase	160,174	cholesteryl_ester_transfer_protein	124,158	hepatic lipase	cholesteryl ester transfer protein	3990	1071	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Human fasting plasma concentrations of vitamin_E and carotenoids , and their association with genetic variants in apo C-III , cholesteryl_ester_transfer_protein , hepatic_lipase , intestinal fatty_acid binding protein and microsomal triacylglycerol transfer protein .
14564687	0	hepatic_lipase	101,115	lipoprotein_lipase	51,69	hepatic lipase	lipoprotein lipase	3990	4023	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	Interaction effect of Serine447Stop variant of the lipoprotein_lipase gene and C-514T variant of the hepatic_lipase gene on serum triglyceride levels in young adults : the Bogalusa Heart Study .
1657130	0	hepatic_lipase	125,139	lipoprotein_lipase	141,159	hepatic lipase	lipoprotein lipase	100008678(Tax:9986)	100340171(Tax:9986)	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Increased removal of beta-very low density lipoproteins after ethinyl_estradiol is associated with increased mRNA levels for hepatic_lipase , lipoprotein_lipase , and the low_density_lipoprotein_receptor in Watanabe_heritable_hyperlipidemic rabbits .
10393203	0	hepatic_lipase	50,64	scavenger_receptor_B-I	131,153	hepatic lipase	scavenger receptor B-I	3990	949	Gene	Gene	START_ENTITY|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Remodeling of HDL by CETP in vivo and by CETP and hepatic_lipase in vitro results in enhanced uptake of HDL CE by cells expressing scavenger_receptor_B-I .
9921275	0	hepatic_nuclear_factor-4	15,39	apolipoprotein_B	47,63	hepatic nuclear factor-4	apolipoprotein B	3172	338	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Association of hepatic_nuclear_factor-4 in the apolipoprotein_B promoter : a preliminary report .
11950391	0	hepatic_nuclear_factor_4alpha	45,74	glucokinase	14,25	hepatic nuclear factor 4alpha	glucokinase	25735(Tax:10116)	24385(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of glucokinase gene expression by hepatic_nuclear_factor_4alpha in primary hepatocytes .
9075616	0	hepatic_triglyceride_lipase	42,69	apolipoprotein_E	111,127	hepatic triglyceride lipase	apolipoprotein E	3990	348	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of estrogen replacement therapy on hepatic_triglyceride_lipase , lipoprotein_lipase and lipids including apolipoprotein_E in climacteric and elderly women .
17303008	0	hepatitis_B_X-interacting_protein	15,48	HBXIP	50,55	hepatitis B X-interacting protein	HBXIP	10542	10542	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of hepatitis_B_X-interacting_protein -LRB- HBXIP -RRB- in proliferation regulation of cells .
15683732	0	hepatocyte_growth_factor	38,62	Akt	75,78	hepatocyte growth factor	Akt	3082	207	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nmod|up-regulation up-regulation|amod|END_ENTITY	Trophoblast apoptosis is inhibited by hepatocyte_growth_factor through the Akt and beta-catenin mediated up-regulation of inducible_nitric_oxide_synthase .
24634221	0	hepatocyte_growth_factor	68,92	Akt	51,54	hepatocyte growth factor	Akt	3082	207	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Role of c-Met/phosphatidylinositol _ 3-kinase -LRB- PI3k -RRB- / Akt signaling in hepatocyte_growth_factor -LRB- HGF -RRB- - mediated lamellipodia formation , reactive oxygen species -LRB- ROS -RRB- generation , and motility of lung endothelial cells .
10800160	0	hepatocyte_growth_factor	8,32	CD34	76,80	hepatocyte growth factor	CD34	3082	947	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|cells cells|compound|END_ENTITY	Role of hepatocyte_growth_factor in the development of dendritic cells from CD34 + bone marrow cells .
8888500	0	hepatocyte_growth_factor	23,47	CD34	68,72	hepatocyte growth factor	CD34	3082	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Synergistic effects of hepatocyte_growth_factor on human cord blood CD34 + progenitor cells are the result of c-met receptor expression .
18829614	0	hepatocyte_growth_factor	56,80	CTGF	47,51	hepatocyte growth factor	CTGF	3082	1490	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of connective_tissue_growth_factor -LRB- CTGF -RRB- by hepatocyte_growth_factor in human tubular epithelial cells .
19692652	0	hepatocyte_growth_factor	74,98	EGFR	47,51	hepatocyte growth factor	EGFR	3082	1956	Gene	Gene	production|compound|START_ENTITY enhancing|dobj|production mediate|advcl|enhancing mediate|dobj|talk talk|nmod|END_ENTITY	MEK , p38 , and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte_growth_factor production from human mesenchymal stem cells .
20716641	0	hepatocyte_growth_factor	44,68	EGFR	167,171	hepatocyte growth factor	EGFR	3082	1956	Gene	Gene	antibody|nmod|START_ENTITY TAK-701|appos|antibody reverses|nsubj|TAK-701 reverses|dobj|resistance resistance|acl|induced induced|nmod|mutation mutation|amod|END_ENTITY	TAK-701 , a humanized monoclonal antibody to hepatocyte_growth_factor , reverses gefitinib resistance induced by tumor-derived HGF in non-small_cell_lung_cancer with an EGFR mutation .
12837293	0	hepatocyte_growth_factor	93,117	ERK1/2	83,89	hepatocyte growth factor	ERK1/2	3082	5595;5594	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of amyloid_precursor_protein expression and secretion via activation of ERK1/2 by hepatocyte_growth_factor in HEK293 cells transfected with APP751 .
11054808	0	hepatocyte_growth_factor	13,37	HGF	39,42	hepatocyte growth factor	HGF	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of hepatocyte_growth_factor -LRB- HGF -RRB- in rat microglial cells by prostaglandin_E -LRB- 2 -RRB- .
12573464	0	hepatocyte_growth_factor	24,48	HGF	50,53	hepatocyte growth factor	HGF	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Exogenous expression of hepatocyte_growth_factor -LRB- HGF -RRB- in rat striatum by naked plasmid DNA .
12784998	0	hepatocyte_growth_factor	9,33	HGF	35,38	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	activator|amod|START_ENTITY activator|appos|END_ENTITY	Roles of hepatocyte_growth_factor -LRB- HGF -RRB- activator and HGF_activator inhibitor in the pericellular activation of HGF/scatter factor .
14647442	0	hepatocyte_growth_factor	10,34	HGF	36,39	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human hepatocyte_growth_factor -LRB- HGF -RRB- gene is transcriptionally activated by leukemia_inhibitory_factor through the Stat binding element .
14675313	0	hepatocyte_growth_factor	19,43	HGF	14,17	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Comparison of HGF -LRB- hepatocyte_growth_factor -RRB- levels of epithelial_ovarian_cancer cyst fluids with benign ovarian_cysts .
15042617	0	hepatocyte_growth_factor	70,94	HGF	96,99	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Enhanced invasion of hormone refractory_prostate_cancer cells through hepatocyte_growth_factor -LRB- HGF -RRB- induction of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
1531136	0	hepatocyte_growth_factor	16,40	HGF	42,45	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of hepatocyte_growth_factor -LRB- HGF -RRB- gene on human chromosome 7 .
16116166	0	hepatocyte_growth_factor	36,60	HGF	62,65	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Follicular dendritic cells catalyze hepatocyte_growth_factor -LRB- HGF -RRB- activation in the germinal center microenvironment by secreting the serine protease HGF_activator .
16723436	0	hepatocyte_growth_factor	37,61	HGF	63,66	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Family-based association analysis of hepatocyte_growth_factor -LRB- HGF -RRB- gene polymorphisms in high_myopia .
19347810	0	hepatocyte_growth_factor	23,47	HGF	49,52	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	Serum concentration of hepatocyte_growth_factor -LRB- HGF -RRB- in oral_squamous_cell_carcinoma before and after surgery .
21897747	0	hepatocyte_growth_factor	19,43	HGF	45,48	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of hepatocyte_growth_factor -LRB- HGF -RRB- gene with primary angle_closure_glaucoma in the Nepalese population .
24142532	0	hepatocyte_growth_factor	31,55	HGF	57,60	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Clinical significance of serum hepatocyte_growth_factor -LRB- HGF -RRB- levels in hepatocellular_carcinoma .
7556648	0	hepatocyte_growth_factor	26,50	HGF	52,55	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Concomitant expression of hepatocyte_growth_factor -LRB- HGF -RRB- , HGF_activator and c-met genes in human glioma cells in vitro .
7590606	0	hepatocyte_growth_factor	15,39	HGF	41,44	hepatocyte growth factor	HGF	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of hepatocyte_growth_factor -LRB- HGF -RRB- in LEC rats at various phases of hepatitis and hepatoma -RSB- .
9223667	0	hepatocyte_growth_factor	34,58	HGF	60,63	hepatocyte growth factor	HGF	15234(Tax:10090)	15234(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the hepatocyte_growth_factor -LRB- HGF -RRB- gene by the Sp family of transcription factors .
9227267	0	hepatocyte_growth_factor	5,29	HGF	31,34	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Tear hepatocyte_growth_factor -LRB- HGF -RRB- availability increases markedly after excimer laser surface ablation .
9542659	0	hepatocyte_growth_factor	12,36	HGF	38,41	hepatocyte growth factor	HGF	15234(Tax:10090)	15234(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of hepatocyte_growth_factor -LRB- HGF -RRB- at progressive stages of metanephric development .
9804260	0	hepatocyte_growth_factor	31,55	HGF	57,60	hepatocyte growth factor	HGF	3082	3082	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Decreased maternal circulating hepatocyte_growth_factor -LRB- HGF -RRB- concentrations in pregnancies with small for gestational age infants .
9927158	0	hepatocyte_growth_factor	36,60	HGF	62,65	hepatocyte growth factor	HGF	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Hepatocyte-stimulated expression of hepatocyte_growth_factor -LRB- HGF -RRB- in cultured rat hepatic stellate cells .
15713485	0	hepatocyte_growth_factor	71,95	HGFA	107,111	hepatocyte growth factor	HGFA	3082	3083	Gene	Gene	activator|compound|START_ENTITY activator|appos|END_ENTITY	Conformational lability in serine_protease active sites : structures of hepatocyte_growth_factor activator -LRB- HGFA -RRB- alone and with the inhibitory domain from HGFA inhibitor-1B .
16005141	0	hepatocyte_growth_factor	6,30	HGFA	42,46	hepatocyte growth factor	HGFA	3082	3083	Gene	Gene	activator|compound|START_ENTITY activator|appos|END_ENTITY	Serum hepatocyte_growth_factor activator -LRB- HGFA -RRB- in benign_prostatic_hyperplasia and prostate_cancer .
21209281	0	hepatocyte_growth_factor	47,71	IL-7	42,46	hepatocyte growth factor	IL-7	15234(Tax:10090)	16196(Tax:10090)	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	In vivo administration of the recombinant IL-7 / hepatocyte_growth_factor b hybrid cytokine efficiently restores thymopoiesis and naive T cell generation in lethally irradiated mice after syngeneic bone marrow transplantation .
8725151	0	hepatocyte_growth_factor	61,85	LDL_receptor	14,26	hepatocyte growth factor	LDL receptor	3082	3949	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|compound|END_ENTITY	Activation of LDL_receptor gene expression in HepG2 cells by hepatocyte_growth_factor .
24790864	0	hepatocyte_growth_factor	11,35	MMP-2	39,44	hepatocyte growth factor	MMP-2	100730730	100719361	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of hepatocyte_growth_factor on MMP-2 expression in scleral fibroblasts from a guinea_pig myopia model .
15972796	0	hepatocyte_growth_factor	44,68	Matrix_metalloproteinase-1	0,26	hepatocyte growth factor	Matrix metalloproteinase-1	3082	4312	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Matrix_metalloproteinase-1 up-regulation by hepatocyte_growth_factor in human dermal fibroblasts via ERK signaling pathway involves Ets1 and Fli1 .
23657814	0	hepatocyte_growth_factor	51,75	Transforming_growth_factor-b1	0,29	hepatocyte growth factor	Transforming growth factor-b1	3082	7040	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-b1 selectively inhibits hepatocyte_growth_factor expression via a micro-RNA-199-dependent posttranscriptional mechanism .
9736044	0	hepatocyte_growth_factor	81,105	Transforming_growth_factor_alpha	0,32	hepatocyte growth factor	Transforming growth factor alpha	24446(Tax:10116)	24827(Tax:10116)	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|compound|END_ENTITY	Transforming_growth_factor_alpha levels in liver and blood correlate better than hepatocyte_growth_factor with hepatocyte proliferation during liver_regeneration .
19812386	0	hepatocyte_growth_factor	47,71	Urokinase-type_plasminogen_activator	0,36	hepatocyte growth factor	Urokinase-type plasminogen activator	15234(Tax:10090)	18792(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|END_ENTITY	Urokinase-type_plasminogen_activator increases hepatocyte_growth_factor activity required for skeletal muscle regeneration .
17534699	0	hepatocyte_growth_factor	10,34	XIAP	68,72	hepatocyte growth factor	XIAP	3082	331	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of hepatocyte_growth_factor -LRB- HGF -RRB- on the level of Survivin _ XIAP expression in several human cancer cell lines , after treating with DNA damaging agent .
12837293	0	hepatocyte_growth_factor	93,117	amyloid_precursor_protein	14,39	hepatocyte growth factor	amyloid precursor protein	3082	351	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of amyloid_precursor_protein expression and secretion via activation of ERK1/2 by hepatocyte_growth_factor in HEK293 cells transfected with APP751 .
10454454	0	hepatocyte_growth_factor	86,110	angiotensin_II	30,44	hepatocyte growth factor	angiotensin II	24446(Tax:10116)	24179(Tax:10116)	Gene	Gene	accompanied|nmod|START_ENTITY blockade|acl|accompanied blockade|amod|renal_damage renal_damage|nmod|END_ENTITY	Prevention of renal_damage by angiotensin_II blockade , accompanied by increased renal hepatocyte_growth_factor in experimental hypertensive rats .
10889138	0	hepatocyte_growth_factor	55,79	angiotensin_II	121,135	hepatocyte growth factor	angiotensin II	3082	183	Gene	Gene	factor|appos|START_ENTITY contribution|nmod|factor contribution|nmod|myocardial_fibrosis myocardial_fibrosis|nmod|blockade blockade|amod|END_ENTITY	Potential contribution of a novel antifibrotic factor , hepatocyte_growth_factor , to prevention of myocardial_fibrosis by angiotensin_II blockade in cardiomyopathic_hamsters .
12644877	0	hepatocyte_growth_factor	103,127	angiotensin_II	42,56	hepatocyte growth factor	angiotensin II	24446(Tax:10116)	24179(Tax:10116)	Gene	Gene	system|compound|START_ENTITY induction|nmod|system accompanied|nmod|induction accompanied|nsubj|Improvement Improvement|nmod|endothelial_dysfunction endothelial_dysfunction|nmod|blockade blockade|amod|END_ENTITY	Improvement of endothelial_dysfunction by angiotensin_II blockade accompanied by induction of vascular hepatocyte_growth_factor system in diabetic spontaneously hypertensive rats .
19713535	0	hepatocyte_growth_factor	19,43	angiotensin_II	60,74	hepatocyte growth factor	angiotensin II	15234(Tax:10090)	11606(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY action|dep|system system|nmod|signaling signaling|amod|END_ENTITY	Negative action of hepatocyte_growth_factor / c-Met system on angiotensin_II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells .
9403566	0	hepatocyte_growth_factor	72,96	angiotensin_II	8,22	hepatocyte growth factor	angiotensin II	24446(Tax:10116)	24179(Tax:10116)	Gene	Gene	modulator|appos|START_ENTITY regulation|nmod|modulator END_ENTITY|nmod|regulation	Role of angiotensin_II in the regulation of a novel vascular modulator , hepatocyte_growth_factor -LRB- HGF -RRB- , in experimental hypertensive rats .
9740609	0	hepatocyte_growth_factor	29,53	angiotensin_II	68,82	hepatocyte growth factor	angiotensin II	24446(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Negative regulation of local hepatocyte_growth_factor expression by angiotensin_II and transforming growth factor-beta in blood vessels : potential role of HGF in cardiovascular_disease .
24876152	0	hepatocyte_growth_factor	16,40	c-MET	41,46	hepatocyte growth factor	c-MET	3082	4233	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|amod|END_ENTITY	The role of the hepatocyte_growth_factor / c-MET pathway in pancreatic stellate cell-endothelial cell interactions : antiangiogenic implications in pancreatic_cancer .
25451235	0	hepatocyte_growth_factor	34,58	c-MET	71,76	hepatocyte growth factor	c-MET	3082	4233	Gene	Gene	fragment|nmod|START_ENTITY agonist|nsubj|fragment agonist|amod|END_ENTITY	An engineered dimeric fragment of hepatocyte_growth_factor is a potent c-MET agonist .
8180811	0	hepatocyte_growth_factor	40,64	c-MET	91,96	hepatocyte growth factor	c-MET	3082	4233	Gene	Gene	antibodies|nmod|START_ENTITY Immunohistochemistry|nmod|antibodies protein|amod|Immunohistochemistry protein|appos|END_ENTITY	Immunohistochemistry with antibodies to hepatocyte_growth_factor and its receptor protein -LRB- c-MET -RRB- in human brain tissues .
10642827	0	hepatocyte_growth_factor	27,51	c-Met	70,75	hepatocyte growth factor	c-Met	24446(Tax:10116)	24553(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of hepatocyte_growth_factor and its receptor , c-Met in the rat retina during development .
11328532	0	hepatocyte_growth_factor	18,42	c-Met	43,48	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|increased increased|nsubjpass|pathway pathway|amod|END_ENTITY	Expression of the hepatocyte_growth_factor / c-Met pathway is increased at the cancer front in breast_carcinoma .
11735009	0	hepatocyte_growth_factor	22,46	c-Met	65,70	hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of hepatocyte_growth_factor and its receptor -LRB- c-Met -RRB- during mouse liver development .
14730703	0	hepatocyte_growth_factor	17,41	c-Met	42,47	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|loop loop|amod|END_ENTITY	CD44-independent hepatocyte_growth_factor / c-Met autocrine loop promotes malignant_peripheral_nerve_sheath_tumor cell invasion in vitro .
15075332	0	hepatocyte_growth_factor	167,191	c-Met	119,124	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	involves|nmod|START_ENTITY involves|dobj|activation activation|amod|END_ENTITY	Bi-directional regulation of Ser-985 phosphorylation of c-met via protein_kinase_C and protein phosphatase_2A involves c-Met activation and cellular responsiveness to hepatocyte_growth_factor .
15288476	0	hepatocyte_growth_factor	32,56	c-Met	67,72	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	SU5416 is a potent inhibitor of hepatocyte_growth_factor receptor -LRB- c-Met -RRB- and blocks HGF-induced invasiveness of human HepG2 hepatoma cells .
15842800	0	hepatocyte_growth_factor	15,39	c-Met	40,45	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|system system|amod|END_ENTITY	-LSB- Expression of hepatocyte_growth_factor / c-Met system in nasopharyngeal_carcinoma and its biological significance -RSB- .
16998831	0	hepatocyte_growth_factor	111,135	c-Met	136,141	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	cells|nmod|START_ENTITY invasiveness|nmod|cells pathway|dep|invasiveness pathway|amod|END_ENTITY	Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic_cancer cells through the hepatocyte_growth_factor / c-Met pathway .
17534684	0	hepatocyte_growth_factor	121,145	c-Met	146,151	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	activation|nmod|START_ENTITY progression|nmod|activation accelerates|dobj|progression END_ENTITY|dep|accelerates	The hypoxic environment in tumor-stromal cells accelerates pancreatic_cancer progression via the activation of paracrine hepatocyte_growth_factor / c-Met signaling .
17942915	0	hepatocyte_growth_factor	8,32	c-Met	33,38	hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY Loss|parataxis|accelerates accelerates|nsubj|signaling signaling|amod|END_ENTITY	Loss of hepatocyte_growth_factor / c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis .
17992475	0	hepatocyte_growth_factor	8,32	c-Met	33,38	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|signaling signaling|nsubj|END_ENTITY	Role of hepatocyte_growth_factor / c-Met signaling in regulating urokinase plasminogen activator on invasiveness_in_human_hepatocellular_carcinoma : a potential therapeutic target .
18422749	0	hepatocyte_growth_factor	13,37	c-Met	117,122	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression activates|nsubj|Induction activates|parataxis|factor-1 factor-1|dep|system system|amod|END_ENTITY	Induction of hepatocyte_growth_factor activator gene expression under hypoxia activates the hepatocyte_growth_factor / c-Met system via hypoxia inducible factor-1 in pancreatic_cancer .
18422749	0	hepatocyte_growth_factor	92,116	c-Met	117,122	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	activates|dobj|START_ENTITY activates|parataxis|factor-1 factor-1|dep|system system|amod|END_ENTITY	Induction of hepatocyte_growth_factor activator gene expression under hypoxia activates the hepatocyte_growth_factor / c-Met system via hypoxia inducible factor-1 in pancreatic_cancer .
19123972	0	hepatocyte_growth_factor	4,28	c-Met	29,34	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	The hepatocyte_growth_factor / c-Met signaling pathway as a therapeutic target to inhibit angiogenesis .
19435874	0	hepatocyte_growth_factor	71,95	c-Met	51,56	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte_growth_factor : c-Met-dependent tumors in animal models .
19435874	0	hepatocyte_growth_factor	71,95	c-Met	8,13	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	phosphorylation|nmod|START_ENTITY inhibit|dobj|phosphorylation inhibit|nsubj|receptors receptors|amod|END_ENTITY	Soluble c-Met receptors inhibit phosphorylation of c-Met and growth of hepatocyte_growth_factor : c-Met-dependent tumors in animal models .
19713535	0	hepatocyte_growth_factor	19,43	c-Met	44,49	hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY action|dep|system system|amod|END_ENTITY	Negative action of hepatocyte_growth_factor / c-Met system on angiotensin_II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells .
20086056	0	hepatocyte_growth_factor	91,115	c-Met	116,121	hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	act|nmod|START_ENTITY Nle-Tyr-Leu-psi|parataxis|act Nle-Tyr-Leu-psi|dobj|inhibitor inhibitor|amod|END_ENTITY	The angiotensin_IV analog Nle-Tyr-Leu-psi - -LRB- CH2-NH2 -RRB- 3-4-His-Pro-Phe -LRB- norleual -RRB- can act as a hepatocyte_growth_factor / c-Met inhibitor .
20178463	0	hepatocyte_growth_factor	5,29	c-Met	30,35	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	signal|compound|START_ENTITY signal|amod|END_ENTITY	Does hepatocyte_growth_factor / c-Met signal play synergetic role in lung_cancer ?
20819464	0	hepatocyte_growth_factor	12,36	c-Met	37,42	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of hepatocyte_growth_factor / c-Met in chronic rhinosinusitis with nasal_polyps .
20980460	0	hepatocyte_growth_factor	14,38	c-Met	39,44	hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	Disruption|nmod|START_ENTITY Disruption|parataxis|enhances enhances|nsubj|signaling signaling|amod|END_ENTITY	Disruption of hepatocyte_growth_factor / c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes .
21150524	0	hepatocyte_growth_factor	12,36	c-Met	37,42	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	role|nmod|START_ENTITY role|dep|system system|amod|END_ENTITY	The role of hepatocyte_growth_factor / c-Met system in keloid pathogenesis .
21796631	0	hepatocyte_growth_factor	111,135	c-Met	136,141	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	established|nmod|START_ENTITY dissemination|acl|established predicts|dobj|dissemination END_ENTITY|dep|predicts	Co-expression of hepatocyte_growth_factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte_growth_factor / c-Met signaling in gastric_cancer .
21796631	0	hepatocyte_growth_factor	17,41	c-Met	136,141	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	Co-expression|nmod|START_ENTITY predicts|nsubj|Co-expression END_ENTITY|dep|predicts	Co-expression of hepatocyte_growth_factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte_growth_factor / c-Met signaling in gastric_cancer .
22996389	0	hepatocyte_growth_factor	80,104	c-Met	16,21	hepatocyte growth factor	c-Met	15234(Tax:10090)	4233	Gene	Gene	response|nmod|START_ENTITY cells|nmod|response sites|nmod|cells sites|amod|END_ENTITY	Dissociation of c-Met phosphotyrosine sites in human cells in response to mouse hepatocyte_growth_factor but not human hepatocyte_growth_factor : the possible roles of different amino_acids in different species .
24609899	0	hepatocyte_growth_factor	21,45	c-Met	46,51	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	miR-199a-3p inhibits hepatocyte_growth_factor / c-Met signaling in renal_cancer_carcinoma .
24748602	0	hepatocyte_growth_factor	85,109	c-Met	110,115	hepatocyte growth factor	c-Met	24446(Tax:10116)	4233	Gene	Gene	accelerate|nmod|START_ENTITY fibroblasts|xcomp|accelerate END_ENTITY|dep|fibroblasts	Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte_growth_factor / c-Met signaling .
24810547	0	hepatocyte_growth_factor	9,33	c-Met	70,75	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|gene gene|amod|END_ENTITY	Frequent hepatocyte_growth_factor overexpression and low frequency of c-Met gene amplification in human_papillomavirus-negative tonsillar_squamous_cell_carcinoma and their prognostic significances .
25592281	0	hepatocyte_growth_factor	25,49	c-Met	50,55	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	significance|nmod|START_ENTITY significance|dep|expression expression|amod|END_ENTITY	Clinical significance of hepatocyte_growth_factor / c-Met expression in the assessment of gastric_cancer progression .
9184586	0	hepatocyte_growth_factor	23,47	c-Met	48,53	hepatocyte growth factor	c-Met	24446(Tax:10116)	24553(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Enhanced expression of hepatocyte_growth_factor / c-Met by myocardial_ischemia and reperfusion in a rat model .
9600310	0	hepatocyte_growth_factor	49,73	c-Met	27,32	hepatocyte growth factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY Expression|appos|receptor Expression|nmod|END_ENTITY	Expression and function of c-Met , a receptor for hepatocyte_growth_factor , during T-cell development .
9722511	0	hepatocyte_growth_factor	58,82	c-Met	86,91	hepatocyte growth factor	c-Met	3082	4233	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Cooperative interaction between alpha - and beta-chains of hepatocyte_growth_factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses .
10713700	0	hepatocyte_growth_factor	34,58	c-met	69,74	hepatocyte growth factor	c-met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the hepatocyte_growth_factor receptor -LRB- c-met -RRB- gene by its ligand -LRB- hepatocyte_growth_factor -RRB- is mediated through AP-1 .
10713700	0	hepatocyte_growth_factor	96,120	c-met	69,74	hepatocyte growth factor	c-met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the hepatocyte_growth_factor receptor -LRB- c-met -RRB- gene by its ligand -LRB- hepatocyte_growth_factor -RRB- is mediated through AP-1 .
12042032	0	hepatocyte_growth_factor	30,54	c-met	75,80	hepatocyte growth factor	c-met	24446(Tax:10116)	24553(Tax:10116)	Gene	Gene	chain|nmod|START_ENTITY Increase|nmod|chain precedes|nsubj|Increase precedes|dobj|expression expression|amod|END_ENTITY	Increase in the beta chain of hepatocyte_growth_factor -LRB- HGF beta -RRB- precedes c-met expression after bleomycin-induced lung_injury in the rat .
12847110	0	hepatocyte_growth_factor	25,49	c-met	138,143	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	domain|nmod|START_ENTITY inhibits|nsubj|domain inhibits|advmod|independently independently|advcl|binding binding|nmod|receptor receptor|amod|END_ENTITY	The N-terminal domain of hepatocyte_growth_factor inhibits the angiogenic behavior of endothelial cells independently from binding to the c-met receptor .
14626426	0	hepatocyte_growth_factor	12,36	c-met	37,42	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	role|nmod|START_ENTITY role|dep|interactions interactions|amod|END_ENTITY	The role of hepatocyte_growth_factor / c-met interactions in the immune system .
15075332	0	hepatocyte_growth_factor	167,191	c-met	56,61	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	involves|nmod|START_ENTITY involves|nsubj|regulation regulation|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Bi-directional regulation of Ser-985 phosphorylation of c-met via protein_kinase_C and protein phosphatase_2A involves c-Met activation and cellular responsiveness to hepatocyte_growth_factor .
15475459	0	hepatocyte_growth_factor	48,72	c-met	12,17	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	loop|compound|START_ENTITY blocks|dobj|loop blocks|nsubj|inhibitor inhibitor|amod|END_ENTITY	A selective c-met inhibitor blocks an autocrine hepatocyte_growth_factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells .
16144866	0	hepatocyte_growth_factor	73,97	c-met	98,103	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte_growth_factor / c-met axis .
17940345	0	hepatocyte_growth_factor	93,117	c-met	118,123	hepatocyte growth factor	c-met	24446(Tax:10116)	24553(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Attenuation|dep|role Attenuation|dep|axis axis|amod|END_ENTITY	Attenuation of glycerol-induced acute_kidney_injury by previous partial hepatectomy : role of hepatocyte_growth_factor / c-met axis in tubular protection .
1846706	0	hepatocyte_growth_factor	22,46	c-met	63,68	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	receptor|compound|START_ENTITY Identification|nmod|receptor Identification|nmod|product product|amod|END_ENTITY	Identification of the hepatocyte_growth_factor receptor as the c-met proto-oncogene product .
23715119	0	hepatocyte_growth_factor	14,38	c-met	49,54	hepatocyte growth factor	c-met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Activation of hepatocyte_growth_factor receptor , c-met , in renal tubules is required for renoprotection after acute_kidney_injury .
24052949	0	hepatocyte_growth_factor	102,126	c-met	127,132	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	expansion|nmod|START_ENTITY expansion|dep|END_ENTITY	Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte_growth_factor / c-met and STAT3 .
25187433	0	hepatocyte_growth_factor	112,136	c-met	137,142	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	The procognitive and synaptogenic effects of angiotensin_IV-derived peptides are dependent on activation of the hepatocyte_growth_factor / c-met system .
8067383	0	hepatocyte_growth_factor	23,47	c-met	48,53	hepatocyte growth factor	c-met	24446(Tax:10116)	24553(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Regional expression of hepatocyte_growth_factor / c-met in experimental renal_hypertrophy and hyperplasia .
8640940	0	hepatocyte_growth_factor	81,105	c-met	106,111	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY transforming_growth_factor_alpha|dep|epidermal_growth_factor_receptor transforming_growth_factor_alpha|amod|END_ENTITY	Expression of transforming_growth_factor_alpha / epidermal_growth_factor_receptor , hepatocyte_growth_factor / c-met and acidic_fibroblast_growth_factor / fibroblast growth factor receptors during hepatocarcinogenesis .
8707284	0	hepatocyte_growth_factor	6,30	c-met	137,142	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	correlate|nsubj|START_ENTITY correlate|parataxis|does does|nsubj|END_ENTITY	Liver hepatocyte_growth_factor does not always correlate with hepatocellular proliferation in human liver lesions : its specific receptor c-met does .
8888500	0	hepatocyte_growth_factor	23,47	c-met	109,114	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	cells|amod|START_ENTITY effects|nmod|cells result|nsubj|effects result|nmod|expression expression|amod|END_ENTITY	Synergistic effects of hepatocyte_growth_factor on human cord blood CD34 + progenitor cells are the result of c-met receptor expression .
9049208	0	hepatocyte_growth_factor	14,38	c-met	61,66	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|proto-oncogene proto-oncogene|amod|END_ENTITY	Expression of hepatocyte_growth_factor and its receptor , the c-met proto-oncogene , in_hepatocellular_carcinoma .
9142219	0	hepatocyte_growth_factor	21,45	c-met	46,51	hepatocyte growth factor	c-met	24446(Tax:10116)	24553(Tax:10116)	Gene	Gene	Modifications|nmod|START_ENTITY Modifications|dep|pathway pathway|amod|END_ENTITY	Modifications of the hepatocyte_growth_factor / c-met pathway by constitutive expression of transforming_growth_factor-alpha in rat liver epithelial cells .
9211490	0	hepatocyte_growth_factor	53,77	c-met	0,5	hepatocyte growth factor	c-met	3082	4233	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	c-met expression in pancreatic_cancer and effects of hepatocyte_growth_factor on pancreatic_cancer cell growth .
18829614	0	hepatocyte_growth_factor	56,80	connective_tissue_growth_factor	14,45	hepatocyte growth factor	connective tissue growth factor	3082	1490	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of connective_tissue_growth_factor -LRB- CTGF -RRB- by hepatocyte_growth_factor in human tubular epithelial cells .
14751415	0	hepatocyte_growth_factor	64,88	cyclooxygenase-2	14,30	hepatocyte growth factor	cyclooxygenase-2	24446(Tax:10116)	29527(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY reduces|dobj|effect reduces|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte_growth_factor in experimental pancreatitis .
17550984	0	hepatocyte_growth_factor	61,85	cyclooxygenase-2	31,47	hepatocyte growth factor	cyclooxygenase-2	3082	5743	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|induction induction|amod|END_ENTITY	Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte_growth_factor in non_small-cell_lung_cancer .
21687953	0	hepatocyte_growth_factor	64,88	cyclooxygenase-2	30,46	hepatocyte growth factor	cyclooxygenase-2	3082	5743	Gene	Gene	involved|nmod|START_ENTITY involved|nmod|up-regulation up-regulation|amod|END_ENTITY	Signaling pathway involved in cyclooxygenase-2 up-regulation by hepatocyte_growth_factor in endometrial_cancer cells .
18242595	0	hepatocyte_growth_factor	22,46	eNOS	62,66	hepatocyte growth factor	eNOS	3082	4846	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Geldanamycin enhances hepatocyte_growth_factor stimulation of eNOS phosphorylation in endothelial cells .
7534491	0	hepatocyte_growth_factor	13,37	epidermal_growth_factor	67,90	hepatocyte growth factor	epidermal growth factor	24446(Tax:10116)	1950	Gene	Gene	Induction|nmod|START_ENTITY fibroblasts|nsubj|Induction fibroblasts|nmod|END_ENTITY	Induction of hepatocyte_growth_factor in human skin fibroblasts by epidermal_growth_factor , platelet-derived growth factor and fibroblast growth factor .
18234969	0	hepatocyte_growth_factor	71,95	epidermal_growth_factor_receptor	24,56	hepatocyte growth factor	epidermal growth factor receptor	3082	1956	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Transcription-dependent epidermal_growth_factor_receptor activation by hepatocyte_growth_factor .
16174451	0	hepatocyte_growth_factor	100,124	fibroblast_growth_factor-4	130,156	hepatocyte growth factor	fibroblast growth factor-4	3082	2249	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Human bone marrow multipotent adult progenitor cells differentiate into hepatocyte-like cells with hepatocyte_growth_factor plus fibroblast_growth_factor-4 in vitro -RSB- .
10544272	0	hepatocyte_growth_factor	53,77	gamma-glutamylcysteine_synthetase	95,128	hepatocyte growth factor	gamma-glutamylcysteine synthetase	24446(Tax:10116)	25283(Tax:10116)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Elevation of glutathione level in rat hepatocytes by hepatocyte_growth_factor via induction of gamma-glutamylcysteine_synthetase .
10713700	0	hepatocyte_growth_factor	34,58	hepatocyte_growth_factor	96,120	hepatocyte growth factor	hepatocyte growth factor	15234(Tax:10090)	15234(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the hepatocyte_growth_factor receptor -LRB- c-met -RRB- gene by its ligand -LRB- hepatocyte_growth_factor -RRB- is mediated through AP-1 .
10713700	0	hepatocyte_growth_factor	96,120	hepatocyte_growth_factor	34,58	hepatocyte growth factor	hepatocyte growth factor	15234(Tax:10090)	15234(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional activation of the hepatocyte_growth_factor receptor -LRB- c-met -RRB- gene by its ligand -LRB- hepatocyte_growth_factor -RRB- is mediated through AP-1 .
18979225	0	hepatocyte_growth_factor	17,41	hypoxia-inducible_factor_1	50,76	hepatocyte growth factor	hypoxia-inducible factor 1	3082	3091	Gene	Gene	mRNA|compound|START_ENTITY Stabilization|nmod|mRNA Stabilization|nmod|END_ENTITY	Stabilization of hepatocyte_growth_factor mRNA by hypoxia-inducible_factor_1 .
15541342	0	hepatocyte_growth_factor	14,38	interferon-gamma	116,132	hepatocyte growth factor	interferon-gamma	3082	3458	Gene	Gene	Inhibition|nmod|START_ENTITY induction|nsubj|Inhibition induction|nmod|END_ENTITY	Inhibition of hepatocyte_growth_factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma .
1384479	0	hepatocyte_growth_factor	17,41	interleukin-1	61,74	hepatocyte growth factor	interleukin-1	3082	3552	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of hepatocyte_growth_factor gene expression by interleukin-1 in human skin fibroblasts .
15541342	0	hepatocyte_growth_factor	14,38	interleukin-1	80,93	hepatocyte growth factor	interleukin-1	3082	3552	Gene	Gene	Inhibition|nmod|START_ENTITY induction|nsubj|Inhibition induction|nmod|END_ENTITY	Inhibition of hepatocyte_growth_factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma .
15629451	0	hepatocyte_growth_factor	25,49	interleukin-1_and_interferon-gamma	106,140	hepatocyte growth factor	interleukin-1 and interferon-gamma	3082	3552;3458	Gene	Gene	induction|nmod|START_ENTITY fibroblasts|nsubj|induction fibroblasts|nmod|END_ENTITY	Synergistic induction of hepatocyte_growth_factor in human skin fibroblasts by the inflammatory cytokines interleukin-1_and_interferon-gamma .
15627638	0	hepatocyte_growth_factor	29,53	interleukin-1_receptor_antagonist	68,101	hepatocyte growth factor	interleukin-1 receptor antagonist	3082	3557	Gene	Gene	effects|nmod|START_ENTITY effects|dep|induction induction|nmod|END_ENTITY	Anti-inflammatory effects of hepatocyte_growth_factor : induction of interleukin-1_receptor_antagonist .
11322204	0	hepatocyte_growth_factor	18,42	interleukin-6	74,87	hepatocyte growth factor	interleukin-6	3082	3569	Gene	Gene	response|nmod|START_ENTITY treated|nsubj|response treated|nsubj|proteins proteins|amod|END_ENTITY	Serum response of hepatocyte_growth_factor , insulin-like_growth_factor-I , interleukin-6 , and acute phase proteins in patients with colorectal_liver_metastases treated with partial hepatectomy or cryosurgery .
11424323	0	hepatocyte_growth_factor	40,64	interleukin-6	18,31	hepatocyte growth factor	interleukin-6	3082	3569	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Recombinant human interleukin-6 induces hepatocyte_growth_factor production in cancer patients .
12174163	0	hepatocyte_growth_factor	48,72	interleukin-6	15,28	hepatocyte growth factor	interleukin-6	3082	3569	Gene	Gene	Association|nmod|START_ENTITY Association|acl|END_ENTITY	Association of interleukin-6 and estradiol with hepatocyte_growth_factor in peritoneal fluid of women with endometriosis .
8910300	0	hepatocyte_growth_factor	129,153	lipocortin-1	73,85	hepatocyte growth factor	lipocortin-1	3082	301	Gene	Gene	signal|nmod|START_ENTITY transduces|dobj|signal transduces|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	The hepatocyte_growth_factor receptor kinase-mediated phosphorylation of lipocortin-1 transduces the proliferating signal of the hepatocyte_growth_factor .
8910300	0	hepatocyte_growth_factor	4,28	lipocortin-1	73,85	hepatocyte growth factor	lipocortin-1	3082	301	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	The hepatocyte_growth_factor receptor kinase-mediated phosphorylation of lipocortin-1 transduces the proliferating signal of the hepatocyte_growth_factor .
11830493	0	hepatocyte_growth_factor	46,70	syndecan-1	26,36	hepatocyte growth factor	syndecan-1	3082	6382	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Cell surface proteoglycan syndecan-1 mediates hepatocyte_growth_factor binding and promotes Met signaling in multiple_myeloma .
11421874	0	hepatocyte_growth_factor	14,38	transforming_growth_factor_alpha	40,72	hepatocyte growth factor	transforming growth factor alpha	3082	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of hepatocyte_growth_factor , transforming_growth_factor_alpha , apoptosis related proteins Bax and Bcl-2 , and gastrin in human gastric_cancer .
8640940	0	hepatocyte_growth_factor	81,105	transforming_growth_factor_alpha	14,46	hepatocyte growth factor	transforming growth factor alpha	3082	7124	Gene	Gene	epidermal_growth_factor_receptor|appos|START_ENTITY END_ENTITY|dep|epidermal_growth_factor_receptor	Expression of transforming_growth_factor_alpha / epidermal_growth_factor_receptor , hepatocyte_growth_factor / c-met and acidic_fibroblast_growth_factor / fibroblast growth factor receptors during hepatocarcinogenesis .
15042617	0	hepatocyte_growth_factor	70,94	urokinase-type_plasminogen_activator	114,150	hepatocyte growth factor	urokinase-type plasminogen activator	3082	5328	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Enhanced invasion of hormone refractory_prostate_cancer cells through hepatocyte_growth_factor -LRB- HGF -RRB- induction of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
11954744	0	hepatocyte_growth_factor	6,30	vascular_endothelial_growth_factor	45,79	hepatocyte growth factor	vascular endothelial growth factor	3082	7422	Gene	Gene	combined|nsubj|START_ENTITY combined|nmod|END_ENTITY	Serum hepatocyte_growth_factor combined with vascular_endothelial_growth_factor as a predictive indicator for the occurrence of coronary_artery_lesions in Kawasaki_disease .
12021262	0	hepatocyte_growth_factor-regulated_tyrosine_kinase_substrate	47,107	Huntingtin-associated_protein_1	0,31	hepatocyte growth factor-regulated tyrosine kinase substrate	Huntingtin-associated protein 1	9146	9001	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Huntingtin-associated_protein_1 interacts with hepatocyte_growth_factor-regulated_tyrosine_kinase_substrate and functions in endosomal trafficking .
16106403	0	hepatocyte_growth_factor_activator	8,42	HGF_activator	44,57	hepatocyte growth factor activator	HGF activator	3083	3083	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of hepatocyte_growth_factor_activator -LRB- HGF_activator -RRB- in invasive growth of human glioblastoma cells in vivo .
19578736	0	hepatocyte_growth_factor_activator_inhibitor-1	12,58	HAI-1	60,65	hepatocyte growth factor activator inhibitor-1	HAI-1	6692	6692	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of hepatocyte_growth_factor_activator_inhibitor-1 -LRB- HAI-1 -RRB- as a prognostic indicator in cervical_cancer .
16983341	0	hepatocyte_growth_factor_activator_inhibitor-1	25,71	Matriptase	0,10	hepatocyte growth factor activator inhibitor-1	Matriptase	20732(Tax:10090)	19143(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Matriptase inhibition by hepatocyte_growth_factor_activator_inhibitor-1 is essential for placental development .
10695988	0	hepatocyte_growth_factor_activator_inhibitor_type-2	24,75	placental_bikunin	76,93	hepatocyte growth factor activator inhibitor type-2	placental bikunin	10653	10653	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Conserved expression of hepatocyte_growth_factor_activator_inhibitor_type-2 / placental_bikunin in human colorectal_carcinomas .
10219059	0	hepatocyte_growth_factor_activator_inhibitor_type_1	16,67	HAI-1	69,74	hepatocyte growth factor activator inhibitor type 1	HAI-1	6692	6692	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of hepatocyte_growth_factor_activator_inhibitor_type_1 -LRB- HAI-1 -RRB- in human tissues .
18048349	0	hepatocyte_growth_factor_activator_inhibitor_type_1	46,97	matriptase	119,129	hepatocyte growth factor activator inhibitor type 1	matriptase	311331(Tax:10116)	114093(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Roles of functional and structural domains of hepatocyte_growth_factor_activator_inhibitor_type_1 in the inhibition of matriptase .
15930277	0	hepatocyte_growth_factor_activator_inhibitor_type_2	57,108	SPINT2	109,115	hepatocyte growth factor activator inhibitor type 2	SPINT2	10653	10653	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Tumor suppressor activity and epigenetic inactivation of hepatocyte_growth_factor_activator_inhibitor_type_2 / SPINT2 in papillary and clear_cell_renal_cell_carcinoma .
12161522	0	hepatocyte_nuclear_factor-1_beta	45,77	TCF2	84,88	hepatocyte nuclear factor-1 beta	TCF2	6928	6928	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nonsense and missense mutations in the human hepatocyte_nuclear_factor-1_beta gene -LRB- TCF2 -RRB- and their relation to type 2 diabetes in Japanese .
20633866	0	hepatocyte_nuclear_factor-1b	17,45	HNF1B	47,52	hepatocyte nuclear factor-1b	HNF1B	6928	6928	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the hepatocyte_nuclear_factor-1b -LRB- HNF1B -RRB- gene are common with combined uterine and renal malformations but are not found with isolated uterine malformations .
21617276	0	hepatocyte_nuclear_factor-1b	8,36	MODY_5	38,44	hepatocyte nuclear factor-1b	MODY 5	6928	6928	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A novel hepatocyte_nuclear_factor-1b -LRB- MODY_5 -RRB- gene mutation in a Romanian boy with pancreatic_calcifications , _ renal_and_hepatic_dysfunction .
23657850	0	hepatocyte_nuclear_factor-1b	74,102	Zyxin	0,5	hepatocyte nuclear factor-1b	Zyxin	6928	7791	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Zyxin regulates migration of renal epithelial cells through activation of hepatocyte_nuclear_factor-1b .
15647252	0	hepatocyte_nuclear_factor-1beta	12,43	HNF-1beta	45,54	hepatocyte nuclear factor-1beta	HNF-1beta	21410(Tax:10090)	21410(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Role of the hepatocyte_nuclear_factor-1beta -LRB- HNF-1beta -RRB- C-terminal domain in Pkhd1 -LRB- ARPKD -RRB- gene transcription and renal cystogenesis .
17307554	0	hepatocyte_nuclear_factor-1beta	72,103	HNF-1beta	110,119	hepatocyte nuclear factor-1beta	HNF-1beta	6928	6928	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Neonatal cholestatic_jaundice as the first symptom of a mutation in the hepatocyte_nuclear_factor-1beta gene -LRB- HNF-1beta -RRB- .
16249435	0	hepatocyte_nuclear_factor-1beta	36,67	TCF2	69,73	hepatocyte nuclear factor-1beta	TCF2	6928	6928	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Large genomic rearrangements in the hepatocyte_nuclear_factor-1beta -LRB- TCF2 -RRB- gene are the most frequent cause of maturity-onset diabetes_of_the_young_type_5 .
10868948	0	hepatocyte_nuclear_factor-3beta	99,130	HNF3B	137,142	hepatocyte nuclear factor-3beta	HNF3B	3170	3170	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Beta-cell transcription factors and diabetes : no evidence for diabetes-associated mutations in the hepatocyte_nuclear_factor-3beta gene -LRB- HNF3B -RRB- in Japanese patients with maturity-onset diabetes_of_the_young .
10868949	0	hepatocyte_nuclear_factor-3beta	25,56	HNF3B	63,68	hepatocyte nuclear factor-3beta	HNF3B	3170	3170	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the hepatocyte_nuclear_factor-3beta gene -LRB- HNF3B -RRB- does not contribute to maturity-onset_diabetes_of_the_young in French Caucasians .
14530276	0	hepatocyte_nuclear_factor-4_alpha	69,102	Acyl-CoA-binding_protein	39,63	hepatocyte nuclear factor-4 alpha	Acyl-CoA-binding protein	25735(Tax:10116)	25045(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of Acyl-CoA-binding_protein with hepatocyte_nuclear_factor-4_alpha .
21047794	0	hepatocyte_nuclear_factor-4a	29,57	HNF4a	59,64	hepatocyte nuclear factor-4a	HNF4a	3172	3172	Gene	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	Proteomic analysis of native hepatocyte_nuclear_factor-4a -LRB- HNF4a -RRB- isoforms , phosphorylation status , and interactive cofactors .
20621834	0	hepatocyte_nuclear_factor-4alpha	8,40	C1qTNF-related_protein_5	74,98	hepatocyte nuclear factor-4alpha	C1qTNF-related protein 5	3172	114902	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of hepatocyte_nuclear_factor-4alpha in transcriptional regulation of C1qTNF-related_protein_5 in the liver .
9294105	0	hepatocyte_nuclear_factor-4alpha	69,101	MODY1	102,107	hepatocyte nuclear factor-4alpha	MODY1	3172	3172	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Hepatic function in a family with a nonsense mutation -LRB- R154X -RRB- in the hepatocyte_nuclear_factor-4alpha / MODY1 gene .
9356021	0	hepatocyte_nuclear_factor-4alpha	111,143	MODY1	144,149	hepatocyte nuclear factor-4alpha	MODY1	3172	3172	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte_nuclear_factor-4alpha / MODY1 gene .
17603092	0	hepatocyte_nuclear_factor-4alpha	89,121	p38_mitogen-activated_protein_kinase	44,80	hepatocyte nuclear factor-4alpha	p38 mitogen-activated protein kinase	3172	1432	Gene	Gene	phosphorylation|amod|START_ENTITY END_ENTITY|dep|phosphorylation	Activation of bile_acid biosynthesis by the p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- : hepatocyte_nuclear_factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol_7alpha-hydroxylase expression .
15381696	0	hepatocyte_nuclear_factor-6	25,52	Onecut-1	53,61	hepatocyte nuclear factor-6	Onecut-1	15379(Tax:10090)	15379(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|controls controls|nsubj|END_ENTITY	The transcription factor hepatocyte_nuclear_factor-6 / Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm .
7881411	0	hepatocyte_nuclear_factor_1	33,60	protein_C	68,77	hepatocyte nuclear factor 1	protein C	6927	5624	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Disruption of a binding site for hepatocyte_nuclear_factor_1 in the protein_C gene promoter is associated with hereditary_thrombophilia .
23052196	0	hepatocyte_nuclear_factor_1_and_4_alpha	14,53	HNF1a	55,60	hepatocyte nuclear factor 1 and 4 alpha	HNF1a	3172	6927	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition of hepatocyte_nuclear_factor_1_and_4_alpha -LRB- HNF1a and HNF4a -RRB- as a mechanism of arsenic_carcinogenesis .
8164696	0	hepatocyte_nuclear_factor_3_beta	52,84	Glucagon	0,8	hepatocyte nuclear factor 3 beta	Glucagon	25099(Tax:10116)	24952(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Glucagon gene expression is negatively regulated by hepatocyte_nuclear_factor_3_beta .
18593902	0	hepatocyte_nuclear_factor_3beta	53,84	15-Hydroxyprostaglandin_dehydrogenase	0,37	hepatocyte nuclear factor 3beta	15-Hydroxyprostaglandin dehydrogenase	3170	873	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	15-Hydroxyprostaglandin_dehydrogenase is a target of hepatocyte_nuclear_factor_3beta and a tumor suppressor in lung_cancer .
8943227	0	hepatocyte_nuclear_factor_3beta	4,35	insulin-like_growth_factor_I	78,106	hepatocyte nuclear factor 3beta	insulin-like growth factor I	3170	3479	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	The hepatocyte_nuclear_factor_3beta stimulates the transcription of the human insulin-like_growth_factor_I gene in a direct and indirect manner .
11230748	0	hepatocyte_nuclear_factor_4	30,57	Cytochrome_P450	0,15	hepatocyte nuclear factor 4	Cytochrome P450	3172	4051	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Cytochrome_P450 regulation by hepatocyte_nuclear_factor_4 in human hepatocytes : a study using adenovirus-mediated antisense targeting .
11811951	0	hepatocyte_nuclear_factor_4	74,101	aldehyde_dehydrogenase_2	37,61	hepatocyte nuclear factor 4	aldehyde dehydrogenase 2	3172	217	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Transcriptional control of the human aldehyde_dehydrogenase_2 promoter by hepatocyte_nuclear_factor_4 : inhibition by cyclic AMP and COUP transcription factors .
9765594	0	hepatocyte_nuclear_factor_4	73,100	aldehyde_dehydrogenase_2	36,60	hepatocyte nuclear factor 4	aldehyde dehydrogenase 2	25735(Tax:10116)	217	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Binding and activation of the human aldehyde_dehydrogenase_2 promoter by hepatocyte_nuclear_factor_4 .
17827402	0	hepatocyte_nuclear_factor_4_alpha	95,128	HNF4A	130,135	hepatocyte nuclear factor 4 alpha	HNF4A	3172	3172	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte_nuclear_factor_4_alpha -LRB- HNF4A -RRB- P2 region are associated with type 2 diabetes in Scandinavians .
16882880	0	hepatocyte_nuclear_factor_4alpha	60,92	CYP2C9	30,36	hepatocyte nuclear factor 4alpha	CYP2C9	3172	1559	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of CYP2C9 , CYP1A1 , and CYP1A2 by hepatocyte_nuclear_factor_4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid_receptor_coactivator_1 .
16455805	0	hepatocyte_nuclear_factor_4alpha	76,108	CYP3A4	24,30	hepatocyte nuclear factor 4alpha	CYP3A4	3172	1576	Gene	Gene	talk|nmod|START_ENTITY requires|dobj|talk requires|nsubj|induction induction|nmod|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
17344340	0	hepatocyte_nuclear_factor_4alpha	50,82	CYP3A4	29,35	hepatocyte nuclear factor 4alpha	CYP3A4	3172	1576	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Molecular mechanism of basal CYP3A4 regulation by hepatocyte_nuclear_factor_4alpha : evidence for direct regulation in the intestine .
12110948	0	hepatocyte_nuclear_factor_4alpha	13,45	HNF4alpha	47,56	hepatocyte nuclear factor 4alpha	HNF4alpha	3172	3172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells .
16895524	0	hepatocyte_nuclear_factor_4alpha	65,97	HNF4alpha	99,108	hepatocyte nuclear factor 4alpha	HNF4alpha	3172	3172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tumour suppressor p53 down-regulates the expression of the human hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- gene .
20622021	0	hepatocyte_nuclear_factor_4alpha	54,86	HNF4alpha	88,97	hepatocyte nuclear factor 4alpha	HNF4alpha	3172	3172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	CCAAT/enhancer-binding _ protein_alpha -LRB- C/EBPalpha -RRB- and hepatocyte_nuclear_factor_4alpha -LRB- HNF4alpha -RRB- synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome_P450_2B6 -LRB- CYP2B6 -RRB- gene : application to the development of a metabolically competent human hepatic cell model .
12774017	0	hepatocyte_nuclear_factor_4alpha	12,44	pregnane_X_receptor	63,82	hepatocyte nuclear factor 4alpha	pregnane X receptor	3172	8856	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the hepatocyte_nuclear_factor_4alpha in control of the pregnane_X_receptor during fetal liver development .
16455805	0	hepatocyte_nuclear_factor_4alpha	76,108	pregnane_X_receptor	40,59	hepatocyte nuclear factor 4alpha	pregnane X receptor	3172	8856	Gene	Gene	talk|nmod|START_ENTITY talk|compound|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
3294161	0	hepatocyte_stimulating_factor	75,104	interferon-beta_2	29,46	hepatocyte stimulating factor	interferon-beta 2	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Regional localization of the interferon-beta_2 / B-cell_stimulatory_factor_2 / hepatocyte_stimulating_factor gene to human chromosome 7p15-p21 .
22682760	0	hepatoma-derived_growth_factor	28,58	HDGF	60,64	hepatoma-derived growth factor	HDGF	3068	3068	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of nuclear hepatoma-derived_growth_factor -LRB- HDGF -RRB- localization in patients with breast_cancer .
23609195	0	hepatoma-derived_growth_factor	28,58	HDGF	60,64	hepatoma-derived growth factor	HDGF	3068	3068	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Downregulated expression of hepatoma-derived_growth_factor -LRB- HDGF -RRB- reduces gallbladder_cancer cell proliferation and invasion .
10854534	0	hepatoma_cell_lines_G-1_and_G-5	90,121	E-cadherin	66,76	hepatoma cell lines G-1 and G-5	E-cadherin	81845(Tax:10090)	12550(Tax:10090)	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation between metastatic potency and the down-regulation of E-cadherin in the mouse hepatoma_cell_lines_G-1_and_G-5 .
1846541	0	hepatopoietin_A	25,40	Hepatocyte_growth_factor	0,24	hepatopoietin A	Hepatocyte growth factor	24446(Tax:10116)	24446(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY END_ENTITY|parataxis|stimulates	Hepatocyte_growth_factor / hepatopoietin_A stimulates the growth of rat kidney proximal tubule epithelial cells -LRB- RPTE -RRB- , rat nonparenchymal liver cells , human melanoma cells , mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE .
12547227	0	hephaestin	26,36	ceruloplasmin	4,17	hephaestin	ceruloplasmin	15203(Tax:10090)	12870(Tax:10090)	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	The ceruloplasmin homolog hephaestin and the control of intestinal iron absorption .
20103725	0	her-2	96,101	Cyclooxygenase-2	0,16	her-2	Cyclooxygenase-2	13866(Tax:10090)	19225(Tax:10090)	Gene	Gene	model|amod|START_ENTITY inhibition|nmod|model inhibition|amod|END_ENTITY	Cyclooxygenase-2 inhibition for the prophylaxis and treatment of preinvasive breast_cancer in a her-2 / neu mouse model .
18182136	0	her-2	20,25	Neu	27,30	her-2	Neu	2064	2064	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical her-2 / Neu expression with gene amplification by fluorescence in situ hybridization for assessment in breast_carcinomas .
15087404	0	her-2	72,77	neu	78,81	her-2	neu	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|compound|END_ENTITY	Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2 / neu transgenic_mice .
10357943	0	her1	0,4	notch	58,63	her1	notch	30287(Tax:7955)	31293(Tax:7227)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	her1 , a zebrafish pair-rule like gene , acts downstream of notch signalling to control somite development .
21680730	0	her2/neu	67,75	p185	62,66	her2/neu	p185	2064	8661	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Structural insights into the down-regulation of overexpressed p185 -LRB- her2/neu -RRB- protein of transformed cells by the antibody chA21 .
10077665	0	heregulin	41,50	utrophin	13,21	heregulin	utrophin	211323(Tax:10090)	7402	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of utrophin gene expression by heregulin in skeletal muscle cells : role of the N-box motif and GA binding protein .
19895317	0	herpes_virus_entry_mediator	14,41	HVEM	43,47	herpes virus entry mediator	HVEM	8764	8764	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of herpes_virus_entry_mediator -LRB- HVEM -RRB- in the cornea and trigeminal_ganglia of normal and HSV-1 infected mice .
15536134	0	hes1	35,39	IkappaBalpha	15,27	hes1	IkappaBalpha	15205(Tax:10090)	18035(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression .
23776410	0	hes5	19,23	Fbw7	0,4	hes5	Fbw7	15208(Tax:10090)	50754(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Fbw7 repression by hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions .
15592864	0	heterochromatin_protein_1	17,42	HP1	44,47	heterochromatin protein 1	HP1	34119(Tax:7227)	34119(Tax:7227)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Mutations in the heterochromatin_protein_1 -LRB- HP1 -RRB- hinge domain affect HP1 protein interactions and chromosomal distribution .
8751383	0	heterochromatin_protein_1	38,63	M32	0,3	heterochromatin protein 1	M32	34119(Tax:7227)	12417(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	M32 , a murine homologue of Drosophila heterochromatin_protein_1 -LRB- HP1 -RRB- , localises to euchromatin within interphase nuclei and is largely excluded from constitutive heterochromatin .
11112778	0	heterochromatin_protein_1alpha	26,56	Ku70	6,10	heterochromatin protein 1alpha	Ku70	23468	2547	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human Ku70 interacts with heterochromatin_protein_1alpha .
19617346	0	heterochromatin_protein_1alpha	44,74	heterogeneous_nuclear_ribonucleoprotein_U	103,144	heterochromatin protein 1alpha	heterogeneous nuclear ribonucleoprotein U	23468	3192	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nsubj|interaction	Physical and functional interaction between heterochromatin_protein_1alpha and the RNA-binding protein heterogeneous_nuclear_ribonucleoprotein_U .
19656952	0	heterogeneous_nuclear_ribonucleoprotein_A1	101,143	DNA-dependent_protein_kinase	55,83	heterogeneous nuclear ribonucleoprotein A1	DNA-dependent protein kinase	3178	5591	Gene	Gene	phosphorylate|dobj|START_ENTITY END_ENTITY|acl|phosphorylate	The human telomerase RNA component , hTR , activates the DNA-dependent_protein_kinase to phosphorylate heterogeneous_nuclear_ribonucleoprotein_A1 .
1733858	0	heterogeneous_nuclear_ribonucleoprotein_A1	24,66	HNRPA1	73,79	heterogeneous nuclear ribonucleoprotein A1	HNRPA1	3178	3178	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human heterogeneous_nuclear_ribonucleoprotein_A1 gene -LRB- HNRPA1 -RRB- to chromosome 12q13 .1 by cDNA competitive in situ hybridization .
15687492	0	heterogeneous_nuclear_ribonucleoprotein_C	50,91	CK1alpha	15,23	heterogeneous nuclear ribonucleoprotein C	CK1alpha	3183	1452	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Protein kinase CK1alpha regulates mRNA binding by heterogeneous_nuclear_ribonucleoprotein_C in response to physiologic levels of hydrogen_peroxide .
24885469	0	heterogeneous_nuclear_ribonucleoprotein_K	42,83	Matrix_metalloproteinase_12	0,27	heterogeneous nuclear ribonucleoprotein K	Matrix metalloproteinase 12	3190	4321	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Matrix_metalloproteinase_12 is induced by heterogeneous_nuclear_ribonucleoprotein_K and promotes migration and invasion in nasopharyngeal_carcinoma .
24027268	0	heterogeneous_nuclear_ribonucleoprotein_K	43,84	c-Jun_N-terminal_kinase	0,23	heterogeneous nuclear ribonucleoprotein K	c-Jun N-terminal kinase	380255(Tax:8355)	379876(Tax:8355)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	c-Jun_N-terminal_kinase phosphorylation of heterogeneous_nuclear_ribonucleoprotein_K regulates vertebrate axon outgrowth via a posttranscriptional mechanism .
18202450	0	heterogeneous_nuclear_ribonucleoprotein_L	62,103	AUF1	42,46	heterogeneous nuclear ribonucleoprotein L	AUF1	3191	3184	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_D / AUF1 interacts with heterogeneous_nuclear_ribonucleoprotein_L .
9880507	0	heterogeneous_nuclear_ribonucleoprotein_L	84,125	vascular_endothelial_growth_factor	20,54	heterogeneous nuclear ribonucleoprotein L	vascular endothelial growth factor	3191	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|stability stability|compound|END_ENTITY	Regulation of human vascular_endothelial_growth_factor mRNA stability in hypoxia by heterogeneous_nuclear_ribonucleoprotein_L .
20554522	0	heterogeneous_nuclear_ribonucleoprotein_U	78,119	DNA_Topoisomerase_IIbeta	14,38	heterogeneous nuclear ribonucleoprotein U	DNA Topoisomerase IIbeta	3192	7155	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of DNA_Topoisomerase_IIbeta through RNA-dependent association with heterogeneous_nuclear_ribonucleoprotein_U -LRB- hnRNP_U -RRB- .
11530285	0	heterogeneous_nuclear_ribonucleoprotein_U	15,56	SAF-A	66,71	heterogeneous nuclear ribonucleoprotein U	SAF-A	51810(Tax:10090)	51810(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of the heterogeneous_nuclear_ribonucleoprotein_U -LRB- hnRNP_U / SAF-A -RRB- on glucocorticoid-dependent transcription in vivo .
19617346	0	heterogeneous_nuclear_ribonucleoprotein_U	103,144	heterochromatin_protein_1alpha	44,74	heterogeneous nuclear ribonucleoprotein U	heterochromatin protein 1alpha	3192	23468	Gene	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Physical and functional interaction between heterochromatin_protein_1alpha and the RNA-binding protein heterogeneous_nuclear_ribonucleoprotein_U .
15150282	0	hevin	42,47	SPARC	71,76	hevin	SPARC	13602(Tax:10090)	20692(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Expression and characterization of murine hevin -LRB- SC1 -RRB- , a member of the SPARC family of matricellular proteins .
19140804	0	hexokinase-II	34,47	GAPDH	0,5	hexokinase-II	GAPDH	3099	2597	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity .
12054864	0	hexokinase_2	41,53	Med8p	16,21	hexokinase 2	Med8p	852639(Tax:4932)	852492(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Mediator factor Med8p interacts with the hexokinase_2 : implication in the glucose signalling pathway of Saccharomyces_cerevisiae .
22354042	0	hexokinase_2	66,78	miR-143	16,23	hexokinase 2	miR-143	3099	406935	Gene	Gene	regulating|dobj|START_ENTITY glycolysis|advcl|regulating glycolysis|nsubj|controls controls|amod|END_ENTITY	A novel miR-155 / miR-143 cascade controls glycolysis by regulating hexokinase_2 in breast_cancer cells .
22469988	0	hexokinase_2	18,30	miR-143	0,7	hexokinase 2	miR-143	3099	406935	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-143 regulates hexokinase_2 expression in cancer cells .
22593586	0	hexokinase_2	65,77	miR-143	14,21	hexokinase 2	miR-143	3099	406935	Gene	Gene	gene|amod|START_ENTITY targeting|dobj|gene glycolysis|acl|targeting regulates|dobj|glycolysis regulates|nsubj|MicroRNA-143 MicroRNA-143|dep|END_ENTITY	MicroRNA-143 -LRB- miR-143 -RRB- regulates cancer glycolysis via targeting hexokinase_2 gene .
16954334	0	hexokinase_II	65,78	AMPKalpha2	8,18	hexokinase II	AMPKalpha2	15277(Tax:10090)	108079(Tax:10090)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of AMPKalpha2 in basal , training - , and AICAR-induced GLUT4 , hexokinase_II , and mitochondrial protein expression in mouse muscle .
26884725	0	hexokinase_II	32,45	HK2	47,50	hexokinase II	HK2	3099	3099	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of glycolytic enzyme hexokinase_II -LRB- HK2 -RRB- suppresses lung_tumor growth .
3905511	0	hexokinase_PII	35,49	HXK2	56,60	hexokinase PII	HXK2	852639(Tax:4932)	852639(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The primary structure of the yeast hexokinase_PII gene -LRB- HXK2 -RRB- which is responsible for glucose repression .
747188	0	hexosaminidase_A	28,44	HEX_A	46,51	hexosaminidase A	HEX A	3073	3073	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of unusual hexosaminidase_A -LRB- HEX_A -RRB- deficient human mutants .
11546764	0	hic-5	39,44	ARA55	45,50	hic-5	ARA55	7041	7041	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification and characterization of hic-5 / ARA55 as an hsp27 binding protein .
9664039	0	hic-5	31,36	LIM	19,22	hic-5	LIM	7041	10611	Gene	Gene	Recruitment|amod|START_ENTITY Recruitment|nmod|protein protein|compound|END_ENTITY	Recruitment of the LIM protein hic-5 to focal contacts of human platelets .
9931456	0	high-mobility-group_1	38,59	HMG1	61,65	high-mobility-group 1	HMG1	395724(Tax:9031)	395724(Tax:9031)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Selection of a cDNA clone for chicken high-mobility-group_1 -LRB- HMG1 -RRB- protein through its unusually conserved 3 ' - untranslated region , and improved expression of recombinant HMG1 in Escherichia_coli .
8760375	0	high-mobility-group_I	38,59	HMGI	61,65	high-mobility-group I	HMGI	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Calcium-dependent ADP-ribosylation of high-mobility-group_I -LRB- HMGI -RRB- proteins .
18402807	0	high-mobility_group_box-1	27,52	C-reactive_protein	0,18	high-mobility group box-1	C-reactive protein	15289(Tax:10090)	12944(Tax:10090)	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	C-reactive_protein induces high-mobility_group_box-1 protein release through activation of p38MAPK in macrophage RAW264 .7 cells .
17975839	0	high-mobility_group_box-1	42,67	HMGB1	69,74	high-mobility group box-1	HMGB1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Induction and subcellular localization of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in the postischemic rat brain .
22909167	0	high-mobility_group_box-1	12,37	HMGB1	39,44	high-mobility group box-1	HMGB1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in the pathogenesis of asthma .
23400574	0	high-mobility_group_box-1	19,44	HMGB1	46,51	high-mobility group box-1	HMGB1	3146	3146	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated levels of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in patients with severe or uncomplicated Plasmodium_falciparum malaria .
26765765	0	high-mobility_group_box-1	14,39	HMGB1	41,46	high-mobility group box-1	HMGB1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of high-mobility_group_box-1 -LRB- HMGB1 -RRB- in the basilar artery after experimental subarachnoid_hemorrhage .
22710699	0	high-mobility_group_box_1	12,37	HMGB-1	47,53	high-mobility group box 1	HMGB-1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Recombinant high-mobility_group_box_1 protein -LRB- HMGB-1 -RRB- promotes myeloid_differentiation_primary_response_protein_88 -LRB- Myd88 -RRB- upregulation in mouse primary cortical neurons .
26779828	0	high-mobility_group_box_1	29,54	HMGB-1	64,70	high-mobility group box 1	HMGB-1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The pro-inflammatory role of high-mobility_group_box_1 protein -LRB- HMGB-1 -RRB- in photoreceptors and retinal explants exposed to elevated pressure .
17334246	0	high-mobility_group_box_1	12,37	HMGB1	39,44	High-mobility group box 1	HMGB1	3146	3146	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Circulating high-mobility_group_box_1 -LRB- HMGB1 -RRB- concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis .
23658798	0	high-mobility_group_box_1	93,118	HMGB1	120,125	high-mobility group box 1	HMGB1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification and characterization of the direct interaction between methotrexate -LRB- MTX -RRB- and high-mobility_group_box_1 -LRB- HMGB1 -RRB- protein .
24306421	0	high-mobility_group_box_1	17,42	HMGB1	44,49	high-mobility group box 1	HMGB1	3146	3146	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Emerging role of high-mobility_group_box_1 -LRB- HMGB1 -RRB- in liver_diseases .
24383926	0	high-mobility_group_box_1	9,34	HMGB1	36,41	high-mobility group box 1	HMGB1	3146	3146	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Enhanced high-mobility_group_box_1 -LRB- HMGB1 -RRB- modulates regulatory T cells -LRB- Treg -RRB- / T helper 17 -LRB- Th17 -RRB- balance via toll-like receptor -LRB- TLR -RRB- -4 - interleukin -LRB- IL -RRB- -6 pathway in patients with chronic_hepatitis_B .
24924349	0	high-mobility_group_box_1	17,42	HMGB1	44,49	high-mobility group box 1	HMGB1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Early release of high-mobility_group_box_1 -LRB- HMGB1 -RRB- from neurons in experimental subarachnoid_hemorrhage in vivo and in vitro .
26880688	0	high-mobility_group_box_1	24,49	HMGB1	51,56	high-mobility group box 1	HMGB1	3146	3146	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	Plasma concentration of high-mobility_group_box_1 -LRB- HMGB1 -RRB- after 100 drop to vertical jumps and after a 1200-km bicycle race .
22217446	0	high-mobility_group_box_1	67,92	Toll-like_receptor_4	0,20	high-mobility group box 1	Toll-like receptor 4	15289(Tax:10090)	21898(Tax:10090)	Gene	Gene	senses|advcl|START_ENTITY senses|nsubj|END_ENTITY	Toll-like_receptor_4 on islet b cells senses expression changes in high-mobility_group_box_1 and contributes to the initiation of type 1 diabetes .
22189477	0	high-mobility_group_box_chromosomal_protein-1	36,81	HMGB-1	83,89	high-mobility group box chromosomal protein-1	HMGB-1	3146	3146	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression and localization of high-mobility_group_box_chromosomal_protein-1 -LRB- HMGB-1 -RRB- in human osteoarthritic cartilage .
23963851	0	high-temperature_requirement_A_serine_peptidase_1	24,73	HTRA1	75,80	high-temperature requirement A serine peptidase 1	HTRA1	5654	5654	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation of the high-temperature_requirement_A_serine_peptidase_1 -LRB- HTRA1 -RRB- gene in a Chinese family with cerebral_autosomal_recessive_arteriopathy_with_subcortical_infarcts_and_leukoencephalopathy -LRB- CARASIL -RRB- .
2072040	0	high_density_lipoprotein_3	44,70	apolipoprotein_E	14,30	high density lipoprotein 3	apolipoprotein E	114576(Tax:10090)	11816(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of apolipoprotein_E secretion by high_density_lipoprotein_3 in mouse macrophages .
15313913	0	high_mobility_group_A1	58,80	HMGA1	82,87	high mobility group A1	HMGA1	15361(Tax:10090)	15361(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Identification of the genes up - and down-regulated by the high_mobility_group_A1 -LRB- HMGA1 -RRB- proteins : tissue specificity of the HMGA1-dependent gene regulation .
16187170	0	high_mobility_group_A1	17,39	HMGA1	41,46	high mobility group A1	HMGA1	3159	3159	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Determination of high_mobility_group_A1 -LRB- HMGA1 -RRB- expression in hepatocellular_carcinoma : a potential prognostic marker .
18651940	0	high_mobility_group_A1	88,110	HMGA1	112,117	high mobility group A1	HMGA1	3159	3159	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic characterisation , chromosomal assignment and in vivo localisation of the canine high_mobility_group_A1 -LRB- HMGA1 -RRB- gene .
23036517	0	high_mobility_group_A1	32,54	HMGA1	56,61	high mobility group A1	HMGA1	3159	3159	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Functional relationship between high_mobility_group_A1 -LRB- HMGA1 -RRB- protein and insulin-like_growth_factor-binding_protein_3 -LRB- IGFBP-3 -RRB- in human chondrocytes .
26952843	0	high_mobility_group_A1	113,135	STAT3	144,149	high mobility group A1	STAT3	3159	6774	Gene	Gene	START_ENTITY|dep|pathway pathway|nummod|END_ENTITY	STAT3 inhibitor has potent antitumor activity in B-lineage acute_lymphoblastic_leukemia cells overexpressing the high_mobility_group_A1 -LRB- HMGA1 -RRB- - STAT3 pathway .
23625920	0	high_mobility_group_AT-hook_2	40,69	HMGA2	76,81	high mobility group AT-hook 2	TTF-1	8091	7270	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	MicroRNA-33a mediates the regulation of high_mobility_group_AT-hook_2 gene -LRB- HMGA2 -RRB- by thyroid_transcription_factor_1 -LRB- TTF-1 / NKX2-1 -RRB- .
19114373	0	high_mobility_group_Box-1	27,52	interleukin-6	69,82	high mobility group Box-1	interleukin-6	3146	3569	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	-LSB- Effect of progesterone on high_mobility_group_Box-1 protein-induced interleukin-6 release by human umbilic vein endothelial cells -RSB- .
9003504	0	high_mobility_group_I-C	4,27	HMGI-C	34,40	high mobility group I-C	HMGI-C	8091	8091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The high_mobility_group_I-C gene -LRB- HMGI-C -RRB- : polymorphism and genetic localization .
24531895	0	high_mobility_group_box	50,73	HMGB	75,79	high mobility group box	HMGB	6749	6749	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	A systematic nomenclature for the redox states of high_mobility_group_box -LRB- HMGB -RRB- proteins .
25810808	0	high_mobility_group_box-1	64,89	HMGB-1	91,97	high mobility group box-1	HMGB-1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CO2 pneumoperitoneum preserves b-arrestin 2 content and reduces high_mobility_group_box-1 -LRB- HMGB-1 -RRB- expression in an animal model of peritonitis .
19148477	0	high_mobility_group_box-1	47,72	HMGB1	74,79	high mobility group box-1	HMGB1	3146	3146	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Short hairpin RNA -LRB- shRNA -RRB- constructs targeting high_mobility_group_box-1 -LRB- HMGB1 -RRB- expression leads to inhibition of prostate_cancer cell survival and apoptosis .
25229664	0	high_mobility_group_box-1	8,33	growth_hormone	52,66	high mobility group box-1	growth hormone	25459(Tax:10116)	81668(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box-1 and protection of growth_hormone and somatostatin in severe_acute_pancreatitis .
25387675	0	high_mobility_group_box-1	8,33	growth_hormone	52,66	high mobility group box-1	growth hormone	25459(Tax:10116)	81668(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of high_mobility_group_box-1 and protection of growth_hormone and somatostatin in severe_acute_pancreatitis .
23508573	0	high_mobility_group_box_1	13,38	CD14	100,104	high mobility group box 1	CD14	3146	929	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nsubj|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
26261566	0	high_mobility_group_box_1	12,37	HMGB-1	39,45	high mobility group box 1	HMGB-1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of high_mobility_group_box_1 -LRB- HMGB-1 -RRB- in the diabetic_retinopathy_inflammation and apoptosis .
15379539	0	high_mobility_group_box_1	24,49	HMGB1	51,56	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The long acidic tail of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes .
19616266	0	high_mobility_group_box_1	30,55	HMGB1	57,62	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Factors associated with serum high_mobility_group_box_1 -LRB- HMGB1 -RRB- levels in a general population .
21872885	0	high_mobility_group_box_1	8,33	HMGB1	35,40	high mobility group box 1	HMGB1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of high_mobility_group_box_1 -LRB- HMGB1 -RRB- in wound healing .
22204001	0	high_mobility_group_box_1	26,51	HMGB1	53,58	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Poly -LRB- ADP-ribosyl -RRB- ation of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein enhances inhibition of efferocytosis .
22884669	0	high_mobility_group_box_1	25,50	HMGB1	52,57	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Elevated serum levels of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein in dengue-infected patients are associated with disease symptoms and secondary_infection .
23506269	0	high_mobility_group_box_1	20,45	HMGB1	47,52	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Systemic release of high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein is associated with severe and fatal Plasmodium_falciparum_malaria .
24578610	0	high_mobility_group_box_1	112,137	HMGB1	138,143	high mobility group box 1	HMGB1	25459(Tax:10116)	25459(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Ulinastatin preconditioning attenuates inflammatory reaction of hepatic_ischemia reperfusion injury in rats via high_mobility_group_box_1 -LRB- HMGB1 -RRB- inhibition .
24681824	0	high_mobility_group_box_1	12,37	HMGB1	39,44	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of high_mobility_group_box_1 -LRB- HMGB1 -RRB- in colorectal_cancer .
25669692	0	high_mobility_group_box_1	31,56	HMGB1	66,71	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Increased plasma levels of the high_mobility_group_box_1 protein -LRB- HMGB1 -RRB- are associated with a higher score of gastrointestinal_dysfunction in individuals with autism .
26367307	0	high_mobility_group_box_1	114,139	HMGB1	141,146	high mobility group box 1	HMGB1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Toll-like_receptor_4 signaling : A common pathway for interactions between prooxidants and extracellular disulfide high_mobility_group_box_1 -LRB- HMGB1 -RRB- protein-coupled activation .
26869083	0	high_mobility_group_box_1	63,88	HMGB1	90,95	high mobility group box 1	HMGB1	3146	3146	Gene	Gene	interactions|amod|START_ENTITY interactions|appos|END_ENTITY	Optimization of surface plasmon resonance experiments : Case of high_mobility_group_box_1 -LRB- HMGB1 -RRB- interactions .
12646658	0	high_mobility_group_box_1	18,43	IFN-gamma	0,9	high mobility group box 1	IFN-gamma	3146	3458	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	IFN-gamma induces high_mobility_group_box_1 protein release partly through a TNF-dependent mechanism .
23339448	0	high_mobility_group_box_1	14,39	thrombomodulin	153,167	high mobility group box 1	thrombomodulin	3146	7056	Gene	Gene	Role|nmod|START_ENTITY complicated|nsubj|Role complicated|nmod|systemic_inflammatory_response_syndrome systemic_inflammatory_response_syndrome|nmod|END_ENTITY	Role of serum high_mobility_group_box_1 in hematological_malignancies complicated with systemic_inflammatory_response_syndrome and effect of recombinant thrombomodulin .
23607598	0	high_mobility_group_box_1	15,40	thrombomodulin	83,97	high mobility group box 1	thrombomodulin	15289(Tax:10090)	21824(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of high_mobility_group_box_1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory_distress_syndrome .
24498917	0	high_mobility_group_box_1	96,121	thrombomodulin	8,22	high mobility group box 1	thrombomodulin	25459(Tax:10116)	83580(Tax:10116)	Gene	Gene	suppression|nmod|START_ENTITY sinusoidal_obstruction_syndrome|nmod|suppression sinusoidal_obstruction_syndrome|nsubj|attenuates attenuates|compound|END_ENTITY	Soluble thrombomodulin attenuates sinusoidal_obstruction_syndrome in rat through suppression of high_mobility_group_box_1 .
23508573	0	high_mobility_group_box_1	13,38	toll-like_receptor_4	55,75	high mobility group box 1	toll-like receptor 4	3146	7099	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
17196331	0	high_mobility_group_box_protein_1	42,75	HMGB1	77,82	high mobility group box protein 1	HMGB1	15289(Tax:10090)	15289(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Distribution and cellular localization of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in the spinal cord of a transgenic mouse model of ALS .
23143556	0	high_mobility_group_box_protein_1	25,58	HMGB1	60,65	high mobility group box protein 1	HMGB1	3146	3146	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated serum levels of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in patients with ankylosing_spondylitis and its association with disease activity and quality of life .
25779452	0	high_mobility_group_box_protein_1	8,41	HMGB1	43,48	high mobility group box protein 1	HMGB1	3146	3146	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in peripheral blood from patients with multiple_sclerosis .
25879961	0	high_mobility_group_box_protein_1	8,41	HMGB1	43,48	high mobility group box protein 1	HMGB1	3146	3146	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in peripheral blood from patients with multiple_sclerosis .
25879961	0	high_mobility_group_box_protein_1	8,41	HMGB1	43,48	high mobility group box protein 1	HMGB1	3146	3146	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of high_mobility_group_box_protein_1 -LRB- HMGB1 -RRB- in peripheral blood from patients with multiple_sclerosis .
12565837	0	high_mobility_group_protein-1	8,37	HMG1	39,43	high mobility group protein-1	HMG1	10354	10354	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of high_mobility_group_protein-1 -LRB- HMG1 -RRB- in amyloid-beta homeostasis .
26408615	0	high_mobility_group_protein_B1	30,60	TNF-a	1,6	high mobility group protein B1	TNF-a	3146	7124	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	-LSB- TNF-a induces the release of high_mobility_group_protein_B1 through p38 mitogen-activated protein kinase pathway in microglia -RSB- .
11390395	0	high_mobility_group_protein_HMGI-C	16,50	PIAS3	84,89	high mobility group protein HMGI-C	PIAS3	8091	10401	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Requirement for high_mobility_group_protein_HMGI-C interaction with STAT3 inhibitor PIAS3 in repression of alpha-subunit_of_epithelial_Na + _ channel -LRB- alpha-ENaC -RRB- transcription by Ras activation in salivary epithelial cells .
26806731	0	high_mobility_protein_box-1	50,77	THP-1	105,110	high mobility protein box-1	THP-1	3146	2736	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	-LSB- Role of nuclear factor of activated T cells-2 in high_mobility_protein_box-1 release in human monocytic THP-1 cells in vitro -RSB- .
16407841	0	high_molecular_weight-melanoma_associated_antigen	14,63	HMW-MAA	65,72	high molecular weight-melanoma associated antigen	HMW-MAA	1464	1464	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of high_molecular_weight-melanoma_associated_antigen -LRB- HMW-MAA -RRB- gene expression by promoter DNA methylation in human melanoma cells .
10845911	0	high_molecular_weight_kininogen	8,39	Mac-1	83,88	high molecular weight kininogen	Mac-1	3827	3684	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|CD11b/CD18 CD11b/CD18|appos|END_ENTITY	Cleaved high_molecular_weight_kininogen binds directly to the integrin CD11b/CD18 -LRB- Mac-1 -RRB- and blocks adhesion to fibrinogen and ICAM-1 .
6695362	0	high_molecular_weight_kininogen	14,45	fibrinogen	66,76	high molecular weight kininogen	fibrinogen	3827	2244	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of high_molecular_weight_kininogen on surface-adsorbed fibrinogen .
6339626	0	high_molecular_weight_kininogen	22,53	mast_cell_tryptase	63,81	high molecular weight kininogen	mast cell tryptase	3827	25823	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human high_molecular_weight_kininogen by human mast_cell_tryptase .
7855791	0	high_molecular_weight_kininogen	72,103	thrombin	44,52	high molecular weight kininogen	thrombin	3827	2147	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Surface independent factor XI activation by thrombin in the presence of high_molecular_weight_kininogen .
25086674	0	high_temperature_required_A2	46,74	HtrA2	76,81	high temperature required A2	HtrA2	27429	27429	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	The expression levels and prognostic value of high_temperature_required_A2 -LRB- HtrA2 -RRB- in NSCLC .
24135912	0	high_temperature_requirement_A1	13,44	TGF-beta1	68,77	high temperature requirement A1	TGF-beta1	56213(Tax:10090)	21803(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of high_temperature_requirement_A1 , a serine_protease , by TGF-beta1 in articular chondrocytes of mouse models of OA .
20651226	0	high_temperature_requirement_A2	32,63	Integrin_alpha_7	0,16	high temperature requirement A2	Integrin alpha 7	27429	3679	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Integrin_alpha_7 interacts with high_temperature_requirement_A2 -LRB- HtrA2 -RRB- to induce prostate_cancer cell death .
22556410	0	high_temperature_requirement_serine_protease_A1	27,74	HTRA1	76,81	high temperature requirement serine protease A1	HTRA1	5654	5654	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Detrimental role for human high_temperature_requirement_serine_protease_A1 -LRB- HTRA1 -RRB- in the pathogenesis of intervertebral disc -LRB- IVD -RRB- degeneration .
10693560	0	hip	44,47	Hip	0,3	hip	Hip	6159	6159	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Hip and knee replacement after longstanding hip arthrodesis .
8374487	0	hip	6,9	familial_Mediterranean_fever	25,53	hip	familial Mediterranean fever	6159	4210	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Total hip replacement in familial_Mediterranean_fever .
11372330	0	hip	41,44	hip	6,9	hip	hip	6159	6159	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Total hip replacement for the dislocated hip .
11372330	0	hip	6,9	hip	41,44	hip	hip	6159	6159	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Total hip replacement for the dislocated hip .
12226778	0	hip	57,60	hip	70,73	hip	hip	6159	6159	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Changes of biomechanical parameters in dysplasia of the hip by total hip replacement -RSB- .
12226778	0	hip	70,73	hip	57,60	hip	hip	6159	6159	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Changes of biomechanical parameters in dysplasia of the hip by total hip replacement -RSB- .
21550516	0	hip	38,41	hip	57,60	hip	hip	6159	6159	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Effect of surgical approach for total hip replacement on hip function using Harris Hip scores and Trendelenburg 's test .
21550516	0	hip	57,60	hip	38,41	hip	hip	6159	6159	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Effect of surgical approach for total hip replacement on hip function using Harris Hip scores and Trendelenburg 's test .
870982	0	hip	49,52	hip	6,9	hip	hip	6159	6159	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Total hip replacement in the previously infected hip .
870982	0	hip	6,9	hip	49,52	hip	hip	6159	6159	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Total hip replacement in the previously infected hip .
23637896	0	hippo	41,46	ste-20	11,17	hippo	ste-20	37247(Tax:7227)	32631(Tax:7227)	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	Drosophila ste-20 family protein kinase , hippo , modulates fat cell proliferation .
1280427	0	hippocalcin	21,32	recoverin	73,82	hippocalcin	recoverin	29177(Tax:10116)	140936(Tax:10116)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|family family|compound|END_ENTITY	Molecular cloning of hippocalcin , a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus .
10210891	0	hippocampal_cholinergic_neurostimulating_peptide	15,63	HCNP	65,69	hippocampal cholinergic neurostimulating peptide	HCNP	5037	5037	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	High levels of hippocampal_cholinergic_neurostimulating_peptide -LRB- HCNP -RRB- in the CSF of some patients with Alzheimer 's _ disease .
8720492	0	hippocampal_cholinergic_neurostimulating_peptide	16,64	HCNP	66,70	hippocampal cholinergic neurostimulating peptide	HCNP	29542(Tax:10116)	29542(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of hippocampal_cholinergic_neurostimulating_peptide -LRB- HCNP -RRB- immunoreactivity in the central nervous system of the rat .
171575	0	histaminase	9,20	diamine_oxidase	22,37	histaminase	diamine oxidase	26	26	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Elevated histaminase -LRB- diamine_oxidase -RRB- activity in small-cell carcinoma_of_the_lung .
96300	0	histaminase	36,47	diamine_oxidase	49,64	histaminase	diamine oxidase	26	26	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of histaminase -LRB- diamine_oxidase -RRB- in decidual cells of human placenta .
98973	0	histaminase	34,45	diamine_oxidase	17,32	histaminase	diamine oxidase	26	26	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Determination of diamine_oxidase -LRB- histaminase -RRB- activity .
1530666	0	histamine-N-methyltransferase	14,43	HNMT	45,49	histamine-N-methyltransferase	HNMT	81676(Tax:10116)	81676(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of histamine-N-methyltransferase -LRB- HNMT -RRB- by fragments of 9-amino-1 ,2,3,4 - tetrahydroacridine -LRB- tacrine -RRB- and by beta-carbolines .
16205835	0	histamine-N-methyltransferase	23,52	HNMT	54,58	histamine-N-methyltransferase	HNMT	3176	3176	Gene	Gene	association|nmod|START_ENTITY Lack|nmod|association Lack|appos|END_ENTITY	Lack of association of histamine-N-methyltransferase -LRB- HNMT -RRB- polymorphisms with asthma in the Indian population .
411497	0	histamine-N-methyltransferase	14,43	diamine_oxidase	61,76	histamine-N-methyltransferase	diamine oxidase	3176	26	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of histamine-N-methyltransferase and histaminase -LRB- diamine_oxidase -RRB- by a new histamine H2-receptor agonist , Dimaprit .
1702128	0	histamine-releasing_factor	22,48	HRF	50,53	histamine-releasing factor	HRF	7178	7178	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Altered production of histamine-releasing_factor -LRB- HRF -RRB- activity and responsiveness to HRF after immunotherapy in children with asthma .
9200485	0	histamine-releasing_factor	12,38	IL-4	62,66	histamine-releasing factor	IL-4	7178	3565	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Recombinant histamine-releasing_factor enhances IgE-dependent IL-4 and IL-13 secretion by human basophils .
19328828	0	histamine_H2_receptor	52,73	ANP	36,39	histamine H2 receptor	ANP	100338726(Tax:9986)	100009087(Tax:9986)	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Cardiac mast cells regulate myocyte ANP release via histamine_H2_receptor in beating rabbit atria .
11956964	0	histamine_H3_receptor	23,44	HRH3	51,55	histamine H3 receptor	HRH3	11255	11255	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure of the human histamine_H3_receptor gene -LRB- HRH3 -RRB- and identification of naturally occurring variations .
1968337	0	histamine_N-methyltransferase	14,43	HNMT	45,49	histamine N-methyltransferase	HNMT	3176	3176	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of histamine_N-methyltransferase -LRB- HNMT -RRB- in vitro by neuromuscular relaxants .
8339926	0	histamine_N-methyltransferase	53,82	HNMT	84,88	histamine N-methyltransferase	HNMT	3176	3176	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Genetic segregation analysis of red blood cell -LRB- RBC -RRB- histamine_N-methyltransferase -LRB- HNMT -RRB- activity .
23705015	0	histamine_N-methyltransferase-like	69,103	carnosine_N-methyltransferase	28,57	histamine N-methyltransferase-like	carnosine N-methyltransferase	771456(Tax:9031)	771456(Tax:9031)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Molecular identification of carnosine_N-methyltransferase as chicken histamine_N-methyltransferase-like protein -LRB- hnmt-like -RRB- .
12142541	0	histamine_receptor_H1	56,77	Bphs	18,22	histamine receptor H1	Bphs	15465(Tax:10090)	15465(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Bphs , an autoimmune_disease locus , as histamine_receptor_H1 .
8530107	0	histidase	63,72	HAL	79,82	histidase	HAL	3034	3034	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and structural characterization of the human histidase gene -LRB- HAL -RRB- .
1493926	0	histidine-rich_glycoprotein	68,95	Fc_receptor	25,36	histidine-rich glycoprotein	Fc receptor	94175(Tax:10090)	109615(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of macrophage Fc_receptor expression and phagocytosis by histidine-rich_glycoprotein .
19712047	0	histidine-rich_glycoprotein	14,41	HRG	43,46	histidine-rich glycoprotein	HRG	3273	3273	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of histidine-rich_glycoprotein -LRB- HRG -RRB- function via plasmin-mediated proteolytic cleavage .
6818678	0	histidine-rich_glycoprotein	28,55	HRG	57,60	histidine-rich glycoprotein	HRG	3273	3273	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Individual levels of plasma histidine-rich_glycoprotein -LRB- HRG -RRB- during the normal menstrual cycle and in women on oral contraceptives low in oestrogen .
7667832	0	histidine-rich_glycoprotein	24,51	HRG	53,56	histidine-rich glycoprotein	HRG	3273	3273	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Estrogens reduce plasma histidine-rich_glycoprotein -LRB- HRG -RRB- levels in a dose-dependent way .
3958188	0	histidine-rich_glycoprotein	15,42	fibrinogen	48,58	histidine-rich glycoprotein	fibrinogen	3273	2244	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of histidine-rich_glycoprotein with fibrinogen and fibrin .
20514075	0	histidine-triad_nucleotide-binding_protein-1	19,63	HINT1	65,70	histidine-triad nucleotide-binding protein-1	HINT1	3094	3094	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the histidine-triad_nucleotide-binding_protein-1 -LRB- HINT1 -RRB- gene variants with nicotine_dependence .
16849647	0	histidine_decarboxylase	58,81	BCR/ABL	28,35	histidine decarboxylase	BCR/ABL	15186(Tax:10090)	110279;11350	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The CML-related oncoprotein BCR/ABL induces expression of histidine_decarboxylase -LRB- HDC -RRB- and the synthesis of histamine in leukemic cells .
8074225	0	histidine_decarboxylase	18,41	Gastrin	0,7	histidine decarboxylase	Gastrin	24443(Tax:10116)	25320(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Gastrin regulates histidine_decarboxylase activity and mRNA abundance in rat oxyntic mucosa .
9142914	0	histidine_decarboxylase	28,51	Gastrin	0,7	histidine decarboxylase	Gastrin	3067	2520	Gene	Gene	promoter|compound|START_ENTITY regulates|dobj|promoter regulates|nsubj|END_ENTITY	Gastrin regulates the human histidine_decarboxylase promoter through an AP-1-dependent mechanism .
9341140	0	histidine_decarboxylase	63,86	Gastrin	0,7	histidine decarboxylase	Gastrin	3067	2520	Gene	Gene	promoter|compound|START_ENTITY regulate|dobj|promoter END_ENTITY|dep|regulate	Gastrin and phorbol_12-myristate_13-acetate regulate the human histidine_decarboxylase promoter through Raf-dependent activation of extracellular signal-regulated kinase-related signaling pathways in gastric_cancer cells .
10888469	0	histidine_decarboxylase	4,27	HDC	29,32	histidine decarboxylase	HDC	3067	3067	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The histidine_decarboxylase -LRB- HDC -RRB- gene of Tetrahymena_pyriformis is similar to the mammalian one .
6497830	0	histidine_decarboxylase	43,66	Hdc-s	19,24	histidine decarboxylase	Hdc-s	15186(Tax:10090)	15186(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	A structural gene -LRB- Hdc-s -RRB- for mouse kidney histidine_decarboxylase .
11478766	0	histidine_decarboxylase	23,46	Thrombopoietin	0,14	histidine decarboxylase	Thrombopoietin	3067	7066	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombopoietin induces histidine_decarboxylase gene expression in c-mpl transfected UT7 cells .
16357063	0	histidine_decarboxylase	27,50	Yin_yang_1	0,10	histidine decarboxylase	Yin yang 1	3067	7528	Gene	Gene	START_ENTITY|nsubj|represses represses|amod|END_ENTITY	Yin_yang_1 -LRB- YY1 -RRB- represses histidine_decarboxylase gene expression with SREBP-1a in part through an upstream Sp1 site .
11478766	0	histidine_decarboxylase	23,46	c-mpl	66,71	histidine decarboxylase	c-mpl	3067	4352	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Thrombopoietin induces histidine_decarboxylase gene expression in c-mpl transfected UT7 cells .
10409643	0	histidine_decarboxylase	20,43	gastrin	70,77	histidine decarboxylase	gastrin	3067	2520	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Activation of human histidine_decarboxylase gene promoter activity by gastrin is mediated by two distinct nuclear factors .
12372397	0	histidine_decarboxylase	95,118	gastrin	47,54	histidine decarboxylase	gastrin	3067	2520	Gene	Gene	promoter|amod|START_ENTITY Identification|nmod|promoter Identification|nmod|element element|compound|END_ENTITY	Identification and characterization of a third gastrin response element -LRB- GAS-RE3 -RRB- in the human histidine_decarboxylase gene promoter .
3460171	1	histidine_decarboxylase	116,139	gastrin	85,92	histidine decarboxylase	gastrin	24443(Tax:10116)	25320(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects on plasma gastrin and gastric histamine , histidine_decarboxylase activity and ECL cell density in normal and antrectomized rats .
4449071	0	histidine_decarboxylase	64,87	gastrin	26,33	histidine decarboxylase	gastrin	24443(Tax:10116)	25320(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Correlation Correlation|nmod|concentration concentration|compound|END_ENTITY	Correlation between serum gastrin concentration and rat stomach histidine_decarboxylase activity .
7250317	0	histidine_decarboxylase	46,69	gastrin	8,15	histidine decarboxylase	gastrin	24443(Tax:10116)	25320(Tax:10116)	Gene	Gene	rat|dobj|START_ENTITY rat|nsubj|END_ENTITY	Luminal gastrin does not activate rat stomach histidine_decarboxylase .
8662934	0	histidine_decarboxylase	10,33	gastrin	59,66	histidine decarboxylase	gastrin	3067	2520	Gene	Gene	promoter|compound|START_ENTITY regulated|nsubj|promoter regulated|nmod|END_ENTITY	The human histidine_decarboxylase promoter is regulated by gastrin and phorbol_12-myristate_13-acetate through a downstream cis-acting element .
8928792	0	histidine_decarboxylase	4,27	gastrin	53,60	histidine decarboxylase	gastrin	24443(Tax:10116)	25320(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY regulated|nsubjpass|promoter regulated|nmod|END_ENTITY	Rat histidine_decarboxylase promoter is regulated by gastrin through a protein kinase C pathway .
9361993	0	histidine_decarboxylase	47,70	gastrin	89,96	histidine decarboxylase	gastrin	24443(Tax:10116)	25320(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY suppresses|dobj|activity suppresses|advcl|affecting affecting|dobj|levels levels|compound|END_ENTITY	Glucose suppresses the activity of rat oxyntic histidine_decarboxylase without affecting gastrin levels .
10814538	0	histidine_decarboxylase	4,27	m-calpain	47,56	histidine decarboxylase	m-calpain	24443(Tax:10116)	29154(Tax:10116)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Rat histidine_decarboxylase is a substrate for m-calpain in vitro .
3905514	0	histidine_permease	4,22	HIP1	29,33	histidine permease	HIP1	853104(Tax:4932)	853104(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The histidine_permease gene -LRB- HIP1 -RRB- of Saccharomyces_cerevisiae .
18799291	0	histidine_triad_nucleotide-binding_protein_1	7,51	HINT1	53,58	histidine triad nucleotide-binding protein 1	HINT1	3094	3094	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Is the histidine_triad_nucleotide-binding_protein_1 -LRB- HINT1 -RRB- gene a candidate for schizophrenia ?
22930593	0	histidyl-tRNA_synthetase	40,64	HARS	66,70	histidyl-tRNA synthetase	HARS	3035	3035	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A loss-of-function variant in the human histidyl-tRNA_synthetase -LRB- HARS -RRB- gene is neurotoxic in vivo .
7755634	0	histidyl-tRNA_synthetase	69,93	HRS	95,98	histidyl-tRNA synthetase	HRS	3035	3035	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA_synthetase -LRB- HRS -RRB- gene encodes an mRNA that predicts a polypeptide homologous to HRS .
15469825	0	histone_H1	27,37	SirT1	6,11	histone H1	SirT1	3005	23411	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human SirT1 interacts with histone_H1 and promotes formation of facultative heterochromatin .
16046194	0	histone_H2AX	54,66	DNA-PK	0,6	histone H2AX	DNA-PK	3014	5591	Gene	Gene	phosphorylation|nmod|START_ENTITY responsible|nmod|phosphorylation responsible|nsubj|END_ENTITY	DNA-PK is responsible for enhanced phosphorylation of histone_H2AX under hypertonic conditions .
12660252	0	histone_H2AX	19,31	Mre11	50,55	histone H2AX	Mre11	3014	4361	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of histone_H2AX and activation of Mre11 , Rad50 , and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes .
19017647	0	histone_H4	79,89	Hho1p	40,45	histone H4	Hho1p	855701(Tax:4932)	855976(Tax:4932)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Saccharomyces_cerevisiae linker histone Hho1p functionally interacts with core histone_H4 and negatively regulates the establishment of transcriptionally silent chromatin .
22713239	0	histone_acetyltransferase_PCAF	4,34	p21	45,48	histone acetyltransferase PCAF	p21	8850	644914	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	The histone_acetyltransferase_PCAF regulates p21 transcription through stress-induced acetylation of histone H3 .
16645042	0	histone_acetyltransferase_binding_to_ORC-1	33,75	HBO1	77,81	histone acetyltransferase binding to ORC-1	HBO1	11143	11143	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Ligand-controlled interaction of histone_acetyltransferase_binding_to_ORC-1 -LRB- HBO1 -RRB- with the N-terminal transactivating domain of progesterone receptor induces steroid receptor coactivator 1-dependent coactivation of transcription .
20514024	0	histone_deacetylase	21,40	EGR1	0,4	histone deacetylase	EGR1	9734	1958	Gene	Gene	inhibitors|amod|START_ENTITY reactivation|nmod|inhibitors reactivation|nummod|END_ENTITY	EGR1 reactivation by histone_deacetylase inhibitors promotes synovial_sarcoma cell death through the PTEN tumor suppressor .
12477051	0	histone_deacetylase	39,58	ErbB2	30,35	histone deacetylase	ErbB2	9734	2064	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Transcriptional repression of ErbB2 by histone_deacetylase inhibitors detected by a genomically integrated ErbB2 promoter-reporting cell screen .
19359173	0	histone_deacetylase	98,117	HDAC	119,123	histone deacetylase	HDAC	9734	9734	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Exploring bis - -LRB- indolyl -RRB- methane moiety as an alternative and innovative CAP group in the design of histone_deacetylase -LRB- HDAC -RRB- inhibitors .
22005560	0	histone_deacetylase	18,37	HDAC	39,43	histone deacetylase	HDAC	9734	9734	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	-LSB- The effects of a histone_deacetylase -LRB- HDAC -RRB- inhibitor on endotoxin-induced endothelial cell injury -RSB- .
26185616	0	histone_deacetylase	76,95	HDAC	97,101	histone deacetylase	HDAC	9734	9734	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Cellular prostatic acid phosphatase -LRB- cPAcP -RRB- serves as a useful biomarker of histone_deacetylase -LRB- HDAC -RRB- inhibitors in prostate_cancer cell growth suppression .
24561820	0	histone_deacetylase	139,158	HDAC8	160,165	histone deacetylase	HDAC8	55869	55869	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis , molecular docking and cytotoxicity evaluation of novel 2 - -LRB- 4-amino-benzosulfonyl -RRB- -5 H-benzo -LSB- b -RSB- carbazole-6 ,11 - dione derivatives as histone_deacetylase -LRB- HDAC8 -RRB- inhibitors .
10403782	0	histone_deacetylase	33,52	MBP-1	0,5	histone deacetylase	MBP-1	9734	4153	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	MBP-1 physically associates with histone_deacetylase for transcriptional repression .
26980768	0	histone_deacetylase	9,28	RAD51	69,74	histone deacetylase	RAD51	9734	5888	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Enhanced histone_deacetylase activity in malignant_melanoma provokes RAD51 and FANCD2 triggered drug resistance .
26482938	0	histone_deacetylase	40,59	Rh2	18,21	histone deacetylase	Rh2	9734	6005	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Ginsenoside_20 -LRB- s -RRB- - Rh2 as potent natural histone_deacetylase inhibitors suppressing the growth of human leukemia cells .
14715264	0	histone_deacetylase	66,85	TRAIL	33,38	histone deacetylase	TRAIL	9734	8743	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone_deacetylase : role of Bcl-xL down-regulation .
11877441	0	histone_deacetylase	50,69	cyclooxygenase-1	30,46	histone deacetylase	cyclooxygenase-1	9734	5742	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Transcriptional regulation of cyclooxygenase-1 by histone_deacetylase inhibitors in normal human astrocyte cells .
15169878	0	histone_deacetylase	63,82	growth-differentiation_factor_11	18,50	histone deacetylase	growth-differentiation factor 11	9734	10220	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Activation of the growth-differentiation_factor_11 gene by the histone_deacetylase -LRB- HDAC -RRB- inhibitor trichostatin_A and repression by HDAC3 .
12151407	0	histone_deacetylase	20,39	hTERT	108,113	histone deacetylase	hTERT	9734	7015	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Sp1 and Sp3 recruit histone_deacetylase to repress transcription of human telomerase reverse transcriptase -LRB- hTERT -RRB- promoter in normal human somatic cells .
15337766	0	histone_deacetylase-1	100,121	cartilage_oligomeric_matrix_protein	135,170	histone deacetylase-1	cartilage oligomeric matrix protein	433759(Tax:10090)	12845(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Leukemia/lymphoma-related _ factor , a POZ domain-containing transcriptional repressor , interacts with histone_deacetylase-1 and inhibits cartilage_oligomeric_matrix_protein gene expression and chondrogenesis .
18611949	0	histone_deacetylase1	15,35	HDAC1	37,42	histone deacetylase1	HDAC1	3065	3065	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|appos|END_ENTITY	Requirement of histone_deacetylase1 -LRB- HDAC1 -RRB- in signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- nucleocytoplasmic distribution .
16409301	0	histone_deacetylase_1	46,67	Bcr-abl	5,12	histone deacetylase 1	BCR-ABL	3065	25	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	P210 Bcr-abl tyrosine kinase interaction with histone_deacetylase_1 modifies histone H4 acetylation and chromatin structure of chronic_myeloid_leukaemia haematopoietic progenitors .
21521687	0	histone_deacetylase_1	95,116	Liver-enriched_inhibitory_protein	0,33	histone deacetylase 1	Liver-enriched inhibitory protein	3065	23049	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Liver-enriched_inhibitory_protein -LRB- LIP -RRB- actively inhibits preadipocyte differentiation through histone_deacetylase_1 -LRB- HDAC1 -RRB- .
16511565	0	histone_deacetylase_1	108,129	Metastasis-associated_protein_1	0,31	histone deacetylase 1	Metastasis-associated protein 1	3065	9112	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Metastasis-associated_protein_1 enhances stability of hypoxia-inducible_factor-1alpha protein by recruiting histone_deacetylase_1 .
16409301	0	histone_deacetylase_1	46,67	P210	0,4	histone deacetylase 1	P210	3065	2125	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	P210 Bcr-abl tyrosine kinase interaction with histone_deacetylase_1 modifies histone H4 acetylation and chromatin structure of chronic_myeloid_leukaemia haematopoietic progenitors .
19637353	0	histone_deacetylase_1	50,71	SLC5A8	13,19	histone deacetylase 1	SLC5A8	3065	160728	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Transport by SLC5A8 with subsequent inhibition of histone_deacetylase_1 -LRB- HDAC1 -RRB- and HDAC3 underlies the antitumor activity of 3-bromopyruvate .
11427533	0	histone_deacetylase_1	21,42	TGIF2	0,5	histone deacetylase 1	TGIF2	3065	60436	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TGIF2 interacts with histone_deacetylase_1 and represses transcription .
10969803	0	histone_deacetylase_1	42,63	Transforming_growth_factor-beta1	0,32	histone deacetylase 1	Transforming growth factor-beta1	433759(Tax:10090)	21803(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Transforming_growth_factor-beta1 recruits histone_deacetylase_1 to a p130 repressor complex in transgenic_mice in vivo .
15964798	0	histone_deacetylase_1	94,115	death_receptor_5	56,72	histone deacetylase 1	death receptor 5	3065	8795	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcription factor NF-kappaB differentially regulates death_receptor_5 expression involving histone_deacetylase_1 .
16982778	0	histone_deacetylase_1	25,46	maspin	68,74	histone deacetylase 1	maspin	3065	5268	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Endogenous inhibition of histone_deacetylase_1 by tumor-suppressive maspin .
10969803	0	histone_deacetylase_1	42,63	p130	69,73	histone deacetylase 1	p130	433759(Tax:10090)	70769(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nmod|complex complex|amod|END_ENTITY	Transforming_growth_factor-beta1 recruits histone_deacetylase_1 to a p130 repressor complex in transgenic_mice in vivo .
20028735	0	histone_deacetylase_1	66,87	p21	38,41	histone deacetylase 1	p21	433759(Tax:10090)	12575(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The cyclin-dependent kinase inhibitor p21 is a crucial target for histone_deacetylase_1 as a regulator of cellular proliferation .
12808109	0	histone_deacetylase_1	140,161	p52	113,116	histone deacetylase 1	p52	3065	4791	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	p53 represses cyclin_D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone_deacetylase_1 .
18776063	0	histone_deacetylase_19	66,88	WRKY38	12,18	histone deacetylase 19	WRKY38	829969(Tax:3702)	832320(Tax:3702)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Arabidopsis WRKY38 and WRKY62 transcription factors interact with histone_deacetylase_19 in basal defense .
19139378	0	histone_deacetylase_2	117,138	B-type_natriuretic_peptide	28,54	histone deacetylase 2	B-type natriuretic peptide	3066	4879	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Endothelin-stimulated human B-type_natriuretic_peptide gene expression is mediated by Yin_Yang_1 in association with histone_deacetylase_2 .
15632075	0	histone_deacetylase_2	107,128	DNA_methyltransferase_3b	0,24	histone deacetylase 2	DNA methyltransferase 3b	84577(Tax:10116)	444985(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	DNA_methyltransferase_3b regulates nerve_growth_factor-induced differentiation of PC12 cells by recruiting histone_deacetylase_2 .
17312152	0	histone_deacetylase_2	206,227	ERalpha	233,240	histone deacetylase 2	ERalpha	3066	2099	Gene	Gene	dissociating|dobj|START_ENTITY dissociating|nmod|END_ENTITY	17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen_receptor_alpha -LRB- ERalpha -RRB- and augmentation of transcriptional activity of Sp1 by dissociating histone_deacetylase_2 from ERalpha .
19276356	0	histone_deacetylase_2	65,86	FOXP3	0,5	histone deacetylase 2	FOXP3	3066	50943	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	FOXP3 up-regulates p21 expression by site-specific inhibition of histone_deacetylase_2 / histone_deacetylase_4 association to the locus .
12176973	0	histone_deacetylase_2	72,93	Sp3	30,33	histone deacetylase 2	Sp3	3066	6670	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone_deacetylase_2 .
19139378	0	histone_deacetylase_2	117,138	Yin_Yang_1	86,96	histone deacetylase 2	Yin Yang 1	3066	7528	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Endothelin-stimulated human B-type_natriuretic_peptide gene expression is mediated by Yin_Yang_1 in association with histone_deacetylase_2 .
24833798	0	histone_deacetylase_2	56,77	arginase_2	42,52	histone deacetylase 2	arginase 2	3066	384	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of endothelial arginase_2 by histone_deacetylase_2 .
18849323	0	histone_deacetylase_2	14,35	inducible_heat_shock_protein_70	39,70	histone deacetylase 2	inducible heat shock protein 70	15182(Tax:10090)	193740(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of histone_deacetylase_2 by inducible_heat_shock_protein_70 in cardiac_hypertrophy .
19276356	0	histone_deacetylase_2	65,86	p21	19,22	histone deacetylase 2	p21	3066	644914	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	FOXP3 up-regulates p21 expression by site-specific inhibition of histone_deacetylase_2 / histone_deacetylase_4 association to the locus .
22027828	0	histone_deacetylase_3	78,99	Galectin-9	0,10	histone deacetylase 3	Galectin-9	8841	3965	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Galectin-9 protein expression in endothelial cells is positively regulated by histone_deacetylase_3 .
22570481	0	histone_deacetylase_3	54,75	emerin	29,35	histone deacetylase 3	emerin	8841	2010	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The nuclear envelope protein emerin binds directly to histone_deacetylase_3 -LRB- HDAC3 -RRB- and activates HDAC3 activity .
16293940	0	histone_deacetylase_4	29,50	HDAC4	52,57	histone deacetylase 4	HDAC4	208727(Tax:10090)	208727(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Stage specific expression of histone_deacetylase_4 -LRB- HDAC4 -RRB- during oogenesis and early preimplantation development in mice .
21242980	0	histone_deacetylase_4	44,65	androgen_receptor	14,31	histone deacetylase 4	androgen receptor	9759	367	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of androgen_receptor activity by histone_deacetylase_4 through receptor SUMOylation .
16051668	0	histone_deacetylase_4	15,36	estrogen_receptor_alpha	65,88	histone deacetylase 4	estrogen receptor alpha	9759	2099	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|nmod|END_ENTITY	Recruitment of histone_deacetylase_4 to the N-terminal region of estrogen_receptor_alpha .
25424126	0	histone_deacetylase_4	108,129	runt-related_transcription_factor-2	144,179	histone deacetylase 4	runt-related transcription factor-2	9759	860	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Decreased histone_deacetylase_4 is associated with human osteoarthritis cartilage_degeneration by releasing histone_deacetylase_4 inhibition of runt-related_transcription_factor-2 and increasing osteoarthritis-related genes : a novel mechanism of human osteoarthritis cartilage_degeneration .
11018260	0	histone_deacetylase_5	55,76	HDAC5	83,88	histone deacetylase 5	HDAC5	10014	10014	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal organization and localization of the human histone_deacetylase_5 gene -LRB- HDAC5 -RRB- .
16584705	0	histone_deacetylase_5	41,62	Protein_kinase_D	0,16	histone deacetylase 5	Protein kinase D	10014	5587	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Protein_kinase_D directly phosphorylates histone_deacetylase_5 via a random sequential kinetic mechanism .
21454484	0	histone_deacetylase_5	70,91	beta-catenin	39,51	histone deacetylase 5	beta-catenin	15184(Tax:10090)	12387(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	AMP-activated protein kinase regulates beta-catenin transcription via histone_deacetylase_5 .
23926128	0	histone_deacetylase_5	77,98	myogenin	38,46	histone deacetylase 5	myogenin	15184(Tax:10090)	17928(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	AMP-activated protein kinase mediates myogenin expression and myogenesis via histone_deacetylase_5 .
22174839	0	histone_deacetylase_6	25,46	Dysferlin	0,9	histone deacetylase 6	Dysferlin	10013	8291	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dysferlin interacts with histone_deacetylase_6 and increases alpha-tubulin acetylation .
24089523	0	histone_deacetylase_6	59,80	Extracellular_signal-regulated_kinase	0,37	histone deacetylase 6	Extracellular signal-regulated kinase	15185(Tax:10090)	26413(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- phosphorylates histone_deacetylase_6 -LRB- HDAC6 -RRB- at serine 1035 to stimulate cell migration .
24747960	0	histone_deacetylase_6	19,40	IL10	122,126	histone deacetylase 6	IL10	10013	3586	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Divergent roles of histone_deacetylase_6 -LRB- HDAC6 -RRB- and histone_deacetylase_11 -LRB- HDAC11 -RRB- on the transcriptional regulation of IL10 in antigen presenting cells .
12391164	0	histone_deacetylase_6	36,57	Runx2	0,5	histone deacetylase 6	Runx2	10013	860	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Runx2 -LRB- Cbfa1 , AML-3 -RRB- interacts with histone_deacetylase_6 and represses the p21 -LRB- CIP1/WAF1 -RRB- promoter .
20308065	0	histone_deacetylase_6	52,73	TPPP/p25	0,8	histone deacetylase 6	TPPP/p25	10013	11076	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	TPPP/p25 promotes tubulin acetylation by inhibiting histone_deacetylase_6 .
22490492	0	histone_deacetylase_6	18,39	glucocorticoid_receptor	91,114	histone deacetylase 6	glucocorticoid receptor	10013	2908	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Nicotine inhibits histone_deacetylase_6 activity and chaperone-dependent activation of the glucocorticoid_receptor in A549 cells .
18506539	0	histone_deacetylase_7	5,26	HDAC7	28,33	histone deacetylase 7	HDAC7	51564	51564	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	High histone_deacetylase_7 -LRB- HDAC7 -RRB- expression is significantly associated with adenocarcinomas of the pancreas .
19029091	0	histone_deacetylase_7	66,87	Runx2	119,124	histone deacetylase 7	Runx2	51564	860	Gene	Gene	localization|amod|START_ENTITY localization|nmod|END_ENTITY	Bone_morphogenic_protein_2 activates protein_kinase_D to regulate histone_deacetylase_7 localization and repression of Runx2 .
22391568	0	histone_deacetylase_8	69,90	p53	47,50	histone deacetylase 8	p53	55869	7157	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Histone deacetylase inhibitors suppress mutant p53 transcription via histone_deacetylase_8 .
12054582	0	histone_deacetylase_9	55,76	HDAC9	83,88	histone deacetylase 9	HDAC9	9734	9734	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal organization and localization of the human histone_deacetylase_9 gene -LRB- HDAC9 -RRB- .
22791246	0	histone_deacetylases	38,58	Nox4	30,34	histone deacetylases	Nox4	9734	50507	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Nox4 by histone_deacetylases in human endothelial cells .
26819089	0	histone_demethylase_UTX	54,77	E-cadherin	25,35	histone demethylase UTX	E-cadherin	7403	999	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Epigenetic regulation of E-cadherin expression by the histone_demethylase_UTX in colon_cancer cells .
24813891	0	histone_methyltransferase	4,29	MLL1	42,46	histone methyltransferase	MLL1	3176	4297	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The histone_methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis .
17826007	0	histone_nuclear_factor_P	34,58	HiNF-P	60,66	histone nuclear factor P	HiNF-P	25988	25988	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the histone_nuclear_factor_P -LRB- HiNF-P -RRB- gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition .
17826007	0	histone_nuclear_factor_P	34,58	HiNF-P	76,82	histone nuclear factor P	HiNF-P	25988	25988	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the histone_nuclear_factor_P -LRB- HiNF-P -RRB- gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition .
18508862	0	hlh-17	42,48	mls-2	0,5	hlh-17	mls-2	185460(Tax:6239)	180751(Tax:6239)	Gene	Gene	development|amod|START_ENTITY development|compound|END_ENTITY	mls-2 and vab-3 Control glia development , hlh-17 / Olig expression and glia-dependent neurite extension in C. _ elegans .
18706403	0	hlh-6	54,59	LAG-1	29,34	hlh-6	LAG-1	188539(Tax:6239)	177373(Tax:6239)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. _ elegans .
23826137	0	hltf	44,48	helicase-like_transcription_factor	8,42	hltf	helicase-like transcription factor	20585(Tax:10090)	20585(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of helicase-like_transcription_factor -LRB- hltf -RRB- in the G2/m transition and apoptosis in brain .
26337933	0	hmox1	42,47	heme_oxygenase-1	24,40	hmox1	heme oxygenase-1	3162	3162	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	Leukocyte expression of heme_oxygenase-1 -LSB- hmox1 -RSB- varies inversely with severity of tricuspid_regurgitation in acute_pulmonary_embolism .
18669443	0	hnRNP	11,16	DAZAP1	0,6	hnRNP	DAZAP1	56258(Tax:10090)	70248(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	DAZAP1 , an hnRNP protein , is required for normal growth and spermatogenesis in mice .
19931428	0	hnRNP	34,39	HuR	25,28	hnRNP	HuR	3183	1994	Gene	Gene	proteins|compound|START_ENTITY association|nmod|proteins association|nmod|END_ENTITY	Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes .
19931428	0	hnRNP	71,76	HuR	25,28	hnRNP	HuR	3183	1994	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes .
518927	0	hnRNP	31,36	Protein_kinase	0,14	hnRNP	Protein kinase	9987	1022	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|END_ENTITY	Protein_kinase associated with hnRNP from Hela cell nuclei .
15676023	0	hnRNP	10,15	Smooth	0,6	hnRNP	Smooth	33968(Tax:7227)	37254(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Smooth , a hnRNP encoding gene , controls axonal navigation in Drosophila .
19931428	0	hnRNP	34,39	hnRNP	71,76	hnRNP	hnRNP	3183	3183	Gene	Gene	proteins|compound|START_ENTITY association|nmod|proteins association|nmod|END_ENTITY	Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes .
19931428	0	hnRNP	71,76	hnRNP	34,39	hnRNP	hnRNP	3183	3183	Gene	Gene	association|nmod|START_ENTITY association|nmod|proteins proteins|compound|END_ENTITY	Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes .
27012187	0	hnRNP-K	42,49	CASC11	20,26	hnRNP-K	CASC11	3190	100270680	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/b-catenin pathway to promote growth and metastasis in colorectal_cancer .
11231586	0	hnRNP-K	55,62	ERK	0,3	hnRNP-K	ERK	3190	5594	Gene	Gene	accumulation|nmod|START_ENTITY drives|dobj|accumulation drives|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation .
19880579	0	hnRNP-K	0,7	ERK	45,48	hnRNP-K	ERK	3190	5594	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation .
24642125	0	hnRNP-K	24,31	angiopoietin-1	100,114	hnRNP-K	angiopoietin-1	3190	284	Gene	Gene	mediates|nsubj|START_ENTITY mediates|advcl|END_ENTITY	The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling_protein-2 by angiopoietin-1 .
24642125	0	hnRNP-K	24,31	uncoupling_protein-2	76,96	hnRNP-K	uncoupling protein-2	3190	7351	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling_protein-2 by angiopoietin-1 .
12576095	0	hnRNP-L	14,21	PLG	0,3	hnRNP-L	PLG	80846(Tax:10116)	85253(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex : identification by ddPCR .
11773003	0	hnRNP-R	88,95	Smn	128,131	hnRNP-R	Smn	10236	6606	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|role role|nmod|END_ENTITY	Specific interaction of Smn , the spinal_muscular_atrophy determining gene product , with hnRNP-R and gry-rbp/hnRNP-Q : a role for Smn in RNA processing in motor axons ?
11773003	0	hnRNP-R	88,95	Smn	24,27	hnRNP-R	Smn	10236	6606	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of Smn , the spinal_muscular_atrophy determining gene product , with hnRNP-R and gry-rbp/hnRNP-Q : a role for Smn in RNA processing in motor axons ?
18197392	0	hnRNP-R	0,7	c-fos	34,39	hnRNP-R	c-fos	319110(Tax:10116)	314322(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	hnRNP-R regulates the PMA-induced c-fos expression in retinal cells .
16924231	0	hnRNP-U	0,7	WT1	32,35	hnRNP-U	WT1	3192	7490	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation .
24550987	0	hnRNPA1	62,69	GSK3beta	25,33	hnRNPA1	GSK3beta	3178	2932	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	AR-A_014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors .
21099359	0	hnRNPA2B1	34,43	BRCA1	0,5	hnRNPA2B1	BRCA1	3181	672	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	BRCA1 modulates the expression of hnRNPA2B1 and KHSRP .
23549171	0	hnRNPK	12,18	ATM	0,3	hnRNPK	ATM	3190	472	Gene	Gene	START_ENTITY|nsubj|targets targets|compound|END_ENTITY	ATM targets hnRNPK to control p53 .
21821029	0	hnRNPK	24,30	Aurora-A	0,8	hnRNPK	Aurora-A	3190	6790	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53 .
17010310	0	hnRNPQ	21,27	NSAP1	29,34	hnRNPQ	NSAP1	10492	10492	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The acidic domain of hnRNPQ -LRB- NSAP1 -RRB- has structural similarity to Barstar and binds to Apobec1 .
3062579	0	hnRNP_A1	14,22	epidermal_growth_factor	50,73	hnRNP A1	epidermal growth factor	29578(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression Modulation|nmod|END_ENTITY	Modulation of hnRNP_A1 protein gene expression by epidermal_growth_factor in Rat-1 cells .
12209876	0	hnRNP_A1	55,63	p16INK4a	32,40	hnRNP A1	p16INK4a	3178	1029	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Modulation of the expression of p16INK4a and p14ARF by hnRNP_A1 and A2 RNA binding proteins : implications for cellular senescence .
24572810	0	hnRNP_A2	16,24	A-Raf	75,80	hnRNP A2	A-Raf	3181	369	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Splicing factor hnRNP_A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular_carcinoma development .
19024322	0	hnRNP_B1	12,20	DNA-PK	24,30	hnRNP B1	DNA-PK	3181	5591	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	-LSB- Effects of hnRNP_B1 on DNA-PK activity , cell cycle and apoptosis in human lung_adenocarcinoma cell line A549 -RSB- .
23831410	0	hnRNP_C	20,27	CD80	77,81	hnRNP C	CD80	15381(Tax:10090)	12519(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The splicing factor hnRNP_C regulates expression of co-stimulatory molecules CD80 and CD40 in dendritic cells .
23478261	0	hnRNP_E1	72,80	endothelial_nitric_oxide_synthase	30,63	hnRNP E1	endothelial nitric oxide synthase	5093	4846	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Active stabilization of human endothelial_nitric_oxide_synthase mRNA by hnRNP_E1 protects against antisense RNA and microRNAs .
24978456	0	hnRNP_F	0,7	tristetraprolin	23,38	hnRNP F	tristetraprolin	3185	7538	Gene	Gene	complexes|compound|START_ENTITY complexes|nmod|END_ENTITY	hnRNP_F complexes with tristetraprolin and stimulates ARE-mRNA decay .
21327109	0	hnRNP_G	21,28	RBMX	29,33	hnRNP G	RBMX	27316	27316	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Novel domains in the hnRNP_G / RBMX protein with distinct roles in RNA binding and targeting nascent transcripts .
18573884	0	hnRNP_H	0,7	Fox2	33,37	hnRNP H	Fox2	3187	23543	Gene	Gene	complex|compound|START_ENTITY complex|nmod|END_ENTITY	hnRNP_H and hnRNP_F complex with Fox2 to silence fibroblast_growth_factor_receptor_2 exon IIIc .
26656491	0	hnRNP_I	43,50	Linc-RoR	0,8	hnRNP I	Linc-RoR	5725	100885779	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Linc-RoR promotes c-Myc expression through hnRNP_I and AUF1 .
23519117	0	hnRNP_K	18,25	Caspase-3	0,9	hnRNP K	Caspase-3	3190	836	Gene	Gene	START_ENTITY|nsubj|cleaves cleaves|amod|END_ENTITY	Caspase-3 cleaves hnRNP_K in erythroid differentiation .
18295448	0	hnRNP_K	109,116	PKCdelta	0,8	hnRNP K	PKCdelta	15387(Tax:10090)	18753(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	PKCdelta regulates the stimulation of vascular endothelial factor mRNA translation by angiotensin II through hnRNP_K .
20548952	0	hnRNP_K	16,23	PKCdelta	97,105	hnRNP K	PKCdelta	15387(Tax:10090)	18753(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY induces|nsubj|Inactivation induces|dobj|apoptosis apoptosis|nmod|translocation translocation|nmod|END_ENTITY	Inactivation of hnRNP_K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar_ataxia_10 .
19170760	0	hnRNP_K	0,7	RNA_binding_motif_protein_42	23,51	hnRNP K	RNA binding motif protein 42	3190	79171	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	hnRNP_K interacts with RNA_binding_motif_protein_42 and functions in the maintenance of cellular ATP level during stress conditions .
12595559	0	hnRNP_K	62,69	SRC	22,25	hnRNP K	SRC	3190	6714	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Identification of the SRC pyrimidine-binding protein -LRB- SPy -RRB- as hnRNP_K : implications in the regulation of SRC1A transcription .
24751651	0	hnRNP_K	36,43	TAK1	23,27	hnRNP K	TAK1	3190	6885	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Translation control of TAK1 mRNA by hnRNP_K modulates LPS-induced macrophage activation .
17178840	0	hnRNP_K	85,92	c-Src	58,63	hnRNP K	c-Src	3190	6714	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Deciphering the cross talk between hnRNP_K and c-Src : the c-Src activation domain in hnRNP_K is distinct from a second interaction site .
16360036	0	hnRNP_K	0,7	p53	59,62	hnRNP K	p53	3190	7157	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	hnRNP_K : an HDM2 target and transcriptional coactivator of p53 in response to DNA damage .
15781475	0	hnRNP_M	10,17	Hrp59	0,5	hnRNP M	Hrp59	41138(Tax:7227)	41138(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Hrp59 , an hnRNP_M protein in Chironomus and Drosophila , binds to exonic splicing enhancers and is required for expression of a subset of mRNAs .
19874820	0	hnRNP_M	0,7	PSF	23,26	hnRNP M	PSF	4670	6421	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	hnRNP_M interacts with PSF and p54 -LRB- nrb -RRB- and co-localizes within defined nuclear structures .
15816515	0	hnRNP_M4	38,46	CEA	23,26	hnRNP M4	CEA	4670	1084	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Surface expression and CEA binding of hnRNP_M4 protein in HT29 colon_cancer cells .
11813259	0	hnRNP_U	44,51	Necdin	0,6	hnRNP U	Necdin	51810(Tax:10090)	17984(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Necdin interacts with the ribonucleoprotein hnRNP_U in the nuclear matrix .
9353307	0	hnRNP_U	86,93	glucocorticoid_receptor	4,27	hnRNP U	glucocorticoid receptor	3192	2908	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The glucocorticoid_receptor is associated with the RNA-binding nuclear matrix protein hnRNP_U .
10674400	0	hnf6	152,156	growth_hormone	165,179	hnf6	growth hormone	25231(Tax:10116)	81668(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Involvement of STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- and HNF-4 -LRB- hepatocyte_nuclear_factor_4 -RRB- in the transcriptional control of the hnf6 gene by growth_hormone .
9630604	0	holocarboxylase_synthetase	18,44	HCS	46,49	holocarboxylase synthetase	HCS	3141	3141	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Identification of holocarboxylase_synthetase -LRB- HCS -RRB- proteins in human placenta .
23403989	0	homeobox_A9	77,88	E-selectin	51,61	homeobox A9	E-selectin	3205	6401	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	shRNAs targeting high-mobility_group_box-1 inhibit E-selectin expression via homeobox_A9 in human umbilical vein endothelial cells .
26255015	0	homeobox_A9	92,103	E-selectin	66,76	homeobox A9	E-selectin	3205	6401	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- shRNAs targeting high_mobility_group_box-1 lead to inhibition of E-selectin expression via homeobox_A9 in human umbilical vein endothelial cells -RSB- .
24582746	0	homeobox_B9	14,25	transforming_growth_factor-b1	60,89	homeobox B9	transforming growth factor-b1	3219	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Overexpressed homeobox_B9 regulates oncogenic activities by transforming_growth_factor-b1 in gliomas .
24386080	0	homeobox_D10	36,48	IGFBP3	0,6	homeobox D10	IGFBP3	3236	3486	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	IGFBP3 , a transcriptional target of homeobox_D10 , is correlated with the prognosis of gastric_cancer .
11740489	0	homeodomain-interacting_protein_kinase-2	51,91	p53	14,17	homeodomain-interacting protein kinase-2	p53	28996	7157	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of p53 activity by its interaction with homeodomain-interacting_protein_kinase-2 .
18483253	0	homeodomain-interacting_protein_kinase-2	50,90	p53	36,39	homeodomain-interacting protein kinase-2	p53	28996	7157	Gene	Gene	knockdown|amod|START_ENTITY END_ENTITY|nmod|knockdown	Reversible dysfunction of wild-type p53 following homeodomain-interacting_protein_kinase-2 knockdown .
18644116	0	homeodomain-interacting_protein_kinase-2	63,103	vascular_endothelial_growth_factor	14,48	homeodomain-interacting protein kinase-2	vascular endothelial growth factor	28996	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by homeodomain-interacting_protein_kinase-2 .
26247811	0	homeodomain-interacting_protein_kinase_2	46,86	CREB-binding_protein	22,42	homeodomain-interacting protein kinase 2	CREB-binding protein	28996	1387	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Complex regulation of CREB-binding_protein by homeodomain-interacting_protein_kinase_2 .
12907596	0	homeodomain-interacting_protein_kinase_2	20,60	PML	0,3	homeodomain-interacting protein kinase 2	PML	28996	5371	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	PML is required for homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- - mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains .
16407227	0	homeodomain-interacting_protein_kinase_2	47,87	Pax6	39,43	homeodomain-interacting protein kinase 2	Pax6	28996	5080	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and transactivation of Pax6 by homeodomain-interacting_protein_kinase_2 .
12907596	0	homeodomain-interacting_protein_kinase_2	20,60	p53	78,81	homeodomain-interacting protein kinase 2	p53	28996	7157	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|compound|END_ENTITY	PML is required for homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- - mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains .
8258719	0	homodimer	87,96	CD64	46,50	homodimer	CD64	6647	2209	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association of all three types of Fc gamma R -LRB- CD64 , CD32 , and CD16 -RRB- with a gamma-chain homodimer in cultured human monocytes .
16081415	0	homodimer	45,54	SIRPbeta1	0,9	homodimer	SIRPbeta1	6647	10326	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration .
3082984	0	homodimer	29,38	interleukin_2	49,62	homodimer	interleukin 2	6647	3558	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	A 44 kilodalton cell surface homodimer regulates interleukin_2 production by activated human T lymphocytes .
7794748	0	homologous_restriction_factor_20KD	28,62	HRF20	64,69	homologous restriction factor 20KD	HRF20	966	966	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Flow cytometric analysis of homologous_restriction_factor_20KD -LRB- HRF20 -RRB- expression on progeny cells during differentiation from haemopoietic progenitors in paroxysmal_nocturnal_haemoglobinuria .
16467492	0	hormone-receptor	49,65	insulin-like_peptide_3	18,40	hormone-receptor	insulin-like peptide 3	3164	3640	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Expression of the insulin-like_peptide_3 -LRB- INSL3 -RRB- hormone-receptor -LRB- LGR8 -RRB- system in the testis .
10832769	0	hormone-sensitive_lipase	66,90	HSL	92,95	hormone-sensitive lipase	HSL	25330(Tax:10116)	25330(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Free fatty_acids are involved in the inverse relationship between hormone-sensitive_lipase -LRB- HSL -RRB- activity and expression in adipose tissue after high-fat feeding or beta3-adrenergic stimulation .
20691154	0	hormone-sensitive_lipase	21,45	HSL	47,50	hormone-sensitive lipase	HSL	25330(Tax:10116)	25330(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Testosterone affects hormone-sensitive_lipase -LRB- HSL -RRB- activity and lipid metabolism in the left ventricle .
24443229	0	hormone-sensitive_lipase	23,47	HSL	54,57	hormone-sensitive lipase	HSL	100169699(Tax:9940)	100169699(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the ovine hormone-sensitive_lipase gene -LRB- HSL -RRB- and its association with growth and carcass traits in New Zealand Suffolk sheep .
16269451	0	hormone-sensitive_lipase	80,104	Peroxisome_proliferator-activated_receptor-gamma	0,48	hormone-sensitive lipase	Peroxisome proliferator-activated receptor-gamma	3991	5468	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma transcriptionally up-regulates hormone-sensitive_lipase via the involvement of specificity_protein-1 .
16269451	0	hormone-sensitive_lipase	80,104	specificity_protein-1	128,149	hormone-sensitive lipase	specificity protein-1	3991	6667	Gene	Gene	START_ENTITY|nmod|involvement involvement|nmod|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma transcriptionally up-regulates hormone-sensitive_lipase via the involvement of specificity_protein-1 .
23201148	0	hormone/receptor	65,81	MC2_receptor	115,127	hormone/receptor	MC2 receptor	3164	4158	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|END_ENTITY	Using the human melanocortin-2 receptor as a model for analyzing hormone/receptor interactions between a mammalian MC2_receptor and ACTH -LRB- 1-24 -RRB- .
19666946	0	hormone_receptor	83,99	HER-2	0,5	hormone receptor	HER-2	3164	2064	Gene	Gene	expression|compound|START_ENTITY shows|dobj|expression shows|nsubj|protein protein|compound|END_ENTITY	HER-2 protein overexpressing breast_cancer without gene amplification shows higher hormone_receptor expression than HER-2 protein overexpressing breast_cancer with gene amplification .
19666946	0	hormone_receptor	83,99	HER-2	116,121	hormone receptor	HER-2	3164	2064	Gene	Gene	expression|compound|START_ENTITY shows|dobj|expression shows|nmod|protein protein|compound|END_ENTITY	HER-2 protein overexpressing breast_cancer without gene amplification shows higher hormone_receptor expression than HER-2 protein overexpressing breast_cancer with gene amplification .
20138441	0	hormone_receptor	38,54	HER-2	20,25	hormone receptor	HER-2	3164	2064	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Concordance between HER-2 and steroid hormone_receptor expression between primary breast_cancer , sentinel node metastases , and isolated_tumor cells .
2332411	0	hormone_sensitive_lipase	65,89	tumor_necrosis_factor	21,42	hormone sensitive lipase	tumor necrosis factor	3991	7124	Gene	Gene	expression|nmod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Inhibitory effect of tumor_necrosis_factor on gene expression of hormone_sensitive_lipase in 3T3-L1 adipocytes .
8661027	0	host_cell_factor	29,45	HCFC1	49,54	host cell factor	HCFC1	3054	3054	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The complete sequence of the host_cell_factor 1 -LRB- HCFC1 -RRB- gene and its promoter : a role for YY1 transcription factor in the regulation of its expression .
8833156	0	host_cell_factor	61,77	HCFC1	84,89	host cell factor	HCFC1	3054	3054	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The chromosome localization and the HCF repeats of the human host_cell_factor gene -LRB- HCFC1 -RRB- are conserved in the mouse homologue .
16019559	0	hoxC4	12,17	CD14	26,30	hoxC4	CD14	3221	929	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Upregulated hoxC4 induces CD14 expression during the differentiation of acute_promyelocytic_leukemia cells .
24809472	0	hoxa9	73,78	meis1	66,71	hoxa9	meis1	15405(Tax:10090)	17268(Tax:10090)	Gene	Gene	leukemogenesis|amod|START_ENTITY onset|dep|leukemogenesis onset|nmod|END_ENTITY	The deficiency of tumor suppressor prep1 accelerates the onset of meis1 - hoxa9 leukemogenesis .
8824508	0	hprt	76,80	hypoxanthine_phosphoribosyltransferase	36,74	hprt	hypoxanthine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Spectrum of somatic mutation at the hypoxanthine_phosphoribosyltransferase -LRB- hprt -RRB- gene of healthy people .
9435878	0	hprt	96,100	hypoxanthine_phosphoribosyltransferase	56,94	hprt	hypoxanthine phosphoribosyltransferase	3251	3251	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion and insertion in vivo somatic mutations in the hypoxanthine_phosphoribosyltransferase -LRB- hprt -RRB- gene of human T-lymphocytes .
9811450	0	hpttg	0,5	pttg	32,36	hpttg	pttg	9232	64193(Tax:10116)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	hpttg , a human homologue of rat pttg , is overexpressed in hematopoietic_neoplasms .
10484292	0	hsRPB7	64,70	RAR	12,15	hsRPB7	RAR	5436	5914	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Ligand-free RAR can interact with the RNA polymerase II subunit hsRPB7 and repress transcription .
19074828	0	hsa-miR-10a	19,30	CD34	59,63	hsa-miR-10a	CD34	406902	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Down-regulation of hsa-miR-10a in chronic_myeloid_leukemia CD34 + cells increases USF2-mediated cell growth .
23527115	0	hsa-miR-148a	18,30	PXR	50,53	hsa-miR-148a	PXR	406940	8856	Gene	Gene	correlation|nmod|START_ENTITY correlation|nmod|END_ENTITY	No correlation of hsa-miR-148a with expression of PXR or CYP3A4 in human livers from Chinese Han population .
25280995	0	hsa-miR-432	30,41	Heat_shock_factor_1	0,19	hsa-miR-432	Heat shock factor 1	574451	3297	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Heat_shock_factor_1 regulates hsa-miR-432 expression in human cervical_cancer cell line .
26917489	0	hsa-miR-448	112,123	MALAT1	68,74	hsa-miR-448	MALAT1	554212	378938	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|compound|END_ENTITY	Aberrant KDM5B expression promotes aggressive breast_cancer through MALAT1 overexpression and downregulation of hsa-miR-448 .
18341654	0	hsc70	75,80	CD4	5,8	hsc70	CD4	15481(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|appos|START_ENTITY +|compound|END_ENTITY	Both CD4 + and CD8 + T cell epitopes fused to heat_shock cognate protein 70 -LRB- hsc70 -RRB- can function to eradicate tumors .
7988690	0	hsc70	4,9	hsp70	91,96	hsc70	hsp70	3312	3308	Gene	Gene	gene|amod|START_ENTITY member|nsubj|gene member|nmod|family family|amod|END_ENTITY	The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family .
3285177	0	hsc70	126,131	p53	153,156	hsc70	p53	24468(Tax:10116)	22060(Tax:10090)	Gene	Gene	dissociation|nmod|START_ENTITY dissociation|nmod|END_ENTITY	Purification of complexes of nuclear oncogene p53 with rat and Escherichia_coli heat_shock proteins : in vitro dissociation of hsc70 and dnaK from murine p53 by ATP .
9249195	0	hsc_70	14,20	hsp_70	30,36	hsc 70	hsp 70	3312	3308	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of hsc_70 , but not hsp_70 , in human third molar dental pulp .
9649220	0	hsp	56,59	heat_shock_protein	36,54	hsp	heat shock protein	7190	7190	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Circulating antibodies to the 60-kD heat_shock_protein -LRB- hsp -RRB- family in patients with Helicobacter_pylori_infection .
7743197	0	hsp-70	34,40	c-fos	14,19	hsp-70	c-fos	266759(Tax:10116)	314322(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Expression of c-fos and inducible hsp-70 mRNA following a transient episode of focal ischemia that had non-lethal effects on the rat brain .
16861019	0	hsp110	62,68	heat_shock_protein	37,55	hsp110	heat shock protein	446527(Tax:8355)	398343(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Examination of the expression of the heat_shock_protein gene , hsp110 , in Xenopus_laevis cultured cells and embryos .
12603322	0	hsp25	72,77	heat_shock_protein_with_molecular_mass_25_kDa	25,70	hsp25	heat shock protein with molecular mass 25 kDa	3315	3315	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the small heat_shock_protein_with_molecular_mass_25_kDa -LRB- hsp25 -RRB- with actin .
16571921	0	hsp25	26,31	hsp70	45,50	hsp25	hsp70	24471(Tax:10116)	266759(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	p27Cip/Kip is involved in hsp25 or inducible hsp70 mediated adaptive response by low dose radiation .
11546764	0	hsp27	57,62	ARA55	45,50	hsp27	ARA55	3315	7041	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Identification and characterization of hic-5 / ARA55 as an hsp27 binding protein .
8526844	0	hsp27	87,92	heat-shock_protein_27	64,85	hsp27	heat-shock protein 27	3315	3315	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Intracellular reactive oxygen species as apparent modulators of heat-shock_protein_27 -LRB- hsp27 -RRB- structural organization and phosphorylation in basal and tumour_necrosis factor alpha-treated T47D human carcinoma cells .
2304467	0	hsp28	92,97	Tumor_necrosis_factor	0,21	hsp28	Tumor necrosis factor	3315	7124	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Tumor_necrosis_factor induces the rapid phosphorylation of the mammalian heat_shock protein hsp28 .
9774392	0	hsp40	68,73	Hsp70	28,33	hsp40	Hsp70	3337	3308	Gene	Gene	Sis1|amod|START_ENTITY modified|nmod|Sis1 modified|nsubjpass|activity activity|nmod|END_ENTITY	Protein folding activity of Hsp70 is modified differentially by the hsp40 co-chaperones Sis1 and Ydj1 .
8990167	0	hsp40	24,29	P58IPK	56,62	hsp40	P58IPK	171221	5611	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|nmod|END_ENTITY	The molecular chaperone hsp40 regulates the activity of P58IPK , the cellular inhibitor of PKR .
7641298	0	hsp40	38,43	hsp70	56,61	hsp40	hsp70	171221	3308	Gene	Gene	Cotranslocation|nmod|START_ENTITY Cotranslocation|nmod|END_ENTITY	Cotranslocation and colocalization of hsp40 -LRB- DnaJ -RRB- with hsp70 -LRB- DnaK -RRB- in mammalian cells .
10023073	0	hsp47	41,46	CBP2	53,57	hsp47	CBP2	871	871	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human genome has only one functional hsp47 gene -LRB- CBP2 -RRB- and a pseudogene -LRB- pshsp47 -RRB- .
1922029	0	hsp56	95,100	hsp90	88,93	hsp56	hsp90	8991	3320	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Progesterone enhances target gene transcription by receptor free of heat_shock proteins hsp90 , hsp56 , and hsp70 .
7905878	1	hsp60	166,171	MCAD	139,143	hsp60	MCAD	3329	34	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Demonstration of impaired transfer of K304E-variant MCAD from its complex with hsp60 to the native tetramer .
9243807	0	hsp60	71,76	heat_shock_chaperonin_protein	40,69	hsp60	heat shock chaperonin protein	3329	3329	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cell surface localization of the 60 kDa heat_shock_chaperonin_protein -LRB- hsp60 -RRB- in mammalian cells .
18950664	0	hsp65	127,132	heat_shock_protein_65	104,125	hsp65	heat shock protein 65	3329	3329	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Comparative evaluation of Polymerase Chain Reaction-Restriction Enzyme Analysis -LRB- PRA -RRB- and sequencing of heat_shock_protein_65 -LRB- hsp65 -RRB- gene for identification of aquatic mycobacteria .
1628823	0	hsp70	29,34	HSF	50,53	hsp70	HSF	3308	3569	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The human heat shock protein hsp70 interacts with HSF , the transcription factor that regulates heat shock gene expression .
10224227	0	hsp70	80,85	HSF1	54,58	hsp70	HSF1	3308	3297	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70 .
19754877	0	hsp70	23,28	Hsp105beta	0,10	hsp70	Hsp105beta	3308	10808	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Hsp105beta upregulates hsp70 gene expression through signal_transducer_and_activator_of_transcription-3 .
15777846	0	hsp70	39,44	Hsp90	0,5	hsp70	Hsp90	3308	3320	Gene	Gene	stabilisation|amod|START_ENTITY increases|dobj|stabilisation increases|nsubj|geldanamycin geldanamycin|amod|END_ENTITY	Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic_pressure .
7859920	0	hsp70	34,39	heat-shock_protein	14,32	hsp70	heat-shock protein	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of heat-shock_protein -LRB- hsp70 -RRB- gene expression by hGH and IL2 in rat Nb2 lymphoma cells .
24708778	0	hsp70	98,103	heat_shock_protein_70	75,96	hsp70	heat shock protein 70	3308	3308	Gene	Gene	response|appos|START_ENTITY response|amod|END_ENTITY	Effect of multiple microsporidian infections and temperature stress on the heat_shock_protein_70 -LRB- hsp70 -RRB- response of the amphipod Gammarus pulex .
7788642	0	hsp70	69,74	heat_shock_protein_70	46,67	hsp70	heat shock protein 70	266759(Tax:10116)	266759(Tax:10116)	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Selective postmortem degradation of inducible heat_shock_protein_70 -LRB- hsp70 -RRB- mRNAs in rat brain .
7988690	0	hsp70	91,96	hsc70	4,9	hsp70	hsc70	3308	3312	Gene	Gene	family|amod|START_ENTITY member|nmod|family member|nsubj|gene gene|amod|END_ENTITY	The hsc70 gene which is slightly induced by heat is the main virus inducible member of the hsp70 gene family .
16571921	0	hsp70	45,50	hsp25	26,31	hsp70	hsp25	266759(Tax:10116)	24471(Tax:10116)	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	p27Cip/Kip is involved in hsp25 or inducible hsp70 mediated adaptive response by low dose radiation .
7641298	0	hsp70	56,61	hsp40	38,43	hsp70	hsp40	3308	171221	Gene	Gene	Cotranslocation|nmod|START_ENTITY Cotranslocation|nmod|END_ENTITY	Cotranslocation and colocalization of hsp40 -LRB- DnaJ -RRB- with hsp70 -LRB- DnaK -RRB- in mammalian cells .
10764743	1	hsp70	128,133	hsp90	47,52	hsp70	hsp90	3308	3320	Gene	Gene	events|nmod|START_ENTITY resolves|dobj|events resolves|nsubj|heterocomplex heterocomplex|amod|END_ENTITY	hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket .
11274138	0	hsp70	45,50	hsp90	22,27	hsp70	hsp90	3308	3320	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Stable association of hsp90 and p23 , but Not hsp70 , with active human telomerase .
8106480	0	hsp70	11,16	hsp90	99,104	hsp70	hsp90	15511(Tax:10090)	111058(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|heterocomplex heterocomplex|nmod|END_ENTITY	Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90 .
8836160	0	hsp70	34,39	hsp90	149,154	hsp70	hsp90	542820(Tax:4565)	104434(Tax:10090)	Gene	Gene	family|amod|START_ENTITY members|nmod|family Ability|nmod|members Ability|acl|promote promote|nmod|heterocomplex heterocomplex|nmod|END_ENTITY	Ability of various members of the hsp70 family of chaperones to promote assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90 .
1567424	0	hsp70	0,5	p53	93,96	hsp70	p53	3308	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|peptide peptide|acl|derived derived|nmod|region region|nmod|END_ENTITY	hsp70 binds specifically to a peptide derived from the highly conserved domain -LRB- I -RRB- region of p53 .
7828728	0	hsp70	20,25	p53	115,118	hsp70	p53	3308	7157	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	Interaction between hsp70 and hsp40 , eukaryotic homologues of DnaK and DnaJ , in human cells expressing mutant-type p53 .
8418500	0	hsp70	24,29	p53	42,45	hsp70	p53	3308	7157	Gene	Gene	promoter|amod|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the human hsp70 promoter by p53 .
12391142	0	hsp72	19,24	apoptosis_signal-regulating_kinase_1	52,88	hsp72	apoptosis signal-regulating kinase 1	193740(Tax:10090)	26408(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Heat_shock protein hsp72 is a negative regulator of apoptosis_signal-regulating_kinase_1 .
23874968	0	hsp72	47,52	heat_shock_protein-70	24,45	hsp72	heat shock protein-70	3303	3303	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of inducible heat_shock_protein-70 -LRB- hsp72 -RRB- enhances bortezomib-induced cell death in human bladder_cancer cells .
10464705	0	hsp72	63,68	p53	127,130	hsp72	p53	193740(Tax:10090)	22060(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY apoptosis|nmod|proteins incidence|nmod|apoptosis L|nsubj|incidence L|nmod|status status|nmod|gene gene|compound|END_ENTITY	Thermosensitivity , incidence of apoptosis and accumulations of hsp72 and p53 proteins of murine L cells in wild type status of p53 gene .
9696931	0	hsp72	49,54	p53	14,17	hsp72	p53	3303	7157	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of p53 , bcl-2 and heat_shock_protein -LRB- hsp72 -RRB- in malignant_and_benign_ovarian_tumours .
11812147	0	hsp90	49,54	ATPase	24,30	hsp90	ATPase	3320	1769	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Stimulation of the weak ATPase activity of human hsp90 by a client protein .
23202271	0	hsp90	110,115	Act1	53,57	hsp90	Act1	111058(Tax:10090)	109776(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 .
10898951	0	hsp90	86,91	CYP2E1	0,6	hsp90	CYP2E1	3320	1571	Gene	Gene	role|nmod|START_ENTITY degradation|dep|role degradation|compound|END_ENTITY	CYP2E1 degradation by in vitro reconstituted systems : role of the molecular chaperone hsp90 .
16478993	0	hsp90	60,65	GCUNC-45	0,8	hsp90	GCUNC-45	3320	55898	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	GCUNC-45 is a novel regulator for the progesterone_receptor / hsp90 chaperoning pathway .
3036833	0	hsp90	121,126	GRP94	170,175	hsp90	GRP94	3320	7184	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	ERp99 , an abundant , conserved glycoprotein of the endoplasmic reticulum , is homologous to the 90-kDa heat_shock protein -LRB- hsp90 -RRB- and the 94-kDa_glucose_regulated_protein -LRB- GRP94 -RRB- .
18591380	0	hsp90	57,62	HDAC6	0,5	hsp90	HDAC6	3320	10013	Gene	Gene	chaperone|amod|START_ENTITY abrogation|nmod|chaperone function|nsubj|abrogation enhances|parataxis|function enhances|nsubj|inhibition inhibition|compound|END_ENTITY	HDAC6 inhibition enhances 17-AAG -- mediated abrogation of hsp90 chaperone function in human leukemia cells .
18820283	0	hsp90	15,20	hTERT	28,33	hsp90	hTERT	3320	7015	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral_cancer cells .
18820283	0	hsp90	15,20	hTERT	60,65	hsp90	hTERT	3320	7015	Gene	Gene	Association|nmod|START_ENTITY necessary|nsubj|Association necessary|nmod|expression expression|amod|END_ENTITY	Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral_cancer cells .
12521608	0	hsp90	37,42	heat_shock_protein_90	14,35	hsp90	heat shock protein 90	3320	3320	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of heat_shock_protein_90 -LRB- hsp90 -RRB- in proliferating endothelial cells uncouples endothelial_nitric_oxide_synthase activity .
1922029	0	hsp90	88,93	hsp56	95,100	hsp90	hsp56	3320	8991	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Progesterone enhances target gene transcription by receptor free of heat_shock proteins hsp90 , hsp56 , and hsp70 .
10764743	1	hsp90	47,52	hsp70	128,133	hsp90	hsp70	3320	3308	Gene	Gene	heterocomplex|amod|START_ENTITY resolves|nsubj|heterocomplex resolves|dobj|events events|nmod|END_ENTITY	hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket .
11274138	0	hsp90	22,27	hsp70	45,50	hsp90	hsp70	3320	3308	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	Stable association of hsp90 and p23 , but Not hsp70 , with active human telomerase .
8106480	0	hsp90	99,104	hsp70	11,16	hsp90	hsp70	111058(Tax:10090)	15511(Tax:10090)	Gene	Gene	heterocomplex|nmod|START_ENTITY required|nmod|heterocomplex required|nsubjpass|END_ENTITY	Proof that hsp70 is required for assembly of the glucocorticoid receptor into a heterocomplex with hsp90 .
8836160	0	hsp90	149,154	hsp70	34,39	hsp90	hsp70	104434(Tax:10090)	542820(Tax:4565)	Gene	Gene	heterocomplex|nmod|START_ENTITY promote|nmod|heterocomplex Ability|acl|promote Ability|nmod|members members|nmod|family family|amod|END_ENTITY	Ability of various members of the hsp70 family of chaperones to promote assembly of the glucocorticoid receptor into a functional heterocomplex with hsp90 .
15155759	0	hsp90	12,17	nitric-oxide_synthase	63,84	hsp90	nitric-oxide synthase	3320	4842	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide_synthase .
11507088	0	hsp90	22,27	p53	50,53	hsp90	p53	3320	7157	Gene	Gene	MDM2|nmod|START_ENTITY Inhibition|nmod|MDM2 contributes|nsubj|Inhibition contributes|nmod|stabilization stabilization|compound|END_ENTITY	Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization .
15145929	0	hsp90	94,99	p53	25,28	hsp90	p53	3320	7157	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation .
8404044	0	hsp90_alpha	36,47	HSPCAL4	49,56	hsp90 alpha	HSPCAL4	3320	3320	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping the intron-containing human hsp90_alpha -LRB- HSPCAL4 -RRB- gene to chromosome band 14q32 .
15284248	0	hsp90beta	14,23	p53	32,35	hsp90beta	p53	3326	7157	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells .
17069861	0	hsp_27	20,26	TNF-alpha	0,9	hsp 27	TNF-alpha	3315	7124	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	TNF-alpha decreases hsp_27 in human blood mononuclear cells : involvement of protein kinase c. Treatment of PBMCs with TNF-alpha decreased the levels of heat_shock protein -LRB- HSP -RRB- 27 , but had little effect on the level of HSP70 .
9249195	0	hsp_70	30,36	hsc_70	14,20	hsp 70	hsc 70	3308	3312	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of hsc_70 , but not hsp_70 , in human third molar dental pulp .
12692162	0	htr1A	73,78	serotonin_receptor_1A	45,66	htr1A	serotonin receptor 1A	487230(Tax:9615)	487230(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the canine serotonin_receptor_1A gene -LRB- htr1A -RRB- .
16251523	0	htr1A	123,128	serotonin_receptor_1A	95,116	htr1A	serotonin receptor 1A	487230(Tax:9615)	487230(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and variation of three canine genes involved in serotonin binding and transport : the serotonin_receptor_1A gene -LRB- htr1A -RRB- , serotonin_receptor_2A gene -LRB- htr2A -RRB- , and serotonin transporter gene -LRB- slc6A4 -RRB- .
14729271	0	htr1B	73,78	serotonin_receptor_1B	45,66	htr1B	serotonin receptor 1B	403741(Tax:9615)	403741(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Isolation and characterization of the canine serotonin_receptor_1B gene -LRB- htr1B -RRB- .
16251523	0	htr2A	159,164	serotonin_receptor_2A	131,152	htr2A	serotonin receptor 2A	403882(Tax:9615)	403882(Tax:9615)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and variation of three canine genes involved in serotonin binding and transport : the serotonin_receptor_1A gene -LRB- htr1A -RRB- , serotonin_receptor_2A gene -LRB- htr2A -RRB- , and serotonin transporter gene -LRB- slc6A4 -RRB- .
24117884	0	hub	11,14	GSTP1	0,5	hub	GSTP1	1993	2950	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	GSTP1 is a hub gene for gene-air pollution interactions on childhood asthma .
12672042	0	human_cachexia-associated_protein	18,51	HCAP	53,57	human cachexia-associated protein	HCAP	117159	117159	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the human_cachexia-associated_protein -LRB- HCAP -RRB- in prostate_cancer and in a prostate_cancer animal model of cachexia .
21724847	0	human_epidermal_growth_factor_receptor_2	21,61	IQGAP1	0,6	human epidermal growth factor receptor 2	IQGAP1	2064	8826	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|protein protein|compound|END_ENTITY	IQGAP1 protein binds human_epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- and modulates trastuzumab resistance .
26575020	0	human_epididymis_protein_4	23,49	HE4	18,21	human epididymis protein 4	HE4	10406	10406	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of HE4 -LRB- human_epididymis_protein_4 -RRB- enhances proliferation , invasion and metastasis of ovarian_cancer .
16954503	0	human_germinal_center-associated_lymphoma	18,59	HGAL	61,65	human germinal center-associated lymphoma	HGAL	257144	257144	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of the human_germinal_center-associated_lymphoma -LRB- HGAL -RRB- protein identifies a subset of classic Hodgkin_lymphoma of germinal center derivation and improved survival .
21447067	0	human_germinal_center_associated_lymphoma	33,74	myosin	104,110	human germinal center associated lymphoma	myosin	257144	79784	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Germinal center-specific protein human_germinal_center_associated_lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin .
19692629	0	human_leukocyte_antigen-G	15,40	HLA-G	42,47	human leukocyte antigen-G	HLA-G	3135	3135	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Correlation of human_leukocyte_antigen-G -LRB- HLA-G -RRB- expression and disease progression in epithelial ovarian_cancer .
21609580	0	human_leukocyte_antigen-G	12,37	p38	41,44	human leukocyte antigen-G	p38	3135	1432	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	-LSB- Effects of human_leukocyte_antigen-G on p38 mitogen-activated protein kinase signaling pathway in HTR-8 / SVneo cell line -RSB- .
2322278	0	human_leukocyte_elastase	25,49	medullasin	56,66	human leukocyte elastase	medullasin	1991	1991	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Functional expression of human_leukocyte_elastase -LRB- HLE -RRB- / medullasin in eukaryotic cells .
12860370	0	human_opposite_paired	49,70	HOPA	72,76	human opposite paired	HOPA	9968	9968	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association of a dodecamer duplication in the human_opposite_paired -LRB- HOPA -RRB- gene with mental_retardation and schizophrenia in Chinese patients from Taiwan .
22240898	0	huntingtin	25,35	ATRX	0,4	huntingtin	ATRX	43392(Tax:7227)	43080(Tax:7227)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington 's _ disease .
11172033	0	huntingtin	66,76	CA150	45,50	huntingtin	CA150	3064	10915	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin : neuropathologic and genetic evidence for a role in Huntington 's _ disease pathogenesis .
22649225	0	huntingtin	76,86	Caspase-6	0,9	huntingtin	Caspase-6	15194(Tax:10090)	12368(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY levels|nmod|protein modulates|dobj|levels modulates|nsubj|activity activity|amod|END_ENTITY	Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino_acid proteolytic fragment .
15911879	0	huntingtin	24,34	Cdk5	0,4	huntingtin	Cdk5	15194(Tax:10090)	12568(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases : implications for mutant huntingtin toxicity .
15911879	0	huntingtin	93,103	Cdk5	0,4	huntingtin	Cdk5	15194(Tax:10090)	12568(Tax:10090)	Gene	Gene	toxicity|compound|START_ENTITY implications|nmod|toxicity reduces|parataxis|implications reduces|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases : implications for mutant huntingtin toxicity .
25041730	0	huntingtin	7,17	Gab1	27,31	huntingtin	Gab1	3064	2549	Gene	Gene	replaces|nsubj|START_ENTITY replaces|dobj|END_ENTITY	Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth_factor_receptor_binding_protein_2 -LRB- Grb2 -RRB- .
16192271	0	huntingtin	77,87	HDAC6	0,5	huntingtin	HDAC6	3064	10013	Gene	Gene	degradation|nmod|START_ENTITY required|nmod|degradation required|nsubjpass|END_ENTITY	HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin .
19525941	0	huntingtin	11,21	JNK3	67,71	huntingtin	JNK3	15194(Tax:10090)	26414(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin .
12354780	0	huntingtin	24,34	PACSIN_1	0,8	huntingtin	PACSIN 1	3064	29993	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PACSIN_1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington 's _ disease brains .
18845944	0	huntingtin	14,24	Rab11	59,64	huntingtin	Rab11	15194(Tax:10090)	53869(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	A function of huntingtin in guanine_nucleotide exchange on Rab11 .
22399227	0	huntingtin	20,30	Sp1	0,3	huntingtin	Sp1	3064	6667	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sp1 regulates human huntingtin gene expression .
21454471	0	huntingtin	75,85	Tumor_necrosis_factor_receptor-associated_factor_6	0,50	huntingtin	Tumor necrosis factor receptor-associated factor 6	3064	22034(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Tumor_necrosis_factor_receptor-associated_factor_6 -LRB- TRAF6 -RRB- associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation .
16777606	0	huntingtin	99,109	caspase-6	16,25	huntingtin	caspase-6	15194(Tax:10090)	12368(Tax:10090)	Gene	Gene	due|nmod|START_ENTITY neuronal_dysfunction|amod|due required|nmod|neuronal_dysfunction required|nsubjpass|Cleavage Cleavage|nmod|site site|amod|END_ENTITY	Cleavage at the caspase-6 site is required for neuronal_dysfunction and degeneration due to mutant huntingtin .
18445618	0	huntingtin	55,65	caspase-6	10,19	huntingtin	caspase-6	15194(Tax:10090)	12368(Tax:10090)	Gene	Gene	fragments|nmod|START_ENTITY fragments|amod|END_ENTITY	Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus .
21068307	0	huntingtin	56,66	caspase-6	31,40	huntingtin	caspase-6	3064	839	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Cleavage at the 586 amino_acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo .
21068307	0	huntingtin	56,66	caspase-6	78,87	huntingtin	caspase-6	3064	839	Gene	Gene	site|nmod|START_ENTITY Cleavage|nmod|site influences|nsubj|Cleavage influences|dobj|activation activation|amod|END_ENTITY	Cleavage at the 586 amino_acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo .
24070868	0	huntingtin	85,95	caspase-6	14,23	huntingtin	caspase-6	15194(Tax:10090)	12368(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY tissue|acl|expressing increases|nmod|tissue increases|dobj|expression expression|amod|END_ENTITY	p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin .
23251447	0	huntingtin	21,31	leptin	35,41	huntingtin	leptin	15194(Tax:10090)	16846(Tax:10090)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse .
10974549	0	huntingtin-associated_protein	6,35	HAP-1	37,42	huntingtin-associated protein	HAP-1	9001	9001	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human huntingtin-associated_protein -LRB- HAP-1 -RRB- gene : genomic organisation and an intragenic polymorphism .
10585161	0	huntingtin-interacting_protein-2	16,48	Hip-2	50,55	huntingtin-interacting protein-2	Hip-2	53323(Tax:10090)	53323(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of huntingtin-interacting_protein-2 -LRB- Hip-2 -RRB- mRNA in the developing mouse brain .
22203674	0	hyaluronan-mediated_motility_receptor	77,114	HMMR	116,120	hyaluronan-mediated motility receptor	HMMR	3161	3161	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mechanism of MTA1 protein overexpression-linked invasion : MTA1 regulation of hyaluronan-mediated_motility_receptor -LRB- HMMR -RRB- expression and function .
16604446	0	hyaluronan-mediated_motility_receptor	28,65	RHAMM	67,72	hyaluronan-mediated motility receptor	RHAMM	3161	3161	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A gene similar to the human hyaluronan-mediated_motility_receptor -LRB- RHAMM -RRB- gene is upregulated during Porcine_Circovirus_type_2 infection .
20953637	0	hyaluronan_and_proteoglycan_link_protein_1	38,80	HAPLN1	82,88	hyaluronan and proteoglycan link protein 1	HAPLN1	1404	1404	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single-nucleotide polymorphism in the hyaluronan_and_proteoglycan_link_protein_1 -LRB- HAPLN1 -RRB- gene is associated with spinal osteophyte formation and disc_degeneration in Japanese women .
18815290	0	hyaluronan_synthase_1	41,62	HAS1	64,68	hyaluronan synthase 1	HAS1	3036	3036	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inherited and acquired variations in the hyaluronan_synthase_1 -LRB- HAS1 -RRB- gene may contribute to disease progression in multiple_myeloma and Waldenstrom_macroglobulinemia .
26521733	0	hyaluronan_synthase_1	14,35	Has1	37,41	hyaluronan synthase 1	Has1	15116(Tax:10090)	15116(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Deficiency of hyaluronan_synthase_1 -LRB- Has1 -RRB- results in chronic_joint_inflammation and widespread intra-articular fibrosis in a murine model of knee joint cartilage_damage .
11262389	0	hyaluronan_synthase_2	34,55	Epidermal_growth_factor	0,23	hyaluronan synthase 2	Epidermal growth factor	25694(Tax:10116)	25313(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Epidermal_growth_factor activates hyaluronan_synthase_2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan .
21357421	0	hyaluronan_synthase_2	10,31	HAS2	33,37	hyaluronan synthase 2	HAS2	3037	3037	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human hyaluronan_synthase_2 -LRB- HAS2 -RRB- gene and its natural antisense RNA exhibit coordinated expression in the renal proximal tubular epithelial cell .
24847057	0	hyaluronan_synthase_2	160,181	HAS2	183,187	hyaluronan synthase 2	HAS2	3037	3037	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Extracellular UDP-glucose activates P2Y14_Receptor and Induces Signal_Transducer_and_Activator_of_Transcription_3 -LRB- STAT3 -RRB- Tyr705 phosphorylation and binding to hyaluronan_synthase_2 -LRB- HAS2 -RRB- promoter , stimulating hyaluronan synthesis of keratinocytes .
12186949	0	hyaluronan_synthase_2	147,168	Has2	170,174	hyaluronan synthase 2	Has2	3037	3037	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Changed lamellipodial extension , adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan_synthase_2 -LRB- Has2 -RRB- genes .
10803777	0	hyaluronate_receptor	29,49	CD44	51,55	hyaluronate receptor	CD44	960	960	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of hyaluronate_receptor -LRB- CD44 -RRB- in alcoholic liver_disease .
20960509	0	hyaluronic_acid_family_members	15,45	HAS1	47,51	hyaluronic acid family members	HAS1	3036	3036	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association of hyaluronic_acid_family_members -LRB- HAS1 , HAS2 , and HYAL-1 -RRB- with bladder_cancer diagnosis and prognosis .
14752026	0	hyaluronic_acid_synthase_2	13,39	HAS2	41,45	hyaluronic acid synthase 2	HAS2	3037	3037	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of hyaluronic_acid_synthase_2 -LRB- HAS2 -RRB- in human vascular smooth muscle cells by vasodilatory prostaglandins .
21695196	0	hyaluronidase-1	40,55	HYAL-1	57,63	hyaluronidase-1	HYAL-1	3373	3373	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Subtype specific elevated expression of hyaluronidase-1 -LRB- HYAL-1 -RRB- in epithelial_ovarian_cancer .
3265677	0	hybridoma_growth_factor	13,36	IL-6	57,61	hybridoma growth factor	IL-6	3569	3569	Gene	Gene	Induction|nmod|START_ENTITY Induction|amod|END_ENTITY	Induction of hybridoma_growth_factor -LRB- HGF -RRB- , identical to IL-6 , in human fibroblasts by IL-1 : use of HGF activity in specific and sensitive biological assays for IL-1 and IL-6 .
3349651	0	hybridoma_growth_factor	33,56	interleukin_6	58,71	hybridoma growth factor	interleukin 6	3569	3569	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated levels of the 26K human hybridoma_growth_factor -LRB- interleukin_6 -RRB- in cerebrospinal fluid of patients with acute_infection_of_the_central_nervous_system .
3267012	0	hybridoma_suppressor_factor	6,33	CD4	54,57	hybridoma suppressor factor	CD4	3569	920	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|cells cells|compound|END_ENTITY	Human hybridoma_suppressor_factor acts selectively on CD4 + cells .
7087670	0	hydroxy-indole-o-methyl-transferase	34,69	HIOMT	71,76	hydroxy-indole-o-methyl-transferase	HIOMT	438	438	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of avian and mammalian hydroxy-indole-o-methyl-transferase -LRB- HIOMT -RRB- with low molecular weight fractions of mammalian pineal glands .
15117945	0	hydroxyacylglutathione_hydrolase	10,42	HAGH	44,48	hydroxyacylglutathione hydrolase	HAGH	3029	3029	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Human hydroxyacylglutathione_hydrolase -LRB- HAGH -RRB- gene encodes both cytosolic and mitochondrial forms of glyoxalase_II .
25881750	0	hydroxycarboxylic_acid_receptor_1	52,85	G-protein-coupled_receptor_81	22,51	hydroxycarboxylic acid receptor 1	G-protein-coupled receptor 81	27198	27198	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	The lactate receptor , G-protein-coupled_receptor_81 / hydroxycarboxylic_acid_receptor_1 : Expression and action in brain .
6180129	0	hydroxyindole-O-methyl_transferase	40,74	HIOMT	76,81	hydroxyindole-O-methyl transferase	HIOMT	246281(Tax:10116)	246281(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Changes in the circadian rhythmicity of hydroxyindole-O-methyl_transferase -LRB- HIOMT -RRB- activity in the synthesis of 5-methoxyindoles in the pineal gland of 28 day old male Wistar_rats exposed to white , red and green light .
10067865	0	hydroxyindole-O-methyltransferase	37,70	HIOMT	72,77	hydroxyindole-O-methyltransferase	HIOMT	246281(Tax:10116)	246281(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase -LRB- HIOMT -RRB- messenger ribonucleic acid expression : an analysis of its complex relationship with HIOMT activity .
10831155	0	hydroxyindole-O-methyltransferase	17,50	HIOMT	52,57	hydroxyindole-O-methyltransferase	HIOMT	438	438	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Demonstration of hydroxyindole-O-methyltransferase -LRB- HIOMT -RRB- mRNA expression in pineal_parenchymal_tumors : histochemical in situ hybridization .
11471145	0	hydroxyindole-o-methyltransferase	35,68	HIOMT	70,75	hydroxyindole-o-methyltransferase	HIOMT	438	438	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of hydroxyindole-o-methyltransferase -LRB- HIOMT -RRB- in the brain of Myoisophagos lacteus -LRB- Nemertea : Heteronemertea : Lineidae -RRB- .
10790212	0	hydroxymethylbilane_synthase	26,54	HMBS	56,60	hydroxymethylbilane synthase	HMBS	3145	3145	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the hydroxymethylbilane_synthase -LRB- HMBS -RRB- gene in Italian patients with acute intermittent porphyria : report of four novel mutations .
15840574	0	hydroxypyruvate_reductase	94,119	glyoxylate_reductase	73,93	hydroxypyruvate reductase	glyoxylate reductase	9380	9380	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate_reductase / hydroxypyruvate_reductase gene by the peroxisome_proliferator-activated_receptor_alpha .
12153137	0	hydroxysteroid_dehydrogenase_like_1	14,49	HSDL1	56,61	hydroxysteroid dehydrogenase like 1	HSDL1	83693	83693	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel human hydroxysteroid_dehydrogenase_like_1 gene -LRB- HSDL1 -RRB- is highly expressed in reproductive tissues .
19026618	0	hydroxysteroid_dehydrogenase_like_1	20,55	HSDL1	57,62	hydroxysteroid dehydrogenase like 1	HSDL1	494064(Tax:7955)	494064(Tax:7955)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Human and zebrafish hydroxysteroid_dehydrogenase_like_1 -LRB- HSDL1 -RRB- proteins are inactive enzymes but conserved among species .
19491197	0	hypermethylated_in_cancer_1	26,53	E2F1	88,92	hypermethylated in cancer 1	E2F1	3090	1869	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The tumor suppressor gene hypermethylated_in_cancer_1 is transcriptionally regulated by E2F1 .
22184117	0	hypermethylated_in_cancer_1	62,89	EphA2	29,34	hypermethylated in cancer 1	EphA2	3090	1969	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated_in_cancer_1 -LRB- HIC1 -RRB- .
10400919	0	hyperpolarization-activated_cation_channel	31,73	HCN	75,78	hyperpolarization-activated cation channel	HCN	100009452(Tax:9986)	100009452(Tax:9986)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Distribution and prevalence of hyperpolarization-activated_cation_channel -LRB- HCN -RRB- mRNA expression in cardiac tissues .
1678246	0	hypoxanthine-guanine_phosphoribosyltransferase	30,76	HPRT	78,82	hypoxanthine-guanine phosphoribosyltransferase	HPRT	3251	3251	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Fine structure mapping of the hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- gene region of the human X chromosome -LRB- Xq26 -RRB- .
1970211	0	hypoxanthine-guanine_phosphoribosyltransferase	53,99	HPRT	101,105	hypoxanthine-guanine phosphoribosyltransferase	HPRT	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Bam HI restriction fragment length polymorphisms for hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- gene of carriers and controls of HPRT_deficiency in Japan .
2018042	0	hypoxanthine-guanine_phosphoribosyltransferase	65,111	HPRT	113,117	hypoxanthine-guanine phosphoribosyltransferase	HPRT	3251	3251	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Identification of 17 independent mutations responsible for human hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- deficiency .
8314557	0	hypoxanthine-guanine_phosphoribosyltransferase	99,145	HPRT	147,151	hypoxanthine-guanine phosphoribosyltransferase	HPRT	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of two new nucleotide mutations -LRB- HPRTUtrecht and HPRTMadrid -RRB- in exon 3 of the human hypoxanthine-guanine_phosphoribosyltransferase -LRB- HPRT -RRB- gene .
9003484	0	hypoxanthine_phosphoribosyltransferase	59,97	HPRT	99,103	hypoxanthine phosphoribosyltransferase	HPRT	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An asymptomatic germline missense base substitution in the hypoxanthine_phosphoribosyltransferase -LRB- HPRT -RRB- gene that reduces the amount of enzyme in humans .
9799086	0	hypoxanthine_phosphoribosyltransferase	146,184	HPRT	186,190	hypoxanthine phosphoribosyltransferase	HPRT	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of two deletion events involving Alu-sequences , one novel base substitution and two tentative hotspot mutations in the hypoxanthine_phosphoribosyltransferase -LRB- HPRT -RRB- gene in five patients with Lesch-Nyhan_syndrome .
11668636	0	hypoxanthine_phosphoribosyltransferase	47,85	HPRT1	87,92	hypoxanthine phosphoribosyltransferase	HPRT1	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A recurrent large Alu-mediated deletion in the hypoxanthine_phosphoribosyltransferase -LRB- HPRT1 -RRB- gene associated with Lesch-Nyhan_syndrome .
7969137	0	hypoxanthine_phosphoribosyltransferase	77,115	Hprt	117,121	hypoxanthine phosphoribosyltransferase	Hprt	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	CpG island promoter region methylation patterns of the inactive-X-chromosome hypoxanthine_phosphoribosyltransferase -LRB- Hprt -RRB- gene .
8824508	0	hypoxanthine_phosphoribosyltransferase	36,74	hprt	76,80	hypoxanthine phosphoribosyltransferase	hprt	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Spectrum of somatic mutation at the hypoxanthine_phosphoribosyltransferase -LRB- hprt -RRB- gene of healthy people .
9435878	0	hypoxanthine_phosphoribosyltransferase	56,94	hprt	96,100	hypoxanthine phosphoribosyltransferase	hprt	3251	3251	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion and insertion in vivo somatic mutations in the hypoxanthine_phosphoribosyltransferase -LRB- hprt -RRB- gene of human T-lymphocytes .
762946	0	hypoxanthineguanine-phosphoribosyltransferase	15,60	HGPRTase	62,70	hypoxanthineguanine-phosphoribosyltransferase	HGPRTase	3251	3251	Gene	Gene	Properties|nmod|START_ENTITY Properties|appos|END_ENTITY	-LSB- Properties of hypoxanthineguanine-phosphoribosyltransferase -LRB- HGPRTase -RRB- in a gout patient with partial deficiency of this enzyme -LRB- author 's transl -RRB- -RSB- .
9707622	0	hypoxia	155,162	IGFBP-1	127,134	IGFBP-1	IGFBP-1	3484	3484	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Hypoxia stimulates insulin-like_growth_factor_binding_protein_1 -LRB- IGFBP-1 -RRB- gene expression in HepG2 cells : a possible model for IGFBP-1 expression in fetal hypoxia .
21139050	0	hypoxia-induced_mitogenic_factor	17,49	HIMF	51,55	hypoxia-induced mitogenic factor	HIMF	57262(Tax:10090)	57262(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	S100A11 mediates hypoxia-induced_mitogenic_factor -LRB- HIMF -RRB- - induced smooth muscle cell migration , vesicular exocytosis , and nuclear activation .
16512910	0	hypoxia-induced_mitogenic_factor	23,55	VEGF	0,4	hypoxia-induced mitogenic factor	VEGF	57262(Tax:10090)	22339(Tax:10090)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	VEGF is upregulated by hypoxia-induced_mitogenic_factor via the PI-3K / Akt-NF-kappaB signaling pathway .
12507560	0	hypoxia-inducible_factor-1	40,66	HIF-1	68,73	hypoxia-inducible factor-1	HIF-1	3091	3091	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	The von_Hippel-Lindau_tumor suppressor , hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- degradation , and cancer pathogenesis .
17190448	0	hypoxia-inducible_factor-1	103,129	HIF-1	131,136	hypoxia-inducible factor-1	HIF-1	3091	3091	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Sodwanone and yardenone_triterpenes from a South African species of the marine sponge Axinella inhibit hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- activation in both breast_and_prostate_tumor cells .
19091749	0	hypoxia-inducible_factor-1	33,59	HIF-1	61,66	hypoxia-inducible factor-1	HIF-1	3091	3091	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Methylalpinumisoflavone inhibits hypoxia-inducible_factor-1 -LRB- HIF-1 -RRB- activation by simultaneously targeting multiple pathways .
10607702	0	hypoxia-inducible_factor-1	142,168	vascular_endothelial_growth_factor	38,72	hypoxia-inducible factor-1	vascular endothelial growth factor	3091	7422	Gene	Gene	activity|amod|START_ENTITY control|nmod|activity mediates|parataxis|control mediates|nsubj|element element|nmod|gene gene|compound|END_ENTITY	Hypoxia response element of the human vascular_endothelial_growth_factor gene mediates transcriptional regulation by nitric_oxide : control of hypoxia-inducible_factor-1 activity by nitric_oxide .
16144942	0	hypoxia-inducible_factor-1	212,238	vascular_endothelial_growth_factor	149,183	hypoxia-inducible factor-1	vascular endothelial growth factor	3091	7422	Gene	Gene	regulation|amod|START_ENTITY independent|nmod|regulation independent|nsubj|secretion secretion|compound|END_ENTITY	Transcriptional profiling identifies altered intracellular labile iron homeostasis as a contributing factor to the toxicity of adaphostin : decreased vascular_endothelial_growth_factor secretion is independent of hypoxia-inducible_factor-1 regulation .
16682012	0	hypoxia-inducible_factor-1	70,96	vascular_endothelial_growth_factor	20,54	hypoxia-inducible factor-1	vascular endothelial growth factor	3091	7422	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Adenosine modulates vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1 in human glioblastoma cells .
18339855	0	hypoxia-inducible_factor-1	81,107	vascular_endothelial_growth_factor	124,158	hypoxia-inducible factor-1	vascular endothelial growth factor	3091	7422	Gene	Gene	alpha|dep|START_ENTITY stabilizes|xcomp|alpha stabilizes|xcomp|induce induce|dobj|expression expression|compound|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible_factor-1 alpha to induce vascular_endothelial_growth_factor expression .
22582814	0	hypoxia-inducible_factor-1	16,42	vascular_endothelial_growth_factor	96,130	hypoxia-inducible factor-1	vascular endothelial growth factor	3091	7422	Gene	Gene	oligodeoxynucleotides|amod|START_ENTITY Transfection|nmod|oligodeoxynucleotides suppresses|nsubj|Transfection suppresses|dobj|expression expression|nmod|END_ENTITY	Transfection of hypoxia-inducible_factor-1 decoy oligodeoxynucleotides suppresses expression of vascular_endothelial_growth_factor in oral squamous_cell_carcinoma cells .
25301555	0	hypoxia-inducible_factor-1_alpha	19,51	HEXIM1	94,100	hypoxia-inducible factor-1 alpha	HEXIM1	3091	192231(Tax:10090)	Gene	Gene	START_ENTITY|nmod|attenuates attenuates|nummod|END_ENTITY	Down-regulation of hypoxia-inducible_factor-1_alpha and vascular_endothelial_growth_factor by HEXIM1 attenuates myocardial_angiogenesis in hypoxic mice .
22350022	0	hypoxia-inducible_factor-1_alpha	36,68	HIF-1a	70,76	hypoxia-inducible factor-1 alpha	HIF-1a	3091	3091	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinicopathological significance of hypoxia-inducible_factor-1_alpha -LRB- HIF-1a -RRB- expression in gastric_cancer .
12193413	0	hypoxia-inducible_factor-1_alpha	15,47	HIF-1alpha	49,59	hypoxia-inducible factor-1 alpha	HIF-1alpha	29560(Tax:10116)	29560(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Stimulation of hypoxia-inducible_factor-1_alpha -LRB- HIF-1alpha -RRB- protein in the adult rat testis following ischemic_injury occurs without an increase in HIF-1alpha messenger RNA expression .
17848618	0	hypoxia-inducible_factor-1_alpha	157,189	HIF-1alpha	191,201	hypoxia-inducible factor-1 alpha	HIF-1alpha	3091	3091	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The new tumor-suppressor gene inhibitor of growth family member 4 -LRB- ING4 -RRB- regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible_factor-1_alpha -LRB- HIF-1alpha -RRB- activity : involvement in myeloma-induced angiogenesis .
18565696	0	hypoxia-inducible_factor-1_alpha	52,84	HIF-1alpha	86,96	hypoxia-inducible factor-1 alpha	HIF-1alpha	3091	3091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variable patterns in the molecular evolution of the hypoxia-inducible_factor-1_alpha -LRB- HIF-1alpha -RRB- gene in teleost fishes and mammals .
12632503	0	hypoxia-inducible_factor-1_alpha	37,69	PTEN	31,35	hypoxia-inducible factor-1 alpha	PTEN	3091	5728	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and significance of PTEN , hypoxia-inducible_factor-1_alpha in colorectal_adenoma and adenocarcinoma .
12193088	0	hypoxia-inducible_factor-1_alpha	112,144	endothelin-1	53,65	hypoxia-inducible factor-1 alpha	endothelin-1	3091	1906	Gene	Gene	elevates|nmod|START_ENTITY elevates|dobj|expression expression|amod|END_ENTITY	Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible_factor-1_alpha .
18411415	0	hypoxia-inducible_factor-1_alpha	86,118	endothelin-1	32,44	hypoxia-inducible factor-1 alpha	endothelin-1	3091	1906	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Placenta_growth_factor augments endothelin-1 and endothelin-B_receptor expression via hypoxia-inducible_factor-1_alpha .
10942406	0	hypoxia-inducible_factor-1_alpha	46,78	erythropoietin	16,30	hypoxia-inducible factor-1 alpha	erythropoietin	3091	2056	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Epolones induce erythropoietin expression via hypoxia-inducible_factor-1_alpha activation .
17591803	0	hypoxia-inducible_factor-1_alpha	74,106	leptin	34,40	hypoxia-inducible factor-1 alpha	leptin	3091	3952	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible_factor-1_alpha in human colorectal_cancer .
11350893	0	hypoxia-inducible_factor-1_alpha	90,122	vascular_endothelial_growth_factor	12,46	hypoxia-inducible factor-1 alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	Relation|acl|START_ENTITY Relation|nmod|production production|compound|END_ENTITY	Relation of vascular_endothelial_growth_factor production to expression and regulation of hypoxia-inducible_factor-1_alpha and hypoxia-inducible_factor-2_alpha in human bladder_tumors and cell lines .
12368217	0	hypoxia-inducible_factor-1_alpha	45,77	vascular_endothelial_growth_factor	92,126	hypoxia-inducible factor-1 alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Esophageal ulceration triggers expression of hypoxia-inducible_factor-1_alpha and activates vascular_endothelial_growth_factor gene : implications for angiogenesis and ulcer_healing .
15806152	0	hypoxia-inducible_factor-1_alpha	84,116	vascular_endothelial_growth_factor	159,193	hypoxia-inducible factor-1 alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	reduces|xcomp|START_ENTITY reduces|xcomp|leading leading|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible_factor-1_alpha , leading to transcriptional inhibition of vascular_endothelial_growth_factor expression .
26256949	0	hypoxia-inducible_factor-1a	73,100	Akt	101,104	hypoxia-inducible factor-1a	Akt	3091	207	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Hypoxia-mediated cancer stem cells in pseudopalisades with activation of hypoxia-inducible_factor-1a / Akt axis in glioblastoma .
21256111	0	hypoxia-inducible_factor-1a	83,110	Calcineurin_B	0,13	hypoxia-inducible factor-1a	Calcineurin B	3091	5534	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Calcineurin_B subunit interacts with proteasome_subunit_alpha_type_7 and represses hypoxia-inducible_factor-1a activity via the proteasome pathway .
22249478	0	hypoxia-inducible_factor-1a	14,41	HIF-1a	43,49	hypoxia-inducible factor-1a	HIF-1a	3091	3091	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
22249478	0	hypoxia-inducible_factor-1a	14,41	IL-1_b	81,87	hypoxia-inducible factor-1a	IL-1 b	3091	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
20801015	0	hypoxia-inducible_factor-1a	93,120	Interleukin-1b	0,14	hypoxia-inducible factor-1a	Interleukin-1b	3091	3553	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Interleukin-1b regulates the migratory potential of MDAMB231 breast_cancer cells through the hypoxia-inducible_factor-1a .
25120646	0	hypoxia-inducible_factor-1a	132,159	NANOG	106,111	hypoxia-inducible factor-1a	NANOG	3091	79923	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Immunohistochemical expression of four different stem cell markers in prostate_cancer : High expression of NANOG in conjunction with hypoxia-inducible_factor-1a expression is involved in prostate epithelial malignancy .
20715173	0	hypoxia-inducible_factor-1a	61,88	VEGF	23,27	hypoxia-inducible factor-1a	VEGF	3091	7422	Gene	Gene	mechanism|amod|START_ENTITY expression|nmod|mechanism expression|compound|END_ENTITY	Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible_factor-1a protein-dependent mechanism .
23428131	0	hypoxia-inducible_factor-1a	69,96	endothelin-1_and_inducible_nitric_oxide_synthase	98,146	hypoxia-inducible factor-1a	endothelin-1 and inducible nitric oxide synthase	29560(Tax:10116)	24323(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Association between pulmonary_vascular_remodeling and expression of hypoxia-inducible_factor-1a , endothelin-1_and_inducible_nitric_oxide_synthase in pulmonary vessels in neonatal rats with hypoxic_pulmonary_hypertension -RSB- .
22972036	0	hypoxia-inducible_factor-1a	21,48	endothelin-2	67,79	hypoxia-inducible factor-1a	endothelin-2	29560(Tax:10116)	24324(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Regulatory effect of hypoxia-inducible_factor-1a on hCG-stimulated endothelin-2 expression in granulosa cells from the PMSG-treated rat ovary .
21309574	0	hypoxia-inducible_factor-1a	136,163	erythropoietin	57,71	hypoxia-inducible factor-1a	erythropoietin	3091	2056	Gene	Gene	accumulation|nmod|START_ENTITY mediated|nmod|accumulation induce|parataxis|mediated induce|dobj|expression expression|nmod|END_ENTITY	Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells : a signaling mediated via the accumulation of hypoxia-inducible_factor-1a .
25184890	0	hypoxia-inducible_factor-1a	87,114	erythropoietin	68,82	hypoxia-inducible factor-1a	erythropoietin	3091	2056	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	The extract of Ziziphus jujuba fruit -LRB- jujube -RRB- induces expression of erythropoietin via hypoxia-inducible_factor-1a in cultured Hep3B cells .
21890376	0	hypoxia-inducible_factor-1a	12,39	interferon-y	59,71	hypoxia-inducible factor-1a	interferon-y	3091	3458	Gene	Gene	attenuates|amod|START_ENTITY attenuates|amod|END_ENTITY	Blockade of hypoxia-inducible_factor-1a by YC-1 attenuates interferon-y and tumor_necrosis_factor-a-induced intestinal epithelial barrier_dysfunction .
22249478	0	hypoxia-inducible_factor-1a	14,41	interleukin-1b	65,79	hypoxia-inducible factor-1a	interleukin-1b	3091	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|IL-1_b IL-1_b|amod|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
25279184	0	hypoxia-inducible_factor-1a	70,97	membrane-type_2_matrix_metalloproteinase	18,58	hypoxia-inducible factor-1a	membrane-type 2 matrix metalloproteinase	3091	4324	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Overexpression of membrane-type_2_matrix_metalloproteinase induced by hypoxia-inducible_factor-1a in pancreatic_cancer : Implications for tumor progression and prognosis .
25550463	0	hypoxia-inducible_factor-1a	40,67	miR-429	22,29	hypoxia-inducible factor-1a	miR-429	3091	554210	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The hypoxia-inducible miR-429 regulates hypoxia-inducible_factor-1a expression in human endothelial cells through a negative feedback loop .
21256111	0	hypoxia-inducible_factor-1a	83,110	proteasome_subunit_alpha_type_7	37,68	hypoxia-inducible factor-1a	proteasome subunit alpha type 7	3091	5688	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Calcineurin_B subunit interacts with proteasome_subunit_alpha_type_7 and represses hypoxia-inducible_factor-1a activity via the proteasome pathway .
21729202	0	hypoxia-inducible_factor-1a	16,43	vascular_endothelial_growth_factor	77,111	hypoxia-inducible factor-1a	vascular endothelial growth factor	281814(Tax:9913)	7422	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Contribution of hypoxia-inducible_factor-1a to transcriptional regulation of vascular_endothelial_growth_factor in bovine developing luteal cells .
22128293	0	hypoxia-inducible_factor-1a	80,107	vascular_endothelial_growth_factor	41,75	hypoxia-inducible factor-1a	vascular endothelial growth factor	3091	7422	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Hypoxic stress simultaneously stimulates vascular_endothelial_growth_factor via hypoxia-inducible_factor-1a and inhibits stromal cell-derived factor-1 in human endometrial stromal cells .
24890366	0	hypoxia-inducible_factor-1a	41,68	vascular_endothelial_growth_factor	69,103	hypoxia-inducible factor-1a	vascular endothelial growth factor	3091	7422	Gene	Gene	START_ENTITY|dep|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|dep|expression expression|compound|END_ENTITY	Gambogic_acid suppresses hypoxia-induced hypoxia-inducible_factor-1a / vascular_endothelial_growth_factor expression via inhibiting phosphatidylinositol_3-kinase / Akt/mammalian target protein of rapamycin pathway in multiple_myeloma cells .
25543905	0	hypoxia-inducible_factor-1a	75,102	vascular_endothelial_growth_factor	103,137	hypoxia-inducible factor-1a	vascular endothelial growth factor	3091	7422	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Endostar inhibits hypoxia-induced cell proliferation and migration via the hypoxia-inducible_factor-1a / vascular_endothelial_growth_factor pathway in vitro .
19362550	0	hypoxia-inducible_factor-1alpha	97,128	Endothelial_monocyte_activating_polypeptide-II	0,46	hypoxia-inducible factor-1alpha	Endothelial monocyte activating polypeptide-II	3091	9255	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Endothelial_monocyte_activating_polypeptide-II modulates endothelial cell responses by degrading hypoxia-inducible_factor-1alpha through interaction with PSMA7 , a component of the proteasome .
20154724	0	hypoxia-inducible_factor-1alpha	79,110	Epidermal_growth_factor_receptor	0,32	hypoxia-inducible factor-1alpha	Epidermal growth factor receptor	3091	1956	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Epidermal_growth_factor_receptor regulates MET levels and invasiveness through hypoxia-inducible_factor-1alpha in non-small_cell_lung_cancer cells .
15538748	0	hypoxia-inducible_factor-1alpha	18,49	HIF-1alpha	51,61	hypoxia-inducible factor-1alpha	HIF-1alpha	3091	3091	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Identification of hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- polymorphism as a mutation in prostate_cancer that prevents normoxia-induced degradation .
16464515	0	hypoxia-inducible_factor-1alpha	83,114	HIF-1alpha	116,126	hypoxia-inducible factor-1alpha	HIF-1alpha	29560(Tax:10116)	29560(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- protein following focal cerebral_ischemia in rats .
18279708	0	hypoxia-inducible_factor-1alpha	39,70	HIF-1alpha	72,82	hypoxia-inducible factor-1alpha	HIF-1alpha	3091	3091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in the hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- gene in human sporadic_breast_cancer .
20299614	0	hypoxia-inducible_factor-1alpha	57,88	HIF1A	90,95	hypoxia-inducible factor-1alpha	HIF1A	3091	3091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible_factor-1alpha -LRB- HIF1A -RRB- gene in elite endurance athletes .
18003981	0	hypoxia-inducible_factor-1alpha	32,63	IL-18	16,21	hypoxia-inducible factor-1alpha	IL-18	3091	3606	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Hypoxia-induced IL-18 increases hypoxia-inducible_factor-1alpha expression through a Rac1-dependent NF-kappaB pathway .
18400834	0	hypoxia-inducible_factor-1alpha	8,39	IL-8	74,78	hypoxia-inducible factor-1alpha	IL-8	3091	3576	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of hypoxia-inducible_factor-1alpha in hypoxia-induced expressions of IL-8 , MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes .
20216986	0	hypoxia-inducible_factor-1alpha	97,128	PAI-1	75,80	hypoxia-inducible factor-1alpha	PAI-1	3091	5054	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The adaptor protein Ruk/CIN85 activates plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression via hypoxia-inducible_factor-1alpha .
17108010	0	hypoxia-inducible_factor-1alpha	51,82	aquaporin-5	24,35	hypoxia-inducible factor-1alpha	aquaporin-5	29560(Tax:10116)	25241(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY induction|dep|role induction|nmod|END_ENTITY	Hypertonic induction of aquaporin-5 : novel role of hypoxia-inducible_factor-1alpha .
16099863	0	hypoxia-inducible_factor-1alpha	64,95	c-met	17,22	hypoxia-inducible factor-1alpha	c-met	3091	4233	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Up-regulation of c-met protooncogene product expression through hypoxia-inducible_factor-1alpha is involved in trophoblast invasion under low-oxygen tension .
17931419	0	hypoxia-inducible_factor-1alpha	172,203	epidermal_growth_factor_receptor	75,107	hypoxia-inducible factor-1alpha	epidermal growth factor receptor	3091	1956	Gene	Gene	downregulation|nmod|START_ENTITY linked|nmod|downregulation linked|nsubjpass|Responses Responses|nmod|cells cells|nmod|END_ENTITY	Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal_growth_factor_receptor -LRB- EGFR -RRB- to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible_factor-1alpha .
20188165	0	hypoxia-inducible_factor-1alpha	96,127	manganese-superoxide_dismutase	53,83	hypoxia-inducible factor-1alpha	manganese-superoxide dismutase	3091	6648	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Reactive oxygen species produced by the knockdown of manganese-superoxide_dismutase up-regulate hypoxia-inducible_factor-1alpha expression in oral_squamous_cell_carcinoma cells .
20216986	0	hypoxia-inducible_factor-1alpha	97,128	plasminogen_activator_inhibitor-1	40,73	hypoxia-inducible factor-1alpha	plasminogen activator inhibitor-1	3091	5054	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The adaptor protein Ruk/CIN85 activates plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression via hypoxia-inducible_factor-1alpha .
16618748	0	hypoxia-inducible_factor-1alpha	111,142	vascular_endothelial_growth_factor	61,95	hypoxia-inducible factor-1alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
11888900	0	hypoxia-inducible_factor-2_alpha	12,44	HIF-2_alpha	46,57	hypoxia-inducible factor-2 alpha	HIF-2 alpha	2034	2034	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Relation of hypoxia-inducible_factor-2_alpha -LRB- HIF-2_alpha -RRB- expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast_cancer .
24347567	0	hypoxia-inducible_factor-2a	37,64	NAMPT	0,5	hypoxia-inducible factor-2a	NAMPT	13819(Tax:10090)	59027(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	NAMPT -LRB- visfatin -RRB- , a direct target of hypoxia-inducible_factor-2a , is an essential catabolic regulator of osteoarthritis .
14767275	0	hypoxia-inducible_factor-2alpha	69,100	endothelial_Per-Arnt-sim_domain_protein_1	27,68	hypoxia-inducible factor-2alpha	endothelial Per-Arnt-sim domain protein 1	2034	2034	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of endothelial_Per-Arnt-sim_domain_protein_1 / hypoxia-inducible_factor-2alpha expression in a subset of tumor associated macrophages in invasive_bladder_cancer .
15901372	1	hypoxia-inducible_factor_1	33,59	HIF-1	61,66	hypoxia-inducible factor 1	HIF-1	3091	3091	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- by nitric_oxide in oral_squamous_cell_carcinoma .
24347168	0	hypoxia-inducible_factor_1	87,113	HIF-1	115,120	hypoxia-inducible factor 1	HIF-1	3091	3091	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Endoplasmic reticulum -LRB- ER -RRB- stress and hypoxia response pathways interact to potentiate hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- transcriptional activity on targets like vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
19996311	0	hypoxia-inducible_factor_1	41,67	Insulin	0,7	hypoxia-inducible factor 1	Insulin	3091	3630	Gene	Gene	activation|amod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Insulin induces REDD1 expression through hypoxia-inducible_factor_1 activation in adipocytes .
19720740	0	hypoxia-inducible_factor_1	4,30	NOR-1	31,36	hypoxia-inducible factor 1	NOR-1	3091	8013	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|axis axis|compound|END_ENTITY	The hypoxia-inducible_factor_1 / NOR-1 axis regulates the survival response of endothelial cells to hypoxia .
18268343	0	hypoxia-inducible_factor_1	30,56	PTEN	0,4	hypoxia-inducible factor 1	PTEN	3091	5728	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PTEN regulates p300-dependent hypoxia-inducible_factor_1 transcriptional activity through Forkhead transcription factor 3a -LRB- FOXO3a -RRB- .
19996311	0	hypoxia-inducible_factor_1	41,67	REDD1	16,21	hypoxia-inducible factor 1	REDD1	3091	54541	Gene	Gene	activation|amod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|compound|END_ENTITY	Insulin induces REDD1 expression through hypoxia-inducible_factor_1 activation in adipocytes .
12727858	0	hypoxia-inducible_factor_1	116,142	Vascular_endothelial_growth_factor	0,34	hypoxia-inducible factor 1	Vascular endothelial growth factor	3091	7422	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor gene expression in colon_cancer cells exposed to prostaglandin_E2 is mediated by hypoxia-inducible_factor_1 .
18979225	0	hypoxia-inducible_factor_1	50,76	hepatocyte_growth_factor	17,41	hypoxia-inducible factor 1	hepatocyte growth factor	3091	3082	Gene	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|mRNA mRNA|compound|END_ENTITY	Stabilization of hepatocyte_growth_factor mRNA by hypoxia-inducible_factor_1 .
11866451	0	hypoxia-inducible_factor_1	60,86	vascular_endothelial_growth_factor	17,51	hypoxia-inducible factor 1	vascular endothelial growth factor	3091	7422	Gene	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|mRNA mRNA|compound|END_ENTITY	Stabilization of vascular_endothelial_growth_factor mRNA by hypoxia-inducible_factor_1 .
24347168	0	hypoxia-inducible_factor_1	87,113	vascular_endothelial_growth_factor	163,197	hypoxia-inducible factor 1	vascular endothelial growth factor	3091	7422	Gene	Gene	activity|amod|START_ENTITY activity|nmod|targets targets|nmod|END_ENTITY	Endoplasmic reticulum -LRB- ER -RRB- stress and hypoxia response pathways interact to potentiate hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- transcriptional activity on targets like vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
8756616	0	hypoxia-inducible_factor_1	71,97	vascular_endothelial_growth_factor	14,48	hypoxia-inducible factor 1	vascular endothelial growth factor	3091	7422	Gene	Gene	transcription|advcl|START_ENTITY transcription|nsubj|Activation Activation|nmod|gene gene|compound|END_ENTITY	Activation of vascular_endothelial_growth_factor gene transcription by hypoxia-inducible_factor_1 .
25017895	0	hypoxia-inducible_factor_1-beta	29,60	ARNT	62,66	hypoxia-inducible factor 1-beta	ARNT	11863(Tax:10090)	11863(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Differential distribution of hypoxia-inducible_factor_1-beta -LRB- ARNT or ARNT2 -RRB- in mouse substantia nigra and ventral tegmental area .
24232601	0	hypoxia-inducible_factor_1A	49,76	HIF1A	78,83	hypoxia-inducible factor 1A	HIF1A	3091	3091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between the polymorphisms of hypoxia-inducible_factor_1A -LRB- HIF1A -RRB- gene and SLE susceptibility in a Chinese population .
24127318	0	hypoxia-inducible_factor_1_alpha	18,50	FoxP3	59,64	hypoxia-inducible factor 1 alpha	FoxP3	3091	50943	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Overexpression of hypoxia-inducible_factor_1_alpha impacts FoxP3 levels in mycosis fungoides -- cutaneous_T-cell_lymphoma : clinical implications .
14672622	0	hypoxia-inducible_factor_1_alpha	68,100	Hexokinase_II	0,13	hypoxia-inducible factor 1 alpha	Hexokinase II	3091	3099	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|compound|END_ENTITY	Hexokinase_II and VEGF expression in liver_tumors : correlation with hypoxia-inducible_factor_1_alpha and its significance .
16157596	0	hypoxia-inducible_factor_1alpha	15,46	HIF-1alpha	48,58	hypoxia-inducible factor 1alpha	HIF-1alpha	3091	3091	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Suppression of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- transcriptional activity by the HIF prolyl hydroxylase EGLN1 .
15337760	0	hypoxia-inducible_factor_1alpha	77,108	Vascular_endothelial_growth_factor	0,34	hypoxia-inducible factor 1alpha	Vascular endothelial growth factor	3091	7422	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|activation activation|amod|END_ENTITY	Vascular_endothelial_growth_factor transcriptional activation is mediated by hypoxia-inducible_factor_1alpha , HDM2 , and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling .
15525582	0	hypoxia-inducible_factor_1alpha	54,85	glucose_transporter_1	13,34	hypoxia-inducible factor 1alpha	glucose transporter 1	3091	6513	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of glucose_transporter_1 expression through hypoxia-inducible_factor_1alpha under hypoxic conditions in trophoblast-derived cells .
12242281	0	hypoxia-inducible_factor_1alpha	14,45	mammalian_target_of_rapamycin	77,106	hypoxia-inducible factor 1alpha	mammalian target of rapamycin	3091	2475	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor_1alpha expression and function by the mammalian_target_of_rapamycin .
10987301	0	hypoxia-inducible_factor_1alpha	213,244	vascular_endothelial_growth_factor	85,119	hypoxia-inducible factor 1alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	acting|advcl|START_ENTITY kinase|acl|acting END_ENTITY|nmod|kinase	The Kaposi 's _ sarcoma-associated_herpes_virus G protein-coupled receptor up-regulates vascular_endothelial_growth_factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible_factor_1alpha .
11359907	0	hypoxia-inducible_factor_1alpha	43,74	vascular_endothelial_growth_factor	134,168	hypoxia-inducible factor 1alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	synthesis|amod|START_ENTITY synthesis|dep|mechanism mechanism|nmod|expression expression|compound|END_ENTITY	HER2 -LRB- neu -RRB- signaling increases the rate of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- synthesis : novel mechanism for HIF-1-mediated vascular_endothelial_growth_factor expression .
14678768	0	hypoxia-inducible_factor_1alpha	14,45	vascular_endothelial_growth_factor	63,97	hypoxia-inducible factor 1alpha	vascular endothelial growth factor	29560(Tax:10116)	83785(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor_1alpha and induction of vascular_endothelial_growth_factor in a rat neonatal_stroke model .
18305118	0	hypoxia-inducible_factor_1alpha	13,44	vascular_endothelial_growth_factor	64,98	hypoxia-inducible factor 1alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of hypoxia-inducible_factor_1alpha gene expression by vascular_endothelial_growth_factor .
19498162	0	hypoxia-inducible_factor_2alpha	14,45	sirtuin_1	93,102	hypoxia-inducible factor 2alpha	sirtuin 1	13819(Tax:10090)	93759(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor_2alpha signaling by the stress-responsive deacetylase sirtuin_1 .
19147576	0	hypoxia-inducible_factor_prolyl_hydroxylase_2	33,78	Melanoma_antigen-11	0,19	hypoxia-inducible factor prolyl hydroxylase 2	Melanoma antigen-11	54583	4110	Gene	Gene	response|amod|START_ENTITY inhibits|dobj|response inhibits|nsubj|END_ENTITY	Melanoma_antigen-11 inhibits the hypoxia-inducible_factor_prolyl_hydroxylase_2 and activates hypoxic response .
18945681	0	hypoxia-inducible_factors_1_alpha_and_2_alpha	27,72	mTORC1	76,82	hypoxia-inducible factors 1 alpha and 2 alpha	mTORC1	3091;2034	382056(Tax:10090)	Gene	Gene	dependence|nmod|START_ENTITY dependence|nmod|END_ENTITY	Differential dependence of hypoxia-inducible_factors_1_alpha_and_2_alpha on mTORC1 and mTORC2 .
11532856	0	hypoxia_inducible_factor-1	47,73	HIF-1	75,80	hypoxia inducible factor-1	HIF-1	3091	3091	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Hepatocyte_growth_factor signalling stimulates hypoxia_inducible_factor-1 -LRB- HIF-1 -RRB- activity in HepG2 hepatoma cells .
18635960	0	hypoxia_inducible_factor-1	20,46	TWIST	0,5	hypoxia inducible factor-1	TWIST	3091	7291	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	TWIST activation by hypoxia_inducible_factor-1 -LRB- HIF-1 -RRB- : implications in metastasis and development .
17922867	0	hypoxia_inducible_factor-1_alpha	82,114	Glucose_transporter-1	0,21	hypoxia inducible factor-1 alpha	Glucose transporter-1	3091	6513	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Glucose_transporter-1 expression in renal_cell_carcinoma and its correlation with hypoxia_inducible_factor-1_alpha .
18591213	0	hypoxia_inducible_factor-1_alpha	17,49	HCG	0,3	hypoxia inducible factor-1 alpha	HCG	3091	1081	Gene	Gene	up-regulates|amod|START_ENTITY up-regulates|compound|END_ENTITY	HCG up-regulates hypoxia_inducible_factor-1_alpha in luteinized granulosa cells : implications for the hormonal regulation of vascular_endothelial_growth_factor_A in the human corpus luteum .
18476562	0	hypoxia_inducible_factor-1_alpha	11,43	vascular_endothelial_growth_factor	47,81	hypoxia inducible factor-1 alpha	vascular endothelial growth factor	3091	7422	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of hypoxia_inducible_factor-1_alpha on vascular_endothelial_growth_factor expression in human tongue squamous_carcinoma cells -LRB- Tca8113 -RRB- under hypoxia -RSB- .
26113285	0	hypoxia_inducible_factor-1a	14,41	HIF-1a	43,49	hypoxia inducible factor-1a	HIF-1a	3091	3091	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Impact of the hypoxia_inducible_factor-1a -LRB- HIF-1a -RRB- pro582ser polymorphism and its gene expression on diabetic_foot_ulcers .
26113285	0	hypoxia_inducible_factor-1a	14,41	HIF-1a	43,49	hypoxia inducible factor-1a	HIF-1a	3091	3091	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Impact of the hypoxia_inducible_factor-1a -LRB- HIF-1a -RRB- pro582ser polymorphism and its gene expression on diabetic_foot_ulcers .
21401309	0	hypoxia_inducible_factor-1a	12,39	MMP-2	57,62	hypoxia inducible factor-1a	MMP-2	3091	4313	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	The role of hypoxia_inducible_factor-1a in the increased MMP-2 and MMP-9 production by human monocytes exposed to nickel nanoparticles .
23924606	0	hypoxia_inducible_factor-1a	8,35	OATP1B3	132,139	hypoxia inducible factor-1a	OATP1B3	3091	28234	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of hypoxia_inducible_factor-1a in the regulation of the cancer-specific variant of organic_anion_transporting_polypeptide_1B3 -LRB- OATP1B3 -RRB- , in colon_and_pancreatic_cancer .
17409425	0	hypoxia_inducible_factor-1alpha	28,59	BRAF	13,17	hypoxia inducible factor-1alpha	BRAF	3091	673	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Mutant V600E BRAF increases hypoxia_inducible_factor-1alpha expression in melanoma .
15350301	0	hypoxia_inducible_factor-1alpha	21,52	HIF1A	59,64	hypoxia inducible factor-1alpha	HIF1A	3091	3091	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the hypoxia_inducible_factor-1alpha gene -LRB- HIF1A -RRB- are associated with the renal_cell_carcinoma phenotype .
19080496	0	hypoxia_inducible_factor-1alpha	84,115	leptin	28,34	hypoxia inducible factor-1alpha	leptin	3091	3952	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	-LSB- Mechanism of regulation of leptin expression in human lung_adenocarcinoma cells by hypoxia_inducible_factor-1alpha : a preliminary study -RSB- .
15713437	0	hypoxia_inducible_factor-1alpha	15,46	vascular_endothelial_growth_factor-C	77,113	hypoxia inducible factor-1alpha	vascular endothelial growth factor-C	3091	7424	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of hypoxia_inducible_factor-1alpha with lymphatic metastasis via vascular_endothelial_growth_factor-C in human esophageal_cancer .
16394508	0	hypoxia_inducible_factor-2alpha	34,65	HIF-2alpha	67,77	hypoxia inducible factor-2alpha	HIF-2alpha	13819(Tax:10090)	13819(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the hypoxia_inducible_factor-2alpha -LRB- HIF-2alpha -RRB- gene during adipose differentiation in 3T3-L1 cells .
15452150	0	hypoxia_inducible_factor_1	12,38	HIF-1	40,45	hypoxia inducible factor 1	HIF-1	3091	3091	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of hypoxia_inducible_factor_1 -LRB- HIF-1 -RRB- in hypoxia induced apoptosis .
23786956	0	hypoxia_inducible_factor_1	99,125	mammalian_target_of_rapamycin	69,98	hypoxia inducible factor 1	mammalian target of rapamycin	3091	2475	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Chronic intermittent_hypoxia increases b cell mass and activates the mammalian_target_of_rapamycin / hypoxia_inducible_factor_1 / vascular_endothelial_growth_factor_A pathway in mice pancreatic islet .
15315159	0	hypoxia_inducible_factor_1-alpha	18,50	P53	91,94	hypoxia inducible factor 1-alpha	P53	3091	7157	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of hypoxia_inducible_factor_1-alpha in lung_cancer and its correlation with P53 and VEGF .
22971798	0	hypoxia_inducible_factor_1a	86,113	glucose_transporter_protein-1	14,43	hypoxia inducible factor 1a	glucose transporter protein-1	3091	6513	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of glucose_transporter_protein-1 and vascular_endothelial_growth_factor by hypoxia_inducible_factor_1a under hypoxic conditions in Hep-2 human cells .
19149949	0	hypoxia_inducible_factor_1alpha	22,53	HIF-1alpha	55,65	hypoxia inducible factor 1alpha	HIF-1alpha	3091	3091	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	-LSB- Effect of hypoxia on hypoxia_inducible_factor_1alpha -LRB- HIF-1alpha -RRB- activation in intestinal epithelial cells -RSB- .
17292638	0	hypoxia_inducible_factor_1alpha	21,52	HIF1alpha	54,63	hypoxia inducible factor 1alpha	HIF1alpha	3091	3091	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Association study of hypoxia_inducible_factor_1alpha -LRB- HIF1alpha -RRB- with osteonecrosis of femoral head in a Korean population .
17324924	0	hypoxia_inducible_factor_2_alpha	53,85	Int6	27,31	hypoxia inducible factor 2 alpha	Int6	2034	3646	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Mammalian tumor suppressor Int6 specifically targets hypoxia_inducible_factor_2_alpha for degradation by hypoxia - and pVHL-independent regulation .
24330727	0	hypoxia_inducible_factor_2a	26,53	Interleukin-1b	0,14	hypoxia inducible factor 2a	Interleukin-1b	2034	3553	Gene	Gene	sequesters|dobj|START_ENTITY sequesters|nsubj|END_ENTITY	Interleukin-1b sequesters hypoxia_inducible_factor_2a to the primary cilium .
26787707	0	iASPP	95,100	MicroRNA-140	0,12	iASPP	MicroRNA-140	10848	406932	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-140 regulates cell growth and invasion in pancreatic_duct_adenocarcinoma by targeting iASPP .
17391696	0	iASPP	37,42	p53	68,71	iASPP	p53	10848	7157	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel isoform of iASPP and its interaction with p53 .
17906639	0	iASPP	101,106	p53	39,42	iASPP	p53	10848	7157	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|compound|END_ENTITY	The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP .
22552744	0	iASPP	148,153	p53	141,144	iASPP	p53	10848	7157	Gene	Gene	apoptosis|nmod|START_ENTITY apoptosis|nmod|END_ENTITY	Abnormal expression pattern of the ASPP family of proteins in human non-small_cell_lung_cancer and regulatory functions on apoptosis through p53 by iASPP .
25752455	0	iNOS	50,54	ATF3	15,19	iNOS	ATF3	18126(Tax:10090)	11910(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Involvement|nmod|expression Involvement|nmod|END_ENTITY	Involvement of ATF3 in the negative regulation of iNOS expression and NO production in activated macrophages .
15001568	0	iNOS	82,86	Angiotensin_II	0,14	iNOS	Angiotensin II	24599(Tax:10116)	24179(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Angiotensin_II differentially regulates interleukin-1-beta-inducible_NO_synthase -LRB- iNOS -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression : role of p38 MAPK .
11834703	0	iNOS	20,24	C/EBP-beta	0,10	iNOS	C/EBP-beta	24599(Tax:10116)	24253(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	C/EBP-beta mediates iNOS induction by hypoxia in rat pulmonary microvascular smooth muscle cells .
23416151	0	iNOS	29,33	CD14	11,15	iNOS	CD14	18126(Tax:10090)	12475(Tax:10090)	Gene	Gene	activated|nmod|START_ENTITY END_ENTITY|acl|activated	Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral_ischemia .
20888597	0	iNOS	106,110	CD25	36,40	iNOS	CD25	18126(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Effects Effects|nmod|saline saline|nmod|Foxp3 Foxp3|compound|END_ENTITY	Effects of hypertonic saline on CD4 + CD25 + Foxp3 + regulatory T cells after hemorrhagic_shock in relation to iNOS and cytokines .
17879278	0	iNOS	72,76	CD4	128,131	iNOS	CD4	18126(Tax:10090)	12504(Tax:10090)	Gene	Gene	synthase|appos|START_ENTITY synthase|nmod|cells cells|nmod|transfer transfer|nmod|END_ENTITY	Early bacterial dependent induction of inducible nitric_oxide synthase -LRB- iNOS -RRB- in epithelial cells upon transfer of CD45RB -LRB- high -RRB- CD4 -LRB- + -RRB- T cells in a model for experimental colitis .
20888597	0	iNOS	106,110	CD4	32,35	iNOS	CD4	18126(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Effects Effects|nmod|saline saline|nmod|Foxp3 Foxp3|compound|END_ENTITY	Effects of hypertonic saline on CD4 + CD25 + Foxp3 + regulatory T cells after hemorrhagic_shock in relation to iNOS and cytokines .
25278453	0	iNOS	0,4	CD4	19,22	iNOS	CD4	18126(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	iNOS expression in CD4 + T cells limits T-reg induction by repressing TGFb-1 : combined iNOS inhibition and T-reg depletion unmask endogenous anti-tumor immunity .
25278453	0	iNOS	86,90	CD4	19,22	iNOS	CD4	18126(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY endogenous|nsubj|inhibition limits|parataxis|endogenous limits|nsubj|expression expression|nmod|cells cells|compound|END_ENTITY	iNOS expression in CD4 + T cells limits T-reg induction by repressing TGFb-1 : combined iNOS inhibition and T-reg depletion unmask endogenous anti-tumor immunity .
19457095	0	iNOS	20,24	CGRP	0,4	iNOS	CGRP	24599(Tax:10116)	24241(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	CGRP stimulation of iNOS and NO release from trigeminal ganglion glial cells involves mitogen-activated protein kinase pathways .
14719508	0	iNOS	88,92	COX-2	78,83	iNOS	COX-2	4843	5743	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Expression of beta-catenin , COX-2 and iNOS in colorectal_cancer : relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia .
16572897	0	iNOS	12,16	COX-2	5,10	iNOS	COX-2	4843	4513	Gene	Gene	START_ENTITY|nsubj|P53 P53|appos|END_ENTITY	P53 , COX-2 , iNOS protein expression changes and their relationship with anti-oxidant enzymes in surgically and multi-modality treated esophageal_carcinoma patients .
18057724	0	iNOS	26,30	COX-2	32,37	iNOS	COX-2	18126(Tax:10090)	19225(Tax:10090)	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Inhibition of LPS-induced iNOS , COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells .
18579232	0	iNOS	41,45	COX-2	35,40	iNOS	COX-2	4843	4513	Gene	Gene	antibodies|dep|START_ENTITY antibodies|acl:relcl|induce induce|dobj|END_ENTITY	Chagasic antibodies induce cardiac COX-2 / iNOS mRNA expression with PGE2/NO production .
18634870	0	iNOS	73,77	COX-2	83,88	iNOS	COX-2	18126(Tax:10090)	19225(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	HO-1 and JAK-2 / STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline_alkaloid , CKD712 , in cells activated with lipopolysacchride .
18821215	0	iNOS	36,40	COX-2	42,47	iNOS	COX-2	4843	5743	Gene	Gene	START_ENTITY|appos|production production|amod|END_ENTITY	Retinoid_acid inhibits IL-1-induced iNOS , COX-2 and chemokine production in human chondrocytes .
19222121	0	iNOS	26,30	COX-2	32,37	iNOS	COX-2	18126(Tax:10090)	17709(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|expression expression|amod|END_ENTITY	Inhibition of LPS-induced iNOS , COX-2 and inflammatory mediator expression by paeonol through the MAPKs inactivation in RAW 264.7 cells .
20845789	0	iNOS	54,58	COX-2	60,65	iNOS	COX-2	24599(Tax:10116)	26198(Tax:10116)	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|nmod:poss|END_ENTITY	-LSB- Effects of Valeriana amurensis on the expressions of iNOS , COX-2 and IkappaCB-alpha in Alzheimer 's _ disease model rat 's brain -RSB- .
21656334	0	iNOS	75,79	COX-2	81,86	iNOS	COX-2	18126(Tax:10090)	19225(Tax:10090)	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Phellinus baumii ethyl_acetate extract inhibits lipopolysaccharide-induced iNOS , COX-2 , and proinflammatory cytokine expression in RAW264 .7 cells .
22197135	0	iNOS	94,98	COX-2	100,105	iNOS	COX-2	4843	4513	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|dep|END_ENTITY	A concise synthesis of viscolin , and its anti-inflammatory effects through the suppression of iNOS , COX-2 , ERK phosphorylation and proinflammatory cytokines expressions .
22331023	0	iNOS	49,53	COX-2	37,42	iNOS	COX-2	4843	5743	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|genes genes|acl|encoding encoding|nmod|MPO MPO|compound|END_ENTITY	The expression of genes encoding for COX-2 , MPO , iNOS , and sPLA2-IIA in patients with recurrent depressive_disorder .
22683859	0	iNOS	0,4	COX-2	30,35	iNOS	COX-2	4843	4513	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|pathway pathway|compound|END_ENTITY	iNOS signaling interacts with COX-2 pathway in colonic fibroblasts .
23886206	0	iNOS	90,94	COX-2	96,101	iNOS	COX-2	18126(Tax:10090)	17709(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24556222	0	iNOS	46,50	COX-2	39,44	iNOS	COX-2	18126(Tax:10090)	17709(Tax:10090)	Gene	Gene	cytokines|dep|START_ENTITY cytokines|compound|END_ENTITY	Tinospora cordifolia extract modulates COX-2 , iNOS , ICAM-1 , pro-inflammatory cytokines and redox status in murine model of asthma .
25000190	0	iNOS	72,76	COX-2	66,71	iNOS	COX-2	4843	4513	Gene	Gene	signaling|dep|START_ENTITY signaling|nsubj|/ /|compound|END_ENTITY	Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2 / iNOS and NF-kB/p300 signaling pathways .
27091651	0	iNOS	111,115	COX-2	24,29	iNOS	COX-2	18126(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY reduction|nmod|expression wound|nmod|reduction improves|ccomp|wound improves|nsubj|inhibition inhibition|nmod|END_ENTITY	Selective inhibition of COX-2 improves cutaneous wound healing of pressure ulcers in mice through reduction of iNOS expression .
21620800	0	iNOS	44,48	CPEB1	0,5	iNOS	CPEB1	24599(Tax:10116)	293056(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes .
22197135	0	iNOS	94,98	ERK	107,110	iNOS	ERK	4843	5594	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|dep|END_ENTITY	A concise synthesis of viscolin , and its anti-inflammatory effects through the suppression of iNOS , COX-2 , ERK phosphorylation and proinflammatory cytokines expressions .
16436473	0	iNOS	57,61	ERK1/2	33,39	iNOS	ERK1/2	24599(Tax:10116)	50689;116590	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells .
12839867	0	iNOS	40,44	Endothelin-1	0,12	iNOS	Endothelin-1	4843	1906	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits TNF_alpha-induced iNOS expression in 3T3-F442A adipocytes .
17940874	0	iNOS	11,15	GFAP	17,21	iNOS	GFAP	24599(Tax:10116)	24387(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	Changes in iNOS , GFAP and NR1 expression in various brain regions and elevation of sphingosine-1-phosphate in serum after immobilized stress .
23886206	0	iNOS	90,94	GM-CSF	129,135	iNOS	GM-CSF	18126(Tax:10090)	12981(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|acl|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
26361746	0	iNOS	40,44	Glutathione_S-transferase_P1	0,28	iNOS	Glutathione S-transferase P1	18126(Tax:10090)	14870(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Glutathione_S-transferase_P1 suppresses iNOS protein stability in RAW264 .7 macrophage-like cells after LPS stimulation .
16479620	0	iNOS	66,70	HNF4alpha	8,17	iNOS	HNF4alpha	4843	3172	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of HNF4alpha in the superinduction of the IL-1beta-activated iNOS gene by oxidative stress .
15050899	0	iNOS	79,83	HO-1	73,77	iNOS	HO-1	24599(Tax:10116)	24451(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Activation of the transcription factor HIF-1 and its target genes , VEGF , HO-1 , iNOS , during fracture repair .
15498032	0	iNOS	72,76	HO-1	22,26	iNOS	HO-1	18126(Tax:10090)	15368(Tax:10090)	Gene	Gene	reducing|dobj|START_ENTITY lupus_nephritis|advcl|reducing lupus_nephritis|nsubj|induction induction|nmod|suppresses suppresses|compound|END_ENTITY	Chemical induction of HO-1 suppresses lupus_nephritis by reducing local iNOS expression and synthesis of anti-dsDNA antibody .
15740980	0	iNOS	118,122	HO-1	19,23	iNOS	HO-1	51477	3162	Gene	Gene	START_ENTITY|nsubj|Super-induction Super-induction|nmod|END_ENTITY	Super-induction of HO-1 in macrophages stimulated with lipopolysaccharide by prior depletion of glutathione decreases iNOS expression and NO production .
18634870	0	iNOS	73,77	HO-1	0,4	iNOS	HO-1	18126(Tax:10090)	15368(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY involved|nmod|inhibition involved|nsubjpass|signals signals|amod|END_ENTITY	HO-1 and JAK-2 / STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline_alkaloid , CKD712 , in cells activated with lipopolysacchride .
11171562	0	iNOS	29,33	IFN-gamma	0,9	iNOS	IFN-gamma	18126(Tax:10090)	15978(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	IFN-gamma + LPS induction of iNOS is modulated by ERK , JNK/SAPK , and p38 -LRB- mapk -RRB- in a mouse macrophage cell line .
11704648	0	iNOS	111,115	IFN-gamma	170,179	iNOS	IFN-gamma	18126(Tax:10090)	15978(Tax:10090)	Gene	Gene	inducible_nitric_oxide_synthase|appos|START_ENTITY inducible_nitric_oxide_synthase|dep|expression expression|acl|induced induced|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	N - -LSB- 3,4-dimethoxycinnamoyl -RSB- - anthranilic_acid -LRB- tranilast -RRB- suppresses microglial inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression and activity induced by interferon-gamma -LRB- IFN-gamma -RRB- .
15591835	0	iNOS	11,15	IFN-gamma	29,38	iNOS	IFN-gamma	18126(Tax:10090)	15978(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY Effects|nmod|inhibitor Effects|nmod|production production|amod|END_ENTITY	Effects of iNOS inhibitor on IFN-gamma production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma_gondii .
15715934	0	iNOS	32,36	IFN-gamma	93,102	iNOS	IFN-gamma	4843	3458	Gene	Gene	START_ENTITY|nmod|cells cells|acl|stimulated stimulated|nmod|END_ENTITY	Diethyldithiocarbamate inhibits iNOS expression in human lens epithelial cells stimulated by IFN-gamma and LPS .
9058189	0	iNOS	218,222	IFN-gamma	180,189	iNOS	IFN-gamma	18126(Tax:10090)	15978(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY heterogeneity|nmod|activity Differences|dep|heterogeneity Differences|nmod|activity activity|nmod|line line|acl|treated treated|nmod|lipopolysaccharide lipopolysaccharide|nmod|presence presence|nmod|interferon-gamma interferon-gamma|appos|END_ENTITY	Differences in nitric_oxide_synthase activity in a macrophage-like cell line , RAW264 .7 cells , treated with lipopolysaccharide -LRB- LPS -RRB- in the presence or absence of interferon-gamma -LRB- IFN-gamma -RRB- : possible heterogeneity of iNOS activity .
9641464	0	iNOS	45,49	IFN-gamma	22,31	iNOS	IFN-gamma	4843	3458	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric_oxide inhibition of adenylate cyclase .
24673524	0	iNOS	14,18	IGF-1	0,5	iNOS	IGF-1	4843	3479	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IGF-1 induces iNOS expression via the p38 MAPK signal pathway in the anti-apoptotic process in pulmonary artery smooth muscle cells during PAH .
16283110	0	iNOS	31,35	IL-1	17,21	iNOS	IL-1	4843	3553	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	TGFbeta inhibits IL-1 - induced iNOS expression and NO production in immortalized chondrocytes .
10898750	0	iNOS	50,54	IL-10	44,49	iNOS	IL-10	18126(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|chronic_colitis chronic_colitis|nmod|/ /|compound|END_ENTITY	Spontaneously developing chronic_colitis in IL-10 / iNOS double-deficient mice .
11406467	0	iNOS	64,68	IL-10	39,44	iNOS	IL-10	18126(Tax:10090)	16153(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|actions actions|nmod|END_ENTITY	Cardioprotective actions of endogenous IL-10 are independent of iNOS .
18565249	0	iNOS	10,14	IL-10	55,60	iNOS	IL-10	51477	3586	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage .
18991287	0	iNOS	31,35	IL-10	65,70	iNOS	IL-10	18126(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|repression repression|nmod|formation formation|compound|END_ENTITY	Nramp1-functionality increases iNOS expression via repression of IL-10 formation .
9555975	0	iNOS	21,25	IL-10	12,17	iNOS	IL-10	282876(Tax:9913)	281246(Tax:9913)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of IL-10 in iNOS and cytokine mRNA expression during in vitro differentiation of bovine mononuclear phagocytes .
12237122	0	iNOS	19,23	IL-15	0,5	iNOS	IL-15	4843	3600	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	IL-15 up-regulates iNOS expression and NO production by gingival epithelial cells .
16652188	0	iNOS	43,47	IL-18	10,15	iNOS	IL-18	51477	3606	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of IL-18 on leukocyte expression of iNOS and phospho-IkB in patients with squamous_cell_carcinoma_of_the_oral_cavity .
21035557	0	iNOS	65,69	IL-1b	26,31	iNOS	IL-1b	4843	3553	Gene	Gene	synthase|appos|START_ENTITY synthase|amod|inducible inducible|amod|END_ENTITY	Selenomethionine inhibits IL-1b inducible nitric_oxide synthase -LRB- iNOS -RRB- and cyclooxygenase_2 -LRB- COX2 -RRB- expression in primary human chondrocytes .
22342441	0	iNOS	210,214	IL-1b	184,189	iNOS	IL-1b	18126(Tax:10090)	16176(Tax:10090)	Gene	Gene	cytokines|dep|START_ENTITY cytokines|appos|TNF-a TNF-a|dep|END_ENTITY	Inhibitory effects of bioactive leads isolated from Pseudomonas_aeruginosa PS3 and Pseudomonas_fluorescens PS7 on MAP kinases and down regulation of pro inflammatory cytokines -LRB- TNF-a , IL-1b -RRB- and mediators -LRB- NO , iNOS and COX -RRB- .
23886206	0	iNOS	90,94	IL-1b	103,108	iNOS	IL-1b	18126(Tax:10090)	16176(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
24014650	0	iNOS	14,18	IL-1b	41,46	iNOS	IFN-y	4843	3458	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Regulation of iNOS gene transcription by IL-1b and IFN-y requires a coactivator exchange mechanism .
25160751	0	iNOS	52,56	IL-1b	37,42	iNOS	IL-1b	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mediated|dobj|expression mediated|nsubj|END_ENTITY	Glycogen synthase kinase 3 regulates IL-1b mediated iNOS expression in hepatocytes by down-regulating c-Jun .
11006448	0	iNOS	47,51	IL-1beta	87,95	iNOS	IL-1beta	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	synthase|dobj|START_ENTITY synthase|nmod|END_ENTITY	Expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in middle_ear_epithelial_cells by IL-1beta and TNF-alpha .
11989973	0	iNOS	104,108	IL-1beta	26,34	iNOS	IL-1beta	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|effect effect|nmod|END_ENTITY	The stimulatory effect of IL-1beta on the insulin secretion of rat pancreatic islet is not related with iNOS pathway .
12062366	0	iNOS	13,17	IL-1beta	51,59	iNOS	IL-1beta	4843	3553	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation : an in vitro and in vivo study .
16436473	0	iNOS	57,61	IL-1beta	65,73	iNOS	IL-1beta	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nmod|END_ENTITY	PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells .
16912414	0	iNOS	49,53	IL-1beta	32,40	iNOS	IL-1beta	51477	3553	Gene	Gene	activity|amod|START_ENTITY induced|dobj|activity END_ENTITY|acl|induced	Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs .
19291698	0	iNOS	52,56	IL-32	32,37	iNOS	IL-32	51477	9235	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus_infection .
17189827	0	iNOS	90,94	IL-6	14,18	iNOS	IL-6	18126(Tax:10090)	16193(Tax:10090)	Gene	Gene	synthase|appos|START_ENTITY expression|nmod|synthase signaling|nmod|expression role|parataxis|signaling role|nmod|END_ENTITY	Novel role of IL-6 / SIL-6R signaling in the expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in murine B16 , metastatic melanoma clone F10 .9 , cells .
23886206	0	iNOS	90,94	IL-6	110,114	iNOS	IL-6	18126(Tax:10090)	16193(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|appos|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
10188914	0	iNOS	33,37	Inducible_nitric_oxide_synthase	0,31	iNOS	Inducible nitric oxide synthase	4843	4843	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression may predict distant metastasis in human melanoma .
10779146	0	iNOS	33,37	Inducible_nitric_oxide_synthase	0,31	iNOS	Inducible nitric oxide synthase	4843	4843	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression in liver and splenic T lymphocyte rise are associated with liver histological damage during experimental hepatitis_A_virus _ -LRB- HAV -RRB- _ infection in Callithrix_jacchus .
11971212	0	iNOS	33,37	Inducible_nitric_oxide_synthase	0,31	iNOS	Inducible nitric oxide synthase	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression is increased in lipopolysaccharide -LRB- LPS -RRB- - stimulated diabetic rat glomeruli : effect of ACE inhibitor and angiotensin_II receptor blocker .
12533668	0	iNOS	151,155	MDA-7	135,140	iNOS	MDA-7	4843	11009	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Negative association of melanoma differentiation-associated gene -LRB- mda-7 -RRB- and inducible nitric_oxide synthase -LRB- iNOS -RRB- in human melanoma : MDA-7 regulates iNOS expression in melanoma cells .
12665503	0	iNOS	67,71	Myoglobin	0,9	iNOS	Myoglobin	18126(Tax:10090)	17189(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Myoglobin protects the heart from inducible_nitric-oxide_synthase -LRB- iNOS -RRB- - mediated nitrosative stress .
15217752	0	iNOS	55,59	NF-KB	101,106	iNOS	NF-KB	24599(Tax:10116)	81736(Tax:10116)	Gene	Gene	START_ENTITY|nmod|translocation translocation|amod|END_ENTITY	p38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells .
21162919	0	iNOS	40,44	NF-kB	14,19	iNOS	NF-kB	24599(Tax:10116)	81736(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	-LSB- Dual role of NF-kB and its target gene iNOS in cerebral ischemic tolerance induced by focal ischemic preconditioning -RSB- .
19317804	0	iNOS	19,23	NF-kappaB	0,9	iNOS	NF-kappaB	4843	4790	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	NF-kappaB promotes iNOS and VEGF expression in salivary gland adenoid_cystic_carcinoma cells and enhances endothelial cell motility in vitro .
9824673	0	iNOS	25,29	NF-kappaB	14,23	iNOS	NF-kappaB	4843	4790	Gene	Gene	START_ENTITY|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of NF-kappaB , iNOS mRNA , COX2 mRNA , and COX catalytic activity by phenyl-N-tert-butylnitrone -LRB- PBN -RRB- .
12672017	0	iNOS	90,94	NF-kappa_B	62,72	iNOS	NF-kappa B	18126(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	p75_neurotrophin_receptor mediates neurotrophin activation of NF-kappa_B and induction of iNOS expression in P19 neurons .
22349263	0	iNOS	98,102	Oct-1	0,5	iNOS	Oct-1	4843	6580	Gene	Gene	transcription|nmod|START_ENTITY control|dobj|transcription cooperates|xcomp|control cooperates|nsubj|END_ENTITY	Oct-1 cooperates with the TATA binding initiation complex to control rapid transcription of human iNOS .
26271992	0	iNOS	40,44	Oct-1	130,135	iNOS	Oct-1	4843	5451	Gene	Gene	promoter|amod|START_ENTITY Oct-1|nmod|promoter complex|nmod|Oct-1 transcription|amod|complex forms|dobj|transcription forms|advcl|interfering interfering|nmod|END_ENTITY	Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1 .
26271992	0	iNOS	40,44	Oct-1	27,32	iNOS	Oct-1	4843	5451	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1 .
19279235	0	iNOS	57,61	Oct-2	22,27	iNOS	Oct-2	4843	5452	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	The essential role of Oct-2 in LPS-induced expression of iNOS in RAW 264.7 macrophages and its regulation by trichostatin_A .
26271992	0	iNOS	40,44	Oct-2	0,5	iNOS	Oct-2	4843	5452	Gene	Gene	promoter|amod|START_ENTITY Oct-1|nmod|promoter complex|nmod|Oct-1 transcription|amod|complex forms|dobj|transcription forms|nsubj|END_ENTITY	Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1 .
12421638	0	iNOS	87,91	P38	0,3	iNOS	P38	4843	1432	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression has|dobj|effect inhibitor|ccomp|has inhibitor|nsubj|kinase kinase|nummod|END_ENTITY	P38 mitogen-activated protein kinase inhibitor SB203580 has a bi-directional effect on iNOS expression and NO production .
22155741	0	iNOS	45,49	P38	112,115	iNOS	P38	18126(Tax:10090)	26416(Tax:10090)	Gene	Gene	up-regulation|amod|START_ENTITY inhibits|dobj|up-regulation inhibits|advcl|suppressing suppressing|dobj|activation activation|compound|END_ENTITY	Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264 .7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge .
19670249	0	iNOS	20,24	Prostasin	0,9	iNOS	Prostasin	51477	5652	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Prostasin regulates iNOS and cyclin_D1 expression by modulating protease-activated_receptor-2 signaling in prostate epithelial cells .
11161462	0	iNOS	22,26	STAT1	0,5	iNOS	STAT1	18126(Tax:10090)	20846(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	STAT1 is required for iNOS activation , but not IL-6 production in murine fibroblasts .
22342441	0	iNOS	210,214	TNF-a	177,182	iNOS	TNF-a	18126(Tax:10090)	21926(Tax:10090)	Gene	Gene	cytokines|dep|START_ENTITY cytokines|appos|END_ENTITY	Inhibitory effects of bioactive leads isolated from Pseudomonas_aeruginosa PS3 and Pseudomonas_fluorescens PS7 on MAP kinases and down regulation of pro inflammatory cytokines -LRB- TNF-a , IL-1b -RRB- and mediators -LRB- NO , iNOS and COX -RRB- .
23886206	0	iNOS	90,94	TNF-a	83,88	iNOS	TNF-a	18126(Tax:10090)	21926(Tax:10090)	Gene	Gene	IL-2|appos|START_ENTITY IL-2|compound|END_ENTITY	Acacia ferruginea inhibits tumor progression by regulating inflammatory mediators - -LRB- TNF-a , iNOS , COX-2 , IL-1b , IL-6 , IFN-y , IL-2 , GM-CSF -RRB- and pro-angiogenic growth factor - VEGF .
25423092	0	iNOS	79,83	TNF-a	72,77	iNOS	TNF-a	18126(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Gentiolactone , a secoiridoid_dilactone from Gentiana triflora , inhibits TNF-a , iNOS and Cox-2 mRNA expression and blocks NF-kB promoter activity in murine macrophages .
26690069	0	iNOS	48,52	TNF-a	70,75	iNOS	TNF-a	18126(Tax:10090)	21926(Tax:10090)	Gene	Gene	synthase|appos|START_ENTITY Correlation|nmod|synthase inhibition|nsubj|Correlation inhibition|nmod|END_ENTITY	Correlation of inducible nitric_oxide synthase -LRB- iNOS -RRB- inhibition with TNF-a , caspase-1 , FasL and TLR-3 in pathogenesis of rabies in mouse model .
19802525	0	iNOS	20,24	TNF-alpha	0,9	iNOS	TNF-alpha	24599(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis .
11095498	0	iNOS	75,79	Tumor_necrosis_factor-alpha	0,27	iNOS	Tumor necrosis factor-alpha	4843	7124	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha and nerve growth factor synergistically induce iNOS in pheochromocytoma cells .
21857957	0	iNOS	20,24	UCP2	12,16	iNOS	UCP2	18126(Tax:10090)	22228(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Deletion of UCP2 in iNOS deficient mice reduces the severity of the disease during experimental autoimmune encephalomyelitis .
11321512	0	iNOS	42,46	VEGF	48,52	iNOS	VEGF	24599(Tax:10116)	83785(Tax:10116)	Gene	Gene	Relation|appos|START_ENTITY END_ENTITY|nsubj|Relation	Relation between expression of TNF_alpha , iNOS , VEGF mRNA and development of heart_failure after experimental myocardial_infarction in rats .
15050899	0	iNOS	79,83	VEGF	67,71	iNOS	VEGF	24599(Tax:10116)	83785(Tax:10116)	Gene	Gene	genes|appos|START_ENTITY genes|appos|END_ENTITY	Activation of the transcription factor HIF-1 and its target genes , VEGF , HO-1 , iNOS , during fracture repair .
19300368	0	iNOS	40,44	VEGF	46,50	iNOS	VEGF	4843	7422	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of pro-inflammatory protein , iNOS , VEGF and COX-2 in oral_squamous_cell_carcinoma -LRB- OSCC -RRB- , relationship with angiogenesis and their clinico-pathological correlation .
19307105	0	iNOS	96,100	VEGF	14,18	iNOS	VEGF	4843	7422	Gene	Gene	gene|amod|START_ENTITY Inhibition|nmod|gene Inhibition|nmod|expression expression|compound|END_ENTITY	Inhibition of VEGF expression in tongue_squamous_cancer cells via RNA interference silencing of iNOS gene .
25065562	0	iNOS	98,102	VEGF	29,33	iNOS	VEGF	4843	7422	Gene	Gene	RNAi|compound|START_ENTITY cells|nmod|RNAi study|nmod|cells study|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	A study on the inhibition of VEGF expression in salivary_gland_adenoid_cystic_carcinoma cells via iNOS gene RNAi in vitro .
26635115	0	iNOS	93,97	VEGF	50,54	iNOS	VEGF	4843	7422	Gene	Gene	Vascular_Endothelial_Growth_Factor|appos|START_ENTITY Vascular_Endothelial_Growth_Factor|appos|END_ENTITY	Uncoupling of Vascular_Endothelial_Growth_Factor -LRB- VEGF -RRB- and Inducible Nitric_Oxide Synthase -LRB- iNOS -RRB- in Gingival Tissue of Type 2 Diabetic Patients .
15013857	0	iNOS	58,62	YC-1_and_PMC	25,37	iNOS	YC-1 and PMC	24599(Tax:10116)	24421(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	Inhibitory mechanisms of YC-1_and_PMC in the induction of iNOS expression by lipoteichoic acid in RAW 264.7 macrophages .
19835666	0	iNOS	65,69	cox-1	59,64	iNOS	cox-1	4843	5742	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Autoantibodies from schizophrenia patients induce cerebral cox-1 / iNOS mRNA expression with NO/PGE2/MMP -3 production .
11526986	0	iNOS	16,20	eIF-2alpha	55,65	iNOS	eIF-2alpha	24599(Tax:10116)	502531(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model .
18391571	0	iNOS	8,12	endothelin-1	45,57	iNOS	endothelin-1	18126(Tax:10090)	13614(Tax:10090)	Gene	Gene	Lack|nmod|START_ENTITY impairs|nsubj|Lack impairs|dobj|function function|nmod|transgenic_mice transgenic_mice|amod|END_ENTITY	Lack of iNOS impairs endothelial function in endothelin-1 transgenic_mice .
18758499	0	iNOS	51,55	endothelin-1	27,39	iNOS	endothelin-1	18126(Tax:10090)	13614(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|pathway pathway|amod|END_ENTITY	Distinct modulation of the endothelin-1 pathway in iNOS - / - and eNOS - / - mice .
10385249	0	iNOS	42,46	erythropoietin	18,32	iNOS	erythropoietin	4843	2056	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Recombinant human erythropoietin inhibits iNOS activity and reverts vascular_dysfunction in splanchnic_artery_occlusion shock .
12669515	0	iNOS	15,19	iNOS	38,42	iNOS	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of iNOS and activities of iNOS and cNOS in right and left ventricles of the isolated heart during ischemia and reperfusion -RSB- .
12669515	0	iNOS	38,42	iNOS	15,19	iNOS	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of iNOS and activities of iNOS and cNOS in right and left ventricles of the isolated heart during ischemia and reperfusion -RSB- .
7542498	0	iNOS	61,65	iNOS	91,95	iNOS	iNOS	4843	4843	Gene	Gene	synthase|appos|START_ENTITY END_ENTITY|nsubj|synthase	Human mononuclear phagocyte inducible nitric_oxide synthase -LRB- iNOS -RRB- : analysis of iNOS mRNA , iNOS protein , biopterin , and nitric_oxide production by blood monocytes and peritoneal macrophages .
7542498	0	iNOS	91,95	iNOS	61,65	iNOS	iNOS	4843	4843	Gene	Gene	START_ENTITY|nsubj|synthase synthase|appos|END_ENTITY	Human mononuclear phagocyte inducible nitric_oxide synthase -LRB- iNOS -RRB- : analysis of iNOS mRNA , iNOS protein , biopterin , and nitric_oxide production by blood monocytes and peritoneal macrophages .
18596035	0	iNOS	127,131	inducible_nitric-oxide_synthase	94,125	iNOS	inducible nitric-oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible_nitric-oxide_synthase -LRB- iNOS -RRB- gene .
9195984	0	iNOS	62,66	inducible_nitric-oxide_synthase	29,60	iNOS	inducible nitric-oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mechanisms of suppression of inducible_nitric-oxide_synthase -LRB- iNOS -RRB- expression in interferon _ -LRB- IFN -RRB- - gamma-stimulated RAW 264.7 cells by dexamethasone .
10334391	0	iNOS	78,82	inducible_nitric_oxide_synthase	45,76	iNOS	inducible nitric oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Transcriptional basis for the differences in inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression between nonmetastatic and metastatic murine melanoma cell lines .
10774613	0	iNOS	47,51	inducible_nitric_oxide_synthase	14,45	iNOS	inducible nitric oxide synthase	443078(Tax:9940)	443078(Tax:9940)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	The effect of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- inhibition on smoke inhalation_injury in sheep .
11216878	0	iNOS	75,79	inducible_nitric_oxide_synthase	42,73	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Differential expression and regulation of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA in human trophoblasts in vitro .
11220644	0	iNOS	47,51	inducible_nitric_oxide_synthase	14,45	iNOS	inducible nitric oxide synthase	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- prevents lung neutrophil deposition and damage in burned rats .
11424980	0	iNOS	74,78	inducible_nitric_oxide_synthase	41,72	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	No evidence for involvement of the human inducible_nitric_oxide_synthase -LRB- iNOS -RRB- gene in susceptibility to typical migraine .
12654089	0	iNOS	47,51	inducible_nitric_oxide_synthase	14,45	iNOS	inducible nitric oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA in target organs of lethal and non-lethal strains of murine malaria .
14516401	0	iNOS	52,56	inducible_nitric_oxide_synthase	19,50	iNOS	inducible nitric oxide synthase	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in rat with congenital hydronephrosis .
14732335	0	iNOS	99,103	inducible_nitric_oxide_synthase	66,97	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Protein_kinase_C-eta -LRB- PKC-eta -RRB- is required for the development of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- positive phenotype in human monocytic cells .
15086905	0	iNOS	76,80	inducible_nitric_oxide_synthase	43,74	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Advanced_glycosylation end products induce inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via a p38 MAPK-dependent pathway .
15234218	0	iNOS	43,47	inducible_nitric_oxide_synthase	10,41	iNOS	inducible nitric oxide synthase	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Selective inducible_nitric_oxide_synthase -LRB- iNOS -RRB- inhibition attenuates remote acute_lung_injury in a model of ruptured_abdominal_aortic_aneurysm .
15338679	0	iNOS	55,59	inducible_nitric_oxide_synthase	22,53	iNOS	inducible nitric oxide synthase	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The potential role of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- activity in the testicular_dysfunction associated with varicocele : an experimental study .
16091294	0	iNOS	72,76	inducible_nitric_oxide_synthase	39,70	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Repression of interferon-gamma-induced inducible_nitric_oxide_synthase -LRB- iNOS -RRB- gene expression in microglia by sodium_butyrate is mediated through specific inhibition of ERK signaling pathways .
16362227	0	iNOS	72,76	inducible_nitric_oxide_synthase	39,70	iNOS	inducible nitric oxide synthase	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Evaluation of the relationship between inducible_nitric_oxide_synthase -LRB- iNOS -RRB- activity and effects of melatonin in experimental osteoporosis in the rat .
16417967	0	iNOS	51,55	inducible_nitric_oxide_synthase	18,49	iNOS	inducible nitric oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Manganese induces inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells .
16530791	0	iNOS	58,62	inducible_nitric_oxide_synthase	25,56	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Tumour overexpression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126 .
16584775	0	iNOS	124,128	inducible_nitric_oxide_synthase	91,122	iNOS	inducible nitric oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Identification of a regulatory cis-element within the 3 ' - untranslated region of the murine inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA ; interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the iNOS gene expression .
19404589	0	iNOS	51,55	inducible_nitric_oxide_synthase	18,49	iNOS	inducible nitric oxide synthase	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in the testis and epididymis of rats with a dihydrotestosterone -LRB- DHT -RRB- deficiency .
21251970	0	iNOS	113,117	inducible_nitric_oxide_synthase	80,111	iNOS	inducible nitric oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression in RAW 264.7 cells .
23471078	0	iNOS	39,43	inducible_nitric_oxide_synthase	6,37	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Human inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression depends on chromosome_region_maintenance_1 -LRB- CRM1 -RRB- - and eukaryotic_translation_initiation_factor_4E -LRB- elF4E -RRB- - mediated nucleocytoplasmic mRNA transport .
24858340	0	iNOS	46,50	inducible_nitric_oxide_synthase	13,44	iNOS	inducible nitric oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Induction of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression by oxLDL inhibits macrophage derived foam cell migration .
9421860	0	iNOS	117,121	inducible_nitric_oxide_synthase	84,115	iNOS	inducible nitric oxide synthase	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Streptococcal pyrogenic exotoxins A -LRB- SpeA -RRB- and C -LRB- SpeC -RRB- stimulate the production of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- protein in RAW 264.7 macrophages .
9625130	0	iNOS	47,51	inducible_nitric_oxide_synthase	14,45	iNOS	inducible nitric oxide synthase	4843	4843	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA in inflamed esophageal and colonic mucosa in a pediatric population .
9018086	0	iNOS	13,17	interferon-gamma	26,42	iNOS	interferon-gamma	4843	3458	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Induction of iNOS mRNA by interferon-gamma in epithelial cells is associated with growth_arrest and differentiation .
15845578	0	iNOS	84,88	interleukin-6	57,70	iNOS	interleukin-6	4843	3569	Gene	Gene	exposure|nmod|START_ENTITY exposure|amod|END_ENTITY	Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes .
24117944	0	iNOS	104,108	nNOS	129,133	iNOS	nNOS	18126(Tax:10090)	18125(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The beneficial effects of melatonin against heart mitochondrial impairment during sepsis : inhibition of iNOS and preservation of nNOS .
16033420	0	iNOS	66,70	neutral_sphingomyelinase	79,103	iNOS	neutral sphingomyelinase	4843	6610	Gene	Gene	enhances|dobj|START_ENTITY enhances|nmod|END_ENTITY	Amyloid-beta peptide enhances tumor_necrosis_factor-alpha-induced iNOS through neutral_sphingomyelinase / ceramide pathway in oligodendrocytes .
10447723	0	iNOS	82,86	p38	15,18	iNOS	p38	4843	1432	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Involvement Involvement|nmod|protein protein|amod|END_ENTITY	Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages .
10644515	0	iNOS	67,71	p38	76,79	iNOS	p38	24599(Tax:10116)	81649(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation .
15086905	0	iNOS	76,80	p38	99,102	iNOS	p38	4843	1432	Gene	Gene	expression|appos|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Advanced_glycosylation end products induce inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via a p38 MAPK-dependent pathway .
15217752	0	iNOS	55,59	p38	0,3	iNOS	p38	24599(Tax:10116)	81649(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|MAPK MAPK|compound|END_ENTITY	p38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells .
18289732	0	iNOS	130,134	p38	14,17	iNOS	p38	24599(Tax:10116)	81649(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY astrocytes|nmod|activation rat|dobj|astrocytes rat|nsubj|Activation Activation|nmod|MAPK MAPK|amod|END_ENTITY	Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase .
19055030	0	iNOS	45,49	p38	12,15	iNOS	p38	4843	1432	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression MAPK|nmod|induction MAPK|nsubj|Role Role|nmod|END_ENTITY	Role of the p38 MAPK pathway in induction of iNOS expression in human leukocytes .
19576750	0	iNOS	15,19	p38	72,75	iNOS	p38	4843	1432	Gene	Gene	expression|amod|START_ENTITY Suppression|nmod|expression mediated|nsubjpass|Suppression mediated|nmod|regulation regulation|nmod|MAPK MAPK|amod|END_ENTITY	Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK , JAK/STAT , AP-1 and IRF-1 , and depends on up-regulation of scavenger_receptor_B1 expression in TNF-alpha - and IFN-gamma-stimulated C6 glioma cells .
23856614	0	iNOS	90,94	p38	115,118	iNOS	p38	4843	5594	Gene	Gene	inhibition|nmod|START_ENTITY showed|nmod|inhibition showed|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Vorinostat , a HDAC inhibitor , showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression , p38 and ERK phosphorylation and blocking NF-kB nuclear translocation .
10842159	0	iNOS	33,37	p53	199,202	iNOS	p53	24599(Tax:10116)	301300(Tax:10116)	Gene	Gene	upregulates|appos|START_ENTITY vascular|nsubj|upregulates vascular|nmod|kinase kinase|nmod|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic_guanosine_monophosphate .
12100521	0	iNOS	7,11	p53	13,16	iNOS	p53	4843	7157	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	Bcl-2 , iNOS , p53 and PCNA expression in normal , disordered proliferative , hyperplastic and malignant endometrium .
21158070	0	iNOS	27,31	urotensin_II	11,23	iNOS	urotensin II	4843	10911	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of urotensin_II on iNOS expression in human umbilical vein endothelial cells -RSB- .
22246777	0	iRhom2	41,47	TACE	89,93	iRhom2	TACE	217344(Tax:10090)	11491(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|promote promote|dobj|trafficking trafficking|nmod|END_ENTITY	Tumor_necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE .
22246778	0	iRhom2	0,6	TACE	21,25	iRhom2	TACE	217344(Tax:10090)	11491(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS .
10934190	1	i_kappa_b_alpha	107,122	NF-kappa_B	168,178	i kappa b alpha	NF-kappa B	4792	4790	Gene	Gene	release|nmod|START_ENTITY results|nsubj|release results|nmod|binding binding|nmod|homologue homologue|nmod|END_ENTITY	Signal-induced release of i_kappa_b_alpha results in binding of the viral homologue to NF-kappa_B .
7713434	0	iab-5	20,25	bithorax_complex	44,60	iab-5	bithorax complex	47763(Tax:7227)	42034(Tax:7227)	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Transvection in the iab-5 ,6,7 region of the bithorax_complex of Drosophila : homology independent interactions in trans .
11158316	0	iab-7	4,9	polycomb	10,18	iab-7	polycomb	47763(Tax:7227)	40358(Tax:7227)	Gene	Gene	response|amod|START_ENTITY response|compound|END_ENTITY	The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity .
12399311	0	iab-8	50,55	Abdominal-B	81,92	iab-8	Abdominal-B	12798430	47763(Tax:7227)	Gene	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Genetic and molecular characterization of a novel iab-8 regulatory domain in the Abdominal-B gene of Drosophila_melanogaster .
21607299	0	icam-1	37,43	tnf-alpha	96,105	icam-1	tnf-alpha	3383	7124	Gene	Gene	molecules|amod|START_ENTITY Shedding|nmod|molecules Shedding|nmod|treatment treatment|nmod|END_ENTITY	Shedding of tnf-receptor and soluble icam-1 molecules in response to treatment with recombinant tnf-alpha and IFN-gamma in patients with colorectal-cancer .
10571944	0	iduronate-2-sulfatase	43,64	IDS	66,69	iduronate-2-sulfatase	IDS	3423	3423	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel type of genetic rearrangement in the iduronate-2-sulfatase -LRB- IDS -RRB- gene involving deletion , duplications , and inversions .
11462244	0	iduronate-2-sulfatase	99,120	IDS	122,125	iduronate-2-sulfatase	IDS	3423	3423	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of 40 Italian patients with mucopolysaccharidosis_type_II : New mutations in the iduronate-2-sulfatase -LRB- IDS -RRB- gene .
7981716	0	iduronate-2-sulfatase	17,38	IDS	40,43	iduronate-2-sulfatase	IDS	3423	3423	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations of the iduronate-2-sulfatase -LRB- IDS -RRB- gene in patients with Hunter_syndrome -LRB- mucopolysaccharidosis_II -RRB- .
8530090	0	iduronate-2-sulfatase	59,80	IDS	82,85	iduronate-2-sulfatase	IDS	3423	3423	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of an alternative transcript from the human iduronate-2-sulfatase -LRB- IDS -RRB- gene .
9921913	0	iduronate-2-sulfatase	27,48	IDS	50,53	iduronate-2-sulfatase	IDS	3423	3423	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational spectrum of the iduronate-2-sulfatase -LRB- IDS -RRB- gene in 36 unrelated Russian MPS_II patients .
24454794	0	iduronate-2-sulfatase	32,53	Idursulfase	55,66	iduronate-2-sulfatase	Idursulfase	3423	3423	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of recombinant human iduronate-2-sulfatase -LRB- Idursulfase -RRB- on growth in young patients with mucopolysaccharidosis_type_II .
8244397	0	iduronate_2-sulfatase	22,43	IDS	45,48	iduronate 2-sulfatase	IDS	3423	3423	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence of the human iduronate_2-sulfatase -LRB- IDS -RRB- gene .
19517571	0	ift57	10,15	ift88	17,22	ift57	ift88	414929(Tax:7955)	321855(Tax:7955)	Gene	Gene	Zebrafish|nummod|START_ENTITY Zebrafish|nummod|END_ENTITY	Zebrafish ift57 , ift88 , and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling .
19517571	0	ift88	17,22	ift57	10,15	ift88	ift57	321855(Tax:7955)	414929(Tax:7955)	Gene	Gene	Zebrafish|nummod|START_ENTITY Zebrafish|nummod|END_ENTITY	Zebrafish ift57 , ift88 , and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling .
16340214	0	igf-I	11,16	growth_hormone	175,189	igf-I	growth hormone	3479	2688	Gene	Gene	responsiveness|compound|START_ENTITY increased|nsubjpass|responsiveness increased|advcl|adults adults|nmod|deficiency deficiency|compound|END_ENTITY	Individual igf-I responsiveness to a fixed regimen of low-dose growth_hormone replacement is increased with less variability in obese compared to non-obese adults with severe growth_hormone deficiency .
16340214	0	igf-I	11,16	growth_hormone	63,77	igf-I	growth hormone	3479	2688	Gene	Gene	responsiveness|compound|START_ENTITY responsiveness|nmod|regimen regimen|nmod|replacement replacement|compound|END_ENTITY	Individual igf-I responsiveness to a fixed regimen of low-dose growth_hormone replacement is increased with less variability in obese compared to non-obese adults with severe growth_hormone deficiency .
14585811	0	igf-I	65,70	insulin-like_growth_factor-I	35,63	igf-I	insulin-like growth factor-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Development of leydig cells in the insulin-like_growth_factor-I -LRB- igf-I -RRB- knockout mouse : effects of igf-I replacement and gonadotropic stimulation .
17410466	0	igf-I	54,59	insulin-like_growth_factor-I	24,52	igf-I	insulin-like growth factor-I	3479	3479	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of insulin-like_growth_factor-I -LRB- igf-I -RRB- as a marker of liver_fibrosis in patients with chronic hepatitis_C .
23599716	0	igf-I	62,67	insulin-like_growth_factor-I	32,60	igf-I	insulin-like growth factor-I	3479	3479	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	A survey of correlation between insulin-like_growth_factor-I -LRB- igf-I -RRB- levels and severity of liver_cirrhosis .
25472129	0	igf2	52,56	insulin-like_growth_factor_2	22,50	igf2	insulin-like growth factor 2	281240(Tax:9913)	281240(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	80 DNA methylation of insulin-like_growth_factor_2 -LRB- igf2 -RRB- gene in day 14 in vitro-produced bovine embryos of different sizes .
16630821	0	ihog	4,8	Hedgehog	36,44	ihog	Hedgehog	33972(Tax:7227)	42737(Tax:7227)	Gene	Gene	bind|amod|START_ENTITY bind|acl|END_ENTITY	The ihog cell-surface proteins bind Hedgehog and mediate pathway activation .
11955625	0	ik3-2	0,5	cdk3	54,58	ik3-2	cdk3	81928	1018	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	ik3-2 , a relative to ik3-1 / cables , is associated with cdk3 , cdk5 , and c-abl .
10801783	0	il1b	41,45	NF-IL6	0,6	il1b	NF-IL6	3553	1051	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	NF-IL6 -LRB- C/EBPbeta -RRB- vigorously activates il1b gene expression via a Spi-1 _ -LRB- PU .1 -RRB- protein-protein tether .
14770367	0	ileal_bile_acid-binding_protein	8,39	I-BABP	41,47	ileal bile acid-binding protein	I-BABP	2172	2172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Is the ileal_bile_acid-binding_protein -LRB- I-BABP -RRB- gene involved in cholesterol homeostasis ? -RSB- .
9200067	0	immediate_early	195,210	IE	212,214	immediate early	IE	16476(Tax:10090)	16476(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Differences in resistance to herpes_simplex_virus_type_1 -LRB- HSV-1 -RRB- among oligodendroglia derived from different strains of mice are determined after viral adsorption but prior to the expression of immediate_early -LRB- IE -RRB- genes .
26101708	0	immediate_early_response_protein_2	73,107	miR-30c	0,7	immediate early response protein 2	miR-30c	9592	407031	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-30c negatively regulates the migration and invasion by targeting the immediate_early_response_protein_2 in SMMC-7721 and HepG2 cells .
15379978	0	immunoglobulin_A	53,69	CD89	47,51	immunoglobulin A	CD89	973	2204	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Identification and characterization of macaque CD89 -LRB- immunoglobulin_A Fc receptor -RRB- .
9870466	0	immunoglobulin_A	19,35	CD89	117,121	immunoglobulin A	CD89	973	2204	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
12354881	0	immunoglobulin_A	45,61	IgA	63,66	immunoglobulin A	IgA	973	973	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Serodiagnosis of tuberculosis : comparison of immunoglobulin_A -LRB- IgA -RRB- response to sulfolipid_I with IgG and IgM responses to 2,3-diacyltrehalose , 2,3,6-triacyltrehalose , and cord factor antigens .
1921736	0	immunoglobulin_A	8,24	IgA	26,29	immunoglobulin A	IgA	973	973	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Vaginal immunoglobulin_A -LRB- IgA -RRB- levels in post-menopausal women : influence of oestriol therapy .
9870466	0	immunoglobulin_A	19,35	IgA	37,40	immunoglobulin A	IgA	973	973	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Reduced binding of immunoglobulin_A -LRB- IgA -RRB- from patients with primary IgA nephropathy to the myeloid IgA Fc-receptor , CD89 .
12704129	0	immunoglobulin_A1	22,39	IgA1	41,45	immunoglobulin A1	IgA1	3493	3493	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Cleavage of the human immunoglobulin_A1 -LRB- IgA1 -RRB- hinge region by IgA1 proteases requires structures in the Fc region of IgA .
22815482	0	immunoglobulin_E	36,52	CD23	15,19	immunoglobulin E	CD23	3497	2208	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Mapping of the CD23 binding site on immunoglobulin_E -LRB- IgE -RRB- and allosteric control of the IgE-Fc epsilonRI interaction .
8294882	0	immunoglobulin_E	39,55	Fc_epsilon_RI	67,80	immunoglobulin E	Fc epsilon RI	3497	2205	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Expression of functional high affinity immunoglobulin_E receptors -LRB- Fc_epsilon_RI -RRB- on monocytes of atopic individuals .
10413189	0	immunoglobulin_E	9,25	IgE	27,30	immunoglobulin E	IgE	3497	3497	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Elevated immunoglobulin_E -LRB- IgE -RRB- levels in children with exposure to environmental lead .
15807855	0	immunoglobulin_E	54,70	IgE	72,75	immunoglobulin E	IgE	3497	3497	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Different natural_killer _ -LRB- NK -RRB- _ receptor expression and immunoglobulin_E -LRB- IgE -RRB- regulation by NK1 and NK2 cells .
23198022	0	immunoglobulin_E	6,22	IgE	24,27	immunoglobulin E	IgE	3497	3497	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum immunoglobulin_E -LRB- IgE -RRB- levels and dietary intake of Korean infants and young children with atopic_dermatitis .
6846921	0	immunoglobulin_E	9,25	IgE	27,30	immunoglobulin E	IgE	3497	3497	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	Value of immunoglobulin_E -LRB- IgE -RRB- in the private practice of allergy .
923104	0	immunoglobulin_E	10,26	IgE	28,31	immunoglobulin E	IgE	3497	3497	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of immunoglobulin_E -LRB- IgE -RRB- in paired examinations of serum and synovial fluid in rheumatoid_arthritis and reactive synovitis of local origin .
9381890	0	immunoglobulin_E	6,22	Ig_E	24,28	immunoglobulin E	Ig E	3497	3497	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Serum immunoglobulin_E -LRB- Ig_E -RRB- levels after myocardial_infarction .
1383379	0	immunoglobulin_E	42,58	Interleukin_8	0,13	immunoglobulin E	Interleukin 8	3497	3576	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- selectively inhibits immunoglobulin_E production induced by IL-4 in human B cells .
10852530	0	immunoglobulin_E	21,37	interleukin-5	6,19	immunoglobulin E	interleukin-5	3497	3567	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Nasal interleukin-5 , immunoglobulin_E , eosinophilic cationic protein , and soluble intercellular adhesion molecule-1 in chronic sinusitis , allergic_rhinitis , and nasal_polyposis .
8436904	0	immunoglobulin_E_receptor	92,117	IL-4	72,76	immunoglobulin E receptor	IL-4	2206	3565	Gene	Gene	stimulation|compound|START_ENTITY produce|nmod|stimulation produce|dobj|END_ENTITY	Human peripheral blood basophils primed by interleukin_3 _ -LRB- IL-3 -RRB- produce IL-4 in response to immunoglobulin_E_receptor stimulation .
18184825	0	immunoglobulin_G1	125,142	IgG2a	150,155	immunoglobulin G1	IgG2a	16017(Tax:10090)	668478(Tax:10090)	Gene	Gene	START_ENTITY|dep|ratio ratio|amod|END_ENTITY	Optimized immune response elicited by a DNA vaccine expressing pneumococcal_surface_protein_a is characterized by a balanced immunoglobulin_G1 -LRB- IgG1 -RRB- / IgG2a ratio and proinflammatory cytokine production .
11991851	0	immunoglobulin_e	37,53	IgE	55,58	immunoglobulin e	IgE	3497	3497	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Alcohol-induced alterations in serum immunoglobulin_e -LRB- IgE -RRB- levels in human subjects .
17639584	0	immunoglobulin_heavy-chain	14,40	IGH	42,45	immunoglobulin heavy-chain	IGH	238412(Tax:10090)	238412(Tax:10090)	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	In a model of immunoglobulin_heavy-chain -LRB- IGH -RRB- / MYC translocation , the Igh_3 ' regulatory region induces MYC expression at the immature stage of B cell development .
17639584	0	immunoglobulin_heavy-chain	14,40	MYC	47,50	immunoglobulin heavy-chain	MYC	238412(Tax:10090)	4609	Gene	Gene	translocation|amod|START_ENTITY translocation|compound|END_ENTITY	In a model of immunoglobulin_heavy-chain -LRB- IGH -RRB- / MYC translocation , the Igh_3 ' regulatory region induces MYC expression at the immature stage of B cell development .
9207027	0	immunoglobulin_heavy-chain_binding_protein	80,122	BiP	124,127	immunoglobulin heavy-chain binding protein	BiP	3309	3309	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Location of the internal ribosome entry site in the 5 ' non-coding region of the immunoglobulin_heavy-chain_binding_protein -LRB- BiP -RRB- mRNA : evidence for specific RNA-protein interactions .
16194898	0	immunoglobulin_heavy_chain	43,69	BCL2	17,21	immunoglobulin heavy chain	BCL2	3495	596	Gene	Gene	Translocation|nmod|START_ENTITY Translocation|nmod|END_ENTITY	Translocation of BCL2 and BCL6 to the same immunoglobulin_heavy_chain locus in a case of follicular_lymphoma .
9592350	0	immunoglobulin_heavy_chain	14,40	IgH	42,45	immunoglobulin heavy chain	IgH	3495	3495	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Detection of immunoglobulin_heavy_chain -LRB- IgH -RRB- gene rearrangement in ANLL by polymerase chain reaction amplification and Southern blot -RSB- .
6818551	0	immunoglobulin_heavy_chain	41,67	c-myc	21,26	immunoglobulin heavy chain	c-myc	3495	4609	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Translocation of the c-myc gene into the immunoglobulin_heavy_chain locus in human Burkitt_lymphoma and murine plasmacytoma cells .
3920661	0	immunoglobulin_heavy_chain_locus	63,95	Igh	58,61	immunoglobulin heavy chain locus	Igh	111507(Tax:10090)	111507(Tax:10090)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Suppressor T-cell factor -LRB- s -RRB- display an altered pattern of Igh -LRB- immunoglobulin_heavy_chain_locus -RRB- genetic restriction when developed in an Igh-congeneic host .
16920917	0	immunoglobulin_receptor	70,93	CD300b	45,51	immunoglobulin receptor	CD300b	80739	124599	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Molecular and functional characterization of CD300b , a new activating immunoglobulin_receptor able to transduce signals through two different pathways .
10512678	0	immunoglobulin_superfamily_containing_leucine-rich_repeat	22,79	ISLR	16,20	immunoglobulin superfamily containing leucine-rich repeat	ISLR	26968(Tax:10090)	26968(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Human and mouse ISLR -LRB- immunoglobulin_superfamily_containing_leucine-rich_repeat -RRB- genes : genomic structure and tissue expression .
26163525	0	immunoglobulin_superfamily_member_1	35,70	IGSF1	72,77	immunoglobulin superfamily member 1	IGSF1	302822(Tax:10116)	302822(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Spatial and temporal expression of immunoglobulin_superfamily_member_1 -LRB- IGSF1 -RRB- in the rat .
16681430	0	immunoglobulin_superfamily_receptor_translocation-associated_2	28,90	CD307	106,111	immunoglobulin superfamily receptor translocation-associated 2	CD307	83416	83416	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
16681430	0	immunoglobulin_superfamily_receptor_translocation-associated_2	28,90	FcRH5	99,104	immunoglobulin superfamily receptor translocation-associated 2	FcRH5	83416	83416	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
16681430	0	immunoglobulin_superfamily_receptor_translocation-associated_2	28,90	IRTA2	92,97	immunoglobulin superfamily receptor translocation-associated 2	IRTA2	83416	83416	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Sandwich ELISAs for soluble immunoglobulin_superfamily_receptor_translocation-associated_2 -LRB- IRTA2 -RRB- / FcRH5 -LRB- CD307 -RRB- proteins in human sera .
9807817	0	immunophilin	15,27	AtFIP37	48,55	immunophilin	AtFIP37	836556(Tax:3702)	824584(Tax:3702)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	An Arabidopsis immunophilin , AtFKBP12 , binds to AtFIP37 -LRB- FKBP interacting protein -RRB- in an interaction that is disrupted by FK506 .
3210023	0	immunosuppressive_acidic_protein	25,57	IAP	59,62	immunosuppressive acidic protein	IAP	3375	3375	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Intrathecal synthesis of immunosuppressive_acidic_protein -LRB- IAP -RRB- in patients with multiple_sclerosis and other inflammatory neurological_diseases .
3772394	0	immunosuppressive_acidic_protein	24,56	IAP	58,61	immunosuppressive acidic protein	IAP	84061	84061	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Significant increase in immunosuppressive_acidic_protein -LRB- IAP -RRB- in serum of patients with multiple_sclerosis and other inflammatory neurological_disorders .
6727048	0	immunosuppressive_acidic_protein	10,42	IAP	44,47	immunosuppressive acidic protein	IAP	3375	3375	Gene	Gene	Study|nmod|START_ENTITY Study|appos|END_ENTITY	-LSB- Study of immunosuppressive_acidic_protein -LRB- IAP -RRB- in patients with renal_cell_cancer -RSB- .
6749105	0	immunosuppressive_acidic_protein	17,49	IAP	51,54	immunosuppressive acidic protein	IAP	84061	84061	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	-LSB- Serum levels of immunosuppressive_acidic_protein -LRB- IAP -RRB- in various disease states and their clinical significance -RSB- .
17067994	0	implantin	23,32	ADAMTS-5	14,22	implantin	ADAMTS-5	23794(Tax:10090)	11096	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of ADAMTS-5 / implantin in human decidual stromal cells : regulatory effects of cytokines .
10100610	0	importin-alpha3	70,85	tissue_transglutaminase	15,38	importin-alpha3	tissue transglutaminase	3839	7052	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of tissue_transglutaminase with nuclear transport protein importin-alpha3 .
18656533	0	importin-beta	69,82	Ketel	92,97	importin-beta	Ketel	35336(Tax:7227)	35336(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The DRE motif is a key component in the expression regulation of the importin-beta encoding Ketel gene in Drosophila .
12019231	0	importin_alpha1	24,39	importin_alpha2	63,78	importin alpha1	importin alpha2	40160(Tax:7227)	34338(Tax:7227)	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	Drosophila_melanogaster importin_alpha1 and alpha3 can replace importin_alpha2 during spermatogenesis but not oogenesis .
12019231	0	importin_alpha2	63,78	importin_alpha1	24,39	importin alpha2	importin alpha1	34338(Tax:7227)	40160(Tax:7227)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	Drosophila_melanogaster importin_alpha1 and alpha3 can replace importin_alpha2 during spermatogenesis but not oogenesis .
18632986	0	ina-1	142,147	teneurin	23,31	ina-1	teneurin	176296(Tax:6239)	175953(Tax:6239)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Caenorhabditis_elegans teneurin , ten-1 , is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1 .
15164415	0	incontinentia_pigmenti	80,102	NEMO	58,62	incontinentia pigmenti	NEMO	8517	8517	Gene	Gene	rearrangement|nmod|START_ENTITY rearrangement|compound|END_ENTITY	A novel PCR approach for prenatal detection of the common NEMO rearrangement in incontinentia_pigmenti .
23344392	0	indoleamine_2-3_dioxygenase	12,39	IDO1	41,45	indoleamine 2-3 dioxygenase	IDO1	3620	3620	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of indoleamine_2-3_dioxygenase -LRB- IDO1 -RRB- expression in breast_cancer tissue by immunohistochemistry .
10882409	0	inducible_NO_synthase	40,61	IFN-gamma	0,9	inducible NO synthase	IFN-gamma	18126(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	IFN-gamma and IL-4 differently regulate inducible_NO_synthase gene expression through IRF-1 modulation .
11742864	0	inducible_NO_synthase	83,104	interleukin-1beta	50,67	inducible NO synthase	interleukin-1beta	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Persistent activation of nuclear factor-kappaB by interleukin-1beta and subsequent inducible_NO_synthase expression requires extracellular_signal-regulated_kinase .
9326591	0	inducible_T_cell_kinase	26,49	ITK	51,54	inducible T cell kinase	ITK	16428(Tax:10090)	16428(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Src-induced activation of inducible_T_cell_kinase -LRB- ITK -RRB- requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible_T_cell_kinase .
11002260	0	inducible_cAMP_early_repressor	78,108	ICER	110,114	inducible cAMP early repressor	ICER	1390	1390	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Repression of tax-mediated human_t-lymphotropic_virus_type_1 transcription by inducible_cAMP_early_repressor -LRB- ICER -RRB- protein in peripheral blood mononuclear cells .
8750826	0	inducible_cAMP_early_repressor	14,44	ICER	46,50	inducible cAMP early repressor	ICER	1390	1390	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of inducible_cAMP_early_repressor -LRB- ICER -RRB- in hypothalamic magnocellular neurons .
9359831	0	inducible_cAMP_early_repressor	19,49	ICER	51,55	inducible cAMP early repressor	ICER	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|appos|END_ENTITY	Degradation of the inducible_cAMP_early_repressor -LRB- ICER -RRB- by the ubiquitin-proteasome pathway .
9844102	0	inducible_cAMP_early_repressor	46,76	Parathyroid_hormone	0,19	inducible cAMP early repressor	Parathyroid hormone	12916(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Parathyroid_hormone induces expression of the inducible_cAMP_early_repressor in osteoblastic MC3T3-E1 cells and mouse calvariae .
10660591	0	inducible_cAMP_early_repressor	14,44	gastrin	59,66	inducible cAMP early repressor	gastrin	25620(Tax:10116)	25320(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of inducible_cAMP_early_repressor expression by gastrin and cholecystokinin in the pancreatic cell line AR42J .
12853164	0	inducible_co-stimulator	12,35	B7-related_protein-1	43,63	inducible co-stimulator	B7-related protein-1	54167(Tax:10090)	50723(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|parataxis|interaction interaction|nsubj|END_ENTITY	The role of inducible_co-stimulator -LRB- ICOS -RRB- / B7-related_protein-1 -LRB- B7RP-1 -RRB- interaction in the functional development of Peyer 's patches .
19125271	0	inducible_co-stimulator	19,42	ICOS	44,48	inducible co-stimulator	ICOS	64545(Tax:10116)	64545(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of inducible_co-stimulator -LRB- ICOS -RRB- by intravitreal injection of small interfering RNA -LRB- siRNA -RRB- plasmid suppresses ongoing experimental autoimmune uveoretinitis in rats .
14734605	0	inducible_co-stimulator	9,32	Th1	64,67	inducible co-stimulator	Th1	54167(Tax:10090)	57314(Tax:10090)	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Blocking inducible_co-stimulator in the absence of CD28 impairs Th1 and CD25 + regulatory T cells in murine colitis .
19776675	0	inducible_costimulator	31,53	B7-H2	61,66	inducible costimulator	B7-H2	29851	23308	Gene	Gene	Expression|nmod|START_ENTITY ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression and function of the inducible_costimulator ligand B7-H2 in human airway_smooth_muscle cells .
12039981	0	inducible_costimulator	74,96	B7RP-1	66,72	inducible costimulator	B7RP-1	29851	23308	Gene	Gene	ligand|compound|START_ENTITY END_ENTITY|appos|ligand	Renal tubular epithelial expression of the costimulatory molecule B7RP-1 -LRB- inducible_costimulator ligand -RRB- .
20116985	0	inducible_costimulator	61,83	CD4	14,17	inducible costimulator	CD4	29851	920	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|activation activation|compound|END_ENTITY	Regulation of CD4 T cell activation and effector function by inducible_costimulator -LRB- ICOS -RRB- .
20445113	0	inducible_costimulator	27,49	CD4	70,73	inducible costimulator	CD4	29851	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression and function of inducible_costimulator on peripheral blood CD4 + T cells in Beh et 's patients with uveitis : a new activity marker ?
21871023	0	inducible_costimulator	24,46	CD4	50,53	inducible costimulator	CD4	29851	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Ribavirin downmodulates inducible_costimulator on CD4 + T cells and their interleukin-10 secretion to assist in hepatitis_C virus clearance .
12753665	0	inducible_costimulator	25,47	ICOS	49,53	inducible costimulator	ICOS	29851	29851	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allelic variation of the inducible_costimulator -LRB- ICOS -RRB- gene : detection of polymorphisms , analysis of the promoter region , and extended haplotype estimation .
15941568	0	inducible_costimulator	22,44	ICOS	46,50	inducible costimulator	ICOS	54167(Tax:10090)	54167(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A functional role for inducible_costimulator -LRB- ICOS -RRB- in atherosclerosis .
16880206	0	inducible_costimulator	20,42	ICOS	44,48	inducible costimulator	ICOS	54167(Tax:10090)	54167(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of mouse inducible_costimulator -LRB- ICOS -RRB- expression by Fyn-NFATc2 and ERK signaling in T cells .
22884151	0	inducible_costimulator	101,123	Repressor_of_GATA-3	0,19	inducible costimulator	Repressor of GATA-3	29851	27033	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Repressor_of_GATA-3 can negatively regulate the expression of T cell cytokines through modulation on inducible_costimulator .
24100657	0	inducible_costimulator_ligand	9,38	ICOS-L	40,46	inducible costimulator ligand	ICOS-L	50723(Tax:10090)	50723(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Enhanced inducible_costimulator_ligand -LRB- ICOS-L -RRB- expression on dendritic cells in interleukin-10_deficiency and its impact on T-cell subsets in respiratory_tract_infection .
22706735	0	inducible_costimulator_ligand	15,44	ICOSL	46,51	inducible costimulator ligand	ICOSL	23308	23308	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Involvement of inducible_costimulator_ligand -LRB- ICOSL -RRB- expression in thyroid tissue in hyperthyroidism of Graves ' _ disease patients .
11801630	0	inducible_costimulator_protein	14,44	Th1	60,63	inducible costimulator protein	Th1	54167(Tax:10090)	57314(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	Cutting edge : inducible_costimulator_protein regulates both Th1 and Th2 responses to cutaneous_leishmaniasis .
11571308	0	inducible_costimulator_receptor	56,87	Tumor_necrosis_factor-alpha	0,27	inducible costimulator receptor	Tumor necrosis factor-alpha	29851	7124	Gene	Gene	cells|compound|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates the expression of inducible_costimulator_receptor ligand on CD34 -LRB- + -RRB- progenitor cells during differentiation into antigen presenting cells .
9881864	0	inducible_cyclic-AMP_early_repressor	81,117	cyclic-AMP_responsive_element_modulator	41,80	inducible cyclic-AMP early repressor	cyclic-AMP responsive element modulator	25620(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Plasticity - and neurodegeneration-linked cyclic-AMP_responsive_element_modulator / inducible_cyclic-AMP_early_repressor messenger RNA expression in the rat brain .
15384069	0	inducible_cyclicAMP_early_repressor	37,72	ICER	74,78	inducible cyclicAMP early repressor	ICER	1390	1390	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of transcription factor inducible_cyclicAMP_early_repressor -LRB- ICER -RRB- in rodent brain and pituitary .
18849323	0	inducible_heat_shock_protein_70	39,70	histone_deacetylase_2	14,35	inducible heat shock protein 70	histone deacetylase 2	193740(Tax:10090)	15182(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of histone_deacetylase_2 by inducible_heat_shock_protein_70 in cardiac_hypertrophy .
19074427	0	inducible_nitric-oxide_synthase	28,59	AUF1	120,124	inducible nitric-oxide synthase	AUF1	4843	3184	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Similar regulation of human inducible_nitric-oxide_synthase expression by different isoforms of the RNA-binding protein AUF1 .
17322004	0	inducible_nitric-oxide_synthase	41,72	Jun_N-terminal_kinase	91,112	inducible nitric-oxide synthase	Jun N-terminal kinase	4843	5599	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Post-transcriptional regulation of human inducible_nitric-oxide_synthase expression by the Jun_N-terminal_kinase .
15356214	0	inducible_nitric-oxide_synthase	119,150	PPARgamma	87,96	inducible nitric-oxide synthase	PPARgamma	18126(Tax:10090)	19016(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Peroxisome_proliferation-activated_receptor -LRB- PPAR -RRB- gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible_nitric-oxide_synthase and nitric_oxide .
16613848	0	inducible_nitric-oxide_synthase	17,48	RANKL	0,5	inducible nitric-oxide synthase	RANKL	18126(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	RANKL stimulates inducible_nitric-oxide_synthase expression and nitric_oxide production in developing osteoclasts .
18596035	0	inducible_nitric-oxide_synthase	94,125	iNOS	127,131	inducible nitric-oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible_nitric-oxide_synthase -LRB- iNOS -RRB- gene .
9195984	0	inducible_nitric-oxide_synthase	29,60	iNOS	62,66	inducible nitric-oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mechanisms of suppression of inducible_nitric-oxide_synthase -LRB- iNOS -RRB- expression in interferon _ -LRB- IFN -RRB- - gamma-stimulated RAW 264.7 cells by dexamethasone .
9305901	0	inducible_nitric-oxide_synthase	74,105	interferon_regulatory_factor-1	36,66	inducible nitric-oxide synthase	interferon regulatory factor-1	4843	3659	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Binding of the transcription factor interferon_regulatory_factor-1 to the inducible_nitric-oxide_synthase promoter .
15683732	0	inducible_nitric_oxide_synthase	122,153	Akt	75,78	inducible nitric oxide synthase	Akt	4843	207	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Trophoblast apoptosis is inhibited by hepatocyte_growth_factor through the Akt and beta-catenin mediated up-regulation of inducible_nitric_oxide_synthase .
11277613	0	inducible_nitric_oxide_synthase	26,57	Antithrombin_III	0,16	inducible nitric oxide synthase	Antithrombin III	4843	462	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Antithrombin_III enhances inducible_nitric_oxide_synthase gene expression in vascular smooth muscle cells .
14704000	0	inducible_nitric_oxide_synthase	25,56	Bax	66,69	inducible nitric oxide synthase	Bax	4843	581	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Correlated expression of inducible_nitric_oxide_synthase and P53 , Bax in benign and malignant diseased_gallbladder .
20228252	0	inducible_nitric_oxide_synthase	87,118	Beta-arrestin_2	0,15	inducible nitric oxide synthase	Beta-arrestin 2	4843	409	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Beta-arrestin_2 is required for B1_receptor-dependent post-translational activation of inducible_nitric_oxide_synthase .
25035167	0	inducible_nitric_oxide_synthase	87,118	CD4	64,67	inducible nitric oxide synthase	CD4	18126(Tax:10090)	12504(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	SSC -LRB- high -RRB- CD11b -LRB- high -RRB- Ly-6C -LRB- high -RRB- Ly-6G -LRB- low -RRB- myeloid cells curtail CD4 T cell response by inducible_nitric_oxide_synthase in murine hepatitis .
15498507	0	inducible_nitric_oxide_synthase	35,66	Catalase	0,8	inducible nitric oxide synthase	Catalase	18126(Tax:10090)	12359(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Catalase induces the expression of inducible_nitric_oxide_synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells .
11114180	0	inducible_nitric_oxide_synthase	26,57	Caveolin-1	0,10	inducible nitric oxide synthase	Caveolin-1	4843	857	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	Caveolin-1 down-regulates inducible_nitric_oxide_synthase via the proteasome pathway in human colon_carcinoma cells .
11518681	0	inducible_nitric_oxide_synthase	31,62	Cyclooxygenase-2	0,16	inducible nitric oxide synthase	Cyclooxygenase-2	24599(Tax:10116)	29527(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	Cyclooxygenase-2 downregulates inducible_nitric_oxide_synthase in rat intestinal epithelial cells .
21547253	0	inducible_nitric_oxide_synthase	47,78	Dual_specificity_phosphatase_1	0,30	inducible nitric oxide synthase	Dual specificity phosphatase 1	4843	1843	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Dual_specificity_phosphatase_1 regulates human inducible_nitric_oxide_synthase expression by p38 MAP kinase .
9374727	0	inducible_nitric_oxide_synthase	55,86	Extracellular_superoxide_dismutase	0,34	inducible nitric oxide synthase	Extracellular superoxide dismutase	24599(Tax:10116)	25352(Tax:10116)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Extracellular_superoxide_dismutase is upregulated with inducible_nitric_oxide_synthase after NF-kappa B activation .
10589693	0	inducible_nitric_oxide_synthase	38,69	Heme_oxygenase-1	0,16	inducible nitric oxide synthase	Heme oxygenase-1	4843	3162	Gene	Gene	START_ENTITY|nsubj|attenuates attenuates|amod|END_ENTITY	Heme_oxygenase-1 induction attenuates inducible_nitric_oxide_synthase expression and proteinuria in glomerulonephritis .
14576830	0	inducible_nitric_oxide_synthase	92,123	IL-1beta	50,58	inducible nitric oxide synthase	IL-1beta	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta - and lipopolysaccharide-mediated inducible_nitric_oxide_synthase expression in rat intestinal epithelial cells .
18348730	0	inducible_nitric_oxide_synthase	49,80	IL-1beta	32,40	inducible nitric oxide synthase	IL-1beta	4843	3553	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	Dynamic compression counteracts IL-1beta induced inducible_nitric_oxide_synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs .
9590244	0	inducible_nitric_oxide_synthase	24,55	IL-1beta	75,83	inducible nitric oxide synthase	IL-1beta	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Molecular mechanisms of inducible_nitric_oxide_synthase gene expression by IL-1beta and cAMP in rat mesangial cells .
18818879	0	inducible_nitric_oxide_synthase	28,59	Ikaros	0,6	inducible nitric oxide synthase	Ikaros	4843	10320	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ikaros negatively regulates inducible_nitric_oxide_synthase expression in macrophages : involvement of Ikaros phosphorylation by casein kinase 2 .
18818879	0	inducible_nitric_oxide_synthase	28,59	Ikaros	102,108	inducible nitric oxide synthase	Ikaros	4843	10320	Gene	Gene	expression|amod|START_ENTITY expression|dep|involvement involvement|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Ikaros negatively regulates inducible_nitric_oxide_synthase expression in macrophages : involvement of Ikaros phosphorylation by casein kinase 2 .
11724787	0	inducible_nitric_oxide_synthase	33,64	Integrin-linked_kinase	0,22	inducible nitric oxide synthase	Integrin-linked kinase	18126(Tax:10090)	16202(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Integrin-linked_kinase regulates inducible_nitric_oxide_synthase and cyclooxygenase-2 expression in an NF-kappa_B-dependent manner .
12774458	0	inducible_nitric_oxide_synthase	24,55	Interleukin-10	0,14	inducible nitric oxide synthase	Interleukin-10	24599(Tax:10116)	25325(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits inducible_nitric_oxide_synthase in an animal model of necrotizing_enterocolitis .
9931117	0	inducible_nitric_oxide_synthase	32,63	Interleukin-1beta	0,17	inducible nitric oxide synthase	Interleukin-1beta	4843	3553	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Interleukin-1beta regulation of inducible_nitric_oxide_synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes .
10229861	0	inducible_nitric_oxide_synthase	96,127	NF-IL6	37,43	inducible nitric oxide synthase	NF-IL6	18126(Tax:10090)	12608(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Central role of transcription factor NF-IL6 for cytokine and iron-mediated regulation of murine inducible_nitric_oxide_synthase expression .
7503239	0	inducible_nitric_oxide_synthase	40,71	NF-kappa_B	8,18	inducible nitric oxide synthase	NF-kappa B	18126(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY Role|nmod|regulation Role|nmod|END_ENTITY	Role of NF-kappa_B in the regulation of inducible_nitric_oxide_synthase in an MTAL cell line .
15275951	0	inducible_nitric_oxide_synthase	20,51	NOS2A	58,63	inducible nitric oxide synthase	NOS2A	4843	4843	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of an inducible_nitric_oxide_synthase gene -LRB- NOS2A -RRB- polymorphism in a multiple_sclerosis population .
21847581	0	inducible_nitric_oxide_synthase	51,82	Phosphatidylinositol_3-kinase	0,29	inducible nitric oxide synthase	Phosphatidylinositol 3-kinase	24599(Tax:10116)	298947(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Phosphatidylinositol_3-kinase inhibitor suppresses inducible_nitric_oxide_synthase expression in bronchiole epithelial cells in asthmatic rats .
16638913	0	inducible_nitric_oxide_synthase	21,52	Prostasin	0,9	inducible nitric oxide synthase	Prostasin	18126(Tax:10090)	5652	Gene	Gene	expression|amod|START_ENTITY attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Prostasin attenuates inducible_nitric_oxide_synthase expression in lipopolysaccharide-induced urinary bladder_inflammation .
9168934	0	inducible_nitric_oxide_synthase	19,50	TNF-alpha	0,9	inducible nitric oxide synthase	TNF-alpha	4843	7124	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	TNF-alpha mediates inducible_nitric_oxide_synthase expression in human neuroblastoma cell line by cisplatin .
19048467	0	inducible_nitric_oxide_synthase	47,78	Vascular_endothelial_growth_factor	0,34	inducible nitric oxide synthase	Vascular endothelial growth factor	24599(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor upregulates inducible_nitric_oxide_synthase expression in the muscle flap ischemia model in the rat .
11939728	0	inducible_nitric_oxide_synthase	121,152	cyclooxygenase-2	17,33	inducible nitric oxide synthase	cyclooxygenase-2	4843	5743	Gene	Gene	correlation|nmod|START_ENTITY Up-regulation|dep|correlation Up-regulation|nmod|expression expression|amod|END_ENTITY	Up-regulation of cyclooxygenase-2 expression in lymphocytic_thyroiditis_and_thyroid_tumors : significant correlation with inducible_nitric_oxide_synthase .
15740981	0	inducible_nitric_oxide_synthase	33,64	cyclooxygenase-2	92,108	inducible nitric oxide synthase	cyclooxygenase-2	24599(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|that that|nmod|pleurisy pleurisy|amod|END_ENTITY	Local and systemic expression of inducible_nitric_oxide_synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy .
16518418	0	inducible_nitric_oxide_synthase	147,178	cyclooxygenase-2	129,145	inducible nitric oxide synthase	cyclooxygenase-2	4843	5743	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2 , inducible_nitric_oxide_synthase , and hypoxia-inducible_factor_1alpha expression , resulting in reduced angiogenesis .
20546946	0	inducible_nitric_oxide_synthase	76,107	cyclooxygenase-2	109,125	inducible nitric oxide synthase	cyclooxygenase-2	18126(Tax:10090)	19225(Tax:10090)	Gene	Gene	heartwood|nmod|START_ENTITY isolated|nmod|heartwood isolated|xcomp|END_ENTITY	Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible_nitric_oxide_synthase , cyclooxygenase-2 , and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells .
10334391	0	inducible_nitric_oxide_synthase	45,76	iNOS	78,82	inducible nitric oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transcriptional basis for the differences in inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression between nonmetastatic and metastatic murine melanoma cell lines .
10774613	0	inducible_nitric_oxide_synthase	14,45	iNOS	47,51	inducible nitric oxide synthase	iNOS	443078(Tax:9940)	443078(Tax:9940)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- inhibition on smoke inhalation_injury in sheep .
11216878	0	inducible_nitric_oxide_synthase	42,73	iNOS	75,79	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Differential expression and regulation of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA in human trophoblasts in vitro .
11220644	0	inducible_nitric_oxide_synthase	14,45	iNOS	47,51	inducible nitric oxide synthase	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- prevents lung neutrophil deposition and damage in burned rats .
11424980	0	inducible_nitric_oxide_synthase	41,72	iNOS	74,78	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No evidence for involvement of the human inducible_nitric_oxide_synthase -LRB- iNOS -RRB- gene in susceptibility to typical migraine .
12654089	0	inducible_nitric_oxide_synthase	14,45	iNOS	47,51	inducible nitric oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA in target organs of lethal and non-lethal strains of murine malaria .
14516401	0	inducible_nitric_oxide_synthase	19,50	iNOS	52,56	inducible nitric oxide synthase	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in rat with congenital hydronephrosis .
14732335	0	inducible_nitric_oxide_synthase	66,97	iNOS	99,103	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Protein_kinase_C-eta -LRB- PKC-eta -RRB- is required for the development of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- positive phenotype in human monocytic cells .
15086905	0	inducible_nitric_oxide_synthase	43,74	iNOS	76,80	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Advanced_glycosylation end products induce inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via a p38 MAPK-dependent pathway .
15234218	0	inducible_nitric_oxide_synthase	10,41	iNOS	43,47	inducible nitric oxide synthase	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Selective inducible_nitric_oxide_synthase -LRB- iNOS -RRB- inhibition attenuates remote acute_lung_injury in a model of ruptured_abdominal_aortic_aneurysm .
15338679	0	inducible_nitric_oxide_synthase	22,53	iNOS	55,59	inducible nitric oxide synthase	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The potential role of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- activity in the testicular_dysfunction associated with varicocele : an experimental study .
16091294	0	inducible_nitric_oxide_synthase	39,70	iNOS	72,76	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Repression of interferon-gamma-induced inducible_nitric_oxide_synthase -LRB- iNOS -RRB- gene expression in microglia by sodium_butyrate is mediated through specific inhibition of ERK signaling pathways .
16362227	0	inducible_nitric_oxide_synthase	39,70	iNOS	72,76	inducible nitric oxide synthase	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Evaluation of the relationship between inducible_nitric_oxide_synthase -LRB- iNOS -RRB- activity and effects of melatonin in experimental osteoporosis in the rat .
16417967	0	inducible_nitric_oxide_synthase	18,49	iNOS	51,55	inducible nitric oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Manganese induces inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells .
16530791	0	inducible_nitric_oxide_synthase	25,56	iNOS	58,62	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	Tumour overexpression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- increases angiogenesis and may modulate the anti-tumour effects of the vascular disrupting agent ZD6126 .
16584775	0	inducible_nitric_oxide_synthase	91,122	iNOS	124,128	inducible nitric oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Identification of a regulatory cis-element within the 3 ' - untranslated region of the murine inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA ; interaction with heterogeneous nuclear ribonucleoproteins I and L and role in the iNOS gene expression .
19404589	0	inducible_nitric_oxide_synthase	18,49	iNOS	51,55	inducible nitric oxide synthase	iNOS	24599(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- in the testis and epididymis of rats with a dihydrotestosterone -LRB- DHT -RRB- deficiency .
21251970	0	inducible_nitric_oxide_synthase	80,111	iNOS	113,117	inducible nitric oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression in RAW 264.7 cells .
23471078	0	inducible_nitric_oxide_synthase	6,37	iNOS	39,43	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Human inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression depends on chromosome_region_maintenance_1 -LRB- CRM1 -RRB- - and eukaryotic_translation_initiation_factor_4E -LRB- elF4E -RRB- - mediated nucleocytoplasmic mRNA transport .
24858340	0	inducible_nitric_oxide_synthase	13,44	iNOS	46,50	inducible nitric oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression by oxLDL inhibits macrophage derived foam cell migration .
9421860	0	inducible_nitric_oxide_synthase	84,115	iNOS	117,121	inducible nitric oxide synthase	iNOS	18126(Tax:10090)	18126(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Streptococcal pyrogenic exotoxins A -LRB- SpeA -RRB- and C -LRB- SpeC -RRB- stimulate the production of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- protein in RAW 264.7 macrophages .
9625130	0	inducible_nitric_oxide_synthase	14,45	iNOS	47,51	inducible nitric oxide synthase	iNOS	4843	4843	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of inducible_nitric_oxide_synthase -LRB- iNOS -RRB- mRNA in inflamed esophageal and colonic mucosa in a pediatric population .
15350552	0	inducible_nitric_oxide_synthase	30,61	interleukin-1beta	107,124	inducible nitric oxide synthase	interleukin-1beta	24599(Tax:10116)	24494(Tax:10116)	Gene	Gene	START_ENTITY|nmod|hepatocytes hepatocytes|acl|stimulated stimulated|advcl|END_ENTITY	Cycloprodigiosin up-regulates inducible_nitric_oxide_synthase gene expression in hepatocytes stimulated by interleukin-1beta .
21932667	0	inducible_nitric_oxide_synthase	73,104	interleukin-1beta	34,51	inducible nitric oxide synthase	interleukin-1beta	4843	3553	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene END_ENTITY|nmod|expression	-LSB- Effect of lipopolysaccharide and interleukin-1beta on the expression of inducible_nitric_oxide_synthase gene in human periodontal ligament cells -RSB- .
24459328	0	inducible_nitric_oxide_synthase	50,81	interleukin-4	27,40	inducible nitric oxide synthase	interleukin-4	18126(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Anti-inflammatory cytokine interleukin-4 inhibits inducible_nitric_oxide_synthase gene expression in the mouse macrophage cell line RAW264 .7 through the repression of octamer-dependent transcription .
15040111	0	inducible_nitric_oxide_synthase	44,75	nuclear_factor-kappa_B	15,37	inducible nitric oxide synthase	nuclear factor-kappa B	4843	4790	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Expression of nuclear_factor-kappa_B mRNA , inducible_nitric_oxide_synthase and interleukin-6 in nasal polyp and its role -RSB- .
15086905	0	inducible_nitric_oxide_synthase	43,74	p38	99,102	inducible nitric oxide synthase	p38	4843	1432	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Advanced_glycosylation end products induce inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via a p38 MAPK-dependent pathway .
19673942	0	inducible_nitric_oxide_synthase	52,83	renin	127,132	inducible nitric oxide synthase	renin	18126(Tax:10090)	5972	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cellular expression of renal , cardiac and pulmonary inducible_nitric_oxide_synthase in double-transgenic_mice expressing human renin and angiotensinogen genes .
24605775	0	inducible_nitric_oxide_synthase	85,116	testis-specific_high-mobility-group_protein	8,51	inducible nitric oxide synthase	testis-specific high-mobility-group protein	18126(Tax:10090)	21780(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of testis-specific_high-mobility-group_protein in transcriptional regulation of inducible_nitric_oxide_synthase expression in the liver of endotoxic_shock mice .
12397608	0	inducible_nitric_oxide_synthase	145,176	tumor_necrosis_factor-alpha	116,143	inducible nitric oxide synthase	tumor necrosis factor-alpha	4843	7124	Gene	Gene	c-myc|dep|START_ENTITY c-myc|compound|END_ENTITY	Hydrostatic_pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor_necrosis_factor-alpha , inducible_nitric_oxide_synthase , p53 , c-myc , and bax-alpha , and suppression of bcl-2 .
12189113	0	inhibitor-1	67,78	matrix_metalloproteinase-3	11,37	inhibitor-1	matrix metalloproteinase-3	5502	4314	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Myocardial matrix_metalloproteinase-3 and matrix metalloproteinase inhibitor-1 expression in congestive_heart_failure .
15716278	0	inhibitor-1	39,50	transforming_growth_factor-beta	110,141	inhibitor-1	transforming growth factor-beta	5502	7040	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Smad6s regulates plasminogen activator inhibitor-1 through a protein_kinase_C-beta-dependent up-regulation of transforming_growth_factor-beta .
24606484	0	inhibitor_of_DNA_binding_1	32,58	PC3	62,65	inhibitor of DNA binding 1	PC3	3397	5122	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Curcumin inhibits expression of inhibitor_of_DNA_binding_1 in PC3 cells and xenografts .
21478550	0	inhibitor_of_DNA_binding_2	41,67	ID2	69,72	inhibitor of DNA binding 2	ID2	3398	3398	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Large scale RNAi screen reveals that the inhibitor_of_DNA_binding_2 -LRB- ID2 -RRB- protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation .
22172709	0	inhibitor_of_DNA_binding_2	50,76	Id2	78,81	inhibitor of DNA binding 2	Id2	25587(Tax:10116)	25587(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Developmental changes and subcellular location in inhibitor_of_DNA_binding_2 -LRB- Id2 -RRB- immunoreactivity in the rat Corpus callosum .
23743278	0	inhibitor_of_apoptosis_protein	36,66	IAP	68,71	inhibitor of apoptosis protein	IAP	3375	3375	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Design , synthesis and evaluation of inhibitor_of_apoptosis_protein -LRB- IAP -RRB- antagonists that are highly selective for the BIR2 domain of XIAP .
11024045	0	inhibitor_of_apoptosis_protein	15,45	Livin	0,5	inhibitor of apoptosis protein	Livin	84061	79444	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Livin , a novel inhibitor_of_apoptosis_protein family member .
23558671	0	inhibitor_of_differentiation-1	39,69	Id1	71,74	inhibitor of differentiation-1	Id1	15901(Tax:10090)	15901(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Spatial-temporal protein expression of inhibitor_of_differentiation-1 -LRB- Id1 -RRB- during fetal embryogenesis and in different mouse and human cancer types .
18056403	0	inhibitor_of_differentiation_2	14,44	IL-21	0,5	inhibitor of differentiation 2	IL-21	15902(Tax:10090)	60505(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-21 induces inhibitor_of_differentiation_2 and leads to complete abrogation of anaphylaxis in mice .
24115031	0	inhibitor_of_differentiation_3	24,54	interleukin-5	65,78	inhibitor of differentiation 3	interleukin-5	15903(Tax:10090)	16191(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Helix-loop-helix factor inhibitor_of_differentiation_3 regulates interleukin-5 expression and B-1a B cell proliferation .
17763999	0	inhibitor_of_growth_1	23,44	ING1	46,50	inhibitor of growth 1	ING1	3621	3621	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Down-regulation of the inhibitor_of_growth_1 -LRB- ING1 -RRB- tumor suppressor sensitizes p53-deficient glioblastoma cells to cisplatin-induced cell death .
11991811	0	inhibitor_of_growth_1_gene	41,67	ING1	69,73	inhibitor of growth 1 gene	ING1	3621	3621	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Comparative assessment expression of the inhibitor_of_growth_1_gene -LRB- ING1 -RRB- in normal and neoplastic tissues .
19250543	0	inhibitor_of_growth_family_member_4	23,58	ING4	60,64	inhibitor of growth family member 4	ING4	51147	51147	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of the inhibitor_of_growth_family_member_4 -LRB- ING4 -RRB- in different forms of pulmonary_fibrosis .
10738246	0	ink4	12,16	p16	8,11	ink4	p16	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Ectopic p16 -LRB- ink4 -RRB- expression enhances CPT-11-induced apoptosis through increased delay in S-phase progression in human non-small-cell-lung-cancer cells .
11920642	0	ink4a	23,28	p16	19,22	ink4a	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alterations of the p16 -LRB- ink4a -RRB- gene in resected nonsmall_cell_lung_tumors and exfoliated cells within sputum .
17393105	0	ink4a	25,30	p16	21,24	ink4a	p16	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Effects of exogenous p16 -LRB- ink4a -RRB- gene on biological behaviors of human lung_cancer cells .
18418881	0	ink4a	35,40	p16	31,34	ink4a	p16	1029	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Immunocytochemical staining of p16 -LRB- ink4a -RRB- protein as an adjunct test in equivocal liquid-based cytology .
21775818	0	ink4a	19,24	p16	15,18	ink4a	p16	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The meaning of p16 -LRB- ink4a -RRB- expression in tumors : functional significance , clinical associations and future developments .
26794389	0	ink4a	37,42	p53	25,28	ink4a	p53	1029	7157	Gene	Gene	Significance|appos|START_ENTITY Significance|nmod|END_ENTITY	Clinical Significance of p53 and p16 -LRB- ink4a -RRB- Status in a Contemporary North American Penile_Carcinoma Cohort .
11435325	0	ink4b	18,23	p15	14,17	ink4b	p15	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of p15 -LRB- ink4b -RRB- gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors .
15316025	0	inner_centromere_protein	24,48	INCENP	50,56	inner centromere protein	INCENP	3619	3619	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Direct association with inner_centromere_protein -LRB- INCENP -RRB- activates the novel chromosomal passenger protein , Aurora-C .
25586992	0	inner_centromere_protein	26,50	INCENP	52,58	inner centromere protein	INCENP	3619	3619	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Inherited variants in the inner_centromere_protein -LRB- INCENP -RRB- gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast_cancer .
10369859	0	inner_centromere_protein	79,103	Incenp	110,116	inner centromere protein	Incenp	16319(Tax:10090)	16319(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Defective chromosome segregation , microtubule bundling and nuclear bridging in inner_centromere_protein gene -LRB- Incenp -RRB- - disrupted mice .
18094351	0	inner_mitochondrial_membrane_peptidase_2-like	18,63	Immp2l	70,76	inner mitochondrial membrane peptidase 2-like	Immp2l	93757(Tax:10090)	93757(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A mutation in the inner_mitochondrial_membrane_peptidase_2-like gene -LRB- Immp2l -RRB- affects mitochondrial function and impairs fertility in mice .
18223458	0	inosine_triphosphatase	24,46	ITPA	48,52	inosine triphosphatase	ITPA	3704	3704	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the inosine_triphosphatase -LRB- ITPA -RRB- gene : haplotype structure , haplotype-phenotype correlation and promoter function .
3025587	0	inositol-1-phosphate_synthase	43,72	INO1	74,78	inositol-1-phosphate synthase	INO1	853288(Tax:4932)	853288(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the Saccharomyces_cerevisiae inositol-1-phosphate_synthase -LRB- INO1 -RRB- gene is regulated by factors that affect phospholipid synthesis .
12551726	0	inositol_monophosphatase_1	30,56	IMPase_1	58,66	inositol monophosphatase 1	IMPase 1	83523(Tax:10116)	83523(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regional changes in rat brain inositol_monophosphatase_1 -LRB- IMPase_1 -RRB- activity with chronic lithium treatment .
15504365	0	inositol_monophosphatase_2	32,58	IMPA2	60,65	inositol monophosphatase 2	IMPA2	3613	3613	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Lithium modulation of the human inositol_monophosphatase_2 -LRB- IMPA2 -RRB- promoter .
19668216	0	inositol_polyphosphate-5-phosphatase_E	30,68	INPP5E	13,19	inositol polyphosphate-5-phosphatase E	INPP5E	56623	56623	Gene	Gene	Mutations|amod|START_ENTITY Mutations|nmod|END_ENTITY	Mutations in INPP5E , encoding inositol_polyphosphate-5-phosphatase_E , link phosphatidyl_inositol signaling to the ciliopathies .
10780272	0	inositol_polyphosphate_1-phosphatase	51,87	INPP1	94,99	inositol polyphosphate 1-phosphatase	INPP1	3628	3628	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and sequence analysis of a human inositol_polyphosphate_1-phosphatase gene -LRB- INPP1 -RRB- .
21784978	0	inositol_trisphosphate_receptor	110,141	cAMP_response_element_binding_protein	13,50	inositol trisphosphate receptor	cAMP response element binding protein	16438(Tax:10090)	12912(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Constitutive cAMP_response_element_binding_protein -LRB- CREB -RRB- activation by Alzheimer 's _ disease presenilin-driven inositol_trisphosphate_receptor -LRB- InsP3R -RRB- Ca2 + signaling .
18698039	0	inositol_trisphosphate_receptor_type_3	80,118	Bcl-xL	59,65	inositol trisphosphate receptor type 3	Bcl-xL	3710	598	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Gefitinib induction of in vivo detectable signals by Bcl-2 / Bcl-xL modulation of inositol_trisphosphate_receptor_type_3 .
14585928	0	insulin	36,43	ADP-ribosylation_factor_6	0,25	insulin	ADP-ribosylation factor 6	3630	382	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	ADP-ribosylation_factor_6 regulates insulin secretion through plasma membrane phosphatidylinositol_4 ,5 - bisphosphate .
23863634	0	insulin	6,13	AMPK	0,4	insulin	AMPK	3630	5563	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|appos|resistance	AMPK , insulin resistance , and the metabolic_syndrome .
25385647	0	insulin	110,117	ANO1	102,106	insulin	ANO1	3630	55107	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Mapping of long-range INS promoter interactions reveals a role for calcium-activated chloride channel ANO1 in insulin secretion .
12217905	0	insulin	67,74	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	action|compound|START_ENTITY altered|nmod|action altered|nsubjpass|END_ENTITY	Adiponectin is not altered with exercise training despite enhanced insulin action .
14715832	0	insulin	59,66	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY predicts|dobj|resistance predicts|nsubj|END_ENTITY	Adiponectin , an adipocyte-derived protein , predicts future insulin resistance : two-year follow-up study in Japanese population .
15166309	0	insulin	48,55	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	phenotypes|compound|START_ENTITY associated|nmod|phenotypes associated|nsubjpass|END_ENTITY	Adiponectin but not resistin is associated with insulin resistance-related phenotypes in baboons .
15599338	0	insulin	77,84	Adiponectin	1,12	insulin	Adiponectin	3630	9370	Gene	Gene	-RSB-|compound|START_ENTITY development|nmod|-RSB- polymorphism|nmod|development END_ENTITY|dep|polymorphism	-LSB- Adiponectin gene polymorphism and protein dysfunction in the development of insulin resistance -RSB- .
15766512	0	insulin	42,49	Adiponectin	1,12	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|dep|START_ENTITY link|nmod|resistance END_ENTITY|dep|link	-LSB- Adiponectin : a new link between obesity , insulin resistance and cardiovascular_disease -RSB- .
15862282	0	insulin	199,206	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	indices|compound|START_ENTITY independent|nmod|indices correlation|nmod|independent levels|dep|correlation levels|compound|END_ENTITY	Adiponectin and resistin serum levels in women with polycystic_ovary_syndrome during oral glucose tolerance test : a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices .
15886241	0	insulin	21,28	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY predicts|dobj|resistance predicts|nsubj|END_ENTITY	Adiponectin predicts insulin resistance but not endothelial function in young , healthy adolescents .
16236252	0	insulin	53,60	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	independent|nmod|START_ENTITY gluconeogenesis|dobj|independent gluconeogenesis|nsubj|represses represses|compound|END_ENTITY	Adiponectin represses gluconeogenesis independent of insulin in hepatocytes .
16581078	0	insulin	54,61	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY factors|nmod|resistance variants|nmod|factors variants|nsubj|END_ENTITY	Adiponectin and its gene variants as risk factors for insulin resistance , the metabolic_syndrome and cardiovascular_disease .
16755284	0	insulin	13,20	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|appos|resistance	Adiponectin , insulin resistance and clinical expression of the metabolic_syndrome in patients with Type 2 diabetes .
17071536	0	insulin	45,52	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY determinant|nmod|resistance determinant|nsubj|END_ENTITY	Adiponectin is an independent determinant of insulin resistance in women with polycystic_ovary_syndrome .
17216283	0	insulin	63,70	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY syndromes|nmod|resistance screening|nmod|syndromes genes|dep|screening genes|amod|END_ENTITY	Adiponectin receptor genes : mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations .
18535923	0	insulin	44,51	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY biomarker|nmod|resistance END_ENTITY|dep|biomarker	Adiponectin : a biomarker of obesity-induced insulin resistance in adipose tissue and beyond .
18990088	0	insulin	58,65	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY fight|nmod|resistance soul|nmod|fight END_ENTITY|dep|soul	Adiponectin : no longer the lone soul in the fight against insulin resistance ?
19590232	0	insulin	64,71	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY relationship|nmod|resistance END_ENTITY|dep|relationship	Adiponectin in children on peritoneal_dialysis : relationship to insulin resistance and nutritional status .
19886515	0	insulin	14,21	Adiponectin	1,12	insulin	Adiponectin	3630	9370	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|appos|concentrations	-LSB- Adiponectin , insulin and glucose concentrations in overweight and obese subjects after a complex carbohydrates -LRB- fiber -RRB- diet -RSB- .
19906806	0	insulin	15,22	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Adiponectin in insulin resistance : lessons from translational research .
20554486	0	insulin	22,29	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY isoforms|appos|resistance isoforms|compound|END_ENTITY	Adiponectin isoforms , insulin resistance and liver histology in nonalcoholic fatty liver_disease .
21198995	0	insulin	27,34	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	sensitivity|compound|START_ENTITY relation|nmod|sensitivity END_ENTITY|nmod|relation	Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes : a prospective study in 64-year-old women .
21459325	0	insulin	21,28	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	sensitivity|compound|START_ENTITY enhances|dobj|sensitivity enhances|nsubj|END_ENTITY	Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway .
22035239	0	insulin	20,27	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY levels|appos|resistance levels|compound|END_ENTITY	Adiponectin levels , insulin resistance and their relationship with serum levels of inflammatory cytokines in patients with Beh __ et 's _ disease .
24606127	0	insulin	21,28	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	function|compound|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Adiponectin inhibits insulin function in primary trophoblasts by PPARa-mediated ceramide synthesis .
26106273	0	insulin	40,47	Adiponectin	0,11	insulin	Adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY correlate|nmod|resistance correlate|nsubj|levels levels|compound|END_ENTITY	Adiponectin serum levels correlate with insulin resistance in type 2 diabetic patients .
11042022	0	insulin	13,20	Akt	0,3	insulin	Akt	3630	207	Gene	Gene	rescue|compound|START_ENTITY mediates|dobj|rescue mediates|nsubj|END_ENTITY	Akt mediates insulin rescue from apoptosis in brown adipocytes : effect of ceramide .
11788651	0	insulin	19,26	Akt	86,89	insulin	Akt	3630	207	Gene	Gene	resistance|compound|START_ENTITY resistance|dep|activation activation|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Fatty_acid-induced insulin resistance : decreased muscle PI3K activation but unchanged Akt phosphorylation .
15194686	0	insulin	104,111	Akt	52,55	insulin	Akt	3630	207	Gene	Gene	action|nmod|START_ENTITY involved|nmod|action substrate|acl|involved substrate|compound|END_ENTITY	Insulin-response element-binding protein 1 : a novel Akt substrate involved in transcriptional action of insulin .
17028898	0	insulin	12,19	Akt	107,110	insulin	Akt	3630	207	Gene	Gene	defects|compound|START_ENTITY kinase|nsubj|defects kinase|dobj|END_ENTITY	Contrasting insulin dose-dependent defects in activation of atypical protein kinase C and protein_kinase_B / Akt in muscles of obese_diabetic_humans .
17053882	0	insulin	10,17	Akt	35,38	insulin	Akt	3630	207	Gene	Gene	action|compound|START_ENTITY activates|nsubj|action activates|dobj|survival survival|compound|END_ENTITY	Autocrine insulin action activates Akt and increases survival of isolated human islets .
17130464	0	insulin	89,96	Akt	53,56	insulin	Akt	3630	24185(Tax:10116)	Gene	Gene	tissues|compound|START_ENTITY impaired|nmod|tissues impaired|nsubjpass|phosphorylation phosphorylation|nmod|PRAS40 PRAS40|compound|END_ENTITY	Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats .
21558470	0	insulin	112,119	Akt	27,30	insulin	Akt	3630	24185(Tax:10116)	Gene	Gene	and_liver|nmod|START_ENTITY and_liver|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	In situ phosphorylation of Akt and ERK1/2 in rat mammary gland , colon , _ and_liver following treatment with human insulin and IGF-1 .
23092880	0	insulin	27,34	Akt	53,56	insulin	Akt	3630	207	Gene	Gene	secretion|compound|START_ENTITY regulate|dobj|secretion regulate|nmod|END_ENTITY	mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells .
23703573	0	insulin	66,73	B-cell_translocation_gene_2	0,27	insulin	B-cell translocation gene 2	3630	7832	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	B-cell_translocation_gene_2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic b-cells .
6319955	0	insulin	43,50	Beta-endorphin	0,14	insulin	Beta-endorphin	3630	5443	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Beta-endorphin stimulates the secretion of insulin and glucagon_in_diabetes_mellitus .
21628466	0	insulin	38,45	Bone_morphogenetic_protein_3	0,28	insulin	Bone morphogenetic protein 3	3630	110075(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	Bone_morphogenetic_protein_3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes_of_the_young mutation .
18796618	0	insulin	20,27	C-Reactive_protein	0,18	insulin	C-Reactive protein	3630	1401	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|appos|resistance	C-Reactive_protein , insulin resistance , and metabolic_syndrome in a population with a high burden of subclinical_infection : insights from the Genetics of Coronary_Artery_Disease in Alaska Natives -LRB- GOCADAN -RRB- study .
16919544	0	insulin	136,143	C-reactive_protein	31,49	insulin	C-reactive protein	3630	1401	Gene	Gene	resistance|compound|START_ENTITY relation|nmod|resistance END_ENTITY|nmod|relation	Serum levels of interleukin_6 , C-reactive_protein , vascular_cell_adhesion_molecule_1 , and monocyte_chemotactic_protein_1 in relation to insulin resistance and glucose_intolerance -- the Chennai Urban Rural Epidemiology Study -LRB- CURES -RRB- .
17627282	0	insulin	12,19	C/EBPalpha	33,43	insulin	C/EBPalpha	3630	1050	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development .
1862688	0	insulin	25,32	CCK-4	46,51	insulin	CCK-4	3630	5754	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Selective stimulation of insulin secretion by CCK-4 analogues having N-terminal modifications .
2694715	0	insulin	53,60	CCK-4	44,49	insulin	CCK-4	3630	5754	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of some novel synthetic analogues of CCK-4 on insulin and glucagon secretion .
24708911	0	insulin	34,41	CCNG2	0,5	insulin	CCNG2	3630	901	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	CCNG2 and CDK4 is associated with insulin resistance in adipose tissue .
11247544	0	insulin	6,13	CD36	0,4	insulin	CD36	3630	948	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|appos|resistance	CD36 , insulin resistance , and coronary_heart_disease .
26934129	0	insulin	33,40	CD40L	8,13	insulin	CD40L	3630	959	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Soluble CD40L is associated with insulin resistance , but not with glucose tolerance in obese nondiabetic patients .
8976172	0	insulin	8,15	CD8	35,38	insulin	CD8	3630	925	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|compound|END_ENTITY	Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent_diabetes .
24229606	0	insulin	31,38	CIDEC	22,27	insulin	CIDEC	3630	63924	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	-LSB- Research advances on CIDEC in insulin resistance -RSB- .
24760264	0	insulin	39,46	Complement_factor_3	0,19	insulin	Complement factor 3	3630	718	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Complement_factor_3 is associated with insulin resistance and with incident type 2 diabetes over a 7-year follow-up period : the CODAM Study .
17275785	0	insulin	22,29	ERK5	14,18	insulin	ERK5	3630	5598	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells .
10331419	0	insulin	23,30	Endothelin-1	0,12	insulin	Endothelin-1	3630	1906	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells .
9746115	0	insulin	38,45	Endothelin-1	0,12	insulin	Endothelin-1	3630	1906	Gene	Gene	responsiveness|compound|START_ENTITY inhibits|dobj|responsiveness inhibits|nsubj|infusion infusion|amod|END_ENTITY	Endothelin-1 infusion inhibits plasma insulin responsiveness in normal men .
2827626	0	insulin	61,68	Epidermal_growth_factor	0,23	insulin	Epidermal growth factor	3630	1950	Gene	Gene	effect|nmod|START_ENTITY counteracts|dobj|effect counteracts|nsubj|END_ENTITY	Epidermal_growth_factor counteracts the glycogenic effect of insulin in parenchymal hepatocyte cultures .
9759855	0	insulin	104,111	Epidermal_growth_factor	0,23	insulin	Epidermal growth factor	3630	1950	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- modulates fetal thymocyte growth and differentiation : partial reversal by insulin , mimicking by specific inhibitors of EGF receptor tyrosine kinase activity , and differential expression of CD45 phosphatase isotypes .
16405079	0	insulin	34,41	FGF-2	23,28	insulin	FGF-2	3630	2247	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Synergistic effects of FGF-2 with insulin or IGF-I on the proliferation of human auricular chondrocytes .
22223069	0	insulin	21,28	FOXO1	0,5	insulin	FOXO1	3630	56458(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nummod|END_ENTITY	FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes .
25676570	0	insulin	22,29	FOXO1	0,5	insulin	FOXO1	3630	2308	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes .
20060466	0	insulin	35,42	FXR	21,24	insulin	FXR	3630	9971	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	The bile_acid sensor FXR regulates insulin transcription and secretion .
19563779	0	insulin	45,52	FoxO1	30,35	insulin	FoxO1	3630	2308	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Forkhead transcription factor FoxO1 inhibits insulin - and transforming growth factor-beta-stimulated plasminogen_activator_inhibitor-1 expression .
26206703	0	insulin	57,64	FoxO1	9,14	insulin	FoxO1	3630	2308	Gene	Gene	effects|nmod|START_ENTITY integrates|dobj|effects integrates|nsubj|END_ENTITY	Erratum : FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization .
26206703	0	insulin	57,64	FoxO1	9,14	insulin	FoxO1	3630	2308	Gene	Gene	effects|nmod|START_ENTITY integrates|dobj|effects integrates|nsubj|END_ENTITY	Erratum : FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization .
17202144	0	insulin	29,36	Foxo1	107,112	insulin	Foxo1	3630	2308	Gene	Gene	signaling|compound|START_ENTITY activates|nsubj|signaling activates|dobj|androgen androgen|acl|signaling signaling|nmod|interactions interactions|nmod|END_ENTITY	Insulin-like_growth_factor_1 / insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen_receptor .
17627282	0	insulin	12,19	Foxo1	0,5	insulin	Foxo1	3630	2308	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development .
10855533	0	insulin	52,59	GLP-1	26,31	insulin	GLP-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY pulsatile|dobj|secretion pulsatile|nsubj|treatment treatment|nmod|increases increases|compound|END_ENTITY	Short-term treatment with GLP-1 increases pulsatile insulin secretion in Type_II_diabetes with no effect on orderliness .
12475787	0	insulin	67,74	GLP-1	24,29	insulin	GLP-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY process|nmod|secretion actions|nmod|process actions|nmod|END_ENTITY	The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion .
12540611	0	insulin	45,52	GLP-1	17,22	insulin	GLP-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	The influence of GLP-1 on glucose-stimulated insulin secretion : effects on beta-cell sensitivity in type 2 and nondiabetic subjects .
20215429	0	insulin	30,37	GLP-1	21,26	insulin	GLP-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of endogenous GLP-1 on insulin secretion in type 2 diabetes .
21047924	0	insulin	86,93	GLP-1	11,16	insulin	GLP-1	3630	100125288	Gene	Gene	glucagon|compound|START_ENTITY contributions|nmod|glucagon regulates|parataxis|contributions regulates|nsubj|END_ENTITY	Endogenous GLP-1 regulates postprandial glycemia in humans : relative contributions of insulin , glucagon , and gastric emptying .
21645806	0	insulin	40,47	GLP-1	4,9	insulin	GLP-1	493804(Tax:9685)	101097825	Gene	Gene	secretion|compound|START_ENTITY potentiates|dobj|secretion potentiates|nsubj|exenatide exenatide|amod|mimetic mimetic|amod|END_ENTITY	The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats .
22015237	0	insulin	55,62	GLP-1	25,30	insulin	GLP-1	3630	2641	Gene	Gene	analogue|nmod|START_ENTITY analogue|appos|END_ENTITY	Glucagon-like_peptide_1 -LRB- GLP-1 -RRB- analogue combined with insulin reduces HbA1c and weight with low risk of hypoglycemia and high treatment satisfaction .
22421983	0	insulin	51,58	GLP-1	32,37	insulin	GLP-1	3630	100125288	Gene	Gene	patients|compound|START_ENTITY effects|nmod|patients effects|nmod|treatment treatment|compound|END_ENTITY	Metabolic effects of short-term GLP-1 treatment in insulin resistant heart_failure patients .
23573808	0	insulin	70,77	GLP-1	0,5	insulin	GLP-1	3630	2641	Gene	Gene	resistance|compound|START_ENTITY impaired|nmod|resistance impaired|nsubjpass|response response|amod|END_ENTITY	GLP-1 and peptide_YY secretory response after fat load is impaired by insulin resistance , impaired fasting glucose_and_type_2_diabetes in morbidly obese subjects .
23711193	0	insulin	80,87	GLP-1	116,121	insulin	GLP-1	3630	2641	Gene	Gene	using|dobj|START_ENTITY Options|acl|using Options|dep|addition addition|nmod|analogue analogue|compound|END_ENTITY	Options for prandial glucose management in type 2 diabetes patients using basal insulin : addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy .
23997935	0	insulin	70,77	GLP-1	146,151	insulin	GLP-1	3630	2641	Gene	Gene	resistance|compound|START_ENTITY onset|nmod|resistance demonstrate|dobj|onset demonstrate|nmod|mammal mammal|dep|role role|nmod|END_ENTITY	Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal : potential glucogenic role for GLP-1 .
26990378	0	insulin	21,28	GLP-1	185,190	insulin	GLP-1	3630	100125288	Gene	Gene	degludec|compound|START_ENTITY adding|dobj|degludec effect|acl|adding effect|acl|controlled controlled|dobj|trial trial|appos|BEGIN BEGIN|dep|Study Study|compound|END_ENTITY	The effect of adding insulin degludec in patients with type 2 diabetes inadequately controlled with metformin and liraglutide : a double-blind randomized controlled trial -LRB- BEGIN : ADD TO GLP-1 Study -RRB- .
27015674	0	insulin	97,104	GLP-1	37,42	insulin	GLP-1	3630	100125288	Gene	Gene	secretion|compound|START_ENTITY impacts|nmod|secretion impacts|nsubj|Co-culture Co-culture|nmod|cells cells|nmod|line line|compound|END_ENTITY	Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion , proliferation and susceptibility to cytotoxins .
9392481	0	insulin	10,17	GLUT4	21,26	insulin	GLUT4	3630	6517	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique .
12629551	0	insulin	26,33	GPR40	79,84	insulin	GPR40	3630	2864	Gene	Gene	secretion|compound|START_ENTITY regulate|dobj|secretion regulate|nmod|END_ENTITY	Free fatty_acids regulate insulin secretion from pancreatic beta cells through GPR40 .
18583466	0	insulin	80,87	GPR40	33,38	insulin	GPR40	3630	2864	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization .
14534075	0	insulin	84,91	Glucagon-like_peptide-1	0,23	insulin	Glucagon-like peptide-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY associated|nmod|secretion i|acl|associated increase|nmod|i induces|dobj|increase induces|nsubj|END_ENTITY	Glucagon-like_peptide-1 induces a cAMP-dependent increase of -LSB- Na + -RSB- i associated with insulin secretion in pancreatic beta-cells .
16079261	0	insulin	41,48	Glucagon-like_peptide-1	0,23	insulin	Glucagon-like peptide-1	3630	2641	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Glucagon-like_peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site .
24688145	0	insulin	49,56	Glucagon-like_peptide-1	0,23	insulin	Glucagon-like peptide-1	3630	2641	Gene	Gene	glargine|compound|START_ENTITY agonists|nmod|glargine agonists|amod|END_ENTITY	Glucagon-like_peptide-1 receptor agonists versus insulin glargine for type_2_diabetes_mellitus : A systematic review and meta-analysis of randomized controlled trials .
8586147	0	insulin	39,46	Glucagon-like_peptide-1	0,23	insulin	Glucagon-like peptide-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Glucagon-like_peptide-1 and control of insulin secretion .
9338524	0	insulin	78,85	Glucagon-like_peptide-1	0,23	insulin	Glucagon-like peptide-1	3630	2641	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Glucagon-like_peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans .
22253604	0	insulin	69,76	Gpr27	60,65	insulin	Gpr27	3630	2850	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production .
10533850	0	insulin	31,38	Growth_hormone	0,14	insulin	Growth hormone	3630	2688	Gene	Gene	tolerance|compound|START_ENTITY END_ENTITY|nmod|tolerance	Growth_hormone response to the insulin tolerance and clonidine tests in type 1 diabetes .
11883314	0	insulin	17,24	Growth_hormone	1,15	insulin	Growth hormone	3630	2688	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	-LSB- Growth_hormone , insulin , IGF-1 and estradiol levels during maturation of internal sex organs before and at menarche -RSB- .
2036727	0	insulin	46,53	Growth_hormone	0,14	insulin	Growth hormone	3630	2688	Gene	Gene	insulin-like_growth_factor|nmod|START_ENTITY insulin-like_growth_factor|dep|END_ENTITY	Growth_hormone , insulin-like_growth_factor I , insulin and C-peptide during human fetal life : in-utero study .
2202546	0	insulin	16,23	Growth_hormone	0,14	insulin	Growth hormone	105613195	443329(Tax:9940)	Gene	Gene	levels|compound|START_ENTITY lambs|nsubj|levels lambs|advmod|END_ENTITY	Growth_hormone , insulin , prolactin and glucose levels in ewe and ram lambs during normal and compensatory growth .
16516166	0	insulin	65,72	HIF-1alpha	43,53	insulin	HIF-1alpha	3630	3091	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	AMPK activation inhibits the expression of HIF-1alpha induced by insulin and IGF-1 .
2567260	0	insulin	4,11	IDDM	39,43	insulin	IDDM	3630	3630	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	The insulin gene and susceptibility to IDDM .
3525270	0	insulin	31,38	IDDM	54,58	insulin	IDDM	3630	3630	Gene	Gene	requirement|compound|START_ENTITY requirement|nmod|END_ENTITY	The effects of sucrose meal on insulin requirement in IDDM and its modulation by acarbose .
7773292	0	insulin	71,78	IDDM2	55,60	insulin	IDDM2	3630	3630	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription .
14568572	0	insulin	150,157	IGFBP-1	87,94	insulin	IGFBP-1	3630	3484	Gene	Gene	factors|compound|START_ENTITY studies|nmod|factors studies|nmod|regulation regulation|nmod|insulin-like_growth_factor-binding_protein-1 insulin-like_growth_factor-binding_protein-1|appos|END_ENTITY	Comparative studies on the regulation of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- and sex_hormone-binding_globulin -LRB- SHBG -RRB- production by insulin and insulin-like growth factors in human hepatoma cells .
24056811	0	insulin	84,91	IGFBP-1	54,61	insulin	IGFBP-1	3630	3484	Gene	Gene	resistance|compound|START_ENTITY marker|nmod|resistance Delta|dep|marker Delta|appos|END_ENTITY	Delta insulin-like_growth_factor_binding_protein-1 -LRB- / \ IGFBP-1 -RRB- : a marker of hepatic insulin resistance ?
7521354	0	insulin	10,17	IGFBP-1	93,100	insulin	IGFBP-1	3630	3484	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|acl|insulin-like_growth_factor-binding_protein-1 insulin-like_growth_factor-binding_protein-1|dep|END_ENTITY	Effect of insulin on the hepatic production of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- , IGFBP-3 , and IGF-I in insulin-dependent diabetes .
8636256	0	insulin	47,54	IGFBP-1	129,136	insulin	IGFBP-1	3630	3484	Gene	Gene	effect|nmod|START_ENTITY mediates|dobj|effect mediates|nmod|_ _|nmod|production production|appos|END_ENTITY	Insulin_receptor mediates inhibitory effect of insulin , but not of insulin-like_growth_factor _ -LRB- IGF -RRB- - I , on IGF_binding_protein_1 -LRB- IGFBP-1 -RRB- production in human granulosa cells .
26205090	0	insulin	36,43	IL-18	8,13	insulin	IL-18	3630	3606	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|levels levels|compound|END_ENTITY	-LSB- Plasma IL-18 levels are related to insulin and are modulated by IL-18 gene polymorphisms -RSB- .
26205090	0	insulin	36,43	IL-18	8,13	insulin	IL-18	3630	3606	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|levels levels|compound|END_ENTITY	-LSB- Plasma IL-18 levels are related to insulin and are modulated by IL-18 gene polymorphisms -RSB- .
20168253	0	insulin	96,103	IL-6	76,80	insulin	IL-6	3630	3569	Gene	Gene	sensitivity|compound|START_ENTITY END_ENTITY|nmod|sensitivity	Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity .
12054498	0	insulin	38,45	INS-1	59,64	insulin	INS-1	3630	2305	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|lines lines|amod|END_ENTITY	Extracellular acidification parallels insulin secretion in INS-1 and HIT-T15 beta-cell lines .
15650027	0	insulin	34,41	INS-1	68,73	insulin	INS-1	3630	2305	Gene	Gene	activity|compound|START_ENTITY attenuates|dobj|activity attenuates|nmod|beta-cells beta-cells|amod|pancreatic pancreatic|amod|END_ENTITY	Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element .
15756539	0	insulin	53,60	INS-1	95,100	insulin	INS-1	3630	2305	Gene	Gene	secretion|compound|START_ENTITY secretion|acl|signalling signalling|nmod|cells cells|compound|END_ENTITY	Suppression of Pdx-1 perturbs proinsulin processing , insulin secretion and GLP-1 signalling in INS-1 cells .
17686476	0	insulin	40,47	INS-1	80,85	insulin	INS-1	3630	2305	Gene	Gene	marker|nmod|START_ENTITY 3H-serotonin|nmod|marker secretion|nsubj|3H-serotonin secretion|nmod|beta-cells beta-cells|appos|END_ENTITY	3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells -LRB- INS-1 -RRB- .
18082128	0	insulin	33,40	INS-1	109,114	insulin	INS-1	3630	2305	Gene	Gene	secretion|compound|START_ENTITY role|nmod|secretion role|parataxis|alter alter|dobj|composition composition|nmod|cells cells|compound|END_ENTITY	The role of rapid lipogenesis in insulin secretion : Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells .
18562674	0	insulin	59,66	INS-1	80,85	insulin	INS-1	3630	2305	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	CaV1 .2 rather than CaV1 .3 is coupled to glucose-stimulated insulin secretion in INS-1 832/13 cells .
22008547	0	insulin	9,16	INS-1	30,35	insulin	INS-1	3630	2305	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb 's cycle flux independent of ATP synthesis .
26942217	0	insulin	77,84	INS-1	99,104	insulin	INS-1	3630	2305	Gene	Gene	enrichment|nmod|START_ENTITY method|nmod|enrichment granules|nsubj|method granules|nmod|cells cells|compound|END_ENTITY	An efficient two-step subcellular fractionation method for the enrichment of insulin granules from INS-1 cells .
8662272	0	insulin	100,107	INS-1	121,126	insulin	INS-1	3630	2305	Gene	Gene	secretion|compound|START_ENTITY inhibition|nmod|secretion accompanied|nmod|inhibition accompanied|nmod|cells cells|compound|END_ENTITY	Adrenaline - , not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells .
8958215	0	insulin	19,26	INS-1	120,125	insulin	INS-1	3630	2305	Gene	Gene	correlates|compound|START_ENTITY +|nsubj|correlates +|nmod|cells cells|compound|END_ENTITY	Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2 + in aequorin-expressing INS-1 cells .
9482663	0	insulin	52,59	INS-1	41,46	insulin	INS-1	3630	2305	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Glucose rapidly and reversibly decreases INS-1 cell insulin gene transcription via decrements in STF-1 and C1 activator transcription factor activity .
15187412	0	insulin	53,60	IRAP	45,49	insulin	IRAP	3630	4012	Gene	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Role of the insulin-regulated_aminopeptidase IRAP in insulin action and diabetes .
2666067	0	insulin	18,25	IgE	0,3	insulin	IgE	3630	3497	Gene	Gene	peptides|compound|START_ENTITY END_ENTITY|nmod|peptides	IgE antibodies to insulin and related peptides , a result of insulin treatment ?
18412985	0	insulin	76,83	Imp-L2	0,6	insulin	Imp-L2	42549(Tax:7227)	38513(Tax:7227)	Gene	Gene	counteracts|dobj|START_ENTITY counteracts|nsubj|END_ENTITY	Imp-L2 , a putative homolog of vertebrate IGF-binding protein 7 , counteracts insulin signaling in Drosophila and is essential for starvation resistance .
16893359	0	insulin	18,25	Insulin	0,7	insulin	Insulin	3630	3630	Gene	Gene	resistance|compound|START_ENTITY levels|nmod|resistance levels|compound|END_ENTITY	Insulin levels in insulin resistance : phantom of the metabolic opera ?
17429060	0	insulin	47,54	Insulin	96,103	insulin	Insulin	3630	3630	Gene	Gene	START_ENTITY|dep|Resistance Resistance|amod|END_ENTITY	Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort : the Insulin Resistance Atherosclerosis Study .
20425567	0	insulin	9,16	Insulin	0,7	insulin	Insulin	3630	3630	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|appos|resistance	Insulin , insulin resistance , obesity , and cancer .
2055417	0	insulin	62,69	Insulin	0,7	insulin	Insulin	3630	3630	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Insulin and C-peptide levels following oral administration of insulin in intestinal-enzyme protected capsules .
22444446	1	insulin	148,155	Insulin	100,107	insulin	Insulin	3630	3630	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Insulin response with and without a long-acting insulin treatment .
3296383	0	insulin	50,57	Insulin	0,7	insulin	Insulin	3630	3630	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Insulin receptor binding and metabolic effects of insulin in human subcutaneous adipose tissue in untreated non-insulin_dependent_diabetes_mellitus .
3304396	0	insulin	38,45	Insulin	1,8	insulin	Insulin	3630	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	-LSB- Insulin secretion and utilization of insulin in piglets after insulin , arginine and glucose loads -RSB- .
3308560	0	insulin	73,80	Insulin	0,7	insulin	Insulin	3630	3630	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Insulin as a growth regulator of arterial smooth muscle cells : effect of insulin of I.G.F.I. .
8745203	0	insulin	32,39	Insulin	0,7	insulin	Insulin	3630	3630	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Insulin versus a combination of insulin and sulfonylurea in the treatment of NIDDM patients with secondary oral failure .
967015	0	insulin	77,84	Insulin	0,7	insulin	Insulin	3630	3630	Gene	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Insulin sensitivity of adipose tissue in vitro and the response to exogenous insulin in obese human subjects .
7683739	0	insulin	57,64	Insulin-like_growth_factor-binding_protein-1	0,44	insulin	Insulin-like growth factor-binding protein-1	3630	3484	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Insulin-like_growth_factor-binding_protein-1 response to insulin during suppression of endogenous insulin secretion .
17316097	0	insulin	59,66	Insulin-like_growth_factor_binding_protein-1	0,44	insulin	Insulin-like growth factor binding protein-1	3630	3484	Gene	Gene	resistance|compound|START_ENTITY screen|nmod|resistance END_ENTITY|xcomp|screen	Insulin-like_growth_factor_binding_protein-1 to screen for insulin resistance in children .
7523002	0	insulin	63,70	Insulin-like_growth_factor_binding_protein_1	0,44	insulin	Insulin-like growth factor binding protein 1	3630	3484	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Insulin-like_growth_factor_binding_protein_1 response to acute insulin induced hypoglycaemia in type 1 diabetes .
10771998	0	insulin	49,56	Interleukin-1-beta	0,18	insulin	Interleukin-1-beta	3630	3553	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|appos|secretion	Interleukin-1-beta , tumor_necrosis_factor-alpha , insulin secretion and oral glucose tolerance in non-diabetic siblings of children with IDDM .
10856890	0	insulin	24,31	Interleukin-6	0,13	insulin	Interleukin-6	3630	3569	Gene	Gene	secretion|compound|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	Interleukin-6 increases insulin secretion and preproinsulin mRNA expression via Ca2 + - dependent mechanism .
2404746	0	insulin	22,29	Interleukin-6	0,13	insulin	Interleukin-6	3630	24498(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY affects|dobj|secretion affects|nsubj|END_ENTITY	Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro .
14998783	0	insulin	90,97	LDL_receptor	69,81	insulin	LDL receptor	397415(Tax:9823)	396801(Tax:9823)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL_receptor gene by insulin and LH in cultured porcine granulosa-luteal cells .
24247826	0	insulin	29,36	LIM_kinase_1	0,12	insulin	LIM kinase 1	3630	3984	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	LIM_kinase_1 is required for insulin - dependent cell growth of osteosarcoma cell lines .
10323373	0	insulin	24,31	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Leptin before and after insulin therapy in children with new-onset type 1 diabetes .
10523021	0	insulin	19,26	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Leptin response to insulin in humans is related to the lipolytic state of abdominal subcutaneous fat .
10690955	0	insulin	80,87	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	sensitivity|compound|START_ENTITY serum|dobj|sensitivity relation|acl|serum END_ENTITY|dep|relation	Leptin during and after preeclamptic or normal pregnancy : its relation to serum insulin and insulin sensitivity .
12369715	0	insulin	67,74	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	therapy|compound|START_ENTITY effect|nmod|therapy END_ENTITY|dep|effect	Leptin in children with newly diagnosed type 1 diabetes : effect of insulin therapy .
17441374	0	insulin	74,81	Leptin	1,7	insulin	Leptin	3630	3952	Gene	Gene	tissue|nmod|START_ENTITY distribution|nmod|tissue correlates|nmod|distribution correlates|nsubj|END_ENTITY	-LSB- Leptin correlates with distribution of fatty tissue and plasma levels of insulin , testosterone and tumor_necrosis_factor_alpha in perimenopausal women with increased testosterone level and central location of body fat -RSB- .
18370722	0	insulin	26,33	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Leptin is associated with insulin resistance in Japanese migrants .
19115596	0	insulin	9,16	Leptin	1,7	insulin	Leptin	3630	3952	Gene	Gene	mass|compound|START_ENTITY END_ENTITY|appos|mass	-LSB- Leptin , insulin , IGF-1 and bone mass in a group of sedentary adolescent girls -RSB- .
19995720	0	insulin	116,123	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	index|compound|START_ENTITY concentrations|advcl|index concentrations|nsubj|END_ENTITY	Leptin concentrations in patients with polycystic_ovary_syndrome before and after met-formin treatment depending on insulin resistance , body mass index and androgen con-centrations -- introductory report .
22759970	0	insulin	15,22	Leptin	0,6	insulin	Leptin	3630	16846(Tax:10090)	Gene	Gene	action|compound|START_ENTITY affects|dobj|action affects|nsubj|END_ENTITY	Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity .
8801538	0	insulin	61,68	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	independent|nmod|START_ENTITY enters|nmod|independent enters|nsubj|END_ENTITY	Leptin enters the brain by a saturable system independent of insulin .
9024222	0	insulin	50,57	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	effects|nmod|START_ENTITY resistant|nmod|effects resistant|nsubj|synthesis synthesis|compound|END_ENTITY	Leptin synthesis is resistant to acute effects of insulin in insulin-dependent diabetes_mellitus patients .
9451467	0	insulin	21,28	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Leptin inhibition of insulin secretion from isolated human islets .
9725819	0	insulin	84,91	Leptin	0,6	insulin	Leptin	3630	3952	Gene	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|compound|END_ENTITY	Leptin expression in adipose tissue from obese humans : depot-specific regulation by insulin and dexamethasone .
19460352	0	insulin	21,28	MED23	9,14	insulin	MED23	3630	9439	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Mediator MED23 links insulin signaling to the adipogenesis transcription cascade .
23217386	0	insulin	44,51	MEK1	0,4	insulin	MEK1	3630	5604	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	MEK1 and MEK2 differentially regulate human insulin - _ and_insulin glargine-induced human bladder_cancer T24 cell proliferation .
12011435	0	insulin	37,44	MafA	92,96	insulin	MafA	3630	389692	Gene	Gene	gene|compound|START_ENTITY Identification|nmod|gene transcription|nsubj|Identification transcription|nmod|END_ENTITY	Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA .
12368292	0	insulin	96,103	MafA	0,4	insulin	MafA	3630	389692	Gene	Gene	gene|compound|START_ENTITY activator|nmod|gene activator|nsubj|END_ENTITY	MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene .
14973194	0	insulin	90,97	MafA	4,8	insulin	MafA	3630	389692	Gene	Gene	expression|nmod|START_ENTITY responsible|nmod|expression appears|xcomp|responsible appears|nsubj|factor factor|compound|END_ENTITY	The MafA transcription factor appears to be responsible for tissue-specific expression of insulin .
15664999	0	insulin	106,113	MafA	54,58	insulin	MafA	3630	389692	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression mechanism|nmod|loss Oxidative|nmod|mechanism Oxidative|dobj|loss loss|nmod|protein protein|compound|END_ENTITY	Oxidative stress-mediated , post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells .
15993959	0	insulin	30,37	MafA	100,104	insulin	MafA	3630	389692	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter enriched|nsubj|activation enriched|xcomp|END_ENTITY	Synergistic activation of the insulin gene promoter by the beta-cell enriched transcription factors MafA , Beta2 , and Pdx1 .
18515495	0	insulin	37,44	MafA	0,4	insulin	MafA	396145(Tax:9031)	395881(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY activator|nmod|gene activator|nsubj|END_ENTITY	MafA is a dedicated activator of the insulin gene in vivo .
20682694	0	insulin	64,71	MafA	23,27	insulin	MafA	3630	389692	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes .
21857924	0	insulin	82,89	MafA	29,33	insulin	MafA	3630	389692	Gene	Gene	expression|compound|START_ENTITY results|nmod|expression transduction|nmod|results transduction|nmod|protein protein|compound|END_ENTITY	TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphology .
9458777	0	insulin	35,42	Motilin	0,7	insulin	Motilin	483665(Tax:9615)	481748(Tax:9615)	Gene	Gene	release|nmod|START_ENTITY controls|dobj|release controls|nsubj|END_ENTITY	Motilin controls cyclic release of insulin through vagal cholinergic muscarinic pathways in fasted dogs .
20682839	0	insulin	124,131	NTPDase3	112,120	insulin	NTPDase3	3630	956	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Identification of the ectonucleotidases expressed in mouse , rat , and human Langerhans islets : potential role of NTPDase3 in insulin secretion .
22160469	0	insulin	18,25	NYGGF4	8,14	insulin	NYGGF4	3630	55022	Gene	Gene	resistance|compound|START_ENTITY Role|nmod|resistance Role|nmod|END_ENTITY	Role of NYGGF4 in insulin resistance .
7007696	0	insulin	37,44	Na-K	48,52	insulin	Na-K	3630	29110	Gene	Gene	START_ENTITY|nmod|system system|compound|END_ENTITY	Apparent affinity changes induced by insulin of Na-K transport system in frog skeletal muscle .
18288188	0	insulin	58,65	O-GlcNAc_transferase	34,54	insulin	O-GlcNAc transferase	3630	8473	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Phosphoinositide signalling links O-GlcNAc_transferase to insulin resistance .
25324439	0	insulin	89,96	Omentin	0,7	insulin	Omentin	3630	55600	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Omentin , an adipokine with insulin-sensitizing properties , is negatively associated with insulin resistance in normal gestation .
26034511	0	insulin	31,38	Osteoprotegerin	0,15	insulin	Osteoprotegerin	3630	4982	Gene	Gene	resistance|compound|START_ENTITY relation|nmod|resistance END_ENTITY|nmod|relation	Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal_obesity .
11162462	0	insulin	70,77	PAI-1	11,16	insulin	PAI-1	3630	5054	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Release of PAI-1 by human preadipocytes and adipocytes independent of insulin and IGF-1 .
10390156	0	insulin	18,25	PDX-1	92,97	insulin	PDX-1	3630	3651	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|dep|stimulation stimulation|nmod|potency potency|nmod|domain domain|compound|END_ENTITY	Regulation of the insulin gene by glucose : stimulation of trans-activation potency of human PDX-1 N-terminal domain .
10426567	0	insulin	101,108	PDX-1	209,214	insulin	PDX-1	3630	3651	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene protein_kinase_C|nmod|expression involvement|nmod|protein_kinase_C involvement|appos|END_ENTITY	Possible involvement of atypical protein_kinase_C -LRB- PKC -RRB- in glucose-sensitive expression of the human insulin gene : DNA-binding activity and transcriptional activity of pancreatic_and_duodenal_homeobox_gene-1 -LRB- PDX-1 -RRB- are enhanced via calphostin_C-sensitive but phorbol_12-myristate_13-acetate -LRB- PMA -RRB- and G 6976-insensitive pathway .
10868963	0	insulin	22,29	PDX-1	79,84	insulin	PDX-1	3630	3651	Gene	Gene	levels|compound|START_ENTITY modulation|nmod|levels dependent|nsubj|modulation dependent|nmod|END_ENTITY	Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2 + .
15028719	0	insulin	58,65	PDX-1	26,31	insulin	PDX-1	3630	3651	Gene	Gene	enhancer|compound|START_ENTITY Identification|nmod|enhancer Identification|nmod|site site|compound|END_ENTITY	Identification of a novel PDX-1 binding site in the human insulin gene enhancer .
15793239	0	insulin	74,81	PDX-1	0,5	insulin	PDX-1	3630	3651	Gene	Gene	transcription|compound|START_ENTITY induces|dobj|transcription END_ENTITY|appos|induces	PDX-1 / VP16 fusion protein , together with NeuroD or Ngn3 , markedly induces insulin gene transcription and ameliorates glucose tolerance .
15862113	0	insulin	82,89	PDX-1	25,30	insulin	PDX-1	3630	3651	Gene	Gene	promoter|compound|START_ENTITY regulation|nmod|promoter contribution|nmod|regulation contribution|nmod|END_ENTITY	Relative contribution of PDX-1 , MafA and E47/beta2 to the regulation of the human insulin promoter .
16461554	0	insulin	44,51	PDX-1	15,20	insulin	PDX-1	3630	3651	Gene	Gene	transcription|compound|START_ENTITY Involvement|nmod|transcription Involvement|nmod|END_ENTITY	Involvement of PDX-1 in activation of human insulin gene transcription .
22790351	0	insulin	24,31	PDX-1	92,97	insulin	PDX-1	3630	3651	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver_cirrhosis : a comparative investigation using human autopsy specimens .
23703573	0	insulin	66,73	PDX-1	101,106	insulin	PDX-1	3630	3651	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|induction induction|nmod|END_ENTITY	B-cell_translocation_gene_2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic b-cells .
8922372	0	insulin	14,21	PDX-1	0,5	insulin	PDX-1	3630	3651	Gene	Gene	expressions|compound|START_ENTITY induces|dobj|expressions induces|nsubj|END_ENTITY	PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin .
9312185	0	insulin	81,88	PDX-1	36,41	insulin	PDX-1	3630	3651	Gene	Gene	mRNA|compound|START_ENTITY decrease|nmod|mRNA causes|dobj|decrease -1|parataxis|causes -1|dep|Suppression Suppression|nmod|END_ENTITY	Suppression of transcription factor PDX-1 / IPF1/STF -1 / IDX-1 causes no decrease in insulin mRNA in MIN6 cells .
22390153	0	insulin	83,90	PKCZ	22,26	insulin	PKCZ	3630	5590	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|nmod|END_ENTITY	Protein expression of PKCZ -LRB- Protein_Kinase_C_Zeta -RRB- , Munc18c , and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic_ovary_syndrome -LRB- PCOS -RRB- .
12107244	0	insulin	50,57	PTH	35,38	insulin	PTH	3630	5741	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Acute changes of bone turnover and PTH induced by insulin and glucose : euglycemic and hypoglycemic_hyperinsulinemic_clamp_studies .
2134219	0	insulin	23,30	Pancreastatin	0,13	insulin	Pancreastatin	397415(Tax:9823)	397540(Tax:9823)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Pancreastatin inhibits insulin secretion and exocrine pancreatic secretion in the pig .
20428418	0	insulin	14,21	Part_1	37,43	insulin	Part 1	3630	25859	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of insulin on the heart : Part_1 : Effects on metabolism and function .
15144884	0	insulin	14,21	Pdx-1	0,5	insulin	Pdx-1	3630	3651	Gene	Gene	secretion|compound|START_ENTITY enables|dobj|secretion enables|nsubj|END_ENTITY	Pdx-1 enables insulin secretion by regulating synaptotagmin_1 gene expression .
15166251	0	insulin	22,29	Pdx-1	126,131	insulin	Pdx-1	3630	3651	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression requires|nsubj|regulation requires|nmod|END_ENTITY	Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1 .
15743769	0	insulin	13,20	Pdx-1	76,81	insulin	Pdx-1	3630	3651	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1 : application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes .
15756539	0	insulin	53,60	Pdx-1	15,20	insulin	Pdx-1	3630	3651	Gene	Gene	secretion|compound|START_ENTITY processing|appos|secretion perturbs|dobj|processing perturbs|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of Pdx-1 perturbs proinsulin processing , insulin secretion and GLP-1 signalling in INS-1 cells .
16141209	0	insulin	94,101	Pdx-1	0,5	insulin	Pdx-1	3630	3651	Gene	Gene	transcription|compound|START_ENTITY activation|nmod|transcription elongation|nmod|activation II|acl|elongation histone|nmod|II histone|nsubj|links links|amod|END_ENTITY	Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription .
17451835	0	insulin	66,73	Pdx-1	5,10	insulin	Pdx-1	3630	3651	Gene	Gene	expression|compound|START_ENTITY maintenance|nmod|expression requisite|nmod|maintenance requisite|nsubj|END_ENTITY	Both Pdx-1 and NeuroD1 genes are requisite for the maintenance of insulin gene expression in ES-derived differentiated cells .
2115686	1	insulin	158,165	Pen	196,199	insulin	Pen	3630	340348	Gene	Gene	administration|compound|START_ENTITY administration|acl|using using|dobj|-RSB- -RSB-|compound|END_ENTITY	Randomized study between evening and morning intermediary insulin administration using the Novo Pen semi-automatic insulin injector -RSB- .
2115686	1	insulin	215,222	Pen	196,199	insulin	Pen	3630	340348	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Randomized study between evening and morning intermediary insulin administration using the Novo Pen semi-automatic insulin injector -RSB- .
8616536	0	insulin	47,54	Peptide_YY	0,10	insulin	Peptide YY	3630	5697	Gene	Gene	secretion|compound|START_ENTITY inhibit|dobj|secretion inhibit|nsubj|END_ENTITY	Peptide_YY does not inhibit glucose-stimulated insulin secretion in humans .
1563535	0	insulin	64,71	Plasminogen_activator_inhibitor_1	0,33	insulin	Plasminogen activator inhibitor 1	3630	5054	Gene	Gene	resistance|compound|START_ENTITY levels|nmod|resistance levels|compound|END_ENTITY	Plasminogen_activator_inhibitor_1 and insulin levels in various insulin resistance states .
10710511	0	insulin	27,34	Protein_kinase_C	0,16	insulin	Protein kinase C	3630	112476	Gene	Gene	action|compound|START_ENTITY modulates|dobj|action modulates|nsubj|END_ENTITY	Protein_kinase_C modulates insulin action in human skeletal muscle .
23204109	0	insulin	55,62	Protein_kinase_C-b	0,18	insulin	Protein kinase C-b	3630	5579	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Protein_kinase_C-b contributes to impaired endothelial insulin signaling in humans with diabetes_mellitus .
7951555	0	insulin	74,81	Pst	43,46	insulin	Pst	3630	7903	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	Hind III site causing Proinsulin Kyoto and Pst I site polymorphism of the insulin gene in Japanese : its lack of association with either IDDM or NIDDM .
24994759	0	insulin	33,40	RBP4	23,27	insulin	RBP4	3630	5950	Gene	Gene	resistance|compound|START_ENTITY Association|nmod|resistance Association|nmod|END_ENTITY	Association of urinary RBP4 with insulin resistance , inflammation , and microalbuminuria .
23272222	0	insulin	84,91	REDD1	54,59	insulin	REDD1	3630	54541	Gene	Gene	contributes|nmod|START_ENTITY contributes|dep|Regulated Regulated|dobj|-1 -1|appos|END_ENTITY	Regulated in development and DNA damage responses -1 -LRB- REDD1 -RRB- protein contributes to insulin signaling pathway in adipocytes .
11786595	0	insulin	63,70	Resistin	0,8	insulin	Resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY related|nmod|resistance related|nsubjpass|expression expression|compound|END_ENTITY	Resistin gene expression in human adipocytes is not related to insulin resistance .
14671216	0	insulin	67,74	Resistin	0,8	insulin	Resistin	3630	56729	Gene	Gene	expression|nmod|START_ENTITY regulation|nmod|expression END_ENTITY|dep|regulation	Resistin and type 2 diabetes : regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes .
22934726	0	insulin	101,108	Resistin	0,8	insulin	Resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY expression|nmod|resistance expression|compound|END_ENTITY	Resistin gene expression in visceral adipose tissue of postmenopausal women and its association with insulin resistance .
17299074	0	insulin	45,52	Retinol-binding_protein_4	0,25	insulin	Retinol-binding protein 4	3630	5950	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Retinol-binding_protein_4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes .
18362299	0	insulin	45,52	Retinol-binding_protein_4	0,25	insulin	Retinol-binding protein 4	3630	5950	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Retinol-binding_protein_4 is associated with insulin resistance , but appears unsuited for metabolic screening in women with polycystic_ovary_syndrome .
21741059	0	insulin	49,56	Retinol-binding_protein_4	0,25	insulin	Retinol-binding protein 4	3630	5950	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Retinol-binding_protein_4 is not associated with insulin resistance in pregnancy .
24645678	0	insulin	26,33	SH2B1	0,5	insulin	SH2B1	3630	20399(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	SH2B1 in b-cells promotes insulin expression and glucose metabolism in mice .
24576898	0	insulin	15,22	SIK2	0,4	insulin	SIK2	3630	23235	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	SIK2 regulates insulin secretion .
20960276	0	insulin	53,60	SIRT1	83,88	insulin	SIRT1	3630	23411	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells .
20683642	0	insulin	15,22	SOCS3	0,5	insulin	SOCS3	3630	9021	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	SOCS3 inhibits insulin signaling in porcine primary adipocytes .
24711032	0	insulin	46,53	SOCS3	16,21	insulin	SOCS3	3630	9021	Gene	Gene	resistance|compound|START_ENTITY polymorphisms|nmod|resistance polymorphisms|nsubj|Association Association|nmod|gene gene|compound|END_ENTITY	-LSB- Association of SOCS3 gene polymorphisms with insulin resistance in Xinjiang Uygur population -RSB- .
25938827	0	insulin	103,110	SOCS3	49,54	insulin	SOCS3	3630	9021	Gene	Gene	resistance|compound|START_ENTITY occurrence|nmod|resistance underlying|nmod|occurrence underlying|dobj|effect effect|nmod|polymorphism polymorphism|nummod|END_ENTITY	-LSB- Study of the mechanism underlying the effect of SOCS3 rs4969170 A/G polymorphism on the occurrence of insulin resistance in chronic hepatitis_C patients -RSB- .
21293887	0	insulin	67,74	STAT3	44,49	insulin	STAT3	3630	6774	Gene	Gene	resistance|compound|START_ENTITY effect|nmod|resistance has|dobj|effect has|nsubj|induction induction|nmod|expression expression|nmod|END_ENTITY	IL-6 induction of TLR-4 gene expression via STAT3 has an effect on insulin resistance in human skeletal muscle .
26266089	0	insulin	76,83	STAT3	12,17	insulin	STAT3	483665(Tax:9615)	20848(Tax:10090)	Gene	Gene	resistance|compound|START_ENTITY prevent|dobj|resistance prevent|nsubj|Knockout Knockout|nmod|END_ENTITY	Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance .
18684447	0	insulin	10,17	SULT2A1	79,86	insulin	SULT2A1	3630	6822	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin and testosterone on androgen production and transcription of SULT2A1 in the NCI-H295R adrenocortical cell line .
10617282	0	insulin	107,114	Shc	149,152	insulin	Shc	3630	6464	Gene	Gene	receptors|compound|START_ENTITY leading|nmod|receptors pathways|acl|leading regulates|nsubj|pathways regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Intracellular signalling pathways of okadaic_acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors : okadaic_acid regulates Shc phosphorylation by mechanisms independent of insulin .
10617282	0	insulin	198,205	Shc	149,152	insulin	Shc	3630	6464	Gene	Gene	mechanisms|nmod|START_ENTITY regulates|nmod|mechanisms regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Intracellular signalling pathways of okadaic_acid leading to mitogenesis in Rat1 fibroblast overexpressing insulin receptors : okadaic_acid regulates Shc phosphorylation by mechanisms independent of insulin .
11788655	0	insulin	133,140	Shc	110,113	insulin	Shc	3630	6464	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Down-regulation of insulin_receptor_substrates _ -LRB- IRS -RRB- -1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes .
8621421	0	insulin	129,136	Shc	50,53	insulin	Shc	3630	6464	Gene	Gene	receptors|nmod|START_ENTITY domains|nmod|receptors domains|nsubj|mapping mapping|nmod|sites sites|nmod|SH2 SH2|compound|END_ENTITY	Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin_receptor_substrate-1 and the receptors for insulin , epidermal growth factor , platelet-derived growth factor , and fibroblast growth factor .
8702728	0	insulin	75,82	Shc	50,53	insulin	Shc	3630	6464	Gene	Gene	receptors|compound|START_ENTITY interaction|nmod|receptors importance|nmod|interaction importance|nmod|domain domain|nmod|END_ENTITY	Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner .
10830280	0	insulin	22,29	Stat_5B	0,7	insulin	Stat 5B	3630	6777	Gene	Gene	activated|nmod|START_ENTITY END_ENTITY|acl|activated	Stat_5B , activated by insulin in a Jak-independent fashion , plays a role in glucokinase gene transcription .
24560937	0	insulin	105,112	TADG-12	0,7	insulin	TADG-12	3630	64699	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	TADG-12 as an early marker in the development of pancreatic_ductal_adenocarcinoma -LRB- PDAC -RRB- : involvement of insulin containing cells .
18481957	0	insulin	16,23	TCF7L2	0,6	insulin	TCF7L2	3630	6934	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells .
19325541	0	insulin	51,58	TFAP2B	25,31	insulin	TFAP2B	3630	7021	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents .
22382194	0	insulin	26,33	TNF-a	15,20	insulin	TNF-a	3630	7124	Gene	Gene	resistance|compound|START_ENTITY Association|nmod|resistance Association|nmod|END_ENTITY	Association of TNF-a with insulin resistance in type_2_diabetes_mellitus .
15146098	0	insulin	25,32	TNF-alpha	12,21	insulin	TNF-alpha	3630	7124	Gene	Gene	resistance|compound|START_ENTITY role|nmod|resistance role|nmod|END_ENTITY	The role of TNF-alpha in insulin resistance .
19254569	0	insulin	24,31	TORC2	0,5	insulin	TORC2	3630	200186	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic_acid phosphatase , LIPIN1 .
16806463	0	insulin	15,22	TRPM4	0,5	insulin	TRPM4	3630	54795	Gene	Gene	secretion|compound|START_ENTITY controls|dobj|secretion controls|nsubj|END_ENTITY	TRPM4 controls insulin secretion in pancreatic beta-cells .
9081122	0	insulin	71,78	Transforming_growth_factor_beta_1	0,33	insulin	Transforming growth factor beta 1	3630	7040	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 inhibits the proliferative effect of insulin on human infragenicular vascular smooth muscle cells .
10419100	0	insulin	45,52	Tumor_necrosis_factor-alpha	0,27	insulin	Tumor necrosis factor-alpha	3630	7124	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Tumor_necrosis_factor-alpha and ceramides in insulin resistance .
12716765	0	insulin	78,85	UCP2	41,45	insulin	UCP2	3630	7351	Gene	Gene	secretion|compound|START_ENTITY variation|nmod|secretion contributes|nmod|variation contributes|nsubj|polymorphism polymorphism|nmod|promoter promoter|nmod|END_ENTITY	A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects .
19065272	0	insulin	80,87	UCP2	13,17	insulin	UCP2	3630	7351	Gene	Gene	secretion|compound|START_ENTITY regulation|nmod|secretion role|nmod|regulation reveal|dobj|role reveal|nsubj|Mutations Mutations|nmod|END_ENTITY	Mutations in UCP2 in congenital_hyperinsulinism reveal a role for regulation of insulin secretion .
22349573	0	insulin	56,63	UCP2	13,17	insulin	UCP2	3630	7351	Gene	Gene	resistance|compound|START_ENTITY protects|nmod|resistance >|acl:relcl|protects >|compound|END_ENTITY	The frequent UCP2 -866 G > A polymorphism protects against insulin resistance and is associated with obesity : a study of obesity and related metabolic traits among 17 636 Danes .
20031629	0	insulin	28,35	USF1	49,53	insulin	USF1	3630	7391	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Functional variant disrupts insulin induction of USF1 : mechanism for USF1-associated dyslipidemias .
17360501	0	insulin	41,48	Urocortin_3	0,11	insulin	Urocortin 3	3630	83428(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Urocortin_3 regulates glucose-stimulated insulin secretion and energy homeostasis .
19040082	0	insulin	11,18	VEGF	22,26	insulin	VEGF	280829(Tax:9913)	281572(Tax:9913)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of insulin on VEGF expression in bovine retinal microvascular endothelial cells exposed to normal or high glucose -RSB- .
23275352	0	insulin	40,47	Zinc-a2-glycoprotein	0,20	insulin	Zinc-a2-glycoprotein	3630	563	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Zinc-a2-glycoprotein is associated with insulin resistance in humans and is regulated by hyperglycemia , hyperinsulinemia , or liraglutide administration : cross-sectional and interventional studies in normal subjects , insulin-resistant subjects , and subjects with newly diagnosed diabetes .
16984975	0	insulin	99,106	ZnT8	75,79	insulin	ZnT8	3630	169026	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion .
12827242	0	insulin	75,82	adiponectin	21,32	insulin	adiponectin	3630	9370	Gene	Gene	sensitivity|compound|START_ENTITY modulation|nmod|sensitivity genotypes|nmod|modulation genotypes|nsubj|epistasis epistasis|nmod|END_ENTITY	Genetic epistasis of adiponectin and PPARgamma2 genotypes in modulation of insulin sensitivity : a family-based association study .
15579191	0	insulin	39,46	adiponectin	16,27	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY Correlations|nmod|resistance Correlations|nmod|level level|compound|END_ENTITY	Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations .
15698395	0	insulin	98,105	adiponectin	16,27	insulin	adiponectin	3630	9370	Gene	Gene	levels|compound|START_ENTITY correlate|nmod|levels correlate|nsubj|concentrations concentrations|compound|END_ENTITY	Elevated plasma adiponectin concentrations in patients with liver_cirrhosis correlate with plasma insulin levels .
15734858	0	insulin	83,90	adiponectin	70,81	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|appos|resistance	Adipocytokines and VLDL metabolism : independent regulatory effects of adiponectin , insulin resistance , and fat compartments on VLDL apolipoprotein_B-100 kinetics ?
15824752	0	insulin	48,55	adiponectin	81,92	insulin	adiponectin	3630	9370	Gene	Gene	sensitivity|compound|START_ENTITY marker|nmod|sensitivity mass|nmod|marker mass|dep|role role|nmod|END_ENTITY	Lower-body fat mass as an independent marker of insulin sensitivity -- the role of adiponectin .
15862282	0	insulin	199,206	adiponectin	159,170	insulin	adiponectin	3630	9370	Gene	Gene	indices|compound|START_ENTITY independent|nmod|indices independent|compound|END_ENTITY	Adiponectin and resistin serum levels in women with polycystic_ovary_syndrome during oral glucose tolerance test : a significant reciprocal correlation between adiponectin and resistin independent of insulin resistance indices .
16285470	0	insulin	60,67	adiponectin	34,45	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY background|nmod|resistance background|nmod|END_ENTITY	Biological background and role of adiponectin as marker for insulin resistance and cardiovascular risk .
16498821	0	insulin	44,51	adiponectin	13,24	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY pathogenesis|nmod|resistance END_ENTITY|nmod|pathogenesis	-LSB- The role of adiponectin in pathogenesis of insulin resistance and metabolic_syndrome -RSB- .
16571847	0	insulin	33,40	adiponectin	16,27	insulin	adiponectin	3630	9370	Gene	Gene	sensitivity|compound|START_ENTITY Relationship|nmod|sensitivity Relationship|nmod|END_ENTITY	Relationship of adiponectin with insulin sensitivity in humans , independent of lipid availability .
16624648	0	insulin	43,50	adiponectin	52,63	insulin	adiponectin	3630	9370	Gene	Gene	and_insulin-like_growth_factor-I|compound|START_ENTITY and_insulin-like_growth_factor-I|dep|END_ENTITY	Body fat at birth and cord blood levels of insulin , adiponectin , leptin , _ and_insulin-like_growth_factor-I in small-for-gestational-age infants .
16814726	0	insulin	56,63	adiponectin	34,45	insulin	adiponectin	3630	9370	Gene	Gene	action|compound|START_ENTITY modulates|dobj|action modulates|nsubj|END_ENTITY	APPLied mechanics : uncovering how adiponectin modulates insulin action .
17038635	0	insulin	87,94	adiponectin	7,18	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY levels|nmod|resistance levels|compound|END_ENTITY	Plasma adiponectin levels in relation to carotid intima_media_thickness and markers of insulin resistance .
17264850	0	insulin	133,140	adiponectin	16,27	insulin	adiponectin	3630	9370	Gene	Gene	reveal|nmod|START_ENTITY reveal|nsubj|Associations Associations|nmod|END_ENTITY	Associations of adiponectin with metabolic and vascular risk parameters in the British Regional Heart Study reveal stronger links to insulin resistance-related than to coronory heart_disease risk-related parameters .
17303804	0	insulin	37,44	adiponectin	22,33	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY influences|nmod|resistance influences|nmod|END_ENTITY	Genetic influences of adiponectin on insulin resistance , type 2 diabetes , and cardiovascular_disease .
17322583	0	insulin	30,37	adiponectin	9,20	insulin	adiponectin	3630	9370	Gene	Gene	secretion|compound|START_ENTITY augments|dobj|secretion augments|nsubj|END_ENTITY	Globular adiponectin augments insulin secretion from pancreatic islet beta cells at high glucose concentrations .
18208577	0	insulin	81,88	adiponectin	38,49	insulin	adiponectin	3630	9370	Gene	Gene	status|compound|START_ENTITY regulated|nmod|status regulated|nsubjpass|effect effect|nmod|expression expression|compound|END_ENTITY	Insulin effect on adipose_tissue -LRB- AT -RRB- adiponectin expression is regulated by the insulin resistance status of the patients .
18401239	0	insulin	38,45	adiponectin	11,22	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY concentration|appos|resistance concentration|compound|END_ENTITY	Postpartum adiponectin concentration , insulin resistance and metabolic_abnormalities among women with pregnancy-induced disturbances .
18440519	0	insulin	130,137	adiponectin	83,94	insulin	adiponectin	3630	9370	Gene	Gene	sensitivity|compound|START_ENTITY implications|nmod|sensitivity production|dep|implications production|nmod|END_ENTITY	Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo : implications for enhanced insulin sensitivity .
19755407	0	insulin	81,88	adiponectin	59,70	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY Association|nmod|resistance Association|nmod|G G|nmod|gene gene|compound|END_ENTITY	Association of the +45 T > G and +276 G > T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women .
20376890	0	insulin	105,112	adiponectin	88,99	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Association of plasma retinol-binding_protein_4 , adiponectin , and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients .
20443850	0	insulin	66,73	adiponectin	44,55	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY Association|nmod|resistance Association|nmod|variant variant|nmod|gene gene|compound|END_ENTITY	Association of a polymorphic variant of the adiponectin gene with insulin resistance in african americans .
21306933	0	insulin	36,43	adiponectin	52,63	insulin	adiponectin	3630	9370	Gene	Gene	Intensifying|nmod|START_ENTITY Intensifying|dep|reduces reduces|xcomp|moderately moderately|nsubj|END_ENTITY	Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2 , but not in type 1 , diabetes .
21318144	0	insulin	27,34	adiponectin	65,76	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY mediated|nsubjpass|resistance mediated|nmod|levels levels|compound|END_ENTITY	Hyperthyroidism-associated insulin resistance is not mediated by adiponectin levels .
21458098	0	insulin	60,67	adiponectin	13,24	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY assessment|nmod|resistance END_ENTITY|nmod|assessment	The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic_syndrome in an aged Japanese population : results from the KING Study .
22187345	0	insulin	112,119	adiponectin	16,27	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY relation|nmod|resistance Polymorphism|dep|relation Polymorphism|nmod|END_ENTITY	Polymorphism of adiponectin -LRB- 45T/G -RRB- _ and_adiponectin_receptor-2 -LRB- 795G/A -RRB- in an Iranian population : relation with insulin resistance and response to treatment with pioglitazone in patients with type_2_diabetes_mellitus .
22244787	0	insulin	101,108	adiponectin	45,56	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|adipokines adipokines|appos|END_ENTITY	Visceral fat mass is always , but adipokines -LRB- adiponectin and resistin -RRB- are diversely associated with insulin resistance in Chinese_type_2 diabetic and normoglycemic subjects .
22468049	0	insulin	43,50	adiponectin	15,26	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY Correlation|nmod|resistance Correlation|nmod|END_ENTITY	Correlation of adiponectin and leptin with insulin resistance : a pilot study in healthy north Indian population .
22673293	0	insulin	55,62	adiponectin	16,27	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|Low Low|acl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Low circulating adiponectin levels are associated with insulin resistance in non-obese peritoneal_dialysis patients .
22841521	0	insulin	113,120	adiponectin	37,48	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY marker|nmod|resistance comparison|nmod|marker comparison|nmod|osteoprotegerin osteoprotegerin|nmod|C-reactive_protein C-reactive_protein|compound|END_ENTITY	A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive_protein -LRB- hsCRP -RRB- as a marker for insulin resistance .
23148188	0	insulin	46,53	adiponectin	6,17	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY relation|nmod|resistance Serum|nmod|relation Serum|dobj|END_ENTITY	Serum adiponectin and resistin in relation to insulin resistance and markers of hyperandrogenism_in_lean_and_obese women with polycystic_ovary_syndrome .
23656997	0	insulin	76,83	adiponectin	35,46	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY polymorphisms|dep|resistance polymorphisms|nmod|END_ENTITY	Single-nucleotide polymorphisms in adiponectin , AdipoR1 , and AdipoR2 genes : insulin resistance and type_2_diabetes_mellitus candidate genes .
23958652	0	insulin	62,69	adiponectin	27,38	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY _|nmod|resistance _|dobj|polymorphism polymorphism|compound|END_ENTITY	Association of the + _ 45T > G adiponectin gene polymorphism with insulin resistance in non-diabetic Saudi women .
24405382	0	insulin	69,76	adiponectin	8,19	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY mediating|nmod|resistance END_ENTITY|acl|mediating	Role of adiponectin in mediating the association of osteocalcin with insulin resistance and type 2 diabetes : a cross sectional study in pre - and post-menopausal women .
24640810	0	insulin	39,46	adiponectin	16,27	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY related|nmod|resistance related|nsubj|Status Status|nmod|END_ENTITY	Status of serum adiponectin related to insulin resistance in prediabetics .
25126860	0	insulin	14,21	adiponectin	37,48	insulin	adiponectin	3630	9370	Gene	Gene	Regulation|nmod|START_ENTITY sensitivity|nsubj|Regulation sensitivity|nmod|END_ENTITY	Regulation of insulin sensitivity by adiponectin and its receptors in response to physical exercise .
26139044	0	insulin	70,77	adiponectin	44,55	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|hypermethylation hypermethylation|nmod|gene gene|compound|END_ENTITY	Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance .
26139044	0	insulin	70,77	adiponectin	44,55	insulin	adiponectin	3630	9370	Gene	Gene	resistance|compound|START_ENTITY mediates|dobj|resistance mediates|nsubj|hypermethylation hypermethylation|nmod|gene gene|compound|END_ENTITY	Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance .
26847448	0	insulin	66,73	adiponectin	25,36	insulin	adiponectin	3630	9370	Gene	Gene	level|compound|START_ENTITY fasting|dobj|level associated|xcomp|fasting chemerin|acl|associated fitness|appos|chemerin fitness|appos|END_ENTITY	Cardiopulmonary fitness , adiponectin , chemerin associated fasting insulin level in colorectal_cancer patients .
11994903	0	insulin	100,107	amylin	8,14	insulin	amylin	3630	3375	Gene	Gene	sensitivity|compound|START_ENTITY spectrum|nmod|sensitivity studies|nmod|spectrum Role|dep|studies Role|nmod|END_ENTITY	Role of amylin in insulin secretion and action in humans : antagonist studies across the spectrum of insulin sensitivity .
11994903	0	insulin	18,25	amylin	8,14	insulin	amylin	3630	3375	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Role of amylin in insulin secretion and action in humans : antagonist studies across the spectrum of insulin sensitivity .
1534057	0	insulin	37,44	amylin	27,33	insulin	amylin	3630	24476(Tax:10116)	Gene	Gene	hypersecretion|nmod|START_ENTITY hypersecretion|nmod|END_ENTITY	Relative hypersecretion of amylin to insulin from rat pancreas after neonatal STZ treatment .
2055340	0	insulin	87,94	amylin	49,55	insulin	amylin	3630	3375	Gene	Gene	indicate|nmod|START_ENTITY indicate|nsubj|levels levels|nmod|END_ENTITY	Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans .
2227135	0	insulin	13,20	amylin	43,49	insulin	amylin	3630	3375	Gene	Gene	resistance|compound|START_ENTITY Induction|nmod|resistance Induction|nmod|END_ENTITY	Induction of insulin resistance in vivo by amylin and calcitonin_gene-related_peptide .
3050530	0	insulin	74,81	amylin	11,17	insulin	amylin	3630	3375	Gene	Gene	gene-related|nmod|START_ENTITY gene-related|nsubj|END_ENTITY	Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro .
8477949	0	insulin	36,43	amylin	11,17	insulin	amylin	3630	24476(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of amylin on the release of insulin and glucagon from the perfused rat pancreas .
12691602	0	insulin	112,119	angiotensin_II	94,108	insulin	angiotensin II	3630	183	Gene	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Decreased_insulin_sensitivity during dietary sodium restriction is not mediated by effects of angiotensin_II on insulin action .
8222508	0	insulin	29,36	angiotensin_II	11,25	insulin	angiotensin II	3630	183	Gene	Gene	sensitivity|compound|START_ENTITY END_ENTITY|nmod|sensitivity	Effects of angiotensin_II on insulin sensitivity : a placebo-controlled study .
17982475	0	insulin	59,66	angiotensin_II_type_1_receptor	23,53	insulin	angiotensin II type 1 receptor	3630	185	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Functional coupling of angiotensin_II_type_1_receptor with insulin resistance of energy substrate uptakes in immortalized cardiomyocytes -LRB- HL-1 cells -RRB- .
21306748	0	insulin	49,56	angiotensinogen	23,38	insulin	angiotensinogen	3630	183	Gene	Gene	sensitivity|compound|START_ENTITY gene|nmod|sensitivity gene|compound|END_ENTITY	The association of the angiotensinogen gene with insulin sensitivity in humans : a tagging single nucleotide polymorphism and haplotype approach .
17471492	0	insulin	45,52	aquaporin_3	30,41	insulin	aquaporin 3	3630	360	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of aquaporin_3 by insulin .
7007411	0	insulin	43,50	beta-Endorphin	0,14	insulin	beta-Endorphin	3630	5443	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	beta-Endorphin stimulates the secretion of insulin and glucagon in humans .
20531294	0	insulin	69,76	c-Kit	0,5	insulin	c-Kit	3630	3815	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	c-Kit and stem_cell_factor regulate PANC-1 cell differentiation into insulin - and glucagon-producing cells .
3321056	0	insulin	46,53	casein_kinase_II	14,30	insulin	casein kinase II	3630	1457	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of casein_kinase_II in response to insulin and to epidermal_growth_factor .
25813686	0	insulin	48,55	complement_C3	7,20	insulin	complement C3	3630	718	Gene	Gene	secretion|compound|START_ENTITY associated|nmod|secretion associated|nsubjpass|levels levels|amod|END_ENTITY	Plasma complement_C3 levels are associated with insulin secretion independently of adiposity measures in non-diabetic individuals .
11342583	0	insulin	72,79	endothelin-1	8,20	insulin	endothelin-1	3630	1906	Gene	Gene	desensitization|nmod|START_ENTITY heterologous|dobj|desensitization leads|xcomp|heterologous leads|nsubj|treatment treatment|amod|END_ENTITY	Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes .
12620701	0	insulin	32,39	endothelin-1	8,20	insulin	endothelin-1	3630	1906	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of endothelin-1 induced by insulin in the regulation of vascular cell growth .
1744120	0	insulin	47,54	endothelin-1	15,27	insulin	endothelin-1	280829(Tax:9913)	281137(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of endothelin-1 gene expression by insulin in endothelial cells .
19552740	0	insulin	46,53	erythropoietin	28,42	insulin	erythropoietin	3630	2056	Gene	Gene	resistance|compound|START_ENTITY Effect|nmod|resistance Effect|nmod|END_ENTITY	Effect of recombinant human erythropoietin on insulin resistance in hemodialysis patients .
22387701	0	insulin	52,59	fetuin-A	16,24	insulin	fetuin-A	3630	197	Gene	Gene	resistance|compound|START_ENTITY Relationship|nmod|resistance Relationship|nmod|levels levels|amod|END_ENTITY	Relationship of fetuin-A levels to weight-dependent insulin resistance and type_2_diabetes_mellitus .
16434459	0	insulin	56,63	gamma-glutamyl_transpeptidase	6,35	insulin	gamma-glutamyl transpeptidase	3630	92086	Gene	Gene	resistance|compound|START_ENTITY determinant|nmod|resistance determinant|nsubj|END_ENTITY	Serum gamma-glutamyl_transpeptidase is a determinant of insulin resistance independently of adiposity in Pima Indian children .
6759077	0	insulin	60,67	gastric_inhibitory_polypeptide	12,42	insulin	gastric inhibitory polypeptide	3630	2695	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	The role of gastric_inhibitory_polypeptide in the augmented insulin response to sucrose .
11932320	0	insulin	70,77	gastrin	79,86	insulin	gastrin	3630	2520	Gene	Gene	cholecystokinin|dep|START_ENTITY cholecystokinin|dep|END_ENTITY	A comparison of the effects of pegvisomant and octreotide on glucose , insulin , gastrin , cholecystokinin , and pancreatic_polypeptide responses to oral glucose and a standard mixed meal .
3057484	0	insulin	35,42	gastrin	13,20	insulin	gastrin	3630	2520	Gene	Gene	secretion|compound|START_ENTITY regulating|dobj|secretion -LSB-|advcl|regulating -LSB-|dobj|role role|nmod|END_ENTITY	-LSB- The role of gastrin in regulating insulin and glucagon secretion in patients with diabetes_mellitus -RSB- .
40312	0	insulin	49,56	gastrin	30,37	insulin	gastrin	3630	2520	Gene	Gene	hypoglycemia|compound|START_ENTITY release|nmod|hypoglycemia release|nsubj|Significance Significance|nmod|pH pH|nmod|END_ENTITY	Significance of antral pH for gastrin release by insulin hypoglycemia in duodenal_ulcer patients .
4888657	0	insulin	37,44	gastrin	11,18	insulin	gastrin	3630	2520	Gene	Gene	release|nmod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of gastrin on the release of insulin in vitro .
834973	0	insulin	14,21	gastrin	54,61	insulin	gastrin	3630	2520	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|END_ENTITY	The effect of insulin on food-stimulated secretion of gastrin after parietal cell vagotomy and selective gastric vagotomy .
996432	0	insulin	44,51	gastrin	23,30	insulin	gastrin	3630	2520	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Gastric_acid and serum gastrin responses to insulin and 2-deoxy-d-glucose in duodenal ulcer patients before and after partial gastrectomy .
12193567	0	insulin	133,140	glucagon-like_peptide-1	81,104	insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	synthesis|compound|START_ENTITY regulates|dobj|synthesis regulates|nsubj|Transfection Transfection|nmod|beta-cells beta-cells|nmod|encoding encoding|nmod|END_ENTITY	Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like_peptide-1 regulates glucose-dependent insulin synthesis and secretion .
16091500	0	insulin	32,39	glucagon-like_peptide-1	119,142	insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	analysis|nmod|START_ENTITY pulses|nsubj|analysis pulses|dobj|administration administration|nmod|diabetes diabetes|amod|END_ENTITY	Deconvolution analysis of rapid insulin pulses before and after six weeks of continuous subcutaneous administration of glucagon-like_peptide-1 in elderly patients with type 2 diabetes .
18792870	0	insulin	118,125	glucagon-like_peptide-1	33,56	insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubj|role role|nmod|END_ENTITY	The potential beneficial role of glucagon-like_peptide-1 in endothelial_dysfunction and heart_failure associated with insulin resistance .
26759261	0	insulin	68,75	glucagon-like_peptide-1	43,66	insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	C-peptide|dep|START_ENTITY C-peptide|compound|END_ENTITY	Effect of meal composition on postprandial glucagon-like_peptide-1 , insulin , glucagon , C-peptide , and glucose responses in overweight/obese subjects .
7627258	0	insulin	17,24	glucagon-like_peptide-1	88,111	insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY secretion|dep|role role|nmod|amide amide|amod|END_ENTITY	Highly increased insulin secretion in a patient with postprandial_hypoglycemia : role of glucagon-like_peptide-1 -LRB- 7-36 -RRB- amide .
8819215	0	insulin	110,117	glucagon-like_peptide-1	35,58	insulin	glucagon-like peptide-1	3630	2641	Gene	Gene	secretion|compound|START_ENTITY hormones|nmod|secretion hormones|dobj|correlates correlates|amod|END_ENTITY	Secretion of the incretin hormones glucagon-like_peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day .
17543346	0	insulin	15,22	glucose	26,33	insulin	insulin	3630	3630	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|transport transport|compound|END_ENTITY	The effects of insulin on glucose and fluid transport in the isolated small intestine of normal rats .
19579180	0	insulin	55,62	glucose-6-phosphatase	14,35	insulin	glucose-6-phosphatase	3630	2538	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of glucose-6-phosphatase gene expression by insulin and metformin .
9685358	0	insulin	113,120	glucose-6-phosphatase	69,90	insulin	glucose-6-phosphatase	3630	2538	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|role role|nmod|3-kinase 3-kinase|nmod|repression repression|nmod|gene gene|amod|END_ENTITY	Central role for phosphatidylinositide 3-kinase in the repression of glucose-6-phosphatase gene transcription by insulin .
10100181	0	insulin	127,134	growth_hormone	26,40	insulin	growth hormone	3630	2688	Gene	Gene	circulating|dobj|START_ENTITY decrease|acl|circulating associated|nmod|decrease associated|nsubj|levels levels|nmod|END_ENTITY	Increased serum levels of growth_hormone and insulin-like_growth_factor-I associated with simultaneous decrease of circulating insulin in postmenopausal women receiving hormone replacement therapy .
10484056	0	insulin	9,16	growth_hormone	50,64	insulin	growth hormone	3630	2688	Gene	Gene	levels|compound|START_ENTITY contribute|nsubj|levels contribute|nmod|response response|amod|END_ENTITY	Elevated insulin levels contribute to the reduced growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in obese subjects .
10516135	0	insulin	52,59	growth_hormone	16,30	insulin	growth hormone	3630	81668(Tax:10116)	Gene	Gene	resistance|compound|START_ENTITY induce|dobj|resistance END_ENTITY|acl|induce	Acute effect of growth_hormone to induce peripheral insulin resistance is independent of FFA and insulin levels in rats .
10628433	0	insulin	29,36	growth_hormone	66,80	insulin	growth hormone	3630	2688	Gene	Gene	increases|nmod|START_ENTITY suppress|nsubj|increases suppress|dobj|secretion secretion|nmod|END_ENTITY	Feeding-induced increases in insulin do not suppress secretion of growth_hormone .
10663217	0	insulin	5,12	growth_hormone	127,141	insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY vary|nsubj|sensitivity vary|nmod|concentrations concentrations|amod|END_ENTITY	Both insulin sensitivity and insulin clearance in children and young adults with type I -LRB- insulin-dependent -RRB- diabetes vary with growth_hormone concentrations and with age .
10703231	0	insulin	92,99	growth_hormone	101,115	insulin	growth hormone	3630	2688	Gene	Gene	factor|appos|START_ENTITY END_ENTITY|nsubj|factor	Relationship_of_insulin-like_growth_factor-I , _ insulin-like_growth factor binding protein-3 , insulin , growth_hormone in cord blood and maternal factors with birth height and birthweight .
11574412	0	insulin	39,46	growth_hormone	66,80	insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY restores|dobj|sensitivity restores|nmod|exposure exposure|amod|END_ENTITY	Pharmacological antilipolysis restores insulin sensitivity during growth_hormone exposure .
1173985	0	insulin	97,104	growth_hormone	29,43	insulin	growth hormone	3630	2688	Gene	Gene	cortisol|nmod|START_ENTITY cortisol|nsubj|study study|nmod|END_ENTITY	A comparative study of serum growth_hormone and plasma cortisol levels in stimulation tests with insulin and propranolol-glucagon .
12637795	0	insulin	44,51	growth_hormone	14,28	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY reduces|dobj|resistance reduces|nsubj|Inhibition Inhibition|nmod|excess excess|amod|END_ENTITY	Inhibition of growth_hormone excess reduces insulin resistance and ovarian_dysfunction in a lean case of polycystic_ovary_syndrome with a growth-hormone-producing pituitary_adenoma .
1322872	0	insulin	20,27	growth_hormone	80,94	insulin	growth hormone	3630	2688	Gene	Gene	levels|compound|START_ENTITY Reduction|nmod|levels restore|nsubj|Reduction restore|dobj|concentration concentration|nmod|END_ENTITY	Reduction of plasma insulin levels does not restore integrated concentration of growth_hormone to normal in obese children .
14702105	0	insulin	62,69	growth_hormone	22,36	insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY roles|nmod|sensitivity roles|nmod|END_ENTITY	The relative roles of growth_hormone and IGF-1 in controlling insulin sensitivity .
15131760	0	insulin	43,50	growth_hormone	51,65	insulin	growth hormone	3630	2688	Gene	Gene	nicotine|nmod|START_ENTITY effects|nmod|nicotine END_ENTITY|nsubj|effects	Acute effects of nicotine on serum glucose insulin growth_hormone and cortisol in healthy smokers .
15296478	0	insulin	11,18	growth_hormone	120,134	insulin	growth hormone	3630	81668(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|comparison comparison|nmod|replacement replacement|amod|END_ENTITY	Effects of insulin -- like growth factor-I treatment on the endocrine pancreas of hypophysectomized rats : comparison with growth_hormone replacement .
16200849	0	insulin	12,19	growth_hormone	38,52	insulin	growth hormone	3630	2688	Gene	Gene	dose|nmod|START_ENTITY dose|nmod|release release|amod|END_ENTITY	Low dose of insulin for assessment of growth_hormone and cortisol release in short children .
16584518	0	insulin	29,36	growth_hormone	11,25	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY Effects|nmod|resistance Effects|nmod|END_ENTITY	Effects of growth_hormone on insulin resistance and atherosclerotic risk factors in obese_type_2 diabetic patients with poor glycaemic control .
19609105	0	insulin	11,18	growth_hormone	77,91	insulin	growth hormone	3630	2688	Gene	Gene	levels|compound|START_ENTITY levels|nmod|treatment treatment|nmod|END_ENTITY	Changes in insulin levels following 6-month treatment with recombinant human growth_hormone in growth_hormone-deficient adults .
1988776	0	insulin	105,112	growth_hormone	10,24	insulin	growth hormone	3630	2688	Gene	Gene	secretion|compound|START_ENTITY affect|nmod|secretion affect|nsubj|secretion secretion|compound|END_ENTITY	Nocturnal growth_hormone secretion does not affect diurnal variations in arginine and glucose-stimulated insulin secretion .
20372873	0	insulin	9,16	growth_hormone	117,131	insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|acl|preserved preserved|nmod|therapy therapy|amod|END_ENTITY	Improved insulin sensitivity , preserved beta cell function and improved whole-body glucose metabolism after low-dose growth_hormone replacement therapy in adults with severe growth_hormone deficiency : a pilot study .
20372873	0	insulin	9,16	growth_hormone	174,188	insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|acl|preserved preserved|nmod|deficiency deficiency|compound|END_ENTITY	Improved insulin sensitivity , preserved beta cell function and improved whole-body glucose metabolism after low-dose growth_hormone replacement therapy in adults with severe growth_hormone deficiency : a pilot study .
20583540	0	insulin	90,97	growth_hormone	11,25	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY patients|nmod|resistance concentrations|nmod|patients concentrations|compound|END_ENTITY	Stimulated growth_hormone concentrations in obese pediatric patients with mild and severe insulin resistance : a pilot study .
22323865	0	insulin	41,48	growth_hormone	99,113	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY compensate|nmod|resistance b-cells|acl|compensate ability|nmod|b-cells restored|nsubjpass|ability restored|nmod|reduction reduction|nmod|END_ENTITY	The ability of b-cells to compensate for insulin resistance is restored with a reduction in excess growth_hormone in Korean acromegalic patients .
22562529	0	insulin	78,85	growth_hormone	58,72	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Insulin-like_growth_factor-I correlates more closely than growth_hormone with insulin resistance and glucose_intolerance in patients with acromegaly .
23011065	0	insulin	76,83	growth_hormone	15,29	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY increase|nmod|resistance ameliorates|dobj|increase ameliorates|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression in growth_hormone during overeating ameliorates the increase in insulin resistance and cardiovascular_disease risk .
2406181	0	insulin	175,182	growth_hormone	20,34	insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|nmod|START_ENTITY decreasing|dobj|sensitivity diabetes_mellitus|advcl|decreasing cause|ccomp|diabetes_mellitus cause|nsubj|spikes spikes|nmod|secretion secretion|amod|END_ENTITY	Nocturnal spikes of growth_hormone secretion cause the dawn phenomenon in type 1 -LRB- insulin-dependent -RRB- diabetes_mellitus by decreasing hepatic -LRB- and extrahepatic -RRB- sensitivity to insulin in the absence of insulin waning .
2406181	0	insulin	201,208	growth_hormone	20,34	insulin	growth hormone	3630	2688	Gene	Gene	absence|nmod|START_ENTITY decreasing|nmod|absence diabetes_mellitus|advcl|decreasing cause|ccomp|diabetes_mellitus cause|nsubj|spikes spikes|nmod|secretion secretion|amod|END_ENTITY	Nocturnal spikes of growth_hormone secretion cause the dawn phenomenon in type 1 -LRB- insulin-dependent -RRB- diabetes_mellitus by decreasing hepatic -LRB- and extrahepatic -RRB- sensitivity to insulin in the absence of insulin waning .
24083170	0	insulin	69,76	growth_hormone	114,128	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY resistance|nmod|children children|nmod|deficiency deficiency|amod|END_ENTITY	Evaluation of left ventricular mass and function , lipid profile , and insulin resistance in Egyptian children with growth_hormone deficiency : A single-center prospective case-control study .
25273336	0	insulin	94,101	growth_hormone	141,155	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY increase|nmod|resistance counteract|dobj|increase capacity|acl|counteract END_ENTITY|nsubj|capacity	Reduction_in_insulin_sensitivity and inadequate b-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth_hormone deficiency during 12 months of growth_hormone treatment .
25273336	0	insulin	94,101	growth_hormone	188,202	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY increase|nmod|resistance counteract|dobj|increase capacity|acl|counteract growth_hormone|nsubj|capacity growth_hormone|nmod|months months|nmod|treatment treatment|amod|END_ENTITY	Reduction_in_insulin_sensitivity and inadequate b-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth_hormone deficiency during 12 months of growth_hormone treatment .
2576005	0	insulin	72,79	growth_hormone	19,33	insulin	growth hormone	3630	2688	Gene	Gene	resistance|compound|START_ENTITY effect|nmod|resistance effect|nmod|END_ENTITY	Combined effect of growth_hormone and cortisol on late posthypoglycemic insulin resistance in humans .
2656349	0	insulin	29,36	growth_hormone	11,25	insulin	growth hormone	3630	2688	Gene	Gene	sensitivity|compound|START_ENTITY Effects|nmod|sensitivity Effects|nmod|END_ENTITY	Effects of growth_hormone on insulin sensitivity and forearm metabolism in normal man .
2986615	0	insulin	48,55	growth_hormone	6,20	insulin	growth hormone	3630	81668(Tax:10116)	Gene	Gene	biosynthesis|compound|START_ENTITY binding|nmod|biosynthesis END_ENTITY|dobj|binding	Human growth_hormone binding and stimulation of insulin biosynthesis in cloned rat insulinoma cells .
3131129	0	insulin	43,50	growth_hormone	140,154	insulin	growth hormone	3630	2688	Gene	Gene	tissue|nmod|START_ENTITY tissue|nmod|treatment treatment|nmod|mice mice|nmod|peptides peptides|nmod|END_ENTITY	Increased sensitivity of adipose tissue to insulin after in vivo treatment of yellow Avy/A obese mice with amino-terminal peptides of human growth_hormone .
3135175	0	insulin	50,57	growth_hormone	26,40	insulin	growth hormone	3630	81668(Tax:10116)	Gene	Gene	action|compound|START_ENTITY enhances|dobj|action enhances|nsubj|peptide peptide|nmod|END_ENTITY	Amino-terminal peptide of growth_hormone enhances insulin action in normal rats .
3137806	0	insulin	40,47	growth_hormone	24,38	insulin	growth hormone	3630	2688	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of growth_hormone , insulin , free thyroxine , thyrotropin , and cortisol in very-low-birth-weight_infants receiving total parenteral nutrition .
3882538	0	insulin	125,132	growth_hormone	67,81	insulin	growth hormone	100009181(Tax:9986)	100356068(Tax:9986)	Gene	Gene	fatty_acids|compound|START_ENTITY levels|nmod|fatty_acids END_ENTITY|nmod|levels	Different acute in vivo effects of bacterial derived and pituitary growth_hormone preparations on plasma levels of glucagon , insulin and free fatty_acids in rabbits .
4168383	0	insulin	31,38	growth_hormone	95,109	insulin	growth hormone	3630	2688	Gene	Gene	hypoglycaemia|compound|START_ENTITY effects|nmod|hypoglycaemia comparison|nmod|effects comparison|nmod|END_ENTITY	A comparison of the effects of insulin hypoglycaemia and arginine infusion on release of human growth_hormone .
4421573	0	insulin	24,31	growth_hormone	45,59	insulin	growth hormone	3630	2688	Gene	Gene	enhancement|nmod|START_ENTITY secretion|nsubj|enhancement secretion|nmod|END_ENTITY	In vitro enhancement of insulin secretion by growth_hormone .
4759592	0	insulin	152,159	growth_hormone	85,99	insulin	growth hormone	3630	2688	Gene	Gene	releasing|nmod|START_ENTITY releasing|nmod|END_ENTITY	Isolation and characterization of a pituitary peptidase specifically releasing , from growth_hormone , a peptide -LRB- somantin -RRB- with antagonistic activity to insulin in vitro .
4874761	0	insulin	28,35	growth_hormone	10,24	insulin	growth hormone	3630	2688	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of growth_hormone on insulin secretion .
4882000	0	insulin	55,62	growth_hormone	35,49	insulin	growth hormone	3630	2688	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effects of pregnancy and chorionic growth_hormone upon insulin secretion .
579023	1	insulin	95,102	growth_hormone	113,127	insulin	growth hormone	3630	2688	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	I. Glucose , insulin and human growth_hormone levels during oral glucose tolerance tests .
6250964	0	insulin	26,33	growth_hormone	83,97	insulin	growth hormone	3630	2688	Gene	Gene	somatomedin|compound|START_ENTITY somatomedin|nmod|END_ENTITY	Association between serum insulin , serum somatomedin and liver receptors for human growth_hormone in streptozotocin diabetes .
6761205	0	insulin	29,36	growth_hormone	11,25	insulin	growth hormone	3630	2688	Gene	Gene	action|compound|START_ENTITY Effects|nmod|action Effects|nmod|END_ENTITY	Effects of growth_hormone on insulin action in man .
7042427	0	insulin	118,125	growth_hormone	127,141	insulin	growth hormone	3630	2688	Gene	Gene	glucose|appos|START_ENTITY glucose|appos|levels levels|compound|END_ENTITY	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise : blood glucose , plasma insulin , growth_hormone , adrenaline and noradrenaline levels .
719939	0	insulin	12,19	growth_hormone	89,103	insulin	growth hormone	3630	2688	Gene	Gene	antagonists|compound|START_ENTITY Changes|nmod|antagonists Changes|dep|reference reference|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Changes of insulin antagonists in juvenile_diabetes_mellitus -- with special reference to growth_hormone and glucagon -RSB- .
7921208	0	insulin	38,45	growth_hormone	10,24	insulin	growth hormone	3630	2688	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|treatment treatment|amod|END_ENTITY	Effect of growth_hormone treatment on insulin secretion and glucose metabolism in prepubertal boys with short_stature .
9440474	0	insulin	68,75	growth_hormone	105,119	insulin	growth hormone	3630	2688	Gene	Gene	requirements|compound|START_ENTITY requirements|acl|consequent consequent|nmod|pulsatility pulsatility|amod|END_ENTITY	Recombinant human insulin-like growth factor-I abolishes changes in insulin requirements consequent upon growth_hormone pulsatility in young adults with type_I_diabetes_mellitus .
946563	0	insulin	30,37	growth_hormone	68,82	insulin	growth hormone	3630	2688	Gene	Gene	response|compound|START_ENTITY sensitivity|nmod|response sensitivity|nmod|influsion influsion|amod|END_ENTITY	Diminished sensitivity of the insulin response to glucose following growth_hormone influsion in man .
1519429	0	insulin	47,54	growth_hormone_releasing_hormone	11,43	insulin	growth hormone releasing hormone	3630	2691	Gene	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	Effects of growth_hormone_releasing_hormone on insulin action and insulin secretion in a hypopituitary patient evaluated by the clamp technique .
24532784	0	insulin	38,45	heat_shock_protein_70	7,28	insulin	heat shock protein 70	3630	3308	Gene	Gene	resistance|compound|START_ENTITY predicts|dobj|resistance predicts|nsubj|END_ENTITY	Muscle heat_shock_protein_70 predicts insulin resistance with aging .
10651758	0	insulin	26,33	insulin	57,64	insulin	insulin	3630	3630	Gene	Gene	Suppression|nmod|START_ENTITY secretion|nsubj|Suppression secretion|nmod|END_ENTITY	Suppression of endogenous insulin secretion by exogenous insulin in patients with insulinoma .
10651758	0	insulin	57,64	insulin	26,33	insulin	insulin	3630	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of endogenous insulin secretion by exogenous insulin in patients with insulinoma .
11151028	0	insulin	23,30	insulin	55,62	insulin	insulin	3630	3630	Gene	Gene	efficient|nsubj|START_ENTITY efficient|nmod|END_ENTITY	Gliclazide and bedtime insulin are more efficient than insulin alone for type 2 diabetic patients with sulfonylurea secondary failure .
11151028	0	insulin	55,62	insulin	23,30	insulin	insulin	3630	3630	Gene	Gene	efficient|nmod|START_ENTITY efficient|nsubj|END_ENTITY	Gliclazide and bedtime insulin are more efficient than insulin alone for type 2 diabetic patients with sulfonylurea secondary failure .
1130563	0	insulin	22,29	insulin	72,79	insulin	insulin	483665(Tax:9615)	483665(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of infusion of insulin into portal vein on hepatic extraction of insulin in anesthetized dogs .
1130563	0	insulin	72,79	insulin	22,29	insulin	insulin	483665(Tax:9615)	483665(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of infusion of insulin into portal vein on hepatic extraction of insulin in anesthetized dogs .
11419927	0	insulin	50,57	insulin	6,13	insulin	insulin	3630	3630	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Basal insulin replacement and use of rapid-acting insulin analogues in patients with type 1 diabetes .
11419927	0	insulin	6,13	insulin	50,57	insulin	insulin	3630	3630	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Basal insulin replacement and use of rapid-acting insulin analogues in patients with type 1 diabetes .
11919130	0	insulin	27,34	insulin	42,49	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Additional lunchtime basal insulin during insulin lispro intensive therapy in a randomized , multicenter , crossover study in adults : a real-life design .
11919130	0	insulin	42,49	insulin	27,34	insulin	insulin	3630	3630	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Additional lunchtime basal insulin during insulin lispro intensive therapy in a randomized , multicenter , crossover study in adults : a real-life design .
1221276	0	insulin	6,13	insulin	80,87	insulin	insulin	3630	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Serum insulin levels in diabetics after subcutaneous administration of Rapitard insulin .
1221276	0	insulin	80,87	insulin	6,13	insulin	insulin	3630	3630	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Serum insulin levels in diabetics after subcutaneous administration of Rapitard insulin .
12524030	0	insulin	44,51	insulin	62,69	insulin	insulin	3630	3630	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	A novel view on the mechanisms of action of insulin and other insulin superfamily peptides : involvement of adenylyl cyclase signaling system .
12524030	0	insulin	62,69	insulin	44,51	insulin	insulin	3630	3630	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	A novel view on the mechanisms of action of insulin and other insulin superfamily peptides : involvement of adenylyl cyclase signaling system .
1343115	0	insulin	63,70	insulin	80,87	insulin	insulin	280829(Tax:9913)	3630	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Metabolic control following transfer from mixed bovine-porcine insulin to human insulin in subjects with IDDM : influence of the presence of insulin antibodies .
1343115	0	insulin	80,87	insulin	63,70	insulin	insulin	3630	280829(Tax:9913)	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Metabolic control following transfer from mixed bovine-porcine insulin to human insulin in subjects with IDDM : influence of the presence of insulin antibodies .
15497510	0	insulin	30,37	insulin	61,68	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Lispro is superior to regular insulin in transient intensive insulin therapy in type 2 diabetes .
15497510	0	insulin	61,68	insulin	30,37	insulin	insulin	3630	3630	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Lispro is superior to regular insulin in transient intensive insulin therapy in type 2 diabetes .
16026374	0	insulin	46,53	insulin	57,64	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	The effect of manipulation of basal pulsatile insulin on insulin action in Type 2 diabetes .
16026374	0	insulin	57,64	insulin	46,53	insulin	insulin	3630	3630	Gene	Gene	action|compound|START_ENTITY END_ENTITY|nmod|action	The effect of manipulation of basal pulsatile insulin on insulin action in Type 2 diabetes .
16523182	0	insulin	25,32	insulin	42,49	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Addition of rapid-acting insulin to basal insulin therapy in type 2 diabetes : indications and modalities .
16523182	0	insulin	42,49	insulin	25,32	insulin	insulin	3630	3630	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Addition of rapid-acting insulin to basal insulin therapy in type 2 diabetes : indications and modalities .
17107225	0	insulin	25,32	insulin	38,45	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|analogs analogs|compound|END_ENTITY	The replacement of human insulin with insulin analogs : a survey conducted in france to determine current and recommended practice .
17107225	0	insulin	38,45	insulin	25,32	insulin	insulin	3630	3630	Gene	Gene	analogs|compound|START_ENTITY END_ENTITY|nmod|analogs	The replacement of human insulin with insulin analogs : a survey conducted in france to determine current and recommended practice .
1737529	0	insulin	17,24	insulin	28,35	insulin	insulin	3630	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of human insulin on insulin binding antibody production in nondiabetic subjects .
1737529	0	insulin	28,35	insulin	17,24	insulin	insulin	3630	3630	Gene	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of human insulin on insulin binding antibody production in nondiabetic subjects .
17443605	0	insulin	12,19	insulin	41,48	insulin	insulin	3630	3630	Gene	Gene	analogues|compound|START_ENTITY analogues|nmod|END_ENTITY	Long-acting insulin analogues versus NPH insulin -LRB- human isophane insulin -RRB- for type_2_diabetes_mellitus .
17443605	0	insulin	41,48	insulin	12,19	insulin	insulin	3630	3630	Gene	Gene	analogues|nmod|START_ENTITY analogues|compound|END_ENTITY	Long-acting insulin analogues versus NPH insulin -LRB- human isophane insulin -RRB- for type_2_diabetes_mellitus .
1799913	0	insulin	60,67	insulin	77,84	insulin	insulin	3630	3630	Gene	Gene	Transfer|nmod|START_ENTITY Transfer|nmod|END_ENTITY	Transfer of patients with diabetes from semisynthetic human insulin to human insulin prepared by recombinant DNA technology using baker 's _ yeast : a double-blind , randomized study .
1799913	0	insulin	77,84	insulin	60,67	insulin	insulin	3630	3630	Gene	Gene	Transfer|nmod|START_ENTITY Transfer|nmod|END_ENTITY	Transfer of patients with diabetes from semisynthetic human insulin to human insulin prepared by recombinant DNA technology using baker 's _ yeast : a double-blind , randomized study .
18027324	0	insulin	113,120	insulin	89,96	insulin	insulin	3630	3630	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Insulin requirement in patients with type 1 diabetes with reduced_renal_function : human insulin versus analogue insulin -RSB- .
18027324	0	insulin	89,96	insulin	113,120	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Insulin requirement in patients with type 1 diabetes with reduced_renal_function : human insulin versus analogue insulin -RSB- .
18495286	0	insulin	12,19	insulin	47,54	insulin	insulin	3630	3630	Gene	Gene	analogues|compound|START_ENTITY analogues|nmod|END_ENTITY	Long-acting insulin analogues versus NPH human insulin in type 2 diabetes : a meta-analysis .
18495286	0	insulin	47,54	insulin	12,19	insulin	insulin	3630	3630	Gene	Gene	analogues|nmod|START_ENTITY analogues|compound|END_ENTITY	Long-acting insulin analogues versus NPH human insulin in type 2 diabetes : a meta-analysis .
19023161	0	insulin	117,124	insulin	67,74	insulin	insulin	3630	3630	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative study of effectiveness of multiple-daily injections of insulin versus twice-daily injections of biphasic insulin in patients with type 2 diabetes .
19023161	0	insulin	67,74	insulin	117,124	insulin	insulin	3630	3630	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative study of effectiveness of multiple-daily injections of insulin versus twice-daily injections of biphasic insulin in patients with type 2 diabetes .
19267715	0	insulin	12,19	insulin	44,51	insulin	insulin	3630	3630	Gene	Gene	analogues|compound|START_ENTITY analogues|nmod|END_ENTITY	Long-acting insulin analogues vs. NPH human insulin in type 1 diabetes .
19267715	0	insulin	44,51	insulin	12,19	insulin	insulin	3630	3630	Gene	Gene	analogues|nmod|START_ENTITY analogues|compound|END_ENTITY	Long-acting insulin analogues vs. NPH human insulin in type 1 diabetes .
19774359	0	insulin	10,17	insulin	50,57	insulin	insulin	3630	3630	Gene	Gene	requirement|compound|START_ENTITY requirement|nmod|END_ENTITY	Increased insulin dose requirement of long-acting insulin analogues in obese patients with type 2 diabetes .
19774359	0	insulin	50,57	insulin	10,17	insulin	insulin	3630	3630	Gene	Gene	requirement|nmod|START_ENTITY requirement|compound|END_ENTITY	Increased insulin dose requirement of long-acting insulin analogues in obese patients with type 2 diabetes .
20105044	0	insulin	9,16	insulin	93,100	insulin	insulin	3630	3630	Gene	Gene	device|compound|START_ENTITY device|dep|results results|nmod|trials trials|acl|using using|dobj|devices devices|compound|END_ENTITY	The best insulin injection pen device for caregivers : results of injection trials using five insulin injection devices .
20105044	0	insulin	93,100	insulin	9,16	insulin	insulin	3630	3630	Gene	Gene	devices|compound|START_ENTITY using|dobj|devices trials|acl|using results|nmod|trials device|dep|results device|compound|END_ENTITY	The best insulin injection pen device for caregivers : results of injection trials using five insulin injection devices .
20185734	0	insulin	5,12	insulin	59,66	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Oral insulin : a comparison with subcutaneous regular human insulin in patients with type 2 diabetes .
20185734	0	insulin	59,66	insulin	5,12	insulin	insulin	3630	3630	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Oral insulin : a comparison with subcutaneous regular human insulin in patients with type 2 diabetes .
2115686	1	insulin	158,165	insulin	215,222	insulin	insulin	3630	3630	Gene	Gene	administration|compound|START_ENTITY administration|acl|using using|dobj|-RSB- -RSB-|compound|END_ENTITY	Randomized study between evening and morning intermediary insulin administration using the Novo Pen semi-automatic insulin injector -RSB- .
2115686	1	insulin	215,222	insulin	158,165	insulin	insulin	3630	3630	Gene	Gene	-RSB-|compound|START_ENTITY using|dobj|-RSB- administration|acl|using administration|compound|END_ENTITY	Randomized study between evening and morning intermediary insulin administration using the Novo Pen semi-automatic insulin injector -RSB- .
22136802	0	insulin	54,61	insulin	90,97	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Layer-by-layer films composed of poly -LRB- allylamine -RRB- and insulin for pH-triggered release of insulin .
22136802	0	insulin	90,97	insulin	54,61	insulin	insulin	3630	3630	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Layer-by-layer films composed of poly -LRB- allylamine -RRB- and insulin for pH-triggered release of insulin .
22681724	0	insulin	25,32	insulin	46,53	insulin	insulin	3630	3630	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin .
22681724	0	insulin	46,53	insulin	25,32	insulin	insulin	3630	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin .
23105828	0	insulin	11,18	insulin	59,66	insulin	insulin	3630	3630	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Effects of insulin , glimepiride and combination therapy of insulin and metformin on blood sugar and lipid profile of NIDDM patients .
23105828	0	insulin	59,66	insulin	11,18	insulin	insulin	3630	3630	Gene	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Effects of insulin , glimepiride and combination therapy of insulin and metformin on blood sugar and lipid profile of NIDDM patients .
24683100	0	insulin	22,29	insulin	77,84	insulin	insulin	3630	3630	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Biological effects of insulin and its analogs on cancer cells with different insulin family receptor expression .
24683100	0	insulin	77,84	insulin	22,29	insulin	insulin	3630	3630	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Biological effects of insulin and its analogs on cancer cells with different insulin family receptor expression .
25365322	0	insulin	37,44	insulin	77,84	insulin	insulin	3630	3630	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Fibroblast_growth_factor_21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived -LRB- hASC -RRB- adipocytes .
25365322	0	insulin	77,84	insulin	37,44	insulin	insulin	3630	3630	Gene	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Fibroblast_growth_factor_21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived -LRB- hASC -RRB- adipocytes .
2951136	0	insulin	35,42	insulin	56,63	insulin	insulin	3630	3630	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of biosynthetic human insulin with porcine insulin in the blood_glucose control of diabetic pregnancy .
2951136	0	insulin	56,63	insulin	35,42	insulin	insulin	3630	3630	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of biosynthetic human insulin with porcine insulin in the blood_glucose control of diabetic pregnancy .
3510002	0	insulin	32,39	insulin	43,50	insulin	insulin	3630	3630	Gene	Gene	circulating|dobj|START_ENTITY circulating|nmod|END_ENTITY	Characterization of circulating insulin in insulin autoimmune_syndrome .
3510002	0	insulin	43,50	insulin	32,39	insulin	insulin	3630	3630	Gene	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	Characterization of circulating insulin in insulin autoimmune_syndrome .
3517644	0	insulin	36,43	insulin	47,54	insulin	insulin	3630	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|action action|compound|END_ENTITY	Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent_diabetes_mellitus .
3517644	0	insulin	47,54	insulin	36,43	insulin	insulin	3630	3630	Gene	Gene	action|compound|START_ENTITY Effects|nmod|action Effects|nmod|END_ENTITY	Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent_diabetes_mellitus .
3527523	0	insulin	17,24	insulin	58,65	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Human ultralente insulin : a comparison with porcine lente insulin as a twice-daily insulin in insulin-dependent diabetic patients with fasting hyperglycaemia .
3527523	0	insulin	58,65	insulin	17,24	insulin	insulin	3630	3630	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Human ultralente insulin : a comparison with porcine lente insulin as a twice-daily insulin in insulin-dependent diabetic patients with fasting hyperglycaemia .
403600	0	insulin	40,47	insulin	9,16	insulin	insulin	3630	3630	Gene	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	-LSB- Loss of insulin during the infusion of insulin in glucose and nutrient solutions -RSB- .
403600	0	insulin	9,16	insulin	40,47	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	-LSB- Loss of insulin during the infusion of insulin in glucose and nutrient solutions -RSB- .
4939147	0	insulin	14,21	insulin	45,52	insulin	insulin	3630	3630	Gene	Gene	Inhibition|nmod|START_ENTITY release|nsubj|Inhibition release|nmod|END_ENTITY	Inhibition of insulin release by endogeneous insulin in vitro .
4939147	0	insulin	45,52	insulin	14,21	insulin	insulin	3630	3630	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of insulin release by endogeneous insulin in vitro .
7016345	0	insulin	57,64	insulin	70,77	insulin	insulin	3630	3630	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	The induction of cell-mediated immunity and tolerance to insulin with insulin coupled to syngeneic lymphoid cells .
7016345	0	insulin	70,77	insulin	57,64	insulin	insulin	3630	3630	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	The induction of cell-mediated immunity and tolerance to insulin with insulin coupled to syngeneic lymphoid cells .
7647398	0	insulin	101,108	insulin	49,56	insulin	insulin	3630	3630	Gene	Gene	sensitivity|nmod|START_ENTITY sensitivity|compound|END_ENTITY	Correlation of plasma free thyroxine levels with insulin sensitivity and metabolic clearance rate of insulin in patients with hyperthyroid_Graves ' disease .
7647398	0	insulin	49,56	insulin	101,108	insulin	insulin	3630	3630	Gene	Gene	sensitivity|compound|START_ENTITY sensitivity|nmod|END_ENTITY	Correlation of plasma free thyroxine levels with insulin sensitivity and metabolic clearance rate of insulin in patients with hyperthyroid_Graves ' disease .
7926339	0	insulin	23,30	insulin	34,41	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Variable regulation by insulin of insulin gene expression in HIT-T15 cells .
7926339	0	insulin	34,41	insulin	23,30	insulin	insulin	3630	3630	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Variable regulation by insulin of insulin gene expression in HIT-T15 cells .
8111076	0	insulin	23,30	insulin	57,64	insulin	insulin	3630	3630	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Feedback inhibition of insulin and glucagon secretion by insulin is altered in abdominal_obesity with normal or impaired_glucose_tolerance .
8111076	0	insulin	57,64	insulin	23,30	insulin	insulin	3630	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Feedback inhibition of insulin and glucagon secretion by insulin is altered in abdominal_obesity with normal or impaired_glucose_tolerance .
9059766	0	insulin	46,53	insulin	76,83	insulin	insulin	3630	3630	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Short-term effects of continuous subcutaneous insulin infusion treatment on insulin secretion in non-insulin-dependent overweight patients with poor glycaemic control despite maximal oral anti-diabetic treatment .
9059766	0	insulin	76,83	insulin	46,53	insulin	insulin	3630	3630	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Short-term effects of continuous subcutaneous insulin infusion treatment on insulin secretion in non-insulin-dependent overweight patients with poor glycaemic control despite maximal oral anti-diabetic treatment .
11445561	0	insulin	45,52	insulin-like_growth_factor_binding_protein-1	100,144	insulin	insulin-like growth factor binding protein-1	3630	3484	Gene	Gene	mechanisms|nmod|START_ENTITY inhibition|nsubj|mechanisms inhibition|nmod|transcription transcription|amod|END_ENTITY	Gene - and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like_growth_factor_binding_protein-1 and phosphoenolpyruvate_carboxykinase transcription .
19164337	0	insulin	96,103	insulin-like_growth_factor_binding_protein-1	6,50	insulin	insulin-like growth factor binding protein-1	3630	3484	Gene	Gene	sensitivity|compound|START_ENTITY indices|nmod|sensitivity improvement|nmod|indices improvement|dep|END_ENTITY	Serum insulin-like_growth_factor_binding_protein-1 : an improvement over other simple indices of insulin sensitivity in the assessment of subjects with normal glucose tolerance .
24056811	0	insulin	84,91	insulin-like_growth_factor_binding_protein-1	6,50	insulin	insulin-like growth factor binding protein-1	3630	3484	Gene	Gene	resistance|compound|START_ENTITY marker|nmod|resistance Delta|dep|marker Delta|nummod|END_ENTITY	Delta insulin-like_growth_factor_binding_protein-1 -LRB- / \ IGFBP-1 -RRB- : a marker of hepatic insulin resistance ?
2469133	0	insulin	10,17	insulin_receptor	92,108	insulin	insulin receptor	3630	3643	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of insulin on the growth of a human hepatoma cell line PLC/PRF/5 : a possible role of insulin_receptor .
16339124	0	insulin	66,73	interleukin-18	18,32	insulin	interleukin-18	3630	3606	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubj|role role|nmod|END_ENTITY	Potential role of interleukin-18 in liver_disease associated with insulin resistance .
2125218	0	insulin	10,17	interleukin-1_beta	49,67	insulin	interleukin-1 beta	3630	3553	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Inhibited insulin secretion by recombinant human interleukin-1_beta in adrenalectomized rats : involvement of prostaglandin .
2521822	0	insulin	48,55	interleukin-1_beta	108,126	insulin	interleukin-1 beta	3630	3553	Gene	Gene	secretion|compound|START_ENTITY inhibition|nmod|secretion causing|dobj|inhibition causing|nmod|islets islets|acl|exposed exposed|nmod|END_ENTITY	Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1_beta indicate a perturbation in the mitochondrial function .
8655918	0	insulin	51,58	interleukin-1_beta	21,39	insulin	interleukin-1 beta	3630	3553	Gene	Gene	secretion|compound|START_ENTITY dependence|nmod|secretion dependence|nmod|effects effects|amod|END_ENTITY	The pH dependence of interleukin-1_beta effects on insulin secretion in HIT cells .
15242694	0	insulin	63,70	interleukin-6	30,43	insulin	interleukin-6	3630	3569	Gene	Gene	correlate|compound|START_ENTITY correlate|amod|END_ENTITY	Tumour necrosis factor-alpha , interleukin-6 , and fasting serum insulin correlate with clinical outcome in metastatic breast_cancer patients treated with chemotherapy .
16043746	0	insulin	81,88	interleukin-6	43,56	insulin	interleukin-6	3630	3569	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|polymorphism polymorphism|nmod|promoter promoter|nmod|gene gene|amod|END_ENTITY	C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance .
16804071	0	insulin	62,69	interleukin-6	7,20	insulin	interleukin-6	3630	3569	Gene	Gene	secretion|compound|START_ENTITY associated|nmod|secretion associated|nsubjpass|levels levels|amod|END_ENTITY	Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects .
16984279	0	insulin	66,73	interleukin-6	12,25	insulin	interleukin-6	3630	3569	Gene	Gene	resistance|compound|START_ENTITY related|nmod|resistance related|nsubjpass|Increase Increase|nmod|arterial_injury arterial_injury|amod|END_ENTITY	Increase in interleukin-6 following arterial_injury is related to insulin resistance , the -174 G -- > C polymorphism and complex plaque morphology .
17392554	0	insulin	92,99	interleukin-6	6,19	insulin	interleukin-6	3630	3569	Gene	Gene	sensitivity|compound|START_ENTITY men|nmod|sensitivity endothelial_dysfunction|nmod|men Serum|nmod|endothelial_dysfunction Serum|dobj|correlates correlates|amod|END_ENTITY	Serum interleukin-6 correlates with endothelial_dysfunction in healthy men independently of insulin sensitivity .
17584642	0	insulin	88,95	interleukin-6	22,35	insulin	interleukin-6	3630	3569	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	-LSB- Association of serum interleukin-6 and high-sensitivity C-reactive protein levels with insulin resistance in gestational_diabetes_mellitus -RSB- .
17956545	0	insulin	29,36	interleukin-6	12,25	insulin	interleukin-6	3630	3569	Gene	Gene	resistance|compound|START_ENTITY role|nmod|resistance role|nmod|END_ENTITY	The role of interleukin-6 in insulin resistance , body fat distribution and energy balance .
20731126	0	insulin	47,54	interleukin-6	14,27	insulin	interleukin-6	3630	3569	Gene	Gene	development|nmod|START_ENTITY END_ENTITY|nmod|development	-LSB- Dual role of interleukin-6 for development of insulin resistance -RSB- .
24063815	0	insulin	44,51	interleukin-6	84,97	insulin	interleukin-6	3630	16193(Tax:10090)	Gene	Gene	improvement|nmod|START_ENTITY sensitivity|nsubj|improvement sensitivity|nmod|delivery delivery|nmod|END_ENTITY	Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type_II_diabetes .
2692401	0	insulin	10,17	interleukin_2	39,52	insulin	interleukin 2	3630	3558	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of insulin on the production of interleukin_2 by T lymphocytes .
24057291	0	insulin	34,41	irisin	12,18	insulin	irisin	3630	252995	Gene	Gene	resistance|compound|START_ENTITY relation|nmod|resistance END_ENTITY|nmod|relation	Circulating irisin in relation to insulin resistance and the metabolic_syndrome .
7030721	0	insulin	46,53	islet-activating_protein	10,34	insulin	islet-activating protein	3630	3375	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of islet-activating_protein -LRB- IAP -RRB- upon insulin secretion from human pancreatic islets .
10077355	0	insulin	50,57	leptin	40,46	insulin	leptin	3630	3952	Gene	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of free and specifically bound leptin to insulin secretion in patients with impaired_glucose_tolerance -LRB- IGT -RRB- .
10720074	0	insulin	31,38	leptin	64,70	insulin	leptin	3630	3952	Gene	Gene	metabolism|nmod|START_ENTITY determinant|nsubj|metabolism determinant|nmod|secretion secretion|compound|END_ENTITY	Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans .
10778875	0	insulin	96,103	leptin	29,35	insulin	leptin	3630	3952	Gene	Gene	subjects|nmod|START_ENTITY fasting|nmod|subjects fasting|dobj|concentrations concentrations|compound|END_ENTITY	Comparison of fasting plasma leptin concentrations in healthy subjects with high and low plasma insulin .
10778883	0	insulin	7,14	leptin	62,68	insulin	leptin	3630	3952	Gene	Gene	concentration|compound|START_ENTITY linked|nsubjpass|concentration linked|nmod|concentration concentration|compound|END_ENTITY	Plasma insulin concentration is more tightly linked to plasma leptin concentration than is the body mass index .
10856891	0	insulin	12,19	leptin	138,144	insulin	leptin	105613195	443534(Tax:9940)	Gene	Gene	have|nsubj|START_ENTITY have|dobj|effects effects|dep|development development|nmod|ELISA ELISA|compound|END_ENTITY	Adrenaline , insulin and glucagon do not have acute effects on plasma leptin levels in sheep : development and characterisation of an ovine leptin ELISA .
10856891	0	insulin	12,19	leptin	69,75	insulin	leptin	105613195	443534(Tax:9940)	Gene	Gene	have|nsubj|START_ENTITY have|dobj|effects effects|nmod|levels levels|compound|END_ENTITY	Adrenaline , insulin and glucagon do not have acute effects on plasma leptin levels in sheep : development and characterisation of an ovine leptin ELISA .
11036882	0	insulin	16,23	leptin	27,33	insulin	leptin	3630	3952	Gene	Gene	START_ENTITY|nmod|maintenance maintenance|compound|END_ENTITY	Crucial role of insulin in leptin maintenance : profound decrease in serum leptin by octreotide_acetate in insulinoma subjects .
11036882	0	insulin	16,23	leptin	74,80	insulin	leptin	3630	3952	Gene	Gene	role|nmod|START_ENTITY role|dep|decrease decrease|nmod|END_ENTITY	Crucial role of insulin in leptin maintenance : profound decrease in serum leptin by octreotide_acetate in insulinoma subjects .
11074239	0	insulin	71,78	leptin	6,12	insulin	leptin	3630	3952	Gene	Gene	levels|compound|START_ENTITY relation|nmod|levels levels|dep|relation levels|compound|END_ENTITY	Serum leptin levels in type 1 diabetic_and_obese children : relation to insulin levels .
11095459	0	insulin	8,15	leptin	40,46	insulin	leptin	3630	3952	Gene	Gene	levels|compound|START_ENTITY influence|nsubj|levels influence|dobj|levels levels|compound|END_ENTITY	Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity : evidence from both a cross-sectional and an intervention study .
11150869	0	insulin	56,63	leptin	16,22	insulin	leptin	3630	3952	Gene	Gene	plasma|nmod|START_ENTITY plasma|dobj|levels levels|compound|END_ENTITY	Maternal plasma leptin levels and their relationship to insulin and glucose in gestational-onset diabetes .
11231983	0	insulin	95,102	leptin	33,39	insulin	leptin	3630	3952	Gene	Gene	relationships|nmod|START_ENTITY patterns|dep|relationships patterns|acl|circulating circulating|dobj|levels levels|compound|END_ENTITY	Temporal patterns of circulating leptin levels in lean and obese adolescents : relationships to insulin , growth hormone , and free fatty_acids rhythmicity .
11318790	0	insulin	11,18	leptin	46,52	insulin	leptin	3630	3952	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|system system|compound|END_ENTITY	Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin .
11318790	0	insulin	11,18	leptin	86,92	insulin	leptin	3630	3952	Gene	Gene	Effects|nmod|START_ENTITY mediated|nsubjpass|Effects mediated|nmod|END_ENTITY	Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin .
11967223	0	insulin	63,70	leptin	38,44	insulin	leptin	280829(Tax:9913)	280836(Tax:9913)	Gene	Gene	normalizes|dobj|START_ENTITY normalizes|nsubj|infusion infusion|nmod|END_ENTITY	Central infusion of recombinant ovine leptin normalizes plasma insulin and stimulates a novel hypersecretion of luteinizing hormone after short-term fasting in mature beef cows .
12039705	0	insulin	11,18	leptin	54,60	insulin	leptin	3630	3952	Gene	Gene	pulse|nmod|START_ENTITY stimulates|nsubj|pulse stimulates|dobj|END_ENTITY	A pulse of insulin and dexamethasone stimulates serum leptin in fasting human subjects .
12075578	0	insulin	37,44	leptin	63,69	insulin	leptin	3630	3952	Gene	Gene	resistance|compound|START_ENTITY induced|dobj|resistance induced|nmod|response response|compound|END_ENTITY	The effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemia .
12881203	0	insulin	10,17	leptin	47,53	insulin	leptin	280829(Tax:9913)	280836(Tax:9913)	Gene	Gene	hormone|compound|START_ENTITY Effect|nmod|hormone Effect|nmod|END_ENTITY	Effect of insulin and growth hormone on plasma leptin in periparturient dairy cows .
12895305	0	insulin	57,64	leptin	17,23	insulin	leptin	3630	3952	Gene	Gene	plasma|nmod|START_ENTITY plasma|dobj|levels levels|compound|END_ENTITY	-LSB- Maternal plasma leptin levels and their relationship to insulin and glucose in pregnant women with gestational_diabetes_mellitus and gestational_impaired_glucose_tolerance -RSB- .
12920661	0	insulin	10,17	leptin	36,42	insulin	leptin	3630	3952	Gene	Gene	therapy|compound|START_ENTITY Effect|nmod|therapy Effect|nmod|END_ENTITY	Effect of insulin therapy on plasma leptin and body weight in patients with type 2 diabetes .
14655846	0	insulin	22,29	leptin	7,13	insulin	leptin	3630	3952	Gene	Gene	secretion|compound|START_ENTITY levels|appos|secretion levels|compound|END_ENTITY	Plasma leptin levels , insulin secretion , clearance and action on glucose metabolism in anorexia_nervosa .
14993909	0	insulin	33,40	leptin	7,13	insulin	leptin	3630	3952	Gene	Gene	independent|compound|START_ENTITY associated|nmod|independent associated|nsubjpass|END_ENTITY	Plasma leptin is associated with insulin resistance independent of age , body mass index , fat mass , lipids , and pubertal development in nondiabetic adolescents .
18521457	0	insulin	27,34	leptin	15,21	insulin	leptin	3630	3952	Gene	Gene	resistance|compound|START_ENTITY Association|nmod|resistance Association|nmod|END_ENTITY	Association of leptin with insulin resistance , body composition , and lipid parameters in postmenopausal women and men in type_2_diabetes_mellitus .
18726828	0	insulin	17,24	leptin	180,186	insulin	leptin	3630	3952	Gene	Gene	rates|compound|START_ENTITY Deconvolution|nmod|rates Deconvolution|dep|course course|nmod|homeostasis homeostasis|nmod|treatment treatment|amod|END_ENTITY	Deconvolution of insulin secretion , insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals : time course of glucose homeostasis in leptin replacement treatment .
18726828	0	insulin	36,43	leptin	180,186	insulin	leptin	3630	3952	Gene	Gene	rates|compound|START_ENTITY Deconvolution|nmod|rates Deconvolution|dep|course course|nmod|homeostasis homeostasis|nmod|treatment treatment|amod|END_ENTITY	Deconvolution of insulin secretion , insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals : time course of glucose homeostasis in leptin replacement treatment .
19419266	0	insulin	79,86	leptin	21,27	insulin	leptin	3630	3952	Gene	Gene	resistance|compound|START_ENTITY levels|nmod|resistance levels|compound|END_ENTITY	Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic_syndrome : the key role of central_obesity .
19579977	0	insulin	68,75	leptin	17,23	insulin	leptin	3630	3952	Gene	Gene	level|compound|START_ENTITY END_ENTITY|nmod|level	Circulation free leptin in diabetic patients and its correlation to insulin level .
20484473	0	insulin	54,61	leptin	15,21	insulin	leptin	3630	3952	Gene	Gene	sensitivity|compound|START_ENTITY measure|nmod|sensitivity measure|nsubj|level level|compound|END_ENTITY	Fasting plasma leptin level is a surrogate measure of insulin sensitivity .
21411512	0	insulin	52,59	leptin	18,24	insulin	leptin	3630	3952	Gene	Gene	action|compound|START_ENTITY improve|dobj|action improve|nsubj|treatment treatment|compound|END_ENTITY	Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes .
23266767	0	insulin	34,41	leptin	8,14	insulin	leptin	3630	3952	Gene	Gene	resistance|compound|START_ENTITY Role|nmod|resistance Role|nmod|END_ENTITY	Role of leptin and adiponectin in insulin resistance .
23565488	0	insulin	35,42	leptin	15,21	insulin	leptin	3630	3952	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of leptin secretion by insulin .
23919188	0	insulin	88,95	leptin	6,12	insulin	leptin	3630	3952	Gene	Gene	correlation|nmod|START_ENTITY level|dep|correlation level|compound|END_ENTITY	Serum leptin level in women with polycystic_ovary_syndrome : correlation with adiposity , insulin , and circulating testosterone .
24251168	0	insulin	22,29	leptin	7,13	insulin	leptin	3630	3952	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	Should leptin replace insulin as a lifetime monotherapy for diabetes_type_1_and_2 ?
25870537	0	insulin	15,22	leptin	36,42	insulin	leptin	3630	3952	Gene	Gene	Living|nmod|START_ENTITY role|dep|Living role|nmod|END_ENTITY	Living without insulin : the role of leptin signaling in the hypothalamus .
25995751	0	insulin	73,80	leptin	6,12	insulin	leptin	3630	3952	Gene	Gene	resistance|compound|START_ENTITY levels|nmod|resistance levels|compound|END_ENTITY	Serum leptin levels in gastric_cancer patients and the relationship with insulin resistance .
25995751	0	insulin	73,80	leptin	6,12	insulin	leptin	3630	3952	Gene	Gene	resistance|compound|START_ENTITY levels|nmod|resistance levels|compound|END_ENTITY	Serum leptin levels in gastric_cancer patients and the relationship with insulin resistance .
8621027	0	insulin	29,36	leptin	40,46	insulin	leptin	3630	3952	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Acute and chronic effects of insulin on leptin production in humans : Studies in vivo and in vitro .
8954054	0	insulin	87,94	leptin	52,58	insulin	leptin	3630	3952	Gene	Gene	sensitivity|compound|START_ENTITY changes|nmod|sensitivity END_ENTITY|nmod|changes	Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women .
9130025	0	insulin	72,79	leptin	6,12	insulin	leptin	3630	3952	Gene	Gene	sensitivity|compound|START_ENTITY END_ENTITY|nmod|sensitivity	Serum leptin in subjects with impaired_glucose_tolerance in relation to insulin sensitivity and first-phase insulin response .
9177365	0	insulin	73,80	leptin	6,12	insulin	leptin	3630	3952	Gene	Gene	resistance/hyperinsulinemia|compound|START_ENTITY role|nmod|resistance/hyperinsulinemia levels|dep|role levels|compound|END_ENTITY	Serum leptin levels in women with polycystic_ovary_syndrome : the role of insulin resistance/hyperinsulinemia .
9249764	0	insulin	48,55	leptin	6,12	insulin	leptin	3630	3952	Gene	Gene	concentrations|compound|START_ENTITY independent|nsubj|concentrations plasma|xcomp|independent correlate|xcomp|plasma correlate|nsubj|concentrations concentrations|compound|END_ENTITY	Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic_renal_failure .
9283792	0	insulin	88,95	leptin	43,49	insulin	leptin	3630	3952	Gene	Gene	changes|nmod|START_ENTITY parallel|nmod|changes parallel|nsubj|concentrations concentrations|compound|END_ENTITY	Glibenclamide , but not acarbose , increases leptin concentrations parallel to changes in insulin in subjects with NIDDM .
9588462	0	insulin	78,85	leptin	28,34	insulin	leptin	3630	3952	Gene	Gene	role|nmod|START_ENTITY Overexpression|dep|role Overexpression|nmod|END_ENTITY	Overexpression of placental leptin in diabetic_pregnancy : a critical role for insulin .
9591754	0	insulin	85,92	leptin	19,25	insulin	leptin	3630	3952	Gene	Gene	dependent|nmod|START_ENTITY dependent|csubj|Increase Increase|nmod|END_ENTITY	Increase in plasma leptin and Lep mRNA concentrations by food intake is dependent on insulin .
2471639	0	insulin	55,62	low-density-lipoprotein-receptor	14,46	insulin	low-density-lipoprotein-receptor	3630	3949	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|mRNA mRNA|amod|END_ENTITY	Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells .
21159815	0	insulin	28,35	miR-14	11,17	insulin	miR-14	42549(Tax:7227)	12798384	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Drosophila miR-14 regulates insulin production and metabolism through its target , sugarbabe .
19096044	0	insulin	102,109	miR-30d	91,98	insulin	miR-30d	3630	407033	Gene	Gene	transcription|compound|START_ENTITY END_ENTITY|nmod|transcription	Identification of glucose-regulated miRNAs from pancreatic -LCB- beta -RCB- cells reveals a role for miR-30d in insulin transcription .
14714611	0	insulin	43,50	motilin	10,17	insulin	motilin	483665(Tax:9615)	481748(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of motilin on endogenous release of insulin in conscious dogs in the fed state .
23520133	0	insulin	23,30	neuraminidase_1	44,59	insulin	neuraminidase 1	3630	4758	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Positive regulation of insulin signaling by neuraminidase_1 .
2051998	0	insulin	14,21	ornithine_decarboxylase	30,53	insulin	ornithine decarboxylase	3630	4953	Gene	Gene	Modulation|nmod|START_ENTITY induced|nsubj|Modulation induced|dobj|END_ENTITY	Modulation of insulin induced ornithine_decarboxylase by putrescine and methylputrescines in H-35 hepatoma cells .
7009787	0	insulin	11,18	ornithine_decarboxylase	63,86	insulin	ornithine decarboxylase	280829(Tax:9913)	24609(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|stimulation stimulation|nmod|activity activity|amod|END_ENTITY	Effects of insulin on cultured rat brain cells : stimulation of ornithine_decarboxylase activity .
8397882	0	insulin	16,23	ornithine_decarboxylase	74,97	insulin	ornithine decarboxylase	3630	4953	Gene	Gene	resistance|compound|START_ENTITY suppresses|nsubj|resistance suppresses|dobj|expression expression|nmod|activity activity|compound|END_ENTITY	Ethanol-induced insulin resistance suppresses the expression of embryonic ornithine_decarboxylase activity .
26259649	0	insulin	65,72	osteocalcin	50,61	insulin	osteocalcin	3630	12097(Tax:10090)	Gene	Gene	sensitivity|compound|START_ENTITY END_ENTITY|nmod|sensitivity	The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo .
15700136	0	insulin	118,125	osteoprotegerin	9,24	insulin	osteoprotegerin	3630	4982	Gene	Gene	amounts|nmod|START_ENTITY END_ENTITY|dep|amounts	Arterial osteoprotegerin : increased amounts in diabetes and modifiable synthesis from vascular smooth muscle cells by insulin and TNF-alpha .
16712667	0	insulin	62,69	osteoprotegerin	12,27	insulin	osteoprotegerin	3630	4982	Gene	Gene	steroids|dep|START_ENTITY correlated|nmod|steroids correlated|nsubjpass|END_ENTITY	Circulating osteoprotegerin is correlated with lipid profile , insulin sensitivity , adiponectin and sex steroids in an ageing male population .
17023086	0	insulin	44,51	osteoprotegerin	11,26	insulin	osteoprotegerin	3630	4982	Gene	Gene	therapy|compound|START_ENTITY Changes|nmod|therapy Changes|nmod|END_ENTITY	Changes of osteoprotegerin before and after insulin therapy in type 1 diabetic patients .
22841521	0	insulin	113,120	osteoprotegerin	16,31	insulin	osteoprotegerin	3630	4982	Gene	Gene	resistance|compound|START_ENTITY marker|nmod|resistance comparison|nmod|marker comparison|nmod|END_ENTITY	A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive_protein -LRB- hsCRP -RRB- as a marker for insulin resistance .
23695991	0	insulin	19,26	osteoprotegerin	49,64	insulin	osteoprotegerin	3630	4982	Gene	Gene	resistance|compound|START_ENTITY association|nmod|resistance association|nmod|END_ENTITY	The association of insulin resistance with serum osteoprotegerin in obese adolescents .
26036811	0	insulin	15,22	osteoprotegerin	42,57	insulin	osteoprotegerin	3630	4982	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of insulin and liraglutide on osteoprotegerin and vascular_calcification in vitro and in patients with type 2 diabetes .
8417322	0	insulin	18,25	p21ras	106,112	insulin	p21ras	3630	3265	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Ras activation by insulin and epidermal_growth_factor through enhanced exchange of guanine_nucleotides on p21ras .
15228086	0	insulin	42,49	p38	24,27	insulin	p38	3630	1432	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones .
15228086	0	insulin	53,60	p38	24,27	insulin	p38	3630	1432	Gene	Gene	cells|compound|START_ENTITY Restoration|nmod|cells Restoration|nmod|activation activation|amod|END_ENTITY	Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones .
8626622	0	insulin	54,61	p38	14,17	insulin	p38	396145(Tax:9031)	417553(Tax:9031)	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Inhibition Inhibition|nmod|mitogen-activated_protein mitogen-activated_protein|amod|END_ENTITY	Inhibition of p38 mitogen-activated_protein kinase by insulin in cultured fetal neurons .
16258737	0	insulin	45,52	p70S6k_and_4E-BP1	13,30	insulin	p70S6k and 4E-BP1	3630	1978	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Differential p70S6k_and_4E-BP1 regulation by insulin and amino_acids in vascular endothelial and smooth muscle cells .
11433217	0	insulin	41,48	pen	9,12	insulin	pen	3630	340348	Gene	Gene	therapy|compound|START_ENTITY evolution|nmod|therapy Syringe|dep|evolution Syringe|appos|END_ENTITY	Syringe , pen , inhaler - the evolution of insulin therapy .
14693308	0	insulin	189,196	pen	151,154	insulin	pen	3630	340348	Gene	Gene	injection|compound|START_ENTITY trial|nmod|injection trial|nmod|END_ENTITY	A multicenter , randomized , open-label , comparative , two-period crossover trial of preference , efficacy , and safety profiles of a prefilled , disposable pen and conventional vial/syringe for insulin injection in patients with type 1 or 2 diabetes_mellitus .
15154947	0	insulin	47,54	pen	58,61	insulin	pen	3630	340348	Gene	Gene	assessment|nmod|START_ENTITY assessment|nmod|injectors injectors|compound|END_ENTITY	An assessment of the adequacy of suspension of insulin in pen injectors .
1642530	0	insulin	12,19	pen	90,93	insulin	pen	3630	340348	Gene	Gene	administration|compound|START_ENTITY administration|dep|stabilization stabilization|nmod|END_ENTITY	Independent insulin administration by the hemiplegic patient : stabilization of an insulin pen with a new device .
1751505	0	insulin	45,52	pen	11,14	insulin	pen	3630	340348	Gene	Gene	therapy|compound|START_ENTITY Use|nmod|therapy Use|nmod|system system|compound|END_ENTITY	Use of the pen delivery system for intensive insulin therapy in college-age students with type_I_diabetes .
19075079	0	insulin	40,47	pen	71,74	insulin	pen	3630	340348	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|END_ENTITY	Insulin devices : addressing barriers to insulin therapy with the ideal pen .
19580357	0	insulin	20,27	pen	28,31	insulin	pen	3630	340348	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	The prescription of insulin pen devices versus syringes for older people with diabetes .
19885358	0	insulin	27,34	pen	49,52	insulin	pen	3630	340348	Gene	Gene	delivery|compound|START_ENTITY iPod|dep|delivery pen-the|xcomp|iPod pen-the|parataxis|wins wins|nsubj|END_ENTITY	Insulin pen-the `` iPod '' for insulin delivery -LRB- why pen wins over syringe -RRB- .
20105044	0	insulin	9,16	pen	27,30	insulin	pen	3630	340348	Gene	Gene	device|compound|START_ENTITY device|compound|END_ENTITY	The best insulin injection pen device for caregivers : results of injection trials using five insulin injection devices .
20105044	0	insulin	93,100	pen	27,30	insulin	pen	3630	340348	Gene	Gene	devices|compound|START_ENTITY using|dobj|devices trials|acl|using results|nmod|trials device|dep|results device|compound|END_ENTITY	The best insulin injection pen device for caregivers : results of injection trials using five insulin injection devices .
20513316	0	insulin	21,28	pen	29,32	insulin	pen	3630	340348	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	Practical aspects of insulin pen devices .
22879787	0	insulin	12,19	pen	20,23	insulin	pen	3630	340348	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	A review of insulin pen devices and use in the elderly diabetic population .
22920819	0	insulin	53,60	pen	71,74	insulin	pen	3630	340348	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	Analysis of comparison of patient preference for two insulin injection pen devices in relation to patient dexterity skills .
8306595	0	insulin	10,17	pen	42,45	insulin	pen	3630	340348	Gene	Gene	delivered|nsubj|START_ENTITY delivered|nmod|END_ENTITY	Pre-mixed insulin delivered by disposable pen in the management of children with diabetes .
8529495	0	insulin	48,55	pen	56,59	insulin	pen	3630	340348	Gene	Gene	acceptability|nmod|START_ENTITY END_ENTITY|nsubj|acceptability	Safety , efficacy , acceptability of a pre-filled insulin pen in diabetic patients over 60 years old .
23379644	0	insulin	33,40	pentraxin_3	16,27	insulin	pentraxin 3	3630	5806	Gene	Gene	sensitivity|compound|START_ENTITY END_ENTITY|nmod|sensitivity	Relationship of pentraxin_3 with insulin sensitivity in gestational diabetes .
12957321	0	insulin	105,112	peroxisome_proliferator-activated_receptor-gamma	38,86	insulin	peroxisome proliferator-activated receptor-gamma	3630	5468	Gene	Gene	resistance|compound|START_ENTITY progression|nmod|resistance role|nmod|progression role|nmod|END_ENTITY	The central role of fat and effect of peroxisome_proliferator-activated_receptor-gamma on progression of insulin resistance and cardiovascular_disease .
16508313	0	insulin	115,122	peroxisome_proliferator-activated_receptor_gamma	37,85	insulin	peroxisome proliferator-activated receptor gamma	3630	25664(Tax:10116)	Gene	Gene	resistance|compound|START_ENTITY Effect|nmod|resistance Effect|nmod|END_ENTITY	Effect of aging on the expression of peroxisome_proliferator-activated_receptor_gamma and the possible relation to insulin resistance .
18972094	0	insulin	72,79	phosphatidylinositol_3-kinase	133,162	insulin	phosphatidylinositol 3-kinase	3630	5293	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin_receptor_substrate-1-dependent phosphatidylinositol_3-kinase , atypical protein kinase C and protein kinase B/Akt in human diabetic muscle .
19769745	0	insulin	40,47	phosphoenolpyruvate_carboxykinase	58,91	insulin	phosphoenolpyruvate carboxykinase	3630	5106	Gene	Gene	action|compound|START_ENTITY action|nmod|expression expression|amod|END_ENTITY	Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate_carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells .
3331712	0	insulin	96,103	phosphoenolpyruvate_carboxykinase	18,51	insulin	phosphoenolpyruvate carboxykinase	3630	5106	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The inhibition of phosphoenolpyruvate_carboxykinase -LRB- guanosine_triphosphate -RRB- gene expression by insulin is not mediated by protein kinase C .
6353247	0	insulin	77,84	phosphoenolpyruvate_carboxykinase	35,68	insulin	phosphoenolpyruvate carboxykinase	3630	5106	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Inhibition of transcription of the phosphoenolpyruvate_carboxykinase gene by insulin .
8971075	0	insulin	36,43	phosphoenolpyruvate_carboxykinase	88,121	insulin	phosphoenolpyruvate carboxykinase	3630	5106	Gene	Gene	mimic|dobj|START_ENTITY mimic|advcl|inhibiting inhibiting|dobj|expression expression|nmod|END_ENTITY	Oxidative and chemical stress mimic insulin by selectively inhibiting the expression of phosphoenolpyruvate_carboxykinase in hepatoma cells .
9452431	0	insulin	182,189	phosphoenolpyruvate_carboxykinase	126,159	insulin	phosphoenolpyruvate carboxykinase	3630	5106	Gene	Gene	required|nmod|START_ENTITY required|nmod|repression repression|nmod|transcription transcription|amod|END_ENTITY	Activation of the ras mitogen-activated protein kinase-ribosomal protein kinase pathway is not required for the repression of phosphoenolpyruvate_carboxykinase gene transcription by insulin .
15579757	0	insulin	84,91	proinsulin	54,64	insulin	proinsulin	3630	3630	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Rosiglitazone , but not glyburide , reduces circulating proinsulin and the proinsulin : insulin ratio in type 2 diabetes .
20687898	0	insulin	45,52	protein_kinase_B	67,83	insulin	protein kinase B	3630	2185	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|END_ENTITY	Heart 6-phosphofructo-2-kinase activation by insulin requires PKB -LRB- protein_kinase_B -RRB- , but not SGK3 -LRB- serum - _ and_glucocorticoid-induced_protein_kinase_3 -RRB- .
11577086	0	insulin	86,93	pyruvate_dehydrogenase	109,131	insulin	pyruvate dehydrogenase	3630	54704	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|activity activity|amod|END_ENTITY	Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate_dehydrogenase complex activity in muscle and liver cells .
9438382	0	insulin	64,71	pyruvate_dehydrogenase	29,51	insulin	pyruvate dehydrogenase	3630	54704	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	G proteins and regulation of pyruvate_dehydrogenase activity by insulin in human circulating lymphocytes .
12050208	0	insulin	75,82	resistin	6,14	insulin	resistin	3630	56729	Gene	Gene	sensitivity|compound|START_ENTITY association|nmod|sensitivity scanning|nmod|association gene|dep|scanning gene|compound|END_ENTITY	Human resistin gene : molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians .
12829623	0	insulin	76,83	resistin	58,66	insulin	resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY link|nmod|resistance link|dobj|END_ENTITY	A promoter genotype and oxidative stress potentially link resistin to human insulin resistance .
12830457	0	insulin	56,63	resistin	10,18	insulin	resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|levels levels|compound|END_ENTITY	Increased resistin blood levels are not associated with insulin resistance in patients with renal_disease .
14671216	0	insulin	67,74	resistin	44,52	insulin	resistin	3630	56729	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Resistin and type 2 diabetes : regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes .
16625816	0	insulin	40,47	resistin	12,20	insulin	resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY role|nmod|resistance role|nmod|END_ENTITY	The role of resistin in obesity-induced insulin resistance .
17445546	0	insulin	40,47	resistin	6,14	insulin	resistin	3630	56729	Gene	Gene	sensitivity|compound|START_ENTITY associated|nmod|sensitivity associated|nsubjpass|level level|compound|END_ENTITY	Serum resistin level is associated with insulin sensitivity in Japanese patients with type_2_diabetes_mellitus .
20113417	0	insulin	53,60	resistin	21,29	insulin	resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY Relationship|nmod|resistance Relationship|nmod|levels levels|amod|END_ENTITY	Relationship between resistin and aPAI-1 levels with insulin resistance in Saudi children .
22866969	0	insulin	43,50	resistin	7,15	insulin	resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|levels levels|compound|END_ENTITY	Plasma resistin levels are associated with insulin resistance in older Japanese men from a rural village .
23178185	0	insulin	48,55	resistin	15,23	insulin	resistin	3630	56729	Gene	Gene	resistance|compound|START_ENTITY polymorphisms|nmod|resistance polymorphisms|nsubj|Association Association|nmod|gene gene|compound|END_ENTITY	Association of resistin gene polymorphisms with insulin resistance in Egyptian_obese patients .
19766271	0	insulin	60,67	retinol-binding_protein_4	15,40	insulin	retinol-binding protein 4	3630	5950	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Elevated serum retinol-binding_protein_4 is associated with insulin resistance in older women .
21711373	0	insulin	52,59	retinol-binding_protein_4	21,46	insulin	retinol-binding protein 4	3630	5950	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Association of serum retinol-binding_protein_4 with insulin resistance and metabolic parameters during olanzapine therapy .
1052690	0	insulin	49,56	secretin	37,45	insulin	secretin	3630	6343	Gene	Gene	secretion|compound|START_ENTITY -LSB-|nmod|secretion -LSB-|dobj|effect effect|nmod|END_ENTITY	-LSB- The effect of natural and synthetic secretin on insulin secretion -LRB- author 's transl -RRB- -RSB- .
744171	0	insulin	29,36	secretin	10,18	insulin	secretin	3630	6343	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of secretin on plasma insulin and glucagon in man .
8364	0	insulin	7,14	secretin	86,94	insulin	secretin	3630	6343	Gene	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Plasma insulin concentration during physiological variations in immunoreactive plasma secretin .
166088	0	insulin	55,62	somatostatin	11,23	insulin	somatostatin	3630	6750	Gene	Gene	secretion|compound|START_ENTITY inhibit|dobj|secretion Failure|acl|inhibit Failure|nmod|END_ENTITY	Failure of somatostatin to inhibit tolbutamide-induced insulin secretion in patients with insulinomas : a possible diagnostic tool .
1685991	0	insulin	14,21	somatostatin	96,108	insulin	somatostatin	3630	6750	Gene	Gene	suppression|compound|START_ENTITY effect|nmod|suppression effect|dep|studies studies|nmod|infusion infusion|nmod|END_ENTITY	The effect of insulin suppression on postprandial nutrient metabolism : studies with infusion of somatostatin and insulin .
437378	1	insulin	94,101	somatostatin	59,71	insulin	somatostatin	3630	6750	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of somatostatin and somatostatin plus insulin .
6132675	0	insulin	50,57	somatostatin	20,32	insulin	somatostatin	3630	6750	Gene	Gene	levels|compound|START_ENTITY depression|nmod|levels role|nmod|depression role|nmod|END_ENTITY	A possible role for somatostatin in depression of insulin and glucagon levels during hemorrhage .
8764190	0	insulin	37,44	somatostatin	11,23	insulin	somatostatin	483665(Tax:9615)	403993(Tax:9615)	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effects of somatostatin on pulsatile insulin secretion : elective inhibition of insulin burst mass .
8764190	0	insulin	79,86	somatostatin	11,23	insulin	somatostatin	483665(Tax:9615)	403993(Tax:9615)	Gene	Gene	mass|compound|START_ENTITY inhibition|nmod|mass Effects|dep|inhibition Effects|nmod|END_ENTITY	Effects of somatostatin on pulsatile insulin secretion : elective inhibition of insulin burst mass .
908478	0	insulin	61,68	somatostatin	23,35	insulin	somatostatin	3630	6750	Gene	Gene	ajunct|nmod|START_ENTITY evaluation|nmod|ajunct evaluation|nmod|END_ENTITY	Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes_mellitus .
934480	0	insulin	29,36	somatostatin	55,67	insulin	somatostatin	3630	6750	Gene	Gene	levels|compound|START_ENTITY levels|acl|induced induced|nmod|END_ENTITY	-LSB- Changes in blood sugar , and insulin levels induced by somatostatin in normal , diabetic and acromegalic subjects -RSB- .
23461678	0	insulin	106,113	thioredoxin-interacting_protein	15,46	insulin	thioredoxin-interacting protein	3630	10628	Gene	Gene	resistance|compound|START_ENTITY associated|nmod|resistance associated|nsubjpass|END_ENTITY	Elevated serum thioredoxin-interacting_protein in women with polycystic_ovary_syndrome is associated with insulin resistance .
15914522	0	insulin	10,17	vascular_endothelial_growth_factor	28,62	insulin	vascular endothelial growth factor	3630	7422	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of insulin on plasma vascular_endothelial_growth_factor in children with new-onset diabetes .
3551628	0	insulin	10,17	vasopressin	39,50	insulin	vasopressin	3630	551	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin on osmoregulation of vasopressin .
17582143	0	insulin	30,37	visfatin	6,14	insulin	visfatin	3630	10135	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|nmod|resistance	Serum visfatin in relation to insulin resistance and markers of hyperandrogenism_in_lean_and_obese women with polycystic_ovary_syndrome .
21871642	0	insulin	58,65	vitamin_D_receptor	15,33	insulin	vitamin D receptor	3630	7421	Gene	Gene	resistance|compound|START_ENTITY polymorphisms|nmod|resistance polymorphisms|nsubj|Association Association|nmod|gene gene|compound|END_ENTITY	Association of vitamin_D_receptor gene polymorphisms with insulin resistance and response to vitamin_D .
1836994	0	insulin-degrading_enzyme	70,94	Atrial_natriuretic_peptide	0,26	insulin-degrading enzyme	Atrial natriuretic peptide	25700(Tax:10116)	24602(Tax:10116)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Atrial_natriuretic_peptide -LRB- ANP -RRB- is a high-affinity substrate for rat insulin-degrading_enzyme .
12716770	0	insulin-degrading_enzyme	42,66	IDE	68,71	insulin-degrading enzyme	IDE	3416	3416	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association and haplotype analysis of the insulin-degrading_enzyme -LRB- IDE -RRB- gene , a strong positional and biological candidate for type 2 diabetes susceptibility .
15277398	0	insulin-degrading_enzyme	33,57	IDE	59,62	insulin-degrading enzyme	IDE	3416	3416	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Quantitative trait loci near the insulin-degrading_enzyme -LRB- IDE -RRB- gene contribute to variation in plasma insulin levels .
16380485	0	insulin-degrading_enzyme	64,88	IDE	90,93	insulin-degrading enzyme	IDE	3416	3416	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High-density haplotype structure and association testing of the insulin-degrading_enzyme -LRB- IDE -RRB- gene with type 2 diabetes in 4,206 people .
16914266	0	insulin-degrading_enzyme	53,77	IDE	79,82	insulin-degrading enzyme	IDE	3416	3416	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association of 5 SNPs in the vicinity of the insulin-degrading_enzyme -LRB- IDE -RRB- gene with late-onset Alzheimer 's _ disease .
17613531	0	insulin-degrading_enzyme	34,58	IDE	130,133	insulin-degrading enzyme	IDE	3416	3416	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of substrate-free human insulin-degrading_enzyme -LRB- IDE -RRB- and biophysical analysis of ATP-induced conformational switch of IDE .
19896952	0	insulin-degrading_enzyme	92,116	IGF-II	53,59	insulin-degrading enzyme	IGF-II	3416	3481	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis for the recognition and cleavages of IGF-II , TGF-alpha , and amylin by human insulin-degrading_enzyme .
9514933	0	insulin-degrading_enzyme	52,76	Insulin	0,7	insulin-degrading enzyme	Insulin	3416	3630	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Insulin acts intracellularly on proteasomes through insulin-degrading_enzyme .
19383491	0	insulin-degrading_enzyme	56,80	PPARgamma	0,9	insulin-degrading enzyme	PPARgamma	3416	5468	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PPARgamma transcriptionally regulates the expression of insulin-degrading_enzyme in primary neurons .
10973971	0	insulin-degrading_enzyme	25,49	amylin	15,21	insulin-degrading enzyme	amylin	25700(Tax:10116)	24476(Tax:10116)	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of amylin by insulin-degrading_enzyme .
20145255	0	insulin-induced_gene_2	30,52	INSIG2	54,60	insulin-induced gene 2	INSIG2	51141	51141	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Characterization of the human insulin-induced_gene_2 -LRB- INSIG2 -RRB- promoter : the role of Ets-binding motifs .
25900365	0	insulin-like-growth_factor_binding_protein-2	58,102	Phosphatidylinositol_3-kinase	0,29	insulin-like-growth factor binding protein-2	Phosphatidylinositol 3-kinase	3485	5293	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase -LRB- PI3K -RRB- signalling regulates insulin-like-growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- production in human adipocytes .
16237153	0	insulin-like_3	44,58	NR4A1	28,33	insulin-like 3	NR4A1	16336(Tax:10090)	15370(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	The orphan nuclear receptor NR4A1 regulates insulin-like_3 gene transcription in Leydig cells .
11061561	0	insulin-like_4	47,61	INSL4	63,68	insulin-like 4	INSL4	3641	3641	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of pro-EPIL peptides encoded by the insulin-like_4 -LRB- INSL4 -RRB- gene in chromosomally abnormal pregnancies .
9284764	0	insulin-like_4	61,75	INSL4	77,82	insulin-like 4	INSL4	3641	3641	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Identification of pro-EPIL and EPIL peptides translated from insulin-like_4 -LRB- INSL4 -RRB- mRNA in human placenta .
10650968	0	insulin-like_factor_3	15,36	Insl3	38,43	insulin-like factor 3	Insl3	16336(Tax:10090)	16336(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of insulin-like_factor_3 -LRB- Insl3 -RRB- in diethylstilbestrol-induced cryptorchidism .
17649826	0	insulin-like_growth-factor-1_receptor	14,51	IGF-1R	53,59	insulin-like growth-factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth-factor-1_receptor -LRB- IGF-1R -RRB- in peripheral nerve_sheath_tumors in neurofibromatosis_type_1 .
12952376	0	insulin-like_growth-factor-I	17,45	IGF-I	47,52	insulin-like growth-factor-I	IGF-I	3479	3479	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Circulating free insulin-like_growth-factor-I -LRB- IGF-I -RRB- levels should also be measured to estimate the IGF-I bioactivity .
17127062	0	insulin-like_growth-factor-I_receptor	45,82	IGF-IR	84,90	insulin-like growth-factor-I receptor	IGF-IR	3480	3480	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	1,3-Disubstituted-imidazo -LSB- 1,5-a -RSB- pyrazines as insulin-like_growth-factor-I_receptor -LRB- IGF-IR -RRB- inhibitors .
12556535	0	insulin-like_growth_factor	7,33	ASK1	109,113	insulin-like growth factor	ASK1	3479	4217	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Type 1 insulin-like_growth_factor receptor -LRB- IGF-IR -RRB- signaling inhibits apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- .
12868196	0	insulin-like_growth_factor	17,43	Growth_hormone	1,15	insulin-like growth factor	Growth hormone	3479	2688	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	-LSB- Growth_hormone , insulin-like_growth_factor and insulin-like_growth_factor binding protein in young type_I_diabetes patients with the onset of diabetic_angiopathy -RSB- .
22090255	0	insulin-like_growth_factor	25,51	IGF-1	18,23	insulin-like growth factor	IGF-1	3479	3479	Gene	Gene	therapy|compound|START_ENTITY therapy|compound|END_ENTITY	Recombinant human IGF-1 -LRB- insulin-like_growth_factor -RRB- therapy : where do we stand today ?
24636508	0	insulin-like_growth_factor	83,109	IGF-1	111,116	insulin-like growth factor	IGF-1	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Associations between depressive_symptoms and memory deficits vary as a function of insulin-like_growth_factor -LRB- IGF-1 -RRB- levels in healthy older adults .
11172797	0	insulin-like_growth_factor	55,81	IGF-I	85,90	insulin-like growth factor	IGF-I	3479	3479	Gene	Gene	I|amod|START_ENTITY I|appos|END_ENTITY	Effects of two oral contraceptives on plasma levels of insulin-like_growth_factor I -LRB- IGF-I -RRB- and growth_hormone -LRB- hGH -RRB- .
12771153	0	insulin-like_growth_factor	38,64	IGF-I	66,71	insulin-like growth factor	IGF-I	3479	3479	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Two novel proteins that are linked to insulin-like_growth_factor -LRB- IGF-I -RRB- receptors by the Grb10 adapter and modulate IGF-I signaling .
12556535	0	insulin-like_growth_factor	7,33	IGF-IR	44,50	insulin-like growth factor	IGF-IR	3479	3480	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Type 1 insulin-like_growth_factor receptor -LRB- IGF-IR -RRB- signaling inhibits apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- .
9379683	0	insulin-like_growth_factor	63,89	IL7	40,43	insulin-like growth factor	IL7	3479	3574	Gene	Gene	START_ENTITY|nsubj|effect effect|nmod|END_ENTITY	The effect of cytokines , including IL4 , IL7 , stem_cell_factor , insulin-like_growth_factor on childhood acute_lymphoblastic_leukemia .
22461702	0	insulin-like_growth_factor-1	14,42	Bcl-2	51,56	insulin-like growth factor-1	Bcl-2	3479	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Intracellular insulin-like_growth_factor-1 induces Bcl-2 expression in airway epithelial cells .
22878411	0	insulin-like_growth_factor-1	27,55	Bcl-2	67,72	insulin-like growth factor-1	Bcl-2	16000(Tax:10090)	12043(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|mediate mediate|dobj|expression expression|compound|END_ENTITY	Acute inflammation induces insulin-like_growth_factor-1 to mediate Bcl-2 and Muc5ac expression in airway epithelial cells .
22006370	0	insulin-like_growth_factor-1	11,39	COX-2	65,70	insulin-like growth factor-1	COX-2	16000(Tax:10090)	17709(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Transgenic insulin-like_growth_factor-1 stimulates activation of COX-2 signaling in mammary glands .
17697625	0	insulin-like_growth_factor-1	30,58	Clara_cell_secretory_protein	80,108	insulin-like growth factor-1	Clara cell secretory protein	3479	7356	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of recombinant human insulin-like_growth_factor-1 on the expression of Clara_cell_secretory_protein in lung of hyperoxia-exposed newborn rats -RSB- .
10764896	0	insulin-like_growth_factor-1	16,44	Growth_hormone	0,14	insulin-like growth factor-1	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	factor|nsubj|START_ENTITY factor|advmod|END_ENTITY	Growth_hormone , insulin-like_growth_factor-1 , and the insulin-like growth factor binding proteins in rats maintaining reduced body protein following lesions of the lateral_hypothalamus .
10079033	0	insulin-like_growth_factor-1	18,46	IGF-1	48,53	insulin-like growth factor-1	IGF-1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Quantification of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- mRNA : development and validation of an internally standardised competitive reverse transcription-polymerase chain reaction .
10079034	0	insulin-like_growth_factor-1	18,46	IGF-1	48,53	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Quantification of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- mRNA : modulation of growth intensity by feeding results in inter - and intra-tissue-specific differences of IGF-1 mRNA expression in steers .
10719568	0	insulin-like_growth_factor-1	10,38	IGF-1	40,45	insulin-like growth factor-1	IGF-1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- on muscle and bone growth in experimental models .
10940491	0	insulin-like_growth_factor-1	86,114	IGF-1	116,121	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Tamoxifen-induced cell death in malignant_melanoma cells : possible involvement of the insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- pathway .
1596498	0	insulin-like_growth_factor-1	30,58	IGF-1	60,65	insulin-like growth factor-1	IGF-1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Effect of dietary proteins on insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- messenger ribonucleic_acid content in rat liver .
1651135	0	insulin-like_growth_factor-1	28,56	IGF-1	58,63	insulin-like growth factor-1	IGF-1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Growth-promoting effects of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- on hematopoietic cells : overexpression of introduced IGF-1 receptor abrogates interleukin-3 dependency of murine factor-dependent cells by a ligand-dependent mechanism .
19715680	0	insulin-like_growth_factor-1	8,36	IGF-1	38,43	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- in regulating cell cycle progression .
20044479	0	insulin-like_growth_factor-1	24,52	IGF-1	54,59	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Selective disruption of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- signaling via phosphoinositide-dependent_kinase-1 prevents the protective effect of IGF-1 on human cancer cell death .
20553722	0	insulin-like_growth_factor-1	12,40	IGF-1	42,47	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- in growth and reproduction in female brown house snakes -LRB- Lamprophis fuliginosus -RRB- .
22573330	0	insulin-like_growth_factor-1	14,42	IGF-1	44,49	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- expression by prolonged transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- administration suppresses osteoblast differentiation .
22632366	0	insulin-like_growth_factor-1	8,36	IGF-1	38,43	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Role of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- pathway in the pathogenesis of Graves ' _ orbitopathy .
24272080	0	insulin-like_growth_factor-1	43,71	IGF-1	73,78	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Clinical significance of serum circulating insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- mRNA in hepatocellular_carcinoma .
2850224	0	insulin-like_growth_factor-1	25,53	IGF-1	55,60	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Studies on the roles of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- / somatomedin_C -LRB- SMC -RRB- during pregnancy -RSB- .
7608381	0	insulin-like_growth_factor-1	15,43	IGF-1	45,50	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Elevated serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- levels in women with postadolescent acne .
8435198	0	insulin-like_growth_factor-1	7,35	IGF-1	37,42	insulin-like growth factor-1	IGF-1	3479	3479	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Plasma insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- concentrations in human breast_cancer .
25966067	0	insulin-like_growth_factor-1	68,96	IGF1	98,102	insulin-like growth factor-1	IGF1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Associations between genetic variants in the promoter region of the insulin-like_growth_factor-1 -LRB- IGF1 -RRB- gene and blood serum IGF1 concentration in Hanwoo cattle .
15775992	0	insulin-like_growth_factor-1	23,51	IGFBP-3	87,94	insulin-like growth factor-1	IGFBP-3	3479	3486	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Putative role of serum insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels in the development of prostate_cancer in Arab men .
21245137	0	insulin-like_growth_factor-1	74,102	PPARalpha	108,117	insulin-like growth factor-1	PPARalpha	16000(Tax:10090)	19013(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- gene profiling uncovers insulin-like_growth_factor-1 as a PPARalpha target gene in cardioprotection .
24827675	0	insulin-like_growth_factor-1	48,76	TRPV1	21,26	insulin-like growth factor-1	TRPV1	24482(Tax:10116)	83810(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Enhanced function of TRPV1 via up-regulation by insulin-like_growth_factor-1 in a rat model of bone_cancer_pain .
12356750	0	insulin-like_growth_factor-1	47,75	amphiregulin	27,39	insulin-like growth factor-1	amphiregulin	3479	374	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Inhibition of apoptosis by amphiregulin via an insulin-like_growth_factor-1 receptor-dependent pathway in non-small cell lung_cancer cell lines .
12710528	0	insulin-like_growth_factor-1	14,42	angiotensin-converting_enzyme	134,163	insulin-like growth factor-1	angiotensin-converting enzyme	24482(Tax:10116)	24310(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|amod|END_ENTITY	Regulation of insulin-like_growth_factor-1 by the renin-angiotensin system during regression of cardiac_eccentric_hypertrophy through angiotensin-converting_enzyme inhibitor and AT1 antagonist .
7572578	0	insulin-like_growth_factor-1	45,73	atrial_natriuretic_peptide	17,43	insulin-like growth factor-1	atrial natriuretic peptide	3479	4878	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Acute changes in atrial_natriuretic_peptide , insulin-like_growth_factor-1 , and lactate levels during left anterior descending coronary artery angioplasty .
22799302	0	insulin-like_growth_factor-1	10,38	bone_morphogenetic_protein-2	42,70	insulin-like growth factor-1	bone morphogenetic protein-2	3479	650	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of insulin-like_growth_factor-1 on bone_morphogenetic_protein-2 expression in hepatic_carcinoma SMMC7721 cells through the p38 MAPK signaling pathway .
24064350	0	insulin-like_growth_factor-1	65,93	cAMP_response_element_binding_protein	4,41	insulin-like growth factor-1	cAMP response element binding protein	3479	1385	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	The cAMP_response_element_binding_protein -LRB- CREB -RRB- is activated by insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- and regulates myostatin gene expression in skeletal myoblast .
25472142	0	insulin-like_growth_factor-1	65,93	e-cadherin	22,32	insulin-like growth factor-1	e-cadherin	3479	999	Gene	Gene	function|nmod|START_ENTITY END_ENTITY|nmod|function	93 the involvement of e-cadherin in thermoprotective function of insulin-like_growth_factor-1 in 4-cell hamster embryos .
16890611	0	insulin-like_growth_factor-1	22,50	glucagon-like_peptide-2	87,110	insulin-like growth factor-1	glucagon-like peptide-2	16000(Tax:10090)	93896(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The essential role of insulin-like_growth_factor-1 in the intestinal tropic effects of glucagon-like_peptide-2 in mice .
8767634	0	insulin-like_growth_factor-1	27,55	growth_hormone	12,26	insulin-like growth factor-1	growth hormone	3479	2688	Gene	Gene	axis|amod|START_ENTITY Changes|dep|axis Changes|nmod|END_ENTITY	-LSB- Changes in growth_hormone / insulin-like_growth_factor-1 axis in patients with normal pituitary function and biventricular_cardiac_failure and hepatic_stasis -RSB- .
15830901	0	insulin-like_growth_factor-1	15,43	oct_2	54,59	insulin-like growth factor-1	oct 2	24482(Tax:10116)	117058(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Alcohol alters insulin-like_growth_factor-1 activated oct_2 POU domain gene expression in the immature female hypothalamus .
20044479	0	insulin-like_growth_factor-1	24,52	phosphoinositide-dependent_kinase-1	75,110	insulin-like growth factor-1	phosphoinositide-dependent kinase-1	3479	5163	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Selective disruption of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- signaling via phosphoinositide-dependent_kinase-1 prevents the protective effect of IGF-1 on human cancer cell death .
15968405	0	insulin-like_growth_factor-1	78,106	plasminogen_activator_inhibitor-1	30,63	insulin-like growth factor-1	plasminogen activator inhibitor-1	3479	5054	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional regulation of plasminogen_activator_inhibitor-1 expression by insulin-like_growth_factor-1 via MAP kinases and hypoxia-inducible_factor-1 in HepG2 cells .
2850224	0	insulin-like_growth_factor-1	25,53	somatomedin_C	62,75	insulin-like growth factor-1	somatomedin C	3479	3479	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Studies on the roles of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- / somatomedin_C -LRB- SMC -RRB- during pregnancy -RSB- .
9462692	0	insulin-like_growth_factor-1	50,78	transforming_growth_factor_beta_1	13,46	insulin-like growth factor-1	transforming growth factor beta 1	3479	7040	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of transforming_growth_factor_beta_1 by insulin-like_growth_factor-1 in dermal fibroblasts .
11889017	0	insulin-like_growth_factor-1_and_insulin-like_growth_factor_binding_protein-3	38,115	Tumor_necrosis_factor-alpha	0,27	insulin-like growth factor-1 and insulin-like growth factor binding protein-3	Tumor necrosis factor-alpha	24482;24484	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates insulin-like_growth_factor-1_and_insulin-like_growth_factor_binding_protein-3 expression in vascular smooth muscle .
18337761	0	insulin-like_growth_factor-1_receptor	14,51	HoxA9	0,5	insulin-like growth factor-1 receptor	HoxA9	3480	3205	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	HoxA9 induces insulin-like_growth_factor-1_receptor expression in B-lineage acute_lymphoblastic_leukemia .
19394223	0	insulin-like_growth_factor-1_receptor	86,123	IGF-1R	125,131	insulin-like growth factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Discovery of 3,5-disubstituted-1H-pyrrolo -LSB- 2,3-b -RSB- pyridines as potent inhibitors of the insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- tyrosine kinase .
20178321	0	insulin-like_growth_factor-1_receptor	57,94	IGF-1R	96,102	insulin-like growth factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery and SAR of thiazolidine-2 ,4 - dione analogues as insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitors via hierarchical virtual screening .
21414779	0	insulin-like_growth_factor-1_receptor	50,87	IGF-1R	89,95	insulin-like growth factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of 2,4-bis-arylamino-1 ,3 - pyrimidines as insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitors .
21640718	0	insulin-like_growth_factor-1_receptor	45,82	IGF-1R	84,90	insulin-like growth factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Dual epidermal_growth_factor_receptor -LRB- EGFR -RRB- / insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitor : a novel approach for overcoming resistance in anticancer treatment .
23373648	0	insulin-like_growth_factor-1_receptor	52,89	IGF-1R	91,97	insulin-like growth factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	tyrosine|amod|START_ENTITY tyrosine|appos|END_ENTITY	Recent advancements in small molecule inhibitors of insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- tyrosine kinase as anticancer agents .
9607000	0	insulin-like_growth_factor-1_receptor	18,55	IGF-1R	57,63	insulin-like growth factor-1 receptor	IGF-1R	3480	3480	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Downregulation of insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- expression in human T lymphocyte activation .
17442315	0	insulin-like_growth_factor-1_receptor	53,90	IGF1R	92,97	insulin-like growth factor-1 receptor	IGF1R	3480	3480	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the GAA1013 -- > GAG polymorphism of the insulin-like_growth_factor-1_receptor -LRB- IGF1R -RRB- gene with premature_pubarche .
21317933	0	insulin-like_growth_factor-1_receptor	27,64	P-cadherin	0,10	insulin-like growth factor-1 receptor	P-cadherin	16001(Tax:10090)	12560(Tax:10090)	Gene	Gene	cooperates|advcl|START_ENTITY cooperates|nsubj|END_ENTITY	P-cadherin cooperates with insulin-like_growth_factor-1_receptor to promote metastatic signaling of gonadotropin-releasing_hormone in ovarian_cancer via p120_catenin .
21640718	0	insulin-like_growth_factor-1_receptor	45,82	epidermal_growth_factor_receptor	5,37	insulin-like growth factor-1 receptor	epidermal growth factor receptor	3480	1956	Gene	Gene	inhibitor|amod|START_ENTITY /|dobj|inhibitor /|nsubj|END_ENTITY	Dual epidermal_growth_factor_receptor -LRB- EGFR -RRB- / insulin-like_growth_factor-1_receptor -LRB- IGF-1R -RRB- inhibitor : a novel approach for overcoming resistance in anticancer treatment .
15380337	0	insulin-like_growth_factor-2	23,51	IGF-2	53,58	insulin-like growth factor-2	IGF-2	3481	3481	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Aberrant expression of insulin-like_growth_factor-2 -LRB- IGF-2 -RRB- in Philadelphia_chromosome_negative_chronic_myeloproliferative_disorders .
15661221	0	insulin-like_growth_factor-2	5,33	IGF-2	35,40	insulin-like growth factor-2	IGF-2	3481	3481	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	High insulin-like_growth_factor-2 -LRB- IGF-2 -RRB- gene expression is an independent predictor of poor survival for patients with advanced stage serous_epithelial_ovarian_cancer .
9780317	0	insulin-like_growth_factor-I	62,90	BLT-1	141,146	insulin-like growth factor-I	BLT-1	16000(Tax:10090)	16995(Tax:10090)	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Regulation of luteinizing_hormone_receptor gene expression by insulin-like_growth_factor-I in an immortalized murine Leydig tumor cell line -LRB- BLT-1 -RRB- It is postulated that insulin-like_growth_factor-I -LRB- IGF-I -RRB- , a 70-amino_acid mitogenic polypeptide , regulates Leydig cell steroidogenesis .
1693321	0	insulin-like_growth_factor-I	107,135	BP-28	76,81	insulin-like growth factor-I	BP-28	3479	474268	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The growth hormone independent insulin-like_growth_factor-I binding protein BP-28 is associated with serum insulin-like_growth_factor-I inhibitory bioactivity in adolescent insulin-dependent diabetics .
1385099	0	insulin-like_growth_factor-I	41,69	Basic_fibroblast_growth_factor	0,30	insulin-like growth factor-I	Basic fibroblast growth factor	3479	2247	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor modulates insulin-like_growth_factor-I , its receptor , and its binding proteins in hypothalamic cell cultures .
8247018	0	insulin-like_growth_factor-I	84,112	Basic_fibroblast_growth_factor	0,30	insulin-like growth factor-I	Basic fibroblast growth factor	3479	2247	Gene	Gene	receptor|amod|START_ENTITY overexpressing|dobj|receptor cells|acl|overexpressing stimulates|nmod|cells stimulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor stimulates DNA synthesis in cells overexpressing the insulin-like_growth_factor-I receptor .
9397941	0	insulin-like_growth_factor-I	98,126	Basic_fibroblast_growth_factor	0,30	insulin-like growth factor-I	Basic fibroblast growth factor	24482(Tax:10116)	54250(Tax:10116)	Gene	Gene	presence|nmod|START_ENTITY expression|nmod|presence luteinizing|dobj|expression induces|xcomp|luteinizing induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces luteinizing hormone receptor expression in the presence of insulin-like_growth_factor-I in ovarian granulosa cells .
10556786	0	insulin-like_growth_factor-I	73,101	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	443318(Tax:9940)	443329(Tax:9940)	Gene	Gene	production|amod|START_ENTITY control|dobj|production interact|xcomp|control supply|amod|interact supply|amod|END_ENTITY	Growth_hormone and amino_acid supply interact synergistically to control insulin-like_growth_factor-I production and gene expression in cultured ovine hepatocytes .
1360928	0	insulin-like_growth_factor-I	58,86	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	receptor|appos|START_ENTITY stimulate|dobj|receptor stimulate|nsubj|END_ENTITY	Growth_hormone and prolactin stimulate androgen receptor , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-I_receptor levels in the prostate of immature rats .
2918262	0	insulin-like_growth_factor-I	38,66	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY level|nmod|mRNA regulates|dobj|level regulates|nsubj|END_ENTITY	Growth_hormone regulates the level of insulin-like_growth_factor-I mRNA in rat skeletal muscle .
7528707	0	insulin-like_growth_factor-I	31,59	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- stimulates insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein _ -LRB- IGFBP -RRB- -2 gene expression in spleens of juvenile rats .
8070383	0	insulin-like_growth_factor-I	86,114	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	100008668(Tax:9986)	100356068(Tax:9986)	Gene	Gene	production|nmod|START_ENTITY stimulating|dobj|production stimulates|advcl|stimulating stimulates|nsubj|END_ENTITY	Growth_hormone stimulates follicular development by stimulating ovarian production of insulin-like_growth_factor-I .
8173015	0	insulin-like_growth_factor-I	16,44	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	3479	2688	Gene	Gene	neonates|nsubj|START_ENTITY neonates|advmod|END_ENTITY	Growth_hormone , insulin-like_growth_factor-I and prolactin in small for gestational age neonates .
8550769	0	insulin-like_growth_factor-I	159,187	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	3479	2688	Gene	Gene	induce|dobj|START_ENTITY secretory|parataxis|induce secretory|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- secretory dynamics in a case of acromegalic_gigantism associated with hyperprolactinemia : nonpulsatile secretion of GH may induce elevated insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-3 levels .
9283129	0	insulin-like_growth_factor-I	35,63	Growth_hormone	0,14	insulin-like growth factor-I	Growth hormone	3479	2688	Gene	Gene	START_ENTITY|nsubj|secretion secretion|compound|END_ENTITY	Growth_hormone secretion and serum insulin-like_growth_factor-I concentration in X-linked_hypophosphatemic_rickets before and after treatment .
10502457	0	insulin-like_growth_factor-I	61,89	IGF-I	91,96	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
10583308	0	insulin-like_growth_factor-I	4,32	IGF-I	34,39	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene in individuals born small for gestational age -LRB- SGA -RRB- .
10870582	0	insulin-like_growth_factor-I	44,72	IGF-I	74,79	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The beneficial effects of recombinant human insulin-like_growth_factor-I -LRB- IGF-I -RRB- on wound healing in severely wounded senescent mice .
11587544	0	insulin-like_growth_factor-I	33,61	IGF-I	63,68	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Local and systemic expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNAs in rat after bone_marrow_ablation .
11706070	0	insulin-like_growth_factor-I	14,42	IGF-I	44,49	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in aneurysmal_bone_cyst .
12800944	0	insulin-like_growth_factor-I	65,93	IGF-I	95,100	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene .
12828091	0	insulin-like_growth_factor-I	24,52	IGF-I	54,59	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in patients with liver_cirrhosis .
1377618	0	insulin-like_growth_factor-I	24,52	IGF-I	151,156	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of exogenous insulin-like_growth_factor-I -LRB- IGF-I -RRB- on the reproductive performance of female rats , and on serum concentrations of endogenous IGF-I and IGF-I binding proteins .
15141010	0	insulin-like_growth_factor-I	4,32	IGF-I	34,39	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptor kinase inhibitor NVP-ADW742 , in combination with STI571 , delineates a spectrum of dependence of small_cell_lung_cancer on IGF-I and stem_cell_factor signaling .
15464297	0	insulin-like_growth_factor-I	19,47	IGF-I	49,54	insulin-like growth factor-I	IGF-I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Trophic effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in the inner ear .
15745444	0	insulin-like_growth_factor-I	23,51	IGF-I	53,58	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Antioxidant effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in rats with advanced liver cirrhosis .
16219982	0	insulin-like_growth_factor-I	47,75	IGF-I	77,82	insulin-like growth factor-I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Organ-specific and age-dependent expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA variants : IGF-IA and IB mRNAs in the mouse .
16298440	0	insulin-like_growth_factor-I	34,62	IGF-I	64,69	insulin-like growth factor-I	IGF-I	100305062(Tax:7998)	100305062(Tax:7998)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene in channel_catfish -LRB- Ictalurus_punctatus -RRB- .
16527837	0	insulin-like_growth_factor-I	26,54	IGF-I	56,61	insulin-like growth factor-I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Genetic increase in serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- in C3H/HeJ compared with C57BL/6J mice is associated with increased transcription from the IGF-I exon 2 promoter .
1665320	0	insulin-like_growth_factor-I	76,104	IGF-I	106,111	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Effect of paraformaldehyde fixation on localization and characterization of insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors in the rat brain .
17108398	0	insulin-like_growth_factor-I	29,57	IGF-I	59,64	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic association study of insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene with curve severity and osteopenia in adolescent_idiopathic_scoliosis .
1715381	0	insulin-like_growth_factor-I	15,43	IGF-I	45,50	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I , a potent IGF analogue , on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells .
1715381	0	insulin-like_growth_factor-I	15,43	IGF-I	72,77	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I , a potent IGF analogue , on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells .
17668352	0	insulin-like_growth_factor-I	24,52	IGF-I	54,59	insulin-like growth factor-I	IGF-I	104978413	104978413	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Autocrine production of insulin-like_growth_factor-I -LRB- IGF-I -RRB- affects paracellular transport across epithelial cells in vitro .
18515085	0	insulin-like_growth_factor-I	103,131	IGF-I	133,138	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Adiponectin and resistin are associated with risk for myelodysplastic_syndrome , independently from the insulin-like_growth_factor-I -LRB- IGF-I -RRB- system .
18703307	0	insulin-like_growth_factor-I	22,50	IGF-I	52,57	insulin-like growth factor-I	IGF-I	104978413	104978413	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of endocrine insulin-like_growth_factor-I -LRB- IGF-I -RRB- in female bovine reproduction .
1883485	0	insulin-like_growth_factor-I	76,104	IGF-I	145,150	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression , purification and characterization of secreted recombinant human insulin-like_growth_factor-I -LRB- IGF-I -RRB- and the potent variant des -LRB- 1-3 -RRB- IGF-I in Chinese_hamster ovary cells .
1919400	0	insulin-like_growth_factor-I	32,60	IGF-I	62,67	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Reduced serum concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- in protein-restricted growing rats are accompanied by reduced IGF-I mRNA levels in liver and skeletal muscle .
22166091	0	insulin-like_growth_factor-I	22,50	IGF-I	52,57	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- correlate with disease status in leprosy .
22626778	0	insulin-like_growth_factor-I	43,71	IGF-I	73,78	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of dietary energy on seminal plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- , serum IGF-I and testosterone levels , semen quality and fertility in adult rams .
22626778	0	insulin-like_growth_factor-I	43,71	IGF-I	87,92	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of dietary energy on seminal plasma insulin-like_growth_factor-I -LRB- IGF-I -RRB- , serum IGF-I and testosterone levels , semen quality and fertility in adult rams .
22673406	0	insulin-like_growth_factor-I	61,89	IGF-I	91,96	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Standardized centile curves and reference intervals of serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels in a normal Japanese population using the LMS method .
2549312	0	insulin-like_growth_factor-I	42,70	IGF-I	72,77	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Receptor autoradiographic localization of insulin-like_growth_factor-I -LRB- IGF-I -RRB- binding sites in human fetal and adult adrenal glands .
2558803	0	insulin-like_growth_factor-I	38,66	IGF-I	68,73	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Receptor autoradiographic analysis of insulin-like_growth_factor-I -LRB- IGF-I -RRB- binding sites in rat forebrain and pituitary gland .
2764927	0	insulin-like_growth_factor-I	28,56	IGF-I	58,63	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression and stability of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA splicing variants in the GH3 rat pituitary cell line .
2967888	0	insulin-like_growth_factor-I	29,57	IGF-I	59,64	insulin-like growth factor-I	IGF-I	104978413	104978413	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Bovine chromaffin cells have insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors : IGF-I enhances catecholamine secretion .
7510768	0	insulin-like_growth_factor-I	27,55	IGF-I	57,62	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Effect of fasting on serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels and IGF-I-binding activity in cockerels .
7689959	0	insulin-like_growth_factor-I	16,44	IGF-I	46,51	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Potentiation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- activity by an antibody : supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins .
7765981	0	insulin-like_growth_factor-I	46,74	IGF-I	76,81	insulin-like growth factor-I	IGF-I	100860838	100860838	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Dynamic aspects in the expression of the goat insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene : diversity in transcription and post-transcription .
7772848	0	insulin-like_growth_factor-I	52,80	IGF-I	82,87	insulin-like growth factor-I	IGF-I	100860838	100860838	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Tissue - and development-specific expression of goat insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNAs .
7904496	0	insulin-like_growth_factor-I	24,52	IGF-I	54,59	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	Concentrations|nmod|START_ENTITY Concentrations|appos|END_ENTITY	Concentrations of serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- in normal Chinese children and children with growth_hormone_deficiency .
7958109	0	insulin-like_growth_factor-I	39,67	IGF-I	69,74	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	-LSB- Maternal nutritional states and serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations in normal and abnormal pregnancy -RSB- .
8254297	0	insulin-like_growth_factor-I	20,48	IGF-I	50,55	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- , hepatic growth hormone binding and IGF-I gene expression in the rat during pregnancy and lactation .
8280747	0	insulin-like_growth_factor-I	17,45	IGF-I	47,52	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Acute effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on bone protein synthesis in rats .
8425505	0	insulin-like_growth_factor-I	30,58	IGF-I	60,65	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Distinct promoters in the rat insulin-like_growth_factor-I -LRB- IGF-I -RRB- gene are active in CHO cells .
8606645	0	insulin-like_growth_factor-I	133,161	IGF-I	163,168	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Two weeks of daily injections and continuous infusion of recombinant human growth_hormone -LRB- GH -RRB- in GH-deficient adults : I. Effects on insulin-like_growth_factor-I -LRB- IGF-I -RRB- , GH and IGF binding proteins , and glucose homeostasis .
8669848	0	insulin-like_growth_factor-I	121,149	IGF-I	151,156	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Somatuline -LRB- BIM_23014 -RRB- and tamoxifen treatment of postmenopausal_breast_cancer patients : clinical activity and effect on insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels .
8770611	0	insulin-like_growth_factor-I	68,96	IGF-I	98,103	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Influence of age and fetal hypophysectomy on porcine preadipocytes : insulin-like_growth_factor-I -LRB- IGF-I -RRB- response , receptor binding and IGF binding proteins secretion .
9027409	0	insulin-like_growth_factor-I	16,44	IGF-I	46,51	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Localisation|nmod|START_ENTITY Localisation|appos|END_ENTITY	Localisation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- immunoreactivity in the olivocerebellar system of developing and adult rats .
9030517	0	insulin-like_growth_factor-I	27,55	IGF-I	92,97	insulin-like growth factor-I	IGF-I	3479	3479	Gene	Gene	regulation|nmod|START_ENTITY _|nsubj|regulation _|nmod|END_ENTITY	Differential regulation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ receptor gene expression by IGF-I and basic fibroblastic growth factor .
9200562	0	insulin-like_growth_factor-I	38,66	IGF-I	68,73	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LRB- - -RRB- - Deprenyl treatment restores serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- levels in aged rats to young rat level .
9361347	0	insulin-like_growth_factor-I	31,59	IGF-I	61,66	insulin-like growth factor-I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Cytokines block the effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on glucose uptake and lactate production in skeletal muscle but do not influence IGF-I-induced changes in protein turnover .
9568376	0	insulin-like_growth_factor-I	14,42	IGF-I	44,49	insulin-like growth factor-I	IGF-I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of insulin-like_growth_factor-I -LRB- IGF-I -RRB- on protein turnover in the meat-type chicken -LRB- Gallus_domesticus -RRB- .
1649393	0	insulin-like_growth_factor-I	37,65	IGF-II	142,148	insulin-like growth factor-I	IGF-II	3479	3481	Gene	Gene	down-regulation|nmod|START_ENTITY induce|dobj|down-regulation Progestins|dep|induce Progestins|dep|role role|nmod|END_ENTITY	Progestins induce down-regulation of insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors in human breast_cancer cells : potential autocrine role of IGF-II .
1715381	0	insulin-like_growth_factor-I	15,43	IGF-II	53,59	insulin-like growth factor-I	IGF-II	24482(Tax:10116)	24483(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|IGF-I IGF-I|compound|END_ENTITY	The effects of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I , a potent IGF analogue , on growth hormone and IGF-binding protein secretion from cultured rat anterior pituitary cells .
2005410	0	insulin-like_growth_factor-I	53,81	IGF-II	91,97	insulin-like growth factor-I	IGF-II	24482(Tax:10116)	24483(Tax:10116)	Gene	Gene	clearance|nmod|START_ENTITY IGF-I|nsubj|clearance IGF-I|nsubj|END_ENTITY	Plasma clearance and tissue distribution of labelled insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-II and des -LRB- 1-3 -RRB- IGF-I in rats .
2172801	0	insulin-like_growth_factor-I	20,48	IGF-II	137,143	insulin-like growth factor-I	IGF-II	24482(Tax:10116)	24483(Tax:10116)	Gene	Gene	pattern|nmod|START_ENTITY pattern|dep|comparison comparison|nmod|expression expression|amod|END_ENTITY	Cellular pattern of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and type I IGF receptor gene expression in early organogenesis : comparison with IGF-II gene expression .
8077342	0	insulin-like_growth_factor-I	14,42	IGF-II	77,83	insulin-like growth factor-I	IGF-II	3479	3481	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-II and the IGF-I , IGF-II , and insulin_receptor genes and localization of the gene products in the human ovary .
8188767	0	insulin-like_growth_factor-I	47,75	IGF-II	226,232	insulin-like growth factor-I	IGF-II	3479	3481	Gene	Gene	/|nsubj|START_ENTITY /|dep|stimulation stimulation|nmod|END_ENTITY	Human_osteosarcoma -LRB- U-2_OS -RRB- cells express both insulin-like_growth_factor-I -LRB- IGF-I -RRB- receptors and insulin-like_growth_factor-II / mannose-6-phosphate -LRB- IGF-II/M6P -RRB- receptors and synthesize IGF-II : autocrine growth stimulation by IGF-II via the IGF-I_receptor .
21075859	0	insulin-like_growth_factor-I	54,82	IGF-IR	204,210	insulin-like growth factor-I	IGF-IR	3479	3480	Gene	Gene	START_ENTITY|acl:relcl|induced induced|nmod|down-regulation down-regulation|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Dopamine , by acting through its D2 receptor , inhibits insulin-like_growth_factor-I -LRB- IGF-I -RRB- - induced gastric_cancer cell proliferation via up-regulation of Kr ppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation .
21782884	0	insulin-like_growth_factor-I	18,46	IGF-IR	57,63	insulin-like growth factor-I	IGF-IR	3479	3480	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Plasma and tissue insulin-like_growth_factor-I receptor -LRB- IGF-IR -RRB- as a prognostic marker for prostate_cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases : a review .
7776981	0	insulin-like_growth_factor-I	37,65	Interferon-gamma	0,16	insulin-like growth factor-I	Interferon-gamma	3479	3458	Gene	Gene	synthesis|compound|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits macrophage insulin-like_growth_factor-I synthesis at the transcriptional level .
14967939	0	insulin-like_growth_factor-I	34,62	Oxytocin	0,8	insulin-like growth factor-I	Oxytocin	3479	5020	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Oxytocin mediates some effects of insulin-like_growth_factor-I on porcine ovarian follicles .
2759029	0	insulin-like_growth_factor-I	42,70	Parathyroid_hormone	0,19	insulin-like growth factor-I	Parathyroid hormone	16000(Tax:10090)	19226(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Parathyroid_hormone stimulates release of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-II from neonatal mouse calvaria in organ culture .
19795384	0	insulin-like_growth_factor-I	23,51	REDD1	14,19	insulin-like growth factor-I	REDD1	3479	54541	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of REDD1 by insulin-like_growth_factor-I in skeletal muscle and myotubes .
12682066	0	insulin-like_growth_factor-I	17,45	Stat5b	91,97	insulin-like growth factor-I	Stat5b	16000(Tax:10090)	20851(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY control|nmod|gene transcription|nsubj|control transcription|nmod|END_ENTITY	Acute control of insulin-like_growth_factor-I gene transcription by growth_hormone through Stat5b .
14500651	0	insulin-like_growth_factor-I	24,52	Th2	71,74	insulin-like growth factor-I	Th2	16000(Tax:10090)	15111(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of macrophage insulin-like_growth_factor-I expression by the Th2 cytokines IL-4 and IL-13 .
18507013	0	insulin-like_growth_factor-I	102,130	Transforming_growth_factor-beta1	0,32	insulin-like growth factor-I	Transforming growth factor-beta1	3479	7040	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 modulates tumor-stromal_cell_interactions_of_prostate_cancer through insulin-like_growth_factor-I .
21839662	0	insulin-like_growth_factor-I	6,34	adiponectin	71,82	insulin-like growth factor-I	adiponectin	3479	9370	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Serum insulin-like_growth_factor-I is negatively associated with serum adiponectin in type 2 diabetes_mellitus .
17033713	0	insulin-like_growth_factor-I	72,100	cartilage_oligomeric_matrix_protein	17,52	insulin-like growth factor-I	cartilage oligomeric matrix protein	3479	1311	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of cartilage_oligomeric_matrix_protein gene expression by insulin-like_growth_factor-I revealed by real-time reverse transcription-polymerase chain reaction .
10502457	0	insulin-like_growth_factor-I	61,89	growth_hormone	28,42	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY induction|nmod|mRNA END_ENTITY|dep|induction	Dexamethasone inhibits both growth_hormone -LRB- GH -RRB- - induction of insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA and GH_receptor -LRB- GHR -RRB- mRNA levels in rat primary cultured hepatocytes .
10853714	0	insulin-like_growth_factor-I	51,79	growth_hormone	101,115	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|children children|nmod|deletions deletions|amod|END_ENTITY	Lack of reduction in body fat after treatment with insulin-like_growth_factor-I in two children with growth_hormone gene deletions .
11702667	0	insulin-like_growth_factor-I	49,77	growth_hormone	34,48	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	axis|amod|START_ENTITY study|dep|axis study|nmod|END_ENTITY	-LSB- Clinical study on the changes of growth_hormone / insulin-like_growth_factor-I axis in patient with obstructive_jaundice -RSB- .
12682066	0	insulin-like_growth_factor-I	17,45	growth_hormone	68,82	insulin-like growth factor-I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY control|nmod|gene transcription|nsubj|control transcription|nmod|END_ENTITY	Acute control of insulin-like_growth_factor-I gene transcription by growth_hormone through Stat5b .
12793602	0	insulin-like_growth_factor-I	11,39	growth_hormone	144,158	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	deficiency|amod|START_ENTITY Effects|nmod|deficiency Effects|nmod|system system|nmod|patients patients|nmod|Laron_syndrome Laron_syndrome|appos|insensitivity insensitivity|amod|END_ENTITY	Effects of insulin-like_growth_factor-I deficiency and replacement therapy on the hematopoietic system in patients with Laron_syndrome -LRB- primary growth_hormone insensitivity -RRB- .
1474468	0	insulin-like_growth_factor-I	14,42	growth_hormone	53,67	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of insulin-like_growth_factor-I and human growth_hormone on periodontal ligament fibroblast morphology , growth pattern , DNA synthesis , and receptor binding .
14960017	0	insulin-like_growth_factor-I	47,75	growth_hormone	31,45	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Basal and stimulated levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-I binding and IGF-binding proteins in beta-thalassemia major .
15063105	0	insulin-like_growth_factor-I	72,100	growth_hormone	5,19	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	aging|nmod|START_ENTITY prevent|dobj|aging prevent|nsubj|END_ENTITY	Does growth_hormone prevent aging in the healthy elderly with low serum insulin-like_growth_factor-I ?
15684342	0	insulin-like_growth_factor-I	65,93	growth_hormone	42,56	insulin-like growth factor-I	growth hormone	100327329(Tax:9031)	378781(Tax:9031)	Gene	Gene	modulate|advcl|START_ENTITY modulate|dobj|effect effect|nmod|END_ENTITY	Metabolic hormones modulate the effect of growth_hormone -LRB- GH -RRB- on insulin-like_growth_factor-I -LRB- IGF-I -RRB- mRNA level in primary culture of salmon hepatocytes .
16214911	0	insulin-like_growth_factor-I	85,113	growth_hormone	25,39	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	factor|compound|START_ENTITY circulating|dobj|factor relation|acl|circulating pathway|nmod|relation pathway|amod|END_ENTITY	Genetic variation in the growth_hormone synthesis pathway in relation to circulating insulin-like_growth_factor-I , insulin-like growth factor binding protein-3 , and breast_cancer risk : results from the European prospective investigation into cancer and nutrition study .
1677331	0	insulin-like_growth_factor-I	122,150	growth_hormone	26,40	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effect effect|nmod|prolactin prolactin|compound|END_ENTITY	The stimulatory effect of growth_hormone , prolactin , and placental lactogen on beta-cell proliferation is not mediated by insulin-like_growth_factor-I .
1710624	0	insulin-like_growth_factor-I	71,99	growth_hormone	31,45	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels END_ENTITY|acl|circulating	Short and long term effects of growth_hormone on circulating levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF-binding_protein-1 , and insulin : a placebo-controlled study .
17407215	0	insulin-like_growth_factor-I	99,127	growth_hormone	185,199	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	levels|compound|START_ENTITY improve|dobj|levels improve|nmod|improvement improvement|nmod|response response|amod|END_ENTITY	A combination of 6 months of treatment with pyridostigmine and triweekly exercise fails to improve insulin-like_growth_factor-I levels in fibromyalgia , despite improvement in the acute growth_hormone response to exercise .
18341092	0	insulin-like_growth_factor-I	30,58	growth_hormone	119,133	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	treatment|compound|START_ENTITY length|nmod|treatment length|advcl|treatment treatment|compound|END_ENTITY	Foot length before and during insulin-like_growth_factor-I treatment of children with laron_syndrome compared to human growth_hormone treatment of children with isolated growth_hormone deficiency .
18341092	0	insulin-like_growth_factor-I	30,58	growth_hormone	170,184	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	treatment|compound|START_ENTITY length|nmod|treatment length|advcl|treatment treatment|nmod|children children|nmod|deficiency deficiency|compound|END_ENTITY	Foot length before and during insulin-like_growth_factor-I treatment of children with laron_syndrome compared to human growth_hormone treatment of children with isolated growth_hormone deficiency .
1909610	0	insulin-like_growth_factor-I	129,157	growth_hormone	40,54	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	levels|nmod|START_ENTITY associated|nmod|levels activity|acl|associated levels|nmod|activity levels|compound|END_ENTITY	Critically_ill patients have high basal growth_hormone levels with attenuated_oscillatory activity associated with low levels of insulin-like_growth_factor-I .
19570739	0	insulin-like_growth_factor-I	4,32	growth_hormone	76,90	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	generation|amod|START_ENTITY test|nsubj|generation test|nmod|indicator indicator|nmod|status status|amod|END_ENTITY	The insulin-like_growth_factor-I -LRB- IGF-I -RRB- generation test as an indicator of growth_hormone status .
20029798	0	insulin-like_growth_factor-I	62,90	growth_hormone	19,33	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	level|amod|START_ENTITY bioactive|dobj|level bioactive|nsubj|optimizes optimizes|amod|END_ENTITY	Sustained low-dose growth_hormone therapy optimizes bioactive insulin-like_growth_factor-I level and may enhance CD4 T-cell number in HIV_infection .
2189886	0	insulin-like_growth_factor-I	127,155	growth_hormone	58,72	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	indices|amod|START_ENTITY circulating|dobj|indices effects|acl|circulating Pulsatile|dep|effects Pulsatile|nmod|administration administration|nmod|END_ENTITY	Pulsatile versus continuous intravenous administration of growth_hormone -LRB- GH -RRB- in GH-deficient patients : effects on circulating insulin-like_growth_factor-I and metabolic indices .
2229302	0	insulin-like_growth_factor-I	36,64	growth_hormone	215,229	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	changes|nmod|START_ENTITY study|nmod|changes treated|nsubj|study treated|nmod|END_ENTITY	Comparative study of the changes in insulin-like_growth_factor-I , procollagen-III N-terminal extension peptide , bone Gla-protein , and bone mineral content in children with Turner 's _ syndrome treated with recombinant growth_hormone .
22511534	0	insulin-like_growth_factor-I	94,122	growth_hormone	221,235	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	concentrations|compound|START_ENTITY stability|nmod|concentrations cycle|nmod|stability effects|nmod|cycle effects|dep|Implications Implications|nmod|detection detection|nmod|misuse misuse|amod|END_ENTITY	The effects of a freeze-thaw cycle and pre-analytical storage temperature on the stability of insulin-like_growth_factor-I and pro-collagen type III N-terminal propeptide concentrations : Implications for the detection of growth_hormone misuse in athletes .
22524398	0	insulin-like_growth_factor-I	38,66	growth_hormone	23,37	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	axis|amod|START_ENTITY usefulness|dep|axis usefulness|nmod|END_ENTITY	Possible usefulness of growth_hormone / insulin-like_growth_factor-I axis in Alzheimer 's _ disease treatment .
23980167	0	insulin-like_growth_factor-I	57,85	growth_hormone	41,55	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	axis|amod|START_ENTITY response|dep|axis response|nmod|END_ENTITY	SIRT1 regulates adaptive response of the growth_hormone -- insulin-like_growth_factor-I axis under fasting conditions in liver .
2769164	0	insulin-like_growth_factor-I	68,96	growth_hormone	123,137	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	growth|nmod|START_ENTITY Inhibition|nmod|growth Inhibition|acl|using using|dobj|antiserum antiserum|acl|rat rat|dobj|END_ENTITY	Inhibition of neonatal rat growth and circulating concentrations of insulin-like_growth_factor-I using an antiserum to rat growth_hormone .
3289898	1	insulin-like_growth_factor-I	56,84	growth_hormone	101,115	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|concentrations concentrations|compound|END_ENTITY	The effect of insulin-like_growth_factor-I on plasma fetal growth_hormone , insulin and glucose concentrations .
3359980	0	insulin-like_growth_factor-I	24,52	growth_hormone	148,162	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY Regulation|nmod|levels Regulation|dep|implications implications|nmod|autoregulation autoregulation|amod|END_ENTITY	Regulation of pituitary insulin-like_growth_factor-I messenger ribonucleic_acid levels in rats harboring somatomammotropic tumors : implications for growth_hormone autoregulation .
7476303	0	insulin-like_growth_factor-I	96,124	growth_hormone	35,49	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	treatment|compound|START_ENTITY Carbohydrate|nmod|treatment Carbohydrate|dobj|metabolism metabolism|nmod|resistance resistance|compound|END_ENTITY	Carbohydrate metabolism in primary growth_hormone resistance -LRB- Laron_syndrome -RRB- before and during insulin-like_growth_factor-I treatment .
7513341	0	insulin-like_growth_factor-I	8,36	growth_hormone	180,194	insulin-like growth factor-I	growth hormone	3479	81668(Tax:10116)	Gene	Gene	analogues|compound|START_ENTITY analogues|dep|protein-3 protein-3|acl:relcl|fail fail|xcomp|mimic mimic|dobj|effect effect|nmod|END_ENTITY	Several insulin-like_growth_factor-I analogues and complexes_of_insulin-like_growth_factors-I_and _ - II_with_insulin-like_growth factor-binding protein-3 fail to mimic the effect of growth_hormone upon lactation in the rat .
7513345	0	insulin-like_growth_factor-I	45,73	growth_hormone	10,24	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	steroidogenesis|appos|START_ENTITY END_ENTITY|nmod|steroidogenesis	Effect of growth_hormone on steroidogenesis , insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF-binding_protein-1 production and DNA synthesis in cultured human luteinized granulosa cells .
7524925	0	insulin-like_growth_factor-I	19,47	growth_hormone	124,138	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	Comparison|nmod|START_ENTITY measurement|nsubj|Comparison measurement|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Comparison between insulin-like_growth_factor-I -LRB- IGF-I -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- measurement in the diagnosis of growth_hormone deficiency .
7691864	0	insulin-like_growth_factor-I	26,54	growth_hormone	10,24	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	_|nsubj|START_ENTITY _|nsubj|Levels Levels|nmod|END_ENTITY	Levels of growth_hormone , insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ and _ - II , _ IGF-binding_protein-1_and _ -3 , and cortisol in prednisone-treated children with growth_retardation after renal transplantation .
7720672	0	insulin-like_growth_factor-I	24,52	growth_hormone	75,89	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|acl|transcription transcription|nmod|END_ENTITY	Rapid activation of rat insulin-like_growth_factor-I gene transcription by growth_hormone reveals no changes in deoxyribonucleic acid-protein interactions within the second promoter .
7799357	0	insulin-like_growth_factor-I	99,127	growth_hormone	129,143	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	insulin|appos|START_ENTITY END_ENTITY|nsubj|insulin	Growth promoting peptides in osteoarthritis and diffuse_idiopathic_skeletal_hyperostosis -- insulin , insulin-like_growth_factor-I , growth_hormone .
7925121	0	insulin-like_growth_factor-I	24,52	growth_hormone	75,89	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|acl|transcription transcription|nmod|END_ENTITY	Rapid activation of rat insulin-like_growth_factor-I gene transcription by growth_hormone reveals no alterations in deoxyribonucleic acid-protein interactions within the major promoter .
8254284	0	insulin-like_growth_factor-I	112,140	growth_hormone	21,35	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	composition|nmod|START_ENTITY Interactions|dep|composition Interactions|nmod|END_ENTITY	Interactions between growth_hormone and nutrition in hypophysectomized rats : body composition and production of insulin-like_growth_factor-I .
8632230	0	insulin-like_growth_factor-I	110,138	growth_hormone	75,89	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	concentrations|compound|START_ENTITY abolishes|dobj|concentrations abolishes|nmod|END_ENTITY	Moderate food restriction abolishes the pregnancy-associated rise in serum growth_hormone and decreases serum insulin-like_growth_factor-I -LRB- IGF-I -RRB- concentrations without altering IGF-I mRNA expression in rats .
8788308	0	insulin-like_growth_factor-I	15,43	growth_hormone	104,118	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	release|nmod|START_ENTITY release|dep|regulation regulation|nmod|steroids steroids|compound|END_ENTITY	The release of insulin-like_growth_factor-I by luteinized human granulosa cells in vitro : regulation by growth_hormone , oxytocin , steroids and cAMP-dependent intracellular mechanisms .
8816035	0	insulin-like_growth_factor-I	77,105	growth_hormone	19,33	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	response|dep|START_ENTITY response|amod|END_ENTITY	Growth parameters , growth_hormone -LRB- GH -RRB- response to clonidine and circulating insulin-like_growth_factor-I -LRB- IGF-I -RRB- , free thyroxine -LRB- FT4 -RRB- and cortisol concentrations in relation to glycaemic control in children with insulin-dependent_diabetes_mellitus .
9041052	0	insulin-like_growth_factor-I	77,105	growth_hormone	163,177	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	alkaline|nmod|START_ENTITY alkaline|nmod|adults adults|nmod|deficiency deficiency|amod|END_ENTITY	Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like_growth_factor-I -LRB- IGF-I -RRB- and during growth_hormone therapy in adults with growth_hormone deficiency .
9096605	0	insulin-like_growth_factor-I	30,58	growth_hormone	11,25	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	singly|advmod|START_ENTITY singly|dep|END_ENTITY	Effects of growth_hormone and insulin-like_growth_factor-I singly and in combination on in vivo capacity of urea synthesis , gene expression of urea cycle enzymes , and organ nitrogen contents in rats .
9225125	0	insulin-like_growth_factor-I	119,147	growth_hormone	26,40	insulin-like growth factor-I	growth hormone	100327329(Tax:9031)	378781(Tax:9031)	Gene	Gene	concentrations|nmod|START_ENTITY circulating|dobj|concentrations exerts|advcl|circulating exerts|nsubj|administration administration|nmod|END_ENTITY	Chronic administration of growth_hormone -LRB- GH -RRB- to adult chickens exerts marked effects on circulating concentrations of insulin-like_growth_factor-I -LRB- IGF-I -RRB- , IGF binding proteins , hepatic GH regulated gene I , and hepatic GH_receptor mRNA .
9231798	0	insulin-like_growth_factor-I	115,143	growth_hormone	14,28	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of growth_hormone -LRB- GH -RRB- gene expression and secretion during pregnancy and lactation in the rat : role of insulin-like_growth_factor-I , somatostatin , and GH-releasing_hormone .
9555872	0	insulin-like_growth_factor-I	89,117	growth_hormone	74,88	insulin-like growth factor-I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	Alcohol withdrawal-induced change in lipoprotein -LRB- a -RRB- : association with the growth_hormone / insulin-like_growth_factor-I -LRB- IGF-I -RRB- / IGF-binding_protein-1 -LRB- IGFBP-1 -RRB- axis .
9886844	0	insulin-like_growth_factor-I	47,75	growth_hormone	79,93	insulin-like growth factor-I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Molecular mechanisms of the negative effect of insulin-like_growth_factor-I on growth_hormone gene expression in MtT/S somatotroph cells .
10624798	0	insulin-like_growth_factor-I	10,38	growth_hormone-releasing_factor_receptor	42,82	insulin-like growth factor-I	growth hormone-releasing factor receptor	24482(Tax:10116)	25321(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of insulin-like_growth_factor-I on growth_hormone-releasing_factor_receptor expression in primary rat anterior pituitary cell culture .
14585811	0	insulin-like_growth_factor-I	35,63	igf-I	65,70	insulin-like growth factor-I	igf-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Development of leydig cells in the insulin-like_growth_factor-I -LRB- igf-I -RRB- knockout mouse : effects of igf-I replacement and gonadotropic stimulation .
17410466	0	insulin-like_growth_factor-I	24,52	igf-I	54,59	insulin-like growth factor-I	igf-I	3479	3479	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of insulin-like_growth_factor-I -LRB- igf-I -RRB- as a marker of liver_fibrosis in patients with chronic hepatitis_C .
23599716	0	insulin-like_growth_factor-I	32,60	igf-I	62,67	insulin-like growth factor-I	igf-I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	A survey of correlation between insulin-like_growth_factor-I -LRB- igf-I -RRB- levels and severity of liver_cirrhosis .
19258508	0	insulin-like_growth_factor-I	87,115	insulin-like_growth_factor_binding_protein-3	31,75	insulin-like growth factor-I	insulin-like growth factor binding protein-3	3479	3486	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	NKX3 .1 activates expression of insulin-like_growth_factor_binding_protein-3 to mediate insulin-like_growth_factor-I signaling and cell proliferation .
20642578	0	insulin-like_growth_factor-I	13,41	interleukin-17F	45,60	insulin-like growth factor-I	interleukin-17F	3479	112744	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of insulin-like_growth_factor-I by interleukin-17F in bronchial epithelial cells .
15195991	0	insulin-like_growth_factor-I	16,44	interleukin-6	133,146	insulin-like growth factor-I	interleukin-6	3479	3569	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Serum levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- , and their relationships with serum interleukin-6 , in the geriatric syndrome of frailty .
9780317	0	insulin-like_growth_factor-I	62,90	luteinizing_hormone_receptor	14,42	insulin-like growth factor-I	luteinizing hormone receptor	16000(Tax:10090)	16867(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of luteinizing_hormone_receptor gene expression by insulin-like_growth_factor-I in an immortalized murine Leydig tumor cell line -LRB- BLT-1 -RRB- It is postulated that insulin-like_growth_factor-I -LRB- IGF-I -RRB- , a 70-amino_acid mitogenic polypeptide , regulates Leydig cell steroidogenesis .
10328964	0	insulin-like_growth_factor-I	90,118	myogenin	141,149	insulin-like growth factor-I	myogenin	16000(Tax:10090)	17928(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Tumor_necrosis_factor-alpha and basic_fibroblast_growth_factor differentially inhibit the insulin-like_growth_factor-I induced expression of myogenin in C2C12 myoblasts .
9492043	0	insulin-like_growth_factor-I	14,42	p53	164,167	insulin-like growth factor-I	p53	3479	7157	Gene	Gene	START_ENTITY|dep|interaction interaction|nmod|END_ENTITY	p53 regulates insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line : interaction between p53 and Sp1 .
18922796	0	insulin-like_growth_factor-I	23,51	p65	121,124	insulin-like growth factor-I	p65	24482(Tax:10116)	25716(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Stimulatory effects of insulin-like_growth_factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65 .
16452250	0	insulin-like_growth_factor-I	104,132	p70S6_kinase	78,90	insulin-like growth factor-I	p70S6 kinase	16000(Tax:10090)	72508(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Thiazolidinediones inhibit insulin-like_growth_factor-i-induced activation of p70S6_kinase and suppress insulin-like_growth_factor-I tumor-promoting activity .
14744750	0	insulin-like_growth_factor-I	6,34	prostate-specific_antigen	71,96	insulin-like growth factor-I	prostate-specific antigen	3479	354	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Serum insulin-like_growth_factor-I is positively associated with serum prostate-specific_antigen in middle-aged men without evidence of prostate_cancer .
6749882	0	insulin-like_growth_factor-I	23,51	somatomedin-C	52,65	insulin-like growth factor-I	somatomedin-C	3479	3479	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|END_ENTITY	Characterization of an insulin-like_growth_factor-I / somatomedin-C radioimmunoassay specific for the C-peptide region .
8895324	0	insulin-like_growth_factor-I	29,57	tumor_necrosis_factor-alpha	85,112	insulin-like growth factor-I	tumor necrosis factor-alpha	3479	7124	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Direct stimulatory effect of insulin-like_growth_factor-I on monocyte and macrophage tumor_necrosis_factor-alpha production .
10585594	0	insulin-like_growth_factor-I	63,91	vascular_endothelial_growth_factor	14,48	insulin-like growth factor-I	vascular endothelial growth factor	3479	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by insulin-like_growth_factor-I in endometrial_adenocarcinoma cells .
18677403	0	insulin-like_growth_factor-I	14,42	vascular_endothelial_growth_factor	79,113	insulin-like growth factor-I	vascular endothelial growth factor	397491(Tax:9823)	397157(Tax:9823)	Gene	Gene	hormone|compound|START_ENTITY hormone|nmod|END_ENTITY	The effect of insulin-like_growth_factor-I , relaxin and luteinizing hormone on vascular_endothelial_growth_factor secretion by cultured endometrial stromal cells on different days of early pregnancy in pigs .
12960026	0	insulin-like_growth_factor-II	20,49	CTCF	0,4	insulin-like growth factor-II	CTCF	3481	10664	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	CTCF binding at the insulin-like_growth_factor-II -LRB- IGF2 -RRB- / H19 imprinting control region is insufficient to regulate IGF2/H19 expression in human tissues .
22726701	0	insulin-like_growth_factor-II	18,47	IGF-II	10,16	insulin-like growth factor-II	IGF-II	3481	3481	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of IGF-II -LRB- insulin-like_growth_factor-II -RRB- genotype on the quality of dry-cured hams and shoulders .
11717330	0	insulin-like_growth_factor-II	22,51	IGF2	53,57	insulin-like growth factor-II	IGF2	3481	3481	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Loss of imprinting of insulin-like_growth_factor-II -LRB- IGF2 -RRB- gene in distinguishing specific biologic subtypes of Wilms_tumor .
19192721	0	insulin-like_growth_factor-II_mRNA_binding_protein_3	14,66	IMP3	68,72	insulin-like growth factor-II mRNA binding protein 3	IMP3	55272	55272	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor-II_mRNA_binding_protein_3 -LRB- IMP3 -RRB- in osteosarcoma .
10026153	0	insulin-like_growth_factor-I_receptor	56,93	C-terminal_Src_kinase	0,21	insulin-like growth factor-I receptor	C-terminal Src kinase	16001(Tax:10090)	12988(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	C-terminal_Src_kinase associates with ligand-stimulated insulin-like_growth_factor-I_receptor .
10760788	0	insulin-like_growth_factor-I_receptor	4,41	CD28	58,62	insulin-like growth factor-I receptor	CD28	3480	940	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The insulin-like_growth_factor-I_receptor is regulated by CD28 and protects activated T cells from apoptosis .
16730884	0	insulin-like_growth_factor-I_receptor	109,146	IGF-IR	148,154	insulin-like growth factor-I receptor	IGF-IR	3480	3480	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel EWS-WT1 gene fusion product in desmoplastic_small_round_cell_tumor is a potent transactivator of the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- gene .
16968249	0	insulin-like_growth_factor-I_receptor	36,73	IGF-IR	75,81	insulin-like growth factor-I receptor	IGF-IR	25718(Tax:10116)	25718(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- in the developing and mature rat testes .
17766039	0	insulin-like_growth_factor-I_receptor	9,46	IGF-IR	48,54	insulin-like growth factor-I receptor	IGF-IR	3480	3480	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Elevated insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- levels in primary breast_tumors associated with BRCA1 mutations .
17950526	0	insulin-like_growth_factor-I_receptor	93,130	IGF-IR	132,138	insulin-like growth factor-I receptor	IGF-IR	3480	3480	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- expression in human pancreatic_carcinoma cells by the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- system .
17983756	0	insulin-like_growth_factor-I_receptor	70,107	IGF-IR	109,115	insulin-like growth factor-I receptor	IGF-IR	3480	3480	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel 2-phenylquinolin-7-yl-derived imidazo -LSB- 1,5-a -RSB- pyrazines as potent insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- inhibitors .
19703789	0	insulin-like_growth_factor-I_receptor	60,97	IGF-IR	99,105	insulin-like growth factor-I receptor	IGF-IR	3480	3480	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcription factor E2F1 is a potent transactivator of the insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- gene .
25980584	0	insulin-like_growth_factor-I_receptor	112,149	IGF-IR	151,157	insulin-like growth factor-I receptor	IGF-IR	3480	3480	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Chimaphilin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines through insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- signaling .
20116405	0	insulin-like_growth_factor-I_receptor	66,103	RICTOR	15,21	insulin-like growth factor-I receptor	mTORC1	3480	382056(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- and human epidermal_growth_factor_receptor-2 -LRB- Her2 -RRB- expression in gastrointestinal_cancer cells .
20116405	0	insulin-like_growth_factor-I_receptor	66,103	mTOR	29,33	insulin-like growth factor-I receptor	mTOR	3480	21977(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- and human epidermal_growth_factor_receptor-2 -LRB- Her2 -RRB- expression in gastrointestinal_cancer cells .
1380055	0	insulin-like_growth_factor-binding_protein-1	49,93	Epidermal_growth_factor	0,23	insulin-like growth factor-binding protein-1	Epidermal growth factor	3484	1950	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates production of insulin-like_growth_factor-binding_protein-1 in human granulosa-luteal cells .
9542973	0	insulin-like_growth_factor-binding_protein-1	14,58	IGFBP-1	60,67	insulin-like growth factor-binding protein-1	IGFBP-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of insulin-like_growth_factor-binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA in embryos and endometrial stromal cells .
1705656	0	insulin-like_growth_factor-binding_protein-1	34,78	growth_hormone	93,107	insulin-like growth factor-binding protein-1	growth hormone	25685(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcriptional regulation of rat insulin-like_growth_factor-binding_protein-1 expression by growth_hormone .
1379255	0	insulin-like_growth_factor-binding_protein-1	42,86	protein_kinase-C	8,24	insulin-like growth factor-binding protein-1	protein kinase-C	3484	112476	Gene	Gene	production|amod|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of protein_kinase-C in regulation of insulin-like_growth_factor-binding_protein-1 production by HepG2 cells .
15140235	0	insulin-like_growth_factor-binding_protein-3	22,66	IGFBP-3	68,75	insulin-like growth factor-binding protein-3	IGFBP-3	3486	3486	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP-3 -RRB- in Squamous_cell_carcinoma complicating recessive_dystrophic_epidermolysis_bullosa .
21892705	0	insulin-like_growth_factor-binding_protein-3	95,139	IGFBP3	141,147	insulin-like growth factor-binding protein-3	IGFBP3	3486	3486	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Urinary_bladder_cancer risk in relation to a single nucleotide polymorphism -LRB- rs2854744 -RRB- in the insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP3 -RRB- gene .
23464449	0	insulin-like_growth_factor-binding_protein-3	76,120	IGFBP3	122,128	insulin-like growth factor-binding protein-3	IGFBP3	3486	3486	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prostate_cancer risk in relation to a single nucleotide polymorphism in the insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP3 -RRB- gene : a meta-analysis .
25059666	0	insulin-like_growth_factor-binding_protein-3	67,111	MicroRNA-21	0,11	insulin-like growth factor-binding protein-3	MicroRNA-21	3486	406991	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like_growth_factor-binding_protein-3 -LRB- IGFBP3 -RRB- .
24337110	0	insulin-like_growth_factor-binding_protein-3	14,58	sphingosine_kinase-1	77,97	insulin-like growth factor-binding protein-3	sphingosine kinase-1	16009(Tax:10090)	20698(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|END_ENTITY	Inhibition of insulin-like_growth_factor-binding_protein-3 signaling through sphingosine_kinase-1 sensitizes triple-negative_breast_cancer cells to EGF receptor blockade .
15069073	0	insulin-like_growth_factor-binding_protein-3	98,142	transglutaminase_2	73,91	insulin-like growth factor-binding protein-3	transglutaminase 2	3486	7052	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Tissue_transglutaminase has intrinsic kinase activity : identification of transglutaminase_2 as an insulin-like_growth_factor-binding_protein-3 kinase .
7527411	0	insulin-like_growth_factor-binding_protein-4	4,48	IGFBP-4	59,66	insulin-like growth factor-binding protein-4	IGFBP-4	3487	3487	Gene	Gene	START_ENTITY|dep|system system|compound|END_ENTITY	The insulin-like_growth_factor-binding_protein-4 -LRB- IGFBP-4 -RRB- - IGFBP-4 protease system in normal human osteoblast-like cells : regulation by transforming_growth_factor-beta .
7527411	0	insulin-like_growth_factor-binding_protein-4	4,48	transforming_growth_factor-beta	136,167	insulin-like growth factor-binding protein-4	transforming growth factor-beta	3487	7040	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	The insulin-like_growth_factor-binding_protein-4 -LRB- IGFBP-4 -RRB- - IGFBP-4 protease system in normal human osteoblast-like cells : regulation by transforming_growth_factor-beta .
25212428	0	insulin-like_growth_factor-binding_protein-7	21,65	IGFBP7	67,73	insulin-like growth factor-binding protein-7	IGFBP7	289560(Tax:10116)	289560(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of insulin-like_growth_factor-binding_protein-7 -LRB- IGFBP7 -RRB- on in vitro angiogenesis of vascular endothelial cells in the rat corpus luteum .
23397525	0	insulin-like_growth_factor-binding_protein_2	15,59	a2-macroglobulin	65,81	insulin-like growth factor-binding protein 2	a2-macroglobulin	3485	2	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of insulin-like_growth_factor-binding_protein_2 with a2-macroglobulin in the circulation .
15520175	0	insulin-like_growth_factor-binding_protein_3	66,110	Epidermal_growth_factor_receptor	0,32	insulin-like growth factor-binding protein 3	Epidermal growth factor receptor	3486	1956	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Epidermal_growth_factor_receptor regulates aberrant expression of insulin-like_growth_factor-binding_protein_3 .
19897600	0	insulin-like_growth_factor-binding_protein_5	8,52	IGFBP5	54,60	insulin-like growth factor-binding protein 5	IGFBP5	16011(Tax:10090)	16011(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of insulin-like_growth_factor-binding_protein_5 -LRB- IGFBP5 -RRB- in organismal and pancreatic beta-cell growth .
21413833	0	insulin-like_growth_factor-binding_protein_7	27,71	IGFBP7	73,79	insulin-like growth factor-binding protein 7	IGFBP7	3490	3490	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Function and expression of insulin-like_growth_factor-binding_protein_7 -LRB- IGFBP7 -RRB- gene in childhood acute_myeloid_leukemia .
16320338	0	insulin-like_growth_factor_1	65,93	Basic_fibroblast_growth_factor	0,30	insulin-like growth factor 1	Basic fibroblast growth factor	3479	2247	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Basic_fibroblast_growth_factor inhibits the anabolic activity of insulin-like_growth_factor_1 and osteogenic_protein_1 in adult human articular chondrocytes .
14534298	0	insulin-like_growth_factor_1	24,52	Beta-arrestin1	0,14	insulin-like growth factor 1	Beta-arrestin1	16000(Tax:10090)	109689(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Beta-arrestin1 mediates insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- activation of phosphatidylinositol 3-kinase -LRB- PI3K -RRB- and anti-apoptosis .
19546233	0	insulin-like_growth_factor_1	51,79	Cbl-b	17,22	insulin-like growth factor 1	Cbl-b	16000(Tax:10090)	208650(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Ubiquitin_ligase Cbl-b is a negative regulator for insulin-like_growth_factor_1 signaling during muscle_atrophy caused by unloading .
10453940	0	insulin-like_growth_factor_1	15,43	Growth_hormone	0,14	insulin-like growth factor 1	Growth hormone	3479	2688	Gene	Gene	alterations|amod|START_ENTITY contribute|nsubj|alterations END_ENTITY|parataxis|contribute	Growth_hormone / insulin-like_growth_factor_1 axis alterations contribute to disturbed protein metabolism in cirrhosis patients after hepatectomy .
15108263	0	insulin-like_growth_factor_1	15,43	Growth_hormone	0,14	insulin-like growth factor 1	Growth hormone	3479	2688	Gene	Gene	recovery|amod|START_ENTITY recovery|compound|END_ENTITY	Growth_hormone / insulin-like_growth_factor_1 axis recovery after liver transplantation : a preliminary prospective study .
16670201	0	insulin-like_growth_factor_1	67,95	Growth_hormone	0,14	insulin-like growth factor 1	Growth hormone	3479	2688	Gene	Gene	up-regulation|amod|START_ENTITY independent|nmod|up-regulation promotes|dobj|independent promotes|nsubj|END_ENTITY	Growth_hormone promotes skeletal muscle cell fusion independent of insulin-like_growth_factor_1 up-regulation .
24889799	0	insulin-like_growth_factor_1	15,43	Growth_hormone	0,14	insulin-like growth factor 1	Growth hormone	3479	2688	Gene	Gene	dynamics|amod|START_ENTITY transplantation|nsubj|dynamics END_ENTITY|parataxis|transplantation	Growth_hormone / insulin-like_growth_factor_1 dynamics in adult living donor liver transplantation .
10341452	0	insulin-like_growth_factor_1	27,55	IGF-1	57,62	insulin-like growth factor 1	IGF-1	3479	3479	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Stable production of human insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in the milk of hemi - and homozygous transgenic rabbits over several generations .
14534298	0	insulin-like_growth_factor_1	24,52	IGF-1	54,59	insulin-like growth factor 1	IGF-1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Beta-arrestin1 mediates insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- activation of phosphatidylinositol 3-kinase -LRB- PI3K -RRB- and anti-apoptosis .
1640193	0	insulin-like_growth_factor_1	21,49	IGF-1	51,56	insulin-like growth factor 1	IGF-1	3479	3479	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Low plasma levels of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in male patients with idiopathic_osteoporosis .
17354613	0	insulin-like_growth_factor_1	16,44	IGF-1	46,51	insulin-like growth factor 1	IGF-1	3479	3479	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in skeletal muscle physiology .
1851744	0	insulin-like_growth_factor_1	4,32	IGF-1	34,39	insulin-like growth factor 1	IGF-1	378699(Tax:8355)	378699(Tax:8355)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- receptor is responsible for mediating the effects of insulin , IGF-1 , and IGF-2 in Xenopus_laevis oocytes .
18761080	0	insulin-like_growth_factor_1	66,94	IGF-1	96,101	insulin-like growth factor 1	IGF-1	3479	3479	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Absence of association between SNPs in the promoter region of the insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- gene and longevity in the Han Chinese population .
22308338	0	insulin-like_growth_factor_1	56,84	IGF-1	86,91	insulin-like growth factor 1	IGF-1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Light stimuli control neuronal migration by altering of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- signaling .
3962685	0	insulin-like_growth_factor_1	99,127	IGF-1	129,134	insulin-like growth factor 1	IGF-1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The influence of maternal protein deprivation on the developmental pattern of serum immunoreactive insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- levels .
7867698	0	insulin-like_growth_factor_1	14,42	IGF-1	44,49	insulin-like growth factor 1	IGF-1	281239(Tax:9913)	281239(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- in the bovine oviduct during the oestrous cycle .
8408032	0	insulin-like_growth_factor_1	48,76	IGF-1	78,83	insulin-like growth factor 1	IGF-1	3479	3479	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Ethanol inhibits the autophosphorylation of the insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- receptor and IGF-1-mediated proliferation of 3T3 cells .
21471200	0	insulin-like_growth_factor_1	15,43	IGF1	45,49	insulin-like growth factor 1	IGF1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Foxo1 mediates insulin-like_growth_factor_1 -LRB- IGF1 -RRB- / insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts .
22357625	0	insulin-like_growth_factor_1	16,44	IGF1	46,50	insulin-like growth factor 1	IGF1	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mex3c regulates insulin-like_growth_factor_1 -LRB- IGF1 -RRB- expression and promotes postnatal growth .
26059224	0	insulin-like_growth_factor_1	31,59	IGF1	61,65	insulin-like growth factor 1	IGF1	418090(Tax:9031)	418090(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism and expression of insulin-like_growth_factor_1 -LRB- IGF1 -RRB- gene and its association with growth traits in chicken .
19944347	0	insulin-like_growth_factor_1	29,57	IGFBP-3	93,100	insulin-like growth factor 1	IGFBP-3	3479	3486	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Anthropometric correlates of insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- and IGF_binding_protein-3 -LRB- IGFBP-3 -RRB- levels by race/ethnicity and gender .
9528964	0	insulin-like_growth_factor_1	120,148	MEK	41,44	insulin-like growth factor 1	MEK	3479	5609	Gene	Gene	required|nmod|START_ENTITY required|dep|END_ENTITY	Mitogen-activated protein kinase kinase -LRB- MEK -RRB- activity is required for inhibition of skeletal muscle differentiation by insulin-like_growth_factor_1 or fibroblast_growth_factor_2 .
22357625	0	insulin-like_growth_factor_1	16,44	Mex3c	0,5	insulin-like growth factor 1	Mex3c	16000(Tax:10090)	240396(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Mex3c regulates insulin-like_growth_factor_1 -LRB- IGF1 -RRB- expression and promotes postnatal growth .
11262401	0	insulin-like_growth_factor_1	58,86	extracellular_signal-regulated_kinase	126,163	insulin-like growth factor 1	extracellular signal-regulated kinase	16000(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Effects of stimulation of AMP-activated protein kinase on insulin-like_growth_factor_1 - and epidermal_growth_factor-dependent extracellular_signal-regulated_kinase pathway .
10848878	0	insulin-like_growth_factor_1	11,39	growth_hormone	78,92	insulin-like growth factor 1	growth hormone	3479	2688	Gene	Gene	reference|amod|START_ENTITY use|nmod|reference values|nsubj|use values|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	The use of insulin-like_growth_factor_1 reference values for the diagnosis of growth_hormone deficiency in prepubertal children .
15178913	0	insulin-like_growth_factor_1	95,123	growth_hormone	24,38	insulin-like growth factor 1	growth hormone	3479	2688	Gene	Gene	deficiency|amod|START_ENTITY effect|nmod|deficiency explore|dobj|effect model|acl|explore Laron_syndrome|dep|model Laron_syndrome|appos|insensitivity insensitivity|amod|END_ENTITY	Laron_syndrome -LRB- primary growth_hormone insensitivity -RRB- : a unique model to explore the effect of insulin-like_growth_factor_1 deficiency on human hair .
16984235	0	insulin-like_growth_factor_1	75,103	growth_hormone	35,49	insulin-like growth factor 1	growth hormone	3479	2688	Gene	Gene	administration|amod|START_ENTITY concentrations|nmod|administration concentrations|compound|END_ENTITY	Short-term suppression of elevated growth_hormone concentrations following insulin-like_growth_factor_1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates .
23648743	0	insulin-like_growth_factor_1	60,88	growth_hormone	221,235	insulin-like growth factor 1	growth hormone	3479	2688	Gene	Gene	activity|nmod|START_ENTITY Monitoring|nmod|activity Monitoring|parataxis|gene gene|amod|END_ENTITY	Monitoring for potential residual_disease activity by serum insulin-like_growth_factor_1 and soluble Klotho in patients with acromegaly after pituitary surgery : is there an impact of the genomic deletion of exon 3 in the growth_hormone receptor -LRB- d3-GHR -RRB- gene on `` safe '' GH cut-off values ?
8389243	0	insulin-like_growth_factor_1	20,48	growth_hormone	4,18	insulin-like growth factor 1	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	axis|amod|START_ENTITY mediator|nsubj|axis END_ENTITY|dep|mediator	The growth_hormone : insulin-like_growth_factor_1 axis is a mediator of diet restriction-induced inhibition_of_mononuclear_cell_leukemia in Fischer rats .
9500574	0	insulin-like_growth_factor_1	145,173	growth_hormone	6,20	insulin-like growth factor 1	growth hormone	3479	2688	Gene	Gene	cholesterol|nmod|START_ENTITY correlated|nmod|cholesterol correlated|nsubjpass|levels levels|compound|END_ENTITY	Basal growth_hormone levels in women are positively correlated with high-density lipoprotein cholesterol and apolipoprotein_A-I independently of insulin-like_growth_factor_1 or insulin .
9923061	0	insulin-like_growth_factor_1	109,137	growth_hormone	56,70	insulin-like growth factor 1	growth hormone	3479	2688	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Improved nasal breathing in snorers increases nocturnal growth_hormone secretion and serum concentrations of insulin-like_growth_factor_1 subsequently .
18939362	0	insulin-like_growth_factor_1	14,42	tumor_necrosis_factor_alpha	98,125	insulin-like growth factor 1	tumor necrosis factor alpha	3479	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Influence of insulin-like_growth_factor_1 on PECAM-1 and ICAM-1 adhesion molecules expression in tumor_necrosis_factor_alpha and hyperglycemia induced umbilical vein endothelial cells -RSB- .
10524682	0	insulin-like_growth_factor_1	58,86	urokinase_plasminogen_activator	23,54	insulin-like growth factor 1	urokinase plasminogen activator	3479	5328	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Abnormal regulation of urokinase_plasminogen_activator by insulin-like_growth_factor_1 in human osteoarthritic_subchondral_osteoblasts .
8910616	0	insulin-like_growth_factor_1	51,79	vascular_endothelial_growth_factor	13,47	insulin-like growth factor 1	vascular endothelial growth factor	3479	7422	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by insulin-like_growth_factor_1 in colorectal_carcinoma .
12800242	0	insulin-like_growth_factor_1_and_insulin-like_growth_factor_1_receptor	14,84	interleukin-10	109,123	insulin-like growth factor 1 and insulin-like growth factor 1 receptor	interleukin-10	24482;25718	25325(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_1_and_insulin-like_growth_factor_1_receptor and its intervention by interleukin-10 in experimental hepatic_fibrosis .
23710710	0	insulin-like_growth_factor_1_receptor	45,82	Akt	83,86	insulin-like growth factor 1 receptor	Akt	3480	207	Gene	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	Heterogeneity_of_neuroblastoma cell lines in insulin-like_growth_factor_1_receptor / Akt pathway-mediated cell proliferative responses .
24765210	0	insulin-like_growth_factor_1_receptor	16,53	BRCA1	0,5	insulin-like growth factor 1 receptor	BRCA1	3480	672	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	BRCA1 regulates insulin-like_growth_factor_1_receptor levels in ovarian_cancer .
11423532	0	insulin-like_growth_factor_1_receptor	15,52	EHD1	58,62	insulin-like growth factor 1 receptor	EHD1	100768531	100761397	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of insulin-like_growth_factor_1_receptor with EHD1 and SNAP29 .
21494688	0	insulin-like_growth_factor_1_receptor	67,104	IGF1R	106,111	insulin-like growth factor 1 receptor	IGF1R	3480	3480	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Targeted morphoproteomic profiling of Ewing 's _ sarcoma treated with insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- inhibitors : response/resistance signatures .
23780396	0	insulin-like_growth_factor_1_receptor	52,89	IGF1R	91,96	insulin-like growth factor 1 receptor	IGF1R	281848(Tax:9913)	281848(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of two SNPs in the coding region of the insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- gene with growth-related traits in Angus cattle .
24033502	0	insulin-like_growth_factor_1_receptor	81,118	IGF1R	120,125	insulin-like growth factor 1 receptor	IGF1R	3480	3480	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Familial_short_stature is associated with a novel dominant-negative heterozygous insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- mutation .
24392142	0	insulin-like_growth_factor_1_receptor	51,88	IGF1R	90,95	insulin-like growth factor 1 receptor	IGF1R	3480	3480	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of polymorphisms and haplotypes in the insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- gene with the risk of breast_cancer in Korean women .
23974362	0	insulin-like_growth_factor_1_receptor	45,82	let-7a1	10,17	insulin-like growth factor 1 receptor	let-7a1	3480	406881	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	The miRNA let-7a1 inhibits the expression of insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- in prostate_cancer PC-3 cells .
26623053	0	insulin-like_growth_factor_1_receptor	27,64	tyrosine_kinase	65,80	insulin-like growth factor 1 receptor	tyrosine kinase	3480	7294	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Mutational analysis of the insulin-like_growth_factor_1_receptor tyrosine_kinase domain in non-small_cell_lung_cancer patients .
2544239	0	insulin-like_growth_factor_1_receptors	20,58	IGF1-R	60,66	insulin-like growth factor 1 receptors	IGF1-R	3480	3480	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of insulin-like_growth_factor_1_receptors -LRB- IGF1-R -RRB- in human breast_cancer cell lines .
16330588	0	insulin-like_growth_factor_2	24,52	IGF2	59,63	insulin-like growth factor 2	IGF2	3481	3481	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the insulin-like_growth_factor_2 gene -LRB- IGF2 -RRB- and scores on the Eating Attitudes Test in nonclinical subjects : a family-based study .
19785908	0	insulin-like_growth_factor_2	54,82	IGF2	85,89	insulin-like growth factor 2	IGF2	281240(Tax:9913)	281240(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of polymorphisms in exons 2 and 10 of the insulin-like_growth_factor_2 -LRB- IGF2 -RRB- gene with milk production traits in Polish Holstein-Friesian cattle .
24173291	0	insulin-like_growth_factor_2	4,32	IGF2	34,38	insulin-like growth factor 2	IGF2	3481	3481	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The insulin-like_growth_factor_2 -LRB- IGF2 -RRB- mRNA-binding protein p62/IGF2BP2 -2 as a promoter of NAFLD and HCC ?
27083047	0	insulin-like_growth_factor_2	67,95	IGF2	97,101	insulin-like growth factor 2	IGF2	3481	3481	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Retrograde fibroblast_growth_factor_22 -LRB- FGF22 -RRB- signaling regulates insulin-like_growth_factor_2 -LRB- IGF2 -RRB- expression for activity-dependent synapse stabilization in the mammalian brain .
22514330	0	insulin-like_growth_factor_2	39,67	Igf2	69,73	insulin-like growth factor 2	Igf2	16002(Tax:10090)	16002(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	IkB kinase/nuclear factor kB-dependent insulin-like_growth_factor_2 -LRB- Igf2 -RRB- expression regulates synapse formation and spine maturation via Igf2 receptor signaling .
7553624	0	insulin-like_growth_factor_2	26,54	WT1	0,3	insulin-like growth factor 2	WT1	3481	7490	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	WT1 induces expression of insulin-like_growth_factor_2 in Wilms ' _ tumor cells .
27083047	0	insulin-like_growth_factor_2	67,95	fibroblast_growth_factor_22	11,38	insulin-like growth factor 2	fibroblast growth factor 22	3481	27006	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Retrograde fibroblast_growth_factor_22 -LRB- FGF22 -RRB- signaling regulates insulin-like_growth_factor_2 -LRB- IGF2 -RRB- expression for activity-dependent synapse stabilization in the mammalian brain .
25472129	0	insulin-like_growth_factor_2	22,50	igf2	52,56	insulin-like growth factor 2	igf2	281240(Tax:9913)	281240(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	80 DNA methylation of insulin-like_growth_factor_2 -LRB- igf2 -RRB- gene in day 14 in vitro-produced bovine embryos of different sizes .
22221028	0	insulin-like_growth_factor_2_receptor	56,93	IGF2R	100,105	insulin-like growth factor 2 receptor	IGF2R	281849(Tax:9913)	281849(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in the imprinted bovine insulin-like_growth_factor_2_receptor gene -LRB- IGF2R -RRB- are associated with body size traits in Irish Holstein-Friesian cattle .
7720562	0	insulin-like_growth_factor_2_receptor	118,155	Igf2r	157,162	insulin-like growth factor 2 receptor	Igf2r	16004(Tax:10090)	16004(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mouse embryonic germ -LRB- EG -RRB- cell lines : transmission through the germline and differences in the methylation imprint of insulin-like_growth_factor_2_receptor -LRB- Igf2r -RRB- gene compared with embryonic stem -LRB- ES -RRB- cell lines .
16862465	0	insulin-like_growth_factor_I	29,57	GH	186,188	insulin-like growth factor I	GH	3479	2688	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Pregnancy-induced changes in insulin-like_growth_factor_I -LRB- IGF-I -RRB- , insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- , and acid-labile_subunit -LRB- ALS -RRB- in patients with growth_hormone _ -LRB- GH -RRB- _ deficiency and excess .
1480177	0	insulin-like_growth_factor_I	33,61	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Growth_hormone rapidly activates insulin-like_growth_factor_I gene transcription in vivo .
2738797	0	insulin-like_growth_factor_I	53,81	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	3479	2688	Gene	Gene	levels|compound|START_ENTITY rise|nmod|levels impedes|dobj|rise impedes|nsubj|deficiency deficiency|amod|END_ENTITY	Growth_hormone deficiency impedes the rise in plasma insulin-like_growth_factor_I levels associated with precocious_puberty .
2918420	0	insulin-like_growth_factor_I	26,54	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	3479	2688	Gene	Gene	actions|compound|START_ENTITY stimulates|dobj|actions stimulates|nsubj|END_ENTITY	Growth_hormone stimulates insulin-like_growth_factor_I actions on adult articular chondrocytes .
3654912	0	insulin-like_growth_factor_I	82,110	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	3479	2688	Gene	Gene	relationship|nmod|START_ENTITY treatment|dep|relationship treatment|amod|END_ENTITY	Growth_hormone treatment in short children : relationship between growth and serum insulin-like_growth_factor_I and II levels .
3755433	0	insulin-like_growth_factor_I	42,70	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	3479	81668(Tax:10116)	Gene	Gene	RNA|compound|START_ENTITY abundance|nmod|RNA regulates|dobj|abundance regulates|nsubj|END_ENTITY	Growth_hormone regulates the abundance of insulin-like_growth_factor_I RNA in adult rat liver .
7556882	0	insulin-like_growth_factor_I	25,53	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	3479	2688	Gene	Gene	START_ENTITY|nsubj|amplifies amplifies|amod|END_ENTITY	Growth_hormone amplifies insulin-like_growth_factor_I induced progesterone accumulation and P450scc mRNA expression .
7711889	0	insulin-like_growth_factor_I	30,58	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Growth_hormone -LRB- GH -RRB- modulates insulin-like_growth_factor_I -LRB- IGF-I -RRB- and type I IGF receptor mRNA levels in the ovary of prepubertal GH-deficient rats .
9437510	0	insulin-like_growth_factor_I	85,113	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	100008668(Tax:9986)	100356068(Tax:9986)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|amod|END_ENTITY	Growth_hormone stimulatory effects on osteoclastic resorption are partly mediated by insulin-like_growth_factor_I : an in vitro study .
9589657	0	insulin-like_growth_factor_I	50,78	Growth_hormone	0,14	insulin-like growth factor I	Growth hormone	3479	2688	Gene	Gene	expression|amod|START_ENTITY decrease|nmod|expression prevents|dobj|decrease prevents|nsubj|treatment treatment|amod|END_ENTITY	Growth_hormone treatment prevents the decrease in insulin-like_growth_factor_I gene expression in patients undergoing abdominal surgery .
10199777	0	insulin-like_growth_factor_I	35,63	IGF-I	65,70	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Low serum levels of free and total insulin-like_growth_factor_I -LRB- IGF-I -RRB- in patients with anorexia_nervosa are not associated with increased IGF-binding_protein-3 proteolysis .
10323388	0	insulin-like_growth_factor_I	29,57	IGF-I	59,64	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of recombinant human insulin-like_growth_factor_I -LRB- IGF-I -RRB- therapy on the growth hormone-IGF system of a patient with a partial IGF-I gene deletion .
11095464	0	insulin-like_growth_factor_I	16,44	IGF-I	46,51	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , IGF-binding_protein-3 , and prostate-specific_antigen as predictors of clinical prostate_cancer .
14557458	0	insulin-like_growth_factor_I	20,48	IGF-I	50,55	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between insulin-like_growth_factor_I -LRB- IGF-I -RRB- polymorphisms , circulating IGF-I , and pre - and postnatal growth in two European small for gestational age populations .
1478191	0	insulin-like_growth_factor_I	50,78	IGF-I	80,85	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Effects of age , sex and renal function on urinary insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels in adults .
15098919	0	insulin-like_growth_factor_I	14,42	IGF-I	44,49	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene and of genes for IGF-binding_proteins_1 , _ 2 , _ 3 , _ 4 -LRB- IGFBP-1-IGFBP-4 -RRB- in non-neoplastic human thyroid cells and in certain human thyroid_cancers .
1510832	0	insulin-like_growth_factor_I	11,39	IGF-I	41,46	insulin-like growth factor I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on Sertoli cell metabolism in the pubescent rat -RSB- .
15563671	0	insulin-like_growth_factor_I	18,46	IGF-I	48,53	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- in neonatal outcome .
15627646	0	insulin-like_growth_factor_I	19,47	IGF-I	49,54	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|appos|END_ENTITY	An accumulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in human myometrium and uterine leiomyomas in various stages of tumour growth .
1661128	0	insulin-like_growth_factor_I	11,39	IGF-I	41,46	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on enzymatic activity in human adrenocortical cells .
1667296	0	insulin-like_growth_factor_I	39,67	IGF-I	69,74	insulin-like growth factor I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Climbing fiber deafferentation reduces insulin-like_growth_factor_I -LRB- IGF-I -RRB- content in cerebellum .
2028707	0	insulin-like_growth_factor_I	35,63	IGF-I	65,70	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Effects of aging and sex on plasma insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels in normal adults .
20979700	0	insulin-like_growth_factor_I	19,47	IGF-I	49,54	insulin-like growth factor I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in the mouse diaphragm during sepsis .
2156680	0	insulin-like_growth_factor_I	50,78	IGF-I	80,85	insulin-like growth factor I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	1,25-Dihydroxyvitamin _ D3 -LSB- 1,25 - -LRB- OH -RRB- 2D3 -RSB- increases insulin-like_growth_factor_I -LRB- IGF-I -RRB- receptors in clonal osteoblastic cells .
21882221	0	insulin-like_growth_factor_I	45,73	IGF-I	75,80	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Forkhead_box_A1 -LRB- FOXA1 -RRB- is a key mediator of insulin-like_growth_factor_I -LRB- IGF-I -RRB- activity .
21893211	0	insulin-like_growth_factor_I	42,70	IGF-I	72,77	insulin-like growth factor I	IGF-I	103384875	103384875	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , expression analysis of insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene and IGF-I serum concentration in female and male Tongue_sole -LRB- Cynoglossus_semilaevis -RRB- .
2387267	0	insulin-like_growth_factor_I	4,32	IGF-I	34,39	insulin-like growth factor I	IGF-I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene is expressed in chick embryos during early organogenesis .
23886838	0	insulin-like_growth_factor_I	27,55	IGF-I	57,62	insulin-like growth factor I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Osteo-promoting effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in a mouse_model_of_type_1_diabetes .
2969239	0	insulin-like_growth_factor_I	20,48	IGF-I	50,55	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Characterization of insulin-like_growth_factor_I -LRB- IGF-I -RRB- receptors of human breast_cancer cells .
3108068	0	insulin-like_growth_factor_I	11,39	IGF-I	41,46	insulin-like growth factor I	IGF-I	100327329(Tax:9031)	100327329(Tax:9031)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
7515839	0	insulin-like_growth_factor_I	37,65	IGF-I	67,72	insulin-like growth factor I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization and expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in the mammary gland during rat gestation and lactation .
7577069	0	insulin-like_growth_factor_I	14,42	IGF-I	44,49	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in female_breast_cancer as related to established prognostic factors and long-term prognosis .
7951495	0	insulin-like_growth_factor_I	28,56	IGF-I	58,63	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Relationship between plasma insulin-like_growth_factor_I -LRB- IGF-I -RRB- levels and body mass index -LRB- BMI -RRB- in adults .
7978067	0	insulin-like_growth_factor_I	14,42	IGF-I	44,49	insulin-like growth factor I	IGF-I	3479	3479	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- in nevi and melanomas .
8793618	0	insulin-like_growth_factor_I	26,54	IGF-I	56,61	insulin-like growth factor I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Delayed expression of the insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene in the XY sex-reversed female mouse ovary .
8830986	0	insulin-like_growth_factor_I	14,42	IGF-I	44,49	insulin-like growth factor I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Expression of insulin-like_growth_factor_I -LRB- IGF-I -RRB- mRNA variants in rat bone .
9389533	0	insulin-like_growth_factor_I	14,42	IGF-I	44,49	insulin-like growth factor I	IGF-I	16000(Tax:10090)	16000(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- gene expression in brain of transgenic_mice expressing an IGF-I-luciferase fusion gene .
9794461	0	insulin-like_growth_factor_I	21,49	IGF-I	51,56	insulin-like growth factor I	IGF-I	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	Reduction|nmod|START_ENTITY Reduction|appos|END_ENTITY	Reduction of hepatic insulin-like_growth_factor_I -LRB- IGF-I -RRB- messenger ribonucleic acid -LRB- mRNA -RRB- during fasting is associated with diminished splicing of IGF-I pre-mRNA and decreased stability of cytoplasmic IGF-I mRNA .
10404828	0	insulin-like_growth_factor_I	24,52	IGF-II	64,70	insulin-like growth factor I	IGF-II	3479	3481	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|synthesis synthesis|amod|END_ENTITY	Paracrine regulation of insulin-like_growth_factor_I -LRB- IGF-I -RRB- an IGF-II on prostaglandins_F2alpha and E2 synthesis by human corpus luteum in vitro : a possible balance of luteotropic and luteolytic effects .
11095464	0	insulin-like_growth_factor_I	16,44	IGF-II	54,60	insulin-like growth factor I	IGF-II	3479	3481	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , IGF-binding_protein-3 , and prostate-specific_antigen as predictors of clinical prostate_cancer .
7588270	0	insulin-like_growth_factor_I	48,76	IGF-II	86,92	insulin-like growth factor I	IGF-II	3479	3481	Gene	Gene	acids|nmod|START_ENTITY acids|amod|END_ENTITY	Localization of messenger ribonucleic acids for insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-II , and the type 1 IGF receptor in the ovine ovary throughout the estrous cycle .
15126555	0	insulin-like_growth_factor_I	67,95	IGFBP-3	128,135	insulin-like growth factor I	IGFBP-3	3479	3486	Gene	Gene	START_ENTITY|appos|IGF-binding_protein-3 IGF-binding_protein-3|appos|END_ENTITY	Sustained elevation of pulsatile growth_hormone -LRB- GH -RRB- secretion and insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-3 -LRB- IGFBP-3 -RRB- , and IGFBP-5 concentrations during 30-day continuous subcutaneous infusion of GH-releasing peptide-2 in older men and women .
24562308	0	insulin-like_growth_factor_I	39,67	Lactoferrin	0,11	insulin-like growth factor I	Lactoferrin	24482(Tax:10116)	301034(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Lactoferrin inhibits apoptosis through insulin-like_growth_factor_I in primary rat osteoblasts .
7902706	0	insulin-like_growth_factor_I	37,65	PrP	73,76	insulin-like growth factor I	PrP	3479	5621	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Recombinant human growth hormone and insulin-like_growth_factor_I induce PrP gene expression in PC12 cells .
2164356	0	insulin-like_growth_factor_I	10,38	alcohol_dehydrogenase	46,67	insulin-like growth factor I	alcohol dehydrogenase	24482(Tax:10116)	78959(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of insulin-like_growth_factor_I on rat alcohol_dehydrogenase in primary hepatocyte culture .
2185466	0	insulin-like_growth_factor_I	62,90	delta_1-crystallin	35,53	insulin-like growth factor I	delta 1-crystallin	100327329(Tax:9031)	396498(Tax:9031)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional stimulation of the delta_1-crystallin gene by insulin-like_growth_factor_I and insulin requires DNA cis elements in chicken .
10642569	0	insulin-like_growth_factor_I	10,38	follicle-stimulating_hormone_receptor	43,80	insulin-like growth factor I	follicle-stimulating hormone receptor	24482(Tax:10116)	25449(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	A role of insulin-like_growth_factor_I for follicle-stimulating_hormone_receptor expression in rat granulosa cells .
10336548	0	insulin-like_growth_factor_I	101,129	growth_hormone	62,76	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	model|nmod|START_ENTITY model|nmod|effects effects|compound|END_ENTITY	A pharmacokinetic/pharmacodynamic model for recombinant human growth_hormone effects on induction of insulin-like_growth_factor_I in monkeys .
10720049	0	insulin-like_growth_factor_I	21,49	growth_hormone	62,76	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	response|compound|START_ENTITY response|nmod|treatment treatment|amod|END_ENTITY	Gender difference in insulin-like_growth_factor_I response to growth_hormone -LRB- GH -RRB- treatment in GH-deficient adults : role of sex hormone replacement .
10965059	0	insulin-like_growth_factor_I	50,78	growth_hormone	25,39	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	action|nmod|START_ENTITY action|amod|END_ENTITY	Presumptive mediators of growth_hormone action on insulin-like_growth_factor_I release by porcine ovarian granulosa cells .
11684882	0	insulin-like_growth_factor_I	32,60	growth_hormone	89,103	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	available|nmod|START_ENTITY assays|xcomp|available assays|advcl|diagnosing diagnosing|dobj|deficiency deficiency|amod|END_ENTITY	Commercial assays available for insulin-like_growth_factor_I and their use in diagnosing growth_hormone deficiency .
11735250	0	insulin-like_growth_factor_I	32,60	growth_hormone	14,28	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	metabolism|compound|START_ENTITY effect|nmod|metabolism effect|nmod|END_ENTITY	The effect of growth_hormone on insulin-like_growth_factor_I and bone metabolism in distraction osteogenesis .
1282673	0	insulin-like_growth_factor_I	63,91	growth_hormone	10,24	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Effect of growth_hormone on levels of differentially processed insulin-like_growth_factor_I mRNAs in total and polysomal mRNA populations .
1453131	0	insulin-like_growth_factor_I	101,129	growth_hormone	37,51	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels correlates|advcl|circulating correlates|nsubj|bone_mineral_density bone_mineral_density|nmod|deficiency deficiency|compound|END_ENTITY	The bone_mineral_density in acquired growth_hormone deficiency correlates with circulating levels of insulin-like_growth_factor_I .
14997011	0	insulin-like_growth_factor_I	20,48	growth_hormone	130,144	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY binding|nsubj|Modulation binding|nmod|exogenous exogenous|amod|END_ENTITY	Modulation of brain insulin-like_growth_factor_I -LRB- IGF-I -RRB- binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth_hormone and IGF-I in juvenile rats .
1518079	0	insulin-like_growth_factor_I	27,55	growth_hormone	59,73	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|hormone hormone|compound|END_ENTITY	Differential regulation of insulin-like_growth_factor_I by growth_hormone and thyroid hormone in the heart of juvenile hypophysectomized rats .
16862465	0	insulin-like_growth_factor_I	29,57	growth_hormone	170,184	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	changes|nmod|START_ENTITY changes|nmod|patients patients|nmod|_ _|amod|END_ENTITY	Pregnancy-induced changes in insulin-like_growth_factor_I -LRB- IGF-I -RRB- , insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- , and acid-labile_subunit -LRB- ALS -RRB- in patients with growth_hormone _ -LRB- GH -RRB- _ deficiency and excess .
1723834	0	insulin-like_growth_factor_I	21,49	growth_hormone	110,124	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	START_ENTITY|nmod|case case|nmod|insensitivity insensitivity|amod|END_ENTITY	Effects of exogenous insulin-like_growth_factor_I on insulin-like growth factor binding proteins in a case of growth_hormone insensitivity -LRB- Laron-type -RRB- .
1879059	0	insulin-like_growth_factor_I	121,149	growth_hormone	39,53	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	gene|amod|START_ENTITY linkage|nmod|gene characteristics|dep|linkage characteristics|nmod|therapy therapy|amod|END_ENTITY	Growth characteristics and response to growth_hormone therapy in patients with hypochondroplasia : genetic linkage of the insulin-like_growth_factor_I gene at chromosome 12q23 to the disease in a subgroup of these patients .
19055455	0	insulin-like_growth_factor_I	28,56	growth_hormone	129,143	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	assays|nsubj|START_ENTITY assays|nmod|IGF-I IGF-I|nmod|END_ENTITY	Five commercially available insulin-like_growth_factor_I -LRB- IGF-I -RRB- assays in comparison to the former Nichols Advantage IGF-I in a growth_hormone treated population .
1991807	0	insulin-like_growth_factor_I	125,153	growth_hormone	94,108	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	secretion|appos|START_ENTITY END_ENTITY|dep|secretion	Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth_hormone -LRB- GH -RRB- secretion , insulin-like_growth_factor_I , and GH-binding protein in postmenopausal women .
2340951	0	insulin-like_growth_factor_I	15,43	growth_hormone	109,123	insulin-like growth factor I	growth hormone	100327329(Tax:9031)	378781(Tax:9031)	Gene	Gene	production|compound|START_ENTITY Stimulation|nmod|production hepatocytes|nsubj|Stimulation hepatocytes|nmod|END_ENTITY	Stimulation of insulin-like_growth_factor_I production in primary cultures of chicken hepatocytes by chicken growth_hormone .
23578901	0	insulin-like_growth_factor_I	74,102	growth_hormone	53,67	insulin-like growth factor I	growth hormone	100860838	102171600	Gene	Gene	_|nsubj|START_ENTITY _|advcl|Variation Variation|nmod|sequences sequences|nmod|END_ENTITY	Variation in sequences and mRNA expression levels of growth_hormone -LRB- GH -RRB- , insulin-like_growth_factor_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- genes between prolific Lezhi black goat and non-prolific Tibetan goat -LRB- Capra_hircus -RRB- .
2492219	0	insulin-like_growth_factor_I	45,73	growth_hormone	94,108	insulin-like growth factor I	growth hormone	3479	81668(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY interrelationship|nmod|effects interrelationship|nmod|secretion secretion|amod|END_ENTITY	The interrelationship between the effects of insulin-like_growth_factor_I and somatostatin on growth_hormone secretion by normal rat pituitary cells : the role of glucocorticoids .
2849979	0	insulin-like_growth_factor_I	78,106	growth_hormone	48,62	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Enhancement Enhancement|nmod|erythropoiesis erythropoiesis|acl|vitro vitro|nmod|END_ENTITY	Enhancement of erythropoiesis in vitro by human growth_hormone is mediated by insulin-like_growth_factor_I .
2982573	0	insulin-like_growth_factor_I	15,43	growth_hormone	75,89	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|dep|effect effect|nmod|END_ENTITY	Rat hepatocyte insulin-like_growth_factor_I and binding protein : effect of growth_hormone in vitro and in vivo .
3197637	0	insulin-like_growth_factor_I	87,115	growth_hormone	22,36	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	acid|amod|START_ENTITY increases|dobj|acid increases|nsubj|END_ENTITY	Pulsatile intravenous growth_hormone -LRB- GH -RRB- infusion to hypophysectomized rats increases insulin-like_growth_factor_I messenger ribonucleic acid in skeletal tissues more effectively than continuous GH infusion .
3383777	0	insulin-like_growth_factor_I	14,42	growth_hormone	86,100	insulin-like growth factor I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	START_ENTITY|nmod|transgenic_mice transgenic_mice|nmod|levels levels|nmod|END_ENTITY	Expression of insulin-like_growth_factor_I in transgenic_mice with elevated levels of growth_hormone is correlated with growth .
3453891	0	insulin-like_growth_factor_I	25,53	growth_hormone	161,175	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|messenger messenger|nmod|END_ENTITY	Molecular cloning of rat insulin-like_growth_factor_I complementary deoxyribonucleic acids : differential messenger ribonucleic acid processing and regulation by growth_hormone in extrahepatic tissues .
3467309	0	insulin-like_growth_factor_I	14,42	growth_hormone	62,76	insulin-like growth factor I	growth hormone	16000(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of insulin-like_growth_factor_I gene expression by growth_hormone .
3654610	0	insulin-like_growth_factor_I	54,82	growth_hormone	20,34	insulin-like growth factor I	growth hormone	24482(Tax:10116)	2688	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of human growth_hormone gene expression by insulin-like_growth_factor_I in transfected cells .
8514857	0	insulin-like_growth_factor_I	52,80	growth_hormone	127,141	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	infusion|nmod|START_ENTITY suppresses|nsubj|infusion suppresses|dobj|secretion secretion|compound|END_ENTITY	A low dose euglycemic infusion of recombinant human insulin-like_growth_factor_I rapidly suppresses fasting-enhanced pulsatile growth_hormone secretion in humans .
8567947	1	insulin-like_growth_factor_I	118,146	growth_hormone	84,98	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|stimulation stimulation|nmod|END_ENTITY	In vivo stimulation by growth_hormone is not mediated by insulin-like_growth_factor_I .
8630517	0	insulin-like_growth_factor_I	12,40	growth_hormone	59,73	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	concentrations|compound|START_ENTITY free|dobj|concentrations free|nmod|deficiency deficiency|amod|END_ENTITY	Plasma free insulin-like_growth_factor_I concentrations in growth_hormone deficiency in children and adolescents .
8768860	0	insulin-like_growth_factor_I	51,79	growth_hormone	93,107	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	A randomized , placebo-controlled trial of combined insulin-like_growth_factor_I and low dose growth_hormone therapy for wasting associated with human_immunodeficiency_virus_infection .
8770900	0	insulin-like_growth_factor_I	53,81	growth_hormone	31,45	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|infusions infusions|nmod|END_ENTITY	Effects of 14-day infusions of growth_hormone and/or insulin-like_growth_factor_I on the obesity of growing Zucker rats .
8810735	0	insulin-like_growth_factor_I	33,61	growth_hormone	99,113	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	levels|amod|START_ENTITY increase|nmod|levels depends|nsubj|increase depends|nmod|levels levels|nmod|END_ENTITY	Testosterone-induced increase of insulin-like_growth_factor_I levels depends upon normal levels of growth_hormone .
8989263	0	insulin-like_growth_factor_I	6,34	growth_hormone	146,160	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	IGF-binding_protein-1_and|nsubj|START_ENTITY IGF-binding_protein-1_and|nmod|therapy therapy|amod|END_ENTITY	Serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- , IGF-binding_protein-1_and _ -3 , and the acid-labile_subunit as serum markers of body composition during growth_hormone -LRB- GH -RRB- therapy in adults with GH_deficiency .
9025720	0	insulin-like_growth_factor_I	115,143	growth_hormone	85,99	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY stimulation|nmod|synthesis stimulation|amod|END_ENTITY	Proinflammatory cytokines interleukin_1_beta and tumor_necrosis_factor_alpha inhibit growth_hormone stimulation of insulin-like_growth_factor_I synthesis and growth_hormone_receptor mRNA levels in cultured rat liver cells .
9104840	0	insulin-like_growth_factor_I	10,38	growth_hormone	46,60	insulin-like growth factor I	growth hormone	24482(Tax:10116)	81668(Tax:10116)	Gene	Gene	and/or|compound|START_ENTITY Effect|nmod|and/or END_ENTITY|nsubj|Effect	Effect of insulin-like_growth_factor_I and/or growth_hormone on diaphragm of malnourished adolescent rats .
9253329	0	insulin-like_growth_factor_I	11,39	growth_hormone	54,68	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	Effects|nmod|START_ENTITY combined|nsubj|Effects combined|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I combined with growth_hormone on glucocorticoid-induced whole-body protein catabolism in man .
9284715	0	insulin-like_growth_factor_I	66,94	growth_hormone	19,33	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	serum|dobj|START_ENTITY relates|xcomp|serum relates|nsubj|response response|nmod|treatment treatment|compound|END_ENTITY	Growth response to growth_hormone -LRB- GH -RRB- treatment relates to serum insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 in short children with various GH secretion capacities .
9661598	0	insulin-like_growth_factor_I	39,67	growth_hormone	151,165	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	assay|nmod|START_ENTITY assay|nmod|evaluation evaluation|nmod|status status|amod|END_ENTITY	Filter paper blood spot assay of human insulin-like_growth_factor_I -LRB- IGF-I -RRB- and IGF-binding_protein-3 and preliminary application in the evaluation of growth_hormone status .
9920097	0	insulin-like_growth_factor_I	29,57	growth_hormone	76,90	insulin-like growth factor I	growth hormone	3479	2688	Gene	Gene	administration|compound|START_ENTITY Effects|nmod|administration Effects|nmod|END_ENTITY	Effects of recombinant human insulin-like_growth_factor_I administration on growth_hormone -LRB- GH -RRB- secretion , both spontaneous and stimulated by GH-releasing hormone or hexarelin , a peptidyl GH secretagogue , in humans .
8943227	0	insulin-like_growth_factor_I	78,106	hepatocyte_nuclear_factor_3beta	4,35	insulin-like growth factor I	hepatocyte nuclear factor 3beta	3479	3170	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene stimulates|dobj|transcription stimulates|nsubj|END_ENTITY	The hepatocyte_nuclear_factor_3beta stimulates the transcription of the human insulin-like_growth_factor_I gene in a direct and indirect manner .
16306401	0	insulin-like_growth_factor_I	63,91	megalin	15,22	insulin-like growth factor I	megalin	3479	4036	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Choroid plexus megalin is involved in neuroprotection by serum insulin-like_growth_factor_I .
632300	0	insulin-like_growth_factor_I	33,61	proinsulin	95,105	insulin-like growth factor I	proinsulin	3479	3630	Gene	Gene	sequence|nmod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human insulin-like_growth_factor_I and its structural homology with proinsulin .
7674231	0	insulin-like_growth_factor_I	38,66	somatomedin_C	24,37	insulin-like growth factor I	somatomedin C	3479	3479	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Cyclosporin_A increases somatomedin_C insulin-like_growth_factor_I levels in chronic rheumatic_diseases .
7473417	0	insulin-like_growth_factor_I	11,39	transforming_growth_factor_alpha	62,94	insulin-like growth factor I	transforming growth factor alpha	100327329(Tax:9031)	414743(Tax:9031)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I and interactions with transforming_growth_factor_alpha and LH on proliferation of chicken granulosa cells and production of progesterone in culture .
15781617	0	insulin-like_growth_factor_I	23,51	vascular_endothelial_growth_factor	65,99	insulin-like growth factor I	vascular endothelial growth factor	3479	7422	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Activated Ras enhances insulin-like_growth_factor_I induction of vascular_endothelial_growth_factor in prostate epithelial cells .
8641174	0	insulin-like_growth_factor_I	130,158	vascular_endothelial_growth_factor	23,57	insulin-like growth factor I	vascular endothelial growth factor	16000(Tax:10090)	7422	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	Enhanced expression of vascular_endothelial_growth_factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like_growth_factor_I .
9313759	0	insulin-like_growth_factor_I	63,91	vascular_endothelial_growth_factor	14,48	insulin-like growth factor I	vascular endothelial growth factor	3479	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by insulin-like_growth_factor_I .
7988440	0	insulin-like_growth_factor_I	86,114	vasoactive_intestinal_peptide	13,42	insulin-like growth factor I	vasoactive intestinal peptide	24482(Tax:10116)	117064(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of vasoactive_intestinal_peptide gene expression and prolactin secretion by insulin-like_growth_factor_I in rat pituitary cells : evidence for an autoparacrine regulatory system .
23035551	0	insulin-like_growth_factor_II	20,49	IGF2	51,55	insulin-like growth factor II	IGF2	3481	3481	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Association of the insulin-like_growth_factor_II -LRB- IGF2 -RRB- gene with human cognitive functions -RSB- .
9376897	0	insulin-like_growth_factor_II	21,50	IGF2	52,56	insulin-like growth factor II	IGF2	3481	3481	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Apal polymorphism in insulin-like_growth_factor_II -LRB- IGF2 -RRB- gene and weight in middle-aged males .
10949925	0	insulin-like_growth_factor_II	18,47	p53	86,89	insulin-like growth factor II	p53	3481	7157	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|249 249|compound|END_ENTITY	Activation of the insulin-like_growth_factor_II transcription by aflatoxin_B1 induced p53 mutant 249 is caused by activation of transcription complexes ; implications for a gain-of-function during the formation of hepatocellular_carcinoma .
9502429	0	insulin-like_growth_factor_II	20,49	p53	0,3	insulin-like growth factor II	p53	3481	7157	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p53 regulates human insulin-like_growth_factor_II gene expression through active P4 promoter in rhabdomyosarcoma cells .
9111084	0	insulin-like_growth_factor_I_receptor	36,73	14-3-3	0,6	insulin-like growth factor I receptor	14-3-3	3480	10971	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	14-3-3 -LRB- epsilon -RRB- interacts with the insulin-like_growth_factor_I_receptor and insulin_receptor substrate I in a phosphoserine-dependent manner .
16478996	0	insulin-like_growth_factor_I_receptor	4,41	Akt	58,61	insulin-like growth factor I receptor	Akt	16001(Tax:10090)	11651(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	The insulin-like_growth_factor_I_receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase .
16322063	0	insulin-like_growth_factor_I_receptor	43,80	Angiotensin_II	0,14	insulin-like growth factor I receptor	Angiotensin II	25718(Tax:10116)	24179(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Angiotensin_II stimulates transcription of insulin-like_growth_factor_I_receptor in vascular smooth muscle cells : role of nuclear factor-kappaB .
8175666	0	insulin-like_growth_factor_I_receptor	34,71	IGF-I-R	73,80	insulin-like growth factor I receptor	IGF-I-R	100768531	100768531	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional repression of the insulin-like_growth_factor_I_receptor -LRB- IGF-I-R -RRB- gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site .
26595309	0	insulin-like_growth_factor_I_receptor	24,61	IGF-IR	63,69	insulin-like growth factor I receptor	IGF-IR	16001(Tax:10090)	16001(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The role of selenium in insulin-like_growth_factor_I_receptor -LRB- IGF-IR -RRB- expression and regulation of apoptosis in mouse osteoblasts .
11278691	0	insulin-like_growth_factor_I_receptor	41,78	Id2	14,17	insulin-like growth factor I receptor	Id2	16001(Tax:10090)	15902(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of Id2 gene expression by the insulin-like_growth_factor_I_receptor requires signaling by phosphatidylinositol_3-kinase .
10747872	0	insulin-like_growth_factor_I_receptor	33,70	STAT3	13,18	insulin-like growth factor I receptor	STAT3	3480	6774	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of STAT3 activation by insulin-like_growth_factor_I_receptor .
16035620	0	insulin-like_growth_factor_I_receptor	27,64	Sp1	129,132	insulin-like growth factor I receptor	Sp1	3480	6667	Gene	Gene	level|nmod|START_ENTITY associated|nsubjpass|level associated|nmod|expression expression|nmod|END_ENTITY	A high expression level of insulin-like_growth_factor_I_receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric_cancer .
7491107	0	insulin-like_growth_factor_I_receptor	14,51	Sp1	71,74	insulin-like growth factor I receptor	Sp1	25718(Tax:10116)	24790(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of insulin-like_growth_factor_I_receptor gene expression by Sp1 : physical and functional interactions of Sp1 at GC boxes and at a CT element .
8175666	0	insulin-like_growth_factor_I_receptor	34,71	WT1	111,114	insulin-like growth factor I receptor	WT1	100768531	100767732	Gene	Gene	gene|amod|START_ENTITY repression|nmod|gene repression|nmod|END_ENTITY	Transcriptional repression of the insulin-like_growth_factor_I_receptor -LRB- IGF-I-R -RRB- gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site .
8873895	0	insulin-like_growth_factor_I_receptor	14,51	WT1	99,102	insulin-like growth factor I receptor	WT1	3480	7490	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of insulin-like_growth_factor_I_receptor gene expression by the Wilms ' _ tumor suppressor WT1 .
10226804	0	insulin-like_growth_factor_binding_protein-1	86,130	IGFBP-1	132,139	insulin-like growth factor binding protein-1	IGFBP-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Interleukin-1_alpha -LRB- IL-1_alpha -RRB- and tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- regulate insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- levels and mRNA abundance in vivo and in vitro .
10425467	0	insulin-like_growth_factor_binding_protein-1	14,58	IGFBP-1	60,67	insulin-like growth factor binding protein-1	IGFBP-1	3484	3484	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA in the ovine uterus throughout the oestrous cycle and early pregnancy .
11044255	0	insulin-like_growth_factor_binding_protein-1	21,65	IGFBP-1	67,74	insulin-like growth factor binding protein-1	IGFBP-1	25685(Tax:10116)	25685(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of hepatic insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- in rats by dietary n-6_polyunsaturated_fatty_acids .
11147791	0	insulin-like_growth_factor_binding_protein-1	29,73	IGFBP-1	103,110	insulin-like growth factor binding protein-1	IGFBP-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Physiological differences in insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation in IGFBP-1 transgenic_mice .
11147791	0	insulin-like_growth_factor_binding_protein-1	29,73	IGFBP-1	75,82	insulin-like growth factor binding protein-1	IGFBP-1	16006(Tax:10090)	16006(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Physiological differences in insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation in IGFBP-1 transgenic_mice .
15200677	0	insulin-like_growth_factor_binding_protein-1	67,111	IGFBP-1	113,120	insulin-like growth factor binding protein-1	IGFBP-1	101026642	101026642	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Uterine receptivity and implantation : the regulation and action of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- , HOXA10 and forkhead transcription factor-1 -LRB- FOXO-1 -RRB- in the baboon endometrium .
1696886	0	insulin-like_growth_factor_binding_protein-1	32,76	IGFBP-1	78,85	insulin-like growth factor binding protein-1	IGFBP-1	25685(Tax:10116)	25685(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Dexamethasone increases hepatic insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA and serum IGFBP-1 concentrations in the rat .
1713220	0	insulin-like_growth_factor_binding_protein-1	22,66	IGFBP-1	68,75	insulin-like growth factor binding protein-1	IGFBP-1	3484	3484	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Octreotide stimulates insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- levels in acromegaly .
18598121	0	insulin-like_growth_factor_binding_protein-1	44,88	IGFBP-1	90,97	insulin-like growth factor binding protein-1	IGFBP-1	3484	3484	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Evidence supporting proteolytic cleavage of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- protein in amniotic_fluid .
19732896	0	insulin-like_growth_factor_binding_protein-1	6,50	IGFBP-1	52,59	insulin-like growth factor binding protein-1	IGFBP-1	3484	3484	Gene	Gene	status|amod|START_ENTITY status|compound|END_ENTITY	Serum insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- phosphorylation status in subjects with and without ischaemic_heart_disease .
7534144	0	insulin-like_growth_factor_binding_protein-1	14,58	IGFBP-1	60,67	insulin-like growth factor binding protein-1	IGFBP-1	3484	3484	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- in insulin-dependent_diabetes_mellitus .
7683312	0	insulin-like_growth_factor_binding_protein-1	67,111	IGFBP-1	113,120	insulin-like growth factor binding protein-1	IGFBP-1	25685(Tax:10116)	25685(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Interactive effects of nutrients and hormones on the expression of insulin-like_growth_factor_binding_protein-1 -LRB- IGFBP-1 -RRB- mRNA and peptide , and IGF_I release from isolated adult rat hepatocytes .
1375600	0	insulin-like_growth_factor_binding_protein-1	22,66	Insulin	0,7	insulin-like growth factor binding protein-1	Insulin	3484	3630	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Insulin regulation of insulin-like_growth_factor_binding_protein-1 in obese and nonobese humans .
11108281	0	insulin-like_growth_factor_binding_protein-1	44,88	Interleukin-1beta	0,17	insulin-like growth factor binding protein-1	Interleukin-1beta	101026642	101023446	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces the expression of insulin-like_growth_factor_binding_protein-1 during decidualization in the primate .
18827440	0	insulin-like_growth_factor_binding_protein-1	14,58	aryl_hydrocarbon_receptor	89,114	insulin-like growth factor binding protein-1	aryl hydrocarbon receptor	16006(Tax:10090)	11622(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of insulin-like_growth_factor_binding_protein-1 and lipoprotein_lipase by the aryl_hydrocarbon_receptor .
22358762	0	insulin-like_growth_factor_binding_protein-1	40,84	hIGFBP-1	86,94	insulin-like growth factor binding protein-1	hIGFBP-1	3484	3484	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Stable , recombinant expression of human insulin-like_growth_factor_binding_protein-1 -LRB- hIGFBP-1 -RRB- in Chinese_hamster_ovary -LRB- CHO -RRB- cells .
11445561	0	insulin-like_growth_factor_binding_protein-1	100,144	insulin	45,52	insulin-like growth factor binding protein-1	insulin	3484	3630	Gene	Gene	transcription|amod|START_ENTITY inhibition|nmod|transcription inhibition|nsubj|mechanisms mechanisms|nmod|END_ENTITY	Gene - and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like_growth_factor_binding_protein-1 and phosphoenolpyruvate_carboxykinase transcription .
19164337	0	insulin-like_growth_factor_binding_protein-1	6,50	insulin	96,103	insulin-like growth factor binding protein-1	insulin	3484	3630	Gene	Gene	improvement|dep|START_ENTITY improvement|nmod|indices indices|nmod|sensitivity sensitivity|compound|END_ENTITY	Serum insulin-like_growth_factor_binding_protein-1 : an improvement over other simple indices of insulin sensitivity in the assessment of subjects with normal glucose tolerance .
24056811	0	insulin-like_growth_factor_binding_protein-1	6,50	insulin	84,91	insulin-like growth factor binding protein-1	insulin	3484	3630	Gene	Gene	Delta|nummod|START_ENTITY Delta|dep|marker marker|nmod|resistance resistance|compound|END_ENTITY	Delta insulin-like_growth_factor_binding_protein-1 -LRB- / \ IGFBP-1 -RRB- : a marker of hepatic insulin resistance ?
10965886	0	insulin-like_growth_factor_binding_protein-1	15,59	interleukin-1beta	73,90	insulin-like growth factor binding protein-1	interleukin-1beta	3484	3553	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Stimulation of insulin-like_growth_factor_binding_protein-1 synthesis by interleukin-1beta : requirement of the mitogen-activated protein kinase pathway .
10459849	0	insulin-like_growth_factor_binding_protein-1	18,62	progesterone_receptor	75,96	insulin-like growth factor binding protein-1	progesterone receptor	3484	5241	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Activation of the insulin-like_growth_factor_binding_protein-1 promoter by progesterone_receptor in decidualized human endometrial stromal cells .
8905638	0	insulin-like_growth_factor_binding_protein-2	43,87	Growth_hormone	0,14	insulin-like growth factor binding protein-2	Growth hormone	443469(Tax:9940)	443329(Tax:9940)	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Growth_hormone stimulates the secretion of insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- by monolayer cultures of sheep costal growth plate chondrocytes .
10372962	0	insulin-like_growth_factor_binding_protein-2	51,95	IGFBP-2	97,104	insulin-like growth factor binding protein-2	IGFBP-2	25662(Tax:10116)	25662(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cell-density -LRB- cycle -RRB- dependent silencer of the rat insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- gene .
8624265	0	insulin-like_growth_factor_binding_protein-2	10,54	IGFBP-2	56,63	insulin-like growth factor binding protein-2	IGFBP-2	3485	3485	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Increased insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- gene expression and protein production lead to high IGFBP-2 content in malignant ovarian_cyst fluid .
8817676	0	insulin-like_growth_factor_binding_protein-2	29,73	IGFBP-2	75,82	insulin-like growth factor binding protein-2	IGFBP-2	25662(Tax:10116)	25662(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Cell membrane association of insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- in the rat brain olfactory bulb .
9741833	0	insulin-like_growth_factor_binding_protein-2	34,78	IGFBP-2	80,87	insulin-like growth factor binding protein-2	IGFBP-2	3485	3485	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A distal regulatory region of the insulin-like_growth_factor_binding_protein-2 -LRB- IGFBP-2 -RRB- gene interacts with the basic helix-loop-helix transcription factor , AP-4 .
24942865	0	insulin-like_growth_factor_binding_protein-3	52,96	Akt3	100,104	insulin-like growth factor binding protein-3	Akt3	3486	10000	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional and posttranslational regulation of insulin-like_growth_factor_binding_protein-3 by Akt3 .
7693512	0	insulin-like_growth_factor_binding_protein-3	92,136	Growth_hormone	0,14	insulin-like growth factor binding protein-3	Growth hormone	24484(Tax:10116)	81668(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Growth_hormone , but not insulin-like growth factor I , induces a serum protease activity for insulin-like_growth_factor_binding_protein-3 in hypophysectomized rats in vivo .
12599210	0	insulin-like_growth_factor_binding_protein-3	8,52	IGFBP-3	54,61	insulin-like growth factor binding protein-3	IGFBP-3	3486	3486	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in the differentiation of primary human adult skeletal myoblasts .
15817480	0	insulin-like_growth_factor_binding_protein-3	104,148	IGFBP-3	150,157	insulin-like growth factor binding protein-3	IGFBP-3	3486	3486	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a novel positive transcription regulatory element that differentially regulates the insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- gene in senescent cells .
9077473	0	insulin-like_growth_factor_binding_protein-3	14,58	IGFBP-3	60,67	insulin-like growth factor binding protein-3	IGFBP-3	3486	3486	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- in the psoriatic_lesion .
9699724	0	insulin-like_growth_factor_binding_protein-3	29,73	IGFBP-3	75,82	insulin-like growth factor binding protein-3	IGFBP-3	3486	3486	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Intranuclear localization of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- during cell division in human keratinocytes .
19341330	0	insulin-like_growth_factor_binding_protein-3	71,115	IGFBP3	117,123	insulin-like growth factor binding protein-3	IGFBP3	16009(Tax:10090)	16009(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Estradiol , progesterone , and transforming_growth_factor_alpha regulate insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- expression in mouse endometrial cells .
24809065	0	insulin-like_growth_factor_binding_protein-3	58,102	IGFBP3	104,110	insulin-like growth factor binding protein-3	IGFBP3	3486	3486	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Maximal oxygen uptake is associated with allele -202 A of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- promoter polymorphism and -LRB- CA -RRB- n tandem repeats of insulin-like growth factor IGF1 in Caucasians from Poland .
16331609	0	insulin-like_growth_factor_binding_protein-3	30,74	Insulin-like_growth_factor-I	0,28	insulin-like growth factor binding protein-3	Insulin-like growth factor-I	3486	3479	Gene	Gene	risk|amod|START_ENTITY END_ENTITY|appos|risk	Insulin-like_growth_factor-I , insulin-like_growth_factor_binding_protein-3 and the risk of fibrocystic_breast_conditions among Chinese women .
22008548	0	insulin-like_growth_factor_binding_protein-3	42,86	Mxi1	0,4	insulin-like growth factor binding protein-3	Mxi1	16009(Tax:10090)	17859(Tax:10090)	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Mxi1 regulates cell proliferation through insulin-like_growth_factor_binding_protein-3 .
22900087	0	insulin-like_growth_factor_binding_protein-3	32,76	Syndecan-2	0,10	insulin-like growth factor binding protein-3	Syndecan-2	3486	6383	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Syndecan-2 is a novel target of insulin-like_growth_factor_binding_protein-3 and is over-expressed in fibrosis .
10670759	0	insulin-like_growth_factor_binding_protein-3	26,70	growth_hormone	99,113	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	proteolysis|nmod|START_ENTITY Absence|nmod|proteolysis Absence|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Absence of proteolysis of insulin-like_growth_factor_binding_protein-3 in serum from patients with growth_hormone deficiency .
1284115	0	insulin-like_growth_factor_binding_protein-3	44,88	growth_hormone	116,130	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	measurement|nmod|START_ENTITY Usefulness|nmod|measurement Usefulness|nmod|diagnosis diagnosis|nmod|deficiency deficiency|amod|END_ENTITY	Usefulness and limitation of measurement of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- for diagnosis of growth_hormone deficiency .
12901539	0	insulin-like_growth_factor_binding_protein-3	26,70	growth_hormone	99,113	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Diagnostic value of serum insulin-like_growth_factor_binding_protein-3 in children with or without growth_hormone deficiency .
18984657	0	insulin-like_growth_factor_binding_protein-3	21,65	growth_hormone	174,188	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	polymorphism|amod|START_ENTITY allele|nmod|polymorphism associated|nsubjpass|allele associated|xcomp|END_ENTITY	The -202 A allele of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- promoter polymorphism is associated with higher IGFBP-3 serum levels and better growth response to growth_hormone treatment in patients with severe growth_hormone deficiency .
18984657	0	insulin-like_growth_factor_binding_protein-3	21,65	growth_hormone	223,237	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	polymorphism|amod|START_ENTITY allele|nmod|polymorphism associated|nsubjpass|allele associated|xcomp|growth_hormone growth_hormone|nmod|patients patients|nmod|deficiency deficiency|compound|END_ENTITY	The -202 A allele of insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP3 -RRB- promoter polymorphism is associated with higher IGFBP-3 serum levels and better growth response to growth_hormone treatment in patients with severe growth_hormone deficiency .
21648284	0	insulin-like_growth_factor_binding_protein-3	12,56	growth_hormone	76,90	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	proteolysis|amod|START_ENTITY Evidence|nmod|proteolysis Evidence|nmod|testing testing|amod|END_ENTITY	Evidence of insulin-like_growth_factor_binding_protein-3 proteolysis during growth_hormone stimulation testing .
24927347	0	insulin-like_growth_factor_binding_protein-3	80,124	growth_hormone	33,47	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Age related secretary pattern of growth_hormone , insulin-like growth factor-I _ insulin-like_growth_factor_binding_protein-3 in postmenopausal women .
7518726	0	insulin-like_growth_factor_binding_protein-3	20,64	growth_hormone	130,144	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	START_ENTITY|nmod|evaluation evaluation|nmod|children children|nmod|END_ENTITY	Clinical utility of insulin-like_growth_factor_binding_protein-3 in the evaluation and treatment of short children with suspected growth_hormone deficiency .
7545763	0	insulin-like_growth_factor_binding_protein-3	53,97	growth_hormone	27,41	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Adjuvant recombinant human growth_hormone stimulates insulin-like_growth_factor_binding_protein-3 secretion in critically ill trauma patients .
9543142	0	insulin-like_growth_factor_binding_protein-3	37,81	growth_hormone	13,27	insulin-like growth factor binding protein-3	growth hormone	3486	2688	Gene	Gene	proteolysis|amod|START_ENTITY effect|nmod|proteolysis effect|nmod|END_ENTITY	No effect of growth_hormone on serum insulin-like_growth_factor_binding_protein-3 proteolysis .
19258508	0	insulin-like_growth_factor_binding_protein-3	31,75	insulin-like_growth_factor-I	87,115	insulin-like growth factor binding protein-3	insulin-like growth factor-I	3486	3479	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	NKX3 .1 activates expression of insulin-like_growth_factor_binding_protein-3 to mediate insulin-like_growth_factor-I signaling and cell proliferation .
14734476	0	insulin-like_growth_factor_binding_protein-3	105,149	vascular_endothelial_growth_factor	168,202	insulin-like growth factor binding protein-3	vascular endothelial growth factor	16009(Tax:10090)	22339(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	In vivo suppression of hormone-refractory_prostate_cancer growth by inositol_hexaphosphate : induction of insulin-like_growth_factor_binding_protein-3 and inhibition of vascular_endothelial_growth_factor .
11380497	0	insulin-like_growth_factor_binding_protein-4	17,61	IGFBP-4	63,70	insulin-like growth factor binding protein-4	IGFBP-4	3487	3487	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Plasma levels of insulin-like_growth_factor_binding_protein-4 -LRB- IGFBP-4 -RRB- under normal and pathological conditions .
9359468	0	insulin-like_growth_factor_binding_protein-4	44,88	IGFBP-4	90,97	insulin-like growth factor binding protein-4	IGFBP-4	360622(Tax:10116)	360622(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transforming_growth_factor-alpha stimulates insulin-like_growth_factor_binding_protein-4 -LRB- IGFBP-4 -RRB- expression and blocks follicle-stimulating hormone regulation of IGFBP-4 production in rat granulosa cells .
21274331	0	insulin-like_growth_factor_binding_protein-4	12,56	parathyroid_hormone	87,106	Insulin-like growth factor binding protein-4	parathyroid hormone	3487	5741	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Circulating insulin-like_growth_factor_binding_protein-4 -LRB- IGFBP-4 -RRB- is not regulated by parathyroid_hormone and vitamin_D in vivo : evidence from children with rickets .
7559606	0	insulin-like_growth_factor_binding_protein-5	42,86	AP-2	21,25	insulin-like growth factor binding protein-5	AP-2	3488	7020	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor AP-2 regulates human insulin-like_growth_factor_binding_protein-5 gene expression .
10218991	0	insulin-like_growth_factor_binding_protein-5	31,75	Androgen_receptor	0,17	insulin-like growth factor binding protein-5	Androgen receptor	3488	367	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Androgen_receptor up-regulates insulin-like_growth_factor_binding_protein-5 -LRB- IGFBP-5 -RRB- expression in a human prostate_cancer xenograft .
10218991	0	insulin-like_growth_factor_binding_protein-5	31,75	IGFBP-5	77,84	insulin-like growth factor binding protein-5	IGFBP-5	3488	3488	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen_receptor up-regulates insulin-like_growth_factor_binding_protein-5 -LRB- IGFBP-5 -RRB- expression in a human prostate_cancer xenograft .
11960310	0	insulin-like_growth_factor_binding_protein-5	33,77	IGFBP5	79,85	insulin-like growth factor binding protein-5	IGFBP5	3488	3488	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The IDDM13 region containing the insulin-like_growth_factor_binding_protein-5 -LRB- IGFBP5 -RRB- gene on chromosome 2q33-q36 and the genetic susceptibility to rheumatoid_arthritis .
19332648	0	insulin-like_growth_factor_binding_protein-5	27,71	Igfbp5	73,79	insulin-like growth factor binding protein-5	Igfbp5	16011(Tax:10090)	16011(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	IGF-independent effects of insulin-like_growth_factor_binding_protein-5 -LRB- Igfbp5 -RRB- in vivo .
15956342	0	insulin-like_growth_factor_binding_protein-5	18,62	parathyroid_hormone	75,94	insulin-like growth factor binding protein-5	parathyroid hormone	25285(Tax:10116)	24694(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Activation of the insulin-like_growth_factor_binding_protein-5 promoter by parathyroid_hormone in osteosarcoma cells requires activation of an activated protein-2 element .
7678342	0	insulin-like_growth_factor_binding_protein_1	35,79	HNF1	121,125	insulin-like growth factor binding protein 1	HNF1	3484	6927	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Liver-specific expression of human insulin-like_growth_factor_binding_protein_1 : functional role of transcription factor HNF1 in vivo .
14617774	0	insulin-like_growth_factor_binding_protein_2	10,54	IGFBP-2	56,63	insulin-like growth factor binding protein 2	IGFBP-2	3485	3485	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	IIp45 , an insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- binding protein , antagonizes IGFBP-2 stimulation of glioma_cell_invasion .
7526357	0	insulin-like_growth_factor_binding_protein_2	14,58	IGFBP-2	60,67	insulin-like growth factor binding protein 2	IGFBP-2	3485	3485	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of insulin-like_growth_factor_binding_protein_2 -LRB- IGFBP-2 -RRB- in Wilms ' _ tumors .
20150439	0	insulin-like_growth_factor_binding_protein_2	8,52	caspase-3	118,127	insulin-like growth factor binding protein 2	caspase-3	3485	836	Gene	Gene	Role|nmod|START_ENTITY Role|dep|effect effect|nmod|END_ENTITY	Role of insulin-like_growth_factor_binding_protein_2 in lung_adenocarcinoma : IGF-independent antiapoptotic effect via caspase-3 .
25553725	0	insulin-like_growth_factor_binding_protein_3	19,63	IGFBP-3	65,72	insulin-like growth factor binding protein 3	IGFBP-3	3486	3486	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of the insulin-like_growth_factor_binding_protein_3 -LRB- IGFBP-3 -RRB- polymorphism with longevity in Chinese nonagenarians and centenarians .
10714634	0	insulin-like_growth_factor_binding_protein_3	49,93	Insulin-like_growth_factor_I	0,28	insulin-like growth factor binding protein 3	Insulin-like growth factor I	24484(Tax:10116)	24482(Tax:10116)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Insulin-like_growth_factor_I in combination with insulin-like_growth_factor_binding_protein_3 affects the hepatic acute phase response and hepatic morphology in thermally injured rats .
9615225	0	insulin-like_growth_factor_binding_protein_4	52,96	IGFBP4	103,109	insulin-like growth factor binding protein 4	IGFBP4	3487	3487	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and transcription regulation of the human insulin-like_growth_factor_binding_protein_4 gene -LRB- IGFBP4 -RRB- .
22500655	0	insulin-like_growth_factor_mRNA-binding_protein_3	5,54	IMP3	56,60	insulin-like growth factor mRNA-binding protein 3	IMP3	55272	55272	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	High insulin-like_growth_factor_mRNA-binding_protein_3 -LRB- IMP3 -RRB- protein expression is associated with poor survival in muscle-invasive bladder_cancer .
19778024	0	insulin-like_growth_factor_receptor	89,124	IGF-1R	126,132	insulin-like growth factor receptor	IGF-1R	3480	3480	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Discovery of a 2,4-disubstituted _ pyrrolo -LSB- 1,2-f -RSB- -LSB- 1,2,4 -RSB- triazine inhibitor -LRB- BMS-754807 -RRB- of insulin-like_growth_factor_receptor -LRB- IGF-1R -RRB- kinase in clinical development .
21695430	0	insulin-like_growth_factor_receptor	128,163	IGF1R	165,170	insulin-like growth factor receptor	IGF1R	397350(Tax:9823)	397350(Tax:9823)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Study of the differential transcription in liver of growth_hormone_receptor -LRB- GHR -RRB- , insulin-like growth factors -LRB- IGF1 , IGF2 -RRB- and insulin-like_growth_factor_receptor -LRB- IGF1R -RRB- genes at different postnatal developmental ages in pig breeds .
9496257	0	insulin-like_growth_factor_receptor_1	24,61	IGFR-1	63,69	insulin-like growth factor receptor 1	IGFR-1	100132417	100132417	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	The localization of the insulin-like_growth_factor_receptor_1 -LRB- IGFR-1 -RRB- in benign and malignant breast tissue .
10594701	0	insulin-like_growth_factor_type-2_receptor	66,108	cation-independent_mannose_6-phosphate_receptor	18,65	insulin-like growth factor type-2 receptor	cation-independent mannose 6-phosphate receptor	3482	3482	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of cation-independent_mannose_6-phosphate_receptor / insulin-like_growth_factor_type-2_receptor as a novel target of autoantibodies .
23729566	0	insulin-like_peptide_3	24,46	INSL3	48,53	insulin-like peptide 3	INSL3	100861214	100861214	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	The active form of goat insulin-like_peptide_3 -LRB- INSL3 -RRB- is a single-chain structure comprising three domains B-C-A , constitutively expressed and secreted by testicular Leydig cells .
23934571	0	insulin-like_peptide_3	24,46	INSL3	48,53	insulin-like peptide 3	INSL3	100861214	100861214	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	The active form of goat insulin-like_peptide_3 -LRB- INSL3 -RRB- is a single-chain structure comprising three domains B-C-A , constitutively expressed and secreted by testicular Leydig cells .
16467492	0	insulin-like_peptide_3	18,40	LGR8	67,71	insulin-like peptide 3	LGR8	3640	122042	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Expression of the insulin-like_peptide_3 -LRB- INSL3 -RRB- hormone-receptor -LRB- LGR8 -RRB- system in the testis .
21899516	0	insulin-like_peptide_3	26,48	RLF	21,24	insulin-like peptide 3	RLF	3640	6018	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Relaxin-like factor -LRB- RLF -RRB- / insulin-like_peptide_3 -LRB- INSL3 -RRB- is secreted from testicular Leydig cells as a monomeric protein comprising three domains B-C-A with full biological activity in boars .
26220663	0	insulin-like_peptide_3	23,45	RXFP2	47,52	insulin-like peptide 3	RXFP2	403436(Tax:9615)	450220(Tax:9615)	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Expression analyses of insulin-like_peptide_3 , RXFP2 , LH receptor , and 3b-hydroxysteroid dehydrogenase in testes of normal and cryptorchid dogs .
26220663	0	insulin-like_peptide_3	23,45	RXFP2	47,52	insulin-like peptide 3	RXFP2	403436(Tax:9615)	450220(Tax:9615)	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Expression analyses of insulin-like_peptide_3 , RXFP2 , LH receptor , and 3b-hydroxysteroid dehydrogenase in testes of normal and cryptorchid dogs .
16467492	0	insulin-like_peptide_3	18,40	hormone-receptor	49,65	insulin-like peptide 3	hormone-receptor	3640	3164	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Expression of the insulin-like_peptide_3 -LRB- INSL3 -RRB- hormone-receptor -LRB- LGR8 -RRB- system in the testis .
19647771	0	insulin-regulated_aminopeptidase	38,70	IRAP	72,76	insulin-regulated aminopeptidase	IRAP	240028(Tax:10090)	240028(Tax:10090)	Gene	Gene	behavior|nmod|START_ENTITY behavior|appos|END_ENTITY	Reproduction and maternal behavior in insulin-regulated_aminopeptidase -LRB- IRAP -RRB- knockout mice .
21476495	0	insulin-regulated_aminopeptidase	33,65	IRAP	67,71	insulin-regulated aminopeptidase	IRAP	4012	4012	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|appos|END_ENTITY	Potent macrocyclic inhibitors of insulin-regulated_aminopeptidase -LRB- IRAP -RRB- by olefin ring-closing metathesis .
21679152	0	insulin-regulated_aminopeptidase	46,78	IRAP	80,84	insulin-regulated aminopeptidase	IRAP	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Alpha-1-adrenergic receptor blockade modifies insulin-regulated_aminopeptidase -LRB- IRAP -RRB- activity in rat prostate and modulates oxytocin functions .
12061804	0	insulin-responsive_aminopeptidase	37,70	Protein_kinase_C-zeta	0,21	insulin-responsive aminopeptidase	Protein kinase C-zeta	171105(Tax:10116)	25522(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Protein_kinase_C-zeta phosphorylates insulin-responsive_aminopeptidase in vitro at Ser-80 and Ser-91 .
15182197	0	insulin-responsive_glucose_transporter	24,62	EHD2	0,4	insulin-responsive glucose transporter	EHD2	25139(Tax:10116)	361512(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	EHD2 interacts with the insulin-responsive_glucose_transporter -LRB- GLUT4 -RRB- in rat adipocytes and may participate in insulin-induced GLUT4 recruitment .
8710883	0	insulin-responsive_glucose_transporter	97,135	GLUT4	137,142	insulin-responsive glucose transporter	GLUT4	25139(Tax:10116)	25139(Tax:10116)	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Evidence for an insulin_receptor_substrate_1 independent insulin signaling pathway that mediates insulin-responsive_glucose_transporter -LRB- GLUT4 -RRB- translocation .
3517163	0	insulin_and_insulin-like_growth_factor-1	23,63	IGF1	65,69	insulin and insulin-like growth factor-1	IGF1	3630;3479	3479	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Suppressive effects of insulin_and_insulin-like_growth_factor-1 -LRB- IGF1 -RRB- on immune responses .
12715277	0	insulin_and_insulin-like_growth_factor-I	11,51	renin	55,60	insulin and insulin-like growth factor-I	renin	3630	5972	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of insulin_and_insulin-like_growth_factor-I on renin gene expression in the renal cortical cells of ovine fetuses .
22036964	0	insulin_degrading_enzyme	49,73	HES-1	25,30	insulin degrading enzyme	HES-1	3416	3280	Gene	Gene	bind|acl|START_ENTITY bind|amod|END_ENTITY	Notch signaling proteins HES-1 and Hey-1 bind to insulin_degrading_enzyme -LRB- IDE -RRB- proximal promoter and repress its transcription and activity : implications for cellular Ab metabolism .
10435054	0	insulin_like_growth_factor-1	78,106	IGF-1	108,113	insulin like growth factor-1	IGF-1	3479	3479	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Peak and trough growth_hormone -LRB- GH -RRB- concentrations influence growth and serum insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- concentrations in short children .
23397157	0	insulin_like_growth_factor-1	80,108	IGF-1	110,115	insulin like growth factor-1	IGF-1	24482(Tax:10116)	24482(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	The effects of induced type-I diabetes on developmental regulation of insulin _ insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- receptors in the cerebellum of rat neonates .
17619941	0	insulin_like_growth_factor-1	86,114	basic_fibroblast_growth_factor	47,77	insulin like growth factor-1	basic fibroblast growth factor	3479	2247	Gene	Gene	release|appos|START_ENTITY release|nmod|END_ENTITY	Effects of laser irradiation on the release of basic_fibroblast_growth_factor -LRB- bFGF -RRB- , insulin_like_growth_factor-1 -LRB- IGF-1 -RRB- , and receptor of IGF-1 -LRB- IGFBP3 -RRB- from gingival fibroblasts .
1716700	0	insulin_like_growth_factor-binding_protein_3	18,62	IGFBP-3	64,71	insulin like growth factor-binding protein 3	IGFBP-3	3486	3486	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the insulin_like_growth_factor-binding_protein_3 -LRB- IGFBP-3 -RRB- gene is increased in human renal_carcinomas .
10545531	0	insulin_promoter_factor-1	27,52	IPF-1	54,59	insulin promoter factor-1	IPF-1	3651	3651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Defective mutations in the insulin_promoter_factor-1 -LRB- IPF-1 -RRB- gene in late-onset type_2_diabetes_mellitus .
8635654	0	insulin_promoter_factor_1	66,91	IPF-1	93,98	insulin promoter factor 1	IPF-1	3651	3651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation , characterization , and chromosomal mapping of the human insulin_promoter_factor_1 -LRB- IPF-1 -RRB- gene .
17003361	0	insulin_promoter_factor_1	35,60	IPF1	62,66	insulin promoter factor 1	IPF1	3651	3651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of a proline insertion in the insulin_promoter_factor_1 -LRB- IPF1 -RRB- gene in African Americans with type 2 diabetes .
7490099	0	insulin_promoter_factor_1	15,40	Ipf1	47,51	insulin promoter factor 1	Ipf1	18609(Tax:10090)	18609(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the insulin_promoter_factor_1 gene -LRB- Ipf1 -RRB- to distal mouse chromosome 5 .
15694368	0	insulin_receptor	72,88	AICAR	0,5	insulin receptor	AICAR	3643	471	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	AICAR , an activator of AMP-activated protein kinase , down-regulates the insulin_receptor expression in HepG2 cells .
21841811	0	insulin_receptor	43,59	Activating_transcription_factor_6	0,33	insulin receptor	Activating transcription factor 6	3643	22926	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Activating_transcription_factor_6 protects insulin_receptor from ER stress-stimulated desensitization via p42/44 ERK pathway .
12431980	0	insulin_receptor	42,58	Annexin_II	13,23	insulin receptor	Annexin II	16337(Tax:10090)	12306(Tax:10090)	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|END_ENTITY	Secretion of Annexin_II via activation of insulin_receptor and insulin-like growth factor receptor .
8557683	0	insulin_receptor	81,97	CD45	47,51	insulin receptor	CD45	3643	5788	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin_receptor signaling .
17563366	0	insulin_receptor	43,59	Calreticulin	0,12	insulin receptor	Calreticulin	3643	811	Gene	Gene	stabilize|dobj|START_ENTITY stabilize|nsubj|END_ENTITY	Calreticulin and Hsp90 stabilize the human insulin_receptor and promote its mobility in the endoplasmic reticulum .
18840478	0	insulin_receptor	23,39	Calreticulin	0,12	insulin receptor	Calreticulin	16337(Tax:10090)	12317(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Calreticulin regulates insulin_receptor expression and its downstream PI3 Kinase/Akt signalling pathway .
10598578	0	insulin_receptor	30,46	Caveolin-1	0,10	insulin receptor	Caveolin-1	24954(Tax:10116)	857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Caveolin-1 interacts with the insulin_receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells .
16731820	0	insulin_receptor	32,48	Foxo1	18,23	insulin receptor	Foxo1	16337(Tax:10090)	56458(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Glucose regulates Foxo1 through insulin_receptor signaling in the pancreatic islet beta-cell .
8863182	0	insulin_receptor	24,40	GLUT_1	108,114	insulin receptor	GLUT 1	24954(Tax:10116)	24778(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Dexamethasone modulates insulin_receptor expression and subcellular distribution of the glucose transporter GLUT_1 in UMR 106-01 , a clonal osteogenic_sarcoma cell line .
22751693	0	insulin_receptor	63,79	Glypican-4	0,10	insulin receptor	Glypican-4	3643	2239	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Glypican-4 enhances insulin signaling via interaction with the insulin_receptor and serves as a novel adipokine .
12493740	0	insulin_receptor	173,189	Grb10	0,5	insulin receptor	Grb10	3643	2887	Gene	Gene	IRS-2|nmod|START_ENTITY association|nmod|IRS-2 disrupting|dobj|association signaling|advcl|disrupting 3-kinase/Akt|acl|signaling substrate|dep|3-kinase/Akt substrate|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
12493740	0	insulin_receptor	34,50	Grb10	0,5	insulin receptor	Grb10	3643	2887	Gene	Gene	substrate|compound|START_ENTITY substrate|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
16434550	0	insulin_receptor	53,69	Grb10	0,5	insulin receptor	Grb10	3643	2887	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|insulin-stimulated insulin-stimulated|nmod:npmod|mediates mediates|nummod|END_ENTITY	Grb10 mediates insulin-stimulated degradation of the insulin_receptor : a mechanism of negative regulation .
9506989	0	insulin_receptor	40,56	Grb10	0,5	insulin receptor	Grb10	3643	2887	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Grb10 interacts differentially with the insulin_receptor , insulin-like growth factor I receptor , and epidermal_growth_factor_receptor via the Grb10 Src homology 2 -LRB- SH2 -RRB- domain and a second novel domain located between the pleckstrin homology and SH2 domains .
17434141	0	insulin_receptor	21,37	HMGA1	67,72	insulin receptor	HMGA1	3643	3159	Gene	Gene	START_ENTITY|advcl|impairing impairing|dobj|END_ENTITY	Fatty_acid represses insulin_receptor gene expression by impairing HMGA1 through protein kinase Cepsilon .
17510394	0	insulin_receptor	32,48	HMGA1	0,5	insulin receptor	HMGA1	3643	3159	Gene	Gene	transcription|nmod|START_ENTITY controls|dobj|transcription controls|nsubj|END_ENTITY	HMGA1 controls transcription of insulin_receptor to regulate cyclin_D1 translation in pancreatic_cancer cells .
22355763	0	insulin_receptor	50,66	HMGA1	0,5	insulin receptor	HMGA1	3643	3159	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	HMGA1 is a novel downstream nuclear target of the insulin_receptor signaling pathway .
23935097	0	insulin_receptor	24,40	IGF-1R	85,91	insulin receptor	IGF-1R	3643	3480	Gene	Gene	/|nsubj|START_ENTITY /|dobj|receptor receptor|appos|END_ENTITY	A highly selective dual insulin_receptor -LRB- IR -RRB- / insulin-like growth factor 1 receptor -LRB- IGF-1R -RRB- inhibitor derived from an extracellular_signal-regulated_kinase -LRB- ERK -RRB- inhibitor .
9284058	0	insulin_receptor	63,79	IGF-I	33,38	insulin receptor	IGF-I	24954(Tax:10116)	24482(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Distribution Distribution|nmod|END_ENTITY	Distribution and levels of -LSB- 125I -RSB- IGF-I , -LSB- 125I -RSB- IGF-II and -LSB- 125I -RSB- insulin_receptor binding sites in the hippocampus of aged memory-unimpaired and - impaired rats .
17556377	0	insulin_receptor	94,110	IGF-II	0,6	insulin receptor	IGF-II	3643	3481	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin_receptor .
9281335	0	insulin_receptor	48,64	IGF-II	32,38	insulin receptor	IGF-II	16337(Tax:10090)	16002(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Growth-promoting interaction of IGF-II with the insulin_receptor during mouse embryonic development .
19170714	0	insulin_receptor	98,114	IR	116,118	insulin receptor	IR	3643	3643	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulin_receptor -LRB- IR -RRB- gene .
11484076	0	insulin_receptor	164,180	IRS-1	194,199	insulin receptor	IRS-1	24954(Tax:10116)	25467(Tax:10116)	Gene	Gene	START_ENTITY|nmod|that that|nmod|END_ENTITY	Insulin-independent and wortmannin-resistant targeting of IRS-3 to the plasma membrane via its pleckstrin homology domain mediates a different interaction with the insulin_receptor from that of IRS-1 .
12493740	0	insulin_receptor	173,189	IRS-1	152,157	insulin receptor	IRS-1	3643	3667	Gene	Gene	IRS-2|nmod|START_ENTITY IRS-2|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
12493740	0	insulin_receptor	34,50	IRS-1	152,157	insulin receptor	IRS-1	3643	3667	Gene	Gene	substrate|compound|START_ENTITY substrate|dep|3-kinase/Akt 3-kinase/Akt|acl|signaling signaling|advcl|disrupting disrupting|dobj|association association|nmod|IRS-2 IRS-2|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
15069075	0	insulin_receptor	132,148	IRS-1	89,94	insulin receptor	IRS-1	3643	3667	Gene	Gene	interaction|nmod|START_ENTITY attenuates|dobj|interaction attenuates|nsubj|phosphorylation phosphorylation|nmod|Ser318 Ser318|nmod|insulin_receptor_substrate-1 insulin_receptor_substrate-1|appos|END_ENTITY	Protein_kinase_C-zeta-induced phosphorylation of Ser318 in insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- attenuates the interaction with the insulin_receptor and the tyrosine phosphorylation of IRS-1 .
15590636	0	insulin_receptor	97,113	IRS-1	36,41	insulin receptor	IRS-1	3643	3667	Gene	Gene	causes|nmod|START_ENTITY causes|nsubj|G972R G972R|compound|END_ENTITY	Human insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- polymorphism G972R causes IRS-1 to associate with the insulin_receptor and inhibit receptor autophosphorylation .
15590636	0	insulin_receptor	97,113	IRS-1	69,74	insulin receptor	IRS-1	3643	3667	Gene	Gene	causes|nmod|START_ENTITY causes|xcomp|END_ENTITY	Human insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- polymorphism G972R causes IRS-1 to associate with the insulin_receptor and inhibit receptor autophosphorylation .
7593251	0	insulin_receptor	65,81	IRS-1	119,124	insulin receptor	IRS-1	3643	3667	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Combination of insulinomimetic agents H2O2 and vanadate enhances insulin_receptor mediated tyrosine phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase .
7593251	0	insulin_receptor	65,81	IRS-1	136,141	insulin receptor	IRS-1	3643	3667	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|IRS-1 IRS-1|acl|leading leading|nmod|association association|compound|END_ENTITY	Combination of insulinomimetic agents H2O2 and vanadate enhances insulin_receptor mediated tyrosine phosphorylation of IRS-1 leading to IRS-1 association with the phosphatidylinositol 3-kinase .
7999100	0	insulin_receptor	22,38	IRS-1	97,102	insulin receptor	IRS-1	3643	3667	Gene	Gene	overexpression|nmod|START_ENTITY makes|nsubj|overexpression makes|parataxis|role role|nmod|END_ENTITY	The overexpression of insulin_receptor makes CHO cells resistant to the action of IGF-1 : role of IRS-1 .
8349691	0	insulin_receptor	23,39	IRS-1	50,55	insulin receptor	IRS-1	24954(Tax:10116)	25467(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY substrate|nsubj|Phosphorylation substrate|dobj|END_ENTITY	Phosphorylation of the insulin_receptor substrate IRS-1 by casein kinase II .
8549754	0	insulin_receptor	52,68	IRS-1	96,101	insulin receptor	IRS-1	24954(Tax:10116)	25467(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Glucose - and insulin-induced phosphorylation of the insulin_receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets .
8646778	0	insulin_receptor	75,91	IRS-1	17,22	insulin receptor	IRS-1	3643	3667	Gene	Gene	region|nmod|START_ENTITY bound|nmod|region bound|nsubj|Structure Structure|nmod|domain domain|compound|END_ENTITY	Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin_receptor .
9346913	0	insulin_receptor	68,84	IRS-1	55,60	insulin receptor	IRS-1	3643	3667	Gene	Gene	do|nmod|START_ENTITY do|dobj|END_ENTITY	Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin_receptor .
9368067	1	insulin_receptor	161,177	IRS-1	87,92	insulin receptor	IRS-1	24954(Tax:10116)	25467(Tax:10116)	Gene	Gene	region|nmod|START_ENTITY inhibits|dobj|region inhibits|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin_receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation .
11158333	0	insulin_receptor	142,158	LAR	70,73	insulin receptor	LAR	3643	5792	Gene	Gene	dephosphorylation|nmod|START_ENTITY tyrosine|nmod|dephosphorylation tyrosine|dobj|domains domains|nmod|END_ENTITY	Distinct functions of the two protein tyrosine phosphatase domains of LAR -LRB- leukocyte common antigen-related -RRB- on tyrosine dephosphorylation of insulin_receptor .
7769120	0	insulin_receptor	100,116	LAR	70,73	insulin receptor	LAR	3643	5792	Gene	Gene	accounts|nmod|START_ENTITY accounts|nsubj|abundance abundance|nmod|END_ENTITY	Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin_receptor dephosphorylating activity in adipose tissue of obese human subjects .
8995282	0	insulin_receptor	35,51	LAR	103,106	insulin receptor	LAR	3643	5792	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	Functional association between the insulin_receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells .
9023010	0	insulin_receptor	15,31	LAR	97,100	insulin receptor	LAR	24954(Tax:10116)	360406(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY Suppression|nmod|activation END_ENTITY|nsubj|Suppression	Suppression of insulin_receptor activation by overexpression of the protein-tyrosine phosphatase LAR in hepatoma cells .
9207225	0	insulin_receptor	59,75	LAR	33,36	insulin receptor	LAR	24954(Tax:10116)	360406(Tax:10116)	Gene	Gene	dephosphorylation|compound|START_ENTITY impact|nmod|dephosphorylation has|dobj|impact has|nsubj|END_ENTITY	The protein tyrosine phosphatase LAR has a major impact on insulin_receptor dephosphorylation .
21444687	0	insulin_receptor	31,47	Munc18c	0,7	insulin receptor	Munc18c	3643	6814	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Munc18c phosphorylation by the insulin_receptor links cell signaling directly to SNARE exocytosis .
15677494	0	insulin_receptor	32,48	NPP1	65,69	insulin receptor	NPP1	3643	5167	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Increased hepatic levels of the insulin_receptor inhibitor , PC-1 / NPP1 , induce insulin resistance and glucose_intolerance .
10615944	0	insulin_receptor	41,57	PC-1	22,26	insulin receptor	PC-1	3643	5167	Gene	Gene	function|compound|START_ENTITY inhibition|nmod|function inhibition|compound|END_ENTITY	Membrane glycoprotein PC-1 inhibition of insulin_receptor function occurs via direct interaction with the receptor alpha-subunit .
11289049	0	insulin_receptor	79,95	PC-1	55,59	insulin receptor	PC-1	3643	5122	Gene	Gene	insulin|compound|START_ENTITY interacts|nmod|insulin interacts|nsubj|variant variant|nmod|END_ENTITY	The Q allele variant -LRB- GLN121 -RRB- of membrane glycoprotein PC-1 interacts with the insulin_receptor and inhibits insulin signaling more effectively than the common K allele variant -LRB- LYS121 -RRB- .
15677494	0	insulin_receptor	32,48	PC-1	60,64	insulin receptor	PC-1	3643	5167	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|NPP1 NPP1|compound|END_ENTITY	Increased hepatic levels of the insulin_receptor inhibitor , PC-1 / NPP1 , induce insulin resistance and glucose_intolerance .
19374858	0	insulin_receptor	28,44	PC-1	67,71	insulin receptor	PC-1	3643	5167	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Evidence that inhibition of insulin_receptor signaling activity by PC-1 / ENPP1 is dependent on its enzyme activity .
7673181	0	insulin_receptor	14,30	PC-1	50,54	insulin receptor	PC-1	3643	5167	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Inhibition of insulin_receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine_triphosphate or the generation of adenosine .
9648833	0	insulin_receptor	196,212	PC-1	152,156	insulin receptor	PC-1	3643	5167	Gene	Gene	signaling|compound|START_ENTITY factor|nmod|signaling factor|nsubj|END_ENTITY	Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects : evidence that PC-1 may be an intrinsic factor in impaired insulin_receptor signaling .
14568990	0	insulin_receptor	80,96	PLCgamma1	42,51	insulin receptor	PLCgamma1	3643	5335	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin_receptor .
18492485	0	insulin_receptor	65,81	PRMT1	15,20	insulin receptor	PRMT1	3643	3276	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of PRMT1 in hnRNPQ activation and internalization of insulin_receptor .
26079428	0	insulin_receptor	50,66	PTPRD	0,5	insulin receptor	PTPRD	3643	5789	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	PTPRD silencing by DNA hypermethylation decreases insulin_receptor signaling and leads to type_2_diabetes .
15269244	0	insulin_receptor	48,64	Protein-tyrosine_phosphatase_1B	0,31	insulin receptor	Protein-tyrosine phosphatase 1B	3643	5770	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Protein-tyrosine_phosphatase_1B associates with insulin_receptor and negatively regulates insulin signaling without receptor internalization .
18925540	0	insulin_receptor	77,93	Protein_tyrosine_phosphatase	0,28	insulin receptor	Protein tyrosine phosphatase	3643	26191	Gene	Gene	mutation|compound|START_ENTITY patients|nmod|mutation fibroblasts|nmod|patients END_ENTITY|nmod|fibroblasts	Protein_tyrosine_phosphatase regulation in fibroblasts from patients with an insulin_receptor gene mutation .
8826975	0	insulin_receptor	61,77	Protein_tyrosine_phosphatase_1B	0,31	insulin receptor	Protein tyrosine phosphatase 1B	3643	5770	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protein_tyrosine_phosphatase_1B interacts with the activated insulin_receptor .
17597619	0	insulin_receptor	24,40	Resistin	0,8	insulin receptor	Resistin	3643	56729	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	Resistin down-regulates insulin_receptor expression , and modulates cell viability in rodent pancreatic beta-cells .
10594240	0	insulin_receptor	69,85	SH2-B	56,61	insulin receptor	SH2-B	16337(Tax:10090)	20399(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY END_ENTITY|nmod|domain	Alternative splicing , gene localization , and binding of SH2-B to the insulin_receptor kinase domain .
23515050	0	insulin_receptor	47,63	Signal_regulatory_protein-a	0,27	insulin receptor	Signal regulatory protein-a	16337(Tax:10090)	19261(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Signal_regulatory_protein-a interacts with the insulin_receptor contributing to muscle_wasting in chronic_kidney_disease .
9122188	0	insulin_receptor	42,58	Stat5	0,5	insulin receptor	Stat5	16337(Tax:10090)	20850(Tax:10090)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Stat5 is a physiological substrate of the insulin_receptor .
9428692	0	insulin_receptor	48,64	Stat_5B	18,25	insulin receptor	Stat 5B	3643	6777	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Stat_5B as a substrate of the insulin_receptor .
12612081	0	insulin_receptor	14,30	TCPTP	77,82	insulin receptor	TCPTP	3643	5771	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of insulin_receptor signaling by the protein_tyrosine_phosphatase TCPTP .
7906861	0	insulin_receptor	59,75	alpha_2-HS-glycoprotein	6,29	insulin receptor	alpha 2-HS-glycoprotein	3643	197	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Serum alpha_2-HS-glycoprotein is an inhibitor of the human insulin_receptor at the tyrosine kinase level .
9243097	0	insulin_receptor	29,45	angiotensin_II	11,25	insulin receptor	angiotensin II	3643	24179(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Effects of angiotensin_II on insulin_receptor binding and mRNA levels in normal and diabetic rats .
15870194	0	insulin_receptor	44,60	biliverdin_reductase	6,26	insulin receptor	biliverdin reductase	3643	644	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|dep|member	Human biliverdin_reductase : a member of the insulin_receptor substrate family with serine/threonine/tyrosine kinase activity .
17620332	0	insulin_receptor	65,81	c-Abl	8,13	insulin receptor	c-Abl	16337(Tax:10090)	11350(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of c-Abl in directing metabolic versus mitogenic effects in insulin_receptor signaling .
9447983	0	insulin_receptor	49,65	c-Cbl	24,29	insulin receptor	c-Cbl	3643	867	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	A novel , multifuntional c-Cbl binding protein in insulin_receptor signaling in 3T3-L1 adipocytes .
12036959	0	insulin_receptor	4,20	caveolin-1	63,73	insulin receptor	caveolin-1	3643	857	Gene	Gene	catalyzes|nsubj|START_ENTITY catalyzes|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The insulin_receptor catalyzes the tyrosine phosphorylation of caveolin-1 .
2469133	0	insulin_receptor	92,108	insulin	10,17	insulin receptor	insulin	3643	3630	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of insulin on the growth of a human hepatoma cell line PLC/PRF/5 : a possible role of insulin_receptor .
12493740	0	insulin_receptor	173,189	insulin_receptor	34,50	insulin receptor	insulin receptor	3643	3643	Gene	Gene	IRS-2|nmod|START_ENTITY association|nmod|IRS-2 disrupting|dobj|association signaling|advcl|disrupting 3-kinase/Akt|acl|signaling substrate|dep|3-kinase/Akt substrate|compound|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
12493740	0	insulin_receptor	34,50	insulin_receptor	173,189	insulin receptor	insulin receptor	3643	3643	Gene	Gene	substrate|compound|START_ENTITY substrate|dep|3-kinase/Akt 3-kinase/Akt|acl|signaling signaling|advcl|disrupting disrupting|dobj|association association|nmod|IRS-2 IRS-2|nmod|END_ENTITY	Grb10 inhibits insulin-stimulated insulin_receptor substrate -LRB- IRS -RRB- - phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1 / IRS-2 with the insulin_receptor .
7520127	0	insulin_receptor	14,30	insulin_receptor	32,48	insulin receptor	insulin receptor	3643	3643	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of insulin_receptor , insulin_receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes .
7520127	0	insulin_receptor	32,48	insulin_receptor	14,30	insulin receptor	insulin receptor	3643	3643	Gene	Gene	START_ENTITY|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of insulin_receptor , insulin_receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-F442A adipocytes .
7543044	0	insulin_receptor	34,50	insulin_receptor	82,98	insulin receptor	insulin receptor	100766818	100766818	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	The role of the NPXY motif in the insulin_receptor in tyrosine phosphorylation of insulin_receptor substrate-1 and Shc .
7543044	0	insulin_receptor	82,98	insulin_receptor	34,50	insulin receptor	insulin receptor	100766818	100766818	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|nmod|phosphorylation	The role of the NPXY motif in the insulin_receptor in tyrosine phosphorylation of insulin_receptor substrate-1 and Shc .
9128728	0	insulin_receptor	76,92	insulin_receptor_substrate_1	40,68	insulin receptor	insulin receptor substrate 1	3643	3667	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	In vitro binding and phosphorylation of insulin_receptor_substrate_1 by the insulin_receptor .
10212829	0	insulin_receptor	90,106	lar	61,64	insulin receptor	lar	24954(Tax:10116)	360406(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY tyrosine|nmod|phosphorylation tyrosine|dobj|END_ENTITY	Inhibition of the transmembrane protein tyrosine phosphatase lar by 3S-peptide-I enhances insulin_receptor phosphorylation in intact cells .
8665514	0	insulin_receptor	18,34	p53	81,84	insulin receptor	p53	3643	7157	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Repression of the insulin_receptor promoter by the tumor suppressor gene product p53 : a possible mechanism for receptor overexpression in breast_cancer .
18310298	0	insulin_receptor	4,20	peroxisome_proliferator-activated_receptor-gamma	50,98	insulin receptor	peroxisome proliferator-activated receptor-gamma	3643	5468	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	The insulin_receptor : a new anticancer target for peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- and thiazolidinedione-PPARgamma agonists .
8380406	0	insulin_receptor	50,66	pp120/ecto-ATPase	0,17	insulin receptor	pp120/ecto-ATPase	24954(Tax:10116)	81613(Tax:10116)	Gene	Gene	kinase|compound|START_ENTITY substrate|nmod|kinase END_ENTITY|appos|substrate	pp120/ecto-ATPase , an endogenous substrate of the insulin_receptor tyrosine kinase , is expressed as two variably spliced isoforms .
9244377	0	insulin_receptor	37,53	protein_kinase	15,29	insulin receptor	protein kinase	24954(Tax:10116)	64030(Tax:10116)	Gene	Gene	preparations|compound|START_ENTITY CK2|nmod|preparations CK2|amod|END_ENTITY	Substrates for protein_kinase CK2 in insulin_receptor preparations from rat liver membranes : identification of a 210-kDa protein substrate as the dimeric form of endoplasmin .
12612081	0	insulin_receptor	14,30	protein_tyrosine_phosphatase	48,76	insulin receptor	protein tyrosine phosphatase	3643	26191	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of insulin_receptor signaling by the protein_tyrosine_phosphatase TCPTP .
16828971	0	insulin_receptor	83,99	protein_tyrosine_phosphatase_1B	40,71	insulin receptor	protein tyrosine phosphatase 1B	3643	5770	Gene	Gene	phosphorylation|compound|START_ENTITY enhancing|dobj|phosphorylation inhibit|ccomp|enhancing inhibit|xcomp|END_ENTITY	Ursolic_acid and its derivative inhibit protein_tyrosine_phosphatase_1B , enhancing insulin_receptor phosphorylation and stimulating glucose uptake .
21466649	0	insulin_receptor	53,69	protein_tyrosine_phosphatase_1B	94,125	insulin receptor	protein tyrosine phosphatase 1B	24954(Tax:10116)	24697(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY increasing|dobj|phosphorylation increasing|nmod|regulation regulation|amod|END_ENTITY	Vitamin_A improves insulin sensitivity by increasing insulin_receptor phosphorylation through protein_tyrosine_phosphatase_1B regulation at early age in obese rats of WNIN/Ob strain .
21487008	0	insulin_receptor	127,143	protein_tyrosine_phosphatase_1B	52,83	insulin receptor	protein tyrosine phosphatase 1B	3643	5770	Gene	Gene	precursor|compound|START_ENTITY autoactivation|nmod|precursor reveals|dobj|autoactivation reveals|nsubj|mutant mutant|nmod|END_ENTITY	A new highly efficient substrate-trapping mutant of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- reveals full autoactivation of the insulin_receptor precursor .
10535406	0	insulin_receptor-related_receptor	72,105	IRR	107,110	insulin receptor-related receptor	IRR	3645	3645	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Correlation of type_I_insulin-like_growth factor receptor -LRB- IGF-I-R -RRB- and insulin_receptor-related_receptor -LRB- IRR -RRB- messenger RNA levels in tumor cell lines from pediatric_tumors of neuronal origin .
11025561	0	insulin_receptor_substrate-1	40,68	IRS-1	70,75	insulin receptor substrate-1	IRS-1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular scanning for mutations in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene in Mexican Americans with Type_2_diabetes mellitus .
11317670	0	insulin_receptor_substrate-1	25,53	IRS-1	55,60	insulin receptor substrate-1	IRS-1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The G972R variant of the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene , body fat distribution and insulin-resistance .
15636429	0	insulin_receptor_substrate-1	25,53	IRS-1	55,60	insulin receptor substrate-1	IRS-1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The G972R variant of the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene is associated with insulin resistance in `` uncomplicated '' obese subjects evaluated by hyperinsulinemic-euglycemic_clamp .
16037106	0	insulin_receptor_substrate-1	21,49	IRS-1	51,56	insulin receptor substrate-1	IRS-1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene and the insulin_receptor_substrate-2 -LRB- IRS-2 -RRB- gene influence glucose homeostasis and body mass index in women with polycystic_ovary_syndrome and non-hyperandrogenic controls .
16284438	0	insulin_receptor_substrate-1	40,68	IRS-1	70,75	insulin receptor substrate-1	IRS-1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular scanning for mutations in the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene in Turkish with type_2_diabetes_mellitus .
17020651	0	insulin_receptor_substrate-1	53,81	IRS-1	83,88	insulin receptor substrate-1	IRS-1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The influence of polymorphism the Gly972Arg variant insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene , and G-308A TNF-alpha gene on obesity and insulin resistance in children with obesity -RSB- .
7544300	0	insulin_receptor_substrate-1	22,50	IRS-1	52,57	insulin receptor substrate-1	IRS-1	25467(Tax:10116)	25467(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Effect of glucagon on insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- phosphorylation and association with phosphatidylinositol 3-kinase -LRB- PI 3-kinase -RRB- .
8167159	0	insulin_receptor_substrate-1	21,49	IRS-1	51,56	insulin receptor substrate-1	IRS-1	16367(Tax:10090)	16367(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the mouse insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene and complete sequence of mouse IRS-1 .
8739921	0	insulin_receptor_substrate-1	26,54	IRS-1	56,61	insulin receptor substrate-1	IRS-1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular scanning of the insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- gene in Japanese patients with NIDDM : identification of five novel polymorphisms .
16128672	0	insulin_receptor_substrate-1	28,56	IRS1	22,26	insulin receptor substrate-1	IRS1	3667	3667	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	A novel regulation of IRS1 -LRB- insulin_receptor_substrate-1 -RRB- expression following short term insulin administration .
8477879	0	insulin_receptor_substrate-1	6,34	IRS1	41,45	insulin receptor substrate-1	IRS1	3667	3667	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human insulin_receptor_substrate-1 gene -LRB- IRS1 -RRB- : chromosomal localization to 2q35-q36 .1 and identification of a simple tandem repeat DNA polymorphism .
11063744	0	insulin_receptor_substrate-1	37,65	Protein_kinase_C-zeta	0,21	insulin receptor substrate-1	Protein kinase C-zeta	16367(Tax:10090)	18762(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Protein_kinase_C-zeta phosphorylates insulin_receptor_substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin .
9833943	0	insulin_receptor_substrate-1	188,216	insulin_receptor	114,130	insulin receptor substrate-1	insulin receptor	3667	3643	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Regional difference in insulin inhibition of non-esterified fatty_acid release from human adipocytes : relation to insulin_receptor phosphorylation and intracellular signalling through the insulin_receptor_substrate-1 pathway .
16873706	0	insulin_receptor_substrate-1	70,98	p85alpha	127,135	insulin receptor substrate-1	p85alpha	3667	5295	Gene	Gene	expression|amod|START_ENTITY phosphorylation|nmod|expression phosphorylation|nmod|END_ENTITY	Molecular mechanisms of insulin resistance : serine phosphorylation of insulin_receptor_substrate-1 and increased expression of p85alpha : the two sides of a coin .
8621590	0	insulin_receptor_substrate-1_and_4PS	49,85	c-Crk	27,32	insulin receptor substrate-1 and 4PS	c-Crk	16367(Tax:10090)	12928(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	The proto-oncogene product c-Crk associates with insulin_receptor_substrate-1_and_4PS .
9334184	0	insulin_receptor_substrate-2	55,83	Erythropoietin	0,14	insulin receptor substrate-2	Erythropoietin	8660	2056	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces the tyrosine phosphorylation of insulin_receptor_substrate-2 .
10829031	0	insulin_receptor_substrate-2	18,46	Glut4	73,78	insulin receptor substrate-2	Glut4	384783(Tax:10090)	20528(Tax:10090)	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|nmod|END_ENTITY	Essential role of insulin_receptor_substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes .
8662806	0	insulin_receptor_substrate-2	15,43	IRS-2	45,50	insulin receptor substrate-2	IRS-2	8660	8660	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of insulin_receptor_substrate-2 -LRB- IRS-2 -RRB- with the insulin_and_insulin-like_growth_factor_I receptors .
12488959	0	insulin_receptor_substrate-3	22,50	IRS-3	52,57	insulin receptor substrate-3	IRS-3	442338	442338	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Absence of functional insulin_receptor_substrate-3 -LRB- IRS-3 -RRB- gene in humans .
22635093	0	insulin_receptor_substrate-3	84,112	IRS-3	114,119	insulin receptor substrate-3	IRS-3	442338	442338	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence for a negative association between schizophrenia and a polymorphism in the insulin_receptor_substrate-3 -LRB- IRS-3 -RRB- gene .
21407155	0	insulin_receptor_substrate-4	4,32	IRS-4	34,39	insulin receptor substrate-4	IRS-4	8471	8471	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The insulin_receptor_substrate-4 -LRB- IRS-4 -RRB- gene and schizophrenia : no evidence for a main genetic factor , however one report of a single schizophrenia patient with a mutation .
22167131	0	insulin_receptor_substrate-4	40,68	IRS-4	70,75	insulin receptor substrate-4	IRS-4	8471	8471	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between body mass index and insulin_receptor_substrate-4 -LRB- IRS-4 -RRB- gene polymorphisms in patients with schizophrenia .
7575404	0	insulin_receptor_substrate_1	51,79	Angiotensin_II	0,14	insulin receptor substrate 1	Angiotensin II	25467(Tax:10116)	24179(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Angiotensin_II induces tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with phosphatidylinositol 3-kinase in rat heart .
9139682	0	insulin_receptor_substrate_1	69,97	Angiotensin_II	0,14	insulin receptor substrate 1	Angiotensin II	25467(Tax:10116)	24179(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates tyrosine phosphorylation and activation of insulin_receptor_substrate_1 and protein-tyrosine_phosphatase_1D in vascular smooth muscle cells .
8824290	0	insulin_receptor_substrate_1	47,75	Gastrin	0,7	insulin receptor substrate 1	Gastrin	3667	2520	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
8824290	0	insulin_receptor_substrate_1	47,75	Grb2	101,105	insulin receptor substrate 1	Grb2	3667	2885	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nmod|END_ENTITY	Gastrin stimulates tyrosine phosphorylation of insulin_receptor_substrate_1 and its association with Grb2 and the phosphatidylinositol 3-kinase .
11208867	0	insulin_receptor_substrate_1	196,224	IRS-1	226,231	insulin receptor substrate 1	IRS-1	16367(Tax:10090)	16367(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Signal_transducer_and_activator_of_transcription _ -LRB- STAT -RRB- - induced_STAT_inhibitor_1 -LRB- SSI-1 -RRB- / suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- inhibits insulin signal transduction pathway through modulating insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- phosphorylation .
24451368	0	insulin_receptor_substrate_1	101,129	IRS1	131,135	insulin receptor substrate 1	IRS1	16367(Tax:10090)	16367(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Myostatin induces insulin resistance via Casitas_B-lineage_lymphoma_b -LRB- Cblb -RRB- - mediated degradation of insulin_receptor_substrate_1 -LRB- IRS1 -RRB- protein in response to high calorie diet intake .
7515062	0	insulin_receptor_substrate_1	21,49	PTP2C	78,83	insulin receptor substrate 1	PTP2C	3667	5781	Gene	Gene	Dephosphorylation|nmod|START_ENTITY Dephosphorylation|nmod|END_ENTITY	Dephosphorylation of insulin_receptor_substrate_1 by the tyrosine phosphatase PTP2C .
23720771	0	insulin_receptor_substrate_1	30,58	Par14	0,5	insulin receptor substrate 1	Par14	16367(Tax:10090)	69713(Tax:10090)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Par14 protein associates with insulin_receptor_substrate_1 -LRB- IRS-1 -RRB- , thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions .
15316008	0	insulin_receptor_substrate_1	15,43	SH2-B	0,5	insulin receptor substrate 1	SH2-B	3667	25970	Gene	Gene	activation|amod|START_ENTITY promotes|dobj|activation promotes|nsubj|END_ENTITY	SH2-B promotes insulin_receptor_substrate_1 -LRB- IRS1 -RRB- - and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin .
15318176	0	insulin_receptor_substrate_1	8,36	estrogen_receptor_alpha	52,75	insulin receptor substrate 1	estrogen receptor alpha	3667	2099	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nuclear insulin_receptor_substrate_1 interacts with estrogen_receptor_alpha at ERE promoters .
17591841	0	insulin_receptor_substrate_1	28,56	estrogen_receptor_alpha	4,27	insulin receptor substrate 1	estrogen receptor alpha	3667	2099	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	The estrogen_receptor_alpha : insulin_receptor_substrate_1 complex in breast_cancer : structure-function relationships .
9128728	0	insulin_receptor_substrate_1	40,68	insulin_receptor	76,92	insulin receptor substrate 1	insulin receptor	3667	3643	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	In vitro binding and phosphorylation of insulin_receptor_substrate_1 by the insulin_receptor .
9305869	0	insulin_receptor_substrate_1	37,65	interleukin-4	81,94	insulin receptor substrate 1	interleukin-4	3667	3565	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Janus kinase-dependent activation of insulin_receptor_substrate_1 in response to interleukin-4 , oncostatin_M , and the interferons .
19875459	0	insulin_receptor_substrate_2	9,37	IRS2	39,43	insulin receptor substrate 2	IRS2	8660	8660	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Neuronal insulin_receptor_substrate_2 -LRB- IRS2 -RRB- expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter .
19875459	0	insulin_receptor_substrate_2	9,37	ZBP89	72,77	insulin receptor substrate 2	ZBP89	8660	7707	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Neuronal insulin_receptor_substrate_2 -LRB- IRS2 -RRB- expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter .
21104145	0	insulin_receptor_substrate_4	8,36	IRS4	38,42	insulin receptor substrate 4	IRS4	8471	8471	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Porcine insulin_receptor_substrate_4 -LRB- IRS4 -RRB- gene : cloning , polymorphism and association study .
12052866	0	insulin_receptor_substrate_4	16,44	SOCS-6	0,6	insulin receptor substrate 4	SOCS-6	16370(Tax:10090)	54607(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	SOCS-6 binds to insulin_receptor_substrate_4 , and mice lacking the SOCS-6 gene exhibit mild growth_retardation .
22677019	0	insulinlike_growth_factor-I	53,80	OCN	35,38	insulinlike growth factor-I	OCN	3479	632	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	The dynamic changes of circulating OCN + cells versus insulinlike_growth_factor-I during primary healing of orthognathic surgeries .
21343251	0	insulinoma-associated_2	14,37	Ngn3	114,118	insulinoma-associated 2	Ngn3	56856(Tax:10090)	11925(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of insulinoma-associated_2 -LRB- INSM2 -RRB- in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1 .
11445874	0	int-2	23,28	FGF-3	29,34	int-2	FGF-3	2248	2248	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Detection of amplified int-2 / FGF-3 gene in primary breast_carcinomas using differential polymerase chain reaction .
1425349	0	int-2	40,45	FGF-3	47,52	int-2	FGF-3	373669(Tax:8355)	373669(Tax:8355)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Developmental expression of the Xenopus int-2 -LRB- FGF-3 -RRB- gene : activation by mesodermal and neural induction .
7892260	0	int-2	120,125	Fgf-3	126,131	int-2	Fgf-3	14174(Tax:10090)	14174(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|compound|END_ENTITY	Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2 / Fgf-3 transgenic_mice .
8449602	0	int-2	0,5	c-erbB-2	111,119	int-2	c-erbB-2	2248	2064	Gene	Gene	amplification|amod|START_ENTITY amplification|dep|association association|nmod|survival survival|nmod|amplification amplification|acl|END_ENTITY	int-2 amplification in breast_cancer : association with decreased survival and relationship to amplification of c-erbB-2 and c-myc .
19129174	0	integrin-alpha-M	61,77	ITGAM	79,84	integrin-alpha-M	ITGAM	3684	3684	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of imputation-based association in and around the integrin-alpha-M -LRB- ITGAM -RRB- gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic_lupus_erythematosus -LRB- SLE -RRB- .
12509218	0	integrin-associated_protein	20,47	CD47	14,18	integrin-associated protein	CD47	961	961	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD47 -LRB- integrin-associated_protein -RRB- decreases on red blood cells during storage .
14747477	0	integrin-associated_protein	52,79	CD47	80,84	integrin-associated protein	CD47	961	961	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Alpha-Pal/NRF -1 regulates the promoter of the human integrin-associated_protein / CD47 gene .
10762341	0	integrin-associated_protein	13,40	IAP	42,45	integrin-associated protein	IAP	29364(Tax:10116)	29364(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of integrin-associated_protein -LRB- IAP -RRB- mRNA expression during memory consolidation in rat hippocampus .
8896608	0	integrin-associated_protein	57,84	beta_3	33,39	integrin-associated protein	beta 3	961	1934	Gene	Gene	function|nmod|START_ENTITY function|nsubj|END_ENTITY	Thrombospondin modulates alpha v beta_3 function through integrin-associated_protein .
18723083	0	integrin-binding_sialoprotein	39,68	IBSP	70,74	integrin-binding sialoprotein	IBSP	3381	3381	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Identification and characterization of integrin-binding_sialoprotein -LRB- IBSP -RRB- genes in reptile and amphibian .
21680733	0	integrin-linked_kinase	130,152	Angiopoietin-2	0,14	integrin-linked kinase	Angiopoietin-2	3611	285	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Angiopoietin-2 , an angiogenic regulator , promotes initial_growth_and_survival_of_breast_cancer metastases to the lung through the integrin-linked_kinase -LRB- ILK -RRB- - AKT-B cell lymphoma 2 -LRB- Bcl-2 -RRB- pathway .
21339732	0	integrin-linked_kinase	21,43	Cten	0,4	integrin-linked kinase	Cten	3611	84951	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Cten signals through integrin-linked_kinase -LRB- ILK -RRB- and may promote metastasis in colorectal_cancer .
15053919	0	integrin-linked_kinase	89,111	E-cadherin	14,24	integrin-linked kinase	E-cadherin	3611	999	Gene	Gene	transcriptional|nmod|START_ENTITY transcriptional|nsubj|Regulation Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked_kinase .
20091050	0	integrin-linked_kinase	20,42	E-cadherin	87,97	integrin-linked kinase	E-cadherin	3611	999	Gene	Gene	correlates|amod|START_ENTITY expression|nmod|correlates expression|nmod|expression expression|nmod|snail snail|amod|END_ENTITY	Tumor expression of integrin-linked_kinase -LRB- ILK -RRB- correlates with the expression of the E-cadherin repressor snail : an immunohistochemical study in ductal pancreatic_adenocarcinoma .
21136077	0	integrin-linked_kinase	14,36	E-cadherin	106,116	integrin-linked kinase	E-cadherin	3611	999	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|expression expression|amod|END_ENTITY	Expression of integrin-linked_kinase in lung_squamous_cell_carcinoma and adenocarcinoma : correlation with E-cadherin expression , tumor microvessel density and clinical outcome .
19118217	0	integrin-linked_kinase	21,43	EphA1	0,5	integrin-linked kinase	EphA1	3611	2041	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	EphA1 interacts with integrin-linked_kinase and regulates cell morphology and motility .
10716737	0	integrin-linked_kinase	14,36	ILK	38,41	integrin-linked kinase	ILK	3611	3611	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of integrin-linked_kinase -LRB- ILK -RRB- suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate_cancer cells .
12884912	0	integrin-linked_kinase	12,34	ILK	36,39	integrin-linked kinase	ILK	3611	3611	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of integrin-linked_kinase -LRB- ILK -RRB- in cancer progression .
15970428	0	integrin-linked_kinase	32,54	ILK	56,59	integrin-linked kinase	ILK	16202(Tax:10090)	16202(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Differential involvement of the integrin-linked_kinase -LRB- ILK -RRB- in RhoA-dependent rearrangement of F-actin fibers and induction of connective_tissue_growth_factor -LRB- CTGF -RRB- .
16643659	0	integrin-linked_kinase	14,36	ILK	38,41	integrin-linked kinase	ILK	3611	3611	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of integrin-linked_kinase -LRB- ILK -RRB- expression in human oesophageal_squamous_cell_carcinoma cell lines by the EGF and TGFbeta1 growth factors .
23108908	0	integrin-linked_kinase	18,40	ILK	42,45	integrin-linked kinase	ILK	3611	3611	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of integrin-linked_kinase -LRB- ILK -RRB- is associated with tumor progression and an unfavorable prognosis in patients with colorectal_cancer .
24045896	0	integrin-linked_kinase	18,40	ILK	42,45	integrin-linked kinase	ILK	3611	3611	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of integrin-linked_kinase -LRB- ILK -RRB- promotes glioma cell invasion and migration and down-regulates E-cadherin via the NF-kB pathway .
24360977	0	integrin-linked_kinase	18,40	ILK	42,45	integrin-linked kinase	ILK	3611	3611	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of integrin-linked_kinase -LRB- ILK -RRB- promotes migration and invasion of colorectal_cancer cells by inducing epithelial-mesenchymal transition via NF-kB signaling .
19334037	0	integrin-linked_kinase	33,55	Integrin_alphavbeta3	0,20	integrin-linked kinase	Integrin alphavbeta3	3611	3685	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Integrin_alphavbeta3 upregulates integrin-linked_kinase expression in human ovarian_cancer cells via enhancement of ILK gene transcription .
10022929	0	integrin-linked_kinase	51,73	PINCH	21,26	integrin-linked kinase	PINCH	3611	3987	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The LIM-only protein PINCH directly interacts with integrin-linked_kinase and is recruited to integrin-rich sites in spreading cells .
11078733	0	integrin-linked_kinase	116,138	PINCH	49,54	integrin-linked kinase	PINCH	3611	3987	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked_kinase ankyrin repeat domain .
19117955	0	integrin-linked_kinase	77,99	PINCH	68,73	integrin-linked kinase	PINCH	3611	3987	Gene	Gene	adaptor|nmod|START_ENTITY adaptor|dobj|END_ENTITY	Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked_kinase .
17989364	0	integrin-linked_kinase	106,128	SMOC-2	25,31	integrin-linked kinase	SMOC-2	16202(Tax:10090)	64074(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin_D1 expression and DNA synthesis via integrin-linked_kinase .
22638656	0	integrin-linked_kinase	19,41	Snail	81,86	integrin-linked kinase	Snail	3611	6615	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|expression expression|nmod|END_ENTITY	Over-expression of integrin-linked_kinase correlates with aberrant expression of Snail , E-cadherin and N-cadherin in oral_squamous_cell_carcinoma : implications in tumor progression and metastasis .
23107296	0	integrin-linked_kinase	12,34	b-catenin	35,44	integrin-linked kinase	b-catenin	3611	1499	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|amod|END_ENTITY	The role of integrin-linked_kinase / b-catenin pathway in the enhanced MG63 differentiation by micro/nano-textured topography .
10915780	0	integrin-linked_kinase	4,26	cyclin_D1	41,50	integrin-linked kinase	cyclin D1	3611	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|gene gene|amod|END_ENTITY	The integrin-linked_kinase regulates the cyclin_D1 gene through glycogen_synthase_kinase_3beta and cAMP-responsive_element-binding_protein-dependent pathways .
17989364	0	integrin-linked_kinase	106,128	cyclin_D1	63,72	integrin-linked kinase	cyclin D1	16202(Tax:10090)	12443(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin_D1 expression and DNA synthesis via integrin-linked_kinase .
26041412	0	integrin-linked_kinase	120,142	mammalian_target_of_rapamycin	4,33	integrin-linked kinase	mammalian target of rapamycin	3611	2475	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	The mammalian_target_of_rapamycin signaling pathway regulates myocyte enhancer factor-2C phosphorylation levels through integrin-linked_kinase in goat skeletal muscle satellite cells .
12392762	0	integrin_alpha11	22,38	ITGA11	45,51	integrin alpha11	ITGA11	22801	22801	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the human integrin_alpha11 gene -LRB- ITGA11 -RRB- and its promoter .
10065872	0	integrin_alpha3	66,81	CD9	0,3	integrin alpha3	CD9	3675	928	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CD9 is expressed in extravillous trophoblasts in association with integrin_alpha3 and integrin_alpha5 .
19748482	0	integrin_alpha4	61,76	DcR3	0,4	integrin alpha4	DcR3	3676	8771	Gene	Gene	apoptosis|nmod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	DcR3 protects THP-1 macrophages from apoptosis by increasing integrin_alpha4 .
20332114	0	integrin_alpha5	15,30	ErbB2	0,5	integrin alpha5	ErbB2	3678	2064	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	ErbB2 requires integrin_alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells .
10403775	0	integrin_alpha7	112,127	ITGA7	134,139	integrin alpha7	ITGA7	3679	3679	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure , genetic localization , and identification of the cardiac and skeletal muscle transcripts of the human integrin_alpha7 gene -LRB- ITGA7 -RRB- .
11244970	0	integrin_alpha_5	15,31	beta_1	33,39	integrin alpha 5	beta 1	3678	3779	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	-LSB- Expression of integrin_alpha_5 , beta_1 subunit and fibronectin mRNAs in human hepatocellular_carcinoma -RSB- .
8864745	0	integrin_alpha_6	24,40	integrin_alpha_6	66,82	integrin alpha 6	integrin alpha 6	3655	3655	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Granulosa cells express integrin_alpha_6 : possible involvement of integrin_alpha_6 in folliculogenesis .
8864745	0	integrin_alpha_6	66,82	integrin_alpha_6	24,40	integrin alpha 6	integrin alpha 6	3655	3655	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Granulosa cells express integrin_alpha_6 : possible involvement of integrin_alpha_6 in folliculogenesis .
24130503	0	integrin_alpha_L	29,45	Itgal	47,52	integrin alpha L	Itgal	16408(Tax:10090)	16408(Tax:10090)	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Natural genetic variation of integrin_alpha_L -LRB- Itgal -RRB- modulates ischemic_brain_injury in stroke .
17879163	0	integrin_alpha_v	100,116	FAK	147,150	integrin alpha v	FAK	3685	5747	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	An altered fibronectin matrix induces anoikis of human squamous_cell_carcinoma cells by suppressing integrin_alpha_v levels and phosphorylation of FAK and ERK .
12356872	0	integrin_alpha_v_beta_5	38,61	P21-activated_kinase_4	0,22	integrin alpha v beta 5	P21-activated kinase 4	3693	10298	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	P21-activated_kinase_4 interacts with integrin_alpha_v_beta_5 and regulates alpha v beta 5-mediated cell migration .
19571258	0	integrin_alpha_v_beta_6	55,78	Secreted_phosphoprotein_1	0,25	integrin alpha v beta 6	Secreted phosphoprotein 1	311061(Tax:10116)	25353(Tax:10116)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Secreted_phosphoprotein_1 -LRB- SPP1 , osteopontin -RRB- binds to integrin_alpha_v_beta_6 on porcine trophectoderm cells and integrin_alpha_v_beta_3 on uterine luminal epithelial cells , and promotes trophectoderm cell adhesion and migration .
15308622	0	integrin_alphavbeta3	26,46	CCN1	63,67	integrin alphavbeta3	CCN1	3685	3491	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Identification of a novel integrin_alphavbeta3 binding site in CCN1 -LRB- CYR61 -RRB- critical for pro-angiogenic activities in vascular endothelial cells .
12874388	0	integrin_alphavbeta3	10,30	MMP-9	65,70	integrin alphavbeta3	MMP-9	3685	4318	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Activated integrin_alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast_cancer cells .
19487690	0	integrin_alphavbeta3	44,64	Plasminogen_activator_inhibitor-1	0,33	integrin alphavbeta3	Plasminogen activator inhibitor-1	3685	5054	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Plasminogen_activator_inhibitor-1 regulates integrin_alphavbeta3 expression and autocrine transforming_growth_factor_beta signaling .
23789592	0	integrin_b1	53,64	Itgb1	66,71	integrin b1	Itgb1	16412(Tax:10090)	16412(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The use of alternative polyadenylation sites renders integrin_b1 -LRB- Itgb1 -RRB- mRNA isoforms with differential stability during mammary gland development .
23803695	0	integrin_b4	96,107	Metallopanstimulin-1	0,20	integrin b4	Metallopanstimulin-1	3691	6232	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Metallopanstimulin-1 regulates invasion and migration of gastric_cancer cells partially through integrin_b4 .
26095157	0	integrin_beta-1	65,80	Fibulin-5	0,9	integrin beta-1	Fibulin-5	3688	10516	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Fibulin-5 regulates keloid-derived fibroblast-like cells through integrin_beta-1 .
23402326	0	integrin_beta1	15,29	EGFR	53,57	integrin beta1	EGFR	3688	1956	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|resistance resistance|compound|END_ENTITY	Association of integrin_beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small_cell_lung_cancer .
16293568	0	integrin_beta3	38,52	Angiotensin_II	0,14	integrin beta3	Angiotensin II	3690	183	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates endothelial integrin_beta3 expression via nuclear_factor-kappaB activation .
19656390	0	integrin_beta3	132,146	Gonadotropin-releasing_hormone	0,30	integrin beta3	Gonadotropin-releasing hormone	3690	2796	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|dep|involvement	Gonadotropin-releasing_hormone -LRB- GnRH -RRB- - I and GnRH-II induce cell growth inhibition in human endometrial_cancer cells : involvement of integrin_beta3 and focal_adhesion_kinase .
17292354	0	integrin_beta3	42,56	MacMARCKS	18,27	integrin beta3	MacMARCKS	3690	65108	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	The regulation of MacMARCKS expression by integrin_beta3 .
16293568	0	integrin_beta3	38,52	nuclear_factor-kappaB	68,89	integrin beta3	nuclear factor-kappaB	3690	4790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Angiotensin_II stimulates endothelial integrin_beta3 expression via nuclear_factor-kappaB activation .
15009117	0	integrin_beta4	99,113	ITGB4	120,125	integrin beta4	ITGB4	3691	3691	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pyloric_atresia-junctional_epidermolysis_bullosa_syndrome showing novel 594insC/Q425P mutations in integrin_beta4 gene -LRB- ITGB4 -RRB- .
9892956	0	integrin_beta4	76,90	ITGB4	97,102	integrin beta4	ITGB4	3691	3691	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pyloric_atresia-junctional_epidermolysis_bullosa_syndrome : mutations in the integrin_beta4 gene -LRB- ITGB4 -RRB- in two unrelated patients with mild disease .
19544212	0	integrin_beta_2	44,59	ITGB2	61,66	integrin beta 2	ITGB2	102400120	102400120	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of novel allelic variants of integrin_beta_2 -LRB- ITGB2 -RRB- gene and screening for Bubaline leukocyte_adhesion_deficiency syndrome in Indian water buffaloes -LRB- Bubalus_bubalis -RRB- .
12733346	0	integrin_beta_3	67,82	transforming_growth_factor_beta_1	12,45	integrin beta 3	transforming growth factor beta 1	3690	7040	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	-LSB- Effects of transforming_growth_factor_beta_1 on the expression of integrin_beta_3 and the activity of focal_adhesion_kinase on human vascular endothelial cell -RSB- .
9194858	0	integrin_beta_4	28,43	ITGB4	50,55	integrin beta 4	ITGB4	3691	3691	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the integrin_beta_4 gene -LRB- ITGB4 -RRB- : a homozygous splice-site mutation in a patient with junctional_epidermolysis_bullosa associated with pyloric_atresia .
15225631	0	integrin_beta_7	34,49	filamin_A	15,24	integrin beta 7	filamin A	3695	2316	Gene	Gene	domain|amod|START_ENTITY END_ENTITY|nmod|domain	Interaction of filamin_A with the integrin_beta_7 cytoplasmic domain : role of alternative splicing and phosphorylation .
8103515	0	integrin_gene_promoter	53,75	CD11a	24,29	integrin gene promoter	CD11a	3683	3683	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the CD11a -LRB- alpha L , LFA-1_alpha -RRB- integrin_gene_promoter .
15579315	0	integrin_subunit_alpha8	57,80	ITGA8	87,92	integrin subunit alpha8	ITGA8	8516	8516	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and sequence variation of the human integrin_subunit_alpha8 gene -LRB- ITGA8 -RRB- .
12147176	0	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	20,84	IHRP	86,90	inter-alpha-trypsin inhibitor family heavy chain-related protein	IHRP	3700	3700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SNP analysis of the inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene by a fluorescence-adapted SSCP method .
8797089	0	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	44,108	IHRP	110,114	inter-alpha-trypsin inhibitor family heavy chain-related protein	IHRP	3700	3700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene -LRB- ITIHL1 -RRB- .
7587397	0	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	17,81	ITIHL1	88,94	inter-alpha-trypsin inhibitor family heavy chain-related protein	ITIHL1	3700	3700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein gene -LRB- ITIHL1 -RRB- to human chromosome 3p21 -- > p14 .
8797089	0	inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein	44,108	ITIHL1	122,128	inter-alpha-trypsin inhibitor family heavy chain-related protein	ITIHL1	3700	3700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the human inter-alpha-trypsin_inhibitor_family_heavy_chain-related_protein -LRB- IHRP -RRB- gene -LRB- ITIHL1 -RRB- .
8889810	0	inter-alpha-trypsin_inhibitor_light_chain	14,55	bikunin	57,64	inter-alpha-trypsin inhibitor light chain	bikunin	259	259	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of inter-alpha-trypsin_inhibitor_light_chain -LRB- bikunin -RRB- in human pancreas .
11099110	0	intercellular_adhesio_nmolecule-1	14,47	ICAM-1	49,55	intercellular adhesio nmolecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of intercellular_adhesio_nmolecule-1 -LRB- ICAM-1 -RRB- expression in ultraviolet B-irradiated human antigen-presenting_cells is restored after repair of cyclobutane_pyrimidine_dimers .
10076954	0	intercellular_adhesion_molecule	51,82	ICAM-1	84,90	intercellular adhesion molecule	ICAM-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hemorrhagic_shock results in intestinal muscularis intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- expression , neutrophil infiltration , and smooth muscle_dysfunction .
12545819	0	intercellular_adhesion_molecule	29,60	ICAM-1	62,68	intercellular adhesion molecule	ICAM-1	3383	3383	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	-LSB- Transcription regulation of intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- on lymphatic endothelial cells of rectum adenocarcinoma of human -RSB- .
2469503	0	intercellular_adhesion_molecule	36,67	ICAM-1	69,75	intercellular adhesion molecule	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of expression of a human intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- during lymphohematopoietic differentiation .
8838428	0	intercellular_adhesion_molecule	36,67	ICAM-1	69,75	intercellular adhesion molecule	ICAM-1	3383	3383	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of the intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- on the cell surface of high endothelial venules in lymph nodes .
9990314	0	intercellular_adhesion_molecule	73,104	ICAM-1	106,112	intercellular adhesion molecule	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two gamma-interferon-activation sites -LRB- GAS -RRB- on the promoter of the human intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- gene are required for induction of transcription by IFN-gamma .
16166569	0	intercellular_adhesion_molecule-1	29,62	12/15-lipoxygenase	0,18	intercellular adhesion molecule-1	12/15-lipoxygenase	15894(Tax:10090)	11687(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	12/15-lipoxygenase regulates intercellular_adhesion_molecule-1 expression and monocyte adhesion to endothelium through activation of RhoA and nuclear_factor-kappaB .
24667577	0	intercellular_adhesion_molecule-1	21,54	Adiponectin	0,11	intercellular adhesion molecule-1	Adiponectin	3383	9370	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Adiponectin enhances intercellular_adhesion_molecule-1 expression and promotes monocyte adhesion in human synovial fibroblasts .
26503469	0	intercellular_adhesion_molecule-1	22,55	Amphiregulin	0,12	intercellular adhesion molecule-1	Amphiregulin	3383	374	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Amphiregulin enhances intercellular_adhesion_molecule-1 expression and promotes tumor metastasis in human osteosarcoma .
10517737	0	intercellular_adhesion_molecule-1	26,59	Angiotensin_II	0,14	intercellular adhesion molecule-1	Angiotensin II	3383	183	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo .
16343550	0	intercellular_adhesion_molecule-1	26,59	Angiotensin_II	0,14	intercellular adhesion molecule-1	Angiotensin II	3383	183	Gene	Gene	pathway|amod|START_ENTITY stimulates|dobj|pathway stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates intercellular_adhesion_molecule-1 via an AT1 receptor/nuclear factor-kappaB pathway in brain microvascular endothelial cells .
14691297	0	intercellular_adhesion_molecule-1	13,46	CD4	104,107	intercellular adhesion molecule-1	CD4	3383	920	Gene	Gene	cells|amod|START_ENTITY Induction|nmod|cells Induction|dep|role role|nmod|coreceptors coreceptors|compound|END_ENTITY	Induction of intercellular_adhesion_molecule-1 on human brain endothelial cells by HIV-1 gp120 : role of CD4 and chemokine coreceptors .
16895560	0	intercellular_adhesion_molecule-1	49,82	CD4	29,32	intercellular adhesion molecule-1	CD4	3383	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Costimulation of naive human CD4 T cells through intercellular_adhesion_molecule-1 promotes differentiation to a memory phenotype that is not strictly the result of multiple rounds of cell division .
22804504	0	intercellular_adhesion_molecule-1	120,153	CD4	73,76	intercellular adhesion molecule-1	CD4	3383	920	Gene	Gene	regulating|nmod|START_ENTITY motility|advcl|regulating motility|nsubj|T-cell T-cell|compound|END_ENTITY	Wiskott-Aldrich_syndrome protein controls antigen-presenting cell-driven CD4 + T-cell motility by regulating adhesion to intercellular_adhesion_molecule-1 .
7689606	0	intercellular_adhesion_molecule-1	36,69	CD4	161,164	intercellular adhesion molecule-1	CD4	3383	920	Gene	Gene	ligands|amod|START_ENTITY Costimulation|nmod|ligands augments|nsubj|Costimulation augments|dobj|death death|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Costimulation with integrin ligands intercellular_adhesion_molecule-1 or vascular_cell_adhesion_molecule-1 augments activation-induced death of antigen-specific CD4 + T lymphocytes .
16671908	0	intercellular_adhesion_molecule-1	89,122	CD40	124,128	intercellular adhesion molecule-1	CD40	3383	958	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibitory effects of Triptolide on interferon-gamma-induced human leucocyte antigen-DR , intercellular_adhesion_molecule-1 , CD40 expression on retro-ocular fibroblasts derived from patients with Graves ' _ ophthalmopathy .
21895545	0	intercellular_adhesion_molecule-1	32,65	CD44	26,30	intercellular adhesion molecule-1	CD44	3383	960	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Prognostic value of serum CD44 , intercellular_adhesion_molecule-1 and vascular_cell_adhesion_molecule-1 levels in patients with indolent non-Hodgkin_lymphomas .
15753842	0	intercellular_adhesion_molecule-1	17,50	CD54	11,15	intercellular adhesion molecule-1	CD54	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for CD54 -LRB- intercellular_adhesion_molecule-1 -RRB- in leukocyte recruitment to the lung during the development of experimental idiopathic_pneumonia_syndrome .
1671649	0	intercellular_adhesion_molecule-1	14,47	CD54	49,53	intercellular adhesion molecule-1	CD54	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- CD54 -RRB- on hematopoietic progenitors .
19187601	0	intercellular_adhesion_molecule-1	24,57	Cardiotrophin-1	0,15	intercellular adhesion molecule-1	Cardiotrophin-1	3383	1489	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Cardiotrophin-1 induces intercellular_adhesion_molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells .
9434632	0	intercellular_adhesion_molecule-1	28,61	E-selectin	8,18	intercellular adhesion molecule-1	E-selectin	3383	6401	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Soluble E-selectin enhances intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human tumor cell lines .
10030601	0	intercellular_adhesion_molecule-1	21,54	ICAM-1	56,62	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	In vitro and in situ intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by endothelial cells lining a polyester fabric .
10435852	0	intercellular_adhesion_molecule-1	30,63	ICAM-1	65,71	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Longitudinal study of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in sera of patients with Graves ' _ disease .
10490211	0	intercellular_adhesion_molecule-1	22,55	ICAM-1	57,63	intercellular adhesion molecule-1	ICAM-1	281839(Tax:9913)	281839(Tax:9913)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	In situ expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- mRNA in calves with acute Pasteurella_haemolytica pneumonia .
10517737	0	intercellular_adhesion_molecule-1	26,59	ICAM-1	61,67	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II stimulates intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo .
10692259	0	intercellular_adhesion_molecule-1	23,56	ICAM-1	58,64	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in amnion with term and preterm_labour .
10752199	0	intercellular_adhesion_molecule-1	9,42	ICAM-1	44,50	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	-LSB- Soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- levels in HIV infected children -RSB- .
10773353	0	intercellular_adhesion_molecule-1	53,86	ICAM-1	88,94	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between type 1 diabetes age-at-onset and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphism .
10971511	0	intercellular_adhesion_molecule-1	51,84	ICAM-1	86,92	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Triamcinolone_acetonide modulates permeability and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression of the ECV304 cell line : implications for macular_degeneration .
11122238	0	intercellular_adhesion_molecule-1	126,159	ICAM-1	161,167	intercellular adhesion molecule-1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Roles of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , transforming growth factor-beta -LRB- TGF-beta -RRB- , and IL-10 in the modulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by macrophages during mycobacterial_infection .
11151765	0	intercellular_adhesion_molecule-1	21,54	ICAM-1	56,62	intercellular adhesion molecule-1	ICAM-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	High glucose-induced intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent .
12185712	0	intercellular_adhesion_molecule-1	15,48	ICAM-1	50,56	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on the surface of peripheral blood lymphocytes of pregnant women with pregnancy-induced hypertension -RSB- .
12551926	0	intercellular_adhesion_molecule-1	75,108	ICAM-1	110,116	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Human rhinovirus selectively modulates membranous and soluble forms of its intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- receptor to promote epithelial cell infectivity .
1281230	0	intercellular_adhesion_molecule-1	60,93	ICAM-1	95,101	intercellular adhesion molecule-1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Endothelial_cell_leukocyte_adhesion_molecule-1 -LRB- ELAM-1 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in gingival tissue during health and experimentally-induced gingivitis .
1349161	0	intercellular_adhesion_molecule-1	18,51	ICAM-1	53,59	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in human renal allografts and cultured human tubular cells .
1352310	0	intercellular_adhesion_molecule-1	16,49	ICAM-1	51,57	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide .
1352747	0	intercellular_adhesion_molecule-1	12,45	ICAM-1	47,53	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Circulating intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- antigen in sera of patients with idiopathic_pulmonary_fibrosis .
1355095	0	intercellular_adhesion_molecule-1	15,48	ICAM-1	50,56	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- with actin-containing cytoskeleton and alpha-actinin .
1356028	0	intercellular_adhesion_molecule-1	22,55	ICAM-1	57,63	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Possible induction of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on endothelial cells by platelet-activating_factor -LRB- PAF -RRB- .
1373746	0	intercellular_adhesion_molecule-1	85,118	ICAM-1	120,126	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The state of differentiation of cultured human keratinocytes determines the level of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression induced by gamma interferon .
15142692	0	intercellular_adhesion_molecule-1	37,70	ICAM-1	72,78	intercellular adhesion molecule-1	ICAM-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Thrombosis and altered expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- after avulsion_injury in rat vessels .
15866119	0	intercellular_adhesion_molecule-1	39,72	ICAM-1	74,80	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of endometriosis and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphisms in a Japanese population .
1673709	0	intercellular_adhesion_molecule-1	31,64	ICAM-1	66,72	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cytokine-induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in cultured human oligodendrocytes and astrocytes .
1676215	0	intercellular_adhesion_molecule-1	14,47	ICAM-1	49,55	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in benign naevi and malignant_melanomas .
1680698	0	intercellular_adhesion_molecule-1	43,76	ICAM-1	78,84	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression , function and regulation of the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on human intestinal epithelial cell lines .
1682392	0	intercellular_adhesion_molecule-1	14,47	ICAM-1	49,55	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the skin of patients with systemic_scleroderma .
16938116	0	intercellular_adhesion_molecule-1	63,96	ICAM-1	98,104	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Synergistic effect of interleukin-6 promoter -LRB- IL6 -634 C/G -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 469K/E -RRB- gene polymorphisms on the risk of endometriosis in Japanese women .
19074768	0	intercellular_adhesion_molecule-1	137,170	ICAM-1	172,178	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Protein_kinase_C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian_target_of_rapamycin to modulate NF-kappaB activation and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in endothelial cells .
1973679	0	intercellular_adhesion_molecule-1	22,55	ICAM-1	57,63	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Hepatic expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in viral hepatitis_B .
1974176	0	intercellular_adhesion_molecule-1	23,56	ICAM-1	58,64	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cytokine regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on human glioblastoma cells .
1977768	0	intercellular_adhesion_molecule-1	35,68	ICAM-1	70,76	intercellular adhesion molecule-1	ICAM-1	100717967	100717967	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Endothelial cell expression of the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the central nervous system of guinea_pigs during acute and chronic relapsing experimental_allergic_encephalomyelitis .
20665551	0	intercellular_adhesion_molecule-1	89,122	ICAM-1	124,130	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-17 synergizes with IFNy or TNFa to promote inflammatory mediator release and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human intervertebral disc cells .
22609477	0	intercellular_adhesion_molecule-1	4,37	ICAM-1	39,45	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	The intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene polymorphism K469E in end-stage_renal_disease patients with cardiovascular_disease .
25026345	0	intercellular_adhesion_molecule-1	86,119	ICAM-1	121,127	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
2654218	0	intercellular_adhesion_molecule-1	33,66	ICAM-1	68,74	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Kinetics and characterization of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on keratinocytes in various inflammatory skin_lesions and malignant cutaneous_lymphomas .
3257922	0	intercellular_adhesion_molecule-1	22,55	ICAM-1	57,63	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	The function of human intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the generation of an immune response .
7507012	0	intercellular_adhesion_molecule-1	30,63	ICAM-1	65,71	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MHC class I , MHC class II and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in inflammatory_myopathies .
7705360	0	intercellular_adhesion_molecule-1	33,66	ICAM-1	68,74	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive expression of human intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is regulated by differentially active enhancing and silencing elements .
7798616	0	intercellular_adhesion_molecule-1	38,71	ICAM-1	73,79	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Suppressive effect of antioxidants on intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human epidermal keratinocytes .
7880394	0	intercellular_adhesion_molecule-1	14,47	ICAM-1	49,55	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on cultured human endometrial stromal cells and its role in the interaction with natural killers .
7901895	0	intercellular_adhesion_molecule-1	8,41	ICAM-1	43,49	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- antigen in patients with rheumatoid_arthritis .
7909596	0	intercellular_adhesion_molecule-1	14,47	ICAM-1	49,55	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by reactive mesothelial cells in pleural_effusions .
7930472	0	intercellular_adhesion_molecule-1	58,91	ICAM-1	93,99	intercellular adhesion molecule-1	ICAM-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Cultured rat hepatic sinusoidal endothelial cells express intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by tumor_necrosis_factor-alpha or interleukin-1_alpha stimulation .
7974918	0	intercellular_adhesion_molecule-1	15,48	ICAM-1	50,56	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Stimulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- antigen expression and shedding by interferon-gamma and phorbol_ester in human renal_carcinoma cell cultures : relation to peripheral blood mononuclear cell adhesion .
8104198	0	intercellular_adhesion_molecule-1	14,47	ICAM-1	49,55	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in ischemic and reperfused canine myocardium .
8105425	0	intercellular_adhesion_molecule-1	32,65	ICAM-1	67,73	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum and CSF levels of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in inflammatory neurologic_diseases .
9057191	0	intercellular_adhesion_molecule-1	18,51	ICAM-1	53,59	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in pancreatic_adenocarcinoma in comparison with normal pancreas .
9158091	0	intercellular_adhesion_molecule-1	56,89	ICAM-1	91,97	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of the endothelial cell adhesion molecule intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by autoantibodies in autoimmune_vasculitis .
9215589	0	intercellular_adhesion_molecule-1	14,47	ICAM-1	49,55	intercellular adhesion molecule-1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on vascular endothelial cells and renal tubular cells in the generalized Shwartzman reaction as an experimental disseminated intravascular_coagulation model .
9269313	0	intercellular_adhesion_molecule-1	37,70	ICAM-1	72,78	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Late and persistent up-regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression by ionizing radiation in human endothelial cells in vitro .
9353323	0	intercellular_adhesion_molecule-1	50,83	ICAM-1	85,91	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Targeted inhibition of interferon-gamma-dependent intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression using dominant-negative Stat1 .
9400721	0	intercellular_adhesion_molecule-1	16,49	ICAM-1	51,57	intercellular adhesion molecule-1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the lungs of silica-exposed mice .
9434632	0	intercellular_adhesion_molecule-1	28,61	ICAM-1	63,69	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Soluble E-selectin enhances intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in human tumor cell lines .
9451527	0	intercellular_adhesion_molecule-1	31,64	ICAM-1	66,72	intercellular adhesion molecule-1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of hyperbaric oxygen on intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression in murine lung .
9763331	0	intercellular_adhesion_molecule-1	23,56	ICAM-1	58,64	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	High levels of soluble intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in crevicular fluid of periodontitis patients with plaque .
9852101	0	intercellular_adhesion_molecule-1	62,95	ICAM-1	97,103	intercellular adhesion molecule-1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lactosylceramide mediates tumor_necrosis_factor-alpha-induced intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression and the adhesion of neutrophil in human umbilical vein endothelial cells .
9875636	0	intercellular_adhesion_molecule-1	29,62	ICAM-1	64,70	intercellular adhesion molecule-1	ICAM-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in organotypic cultures of rat liver tissue .
24535541	0	intercellular_adhesion_molecule-1	45,78	ICAM1	80,85	intercellular adhesion molecule-1	ICAM1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic prediction and diagnostic role of intercellular_adhesion_molecule-1 -LRB- ICAM1 -RRB- expression in clear_cell_renal_cell_carcinoma .
25145994	0	intercellular_adhesion_molecule-1	38,71	ICAM1	73,78	intercellular adhesion molecule-1	ICAM1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Associations of a polymorphism in the intercellular_adhesion_molecule-1 -LRB- ICAM1 -RRB- gene and ICAM1 serum levels with migraine in a Chinese Han population .
10902810	0	intercellular_adhesion_molecule-1	35,68	Insulin	0,7	intercellular adhesion molecule-1	Insulin	3383	3630	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Insulin inhibits the expression of intercellular_adhesion_molecule-1 by human_aortic_endothelial_cells through stimulation of nitric_oxide .
21816944	0	intercellular_adhesion_molecule-1	93,126	Interleukin-1_alpha	0,19	intercellular adhesion molecule-1	Interleukin-1 alpha	3383	3552	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_alpha produced by human T-cell_leukaemia_virus_type_I-infected T cells induces intercellular_adhesion_molecule-1 expression on lung epithelial cells .
7819742	0	intercellular_adhesion_molecule-1	26,59	Interleukin-5	0,13	intercellular adhesion molecule-1	Interleukin-5	3383	3567	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-5 upregulates intercellular_adhesion_molecule-1 gene expression in the nasal mucosa in nasal_allergy but not in nonallergic rhinitis .
15749873	0	intercellular_adhesion_molecule-1	12,45	LFA-1	46,51	intercellular adhesion molecule-1	LFA-1	3383	3683	Gene	Gene	role|nmod|START_ENTITY role|dep|interactions interactions|compound|END_ENTITY	The role of intercellular_adhesion_molecule-1 / LFA-1 interactions in the generation of tumor-specific CD8 + T cell responses .
3134364	0	intercellular_adhesion_molecule-1	66,99	LFA-1	42,47	intercellular adhesion molecule-1	LFA-1	3383	3683	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- interaction with intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells .
7479308	0	intercellular_adhesion_molecule-1	38,71	Substance_P	0,11	intercellular adhesion molecule-1	Substance P	3383	6863	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Substance_P induces the expression of intercellular_adhesion_molecule-1 on vascular endothelial cells and enhances neutrophil transendothelial migration .
17543554	0	intercellular_adhesion_molecule-1	108,141	Syk	23,26	intercellular adhesion molecule-1	Syk	15894(Tax:10090)	20963(Tax:10090)	Gene	Gene	necessary|advcl|START_ENTITY necessary|nsubj|END_ENTITY	Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha -LRB- L -RRB- beta -LRB- 2 -RRB- integrin-mediated rolling on intercellular_adhesion_molecule-1 .
12420742	0	intercellular_adhesion_molecule-1	57,90	TNF-alpha	102,111	intercellular adhesion molecule-1	TNF-alpha	3383	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Monochloramine inhibits the expression of E-selectin and intercellular_adhesion_molecule-1 induced by TNF-alpha through the suppression of NF-kappaB activation in human endothelial cells .
17607964	0	intercellular_adhesion_molecule-1	42,75	TNF-alpha	258,267	intercellular adhesion molecule-1	TNF-alpha	3383	7124	Gene	Gene	-LSB-|nmod|START_ENTITY induced|csubj|-LSB- induced|nmod|-RSB- -RSB-|appos|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
8973625	0	intercellular_adhesion_molecule-1	69,102	TNF-alpha	190,199	intercellular adhesion molecule-1	TNF-alpha	3383	7124	Gene	Gene	factor-alpha|amod|START_ENTITY factor-alpha|appos|END_ENTITY	Expression of leucocyte-endothelial adhesion molecules is limited to intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- in the lung of pneumoconiotic patients : role of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- .
1282723	0	intercellular_adhesion_molecule-1	58,91	Tumor_necrosis_factor-alpha	0,27	intercellular adhesion molecule-1	Tumor necrosis factor-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha - and interleukin-1-stimulated intercellular_adhesion_molecule-1 expression by murine renal tubular epithelial cells is transcriptionally regulated and involves protein kinase C .
23803661	0	intercellular_adhesion_molecule-1	15,48	bradykinin	66,76	intercellular adhesion molecule-1	bradykinin	3383	3827	Gene	Gene	up-regulation|amod|START_ENTITY up-regulation|nmod|END_ENTITY	Involvement of intercellular_adhesion_molecule-1 up-regulation in bradykinin promotes cell motility in human prostate_cancers .
23285691	0	intercellular_adhesion_molecule-1	31,64	e-cadherin	77,87	intercellular adhesion molecule-1	e-cadherin	3383	999	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Impact of celecoxib on soluble intercellular_adhesion_molecule-1 and soluble e-cadherin concentrations in human colon_cancer cell line cultures exposed to phytic_acid and TNF-alpha .
12007734	0	intercellular_adhesion_molecule-1	16,49	fibrinogen	55,65	intercellular adhesion molecule-1	fibrinogen	3383	2244	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of intercellular_adhesion_molecule-1 with fibrinogen .
15736117	0	intercellular_adhesion_molecule-1	30,63	fibrinogen	95,105	intercellular adhesion molecule-1	fibrinogen	3383	2244	Gene	Gene	gene|amod|START_ENTITY polymorphism|nmod|gene associated|nsubjpass|polymorphism associated|nmod|level level|compound|END_ENTITY	The K469E polymorphism of the intercellular_adhesion_molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes .
19332210	0	intercellular_adhesion_molecule-1	87,120	fibrinogen	148,158	intercellular adhesion molecule-1	fibrinogen	3383	2244	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Candidate genetic variants in the fibrinogen , methylenetetrahydrofolate_reductase , and intercellular_adhesion_molecule-1 genes and plasma levels of fibrinogen , homocysteine , and intercellular_adhesion_molecule-1 among various race/ethnic groups : data from the Women 's Genome Health Study .
7822297	0	intercellular_adhesion_molecule-1	79,112	fibrinogen	34,44	intercellular adhesion molecule-1	fibrinogen	3383	2244	Gene	Gene	interaction|amod|START_ENTITY recognition|nmod|interaction recognition|nmod|sequence sequence|compound|END_ENTITY	Structural recognition of a novel fibrinogen gamma chain sequence -LRB- 117-133 -RRB- by intercellular_adhesion_molecule-1 mediates leukocyte-endothelium interaction .
9182580	0	intercellular_adhesion_molecule-1	51,84	fibrinogen	23,33	intercellular adhesion molecule-1	fibrinogen	3383	2244	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubj|action action|nmod|END_ENTITY	A mitogenic action for fibrinogen mediated through intercellular_adhesion_molecule-1 .
12364868	0	intercellular_adhesion_molecule-1	23,56	interferon-gamma	86,102	intercellular adhesion molecule-1	interferon-gamma	3383	3458	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of histamine on intercellular_adhesion_molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18 .
14766082	0	intercellular_adhesion_molecule-1	91,124	interleukin-1_receptor_antagonist	26,59	intercellular adhesion molecule-1	interleukin-1 receptor antagonist	3383	3557	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The inhibition effect of interleukin-1_receptor_antagonist on interleukin-1_alpha-induced intercellular_adhesion_molecule-1 expression on orbital fibroblasts and adhesion of peripheral blood mononuclear cells -RSB- .
10872602	0	intercellular_adhesion_molecule-1	71,104	interleukin-6	27,40	intercellular adhesion molecule-1	interleukin-6	3383	3569	Gene	Gene	role|amod|START_ENTITY role|nmod|END_ENTITY	The role of amniotic fluid interleukin-6 , and cell adhesion molecules , intercellular_adhesion_molecule-1 and leukocyte_adhesion_molecule-1 , in intra-amniotic_infection .
7914891	0	intercellular_adhesion_molecule-1	25,58	interleukin-6	71,84	intercellular adhesion molecule-1	interleukin-6	3383	3569	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Stimulation of the human intercellular_adhesion_molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element .
12324444	0	intercellular_adhesion_molecule-1	66,99	leukocyte_function-associated_antigen-1	26,65	intercellular adhesion molecule-1	leukocyte function-associated antigen-1	3383	3683	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Force spectroscopy of the leukocyte_function-associated_antigen-1 / intercellular_adhesion_molecule-1 interaction .
3315233	0	intercellular_adhesion_molecule-1	9,42	lymphocyte_function-associated_antigen_1	68,108	intercellular adhesion molecule-1	lymphocyte function-associated antigen 1	3383	3683	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	Purified intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is a ligand for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
9743506	0	intercellular_adhesion_molecule-1	94,127	monocyte_chemotactic_protein-1	27,57	intercellular adhesion molecule-1	monocyte chemotactic protein-1	3383	6347	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Activated platelets induce monocyte_chemotactic_protein-1 secretion and surface expression of intercellular_adhesion_molecule-1 on endothelial cells .
25026345	0	intercellular_adhesion_molecule-1	86,119	p53	130,133	intercellular adhesion molecule-1	p53	3383	7157	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
1356028	0	intercellular_adhesion_molecule-1	22,55	platelet-activating_factor	100,126	intercellular adhesion molecule-1	platelet-activating factor	3383	9768	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|nmod|END_ENTITY	Possible induction of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on endothelial cells by platelet-activating_factor -LRB- PAF -RRB- .
25026345	0	intercellular_adhesion_molecule-1	86,119	tumor_necrosis_factor-a	32,55	intercellular adhesion molecule-1	tumor necrosis factor-a	3383	7124	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
10407627	0	intercellular_adhesion_molecule-1	87,120	tumor_necrosis_factor-alpha	9,36	intercellular adhesion molecule-1	tumor necrosis factor-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulating|dobj|expression factor-beta|acl|regulating factor-beta|compound|END_ENTITY	Roles of tumor_necrosis_factor-alpha and transforming growth factor-beta in regulating intercellular_adhesion_molecule-1 expression on murine peritoneal macrophages infected with M. _ leprae .
10860946	0	intercellular_adhesion_molecule-1	130,163	tumor_necrosis_factor-alpha	18,45	intercellular adhesion molecule-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	expression|amod|START_ENTITY necrosis|dobj|expression necrosis|nsubj|Activation Activation|nmod|receptor-1 receptor-1|amod|END_ENTITY	Activation of p55 tumor_necrosis_factor-alpha receptor-1 coupled to tumor necrosis factor receptor-associated factor 2 stimulates intercellular_adhesion_molecule-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle cells .
17607964	0	intercellular_adhesion_molecule-1	42,75	tumor_necrosis_factor-alpha	229,256	intercellular adhesion molecule-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	-LSB-|nmod|START_ENTITY induced|csubj|-LSB- induced|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
20045926	0	intercellular_adhesion_molecule-1	48,81	tumor_necrosis_factor-alpha	93,120	intercellular adhesion molecule-1	tumor necrosis factor-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Deoxypodophyllotoxin inhibits the expression of intercellular_adhesion_molecule-1 induced by tumor_necrosis_factor-alpha in murine lung epithelial cells .
7910170	0	intercellular_adhesion_molecule-1	14,47	tumor_necrosis_factor-alpha	67,94	intercellular adhesion molecule-1	tumor necrosis factor-alpha	25464(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of intercellular_adhesion_molecule-1 gene expression by tumor_necrosis_factor-alpha , interleukin-1_beta , and interferon-gamma in astrocytes .
7915264	0	intercellular_adhesion_molecule-1	172,205	tumor_necrosis_factor-alpha	21,48	intercellular adhesion molecule-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells lysis|dep|expression increases|nmod|lysis increases|nsubj|END_ENTITY	Transfection-induced tumor_necrosis_factor-alpha increases the susceptibility of human glioma cells to lysis by lymphokine-activated killer cells : continuous expression of intercellular_adhesion_molecule-1 on the glioma cells .
7930472	0	intercellular_adhesion_molecule-1	58,91	tumor_necrosis_factor-alpha	104,131	intercellular adhesion molecule-1	tumor necrosis factor-alpha	25464(Tax:10116)	24835(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY rat|dobj|cells rat|nmod|stimulation stimulation|amod|END_ENTITY	Cultured rat hepatic sinusoidal endothelial cells express intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by tumor_necrosis_factor-alpha or interleukin-1_alpha stimulation .
8102141	0	intercellular_adhesion_molecule-1	103,136	tumor_necrosis_factor-alpha	40,67	intercellular adhesion molecule-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression mediated|dobj|induction mediated|nsubj|END_ENTITY	Histamine and cis-urocanic_acid augment tumor_necrosis_factor-alpha mediated induction of keratinocyte intercellular_adhesion_molecule-1 expression .
9056676	0	intercellular_adhesion_molecule-1	14,47	tumor_necrosis_factor-alpha	56,83	intercellular adhesion molecule-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of intercellular_adhesion_molecule-1 gene by tumor_necrosis_factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50 .
9886187	0	intercellular_adhesion_molecule-1	39,72	tumor_necrosis_factor-alpha	97,124	intercellular adhesion molecule-1	tumor necrosis factor-alpha	15894(Tax:10090)	21926(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY expression|nmod|levels expression|nmod|END_ENTITY	Correlation of increased expression of intercellular_adhesion_molecule-1 , but not high levels of tumor_necrosis_factor-alpha , with lethality of Plasmodium_yoelii 17XL , a rodent model of cerebral_malaria .
9919421	0	intercellular_adhesion_molecule-1	14,47	tumor_necrosis_factor-alpha	125,152	intercellular adhesion molecule-1	tumor necrosis factor-alpha	3383	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 in human coronary endothelial and smooth muscle cells after stimulation with tumor_necrosis_factor-alpha .
24482647	0	intercellular_adhesion_molecule-2	23,56	ICAM-2	58,64	intercellular adhesion molecule-2	ICAM-2	3384	3384	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression analysis of intercellular_adhesion_molecule-2 -LRB- ICAM-2 -RRB- in the context of classical cardiovascular risk factors in acute_coronary_syndrome patients .
15023143	0	intercellular_adhesion_molecule-2	24,57	LFA-1	89,94	intercellular adhesion molecule-2	LFA-1	414387(Tax:9823)	3683	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of pig intercellular_adhesion_molecule-2 and its interaction with human LFA-1 .
7915884	0	intercellular_adhesion_molecule_1	51,84	CD4	30,33	intercellular adhesion molecule 1	CD4	15894(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of monoclonal antibody CD4 on expression of intercellular_adhesion_molecule_1 in renal tissues of ddY mice : a spontaneous animal model of IgA_nephropathy .
7642556	0	intercellular_adhesion_molecule_1	46,79	H2O2_and_tumor_necrosis_factor-alpha	0,36	intercellular adhesion molecule 1	H2O2 and tumor necrosis factor-alpha	3383	7124	Gene	Gene	gene|amod|START_ENTITY activate|dobj|gene activate|nsubj|END_ENTITY	H2O2_and_tumor_necrosis_factor-alpha activate intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter .
10413701	0	intercellular_adhesion_molecule_1	19,52	ICAM-1	54,60	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Vitreous levels of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- as a risk indicator of proliferative_vitreoretinopathy .
11006153	0	intercellular_adhesion_molecule_1	14,47	ICAM-1	49,55	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- on the human oviductal epithelium and mediation of lymphoid cell adherence .
1355484	0	intercellular_adhesion_molecule_1	14,47	ICAM-1	49,55	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- during the development of invasion and/or metastasis of gastric_carcinoma .
16076754	0	intercellular_adhesion_molecule_1	44,77	ICAM-1	79,85	intercellular adhesion molecule 1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Early and long-term effects of radiation on intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in mouse urinary bladder endothelium .
1685745	0	intercellular_adhesion_molecule_1	14,47	ICAM-1	49,55	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in Alzheimer 's _ disease .
16978373	0	intercellular_adhesion_molecule_1	26,59	ICAM-1	61,67	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic influences of the intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene polymorphisms in development of Type_1_diabetes and diabetic_nephropathy .
1722744	0	intercellular_adhesion_molecule_1	14,47	ICAM-1	49,55	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- on human articular cartilage chondrocytes .
19483084	0	intercellular_adhesion_molecule_1	94,127	ICAM-1	129,135	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in endothelial cells .
20647315	0	intercellular_adhesion_molecule_1	48,81	ICAM-1	83,89	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prostaglandin E2/EP1 signaling pathway enhances intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression and cell motility in oral_cancer cells .
2479693	0	intercellular_adhesion_molecule_1	24,57	ICAM-1	59,65	intercellular adhesion molecule 1	ICAM-1	15894(Tax:10090)	15894(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation of the murine intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene .
2576242	0	intercellular_adhesion_molecule_1	61,94	ICAM-1	96,102	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Functional studies of stable L cell transfectants expressing intercellular_adhesion_molecule_1 -LSB- ICAM-1 -RSB- .
2656754	0	intercellular_adhesion_molecule_1	17,50	ICAM-1	52,58	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The induction of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression on human fetal astrocytes by interferon-gamma , _ tumor_necrosis_factor_alpha , lymphotoxin , and interleukin-1 : relevance to intracerebral antigen presentation .
7642556	0	intercellular_adhesion_molecule_1	46,79	ICAM-1	81,87	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	H2O2_and_tumor_necrosis_factor-alpha activate intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter .
7768636	0	intercellular_adhesion_molecule_1	17,50	ICAM-1	52,58	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- on human renal_cell_carcinoma cells by interleukin-4 .
7902311	0	intercellular_adhesion_molecule_1	14,47	ICAM-1	49,55	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 , CD54 -RRB- in colonic epithelial cells .
7911467	0	intercellular_adhesion_molecule_1	120,153	ICAM-1	155,161	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Inhibition of protein_kinase_C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- mRNA by phorbol_esters .
8093883	0	intercellular_adhesion_molecule_1	22,55	ICAM-1	57,63	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	De novo expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 , CD54 -RRB- in pancreas_cancer .
8095960	0	intercellular_adhesion_molecule_1	13,46	ICAM-1	48,54	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in normal human eosinophils by inflammatory cytokines .
8549228	0	intercellular_adhesion_molecule_1	8,41	ICAM-1	43,49	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Soluble intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- antigen in sera of bronchial_asthmatics .
8904994	0	intercellular_adhesion_molecule_1	14,47	ICAM-1	49,55	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression on the human mast-cell line -LRB- HMC -RRB- -1 by inflammatory mediators .
9286030	0	intercellular_adhesion_molecule_1	24,57	ICAM-1	59,65	intercellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Molecular regulation of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in renal_cell_carcinoma .
9329027	0	intercellular_adhesion_molecule_1	32,65	ICAM-1	67,73	intercellular adhesion molecule 1	ICAM-1	25464(Tax:10116)	25464(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Enhanced cytokines delivery and intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- expression in glioma by intracarotid infusion of bradykinin analog , RMP-7 .
23346076	0	intercellular_adhesion_molecule_1	15,48	ICAM1	50,55	intercellular adhesion molecule 1	ICAM1	3383	3383	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of intercellular_adhesion_molecule_1 -LRB- ICAM1 -RRB- with diabetes and diabetic_nephropathy .
11929876	0	intercellular_adhesion_molecule_1	64,97	LFA-1	22,27	intercellular adhesion molecule 1	LFA-1	3383	3689	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in shear flow .
9691914	0	intercellular_adhesion_molecule_1	58,91	NF-kappa_B	13,23	intercellular adhesion molecule 1	NF-kappa B	25464(Tax:10116)	4790	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Mediation by NF-kappa_B of cytokine induced expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- in an intestinal epithelial cell line , a process blocked by proteasome inhibitors .
8106145	0	intercellular_adhesion_molecule_1	61,94	Neu_differentiation_factor	0,26	intercellular adhesion molecule 1	Neu differentiation factor	3383	3084	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Neu_differentiation_factor -LRB- heregulin -RRB- induces expression of intercellular_adhesion_molecule_1 : implications for mammary_tumors .
23576799	0	intercellular_adhesion_molecule_1	16,49	Plasmin	0,7	intercellular adhesion molecule 1	Plasmin	3383	5340	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Plasmin induces intercellular_adhesion_molecule_1 expression in human endothelial cells via nuclear factor-kB/mitogen-activated protein kinases-dependent pathways .
17693933	0	intercellular_adhesion_molecule_1	73,106	TNF-alpha	125,134	intercellular adhesion molecule 1	TNF-alpha	3383	7124	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of adenosine_A2A_receptor inhibits LPS-induced expression of intercellular_adhesion_molecule_1 and production of TNF-alpha in human peripheral blood mononuclear cells .
8970974	0	intercellular_adhesion_molecule_1	36,69	Tax1	87,91	intercellular adhesion molecule 1	Tax1	3383	6900	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Differential transactivation of the intercellular_adhesion_molecule_1 gene promoter by Tax1 and Tax2 of human T-cell_leukemia viruses .
9663488	0	intercellular_adhesion_molecule_1	152,185	Vascular_cell_adhesion_molecule_1	0,33	intercellular adhesion molecule 1	Vascular cell adhesion molecule 1	3383	7412	Gene	Gene	expression|nmod|START_ENTITY regulation|nmod|expression END_ENTITY|dep|regulation	Vascular_cell_adhesion_molecule_1 -LRB- CD106 -RRB- on primary human articular chondrocytes : functional regulation of expression by cytokines and comparison with intercellular_adhesion_molecule_1 -LRB- CD54 -RRB- and very late activation antigen 2 .
11108718	0	intercellular_adhesion_molecule_1	49,82	Vascular_endothelial_growth_factor	0,34	intercellular adhesion molecule 1	Vascular endothelial growth factor	3383	7422	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression of intercellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- , vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- , and E-selectin through nuclear factor-kappa B activation in endothelial cells .
7902093	0	intercellular_adhesion_molecule_1	48,81	tumor_necrosis_factor_alpha	17,44	intercellular adhesion molecule 1	tumor necrosis factor alpha	3383	7124	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Up-regulation by tumor_necrosis_factor_alpha of intercellular_adhesion_molecule_1 expression and function in synovial fibroblasts and its inhibition by glucocorticoids .
9261475	0	intercellular_adhesion_molecule_3	14,47	CDw50	49,54	intercellular adhesion molecule 3	CDw50	3385	3385	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of intercellular_adhesion_molecule_3 -LRB- CDw50 -RRB- on endothelial cells in cutaneous_lymphomas .
22479382	0	intercellular_adhesion_molecule_3	16,49	ICAM-3	51,57	intercellular adhesion molecule 3	ICAM-3	3385	3385	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	RUNX3 regulates intercellular_adhesion_molecule_3 -LRB- ICAM-3 -RRB- expression during macrophage differentiation and monocyte extravasation .
7851905	0	intercellular_adhesion_molecule_3	10,43	ICAM3	45,50	intercellular adhesion molecule 3	ICAM3	3385	3385	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human intercellular_adhesion_molecule_3 -LRB- ICAM3 -RRB- gene is located in the 19p13.2-p13 .3 region , close to the ICAM1 gene .
22479382	0	intercellular_adhesion_molecule_3	16,49	RUNX3	0,5	intercellular adhesion molecule 3	RUNX3	3385	864	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RUNX3 regulates intercellular_adhesion_molecule_3 -LRB- ICAM-3 -RRB- expression during macrophage differentiation and monocyte extravasation .
7506711	0	intercellular_adhesion_molecule_type_1	159,197	E-selectin	147,157	intercellular adhesion molecule type 1	E-selectin	3383	6401	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Estradiol enhances leukocyte binding to tumor_necrosis_factor -LRB- TNF -RRB- - stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin , intercellular_adhesion_molecule_type_1 , and vascular_cell_adhesion_molecule_type_1 .
1360995	0	intercellular_cell_adhesion_molecule-1	137,175	CD4	74,77	intercellular cell adhesion molecule-1	CD4	3383	920	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Costimulation of T cell receptor/CD3-mediated activation of resting human CD4 + T cells by leukocyte function-associated antigen-1 ligand intercellular_cell_adhesion_molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increase of intracellular Ca2 + levels .
11775908	0	intercellular_cell_adhesion_molecule-1	57,95	vascular_cell_adhesion_molecule-1	97,130	intercellular cell adhesion molecule-1	vascular cell adhesion molecule-1	3383	7412	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Inhibitory effects of ligustrazine on the expression of intercellular_cell_adhesion_molecule-1 , vascular_cell_adhesion_molecule-1 in human umbilical vein endothelial cells induced by preeclamptic plasma -RSB- .
17019989	0	intercellulare_adhesion_molecule	37,69	ICAM-1	71,77	intercellulare adhesion molecule	ICAM-1	3383	3383	Gene	Gene	expression|nmod|START_ENTITY evaluation|nmod|expression evaluation|appos|END_ENTITY	-LSB- The evaluation of the expression of intercellulare_adhesion_molecule -LRB- ICAM-1 -RRB- by conjunctival epithelial cells of patients with cystic_fibrosis -RSB- .
15628995	0	interferon	20,30	IFN	32,35	interferon	IFN	3439	3439	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of the interferon -LRB- IFN -RRB- in the therapy .
7568028	0	interferon	63,73	PKR	56,59	interferon	PKR	3439	5610	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity .
23110142	0	interferon-a	55,67	Recombination_activating_gene-2	0,31	interferon-a	Recombination activating gene-2	111654(Tax:10090)	19374(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Recombination_activating_gene-2 regulates CpG-mediated interferon-a production in mouse bone marrow-derived plasmacytoid dendritic cells .
1617156	0	interferon-alpha	48,64	CD69	0,4	interferon-alpha	CD69	111654(Tax:10090)	969	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CD69 is expressed on Daudi cells in response to interferon-alpha .
1614874	0	interferon-alpha	30,46	IRF-1	66,71	interferon-alpha	IRF-1	111654(Tax:10090)	16362(Tax:10090)	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Distinct activation of murine interferon-alpha promoter region by IRF-1 / ISFG-2 and virus_infection .
19058305	0	interferon-alpha-2b	21,40	cyclooxygenase-2	58,74	interferon-alpha-2b	cyclooxygenase-2	3440	5743	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of interferon-alpha-2b on expression of cyclooxygenase-2 and vascular_endothelial_growth_factor in human hepatocellular_carcinoma inoculated in nude_mice .
17505265	0	interferon-alpha2b	16,34	Endostatin	0,10	interferon-alpha2b	Endostatin	3440	80781	Gene	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Endostatin plus interferon-alpha2b therapy for metastatic_melanoma : a novel combination of antiangiogenic and immunomodulatory agents .
2530332	0	interferon-alpha_2a	44,63	interferon-gamma	154,170	interferon-alpha 2a	interferon-gamma	3440	3458	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The synergistic effect of human recombinant interferon-alpha_2a in combination with interferon-gamma and the induction of interferon-alpha_2a receptor by interferon-gamma .
2530332	0	interferon-alpha_2a	44,63	interferon-gamma	84,100	interferon-alpha 2a	interferon-gamma	3440	3458	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|combination combination|nmod|END_ENTITY	The synergistic effect of human recombinant interferon-alpha_2a in combination with interferon-gamma and the induction of interferon-alpha_2a receptor by interferon-gamma .
3257147	0	interferon-alpha_A	32,50	adenosine_deaminase	74,93	interferon-alpha A	adenosine deaminase	3440	100	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Opposite effects of recombinant interferon-alpha_A and deoxycoformycin on adenosine_deaminase activity in the Daudi B lymphoblastoid cell line .
2474543	0	interferon-alpha_A	90,108	protein_kinase_C	13,29	interferon-alpha A	protein kinase C	3440	112476	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	A functional protein_kinase_C is required for induction of 2-5A synthetase by recombinant interferon-alpha_A in Daudi cells .
3294161	0	interferon-beta_2	29,46	hepatocyte_stimulating_factor	75,104	interferon-beta 2	hepatocyte stimulating factor	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Regional localization of the interferon-beta_2 / B-cell_stimulatory_factor_2 / hepatocyte_stimulating_factor gene to human chromosome 7p15-p21 .
16949687	0	interferon-gamma	66,82	AGT	39,42	interferon-gamma	AGT	3458	183	Gene	Gene	transcription|nmod|START_ENTITY transcription|appos|END_ENTITY	Upregulation of human angiotensinogen -LRB- AGT -RRB- gene transcription by interferon-gamma : involvement of the STAT1-binding motif in the AGT promoter .
3112250	0	interferon-gamma	25,41	Angiotensin_II	0,14	interferon-gamma	Angiotensin II	3458	183	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Angiotensin_II regulates interferon-gamma production .
11360653	0	interferon-gamma	37,53	B7-1	79,83	interferon-gamma	B7-1	3458	941	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	-LSB- Phorbol-12-myristate-13-acetate and interferon-gamma synergistic induction of B7-1 expression in ovary_carcinoma cells and immunological value -RSB- .
10477704	0	interferon-gamma	33,49	B7-2	9,13	interferon-gamma	B7-2	3458	942	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Enhanced B7-2 gene expression by interferon-gamma in human monocytic cells is controlled through transcriptional and posttranscriptional mechanisms .
15596057	0	interferon-gamma	38,54	BCL-6	13,18	interferon-gamma	BCL-6	3458	604	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of BCL-6 gene expression by interferon-gamma and identification of an IRE in exon I. BCL-6 is a POZ domain zinc-finger transcription factor that appears to play important roles in the development of the immune system and its regulation .
10964771	0	interferon-gamma	45,61	Bgp1	19,23	interferon-gamma	Bgp1	15978(Tax:10090)	26365(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|dep|receptor	Down-regulation of Bgp1 -LRB- a -RRB- viral receptor by interferon-gamma is related to the antiviral state and resistance to mouse hepatitis virus 3 infection .
16331681	0	interferon-gamma	42,58	C/EBPbeta	115,124	interferon-gamma	C/EBPbeta	3458	1051	Gene	Gene	expression|nmod|START_ENTITY Inhibition|nmod|expression Inhibition|dep|role role|nmod|binding_protein_beta binding_protein_beta|appos|END_ENTITY	Inhibition of collagen gene expression by interferon-gamma : novel role of the CCAAT/enhancer _ binding_protein_beta -LRB- C/EBPbeta -RRB- .
19353522	0	interferon-gamma	66,82	C/EBPbeta	0,9	interferon-gamma	C/EBPbeta	3458	1051	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	C/EBPbeta mediates synergistic upregulation of gene expression by interferon-gamma and tumor_necrosis_factor-alpha in bone marrow-derived mesenchymal stem cells .
11434933	0	interferon-gamma	110,126	C1q	23,26	interferon-gamma	C1q	3458	712	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of membrane C1q in human monocyte-derived macrophages is developmentally regulated and enhanced by interferon-gamma .
12388333	0	interferon-gamma	38,54	CCSP	30,34	interferon-gamma	CCSP	15978(Tax:10090)	22287(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of CCSP by interferon-gamma in vitro and in vivo .
14700442	0	interferon-gamma	78,94	CD23	14,18	interferon-gamma	CD23	3458	2208	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|END_ENTITY	Regulation of CD23 in the chronic inflammatory response in asthma : a role for interferon-gamma and heat_shock_protein_70 in the TH2 environment .
15649266	0	interferon-gamma	79,95	CD25	67,71	interferon-gamma	CD25	3458	3559	Gene	Gene	+|nsubj|START_ENTITY induces|parataxis|+ induces|dobj|recruitment recruitment|nmod|+ +|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
1716521	0	interferon-gamma	34,50	CD28	146,150	interferon-gamma	CD28	3458	940	Gene	Gene	monocytes|amod|START_ENTITY induction|nmod|monocytes induction|dep|mechanism mechanism|nmod|amplification amplification|nmod|activation activation|nmod|pathway pathway|compound|END_ENTITY	Selective induction of B7/BB -1 on interferon-gamma stimulated monocytes : a potential mechanism for amplification of T cell activation through the CD28 pathway .
9472663	0	interferon-gamma	151,167	CD28	183,187	interferon-gamma	CD28	3458	940	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9232450	0	interferon-gamma	70,86	CD31	106,110	interferon-gamma	CD31	3458	5175	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	CD45RA-expressing memory/effector Th cells committed to production of interferon-gamma lack expression of CD31 .
11756175	0	interferon-gamma	146,162	CD34	73,77	interferon-gamma	CD34	3458	947	Gene	Gene	secretion|nmod|START_ENTITY induces|nmod|secretion induces|dobj|cells cells|compound|survival survival|nmod|TF-1 TF-1|compound|END_ENTITY	Human_T-cell_leukemia_virus_type_2 induces survival and proliferation of CD34 -LRB- + -RRB- TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte_macrophage-colony-stimulating_factor .
14745429	0	interferon-gamma	20,36	CD34	72,76	interferon-gamma	CD34	3458	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	In vitro effects of interferon-gamma and tumor_necrosis_factor-alpha on CD34 + bone marrow progenitor cells from aplastic_anemia patients and normal donors .
9163602	0	interferon-gamma	52,68	CD34	123,127	interferon-gamma	CD34	3458	947	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|cells cells|compound|END_ENTITY	Expression and modulation of cellular receptors for interferon-gamma , tumour necrosis factor , and Fas on human bone marrow CD34 + cells .
10233697	0	interferon-gamma	57,73	CD4	112,115	interferon-gamma	CD4	3458	920	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nmod|human human|appos|+ +|compound|END_ENTITY	Interleukin-15 differentially enhances the expression of interferon-gamma and interleukin-4 in activated human -LRB- CD4 + -RRB- T lymphocytes .
10479527	0	interferon-gamma	36,52	CD4	0,3	interferon-gamma	CD4	3458	920	Gene	Gene	predominate|amod|START_ENTITY producing|dobj|predominate T|dep|producing T|nsubj|END_ENTITY	CD4 -LRB- + -RRB- T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary_tuberculosis patients .
10540183	0	interferon-gamma	37,53	CD4	19,22	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY T|dobj|cells T|nsubj|+ +|compound|END_ENTITY	In vitro activated CD4 + T cells from interferon-gamma -LRB- IFN-gamma -RRB- - deficient mice induce intestinal_inflammation in immunodeficient hosts .
10692120	0	interferon-gamma	26,42	CD4	5,8	interferon-gamma	CD4	3458	920	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|cells cells|compound|END_ENTITY	Skin CD4 + T cells produce interferon-gamma in vitro in response to streptococcal antigens in chronic_plaque_psoriasis .
10755571	0	interferon-gamma	104,120	CD4	0,3	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY rejection|nmod|absence mediate|dobj|rejection mediate|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + T cells responsive through the indirect pathway can mediate skin graft rejection in the absence of interferon-gamma .
10809917	0	interferon-gamma	69,85	CD4	131,134	interferon-gamma	CD4	3458	920	Gene	Gene	mRNA|amod|START_ENTITY expressing|dobj|mRNA numbers|acl|expressing +|nsubj|numbers +|compound|END_ENTITY	Increased numbers of mononuclear cells from blood and CSF expressing interferon-gamma mRNA in multiple_sclerosis are from both the CD4 + and the CD8 + subsets .
10895055	0	interferon-gamma	26,42	CD4	89,92	interferon-gamma	CD4	3458	920	Gene	Gene	changes|nmod|START_ENTITY secretion|nsubj|changes secretion|advcl|purified purified|dobj|+ +|compound|END_ENTITY	Age-associated changes in interferon-gamma and interleukin-4 secretion by purified human CD4 + and CD8 + T cells .
11412302	0	interferon-gamma	27,43	CD4	47,50	interferon-gamma	CD4	3458	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Preferential production of interferon-gamma by CD4 + T cells expressing the homing receptor integrin_alpha4 / beta7 .
11852193	0	interferon-gamma	138,154	CD4	89,92	interferon-gamma	CD4	281237(Tax:9913)	407098(Tax:9913)	Gene	Gene	proliferate|dobj|START_ENTITY enriched|xcomp|proliferate enriched|dep|+ +|compound|END_ENTITY	Low molecular weight proteins of Cowdria_ruminantium -LRB- Welgevonden isolate -RRB- induce bovine CD4 + - enriched T-cells to proliferate and produce interferon-gamma .
12525871	0	interferon-gamma	97,113	CD4	139,142	interferon-gamma	CD4	3458	920	Gene	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nmod|clone clone|compound|END_ENTITY	Transforming_growth_factor-beta released by PPD-presenting malignant_mesothelioma cells inhibits interferon-gamma synthesis by an anti-PPD CD4 + T-cell clone .
1370259	0	interferon-gamma	100,116	CD4	21,24	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY increases|parataxis|role increases|nmod|depletion depletion|nmod|T T|compound|END_ENTITY	In vivo depletion of CD4 T cells increases B cell sensitivity to polyclonal activation : the role of interferon-gamma .
1432999	0	interferon-gamma	57,73	CD4	88,91	interferon-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY inhibit|dobj|production inhibit|nmod|positive positive|compound|END_ENTITY	Cyclosporine and chloroquine synergistically inhibit the interferon-gamma production by CD4 positive and CD8 positive synovial T cell clones derived from a patient with rheumatoid_arthritis .
15493262	0	interferon-gamma	8,24	CD4	76,79	interferon-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY Maximal|dobj|production Maximal|nmod|CDw29 CDw29|compound|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
15502111	0	interferon-gamma	44,60	CD4	71,74	interferon-gamma	CD4	3458	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Increased interleukin-4 , interleukin-5 , and interferon-gamma in airway CD4 + and CD8 + T cells in atopic_asthma .
15649266	0	interferon-gamma	79,95	CD4	62,65	interferon-gamma	CD4	3458	920	Gene	Gene	+|nsubj|START_ENTITY induces|parataxis|+ induces|dobj|recruitment recruitment|nmod|+ +|compound|END_ENTITY	Fel d 1-derived T cell peptide therapy induces recruitment of CD4 + CD25 + ; CD4 + interferon-gamma + T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects .
15829292	0	interferon-gamma	29,45	CD4	146,149	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppression|nmod|production paralleled|nsubj|suppression paralleled|nmod|cells cells|compound|END_ENTITY	Tumor-induced suppression of interferon-gamma production and enhancement of interleukin-10 production by natural killer -LRB- NK -RRB- cells : paralleled to CD4 + T cells .
15935691	0	interferon-gamma	34,50	CD4	77,80	interferon-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Correlation between intracellular interferon-gamma -LRB- IFN-gamma -RRB- production by CD4 + and CD8 + lymphocytes and IFN-gamma gene polymorphism in patients with type 2 diabetes_mellitus and latent autoimmune diabetes of adults -LRB- LADA -RRB- .
16162267	0	interferon-gamma	40,56	CD4	80,83	interferon-gamma	CD4	3458	920	Gene	Gene	retention|amod|START_ENTITY retention|nmod|cells cells|compound|END_ENTITY	A novel mechanism of immune regulation : interferon-gamma regulates retention of CD4 T cells during delayed_type_hypersensitivity .
1672641	0	interferon-gamma	133,149	CD4	65,68	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	secrete|dobj|START_ENTITY lines|acl:relcl|secrete lines|compound|END_ENTITY	Exacerbation of experimental murine cutaneous_leishmaniasis with CD4 + Leishmania_major-specific T cell lines or clones which secrete interferon-gamma and mediate parasite-specific delayed-type_hypersensitivity .
17533522	0	interferon-gamma	14,30	CD4	63,66	interferon-gamma	CD4	3458	920	Gene	Gene	production|compound|START_ENTITY Expression|nmod|production Expression|nmod|cells cells|compound|END_ENTITY	Expression of interferon-gamma and interleukin-4 production in CD4 + T cells in patients with chronic_heart_failure .
17617612	0	interferon-gamma	7,23	CD4	56,59	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|+ +|compound|END_ENTITY	Direct interferon-gamma signaling dramatically enhances CD4 + and CD8 + T cell memory .
18179752	0	interferon-gamma	53,69	CD4	99,102	interferon-gamma	CD4	3458	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Effect of coronary percutaneous revascularization on interferon-gamma and interleukin-10 producing CD4 + T cells during acute myocardial_infarction .
19003102	0	interferon-gamma	76,92	CD4	50,53	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY prime|xcomp|produce prime|xcomp|ve ve|dobj|+ +|compound|END_ENTITY	Murine Peyer 's patch dendritic cells prime na ve CD4 -LRB- + -RRB- T cells to produce interferon-gamma .
19909079	0	interferon-gamma	69,85	CD4	41,44	interferon-gamma	CD4	3458	920	Gene	Gene	produce|dobj|START_ENTITY cells|acl:relcl|produce T|dobj|cells T|nsubj|increase increase|nmod|frequency frequency|nmod|END_ENTITY	Age-related increase in the frequency of CD4 -LRB- + -RRB- T cells that produce interferon-gamma in response to staphylococcal enterotoxin B during childhood .
19939720	0	interferon-gamma	58,74	CD4	129,132	interferon-gamma	CD4	3458	920	Gene	Gene	relapsing|nmod|START_ENTITY relapsing|nmod|patient patient|nmod|syndrome syndrome|compound|END_ENTITY	Treatment of relapsing Mycobacterium_avium infection with interferon-gamma and interleukin-2 in an HIV-negative patient with low CD4 syndrome .
20178622	0	interferon-gamma	75,91	CD4	10,13	interferon-gamma	CD4	3458	920	Gene	Gene	cooperation|nmod|START_ENTITY enhance|nmod|cooperation +|ccomp|enhance +|nsubj|END_ENTITY	Activated CD4 + T cells enhance radiation effect through the cooperation of interferon-gamma and TNF-alpha .
20634047	0	interferon-gamma	10,26	CD4	46,49	interferon-gamma	CD4	3458	920	Gene	Gene	release|amod|START_ENTITY Detecting|dobj|release Detecting|nmod|T-cells T-cells|compound|END_ENTITY	Detecting interferon-gamma release from human CD4 T-cells using surface plasmon resonance .
2122929	0	interferon-gamma	96,112	CD4	57,60	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Cytostasis Cytostasis|nmod|tumours tumours|nmod|clone clone|compound|END_ENTITY	Cytostasis of different tumours by a murine PPD-reactive CD4 + T lymphocyte clone is mediated by interferon-gamma and tumour_necrosis_factor alone or synergistically .
2523864	0	interferon-gamma	100,116	CD4	160,163	interferon-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY restricted|nsubjpass|production restricted|nmod|IL-2 IL-2|acl|activated activated|dobj|R R|nummod|+45 +45|compound|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
2523864	0	interferon-gamma	100,116	CD4	23,26	interferon-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY restricted|nsubjpass|production promoted|advcl|restricted T|parataxis|promoted T|nsubj|Proliferation Proliferation|nmod|+ +|compound|END_ENTITY	Proliferation of human CD4 +45 R + and CD4 +45 R - T helper cells is promoted by both IL-2 and IL-4 while interferon-gamma production is restricted to IL-2 activated CD4 +45 R - T cells .
7522637	0	interferon-gamma	93,109	CD4	17,20	interferon-gamma	CD4	3458	920	Gene	Gene	secretion|amod|START_ENTITY inducing|dobj|secretion upregulates|advcl|inducing upregulates|nsubj|Cross-linking Cross-linking|nmod|molecules molecules|nummod|END_ENTITY	Cross-linking of CD4 molecules upregulates Fas_antigen expression in lymphocytes by inducing interferon-gamma and tumor_necrosis_factor-alpha secretion .
7583443	0	interferon-gamma	80,96	CD4	0,3	interferon-gamma	CD4	3458	920	Gene	Gene	amounts|nmod|START_ENTITY increased|dobj|amounts increased|nsubj|+ +|compound|END_ENTITY	CD4 + and CD8 + lymphocytes of patients with AIDS synthesize increased amounts of interferon-gamma .
7605995	0	interferon-gamma	25,41	CD4	80,83	interferon-gamma	CD4	3458	920	Gene	Gene	START_ENTITY|appos|chemotactic chemotactic|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Cytokine loops involving interferon-gamma and IP-10 , a cytokine chemotactic for CD4 + lymphocytes : an explanation for the epidermotropism of cutaneous_T-cell_lymphoma ?
7657839	0	interferon-gamma	17,33	CD4	79,82	interferon-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY Priming|nmod|production induced|csubj|Priming induced|nmod|clones clones|amod|interleukin-12 interleukin-12|nmod|+ +|compound|END_ENTITY	Priming for high interferon-gamma production induced by interleukin-12 in both CD4 + and CD8 + T cell clones from HIV-infected patients .
8101473	0	interferon-gamma	137,153	CD4	31,34	interferon-gamma	CD4	3458	920	Gene	Gene	targets|nmod|START_ENTITY assay|nmod|targets T|nmod|assay T|nsubj|Detection Detection|nmod|cytotoxic cytotoxic|compound|END_ENTITY	Detection of melanoma-reactive CD4 + HLA-class I-restricted cytotoxic T cell clones with long-term assay and pretreatment of targets with interferon-gamma .
8537685	0	interferon-gamma	126,142	CD4	41,44	interferon-gamma	CD4	3458	920	Gene	Gene	treated|nmod|START_ENTITY keratinocytes|acl|treated lymphocyte|nmod|keratinocytes lymphocyte|nsubj|targets targets|nmod|END_ENTITY	Herpes simplex virus protein targets for CD4 and CD8 lymphocyte cytotoxicity in cultured epidermal keratinocytes treated with interferon-gamma .
8552982	0	interferon-gamma	9,25	CD4	36,39	interferon-gamma	CD4	3458	920	Gene	Gene	START_ENTITY|acl|producing producing|dobj|+ +|compound|END_ENTITY	Specific interferon-gamma producing CD4 + and CD8 + T cells after autologous EBV-B stimulation : the necessity of restimulation .
8676077	0	interferon-gamma	82,98	CD4	28,31	interferon-gamma	CD4	3458	920	Gene	Gene	production|nmod|START_ENTITY primes|nmod|production primes|dobj|END_ENTITY	Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10 .
8826970	0	interferon-gamma	73,89	CD4	5,8	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY produce|nsubj|+ +|compound|END_ENTITY	Both CD4 + and CD8 + T-cells in syngeneic islet grafts in NOD mice produce interferon-gamma during beta-cell destruction .
9466535	0	interferon-gamma	77,93	CD4	0,3	interferon-gamma	CD4	3458	920	Gene	Gene	production|amod|START_ENTITY have|dobj|production have|nsubj|lymphocytes lymphocytes|compound|END_ENTITY	CD4 T lymphocytes from patients with chronic_fatigue_syndrome have decreased interferon-gamma production and increased sensitivity to dexamethasone .
9616216	0	interferon-gamma	138,154	CD4	122,125	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|appos|START_ENTITY T|dep|cells T|compound|END_ENTITY	Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4 -LRB- + -RRB- T cells , interferon-gamma , and CTLA4 .
9824051	0	interferon-gamma	140,156	CD4	10,13	interferon-gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	secreting|dobj|START_ENTITY associated|xcomp|secreting cells|acl|associated cells|compound|END_ENTITY	Cytotoxic CD4 + T cells associated with the expression of major histocompatibility complex class II antigen of mouse myeloma cells secreting interferon-gamma are cytolytic in vitro and tumoricidal in vivo .
9856819	0	interferon-gamma	35,51	CD4	113,116	interferon-gamma	CD4	3458	920	Gene	Gene	cells|amod|START_ENTITY Identification|nmod|cells Identification|dep|localization localization|nmod|+ +|compound|END_ENTITY	Identification and quantitation of interferon-gamma producing T cells in psoriatic lesions : localization to both CD4 + and CD8 + subsets .
9889405	0	interferon-gamma	42,58	CD4	76,79	interferon-gamma	CD4	25712(Tax:10116)	24932(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY analysis|nmod|synthesis analysis|nmod|cells cells|compound|END_ENTITY	Flow cytometric analysis of intracellular interferon-gamma synthesis in rat CD4 T cells .
10383394	0	interferon-gamma	75,91	CD44	0,4	interferon-gamma	CD44	3458	960	Gene	Gene	binding|nmod|START_ENTITY mediates|dobj|binding mediates|nsubj|END_ENTITY	CD44 , a cell surface chondroitin sulfate proteoglycan , mediates binding of interferon-gamma and some of its biological effects on human vascular smooth muscle cells .
10211099	0	interferon-gamma	29,45	CD46	90,94	interferon-gamma	CD46	3458	4179	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and regulation by interferon-gamma of the membrane-bound complement regulators CD46 -LRB- MCP -RRB- , CD55 -LRB- DAF -RRB- and CD59 in gastrointestinal_tumours .
20231901	0	interferon-gamma	57,73	CD56	86,90	interferon-gamma	CD56	3458	4684	Gene	Gene	response|amod|START_ENTITY IL-12-mediated|dobj|response IL-12-mediated|nmod|cells cells|compound|END_ENTITY	Upregulation of SOCS-3 and PIAS-3 impairs IL-12-mediated interferon-gamma response in CD56 T cells in HCV-infected heroin users .
9194640	0	interferon-gamma	56,72	CD56	84,88	interferon-gamma	CD56	3458	4684	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Interleukin-12 - and interleukin-2-stimulated release of interferon-gamma by uterine CD56 + + large granular lymphocytes is amplified by decidual macrophages .
11167992	0	interferon-gamma	100,116	CD8	143,146	interferon-gamma	CD8	3458	925	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Patients with inflammatory_bowel_disease -LRB- IBD -RRB- reveal increased induction capacity of intracellular interferon-gamma -LRB- IFN-gamma -RRB- in peripheral CD8 + lymphocytes co-cultured with intestinal epithelial cells .
11380612	0	interferon-gamma	99,115	CD8	10,13	interferon-gamma	CD8	15978(Tax:10090)	925	Gene	Gene	levels|nmod|START_ENTITY producing|dobj|levels cells|acl|producing cells|nsubj|cells cells|compound|END_ENTITY	Epidermal CD8 + T cells in chronic plaque_psoriasis are Tc1 cells producing heterogeneous levels of interferon-gamma .
11972627	0	interferon-gamma	67,83	CD8	87,90	interferon-gamma	CD8	3458	925	Gene	Gene	production|nmod|START_ENTITY enhance|dobj|production enhance|nmod|+ +|compound|END_ENTITY	Products from human mast cell line cells enhance the production of interferon-gamma by CD8 + and CD4 + T cells .
12828563	0	interferon-gamma	39,55	CD8	110,113	interferon-gamma	CD8	3458	925	Gene	Gene	signalling|nmod|START_ENTITY necrosis|nsubj|signalling necrosis|dobj|cells cells|compound|END_ENTITY	Aberrant T-cell receptor signalling of interferon-gamma - and tumour necrosis factor-alpha-producing cytotoxic CD8 + Vdelta1/Vbeta16 T cells in a patient with chronic neutropenia .
1330577	0	interferon-gamma	38,54	CD8	88,91	interferon-gamma	CD8	3458	925	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nmod|cells cells|amod|END_ENTITY	The viral superantigen Mls-1a induces interferon-gamma secretion by specifically primed CD8 + cells but fails to trigger cytotoxicity .
15059848	0	interferon-gamma	100,116	CD8	70,73	interferon-gamma	CD8	3458	925	Gene	Gene	producing|dobj|START_ENTITY cells|acl|producing cells|amod|mediated mediated|nmod|subset subset|nmod|T T|compound|END_ENTITY	HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8 -LRB- + -RRB- T cells producing both interferon-gamma and tumor_necrosis_factor-alpha .
17589293	0	interferon-gamma	113,129	CD8	63,66	interferon-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY control|nmod|production fail|xcomp|control fail|nsubj|cells cells|nummod|END_ENTITY	Human_papillomavirus_16 E6-specific CD45RA + CCR7 + high avidity CD8 + T cells fail to control tumor growth despite interferon-gamma production in patients with cervical_cancer .
1902247	0	interferon-gamma	65,81	CD8	144,147	interferon-gamma	CD8	3458	925	Gene	Gene	receptors|compound|START_ENTITY levels|nmod|receptors levels|nmod|protein protein|compound|END_ENTITY	Immune cell activation in melioidosis : increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein .
19100424	0	interferon-gamma	60,76	CD8	31,34	interferon-gamma	CD8	3458	925	Gene	Gene	impairment|amod|START_ENTITY display|dobj|impairment T|ccomp|display T|nsubj|END_ENTITY	Human_cytomegalovirus specific CD8 -LRB- + -RRB- T lymphocytes display interferon-gamma secretion impairment in kidney transplant recipients with pp65 antigenemia .
7769110	0	interferon-gamma	78,94	CD8	50,53	interferon-gamma	CD8	3458	925	Gene	Gene	mediated|nmod|START_ENTITY +|ccomp|mediated +|nsubj|Inhibition Inhibition|nmod|responses responses|nmod|END_ENTITY	Inhibition of T cell responses by activated human CD8 + T cells is mediated by interferon-gamma and is defective in chronic_progressive_multiple_sclerosis .
8611751	0	interferon-gamma	65,81	CD8	25,28	interferon-gamma	CD8	3458	925	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production clone|acl:relcl|inhibits T|dobj|clone T|nsubj|+ +|compound|END_ENTITY	Alpha s1-casein-specific CD8 + T cell clone that inhibits its own interferon-gamma production by producing interleukin-10 .
9255980	0	interferon-gamma	54,70	CD8	99,102	interferon-gamma	CD8	3458	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Enhancing effect of interleukin-4 on the secretion of interferon-gamma by alpha s1-casein-specific CD8 + T cells .
9472663	0	interferon-gamma	151,167	CD8	18,21	interferon-gamma	CD8	3458	925	Gene	Gene	production|nmod|START_ENTITY abnormalities|nmod|production defect|dep|abnormalities defect|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
9472663	0	interferon-gamma	151,167	CD8	228,231	interferon-gamma	CD8	3458	925	Gene	Gene	production|nmod|START_ENTITY abnormalities|nmod|production defect|dep|abnormalities defect|dep|+ +|compound|END_ENTITY	Primary defect in CD8 + lymphocytes in the antibody deficiency_disease -LRB- common_variable_immunodeficiency -RRB- : abnormalities in intracellular production of interferon-gamma -LRB- IFN-gamma -RRB- in CD28 + -LRB- ` cytotoxic ' -RRB- and CD28 - -LRB- ` suppressor ' -RRB- CD8 + subsets .
10089905	0	interferon-gamma	67,83	CD95	13,17	interferon-gamma	CD95	3458	355	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|Fas_antigen Fas_antigen|appos|END_ENTITY	Fas_antigen -LRB- CD95 -RRB- in pure erythroid cell line AS-E2 is induced by interferon-gamma and tumor_necrosis_factor-alpha and potentiates apoptotic death .
10227428	0	interferon-gamma	88,104	CD95	41,45	interferon-gamma	CD95	3458	355	Gene	Gene	cells|amod|START_ENTITY _|dep|cells _|dep|treatment treatment|acl:relcl|enhances enhances|dobj|END_ENTITY	Interferon _ -LRB- IFN -RRB- - beta treatment enhances CD95 and interleukin_10 expression but reduces interferon-gamma producing T cells in MS patients .
10516755	0	interferon-gamma	62,78	CD95	14,18	interferon-gamma	CD95	3458	355	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of CD95 expression and CD95-mediated cell death by interferon-gamma in acute_lymphoblastic_leukemia with chromosomal translocation t -LRB- 4 ; 11 -RRB- .
14872492	0	interferon-gamma	42,58	CD95	14,18	interferon-gamma	CD95	3458	355	Gene	Gene	signaling|nmod|START_ENTITY apoptotic|acl|signaling apoptotic|nummod|END_ENTITY	Inhibition of CD95 apoptotic signaling by interferon-gamma in human osteoarthritic chondrocytes is associated with increased expression of FLICE inhibitory protein .
9763578	0	interferon-gamma	52,68	CD95	11,15	interferon-gamma	CD95	3458	355	Gene	Gene	activated|nmod|START_ENTITY apoptosis|acl:relcl|activated Fas/APO|dep|apoptosis Fas/APO|appos|END_ENTITY	Fas/APO -1 -LRB- CD95 -RRB- - mediated apoptosis is activated by interferon-gamma and interferon - in interleukin-6 -LRB- IL-6 -RRB- - dependent and IL-6-independent multiple_myeloma cell lines .
9935158	0	interferon-gamma	92,108	CD95	14,18	interferon-gamma	CD95	3458	355	Gene	Gene	_|nmod|START_ENTITY _|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of CD95 -LRB- Apo-1 / Fas -RRB- _ ligand and receptor expression in squamous-cell_carcinoma by interferon-gamma and cisplatin .
17991736	0	interferon-gamma	15,31	CIITA	0,5	interferon-gamma	CIITA	3458	4261	Gene	Gene	repression|amod|START_ENTITY mediates|dobj|repression mediates|nsubj|END_ENTITY	CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules .
15196002	0	interferon-gamma	54,70	Cystatin_SA	0,11	interferon-gamma	Cystatin SA	3458	1470	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Cystatin_SA , a cysteine proteinase inhibitor , induces interferon-gamma expression in CD4-positive T cells .
10089905	0	interferon-gamma	67,83	Fas_antigen	0,11	interferon-gamma	Fas antigen	3458	355	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Fas_antigen -LRB- CD95 -RRB- in pure erythroid cell line AS-E2 is induced by interferon-gamma and tumor_necrosis_factor-alpha and potentiates apoptotic death .
7522637	0	interferon-gamma	93,109	Fas_antigen	43,54	interferon-gamma	Fas antigen	3458	355	Gene	Gene	secretion|amod|START_ENTITY inducing|dobj|secretion upregulates|advcl|inducing upregulates|dobj|expression expression|amod|END_ENTITY	Cross-linking of CD4 molecules upregulates Fas_antigen expression in lymphocytes by inducing interferon-gamma and tumor_necrosis_factor-alpha secretion .
9829628	0	interferon-gamma	60,76	Fas_antigen	28,39	interferon-gamma	Fas antigen	15978(Tax:10090)	14102(Tax:10090)	Gene	Gene	liver|amod|START_ENTITY expressions|nmod|liver expressions|amod|END_ENTITY	Induction of Fas ligand and Fas_antigen mRNA expressions in interferon-gamma transgenic mouse liver .
9195204	0	interferon-gamma	40,56	Growth_hormone	0,14	interferon-gamma	Growth hormone	3458	2688	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Growth_hormone stimulates production of interferon-gamma by human peripheral mononuclear cells .
19079332	0	interferon-gamma	106,122	Guanylate-binding_protein-1	0,27	interferon-gamma	Guanylate-binding protein-1	3458	2633	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Guanylate-binding_protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon-gamma and regulates barrier function through effects on apoptosis .
6420170	0	interferon-gamma	17,33	H-2_and_Ia	51,61	interferon-gamma	H-2 and Ia	15978(Tax:10090)	111364(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of cloned interferon-gamma on expression of H-2_and_Ia antigens on cell lines of hemopoietic , lymphoid , epithelial , fibroblastic and neuronal origin .
2122936	0	interferon-gamma	109,125	HLA_class_I_antigen	8,27	interferon-gamma	HLA class I antigen	3458	100507436	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Soluble HLA_class_I_antigen secretion by normal lymphocytes : relationship with cell activation and effect of interferon-gamma .
10050664	0	interferon-gamma	101,117	ICAM-1	47,53	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|molecules molecules|amod|END_ENTITY	Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium : regulation by interferon-gamma .
10975729	0	interferon-gamma	104,120	ICAM-1	51,57	interferon-gamma	ICAM-1	25712(Tax:10116)	25464(Tax:10116)	Gene	Gene	comparison|nmod|START_ENTITY Upregulation|dep|comparison Upregulation|nmod|END_ENTITY	Upregulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- on rat Schwann cells in vitro : comparison of interferon-gamma , tumor_necrosis_factor-alpha and interleukin-1 .
15212674	0	interferon-gamma	92,108	ICAM-1	66,72	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The differential expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and regulation by interferon-gamma during the pathogenesis of endometriosis .
16695974	0	interferon-gamma	14,30	ICAM-1	48,54	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Activation by interferon-gamma of expression of ICAM-1 and MHC_class_II_antigens in tumour cells from colorectal_carcinomas .
1688067	0	interferon-gamma	14,30	ICAM-1	124,130	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	melanoma-associated_antigen|amod|START_ENTITY Cloning|nmod|melanoma-associated_antigen Cloning|dep|identity identity|nmod|END_ENTITY	Cloning of an interferon-gamma regulated human melanoma-associated_antigen : identity to the intercellular adhesion molecule ICAM-1 .
1982067	0	interferon-gamma	105,121	ICAM-1	63,69	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	crucial|nmod|START_ENTITY crucial|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Activation of protein kinase C is crucial in the regulation of ICAM-1 expression on endothelial cells by interferon-gamma .
7907595	0	interferon-gamma	37,53	ICAM-1	132,138	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	proteins|amod|START_ENTITY proteins|nmod|promoter promoter|amod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|dep|END_ENTITY	Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- gene promoter controls the pattern of expression on epithelial cells .
7908588	0	interferon-gamma	46,62	ICAM-1	105,111	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	toxin|nmod|START_ENTITY Effects|nmod|toxin stimulated|nsubj|Effects stimulated|dobj|staining staining|nmod|formation formation|amod|END_ENTITY	Effects of pertussis and cholera toxin on the interferon-gamma stimulated immunocytochemical staining of ICAM-1 and inositol_phosphate formation in a human renal_carcinoma cell line .
7915555	0	interferon-gamma	149,165	ICAM-1	107,113	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	shedding|nmod|START_ENTITY shedding|nsubj|regulation regulation|nmod|END_ENTITY	Various cytokines modulate ICAM-1 shedding on melanoma - and CTCL-derived cell lines : inverse regulation of ICAM-1 shedding in a S zary cell line by interferon-gamma .
7915555	0	interferon-gamma	149,165	ICAM-1	27,33	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	shedding|nmod|START_ENTITY modulate|parataxis|shedding modulate|dobj|END_ENTITY	Various cytokines modulate ICAM-1 shedding on melanoma - and CTCL-derived cell lines : inverse regulation of ICAM-1 shedding in a S zary cell line by interferon-gamma .
8096438	0	interferon-gamma	118,134	ICAM-1	59,65	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	cells|nmod|START_ENTITY protein|nmod|cells expression|dep|protein expression|nmod|END_ENTITY	Amplified expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and M -LRB- r -RRB- 40K protein by DLD-1 colon_tumor cells by interferon-gamma .
8103344	0	interferon-gamma	32,48	ICAM-1	112,118	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	protein_kinase_C|nmod|START_ENTITY expression|amod|protein_kinase_C expression|nmod|END_ENTITY	Role of protein_kinase_C during interferon-gamma - and phorbol_ester-stimulated immunocytochemical expression of ICAM-1 in human renal_carcinoma cells .
8605704	0	interferon-gamma	129,145	ICAM-1	186,192	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	START_ENTITY|nmod|enhancement enhancement|nmod|expression expression|nmod|END_ENTITY	Induction of inflammatory cytokines in effusion cavity by OK-432 injection therapy for patients with malignant_effusion : role of interferon-gamma in enhancement of surface expression of ICAM-1 on tumor cells in vivo .
8608649	0	interferon-gamma	179,195	ICAM-1	152,158	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	interrupted|nmod|START_ENTITY interrupted|nsubjpass|proliferation proliferation|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- - mediated inhibition of glial cell proliferation and down-regulation of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- are interrupted by interferon-gamma -LRB- IFN-gamma -RRB- .
8670729	0	interferon-gamma	83,99	ICAM-1	66,72	interferon-gamma	ICAM-1	25712(Tax:10116)	25464(Tax:10116)	Gene	Gene	surface|nmod|START_ENTITY surface|dobj|upregulation upregulation|nmod|molecule-1 molecule-1|appos|END_ENTITY	Ocular surface upregulation of intercellular adhesive molecule-1 -LRB- ICAM-1 -RRB- by local interferon-gamma -LRB- IFN-gamma -RRB- in the rat .
8869681	0	interferon-gamma	81,97	ICAM-1	53,59	interferon-gamma	ICAM-1	3458	3383	Gene	Gene	factor-alpha|compound|START_ENTITY modulated|nmod|factor-alpha modulated|advmod|contrary contrary|nmod|END_ENTITY	The vitronectin receptor alpha-V beta-3 , contrary to ICAM-1 , is not modulated by interferon-gamma and tumour necrosis factor-alpha on melanoma cell lines .
11309299	0	interferon-gamma	10,26	IFN-gamma	28,37	interferon-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role of interferon-gamma -LRB- IFN-gamma -RRB- in tumor immunity : T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice .
12909406	0	interferon-gamma	31,47	IFN-gamma	49,58	interferon-gamma	IFN-gamma	281237(Tax:9913)	281237(Tax:9913)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Analysis of repeated tests for interferon-gamma -LRB- IFN-gamma -RRB- response and faecal_excretion for diagnosis of subclinical paratuberculosis in Danish cattle .
1318071	0	interferon-gamma	74,90	IFN-gamma	92,101	interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interferon-alpha -LRB- IFN-alpha -RRB- and interferon-gamma -LRB- IFN-gamma -RRB- receptors on human normal and scleroderma dermal fibroblasts in vitro .
15376464	0	interferon-gamma	11,27	IFN-gamma	29,38	interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	A study on interferon-gamma -LRB- IFN-gamma -RRB- response by T cells stimulated by hepatitis_B virus core antigen .
8287610	0	interferon-gamma	28,44	IFN-gamma	46,55	interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and secretion of interferon-gamma -LRB- IFN-gamma -RRB- in children with atopic_dermatitis .
8608632	0	interferon-gamma	14,30	IFN-gamma	32,41	interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-10 , IL-12 and transforming growth factor-beta -LRB- TGF-beta -RRB- mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid_arthritis -LRB- RA -RRB- .
9099937	0	interferon-gamma	28,44	IFN-gamma	46,55	interferon-gamma	IFN-gamma	25712(Tax:10116)	25712(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cellular mRNA expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- in rats nasally tolerized against experimental autoimmune_myasthenia_gravis -LRB- EAMG -RRB- .
9276525	0	interferon-gamma	33,49	IFN-gamma	51,60	interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hyperinducible expression of the interferon-gamma -LRB- IFN-gamma -RRB- gene and its suppression in systemic_lupus_erythematosus -LRB- SLE -RRB- .
9528891	0	interferon-gamma	41,57	IFN-gamma	59,68	interferon-gamma	IFN-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Essential pathogenic role for endogenous interferon-gamma -LRB- IFN-gamma -RRB- during disease onset phase of murine experimental_autoimmune_orchitis .
9933441	0	interferon-gamma	11,27	IFN-gamma	29,38	interferon-gamma	IFN-gamma	3458	3458	Gene	Gene	Th1|dep|START_ENTITY Th1|appos|END_ENTITY	Th1 -LRB- IL-2 , interferon-gamma -LRB- IFN-gamma -RRB- -RRB- and Th2 -LRB- IL-10 , IL-4 -RRB- cytokine production by peripheral blood mononuclear cells -LRB- PBMC -RRB- from patients with systemic_lupus_erythematosus -LRB- SLE -RRB- .
9058314	0	interferon-gamma	15,31	IFNG	38,42	interferon-gamma	IFNG	3458	3458	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of an interferon-gamma gene -LRB- IFNG -RRB- polymorphism in Danish and Finnish insulin-dependent_diabetes_mellitus -LRB- IDDM -RRB- patients and control subjects .
6820888	0	interferon-gamma	68,84	IFN_gamma	86,95	interferon-gamma	IFN gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Antitumor effect of OK-432 -LRB- 1 -RRB- -- antitumor effect of OK-432 induced interferon-gamma -LRB- IFN_gamma -RRB- -RSB- .
10590034	0	interferon-gamma	16,32	IGF-I	0,5	interferon-gamma	IGF-I	3458	3479	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	IGF-I increases interferon-gamma and IL-6 mRNA expression and protein production in neonatal mononuclear cells .
19929594	0	interferon-gamma	73,89	IKK-beta	9,17	interferon-gamma	IKK-beta	15978(Tax:10090)	16150(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of IKK-beta , IRF1 , and p65 in the activation of chemokine genes by interferon-gamma .
8608632	0	interferon-gamma	14,30	IL-10	44,49	interferon-gamma	IL-10	3458	3586	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|mRNA mRNA|amod|END_ENTITY	Expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-10 , IL-12 and transforming growth factor-beta -LRB- TGF-beta -RRB- mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid_arthritis -LRB- RA -RRB- .
19913506	0	interferon-gamma	62,78	IL-11	0,5	interferon-gamma	IL-11	3458	3589	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	IL-11 expression in retinal and corneal cells is regulated by interferon-gamma .
9626334	0	interferon-gamma	14,30	IL-1_receptor_antagonist	72,96	interferon-gamma	IL-1 receptor antagonist	3458	3557	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Modulation by interferon-gamma of the production and gene expression of IL-1_receptor_antagonist in human neutrophils .
10566657	0	interferon-gamma	201,217	IL-4	118,122	interferon-gamma	IL-4	3458	3565	Gene	Gene	production|amod|START_ENTITY increases|nmod|production increases|nmod|increases increases|appos|END_ENTITY	Effect of radioactive iodine therapy on cytokine production in Graves ' _ disease : transient increases in interleukin-4 -LRB- IL-4 -RRB- , IL-6 , IL-10 , and tumor_necrosis_factor-alpha , with longer term increases in interferon-gamma production .
1401997	0	interferon-gamma	99,115	IL-4	9,13	interferon-gamma	IL-4	3458	3565	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Enhanced IL-4 production and IL-4_receptor expression in atopic_dermatitis and their modulation by interferon-gamma .
1907531	0	interferon-gamma	12,28	IL-4	56,60	interferon-gamma	IL-4	3458	3565	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|receptors receptors|compound|END_ENTITY	Recombinant interferon-gamma inhibits the expression of IL-4 receptors on human lymphocytes .
7542576	0	interferon-gamma	66,82	IL-4	96,100	interferon-gamma	IL-4	3458	3565	Gene	Gene	expressing|dobj|START_ENTITY present|advcl|expressing present|nsubj|factor-beta factor-beta|compound|END_ENTITY	High numbers of autoantigen-reactive mononuclear cells expressing interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- are present in cord blood .
9677601	0	interferon-gamma	25,41	IL-4	9,13	interferon-gamma	IL-4	3458	3565	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Enhanced IL-4 but normal interferon-gamma production in children with isolated IgE_mediated_food_hypersensitivity .
10566657	0	interferon-gamma	201,217	IL-6	125,129	interferon-gamma	IL-6	3458	3569	Gene	Gene	production|amod|START_ENTITY increases|nmod|production increases|nmod|increases increases|appos|END_ENTITY	Effect of radioactive iodine therapy on cytokine production in Graves ' _ disease : transient increases in interleukin-4 -LRB- IL-4 -RRB- , IL-6 , IL-10 , and tumor_necrosis_factor-alpha , with longer term increases in interferon-gamma production .
7879703	0	interferon-gamma	80,96	IL-6	142,146	interferon-gamma	IL-6	3458	3569	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Human atherosclerotic_abdominal_aortic_aneurysms produce interleukin -LRB- IL -RRB- -6 and interferon-gamma but not IL-2 and IL-4 : the possible role for IL-6 and interferon-gamma in vascular inflammation .
1899303	0	interferon-gamma	57,73	INF-gamma	75,84	interferon-gamma	INF-gamma	3458	3458	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The use of polymerase chain reaction -LRB- PCR -RRB- for assessing interferon-gamma -LRB- INF-gamma -RRB- mRNA levels in human lymphocytes .
22240255	0	interferon-gamma	76,92	IRF1	103,107	interferon-gamma	IRF1	3458	3659	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene .
1289407	0	interferon-gamma	67,83	Interferon-alpha/beta	0,21	interferon-gamma	Interferon-alpha/beta	15978(Tax:10090)	15974(Tax:10090)	Gene	Gene	synergize|nmod|START_ENTITY synergize|nsubj|END_ENTITY	Interferon-alpha/beta , pentoxifylline , and caffeine synergize with interferon-gamma to induce major histocompatibility complex class I expression on a constitutively class I-negative murine tumor cell line .
12545159	0	interferon-gamma	57,73	Interferon_regulatory_factor-1	0,30	interferon-gamma	Interferon regulatory factor-1	3458	3659	Gene	Gene	attenuation|amod|START_ENTITY mediator|nmod|attenuation mediator|nsubj|END_ENTITY	Interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression .
10210769	0	interferon-gamma	35,51	Interleukin-10	0,14	interferon-gamma	Interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interleukin-10 in combination with interferon-gamma and tumor_necrosis_factor-alpha enhances in vitro production of nitric_oxide by murine resident paritoneal macrophage .
11172617	0	interferon-gamma	50,66	Interleukin-10	0,14	interferon-gamma	Interleukin-10	3458	3586	Gene	Gene	effects|nmod|START_ENTITY relieves|dobj|effects relieves|nsubj|END_ENTITY	Interleukin-10 relieves the inhibitory effects of interferon-gamma on normal human lung fibroblasts .
1371674	0	interferon-gamma	74,90	Interleukin-10	0,14	interferon-gamma	Interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-10 -LRB- IL-10 -RRB- inhibits the induction of nitric_oxide synthase by interferon-gamma in murine macrophages .
8181527	0	interferon-gamma	24,40	Interleukin-10	0,14	interferon-gamma	Interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|compound|START_ENTITY controls|dobj|production controls|nsubj|END_ENTITY	Interleukin-10 controls interferon-gamma and tumor_necrosis_factor production during experimental endotoxemia .
10233697	0	interferon-gamma	57,73	Interleukin-15	0,14	interferon-gamma	Interleukin-15	3458	3600	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin-15 differentially enhances the expression of interferon-gamma and interleukin-4 in activated human -LRB- CD4 + -RRB- T lymphocytes .
10486154	0	interferon-gamma	23,39	Interleukin-18	0,14	interferon-gamma	Interleukin-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-18 induces interferon-gamma production through NF-kappaB and NFAT activation in murine T helper type 1 cells .
11834721	0	interferon-gamma	89,105	Interleukin-18	0,14	interferon-gamma	Interleukin-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY enhances|nmod|release enhances|nsubj|END_ENTITY	Interleukin-18 enhances atherosclerosis in apolipoprotein_E -LRB- - / - -RRB- mice through release of interferon-gamma .
14640238	0	interferon-gamma	74,90	Interleukin-18	0,14	interferon-gamma	Interleukin-18	3458	3606	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Interleukin-18 , interleukin-18_binding_protein and impaired production of interferon-gamma in chronic renal_failure .
15162834	0	interferon-gamma	42,58	Interleukin-18	0,14	interferon-gamma	Interleukin-18	3458	3606	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interleukin-18 enhances the production of interferon-gamma -LRB- IFN-gamma -RRB- by allergen-specific and unspecific stimulated cord blood mononuclear cells .
9815245	0	interferon-gamma	51,67	Interleukin-18	0,14	interferon-gamma	Interleukin-18	3458	3606	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures .
7797254	0	interferon-gamma	57,73	Interleukin-2	0,13	interferon-gamma	Interleukin-2	3458	3558	Gene	Gene	expression|amod|START_ENTITY activation|nmod|expression step|nmod|activation induces|dobj|step induces|nsubj|END_ENTITY	Interleukin-2 induces an early step in the activation of interferon-gamma gene expression .
8382095	0	interferon-gamma	15,31	Interleukin-2	0,13	interferon-gamma	Interleukin-2	3458	3558	Gene	Gene	lavage|nsubj|START_ENTITY lavage|advmod|END_ENTITY	Interleukin-2 , interferon-gamma and natural killer cell activity in bronchoalveolar lavage fluid from marrow transplant recipients with cytomegalovirus_pneumonia .
9203963	0	interferon-gamma	96,112	Interleukin-7	0,13	interferon-gamma	Interleukin-7	15978(Tax:10090)	16196(Tax:10090)	Gene	Gene	production|amod|START_ENTITY decrease|nmod|production associated|nmod|decrease associated|nsubjpass|END_ENTITY	Interleukin-7 in the skin of Schistosoma_mansoni-infected mice is associated with a decrease in interferon-gamma production and leads to an aggravation of the disease .
3097133	0	interferon-gamma	27,43	Interleukin_2	0,13	interferon-gamma	Interleukin 2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY induction|nmod|synthesis induction|amod|END_ENTITY	Interleukin_2 induction of interferon-gamma mRNA synthesis .
3121725	0	interferon-gamma	43,59	Interleukin_2	0,13	interferon-gamma	Interleukin 2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|dobj|production	Interleukin_2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways .
1899386	0	interferon-gamma	82,98	Interleukin_4	0,13	interferon-gamma	Interleukin 4	3458	3565	Gene	Gene	synergy|nmod|START_ENTITY induces|parataxis|synergy induces|nsubj|END_ENTITY	Interleukin_4 induces interleukin_6 production by endothelial cells : synergy with interferon-gamma .
1900240	1	interferon-gamma	93,109	Interleukin_4	63,76	interferon-gamma	Interleukin 4	15978(Tax:10090)	16189(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Interleukin_4 synergizes with interferon-gamma to activate murine macrophages for killing of Leishmania_major_amastigotes .
2475518	0	interferon-gamma	11,27	LFA-1	105,110	interferon-gamma	LFA-1	3458	3683	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of interferon-gamma -LRB- IFN-gamma -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on the expression of LFA-1 in the moderate phenotype of leukocyte_adhesion_deficiency -LRB- LAD -RRB- .
9627099	0	interferon-gamma	36,52	LHRH	14,18	interferon-gamma	LHRH	3458	2796	Gene	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	The effect of LHRH and TRH on human interferon-gamma production in vivo and in vitro .
10403908	0	interferon-gamma	61,77	MHC	23,26	interferon-gamma	MHC	3458	3133	Gene	Gene	response|nmod|START_ENTITY molecules|nmod|response molecules|compound|END_ENTITY	Impaired expression of MHC class II molecules in response to interferon-gamma -LRB- IFN-gamma -RRB- on human thymoma neoplastic epithelial cells .
3106398	0	interferon-gamma	152,168	MHC	22,25	interferon-gamma	MHC	3458	3133	Gene	Gene	expression|nmod|START_ENTITY enhancement|nmod|expression induction|dep|enhancement induction|nmod|_ _|compound|END_ENTITY	Separate induction of MHC and thyroid_microsomal_antigen _ -LRB- McAg -RRB- expression on thyroid cell monolayers : enhancement of lectin-induced McAg expression by interferon-gamma .
3135484	0	interferon-gamma	65,81	MHC	14,17	interferon-gamma	MHC	25712(Tax:10116)	3133	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of MHC protein expression in pancreatic beta-cells by interferon-gamma and tumor_necrosis_factor-alpha .
9130458	0	interferon-gamma	63,79	MMP-2	14,19	interferon-gamma	MMP-2	3458	4313	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|END_ENTITY	Modulation of MMP-2 -LRB- gelatinase A -RRB- and MMP-9 -LRB- gelatinase B -RRB- by interferon-gamma in a human salivary gland cell line .
12210742	0	interferon-gamma	97,113	MUC1	27,31	interferon-gamma	MUC1	3458	4582	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|expression expression|compound|END_ENTITY	Synergistic stimulation of MUC1 expression in normal breast epithelia and breast_cancer cells by interferon-gamma and tumor_necrosis_factor-alpha .
7842630	0	interferon-gamma	10,26	MUC1	44,48	interferon-gamma	MUC1	3458	4582	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian_carcinoma cell lines .
16007204	0	interferon-gamma	48,64	MUC4	29,33	interferon-gamma	MUC4	3458	4585	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic_acid in human pancreatic_tumour cells involves a reprogramming of signalling pathways .
9058317	0	interferon-gamma	55,71	Platelet-activating_factor	0,26	interferon-gamma	Platelet-activating factor	3458	9768	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Platelet-activating_factor and the production of human interferon-gamma .
12788307	0	interferon-gamma	33,49	Prolactin	0,9	interferon-gamma	Prolactin	3458	5617	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Prolactin enhances production of interferon-gamma , interleukin-12 , and interleukin-10 , but not of tumor_necrosis_factor-alpha , in a stimulus-specific manner .
10224471	0	interferon-gamma	11,27	RANTES	78,84	interferon-gamma	RANTES	3458	6352	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interferon-gamma on mobilization and release of eosinophil-derived RANTES .
10381494	0	interferon-gamma	67,83	RANTES	45,51	interferon-gamma	RANTES	3458	6352	Gene	Gene	stored|nmod|START_ENTITY stored|dobj|END_ENTITY	Rapid mobilization of intracellularly stored RANTES in response to interferon-gamma in human eosinophils .
7687472	0	interferon-gamma	33,49	Rapamycin	0,9	interferon-gamma	Rapamycin	15978(Tax:10090)	74370(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T_cell_lymphoma .
15181474	0	interferon-gamma	45,61	Retinoic_acid-inducible_gene-I	0,30	interferon-gamma	Retinoic acid-inducible gene-I	3458	23586	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Retinoic_acid-inducible_gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells .
18258269	0	interferon-gamma	45,61	Retinoic_acid-inducible_gene-I	0,30	interferon-gamma	Retinoic acid-inducible gene-I	3458	23586	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Retinoic_acid-inducible_gene-I is induced by interferon-gamma and regulates CXCL11 expression in HeLa cells .
16436660	0	interferon-gamma	44,60	SEMA6A	23,29	interferon-gamma	SEMA6A	3458	57556	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations .
10506184	0	interferon-gamma	46,62	STAT1	10,15	interferon-gamma	STAT1	25712(Tax:10116)	25124(Tax:10116)	Gene	Gene	priming|amod|START_ENTITY associated|nmod|priming associated|nsubjpass|activation activation|compound|END_ENTITY	Prolonged STAT1 activation is associated with interferon-gamma priming for interleukin-1-induced inducible_nitric-oxide_synthase expression by islets of Langerhans .
11159690	0	interferon-gamma	21,37	STAT1	92,97	interferon-gamma	STAT1	15978(Tax:10090)	20846(Tax:10090)	Gene	Gene	START_ENTITY|nmod|macrophages macrophages|amod|due due|xcomp|tyrosine tyrosine|dobj|nitration nitration|nmod|END_ENTITY	Impaired response to interferon-gamma in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric_oxide .
11756175	0	interferon-gamma	146,162	STAT1	114,119	interferon-gamma	STAT1	3458	6772	Gene	Gene	secretion|nmod|START_ENTITY induces|nmod|secretion induces|nmod|activation activation|nmod|END_ENTITY	Human_T-cell_leukemia_virus_type_2 induces survival and proliferation of CD34 -LRB- + -RRB- TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte_macrophage-colony-stimulating_factor .
15284232	0	interferon-gamma	57,73	STAT1	26,31	interferon-gamma	STAT1	15978(Tax:10090)	20846(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Alternative activation of STAT1 and STAT3 in response to interferon-gamma .
17116388	0	interferon-gamma	22,38	STAT1	102,107	interferon-gamma	STAT1	25712(Tax:10116)	25124(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expression .
17201122	0	interferon-gamma	33,49	STAT1	73,78	interferon-gamma	STAT1	3458	6772	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death .
19018808	0	interferon-gamma	23,39	STAT1	65,70	interferon-gamma	STAT1	15978(Tax:10090)	20846(Tax:10090)	Gene	Gene	action|amod|START_ENTITY action|nmod|modulation modulation|nmod|END_ENTITY	Pravastatin attenuates interferon-gamma action via modulation of STAT1 to prevent aortic_atherosclerosis in apolipoprotein_E-knockout mice .
19781632	0	interferon-gamma	26,42	STAT1	121,126	interferon-gamma	STAT1	3458	6772	Gene	Gene	signalling|amod|START_ENTITY modelling|nmod|signalling reflects|nsubj|modelling reflects|dobj|dynamics dynamics|nmod|activity activity|compound|END_ENTITY	Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activity .
23942267	0	interferon-gamma	25,41	STAT1	93,98	interferon-gamma	STAT1	3458	6772	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|nmod|END_ENTITY	Sodium_butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 in nasopharyngeal_carcinoma cells .
10080544	0	interferon-gamma	40,56	STAT3	31,36	interferon-gamma	STAT3	3458	6774	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils .
10652022	0	interferon-gamma	19,35	Stat1	66,71	interferon-gamma	Stat1	25712(Tax:10116)	25124(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|acl|signaling signaling|nmod|transfer transfer|nmod|mutant mutant|compound|END_ENTITY	Down-regulation of interferon-gamma signaling by gene transfer of Stat1 mutant in mesangial cells .
16467883	0	interferon-gamma	45,61	Stat1	32,37	interferon-gamma	Stat1	3458	6772	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Modulation of the activation of Stat1 by the interferon-gamma receptor complex .
21321110	0	interferon-gamma	66,82	Stat1	42,47	interferon-gamma	Stat1	3458	6772	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|activation activation|nmod|END_ENTITY	Up-regulation and sustained activation of Stat1 are essential for interferon-gamma -LRB- IFN-gamma -RRB- - induced dual_oxidase_2 -LRB- Duox2 -RRB- and dual_oxidase_A2 -LRB- DuoxA2 -RRB- expression in human pancreatic_cancer cell lines .
24464587	0	interferon-gamma	52,68	Stat1	128,133	interferon-gamma	Stat1	15978(Tax:10090)	20846(Tax:10090)	Gene	Gene	promotion|nmod|START_ENTITY mechanism|nmod|promotion /|nsubj|mechanism /|dobj|END_ENTITY	A novel mechanism of skin_tumor promotion involving interferon-gamma -LRB- IFNy -RRB- / signal_transducer_and_activator_of_transcription-1 -LRB- Stat1 -RRB- signaling .
9389691	0	interferon-gamma	118,134	Stat1	161,166	interferon-gamma	Stat1	3458	6772	Gene	Gene	effects|nmod|START_ENTITY predominance|nmod|effects results|nmod|predominance Inhibition|nmod|results Inhibition|amod|due due|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Inhibition of interferon_regulatory_factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3 .
9491997	0	interferon-gamma	55,71	Stat1	113,118	interferon-gamma	Stat1	3458	6772	Gene	Gene	CIITA|nmod|START_ENTITY Activation|nmod|CIITA requires|nsubj|Activation requires|dobj|interaction interaction|nmod|END_ENTITY	Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1 .
14511121	0	interferon-gamma	16,32	Stat3	33,38	interferon-gamma	Stat3	3458	6774	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines .
15649407	0	interferon-gamma	41,57	Stat3	97,102	interferon-gamma	Stat3	15978(Tax:10090)	20848(Tax:10090)	Gene	Gene	SOCS-3|nmod|START_ENTITY induction|nmod|SOCS-3 mediated|nsubjpass|induction mediated|nmod|activation activation|nmod|END_ENTITY	Stat1-independent induction of SOCS-3 by interferon-gamma is mediated by sustained activation of Stat3 in mouse embryonic fibroblasts .
16332928	0	interferon-gamma	62,78	Stat3	20,25	interferon-gamma	Stat3	3458	6774	Gene	Gene	inhibition|amod|START_ENTITY mediating|dobj|inhibition activation|acl|mediating activation|dep|Distinctive Distinctive|dobj|role role|nmod|END_ENTITY	Distinctive role of Stat3 and Erk-1 / 2 activation in mediating interferon-gamma inhibition of TGF-beta1 action .
7488223	0	interferon-gamma	87,103	Stat3	66,71	interferon-gamma	Stat3	3458	6774	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- expression by interferon-gamma and interleukin-6 in hepatoma cells .
2449707	0	interferon-gamma	21,37	Substance_P	0,11	interferon-gamma	Substance P	3458	6863	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Substance_P enhances interferon-gamma production by human peripheral blood mononuclear cells .
11752460	0	interferon-gamma	28,44	T-bet	0,5	interferon-gamma	T-bet	15978(Tax:10090)	57765(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells .
19123327	0	interferon-gamma	57,73	T-bet	115,120	interferon-gamma	T-bet	3458	30009	Gene	Gene	factor|amod|START_ENTITY expressions|nmod|factor procyanidins|nmod|expressions effect|nmod|procyanidins END_ENTITY|nsubj|effect	-LSB- Regulatory effect of procyanidins on the expressions of interferon-gamma , interleukin-12 and transcription factor T-bet mRNA in peripheral blood mononuclear cell of patients with alopecia_areata -RSB- .
19186970	0	interferon-gamma	10,26	T-bet	52,57	interferon-gamma	T-bet	3458	30009	Gene	Gene	factor|compound|START_ENTITY Levels|nmod|factor END_ENTITY|nsubj|Levels	Levels of interferon-gamma and transcription factor T-bet in progressive periodontal lesions in patients with chronic_periodontitis .
19757302	0	interferon-gamma	104,120	T-bet	28,33	interferon-gamma	T-bet	3458	30009	Gene	Gene	production|amod|START_ENTITY expression|nmod|production expression|nsubj|T-box-expressed-in-T-cells T-box-expressed-in-T-cells|appos|END_ENTITY	T-box-expressed-in-T-cells -LRB- T-bet -RRB- expression by the tumor cells of hairy-cell_leukemia correlates with interferon-gamma production .
10193415	0	interferon-gamma	52,68	TGF-beta	201,209	interferon-gamma	TGF-beta	15978(Tax:10090)	21803(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The modulating effects of proinflammatory cytokines interferon-gamma -LRB- IFN-gamma -RRB- and tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , and immunoregulating cytokines IL-10 and transforming growth factor-beta -LRB- TGF-beta -RRB- , on anti-microbial activity of murine peritoneal macrophages against Mycobacterium_avium-intracellulare complex .
7955537	0	interferon-gamma	28,44	TGF-beta	88,96	interferon-gamma	TGF-beta	25712(Tax:10116)	59086(Tax:10116)	Gene	Gene	IL-4|amod|START_ENTITY factor-beta|compound|IL-4 factor-beta|appos|END_ENTITY	Cellular mRNA expression of interferon-gamma , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- by rat mononuclear cells stimulated with peripheral nerve myelin antigens in experimental_allergic_neuritis .
9099937	0	interferon-gamma	28,44	TGF-beta	100,108	interferon-gamma	TGF-beta	25712(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cellular mRNA expression of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming growth factor-beta -LRB- TGF-beta -RRB- in rats nasally tolerized against experimental autoimmune_myasthenia_gravis -LRB- EAMG -RRB- .
1587306	0	interferon-gamma	15,31	THP-1	78,83	interferon-gamma	THP-1	3458	2736	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Iron modulates interferon-gamma effects in the human myelomonocytic cell line THP-1 .
1572101	0	interferon-gamma	10,26	TNF	156,159	interferon-gamma	TNF	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|acl|priming priming|xcomp|tumouricidal tumouricidal|nmod|cisplatin cisplatin|appos|END_ENTITY	Effect of interferon-gamma priming on the activation of murine peritoneal macrophages to tumouricidal state by cisplatin , IL-1 , and tumour_necrosis_factor -LRB- TNF -RRB- : production of IL-1_and_TNF .
2495751	0	interferon-gamma	24,40	TNF	0,3	interferon-gamma	TNF	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	TNF in combination with interferon-gamma is cytotoxic to normal , untransformed mouse and rat embryo fibroblast-like cells .
3117378	0	interferon-gamma	54,70	TNF	109,112	interferon-gamma	TNF	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY Regulation|nmod|expression enhances|nsubj|Regulation enhances|dobj|accumulation accumulation|nmod|mRNA mRNA|nmod|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
3117378	0	interferon-gamma	54,70	TNF	37,40	interferon-gamma	TNF	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|appos|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
12563732	0	interferon-gamma	66,82	TNF-alpha	97,106	interferon-gamma	TNF-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|advcl|-RSB- -RSB-|compound|END_ENTITY	-LSB- Anti-Toxoplasma effect of activated mouse macrophages induced by interferon-gamma combined with TNF-alpha -RSB- .
1532988	0	interferon-gamma	158,174	TNF-alpha	79,88	interferon-gamma	TNF-alpha	3458	7124	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Different molecular mechanisms lead to same endpoints with different function : TNF-alpha induces non-functional CSF-1 receptors on HL-60 cells in contrast to interferon-gamma .
15806975	0	interferon-gamma	50,66	TNF-alpha	109,118	interferon-gamma	TNF-alpha	3458	7124	Gene	Gene	START_ENTITY|appos|tumor_necrosis_factor-alpha tumor_necrosis_factor-alpha|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
18208824	0	interferon-gamma	165,181	TNF-alpha	110,119	interferon-gamma	TNF-alpha	3458	7124	Gene	Gene	release|amod|START_ENTITY using|dobj|release blocking|advcl|using END_ENTITY|acl|blocking	Evaluation of latent_tuberculosis_infection in patients with inflammatory arthropathies before treatment with TNF-alpha blocking drugs using a novel flow-cytometric interferon-gamma release assay .
8038591	0	interferon-gamma	88,104	TNF-alpha	76,85	interferon-gamma	TNF-alpha	3458	7124	Gene	Gene	factor-alpha|appos|START_ENTITY factor-alpha|appos|END_ENTITY	Isolated perfusion of the limb with high-dose tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- , interferon-gamma -LRB- IFN-gamma -RRB- and melphalan for melanoma stage III .
9472684	0	interferon-gamma	101,117	TNF-alpha	83,92	interferon-gamma	TNF-alpha	3458	7124	Gene	Gene	Apoptosis|amod|START_ENTITY Apoptosis|nmod|and/or and/or|appos|END_ENTITY	Apoptosis of colorectal_adenocarcinoma -LRB- COLO 201 -RRB- by tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- and/or interferon-gamma -LRB- IFN-gamma -RRB- , resulting from down-modulation of Bcl-2 expression .
14730360	0	interferon-gamma	48,64	TRADD	0,5	interferon-gamma	TRADD	3458	8717	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRADD interacts with STAT1-alpha and influences interferon-gamma signaling .
11897670	0	interferon-gamma	34,50	Th1	27,30	interferon-gamma	Th1	15978(Tax:10090)	57314(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Immune deviation away from Th1 in interferon-gamma knockout mice does not enhance TSH_receptor antibody production after naked DNA vaccination .
12525871	0	interferon-gamma	97,113	Transforming_growth_factor-beta	0,31	interferon-gamma	Transforming growth factor-beta	3458	7040	Gene	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta released by PPD-presenting malignant_mesothelioma cells inhibits interferon-gamma synthesis by an anti-PPD CD4 + T-cell clone .
15852008	0	interferon-gamma	116,132	Transforming_growth_factor-beta	0,31	interferon-gamma	Transforming growth factor-beta	3458	7040	Gene	Gene	regulation|nmod|START_ENTITY development|nmod|regulation helper|dobj|development helper|nsubj|controls controls|amod|END_ENTITY	Transforming_growth_factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma .
9420430	0	interferon-gamma	41,57	Transforming_growth_factor-beta	0,31	interferon-gamma	Transforming growth factor-beta	3458	7040	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits interferon-gamma secretion by lymphokine-activated killer cells stimulated with tumor cells .
10842245	0	interferon-gamma	109,125	TrkA	87,91	interferon-gamma	TrkA	3458	4914	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|compound|END_ENTITY	Neuronal differentiation in human neuroblastoma cells by nerve_growth_factor following TrkA up-regulation by interferon-gamma .
3097823	0	interferon-gamma	67,83	Tumor_necrosis_factor	0,21	interferon-gamma	Tumor necrosis factor	3458	7124	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Tumor_necrosis_factor reduces c-myc expression and cooperates with interferon-gamma in HeLa cells .
2113475	0	interferon-gamma	48,64	Tumor_necrosis_factor-alpha	0,27	interferon-gamma	Tumor necrosis factor-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Tumor_necrosis_factor-alpha in combination with interferon-gamma , but not with interleukin_4 activates murine macrophages for elimination of Leishmania_major amastigotes .
7489766	0	interferon-gamma	118,134	Tumor_necrosis_factor-alpha	0,27	interferon-gamma	Tumor necrosis factor-alpha	3458	7124	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|induction induction|amod|END_ENTITY	Tumor_necrosis_factor-alpha induction of major histocompatibility complex class II antigen expression is inhibited by interferon-gamma in a monocytic cell line .
15792835	0	interferon-gamma	59,75	aminopeptidase_N	14,30	interferon-gamma	aminopeptidase N	3458	290	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of aminopeptidase_N -LRB- EC 3.4.11.2 ; APN ; CD13 -RRB- by interferon-gamma on the HL-60 cell line .
16949687	0	interferon-gamma	66,82	angiotensinogen	22,37	interferon-gamma	angiotensinogen	3458	183	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Upregulation of human angiotensinogen -LRB- AGT -RRB- gene transcription by interferon-gamma : involvement of the STAT1-binding motif in the AGT promoter .
2977292	0	interferon-gamma	40,56	beta-endorphin	22,36	interferon-gamma	beta-endorphin	3458	5443	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Modulatory effects of beta-endorphin on interferon-gamma production by cultured peripheral blood mononuclear cells : heterogeneity among donors and the influence of culture medium .
19761720	0	interferon-gamma	33,49	beta2-microglobulin	83,102	interferon-gamma	beta2-microglobulin	3458	567	Gene	Gene	production|amod|START_ENTITY production|dep|role role|nmod|END_ENTITY	Low-flux hemodialysis suppresses interferon-gamma production : the possible role of beta2-microglobulin .
7759501	0	interferon-gamma	43,59	c-Jun	121,126	interferon-gamma	c-Jun	3458	3725	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun .
7545471	0	interferon-gamma	55,71	colony-stimulating_factor-1	102,129	interferon-gamma	colony-stimulating factor-1	3458	1435	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|END_ENTITY	Blockage of the early events of mitogenic signaling by interferon-gamma in macrophages in response to colony-stimulating_factor-1 .
15465602	0	interferon-gamma	24,40	cyclooxygenase-2	62,78	interferon-gamma	cyclooxygenase-2	3458	5743	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	Differential effects of interferon-gamma on the expression of cyclooxygenase-2 in high-grade human gliomas versus primary astrocytes .
14566010	0	interferon-gamma	56,72	cytochrome_P450_2E1	15,34	interferon-gamma	cytochrome P450 2E1	3458	1571	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Suppression of cytochrome_P450_2E1 promoter activity by interferon-gamma and loss of response due to the -71 G > T nucleotide polymorphism of the CYP2E1 * 7B allele .
14511121	0	interferon-gamma	16,32	gp130	85,90	interferon-gamma	gp130	3458	3572	Gene	Gene	response|amod|START_ENTITY Induction|nmod|response Induction|nmod|cytokines cytokines|amod|END_ENTITY	Induction of an interferon-gamma Stat3 response in nerve cells by pre-treatment with gp130 cytokines .
6425204	0	interferon-gamma	88,104	granulocyte-macrophage_colony_stimulating_factor	38,86	interferon-gamma	granulocyte-macrophage colony stimulating factor	3458	1437	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Production of five human lymphokines -LRB- granulocyte-macrophage_colony_stimulating_factor , interferon-gamma , interleukin_2 , macrophage cytotoxicity factor and macrophage_migration_inhibitory_factor -RRB- from Con A stimulated lymphocyte cultures in bioreactors .
12198566	0	interferon-gamma	18,34	growth_hormone	45,59	interferon-gamma	growth hormone	25712(Tax:10116)	81668(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY mechanism|nmod|increases -LSB-|dobj|mechanism -LSB-|dep|END_ENTITY	-LSB- The mechanism of interferon-gamma increases growth_hormone expression in rat pituitary GH -LRB- 3 -RRB- cells -RSB- .
15003714	0	interferon-gamma	83,99	growth_hormone-releasing_hormone	10,42	interferon-gamma	growth hormone-releasing hormone	3458	2691	Gene	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of growth_hormone-releasing_hormone -LRB- GHRH -RRB- and GHRH antagonist -LRB- MZ-4-71 -RRB- on interferon-gamma secretion from human peripheral blood mononuclear cells in vitro .
10349844	0	interferon-gamma	51,67	heme_oxygenase-1	15,31	interferon-gamma	heme oxygenase-1	3458	3162	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of heme_oxygenase-1 mRNA expression by interferon-gamma in human glioblastoma cells .
15233805	0	interferon-gamma	47,63	heme_oxygenase-1	14,30	interferon-gamma	heme oxygenase-1	3458	3162	Gene	Gene	repressed|nmod|START_ENTITY repressed|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of heme_oxygenase-1 is repressed by interferon-gamma and induced by hypoxia in human retinal pigment epithelial cells .
15541342	0	interferon-gamma	116,132	hepatocyte_growth_factor	14,38	interferon-gamma	hepatocyte growth factor	3458	3082	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of hepatocyte_growth_factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma .
9018086	0	interferon-gamma	26,42	iNOS	13,17	interferon-gamma	iNOS	3458	4843	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Induction of iNOS mRNA by interferon-gamma in epithelial cells is associated with growth_arrest and differentiation .
12364868	0	interferon-gamma	86,102	intercellular_adhesion_molecule-1	23,56	interferon-gamma	intercellular adhesion molecule-1	3458	3383	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of histamine on intercellular_adhesion_molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18 .
2530332	0	interferon-gamma	154,170	interferon-alpha_2a	44,63	interferon-gamma	interferon-alpha 2a	3458	3440	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The synergistic effect of human recombinant interferon-alpha_2a in combination with interferon-gamma and the induction of interferon-alpha_2a receptor by interferon-gamma .
2530332	0	interferon-gamma	84,100	interferon-alpha_2a	44,63	interferon-gamma	interferon-alpha 2a	3458	3440	Gene	Gene	combination|nmod|START_ENTITY effect|nmod|combination effect|nmod|END_ENTITY	The synergistic effect of human recombinant interferon-alpha_2a in combination with interferon-gamma and the induction of interferon-alpha_2a receptor by interferon-gamma .
1646275	0	interferon-gamma	139,155	interferon-gamma	82,98	interferon-gamma	interferon-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Acquired immunity of A/J mice to mouse hepatitis virus 3 infection : dependence on interferon-gamma synthesis and macrophage sensitivity to interferon-gamma .
1646275	0	interferon-gamma	82,98	interferon-gamma	139,155	interferon-gamma	interferon-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Acquired immunity of A/J mice to mouse hepatitis virus 3 infection : dependence on interferon-gamma synthesis and macrophage sensitivity to interferon-gamma .
2502555	0	interferon-gamma	146,162	interferon-gamma	62,78	interferon-gamma	interferon-gamma	3458	3458	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of tumor_necrosis_factor-alpha on the modulation by interferon-gamma of HLA class II molecules in human thyroid cells and its effect on interferon-gamma binding .
2502555	0	interferon-gamma	62,78	interferon-gamma	146,162	interferon-gamma	interferon-gamma	3458	3458	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of tumor_necrosis_factor-alpha on the modulation by interferon-gamma of HLA class II molecules in human thyroid cells and its effect on interferon-gamma binding .
2530332	0	interferon-gamma	154,170	interferon-gamma	84,100	interferon-gamma	interferon-gamma	3458	3458	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|combination combination|nmod|END_ENTITY	The synergistic effect of human recombinant interferon-alpha_2a in combination with interferon-gamma and the induction of interferon-alpha_2a receptor by interferon-gamma .
2530332	0	interferon-gamma	84,100	interferon-gamma	154,170	interferon-gamma	interferon-gamma	3458	3458	Gene	Gene	combination|nmod|START_ENTITY effect|nmod|combination effect|nmod|END_ENTITY	The synergistic effect of human recombinant interferon-alpha_2a in combination with interferon-gamma and the induction of interferon-alpha_2a receptor by interferon-gamma .
8566077	0	interferon-gamma	31,47	interferon-gamma	51,67	interferon-gamma	interferon-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man .
8566077	0	interferon-gamma	51,67	interferon-gamma	31,47	interferon-gamma	interferon-gamma	15978(Tax:10090)	15978(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Specific expression of surface interferon-gamma on interferon-gamma producing T cells from mouse and man .
9806040	0	interferon-gamma	23,39	interferon-gamma_receptor_1	98,125	interferon-gamma	interferon-gamma receptor 1	3458	3459	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Abnormal regulation of interferon-gamma , interleukin-12 , and tumor_necrosis_factor-alpha in human interferon-gamma_receptor_1 deficiency .
14993214	0	interferon-gamma	40,56	interferon_regulatory_factor-1	141,171	interferon-gamma	interferon regulatory factor-1	3458	3659	Gene	Gene	caspase-8|nmod|START_ENTITY cells|amod|caspase-8 up-regulation|nmod|cells requires|nsubj|up-regulation requires|xcomp|END_ENTITY	The up-regulation of human caspase-8 by interferon-gamma in breast_tumor cells requires the induction and action of the transcription factor interferon_regulatory_factor-1 .
7499267	0	interferon-gamma	46,62	interferon_regulatory_factor-1	143,173	interferon-gamma	interferon regulatory factor-1	3458	3659	Gene	Gene	Triggering|nmod|START_ENTITY involves|csubj|Triggering involves|dobj|cooperation cooperation|nmod|END_ENTITY	Triggering of the human interleukin-6 gene by interferon-gamma and tumor_necrosis_factor-alpha in monocytic cells involves cooperation between interferon_regulatory_factor-1 , NF kappa B , and Sp1 transcription factors .
7579440	0	interferon-gamma	28,44	interferon_regulatory_factor-1	75,105	interferon-gamma	interferon regulatory factor-1	3458	3659	Gene	Gene	inhibition|nmod|START_ENTITY mediated|nsubj|inhibition mediated|advcl|END_ENTITY	Hematopoietic inhibition by interferon-gamma is partially mediated through interferon_regulatory_factor-1 .
8910434	0	interferon-gamma	96,112	interferon_regulatory_factor-1	8,38	interferon-gamma	interferon regulatory factor-1	3458	3659	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of interferon_regulatory_factor-1 in the induction of biliary_glycoprotein -LRB- cell CAM-1 -RRB- by interferon-gamma .
9389691	0	interferon-gamma	118,134	interferon_regulatory_factor-1	14,44	interferon-gamma	interferon regulatory factor-1	3458	3659	Gene	Gene	effects|nmod|START_ENTITY predominance|nmod|effects results|nmod|predominance results|amod|END_ENTITY	Inhibition of interferon_regulatory_factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3 .
15541342	0	interferon-gamma	116,132	interleukin-1	80,93	interferon-gamma	interleukin-1	3458	3552	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Inhibition of hepatocyte_growth_factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma .
10088138	0	interferon-gamma	68,84	interleukin-10	104,118	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|secretion secretion|amod|END_ENTITY	Negative immunoregulatory effects of antidepressants : inhibition of interferon-gamma and stimulation of interleukin-10 secretion .
10417669	0	interferon-gamma	72,88	interleukin-10	112,126	interferon-gamma	interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nmod|upregulation upregulation|nmod|END_ENTITY	Salivary gland extract from Ixodes ricinus ticks inhibits production of interferon-gamma by the upregulation of interleukin-10 .
12168924	0	interferon-gamma	54,70	interleukin-10	17,31	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	production|amod|START_ENTITY influence|nmod|production influence|acl|END_ENTITY	The influence of interleukin-10 and interleukin-18 on interferon-gamma production by peritoneal exudate cells in patients with gastric_carcinoma .
15809204	0	interferon-gamma	7,23	interleukin-10	25,39	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	START_ENTITY|appos|markers markers|amod|END_ENTITY	Plasma interferon-gamma , interleukin-10 and soluble markers of immune activation in infants with primary adenovirus -LRB- ADV -RRB- and respiratory_syncytial_virus _ -LRB- RSV -RRB- _ infection .
15829292	0	interferon-gamma	29,45	interleukin-10	76,90	interferon-gamma	interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppression|nmod|production suppression|nmod|production production|amod|END_ENTITY	Tumor-induced suppression of interferon-gamma production and enhancement of interleukin-10 production by natural killer -LRB- NK -RRB- cells : paralleled to CD4 + T cells .
17005337	0	interferon-gamma	148,164	interleukin-10	111,125	interferon-gamma	interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Characterization of Th1 activation by Bartonella_henselae stimulation in BALB/c mice : Inhibitory activities of interleukin-10 for the production of interferon-gamma in spleen cells .
17509455	0	interferon-gamma	17,33	interleukin-10	35,49	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Polymorphisms of interferon-gamma , interleukin-10 , and interleukin-12 genes in myasthenia_gravis .
19124156	0	interferon-gamma	13,29	interleukin-10	58,72	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	Mechanism|nmod|START_ENTITY mediated|nsubj|Mechanism mediated|dobj|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression .
20404426	0	interferon-gamma	31,47	interleukin-10	15,29	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	transforming_growth_factor-beta|amod|START_ENTITY transforming_growth_factor-beta|amod|END_ENTITY	Association of interleukin-10 , interferon-gamma , transforming_growth_factor-beta , and tumor_necrosis_factor-alpha gene polymorphisms with long-term kidney allograft survival .
7688311	0	interferon-gamma	51,67	interleukin-10	115,129	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	production|nmod|START_ENTITY Induction|nmod|production enhanced|nsubjpass|Induction enhanced|advcl|END_ENTITY	Induction of macrophage nitric_oxide production by interferon-gamma and tumor_necrosis_factor-alpha is enhanced by interleukin-10 .
8611751	0	interferon-gamma	65,81	interleukin-10	106,120	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|advcl|producing producing|xcomp|END_ENTITY	Alpha s1-casein-specific CD8 + T cell clone that inhibits its own interferon-gamma production by producing interleukin-10 .
9003248	0	interferon-gamma	93,109	interleukin-10	155,169	interferon-gamma	interleukin-10	15978(Tax:10090)	16153(Tax:10090)	Gene	Gene	START_ENTITY|nmod|agents agents|amod|END_ENTITY	Analysis of B7-1_and_B7-2 costimulatory ligands in cultured mouse microglia : upregulation by interferon-gamma and lipopolysaccharide and downregulation by interleukin-10 , prostaglandin_E2 and cyclic_AMP-elevating agents .
9018762	0	interferon-gamma	23,39	interleukin-10	41,55	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Expression of mRNA for interferon-gamma , interleukin-10 , and interleukin-12 -LRB- p40 -RRB- in normal gastric_mucosa_and_in_mucosa_infected with Helicobacter_pylori .
9041358	0	interferon-gamma	169,185	interleukin-10	97,111	interferon-gamma	interleukin-10	3458	3586	Gene	Gene	induce|dobj|START_ENTITY induce|advcl|induce induce|dobj|mRNA mRNA|nmod|END_ENTITY	Leishmania aethiopica derived from diffuse leishmaniasis patients preferentially induce mRNA for interleukin-10 while those from localized leishmaniasis patients induce interferon-gamma .
9713135	0	interferon-gamma	34,50	interleukin-10_and_tumor_necrosis_factor-alpha	52,98	interferon-gamma	interleukin-10 and tumor necrosis factor-alpha	3458	3586;7124	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Presence of circulating levels of interferon-gamma , interleukin-10_and_tumor_necrosis_factor-alpha in patients with visceral_leishmaniasis .
10942393	0	interferon-gamma	138,154	interleukin-18	20,34	interferon-gamma	interleukin-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|compound|START_ENTITY role|nmod|production response|dep|role induces|dobj|response induces|nsubj|Coadministration Coadministration|acl|END_ENTITY	Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice : critical role of natural killer cell interferon-gamma production and STAT-mediated signal transduction .
11061569	0	interferon-gamma	32,48	interleukin-18	81,95	interferon-gamma	interleukin-18	3458	3606	Gene	Gene	production|amod|START_ENTITY inhibit|dobj|production inhibit|nmod|downregulation downregulation|nmod|reactions reactions|amod|END_ENTITY	Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions .
11474118	0	interferon-gamma	8,24	interleukin-18	60,74	interferon-gamma	interleukin-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY Lack|nmod|production wound|nsubj|Lack wound|nmod|presence presence|nmod|END_ENTITY	Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing .
12364868	0	interferon-gamma	86,102	interleukin-18	167,181	interferon-gamma	interleukin-18	3458	3606	Gene	Gene	Effect|nmod|START_ENTITY Effect|acl|stimulated stimulated|advcl|END_ENTITY	Effect of histamine on intercellular_adhesion_molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18 .
12609548	0	interferon-gamma	92,108	interleukin-18	33,47	interferon-gamma	interleukin-18	396054(Tax:9031)	395312(Tax:9031)	Gene	Gene	release|nmod|START_ENTITY based|nmod|release based|nsubj|bioassay bioassay|nmod|END_ENTITY	A sensitive bioassay for chicken interleukin-18 based on the inducible release of preformed interferon-gamma .
14698138	0	interferon-gamma	93,109	interleukin-18	167,181	interferon-gamma	interleukin-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY lipopolysaccharide-induced|dobj|production lipopolysaccharide-induced|nmod|production production|nmod|END_ENTITY	Pretreatment with granulocyte-colony_stimulating_factor decreases lipopolysaccharide-induced interferon-gamma production in mice in association with the production of interleukin-18 .
9620656	0	interferon-gamma	41,57	interleukin-18	12,26	interferon-gamma	interleukin-18	3458	3606	Gene	Gene	factor|amod|START_ENTITY an|dep|factor Overview|dep|an Overview|nmod|END_ENTITY	Overview of interleukin-18 : more than an interferon-gamma inducing factor .
10851461	0	interferon-gamma	102,118	interleukin-2	55,68	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	release|nmod|START_ENTITY affects|dobj|release affects|nsubj|distribution distribution|nmod|END_ENTITY	Dose distribution of low-dose subcutaneous recombinant interleukin-2 affects the secondary release of interferon-gamma in vivo .
15271977	0	interferon-gamma	23,39	interleukin-2	114,127	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	gene|amod|START_ENTITY region|nmod|gene site|nsubj|region site|nmod|remodeling remodeling|nmod|END_ENTITY	A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2 .
15493262	0	interferon-gamma	8,24	interleukin-2	59,72	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
15806975	0	interferon-gamma	50,66	interleukin-2	121,134	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	efficacy|appos|START_ENTITY END_ENTITY|nsubj|efficacy	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
1639351	0	interferon-gamma	154,170	interleukin-2	18,31	interferon-gamma	interleukin-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induces|nmod|production induces|nsubj|Administration Administration|nmod|END_ENTITY	Administration of interleukin-2 induces major histocompatibility complex class II expression on the biliary epithelial cells , possibly through endogenous interferon-gamma production .
17479215	0	interferon-gamma	94,110	interleukin-2	136,149	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	production|nmod|START_ENTITY production|dep|END_ENTITY	Modified penicillin acylase signal peptide allows the periplasmic production of soluble human interferon-gamma but not of soluble human interleukin-2 by the Tat pathway in Escherichia_coli .
1898716	0	interferon-gamma	41,57	interleukin-2	74,87	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	synergizes|amod|START_ENTITY synergizes|nmod|END_ENTITY	Lymphokine-activated killer -LRB- LAK -RRB- cells : interferon-gamma synergizes with interleukin-2 to induce LAK_cytotoxicity in homogeneous leukemic preparations .
1902247	0	interferon-gamma	65,81	interleukin-2	94,107	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Immune cell activation in melioidosis : increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein .
1917162	0	interferon-gamma	64,80	interleukin-2	11,24	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	induction|amod|START_ENTITY effect|nmod|induction causes|dobj|effect causes|nsubj|END_ENTITY	Peri-tumor interleukin-2 causes systemic therapeutic effect via interferon-gamma induction .
19886902	0	interferon-gamma	42,58	interleukin-2	13,26	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	addition|nmod|START_ENTITY END_ENTITY|nmod|addition	Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients , latently infected individuals , and controls .
2113571	0	interferon-gamma	71,87	interleukin-2	31,44	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|trial trial|nmod|END_ENTITY	A phase I trial of recombinant interleukin-2 combined with recombinant interferon-gamma in patients with cancer .
2126575	0	interferon-gamma	117,133	interleukin-2	24,37	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	activity|nmod|START_ENTITY Decrease|dep|activity Decrease|nmod|lymphokine lymphokine|appos|END_ENTITY	Decrease of lymphokine -LRB- interleukin-2 -RRB- - activated killer activity in peripheral blood after administration of natural interferon-gamma .
3119733	0	interferon-gamma	53,69	interleukin-2	15,28	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	deliver|dobj|START_ENTITY way|acl|deliver way|nsubj|END_ENTITY	Is recombinant interleukin-2 the best way to deliver interferon-gamma in human disease ?
7496156	0	interferon-gamma	32,48	interleukin-2	18,31	interferon-gamma	interleukin-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	fibroblasts|amod|START_ENTITY prolongs|nsubj|fibroblasts Immunization|parataxis|prolongs Immunization|nmod|END_ENTITY	Immunization with interleukin-2 / interferon-gamma double cytokine-secreting allogeneic fibroblasts prolongs the survival of mice with melanoma .
7774618	0	interferon-gamma	118,134	interleukin-2	26,39	interferon-gamma	interleukin-2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY primed|nmod|secretion primed|nsubjpass|cells cells|acl|made made|nmod|production production|compound|END_ENTITY	T cells made deficient in interleukin-2 production by exposure to staphylococcal enterotoxin B in vivo are primed for interferon-gamma and interleukin-10 secretion .
7842289	0	interferon-gamma	121,137	interleukin-2	141,154	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	START_ENTITY|nmod|analogs analogs|compound|END_ENTITY	Induction of lymphokine-activated killing with reduced secretion of interleukin-1 beta , tumor necrosis factor-alpha , and interferon-gamma by interleukin-2 analogs .
9101417	0	interferon-gamma	58,74	interleukin-2	12,25	interferon-gamma	interleukin-2	3458	3558	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Recombinant interleukin-2 in combination with recombinant interferon-gamma in patients with advanced malignancy : a phase 1 study .
3118864	0	interferon-gamma	10,26	interleukin-3	38,51	interferon-gamma	interleukin-3	25712(Tax:10116)	24495(Tax:10116)	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the space shuttle .
12127417	0	interferon-gamma	68,84	interleukin-4	24,37	interferon-gamma	interleukin-4	493965(Tax:9685)	751514(Tax:9685)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation by feline interleukin-4 and down-regulation by feline interferon-gamma of major histocompatibility complex class II on cat B-lymphocytes .
19689732	0	interferon-gamma	120,136	interleukin-4	106,119	interferon-gamma	interleukin-4	3458	3565	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Domain analyses of the Runx1 transcription factor responsible for modulating T-cell receptor-beta/CD4 and interleukin-4 / interferon-gamma expression in CD4 -LRB- + -RRB- peripheral T lymphocytes .
2120129	0	interferon-gamma	23,39	interleukin-6	65,78	interferon-gamma	interleukin-6	3458	3569	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|activity activity|amod|END_ENTITY	Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes .
10078962	0	interferon-gamma	95,111	interleukin-7	113,126	interferon-gamma	interleukin-7	25712(Tax:10116)	25647(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma , interleukin-7 , or B7-1-transfected tumor cells .
12600410	0	interferon-gamma	69,85	interleukin-8	14,27	interferon-gamma	interleukin-8	3458	3576	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|levels levels|amod|END_ENTITY	Modulation of interleukin-8 and nitric_oxide_synthase mRNA levels by interferon-gamma in macrophages stimulated with lignin derivatives and lipopolysaccharides .
17536259	0	interferon-gamma	44,60	interleukin-8	196,209	interferon-gamma	interleukin-8	3458	3576	Gene	Gene	production|nmod|START_ENTITY triptolide|nmod|production Effects|nmod|triptolide mononuclear|nsubj|Effects mononuclear|dobj|cell cell|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of triptolide on the production of interferon-gamma in human peripheral blood mononuclear cell and phosphorylation of signal_transducer_and_activator_of_transcription-1 and production of interleukin-8 -RSB- .
7575406	0	interferon-gamma	110,126	interleukin-8	27,40	interferon-gamma	interleukin-8	3458	3576	Gene	Gene	inhibition|nmod|START_ENTITY expression|dep|inhibition expression|amod|END_ENTITY	Lipopolysaccharide-induced interleukin-8 gene expression in human granulocytes : transcriptional inhibition by interferon-gamma .
7655023	0	interferon-gamma	143,159	interleukin-8	35,48	interferon-gamma	interleukin-8	3458	3576	Gene	Gene	regulation|nmod|START_ENTITY induces|parataxis|regulation induces|dobj|END_ENTITY	Leukemia_inhibitory_factor induces interleukin-8 and monocyte_chemotactic_and_activating_factor in human monocytes : differential regulation by interferon-gamma .
2116051	0	interferon-gamma	20,36	interleukin_1	102,115	interferon-gamma	interleukin 1	3458	3552	Gene	Gene	activates|nsubj|START_ENTITY activates|xcomp|produce produce|dobj|END_ENTITY	Recombinant porcine interferon-gamma activates in vitro porcine adherent mononuclear cells to produce interleukin_1 .
2424621	0	interferon-gamma	70,86	interleukin_1	22,35	interferon-gamma	interleukin 1	3458	3552	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The direct effects of interleukin_1 , interleukin_2 , interferon-alpha , interferon-gamma , B-cell growth factor , and a B-cell_differentiation_factor on resting and activated human B cells .
3086435	0	interferon-gamma	37,53	interleukin_1	75,88	interferon-gamma	interleukin 1	3458	3552	Gene	Gene	production|amod|START_ENTITY production|dep|roles roles|nmod|END_ENTITY	Bacterial lipopolysaccharide-induced interferon-gamma production : roles of interleukin_1 and interleukin_2 .
3104062	0	interferon-gamma	13,29	interleukin_1	62,75	interferon-gamma	interleukin 1	3458	3552	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Induction of interferon-gamma production and Ia expression by interleukin_1 in bone marrow culture cells .
8808791	0	interferon-gamma	21,37	interleukin_1_beta	53,71	interferon-gamma	interleukin 1 beta	25712(Tax:10116)	24494(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Inhibitory effect of interferon-gamma on LPS-induced interleukin_1_beta production by isolated adult rat brain microglia .
2105837	0	interferon-gamma	119,135	interleukin_2	65,78	interferon-gamma	interleukin 2	15978(Tax:10090)	16183(Tax:10090)	Gene	Gene	interleukin_2|nmod|START_ENTITY dependence|nmod|interleukin_2 Maintenance|dep|dependence Maintenance|nmod|state state|nmod|END_ENTITY	Maintenance and cure of the L5178Y murine tumor-dormant state by interleukin_2 : dependence of interleukin_2 on induced interferon-gamma and on tumor_necrosis_factor for its antitumor effects .
2424621	0	interferon-gamma	70,86	interleukin_2	37,50	interferon-gamma	interleukin 2	3458	3558	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The direct effects of interleukin_1 , interleukin_2 , interferon-alpha , interferon-gamma , B-cell growth factor , and a B-cell_differentiation_factor on resting and activated human B cells .
2944612	0	interferon-gamma	19,35	interleukin_2	66,79	interferon-gamma	interleukin 2	3458	3558	Gene	Gene	production|amod|START_ENTITY production|nmod|suppression suppression|nmod|synthesis synthesis|amod|END_ENTITY	Histamine inhibits interferon-gamma production via suppression of interleukin_2 synthesis .
2984283	0	interferon-gamma	101,117	interleukin_2	57,70	interferon-gamma	interleukin 2	3458	3558	Gene	Gene	cells|nmod|START_ENTITY cells|nmod|END_ENTITY	Generation of activated killer -LRB- AK -RRB- cells by recombinant interleukin_2 -LRB- rIL_2 -RRB- in collaboration with interferon-gamma -LRB- IFN-gamma -RRB- .
3139787	0	interferon-gamma	112,128	interleukin_2	20,33	interferon-gamma	interleukin 2	3458	3558	Gene	Gene	DNA|amod|START_ENTITY Characterization|nmod|DNA Characterization|nmod|augmentation augmentation|amod|END_ENTITY	Characterization of interleukin_2 and phorbol_myristate_acetate augmentation of expression of transfected human interferon-gamma genomic DNA .
6425204	0	interferon-gamma	88,104	interleukin_2	106,119	interferon-gamma	interleukin 2	3458	3558	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Production of five human lymphokines -LRB- granulocyte-macrophage_colony_stimulating_factor , interferon-gamma , interleukin_2 , macrophage cytotoxicity factor and macrophage_migration_inhibitory_factor -RRB- from Con A stimulated lymphocyte cultures in bioreactors .
2145107	0	interferon-gamma	122,138	interleukin_4	103,116	interferon-gamma	interleukin 4	3458	3565	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Determinants of the immune response in visceral_leishmaniasis : evidence for predominance of endogenous interleukin_4 over interferon-gamma production .
11052818	0	interferon-gamma	29,45	interleukin_6	12,25	interferon-gamma	interleukin 6	15978(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|amod|START_ENTITY role|nmod|production role|nmod|END_ENTITY	The role of interleukin_6 in interferon-gamma production in thermally injured mice .
1899386	0	interferon-gamma	82,98	interleukin_6	22,35	interferon-gamma	interleukin 6	3458	3569	Gene	Gene	synergy|nmod|START_ENTITY induces|parataxis|synergy induces|dobj|production production|amod|END_ENTITY	Interleukin_4 induces interleukin_6 production by endothelial cells : synergy with interferon-gamma .
9485044	0	interferon-gamma	149,165	janus_kinase_2	56,70	interferon-gamma	janus kinase 2	3458	3717	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Human malignant mesothelioma cell growth : activation of janus_kinase_2 and signal_transducer_and_activator_of_transcription_1alpha for inhibition by interferon-gamma .
1551894	0	interferon-gamma	39,55	leucine_aminopeptidase	13,35	interferon-gamma	leucine aminopeptidase	3458	7939	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of leucine_aminopeptidase by interferon-gamma .
15522880	0	interferon-gamma	23,39	mammalian_target_of_rapamycin	101,130	interferon-gamma	mammalian target of rapamycin	3458	2475	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
10086852	0	interferon-gamma	20,36	migration_inhibition_factor	52,79	interferon-gamma	migration inhibition factor	3458	4282	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nsubj|release	In vitro release of interferon-gamma and macrophage migration_inhibition_factor in drug-induced urticaria and angioedema .
16007204	0	interferon-gamma	48,64	mucin	34,39	interferon-gamma	mucin	3458	100508689	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic_acid in human pancreatic_tumour cells involves a reprogramming of signalling pathways .
7842630	0	interferon-gamma	10,26	mucin	49,54	interferon-gamma	mucin	3458	100508689	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian_carcinoma cell lines .
1722413	0	interferon-gamma	70,86	myelin-associated_glycoprotein	19,49	interferon-gamma	myelin-associated glycoprotein	3458	4099	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Down-regulation of myelin-associated_glycoprotein on Schwann cells by interferon-gamma and tumor_necrosis_factor-alpha affects neurite outgrowth .
10842245	0	interferon-gamma	109,125	nerve_growth_factor	57,76	interferon-gamma	nerve growth factor	3458	4803	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Neuronal differentiation in human neuroblastoma cells by nerve_growth_factor following TrkA up-regulation by interferon-gamma .
7510678	0	interferon-gamma	55,71	nitric-oxide_synthase	14,35	interferon-gamma	nitric-oxide synthase	15978(Tax:10090)	18125(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of nitric-oxide_synthase mRNA expression by interferon-gamma and picolinic_acid .
1526278	0	interferon-gamma	52,68	phospholipase_A2	32,48	interferon-gamma	phospholipase A2	3458	151056	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of receptor-coupled phospholipase_A2 by interferon-gamma .
2117030	0	interferon-gamma	47,63	platelet-activating_factor	15,41	interferon-gamma	platelet-activating factor	3458	9768	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of platelet-activating_factor with interferon-gamma in the stimulation of interleukin-1 production by human monocytes .
8403516	0	interferon-gamma	87,103	platelet-derived_growth_factor-B	37,69	interferon-gamma	platelet-derived growth factor-B	3458	5155	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Up-regulation of alveolar macrophage platelet-derived_growth_factor-B -LRB- PDGF-B -RRB- mRNA by interferon-gamma from Mycobacterium tuberculosis antigen -LRB- PPD -RRB- - stimulated lymphocytes .
1561804	0	interferon-gamma	96,112	rTNF_alpha	65,75	interferon-gamma	rTNF alpha	3458	24835(Tax:10116)	Gene	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	In transit metastases of malignant melanoma treated by high dose rTNF_alpha in combination with interferon-gamma and melphalan in isolation perfusion .
15219805	0	interferon-gamma	93,109	retinoic_acid-inducible_gene-I	14,44	interferon-gamma	retinoic acid-inducible gene-I	3458	23586	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of retinoic_acid-inducible_gene-I in vascular smooth muscle cells stimulated with interferon-gamma .
15297736	0	interferon-gamma	102,118	retinoic_acid-inducible_gene-I	16,46	interferon-gamma	retinoic acid-inducible gene-I	3458	23586	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of retinoic_acid-inducible_gene-I in T24 urinary_bladder_carcinoma cells stimulated with interferon-gamma .
7488223	0	interferon-gamma	87,103	signal_transducer_and_activator_of_transcription-3	14,64	interferon-gamma	signal transducer and activator of transcription-3	3458	6774	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- expression by interferon-gamma and interleukin-6 in hepatoma cells .
7627807	0	interferon-gamma	10,26	transforming_growth_factor-beta	48,79	interferon-gamma	transforming growth factor-beta	3458	7040	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of interferon-gamma on the expression of transforming_growth_factor-beta by human corneal fibroblasts : role in corneal immunoseclusion .
20193171	0	interferon-gamma	12,28	transforming_growth_factor_beta	36,67	interferon-gamma	transforming growth factor beta	3458	7040	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of interferon-gamma on the transforming_growth_factor_beta / Smad pathway in keloid-derived fibroblasts -RSB- .
10374812	0	interferon-gamma	20,36	tumor_necrosis_factor	61,82	interferon-gamma	tumor necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|production production|compound|END_ENTITY	Opposite effects of interferon-gamma and prostaglandin_E2 on tumor_necrosis_factor and interleukin-10 production in microglia : a regulatory loop controlling microglia pro- and anti-inflammatory activities .
1790143	0	interferon-gamma	94,110	tumor_necrosis_factor	34,55	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	given|nmod|START_ENTITY given|nsubj|evaluation evaluation|nmod|END_ENTITY	Phase I evaluation of recombinant tumor_necrosis_factor given in combination with recombinant interferon-gamma .
2121882	0	interferon-gamma	140,156	tumor_necrosis_factor	88,109	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	encoding|nmod|START_ENTITY encoding|nmod|END_ENTITY	Gene regulation in macrophage activation : differential regulation of genes encoding for tumor_necrosis_factor , interleukin-1 , JE , and KC by interferon-gamma and lipopolysaccharide .
2497979	0	interferon-gamma	79,95	tumor_necrosis_factor	27,48	interferon-gamma	tumor necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY END_ENTITY|nmod|mice	Induction of an endogenous tumor_necrosis_factor in mice by murine recombinant interferon-gamma combined with a lipid_A subunit analog -LRB- GLA-60 -RRB- of low toxicity .
3005411	0	interferon-gamma	65,81	tumor_necrosis_factor	30,51	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|synthesis synthesis|nmod|receptors receptors|compound|END_ENTITY	Induction of the synthesis of tumor_necrosis_factor receptors by interferon-gamma .
3108017	0	interferon-gamma	82,98	tumor_necrosis_factor	45,66	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|fragmentation fragmentation|acl|caused caused|nmod|END_ENTITY	DNA fragmentation and cytotoxicity caused by tumor_necrosis_factor is enhanced by interferon-gamma .
3112245	0	interferon-gamma	12,28	tumor_necrosis_factor	64,85	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|nmod|END_ENTITY	Recombinant interferon-gamma stimulates the production of human tumor_necrosis_factor in vitro .
3117378	0	interferon-gamma	54,70	tumor_necrosis_factor	14,35	interferon-gamma	tumor necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
3121361	0	interferon-gamma	89,105	tumor_necrosis_factor	16,37	interferon-gamma	tumor necrosis factor	25712(Tax:10116)	103694380	Gene	Gene	Cytotoxicity|nmod|START_ENTITY Cytotoxicity|nmod|END_ENTITY	Cytotoxicity of tumor_necrosis_factor for thyroid epithelial cells and its regulation by interferon-gamma .
3121562	0	interferon-gamma	147,163	tumor_necrosis_factor	100,121	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	and/or|dobj|START_ENTITY and/or|nsubj|lines lines|nmod|END_ENTITY	In vitro growth inhibition of cisplatin-resistant human lung_cancer cell lines by recombinant human tumor_necrosis_factor and/or recombinant human interferon-gamma by virtue of collateral sensitivity .
3131488	0	interferon-gamma	109,125	tumor_necrosis_factor	56,77	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	Augmentation|nmod|START_ENTITY Augmentation|nmod|activity activity|nmod|END_ENTITY	Augmentation of cytotoxic activity of recombinant human tumor_necrosis_factor -LRB- rHu-TNF -RRB- by recombinant human interferon-gamma -LRB- rHu-IFN-gamma -RRB- .
3137565	0	interferon-gamma	68,84	tumor_necrosis_factor	23,44	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	amplifies|amod|START_ENTITY influence|nmod|amplifies END_ENTITY|nmod|influence	Autocrine secretion of tumor_necrosis_factor under the influence of interferon-gamma amplifies HLA-DR gene induction in human monocytes .
8847144	0	interferon-gamma	65,81	tumor_necrosis_factor	23,44	interferon-gamma	tumor necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Anti-tumor activity of tumor_necrosis_factor in combination with interferon-gamma is not affected by prior tolerization .
9459614	0	interferon-gamma	96,112	tumor_necrosis_factor	61,82	interferon-gamma	tumor necrosis factor	3458	7124	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	Regulation of expression of transmembrane and soluble 75 kDa tumor_necrosis_factor receptors by interferon-gamma and granulocyte-macrophage_colony-stimulating_factor involves transcriptional activation .
10865190	0	interferon-gamma	137,153	tumor_necrosis_factor-alpha	13,40	interferon-gamma	tumor necrosis factor-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY prevent|nmod|absence fails|xcomp|prevent fails|nsubj|Induction Induction|nmod|synthase synthase|compound|END_ENTITY	Induction of tumor_necrosis_factor-alpha and inducible nitric_oxide synthase fails to prevent toxoplasmic_encephalitis in the absence of interferon-gamma in genetically resistant BALB/c mice .
11830590	0	interferon-gamma	63,79	tumor_necrosis_factor-alpha	17,44	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of tumor_necrosis_factor-alpha and NF-kappa_B in interferon-gamma - induced CD40 expression in microglia/macrophages .
12788307	0	interferon-gamma	33,49	tumor_necrosis_factor-alpha	98,125	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nmod|END_ENTITY	Prolactin enhances production of interferon-gamma , interleukin-12 , and interleukin-10 , but not of tumor_necrosis_factor-alpha , in a stimulus-specific manner .
1281560	0	interferon-gamma	51,67	tumor_necrosis_factor-alpha	22,49	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	biopsies|nsubj|START_ENTITY biopsies|nmod|expression expression|nmod|END_ENTITY	In situ expression of tumor_necrosis_factor-alpha , interferon-gamma , and interleukin-2 receptors in renal allograft biopsies .
14602203	0	interferon-gamma	138,154	tumor_necrosis_factor-alpha	49,76	interferon-gamma	tumor necrosis factor-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY Active|dobj|modulation Active|dobj|induction induction|nmod|END_ENTITY	Active and inactive influenza virus induction of tumor_necrosis_factor-alpha and nitric_oxide in J774 .1 murine macrophages : modulation by interferon-gamma and failure to induce apoptosis .
2107993	0	interferon-gamma	107,123	tumor_necrosis_factor-alpha	50,77	interferon-gamma	tumor necrosis factor-alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of experimental metastatic ability by tumor_necrosis_factor-alpha alone or in combination with interferon-gamma .
2121884	0	interferon-gamma	8,24	tumor_necrosis_factor-alpha	144,171	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	START_ENTITY|acl|counteracting counteracting|nmod|production production|nmod|END_ENTITY	Role of interferon-gamma in counteracting the suppressive effects of transforming_growth_factor-beta_2 and glucocorticoids on the production of tumor_necrosis_factor-alpha .
2143498	0	interferon-gamma	91,107	tumor_necrosis_factor-alpha	113,140	interferon-gamma	tumor necrosis factor-alpha	15978(Tax:10090)	7124	Gene	Gene	mice|amod|START_ENTITY mice|dep|synergistically synergistically|amod|END_ENTITY	Myelopoiesis-associated suppressor-cell activity in mice with Lewis_lung_carcinoma tumors : interferon-gamma plus tumor_necrosis_factor-alpha synergistically reduce suppressor cell activity .
22507322	0	interferon-gamma	54,70	tumor_necrosis_factor-alpha	116,143	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	-LSB-|compound|START_ENTITY percentages|dep|-LSB- percentages|dep|monocytes monocytes|amod|END_ENTITY	Increased percentages of tumor_necrosis_factor-alpha + / interferon-gamma + T -LSB- corrected -RSB- lymphocytes and calprotectin + / tumor_necrosis_factor-alpha + monocytes in patients with acute Kawasaki_disease .
22507322	0	interferon-gamma	54,70	tumor_necrosis_factor-alpha	25,52	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	-LSB-|compound|START_ENTITY percentages|dep|-LSB- percentages|nmod|+ +|amod|END_ENTITY	Increased percentages of tumor_necrosis_factor-alpha + / interferon-gamma + T -LSB- corrected -RSB- lymphocytes and calprotectin + / tumor_necrosis_factor-alpha + monocytes in patients with acute Kawasaki_disease .
2455573	0	interferon-gamma	211,227	tumor_necrosis_factor-alpha	149,176	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	synergism|nmod|START_ENTITY Enhancement|dep|synergism Enhancement|nmod|colony colony|acl|stimulating stimulating|nmod|END_ENTITY	Enhancement of release from MHC class II antigen-positive monocytes of hematopoietic colony stimulating factors CSF-1 and G-CSF by recombinant human tumor_necrosis_factor-alpha : synergism with recombinant human interferon-gamma .
2502555	0	interferon-gamma	146,162	tumor_necrosis_factor-alpha	13,40	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of tumor_necrosis_factor-alpha on the modulation by interferon-gamma of HLA class II molecules in human thyroid cells and its effect on interferon-gamma binding .
2502555	0	interferon-gamma	62,78	tumor_necrosis_factor-alpha	13,40	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of tumor_necrosis_factor-alpha on the modulation by interferon-gamma of HLA class II molecules in human thyroid cells and its effect on interferon-gamma binding .
3138311	0	interferon-gamma	126,142	tumor_necrosis_factor-alpha	45,72	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	synergism|nmod|START_ENTITY effects|dep|synergism effects|nmod|END_ENTITY	The suppressive effects of recombinant human tumor_necrosis_factor-alpha on normal and malignant myelopoiesis : synergism with interferon-gamma .
7549119	0	interferon-gamma	74,90	tumor_necrosis_factor-alpha	17,44	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|Efficacy Efficacy|nmod|END_ENTITY	-LSB- Efficacy of the tumor_necrosis_factor-alpha -LRB- rTNF-alpha -RRB- associated with interferon-gamma and chemotherapy in extracorporeal circulation in the limb in inoperable malignant_melanoma , soft tissue sarcoma and epidermoid_carcinoma .
8874324	0	interferon-gamma	87,103	tumor_necrosis_factor-alpha	39,66	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Isolated limb perfusion with high-dose tumor_necrosis_factor-alpha in combination with interferon-gamma and melphalan for nonresectable extremity_soft_tissue_sarcomas : a multicenter trial .
8972008	0	interferon-gamma	77,93	tumor_necrosis_factor-alpha	121,148	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Augmented procoagulant activity in cancer patients , treated with recombinant interferon-gamma in addition to recombinant tumor_necrosis_factor-alpha and melphalan .
9550262	0	interferon-gamma	178,194	tumor_necrosis_factor-alpha	93,120	interferon-gamma	tumor necrosis factor-alpha	3458	7124	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|element element|nmod|promoter promoter|appos|element element|amod|distinct distinct|nmod|response response|amod|END_ENTITY	A proximal element within the human alpha_2 -LRB- I -RRB- _ collagen -LRB- COL1A2 -RRB- promoter , distinct from the tumor_necrosis_factor-alpha response element , mediates transcriptional repression by interferon-gamma .
10698041	0	interferon-gamma	11,27	vascular_endothelial_growth_factor	44,78	interferon-gamma	vascular endothelial growth factor	3458	7422	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interferon-gamma on secretion of vascular_endothelial_growth_factor by endometrial_stromal cells .
12816689	0	interferon-gamma	103,119	vascular_endothelial_growth_factor	20,54	interferon-gamma	vascular endothelial growth factor	3458	7422	Gene	Gene	-RSB-|amod|START_ENTITY SKOV3|nmod|-RSB- SKOV3|nsubj|Down-regulation Down-regulation|nmod|expression expression|compound|END_ENTITY	-LSB- Down-regulation of vascular_endothelial_growth_factor expression in ovarian_cancer cell line SKOV3 by interferon-gamma -RSB- .
18060618	0	interferon-gamma	67,83	vascular_endothelial_growth_factor	18,52	interferon-gamma	vascular endothelial growth factor	3458	7422	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|value value|nmod|END_ENTITY	Clinical value of vascular_endothelial_growth_factor combined with interferon-gamma in diagnosing malignant_pleural_effusion and tuberculous_pleural_effusion .
9067408	0	interferon-gamma-inducing_factor	36,68	interleukin-18	69,83	interferon-gamma-inducing factor	interleukin-18	16173(Tax:10090)	16173(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	In vivo antitumor effects of murine interferon-gamma-inducing_factor / interleukin-18 in mice bearing syngeneic Meth A_sarcoma malignant_ascites .
9218751	0	interferon-gamma_inducing_factor	23,55	IFN-gamma	76,85	interferon-gamma inducing factor	IFN-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Systemic production of interferon-gamma_inducing_factor -LRB- IGIF -RRB- versus local IFN-gamma expression involved in the development of Th1 insulitis in NOD mice .
12803856	0	interferon-gamma_receptor_1	45,72	THP1	153,157	interferon-gamma receptor 1	THP1	3459	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Antileishmanial drugs cause up-regulation of interferon-gamma_receptor_1 , not only in the monocytes of visceral_leishmaniasis cases but also in cultured THP1 cells .
9806040	0	interferon-gamma_receptor_1	98,125	interferon-gamma	23,39	interferon-gamma receptor 1	interferon-gamma	3459	3458	Gene	Gene	deficiency|amod|START_ENTITY END_ENTITY|nmod|deficiency	Abnormal regulation of interferon-gamma , interleukin-12 , and tumor_necrosis_factor-alpha in human interferon-gamma_receptor_1 deficiency .
16699517	0	interferon-induced_helicase	96,123	IFIH1	125,130	interferon-induced helicase	IFIH1	64135	64135	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	A genome-wide association study of nonsynonymous SNPs identifies a type_1_diabetes locus in the interferon-induced_helicase -LRB- IFIH1 -RRB- region .
12485430	0	interferon-induced_protein_of_10_kDa	39,75	Substance_P	0,11	interferon-induced protein of 10 kDa	Substance P	3627	6863	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Substance_P enhances the production of interferon-induced_protein_of_10_kDa by human keratinocytes in synergy with interferon-gamma .
11896933	0	interferon-inducible_T_cell_alpha_chemokine	27,70	I-TAC	72,77	interferon-inducible T cell alpha chemokine	I-TAC	56066(Tax:10090)	56066(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	IFN-gamma regulates murine interferon-inducible_T_cell_alpha_chemokine -LRB- I-TAC -RRB- expression in dendritic cell lines and during experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
24794504	0	interferon-inducible_protein_16	25,56	IFI16	18,23	interferon-inducible protein 16	IFI16	3428	3428	Gene	Gene	association|dep|START_ENTITY association|nmod|END_ENTITY	No association of IFI16 -LRB- interferon-inducible_protein_16 -RRB- variants with susceptibility to multiple_sclerosis .
11973642	0	interferon-regulatory_factor-1	62,92	H-REV107-1	36,46	interferon-regulatory factor-1	H-REV107-1	3659	11145	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The class II tumour suppressor gene H-REV107-1 is a target of interferon-regulatory_factor-1 and is involved in IFNgamma-induced cell death in human ovarian_carcinoma cells .
17475929	0	interferon-regulatory_factor_1	33,63	IRF1	65,69	interferon-regulatory factor 1	IRF1	396611(Tax:9823)	396611(Tax:9823)	Gene	Gene	increase|amod|START_ENTITY increase|appos|END_ENTITY	Pig conceptuses increase uterine interferon-regulatory_factor_1 -LRB- IRF1 -RRB- , but restrict expression to stroma through estrogen-induced IRF2 in luminal epithelium .
7529187	0	interferon-stimulated_gene_factor-3	27,62	ISGF-3	64,70	interferon-stimulated gene factor-3	ISGF-3	6773	6773	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Induction of expression of interferon-stimulated_gene_factor-3 -LRB- ISGF-3 -RRB- proteins by interferons .
18322277	0	interferon-tau	94,108	ETS2	169,173	interferon-tau	ETS2	317698(Tax:9913)	281148(Tax:9913)	Gene	Gene	activation|amod|START_ENTITY regulating|dobj|activation regulating|nmod|END_ENTITY	The role of homeobox protein distal-less 3 and its interaction with ETS2 in regulating bovine interferon-tau gene expression-synergistic transcriptional activation with ETS2 .
16792532	0	interferon-tau	59,73	Granulocyte-macrophage_colony-stimulating-factor	0,48	interferon-tau	Granulocyte-macrophage colony-stimulating-factor	317698(Tax:9913)	281095(Tax:9913)	Gene	Gene	secretion|amod|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating-factor increases interferon-tau protein secretion in bovine trophectoderm cells .
25890875	0	interferon-tau	39,53	interferon-tau	90,104	interferon-tau	interferon-tau	317698(Tax:9913)	317698(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and purification of buffalo interferon-tau and efficacy of recombinant buffalo interferon-tau for in vitro embryo development .
25890875	0	interferon-tau	90,104	interferon-tau	39,53	interferon-tau	interferon-tau	317698(Tax:9913)	317698(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression and purification of buffalo interferon-tau and efficacy of recombinant buffalo interferon-tau for in vitro embryo development .
23331180	0	interferon-y	42,54	Interleukin-17	0,14	interferon-y	Interleukin-17	3458	3605	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interleukin-17 enhances the production of interferon-y and tumour_necrosis_factor-a by bone marrow T lymphocytes from patients with lower risk myelodysplastic_syndromes .
21890376	0	interferon-y	59,71	hypoxia-inducible_factor-1a	12,39	interferon-y	hypoxia-inducible factor-1a	3458	3091	Gene	Gene	attenuates|amod|START_ENTITY attenuates|amod|END_ENTITY	Blockade of hypoxia-inducible_factor-1a by YC-1 attenuates interferon-y and tumor_necrosis_factor-a-induced intestinal epithelial barrier_dysfunction .
22422499	0	interferon-y	60,72	interleukin_6	123,136	interferon-y	interleukin 6	3458	3569	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Systemic_sclerosis fibroblasts show specific alterations of interferon-y and tumor_necrosis_factor-a-induced modulation of interleukin_6 and chemokine ligand 2 .
24032631	0	interferon-y	24,36	p38_mitogen-activated_protein_kinase	45,81	interferon-y	p38 mitogen-activated protein kinase	3458	1432	Gene	Gene	START_ENTITY|nmod|signalling signalling|amod|END_ENTITY	Autophagy activation by interferon-y via the p38_mitogen-activated_protein_kinase signalling pathway is involved in macrophage bactericidal activity .
21501162	0	interferon-y	90,102	proteinase-activated_receptor-2	8,39	interferon-y	proteinase-activated receptor-2	3458	2150	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of proteinase-activated_receptor-2 in anti-bacterial and immunomodulatory effects of interferon-y on human neutrophils and monocytes .
19349300	0	interferon_A	33,45	interferon_regulatory_factors_3_and_7	65,102	interferon A	interferon regulatory factors 3 and 7	3439	3661;3665	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of human interferon_A gene expression by interferon_regulatory_factors_3_and_7 .
9773986	0	interferon_alpha-2b	98,117	Transforming_growth_factor-beta	0,31	interferon alpha-2b	Transforming growth factor-beta	3440	7040	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Transforming_growth_factor-beta in thermally injured patients with hypertrophic_scars : effects of interferon_alpha-2b .
21454021	0	interferon_alpha-inducible_protein_6	17,53	IFI6	55,59	interferon alpha-inducible protein 6	IFI6	100909388	100909388	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation on interferon_alpha-inducible_protein_6 -LRB- IFI6 -RRB- gene as a candidate for meat and carcass quality in pig .
10190313	0	interferon_alpha2b	51,69	interleukin-2	37,50	interferon alpha2b	interleukin-2	3440	3558	Gene	Gene	gene|amod|START_ENTITY expression|dep|gene expression|nmod|END_ENTITY	The targeted expression of the human interleukin-2 / interferon_alpha2b fused gene in alpha-fetoprotein-expressing hepatocellular_carcinoma cells .
15371411	0	interferon_consensus_sequence-binding_protein	4,49	neurofibromin_1	95,110	interferon consensus sequence-binding protein	neurofibromin 1	15900(Tax:10090)	18015(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|nmod|END_ENTITY	The interferon_consensus_sequence-binding_protein activates transcription of the gene encoding neurofibromin_1 .
9368190	0	interferon_consensus_sequence_binding_protein	68,113	IFN-alpha	37,46	interferon consensus sequence binding protein	IFN-alpha	15900(Tax:10090)	111654(Tax:10090)	Gene	Gene	messenger|compound|START_ENTITY END_ENTITY|nmod|messenger	Analysis of the antagonist effect of IFN-alpha on IFN-gamma-induced interferon_consensus_sequence_binding_protein messenger RNA in murine macrophages .
23020843	0	interferon_consensus_sequence_binding_protein	31,76	Interferon_regulatory_factor_8	0,30	interferon consensus sequence binding protein	Interferon regulatory factor 8	15900(Tax:10090)	15900(Tax:10090)	Gene	Gene	factor|nsubj|START_ENTITY END_ENTITY|parataxis|factor	Interferon_regulatory_factor_8 / interferon_consensus_sequence_binding_protein is a critical transcription factor for the physiological phenotype of microglia .
12432235	0	interferon_consensus_sequence_binding_protein	94,139	STAT1	60,65	interferon consensus sequence binding protein	STAT1	15900(Tax:10090)	20846(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	CpG DNA induced IL-12_p40 gene activation is independent of STAT1 activation or production of interferon_consensus_sequence_binding_protein .
22520467	0	interferon_gamma	94,110	Atg16L1	35,42	interferon gamma	Atg16L1	3458	55054	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Nondegradative role of Atg5-Atg12 / Atg16L1 autophagy protein complex in antiviral activity of interferon_gamma .
2109036	0	interferon_gamma	85,101	CD4	9,12	interferon gamma	CD4	15978(Tax:10090)	12504(Tax:10090)	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|+ +|compound|END_ENTITY	Roles of CD4 + and CD8 + cells , and the effect of administration of recombinant murine interferon_gamma in listerial infection .
2522938	0	interferon_gamma	39,55	CD8	85,88	interferon gamma	CD8	3458	925	Gene	Gene	expression|compound|START_ENTITY expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Prostaglandin_E2 selectively increases interferon_gamma receptor expression on human CD8 + lymphocytes .
9003466	0	interferon_gamma	105,121	CD80	42,46	interferon gamma	CD86	3458	942	Gene	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|nmod|END_ENTITY	The expression of costimulatory molecules CD80 and CD86 in human carcinoma cell lines : its regulation by interferon_gamma and interleukin-10 .
9326741	0	interferon_gamma	23,39	Growth_hormone	0,14	interferon gamma	Growth hormone	3458	2688	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Growth_hormone induces interferon_gamma production and may play a role in the presentation of alloantigens in vitro .
8206782	0	interferon_gamma	15,31	IFNG	33,37	interferon gamma	IFNG	281237(Tax:9913)	281237(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mapping of the interferon_gamma -LRB- IFNG -RRB- gene in river and swamp buffaloes by in situ hybridization .
1533630	0	interferon_gamma	56,72	IFN_gamma	74,83	interferon gamma	IFN gamma	15978(Tax:10090)	3458	Gene	Gene	Construction|nmod|START_ENTITY Construction|appos|END_ENTITY	Construction , purification , and characterization of new interferon_gamma -LRB- IFN_gamma -RRB- inhibitor proteins .
1373759	0	interferon_gamma	31,47	IgG3	13,17	interferon gamma	IgG3	15978(Tax:10090)	380795(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Induction of IgG3 secretion by interferon_gamma : a model for T cell-independent class switching in response to T cell-independent type 2 antigens .
9490698	0	interferon_gamma	29,45	Interleukin-18	0,14	interferon gamma	Interleukin-18	15978(Tax:10090)	16173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulation|nmod|production regulation|amod|END_ENTITY	Interleukin-18 regulation of interferon_gamma production and cell proliferation as shown in interleukin-1beta-converting_enzyme -LRB- caspase-1 -RRB- - deficient mice .
7538426	0	interferon_gamma	35,51	Lipoprotein_lipase	0,18	interferon gamma	Lipoprotein lipase	3458	4023	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Lipoprotein_lipase synergizes with interferon_gamma to induce macrophage nitric_oxide synthetase mRNA expression and nitric_oxide production .
21812925	0	interferon_gamma	76,92	Transforming_growth_factor_beta	0,31	interferon gamma	Transforming growth factor beta	3458	7040	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|expression expression|compound|END_ENTITY	Transforming_growth_factor_beta expression by human vascular cells inhibits interferon_gamma production and arterial media injury by alloreactive memory T cells .
16051699	0	interferon_gamma	82,98	cystic_fibrosis_transmembrane_conductance_regulator	27,78	interferon gamma	cystic fibrosis transmembrane conductance regulator	3458	1080	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of cystic_fibrosis_transmembrane_conductance_regulator by interferon_gamma in mast cells and epithelial cells .
1361720	0	interferon_gamma	14,30	epidermal_growth_factor_receptor	34,66	interferon gamma	epidermal growth factor receptor	3458	1956	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	The effect of interferon_gamma on epidermal_growth_factor_receptor expression in normal and malignant ovarian epithelial cells .
22323453	0	interferon_gamma	71,87	galectin-9	114,124	interferon gamma	galectin-9	3458	3965	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nmod|END_ENTITY	Tim-3 is an inducible human natural killer cell receptor that enhances interferon_gamma production in response to galectin-9 .
11880162	0	interferon_gamma	43,59	growth_hormone	17,31	interferon gamma	growth hormone	3458	2688	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Human lymphocyte growth_hormone stimulates interferon_gamma production and is inhibited by cortisol and norepinephrine .
16085646	0	interferon_gamma	56,72	interferon_regulatory_factor-1	162,192	interferon gamma	interferon regulatory factor-1	3458	3659	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Physiological and receptor-selective retinoids modulate interferon_gamma signaling by increasing the expression , nuclear localization , and functional activity of interferon_regulatory_factor-1 .
9516152	0	interferon_gamma	97,113	interleukin-6	30,43	interferon gamma	interleukin-6	3458	3569	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Intracellular localization of interleukin-6 in eosinophils from atopic_asthmatics and effects of interferon_gamma .
2125034	0	interferon_gamma	46,62	interleukin_1	18,31	interferon gamma	interleukin 1	3458	3552	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	The modulation of interleukin_1 production by interferon_gamma , and the inhibitory effects of gold compounds .
2530302	0	interferon_gamma	55,71	interleukin_4	12,25	interferon gamma	interleukin 4	3458	3565	Gene	Gene	production|nmod|START_ENTITY suppresses|dobj|production suppresses|nsubj|END_ENTITY	Recombinant interleukin_4 suppresses the production of interferon_gamma by human mononuclear cells .
17179173	0	interferon_gamma	100,116	matrix_metalloproteinase_13	36,63	interferon gamma	matrix metalloproteinase 13	3458	4322	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of interleukin_1-induced matrix_metalloproteinase_13 expression in human chondrocytes by interferon_gamma .
1672545	0	interferon_gamma	13,29	natural_killer_cell_stimulatory_factor	44,82	interferon gamma	natural killer cell stimulatory factor	3458	3593	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Induction of interferon_gamma production by natural_killer_cell_stimulatory_factor : characterization of the responder cells and synergy with other inducers .
7619083	0	interferon_gamma	60,76	serine_proteinase_inhibitor_3	22,51	interferon gamma	serine proteinase inhibitor 3	25712(Tax:10116)	24795(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Activation of the rat serine_proteinase_inhibitor_3 gene by interferon_gamma via the interleukin_6-responsive element .
3134021	0	interferon_gamma	48,64	transferrin_receptor	13,33	interferon gamma	transferrin receptor	3458	7037	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduction of transferrin_receptor expression by interferon_gamma in a human cell line sensitive to its antiproliferative effect .
8100485	0	interferon_gamma	21,37	transforming_growth_factor_beta	61,92	interferon gamma	transforming growth factor beta	3458	7040	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions between interferon_gamma and retinoic_acid with transforming_growth_factor_beta in the induction of immune recognition molecules .
17218947	0	interferon_gamma	110,126	tumor_necrosis_factor	88,109	interferon gamma	tumor necrosis factor	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	therapy|compound|START_ENTITY therapy|amod|END_ENTITY	The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor_necrosis_factor / interferon_gamma antitumor therapy .
15466213	0	interferon_gamma	17,33	tumor_necrosis_factor_alpha	86,113	interferon gamma	tumor necrosis factor alpha	15978(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|synergism synergism|nmod|END_ENTITY	Crucial role for interferon_gamma in the synergism between tumor vasculature-targeted tumor_necrosis_factor_alpha -LRB- NGR-TNF -RRB- and doxorubicin .
9626770	0	interferon_gamma	64,80	tumor_necrosis_factor_alpha	24,51	interferon gamma	tumor necrosis factor alpha	3458	7124	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Increased production of tumor_necrosis_factor_alpha , and not of interferon_gamma , preceding disease activity in patients with multiple_sclerosis .
18593809	0	interferon_gamma_receptor_1	4,31	IFNGR1	33,39	interferon gamma receptor 1	IFNGR1	3459	3459	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	The interferon_gamma_receptor_1 -LRB- IFNGR1 -RRB- -56 C/T gene polymorphism is associated with increased risk of early gastric_carcinoma .
17881657	0	interferon_regulatory_Factor_5	42,72	IRF5	74,78	interferon regulatory Factor 5	IRF5	3663	3663	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An insertion-deletion polymorphism in the interferon_regulatory_Factor_5 -LRB- IRF5 -RRB- gene confers risk of inflammatory_bowel_diseases .
17516545	0	interferon_regulatory_factor-1	16,46	IRF-1	48,53	interferon regulatory factor-1	IRF-1	3659	3659	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Central role of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in controlling retinoic_acid_inducible_gene-I -LRB- RIG-I -RRB- expression .
1680796	0	interferon_regulatory_factor-1	24,54	IRF1	56,60	interferon regulatory factor-1	IRF1	3659	3659	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human interferon_regulatory_factor-1 -LRB- IRF1 -RRB- gene to chromosome 5q23-q31 .
12813035	0	interferon_regulatory_factor-1	73,103	Interferon-gamma	0,16	interferon regulatory factor-1	Interferon-gamma	3659	3458	Gene	Gene	CARD4/NOD1|advcl|START_ENTITY CARD4/NOD1|nsubj|augments augments|amod|END_ENTITY	Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon_regulatory_factor-1 in intestinal epithelial cells .
16707500	0	interferon_regulatory_factor-1	87,117	Interferon_regulatory_factor_8	0,30	interferon regulatory factor-1	Interferon regulatory factor 8	3659	3394	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Interferon_regulatory_factor_8 regulates RANTES gene transcription in cooperation with interferon_regulatory_factor-1 , NF-kappaB , and PU .1 .
20937231	0	interferon_regulatory_factor-1	43,73	Interleukin-10	1,15	interferon regulatory factor-1	Interleukin-10	3659	3586	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	-LSB- Interleukin-10 inhibits the expression of interferon_regulatory_factor-1 with anoxia-reoxygenation in vitro -RSB- .
11022129	0	interferon_regulatory_factor-1	20,50	Prolactin	0,9	interferon regulatory factor-1	Prolactin	24508(Tax:10116)	24683(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Prolactin activates interferon_regulatory_factor-1 expression in normal lympho-hemopoietic cells .
16327981	0	interferon_regulatory_factor-1	26,56	X-box_binding_protein-1	64,87	interferon regulatory factor-1	X-box binding protein-1	3659	7494	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Expression patterns among interferon_regulatory_factor-1 , human X-box_binding_protein-1 , nuclear factor kappa B , nucleophosmin , estrogen_receptor-alpha and progesterone receptor proteins in breast_cancer tissue microarrays .
8910434	0	interferon_regulatory_factor-1	8,38	biliary_glycoprotein	59,79	interferon regulatory factor-1	biliary glycoprotein	3659	634	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Role of interferon_regulatory_factor-1 in the induction of biliary_glycoprotein -LRB- cell CAM-1 -RRB- by interferon-gamma .
14500749	0	interferon_regulatory_factor-1	86,116	endothelin-1	137,149	interferon regulatory factor-1	endothelin-1	3659	1906	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Role for nuclear factor-kappaB and signal_transducer_and_activator_of_transcription_1 / interferon_regulatory_factor-1 in cytokine-induced endothelin-1 release in human vascular smooth muscle cells .
9305901	0	interferon_regulatory_factor-1	36,66	inducible_nitric-oxide_synthase	74,105	interferon regulatory factor-1	inducible nitric-oxide synthase	3659	4843	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Binding of the transcription factor interferon_regulatory_factor-1 to the inducible_nitric-oxide_synthase promoter .
14993214	0	interferon_regulatory_factor-1	141,171	interferon-gamma	40,56	interferon regulatory factor-1	interferon-gamma	3659	3458	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|up-regulation up-regulation|nmod|cells cells|amod|caspase-8 caspase-8|nmod|END_ENTITY	The up-regulation of human caspase-8 by interferon-gamma in breast_tumor cells requires the induction and action of the transcription factor interferon_regulatory_factor-1 .
7499267	0	interferon_regulatory_factor-1	143,173	interferon-gamma	46,62	interferon regulatory factor-1	interferon-gamma	3659	3458	Gene	Gene	cooperation|nmod|START_ENTITY involves|dobj|cooperation involves|csubj|Triggering Triggering|nmod|END_ENTITY	Triggering of the human interleukin-6 gene by interferon-gamma and tumor_necrosis_factor-alpha in monocytic cells involves cooperation between interferon_regulatory_factor-1 , NF kappa B , and Sp1 transcription factors .
7579440	0	interferon_regulatory_factor-1	75,105	interferon-gamma	28,44	interferon regulatory factor-1	interferon-gamma	3659	3458	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubj|inhibition inhibition|nmod|END_ENTITY	Hematopoietic inhibition by interferon-gamma is partially mediated through interferon_regulatory_factor-1 .
8910434	0	interferon_regulatory_factor-1	8,38	interferon-gamma	96,112	interferon regulatory factor-1	interferon-gamma	3659	3458	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of interferon_regulatory_factor-1 in the induction of biliary_glycoprotein -LRB- cell CAM-1 -RRB- by interferon-gamma .
9389691	0	interferon_regulatory_factor-1	14,44	interferon-gamma	118,134	interferon regulatory factor-1	interferon-gamma	3659	3458	Gene	Gene	results|amod|START_ENTITY results|nmod|predominance predominance|nmod|effects effects|nmod|END_ENTITY	Inhibition of interferon_regulatory_factor-1 expression results in predominance of cell growth stimulatory effects of interferon-gamma due to phosphorylation of Stat1 and Stat3 .
16085646	0	interferon_regulatory_factor-1	162,192	interferon_gamma	56,72	interferon regulatory factor-1	interferon gamma	3659	3458	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Physiological and receptor-selective retinoids modulate interferon_gamma signaling by increasing the expression , nuclear localization , and functional activity of interferon_regulatory_factor-1 .
7659094	0	interferon_regulatory_factor-1	43,73	prolactin	82,91	interferon regulatory factor-1	prolactin	3659	5617	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Biphasic transcriptional regulation of the interferon_regulatory_factor-1 gene by prolactin : involvement of gamma-interferon-activated sequence and Stat-related proteins .
17516545	0	interferon_regulatory_factor-1	16,46	retinoic_acid_inducible_gene-I	70,100	interferon regulatory factor-1	retinoic acid inducible gene-I	3659	23586	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Central role of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in controlling retinoic_acid_inducible_gene-I -LRB- RIG-I -RRB- expression .
14565859	0	interferon_regulatory_factor-1_and_interferon_regulatory_factor-2	12,77	IFN-gamma	81,90	interferon regulatory factor-1 and interferon regulatory factor-2	IFN-gamma	3659;3660	3458	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	The role of interferon_regulatory_factor-1_and_interferon_regulatory_factor-2 in IFN-gamma growth inhibition of human breast_carcinoma cell lines .
16806387	0	interferon_regulatory_factor-3	35,65	Ikkepsilon	0,10	interferon regulatory factor-3	Ikkepsilon	3661	9641	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Ikkepsilon regulates viral-induced interferon_regulatory_factor-3 activation via a redox-sensitive pathway .
15178328	0	interferon_regulatory_factor-3	79,109	Rac1	0,4	interferon regulatory factor-3	Rac1	3661	5879	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon_regulatory_factor-3 .
8034037	0	interferon_regulatory_factor_1	42,72	IRF-1	74,79	interferon regulatory factor 1	IRF-1	3659	3659	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Possible role of the transcription factor interferon_regulatory_factor_1 -LRB- IRF-1 -RRB- in the regulation of ornithine_decarboxylase -LRB- ODC -RRB- gene expression during IFN_gamma macrophage activation .
20825659	0	interferon_regulatory_factor_1	181,211	IRF1	218,222	interferon regulatory factor 1	IRF1	3659	3659	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal_transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- - activated transcription of the interferon_regulatory_factor_1 gene -LRB- IRF1 -RRB- .
24954358	0	interferon_regulatory_factor_1	17,47	IRF1	49,53	interferon regulatory factor 1	IRF1	16362(Tax:10090)	16362(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for interferon_regulatory_factor_1 -LRB- IRF1 -RRB- in regulation of bone metabolism .
7537851	0	interferon_regulatory_factor_1	12,42	NF-kappa_B	59,69	interferon regulatory factor 1	NF-kappa B	16362(Tax:10090)	18033(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|advcl|END_ENTITY	Endothelial interferon_regulatory_factor_1 cooperates with NF-kappa_B as a transcriptional activator of vascular_cell_adhesion_molecule_1 .
20825659	0	interferon_regulatory_factor_1	181,211	STAT1	143,148	interferon regulatory factor 1	STAT1	3659	6772	Gene	Gene	gene|amod|START_ENTITY transcription|nmod|gene signal_transducer_and_activator_of_transcription_1|dep|transcription signal_transducer_and_activator_of_transcription_1|appos|END_ENTITY	Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal_transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- - activated transcription of the interferon_regulatory_factor_1 gene -LRB- IRF1 -RRB- .
8663541	0	interferon_regulatory_factor_1	20,50	STAT1	60,65	interferon regulatory factor 1	STAT1	3659	6772	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Cooperative role of interferon_regulatory_factor_1 and p91 -LRB- STAT1 -RRB- response elements in interferon-gamma-inducible expression of human indoleamine 2,3-dioxygenase gene .
20435892	0	interferon_regulatory_factor_1	97,127	interferon_regulatory_factor_8	46,76	interferon regulatory factor 1	interferon regulatory factor 8	3659	3394	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Activation of IL-27_p28 gene transcription by interferon_regulatory_factor_8 in cooperation with interferon_regulatory_factor_1 .
23785404	0	interferon_regulatory_factor_1	16,46	miR-23a	0,7	interferon regulatory factor 1	miR-23a	3659	407010	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-23a targets interferon_regulatory_factor_1 and modulates cellular proliferation and paclitaxel-induced apoptosis in gastric_adenocarcinoma cells .
9213219	0	interferon_regulatory_factor_2	54,84	IRF2	86,90	interferon regulatory factor 2	IRF2	3660	3660	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of the oncogenic transcription factor interferon_regulatory_factor_2 -LRB- IRF2 -RRB- in vitro and in vivo .
20308324	0	interferon_regulatory_factor_3	23,53	Herc5	68,73	interferon regulatory factor 3	Herc5	3661	51191	Gene	Gene	activation|amod|START_ENTITY regulation|nmod|activation regulation|nmod|END_ENTITY	Positive regulation of interferon_regulatory_factor_3 activation by Herc5 via ISG15 modification .
20631144	0	interferon_regulatory_factor_3	57,87	IRF3	89,93	interferon regulatory factor 3	IRF3	3661	3661	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Varicella-zoster_virus immediate-early protein 62 blocks interferon_regulatory_factor_3 -LRB- IRF3 -RRB- phosphorylation at key serine residues : a novel mechanism of IRF3 inhibition among herpesviruses .
22158869	0	interferon_regulatory_factor_3	133,163	IRF3	165,169	interferon regulatory factor 3	IRF3	54131(Tax:10090)	54131(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Phospholipase Cy-2 and intracellular calcium are required for lipopolysaccharide-induced Toll-like_receptor_4 -LRB- TLR4 -RRB- endocytosis and interferon_regulatory_factor_3 -LRB- IRF3 -RRB- activation .
24800889	0	interferon_regulatory_factor_3	24,54	MDA5	100,104	interferon regulatory factor 3	MDA5	3661	64135	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|END_ENTITY	Sustained activation of interferon_regulatory_factor_3 during infection by paramyxoviruses requires MDA5 .
9891032	0	interferon_regulatory_factor_3	18,48	RANTES	73,79	interferon regulatory factor 3	RANTES	3661	6352	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Essential role of interferon_regulatory_factor_3 in direct activation of RANTES chemokine transcription .
22127978	0	interferon_regulatory_factor_3	9,39	interleukin-23	107,121	interferon regulatory factor 3	interleukin-23	3661	27178	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|expression expression|amod|END_ENTITY	Enhanced interferon_regulatory_factor_3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic_lupus_erythematosus .
10770796	0	interferon_regulatory_factor_4	12,42	IRF-4	44,49	interferon regulatory factor 4	IRF-4	3662	3662	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Rel induces interferon_regulatory_factor_4 -LRB- IRF-4 -RRB- expression in lymphocytes : modulation of interferon-regulated gene expression by rel/nuclear factor kappaB .
11749693	0	interferon_regulatory_factor_4	24,54	IRF4	56,60	interferon regulatory factor 4	IRF4	3662	3662	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Possible involvement of interferon_regulatory_factor_4 -LRB- IRF4 -RRB- in a clinical subtype of adult_T-cell_leukemia .
10770796	0	interferon_regulatory_factor_4	12,42	Rel	0,3	interferon regulatory factor 4	Rel	3662	5966	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Rel induces interferon_regulatory_factor_4 -LRB- IRF-4 -RRB- expression in lymphocytes : modulation of interferon-regulated gene expression by rel/nuclear factor kappaB .
20127100	0	interferon_regulatory_factor_5	37,67	IRF5	69,73	interferon regulatory factor 5	IRF5	3663	3663	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Assessment of DNA methylation at the interferon_regulatory_factor_5 -LRB- IRF5 -RRB- promoter region in inflammatory_bowel_diseases .
22053985	0	interferon_regulatory_factor_5	8,38	IRF5	40,44	interferon regulatory factor 5	IRF5	3663	3663	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Loss of interferon_regulatory_factor_5 -LRB- IRF5 -RRB- expression in human ductal_carcinoma correlates with disease stage and contributes to metastasis .
25564941	0	interferon_regulatory_factor_5	45,75	IRF5	77,81	interferon regulatory factor 5	IRF5	3663	3663	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between genetic polymorphisms in interferon_regulatory_factor_5 -LRB- IRF5 -RRB- gene and Malaysian patients with Crohn 's _ disease .
16049006	0	interferon_regulatory_factor_6	61,91	Mammary_serine_protease_inhibitor	0,33	interferon regulatory factor 6	Mammary serine protease inhibitor	3664	5268	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Mammary_serine_protease_inhibitor -LRB- Maspin -RRB- binds directly to interferon_regulatory_factor_6 : identification of a novel serpin partnership .
20435892	0	interferon_regulatory_factor_8	46,76	interferon_regulatory_factor_1	97,127	interferon regulatory factor 8	interferon regulatory factor 1	3394	3659	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Activation of IL-27_p28 gene transcription by interferon_regulatory_factor_8 in cooperation with interferon_regulatory_factor_1 .
18802049	0	interferon_regulatory_factors_1_and_8	55,92	IFN-gamma-induced	0,17	interferon regulatory factors 1 and 8	IFN-gamma-induced	16362;15900	56045(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	IFN-gamma-induced TNF-alpha expression is regulated by interferon_regulatory_factors_1_and_8 in mouse macrophages .
18802049	0	interferon_regulatory_factors_1_and_8	55,92	TNF-alpha	18,27	interferon regulatory factors 1 and 8	TNF-alpha	16362;15900	21926(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	IFN-gamma-induced TNF-alpha expression is regulated by interferon_regulatory_factors_1_and_8 in mouse macrophages .
19349300	0	interferon_regulatory_factors_3_and_7	65,102	interferon_A	33,45	interferon regulatory factors 3 and 7	interferon A	3661;3665	3439	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of human interferon_A gene expression by interferon_regulatory_factors_3_and_7 .
7646436	0	interleukin-1	14,27	C-reactive_protein	31,49	interleukin-1	C-reactive protein	3552	1401	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The effect of interleukin-1 on C-reactive_protein expression in Hep3B cells is exerted at the transcriptional level .
7572270	0	interleukin-1	68,81	CRF	116,119	interleukin-1	CRF	3552	81648(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Molecular mechanisms and neural pathways mediating the influence of interleukin-1 on the activity of neuroendocrine CRF motoneurons in the rat .
7988031	0	interleukin-1	95,108	Cathepsin_B	0,11	interleukin-1	Cathepsin B	3552	1508	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Cathepsin_B and N-acetyl-beta-D-glucosaminidase in human synovial cells in culture : effects of interleukin-1 .
26300253	0	interleukin-1	45,58	Cbl-b	36,41	interleukin-1	Cbl-b	3552	868	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Suppression of E3_ubiquitin_ligase Cbl-b in interleukin-1 signaling -RSB- .
11509229	0	interleukin-1	62,75	Cyclooxygenase_1	0,16	interleukin-1	Cyclooxygenase 1	111343(Tax:10090)	19224(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Cyclooxygenase_1 is not essential for hypophagic responses to interleukin-1 and endotoxin in mice .
8883917	0	interleukin-1	66,79	Fos	50,53	interleukin-1	Fos	111343(Tax:10090)	14281(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|response response|compound|END_ENTITY	The role of cerebral noradrenergic systems in the Fos response to interleukin-1 .
7528576	0	interleukin-1	135,148	Granulocyte-macrophage_colony-stimulating_factor	0,48	interleukin-1	Granulocyte-macrophage colony-stimulating factor	3552	1437	Gene	Gene	downregulated|dep|START_ENTITY upregulated|advcl|downregulated upregulated|nsubj|expression expression|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor expression by human fibroblasts is both upregulated and subsequently downregulated by interleukin-1 .
1280480	0	interleukin-1	146,159	IL-1	161,165	interleukin-1	IL-1	3552	3552	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Human peritoneal mesothelial cells produce many cytokines -LRB- granulocyte colony-stimulating factor -LSB- CSF -RSB- , granulocyte-monocyte-CSF , macrophage-CSF , interleukin-1 -LSB- IL-1 -RSB- , and IL-6 -RRB- and are activated and stimulated to grow by IL-1 .
1312652	0	interleukin-1	11,24	IL-1	26,30	interleukin-1	IL-1	3552	3552	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of interleukin-1 -LRB- IL-1 -RRB- on postsurgical macrophage secretion of protease and protease inhibitor activities .
1692959	0	interleukin-1	40,53	IL-1	55,59	interleukin-1	IL-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	A role for protein kinase C activity in interleukin-1 -LRB- IL-1 -RRB- induction of IL-2 gene expression but not in IL-1 signal transduction .
2505890	0	interleukin-1	137,150	IL-1	152,156	interleukin-1	IL-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Effects of hematopoietic_growth_factor -LRB- GM-CSF : granulocyte-macrophage_colony-stimulating_factor -RRB- on thymocyte proliferation induced by interleukin-1 -LRB- IL-1 -RRB- -RSB- .
2509011	0	interleukin-1	23,36	IL-1	38,42	interleukin-1	IL-1	3552	3552	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Spontaneous release of interleukin-1 -LRB- IL-1 -RRB- from medullary mononuclear cells of pagetic subjects .
2981169	0	interleukin-1	101,114	IL-1	116,120	interleukin-1	IL-1	3552	3552	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Modulation of the sodium_periodate -LRB- NaIO4 -RRB- response in systemic_lupus_erythematosus -LRB- SLE -RRB- : effect of interleukin-1 -LRB- IL-1 -RRB- , interleukin-2 -LRB- IL-2 -RRB- , phorbol_myristate_acetate -LRB- PMA -RRB- , and indomethacin .
7622454	0	interleukin-1	25,38	IL-1	58,62	interleukin-1	IL-1	3552	3552	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|activity activity|compound|END_ENTITY	NF-kappa_B activation by interleukin-1 -LRB- IL-1 -RRB- requires an IL-1 receptor-associated protein kinase activity .
8783045	0	interleukin-1	14,27	IL-1	29,33	interleukin-1	IL-1	3552	3552	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of interleukin-1 -LRB- IL-1 -RRB- on androgen metabolism in human gingival tissue -LRB- HGT -RRB- and periodontal ligament -LRB- PDL -RRB- .
1692959	0	interleukin-1	40,53	IL-2	74,78	interleukin-1	IL-2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	A role for protein kinase C activity in interleukin-1 -LRB- IL-1 -RRB- induction of IL-2 gene expression but not in IL-1 signal transduction .
3061382	0	interleukin-1	23,36	Interleukin-4	0,13	interleukin-1	Interleukin-4	3552	3565	Gene	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits interleukin-1 synthesis by a posttranscriptional mechanism .
7628587	0	interleukin-1	41,54	Interleukin-4	0,13	interleukin-1	Interleukin-4	3552	3565	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits the production of interleukin-1 by adult_T-cell_leukemia cells .
1792940	0	interleukin-1	131,144	Interleukin-6	0,13	interleukin-1	Interleukin-6	3552	3569	Gene	Gene	regulation|nmod|START_ENTITY expression|dep|regulation expression|compound|END_ENTITY	Interleukin-6 messenger RNA expression and interleukin-6 protein secretion in cells isolated from normal human bone : regulation by interleukin-1 .
1918169	0	interleukin-1	101,114	Interleukin-6	0,13	interleukin-1	Interleukin-6	3552	3569	Gene	Gene	regulation|nmod|START_ENTITY production|dep|regulation production|amod|END_ENTITY	Interleukin-6 production by the blast cells of acute_myeloblastic_leukemia : regulation by endogenous interleukin-1 and biological implications .
25109676	0	interleukin-1	15,28	Interleukin-6	0,13	interleukin-1	Interleukin-6	3552	3569	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Interleukin-6 , interleukin-1 gene cluster and interleukin-1_receptor polymorphisms in Iranian patients with juvenile systemic_lupus_erythematosus .
8819122	0	interleukin-1	83,96	Interleukin-6	0,13	interleukin-1	Interleukin-6	3552	3569	Gene	Gene	regulation|nmod|START_ENTITY production|dep|regulation production|amod|END_ENTITY	Interleukin-6 production and secretion in human melanoma cell lines : regulation by interleukin-1 .
1311566	0	interleukin-1	63,76	Mn-superoxide_dismutase	13,36	Interleukin-6	Mn-superoxide dismutase	3569	6648	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Induction of Mn-superoxide_dismutase by tumor necrosis factor , interleukin-1 and interleukin-6 in human hepatoma cells .
7622454	0	interleukin-1	25,38	NF-kappa_B	0,10	interleukin-1	NF-kappa B	3552	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappa_B activation by interleukin-1 -LRB- IL-1 -RRB- requires an IL-1 receptor-associated protein kinase activity .
8244997	0	interleukin-1	132,145	NF-kappa_B	12,22	interleukin-1	NF-kappa B	3552	4790	Gene	Gene	amyloid|advcl|START_ENTITY amyloid|nsubj|role role|nmod|factors factors|amod|END_ENTITY	The role of NF-kappa_B and NF-IL6 transactivating factors in the synergistic activation of human serum amyloid A gene expression by interleukin-1 and interleukin-6 .
17359721	0	interleukin-1	26,39	Sox9	84,88	interleukin-1	Sox9	3552	6662	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The regulation effect of interleukin-1 on expression of cartilage specificity gene Sox9 mRNA in the human intervertebral discs -RSB- .
16543409	0	interleukin-1	44,57	Suppressor_of_cytokine_Signaling-3	0,34	interleukin-1	Suppressor of cytokine Signaling-3	3552	9021	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Suppressor_of_cytokine_Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6 / TAK1 complex .
15686474	0	interleukin-1	56,69	alpha_1-antichymotrypsin	12,36	interleukin-1	alpha 1-antichymotrypsin	3552	12	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Duration of alpha_1-antichymotrypsin gene activation by interleukin-1 is determined by efficiency of inhibitor of nuclear factor kappa B alpha resynthesis in primary human astrocytes .
11841544	0	interleukin-1	66,79	beta-defensin-2	6,21	interleukin-1	beta-defensin-2	3552	100289462	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1 , bacteria , and the state of differentiation .
1868353	0	interleukin-1	66,79	corticotropin-releasing_factor	95,125	interleukin-1	corticotropin-releasing factor	111343(Tax:10090)	12918(Tax:10090)	Gene	Gene	injection|nmod|START_ENTITY behavior|nmod|injection Reduction|nmod|behavior involves|nsubj|Reduction involves|dobj|END_ENTITY	Reduction of exploratory behavior by intraperitoneal injection of interleukin-1 involves brain corticotropin-releasing_factor .
12372984	0	interleukin-1	51,64	corticotropin-releasing_hormone	99,130	interleukin-1	corticotropin-releasing hormone	3552	1392	Gene	Gene	involvement|amod|START_ENTITY involvement|nmod|END_ENTITY	Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotropin-releasing_hormone .
9041934	0	interleukin-1	90,103	cyclooxygenase-2	59,75	interleukin-1	cyclooxygenase-2	3552	5743	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Involvement of nuclear_factor_kappa_B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid_synoviocytes .
8321913	0	interleukin-1	16,29	endothelial_cell_growth_factor	65,95	interleukin-1	endothelial cell growth factor	3552	2246	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Augmentation of interleukin-1 induced prostacyclin production by endothelial_cell_growth_factor : implications for chronic synovitis .
12689655	0	interleukin-1	48,61	factor_VIII	32,43	interleukin-1	factor VIII	3552	2157	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	An antibody to VEGF upregulates factor_VIII via interleukin-1 in activated adrenal cortex-derived capillary endothelial cells .
2505890	0	interleukin-1	137,150	granulocyte-macrophage_colony-stimulating_factor	49,97	interleukin-1	granulocyte-macrophage colony-stimulating factor	111343(Tax:10090)	12981(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|nsubj|Effects Effects|nmod|hematopoietic_growth_factor hematopoietic_growth_factor|appos|GM-CSF GM-CSF|dep|END_ENTITY	-LSB- Effects of hematopoietic_growth_factor -LRB- GM-CSF : granulocyte-macrophage_colony-stimulating_factor -RRB- on thymocyte proliferation induced by interleukin-1 -LRB- IL-1 -RRB- -RSB- .
17027521	0	interleukin-1	26,39	growth_hormone	43,57	interleukin-1	growth hormone	3552	2688	Gene	Gene	START_ENTITY|nmod|action action|amod|END_ENTITY	The inhibitory effects of interleukin-1 on growth_hormone action during catabolic_illness .
1384479	0	interleukin-1	61,74	hepatocyte_growth_factor	17,41	interleukin-1	hepatocyte growth factor	3552	3082	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Up-regulation of hepatocyte_growth_factor gene expression by interleukin-1 in human skin fibroblasts .
15541342	0	interleukin-1	80,93	hepatocyte_growth_factor	14,38	interleukin-1	hepatocyte growth factor	3552	3082	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of hepatocyte_growth_factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma .
15541342	0	interleukin-1	80,93	interferon-gamma	116,132	interleukin-1	interferon-gamma	3552	3458	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Inhibition of hepatocyte_growth_factor induction in human dermal fibroblasts by interleukin-1 and its prevention by interferon-gamma .
1830582	0	interleukin-1	101,114	interleukin-1	72,85	interleukin-1	interleukin-1	3552	3552	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor .
1830582	0	interleukin-1	72,85	interleukin-1	101,114	interleukin-1	interleukin-1	3552	3552	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor .
1832996	0	interleukin-1	14,27	interleukin-1	34,47	interleukin-1	interleukin-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host_disease .
1832996	0	interleukin-1	34,47	interleukin-1	14,27	interleukin-1	interleukin-1	111343(Tax:10090)	111343(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host_disease .
15735988	0	interleukin-1	74,87	interleukin-18	18,32	interleukin-1	interleukin-18	3552	3606	Gene	Gene	-RSB-|amod|START_ENTITY Concentration|nmod|-RSB- Concentration|nmod|receptor receptor|amod|END_ENTITY	-LSB- Concentration of interleukin-18 , interleukin-1beta , soluble receptor for interleukin-1 -LRB- sIL-1RII -RRB- and C-reactive_protein in patients with neuroborreliosis -RSB- .
9877452	0	interleukin-1	152,165	interleukin-18	11,25	interleukin-1	interleukin-18	3552	3606	Gene	Gene	used|advcl|START_ENTITY those|acl|used similar|nmod|those signaling|xcomp|similar activation|advcl|signaling leads|xcomp|activation leads|nsubj|Binding Binding|nmod|IL-1Rrp1 IL-1Rrp1|amod|END_ENTITY	Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1 .
9877452	0	interleukin-1	33,46	interleukin-18	11,25	interleukin-1	interleukin-18	3552	3606	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1 .
19702713	0	interleukin-1	88,101	interleukin-1alpha	49,67	interleukin-1	interleukin-1alpha	3552	3552	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Graves ' _ ophthalmopathy and gene polymorphisms in interleukin-1alpha , interleukin-1beta , interleukin-1 receptor and interleukin-1 receptor antagonist .
11122355	0	interleukin-1	122,135	interleukin-1beta	8,25	interleukin-1	interleukin-1beta	111343(Tax:10090)	16176(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY study|nmod|mice Role|dep|study Role|nmod|factor-alpha factor-alpha|compound|END_ENTITY	Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour : a study with interleukin-1 type I receptor-deficient mice .
15735988	0	interleukin-1	74,87	interleukin-1beta	34,51	interleukin-1	interleukin-1beta	3552	3553	Gene	Gene	-RSB-|amod|START_ENTITY Concentration|nmod|-RSB- Concentration|nmod|receptor receptor|amod|END_ENTITY	-LSB- Concentration of interleukin-18 , interleukin-1beta , soluble receptor for interleukin-1 -LRB- sIL-1RII -RRB- and C-reactive_protein in patients with neuroborreliosis -RSB- .
17763411	0	interleukin-1	98,111	interleukin-1beta	11,28	interleukin-1	interleukin-1beta	3552	3553	Gene	Gene	blockade|amod|START_ENTITY lipopolysaccharide|nmod|blockade Pattern|acl|lipopolysaccharide Pattern|nmod|secretion secretion|amod|END_ENTITY	Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations .
19702713	0	interleukin-1	88,101	interleukin-1beta	69,86	interleukin-1	interleukin-1beta	3552	3553	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Graves ' _ ophthalmopathy and gene polymorphisms in interleukin-1alpha , interleukin-1beta , interleukin-1 receptor and interleukin-1 receptor antagonist .
8288885	0	interleukin-1	74,87	interleukin-2	109,122	interleukin-1	interleukin-2	3552	3558	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	A new human cell line for the molecular dissection of the requirement for interleukin-1 in the production of interleukin-2 by immature T cells .
10408981	0	interleukin-1	37,50	interleukin-6	92,105	interleukin-1	interleukin-6	3552	3569	Gene	Gene	injection|nmod|START_ENTITY stimulates|nsubj|injection stimulates|dobj|release release|nmod|levels levels|nmod|antagonist antagonist|amod|END_ENTITY	Intracerebroventricular injection of interleukin-1 stimulates the release of high levels of interleukin-6 and interleukin-1 receptor antagonist into peripheral blood in the primate .
1370441	0	interleukin-1	70,83	interleukin-6	41,54	interleukin-1	interleukin-6	3552	3569	Gene	Gene	secrete|nmod|START_ENTITY secrete|xcomp|END_ENTITY	Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1 .
1417523	0	interleukin-1	15,28	interleukin-6	32,45	interleukin-1	interleukin-6	3552	3569	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells .
15304279	0	interleukin-1	44,57	interleukin-6	79,92	interleukin-1	interleukin-6	3552	3569	Gene	Gene	induced|nsubj|START_ENTITY induced|dobj|secretion secretion|nmod|END_ENTITY	Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells .
1932373	0	interleukin-1	53,66	interleukin-6	19,32	interleukin-1	interleukin-6	3552	3569	Gene	Gene	induces|advcl|START_ENTITY induces|xcomp|END_ENTITY	Bradykinin induces interleukin-6 and synergizes with interleukin-1 .
2103309	0	interleukin-1	56,69	interleukin-6	79,92	interleukin-1	interleukin-6	3552	3569	Gene	Gene	smooth_muscle_cells|nmod|START_ENTITY Pretreatment|nmod|smooth_muscle_cells enhances|nsubj|Pretreatment enhances|dobj|production production|amod|END_ENTITY	Pretreatment of human vascular smooth_muscle_cells with interleukin-1 enhances interleukin-6 production and cell proliferation -LRB- action of IL-1 on vascular smooth_muscle_cells -RRB- .
2242066	0	interleukin-1	96,109	interleukin-6	22,35	interleukin-1	interleukin-6	3552	3569	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Interleukin-1-induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage .
7745050	0	interleukin-1	24,37	interleukin-6	39,52	interleukin-1	interleukin-6	3552	3569	Gene	Gene	transforming_growth_factor-beta|compound|START_ENTITY transforming_growth_factor-beta|dep|END_ENTITY	Detection of cytokines -LRB- interleukin-1 , interleukin-6 , transforming_growth_factor-beta -RRB- and soluble tumour_necrosis_factor receptors in embryo culture fluids during in-vitro fertilization .
8634432	0	interleukin-1	198,211	interleukin-6	119,132	interleukin-1	interleukin-6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	potentiate|advcl|START_ENTITY potentiate|dobj|induction induction|nmod|END_ENTITY	Six different cytokines that share GP130 as a receptor subunit , induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal_axis by interleukin-1 .
9729338	0	interleukin-1	76,89	interleukin-6	13,26	interleukin-1	interleukin-6	3552	3569	Gene	Gene	relationship|nmod|START_ENTITY Formation|dep|relationship Formation|nmod|END_ENTITY	Formation of interleukin-6 in the brain of the febrile cat : relationship to interleukin-1 .
9647504	0	interleukin-1	23,36	interleukin-6_and_tumor_necrosis_factor-alpha	38,83	interleukin-1	interleukin-6 and tumor necrosis factor-alpha	3552	3569;7124	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	In vitro production of interleukin-1 , interleukin-6_and_tumor_necrosis_factor-alpha by different blood cells in patients on intermittent peritoneal dialysis .
2039486	0	interleukin-1	38,51	interleukin-8	60,73	interleukin-1	interleukin-8	3552	3576	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	1,25 -LRB- OH -RRB- 2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production .
2025651	0	interleukin-1	18,31	lipoprotein_lipase	43,61	interleukin-1	lipoprotein lipase	3552	4023	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Recombinant human interleukin-1 suppresses lipoprotein_lipase activity , but not expression of lipoprotein_lipase mRNA in mesenchymal rat heart cell cultures .
9041934	0	interleukin-1	90,103	nuclear_factor_kappa_B	15,37	interleukin-1	nuclear factor kappa B	3552	4790	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of nuclear_factor_kappa_B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid_synoviocytes .
1989604	0	interleukin-1	18,31	plasminogen_activator_inhibitor-1	41,74	interleukin-1	plasminogen activator inhibitor-1	3552	5054	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Recombinant human interleukin-1 inhibits plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- production by human articular cartilage and chondrocytes .
11816723	0	interleukin-1	88,101	tissue_factor_pathway_inhibitor	14,45	interleukin-1	tissue factor pathway inhibitor	3552	7035	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of tissue_factor_pathway_inhibitor in cardiomyocytes and its upregulation by interleukin-1 .
15455259	0	interleukin-1	96,109	vascular_endothelial_growth_factor	13,47	interleukin-1	vascular endothelial growth factor	3552	7422	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|stromelysin stromelysin|compound|END_ENTITY	Induction of vascular_endothelial_growth_factor and matrix_metalloproteinase-3 -LRB- stromelysin -RRB- by interleukin-1 in human articular chondrocytes and synoviocytes .
8127401	0	interleukin-1-beta	64,82	thyrotropin-releasing_hormone	15,44	interleukin-1-beta	thyrotropin-releasing hormone	24494(Tax:10116)	25569(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of thyrotropin-releasing_hormone gene expression by interleukin-1-beta in the rat : implications for nonthyroidal_illness .
11583588	0	interleukin-1-receptor-associated_kinase	27,67	NF-kappa_B	134,144	interleukin-1-receptor-associated kinase	NF-kappa B	3654	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Functional analysis of the interleukin-1-receptor-associated_kinase -LRB- IRAK-1 -RRB- in interleukin-1 beta-stimulated nuclear factor kappa B -LRB- NF-kappa_B -RRB- pathway activation : IRAK-1 associates with the NF-kappa_B essential modulator -LRB- NEMO -RRB- upon receptor stimulation .
17443229	0	interleukin-1-receptor_antagonist	46,79	IL-1RA	81,87	interleukin-1-receptor antagonist	IL-1RA	3557	3557	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variation in the gene encoding interleukin-1-receptor_antagonist -LRB- IL-1RA -RRB- is associated with altered circulating IL-1RA levels .
9763304	0	interleukin-10	20,34	Alpha-MSH	0,9	interleukin-10	Alpha-MSH	3586	5443	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Alpha-MSH regulates interleukin-10 expression by human keratinocytes .
21830424	0	interleukin-10	95,109	B7-H1	0,5	interleukin-10	B7-H1	3586	29126	Gene	Gene	levels|amod|START_ENTITY correlation|nmod|levels expression|dep|correlation expression|compound|END_ENTITY	B7-H1 up-regulated expression in human hepatocellular_carcinoma tissue : correlation with tumor interleukin-10 levels .
12414752	0	interleukin-10	148,162	CD14	88,92	interleukin-10	CD14	3586	929	Gene	Gene	utilization|nmod|START_ENTITY lipopolysaccharide|nmod|utilization lipopolysaccharide|dobj|expression expression|nmod|END_ENTITY	Nef protein of human immunodeficiency virus and lipopolysaccharide induce expression of CD14 on human monocytes through differential utilization of interleukin-10 .
16148556	0	interleukin-10	59,73	CD14	75,79	interleukin-10	CD14	3586	929	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Are genetic polymorphisms of tumour necrosis factor alpha , interleukin-10 , CD14 endotoxin receptor or manganese_superoxide dismutase associated with alcoholic liver_disease ?
15298560	0	interleukin-10	107,121	CD25	101,105	interleukin-10	CD25	3586	3559	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Induction of T ` regulatory ' cells by standardized house dust mite immunotherapy : an increase in CD4 + CD25 + interleukin-10 + T cells expressing peripheral tissue trafficking markers .
18824533	0	interleukin-10	144,158	CD25	108,112	interleukin-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	independent|advcl|START_ENTITY +|xcomp|independent +|nsubj|role role|nmod|Foxp3 Foxp3|compound|END_ENTITY	Schistosoma_mansoni antigens modulate experimental allergic_asthma in a murine model : a major role for CD4 + CD25 + Foxp3 + T cells independent of interleukin-10 .
20528588	0	interleukin-10	53,67	CD25	16,20	interleukin-10	CD25	3586	3559	Gene	Gene	production|amod|START_ENTITY inducing|dobj|production +|advcl|inducing +|nsubj|defect defect|nmod|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
21982068	0	interleukin-10	18,32	CD25	99,103	interleukin-10	CD25	16153(Tax:10090)	16184(Tax:10090)	Gene	Gene	factor-b|amod|START_ENTITY Neutralization|nmod|factor-b decreases|nsubj|Neutralization decreases|ccomp|+ +|nsubj|percentages percentages|nmod|Foxp3 Foxp3|compound|END_ENTITY	Neutralization of interleukin-10 or transforming growth factor-b decreases the percentages of CD4 + CD25 + Foxp3 + regulatory T cells in septic mice , thereby leading to an improved survival .
8069928	0	interleukin-10	17,31	CD25	220,224	interleukin-10	CD25	3586	3559	Gene	Gene	interplay|nmod|START_ENTITY interplay|dep|synergizes synergizes|nmod|expression expression|amod|IL-2 IL-2|xcomp|enhance enhance|nmod|mechanism mechanism|acl:relcl|different different|nmod|upregulation upregulation|nmod|END_ENTITY	The interplay of interleukin-10 -LRB- IL-10 -RRB- and interleukin-2 -LRB- IL-2 -RRB- in humoral immune responses : IL-10 synergizes with IL-2 to enhance responses of human B lymphocytes in a mechanism which is different from upregulation of CD25 expression .
11979045	0	interleukin-10	12,26	CD4	48,51	interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|generation generation|nmod|+ +|compound|END_ENTITY	The role of interleukin-10 in the generation of CD4 + and CD8 + memory_T cells -LRB- expressing a CD44 + , CD62L - phenotype -RRB- and their contribution to the regulation of immunoglobulin E antibody formation .
12438963	0	interleukin-10	37,51	CD4	79,82	interleukin-10	CD4	3586	920	Gene	Gene	activities|nmod|START_ENTITY activities|nmod|cells cells|compound|END_ENTITY	Synergistic inhibitory activities of interleukin-10 and dexamethasone on human CD4 + T cells .
15298560	0	interleukin-10	107,121	CD4	96,99	interleukin-10	CD4	3586	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Induction of T ` regulatory ' cells by standardized house dust mite immunotherapy : an increase in CD4 + CD25 + interleukin-10 + T cells expressing peripheral tissue trafficking markers .
15556685	0	interleukin-10	78,92	CD4	174,177	interleukin-10	CD4	3586	920	Gene	Gene	secrete|xcomp|START_ENTITY engineered|xcomp|secrete cells|acl|engineered suppress|nsubj|cells suppress|advcl|activating activating|dobj|cells cells|compound|END_ENTITY	Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 -LRB- IL-10 -RRB- suppress Th1-type responses while selectively activating IL-10-producing CD4 + T cells .
15829292	0	interleukin-10	76,90	CD4	146,149	interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppression|nmod|production paralleled|nsubj|suppression paralleled|nmod|cells cells|compound|END_ENTITY	Tumor-induced suppression of interferon-gamma production and enhancement of interleukin-10 production by natural killer -LRB- NK -RRB- cells : paralleled to CD4 + T cells .
17671115	0	interleukin-10	56,70	CD4	19,22	interleukin-10	CD4	3586	920	Gene	Gene	suppression|amod|START_ENTITY secreting|dobj|suppression +|dep|secreting +|nsubj|subset subset|nmod|CD25highFoxp3 CD25highFoxp3|compound|END_ENTITY	A unique subset of CD4 + CD25highFoxp3 + T cells secreting interleukin-10 and transforming_growth_factor-beta1 mediates suppression in the tumor microenvironment .
17996686	0	interleukin-10	52,66	CD4	81,84	interleukin-10	CD4	3586	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	1,25-dihydroxyvitamin _ D3 and dexamethasone increase interleukin-10 production in CD4 + T cells from patients with Crohn 's _ disease .
18824533	0	interleukin-10	144,158	CD4	103,106	interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	independent|advcl|START_ENTITY +|xcomp|independent +|nsubj|role role|nmod|Foxp3 Foxp3|compound|END_ENTITY	Schistosoma_mansoni antigens modulate experimental allergic_asthma in a murine model : a major role for CD4 + CD25 + Foxp3 + T cells independent of interleukin-10 .
19667950	0	interleukin-10	10,24	CD4	57,60	interleukin-10	CD4	3586	920	Gene	Gene	production|amod|START_ENTITY production|nmod|expansion expansion|nmod|CD25 CD25|compound|END_ENTITY	Increased interleukin-10 production without expansion of CD4 + CD25 + T-regulatory cells in early stable renal transplant patients on calcineurin inhibitors .
20528588	0	interleukin-10	53,67	CD4	12,15	interleukin-10	CD4	3586	920	Gene	Gene	production|amod|START_ENTITY inducing|dobj|production +|advcl|inducing +|nsubj|defect defect|nmod|CD25 CD25|compound|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
20528588	0	interleukin-10	53,67	CD4	84,87	interleukin-10	CD4	3586	920	Gene	Gene	production|amod|START_ENTITY inducing|dobj|production inducing|nmod|cells cells|compound|END_ENTITY	A defect of CD4 + CD25 + regulatory T cells in inducing interleukin-10 production from CD4 + T cells under CD46 costimulation in asthma patients .
20722024	0	interleukin-10	111,125	CD4	24,27	interleukin-10	CD4	3586	920	Gene	Gene	response|amod|START_ENTITY role|nmod|response role|dep|cells cells|dep|Expansion Expansion|nmod|CD25 CD25|compound|END_ENTITY	Expansion of intestinal CD4 + CD25 -LRB- high -RRB- Treg cells in patients with ankylosing_spondylitis : a putative role for interleukin-10 in preventing intestinal Th17 response .
21718313	0	interleukin-10	10,24	CD4	53,56	interleukin-10	CD4	3586	920	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Increased interleukin-10 production by ASC-deficient CD4 + T cells impairs bystander T-cell proliferation .
21982068	0	interleukin-10	18,32	CD4	94,97	interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	factor-b|amod|START_ENTITY Neutralization|nmod|factor-b decreases|nsubj|Neutralization decreases|ccomp|+ +|nsubj|percentages percentages|nmod|Foxp3 Foxp3|compound|END_ENTITY	Neutralization of interleukin-10 or transforming growth factor-b decreases the percentages of CD4 + CD25 + Foxp3 + regulatory T cells in septic mice , thereby leading to an improved survival .
22209878	0	interleukin-10	35,49	CD4	63,66	interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|acl|produced produced|nmod|END_ENTITY	Regulatory role of antigen-induced interleukin-10 , produced by CD4 -LRB- + -RRB- T cells , in airway neutrophilia in a murine model for asthma .
24352453	0	interleukin-10	35,49	CD4	77,80	interleukin-10	CD4	3586	920	Gene	Gene	blockade|amod|START_ENTITY and/or|dobj|blockade and/or|nmod|cell cell|compound|END_ENTITY	Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions .
25024370	0	interleukin-10	19,33	CD4	58,61	interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	limits|amod|START_ENTITY induction|nmod|limits antigen-specific|nsubj|induction antigen-specific|dobj|expansion expansion|compound|END_ENTITY	Early induction of interleukin-10 limits antigen-specific CD4 T cell expansion , function , and secondary recall responses during persistent phagosomal infection .
25861842	0	interleukin-10	129,143	CD4	21,24	interleukin-10	CD4	16153(Tax:10090)	12504(Tax:10090)	Gene	Gene	require|xcomp|START_ENTITY induced|advcl|require cells|dep|induced END_ENTITY|dep|cells	Alloantigen-specific CD4 -LRB- + -RRB- regulatory T cells induced in vivo by ultraviolet irradiation after alloantigen immunization require interleukin-10 for their induction and activation , and flexibly mediate bystander immunosuppression of allograft rejection .
8639843	0	interleukin-10	42,56	CD4	70,73	interleukin-10	CD4	3586	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Interferon-alpha stimulates production of interleukin-10 in activated CD4 + T cells and monocytes .
9436700	0	interleukin-10	11,25	CD4	63,66	interleukin-10	CD4	3586	920	Gene	Gene	increases|amod|START_ENTITY increases|nmod|decrease decrease|nmod|T T|compound|END_ENTITY	Peritoneal interleukin-10 increases with decrease in activated CD4 + T lymphocytes in women with endometriosis .
10354374	0	interleukin-10	17,31	CD5	95,98	interleukin-10	CD5	3586	921	Gene	Gene	B|amod|START_ENTITY B|compound|END_ENTITY	Possible role of interleukin-10 in autoantibody production and in the fate of human cord blood CD5 + B lymphocytes .
12765298	0	interleukin-10	83,97	CD5	108,111	interleukin-10	CD5	3586	921	Gene	Gene	START_ENTITY|acl|producing producing|dobj|cells cells|nummod|END_ENTITY	Assessment of Be1 and Be2 cells in systemic_lupus_erythematosus indicates elevated interleukin-10 producing CD5 + B cells .
23363797	0	interleukin-10	10,24	CD5	38,41	interleukin-10	CD5	3586	921	Gene	Gene	cells|amod|START_ENTITY cells|amod|secretion secretion|nmod|B B|compound|END_ENTITY	-LSB- Impaired interleukin-10 secretion by CD5 -LRB- + -RRB- B cells in patients with primary immune_thrombocytopenia -RSB- .
10334386	0	interleukin-10	14,28	CD8	41,44	interleukin-10	CD8	3586	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of interleukin-10 in isolated CD8 + T cells and monocytes from growth factor-mobilized peripheral blood stem cell products : a mechanism of immune_dysfunction .
10733741	0	interleukin-10	35,49	CD8	8,11	interleukin-10	CD8	3586	925	Gene	Gene	secretion|amod|START_ENTITY cells|nmod|secretion cells|nummod|END_ENTITY	Role of CD8 + T cells in endogenous interleukin-10 secretion associated with visceral_leishmaniasis .
12581488	0	interleukin-10	22,36	CD8	75,78	interleukin-10	CD8	3586	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	IFN-alpha2b increases interleukin-10 expression in primary activated human CD8 + T cells .
7890312	0	interleukin-10	10,24	CD8	81,84	interleukin-10	CD8	3586	925	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts .
8611751	0	interleukin-10	106,120	CD8	25,28	interleukin-10	CD8	3586	925	Gene	Gene	producing|xcomp|START_ENTITY inhibits|advcl|producing clone|acl:relcl|inhibits T|dobj|clone T|nsubj|+ +|compound|END_ENTITY	Alpha s1-casein-specific CD8 + T cell clone that inhibits its own interferon-gamma production by producing interleukin-10 .
9105428	0	interleukin-10	69,83	CD8	142,145	interleukin-10	CD8	3586	925	Gene	Gene	promoted|advcl|START_ENTITY promoted|advcl|expressed expressed|nmod|subpopulation subpopulation|compound|END_ENTITY	Autoantibody production in healthy elderly people is not promoted by interleukin-10 although this cytokine is expressed in them by a peculiar CD8 + CD3 + large granular cell subpopulation .
20084080	0	interleukin-10	13,27	Fcalpha_receptor	47,63	interleukin-10	Fcalpha receptor	3586	2204	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of interleukin-10 expression through Fcalpha_receptor in human monocytes and monocyte-derived dendritic cells : role of p38_MAPKinase .
21722102	0	interleukin-10	13,27	GPER	116,120	interleukin-10	GPER	16153(Tax:10090)	76854(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of interleukin-10 in the T helper type 17 effector population by the G_protein_coupled_estrogen_receptor -LRB- GPER -RRB- agonist G-1 .
9681392	0	interleukin-10	30,44	HLA-B27	96,103	interleukin-10	HLA-B27	16153(Tax:10090)	3106	Gene	Gene	Effects|nmod|START_ENTITY Effects|amod|transgenic transgenic|nmod|END_ENTITY	Effects of murine recombinant interleukin-10 on the inflammatory_disease of rats transgenic for HLA-B27 and human beta_2-microglobulin .
10398091	0	interleukin-10	175,189	ICAM-1	25,31	interleukin-10	ICAM-1	3586	3383	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Interferon-gamma-induced ICAM-1 and CD40 expression , complete lack of HLA-DR and CD80 -LRB- B7 .1 -RRB- , and inconsistent HLA-ABC expression in basal_cell_carcinoma : a possible role for interleukin-10 ?
12504574	0	interleukin-10	27,41	ICAM-1	64,70	interleukin-10	ICAM-1	3586	3383	Gene	Gene	Epstein-Barr_virus|amod|START_ENTITY inhibits|nsubj|Epstein-Barr_virus inhibits|dobj|END_ENTITY	Epstein-Barr_virus encoded interleukin-10 inhibits HLA-class I , ICAM-1 , and B7 expression on human monocytes : implications for immune evasion by EBV .
10376939	0	interleukin-10	34,48	IL-10	50,55	interleukin-10	IL-10	3586	3586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Markers in the promoter region of interleukin-10 -LRB- IL-10 -RRB- gene in myasthenia_gravis : implications of diverse effects of IL-10 in the pathogenesis of the disease .
11338880	0	interleukin-10	20,34	IL-10	36,41	interleukin-10	IL-10	3586	3586	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Comparison of serum interleukin-10 -LRB- IL-10 -RRB- levels between normal volunteers and patients with advanced melanoma .
11709312	0	interleukin-10	161,175	IL-10	177,182	interleukin-10	IL-10	3586	3586	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Activation by 9 - -LRB- R -RRB- - -LSB- 2 - -LRB- phosphonomethoxy -RRB- propyl -RSB- adenine of chemokine -LRB- RANTES , macrophage_inflammatory_protein_1alpha -RRB- and cytokine -LRB- tumor_necrosis_factor_alpha , interleukin-10 -LSB- IL-10 -RSB- , IL-1beta -RRB- production .
11810532	0	interleukin-10	10,24	IL-10	26,31	interleukin-10	IL-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of interleukin-10 -LRB- IL-10 -RRB- on experimental LPS-induced acute_lung_injury .
11956022	0	interleukin-10	141,155	IL-10	157,162	interleukin-10	IL-10	3586	3586	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The combination of the interleukin-1alpha -LRB- IL-1alpha-889 -RRB- genotype and the interleukin-10 -LRB- IL-10 ATA -RRB- haplotype is associated with increased interleukin-10 -LRB- IL-10 -RRB- plasma levels in healthy individuals .
1433975	0	interleukin-10	65,79	IL-10	81,86	interleukin-10	IL-10	3586	3586	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Function , molecular structure and gene expression regulation of interleukin-10 -LRB- IL-10 -RRB- -RSB- .
14682393	0	interleukin-10	27,41	IL-10	43,48	interleukin-10	IL-10	3586	3586	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	A base substitution in the interleukin-10 -LRB- IL-10 -RRB- promoter between Sp1 and ets-1 binding sites is not associated with variation of IL-10 levels .
15319176	0	interleukin-10	77,91	IL-10	93,98	interleukin-10	IL-10	3586	3586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A three base pair gene variation within the distal 5 ' - flanking region of the interleukin-10 -LRB- IL-10 -RRB- gene is related to the in vitro IL-10 production capacity of lipopolysaccharide-stimulated peripheral blood mononuclear cells .
19591971	0	interleukin-10	44,58	IL-10	60,65	interleukin-10	IL-10	3586	3586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the promoter region of the interleukin-10 -LRB- IL-10 -RRB- gene in women with cervical_insufficiency .
22393041	0	interleukin-10	162,176	IL-10	178,183	interleukin-10	IL-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Protein kinase C -LRB- PKC -RRB- - extracellular_signal-regulated_kinase_1 / 2 -LRB- ERK1/2 -RRB- signaling cascade regulates glycogen synthase_kinase-3 _ -LRB- GSK-3 -RRB- inhibition-mediated interleukin-10 -LRB- IL-10 -RRB- expression in lipopolysaccharide -LRB- LPS -RRB- - induced endotoxemia .
27016017	0	interleukin-10	8,22	IL-10	24,29	interleukin-10	IL-10	25325(Tax:10116)	25325(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of interleukin-10 -LRB- IL-10 -RRB- in regulation of GABAergic transmission and acute response to ethanol .
7836946	0	interleukin-10	25,39	IL-10	41,46	interleukin-10	IL-10	3586	3586	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Intrathecal synthesis of interleukin-10 -LRB- IL-10 -RRB- in viral and inflammatory_diseases_of_the_central_nervous_system .
8178456	0	interleukin-10	43,57	IL-10	59,64	interleukin-10	IL-10	3586	3586	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of viral and human interleukin-10 -LRB- IL-10 -RRB- by primary B cell tumors and B cell lines .
9234213	0	interleukin-10	15,29	IL-10	31,36	interleukin-10	IL-10	3586	3586	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Amniotic fluid interleukin-10 -LRB- IL-10 -RRB- concentrations during pregnancy and with labor .
9373262	0	interleukin-10	12,26	IL-10	28,33	interleukin-10	IL-10	3586	3586	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of interleukin-10 -LRB- IL-10 -RRB- in IL-15-mediated T-cell responses .
9728752	0	interleukin-10	29,43	IL-10	45,50	interleukin-10	IL-10	16153(Tax:10090)	16153(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Time-dependent expression of interleukin-10 -LRB- IL-10 -RRB- mRNA during the early phase of skin wound healing as a possible indicator of wound vitality .
11196675	0	interleukin-10	103,117	IL-19	68,73	interleukin-10	IL-19	3586	29949	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Cloning , expression and initial characterization of interleukin-19 -LRB- IL-19 -RRB- , a novel homologue of human interleukin-10 -LRB- IL-10 -RRB- .
23898109	0	interleukin-10	15,29	IL10	31,35	interleukin-10	IL10	3586	3586	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Association of interleukin-10 -LRB- IL10 -RRB- promoter genotypes with nasopharyngeal_carcinoma risk in Taiwan .
9010676	0	interleukin-10	91,105	Interferon-gamma	0,16	interleukin-10	Interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY inhibiting|dobj|transcription enhances|advcl|inhibiting enhances|nsubj|END_ENTITY	Interferon-gamma enhances tumor_necrosis_factor-alpha production by inhibiting early phase interleukin-10 transcription .
16115484	0	interleukin-10	16,30	Interleukin-18	0,14	interleukin-10	Interleukin-18	3586	3606	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|dep|ratio	Interleukin-18 : interleukin-10 ratio and in-hospital adverse events in patients with acute_coronary_syndrome .
10085445	0	interleukin-10	30,44	Interleukin-4	0,13	interleukin-10	Interleukin-4	3586	3565	Gene	Gene	cooperates|advcl|START_ENTITY cooperates|nsubj|END_ENTITY	Interleukin-4 cooperates with interleukin-10 to inhibit vascular_permeability_factor release by peripheral blood mononuclear cells from patients with minimal-change nephrotic_syndrome .
12111847	0	interleukin-10	15,29	Interleukin-4	0,13	interleukin-10	Interleukin-4	25325(Tax:10116)	287287(Tax:10116)	Gene	Gene	induce|nsubj|START_ENTITY induce|advmod|END_ENTITY	Interleukin-4 , interleukin-10 , and interleukin-1-receptor antagonist but not transforming_growth_factor-beta induce ramification and reduce adhesion molecule expression of rat microglial cells .
17346426	0	interleukin-10	15,29	Interleukin-6	0,13	interleukin-10	Interleukin-6	3586	3569	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Interleukin-6 , interleukin-10 and heat_shock protein-90 expression in renal_epithelial_neoplasias and surrounding normal-appearing renal_parenchyma .
19762082	0	interleukin-10	23,37	Interleukin-6	0,13	interleukin-10	Interleukin-6	3586	3569	Gene	Gene	production|amod|START_ENTITY leads|nmod|production leads|nsubj|END_ENTITY	Interleukin-6 leads to interleukin-10 production in several human multiple_myeloma cell lines .
20553736	0	interleukin-10	42,56	Pigment_epithelium-derived_factor	0,33	interleukin-10	Pigment epithelium-derived factor	3586	57104	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Pigment_epithelium-derived_factor induces interleukin-10 expression in human macrophages by induction of PPAR_gamma .
10326620	0	interleukin-10	98,112	Pregnancy-specific_glycoprotein	0,31	interleukin-10	Pregnancy-specific glycoprotein	3586	5673	Gene	Gene	expression|amod|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|amod|END_ENTITY	Pregnancy-specific_glycoprotein gene expression in recurrent aborters : a potential correlation to interleukin-10 expression .
8586491	0	interleukin-10	55,69	TH2	93,96	interleukin-10	TH2	16153(Tax:10090)	15111(Tax:10090)	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	Effect of pharmacological agents on the productions of interleukin-10 by the murine D10.G4 .1 TH2 cell line in vitro .
11895951	0	interleukin-10	37,51	THP-1	66,71	interleukin-10	THP-1	3586	2736	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia_burgdorferi lipoproteins .
17485526	0	interleukin-10	10,24	THP-1	72,77	interleukin-10	THP-1	3586	2736	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Orf_virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes , but only partially impairs their proliferation .
25209104	0	interleukin-10	122,136	THP-1	90,95	interleukin-10	THP-1	3586	2736	Gene	Gene	production|amod|START_ENTITY macrophages|nmod|production macrophages|compound|END_ENTITY	Angiotensin AT2 receptor stimulation is anti-inflammatory in lipopolysaccharide-activated THP-1 macrophages via increased interleukin-10 production .
12379886	0	interleukin-10	10,24	TNFalpha	0,8	interleukin-10	TNFalpha	3586	7124	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	TNFalpha , interleukin-10 and interleukin-18 expression in cells of the bronchoalveolar lavage in patients with pulmonary_complications following bone marrow or peripheral stem cell transplantation : a preliminary study .
18565597	0	interleukin-10	99,113	TNFalpha	73,81	interleukin-10	TNFalpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	lacking|xcomp|START_ENTITY mice|acl|lacking END_ENTITY|nmod|mice	Exaggerated expression of skeletal muscle-derived interleukin-6 , but not TNFalpha , in mice lacking interleukin-10 .
9620892	0	interleukin-10	18,32	TNFalpha	44,52	interleukin-10	TNFalpha	3586	7124	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Recombinant human interleukin-10 attenuates TNFalpha production by porcine monocytes .
15270740	0	interleukin-10	27,41	Toll-like_receptor_2	111,131	interleukin-10	Toll-like receptor 2	3586	7097	Gene	Gene	patients|amod|START_ENTITY production|nmod|patients production|nmod|mutation mutation|compound|END_ENTITY	Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like_receptor_2 mutation .
17420232	0	interleukin-10	119,133	Toll-like_receptor_2	70,90	interleukin-10	Toll-like receptor 2	16153(Tax:10090)	24088(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Growth of Yersinia_pseudotuberculosis in mice occurs independently of Toll-like_receptor_2 expression and induction of interleukin-10 .
19255934	0	interleukin-10	9,23	Toll-like_receptor_4	76,96	interleukin-10	Toll-like receptor 4	3586	7099	Gene	Gene	production|amod|START_ENTITY Enhanced|dobj|production Enhanced|nmod|stimulation stimulation|nmod|END_ENTITY	Enhanced interleukin-10 production by dendritic cells upon stimulation with Toll-like_receptor_4 agonists in systemic_sclerosis that is possibly implicated in CCL18 secretion .
23055522	0	interleukin-10	62,76	Toll-like_receptor_4	23,43	interleukin-10	Toll-like receptor 4	3586	7099	Gene	Gene	secretion|amod|START_ENTITY stimulated|dobj|secretion kinase|csubj|stimulated enhances|parataxis|kinase enhances|dobj|END_ENTITY	ABCA1 protein enhances Toll-like_receptor_4 -LRB- TLR4 -RRB- - stimulated interleukin-10 -LRB- IL-10 -RRB- secretion through protein kinase A -LRB- PKA -RRB- activation .
11282558	0	interleukin-10	41,55	Transforming_growth_factor-beta	0,31	interleukin-10	Transforming growth factor-beta	3586	7040	Gene	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits interleukin-10 synthesis by human monocytic cells .
8528940	0	interleukin-10	43,57	Transforming_growth_factor_beta_1	0,33	interleukin-10	Transforming growth factor beta 1	3586	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 inhibits interleukin-10 mRNA expression and production in pokeweed mitogen-stimulated peripheral blood mononuclear cells and T cells .
11577995	0	interleukin-10	28,42	Tumor_necrosis_factor-alpha	0,27	interleukin-10	Tumor necrosis factor-alpha	3586	7124	Gene	Gene	balance|amod|START_ENTITY END_ENTITY|dep|balance	Tumor_necrosis_factor-alpha / interleukin-10 balance in normal and cystic_fibrosis children .
16872712	0	interleukin-10	19,33	adiponectin	6,17	interleukin-10	adiponectin	3586	9370	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Serum adiponectin , interleukin-10 levels and inflammatory markers in the metabolic_syndrome .
9057644	0	interleukin-10	14,28	cyclooxygenase-2	50,66	interleukin-10	cyclooxygenase-2	3586	5743	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils .
8836920	0	interleukin-10	56,70	granzyme_B	86,96	interleukin-10	granzyme B	16153(Tax:10090)	14939(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Anti-CD3-activated killer T cells : interferon-gamma and interleukin-10 cross-regulate granzyme_B expression and the induction of major histocompatibility complex-unrestricted cytotoxicity .
12800242	0	interleukin-10	109,123	insulin-like_growth_factor_1_and_insulin-like_growth_factor_1_receptor	14,84	interleukin-10	insulin-like growth factor 1 and insulin-like growth factor 1 receptor	25325(Tax:10116)	24482;25718	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of insulin-like_growth_factor_1_and_insulin-like_growth_factor_1_receptor and its intervention by interleukin-10 in experimental hepatic_fibrosis .
10088138	0	interleukin-10	104,118	interferon-gamma	68,84	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	secretion|amod|START_ENTITY inhibition|nmod|secretion inhibition|nmod|END_ENTITY	Negative immunoregulatory effects of antidepressants : inhibition of interferon-gamma and stimulation of interleukin-10 secretion .
10417669	0	interleukin-10	112,126	interferon-gamma	72,88	interleukin-10	interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	upregulation|nmod|START_ENTITY inhibits|nmod|upregulation inhibits|dobj|production production|nmod|END_ENTITY	Salivary gland extract from Ixodes ricinus ticks inhibits production of interferon-gamma by the upregulation of interleukin-10 .
12168924	0	interleukin-10	17,31	interferon-gamma	54,70	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	influence|acl|START_ENTITY influence|nmod|production production|amod|END_ENTITY	The influence of interleukin-10 and interleukin-18 on interferon-gamma production by peritoneal exudate cells in patients with gastric_carcinoma .
15809204	0	interleukin-10	25,39	interferon-gamma	7,23	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	markers|amod|START_ENTITY END_ENTITY|appos|markers	Plasma interferon-gamma , interleukin-10 and soluble markers of immune activation in infants with primary adenovirus -LRB- ADV -RRB- and respiratory_syncytial_virus _ -LRB- RSV -RRB- _ infection .
15829292	0	interleukin-10	76,90	interferon-gamma	29,45	interleukin-10	interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|amod|START_ENTITY suppression|nmod|production suppression|nmod|production production|amod|END_ENTITY	Tumor-induced suppression of interferon-gamma production and enhancement of interleukin-10 production by natural killer -LRB- NK -RRB- cells : paralleled to CD4 + T cells .
17005337	0	interleukin-10	111,125	interferon-gamma	148,164	interleukin-10	interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Characterization of Th1 activation by Bartonella_henselae stimulation in BALB/c mice : Inhibitory activities of interleukin-10 for the production of interferon-gamma in spleen cells .
17509455	0	interleukin-10	35,49	interferon-gamma	17,33	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Polymorphisms of interferon-gamma , interleukin-10 , and interleukin-12 genes in myasthenia_gravis .
19124156	0	interleukin-10	58,72	interferon-gamma	13,29	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	expression|amod|START_ENTITY down-regulation|nmod|expression mediated|dobj|down-regulation mediated|nsubj|Mechanism Mechanism|nmod|END_ENTITY	Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression .
20404426	0	interleukin-10	15,29	interferon-gamma	31,47	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	transforming_growth_factor-beta|amod|START_ENTITY transforming_growth_factor-beta|amod|END_ENTITY	Association of interleukin-10 , interferon-gamma , transforming_growth_factor-beta , and tumor_necrosis_factor-alpha gene polymorphisms with long-term kidney allograft survival .
7688311	0	interleukin-10	115,129	interferon-gamma	51,67	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	enhanced|advcl|START_ENTITY enhanced|nsubjpass|Induction Induction|nmod|production production|nmod|END_ENTITY	Induction of macrophage nitric_oxide production by interferon-gamma and tumor_necrosis_factor-alpha is enhanced by interleukin-10 .
8611751	0	interleukin-10	106,120	interferon-gamma	65,81	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	producing|xcomp|START_ENTITY inhibits|advcl|producing inhibits|dobj|production production|amod|END_ENTITY	Alpha s1-casein-specific CD8 + T cell clone that inhibits its own interferon-gamma production by producing interleukin-10 .
9003248	0	interleukin-10	155,169	interferon-gamma	93,109	interleukin-10	interferon-gamma	16153(Tax:10090)	15978(Tax:10090)	Gene	Gene	agents|amod|START_ENTITY END_ENTITY|nmod|agents	Analysis of B7-1_and_B7-2 costimulatory ligands in cultured mouse microglia : upregulation by interferon-gamma and lipopolysaccharide and downregulation by interleukin-10 , prostaglandin_E2 and cyclic_AMP-elevating agents .
9018762	0	interleukin-10	41,55	interferon-gamma	23,39	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Expression of mRNA for interferon-gamma , interleukin-10 , and interleukin-12 -LRB- p40 -RRB- in normal gastric_mucosa_and_in_mucosa_infected with Helicobacter_pylori .
9041358	0	interleukin-10	97,111	interferon-gamma	169,185	interleukin-10	interferon-gamma	3586	3458	Gene	Gene	mRNA|nmod|START_ENTITY induce|dobj|mRNA induce|advcl|induce induce|dobj|END_ENTITY	Leishmania aethiopica derived from diffuse leishmaniasis patients preferentially induce mRNA for interleukin-10 while those from localized leishmaniasis patients induce interferon-gamma .
12620647	0	interleukin-10	45,59	interleukin-10	61,75	interleukin-10	interleukin-10	25325(Tax:10116)	25325(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Regional and temporal expression patterns of interleukin-10 , interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE .
12620647	0	interleukin-10	61,75	interleukin-10	45,59	interleukin-10	interleukin-10	25325(Tax:10116)	25325(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Regional and temporal expression patterns of interleukin-10 , interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE .
22931953	0	interleukin-10	54,68	interleukin-10	89,103	interleukin-10	interleukin-10	3586	3586	Gene	Gene	+|amod|START_ENTITY value|nmod|+ value|dep|patterns patterns|amod|END_ENTITY	Identification and predictive value of interleukin-6 + interleukin-10 + and interleukin-6 - interleukin-10 + cytokine patterns in ST-elevation_acute_myocardial_infarction .
22931953	0	interleukin-10	89,103	interleukin-10	54,68	interleukin-10	interleukin-10	3586	3586	Gene	Gene	patterns|amod|START_ENTITY value|dep|patterns value|nmod|+ +|amod|END_ENTITY	Identification and predictive value of interleukin-6 + interleukin-10 + and interleukin-6 - interleukin-10 + cytokine patterns in ST-elevation_acute_myocardial_infarction .
26629148	0	interleukin-10	89,103	interleukin-2	75,88	interleukin-10	interleukin-2	25325(Tax:10116)	116562(Tax:10116)	Gene	Gene	Bax|dep|START_ENTITY Bax|compound|END_ENTITY	Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2 / interleukin-10 and Bcl-2 / Bax .
10210768	0	interleukin-10	27,41	interleukin-6	12,25	interleukin-10	interleukin-6	3586	3569	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Analysis of interleukin-6 , interleukin-10 and leukemia_inhibitory_factor -LRB- LIF -RRB- production by peripheral blood cells from patients with systemic_lupus_erythematosus identifies LIF as a potential marker of disease activity .
11022130	0	interleukin-10	33,47	interleukin-6	61,74	interleukin-10	interleukin-6	3586	3569	Gene	Gene	IL-10|amod|START_ENTITY IL-10|nmod|cytokines cytokines|amod|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11847480	0	interleukin-10	26,40	interleukin-6	87,100	interleukin-10	interleukin-6	16153(Tax:10090)	16193(Tax:10090)	Gene	Gene	decline|nmod|START_ENTITY contribute|nsubj|decline contribute|nmod|expression expression|nmod|END_ENTITY	An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice .
17305878	0	interleukin-10	32,46	interleukin-6	18,31	interleukin-10	interleukin-6	3586	3569	Gene	Gene	modulates|dep|START_ENTITY modulates|amod|END_ENTITY	Smoking modulates interleukin-6 : interleukin-10 and RANKL : osteoprotegerin ratios in the periodontal tissues .
22931953	0	interleukin-10	54,68	interleukin-6	39,52	interleukin-10	interleukin-6	3586	3569	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	Identification and predictive value of interleukin-6 + interleukin-10 + and interleukin-6 - interleukin-10 + cytokine patterns in ST-elevation_acute_myocardial_infarction .
22931953	0	interleukin-10	89,103	interleukin-6	39,52	interleukin-10	interleukin-6	3586	3569	Gene	Gene	patterns|amod|START_ENTITY value|dep|patterns value|nmod|+ +|amod|END_ENTITY	Identification and predictive value of interleukin-6 + interleukin-10 + and interleukin-6 - interleukin-10 + cytokine patterns in ST-elevation_acute_myocardial_infarction .
23397947	0	interleukin-10	61,75	interleukin-6	46,59	interleukin-10	interleukin-6	3586	3569	Gene	Gene	monocyte_chemoattractant_protein-1|amod|START_ENTITY monocyte_chemoattractant_protein-1|amod|END_ENTITY	Nicotinamide downregulates gene expression of interleukin-6 , interleukin-10 , monocyte_chemoattractant_protein-1 , and tumour_necrosis_factor-a gene expression in HaCaT keratinocytes after ultraviolet B irradiation .
8686529	0	interleukin-10	80,94	interleukin-6	12,25	interleukin-10	interleukin-6	3586	3569	Gene	Gene	influence|nmod|START_ENTITY Increase|dep|influence Increase|nmod|levels levels|amod|END_ENTITY	Increase of interleukin-6 plasma levels after elective craniotomy : influence of interleukin-10 and catecholamines .
12093676	0	interleukin-10	31,45	interleukin-8	14,27	interleukin-10	interleukin-8	3586	3576	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of interleukin-8 by interleukin-10 and transforming_growth_factor_beta in human monocytes infected with mycobacterium_bovis .
9757992	0	interleukin-10	45,59	interleukin-8	63,76	interleukin-10	interleukin-8	3586	3576	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	The effect of transforming growth factor and interleukin-10 on interleukin-8 release by human amniochorion may regulate histologic chorioamnionitis .
25779444	0	interleukin-10	58,72	myocyte_enhancer_factor_2D	21,47	interleukin-10	myocyte enhancer factor 2D	16153(Tax:10090)	17261(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Transcription factor myocyte_enhancer_factor_2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death .
25890150	0	interleukin-10	58,72	myocyte_enhancer_factor_2D	21,47	interleukin-10	myocyte enhancer factor 2D	16153(Tax:10090)	17261(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Transcription factor myocyte_enhancer_factor_2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death .
25890150	0	interleukin-10	58,72	myocyte_enhancer_factor_2D	21,47	interleukin-10	myocyte enhancer factor 2D	16153(Tax:10090)	17261(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Transcription factor myocyte_enhancer_factor_2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death .
21564091	0	interleukin-10	121,135	platelet_endothelial_cell_adhesion_molecule	62,105	interleukin-10	platelet endothelial cell adhesion molecule	25325(Tax:10116)	29583(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Nitric_oxide modulates lipopolysaccharide-induced endothelial platelet_endothelial_cell_adhesion_molecule expression via interleukin-10 .
22350388	0	interleukin-10	55,69	toll-like_receptor_2	14,34	interleukin-10	toll-like receptor 2	3586	7097	Gene	Gene	level|nmod|START_ENTITY level|amod|END_ENTITY	Expression of toll-like_receptor_2 and plasma level of interleukin-10 are associated with outcome in tuberculosis .
19191102	0	interleukin-10	14,28	toll-like_receptor_4	66,86	interleukin-10	toll-like receptor 4	3586	7099	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|acl|signaling signaling|nmod|ligands ligands|amod|END_ENTITY	Inhibition of interleukin-10 signaling in lung dendritic cells by toll-like_receptor_4 ligands .
25633651	0	interleukin-10	28,42	transforming_growth_factor-beta	44,75	interleukin-10	transforming growth factor-beta	3586	7040	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Lack of association between interleukin-10 , transforming_growth_factor-beta gene polymorphisms and juvenile-onset_systemic_lupus_erythematosus .
15627641	0	interleukin-10	105,119	tumor_necrosis_factor	48,69	interleukin-10	tumor necrosis factor	3586	7124	Gene	Gene	role|nmod|START_ENTITY decreases|parataxis|role decreases|dobj|production production|compound|END_ENTITY	Granulocyte_colony-stimulating_factor decreases tumor_necrosis_factor production in whole blood : role of interleukin-10 and prostaglandin_E -LRB- 2 -RRB- .
8764378	0	interleukin-10	20,34	tumor_necrosis_factor	47,68	interleukin-10	tumor necrosis factor	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Enhanced release of interleukin-10 and soluble tumor_necrosis_factor receptors as novel principles of methylxanthine action in murine models of endotoxic_shock .
9086171	0	interleukin-10	43,57	tumor_necrosis_factor	75,96	interleukin-10	tumor necrosis factor	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Differential effects of pentoxifylline and interleukin-10 on production of tumor_necrosis_factor and inducible nitric_oxide synthase by murine macrophages .
23602201	0	interleukin-10	29,43	tumor_necrosis_factor-a	5,28	interleukin-10	tumor necrosis factor-a	3586	7124	Gene	Gene	ratio|amod|START_ENTITY associated|nsubjpass|ratio END_ENTITY|parataxis|associated	High tumor_necrosis_factor-a / interleukin-10 ratio is associated with hepatocellular_carcinoma in patients with chronic_hepatitis_C .
10547095	0	interleukin-10	26,40	tumor_necrosis_factor-alpha	49,76	interleukin-10	tumor necrosis factor-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	reduces|nsubj|START_ENTITY reduces|dobj|production production|amod|END_ENTITY	Systemically administered interleukin-10 reduces tumor_necrosis_factor-alpha production and significantly improves functional recovery following traumatic spinal_cord_injury in rats .
10614840	0	interleukin-10	71,85	tumor_necrosis_factor-alpha	106,133	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Anti-inflammatory cytokine profile in human heart_failure : behavior of interleukin-10 in association with tumor_necrosis_factor-alpha .
10798783	0	interleukin-10	60,74	tumor_necrosis_factor-alpha	31,58	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	The effect of polymorphisms in tumor_necrosis_factor-alpha , interleukin-10 , and transforming_growth_factor-beta1 genes in acute hepatic allograft rejection .
11546981	0	interleukin-10	113,127	tumor_necrosis_factor-alpha	21,48	interleukin-10	tumor necrosis factor-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubjpass|effect effect|nmod|END_ENTITY	Protective effect of tumor_necrosis_factor-alpha against subsequent endotoxemia in mice is mediated , in part , by interleukin-10 .
11727843	0	interleukin-10	22,36	tumor_necrosis_factor-alpha	38,65	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Longitudinal study of interleukin-10 , tumor_necrosis_factor-alpha , anti-U1-snRNP antibody levels and disease activity in patients with mixed_connective_tissue_disease .
12161227	0	interleukin-10	10,24	tumor_necrosis_factor-alpha	46,73	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of interleukin-10 on the production of tumor_necrosis_factor-alpha by peripheral blood mononuclear cells from patients with chronic_heart_failure .
14668613	0	interleukin-10	97,111	tumor_necrosis_factor-alpha	26,53	interleukin-10	tumor necrosis factor-alpha	397106(Tax:9823)	397086(Tax:9823)	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubj|synthesis synthesis|nmod|END_ENTITY	Intrahepatic synthesis of tumor_necrosis_factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase -LRB- Jak -RRB- / signal transducers and activator of transcription -LRB- STAT -RRB- pathway .
15100460	0	interleukin-10	68,82	tumor_necrosis_factor-alpha	39,66	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Ethnic differences in polymorphisms of tumor_necrosis_factor-alpha , interleukin-10 , and transforming_growth_factor-beta1 genes in patients with chronic_hepatitis_C_virus_infection .
15331655	0	interleukin-10	168,182	tumor_necrosis_factor-alpha	84,111	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	increase|nmod|START_ENTITY independent|nmod|increase independent|amod|END_ENTITY	Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor_necrosis_factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10 .
17099512	0	interleukin-10	135,149	tumor_necrosis_factor-alpha	87,114	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Protective effects of heme-oxygenase expression against endotoxic_shock : inhibition of tumor_necrosis_factor-alpha and augmentation of interleukin-10 .
17209781	0	interleukin-10	74,88	tumor_necrosis_factor-alpha	12,39	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	IL-6|amod|START_ENTITY factor-beta|amod|IL-6 transforming|dobj|factor-beta transforming|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , transforming growth factor-beta , interleukin-10 , IL-6 , and interferon-gamma gene polymorphisms in patients with chronic_periodontitis .
17537727	0	interleukin-10	211,225	tumor_necrosis_factor-alpha	72,99	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	production|amod|START_ENTITY increases|nmod|production increases|dobj|expression expression|amod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
18787467	0	interleukin-10	115,129	tumor_necrosis_factor-alpha	133,160	interleukin-10	tumor necrosis factor-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
18787467	0	interleukin-10	115,129	tumor_necrosis_factor-alpha	18,45	interleukin-10	tumor necrosis factor-alpha	25325(Tax:10116)	24835(Tax:10116)	Gene	Gene	fatty_liver_disease|amod|START_ENTITY biomarker|nmod|fatty_liver_disease biomarker|nsubj|Interleukin-10 Interleukin-10|nmod|ratio ratio|amod|END_ENTITY	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
19817985	0	interleukin-10	74,88	tumor_necrosis_factor-alpha	90,117	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	class|amod|START_ENTITY polymorphisms|nmod|class polymorphisms|dep|development development|dep|genes genes|amod|END_ENTITY	Impact of polymorphisms of the major histocompatibility complex class II , interleukin-10 , tumor_necrosis_factor-alpha and cytotoxic_T-lymphocyte_antigen-4 genes on inhibitor development in severe hemophilia_A . .
20163933	0	interleukin-10	61,75	tumor_necrosis_factor-alpha	32,59	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Polymorphisms of genes encoding tumor_necrosis_factor-alpha , interleukin-10 , cluster of differentiation-14 and interleukin-1ra in critically_ill patients .
20684180	0	interleukin-10	12,26	tumor_necrosis_factor-alpha	111,138	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	START_ENTITY|dep|association association|nmod|mortality mortality|nmod|patients patients|nmod|END_ENTITY	Circulating interleukin-10 : association with higher mortality in systolic heart_failure patients with elevated tumor_necrosis_factor-alpha .
7542295	0	interleukin-10	82,96	tumor_necrosis_factor-alpha	36,63	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	cells|amod|START_ENTITY neutralized|nmod|cells neutralized|nsubjpass|Up-regulation Up-regulation|nmod|expression expression|nmod|END_ENTITY	Up-regulation of CD44 expression by tumor_necrosis_factor-alpha is neutralized by interleukin-10 in Langerhans cells .
7589088	0	interleukin-10	27,41	tumor_necrosis_factor-alpha	70,97	interleukin-10	tumor necrosis factor-alpha	16153(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Lipopolysaccharide-induced interleukin-10 in mice : role of endogenous tumor_necrosis_factor-alpha .
7590660	0	interleukin-10	27,41	tumor_necrosis_factor-alpha	53,80	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	release|amod|START_ENTITY release|nmod|overproduction overproduction|amod|END_ENTITY	Role of defective monocyte interleukin-10 release in tumor_necrosis_factor-alpha overproduction in alcoholics cirrhosis .
8865287	0	interleukin-10	10,24	tumor_necrosis_factor-alpha	126,153	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	production|amod|START_ENTITY production|dep|relationship relationship|nmod|production production|nmod|END_ENTITY	Decreased interleukin-10 production by neonatal monocytes and T cells : relationship to decreased production and expression of tumor_necrosis_factor-alpha and its receptors .
9063693	0	interleukin-10	57,71	tumor_necrosis_factor-alpha	15,42	interleukin-10	tumor necrosis factor-alpha	3586	7124	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Suppression of tumor_necrosis_factor-alpha production by interleukin-10 is enhanced by cAMP-elevating agents .
9713135	0	interleukin-10_and_tumor_necrosis_factor-alpha	52,98	interferon-gamma	34,50	interleukin-10 and tumor necrosis factor-alpha	interferon-gamma	3586;7124	3458	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Presence of circulating levels of interferon-gamma , interleukin-10_and_tumor_necrosis_factor-alpha in patients with visceral_leishmaniasis .
16982608	0	interleukin-10_receptor_2	31,56	IL-10	78,83	interleukin-10 receptor 2	IL-10	3588	3586	Gene	Gene	binding|nsubj|START_ENTITY binding|nmod|END_ENTITY	Conformational changes mediate interleukin-10_receptor_2 -LRB- IL-10R2 -RRB- binding to IL-10 and assembly of the signaling complex .
1433976	0	interleukin-11	54,68	AGIF	76,80	interleukin-11	AGIF	3589	3589	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Function , molecular structure and gene expression of interleukin-11 -LRB- IL-11 / AGIF -RRB- -RSB- .
15381181	0	interleukin-11	11,25	IL-11	27,32	interleukin-11	IL-11	3589	3589	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Endogenous interleukin-11 -LRB- IL-11 -RRB- levels in newly diagnosed children with acquired severe_aplastic_anemia -LRB- SAA -RRB- .
8807086	0	interleukin-11	11,25	IL-11	27,32	interleukin-11	IL-11	171040(Tax:10116)	171040(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Endogenous interleukin-11 -LRB- IL-11 -RRB- expression is increased and prophylactic use of exogenous IL-11 enhances platelet recovery and improves survival during thrombocytopenia associated with experimental group B streptococcal_sepsis in neonatal rats .
8940087	0	interleukin-11	39,53	IL-11	55,60	interleukin-11	IL-11	3589	3589	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Functional expression of soluble human interleukin-11 -LRB- IL-11 -RRB- receptor alpha and stoichiometry of in vitro IL-11 receptor complexes with gp130 .
1386338	0	interleukin-11	51,65	IL11	72,76	interleukin-11	IL11	3589	3589	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic sequence and chromosomal location of human interleukin-11 gene -LRB- IL11 -RRB- .
9811056	0	interleukin-11	118,132	Interleukin-1alpha	0,18	interleukin-11	Interleukin-1alpha	3589	3552	Gene	Gene	production|nmod|START_ENTITY stimulate|dobj|production stimulate|nsubj|END_ENTITY	Interleukin-1alpha and tumor_necrosis_factor_alpha synergistically stimulate prostaglandin_E2-dependent production of interleukin-11 in rheumatoid synovial fibroblasts .
10908690	0	interleukin-11	23,37	Interleukin-4	0,13	interleukin-11	Interleukin-4	3589	3565	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits interleukin-11 production by rheumatoid synovial cells .
11141475	0	interleukin-11	28,42	STAT3	68,73	interleukin-11	STAT3	3589	6774	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate_carcinoma .
12239166	0	interleukin-11	34,48	STAT3	59,64	interleukin-11	STAT3	16156(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|induce induce|dobj|END_ENTITY	Heparin acts synergistically with interleukin-11 to induce STAT3 activation and in vitro osteoclast formation .
24036113	0	interleukin-11	81,95	STAT3	123,128	interleukin-11	STAT3	3589	6774	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Bovine lactoferricin-induced anti-inflammation is , in part , via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage .
16489941	0	interleukin-11	43,57	Transforming_growth_factor-beta	0,31	interleukin-11	Transforming growth factor-beta	3589	7040	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Transforming_growth_factor-beta stimulates interleukin-11 production by human periodontal ligament and gingival fibroblasts .
12649145	0	interleukin-11	75,89	VWF	63,66	interleukin-11	VWF	611309(Tax:9615)	399544(Tax:9615)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin -LRB- DDAVP -RRB- .
21276840	0	interleukin-11	56,70	bone_sialoprotein	30,47	interleukin-11	bone sialoprotein	171040(Tax:10116)	24477(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of bone_sialoprotein gene by interleukin-11 .
7545423	0	interleukin-11	19,33	erythropoietin	75,89	interleukin-11	erythropoietin	16156(Tax:10090)	13856(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	In vivo effects of interleukin-11 and stem_cell_factor in combination with erythropoietin in the regulation of erythropoiesis .
10350068	0	interleukin-11	20,34	interleukin-11	47,61	interleukin-11	interleukin-11	3589	3589	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130 .
10350068	0	interleukin-11	47,61	interleukin-11	20,34	interleukin-11	interleukin-11	3589	3589	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	A fusion protein of interleukin-11 and soluble interleukin-11 receptor acts as a superagonist on cells expressing gp130 .
19121317	0	interleukin-11	34,48	interleukin-6	4,17	interleukin-11	interleukin-6	16156(Tax:10090)	16193(Tax:10090)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric_tumor development .
15005008	0	interleukin-11	64,78	interleukin-8	117,130	interleukin-11	interleukin-8	3589	3576	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of physiological concentrations of steroid hormones and interleukin-11 on basal and stimulated production of interleukin-8 by human osteoblast-like cells with different functional profiles .
21688123	0	interleukin-11	27,41	lactoferrin	7,18	interleukin-11	lactoferrin	16156(Tax:10090)	17002(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Bovine lactoferrin induces interleukin-11 production in a hepatitis_mouse model and human intestinal myofibroblasts .
9195779	0	interleukin-11	11,25	stem_cell_factor	98,114	interleukin-11	stem cell factor	171040(Tax:10116)	60427(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin-11 on carboplatin-induced thrombocytopenia in rats and in combination with stem_cell_factor .
15998775	0	interleukin-11	61,75	thrombin	21,29	interleukin-11	thrombin	3589	2147	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Progestin suppresses thrombin - and interleukin-1beta-induced interleukin-11 production in term decidual cells : implications for preterm_delivery .
8786120	0	interleukin-11_receptor_alpha	10,39	IL11RA	46,52	interleukin-11 receptor alpha	IL11RA	3590	3590	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human interleukin-11_receptor_alpha gene -LRB- IL11RA -RRB- : genomic organization and chromosome mapping .
20471186	0	interleukin-12	44,58	TLR21	15,20	interleukin-12	TLR21	404671(Tax:9031)	415623(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY Involvement|nmod|expression Involvement|nmod|END_ENTITY	Involvement of TLR21 in baculovirus-induced interleukin-12 gene expression in avian macrophage-like cell line HD11 .
10651849	0	interleukin-12_p35	56,74	p40	94,97	interleukin-12 p35	p40	3592	3578	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Rare polymorphisms in the promoter regions of the human interleukin-12_p35 and interleukin-12 p40 subunit genes .
12424623	0	interleukin-12_p40	45,63	IL12B	65,70	interleukin-12 p40	IL12B	3593	3593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A promoter polymorphism in the gene encoding interleukin-12_p40 -LRB- IL12B -RRB- is associated with mortality from cerebral_malaria and with reduced nitric_oxide production .
17291992	0	interleukin-12_p40	22,40	calmodulin	81,91	interleukin-12 p40	calmodulin	3593	808	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Nitric_oxide inhibits interleukin-12_p40 through p38 MAPK-mediated regulation of calmodulin and c-rel .
12668156	0	interleukin-12p35	18,35	interleukin-12p40	56,73	interleukin-12p35	interleukin-12p40	3592	3593	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Downregulation of interleukin-12p35 and upregulation of interleukin-12p40 mRNA expression in heart allografts by blood transfusion from granulocyte_colony-stimulating_factor-treated donors .
18485489	0	interleukin-12p40	39,56	IL-12B	63,69	interleukin-12p40	IL-12B	3593	3593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 3 ` UTR 1188_A / C polymorphism in the interleukin-12p40 gene -LRB- IL-12B -RRB- is associated with lepromatous_leprosy in the west of Mexico .
12668156	0	interleukin-12p40	56,73	interleukin-12p35	18,35	interleukin-12p40	interleukin-12p35	3593	3592	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Downregulation of interleukin-12p35 and upregulation of interleukin-12p40 mRNA expression in heart allografts by blood transfusion from granulocyte_colony-stimulating_factor-treated donors .
24034921	0	interleukin-13	64,78	CD4	112,115	interleukin-13	CD4	3596	920	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- 1,25 - -LRB- OH -RRB- 2D3 inhibits lipopolysaccharide-induced expression of interleukin-13 and interleukin-17 in cord blood CD4 + T cells -RSB- .
19333920	0	interleukin-13	87,101	CD8	9,12	interleukin-13	CD8	3596	925	Gene	Gene	levels|nmod|START_ENTITY produce|dobj|levels produce|nsubj|cells cells|compound|END_ENTITY	Effector CD8 + T cells in systemic_sclerosis patients produce abnormally high levels of interleukin-13 associated with increased skin fibrosis .
10651852	0	interleukin-13	34,48	IL-13	50,55	interleukin-13	IL-13	3596	3596	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	A novel polymorphism in the human interleukin-13 -LRB- IL-13 -RRB- promoter .
17287216	0	interleukin-13	30,44	IL-13	46,51	interleukin-13	IL-13	3596	3596	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Lysophosphatidic_acid induces interleukin-13 -LRB- IL-13 -RRB- receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells .
12192597	0	interleukin-13	49,63	IL-13Ralpha2	0,12	interleukin-13	IL-13Ralpha2	3596	3598	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	IL-13Ralpha2 is a glioma-restricted receptor for interleukin-13 .
16423044	0	interleukin-13	24,38	Interleukin-16	0,14	interleukin-13	Interleukin-16	3596	3603	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-16 inhibits interleukin-13 production by allergen-stimulated blood mononuclear cells .
12956740	0	interleukin-13	40,54	NF-AT2	132,138	interleukin-13	NF-AT2	3596	4772	Gene	Gene	correlates|amod|START_ENTITY correlates|nmod|expression expression|nmod|END_ENTITY	Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun_B : relevance to immunotherapy .
20051514	0	interleukin-13	37,51	NF45	0,4	interleukin-13	NF45	3596	3608	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells .
18497474	0	interleukin-13	73,87	STAT6	0,5	interleukin-13	STAT6	3596	6778	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	STAT6 mediates apoptosis of human coronary arterial endothelial cells by interleukin-13 .
19487697	0	interleukin-13	103,117	activating_transcription_factor-2	126,159	interleukin-13	activating transcription factor-2	3596	1386	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	House dust mite allergen Der f 2-induced phospholipase_D1 activation is critical for the production of interleukin-13 through activating_transcription_factor-2 activation in human bronchial epithelial cells .
18360690	0	interleukin-13	13,27	beta-catenin	31,43	interleukin-13	beta-catenin	3596	1499	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Influence of interleukin-13 on beta-catenin levels in eosinophilic chronic rhinosinusitis cell culture .
15730785	0	interleukin-13	12,26	gob-5	34,39	interleukin-13	gob-5	16163(Tax:10090)	23844(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effects of interleukin-13 on the gob-5 and MUC5AC expression in lungs of a murine asthmatic model -RSB- .
19739097	0	interleukin-13	21,35	interleukin-13	49,63	interleukin-13	interleukin-13	3596	3596	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells .
19739097	0	interleukin-13	49,63	interleukin-13	21,35	interleukin-13	interleukin-13	3596	3596	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells .
16236975	0	interleukin-13	78,92	interleukin-5	56,69	interleukin-13	interleukin-5	16163(Tax:10090)	16191(Tax:10090)	Gene	Gene	dependent|amod|START_ENTITY END_ENTITY|dep|dependent	Pneumothorax-associated pleural_eosinophilia in mice is interleukin-5 but not interleukin-13 dependent .
25782381	0	interleukin-13	64,78	surfactant_protein_D	93,113	interleukin-13	surfactant protein D	3596	6441	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Expression of surfactant_protein_D in airways of asthmatics and interleukin-13 modulation of surfactant_protein_D in human models of airway epithelium .
25848896	0	interleukin-13	64,78	surfactant_protein_D	93,113	interleukin-13	surfactant protein D	3596	6441	Gene	Gene	modulation|amod|START_ENTITY modulation|nmod|END_ENTITY	Expression of surfactant_protein_D in airways of asthmatics and interleukin-13 modulation of surfactant_protein_D in human models of airway epithelium .
25683991	0	interleukin-13	11,25	zonula_occludens-1	63,81	interleukin-13	zonula occludens-1	3596	7082	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of interleukin-13 and montelukast on the expression of zonula_occludens-1 in human podocytes .
12605119	0	interleukin-15	84,98	CD103	133,138	interleukin-15	CD103	3600	3682	Gene	Gene	START_ENTITY|nmod|development development|nmod|T T|compound|END_ENTITY	Tubulitis in renal allograft rejection : role of transforming_growth_factor-beta and interleukin-15 in development and maintenance of CD103 + intraepithelial T cells .
8639878	0	interleukin-15	8,22	CD56	51,55	interleukin-15	CD56	3600	4684	Gene	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Role of interleukin-15 in the development of human CD56 + natural killer cells from CD34 + hematopoietic progenitor cells .
19578849	0	interleukin-15	43,57	CD8	102,105	interleukin-15	CD8	3600	925	Gene	Gene	START_ENTITY|nmod|expansion expansion|nmod|T T|compound|END_ENTITY	Differential effects of interleukin-12 and interleukin-15 on expansion of NK_cell_receptor-expressing CD8 + T cells .
16919968	0	interleukin-15	23,37	IL-15L	44,50	interleukin-15	IL-15L	654826(Tax:7955)	494451(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of an interleukin-15 like -LRB- IL-15L -RRB- gene from zebrafish -LRB- Danio_rerio -RRB- .
21765616	0	interleukin-15	65,79	IL-8	137,141	interleukin-15	IL-8	3600	3576	Gene	Gene	START_ENTITY|dep|crosstalk crosstalk|nmod|END_ENTITY	Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin_D -LRB- 3 -RRB- : a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic_rhinitis .
24603895	0	interleukin-15	27,41	Interleukin-15	0,14	interleukin-15	Interleukin-15	3600	3600	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Interleukin-15 and soluble interleukin-15 receptor a in coronary_artery_disease patients : association with epicardial fat and indices of adipose tissue distribution .
15225362	0	interleukin-15	14,28	interleukin-15	29,43	interleukin-15	interleukin-15	3600	3600	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Targeting the interleukin-15 / interleukin-15 receptor system in inflammatory autoimmune_diseases .
15225362	0	interleukin-15	29,43	interleukin-15	14,28	interleukin-15	interleukin-15	3600	3600	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Targeting the interleukin-15 / interleukin-15 receptor system in inflammatory autoimmune_diseases .
16547946	0	interleukin-15	19,33	interleukin-15	4,18	interleukin-15	interleukin-15	3600	3600	Gene	Gene	system|amod|START_ENTITY system|dep|END_ENTITY	The interleukin-15 / interleukin-15 receptor system as a model for juxtacrine and reverse signaling .
16547946	0	interleukin-15	4,18	interleukin-15	19,33	interleukin-15	interleukin-15	3600	3600	Gene	Gene	system|dep|START_ENTITY system|amod|END_ENTITY	The interleukin-15 / interleukin-15 receptor system as a model for juxtacrine and reverse signaling .
18697873	0	interleukin-15	20,34	interleukin-15	48,62	interleukin-15	interleukin-15	3600	3600	Gene	Gene	Association|nmod|START_ENTITY Association|dep|END_ENTITY	Association between interleukin-15 and obesity : interleukin-15 as a potential regulator of fat mass .
18697873	0	interleukin-15	48,62	interleukin-15	20,34	interleukin-15	interleukin-15	3600	3600	Gene	Gene	Association|dep|START_ENTITY Association|nmod|END_ENTITY	Association between interleukin-15 and obesity : interleukin-15 as a potential regulator of fat mass .
10447730	0	interleukin-15	131,145	interleukin-2	166,179	interleukin-15	interleukin-2	3600	3558	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Activation , survival and apoptosis of CD45RO + and CD45RO - T cells of human_immunodeficiency_virus-infected individuals : effects of interleukin-15 and comparison with interleukin-2 .
11340297	0	interleukin-15	54,68	interleukin-2	40,53	interleukin-15	interleukin-2	3600	3558	Gene	Gene	stimulation|amod|START_ENTITY T|dep|stimulation tyrosine|dep|T tyrosine|nmod|END_ENTITY	Gab2 is phosphorylated on tyrosine upon interleukin-2 / interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a .
12969549	0	interleukin-15	7,21	interleukin-2	104,117	interleukin-15	interleukin-2	3600	3558	Gene	Gene	cells|amod|START_ENTITY Use|nmod|cells Use|dep|comparison comparison|nmod|END_ENTITY	Use of interleukin-15 for preparation of adherent NK cells from human peripheral blood : comparison with interleukin-2 .
7553894	0	interleukin-15	58,72	interleukin-2	118,131	interleukin-15	interleukin-2	16168(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY evaluating|dobj|activity Studies|acl|evaluating Studies|dep|comparison comparison|nmod|END_ENTITY	Studies evaluating the antitumor activity and toxicity of interleukin-15 , a new T_cell_growth_factor : comparison with interleukin-2 .
10233698	0	interleukin-16	21,35	CD4	67,70	interleukin-16	CD4	3603	920	Gene	Gene	START_ENTITY|nmod|production production|nmod|T T|compound|END_ENTITY	Inhibitory effect of interleukin-16 on interleukin-2 production by CD4 + T cells .
11196708	0	interleukin-16	55,69	IL-16	71,76	interleukin-16	IL-16	3603	3603	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new polymorphism in the promoter region of the human interleukin-16 -LRB- IL-16 -RRB- gene .
11240037	0	interleukin-16	62,76	IL-16	78,83	interleukin-16	IL-16	3603	3603	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human focal cerebral_infarctions induce differential lesional interleukin-16 -LRB- IL-16 -RRB- expression confined to infiltrating granulocytes , CD8 + T-lymphocytes and activated microglia/macrophages .
10233698	0	interleukin-16	21,35	interleukin-2	39,52	interleukin-16	interleukin-2	3603	3558	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Inhibitory effect of interleukin-16 on interleukin-2 production by CD4 + T cells .
16704642	0	interleukin-16	16,30	macrophage-derived_chemokine	32,60	interleukin-16	macrophage-derived chemokine	3603	6367	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Significance of interleukin-16 , macrophage-derived_chemokine , eosinophil cationic protein and soluble E-selectin in reflecting disease activity of atopic_dermatitis -- from laboratory parameters to clinical scores .
22170065	0	interleukin-17	84,98	CD4	117,120	interleukin-17	CD4	16171(Tax:10090)	12504(Tax:10090)	Gene	Gene	differentiation|nmod|START_ENTITY regulates|nmod|differentiation regulates|parataxis|producing producing|dobj|+ +|compound|END_ENTITY	Transforming growth factor-b protein inversely regulates in vivo differentiation of interleukin-17 -LRB- IL-17 -RRB- - producing CD4 + and CD8 + T cells .
22321808	0	interleukin-17	46,60	CD4	0,3	interleukin-17	CD4	449530(Tax:9823)	404704(Tax:9823)	Gene	Gene	sources|nmod|START_ENTITY sources|nsubj|+ +|compound|END_ENTITY	CD4 + and y TCR + T lymphocytes are sources of interleukin-17 in swine .
24102576	0	interleukin-17	12,26	CD4	69,72	interleukin-17	CD4	3605	920	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Recovery of interleukin-17 production from interleukin-15-stimulated CD4 + mononuclear cells in HIV-1-infected patients with sustained viral suppression .
24338253	0	interleukin-17	78,92	CD4	107,110	interleukin-17	CD4	3605	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	The effects of vitamin_D on allergen-induced expression of interleukin-13 and interleukin-17 in cord blood CD4 T cells .
24681356	0	interleukin-17	13,27	CD8	31,34	interleukin-17	CD8	3605	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Secretion of interleukin-17 by CD8 + T cells expressing CD146 -LRB- MCAM -RRB- .
23448394	0	interleukin-17	14,28	IL-17	118,123	interleukin-17	IL-17	3605	3605	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of interleukin-17 associated with disease progression and liver_fibrosis with hepatitis_B_virus infection : IL-17 in HBV_infection .
23868508	0	interleukin-17	96,110	IL-17	112,117	interleukin-17	IL-17	3605	3605	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The effect of vitamin_A supplementation on retinoic_acid-related orphan receptor yt -LRB- RORyt -RRB- and interleukin-17 -LRB- IL-17 -RRB- gene expression in Avonex-treated multiple sclerotic patients .
19062315	0	interleukin-17	31,45	IRF-4-binding_protein	0,21	interleukin-17	IRF-4-binding protein	16171(Tax:10090)	23853(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	IRF-4-binding_protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor .
9672148	0	interleukin-17	71,85	granulocyte_colony-stimulating_factor	14,51	interleukin-17	granulocyte colony-stimulating factor	16171(Tax:10090)	12985(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of granulocyte_colony-stimulating_factor gene expression by interleukin-17 .
26170965	0	interleukin-17	10,24	receptor-interacting_protein_4	28,58	interleukin-17	receptor-interacting protein 4	3605	54101	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of interleukin-17 on receptor-interacting_protein_4 expression and keratinocyte proliferation .
24045154	0	interleukin-17A	39,54	CREB	25,29	interleukin-17A	CREB	16171(Tax:10090)	12912(Tax:10090)	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis .
25146432	0	interleukin-17A	36,51	IL-17A	53,59	interleukin-17A	IL-17A	3605	3605	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Heterogeneous expression pattern of interleukin-17A -LRB- IL-17A -RRB- , IL-17F and their receptors in synovium of rheumatoid_arthritis , psoriatic_arthritis and osteoarthritis : possible explanation for non-response to anti-IL-17 therapy ?
20070409	0	interleukin-17A	28,43	Toll-like_receptor_6	0,20	interleukin-17A	Toll-like receptor 6	16171(Tax:10090)	21899(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY drives|dobj|expression drives|nsubj|END_ENTITY	Toll-like_receptor_6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis .
22540331	0	interleukin-17F	23,38	Interleukin-33	0,14	interleukin-17F	Interleukin-33	112744	90865	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-33 induces interleukin-17F in bronchial epithelial cells .
20642578	0	interleukin-17F	45,60	insulin-like_growth_factor-I	13,41	interleukin-17F	insulin-like growth factor-I	112744	3479	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of insulin-like_growth_factor-I by interleukin-17F in bronchial epithelial cells .
15860756	0	interleukin-18	24,38	Angiotensin_II	0,14	interleukin-18	Angiotensin II	16173(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Angiotensin_II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells : a novel cross-talk in the pathogenesis of atherosclerosis .
18320471	0	interleukin-18	27,41	Angiotensin_subtype_1_receptor	69,99	interleukin-18	Angiotensin subtype 1 receptor	29197(Tax:10116)	24180(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Mechanical stretch induced interleukin-18 -LRB- IL-18 -RRB- expression through Angiotensin_subtype_1_receptor -LRB- AT1R -RRB- and endothelin-1 in cardiomyocytes .
12871213	0	interleukin-18	126,140	CD8	0,3	interleukin-18	CD8	3606	925	Gene	Gene	secrete|xcomp|START_ENTITY activate|xcomp|secrete +|parataxis|activate +|nsubj|END_ENTITY	CD8 + immunoregulatory cells in the graft-versus-host reaction : CD8 T cells activate dendritic cells to secrete interleukin-12 / interleukin-18 and induce T helper 1 autoantibody .
12871213	0	interleukin-18	126,140	CD8	63,66	interleukin-18	CD8	3606	925	Gene	Gene	secrete|xcomp|START_ENTITY activate|xcomp|secrete activate|nsubj|cells cells|compound|END_ENTITY	CD8 + immunoregulatory cells in the graft-versus-host reaction : CD8 T cells activate dendritic cells to secrete interleukin-12 / interleukin-18 and induce T helper 1 autoantibody .
9849583	0	interleukin-18	59,73	CD8	27,30	interleukin-18	CD8	3606	925	Gene	Gene	lymphocytes|advcl|START_ENTITY lymphocytes|nsubj|activation activation|nmod|T T|compound|END_ENTITY	Direct activation of human CD8 + cytotoxic T lymphocytes by interleukin-18 .
15816833	0	interleukin-18	52,66	Corticotropin-releasing_hormone	0,31	interleukin-18	Corticotropin-releasing hormone	3606	1392	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone -LRB- CRH -RRB- downregulates interleukin-18 expression in human HaCaT keratinocytes by activation of p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- pathway .
24581851	0	interleukin-18	21,35	Endothelin-1	0,12	interleukin-18	Endothelin-1	3606	1906	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Endothelin-1 induces interleukin-18 expression in human osteoblasts .
10225924	0	interleukin-18	8,22	IL-18	24,29	interleukin-18	IL-18	16173(Tax:10090)	16173(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of interleukin-18 -LRB- IL-18 -RRB- in mycobacterial_infection in IL-18-gene-disrupted mice .
10505749	0	interleukin-18	15,29	IL-18	31,36	interleukin-18	IL-18	3606	3606	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of interleukin-18 -LRB- IL-18 -RRB- in mixed lymphocyte reactions -LRB- MLR -RRB- .
11125306	0	interleukin-18	14,28	IL-18	30,35	interleukin-18	IL-18	3606	3606	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of interleukin-18 -LRB- IL-18 -RRB- expression in keratinocytes -LRB- HaCaT -RRB- : implications for early wound healing .
15809203	0	interleukin-18	33,47	IL-18	49,54	interleukin-18	IL-18	3606	3606	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated systemic levels of free interleukin-18 -LRB- IL-18 -RRB- in patients with Crohn 's _ disease .
18320471	0	interleukin-18	27,41	IL-18	43,48	interleukin-18	IL-18	29197(Tax:10116)	29197(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mechanical stretch induced interleukin-18 -LRB- IL-18 -RRB- expression through Angiotensin_subtype_1_receptor -LRB- AT1R -RRB- and endothelin-1 in cardiomyocytes .
25776473	0	interleukin-18	31,45	IL-18	47,52	interleukin-18	IL-18	3606	3606	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Clinical significance of serum interleukin-18 -LRB- IL-18 -RRB- levels in patients with gastric_cancer .
11477102	0	interleukin-18	17,31	NF_kappa_B	71,81	interleukin-18	NF kappa B	3606	4790	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	A novel role for interleukin-18 in adhesion molecule induction through NF_kappa_B and phosphatidylinositol -LRB- PI -RRB- 3-kinase-dependent signal transduction pathways .
12048347	0	interleukin-18	22,36	Th1	58,61	interleukin-18	Th1	16173(Tax:10090)	57314(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|response response|amod|END_ENTITY	High-dose recombinant interleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma .
18835036	0	interleukin-18	20,34	Transferrin	0,11	interleukin-18	Transferrin	3606	7018	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transferrin induces interleukin-18 expression in chronic_myeloid_leukemia cell line , K-562 .
15178407	0	interleukin-18	36,50	beta2-AR	66,74	interleukin-18	beta2-AR	3606	154	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Beta-adrenergic stimulation induces interleukin-18 expression via beta2-AR , PI3K , Akt , IKK , and NF-kappaB .
16339124	0	interleukin-18	18,32	insulin	66,73	interleukin-18	insulin	3606	3630	Gene	Gene	role|nmod|START_ENTITY associated|nsubj|role associated|nmod|resistance resistance|compound|END_ENTITY	Potential role of interleukin-18 in liver_disease associated with insulin resistance .
10942393	0	interleukin-18	20,34	interferon-gamma	138,154	interleukin-18	interferon-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	Coadministration|acl|START_ENTITY induces|nsubj|Coadministration induces|dobj|response response|dep|role role|nmod|production production|compound|END_ENTITY	Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice : critical role of natural killer cell interferon-gamma production and STAT-mediated signal transduction .
11061569	0	interleukin-18	81,95	interferon-gamma	32,48	interleukin-18	interferon-gamma	3606	3458	Gene	Gene	reactions|amod|START_ENTITY downregulation|nmod|reactions inhibit|nmod|downregulation inhibit|dobj|production production|amod|END_ENTITY	Calcineurin antagonists inhibit interferon-gamma production by downregulation of interleukin-18 in human mixed lymphocyte reactions .
11474118	0	interleukin-18	60,74	interferon-gamma	8,24	interleukin-18	interferon-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY wound|nmod|presence wound|nsubj|Lack Lack|nmod|production production|amod|END_ENTITY	Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing .
12364868	0	interleukin-18	167,181	interferon-gamma	86,102	interleukin-18	interferon-gamma	3606	3458	Gene	Gene	stimulated|advcl|START_ENTITY Effect|acl|stimulated Effect|nmod|END_ENTITY	Effect of histamine on intercellular_adhesion_molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18 .
12609548	0	interleukin-18	33,47	interferon-gamma	92,108	interleukin-18	interferon-gamma	395312(Tax:9031)	396054(Tax:9031)	Gene	Gene	bioassay|nmod|START_ENTITY based|nsubj|bioassay based|nmod|release release|nmod|END_ENTITY	A sensitive bioassay for chicken interleukin-18 based on the inducible release of preformed interferon-gamma .
14698138	0	interleukin-18	167,181	interferon-gamma	93,109	interleukin-18	interferon-gamma	16173(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY lipopolysaccharide-induced|nmod|production lipopolysaccharide-induced|dobj|production production|amod|END_ENTITY	Pretreatment with granulocyte-colony_stimulating_factor decreases lipopolysaccharide-induced interferon-gamma production in mice in association with the production of interleukin-18 .
9620656	0	interleukin-18	12,26	interferon-gamma	41,57	interleukin-18	interferon-gamma	3606	3458	Gene	Gene	Overview|nmod|START_ENTITY Overview|dep|an an|dep|factor factor|amod|END_ENTITY	Overview of interleukin-18 : more than an interferon-gamma inducing factor .
15735988	0	interleukin-18	18,32	interleukin-1	74,87	interleukin-18	interleukin-1	3606	3552	Gene	Gene	receptor|amod|START_ENTITY Concentration|nmod|receptor Concentration|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Concentration of interleukin-18 , interleukin-1beta , soluble receptor for interleukin-1 -LRB- sIL-1RII -RRB- and C-reactive_protein in patients with neuroborreliosis -RSB- .
9877452	0	interleukin-18	11,25	interleukin-1	152,165	interleukin-18	interleukin-1	3606	3552	Gene	Gene	IL-1Rrp1|amod|START_ENTITY Binding|nmod|IL-1Rrp1 leads|nsubj|Binding leads|xcomp|activation activation|advcl|signaling signaling|xcomp|similar similar|nmod|those those|acl|used used|advcl|END_ENTITY	Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1 .
9877452	0	interleukin-18	11,25	interleukin-1	33,46	interleukin-18	interleukin-1	3606	3552	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1Rrp1 leads to activation of signaling pathways similar to those used by interleukin-1 .
10048765	0	interleukin-18	114,128	interleukin-18	27,41	interleukin-18	interleukin-18	16173(Tax:10090)	16173(Tax:10090)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of cDNA for canine interleukin-18 and canine interleukin-1beta_converting_enzyme and expression of canine interleukin-18 .
10048765	0	interleukin-18	27,41	interleukin-18	114,128	interleukin-18	interleukin-18	16173(Tax:10090)	16173(Tax:10090)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of cDNA for canine interleukin-18 and canine interleukin-1beta_converting_enzyme and expression of canine interleukin-18 .
12632414	0	interleukin-18	108,122	interleukin-18	65,79	interleukin-18	interleukin-18	3606	3606	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Heterogeneity of response of rheumatoid synovium cell subsets to interleukin-18 in relation to differential interleukin-18 receptor expression .
12632414	0	interleukin-18	65,79	interleukin-18	108,122	interleukin-18	interleukin-18	3606	3606	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Heterogeneity of response of rheumatoid synovium cell subsets to interleukin-18 in relation to differential interleukin-18 receptor expression .
20422882	0	interleukin-18	7,21	interleukin-18_binding_protein	22,52	interleukin-18	interleukin-18 binding protein	3606	10068	Gene	Gene	ratio|dep|START_ENTITY ratio|amod|END_ENTITY	Plasma interleukin-18 / interleukin-18_binding_protein ratio in Chinese with NAFLD .
12571842	0	interleukin-18	15,29	interleukin-1beta	70,87	interleukin-18	interleukin-1beta	3606	3553	Gene	Gene	expression|amod|START_ENTITY Association|nmod|expression Association|nmod|END_ENTITY	Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor_necrosis_factor_alpha in knee synovial tissue of patients with rheumatoid_arthritis .
15735988	0	interleukin-18	18,32	interleukin-1beta	34,51	interleukin-18	interleukin-1beta	3606	3553	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	-LSB- Concentration of interleukin-18 , interleukin-1beta , soluble receptor for interleukin-1 -LRB- sIL-1RII -RRB- and C-reactive_protein in patients with neuroborreliosis -RSB- .
24531563	0	interleukin-18	24,38	vascular_endothelial_growth_factor	53,87	interleukin-18	vascular endothelial growth factor	3606	7422	Gene	Gene	intravitreous|amod|START_ENTITY correlated|nsubj|intravitreous correlated|xcomp|END_ENTITY	Increased intravitreous interleukin-18 correlated to vascular_endothelial_growth_factor in patients with active proliferative_diabetic_retinopathy .
12626794	0	interleukin-18_binding_protein	39,69	Interferon-gamma	0,16	interleukin-18 binding protein	Interferon-gamma	10068	3458	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interferon-gamma induces expression of interleukin-18_binding_protein in fibroblast-like synoviocytes .
20422882	0	interleukin-18_binding_protein	22,52	interleukin-18	7,21	interleukin-18 binding protein	interleukin-18	10068	3606	Gene	Gene	ratio|amod|START_ENTITY ratio|dep|END_ENTITY	Plasma interleukin-18 / interleukin-18_binding_protein ratio in Chinese with NAFLD .
9110153	0	interleukin-1_alpha	26,45	Growth_hormone	0,14	interleukin-1 alpha	Growth hormone	16175(Tax:10090)	14599(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Growth_hormone release of interleukin-1_alpha , interferon-gamma and interleukin-4 from murine splenocytes stimulated with staphylococcal protein A , toxic_shock_syndrome toxin-1 and streptococcal lysin S .
1954872	0	interleukin-1_alpha	27,46	Interleukin-1_beta	0,18	interleukin-1 alpha	Interleukin-1 beta	3552	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_beta induces interleukin-1_alpha messenger ribonucleic acid expression in primary cultures of Leydig cells .
2506855	0	interleukin-1_alpha	39,58	Interleukin-1_beta	0,18	interleukin-1 alpha	Interleukin-1 beta	3552	3553	Gene	Gene	potent|advcl|START_ENTITY potent|nsubj|END_ENTITY	Interleukin-1_beta is more potent than interleukin-1_alpha in suppressing follicle-stimulating hormone-induced differentiation_of_ovarian_granulosa cells .
15863387	0	interleukin-1_alpha	6,25	Sp1	58,61	interleukin-1 alpha	Sp1	3552	6667	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Human interleukin-1_alpha gene expression is regulated by Sp1 and a transcriptional repressor .
8331299	0	interleukin-1_alpha	36,55	Tumor_necrosis_factor-alpha	0,27	interleukin-1 alpha	Tumor necrosis factor-alpha	3552	7124	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-1_alpha and interleukin-1 receptor antagonist production by cultured human keratinocytes .
7927949	0	interleukin-1_alpha	29,48	apolipoprotein_D	52,68	interleukin-1 alpha	apolipoprotein D	3552	347	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Potent stimulatory effect of interleukin-1_alpha on apolipoprotein_D and gross_cystic_disease_fluid_protein-15 expression in human breast-cancer cells .
15079806	0	interleukin-1_alpha	72,91	apolipoprotein_E	54,70	interleukin-1 alpha	apolipoprotein E	3552	348	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	-LSB- Analysis on association between the polymorphisms in apolipoprotein_E , interleukin-1_alpha genes and Alzheimer 's _ disease in Chengdu area -RSB- .
9602296	0	interleukin-1_alpha	18,37	colony-stimulating_factor-1	41,68	interleukin-1 alpha	colony-stimulating factor-1	24493(Tax:10116)	78965(Tax:10116)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	In vivo effect of interleukin-1_alpha on colony-stimulating_factor-1 gene expression in the dental follicle of the rat molar .
8163473	0	interleukin-1_alpha	33,52	cyclooxygenase-2	13,29	interleukin-1 alpha	cyclooxygenase-2	3552	5743	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 by interleukin-1_alpha .
3139106	0	interleukin-1_alpha	14,33	granulocyte-macrophage_colony-stimulating_factor	123,171	interleukin-1 alpha	granulocyte-macrophage colony-stimulating factor	3552	1437	Gene	Gene	Production|nmod|START_ENTITY Production|acl|stimulated stimulated|nmod|END_ENTITY	Production of interleukin-1_alpha , interleukin-1_beta and tumor_necrosis_factor by human mononuclear cells stimulated with granulocyte-macrophage_colony-stimulating_factor .
1280478	0	interleukin-1_alpha	99,118	granulocyte_colony-stimulating_factor	46,83	interleukin-1 alpha	granulocyte colony-stimulating factor	3552	1440	Gene	Gene	synthesize|nmod|START_ENTITY synthesize|dobj|END_ENTITY	Human arterial smooth_muscle_cells synthesize granulocyte_colony-stimulating_factor in response to interleukin-1_alpha and tumor_necrosis_factor-alpha .
2100277	0	interleukin-1_alpha	14,33	growth_hormone	134,148	interleukin-1 alpha	growth hormone	3552	2688	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|cells cells|nmod|degree degree|nmod|deficiency deficiency|amod|END_ENTITY	Production of interleukin-1_alpha and interleukin-2 by mononuclear cells from children with growth delay in relation to the degree of growth_hormone deficiency : effects of substitutive treatment .
1661739	0	interleukin-1_alpha	74,93	interleukin-1_beta	13,31	interleukin-1 alpha	interleukin-1 beta	3552	3553	Gene	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|nsubj|Induction Induction|nmod|production production|amod|END_ENTITY	Induction of interleukin-1_beta production in human dermal fibroblasts by interleukin-1_alpha and tumor_necrosis_factor-alpha .
2044220	0	interleukin-1_alpha	14,33	interleukin-1_beta	35,53	interleukin-1 alpha	interleukin-1 beta	3552	3553	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of interleukin-1_alpha , interleukin-1_beta and interleukin-6 in chronic B_lymphocytic_leukaemia -LRB- B-CLL -RRB- cells from patients at different stages of disease progression .
7614991	0	interleukin-1_alpha	43,62	interleukin-1_beta	156,174	interleukin-1 alpha	interleukin-1 beta	3552	3553	Gene	Gene	production|nmod|START_ENTITY production|dep|evidence evidence|nmod|levels levels|amod|END_ENTITY	Enhanced production of biologically active interleukin-1_alpha and interleukin-1_beta by psoriatic epidermal cells ex vivo : evidence of increased cytosolic interleukin-1_beta levels and facilitated interleukin-1 release .
8188271	0	interleukin-1_alpha	52,71	interleukin-1_beta	73,91	interleukin-1 alpha	interleukin-1 beta	3552	3553	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	A physical map of the region encompassing the human interleukin-1_alpha , interleukin-1_beta , and interleukin-1 receptor antagonist genes .
8195120	0	interleukin-1_alpha	46,65	interleukin-1_beta	67,85	interleukin-1 alpha	interleukin-1 beta	3552	3553	Gene	Gene	transcripts|amod|START_ENTITY transcripts|amod|END_ENTITY	DNA damaging agents increase the stability of interleukin-1_alpha , interleukin-1_beta , and interleukin-6 transcripts and the production of the relative proteins .
8482109	0	interleukin-1_alpha	128,147	interleukin-1_beta	41,59	interleukin-1 alpha	interleukin-1 beta	3552	3553	Gene	Gene	response|nmod|START_ENTITY produce|nmod|response produce|xcomp|END_ENTITY	Retinal pigment epithelial cells produce interleukin-1_beta and granulocyte-macrophage_colony-stimulating_factor in response to interleukin-1_alpha .
18434191	0	interleukin-1_alpha	24,43	interleukin-6	56,69	interleukin-1 alpha	interleukin-6	3552	3569	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|synthesis synthesis|amod|END_ENTITY	Differential effects of interleukin-1_alpha and beta on interleukin-6 and chemokine synthesis in neurones .
17013473	0	interleukin-1_alpha	24,43	interleukin-6_and_tumor_necrosis_factor-alpha	45,90	interleukin-1 alpha	interleukin-6 and tumor necrosis factor-alpha	3552	3569;7124	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of interleukin-1_alpha , interleukin-6_and_tumor_necrosis_factor-alpha in neonatal_sepsis and meningitis .
9530111	0	interleukin-1_alpha	67,86	p42mapk	14,21	interleukin-1 alpha	p42mapk	3552	5594	Gene	Gene	endothelial|nmod|START_ENTITY endothelial|nsubj|Activation Activation|nmod|END_ENTITY	Activation of p42mapk in human umbilical vein endothelial cells by interleukin-1_alpha and tumor_necrosis_factor-alpha .
9420870	0	interleukin-1_alpha	24,43	tumor_necrosis_factor-alpha	45,72	interleukin-1 alpha	tumor necrosis factor-alpha	3552	7124	Gene	Gene	hydrocortisone|compound|START_ENTITY hydrocortisone|dep|END_ENTITY	Differential effects of interleukin-1_alpha , tumor_necrosis_factor-alpha , indomethacin , hydrocortisone , and macrophage co-culture on the proliferation of human fibroblasts and peritoneal mesothelial cells .
9751191	0	interleukin-1_alpha	77,96	tumor_necrosis_factor-alpha	48,75	interleukin-1 alpha	tumor necrosis factor-alpha	16175(Tax:10090)	21926(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Cellular localization and temporal elevation of tumor_necrosis_factor-alpha , interleukin-1_alpha , and transforming_growth_factor-beta_1 mRNA in hippocampal_injury response induced by trimethyltin .
1384490	0	interleukin-1_alpha	29,48	urokinase-type_plasminogen_activator	74,110	interleukin-1 alpha	urokinase-type plasminogen activator	3552	5328	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Gamma-interferon counteracts interleukin-1_alpha stimulated expression of urokinase-type_plasminogen_activator in human endothelial cells in vitro .
8360185	0	interleukin-1_and_dexamethasone	56,87	Protease_nexin-1	0,16	interleukin-1 and dexamethasone	Protease nexin-1	3552	5270	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Protease_nexin-1 , a thrombin inhibitor , is regulated by interleukin-1_and_dexamethasone in normal human fibroblasts .
9496264	0	interleukin-1_and_dexamethasone	10,41	interleukin-6	45,58	interleukin-1 and dexamethasone	interleukin-6	3552	3569	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effect of interleukin-1_and_dexamethasone on interleukin-6 production and growth in human meningiomas .
15629451	0	interleukin-1_and_interferon-gamma	106,140	hepatocyte_growth_factor	25,49	interleukin-1 and interferon-gamma	hepatocyte growth factor	3552;3458	3082	Gene	Gene	fibroblasts|nmod|START_ENTITY fibroblasts|nsubj|induction induction|nmod|END_ENTITY	Synergistic induction of hepatocyte_growth_factor in human skin fibroblasts by the inflammatory cytokines interleukin-1_and_interferon-gamma .
7783752	0	interleukin-1_and_interferon-gamma	101,135	interleukin-1_beta	81,99	interleukin-1 and interferon-gamma	interleukin-1 beta	15978(Tax:10090)	16176(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1_beta , interleukin-1_and_interferon-gamma mRNA in the lymph nodes of lupus-prone mice .
1700731	0	interleukin-1_and_tumor_necrosis_factor	147,186	GM-CSF	116,122	interleukin-1 and tumor necrosis factor	GM-CSF	3552;7124	1437	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Cytokine regulation of colony-stimulating factor production in cultured human synovial fibroblasts : I. Induction of GM-CSF and G-CSF production by interleukin-1_and_tumor_necrosis_factor .
2195296	0	interleukin-1_and_tumor_necrosis_factor	10,49	cachectin	50,59	interleukin-1 and tumor necrosis factor	cachectin	103694380	24835(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of interleukin-1_and_tumor_necrosis_factor / cachectin on glucose turnover in the rat .
20424162	0	interleukin-1_beta	85,103	CHOP	65,69	interleukin-1 beta	CHOP	3553	1649	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation of CCAAT/enhancer-binding _ protein_homologous_protein -LRB- CHOP -RRB- expression by interleukin-1_beta in pancreatic beta cells .
9345309	0	interleukin-1_beta	24,42	CYP_1A1	111,118	interleukin-1 beta	CYP 1A1	100008990(Tax:9986)	100328613(Tax:9986)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Differential effects of interleukin-1_beta , interleukin-2 , and interferon-gamma on the inducible expression of CYP_1A1 and CYP_1A2 in cultured rabbit hepatocytes .
12839952	0	interleukin-1_beta	36,54	Cyclooxygenase-2	0,16	interleukin-1 beta	Cyclooxygenase-2	3553	5743	Gene	Gene	up-regulated|advcl|START_ENTITY up-regulated|nsubj|END_ENTITY	Cyclooxygenase-2 is up-regulated by interleukin-1_beta in human colorectal_cancer cells via multiple signaling pathways .
9352015	0	interleukin-1_beta	14,32	EP1	96,99	interleukin-1 beta	EP1	3553	5731	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	The effect of interleukin-1_beta and interleukin-4 on the expression of prostaglandin receptors EP1 and EP3 in amnion WISH cells .
8218947	0	interleukin-1_beta	70,88	Fc_receptors	13,25	interleukin-1 beta	Fc receptors	16176(Tax:10090)	109615(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of Fc_receptors on murine macrophages and leukemic cells by interleukin-1_beta .
8955505	0	interleukin-1_beta	143,161	G-CSF	123,128	interleukin-1 beta	G-CSF	3553	1440	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Human endometrial expression of granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- and its receptor , stimulation of endometrial G-CSF production by interleukin-1_beta , and G-CSF inhibition of choriocarcinoma cell proliferation .
1353022	0	interleukin-1_beta	33,51	IL-1_beta	53,62	interleukin-1 beta	IL-1 beta	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A TaqI polymorphism in the human interleukin-1_beta -LRB- IL-1_beta -RRB- gene correlates with IL-1_beta secretion in vitro .
1387412	0	interleukin-1_beta	71,89	IL-1_beta	91,100	interleukin-1 beta	IL-1 beta	3553	3553	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Human dermal fibroblast interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- and interleukin-1_beta -LRB- IL-1_beta -RRB- mRNA and protein are co-stimulated by phorbol_ester : implication for a homeostatic mechanism .
1596574	0	interleukin-1_beta	58,76	IL-1_beta	78,87	interleukin-1 beta	IL-1 beta	3553	3553	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- and interleukin-1_beta -LRB- IL-1_beta -RRB- messenger RNA -LRB- mRNA -RRB- expression in HL-60 leukemia cells by pentoxifylline and dexamethasone : dissociation of acivicin-induced TNF-alpha and IL-1_beta mRNA expression from acivicin-induced monocytoid differentiation .
7684503	0	interleukin-1_beta	18,36	IL-1_beta	38,47	interleukin-1 beta	IL-1 beta	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of the interleukin-1_beta -LRB- IL-1_beta -RRB- gene by mycobacterial components and lipopolysaccharide is mediated by two nuclear_factor-IL6 motifs .
9187965	0	interleukin-1_beta	111,129	IL-1_beta	131,140	interleukin-1 beta	IL-1 beta	3553	3553	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differential effects of cell density on 5-lipoxygenase -LRB- 5-LO -RRB- , five-lipoxygenase-activating_protein -LRB- FLAP -RRB- and interleukin-1_beta -LRB- IL-1_beta -RRB- expression in human neutrophils .
9292778	0	interleukin-1_beta	21,39	IL-1_beta	41,50	interleukin-1 beta	IL-1 beta	16176(Tax:10090)	16176(Tax:10090)	Gene	Gene	pattern|nmod|START_ENTITY pattern|dep|END_ENTITY	Different pattern of interleukin-1_beta - -LRB- IL-1_beta -RRB- , interleukin-1_receptor_antagonist - -LRB- IL-1ra -RRB- and interleukin-1_receptor_type_I - -LRB- IL-1R_tI -RRB- mRNA-expression in single preimplantation mouse embryos at various developmental stages .
21424904	0	interleukin-1_beta	32,50	IL-1b	52,57	interleukin-1 beta	IL-1b	3553	3553	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Association between circulating interleukin-1_beta -LRB- IL-1b -RRB- levels and IL-1b C-511T polymorphism with cervical_cancer risk in Egyptian women .
9468219	0	interleukin-1_beta	82,100	IL-1beta	102,110	interleukin-1 beta	IL-1beta	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a second transcription initiation element -LRB- STIE -RRB- in the human interleukin-1_beta -LRB- IL-1beta -RRB- gene .
9292778	0	interleukin-1_beta	21,39	IL-1ra	89,95	interleukin-1 beta	IL-1ra	16176(Tax:10090)	16181(Tax:10090)	Gene	Gene	pattern|nmod|START_ENTITY pattern|dep|END_ENTITY	Different pattern of interleukin-1_beta - -LRB- IL-1_beta -RRB- , interleukin-1_receptor_antagonist - -LRB- IL-1ra -RRB- and interleukin-1_receptor_type_I - -LRB- IL-1R_tI -RRB- mRNA-expression in single preimplantation mouse embryos at various developmental stages .
7473344	0	interleukin-1_beta	44,62	Immediate-early	0,15	interleukin-1 beta	Immediate-early	16176(Tax:10090)	16476(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY induction|nmod|gene induction|amod|END_ENTITY	Immediate-early , transient induction of the interleukin-1_beta gene in mouse spleen macrophages by ionizing radiation .
8725537	0	interleukin-1_beta	21,39	Interleukin-1_alpha	0,19	interleukin-1 beta	Interleukin-1 alpha	3553	3552	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	Interleukin-1_alpha , interleukin-1_beta and interleukin-8 gene expression in human aural_cholesteatomas .
16845798	0	interleukin-1_beta	71,89	Interleukin-6	0,13	interleukin-1 beta	Interleukin-6	3553	3569	Gene	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced fibrosus|nmod|apoptosis protects|ccomp|fibrosus protects|nsubj|END_ENTITY	Interleukin-6 protects annulus fibrosus cell from apoptosis induced by interleukin-1_beta in vitro .
1715456	0	interleukin-1_beta	97,115	Interleukin-6	0,13	interleukin-1 beta	Interleukin-6	3553	3569	Gene	Gene	cells|nmod|START_ENTITY proliferation|nmod|cells stimulates|dobj|proliferation stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates proliferation of cultured vascular smooth muscle cells independently of interleukin-1_beta .
23566695	0	interleukin-1_beta	15,33	Interleukin-6	0,13	interleukin-1 beta	Interleukin-6	3553	3569	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Interleukin-6 , interleukin-1_beta and interleukin-1_receptor_antagonist levels in epileptic_seizures .
8041488	0	interleukin-1_beta	98,116	Interleukin-6	0,13	interleukin-1 beta	Interleukin-6	3553	3569	Gene	Gene	interactions|nmod|START_ENTITY production|dep|interactions production|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- production and cell growth of cultured human ameningiomas : - interactions with interleukin-1_beta -LRB- IL-1_beta -RRB- and interleukin-4 -LRB- IL-4 -RRB- in vitro .
12842905	0	interleukin-1_beta	37,55	MUC8	13,17	interleukin-1 beta	MUC8	3553	100129528	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of MUC8 gene expression by interleukin-1_beta is mediated by a sequential ERK MAPK/RSK1/CREB cascade pathway in human airway epithelial cells .
7629057	0	interleukin-1_beta	24,42	NF-kappa_B	75,85	interleukin-1 beta	NF-kappa B	3553	4790	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Low affinity binding of interleukin-1_beta and intracellular signaling via NF-kappa_B identify Fit-1 as a distant member of the interleukin-1 receptor family .
9798528	0	interleukin-1_beta	96,114	NF-kappa_B	15,25	interleukin-1 beta	NF-kappa B	24494(Tax:10116)	4790	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Nuclear factor NF-kappa_B in myocardium : developmental expression of subunits and activation by interleukin-1_beta in cardiac myocytes in vitro .
9681388	0	interleukin-1_beta	53,71	NFkappaB	86,94	interleukin-1 beta	NFkappaB	16176(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Interleukin-1-mediated febrile responses in mice and interleukin-1_beta activation of NFkappaB in mouse primary astrocytes , involves the interleukin-1_receptor_accessory_protein .
2154976	0	interleukin-1_beta	59,77	Tumor_necrosis_factor-alpha	0,27	interleukin-1 beta	Tumor necrosis factor-alpha	3553	7124	Gene	Gene	steroidogenesis|amod|START_ENTITY effects|nmod|steroidogenesis enhances|dobj|effects enhances|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha enhances inhibitory effects of interleukin-1_beta on Leydig cell steroidogenesis .
2542010	0	interleukin-1_beta	73,91	Tumor_necrosis_factor-alpha	0,27	interleukin-1 beta	Tumor necrosis factor-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	comparison|nmod|START_ENTITY secretagogue|dep|comparison secretagogue|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha is a potent ACTH secretagogue : comparison to interleukin-1_beta .
8604710	0	interleukin-1_beta	29,47	Tumor_necrosis_factor-alpha	0,27	interleukin-1 beta	Tumor necrosis factor-alpha	3553	7124	Gene	Gene	receptor|amod|START_ENTITY antagonist|nsubj|receptor antagonist|advmod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-1_beta , and interleukin-1 receptor antagonist in dialysate and serum from patients on continuous ambulatory peritoneal dialysis .
8608789	0	interleukin-1_beta	37,55	Tumor_necrosis_factor-alpha	0,27	interleukin-1 beta	Tumor necrosis factor-alpha	24494(Tax:10116)	24835(Tax:10116)	Gene	Gene	prevents|xcomp|START_ENTITY prevents|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha prevents interleukin-1_beta from augmenting capsaicin-induced vasodilatation in the rat skin .
9377887	0	interleukin-1_beta	29,47	Tumor_necrosis_factor-alpha	0,27	interleukin-1 beta	Tumor necrosis factor-alpha	3553	7124	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-1_beta , and interleukin-6 concentrations in cerebrospinal fluid predict ventriculoperitoneal_shunt_infection .
16197804	0	interleukin-1_beta	29,47	Tumor_necrosis_factor_alpha	0,27	interleukin-1 beta	Tumor necrosis factor alpha	3553	7124	Gene	Gene	molecules|amod|START_ENTITY END_ENTITY|appos|molecules	Tumor_necrosis_factor_alpha , interleukin-1_beta , interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge .
8222965	0	interleukin-1_beta	11,29	alkaline_phosphatase	51,71	interleukin-1 beta	alkaline phosphatase	3553	250	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	-LSB- Effect of interleukin-1_beta on liver/bone/kidney alkaline_phosphatase mRNA level of fibroblastic cells derived from human periodontal ligament -RSB- .
7834189	0	interleukin-1_beta	82,100	bradykinin_B1_receptor	56,78	interleukin-1 beta	bradykinin B1 receptor	100008990(Tax:9986)	100009198(Tax:9986)	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	Up-regulation of -LSB- 3H -RSB- - des-Arg10-kallidin binding to the bradykinin_B1_receptor by interleukin-1_beta in isolated smooth muscle cells : correlation with B1 agonist-induced PGI2 production .
2176623	0	interleukin-1_beta	10,28	cathepsin_B	50,61	interleukin-1 beta	cathepsin B	100008990(Tax:9986)	100101593(Tax:9986)	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of interleukin-1_beta on the production of cathepsin_B by rabbit articular chondrocytes .
10810453	0	interleukin-1_beta	70,88	cyclooxygenase-2	27,43	interleukin-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	IL-1_beta|amod|START_ENTITY stability|nmod|IL-1_beta stability|amod|END_ENTITY	Differential regulation of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA stability by interleukin-1_beta -LRB- IL-1_beta -RRB- and tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human in vitro differentiated macrophages .
11352510	0	interleukin-1_beta	124,142	cyclooxygenase-2	27,43	interleukin-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	primed|advcl|START_ENTITY fibroblasts|acl|primed mobilization|nmod|fibroblasts expression|nmod|mobilization expression|amod|END_ENTITY	Bradykinin induces a rapid cyclooxygenase-2 mRNA expression via Ca2 + mobilization in human gingival fibroblasts primed with interleukin-1_beta .
18571585	0	interleukin-1_beta	25,43	cyclooxygenase-2	114,130	interleukin-1 beta	cyclooxygenase-2	3553	5743	Gene	Gene	chemoresistance|amod|START_ENTITY cell-derived|dobj|chemoresistance cell-derived|nmod|upregulation upregulation|nmod|END_ENTITY	Mononuclear cell-derived interleukin-1_beta confers chemoresistance in pancreatic_cancer cells by upregulation of cyclooxygenase-2 .
8891309	0	interleukin-1_beta	101,119	cyclooxygenase-2	55,71	interleukin-1 beta	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY express|nmod|synthesis express|dobj|mRNA mRNA|amod|END_ENTITY	Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1_beta : a possible site of prostaglandin synthesis responsible for fever .
9089489	0	interleukin-1_beta	23,41	decorin	45,52	interleukin-1 beta	decorin	3553	1634	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of recombinant interleukin-1_beta on decorin gene expression in human periodontal ligament fibroblast and its possible transcriptional regulation .
8709978	0	interleukin-1_beta	45,63	early_growth_response-1	13,36	interleukin-1 beta	early growth response-1	3553	1958	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Induction of early_growth_response-1 gene by interleukin-1_beta and tumor_necrosis_factor-alpha in normal human bone marrow stromal an osteoblastic cells : regulation by a protein kinase C inhibitor .
8454621	0	interleukin-1_beta	18,36	elastin	50,57	interleukin-1 beta	elastin	3553	2006	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Human recombinant interleukin-1_beta up-regulates elastin gene expression in dermal fibroblasts .
8881517	0	interleukin-1_beta	66,84	fibroblast_growth_factor-2	12,38	interleukin-1 beta	fibroblast growth factor-2	396565(Tax:9823)	397643(Tax:9823)	Gene	Gene	role|nmod|START_ENTITY role|nmod|effects effects|amod|END_ENTITY	The role of fibroblast_growth_factor-2 in the vascular effects of interleukin-1_beta in porcine coronary arteries in vivo .
8982099	0	interleukin-1_beta	117,135	gastrin-releasing_peptide	24,49	interleukin-1 beta	gastrin-releasing peptide	3553	2922	Gene	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Differential effects of gastrin-releasing_peptide , neuropeptide_Y , somatostatin and vasoactive_intestinal_peptide on interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha production by whole blood cells from healthy young and old subjects .
1641070	0	interleukin-1_beta	58,76	growth_hormone	30,44	interleukin-1 beta	growth hormone	24494(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Stimulation and inhibition of growth_hormone secretion by interleukin-1_beta : the involvement of growth_hormone-releasing hormone .
19180878	0	interleukin-1_beta	10,28	growth_hormone	32,46	interleukin-1 beta	growth hormone	24494(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Effect of interleukin-1_beta on growth_hormone gene expression and its possible molecular mechanism in rat MtT/S somatotroph cells .
2125218	0	interleukin-1_beta	49,67	insulin	10,17	interleukin-1 beta	insulin	3553	3630	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibited insulin secretion by recombinant human interleukin-1_beta in adrenalectomized rats : involvement of prostaglandin .
2521822	0	interleukin-1_beta	108,126	insulin	48,55	interleukin-1 beta	insulin	3553	3630	Gene	Gene	exposed|nmod|START_ENTITY islets|acl|exposed causing|nmod|islets causing|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1_beta indicate a perturbation in the mitochondrial function .
8655918	0	interleukin-1_beta	21,39	insulin	51,58	interleukin-1 beta	insulin	3553	3630	Gene	Gene	effects|amod|START_ENTITY dependence|nmod|effects dependence|nmod|secretion secretion|compound|END_ENTITY	The pH dependence of interleukin-1_beta effects on insulin secretion in HIT cells .
1661739	0	interleukin-1_beta	13,31	interleukin-1_alpha	74,93	interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	production|amod|START_ENTITY Induction|nmod|production fibroblasts|nsubj|Induction fibroblasts|nmod|END_ENTITY	Induction of interleukin-1_beta production in human dermal fibroblasts by interleukin-1_alpha and tumor_necrosis_factor-alpha .
2044220	0	interleukin-1_beta	35,53	interleukin-1_alpha	14,33	interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of interleukin-1_alpha , interleukin-1_beta and interleukin-6 in chronic B_lymphocytic_leukaemia -LRB- B-CLL -RRB- cells from patients at different stages of disease progression .
7614991	0	interleukin-1_beta	156,174	interleukin-1_alpha	43,62	interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	levels|amod|START_ENTITY evidence|nmod|levels production|dep|evidence production|nmod|END_ENTITY	Enhanced production of biologically active interleukin-1_alpha and interleukin-1_beta by psoriatic epidermal cells ex vivo : evidence of increased cytosolic interleukin-1_beta levels and facilitated interleukin-1 release .
8188271	0	interleukin-1_beta	73,91	interleukin-1_alpha	52,71	interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	A physical map of the region encompassing the human interleukin-1_alpha , interleukin-1_beta , and interleukin-1 receptor antagonist genes .
8195120	0	interleukin-1_beta	67,85	interleukin-1_alpha	46,65	interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	transcripts|amod|START_ENTITY transcripts|amod|END_ENTITY	DNA damaging agents increase the stability of interleukin-1_alpha , interleukin-1_beta , and interleukin-6 transcripts and the production of the relative proteins .
8482109	0	interleukin-1_beta	41,59	interleukin-1_alpha	128,147	interleukin-1 beta	interleukin-1 alpha	3553	3552	Gene	Gene	produce|xcomp|START_ENTITY produce|nmod|response response|nmod|END_ENTITY	Retinal pigment epithelial cells produce interleukin-1_beta and granulocyte-macrophage_colony-stimulating_factor in response to interleukin-1_alpha .
7783752	0	interleukin-1_beta	81,99	interleukin-1_and_interferon-gamma	101,135	interleukin-1 beta	interleukin-1 and interferon-gamma	16176(Tax:10090)	15978(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1_beta , interleukin-1_and_interferon-gamma mRNA in the lymph nodes of lupus-prone mice .
7922783	0	interleukin-1_beta	86,104	interleukin-1_receptor_antagonist	18,51	interleukin-1 beta	interleukin-1 receptor antagonist	3553	3557	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|blocks blocks|amod|END_ENTITY	Human recombinant interleukin-1_receptor_antagonist blocks bone resorption induced by interleukin-1_beta but not interleukin-1_alpha .
16474945	0	interleukin-1_beta	11,29	interleukin-6	31,44	interleukin-1 beta	interleukin-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	fields|amod|START_ENTITY fields|amod|END_ENTITY	Effects of interleukin-1_beta , interleukin-6 , and tumor_necrosis_factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats .
7595543	0	interleukin-1_beta	42,60	interleukin-6	87,100	interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	essential|advcl|START_ENTITY essential|dep|stimulated stimulated|dobj|production production|nmod|cells cells|amod|END_ENTITY	Tyrosine_kinase activity is essential for interleukin-1_beta -- stimulated production of interleukin-6 in U373 human astrocytoma cells .
7877083	0	interleukin-1_beta	120,138	interleukin-6	26,39	interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	stimulated|nmod|START_ENTITY human_gingival_fibroblasts|acl|stimulated inhibits|nmod|human_gingival_fibroblasts inhibits|dobj|release release|amod|END_ENTITY	Prostaglandin_E2 inhibits interleukin-6 release but not its transcription in human_gingival_fibroblasts stimulated with interleukin-1_beta or tumor_necrosis_factor-alpha .
7987845	0	interleukin-1_beta	9,27	interleukin-6	28,41	interleukin-1 beta	interleukin-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	treatment|dep|START_ENTITY treatment|amod|END_ENTITY	Combined interleukin-1_beta / interleukin-6 treatment in mice : synergistic myelostimulatory activity and myelorestorative effect after cyclophosphamide-induced myelosuppression .
8307455	0	interleukin-1_beta	38,56	interleukin-6	23,36	interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	C-reactive_protein|amod|START_ENTITY C-reactive_protein|amod|END_ENTITY	Interrelations between interleukin-6 , interleukin-1_beta , plasma C-reactive_protein values , and in vitro C-reactive_protein generation in patients with inflammatory_bowel_disease .
8841895	0	interleukin-1_beta	29,47	interleukin-6	56,69	interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Prostaglandin_E2 potentiates interleukin-1_beta induced interleukin-6 production by human_gingival_fibroblasts .
9369827	0	interleukin-1_beta	70,88	interleukin-6	26,39	interleukin-1 beta	interleukin-6	3553	3569	Gene	Gene	tumor_necrosis_factor-alpha|nummod|START_ENTITY tumor_necrosis_factor-alpha|nummod|END_ENTITY	Amniotic fluid cytokines -LRB- interleukin-6 , tumor_necrosis_factor-alpha , interleukin-1_beta , and interleukin-8 -RRB- and the risk for the development of bronchopulmonary_dysplasia .
7880977	0	interleukin-1_beta	26,44	interleukin-6_and_tumor_necrosis_factor-alpha	46,91	interleukin-1 beta	interleukin-6 and tumor necrosis factor-alpha	3553	3569;7124	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Cellular localisations of interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha mRNA in a parasitic granulomatous_disease_of_the_liver , alveolar_echinococcosis .
8982099	0	interleukin-1_beta	117,135	interleukin-6_and_tumor_necrosis_factor-alpha	137,182	interleukin-1 beta	interleukin-6 and tumor necrosis factor-alpha	3553	3569;7124	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Differential effects of gastrin-releasing_peptide , neuropeptide_Y , somatostatin and vasoactive_intestinal_peptide on interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha production by whole blood cells from healthy young and old subjects .
8216423	0	interleukin-1_beta	22,40	interleukin-8	76,89	interleukin-1 beta	interleukin-8	3553	3576	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Synergistic effect of interleukin-1_beta and tumor_necrosis_factor_alpha on interleukin-8 gene expression in synovial fibroblasts .
9203094	0	interleukin-1_beta	11,29	matrix_metalloproteinase-3	33,59	interleukin-1 beta	matrix metalloproteinase-3	3553	4314	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Effects of interleukin-1_beta on matrix_metalloproteinase-3 levels in human periodontal ligament cells .
1333537	0	interleukin-1_beta	53,71	nerve_growth_factor	14,33	interleukin-1 beta	nerve growth factor	3553	4803	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Mechanisms of nerve_growth_factor mRNA regulation by interleukin-1_beta in hippocampal cultures : role of second messengers .
7582555	0	interleukin-1_beta	16,34	nerve_growth_factor	75,94	interleukin-1 beta	nerve growth factor	3553	4803	Gene	Gene	START_ENTITY|nmod|increase increase|nmod|END_ENTITY	Contribution of interleukin-1_beta to the inflammation-induced increase in nerve_growth_factor levels and inflammatory_hyperalgesia .
8056439	0	interleukin-1_beta	134,152	nerve_growth_factor	81,100	interleukin-1 beta	nerve growth factor	3553	310738(Tax:10116)	Gene	Gene	stimulation|acl|START_ENTITY additive|nsubj|stimulation system|parataxis|additive system|nmod|study study|nmod|regulation regulation|compound|END_ENTITY	The immortalized astroglial cell line RC7 is a new model system for the study of nerve_growth_factor -LRB- NGF -RRB- regulation : stimulation by interleukin-1_beta and transforming_growth_factor-beta_1 is additive and affected differently by dibutyryl_cyclic_AMP .
1618301	0	interleukin-1_beta	37,55	phospholipase_A2	9,25	interleukin-1 beta	phospholipase A2	24494(Tax:10116)	151056	Gene	Gene	fibroblasts|amod|START_ENTITY induced|nmod|fibroblasts induced|nsubj|END_ENTITY	Group II phospholipase_A2 induced by interleukin-1_beta in cultured rat gingival fibroblasts .
8832976	0	interleukin-1_beta	86,104	phospholipase_A2	48,64	interleukin-1 beta	phospholipase A2	3553	151056	Gene	Gene	prostaglandin_E2|amod|START_ENTITY reduces|dobj|prostaglandin_E2 reduces|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of human synovial fibroblast 85 kDa phospholipase_A2 by antisense reduces interleukin-1_beta induced prostaglandin_E2 .
7488148	0	interleukin-1_beta	49,67	serotonin_transporter	24,45	interleukin-1 beta	serotonin transporter	3553	6532	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the human serotonin_transporter by interleukin-1_beta .
19435930	0	interleukin-1_beta	44,62	tristetraprolin	14,29	interleukin-1 beta	tristetraprolin	3553	7538	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of tristetraprolin expression by interleukin-1_beta and dexamethasone in human pulmonary epithelial cells : roles for nuclear factor-kappa B and p38_mitogen-activated_protein_kinase .
14611111	0	interleukin-1_beta	122,140	tumor_necrosis_factor-alpha	93,120	interleukin-1 beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	exposure|amod|START_ENTITY exposure|nmod|END_ENTITY	Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor_necrosis_factor-alpha , interleukin-1_beta and cholecystokinin-8 : the possible role of NGF in the inflammatory response .
1490727	0	interleukin-1_beta	87,105	tumor_necrosis_factor-alpha	48,75	interleukin-1 beta	tumor necrosis factor-alpha	16176(Tax:10090)	21926(Tax:10090)	Gene	Gene	release|advcl|START_ENTITY release|nsubj|down-regulation down-regulation|nmod|END_ENTITY	Indirect and selective down-regulation of serum tumor_necrosis_factor-alpha release by interleukin-1_beta .
2121675	0	interleukin-1_beta	38,56	tumor_necrosis_factor-alpha	101,128	interleukin-1 beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Antitumor effect of recombinant human interleukin-1_beta alone and in combination with natural human tumor_necrosis_factor-alpha .
8380885	0	interleukin-1_beta	43,61	tumor_necrosis_factor-alpha	14,41	interleukin-1 beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	_|dep|START_ENTITY expression|amod|_ expression|amod|END_ENTITY	Modulation of tumor_necrosis_factor-alpha , interleukin-1_beta , interleukin-6 , interleukin-8 , and granulocyte/macrophage _ colony-stimulating_factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand , triakontatetraneuropeptide : evidence for a role of prostaglandins .
8865966	0	interleukin-1_beta	106,124	tumor_necrosis_factor-alpha	77,104	interleukin-1 beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	interleukin-10|amod|START_ENTITY END_ENTITY|appos|interleukin-10	Regulation of human monocyte functions by acute ethanol treatment : decreased tumor_necrosis_factor-alpha , interleukin-1_beta and elevated interleukin-10 , and transforming_growth_factor-beta production .
9051688	0	interleukin-1_beta	44,62	tumor_necrosis_factor-alpha	15,42	interleukin-1 beta	tumor necrosis factor-alpha	100008990(Tax:9986)	100009088(Tax:9986)	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Involvement of tumor_necrosis_factor-alpha , interleukin-1_beta , interleukin-8 , and interleukin-1 receptor antagonist in acute_lung_injury caused by local Shwartzman reaction .
11950481	0	interleukin-1_beta	37,55	tumor_necrosis_factor_alpha	211,238	interleukin-1 beta	tumor necrosis factor alpha	3553	7124	Gene	Gene	levels|acl|START_ENTITY ribonucleic_acid|dobj|levels ribonucleic_acid|nmod|segment segment|acl|increased increased|advcl|remained remained|nsubj|those those|nmod|END_ENTITY	Messenger ribonucleic_acid levels of interleukin-1_beta , interleukin-6 and interleukin-8 in the lower uterine segment increased significantly at final cervical dilatation during term parturition , while those of tumor_necrosis_factor_alpha remained unchanged .
8574830	0	interleukin-1_beta	129,147	tumor_necrosis_factor_alpha	100,127	interleukin-1 beta	tumor necrosis factor alpha	3553	7124	Gene	Gene	IL-1_beta|amod|START_ENTITY END_ENTITY|appos|IL-1_beta	Effect of xanthine derivates and dexamethasone on Streptococcus_pneumoniae-stimulated production of tumor_necrosis_factor_alpha , interleukin-1_beta -LRB- IL-1_beta -RRB- , and IL-10 by human leukocytes .
8653494	0	interleukin-1_beta	23,41	tumor_necrosis_factor_alpha	97,124	interleukin-1 beta	tumor necrosis factor alpha	3553	7124	Gene	Gene	production|amod|START_ENTITY phenytoin|nmod|production Effect|nmod|phenytoin challenged|nsubj|Effect challenged|nmod|END_ENTITY	Effect of phenytoin on interleukin-1_beta production in human gingival fibroblasts challenged to tumor_necrosis_factor_alpha in vitro .
9584910	0	interleukin-1_beta	23,41	tumor_necrosis_factor_alpha	99,126	interleukin-1 beta	tumor necrosis factor alpha	3553	7124	Gene	Gene	production|amod|START_ENTITY triclosan|nmod|production Effect|nmod|triclosan challenged|nsubj|Effect challenged|nmod|END_ENTITY	Effect of triclosan on interleukin-1_beta production in human gingival fibroblasts challenged with tumor_necrosis_factor_alpha .
9427519	0	interleukin-1_beta-converting_enzyme	13,49	ICE	51,54	interleukin-1 beta-converting enzyme	ICE	12362(Tax:10090)	12362(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of interleukin-1_beta-converting_enzyme -LRB- ICE -RRB- in murine microglia by lipopolysaccharide .
8034321	0	interleukin-1_beta_converting_enzyme	75,111	ICE	113,116	interleukin-1 beta converting enzyme	ICE	12362(Tax:10090)	12362(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The structure and complete nucleotide sequence of the murine gene encoding interleukin-1_beta_converting_enzyme -LRB- ICE -RRB- .
9987822	0	interleukin-1_beta_converting_enzyme	14,50	ICE	52,55	interleukin-1 beta converting enzyme	ICE	12362(Tax:10090)	12362(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Peptide based interleukin-1_beta_converting_enzyme -LRB- ICE -RRB- inhibitors : synthesis , structure activity relationships and crystallographic study of the ICE-inhibitor complex .
12622883	0	interleukin-1_beta_converting_enzyme	81,117	TNF-alpha	10,19	interleukin-1 beta converting enzyme	TNF-alpha	12362(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Effect|dep|role Effect|nmod|END_ENTITY	Effect of TNF-alpha on the induction of apoptosis in murine macrophages : role of interleukin-1_beta_converting_enzyme .
2148319	0	interleukin-1_receptor	16,38	IL-1R	40,45	interleukin-1 receptor	IL-1R	3554	3554	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of an interleukin-1_receptor -LRB- IL-1R -RRB- on monocytic cells .
26324711	0	interleukin-1_receptor-2	93,117	caspase-1	71,80	interleukin-1 receptor-2	caspase-1	7850	834	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
26324711	0	interleukin-1_receptor-2	93,117	caspase-1	71,80	interleukin-1 receptor-2	caspase-1	7850	834	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
26324711	0	interleukin-1_receptor-2	93,117	caspase-1	71,80	interleukin-1 receptor-2	caspase-1	7850	834	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
26324711	0	interleukin-1_receptor-2	93,117	caspase-1	71,80	interleukin-1 receptor-2	caspase-1	7850	834	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Interleukin-1a activity in necrotic endothelial cells is controlled by caspase-1 cleavage of interleukin-1_receptor-2 ; implications for allograft rejection .
24857403	0	interleukin-1_receptor-associated_kinase_1	31,73	vasodilator-stimulated_phosphoprotein	96,133	interleukin-1 receptor-associated kinase 1	vasodilator-stimulated phosphoprotein	3654	7408	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Isomerase-catalyzed binding of interleukin-1_receptor-associated_kinase_1 to the EVH1 domain of vasodilator-stimulated_phosphoprotein .
24476318	0	interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB	86,150	Serum_amyloid_A	0,15	interleukin-1 receptor-associated kinase 4 and nuclear factor-kB	Serum amyloid A	51135	6287	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Serum_amyloid_A induces interleukin-6 in dermal fibroblasts via Toll-like_receptor_2 , interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB .
9870274	0	interleukin-1_receptor_antagonist	12,45	IL-1RA	47,53	interleukin-1 receptor antagonist	IL-1RA	3557	3557	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating interleukin-1_receptor_antagonist -LRB- IL-1RA -RRB- serum levels in patients undergoing orthotopic heart transplantation .
11380940	0	interleukin-1_receptor_antagonist	57,90	IL-1Ra	92,98	interleukin-1 receptor antagonist	IL-1Ra	3557	3557	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in intron 2 of the human interleukin-1_receptor_antagonist -LRB- IL-1Ra -RRB- gene : further definition of the IL-1_beta and IL-1Ra polymorphisms in North American Caucasians and Taiwanese Chinese .
15205567	0	interleukin-1_receptor_antagonist	46,79	IL-1_RA	81,88	interleukin-1 receptor antagonist	IL-1 RA	3557	3557	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Body mass index but not a polymorphism of the interleukin-1_receptor_antagonist -LRB- IL-1_RA -RRB- gene is associated with age at natural menopause .
22827713	0	interleukin-1_receptor_antagonist	53,86	IL-1ra	88,94	interleukin-1 receptor antagonist	IL-1ra	60582(Tax:10116)	60582(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An experimental study on in situ transfection of the interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- gene into the rat cornea .
23723965	0	interleukin-1_receptor_antagonist	63,96	IL-1ra	98,104	interleukin-1 receptor antagonist	IL-1ra	60582(Tax:10116)	60582(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The experimental treatment of corneal graft rejection with the interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- gene .
8432529	0	interleukin-1_receptor_antagonist	10,43	IL1RN	45,50	interleukin-1 receptor antagonist	IL1RN	3557	3557	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human interleukin-1_receptor_antagonist -LRB- IL1RN -RRB- gene is located in the chromosome 2q14 region .
15627638	0	interleukin-1_receptor_antagonist	68,101	hepatocyte_growth_factor	29,53	interleukin-1 receptor antagonist	hepatocyte growth factor	3557	3082	Gene	Gene	induction|nmod|START_ENTITY effects|dep|induction effects|nmod|END_ENTITY	Anti-inflammatory effects of hepatocyte_growth_factor : induction of interleukin-1_receptor_antagonist .
14766082	0	interleukin-1_receptor_antagonist	26,59	intercellular_adhesion_molecule-1	91,124	interleukin-1 receptor antagonist	intercellular adhesion molecule-1	3557	3383	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- The inhibition effect of interleukin-1_receptor_antagonist on interleukin-1_alpha-induced intercellular_adhesion_molecule-1 expression on orbital fibroblasts and adhesion of peripheral blood mononuclear cells -RSB- .
20429783	0	interleukin-1_receptor_associated_kinase_4	61,103	IRAK-4	105,111	interleukin-1 receptor associated kinase 4	IRAK-4	51135	51135	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Quantitative structure-activity relationship -LRB- QSAR -RRB- study of interleukin-1_receptor_associated_kinase_4 -LRB- IRAK-4 -RRB- inhibitor activity by the genetic algorithm and multiple linear regression -LRB- GA-MLR -RRB- method .
23483993	0	interleukin-1_receptor_like_1	35,64	ST2	66,69	interleukin-1 receptor like 1	ST2	17082(Tax:10090)	17082(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Limited anti-inflammatory role for interleukin-1_receptor_like_1 -LRB- ST2 -RRB- in the host response to murine postinfluenza pneumococcal_pneumonia .
11197691	0	interleukin-1_receptor_type_1	65,94	IL1R1	96,101	interleukin-1 receptor type 1	IL1R1	3554	3554	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of new polymorphisms in the 5 ' UTR of the human interleukin-1_receptor_type_1 -LRB- IL1R1 -RRB- gene : linkage to type 1 diabetes and correlation to IL-1RI plasma level .
11196665	0	interleukin-1_receptor_type_I	94,123	IL-1RI	125,131	interleukin-1 receptor type I	IL-1RI	3554	3554	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of novel single nucleotide polymorphisms in intron 1B and exon 1C of the human interleukin-1_receptor_type_I -LRB- IL-1RI -RRB- gene .
11196719	0	interleukin-1_receptor_type_I	46,75	IL-1RI	77,83	interleukin-1 receptor type I	IL-1RI	3554	3554	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A Bsr BI polymorphism in exon 1C of the human interleukin-1_receptor_type_I -LRB- IL-1RI -RRB- gene .
9168406	0	interleukin-1_receptor_type_II	67,97	Interleukin-1_beta	0,18	interleukin-1 receptor type II	Interleukin-1 beta	7850	3553	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|appos|secretion	Interleukin-1_beta , interleukin-1_receptor_antagonist , and soluble interleukin-1_receptor_type_II secretion in chronic_fatigue_syndrome .
23846687	0	interleukin-1a	120,134	JNK	83,86	interleukin-1a	JNK	3552	5599	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|compound|END_ENTITY	N-myc_downstream-regulated_gene_1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1a by human gastric_cancer cells .
21235388	0	interleukin-1a	23,37	interleukin-1b	39,53	interleukin-1a	interleukin-1b	3552	3553	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Distinct expression of interleukin-1a , interleukin-1b , and interleukin-1 receptor antagonist in testicular tissues and cells from human biopsies with normal and abnormal histology .
21786164	0	interleukin-1a	81,95	interleukin-1b	97,111	interleukin-1a	interleukin-1b	3552	3553	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Duration of wound fluid secretion from chronic venous_leg_ulcers is critical for interleukin-1a , interleukin-1b , interleukin-8 levels and fibroblast activation .
25748836	0	interleukin-1a	13,27	interleukin-1b	73,87	interleukin-1a	interleukin-1b	16175(Tax:10090)	16176(Tax:10090)	Gene	Gene	Knockdown|nmod|START_ENTITY attenuate|nsubj|Knockdown attenuate|dobj|production production|nmod|macrophages macrophages|amod|END_ENTITY	Knockdown of interleukin-1a does not attenuate LPS-induced production of interleukin-1b in mouse macrophages .
21786164	0	interleukin-1a	81,95	interleukin-8	113,126	interleukin-1a	interleukin-8	3552	3576	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Duration of wound fluid secretion from chronic venous_leg_ulcers is critical for interleukin-1a , interleukin-1b , interleukin-8 levels and fibroblast activation .
12505065	0	interleukin-1alpha	88,106	Plasminogen_activator_inhibitor_1	0,33	interleukin-1alpha	Plasminogen activator inhibitor 1	3552	5054	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Plasminogen_activator_inhibitor_1 expression is regulated by the inflammatory mediators interleukin-1alpha , tumor_necrosis_factor-alpha , transforming_growth_factor-beta and oncostatin_M in human cardiac myocytes .
18403889	0	interleukin-1alpha	11,29	basic_fibroblast_growth_factor	63,93	interleukin-1alpha	basic fibroblast growth factor	3552	2247	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effects of interleukin-1alpha on the production and release of basic_fibroblast_growth_factor in cultured nifedipine-reactive gingival fibroblasts .
16203256	0	interleukin-1alpha	42,60	beta-endorphin	62,76	interleukin-1alpha	beta-endorphin	3552	5443	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effect of maternal smoking on breast milk interleukin-1alpha , beta-endorphin , and leptin concentrations and leptin concentrations .
19702713	0	interleukin-1alpha	49,67	interleukin-1	88,101	interleukin-1alpha	interleukin-1	3552	3552	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Graves ' _ ophthalmopathy and gene polymorphisms in interleukin-1alpha , interleukin-1beta , interleukin-1 receptor and interleukin-1 receptor antagonist .
12799211	0	interleukin-1alpha	19,37	interleukin-1beta	39,56	interleukin-1alpha	interleukin-1beta	16175(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY antagonist|nmod|expression antagonist|nsubj|receptor receptor|amod|END_ENTITY	Over expression of interleukin-1alpha , interleukin-1beta and interleukin-1 receptor antagonist in testicular tissues from sexually immature mice as compared to adult mice .
19702713	0	interleukin-1alpha	49,67	interleukin-1beta	69,86	interleukin-1alpha	interleukin-1beta	3552	3553	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Graves ' _ ophthalmopathy and gene polymorphisms in interleukin-1alpha , interleukin-1beta , interleukin-1 receptor and interleukin-1 receptor antagonist .
9767234	0	interleukin-1alpha	143,161	interleukin-1beta	163,180	interleukin-1alpha	interleukin-1beta	3552	3553	Gene	Gene	endothelin-1_and_tumour_necrosis_factor-alpha|amod|START_ENTITY endothelin-1_and_tumour_necrosis_factor-alpha|amod|END_ENTITY	Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes : evidence for a regulatory role of ultraviolet B , interleukin-1alpha , interleukin-1beta , endothelin-1_and_tumour_necrosis_factor-alpha .
22675954	0	interleukin-1alpha	14,32	interleukin-8	73,86	interleukin-1alpha	interleukin-8	3552	3576	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Regulation of interleukin-1alpha and tumor_necrosis_factor-alpha-induced interleukin-8 production by amnion-derived -LRB- WISH -RRB- cells .
11487149	0	interleukin-1alpha	126,144	matrix_metalloproteinase-1_and_tissue_inhibitor_of_metalloproteinase-1	36,106	interleukin-1alpha	matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1	3552	4312	Gene	Gene	fibroblast|nmod|START_ENTITY fibroblast|dobj|expression expression|amod|END_ENTITY	Induction of dental pulp fibroblast matrix_metalloproteinase-1_and_tissue_inhibitor_of_metalloproteinase-1 gene expression by interleukin-1alpha and tumor_necrosis_factor-alpha through a prostaglandin-dependent pathway .
21369818	0	interleukin-1b	74,88	AMP-activated_protein_kinase	104,132	interleukin-1b	AMP-activated protein kinase	3553	5564	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Fenofibric_acid prevents retinal_pigment_epithelium disruption induced by interleukin-1b by suppressing AMP-activated_protein_kinase -LRB- AMPK -RRB- activation .
21369818	0	interleukin-1b	74,88	AMPK	134,138	interleukin-1b	AMPK	3553	5564	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Fenofibric_acid prevents retinal_pigment_epithelium disruption induced by interleukin-1b by suppressing AMP-activated_protein_kinase -LRB- AMPK -RRB- activation .
20883667	0	interleukin-1b	61,75	COX-2	79,84	interleukin-1b	COX-2	3553	4513	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Analysis of isoform specific ERK signaling on the effects of interleukin-1b on COX-2 expression and PGE2 production in human chondrocytes .
20188355	0	interleukin-1b	102,116	Cyclooxygenase-2	0,16	interleukin-1b	Cyclooxygenase-2	3553	5743	Gene	Gene	synthesis|nmod|START_ENTITY induction|nmod|synthesis evidence|nmod|induction END_ENTITY|dep|evidence	Cyclooxygenase-2 in testes of infertile men : evidence for the induction of prostaglandin synthesis by interleukin-1b .
20883667	0	interleukin-1b	61,75	ERK	29,32	interleukin-1b	ERK	3553	5594	Gene	Gene	production|amod|START_ENTITY effects|nmod|production signaling|nmod|effects END_ENTITY|xcomp|signaling	Analysis of isoform specific ERK signaling on the effects of interleukin-1b on COX-2 expression and PGE2 production in human chondrocytes .
25917318	0	interleukin-1b	139,153	Enhancer_of_zeste_homolog-2	0,27	interleukin-1b	Enhancer of zeste homolog-2	3553	2146	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Enhancer_of_zeste_homolog-2 -LRB- EZH2 -RRB- methyltransferase regulates transgelin/smooth muscle-22a expression in endothelial cells in response to interleukin-1b and transforming_growth_factor-b2 .
24647791	0	interleukin-1b	10,24	ICAM-1	28,34	interleukin-1b	ICAM-1	3553	3383	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of interleukin-1b on ICAM-1 expression of dental pulp cells : role of PI3K/Akt , MEK/ERK , and cyclooxygenase .
24839897	0	interleukin-1b	24,38	IL1B	45,49	interleukin-1b	IL1B	3553	3553	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between the interleukin-1b Gene -LRB- IL1B -RRB- C-511T polymorphism and the risk of diabetic_nephropathy in type 2 diabetes : a candidate-gene association study .
21464611	0	interleukin-1b	62,76	NLRP3	103,108	interleukin-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	processing|nmod|START_ENTITY induce|dobj|processing induce|nmod|activation activation|nmod|inflammasome inflammasome|compound|END_ENTITY	Doxorubicin and daunorubicin induce processing and release of interleukin-1b through activation of the NLRP3 inflammasome .
21600797	0	interleukin-1b	66,80	NLRP3	40,45	interleukin-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nummod|END_ENTITY	Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1b activation and severe autoinflammation in mice .
21625424	0	interleukin-1b	43,57	NLRP3	86,91	interleukin-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY trigger|dobj|secretion trigger|advcl|activating activating|dobj|inflammasome inflammasome|compound|END_ENTITY	Polyene_macrolide antifungal drugs trigger interleukin-1b secretion by activating the NLRP3 inflammasome .
21994456	0	interleukin-1b	61,75	NLRP3	33,38	interleukin-1b	NLRP3	3553	114548	Gene	Gene	secretion|amod|START_ENTITY secretion|nummod|END_ENTITY	Measles_virus V protein inhibits NLRP3 inflammasome-mediated interleukin-1b secretion .
22529966	0	interleukin-1b	86,100	NLRP3	26,31	interleukin-1b	NLRP3	3553	114548	Gene	Gene	production|amod|START_ENTITY leading|nmod|production alteration|acl|leading alteration|nsubj|polymorphism polymorphism|nmod|END_ENTITY	The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1b and IL-18 production .
22796220	0	interleukin-1b	54,68	NLRP3	122,127	interleukin-1b	NLRP3	3553	114548	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Oxidized low-density lipoprotein induces secretion of interleukin-1b by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation .
24692555	0	interleukin-1b	52,66	NLRP3	89,94	interleukin-1b	NLRP3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	IL-1b|amod|START_ENTITY IL-1b|acl|activating activating|dobj|inflammasomes inflammasomes|nummod|END_ENTITY	RNA and b-hemolysin of group B Streptococcus induce interleukin-1b -LRB- IL-1b -RRB- by activating NLRP3 inflammasomes in mouse macrophages .
25847326	0	interleukin-1b	58,72	NLRP3	0,5	interleukin-1b	NLRP3	3553	114548	Gene	Gene	inducing|xcomp|START_ENTITY responsible|xcomp|inducing responsible|nsubj|inflammasome inflammasome|compound|END_ENTITY	NLRP3 inflammasome is responsible for Hantavirus inducing interleukin-1b in THP-1 cells .
26074413	0	interleukin-1b	27,41	NLRP3	65,70	interleukin-1b	NLRP3	3553	114548	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Dysregulated production of interleukin-1b upon activation of the NLRP3 inflammasome in patients with familial_Mediterranean_fever .
22848083	0	interleukin-1b	92,106	Nlrp3	4,9	interleukin-1b	Nlrp3	16176(Tax:10090)	216799(Tax:10090)	Gene	Gene	promotes|advcl|START_ENTITY promotes|nsubj|inflammasome inflammasome|amod|END_ENTITY	The Nlrp3 inflammasome promotes myocardial_dysfunction in structural cardiomyopathy through interleukin-1b .
22102411	0	interleukin-1b	7,21	activator_protein_1	99,118	interleukin-1b	activator protein 1	3553	3726	Gene	Gene	IL-1b|amod|START_ENTITY IL-1b|dep|element element|nmod|factors factors|amod|END_ENTITY	Distal interleukin-1b -LRB- IL-1b -RRB- response element of human matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- binds activator_protein_1 -LRB- AP-1 -RRB- transcription factors and regulates gene expression .
21856425	0	interleukin-1b	35,49	cyclooxygenase-2	94,110	interleukin-1b	cyclooxygenase-2	16176(Tax:10090)	19225(Tax:10090)	Gene	Gene	endogenous|amod|START_ENTITY role|nmod|endogenous role|dep|contribution contribution|nmod|END_ENTITY	Neuromodulatory role of endogenous interleukin-1b in acute seizures : possible contribution of cyclooxygenase-2 .
22617488	0	interleukin-1b	120,134	cyclooxygenase-2	65,81	interleukin-1b	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY astrocytes|nmod|interaction END_ENTITY|nmod|astrocytes	Oligomers of b-amyloid protein -LRB- Ab1-42 -RRB- induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1b , tumour_necrosis_factor-a , and a nuclear factor k-B mechanism in the rat brain .
25976054	0	interleukin-1b	26,40	cyclooxygenase-2	48,64	interleukin-1b	cyclooxygenase-2	3553	5743	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Regulatory mechanisms of interleukin-1b on the cyclooxygenase-2 system expression of human neuroglioma cells -RSB- .
22249478	0	interleukin-1b	65,79	hypoxia-inducible_factor-1a	14,41	interleukin-1b	hypoxia-inducible factor-1a	3553	3091	Gene	Gene	IL-1_b|amod|START_ENTITY expression|nmod|IL-1_b expression|amod|END_ENTITY	Regulation of hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- expression by interleukin-1b -LRB- IL-1_b -RRB- , insulin-like_growth_factors_I -LRB- IGF-I -RRB- _ and_II -LRB- IGF-II -RRB- in human osteoarthritic chondrocytes .
21235388	0	interleukin-1b	39,53	interleukin-1a	23,37	interleukin-1b	interleukin-1a	3553	3552	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Distinct expression of interleukin-1a , interleukin-1b , and interleukin-1 receptor antagonist in testicular tissues and cells from human biopsies with normal and abnormal histology .
21786164	0	interleukin-1b	97,111	interleukin-1a	81,95	interleukin-1b	interleukin-1a	3553	3552	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Duration of wound fluid secretion from chronic venous_leg_ulcers is critical for interleukin-1a , interleukin-1b , interleukin-8 levels and fibroblast activation .
25748836	0	interleukin-1b	73,87	interleukin-1a	13,27	interleukin-1b	interleukin-1a	16176(Tax:10090)	16175(Tax:10090)	Gene	Gene	macrophages|amod|START_ENTITY production|nmod|macrophages attenuate|dobj|production attenuate|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of interleukin-1a does not attenuate LPS-induced production of interleukin-1b in mouse macrophages .
24126972	0	interleukin-1b	100,114	interleukin-6	116,129	interleukin-1b	interleukin-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effects of Modified Sanhuang Decoction -LRB- -RRB- enema on serum tumor necrosis factor-a and colonic mucosa interleukin-1b , interleukin-6 levels in ulcerative_colitis rats .
21786164	0	interleukin-1b	97,111	interleukin-8	113,126	interleukin-1b	interleukin-8	3553	3576	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Duration of wound fluid secretion from chronic venous_leg_ulcers is critical for interleukin-1a , interleukin-1b , interleukin-8 levels and fibroblast activation .
23331383	0	interleukin-1b	11,25	macrophage_inflammatory_protein-3a	57,91	interleukin-1b	macrophage inflammatory protein-3a	3553	6364	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|amod|END_ENTITY	Effects of interleukin-1b and tumor_necrosis_factor-a on macrophage_inflammatory_protein-3a production in synovial fibroblast-like cells from human temporomandibular_joints .
22102411	0	interleukin-1b	7,21	matrix_metalloproteinase-13	56,83	interleukin-1b	matrix metalloproteinase-13	3553	4322	Gene	Gene	IL-1b|amod|START_ENTITY IL-1b|dep|element element|nmod|factors factors|amod|END_ENTITY	Distal interleukin-1b -LRB- IL-1b -RRB- response element of human matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- binds activator_protein_1 -LRB- AP-1 -RRB- transcription factors and regulates gene expression .
22920551	0	interleukin-1b	108,122	matrix_metalloproteinase-13	69,96	interleukin-1b	matrix metalloproteinase-13	3553	4322	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Low-intensity pulsed ultrasound inhibits messenger RNA expression of matrix_metalloproteinase-13 induced by interleukin-1b in chondrocytes in an intensity-dependent manner .
22595111	0	interleukin-1b	72,86	vascular_cell_adhesion_molecule-1	14,47	interleukin-1b	vascular cell adhesion molecule-1	3553	7412	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Regulation of vascular_cell_adhesion_molecule-1 in dental pulp cells by interleukin-1b : the role of prostanoids .
14551150	0	interleukin-1beta	17,34	6-pyruvoyltetrahydropterin_synthase	81,116	interleukin-1beta	6-pyruvoyltetrahydropterin synthase	3553	5805	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of interleukin-1beta for transcriptional regulation of endothelial 6-pyruvoyltetrahydropterin_synthase .
9094448	0	interleukin-1beta	54,71	ACTH	37,41	interleukin-1beta	ACTH	24494(Tax:10116)	5443	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Effects of gender and gonadectomy on ACTH response to interleukin-1beta in the rat : comparison with the modulation of ACTH response to immobilization stress .
18050214	0	interleukin-1beta	39,56	ADAMTS-4	70,78	interleukin-1beta	ADAMTS-4	3553	9507	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Involvement of protein_kinase_Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric_oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes .
15880812	0	interleukin-1beta	39,56	ADAMTS-9	0,8	interleukin-1beta	ADAMTS-9	3553	56999	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	ADAMTS-9 is synergistically induced by interleukin-1beta and tumor_necrosis_factor_alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes .
17295899	0	interleukin-1beta	72,89	ATPase	52,58	interleukin-1beta	ATPase	3553	1769	Gene	Gene	production|amod|START_ENTITY regulate|dobj|production regulate|nsubj|domain domain|nmod|isoform isoform|nmod|END_ENTITY	The N-terminus domain of the a2 isoform of vacuolar ATPase can regulate interleukin-1beta production from mononuclear cells in co-culture with JEG-3 choriocarcinoma cells .
17509446	0	interleukin-1beta	77,94	ATPase	67,73	interleukin-1beta	ATPase	3553	1769	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Novel role for the N-terminus domain of the a2 isoform of vacuolar ATPase in interleukin-1beta production .
11290601	0	interleukin-1beta	46,63	Apolipoprotein_A-I	0,18	interleukin-1beta	Apolipoprotein A-I	281251(Tax:9913)	281632(Tax:9913)	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Apolipoprotein_A-I inhibits the production of interleukin-1beta and tumor_necrosis_factor-alpha by blocking contact-mediated activation of monocytes by T lymphocytes .
10812056	0	interleukin-1beta	100,117	Bradykinin	0,10	interleukin-1beta	Bradykinin	3553	3827	Gene	Gene	mobilization|amod|START_ENTITY pretreated|nmod|mobilization release|acl|pretreated prostaglandin_E|dobj|release prostaglandin_E|nsubj|potentiates potentiates|compound|END_ENTITY	Bradykinin potentiates prostaglandin_E -LRB- 2 -RRB- release in the human gingival fibroblasts pretreated with interleukin-1beta via Ca -LRB- 2 + -RRB- mobilization .
11408528	0	interleukin-1beta	40,57	Bradykinin_B1_receptor	0,22	interleukin-1beta	Bradykinin B1 receptor	3553	623	Gene	Gene	agonist|amod|START_ENTITY up-regulation|nmod|agonist up-regulation|amod|END_ENTITY	Bradykinin_B1_receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts .
11114294	0	interleukin-1beta	77,94	CFTR	37,41	interleukin-1beta	CFTR	3553	1080	Gene	Gene	mediates|advcl|START_ENTITY mediates|dobj|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	NF-kappa_B mediates up-regulation of CFTR gene expression in Calu-3 cells by interleukin-1beta .
11278608	0	interleukin-1beta	112,129	CFTR	103,107	interleukin-1beta	CFTR	3553	1080	Gene	Gene	involved|advcl|START_ENTITY involved|nmod|regulation regulation|nmod|cystic_fibrosis_transmembrane_conductance_regulator cystic_fibrosis_transmembrane_conductance_regulator|appos|END_ENTITY	NF-kappaB activation is involved in regulation of cystic_fibrosis_transmembrane_conductance_regulator -LRB- CFTR -RRB- by interleukin-1beta .
11489266	0	interleukin-1beta	58,75	Cyclooxygenase-2	0,16	interleukin-1beta	Cyclooxygenase-2	16176(Tax:10090)	19225(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta .
12050157	0	interleukin-1beta	61,78	Cyclooxygenase-2	0,16	interleukin-1beta	Cyclooxygenase-2	3553	5743	Gene	Gene	peptide|amod|START_ENTITY induced|nmod|peptide expression|acl|induced expression|compound|END_ENTITY	Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells .
10225546	0	interleukin-1beta	24,41	Cyclosporin_A	0,13	interleukin-1beta	Cyclosporin A	3553	1161	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Cyclosporin_A regulates interleukin-1beta and interleukin-6 expression in gingiva : implications for gingival_overgrowth .
12637574	0	interleukin-1beta	73,90	Egr-1	0,5	interleukin-1beta	Egr-1	3553	1958	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Egr-1 mediates transcriptional repression of COL2A1 promoter activity by interleukin-1beta .
19843519	0	interleukin-1beta	98,115	Histone_deacetylase-1	0,21	interleukin-1beta	Histone deacetylase-1	3553	3065	Gene	Gene	enriched|nmod|START_ENTITY enriched|nsubjpass|END_ENTITY	Histone_deacetylase-1 is enriched at the platelet-derived_growth_factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab_p65 and interferon_regulatory_factor-1 .
12588662	0	interleukin-1beta	33,50	IL-1beta	52,60	interleukin-1beta	IL-1beta	16176(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of flavone derivatives on interleukin-1beta -LRB- IL-1beta -RRB- mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages .
12706488	0	interleukin-1beta	26,43	IL-1beta	50,58	interleukin-1beta	IL-1beta	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study between interleukin-1beta gene -LRB- IL-1beta -RRB- and schizophrenia .
18541658	0	interleukin-1beta	3,20	IL-1beta	22,30	interleukin-1beta	IL-1beta	3553	3553	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	An interleukin-1beta -LRB- IL-1beta -RRB- single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of IL-1beta in diseased periodontal tissues .
9482809	0	interleukin-1beta	33,50	IL-1beta	52,60	interleukin-1beta	IL-1beta	24494(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Vagotomy_blocks the induction of interleukin-1beta -LRB- IL-1beta -RRB- mRNA in the brain of rats in response to systemic_IL-1beta .
12524080	0	interleukin-1beta	62,79	Interleukin-8	0,13	interleukin-1beta	Interleukin-8	3553	3576	Gene	Gene	up-regulated|advcl|START_ENTITY up-regulated|nsubj|gene gene|amod|END_ENTITY	Interleukin-8 gene and protein expression are up-regulated by interleukin-1beta in normal human ovarian cells and a granulosa tumor cell line .
20373993	0	interleukin-1beta	15,32	Interleukin-8	0,13	interleukin-1beta	Interleukin-8	396565(Tax:9823)	100620730	Gene	Gene	linked|nsubjpass|START_ENTITY linked|advmod|END_ENTITY	Interleukin-8 , interleukin-1beta , and interferon-gamma levels are linked to PRRS virus clearance .
12213309	0	interleukin-1beta	17,34	Leptin	0,6	interleukin-1beta	Leptin	16176(Tax:10090)	16846(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms .
17074047	0	interleukin-1beta	56,73	Leptin	0,6	interleukin-1beta	Leptin	24494(Tax:10116)	25608(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY cyclooxygenase-2|nmod|interaction induces|xcomp|cyclooxygenase-2 induces|nsubj|END_ENTITY	Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain .
17419800	0	interleukin-1beta	15,32	Leptin	0,6	interleukin-1beta	Leptin	24494(Tax:10116)	25608(Tax:10116)	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Leptin induces interleukin-1beta release from rat microglial cells through a caspase_1 independent mechanism .
18535786	0	interleukin-1beta	50,67	Leptin	0,6	interleukin-1beta	Leptin	24494(Tax:10116)	25608(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY modulates|dobj|effect modulates|nsubj|END_ENTITY	Leptin modulates the negative inotropic effect of interleukin-1beta in cardiac myocytes .
19009554	0	interleukin-1beta	26,43	Lipocalin-2	0,11	interleukin-1beta	Lipocalin-2	16176(Tax:10090)	16819(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Lipocalin-2 is induced by interleukin-1beta in murine adipocytes in vitro .
16939904	0	interleukin-1beta	9,26	MMP-9	73,78	interleukin-1beta	MMP-9	3553	4318	Gene	Gene	START_ENTITY|advcl|regulating regulating|dobj|END_ENTITY	-LSB- Role of interleukin-1beta in regulating human cultured endometrial cell MMP-9 and TIMP-3 expressions in the mid-secretory phase -RSB- .
10594073	0	interleukin-1beta	21,38	NF-kappaB	52,61	interleukin-1beta	NF-kappaB	16176(Tax:10090)	18033(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia .
11114294	0	interleukin-1beta	77,94	NF-kappa_B	0,10	interleukin-1beta	NF-kappa B	3553	4790	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	NF-kappa_B mediates up-regulation of CFTR gene expression in Calu-3 cells by interleukin-1beta .
11976320	0	interleukin-1beta	14,31	NF-kappa_B	41,51	interleukin-1beta	NF-kappa B	3553	4790	Gene	Gene	START_ENTITY|acl|induced induced|dobj|activation activation|amod|END_ENTITY	Inhibition of interleukin-1beta - induced NF-kappa_B activation by calcium/calmodulin-dependent _ protein_kinase_kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88 .
16455661	0	interleukin-1beta	11,28	NFkappaB	70,78	interleukin-1beta	NFkappaB	3553	4790	Gene	Gene	signaling|amod|START_ENTITY causes|nsubj|signaling causes|dobj|activation activation|nmod|END_ENTITY	Persistent interleukin-1beta signaling causes long term activation of NFkappaB in a promoter-specific manner in human glial cells .
19801678	0	interleukin-1beta	38,55	NFkappaB	91,99	interleukin-1beta	NFkappaB	3553	4790	Gene	Gene	IL-1beta|amod|START_ENTITY IL-1beta|dep|activation activation|nmod|END_ENTITY	Lipid rafts and caveolin-1 coordinate interleukin-1beta -LRB- IL-1beta -RRB- - dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane .
17207896	0	interleukin-1beta	57,74	Neuropeptide_Y	0,14	interleukin-1beta	Neuropeptide Y	16176(Tax:10090)	109648(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY evoked|nmod|cells release|acl|evoked regulates|dobj|release regulates|nsubj|END_ENTITY	Neuropeptide_Y regulates catecholamine release evoked by interleukin-1beta in mouse chromaffin cells .
15612946	0	interleukin-1beta	45,62	Retinoic_acid-inducible_gene-I	0,30	interleukin-1beta	Retinoic acid-inducible gene-I	3553	23586	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Retinoic_acid-inducible_gene-I is induced by interleukin-1beta in cultured human gingival fibroblasts .
18452164	0	interleukin-1beta	33,50	SAA3	14,18	interleukin-1beta	SAA3	16176(Tax:10090)	20210(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes .
17032168	0	interleukin-1beta	65,82	Stat1	11,16	interleukin-1beta	Stat1	16176(Tax:10090)	20846(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expression .
17929249	0	interleukin-1beta	39,56	VEGF-D	18,24	interleukin-1beta	VEGF-D	24494(Tax:10116)	360457(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Downregulation of VEGF-D expression by interleukin-1beta in cardiac microvascular endothelial cells is mediated by MAPKs and PKCalpha/beta1 .
10223286	0	interleukin-1beta	91,108	alpha-MSH	11,20	interleukin-1beta	alpha-MSH	24494(Tax:10116)	24664(Tax:10116)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Endogenous alpha-MSH modulates the hypothalamic-pituitary-adrenal response to the cytokine interleukin-1beta .
11435921	0	interleukin-1beta	83,100	alpha-synuclein	14,29	interleukin-1beta	alpha-synuclein	3553	6622	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1beta .
19668572	0	interleukin-1beta	24,41	amyloid_precursor_protein	55,80	interleukin-1beta	amyloid precursor protein	24494(Tax:10116)	54226(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of interleukin-1beta and S100B on amyloid_precursor_protein in rat retinal neurons .
10419551	0	interleukin-1beta	68,85	bradykinin	18,28	interleukin-1beta	bradykinin	3553	3827	Gene	Gene	shift|amod|START_ENTITY presence|nmod|shift agonists|nmod|presence Autoregulation|dep|agonists Autoregulation|nmod|receptors receptors|compound|END_ENTITY	Autoregulation of bradykinin receptors : agonists in the presence of interleukin-1beta shift the repertoire of receptor subtypes from B2 to B1 in human lung fibroblasts .
9726641	0	interleukin-1beta	71,88	bradykinin	28,38	interleukin-1beta	bradykinin	3553	3827	Gene	Gene	cells|amod|START_ENTITY induced|nmod|cells increase|acl|induced increase|amod|END_ENTITY	Glucocorticoids inhibit the bradykinin B2 receptor increase induced by interleukin-1beta in human bronchial smooth muscle cells .
10362533	0	interleukin-1beta	14,31	bradykinin_B1_receptor	54,76	interleukin-1beta	bradykinin B1 receptor	16176(Tax:10090)	12061(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Regulation by interleukin-1beta of gene expression of bradykinin_B1_receptor in MH-S murine alveolar macrophage cell line .
9461531	0	interleukin-1beta	10,27	bradykinin_B1_receptor	98,120	interleukin-1beta	bradykinin B1 receptor	3553	623	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|control control|nmod|expression expression|amod|END_ENTITY	Roles for interleukin-1beta , phorbol_ester and a post-transcriptional regulator in the control of bradykinin_B1_receptor gene expression .
17192486	0	interleukin-1beta	24,41	caspase-1	14,23	interleukin-1beta	caspase-1	16176(Tax:10090)	12362(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Inhibition of caspase-1 / interleukin-1beta signaling prevents degeneration_of_retinal_capillaries in diabetes and galactosemia .
11453113	0	interleukin-1beta	75,92	collagenase-2	13,26	interleukin-1beta	collagenase-2	3553	4317	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of collagenase-2 -LRB- matrix_metalloproteinase-8 -RRB- gene expression by interleukin-1beta in human gingival fibroblasts .
10523409	0	interleukin-1beta	84,101	cyclooxygenase-2	13,29	interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta : involvement of p38_mitogen-activated_protein_kinase .
11082190	0	interleukin-1beta	115,132	cyclooxygenase-2	76,92	interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|role role|nmod|factors factors|nmod|stimulation stimulation|nmod|gene gene|amod|END_ENTITY	Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1beta in articular chondrocytes .
12727794	0	interleukin-1beta	55,72	cyclooxygenase-2	14,30	interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	Expression|acl|START_ENTITY Expression|nmod|expression expression|amod|END_ENTITY	Expression of cyclooxygenase-2 parallels expression of interleukin-1beta , interleukin-6 and NF-kappaB in human colorectal_cancer .
15067222	0	interleukin-1beta	82,99	cyclooxygenase-2	13,29	interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression in human tracheal smooth muscle cells by interleukin-1beta : involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-kappaB .
15950779	0	interleukin-1beta	45,62	cyclooxygenase-2	18,34	interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	pathways|amod|START_ENTITY system|nmod|pathways system|amod|END_ENTITY	Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways : a comparative study of human neuroglioma_and_neuroblastoma cells .
17074047	0	interleukin-1beta	56,73	cyclooxygenase-2	15,31	interleukin-1beta	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain .
18262365	0	interleukin-1beta	8,25	cyclooxygenase-2	82,98	interleukin-1beta	cyclooxygenase-2	16176(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|mRNA mRNA|amod|END_ENTITY	Role of interleukin-1beta and tumor_necrosis_factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic_inflammation in mice .
19029777	0	interleukin-1beta	44,61	cyclooxygenase-2	13,29	interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	line|amod|START_ENTITY Induction|nmod|line Induction|nmod|expression expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression by interleukin-1beta in human glioma cell line , U87MG .
20424388	0	interleukin-1beta	67,84	cyclooxygenase-2	35,51	interleukin-1beta	cyclooxygenase-2	24494(Tax:10116)	29527(Tax:10116)	Gene	Gene	expressing|nmod|START_ENTITY expressing|xcomp|END_ENTITY	Identification of cells expressing cyclooxygenase-2 in response to interleukin-1beta in rat aortae .
9275047	0	interleukin-1beta	79,96	cyclooxygenase-2	13,29	interleukin-1beta	cyclooxygenase-2	3553	5743	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of cyclooxygenase-2 and prostaglandin_F2alpha_receptor expression by interleukin-1beta in cultured human granulosa-luteal cells .
10226077	0	interleukin-1beta	34,51	fibrinogen	65,75	interleukin-1beta	fibrinogen	3553	2244	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|engagement engagement|compound|END_ENTITY	Transcriptional regulation of the interleukin-1beta promoter via fibrinogen engagement of the CD18 integrin receptor .
18380966	0	interleukin-1beta	42,59	fibrinogen	11,21	interleukin-1beta	fibrinogen	3553	2244	Gene	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Effect of fibrinogen on the secretion of interleukin-1beta and - 8 by polymorphonuclear leukocytes -RSB- .
11704656	0	interleukin-1beta	36,53	gp120	19,24	interleukin-1beta	gp120	3553	3700	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells : evidence for a role in the mechanism of cell death .
15266826	0	interleukin-1beta	14,31	growth_hormone	43,57	interleukin-1beta	growth hormone	24494(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- Mechanism of interleukin-1beta increasing growth_hormone expression in rat pituitary GH3 cells -RSB- .
16043966	0	interleukin-1beta	22,39	growth_hormone	43,57	interleukin-1beta	growth hormone	24494(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Stimulatory effect of interleukin-1beta on growth_hormone gene expression and growth_hormone release from rat GH3 cells .
11742864	0	interleukin-1beta	50,67	inducible_NO_synthase	83,104	interleukin-1beta	inducible NO synthase	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Persistent activation of nuclear factor-kappaB by interleukin-1beta and subsequent inducible_NO_synthase expression requires extracellular_signal-regulated_kinase .
15350552	0	interleukin-1beta	107,124	inducible_nitric_oxide_synthase	30,61	interleukin-1beta	inducible nitric oxide synthase	24494(Tax:10116)	24599(Tax:10116)	Gene	Gene	stimulated|advcl|START_ENTITY hepatocytes|acl|stimulated END_ENTITY|nmod|hepatocytes	Cycloprodigiosin up-regulates inducible_nitric_oxide_synthase gene expression in hepatocytes stimulated by interleukin-1beta .
21932667	0	interleukin-1beta	34,51	inducible_nitric_oxide_synthase	73,104	interleukin-1beta	inducible nitric oxide synthase	3553	4843	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	-LSB- Effect of lipopolysaccharide and interleukin-1beta on the expression of inducible_nitric_oxide_synthase gene in human periodontal ligament cells -RSB- .
10965886	0	interleukin-1beta	73,90	insulin-like_growth_factor_binding_protein-1	15,59	interleukin-1beta	insulin-like growth factor binding protein-1	3553	3484	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Stimulation of insulin-like_growth_factor_binding_protein-1 synthesis by interleukin-1beta : requirement of the mitogen-activated protein kinase pathway .
11122355	0	interleukin-1beta	8,25	interleukin-1	122,135	interleukin-1beta	interleukin-1	16176(Tax:10090)	111343(Tax:10090)	Gene	Gene	factor-alpha|compound|START_ENTITY Role|nmod|factor-alpha Role|dep|study study|nmod|mice mice|amod|END_ENTITY	Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour : a study with interleukin-1 type I receptor-deficient mice .
15735988	0	interleukin-1beta	34,51	interleukin-1	74,87	interleukin-1beta	interleukin-1	3553	3552	Gene	Gene	receptor|amod|START_ENTITY Concentration|nmod|receptor Concentration|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Concentration of interleukin-18 , interleukin-1beta , soluble receptor for interleukin-1 -LRB- sIL-1RII -RRB- and C-reactive_protein in patients with neuroborreliosis -RSB- .
17763411	0	interleukin-1beta	11,28	interleukin-1	98,111	interleukin-1beta	interleukin-1	3553	3552	Gene	Gene	secretion|amod|START_ENTITY Pattern|nmod|secretion Pattern|acl|lipopolysaccharide lipopolysaccharide|nmod|blockade blockade|amod|END_ENTITY	Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations .
19702713	0	interleukin-1beta	69,86	interleukin-1	88,101	interleukin-1beta	interleukin-1	3553	3552	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Graves ' _ ophthalmopathy and gene polymorphisms in interleukin-1alpha , interleukin-1beta , interleukin-1 receptor and interleukin-1 receptor antagonist .
12571842	0	interleukin-1beta	70,87	interleukin-18	15,29	interleukin-1beta	interleukin-18	3553	3606	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|expression expression|amod|END_ENTITY	Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor_necrosis_factor_alpha in knee synovial tissue of patients with rheumatoid_arthritis .
15735988	0	interleukin-1beta	34,51	interleukin-18	18,32	interleukin-1beta	interleukin-18	3553	3606	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	-LSB- Concentration of interleukin-18 , interleukin-1beta , soluble receptor for interleukin-1 -LRB- sIL-1RII -RRB- and C-reactive_protein in patients with neuroborreliosis -RSB- .
12799211	0	interleukin-1beta	39,56	interleukin-1alpha	19,37	interleukin-1beta	interleukin-1alpha	16176(Tax:10090)	16175(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY antagonist|nsubj|receptor antagonist|nmod|expression expression|nmod|END_ENTITY	Over expression of interleukin-1alpha , interleukin-1beta and interleukin-1 receptor antagonist in testicular tissues from sexually immature mice as compared to adult mice .
19702713	0	interleukin-1beta	69,86	interleukin-1alpha	49,67	interleukin-1beta	interleukin-1alpha	3553	3552	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Graves ' _ ophthalmopathy and gene polymorphisms in interleukin-1alpha , interleukin-1beta , interleukin-1 receptor and interleukin-1 receptor antagonist .
9767234	0	interleukin-1beta	163,180	interleukin-1alpha	143,161	interleukin-1beta	interleukin-1alpha	3553	3552	Gene	Gene	endothelin-1_and_tumour_necrosis_factor-alpha|amod|START_ENTITY endothelin-1_and_tumour_necrosis_factor-alpha|amod|END_ENTITY	Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes : evidence for a regulatory role of ultraviolet B , interleukin-1alpha , interleukin-1beta , endothelin-1_and_tumour_necrosis_factor-alpha .
9575225	0	interleukin-1beta	30,47	interleukin-1beta	56,73	interleukin-1beta	interleukin-1beta	281251(Tax:9913)	281251(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of interleukin-1beta gene by interleukin-1beta itself is mediated in part by Oct-1 in thymic stromal cells .
9575225	0	interleukin-1beta	56,73	interleukin-1beta	30,47	interleukin-1beta	interleukin-1beta	281251(Tax:9913)	281251(Tax:9913)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of interleukin-1beta gene by interleukin-1beta itself is mediated in part by Oct-1 in thymic stromal cells .
10391095	0	interleukin-1beta	44,61	interleukin-6	185,198	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	effects|nmod|START_ENTITY Enhancement|nmod|effects LNCaP|nsubj|Enhancement LNCaP|nmod|END_ENTITY	Enhancement of antiproliferative effects of interleukin-1beta and tumor_necrosis_factor-alpha on human prostate_cancer LNCaP cells by coculture with normal fibroblasts through secreted interleukin-6 .
10590238	0	interleukin-1beta	120,137	interleukin-6	21,34	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	synergy|nmod|START_ENTITY expression|dep|synergy expression|amod|END_ENTITY	Oncostatin_M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta .
11174046	0	interleukin-1beta	25,42	interleukin-6	44,57	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Plasma concentrations of interleukin-1beta , interleukin-6 , soluble interleukin-2 receptor and tumor necrosis factor alpha of depressed patients in Japan .
12165795	0	interleukin-1beta	46,63	interleukin-6	67,80	interleukin-1beta	interleukin-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Additive effects of amyloid beta fragment and interleukin-1beta on interleukin-6 secretion in rat primary glial cultures .
12668157	0	interleukin-1beta	40,57	interleukin-6	15,28	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes .
12873450	0	interleukin-1beta	147,164	interleukin-6	47,60	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	line|amod|START_ENTITY induced|nmod|line induced|nsubj|Effects Effects|nmod|baicalin baicalin|nmod|expression expression|amod|END_ENTITY	Effects of baicalin , baicalein , and wogonin on interleukin-6 and interleukin-8 expression , and nuclear_factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line .
12957790	0	interleukin-1beta	55,72	interleukin-6	27,40	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|expression expression|amod|END_ENTITY	Differential modulation of interleukin-6 expression by interleukin-1beta in neuronal and glial cultures .
15716832	0	interleukin-1beta	56,73	interleukin-6	41,54	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	tumor|amod|START_ENTITY tumor|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , interleukin-6 , interleukin-1beta , soluble tumor necrosis factor receptors I and II , interleukin-6 soluble receptor , interleukin-1 soluble receptor type II , interleukin-1 receptor antagonist , and protein in the synovial fluid of patients with temporomandibular_joint_disorders .
8703029	0	interleukin-1beta	38,55	interleukin-6	59,72	interleukin-1beta	interleukin-6	16176(Tax:10090)	16193(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit_ligand and interleukin-10 in mouse bone marrow-derived mast cells .
9326296	0	interleukin-1beta	177,194	interleukin-6	33,46	interleukin-1beta	interleukin-6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	cytokine|xcomp|START_ENTITY cytokine|nsubj|Regulation Regulation|nmod|genes genes|acl|encoding encoding|dobj|END_ENTITY	Regulation of the genes encoding interleukin-6 , its receptor , and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta .
9772027	0	interleukin-1beta	113,130	interleukin-6	132,145	interleukin-1beta	interleukin-6	3553	3569	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Longitudinal study of inflammatory factors in serum , cerebrospinal fluid , and brain tissue in Alzheimer_disease : interleukin-1beta , interleukin-6 , interleukin-1 receptor antagonist , tumor_necrosis_factor-alpha , the soluble tumor necrosis factor receptors I and II , and alpha1-antichymotrypsin .
10946822	0	interleukin-1beta	9,26	interleukin-6_and_tumor_necrosis_factor-alpha	28,73	interleukin-1beta	interleukin-6 and tumor necrosis factor-alpha	3553	3569;7124	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Enhanced interleukin-1beta , interleukin-6_and_tumor_necrosis_factor-alpha production by LPS stimulated human monocytes isolated from HIV + patients .
12873794	0	interleukin-1beta	109,126	interleukin-6_and_tumor_necrosis_factor-alpha	128,173	interleukin-1beta	interleukin-6 and tumor necrosis factor-alpha	3553	3569;7124	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Effect of calcitonin gene-related peptide , neuropeptide_Y , substance_P , and vasoactive_intestinal_peptide on interleukin-1beta , interleukin-6_and_tumor_necrosis_factor-alpha production by peripheral whole blood cells from rheumatoid_arthritis and osteoarthritis patients .
10641976	0	interleukin-1beta	139,156	interleukin-8	13,26	interleukin-1beta	interleukin-8	3553	3576	Gene	Gene	inhibitors|nmod|START_ENTITY affected|nmod|inhibitors affected|nsubjpass|Induction Induction|nmod|release release|amod|END_ENTITY	Induction of interleukin-8 release by lung epithelium with cystic_fibrosis epithelial lining fluid is marginally affected by inhibitors of interleukin-1beta .
12533683	0	interleukin-1beta	79,96	interleukin-8	156,169	interleukin-1beta	interleukin-8	3553	3576	Gene	Gene	induced|advcl|START_ENTITY GCP-2|dep|induced GCP-2|dep|comparison comparison|nmod|CXCL8 CXCL8|amod|END_ENTITY	The CXC chemokine GCP-2 / CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma : comparison with interleukin-8 / CXCL8 .
16678783	0	interleukin-1beta	120,137	interleukin-8	49,62	interleukin-1beta	interleukin-8	3553	3576	Gene	Gene	stimulated|advcl|START_ENTITY fibroblasts|acl|stimulated enhances|nmod|fibroblasts enhances|dobj|production production|amod|END_ENTITY	Epidermal_growth_factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1beta .
8663179	0	interleukin-1beta	47,64	interleukin-8	14,27	interleukin-1beta	interleukin-8	3553	3576	Gene	Gene	hormones|amod|START_ENTITY expression|nmod|hormones expression|amod|END_ENTITY	Regulation of interleukin-8 gene expression by interleukin-1beta , osteotropic hormones , and protein kinase inhibitors in normal human bone marrow stromal cells .
9797111	0	interleukin-1beta	43,60	interleukin-8	62,75	interleukin-1beta	interleukin-8	100008990(Tax:9986)	100009129(Tax:9986)	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Analysis of the cytokine interaction among interleukin-1beta , interleukin-8 , and interleukin-1 receptor antagonist in the rabbit ovulatory process .
9624172	0	interleukin-1beta	81,98	low_density_lipoprotein_receptor	140,172	interleukin-1beta	low density lipoprotein receptor	3553	3949	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Differential roles of extracellular_signal-regulated_kinase-1 / 2 and p38 -LRB- MAPK -RRB- in interleukin-1beta - and tumor_necrosis_factor-alpha-induced low_density_lipoprotein_receptor expression in HepG2 cells .
19309436	0	interleukin-1beta	98,115	neuropeptide_Y	125,139	interleukin-1beta	neuropeptide Y	3553	4852	Gene	Gene	cells|nmod|START_ENTITY Regulation|nmod|cells Regulation|dep|role role|nmod|END_ENTITY	Regulation of catecholamine release and tyrosine_hydroxylase in human adrenal chromaffin cells by interleukin-1beta : role of neuropeptide_Y and nitric_oxide .
17320050	0	interleukin-1beta	13,30	p65	80,83	interleukin-1beta	p65	24494(Tax:10116)	25716(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|nmod|END_ENTITY	NMDA-induced interleukin-1beta expression is mediated by nuclear factor-kappa B p65 in the retina .
9354589	0	interleukin-1beta	88,105	peroxisome_proliferator-activated_receptor_alpha	25,73	interleukin-1beta	peroxisome proliferator-activated receptor alpha	24494(Tax:10116)	25747(Tax:10116)	Gene	Gene	expression|acl|START_ENTITY expression|amod|END_ENTITY	Regulation of CYP4A1 and peroxisome_proliferator-activated_receptor_alpha expression by interleukin-1beta , interleukin-6 , and dexamethasone in cultured fetal rat hepatocytes .
15087710	0	interleukin-1beta	11,28	prostaglandin_D_synthase	53,77	interleukin-1beta	prostaglandin D synthase	24494(Tax:10116)	25526(Tax:10116)	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of interleukin-1beta and prostaglandin_E2 on prostaglandin_D_synthase production in cultivated rat leptomeningeal cells .
19950280	0	interleukin-1beta	135,152	proteinase_3	73,85	interleukin-1beta	proteinase 3	16176(Tax:10090)	19152(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Inflammatory arthritis in caspase_1 gene-deficient mice : contribution of proteinase_3 to caspase_1-independent production of bioactive interleukin-1beta .
15068113	0	interleukin-1beta	22,39	receptor_activator_of_nuclear_factor-kappaB_ligand	78,128	interleukin-1beta	receptor activator of nuclear factor-kappaB ligand	3553	8600	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of interleukin-1beta and prostaglandin_E2 on expression of receptor_activator_of_nuclear_factor-kappaB_ligand in human periodontal ligament cells .
16207716	0	interleukin-1beta	70,87	thioredoxin-1	20,33	interleukin-1beta	thioredoxin-1	3553	7295	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human_monocyte-derived_macrophages .
25048558	0	interleukin-1beta	70,87	transforming_growth_factor_beta1	117,149	interleukin-1beta	transforming growth factor beta1	3553	7040	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Topical ALA-PDT modifies neutrophils ' chemiluminescence , lymphocytes ' interleukin-1beta secretion and serum level of transforming_growth_factor_beta1 in patients with nonmelanoma skin_malignancies A clinical study .
15716832	0	interleukin-1beta	56,73	tumor_necrosis_factor-alpha	12,39	interleukin-1beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	tumor|amod|START_ENTITY tumor|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , interleukin-6 , interleukin-1beta , soluble tumor necrosis factor receptors I and II , interleukin-6 soluble receptor , interleukin-1 soluble receptor type II , interleukin-1 receptor antagonist , and protein in the synovial fluid of patients with temporomandibular_joint_disorders .
10408390	0	interleukin-1beta	85,102	vascular_endothelial_growth_factor	14,48	interleukin-1beta	vascular endothelial growth factor	3553	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression in human colon_cancer by interleukin-1beta .
12792892	0	interleukin-1beta	107,124	vascular_endothelial_growth_factor	16,50	interleukin-1beta	vascular endothelial growth factor	16176(Tax:10090)	22339(Tax:10090)	Gene	Gene	IL-1beta|amod|START_ENTITY overexpressing|dobj|IL-1beta overexpressing|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the retinas of transgenic_mice overexpressing interleukin-1beta -LRB- IL-1beta -RRB- in the lens and mice undergoing retinal_degeneration .
15349119	0	interleukin-1beta	93,110	vascular_endothelial_growth_factor	14,48	interleukin-1beta	vascular endothelial growth factor	3553	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression in human gastric_cancer cells by interleukin-1beta .
10359086	0	interleukin-1beta-converting_enzyme	54,89	ICE	91,94	interleukin-1beta-converting enzyme	ICE	834	834	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Defective binding of IRFs to the initiator element of interleukin-1beta-converting_enzyme -LRB- ICE -RRB- promoter in an interferon-resistant Daudi subline .
9104815	0	interleukin-1beta-converting_enzyme	43,78	ICE	80,83	interleukin-1beta-converting enzyme	ICE	834	834	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Human vascular smooth muscle cells express interleukin-1beta-converting_enzyme -LRB- ICE -RRB- , but inhibit processing of the interleukin-1beta precursor by ICE .
14598973	0	interleukin-1beta_converting_enzyme	9,44	ICE	46,49	interleukin-1beta converting enzyme	ICE	834	834	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Impaired interleukin-1beta_converting_enzyme -LRB- ICE -RRB- activity in patients with pulmonary_tuberculosis .
16782334	0	interleukin-1beta_converting_enzyme	89,124	ICE	126,129	interleukin-1beta converting enzyme	ICE	834	834	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and evaluation of novel 1 - -LRB- 2-acylhydrazinocarbonyl -RRB- - cycloalkyl_carboxamides as interleukin-1beta_converting_enzyme -LRB- ICE -RRB- inhibitors .
16870441	0	interleukin-1beta_converting_enzyme	43,78	ICE	80,83	interleukin-1beta converting enzyme	ICE	834	834	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and evaluation of thiazepines as interleukin-1beta_converting_enzyme -LRB- ICE -RRB- inhibitors .
17127070	0	interleukin-1beta_converting_enzyme	56,91	ICE	93,96	interleukin-1beta converting enzyme	ICE	834	834	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta_converting_enzyme -LRB- ICE -RRB- inhibitors .
20674352	0	interleukin-1beta_converting_enzyme	14,49	ICE_or_caspase_1	51,67	interleukin-1beta converting enzyme	ICE or caspase 1	834	834	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of interleukin-1beta_converting_enzyme -LRB- ICE_or_caspase_1 -RRB- by aspartyl_acyloxyalkyl_ketones and aspartyl_amidooxyalkyl_ketones .
16880512	0	interleukin-2	23,36	ALX	118,121	interleukin-2	ALX	16183(Tax:10090)	14294(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY kinase|nsubj|regulation kinase|nmod|END_ENTITY	Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX .
24765159	0	interleukin-2	33,46	B7-H4	0,5	interleukin-2	B7-H4	3558	79679	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	B7-H4 expression and its role in interleukin-2 / interferon treatment of clear_cell_renal_cell_carcinoma .
1477186	0	interleukin-2	24,37	Beta-endorphin	0,14	interleukin-2	Beta-endorphin	16183(Tax:10090)	18976(Tax:10090)	Gene	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes .
2833533	0	interleukin-2	24,37	Beta-endorphin	0,14	interleukin-2	Beta-endorphin	16183(Tax:10090)	18976(Tax:10090)	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Beta-endorphin enhances interleukin-2 -LRB- IL-2 -RRB- production in murine lymphocytes .
26155126	0	interleukin-2	78,91	CD11b	14,19	interleukin-2	CD11b	3558	3684	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of CD11b and CD18 on polymorphonuclear neutrophils stimulated with interleukin-2 .
7519476	0	interleukin-2	100,113	CD2	57,60	interleukin-2	CD2	3558	914	Gene	Gene	ligation|nmod|START_ENTITY ligation|compound|END_ENTITY	Maturation of acute_T-lymphoblastic_leukemia cells after CD2 ligation and subsequent treatment with interleukin-2 .
11182148	0	interleukin-2	155,168	CD25	103,107	interleukin-2	CD25	396868(Tax:9823)	396814(Tax:9823)	Gene	Gene	vitro|nmod|START_ENTITY generated|advcl|vitro phenotype|acl|generated phenotype|compound|END_ENTITY	Functional characterization of a swine CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- double positive lymphoblastoid T-cell line with a CD25 -LRB- + -RRB- / CD45RA -LRB- - -RRB- phenotype generated in vitro with interleukin-2 .
1462123	0	interleukin-2	42,55	CD25	144,148	interleukin-2	CD25	3558	3559	Gene	Gene	transcription|nmod|START_ENTITY Spontaneous|nmod|transcription _|nsubj|Spontaneous _|xcomp|interleukin-2_receptor interleukin-2_receptor|dep|END_ENTITY	Spontaneous in vivo gene transcription of interleukin-2 , interleukin-3 , interleukin-4 , interleukin-6 , _ interferon-gamma , _ interleukin-2_receptor -LRB- CD25 -RRB- and proto-oncogene_c-myc by rheumatoid synovial T lymphocytes .
15507389	0	interleukin-2	66,79	CD25	124,128	interleukin-2	CD25	3558	3559	Gene	Gene	analog|compound|START_ENTITY BAY_50-4798|appos|analog induces|nsubj|BAY_50-4798 induces|dobj|increases increases|nmod|expression expression|compound|END_ENTITY	BAY_50-4798 , a novel , high-affinity receptor-specific recombinant interleukin-2 analog , induces dose-dependent increases in CD25 expression and proliferation among unstimulated , human peripheral blood mononuclear cells in vitro .
1571333	0	interleukin-2	25,38	CD25	6,10	interleukin-2	CD25	3558	3559	Gene	Gene	therapy|compound|START_ENTITY levels|nmod|therapy levels|compound|END_ENTITY	Serum CD25 levels during interleukin-2 therapy : dose dependence and correlations with clinical toxicity and lymphocyte surface sCD25 expression .
16505437	0	interleukin-2	84,97	CD25	24,28	interleukin-2	CD25	3558	3559	Gene	Gene	treated|nmod|START_ENTITY patients|acl|treated +|nmod|patients +|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of CD4 + CD25 + regulatory T cells in patients treated with high-dose interleukin-2 for metastatic_melanoma or renal_cell_carcinoma .
1667947	0	interleukin-2	72,85	CD25	87,91	interleukin-2	CD25	3558	3559	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Evaluation of lymphocyte activation by flow cytometric determination of interleukin-2 -LRB- CD25 -RRB- receptor .
22851544	0	interleukin-2	22,35	CD25	97,101	interleukin-2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	therapy|nmod|START_ENTITY therapy|parataxis|expands expands|ccomp|+ +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	Cytokine therapy with interleukin-2 / anti-interleukin-2 monoclonal antibody complexes expands CD4 + CD25 + Foxp3 + regulatory T cells and attenuates development and progression of atherosclerosis .
2896111	0	interleukin-2	178,191	CD25	203,207	interleukin-2	CD25	3558	3559	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Cyclosporin_A does not inhibit the PHA-stimulated increase in intracellular Ca2 + concentration but inhibits the increase in E-rosette receptor -LRB- CD2 -RRB- expression and appearance of interleukin-2 receptors -LRB- CD25 -RRB- .
3128947	0	interleukin-2	18,31	CD25	54,58	interleukin-2	CD25	3558	3559	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|appos|END_ENTITY	Expression of the interleukin-2 receptor -LRB- Tac_antigen / CD25 -RRB- in hematologic_neoplasms .
7570988	0	interleukin-2	31,44	CD25	55,59	interleukin-2	CD25	3558	3559	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Prolonged action of a chimeric interleukin-2 receptor -LRB- CD25 -RRB- monoclonal antibody used in cadaveric renal transplantation .
7619228	0	interleukin-2	93,106	CD25	12,16	interleukin-2	CD25	3558	3559	Gene	Gene	receptor|compound|START_ENTITY down-regulated|nmod|receptor down-regulated|nmod|+ +|compound|END_ENTITY	In vivo CD3 + CD25 + lymphocyte subpopulation is down-regulated without increased serum-soluble interleukin-2 receptor -LRB- sIL-2R -RRB- by gonadotropin releasing hormone agonist -LRB- GnRH-a -RRB- .
8050452	0	interleukin-2	96,109	CD25	120,124	interleukin-2	CD25	3558	3559	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Dietary supplementation with very long-chain n-3 fatty_acids in man decreases expression of the interleukin-2 receptor -LRB- CD25 -RRB- on mitogen-stimulated lymphocytes from patients with inflammatory skin_diseases .
9111583	0	interleukin-2	14,27	CD25	38,42	interleukin-2	CD25	3558	3559	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of interleukin-2 receptor -LRB- CD25 -RRB- expression induced on T cells from children with acute_lymphoblastic_leukemia .
1650350	0	interleukin-2	14,27	CD28	79,83	interleukin-2	CD28	3558	940	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element .
1846244	0	interleukin-2	14,27	CD28	84,88	interleukin-2	CD28	3558	940	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene enhancer|nsubj|Regulation enhancer|nmod|END_ENTITY	Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28 .
7821964	0	interleukin-2	80,93	CD28	13,17	interleukin-2	CD28	3558	940	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Influence Influence|nmod|co-stimulation co-stimulation|nummod|END_ENTITY	Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2 .
8164687	0	interleukin-2	85,98	CD28	26,30	interleukin-2	CD28	3558	940	Gene	Gene	secretion|compound|START_ENTITY costimulation|nmod|secretion necessary|nmod|costimulation necessary|nsubj|domain domain|nmod|END_ENTITY	The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3 ' - kinase .
8626528	0	interleukin-2	118,131	CD28	46,50	interleukin-2	CD28	3558	940	Gene	Gene	production|compound|START_ENTITY correlates|nmod|production correlates|nsubj|appearance appearance|nmod|factor factor|acl:relcl|binds binds|dobj|element element|compound|END_ENTITY	Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production .
8626528	0	interleukin-2	79,92	CD28	46,50	interleukin-2	CD28	3558	940	Gene	Gene	enhancer|compound|START_ENTITY element|nmod|enhancer element|compound|END_ENTITY	Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production .
9199340	0	interleukin-2	50,63	CD28	0,4	interleukin-2	CD28	3558	940	Gene	Gene	promoter|compound|START_ENTITY upregulation|nmod|promoter mediates|dobj|upregulation mediates|nsubj|END_ENTITY	CD28 mediates transcriptional upregulation of the interleukin-2 -LRB- IL-2 -RRB- promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites .
9417115	0	interleukin-2	34,47	CD28	48,52	interleukin-2	CD28	3558	940	Gene	Gene	transactivation|nmod|START_ENTITY END_ENTITY|nsubj|transactivation	Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1 / CREB2 .
9850868	0	interleukin-2	24,37	CD28	52,56	interleukin-2	CD28	3558	940	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy .
18214800	0	interleukin-2	9,22	CD3	86,89	interleukin-2	CD3	16183(Tax:10090)	12501(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Impaired interleukin-2 synthesis and T cell proliferation following antibody-mediated CD3 and CD2 or CD28 cross-linking in trans : evidence that T cell activation requires the engagement of costimulatory molecules within the immunological synapse .
10197373	0	interleukin-2	99,112	CD4	42,45	interleukin-2	CD4	3558	920	Gene	Gene	treated|nmod|START_ENTITY patients|acl|treated lymphocytes|nmod|patients lymphocytes|nsubj|upregulation upregulation|nmod|expression expression|nmod|T T|compound|END_ENTITY	Acute upregulation of CCR-5 expression by CD4 + T lymphocytes in HIV-infected patients treated with interleukin-2 .
10233698	0	interleukin-2	39,52	CD4	67,70	interleukin-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY production|nmod|T T|compound|END_ENTITY	Inhibitory effect of interleukin-16 on interleukin-2 production by CD4 + T cells .
10353861	0	interleukin-2	34,47	CD4	132,135	interleukin-2	CD4	3558	920	Gene	Gene	START_ENTITY|xcomp|treat treat|advcl|< <|ccomp|cells cells|compound|END_ENTITY	Efficacy of low-dose subcutaneous interleukin-2 to treat advanced human_immunodeficiency_virus_type_1 in persons with < / = 250/microL CD4 T cells and undetectable plasma virus load .
10479131	0	interleukin-2	22,35	CD4	50,53	interleukin-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Restoration of normal interleukin-2 production by CD4 + T cells of human_immunodeficiency_virus-infected patients after 9 months of highly active antiretroviral therapy .
10823761	0	interleukin-2	84,97	CD4	203,206	interleukin-2	CD4	3558	920	Gene	Gene	comparing|nmod|START_ENTITY comparing|dep|> >|nmod|patients patients|nmod|counts counts|compound|END_ENTITY	A randomized , controlled , phase II trial comparing escalating doses of subcutaneous interleukin-2 plus antiretrovirals versus antiretrovirals alone in human_immunodeficiency_virus-infected patients with CD4 + cell counts > / = 350/mm3 .
11181149	0	interleukin-2	16,29	CD4	94,97	interleukin-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY therapy|acl:relcl|counts counts|nsubj|cell cell|compound|END_ENTITY	Rapid effect of interleukin-2 therapy in human_immunodeficiency_virus-infected patients whose CD4 cell counts increase only slightly in response to combined antiretroviral treatment .
11182148	0	interleukin-2	155,168	CD4	39,42	interleukin-2	CD4	396868(Tax:9823)	404704(Tax:9823)	Gene	Gene	vitro|nmod|START_ENTITY generated|advcl|vitro phenotype|acl|generated lymphoblastoid|nmod|phenotype characterization|parataxis|lymphoblastoid characterization|nmod|END_ENTITY	Functional characterization of a swine CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- double positive lymphoblastoid T-cell line with a CD25 -LRB- + -RRB- / CD45RA -LRB- - -RRB- phenotype generated in vitro with interleukin-2 .
12383198	0	interleukin-2	13,26	CD4	51,54	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Insufficient interleukin-2 production from splenic CD4 + T cells causes impaired cell proliferation and early apoptosis in SAMP1 , a strain of senescence-accelerated mouse .
12706405	0	interleukin-2	139,152	CD4	255,258	interleukin-2	CD4	3558	920	Gene	Gene	cycles|nmod|START_ENTITY combined|nsubj|cycles combined|nmod|patients patients|nmod|cells cells|compound|END_ENTITY	A randomized controlled trial evaluating the efficacy and safety of intermittent 3 - , 4 - , and 5-day cycles of intravenous recombinant human interleukin-2 combined with antiretroviral therapy -LRB- ART -RRB- versus ART alone in HIV-seropositive patients with 100-300 CD4 + T cells .
1370094	0	interleukin-2	139,152	CD4	2,5	interleukin-2	CD4	3558	920	Gene	Gene	activity|nmod|START_ENTITY clone|dep|activity clone|compound|END_ENTITY	A CD4 + cytotoxic T-lymphocyte clone to a conserved epitope on human_immunodeficiency_virus_type_1 p24 : cytotoxic activity and secretion of interleukin-2 and interleukin-6 .
14512540	0	interleukin-2	109,122	CD4	66,69	interleukin-2	CD4	3558	920	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|proliferation proliferation|nmod|cells cells|compound|END_ENTITY	Diminished proliferation of human_immunodeficiency_virus-specific CD4 + T cells is associated with diminished interleukin-2 -LRB- IL-2 -RRB- production and is recovered by exogenous IL-2 .
14523786	0	interleukin-2	70,83	CD4	6,9	interleukin-2	CD4	3558	920	Gene	Gene	predicts|nmod|START_ENTITY predicts|nsubj|count count|compound|END_ENTITY	Nadir CD4 + T cell count predicts response to subcutaneous recombinant interleukin-2 .
14600575	0	interleukin-2	106,119	CD4	13,16	interleukin-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY receiving|dobj|therapy occur|advcl|receiving occur|nsubj|Increases Increases|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Increases in CD4 + T lymphocytes occur without increases in thymic size in HIV-infected subjects receiving interleukin-2 therapy .
14612896	0	interleukin-2	120,133	CD4	174,177	interleukin-2	CD4	3558	920	Gene	Gene	OK-432|nmod|START_ENTITY using|dobj|OK-432 colorectal_cancer|acl|using effusion|nmod|colorectal_cancer immunotherapy|nmod|effusion immunotherapy|dep|induction induction|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Locoregional immunotherapy of malignant effusion from colorectal_cancer using the streptococcal preparation OK-432 plus interleukin-2 : induction of autologous tumor-reactive CD4 + Th1 killer lymphocytes .
15493262	0	interleukin-2	59,72	CD4	76,79	interleukin-2	CD4	3558	920	Gene	Gene	production|nmod|START_ENTITY Maximal|dobj|production Maximal|nmod|CDw29 CDw29|compound|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
15753210	0	interleukin-2	19,32	CD4	37,40	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Essential role for interleukin-2 for CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T regulatory cell development during the neonatal period .
16320325	0	interleukin-2	86,99	CD4	6,9	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|T T|compound|END_ENTITY	Acute CD4 + T lymphocyte-dependent interleukin-1-driven arthritis selectively requires interleukin-2 and interleukin-4 , joint macrophages , granulocyte-macrophage_colony-stimulating_factor , interleukin-6 , and leukemia_inhibitory_factor .
16505437	0	interleukin-2	84,97	CD4	20,23	interleukin-2	CD4	3558	920	Gene	Gene	treated|nmod|START_ENTITY patients|acl|treated +|nmod|patients +|nsubj|Characterization Characterization|nmod|CD25 CD25|compound|END_ENTITY	Characterization of CD4 + CD25 + regulatory T cells in patients treated with high-dose interleukin-2 for metastatic_melanoma or renal_cell_carcinoma .
16522809	0	interleukin-2	76,89	CD4	14,17	interleukin-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY function|nmod|production function|nsubj|Inhibition Inhibition|nmod|T-cell T-cell|compound|END_ENTITY	Inhibition of CD4 + CD25 + regulatory T-cell function by calcineurin-dependent interleukin-2 production .
17484770	0	interleukin-2	36,49	CD4	105,108	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY enhances|nmod|production enhances|nmod|cells cells|compound|END_ENTITY	Lipopolysaccharide enhances in vivo interleukin-2 production and proliferation by naive antigen-specific CD4 T cells via a Toll-like_receptor_4-dependent mechanism .
18281483	0	interleukin-2	24,37	CD4	82,85	interleukin-2	CD4	3558	920	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|cells cells|amod|interleukin-21 interleukin-21|nmod|+ +|compound|END_ENTITY	Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4 + cutaneous_T-cell_lymphoma cells .
22002241	0	interleukin-2	13,26	CD4	56,59	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|drives drives|dep|+ +|compound|END_ENTITY	Intratumoral interleukin-2 / agonist CD40 antibody drives CD4 + - independent resolution of treated-tumors and CD4 + - dependent systemic and memory responses .
22301410	0	interleukin-2	23,36	CD4	48,51	interleukin-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|T-cell T-cell|compound|END_ENTITY	Effect of intermittent interleukin-2 therapy on CD4 + T-cell counts following antiretroviral cessation in patients with HIV .
22445722	0	interleukin-2	19,32	CD4	47,50	interleukin-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Down-regulation of interleukin-2 production by CD4 -LRB- + -RRB- T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription .
22851544	0	interleukin-2	22,35	CD4	93,96	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	therapy|nmod|START_ENTITY therapy|parataxis|expands expands|ccomp|+ +|nsubj|Foxp3 Foxp3|compound|END_ENTITY	Cytokine therapy with interleukin-2 / anti-interleukin-2 monoclonal antibody complexes expands CD4 + CD25 + Foxp3 + regulatory T cells and attenuates development and progression of atherosclerosis .
24853588	0	interleukin-2	51,64	CD4	79,82	interleukin-2	CD4	116562(Tax:10116)	24932(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Decreased c-rel activation contributes to aberrant interleukin-2 expression in CD4 -LRB- + -RRB- T cells of aged rats .
2572284	0	interleukin-2	84,97	CD4	161,164	interleukin-2	CD4	3558	920	Gene	Gene	synthesize|dobj|START_ENTITY synthesize|nmod|END_ENTITY	T-cell ontogeny after autologous bone marrow transplantation : failure to synthesize interleukin-2 -LRB- IL-2 -RRB- and lack of CD2 - and CD3-mediated proliferation by both CD4 - and CD8 + cells even in the presence of exogeneous IL-2 .
2574630	0	interleukin-2	146,159	CD4	42,45	interleukin-2	CD4	3558	920	Gene	Gene	presence|nmod|START_ENTITY contain|nmod|presence contain|dobj|cells cells|compound|END_ENTITY	Cancer patients ' lymphocytes contain CD3 + CD4 + cells that proliferate in response to autologous tumor cells in the presence of exogenous low-dose interleukin-2 and autologous accessory cells .
2904172	0	interleukin-2	13,26	CD4	41,44	interleukin-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Induction of interleukin-2 production in CD4 + and CD8 + T-cell subsets after activation via CD3 and CD2 .
3100439	0	interleukin-2	10,23	CD4	73,76	interleukin-2	CD4	3558	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|lymphocytes lymphocytes|amod|END_ENTITY	Increased interleukin-2 receptor expression after mitogen stimulation on CD4 - and CD8-positive lymphocytes and decreased interleukin-2 production in HTLV-III antibody-positive symptomatic individuals .
7646637	0	interleukin-2	60,73	CD4	13,16	interleukin-2	CD4	3558	920	Gene	Gene	courses|nmod|START_ENTITY lymphocytes|nmod|courses lymphocytes|nsubj|Increases Increases|nmod|T T|compound|END_ENTITY	Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human_immunodeficiency_virus_infection .
7676498	0	interleukin-2	43,56	CD4	153,156	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	graft-versus-host_disease|nmod|START_ENTITY treatment|amod|graft-versus-host_disease Inhibition|nmod|treatment associated|nsubjpass|Inhibition associated|nmod|cells cells|amod|graft-versus-host-reactive graft-versus-host-reactive|dep|END_ENTITY	Inhibition of graft-versus-host_disease by interleukin-2 treatment is associated with altered cytokine production by expanded graft-versus-host-reactive CD4 + helper cells .
7901231	0	interleukin-2	8,21	CD4	111,114	interleukin-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY due|nsubj|production due|nmod|abnormality abnormality|nmod|differentiation differentiation|compound|END_ENTITY	Reduced interleukin-2 -LRB- IL-2 -RRB- production in common variable immunodeficiency is due to a primary abnormality of CD4 + T cell differentiation .
7905789	0	interleukin-2	97,110	CD4	15,18	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY augments|dobj|action augments|nsubj|Elimination Elimination|nmod|cells cells|nummod|END_ENTITY	Elimination of CD4 + T cells in mice bearing an advanced sarcoma augments the antitumor action of interleukin-2 .
8088331	0	interleukin-2	53,66	CD4	139,142	interleukin-2	CD4	3558	920	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	A 150-kDa molecule of macrophage membrane stimulates interleukin-2 and interferon-gamma production and proliferation of ovalbumin-specific CD4 + T cells .
8103719	0	interleukin-2	14,27	CD4	130,133	interleukin-2	CD4	3558	920	Gene	Gene	synthesis|compound|START_ENTITY Inhibition|nmod|synthesis Inhibition|acl|derived derived|nmod|clone clone|nummod|+ +|compound|END_ENTITY	Inhibition of interleukin-2 synthesis and interleukin-2_receptor_alpha expression on T cells by a cell-free factor derived from a CD4 + regulatory T cell clone .
8104885	0	interleukin-2	16,29	CD4	116,119	interleukin-2	CD4	116562(Tax:10116)	24932(Tax:10116)	Gene	Gene	production|compound|START_ENTITY Dissociation|nmod|production Dissociation|nmod|cells cells|compound|END_ENTITY	Dissociation of interleukin-2 production from the cell activation in response to the mitogenic lectin in peripheral CD4 + T cells of LEC mutant rats .
8110726	0	interleukin-2	95,108	CD4	127,130	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|functions functions|compound|END_ENTITY	Strain dependence of interleukin-2-induced graft-versus-host_disease protection : evidence that interleukin-2 inhibits selected CD4 functions .
8500265	0	interleukin-2	36,49	CD4	121,124	interleukin-2	CD4	3558	920	Gene	Gene	production|nmod|START_ENTITY correlated|nsubjpass|production correlated|nmod|number number|acl|circulating circulating|dobj|cells cells|nummod|END_ENTITY	The impaired in vitro production of interleukin-2 in HIV_infection is negatively correlated to the number of circulating CD4 + DR + T cells and is reversed by allowing T cells to rest in culture : arguments for in vivo CD4 + T cell activation .
8814276	0	interleukin-2	87,100	CD4	151,154	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|responses responses|nmod|cells cells|compound|END_ENTITY	Induction of sensitivity to activation-induced_death in primary CD4 + cells : a role for interleukin-2 in the negative regulation of responses by mature CD4 + T cells .
8814276	0	interleukin-2	87,100	CD4	64,67	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Induction|dep|role Induction|nmod|sensitivity sensitivity|nmod|activation-induced_death activation-induced_death|nmod|cells cells|compound|END_ENTITY	Induction of sensitivity to activation-induced_death in primary CD4 + cells : a role for interleukin-2 in the negative regulation of responses by mature CD4 + T cells .
8844341	0	interleukin-2	46,59	CD4	97,100	interleukin-2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|melatonin melatonin|nmod|patients patients|nmod|number number|compound|END_ENTITY	Neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin in AIDS patients with CD4 cell number below 200/mm3 : a biological phase-II study .
9054522	0	interleukin-2	65,78	CD4	86,89	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Irradiated NC adenocarcinoma cells transduced with both B7 .1 and interleukin-2 induce CD4 + - mediated rejection of established tumors .
9278942	0	interleukin-2	23,36	CD4	89,92	interleukin-2	CD4	708017(Tax:9544)	713807(Tax:9544)	Gene	Gene	production|compound|START_ENTITY production|nmod|+ +|compound|END_ENTITY	Blastogenic responses , interleukin-2 production and interleukin-2 receptor expression on CD4 + and CD8 + lymphocytes in rhesus_monkeys experimentally inoculated with Loa_loa .
9301525	0	interleukin-2	37,50	CD4	15,18	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Enhancement of CD4 + T-cell-dependent interleukin-2 production in vitro by murine alveolar macrophages : the role of leukotriene B4 .
9389737	0	interleukin-2	24,37	CD4	49,52	interleukin-2	CD4	3558	920	Gene	Gene	therapy|compound|START_ENTITY therapy|nmod|subsets subsets|nummod|END_ENTITY	Effects of subcutaneous interleukin-2 therapy on CD4 subsets and in vitro cytokine production in HIV + subjects .
9551948	0	interleukin-2	84,97	CD4	58,61	interleukin-2	CD4	3558	920	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion cells|acl:relcl|inhibits cells|compound|END_ENTITY	CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X -LRB- L -RRB- induction .
9831181	0	interleukin-2	130,143	CD4	35,38	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY +|nmod|absence +|nsubj|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
9831181	0	interleukin-2	53,66	CD4	35,38	interleukin-2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY +|nmod|mice +|nsubj|END_ENTITY	In vitro skewing of TCR transgenic CD4 + T cells from interleukin-2 deficient mice towards Th1 and Th2 in the absence of exogenous interleukin-2 .
10561318	0	interleukin-2	114,127	CD8	44,47	interleukin-2	CD8	3558	925	Gene	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|trial trial|nmod|tumor-infiltrating tumor-infiltrating|compound|END_ENTITY	Multicenter , randomized , phase III trial of CD8 -LRB- + -RRB- tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal_cell_carcinoma .
11477316	0	interleukin-2	82,95	CD8	131,134	interleukin-2	CD8	3558	925	Gene	Gene	inhibition|compound|START_ENTITY analysis|nmod|inhibition using|dobj|analysis using|nmod|END_ENTITY	Quantitation of immunosuppression by tacrolimus using flow cytometric analysis of interleukin-2 and interferon-gamma inhibition in CD8 -LRB- - -RRB- and CD8 -LRB- + -RRB- peripheral blood T cells .
1533853	0	interleukin-2	61,74	CD8	45,48	interleukin-2	CD8	3558	925	Gene	Gene	T|nmod|START_ENTITY T|nsubj|Modulation Modulation|nmod|receptors receptors|nmod|+ +|compound|END_ENTITY	Modulation of histamine type II receptors on CD8 + T cells by interleukin-2 and cimetidine .
1900952	0	interleukin-2	78,91	CD8	18,21	interleukin-2	CD8	3558	925	Gene	Gene	production|compound|START_ENTITY absence|nmod|production cytolysis|nmod|absence anergy|dep|cytolysis anergy|nmod|cell cell|compound|END_ENTITY	Split anergy in a CD8 + T cell : receptor-dependent cytolysis in the absence of interleukin-2 production .
1902247	0	interleukin-2	94,107	CD8	144,147	interleukin-2	CD8	3558	925	Gene	Gene	receptors|compound|START_ENTITY levels|nmod|receptors levels|nmod|protein protein|compound|END_ENTITY	Immune cell activation in melioidosis : increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein .
20795538	0	interleukin-2	12,25	CD8	36,39	interleukin-2	CD8	3558	925	Gene	Gene	role|nmod|START_ENTITY role|nmod|differentiation differentiation|nummod|END_ENTITY	The role of interleukin-2 in memory CD8 cell differentiation .
21594368	0	interleukin-2	85,98	CD8	35,38	interleukin-2	CD8	3558	925	Gene	Gene	immunotherapy|nmod|START_ENTITY lymphocytes|nmod|immunotherapy lymphocytes|nsubj|expansion expansion|acl|circulating circulating|dobj|+ +|compound|END_ENTITY	Selective expansion of circulating CD8 + lymphocytes during cancer immunotherapy with interleukin-2 plus alpha-interferon but not with interleukin-2 alone .
24887424	0	interleukin-2	95,108	CD8	112,115	interleukin-2	CD8	3558	925	Gene	Gene	START_ENTITY|nmod|T-cells T-cells|compound|END_ENTITY	Rejection quantity in kidney transplant recipients is associated with increasing intracellular interleukin-2 in CD8 + T-cells .
7890312	0	interleukin-2	57,70	CD8	81,84	interleukin-2	CD8	3558	925	Gene	Gene	activities|nmod|START_ENTITY interleukin-10|nmod|activities T|amod|interleukin-10 T|compound|END_ENTITY	Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts .
8556489	0	interleukin-2	103,116	CD8	83,86	interleukin-2	CD8	3558	925	Gene	Gene	deoxythymidine|nmod|START_ENTITY deoxythymidine|nmod|responsiveness responsiveness|nmod|lymphocytes lymphocytes|nummod|+ +|compound|END_ENTITY	Inhibitory effect of 3 ' - azido-3 ' - deoxythymidine on proliferative responsiveness of CD8 + lymphocytes to interleukin-2 .
10697557	0	interleukin-2	10,23	CD95	27,31	interleukin-2	CD95	3558	355	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of interleukin-2 on CD95 -LRB- Fas/APO -1 -RRB- expression in fresh chronic_lymphocytic_leukaemia and mantle_cell_lymphoma cells : relationship to ex vivo chemoresponse .
7653683	0	interleukin-2	27,40	CSF	13,16	interleukin-2	CSF	3558	1437	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Increases in CSF levels of interleukin-2 in schizophrenia : effects of recurrence of psychosis and medication status .
8102512	0	interleukin-2	23,36	CSF	9,12	interleukin-2	CSF	3558	1437	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients .
8258320	0	interleukin-2	47,60	Cyclosporin_A	0,13	interleukin-2	Cyclosporin A	3558	1442	Gene	Gene	synthesis|compound|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Cyclosporin_A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein_kinase_C_isoenzyme , _ protein_kinase_C-beta .
10640296	0	interleukin-2	89,102	EL4	139,142	interleukin-2	EL4	16183(Tax:10090)	111979(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|acl|transcription transcription|nmod|cannabinol cannabinol|nmod|T-cells T-cells|compound|END_ENTITY	Role of nuclear factor of activated T-cells and activator_protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells .
8136944	0	interleukin-2	14,27	EL4	31,34	interleukin-2	EL4	16183(Tax:10090)	111979(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Production of interleukin-2 by EL4 tumor cells induces natural killer cell - and T-cell-mediated immunity .
15031210	0	interleukin-2	83,96	GILZ	0,4	interleukin-2	GILZ	16183(Tax:10090)	14605(Tax:10090)	Gene	Gene	apoptosis|amod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	GILZ , a new target for the transcription factor FoxO3 , protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis .
2323107	0	interleukin-2	30,43	HLA-DP	0,6	interleukin-2	HLA-DP	3558	3115	Gene	Gene	START_ENTITY|nsubj|cells cells|compound|END_ENTITY	HLA-DP + T cells and deficient interleukin-2 production in patients with systemic_lupus_erythematosus .
25210803	0	interleukin-2	92,105	ICOS_ligand	121,132	interleukin-2	ICOS ligand	3558	102723996	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS_ligand .
15806975	0	interleukin-2	121,134	IFN-gamma	68,77	interleukin-2	IFN-gamma	3558	3458	Gene	Gene	START_ENTITY|nsubj|efficacy efficacy|appos|interferon-gamma interferon-gamma|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
10207608	0	interleukin-2	102,115	IL-2	117,121	interleukin-2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Phospholipase_A2 inhibitors p-bromophenacyl_bromide and arachidonyl_trifluoromethyl_ketone suppressed interleukin-2 -LRB- IL-2 -RRB- expression in murine primary splenocytes .
11809870	0	interleukin-2	26,39	IL-2	41,45	interleukin-2	IL-2	3558	3558	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cannabinol enhancement of interleukin-2 -LRB- IL-2 -RRB- expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity .
1345742	0	interleukin-2	15,28	IL-2	30,34	interleukin-2	IL-2	3558	3558	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	On the role of interleukin-2 -LRB- IL-2 -RRB- in multiple_sclerosis -LRB- MS -RRB- .
15806975	0	interleukin-2	121,134	IL-2	135,139	interleukin-2	IL-2	3558	3558	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
1698421	0	interleukin-2	11,24	IL-2	26,30	interleukin-2	IL-2	3558	3558	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of interleukin-2 -LRB- IL-2 -RRB- on human plasma lipid , lipoprotein , and C-reactive_protein .
2009236	0	interleukin-2	67,80	IL-2	91,95	interleukin-2	IL-2	3558	3558	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	Blood_coagulation_abnormalities during adoptive immunotherapy with interleukin-2 -LRB- r-Met Hu IL-2 -LSB- ala 125 -RSB- -RRB- .
20544350	0	interleukin-2	24,37	IL-2	39,43	interleukin-2	IL-2	3558	3558	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Antiapoptotic effect of interleukin-2 -LRB- IL-2 -RRB- in B-CLL cells with low and high affinity IL-2 receptors .
2420701	0	interleukin-2	22,35	IL-2	37,41	interleukin-2	IL-2	3558	3558	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|appos|END_ENTITY	Inactivation of human interleukin-2 -LRB- IL-2 -RRB- by alpha 2-macroglobulin-trypsin complexes .
2474592	0	interleukin-2	31,44	IL-2	46,50	interleukin-2	IL-2	3558	3558	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Allergen-specific induction of interleukin-2 -LRB- IL-2 -RRB- responsiveness in lymphocytes from children with asthma .
2787749	0	interleukin-2	43,56	IL-2	67,71	interleukin-2	IL-2	3558	3558	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	Tolerance and effectiveness of recombinant interleukin-2 -LRB- r-met Hu IL-2 -LSB- ala-125 -RSB- -RRB- and lymphokine-activated killer cells in patients with metastatic solid_tumors .
2788180	0	interleukin-2	31,44	IL-2	46,50	interleukin-2	IL-2	3558	3558	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Allergen-specific induction of interleukin-2 -LRB- IL-2 -RRB- responsiveness in lymphocytes from children with asthma .
6609855	0	interleukin-2	23,36	IL-2	38,42	interleukin-2	IL-2	3558	3558	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Decreased synthesis of interleukin-2 -LRB- IL-2 -RRB- in insulin-dependent_diabetes_mellitus .
7591233	0	interleukin-2	8,21	IL-2	23,27	interleukin-2	IL-2	3558	3558	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lack of interleukin-2 -LRB- IL-2 -RRB- expression and selective expression of IL-10 mRNA in human renal_cell_carcinoma .
7621867	0	interleukin-2	36,49	IL-2	52,56	interleukin-2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Non random activation of endogenous interleukin-2 , -LRB- IL-2 -RRB- , IL-2_receptor alpha and IL-2_receptor beta genes after transfection of mouse fibroblasts with a cDNA for the alpha chain of the human IL-2_receptor .
7907273	0	interleukin-2	48,61	IL-2	79,83	interleukin-2	IL-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Progression mechanisms in colon_cancer : soluble interleukin-2 -LRB- IL-2 -RRB- _ receptor , IL-2 plus anti-CD3 proliferative response and tumour stage correlations .
8294403	0	interleukin-2	43,56	IL-2	58,62	interleukin-2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The adapter protein Shc interacts with the interleukin-2 -LRB- IL-2 -RRB- receptor upon IL-2 stimulation .
8423463	0	interleukin-2	24,37	IL-2	50,54	interleukin-2	IL-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	In vivo relationship of interleukin-2 and soluble IL-2 receptor to blood-brain barrier_impairment in patients with active multiple_sclerosis .
8831171	0	interleukin-2	16,29	IL-2	31,35	interleukin-2	IL-2	3558	3558	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	-LSB- Correlation of interleukin-2 -LRB- IL-2 -RRB- responsiveness by egg white-stimulated lymphocytes with hen egg oral provocation test in atopic children -RSB- .
12231477	0	interleukin-2	69,82	IL-2Ralpha	43,53	interleukin-2	IL-2Ralpha	3558	3559	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
12649439	0	interleukin-2	24,37	IL-2Ralpha	60,70	interleukin-2	IL-2Ralpha	3558	3559	Gene	Gene	START_ENTITY|nmod|complexes complexes|nmod|component component|compound|END_ENTITY	NMR characterization of interleukin-2 in complexes with the IL-2Ralpha receptor component , and with low molecular weight compounds that inhibit the IL-2 / IL-Ralpha interaction .
2279527	0	interleukin-2	23,36	IL2	37,40	interleukin-2	IL2	3558	3558	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Impaired production of interleukin-2 -LRB- IL2 -RRB- in patients with Graves ' _ disease by newly developed IL2 radioimmunoassay .
8222752	0	interleukin-2	36,49	IL2	51,54	interleukin-2	IL2	280822(Tax:9913)	280822(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regional localization of the bovine interleukin-2 -LRB- IL2 -RRB- gene to chromosome 17q22 -- > q23 by in situ hybridization .
1637783	0	interleukin-2	58,71	Interferon-gamma	0,16	interleukin-2	Interferon-gamma	3558	3458	Gene	Gene	administration|nmod|START_ENTITY induced|nmod|administration induced|nsubj|END_ENTITY	Interferon-gamma induced by administration of recombinant interleukin-2 to patients with cancer : kinetics , dose dependence , and correlation with physiological and therapeutic response .
19514839	0	interleukin-2	101,114	Interferon-gamma	0,16	interleukin-2	Interferon-gamma	3558	3458	Gene	Gene	vitro|nmod|START_ENTITY induced|advcl|vitro induced|nsubjpass|END_ENTITY	Interferon-gamma is induced in human peripheral blood immune cells in vitro by sodium_stibogluconate / interleukin-2 and mediates its antitumor activity in vivo .
1533388	0	interleukin-2	124,137	Interleukin-1	0,13	interleukin-2	Interleukin-1	3558	3552	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Interleukin-1 down-regulates gene and surface expression of interleukin-1_receptor_type_I by destabilizing its mRNA whereas interleukin-2 increases its expression .
9176231	0	interleukin-2	74,87	Interleukin-15	0,14	interleukin-2	Interleukin-15	3558	3600	Gene	Gene	beta-chain|compound|START_ENTITY absence|nmod|beta-chain cells|nmod|absence signals|dobj|cells signals|nsubj|END_ENTITY	Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain .
23167249	0	interleukin-2	128,141	Interleukin-2	0,13	interleukin-2	Interleukin-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY suppresses|nmod|pathways END_ENTITY|parataxis|suppresses	Interleukin-2 / anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced_arthritis in mice by fortifying interleukin-2 / STAT5 signalling pathways .
3311208	0	interleukin-2	41,54	Interleukin-2	0,13	interleukin-2	Interleukin-2	3558	3558	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Interleukin-2 production and response to interleukin-2 by peripheral blood mononuclear cells from patients after bone marrow transplantation : II .
7774310	0	interleukin-2	26,39	Interleukin-2	0,13	interleukin-2	Interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Interleukin-2 and soluble interleukin-2 receptor in bronchoalveolar lavage fluid from patients with bronchial_asthma .
8490104	0	interleukin-2	26,39	Interleukin-2	0,13	interleukin-2	Interleukin-2	3558	3558	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Interleukin-2 and soluble interleukin-2 receptor levels in children with active pulmonary_tuberculosis and atypical mycobacterial adenitis .
8280711	0	interleukin-2	64,77	Interleukin-3	0,13	interleukin-2	Interleukin-3	3558	3562	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-3 inhibits the generation of nonspecific killers by interleukin-2 .
14871295	0	interleukin-2	35,48	Interleukin-4	0,13	interleukin-2	Interleukin-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Interleukin-4 selectively inhibits interleukin-2 secretion by lipopolysaccharide-activated dendritic cells .
1715237	0	interleukin-2	31,44	Interleukin-6	0,13	interleukin-2	Interleukin-6	3558	3569	Gene	Gene	generation|compound|START_ENTITY support|dobj|generation support|nsubj|END_ENTITY	Interleukin-6 does not support interleukin-2 induced generation of human lymphokine-activated killer cells .
8277774	0	interleukin-2	62,75	Interleukin-8	0,13	interleukin-2	Interleukin-8	16183(Tax:10090)	20309(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY suppresses|dobj|effect suppresses|nsubj|END_ENTITY	Interleukin-8 suppresses the toxicity and antitumor effect of interleukin-2 .
9130632	0	interleukin-2	69,82	Itk	0,3	interleukin-2	Itk	3558	3702	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Itk , a T cell-specific tyrosine kinase , is required for CD2-mediated interleukin-2 promoter activation in the human T cell line Jurkat .
2563135	0	interleukin-2	33,46	LAK	63,66	interleukin-2	LAK	3558	80216	Gene	Gene	therapy|compound|START_ENTITY Hypothyroidism|nmod|therapy Hypothyroidism|nmod|cells cells|compound|END_ENTITY	Hypothyroidism and goitre during interleukin-2 therapy without LAK cells .
3264344	0	interleukin-2	148,161	LAK	87,90	interleukin-2	LAK	3558	80216	Gene	Gene	dose|nmod|START_ENTITY generated|nmod|dose cell|acl|generated cell|compound|END_ENTITY	Fractionated extract of Astragalus membranaceus , a Chinese medicinal herb , potentiates LAK cell cytotoxicity generated by a low dose of recombinant interleukin-2 .
7754446	0	interleukin-2	20,33	LAK	48,51	interleukin-2	LAK	3558	80216	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	-LSB- Immunotherapy with interleukin-2 and allogenic LAK cells in a patient with acute_myeloblastic_leukemia -RSB- .
10903801	0	interleukin-2	19,32	Lck	0,3	interleukin-2	Lck	3558	3932	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Lck is involved in interleukin-2 induced proliferation but not cell survival in human T cells through a MAP kinase-independent pathway .
6978826	0	interleukin-2	12,25	Lymphokine	0,10	interleukin-2	Lymphokine	3558	3558	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Lymphokine -LRB- interleukin-2 -RRB- production by mitogen-stimulated human lymphocytes in small reactors .
11287617	0	interleukin-2	144,157	NFAT	127,131	interleukin-2	NFAT	3558	4773	Gene	Gene	promoter|compound|START_ENTITY site|nmod|promoter site|compound|END_ENTITY	Vav-Rac1-mediated activation of the c-Jun_N-terminal_kinase / c-Jun/AP -1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter .
10196292	0	interleukin-2	76,89	Nef	0,3	interleukin-2	Nef	3558	6285	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo .
12130739	0	interleukin-2	10,23	P-glycoprotein	38,52	interleukin-2	P-glycoprotein	16183(Tax:10090)	67078(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of interleukin-2 on intestinal P-glycoprotein expression and functionality in mice .
3128500	0	interleukin-2	18,31	PSK	11,14	interleukin-2	PSK	3558	9344	Gene	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of PSK on interleukin-2 production by peripheral lymphocytes of patients with advanced ovarian_carcinoma during chemotherapy .
7572178	0	interleukin-2	62,75	Phytolacca_acinosa_polysaccharides_I	11,47	interleukin-2	Phytolacca acinosa polysaccharides I	16183(Tax:10090)	11747(Tax:10090)	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|Effects Effects|nmod|END_ENTITY	Effects of Phytolacca_acinosa_polysaccharides_I combined with interleukin-2 on the cytotoxicity of murine splenocytes against tumor cells .
2789118	0	interleukin-2	54,67	Placental_protein_14	0,20	interleukin-2	Placental protein 14	3558	5047	Gene	Gene	synthesis|nmod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Placental_protein_14 -LRB- PP14 -RRB- inhibits the synthesis of interleukin-2 and the release of soluble interleukin-2 receptors from phytohaemagglutinin-stimulated lymphocytes .
2110979	0	interleukin-2	46,59	Pregnancy_zone_protein	0,22	interleukin-2	Pregnancy zone protein	3558	5858	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Pregnancy_zone_protein inhibits production of interleukin-2 but does not affect interleukin-2 receptor expression on T cell activation .
11340297	0	interleukin-2	40,53	SHP-2	154,159	interleukin-2	SHP-2	3558	5781	Gene	Gene	tyrosine|nmod|START_ENTITY cells|amod|tyrosine phosphorylated|nmod|cells phosphorylated|nmod|END_ENTITY	Gab2 is phosphorylated on tyrosine upon interleukin-2 / interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a .
15170389	0	interleukin-2	130,143	SHP-2	40,45	interleukin-2	SHP-2	3558	5781	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2 .
10373548	0	interleukin-2	49,62	STAT5	78,83	interleukin-2	STAT5	3558	6776	Gene	Gene	phosphorylated|nmod|START_ENTITY phosphorylated|nsubj|proliferation proliferation|nummod|END_ENTITY	SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation .
12425996	0	interleukin-2	47,60	STAT5	27,32	interleukin-2	STAT5	3558	6776	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils .
23167249	0	interleukin-2	128,141	STAT5	142,147	interleukin-2	STAT5	16183(Tax:10090)	20850(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Interleukin-2 / anti-interleukin-2 monoclonal antibody immune complex suppresses collagen-induced_arthritis in mice by fortifying interleukin-2 / STAT5 signalling pathways .
25509109	0	interleukin-2	59,72	STAT5	5,10	interleukin-2	STAT5	3558	6776	Gene	Gene	receptor|compound|START_ENTITY alpha-subunit|nmod|receptor expression|nmod|alpha-subunit signaling|nmod|expression END_ENTITY|acl|signaling	-LSB- The STAT5 signaling in the expression of alpha-subunit of interleukin-2 receptor in human_blood_lymphocytes -RSB- .
12231477	0	interleukin-2	69,82	Stat5	163,168	interleukin-2	Stat5	3558	6776	Gene	Gene	expression|nmod|START_ENTITY Induction|nmod|expression Induction|dep|role role|nmod|region region|nmod|sites sites|amod|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
7512581	0	interleukin-2	23,36	Substance_P	0,11	interleukin-2	Substance P	3558	6863	Gene	Gene	mRNA|compound|START_ENTITY stabilizes|dobj|mRNA stabilizes|nsubj|END_ENTITY	Substance_P stabilizes interleukin-2 mRNA in activated Jurkat cells .
3091711	0	interleukin-2	56,69	T-cell_replacing_factor	0,23	interleukin-2	T-cell replacing factor	3558	3567	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	T-cell_replacing_factor activity of recombinant-derived interleukin-2 requires gamma-interferon .
23057733	0	interleukin-2	27,40	TCR	12,15	interleukin-2	TCR	3558	6962	Gene	Gene	production|compound|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Upregulated TCR enhances interleukin-2 production in T-cells from patients with CML .
6332883	0	interleukin-2	32,45	THF	0,3	interleukin-2	THF	16183(Tax:10090)	21831(Tax:10090)	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	THF , a thymic hormone , promotes interleukin-2 production in intact and thymus-deprived mice .
21155952	0	interleukin-2	51,64	TRAF6	0,5	interleukin-2	TRAF6	16183(Tax:10090)	22034(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling .
12847689	0	interleukin-2	122,135	T_cell_receptor	94,109	interleukin-2	T cell receptor	3558	6962	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Reconstitution of deficient T_cell_receptor zeta chain restores T cell signaling and augments T_cell_receptor / CD3-induced interleukin-2 production in patients with systemic_lupus_erythematosus .
2581997	0	interleukin-2	83,96	Tac_antigen	61,72	interleukin-2	Tac antigen	3558	3559	Gene	Gene	receptor|compound|START_ENTITY expression|appos|receptor expression|amod|END_ENTITY	Partial restoration of impaired interleukin-2 production and Tac_antigen -LRB- putative interleukin-2 receptor -RRB- expression in patients with acquired_immune_deficiency_syndrome by isoprinosine treatment in vitro .
2787681	0	interleukin-2	23,36	Tac_antigen	47,58	interleukin-2	Tac antigen	3558	3559	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Elevated serum-soluble interleukin-2 receptor -LRB- Tac_antigen -RRB- levels in chronic_myelogenous_leukemia patients with blastic crisis .
2832410	0	interleukin-2	97,110	Tac_antigen	76,87	interleukin-2	Tac antigen	3558	3559	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Sequence requirements for ligand binding and cell surface expression of the Tac_antigen , a human interleukin-2 receptor .
3128947	0	interleukin-2	18,31	Tac_antigen	42,53	interleukin-2	Tac antigen	3558	3559	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|appos|CD25 CD25|compound|END_ENTITY	Expression of the interleukin-2 receptor -LRB- Tac_antigen / CD25 -RRB- in hematologic_neoplasms .
3929032	0	interleukin-2	33,46	Tac_antigen	57,68	interleukin-2	Tac antigen	3558	3559	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Biosynthetic processing of human interleukin-2 receptor -LRB- Tac_antigen -RRB- .
6100643	0	interleukin-2	23,36	Tac_antigen	47,58	interleukin-2	Tac antigen	3558	3559	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|appos|END_ENTITY	Abnormal expression of interleukin-2 receptor -LRB- Tac_antigen -RRB- in adult_T-cell_leukemia .
8423782	0	interleukin-2	88,101	Transforming_growth_factor_beta	0,31	interleukin-2	Transforming growth factor beta	3558	7040	Gene	Gene	gene|compound|START_ENTITY activity|nmod|gene inhibit|dobj|activity inhibit|nsubj|END_ENTITY	Transforming_growth_factor_beta and cyclosporin_A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site .
2086452	0	interleukin-2	14,27	YAC-1	31,36	interleukin-2	YAC-1	16183(Tax:10090)	11870(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Production of interleukin-2 by YAC-1 cells stimulated with interleukin-1 and its augmentation of the natural killer activity .
8071588	0	interleukin-2	109,122	Yac-1	56,61	interleukin-2	Yac-1	16183(Tax:10090)	11870(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY perforin|nmod|stimulation perforin|dobj|activity activity|compound|END_ENTITY	Macrophage precursor cells produce perforin and perform Yac-1 lytic activity in response to stimulation with interleukin-2 .
14741719	0	interleukin-2	94,107	ZHX1	69,73	interleukin-2	ZHX1	16183(Tax:10090)	22770(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	A mechanism of induction of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene expression by interleukin-2 .
11525798	0	interleukin-2	11,24	corticotropin-releasing_hormone	46,77	interleukin-2	corticotropin-releasing hormone	116562(Tax:10116)	81648(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of interleukin-2 on the expression of corticotropin-releasing_hormone in nerves and lymphoid cells in secondary lymphoid organs from the Fischer 344 rat .
14660677	0	interleukin-2	105,118	cyclin_D2	88,97	interleukin-2	cyclin D2	3558	894	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin_D2 by the interleukin-2 receptor .
10851461	0	interleukin-2	55,68	interferon-gamma	102,118	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	distribution|nmod|START_ENTITY affects|nsubj|distribution affects|dobj|release release|nmod|END_ENTITY	Dose distribution of low-dose subcutaneous recombinant interleukin-2 affects the secondary release of interferon-gamma in vivo .
15271977	0	interleukin-2	114,127	interferon-gamma	23,39	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	remodeling|nmod|START_ENTITY site|nmod|remodeling site|nsubj|region region|nmod|gene gene|amod|END_ENTITY	A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2 .
15493262	0	interleukin-2	59,72	interferon-gamma	8,24	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
15806975	0	interleukin-2	121,134	interferon-gamma	50,66	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	START_ENTITY|nsubj|efficacy efficacy|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
1639351	0	interleukin-2	18,31	interferon-gamma	154,170	interleukin-2	interferon-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	Administration|nmod|START_ENTITY induces|nsubj|Administration induces|nmod|production production|amod|END_ENTITY	Administration of interleukin-2 induces major histocompatibility complex class II expression on the biliary epithelial cells , possibly through endogenous interferon-gamma production .
17479215	0	interleukin-2	136,149	interferon-gamma	94,110	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	production|dep|START_ENTITY production|nmod|END_ENTITY	Modified penicillin acylase signal peptide allows the periplasmic production of soluble human interferon-gamma but not of soluble human interleukin-2 by the Tat pathway in Escherichia_coli .
1898716	0	interleukin-2	74,87	interferon-gamma	41,57	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|amod|END_ENTITY	Lymphokine-activated killer -LRB- LAK -RRB- cells : interferon-gamma synergizes with interleukin-2 to induce LAK_cytotoxicity in homogeneous leukemic preparations .
1902247	0	interleukin-2	94,107	interferon-gamma	65,81	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Immune cell activation in melioidosis : increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein .
1917162	0	interleukin-2	11,24	interferon-gamma	64,80	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	causes|nsubj|START_ENTITY causes|dobj|effect effect|nmod|induction induction|amod|END_ENTITY	Peri-tumor interleukin-2 causes systemic therapeutic effect via interferon-gamma induction .
19886902	0	interleukin-2	13,26	interferon-gamma	42,58	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	START_ENTITY|nmod|addition addition|nmod|END_ENTITY	Detection of interleukin-2 in addition to interferon-gamma discriminates active tuberculosis patients , latently infected individuals , and controls .
2113571	0	interleukin-2	31,44	interferon-gamma	71,87	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	trial|nmod|START_ENTITY combined|nsubj|trial combined|nmod|END_ENTITY	A phase I trial of recombinant interleukin-2 combined with recombinant interferon-gamma in patients with cancer .
2126575	0	interleukin-2	24,37	interferon-gamma	117,133	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	lymphokine|appos|START_ENTITY Decrease|nmod|lymphokine Decrease|dep|activity activity|nmod|END_ENTITY	Decrease of lymphokine -LRB- interleukin-2 -RRB- - activated killer activity in peripheral blood after administration of natural interferon-gamma .
3119733	0	interleukin-2	15,28	interferon-gamma	53,69	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	way|nsubj|START_ENTITY way|acl|deliver deliver|dobj|END_ENTITY	Is recombinant interleukin-2 the best way to deliver interferon-gamma in human disease ?
7496156	0	interleukin-2	18,31	interferon-gamma	32,48	interleukin-2	interferon-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	Immunization|nmod|START_ENTITY Immunization|parataxis|prolongs prolongs|nsubj|fibroblasts fibroblasts|amod|END_ENTITY	Immunization with interleukin-2 / interferon-gamma double cytokine-secreting allogeneic fibroblasts prolongs the survival of mice with melanoma .
7774618	0	interleukin-2	26,39	interferon-gamma	118,134	interleukin-2	interferon-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY made|nmod|production cells|acl|made primed|nsubjpass|cells primed|nmod|secretion secretion|amod|END_ENTITY	T cells made deficient in interleukin-2 production by exposure to staphylococcal enterotoxin B in vivo are primed for interferon-gamma and interleukin-10 secretion .
7842289	0	interleukin-2	141,154	interferon-gamma	121,137	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	analogs|compound|START_ENTITY END_ENTITY|nmod|analogs	Induction of lymphokine-activated killing with reduced secretion of interleukin-1 beta , tumor necrosis factor-alpha , and interferon-gamma by interleukin-2 analogs .
9101417	0	interleukin-2	12,25	interferon-gamma	58,74	interleukin-2	interferon-gamma	3558	3458	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Recombinant interleukin-2 in combination with recombinant interferon-gamma in patients with advanced malignancy : a phase 1 study .
10190313	0	interleukin-2	37,50	interferon_alpha2b	51,69	interleukin-2	interferon alpha2b	3558	3440	Gene	Gene	expression|nmod|START_ENTITY expression|dep|gene gene|amod|END_ENTITY	The targeted expression of the human interleukin-2 / interferon_alpha2b fused gene in alpha-fetoprotein-expressing hepatocellular_carcinoma cells .
8288885	0	interleukin-2	109,122	interleukin-1	74,87	interleukin-2	interleukin-1	3558	3552	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	A new human cell line for the molecular dissection of the requirement for interleukin-1 in the production of interleukin-2 by immature T cells .
26629148	0	interleukin-2	75,88	interleukin-10	89,103	interleukin-2	interleukin-10	116562(Tax:10116)	25325(Tax:10116)	Gene	Gene	Bax|compound|START_ENTITY Bax|dep|END_ENTITY	Berberine alleviates preeclampsia possibly by regulating the expression of interleukin-2 / interleukin-10 and Bcl-2 / Bax .
10447730	0	interleukin-2	166,179	interleukin-15	131,145	interleukin-2	interleukin-15	3558	3600	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Activation , survival and apoptosis of CD45RO + and CD45RO - T cells of human_immunodeficiency_virus-infected individuals : effects of interleukin-15 and comparison with interleukin-2 .
11340297	0	interleukin-2	40,53	interleukin-15	54,68	interleukin-2	interleukin-15	3558	3600	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|dep|T T|dep|stimulation stimulation|amod|END_ENTITY	Gab2 is phosphorylated on tyrosine upon interleukin-2 / interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a .
12969549	0	interleukin-2	104,117	interleukin-15	7,21	interleukin-2	interleukin-15	3558	3600	Gene	Gene	comparison|nmod|START_ENTITY Use|dep|comparison Use|nmod|cells cells|amod|END_ENTITY	Use of interleukin-15 for preparation of adherent NK cells from human peripheral blood : comparison with interleukin-2 .
7553894	0	interleukin-2	118,131	interleukin-15	58,72	interleukin-2	interleukin-15	16183(Tax:10090)	16168(Tax:10090)	Gene	Gene	comparison|nmod|START_ENTITY Studies|dep|comparison Studies|acl|evaluating evaluating|dobj|activity activity|nmod|END_ENTITY	Studies evaluating the antitumor activity and toxicity of interleukin-15 , a new T_cell_growth_factor : comparison with interleukin-2 .
10233698	0	interleukin-2	39,52	interleukin-16	21,35	interleukin-2	interleukin-16	3558	3603	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Inhibitory effect of interleukin-16 on interleukin-2 production by CD4 + T cells .
11858100	0	interleukin-2	39,52	interleukin-2	81,94	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- Levels of anti-inflammatory cytokines interleukin-2 , interleukin-8 , and soluble interleukin-2 receptor in blood of patients with various forms of ischemic_heart_disease -RSB- .
11858100	0	interleukin-2	81,94	interleukin-2	39,52	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- Levels of anti-inflammatory cytokines interleukin-2 , interleukin-8 , and soluble interleukin-2 receptor in blood of patients with various forms of ischemic_heart_disease -RSB- .
1363382	0	interleukin-2	32,45	interleukin-2	6,19	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Serum interleukin-2 and soluble interleukin-2 receptor in renal transplant recipients .
1363382	0	interleukin-2	6,19	interleukin-2	32,45	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Serum interleukin-2 and soluble interleukin-2 receptor in renal transplant recipients .
14680292	0	interleukin-2	120,133	interleukin-2	43,56	interleukin-2	interleukin-2	3558	3558	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Efficacy and safety of inhaled recombinant interleukin-2 in high-risk renal_cell_cancer patients compared with systemic interleukin-2 : an outcome study .
14680292	0	interleukin-2	43,56	interleukin-2	120,133	interleukin-2	interleukin-2	3558	3558	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Efficacy and safety of inhaled recombinant interleukin-2 in high-risk renal_cell_cancer patients compared with systemic interleukin-2 : an outcome study .
15562014	0	interleukin-2	76,89	interleukin-2	90,103	interleukin-2	interleukin-2	3558	3558	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2 / interleukin-2 receptor system .
15562014	0	interleukin-2	90,103	interleukin-2	76,89	interleukin-2	interleukin-2	3558	3558	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2 / interleukin-2 receptor system .
15622762	0	interleukin-2	41,54	interleukin-2	67,80	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe_aplastic_anemia patients -RSB- .
15622762	0	interleukin-2	67,80	interleukin-2	41,54	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe_aplastic_anemia patients -RSB- .
1612787	0	interleukin-2	29,42	interleukin-2	58,71	interleukin-2	interleukin-2	100379540(Tax:10141)	100379540(Tax:10141)	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	Polyethylene-glycol-modified interleukin-2 is superior to interleukin-2 in locoregional immunotherapy of established guinea-pig tumors .
1612787	0	interleukin-2	58,71	interleukin-2	29,42	interleukin-2	interleukin-2	100379540(Tax:10141)	100379540(Tax:10141)	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	Polyethylene-glycol-modified interleukin-2 is superior to interleukin-2 in locoregional immunotherapy of established guinea-pig tumors .
1641157	0	interleukin-2	31,44	interleukin-2	57,70	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Prospective serial analysis of interleukin-2 and soluble interleukin-2 receptor in relapsing-remitting multiple_sclerosis .
1641157	0	interleukin-2	57,70	interleukin-2	31,44	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Prospective serial analysis of interleukin-2 and soluble interleukin-2 receptor in relapsing-remitting multiple_sclerosis .
16690518	0	interleukin-2	61,74	interleukin-2	84,97	interleukin-2	interleukin-2	3558	3558	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Aggressive_non-Hodgkin 's _ lymphoma : concomitant evaluation of interleukin-2 , soluble interleukin-2 receptor , interleukin-4 , interleukin-6 , interleukin-10 and correlation with outcome .
16690518	0	interleukin-2	84,97	interleukin-2	61,74	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Aggressive_non-Hodgkin 's _ lymphoma : concomitant evaluation of interleukin-2 , soluble interleukin-2 receptor , interleukin-4 , interleukin-6 , interleukin-10 and correlation with outcome .
18782532	0	interleukin-2	46,59	interleukin-2	72,85	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver_cancer after transarterial chemoembolization therapy -RSB- .
18782532	0	interleukin-2	72,85	interleukin-2	46,59	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	-LSB- Effects of Jinlong Capsule on expressions of interleukin-2 and soluble interleukin-2 receptor in patients with primary liver_cancer after transarterial chemoembolization therapy -RSB- .
2002090	0	interleukin-2	20,33	interleukin-2	46,59	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	The relationship of interleukin-2 and soluble interleukin-2 receptors to intrathecal immunoglobulin synthesis in patients with multiple_sclerosis .
2002090	0	interleukin-2	46,59	interleukin-2	20,33	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	The relationship of interleukin-2 and soluble interleukin-2 receptors to intrathecal immunoglobulin synthesis in patients with multiple_sclerosis .
2061780	0	interleukin-2	26,39	interleukin-2	52,65	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Increased serum levels of interleukin-2 and soluble interleukin-2 receptor in celiac disease .
2061780	0	interleukin-2	52,65	interleukin-2	26,39	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Increased serum levels of interleukin-2 and soluble interleukin-2 receptor in celiac disease .
24684505	0	interleukin-2	68,81	interleukin-2	82,95	interleukin-2	interleukin-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	complexes|amod|START_ENTITY complexes|compound|END_ENTITY	Long-term tolerance to factor_VIII is achieved by administration of interleukin-2 / interleukin-2 monoclonal antibody complexes and low dosages of factor_VIII .
24684505	0	interleukin-2	82,95	interleukin-2	68,81	interleukin-2	interleukin-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	complexes|compound|START_ENTITY complexes|amod|END_ENTITY	Long-term tolerance to factor_VIII is achieved by administration of interleukin-2 / interleukin-2 monoclonal antibody complexes and low dosages of factor_VIII .
3876277	0	interleukin-2	22,35	interleukin-2	94,107	interleukin-2	interleukin-2	3558	3558	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of porcine interleukin-2 and its biological and antigenic relationships with human interleukin-2 .
3876277	0	interleukin-2	94,107	interleukin-2	22,35	interleukin-2	interleukin-2	3558	3558	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of porcine interleukin-2 and its biological and antigenic relationships with human interleukin-2 .
8288676	0	interleukin-2	60,73	interleukin-2	8,21	interleukin-2	interleukin-2	3558	3558	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Inhaled interleukin-2 in combination with low-dose systemic interleukin-2 and interferon alpha in patients with pulmonary metastatic renal-cell_carcinoma : effectiveness and toxicity of mainly local treatment .
8288676	0	interleukin-2	8,21	interleukin-2	60,73	interleukin-2	interleukin-2	3558	3558	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Inhaled interleukin-2 in combination with low-dose systemic interleukin-2 and interferon alpha in patients with pulmonary metastatic renal-cell_carcinoma : effectiveness and toxicity of mainly local treatment .
8388428	0	interleukin-2	32,45	interleukin-2	65,78	interleukin-2	interleukin-2	3558	3558	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Chronic effects of subcutaneous interleukin-2 therapy on soluble interleukin-2 receptors in advanced small_cell_lung_cancer .
8388428	0	interleukin-2	65,78	interleukin-2	32,45	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Chronic effects of subcutaneous interleukin-2 therapy on soluble interleukin-2 receptors in advanced small_cell_lung_cancer .
8437006	0	interleukin-2	15,28	interleukin-2	41,54	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Correlation of interleukin-2 and soluble interleukin-2 receptor with clinical activity of multiple_sclerosis .
8437006	0	interleukin-2	41,54	interleukin-2	15,28	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Correlation of interleukin-2 and soluble interleukin-2 receptor with clinical activity of multiple_sclerosis .
8612350	0	interleukin-2	18,31	interleukin-2	47,60	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Downregulation of interleukin-2 and apha-chain interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes .
8612350	0	interleukin-2	47,60	interleukin-2	18,31	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Downregulation of interleukin-2 and apha-chain interleukin-2 receptor biosynthesis by cisplatin in human peripheral lymphocytes .
8796806	0	interleukin-2	32,45	interleukin-2	6,19	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Serum interleukin-2 and soluble interleukin-2 receptor in gestational_trophoblastic_diseases .
8796806	0	interleukin-2	6,19	interleukin-2	32,45	interleukin-2	interleukin-2	3558	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Serum interleukin-2 and soluble interleukin-2 receptor in gestational_trophoblastic_diseases .
1472581	0	interleukin-2	163,176	interleukin-2_receptor	63,85	interleukin-2	interleukin-2 receptor	3558	3559	Gene	Gene	stimulation|nmod|START_ENTITY express|nmod|stimulation express|dobj|END_ENTITY	In vivo activated cord blood lymphocytes express high affinity interleukin-2_receptor : evaluation of their responsiveness to in vitro stimulation with recombinant interleukin-2 .
1535451	0	interleukin-2	46,59	interleukin-2_receptor	96,118	interleukin-2	interleukin-2 receptor	3558	3559	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Inhibition of interleukin-1 _ -LRB- alpha_and_beta -RRB- , interleukin-2 secretion and surface expression of interleukin-2_receptor -LRB- IL-2R -RRB- by a novel cytokine interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- .
3109849	0	interleukin-2	138,151	interleukin-2_receptor	15,37	interleukin-2	interleukin-2 receptor	3558	3559	Gene	Gene	testosterone-enhanced|advcl|START_ENTITY production|amod|testosterone-enhanced increased|nmod|production END_ENTITY|dep|increased	Elevated serum interleukin-2_receptor ; increased in vitro immunoglobulin synthesis and lack of response to testosterone-enhanced in vitro interleukin-2 production in ankylosing_spondylitis .
7696095	0	interleukin-2	68,81	interleukin-2_receptor	16,38	interleukin-2	interleukin-2 receptor	3558	3559	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	T-cell subsets , interleukin-2_receptor expression and production of interleukin-2 in minimal change_nephrotic_syndrome .
12231477	0	interleukin-2	69,82	interleukin-2_receptor_alpha	13,41	interleukin-2	interleukin-2 receptor alpha	3558	3559	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
1511423	0	interleukin-2	139,152	interleukin-2_receptor_alpha	27,55	interleukin-2	interleukin-2 receptor alpha	3558	3559	Gene	Gene	treated|nmod|START_ENTITY treated|nsubj|expression expression|nmod|chain chain|amod|END_ENTITY	Variable expression of the interleukin-2_receptor_alpha chain and MYC genes in lymphocytes from renal_cell_carcinoma patients treated with interleukin-2 .
1462123	0	interleukin-2	42,55	interleukin-3	57,70	interleukin-2	interleukin-3	3558	3562	Gene	Gene	transcription|nmod|START_ENTITY Spontaneous|nmod|transcription Spontaneous|appos|interferon-gamma interferon-gamma|amod|END_ENTITY	Spontaneous in vivo gene transcription of interleukin-2 , interleukin-3 , interleukin-4 , interleukin-6 , _ interferon-gamma , _ interleukin-2_receptor -LRB- CD25 -RRB- and proto-oncogene_c-myc by rheumatoid synovial T lymphocytes .
3088729	0	interleukin-2	32,45	interleukin-3	81,94	interleukin-2	interleukin-3	3558	3562	Gene	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor Regulation|nmod|END_ENTITY	Regulation of expression of the interleukin-2 receptor on hematopoietic cells by interleukin-3 .
3928979	0	interleukin-2	61,74	interleukin-3	5,18	interleukin-2	interleukin-3	16183(Tax:10090)	16187(Tax:10090)	Gene	Gene	respond|nmod|START_ENTITY respond|nsubj|lines lines|amod|dependent dependent|amod|END_ENTITY	Some interleukin-3 dependent mast-cell lines also respond to interleukin-2 .
8443757	0	interleukin-2	81,94	interleukin-3	31,44	interleukin-2	interleukin-3	3558	3562	Gene	Gene	induced|nmod|START_ENTITY activation|acl|induced END_ENTITY|nmod|activation	In vitro modulatory effects of interleukin-3 on macrophage activation induced by interleukin-2 .
9569233	0	interleukin-2	76,89	interleukin-3	91,104	interleukin-2	interleukin-3	3558	3562	Gene	Gene	colony-stimulating_factor|compound|START_ENTITY colony-stimulating_factor|dep|END_ENTITY	Interleukin-5 mRNA stability in human T cells is regulated differently than interleukin-2 , interleukin-3 , interleukin-4 , _ granulocyte/macrophage _ colony-stimulating_factor , _ and_interferon-gamma .
8766562	0	interleukin-2	75,88	interleukin-4	28,41	interleukin-2	interleukin-4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	not|nmod|START_ENTITY expression|dep|not expression|nmod|END_ENTITY	Early message expression of interleukin-4 and interferon-gamma , but not of interleukin-2 and interleukin-10 , reflects later polarization of primary CD4 + T cell cultures .
12070682	0	interleukin-2	35,48	interleukin-6	12,25	interleukin-2	interleukin-6	3558	3569	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Circulating interleukin-6 , soluble interleukin-2 receptors , tumor_necrosis_factor_alpha , and interleukin-10 levels in juvenile_chronic_arthritis : correlations with soft tissue vascularity assessed by power Doppler sonography .
12223256	0	interleukin-2	9,22	interleukin-6	24,37	interleukin-2	interleukin-6	3558	3569	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Elevated interleukin-2 , interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia : association with psychopathology .
15531955	0	interleukin-2	6,19	interleukin-6	21,34	interleukin-2	interleukin-6	3558	3569	Gene	Gene	necrosis|nsubj|START_ENTITY necrosis|dep|END_ENTITY	Serum interleukin-2 , interleukin-6 , tumour necrosis factor-alpha and nitric_oxide levels in patients with Behcet 's _ disease .
16690518	0	interleukin-2	84,97	interleukin-6	123,136	interleukin-2	interleukin-6	3558	3569	Gene	Gene	receptor|compound|START_ENTITY interleukin-2|appos|receptor interleukin-2|amod|END_ENTITY	Aggressive_non-Hodgkin 's _ lymphoma : concomitant evaluation of interleukin-2 , soluble interleukin-2 receptor , interleukin-4 , interleukin-6 , interleukin-10 and correlation with outcome .
1704262	0	interleukin-2	38,51	interleukin-6	104,117	interleukin-2	interleukin-6	3558	3569	Gene	Gene	immunotherapy|nmod|START_ENTITY immunotherapy|dep|kinetics kinetics|acl|circulating circulating|nmod|level level|amod|END_ENTITY	Adoptive immunotherapy with high-dose interleukin-2 : kinetics of circulating progenitors correlate with interleukin-6 , granulocyte colony-stimulating factor level .
1827050	0	interleukin-2	71,84	interleukin-6	12,25	interleukin-2	interleukin-6	3558	3569	Gene	Gene	RNA|compound|START_ENTITY detection|nmod|RNA role|dep|detection role|nmod|END_ENTITY	The role of interleukin-6 in mitogenic T-cell activation : detection of interleukin-2 heteronuclear RNA by polymerase chain reaction .
1912580	0	interleukin-2	191,204	interleukin-6	130,143	interleukin-2	interleukin-6	3558	3569	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	In vivo production of interleukin-5 , granulocyte-macrophage colony-stimulating factor , macrophages colony-stimulating factor , and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients .
26555352	0	interleukin-2	32,45	interleukin-6	15,28	interleukin-2	interleukin-6	3558	3569	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	Baseline serum interleukin-6 to interleukin-2 ratio is associated with the response to seasonal trivalent influenza vaccine in solid organ transplant recipients .
7719378	0	interleukin-2	109,122	interleukin-6	36,49	interleukin-2	interleukin-6	3558	3569	Gene	Gene	subcutaneous|dobj|START_ENTITY subcutaneous|nsubj|dependency dependency|nmod|secretion secretion|amod|END_ENTITY	In vivo time and dose dependency of interleukin-6 secretion in response to low-dose subcutaneous recombinant interleukin-2 .
8697075	0	interleukin-2	21,34	interleukin-6	86,99	interleukin-2	interleukin-6	16183(Tax:10090)	16193(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY gene-transfected|nsubj|effect gene-transfected|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Antitumor effect of interleukin-2 gene-transfected tumor vaccine in combination with interleukin-6 gene-transfected tumor vaccine -RSB- .
9135506	0	interleukin-2	200,213	interleukin-6	63,76	interleukin-2	interleukin-6	3558	3569	Gene	Gene	cancer|nmod|START_ENTITY immunotherapy|nmod|cancer advanced|nmod|immunotherapy advanced|nsubj|effects effects|nmod|administration administration|nmod|levels levels|nmod|END_ENTITY	Acute effects of pamidronate administration on serum levels of interleukin-6 in advanced solid tumour patients with bone metastases and their possible implications in the immunotherapy of cancer with interleukin-2 .
9474133	0	interleukin-2	84,97	interleukin-6	6,19	interleukin-2	interleukin-6	3558	3569	Gene	Gene	treatment|nmod|START_ENTITY metastatic_renal_cell_carcinoma|nmod|treatment levels|nmod|metastatic_renal_cell_carcinoma levels|amod|END_ENTITY	Serum interleukin-6 levels in metastatic_renal_cell_carcinoma before treatment with interleukin-2 correlates with paraneoplastic_syndromes but not patient survival .
11858100	0	interleukin-2	39,52	interleukin-8	54,67	interleukin-2	interleukin-8	3558	3576	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	-LSB- Levels of anti-inflammatory cytokines interleukin-2 , interleukin-8 , and soluble interleukin-2 receptor in blood of patients with various forms of ischemic_heart_disease -RSB- .
11858100	0	interleukin-2	81,94	interleukin-8	54,67	interleukin-2	interleukin-8	3558	3576	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	-LSB- Levels of anti-inflammatory cytokines interleukin-2 , interleukin-8 , and soluble interleukin-2 receptor in blood of patients with various forms of ischemic_heart_disease -RSB- .
15452601	0	interleukin-2	69,82	interleukin-8	40,53	interleukin-2	interleukin-8	3558	3576	Gene	Gene	production|compound|START_ENTITY correction|nmod|production correction|amod|END_ENTITY	Fibrinogen and its oxidized form induce interleukin-8 -LSB- correction of interleukin-2 -RSB- production in cultured endothelial cells of human vessels .
7696165	0	interleukin-2	69,82	interleukin-8	15,28	interleukin-2	interleukin-8	3558	3576	Gene	Gene	release|nmod|START_ENTITY release|nmod|treatment treatment|amod|END_ENTITY	The release of interleukin-8 during intravenous bolus treatment with interleukin-2 .
1720417	0	interleukin-2	93,106	membrane-bound	66,80	interleukin-2	membrane-bound	3558	19	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	The immunosuppressive agent FK506 inhibits in vitro expression of membrane-bound and soluble interleukin-2 receptors on resting but not on activated human lymphocytes .
15569157	0	interleukin-2	61,74	multidrug_resistance-1	30,52	interleukin-2	multidrug resistance-1	3558	5243	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of multidrug_resistance-1 gene by interleukin-2 in lymphocytes .
18353062	0	interleukin-2	10,23	osteopontin	59,70	interleukin-2	osteopontin	3558	6696	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin-2 and tumor_necrosis_factor-alpha on osteopontin : molecular function and biological process .
11313336	0	interleukin-2	25,38	p300	13,17	interleukin-2	p300	3558	2033	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Targeting of p300 to the interleukin-2 promoter via CREB-Rel cross-talk during mitogen and oncogenic molecular signaling in activated T-cells .
1487324	0	interleukin-2	29,42	p55	25,28	interleukin-2	p55	3558	3559	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Pokeweed mitogen induces p55 interleukin-2 receptor expression on human monocytes and its effect on interleukin-2 activated monocyte cytotoxicity .
1581584	0	interleukin-2	67,80	p55	27,30	interleukin-2	p55	3558	3559	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|amod|END_ENTITY	Phorbol_esters up-regulate p55 and down-regulate p75 expression of interleukin-2 receptors in human T cells .
1691591	0	interleukin-2	24,37	p55	14,17	interleukin-2	p55	3558	3559	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p55 -LRB- Tac -RRB- interleukin-2 receptor -LRB- IL-2R -RRB- , but not p75 IL-2R , in cultured H-RS cells and H-RS cells in tissues .
2243505	0	interleukin-2	53,66	p55	39,42	interleukin-2	p55	3558	3559	Gene	Gene	receptor|compound|START_ENTITY chain|nmod|receptor chain|appos|END_ENTITY	Intracytoplasmic detection of the Tac -LRB- p55 -RRB- chain of interleukin-2 receptor in pre-B leukemic cells associated with a constitutive expression of Tac mRNA .
2312149	0	interleukin-2	85,98	p55	45,48	interleukin-2	p55	3558	3559	Gene	Gene	receptor|compound|START_ENTITY chains|nmod|receptor chains|amod|END_ENTITY	Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin_A .
2588963	0	interleukin-2	62,75	p55	86,89	interleukin-2	p55	3558	3559	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	1_alpha , _ 25-dihydroxyvitamin_D3 enhances the up-regulation of interleukin-2 receptor -LRB- p55 -RRB- by interleukin-2 .
2588963	0	interleukin-2	94,107	p55	86,89	interleukin-2	p55	3558	3559	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|up-regulation up-regulation|nmod|receptor receptor|appos|END_ENTITY	1_alpha , _ 25-dihydroxyvitamin_D3 enhances the up-regulation of interleukin-2 receptor -LRB- p55 -RRB- by interleukin-2 .
2787321	0	interleukin-2	154,167	p55	119,122	interleukin-2	p55	3558	3559	Gene	Gene	receptor|compound|START_ENTITY component|nmod|receptor component|amod|END_ENTITY	Crystallization and preliminary X-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high affinity interleukin-2 receptor .
7522954	0	interleukin-2	135,148	p55	26,29	interleukin-2	p55	3558	3559	Gene	Gene	administration|nmod|START_ENTITY expression|nmod|administration expression|nmod|interleukin-2_receptors interleukin-2_receptors|amod|END_ENTITY	Independent expression of p55 and p75 interleukin-2_receptors -LRB- IL-2R -RRB- during intravenous or subcutaneous administration of recombinant interleukin-2 -LRB- rIL-2 -RRB- by T-lymphocytes and natural killer cells .
8458377	0	interleukin-2	27,40	p55	68,71	interleukin-2	p55	3558	3559	Gene	Gene	Asp20|nmod|START_ENTITY Mutation|nmod|Asp20 reveals|nsubj|Mutation reveals|dobj|role role|nmod|chain chain|amod|alpha alpha|dep|END_ENTITY	Mutation of Asp20 of human interleukin-2 reveals a dual role of the p55 alpha chain of the interleukin-2 receptor .
8458377	0	interleukin-2	91,104	p55	68,71	interleukin-2	p55	3558	3559	Gene	Gene	receptor|compound|START_ENTITY chain|nmod|receptor chain|amod|alpha alpha|dep|END_ENTITY	Mutation of Asp20 of human interleukin-2 reveals a dual role of the p55 alpha chain of the interleukin-2 receptor .
8564714	0	interleukin-2	61,74	p55	84,87	interleukin-2	p55	280822(Tax:9913)	281861(Tax:9913)	Gene	Gene	chain|compound|START_ENTITY chain|amod|END_ENTITY	Interleukin-10 downregulates proliferation and expression of interleukin-2 receptor p55 chain and interferon-gamma , but not interleukin-2 or interleukin-4 , by parasite-specific helper T cell clones obtained from cattle chronically infected with Babesia_bovis or Fasciola_hepatica .
8473282	0	interleukin-2	60,73	p56lck	86,92	interleukin-2	p56lck	3558	3932	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Calcium-dependent cyclosporin_A-sensitive activation of the interleukin-2 promoter by p56lck .
2295000	0	interleukin-2	47,60	p70	28,31	interleukin-2	p70	3558	84959	Gene	Gene	receptor|compound|START_ENTITY subunit|nmod|receptor subunit|amod|END_ENTITY	Selective expression of the p70 subunit of the interleukin-2 receptor on lymphocytes from patients with infectious_mononucleosis .
1430108	0	interleukin-2	31,44	p75	27,30	interleukin-2	p75	3558	3560	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Expression of a functional p75 interleukin-2 receptor on lung lymphocytes from patients with human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- _ infection .
1581584	0	interleukin-2	67,80	p75	49,52	interleukin-2	p75	3558	3560	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|amod|END_ENTITY	Phorbol_esters up-regulate p55 and down-regulate p75 expression of interleukin-2 receptors in human T cells .
7509162	0	interleukin-2	145,158	p75	133,136	interleukin-2	p75	3558	3560	Gene	Gene	receptor|compound|START_ENTITY _|nmod|receptor _|appos|END_ENTITY	Inhibition of lymphokine-activated killer cells by human pulmonary macrophages : discordance between up-regulation of the beta_chain _ -LRB- p75 -RRB- of the interleukin-2 receptor on CD56 + cells and limited response to interleukin-2 .
18208763	0	interleukin-2	24,37	rIL-2	39,44	interleukin-2	rIL-2	3558	116562(Tax:10116)	Gene	Gene	Efficacy|nmod|START_ENTITY Efficacy|dep|END_ENTITY	Efficacy of recombinant interleukin-2 -LRB- rIL-2 -RRB- in patients with advanced_HIV-1_infection and blunted immune response to HAART .
2122928	0	interleukin-2	31,44	rIL-2	75,80	interleukin-2	rIL-2	3558	116562(Tax:10116)	Gene	Gene	trial|nmod|START_ENTITY trial|dep|activation activation|nmod|END_ENTITY	Phase I trial with recombinant interleukin-2 -LRB- rIL-2 -RRB- : immune activation by rIL-2 alone or following pretreatment with recombinant interferon-gamma .
2402104	0	interleukin-2	38,51	rIL-2	53,58	interleukin-2	rIL-2	3558	116562(Tax:10116)	Gene	Gene	cytotoxicity|nmod|START_ENTITY Study|nmod|cytotoxicity Study|dep|END_ENTITY	-LSB- Study of cytotoxicity of recombinant interleukin-2 -LRB- rIL-2 -RRB- expanded tumor infiltrating lymphocytes -LRB- TIL -RRB- in renal_cell_cancer -RSB- .
7820116	0	interleukin-2	54,67	rIL-2	159,164	interleukin-2	rIL-2	16183(Tax:10090)	116562(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY Enhancement|nmod|activity monoclonal|nsubj|Enhancement monoclonal|dobj|antibody antibody|nmod|END_ENTITY	Enhancement of the anti-tumor activity of recombinant interleukin-2 -LRB- rIL-2 -RRB- by immunocomplexing with an F -LRB- ab ' -RRB- 2 fragment of murine monoclonal antibody against rIL-2 .
7820116	0	interleukin-2	54,67	rIL-2	69,74	interleukin-2	rIL-2	16183(Tax:10090)	116562(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY Enhancement|nmod|activity Enhancement|dep|END_ENTITY	Enhancement of the anti-tumor activity of recombinant interleukin-2 -LRB- rIL-2 -RRB- by immunocomplexing with an F -LRB- ab ' -RRB- 2 fragment of murine monoclonal antibody against rIL-2 .
8280492	0	interleukin-2	30,43	rIL-2	84,89	interleukin-2	rIL-2	3558	116562(Tax:10116)	Gene	Gene	Reconstitution|nmod|START_ENTITY Reconstitution|dep|study study|nmod|muteins muteins|amod|END_ENTITY	Reconstitution of recombinant interleukin-2 -LRB- rIL-2 -RRB- : a comparative study of various rIL-2 muteins .
8292462	0	interleukin-2	50,63	rIL-2	127,132	interleukin-2	rIL-2	16183(Tax:10090)	116562(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY Enhancement|nmod|activity Enhancement|advcl|immunocomplexing immunocomplexing|nmod|antibody antibody|nmod|END_ENTITY	Enhancement of anti-tumor activity of recombinant interleukin-2 -LRB- rIL-2 -RRB- by immunocomplexing with a monoclonal antibody against rIL-2 .
9038610	0	interleukin-2	37,50	rIL-2	52,57	interleukin-2	rIL-2	3558	116562(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	The cognitive effects of recombinant interleukin-2 -LRB- rIL-2 -RRB- therapy : a controlled clinical trial using computerised assessments .
9414409	0	interleukin-2	50,63	rIL-2	122,127	interleukin-2	rIL-2	16183(Tax:10090)	116562(Tax:10116)	Gene	Gene	therapy|compound|START_ENTITY success|nmod|therapy dependent|nsubj|success dependent|nmod|time time|nmod|administration administration|amod|END_ENTITY	The success of locoregional , low-dose recombinant interleukin-2 therapy in tumor-bearing mice is dependent on the time of rIL-2 administration .
7903432	0	interleukin-2	17,30	somatostatin	49,61	interleukin-2	somatostatin	3558	6750	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	The influence of interleukin-2 on the release of somatostatin and growth hormone-releasing hormone by mediobasal_hypothalamus .
2164120	0	interleukin-2	23,36	tac_antigen	143,154	interleukin-2	tac antigen	3558	3559	Gene	Gene	START_ENTITY|amod|dependent dependent|nmod|phenotype phenotype|acl:relcl|express express|dobj|END_ENTITY	Characterization of an interleukin-2 dependent human leukemic cell line , PER-315 , with an immature T cell phenotype which does not express the tac_antigen .
2825998	0	interleukin-2	14,27	tac_antigen	46,57	interleukin-2	tac antigen	3558	3559	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of interleukin-2 and expression of tac_antigen in Hodgkin_disease .
8380285	0	interleukin-2	29,42	transforming_growth_factor_beta	79,110	interleukin-2	transforming growth factor beta	3558	7040	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Effect of anti-CD3 / anti-CD28 / interleukin-2 stimulation of mononuclear cells on transforming_growth_factor_beta inhibition of lymphokine-activated killer cell generation .
3265420	0	interleukin-2	104,117	tumor_necrosis_factor	25,46	interleukin-2	tumor necrosis factor	3558	7124	Gene	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	Induction of circulating tumor_necrosis_factor -LRB- TNF_alpha -RRB- as the mechanism for the febrile response to interleukin-2 -LRB- IL-2 -RRB- in cancer patients .
10569139	0	interleukin-2	184,197	tumor_necrosis_factor-alpha	24,51	interleukin-2	tumor necrosis factor-alpha	3558	7124	Gene	Gene	control|nmod|START_ENTITY control|nsubj|concentrations concentrations|nmod|END_ENTITY	Blood concentrations of tumor_necrosis_factor-alpha in malignant_lymphomas and their decrease as a predictor of disease control in response to low-dose subcutaneous immunotherapy with interleukin-2 .
15806975	0	interleukin-2	121,134	tumor_necrosis_factor-alpha	80,107	interleukin-2	tumor necrosis factor-alpha	3558	7124	Gene	Gene	START_ENTITY|nsubj|efficacy efficacy|appos|interferon-gamma interferon-gamma|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
19922107	0	interleukin-2	85,98	tumor_necrosis_factor-alpha	45,72	interleukin-2	tumor necrosis factor-alpha	3558	7124	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Clinical significance of measuring levels of tumor_necrosis_factor-alpha and soluble interleukin-2 receptor in nasopharyngeal_carcinoma .
2056069	0	interleukin-2	65,78	tumor_necrosis_factor-alpha	95,122	interleukin-2	tumor necrosis factor-alpha	3558	7124	Gene	Gene	levels|compound|START_ENTITY levels|dep|levels levels|amod|END_ENTITY	Serum cytokine levels in chronic_progressive_multiple_sclerosis : interleukin-2 levels parallel tumor_necrosis_factor-alpha levels .
1333789	0	interleukin-2	76,89	tumour_necrosis_factor	21,43	interleukin-2	tumour necrosis factor	3558	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|receptors receptors|compound|END_ENTITY	Induction of soluble tumour_necrosis_factor receptors during treatment with interleukin-2 .
14741719	0	interleukin-2	94,107	zinc-fingers_and_homeoboxes_1	38,67	interleukin-2	zinc-fingers and homeoboxes 1	16183(Tax:10090)	22770(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	A mechanism of induction of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene expression by interleukin-2 .
18281483	0	interleukin-21	64,78	CD4	82,85	interleukin-21	CD4	59067	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential effects of interleukin-2 and interleukin-15 versus interleukin-21 on CD4 + cutaneous_T-cell_lymphoma cells .
21047960	0	interleukin-21	15,29	CD4	31,34	interleukin-21	CD4	60505(Tax:10090)	12504(Tax:10090)	Gene	Gene	responses|amod|START_ENTITY responses|compound|END_ENTITY	HIV-1-specific interleukin-21 + CD4 + T cell responses contribute to durable viral control through the modulation of HIV-specific CD8 + T cell function .
24495300	0	interleukin-21	23,37	CD4	52,55	interleukin-21	CD4	59067	920	Gene	Gene	production|amod|START_ENTITY production|nmod|T T|compound|END_ENTITY	Oestrogen up-regulates interleukin-21 production by CD4 -LRB- + -RRB- T lymphocytes in patients with systemic_lupus_erythematosus .
19159826	0	interleukin-21	14,28	interleukin-21	30,44	interleukin-21	interleukin-21	365769(Tax:10116)	365769(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression of interleukin-21 , interleukin-21 receptor alpha and related type I cytokines by intravascular graft leukocytes during acute renal allograft rejection .
19159826	0	interleukin-21	30,44	interleukin-21	14,28	interleukin-21	interleukin-21	365769(Tax:10116)	365769(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression of interleukin-21 , interleukin-21 receptor alpha and related type I cytokines by intravascular graft leukocytes during acute renal allograft rejection .
17393408	0	interleukin-21	16,30	interleukin-21_receptor	31,54	interleukin-21	interleukin-21 receptor	60505(Tax:10090)	60504(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Blockade of the interleukin-21 / interleukin-21_receptor pathway ameliorates disease in animal models of rheumatoid_arthritis .
17393408	0	interleukin-21_receptor	31,54	interleukin-21	16,30	interleukin-21 receptor	interleukin-21	60504(Tax:10090)	60505(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Blockade of the interleukin-21 / interleukin-21_receptor pathway ameliorates disease in animal models of rheumatoid_arthritis .
17438334	0	interleukin-22	4,18	STAT3	19,24	interleukin-22	STAT3	50616	6774	Gene	Gene	START_ENTITY|parataxis|potentiates potentiates|nsubj|END_ENTITY	The interleukin-22 / STAT3 pathway potentiates expression of inducible_nitric-oxide_synthase in human colon_carcinoma cells .
22922995	0	interleukin-22	34,48	STAT3	0,5	interleukin-22	STAT3	50616	6774	Gene	Gene	signal|nmod|START_ENTITY signal|nsubj|END_ENTITY	STAT3 signal transduction through interleukin-22 in oral_squamous_cell_carcinoma .
23674871	0	interleukin-22	14,28	STAT3	29,34	interleukin-22	STAT3	50616	6774	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|signaling signaling|nsubj|END_ENTITY	Expression of interleukin-22 / STAT3 signaling pathway in ulcerative_colitis and related carcinogenesis .
24412612	0	interleukin-22	42,56	STAT3	85,90	interleukin-22	STAT3	50929(Tax:10090)	20848(Tax:10090)	Gene	Gene	protection|amod|START_ENTITY protection|compound|END_ENTITY	Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal_infection .
23973224	0	interleukin-22	107,121	aryl_hydrocarbon_receptor	46,71	interleukin-22	aryl hydrocarbon receptor	50616	196	Gene	Gene	reactivity|nmod|START_ENTITY reactivity|compound|END_ENTITY	Tryptophan catabolites from microbiota engage aryl_hydrocarbon_receptor and balance mucosal reactivity via interleukin-22 .
23777496	0	interleukin-23	62,76	THP-1	110,115	interleukin-23	THP-1	27178	2736	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Ciclosporin_A inhibits production of interleukin-12 / 23p40 and interleukin-23 by the human monocyte cell line , THP-1 .
22127978	0	interleukin-23	107,121	interferon_regulatory_factor_3	9,39	interleukin-23	interferon regulatory factor 3	27178	3661	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|END_ENTITY	Enhanced interferon_regulatory_factor_3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic_lupus_erythematosus .
23250909	0	interleukin-23_receptor	117,140	Interleukin_23	0,14	interleukin-23 receptor	Interleukin 23	149233	27178	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Interleukin_23 regulates proliferation of lung_cancer cells in a concentration-dependent way in association with the interleukin-23_receptor .
12671732	0	interleukin-23_receptor	41,64	beta1	66,71	interleukin-23 receptor	beta1	149233	3779	Gene	Gene	chain|amod|START_ENTITY chain|appos|END_ENTITY	Genetic variations in the interleukin-12 / interleukin-23_receptor -LRB- beta1 -RRB- chain , and implications for IL-12 and IL-23_receptor structure and function .
18046450	0	interleukin-24	101,115	MDA-7	95,100	interleukin-24	MDA-7	11009	11009	Gene	Gene	/|amod|START_ENTITY /|compound|END_ENTITY	Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7 / interleukin-24 for B-lymphoblastic_leukemia via induction of apoptosis .
26361419	0	interleukin-24	36,50	Notch1	0,6	interleukin-24	Notch1	11009	4851	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular_carcinoma cells .
20454646	0	interleukin-27	19,33	CD8	37,40	interleukin-27	CD8	246778	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	A pivotal role for interleukin-27 in CD8 + T cell functions and generation of cytotoxic T lymphocytes .
26900987	0	interleukin-27	75,89	Fli-1	21,26	interleukin-27	Fli-1	246778	2313	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Transcription factor Fli-1 positively regulates lipopolysaccharide-induced interleukin-27 production in macrophages .
22069308	0	interleukin-27	17,31	IL-27	33,38	interleukin-27	IL-27	246779(Tax:10090)	246779(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for interleukin-27 -LRB- IL-27 -RRB- as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription -LRB- STAT -RRB- protein signaling and induction of antibacterial and anti-inflammatory proteins .
2075380	0	interleukin-2_receptor	23,45	Interleukin-2	0,13	interleukin-2 receptor	Interleukin-2	3559	3558	Gene	Gene	factor|nsubj|START_ENTITY factor|advmod|END_ENTITY	Interleukin-2 , soluble interleukin-2_receptor and tumor necrosis factor in sera from patients with rheumatoid_arthritis .
9166099	0	interleukin-2_receptor	61,83	Interleukin-2	0,13	interleukin-2 receptor	Interleukin-2	3559	3558	Gene	Gene	malignancies|amod|START_ENTITY therapy|nmod|malignancies protein|dep|therapy protein|amod|END_ENTITY	Interleukin-2 fusion protein : an investigational therapy for interleukin-2_receptor expressing malignancies .
8805854	0	interleukin-2_receptor	14,36	THP-1	94,99	interleukin-2 receptor	THP-1	3559	2736	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of interleukin-2_receptor gamma_chain mRNA expression in human monocytic cell line THP-1 .
1472581	0	interleukin-2_receptor	63,85	interleukin-2	163,176	interleukin-2 receptor	interleukin-2	3559	3558	Gene	Gene	express|dobj|START_ENTITY express|nmod|stimulation stimulation|nmod|END_ENTITY	In vivo activated cord blood lymphocytes express high affinity interleukin-2_receptor : evaluation of their responsiveness to in vitro stimulation with recombinant interleukin-2 .
1535451	0	interleukin-2_receptor	96,118	interleukin-2	46,59	interleukin-2 receptor	interleukin-2	3559	3558	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of interleukin-1 _ -LRB- alpha_and_beta -RRB- , interleukin-2 secretion and surface expression of interleukin-2_receptor -LRB- IL-2R -RRB- by a novel cytokine interleukin-1_receptor_antagonist -LRB- IL-1ra -RRB- .
3109849	0	interleukin-2_receptor	15,37	interleukin-2	138,151	interleukin-2 receptor	interleukin-2	3559	3558	Gene	Gene	START_ENTITY|dep|increased increased|nmod|production production|amod|testosterone-enhanced testosterone-enhanced|advcl|END_ENTITY	Elevated serum interleukin-2_receptor ; increased in vitro immunoglobulin synthesis and lack of response to testosterone-enhanced in vitro interleukin-2 production in ankylosing_spondylitis .
7696095	0	interleukin-2_receptor	16,38	interleukin-2	68,81	interleukin-2 receptor	interleukin-2	3559	3558	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	T-cell subsets , interleukin-2_receptor expression and production of interleukin-2 in minimal change_nephrotic_syndrome .
1680935	0	interleukin-2_receptor	17,39	p55	41,44	interleukin-2 receptor	p55	3559	3559	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of the interleukin-2_receptor -LRB- p55 -RRB- by interferons .
2449607	0	interleukin-2_receptor	139,161	p55	114,117	interleukin-2 receptor	p55	16184(Tax:10090)	21937(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Characterization of three monoclonal antibodies specifically directed against the ligand binding site area of the p55 subunit of the mouse interleukin-2_receptor .
2146981	0	interleukin-2_receptor	67,89	p75	52,55	interleukin-2 receptor	p75	3559	3560	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Cell membrane expression and functional role of the p75 subunit of interleukin-2_receptor in lymphoproliferative_disease_of_granular_lymphocytes .
12231477	0	interleukin-2_receptor_alpha	13,41	IL-2Ralpha	43,53	interleukin-2 receptor alpha	IL-2Ralpha	3559	3559	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
17371467	0	interleukin-2_receptor_alpha	19,47	IL-2Ralpha	49,59	interleukin-2 receptor alpha	IL-2Ralpha	3559	3559	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Association of the interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- / CD25 gene region with Graves ' _ disease using a multilocus test and tag SNPs .
12231477	0	interleukin-2_receptor_alpha	13,41	interleukin-2	69,82	interleukin-2 receptor alpha	interleukin-2	3559	3558	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of interleukin-2_receptor_alpha -LRB- IL-2Ralpha -RRB- expression by interleukin-2 : important role of the interleukin-2_receptor_beta chain region between the two Stat5 docking sites .
8835120	0	interleukin-3	19,32	CD4	101,104	interleukin-3	CD4	3562	920	Gene	Gene	START_ENTITY|acl|circulating circulating|dobj|cells cells|nummod|END_ENTITY	Gene expression of interleukin-3 and granulocyte_macrophage_colony-stimulating_factor in circulating CD4 + T cells in acute severe asthma .
15730392	0	interleukin-3	77,90	CD8	125,128	interleukin-3	CD8	3562	925	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Mature dendritic cells differentiated in the presence of interferon-beta and interleukin-3 prime functional antigen-specific CD8 T cells .
16133111	0	interleukin-3	44,57	CD8	86,89	interleukin-3	CD8	3562	925	Gene	Gene	generated|nmod|START_ENTITY vaccine|acl|generated induces|nsubj|vaccine induces|dobj|responses responses|nummod|END_ENTITY	A new dendritic cell vaccine generated with interleukin-3 and interferon-beta induces CD8 + T cell responses against NA17-A2 tumor peptide in melanoma patients .
10524205	0	interleukin-3	73,86	DUB-1	111,116	interleukin-3	DUB-1	16187(Tax:10090)	13531(Tax:10090)	Gene	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Analysis of cis-acting sequences and trans-acting factors regulating the interleukin-3 response element of the DUB-1 gene .
7687894	0	interleukin-3	37,50	Fibrinogen	0,10	interleukin-3	Fibrinogen	3562	2244	Gene	Gene	effect|nmod|START_ENTITY potentiates|dobj|effect potentiates|nsubj|END_ENTITY	Fibrinogen potentiates the effect of interleukin-3 on early human hematopoietic progenitors .
2453230	0	interleukin-3	19,32	G-CSF	77,82	interleukin-3	G-CSF	3562	1440	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro .
8639879	0	interleukin-3	72,85	GM-CSF	144,150	interleukin-3	GM-CSF	16187(Tax:10090)	12981(Tax:10090)	Gene	Gene	IL-3|amod|START_ENTITY IL-3|appos|END_ENTITY	Extracellular truncations of h beta_c , the common signaling subunit for interleukin-3 -LRB- IL-3 -RRB- , granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , and IL-5 , lead to ligand-independent activation .
1450413	0	interleukin-3	49,62	Granulocyte-macrophage_colony-stimulating_factor	0,48	interleukin-3	Granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	protein|amod|START_ENTITY enhances|nsubj|protein END_ENTITY|appos|enhances	Granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein -LRB- pIXY 321 -RRB- enhances high-dose Ara-C-induced programmed_cell_death or apoptosis in human myeloid_leukemia cells .
10331436	0	interleukin-3	4,17	IL-3	19,23	interleukin-3	IL-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CNS interleukin-3 -LRB- IL-3 -RRB- expression and neurological_syndrome in antisense-IL-3 transgenic_mice .
10477686	0	interleukin-3	55,68	IL-3	70,74	interleukin-3	IL-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Heterodimerization of the alpha and beta chains of the interleukin-3 -LRB- IL-3 -RRB- receptor is necessary and sufficient for IL-3-induced mitogenesis .
3501044	0	interleukin-3	61,74	IL-3	76,80	interleukin-3	IL-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Transfection of a factor-dependent cell line with the murine interleukin-3 -LRB- IL-3 -RRB- cDNA results in autonomous growth and tumorigenesis .
7889941	0	interleukin-3	9,22	IL-3	24,28	interleukin-3	IL-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Impaired interleukin-3 -LRB- IL-3 -RRB- response of the A/J mouse is caused by a branch point deletion in the IL-3_receptor alpha subunit gene .
8167335	0	interleukin-3	18,31	IL-3	33,37	interleukin-3	IL-3	3562	3562	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Regulation of the interleukin-3 -LRB- IL-3 -RRB- receptor by IL-3 in the fetal liver-derived FL5 .12 cell line .
8246974	0	interleukin-3	51,64	IL-3	66,70	interleukin-3	IL-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	chain|amod|START_ENTITY chain|appos|END_ENTITY	Hematopoietic_cell_phosphatase associates with the interleukin-3 -LRB- IL-3 -RRB- receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis .
7540883	0	interleukin-3	29,42	Interferon-gamma	0,16	interleukin-3	Interferon-gamma	3562	3458	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interferon-gamma upregulates interleukin-3 -LRB- IL-3 -RRB- receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production .
8156003	0	interleukin-3	25,38	Interferon-gamma	0,16	interleukin-3	Interferon-gamma	3562	3458	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Interferon-gamma induces interleukin-3 release from peripheral blood eosinophils .
7522518	0	interleukin-3	97,110	Stem_cell_factor	0,16	interleukin-3	Stem cell factor	3562	4254	Gene	Gene	extent|nmod|START_ENTITY enhances|nmod|extent enhances|nsubj|END_ENTITY	Stem_cell_factor enhances the growth of primitive erythroid progenitors to a greater extent than interleukin-3 in patients with aplastic_anaemia .
8605334	0	interleukin-3	26,39	Stem_cell_factor	0,16	interleukin-3	Stem cell factor	3562	4254	Gene	Gene	dependent|amod|START_ENTITY induction|amod|dependent enhances|dobj|induction enhances|nsubj|END_ENTITY	Stem_cell_factor enhances interleukin-3 dependent induction of 68-kD calmodulin-binding_protein and thymidine kinase activity in NFS-60 cells .
21732357	0	interleukin-3	55,68	c-Fos	87,92	interleukin-3	c-Fos	3562	2353	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Inhibitory regulation of osteoclast differentiation by interleukin-3 via regulation of c-Fos and Id protein expression .
10477722	0	interleukin-3	135,148	granulocyte-macrophage_colony-stimulating_factor	76,124	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	sequence|amod|START_ENTITY sequence|nmod|chain chain|nmod|END_ENTITY	Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , interleukin-3 -LRB- IL-3 -RRB- , and IL-5 receptors that is serine-phosphorylated by GM-CSF .
11313280	0	interleukin-3	19,32	granulocyte-macrophage_colony-stimulating_factor	33,81	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|dep|beta-chain beta-chain|amod|END_ENTITY	Down-regulation of interleukin-3 / granulocyte-macrophage_colony-stimulating_factor receptor beta-chain in BCR-ABL -LRB- + -RRB- human leukemic cells : association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibition .
1696146	0	interleukin-3	145,158	granulocyte-macrophage_colony-stimulating_factor	80,128	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	cyclic_hematopoiesis|amod|START_ENTITY cyclic_hematopoiesis|nmod|END_ENTITY	A comparison of treatment of canine cyclic_hematopoiesis with recombinant human granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- , G-CSF interleukin-3 , and canine G-CSF .
1698795	0	interleukin-3	6,19	granulocyte-macrophage_colony-stimulating_factor	44,92	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|the the|nmod|END_ENTITY	Human interleukin-3 inhibits the binding of granulocyte-macrophage_colony-stimulating_factor and interleukin-5 to basophils and strongly enhances their functional activity .
2015572	0	interleukin-3	76,89	granulocyte-macrophage_colony-stimulating_factor	27,75	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	protein|amod|START_ENTITY /|dobj|protein /|nsubj|effects effects|nmod|END_ENTITY	Hematopoietic effects of a granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein .
7579364	0	interleukin-3	96,109	granulocyte-macrophage_colony-stimulating_factor	25,73	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	receptors|nmod|START_ENTITY express|dobj|receptors express|nsubj|Neutrophils Neutrophils|acl|activated activated|nmod|END_ENTITY	Neutrophils activated by granulocyte-macrophage_colony-stimulating_factor express receptors for interleukin-3 which mediate class II expression .
8151315	0	interleukin-3	71,84	granulocyte-macrophage_colony-stimulating_factor	22,70	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Effects of PIXY321 , a granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein , on chemotherapy-induced multilineage myelosuppression in patients with sarcoma .
9490056	0	interleukin-3	131,144	granulocyte-macrophage_colony-stimulating_factor	82,130	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	protein|amod|START_ENTITY expressed|nsubj|protein Characterization|parataxis|expressed Characterization|nmod|microheterogeneities microheterogeneities|appos|END_ENTITY	Characterization of the microheterogeneities of PIXY321 , a genetically engineered granulocyte-macrophage_colony-stimulating_factor / interleukin-3 fusion protein expressed in yeast .
9694696	0	interleukin-3	73,86	granulocyte-macrophage_colony-stimulating_factor	24,72	interleukin-3	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	beta|dep|START_ENTITY beta|amod|END_ENTITY	Defective expression of granulocyte-macrophage_colony-stimulating_factor / interleukin-3 / interleukin-5 receptor common beta chain in children with acute_myeloid_leukemia associated with respiratory_failure .
7475901	0	interleukin-3	68,81	granulocyte-macrophage_colony_stimulating_factor	19,67	interleukin-3	granulocyte-macrophage colony stimulating factor	3562	1437	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Influence of human granulocyte-macrophage_colony_stimulating_factor / interleukin-3 fusion protein -LRB- PIXY321 -RRB- on the hematopoietic_toxicity associated with anti-viral drugs -LRB- zidovudine and didanosine -RRB- in vitro using normal human marrow cells .
11196663	0	interleukin-3	25,38	hIL3	40,44	interleukin-3	hIL3	3562	3562	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two polymorphisms within interleukin-3 -LRB- hIL3 -RRB- gene detected by mismatch PCR/RFLP .
3118864	0	interleukin-3	38,51	interferon-gamma	10,26	interleukin-3	interferon-gamma	24495(Tax:10116)	25712(Tax:10116)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the space shuttle .
1462123	0	interleukin-3	57,70	interleukin-2	42,55	interleukin-3	interleukin-2	3562	3558	Gene	Gene	interferon-gamma|amod|START_ENTITY Spontaneous|appos|interferon-gamma Spontaneous|nmod|transcription transcription|nmod|END_ENTITY	Spontaneous in vivo gene transcription of interleukin-2 , interleukin-3 , interleukin-4 , interleukin-6 , _ interferon-gamma , _ interleukin-2_receptor -LRB- CD25 -RRB- and proto-oncogene_c-myc by rheumatoid synovial T lymphocytes .
3088729	0	interleukin-3	81,94	interleukin-2	32,45	interleukin-3	interleukin-2	3562	3558	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|receptor receptor|compound|END_ENTITY	Regulation of expression of the interleukin-2 receptor on hematopoietic cells by interleukin-3 .
3928979	0	interleukin-3	5,18	interleukin-2	61,74	interleukin-3	interleukin-2	16187(Tax:10090)	16183(Tax:10090)	Gene	Gene	dependent|amod|START_ENTITY lines|amod|dependent respond|nsubj|lines respond|nmod|END_ENTITY	Some interleukin-3 dependent mast-cell lines also respond to interleukin-2 .
8443757	0	interleukin-3	31,44	interleukin-2	81,94	interleukin-3	interleukin-2	3562	3558	Gene	Gene	START_ENTITY|nmod|activation activation|acl|induced induced|nmod|END_ENTITY	In vitro modulatory effects of interleukin-3 on macrophage activation induced by interleukin-2 .
9569233	0	interleukin-3	91,104	interleukin-2	76,89	interleukin-3	interleukin-2	3562	3558	Gene	Gene	colony-stimulating_factor|dep|START_ENTITY colony-stimulating_factor|compound|END_ENTITY	Interleukin-5 mRNA stability in human T cells is regulated differently than interleukin-2 , interleukin-3 , interleukin-4 , _ granulocyte/macrophage _ colony-stimulating_factor , _ and_interferon-gamma .
1710148	0	interleukin-3	185,198	stem_cell_factor	18,34	interleukin-3	stem cell factor	3562	4254	Gene	Gene	cultured|advcl|START_ENTITY enhances|parataxis|cultured enhances|nsubj|END_ENTITY	Recombinant human stem_cell_factor enhances the formation of colonies by CD34 + and CD34 + lin - cells , and the generation of colony-forming cell progeny from CD34 + lin - cells cultured with interleukin-3 , granulocyte_colony-stimulating_factor , or granulocyte-macrophage_colony-stimulating_factor .
7507298	0	interleukin-3	11,24	stem_cell_factor	59,75	interleukin-3	stem cell factor	16187(Tax:10090)	17311(Tax:10090)	Gene	Gene	START_ENTITY|nmod|c-kit_ligand c-kit_ligand|appos|END_ENTITY	Effects of interleukin-3 with or without the c-kit_ligand , stem_cell_factor , on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro .
7514543	0	interleukin-3	44,57	stem_cell_factor	22,38	interleukin-3	stem cell factor	16187(Tax:10090)	17311(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of stem_cell_factor with interleukin-3 or granulocyte-macrophage_colony-stimulating_factor on the proliferation of murine primitive hematopoietic progenitors .
7522690	0	interleukin-3	74,87	stem_cell_factor	14,30	interleukin-3	stem cell factor	3562	4254	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|formation formation|compound|END_ENTITY	Inhibition of stem_cell_factor dependent formation of human mast cells by interleukin-3 and interleukin-4 .
7694867	0	interleukin-3	135,148	stem_cell_factor	117,133	interleukin-3	stem cell factor	3562	4254	Gene	Gene	proliferation|amod|START_ENTITY proliferation|dep|cells cells|nmod|END_ENTITY	Interleukin-11 stimulates the proliferation of human hematopoietic CD34 + and CD34 + CD33-DR - cells and synergizes with stem_cell_factor , interleukin-3 , and granulocyte-macrophage_colony-stimulating_factor .
20035719	0	interleukin-33	54,68	Caspase_3	0,9	interleukin-33	Caspase 3	77125(Tax:10090)	12367(Tax:10090)	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	Caspase_3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation .
24825247	0	interleukin-33	39,53	IL-33	55,60	interleukin-33	IL-33	90865	90865	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms of the interleukin-33 -LRB- IL-33 -RRB- gene are associated with ankylosing_spondylitis in Chinese individuals : a case-control pilot study .
17623648	0	interleukin-33	19,33	ST2	8,11	interleukin-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	blocks|xcomp|START_ENTITY blocks|nsubj|END_ENTITY	Soluble ST2 blocks interleukin-33 signaling in allergic_airway_inflammation .
23172891	0	interleukin-33	22,36	ST2	37,40	interleukin-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Neutralisation of the interleukin-33 / ST2 pathway ameliorates experimental colitis through enhancement of mucosal_healing in mice .
23567618	0	interleukin-33	18,32	ST2	33,36	interleukin-33	ST2	90865	6761	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Components of the interleukin-33 / ST2 system are differentially expressed and regulated in human cardiac cells and in cells of the cardiac vasculature .
23903682	0	interleukin-33	3,17	ST2	18,21	interleukin-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	An interleukin-33 / ST2 signaling deficiency reduces overt_pain-like_behaviors in mice .
24940745	0	interleukin-33	32,46	ST2	120,123	interleukin-33	ST2	77125(Tax:10090)	17082(Tax:10090)	Gene	Gene	molecules|amod|START_ENTITY presenting|dobj|molecules presenting|parataxis|characteristics characteristics|acl|blocking blocking|dobj|END_ENTITY	Virus-like particles presenting interleukin-33 molecules : Immunization characteristics and potentials of blocking IL-33 / ST2 pathway in allergic_airway_inflammation .
24777946	0	interleukin-33	24,38	Serum_amyloid_A	0,15	interleukin-33	Serum amyloid A	90865	111345(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Serum_amyloid_A induces interleukin-33 expression through an IRF7-dependent pathway .
27060290	0	interleukin-33	34,48	Tumor_necrosis_factor-a	0,23	interleukin-33	Tumor necrosis factor-a	90865	7124	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-a regulates interleukin-33 expression through extracellular_signal-regulated_kinase , p38 , and nuclear factor-kB pathways in airway epithelial cells .
27060290	0	interleukin-33	34,48	extracellular_signal-regulated_kinase	68,105	interleukin-33	extracellular signal-regulated kinase	90865	5594	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Tumor_necrosis_factor-a regulates interleukin-33 expression through extracellular_signal-regulated_kinase , p38 , and nuclear factor-kB pathways in airway epithelial cells .
21181166	0	interleukin-34	65,79	JNK	89,92	interleukin-34	JNK	146433	5599	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Proinflammatory cytokines , IL-1b and TNF-a , induce expression of interleukin-34 mRNA via JNK - and p44/42 MAPK-NF-kB pathway but not p38 pathway in osteoblasts .
24970360	0	interleukin-34	32,46	Tumor_necrosis_factor-a	0,23	interleukin-34	Tumor necrosis factor-a	76527(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-a induces interleukin-34 expression through nuclear factor - kB activation in MC3T3-E1 osteoblastic cells .
25547245	0	interleukin-34	14,28	tumor_necrosis_factor-a	111,134	interleukin-34	tumor necrosis factor-a	146433	7124	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Expression of interleukin-34 and colony_stimulating_factor-1 in the stimulated periodontal ligament cells with tumor_necrosis_factor-a UNASSIGNED : Tumor_necrosis_factor-a -LRB- TNF-a -RRB- directly and indirectly plays a crucial role in osteoclastogenesis .
9829977	0	interleukin-4	56,69	CD28	117,121	interleukin-4	CD28	3565	940	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28 .
10712670	0	interleukin-4	133,146	CD4	97,100	interleukin-4	CD4	3565	920	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|lymphocytes lymphocytes|compound|END_ENTITY	CXC_chemokine_receptor_4 expression and stromal cell-derived factor-1alpha-induced chemotaxis in CD4 + T lymphocytes are regulated by interleukin-4 and interleukin-10 .
11141321	0	interleukin-4	13,26	CD4	50,53	interleukin-4	CD4	3565	920	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|CD8 CD8|compound|END_ENTITY	Decreases in interleukin-4 secretion by invariant CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple_sclerosis .
12067309	0	interleukin-4	47,60	CD4	64,67	interleukin-4	CD4	3565	920	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Increased expression of interleukin-13 but not interleukin-4 in CD4 + cells from patients with the hyper-IgE_syndrome .
1349531	0	interleukin-4	156,169	CD4	23,26	interleukin-4	CD4	3565	920	Gene	Gene	presence|nmod|START_ENTITY cells|nmod|presence induce|nmod|cells alpha|dep|induce alpha|nsubj|Membranes Membranes|nmod|cells cells|compound|END_ENTITY	Membranes of activated CD4 + T cells expressing T cell receptor -LRB- TcR -RRB- alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4 .
1378016	0	interleukin-4	126,139	CD4	0,3	interleukin-4	CD4	3565	920	Gene	Gene	secretion|compound|START_ENTITY respond|nmod|secretion respond|nsubj|cells cells|nummod|END_ENTITY	CD4 + suppressor cells of autoimmune encephalomyelitis respond to T_cell_receptor-associated determinants on effector cells by interleukin-4 secretion .
14678204	0	interleukin-4	28,41	CD4	114,117	interleukin-4	CD4	3565	920	Gene	Gene	START_ENTITY|nmod|CD57 CD57|compound|END_ENTITY	Intracellular expression of interleukin-4 and interferon-gamma by a Mycobacterium tuberculosis antigen-stimulated CD4 + CD57 + T-cell subpopulation with memory phenotype in tuberculosis patients .
15466391	0	interleukin-4	13,26	CD4	0,3	interleukin-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|CD45RBHi CD45RBHi|compound|END_ENTITY	CD4 + CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis .
17164429	0	interleukin-4	60,73	CD4	36,39	interleukin-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	T|nmod|START_ENTITY T|nsubj|regulation regulation|nmod|END_ENTITY	Distinct regulation of autoreactive CD4 T cell expansion by interleukin-4 under conditions of lymphopenia .
17907151	0	interleukin-4	60,73	CD4	12,15	interleukin-4	CD4	3565	920	Gene	Gene	potential|amod|START_ENTITY +|nmod|potential +|nsubj|Presence Presence|nmod|CD8 CD8|compound|END_ENTITY	Presence of CD4 + CD8 + double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic_sclerosis .
19814808	0	interleukin-4	89,102	CD4	144,147	interleukin-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|antigen antigen|acl|responding responding|dobj|cells cells|nummod|END_ENTITY	Blood feeding by the Rocky Mountain spotted fever vector , Dermacentor andersoni , induces interleukin-4 expression by cognate antigen responding CD4 + T cells .
22130674	0	interleukin-4	47,60	CD4	0,3	interleukin-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|Thp5 Thp5|compound|END_ENTITY	CD4 + T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4 + T cells to direct T helper 2 cell differentiation .
22130674	0	interleukin-4	47,60	CD4	75,78	interleukin-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	CD4 + T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4 + T cells to direct T helper 2 cell differentiation .
23545299	0	interleukin-4	45,58	CD4	74,77	interleukin-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	induce|iobj|START_ENTITY induce|dobj|T T|compound|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
26798325	0	interleukin-4	110,123	CD4	34,37	interleukin-4	CD4	3565	920	Gene	Gene	produce|dobj|START_ENTITY deleterious|advcl|produce deleterious|nsubj|cells cells|compound|END_ENTITY	Interleukin-17-producing decidual CD4 + T cells are not deleterious for human pregnancy when they also produce interleukin-4 .
7589153	0	interleukin-4	32,45	CD4	12,15	interleukin-4	CD4	3565	920	Gene	Gene	produce|dobj|START_ENTITY T|ccomp|produce T|nsubj|END_ENTITY	Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions .
8566015	0	interleukin-4	56,69	CD4	84,87	interleukin-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induce|dobj|production induce|nmod|T T|compound|END_ENTITY	In susceptible mice , Leishmania_major induce very rapid interleukin-4 production by CD4 + T cells which are NK1 .1 - .
8566047	0	interleukin-4	59,72	CD4	42,45	interleukin-4	CD4	3565	920	Gene	Gene	cells|amod|START_ENTITY development|nmod|cells development|nmod|cells cells|compound|END_ENTITY	Default development of cloned human naive CD4 T cells into interleukin-4 - and interleukin-5 - producing effector cells .
8613355	0	interleukin-4	21,34	CD4	123,126	interleukin-4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	immunization|nmod|START_ENTITY reveals|nsubj|immunization reveals|ccomp|associated associated|nsubjpass|cells cells|nummod|+ +|compound|END_ENTITY	Oral immunization of interleukin-4 -LRB- IL-4 -RRB- knockout mice with a recombinant Salmonella strain or cholera_toxin reveals that CD4 + Th2 cells producing IL-6 and IL-10 are associated with mucosal immunoglobulin_A responses .
8766544	0	interleukin-4	124,137	CD4	168,171	interleukin-4	CD4	3565	920	Gene	Gene	synthesis|compound|START_ENTITY enhances|dobj|synthesis enhances|nmod|cells cells|compound|END_ENTITY	Ligation of TAPA-1 -LRB- CD81 -RRB- or major histocompatibility complex class II in co-cultures of human B and T lymphocytes enhances interleukin-4 synthesis by antigen-specific CD4 + T cells .
9079802	0	interleukin-4	62,75	CD4	36,39	interleukin-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY cells|nmod|production cells|compound|END_ENTITY	Interleukin-7 activates human naive CD4 + cells and primes for interleukin-4 production .
9392311	0	interleukin-4	65,78	CD4	13,16	interleukin-4	CD4	3565	920	Gene	Gene	production|compound|START_ENTITY subset|nmod|production cells|appos|subset Expansion|dep|cells Expansion|nmod|CD7 CD7|compound|END_ENTITY	Expansion of CD4 + CD7 - T cells , a memory subset with preferential interleukin-4 production , after bone marrow transplantation .
11014649	0	interleukin-4	11,24	CD8	154,157	interleukin-4	CD8	3565	925	Gene	Gene	expression|compound|START_ENTITY trigger|nsubj|expression trigger|dobj|development development|nmod|transplant_arteriosclerosis transplant_arteriosclerosis|nmod|absence absence|nmod|cells cells|compound|END_ENTITY	Intragraft interleukin-4 mRNA expression after short-term CD154 blockade may trigger delayed development of transplant_arteriosclerosis in the absence of CD8 + T cells .
11141321	0	interleukin-4	13,26	CD8	56,59	interleukin-4	CD8	3565	925	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Decreases in interleukin-4 secretion by invariant CD4 -LRB- - -RRB- CD8 -LRB- - -RRB- V alpha 24J alpha Q T cells in peripheral blood of patientswith relapsing-remitting multiple_sclerosis .
17907151	0	interleukin-4	60,73	CD8	16,19	interleukin-4	CD8	3565	925	Gene	Gene	potential|amod|START_ENTITY +|nmod|potential +|nsubj|Presence Presence|nmod|END_ENTITY	Presence of CD4 + CD8 + double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic_sclerosis .
9255980	0	interleukin-4	20,33	CD8	99,102	interleukin-4	CD8	3565	925	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|cells cells|amod|interferon-gamma interferon-gamma|nmod|T T|compound|END_ENTITY	Enhancing effect of interleukin-4 on the secretion of interferon-gamma by alpha s1-casein-specific CD8 + T cells .
10712670	0	interleukin-4	133,146	CXC_chemokine_receptor_4	0,24	interleukin-4	CXC chemokine receptor 4	3565	7852	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	CXC_chemokine_receptor_4 expression and stromal cell-derived factor-1alpha-induced chemotaxis in CD4 + T lymphocytes are regulated by interleukin-4 and interleukin-10 .
17875810	0	interleukin-4	48,61	FGFR-1	0,6	interleukin-4	FGFR-1	3565	2260	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin .
2152043	0	interleukin-4	13,26	Fc_epsilon_RII	65,79	interleukin-4	Fc epsilon RII	3565	2208	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of interleukin-4 and platelet-activating_factor on the Fc_epsilon_RII / CD23 expression on human monocytes .
8574170	0	interleukin-4	53,66	GM-CSF	14,20	interleukin-4	GM-CSF	3565	1437	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Inhibition of GM-CSF production by recombinant human interleukin-4 : negative regulator of hematopoiesis .
12034035	0	interleukin-4	24,37	IFN-gamma	0,9	interleukin-4	IFN-gamma	3565	3458	Gene	Gene	START_ENTITY|nsubj|downregulates downregulates|amod|END_ENTITY	IFN-gamma downregulates interleukin-4 functional activity on monocytes by multiple mechanisms .
10090403	0	interleukin-4	16,29	IFN-tau	58,65	interleukin-4	IFN-tau	280824(Tax:9913)	509166(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Upregulation of interleukin-4 and IFN-gamma expression by IFN-tau , a member of the type I IFN family .
23545299	0	interleukin-4	45,58	IL-10	67,72	interleukin-4	IL-10	16189(Tax:10090)	16153(Tax:10090)	Gene	Gene	induce|iobj|START_ENTITY induce|dobj|T T|compound|END_ENTITY	Hookworm excretory/secretory products induce interleukin-4 -LRB- IL-4 -RRB- + IL-10 + CD4 + T cell responses and suppress pathology in a mouse model of colitis .
1830499	0	interleukin-4	71,84	IL-4	86,90	interleukin-4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 -LRB- IL-4 -RRB- , IL-5 , and gamma-interferon , but not IL-2 by activated murine T cells .
18662263	0	interleukin-4	32,45	IL-4	52,56	interleukin-4	IL-4	3565	3565	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	The -589 C > T polymorphism in the interleukin-4 gene -LRB- IL-4 -RRB- is associated with a reduced risk of myocardial_infarction in young individuals .
25986324	0	interleukin-4	6,19	IL-4	21,25	interleukin-4	IL-4	101122781	101122781	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Serum interleukin-4 -LRB- IL-4 -RRB- production is associated with lower fecal egg count in parasite-resistant sheep .
25986324	0	interleukin-4	6,19	IL-4	21,25	interleukin-4	IL-4	101122781	101122781	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Serum interleukin-4 -LRB- IL-4 -RRB- production is associated with lower fecal egg count in parasite-resistant sheep .
8440075	0	interleukin-4	22,35	IL-4	37,41	interleukin-4	IL-4	3565	3565	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Suppressive effect of interleukin-4 -LRB- IL-4 -RRB- on IL-6 production by adherent rheumatoid synovial cells .
9787171	0	interleukin-4	28,41	IL-4	43,47	interleukin-4	IL-4	3565	3565	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	OX40 costimulation enhances interleukin-4 -LRB- IL-4 -RRB- expression at priming and promotes the differentiation of naive human CD4 -LRB- + -RRB- T cells into high IL-4-producing effectors .
1830499	0	interleukin-4	71,84	IL-5	93,97	interleukin-4	IL-5	16189(Tax:10090)	16191(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Dihydrotestosterone exerts a depressive influence on the production of interleukin-4 -LRB- IL-4 -RRB- , IL-5 , and gamma-interferon , but not IL-2 by activated murine T cells .
8440075	0	interleukin-4	22,35	IL-6	46,50	interleukin-4	IL-6	3565	3569	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|compound|END_ENTITY	Suppressive effect of interleukin-4 -LRB- IL-4 -RRB- on IL-6 production by adherent rheumatoid synovial cells .
12423307	0	interleukin-4	41,54	Interleukin-6	0,13	interleukin-4	Interleukin-6	3565	3569	Gene	Gene	production|nmod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and - independent mechanisms in freshly isolated human T cells .
2469502	0	interleukin-4	29,42	Interleukin-6	0,13	interleukin-4	Interleukin-6	16189(Tax:10090)	16193(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic , erythroid , myeloid , and multipotential progenitor cells .
8205398	0	interleukin-4	116,129	Interleukin-8	0,13	interleukin-4	Interleukin-8	3565	3576	Gene	Gene	effects|nmod|START_ENTITY secretion|dep|effects secretion|amod|END_ENTITY	Interleukin-8 secretion and 15-lipoxygenase activity in rheumatoid_arthritis : in vitro anti-inflammatory effects by interleukin-4 and interleukin-10 , but not by interleukin-1_receptor_antagonist_protein .
18579517	0	interleukin-4	26,39	LEF-1	0,5	interleukin-4	LEF-1	3565	51176	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element .
7664805	0	interleukin-4	55,68	Monoclonal_nonspecific_suppressor_factor_beta	0,45	interleukin-4	Monoclonal nonspecific suppressor factor beta	16189(Tax:10090)	14109(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Monoclonal_nonspecific_suppressor_factor_beta inhibits interleukin-4 secretion by a type-2 helper T cell clone .
20859068	0	interleukin-4	37,50	RhoA	13,17	interleukin-4	RhoA	3565	387	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of RhoA gene expression by interleukin-4 in cultured human bronchial smooth muscle cells .
11572871	0	interleukin-4	55,68	STAT6	116,121	interleukin-4	STAT6	3565	6778	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|site site|compound|END_ENTITY	Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site .
12082548	0	interleukin-4	15,28	STAT6	0,5	interleukin-4	STAT6	3565	6778	Gene	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	STAT6 mediates interleukin-4 growth inhibition in human breast_cancer cells .
15199062	0	interleukin-4	74,87	STAT6	0,5	interleukin-4	STAT6	3565	6778	Gene	Gene	modulates|nmod|START_ENTITY complex|acl:relcl|modulates form|dobj|complex form|nsubj|END_ENTITY	STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes .
18625883	0	interleukin-4	96,109	STAT6	110,115	interleukin-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	rejection|nmod|START_ENTITY rejection|parataxis|END_ENTITY	Graft rejection as a Th1-type process amenable to regulation by donor Th2-type cells through an interleukin-4 / STAT6 pathway .
18789870	0	interleukin-4	21,34	STAT6	96,101	interleukin-4	STAT6	3565	6778	Gene	Gene	Expression|nmod|START_ENTITY inhibits|nsubj|Expression inhibits|nmod|END_ENTITY	Expression of canine interleukin-4 in canine chondrocytes inhibits inflammatory cascade through STAT6 .
9786931	0	interleukin-4	56,69	STAT6	0,5	interleukin-4	STAT6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	STAT6 is required for the anti-inflammatory activity of interleukin-4 in mouse peritoneal macrophages .
15805299	0	interleukin-4	28,41	Stat3	9,14	interleukin-4	Stat3	3565	6774	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Aberrant Stat3 signaling by interleukin-4 in malignant_glioma cells : involvement of IL-13Ralpha2 .
10364072	0	interleukin-4	34,47	Stat6	0,5	interleukin-4	Stat6	3565	6778	Gene	Gene	induction|compound|START_ENTITY essential|nmod|induction essential|nsubj|activation activation|amod|END_ENTITY	Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells .
10373589	0	interleukin-4	54,67	Stat6	87,92	interleukin-4	Stat6	3565	6778	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6 .
19929568	0	interleukin-4	10,23	Stat6	24,29	interleukin-4	Stat6	3565	6778	Gene	Gene	START_ENTITY|parataxis|correlates correlates|nsubj|activity activity|amod|END_ENTITY	Defective interleukin-4 / Stat6 activity correlates with increased constitutive expression of negative regulators SOCS-3 , SOCS-7 , and CISH in colon_cancer cells .
9845517	0	interleukin-4	21,34	Stat6	0,5	interleukin-4	Stat6	3565	6778	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Stat6 inhibits human interleukin-4 promoter activity in T cells .
22130674	0	interleukin-4	47,60	Thp5	34,38	interleukin-4	Thp5	3565	70123(Tax:10090)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	CD4 + T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4 + T cells to direct T helper 2 cell differentiation .
11687571	0	interleukin-4	21,34	Yin-Yang_1	0,10	interleukin-4	Yin-Yang 1	3565	7528	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Yin-Yang_1 activates interleukin-4 gene expression in T cells .
9414268	0	interleukin-4	36,49	c-Cbl	0,5	interleukin-4	c-Cbl	3565	867	Gene	Gene	tyrosine-phosphorylated|nmod|START_ENTITY tyrosine-phosphorylated|nsubjpass|END_ENTITY	c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3 ' - kinase pathway .
7918061	0	interleukin-4	18,31	granulocyte-macrophage_colony_stimulating_factor	59,107	interleukin-4	granulocyte-macrophage colony stimulating factor	3565	1437	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|nmod|END_ENTITY	Recombinant human interleukin-4 inhibits the production of granulocyte-macrophage_colony_stimulating_factor by blood mononuclear cells .
24459328	0	interleukin-4	27,40	inducible_nitric_oxide_synthase	50,81	interleukin-4	inducible nitric oxide synthase	16189(Tax:10090)	18126(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Anti-inflammatory cytokine interleukin-4 inhibits inducible_nitric_oxide_synthase gene expression in the mouse macrophage cell line RAW264 .7 through the repression of octamer-dependent transcription .
9305869	0	interleukin-4	81,94	insulin_receptor_substrate_1	37,65	interleukin-4	insulin receptor substrate 1	3565	3667	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Janus kinase-dependent activation of insulin_receptor_substrate_1 in response to interleukin-4 , oncostatin_M , and the interferons .
12127417	0	interleukin-4	24,37	interferon-gamma	68,84	interleukin-4	interferon-gamma	751514(Tax:9685)	493965(Tax:9685)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation by feline interleukin-4 and down-regulation by feline interferon-gamma of major histocompatibility complex class II on cat B-lymphocytes .
19689732	0	interleukin-4	106,119	interferon-gamma	120,136	interleukin-4	interferon-gamma	3565	3458	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Domain analyses of the Runx1 transcription factor responsible for modulating T-cell receptor-beta/CD4 and interleukin-4 / interferon-gamma expression in CD4 -LRB- + -RRB- peripheral T lymphocytes .
8766562	0	interleukin-4	28,41	interleukin-2	75,88	interleukin-4	interleukin-2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|not not|nmod|END_ENTITY	Early message expression of interleukin-4 and interferon-gamma , but not of interleukin-2 and interleukin-10 , reflects later polarization of primary CD4 + T cell cultures .
8765032	0	interleukin-4	24,37	interleukin-4	42,55	interleukin-4	interleukin-4	3565	3565	Gene	Gene	START_ENTITY|nmod|induction induction|compound|END_ENTITY	A strict requirement of interleukin-4 for interleukin-4 induction in antigen-stimulated human memory T cells .
8765032	0	interleukin-4	42,55	interleukin-4	24,37	interleukin-4	interleukin-4	3565	3565	Gene	Gene	induction|compound|START_ENTITY END_ENTITY|nmod|induction	A strict requirement of interleukin-4 for interleukin-4 induction in antigen-stimulated human memory T cells .
8156004	0	interleukin-4	42,55	interleukin-5	14,27	interleukin-4	interleukin-5	3565	3567	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|amod|END_ENTITY	Regulation of interleukin-5 production by interleukin-4 , interferon-alpha , transforming_growth_factor-beta and interleukin-6 .
16690518	0	interleukin-4	108,121	interleukin-6	123,136	interleukin-4	interleukin-6	3565	3569	Gene	Gene	interleukin-2|appos|START_ENTITY interleukin-2|amod|END_ENTITY	Aggressive_non-Hodgkin 's _ lymphoma : concomitant evaluation of interleukin-2 , soluble interleukin-2 receptor , interleukin-4 , interleukin-6 , interleukin-10 and correlation with outcome .
1912557	0	interleukin-4	14,27	interleukin-6	76,89	interleukin-4	interleukin-6	16189(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY Regulation|nmod|receptors myeloid|nsubj|Regulation myeloid|advcl|END_ENTITY	Regulation of interleukin-4 receptors on murine myeloid progenitor cells by interleukin-6 .
8464242	0	interleukin-4	21,34	interleukin-6	150,163	interleukin-4	interleukin-6	3565	3569	Gene	Gene	effect|nmod|START_ENTITY effect|dep|role role|nmod|END_ENTITY	Inhibitory effect of interleukin-4 on the proliferation of acute_myeloid_leukemia cells with myelo-monocytic differentiation -LRB- AML-M4 / M5 -RRB- ; the role of interleukin-6 .
9763548	0	interleukin-4	21,34	macrophage-derived_chemokine	59,87	interleukin-4	macrophage-derived chemokine	3565	6367	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|production production|amod|END_ENTITY	Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived_chemokine production : an amplification circuit of polarized T helper 2 responses .
16251181	0	interleukin-4	88,101	osteoprotegerin	150,165	interleukin-4	osteoprotegerin	16189(Tax:10090)	18383(Tax:10090)	Gene	Gene	resorption|nmod|START_ENTITY Inhibition|acl|resorption associated|nsubjpass|Inhibition associated|nmod|END_ENTITY	Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway .
14678201	0	interleukin-4	37,50	polymeric_immunoglobulin_receptor	77,110	interleukin-4	polymeric immunoglobulin receptor	3565	397315(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Nuclear_factor-kappaB contributes to interleukin-4 - and interferon-dependent polymeric_immunoglobulin_receptor expression in human intestinal epithelial cells .
24107646	0	interleukin-4	18,31	signal_transducer_and_activator_of_transcription_6	32,82	interleukin-4	signal transducer and activator of transcription 6	3565	6778	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|signaling signaling|nsubj|END_ENTITY	Activation of the interleukin-4 / signal_transducer_and_activator_of_transcription_6 signaling pathway and homeodomain-interacting_protein_kinase_2 production by tonsillar mononuclear cells in IgA_nephropathy .
2390123	0	interleukin-4	14,27	transforming_growth_factor_beta	47,78	interleukin-4	transforming growth factor beta	3565	7040	Gene	Gene	levels|compound|START_ENTITY levels|nmod|levels levels|nmod|END_ENTITY	Low levels of interleukin-4 and high levels of transforming_growth_factor_beta in rheumatoid_synovitis .
18722671	0	interleukin-4	58,71	tumor_necrosis_factor-alpha	10,37	interleukin-4	tumor necrosis factor-alpha	3565	7124	Gene	Gene	concentrations|compound|START_ENTITY concentrations|nmod|concentrations concentrations|amod|END_ENTITY	Increased tumor_necrosis_factor-alpha concentrations with interleukin-4 concentrations in exacerbations of schizophrenia .
8413882	0	interleukin-4	85,98	tumor_necrosis_factor-alpha	129,156	interleukin-4	tumor necrosis factor-alpha	3565	7124	Gene	Gene	glioblastoma|nmod|START_ENTITY Modulation|nmod|glioblastoma Modulation|nmod|interferon-gamma interferon-gamma|amod|END_ENTITY	Modulation of proliferation and antigen expression of a cloned human glioblastoma by interleukin-4 alone and in combination with tumor_necrosis_factor-alpha and/or interferon-gamma .
17302909	0	interleukin-4	10,23	vascular_endothelial_growth_factor	27,61	interleukin-4	vascular endothelial growth factor	3565	7422	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of interleukin-4 on vascular_endothelial_growth_factor production in rheumatoid synovial fibroblasts .
11277615	0	interleukin-4_receptor	62,84	Epidermal_growth_factor	0,23	interleukin-4 receptor	Epidermal growth factor	3566	1950	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Epidermal_growth_factor regulates astrocyte expression of the interleukin-4_receptor via a MAPK-independent pathway .
1319084	0	interleukin-4_receptor	33,55	IL4R	57,61	interleukin-4 receptor	IL4R	3566	3566	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Histological distribution of the interleukin-4_receptor -LRB- IL4R -RRB- within the normal and pathological synovium .
1679753	0	interleukin-4_receptor	4,26	IL4R	33,37	interleukin-4 receptor	IL4R	3566	3566	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The interleukin-4_receptor gene -LRB- IL4R -RRB- maps to 16p11.2-16p12 .1 in human and to the distal region of mouse chromosome 7 .
2297794	0	interleukin-5	15,28	BCL1	67,71	interleukin-5	BCL1	16191(Tax:10090)	12443(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|cells cells|compound|END_ENTITY	Interaction of interleukin-5 with its receptors on murine leukemic BCL1 cells and its implication in biological activity .
15271374	0	interleukin-5	6,19	CBP/p300	89,97	interleukin-5	CBP/p300	3567	1387;2033	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP , NF-AT and AP-1 .
11038777	0	interleukin-5	47,60	CD4	15,18	interleukin-5	CD4	3567	920	Gene	Gene	-RSB-|amod|START_ENTITY lymphocyte|nmod|-RSB- lymphocyte|nsubj|Activation Activation|nmod|T T|compound|END_ENTITY	-LSB- Activation of CD4 T lymphocyte and release of interleukin-5 in airway from patients with atopic_asthmatics -RSB- .
16266865	0	interleukin-5	43,56	CD4	60,63	interleukin-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Interleukin-9 stimulates the production of interleukin-5 in CD4 + T cells .
16780678	0	interleukin-5	52,65	CD4	131,134	interleukin-5	CD4	24497(Tax:10116)	24932(Tax:10116)	Gene	Gene	antisense|amod|START_ENTITY carrying|dobj|antisense vector|acl|carrying Effects|nmod|vector Effects|nmod|lymphocytes lymphocytes|compound|END_ENTITY	-LSB- Effects of recombinant adeno-virus vector carrying interleukin-5 antisense on the expression of interleukin-5 mRNA and protein in CD4 + T lymphocytes of asthmatic rats -RSB- .
16780678	0	interleukin-5	97,110	CD4	131,134	interleukin-5	CD4	24497(Tax:10116)	24932(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY Effects|nmod|mRNA Effects|nmod|lymphocytes lymphocytes|compound|END_ENTITY	-LSB- Effects of recombinant adeno-virus vector carrying interleukin-5 antisense on the expression of interleukin-5 mRNA and protein in CD4 + T lymphocytes of asthmatic rats -RSB- .
18686101	0	interleukin-5	8,21	CD4	47,50	interleukin-5	CD4	3567	920	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Reduced interleukin-5 production by peripheral CD4 + T cells in common variable immunodeficiency patients .
7642218	0	interleukin-5	14,27	CD4	42,45	interleukin-5	CD4	16191(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Occurrence of interleukin-5 production by CD4 - CD8 - -LRB- double-negative -RRB- T cells in lungs of both normal and congenitally athymic nude_mice infected with Toxocara_canis .
8095124	0	interleukin-5	90,103	CD4	0,3	interleukin-5	CD4	3567	920	Gene	Gene	concentrations|nmod|START_ENTITY accompanied|nmod|concentrations accompanied|nsubjpass|activation activation|nummod|END_ENTITY	CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5 .
8567949	0	interleukin-5	68,81	CD4	91,94	interleukin-5	CD4	3567	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Recombinant interferon-alpha selectively inhibits the production of interleukin-5 by human CD4 + T cells .
9217826	0	interleukin-5	79,92	CD4	51,54	interleukin-5	CD4	3567	920	Gene	Gene	mRNA|amod|START_ENTITY expressing|dobj|mRNA CD7|parataxis|expressing CD7|compound|END_ENTITY	Wells ' _ syndrome : a pathogenic role for circulating CD4 + CD7 - T cells expressing interleukin-5 mRNA .
9563728	0	interleukin-5	83,96	CD4	111,114	interleukin-5	CD4	3567	920	Gene	Gene	production|amod|START_ENTITY enhance|dobj|production enhance|nmod|cells cells|compound|END_ENTITY	Alveolar macrophages from atopic asthmatics , but not atopic nonasthmatics , enhance interleukin-5 production by CD4 + T cells .
7935454	0	interleukin-5	37,50	IL-5	52,56	interleukin-5	IL-5	16191(Tax:10090)	16191(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A critical cytoplasmic domain of the interleukin-5 -LRB- IL-5 -RRB- receptor alpha chain and its function in IL-5-mediated growth signal transduction .
8110039	0	interleukin-5	28,41	IL-5	43,47	interleukin-5	IL-5	3567	3567	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	-LSB- Protein phosphorylation in interleukin-5 -LRB- IL-5 -RRB- - stimulated human peripheral blood eosinophils -RSB- .
11197112	0	interleukin-5	20,33	Interleukin-1_beta	0,18	interleukin-5	Interleukin-1 beta	3567	3553	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Interleukin-1_beta , interleukin-5 , interleukin-6 , interleukin-8 , and tumor_necrosis_factor-alpha in chronic sinusitis : response to systemic corticosteroids .
9242874	0	interleukin-5	14,27	Interleukin-3	0,13	interleukin-5	Interleukin-3	3567	3562	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Interleukin-3 interleukin-5 , and granulocyte-macrophage_colony-stimulating_factor expression in nasal_polyps .
16266865	0	interleukin-5	43,56	Interleukin-9	0,13	interleukin-5	Interleukin-9	16191(Tax:10090)	16198(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-9 stimulates the production of interleukin-5 in CD4 + T cells .
11807001	0	interleukin-5	12,25	Stat3	112,117	interleukin-5	Stat3	3567	6774	Gene	Gene	production|amod|START_ENTITY mediated|nsubjpass|production mediated|nmod|END_ENTITY	Spontaneous interleukin-5 production in cutaneous_T-cell_lymphoma lines is mediated by constitutively activated Stat3 .
15826950	0	interleukin-5	14,27	glucocorticoid_receptor	49,72	interleukin-5	glucocorticoid receptor	3567	2908	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Repression of interleukin-5 transcription by the glucocorticoid_receptor targets GATA3 signaling and involves histone_deacetylase recruitment .
10036172	0	interleukin-5	42,55	hIL-5	57,62	interleukin-5	hIL-5	3567	3567	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	A scintillation proximity assay for human interleukin-5 -LRB- hIL-5 -RRB- high-affinity binding in insect cells coexpressing hIL-5 receptor alpha and beta subunits .
10852530	0	interleukin-5	6,19	immunoglobulin_E	21,37	interleukin-5	immunoglobulin E	3567	3497	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Nasal interleukin-5 , immunoglobulin_E , eosinophilic cationic protein , and soluble intercellular adhesion molecule-1 in chronic sinusitis , allergic_rhinitis , and nasal_polyposis .
24115031	0	interleukin-5	65,78	inhibitor_of_differentiation_3	24,54	interleukin-5	inhibitor of differentiation 3	16191(Tax:10090)	15903(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Helix-loop-helix factor inhibitor_of_differentiation_3 regulates interleukin-5 expression and B-1a B cell proliferation .
16236975	0	interleukin-5	56,69	interleukin-13	78,92	interleukin-5	interleukin-13	16191(Tax:10090)	16163(Tax:10090)	Gene	Gene	START_ENTITY|dep|dependent dependent|amod|END_ENTITY	Pneumothorax-associated pleural_eosinophilia in mice is interleukin-5 but not interleukin-13 dependent .
8156004	0	interleukin-5	14,27	interleukin-4	42,55	interleukin-5	interleukin-4	3567	3565	Gene	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of interleukin-5 production by interleukin-4 , interferon-alpha , transforming_growth_factor-beta and interleukin-6 .
11197112	0	interleukin-5	20,33	interleukin-6	35,48	interleukin-5	interleukin-6	3567	3569	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Interleukin-1_beta , interleukin-5 , interleukin-6 , interleukin-8 , and tumor_necrosis_factor-alpha in chronic sinusitis : response to systemic corticosteroids .
18206982	0	interleukin-5	20,33	thrombin	8,16	interleukin-5	thrombin	3567	2147	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of thrombin in interleukin-5 expression from basophils .
16373656	0	interleukin-6	121,134	ADAM-9	0,6	interleukin-6	ADAM-9	3569	8754	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	ADAM-9 -LRB- MDC-9 / meltrin-gamma -RRB- , a member of the a disintegrin and metalloproteinase family , regulates myeloma-cell-induced interleukin-6 production in osteoblasts by direct interaction with the alpha -LRB- v -RRB- beta5 integrin .
18795895	0	interleukin-6	20,33	Adiponectin	0,11	interleukin-6	Adiponectin	16193(Tax:10090)	11450(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Adiponectin induces interleukin-6 production and activates STAT3 in adult mouse cardiac fibroblasts .
23210469	0	interleukin-6	13,26	Adiponectin	0,11	interleukin-6	Adiponectin	3569	9370	Gene	Gene	factors|amod|START_ENTITY factors|compound|END_ENTITY	Adiponectin , interleukin-6 , and cardiovascular_disease risk factors are modified by a short-term yoga-based lifestyle intervention in overweight and obese men .
9514921	0	interleukin-6	26,39	Adrenomedullin	0,14	interleukin-6	Adrenomedullin	16193(Tax:10090)	11535(Tax:10090)	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Adrenomedullin stimulates interleukin-6 production in Swiss_3T3 cells .
19034873	0	interleukin-6	16,29	Albumin	0,7	interleukin-6	Albumin	3569	213	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells .
15059919	0	interleukin-6	42,55	Androgen_receptor	0,17	interleukin-6	Androgen receptor	3569	367	Gene	Gene	inhibition|amod|START_ENTITY mechanism|nmod|inhibition signaling|dep|mechanism signaling|compound|END_ENTITY	Androgen_receptor signaling : mechanism of interleukin-6 inhibition .
10189357	0	interleukin-6	23,36	Angiotensin_II	0,14	interleukin-6	Angiotensin II	24498(Tax:10116)	24179(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	Angiotensin_II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors .
11557673	0	interleukin-6	119,132	Angiotensin_II	0,14	interleukin-6	Angiotensin II	16193(Tax:10090)	11606(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY uptake|dep|role increases|dobj|uptake increases|nsubj|administration administration|compound|END_ENTITY	Angiotensin_II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl : a possible role for interleukin-6 .
15130920	0	interleukin-6	41,54	Angiotensin_II	0,14	interleukin-6	Angiotensin II	3569	183	Gene	Gene	release|acl|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates the release of interleukin-6 and interleukin-8 from cultured human adipocytes by activation of NF-kappaB .
17043157	0	interleukin-6	23,36	Angiotensin_II	0,14	interleukin-6	Angiotensin II	3569	183	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism .
21109230	0	interleukin-6	23,36	Angiotensin_II	0,14	interleukin-6	Angiotensin II	16193(Tax:10090)	11606(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Angiotensin_II induces interleukin-6 synthesis in osteoblasts through ERK1/2 pathway via AT1 receptor .
7579076	0	interleukin-6	26,39	Angiotensin_II	0,14	interleukin-6	Angiotensin II	16193(Tax:10090)	11606(Tax:10090)	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates interleukin-6 release from cultured mouse mesangial cells .
2788466	0	interleukin-6	27,40	BSF-2	47,52	interleukin-6	BSF-2	3569	3569	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Pathogenic significance of interleukin-6 -LRB- IL-6 / BSF-2 -RRB- in Castleman 's _ disease .
22725135	0	interleukin-6	34,47	B_cell-activating_factor	0,24	interleukin-6	B cell-activating factor	3569	10673	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	B_cell-activating_factor enhances interleukin-6 and interleukin-10 production by ODN-activated human B cells .
9376229	0	interleukin-6	39,52	Basic_fibroblast_growth_factor	0,30	interleukin-6	Basic fibroblast growth factor	16193(Tax:10090)	14173(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces interleukin-6 synthesis in osteoblasts : autoregulation by protein_kinase_C .
8024566	0	interleukin-6	75,88	Beta_2-microglobulin	0,20	interleukin-6	Beta 2-microglobulin	3569	567	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Beta_2-microglobulin modified with advanced glycation end products induces interleukin-6 from human macrophages : role in the pathogenesis of hemodialysis-associated amyloidosis .
10501190	0	interleukin-6	19,32	Bradykinin	0,10	interleukin-6	Bradykinin	3569	3827	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear_factor-kappaB .
12594059	0	interleukin-6	19,32	Bradykinin	0,10	interleukin-6	Bradykinin	3569	3827	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Bradykinin induces interleukin-6 production in human airway_smooth_muscle cells : modulation by Th2 cytokines and dexamethasone .
1932373	0	interleukin-6	19,32	Bradykinin	0,10	interleukin-6	Bradykinin	3569	3827	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Bradykinin induces interleukin-6 and synergizes with interleukin-1 .
9141588	0	interleukin-6	22,35	Bradykinin	0,10	interleukin-6	Bradykinin	3569	3827	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Bradykinin stimulates interleukin-6 and interleukin-8 secretion of human decidua derived cells .
10476751	0	interleukin-6	46,59	C-reactive_protein	76,94	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Assessment of measuring circulating levels of interleukin-6 , interleukin-8 , C-reactive_protein , soluble Fc gamma receptor type III , and mannose-binding_protein in febrile children with cancer and neutropenia .
11053781	0	interleukin-6	81,94	C-reactive_protein	49,67	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Alpha_tocopherol supplementation decreases serum C-reactive_protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients .
11922913	0	interleukin-6	43,56	C-reactive_protein	107,125	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	gene|amod|START_ENTITY polymorphism|nmod|gene Genotype|nmod|polymorphism associated|nsubjpass|Genotype associated|nmod|levels levels|nmod|END_ENTITY	Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive_protein .
12519862	0	interleukin-6	38,51	C-reactive_protein	110,128	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	expression|amod|START_ENTITY regulating|dobj|expression polymorphisms|acl|regulating associated|nsubjpass|polymorphisms associated|advcl|circulating circulating|dobj|levels levels|nmod|END_ENTITY	Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive_protein and markers of bone resorption in postmenopausal women .
12826933	0	interleukin-6	21,34	C-reactive_protein	76,94	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nmod|monocytes monocytes|acl|stimulated stimulated|nmod|END_ENTITY	Simvastatin inhibits interleukin-6 release in human monocytes stimulated by C-reactive_protein and lipopolysaccharide .
15069709	0	interleukin-6	35,48	C-reactive_protein	0,18	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	C-reactive_protein , procalcitonin , interleukin-6 , vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric_cancer .
15781013	0	interleukin-6	11,24	C-reactive_protein	75,93	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	Effects|nmod|START_ENTITY produced|nsubj|Effects produced|nmod|production production|nmod|END_ENTITY	Effects of interleukin-6 produced in coronary circulation on production of C-reactive_protein and coronary microvascular resistance .
16876827	0	interleukin-6	52,65	C-reactive_protein	79,97	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	signaling|amod|START_ENTITY blocks|dobj|signaling blocks|nmod|expression expression|amod|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- blocks the interleukin-6 signaling to C-reactive_protein expression in Hep3B cells by suppressing Rac-1 activation .
17003778	0	interleukin-6	88,101	C-reactive_protein	68,86	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	The longitudinal relationship between circulating concentrations of C-reactive_protein , interleukin-6 and interleukin-10 in patients undergoing resection for renal_cancer .
18653160	0	interleukin-6	41,54	C-reactive_protein	21,39	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	index|compound|START_ENTITY Correlations|appos|index Correlations|nmod|END_ENTITY	Correlations between C-reactive_protein , interleukin-6 , tumor_necrosis_factor-alpha and body mass index during senile_osteoporosis .
19267250	0	interleukin-6	20,33	C-reactive_protein	0,18	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	risk|amod|START_ENTITY risk|amod|END_ENTITY	C-reactive_protein , interleukin-6 , and prostate_cancer risk in men aged 65 years and older .
19489963	0	interleukin-6	96,109	C-reactive_protein	76,94	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	concentrations|amod|START_ENTITY concentrations|nmod|END_ENTITY	Flow mediated vasodilation and circulating concentrations of high sensitive C-reactive_protein , interleukin-6 and tumor_necrosis_factor-alpha in normal pregnancy -- The Cardiovascular Risk in Young Finns Study .
19811958	0	interleukin-6	29,42	C-reactive_protein	62,80	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	test|amod|START_ENTITY Usefulness|nmod|test combined|nsubj|Usefulness combined|nmod|END_ENTITY	-LSB- Usefulness of a rapid serum interleukin-6 test combined with C-reactive_protein to predict sepsis in newborns with suspicion of infection -RSB- .
2154496	0	interleukin-6	36,49	C-reactive_protein	60,78	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	responsible|advcl|START_ENTITY elements|amod|responsible inducible|nsubj|elements inducible|dobj|expression expression|amod|END_ENTITY	cis-acting elements responsible for interleukin-6 inducible C-reactive_protein gene expression .
21550586	0	interleukin-6	133,146	C-reactive_protein	24,42	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	stimulated|advcl|START_ENTITY cells|acl|stimulated derived|nmod|cells derived|nsubjpass|expression expression|nmod|gene gene|amod|END_ENTITY	Increased expression of C-reactive_protein gene in inflamed gingival tissues could be derived from endothelial cells stimulated with interleukin-6 .
21597715	0	interleukin-6	74,87	C-reactive_protein	20,38	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	concentrations|amod|START_ENTITY circulating|dobj|concentrations occur|advcl|circulating occur|nsubj|Elevations Elevations|nmod|END_ENTITY	Elevations of serum C-reactive_protein occur independently of circulating interleukin-6 concentrations in patients with lung-cancer .
21735293	0	interleukin-6	78,91	C-reactive_protein	14,32	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	tumor_necrosis_factor_alpha|nummod|START_ENTITY tumor_necrosis_factor_alpha|compound|END_ENTITY	Evaluation of C-reactive_protein , procalcitonin , tumor_necrosis_factor_alpha , interleukin-6 , and interleukin-8 as diagnostic parameters in sepsis-related fatalities .
22223149	0	interleukin-6	27,40	C-reactive_protein	0,18	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	protein|amod|START_ENTITY induces|dobj|protein induces|nsubj|END_ENTITY	C-reactive_protein induces interleukin-6 and thrombospondin-1 protein and mRNA expression through activation of nuclear factor - B in HK-2 cells .
23124693	0	interleukin-6	124,137	C-reactive_protein	32,50	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	rate|amod|START_ENTITY index|appos|rate correlate|nmod|index correlate|nsubj|levels levels|amod|END_ENTITY	Elevated serum high-sensitivity C-reactive_protein levels in fibromyalgia_syndrome patients correlate with body mass index , interleukin-6 , interleukin-8 , erythrocyte sedimentation rate .
23757905	0	interleukin-6	48,61	C-reactive_protein	28,46	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	leukocyte|amod|START_ENTITY leukocyte|amod|END_ENTITY	Estimation of the levels of C-reactive_protein , interleukin-6 , total leukocyte count , and differential count in peripheral blood smear of patients with chronic_periodontitis in a South Indian population .
24338120	0	interleukin-6	21,34	C-reactive_protein	36,54	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Umbilical cord serum interleukin-6 , C-reactive_protein , and myeloperoxidase concentrations at birth and association with neonatal morbidities and long-term neurodevelopmental outcomes .
24749795	0	interleukin-6	26,39	C-reactive_protein	41,59	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	status|amod|START_ENTITY status|amod|END_ENTITY	Maternal plasma levels of interleukin-6 , C-reactive_protein , vitamins_C , _ E_and_A , 8-isoprostane and oxidative status in women with preterm premature rupture_of_membranes .
24836084	0	interleukin-6	20,33	C-reactive_protein	0,18	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	soluble|amod|START_ENTITY necrosis|amod|soluble necrosis|amod|END_ENTITY	C-reactive_protein , interleukin-6 , soluble tumor necrosis factor a receptor 2 and incident clinical depression .
25963492	0	interleukin-6	49,62	C-reactive_protein	29,47	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	serum_amyloid_A|amod|START_ENTITY serum_amyloid_A|amod|END_ENTITY	Evaluation of procalcitonin , C-reactive_protein , interleukin-6 _ serum_amyloid_A as diagnostic biomarkers of bacterial_infection in febrile patients .
26190096	0	interleukin-6	101,114	C-reactive_protein	66,84	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	levels|amod|START_ENTITY Comparison|appos|levels Comparison|nmod|efficacy efficacy|nmod|parameters parameters|nmod|END_ENTITY	Comparison of the efficacy of new leukocyte parameters with serum C-reactive_protein , procalcitonin , interleukin-6 levels in the diagnosis of neonatal_sepsis .
7627386	0	interleukin-6	33,46	C-reactive_protein	55,73	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	induced|amod|START_ENTITY reduces|iobj|induced reduces|dobj|synthesis synthesis|amod|END_ENTITY	Ranitidine reduces postoperative interleukin-6 induced C-reactive_protein synthesis .
8306367	0	interleukin-6	56,69	C-reactive_protein	119,137	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	START_ENTITY|nmod|I I|dep|induction induction|nmod|END_ENTITY	Immune function of patients receiving recombinant human interleukin-6 -LRB- IL-6 -RRB- in a phase I clinical study : induction of C-reactive_protein and IgE and inhibition of natural killer and lymphokine-activated killer cell activity .
8621622	0	interleukin-6	83,96	C-reactive_protein	56,74	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	participates|advcl|START_ENTITY participates|nmod|activation activation|nmod|gene gene|amod|END_ENTITY	STAT3 participates in transcriptional activation of the C-reactive_protein gene by interleukin-6 .
9645918	0	interleukin-6	21,34	C-reactive_protein	81,99	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Postoperative plasma interleukin-6 in patients with renal_cancer correlates with C-reactive_protein but not with total fibrinogen or with high molecular weight fibrinogen fraction .
9804463	0	interleukin-6	65,78	C-reactive_protein	7,25	interleukin-6	C-reactive protein	3569	1401	Gene	Gene	production|amod|START_ENTITY backfiltration|dobj|production linked|xcomp|backfiltration linked|nsubjpass|END_ENTITY	Plasma C-reactive_protein is linked to backfiltration associated interleukin-6 production .
24472318	0	interleukin-6	95,108	C/EBP-b	21,28	interleukin-6	C/EBP-b	3569	1051	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Transcription factor C/EBP-b mediates downregulation of dipeptidyl-peptidase_III expression by interleukin-6 in human glioblastoma cells .
9607842	0	interleukin-6	34,47	C3a	5,8	interleukin-6	C3a	3569	718	Gene	Gene	synthesis|amod|START_ENTITY regulate|dobj|synthesis regulate|nsubj|END_ENTITY	Both C3a and C3a -LRB- desArg -RRB- regulate interleukin-6 synthesis in human peripheral blood mononuclear cells .
10929868	0	interleukin-6	45,58	C5a	0,3	interleukin-6	C5a	3569	728	Gene	Gene	production|amod|START_ENTITY modulation|nmod|production modulation|amod|END_ENTITY	C5a modulation of interleukin-1_beta-induced interleukin-6 production by human osteoblast-like cells .
11875003	0	interleukin-6	104,117	C5a	27,30	interleukin-6	C5a	24498(Tax:10116)	362119(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY mediation|nmod|cells Induction|dep|mediation Induction|nmod|receptors receptors|amod|END_ENTITY	Induction of anaphylatoxin C5a receptors in rat hepatocytes by lipopolysaccharide in vivo : mediation by interleukin-6 from Kupffer cells .
1499642	0	interleukin-6	71,84	C5a	18,21	interleukin-6	C5a	3569	728	Gene	Gene	synthesis|nmod|START_ENTITY enhances|dobj|synthesis enhances|nsubj|END_ENTITY	Human recombinant C5a enhances lipopolysaccharide-induced synthesis of interleukin-6 by human monocytes .
1769685	0	interleukin-6	19,32	C5a	12,15	interleukin-6	C5a	3569	728	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	The role of C5a in interleukin-6 production induced by lipopolysaccharide or interleukin-1 .
23469772	0	interleukin-6	12,25	CD14	35,39	interleukin-6	CD14	3569	929	Gene	Gene	soluble|amod|START_ENTITY END_ENTITY|amod|soluble	Circulating interleukin-6 , soluble CD14 , and other inflammation biomarker levels differ between obese and nonobese_HIV-infected adults on antiretroviral therapy .
12571422	0	interleukin-6	134,147	CD4	83,86	interleukin-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY insights|nmod|role model|dep|insights model|nmod|chronic_colitis chronic_colitis|nmod|mice mice|acl|induced induced|nmod|transfer transfer|nmod|cells cells|compound|END_ENTITY	A new model of chronic_colitis in SCID mice induced by adoptive transfer of CD62L + CD4 + T cells : insights into the regulatory role of interleukin-6 on apoptosis .
16340466	0	interleukin-6	136,149	CD4	12,15	interleukin-6	CD4	3569	920	Gene	Gene	genes|amod|START_ENTITY polymorphisms|nmod|genes associated|nmod|polymorphisms associated|nsubjpass|Recovery Recovery|nmod|Cells Cells|compound|END_ENTITY	Recovery of CD4 + T Cells in HIV patients with a stable virologic response to antiretroviral therapy is associated with polymorphisms of interleukin-6 and central major histocompatibility complex genes .
1656094	0	interleukin-6	82,95	CD4	110,113	interleukin-6	CD4	3569	920	Gene	Gene	production|amod|START_ENTITY induce|dobj|production induce|nmod|clones clones|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoproteins gp120 and gp160 induce interleukin-6 production in CD4 + T-cell clones .
24944284	0	interleukin-6	82,95	CD4	122,125	interleukin-6	CD4	16193(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	n-3 PUFAs reduce T-helper 17 cell differentiation by decreasing responsiveness to interleukin-6 in isolated mouse splenic CD4 T cells .
8301219	0	interleukin-6	22,35	CD4	15,18	interleukin-6	CD4	3569	920	Gene	Gene	secretion|amod|START_ENTITY Involvement|nmod|secretion Involvement|nmod|END_ENTITY	Involvement of CD4 in interleukin-6 secretion by U937 monocytic cells stimulated with the lectin jacalin .
9090764	0	interleukin-6	76,89	CD4	37,40	interleukin-6	CD4	3569	920	Gene	Gene	factors|amod|START_ENTITY cells|nmod|factors +|dobj|cells +|nsubj|Relations Relations|nmod|number number|nmod|CD29 CD29|compound|END_ENTITY	Relations between absolute number of CD4 + CD29 + memory cells and levels of interleukin-6 , rheumatoid factors , and acute phase proteins in rheumatoid synovial fluid .
11886848	0	interleukin-6	13,26	CD40	0,4	interleukin-6	CD40	3569	958	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	CD40 induces interleukin-6 gene transcription in dendritic cells : regulation by TRAF2 , AP-1 , NF-kappa B , AND CBF1 .
12571422	0	interleukin-6	134,147	CD62L	76,81	interleukin-6	CD62L	16193(Tax:10090)	20343(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY insights|nmod|role model|dep|insights model|nmod|chronic_colitis chronic_colitis|nmod|mice mice|acl|induced induced|nmod|transfer transfer|nmod|cells cells|compound|END_ENTITY	A new model of chronic_colitis in SCID mice induced by adoptive transfer of CD62L + CD4 + T cells : insights into the regulatory role of interleukin-6 on apoptosis .
11140882	0	interleukin-6	21,34	CD95	49,53	interleukin-6	CD95	3569	355	Gene	Gene	START_ENTITY|nmod|Fas Fas|appos|END_ENTITY	Effect of endogenous interleukin-6 on Fas -LRB- APO-1 / CD95 -RRB- receptor expression in advanced melanoma patients .
20181940	0	interleukin-6	34,47	CO2	9,12	interleukin-6	CO2	3569	717	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Elevated CO2 selectively inhibits interleukin-6 and tumor_necrosis_factor expression and decreases phagocytosis in the macrophage .
16809483	0	interleukin-6	12,25	COX-2	77,82	interleukin-6	COX-2	24498(Tax:10116)	29527(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain .
17197193	0	interleukin-6	24,37	Cardiotrophin-1	0,15	interleukin-6	Cardiotrophin-1	3569	1489	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells .
17637508	0	interleukin-6	24,37	Cardiotrophin-1	0,15	interleukin-6	Cardiotrophin-1	3569	1489	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Cardiotrophin-1 induces interleukin-6 synthesis in human monocytes .
10704080	0	interleukin-6	41,54	Cyclosporin_A	0,13	interleukin-6	Cyclosporin A	3569	1161	Gene	Gene	synthesis|amod|START_ENTITY decreases|dobj|synthesis decreases|nsubj|END_ENTITY	Cyclosporin_A decreases human macrophage interleukin-6 synthesis at post-transcriptional level .
7823269	0	interleukin-6	27,40	Cyclosporine_A	0,14	interleukin-6	Cyclosporine A	3569	1161	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Cyclosporine_A upregulates interleukin-6 gene expression in human gingiva : possible mechanism for gingival_overgrowth .
10452539	0	interleukin-6	59,72	Endothelin-1	0,12	interleukin-6	Endothelin-1	24498(Tax:10116)	24323(Tax:10116)	Gene	Gene	family|amod|START_ENTITY induces|nmod|family induces|nsubj|END_ENTITY	Endothelin-1 induces expression of fetal genes through the interleukin-6 family of cytokines in cardiac myocytes .
10826501	0	interleukin-6	21,34	Endothelin-1	0,12	interleukin-6	Endothelin-1	3569	1906	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-kappaB in human vascular smooth muscle cells .
19162127	0	interleukin-6	24,37	Endothelin-1	0,12	interleukin-6	Endothelin-1	16193(Tax:10090)	13614(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates interleukin-6 secretion from 3T3-L1 adipocytes .
8889860	0	interleukin-6	14,27	Endothelin-1	0,12	interleukin-6	Endothelin-1	3569	1906	Gene	Gene	levels|amod|START_ENTITY increase|nsubj|levels increase|advmod|END_ENTITY	Endothelin-1 , interleukin-6 , and interleukin-8 levels increase in patients with burns .
9590694	0	interleukin-6	39,52	ErbB2	15,20	interleukin-6	ErbB2	3569	2064	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Requirement of ErbB2 for signalling by interleukin-6 in prostate_carcinoma cells .
16043358	0	interleukin-6	27,40	Estrogen_receptor	0,17	interleukin-6	Estrogen receptor	3569	2099	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Estrogen_receptor inhibits interleukin-6 gene expression by disruption of nuclear factor kappaB transactivation .
22633286	0	interleukin-6	36,49	FHL2	21,25	interleukin-6	FHL2	3569	2274	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The LIM-only protein FHL2 regulates interleukin-6 expression through p38 MAPK mediated NF-kB pathway in muscle cells .
15502643	0	interleukin-6	38,51	Fibroblast_growth_factor-2	0,26	interleukin-6	Fibroblast growth factor-2	3569	2247	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Fibroblast_growth_factor-2 stimulates interleukin-6 secretion in human pancreatic periacinar myofibroblasts .
25129106	0	interleukin-6	124,137	GPR68	110,115	interleukin-6	GPR68	24498(Tax:10116)	314386(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Proton receptor GPR68 expression in dendritic-cell-like S100b-positive cells of rat anterior pituitary gland : GPR68 induces interleukin-6 gene expression in extracellular acidification .
22977256	0	interleukin-6	24,37	Glycodelin-A	0,12	interleukin-6	Glycodelin-A	3569	5047	Gene	Gene	secretion|amod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Glycodelin-A stimulates interleukin-6 secretion by human monocytes and macrophages through L-selectin and the extracellular signal-regulated kinase pathway .
12909491	0	interleukin-6	63,76	Gonadotropin-releasing_hormone	0,30	interleukin-6	Gonadotropin-releasing hormone	3569	2796	Gene	Gene	concentrations|amod|START_ENTITY reduced|dobj|concentrations reduced|nsubj|treatment treatment|amod|END_ENTITY	Gonadotropin-releasing_hormone agonist treatment reduced serum interleukin-6 concentrations in patients with ovarian_endometriomas .
12372336	0	interleukin-6	51,64	Gp130	0,5	interleukin-6	Gp130	3569	3572	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Gp130 activation by soluble interleukin-6_receptor / interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells .
9143707	0	interleukin-6	14,27	Gp130	0,5	interleukin-6	Gp130	3569	3572	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	Gp130 and the interleukin-6 family of cytokines .
9921985	0	interleukin-6	55,68	Gp130	31,36	interleukin-6	Gp130	3569	3572	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|chain chain|amod|END_ENTITY	Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin_M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity .
8954036	0	interleukin-6	25,38	Growth_hormone	0,14	interleukin-6	Growth hormone	3569	2688	Gene	Gene	increases|amod|START_ENTITY increases|amod|END_ENTITY	Growth_hormone increases interleukin-6 produced by human osteoblast-like cells .
19071214	0	interleukin-6	71,84	Hepatocyte_growth_factor	0,24	interleukin-6	Hepatocyte growth factor	16193(Tax:10090)	15234(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|nmod|expression induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces delayed STAT3 phosphorylation through interleukin-6 expression .
21072211	0	interleukin-6	35,48	Hepatocyte_growth_factor	0,24	interleukin-6	Hepatocyte growth factor	16193(Tax:10090)	15234(Tax:10090)	Gene	Gene	production|amod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Hepatocyte_growth_factor modulates interleukin-6 production in bone marrow derived macrophages : implications for inflammatory mediated diseases .
3136546	0	interleukin-6	36,49	IFN_beta_2	57,67	interleukin-6	IFN beta 2	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Cloning and expression of the human interleukin-6 -LRB- BSF-2 / IFN_beta_2 -RRB- receptor .
7482719	0	interleukin-6	16,29	IL-2	60,64	interleukin-6	IL-2	3569	3558	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	The relation of interleukin-6 , tumor_necrosis_factor-alpha , IL-2 , and IL-2_receptor levels to cellular rejection , allograft_dysfunction , and clinical events early after cardiac transplantation .
10194431	0	interleukin-6	8,21	IL-6	23,27	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Soluble interleukin-6 -LRB- IL-6 -RRB- receptor with IL-6 stimulates megakaryopoiesis from human CD34 -LRB- + -RRB- cells through glycoprotein _ -LRB- gp -RRB- 130 signaling .
10340760	0	interleukin-6	8,21	IL-6	34,38	interleukin-6	IL-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression .
10541568	0	interleukin-6	11,24	IL-6	26,30	interleukin-6	IL-6	3569	3569	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of interleukin-6 -LRB- IL-6 -RRB- on cytotrophoblastic cells .
10580802	0	interleukin-6	56,69	IL-6	71,75	interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms at - 174 and in the 3 ' flanking region of interleukin-6 -LRB- IL-6 -RRB- gene in patients with myasthenia_gravis .
10833369	0	interleukin-6	91,104	IL-6	106,110	interleukin-6	IL-6	3569	3569	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Pregnancy-dependent expression of leukaemia_inhibitory_factor -LRB- LIF -RRB- , LIF receptor-beta and interleukin-6 -LRB- IL-6 -RRB- messenger ribonucleic_acids in the porcine female reproductive tract .
11022130	0	interleukin-6	160,173	IL-6	175,179	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11083315	0	interleukin-6	87,100	IL-6	102,106	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 -LRB- IL-6 -RRB- levels .
11766126	0	interleukin-6	12,25	IL-6	27,31	interleukin-6	IL-6	3569	3569	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of interleukin-6 -LRB- IL-6 -RRB- in human_sulfur_mustard -LRB- HD -RRB- toxicology .
11884403	0	interleukin-6	16,29	IL-6	31,35	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
12036196	0	interleukin-6	49,62	IL-6	64,68	interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An -LRB- CA -RRB- n dinucleotide repeat polymorphism of the interleukin-6 -LRB- IL-6 -RRB- gene is associated with metacarpal bone_mineral_density in hemodialysis patients .
12414762	0	interleukin-6	86,99	IL-6	101,105	interleukin-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	NK cells mediate increase of phagocytic activity but not of proinflammatory cytokine -LRB- interleukin-6 -LSB- IL-6 -RSB- , tumor_necrosis_factor_alpha , and IL-12 -RRB- production elicited in splenic macrophages by tilorone treatment of mice during acute systemic_candidiasis .
12633863	0	interleukin-6	10,23	IL-6	25,29	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The human interleukin-6 -LRB- IL-6 -RRB- receptor exists as a preformed dimer in the plasma membrane .
12829785	0	interleukin-6	40,53	IL-6	54,58	interleukin-6	IL-6	3569	3569	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Hexameric structure and assembly of the interleukin-6 / IL-6 alpha-receptor/gp130 complex .
14592424	0	interleukin-6	8,21	IL-6	49,53	interleukin-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Chronic interleukin-6 -LRB- IL-6 -RRB- treatment increased IL-6 secretion and induced insulin resistance in adipocyte : prevention by rosiglitazone .
14668030	0	interleukin-6	20,33	IL-6	35,39	interleukin-6	IL-6	3569	3569	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Platelet counts and interleukin-6 -LRB- IL-6 -RRB- promoter polymorphism in patients with Gaucher_disease .
1479760	0	interleukin-6	84,97	IL-6	99,103	interleukin-6	IL-6	3569	3569	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Establishment of a new human renal_cancer cell line -LRB- TC-1 -RRB- and its productivity of interleukin-6 -LRB- IL-6 -RRB- -RSB- .
15086213	0	interleukin-6	45,58	IL-6	60,64	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Effect of octreotide administration on serum interleukin-6 -LRB- IL-6 -RRB- levels of patients with acute edematous_pancreatitis .
15319170	0	interleukin-6	40,53	IL-6	55,59	interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The C-174G promoter polymorphism of the interleukin-6 -LRB- IL-6 -RRB- gene that affects insulin sensitivity in Caucasians is not involved in the pathogenesis of Taiwanese_type_2_diabetes mellitus .
15455667	0	interleukin-6	9,22	IL-6	24,28	interleukin-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	-LSB- Role of interleukin-6 -LRB- IL-6 -RRB- in the pathogenesis of combined radiation/thermal injuries -RSB- .
1586734	0	interleukin-6	26,39	IL-6	128,132	interleukin-6	IL-6	3569	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY Introduction|nmod|receptor restores|nsubj|Introduction restores|nmod|END_ENTITY	Introduction of the human interleukin-6 -LRB- IL-6 -RRB- receptor in murine IL-3-dependent hematopoietic cells restores responsiveness to IL-6 .
1586734	0	interleukin-6	26,39	IL-6	41,45	interleukin-6	IL-6	3569	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Introduction of the human interleukin-6 -LRB- IL-6 -RRB- receptor in murine IL-3-dependent hematopoietic cells restores responsiveness to IL-6 .
16927176	0	interleukin-6	16,29	IL-6	31,35	interleukin-6	IL-6	3569	3569	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of interleukin-6 -LRB- IL-6 -RRB- in breast_cancer -LRB- review -RRB- .
16956953	0	interleukin-6	49,62	IL-6	124,128	interleukin-6	IL-6	4961449(Tax:37296)	3569	Gene	Gene	transduction|nmod|START_ENTITY Signal|acl|transduction modulated|nsubjpass|Signal modulated|nmod|subunit subunit|nmod|complex complex|compound|END_ENTITY	Signal transduction by human_herpesvirus_8 viral interleukin-6 -LRB- vIL-6 -RRB- is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6 .
17283116	0	interleukin-6	23,36	IL-6	38,42	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Establishment of a new interleukin-6 -LRB- IL-6 -RRB- receptor inhibitor applicable to the gene therapy for IL-6-dependent tumor .
17303263	0	interleukin-6	26,39	IL-6	41,45	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Prognostic value of serum interleukin-6 -LRB- IL-6 -RRB- levels in long term care .
17500617	0	interleukin-6	7,20	IL-6	33,37	interleukin-6	IL-6	3569	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Plasma interleukin-6 and soluble IL-6 receptors are associated with psychological_well-being in aging women .
18030875	0	interleukin-6	26,39	IL-6	41,45	interleukin-6	IL-6	3569	3569	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	-LSB- Clinical significance of interleukin-6 -LRB- IL-6 -RRB- as a prognostic factor of cancer_disease -RSB- .
19261461	0	interleukin-6	29,42	IL-6	44,48	interleukin-6	IL-6	3569	3569	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Highly specific detection of interleukin-6 -LRB- IL-6 -RRB- protein using combination tapered fiber-optic biosensor dip-probe .
20627334	0	interleukin-6	62,75	IL-6	77,81	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Muscle strength , muscle balance , physical function and plasma interleukin-6 -LRB- IL-6 -RRB- levels in elderly women with knee_osteoarthritis -LRB- OA -RRB- .
2107195	0	interleukin-6	42,55	IL-6	57,61	interleukin-6	IL-6	3569	3569	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Normal mitogen-induced suppression of the interleukin-6 -LRB- IL-6 -RRB- response and its deficiency in systemic_lupus_erythematosus .
21127061	0	interleukin-6	13,26	IL-6	28,32	interleukin-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nrf2 induces interleukin-6 -LRB- IL-6 -RRB- expression via an antioxidant response element within the IL-6 promoter .
21277639	0	interleukin-6	17,30	IL-6	32,36	interleukin-6	IL-6	3569	3569	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Distributions of interleukin-6 -LRB- IL-6 -RRB- promoter and metallothionein_2A -LRB- MT2A -RRB- core promoter region gene polymorphisms and their associations with aging in Turkish population .
21523377	0	interleukin-6	22,35	IL-6	37,41	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Regulation of soluble interleukin-6 -LRB- IL-6 -RRB- receptor release from corneal epithelial cells and its role in the ocular surface .
21607393	0	interleukin-6	27,40	IL-6	42,46	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Origin of heterogeneity of interleukin-6 -LRB- IL-6 -RRB- levels in malignant_pleural_effusions .
21911244	0	interleukin-6	15,28	IL-6	30,34	interleukin-6	IL-6	3569	3569	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Effects of the interleukin-6 -LRB- IL-6 -RRB- polymorphism on toxic metal and trace element levels in placental tissues .
21976681	0	interleukin-6	145,158	IL-6	160,164	interleukin-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Efnb1 and Efnb2 proteins regulate thymocyte development , peripheral T cell differentiation , and antiviral immune responses and are essential for interleukin-6 -LRB- IL-6 -RRB- signaling .
22135910	0	interleukin-6	10,23	IL-6	25,29	interleukin-6	IL-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of interleukin-6 -LRB- IL-6 -RRB- on the vascular smooth muscle contraction in abdominal aorta of rats with streptozotocin-induced diabetes .
22157761	0	interleukin-6	84,97	IL-6	99,103	interleukin-6	IL-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_3|amod|START_ENTITY signal_transducer_and_activator_of_transcription_3|appos|END_ENTITY	Inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- attenuates interleukin-6 -LRB- IL-6 -RRB- - induced collagen synthesis and resultant hypertrophy in rat heart .
22457007	0	interleukin-6	69,82	IL-6	84,88	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Baseline anti-citrullinated peptide antibody -LRB- ACPA -RRB- titers and serum interleukin-6 -LRB- IL-6 -RRB- levels possibly predict progression_of_bone_destruction in early stages of rheumatoid_arthritis -LRB- ERA -RRB- .
22773460	0	interleukin-6	22,35	IL-6	37,41	interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Impact of the -174 G/C interleukin-6 -LRB- IL-6 -RRB- gene polymorphism on the risk of paediatric ischemic_stroke , its symptoms and outcome .
23398417	0	interleukin-6	61,74	IL-6	76,80	interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , expression and regulation analysis of the interleukin-6 -LRB- IL-6 -RRB- gene in goose adipocytes .
2392639	1	interleukin-6	65,78	IL-6	108,112	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Raised serum interleukin-6 -LRB- IL-6 -RRB- levels and effects of IL-6 and anti-IL-6 on in vitro erythropoiesis .
24709011	0	interleukin-6	64,77	IL-6	79,83	interleukin-6	IL-6	3569	3569	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TLR5 activation by flagellin induces doxorubicin_resistance via interleukin-6 -LRB- IL-6 -RRB- expression in two multiple myeloma cells .
26255596	0	interleukin-6	24,37	IL-6	39,43	interleukin-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Glycoprotein130 -LRB- Gp130 -RRB- / interleukin-6 -LRB- IL-6 -RRB- signalling in osteoclasts promotes bone formation in periosteal and trabecular bone .
7559874	0	interleukin-6	8,21	IL-6	23,27	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Soluble interleukin-6 -LRB- IL-6 -RRB- receptor in the sera of pregnant women forms a complex with IL-6 and augments human chorionic gonadotropin production by normal human trophoblasts through binding to the IL-6 signal transducer .
7768358	0	interleukin-6	8,21	IL-6	23,27	interleukin-6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Soluble interleukin-6 -LRB- IL-6 -RRB- receptor augments central effects of IL-6 in vivo .
8074468	0	interleukin-6	16,29	IL-6	31,35	interleukin-6	IL-6	3569	3569	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Augmentation of interleukin-6 -LRB- IL-6 -RRB- expression in squamous_carcinoma cells and normal human keratinocytes treated with recombinant anti-neoplastic_protein -LRB- ACP -RRB- .
8325885	0	interleukin-6	24,37	IL-6	48,52	interleukin-6	IL-6	3569	3569	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Modulation of the human interleukin-6 promoter -LRB- IL-6 -RRB- and transcription factor C/EBP _ beta -LRB- NF-IL6 -RRB- activity by p53 species .
8344369	0	interleukin-6	22,35	IL-6	37,41	interleukin-6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Increased circulating interleukin-6 -LRB- IL-6 -RRB- activity in endotoxin-challenged mice pretreated with anti-IL-6 antibody is due to IL-6 accumulated in antigen-antibody complexes .
8372675	0	interleukin-6	18,31	IL-6	33,37	interleukin-6	IL-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum and urinary interleukin-6 -LRB- IL-6 -RRB- levels as predicting factors of Kawasaki_disease activity .
8417972	0	interleukin-6	25,38	IL-6	40,44	interleukin-6	IL-6	24498(Tax:10116)	24498(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Absence of expression of interleukin-6 -LRB- IL-6 -RRB- mRNA in regenerating rat liver .
8621406	0	interleukin-6	49,62	IL-6	64,68	interleukin-6	IL-6	3569	3569	Gene	Gene	signal|amod|START_ENTITY signal|appos|END_ENTITY	A di-leucine motif and an upstream serine in the interleukin-6 -LRB- IL-6 -RRB- signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the IL-6 receptor .
9769329	0	interleukin-6	41,54	IL-6	56,60	interleukin-6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The effect of novel polymorphisms in the interleukin-6 -LRB- IL-6 -RRB- gene on IL-6 transcription and plasma IL-6 levels , and an association with systemic-onset juvenile_chronic_arthritis .
18001296	0	interleukin-6	4,17	IL6	19,22	interleukin-6	IL6	3569	3569	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	The interleukin-6 -LRB- IL6 -RRB- -174 _ G/C promoter genotype is associated with the presence of septic_shock and the ex vivo secretion of IL6 .
9169458	0	interleukin-6	40,53	IL6	55,58	interleukin-6	IL6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	HIV-1 Tat induces the expression of the interleukin-6 -LRB- IL6 -RRB- gene by binding to the IL6 leader RNA and by interacting with CAAT_enhancer-binding_protein beta -LRB- NF-IL6 -RRB- transcription factors .
8160012	0	interleukin-6	12,25	IgA	37,40	interleukin-6	IgA	3569	973	Gene	Gene	role|nmod|START_ENTITY role|nmod|responses responses|compound|END_ENTITY	The role of interleukin-6 in mucosal IgA antibody responses in vivo .
14532168	0	interleukin-6	19,32	Insulin	0,7	interleukin-6	Insulin	3569	3630	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Insulin stimulates interleukin-6 and tumor_necrosis_factor-alpha gene expression in human subcutaneous adipose tissue .
18617614	0	interleukin-6	19,32	Insulin	0,7	interleukin-6	Insulin	3569	3630	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes through multiple signaling pathways .
2633333	0	interleukin-6	18,31	Interferon_beta_2	0,17	interleukin-6	Interferon beta 2	3569	3569	Gene	Gene	/|amod|START_ENTITY /|compound|END_ENTITY	Interferon_beta_2 / interleukin-6 and interleukin-3 synergize in stimulating proliferation of human early hematopoietic progenitor cells .
1493810	0	interleukin-6	99,112	Interleukin-1	0,13	interleukin-6	Interleukin-1	3569	3552	Gene	Gene	effect|nmod|START_ENTITY factor|dep|effect factor|nsubj|END_ENTITY	Interleukin-1 is a motility factor for human breast_carcinoma cells in vitro : additive effect with interleukin-6 .
21795706	0	interleukin-6	37,50	Interleukin-1	0,13	interleukin-6	Interleukin-1	3569	3552	Gene	Gene	mechanism|amod|START_ENTITY synthesis|nmod|mechanism activates|dobj|synthesis activates|nsubj|END_ENTITY	Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type_splicing_regulatory_protein -LRB- KSRP -RRB- - dependent translational silencing mechanism .
2786435	0	interleukin-6	68,81	Interleukin-1	0,13	interleukin-6	Interleukin-1	3569	3552	Gene	Gene	accelerates|nmod|START_ENTITY accelerates|nsubj|END_ENTITY	Interleukin-1 accelerates autocrine growth of myeloma_cells through interleukin-6 in human myeloma .
8391194	0	interleukin-6	40,53	Interleukin-1	0,13	interleukin-6	Interleukin-1	3569	3552	Gene	Gene	cells|amod|START_ENTITY release|nmod|cells stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interleukin-1 stimulates the release of interleukin-6 from cultured human pituitary_adenoma cells .
12394188	0	interleukin-6	16,29	Interleukin-10	0,14	interleukin-6	Interleukin-10	3569	3586	Gene	Gene	polymorphisms|amod|START_ENTITY END_ENTITY|appos|polymorphisms	Interleukin-10 , interleukin-6 and interferon-gamma gene polymorphisms in melanoma patients .
18684450	0	interleukin-6	44,57	Interleukin-10	0,14	interleukin-6	Interleukin-10	3569	3586	Gene	Gene	production|amod|START_ENTITY attenuates|dobj|production attenuates|nsubj|END_ENTITY	Interleukin-10 attenuates TNF-alpha-induced interleukin-6 production in endometriotic stromal cells .
7725065	0	interleukin-6	37,50	Interleukin-10	0,14	interleukin-6	Interleukin-10	3569	3586	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-10 directly inhibits the interleukin-6 production in T-cells .
8344757	0	interleukin-6	80,93	Interleukin-10	0,14	interleukin-6	Interleukin-10	3569	3586	Gene	Gene	expression|amod|START_ENTITY production|nmod|expression production|amod|END_ENTITY	Interleukin-10 production by human carcinoma cell lines and its relationship to interleukin-6 expression .
8885776	0	interleukin-6	29,42	Interleukin-10	0,14	interleukin-6	Interleukin-10	3569	3586	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Interleukin-10 inhibition of interleukin-6 in human amniochorionic membrane : transcriptional regulation .
7909299	0	interleukin-6	26,39	Interleukin-13	0,14	interleukin-6	Interleukin-13	3569	3596	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-13 stimulates interleukin-6 production by human keratinocytes .
11197112	0	interleukin-6	35,48	Interleukin-1_beta	0,18	interleukin-6	Interleukin-1 beta	3569	3553	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Interleukin-1_beta , interleukin-5 , interleukin-6 , interleukin-8 , and tumor_necrosis_factor-alpha in chronic sinusitis : response to systemic corticosteroids .
12190816	0	interleukin-6	27,40	Interleukin-1_beta	0,18	interleukin-6	Interleukin-1 beta	3569	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_beta induces interleukin-6 mRNA expression and protein production in synovial cells from human temporomandibular_joint .
2335234	0	interleukin-6	54,67	Interleukin-1_beta	0,18	interleukin-6	Interleukin-1 beta	3569	3553	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Interleukin-1_beta induces synthesis and secretion of interleukin-6 in human chondrocytes .
7700568	0	interleukin-6	20,33	Interleukin-1_beta	0,18	interleukin-6	Interleukin-1 beta	3569	3553	Gene	Gene	elevated|nsubj|START_ENTITY elevated|advmod|END_ENTITY	Interleukin-1_beta , interleukin-6 , epidermal_growth_factor and transforming_growth_factor-alpha are elevated in the brain from parkinsonian patients .
7711382	0	interleukin-6	20,33	Interleukin-1_beta	0,18	interleukin-6	Interleukin-1 beta	3569	3553	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Interleukin-1_beta , interleukin-6 , and growth_hormone levels in human follicular fluid .
8275959	0	interleukin-6	30,43	Interleukin-1_beta	0,18	interleukin-6	Interleukin-1 beta	3569	3553	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates interleukin-6 production in placental villous core mesenchymal cells .
10467171	0	interleukin-6	26,39	Interleukin-1beta	0,17	interleukin-6	Interleukin-1beta	3569	3553	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-1beta induces interleukin-6 production through the production of prostaglandin_E -LRB- 2 -RRB- in human osteoblasts , MG-63 cells .
16202978	0	interleukin-6	26,39	Interleukin-1beta	0,17	interleukin-6	Interleukin-1beta	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	Interleukin-1beta targets interleukin-6 in progressing dextran sulfate_sodium-induced experimental colitis .
21398280	0	interleukin-6	65,78	Interleukin-1beta	0,17	interleukin-6	Interleukin-1beta	3569	3553	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-1beta increases baseline expression and secretion of interleukin-6 by human uveal melanocytes in vitro via the p38 MAPK/NF-kappaB pathway .
9927320	0	interleukin-6	63,76	Interleukin-1beta	0,17	interleukin-6	Interleukin-1beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	release|amod|START_ENTITY stimulate|dobj|release stimulate|nsubj|END_ENTITY	Interleukin-1beta and catecholamines synergistically stimulate interleukin-6 release from rat C6 glioma cells in vitro : a potential role for lysophosphatidylcholine .
10632444	0	interleukin-6	73,86	Interleukin-4	0,13	interleukin-6	Interleukin-4	3569	3565	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits granulocyte-macrophage_colony-stimulating_factor , interleukin-6 , and tumor_necrosis_factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro .
15304279	0	interleukin-6	79,92	Interleukin-4	0,13	interleukin-6	Interleukin-4	3569	3565	Gene	Gene	secretion|nmod|START_ENTITY induced|dobj|secretion induced|nsubj|interleukin-1 interleukin-1|amod|END_ENTITY	Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells .
1779891	0	interleukin-6	28,41	Interleukin-4	0,13	interleukin-6	Interleukin-4	3569	3565	Gene	Gene	production|amod|START_ENTITY downregulates|dobj|production downregulates|nsubj|END_ENTITY	Interleukin-4 downregulates interleukin-6 production by human alveolar macrophages at protein and mRNA levels .
1912585	0	interleukin-6	66,79	Interleukin-4	0,13	interleukin-6	Interleukin-4	3569	3565	Gene	Gene	expression|amod|START_ENTITY suppressing|dobj|expression inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits growth of multiple_myelomas by suppressing interleukin-6 expression .
2335755	0	interleukin-6	28,41	Interleukin-4	0,13	interleukin-6	Interleukin-4	3569	3565	Gene	Gene	production|amod|START_ENTITY downregulates|dobj|production downregulates|nsubj|END_ENTITY	Interleukin-4 downregulates interleukin-6 production in human peripheral blood mononuclear cells .
16407046	0	interleukin-6	94,107	Interleukin-4_and_13	0,20	interleukin-6	Interleukin-4 and 13	3569	3565;3596	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induce|dobj|expression induce|nsubj|END_ENTITY	Interleukin-4_and_13 induce the expression and release of monocyte_chemoattractant_protein_1 , interleukin-6 and stem_cell_factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha .
21467819	0	interleukin-6	26,39	Interleukin-6	0,13	interleukin-6	Interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Interleukin-6 and soluble interleukin-6 receptor suppress osteoclastic differentiation by inducing PGE -LRB- 2 -RRB- production in chondrocytes .
23375410	0	interleukin-6	96,109	Interleukin-6	0,13	interleukin-6	Interleukin-6	3569	3569	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Interleukin-6 in the pathogenesis of posterior capsule opacification and the potential role for interleukin-6 inhibition in the future of cataract surgery .
25245339	0	interleukin-6	46,59	Interleukin-6	0,13	interleukin-6	Interleukin-6	3569	3569	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	Interleukin-6 , soluble interleukin-6_receptor / interleukin-6 complex and insulin resistance in obese children and adolescents .
8770701	0	interleukin-6	26,39	Interleukin-6	0,13	interleukin-6	Interleukin-6	16193(Tax:10090)	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid_arthritis patients are responsible for osteoclast-like cell formation .
20186139	0	interleukin-6	51,64	Interleukin-6_receptor	0,22	interleukin-6	Interleukin-6 receptor	3569	3570	Gene	Gene	levels|amod|START_ENTITY modulates|dobj|levels modulates|nsubj|polymorphism polymorphism|amod|END_ENTITY	Interleukin-6_receptor gene polymorphism modulates interleukin-6 levels and the metabolic_syndrome : GBCS-CVD .
7537214	0	interleukin-6	109,122	JAK1	45,49	interleukin-6	Tyk2	3569	7297	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|dobj|END_ENTITY	A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6 .
12181114	0	interleukin-6	14,27	L-selectin	31,41	interleukin-6	L-selectin	3569	6402	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	The effect of interleukin-6 on L-selectin levels on polymorphonuclear_leukocytes .
15719623	0	interleukin-6	44,57	Leptin	0,6	interleukin-6	Leptin	3569	3952	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Leptin in acute leukaemias : relationship to interleukin-6 and vascular_endothelial_growth_factor .
23622344	0	interleukin-6	18,31	Leptin	0,6	interleukin-6	Leptin	3569	3952	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Leptin stimulates interleukin-6 production via janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 in rheumatoid synovial fibroblasts .
16105094	0	interleukin-6	68,81	Lipopolysaccharide-binding_protein	0,34	interleukin-6	Lipopolysaccharide-binding protein	3569	3929	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Lipopolysaccharide-binding_protein down-regulates the expression of interleukin-6 by human gingival fibroblast .
12067409	0	interleukin-6	55,68	MG-132	21,27	interleukin-6	MG-132	3569	875581(Tax:243273)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells enhances|dobj|expression enhances|nsubj|END_ENTITY	Proteasome inhibitor MG-132 enhances the expression of interleukin-6 in human umbilical vein endothelial cells : Involvement of MAP/ERK kinase .
19201396	0	interleukin-6	19,32	MUC1	46,50	interleukin-6	MUC1	3569	4582	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	Macrophage-derived interleukin-6 up-regulates MUC1 , but down-regulates MUC2 expression in the human colon_cancer HT-29 cell line .
11314001	0	interleukin-6	112,125	Mcl-1	57,62	interleukin-6	Mcl-1	3569	4170	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	The involvement of PI_3-K / Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6 .
21195737	0	interleukin-6	56,69	Mucin	0,5	interleukin-6	Mucin	3569	100508689	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Mucin from rheumatoid_arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells .
10226093	0	interleukin-6	38,51	NF-IL6	87,93	interleukin-6	NF-IL6	3569	1051	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-kappaB in primary human vascular smooth muscle cells .
1730090	0	interleukin-6	85,98	NF-IL6	50,56	interleukin-6	NF-IL6	3569	1051	Gene	Gene	factor|nmod|START_ENTITY expression|appos|factor expression|nmod|END_ENTITY	Macrophage differentiation-specific expression of NF-IL6 , a transcription factor for interleukin-6 .
8325885	0	interleukin-6	24,37	NF-IL6	91,97	interleukin-6	NF-IL6	3569	1051	Gene	Gene	promoter|amod|START_ENTITY Modulation|nmod|promoter C/EBP|nsubj|Modulation C/EBP|xcomp|_ _|dobj|activity activity|appos|END_ENTITY	Modulation of the human interleukin-6 promoter -LRB- IL-6 -RRB- and transcription factor C/EBP _ beta -LRB- NF-IL6 -RRB- activity by p53 species .
8441418	0	interleukin-6	21,34	NF-IL6	47,53	interleukin-6	NF-IL6	24498(Tax:10116)	24253(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A nuclear factor for interleukin-6 expression -LRB- NF-IL6 -RRB- and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction .
8455626	0	interleukin-6	55,68	NF-IL6	25,31	interleukin-6	NF-IL6	3569	1051	Gene	Gene	signaling|amod|START_ENTITY synthesis|nmod|signaling synthesis|nsubj|regulation regulation|nmod|END_ENTITY	Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic_acid signaling in embryonal_carcinoma cells .
9199508	0	interleukin-6	14,27	NF-IL6	134,140	interleukin-6	NF-IL6	3569	1051	Gene	Gene	expression|amod|START_ENTITY Repression|nmod|expression Repression|dep|inhibition inhibition|amod|END_ENTITY	Repression of interleukin-6 gene expression by 17_beta-estradiol : inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa_B by the estrogen_receptor .
9461509	0	interleukin-6	188,201	NF-IL6	34,40	interleukin-6	NF-IL6	3569	1051	Gene	Gene	mediate|advcl|START_ENTITY co-operate|xcomp|mediate pathways|xcomp|co-operate pathways|nsubj|interleukin-6 interleukin-6|appos|END_ENTITY	The nuclear factor interleukin-6 -LRB- NF-IL6 -RRB- and signal_transducer_and_activator_of_transcription-3 -LRB- STAT-3 -RRB- signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat_shock .
21127061	0	interleukin-6	13,26	Nrf2	0,4	interleukin-6	Nrf2	16193(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Nrf2 induces interleukin-6 -LRB- IL-6 -RRB- expression via an antioxidant response element within the IL-6 promoter .
10590238	0	interleukin-6	21,34	Oncostatin_M	0,12	interleukin-6	Oncostatin M	3569	5008	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Oncostatin_M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta .
21641579	0	interleukin-6	17,30	P2Y6_receptor	50,63	interleukin-6	P2Y6 receptor	3569	5031	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Pressure induces interleukin-6 expression via the P2Y6_receptor in human dental pulp cells .
16888221	0	interleukin-6	32,45	PACAP	0,5	interleukin-6	PACAP	24498(Tax:10116)	24166(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY release|nmod|cells stimulates|dobj|release stimulates|nsubj|END_ENTITY	PACAP stimulates the release of interleukin-6 in cultured rat M ller cells .
23966393	0	interleukin-6	12,25	PD-1	47,51	interleukin-6	PD-1	16193(Tax:10090)	18566(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of interleukin-6 in the expression of PD-1 and PDL-1 on central nervous system cells following infection with Theiler 's murine encephalomyelitis virus .
15649404	0	interleukin-6	19,32	PKCepsilon	0,10	interleukin-6	PKCepsilon	16193(Tax:10090)	18754(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	PKCepsilon induces interleukin-6 expression through the MAPK pathway in 3T3-L1 adipocytes .
10077343	0	interleukin-6	6,19	PTH	69,72	interleukin-6	PTH	3569	5741	Gene	Gene	relationship|dep|START_ENTITY relationship|nmod|END_ENTITY	Serum interleukin-6 in renal_osteodystrophy : relationship with serum PTH and bone remodeling markers .
11171594	0	interleukin-6	60,73	Parathyroid_hormone	0,19	interleukin-6	Parathyroid hormone	24498(Tax:10116)	24694(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Parathyroid_hormone induces hepatic production of bioactive interleukin-6 and its soluble receptor .
12185323	0	interleukin-6	28,41	Parathyroid_hormone	0,19	interleukin-6	Parathyroid hormone	24498(Tax:10116)	24694(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Parathyroid_hormone induces interleukin-6 gene expression in bone stromal cells of young rats .
21048959	0	interleukin-6	66,79	Parathyroid_hormone	0,19	interleukin-6	Parathyroid hormone	16193(Tax:10090)	19226(Tax:10090)	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|END_ENTITY	Parathyroid_hormone mediates hematopoietic cell expansion through interleukin-6 .
2548501	0	interleukin-6	128,141	Parathyroid_hormone	0,19	interleukin-6	Parathyroid hormone	24498(Tax:10116)	24694(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY cells|dep|role stimulate|nmod|cells stimulate|nsubj|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- and PTH-like_protein -LRB- PLP -RRB- stimulate interleukin-6 production by osteogenic cells : a possible role of interleukin-6 in osteoclastogenesis .
2548501	0	interleukin-6	63,76	Parathyroid_hormone	0,19	interleukin-6	Parathyroid hormone	24498(Tax:10116)	24694(Tax:10116)	Gene	Gene	production|amod|START_ENTITY stimulate|dobj|production stimulate|nsubj|END_ENTITY	Parathyroid_hormone -LRB- PTH -RRB- and PTH-like_protein -LRB- PLP -RRB- stimulate interleukin-6 production by osteogenic cells : a possible role of interleukin-6 in osteoclastogenesis .
9328832	0	interleukin-6	36,49	Parathyroid_hormone	0,19	interleukin-6	Parathyroid hormone	3569	5741	Gene	Gene	induction|amod|START_ENTITY mediated|dobj|induction END_ENTITY|acl|mediated	Parathyroid_hormone -LRB- 1-34 -RRB- - mediated interleukin-6 induction .
9763144	0	interleukin-6	28,41	Parathyroid_hormone	0,19	interleukin-6	Parathyroid hormone	16193(Tax:10090)	19226(Tax:10090)	Gene	Gene	nuclear|amod|START_ENTITY expression|nsubj|nuclear induces|xcomp|expression induces|nsubj|END_ENTITY	Parathyroid_hormone induces interleukin-6 heterogeneous nuclear and messenger RNA expression in murine calvarial organ cultures .
11830592	0	interleukin-6	76,89	Pax3	0,4	interleukin-6	Pax3	16193(Tax:10090)	18505(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Pax3 down-regulation and shut-off of melanogenesis in melanoma B16/F10 .9 by interleukin-6 receptor signaling .
15276019	0	interleukin-6	61,74	Pigment_epithelium-derived_factor	0,33	interleukin-6	Pigment epithelium-derived factor	3569	57104	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Pigment_epithelium-derived_factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation .
16427158	0	interleukin-6	80,93	Pituitary_adenylate_cyclase-activating_peptide	0,46	interleukin-6	Pituitary adenylate cyclase-activating peptide	24498(Tax:10116)	24166(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells stimulates|dobj|production stimulates|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_peptide -LRB- PACAP -RRB- stimulates production of interleukin-6 in rat M ller cells .
9165043	0	interleukin-6	109,122	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	interleukin-6	Pituitary adenylate cyclase activating polypeptide	24498(Tax:10116)	24166(Tax:10116)	Gene	Gene	production|amod|START_ENTITY stimulate|dobj|production stimulate|nsubj|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- and vasoactive intestinal peptide -LRB- VIP -RRB- stimulate interleukin-6 production through the third subtype of PACAP/VIP receptor in rat bone marrow-derived stromal cells .
1937867	0	interleukin-6	37,50	Platelet-activating_factor	0,26	interleukin-6	Platelet-activating factor	16193(Tax:10090)	109585(Tax:10090)	Gene	Gene	production|amod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Platelet-activating_factor modulates interleukin-6 production by mouse fibroblasts .
8972179	0	interleukin-6	61,74	RBP	40,43	interleukin-6	RBP	3569	57794	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The mammalian transcriptional repressor RBP -LRB- CBF1 -RRB- regulates interleukin-6 gene expression .
18586382	0	interleukin-6	62,75	Rho-kinase	15,25	interleukin-6	Rho-kinase	16193(Tax:10090)	19878(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Involvement of Rho-kinase in prostaglandin_F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts .
12176919	0	interleukin-6	88,101	Rta	0,3	interleukin-6	Rta	3569	4961526(Tax:37296)	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Rta of the human_herpesvirus_8 / Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression .
24939178	0	interleukin-6	38,51	SOD2	14,18	interleukin-6	SOD2	3569	6648	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of SOD2 and b-arrestin1 by interleukin-6 contributes to the increase of IGF-1R expression in docetaxel resistant prostate cancer cells .
12037677	0	interleukin-6	33,46	STAT3	0,5	interleukin-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	transformation|amod|START_ENTITY required|nmod|transformation required|nsubjpass|activation activation|compound|END_ENTITY	STAT3 activation is required for interleukin-6 induced transformation in tumor-promotion sensitive mouse skin epithelial cells .
16926159	0	interleukin-6	37,50	STAT3	78,83	interleukin-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|xcomp|signaling signaling|nmod|activation activation|compound|END_ENTITY	Pyrrolidine_dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes .
16939807	0	interleukin-6	58,71	STAT3	76,81	interleukin-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Delta-4 expression on a stromal cell line is augmented by interleukin-6 via STAT3 activation .
17875759	0	interleukin-6	18,31	STAT3	32,37	interleukin-6	STAT3	3569	6774	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Activation of the interleukin-6 / STAT3 antiapoptotic pathway in esophageal cells by bile_acids and low pH : relevance to barrett 's _ esophagus .
19071214	0	interleukin-6	71,84	STAT3	41,46	interleukin-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|nmod|expression induces|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Hepatocyte_growth_factor induces delayed STAT3 phosphorylation through interleukin-6 expression .
19330073	0	interleukin-6	137,150	STAT3	117,122	interleukin-6	STAT3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	action|amod|START_ENTITY attenuate|dobj|action signal_transduction_and_activation_of_transcription_3|acl|attenuate signal_transduction_and_activation_of_transcription_3|appos|END_ENTITY	Pravastatin prevents aortic_atherosclerosis via modulation of signal_transduction_and_activation_of_transcription_3 -LRB- STAT3 -RRB- to attenuate interleukin-6 -LRB- IL-6 -RRB- action in ApoE knockout mice .
22157761	0	interleukin-6	84,97	STAT3	66,71	interleukin-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	signal_transducer_and_activator_of_transcription_3|amod|START_ENTITY signal_transducer_and_activator_of_transcription_3|appos|END_ENTITY	Inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- attenuates interleukin-6 -LRB- IL-6 -RRB- - induced collagen synthesis and resultant hypertrophy in rat heart .
22522122	0	interleukin-6	64,77	STAT3	78,83	interleukin-6	STAT3	3569	6774	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Diet-derived polyphenols inhibit angiogenesis by modulating the interleukin-6 / STAT3 pathway .
23903834	0	interleukin-6	43,56	STAT3	83,88	interleukin-6	STAT3	3569	6774	Gene	Gene	signaling|dep|START_ENTITY signaling|nmod|END_ENTITY	Human_cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus .
23917204	0	interleukin-6	26,39	STAT3	73,78	interleukin-6	STAT3	3569	6774	Gene	Gene	expression|amod|START_ENTITY expression|nmod|downregulation downregulation|nmod|pathway pathway|compound|END_ENTITY	TIS21 -LRB- / BTG2/PC3 -RRB- inhibits interleukin-6 expression via downregulation of STAT3 pathway .
24912675	0	interleukin-6	60,73	STAT3	74,79	interleukin-6	STAT3	3569	6774	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	Cross talk between the TM4SF5/focal _ adhesion_kinase and the interleukin-6 / STAT3 pathways promotes immune escape of human liver_cancer cells .
25636517	0	interleukin-6	134,147	STAT3	4,9	interleukin-6	STAT3	3569	6774	Gene	Gene	induced|advcl|START_ENTITY inhibitors|acl|induced histone|dobj|inhibitors reverses|xcomp|histone reverses|nsubj|WP1066 WP1066|compound|END_ENTITY	The STAT3 inhibitor WP1066 reverses the resistance of chronic_lymphocytic_leukemia cells to histone deacetylase inhibitors induced by interleukin-6 .
25938734	0	interleukin-6	105,118	STAT3	71,76	interleukin-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Toll-like_receptor_4-mediated immune stress in pregnant rats activates STAT3 in the fetal brain : role of interleukin-6 .
26527061	0	interleukin-6	41,54	STAT3	73,78	interleukin-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY enhances|dobj|synthesis enhances|nmod|END_ENTITY	cAMP/PKA enhances interleukin-1b-induced interleukin-6 synthesis through STAT3 in glial cells .
8621622	0	interleukin-6	83,96	STAT3	0,5	interleukin-6	STAT3	3569	6774	Gene	Gene	participates|advcl|START_ENTITY participates|nsubj|END_ENTITY	STAT3 participates in transcriptional activation of the C-reactive_protein gene by interleukin-6 .
9311994	0	interleukin-6	88,101	STAT3	37,42	interleukin-6	STAT3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	stimulated|advcl|START_ENTITY cells|acl|stimulated kinase|nmod|cells kinase|nsubj|control control|nmod|outgrowth outgrowth|nmod|END_ENTITY	Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6 .
24476318	0	interleukin-6	24,37	Serum_amyloid_A	0,15	interleukin-6	Serum amyloid A	3569	6287	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Serum_amyloid_A induces interleukin-6 in dermal fibroblasts via Toll-like_receptor_2 , interleukin-1_receptor-associated_kinase_4_and_nuclear_factor-kB .
21122157	0	interleukin-6	75,88	Signal_transducer_and_activator_of_transcription_3	0,50	interleukin-6	Signal transducer and activator of transcription 3	3569	6774	Gene	Gene	production|amod|START_ENTITY up-regulates|dep|production up-regulates|amod|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 activation up-regulates interleukin-6 autocrine production : a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells .
7477764	0	interleukin-6	46,59	Somatostatin	0,12	interleukin-6	Somatostatin	3569	6750	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Somatostatin -LRB- SRIF -RRB- stimulates the release of interleukin-6 -LRB- IL-6 -RRB- from human peripheral blood monocytes -LRB- PBM -RRB- in vitro .
18348986	0	interleukin-6	30,43	Stat1/3	106,113	interleukin-6	Stat1/3	3569	6772;6774	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	The proinflammatory cytokine , interleukin-6 , up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3 .
10636920	0	interleukin-6	77,90	Stat3	18,23	interleukin-6	Stat3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells .
10845908	0	interleukin-6	124,137	Stat3	13,18	interleukin-6	Stat3	3569	6774	Gene	Gene	secretion|nmod|START_ENTITY caused|nmod|secretion caused|nsubj|END_ENTITY	Constitutive Stat3 , Tyr705 , and Ser727 phosphorylation in acute_myeloid_leukemia cells caused by the autocrine secretion of interleukin-6 .
15998296	0	interleukin-6	12,25	Stat3	105,110	interleukin-6	Stat3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY Blockade|nmod|signaling aggravates|nsubj|Blockade aggravates|parataxis|involvement involvement|nmod|activation activation|amod|END_ENTITY	Blockade of interleukin-6 signaling aggravates ischemic_cerebral_damage in mice : possible involvement of Stat3 activation in the protection of neurons .
16887796	0	interleukin-6	15,28	Stat3	0,5	interleukin-6	Stat3	3569	6774	Gene	Gene	correction|amod|START_ENTITY mediates|dobj|correction mediates|nsubj|END_ENTITY	Stat3 mediates interleukin-6 -LSB- correction of interelukin-6 -RSB- inhibition of human endothelial_nitric-oxide_synthase expression .
19437447	0	interleukin-6	19,32	Stat3	33,38	interleukin-6	Stat3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	link|nmod|START_ENTITY link|dep|anti-apoptotic anti-apoptotic|amod|END_ENTITY	A link between the interleukin-6 / Stat3 anti-apoptotic pathway and microRNA-21 in preimplantation mouse embryos .
21211286	0	interleukin-6	30,43	Stat3	44,49	interleukin-6	Stat3	3569	6774	Gene	Gene	Effects|nmod|START_ENTITY Effects|parataxis|signaling signaling|nsubj|END_ENTITY	-LSB- Effects of siltuximab on the interleukin-6 / Stat3 signaling pathway in ovarian_cancer -RSB- .
22684844	0	interleukin-6	24,37	Stat3	69,74	interleukin-6	Stat3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY partitioning|nmod|signalling dissociates|nsubj|partitioning dissociates|dobj|END_ENTITY	Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung_fibrosis .
8662645	0	interleukin-6	34,47	Stat3	80,85	interleukin-6	Stat3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	outgrowth|nmod|START_ENTITY Induction|nmod|outgrowth accompanied|nsubjpass|Induction accompanied|nmod|activation activation|nmod|END_ENTITY	Induction of neurite outgrowth by interleukin-6 is accompanied by activation of Stat3 signaling pathway in a variant PC12 cell -LRB- E2 -RRB- line .
9523575	0	interleukin-6	33,46	Substance_P	0,11	interleukin-6	Substance P	3569	6863	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Substance_P and histamine induce interleukin-6 expression in human astrocytoma cells by a mechanism involving protein kinase C and nuclear factor-IL-6 .
21762647	0	interleukin-6	8,21	TGF-b	61,66	interleukin-6	TGF-b	3569	7040	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Urinary interleukin-6 -LRB- IL-6 -RRB- and transforming growth factor -LRB- TGF-b -RRB- levels in corticosteroidtreated patients with IgA_nephropathy .
23917204	0	interleukin-6	26,39	TIS21	0,5	interleukin-6	TIS21	3569	7832	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TIS21 -LRB- / BTG2/PC3 -RRB- inhibits interleukin-6 expression via downregulation of STAT3 pathway .
12445803	0	interleukin-6	89,102	TNF-alpha	78,87	interleukin-6	TNF-alpha	3569	7124	Gene	Gene	factor-alpha|amod|START_ENTITY factor-alpha|appos|END_ENTITY	Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha -LRB- TNF-alpha -RRB- interleukin-6 -LRB- IL-6 -RRB- and soluble interleukin-6_receptor -LRB- sIL-6R gp80 -RRB- in multiple_sclerosis patients .
15906094	0	interleukin-6	21,34	TNFR2	86,91	interleukin-6	TNFR2	3569	7133	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association tests of interleukin-6 -LRB- IL-6 -RRB- and type II tumor_necrosis_factor receptor -LRB- TNFR2 -RRB- genes with bone_mineral_density in Caucasians using a re-sampling approach .
11701462	0	interleukin-6	17,30	Thrombin	0,8	interleukin-6	Thrombin	3569	2147	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells .
10212284	0	interleukin-6	41,54	Transforming_growth_factor-beta1	0,32	interleukin-6	Transforming growth factor-beta1	3569	7040	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-beta1 induces interleukin-6 expression via activating_protein-1 consisting of JunD homodimers in primary human lung fibroblasts .
12853969	0	interleukin-6	43,56	Transforming_growth_factor-beta1	0,32	interleukin-6	Transforming growth factor-beta1	3569	7040	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 activates interleukin-6 expression in prostate_cancer cells through the synergistic collaboration of the Smad2 , p38-NF-kappaB , JNK , and Ras signaling pathways .
21457063	0	interleukin-6	26,39	Tristetraprolin	0,15	interleukin-6	Tristetraprolin	16193(Tax:10090)	22695(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tristetraprolin regulates interleukin-6 expression through p38_MAPK-dependent affinity changes with mRNA 3 ' untranslated region .
21656745	0	interleukin-6	26,39	Tristetraprolin	0,15	interleukin-6	Tristetraprolin	3569	7538	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Tristetraprolin regulates interleukin-6 , which is correlated with tumor progression in patients with head_and_neck_squamous_cell_carcinoma .
21153161	0	interleukin-6	32,45	Tumor_necrosis_factor	0,21	interleukin-6	Tumor necrosis factor	24498(Tax:10116)	103694380	Gene	Gene	release|amod|START_ENTITY increases|dobj|release increases|nsubj|END_ENTITY	Tumor_necrosis_factor increases interleukin-6 release from adrenal zona glomerulosa cellsin vitro .
21191629	0	interleukin-6	58,71	Tumor_necrosis_factor-a	0,23	interleukin-6	Tumor necrosis factor-a	3569	7124	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-a induces expression and release of interleukin-6 by human urothelial cells .
10873159	0	interleukin-6	70,83	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	3569	7124	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells enhances|dobj|expression enhances|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha enhances mRNA expression and secretion of interleukin-6 in cultured human airway smooth muscle cells .
12889600	0	interleukin-6	36,49	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	3569	7124	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-6 production via extracellular-regulated kinase 1 activation in breast_cancer cells .
15474068	0	interleukin-6	51,64	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	3569	7124	Gene	Gene	pathways|amod|START_ENTITY release|nmod|pathways induced|dobj|release induced|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induced the release of interleukin-6 from endometriotic stromal cells by the nuclear_factor-kappaB and mitogen-activated protein kinase pathways .
23790133	0	interleukin-6	29,42	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	3569	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-10 levels are altered in preeclampsia : a systematic review and meta-analysis .
9089655	0	interleukin-6	36,49	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	3569	7124	Gene	Gene	mRNA|amod|START_ENTITY induces|dobj|mRNA induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-6 mRNA and protein in human granulosa luteinizing cells via protein_tyrosine_kinase without involving ceramide .
9312119	0	interleukin-6	42,55	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	synthesis|amod|START_ENTITY autoregulates|dobj|synthesis autoregulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha autoregulates interleukin-6 synthesis via activation of protein_kinase_C .
9516459	0	interleukin-6	36,49	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces interleukin-6 production and integrin ligand expression by distinct transduction pathways .
9607836	0	interleukin-6	29,42	Tumor_necrosis_factor-alpha	0,27	interleukin-6	Tumor necrosis factor-alpha	3569	7124	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|appos|secretion	Tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-8 secretion and the acute-phase response in patients with bacterial_and_tuberculous_osteomyelitis .
20178529	0	interleukin-6	29,42	Tumor_necrosis_factor_alpha	0,27	interleukin-6	Tumor necrosis factor alpha	3569	7124	Gene	Gene	polymorphisms|amod|START_ENTITY END_ENTITY|appos|polymorphisms	Tumor_necrosis_factor_alpha , interleukin-6 and interleukin-10 polymorphisms in preeclampsia .
16777977	0	interleukin-6	18,31	Urocortin	0,9	interleukin-6	Urocortin	24498(Tax:10116)	29151(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Urocortin induces interleukin-6 gene expression via cyclooxygenase-2 activity in aortic smooth muscle cells .
19211730	0	interleukin-6	18,31	Urocortin	0,9	interleukin-6	Urocortin	24498(Tax:10116)	29151(Tax:10116)	Gene	Gene	release|amod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase , ERK and NF-kappaB activation .
17525365	0	interleukin-6	76,89	Vascular_endothelial_growth_factor	0,34	interleukin-6	Vascular endothelial growth factor	3569	7422	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Vascular_endothelial_growth_factor is induced by the inflammatory cytokines interleukin-6 and oncostatin_m in human adipose tissue in vitro and in murine adipose tissue in vivo .
15919832	0	interleukin-6	14,27	adiponectin	64,75	interleukin-6	adiponectin	3569	9370	Gene	Gene	promoter|amod|START_ENTITY Effect|nmod|promoter polymorphism|nsubj|Effect polymorphism|nmod|sensitivity sensitivity|compound|END_ENTITY	Effect of the interleukin-6 -LRB- -174 -RRB- g/c promoter polymorphism on adiponectin and insulin sensitivity .
17022850	0	interleukin-6	54,67	adiponectin	41,52	interleukin-6	adiponectin	3569	9370	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Effect of gliclazide modified release on adiponectin , interleukin-6 , and tumor_necrosis_factor-alpha plasma levels in individuals with type_2_diabetes_mellitus .
19885628	0	interleukin-6	30,43	adiponectin	15,26	interleukin-6	adiponectin	3569	9370	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	The effects of adiponectin on interleukin-6 and MCP-1 secretion in lipopolysaccharide-treated 3T3-L1 adipocytes : role of the NF-kappaB pathway .
22549135	0	interleukin-6	68,81	adiponectin	16,27	interleukin-6	adiponectin	3569	9370	Gene	Gene	expression|acl|START_ENTITY Synergy|nmod|expression Synergy|nmod|END_ENTITY	Synergy between adiponectin and interleukin-1b on the expression of interleukin-6 , interleukin-8 , and cyclooxygenase-2 in fibroblast-like synoviocytes .
22614149	0	interleukin-6	74,87	adiponectin	61,72	interleukin-6	adiponectin	3569	9370	Gene	Gene	bouts|amod|START_ENTITY bouts|nmod|END_ENTITY	Effects of repeated bouts of supramaximal exercise on plasma adiponectin , interleukin-6 , and tumor_necrosis_factor-a levels in sedentary men .
21562237	0	interleukin-6	47,60	adipose	87,94	interleukin-6	adipose	16193(Tax:10090)	230796(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stearidonic_and_eicosapentaenoic_acids inhibit interleukin-6 expression in ob/ob mouse adipose stem cells via Toll-like_receptor-2-mediated pathways .
1318656	0	interleukin-6	52,65	adrenocorticotropic_hormone	13,40	interleukin-6	adrenocorticotropic hormone	3569	5443	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Induction Induction|nmod|END_ENTITY	Induction of adrenocorticotropic_hormone release by interleukin-6 in vivo and in vitro .
1282854	0	interleukin-6	82,95	alpha_2-macroglobulin	125,146	interleukin-6	alpha 2-macroglobulin	24498(Tax:10116)	24153(Tax:10116)	Gene	Gene	relationship|nmod|START_ENTITY abscesses|nmod|relationship abscesses|xcomp|END_ENTITY	Effect of aseptic abscesses in protein-deficient rats on the relationship between interleukin-6 and the acute-phase protein , alpha_2-macroglobulin .
2466233	0	interleukin-6	57,70	alpha_2-macroglobulin	103,124	interleukin-6	alpha 2-macroglobulin	24498(Tax:10116)	24153(Tax:10116)	Gene	Gene	dependent|amod|START_ENTITY expression|amod|dependent expression|nmod|gene gene|amod|END_ENTITY	Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha_2-macroglobulin gene .
2479916	0	interleukin-6	36,49	alpha_2-macroglobulin	76,97	interleukin-6	alpha 2-macroglobulin	24498(Tax:10116)	24153(Tax:10116)	Gene	Gene	responsive|amod|START_ENTITY element|amod|responsive element|nmod|gene gene|amod|END_ENTITY	Nuclear factors interacting with an interleukin-6 responsive element of rat alpha_2-macroglobulin gene .
2483766	0	interleukin-6	55,68	alpha_2-macroglobulin	14,35	interleukin-6	alpha 2-macroglobulin	24498(Tax:10116)	24153(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of alpha_2-macroglobulin gene expression by interleukin-6 -LRB- BSF-2 / HSF -RRB- .
11751884	0	interleukin-6	57,70	androgen_receptor	18,35	interleukin-6	androgen receptor	3569	367	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Activation of the androgen_receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways .
10406834	0	interleukin-6	13,26	angiotensin_II	41,55	interleukin-6	angiotensin II	24498(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of interleukin-6 expression by angiotensin_II in rat vascular smooth muscle cells .
12536569	0	interleukin-6	62,75	angiotensin_II	12,26	interleukin-6	angiotensin II	3569	183	Gene	Gene	proliferation|nmod|START_ENTITY END_ENTITY|nmod|proliferation	-LSB- Effects of angiotensin_II on proliferation and expression of interleukin-6 of human kidney fibroblasts -RSB- .
17059008	0	interleukin-6	48,61	angiotensin_II	25,39	interleukin-6	angiotensin II	24498(Tax:10116)	24179(Tax:10116)	Gene	Gene	induced|xcomp|START_ENTITY END_ENTITY|acl|induced	-LSB- Effects of quercetin on angiotensin_II induced interleukin-6 in vascular smooth muscle cells -RSB- .
11222745	0	interleukin-6	129,142	angiotensinogen	105,120	interleukin-6	angiotensinogen	3569	183	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Role of signal transducers and activators of transcription 1 and -3 in inducible regulation of the human angiotensinogen gene by interleukin-6 .
20889504	0	interleukin-6	13,26	bone_morphogenetic_protein-6	41,69	interleukin-6	bone morphogenetic protein-6	3569	654	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of interleukin-6 expression by bone_morphogenetic_protein-6 in macrophages requires both SMAD and p38 signaling pathways .
24140302	0	interleukin-6	71,84	brain-derived_neurotrophic_factor	26,59	interleukin-6	brain-derived neurotrophic factor	3569	627	Gene	Gene	Association|amod|START_ENTITY Association|nmod|END_ENTITY	Association between serum brain-derived_neurotrophic_factor and plasma interleukin-6 in major_depressive_disorder with melancholic_features .
11818252	0	interleukin-6	130,143	c-Myc	63,68	interleukin-6	c-Myc	24498(Tax:10116)	24577(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY rats|dep|role rats|amod|END_ENTITY	Ductular_hyperplasia is characterized by an over expression of c-Myc in bile duct ligation + furan injured rats : possible role of interleukin-6 .
9108382	0	interleukin-6	34,47	c-kit	52,57	interleukin-6	c-kit	16193(Tax:10090)	16590(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Differential release of mast cell interleukin-6 via c-kit .
1588953	0	interleukin-6	27,40	c-myc	113,118	interleukin-6	c-myc	3569	4609	Gene	Gene	disrupts|amod|START_ENTITY myeloid|nsubj|disrupts myeloid|dobj|differentiation differentiation|advmod|prior prior|advcl|END_ENTITY	Deregulated c-myb disrupts interleukin-6 - or leukemia_inhibitory_factor-induced myeloid differentiation prior to c-myc : role in leukemogenesis .
10233692	0	interleukin-6	133,146	calcitonin_gene-related_peptide	71,102	interleukin-6	calcitonin gene-related peptide	16193(Tax:10090)	12310(Tax:10090)	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	Role of nitric_oxide and prostaglandins in the potentiating effects of calcitonin_gene-related_peptide on lipopolysaccharide-induced interleukin-6 release from mouse peritoneal macrophages .
18461289	0	interleukin-6	6,19	cystatin_C	79,89	interleukin-6	cystatin C	3569	1471	Gene	Gene	correlation|dep|START_ENTITY correlation|nmod|END_ENTITY	Serum interleukin-6 in patients with metastatic bone_disease : correlation with cystatin_C .
24709011	0	interleukin-6	64,77	doxorubicin_resistance	37,59	interleukin-6	doxorubicin resistance	3569	5243	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	TLR5 activation by flagellin induces doxorubicin_resistance via interleukin-6 -LRB- IL-6 -RRB- expression in two multiple myeloma cells .
12390846	0	interleukin-6	37,50	endostatin	23,33	interleukin-6	endostatin	3569	80781	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	-LSB- Inhibitory effects of endostatin on interleukin-6 and interleukin-8 release by human umbilical vein endothelial cells -RSB- .
16527283	0	interleukin-6	53,66	endothelin-1	78,90	interleukin-6	endothelin-1	3569	1906	Gene	Gene	Vitamin_C_blocks_vascular_dysfunction|nmod|START_ENTITY induced|nsubj|Vitamin_C_blocks_vascular_dysfunction induced|nmod|END_ENTITY	Vitamin_C_blocks_vascular_dysfunction and release of interleukin-6 induced by endothelin-1 in humans in vivo .
19389001	0	interleukin-6	48,61	endothelin-1	14,26	interleukin-6	endothelin-1	3569	1906	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	The effect of endothelin-1 on the production of interleukin-6 in cultured human detrusor smooth muscle cells , and the effect of interleukin-6 on the contractile response of bladder smooth muscle strips from rats .
22290536	0	interleukin-6	25,38	endothelin-1	53,65	interleukin-6	endothelin-1	16193(Tax:10090)	13614(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|nmod|END_ENTITY	Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic_AMP in adipocytes .
19143943	0	interleukin-6	43,56	epidermal_growth_factor	18,41	interleukin-6	epidermal growth factor	3569	1950	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Urinary levels of epidermal_growth_factor , interleukin-6 and monocyte_chemoattractant_protein-1 may act as predictor markers of renal function outcome in immunoglobulin A nephropathy .
7651415	0	interleukin-6	18,31	estrogen_receptor	44,61	interleukin-6	estrogen receptor	3569	2099	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Repression of the interleukin-6 promoter by estrogen_receptor is mediated by NF-kappa_B and C/EBP _ beta .
15515781	0	interleukin-6	10,23	familial_Mediterranean_fever	68,96	interleukin-6	familial Mediterranean fever	3569	4210	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	Levels of interleukin-6 -LRB- IL-6 -RRB- and its soluble receptor -LRB- sIL-6R -RRB- in familial_Mediterranean_fever -LRB- FMF -RRB- patients and their first degree relatives .
11224491	0	interleukin-6	69,82	fibrinogen	86,96	interleukin-6	fibrinogen	3569	2244	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	The effect of the interleukin-6 c/g -174 polymorphism and circulating interleukin-6 on fibrinogen plasma levels .
9879291	0	interleukin-6	15,28	fibrinogen	56,66	interleukin-6	fibrinogen	3569	2244	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Involvement of interleukin-6 in the elevation of plasma fibrinogen levels in lung_cancer patients .
10229675	0	interleukin-6	14,27	fibroblast_growth_factor-2	71,97	interleukin-6	fibroblast growth factor-2	3569	2247	Gene	Gene	activity|amod|START_ENTITY Inhibition|nmod|activity Inhibition|nmod|cells cells|amod|END_ENTITY	Inhibition of interleukin-6 promoter activity by the 24 kDa isoform of fibroblast_growth_factor-2 in HeLa cells .
11102571	0	interleukin-6	14,27	fibroblast_growth_factor-2	112,138	interleukin-6	fibroblast growth factor-2	24498(Tax:10116)	54250(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|relation relation|nmod|END_ENTITY	Expression of interleukin-6 and its receptor in the sciatic nerve and cultured Schwann cells : relation to 18-kD fibroblast_growth_factor-2 .
10427501	0	interleukin-6	75,88	gp130	18,23	interleukin-6	gp130	3569	3572	Gene	Gene	complex|amod|START_ENTITY formation|nmod|complex critical|nmod|formation critical|nsubj|N-terminus N-terminus|nmod|END_ENTITY	The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex .
10482577	0	interleukin-6	20,33	gp130	58,63	interleukin-6	gp130	4961449(Tax:37296)	3572	Gene	Gene	signals|nsubj|START_ENTITY signals|nmod|END_ENTITY	Human_herpesvirus_8 interleukin-6 -LRB- vIL-6 -RRB- signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6 .
10692570	0	interleukin-6	56,69	gp130	36,41	interleukin-6	gp130	3569	3572	Gene	Gene	required|nmod|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	Different epitopes are required for gp130 activation by interleukin-6 , oncostatin_M and leukemia_inhibitory_factor .
10720531	0	interleukin-6	50,63	gp130	94,99	interleukin-6	gp130	3569	3572	Gene	Gene	receptors|amod|START_ENTITY down-regulates|dobj|receptors down-regulates|advcl|influencing influencing|dobj|expression expression|amod|END_ENTITY	Endotoxin down-regulates monocyte and granulocyte interleukin-6 receptors without influencing gp130 expression in humans .
10777583	0	interleukin-6	40,53	gp130	111,116	interleukin-6	gp130	3569	3572	Gene	Gene	transduction|amod|START_ENTITY function|nmod|transduction exerts|dobj|function exerts|nmod|site site|nmod|END_ENTITY	SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130 .
10843753	0	interleukin-6	14,27	gp130	35,40	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|signalling signalling|amod|END_ENTITY	The effect of interleukin-6 -LRB- IL-6 -RRB- / gp130 signalling on biliary epithelial cell growth , in vitro .
10848977	0	interleukin-6	21,34	gp130	54,59	interleukin-6	gp130	3569	3572	Gene	Gene	homologue|dep|START_ENTITY homologue|dobj|END_ENTITY	Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells .
11121117	0	interleukin-6	50,63	gp130	8,13	interleukin-6	gp130	3569	3572	Gene	Gene	responses|amod|START_ENTITY inhibitor|nmod|responses inhibitor|nsubj|END_ENTITY	Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses .
11473581	0	interleukin-6	84,97	gp130	64,69	interleukin-6	gp130	3569	3572	Gene	Gene	signalling|amod|START_ENTITY END_ENTITY|nmod|signalling	Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling .
11884403	0	interleukin-6	16,29	gp130	94,99	interleukin-6	gp130	3569	3572	Gene	Gene	receptor|amod|START_ENTITY Shedding|nmod|receptor determines|nsubj|Shedding determines|xcomp|induce induce|dobj|phosphorylation phosphorylation|amod|END_ENTITY	Shedding of the interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- gp80 -RRB- determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts .
12403768	0	interleukin-6	62,75	gp130	94,99	interleukin-6	gp130	3569	3572	Gene	Gene	signaling|amod|START_ENTITY attenuation|nmod|signaling Tyr-759-dependent|dobj|attenuation Tyr-759-dependent|nmod|END_ENTITY	SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130 .
12630694	0	interleukin-6	33,46	gp130	47,52	interleukin-6	gp130	3569	3572	Gene	Gene	START_ENTITY|dep|interaction interaction|amod|END_ENTITY	Synthetic peptides mimicking the interleukin-6 / gp130 interaction : a two-helix bundle system .
12646580	0	interleukin-6	94,107	gp130	24,29	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY acts|nmod|inhibitor acts|nsubj|protein protein|nmod|END_ENTITY	A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor .
1433971	0	interleukin-6	5,18	gp130	38,43	interleukin-6	gp130	3569	3572	Gene	Gene	transducer|amod|START_ENTITY -LSB-|dobj|transducer -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The interleukin-6 signal transducer , gp130 , functioning in immune , hematopoietic , and neural systems -RSB- .
14672670	0	interleukin-6	89,102	gp130	74,79	interleukin-6	gp130	4961449(Tax:37296)	3572	Gene	Gene	HHV-8|nummod|START_ENTITY END_ENTITY|nmod|HHV-8	Molecular mechanisms for viral mimicry of a human cytokine : activation of gp130 by HHV-8 interleukin-6 .
1544406	0	interleukin-6	73,86	gp130	63,68	interleukin-6	gp130	3569	3572	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of the interleukin-6-signal transducing protein -LRB- gp130 -RRB- by interleukin-6 and dexamethasone in HepG2 cells .
16274960	0	interleukin-6	84,97	gp130	116,121	interleukin-6	gp130	403985(Tax:9615)	403545(Tax:9615)	Gene	Gene	signal|amod|START_ENTITY domain|nmod|signal signal|nmod|domain Identification|nmod|signal transducer|nsubj|Identification transducer|dobj|END_ENTITY	Identification of a basolateral sorting signal within the cytoplasmic domain of the interleukin-6 signal transducer gp130 .
16367943	0	interleukin-6	22,35	gp130	63,68	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY circulating|dobj|receptor form|acl|circulating component|nsubj|form component|dobj|END_ENTITY	A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory_bowel_disease .
16367943	0	interleukin-6	84,97	gp130	63,68	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY component|nmod|inhibitor component|dobj|END_ENTITY	A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory_bowel_disease .
17058237	0	interleukin-6	19,32	gp130	47,52	interleukin-6	gp130	24498(Tax:10116)	25205(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|receptor-dependent receptor-dependent|amod|END_ENTITY	Bile_acids inhibit interleukin-6 signaling via gp130 receptor-dependent and - independent pathways in rat liver .
18373551	0	interleukin-6	55,68	gp130	26,31	interleukin-6	gp130	3569	3572	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction .
19264784	0	interleukin-6	17,30	gp130	42,47	interleukin-6	gp130	3569	3572	Gene	Gene	binding|amod|START_ENTITY Unraveling|dobj|binding Unraveling|nmod|END_ENTITY	Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6_receptor .
20660911	0	interleukin-6	25,38	gp130	8,13	interleukin-6	gp130	3569	3572	Gene	Gene	regulatess|xcomp|START_ENTITY regulatess|nsubj|END_ENTITY	Soluble gp130 regulatess interleukin-6 in cerebrospinal fluid after subarachnoid_haemorrhage .
21035897	0	interleukin-6	60,73	gp130	92,97	interleukin-6	gp130	3569	3572	Gene	Gene	signal|amod|START_ENTITY domain|nmod|signal structure|nmod|domain transducer|nsubj|structure transducer|dobj|END_ENTITY	The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution .
21944124	0	interleukin-6	71,84	gp130	8,13	interleukin-6	gp130	3569	3572	Gene	Gene	manner|amod|START_ENTITY invasion|nmod|manner regulates|dobj|invasion regulates|nsubj|END_ENTITY	Soluble gp130 regulates prostate_cancer invasion and progression in an interleukin-6 dependent and independent manner .
24504821	0	interleukin-6	80,93	gp130	55,60	interleukin-6	gp130	3569	3572	Gene	Gene	signaling|dep|START_ENTITY signaling|nsubj|impairs impairs|amod|END_ENTITY	The p38-mediated rapid down-regulation of cell surface gp130 expression impairs interleukin-6 signaling in the synovial fluid of juvenile_idiopathic_arthritis patients .
25078695	0	interleukin-6	26,39	gp130	58,63	interleukin-6	gp130	3569	3572	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Human_herpesvirus_8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion_lymphoma and endothelial cells .
26809098	0	interleukin-6	22,35	gp130	61,66	interleukin-6	gp130	3569	3572	Gene	Gene	family|amod|START_ENTITY form|nmod|family signal|nsubj|form signal|ccomp|dimerized dimerized|nsubjpass|END_ENTITY	A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing .
7530500	0	interleukin-6	96,109	gp130	62,67	interleukin-6	gp130	3569	3572	Gene	Gene	family|amod|START_ENTITY transducer|nmod|family END_ENTITY|appos|transducer	Association and activation of Btk and Tec tyrosine kinases by gp130 , a signal transducer of the interleukin-6 family of cytokines .
7713920	0	interleukin-6	33,46	gp130	59,64	interleukin-6	gp130	3569	3572	Gene	Gene	mutations|nmod|START_ENTITY Combining|dobj|mutations affect|dep|Combining affect|dobj|results results|amod|END_ENTITY	Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6_receptor antagonist on human myeloma cells .
7734154	0	interleukin-6	91,104	gp130	43,48	interleukin-6	gp130	3569	3572	Gene	Gene	cytokines|amod|START_ENTITY specific|nmod|cytokines present|nmod|specific present|nsubj|regulation regulation|nmod|protein protein|appos|END_ENTITY	Separate regulation of a membrane protein , gp130 , present in receptor complex specific for interleukin-6 and other functionally related cytokines .
8157624	0	interleukin-6	52,65	gp130	103,108	interleukin-6	gp130	3569	3572	Gene	Gene	antagonist|amod|START_ENTITY behaves|nmod|antagonist behaves|ccomp|expressing expressing|dobj|END_ENTITY	Oncostatin_M binds directly to gp130 and behaves as interleukin-6 antagonist on a cell line expressing gp130 but lacking functional oncostatin_M receptors .
8353278	0	interleukin-6	21,34	gp130	162,167	interleukin-6	gp130	3569	3572	Gene	Gene	gp130|amod|START_ENTITY forms|nmod|gp130 signals|nsubj|forms signals|nmod|END_ENTITY	Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130 .
8662709	0	interleukin-6	65,78	gp130	0,5	interleukin-6	gp130	3569	3572	Gene	Gene	responses|amod|START_ENTITY induce|dobj|responses sufficient|xcomp|induce sufficient|nsubj|cross-linking cross-linking|amod|END_ENTITY	gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses .
9073325	0	interleukin-6	41,54	gp130	22,27	interleukin-6	gp130	3569	3572	Gene	Gene	family|amod|START_ENTITY shared|nmod|family shared|nsubjpass|END_ENTITY	The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines .
9295319	0	interleukin-6	125,138	gp130	67,72	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	IL-6|amod|START_ENTITY sites|nmod|IL-6 identification|nmod|sites leads|nmod|identification leads|nsubj|mutagenesis mutagenesis|nmod|part part|nmod|END_ENTITY	Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 -LRB- IL-6 -RRB- .
9558387	0	interleukin-6	118,131	gp130	0,5	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	downregulated|advcl|START_ENTITY downregulated|nsubjpass|END_ENTITY	gp130 , the cytokine common signal-transducer of interleukin-6 cytokine family , is downregulated in T cells in vivo by interleukin-6 .
9558387	0	interleukin-6	48,61	gp130	0,5	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	family|amod|START_ENTITY signal-transducer|nmod|family END_ENTITY|appos|signal-transducer	gp130 , the cytokine common signal-transducer of interleukin-6 cytokine family , is downregulated in T cells in vivo by interleukin-6 .
9616171	0	interleukin-6	8,21	gp130	2,7	interleukin-6	gp130	16193(Tax:10090)	16195(Tax:10090)	Gene	Gene	transducer-dependent|amod|START_ENTITY transducer-dependent|amod|END_ENTITY	A gp130 interleukin-6 transducer-dependent SCID model of human multiple_myeloma .
9712900	0	interleukin-6	69,82	gp130	34,39	interleukin-6	gp130	3569	3572	Gene	Gene	signaling|nmod|START_ENTITY required|advcl|signaling required|nsubjpass|module module|nmod|END_ENTITY	The immunoglobulin-like module of gp130 is required for signaling by interleukin-6 , but not by leukemia_inhibitory_factor .
9794795	0	interleukin-6	60,73	gp130	110,115	interleukin-6	gp130	3569	3572	Gene	Gene	signal|amod|START_ENTITY signal|acl|transducing transducing|dobj|END_ENTITY	Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression .
9883890	0	interleukin-6	75,88	gp130	107,112	interleukin-6	gp130	3569	3572	Gene	Gene	signal|amod|START_ENTITY protein-2|nmod|signal END_ENTITY|amod|protein-2	Constitutive internalization and association with adaptor protein-2 of the interleukin-6 signal transducer gp130 .
8641372	0	interleukin-6	150,163	granulocyte-macrophage_colony-stimulating_factor	14,62	interleukin-6	granulocyte-macrophage colony-stimulating factor	3569	1437	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|receptors receptors|amod|END_ENTITY	Regulation of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- receptors in a GM-CSF-dependent human myeloid_leukemia cell line -LRB- AML-193 -RRB- by interleukin-6 .
7582261	0	interleukin-6	19,32	granulocyte_colony-stimulating_factor	61,98	interleukin-6	granulocyte colony-stimulating factor	3569	1440	Gene	Gene	levels|amod|START_ENTITY Elevation|nmod|levels Elevation|nmod|level level|amod|END_ENTITY	Elevation of serum interleukin-6 levels before peak of serum granulocyte_colony-stimulating_factor level in chemotherapy-induced myelosuppressive patients .
8555479	0	interleukin-6	126,139	granulocyte_colony-stimulating_factor	15,52	interleukin-6	granulocyte colony-stimulating factor	3569	1440	Gene	Gene	secretion|nmod|START_ENTITY induce|dobj|secretion mobilized|ccomp|induce cells|acl|mobilized cells|nmod|END_ENTITY	CD14 + cells in granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- - mobilized peripheral blood mononuclear cells induce secretion of interleukin-6 and G-CSF by marrow_stroma .
11061508	0	interleukin-6	42,55	growth_hormone	57,71	interleukin-6	growth hormone	3569	2688	Gene	Gene	cortisol|amod|START_ENTITY cortisol|amod|END_ENTITY	Effects of sleep_and_sleep_deprivation on interleukin-6 , growth_hormone , cortisol , and melatonin levels in humans .
16807770	0	interleukin-6	17,30	growth_hormone	41,55	interleukin-6	growth hormone	3569	2688	Gene	Gene	Co-expression|nmod|START_ENTITY END_ENTITY|nsubj|Co-expression	Co-expression of interleukin-6 and human growth_hormone in apparently normal prostate biopsies that ultimately progress to prostate_cancer using low pH , high temperature antigen retrieval .
18074473	0	interleukin-6	41,54	growth_hormone	13,27	interleukin-6	growth hormone	3569	2688	Gene	Gene	requiem|nmod|START_ENTITY Overture|dep|requiem Overture|nmod|END_ENTITY	Overture for growth_hormone : requiem for interleukin-6 ?
18686625	0	interleukin-6	76,89	growth_hormone	99,113	interleukin-6	growth hormone	3569	2688	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth_hormone gene expression in rat MtT/S somatotroph cells .
16453892	0	interleukin-6	118,131	haptoglobin	10,21	interleukin-6	haptoglobin	3569	3240	Gene	Gene	induced|advcl|START_ENTITY protein|acl|induced interact|nmod|protein elements|acl|interact promoter|dep|elements promoter|compound|END_ENTITY	The human haptoglobin gene promoter : interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6 .
2320005	0	interleukin-6	58,71	haptoglobin	121,132	interleukin-6	haptoglobin	24498(Tax:10116)	24464(Tax:10116)	Gene	Gene	element|amod|START_ENTITY element|nmod|gene gene|compound|END_ENTITY	Structure , hormonal regulation , and identification of the interleukin-6 - and dexamethasone-responsive element of the rat haptoglobin gene .
23701120	0	interleukin-6	107,120	haptoglobin	29,40	interleukin-6	haptoglobin	3569	3240	Gene	Gene	expression|amod|START_ENTITY C-terminal|nmod|expression C-terminal|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a specific haptoglobin C-terminal fragment in arthritic synovial fluid and its effect on interleukin-6 expression .
2787245	0	interleukin-6	118,131	haptoglobin	10,21	interleukin-6	haptoglobin	3569	3240	Gene	Gene	induced|advcl|START_ENTITY protein|acl|induced interact|nmod|protein elements|acl|interact promoter|dep|elements promoter|compound|END_ENTITY	The human haptoglobin gene promoter : interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6 .
7492636	0	interleukin-6	40,53	haptoglobin	15,26	interleukin-6	haptoglobin	280826(Tax:9913)	280692(Tax:9913)	Gene	Gene	synthesis|nmod|START_ENTITY Stimulation|amod|synthesis Stimulation|nmod|END_ENTITY	Stimulation of haptoglobin synthesis by interleukin-6 and tumor_necrosis_factor , but not by interleukin-1 , in bovine primary cultured hepatocytes .
7586584	0	interleukin-6	125,138	haptoglobin	45,56	interleukin-6	haptoglobin	3569	3240	Gene	Gene	relationships|nmod|START_ENTITY Components|dep|relationships Components|nmod|variation variation|nmod|END_ENTITY	Components of biological variation in plasma haptoglobin : relationships to plasma fibrinogen and immune variables , including interleukin-6 and its receptor .
8387722	0	interleukin-6	154,167	haptoglobin	62,73	interleukin-6	haptoglobin	3569	3240	Gene	Gene	cells|amod|START_ENTITY decreases|nmod|cells decreases|nsubj|substitution substitution|nmod|promoter promoter|acl|associated associated|nmod|phenotype phenotype|amod|END_ENTITY	A base substitution in the promoter associated with the human haptoglobin 2-1 modified phenotype decreases transcriptional activity and responsiveness to interleukin-6 in human hepatoma cells .
15640832	0	interleukin-6	103,116	heme_oxygenase-1	16,32	interleukin-6	heme oxygenase-1	24498(Tax:10116)	24451(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY inflammation|dep|involvement oil-induced|dobj|inflammation oil-induced|nsubj|Upregulation Upregulation|nmod|gene gene|amod|END_ENTITY	Upregulation of heme_oxygenase-1 gene by turpentine oil-induced localized inflammation : involvement of interleukin-6 .
16510205	0	interleukin-6	49,62	heme_oxygenase-1	18,34	interleukin-6	Heme oxygenase-1	24498(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of rat heme_oxygenase-1 expression by interleukin-6 via the Jak/STAT pathway in hepatocytes .
18547752	0	interleukin-6	72,85	heme_oxygenase-1	25,41	interleukin-6	heme oxygenase-1	24498(Tax:10116)	24451(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Up-regulation of hepatic heme_oxygenase-1 expression by locally induced interleukin-6 in rats administered carbon_tetrachloride intraperitoneally .
11322204	0	interleukin-6	74,87	hepatocyte_growth_factor	18,42	interleukin-6	hepatocyte growth factor	3569	3082	Gene	Gene	proteins|amod|START_ENTITY treated|nsubj|proteins treated|nsubj|response response|nmod|END_ENTITY	Serum response of hepatocyte_growth_factor , insulin-like_growth_factor-I , interleukin-6 , and acute phase proteins in patients with colorectal_liver_metastases treated with partial hepatectomy or cryosurgery .
11424323	0	interleukin-6	18,31	hepatocyte_growth_factor	40,64	interleukin-6	hepatocyte growth factor	3569	3082	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|compound|END_ENTITY	Recombinant human interleukin-6 induces hepatocyte_growth_factor production in cancer patients .
12174163	0	interleukin-6	15,28	hepatocyte_growth_factor	48,72	interleukin-6	hepatocyte growth factor	3569	3082	Gene	Gene	Association|acl|START_ENTITY Association|nmod|END_ENTITY	Association of interleukin-6 and estradiol with hepatocyte_growth_factor in peritoneal fluid of women with endometriosis .
19114373	0	interleukin-6	69,82	high_mobility_group_Box-1	27,52	interleukin-6	high mobility group Box-1	3569	3146	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	-LSB- Effect of progesterone on high_mobility_group_Box-1 protein-induced interleukin-6 release by human umbilic vein endothelial cells -RSB- .
15845578	0	interleukin-6	57,70	iNOS	84,88	interleukin-6	iNOS	3569	4843	Gene	Gene	exposure|amod|START_ENTITY exposure|nmod|END_ENTITY	Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via iNOS in adult ventricular myocytes .
15242694	0	interleukin-6	30,43	insulin	63,70	interleukin-6	insulin	3569	3630	Gene	Gene	correlate|amod|START_ENTITY correlate|compound|END_ENTITY	Tumour necrosis factor-alpha , interleukin-6 , and fasting serum insulin correlate with clinical outcome in metastatic breast_cancer patients treated with chemotherapy .
16043746	0	interleukin-6	43,56	insulin	81,88	interleukin-6	insulin	3569	3630	Gene	Gene	gene|amod|START_ENTITY promoter|nmod|gene polymorphism|nmod|promoter associated|nsubjpass|polymorphism associated|nmod|resistance resistance|compound|END_ENTITY	C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance .
16804071	0	interleukin-6	7,20	insulin	62,69	interleukin-6	insulin	3569	3630	Gene	Gene	levels|amod|START_ENTITY associated|nsubjpass|levels associated|nmod|secretion secretion|compound|END_ENTITY	Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects .
16984279	0	interleukin-6	12,25	insulin	66,73	interleukin-6	insulin	3569	3630	Gene	Gene	arterial_injury|amod|START_ENTITY Increase|nmod|arterial_injury related|nsubjpass|Increase related|nmod|resistance resistance|compound|END_ENTITY	Increase in interleukin-6 following arterial_injury is related to insulin resistance , the -174 G -- > C polymorphism and complex plaque morphology .
17392554	0	interleukin-6	6,19	insulin	92,99	interleukin-6	insulin	3569	3630	Gene	Gene	correlates|amod|START_ENTITY Serum|dobj|correlates Serum|nmod|endothelial_dysfunction endothelial_dysfunction|nmod|men men|nmod|sensitivity sensitivity|compound|END_ENTITY	Serum interleukin-6 correlates with endothelial_dysfunction in healthy men independently of insulin sensitivity .
17584642	0	interleukin-6	22,35	insulin	88,95	interleukin-6	insulin	3569	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	-LSB- Association of serum interleukin-6 and high-sensitivity C-reactive protein levels with insulin resistance in gestational_diabetes_mellitus -RSB- .
17956545	0	interleukin-6	12,25	insulin	29,36	interleukin-6	insulin	3569	3630	Gene	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	The role of interleukin-6 in insulin resistance , body fat distribution and energy balance .
20731126	0	interleukin-6	14,27	insulin	47,54	interleukin-6	insulin	3569	3630	Gene	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	-LSB- Dual role of interleukin-6 for development of insulin resistance -RSB- .
24063815	0	interleukin-6	84,97	insulin	44,51	interleukin-6	insulin	16193(Tax:10090)	3630	Gene	Gene	delivery|nmod|START_ENTITY sensitivity|nmod|delivery sensitivity|nsubj|improvement improvement|nmod|END_ENTITY	Expression profile-dependent improvement of insulin sensitivity by gene delivery of interleukin-6 in a mouse model of type_II_diabetes .
15195991	0	interleukin-6	133,146	insulin-like_growth_factor-I	16,44	interleukin-6	insulin-like growth factor-I	3569	3479	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of insulin-like_growth_factor-I -LRB- IGF-I -RRB- and dehydroepiandrosterone_sulfate -LRB- DHEA-S -RRB- , and their relationships with serum interleukin-6 , in the geriatric syndrome of frailty .
10872602	0	interleukin-6	27,40	intercellular_adhesion_molecule-1	71,104	interleukin-6	intercellular adhesion molecule-1	3569	3383	Gene	Gene	role|nmod|START_ENTITY role|amod|END_ENTITY	The role of amniotic fluid interleukin-6 , and cell adhesion molecules , intercellular_adhesion_molecule-1 and leukocyte_adhesion_molecule-1 , in intra-amniotic_infection .
7914891	0	interleukin-6	71,84	intercellular_adhesion_molecule-1	25,58	interleukin-6	intercellular adhesion molecule-1	3569	3383	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Stimulation of the human intercellular_adhesion_molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element .
2120129	0	interleukin-6	65,78	interferon-gamma	23,39	interleukin-6	interferon-gamma	3569	3458	Gene	Gene	activity|amod|START_ENTITY effects|nmod|activity effects|nmod|END_ENTITY	Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes .
9516152	0	interleukin-6	30,43	interferon_gamma	97,113	interleukin-6	interferon gamma	3569	3458	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Intracellular localization of interleukin-6 in eosinophils from atopic_asthmatics and effects of interferon_gamma .
10408981	0	interleukin-6	92,105	interleukin-1	37,50	interleukin-6	interleukin-1	3569	3552	Gene	Gene	antagonist|amod|START_ENTITY levels|nmod|antagonist release|nmod|levels stimulates|dobj|release stimulates|nsubj|injection injection|nmod|END_ENTITY	Intracerebroventricular injection of interleukin-1 stimulates the release of high levels of interleukin-6 and interleukin-1 receptor antagonist into peripheral blood in the primate .
1370441	0	interleukin-6	41,54	interleukin-1	70,83	interleukin-6	interleukin-1	3569	3552	Gene	Gene	secrete|xcomp|START_ENTITY secrete|nmod|END_ENTITY	Retinal pigment epithelial cells secrete interleukin-6 in response to interleukin-1 .
1417523	0	interleukin-6	32,45	interleukin-1	15,28	interleukin-6	interleukin-1	3569	3552	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Stimulation by interleukin-1 of interleukin-6 production by human periodontal ligament cells .
15304279	0	interleukin-6	79,92	interleukin-1	44,57	interleukin-6	interleukin-1	3569	3552	Gene	Gene	secretion|nmod|START_ENTITY induced|dobj|secretion induced|nsubj|END_ENTITY	Interleukin-4 and interleukin-13 potentiate interleukin-1 induced secretion of interleukin-6 in human osteoblast-like cells .
1932373	0	interleukin-6	19,32	interleukin-1	53,66	interleukin-6	interleukin-1	3569	3552	Gene	Gene	induces|xcomp|START_ENTITY induces|advcl|END_ENTITY	Bradykinin induces interleukin-6 and synergizes with interleukin-1 .
2103309	0	interleukin-6	79,92	interleukin-1	56,69	interleukin-6	interleukin-1	3569	3552	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|Pretreatment Pretreatment|nmod|smooth_muscle_cells smooth_muscle_cells|nmod|END_ENTITY	Pretreatment of human vascular smooth_muscle_cells with interleukin-1 enhances interleukin-6 production and cell proliferation -LRB- action of IL-1 on vascular smooth_muscle_cells -RRB- .
2242066	0	interleukin-6	22,35	interleukin-1	96,109	interleukin-6	interleukin-1	3569	3552	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Interleukin-1-induced interleukin-6 is required for the inhibition of proteoglycan synthesis by interleukin-1 in human articular cartilage .
7745050	0	interleukin-6	39,52	interleukin-1	24,37	interleukin-6	interleukin-1	3569	3552	Gene	Gene	transforming_growth_factor-beta|dep|START_ENTITY transforming_growth_factor-beta|compound|END_ENTITY	Detection of cytokines -LRB- interleukin-1 , interleukin-6 , transforming_growth_factor-beta -RRB- and soluble tumour_necrosis_factor receptors in embryo culture fluids during in-vitro fertilization .
8634432	0	interleukin-6	119,132	interleukin-1	198,211	interleukin-6	interleukin-1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY potentiate|dobj|induction potentiate|advcl|END_ENTITY	Six different cytokines that share GP130 as a receptor subunit , induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal_axis by interleukin-1 .
9729338	0	interleukin-6	13,26	interleukin-1	76,89	interleukin-6	interleukin-1	3569	3552	Gene	Gene	Formation|nmod|START_ENTITY Formation|dep|relationship relationship|nmod|END_ENTITY	Formation of interleukin-6 in the brain of the febrile cat : relationship to interleukin-1 .
10210768	0	interleukin-6	12,25	interleukin-10	27,41	interleukin-6	interleukin-10	3569	3586	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Analysis of interleukin-6 , interleukin-10 and leukemia_inhibitory_factor -LRB- LIF -RRB- production by peripheral blood cells from patients with systemic_lupus_erythematosus identifies LIF as a potential marker of disease activity .
11022130	0	interleukin-6	61,74	interleukin-10	33,47	interleukin-6	interleukin-10	3569	3586	Gene	Gene	cytokines|amod|START_ENTITY IL-10|nmod|cytokines IL-10|amod|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11847480	0	interleukin-6	87,100	interleukin-10	26,40	interleukin-6	interleukin-10	16193(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY contribute|nmod|expression contribute|nsubj|decline decline|nmod|END_ENTITY	An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice .
17305878	0	interleukin-6	18,31	interleukin-10	32,46	interleukin-6	interleukin-10	3569	3586	Gene	Gene	modulates|amod|START_ENTITY modulates|dep|END_ENTITY	Smoking modulates interleukin-6 : interleukin-10 and RANKL : osteoprotegerin ratios in the periodontal tissues .
22931953	0	interleukin-6	39,52	interleukin-10	54,68	interleukin-6	interleukin-10	3569	3586	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	Identification and predictive value of interleukin-6 + interleukin-10 + and interleukin-6 - interleukin-10 + cytokine patterns in ST-elevation_acute_myocardial_infarction .
22931953	0	interleukin-6	39,52	interleukin-10	89,103	interleukin-6	interleukin-10	3569	3586	Gene	Gene	+|amod|START_ENTITY value|nmod|+ value|dep|patterns patterns|amod|END_ENTITY	Identification and predictive value of interleukin-6 + interleukin-10 + and interleukin-6 - interleukin-10 + cytokine patterns in ST-elevation_acute_myocardial_infarction .
23397947	0	interleukin-6	46,59	interleukin-10	61,75	interleukin-6	interleukin-10	3569	3586	Gene	Gene	monocyte_chemoattractant_protein-1|amod|START_ENTITY monocyte_chemoattractant_protein-1|amod|END_ENTITY	Nicotinamide downregulates gene expression of interleukin-6 , interleukin-10 , monocyte_chemoattractant_protein-1 , and tumour_necrosis_factor-a gene expression in HaCaT keratinocytes after ultraviolet B irradiation .
8686529	0	interleukin-6	12,25	interleukin-10	80,94	interleukin-6	interleukin-10	3569	3586	Gene	Gene	levels|amod|START_ENTITY Increase|nmod|levels Increase|dep|influence influence|nmod|END_ENTITY	Increase of interleukin-6 plasma levels after elective craniotomy : influence of interleukin-10 and catecholamines .
19121317	0	interleukin-6	4,17	interleukin-11	34,48	interleukin-6	interleukin-11	16193(Tax:10090)	16156(Tax:10090)	Gene	Gene	family|amod|START_ENTITY family|amod|END_ENTITY	The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric_tumor development .
18434191	0	interleukin-6	56,69	interleukin-1_alpha	24,43	interleukin-6	interleukin-1 alpha	3569	3552	Gene	Gene	synthesis|amod|START_ENTITY effects|nmod|synthesis effects|nmod|END_ENTITY	Differential effects of interleukin-1_alpha and beta on interleukin-6 and chemokine synthesis in neurones .
9496264	0	interleukin-6	45,58	interleukin-1_and_dexamethasone	10,41	interleukin-6	interleukin-1 and dexamethasone	3569	3552	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of interleukin-1_and_dexamethasone on interleukin-6 production and growth in human meningiomas .
16474945	0	interleukin-6	31,44	interleukin-1_beta	11,29	interleukin-6	interleukin-1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	fields|amod|START_ENTITY fields|amod|END_ENTITY	Effects of interleukin-1_beta , interleukin-6 , and tumor_necrosis_factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats .
8307455	0	interleukin-6	23,36	interleukin-1_beta	38,56	interleukin-6	interleukin-1 beta	3569	3553	Gene	Gene	C-reactive_protein|amod|START_ENTITY C-reactive_protein|amod|END_ENTITY	Interrelations between interleukin-6 , interleukin-1_beta , plasma C-reactive_protein values , and in vitro C-reactive_protein generation in patients with inflammatory_bowel_disease .
8841895	0	interleukin-6	56,69	interleukin-1_beta	29,47	interleukin-6	interleukin-1 beta	3569	3553	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Prostaglandin_E2 potentiates interleukin-1_beta induced interleukin-6 production by human_gingival_fibroblasts .
9369827	0	interleukin-6	26,39	interleukin-1_beta	70,88	interleukin-6	interleukin-1 beta	3569	3553	Gene	Gene	tumor_necrosis_factor-alpha|nummod|START_ENTITY tumor_necrosis_factor-alpha|nummod|END_ENTITY	Amniotic fluid cytokines -LRB- interleukin-6 , tumor_necrosis_factor-alpha , interleukin-1_beta , and interleukin-8 -RRB- and the risk for the development of bronchopulmonary_dysplasia .
24126972	0	interleukin-6	116,129	interleukin-1b	100,114	interleukin-6	interleukin-1b	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effects of Modified Sanhuang Decoction -LRB- -RRB- enema on serum tumor necrosis factor-a and colonic mucosa interleukin-1b , interleukin-6 levels in ulcerative_colitis rats .
10391095	0	interleukin-6	185,198	interleukin-1beta	44,61	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	LNCaP|nmod|START_ENTITY LNCaP|nsubj|Enhancement Enhancement|nmod|effects effects|nmod|END_ENTITY	Enhancement of antiproliferative effects of interleukin-1beta and tumor_necrosis_factor-alpha on human prostate_cancer LNCaP cells by coculture with normal fibroblasts through secreted interleukin-6 .
10590238	0	interleukin-6	21,34	interleukin-1beta	120,137	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	expression|amod|START_ENTITY expression|dep|synergy synergy|nmod|END_ENTITY	Oncostatin_M induces interleukin-6 and cyclooxygenase-2 expression in human vascular smooth muscle cells : synergy with interleukin-1beta .
11174046	0	interleukin-6	44,57	interleukin-1beta	25,42	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Plasma concentrations of interleukin-1beta , interleukin-6 , soluble interleukin-2 receptor and tumor necrosis factor alpha of depressed patients in Japan .
12165795	0	interleukin-6	67,80	interleukin-1beta	46,63	interleukin-6	interleukin-1beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Additive effects of amyloid beta fragment and interleukin-1beta on interleukin-6 secretion in rat primary glial cultures .
12668157	0	interleukin-6	15,28	interleukin-1beta	40,57	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Stimulation of interleukin-6 release by interleukin-1beta from isolated human adipocytes .
12873450	0	interleukin-6	47,60	interleukin-1beta	147,164	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	expression|amod|START_ENTITY baicalin|nmod|expression Effects|nmod|baicalin induced|nsubj|Effects induced|nmod|line line|amod|END_ENTITY	Effects of baicalin , baicalein , and wogonin on interleukin-6 and interleukin-8 expression , and nuclear_factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line .
12957790	0	interleukin-6	27,40	interleukin-1beta	55,72	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	expression|amod|START_ENTITY modulation|nmod|expression modulation|nmod|END_ENTITY	Differential modulation of interleukin-6 expression by interleukin-1beta in neuronal and glial cultures .
15716832	0	interleukin-6	41,54	interleukin-1beta	56,73	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	tumor|amod|START_ENTITY tumor|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , interleukin-6 , interleukin-1beta , soluble tumor necrosis factor receptors I and II , interleukin-6 soluble receptor , interleukin-1 soluble receptor type II , interleukin-1 receptor antagonist , and protein in the synovial fluid of patients with temporomandibular_joint_disorders .
8703029	0	interleukin-6	59,72	interleukin-1beta	38,55	interleukin-6	interleukin-1beta	16193(Tax:10090)	16176(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY END_ENTITY|nmod|mRNA	Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit_ligand and interleukin-10 in mouse bone marrow-derived mast cells .
9326296	0	interleukin-6	33,46	interleukin-1beta	177,194	interleukin-6	interleukin-1beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	encoding|dobj|START_ENTITY genes|acl|encoding Regulation|nmod|genes cytokine|nsubj|Regulation cytokine|xcomp|END_ENTITY	Regulation of the genes encoding interleukin-6 , its receptor , and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta .
9772027	0	interleukin-6	132,145	interleukin-1beta	113,130	interleukin-6	interleukin-1beta	3569	3553	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Longitudinal study of inflammatory factors in serum , cerebrospinal fluid , and brain tissue in Alzheimer_disease : interleukin-1beta , interleukin-6 , interleukin-1 receptor antagonist , tumor_necrosis_factor-alpha , the soluble tumor necrosis factor receptors I and II , and alpha1-antichymotrypsin .
12070682	0	interleukin-6	12,25	interleukin-2	35,48	interleukin-6	interleukin-2	3569	3558	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Circulating interleukin-6 , soluble interleukin-2 receptors , tumor_necrosis_factor_alpha , and interleukin-10 levels in juvenile_chronic_arthritis : correlations with soft tissue vascularity assessed by power Doppler sonography .
12223256	0	interleukin-6	24,37	interleukin-2	9,22	interleukin-6	interleukin-2	3569	3558	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Elevated interleukin-2 , interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia : association with psychopathology .
15531955	0	interleukin-6	21,34	interleukin-2	6,19	interleukin-6	interleukin-2	3569	3558	Gene	Gene	necrosis|dep|START_ENTITY necrosis|nsubj|END_ENTITY	Serum interleukin-2 , interleukin-6 , tumour necrosis factor-alpha and nitric_oxide levels in patients with Behcet 's _ disease .
16690518	0	interleukin-6	123,136	interleukin-2	84,97	interleukin-6	interleukin-2	3569	3558	Gene	Gene	interleukin-2|amod|START_ENTITY interleukin-2|appos|receptor receptor|compound|END_ENTITY	Aggressive_non-Hodgkin 's _ lymphoma : concomitant evaluation of interleukin-2 , soluble interleukin-2 receptor , interleukin-4 , interleukin-6 , interleukin-10 and correlation with outcome .
1704262	0	interleukin-6	104,117	interleukin-2	38,51	interleukin-6	interleukin-2	3569	3558	Gene	Gene	level|amod|START_ENTITY circulating|nmod|level kinetics|acl|circulating immunotherapy|dep|kinetics immunotherapy|nmod|END_ENTITY	Adoptive immunotherapy with high-dose interleukin-2 : kinetics of circulating progenitors correlate with interleukin-6 , granulocyte colony-stimulating factor level .
1827050	0	interleukin-6	12,25	interleukin-2	71,84	interleukin-6	interleukin-2	3569	3558	Gene	Gene	role|nmod|START_ENTITY role|dep|detection detection|nmod|RNA RNA|compound|END_ENTITY	The role of interleukin-6 in mitogenic T-cell activation : detection of interleukin-2 heteronuclear RNA by polymerase chain reaction .
1912580	0	interleukin-6	130,143	interleukin-2	191,204	interleukin-6	interleukin-2	3569	3558	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	In vivo production of interleukin-5 , granulocyte-macrophage colony-stimulating factor , macrophages colony-stimulating factor , and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients .
26555352	0	interleukin-6	15,28	interleukin-2	32,45	interleukin-6	interleukin-2	3569	3558	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Baseline serum interleukin-6 to interleukin-2 ratio is associated with the response to seasonal trivalent influenza vaccine in solid organ transplant recipients .
7719378	0	interleukin-6	36,49	interleukin-2	109,122	interleukin-6	interleukin-2	3569	3558	Gene	Gene	secretion|amod|START_ENTITY dependency|nmod|secretion subcutaneous|nsubj|dependency subcutaneous|dobj|END_ENTITY	In vivo time and dose dependency of interleukin-6 secretion in response to low-dose subcutaneous recombinant interleukin-2 .
8697075	0	interleukin-6	86,99	interleukin-2	21,34	interleukin-6	interleukin-2	16193(Tax:10090)	16183(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY gene-transfected|nmod|-RSB- gene-transfected|nsubj|effect effect|nmod|END_ENTITY	-LSB- Antitumor effect of interleukin-2 gene-transfected tumor vaccine in combination with interleukin-6 gene-transfected tumor vaccine -RSB- .
9135506	0	interleukin-6	63,76	interleukin-2	200,213	interleukin-6	interleukin-2	3569	3558	Gene	Gene	levels|nmod|START_ENTITY administration|nmod|levels effects|nmod|administration advanced|nsubj|effects advanced|nmod|immunotherapy immunotherapy|nmod|cancer cancer|nmod|END_ENTITY	Acute effects of pamidronate administration on serum levels of interleukin-6 in advanced solid tumour patients with bone metastases and their possible implications in the immunotherapy of cancer with interleukin-2 .
9474133	0	interleukin-6	6,19	interleukin-2	84,97	interleukin-6	interleukin-2	3569	3558	Gene	Gene	levels|amod|START_ENTITY levels|nmod|metastatic_renal_cell_carcinoma metastatic_renal_cell_carcinoma|nmod|treatment treatment|nmod|END_ENTITY	Serum interleukin-6 levels in metastatic_renal_cell_carcinoma before treatment with interleukin-2 correlates with paraneoplastic_syndromes but not patient survival .
16690518	0	interleukin-6	123,136	interleukin-4	108,121	interleukin-6	interleukin-4	3569	3565	Gene	Gene	interleukin-2|amod|START_ENTITY interleukin-2|appos|END_ENTITY	Aggressive_non-Hodgkin 's _ lymphoma : concomitant evaluation of interleukin-2 , soluble interleukin-2 receptor , interleukin-4 , interleukin-6 , interleukin-10 and correlation with outcome .
1912557	0	interleukin-6	76,89	interleukin-4	14,27	interleukin-6	interleukin-4	16193(Tax:10090)	16189(Tax:10090)	Gene	Gene	myeloid|advcl|START_ENTITY myeloid|nsubj|Regulation Regulation|nmod|receptors receptors|compound|END_ENTITY	Regulation of interleukin-4 receptors on murine myeloid progenitor cells by interleukin-6 .
8464242	0	interleukin-6	150,163	interleukin-4	21,34	interleukin-6	interleukin-4	3569	3565	Gene	Gene	role|nmod|START_ENTITY effect|dep|role effect|nmod|END_ENTITY	Inhibitory effect of interleukin-4 on the proliferation of acute_myeloid_leukemia cells with myelo-monocytic differentiation -LRB- AML-M4 / M5 -RRB- ; the role of interleukin-6 .
11197112	0	interleukin-6	35,48	interleukin-5	20,33	interleukin-6	interleukin-5	3569	3567	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Interleukin-1_beta , interleukin-5 , interleukin-6 , interleukin-8 , and tumor_necrosis_factor-alpha in chronic sinusitis : response to systemic corticosteroids .
10626661	0	interleukin-6	21,34	interleukin-6	47,60	interleukin-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Neurotrophic role of interleukin-6 and soluble interleukin-6 receptors in N1E-115 neuroblastoma cells .
10626661	0	interleukin-6	47,60	interleukin-6	21,34	interleukin-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Neurotrophic role of interleukin-6 and soluble interleukin-6 receptors in N1E-115 neuroblastoma cells .
11389214	0	interleukin-6	57,70	interleukin-6	96,109	interleukin-6	interleukin-6	3569	3569	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Carbohydrate ingestion attenuates the increase in plasma interleukin-6 , but not skeletal muscle interleukin-6 mRNA , during exercise in humans .
11389214	0	interleukin-6	96,109	interleukin-6	57,70	interleukin-6	interleukin-6	3569	3569	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Carbohydrate ingestion attenuates the increase in plasma interleukin-6 , but not skeletal muscle interleukin-6 mRNA , during exercise in humans .
11703956	0	interleukin-6	41,54	interleukin-6	58,71	interleukin-6	interleukin-6	3569	3569	Gene	Gene	START_ENTITY|nmod|levels levels|amod|END_ENTITY	Relation of the -174 _ G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization .
11703956	0	interleukin-6	58,71	interleukin-6	41,54	interleukin-6	interleukin-6	3569	3569	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Relation of the -174 _ G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization .
12412787	0	interleukin-6	12,25	interleukin-6	26,39	interleukin-6	interleukin-6	3569	3569	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Role of the interleukin-6 / interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid_hormone in perimenopausal women .
12412787	0	interleukin-6	26,39	interleukin-6	12,25	interleukin-6	interleukin-6	3569	3569	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Role of the interleukin-6 / interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid_hormone in perimenopausal women .
16325417	0	interleukin-6	108,121	interleukin-6	130,143	interleukin-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6 / soluble interleukin-6 receptor fusion protein .
16325417	0	interleukin-6	130,143	interleukin-6	108,121	interleukin-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6 / soluble interleukin-6 receptor fusion protein .
19527938	0	interleukin-6	42,55	interleukin-6	56,69	interleukin-6	interleukin-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The response of circulating levels of the interleukin-6 / interleukin-6 receptor complex to exercise in young men .
19527938	0	interleukin-6	56,69	interleukin-6	42,55	interleukin-6	interleukin-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The response of circulating levels of the interleukin-6 / interleukin-6 receptor complex to exercise in young men .
19790045	0	interleukin-6	65,78	interleukin-6	92,105	interleukin-6	interleukin-6	280826(Tax:9913)	280826(Tax:9913)	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Mechanical_injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor_necrosis_factor_alpha in immature bovine and adult human articular cartilage .
19790045	0	interleukin-6	92,105	interleukin-6	65,78	interleukin-6	interleukin-6	280826(Tax:9913)	280826(Tax:9913)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Mechanical_injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor_necrosis_factor_alpha in immature bovine and adult human articular cartilage .
7957676	0	interleukin-6	102,115	interleukin-6	76,89	interleukin-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor .
7957676	0	interleukin-6	76,89	interleukin-6	102,115	interleukin-6	interleukin-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor .
8020547	0	interleukin-6	27,40	interleukin-6	54,67	interleukin-6	interleukin-6	3569	3569	Gene	Gene	receptors|amod|START_ENTITY regulation|nmod|receptors regulation|nmod|END_ENTITY	Differential regulation of interleukin-6 receptors by interleukin-6 and interferons in multiple_myeloma cell lines .
8020547	0	interleukin-6	54,67	interleukin-6	27,40	interleukin-6	interleukin-6	3569	3569	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|receptors receptors|amod|END_ENTITY	Differential regulation of interleukin-6 receptors by interleukin-6 and interferons in multiple_myeloma cell lines .
8543847	0	interleukin-6	12,25	interleukin-6	38,51	interleukin-6	interleukin-6	3569	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	-LSB- A study of interleukin-6 and soluble interleukin-6 receptors during pregnancy and delivery -RSB- .
8543847	0	interleukin-6	38,51	interleukin-6	12,25	interleukin-6	interleukin-6	3569	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	-LSB- A study of interleukin-6 and soluble interleukin-6 receptors during pregnancy and delivery -RSB- .
9461605	0	interleukin-6	21,34	interleukin-6	47,60	interleukin-6	interleukin-6	3569	3569	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Oncostatin_M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes .
9461605	0	interleukin-6	47,60	interleukin-6	21,34	interleukin-6	interleukin-6	3569	3569	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Oncostatin_M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes .
9610741	0	interleukin-6	15,28	interleukin-6	41,54	interleukin-6	interleukin-6	3569	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells .
9610741	0	interleukin-6	41,54	interleukin-6	15,28	interleukin-6	interleukin-6	3569	3569	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells .
10633884	0	interleukin-6	74,87	interleukin-6_receptor	16,38	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	gingival|amod|START_ENTITY fibroblasts|amod|gingival Role|nmod|fibroblasts Role|nmod|END_ENTITY	Role of soluble interleukin-6_receptor in inflamed gingiva for binding of interleukin-6 to gingival fibroblasts .
11504839	0	interleukin-6	14,27	interleukin-6_receptor	29,51	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	gp80|amod|START_ENTITY gp80|amod|END_ENTITY	Expression of interleukin-6 , interleukin-6_receptor -LRB- gp80 -RRB- , and the receptor 's signal-transducing subunit -LRB- gp130 -RRB- in human normal pituitary glands and pituitary_adenomas .
12664314	0	interleukin-6	61,74	interleukin-6_receptor	126,148	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding Polymorphisms|nmod|gene determine|nsubj|Polymorphisms determine|dobj|magnitude magnitude|nmod|increase increase|nmod|levels levels|amod|END_ENTITY	Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6_receptor levels in Alzheimer 's _ disease .
14557255	0	interleukin-6	28,41	interleukin-6_receptor	65,87	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	epitope|amod|START_ENTITY epitope|nmod|spectroscopy spectroscopy|amod|END_ENTITY	Direct determination of the interleukin-6 binding epitope of the interleukin-6_receptor by NMR spectroscopy .
15129368	0	interleukin-6	4,17	interleukin-6_receptor	26,48	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	system|dep|START_ENTITY system|amod|END_ENTITY	The interleukin-6 / soluble interleukin-6_receptor system induces parathyroid_hormone-related_protein in human osteoblastic cells .
16096463	0	interleukin-6	15,28	interleukin-6_receptor	37,59	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	Changes|nmod|START_ENTITY Changes|dep|axis axis|amod|END_ENTITY	Changes in the interleukin-6 / soluble interleukin-6_receptor axis in meningococcal septic_shock .
16512982	0	interleukin-6	10,23	interleukin-6_receptor	24,46	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	stimulation|dep|START_ENTITY stimulation|amod|END_ENTITY	Autocrine interleukin-6 / interleukin-6_receptor stimulation in non-small-cell_lung_cancer .
17549633	0	interleukin-6	6,19	interleukin-6_receptor	29,51	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	soluble|amod|START_ENTITY END_ENTITY|amod|soluble	Serum interleukin-6 , soluble interleukin-6_receptor and Crohn 's _ disease activity .
17978466	0	interleukin-6	44,57	interleukin-6_receptor	137,159	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	immunopathophysiology|nmod|START_ENTITY advances|nmod|immunopathophysiology advances|dep|drug drug|appos|tocilizumab tocilizumab|dep|antibody antibody|amod|END_ENTITY	Recent advances in immunopathophysiology of interleukin-6 : an innovative therapeutic drug , tocilizumab -LRB- recombinant humanized anti-human interleukin-6_receptor antibody -RRB- , unveils the mysterious etiology of immune-mediated inflammatory diseases .
19264784	0	interleukin-6	17,30	interleukin-6_receptor	111,133	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	binding|amod|START_ENTITY Unraveling|dobj|binding pathways|csubj|Unraveling pathways|nmod|END_ENTITY	Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6_receptor .
20396982	0	interleukin-6	16,29	interleukin-6_receptor	42,64	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	The response of interleukin-6 and soluble interleukin-6_receptor isoforms following intermittent high intensity and continuous moderate intensity cycling .
23172750	0	interleukin-6	47,60	interleukin-6_receptor	82,104	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	effects|acl|START_ENTITY blocking|dobj|effects blocking|nmod|inhibition inhibition|amod|END_ENTITY	Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6_receptor inhibition in rheumatoid_arthritis and other inflammatory conditions .
25151086	0	interleukin-6	33,46	interleukin-6_receptor	55,77	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	suppresses|dep|START_ENTITY suppresses|dep|induced-secretion induced-secretion|amod|END_ENTITY	Synthetic -LRB- + -RRB- - terrein suppresses interleukin-6 / soluble interleukin-6_receptor induced-secretion of vascular_endothelial_growth_factor in human gingival fibroblasts .
25245339	0	interleukin-6	46,59	interleukin-6_receptor	23,45	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	complex|amod|START_ENTITY Interleukin-6|dep|complex Interleukin-6|amod|END_ENTITY	Interleukin-6 , soluble interleukin-6_receptor / interleukin-6 complex and insulin resistance in obese children and adolescents .
25856562	0	interleukin-6	21,34	interleukin-6_receptor	42,64	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	effects|nmod|START_ENTITY /|nsubj|effects /|dobj|IL-6R IL-6R|amod|END_ENTITY	Antitumor effects of interleukin-6 -LRB- IL-6 -RRB- / interleukin-6_receptor -LRB- IL-6R -RRB- signaling pathway inhibition in clear_cell_carcinoma_of_the_ovary .
7674091	0	interleukin-6	14,27	interleukin-6_receptor	40,62	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	The effect of interleukin-6 and soluble interleukin-6_receptor protein on the bone resorptive activity of human osteoclasts generated in vitro .
7713920	0	interleukin-6	33,46	interleukin-6_receptor	96,118	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	mutations|nmod|START_ENTITY Combining|dobj|mutations affect|dep|Combining affect|nmod|antagonist antagonist|amod|END_ENTITY	Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6_receptor antagonist on human myeloma cells .
8083235	0	interleukin-6	96,109	interleukin-6_receptor	14,36	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	consisting|advcl|START_ENTITY complex|acl|consisting complex|nsubj|High High|amod|END_ENTITY	High affinity interleukin-6_receptor is a hexameric complex consisting of two molecules each of interleukin-6 , interleukin-6_receptor , and gp-130 .
8200444	0	interleukin-6	51,64	interleukin-6_receptor	14,36	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of interleukin-6_receptor expression by interleukin-6 in human monocytes -- a re-examination .
8392518	1	interleukin-6	147,160	interleukin-6_receptor	216,238	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	Evidence|amod|START_ENTITY acts|nsubj|Evidence acts|nmod|receptor receptor|amod|different different|nmod|END_ENTITY	Evidence that interleukin-6 possibly acts via a receptor different from the 80-kDa interleukin-6_receptor .
8420983	0	interleukin-6	22,35	interleukin-6_receptor	68,90	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	association|nmod|START_ENTITY association|nmod|component component|nmod|system system|amod|END_ENTITY	Direct association of interleukin-6 with a 130-kDa component of the interleukin-6_receptor system .
8651752	0	interleukin-6	105,118	interleukin-6_receptor	38,60	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	stimulation|amod|START_ENTITY facilitates|dobj|stimulation facilitates|nsubj|induction induction|nmod|expression expression|amod|END_ENTITY	Glucocorticoid-dependent induction of interleukin-6_receptor expression in human hepatocytes facilitates interleukin-6 stimulation of amino_acid transport .
9615791	0	interleukin-6	84,97	interleukin-6_receptor	58,80	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	blocking|advcl|START_ENTITY blocking|nmod|END_ENTITY	In vivo blocking effects of a humanized antibody to human interleukin-6_receptor on interleukin-6 function in primates .
9645958	0	interleukin-6	113,126	interleukin-6_receptor	90,112	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	complex|amod|START_ENTITY complex|dep|transcription transcription|nmod|END_ENTITY	Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6_receptor / interleukin-6 complex .
9867112	0	interleukin-6	10,23	interleukin-6_receptor	32,54	interleukin-6	interleukin-6 receptor	3569	3570	Gene	Gene	levels|amod|START_ENTITY levels|appos|expression expression|amod|END_ENTITY	Increased interleukin-6 levels , interleukin-6_receptor and gp130 expression in peripheral lymphocytes of patients with inflammatory_bowel_disease .
10476751	0	interleukin-6	46,59	interleukin-8	61,74	interleukin-6	interleukin-8	3569	3576	Gene	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Assessment of measuring circulating levels of interleukin-6 , interleukin-8 , C-reactive_protein , soluble Fc gamma receptor type III , and mannose-binding_protein in febrile children with cancer and neutropenia .
20709566	0	interleukin-6	71,84	interleukin-8_and_tumor_necrosis_factor_alpha	86,131	interleukin-6	interleukin-8 and tumor necrosis factor alpha	3569	3576;7124	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Paget 's _ disease_of_bone is not associated with common polymorphisms in interleukin-6 , interleukin-8_and_tumor_necrosis_factor_alpha genes .
7836389	0	interleukin-6	107,120	junB	77,81	interleukin-6	junB	16193(Tax:10090)	16477(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY transcription|acl|induced transcription|compound|END_ENTITY	Two distinct signalling pathways are involved in the control of the biphasic junB transcription induced by interleukin-6 in the B cell hybridoma 7TD1 .
1421375	0	interleukin-6	58,71	leukemia_inhibitory_factor	80,106	interleukin-6	leukemia inhibitory factor	3569	3976	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Involvement of nuclear factor-kappa B in induction of the interleukin-6 gene by leukemia_inhibitory_factor .
15684762	0	interleukin-6	80,93	matrix_metalloproteinase-9	10,36	interleukin-6	matrix metalloproteinase-9	3569	4318	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Increased matrix_metalloproteinase-9 in blood in association with activation of interleukin-6 after traumatic_brain_injury : influence of hypothermic therapy .
24641842	0	interleukin-6	33,46	miR-149	22,29	interleukin-6	miR-149	3569	406941	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Regulatory effect of miR-149 on interleukin-6 expression in silica-induced pulmonary_fibrosis -RSB- .
16407046	0	interleukin-6	94,107	monocyte_chemoattractant_protein_1	58,92	interleukin-6	monocyte chemoattractant protein 1	3569	6347	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Interleukin-4_and_13 induce the expression and release of monocyte_chemoattractant_protein_1 , interleukin-6 and stem_cell_factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha .
21868713	0	interleukin-6	100,113	mucin	132,137	interleukin-6	mucin	3569	100508689	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Epidermal_growth_factor_receptor signaling mediates vesicant-induced airway epithelial secretion of interleukin-6 and production of mucin .
10501190	0	interleukin-6	19,32	nuclear_factor-kappaB	80,101	interleukin-6	nuclear factor-kappaB	3569	4790	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear_factor-kappaB .
11431008	0	interleukin-6	14,27	nuclear_factor_kappaB	69,90	interleukin-6	nuclear factor kappaB	16193(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of interleukin-6 gene expression in brain of aged mice by nuclear_factor_kappaB .
11830554	0	interleukin-6	10,23	p53	92,95	interleukin-6	p53	3569	7157	Gene	Gene	production|amod|START_ENTITY production|dep|evidence evidence|nmod|involvement involvement|nmod|END_ENTITY	Autocrine interleukin-6 production in renal_cell_carcinoma : evidence for the involvement of p53 .
1852210	0	interleukin-6	80,93	p53	10,13	interleukin-6	p53	16193(Tax:10090)	22060(Tax:10090)	Gene	Gene	inhibited|advcl|START_ENTITY apoptosis|acl:relcl|inhibited induces|dobj|apoptosis induces|nsubj|END_ENTITY	Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 .
23675777	0	interleukin-6	25,38	p53	53,56	interleukin-6	p53	16193(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of myocardial interleukin-6 expression by p53 and STAT1 .
8247009	0	interleukin-6	36,49	p53	29,32	interleukin-6	p53	3569	7157	Gene	Gene	effects|amod|START_ENTITY END_ENTITY|nmod|effects	Complementation by wild-type p53 of interleukin-6 effects on M1 cells : induction of cell cycle exit and cooperativity with c-myc suppression .
8325885	0	interleukin-6	24,37	p53	111,114	interleukin-6	p53	3569	7157	Gene	Gene	promoter|amod|START_ENTITY Modulation|nmod|promoter C/EBP|nsubj|Modulation C/EBP|xcomp|_ _|dobj|activity activity|nmod|species species|compound|END_ENTITY	Modulation of the human interleukin-6 promoter -LRB- IL-6 -RRB- and transcription factor C/EBP _ beta -LRB- NF-IL6 -RRB- activity by p53 species .
10804018	0	interleukin-6	32,45	parathyroid_hormone	60,79	interleukin-6	parathyroid hormone	24498(Tax:10116)	24694(Tax:10116)	Gene	Gene	production|amod|START_ENTITY kinase|nmod|production kinase|nmod|END_ENTITY	Protein kinase C involvement in interleukin-6 production by parathyroid_hormone and tumor_necrosis_factor-alpha in UMR-106 osteoblastic cells .
11450697	0	interleukin-6	15,28	parathyroid_hormone	41,60	interleukin-6	parathyroid hormone	24498(Tax:10116)	24694(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Stimulation of interleukin-6 promoter by parathyroid_hormone , tumor_necrosis_factor_alpha , and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein_kinase_C antagonists .
12412787	0	interleukin-6	12,25	parathyroid_hormone	120,139	interleukin-6	parathyroid hormone	3569	5741	Gene	Gene	system|amod|START_ENTITY Role|nmod|system increased|nsubj|Role increased|advcl|END_ENTITY	Role of the interleukin-6 / interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid_hormone in perimenopausal women .
12412787	0	interleukin-6	26,39	parathyroid_hormone	120,139	interleukin-6	parathyroid hormone	3569	5741	Gene	Gene	system|amod|START_ENTITY Role|nmod|system increased|nsubj|Role increased|advcl|END_ENTITY	Role of the interleukin-6 / interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid_hormone in perimenopausal women .
8631918	0	interleukin-6	38,51	parathyroid_hormone	15,34	interleukin-6	parathyroid hormone	3569	5741	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Stimulation by parathyroid_hormone of interleukin-6 and leukemia_inhibitory_factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction .
8725172	0	interleukin-6	126,139	parathyroid_hormone	27,46	interleukin-6	parathyroid hormone	16193(Tax:10090)	19226(Tax:10090)	Gene	Gene	osteoblasts|nmod|START_ENTITY stimulate|nmod|osteoblasts stimulate|nsubj|protein protein|amod|END_ENTITY	In vivo demonstration that parathyroid_hormone and parathyroid_hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia_inhibitory_factor .
9169347	0	interleukin-6	93,106	parathyroid_hormone	46,65	interleukin-6	parathyroid hormone	3569	5741	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Involvement of different second messengers in parathyroid_hormone - and interleukin-1-induced interleukin-6 and interleukin-11 production in human bone marrow stromal cells .
19289654	0	interleukin-6	50,63	peroxisome_proliferator-activated_receptor-gamma	112,160	interleukin-6	peroxisome proliferator-activated receptor-gamma	24498(Tax:10116)	25664(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome_proliferator-activated_receptor-gamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta .
26763395	0	interleukin-6	32,45	phospholipase_D1	73,89	interleukin-6	phospholipase D1	3569	5337	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase_D1 in human bronchial epithelial cells .
12783695	0	interleukin-6	32,45	placental_growth_factor	49,72	interleukin-6	placental growth factor	3569	5228	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Study on regulatory effects of interleukin-6 on placental_growth_factor expression in trophoblast cells -RSB- .
9116283	0	interleukin-6	45,58	plasminogen	14,25	interleukin-6	plasminogen	3569	5340	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of plasminogen gene expression by interleukin-6 .
21945780	0	interleukin-6	33,46	prolactin	20,29	interleukin-6	prolactin	3569	5617	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	-LSB- Influence of serum prolactin on interleukin-6 secretion by peripheral blood mononuclear cells in patients with systemic_lupus_erythematosus -RSB- .
8248548	0	interleukin-6	11,24	prostaglandin	60,73	interleukin-6	interleukin-6	3569	3569	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of interleukin-6 and tumor_necrosis_factor-alpha on prostaglandin production by cultured human fetal membranes .
15994976	0	interleukin-6	135,148	prostate-specific_antigen	59,84	interleukin-6	prostate-specific antigen	3569	354	Gene	Gene	chronically|advcl|START_ENTITY treated|xcomp|chronically cells|acl|treated END_ENTITY|nmod|cells	p300 regulates androgen_receptor-independent expression of prostate-specific_antigen in prostate_cancer cells treated chronically with interleukin-6 .
21051589	0	interleukin-6	20,33	prostate-specific_antigen	44,69	interleukin-6	prostate-specific antigen	3569	354	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Mechanisms by which interleukin-6 regulates prostate-specific_antigen gene expression in prostate LNCaP carcinoma cells .
24096654	0	interleukin-6	92,105	serum_amyloid_A	44,59	interleukin-6	serum amyloid A	3569	6287	Gene	Gene	activation|nmod|START_ENTITY upregulates|nmod|activation upregulates|dobj|synthesis synthesis|compound|END_ENTITY	Calcitonin_gene-related_peptide upregulates serum_amyloid_A synthesis through activation of interleukin-6 .
9933631	0	interleukin-6	175,188	serum_amyloid_A	192,207	interleukin-6	serum amyloid A	3569	6287	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Activation of Sp1 and its functional co-operation with serum_amyloid_A-activating sequence binding factor in synoviocyte cells trigger synergistic action of interleukin-1 and interleukin-6 in serum_amyloid_A gene expression .
16278387	0	interleukin-6	95,108	signal_transducer_and_activator_of_transcription_3	41,91	interleukin-6	signal transducer and activator of transcription 3	3569	6774	Gene	Gene	lung_cancer|amod|START_ENTITY activation|nmod|lung_cancer activation|nmod|END_ENTITY	Cyclooxygenase-2-dependent activation of signal_transducer_and_activator_of_transcription_3 by interleukin-6 in non-small cell lung_cancer .
17935227	0	interleukin-6	104,117	signal_transducer_and_activator_of_transcription_3	118,168	interleukin-6	signal transducer and activator of transcription 3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6 / signal_transducer_and_activator_of_transcription_3 activity .
19147545	0	interleukin-6	40,53	signal_transducer_and_activator_of_transcription_3	66,116	interleukin-6	signal transducer and activator of transcription 3	3569	6774	Gene	Gene	START_ENTITY|xcomp|activate activate|dobj|END_ENTITY	The Fer tyrosine kinase cooperates with interleukin-6 to activate signal_transducer_and_activator_of_transcription_3 and promote human prostate_cancer cell growth .
21940958	0	interleukin-6	19,32	signal_transducer_and_activator_of_transcription_3	48,98	interleukin-6	signal transducer and activator of transcription 3	16193(Tax:10090)	20848(Tax:10090)	Gene	Gene	Neuroprotection|nmod|START_ENTITY mediated|nsubjpass|Neuroprotection mediated|nmod|END_ENTITY	Neuroprotection by interleukin-6 is mediated by signal_transducer_and_activator_of_transcription_3 and antioxidative signaling in ischemic_stroke .
23622344	0	interleukin-6	18,31	signal_transducer_and_activator_of_transcription_3	62,112	interleukin-6	signal transducer and activator of transcription 3	3569	6774	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Leptin stimulates interleukin-6 production via janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 in rheumatoid synovial fibroblasts .
9670861	0	interleukin-6	46,59	transforming_growth_factor-beta1	10,42	interleukin-6	transforming growth factor-beta1	3569	7040	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of transforming_growth_factor-beta1 on interleukin-6 secretion in human myoblasts .
7765354	0	interleukin-6	19,32	transglutaminase	74,90	interleukin-6	transglutaminase	106027696	100379228(Tax:10141)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Increase caused by interleukin-6 in promoter activity of guinea_pig liver transglutaminase gene .
11007957	0	interleukin-6	94,107	tumor_necrosis_factor	23,44	interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Signal transduction by tumor_necrosis_factor and gene regulation of the inflammatory cytokine interleukin-6 .
12923493	0	interleukin-6	185,198	tumor_necrosis_factor	109,130	interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	enhances|nsubj|START_ENTITY lipopolysaccharide|advcl|enhances lipopolysaccharide|nsubj|Modulation Modulation|nmod|expression expression|nmod|monocytes monocytes|nmod|evokes evokes|compound|END_ENTITY	Modulation of toll-like_receptor_4 expression on human monocytes by tumor_necrosis_factor and interleukin-6 : tumor_necrosis_factor evokes lipopolysaccharide hyporesponsiveness , whereas interleukin-6 enhances lipopolysaccharide activity .
12923493	0	interleukin-6	185,198	tumor_necrosis_factor	68,89	interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	enhances|nsubj|START_ENTITY lipopolysaccharide|advcl|enhances lipopolysaccharide|nsubj|Modulation Modulation|nmod|expression expression|nmod|monocytes monocytes|nmod|evokes evokes|compound|END_ENTITY	Modulation of toll-like_receptor_4 expression on human monocytes by tumor_necrosis_factor and interleukin-6 : tumor_necrosis_factor evokes lipopolysaccharide hyporesponsiveness , whereas interleukin-6 enhances lipopolysaccharide activity .
15906094	0	interleukin-6	21,34	tumor_necrosis_factor	54,75	interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Association tests of interleukin-6 -LRB- IL-6 -RRB- and type II tumor_necrosis_factor receptor -LRB- TNFR2 -RRB- genes with bone_mineral_density in Caucasians using a re-sampling approach .
7852449	1	interleukin-6	81,94	tumor_necrosis_factor	43,64	interleukin-6	tumor necrosis factor	106027696	100135630(Tax:10141)	Gene	Gene	interleukin-1|nummod|START_ENTITY interleukin-1|compound|END_ENTITY	The production of tumor_necrosis_factor , interleukin-1 , interleukin-6 , and prostaglandin_E2 by isolated enterocytes and gut macrophages : effect of lipopolysaccharide and thermal_injury .
8034659	0	interleukin-6	30,43	tumor_necrosis_factor	52,73	interleukin-6	tumor necrosis factor	3569	7124	Gene	Gene	gene|amod|START_ENTITY induction|nmod|gene induction|nmod|END_ENTITY	Differential induction of the interleukin-6 gene by tumor_necrosis_factor and interleukin-1 .
9811328	0	interleukin-6	119,132	tumor_necrosis_factor	199,220	interleukin-6	tumor necrosis factor	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nmod|mice mice|dep|comparison comparison|nmod|ligands ligands|nmod|superfamily superfamily|compound|END_ENTITY	Intracerebroventricular injection of anti-Fas activates the hypothalamus-pituitary-adrenal_axis and induces peripheral interleukin-6 and serum_amyloid_A in mice : comparison with other ligands of the tumor_necrosis_factor / nerve growth factor receptor superfamily .
24891006	0	interleukin-6	13,26	tumor_necrosis_factor-a	46,69	interleukin-6	tumor necrosis factor-a	3569	7124	Gene	Gene	Elevation|nmod|START_ENTITY Elevation|nmod|END_ENTITY	Elevation of interleukin-6 and attenuation of tumor_necrosis_factor-a during wheelchair half marathon in athletes with cervical spinal_cord_injuries .
10669346	0	interleukin-6	74,87	tumor_necrosis_factor-alpha	45,72	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	concentrations|amod|START_ENTITY concentrations|dep|END_ENTITY	Prognostic value of cytokine concentrations -LRB- tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-10 -RRB- and clinical parameters in severe melioidosis .
11071592	0	interleukin-6	117,130	tumor_necrosis_factor-alpha	131,158	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	response|amod|START_ENTITY response|compound|END_ENTITY	Survival of malnourished_head_and_neck_cancer patients can be predicted by human leukocyte antigen-DR expression and interleukin-6 / tumor_necrosis_factor-alpha response of the monocyte .
11549342	0	interleukin-6	18,31	tumor_necrosis_factor-alpha	83,110	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	viral_myocarditis|amod|START_ENTITY Overexpression|nmod|viral_myocarditis Overexpression|dep|increase increase|nmod|END_ENTITY	Overexpression of interleukin-6 aggravates viral_myocarditis : impaired increase in tumor_necrosis_factor-alpha .
14692886	0	interleukin-6	56,69	tumor_necrosis_factor-alpha	27,54	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	interleukin-10|dep|START_ENTITY interleukin-10|compound|END_ENTITY	Investigation of cytokine -LRB- tumor_necrosis_factor-alpha , interleukin-6 , interleukin-10 -RRB- concentrations in the cerebrospinal fluid of female patients with multiple_sclerosis and systemic_lupus_erythematosus .
15102517	0	interleukin-6	47,60	tumor_necrosis_factor-alpha	114,141	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	release|amod|START_ENTITY sensitivity|nmod|release glucocorticoid|dobj|sensitivity glucocorticoid|nmod|levels levels|nmod|END_ENTITY	Reduced glucocorticoid sensitivity of monocyte interleukin-6 release in male employees with high plasma levels of tumor_necrosis_factor-alpha .
15190958	0	interleukin-6	106,119	tumor_necrosis_factor-alpha	153,180	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Hyperglycemia at admission to the intensive care unit is associated with elevated serum concentrations of interleukin-6 and reduced ex vivo secretion of tumor_necrosis_factor-alpha .
15203561	0	interleukin-6	45,58	tumor_necrosis_factor-alpha	16,43	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of tumor_necrosis_factor-alpha , interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter_pylori-associated gastritis .
15716832	0	interleukin-6	41,54	tumor_necrosis_factor-alpha	12,39	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	tumor|amod|START_ENTITY tumor|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , interleukin-6 , interleukin-1beta , soluble tumor necrosis factor receptors I and II , interleukin-6 soluble receptor , interleukin-1 soluble receptor type II , interleukin-1 receptor antagonist , and protein in the synovial fluid of patients with temporomandibular_joint_disorders .
16731080	0	interleukin-6	98,111	tumor_necrosis_factor-alpha	36,63	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Multilocus interactions at maternal tumor_necrosis_factor-alpha , tumor necrosis factor receptors , interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm_labor in European-American women .
1727819	0	interleukin-6	102,115	tumor_necrosis_factor-alpha	20,47	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	using|dobj|START_ENTITY gonadotropin|acl|using release|nmod|gonadotropin induces|dobj|release induces|nsubj|END_ENTITY	Trophoblast-derived tumor_necrosis_factor-alpha induces release of human chorionic gonadotropin using interleukin-6 -LRB- IL-6 -RRB- and IL-6-receptor-dependent system in the normal human trophoblasts .
1768380	0	interleukin-6	6,19	tumor_necrosis_factor-alpha	77,104	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	concentrations|amod|START_ENTITY elevated|nsubjpass|concentrations elevated|nmod|END_ENTITY	Serum interleukin-6 concentrations are elevated and associated with elevated tumor_necrosis_factor-alpha and immunoglobulin G and A concentrations in children with HIV_infection .
18162526	0	interleukin-6	162,175	tumor_necrosis_factor-alpha	29,56	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	changes|nmod|START_ENTITY cells|nmod|changes surface|nmod|cells transporter-4|nmod|surface increases|xcomp|transporter-4 increases|nsubj|END_ENTITY	The proinflammatory cytokine tumor_necrosis_factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6 .
18515973	0	interleukin-6	30,43	tumor_necrosis_factor-alpha	91,118	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	START_ENTITY|nmod|mechanisms mechanisms|acl:relcl|distinct distinct|nmod|those those|nmod|END_ENTITY	7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor_necrosis_factor-alpha , in vascular smooth muscle cells .
18534002	0	interleukin-6	66,79	tumor_necrosis_factor-alpha	37,64	interleukin-6	tumor necrosis factor-alpha	16193(Tax:10090)	21926(Tax:10090)	Gene	Gene	immunoglobulin|amod|START_ENTITY immunoglobulin|amod|END_ENTITY	Therapeutic effects of antibodies to tumor_necrosis_factor-alpha , interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate_isomerase induced arthritis .
2226778	0	interleukin-6	27,40	tumor_necrosis_factor-alpha	76,103	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of interleukin-6 expression in human fibroblasts by tumor_necrosis_factor-alpha and lymphotoxin .
7482719	0	interleukin-6	16,29	tumor_necrosis_factor-alpha	31,58	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	The relation of interleukin-6 , tumor_necrosis_factor-alpha , IL-2 , and IL-2_receptor levels to cellular rejection , allograft_dysfunction , and clinical events early after cardiac transplantation .
8015641	0	interleukin-6	81,94	tumor_necrosis_factor-alpha	52,79	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Effect of hemodialysis on peripheral blood monocyte tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-8 secretion in vitro .
8649562	0	interleukin-6	81,94	tumor_necrosis_factor-alpha	39,66	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	production|amod|START_ENTITY END_ENTITY|dobj|production	Interferon-beta 1b treatment decreases tumor_necrosis_factor-alpha and increases interleukin-6 production in multiple_sclerosis .
9226842	0	interleukin-6	52,65	tumor_necrosis_factor-alpha	23,50	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	cells|amod|START_ENTITY stimulated|nsubj|cells stimulated|nmod|production production|nmod|END_ENTITY	In vitro production of tumor_necrosis_factor-alpha , interleukin-6 and interleukin-8 from normal human peripheral blood mononuclear cells stimulated by Rhodococcus_equi .
9588580	0	interleukin-6	110,123	tumor_necrosis_factor-alpha	12,39	interleukin-6	tumor necrosis factor-alpha	3569	7124	Gene	Gene	receptor|amod|START_ENTITY relation|nmod|receptor levels|dep|relation levels|amod|END_ENTITY	Circulating tumor_necrosis_factor-alpha levels in chronic_heart_failure : relation to its soluble receptor II , interleukin-6 , and neurohumoral variables .
10089067	0	interleukin-6	29,42	tumor_necrosis_factor_alpha	73,100	interleukin-6	tumor necrosis factor alpha	3569	7124	Gene	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Transient increase of plasma interleukin-6 after infusion of recombinant tumor_necrosis_factor_alpha in advanced cancer patients .
15938966	0	interleukin-6	49,62	tumor_necrosis_factor_alpha	20,47	interleukin-6	tumor necrosis factor alpha	24498(Tax:10116)	24835(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY -RSB-|nsubj|levels -RSB-|advcl|-LSB- -LSB-|nmod|END_ENTITY	-LSB- The changes in the tumor_necrosis_factor_alpha , interleukin-6 and interleukin-8 levels in the lymph and of the dynamics of the lymphokines during shock stage of rats with major burns -RSB- .
2265482	0	interleukin-6	34,47	tumour_necrosis_factor	66,88	interleukin-6	tumour necrosis factor	3569	7124	Gene	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Dose-dependent increase in plasma interleukin-6 after recombinant tumour_necrosis_factor infusion in humans .
7772629	0	interleukin-6	108,121	tumour_necrosis_factor	84,106	interleukin-6	tumour necrosis factor	106027696	100135630(Tax:10141)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Effect of hepatocytes from normal or endotoxin treated animals on the production of tumour_necrosis_factor , interleukin-6 , and prostaglandin-E2 by macrophages incubated in vitro with various fatty_acids .
25110587	0	interleukin-6	8,21	vascular_endothelial_growth_factor	45,79	interleukin-6	vascular endothelial growth factor	3569	7422	Gene	Gene	levels|amod|START_ENTITY superior|nsubj|levels superior|xcomp|END_ENTITY	Aqueous interleukin-6 levels are superior to vascular_endothelial_growth_factor in predicting therapeutic response to bevacizumab in age-related_macular_degeneration .
25151086	0	interleukin-6	33,46	vascular_endothelial_growth_factor	99,133	interleukin-6	vascular endothelial growth factor	3569	7422	Gene	Gene	suppresses|dep|START_ENTITY suppresses|dep|induced-secretion induced-secretion|nmod|END_ENTITY	Synthetic -LRB- + -RRB- - terrein suppresses interleukin-6 / soluble interleukin-6_receptor induced-secretion of vascular_endothelial_growth_factor in human gingival fibroblasts .
25737638	0	interleukin-6	31,44	visfatin	46,54	interleukin-6	visfatin	3569	10135	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effect of vitamin_D therapy on interleukin-6 , visfatin , and hyaluronic acid levels in chronic hepatitis_C Egyptian patients .
16635168	0	interleukin-6_and_tumor_necrosis_factor-alpha	20,65	Interleukin-1alpha	0,18	interleukin-6 and tumor necrosis factor-alpha	Interleukin-1alpha	3569;7124	3552	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Interleukin-1alpha , interleukin-6_and_tumor_necrosis_factor-alpha levels in children with sepsis and meningitis .
8982099	0	interleukin-6_and_tumor_necrosis_factor-alpha	137,182	gastrin-releasing_peptide	24,49	interleukin-6 and tumor necrosis factor-alpha	gastrin-releasing peptide	3569;7124	2922	Gene	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Differential effects of gastrin-releasing_peptide , neuropeptide_Y , somatostatin and vasoactive_intestinal_peptide on interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha production by whole blood cells from healthy young and old subjects .
9647504	0	interleukin-6_and_tumor_necrosis_factor-alpha	38,83	interleukin-1	23,36	interleukin-6 and tumor necrosis factor-alpha	interleukin-1	3569;7124	3552	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	In vitro production of interleukin-1 , interleukin-6_and_tumor_necrosis_factor-alpha by different blood cells in patients on intermittent peritoneal dialysis .
17013473	0	interleukin-6_and_tumor_necrosis_factor-alpha	45,90	interleukin-1_alpha	24,43	interleukin-6 and tumor necrosis factor-alpha	interleukin-1 alpha	3569;7124	3552	Gene	Gene	concentrations|appos|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of interleukin-1_alpha , interleukin-6_and_tumor_necrosis_factor-alpha in neonatal_sepsis and meningitis .
7880977	0	interleukin-6_and_tumor_necrosis_factor-alpha	46,91	interleukin-1_beta	26,44	interleukin-6 and tumor necrosis factor-alpha	interleukin-1 beta	3569;7124	3553	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Cellular localisations of interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha mRNA in a parasitic granulomatous_disease_of_the_liver , alveolar_echinococcosis .
8982099	0	interleukin-6_and_tumor_necrosis_factor-alpha	137,182	interleukin-1_beta	117,135	interleukin-6 and tumor necrosis factor-alpha	interleukin-1 beta	3569;7124	3553	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Differential effects of gastrin-releasing_peptide , neuropeptide_Y , somatostatin and vasoactive_intestinal_peptide on interleukin-1_beta , interleukin-6_and_tumor_necrosis_factor-alpha production by whole blood cells from healthy young and old subjects .
10946822	0	interleukin-6_and_tumor_necrosis_factor-alpha	28,73	interleukin-1beta	9,26	interleukin-6 and tumor necrosis factor-alpha	interleukin-1beta	3569;7124	3553	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Enhanced interleukin-1beta , interleukin-6_and_tumor_necrosis_factor-alpha production by LPS stimulated human monocytes isolated from HIV + patients .
12873794	0	interleukin-6_and_tumor_necrosis_factor-alpha	128,173	interleukin-1beta	109,126	interleukin-6 and tumor necrosis factor-alpha	interleukin-1beta	3569;7124	3553	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Effect of calcitonin gene-related peptide , neuropeptide_Y , substance_P , and vasoactive_intestinal_peptide on interleukin-1beta , interleukin-6_and_tumor_necrosis_factor-alpha production by peripheral whole blood cells from rheumatoid_arthritis and osteoarthritis patients .
25846075	0	interleukin-6_receptor	68,90	A_disintegrin_and_metalloprotease_17	102,138	interleukin-6 receptor	A disintegrin and metalloprotease 17	3570	6868	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Secreted_Frizzled-related_protein_3 -LRB- sFRP3 -RRB- - mediated suppression of interleukin-6_receptor release by A_disintegrin_and_metalloprotease_17 -LRB- ADAM17 -RRB- is abrogated in the osteoarthritis-associated rare double variant of sFRP3 .
25846075	0	interleukin-6_receptor	68,90	A_disintegrin_and_metalloprotease_17	102,138	interleukin-6 receptor	A disintegrin and metalloprotease 17	3570	6868	Gene	Gene	release|amod|START_ENTITY release|nmod|END_ENTITY	Secreted_Frizzled-related_protein_3 -LRB- sFRP3 -RRB- - mediated suppression of interleukin-6_receptor release by A_disintegrin_and_metalloprotease_17 -LRB- ADAM17 -RRB- is abrogated in the osteoarthritis-associated rare double variant of sFRP3 .
10397166	0	interleukin-6_receptor	26,48	IL-6R	50,55	interleukin-6 receptor	IL-6R	3570	3570	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Generation of ` truncated ' interleukin-6_receptor -LRB- IL-6R -RRB- mRNA by alternative splicing ; a possible source of soluble IL-6R .
16056242	0	interleukin-6_receptor	22,44	Interleukin-6	0,13	interleukin-6 receptor	Interleukin-6	24499(Tax:10116)	24498(Tax:10116)	Gene	Gene	complex|amod|START_ENTITY reduces|nsubj|complex END_ENTITY|parataxis|reduces	Interleukin-6 / soluble interleukin-6_receptor complex reduces infarct size via inhibiting myocardial_apoptosis .
16690760	0	interleukin-6_receptor	104,126	Interleukin-6	0,13	interleukin-6 receptor	Interleukin-6	3570	3569	Gene	Gene	limited|nmod|START_ENTITY limited|nsubjpass|signalling signalling|amod|END_ENTITY	Interleukin-6 signalling in juvenile_idiopathic_arthritis is limited by proteolytically cleaved soluble interleukin-6_receptor .
18980999	0	interleukin-6_receptor	26,48	Interleukin-6	0,13	interleukin-6 receptor	Interleukin-6	3570	3569	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Interleukin-6 and soluble interleukin-6_receptor levels as markers of disease extent and prognosis in neuroblastoma .
22591418	0	interleukin-6_receptor	14,36	Interleukin-6	0,13	interleukin-6 receptor	Interleukin-6	3570	3569	Gene	Gene	pathway|amod|START_ENTITY target|nsubj|pathway END_ENTITY|parataxis|target	Interleukin-6 / interleukin-6_receptor pathway as a new therapy target in epithelial_ovarian_cancer .
24695006	0	interleukin-6_receptor	26,48	Interleukin-6	0,13	interleukin-6 receptor	Interleukin-6	3570	3569	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Interleukin-6 and soluble interleukin-6_receptor levels in posttraumatic_stress_disorder : associations with lifetime diagnostic status and psychological context .
24702712	0	interleukin-6_receptor	38,60	Interleukin-6	0,13	interleukin-6 receptor	Interleukin-6	3570	3569	Gene	Gene	glucose|amod|START_ENTITY combination|nmod|glucose END_ENTITY|nmod|combination	Interleukin-6 in combination with the interleukin-6_receptor stimulates glucose uptake in resting human skeletal muscle independently of insulin action .
26725994	0	interleukin-6_receptor	15,37	Interleukin-6	0,13	interleukin-6 receptor	Interleukin-6	3570	3569	Gene	Gene	dementia|amod|START_ENTITY END_ENTITY|appos|dementia	Interleukin-6 , interleukin-6_receptor gene variant , small-vessel_disease and incident dementia .
16432158	0	interleukin-6_receptor	91,113	MEK	180,183	interleukin-6 receptor	MEK	3570	5609	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6_receptor and epidermal_growth_factor_receptor signaling through JAK and/or MEK in head_and_neck_squamous_cell_carcinomas .
16557588	0	interleukin-6_receptor	61,83	Tax	35,38	interleukin-6 receptor	Tax	3570	6900	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Human_T-cell_leukemia_virus_type-I Tax induces expression of interleukin-6_receptor -LRB- IL-6R -RRB- : Shedding of soluble IL-6R and activation of STAT3 signaling .
10633884	0	interleukin-6_receptor	16,38	interleukin-6	74,87	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|fibroblasts fibroblasts|amod|gingival gingival|amod|END_ENTITY	Role of soluble interleukin-6_receptor in inflamed gingiva for binding of interleukin-6 to gingival fibroblasts .
11504839	0	interleukin-6_receptor	29,51	interleukin-6	14,27	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	gp80|amod|START_ENTITY gp80|amod|END_ENTITY	Expression of interleukin-6 , interleukin-6_receptor -LRB- gp80 -RRB- , and the receptor 's signal-transducing subunit -LRB- gp130 -RRB- in human normal pituitary glands and pituitary_adenomas .
12664314	0	interleukin-6_receptor	126,148	interleukin-6	61,74	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	levels|amod|START_ENTITY increase|nmod|levels magnitude|nmod|increase determine|dobj|magnitude determine|nsubj|Polymorphisms Polymorphisms|nmod|gene gene|acl|encoding encoding|dobj|END_ENTITY	Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6_receptor levels in Alzheimer 's _ disease .
14557255	0	interleukin-6_receptor	65,87	interleukin-6	28,41	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	spectroscopy|amod|START_ENTITY epitope|nmod|spectroscopy epitope|amod|END_ENTITY	Direct determination of the interleukin-6 binding epitope of the interleukin-6_receptor by NMR spectroscopy .
15129368	0	interleukin-6_receptor	26,48	interleukin-6	4,17	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	system|amod|START_ENTITY system|dep|END_ENTITY	The interleukin-6 / soluble interleukin-6_receptor system induces parathyroid_hormone-related_protein in human osteoblastic cells .
16096463	0	interleukin-6_receptor	37,59	interleukin-6	15,28	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	axis|amod|START_ENTITY Changes|dep|axis Changes|nmod|END_ENTITY	Changes in the interleukin-6 / soluble interleukin-6_receptor axis in meningococcal septic_shock .
16512982	0	interleukin-6_receptor	24,46	interleukin-6	10,23	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	stimulation|amod|START_ENTITY stimulation|dep|END_ENTITY	Autocrine interleukin-6 / interleukin-6_receptor stimulation in non-small-cell_lung_cancer .
17549633	0	interleukin-6_receptor	29,51	interleukin-6	6,19	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	START_ENTITY|amod|soluble soluble|amod|END_ENTITY	Serum interleukin-6 , soluble interleukin-6_receptor and Crohn 's _ disease activity .
17978466	0	interleukin-6_receptor	137,159	interleukin-6	44,57	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	antibody|amod|START_ENTITY tocilizumab|dep|antibody drug|appos|tocilizumab advances|dep|drug advances|nmod|immunopathophysiology immunopathophysiology|nmod|END_ENTITY	Recent advances in immunopathophysiology of interleukin-6 : an innovative therapeutic drug , tocilizumab -LRB- recombinant humanized anti-human interleukin-6_receptor antibody -RRB- , unveils the mysterious etiology of immune-mediated inflammatory diseases .
19264784	0	interleukin-6_receptor	111,133	interleukin-6	17,30	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	pathways|nmod|START_ENTITY pathways|csubj|Unraveling Unraveling|dobj|binding binding|amod|END_ENTITY	Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6_receptor .
20396982	0	interleukin-6_receptor	42,64	interleukin-6	16,29	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	The response of interleukin-6 and soluble interleukin-6_receptor isoforms following intermittent high intensity and continuous moderate intensity cycling .
23172750	0	interleukin-6_receptor	82,104	interleukin-6	47,60	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	inhibition|amod|START_ENTITY blocking|nmod|inhibition blocking|dobj|effects effects|acl|END_ENTITY	Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6_receptor inhibition in rheumatoid_arthritis and other inflammatory conditions .
25151086	0	interleukin-6_receptor	55,77	interleukin-6	33,46	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	induced-secretion|amod|START_ENTITY suppresses|dep|induced-secretion suppresses|dep|END_ENTITY	Synthetic -LRB- + -RRB- - terrein suppresses interleukin-6 / soluble interleukin-6_receptor induced-secretion of vascular_endothelial_growth_factor in human gingival fibroblasts .
25245339	0	interleukin-6_receptor	23,45	interleukin-6	46,59	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	Interleukin-6|amod|START_ENTITY Interleukin-6|dep|complex complex|amod|END_ENTITY	Interleukin-6 , soluble interleukin-6_receptor / interleukin-6 complex and insulin resistance in obese children and adolescents .
25856562	0	interleukin-6_receptor	42,64	interleukin-6	21,34	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	IL-6R|amod|START_ENTITY /|dobj|IL-6R /|nsubj|effects effects|nmod|END_ENTITY	Antitumor effects of interleukin-6 -LRB- IL-6 -RRB- / interleukin-6_receptor -LRB- IL-6R -RRB- signaling pathway inhibition in clear_cell_carcinoma_of_the_ovary .
7674091	0	interleukin-6_receptor	40,62	interleukin-6	14,27	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	The effect of interleukin-6 and soluble interleukin-6_receptor protein on the bone resorptive activity of human osteoclasts generated in vitro .
7713920	0	interleukin-6_receptor	96,118	interleukin-6	33,46	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	antagonist|amod|START_ENTITY affect|nmod|antagonist affect|dep|Combining Combining|dobj|mutations mutations|nmod|END_ENTITY	Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6_receptor antagonist on human myeloma cells .
8083235	0	interleukin-6_receptor	14,36	interleukin-6	96,109	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	High|amod|START_ENTITY complex|nsubj|High complex|acl|consisting consisting|advcl|END_ENTITY	High affinity interleukin-6_receptor is a hexameric complex consisting of two molecules each of interleukin-6 , interleukin-6_receptor , and gp-130 .
8200444	0	interleukin-6_receptor	14,36	interleukin-6	51,64	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of interleukin-6_receptor expression by interleukin-6 in human monocytes -- a re-examination .
8392518	1	interleukin-6_receptor	216,238	interleukin-6	147,160	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	different|nmod|START_ENTITY receptor|amod|different acts|nmod|receptor acts|nsubj|Evidence Evidence|amod|END_ENTITY	Evidence that interleukin-6 possibly acts via a receptor different from the 80-kDa interleukin-6_receptor .
8420983	0	interleukin-6_receptor	68,90	interleukin-6	22,35	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	system|amod|START_ENTITY component|nmod|system association|nmod|component association|nmod|END_ENTITY	Direct association of interleukin-6 with a 130-kDa component of the interleukin-6_receptor system .
8651752	0	interleukin-6_receptor	38,60	interleukin-6	105,118	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression facilitates|nsubj|induction facilitates|dobj|stimulation stimulation|amod|END_ENTITY	Glucocorticoid-dependent induction of interleukin-6_receptor expression in human hepatocytes facilitates interleukin-6 stimulation of amino_acid transport .
9615791	0	interleukin-6_receptor	58,80	interleukin-6	84,97	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	blocking|nmod|START_ENTITY blocking|advcl|END_ENTITY	In vivo blocking effects of a humanized antibody to human interleukin-6_receptor on interleukin-6 function in primates .
9645958	0	interleukin-6_receptor	90,112	interleukin-6	113,126	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	transcription|nmod|START_ENTITY complex|dep|transcription complex|amod|END_ENTITY	Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6_receptor / interleukin-6 complex .
9867112	0	interleukin-6_receptor	32,54	interleukin-6	10,23	interleukin-6 receptor	interleukin-6	3570	3569	Gene	Gene	expression|amod|START_ENTITY levels|appos|expression levels|amod|END_ENTITY	Increased interleukin-6 levels , interleukin-6_receptor and gp130 expression in peripheral lymphocytes of patients with inflammatory_bowel_disease .
22728771	0	interleukin-7	127,140	Bim	22,25	interleukin-7	Bim	3574	10018	Gene	Gene	lymphocytes|amod|START_ENTITY govern|nmod|lymphocytes activities|acl:relcl|govern contribute|nmod|activities contribute|nsubj|isoforms isoforms|nmod|END_ENTITY	The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes .
9420139	0	interleukin-7	15,28	CD23	132,136	interleukin-7	CD23	3574	2208	Gene	Gene	molecules|amod|START_ENTITY role|nmod|molecules role|nmod|subset subset|compound|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
21214539	0	interleukin-7	138,151	CD27	94,98	interleukin-7	CD27	3574	939	Gene	Gene	involvement|nmod|START_ENTITY cells|dep|involvement cells|compound|END_ENTITY	Cytomegalovirus_infection induces the accumulation of short-lived , multifunctional CD4 + CD45RA + CD27 + T cells : the potential involvement of interleukin-7 in this process .
16406844	0	interleukin-7	96,109	CD28	90,94	interleukin-7	CD28	3574	940	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Ex vivo expansion of dendritic-cell-activated antigen-specific CD4 + T cells with anti-CD3 / CD28 , interleukin-7 , and interleukin-15 : potential for adoptive T cell immunotherapy .
10583600	0	interleukin-7	18,31	CD4	78,81	interleukin-7	CD4	3574	920	Gene	Gene	START_ENTITY|nmod|maintenance maintenance|nmod|T-cell T-cell|compound|END_ENTITY	Putative role for interleukin-7 in the maintenance of the recirculating naive CD4 + T-cell pool .
12719571	0	interleukin-7	57,70	CD4	74,77	interleukin-7	CD4	3574	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Positive regulation of CXCR4 expression and signaling by interleukin-7 in CD4 + mature thymocytes correlates with their capacity to favor human_immunodeficiency_X4_virus replication .
15331707	0	interleukin-7	12,25	CD4	65,68	interleukin-7	CD4	16196(Tax:10090)	12504(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|proliferation proliferation|nmod|+ +|compound|END_ENTITY	Recombinant interleukin-7 induces proliferation of naive macaque CD4 + and CD8 + T cells in vivo .
15934068	0	interleukin-7	25,38	CD4	120,123	interleukin-7	CD4	3574	920	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activation activation|nmod|cells cells|amod|END_ENTITY	Increased intraarticular interleukin-7 in rheumatoid_arthritis patients stimulates cell contact-dependent activation of CD4 -LRB- + -RRB- T cells and macrophages .
16406844	0	interleukin-7	96,109	CD4	63,66	interleukin-7	CD4	3574	920	Gene	Gene	cells|amod|START_ENTITY cells|compound|END_ENTITY	Ex vivo expansion of dendritic-cell-activated antigen-specific CD4 + T cells with anti-CD3 / CD28 , interleukin-7 , and interleukin-15 : potential for adoptive T cell immunotherapy .
21214539	0	interleukin-7	138,151	CD4	83,86	interleukin-7	CD4	3574	920	Gene	Gene	involvement|nmod|START_ENTITY cells|dep|involvement cells|compound|END_ENTITY	Cytomegalovirus_infection induces the accumulation of short-lived , multifunctional CD4 + CD45RA + CD27 + T cells : the potential involvement of interleukin-7 in this process .
25784743	0	interleukin-7	46,59	CD4	22,25	interleukin-7	CD4	3574	920	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|responses responses|compound|END_ENTITY	Interferon-a inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling .
25784743	0	interleukin-7	46,59	CD4	22,25	interleukin-7	CD4	3574	920	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|responses responses|compound|END_ENTITY	Interferon-a inhibits CD4 T cell responses to interleukin-7 and interleukin-2 and selectively interferes with Akt signaling .
26675348	0	interleukin-7	18,31	CD4	42,45	interleukin-7	CD4	3574	920	Gene	Gene	increases|amod|START_ENTITY Administration|nmod|increases END_ENTITY|nsubj|Administration	Administration of interleukin-7 increases CD4 T cells in idiopathic CD4_lymphocytopenia .
7507711	0	interleukin-7	7,20	CD4	71,74	interleukin-7	CD4	3574	920	Gene	Gene	START_ENTITY|acl|propagate propagate|dobj|cells cells|nummod|END_ENTITY	Use of interleukin-7 , interleukin-2 , and interferon-gamma to propagate CD4 + T cells in culture with maintained antigen specificity .
7871393	0	interleukin-7	42,55	CD4	76,79	interleukin-7	CD4	3574	920	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Differential effects of interleukin-2 and interleukin-7 on the induction of CD4 and CD8 expression by double-negative human thymocytes .
9420139	0	interleukin-7	15,28	CD4	127,130	interleukin-7	CD4	3574	920	Gene	Gene	molecules|amod|START_ENTITY role|nmod|molecules role|nmod|subset subset|compound|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
22529903	0	interleukin-7	40,53	CD8	62,65	interleukin-7	CD8	3574	925	Gene	Gene	growth|amod|START_ENTITY growth|compound|END_ENTITY	Exogenous amino_acids are essential for interleukin-7 induced CD8 T cell growth .
2804342	0	interleukin-7	43,56	IL-7	58,62	interleukin-7	IL-7	16196(Tax:10090)	16196(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	A stimulatory effect of recombinant murine interleukin-7 -LRB- IL-7 -RRB- on B-cell colony formation and an inhibitory effect of IL-1_alpha .
9420139	0	interleukin-7	15,28	LFA-1	49,54	interleukin-7	LFA-1	3574	3683	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	A new role for interleukin-7 in the induction of LFA-1 and VLA-4 adhesion molecules in Phorbol_12myristate_13acetate activated CD4 + CD23 + T-cell subset .
10078962	0	interleukin-7	113,126	interferon-gamma	95,111	interleukin-7	interferon-gamma	25647(Tax:10116)	25712(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma , interleukin-7 , or B7-1-transfected tumor cells .
9743616	0	interleukin-7_and_transforming_growth_factor-beta	84,133	IL-4	31,35	interleukin-7 and transforming growth factor-beta	IL-4	3574;7040	3565	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of human lymphocyte IL-4 secretion by intestinal epithelial cell-derived interleukin-7_and_transforming_growth_factor-beta .
22865857	0	interleukin-7_receptor	35,57	Gfi1	102,106	interleukin-7 receptor	Gfi1	16197(Tax:10090)	14581(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	CD8 lineage-specific regulation of interleukin-7_receptor expression by the transcriptional repressor Gfi1 .
16537621	0	interleukin-7_receptor_alpha_chain	18,52	CD8	79,82	interleukin-7 receptor alpha chain	CD8	16197(Tax:10090)	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Expression of the interleukin-7_receptor_alpha_chain -LRB- CD127 -RRB- on virus-specific CD8 + T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis_B_virus infection .
12003967	0	interleukin-8	53,66	AP-1	105,109	interleukin-8	AP-1	3576	3726	Gene	Gene	production|amod|START_ENTITY lipopolysaccharide-induced|dobj|production lipopolysaccharide-induced|nmod|factors factors|amod|END_ENTITY	Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa_B transcription factors .
18692129	0	interleukin-8	50,63	AP-1	78,82	interleukin-8	AP-1	3576	3727	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Superoxide_dismutase attenuates hyperoxia-induced interleukin-8 induction via AP-1 .
16269654	0	interleukin-8	46,59	Adiponectin	0,11	interleukin-8	Adiponectin	3576	9370	Gene	Gene	synthesis|nmod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Adiponectin inhibits endothelial synthesis of interleukin-8 .
12588890	0	interleukin-8	19,32	Albumin	0,7	interleukin-8	Albumin	3576	213	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo .
9893038	0	interleukin-8	22,35	Bradykinin	0,10	interleukin-8	Bradykinin	3576	3827	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Bradykinin stimulates interleukin-8 production by human lung fibroblasts .
10476751	0	interleukin-8	61,74	C-reactive_protein	76,94	interleukin-8	C-reactive protein	3576	1401	Gene	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Assessment of measuring circulating levels of interleukin-6 , interleukin-8 , C-reactive_protein , soluble Fc gamma receptor type III , and mannose-binding_protein in febrile children with cancer and neutropenia .
16123332	0	interleukin-8	58,71	C-reactive_protein	31,49	interleukin-8	C-reactive protein	3576	1401	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|Loss Loss|nmod|symmetry symmetry|nmod|END_ENTITY	Loss of pentameric symmetry in C-reactive_protein induces interleukin-8 secretion through peroxynitrite signaling in human neutrophils .
16220077	0	interleukin-8	28,41	C-reactive_protein	0,18	interleukin-8	C-reactive protein	3576	1401	Gene	Gene	secretion|amod|START_ENTITY augments|dobj|secretion augments|nsubj|END_ENTITY	C-reactive_protein augments interleukin-8 secretion in human peripheral blood monocytes .
19781372	0	interleukin-8	29,42	C-reactive_protein	0,18	interleukin-8	C-reactive protein	3576	1401	Gene	Gene	production|amod|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	C-reactive_protein decreases interleukin-8 production in human endothelial progenitor cells by inhibition of p38 MAPK pathway .
20188089	0	interleukin-8	13,26	C-reactive_protein	68,86	interleukin-8	C-reactive protein	3576	1401	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of interleukin-8 gene expression and protein secretion by C-reactive_protein in ARPE-19 cells .
23124693	0	interleukin-8	139,152	C-reactive_protein	32,50	interleukin-8	C-reactive protein	3576	1401	Gene	Gene	rate|amod|START_ENTITY index|appos|rate correlate|nmod|index correlate|nsubj|levels levels|amod|END_ENTITY	Elevated serum high-sensitivity C-reactive_protein levels in fibromyalgia_syndrome patients correlate with body mass index , interleukin-6 , interleukin-8 , erythrocyte sedimentation rate .
9712784	0	interleukin-8	30,43	C3a	15,18	interleukin-8	C3a	3576	718	Gene	Gene	secretion|amod|START_ENTITY Involvement|nmod|secretion Involvement|nmod|END_ENTITY	Involvement of C3a and C5a in interleukin-8 secretion by human polymorphonuclear cells in response to capsular material of Cryptococcus_neoformans .
11321363	0	interleukin-8	27,40	C5a	11,14	interleukin-8	C5a	3576	728	Gene	Gene	production|amod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of C5a and FMLP on interleukin-8 production and proliferation of human umbilical vein endothelial cells .
11854210	0	interleukin-8	87,100	CD14	15,19	interleukin-8	CD14	3576	929	Gene	Gene	production|nmod|START_ENTITY primed|nmod|production fibroblasts|xcomp|primed fibroblasts|nsubj|END_ENTITY	Human gingival CD14 -LRB- + -RRB- fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression .
11854210	0	interleukin-8	87,100	CD14	169,173	interleukin-8	CD14	3576	929	Gene	Gene	production|nmod|START_ENTITY production|acl|lipopolysaccharide lipopolysaccharide|nmod|up-regulation up-regulation|nmod|END_ENTITY	Human gingival CD14 -LRB- + -RRB- fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression .
12011031	0	interleukin-8	179,192	CD14	15,19	interleukin-8	CD14	3576	929	Gene	Gene	production|amod|START_ENTITY down-regulation|nmod|production leading|nmod|down-regulation Porphyromonas_gingivalis|acl|leading proteinases|nmod|Porphyromonas_gingivalis proteinases|nsubj|Proteolysis Proteolysis|nmod|END_ENTITY	Proteolysis of CD14 on human_gingival_fibroblasts by arginine-specific cysteine proteinases from Porphyromonas_gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production .
12831455	0	interleukin-8	75,88	CD14	166,170	interleukin-8	CD14	3576	929	Gene	Gene	production|amod|START_ENTITY inducing|dobj|production lipopolysaccharide|acl|inducing effects|nmod|lipopolysaccharide accompanied|nsubjpass|effects accompanied|nmod|up-regulation up-regulation|nmod|expression expression|amod|END_ENTITY	Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14 , Toll-like_receptor_4 , MD-2 and MyD88 expression .
14500479	0	interleukin-8	114,127	CD14	149,153	interleukin-8	CD14	3576	929	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Augmentation of Actinobacillus_actinomycetemcomitans invasion of human oral epithelial cells and up-regulation of interleukin-8 production by saliva CD14 .
15358661	0	interleukin-8	53,66	CD14	18,22	interleukin-8	CD14	3576	929	Gene	Gene	induction|nmod|START_ENTITY important|nmod|induction important|nsubj|END_ENTITY	Membrane-anchored CD14 is important for induction of interleukin-8 by lipopolysaccharide and peptidoglycan in uroepithelial cells .
17093102	0	interleukin-8	89,102	CD14	38,42	interleukin-8	CD14	3576	929	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|Binding Binding|nmod|glucuronoxylomannan glucuronoxylomannan|nmod|receptor receptor|compound|END_ENTITY	Binding of glucuronoxylomannan to the CD14 receptor in human A549 alveolar cells induces interleukin-8 production .
9632564	0	interleukin-8	111,124	CD14	40,44	interleukin-8	CD14	3576	929	Gene	Gene	secretion|amod|START_ENTITY expression|dep|secretion expression|nmod|END_ENTITY	Heterogeneous expression and release of CD14 by human_gingival_fibroblasts : characterization and CD14-mediated interleukin-8 secretion in response to lipopolysaccharide .
9784544	0	interleukin-8	79,92	CD14	48,52	interleukin-8	CD14	3576	929	Gene	Gene	release|acl|START_ENTITY release|compound|END_ENTITY	Helicobacter_pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8 , epithelial_neutrophil-activating_peptide_78 , and monocyte_chemotactic_protein_1 by human monocytes .
15556942	0	interleukin-8	22,35	CD38	14,18	interleukin-8	CD38	3576	952	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Activation of CD38 by interleukin-8 signaling regulates intracellular Ca2 + level and motility of lymphokine-activated killer cells .
16387844	0	interleukin-8	33,46	CXCL-8	48,54	interleukin-8	CXCL-8	3576	3576	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of human neutrophil interleukin-8 -LRB- CXCL-8 -RRB- to organelle -LRB- s -RRB- distinct from the classical granules and secretory vesicles .
12618418	0	interleukin-8	28,41	CXCL8	42,47	interleukin-8	CXCL8	3576	3576	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Pathophysiological roles of interleukin-8 / CXCL8 in pulmonary_diseases .
15801837	0	interleukin-8	43,56	CXCL8	58,63	interleukin-8	CXCL8	3576	3576	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Predicting human serum albumin affinity of interleukin-8 -LRB- CXCL8 -RRB- inhibitors by 3D-QSPR approach .
16556047	0	interleukin-8	21,34	CXCL8	35,40	interleukin-8	CXCL8	3576	3576	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Mitogenic effects of interleukin-8 / CXCL8 on cancer cells .
9373270	0	interleukin-8	136,149	CXCR-1	160,166	interleukin-8	CXCR-1	3576	3577	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The CXC-chemokine neutrophil-activating_peptide-2 induces two distinct optima of neutrophil chemotaxis by differential interaction with interleukin-8 receptors CXCR-1 and CXCR-2 .
11113872	0	interleukin-8	20,33	CXCR1	45,50	interleukin-8	CXCR1	3576	3577	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Distribution of the interleukin-8 receptors , CXCR1 and CXCR2 , in inflamed gut tissue .
15252057	0	interleukin-8	36,49	CXCR1	68,73	interleukin-8	CXCR1	3576	3577	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|binding binding|nmod|END_ENTITY	Dimer_dissociation is essential for interleukin-8 -LRB- IL-8 -RRB- binding to CXCR1 receptor .
15652230	0	interleukin-8	14,27	CXCR1	109,114	interleukin-8	CXCR1	3576	3577	Gene	Gene	responses|amod|START_ENTITY Inhibition|nmod|responses Inhibition|nmod|repertaxin repertaxin|appos|inhibitor inhibitor|nmod|END_ENTITY	Inhibition of interleukin-8 -LRB- CXCL8/IL -8 -RRB- responses by repertaxin , a new inhibitor of the chemokine receptors CXCR1 and CXCR2 .
17222184	0	interleukin-8	34,47	CXCR1	67,72	interleukin-8	CXCR1	3576	3577	Gene	Gene	monomer|amod|START_ENTITY characterization|nmod|monomer characterization|amod|binding binding|nmod|domain domain|compound|END_ENTITY	Thermodynamic characterization of interleukin-8 monomer binding to CXCR1 receptor N-terminal domain .
19681642	0	interleukin-8	49,62	CXCR1	88,93	interleukin-8	CXCR1	3576	3577	Gene	Gene	monomer|amod|START_ENTITY monomer|nmod|N-domain N-domain|compound|END_ENTITY	Structural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain : role of coupled interactions and dynamics .
22019593	0	interleukin-8	16,29	CXCR1	64,69	interleukin-8	CXCR1	3576	3577	Gene	Gene	receptor|amod|START_ENTITY Interactions|nmod|receptor END_ENTITY|nsubj|Interactions	Interactions of interleukin-8 with the human chemokine receptor CXCR1 in phospholipid bilayers by NMR spectroscopy .
24164922	0	interleukin-8	23,36	CXCR1	119,124	interleukin-8	CXCR1	3576	3577	Gene	Gene	mediates|amod|START_ENTITY secretion|nmod|mediates autocrine|nsubj|secretion autocrine|xcomp|signalling signalling|nmod|cells cells|nmod|END_ENTITY	Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1 .
9885232	0	interleukin-8	21,34	CXCR1	74,79	interleukin-8	CXCR1	3576	3577	Gene	Gene	role|nmod|START_ENTITY role|dep|analysis analysis|nmod|END_ENTITY	The biologic role of interleukin-8 : functional analysis and expression of CXCR1 and CXCR2 on human eosinophils .
11180010	0	interleukin-8	137,150	CXCR2	151,156	interleukin-8	CXCR2	3576	3579	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Response of psoriasis to interleukin-10 is associated with suppression of cutaneous type 1 inflammation , downregulation of the epidermal interleukin-8 / CXCR2 pathway and normalization of keratinocyte maturation .
12628493	0	interleukin-8	50,63	CXCR2	166,171	interleukin-8	CXCR2	3576	3579	Gene	Gene	interactions|nmod|START_ENTITY Characterization|nmod|interactions Characterization|nmod|END_ENTITY	Characterization of the molecular interactions of interleukin-8 -LRB- CXCL8 -RRB- , growth related oncogen alpha -LRB- CXCL1 -RRB- and a non-peptide antagonist -LRB- SB_225002 -RRB- with the human CXCR2 .
17030560	0	interleukin-8	17,30	CXCR2	41,46	interleukin-8	CXCR2	3576	3579	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Exercise induces interleukin-8 receptor -LRB- CXCR2 -RRB- expression in human skeletal muscle .
23029099	0	interleukin-8	27,40	CXCR2	89,94	interleukin-8	CXCR2	3576	3579	Gene	Gene	Glioblastoma|amod|START_ENTITY induces|nsubj|Glioblastoma induces|dobj|permeability permeability|nmod|END_ENTITY	Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2 .
17007741	0	interleukin-8	67,80	Calcitonin_gene-related_peptide	0,31	interleukin-8	Calcitonin gene-related peptide	3576	796	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Calcitonin_gene-related_peptide inhibits interleukin-1beta-induced interleukin-8 secretion in human type II alveolar epithelial cells .
12958044	0	interleukin-8	23,36	Cyclosporin_A	0,13	interleukin-8	Cyclosporin A	3576	1161	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Cyclosporin_A enhances interleukin-8 expression by inducing activator_protein-1 in human aortic smooth muscle cells .
9349985	0	interleukin-8	24,37	Cyclosporine_A	0,14	interleukin-8	Cyclosporine A	3576	1161	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Cyclosporine_A inhibits interleukin-8 production in a human colon epithelial cell line -LRB- HT-29 -RRB- .
20199879	0	interleukin-8	10,23	Duffy_antigen_receptor_for_chemokines	111,148	interleukin-8	Duffy antigen receptor for chemokines	3576	2532	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|role role|nmod|END_ENTITY	Effect of interleukin-8 and RANTES on the Gardos channel activity in sickle human red blood cells : role of the Duffy_antigen_receptor_for_chemokines .
21932060	0	interleukin-8	54,67	EGFR	83,87	interleukin-8	EGFR	3576	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells .
16697690	0	interleukin-8	13,26	ERK1/2	55,61	interleukin-8	ERK1/2	3576	5595;5594	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Induction of interleukin-8 secretion and activation of ERK1/2 , p38 MAPK signaling pathways by thrombin in dermal fibroblasts .
9787140	0	interleukin-8	69,82	Endothelin-1	0,12	interleukin-8	Endothelin-1	3576	1906	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Endothelin-1 induces production of the neutrophil chemotactic factor interleukin-8 by human brain-derived endothelial cells .
16678783	0	interleukin-8	49,62	Epidermal_growth_factor	0,23	interleukin-8	Epidermal growth factor	3576	1950	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Epidermal_growth_factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1beta .
16552751	0	interleukin-8	19,32	Ghrelin	0,7	interleukin-8	Ghrelin	3576	58991(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells .
19184985	0	interleukin-8	49,62	Hepatocyte_growth_factor	0,24	interleukin-8	Hepatocyte growth factor	3576	3082	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Hepatocyte_growth_factor induces hypoxia-related interleukin-8 expression in lung_adenocarcinoma cells .
23268406	0	interleukin-8	75,88	High-mobility_group_box_protein_1	1,34	interleukin-8	High-mobility group box protein 1	3576	3146	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	-LSB- High-mobility_group_box_protein_1 in synergy with interleukin-1b promotes interleukin-8 expression in human airway epithelial cells in vitro -RSB- .
7922784	0	interleukin-8	56,69	IL-1_beta	24,33	interleukin-8	IL-1 beta	3576	3553	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Dexamethasone regulates IL-1_beta and TNF-alpha-induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells .
10086655	0	interleukin-8	10,23	IL-8	125,129	interleukin-8	IL-8	3576	3576	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Increased interleukin-8 -LRB- IL-8 -RRB- in rectal dialysate from patients with ulcerative_colitis : evidence for a biological role for IL-8 in inflammation of the colon .
10853906	0	interleukin-8	10,23	IL-8	25,29	interleukin-8	IL-8	3576	3576	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Increased interleukin-8 -LRB- IL-8 -RRB- expression is related to aseptic_loosening_of_total_hip_replacement .
12561382	0	interleukin-8	18,31	IL-8	33,37	interleukin-8	IL-8	3576	3576	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- The study on the interleukin-8 -LRB- IL-8 -RRB- -RSB- .
12781210	0	interleukin-8	47,60	IL-8	62,66	interleukin-8	IL-8	3576	3576	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of interleukin-1alpha -LRB- IL-1alpha -RRB- and interleukin-8 -LRB- IL-8 -RRB- expression and release in in vitro reconstructed human epidermis for the prediction of in vivo skin irritation and/or sensitization .
16739069	0	interleukin-8	26,39	IL-8	41,45	interleukin-8	IL-8	3576	3576	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Green tea extract induces interleukin-8 -LRB- IL-8 -RRB- mRNA and protein expression but specifically inhibits IL-8 secretion in caco-2 cells .
16819095	0	interleukin-8	54,67	IL-8	69,73	interleukin-8	IL-8	3576	3576	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ozone enhances diesel exhaust particles -LRB- DEP -RRB- - induced interleukin-8 -LRB- IL-8 -RRB- gene expression in human airway epithelial cells through activation of nuclear factors - kappaB -LRB- NF-kappaB -RRB- and IL-6 -LRB- NF-IL6 -RRB- .
19095436	0	interleukin-8	24,37	IL-8	39,43	interleukin-8	IL-8	3576	3576	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The predictive value of interleukin-8 -LRB- IL-8 -RRB- in hospitalised patients with fever and chemotherapy-induced neutropenia .
1932367	0	interleukin-8	13,26	IL-8	28,32	interleukin-8	IL-8	3576	3576	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Elevation of interleukin-8 -LRB- IL-8 -RRB- levels in joint fluids of patients with rheumatoid_arthritis and the induction by IL-8 of leukocyte infiltration and synovitis in rabbit_joints .
21530580	0	interleukin-8	57,70	IL-8	72,76	interleukin-8	IL-8	100036815(Tax:8355)	100036815(Tax:8355)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Molecular cloning , expression and functional analysis of interleukin-8 -LRB- IL-8 -RRB- in South African clawed_frog -LRB- Xenopus_laevis -RRB- .
22244449	0	interleukin-8	32,45	IL-8	47,51	interleukin-8	IL-8	3576	3576	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	An immunohistochemical study of interleukin-8 -LRB- IL-8 -RRB- in breast_cancer .
22293942	0	interleukin-8	103,116	IL-8	118,122	interleukin-8	IL-8	3576	3576	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Association of glutathione_S-transferase 1-1 polymorphisms -LRB- A140D and E208K -RRB- with the expression of interleukin-8 -LRB- IL-8 -RRB- , transforming_growth_factor_beta -LRB- TGF-b -RRB- , and apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- in humans chronically exposed to arsenic in drinking water .
24337575	0	interleukin-8	112,125	IL-8	127,131	interleukin-8	IL-8	3576	3576	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Proteasome inhibition increases recruitment of IkB_kinase_b -LRB- IKKb -RRB- , S536P-p65 , and transcription factor EGR1 to interleukin-8 -LRB- IL-8 -RRB- promoter , resulting in increased IL-8 production in ovarian_cancer cells .
7517209	0	interleukin-8	90,103	IL-8	105,109	interleukin-8	IL-8	3576	3576	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cytokine gene expression in B-cell_chronic_lymphocytic_leukemia : evidence of constitutive interleukin-8 -LRB- IL-8 -RRB- mRNA expression and secretion of biologically active IL-8 protein .
7518426	0	interleukin-8	18,31	IL-8	33,37	interleukin-8	IL-8	3576	100009129(Tax:9986)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The N terminus of interleukin-8 -LRB- IL-8 -RRB- receptor confers high affinity binding to human IL-8 .
7964163	0	interleukin-8	25,38	IL-8	40,44	interleukin-8	IL-8	3576	3576	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Essential involvement of interleukin-8 -LRB- IL-8 -RRB- in acute inflammation .
8246610	0	interleukin-8	27,40	IL-8	42,46	interleukin-8	IL-8	3576	3576	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Constitutive production of interleukin-8 -LRB- IL-8 -RRB- by normal and malignant human B-cells and other cell types .
8454590	0	interleukin-8	37,50	IL-8	52,56	interleukin-8	IL-8	3576	3576	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Modification of sulfhydryl groups of interleukin-8 -LRB- IL-8 -RRB- receptor impairs binding of IL-8 and IL-8-mediated chemotactic response of human polymorphonuclear neutrophils .
9125224	0	interleukin-8	53,66	IL-8	68,72	interleukin-8	IL-8	20309(Tax:10090)	20309(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Redox regulation of lipopolysaccharide -LRB- LPS -RRB- - induced interleukin-8 -LRB- IL-8 -RRB- gene expression mediated by NF kappa B and AP-1 in human astrocytoma U373 cells .
11254583	0	interleukin-8	147,160	IRAK	53,57	interleukin-8	IRAK	3576	3654	Gene	Gene	transcription|nmod|START_ENTITY induces|dobj|transcription activate|ccomp|induces activate|dobj|TLR2 TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
17304101	0	interleukin-8	101,114	Interferon-gamma	0,16	interleukin-8	Interferon-gamma	3576	3458	Gene	Gene	p70|dep|START_ENTITY secretion|amod|p70 enhancing|dobj|secretion neutrophils|acl|enhancing act|nmod|neutrophils act|nsubj|lipopolysaccharide lipopolysaccharide|amod|END_ENTITY	Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8 , interleukin-1beta , tumor_necrosis_factor-alpha , and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like_receptor_4 .
8286750	0	interleukin-8	29,42	Interferon-gamma	0,16	interleukin-8	Interferon-gamma	3576	3458	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interferon-gamma upregulates interleukin-8 gene expression in human monocytic cells by a posttranscriptional mechanism .
8473010	0	interleukin-8	26,39	Interferon-gamma	0,16	interleukin-8	Interferon-gamma	3576	3458	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits interleukin-8 production by human polymorphonuclear leucocytes .
7994038	0	interleukin-8	22,35	Interleukin-1	0,13	interleukin-8	Interleukin-1	3576	3552	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism .
12507912	0	interleukin-8	43,56	Interleukin-10	0,14	interleukin-8	Interleukin-10	3576	3586	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits elevated chemokine interleukin-8 and regulated on activation normal T cell expressed and secreted production in cystic_fibrosis bronchial epithelial cells by targeting the I -LRB- k -RRB- B kinase alpha/beta complex .
8167346	0	interleukin-8	24,37	Interleukin-10	0,14	interleukin-8	Interleukin-10	3576	3586	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits interleukin-8 production in human neutrophils .
10594681	0	interleukin-8	33,46	Interleukin-15	0,14	interleukin-8	Interleukin-15	3576	3600	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-15 strongly inhibits interleukin-8 and monocyte_chemoattractant_protein-1 production in human colonic epithelial cells .
11298325	0	interleukin-8	42,55	Interleukin-18	0,14	interleukin-8	Interleukin-18	3576	3606	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interleukin-18 enhances the production of interleukin-8 by eosinophils .
8915952	0	interleukin-8	21,34	Interleukin-1_alpha	0,19	interleukin-8	Interleukin-1 alpha	3576	3552	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Interleukin-1_alpha , interleukin-8 and interferon-alpha levels in gingival crevicular fluid .
10460756	0	interleukin-8	43,56	Interleukin-1_receptor_antagonist	0,33	interleukin-8	Interleukin-1 receptor antagonist	3576	3557	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-1_receptor_antagonist inhibits interleukin-8 expression in A549 respiratory epithelial cells infected in vitro with a replication-deficient recombinant adenovirus vector .
12089685	0	interleukin-8	29,42	Interleukin-1beta	0,17	interleukin-8	Interleukin-1beta	3576	3553	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-1beta stimulates interleukin-8 production and gene expression in synovial cells from human temporomandibular_joint .
8583820	0	interleukin-8	161,174	L-selectin	124,134	interleukin-8	L-selectin	3576	6402	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Effects of inhibition of complement activation using recombinant soluble complement receptor 1 on neutrophil CD11b/CD18 and L-selectin expression and release of interleukin-8 and elastase in simulated cardiopulmonary bypass .
7655023	0	interleukin-8	35,48	Leukemia_inhibitory_factor	0,26	interleukin-8	Leukemia inhibitory factor	3576	3976	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Leukemia_inhibitory_factor induces interleukin-8 and monocyte_chemotactic_and_activating_factor in human monocytes : differential regulation by interferon-gamma .
15069060	0	interleukin-8	40,53	MEK	0,3	interleukin-8	MEK	3576	5609	Gene	Gene	modulator|nmod|START_ENTITY modulator|nsubj|END_ENTITY	MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells .
23349885	0	interleukin-8	86,99	MMP-2	34,39	interleukin-8	MMP-2	3576	4313	Gene	Gene	inducing|xcomp|START_ENTITY up-regulates|advcl|inducing up-regulates|dobj|expression expression|amod|END_ENTITY	Human_papillomavirus up-regulates MMP-2 and MMP-9 expression and activity by inducing interleukin-8 in lung_adenocarcinomas .
9327744	0	interleukin-8	14,27	MMP-2	65,70	interleukin-8	MMP-2	3576	4313	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis .
11254583	0	interleukin-8	147,160	MyD88	45,50	interleukin-8	MyD88	3576	4615	Gene	Gene	transcription|nmod|START_ENTITY induces|dobj|transcription activate|ccomp|induces activate|dobj|TLR2 TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
11192539	0	interleukin-8	47,60	N-acetyl-L-cysteine	0,19	interleukin-8	N-acetyl-L-cysteine	3576	7504	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	N-acetyl-L-cysteine inhibits bleomycin-induced interleukin-8 secretion by bronchial epithelial cells .
2189453	0	interleukin-8	51,64	NAP-1	44,49	interleukin-8	NAP-1	3576	3576	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Neutrophil attractant/activation protein-1 -LRB- NAP-1 -LSB- interleukin-8 -RSB- -RRB- .
17366569	0	interleukin-8	130,143	NF-IL-6	41,48	interleukin-8	NF-IL-6	3576	1051	Gene	Gene	expression|amod|START_ENTITY crucial|nmod|expression crucial|nsubj|Activation Activation|nmod|IL-6 IL-6|appos|END_ENTITY	Activation of transcription factor IL-6 -LRB- NF-IL-6 -RRB- and nuclear factor-kappaB -LRB- NF-kappaB -RRB- by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells .
10505790	0	interleukin-8	23,36	NF-kappaB	92,101	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|advcl|inhibiting inhibiting|xcomp|binding binding|advmod|END_ENTITY	Nitric_oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-kappaB binding to DNA : effects on endothelial function .
10638705	0	interleukin-8	80,93	NF-kappaB	50,59	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Cooperation between transcription factor AP-1 and NF-kappaB in the induction of interleukin-8 in human pancreatic_adenocarcinoma cells by hypoxia .
10823417	0	interleukin-8	24,37	NF-kappaB	83,92	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	synthesis|amod|START_ENTITY up-regulates|dobj|synthesis up-regulates|nmod|mechanism mechanism|amod|END_ENTITY	Paclitaxel up-regulates interleukin-8 synthesis in human lung_carcinoma through an NF-kappaB - and AP-1-dependent mechanism .
11254583	0	interleukin-8	147,160	NF-kappaB	79,88	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	transcription|nmod|START_ENTITY induces|dobj|transcription activate|ccomp|induces activate|dobj|TLR2 TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
11254628	0	interleukin-8	82,95	NF-kappaB	60,69	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	production|amod|START_ENTITY END_ENTITY|dobj|production	Subcytocidal attack by staphylococcal alpha-toxin activates NF-kappaB and induces interleukin-8 production .
12034025	0	interleukin-8	111,124	NF-kappaB	39,48	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	production|amod|START_ENTITY modulates|dobj|production modulates|nsubj|Regulation Regulation|nmod|activation activation|amod|END_ENTITY	Regulation of constitutive and induced NF-kappaB activation in malignant_melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation .
15005855	0	interleukin-8	58,71	NF-kappaB	110,119	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|activation activation|nmod|END_ENTITY	Calcium signaling pathway involving calcineurin regulates interleukin-8 gene expression through activation of NF-kappaB in human osteoblast-like cells .
17366569	0	interleukin-8	130,143	NF-kappaB	77,86	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	expression|amod|START_ENTITY crucial|nmod|expression crucial|nsubj|Activation Activation|nmod|IL-6 IL-6|appos|END_ENTITY	Activation of transcription factor IL-6 -LRB- NF-IL-6 -RRB- and nuclear factor-kappaB -LRB- NF-kappaB -RRB- by lipid ozonation products is crucial to interleukin-8 gene expression in human airway epithelial cells .
18485432	0	interleukin-8	23,36	NF-kappaB	113,122	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	production|amod|START_ENTITY production|nmod|epithelial epithelial|nmod|pathway pathway|amod|END_ENTITY	Hypo-responsiveness of interleukin-8 production in human embryonic epithelial intestine_407 cells independent of NF-kappaB pathway : new lessons from endotoxin and ribotoxic deoxynivalenol .
19448676	0	interleukin-8	50,63	NF-kappaB	90,99	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	CHFR , a potential tumor suppressor , downregulates interleukin-8 through the inhibition of NF-kappaB .
8900181	0	interleukin-8	26,39	NF-kappaB	152,161	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	transcription|amod|START_ENTITY activation|nmod|transcription involves|nsubj|activation involves|dobj|END_ENTITY	Synergistic activation of interleukin-8 gene transcription by all-trans-retinoic_acid and tumor_necrosis_factor-alpha involves the transcription factor NF-kappaB .
9357857	0	interleukin-8	26,39	NF-kappaB	70,79	interleukin-8	NF-kappaB	3576	4790	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|dep|role role|nmod|END_ENTITY	Rhinovirus stimulation of interleukin-8 in vivo and in vitro : role of NF-kappaB .
12909591	0	interleukin-8	71,84	NF-kappa_B	23,33	interleukin-8	NF-kappa B	3576	4790	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles for NF-kappa_B in endotoxin and oxygen induction of interleukin-8 in the macrophage .
8035808	0	interleukin-8	34,47	NF-kappa_B	86,96	interleukin-8	NF-kappa B	3576	4790	Gene	Gene	gene|amod|START_ENTITY inhibition|nmod|gene mediated|nsubjpass|inhibition mediated|nmod|site site|amod|END_ENTITY	Transcriptional inhibition of the interleukin-8 gene by interferon is mediated by the NF-kappa_B site .
8413215	0	interleukin-8	46,59	NF-kappa_B	0,10	interleukin-8	NF-kappa B	3576	4790	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|amod|END_ENTITY	NF-kappa_B subunit-specific regulation of the interleukin-8 promoter .
11254583	0	interleukin-8	147,160	NIK	67,70	interleukin-8	NIK	3576	9020	Gene	Gene	transcription|nmod|START_ENTITY induces|dobj|transcription activate|ccomp|induces activate|dobj|TLR2 TLR2|dep|END_ENTITY	Micrococci and peptidoglycan activate TLR2 -- > MyD88 -- > IRAK -- > TRAF -- > NIK -- > IKK -- > NF-kappaB signal transduction pathway that induces transcription of interleukin-8 .
15755906	0	interleukin-8	23,36	Neurotensin	0,11	interleukin-8	Neurotensin	3576	4922	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Neurotensin stimulates interleukin-8 expression through modulation of I_kappa_B_alpha phosphorylation and p65 transcriptional activity : involvement of protein_kinase_C_alpha .
19720220	0	interleukin-8	22,35	Nrf2	67,71	interleukin-8	Nrf2	3576	4780	Gene	Gene	system|amod|START_ENTITY system|nmod|pathways pathways|amod|END_ENTITY	Heat stress activates interleukin-8 and the antioxidant system via Nrf2 pathways in human_dental_pulp cells .
16365062	0	interleukin-8	88,101	PC-3	127,131	interleukin-8	PC-3	3576	57332	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Soy isoflavones alter expression of genes associated with cancer progression , including interleukin-8 , in androgen-independent PC-3 human prostate_cancer cells .
15641067	0	interleukin-8	8,21	PiT-1	25,30	interleukin-8	PiT-1	3576	6574	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes .
26622904	0	interleukin-8	60,73	Pigment_epithelium-derived_factor	0,33	interleukin-8	Pigment epithelium-derived factor	3576	57104	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Pigment_epithelium-derived_factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate_cancer cells .
17466962	0	interleukin-8	52,65	SMA	102,105	interleukin-8	SMA	20309(Tax:10090)	20589(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA , a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice .
21640118	0	interleukin-8	16,29	SNAIL	0,5	interleukin-8	SNAIL	3576	6615	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SNAIL regulates interleukin-8 expression , stem cell-like activity , and tumorigenicity of human colorectal_carcinoma cells .
16103072	0	interleukin-8	40,53	SRC	27,30	interleukin-8	SRC	3576	6714	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Expression and activity of SRC regulate interleukin-8 expression in pancreatic_adenocarcinoma cells : implications for angiogenesis .
21524887	0	interleukin-8	39,52	Semaphorin_7A	0,13	interleukin-8	Semaphorin 7A	3576	8482	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Semaphorin_7A on keratinocytes induces interleukin-8 production by monocytes .
19758315	0	interleukin-8	63,76	Signal_transducer_and_activator_of_transcription_3	0,50	interleukin-8	Signal transducer and activator of transcription 3	3576	6774	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells .
14561975	0	interleukin-8	20,33	Substance_P	0,11	interleukin-8	Substance P	3576	6863	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Substance_P induces interleukin-8 secretion from human dental pulp cells .
10551153	0	interleukin-8	9,22	THP-1	37,42	interleukin-8	THP-1	3576	2736	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Enhanced interleukin-8 production in THP-1 human monocytic cells by lipopolysaccharide from oral microorganisms and granulocyte-macrophage_colony-stimulating_factor .
11591715	0	interleukin-8	15,28	THP-1	49,54	interleukin-8	THP-1	3576	2736	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Stimulation of interleukin-8 production in human THP-1 macrophages by apolipoprotein -LRB- a -RRB- .
11755918	0	interleukin-8	16,29	THP-1	130,135	interleukin-8	THP-1	3576	2736	Gene	Gene	expression|amod|START_ENTITY Upregulation|nmod|expression metabolite|nsubj|Upregulation metabolite|dobj|14_prostaglandin_J2 14_prostaglandin_J2|nmod|macrophages macrophages|compound|END_ENTITY	Upregulation of interleukin-8 expression by prostaglandin_D2 metabolite 15-deoxy-delta12 , _ 14_prostaglandin_J2 -LRB- 15d-PGJ2 -RRB- in human THP-1 macrophages .
11914967	0	interleukin-8	49,62	THP-1	107,112	interleukin-8	THP-1	3576	2736	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Effect of Mahonia aquifolium active compounds on interleukin-8 production in the human monocytic cell line THP-1 .
9188651	0	interleukin-8	166,179	THP-1	87,92	interleukin-8	THP-1	3576	2736	Gene	Gene	gene|amod|START_ENTITY sites|nmod|gene acting|nmod|sites induces|advcl|acting induces|nmod|line line|appos|END_ENTITY	Human_cytomegalovirus induces interleukin-8 production by a human monocytic cell line , THP-1 , through acting concurrently on AP-1 - and NF-kappaB-binding sites of the interleukin-8 gene .
9188651	0	interleukin-8	30,43	THP-1	87,92	interleukin-8	THP-1	3576	2736	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nmod|line line|appos|END_ENTITY	Human_cytomegalovirus induces interleukin-8 production by a human monocytic cell line , THP-1 , through acting concurrently on AP-1 - and NF-kappaB-binding sites of the interleukin-8 gene .
15652492	0	interleukin-8	18,31	TNF-alpha	0,9	interleukin-8	TNF-alpha	3576	7124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TNF-alpha induces interleukin-8 and endothelin-1 expression in human endothelial cells with different redox pathways .
26386353	0	interleukin-8	62,75	TRPM2	30,35	interleukin-8	TRPM2	3576	7226	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 -LRB- CXCL8 -RRB- production by intracellular Fe -LRB- 2 + -RRB- in human monocytic U937 cells .
8707354	0	interleukin-8	34,47	Thrombin	0,8	interleukin-8	Thrombin	3576	2147	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells stimulates|dobj|production stimulates|nsubj|END_ENTITY	Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells .
10690897	0	interleukin-8	94,107	Tumor_necrosis_factor-alpha	0,27	interleukin-8	Tumor necrosis factor-alpha	3576	7124	Gene	Gene	gene|amod|START_ENTITY inducing|dobj|gene promotes|advcl|inducing promotes|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha promotes proliferation of endometriotic stromal cells by inducing interleukin-8 gene and protein expression .
17003486	0	interleukin-8	59,72	Tumor_necrosis_factor-alpha	0,27	interleukin-8	Tumor necrosis factor-alpha	3576	7124	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells : implications for the genesis of chorioamnionitis .
11784713	0	interleukin-8	104,117	Vascular_endothelial_growth_factor	0,34	interleukin-8	Vascular endothelial growth factor	3576	7422	Gene	Gene	cells|amod|START_ENTITY up-regulation|nmod|cells migration|nmod|up-regulation modulates|dobj|migration modulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells .
15302609	0	interleukin-8	61,74	arylsulfatase-A	119,134	interleukin-8	arylsulfatase-A	3576	410	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Determination of diagnostic and prognostic values of urinary interleukin-8 , tumor_necrosis_factor-alpha , and leukocyte arylsulfatase-A activity in patients with bladder_cancer .
10825374	0	interleukin-8	42,55	beta-endorphin	0,14	interleukin-8	beta-endorphin	3576	5443	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	beta-endorphin inhibits the production of interleukin-8 by human chorio-decidual cells in culture .
16324699	0	interleukin-8	27,40	death_receptor_3	63,79	interleukin-8	death receptor 3	3576	8718	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene transcription|nsubj|regulation transcription|nmod|END_ENTITY	Differential regulation of interleukin-8 gene transcription by death_receptor_3 -LRB- DR3 -RRB- and type I TNF receptor -LRB- TNFRI -RRB- .
12151316	0	interleukin-8	32,45	extracellular_signal-related_kinase	114,149	interleukin-8	extracellular signal-related kinase	3576	5594	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Proteasome inhibitors stimulate interleukin-8 expression via Ras and apoptosis signal-regulating kinase-dependent extracellular_signal-related_kinase and c-Jun_N-terminal_kinase activation .
15550696	0	interleukin-8	33,46	factor_Xa	12,21	interleukin-8	factor Xa	3576	2159	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Coagulation factor_Xa stimulates interleukin-8 release in endothelial cells and mononuclear leukocytes : implications in acute_myocardial_infarction .
10712390	0	interleukin-8	85,98	granulocyte-macrophage_colony-stimulating_factor	27,75	interleukin-8	granulocyte-macrophage colony-stimulating factor	3576	1437	Gene	Gene	production|dep|START_ENTITY production|amod|END_ENTITY	Cyclooxygenase-2 regulates granulocyte-macrophage_colony-stimulating_factor , but not interleukin-8 , production by human vascular cells : role of cAMP .
7678512	0	interleukin-8	80,93	granulocyte-macrophage_colony-stimulating_factor	10,58	interleukin-8	granulocyte-macrophage colony-stimulating factor	3576	1437	Gene	Gene	production|amod|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of granulocyte-macrophage_colony-stimulating_factor and interleukin-3 on interleukin-8 production by human neutrophils and monocytes .
16734147	0	interleukin-8	91,104	granulocyte-macrophage_colony_stimulating_factor	41,89	interleukin-8	granulocyte-macrophage colony stimulating factor	3576	1437	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Production of proinflammatory cytokines : granulocyte-macrophage_colony_stimulating_factor , interleukin-8 and interleukin-6 by peripheral blood mononuclear cells of protein energy malnourished children .
19028451	0	interleukin-8	44,57	heat_shock_protein_90	14,35	interleukin-8	heat shock protein 90	3576	3320	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Extracellular heat_shock_protein_90 induces interleukin-8 in vascular smooth muscle cells .
12600410	0	interleukin-8	14,27	interferon-gamma	69,85	interleukin-8	interferon-gamma	3576	3458	Gene	Gene	levels|amod|START_ENTITY Modulation|nmod|levels Modulation|nmod|END_ENTITY	Modulation of interleukin-8 and nitric_oxide_synthase mRNA levels by interferon-gamma in macrophages stimulated with lignin derivatives and lipopolysaccharides .
17536259	0	interleukin-8	196,209	interferon-gamma	44,60	interleukin-8	interferon-gamma	3576	3458	Gene	Gene	-RSB-|amod|START_ENTITY cell|nmod|-RSB- mononuclear|dobj|cell mononuclear|nsubj|Effects Effects|nmod|triptolide triptolide|nmod|production production|nmod|END_ENTITY	-LSB- Effects of triptolide on the production of interferon-gamma in human peripheral blood mononuclear cell and phosphorylation of signal_transducer_and_activator_of_transcription-1 and production of interleukin-8 -RSB- .
7575406	0	interleukin-8	27,40	interferon-gamma	110,126	interleukin-8	interferon-gamma	3576	3458	Gene	Gene	expression|amod|START_ENTITY expression|dep|inhibition inhibition|nmod|END_ENTITY	Lipopolysaccharide-induced interleukin-8 gene expression in human granulocytes : transcriptional inhibition by interferon-gamma .
7655023	0	interleukin-8	35,48	interferon-gamma	143,159	interleukin-8	interferon-gamma	3576	3458	Gene	Gene	induces|dobj|START_ENTITY induces|parataxis|regulation regulation|nmod|END_ENTITY	Leukemia_inhibitory_factor induces interleukin-8 and monocyte_chemotactic_and_activating_factor in human monocytes : differential regulation by interferon-gamma .
2039486	0	interleukin-8	60,73	interleukin-1	38,51	interleukin-8	interleukin-1	3576	3552	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	1,25 -LRB- OH -RRB- 2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production .
12093676	0	interleukin-8	14,27	interleukin-10	31,45	interleukin-8	interleukin-10	3576	3586	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of interleukin-8 by interleukin-10 and transforming_growth_factor_beta in human monocytes infected with mycobacterium_bovis .
9757992	0	interleukin-8	63,76	interleukin-10	45,59	interleukin-8	interleukin-10	3576	3586	Gene	Gene	release|amod|START_ENTITY END_ENTITY|nmod|release	The effect of transforming growth factor and interleukin-10 on interleukin-8 release by human amniochorion may regulate histologic chorioamnionitis .
15005008	0	interleukin-8	117,130	interleukin-11	64,78	interleukin-8	interleukin-11	3576	3589	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effects of physiological concentrations of steroid hormones and interleukin-11 on basal and stimulated production of interleukin-8 by human osteoblast-like cells with different functional profiles .
8216423	0	interleukin-8	76,89	interleukin-1_beta	22,40	interleukin-8	interleukin-1 beta	3576	3553	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Synergistic effect of interleukin-1_beta and tumor_necrosis_factor_alpha on interleukin-8 gene expression in synovial fibroblasts .
21786164	0	interleukin-8	113,126	interleukin-1a	81,95	interleukin-8	interleukin-1a	3576	3552	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Duration of wound fluid secretion from chronic venous_leg_ulcers is critical for interleukin-1a , interleukin-1b , interleukin-8 levels and fibroblast activation .
22675954	0	interleukin-8	73,86	interleukin-1alpha	14,32	interleukin-8	interleukin-1alpha	3576	3552	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Regulation of interleukin-1alpha and tumor_necrosis_factor-alpha-induced interleukin-8 production by amnion-derived -LRB- WISH -RRB- cells .
21786164	0	interleukin-8	113,126	interleukin-1b	97,111	interleukin-8	interleukin-1b	3576	3553	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Duration of wound fluid secretion from chronic venous_leg_ulcers is critical for interleukin-1a , interleukin-1b , interleukin-8 levels and fibroblast activation .
10641976	0	interleukin-8	13,26	interleukin-1beta	139,156	interleukin-8	interleukin-1beta	3576	3553	Gene	Gene	release|amod|START_ENTITY Induction|nmod|release affected|nsubjpass|Induction affected|nmod|inhibitors inhibitors|nmod|END_ENTITY	Induction of interleukin-8 release by lung epithelium with cystic_fibrosis epithelial lining fluid is marginally affected by inhibitors of interleukin-1beta .
12533683	0	interleukin-8	156,169	interleukin-1beta	79,96	interleukin-8	interleukin-1beta	3576	3553	Gene	Gene	CXCL8|amod|START_ENTITY comparison|nmod|CXCL8 GCP-2|dep|comparison GCP-2|dep|induced induced|advcl|END_ENTITY	The CXC chemokine GCP-2 / CXCL6 is predominantly induced in mesenchymal cells by interleukin-1beta and is down-regulated by interferon-gamma : comparison with interleukin-8 / CXCL8 .
16678783	0	interleukin-8	49,62	interleukin-1beta	120,137	interleukin-8	interleukin-1beta	3576	3553	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nmod|fibroblasts fibroblasts|acl|stimulated stimulated|advcl|END_ENTITY	Epidermal_growth_factor synergistically enhances interleukin-8 production in human gingival fibroblasts stimulated with interleukin-1beta .
8663179	0	interleukin-8	14,27	interleukin-1beta	47,64	interleukin-8	interleukin-1beta	3576	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|hormones hormones|amod|END_ENTITY	Regulation of interleukin-8 gene expression by interleukin-1beta , osteotropic hormones , and protein kinase inhibitors in normal human bone marrow stromal cells .
9797111	0	interleukin-8	62,75	interleukin-1beta	43,60	interleukin-8	interleukin-1beta	100009129(Tax:9986)	100008990(Tax:9986)	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	Analysis of the cytokine interaction among interleukin-1beta , interleukin-8 , and interleukin-1 receptor antagonist in the rabbit ovulatory process .
11858100	0	interleukin-8	54,67	interleukin-2	39,52	interleukin-8	interleukin-2	3576	3558	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	-LSB- Levels of anti-inflammatory cytokines interleukin-2 , interleukin-8 , and soluble interleukin-2 receptor in blood of patients with various forms of ischemic_heart_disease -RSB- .
11858100	0	interleukin-8	54,67	interleukin-2	81,94	interleukin-8	interleukin-2	3576	3558	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	-LSB- Levels of anti-inflammatory cytokines interleukin-2 , interleukin-8 , and soluble interleukin-2 receptor in blood of patients with various forms of ischemic_heart_disease -RSB- .
15452601	0	interleukin-8	40,53	interleukin-2	69,82	interleukin-8	interleukin-2	3576	3558	Gene	Gene	correction|amod|START_ENTITY correction|nmod|production production|compound|END_ENTITY	Fibrinogen and its oxidized form induce interleukin-8 -LSB- correction of interleukin-2 -RSB- production in cultured endothelial cells of human vessels .
7696165	0	interleukin-8	15,28	interleukin-2	69,82	interleukin-8	interleukin-2	3576	3558	Gene	Gene	treatment|amod|START_ENTITY release|nmod|treatment release|nmod|END_ENTITY	The release of interleukin-8 during intravenous bolus treatment with interleukin-2 .
10476751	0	interleukin-8	61,74	interleukin-6	46,59	interleukin-8	interleukin-6	3576	3569	Gene	Gene	type|amod|START_ENTITY type|amod|END_ENTITY	Assessment of measuring circulating levels of interleukin-6 , interleukin-8 , C-reactive_protein , soluble Fc gamma receptor type III , and mannose-binding_protein in febrile children with cancer and neutropenia .
7737976	0	interleukin-8	31,44	interleukin-8_receptor_type_A	87,116	interleukin-8	interleukin-8 receptor type A	3576	3577	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	The role of Tyr13 and Lys15 of interleukin-8 in the high affinity interaction with the interleukin-8_receptor_type_A .
1755377	0	interleukin-8	129,142	interleukin_8	20,33	interleukin-8	interleukin 8	3576	3576	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of human interleukin_8 gene expression and binding of several other members of the intercrine family to receptors for interleukin-8 .
9633928	0	interleukin-8	41,54	monocyte_chemoattractant_protein-1	102,136	interleukin-8	monocyte chemoattractant protein-1	3576	6347	Gene	Gene	production|nmod|START_ENTITY production|dep|END_ENTITY	Cyclic stretch upregulates production of interleukin-8 and monocyte_chemotactic_and_activating_factor / monocyte_chemoattractant_protein-1 in human endothelial cells .
17720627	0	interleukin-8	64,77	nasopharyngeal_carcinoma	88,112	interleukin-8	nasopharyngeal carcinoma	3576	4864	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal_carcinoma .
1899427	0	interleukin-8	55,68	neutrophil-activating_peptide-1	23,54	interleukin-8	neutrophil-activating peptide-1	3576	3576	Gene	Gene	production|dep|START_ENTITY production|nmod|END_ENTITY	Enhanced production of neutrophil-activating_peptide-1 / interleukin-8 in rheumatoid_arthritis .
20185670	0	interleukin-8	87,100	nuclear_factor-kappaB	64,85	interleukin-8	nuclear factor-kappaB	3576	4790	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Ketamine inhibits transcription factors activator_protein_1 and nuclear_factor-kappaB , interleukin-8 production , as well as CD11b and CD16 expression : studies in human leukocytes and leukocytic cell lines .
20185670	0	interleukin-8	87,100	nuclear_factor-kappaB	64,85	interleukin-8	nuclear factor-kappaB	3576	4790	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Ketamine inhibits transcription factors activator_protein_1 and nuclear_factor-kappaB , interleukin-8 production , as well as CD11b and CD16 expression : studies in human leukocytes and leukocytic cell lines .
12897563	0	interleukin-8	38,51	nuclear_factor-kappa_B	12,34	interleukin-8	nuclear factor-kappa B	3576	4790	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of nuclear_factor-kappa_B in interleukin-8 expression by human adenoidal fibroblasts .
7812007	0	interleukin-8	111,124	phospholipase_D	165,180	interleukin-8	phospholipase D	3576	2822	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|amod|END_ENTITY	Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils : interleukin-8 , but not NAP-2 or GRO_alpha , stimulates phospholipase_D activity .
9227331	0	interleukin-8	34,47	platelet-activating_factor	56,82	interleukin-8	platelet-activating factor	3576	9768	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the interleukin-8 gene by platelet-activating_factor in human peripheral blood monocytes .
10643587	0	interleukin-8	21,34	platelet-activating_factor_acetylhydrolase	55,97	interleukin-8	platelet-activating factor acetylhydrolase	3576	7941	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	Inhibitory effect of interleukin-8 on the secretion of platelet-activating_factor_acetylhydrolase by human decidual macrophages .
18212111	0	interleukin-8	55,68	protease-activated_receptor_2	81,110	interleukin-8	protease-activated receptor 2	3576	2150	Gene	Gene	production|nmod|START_ENTITY macrolides|nmod|production Effect|nmod|macrolides mediated|nsubj|Effect mediated|advcl|END_ENTITY	Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated_receptor_2 in human keratinocytes .
12857601	0	interleukin-8	31,44	serum_amyloid_A	56,71	interleukin-8	serum amyloid A	3576	6287	Gene	Gene	expression|nmod|START_ENTITY induced|nsubj|expression induced|nmod|END_ENTITY	mRNA expression and release of interleukin-8 induced by serum_amyloid_A in neutrophils and monocytes .
15975819	0	interleukin-8	23,36	transforming_growth_factor-beta_1	80,113	interleukin-8	transforming growth factor-beta 1	3576	7040	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|nmod|END_ENTITY	Selective induction of interleukin-8 expression in metastatic melanoma cells by transforming_growth_factor-beta_1 .
8768866	0	interleukin-8	73,86	transforming_growth_factor-beta_1	143,176	interleukin-8	transforming growth factor-beta 1	3576	7040	Gene	Gene	synthesis|amod|START_ENTITY synthesis|advcl|END_ENTITY	Modulation of the levels of interleukin-8 messenger ribonucleic_acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming_growth_factor-beta_1 .
22293942	0	interleukin-8	103,116	transforming_growth_factor_beta	125,156	interleukin-8	transforming growth factor beta	3576	7040	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Association of glutathione_S-transferase 1-1 polymorphisms -LRB- A140D and E208K -RRB- with the expression of interleukin-8 -LRB- IL-8 -RRB- , transforming_growth_factor_beta -LRB- TGF-b -RRB- , and apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- in humans chronically exposed to arsenic in drinking water .
11460304	0	interleukin-8	104,117	tumor_necrosis_factor-alpha	11,38	interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	production|amod|START_ENTITY factor|nmod|production factor|amod|END_ENTITY	Effects of tumor_necrosis_factor-alpha , epidermal growth factor and transforming growth factor-alpha on interleukin-8 production by , and human rhinovirus replication in , bronchial epithelial cells .
15302609	0	interleukin-8	61,74	tumor_necrosis_factor-alpha	76,103	interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Determination of diagnostic and prognostic values of urinary interleukin-8 , tumor_necrosis_factor-alpha , and leukocyte arylsulfatase-A activity in patients with bladder_cancer .
15845864	0	interleukin-8	39,52	tumor_necrosis_factor-alpha	85,112	interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	production|amod|START_ENTITY hyperresponsive|dobj|production hyperresponsive|nmod|END_ENTITY	Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor_necrosis_factor-alpha in structural lung cells .
1702929	0	interleukin-8	25,38	tumor_necrosis_factor-alpha	56,83	interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cellular localization of interleukin-8 and its inducer , tumor_necrosis_factor-alpha in psoriasis .
17671691	0	interleukin-8	13,26	tumor_necrosis_factor-alpha	39,66	interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	CXCL-8|amod|START_ENTITY CXCL-8|nmod|END_ENTITY	Induction of interleukin-8 -LRB- CXCL-8 -RRB- by tumor_necrosis_factor-alpha and leukemia_inhibitory_factor in pancreatic_carcinoma cells : Impact of CXCL-8 as an autocrine growth factor .
8832978	0	interleukin-8	73,86	tumor_necrosis_factor-alpha	21,48	interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	monocyte_chemoattractant_protein-1|amod|START_ENTITY stimulation|nmod|monocyte_chemoattractant_protein-1 stimulation|amod|END_ENTITY	Antioxidants inhibit tumor_necrosis_factor-alpha mediated stimulation of interleukin-8 , monocyte_chemoattractant_protein-1 , and collagenase expression in cultured human synovial cells .
9081478	0	interleukin-8	55,68	tumor_necrosis_factor-alpha	11,38	interleukin-8	tumor necrosis factor-alpha	3576	7124	Gene	Gene	-RSB-|amod|START_ENTITY Effect|nmod|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect of tumor_necrosis_factor-alpha on synthesis of interleukin-8 by human monocytes and lymphocytes in vitro -RSB- .
10477716	0	interleukin-8	45,58	tumor_necrosis_factor_alpha	78,105	interleukin-8	tumor necrosis factor alpha	3576	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor_necrosis_factor_alpha : evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation .
12767906	0	interleukin-8	93,106	tumor_necrosis_factor_alpha	134,161	interleukin-8	tumor necrosis factor alpha	3576	7124	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	Insulin-like growth factor-1 downregulates nuclear factor kappa B activation and upregulates interleukin-8 gene expression induced by tumor_necrosis_factor_alpha .
17332916	0	interleukin-8	44,57	urokinase-type_plasminogen_activator	58,94	interleukin-8	urokinase-type plasminogen activator	3576	5328	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Cyclooxygenase-2 uses the protein_kinase_C / interleukin-8 / urokinase-type_plasminogen_activator pathway to increase the invasiveness of breast_cancer cells .
20156197	0	interleukin-8	75,88	vascular_endothelial_growth_factor	16,50	interleukin-8	vascular endothelial growth factor	280828(Tax:9913)	281572(Tax:9913)	Gene	Gene	IL-8|dep|START_ENTITY expression|nmod|IL-8 Effect|nmod|expression Effect|appos|END_ENTITY	Effect of VEGF -LRB- vascular_endothelial_growth_factor -RRB- on expression of IL-8 -LRB- interleukin-8 -RRB- , IL-1beta and their receptors in bovine theca cells .
20334899	0	interleukin-8	130,143	vascular_endothelial_growth_factor	94,128	interleukin-8	vascular endothelial growth factor	3576	7422	Gene	Gene	impulses|dep|START_ENTITY impulses|nmod|END_ENTITY	Expression of angiostatic platelet factor-4var / CXCL4L1 counterbalances angiogenic impulses of vascular_endothelial_growth_factor , interleukin-8 / CXCL8 , and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal_cancer .
20709566	0	interleukin-8_and_tumor_necrosis_factor_alpha	86,131	interleukin-6	71,84	interleukin-8 and tumor necrosis factor alpha	interleukin-6	3576;7124	3569	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Paget 's _ disease_of_bone is not associated with common polymorphisms in interleukin-6 , interleukin-8_and_tumor_necrosis_factor_alpha genes .
18657446	0	interleukin-8_receptor	50,72	IL-8R	74,79	interleukin-8 receptor	IL-8R	100135914(Tax:8022)	100135914(Tax:8022)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- interleukin-8_receptor -LRB- IL-8R -RRB- gene transcription in response to viral_hemorrhagic_septicemia virus -LRB- VHSV -RRB- , DNA vaccination and chemokines .
7737976	0	interleukin-8_receptor_type_A	87,116	interleukin-8	31,44	interleukin-8 receptor type A	interleukin-8	3577	3576	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	The role of Tyr13 and Lys15 of interleukin-8 in the high affinity interaction with the interleukin-8_receptor_type_A .
1680606	0	interleukin-9	57,70	IL9	72,75	interleukin-9	IL9	3578	3578	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Regional localization of the human glutaminase -LRB- GLS -RRB- and interleukin-9 -LRB- IL9 -RRB- genes by in situ hybridization .
9671468	0	interleukin-9	98,111	adseverin	7,16	interleukin-9	adseverin	16198(Tax:10090)	20259(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Murine adseverin -LRB- D5 -RRB- , a novel member of the gelsolin family , and murine adseverin are induced by interleukin-9 in T-helper lymphocytes .
1382699	0	interleukin-9	18,31	steel_factor	93,105	interleukin-9	steel factor	3578	4254	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel_factor to stimulate proliferation of the human factor-dependent cell line , M07e .
6602846	0	interleukin_1	15,28	B_cell_activation	38,55	interleukin 1	B cell activation	3552	29760	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of interleukin_1 on human B_cell_activation and proliferation .
2535139	0	interleukin_1	25,38	Beta-endorphin	0,14	interleukin 1	Beta-endorphin	111343(Tax:10090)	18976(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Beta-endorphin regulates interleukin_1 production and release by murine bone marrow macrophages .
1690130	0	interleukin_1	25,38	C5a	12,15	interleukin 1	C5a	3552	728	Gene	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Recombinant C5a enhances interleukin_1 and tumor_necrosis_factor release by lipopolysaccharide-stimulated monocytes and macrophages .
3116090	0	interleukin_1	23,36	C5a	0,3	interleukin 1	C5a	3552	728	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	C5a induction of human interleukin_1 .
6809882	0	interleukin_1	13,26	C5a	119,122	interleukin 1	C5a	3552	728	Gene	Gene	secretion|amod|START_ENTITY Induction|nmod|secretion Induction|nmod|receptors receptors|amod|binding binding|nmod|END_ENTITY	Induction of interleukin_1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors .
6809882	0	interleukin_1	13,26	C5a	93,96	interleukin 1	C5a	3552	728	Gene	Gene	secretion|amod|START_ENTITY Induction|nmod|secretion Induction|nmod|receptors receptors|amod|binding binding|nmod|END_ENTITY	Induction of interleukin_1 secretion and enhancement of humoral immunity by binding of human C5a to macrophage surface C5a receptors .
3493098	0	interleukin_1	27,40	IL-1	42,46	interleukin 1	IL-1	3552	3552	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Increased production of an interleukin_1 -LRB- IL-1 -RRB- inhibitor with fibroblast stimulating activity by mononuclear cells from patients with scleroderma .
8131658	0	interleukin_1	81,94	IL-1	96,100	interleukin 1	IL-1	3552	3552	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- The influence of Chinese traditional medicine on the production and activity of interleukin_1 -LRB- IL-1 -RRB- -RSB- .
1904523	0	interleukin_1	41,54	Interferon_gamma	0,16	interleukin 1	Interferon gamma	111343(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Interferon_gamma modulates production of interleukin_1 and tumor_necrosis_factor by murine Kupffer cells .
7487347	1	interleukin_1	90,103	Interleukin_6	35,48	interleukin 1	Interleukin 6	3552	3569	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin_6 produced by activated thymocytes induces interleukin_1 production by macrophages .
8438219	0	interleukin_1	51,64	TNF_alpha	39,48	interleukin 1	TNF alpha	3552	7124	Gene	Gene	tumor_necrosis_factor_alpha|appos|START_ENTITY tumor_necrosis_factor_alpha|appos|END_ENTITY	Increased tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- , interleukin_1 , and interleukin_6 -LRB- IL-6 -RRB- levels in the plasma of stored platelet concentrates : relationship between TNF_alpha and IL-6 levels and febrile transfusion reactions .
3013994	0	interleukin_1	10,23	Tac_antigen	69,80	interleukin 1	Tac antigen	3552	3559	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of interleukin_1 on the expression of interleukin 2 receptor -LRB- Tac_antigen -RRB- on human natural killer cells and natural killer-like cell line -LRB- YT cells -RRB- .
2550484	0	interleukin_1	89,102	Tumor_necrosis_factor	0,21	interleukin 1	Tumor necrosis factor	3552	7124	Gene	Gene	causes|nmod|START_ENTITY causes|nsubj|END_ENTITY	Tumor_necrosis_factor causes amplification of arachidonic_acid metabolism in response to interleukin_1 , bradykinin , and other agonists .
3538018	0	interleukin_1	90,103	Uromodulin	0,10	interleukin 1	Uromodulin	3552	7369	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Uromodulin , an immunosuppressive protein derived from pregnancy urine , is an inhibitor of interleukin_1 .
2104217	0	interleukin_1	30,43	granulocyte-macrophage_colony-stimulating_factor	89,137	interleukin 1	granulocyte-macrophage colony-stimulating factor	3552	1437	Gene	Gene	inhibitor|amod|START_ENTITY Production|nmod|inhibitor regulated|nsubjpass|Production regulated|nmod|END_ENTITY	Production of a 26,000-dalton interleukin_1 inhibitor by human monocytes is regulated by granulocyte-macrophage_colony-stimulating_factor .
2116051	0	interleukin_1	102,115	interferon-gamma	20,36	interleukin 1	interferon-gamma	3552	3458	Gene	Gene	produce|dobj|START_ENTITY activates|xcomp|produce activates|nsubj|END_ENTITY	Recombinant porcine interferon-gamma activates in vitro porcine adherent mononuclear cells to produce interleukin_1 .
2424621	0	interleukin_1	22,35	interferon-gamma	70,86	interleukin 1	interferon-gamma	3552	3458	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The direct effects of interleukin_1 , interleukin_2 , interferon-alpha , interferon-gamma , B-cell growth factor , and a B-cell_differentiation_factor on resting and activated human B cells .
3086435	0	interleukin_1	75,88	interferon-gamma	37,53	interleukin 1	interferon-gamma	3552	3458	Gene	Gene	roles|nmod|START_ENTITY production|dep|roles production|amod|END_ENTITY	Bacterial lipopolysaccharide-induced interferon-gamma production : roles of interleukin_1 and interleukin_2 .
3104062	0	interleukin_1	62,75	interferon-gamma	13,29	interleukin 1	interferon-gamma	3552	3458	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Induction of interferon-gamma production and Ia expression by interleukin_1 in bone marrow culture cells .
2125034	0	interleukin_1	18,31	interferon_gamma	46,62	interleukin 1	interferon gamma	3552	3458	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	The modulation of interleukin_1 production by interferon_gamma , and the inhibitory effects of gold compounds .
8580384	0	interleukin_1	43,56	interleukin_10	25,39	interleukin 1	interleukin 10	3552	3586	Gene	Gene	circulating|nmod|START_ENTITY circulating|dobj|END_ENTITY	Induction of circulating interleukin_10 by interleukin_1 and interleukin_2 , but not interleukin_6 immunotherapy .
2104213	0	interleukin_1	185,198	interleukin_2	168,181	interleukin 1	interleukin 2	3552	3558	Gene	Gene	-LSB-|amod|START_ENTITY END_ENTITY|nmod|-LSB-	Accessory cell-derived helper signals in human T-cell activation with phytohemagglutinin : induction of interleukin_2-responsiveness by interleukin_6 , and production of interleukin_2 by interleukin_1 -LSB- corrected -RSB- .
2424621	0	interleukin_1	22,35	interleukin_2	37,50	interleukin 1	interleukin 2	3552	3558	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The direct effects of interleukin_1 , interleukin_2 , interferon-alpha , interferon-gamma , B-cell growth factor , and a B-cell_differentiation_factor on resting and activated human B cells .
2458871	0	interleukin_1	54,67	interleukin_2	69,82	interleukin 1	interleukin 2	3552	3558	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Multiple_sclerosis : effect of myelin_basic_protein on interleukin_1 , interleukin_2 production and interleukin_2 receptor expression in vitro .
2550707	0	interleukin_1	99,112	interleukin_2	26,39	interleukin 1	interleukin 2	3552	3558	Gene	Gene	pathway|amod|START_ENTITY pathways|dep|pathway pathways|acl|inducing inducing|dobj|production production|amod|END_ENTITY	Two pathways for inducing interleukin_2 production in MOLT_16 cells , a human leukemic_T-cell line : interleukin_1 pathway and interleukin_1-independent pathway .
2783241	0	interleukin_1	29,42	interleukin_2	48,61	interleukin 1	interleukin 2	3552	3558	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|nmod|END_ENTITY	Synergy of human recombinant interleukin_1 with interleukin_2 in the generation of lymphokine-activated killer cells .
3009609	2	interleukin_1	111,124	interleukin_2	157,170	interleukin 1	interleukin 2	3552	3558	Gene	Gene	inhibitor|nmod|START_ENTITY downregulates|nsubj|inhibitor downregulates|dobj|production production|nmod|END_ENTITY	A monocyte-dependent inhibitor of interleukin_1 downregulates the production of interleukin_2 and interferon-gamma in rheumatoid_arthritis .
3090248	0	interleukin_1	9,22	interleukin_2	37,50	interleukin 1	interleukin 2	3552	3558	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Enhanced interleukin_1 and depressed interleukin_2 production in juvenile_arthritis .
3880962	2	interleukin_1	62,75	interleukin_2	90,103	interleukin 1	interleukin 2	3552	3558	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Normal interleukin_1 and defective interleukin_2 production in short-term patients and in those with chronic_graft-versus-host_disease .
3920312	0	interleukin_1	81,94	interleukin_2	13,26	interleukin 1	interleukin 2	111343(Tax:10090)	16183(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY responsiveness|nmod|action responsiveness|nsubj|Induction Induction|nmod|END_ENTITY	Induction of interleukin_2 responsiveness in thymocytes by synergistic action of interleukin_1 and interleukin_2 .
6235287	0	interleukin_1	106,119	interleukin_2	168,181	interleukin 1	interleukin 2	3552	3558	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|expression expression|nmod|receptors receptors|nmod|END_ENTITY	Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor : interleukin_1 is required for the expression of receptors for interleukin_2 .
12879762	0	interleukin_1	28,41	interleukin_6	43,56	interleukin 1	interleukin 6	3552	3569	Gene	Gene	plasma|nummod|START_ENTITY plasma|nummod|END_ENTITY	-LSB- Predictive value of plasma interleukin_1 , interleukin_6 , interleukin_8 and C-reactive_protein -LRB- CRP -RRB- in patients with myocardial_infarction -RSB- .
1959943	0	interleukin_1	100,113	interleukin_6	24,37	interleukin 1	interleukin 6	111343(Tax:10090)	16193(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY stimulation|nmod|induction production|dep|stimulation production|nmod|END_ENTITY	Defective production of interleukin_6 by macrophages from C3H/HeJ mice : differential stimulation of interleukin_1 and interleukin_6 induction .
2407240	0	interleukin_1	63,76	interleukin_6	25,38	interleukin 1	interleukin 6	3552	3569	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Independent induction of interleukin_6 and prostaglandin_E2 by interleukin_1 in human articular chondrocytes .
12879762	0	interleukin_1	28,41	interleukin_8	58,71	interleukin 1	interleukin 8	3552	3576	Gene	Gene	plasma|nummod|START_ENTITY plasma|nummod|END_ENTITY	-LSB- Predictive value of plasma interleukin_1 , interleukin_6 , interleukin_8 and C-reactive_protein -LRB- CRP -RRB- in patients with myocardial_infarction -RSB- .
7511604	0	interleukin_1	60,73	keratinocyte_growth_factor	14,40	interleukin 1	keratinocyte growth factor	3552	2252	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of keratinocyte_growth_factor gene expression by interleukin_1 .
15901641	0	interleukin_1	97,110	macrophage_migration_inhibitory_factor	15,53	interleukin 1	macrophage migration inhibitory factor	3552	4282	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Stimulation of macrophage_migration_inhibitory_factor expression in endometrial stromal cells by interleukin_1 , beta involving the nuclear transcription factor NFkappaB .
2458871	0	interleukin_1	54,67	myelin_basic_protein	30,50	interleukin 1	myelin basic protein	3552	4155	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Multiple_sclerosis : effect of myelin_basic_protein on interleukin_1 , interleukin_2 production and interleukin_2 receptor expression in vitro .
11550712	0	interleukin_1	10,23	phospholipase_D	66,81	interleukin 1	phospholipase D	3552	2822	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|amod|END_ENTITY	Effect of interleukin_1 , lipopolysaccharide and phorbol_esters on phospholipase_D activity in chondrocytes .
3494060	0	interleukin_1	33,46	tumor_necrosis_factor	50,71	interleukin 1	tumor necrosis factor	3552	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of membrane-associated interleukin_1 by tumor_necrosis_factor in human fibroblasts .
1677177	0	interleukin_1-beta	35,53	p24	55,58	interleukin 1-beta	p24	3553	10959	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Serum tumor_necrosis_factor alpha , interleukin_1-beta , p24 antigen concentrations and CD4 + cells at various stages of human_immunodeficiency_virus_1_infection in children .
8202660	0	interleukin_1-beta	16,34	tumor_necrosis_factor-alpha	36,63	interleukin 1-beta	tumor necrosis factor-alpha	3553	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Serum levels of interleukin_1-beta , tumor_necrosis_factor-alpha , soluble interleukin 2 receptor and soluble CD8 in seronegative spondylarthropathies .
1334711	0	interleukin_10	45,59	BCRF1	19,24	interleukin 10	BCRF1	3586	3783690(Tax:10376)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Epstein-Barr_virus BCRF1 gene product -LRB- viral interleukin_10 -RRB- inhibits superoxide anion production by human monocytes .
1421000	0	interleukin_10	12,26	IL-10	28,33	interleukin 10	IL-10	3586	3586	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of interleukin_10 -LRB- IL-10 -RRB- in the ascites of patients with ovarian and other intra-abdominal_cancers .
23069299	0	interleukin_10	51,65	IL-10	67,72	interleukin 10	IL-10	3586	3586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of tumor_necrosis_factor_a -LRB- TNF-a -RRB- and interleukin_10 -LRB- IL-10 -RRB- gene polymorphisms in dermatomyositis patients : a pilot study .
8426121	0	interleukin_10	26,40	Interferon_gamma	0,16	interleukin 10	Interferon gamma	3586	3458	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interferon_gamma inhibits interleukin_10 production by monocytes .
17068066	0	interleukin_10	216,230	Toll-like_receptor_4	0,20	interleukin 10	Toll-like receptor 4	16153(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY potentiates|parataxis|regulates potentiates|nsubj|expression expression|nummod|END_ENTITY	Toll-like_receptor_4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis : Toll-like_receptor_4 largely regulates FcgammaR expression by interleukin_10 .
17068066	0	interleukin_10	216,230	Toll-like_receptor_4	154,174	interleukin 10	Toll-like receptor 4	16153(Tax:10090)	21898(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Toll-like_receptor_4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis : Toll-like_receptor_4 largely regulates FcgammaR expression by interleukin_10 .
11297268	0	interleukin_10	14,28	bcl-2	72,77	interleukin 10	bcl-2	3586	596	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of interleukin_10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin 's _ lymphoma to apoptosis .
8580384	0	interleukin_10	25,39	interleukin_1	43,56	interleukin 10	interleukin 1	3586	3552	Gene	Gene	circulating|dobj|START_ENTITY circulating|nmod|END_ENTITY	Induction of circulating interleukin_10 by interleukin_1 and interleukin_2 , but not interleukin_6 immunotherapy .
10843767	0	interleukin_11	11,25	IL-11	27,32	interleukin 11	IL-11	171040(Tax:10116)	171040(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of interleukin_11 -LRB- IL-11 -RRB- on early post-implantation development of the rat .
16860880	0	interleukin_11	33,47	Interleukin_1_beta	0,18	interleukin 11	Interleukin 1 beta	3589	3553	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Interleukin_1_beta is induced by interleukin_11 during decidualization of human endometrial stromal cells , but is not released in a bioactive form .
21730055	0	interleukin_12_p40	64,82	IL-12p40	84,92	interleukin 12 p40	IL-12p40	16160(Tax:10090)	16160(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Morphine withdrawal stress modulates lipopolysaccharide-induced interleukin_12_p40 -LRB- IL-12p40 -RRB- expression by activating extracellular_signal-regulated_kinase_1 / 2 , which is further potentiated by glucocorticoids .
15993716	0	interleukin_12_receptor	27,50	IL12RB1	52,59	interleukin 12 receptor	IL12RB1	3594	3594	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin 12 -LRB- IL12B -RRB- and interleukin_12_receptor -LRB- IL12RB1 -RRB- gene polymorphisms in rheumatoid_arthritis .
21097505	0	interleukin_13	4,18	IL-13	20,25	interleukin 13	IL-13	3596	3596	Gene	Gene	pathway|compound|START_ENTITY pathway|appos|END_ENTITY	The interleukin_13 -LRB- IL-13 -RRB- pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin_13 receptor alpha1 -LRB- IL13Ralpha1 -RRB- .
10394106	0	interleukin_13	53,67	stem_cell_factor	87,103	interleukin 13	stem cell factor	3596	4254	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Cord-blood-derived human cultured mast cells produce interleukin_13 in the presence of stem_cell_factor .
12816724	0	interleukin_13_alpha_2_receptor	50,81	IL-13Ra2	83,91	interleukin 13 alpha 2 receptor	IL-13Ra2	3598	3598	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Molecular cloning and identification of the human interleukin_13_alpha_2_receptor -LRB- IL-13Ra2 -RRB- promoter .
20068108	0	interleukin_13_receptor_alpha2	52,82	Interleukin_13	0,14	interleukin 13 receptor alpha2	Interleukin 13	3598	3596	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Interleukin_13 mediates signal transduction through interleukin_13_receptor_alpha2 in pancreatic_ductal_adenocarcinoma : role of IL-13 Pseudomonas exotoxin in pancreatic_cancer therapy .
24415300	0	interleukin_15	19,33	IL-15	35,40	interleukin 15	IL-15	3600	3600	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the interleukin_15 -LRB- IL-15 -RRB- gene polymorphisms with the risk of developing ulcerative_colitis in Mexican individuals .
8932977	0	interleukin_15	60,74	IL-15	81,86	interleukin 15	IL-15	3600	3600	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosomal localization of the human interleukin_15 gene -LRB- IL-15 -RRB- .
9180138	0	interleukin_15	14,28	IL-15	30,35	interleukin 15	IL-15	3600	3600	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of interleukin_15 -LRB- IL-15 -RRB- in human rhabdomyosarcoma , osteosarcoma and Ewing 's _ sarcoma .
11709514	0	interleukin_16	43,57	Interleukin_16	0,14	interleukin 16	Interleukin 16	3603	3603	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Interleukin_16 expression and phenotype of interleukin_16 producing cells in Crohn 's _ disease .
19616200	0	interleukin_17	86,100	CD4	11,14	interleukin 17	CD4	3605	920	Gene	Gene	Foxp3|appos|START_ENTITY granzyme_B|appos|Foxp3 expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19616200	0	interleukin_17	86,100	CD8	15,18	interleukin 17	CD8	3605	925	Gene	Gene	Foxp3|appos|START_ENTITY granzyme_B|appos|Foxp3 expressed|nsubj|granzyme_B expressed|dep|cells cells|nsubj|cells cells|compound|END_ENTITY	Peripheral CD4 + CD8 + cells are the activated T cells expressed granzyme_B -LRB- GrB -RRB- , Foxp3 , interleukin_17 -LRB- IL-17 -RRB- , at higher levels in Th1/Th2 cytokines .
19210369	0	interleukin_17A	21,36	IL17A	38,43	interleukin 17A	IL17A	3605	3605	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The polymorphisms of interleukin_17A -LRB- IL17A -RRB- gene and its association with pediatric asthma in Taiwanese population .
22025620	0	interleukin_17A	58,73	cAMP-responsive_element_modulator	0,33	interleukin 17A	cAMP-responsive element modulator	3605	1390	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	cAMP-responsive_element_modulator -LRB- CREM -RRB- a protein induces interleukin_17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic_lupus_erythematosus .
21628458	0	interleukin_17C	46,61	Tumor_necrosis_factor	0,21	interleukin 17C	Tumor necrosis factor	27189	7124	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Tumor_necrosis_factor a-mediated induction of interleukin_17C in human keratinocytes is controlled by nuclear factor kB .
18498295	0	interleukin_1_alpha	63,82	IL-1_alpha	84,94	interleukin 1 alpha	IL-1 alpha	3552	3552	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Complex effects of IL1A polymorphism and calpain inhibitors on interleukin_1_alpha -LRB- IL-1_alpha -RRB- mRNA levels and secretion of IL-1_alpha protein .
3265409	0	interleukin_1_alpha	38,57	IL-1_alpha	59,69	interleukin 1 alpha	IL-1 alpha	3552	3552	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization of the human interleukin_1_alpha -LRB- IL-1_alpha -RRB- gene .
12453471	0	interleukin_1_alpha	58,77	IL-1alpha	79,88	interleukin 1 alpha	IL-1alpha	3552	3552	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel regulatory element in the human interleukin_1_alpha -LRB- IL-1alpha -RRB- gene promoter .
1976521	0	interleukin_1_alpha	115,134	Thy-1	50,55	interleukin 1 alpha	Thy-1	16175(Tax:10090)	21838(Tax:10090)	Gene	Gene	production|amod|START_ENTITY enhancement|nmod|production expression|dep|enhancement expression|nmod|interleukin_1_alpha interleukin_1_alpha|nmod|+ +|compound|END_ENTITY	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
1976521	0	interleukin_1_alpha	27,46	Thy-1	50,55	interleukin 1 alpha	Thy-1	16175(Tax:10090)	21838(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
3494061	0	interleukin_1_alpha	62,81	colony_stimulating_factor	13,38	interleukin 1 alpha	colony stimulating factor	3552	1437	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of colony_stimulating_factor in vivo by recombinant interleukin_1_alpha and recombinant tumor_necrosis_factor_alpha 1 .
7476020	0	interleukin_1_alpha	14,33	interleukin_1_beta_and_interleukin_1_receptor	35,80	interleukin 1 alpha	interleukin 1 beta and interleukin 1 receptor	16175(Tax:10090)	16176(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Expression of interleukin_1_alpha , interleukin_1_beta_and_interleukin_1_receptor antagonist mRNA in mouse brain : regulation by bacterial lipopolysaccharide -LRB- LPS -RRB- treatment .
1976521	0	interleukin_1_alpha	115,134	tumor_necrosis_factor-alpha	149,176	interleukin 1 alpha	tumor necrosis factor-alpha	16175(Tax:10090)	21926(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
1976521	0	interleukin_1_alpha	27,46	tumor_necrosis_factor-alpha	149,176	interleukin 1 alpha	tumor necrosis factor-alpha	16175(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|enhancement enhancement|nmod|production production|nmod|END_ENTITY	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
7962445	0	interleukin_1_and_placental_protein_14	77,115	interleukin_6	49,62	interleukin 1 and placental protein 14	interleukin 6	3552;5047	3569	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Stimulation of human endometrial epithelial cell interleukin_6 production by interleukin_1_and_placental_protein_14 .
19052845	0	interleukin_1_beta	22,40	ADAMTS9	0,7	interleukin 1 beta	ADAMTS9	3553	56999	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	ADAMTS9 activation by interleukin_1_beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes .
11288134	0	interleukin_1_beta	28,46	IL-1_beta	48,57	interleukin 1 beta	IL-1 beta	3553	3553	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Allergen-induced changes in interleukin_1_beta -LRB- IL-1_beta -RRB- mRNA expression by human blood-derived dendritic cells : inter-individual differences and relevance for sensitization testing .
14510824	0	interleukin_1_beta	42,60	IL-1_beta	62,71	interleukin 1 beta	IL-1 beta	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis of a polymorphism of interleukin_1_beta -LRB- IL-1_beta -RRB- gene with temporal_lobe_epilepsy in a Chinese population .
8760825	0	interleukin_1_beta	19,37	IL-1_beta	39,48	interleukin 1 beta	IL-1 beta	3553	3553	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Functional role of interleukin_1_beta -LRB- IL-1_beta -RRB- in IL-1_beta-converting enzyme-mediated apoptosis .
25606396	0	interleukin_1_beta	15,33	IL-1b	35,40	Interleukin 1 beta	IL-1b	3553	3553	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of interleukin_1_beta -LRB- IL-1b -RRB- polymorphism with mRNA expression and risk of non small cell lung_cancer .
11422336	0	interleukin_1_beta	31,49	IL-1beta	51,59	interleukin 1 beta	IL-1beta	3553	3553	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Lack of association between an interleukin_1_beta -LRB- IL-1beta -RRB- gene variation and refractory temporal_lobe_epilepsy .
19043479	0	interleukin_1_beta	56,74	IL1B	76,80	interleukin 1 beta	IL1B	3553	3553	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Association of -31 T > C and -511 _ C > T polymorphisms in the interleukin_1_beta -LRB- IL1B -RRB- promoter in Korean keratoconus patients .
20044070	0	interleukin_1_beta	4,22	IL1B	24,28	interleukin 1 beta	IL1B	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The interleukin_1_beta -LRB- IL1B -RRB- gene is associated with failure to achieve remission and impaired emotion processing in major_depression .
2107652	0	interleukin_1_beta	34,52	Interleukin_6	0,13	interleukin 1 beta	Interleukin 6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Interleukin_6 possibly induced by interleukin_1_beta in the pituitary gland stimulates the release of gonadotropins and prolactin .
1708236	0	interleukin_1_beta	43,61	Transforming_growth_factor_beta_2	0,33	interleukin 1 beta	Transforming growth factor beta 2	24494(Tax:10116)	81809(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta_2 inhibits interleukin_1_beta - and tumour necrosis factor alpha-induction of nitric_oxide synthase in rat renal mesangial cells .
8808791	0	interleukin_1_beta	53,71	interferon-gamma	21,37	interleukin 1 beta	interferon-gamma	24494(Tax:10116)	25712(Tax:10116)	Gene	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Inhibitory effect of interferon-gamma on LPS-induced interleukin_1_beta production by isolated adult rat brain microglia .
1873483	0	interleukin_1_beta	72,90	interleukin_6	10,23	interleukin 1 beta	interleukin 6	24494(Tax:10116)	24498(Tax:10116)	Gene	Gene	hormone|amod|START_ENTITY effect|nmod|hormone production|dep|effect production|amod|END_ENTITY	Augmented interleukin_6 production by rat thyrocytes -LRB- FRTL5 -RRB- : effect of interleukin_1_beta and thyroid-stimulating hormone .
8553267	0	interleukin_1_beta	66,84	macrophage_inflammatory_protein_2	13,46	interleukin 1 beta	macrophage inflammatory protein 2	24494(Tax:10116)	114105(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of macrophage_inflammatory_protein_2 gene expression by interleukin_1_beta in rat lung .
7476020	0	interleukin_1_beta_and_interleukin_1_receptor	35,80	interleukin_1_alpha	14,33	interleukin 1 beta and interleukin 1 receptor	interleukin 1 alpha	16176(Tax:10090)	16175(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Expression of interleukin_1_alpha , interleukin_1_beta_and_interleukin_1_receptor antagonist mRNA in mouse brain : regulation by bacterial lipopolysaccharide -LRB- LPS -RRB- treatment .
9371760	0	interleukin_1_receptor_accessory_protein	67,107	IRAK	15,19	interleukin 1 receptor accessory protein	IRAK	3556	3654	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|Recruitment Recruitment|nmod|END_ENTITY	Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin_1_receptor_accessory_protein .
11752505	0	interleukin_1_receptor_antagonist	26,59	IL-1Ra	61,67	interleukin 1 receptor antagonist	IL-1Ra	3557	3557	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism within the interleukin_1_receptor_antagonist -LRB- IL-1Ra -RRB- gene is associated with ankylosing_spondylitis .
24952603	0	interleukin_1_receptor_antagonist	15,48	IL1RN	50,55	interleukin 1 receptor antagonist	IL1RN	3557	3557	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of interleukin_1_receptor_antagonist -LRB- IL1RN -RRB- gene polymorphism with recurrent pregnancy_loss risk in the North Indian Population and a meta-analysis .
18423886	0	interleukin_1_receptor_antagonist	20,53	IL1Ra	55,60	interleukin 1 receptor antagonist	IL1Ra	3557	3557	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the interleukin_1_receptor_antagonist -LRB- IL1Ra -RRB- gene and placental_abruption .
9224627	0	interleukin_1alpha	88,106	EL4	110,113	interleukin 1alpha	EL4	16175(Tax:10090)	111979(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Staurosporine , but not Ro_31-8220 , induces interleukin_2 production and synergizes with interleukin_1alpha in EL4 thymoma cells .
8772198	0	interleukin_1alpha	131,149	TNFalpha	186,194	interleukin 1alpha	TNFalpha	3552	7124	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|effect effect|nmod|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- induces pro-matrix_metalloproteinase_9 production in human uterine cervical fibroblasts but interleukin_1alpha antagonizes the inductive effect of TNFalpha .
9632078	0	interleukin_1alpha	79,97	cyclooxygenase-2	14,30	interleukin 1alpha	cyclooxygenase-2	281250(Tax:9913)	282023(Tax:9913)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin_1alpha , tumor_necrosis_factor-alpha , glucocorticoids , and 17beta-estradiol .
10049521	0	interleukin_1alpha	34,52	interleukin_6	15,28	interleukin 1alpha	interleukin 6	3552	3569	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of interleukin_6 with interleukin_1alpha in human mammary tumours , but not with oestrogen receptor expression .
11156550	0	interleukin_1alpha	51,69	oncostatin_M	90,102	interleukin 1alpha	oncostatin M	3552	5008	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Esculetin inhibits cartilage resorption induced by interleukin_1alpha in combination with oncostatin_M .
11171688	0	interleukin_1alpha	207,225	oncostatin_M	174,186	interleukin 1alpha	oncostatin M	281250(Tax:9913)	319086(Tax:9913)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Insulin-like_growth_factor_1 blocks collagen release and down regulates matrix_metalloproteinase-1 , _ -3 , _ -8 , _ and _ -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin_M in combination with interleukin_1alpha .
23437386	0	interleukin_1b	74,88	cold-inducible_RNA_binding_protein	25,59	interleukin 1b	cold-inducible RNA binding protein	3553	1153	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	NF-kB-dependent role for cold-inducible_RNA_binding_protein in regulating interleukin_1b .
23223231	0	interleukin_1b	54,68	xylosyltransferase_I	14,34	interleukin 1b	xylosyltransferase I	3553	64131	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of xylosyltransferase_I gene expression by interleukin_1b in human primary chondrocyte cells : mechanism and impact on proteoglycan synthesis .
14760803	0	interleukin_1beta	93,110	ADAMTS-1	0,8	interleukin 1beta	ADAMTS-1	3553	9510	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nsubjpass|END_ENTITY	ADAMTS-1 , a gene product of articular chondrocytes in vivo and in vitro , is downregulated by interleukin_1beta .
9403532	0	interleukin_1beta	78,95	Complement_C3	0,13	interleukin 1beta	Complement C3	3553	718	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Complement_C3 production in human intestinal epithelial cells is regulated by interleukin_1beta and tumor_necrosis_factor_alpha .
9351511	0	interleukin_1beta	40,57	GTP_cyclohydrolase_I	98,118	interleukin 1beta	GTP cyclohydrolase I	24494(Tax:10116)	29244(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Differential effect of dexamethasone on interleukin_1beta - and cyclic_AMP-triggered expression of GTP_cyclohydrolase_I in rat renal mesangial cells .
19914905	0	interleukin_1beta	23,40	Hes1	0,4	interleukin 1beta	Hes1	16176(Tax:10090)	15205(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Hes1 , a new target for interleukin_1beta in chondrocytes .
11025451	0	interleukin_1beta	75,92	MRP1	13,17	interleukin 1beta	MRP1	3553	4363	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of MRP1 and gamma-glutamylcysteine_synthetase gene expression by interleukin_1beta is mediated by nitric_oxide-related signalings in human colorectal_cancer cells .
15930287	0	interleukin_1beta	29,46	adrenomedullin	98,112	interleukin 1beta	adrenomedullin	3553	133	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|END_ENTITY	The proinflammatory cytokine interleukin_1beta and hypoxia cooperatively induce the expression of adrenomedullin in ovarian_carcinoma cells through hypoxia_inducible_factor_1 activation .
3091378	0	interleukin_2	13,26	B_cell_activation	57,74	interleukin 2	B cell activation	3558	29760	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of interleukin_2 and interferon-gamma in human B_cell_activation , growth and differentiation .
9670041	0	interleukin_2	96,109	CD25	4,8	interleukin 2	CD25	16183(Tax:10090)	16184(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibiting|dobj|production suppress|advcl|inhibiting T|ccomp|suppress T|nsubj|+ +|compound|END_ENTITY	CD4 + CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin_2 production .
7539104	0	interleukin_2	14,27	CD28	47,51	interleukin 2	CD28	16183(Tax:10090)	12487(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of interleukin_2 gene expression by CD28 costimulation in mouse T-cell clones : both nuclear and cytoplasmic RNAs are regulated with complex kinetics .
12200381	0	interleukin_2	34,47	CD4	126,129	interleukin 2	CD4	3558	920	Gene	Gene	therapy|amod|START_ENTITY effects|nmod|therapy effects|dep|characterization characterization|nmod|subset subset|nmod|END_ENTITY	Long-term effects of intermittent interleukin_2 therapy in patients with HIV_infection : characterization of a novel subset of CD4 -LRB- + -RRB- / CD25 -LRB- + -RRB- T cells .
15206062	0	interleukin_2	45,58	CD4	0,3	interleukin 2	CD4	3558	920	Gene	Gene	doses|nmod|START_ENTITY response|nmod|doses response|compound|END_ENTITY	CD4 cell response to 3 doses of subcutaneous interleukin_2 : meta-analysis of 3 Vanguard studies .
1531787	0	interleukin_2	47,60	CD4	0,3	interleukin 2	CD4	3558	920	Gene	Gene	responsiveness|amod|START_ENTITY modulate|dobj|responsiveness modulate|nsubj|cells cells|nummod|+ +|compound|END_ENTITY	CD4 + CD45RA + T cells modulate allergen-induced interleukin_2 responsiveness in human lymphocytes .
1534818	0	interleukin_2	41,54	CD4	8,11	interleukin 2	CD4	3558	920	Gene	Gene	receptor|amod|START_ENTITY induction|nmod|receptor molecule|nmod|induction molecule|nummod|END_ENTITY	Role of CD4 molecule in the induction of interleukin_2 and interleukin_2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones .
1608966	0	interleukin_2	21,34	CD4	0,3	interleukin 2	CD4	3558	920	Gene	Gene	responses|amod|START_ENTITY regulate|dobj|responses regulate|nsubj|END_ENTITY	CD4 and CD8 regulate interleukin_2 responses of T cells .
16760795	0	interleukin_2	133,146	CD4	33,36	interleukin 2	CD4	3558	920	Gene	Gene	/|dep|START_ENTITY interruption|nmod|/ count|nmod|interruption count|nsubj|study study|acl|evaluating evaluating|nmod|T-cell T-cell|compound|END_ENTITY	A pilot study evaluating time to CD4 T-cell count < 350 cells/mm -LRB- 3 -RRB- after treatment interruption following antiretroviral therapy + / - interleukin_2 : results of ACTG A5102 .
17274112	0	interleukin_2	119,132	CD4	0,3	interleukin 2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	delivery|nmod|START_ENTITY promote|nmod|delivery promote|nsubj|cells cells|compound|END_ENTITY	CD4 + Th1 cells promote CD8 + Tc1 cell survival , memory response , tumor localization and therapy by targeted delivery of interleukin_2 via acquired pMHC I complexes .
1836455	0	interleukin_2	129,142	CD4	57,60	interleukin 2	CD4	3558	920	Gene	Gene	antibody|nmod|START_ENTITY induced|nmod|antibody induced|nsubj|activity activity|nmod|cells cells|compound|END_ENTITY	Bispecific antibody-directed antitumor activity of human CD4 + helper/killer T cells induced by anti-CD3 monoclonal antibody plus interleukin_2 .
1902447	0	interleukin_2	68,81	CD4	131,134	interleukin 2	CD4	3558	920	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|cells cells|compound|END_ENTITY	Macrophage-T cell interaction is essential for the induction of p75 interleukin_2 -LRB- IL-2 -RRB- _ receptor and IL-2 responsiveness in human CD4 + T cells .
1908085	0	interleukin_2	32,45	CD4	84,87	interleukin 2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Production of interferon_gamma , interleukin_2 , interleukin_4 , and interleukin_10 by CD4 + lymphocytes in vivo during healing and progressive murine leishmaniasis .
2149068	0	interleukin_2	61,74	CD4	15,18	interleukin 2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	responsiveness|nmod|START_ENTITY show|dobj|responsiveness mature|ccomp|show mature|nsubj|+ +|compound|END_ENTITY	Neonatal mouse CD4 + mature thymocytes show responsiveness to interleukin_2 and interleukin_7 : growth in vitro of negatively selected V beta 6 - and V beta 11-expressing CD4 + cells from -LRB- C57BL/6 x DBA/2 -RRB- F1 mice .
2315327	0	interleukin_2	124,137	CD4	91,94	interleukin 2	CD4	3558	920	Gene	Gene	mRNA|amod|START_ENTITY inhibiting|dobj|mRNA produces|advcl|inhibiting produces|dobj|defects defects|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 produces immune defects in CD4 + T lymphocytes by inhibiting interleukin_2 mRNA .
2511620	0	interleukin_2	16,29	CD4	65,68	interleukin 2	CD4	3558	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Mitogen-induced interleukin_2 and gamma interferon production by CD4 + and CD8 + cells of patients with inflammatory arthritides .
2901965	0	interleukin_2	13,26	CD4	75,78	interleukin 2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	lysis|amod|START_ENTITY lysis|nmod|END_ENTITY	Low doses of interleukin_2 induce bystander cell lysis by antigen-specific CD4 + inflammatory T cell clones in short-term assay .
2961571	0	interleukin_2	22,35	CD4	114,117	interleukin 2	CD4	3558	920	Gene	Gene	production|nmod|START_ENTITY synthesis|nsubj|production synthesis|nmod|cells cells|compound|END_ENTITY	Reduced production of interleukin_2 and interferon-gamma and enhanced helper activity for IgG synthesis by cloned CD4 + T cells from patients with AIDS .
2970968	0	interleukin_2	89,102	CD4	21,24	interleukin 2	CD4	3558	920	Gene	Gene	produce|dobj|START_ENTITY differing|xcomp|produce subsets|acl|differing subsets|nmod|cells cells|compound|END_ENTITY	Two subsets of human CD4 + T helper cells differing in kinetics and capacities to produce interleukin_2 and interferon-gamma can be defined by the Leu-18 and UCHL1 monoclonal antibodies .
3106067	0	interleukin_2	105,118	CD4	148,151	interleukin 2	CD4	3558	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin_2 receptor expression in human CD4 and CD8 T cells .
8434390	1	interleukin_2	206,219	CD4	128,131	interleukin 2	CD4	116562(Tax:10116)	24932(Tax:10116)	Gene	Gene	+|nmod|START_ENTITY +|nsubj|Dependence Dependence|nmod|END_ENTITY	V. Dependence of CD4 + suppressor cells on the presence of alloantigen and cytokines , including interleukin_2 .
9670041	0	interleukin_2	96,109	CD4	0,3	interleukin 2	CD4	16183(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibiting|dobj|production suppress|advcl|inhibiting T|ccomp|suppress T|nsubj|+ +|compound|END_ENTITY	CD4 + CD25 + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin_2 production .
1533569	0	interleukin_2	42,55	CD69	86,90	interleukin 2	CD69	3558	969	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Different sensitivity to interleukin_4 of interleukin_2 - and interferon alpha-induced CD69 antigen expression in human resting NK cells and CD3 + , CD4 - , CD8 - lymphocytes .
1383217	0	interleukin_2	41,54	Calcitonin_gene-related_peptide	0,31	interleukin 2	Calcitonin gene-related peptide	16183(Tax:10090)	12310(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Calcitonin_gene-related_peptide inhibits interleukin_2 production by murine T lymphocytes .
15640801	0	interleukin_2	124,137	Foxp3	52,57	interleukin 2	Foxp3	3558	50943	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin_2 .
16242788	0	interleukin_2	21,34	IL-2	36,40	interleukin 2	IL-2	3558	3558	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Potentiating role of interleukin_2 -LRB- IL-2 -RRB- receptors in the midbrain periaqueductal gray -LRB- PAG -RRB- upon defensive rage behavior in the cat : role of neurokinin NK -LRB- 1 -RRB- _ receptors .
1854252	0	interleukin_2	20,33	IL-2	35,39	interleukin 2	IL-2	3558	3558	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Randomized study of interleukin_2 -LRB- IL-2 -RRB- alone vs IL-2 plus lymphokine-activated killer cells for treatment of melanoma and renal_cell_cancer .
2450841	0	interleukin_2	27,40	IL-2	111,115	interleukin 2	IL-2	3558	3558	Gene	Gene	regulation|nmod|START_ENTITY _|nsubj|regulation _|nmod|END_ENTITY	Differential regulation of interleukin_2 -LRB- IL-2 -RRB- _ receptor expression on antigen-specific human T cell clones by IL-2 .
2591452	0	interleukin_2	6,19	IL-2	21,25	interleukin 2	IL-2	3558	3558	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum interleukin_2 -LRB- IL-2 -RRB- levels and prolactin bioactive/radioimmunoassay ratios of women at risk for breast_cancer .
3119713	0	interleukin_2	19,32	IL-2	57,61	interleukin 2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Internalization of interleukin_2 -LRB- IL-2 -RRB- by high affinity IL-2 receptors is required for the growth of IL-2-dependent T cell lines .
3924455	0	interleukin_2	48,61	IL-2	63,67	interleukin 2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Characterization of a monoclonal rat anti-mouse interleukin_2 -LRB- IL-2 -RRB- receptor antibody and its use in the biochemical characterization of the murine IL-2 receptor .
6600395	0	interleukin_2	67,80	IL-2	82,86	interleukin 2	IL-2	3558	3558	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Clearance rates and systemic effects of intravenously administered interleukin_2 -LRB- IL-2 -RRB- containing preparations in human subjects .
7568005	0	interleukin_2	21,34	IL-2	36,40	interleukin 2	IL-2	3558	3558	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Critical role of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc , but not bcl-2 , gene induction .
8035820	0	interleukin_2	63,76	IL-2	78,82	interleukin 2	IL-2	3558	3558	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Evidence for a critical role for the cytoplasmic region of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma chain in IL-2 , IL-4 , and IL-7 signalling .
8473495	0	interleukin_2	45,58	IL-2	60,64	interleukin 2	IL-2	3558	3558	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Negative transcriptional regulation of human interleukin_2 -LRB- IL-2 -RRB- gene by glucocorticoids through interference with nuclear transcription factors AP-1 and NF-AT .
8662742	0	interleukin_2	77,90	IL-2	92,96	interleukin 2	IL-2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin_2 -LRB- IL-2 -RRB- expression in the murine T-cell line , EL4.IL-2 .
2105168	0	interleukin_2	50,63	IL-2_receptor	79,92	interleukin 2	IL-2 receptor	3558	3560	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	1,25-Dihydroxyvitamin _ D3 modulates the effects of interleukin_2 independent of IL-2_receptor binding .
1999222	0	interleukin_2	36,49	IL_2	51,55	interleukin 2	IL 2	3558	3558	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	T cell activation in the absence of interleukin_2 -LRB- IL_2 -RRB- results in the induction of high-affinity IL_2 receptor unable to transmit a proliferative signal .
2973414	0	interleukin_2	42,55	IL_2	57,61	interleukin 2	IL 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Comparison of the structure of the murine interleukin_2 -LRB- IL_2 -RRB- receptor on cytotoxic and helper T cell lines by chemical cross-linking of 125I-labeled IL_2 .
3876375	0	interleukin_2	14,27	IL_2	29,33	interleukin 2	IL 2	3558	3558	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of interleukin_2 -LRB- IL_2 -RRB- by salivary gland lymphocytes in Sj __ gren 's _ syndrome .
2867114	0	interleukin_2	64,77	Interferon-gamma	0,16	interleukin 2	Interferon-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	dependence|nmod|START_ENTITY induction|dep|dependence induction|amod|END_ENTITY	Interferon-gamma induction by lipopolysaccharide : dependence on interleukin_2 and macrophages .
3084288	0	interleukin_2	50,63	Interferon-gamma	0,16	interleukin 2	Interferon-gamma	3558	3458	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Interferon-gamma induces light chain synthesis in interleukin_2 stimulated human B cells .
3102253	0	interleukin_2	43,56	Interferon-gamma	0,16	interleukin 2	Interferon-gamma	3558	3458	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene induces|dobj|expression induces|nsubj|END_ENTITY	Interferon-gamma induces expression of the interleukin_2 receptor gene in human monocytes .
2542734	0	interleukin_2	28,41	Interleukin_1	0,13	interleukin 2	Interleukin 1	3558	3552	Gene	Gene	activation|amod|START_ENTITY regulation|nmod|activation regulation|amod|END_ENTITY	Interleukin_1 regulation of interleukin_2 and interferon-gamma gene activation in a human leukemic HSB .2 subclone .
2578047	0	interleukin_2	115,128	Interleukin_1	0,13	interleukin 2	Interleukin 1	3558	3552	Gene	Gene	distinct|nmod|START_ENTITY requires|xcomp|distinct requires|nsubj|production production|amod|END_ENTITY	Interleukin_1 production by the human monocyte cell line U937 requires a lymphokine induction signal distinct from interleukin_2 or interferons .
7917907	0	interleukin_2	35,48	Interleukin_1_beta	0,18	interleukin 2	Interleukin 1 beta	3558	3553	Gene	Gene	synergises|nmod|START_ENTITY synergises|nsubj|END_ENTITY	Interleukin_1_beta synergises with interleukin_2 in the outgrowth of autologous_tumour-reactive CD8 + effectors .
3000665	2	interleukin_2	127,140	Interleukin_2	39,52	interleukin 2	Interleukin 2	3558	3558	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin_2 receptor_and_transferrin_receptor expression on T cells and production of interleukin_2 in patients with acquired_immune_deficiency_syndrome -LRB- AIDS -RRB- and AIDS-related_complex .
1419905	0	interleukin_2	28,41	NF-kappa_B	14,24	interleukin 2	NF-kappa B	3558	4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of NF-kappa_B by interleukin_2 in human blood monocytes .
9207119	0	interleukin_2	114,127	SH2-domain-containing_leukocyte_protein_76	57,99	interleukin 2	SH2-domain-containing leukocyte protein 76	3558	3937	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing_leukocyte_protein_76 and modulates interleukin_2 production .
9520455	0	interleukin_2	72,85	SHP-1	104,109	interleukin 2	SHP-1	3558	5777	Gene	Gene	receptor|amod|START_ENTITY SHP-1|nmod|receptor Recruitment|nmod|SHP-1 Recruitment|dep|loss loss|nmod|expression expression|compound|END_ENTITY	Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin_2 receptor ; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells .
9520455	0	interleukin_2	72,85	SHP-1	59,64	interleukin 2	SHP-1	3558	5777	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin_2 receptor ; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells .
10497204	0	interleukin_2	105,118	SLP-76	81,87	interleukin 2	SLP-76	3558	3937	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Novel isoform of lymphoid adaptor FYN-T-binding_protein -LRB- FYB-130 -RRB- interacts with SLP-76 and up-regulates interleukin_2 production .
3099287	0	interleukin_2	138,151	Tac_antigen	42,53	interleukin 2	Tac antigen	3558	3559	Gene	Gene	receptor|amod|START_ENTITY conformation|nmod|receptor essential|nmod|conformation essential|nsubj|sites sites|nmod|END_ENTITY	Intracytoplasmic phosphorylation sites of Tac_antigen -LRB- p55 -RRB- are not essential for the conformation , function , and regulation of the human interleukin_2 receptor .
17274112	0	interleukin_2	119,132	Th1	5,8	interleukin 2	Th1	16183(Tax:10090)	57314(Tax:10090)	Gene	Gene	delivery|nmod|START_ENTITY promote|nmod|delivery promote|nsubj|cells cells|compound|END_ENTITY	CD4 + Th1 cells promote CD8 + Tc1 cell survival , memory response , tumor localization and therapy by targeted delivery of interleukin_2 via acquired pMHC I complexes .
7559621	0	interleukin_2	83,96	Vav	148,151	interleukin 2	Vav	3558	7409	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Distinct isoforms of the CD45 protein-tyrosine phosphatase differentially regulate interleukin_2 secretion and activation signal pathways involving Vav in T cells .
1549560	0	interleukin_2	24,37	c-fos	0,5	interleukin 2	c-fos	3558	2353	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	c-fos gene induction by interleukin_2 : identification of the critical cytoplasmic regions within the interleukin_2 receptor beta chain .
7568005	0	interleukin_2	21,34	c-fos	99,104	interleukin 2	IL-2R	3558	3559	Gene	Gene	receptor|amod|START_ENTITY role|nmod|receptor gamma-chain-associated|nsubj|role gamma-chain-associated|nmod|induction induction|amod|END_ENTITY	Critical role of the interleukin_2 -LRB- IL-2 -RRB- receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc , but not bcl-2 , gene induction .
10491027	0	interleukin_2	58,71	erythropoietin	18,32	interleukin 2	erythropoietin	3558	2056	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Recombinant human erythropoietin stimulates production of interleukin_2 by whole blood cell cultures of hemodialysis patients .
7850804	0	interleukin_2	191,204	gamma-interferon	42,58	interleukin 2	gamma-interferon	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	immunotherapy|amod|START_ENTITY increases|nmod|immunotherapy increases|nsubj|mice mice|nmod|END_ENTITY	Treating_tumor-bearing mice with low-dose gamma-interferon plus tumor_necrosis_factor_alpha to diminish immune suppressive granulocyte-macrophage progenitor cells increases responsiveness to interleukin_2 immunotherapy .
2842093	0	interleukin_2	11,24	gp_120	58,64	interleukin 2	gp 120	3558	3700	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of interleukin_2 and large envelope glycoprotein -LRB- gp_120 -RRB- of human_immunodeficiency_virus -LRB- HIV -RRB- on lymphocyte proliferative responses to cytomegalovirus .
2953804	0	interleukin_2	13,26	granulocyte-macrophage_colony-stimulating_factor	74,122	interleukin 2	granulocyte-macrophage colony-stimulating factor	16183(Tax:10090)	12981(Tax:10090)	Gene	Gene	/|nummod|START_ENTITY interleukin_4-dependent|nmod:npmod|/ line|amod|interleukin_4-dependent Growth|nmod|line induced|nsubj|Growth induced|nmod|END_ENTITY	Growth of an interleukin_2 / interleukin_4-dependent T cell line induced by granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- .
8425202	0	interleukin_2	185,198	granulocyte-macrophage_colony-stimulating_factor	127,175	interleukin 2	granulocyte-macrophage colony-stimulating factor	3558	1437	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Functional expression of interleukin_2 receptor in a human factor-dependent megakaryoblastic_leukemia cell line : evidence that granulocyte-macrophage_colony-stimulating_factor inhibits interleukin_2 binding to its receptor .
8425202	0	interleukin_2	25,38	granulocyte-macrophage_colony-stimulating_factor	127,175	interleukin 2	granulocyte-macrophage colony-stimulating factor	3558	1437	Gene	Gene	receptor|amod|START_ENTITY expression|nmod|receptor expression|dep|evidence evidence|dep|inhibits inhibits|nsubj|END_ENTITY	Functional expression of interleukin_2 receptor in a human factor-dependent megakaryoblastic_leukemia cell line : evidence that granulocyte-macrophage_colony-stimulating_factor inhibits interleukin_2 binding to its receptor .
6425204	0	interleukin_2	106,119	granulocyte-macrophage_colony_stimulating_factor	38,86	interleukin 2	granulocyte-macrophage colony stimulating factor	3558	1437	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Production of five human lymphokines -LRB- granulocyte-macrophage_colony_stimulating_factor , interferon-gamma , interleukin_2 , macrophage cytotoxicity factor and macrophage_migration_inhibitory_factor -RRB- from Con A stimulated lymphocyte cultures in bioreactors .
3082984	0	interleukin_2	49,62	homodimer	29,38	interleukin 2	homodimer	3558	6647	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	A 44 kilodalton cell surface homodimer regulates interleukin_2 production by activated human T lymphocytes .
2692401	0	interleukin_2	39,52	insulin	10,17	interleukin 2	insulin	3558	3630	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effect of insulin on the production of interleukin_2 by T lymphocytes .
2105837	0	interleukin_2	65,78	interferon-gamma	119,135	interleukin 2	interferon-gamma	16183(Tax:10090)	15978(Tax:10090)	Gene	Gene	state|nmod|START_ENTITY Maintenance|nmod|state Maintenance|dep|dependence dependence|nmod|interleukin_2 interleukin_2|nmod|END_ENTITY	Maintenance and cure of the L5178Y murine tumor-dormant state by interleukin_2 : dependence of interleukin_2 on induced interferon-gamma and on tumor_necrosis_factor for its antitumor effects .
2424621	0	interleukin_2	37,50	interferon-gamma	70,86	interleukin 2	interferon-gamma	3558	3458	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The direct effects of interleukin_1 , interleukin_2 , interferon-alpha , interferon-gamma , B-cell growth factor , and a B-cell_differentiation_factor on resting and activated human B cells .
2944612	0	interleukin_2	66,79	interferon-gamma	19,35	interleukin 2	interferon-gamma	3558	3458	Gene	Gene	synthesis|amod|START_ENTITY suppression|nmod|synthesis production|nmod|suppression production|amod|END_ENTITY	Histamine inhibits interferon-gamma production via suppression of interleukin_2 synthesis .
2984283	0	interleukin_2	57,70	interferon-gamma	101,117	interleukin 2	interferon-gamma	3558	3458	Gene	Gene	cells|nmod|START_ENTITY cells|nmod|END_ENTITY	Generation of activated killer -LRB- AK -RRB- cells by recombinant interleukin_2 -LRB- rIL_2 -RRB- in collaboration with interferon-gamma -LRB- IFN-gamma -RRB- .
3139787	0	interleukin_2	20,33	interferon-gamma	112,128	interleukin 2	interferon-gamma	3558	3458	Gene	Gene	augmentation|amod|START_ENTITY Characterization|nmod|augmentation Characterization|nmod|DNA DNA|amod|END_ENTITY	Characterization of interleukin_2 and phorbol_myristate_acetate augmentation of expression of transfected human interferon-gamma genomic DNA .
6425204	0	interleukin_2	106,119	interferon-gamma	88,104	interleukin 2	interferon-gamma	3558	3458	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Production of five human lymphokines -LRB- granulocyte-macrophage_colony_stimulating_factor , interferon-gamma , interleukin_2 , macrophage cytotoxicity factor and macrophage_migration_inhibitory_factor -RRB- from Con A stimulated lymphocyte cultures in bioreactors .
2104213	0	interleukin_2	168,181	interleukin_1	185,198	interleukin 2	interleukin 1	3558	3552	Gene	Gene	START_ENTITY|nmod|-LSB- -LSB-|amod|END_ENTITY	Accessory cell-derived helper signals in human T-cell activation with phytohemagglutinin : induction of interleukin_2-responsiveness by interleukin_6 , and production of interleukin_2 by interleukin_1 -LSB- corrected -RSB- .
2424621	0	interleukin_2	37,50	interleukin_1	22,35	interleukin 2	interleukin 1	3558	3552	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The direct effects of interleukin_1 , interleukin_2 , interferon-alpha , interferon-gamma , B-cell growth factor , and a B-cell_differentiation_factor on resting and activated human B cells .
2458871	0	interleukin_2	69,82	interleukin_1	54,67	interleukin 2	interleukin 1	3558	3552	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Multiple_sclerosis : effect of myelin_basic_protein on interleukin_1 , interleukin_2 production and interleukin_2 receptor expression in vitro .
2550707	0	interleukin_2	26,39	interleukin_1	99,112	interleukin 2	interleukin 1	3558	3552	Gene	Gene	production|amod|START_ENTITY inducing|dobj|production pathways|acl|inducing pathways|dep|pathway pathway|amod|END_ENTITY	Two pathways for inducing interleukin_2 production in MOLT_16 cells , a human leukemic_T-cell line : interleukin_1 pathway and interleukin_1-independent pathway .
2783241	0	interleukin_2	48,61	interleukin_1	29,42	interleukin 2	interleukin 1	3558	3552	Gene	Gene	Synergy|nmod|START_ENTITY Synergy|nmod|END_ENTITY	Synergy of human recombinant interleukin_1 with interleukin_2 in the generation of lymphokine-activated killer cells .
3009609	2	interleukin_2	157,170	interleukin_1	111,124	interleukin 2	interleukin 1	3558	3552	Gene	Gene	production|nmod|START_ENTITY downregulates|dobj|production downregulates|nsubj|inhibitor inhibitor|nmod|END_ENTITY	A monocyte-dependent inhibitor of interleukin_1 downregulates the production of interleukin_2 and interferon-gamma in rheumatoid_arthritis .
3090248	0	interleukin_2	37,50	interleukin_1	9,22	interleukin 2	interleukin 1	3558	3552	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Enhanced interleukin_1 and depressed interleukin_2 production in juvenile_arthritis .
3880962	2	interleukin_2	90,103	interleukin_1	62,75	interleukin 2	interleukin 1	3558	3552	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Normal interleukin_1 and defective interleukin_2 production in short-term patients and in those with chronic_graft-versus-host_disease .
3920312	0	interleukin_2	13,26	interleukin_1	81,94	interleukin 2	interleukin 1	16183(Tax:10090)	111343(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY responsiveness|nsubj|Induction responsiveness|nmod|action action|nmod|END_ENTITY	Induction of interleukin_2 responsiveness in thymocytes by synergistic action of interleukin_1 and interleukin_2 .
6235287	0	interleukin_2	168,181	interleukin_1	106,119	interleukin 2	interleukin 1	3558	3552	Gene	Gene	receptors|nmod|START_ENTITY expression|nmod|receptors required|nmod|expression required|nsubjpass|END_ENTITY	Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor : interleukin_1 is required for the expression of receptors for interleukin_2 .
12231521	0	interleukin_2	36,49	interleukin_2	90,103	interleukin 2	interleukin 2	3558	3558	Gene	Gene	START_ENTITY|nmod|therapy therapy|amod|END_ENTITY	Postremission therapy with low-dose interleukin_2 with or without intermediate pulse dose interleukin_2 therapy is well tolerated in elderly patients with acute_myeloid_leukemia : Cancer and Leukemia Group B study 9420 .
12231521	0	interleukin_2	90,103	interleukin_2	36,49	interleukin 2	interleukin 2	3558	3558	Gene	Gene	therapy|amod|START_ENTITY END_ENTITY|nmod|therapy	Postremission therapy with low-dose interleukin_2 with or without intermediate pulse dose interleukin_2 therapy is well tolerated in elderly patients with acute_myeloid_leukemia : Cancer and Leukemia Group B study 9420 .
16707844	0	interleukin_2	74,87	interleukin_2	88,101	interleukin 2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Possible activation of murine T lymphocyte through CD98 is independent of interleukin_2 / interleukin_2 receptor system .
16707844	0	interleukin_2	88,101	interleukin_2	74,87	interleukin 2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Possible activation of murine T lymphocyte through CD98 is independent of interleukin_2 / interleukin_2 receptor system .
2220199	0	interleukin_2	14,27	interleukin_2	46,59	interleukin 2	interleukin 2	3558	3558	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Production of interleukin_2 and expression of interleukin_2 receptors by pony peripheral blood lymphocytes after stimulation with a soluble fraction of Trypanosoma evansi .
2220199	0	interleukin_2	46,59	interleukin_2	14,27	interleukin 2	interleukin 2	3558	3558	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Production of interleukin_2 and expression of interleukin_2 receptors by pony peripheral blood lymphocytes after stimulation with a soluble fraction of Trypanosoma evansi .
2981271	0	interleukin_2	14,27	interleukin_2	31,44	interleukin 2	interleukin 2	3558	3558	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Regulation by interleukin_2 of interleukin_2 receptors and gamma-interferon synthesis by human thymocytes : augmentation of interleukin_2 receptors by interleukin_2 .
2981271	0	interleukin_2	31,44	interleukin_2	14,27	interleukin 2	interleukin 2	3558	3558	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Regulation by interleukin_2 of interleukin_2 receptors and gamma-interferon synthesis by human thymocytes : augmentation of interleukin_2 receptors by interleukin_2 .
3086969	0	interleukin_2	14,27	interleukin_2	51,64	interleukin 2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of interleukin_2 receptor expression by interleukin_2 .
3086969	0	interleukin_2	51,64	interleukin_2	14,27	interleukin 2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of interleukin_2 receptor expression by interleukin_2 .
3114379	1	interleukin_2	109,122	interleukin_2	78,91	interleukin 2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Irreversible cross-linking of radiolabeled interleukin_2 to high affinity interleukin_2 receptors reveals a noncovalently associated subunit .
3114379	1	interleukin_2	78,91	interleukin_2	109,122	interleukin 2	interleukin 2	16183(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Irreversible cross-linking of radiolabeled interleukin_2 to high affinity interleukin_2 receptors reveals a noncovalently associated subunit .
3115640	0	interleukin_2	68,81	interleukin_2	85,98	interleukin 2	interleukin 2	3558	3558	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Corticosteroid-interleukin_2 interactions : inhibition of binding of interleukin_2 to interleukin_2 receptors .
3115640	0	interleukin_2	85,98	interleukin_2	68,81	interleukin 2	interleukin 2	3558	3558	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Corticosteroid-interleukin_2 interactions : inhibition of binding of interleukin_2 to interleukin_2 receptors .
3132735	0	interleukin_2	47,60	interleukin_2	70,83	interleukin 2	interleukin 2	3558	3558	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	-LSB- Biological significance of the interaction of interleukin_2 with the interleukin_2 receptor during development of the immune response -RSB- .
3132735	0	interleukin_2	70,83	interleukin_2	47,60	interleukin 2	interleukin 2	3558	3558	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	-LSB- Biological significance of the interaction of interleukin_2 with the interleukin_2 receptor during development of the immune response -RSB- .
3936041	0	interleukin_2	30,43	interleukin_2	61,74	interleukin 2	interleukin 2	3558	3558	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	Induction and upregulation by interleukin_2 of high-affinity interleukin_2 receptors on thymocytes and T cells .
3936041	0	interleukin_2	61,74	interleukin_2	30,43	interleukin 2	interleukin 2	3558	3558	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	Induction and upregulation by interleukin_2 of high-affinity interleukin_2 receptors on thymocytes and T cells .
1588792	0	interleukin_2	104,117	interleukin_2_receptors	62,85	interleukin 2	interleukin 2 receptors	3558	3559	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Phorbol_myristate_acetate-induced expression of high-affinity interleukin_2_receptors and production of interleukin_2 by human acute_lymphoblastic_leukemia T cells .
2083227	0	interleukin_2	113,126	interleukin_4	145,158	interleukin 2	interleukin 4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Interleukin_7 stimulates growth of fetal thymic precursors of cytolytic cells : induction of effector function by interleukin_2 and inhibition by interleukin_4 .
2174560	0	interleukin_2	27,40	interleukin_4	52,65	interleukin 2	interleukin 4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|dep|END_ENTITY	cAMP inhibits induction of interleukin_2 but not of interleukin_4 in T cells .
3126257	0	interleukin_2	8,21	interleukin_4	23,36	interleukin 2	interleukin 4	16183(Tax:10090)	16189(Tax:10090)	Gene	Gene	beta|amod|START_ENTITY beta|amod|END_ENTITY	Role of interleukin_2 , interleukin_4 , and alpha , beta , and gamma interferon in stimulating macrophage antibody-dependent tumoricidal activity .
8356077	0	interleukin_2	30,43	interleukin_4	67,80	interleukin 2	interleukin 4	3558	3565	Gene	Gene	regulation|nmod|START_ENTITY function|nsubj|regulation function|nmod|END_ENTITY	Molecular regulation of human interleukin_2 and T-cell function by interleukin_4 .
9578118	0	interleukin_2	42,55	interleukin_6	12,25	interleukin 2	interleukin 6	3558	3569	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Increase of interleukin_6 and decrease of interleukin_2 production during the ageing process are influenced by the health status .
9883316	0	interleukin_2	10,23	interleukin_6	34,47	interleukin 2	interleukin 6	3558	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Exogenous interleukin_2 regulates interleukin_6 and nitric_oxide but not interferon gamma and tumor necrosis factor alpha production in bronchoalveolar leukocytes from patients with small cell lung_cancer .
2421884	0	interleukin_2	53,66	lymphokine	41,51	interleukin 2	lymphokine	3558	3558	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization and modulation of human lymphokine -LRB- interleukin_2 -RRB- activated killer cell induction .
2458871	0	interleukin_2	69,82	myelin_basic_protein	30,50	interleukin 2	myelin basic protein	3558	4155	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Multiple_sclerosis : effect of myelin_basic_protein on interleukin_1 , interleukin_2 production and interleukin_2 receptor expression in vitro .
1698909	0	interleukin_2	28,41	p70	70,73	interleukin 2	p70	3558	84959	Gene	Gene	chain|compound|START_ENTITY chain|appos|END_ENTITY	Increased expression of the interleukin_2 -LRB- IL-2 -RRB- receptor beta chain -LRB- p70 -RRB- on CD56 + natural killer cells after in vivo IL-2 therapy : p70 expression does not alone predict the level of intermediate affinity IL-2 binding .
1394125	0	interleukin_2	42,55	p75	38,41	interleukin 2	p75	3558	3560	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression and functional role of the p75 interleukin_2 receptor chain on leukemic hairy_cells .
1691679	0	interleukin_2	34,47	p75	113,116	interleukin 2	p75	3558	3560	Gene	Gene	treatment|amod|START_ENTITY activated|nmod|treatment cells|acl|activated respond|nsubj|cells respond|xcomp|interleukin_2 interleukin_2|nmod|receptor receptor|amod|END_ENTITY	Natural killer cells activated by interleukin_2 treatment in vivo respond to interleukin_2 primarily through the p75 receptor and maintain the p55 -LRB- TAC -RRB- negative phenotype .
1691679	0	interleukin_2	77,90	p75	113,116	interleukin 2	p75	3558	3560	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Natural killer cells activated by interleukin_2 treatment in vivo respond to interleukin_2 primarily through the p75 receptor and maintain the p55 -LRB- TAC -RRB- negative phenotype .
1831304	0	interleukin_2	18,31	p75	53,56	interleukin 2	p75	3558	3560	Gene	Gene	chain|amod|START_ENTITY chain|appos|END_ENTITY	Expression of the interleukin_2 receptor beta chain -LRB- p75 -RRB- in renal transplantation -- applicability of anti-interleukin-2_receptor_beta chain monoclonal antibody .
2319807	0	interleukin_2	53,66	p75	32,35	interleukin 2	p75	3558	3560	Gene	Gene	receptor|amod|START_ENTITY component|nmod|receptor component|amod|END_ENTITY	Human B lymphocytes express the p75 component of the interleukin_2 receptor .
3110786	0	interleukin_2	36,49	p75	4,7	interleukin 2	p75	3558	3560	Gene	Gene	receptor|nmod|START_ENTITY expressed|dep|receptor expressed|nsubjpass|peptide peptide|amod|END_ENTITY	The p75 peptide is the receptor for interleukin_2 expressed on large granular lymphocytes and is responsible for the interleukin_2 activation of these cells .
9816306	0	interleukin_2	17,30	p75	94,97	interleukin 2	p75	3558	3560	Gene	Gene	trial|nmod|START_ENTITY necrosis|nsubj|trial necrosis|dobj|chimera chimera|compound|END_ENTITY	Phase I trial of interleukin_2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera .
2467489	0	interleukin_2	61,74	rIL-2	76,81	interleukin 2	rIL-2	3558	116562(Tax:10116)	Gene	Gene	treated|nmod|START_ENTITY treated|dep|END_ENTITY	A case of cutaneous_T_cell_lymphoma treated with recombinant interleukin_2 -LRB- rIL-2 -RRB- .
2788945	0	interleukin_2	54,67	rIL-2	69,74	interleukin 2	rIL-2	3558	116562(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	A phase II study of the administration of recombinant interleukin_2 -LRB- rIL-2 -RRB- plus lymphokine activated killer -LRB- LAK -RRB- cells in stage IV melanoma patients .
3100633	0	interleukin_2	58,71	rIL_2	73,78	interleukin 2	rIL 2	3558	116562(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Phenotypic and functional characterization of recombinant interleukin_2 -LRB- rIL_2 -RRB- - induced activated killer cells : analysis at the population and clonal levels .
3000665	2	interleukin_2	127,140	receptor_and_transferrin_receptor	53,86	interleukin 2	receptor and transferrin receptor	3558	3558	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Interleukin_2 receptor_and_transferrin_receptor expression on T cells and production of interleukin_2 in patients with acquired_immune_deficiency_syndrome -LRB- AIDS -RRB- and AIDS-related_complex .
12591901	0	interleukin_2	80,93	suppressor_of_cytokine_signaling_3	10,44	interleukin 2	suppressor of cytokine signaling 3	16183(Tax:10090)	12702(Tax:10090)	Gene	Gene	production|amod|START_ENTITY role|nmod|production role|nmod|END_ENTITY	A role of suppressor_of_cytokine_signaling_3 -LRB- SOCS3/CIS3/SSI3 -RRB- in CD28-mediated interleukin_2 production .
2263237	0	interleukin_2	110,123	tumor_necrosis_factor	151,172	interleukin 2	tumor necrosis factor	16183(Tax:10090)	21926(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	-LSB- Induction of lymphokine activated killer -LRB- LAK -RRB- and prolongation of its activity by intrasplenic injection of interleukin_2 -LRB- IL-2 -RRB- in combination with tumor_necrosis_factor -LRB- TNF -RRB- -RSB- .
3121359	0	interleukin_2	45,58	tumor_necrosis_factor	12,33	interleukin 2	tumor necrosis factor	116562(Tax:10116)	103694380	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Recombinant tumor_necrosis_factor can induce interleukin_2 receptor expression and cytolytic activity in a rat x mouse T cell hybrid .
23183096	0	interleukin_20	25,39	IL-20	41,46	interleukin 20	IL-20	50604	50604	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Genetic polymorphisms of interleukin_20 -LRB- IL-20 -RRB- in patients with ulcerative_colitis .
24520124	0	interleukin_21	44,58	Arntl2	34,40	interleukin 21	Arntl2	60505(Tax:10090)	272322(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Linking the circadian rhythm gene Arntl2 to interleukin_21 expression in type 1 diabetes .
15941730	0	interleukin_23	62,76	IL23A	78,83	interleukin 23	IL23A	51561	51561	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin 12 -LRB- IL12B -RRB- , interleukin 12 receptor -LRB- IL12RB1 -RRB- and interleukin_23 -LRB- IL23A -RRB- gene polymorphism in systemic_lupus_erythematosus .
16710719	0	interleukin_24	6,20	IL-24	28,33	interleukin 24	IL-24	11009	11009	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Human interleukin_24 -LRB- MDA-7 / IL-24 -RRB- protein kills breast_cancer cells via the IL-20 receptor and is antagonized by IL-10 .
16710719	0	interleukin_24	6,20	MDA-7	22,27	interleukin 24	MDA-7	11009	11009	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Human interleukin_24 -LRB- MDA-7 / IL-24 -RRB- protein kills breast_cancer cells via the IL-20 receptor and is antagonized by IL-10 .
2968871	2	interleukin_2_receptor	117,139	CD4	148,151	interleukin 2 receptor	CD4	3559	920	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased mitogen-induced expression of interleukin_2_receptor by both CD4 and CD8 cell subsets .
10037026	0	interleukin_2_receptor	100,122	IL2R	124,128	interleukin 2 receptor	IL2R	3559	3559	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin_2_receptor -LRB- IL2R -RRB- system : Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery .
1814846	0	interleukin_2_receptor	27,49	Prothymosin_alpha	0,17	interleukin 2 receptor	Prothymosin alpha	3559	100506248	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Prothymosin_alpha enhances interleukin_2_receptor expression in normal human T-lymphocytes .
2440696	0	interleukin_2_receptor	86,108	p55	67,70	interleukin 2 receptor	p55	16184(Tax:10090)	21937(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin_2_receptor : relationship to the interleukin 2-binding site .
2037012	0	interleukin_2_receptor	96,118	p75	92,95	interleukin 2 receptor	p75	3559	3560	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Human eosinophils from hypereosinophilic patients spontaneously express the p55 but not the p75 interleukin_2_receptor subunit .
2833327	0	interleukin_2_receptor	37,59	p75	22,25	interleukin 2 receptor	p75	3559	3560	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The expression of the p75 subunit of interleukin_2_receptor in Tac negative leukemic cells of two patients with large_granular_lymphocytic_leukemia .
14621914	0	interleukin_2_receptor_b	11,35	P75	43,46	interleukin 2 receptor b	P75	3558	3560	Gene	Gene	chain|amod|START_ENTITY chain|appos|END_ENTITY	Effects of interleukin_2_receptor_b chain -LRB- P75 -RRB- - specific monoclonal antibody on the generation of cytotoxic T lymphocytes and suppressor T cells in mixed lymphocyte culture .
1707657	0	interleukin_2_receptor_beta	31,58	p75	60,63	interleukin 2 receptor beta	p75	3560	3560	Gene	Gene	chain|amod|START_ENTITY chain|appos|END_ENTITY	Differential expression of the interleukin_2_receptor_beta -LRB- p75 -RRB- chain on human peripheral blood natural killer subsets .
1588792	0	interleukin_2_receptors	62,85	interleukin_2	104,117	interleukin 2 receptors	interleukin 2	3559	3558	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Phorbol_myristate_acetate-induced expression of high-affinity interleukin_2_receptors and production of interleukin_2 by human acute_lymphoblastic_leukemia T cells .
6819151	0	interleukin_3	102,115	20_alpha-hydroxysteroid_dehydrogenase	0,37	interleukin 3	20 alpha-hydroxysteroid dehydrogenase	16187(Tax:10090)	105349(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	20_alpha-hydroxysteroid_dehydrogenase expression in hemopoietic cell cultures and its relationship to interleukin_3 .
18432817	0	interleukin_3	15,28	G-CSF	80,85	interleukin 3	G-CSF	3562	1440	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|GM-CSF GM-CSF|appos|END_ENTITY	Measurement of interleukin_3 and other hematopoietic cytokines , such as GM-CSF , G-CSF , M-CSF , erythropoietin , steel_factor , and Flt-3_ligand .
7530467	0	interleukin_3	191,204	G-CSF	114,119	interleukin 3	G-CSF	16187(Tax:10090)	12985(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Induction of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- expression in bone marrow and fractionated marrow cell populations by interleukin_3 -LRB- IL-3 -RRB- : IL-3-mediated positive feedback mechanisms of granulopoiesis .
18432817	0	interleukin_3	15,28	GM-CSF	72,78	interleukin 3	GM-CSF	3562	1437	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|END_ENTITY	Measurement of interleukin_3 and other hematopoietic cytokines , such as GM-CSF , G-CSF , M-CSF , erythropoietin , steel_factor , and Flt-3_ligand .
23226269	0	interleukin_3	4,17	IL3	24,27	interleukin 3	IL3	3562	3562	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The interleukin_3 gene -LRB- IL3 -RRB- contributes to human brain volume variation by regulating proliferation and survival of neural progenitors .
8454603	0	interleukin_3	30,43	IL3	45,48	interleukin 3	IL3	3562	3562	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of interleukin_3 -LRB- IL3 -RRB- in primary human T lymphocytes .
8378315	0	interleukin_3	69,82	Jak2	24,28	interleukin 3	Jak2	16187(Tax:10090)	16452(Tax:10090)	Gene	Gene	transduction|amod|START_ENTITY Structure|nmod|transduction Structure|nmod|kinase kinase|amod|END_ENTITY	Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin_3 signal transduction .
8510934	0	interleukin_3	54,67	Tax	47,50	interleukin 3	Tax	3562	6900	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Differential effect of HTLV_infection and HTLV Tax on interleukin_3 expression .
7684436	0	interleukin_3	44,57	Tumor_necrosis_factor_alpha	0,27	interleukin 3	Tumor necrosis factor alpha	3562	7124	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha cooperates with interleukin_3 in the recruitment of a primitive subset of human CD34 + progenitors .
15988318	0	interleukin_3	89,102	erythropoietin	73,87	interleukin 3	erythropoietin	3562	2056	Gene	Gene	interleukin_6|dep|START_ENTITY interleukin_6|compound|END_ENTITY	Association between nucleated red blood cells in blood and the levels of erythropoietin , interleukin_3 , interleukin_6 , and interleukin 12p70 .
1722396	0	interleukin_3	68,81	erythropoietin	14,28	interleukin 3	erythropoietin	3562	2056	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Growth signal erythropoietin activates the same tyrosine kinases as interleukin_3 , but activates only one tyrosine kinase as differentiation signal .
2844574	0	interleukin_3	89,102	erythropoietin	47,61	interleukin 3	erythropoietin	16187(Tax:10090)	13856(Tax:10090)	Gene	Gene	erythroblasts|nmod|START_ENTITY erythroblasts|nsubj|Down-modulation Down-modulation|nmod|receptors receptors|nmod|END_ENTITY	Down-modulation of high-affinity receptors for erythropoietin on murine erythroblasts by interleukin_3 .
7528591	0	interleukin_3	30,43	erythropoietin	14,28	interleukin 3	erythropoietin	3562	2056	Gene	Gene	Synergy|appos|START_ENTITY Synergy|nmod|END_ENTITY	Synergy among erythropoietin , interleukin_3 , stem_cell_factor -LRB- c-kit_ligand -RRB- and interferon-gamma on early human hematopoiesis .
7530467	0	interleukin_3	191,204	granulocyte_colony-stimulating_factor	75,112	interleukin 3	granulocyte colony-stimulating factor	16187(Tax:10090)	12985(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- expression in bone marrow and fractionated marrow cell populations by interleukin_3 -LRB- IL-3 -RRB- : IL-3-mediated positive feedback mechanisms of granulopoiesis .
3935881	0	interleukin_3	68,81	megakaryocyte_colony_stimulating_factor	7,46	interleukin 3	megakaryocyte colony stimulating factor	16187(Tax:10090)	21832(Tax:10090)	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Murine megakaryocyte_colony_stimulating_factor : its relationship to interleukin_3 .
7504295	0	interleukin_3	17,30	tumor_necrosis_factor_alpha	84,111	interleukin 3	tumor necrosis factor alpha	3562	7124	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	The receptor for interleukin_3 is selectively induced in human endothelial cells by tumor_necrosis_factor_alpha and potentiates interleukin_8 secretion and neutrophil transmigration .
23000728	0	interleukin_33	25,39	IL-33	41,46	interleukin 33	IL-33	90865	90865	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of interleukin_33 -LRB- IL-33 -RRB- in patients with eosinophilic_pneumonia .
20638676	0	interleukin_33	17,31	ST2	44,47	interleukin 33	ST2	90865	6761	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Up-regulation of interleukin_33 and soluble ST2 serum levels in liver_failure .
23585867	0	interleukin_33	8,22	ST2	23,26	interleukin 33	ST2	90865	6761	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	A novel interleukin_33 / ST2 signaling regulates inflammatory response in human corneal epithelium .
26312920	0	interleukin_33	8,22	ST2	23,26	interleukin 33	ST2	90865	6761	Gene	Gene	Role|nmod|START_ENTITY Role|dep|axis axis|nummod|END_ENTITY	Role of interleukin_33 / ST2 axis in the immune-mediated pathogenesis of age-related macular_degeneration .
19996325	0	interleukin_33	42,56	ST2L	83,87	interleukin 33	ST2L	90865	9173	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of interleukin 1-like cytokine interleukin_33 and its receptor complex -LRB- ST2L and IL1RAcP -RRB- in human pancreatic myofibroblasts .
22329990	0	interleukin_33	33,47	Trefoil_factor_2	0,16	interleukin 33	Trefoil factor 2	77125(Tax:10090)	21785(Tax:10090)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Trefoil_factor_2 rapidly induces interleukin_33 to promote type 2 immunity during allergic_asthma and hookworm_infection .
3495433	0	interleukin_4	12,25	BSF-1	26,31	interleukin 4	BSF-1	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|promotes promotes|nsubj|END_ENTITY	Recombinant interleukin_4 / BSF-1 promotes growth and differentiation of intrathymic T cell precursors from fetal mice in vitro .
2958544	0	interleukin_4	39,52	B_cell_stimulatory_factor-1	10,37	interleukin 4	B cell stimulatory factor-1	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of B_cell_stimulatory_factor-1 -LRB- interleukin_4 -RRB- on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines .
3496134	0	interleukin_4	39,52	B_cell_stimulatory_factor-1	11,38	interleukin 4	B cell stimulatory factor-1	3565	3565	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of B_cell_stimulatory_factor-1 / interleukin_4 on hematopoietic_progenitor_cells .
3500217	0	interleukin_4	36,49	B_cell_stimulatory_factor_1	8,35	interleukin 4	B cell stimulatory factor 1	3565	3565	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of B_cell_stimulatory_factor_1 / interleukin_4 in clonal proliferation of B cells .
16051465	0	interleukin_4	11,24	CD25	28,32	interleukin 4	CD25	16189(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Effects of interleukin_4 on CD25 + CD4 + regulatory T cell function .
10377185	0	interleukin_4	42,55	CD4	92,95	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	dominance|amod|START_ENTITY abolished|nsubjpass|dominance abolished|nmod|T T|compound|END_ENTITY	Cure of progressive murine leishmaniasis : interleukin_4 dominance is abolished by transient CD4 -LRB- + -RRB- T cell depletion and T helper cell type 1-selective cytokine therapy .
10720554	0	interleukin_4	24,37	CD4	41,44	interleukin 4	CD4	3565	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Increased production of interleukin_4 by CD4 + and CD8 + T cells from patients with tuberculosis is related to the presence of pulmonary cavities .
10973285	0	interleukin_4	20,33	CD4	61,64	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY alloreactive|nsubj|role alloreactive|dobj|cells cells|compound|END_ENTITY	A critical role for interleukin_4 in activating alloreactive CD4 T cells .
11409116	0	interleukin_4	23,36	CD4	47,50	interleukin 4	CD4	3565	920	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Increased frequency of interleukin_4 producing CD4 + and CD8 + cells in peripheral blood from patients with systemic_sclerosis .
11796615	0	interleukin_4	115,128	CD4	47,50	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	IL-4|amod|START_ENTITY induction|nmod|IL-4 lymphocytes|dep|induction lymphocytes|dep|END_ENTITY	Fas_ligand-expressing B-1a lymphocytes mediate CD4 -LRB- + -RRB- - T-cell apoptosis during schistosomal_infection : induction by interleukin_4 -LRB- IL-4 -RRB- and IL-10 .
1348406	0	interleukin_4	125,138	CD4	16,19	interleukin 4	CD4	3565	920	Gene	Gene	involvement|nmod|START_ENTITY Coexpression|dep|involvement Coexpression|nmod|END_ENTITY	Coexpression of CD4 and CD8 on mitogen-activated peripheral blood T cells from children with asthma : possible involvement of interleukin_4 .
1460418	0	interleukin_4	146,159	CD4	90,93	interleukin 4	CD4	287287(Tax:10116)	24932(Tax:10116)	Gene	Gene	inhibited|nmod|START_ENTITY induce|parataxis|inhibited induce|dobj|expression expression|nmod|chains chains|nmod|cells cells|compound|END_ENTITY	Glucocorticoids induce the expression of CD8_alpha chains on concanavalin A-activated rat CD4 + T cells : induction is inhibited by rat recombinant interleukin_4 .
15579591	0	interleukin_4	131,144	CD4	158,161	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|acl|expressed expressed|nmod|cells cells|compound|END_ENTITY	Contraception in mice immunized with recombinant zona pellucida subunit 3 proteins correlates with Th2 responses and the levels of interleukin_4 expressed by CD4 + cells .
16051465	0	interleukin_4	11,24	CD4	33,36	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Effects of interleukin_4 on CD25 + CD4 + regulatory T cell function .
1908085	0	interleukin_4	47,60	CD4	84,87	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	interleukin_2|nummod|START_ENTITY interleukin_2|nmod|+ +|compound|END_ENTITY	Production of interferon_gamma , interleukin_2 , interleukin_4 , and interleukin_10 by CD4 + lymphocytes in vivo during healing and progressive murine leishmaniasis .
7902409	0	interleukin_4	33,46	CD4	61,64	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|cells cells|compound|END_ENTITY	Allergen immunotherapy decreases interleukin_4 production in CD4 + T cells from allergic individuals .
8524877	0	interleukin_4	108,121	CD4	65,68	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	produce|dobj|START_ENTITY absence|acl:relcl|produce absence|nmod|cells cells|compound|END_ENTITY	Defective IgE production by SJL mice is linked to the absence of CD4 + , _ NK1 .1 + T cells that promptly produce interleukin_4 .
9096368	0	interleukin_4	32,45	CD4	18,21	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY cytokine-autonomous|nsubj|production cytokine-autonomous|nmod|cells cells|compound|END_ENTITY	In differentiated CD4 + T cells , interleukin_4 production is cytokine-autonomous , whereas interferon_gamma production is cytokine-dependent .
9380721	0	interleukin_4	3,16	CD4	48,51	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|dep|mice mice|amod|independent independent|ccomp|revealed revealed|nsubjpass|production production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
9670042	0	interleukin_4	115,128	CD4	0,3	interleukin 4	CD4	3565	920	Gene	Gene	expression|amod|START_ENTITY express|dobj|expression instructs|xcomp|express cytokine|parataxis|instructs cytokine|nsubj|cell cell|compound|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
9670042	0	interleukin_4	115,128	CD4	92,95	interleukin 4	CD4	3565	920	Gene	Gene	expression|amod|START_ENTITY express|dobj|expression instructs|xcomp|express instructs|dobj|cells cells|compound|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
9858515	0	interleukin_4	36,49	CD4	66,69	interleukin 4	CD4	16189(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Genetic regulation of commitment to interleukin_4 production by a CD4 -LRB- + -RRB- T cell-intrinsic mechanism .
9892610	0	interleukin_4	109,122	CD4	189,192	interleukin 4	CD4	287287(Tax:10116)	24932(Tax:10116)	Gene	Gene	START_ENTITY|nmod|prevention prevention|nmod|autoimmune_thyroiditis autoimmune_thyroiditis|nmod|rats rats|nmod|CD45RC CD45RC|compound|END_ENTITY	Regulatory T cells in the control of autoimmunity : the essential role of transforming growth factor beta and interleukin_4 in the prevention of autoimmune_thyroiditis in rats by peripheral CD4 -LRB- + -RRB- CD45RC - cells and CD4 -LRB- + -RRB- CD8 -LRB- - -RRB- thymocytes .
2467815	0	interleukin_4	6,19	CD5	61,64	interleukin 4	CD5	3565	921	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Human interleukin_4 down-regulates the surface expression of CD5 on normal and leukemic B cells .
9482907	0	interleukin_4	25,38	CD81	0,4	interleukin 4	CD81	16189(Tax:10090)	12520(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY promotes|dobj|secretion promotes|nsubj|END_ENTITY	CD81 on B cells promotes interleukin_4 secretion and antibody production during T helper type 2 immune responses .
1460418	0	interleukin_4	146,159	CD8_alpha	41,50	interleukin 4	CD8 alpha	287287(Tax:10116)	24930(Tax:10116)	Gene	Gene	inhibited|nmod|START_ENTITY induce|parataxis|inhibited induce|dobj|expression expression|nmod|chains chains|amod|END_ENTITY	Glucocorticoids induce the expression of CD8_alpha chains on concanavalin A-activated rat CD4 + T cells : induction is inhibited by rat recombinant interleukin_4 .
3500063	0	interleukin_4	32,45	CDw40	61,66	interleukin 4	CDw40	3565	958	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Synergistic interaction between interleukin_4 and anti-Bp50 -LRB- CDw40 -RRB- revealed in a novel B cell restimulation assay .
11101004	0	interleukin_4	50,63	CYP2E1	35,41	interleukin 4	CYP2E1	3565	1571	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	The induction of the human hepatic CYP2E1 gene by interleukin_4 is transcriptional and regulated by protein kinase C. Cytochrome_P4502E1 -LRB- CYP2E1 -RRB- plays a key role in the metabolism of numerous drug substrates , mostly in mammalian liver .
9286385	0	interleukin_4	63,76	Fc_epsilon_RI_alpha	13,32	interleukin 4	Fc epsilon RI alpha	3565	2205	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Induction of Fc_epsilon_RI_alpha mRNA and protein synthesis by interleukin_4 in CD34 + cells-derived CD1a + dendritic cells .
2060018	0	interleukin_4	21,34	IL-4	36,40	interleukin 4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of murine interleukin_4 -LRB- IL-4 -RRB- receptor expression using anti-receptor monoclonal antibodies and S1 nuclease protection analyses .
7504061	0	interleukin_4	3,16	IL-4	18,22	interleukin 4	IL-4	3565	3565	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 -LRB- IgG4 -RRB- and IgE synthesis and B cell proliferation : support for a common component shared by IL-4 and IL-13 receptors .
7807002	0	interleukin_4	23,36	IL-4	38,42	interleukin 4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Characterization of an interleukin_4 -LRB- IL-4 -RRB- responsive region in the immunoglobulin heavy chain germline epsilon promoter : regulation by NF-IL-4 , a C/EBP family member and NF-kappa_B / p50 .
8145047	0	interleukin_4	13,26	IL-4	28,32	interleukin 4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of interleukin_4 -LRB- IL-4 -RRB- expression in T helper -LRB- Th -RRB- cells is not dependent on IL-4 from non-Th cells .
9380721	0	interleukin_4	3,16	IL-4	60,64	interleukin 4	IL-4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	START_ENTITY|dep|mice mice|amod|independent independent|ccomp|revealed revealed|nsubjpass|production production|compound|END_ENTITY	An interleukin_4 -LRB- IL-4 -RRB- - independent pathway for CD4 + T cell IL-4 production is revealed in IL-4 receptor-deficient mice .
26831416	0	interleukin_4	77,90	IL13	98,102	interleukin 4	IL13	3565	3596	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
26831416	0	interleukin_4	77,90	IL4	92,95	interleukin 4	IL4	3565	3565	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	A preliminary study on the association of single nucleotide polymorphisms of interleukin_4 -LRB- IL4 -RRB- , IL13 , IL4 receptor alpha -LRB- IL4Ra -RRB- _ Toll-like_receptor_4 -LRB- TLR4 -RRB- genes with asthma in Indian adults .
8314773	0	interleukin_4	38,51	IL4	53,56	interleukin 4	IL4	3565	3565	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	A wide range of human cancers express interleukin_4 -LRB- IL4 -RRB- receptors that can be targeted with chimeric toxin composed of IL4 and Pseudomonas exotoxin .
3114369	0	interleukin_4	37,50	IL_4	52,56	interleukin 4	IL 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Interleukin 1-mediated activation of interleukin_4 -LRB- IL_4 -RRB- - producing T lymphocytes .
10207105	0	interleukin_4	45,58	Insulin-like_growth_factor_I	0,28	interleukin 4	Insulin-like growth factor I	3565	3479	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Insulin-like_growth_factor_I synergizes with interleukin_4 for hematopoietic cell proliferation independent of insulin receptor substrate expression .
10077630	0	interleukin_4	43,56	Intercellular_adhesion_molecule-1	0,33	interleukin 4	Intercellular adhesion molecule-1	16189(Tax:10090)	15894(Tax:10090)	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Intercellular_adhesion_molecule-1 inhibits interleukin_4 production by naive T cells .
11838858	0	interleukin_4	17,30	Interferon-gamma	0,16	interleukin 4	Interferon-gamma	3565	3458	Gene	Gene	ratios|amod|START_ENTITY END_ENTITY|dep|ratios	Interferon-gamma : interleukin_4 ratios and associated type 1 cytokine expression in juvenile_rheumatoid_arthritis synovial tissue .
8596138	0	interleukin_4	31,44	Interleukin_10	0,14	interleukin 4	Interleukin 10	3565	3586	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Interleukin_10 cooperates with interleukin_4 to suppress inflammatory cytokine production by freshly prepared adherent rheumatoid synovial cells .
1679715	0	interleukin_4	143,156	Interleukin_4	0,13	interleukin 4	Interleukin 4	16189(Tax:10090)	16189(Tax:10090)	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Interleukin_4 receptor targeted cytotoxicity : genetic construction and in vivo immunosuppressive activity of a diphtheria toxin-related murine interleukin_4 fusion protein .
1394231	0	interleukin_4	86,99	Interleukin_4_receptor	0,22	interleukin 4	Interleukin 4 receptor	3565	3566	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin_4_receptor expression and growth inhibition of gastric_carcinoma cells by interleukin_4 .
3262706	0	interleukin_4	47,60	Interleukin_5	0,13	interleukin 4	Interleukin 5	3565	3567	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Interleukin_5 and interleukin_2 cooperate with interleukin_4 to induce IgG1 secretion from anti-Ig-treated B cells .
7864891	0	interleukin_4	34,47	Interleukin_8	0,13	interleukin 4	Interleukin 8	3565	3576	Gene	Gene	IL-4|nummod|START_ENTITY inhibits|dobj|IL-4 inhibits|nsubj|END_ENTITY	Interleukin_8 -LRB- IL-8 -RRB- inhibits the interleukin_4 -LRB- IL-4 -RRB- - induced but not the spontaneous growth of human B cells via mechanisms that may involve protein kinase C. IL-8 inhibited the IL-4-induced but not the spontaneous growth of both a human B cell line , CBL , and in vivo activated B cells .
11739727	0	interleukin_4	29,42	Stat6	0,5	interleukin 4	Stat6	16189(Tax:10090)	20852(Tax:10090)	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|nsubj|END_ENTITY	Stat6 and IRS-2 cooperate in interleukin_4 -LRB- IL-4 -RRB- - induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis .
19801646	0	interleukin_4	79,92	TRAP	184,188	interleukin 4	TRAP	16189(Tax:10090)	11433(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulation|nmod|expression suppresses|nsubj|regulation suppresses|dobj|activator activator|nmod|ligand ligand|dep|expression expression|amod|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
19801646	0	interleukin_4	79,92	TRAP	59,63	interleukin 4	TRAP	16189(Tax:10090)	11433(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
9670042	0	interleukin_4	115,128	chemokine_receptor	163,181	interleukin 4	chemokine receptor	3565	7852	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	CD4 T cell cytokine differentiation : the B cell activation molecule , OX40_ligand , instructs CD4 T cells to express interleukin_4 and upregulates expression of the chemokine_receptor , Blr-1 .
2145107	0	interleukin_4	103,116	interferon-gamma	122,138	interleukin 4	interferon-gamma	3565	3458	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Determinants of the immune response in visceral_leishmaniasis : evidence for predominance of endogenous interleukin_4 over interferon-gamma production .
2530302	0	interleukin_4	12,25	interferon_gamma	55,71	interleukin 4	interferon gamma	3565	3458	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|production production|nmod|END_ENTITY	Recombinant interleukin_4 suppresses the production of interferon_gamma by human mononuclear cells .
2083227	0	interleukin_4	145,158	interleukin_2	113,126	interleukin 4	interleukin 2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Interleukin_7 stimulates growth of fetal thymic precursors of cytolytic cells : induction of effector function by interleukin_2 and inhibition by interleukin_4 .
2174560	0	interleukin_4	52,65	interleukin_2	27,40	interleukin 4	interleukin 2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	induction|dep|START_ENTITY induction|nmod|END_ENTITY	cAMP inhibits induction of interleukin_2 but not of interleukin_4 in T cells .
3126257	0	interleukin_4	23,36	interleukin_2	8,21	interleukin 4	interleukin 2	16189(Tax:10090)	16183(Tax:10090)	Gene	Gene	beta|amod|START_ENTITY beta|amod|END_ENTITY	Role of interleukin_2 , interleukin_4 , and alpha , beta , and gamma interferon in stimulating macrophage antibody-dependent tumoricidal activity .
8356077	0	interleukin_4	67,80	interleukin_2	30,43	interleukin 4	interleukin 2	3565	3558	Gene	Gene	function|nmod|START_ENTITY function|nsubj|regulation regulation|nmod|END_ENTITY	Molecular regulation of human interleukin_2 and T-cell function by interleukin_4 .
1828424	0	interleukin_4	106,119	interleukin_4_receptor	48,70	interleukin 4	interleukin 4 receptor	3565	3566	Gene	Gene	effects|nmod|START_ENTITY inhibits|dobj|effects inhibits|nsubj|domain domain|nmod|END_ENTITY	A recombinant extracellular domain of the human interleukin_4_receptor inhibits the biological effects of interleukin_4 on T and B lymphocytes .
8275499	0	interleukin_4	14,27	interleukin_6	60,73	interleukin 4	interleukin 6	16189(Tax:10090)	16193(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition by interleukin_4 of leukemia_inhibitory_factor - , interleukin_6 - , and dexamethasone-induced differentiation of mouse myeloid_leukemia cells : role of c-myc and junB proto-oncogenes .
8402641	0	interleukin_4	21,34	interleukin_6	52,65	interleukin 4	interleukin 6	3565	3569	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of interleukin_4 on production of interleukin_6 by adult_T-cell_leukemia cells .
2206128	0	interleukin_4	114,127	interleukin_8	24,37	interleukin 4	interleukin 8	3565	3576	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Disparate regulation of interleukin_8 gene expression from blood monocytes , endothelial cells , and fibroblasts by interleukin_4 .
9690907	0	interleukin_4	11,24	matrix_metalloproteinase_1	42,68	interleukin 4	matrix metalloproteinase 1	3565	4312	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for interleukin_4 in production of matrix_metalloproteinase_1 by human aortic smooth_muscle_cells .
19801646	0	interleukin_4	79,92	tartrate-resistant_acid_phosphatase	22,57	interleukin 4	tartrate-resistant acid phosphatase	16189(Tax:10090)	11433(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
9619370	0	interleukin_4_receptor	22,44	IL-4R	46,51	interleukin 4 receptor	IL-4R	3566	3566	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Function of the human interleukin_4_receptor -LRB- IL-4R -RRB- - derived acidic motif revealed by cytoplasmic domain chimeras of the IL-4R_alpha chain and the IL-2R_beta chain .
7538655	0	interleukin_4_receptor	31,53	JAK3	0,4	interleukin 4 receptor	JAK3	3566	3718	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	JAK3 associates with the human interleukin_4_receptor and is tyrosine phosphorylated following receptor triggering .
1340208	0	interleukin_5	14,27	CD4	35,38	interleukin 5	CD4	3567	920	Gene	Gene	START_ENTITY|nmod|subset subset|compound|END_ENTITY	Expression of interleukin_5 by the CD4 + CD45R0 + subset of human T cells .
3284812	0	interleukin_5	30,43	T_cell-replacing_factor	0,23	interleukin 5	T cell-replacing factor	16191(Tax:10090)	16191(Tax:10090)	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	T_cell-replacing_factor -LRB- TRF -RRB- / interleukin_5 -LRB- IL-5 -RRB- : molecular and functional properties .
9505142	0	interleukin_6	38,51	Bradykinin	0,10	interleukin 6	Bradykinin	3569	3827	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Bradykinin synergistically stimulates interleukin_6 production in human gingival fibroblasts challenged with interleukin 1 or tumour_necrosis factor alpha .
11167745	0	interleukin_6	113,126	C-reactive_protein	93,111	interleukin 6	C-reactive protein	3569	1401	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
16406714	0	interleukin_6	125,138	C-reactive_protein	20,38	interleukin 6	C-reactive protein	3569	1401	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Unresponsiveness Unresponsiveness|nmod|END_ENTITY	Unresponsiveness of C-reactive_protein in the non-infectious inflammation of systemic_lupus_erythematosus is associated with interleukin_6 .
20834028	0	interleukin_6	20,33	C-reactive_protein	0,18	interleukin 6	C-reactive protein	3569	1401	Gene	Gene	role|nsubj|START_ENTITY role|advmod|END_ENTITY	C-reactive_protein , interleukin_6 , and N-terminal pro-brain natriuretic peptide following cardioversion of atrial_fibrillation : is there a role of biomarkers in arrhythmia recurrence ?
24026232	0	interleukin_6	112,125	C-reactive_protein	127,145	interleukin 6	C-reactive protein	3569	1401	Gene	Gene	count|amod|START_ENTITY count|amod|END_ENTITY	Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein , interleukin_6 , C-reactive_protein , white blood cell count , erythrocyte sedimentation rate and body temperature .
12077104	0	interleukin_6	164,177	CD44	141,145	interleukin 6	CD44	3569	960	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	High frequency of autoantibodies in patients with primary_sclerosing_cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin_6 .
14979481	0	interleukin_6	54,67	CD45	33,37	interleukin 6	CD45	3569	5788	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The protein tyrosine phosphatase CD45 is required for interleukin_6 signaling in U266 myeloma cells .
22301607	0	interleukin_6	74,87	Guanine-nucleotide_exchange_factor_H1	0,37	interleukin 6	Guanine-nucleotide exchange factor H1	3569	9181	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Guanine-nucleotide_exchange_factor_H1 mediates lipopolysaccharide-induced interleukin_6 and tumor_necrosis_factor_a expression in endothelial cells via activation of nuclear factor kB .
10214897	0	interleukin_6	25,38	IL-6	40,44	interleukin 6	IL-6	3569	3569	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Quantitative analysis of interleukin_6 -LRB- IL-6 -RRB- in patients with IgA_nephropathy after tonsillectomy .
10385616	0	interleukin_6	60,73	IL-6	75,79	interleukin 6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Central injection of nicotine increases hepatic and splenic interleukin_6 -LRB- IL-6 -RRB- mRNA expression and plasma IL-6 levels in mice : involvement of the peripheral sympathetic nervous system .
1311016	0	interleukin_6	8,21	IL-6	23,27	interleukin 6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of interleukin_6 -LRB- IL-6 -RRB- in protection from lethal irradiation and in endocrine responses to IL-1 and tumor_necrosis_factor .
17317452	0	interleukin_6	27,40	IL-6	42,46	interleukin 6	IL-6	3569	3569	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Associations of the plasma interleukin_6 -LRB- IL-6 -RRB- levels with disability and mortality in the elderly in the Treviso Longeva -LRB- Trelong -RRB- study .
22509361	0	interleukin_6	44,57	IL-6	59,63	interleukin 6	IL-6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of -174 G > C and -572 G > C in the interleukin_6 -LRB- IL-6 -RRB- gene and coronary_heart_disease risk : a meta-analysis of 27 research studies .
24886605	0	interleukin_6	26,39	IL-6	41,45	interleukin 6	IL-6	3569	3569	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Genetic modulation of the interleukin_6 -LRB- IL-6 -RRB- system in patients with advanced gastric_cancer : a background for an alternative target therapy .
3263278	0	interleukin_6	10,23	IL-6	25,29	interleukin 6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of interleukin_6 -LRB- IL-6 -RRB- on the differentiation and proliferation of murine and human hemopoietic progenitors .
7744784	0	interleukin_6	13,26	IL-6	28,32	interleukin 6	IL-6	16193(Tax:10090)	16193(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of interleukin_6 -LRB- IL-6 -RRB- by hypoxia in vascular cells .
8627341	0	interleukin_6	58,71	IL-6	73,77	interleukin 6	IL-6	3569	3569	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- and interleukin_6 -LRB- IL-6 -RRB- mRNA in adult human astrocytes : comparison with adult microglia and fetal astrocytes .
8666898	0	interleukin_6	28,41	IL-6	136,140	interleukin 6	IL-6	3569	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY function|nmod|receptor function|dep|sensitization sensitization|nmod|transgenic_mice transgenic_mice|nmod|END_ENTITY	The function of the soluble interleukin_6 -LRB- IL-6 -RRB- receptor in vivo : sensitization of human soluble IL-6_receptor transgenic_mice towards IL-6 and prolongation of the plasma half-life of IL-6 .
8666898	0	interleukin_6	28,41	IL-6	185,189	interleukin 6	IL-6	3569	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY function|nmod|receptor function|dep|sensitization sensitization|nmod|half-life half-life|nmod|END_ENTITY	The function of the soluble interleukin_6 -LRB- IL-6 -RRB- receptor in vivo : sensitization of human soluble IL-6_receptor transgenic_mice towards IL-6 and prolongation of the plasma half-life of IL-6 .
8666898	0	interleukin_6	28,41	IL-6	43,47	interleukin 6	IL-6	3569	16193(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The function of the soluble interleukin_6 -LRB- IL-6 -RRB- receptor in vivo : sensitization of human soluble IL-6_receptor transgenic_mice towards IL-6 and prolongation of the plasma half-life of IL-6 .
9375862	0	interleukin_6	8,21	IL-6	23,27	interleukin 6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Soluble interleukin_6 -LRB- IL-6 -RRB- receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies .
9722935	0	interleukin_6	8,21	IL-6	23,27	interleukin 6	IL-6	3569	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Soluble interleukin_6 -LRB- IL-6 -RRB- receptor influences the expression of the protooncogene junB and the production of fibrinogen in the HepG2 human hepatoma cell line and primary rat hepatocytes .
23564454	0	interleukin_6	8,21	IL-6_receptor	60,73	interleukin 6	IL-6 receptor	3569	3570	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Minimal interleukin_6 -LRB- IL-6 -RRB- receptor stalk composition for IL-6_receptor shedding and IL-6 classic signaling .
23662429	0	interleukin_6	80,93	IL6	100,103	interleukin 6	IL6	3569	3569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Allele frequency distributions of -174 G/C polymorphism in regulatory region of interleukin_6 gene -LRB- IL6 -RRB- in Russian and worldwide populations -RSB- .
7526705	0	interleukin_6	31,44	Interferon-gamma	0,16	interleukin 6	Interferon-gamma	3569	3458	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Interferon-gamma regulation of interleukin_6 in monocytic cells .
2472425	0	interleukin_6	18,31	Interferon_beta_2	0,17	interleukin 6	Interferon beta 2	3569	3569	Gene	Gene	modulates|nsubj|START_ENTITY END_ENTITY|parataxis|modulates	Interferon_beta_2 / interleukin_6 modulates synthesis of alpha_1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells .
8744678	0	interleukin_6	24,37	Interleukin_10	0,14	interleukin 6	Interleukin 10	3569	3586	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin_10 inhibits interleukin_6 production and acute phase response in rheumatoid_arthritis .
7768376	0	interleukin_6	45,58	Interleukin_1_beta	0,18	interleukin 6	Interleukin 1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_1_beta induces the expression of interleukin_6 in rat intestinal smooth muscle cells .
1899386	0	interleukin_6	22,35	Interleukin_4	0,13	interleukin 6	Interleukin 4	3569	3565	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin_4 induces interleukin_6 production by endothelial cells : synergy with interferon-gamma .
2677211	0	interleukin_6	46,59	Interleukin_4	0,13	interleukin 6	Interleukin 4	3569	3565	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin_4 induces selective production of interleukin_6 from normal human B lymphocytes .
12093869	0	interleukin_6	34,47	NFATc2	13,19	interleukin 6	NFATc2	3569	4773	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of NFATc2 expression by interleukin_6 promotes T helper type 2 differentiation .
12782602	0	interleukin_6	177,190	STAT3	72,77	interleukin 6	STAT3	3569	6774	Gene	Gene	system|amod|START_ENTITY stimulation|nmod|system mediated|nmod|stimulation mediated|nsubjpass|activation activation|nmod|END_ENTITY	Epidermal_growth_factor_receptor-independent constitutive activation of STAT3 in head_and_neck_squamous_cell_carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin_6 / gp130 cytokine system .
9196070	0	interleukin_6	22,35	Somatostatin	0,12	interleukin 6	Somatostatin	24498(Tax:10116)	24797(Tax:10116)	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Somatostatin inhibits interleukin_6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase .
10447634	0	interleukin_6	61,74	Stat3	37,42	interleukin 6	Stat3	24498(Tax:10116)	25125(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Rapid and simultaneous activation of Stat3 and production of interleukin_6 in resuscitated hemorrhagic_shock .
21633411	0	interleukin_6	6,19	TLR4	97,101	interleukin 6	TLR4	16193(Tax:10090)	21898(Tax:10090)	Gene	Gene	production|amod|START_ENTITY regulated|nsubjpass|production regulated|nmod|END_ENTITY	Early interleukin_6 production by leukocytes during ischemic_acute_kidney_injury is regulated by TLR4 .
17725274	0	interleukin_6	121,134	TNF-alpha	109,118	interleukin 6	TNF-alpha	3569	7124	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|tumor_necrosis_factor tumor_necrosis_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
2104224	0	interleukin_6	58,71	Transforming_growth_factor_beta	0,31	interleukin 6	Transforming growth factor beta	3569	7040	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Transforming_growth_factor_beta induces the production of interleukin_6 by human peripheral blood mononuclear cells .
17725274	0	interleukin_6	121,134	VEGF	79,83	interleukin 6	VEGF	3569	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
11267862	0	interleukin_6	55,68	beta-catenin	28,40	interleukin 6	beta-catenin	3569	1499	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Downregulation of wild-type beta-catenin expression by interleukin_6 in human hepatocarcinoma HepG2 cells : a possible role in the growth-regulatory effects of the cytokine ?
9325015	0	interleukin_6	14,27	cardiotrophin_1	42,57	interleukin 6	cardiotrophin 1	3569	1489	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of interleukin_6 expression by cardiotrophin_1 .
12782602	0	interleukin_6	177,190	gp130	191,196	interleukin 6	gp130	3569	3572	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Epidermal_growth_factor_receptor-independent constitutive activation of STAT3 in head_and_neck_squamous_cell_carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin_6 / gp130 cytokine system .
9154468	0	interleukin_6	48,61	granulocyte-colony_stimulating_factor	10,47	interleukin 6	granulocyte-colony stimulating factor	3569	1440	Gene	Gene	molecules|amod|START_ENTITY molecules|amod|END_ENTITY	Harlequin granulocyte-colony_stimulating_factor interleukin_6 molecules with bifunctional and antagonistic activities .
8278382	0	interleukin_6	96,109	granulocyte_inhibitory_protein	2,32	interleukin 6	granulocyte inhibitory protein	3569	2695	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	A granulocyte_inhibitory_protein overexpressed in chronic renal_disease regulates expression of interleukin_6 and interleukin_8 .
3349651	0	interleukin_6	58,71	hybridoma_growth_factor	33,56	interleukin 6	hybridoma growth factor	3569	3569	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Elevated levels of the 26K human hybridoma_growth_factor -LRB- interleukin_6 -RRB- in cerebrospinal fluid of patients with acute_infection_of_the_central_nervous_system .
11052818	0	interleukin_6	12,25	interferon-gamma	29,45	interleukin 6	interferon-gamma	16193(Tax:10090)	15978(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|production production|amod|END_ENTITY	The role of interleukin_6 in interferon-gamma production in thermally injured mice .
1899386	0	interleukin_6	22,35	interferon-gamma	82,98	interleukin 6	interferon-gamma	3569	3458	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|parataxis|synergy synergy|nmod|END_ENTITY	Interleukin_4 induces interleukin_6 production by endothelial cells : synergy with interferon-gamma .
22422499	0	interleukin_6	123,136	interferon-y	60,72	interleukin 6	interferon-y	3569	3458	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Systemic_sclerosis fibroblasts show specific alterations of interferon-y and tumor_necrosis_factor-a-induced modulation of interleukin_6 and chemokine ligand 2 .
12879762	0	interleukin_6	43,56	interleukin_1	28,41	interleukin 6	interleukin 1	3569	3552	Gene	Gene	plasma|nummod|START_ENTITY plasma|nummod|END_ENTITY	-LSB- Predictive value of plasma interleukin_1 , interleukin_6 , interleukin_8 and C-reactive_protein -LRB- CRP -RRB- in patients with myocardial_infarction -RSB- .
1959943	0	interleukin_6	24,37	interleukin_1	100,113	interleukin 6	interleukin 1	16193(Tax:10090)	111343(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|dep|stimulation stimulation|nmod|induction induction|amod|END_ENTITY	Defective production of interleukin_6 by macrophages from C3H/HeJ mice : differential stimulation of interleukin_1 and interleukin_6 induction .
2407240	0	interleukin_6	25,38	interleukin_1	63,76	interleukin 6	interleukin 1	3569	3552	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Independent induction of interleukin_6 and prostaglandin_E2 by interleukin_1 in human articular chondrocytes .
7962445	0	interleukin_6	49,62	interleukin_1_and_placental_protein_14	77,115	interleukin 6	interleukin 1 and placental protein 14	3569	3552;5047	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Stimulation of human endometrial epithelial cell interleukin_6 production by interleukin_1_and_placental_protein_14 .
1873483	0	interleukin_6	10,23	interleukin_1_beta	72,90	interleukin 6	interleukin 1 beta	24498(Tax:10116)	24494(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|dep|effect effect|nmod|hormone hormone|amod|END_ENTITY	Augmented interleukin_6 production by rat thyrocytes -LRB- FRTL5 -RRB- : effect of interleukin_1_beta and thyroid-stimulating hormone .
10049521	0	interleukin_6	15,28	interleukin_1alpha	34,52	interleukin 6	interleukin 1alpha	3569	3552	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of interleukin_6 with interleukin_1alpha in human mammary tumours , but not with oestrogen receptor expression .
9578118	0	interleukin_6	12,25	interleukin_2	42,55	interleukin 6	interleukin 2	3569	3558	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Increase of interleukin_6 and decrease of interleukin_2 production during the ageing process are influenced by the health status .
9883316	0	interleukin_6	34,47	interleukin_2	10,23	interleukin 6	interleukin 2	3569	3558	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Exogenous interleukin_2 regulates interleukin_6 and nitric_oxide but not interferon gamma and tumor necrosis factor alpha production in bronchoalveolar leukocytes from patients with small cell lung_cancer .
8275499	0	interleukin_6	60,73	interleukin_4	14,27	interleukin 6	interleukin 4	16193(Tax:10090)	16189(Tax:10090)	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by interleukin_4 of leukemia_inhibitory_factor - , interleukin_6 - , and dexamethasone-induced differentiation of mouse myeloid_leukemia cells : role of c-myc and junB proto-oncogenes .
8402641	0	interleukin_6	52,65	interleukin_4	21,34	interleukin 6	interleukin 4	3569	3565	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of interleukin_4 on production of interleukin_6 by adult_T-cell_leukemia cells .
11167745	0	interleukin_6	113,126	interleukin_8	128,141	interleukin 6	interleukin 8	3569	3576	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
12879762	0	interleukin_6	43,56	interleukin_8	58,71	interleukin 6	interleukin 8	3569	3576	Gene	Gene	plasma|nummod|START_ENTITY plasma|nummod|END_ENTITY	-LSB- Predictive value of plasma interleukin_1 , interleukin_6 , interleukin_8 and C-reactive_protein -LRB- CRP -RRB- in patients with myocardial_infarction -RSB- .
16308433	0	interleukin_6	32,45	interleukin_8	47,60	interleukin 6	interleukin 8	3569	3576	Gene	Gene	urine|nummod|START_ENTITY urine|nummod|END_ENTITY	-LSB- Correlational studies of urine interleukin_6 , interleukin_8 and nitric_oxide in the patients with pyelonephritis and hydronephrosis -RSB- .
9617576	0	interleukin_6	36,49	leukaemia_inhibitory_factor	7,34	interleukin 6	leukaemia inhibitory factor	3569	3976	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Plasma leukaemia_inhibitory_factor , interleukin_6 and soluble interleukin_6 receptor levels during cardiopulmonary bypass with extracorporeal circulation .
24026232	0	interleukin_6	112,125	lipopolysaccharide-binding-protein	76,110	interleukin 6	lipopolysaccharide-binding-protein	3569	3929	Gene	Gene	count|amod|START_ENTITY count|amod|END_ENTITY	Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein , interleukin_6 , C-reactive_protein , white blood cell count , erythrocyte sedimentation rate and body temperature .
17363400	0	interleukin_6	126,139	matrix_metalloproteinase_1	98,124	interleukin 6	matrix metalloproteinase 1	3569	4312	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Genetic susceptibility to total hip arthroplasty failure : a preliminary study on the influence of matrix_metalloproteinase_1 , interleukin_6 polymorphisms and vitamin_D_receptor .
7512571	0	interleukin_6	55,68	oncostatin_M	69,81	interleukin 6	oncostatin M	3569	5008	Gene	Gene	family|amod|START_ENTITY family|compound|END_ENTITY	Ciliary_neurotrophic_factor / leukemia_inhibitory_factor / interleukin_6 / oncostatin_M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors .
12384515	0	interleukin_6	79,92	p300	0,4	interleukin 6	p300	3569	2033	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	p300 mediates androgen-independent transactivation of the androgen_receptor by interleukin_6 .
10655271	0	interleukin_6	83,96	phosphoenolpyruvate_carboxykinase	100,133	interleukin 6	phosphoenolpyruvate carboxykinase	24498(Tax:10116)	362282(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Phosphatidylinositol 3-kinase and protein kinase C contribute to the inhibition by interleukin_6 of phosphoenolpyruvate_carboxykinase gene expression in cultured rat hepatocytes .
7749575	0	interleukin_6	40,53	transforming_growth_factor_beta	68,99	interleukin 6	transforming growth factor beta	3569	7040	Gene	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of monocyte and keratinocyte interleukin_6 production by transforming_growth_factor_beta .
17725274	0	interleukin_6	121,134	tumor_necrosis_factor	86,107	interleukin 6	tumor necrosis factor	3569	7124	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
1991487	0	interleukin_6	111,124	tumor_necrosis_factor	82,103	interleukin 6	tumor necrosis factor	3569	7124	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|dobj|stimulation	L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor_necrosis_factor and/or interleukin_6 stimulation .
2364381	0	interleukin_6	91,104	tumor_necrosis_factor	49,70	interleukin 6	tumor necrosis factor	24498(Tax:10116)	103694380	Gene	Gene	role|nmod|START_ENTITY Search|dep|role Search|nmod|mediators mediators|nmod|effects effects|nmod|END_ENTITY	Search for mediators of the lipogenic effects of tumor_necrosis_factor : potential role for interleukin_6 .
12771987	0	interleukin_6	36,49	vascular_endothelial_growth_factor	84,118	interleukin 6	vascular endothelial growth factor	3569	7422	Gene	Gene	levels|amod|START_ENTITY levels|nmod|levels value|nmod|levels value|nmod|END_ENTITY	Prognostic value of serum levels of interleukin_6 and of serum and plasma levels of vascular_endothelial_growth_factor in hormone-refractory metastatic breast_cancer patients .
15093584	0	interleukin_6	138,151	vascular_endothelial_growth_factor	22,56	interleukin 6	vascular endothelial growth factor	3569	7422	Gene	Gene	treatment|nmod|START_ENTITY generated|nmod|treatment cells|acl|generated established|nmod|cells established|nsubjpass|loop loop|nmod|END_ENTITY	An autocrine loop for vascular_endothelial_growth_factor is established in prostate_cancer cells generated after prolonged treatment with interleukin_6 .
20887801	0	interleukin_6_and_8	111,130	toll-like_receptor_4	59,79	interleukin 6 and 8	toll-like receptor 4	3569;3576	7099	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Opisthorchis viverrini excretory/secretory products induce toll-like_receptor_4 upregulation and production of interleukin_6_and_8 in cholangiocyte .
17671508	0	interleukin_6_receptor	24,46	IL-6r	48,53	interleukin 6 receptor	IL-6r	3570	3570	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common variant of the interleukin_6_receptor -LRB- IL-6r -RRB- gene increases IL-6r and IL-6 levels , without other inflammatory effects .
12655571	0	interleukin_6_receptor	36,58	IL6R	65,69	interleukin 6 receptor	IL6R	3570	3570	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of novel SNPs in the interleukin_6_receptor gene -LRB- IL6R -RRB- .
1429553	0	interleukin_6_receptors	19,42	leukemia_inhibitory_factor	85,111	interleukin 6 receptors	leukemia inhibitory factor	16194(Tax:10090)	16878(Tax:10090)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of interleukin_6_receptors of mouse myelomonocytic_leukemic cells by leukemia_inhibitory_factor .
11396992	0	interleukin_7	14,27	IL-7	29,33	interleukin 7	IL-7	3574	3574	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of interleukin_7 -LRB- IL-7 -RRB- mRNA and protein in the normal adult_human_liver : implications for extrathymic T cell development .
1678354	0	interleukin_7	15,28	IL-7	30,34	interleukin 7	IL-7	3574	3574	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of interleukin_7 -LRB- IL-7 -RRB- on human bone marrow in vitro .
8589262	0	interleukin_7	15,28	IL-7	30,34	interleukin 7	IL-7	3574	3574	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of interleukin_7 -LRB- IL-7 -RRB- with glycosaminoglycans and its biological relevance .
11474182	0	interleukin_7	43,56	IL7	63,66	interleukin 7	IL7	3574	3574	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and assignment of the interleukin_7 gene -LRB- IL7 -RRB- to porcine chromosome 4q11 -- > q13 by FISH and by analysis of radiation hybrid panels .
2786840	0	interleukin_7	19,32	IL7	34,37	interleukin 7	IL7	3574	3574	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for human interleukin_7 -LRB- IL7 -RRB- is at 8q12-13 .
11167745	0	interleukin_8	128,141	C-reactive_protein	93,111	interleukin 8	C-reactive protein	3576	1401	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
15231900	0	interleukin_8	15,28	C-reactive_protein	49,67	interleukin 8	C-reactive protein	3576	1401	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Measurement of interleukin_8 in combination with C-reactive_protein reduced unnecessary antibiotic therapy in newborn infants : a multicenter , randomized , controlled trial .
12496258	0	interleukin_8	22,35	CXCR2	112,117	interleukin 8	CXCR2	3576	3579	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|END_ENTITY	Angiogenic effects of interleukin_8 -LRB- CXCL8 -RRB- in human intestinal microvascular endothelial cells are mediated by CXCR2 .
8666380	0	interleukin_8	108,121	GPR10	60,65	interleukin 8	GPR10	3576	2834	Gene	Gene	related|nmod|START_ENTITY related|nsubj|END_ENTITY	Cloning and chromosomal mapping of three novel genes , GPR9 , GPR10 , and GPR14 , encoding receptors related to interleukin_8 , neuropeptide Y , and somatostatin receptors .
12169272	0	interleukin_8	34,47	Lymphotoxin_beta_receptor	0,25	interleukin 8	Lymphotoxin beta receptor	3576	4055	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Lymphotoxin_beta_receptor induces interleukin_8 gene expression via NF-kappaB and AP-1 activation .
1873480	0	interleukin_8	32,45	Neutrophil-activating_peptide_1	0,31	interleukin 8	Neutrophil-activating peptide 1	3576	3576	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Neutrophil-activating_peptide_1 / interleukin_8 mRNA expression and protein secretion by human monocytes : effect of cyclosporin_A .
11280799	0	interleukin_8	44,57	Parathyroid_hormone-related_protein	0,35	interleukin 8	Parathyroid hormone-related protein	3576	5744	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Parathyroid_hormone-related_protein induces interleukin_8 production by prostate_cancer cells via a novel intracrine mechanism not mediated by its classical nuclear localization sequence .
24587311	0	interleukin_8	21,34	Urotensin_II	0,12	interleukin 8	Urotensin II	3576	10911	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Urotensin_II induces interleukin_8 expression in human umbilical vein endothelial cells .
16118510	0	interleukin_8	50,63	alpha-melanocyte-stimulating_hormone	10,46	interleukin 8	alpha-melanocyte-stimulating hormone	3576	5443	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of alpha-melanocyte-stimulating_hormone on interleukin_8 and monocyte_chemotactic_protein_1 expression in a human retinal pigment epithelial cell line .
23526216	0	interleukin_8	116,129	cAMP-response_element_binding_protein_1	50,89	interleukin 8	cAMP-response element binding protein 1	3576	1385	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Role of hypoxia-inducible factor 1 , a subunit and cAMP-response_element_binding_protein_1 in synergistic release of interleukin_8 by prostaglandin_E2 and nickel in lung fibroblasts .
1755377	0	interleukin_8	20,33	interleukin-8	129,142	interleukin 8	interleukin-8	3576	3576	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of human interleukin_8 gene expression and binding of several other members of the intercrine family to receptors for interleukin-8 .
12879762	0	interleukin_8	58,71	interleukin_1	28,41	interleukin 8	interleukin 1	3576	3552	Gene	Gene	plasma|nummod|START_ENTITY plasma|nummod|END_ENTITY	-LSB- Predictive value of plasma interleukin_1 , interleukin_6 , interleukin_8 and C-reactive_protein -LRB- CRP -RRB- in patients with myocardial_infarction -RSB- .
2206128	0	interleukin_8	24,37	interleukin_4	114,127	interleukin 8	interleukin 4	3576	3565	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Disparate regulation of interleukin_8 gene expression from blood monocytes , endothelial cells , and fibroblasts by interleukin_4 .
11167745	0	interleukin_8	128,141	interleukin_6	113,126	interleukin 8	interleukin 6	3576	3569	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Procalcitonin in paediatric cancer patients : its diagnostic relevance is superior to that of C-reactive_protein , interleukin_6 , interleukin_8 , soluble interleukin 2 receptor and soluble tumour necrosis factor receptor II .
12879762	0	interleukin_8	58,71	interleukin_6	43,56	interleukin 8	interleukin 6	3576	3569	Gene	Gene	plasma|nummod|START_ENTITY plasma|nummod|END_ENTITY	-LSB- Predictive value of plasma interleukin_1 , interleukin_6 , interleukin_8 and C-reactive_protein -LRB- CRP -RRB- in patients with myocardial_infarction -RSB- .
16308433	0	interleukin_8	47,60	interleukin_6	32,45	interleukin 8	interleukin 6	3576	3569	Gene	Gene	urine|nummod|START_ENTITY urine|nummod|END_ENTITY	-LSB- Correlational studies of urine interleukin_6 , interleukin_8 and nitric_oxide in the patients with pyelonephritis and hydronephrosis -RSB- .
8901116	0	interleukin_8	59,72	lactoferrin	11,22	interleukin 8	lactoferrin	3576	280846(Tax:9913)	Gene	Gene	release|nmod|START_ENTITY Effects|nmod|release Effects|nmod|END_ENTITY	Effects of lactoferrin and lactoferricin on the release of interleukin_8 from human polymorphonuclear leukocytes .
1438244	0	interleukin_8	83,96	neutrophil-activating_peptide_2	48,79	interleukin 8	neutrophil-activating peptide 2	3576	5473	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	High - and low-affinity binding of GRO_alpha and neutrophil-activating_peptide_2 to interleukin_8 receptors on human neutrophils .
22392142	0	interleukin_8	73,86	p38	96,99	interleukin 8	p38	3576	1432	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	NADPH oxidase-derived superoxide destabilizes lipopolysaccharide-induced interleukin_8 mRNA via p38 , extracellular signal-regulated kinase mitogen-activated protein kinase , and the destabilizing factor tristetraprolin .
21046243	0	interleukin_8	141,154	toll-like_receptor_4	88,108	interleukin 8	toll-like receptor 4	3576	7099	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Small_intestinal_bacterial_overgrowth in nonalcoholic_steatohepatitis : association with toll-like_receptor_4 expression and plasma levels of interleukin_8 .
1433974	0	interleukin_9	65,78	IL-9	80,84	interleukin 9	IL-9	16198(Tax:10090)	16198(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Function , molecular structure and gene expression regulation of interleukin_9 -LRB- IL-9 -RRB- -RSB- .
8974006	0	interleukin_enhancer_binding_factor_2	8,45	ILF2	52,56	interleukin enhancer binding factor 2	ILF2	3608	3608	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping interleukin_enhancer_binding_factor_2 gene -LRB- ILF2 -RRB- to human chromosome 1 -LRB- 1q11-qter and 1p11-p12 -RRB- by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates .
11167023	0	interleukin_enhancer_binding_factor_3	34,71	ILF3	73,77	interleukin enhancer binding factor 3	ILF3	3609	3609	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative splicing in the human interleukin_enhancer_binding_factor_3 -LRB- ILF3 -RRB- gene .
9620363	0	interleukin_enhancer_binding_factor_3	8,45	ILF3	52,56	interleukin enhancer binding factor 3	ILF3	3609	3609	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping interleukin_enhancer_binding_factor_3 gene -LRB- ILF3 -RRB- to human chromosome 19 -LRB- 19q11-qter and 19p11-p13 .1 -RRB- by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates .
16032371	0	interleukins_2_and_12	11,32	granzyme_B	50,60	interleukins 2 and 12	granzyme B	3558	3002	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of interleukins_2_and_12 on the levels of granzyme_B and perforin and their mRNAs in tributyltin-exposed human natural killer cells .
2334896	0	interleukins_2_and_4	14,34	tumor_necrosis_factor	38,59	interleukins 2 and 4	tumor necrosis factor	16183;16189	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|compound|END_ENTITY	Influences of interleukins_2_and_4 on tumor_necrosis_factor production by murine mononuclear phagocytes .
23632023	0	interleukins_6_and_8	69,89	Matrix_metalloproteinase_8	0,26	interleukins 6 and 8	Matrix metalloproteinase 8	3569;3576	4317	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Matrix_metalloproteinase_8 -LRB- collagenase_2 -RRB- induces the expression of interleukins_6_and_8 in breast_cancer cells .
25080784	0	interleukins_8_and_10	156,177	glutathione-S-transferase	129,154	interleukins 8 and 10	glutathione-S-transferase	3576;3586	373156	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The association of risk of development of cardiomyopathies with polymorphic variants of genes of angiotensin converting enzyme , glutathione-S-transferase , interleukins_8_and_10 -RSB- .
19223297	0	intermediate_filament	16,37	vimentin	83,91	intermediate filament	vimentin	24387(Tax:10116)	81818(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY appraisal|nmod|expression appraisal|dep|expressed expressed|nsubjpass|END_ENTITY	An appraisal of intermediate_filament expression in adult and developing pancreas : vimentin is expressed in alpha cells of rat and mouse embryos .
21426942	0	intermediate_filament	96,117	vimentin	87,95	intermediate filament	vimentin	24387(Tax:10116)	81818(Tax:10116)	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	The nanomechanical properties of rat fibroblasts are modulated by interfering with the vimentin intermediate_filament system .
2661562	0	intermediate_filament	34,55	vimentin	14,22	intermediate filament	vimentin	24387(Tax:10116)	81818(Tax:10116)	Gene	Gene	distribution|amod|START_ENTITY containing|dobj|distribution Modulation|acl|containing Modulation|nmod|END_ENTITY	Modulation of vimentin containing intermediate_filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase .
16571784	0	intermediate_filament_protein	31,60	nestin	61,67	intermediate filament protein	nestin	18008(Tax:10090)	18008(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Differential expression of the intermediate_filament_protein nestin during renal development and its localization in adult podocytes .
18418734	0	intermedin	17,27	Adrenomedullin-2	0,16	intermedin	Adrenomedullin-2	399475(Tax:10116)	399475(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Adrenomedullin-2 / intermedin induces cAMP accumulation in dissociated rat spinal cord cells : evidence for the existence of a distinct class of sites of action .
20596793	0	intermedin	17,27	Adrenomedullin_2	0,16	intermedin	Adrenomedullin 2	79924	79924	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Adrenomedullin_2 / intermedin in the hypothalamo-pituitary-adrenal axis .
21816853	0	intermedin	17,27	Adrenomedullin_2	0,16	intermedin	Adrenomedullin 2	79924	79924	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	Adrenomedullin_2 / intermedin regulates HLA-G in human trophoblasts .
21816853	0	intermedin	17,27	HLA-G	38,43	intermedin	HLA-G	79924	3135	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Adrenomedullin_2 / intermedin regulates HLA-G in human trophoblasts .
23745696	0	intermedin	22,32	adrenomedullin	98,112	intermedin	adrenomedullin	79924	133	Gene	Gene	effects|nmod|START_ENTITY effects|dep|comparison comparison|nmod|END_ENTITY	Protective effects of intermedin on cardiovascular , pulmonary_and_renal_diseases : comparison with adrenomedullin and CGRP .
26767798	0	intermedin	17,27	adrenomedullin-2	29,45	intermedin	adrenomedullin-2	79924	79924	Gene	Gene	levels|nmod|START_ENTITY levels|dep|END_ENTITY	Plasma levels of intermedin -LRB- adrenomedullin-2 -RRB- in healthy human volunteers and patients with heart_failure .
19535789	0	intermedin	38,48	adrenomedullin_2	14,30	intermedin	adrenomedullin 2	79924	79924	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of adrenomedullin_2 -LRB- ADM2 -RRB- / intermedin -LRB- IMD -RRB- in human placenta : role in trophoblast invasion and migration .
21180135	0	intermedin	29,39	adrenomedullin_2	12,28	intermedin	adrenomedullin 2	399475(Tax:10116)	399475(Tax:10116)	Gene	Gene	Changes|dep|START_ENTITY Changes|nmod|END_ENTITY	-LSB- Changes of adrenomedullin_2 / intermedin in the lung of rats with chronic hypoxic pulmonary hypertension -RSB- .
25102228	0	intermedin	30,40	adrenomedullin_2	13,29	intermedin	adrenomedullin 2	399475(Tax:10116)	399475(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Induction of adrenomedullin_2 / intermedin expression by thyroid stimulating hormone in thyroid .
19331820	0	interphase_nucleus_and_mitotic_apparatus	54,94	INMAP	39,44	interphase nucleus and mitotic apparatus	INMAP	55703	55703	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of INMAP , a novel interphase_nucleus_and_mitotic_apparatus protein that is involved in spindle formation and cell cycle progression .
8328337	0	interphotoreceptor-retinoid-binding-protein	11,54	IRBP	56,60	interphotoreceptor-retinoid-binding-protein	IRBP	100723349	100723349	Gene	Gene	Change|nmod|START_ENTITY Change|appos|END_ENTITY	-LSB- Change in interphotoreceptor-retinoid-binding-protein -LRB- IRBP -RRB- after retinal_photocoagulation and cryopexy -RSB- .
9691169	0	interphotoreceptor_matrix_proteoglycan-1	57,97	IMPG1	99,104	interphotoreceptor matrix proteoglycan-1	IMPG1	3617	3617	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and chromosomal localization of the interphotoreceptor_matrix_proteoglycan-1 -LRB- IMPG1 -RRB- gene : a candidate for 6q-linked_retinopathies .
9719369	0	interphotoreceptor_matrix_proteoglycan-1	18,58	IMPG1	60,65	interphotoreceptor matrix proteoglycan-1	IMPG1	3617	3617	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assessment of the interphotoreceptor_matrix_proteoglycan-1 -LRB- IMPG1 -RRB- gene localised to 6q13-q15 in autosomal_dominant_Stargardt-like_disease -LRB- ADSTGD -RRB- , progressive bifocal chorioretinal_atrophy -LRB- PBCRA -RRB- , and North Carolina_macular_dystrophy -LRB- MCDR1 -RRB- .
11134581	0	interphotoreceptor_retinoid-binding_protein	14,57	IRBP	59,63	interphotoreceptor retinoid-binding protein	IRBP	5949	5949	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- gene expression by cAMP in differentiated retinoblastoma cells .
11278819	0	interphotoreceptor_retinoid-binding_protein	83,126	IRBP	133,137	interphotoreceptor retinoid-binding protein	IRBP	5949	5949	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The zinc finger transcription factor , MOK2 , negatively modulates expression of the interphotoreceptor_retinoid-binding_protein gene , IRBP .
11821982	0	interphotoreceptor_retinoid-binding_protein	84,127	IRBP	129,133	interphotoreceptor retinoid-binding protein	IRBP	281443(Tax:9913)	281443(Tax:9913)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Structural characterization and comparison of promoter activity of mouse and bovine interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- gene 5 ' flanking regions in WERI , Y79 , chick retina cells , and transgenic_mice .
1426058	0	interphotoreceptor_retinoid-binding_protein	45,88	IRBP	90,94	interphotoreceptor retinoid-binding protein	IRBP	5949	5949	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Photoreceptor-specific activity of the human interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- promoter in transgenic_mice .
2592435	0	interphotoreceptor_retinoid-binding_protein	27,70	IRBP	72,76	interphotoreceptor retinoid-binding protein	IRBP	19661(Tax:10090)	19661(Tax:10090)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis and secretion of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- by isolated normal and rd mouse retinal photoreceptor neurons in culture .
2697513	0	interphotoreceptor_retinoid-binding_protein	29,72	IRBP	74,78	interphotoreceptor retinoid-binding protein	IRBP	5949	5949	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Differential distribution of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- around retinal rod and cone photoreceptors .
9841935	0	interphotoreceptor_retinoid-binding_protein	28,71	IRBP	73,77	interphotoreceptor retinoid-binding protein	IRBP	30735(Tax:7955)	30735(Tax:7955)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Novel expression pattern of interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- in the adult and developing zebrafish retina and RPE .
1987260	0	interphotoreceptor_retinoid_binding_protein	13,56	IRBP	58,62	interphotoreceptor retinoid binding protein	IRBP	5949	5949	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Detection of interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- mRNA in human and cone-dominant squirrel retinas by in situ hybridization .
8660440	0	interphotoreceptor_retinoid_binding_protein	28,71	IRBP	73,77	interphotoreceptor retinoid binding protein	IRBP	5949	5949	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mammalian evolution and the interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- gene : convincing evidence for several superordinal clades .
6686234	0	interphotoreceptor_retinol-binding_protein	26,68	IRBP	70,74	interphotoreceptor retinol-binding protein	IRBP	5949	5949	Gene	Gene	presence|nmod|START_ENTITY presence|appos|END_ENTITY	The presence of a soluble interphotoreceptor_retinol-binding_protein -LRB- IRBP -RRB- in the retinal interphotoreceptor_space .
10072581	0	intersectin	62,73	ITSN	80,84	intersectin	ITSN	6453	6453	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure , sequence , and refined mapping of the human intersectin gene -LRB- ITSN -RRB- , which encompasses 250 kb on chromosome 21q22 .1 -- > q22 .2 .
9799604	0	intersectin	24,35	ITSN	37,41	intersectin	ITSN	6453	6453	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Two isoforms of a human intersectin -LRB- ITSN -RRB- protein are produced by brain-specific alternative splicing in a stop codon .
15631619	0	intersectin	112,123	stoned-B	82,90	intersectin	stoned-B	35378(Tax:7227)	4379834(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Molecular and genetic characterization of the interactions between the Drosophila stoned-B protein and DAP-160 -LRB- intersectin -RRB- .
24197061	0	intersectin_1	68,81	ROMK	33,37	intersectin 1	ROMK	6453	3758	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	MicroRNA-194 -LRB- miR-194 -RRB- regulates ROMK channel activity by targeting intersectin_1 .
11748279	0	intersectin_2	4,17	WASp	66,70	intersectin 2	WASp	50618	7454	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The intersectin_2 adaptor links Wiskott Aldrich_Syndrome protein -LRB- WASp -RRB- - mediated actin polymerization to T_cell_antigen_receptor endocytosis .
12361959	0	intersex	0,8	doublesex	126,135	intersex	doublesex	45881(Tax:7227)	40940(Tax:7227)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	intersex , a gene required for female sexual development in Drosophila , is expressed in both sexes and functions together with doublesex to regulate terminal differentiation .
9989817	0	interstitial_collagenase	67,91	parathyroid_hormone	95,114	interstitial collagenase	parathyroid hormone	17386(Tax:10090)	19226(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY required|nmod|induction required|nmod|END_ENTITY	Both AP-1 and Cbfa1-like factors are required for the induction of interstitial_collagenase by parathyroid_hormone .
10372988	0	interstitial_retinoid-binding_protein	47,84	IRBP	86,90	interstitial retinoid-binding protein	IRBP	5949	5949	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Elements regulating the transcription of human interstitial_retinoid-binding_protein -LRB- IRBP -RRB- gene in cultured retinoblastoma cells .
15774940	0	intestinal_alkaline_phosphatase	27,58	Cdx1	78,82	intestinal alkaline phosphatase	Cdx1	248	1044	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of intestinal_alkaline_phosphatase gene expression by Cdx1 and Cdx2 .
15831710	0	intestinal_alkaline_phosphatase	50,81	HNF-4	94,99	intestinal alkaline phosphatase	HNF-4	248	3172	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Differentiation-dependent activation of the human intestinal_alkaline_phosphatase promoter by HNF-4 in intestinal cells .
25037223	0	intestinal_alkaline_phosphatase	54,85	Kruppel-like_factor_5	185,206	intestinal alkaline phosphatase	Kruppel-like factor 5	248	688	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The intestinal epithelial cell differentiation marker intestinal_alkaline_phosphatase -LRB- ALPi -RRB- is selectively induced by histone deacetylase inhibitors -LRB- HDACi -RRB- in colon_cancer cells in a Kruppel-like_factor_5 -LRB- KLF5 -RRB- - dependent manner .
26092983	0	intestinal_alkaline_phosphatase	54,85	Kruppel-like_factor_5	185,206	intestinal alkaline phosphatase	Kruppel-like factor 5	248	688	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The intestinal epithelial cell differentiation marker intestinal_alkaline_phosphatase -LRB- ALPi -RRB- is selectively induced by histone deacetylase inhibitors -LRB- HDACi -RRB- in colon_cancer cells in a Kruppel-like_factor_5 -LRB- KLF5 -RRB- - dependent manner .
21204605	0	intestinal_fatty_acid-binding_protein	88,125	I-FABP	127,133	intestinal fatty acid-binding protein	I-FABP	2169	2169	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Development of a high-specificity sandwich ELISA system for the quantification of human intestinal_fatty_acid-binding_protein -LRB- I-FABP -RRB- concentrations .
21321317	0	intestinal_trefoil_factor	27,52	Growth_hormone	0,14	intestinal trefoil factor	Growth hormone	25563(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Growth_hormone upregulates intestinal_trefoil_factor expression in the ileum of rats after y-radiation .
25776570	0	intestinal_trefoil_factor	22,47	ITF	49,52	intestinal trefoil factor	ITF	7033	7033	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Protective effects of intestinal_trefoil_factor -LRB- ITF -RRB- on gastric mucosal epithelium through activation of extracellular_signal-regulated_kinase_1 / 2 -LRB- ERK1/2 -RRB- .
16410243	0	intestinal_trefoil_factor	48,73	Vangl1	0,6	intestinal trefoil factor	Vangl1	7033	81839	Gene	Gene	acts|nmod|START_ENTITY acts|amod|END_ENTITY	Vangl1 protein acts as a downstream effector of intestinal_trefoil_factor -LRB- ITF -RRB- / TFF3 signaling and regulates wound healing of intestinal epithelium .
19236815	0	intracellular_adhesion_molecule-1	66,99	Vascular_endothelial_growth_factor	0,34	intracellular adhesion molecule-1	Vascular endothelial growth factor	281839(Tax:9913)	281572(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor up-regulates the expression of intracellular_adhesion_molecule-1 in retinal endothelial cells via reactive oxygen species , but not nitric_oxide .
11312920	0	intracellular_adhesion_molecule-1	86,119	leukocyte_function-associated_antigen-1	46,85	intracellular adhesion molecule-1	leukocyte function-associated antigen-1	25464(Tax:10116)	308995(Tax:10116)	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Novel p-arylthio_cinnamides as antagonists of leukocyte_function-associated_antigen-1 / intracellular_adhesion_molecule-1 interaction .
17089918	0	intracellular_adhesion_molecule_1	30,63	ICAM-1	65,71	intracellular adhesion molecule 1	ICAM-1	3383	3383	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The K469E polymorphism of the intracellular_adhesion_molecule_1 -LRB- ICAM-1 -RRB- gene is not associated with myocardial_infarction in Caucasians with type 2 diabetes .
3261877	0	intrinsic_factor	44,60	Epidermal_growth_factor	0,23	intrinsic factor	Epidermal growth factor	2694	1950	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- inhibits both intrinsic_factor secretion and acid secretion in histamine-stimulated isolated gastric glands .
235783	0	intrinsic_factor	36,52	IF	54,56	intrinsic factor	IF	2694	2694	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	The effect of duodenal juice on the intrinsic_factor -LRB- IF -RRB- activity in gastric juice .
11287214	0	intrinsic_factor	27,43	transcobalamin_II	47,64	intrinsic factor	transcobalamin II	2694	6948	Gene	Gene	Transfer|nmod|START_ENTITY Transfer|nmod|END_ENTITY	Transfer of cobalamin from intrinsic_factor to transcobalamin_II .
2556942	0	intrinsic_factor	23,39	transcobalamin_II	56,73	intrinsic factor	transcobalamin II	29319(Tax:10116)	64365(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Cobalamin release from intrinsic_factor and transfer to transcobalamin_II within the rat enterocyte .
7695633	0	intrinsic_factor	66,82	transcobalamin_II	27,44	intrinsic factor	transcobalamin II	2694	6948	Gene	Gene	comparison|nmod|START_ENTITY structure|dep|comparison structure|nmod|END_ENTITY	Genomic structure of human transcobalamin_II : comparison to human intrinsic_factor and transcobalamin_I .
15790882	0	involucrin	3,13	AP1	23,26	involucrin	AP1	3713	3726	Gene	Gene	site|amod|START_ENTITY site|compound|END_ENTITY	An involucrin promoter AP1 transcription factor binding site is required for expression of involucrin in the corneal epithelium in vivo .
17882273	0	involucrin	32,42	Fra-1	62,67	involucrin	Fra-1	3713	8061	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Synergistic activation of human involucrin gene expression by Fra-1 and p300 -- evidence for the presence of a multiprotein complex .
7759510	0	involucrin	59,69	Fra-1	21,26	involucrin	Fra-1	3713	8061	Gene	Gene	transcription|compound|START_ENTITY activate|dobj|transcription activate|nsubj|END_ENTITY	Fos-related_antigen -LRB- Fra-1 -RRB- , junB , and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol_ester effects on promoter activity .
9733728	0	involucrin	20,30	MEK3	84,88	involucrin	MEK3	3713	5606	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Regulation of human involucrin promoter activity by a protein kinase C , Ras , MEKK1 , MEK3 , p38/RK , AP1 signal transduction pathway .
11454875	0	involucrin	21,31	MEK6	0,4	involucrin	MEK6	3713	5608	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MEK6 regulates human involucrin gene expression via a p38alpha - and p38delta - dependent mechanism .
11454875	0	involucrin	21,31	p38alpha	54,62	involucrin	p38alpha	3713	1432	Gene	Gene	expression|compound|START_ENTITY expression|nmod|mechanism mechanism|amod|END_ENTITY	MEK6 regulates human involucrin gene expression via a p38alpha - and p38delta - dependent mechanism .
7796919	0	inwardly-rectifying-K-channel	42,71	KCNJ6	78,83	inwardly-rectifying-K-channel	KCNJ6	3758	3763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization and variation of a human inwardly-rectifying-K-channel gene -LRB- KCNJ6 -RRB- : a putative ATP-sensitive K-channel subunit .
25427998	0	irisin	7,13	FNDC5	0,5	irisin	FNDC5	252995	252995	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	FNDC5 -LRB- irisin -RRB- gene and exceptional longevity : a functional replication study with rs16835198 and rs726344 SNPs .
24642356	0	irisin	60,66	Fndc5	47,52	irisin	Fndc5	252995	252995	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Exercise-mimicking treatment fails to increase Fndc5 mRNA _ irisin secretion in primary human myotubes .
25934839	0	irisin	33,39	SMAD3	0,5	irisin	SMAD3	252995	4088	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor y coactivator 1-a -LRB- PGC-1a -RRB- during exercise .
24057291	0	irisin	12,18	insulin	34,41	irisin	insulin	252995	3630	Gene	Gene	START_ENTITY|nmod|relation relation|nmod|resistance resistance|compound|END_ENTITY	Circulating irisin in relation to insulin resistance and the metabolic_syndrome .
24573684	0	iron-sulfur_cluster_scaffold_protein	71,107	ISCU	109,113	iron-sulfur cluster scaffold protein	ISCU	27247	27247	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	The presence of multiple cellular defects associated with a novel G50E iron-sulfur_cluster_scaffold_protein -LRB- ISCU -RRB- mutation leads to development of mitochondrial_myopathy .
24909164	0	iron_regulatory_protein_1	73,98	SIRT3	0,5	iron regulatory protein 1	SIRT3	48	23410	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron_regulatory_protein_1 .
24909164	0	iron_regulatory_protein_1	73,98	SIRT3	0,5	iron regulatory protein 1	SIRT3	48	23410	Gene	Gene	repressing|dobj|START_ENTITY regulates|advcl|repressing regulates|nsubj|END_ENTITY	SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron_regulatory_protein_1 .
21566147	0	iron_regulatory_protein_2	38,63	Iron_regulatory_protein_1	0,25	iron regulatory protein 2	Iron regulatory protein 1	64602(Tax:10090)	11428(Tax:10090)	Gene	Gene	outcompetes|dobj|START_ENTITY outcompetes|nsubj|END_ENTITY	Iron_regulatory_protein_1 outcompetes iron_regulatory_protein_2 in regulating cellular iron homeostasis in response to nitric_oxide .
1377452	0	irp	46,49	wnt-2	39,44	irp	wnt-2	25402(Tax:10116)	114487(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Growth and developmental regulation of wnt-2 -LRB- irp -RRB- gene in mesenchymal cells of fetal lung .
26472045	0	irx1b	83,88	mnx	56,59	irx1b	mnx	114430(Tax:7955)	3892	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	Pronephric tubule morphogenesis in zebrafish depends on mnx mediated repression of irx1b within the intermediate mesoderm .
7789634	0	islet-1	45,52	LIM/homeodomain	24,39	islet-1	LIM/homeodomain	3670	10611	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM .
2572523	0	islet-activating_protein	10,34	IAP	36,39	islet-activating protein	IAP	29364(Tax:10116)	29364(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of islet-activating_protein -LRB- IAP -RRB- on glucagon release from isolated perifused rat islets .
2695283	0	islet-activating_protein	14,38	IAP	40,43	islet-activating protein	IAP	29364(Tax:10116)	29364(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of islet-activating_protein -LRB- IAP -RRB- of pertussis toxin on the spontaneous diabetic_syndrome in the rat .
7030721	0	islet-activating_protein	10,34	IAP	36,39	islet-activating protein	IAP	3375	3375	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of islet-activating_protein -LRB- IAP -RRB- upon insulin secretion from human pancreatic islets .
7030721	0	islet-activating_protein	10,34	insulin	46,53	islet-activating protein	insulin	3375	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of islet-activating_protein -LRB- IAP -RRB- upon insulin secretion from human pancreatic islets .
9933567	0	islet-brain_1	64,77	JIP-1	135,140	islet-brain 1	JIP-1	9479	9479	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization , fine-mapping , and expression of the human islet-brain_1 -LRB- IB1 -RRB- / c-Jun-amino-terminal_kinase_interacting_protein-1 -LRB- JIP-1 -RRB- gene .
14507925	0	islet-brain_1	74,87	JNK	53,56	islet-brain 1	JNK	9479	5599	Gene	Gene	scaffold|xcomp|START_ENTITY scaffold|nsubj|degradation degradation|nmod|END_ENTITY	Calcium - and proteasome-dependent degradation of the JNK scaffold protein islet-brain_1 .
14561487	0	islet-brain_1	26,39	JNK	4,7	islet-brain 1	JNK	116457(Tax:10116)	116554(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY domain|nmod|activity domain|compound|END_ENTITY	The JNK binding domain of islet-brain_1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines .
14561487	0	islet-brain_1	26,39	JNK	62,65	islet-brain 1	JNK	116457(Tax:10116)	116554(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	The JNK binding domain of islet-brain_1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines .
9933567	0	islet-brain_1	64,77	c-Jun-amino-terminal_kinase_interacting_protein-1	84,133	islet-brain 1	c-Jun-amino-terminal kinase interacting protein-1	9479	9479	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Genomic organization , fine-mapping , and expression of the human islet-brain_1 -LRB- IB1 -RRB- / c-Jun-amino-terminal_kinase_interacting_protein-1 -LRB- JIP-1 -RRB- gene .
12697028	0	islet-cell_antigen_512	123,145	IA-2beta	166,174	islet-cell antigen 512	IA-2beta	5798	5799	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell_antigen_512 -LRB- IA-2 -RRB- and phogrin -LRB- IA-2beta -RRB- .
18753309	0	islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein	24,94	Foxa2	0,5	islet-specific glucose-6-phosphatase catalytic subunit-related protein	Foxa2	57818	3170	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Foxa2 and MafA regulate islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein gene expression .
11297555	0	islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein	50,120	IGRP	122,126	islet-specific glucose-6-phosphatase catalytic subunit-related protein	IGRP	681817(Tax:10116)	681817(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Cloning and characterization of the human and rat islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein -LRB- IGRP -RRB- genes .
15180990	0	islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein	27,97	Pax-6	120,125	islet-specific glucose-6-phosphatase catalytic subunit-related protein	Pax-6	14378(Tax:10090)	18508(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene transcription|nsubj|regulation transcription|nmod|END_ENTITY	Differential regulation of islet-specific_glucose-6-phosphatase_catalytic_subunit-related_protein gene transcription by Pax-6 and Pdx-1 .
20960024	0	islet_1	39,46	OCT1	24,28	islet 1	OCT1	16392(Tax:10090)	18986(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	POU homeodomain protein OCT1 modulates islet_1 expression during cardiac differentiation of P19CL6 cells .
19616077	0	islet_brain_1	38,51	JNK-interacting_protein_1	12,37	islet brain 1	JNK-interacting protein 1	9479	9479	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of the JNK-interacting_protein_1 / islet_brain_1 in cell degeneration in Alzheimer_disease and diabetes .
17709882	0	islet_neogenesis-associated_protein	12,47	INGAP	49,54	islet neogenesis-associated protein	INGAP	5068	5068	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of islet_neogenesis-associated_protein -LRB- INGAP -RRB- in islet neogenesis .
9151782	0	islet_neogenesis_associated_protein	41,76	INGAP	78,83	islet neogenesis associated protein	INGAP	5068	5068	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and sequencing of the pancreatic islet_neogenesis_associated_protein -LRB- INGAP -RRB- gene and its expression in islet neogenesis in hamsters .
22076165	0	isocitrate_dehydrogenase_1	65,91	IDH1	93,97	isocitrate dehydrogenase 1	IDH1	3417	3417	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Glioblastoma with PNET-like components has a higher frequency of isocitrate_dehydrogenase_1 -LRB- IDH1 -RRB- mutation and likely a better prognosis than primary_glioblastoma .
23235339	0	isocitrate_dehydrogenase_1	37,63	IDH1	65,69	isocitrate dehydrogenase 1	IDH1	3417	3417	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Immunohistochemical demonstration of isocitrate_dehydrogenase_1 -LRB- IDH1 -RRB- mutation in a small subset of prostatic_carcinomas .
23934769	0	isocitrate_dehydrogenase_1	45,71	IDH1	39,43	isocitrate dehydrogenase 1	IDH1	3417	3417	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	An analysis of the prognostic value of IDH1 -LRB- isocitrate_dehydrogenase_1 -RRB- mutation in Polish glioma patients .
23263745	0	isocitrate_dehydrogenase_2	45,71	HIF-1a	25,31	isocitrate dehydrogenase 2	HIF-1a	3418	3091	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	MicroRNA-183 upregulates HIF-1a by targeting isocitrate_dehydrogenase_2 -LRB- IDH2 -RRB- in glioma cells .
23815907	0	isocitrate_dehydrogenase_2	13,39	IDH2	41,45	isocitrate dehydrogenase 2	IDH2	3418	3418	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Mutation of isocitrate_dehydrogenase_2 -LRB- IDH2 -RRB- gene in Chinese AML patients and its clinical significance -RSB- .
12006387	0	isoprenylcysteine_carboxyl_methyltransferase	8,52	vascular_cell_adhesion_molecule-1	113,146	isoprenylcysteine carboxyl methyltransferase	vascular cell adhesion molecule-1	23463	7412	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of isoprenylcysteine_carboxyl_methyltransferase in tumor_necrosis_factor-alpha stimulation of expression of vascular_cell_adhesion_molecule-1 in endothelial cells .
17576084	0	isovaleryl-CoA_dehydrogenase	35,63	IVD	65,68	isovaleryl-CoA dehydrogenase	IVD	3712	3712	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Different spectrum of mutations of isovaleryl-CoA_dehydrogenase -LRB- IVD -RRB- gene in Korean patients with isovaleric_acidemia .
17137798	0	itch	40,44	Ndfip1	0,6	itch	Ndfip1	16396(Tax:10090)	65113(Tax:10090)	Gene	Gene	ubiquitin|compound|START_ENTITY function|nmod|ubiquitin ligase|nsubj|function promotes|ccomp|ligase promotes|nsubj|protein protein|amod|END_ENTITY	Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation .
21655234	0	itch	78,82	Pirt	0,4	itch	Pirt	16396(Tax:10090)	193003(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Pirt , a TRPV1 modulator , is required for histamine-dependent and - independent itch .
21460831	0	itch	93,97	TRPA1	0,5	itch	TRPA1	16396(Tax:10090)	277328(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	TRPA1 is required for histamine-independent , Mas-related G protein-coupled receptor-mediated itch .
11782481	0	itch	103,107	occludin	36,44	itch	occludin	83737	100506658	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch .
19393188	0	jagged-1	17,25	TNF	0,3	jagged-1	TNF	182	7124	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent .
21331358	0	jak3	98,102	rag-2	92,97	jak3	rag-2	3718	5897	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2 / jak3 double-deficient mice .
16959246	0	janus_kinase_2	97,111	JAK2	113,117	janus kinase 2	JAK2	3717	3717	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chronic_idiopathic_myelofibrosis -LRB- CIMF -RRB- resulting from a unique 3 ; 9 translocation disrupting the janus_kinase_2 -LRB- JAK2 -RRB- gene .
11178937	0	janus_kinase_2	115,129	b42	152,155	janus kinase 2	b42	16452(Tax:10090)	108767(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	LPS induction of I_kappa_B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus_kinase_2 inhibitor , Tyrphostin b42 .
24923444	0	janus_kinase_2	16,30	c-Abl	0,5	janus kinase 2	c-Abl	16452(Tax:10090)	11350(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	c-Abl activates janus_kinase_2 in normal hematopoietic cells .
9485044	0	janus_kinase_2	56,70	interferon-gamma	149,165	janus kinase 2	interferon-gamma	3717	3458	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Human malignant mesothelioma cell growth : activation of janus_kinase_2 and signal_transducer_and_activator_of_transcription_1alpha for inhibition by interferon-gamma .
9092791	0	janus_kinase_2	30,44	leptin_receptor	4,19	janus kinase 2	leptin receptor	16452(Tax:10090)	16847(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The leptin_receptor activates janus_kinase_2 and signals for proliferation in a factor-dependent cell line .
20921429	0	janus_kinase_2	96,110	signal_transducer_and_activator_of_transcription_3	111,161	janus kinase 2	signal transducer and activator of transcription 3	16452(Tax:10090)	20848(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Interleukin_6 knockout prevents angiotensin_II hypertension : role of renal vasoconstriction and janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 activation .
1692389	0	jimpy	8,13	Quaking	0,7	jimpy	Quaking	18823(Tax:10090)	19317(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Quaking * jimpy double mutant mice : additional evidence for independence of primary deficits in jimpy .
19010785	0	jumonji	2,9	Jarid2	11,17	jumonji	Jarid2	3720	3720	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	A jumonji -LRB- Jarid2 -RRB- protein complex represses cyclin_D1 expression by methylation of histone H3-K9 .
9218873	0	jun	131,134	activator_protein_1	155,174	jun	activator protein 1	3725	3725	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Transcriptional regulation of intercellular_adhesion_molecule_1 by phorbol_ester in human neuroblastoma cell line SK-N-SH involves jun - and fos-containing activator_protein_1 site binding complex -LRB- es -RRB- .
8619836	0	jun	14,17	erythropoietin	64,78	jun	erythropoietin	3725	2056	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of jun expression and activation of AP-1 activity by erythropoietin .
15387548	0	jun	36,39	fos	90,93	jun	fos	3725	2353	Gene	Gene	assembly|nmod|START_ENTITY peptides|nsubj|assembly peptides|nmod|dendrimer dendrimer|acl|displaying displaying|dobj|peptides peptides|compound|END_ENTITY	Noncovalent multivalent assembly of jun peptides on a leucine zipper dendrimer displaying fos peptides .
1923517	0	jun	14,17	fos	46,49	jun	fos	424673(Tax:9031)	396512(Tax:9031)	Gene	Gene	transformation|compound|START_ENTITY transformation|nmod|gene gene|compound|END_ENTITY	Inhibition of jun transformation by a mutated fos gene : design of an anti-oncogene .
21559685	0	jun	35,38	fos	30,33	jun	fos	3725	2353	Gene	Gene	START_ENTITY|nsubj|study study|nmod|gli gli|appos|END_ENTITY	A study on the oncogenes gli , fos , jun and met in human uterine leiomyomas .
21559685	0	jun	35,38	gli	25,28	jun	gli	3725	2735	Gene	Gene	START_ENTITY|nsubj|study study|nmod|END_ENTITY	A study on the oncogenes gli , fos , jun and met in human uterine leiomyomas .
12928942	0	jun	73,76	junB	112,116	jun	junB	3725	3726	Gene	Gene	quantitation|nmod|START_ENTITY RT-PCR|nmod|quantitation Comparison|nmod|RT-PCR protooncogene|nsubj|Comparison protooncogene|dobj|mRNA mRNA|nmod|expression expression|amod|END_ENTITY	-LSB- Comparison of conventional and real-time RT-PCR for the quantitation of jun protooncogene mRNA and analysis of junB mRNA expression in synovial membranes and isolated synovial fibroblasts from rheumatoid_arthritis patients -RSB- .
1712226	0	jun	14,17	macrophage_colony-stimulating_factor	68,104	jun	macrophage colony-stimulating factor	3725	1435	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of jun and fos gene expression in human monocytes by the macrophage_colony-stimulating_factor .
10678584	0	jun-N-terminal_kinase	141,162	Glutathione-S-Transferase	0,25	jun-N-terminal kinase	Glutathione-S-Transferase	5599	373156	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|dep|signaling	Glutathione-S-Transferase as a selective inhibitor of oncogenic ras-p21-induced mitogenic signaling through blockade of activation of jun by jun-N-terminal_kinase .
15149338	0	jun-N-terminal_kinase	0,21	PAI-1	49,54	jun-N-terminal kinase	PAI-1	5599	5054	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	jun-N-terminal_kinase regulates thrombin-induced PAI-1 gene expression in proximal tubular epithelial cells .
9737720	0	junB	69,73	c-fos	55,60	junB	c-fos	3726	2353	Gene	Gene	zif-268|amod|START_ENTITY END_ENTITY|amod|zif-268	Glucose and glucoincretin peptides synergize to induce c-fos , c-jun , junB , zif-268 , and nur-77 gene expression in pancreatic beta -LRB- INS-1 -RRB- cells .
7836389	0	junB	77,81	interleukin-6	107,120	junB	interleukin-6	16477(Tax:10090)	16193(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|acl|induced induced|nmod|END_ENTITY	Two distinct signalling pathways are involved in the control of the biphasic junB transcription induced by interleukin-6 in the B cell hybridoma 7TD1 .
12928942	0	junB	112,116	jun	73,76	junB	jun	3726	3725	Gene	Gene	expression|amod|START_ENTITY mRNA|nmod|expression protooncogene|dobj|mRNA protooncogene|nsubj|Comparison Comparison|nmod|RT-PCR RT-PCR|nmod|quantitation quantitation|nmod|END_ENTITY	-LSB- Comparison of conventional and real-time RT-PCR for the quantitation of jun protooncogene mRNA and analysis of junB mRNA expression in synovial membranes and isolated synovial fibroblasts from rheumatoid_arthritis patients -RSB- .
8032680	0	jun_B	53,58	Thyrotropin-releasing_hormone	0,29	jun B	Thyrotropin-releasing hormone	24517(Tax:10116)	25569(Tax:10116)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulates in parallel jun_B and c-fos messenger ribonucleic acids in GH3B6 pituitary cells : comparison with PRL secretion .
10449033	0	jun_N-terminal_kinase	63,84	p53	25,28	jun N-terminal kinase	p53	116554(Tax:10116)	301300(Tax:10116)	Gene	Gene	level|nmod|START_ENTITY modulates|dobj|level modulates|nsubj|status status|nmod|gene gene|compound|END_ENTITY	Mutational status of the p53 gene modulates the basal level of jun_N-terminal_kinase and its inducibility by ultraviolet irradiation in A1-5 rat fibroblasts .
12953056	0	junctional_adhesion_molecule	4,32	JAM	34,37	junctional adhesion molecule	JAM	50848	50848	Gene	Gene	members|amod|START_ENTITY members|appos|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
12953056	0	junctional_adhesion_molecule	4,32	JAM-2	54,59	junctional adhesion molecule	JAM-2	50848	58494	Gene	Gene	members|amod|START_ENTITY members|amod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
12953056	0	junctional_adhesion_molecule	4,32	PAR-3	111,116	junctional adhesion molecule	PAR-3	50848	56288	Gene	Gene	members|amod|START_ENTITY associate|nsubj|members associate|nmod|END_ENTITY	The junctional_adhesion_molecule -LRB- JAM -RRB- family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3 : a possible role for JAMs in endothelial cell polarity .
23389628	0	junctional_adhesion_molecule-A	22,52	CD9	12,15	junctional adhesion molecule-A	CD9	50848	928	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Tetraspanin CD9 links junctional_adhesion_molecule-A to avb3 integrin to mediate basic_fibroblast_growth_factor-specific angiogenic signaling .
23588236	0	junctional_adhesion_molecule-A	27,57	JAM-A	59,64	junctional adhesion molecule-A	JAM-A	50848	50848	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mast cell tryptase reduces junctional_adhesion_molecule-A -LRB- JAM-A -RRB- expression in intestinal epithelial cells : implications for the mechanisms of barrier_dysfunction in irritable_bowel_syndrome .
22647687	0	junctional_adhesion_molecule-A	41,71	Transforming_growth_factor-b1	0,29	junctional adhesion molecule-A	Transforming growth factor-b1	50848	7040	Gene	Gene	START_ENTITY|nsubj|attenuates attenuates|amod|END_ENTITY	Transforming_growth_factor-b1 attenuates junctional_adhesion_molecule-A and contributes to breast_cancer cell invasion .
16195363	0	junctional_adhesion_molecule-C	12,42	JAM-C	44,49	junctional adhesion molecule-C	JAM-C	83700	83700	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of junctional_adhesion_molecule-C -LRB- JAM-C -RRB- in oxidized LDL-mediated leukocyte recruitment .
19060272	0	junctional_adhesion_molecule-C	42,72	JAM-C	74,79	junctional adhesion molecule-C	JAM-C	83700	83700	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression , localization , and function of junctional_adhesion_molecule-C -LRB- JAM-C -RRB- in human retinal pigment epithelium .
18602143	0	junctional_adhesion_molecule_A	58,88	prostate-specific_antigen	14,39	junctional adhesion molecule A	prostate-specific antigen	50848	354	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of prostate-specific_antigen expression by the junctional_adhesion_molecule_A .
16767690	0	junctional_adhesion_molecule_C	12,42	JAM-C	44,49	junctional adhesion molecule C	JAM-C	83964(Tax:10090)	83964(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of junctional_adhesion_molecule_C -LRB- JAM-C -RRB- in acute pancreatitis .
8608216	0	k-FGF	39,44	fibroblast_growth_factor-4	11,37	k-FGF	fibroblast growth factor-4	2249	2249	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of fibroblast_growth_factor-4 -LRB- k-FGF -RRB- on long-term cultures of human bone marrow cells .
11086538	0	k-casein	101,109	CSN3	111,115	k-casein	CSN3	281728(Tax:9913)	281728(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms -LRB- SNPs -RRB- within Bov-A2 SINE in the second intron of bovine and buffalo k-casein -LRB- CSN3 -RRB- gene .
25091943	0	k-casein	37,45	CSN3	31,35	k-casein	CSN3	281728(Tax:9913)	281728(Tax:9913)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Effect of polymorphisms in the CSN3 -LRB- k-casein -RRB- gene on milk production traits in Chinese Holstein Cattle .
11802993	0	k-ras	82,87	P53	70,73	k-ras	P53	3845	7157	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|appos|proteins	-LSB- Expression of surviving gene and its relationship with expression of P53 , c-myc , k-ras proteins in non-small-cell lung_cancer -RSB- .
11802993	0	k-ras	82,87	c-myc	75,80	k-ras	c-myc	3845	4609	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	-LSB- Expression of surviving gene and its relationship with expression of P53 , c-myc , k-ras proteins in non-small-cell lung_cancer -RSB- .
8143931	0	kFGF	91,95	TGF-alpha	71,80	kFGF	TGF-alpha	2249	7039	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	All-trans-retinoic_acid and hexamethylene_bisacetamide -LRB- HMBA -RRB- regulate TGF-alpha and Hst-1 / kFGF expression in differentiation sensitive but not in resistant human teratocarcinomas .
10876088	0	kNBC1	48,53	NBC1	37,41	kNBC1	NBC1	8671	8671	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Structural organization of the human NBC1 gene : kNBC1 is transcribed from an alternative promoter in intron 3 .
18561895	0	kRas	10,14	p53	92,95	kRas	p53	3845	7157	Gene	Gene	protects|nsubj|START_ENTITY protects|parataxis|role role|nmod|END_ENTITY	Activated kRas protects colon_cancer cells from cucurbitacin-induced apoptosis : the role of p53 and p21 .
25147605	0	k_Opioid_Receptor	38,55	KOR	57,60	k Opioid Receptor	KOR	4986	4986	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis and Pharmacology of a Novel k_Opioid_Receptor -LRB- KOR -RRB- Agonist with a 1,3,5-Trioxazatriquinane Skeleton .
15282317	0	kaiso	37,42	rapsyn	18,24	kaiso	rapsyn	56805(Tax:10090)	19400(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|compound|END_ENTITY	Regulation of the rapsyn promoter by kaiso and delta-catenin .
3875484	0	kallikrein	69,79	Hageman_factor	50,64	kallikrein	Hageman factor	9622	2161	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Surface-dependent activation of human factor XII -LRB- Hageman_factor -RRB- by kallikrein and its light chain .
11010966	0	kallikrein	31,41	KLK15	51,56	kallikrein	KLK15	9622	55554	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning of the human kallikrein 15 gene -LRB- KLK15 -RRB- .
15766562	0	kallikrein	47,57	KLK5	0,4	kallikrein	KLK5	9622	25818	Gene	Gene	family|compound|START_ENTITY members|nmod|family END_ENTITY|appos|members	KLK5 and KLK7 , two members of the human tissue kallikrein family , are differentially expressed in lung_cancer .
19085836	0	kallikrein	9,19	KLK_5	21,26	kallikrein	KLK 5	9622	25818	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Multiple kallikrein -LRB- KLK_5 , 7 , 8 , and 10 -RRB- expression in squamous_cell_carcinoma_of_the_oral_cavity .
6202319	0	kallikrein	28,38	alpha_2-macroglobulin	64,85	kallikrein	alpha 2-macroglobulin	9622	2	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human plasma kallikrein and its light chain with alpha_2-macroglobulin .
10999954	0	kallikrein	47,57	bradykinin	6,16	kallikrein	bradykinin	9622	3827	Gene	Gene	proteases|compound|START_ENTITY activated|nmod|proteases _|ccomp|activated _|nsubj|B B|compound|END_ENTITY	Human bradykinin B -LRB- 2 -RRB- _ receptor is activated by kallikrein and other serine proteases .
4627469	0	kallikrein	45,55	bradykinin	31,41	kallikrein	bradykinin	9622	3827	Gene	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|release release|nmod|END_ENTITY	The kinetics of the release of bradykinin by kallikrein in normal human plasma .
582675	0	kallikrein	23,33	bradykinin	42,52	kallikrein	bradykinin	9622	3827	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Antagonistic effect of kallikrein against bradykinin .
6566613	0	kallikrein	101,111	bradykinin	142,152	kallikrein	bradykinin	9622	3827	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Comparative evaluation of the action of nonsteroidal anti-inflammatory preparations on blood plasma kallikrein and the biological effects of bradykinin -RSB- .
4852471	0	kallikrein	36,46	dopa_decarboxylase	14,32	kallikrein	dopa decarboxylase	9622	1644	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of dopa_decarboxylase by kallikrein .
2439135	0	kallikrein	141,151	kallikrein	92,102	kallikrein	kallikrein	9622	9622	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of covalent binding of aprotinin with a polysaccharide carrier on its inhibition of kallikrein from human plasma , porcine pancreatic kallikrein and trypsin -RSB- .
2439135	0	kallikrein	92,102	kallikrein	141,151	kallikrein	kallikrein	9622	9622	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of covalent binding of aprotinin with a polysaccharide carrier on its inhibition of kallikrein from human plasma , porcine pancreatic kallikrein and trypsin -RSB- .
9761243	0	kallikrein	32,42	kallikrein	48,58	kallikrein	kallikrein	9622	9622	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	The precursor form of the human kallikrein 2 , a kallikrein homologous to prostate-specific_antigen , is present in human sera and is increased in prostate_cancer and benign_prostatic_hyperplasia .
9761243	0	kallikrein	48,58	kallikrein	32,42	kallikrein	kallikrein	9622	9622	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	The precursor form of the human kallikrein 2 , a kallikrein homologous to prostate-specific_antigen , is present in human sera and is increased in prostate_cancer and benign_prostatic_hyperplasia .
10991942	0	kallikrein	148,158	kallistatin	44,55	kallikrein	kallistatin	9622	5267	Gene	Gene	site|nmod|START_ENTITY acting|nmod|site enhance|advcl|acting charged|advcl|enhance charged|nmod|surface surface|nmod|functions functions|compound|END_ENTITY	A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein .
10991942	0	kallikrein	84,94	kallistatin	44,55	kallikrein	kallistatin	9622	5267	Gene	Gene	inhibition|compound|START_ENTITY enhance|dobj|inhibition charged|advcl|enhance charged|nmod|surface surface|nmod|functions functions|compound|END_ENTITY	A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein .
9826127	0	kallikrein	48,58	kallistatin	25,36	kallikrein	kallistatin	9622	5267	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands .
2087934	0	kallikrein	34,44	renin	7,12	kallikrein	renin	9622	5972	Gene	Gene	excretion|compound|START_ENTITY END_ENTITY|dobj|excretion	Plasma renin activity and urinary kallikrein excretion in response to intravenous furosemide in diabetic patients .
2676859	0	kallikrein	35,45	renin	62,67	kallikrein	renin	9622	5972	Gene	Gene	activity|compound|START_ENTITY activity|nmod|hypertension hypertension|amod|END_ENTITY	Mechanisms of suppression of renal kallikrein activity in low renin essential hypertension and renoparenchymal hypertension .
6432545	0	kallikrein	43,53	renin	150,155	kallikrein	renin	9622	5972	Gene	Gene	excretion|compound|START_ENTITY measurement|nmod|excretion measurement|dep|relation relation|nmod|END_ENTITY	Direct and indirect measurement of urinary kallikrein excretion in patients with essential hypertension and normotensives : relation to age and plasma renin and aldosterone levels .
7007236	0	kallikrein	17,27	renin	84,89	kallikrein	renin	9622	5972	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|activity activity|compound|END_ENTITY	Abnormal urinary kallikrein in hypertension is not related to aldosterone or plasma renin activity .
7008062	0	kallikrein	11,21	renin	72,77	kallikrein	renin	9622	5972	Gene	Gene	renin|dep|START_ENTITY plasma|nsubj|renin plasma|dobj|END_ENTITY	The renin -- kallikrein -- prostaglandin system : plasma active and inactive renin and urinary kallikrein during prostacyclin infusion in man .
7021413	0	kallikrein	47,57	renin	32,37	kallikrein	renin	9622	5972	Gene	Gene	role|nmod|START_ENTITY Mechanism|dep|role Mechanism|nmod|acid-activation acid-activation|nmod|END_ENTITY	Mechanism of acid-activation of renin : role of kallikrein in renin activation .
7021413	0	kallikrein	47,57	renin	61,66	kallikrein	renin	9622	5972	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Mechanism of acid-activation of renin : role of kallikrein in renin activation .
7037811	0	kallikrein	69,79	renin	40,45	kallikrein	renin	9622	5972	Gene	Gene	Responses|nmod|START_ENTITY Responses|nmod|END_ENTITY	Responses of active and inactive plasma renin and changes in urinary kallikrein and plasma prekallikrein to various conditions in normal subjects .
7584907	0	kallikrein	14,24	renin	69,74	kallikrein	renin	9622	5972	Gene	Gene	generate|nsubj|START_ENTITY generate|nmod|substrates substrates|amod|END_ENTITY	Human urinary kallikrein can generate angiotensin_II from homologous renin substrates .
912848	0	kallikrein	8,18	renin	29,34	kallikrein	renin	9622	5972	Gene	Gene	START_ENTITY|nmod|hypertension hypertension|amod|END_ENTITY	Urinary kallikrein in normal renin essential hypertension .
17257635	0	kallikrein-2_and_androgen_receptor	66,100	prostate_specific_antigen	39,64	kallikrein-2 and androgen receptor	prostate specific antigen	367	354	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Is there an inter-relationship between prostate_specific_antigen , kallikrein-2_and_androgen_receptor gene polymorphisms with risk of prostate_cancer in north Indian population ?
21487810	0	kallikrein-related_peptidase_10	47,78	KLK10	80,85	kallikrein-related peptidase 10	KLK10	5655	5655	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression analysis and clinical evaluation of kallikrein-related_peptidase_10 -LRB- KLK10 -RRB- in colorectal_cancer .
21057706	0	kallikrein-related_peptidase_14	62,93	KLK14	100,105	kallikrein-related peptidase 14	KLK14	43847	43847	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Quantitative expression analysis and study of the novel human kallikrein-related_peptidase_14 gene -LRB- KLK14 -RRB- in malignant and benign breast tissues .
21906360	0	kallikrein-related_peptidase_5	19,49	KLK5	51,55	kallikrein-related peptidase 5	KLK5	25818	25818	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Down-regulation of kallikrein-related_peptidase_5 -LRB- KLK5 -RRB- expression in breast_cancer patients : a biomarker for the differential diagnosis of breast_lesions .
22373580	0	kallikrein-related_peptidase_6	30,60	KLK6	62,66	kallikrein-related peptidase 6	KLK6	5653	5653	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation and secretion of kallikrein-related_peptidase_6 -LRB- KLK6 -RRB- in gastric_cancer .
23376368	0	kallikrein-related_peptidase_6	20,50	KLK6	52,56	kallikrein-related peptidase 6	KLK6	19144(Tax:10090)	19144(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	In vivo analysis of kallikrein-related_peptidase_6 -LRB- KLK6 -RRB- function in oligodendrocyte development and the expression of myelin proteins .
24643912	0	kallikrein-related_peptidase_6	56,86	proteinase-activated_receptor_2	105,136	kallikrein-related peptidase 6	proteinase-activated receptor 2	5653	2150	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Growth and survival of lung_cancer cells : regulation by kallikrein-related_peptidase_6 via activation of proteinase-activated_receptor_2 and the epidermal_growth_factor_receptor .
11920956	0	kallikrein_10	63,76	KLK10	78,83	kallikrein 10	KLK10	5655	5655	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of single nucleotide polymorphisms in the human kallikrein_10 -LRB- KLK10 -RRB- gene and their association with prostate , breast , testicular , and ovarian_cancers .
14568187	0	kallikrein_10	40,53	KLK10	55,60	kallikrein 10	KLK10	5655	5655	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Steroid hormone regulation of the human kallikrein_10 -LRB- KLK10 -RRB- gene in cancer cell lines and functional characterization of the KLK10 gene promoter .
16800741	0	kallikrein_11	34,47	KLK11	49,54	kallikrein 11	KLK11	11012	11012	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	mRNA expression analysis of human kallikrein_11 -LRB- KLK11 -RRB- may be useful in the discrimination of benign_prostatic_hyperplasia from prostate_cancer after needle prostate biopsy .
22429520	0	kallikrein_11	48,61	KLK11	63,68	kallikrein 11	KLK11	11012	11012	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Diagnostic and prognostic significance of human kallikrein_11 -LRB- KLK11 -RRB- mRNA expression levels in patients with laryngeal_cancer .
12845660	0	kallikrein_11	43,56	hK11	58,62	kallikrein 11	hK11	11012	11012	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Favorable prognostic value of tissue human kallikrein_11 -LRB- hK11 -RRB- in patients with ovarian_carcinoma .
15300858	0	kallikrein_12	46,59	KLK12	61,66	kallikrein 12	KLK12	43849	43849	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Splice-site genetic polymorphism of the human kallikrein_12 -LRB- KLK12 -RRB- gene correlates with no substantial expression of KLK12 protein having serine_protease activity .
20155713	0	kallikrein_14	6,19	KLK14	21,26	kallikrein 14	KLK14	43847	43847	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human kallikrein_14 -LRB- KLK14 -RRB- expression in salivary_gland_tumors .
22085651	0	kallikrein_1b26	16,31	klk1b26	33,40	kallikrein 1b26	klk1b26	13647(Tax:10090)	13647(Tax:10090)	Gene	Gene	translation|amod|START_ENTITY translation|appos|END_ENTITY	Interference of kallikrein_1b26 -LRB- klk1b26 -RRB- translation by microRNA specifically expressed in female mouse submandibular glands : an additional mechanism for sexual dimorphism of klk1b26 protein in the glands .
19299547	0	kallikrein_5	31,43	KLK5	45,49	kallikrein 5	KLK5	25818	25818	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Quantitative analysis of human kallikrein_5 -LRB- KLK5 -RRB- expression in prostate needle biopsies : an independent cancer biomarker .
11986781	0	kallikrein_gene_13	6,24	KLK13	26,31	kallikrein gene 13	KLK13	26085	26085	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Human kallikrein_gene_13 -LRB- KLK13 -RRB- expression by quantitative RT-PCR : an independent indicator of favourable prognosis in breast_cancer .
12858357	0	kallikrein_gene_14	37,55	KLK14	57,62	kallikrein gene 14	KLK14	43847	43847	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of the human kallikrein_gene_14 -LRB- KLK14 -RRB- in normal and cancerous prostatic tissues .
11948967	0	kallikrein_gene_5	29,46	KLK5	48,52	kallikrein gene 5	KLK5	25818	25818	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of the human kallikrein_gene_5 -LRB- KLK5 -RRB- in prostate_cancer tissues .
12142380	0	kallikrein_gene_5	6,23	KLK5	25,29	kallikrein gene 5	KLK5	25818	25818	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Human kallikrein_gene_5 -LRB- KLK5 -RRB- expression by quantitative PCR : an independent indicator of poor prognosis in breast_cancer .
12725415	0	kallikrein_gene_9	34,51	KLK9	53,57	kallikrein gene 9	KLK9	284366	284366	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The prognostic value of the human kallikrein_gene_9 -LRB- KLK9 -RRB- in breast_cancer .
16307483	0	kallikreins_5_and_7	20,39	lympho-epithelial_Kazal-type_inhibitor	73,111	kallikreins 5 and 7	lympho-epithelial Kazal-type inhibitor	25818	11005	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human kallikreins_5_and_7 by the serine protease inhibitor lympho-epithelial_Kazal-type_inhibitor -LRB- LEKTI -RRB- .
10991942	0	kallistatin	44,55	kallikrein	148,158	kallistatin	kallikrein	5267	9622	Gene	Gene	functions|compound|START_ENTITY surface|nmod|functions charged|nmod|surface charged|advcl|enhance enhance|advcl|acting acting|nmod|site site|nmod|END_ENTITY	A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein .
10991942	0	kallistatin	44,55	kallikrein	84,94	kallistatin	kallikrein	5267	9622	Gene	Gene	functions|compound|START_ENTITY surface|nmod|functions charged|nmod|surface charged|advcl|enhance enhance|dobj|inhibition inhibition|compound|END_ENTITY	A positively charged loop on the surface of kallistatin functions to enhance tissue kallikrein inhibition by acting as a secondary binding site for kallikrein .
9826127	0	kallistatin	25,36	kallikrein	48,58	kallistatin	kallikrein	5267	9622	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Cellular localization of kallistatin and tissue kallikrein in human pancreas and salivary glands .
26998012	0	kangai-1	63,71	microRNA-503	24,36	kangai-1	microRNA-503	3732	574506	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell_non-Hodgkin 's _ lymphoma .
15190947	0	kappa-casein	25,37	CSN3	39,43	kappa-casein	CSN3	100861231	100861231	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High polymorphism in the kappa-casein -LRB- CSN3 -RRB- gene from wild and domestic caprine species revealed by DNA sequencing .
17333943	0	kappa-casein	25,37	CSN3	44,48	kappa-casein	CSN3	281728(Tax:9913)	281728(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Allelic polymorphism of kappa-casein gene -LRB- CSN3 -RRB- in Russian cattle breeds and its informative value as a genetic marker -RSB- .
16431922	0	kappa_opioid_receptor	24,45	GEC1	0,4	kappa opioid receptor	GEC1	4986	23710	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GEC1 interacts with the kappa_opioid_receptor and enhances expression of the receptor .
15608558	0	kappa_opioid_receptor	26,47	OPRK1	54,59	kappa opioid receptor	OPRK1	4986	4986	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Redefinition of the human kappa_opioid_receptor gene -LRB- OPRK1 -RRB- structure and association of haplotypes with opiate_addiction .
17373729	0	kappa_opioid_receptor	6,27	OPRK1	34,39	kappa opioid receptor	OPRK1	4986	4986	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human kappa_opioid_receptor gene -LRB- OPRK1 -RRB- polymorphism is associated with opiate_addiction .
16085496	0	kar3	48,52	Cik1	0,4	kar3	Cik1	856263(Tax:4932)	855238(Tax:4932)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends .
23268335	0	karyopherin_a_2	43,58	KPNA2	60,65	karyopherin a 2	KPNA2	3838	3838	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The functional role of the novel biomarker karyopherin_a_2 -LRB- KPNA2 -RRB- in cancer .
11882654	0	karyopherin_alpha_2	20,39	PLAG1	60,65	karyopherin alpha 2	PLAG1	3838	5324	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Identification of a karyopherin_alpha_2 recognition site in PLAG1 , which functions as a nuclear localization signal .
17255955	0	karyopherin_alpha_2	27,46	TGF-beta1	61,70	karyopherin alpha 2	TGF-beta1	3838	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Differential regulation of karyopherin_alpha_2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes : evident contribution of KPNA2 for nuclear translocation of IRF-1 .
16293230	0	keap1	36,41	Nrf2	57,61	keap1	Nrf2	50868(Tax:10090)	18024(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY deletion|nmod|gene activates|nsubj|deletion activates|dobj|END_ENTITY	Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute_drug_toxicity .
18505935	0	keratin-14	69,79	CXCR2	119,124	keratin-14	CXCR2	16664(Tax:10090)	12765(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Short tail with skin_lesion phenotype occurs in transgenic_mice with keratin-14 promoter-directed expression of mutant CXCR2 .
21188418	0	keratin-74	23,33	KRT74	35,40	keratin-74	KRT74	121391	121391	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations in the keratin-74 -LRB- KRT74 -RRB- gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families .
22995344	0	keratin-associated_protein_24-1	44,75	KAP24-1	77,84	keratin-associated protein 24-1	KAP24-1	101116882	101116882	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and sequence analysis of the keratin-associated_protein_24-1 -LRB- KAP24-1 -RRB- gene homologue in sheep .
21771088	0	keratin-associated_protein_KAP1-2	28,61	KRTAP1-2	68,76	keratin-associated protein KAP1-2	KRTAP1-2	100294612(Tax:9940)	100294612(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the ovine keratin-associated_protein_KAP1-2 gene -LRB- KRTAP1-2 -RRB- .
11408568	0	keratin_10	89,99	keratins_5_and_14	68,85	keratin 10	keratins 5 and 14	16661(Tax:10090)	110308;16664	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Formation of a normal epidermis supported by increased stability of keratins_5_and_14 in keratin_10 null mice .
16352477	0	keratin_12	100,110	KRT12	112,117	keratin 12	KRT12	3859	3859	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Meesmann_corneal_dystrophy -LRB- MECD -RRB- : report of 2 families and a novel mutation in the cornea specific keratin_12 -LRB- KRT12 -RRB- gene .
18713255	0	keratin_14	82,92	KRT14	99,104	keratin 14	KRT14	3861	3861	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical heterogeneity in recessive_epidermolysis_bullosa due to mutations in the keratin_14 gene , KRT14 .
9804355	0	keratin_14	111,121	KRT14	128,133	keratin 14	KRT14	3861	3861	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Severe palmo-plantar_hyperkeratosis in Dowling-Meara epidermolysis_bullosa simplex caused by a mutation in the keratin_14 gene -LRB- KRT14 -RRB- .
10623468	0	keratin_15	15,25	transforming_growth_factor_beta	40,71	keratin 15	transforming growth factor beta	3866	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of keratin_15 expression by transforming_growth_factor_beta in vitro and by cutaneous injury in vivo .
12954631	0	keratin_16	32,42	epidermal_growth_factor	62,85	keratin 16	epidermal growth factor	3868	1950	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of disease-associated keratin_16 gene expression by epidermal_growth_factor is regulated through cooperation of transcription factors Sp1 and c-Jun .
21796151	0	keratin_17	19,29	IL-17A	0,6	keratin 17	IL-17A	16667(Tax:10090)	16171(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	IL-17A upregulates keratin_17 expression in keratinocytes through STAT1 - and STAT3-dependent mechanisms .
22808266	0	keratin_17	49,59	IL-22	30,35	keratin 17	IL-22	16667(Tax:10090)	50929(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	The pro-inflammatory cytokine IL-22 up-regulates keratin_17 expression in keratinocytes via STAT3 and ERK1/2 .
24438005	0	keratin_19	25,35	SIRT2	10,15	keratin 19	SIRT2	3880	22933	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Mammalian SIRT2 inhibits keratin_19 expression and is a tumor suppressor in skin .
9804344	0	keratin_2e	45,55	KRT2E	62,67	keratin 2e	KRT2E	3849	3849	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and fine mapping of the keratin_2e gene -LRB- KRT2E -RRB- : K2e V1 domain polymorphism and novel mutations in ichthyosis_bullosa_of_Siemens .
24994782	0	keratin_33B	23,34	androgen_receptor	74,91	keratin 33B	androgen receptor	450227(Tax:10116)	24208(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Testosterone regulates keratin_33B expression in rat penis growth through androgen_receptor signaling .
1377166	0	keratin_5	33,42	KRT5	44,48	keratin 5	KRT5	3852	3852	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regional assignment of the human keratin_5 -LRB- KRT5 -RRB- gene to chromosome 12q near D12S14 by PCR analysis of somatic cell hybrids and multicolor in situ hybridization .
26876307	0	keratin_8	76,85	Epithelial_membrane_protein_2	0,29	keratin 8	Epithelial membrane protein 2	3856	2013	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Epithelial_membrane_protein_2 regulates sphingosylphosphorylcholine-induced keratin_8 phosphorylation and reorganization : Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung_cancer cells .
19115206	0	keratin_8	19,28	PRL-3	55,60	keratin 8	PRL-3	3856	11156	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Down-modulation of keratin_8 phosphorylation levels by PRL-3 contributes to colorectal_carcinoma progression .
17553064	0	keratin_8	40,49	Protein_kinase_C_epsilon	0,24	keratin 8	Protein kinase C epsilon	25626(Tax:10116)	29340(Tax:10116)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Protein_kinase_C_epsilon phosphorylates keratin_8 at Ser8 and Ser23 in GH4C1 cells stimulated by thyrotropin-releasing_hormone .
18573708	0	keratin_9	22,31	KRT9	33,37	keratin 9	KRT9	3857	3857	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Identification of the keratin_9 -LRB- KRT9 -RRB- N161S mutation in a Chinese kindred with epidermolytic_palmoplantar_keratoderma .
9720175	0	keratin_9	39,48	KRT9	50,54	keratin 9	KRT9	490980(Tax:9615)	490980(Tax:9615)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and analysis of the dog keratin_9 -LRB- KRT9 -RRB- gene .
10026256	0	keratinocyte_growth_factor	39,65	Heparan_sulfate_proteoglycan	0,28	keratinocyte growth factor	Heparan sulfate proteoglycan	100761599	100689041	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Heparan_sulfate_proteoglycan modulates keratinocyte_growth_factor signaling through interaction with both ligand and receptor .
16120148	0	keratinocyte_growth_factor	27,53	Interleukin-19	0,14	keratinocyte growth factor	Interleukin-19	2252	29949	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Interleukin-19 upregulates keratinocyte_growth_factor and is associated with psoriasis .
10873663	0	keratinocyte_growth_factor	35,61	KGF	69,72	keratinocyte growth factor	KGF	2252	2252	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Vitamin_D induced up-regulation of keratinocyte_growth_factor -LRB- FGF-7 / KGF -RRB- in MCF-7 human breast_cancer cells .
1696274	0	keratinocyte_growth_factor	6,32	KGF	142,145	keratinocyte growth factor	KGF	2252	2252	Gene	Gene	activity|compound|START_ENTITY activity|dep|END_ENTITY	Human keratinocyte_growth_factor activity on proliferation and differentiation of human keratinocytes : differentiation response distinguishes KGF from EGF family .
20213138	0	keratinocyte_growth_factor	45,71	KGF	73,76	keratinocyte growth factor	KGF	2252	2252	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of tumour-cell-derived or recombinant keratinocyte_growth_factor -LRB- KGF -RRB- on proliferation and radioresponse of human epithelial_tumour cells -LRB- HNSCC -RRB- and normal keratinocytes in vitro .
9430821	0	keratinocyte_growth_factor	23,49	KGF	51,54	keratinocyte growth factor	KGF	403915(Tax:9615)	403915(Tax:9615)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Differential effect of keratinocyte_growth_factor -LRB- KGF -RRB- on aromatase activity in cultured canine prostatic epithelial cells .
9614385	0	keratinocyte_growth_factor	11,37	KGF	39,42	keratinocyte growth factor	KGF	29348(Tax:10116)	29348(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of keratinocyte_growth_factor -LRB- KGF -RRB- on gut growth and repair .
15307144	0	keratinocyte_growth_factor	14,40	fibroblast_growth_factor-7	41,67	keratinocyte growth factor	fibroblast growth factor-7	2252	2252	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of keratinocyte_growth_factor / fibroblast_growth_factor-7 and its receptor in human lung_cancer : correlation with tumour proliferative activity and patient prognosis .
7511604	0	keratinocyte_growth_factor	14,40	interleukin_1	60,73	keratinocyte growth factor	interleukin 1	2252	3552	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of keratinocyte_growth_factor gene expression by interleukin_1 .
20815256	0	keratinocyte_growth_factor_2	12,40	KGF2	47,51	keratinocyte growth factor 2	KGF2	2255	2255	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Cloning of keratinocyte_growth_factor_2 gene -LRB- KGF2 -RRB- and its transformation to Brassica_napus_L -RSB- .
12529371	0	keratinocyte_growth_factor_receptor	57,92	p21-activated_protein_kinase_4	0,30	keratinocyte growth factor receptor	p21-activated protein kinase 4	2263	10298	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	p21-activated_protein_kinase_4 -LRB- PAK4 -RRB- interacts with the keratinocyte_growth_factor_receptor and participates in keratinocyte_growth_factor-mediated inhibition of oxidant-induced cell death .
7509717	0	keratins_1_and_10	115,132	Ornithine_decarboxylase	0,23	keratins 1 and 10	Ornithine decarboxylase	16678;16661	18263(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|amod|END_ENTITY	Ornithine_decarboxylase expression in cutaneous_papillomas in SENCAR mice is associated with altered expression of keratins_1_and_10 .
11408568	0	keratins_5_and_14	68,85	keratin_10	89,99	keratins 5 and 14	keratin 10	110308;16664	16661(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Formation of a normal epidermis supported by increased stability of keratins_5_and_14 in keratin_10 null mice .
26521124	0	ketohexokinase	128,142	KHK	144,147	ketohexokinase	KHK	3795	3795	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Pharmacophore modeling , virtual screening , molecular docking studies and density functional theory approaches to identify novel ketohexokinase -LRB- KHK -RRB- inhibitors .
9917396	0	kettin	15,21	actin	27,32	kettin	actin	44013(Tax:7227)	40444(Tax:7227)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of kettin with actin in the Z-disc of insect flight muscle .
1991048	0	kidney_androgen-regulated_protein	51,84	KAP	86,89	kidney androgen-regulated protein	KAP	16483(Tax:10090)	16483(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and DNA sequence of the mouse kidney_androgen-regulated_protein -LRB- KAP -RRB- gene .
21153285	0	kidney_androgen-regulated_protein	49,82	KAP	84,87	kidney androgen-regulated protein	KAP	24937(Tax:10116)	24937(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Cell-specific and hormonal regulation of the rat kidney_androgen-regulated_protein -LRB- KAP -RRB- gene .
18423496	0	kif7	62,66	kinesin_superfamily7	40,60	kif7	kinesin superfamily7	101158754	101158754	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Cloning and developmental expression of kinesin_superfamily7 -LRB- kif7 -RRB- in the brackish medaka -LRB- Oryzias melastigma -RRB- , a close relative of the Japanese_medaka -LRB- Oryzias_latipes -RRB- .
16671942	0	killer-cell_immunoglobulin-like_receptor	16,56	KIR	58,61	killer-cell immunoglobulin-like receptor	KIR	3806	3806	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of killer-cell_immunoglobulin-like_receptor -LRB- KIR -RRB- in Comoros and Southeast France .
16818466	0	killer_cell_Ig-like_receptor	67,95	KIR	97,100	killer cell Ig-like receptor	KIR	553128	553128	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional redundancy of transcription factor-binding sites in the killer_cell_Ig-like_receptor -LRB- KIR -RRB- gene promoter .
17579070	0	killer_cell_Ig-like_receptor	13,41	KIR	43,46	killer cell Ig-like receptor	KIR	553128	553128	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Evolution of killer_cell_Ig-like_receptor -LRB- KIR -RRB- genes : definition of an orangutan KIR haplotype reveals expansion of lineage III KIR associated with the emergence of MHC-C .
21542807	0	killer_cell_immunoglobulin-like_receptor	16,56	HLA-C	85,90	killer cell immunoglobulin-like receptor	HLA-C	3806	3107	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	Distribution of killer_cell_immunoglobulin-like_receptor genes and combinations with HLA-C ligands in an isolated Han population in southwest China .
12493005	0	killer_cell_immunoglobulin-like_receptor	4,44	KIR	46,49	killer cell immunoglobulin-like receptor	KIR	3806	3806	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	The killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genomic region : gene-order , haplotypes and allelic polymorphism .
18668235	0	killer_cell_immunoglobulin-like_receptor	59,99	KIR	101,104	killer cell immunoglobulin-like receptor	KIR	3806	3806	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Asian population frequencies and haplotype distribution of killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genes among Chinese , Malay , and Indian in Singapore .
19309280	0	killer_cell_immunoglobulin-like_receptor	16,56	KIR	58,61	killer cell immunoglobulin-like receptor	KIR	3806	3806	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genotypes in patients with familial_Mediterranean_fever .
20033655	0	killer_cell_immunoglobulin-like_receptor	76,116	KIR	118,121	killer cell immunoglobulin-like receptor	KIR	3806	3806	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Identification and analysis of novel transcripts and promoters in the human killer_cell_immunoglobulin-like_receptor -LRB- KIR -RRB- genes .
18687225	0	killer_cell_immunoglobulin_like_receptor	30,70	KIR	72,75	killer cell immunoglobulin like receptor	KIR	3806	3806	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Study on the polymorphism of killer_cell_immunoglobulin_like_receptor -LRB- KIR -RRB- gene with systemic_lupus_erythematosus of North population in China -RSB- .
20663776	0	killer_cell_lectin-like_receptor_F1	116,151	activation-induced_C-type_lectin	67,99	killer cell lectin-like receptor F1	activation-induced C-type lectin	51348	9976	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Tumor cells of non-hematopoietic and hematopoietic origins express activation-induced_C-type_lectin , the ligand for killer_cell_lectin-like_receptor_F1 .
15879103	0	killer_cell_lectin-like_receptor_G1	14,49	CD8	76,79	killer cell lectin-like receptor G1	CD8	10219	925	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	Expression of killer_cell_lectin-like_receptor_G1 on antigen-specific human CD8 + T lymphocytes during active , latent , and resolved_infection and its relation with CD57 .
23325888	0	killer_cell_lectin-like_receptor_G1	34,69	CD8	86,89	killer cell lectin-like receptor G1	CD8	10219	925	Gene	Gene	cells|amod|START_ENTITY cells|nummod|END_ENTITY	Id2 influences differentiation of killer_cell_lectin-like_receptor_G1 -LRB- hi -RRB- short-lived CD8 + effector T cells .
11220622	0	killer_cell_lectin-like_receptor_G1	69,104	KLRG1	111,116	killer cell lectin-like receptor G1	KLRG1	50928(Tax:10090)	50928(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure , alternative splicing , and physical mapping of the killer_cell_lectin-like_receptor_G1 gene -LRB- KLRG1 -RRB- , the mouse homologue of MAFA .
10803839	0	killer_immunoglobulin-like_receptor	54,89	KIR	91,94	killer immunoglobulin-like receptor	KIR	3805	3805	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The genomic organization and evolution of the natural killer_immunoglobulin-like_receptor -LRB- KIR -RRB- gene cluster .
21114902	0	killer_immunoglobulin-like_receptor	31,66	KIR	68,71	killer immunoglobulin-like receptor	KIR	3805	3805	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of donor-derived killer_immunoglobulin-like_receptor -LRB- KIR -RRB- by sequential genotyping in hematopoietic stem cell-transplanted patients .
15833103	0	killer_immunoglobulin-like_receptor	31,66	KIR2DL1	68,75	killer immunoglobulin-like receptor	KIR2DL1	3805	3802	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of inhibitory-motif killer_immunoglobulin-like_receptor , KIR2DL1 , is increased in natural killer cells from women with pelvic_endometriosis .
17060849	0	killer_immunoglobulin-like_receptors	31,67	KIR	69,72	killer immunoglobulin-like receptors	KIR	3805	3805	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Low number of donor activating killer_immunoglobulin-like_receptors -LRB- KIR -RRB- genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem_cell_transplantation .
11821086	0	killer_inhibitory_receptor	10,36	KIR2DL1	37,44	killer inhibitory receptor	KIR2DL1	3805	3802	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Increased killer_inhibitory_receptor KIR2DL1 expression among natural killer cells in women with pelvic_endometriosis .
10669749	0	kinase-associated_phosphatase	18,47	KAP	49,52	kinase-associated phosphatase	KAP	1033	1033	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of kinase-associated_phosphatase -LRB- KAP -RRB- in breast_and_prostate_cancer and inhibition of the transformed phenotype by antisense KAP expression .
17984092	0	kinase-interacting_stathmin	52,79	FoxM1	0,5	kinase-interacting stathmin	FoxM1	127933	2305	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FoxM1 regulates growth factor-induced expression of kinase-interacting_stathmin -LRB- KIS -RRB- to promote cell cycle progression .
11964068	0	kinase-related_protein	19,41	telokin	43,50	kinase-related protein	telokin	4638	4638	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of kinase-related_protein -LRB- telokin -RRB- in tonic and phasic smooth muscles .
20936698	0	kinase_D-interacting_substrate_of_220_kDa	108,149	ankyrin_repeat-rich_membrane_spanning	70,107	kinase D-interacting substrate of 220 kDa	ankyrin repeat-rich membrane spanning	57498	57498	Gene	Gene	Regulation|parataxis|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of inhibitory neurotransmission by the scaffolding protein ankyrin_repeat-rich_membrane_spanning / kinase_D-interacting_substrate_of_220_kDa .
23158831	0	kinase_insert_domain-containing_receptor	15,55	KDR	57,60	kinase insert domain-containing receptor	KDR	3791	3791	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of kinase_insert_domain-containing_receptor -LRB- KDR -RRB- gene polymorphisms with idiopathic recurrent_spontaneous_abortion in Korean women .
11742867	0	kinase_insert_domain-containing_receptor	143,183	vascular_endothelial_cell_growth_factor	89,128	kinase insert domain-containing receptor	vascular endothelial cell growth factor	3791	7422	Gene	Gene	receptor-2|appos|START_ENTITY receptor-2|compound|END_ENTITY	Vascular_endothelial_cell_growth_factor-driven endothelial tube formation is mediated by vascular_endothelial_cell_growth_factor receptor-2 , a kinase_insert_domain-containing_receptor .
21695506	0	kinase_insert_domain_receptor	117,146	KDR	148,151	kinase insert domain receptor	KDR	3791	3791	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Molecular docking and 3D-QSAR study on 4 - -LRB- 1H-indazol-4-yl -RRB- phenylamino and aminopyrazolopyridine_urea derivatives as kinase_insert_domain_receptor -LRB- KDR -RRB- inhibitors .
23393131	0	kinase_insert_domain_receptor	116,145	KDR	147,150	kinase insert domain receptor	KDR	3791	3791	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
26634469	0	kinase_insert_domain_receptor	11,40	KDR	42,45	kinase insert domain receptor	KDR	3791	3791	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of kinase_insert_domain_receptor -LRB- KDR -RRB- gene silencing on the sensitivity of A549 cells to erlotinib .
16926250	0	kinase_insert_domain_receptor	120,149	vascular_endothelial_growth_factor	85,119	kinase insert domain receptor	vascular endothelial growth factor	3791	7422	Gene	Gene	START_ENTITY|dep|stimulates stimulates|dobj|proliferation proliferation|nmod|END_ENTITY	Pituitary_tumor_transforming_gene -LRB- PTTG -RRB- stimulates thyroid cell proliferation via a vascular_endothelial_growth_factor / kinase_insert_domain_receptor / inhibitor of DNA binding-3 autocrine pathway .
23393131	0	kinase_insert_domain_receptor	116,145	vascular_endothelial_growth_factor	63,97	kinase insert domain receptor	vascular endothelial growth factor	3791	7422	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
21590706	0	kindlin-2	32,41	Rac1	13,17	kindlin-2	Rac1	218952(Tax:10090)	19353(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Mediation of Rac1 activation by kindlin-2 : an essential function in osteoblast adhesion , spreading , and proliferation .
23394833	0	kinesin-1	70,79	ensconsin	32,41	kinesin-1	ensconsin	39445(Tax:7227)	38491(Tax:7227)	Gene	Gene	cofactor|nmod|START_ENTITY cofactor|nsubj|END_ENTITY	The microtubule-binding protein ensconsin is an essential cofactor of kinesin-1 .
16298999	0	kinesin-2	12,21	KIF3	38,42	kinesin-2	KIF3	16563(Tax:10090)	16568(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Role of the kinesin-2 family protein , KIF3 , during mitosis .
7822426	0	kinesin-related_protein	88,111	mitotic_centromere-associated_kinesin	47,84	kinesin-related protein	mitotic centromere-associated kinesin	67946(Tax:10090)	73804(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Identification and partial characterization of mitotic_centromere-associated_kinesin , a kinesin-related_protein that associates with centromeres during mitosis .
23300462	0	kinesin_family_member_1C	92,116	Orch3	18,23	kinesin family member 1C	Orch3	16562(Tax:10090)	112260(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of Orch3 , a locus controlling dominant resistance to autoimmune_orchitis , as kinesin_family_member_1C .
24426772	0	kinesin_family_member_21A	31,56	KIF21A	58,64	kinesin family member 21A	KIF21A	55605	55605	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Maternal germline mosaicism of kinesin_family_member_21A -LRB- KIF21A -RRB- mutation causes complex phenotypes in a Chinese family with congenital fibrosis of the extraocular muscles .
15987681	0	kinesin_light_chain_1	20,41	JLP	0,3	kinesin light chain 1	JLP	3831	9043	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	JLP associates with kinesin_light_chain_1 through a novel leucine zipper-like domain .
12839500	0	kinesin_light_chain_1	44,65	KNS2	67,71	kinesin light chain 1	KNS2	3831	3831	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternatively spliced products of the human kinesin_light_chain_1 -LRB- KNS2 -RRB- gene .
18423496	0	kinesin_superfamily7	40,60	kif7	62,66	kinesin superfamily7	kif7	101158754	101158754	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cloning and developmental expression of kinesin_superfamily7 -LRB- kif7 -RRB- in the brackish medaka -LRB- Oryzias melastigma -RRB- , a close relative of the Japanese_medaka -LRB- Oryzias_latipes -RRB- .
12809554	0	kinesin_superfamily_protein_member_4	21,57	BRCA2-associated_factor_35	63,89	kinesin superfamily protein member 4	BRCA2-associated factor 35	24137	10362	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human kinesin_superfamily_protein_member_4 with BRCA2-associated_factor_35 .
16822558	0	kinin_B1_receptor	14,31	angiotensin_II	57,71	kinin B1 receptor	angiotensin II	81509(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression Modulation|nmod|END_ENTITY	Modulation of kinin_B1_receptor expression by endogenous angiotensin_II in hypertensive rats .
3041137	0	kininase_I	20,30	Carboxypeptidase_N	0,18	kininase I	Carboxypeptidase N	1369	1369	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Carboxypeptidase_N -LRB- kininase_I -RRB- activity in blood and synovial fluid from patients with arthritis .
3038783	0	kininase_II	12,23	Kininase_I	0,10	kininase II	Kininase I	1636	1369	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|appos|levels	Kininase_I , kininase_II and aminopeptidase levels in patients with gastrointestinal_tumors .
3027766	0	kininase_II	81,92	angiotensin-converting_enzyme	41,70	kininase II	angiotensin-converting enzyme	24310(Tax:10116)	24310(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Compensatory increase in adrenomedullary angiotensin-converting_enzyme activity -LRB- kininase_II -RRB- after unilateral adrenalectomy .
6308020	0	kininase_II	11,22	bradykinin	63,73	kininase II	bradykinin	1636	3827	Gene	Gene	Effects|nmod|START_ENTITY inhibitors|nsubj|Effects inhibitors|nmod|END_ENTITY	Effects of kininase_II inhibitors on the vasomotor response to bradykinin of feline intracranial and extracranial arteries in vitro and in situ .
6312406	0	kininase_II	14,25	bradykinin	84,94	kininase II	bradykinin	1636	3827	Gene	Gene	effect|nmod|START_ENTITY inhibitors|nsubj|effect inhibitors|nmod|END_ENTITY	The effect of kininase_II inhibitors on the response of feline cerebral arteries to bradykinin and angiotensin .
3818598	0	kininogen	82,91	K	74,75	kininogen	K	288001(Tax:10116)	288001(Tax:10116)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Differing utilization of homologous transcription initiation sites of rat K and T kininogen genes under inflammation condition .
1733668	0	kininogen	29,38	KNG	45,48	kininogen	KNG	3827	3827	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal mapping of human kininogen gene -LRB- KNG -RRB- to 3q26 -- qter .
18000168	0	kininogen	19,28	mKng1	37,42	kininogen	mKng1	288001(Tax:10116)	16644(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion of murine kininogen gene 1 -LRB- mKng1 -RRB- causes loss of plasma kininogen and delays thrombosis .
18000168	0	kininogen	66,75	mKng1	37,42	kininogen	mKng1	288001(Tax:10116)	16644(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY causes|dobj|loss causes|nsubj|Deletion Deletion|nmod|gene gene|appos|END_ENTITY	Deletion of murine kininogen gene 1 -LRB- mKng1 -RRB- causes loss of plasma kininogen and delays thrombosis .
8898012	0	kininogen	27,36	tissue_kallikrein	55,72	kininogen	tissue kallikrein	288001(Tax:10116)	292855(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	High-salt diet upregulates kininogen and downregulates tissue_kallikrein expression in Dahl-SS and SHR rats .
21083881	0	kininogen-1	80,91	CD59	74,78	kininogen-1	CD59	3827	966	Gene	Gene	urine|nummod|START_ENTITY urine|nummod|END_ENTITY	Patients with ovarian_carcinoma excrete different altered levels of urine CD59 , kininogen-1 and fragments of inter-alpha-trypsin inhibitor heavy chain H4 and albumin .
23584484	0	kip1	106,110	BMP1	93,97	kip1	BMP1	1027	649	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	miR-194 suppresses metastasis of non-small cell lung_cancer through regulating expression of BMP1 and p27 -LRB- kip1 -RRB- .
11751512	0	kip1	61,65	Jab1	0,4	kip1	Jab1	1027	10987	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|amod|END_ENTITY	Jab1 expression is associated with inverse expression of p27 -LRB- kip1 -RRB- and poor prognosis in epithelial_ovarian_tumors .
16425184	0	kip1	33,37	Skp2	54,58	kip1	Skp2	1027	6502	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
18953829	0	kip1	55,59	Skp2	42,46	kip1	Skp2	1027	6502	Gene	Gene	variation|appos|START_ENTITY variation|nmod|END_ENTITY	-LSB- Expression variation and significance of Skp2 and p27 -LRB- kip1 -RRB- during the proliferation of Jurkat cells -RSB- .
26725384	0	kip1	130,134	bcl-2	116,121	kip1	bcl-2	1027	596	Gene	Gene	Proteins|appos|START_ENTITY Proteins|amod|END_ENTITY	Effects of Rapamycin and Rapamycin-loaded Poly -LRB- lactic-co-glycolic -RRB- Acid Nanoparticles on Apoptosis and Expression of bcl-2 and p27 -LRB- kip1 -RRB- Proteins of Human Umbilical Arterial Vascular Smooth Muscle Cell .
19556892	0	kip1	69,73	cofilin	24,31	kip1	cofilin	1027	1072	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Regulated expression of cofilin and the consequent regulation of p27 -LRB- kip1 -RRB- are essential for G -LRB- 1 -RRB- phase progression .
10644940	0	kip1	31,35	p27	27,30	kip1	p27	1027	3429	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of p27 -LRB- kip1 -RRB- protein expression and spontaneous apoptosis in patients with colorectal_adenocarcinomas .
10766421	0	kip1	19,23	p27	15,18	kip1	p27	1027	10671	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p27 -LRB- kip1 -RRB- in ceramide-mediated apoptosis in HL-60 cells .
10837916	0	kip1	27,31	p27	23,26	kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and role of p27 -LRB- kip1 -RRB- in neuronal differentiation of embryonal_carcinoma cells .
10861499	0	kip1	4,8	p27	0,3	kip1	p27	1027	3429	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p27 -LRB- kip1 -RRB- expression in breast_carcinomas : an immunohistochemical study on 512 patients with long-term follow-up .
10864486	0	kip1	4,8	p27	0,3	kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p27 -LRB- kip1 -RRB- expression in rectal_cancer correlates with disease-free survival .
11420693	0	kip1	78,82	p27	74,77	kip1	p27	1027	10671	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27 -LRB- kip1 -RRB- levels .
11536304	0	kip1	43,47	p27	39,42	kip1	p27	1027	3429	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Methylation and mutational analysis of p27 -LRB- kip1 -RRB- in prostate_carcinoma .
11804875	0	kip1	138,142	p27	134,137	kip1	p27	1027	3429	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Interferon-gamma inhibits hepatocyte_growth_factor-stimulated cell proliferation of human bronchial epithelial cells : upregulation of p27 -LRB- kip1 -RRB- cyclin-dependent kinase inhibitor .
11967155	0	kip1	34,38	p27	30,33	kip1	p27	1027	3429	Gene	Gene	degradation|appos|START_ENTITY degradation|amod|END_ENTITY	The COP9 signalosome inhibits p27 -LRB- kip1 -RRB- degradation and impedes G1-S phase progression via deneddylation of SCF Cul1 .
11969263	0	kip1	102,106	p27	98,101	kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Deregulated expression of the homeobox gene Cux-1 in transgenic_mice results in downregulation of p27 -LRB- kip1 -RRB- expression during nephrogenesis , glomerular_abnormalities , and multiorgan hyperplasia .
15542603	3	kip1	501,505	p27	497,500	kip1	p27	1027	10671	Gene	Gene	shows|appos|START_ENTITY shows|amod|END_ENTITY	Here we show that p27 -LRB- kip1 -RRB- is not regulated by transcriptional control but that p27 -LRB- kip1 -RRB- protein shows increased stability after inhibition of the phosphoinositide -LRB- PI -RRB- 3-kinase pathway .
15654821	0	kip1	82,86	p27	78,81	kip1	p27	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Mycophenolate_mofetil and roscovitine decrease cyclin expression and increase p27 -LRB- kip1 -RRB- expression in anti Thy1 mesangial proliferative nephritis .
15930262	0	kip1	37,41	p27	33,36	kip1	p27	1027	3429	Gene	Gene	stability|appos|START_ENTITY stability|amod|END_ENTITY	Tumor suppressor VDUP1 increases p27 -LRB- kip1 -RRB- stability by inhibiting JAB1 .
16022660	0	kip1	4,8	p27	0,3	kip1	p27	1027	10534	Gene	Gene	regulation|compound|START_ENTITY regulation|amod|END_ENTITY	p27 -LRB- kip1 -RRB- functional regulation in human cancer : a potential target for therapeutic designs .
16425184	0	kip1	132,136	p27	128,131	kip1	p27	1027	10671	Gene	Gene	regulation|appos|START_ENTITY regulation|amod|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
16425184	0	kip1	33,37	p27	29,32	kip1	p27	1027	10671	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
16740772	0	kip1	198,202	p27	194,197	kip1	p27	1027	10671	Gene	Gene	enhancement|compound|START_ENTITY enhancement|amod|END_ENTITY	Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal_clear_cell_carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation , cyclin-dependent_kinase_2 reduction , p27 -LRB- kip1 -RRB- enhancement , and disruption of binding to the extracellular matrix .
17031475	0	kip1	86,90	p27	82,85	kip1	p27	1027	10534	Gene	Gene	translocation|appos|START_ENTITY translocation|amod|END_ENTITY	Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27 -LRB- kip1 -RRB- translocation and retinoblastoma protein phosphorylation by 1 ' - acetoxychavicol_acetate .
17237771	0	kip1	51,55	p27	47,50	kip1	p27	1027	10534	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	The energy sensing LKB1-AMPK pathway regulates p27 -LRB- kip1 -RRB- phosphorylation mediating the decision to enter autophagy or apoptosis .
17448572	0	kip1	67,71	p27	63,66	kip1	p27	1027	10671	Gene	Gene	degradation|appos|START_ENTITY degradation|nmod|END_ENTITY	Enhanced proteasome-dependent degradation of the CDK inhibitor p27 -LRB- kip1 -RRB- in immortalized lymphocytes from Alzheimer 's _ dementia patients .
18089324	0	kip1	33,37	p27	29,32	kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	A clinicopathologic study of p27 -LRB- kip1 -RRB- expression in renal allograft biopsy .
18598941	0	kip1	71,75	p27	67,70	kip1	p27	1027	10534	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Argyrin_a reveals a critical role for the tumor suppressor protein p27 -LRB- kip1 -RRB- in mediating antitumor activities in response to proteasome inhibition .
19273599	0	kip1	52,56	p27	48,51	kip1	p27	1027	3429	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	miR-181a regulates cap-dependent translation of p27 -LRB- kip1 -RRB- mRNA in myeloid cells .
19888978	0	kip1	23,27	p27	19,22	kip1	p27	1027	10671	Gene	Gene	EZH2|appos|START_ENTITY EZH2|appos|END_ENTITY	The value of EZH2 , p27 -LRB- kip1 -RRB- , BMI-1 and MIB-1 on biopsy specimens with low-risk prostate_cancer in selecting men with significant prostate_cancer at prostatectomy .
20193371	0	kip1	44,48	p27	40,43	kip1	p27	1027	10534	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Effects of transfected pIRES-p21 -LRB- waf1 -RRB- - p27 -LRB- kip1 -RRB- gene on the duplication of centrosomes and the proliferation of breast_cancer cell line MCF-7 -RSB- .
20923380	0	kip1	29,33	p27	25,28	kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The relationship between p27 -LRB- kip1 -RRB- expression and the change of radiosensitivity of esophageal_carcinoma cells .
21734459	0	kip1	24,28	p27	20,23	kip1	p27	1027	10671	Gene	Gene	stability|appos|START_ENTITY stability|amod|END_ENTITY	Siah1/SIP regulates p27 -LRB- kip1 -RRB- stability and cell migration under metabolic stress .
22895010	0	kip1	17,21	p27	13,16	kip1	p27	1027	10534	Gene	Gene	light|appos|START_ENTITY light|nmod|END_ENTITY	New light on p27 -LRB- kip1 -RRB- in breast_cancer .
25015295	0	kip1	53,57	p27	49,52	kip1	p27	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Rho/ROCK pathway inhibition by the CDK inhibitor p27 -LRB- kip1 -RRB- participates in the onset of macrophage 3D-mesenchymal migration .
25323759	0	kip1	38,42	p27	34,37	kip1	p27	1027	10534	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of p27 -LRB- kip1 -RRB- in metastatic laryngeal_squamous_cell_carcinoma .
25536625	0	kip1	74,78	p27	70,73	kip1	p27	1027	3429	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Immunohistochemical expression of p53 , p63 , c-myc , p21 -LRB- WAF1/cip1 -RRB- and p27 -LRB- kip1 -RRB- proteins in urothelial_bladder_carcinoma : correlation with clinicopathological parameters .
26788203	0	kip1	27,31	p27	23,26	kip1	p27	1027	10534	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Expression of Skp2 and p27 -LRB- kip1 -RRB- proteins in hypopharyngeal_squamous_cell_carcinoma and its clinical significance .
9177226	0	kip1	134,138	p27	25,28	kip1	p27	1027	3429	Gene	Gene	p27|appos|START_ENTITY expression|nmod|p27 correlation|nmod|expression expression|dep|correlation expression|nmod|kip1 kip1|amod|END_ENTITY	High level expression of p27 -LRB- kip1 -RRB- and cyclin_D1 in some human breast_cancer cells : inverse correlation between the expression of p27 -LRB- kip1 -RRB- and degree of malignancy_in_human_breast_and_colorectal_cancers .
9177226	0	kip1	29,33	p27	130,133	kip1	p27	1027	3429	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|nmod|END_ENTITY	High level expression of p27 -LRB- kip1 -RRB- and cyclin_D1 in some human breast_cancer cells : inverse correlation between the expression of p27 -LRB- kip1 -RRB- and degree of malignancy_in_human_breast_and_colorectal_cancers .
9784625	0	kip1	63,67	p27	59,62	kip1	p27	1027	3429	Gene	Gene	depletion|appos|START_ENTITY depletion|amod|END_ENTITY	cAMP inhibits linoleic_acid-induced growth by antagonizing p27 -LRB- kip1 -RRB- depletion , but not interfering with the extracellular signal-regulated kinase or AP-1 activities .
10772955	0	kip1	103,107	skp2	86,90	kip1	skp2	1027	6502	Gene	Gene	p27|appos|START_ENTITY SCF|nmod|p27 SCF|appos|END_ENTITY	Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF -LRB- skp2 -RRB- toward p27 -LRB- kip1 -RRB- .
26988311	0	kip2	54,58	Cdkn1c	61,67	kip2	Cdkn1c	12577(Tax:10090)	12577(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	The developmental expression of the CDK inhibitor p57 -LRB- kip2 -RRB- -LRB- Cdkn1c -RRB- in the early mouse placenta .
16618659	0	kip2	4,8	p57	0,3	kip2	p57	1028	1028	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	p57 -LRB- kip2 -RRB- expression is related to carcinogenesis and tumor progression in laryngeal tissues .
25807810	0	kip2	19,23	p57	15,18	kip2	p57	1028	1028	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- Expression of p57 -LRB- kip2 -RRB- gene in placenta tissue of patients with pre-eclampsia -RSB- .
26988311	0	kip2	54,58	p57	50,53	kip2	p57	12577(Tax:10090)	12721(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The developmental expression of the CDK inhibitor p57 -LRB- kip2 -RRB- -LRB- Cdkn1c -RRB- in the early mouse placenta .
21755670	0	kisspeptin	12,22	GnIH	60,64	kisspeptin	GnIH	101107719	100127217(Tax:9940)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of kisspeptin and gonadotropin_inhibitory_hormone -LRB- GnIH -RRB- in the seasonality of reproduction in sheep .
25375207	0	kisspeptin	70,80	KiSS-1	82,88	kisspeptin	KiSS-1	101107719	101107719	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Influences of melatonin treatment , melatonin_receptor_1A -LRB- MTNR1A -RRB- and kisspeptin -LRB- KiSS-1 -RRB- gene polymorphisms on first conception in Sarda ewe lambs .
25269483	0	kisspeptin	63,73	Kisspeptin	0,10	kisspeptin	Kisspeptin	280287(Tax:10090)	280287(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|signaling signaling|compound|END_ENTITY	Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility .
23504956	0	kisspeptin	61,71	LRH-1	17,22	kisspeptin	LRH-1	280287(Tax:10090)	26424(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus .
25269483	0	kisspeptin	63,73	PI3K	25,29	kisspeptin	PI3K	280287(Tax:10090)	18708(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|signaling signaling|compound|END_ENTITY	Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility .
22343304	0	kisspeptin	69,79	gonadotropin-releasing_hormone	26,56	kisspeptin	gonadotropin-releasing hormone	101107719	443529(Tax:9940)	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Seasonal variation in the gonadotropin-releasing_hormone response to kisspeptin in sheep : possible kisspeptin regulation of the kisspeptin receptor .
1379243	0	kit	35,38	stem_cell_factor	90,106	kit	stem cell factor	3815	4254	Gene	Gene	receptor|compound|START_ENTITY Dimerization|nmod|receptor Dimerization|nmod|END_ENTITY	Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem_cell_factor .
12062105	0	kit-ligand	103,113	MMP-9	77,82	kit-ligand	MMP-9	17311(Tax:10090)	17395(Tax:10090)	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand .
7685343	1	kit_ligand	213,223	GTP_cyclohydrolase_I	145,165	kit ligand	GTP cyclohydrolase I	17311(Tax:10090)	14528(Tax:10090)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of GTP_cyclohydrolase_I and tryptophan 5-monooxygenase activity by the kit_ligand .
10820228	0	kit_ligand	103,113	IL-1	133,137	kit ligand	IL-1	17311(Tax:10090)	111343(Tax:10090)	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Murine bone marrow-derived mast cells as potent producers of IL-9 : costimulatory function of IL-10 and kit_ligand in the presence of IL-1 .
10228034	0	kit_ligand	60,70	gelatinases_A_and_B	24,43	kit ligand	gelatinases A and B	403507(Tax:9615)	403885(Tax:9615)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Mast cell expression of gelatinases_A_and_B is regulated by kit_ligand and TGF-beta .
10819761	0	kit_ligand	25,35	stem_cell_factor	36,52	kit ligand	stem cell factor	4254	4254	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression and action of kit_ligand / stem_cell_factor in normal human and bovine ovarian_surface_epithelium and ovarian_cancer .
22085651	0	klk1b26	33,40	kallikrein_1b26	16,31	klk1b26	kallikrein 1b26	13647(Tax:10090)	13647(Tax:10090)	Gene	Gene	translation|appos|START_ENTITY translation|amod|END_ENTITY	Interference of kallikrein_1b26 -LRB- klk1b26 -RRB- translation by microRNA specifically expressed in female mouse submandibular glands : an additional mechanism for sexual dimorphism of klk1b26 protein in the glands .
25402964	0	klotho	28,34	Fibroblast_growth_factor_23	0,27	klotho	Fibroblast growth factor 23	9365	8074	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Fibroblast_growth_factor_23 / klotho axis in chronic_kidney_disease .
16239475	0	klotho	23,29	TRPV5	59,64	klotho	TRPV5	9365	56302	Gene	Gene	hydrolyzes|nsubj|START_ENTITY hydrolyzes|dobj|channel channel|compound|END_ENTITY	The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel .
23970553	0	klotho	68,74	TRPV5	31,36	klotho	TRPV5	9365	56302	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The epithelial calcium channel TRPV5 is regulated differentially by klotho and sialidase .
16436388	0	klotho	55,61	fibroblast_growth_factor-23	14,41	klotho	fibroblast growth factor-23	16591(Tax:10090)	64654(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of fibroblast_growth_factor-23 signaling by klotho .
19765400	0	krox-20	7,14	c-Jun	0,5	krox-20	c-Jun	1959	3725	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	c-Jun , krox-20 , and integrin_beta4 expression following chronic_nerve_compression injury .
8625972	0	krox_20	147,154	egr-2	141,146	krox 20	egr-2	1959	1959	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	B cell early response gene expression coupled to B cell receptor , CD40 and interleukin-4_receptor co-stimulation : evidence for a role of the egr-2 / krox_20 transcription factor in B cell proliferation .
20977429	0	kynurenine_aminotransferase-IV	114,144	mitochondrial_aspartate_aminotransferase	53,93	kynurenine aminotransferase-IV	mitochondrial aspartate aminotransferase	14719(Tax:10090)	14719(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biochemical and structural characterization of mouse mitochondrial_aspartate_aminotransferase , a newly identified kynurenine_aminotransferase-IV .
24952951	0	kynurenine_aminotransferase-IV	114,144	mitochondrial_aspartate_aminotransferase	53,93	kynurenine aminotransferase-IV	mitochondrial aspartate aminotransferase	14719(Tax:10090)	14719(Tax:10090)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Biochemical and structural characterization of mouse mitochondrial_aspartate_aminotransferase , a newly identified kynurenine_aminotransferase-IV .
24647121	0	kynurenine_aminotransferase_II	25,55	KAT_II	57,63	kynurenine aminotransferase II	KAT II	29416(Tax:10116)	29416(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	A systemically-available kynurenine_aminotransferase_II -LRB- KAT_II -RRB- inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats .
15505044	0	lacrimal_gland_protein	66,88	PKCalpha	50,58	lacrimal gland protein	PKCalpha	292801(Tax:10116)	24680(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of overexpression of constitutively active PKCalpha on rat lacrimal_gland_protein secretion .
21841820	0	lactadherin	7,18	D1/D3	37,42	lactadherin	D1/D3	17304(Tax:10090)	13370;77337	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	MFG-E8 / lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells .
17638889	0	lactadherin	7,18	MFG-E8	0,6	lactadherin	MFG-E8	17304(Tax:10090)	17304(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	MFG-E8 / lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis .
21841820	0	lactadherin	7,18	MFG-E8	0,6	lactadherin	MFG-E8	17304(Tax:10090)	17304(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	MFG-E8 / lactadherin regulates cyclins D1/D3 expression and enhances the tumorigenic potential of mammary epithelial cells .
18008006	0	lactadherin	30,41	Milk_fat_globule-EGF_factor_8	0,29	lactadherin	Milk fat globule-EGF factor 8	17304(Tax:10090)	17304(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY END_ENTITY|parataxis|plays	Milk_fat_globule-EGF_factor_8 / lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium .
10611160	0	lactase	39,46	Cdx2	24,28	lactase	Cdx2	3938	1045	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The homeodomain protein Cdx2 regulates lactase gene promoter activity during enterocyte differentiation .
18454942	0	lactase	27,34	GALT	99,103	lactase	GALT	3938	2592	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Synergistic effect of high lactase activity genotype and galactose-1-phosphate_uridyl_transferase -LRB- GALT -RRB- mutations on idiopathic presenile cataract formation .
16400612	0	lactase	42,49	LCT	56,59	lactase	LCT	3938	3938	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the translated region of the lactase gene -LRB- LCT -RRB- underlie congenital_lactase_deficiency .
19161632	0	lactase	28,35	LCT	42,45	lactase	LCT	3938	3938	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Four novel mutations in the lactase gene -LRB- LCT -RRB- underlying congenital_lactase_deficiency -LRB- CLD -RRB- .
26215149	0	lactase	28,35	LCT	42,45	lactase	LCT	3938	3938	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation within the lactase gene -LRB- LCT -RRB- : the first report of congenital_lactase_deficiency diagnosed in Central Europe .
10692580	0	lactase	66,73	lactase_phlorizin_hydrolase	82,109	lactase	lactase phlorizin hydrolase	3938	3938	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Dietary flavonoid and isoflavone_glycosides are hydrolysed by the lactase site of lactase_phlorizin_hydrolase .
15178553	0	lactase-phlorizin_hydrolase	26,53	GATA-4	66,72	lactase-phlorizin hydrolase	GATA-4	226413(Tax:10090)	14463(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Complex regulation of the lactase-phlorizin_hydrolase promoter by GATA-4 .
17934640	0	lactase-phlorizin_hydrolase	88,115	LCT	117,120	lactase-phlorizin hydrolase	LCT	3938	3938	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Correlation between lactose absorption and the C/T -13910 and G/A -22018 mutations of the lactase-phlorizin_hydrolase -LRB- LCT -RRB- gene in adult-type hypolactasia .
10692580	0	lactase_phlorizin_hydrolase	82,109	lactase	66,73	lactase phlorizin hydrolase	lactase	3938	3938	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Dietary flavonoid and isoflavone_glycosides are hydrolysed by the lactase site of lactase_phlorizin_hydrolase .
12441634	0	lactate_dehydrogenase	21,42	LDH-A	44,49	lactate dehydrogenase	LDH-A	102094829	102094829	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	PCR-RFLPs within the lactate_dehydrogenase -LRB- LDH-A -RRB- gene of the domestic_pigeon -LRB- Columba_livia var .
9828188	0	lactate_dehydrogenase_A	30,53	Interleukin_1alpha	0,18	lactate dehydrogenase A	Interleukin 1alpha	3939	3552	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin_1alpha stimulates lactate_dehydrogenase_A expression and lactate production in cultured porcine sertoli cells .
10385397	0	lactate_dehydrogenase_A	39,62	Tumor_necrosis_factor-alpha	0,27	lactate dehydrogenase A	Tumor necrosis factor-alpha	3939	7124	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha stimulates lactate_dehydrogenase_A expression in porcine cultured sertoli cells : mechanisms of action .
11058554	0	lactate_dehydrogenase_A	77,100	tumor_necrosis_factor_alpha	27,54	lactate dehydrogenase A	tumor necrosis factor alpha	3939	7124	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression effect|compound|END_ENTITY	Role of sphingosine in the tumor_necrosis_factor_alpha stimulatory effect on lactate_dehydrogenase_A expression and activity in porcine Sertoli cells .
8445652	0	lactate_dehydrogenase_B	5,28	epsilon-crystallin	29,47	lactate dehydrogenase B	epsilon-crystallin	101801152	101801152	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	Duck lactate_dehydrogenase_B / epsilon-crystallin gene .
18930904	0	lactate_dehydrogenase_c	13,36	Ldhc	38,42	lactate dehydrogenase c	Ldhc	3948	3948	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Homo_sapiens lactate_dehydrogenase_c -LRB- Ldhc -RRB- gene expression in cancer cells is regulated by transcription factor Sp1 , CREB , and CpG island methylation .
18930904	0	lactate_dehydrogenase_c	13,36	Sp1	113,116	lactate dehydrogenase c	Sp1	3948	6667	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Homo_sapiens lactate_dehydrogenase_c -LRB- Ldhc -RRB- gene expression in cancer cells is regulated by transcription factor Sp1 , CREB , and CpG island methylation .
15216955	0	lactoferrin	11,22	IL-6	26,30	lactoferrin	IL-6	17002(Tax:10090)	16193(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|production production|compound|END_ENTITY	Effects of lactoferrin on IL-6 production by peritoneal and alveolar cells in cyclophosphamide-treated mice .
7949732	0	lactoferrin	11,22	LTF	29,32	lactoferrin	LTF	280846(Tax:9913)	280846(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The bovine lactoferrin gene -LRB- LTF -RRB- maps to chromosome 22 and syntenic group U12 .
21404021	0	lactoferrin	12,23	VEGF	68,72	lactoferrin	VEGF	17002(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|nmod|END_ENTITY	Bovine milk lactoferrin induces synthesis of the angiogenic factors VEGF and FGF2 in osteoblasts via the p44/p42 MAP kinase pathway .
8776733	0	lactoferrin	38,49	epidermal_growth_factor	58,81	lactoferrin	epidermal growth factor	17002(Tax:10090)	13645(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Promoter-specific activation of mouse lactoferrin gene by epidermal_growth_factor involves two adjacent regulatory elements .
21688123	0	lactoferrin	7,18	interleukin-11	27,41	lactoferrin	interleukin-11	17002(Tax:10090)	16156(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|production production|amod|END_ENTITY	Bovine lactoferrin induces interleukin-11 production in a hepatitis_mouse model and human intestinal myofibroblasts .
8901116	0	lactoferrin	11,22	interleukin_8	59,72	lactoferrin	interleukin 8	280846(Tax:9913)	3576	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|nmod|END_ENTITY	Effects of lactoferrin and lactoferricin on the release of interleukin_8 from human polymorphonuclear leukocytes .
14765739	0	lactoferrin	24,35	lactoferrin	45,56	lactoferrin	lactoferrin	280846(Tax:9913)	280846(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of supplemental lactoferrin on serum lactoferrin and IgG concentrations and neutrophil oxidative metabolism in Holstein calves .
14765739	0	lactoferrin	45,56	lactoferrin	24,35	lactoferrin	lactoferrin	280846(Tax:9913)	280846(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of supplemental lactoferrin on serum lactoferrin and IgG concentrations and neutrophil oxidative metabolism in Holstein calves .
16529153	0	lactoferrin	105,116	lactoferrin	33,44	lactoferrin	lactoferrin	397649(Tax:9823)	397649(Tax:9823)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Developmental gene expression of lactoferrin in duodenum and effect of weaning age on gene expression of lactoferrin in piglets .
16529153	0	lactoferrin	33,44	lactoferrin	105,116	lactoferrin	lactoferrin	397649(Tax:9823)	397649(Tax:9823)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Developmental gene expression of lactoferrin in duodenum and effect of weaning age on gene expression of lactoferrin in piglets .
15178744	0	lactoferrin	83,94	low-density_lipoprotein_receptor-related_protein_1	4,54	lactoferrin	low-density lipoprotein receptor-related protein 1	301034(Tax:10116)	4035	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	The low-density_lipoprotein_receptor-related_protein_1 is a mitogenic receptor for lactoferrin in osteoblastic cells .
11292760	0	lactoferrin	37,48	pneumococcal_surface_protein_A	52,82	lactoferrin	pneumococcal surface protein A	280846(Tax:9913)	653509	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of binding of human lactoferrin to pneumococcal_surface_protein_A .
1683650	0	lactotransferrin	30,46	CD4	65,68	lactotransferrin	CD4	17002(Tax:10090)	12504(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Immunostimulatory activity of lactotransferrin and maturation of CD4 - CD8 - murine thymocytes .
1683650	0	lactotransferrin	30,46	CD8	70,73	lactotransferrin	CD8	17002(Tax:10090)	925	Gene	Gene	activity|nmod|START_ENTITY activity|dep|END_ENTITY	Immunostimulatory activity of lactotransferrin and maturation of CD4 - CD8 - murine thymocytes .
23479198	0	lactotransferrin	44,60	miR-214	0,7	lactotransferrin	miR-214	17002(Tax:10090)	387210(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal_carcinoma .
3947646	0	lactoylglutathione_lyase	38,62	glyoxalase_I	24,36	lactoylglutathione lyase	glyoxalase I	2739	2739	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of mammalian glyoxalase_I -LRB- lactoylglutathione_lyase -RRB- by N-acylated_S-blocked_glutathione derivatives as a probe for the role of the N-site of glutathione in glyoxalase_I mechanism .
20820887	0	ladybird-like_homeobox_2	14,38	LBX2	40,44	ladybird-like homeobox 2	LBX2	16815(Tax:10090)	16815(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of ladybird-like_homeobox_2 -LRB- LBX2 -RRB- during ovarian development and folliculogenesis in the mouse .
23483278	0	lag-1	23,28	Notch	7,12	lag-1	Notch	177373(Tax:6239)	176282(Tax:6239)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	LIN-12 / Notch regulates lag-1 and lin-12 expression during anchor cell/ventral uterine precursor cell fate specification .
21552940	0	lak	23,26	Interleukin-4	0,13	lak	Interleukin-4	80216	3565	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits lak and initial phase til activity via interleukin-2 receptor .
11432740	0	lamin_A	55,62	SP3	0,3	lamin A	SP3	36615(Tax:7227)	31917(Tax:7227)	Gene	Gene	promoter|amod|START_ENTITY activation|nmod|promoter mediate|dobj|activation mediate|nsubj|END_ENTITY	SP3 and AP-1 mediate transcriptional activation of the lamin_A proximal promoter .
16648470	0	lamin_A	28,35	SUN1	0,4	lamin A	SUN1	4000	23353	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	SUN1 interacts with nuclear lamin_A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton .
27059139	0	lamin_B_receptor	25,41	LBR	43,46	lamin B receptor	LBR	3930	3930	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Aberrant localization of lamin_B_receptor -LRB- LBR -RRB- in cellular senescence in human cells .
16254246	0	lamin_Dm0	32,41	JIL-1_kinase	4,16	lamin Dm0	JIL-1 kinase	33782(Tax:7227)	39241(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The JIL-1_kinase interacts with lamin_Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells .
9403717	0	laminin-gamma1	77,91	LamC1	32,37	laminin-gamma1	LamC1	39118(Tax:7227)	3915	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Sp1-mediated transactivation of LamC1 promoter and coordinated expression of laminin-gamma1 and Sp1 in human hepatocellular_carcinomas .
2591971	0	laminin_A_chain	6,21	LAMA	23,27	laminin A chain	LAMA	284217	284217	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human laminin_A_chain -LRB- LAMA -RRB- gene : chromosomal mapping to locus 18p11 .3 .
3167041	0	laminin_B1	68,78	laminin_B2_chain	31,47	laminin B1	laminin B2 chain	16777(Tax:10090)	226519(Tax:10090)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Primary structure of the mouse laminin_B2_chain and comparison with laminin_B1 .
3167041	0	laminin_B2_chain	31,47	laminin_B1	68,78	laminin B2 chain	laminin B1	226519(Tax:10090)	16777(Tax:10090)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Primary structure of the mouse laminin_B2_chain and comparison with laminin_B1 .
7874173	0	laminin_alpha_2	54,69	Lama2	71,76	laminin alpha 2	Lama2	16773(Tax:10090)	16773(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Murine muscular_dystrophy caused by a mutation in the laminin_alpha_2 -LRB- Lama2 -RRB- gene .
22150225	0	laminin_alpha_4	22,37	MMP3	14,18	laminin alpha 4	MMP3	3910	4314	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of MMP3 by laminin_alpha_4 in human osteoarthritic cartilage .
20556798	0	laminin_beta2	23,36	LAMB2	38,43	laminin beta2	LAMB2	3913	3913	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the human laminin_beta2 -LRB- LAMB2 -RRB- gene and the associated phenotypic spectrum .
11597123	0	laminin_binding_protein_precursor	24,57	Midkine	0,7	laminin binding protein precursor	Midkine	16803(Tax:10090)	17242(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Midkine binds to 37-kDa laminin_binding_protein_precursor , leading to nuclear transport of the complex .
19193855	0	laminin_gamma1	55,69	netrin-4	45,53	laminin gamma1	netrin-4	226519(Tax:10090)	57764(Tax:10090)	Gene	Gene	chain|amod|START_ENTITY chain|amod|END_ENTITY	Discovery of a functional protein complex of netrin-4 , laminin_gamma1 chain , and integrin alpha6beta1 in mouse neural stem cells .
18202837	0	laminin_receptor	48,64	RPSA	71,75	laminin receptor	RPSA	100125628(Tax:9940)	100125628(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structural and functional analysis of the ovine laminin_receptor gene -LRB- RPSA -RRB- : Possible involvement of the LRP/LR protein in scrapie response .
9396609	0	laminin_receptor_precursor	17,43	prion_protein	63,76	laminin receptor precursor	prion protein	3921	5621	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The human 37-kDa laminin_receptor_precursor interacts with the prion_protein in eukaryotic cells .
15246873	0	laminin_receptor_precursor_protein	43,77	Doppel	15,21	laminin receptor precursor protein	Doppel	3921	23627	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Doppel with the full-length laminin_receptor_precursor_protein .
25551286	0	langerin	31,39	Caveolin-1	0,10	langerin	Caveolin-1	50489	857	Gene	Gene	uptake|nmod|START_ENTITY uptake|amod|END_ENTITY	Caveolin-1 mediated uptake via langerin restricts HIV-1_infection in human Langerhans cells .
12145339	0	lanosterol_14alpha-demethylase	87,117	CYP51	124,129	lanosterol 14alpha-demethylase	CYP51	1595	1595	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A cAMP-responsive element binding site is essential for sterol regulation of the human lanosterol_14alpha-demethylase gene -LRB- CYP51 -RRB- .
18466759	0	lanosterol_14alpha-demethylase	25,55	CYP51	57,62	lanosterol 14alpha-demethylase	CYP51	1595	1595	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of microsomal lanosterol_14alpha-demethylase -LRB- CYP51 -RRB- in an engineered soluble monomeric form .
8975714	0	lanosterol_14alpha-demethylase	35,65	CYP51	72,77	lanosterol 14alpha-demethylase	CYP51	1595	1595	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and mapping of the human lanosterol_14alpha-demethylase gene -LRB- CYP51 -RRB- encoding the cytochrome_P450 involved in cholesterol biosynthesis ; comparison of exon/intron organization with other mammalian and fungal CYP genes .
10551787	0	lanosterol_14alpha-demethylase	124,154	cAMP-responsive_element_modulator	43,76	lanosterol 14alpha-demethylase	cAMP-responsive element modulator	13121(Tax:10090)	12916(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Cyclic adenosine_3 ' ,5 ' - monophosphate -LRB- cAMP -RRB- / cAMP-responsive_element_modulator -LRB- CREM -RRB- - dependent regulation of cholesterogenic lanosterol_14alpha-demethylase -LRB- CYP51 -RRB- in spermatids .
19528316	0	lanthionine_synthetase_C-like_protein_1	19,58	Eps8	84,88	lanthionine synthetase C-like protein 1	Eps8	10314	2059	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of human lanthionine_synthetase_C-like_protein_1 and its interaction with Eps8 and glutathione .
10212829	0	lar	61,64	insulin_receptor	90,106	lar	insulin receptor	360406(Tax:10116)	24954(Tax:10116)	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Inhibition of the transmembrane protein tyrosine phosphatase lar by 3S-peptide-I enhances insulin_receptor phosphorylation in intact cells .
25119020	0	large_tumor_suppressor_1	29,53	LATS1	55,60	large tumor suppressor 1	LATS1	9113	9113	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Biallelic alterations of the large_tumor_suppressor_1 -LRB- LATS1 -RRB- gene in infiltrative , but not superficial , basal_cell_carcinomas in a Japanese patient with nevoid_basal_cell_carcinoma_syndrome .
15777619	0	large_tumor_suppressor_gene	17,44	Lats1	46,51	large tumor suppressor gene	Lats1	9113	9113	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Two forms of the large_tumor_suppressor_gene -LRB- Lats1 -RRB- protein expressed in the vertebrate retina .
26101704	0	large_tumor_suppressor_kinase_2	88,119	MicroRNA-135b	0,13	large tumor suppressor kinase 2	MicroRNA-135b	26524	442891	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-135b regulates apoptosis and chemoresistance in colorectal_cancer by targeting large_tumor_suppressor_kinase_2 .
17387579	0	late_cornified_envelope-like_proline-rich_1	63,106	LELP1	108,113	late cornified envelope-like proline-rich 1	LELP1	149018	149018	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a chromosome 1q21 locus in close proximity to a late_cornified_envelope-like_proline-rich_1 -LRB- LELP1 -RRB- gene with total serum IgE levels .
12594277	0	latency-associated_peptide	31,57	CD4	0,3	latency-associated peptide	CD4	219103(Tax:10090)	12504(Tax:10090)	Gene	Gene	suppress|nsubj|START_ENTITY express|ccomp|suppress cells|acl:relcl|express CD25|dep|cells CD25|compound|END_ENTITY	CD4 + CD25 - T cells that express latency-associated_peptide on the surface suppress CD4 + CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism .
12594277	0	latency-associated_peptide	31,57	CD4	82,85	latency-associated peptide	CD4	219103(Tax:10090)	12504(Tax:10090)	Gene	Gene	suppress|nsubj|START_ENTITY suppress|dobj|colitis colitis|nummod|END_ENTITY	CD4 + CD25 - T cells that express latency-associated_peptide on the surface suppress CD4 + CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism .
21426338	0	latency-associated_peptide	13,39	CD4	88,91	latency-associated peptide	CD4	7040	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Induction of latency-associated_peptide -LRB- transforming_growth_factor-b -LRB- 1 -RRB- -RRB- expression on CD4 + T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-a production in a transforming growth factor-b-dependent manner .
19299332	0	latency-associated_peptide	24,50	FOXP3	120,125	latency-associated peptide	FOXP3	7040	50943	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Selective expression of latency-associated_peptide -LRB- LAP -RRB- and IL-1 receptor type I/II -LRB- CD121a/CD121b -RRB- on activated human FOXP3 + regulatory T cells allows for their purification from expansion cultures .
25669657	0	latent_TGF-beta_binding_protein_3	17,50	LTBP3	52,57	latent TGF-beta binding protein 3	LTBP3	16998(Tax:10090)	16998(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the latent_TGF-beta_binding_protein_3 -LRB- LTBP3 -RRB- gene cause brachyolmia with amelogenesis_imperfecta .
14576817	0	latent_infection_membrane_protein_1	27,62	p52	110,113	latent infection membrane protein 1	p52	9260	4791	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Epstein-Barr_virus-encoded latent_infection_membrane_protein_1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway .
1321789	0	latent_membrane_protein	26,49	CD23	76,80	latent membrane protein	CD23	9260	2208	Gene	Gene	expression|nmod|START_ENTITY independent|nsubj|expression independent|nmod|END_ENTITY	The expression of the EBV latent_membrane_protein -LRB- LMP-1 -RRB- is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin 's _ disease .
1321789	0	latent_membrane_protein	26,49	LMP-1	51,56	latent membrane protein	LMP-1	9260	9260	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of the EBV latent_membrane_protein -LRB- LMP-1 -RRB- is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin 's _ disease .
11781710	0	latent_membrane_protein-1	19,44	CD25	55,59	latent membrane protein-1	CD25	9260	3559	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|nummod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein-1 activates CD25 expression in lymphoma cells involving the NFkappaB pathway .
15555331	0	latent_membrane_protein_1	18,43	Ets-1	88,93	latent membrane protein 1	Ets-1	9260	2113	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- EB virus encoded latent_membrane_protein_1 mediated expression of transcription factor Ets-1 in nasopharyngeal_carcinoma cells -RSB- .
14673102	0	latent_membrane_protein_1	19,44	IRAK1	77,82	latent membrane protein 1	IRAK1	9260	3654	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 activation of NF-kappaB through IRAK1 and TRAF6 .
12673717	0	latent_membrane_protein_1	55,80	LMP-1	82,87	latent membrane protein 1	LMP-1	9260	9260	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Screening nasopharyngeal_carcinoma by detection of the latent_membrane_protein_1 -LRB- LMP-1 -RRB- gene with nasopharyngeal swabs .
18087217	0	latent_membrane_protein_1	113,138	LMP1	140,144	latent membrane protein 1	LMP1	9260	9260	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Expression of immune-related molecules in primary EBV-positive Chinese nasopharyngeal_carcinoma : associated with latent_membrane_protein_1 -LRB- LMP1 -RRB- expression .
18851787	0	latent_membrane_protein_1	43,68	LMP1	70,74	latent membrane protein 1	LMP1	9260	9260	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	-LSB- Correlation of Epstein-Barr_virus-encoded latent_membrane_protein_1 -LRB- LMP1 -RRB- to fascin and phosphorylated Stat3 in nasopharyngeal_carcinoma -RSB- .
14673102	0	latent_membrane_protein_1	19,44	NF-kappaB	59,68	latent membrane protein 1	NF-kappaB	9260	4790	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 activation of NF-kappaB through IRAK1 and TRAF6 .
16979873	0	latent_membrane_protein_1	74,99	NF-kappaB	138,147	latent membrane protein 1	NF-kappaB	9260	4790	Gene	Gene	encoded|dobj|START_ENTITY encoded|nmod|cells cells|nmod|pathways pathways|compound|END_ENTITY	Upregulated expression of kappa light chain by Epstein-Barr_virus encoded latent_membrane_protein_1 in nasopharyngeal_carcinoma cells via NF-kappaB and AP-1 pathways .
20923877	0	latent_membrane_protein_1	13,38	NF-kappaB	71,80	latent membrane protein 1	NF-kappaB	9260	4790	Gene	Gene	site|amod|START_ENTITY activates|nsubj|site activates|xcomp|END_ENTITY	Epstein-Barr latent_membrane_protein_1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419 .
20923877	0	latent_membrane_protein_1	13,38	NF-kappaB	99,108	latent membrane protein 1	NF-kappaB	9260	4790	Gene	Gene	site|amod|START_ENTITY activates|nsubj|site activates|xcomp|NF-kappaB NF-kappaB|nmod|absence absence|nmod|residues residues|amod|END_ENTITY	Epstein-Barr latent_membrane_protein_1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419 .
11783085	0	latent_membrane_protein_1	5,30	NF-kappa_B	58,68	latent membrane protein 1	NF-kappa B	9260	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	-LSB- EBV latent_membrane_protein_1 induces p53 expression via NF-kappa_B in nasopharyngeal_carcinoma -RSB- .
22880054	0	latent_membrane_protein_1	68,93	PI3K	39,43	latent membrane protein 1	PI3K	9260	5293	Gene	Gene	signaling|nmod|START_ENTITY signaling|nsubj|END_ENTITY	Src kinase and Syk activation initiate PI3K signaling by a chimeric latent_membrane_protein_1 in Epstein-Barr_virus -LRB- EBV -RRB- + B cell lymphomas .
12634403	0	latent_membrane_protein_1	43,68	STAT1	29,34	latent membrane protein 1	STAT1	9260	6772	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|END_ENTITY	Epstein-Barr_virus regulates STAT1 through latent_membrane_protein_1 .
20980631	0	latent_membrane_protein_1	4,29	TLR9	57,61	latent membrane protein 1	TLR9	9260	54106	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	EBV latent_membrane_protein_1 is a negative regulator of TLR9 .
12890376	0	latent_membrane_protein_1	27,52	TRAF1	61,66	latent membrane protein 1	TRAF1	9260	7185	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Epstein-Barr_virus encoded latent_membrane_protein_1 induces TRAF1 expression to promote anti-apoptosis activity via NF-kappaB signaling pathway in nasopharyngeal_carcinoma .
18710948	0	latent_membrane_protein_1	160,185	TRAF6	0,5	latent membrane protein 1	TRAF6	9260	7189	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent_membrane_protein_1 .
12515612	0	latent_membrane_protein_1	18,43	epidermal_growth_factor_receptor	77,109	latent membrane protein 1	epidermal growth factor receptor	9260	1956	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	-LSB- EB virus encoded latent_membrane_protein_1 modulates the phosphorylation of epidermal_growth_factor_receptor in nasopharyngeal_carcinoma cell line -RSB- .
15652339	0	latent_membrane_protein_1	124,149	epidermal_growth_factor_receptor	24,56	latent membrane protein 1	epidermal growth factor receptor	9260	1956	Gene	Gene	stage|nmod|START_ENTITY stage|nsubj|accumulation accumulation|nmod|END_ENTITY	Nuclear accumulation of epidermal_growth_factor_receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent_membrane_protein_1 .
17881446	0	latent_membrane_protein_1	79,104	epidermal_growth_factor_receptor	13,45	latent membrane protein 1	epidermal growth factor receptor	9260	1956	Gene	Gene	region|compound|START_ENTITY expression|nmod|region expression|compound|END_ENTITY	Induction of epidermal_growth_factor_receptor expression by Epstein-Barr_virus latent_membrane_protein_1 C-terminal-activating region 1 is mediated by NF-kappaB_p50 homodimer/Bcl -3 complexes .
18367518	0	latent_membrane_protein_1	19,44	epidermal_growth_factor_receptor	71,103	latent membrane protein 1	epidermal growth factor receptor	9260	1956	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 induces expression of the epidermal_growth_factor_receptor through effects on Bcl-3 and STAT3 .
20410275	0	latent_membrane_protein_1	19,44	epidermal_growth_factor_receptor	138,170	latent membrane protein 1	epidermal growth factor receptor	9260	1956	Gene	Gene	modulates|nummod|START_ENTITY distinctive|nmod:npmod|modulates NF|amod|distinctive NF|dep|pathways pathways|acl|regulate regulate|dobj|expression expression|compound|END_ENTITY	Epstein-Barr_virus latent_membrane_protein_1 modulates distinctive NF - kappaB pathways through C-terminus-activating region 1 to regulate epidermal_growth_factor_receptor expression .
22581837	0	latent_membrane_protein_1	161,186	epidermal_growth_factor_receptor	8,40	latent membrane protein 1	epidermal growth factor receptor	9260	1956	Gene	Gene	triggered|nmod|START_ENTITY triggered|nsubj|interacts interacts|compound|END_ENTITY	Nuclear epidermal_growth_factor_receptor interacts with transcriptional_intermediary_factor_2 to activate cyclin_D1 gene expression triggered by the oncoprotein latent_membrane_protein_1 .
12414666	0	latent_membrane_protein_1	19,44	fibroblast_growth_factor-2	75,101	latent membrane protein 1	fibroblast growth factor-2	9260	2247	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|END_ENTITY	Epstein-barr_virus latent_membrane_protein_1 induces and causes release of fibroblast_growth_factor-2 .
18347435	0	latent_membrane_protein_1	27,52	miR-146a	108,116	latent membrane protein 1	miR-146a	9260	406938	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Epstein-Barr_virus-encoded latent_membrane_protein_1 -LRB- LMP1 -RRB- induces the expression of the cellular microRNA miR-146a .
11783085	0	latent_membrane_protein_1	5,30	p53	39,42	latent membrane protein 1	p53	9260	7157	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	-LSB- EBV latent_membrane_protein_1 induces p53 expression via NF-kappa_B in nasopharyngeal_carcinoma -RSB- .
14762110	0	latent_transforming_growth_factor-beta_binding_protein_1	18,74	LTBP-1	76,82	latent transforming growth factor-beta binding protein 1	LTBP-1	268977(Tax:10090)	268977(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of latent_transforming_growth_factor-beta_binding_protein_1 -LRB- LTBP-1 -RRB- in dioxin receptor-null mouse embryo fibroblasts .
20157310	0	latrophilin_3	24,37	LPHN3	44,49	latrophilin 3	LPHN3	23284	23284	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common variant of the latrophilin_3 gene , LPHN3 , confers susceptibility to ADHD and predicts effectiveness of stimulant medication .
8914854	0	lauric_acid_omega-hydroxylase	39,68	CYP4A11	18,25	lauric acid omega-hydroxylase	CYP4A11	1579	1579	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of CYP4A11 as the major lauric_acid_omega-hydroxylase in human liver microsomes .
16458273	0	lc3	78,81	gabarap	25,32	lc3	gabarap	25291(Tax:10116)	58974(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|distribution distribution|nmod|END_ENTITY	Specific distribution of gabarap , gec1/gabarap Like 1 , gate16/gabarap Like 2 , lc3 messenger RNAs in rat brain areas by quantitative real-time PCR .
10190908	0	lck	145,148	CD4	105,108	lck	CD4	3932	920	Gene	Gene	p56|appos|START_ENTITY limiting|dobj|p56 thymocytes|advcl|limiting motifs|acl:relcl|thymocytes motifs|nmod|END_ENTITY	ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs -LRB- ITAMs -RRB- in immature CD4 -LRB- + -RRB- 8 -LRB- + -RRB- thymocytes with limiting p56 -LRB- lck -RRB- .
16424048	0	lck	65,68	CD4	25,28	lck	CD4	3932	920	Gene	Gene	inhibition|nmod|START_ENTITY impairs|nmod|inhibition impairs|dobj|activation activation|compound|END_ENTITY	Prostaglandin_E2 impairs CD4 + T cell activation by inhibition of lck : implications in Hodgkin 's _ lymphoma .
2107088	0	lck	125,128	CD4	75,78	lck	CD4	3932	920	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nsubj|nature nature|nmod|interaction interaction|nmod|END_ENTITY	Structural nature of the interaction between T lymphocyte surface molecule CD4 and the intracellular protein tyrosine kinase lck .
2118992	0	lck	88,91	CD4	42,45	lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY phosphorylation|nmod|kinase stimulates|dobj|phosphorylation stimulates|nsubj|Cross-linking Cross-linking|nmod|END_ENTITY	Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site .
2582490	0	lck	4,7	CD4	75,78	lck	CD4	3932	920	Gene	Gene	tyrosine|nsubj|START_ENTITY tyrosine|nmod|tail tail|nmod|glycoprotein glycoprotein|compound|END_ENTITY	The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain .
7871751	0	lck	77,80	CD4	36,39	lck	CD4	3932	920	Gene	Gene	domain|compound|START_ENTITY relevance|nmod|domain downregulation|dep|relevance downregulation|nmod|expression expression|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
7871751	0	lck	77,80	CD4	99,102	lck	CD4	3932	920	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
8871625	0	lck	100,103	CD4	48,51	lck	CD4	3932	920	Gene	Gene	association|compound|START_ENTITY overlapping|nmod|association analysis|dep|overlapping analysis|nmod|domain domain|nmod|END_ENTITY	Molecular analysis of the cytoplasmic domain of CD4 : overlapping but noncompetitive requirement for lck association and down-regulation by Nef .
9166404	0	lck	50,53	CD4	95,98	lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY membrane|nsubj|signals membrane|nmod|END_ENTITY	Intrinsic signals in the unique domain target p56 -LRB- lck -RRB- to the plasma membrane independently of CD4 .
7871751	0	lck	77,80	Nef	6,9	lck	Nef	3932	6285	Gene	Gene	domain|compound|START_ENTITY relevance|nmod|domain downregulation|dep|relevance downregulation|compound|END_ENTITY	HIV-1 Nef protein downregulation of CD4 surface expression : relevance of the lck binding domain of CD4 .
8871625	0	lck	100,103	Nef	139,142	lck	Nef	3932	6285	Gene	Gene	association|compound|START_ENTITY overlapping|nmod|association overlapping|nmod|END_ENTITY	Molecular analysis of the cytoplasmic domain of CD4 : overlapping but noncompetitive requirement for lck association and down-regulation by Nef .
12841384	0	lck	4,7	WT1	59,62	lck	WT1	16818(Tax:10090)	22431(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The lck promoter-driven expression of the Wilms_tumor gene WT1 blocks intrathymic differentiation of T-lineage cells .
10490833	0	lck	20,23	caspase-8	57,66	lck	caspase-8	3932	841	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|amod|END_ENTITY	The tyrosine kinase lck is required for CD95-independent caspase-8 activation and apoptosis in response to ionizing radiation .
10082765	0	lck	31,34	p56	27,30	lck	p56	16818(Tax:10090)	15957(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of T lymphocyte p56 -LRB- lck -RRB- , a zinc-finger signal transduction protein , is elevated by dietary_zinc_deficiency and diet restriction in mice .
10225948	0	lck	68,71	p56	64,67	lck	p56	3932	8999	Gene	Gene	Trafficking|appos|START_ENTITY Trafficking|dep|END_ENTITY	Trafficking of an acylated cytosolic protein : newly synthesized p56 -LRB- lck -RRB- travels to the plasma membrane via the exocytic pathway .
10671221	0	lck	30,33	p56	14,17	lck	p56	3932	8999	Gene	Gene	lck|nmod|START_ENTITY lck|amod|END_ENTITY	Conversion of p56 -LRB- lck -RRB- to p60 -LRB- lck -RRB- in human peripheral blood T lymphocytes is dependent on co - stimulation through accessory receptors : involvement of phospholipase C , protein kinase C and MAP-kinases in vivo .
11180123	0	lck	108,111	p56	104,107	lck	p56	3932	8999	Gene	Gene	form|appos|START_ENTITY form|amod|END_ENTITY	The cytoskeleton-associated TCR zeta chain is constitutively phosphorylated in the absence of an active p56 -LRB- lck -RRB- form .
11533187	0	lck	22,25	p56	18,21	lck	p56	3932	8999	Gene	Gene	cells|appos|START_ENTITY cells|amod|END_ENTITY	Downregulation of p56 -LRB- lck -RRB- tyrosine kinase activity in T cells of squirrel monkeys -LRB- Saimiri_sciureus -RRB- correlates with the nontransforming and apathogenic properties of herpesvirus_saimiri in its natural host .
12614879	0	lck	92,95	p56	88,91	lck	p56	3932	8999	Gene	Gene	domain|appos|START_ENTITY domain|amod|END_ENTITY	Role of solution conformation and flexibility of short peptide ligands that bind to the p56 -LRB- lck -RRB- SH2 domain .
12798323	0	lck	106,109	p56	102,105	lck	p56	3932	8999	Gene	Gene	BMS-243117|appos|START_ENTITY BMS-243117|compound|END_ENTITY	Molecular design , synthesis , and structure-Activity relationships leading to the potent and selective p56 -LRB- lck -RRB- inhibitor BMS-243117 .
19325836	0	lck	18,21	p56	14,17	lck	p56	3932	8999	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	QSAR study of p56 -LRB- lck -RRB- protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS .
8910285	0	lck	6,9	p56	2,5	lck	p56	3932	8999	Gene	Gene	ligand|compound|START_ENTITY ligand|amod|END_ENTITY	A p56 -LRB- lck -RRB- ligand serves as a coactivator of an orphan nuclear hormone receptor .
9040011	0	lck	15,18	p56	11,14	lck	p56	16818(Tax:10090)	15957(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Targets of p56 -LRB- lck -RRB- activity in immature thymoblasts : stimulation of the Ras/Raf/MAPK pathway .
9144550	0	lck	18,21	p56	14,17	lck	p56	3932	8999	Gene	Gene	turnover|compound|START_ENTITY turnover|amod|END_ENTITY	Regulation of p56 -LRB- lck -RRB- messenger turnover upon T cell activation : involvement of the 3 ' untranslated region in stability as determined in cell-free extracts .
6617981	0	lecithin-cholesterol-acyl-transferase	11,48	L-CAT	50,55	lecithin-cholesterol-acyl-transferase	L-CAT	3931	3931	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Pattern of lecithin-cholesterol-acyl-transferase -LRB- L-CAT -RRB- activity in the course of liver_cirrhosis .
11389553	0	lecithin-cholesterol_acyltransferase	21,57	Haptoglobin	0,11	lecithin-cholesterol acyltransferase	Haptoglobin	3931	3240	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Haptoglobin inhibits lecithin-cholesterol_acyltransferase in human ovarian follicular fluid .
1226995	0	lecithin-cholesterol_acyltransferase	51,87	LCAT	89,93	lecithin-cholesterol acyltransferase	LCAT	100008978(Tax:9986)	100008978(Tax:9986)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Effect of essential phospholipids -LRB- EPL -RRB- on plasma lecithin-cholesterol_acyltransferase -LRB- LCAT -RRB- activity in vivo and in vitro in the rabbit -RSB- .
8326012	0	lecithin-cholesterol_acyltransferase	45,81	LCAT	83,87	lecithin-cholesterol acyltransferase	LCAT	3931	3931	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fish_eye_syndrome : a molecular defect in the lecithin-cholesterol_acyltransferase -LRB- LCAT -RRB- gene associated with normal alpha-LCAT-specific activity .
2597674	0	lecithin-cholesterol_acyltransferase	76,112	apolipoprotein_E	31,47	lecithin-cholesterol acyltransferase	apolipoprotein E	3931	348	Gene	Gene	containing|nmod|START_ENTITY containing|dobj|END_ENTITY	Discoidal complexes containing apolipoprotein_E and their transformation by lecithin-cholesterol_acyltransferase .
3926761	0	lecithin_cholesterol_acyltransferase	14,50	apolipoprotein_E	60,76	lecithin cholesterol acyltransferase	apolipoprotein E	3931	348	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of lecithin_cholesterol_acyltransferase by human apolipoprotein_E in discoidal complexes with lipids .
19782984	0	lectin-like_oxidized_LDL_receptor	23,56	LOX-1	58,63	lectin-like oxidized LDL receptor	LOX-1	108078(Tax:10090)	108078(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Palmitic_acid enhances lectin-like_oxidized_LDL_receptor -LRB- LOX-1 -RRB- expression and promotes uptake of oxidized LDL in macrophage cells .
15380451	0	lectin-like_oxidized_LDL_receptor-1	61,96	Heparin-binding_EGF-like_growth_factor	0,38	lectin-like oxidized LDL receptor-1	Heparin-binding EGF-like growth factor	281368(Tax:9913)	522921(Tax:9913)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Heparin-binding_EGF-like_growth_factor induces expression of lectin-like_oxidized_LDL_receptor-1 in vascular smooth muscle cells .
18514661	0	lectin-like_oxidized_LDL_receptor-1	45,80	Interleukin_18	0,14	lectin-like oxidized LDL receptor-1	Interleukin 18	4973	3606	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Interleukin_18 stimulates release of soluble lectin-like_oxidized_LDL_receptor-1 -LRB- sLOX-1 -RRB- .
11573959	0	lectin-like_oxidized_LDL_receptor-1	18,53	LOX-1	55,60	lectin-like oxidized LDL receptor-1	LOX-1	140914(Tax:10116)	140914(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Diabetes enhances lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in the vascular endothelium : possible role of LOX-1 ligand and AGE .
15855339	0	lectin-like_oxidized_LDL_receptor-1	24,59	LOX-1	61,66	lectin-like oxidized LDL receptor-1	LOX-1	4973	4973	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Linoleic acid increases lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in human aortic endothelial cells .
17055514	0	lectin-like_oxidized_LDL_receptor-1	107,142	LOX-1	144,149	lectin-like oxidized LDL receptor-1	LOX-1	281368(Tax:9913)	281368(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mulberry leaf aqueous fractions inhibit TNF-alpha-induced nuclear factor kappaB -LRB- NF-kappaB -RRB- activation and lectin-like_oxidized_LDL_receptor-1 -LRB- LOX-1 -RRB- expression in vascular endothelial cells .
16790013	0	lectin-like_oxidized_low-density_lipoprotein_receptor	40,93	LOX-1	95,100	lectin-like oxidized low-density lipoprotein receptor	LOX-1	4973	4973	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Chlamydia_pneumoniae_infection enhances lectin-like_oxidized_low-density_lipoprotein_receptor -LRB- LOX-1 -RRB- expression on human endothelial cells .
9837956	0	lectin-like_oxidized_low-density_lipoprotein_receptor	57,110	LOX-1	112,117	lectin-like oxidized low-density lipoprotein receptor	LOX-1	140914(Tax:10116)	140914(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and regulation of expression of the lectin-like_oxidized_low-density_lipoprotein_receptor -LRB- LOX-1 -RRB- gene .
15797645	0	lectin-like_oxidized_low-density_lipoprotein_receptor-1	43,98	Angiotensin_II	0,14	lectin-like oxidized low-density lipoprotein receptor-1	Angiotensin II	4973	183	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases the expression of lectin-like_oxidized_low-density_lipoprotein_receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway .
15010359	0	lectin-like_oxidized_low-density_lipoprotein_receptor-1	16,71	LOX-1	73,78	lectin-like oxidized low-density lipoprotein receptor-1	LOX-1	4973	4973	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- in endothelial cells by nitric_oxide deficiency .
15480893	0	lectin-like_oxidized_low-density_lipoprotein_receptor-1	8,63	LOX-1	65,70	lectin-like oxidized low-density lipoprotein receptor-1	LOX-1	281368(Tax:9913)	281368(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- in the development of hypertensive organ damage .
18474940	0	lectin-like_oxidized_low-density_lipoprotein_receptor-1	31,86	LOX-1	88,93	lectin-like oxidized low-density lipoprotein receptor-1	LOX-1	4973	108078(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of lectin-like_oxidized_low-density_lipoprotein_receptor-1 -LRB- LOX-1 -RRB- in murine and human placentas .
18469066	0	lectin-like_oxidized_low-density_lipoprotein_receptor_1	23,78	LOX-1	80,85	lectin-like oxidized low-density lipoprotein receptor 1	LOX-1	4973	4973	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variation in the human lectin-like_oxidized_low-density_lipoprotein_receptor_1 -LRB- LOX-1 -RRB- gene is associated with plasma soluble LOX-1 levels .
12810610	0	lectin-like_oxidized_low-density_lipoprotein_receptor_1	21,76	LOX1	78,82	lectin-like oxidized low-density lipoprotein receptor 1	LOX1	4973	4973	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in lectin-like_oxidized_low-density_lipoprotein_receptor_1 -LRB- LOX1 -RRB- gene and the risk of coronary_artery_disease .
15936755	0	lef-1	118,123	Beta-catenin	0,12	lef-1	Beta-catenin	51176	1499	Gene	Gene	lymphocyte_enhancer_factor-1|dep|START_ENTITY receptor|amod|lymphocyte_enhancer_factor-1 act|nmod|receptor act|nsubj|END_ENTITY	Beta-catenin can act as a nuclear import receptor for its partner transcription factor , lymphocyte_enhancer_factor-1 -LRB- lef-1 -RRB- .
23942113	0	legumain	34,42	p53	51,54	legumain	p53	5641	7157	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the legumain gene by p53 in HCT116 cells .
24604027	0	lens_epithelial-derived_growth_factor	63,100	LEDGF	102,107	lens epithelial-derived growth factor	LEDGF	11168	11168	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Oncogenic human papillomaviruses activate the tumor-associated lens_epithelial-derived_growth_factor -LRB- LEDGF -RRB- gene .
7796604	0	lens_intrinsic_membrane_protein_MP70	10,46	Cx50	48,52	lens intrinsic membrane protein MP70	Cx50	2703	2703	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human lens_intrinsic_membrane_protein_MP70 -LRB- Cx50 -RRB- gene : clonal analysis and chromosome mapping .
15297702	0	lens_rupture_2	75,89	Nefl	21,25	lens rupture 2	Nefl	68813(Tax:10090)	18039(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Fine localization of Nefl and Nef3 and its exclusion as candidate gene for lens_rupture_2 -LRB- lr2 -RRB- .
22971074	0	leptin	57,63	11beta-HSD2	65,76	leptin	11beta-HSD2	3952	3291	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Corticotropin-releasing_hormone stimulates expression of leptin , 11beta-HSD2 and syncytin-1 in primary human trophoblasts .
22592205	0	leptin	15,21	Adiponectin	0,11	leptin	Adiponectin	3952	9370	Gene	Gene	index|compound|START_ENTITY END_ENTITY|nmod|index	Adiponectin to leptin index as a marker of endometrial_cancer in postmenopausal women with abnormal vaginal_bleeding : an observational study .
23115066	0	leptin	13,19	Adiponectin	0,11	leptin	Adiponectin	3952	9370	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|appos|concentrations	Adiponectin , leptin , resistin and insulin blood concentrations in patients with ischaemic_cerebral_stroke .
22967108	0	leptin	94,100	Akt	147,150	leptin	Akt	25608(Tax:10116)	24185(Tax:10116)	Gene	Gene	signalling|compound|START_ENTITY pathway|nmod|signalling regulator|nmod|pathway regulator|acl:relcl|involve involve|dobj|activation activation|nmod|END_ENTITY	Phosphatidylinositol_3-kinase is an upstream regulator of the phosphodiesterase_3B pathway of leptin signalling that may not involve activation of Akt in the rat hypothalamus .
24063596	0	leptin	60,66	Angiotensin_II	0,14	leptin	Angiotensin II	25608(Tax:10116)	24179(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY mediate|dobj|induction mediate|nsubj|END_ENTITY	Angiotensin_II and the ERK pathway mediate the induction of leptin by mechanical cyclic stretch in cultured rat neonatal cardiomyocytes .
11829320	0	leptin	6,12	C-reactive_protein	54,72	leptin	C-reactive protein	3952	1401	Gene	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	Serum leptin levels in septic men correlate well with C-reactive_protein -LRB- CRP -RRB- and TNF-alpha but not with BMI .
21738237	0	leptin	54,60	C-reactive_protein	0,18	leptin	C-reactive protein	3952	1401	Gene	Gene	association|nmod|START_ENTITY modifies|dobj|association modifies|nsubj|END_ENTITY	C-reactive_protein modifies the association of plasma leptin with coronary calcium in asymptomatic overweight individuals .
15500001	0	leptin	11,17	CA_III	33,39	leptin	CA III	25608(Tax:10116)	54232(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of leptin and insulin on CA_III expression in rat adipose tissue .
25337653	0	leptin	23,29	COL6A3	0,6	leptin	COL6A3	3952	1293	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	COL6A3 is regulated by leptin in human adipose_tissue and reduced in obesity .
14550255	0	leptin	41,47	Cholecystokinin	0,15	leptin	Cholecystokinin	3952	885	Gene	Gene	synthesizes|dobj|START_ENTITY synthesizes|nsubj|END_ENTITY	Cholecystokinin synthesizes and secretes leptin in isolated canine gastric chief cells .
17409452	0	leptin	15,21	E-cadherin	35,45	leptin	E-cadherin	3952	999	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Evidences that leptin up-regulates E-cadherin expression in breast_cancer : effects on tumor growth and progression .
19066310	0	leptin	79,85	ERK	13,16	leptin	ERK	25608(Tax:10116)	24338(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin .
19385085	0	leptin	46,52	Egr-1	0,5	leptin	Egr-1	25608(Tax:10116)	24330(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nsubjpass|END_ENTITY	Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro .
25112714	0	leptin	28,34	FNDC5	0,5	leptin	FNDC5	3952	252995	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	FNDC5 could be regulated by leptin in adipose tissue .
22326952	0	leptin	15,21	FOSL2	0,5	leptin	FOSL2	3952	2355	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	FOSL2 promotes leptin gene expression in human and mouse adipocytes .
11900968	0	leptin	52,58	GH	102,104	leptin	GH	443534(Tax:9940)	443329(Tax:9940)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of intravenous infusion of recombinant ovine leptin on feed intake and serum concentrations of GH , LH , insulin , IGF-1 , cortisol , and thyroxine in growing prepubertal ewe lambs .
9302388	0	leptin	55,61	GH	37,39	leptin	GH	3952	2688	Gene	Gene	status|appos|START_ENTITY status|appos|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- status , serum leptin and body composition in healthy and GH_deficient elderly subjects .
9678531	0	leptin	58,64	GH	128,130	leptin	GH	3952	2688	Gene	Gene	levels|nmod|START_ENTITY levels|dep|lack lack|nmod|impact impact|nmod|modes modes|nmod|administration administration|compound|END_ENTITY	Increased levels but preserved diurnal variation of serum leptin in GH-deficient patients : lack of impact of different modes of GH administration .
9768649	0	leptin	57,63	GH	26,28	leptin	GH	3952	2688	Gene	Gene	concentrations|nmod|START_ENTITY growth_hormone|nmod|concentrations growth_hormone|appos|END_ENTITY	Effect of growth_hormone -LRB- GH -RRB- on serum concentrations of leptin : study in patients with acromegaly and GH_deficiency .
9867083	0	leptin	24,30	GH	61,63	leptin	GH	3952	2688	Gene	Gene	expression|compound|START_ENTITY expression|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Serum leptin levels and leptin expression in growth_hormone -LRB- GH -RRB- - deficient and healthy adults : influence of GH treatment , gender , and fasting .
9867083	0	leptin	6,12	GH	108,110	leptin	GH	3952	2688	Gene	Gene	levels|compound|START_ENTITY levels|dep|influence influence|nmod|treatment treatment|compound|END_ENTITY	Serum leptin levels and leptin expression in growth_hormone -LRB- GH -RRB- - deficient and healthy adults : influence of GH treatment , gender , and fasting .
10708552	0	leptin	10,16	GLP-1	33,38	leptin	GLP-1	25608(Tax:10116)	24952(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|peptide peptide|compound|END_ENTITY	Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNA .
24025512	0	leptin	27,33	GSK-3b	49,55	leptin	GSK-3b	16846(Tax:10090)	56637(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	-LSB- APPL1-mediated effects of leptin on activity of GSK-3b in C2C12 cell -RSB- .
10333553	0	leptin	33,39	Growth_hormone	0,14	leptin	Growth hormone	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Growth_hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats .
10681635	0	leptin	45,51	Growth_hormone	0,14	leptin	Growth hormone	3952	2688	Gene	Gene	levels|compound|START_ENTITY serum|dobj|levels serum|nsubj|downregulates downregulates|amod|END_ENTITY	Growth_hormone treatment downregulates serum leptin levels in children independent of changes in body mass index .
23261058	0	leptin	27,33	HER2	0,4	leptin	HER2	3952	2064	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	HER2 induces expression of leptin in human breast epithelial cells .
10607937	0	leptin	25,31	IGF-1	99,104	leptin	IGF-1	280836(Tax:9913)	281239(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|expression expression|compound|END_ENTITY	Growth hormone regulates leptin gene expression in bovine adipose tissue : correlation with adipose IGF-1 expression .
24854528	0	leptin	44,50	IGF-1	52,57	leptin	IGF-1	3952	3479	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	The effect of adenotonsilectomy on ghrelin , leptin , IGF-1 levels and growth parameters in children with adenotonsillar_hypertrophy .
25141780	0	leptin	143,149	IGF-1	126,131	leptin	IGF-1	3952	3479	Gene	Gene	change|compound|START_ENTITY system|appos|change relationship|dep|system relationship|nmod|intensity intensity|appos|factor factor|appos|END_ENTITY	The relationship between moderate-to-vigorous intensity physical activity and insulin resistance , insulin-like growth factor -LRB- IGF-1 -RRB- - system 1 , leptin and weight change in healthy women during pregnancy and after delivery .
11916623	0	leptin	32,38	IGF-I	40,45	leptin	IGF-I	3952	3479	Gene	Gene	Associations|acl|START_ENTITY Associations|acl|END_ENTITY	Associations between body mass , leptin , IGF-I and circulating adrenal androgens in children with obesity and premature_adrenarche .
12054113	0	leptin	20,26	IGF-I	51,56	leptin	IGF-I	3952	3479	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|parataxis|axis axis|nsubj|END_ENTITY	Interaction between leptin and growth_hormone -LRB- GH -RRB- / IGF-I axis .
12864793	0	leptin	69,75	IGF-I	40,45	leptin	IGF-I	3952	3479	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	The effect of pegvisomant-induced serum IGF-I normalization on serum leptin levels in patients with acromegaly .
14983407	0	leptin	51,57	IGF-I	37,42	leptin	IGF-I	3952	3479	Gene	Gene	variables|compound|START_ENTITY D3|appos|variables D3|appos|system system|amod|END_ENTITY	Relationship between 25 - -LRB- OH -RRB- _ D3 , the IGF-I system , leptin , anthropometric and body composition variables in a healthy , randomly selected population .
17020145	0	leptin	22,28	IGF-I	7,12	leptin	IGF-I	396832(Tax:9823)	397491(Tax:9823)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Gh and IGF-I increase leptin receptor expression in prepubertal pig ovaries : the role of leptin in steroid secretion and cell apoptosis .
9822950	0	leptin	80,86	IGF-I	48,53	leptin	IGF-I	3952	3479	Gene	Gene	concentration|compound|START_ENTITY decreases|dobj|concentration decreases|nsubj|insulin-like_growth_factor-I insulin-like_growth_factor-I|appos|END_ENTITY	Recombinant human insulin-like_growth_factor-I -LRB- IGF-I -RRB- therapy decreases plasma leptin concentration in patients with chronic_renal_insufficiency .
9829217	0	leptin	6,12	IGF-I	69,74	leptin	IGF-I	3952	3479	Gene	Gene	START_ENTITY|nmod|treatment treatment|amod|END_ENTITY	Serum leptin in obese patients with Laron_syndrome before and during IGF-I treatment .
11248749	0	leptin	63,69	IGF_binding_protein-1	12,33	leptin	IGF binding protein-1	3952	3484	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Circulating IGF_binding_protein-1 is inversely associated with leptin in non-obese men and obese postmenopausal women .
9458919	0	leptin	19,25	IL-1_beta	0,9	leptin	IL-1 beta	16846(Tax:10090)	16176(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY mediates|dobj|induction mediates|nsubj|END_ENTITY	IL-1_beta mediates leptin induction during inflammation .
15304373	0	leptin	69,75	IL-1beta	41,49	leptin	IL-1beta	25608(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids : implications for energy homeostasis .
17617622	0	leptin	46,52	IL-6	15,19	leptin	IL-6	3952	3569	Gene	Gene	receptor|compound|START_ENTITY mediated|nmod|receptor mediated|nsubjpass|production production|compound|END_ENTITY	Leptin-induced IL-6 production is mediated by leptin receptor , insulin receptor substrate-1 , phosphatidylinositol 3-kinase , Akt , NF-kappaB , and p300 pathway in microglia .
18501560	0	leptin	35,41	IL-8	15,19	leptin	IL-8	3952	3576	Gene	Gene	cascade|amod|START_ENTITY expression|nmod|cascade expression|compound|END_ENTITY	Leptin induces IL-8 expression via leptin receptor , IRS-1 , PI3K , Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts .
12668159	0	leptin	41,47	IP-10	0,5	leptin	IP-10	3952	3627	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	IP-10 , but not RANTES , is upregulated by leptin in monocytic cells .
10353113	0	leptin	104,110	Insulin	1,8	leptin	Insulin	3952	3630	Gene	Gene	-RSB-|compound|START_ENTITY determinants|nmod|-RSB- constitute|dobj|determinants constitute|nsubj|END_ENTITY	-LSB- Insulin secretion in women and insulin_sensitivity in men constitute independent determinants of serum leptin concentration -RSB- .
10447517	0	leptin	24,30	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	concentrations|compound|START_ENTITY increases|dobj|concentrations increases|nsubj|END_ENTITY	Insulin increases serum leptin concentrations in children and adolescents with newly diagnosed type_I_diabetes_mellitus with and without ketoacidosis .
10833328	0	leptin	18,24	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans .
10875631	0	leptin	22,28	Insulin	0,7	leptin	Insulin	396832(Tax:9823)	397415(Tax:9823)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Insulin regulation of leptin expression in streptozotocin diabetic pigs .
10968481	0	leptin	91,97	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	variation|nmod|START_ENTITY determinants|nmod|variation determinants|nsubj|END_ENTITY	Insulin and insulin resistance index are not independent determinants for the variation in leptin in obese children and adolescents .
11387233	0	leptin	52,58	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes .
12935365	0	leptin	20,26	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Insulin resistance , leptin and TNF-alpha system in morbidly obese women after gastric bypass .
19267279	0	leptin	20,26	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|dobj|levels	Insulin resistance , leptin and monocyte_chemotactic_protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects .
23718986	0	leptin	17,23	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Insulin enhances leptin expression in human trophoblastic cells .
8826983	0	leptin	29,35	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	production|compound|START_ENTITY promote|dobj|production promote|nsubj|END_ENTITY	Insulin and cortisol promote leptin production in cultured human fat cells .
8858224	0	leptin	25,31	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	concentrations|compound|START_ENTITY increases|dobj|concentrations increases|nsubj|END_ENTITY	Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM .
9690055	0	leptin	66,72	Insulin	0,7	leptin	Insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY effect|nmod|levels have|dobj|effect have|nsubj|END_ENTITY	Insulin and body fat distribution have no direct effect on plasma leptin levels in obese Caucasian women with and without type_2_diabetes_mellitus .
12101078	0	leptin	28,34	Interferon-alpha	0,16	leptin	Interferon-alpha	3952	111654(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Interferon-alpha suppresses leptin levels : studies in interferon-alpha treated patients with hepatitis_C virus infection and murine adipocytes .
9284748	0	leptin	36,42	Interleukin_1_alpha	0,19	leptin	Interleukin 1 alpha	3952	3552	Gene	Gene	concentrations|compound|START_ENTITY increases|dobj|concentrations increases|nsubj|END_ENTITY	Interleukin_1_alpha increases serum leptin concentrations in humans .
16503925	0	leptin	39,45	KiSS-1	0,6	leptin	KiSS-1	16846(Tax:10090)	280287(Tax:10090)	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|neurones neurones|amod|END_ENTITY	KiSS-1 neurones are direct targets for leptin in the ob/ob mouse .
23049591	0	leptin	10,16	KiSS-1	39,45	Leptin	KiSS-1	16846(Tax:10090)	280287(Tax:10090)	Gene	Gene	Excess|nmod|START_ENTITY inhibits|nsubj|Excess inhibits|dobj|expression expression|compound|END_ENTITY	Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice .
11531701	0	leptin	26,32	LEP	34,37	leptin	LEP	396832(Tax:9823)	396832(Tax:9823)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of swine leptin -LRB- LEP -RRB- polymorphisms and their association with production traits .
16261186	0	leptin	41,47	LEP	54,57	leptin	LEP	3952	3952	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Microsatellite polymorphism of the human leptin gene -LRB- LEP -RRB- and risk of cardiovascular_disease .
23544120	0	leptin	79,85	LEP	87,90	leptin	LEP	16846(Tax:10090)	16846(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Chito-oligosaccharide inhibits the de-methylation of a ` CpG ' island within the leptin -LRB- LEP -RRB- promoter during adipogenesis of 3T3-L1 cells .
24823393	0	leptin	32,38	LEP	48,51	leptin	LEP	3952	3952	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Discovery of a novel functional leptin protein -LRB- LEP -RRB- in zebra_finches : evidence for the existence of an authentic avian leptin gene predominantly expressed in the brain and pituitary .
27075752	0	leptin	25,31	LEP	33,36	leptin	LEP	3952	3952	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The p. _ N103K mutation of leptin -LRB- LEP -RRB- gene and severe early onset obesity in Pakistan .
10426312	0	leptin	14,20	Lep	24,27	leptin	Lep	3952	3952	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	The effect of leptin on Lep expression is tissue-specific and nutritionally regulated .
12643450	0	leptin	8,14	Leptin	0,6	leptin	Leptin	3952	3952	Gene	Gene	resistance|compound|START_ENTITY END_ENTITY|appos|resistance	Leptin , leptin resistance and endothelial_dysfunction in pre-eclampsia .
15950978	0	leptin	42,48	Leptin	0,6	leptin	Leptin	3952	3952	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Leptin receptor and functional effects of leptin in human endothelial progenitor cells .
17635573	0	leptin	8,14	Leptin	0,6	leptin	Leptin	3952	3952	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Leptin , leptin soluble receptor and coronary_atherosclerosis .
18050615	0	leptin	9,15	Leptin	1,7	leptin	Leptin	3952	3952	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	-LSB- Leptin , leptin gene , leptin gene receptor polymorphisms and pregnancy -RSB- .
21584748	0	leptin	8,14	Leptin	0,6	leptin	Leptin	3952	3952	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Leptin , leptin gene and leptin_receptor gene polymorphism in heart_failure with preserved ejection fraction .
25010649	0	leptin	47,53	Leptin	0,6	leptin	Leptin	3952	3952	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Leptin as an uremic toxin : Deleterious role of leptin in chronic_kidney_disease .
9024259	0	leptin	36,42	Leptin	0,6	leptin	Leptin	3952	3952	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|dep|levels	Leptin in human reproduction : serum leptin levels in pregnant and lactating women .
23558862	0	leptin	49,55	Leptin_receptor	0,15	leptin	Leptin receptor	3952	3953	Gene	Gene	concentration|compound|START_ENTITY mRNA|dobj|concentration mRNA|nsubj|END_ENTITY	Leptin_receptor -LRB- Ob-R -RRB- mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal_cancer .
16136022	0	leptin	26,32	NPY	53,56	leptin	NPY	3952	4852	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Prospective evaluation of leptin and neuropeptide_Y -LRB- NPY -RRB- serum levels in girls with anorexia_nervosa .
19665393	0	leptin	114,120	OB-R	108,112	leptin	OB-R	3952	3953	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Expression patterns of leptin_receptor -LRB- OB-R -RRB- isoforms and direct in vitro effects of recombinant leptin on OB-R , leptin expression and cytokine secretion by human hematopoietic malignant cells .
19665393	0	leptin	98,104	OB-R	108,112	leptin	OB-R	3952	3953	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Expression patterns of leptin_receptor -LRB- OB-R -RRB- isoforms and direct in vitro effects of recombinant leptin on OB-R , leptin expression and cytokine secretion by human hematopoietic malignant cells .
11549696	0	leptin	89,95	Ob-R	47,51	leptin	Ob-R	3952	3953	Gene	Gene	secretion|compound|START_ENTITY regulation|nmod|secretion fibroblasts|dep|regulation _|nmod|fibroblasts _|dobj|and_leptin_receptor and_leptin_receptor|appos|END_ENTITY	Expression of leptin _ -LRB- Ob -RRB- _ and_leptin_receptor -LRB- Ob-R -RRB- in human fibroblasts : regulation of leptin secretion by insulin .
23558862	0	leptin	49,55	Ob-R	17,21	leptin	Ob-R	3952	3953	Gene	Gene	concentration|compound|START_ENTITY mRNA|dobj|concentration mRNA|nsubj|Leptin_receptor Leptin_receptor|appos|END_ENTITY	Leptin_receptor -LRB- Ob-R -RRB- mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal_cancer .
11748924	0	leptin	6,12	PI3K	23,27	leptin	PI3K	3952	5295	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|pathways pathways|compound|END_ENTITY	Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells : possible role of Sam68 .
17229473	0	leptin	72,78	PI3K	8,12	leptin	PI3K	25608(Tax:10116)	298947(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin .
21085763	0	leptin	62,68	PI3K	4,8	leptin	PI3K	3952	5293	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	The PI3K signaling pathway mediates the biological effects of leptin .
21270124	0	leptin	152,158	PI3K	100,104	leptin	PI3K	25608(Tax:10116)	298947(Tax:10116)	Gene	Gene	implications|nmod|START_ENTITY pathways|dep|implications signaling|dobj|pathways mediated|xcomp|signaling mediated|nmod|END_ENTITY	Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways : implications for leptin as a regulator of short term satiety .
21270124	0	leptin	32,38	PI3K	100,104	leptin	PI3K	25608(Tax:10116)	298947(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY mediated|nsubjpass|interaction mediated|nmod|END_ENTITY	Synergistic interaction between leptin and cholecystokinin in the rat nodose ganglia is mediated by PI3K and STAT3 signaling pathways : implications for leptin as a regulator of short term satiety .
24058635	0	leptin	44,50	PI3K	96,100	leptin	PI3K	16846(Tax:10090)	18708(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY increases|dobj|levels increases|nmod|time time|nmod|adipocytes adipocytes|nmod|activation activation|compound|END_ENTITY	Triiodothyronine increases mRNA and protein leptin levels in short time in 3T3-L1 adipocytes by PI3K pathway activation .
10989952	0	leptin	90,96	PPARgamma	11,20	leptin	PPARgamma	3952	5468	Gene	Gene	levels|compound|START_ENTITY affect|dobj|levels CAC|parataxis|affect CAC|nsubj|exon exon|compound|END_ENTITY	The silent PPARgamma exon 6 CAC -LRB- His -RRB- _ -- > _ CAT -LRB- His -RRB- polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany .
15114521	0	leptin	53,59	PPARgamma	11,20	leptin	PPARgamma	25608(Tax:10116)	25664(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY agonists|nmod|levels agonists|nsubj|Effects Effects|nmod|END_ENTITY	Effects of PPARgamma and PPARalpha agonists on serum leptin levels in diet-induced obese rats .
17909895	0	leptin	129,135	PPARgamma	54,63	leptin	PPARgamma	16846(Tax:10090)	19016(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY ligand|dobj|levels ligand|nsubj|peroxisome_proliferator_activated_receptor_gamma peroxisome_proliferator_activated_receptor_gamma|appos|END_ENTITY	The peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin , adiponectin , and inflammatory cytokines in lean and obese mice .
19385085	0	leptin	46,52	PPARgamma	56,65	leptin	PPARgamma	25608(Tax:10116)	25664(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY involved|nmod|effect involved|nmod|expression expression|compound|END_ENTITY	Egr-1 is involved in the inhibitory effect of leptin on PPARgamma expression in hepatic stellate cell in vitro .
17088410	0	leptin	18,24	Prolactin	0,9	leptin	Prolactin	280836(Tax:9913)	280901(Tax:9913)	Gene	Gene	action|compound|START_ENTITY affects|dobj|action affects|nsubj|END_ENTITY	Prolactin affects leptin action in the bovine mammary gland via the mammary fat pad .
17565041	0	leptin	15,21	SH2B1	0,5	leptin	SH2B1	3952	25970	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	SH2B1 enhances leptin signaling by both Janus_kinase_2 Tyr813 phosphorylation-dependent and - independent mechanisms .
19408656	0	leptin	27,33	SOCS-3	51,57	leptin	leptin	25608(Tax:10116)	25608(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of rat recombinant leptin on expression of SOCS-3 in mature adipocytes -RSB- .
12049654	0	leptin	72,78	STAT3	114,119	leptin	STAT3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	kinase|nmod|START_ENTITY regulation|nmod|kinase regulation|dep|role role|acl|regulating regulating|dobj|phosphorylation phosphorylation|nummod|END_ENTITY	Biphasic regulation of extracellular-signal-regulated protein kinase by leptin in macrophages : role in regulating STAT3 Ser727 phosphorylation and DNA binding .
16814732	0	leptin	26,32	STAT3	17,22	leptin	STAT3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	actions|nmod:poss|START_ENTITY role|nmod|actions role|nmod|END_ENTITY	Critical role of STAT3 in leptin 's metabolic actions .
19049975	0	leptin	15,21	STAT3	87,92	leptin	STAT3	3952	6774	Gene	Gene	regulation|compound|START_ENTITY inhibits|dobj|regulation inhibits|advcl|blocking blocking|dobj|interaction interaction|compound|END_ENTITY	FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity_protein_1 .
22158477	0	leptin	19,25	STAT3	84,89	leptin	STAT3	25608(Tax:10116)	25125(Tax:10116)	Gene	Gene	Neuroprotection|nmod|START_ENTITY Neuroprotection|dep|effects effects|nmod|phosphorylation phosphorylation|nummod|END_ENTITY	Neuroprotection by leptin in a rat model of permanent cerebral_ischemia : effects on STAT3 phosphorylation in discrete cells of the brain .
23462572	0	leptin	23,29	STAT3	66,71	leptin	STAT3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|pathway pathway|compound|END_ENTITY	Detrimental effects of leptin on intracerebral_hemorrhage via the STAT3 signal pathway .
25576055	0	leptin	81,87	STAT3	28,33	leptin	STAT3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	sensitivity|compound|START_ENTITY dictates|dobj|sensitivity dictates|nsubj|Enhancement Enhancement|nmod|acetylation acetylation|compound|END_ENTITY	Enhancement of hypothalamic STAT3 acetylation by nuclear receptor Nur77 dictates leptin sensitivity .
23295202	0	leptin	43,49	Stat3	0,5	leptin	Stat3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY correlates|nmod|roles correlates|nsubj|END_ENTITY	Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol_regulatory_element_binding_protein-1c expression of rat hepatic stellate cells .
12135690	0	leptin	56,62	TNF-R1	7,13	leptin	TNF-R1	3952	7132	Gene	Gene	levels|compound|START_ENTITY END_ENTITY|nmod|levels	Plasma TNF-R1 and insulin concentrations in relation to leptin levels among normal and overweight children .
10666158	0	leptin	42,48	TNF_receptor	76,88	leptin	TNF receptor	16846(Tax:10090)	21937(Tax:10090)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Tumor_necrosis_factor _ -LRB- TNF -RRB- - alpha induces leptin production through the p55 TNF_receptor .
11882596	0	leptin	40,46	Thyrotropin-releasing_hormone	0,29	leptin	Thyrotropin-releasing hormone	25608(Tax:10116)	25569(Tax:10116)	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Thyrotropin-releasing_hormone decreases leptin and mediates the leptin-induced pressor effect .
10891886	0	leptin	83,89	Tumor_necrosis_factor-alpha	0,27	leptin	Tumor necrosis factor-alpha	3952	7124	Gene	Gene	cytokine|appos|START_ENTITY secretion|nmod|cytokine regulates|dobj|secretion regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates secretion of the adipocyte-derived cytokine , leptin .
15841796	0	leptin	10,16	VEGF	83,87	leptin	VEGF	16846(Tax:10090)	22339(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of leptin on proliferative activity and vascular endothelial growth factor -LRB- VEGF -RRB- secretion from cultured endothelial cells HECa10 in vitro .
17403719	0	leptin	107,113	adiponectin	18,29	leptin	adiponectin	3952	9370	Gene	Gene	relationship|nmod|START_ENTITY Increase|dep|relationship Increase|nmod|concentration concentration|compound|END_ENTITY	Increase in serum adiponectin concentration in patients with heart_failure and cachexia : relationship with leptin , other cytokines , and B-type_natriuretic_peptide .
18191043	0	leptin	16,22	adiponectin	49,60	leptin	adiponectin	3952	9370	Gene	Gene	weight|compound|START_ENTITY Significance|nmod|weight END_ENTITY|nsubj|Significance	Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents .
18370715	0	leptin	4,10	adiponectin	14,25	leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	The leptin to adiponectin ratio is a good biomarker for the prevalence of metabolic_syndrome , dependent_on_visceral_fat_accumulation and endurance fitness in obese patients with diabetes_mellitus .
18925326	0	leptin	21,27	adiponectin	29,40	leptin	adiponectin	3952	9370	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	The relationships of leptin , adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs .
19482706	0	leptin	26,32	adiponectin	14,25	leptin	adiponectin	3952	9370	Gene	Gene	ratio|compound|START_ENTITY Targeting|dep|ratio Targeting|dep|END_ENTITY	Targeting the adiponectin : leptin ratio for postmenopausal_breast_cancer prevention .
19855365	0	leptin	21,27	adiponectin	8,19	leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|nsubj|Leptin Leptin|appos|END_ENTITY	Leptin , adiponectin , leptin to adiponectin ratio and insulin resistance in depressive women .
20722673	0	leptin	21,27	adiponectin	45,56	leptin	adiponectin	3952	9370	Gene	Gene	Associations|nmod|START_ENTITY Associations|dep|ratio ratio|compound|END_ENTITY	Associations between leptin and the leptin / adiponectin ratio and incident Type 2 diabetes in middle-aged men and women : results from the MONICA / KORA Augsburg study 1984-2002 .
21274300	0	leptin	73,79	adiponectin	148,159	leptin	adiponectin	3952	9370	Gene	Gene	levels|dep|START_ENTITY relationship|nmod|levels relationship|parataxis|marker marker|nsubj|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
21274300	0	leptin	73,79	adiponectin	31,42	leptin	adiponectin	3952	9370	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
21348878	0	leptin	15,21	adiponectin	31,42	leptin	adiponectin	3952	9370	Gene	Gene	Reliability|nmod|START_ENTITY END_ENTITY|nsubj|Reliability	Reliability of leptin , but not adiponectin , as a biomarker for diet-induced weight_loss in humans .
21821964	0	leptin	19,25	adiponectin	51,62	leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|nmod|ratio ratio|compound|END_ENTITY	Association of the leptin to high-molecular-weight adiponectin ratio with metabolic_syndrome .
21986458	0	leptin	90,96	adiponectin	98,109	leptin	adiponectin	3952	9370	Gene	Gene	visfatin|compound|START_ENTITY visfatin|dep|END_ENTITY	The effect of three-month pre-season preparatory period and short-term exercise on plasma leptin , adiponectin , visfatin , and ghrelin levels in young female handball and basketball players .
22179449	0	leptin	6,12	adiponectin	77,88	leptin	adiponectin	3952	9370	Gene	Gene	levels|compound|START_ENTITY correlated|nsubjpass|levels correlated|nmod|expression expression|nmod|END_ENTITY	Serum leptin levels are inversely correlated with omental gene expression of adiponectin and markedly decreased after gastric_bypass_surgery .
23505188	0	leptin	19,25	adiponectin	27,38	leptin	adiponectin	3952	9370	Gene	Gene	START_ENTITY|appos|levels levels|compound|END_ENTITY	Maternal and fetal leptin , adiponectin levels and associations with fetal_insulin_sensitivity .
24052207	0	leptin	61,67	adiponectin	48,59	leptin	adiponectin	3952	9370	Gene	Gene	resistin|dep|START_ENTITY resistin|compound|END_ENTITY	Relationships between serum adipocyte hormones -LRB- adiponectin , leptin , resistin -RRB- , bone_mineral_density and bone metabolic markers in osteoporosis patients .
25690094	0	leptin	59,65	adiponectin	34,45	leptin	adiponectin	3952	9370	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Fish oil N-3_Fatty_acids increase adiponectin and decrease leptin levels in patients with systemic_lupus_erythematosus .
26374448	0	leptin	24,30	adiponectin	34,45	leptin	adiponectin	3952	9370	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Differential effects of leptin on adiponectin expression with weight_gain_versus_obesity .
26374448	0	leptin	24,30	adiponectin	34,45	leptin	adiponectin	3952	9370	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Differential effects of leptin on adiponectin expression with weight_gain_versus_obesity .
16236269	0	leptin	10,16	alcohol_dehydrogenase	26,47	leptin	alcohol dehydrogenase	3952	10327	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of leptin on liver alcohol_dehydrogenase .
16806260	0	leptin	22,28	angiotensin_II	84,98	leptin	angiotensin II	25608(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|acl|mediating mediating|dobj|effects effects|nmod|END_ENTITY	An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin_II and endothelin-1 .
21806545	0	leptin	54,60	angiotensin_II	83,97	leptin	angiotensin II	3952	183	Gene	Gene	expression|compound|START_ENTITY atorvastatin|nmod|expression effect|nmod|atorvastatin Mechanism|nmod|effect induced|nsubj|Mechanism induced|nmod|END_ENTITY	Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin_II in cultured human coronary artery smooth muscle cells .
19481557	0	leptin	37,43	apolipoprotein_E	17,33	leptin	apolipoprotein E	16846(Tax:10090)	11816(Tax:10090)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of apolipoprotein_E by leptin in the hypothalamus of mice and rats .
12704399	0	leptin	96,102	brain-derived_neurotrophic_factor	42,75	leptin	brain-derived neurotrophic factor	16846(Tax:10090)	12064(Tax:10090)	Gene	Gene	resistance|compound|START_ENTITY effects|nmod|resistance effects|nmod|END_ENTITY	Anti-obesity and anti-diabetic effects of brain-derived_neurotrophic_factor in rodent models of leptin resistance .
10991976	0	leptin	60,66	cholecystokinin	19,34	leptin	cholecystokinin	25608(Tax:10116)	25298(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Gastric effects of cholecystokinin and its interaction with leptin on brainstem neuronal activity in neonatal rats .
17065401	0	leptin	80,86	corticotropin-releasing_factor	14,44	leptin	corticotropin-releasing factor	25608(Tax:10116)	81648(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of corticotropin-releasing_factor and its types 1 and 2 receptors by leptin in rats subjected to treadmill running-induced stress .
9528930	0	leptin	11,17	corticotropin-releasing_factor	21,51	leptin	corticotropin-releasing factor	16846(Tax:10090)	12918(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|synthesis synthesis|amod|END_ENTITY	Effects of leptin on corticotropin-releasing_factor -LRB- CRF -RRB- synthesis and CRF neuron activation in the paraventricular hypothalamic nucleus of obese -LRB- ob/ob -RRB- mice .
9604864	0	leptin	89,95	corticotropin-releasing_hormone	13,44	leptin	corticotropin-releasing hormone	25608(Tax:10116)	81648(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY mediator|nmod|effect mediator|nsubj|END_ENTITY	Hypothalamic corticotropin-releasing_hormone is a mediator of the anorexigenic effect of leptin .
18988190	0	leptin	14,20	cyclin_D1	62,71	leptin	cyclin D1	3952	595	Gene	Gene	Evidence|acl:relcl|START_ENTITY enhances|nsubj|Evidence enhances|dobj|expression expression|amod|END_ENTITY	Evidence that leptin through STAT and CREB signaling enhances cyclin_D1 expression and promotes human endometrial_cancer proliferation .
26693747	0	leptin	31,37	cystatin_C	15,25	leptin	cystatin C	3952	1471	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of cystatin_C with leptin and TNF-a in elderly Japanese women .
10077348	0	leptin	6,12	growth_hormone	64,78	leptin	growth hormone	3952	2688	Gene	Gene	concentrations|compound|START_ENTITY concentrations|nmod|administration administration|nmod|END_ENTITY	Serum leptin concentrations during short-term administration of growth_hormone and triiodothyronine in healthy adults : a randomised , double-blind placebo-controlled study .
10484132	0	leptin	46,52	growth_hormone	11,25	leptin	growth hormone	373955(Tax:9031)	378781(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of growth_hormone and pair-feeding on leptin mRNA expression in liver and adipose tissue .
10523000	0	leptin	6,12	growth_hormone	35,49	leptin	growth hormone	3952	2688	Gene	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|secretion secretion|amod|END_ENTITY	Serum leptin levels correlate with growth_hormone secretion and body fat in children .
10614542	0	leptin	85,91	growth_hormone	42,56	leptin	growth hormone	3952	2688	Gene	Gene	levels|amod|START_ENTITY alter|dobj|levels alter|nsubj|changes changes|nmod|levels levels|amod|END_ENTITY	Arginine infusion and/or acute changes of growth_hormone levels do not acutely alter leptin serum levels .
11022201	0	leptin	101,107	growth_hormone	63,77	leptin	growth hormone	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	resistance|compound|START_ENTITY involvement|nmod|resistance Development|dep|involvement Development|nmod|obesity obesity|nmod|rats rats|nmod|levels levels|compound|END_ENTITY	Development of obesity in transgenic rats with low circulating growth_hormone levels : involvement of leptin resistance .
11053487	0	leptin	29,35	growth_hormone	11,25	leptin	growth hormone	3952	2688	Gene	Gene	metabolism|compound|START_ENTITY Effects|nmod|metabolism Effects|nmod|END_ENTITY	Effects of growth_hormone on leptin metabolism and energy expenditure in hemodialysis patients with protein-calorie_malnutrition .
11322504	0	leptin	23,29	growth_hormone	33,47	leptin	growth hormone	3952	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	The in vitro effect of leptin on growth_hormone secretion from primary cultured ovine somatotrophs .
11720898	0	leptin	10,16	growth_hormone	99,113	leptin	growth hormone	3952	2688	Gene	Gene	necrosis|nsubj|START_ENTITY necrosis|nmod|treatment treatment|amod|END_ENTITY	Increased leptin and tumour necrosis factor alpha per unit fat mass in hypopituitary women without growth_hormone treatment .
12519870	0	leptin	92,98	growth_hormone	18,32	leptin	growth hormone	3952	2688	Gene	Gene	levels|compound|START_ENTITY mediated|nmod|levels mediated|nsubjpass|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	The inhibition of growth_hormone secretion presented in obesity is not mediated by the high leptin levels : a study in human leptin_deficiency patients .
12721156	0	leptin	20,26	growth_hormone	72,86	leptin	growth hormone	3952	2688	Gene	Gene	dynamics|amod|START_ENTITY Characterization|nmod|dynamics Characterization|nmod|mass mass|appos|END_ENTITY	Characterization of leptin pulse dynamics and relationship to fat mass , growth_hormone , cortisol , and insulin .
15830113	0	leptin	11,17	growth_hormone	21,35	leptin	growth hormone	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	-LSB- Effect of leptin on growth_hormone secretion and apoptosis of GH3 cells -RSB- .
16626817	0	leptin	107,113	growth_hormone	56,70	leptin	growth hormone	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Effects of central infusion and immunoneutralization of growth_hormone on the timing of puberty and plasma leptin levels in the female rat .
17204837	0	leptin	87,93	growth_hormone	11,25	leptin	growth hormone	3952	2688	Gene	Gene	ghrelin|appos|START_ENTITY Effects|dep|ghrelin Effects|nmod|END_ENTITY	Effects of growth_hormone on growth , insulin resistance and related hormones -LRB- ghrelin , leptin and adiponectin -RRB- in Turner_syndrome .
19297186	0	leptin	21,27	growth_hormone	31,45	leptin	growth hormone	25608(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Inhibitory effect of leptin on growth_hormone secretion of GH3 cells : involvement of cell proliferation , apoptosis and intracellular free Ca2 + .
19596030	0	leptin	53,59	growth_hormone	23,37	leptin	growth hormone	3952	2688	Gene	Gene	replacement|nmod|START_ENTITY replacement|compound|END_ENTITY	Influence of long-term growth_hormone replacement on leptin and ghrelin in GH_deficiency before and after glucose load .
22093818	0	leptin	60,66	growth_hormone	44,58	leptin	growth hormone	3952	2688	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	A higher response of plasma neuropeptide_Y , growth_hormone , leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose_tissue to Acipimox during exercise in patients with bulimia_nervosa : single-blind , randomized , microdialysis study .
9025709	0	leptin	58,64	growth_hormone	34,48	leptin	growth hormone	3952	2688	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|nmod|concentrations	Effects of glucocorticoids and of growth_hormone on serum leptin concentrations in man .
9039344	0	leptin	50,56	growth_hormone	9,23	leptin	growth hormone	3952	2688	Gene	Gene	lowers|dobj|START_ENTITY lowers|nsubj|replacement replacement|compound|END_ENTITY	Low-dose growth_hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth_hormone_deficiency .
9302388	0	leptin	55,61	growth_hormone	21,35	leptin	growth hormone	3952	2688	Gene	Gene	status|appos|START_ENTITY status|amod|END_ENTITY	Relationship between growth_hormone -LRB- GH -RRB- status , serum leptin and body composition in healthy and GH_deficient elderly subjects .
9368507	0	leptin	6,12	growth_hormone	104,118	leptin	growth hormone	3952	2688	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|response response|nmod|treatment treatment|amod|END_ENTITY	Serum leptin in short children born small for gestational age : relationship with the growth response to growth_hormone treatment .
9691208	0	leptin	6,12	growth_hormone	30,44	leptin	growth hormone	3952	2688	Gene	Gene	suppressed|nsubjpass|START_ENTITY suppressed|nmod|therapy therapy|amod|END_ENTITY	Serum leptin is suppressed by growth_hormone therapy in growth_hormone-deficient children .
9713555	0	leptin	24,30	growth_hormone	47,61	leptin	growth hormone	3952	2688	Gene	Gene	rhythm|nmod|START_ENTITY preserved|nsubjpass|rhythm preserved|nmod|deficient_hypopituitary_adults deficient_hypopituitary_adults|amod|END_ENTITY	The circadian rhythm of leptin is preserved in growth_hormone deficient_hypopituitary_adults .
9734619	0	leptin	6,12	growth_hormone	64,78	leptin	growth hormone	3952	2688	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Acute leptin regulation in end-stage_renal_failure : the role of growth_hormone and IGF-1 .
9768649	0	leptin	57,63	growth_hormone	10,24	leptin	growth hormone	3952	2688	Gene	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	Effect of growth_hormone -LRB- GH -RRB- on serum concentrations of leptin : study in patients with acromegaly and GH_deficiency .
9829605	0	leptin	7,13	growth_hormone	78,92	leptin	growth hormone	3952	2688	Gene	Gene	levels|compound|START_ENTITY levels|dep|effect effect|nmod|END_ENTITY	Plasma leptin levels in trauma patients : effect of adjuvant recombinant human growth_hormone in intravenously fed multiple trauma patients .
9867083	0	leptin	24,30	growth_hormone	45,59	leptin	growth hormone	3952	2688	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Serum leptin levels and leptin expression in growth_hormone -LRB- GH -RRB- - deficient and healthy adults : influence of GH treatment , gender , and fasting .
18758711	0	leptin	130,136	growth_hormone_receptor	54,77	leptin	growth hormone receptor	396832(Tax:9823)	397488(Tax:9823)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant growth hormone on expression of growth_hormone_receptor , insulin-like growth factor mRNA and serum level of leptin in growing pigs .
23251447	0	leptin	35,41	huntingtin	21,31	leptin	huntingtin	16846(Tax:10090)	15194(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Expression of mutant huntingtin in leptin receptor-expressing neurons does not control the metabolic and psychiatric phenotype of the BACHD mouse .
17591803	0	leptin	34,40	hypoxia-inducible_factor-1_alpha	74,106	leptin	hypoxia-inducible factor-1 alpha	3952	3091	Gene	Gene	Expression|nmod|START_ENTITY correlates|nsubj|Expression correlates|nmod|END_ENTITY	Expression of the obesity hormone leptin and its receptor correlates with hypoxia-inducible_factor-1_alpha in human colorectal_cancer .
10077355	0	leptin	40,46	insulin	50,57	leptin	insulin	3952	3630	Gene	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of free and specifically bound leptin to insulin secretion in patients with impaired_glucose_tolerance -LRB- IGT -RRB- .
10720074	0	leptin	64,70	insulin	31,38	leptin	insulin	3952	3630	Gene	Gene	secretion|compound|START_ENTITY determinant|nmod|secretion determinant|nsubj|metabolism metabolism|nmod|END_ENTITY	Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans .
10778875	0	leptin	29,35	insulin	96,103	leptin	insulin	3952	3630	Gene	Gene	concentrations|compound|START_ENTITY fasting|dobj|concentrations fasting|nmod|subjects subjects|nmod|END_ENTITY	Comparison of fasting plasma leptin concentrations in healthy subjects with high and low plasma insulin .
10778883	0	leptin	62,68	insulin	7,14	leptin	insulin	3952	3630	Gene	Gene	concentration|compound|START_ENTITY linked|nmod|concentration linked|nsubjpass|concentration concentration|compound|END_ENTITY	Plasma insulin concentration is more tightly linked to plasma leptin concentration than is the body mass index .
10856891	0	leptin	138,144	insulin	12,19	leptin	insulin	443534(Tax:9940)	105613195	Gene	Gene	ELISA|compound|START_ENTITY development|nmod|ELISA effects|dep|development have|dobj|effects have|nsubj|END_ENTITY	Adrenaline , insulin and glucagon do not have acute effects on plasma leptin levels in sheep : development and characterisation of an ovine leptin ELISA .
10856891	0	leptin	69,75	insulin	12,19	leptin	insulin	443534(Tax:9940)	105613195	Gene	Gene	levels|compound|START_ENTITY effects|nmod|levels have|dobj|effects have|nsubj|END_ENTITY	Adrenaline , insulin and glucagon do not have acute effects on plasma leptin levels in sheep : development and characterisation of an ovine leptin ELISA .
11036882	0	leptin	27,33	insulin	16,23	leptin	insulin	3952	3630	Gene	Gene	maintenance|compound|START_ENTITY END_ENTITY|nmod|maintenance	Crucial role of insulin in leptin maintenance : profound decrease in serum leptin by octreotide_acetate in insulinoma subjects .
11036882	0	leptin	74,80	insulin	16,23	leptin	insulin	3952	3630	Gene	Gene	decrease|nmod|START_ENTITY role|dep|decrease role|nmod|END_ENTITY	Crucial role of insulin in leptin maintenance : profound decrease in serum leptin by octreotide_acetate in insulinoma subjects .
11074239	0	leptin	6,12	insulin	71,78	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY levels|dep|relation relation|nmod|levels levels|compound|END_ENTITY	Serum leptin levels in type 1 diabetic_and_obese children : relation to insulin levels .
11095459	0	leptin	40,46	insulin	8,15	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY influence|dobj|levels influence|nsubj|levels levels|compound|END_ENTITY	Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity : evidence from both a cross-sectional and an intervention study .
11150869	0	leptin	16,22	insulin	56,63	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY plasma|dobj|levels plasma|nmod|END_ENTITY	Maternal plasma leptin levels and their relationship to insulin and glucose in gestational-onset diabetes .
11231983	0	leptin	33,39	insulin	95,102	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY circulating|dobj|levels patterns|acl|circulating patterns|dep|relationships relationships|nmod|END_ENTITY	Temporal patterns of circulating leptin levels in lean and obese adolescents : relationships to insulin , growth hormone , and free fatty_acids rhythmicity .
11318790	0	leptin	46,52	insulin	11,18	leptin	insulin	3952	3630	Gene	Gene	system|compound|START_ENTITY Effects|nmod|system Effects|nmod|END_ENTITY	Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin .
11318790	0	leptin	86,92	insulin	11,18	leptin	insulin	3952	3630	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Effects Effects|nmod|END_ENTITY	Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin .
11967223	0	leptin	38,44	insulin	63,70	leptin	insulin	280836(Tax:9913)	280829(Tax:9913)	Gene	Gene	infusion|nmod|START_ENTITY normalizes|nsubj|infusion normalizes|dobj|END_ENTITY	Central infusion of recombinant ovine leptin normalizes plasma insulin and stimulates a novel hypersecretion of luteinizing hormone after short-term fasting in mature beef cows .
12039705	0	leptin	54,60	insulin	11,18	leptin	insulin	3952	3630	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|pulse pulse|nmod|END_ENTITY	A pulse of insulin and dexamethasone stimulates serum leptin in fasting human subjects .
12075578	0	leptin	63,69	insulin	37,44	leptin	insulin	3952	3630	Gene	Gene	response|compound|START_ENTITY induced|nmod|response induced|dobj|resistance resistance|compound|END_ENTITY	The effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemia .
12881203	0	leptin	47,53	insulin	10,17	leptin	insulin	280836(Tax:9913)	280829(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|hormone hormone|compound|END_ENTITY	Effect of insulin and growth hormone on plasma leptin in periparturient dairy cows .
12895305	0	leptin	17,23	insulin	57,64	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY plasma|dobj|levels plasma|nmod|END_ENTITY	-LSB- Maternal plasma leptin levels and their relationship to insulin and glucose in pregnant women with gestational_diabetes_mellitus and gestational_impaired_glucose_tolerance -RSB- .
12920661	0	leptin	36,42	insulin	10,17	leptin	insulin	3952	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|therapy therapy|compound|END_ENTITY	Effect of insulin therapy on plasma leptin and body weight in patients with type 2 diabetes .
14655846	0	leptin	7,13	insulin	22,29	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY levels|appos|secretion secretion|compound|END_ENTITY	Plasma leptin levels , insulin secretion , clearance and action on glucose metabolism in anorexia_nervosa .
14993909	0	leptin	7,13	insulin	33,40	leptin	insulin	3952	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|independent independent|compound|END_ENTITY	Plasma leptin is associated with insulin resistance independent of age , body mass index , fat mass , lipids , and pubertal development in nondiabetic adolescents .
18521457	0	leptin	15,21	insulin	27,34	leptin	insulin	3952	3630	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|resistance resistance|compound|END_ENTITY	Association of leptin with insulin resistance , body composition , and lipid parameters in postmenopausal women and men in type_2_diabetes_mellitus .
18726828	0	leptin	180,186	insulin	17,24	leptin	insulin	3952	3630	Gene	Gene	treatment|amod|START_ENTITY homeostasis|nmod|treatment course|nmod|homeostasis Deconvolution|dep|course Deconvolution|nmod|rates rates|compound|END_ENTITY	Deconvolution of insulin secretion , insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals : time course of glucose homeostasis in leptin replacement treatment .
18726828	0	leptin	180,186	insulin	36,43	leptin	insulin	3952	3630	Gene	Gene	treatment|amod|START_ENTITY homeostasis|nmod|treatment course|nmod|homeostasis Deconvolution|dep|course Deconvolution|nmod|rates rates|compound|END_ENTITY	Deconvolution of insulin secretion , insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals : time course of glucose homeostasis in leptin replacement treatment .
19419266	0	leptin	21,27	insulin	79,86	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|resistance resistance|compound|END_ENTITY	Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic_syndrome : the key role of central_obesity .
19579977	0	leptin	17,23	insulin	68,75	leptin	insulin	3952	3630	Gene	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Circulation free leptin in diabetic patients and its correlation to insulin level .
20484473	0	leptin	15,21	insulin	54,61	leptin	insulin	3952	3630	Gene	Gene	level|compound|START_ENTITY measure|nsubj|level measure|nmod|sensitivity sensitivity|compound|END_ENTITY	Fasting plasma leptin level is a surrogate measure of insulin sensitivity .
21411512	0	leptin	18,24	insulin	52,59	leptin	insulin	3952	3630	Gene	Gene	treatment|compound|START_ENTITY improve|nsubj|treatment improve|dobj|action action|compound|END_ENTITY	Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes .
23266767	0	leptin	8,14	insulin	34,41	leptin	insulin	3952	3630	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|resistance resistance|compound|END_ENTITY	Role of leptin and adiponectin in insulin resistance .
23565488	0	leptin	15,21	insulin	35,42	leptin	insulin	3952	3630	Gene	Gene	Stimulation|nmod|START_ENTITY secretion|nsubj|Stimulation secretion|nmod|END_ENTITY	Stimulation of leptin secretion by insulin .
23919188	0	leptin	6,12	insulin	88,95	leptin	insulin	3952	3630	Gene	Gene	level|compound|START_ENTITY level|dep|correlation correlation|nmod|END_ENTITY	Serum leptin level in women with polycystic_ovary_syndrome : correlation with adiposity , insulin , and circulating testosterone .
24251168	0	leptin	7,13	insulin	22,29	leptin	insulin	3952	3630	Gene	Gene	replace|nsubj|START_ENTITY replace|dobj|END_ENTITY	Should leptin replace insulin as a lifetime monotherapy for diabetes_type_1_and_2 ?
25870537	0	leptin	36,42	insulin	15,22	leptin	insulin	3952	3630	Gene	Gene	role|nmod|START_ENTITY role|dep|Living Living|nmod|END_ENTITY	Living without insulin : the role of leptin signaling in the hypothalamus .
25995751	0	leptin	6,12	insulin	73,80	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|resistance resistance|compound|END_ENTITY	Serum leptin levels in gastric_cancer patients and the relationship with insulin resistance .
25995751	0	leptin	6,12	insulin	73,80	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY levels|nmod|resistance resistance|compound|END_ENTITY	Serum leptin levels in gastric_cancer patients and the relationship with insulin resistance .
8621027	0	leptin	40,46	insulin	29,36	leptin	insulin	3952	3630	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Acute and chronic effects of insulin on leptin production in humans : Studies in vivo and in vitro .
8954054	0	leptin	52,58	insulin	87,94	leptin	insulin	3952	3630	Gene	Gene	START_ENTITY|nmod|changes changes|nmod|sensitivity sensitivity|compound|END_ENTITY	Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women .
9130025	0	leptin	6,12	insulin	72,79	leptin	insulin	3952	3630	Gene	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Serum leptin in subjects with impaired_glucose_tolerance in relation to insulin sensitivity and first-phase insulin response .
9177365	0	leptin	6,12	insulin	73,80	leptin	insulin	3952	3630	Gene	Gene	levels|compound|START_ENTITY levels|dep|role role|nmod|resistance/hyperinsulinemia resistance/hyperinsulinemia|compound|END_ENTITY	Serum leptin levels in women with polycystic_ovary_syndrome : the role of insulin resistance/hyperinsulinemia .
9249764	0	leptin	6,12	insulin	48,55	leptin	insulin	3952	3630	Gene	Gene	concentrations|compound|START_ENTITY correlate|nsubj|concentrations correlate|xcomp|plasma plasma|xcomp|independent independent|nsubj|concentrations concentrations|compound|END_ENTITY	Serum leptin concentrations correlate to plasma insulin concentrations independent of body fat content in chronic_renal_failure .
9283792	0	leptin	43,49	insulin	88,95	leptin	insulin	3952	3630	Gene	Gene	concentrations|compound|START_ENTITY parallel|nsubj|concentrations parallel|nmod|changes changes|nmod|END_ENTITY	Glibenclamide , but not acarbose , increases leptin concentrations parallel to changes in insulin in subjects with NIDDM .
9588462	0	leptin	28,34	insulin	78,85	leptin	insulin	3952	3630	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|dep|role role|nmod|END_ENTITY	Overexpression of placental leptin in diabetic_pregnancy : a critical role for insulin .
9591754	0	leptin	19,25	insulin	85,92	leptin	insulin	3952	3630	Gene	Gene	Increase|nmod|START_ENTITY dependent|csubj|Increase dependent|nmod|END_ENTITY	Increase in plasma leptin and Lep mRNA concentrations by food intake is dependent on insulin .
12140788	0	leptin	38,44	leptin	57,63	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum .
12140788	0	leptin	57,63	leptin	38,44	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum .
12372004	0	leptin	36,42	leptin	69,75	leptin	leptin	25608(Tax:10116)	25608(Tax:10116)	Gene	Gene	START_ENTITY|nmod|infusion infusion|compound|END_ENTITY	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
12372004	0	leptin	69,75	leptin	36,42	leptin	leptin	25608(Tax:10116)	25608(Tax:10116)	Gene	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
12559213	0	leptin	25,31	leptin	44,50	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic_heart_failure .
12559213	0	leptin	44,50	leptin	25,31	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic_heart_failure .
14575895	0	leptin	40,46	leptin	61,67	leptin	leptin	25608(Tax:10116)	25608(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat .
14575895	0	leptin	61,67	leptin	40,46	leptin	leptin	25608(Tax:10116)	25608(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Effect of nicotine on the expression of leptin and forebrain leptin receptors in the rat .
15144331	0	leptin	20,26	leptin	78,84	leptin	leptin	3952	3952	Gene	Gene	levels|compound|START_ENTITY levels|dep|relation relation|nmod|levels levels|compound|END_ENTITY	Cerebrospinal fluid leptin levels in preeclampsia : relation to maternal serum leptin levels .
15144331	0	leptin	78,84	leptin	20,26	leptin	leptin	3952	3952	Gene	Gene	levels|compound|START_ENTITY relation|nmod|levels levels|dep|relation levels|compound|END_ENTITY	Cerebrospinal fluid leptin levels in preeclampsia : relation to maternal serum leptin levels .
16093869	0	leptin	22,28	leptin	6,12	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Serum leptin , soluble leptin receptor , free leptin index and bone_mineral_density in patients with primary_biliary_cirrhosis .
16093869	0	leptin	6,12	leptin	22,28	leptin	leptin	3952	3952	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Serum leptin , soluble leptin receptor , free leptin index and bone_mineral_density in patients with primary_biliary_cirrhosis .
16782141	0	leptin	12,18	leptin	22,28	leptin	leptin	3952	3952	Gene	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	The role of leptin in leptin resistance and obesity .
16782141	0	leptin	22,28	leptin	12,18	leptin	leptin	3952	3952	Gene	Gene	resistance|compound|START_ENTITY role|nmod|resistance role|nmod|END_ENTITY	The role of leptin in leptin resistance and obesity .
18473416	0	leptin	25,31	leptin	6,12	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Serum leptin and soluble leptin receptor in non-alcoholic_fatty_liver_disease .
18473416	0	leptin	6,12	leptin	25,31	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Serum leptin and soluble leptin receptor in non-alcoholic_fatty_liver_disease .
18637894	0	leptin	26,32	leptin	6,12	leptin	leptin	3952	3952	Gene	Gene	levels|appos|START_ENTITY levels|compound|END_ENTITY	Serum leptin levels , skin leptin and leptin_receptor expression in psoriasis .
18637894	0	leptin	6,12	leptin	26,32	leptin	leptin	3952	3952	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum leptin levels , skin leptin and leptin_receptor expression in psoriasis .
20422702	0	leptin	14,20	leptin	47,53	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|dep|END_ENTITY	Expression of leptin receptor in nasal_polyps : leptin as a mucosecretagogue .
20422702	0	leptin	47,53	leptin	14,20	leptin	leptin	3952	3952	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of leptin receptor in nasal_polyps : leptin as a mucosecretagogue .
21347230	0	leptin	78,84	leptin	97,103	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Effects of body fat on the associations of high-molecular-weight adiponectin , leptin and soluble leptin receptor with metabolic_syndrome in Chinese .
21347230	0	leptin	97,103	leptin	78,84	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Effects of body fat on the associations of high-molecular-weight adiponectin , leptin and soluble leptin receptor with metabolic_syndrome in Chinese .
21631924	0	leptin	17,23	leptin	36,42	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18 G _ > _ A and leptin receptor genes K109R and Q223R , in survivors of childhood acute_lymphoblastic_leukemia .
21631924	0	leptin	36,42	leptin	17,23	leptin	leptin	3952	3952	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18 G _ > _ A and leptin receptor genes K109R and Q223R , in survivors of childhood acute_lymphoblastic_leukemia .
23026132	0	leptin	102,108	leptin	79,85	leptin	leptin	3952	3952	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene , decreased leptin mRNA expression , and decreased leptin serum levels .
23026132	0	leptin	79,85	leptin	102,108	leptin	leptin	3952	3952	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene , decreased leptin mRNA expression , and decreased leptin serum levels .
23287761	0	leptin	103,109	leptin	21,27	leptin	leptin	16846(Tax:10090)	16846(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The temporal role of leptin within fracture healing and the effect of local application of recombinant leptin on fracture healing .
23287761	0	leptin	21,27	leptin	103,109	leptin	leptin	16846(Tax:10090)	16846(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The temporal role of leptin within fracture healing and the effect of local application of recombinant leptin on fracture healing .
24703965	0	leptin	16,22	leptin	35,41	leptin	leptin	3952	3952	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children .
24703965	0	leptin	35,41	leptin	16,22	leptin	leptin	3952	3952	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	The relation of leptin and soluble leptin receptor levels with metabolic and clinical parameters in obese and healthy children .
9288733	0	leptin	32,38	leptin	40,46	leptin	leptin	3952	3952	Gene	Gene	production|nmod|START_ENTITY production|dep|END_ENTITY	Nonadipose tissue production of leptin : leptin as a novel placenta-derived hormone in humans .
9288733	0	leptin	40,46	leptin	32,38	leptin	leptin	3952	3952	Gene	Gene	production|dep|START_ENTITY production|nmod|END_ENTITY	Nonadipose tissue production of leptin : leptin as a novel placenta-derived hormone in humans .
11479137	0	leptin	24,30	leptin_receptor	141,156	leptin	leptin receptor	25608(Tax:10116)	24536(Tax:10116)	Gene	Gene	action|compound|START_ENTITY mechanisms|nmod|action mechanisms|dep|targets targets|nmod|expression expression|amod|END_ENTITY	Molecular mechanisms of leptin action in adult rat testis : potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin_receptor messenger ribonucleic acid expression .
15081545	0	leptin	5,11	leptin_receptor	53,68	leptin	leptin receptor	16846(Tax:10090)	16847(Tax:10090)	Gene	Gene	level|compound|START_ENTITY accompanied|nsubjpass|level accompanied|nmod|transcript transcript|compound|END_ENTITY	High leptin level is accompanied with decreased long leptin_receptor transcript in histamine deficient transgenic_mice .
15491384	0	leptin	11,17	leptin_receptor	54,69	leptin	leptin receptor	3952	3953	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|mRNA mRNA|compound|END_ENTITY	Effects of leptin and dexamethasone on long and short leptin_receptor mRNA .
17638985	0	leptin	22,28	leptin_receptor	47,62	leptin	leptin receptor	280836(Tax:9913)	497205(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|transcripts transcripts|compound|END_ENTITY	Effect of estrogen on leptin and expression of leptin_receptor transcripts in prepubertal dairy heifers .
22545089	0	leptin	92,98	leptin_receptor	58,73	leptin	leptin receptor	3952	3953	Gene	Gene	action|compound|START_ENTITY implications|nmod|action mechanisms|dep|implications mechanisms|nmod|generation generation|nmod|END_ENTITY	Novel regulatory mechanisms for generation of the soluble leptin_receptor : implications for leptin action .
23266707	0	leptin	63,69	leptin_receptor	26,41	leptin	leptin receptor	3952	3953	Gene	Gene	changes|compound|START_ENTITY related|nmod|changes related|nsubjpass|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Lys656Asn polymorphism of leptin_receptor gene is related with leptin changes after a high monounsaturated fat diet in obese patients .
24401660	0	leptin	118,124	leptin_receptor	28,43	leptin	leptin receptor	3952	3953	Gene	Gene	levels|nmod|START_ENTITY endometrioma|nmod|levels affected|nmod|endometrioma affected|nsubj|expression expression|nmod|END_ENTITY	Increased expression of the leptin_receptor in human ovaries affected by endometrioma and detection of high levels of leptin in the ovarian endometriomal fluid .
26123401	0	leptin	28,34	leptin_receptor	36,51	leptin	leptin receptor	3952	3953	Gene	Gene	association|nmod|START_ENTITY Lack|nmod|association Lack|appos|END_ENTITY	Lack of association between leptin , leptin_receptor , adiponectin gene polymorphisms and epicardial adipose tissue , abdominal visceral fat volume and atherosclerotic_burden in psoriasis patients .
9061609	0	leptin	84,90	leptin_receptor	40,55	leptin	leptin receptor	3952	3953	Gene	Gene	immunoadhesin|compound|START_ENTITY using|dobj|immunoadhesin Cloning|acl|using Cloning|nmod|END_ENTITY	Cloning and characterization of a human leptin_receptor using a biologically active leptin immunoadhesin .
9388507	0	leptin	62,68	leptin_receptor	4,19	leptin	leptin receptor	25608(Tax:10116)	24536(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression mediates|dobj|regulation mediates|nsubj|END_ENTITY	The leptin_receptor mediates apparent autocrine regulation of leptin gene expression .
9988112	0	leptin	39,45	leptin_receptor	14,29	leptin	leptin receptor	3952	3953	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of leptin_receptor in lung : leptin as a growth factor .
12372004	0	leptin	123,129	neuropeptide_Y	144,158	leptin	neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	resistance|compound|START_ENTITY development|nmod|resistance associated|nmod|development associated|nmod|neurones neurones|amod|END_ENTITY	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
12372004	0	leptin	36,42	neuropeptide_Y	144,158	leptin	neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	action|nmod|START_ENTITY Resistance|nmod|action associated|nsubjpass|Resistance associated|nmod|neurones neurones|amod|END_ENTITY	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
12372004	0	leptin	69,75	neuropeptide_Y	144,158	leptin	neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	infusion|compound|START_ENTITY leptin|nmod|infusion action|nmod|leptin Resistance|nmod|action associated|nsubjpass|Resistance associated|nmod|neurones neurones|amod|END_ENTITY	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
16006740	0	leptin	134,140	neuropeptide_Y	111,125	leptin	neuropeptide Y	16846(Tax:10090)	109648(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of neuronal genes and its effect on neural functions : transcriptional regulation of neuropeptide_Y gene by leptin and its effect on feeding .
16135994	0	leptin	27,33	neuropeptide_Y	35,49	leptin	neuropeptide Y	3952	4852	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Plasma orexin A , orexin B , leptin , neuropeptide_Y -LRB- NPY -RRB- and insulin in obese women .
22093818	0	leptin	60,66	neuropeptide_Y	28,42	leptin	neuropeptide Y	3952	4852	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	A higher response of plasma neuropeptide_Y , growth_hormone , leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose_tissue to Acipimox during exercise in patients with bulimia_nervosa : single-blind , randomized , microdialysis study .
22645062	0	leptin	7,13	neuropeptide_Y	15,29	leptin	neuropeptide Y	3952	4852	Gene	Gene	thickness|nsubj|START_ENTITY thickness|advmod|END_ENTITY	Plasma leptin , neuropeptide_Y , ghrelin , and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate .
23652383	0	leptin	95,101	neuropeptide_Y	31,45	leptin	neuropeptide Y	3952	4852	Gene	Gene	levels|compound|START_ENTITY associated|nmod|levels associated|nsubjpass|polymorphism polymorphism|nmod|promoter promoter|amod|END_ENTITY	Functional polymorphism in the neuropeptide_Y gene promoter -LRB- rs16147 -RRB- is associated with serum leptin levels and waist-hip ratio in women .
9688683	0	leptin	15,21	neuropeptide_Y	35,49	leptin	neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	site|nmod|START_ENTITY influence|nsubj|site influence|advcl|signaling signaling|advmod|END_ENTITY	Neural site of leptin influence on neuropeptide_Y signaling pathways altering feeding and uncoupling protein .
9725806	0	leptin	32,38	neuropeptide_Y	56,70	leptin	neuropeptide Y	25608(Tax:10116)	24604(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Aging and fasting regulation of leptin and hypothalamic neuropeptide_Y gene expression .
17332528	0	leptin	160,166	proopiomelanocortin	119,138	leptin	proopiomelanocortin	3952	5443	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Glucose regulates AMP-activated protein kinase activity and gene expression in clonal , hypothalamic neurons expressing proopiomelanocortin : additive effects of leptin or insulin .
14764629	0	leptin	112,118	signal_transducer_and_activator_of_transcription_3	8,58	leptin	signal transducer and activator of transcription 3	25608(Tax:10116)	25125(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_3 in regulation of hypothalamic trh gene expression by leptin .
17082312	0	leptin	162,168	signal_transducer_and_activator_of_transcription_3	64,114	leptin	signal transducer and activator of transcription 3	25608(Tax:10116)	25125(Tax:10116)	Gene	Gene	resistance|compound|START_ENTITY reveals|nmod|resistance reveals|dobj|uncoupling uncoupling|nmod|responses responses|compound|signaling signaling|amod|END_ENTITY	Leptin antagonist reveals an uncoupling between leptin receptor signal_transducer_and_activator_of_transcription_3 signaling and metabolic responses with central leptin resistance .
17082312	0	leptin	48,54	signal_transducer_and_activator_of_transcription_3	64,114	leptin	signal transducer and activator of transcription 3	25608(Tax:10116)	25125(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Leptin antagonist reveals an uncoupling between leptin receptor signal_transducer_and_activator_of_transcription_3 signaling and metabolic responses with central leptin resistance .
18096691	0	leptin	87,93	signal_transducer_and_activator_of_transcription_3	33,83	leptin	signal transducer and activator of transcription 3	16846(Tax:10090)	20848(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY roles|nmod|neurons roles|nmod|END_ENTITY	Specific physiological roles for signal_transducer_and_activator_of_transcription_3 in leptin receptor-expressing neurons .
21163886	0	leptin	52,58	signal_transducer_and_activator_of_transcription_3	117,167	leptin	signal transducer and activator of transcription 3	3952	6774	Gene	Gene	actions|nmod|START_ENTITY inhibits|dobj|actions inhibits|advcl|suppressing suppressing|dobj|activation activation|nmod|END_ENTITY	Benzyl_isothiocyanate inhibits oncogenic actions of leptin in human breast_cancer cells by suppressing activation of signal_transducer_and_activator_of_transcription_3 .
11134186	0	leptin	72,78	thyrotropin-releasing_hormone	34,63	leptin	thyrotropin-releasing hormone	25608(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the thyrotropin-releasing_hormone gene by leptin and melanocortin signaling .
10526261	0	leptin	26,32	tumor_necrosis_factor-alpha	107,134	leptin	tumor necrosis factor-alpha	3952	7124	Gene	Gene	release|nmod|START_ENTITY release|dep|effect effect|nmod|END_ENTITY	Depot-specific release of leptin from subcutaneous and omental adipocytes in suspension culture : effect of tumor_necrosis_factor-alpha and transforming_growth_factor-beta1 .
11758007	0	leptin	32,38	tumor_necrosis_factor-alpha	65,92	leptin	tumor necrosis factor-alpha	3952	7124	Gene	Gene	receptors|amod|START_ENTITY circulating|dobj|receptors circulating|nmod|END_ENTITY	Association between circulating leptin and soluble receptors for tumor_necrosis_factor-alpha in hemodialysis patients .
11959686	0	leptin	50,56	tumor_necrosis_factor-alpha	60,87	leptin	tumor necrosis factor-alpha	16846(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY inhibit|dobj|induction inhibit|nmod|END_ENTITY	Anti-inflammatory agents inhibit the induction of leptin by tumor_necrosis_factor-alpha .
21274300	0	leptin	73,79	tumor_necrosis_factor-alpha	44,71	leptin	tumor necrosis factor-alpha	3952	7124	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
10490793	0	leptin	42,48	tumor_necrosis_factor_alpha	11,38	leptin	tumor necrosis factor alpha	25608(Tax:10116)	24835(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effects of tumor_necrosis_factor_alpha on leptin secretion and gene expression : relationship to changes of glucose metabolism in isolated rat adipocytes .
9529118	0	leptin	10,16	tumor_necrosis_factor_alpha	89,116	leptin	tumor necrosis factor alpha	16846(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Increased leptin expression in mice with bacterial_peritonitis is partially regulated by tumor_necrosis_factor_alpha .
9177227	0	leptin	13,19	uncoupling_protein-2	23,43	leptin	uncoupling protein-2	25608(Tax:10116)	54315(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction by leptin of uncoupling_protein-2 and enzymes of fatty_acid oxidation .
17884030	0	leptin	41,47	visfatin	59,67	leptin	visfatin	3952	10135	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	Relationships between serum adiponectin , leptin , resistin , visfatin levels and bone mineral density , and bone biochemical markers in Chinese men .
19389835	0	leptin	57,63	visfatin	34,42	leptin	visfatin	3952	10135	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose_tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways .
21738955	0	leptin	18,24	visfatin	66,74	leptin	visfatin	3952	10135	Gene	Gene	adiponectin|compound|START_ENTITY adipokines|compound|adiponectin role|nmod|adipokines role|dep|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
21738955	0	leptin	18,24	visfatin	66,74	leptin	visfatin	3952	10135	Gene	Gene	adiponectin|compound|START_ENTITY adipokines|compound|adiponectin role|nmod|adipokines role|dep|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
15240518	0	leptin_and_leptin_receptor	23,49	OB-R	51,55	leptin and leptin receptor	OB-R	3952;3953	3953	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of leptin_and_leptin_receptor -LRB- OB-R -RRB- in human breast_cancer .
17006991	0	leptin_and_leptin_receptor	22,48	OB-R	50,54	leptin and leptin receptor	OB-R	3952;3953	3953	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of leptin_and_leptin_receptor -LRB- OB-R -RRB- in human gastric_cancer .
22076135	0	leptin_receptor	16,31	Erk1/2	0,6	leptin receptor	Erk1/2	24536(Tax:10116)	50689;116590	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Erk1/2 mediates leptin_receptor signaling in the ventral tegmental area .
22028824	0	leptin_receptor	36,51	LEPR	58,62	leptin receptor	LEPR	3953	3953	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between variants of the leptin_receptor gene -LRB- LEPR -RRB- and overweight : a systematic review and an analysis of the CoLaus study .
23090836	0	leptin_receptor	8,23	LEPR	25,29	leptin receptor	LEPR	3953	3953	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Role of leptin_receptor -LRB- LEPR -RRB- gene polymorphisms and haplotypes in susceptibility to hepatocellular_carcinoma in subjects with chronic hepatitis_B_virus infection .
12730408	0	leptin_receptor	4,19	Lepr	39,43	leptin receptor	Lepr	16847(Tax:10090)	16847(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|END_ENTITY	New leptin_receptor mutations in mice : Lepr -LRB- db-rtnd -RRB- , Lepr -LRB- db-dmpg -RRB- and Lepr -LRB- db-rlpy -RRB- .
10329976	0	leptin_receptor	42,57	Leptin	0,6	leptin receptor	Leptin	24536(Tax:10116)	25608(Tax:10116)	Gene	Gene	mutation|compound|START_ENTITY responsiveness|nmod|mutation responsiveness|amod|END_ENTITY	Leptin responsiveness and gene dosage for leptin_receptor mutation -LRB- fa -RRB- in newborn rats .
11092515	0	leptin_receptor	50,65	Leptin	0,6	leptin receptor	Leptin	24536(Tax:10116)	25608(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY associated|nmod|mRNA associated|nsubjpass|resistance resistance|compound|END_ENTITY	Leptin resistance is associated with hypothalamic leptin_receptor mRNA and protein downregulation .
14601735	0	leptin_receptor	32,47	Leptin	0,6	leptin receptor	Leptin	374223(Tax:9031)	373955(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY downregulate|dobj|expression downregulate|nsubj|END_ENTITY	Leptin and insulin downregulate leptin_receptor gene expression in chicken-derived leghorn male hepatoma cells .
17400175	0	leptin_receptor	117,132	Leptin	0,6	leptin receptor	Leptin	16847(Tax:10090)	16846(Tax:10090)	Gene	Gene	form|nmod|START_ENTITY mice|nmod|form attenuates|nmod|mice attenuates|nsubj|END_ENTITY	Leptin attenuates gene expression for renal 25-hydroxyvitamin_D3-1alpha-hydroxylase in mice via the long form of the leptin_receptor .
11159367	0	leptin_receptor	41,56	Ob-R	58,62	leptin receptor	Ob-R	24536(Tax:10116)	24536(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Developmental and hormonal regulation of leptin_receptor -LRB- Ob-R -RRB- messenger ribonucleic acid expression in rat testis .
14527166	0	leptin_receptor	14,29	Ob-R	31,35	leptin receptor	Ob-R	16847(Tax:10090)	16847(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of leptin_receptor -LRB- Ob-R -RRB- isoforms and signal transducers and activators of transcription -LRB- STATs -RRB- mRNAs in the mouse taste buds .
11342028	0	leptin_receptor	77,92	SHP-2	58,63	leptin receptor	SHP-2	3953	5781	Gene	Gene	tyrosine|nmod|START_ENTITY tyrosine|dobj|END_ENTITY	A model of activation of the protein tyrosine phosphatase SHP-2 by the human leptin_receptor .
10080923	0	leptin_receptor	52,67	STAT3	28,33	leptin receptor	STAT3	16847(Tax:10090)	20848(Tax:10090)	Gene	Gene	leptin|nmod|START_ENTITY END_ENTITY|nmod|leptin	Tyrosine phosphorylation of STAT3 by leptin through leptin_receptor in mouse metaphase 2 stage oocyte .
17095713	0	leptin_receptor	116,131	STAT3	132,137	leptin receptor	STAT3	16847(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Leptin regulates neointima formation after arterial_injury through mechanisms independent of blood pressure and the leptin_receptor / STAT3 signaling pathways involved in energy balance .
17202473	0	leptin_receptor	91,106	STAT3	107,112	leptin receptor	STAT3	16847(Tax:10090)	20848(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|parataxis|signaling signaling|nsubj|END_ENTITY	Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin_receptor / STAT3 signaling .
8895396	0	leptin_receptor	101,116	STAT_1_and_3	11,23	leptin receptor	STAT 1 and 3	24536(Tax:10116)	25124;25125	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Functional STAT_1_and_3 signaling by the leptin_receptor -LRB- OB-R -RRB- ; reduced expression of the rat fatty leptin_receptor in transfected cells .
8895396	0	leptin_receptor	41,56	STAT_1_and_3	11,23	leptin receptor	STAT 1 and 3	24536(Tax:10116)	25124;25125	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Functional STAT_1_and_3 signaling by the leptin_receptor -LRB- OB-R -RRB- ; reduced expression of the rat fatty leptin_receptor in transfected cells .
21672929	0	leptin_receptor	54,69	Sam68	0,5	leptin receptor	Sam68	3953	10657	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Sam68 mediates leptin-stimulated growth by modulating leptin_receptor signaling in human trophoblastic JEG-3 cells .
9868173	0	leptin_receptor	54,69	fak	76,79	leptin receptor	fak	24536(Tax:10116)	25614(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phenotypic consequences of a nonsense mutation in the leptin_receptor gene -LRB- fak -RRB- in obese spontaneously hypertensive Koletsky rats -LRB- SHROB -RRB- .
9092791	0	leptin_receptor	4,19	janus_kinase_2	30,44	leptin receptor	janus kinase 2	16847(Tax:10090)	16452(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The leptin_receptor activates janus_kinase_2 and signals for proliferation in a factor-dependent cell line .
11479137	0	leptin_receptor	141,156	leptin	24,30	leptin receptor	leptin	24536(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY targets|nmod|expression mechanisms|dep|targets mechanisms|nmod|action action|compound|END_ENTITY	Molecular mechanisms of leptin action in adult rat testis : potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin_receptor messenger ribonucleic acid expression .
15081545	0	leptin_receptor	53,68	leptin	5,11	leptin receptor	leptin	16847(Tax:10090)	16846(Tax:10090)	Gene	Gene	transcript|compound|START_ENTITY accompanied|nmod|transcript accompanied|nsubjpass|level level|compound|END_ENTITY	High leptin level is accompanied with decreased long leptin_receptor transcript in histamine deficient transgenic_mice .
15491384	0	leptin_receptor	54,69	leptin	11,17	leptin receptor	leptin	3953	3952	Gene	Gene	mRNA|compound|START_ENTITY Effects|nmod|mRNA Effects|nmod|END_ENTITY	Effects of leptin and dexamethasone on long and short leptin_receptor mRNA .
17638985	0	leptin_receptor	47,62	leptin	22,28	leptin receptor	leptin	497205(Tax:9913)	280836(Tax:9913)	Gene	Gene	transcripts|compound|START_ENTITY Effect|nmod|transcripts Effect|nmod|END_ENTITY	Effect of estrogen on leptin and expression of leptin_receptor transcripts in prepubertal dairy heifers .
22545089	0	leptin_receptor	58,73	leptin	92,98	leptin receptor	leptin	3953	3952	Gene	Gene	generation|nmod|START_ENTITY mechanisms|nmod|generation mechanisms|dep|implications implications|nmod|action action|compound|END_ENTITY	Novel regulatory mechanisms for generation of the soluble leptin_receptor : implications for leptin action .
23266707	0	leptin_receptor	26,41	leptin	63,69	leptin receptor	leptin	3953	3952	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene related|nsubjpass|polymorphism related|nmod|changes changes|compound|END_ENTITY	Lys656Asn polymorphism of leptin_receptor gene is related with leptin changes after a high monounsaturated fat diet in obese patients .
24401660	0	leptin_receptor	28,43	leptin	118,124	leptin receptor	leptin	3953	3952	Gene	Gene	expression|nmod|START_ENTITY affected|nsubj|expression affected|nmod|endometrioma endometrioma|nmod|levels levels|nmod|END_ENTITY	Increased expression of the leptin_receptor in human ovaries affected by endometrioma and detection of high levels of leptin in the ovarian endometriomal fluid .
26123401	0	leptin_receptor	36,51	leptin	28,34	leptin receptor	leptin	3953	3952	Gene	Gene	Lack|appos|START_ENTITY Lack|nmod|association association|nmod|END_ENTITY	Lack of association between leptin , leptin_receptor , adiponectin gene polymorphisms and epicardial adipose tissue , abdominal visceral fat volume and atherosclerotic_burden in psoriasis patients .
9061609	0	leptin_receptor	40,55	leptin	84,90	leptin receptor	leptin	3953	3952	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|acl|using using|dobj|immunoadhesin immunoadhesin|compound|END_ENTITY	Cloning and characterization of a human leptin_receptor using a biologically active leptin immunoadhesin .
9388507	0	leptin_receptor	4,19	leptin	62,68	leptin receptor	leptin	24536(Tax:10116)	25608(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|expression expression|amod|END_ENTITY	The leptin_receptor mediates apparent autocrine regulation of leptin gene expression .
9988112	0	leptin_receptor	14,29	leptin	39,45	leptin receptor	leptin	3953	3952	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of leptin_receptor in lung : leptin as a growth factor .
21267512	0	leptin_receptor_long_isoform	15,43	STAT3	52,57	leptin receptor long isoform	STAT3	16847(Tax:10090)	20848(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of leptin_receptor_long_isoform -LRB- LepRb -RRB- - STAT3 signaling pathway in brain fat mass - and obesity-associated -LRB- FTO -RRB- downregulation during energy restriction .
23940039	0	leptin_receptor_overlapping_transcript	154,192	growth_hormone	97,111	leptin receptor overlapping transcript	growth hormone	230514(Tax:10090)	14599(Tax:10090)	Gene	Gene	inducing|dobj|START_ENTITY END_ENTITY|advcl|inducing	Increased expression of fibroblast_growth_factor_21 -LRB- FGF21 -RRB- during chronic undernutrition causes growth_hormone insensitivity in chondrocytes by inducing leptin_receptor_overlapping_transcript -LRB- LEPROT -RRB- and leptin_receptor_overlapping_transcript-like 1 -LRB- LEPROTL1 -RRB- expression .
11342119	0	leptin_receptor_overlapping_transcript-like_1	46,91	LEPROTL1	98,106	leptin receptor overlapping transcript-like 1	LEPROTL1	23484	23484	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a novel human leptin_receptor_overlapping_transcript-like_1 gene -LRB- LEPROTL1 -RRB- .
19473986	0	leptospira_immunoglobulin-like_proteins	20,59	elastin	74,81	leptospira immunoglobulin-like proteins	elastin	3093	2006	Gene	Gene	domains|nmod|START_ENTITY interact|nsubj|domains interact|nmod|END_ENTITY	Repeated domains of leptospira_immunoglobulin-like_proteins interact with elastin and tropoelastin .
19528180	0	leptospiral_immunoglobulin-like	20,51	lig	53,56	leptospiral immunoglobulin-like	lig	3093	3093	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Distribution of the leptospiral_immunoglobulin-like -LRB- lig -RRB- genes in pathogenic Leptospira species and application of ligB to typing leptospiral isolates .
25805859	0	let-7	42,47	LIN-28	21,27	let-7	LIN-28	266952(Tax:6239)	172626(Tax:6239)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. _ elegans .
24776851	0	let-7	17,22	RACK-1	0,6	let-7	RACK-1	266952(Tax:6239)	177895(Tax:6239)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis_elegans .
23974362	0	let-7a1	10,17	insulin-like_growth_factor_1_receptor	45,82	let-7a1	insulin-like growth factor 1 receptor	406881	3480	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	The miRNA let-7a1 inhibits the expression of insulin-like_growth_factor_1_receptor -LRB- IGF1R -RRB- in prostate_cancer PC-3 cells .
25225797	0	let-7b	11,17	EZH2	19,23	let-7b	EZH2	406884	2146	Gene	Gene	START_ENTITY|dep|axis axis|nummod|END_ENTITY	The KDM2B - let-7b - EZH2 axis in myelodysplastic_syndromes as a target for combined epigenetic therapy .
24810113	0	let-7b	20,26	IGF-1R	0,6	let-7b	IGF-1R	406884	3480	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	IGF-1R , a target of let-7b , mediates crosstalk between IRS-2 / Akt and MAPK pathways to promote proliferation of oral_squamous_cell_carcinoma .
18983959	0	let-7b	24,30	Ink4a/Arf	0,9	let-7b	Ink4a/Arf	387245(Tax:10090)	12578(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Ink4a/Arf regulation by let-7b and Hmga2 : a genetic pathway governing stem cell aging .
25744272	0	let-7b	8,14	N-acetylgalactosaminyltransferase_2	36,71	let-7b	N-acetylgalactosaminyltransferase 2	406884	79586	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of let-7b in the regulation of N-acetylgalactosaminyltransferase_2 in IgA_nephropathy .
22917031	0	let-7c	9,15	Bcl-xl	25,31	let-7c	Bcl-xl	406885	598	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis .
23981581	0	let-7c	9,15	ITGB3	97,102	let-7c	ITGB3	406885	3690	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA let-7c inhibits migration and invasion of human non-small_cell_lung_cancer by targeting ITGB3 and MAP4K3 .
22128178	0	let-7c	9,15	androgen_receptor	27,44	let-7c	androgen receptor	406885	367	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	MicroRNA let-7c suppresses androgen_receptor expression and activity via regulation of Myc expression in prostate_cancer cells .
24365598	0	let-7c	46,52	miR-99a	38,45	let-7c	miR-99a	406885	407055	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Cardiomyogenesis is controlled by the miR-99a / let-7c cluster and epigenetic modifications .
26455324	0	let-7c	30,36	miR-99a	37,44	let-7c	miR-99a	406885	407055	Gene	Gene	progression|amod|START_ENTITY progression|dep|END_ENTITY	Genome-wide screen identified let-7c / miR-99a / miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma .
24096609	0	lethal_giant_larvae	16,35	Lgl	37,40	lethal giant larvae	Lgl	16862(Tax:10090)	16862(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Distribution of lethal_giant_larvae -LRB- Lgl -RRB- protein in the tegument and negative impact of siRNA-based gene silencing on worm surface structure and egg hatching in Schistosoma_japonicum .
15901829	0	lethal_giant_larvae	50,69	Sanpodo	39,46	lethal giant larvae	Sanpodo	33156(Tax:7227)	318559(Tax:7227)	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Regulation of membrane localization of Sanpodo by lethal_giant_larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs .
20403420	0	leucine-rich-repeat-kinase_2	14,42	LRRK2	44,49	leucine-rich-repeat-kinase 2	LRRK2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of leucine-rich-repeat-kinase_2 -LRB- LRRK2 -RRB- during embryonic development .
16699948	0	leucine-rich_alpha-2-glycoprotein-1	6,41	cytochrome_c	48,60	leucine-rich alpha-2-glycoprotein-1	cytochrome c	116844	54205	Gene	Gene	binds|amod|START_ENTITY END_ENTITY|nsubj|binds	Serum leucine-rich_alpha-2-glycoprotein-1 binds cytochrome_c and inhibits antibody detection of this apoptotic marker in enzyme-linked immunosorbent assay .
22326293	0	leucine-rich_pentatricopeptide_repeat_motif-containing_protein	8,70	LRPPRC	72,78	leucine-rich pentatricopeptide repeat motif-containing protein	LRPPRC	10128	10128	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of leucine-rich_pentatricopeptide_repeat_motif-containing_protein -LRB- LRPPRC -RRB- for anti-apoptosis and tumourigenesis in cancers .
16725278	0	leucine-rich_repeat-containing_G-protein-coupled_receptor-7	28,87	RXFP1	89,94	leucine-rich repeat-containing G-protein-coupled receptor-7	RXFP1	295144(Tax:10116)	295144(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Comparative localization of leucine-rich_repeat-containing_G-protein-coupled_receptor-7 -LRB- RXFP1 -RRB- mRNA and -LSB- 33P -RSB- - relaxin binding sites in rat brain : restricted somatic co-expression a clue to relaxin action ?
24455684	0	leucine-rich_repeat-containing_g_protein-coupled_receptor_4	18,77	Stat3	0,5	leucine-rich repeat-containing g protein-coupled receptor 4	Stat3	55366	6774	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Stat3 upregulates leucine-rich_repeat-containing_g_protein-coupled_receptor_4 expression in osteosarcoma cells .
21088684	0	leucine-rich_repeat_kinase_2	12,40	LRRK2	42,47	leucine-rich repeat kinase 2	LRRK2	120892	120892	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- in Parkinson 's _ disease .
21806997	0	leucine-rich_repeat_kinase_2	27,55	LRRK2	57,62	leucine-rich repeat kinase 2	LRRK2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Autophosphorylation in the leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- GTPase domain modifies kinase and GTP-binding activities .
21972245	0	leucine-rich_repeat_kinase_2	61,89	LRRK2	91,96	leucine-rich repeat kinase 2	LRRK2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional responses to loss or gain of function of the leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- gene uncover biological processes modulated by LRRK2 activity .
22703868	0	leucine-rich_repeat_kinase_2	64,92	LRRK2	94,99	leucine-rich repeat kinase 2	LRRK2	120892	120892	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Dyskinesias in patients with Parkinson 's _ disease : effect of the leucine-rich_repeat_kinase_2 -LRB- LRRK2 -RRB- G2019S mutation .
17611037	0	leucine-rich_repeat_kinase_2	26,54	Lrrk2	56,61	leucine-rich repeat kinase 2	Lrrk2	66725(Tax:10090)	66725(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A comparative analysis of leucine-rich_repeat_kinase_2 -LRB- Lrrk2 -RRB- expression in mouse brain and Lewy_body_disease .
21420308	0	leucine_aminopeptidase	13,35	LAP	37,40	leucine aminopeptidase	LAP	7939	7939	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of leucine_aminopeptidase -LRB- LAP -RRB- like activity with wounding and methyl_jasmonate in pigeonpea -LRB- Cajanas cajan -RRB- suggests the role of these enzymes in plant defense in leguminosae .
3798485	0	leucine_aminopeptidase	14,36	LAP	38,41	leucine aminopeptidase	LAP	289668(Tax:10116)	289668(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of leucine_aminopeptidase -LRB- LAP -RRB- activity in the small intestines of rats exposed to dietary cadmium .
6813027	0	leucine_aminopeptidase	37,59	LAP	131,134	leucine aminopeptidase	LAP	7939	7939	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification and quantification of leucine_aminopeptidase in aged normal and cataractous human lenses and ability of bovine lens LAP to cleave bovine crystallins .
1551894	0	leucine_aminopeptidase	13,35	interferon-gamma	39,55	leucine aminopeptidase	interferon-gamma	7939	3458	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of leucine_aminopeptidase by interferon-gamma .
24446090	0	leucine_twenty_homeobox	4,27	LEUTX	29,34	leucine twenty homeobox	LEUTX	342900	342900	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The leucine_twenty_homeobox -LRB- LEUTX -RRB- gene , which lacks a histone acetyltransferase domain , is fused to KAT6A in therapy-related acute_myeloid_leukemia with t -LRB- 8 ; 19 -RRB- -LRB- p11 ; q13 -RRB- .
12186766	0	leucine_zipper-bearing_kinase	51,80	LZK	82,85	leucine zipper-bearing kinase	LZK	9175	9175	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and fine-mapping of the human leucine_zipper-bearing_kinase -LRB- LZK -RRB- gene .
7692935	0	leucocyte_adhesion_molecule-1	89,118	Granulocyte_colony-stimulating_factor	0,37	leucocyte adhesion molecule-1	Granulocyte colony-stimulating factor	6402	1440	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor down-regulates the surface expression of the human leucocyte_adhesion_molecule-1 on human neutrophils in vitro and in vivo .
24906639	0	leucocyte_immunoglobulin-like_receptor_A3	14,55	LILRA3	57,63	leucocyte immunoglobulin-like receptor A3	LILRA3	11026	11026	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of the leucocyte_immunoglobulin-like_receptor_A3 -LRB- LILRA3 -RRB- on susceptibility and subphenotypes of systemic_lupus_erythematosus and Sj gren 's syndrome .
639351	0	leucocyte_migration_inhibitory_factor	14,51	LIF	53,56	leucocyte migration inhibitory factor	LIF	3976	3976	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of leucocyte_migration_inhibitory_factor -LRB- LIF -RRB- in infectious_mononucleosis .
7032773	0	leucocyte_migration_inhibitory_factor	13,50	LIF	52,55	leucocyte migration inhibitory factor	LIF	100713602	100713602	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of leucocyte_migration_inhibitory_factor -LRB- LIF -RRB- by stimulation with free hapten and water-insoluble epoxy resin .
22500735	0	leucyl-tRNA_synthetase	10,32	TORC1	72,77	leucyl-tRNA synthetase	TORC1	51520	23373	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Hijacking leucyl-tRNA_synthetase for amino_acid-dependent regulation of TORC1 .
15919814	0	leucyl_tRNA_synthetase	32,54	LARS2	56,61	leucyl tRNA synthetase	LARS2	51520	23395	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence that the mitochondrial leucyl_tRNA_synthetase -LRB- LARS2 -RRB- gene represents a novel type 2 diabetes susceptibility gene .
10704254	0	leukaemia_inhibitory_factor	19,46	LIF	48,51	leukaemia inhibitory factor	LIF	3976	3976	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Renal synthesis of leukaemia_inhibitory_factor -LRB- LIF -RRB- , under normal and inflammatory conditions .
11349461	0	leukaemia_inhibitory_factor	9,36	LIF	38,41	leukaemia inhibitory factor	LIF	3976	3976	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Elevated leukaemia_inhibitory_factor -LRB- LIF -RRB- expression in lesional psoriatic skin : correlation with interleukin _ -LRB- IL -RRB- -8 expression .
11756390	0	leukaemia_inhibitory_factor	17,44	LIF	46,49	leukaemia inhibitory factor	LIF	3976	3976	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Concentration of leukaemia_inhibitory_factor -LRB- LIF -RRB- in uterine flushing fluid is highly predictive of embryo implantation .
1425017	0	leukaemia_inhibitory_factor	32,59	LIF	61,64	leukaemia inhibitory factor	LIF	3976	3976	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Reconstitution of high affinity leukaemia_inhibitory_factor -LRB- LIF -RRB- receptors in haemopoietic cells transfected with the cloned human LIF_receptor .
1461995	0	leukaemia_inhibitory_factor	14,41	LIF	43,46	leukaemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of leukaemia_inhibitory_factor -LRB- LIF -RRB- on embryogenesis .
16024536	0	leukaemia_inhibitory_factor	48,75	LIF	77,80	leukaemia inhibitory factor	LIF	3976	3976	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Removal of hydrosalpinges increases endometrial leukaemia_inhibitory_factor -LRB- LIF -RRB- expression at the time of the implantation window .
8568779	0	leukaemia_inhibitory_factor	27,54	LIF	56,59	leukaemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Trophic effects of myeloid leukaemia_inhibitory_factor -LRB- LIF -RRB- on mouse embryos .
8572536	0	leukaemia_inhibitory_factor	8,35	LIF	37,40	leukaemia inhibitory factor	LIF	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of leukaemia_inhibitory_factor -LRB- LIF -RRB- in rat peripheral nerve regeneration .
9124702	0	leukaemia_inhibitory_factor	39,66	LIF	68,71	leukaemia inhibitory factor	LIF	280840(Tax:9913)	280840(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic characterization of the bovine leukaemia_inhibitory_factor -LRB- LIF -RRB- gene : isolation and sequencing , chromosome assignment and microsatellite analysis .
9401818	0	leukaemia_inhibitory_factor	22,49	LIF	51,54	leukaemia inhibitory factor	LIF	3976	3976	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Controlled release of leukaemia_inhibitory_factor -LRB- LIF -RRB- to tissues .
17408753	0	leukaemia_inhibitory_factor	32,59	SOCS3	12,17	leukaemia inhibitory factor	SOCS3	16878(Tax:10090)	12702(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of SOCS3 in modulating leukaemia_inhibitory_factor signalling during murine placental development .
9617576	0	leukaemia_inhibitory_factor	7,34	interleukin_6	36,49	leukaemia inhibitory factor	interleukin 6	3976	3569	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Plasma leukaemia_inhibitory_factor , interleukin_6 and soluble interleukin_6 receptor levels during cardiopulmonary bypass with extracorporeal circulation .
26483157	0	leukemia-associated_RhoGEF	37,63	Cdk1	74,78	leukemia-associated RhoGEF	Cdk1	23365	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Mitotic-dependent phosphorylation of leukemia-associated_RhoGEF -LRB- LARG -RRB- by Cdk1 .
26483157	0	leukemia-associated_RhoGEF	37,63	LARG	65,69	leukemia-associated RhoGEF	LARG	23365	23365	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Mitotic-dependent phosphorylation of leukemia-associated_RhoGEF -LRB- LARG -RRB- by Cdk1 .
1477476	0	leukemia_inhibition_factor	11,37	Lif	44,47	leukemia inhibition factor	Lif	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The murine leukemia_inhibition_factor gene -LRB- Lif -RRB- is located on proximal chromosome 11 , not chromosome 13 .
19325217	0	leukemia_inhibitory_factor	31,57	Agrin	0,5	leukemia inhibitory factor	Agrin	16878(Tax:10090)	11603(Tax:10090)	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	Agrin pathway is controlled by leukemia_inhibitory_factor -LRB- LIF -RRB- in murine implantation .
14657014	0	leukemia_inhibitory_factor	91,117	Cochlin	0,7	leukemia inhibitory factor	Cochlin	16878(Tax:10090)	12810(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cochlin , a secreted von_Willebrand factor type a domain-containing factor , is regulated by leukemia_inhibitory_factor in the uterus at the time of embryo implantation .
12417666	0	leukemia_inhibitory_factor	77,103	Damage-induced_neuronal_endopeptidase	0,37	leukemia inhibitory factor	Damage-induced neuronal endopeptidase	60584(Tax:10116)	60417(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Damage-induced_neuronal_endopeptidase -LRB- DINE/ECEL -RRB- expression is regulated by leukemia_inhibitory_factor and deprivation of nerve_growth_factor in rat sensory ganglia after nerve_injury .
8432990	0	leukemia_inhibitory_factor	13,39	IL-1_and_tumor_necrosis_factor-alpha	73,109	leukemia inhibitory factor	IL-1 and tumor necrosis factor-alpha	3976	3552;7124	Gene	Gene	Induction|nmod|START_ENTITY fibroblasts|nsubj|Induction fibroblasts|nmod|END_ENTITY	Induction of leukemia_inhibitory_factor in human synovial fibroblasts by IL-1_and_tumor_necrosis_factor-alpha .
7805751	0	leukemia_inhibitory_factor	64,90	Interleukin-4	0,13	leukemia inhibitory factor	Interleukin-4	3976	3565	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-4 but not interleukin-10 inhibits the production of leukemia_inhibitory_factor by rheumatoid synovium and synoviocytes .
11587067	0	leukemia_inhibitory_factor	108,134	LIF	136,139	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Linkage disequilibrium and haplotype analysis among four novel single-nucleotide polymorphisms in the human leukemia_inhibitory_factor -LRB- LIF -RRB- gene .
14673505	0	leukemia_inhibitory_factor	66,92	LIF	98,101	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Cloning , eukaryotic expression and function assay of recombinant leukemia_inhibitory_factor gene LIF -RSB- .
14970834	0	leukemia_inhibitory_factor	83,109	LIF	111,114	leukemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia_inhibitory_factor -LRB- LIF -RRB- gene .
1561703	0	leukemia_inhibitory_factor	27,53	LIF	55,58	leukemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive expression of leukemia_inhibitory_factor -LRB- LIF -RRB- mRNA and production of LIF by a cloned murine thymic stromal cell line .
15685635	0	leukemia_inhibitory_factor	10,36	LIF	38,41	leukemia inhibitory factor	LIF	280840(Tax:9913)	280840(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of leukemia_inhibitory_factor -LRB- LIF -RRB- on in vitro produced bovine embryos and their outgrowth colonies .
15889014	0	leukemia_inhibitory_factor	25,51	LIF	53,56	leukemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Transgenic expression of leukemia_inhibitory_factor -LRB- LIF -RRB- blocks normal vascular development but not pathological neovascularization in the eye .
18672620	0	leukemia_inhibitory_factor	10,36	LIF	38,41	leukemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of leukemia_inhibitory_factor -LRB- LIF -RRB- on the quality of in vitro produced mouse blastocysts and subsequent derivation of embryonic stem -LRB- ES -RRB- cells .
1950765	0	leukemia_inhibitory_factor	11,37	LIF	39,42	leukemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of leukemia_inhibitory_factor -LRB- LIF -RRB- on gene transfer efficiency into murine hematolymphoid progenitors .
21191816	0	leukemia_inhibitory_factor	28,54	LIF	56,59	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Epigenetic up-regulation of leukemia_inhibitory_factor -LRB- LIF -RRB- gene during the progression to breast_cancer .
21613225	0	leukemia_inhibitory_factor	37,63	LIF	65,68	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Extensive mannose phosphorylation on leukemia_inhibitory_factor -LRB- LIF -RRB- controls its extracellular levels by multiple mechanisms .
21729793	0	leukemia_inhibitory_factor	14,40	LIF	42,45	leukemia inhibitory factor	LIF	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of leukemia_inhibitory_factor -LRB- LIF -RRB- in a rat model of postoperative_pain .
23628981	0	leukemia_inhibitory_factor	93,119	LIF	121,124	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High-level expression and efficient one-step chromatographic purification of a soluble human leukemia_inhibitory_factor -LRB- LIF -RRB- in Escherichia_coli .
23831429	0	leukemia_inhibitory_factor	15,41	LIF	10,13	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Impact of LIF -LRB- leukemia_inhibitory_factor -RRB- expression in malignant_melanoma .
2491897	0	leukemia_inhibitory_factor	19,45	LIF	47,50	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for human leukemia_inhibitory_factor -LRB- LIF -RRB- maps to 22q12 .
25162623	0	leukemia_inhibitory_factor	16,42	LIF	44,47	leukemia inhibitory factor	LIF	555717(Tax:7955)	555717(Tax:7955)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of leukemia_inhibitory_factor -LRB- LIF -RRB- during the early stage of optic nerve regeneration in zebrafish .
7999791	0	leukemia_inhibitory_factor	31,57	LIF	59,62	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High level expression of human leukemia_inhibitory_factor -LRB- LIF -RRB- from a synthetic gene in Escherichia_coli and the physical and biological characterization of the protein .
8260605	0	leukemia_inhibitory_factor	95,121	LIF	123,126	leukemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Delineation of positive and negative control elements within the promoter region of the murine leukemia_inhibitory_factor -LRB- LIF -RRB- gene .
8770940	0	leukemia_inhibitory_factor	17,43	LIF	45,48	leukemia inhibitory factor	LIF	16878(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Disrupted murine leukemia_inhibitory_factor -LRB- LIF -RRB- gene attenuates adrenocorticotropic_hormone -LRB- ACTH -RRB- secretion .
8899749	0	leukemia_inhibitory_factor	23,49	LIF	51,54	leukemia inhibitory factor	LIF	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Neuronal expression of leukemia_inhibitory_factor -LRB- LIF -RRB- in the rat brain .
9052938	0	leukemia_inhibitory_factor	36,62	LIF	64,67	leukemia inhibitory factor	LIF	100358914(Tax:9986)	100358914(Tax:9986)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential hormonal regulation of leukemia_inhibitory_factor -LRB- LIF -RRB- in rabbit and mouse uterus .
9151079	0	leukemia_inhibitory_factor	13,39	LIF	41,44	leukemia inhibitory factor	LIF	3976	3976	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of leukemia_inhibitory_factor -LRB- LIF -RRB- on the survival , proliferation and differentiation of human erythroid progenitor cells .
9666105	0	leukemia_inhibitory_factor	10,36	LIF	38,41	leukemia inhibitory factor	LIF	60584(Tax:10116)	60584(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of leukemia_inhibitory_factor -LRB- LIF -RRB- on the morphology and survival of cultured hippocampal neurons and glial cells .
12153570	0	leukemia_inhibitory_factor	45,71	N-myc	0,5	leukemia inhibitory factor	N-myc	3976	4613	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	N-myc oncogene overexpression down-regulates leukemia_inhibitory_factor in neuroblastoma .
8145046	0	leukemia_inhibitory_factor	14,40	Oncostatin_M	0,12	leukemia inhibitory factor	Oncostatin M	3976	5008	Gene	Gene	induce|nsubj|START_ENTITY induce|advmod|END_ENTITY	Oncostatin_M , leukemia_inhibitory_factor , and interleukin_6 induce the proliferation of human plasmacytoma cells via the common signal transducer , gp130 .
10196143	0	leukemia_inhibitory_factor	72,98	STAT3	18,23	leukemia inhibitory factor	STAT3	16878(Tax:10090)	20848(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	Critical role for STAT3 in murine pituitary adrenocorticotropin hormone leukemia_inhibitory_factor signaling .
17608645	0	leukemia_inhibitory_factor	34,60	STAT3	25,30	leukemia inhibitory factor	STAT3	3976	6774	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Retrograde activation of STAT3 by leukemia_inhibitory_factor in sympathetic neurons .
18088375	0	leukemia_inhibitory_factor	38,64	STAT3	0,5	leukemia inhibitory factor	STAT3	16878(Tax:10090)	20848(Tax:10090)	Gene	Gene	photoreceptors|nmod|START_ENTITY activation|nmod|photoreceptors activation|nummod|END_ENTITY	STAT3 activation in photoreceptors by leukemia_inhibitory_factor is associated with protection from light damage .
21305673	0	leukemia_inhibitory_factor	100,126	STAT3	127,132	leukemia inhibitory factor	STAT3	16878(Tax:10090)	20848(Tax:10090)	Gene	Gene	signaling|dep|START_ENTITY signaling|compound|END_ENTITY	LacdiNAc -LRB- GalNAcb1-4GlcNAc -RRB- contributes to self-renewal of mouse embryonic stem cells by regulating leukemia_inhibitory_factor / STAT3 signaling .
17925034	0	leukemia_inhibitory_factor	59,85	Stat3	29,34	leukemia inhibitory factor	Stat3	3976	6774	Gene	Gene	dependent|nmod|START_ENTITY signaling|dep|dependent signaling|nsubj|activation activation|amod|END_ENTITY	Mouse mammary_tumors display Stat3 activation dependent on leukemia_inhibitory_factor signaling .
20959490	0	leukemia_inhibitory_factor	158,184	Stat3	121,126	leukemia inhibitory factor	Stat3	16878(Tax:10090)	20848(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY signaling|dep|induced END_ENTITY|acl|signaling	Gprc5a deletion enhances the transformed phenotype in normal and malignant lung epithelial cells by eliciting persistent Stat3 signaling induced by autocrine leukemia_inhibitory_factor .
8313662	0	leukemia_inhibitory_factor	53,79	Tumor_necrosis_factor_alpha	0,27	leukemia inhibitory factor	Tumor necrosis factor alpha	3976	7124	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha stimulates production of leukemia_inhibitory_factor in human dermal fibroblast cultures .
9446634	0	leukemia_inhibitory_factor	71,97	WT1	48,51	leukemia inhibitory factor	WT1	16878(Tax:10090)	22431(Tax:10090)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|Expression Expression|appos|END_ENTITY	Expression of the Wilms ' _ tumor suppressor gene , WT1 , is upregulated by leukemia_inhibitory_factor and induces monocytic differentiation in M1 leukemic cells .
19646521	0	leukemia_inhibitory_factor	46,72	bone_morphogenetic_protein_2	93,121	leukemia inhibitory factor	bone morphogenetic protein 2	16878(Tax:10090)	12156(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Retinal astrocyte differentiation mediated by leukemia_inhibitory_factor in cooperation with bone_morphogenetic_protein_2 .
10207005	1	leukemia_inhibitory_factor	95,121	ciliary_neurotrophic_factor	149,176	leukemia inhibitory factor	ciliary neurotrophic factor	3976	1270	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Transfer of the leukemia_inhibitory_factor receptor-binding site from ciliary_neurotrophic_factor to interleukin-6 .
11358450	0	leukemia_inhibitory_factor	11,37	galanin	41,48	leukemia inhibitory factor	galanin	16878(Tax:10090)	14419(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of leukemia_inhibitory_factor on galanin expression and on axonal growth in adult dorsal root ganglion neurons in vitro .
21079661	0	leukemia_inhibitory_factor	11,37	gp130	41,46	leukemia inhibitory factor	gp130	16878(Tax:10090)	16195(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effects of leukemia_inhibitory_factor on gp130 expression and rate of metaphase II development during in vitro maturation of mouse oocyte .
1421375	0	leukemia_inhibitory_factor	80,106	interleukin-6	58,71	leukemia inhibitory factor	interleukin-6	3976	3569	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Involvement of nuclear factor-kappa B in induction of the interleukin-6 gene by leukemia_inhibitory_factor .
1429553	0	leukemia_inhibitory_factor	85,111	interleukin_6_receptors	19,42	leukemia inhibitory factor	interleukin 6 receptors	16878(Tax:10090)	16194(Tax:10090)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of interleukin_6_receptors of mouse myelomonocytic_leukemic cells by leukemia_inhibitory_factor .
21559730	0	leukemia_inhibitory_factor	15,41	lif	43,46	leukemia inhibitory factor	lif	3976	3976	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of leukemia_inhibitory_factor -LRB- lif -RRB- on cell multiplication and locomotion in human teratocarcinoma cells .
19913910	0	leukemia_inhibitory_factor	66,92	p38_mitogen-activated_protein_kinase	12,48	leukemia inhibitory factor	p38 mitogen-activated protein kinase	3976	1432	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	The role of p38_mitogen-activated_protein_kinase in serum-induced leukemia_inhibitory_factor secretion by bone marrow stromal cells from pediatric myelodysplastic_syndromes .
9489716	0	leukemia_inhibitory_factor	59,85	peripherin	40,50	leukemia inhibitory factor	peripherin	16878(Tax:10090)	19132(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Transcriptional activation of the mouse peripherin gene by leukemia_inhibitory_factor : involvement of STAT proteins .
15372367	0	leukemia_inhibitory_factor-receptor	21,56	LIF-R	58,63	leukemia inhibitory factor-receptor	LIF-R	3977	3977	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Mutation analysis of leukemia_inhibitory_factor-receptor -LRB- LIF-R -RRB- in ACTH-secreting pituitary_adenomas .
11160222	0	leukocyte-associated_Ig-like_receptor-1	39,78	SHP-1	28,33	leukocyte-associated Ig-like receptor-1	SHP-1	3903	5777	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Constitutive association of SHP-1 with leukocyte-associated_Ig-like_receptor-1 in human T cells .
23778340	0	leukocyte-associated_immunoglobulin-like_receptor-1	14,65	LAIR-1	67,73	leukocyte-associated immunoglobulin-like receptor-1	LAIR-1	3903	3903	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of leukocyte-associated_immunoglobulin-like_receptor-1 -LRB- LAIR-1 -RRB- on osteoclasts and its potential role in rheumatoid_arthritis .
1709244	0	leukocyte_adhesion_molecule-1	14,43	TQ1	45,48	leukocyte adhesion molecule-1	TQ1	6402	6402	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of leukocyte_adhesion_molecule-1 -LRB- TQ1 , Leu-8 -RRB- expression and shedding by normal and malignant cells .
1486801	0	leukocyte_antigen-related_tyrosine_phosphatase	13,59	LAR	61,64	leukocyte antigen-related tyrosine phosphatase	LAR	5792	5792	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for leukocyte_antigen-related_tyrosine_phosphatase -LRB- LAR -RRB- is localized to human chromosome 1p32 , a region frequently deleted in tumors of neuroectodermal origin .
23283466	0	leukocyte_antigen_class_II	30,56	DRB1	58,62	leukocyte antigen class II	DRB1	3127	3123	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Association analysis of human leukocyte_antigen_class_II -LRB- DRB1 -RRB- alleles with leprosy in individuals from S o Lu s , state of Maranh o , Brazil .
24076354	0	leukocyte_cell-derived_chemotaxin-2	46,81	LECT2	83,88	leukocyte cell-derived chemotaxin-2	LECT2	101797061	101797061	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and expression analysis of the leukocyte_cell-derived_chemotaxin-2 -LRB- LECT2 -RRB- gene in duck -LRB- Anas_platyrhynchos -RRB- .
24390366	0	leukocyte_cell-derived_chemotaxin_2	16,51	LECT2	53,58	leukocyte cell-derived chemotaxin 2	LECT2	3950	3950	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increased serum leukocyte_cell-derived_chemotaxin_2 -LRB- LECT2 -RRB- levels in obesity_and_fatty_liver .
15239100	0	leukocyte_cell-derived_chemotaxin_2	22,57	beta-catenin	85,97	leukocyte cell-derived chemotaxin 2	beta-catenin	3950	1499	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Identification of the leukocyte_cell-derived_chemotaxin_2 as a direct target gene of beta-catenin in the liver .
1961179	0	leukocyte_elastase	19,37	PMNE	39,43	leukocyte elastase	PMNE	1991	1991	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	-LSB- Polymorphonuclear leukocyte_elastase -LRB- PMNE -RRB- levels in surgical patients with postoperative_infections -RSB- .
2788801	0	leukocyte_elastase	19,37	PMNE	39,43	leukocyte elastase	PMNE	1991	1991	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Polymorphonuclear leukocyte_elastase -LRB- PMNE -RRB- levels in sepsis ; the effect of PMNE on multiple_organ_failure -LRB- MOF -RRB- -RSB- .
9608630	0	leukocyte_elastase	74,92	PMNE	94,98	leukocyte elastase	PMNE	1991	1991	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Convulsions in hemodialysis -LRB- HD -RRB- patients with elevated polymorphonuclear leukocyte_elastase -LRB- PMNE -RRB- levels .
1669448	0	leukocyte_elastase	90,108	pancreatic_secretory_trypsin_inhibitor	34,72	leukocyte elastase	pancreatic secretory trypsin inhibitor	1991	574092(Tax:9913)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the bovine and porcine pancreatic_secretory_trypsin_inhibitor -LRB- Kazal -RRB- to human leukocyte_elastase : a thermodynamic study .
3301869	0	leukocyte_function-associated_antigen-1	15,54	LFA-1	56,61	leukocyte function-associated antigen-1	LFA-1	3683	3683	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of leukocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- in the invasion of hepatocyte cultures by lymphoma and T-cell hybridoma cells .
12324444	0	leukocyte_function-associated_antigen-1	26,65	intercellular_adhesion_molecule-1	66,99	leukocyte function-associated antigen-1	intercellular adhesion molecule-1	3683	3383	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Force spectroscopy of the leukocyte_function-associated_antigen-1 / intercellular_adhesion_molecule-1 interaction .
11312920	0	leukocyte_function-associated_antigen-1	46,85	intracellular_adhesion_molecule-1	86,119	leukocyte function-associated antigen-1	intracellular adhesion molecule-1	308995(Tax:10116)	25464(Tax:10116)	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Novel p-arylthio_cinnamides as antagonists of leukocyte_function-associated_antigen-1 / intracellular_adhesion_molecule-1 interaction .
618069	0	leukocyte_inhibiting_factor	28,55	LIF	57,60	leukocyte inhibiting factor	LIF	3976	3976	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	The effect of levamisole on leukocyte_inhibiting_factor -LRB- LIF -RRB- production `` in vitro '' .
3027180	0	leukocyte_inhibitory_factor	11,38	LIF	40,43	leukocyte inhibitory factor	LIF	3976	3976	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of leukocyte_inhibitory_factor -LRB- LIF -RRB- on neutrophil mediated antibody-dependent_cellular_cytotoxicity .
6305834	0	leukocyte_inhibitory_factor	11,38	LIF	40,43	leukocyte inhibitory factor	LIF	3976	3976	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of leukocyte_inhibitory_factor -LRB- LIF -RRB- on human neutrophil function .
852151	0	leukocyte_inhibitory_factor	14,41	LIF	43,46	leukocyte inhibitory factor	LIF	3976	3976	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of leukocyte_inhibitory_factor -LRB- LIF -RRB- in Hodgkin 's _ disease .
1106109	0	leukocyte_migration_inhibitory_factor	20,57	LIF	59,62	leukocyte migration inhibitory factor	LIF	3976	3976	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of human leukocyte_migration_inhibitory_factor -LRB- LIF -RRB- by alpha-L-fucose .
22367194	0	leukolysin	59,69	MMP25	115,120	leukolysin	MMP25	64386	64386	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biochemical characterization and N-terminomics analysis of leukolysin , the membrane-type 6 matrix metalloprotease -LRB- MMP25 -RRB- : chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities .
7768930	0	leukosialin	52,63	CD43	65,69	leukosialin	CD43	105369261	6693	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Tissue-specific transcriptional regulation of human leukosialin -LRB- CD43 -RRB- gene is achieved by DNA methylation .
8055899	0	leukosialin	36,47	CD43	49,53	leukosialin	CD43	105369261	6693	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Transcriptional activation of human leukosialin -LRB- CD43 -RRB- gene by Sp1 through binding to a GGGTGG motif .
2521952	0	leukosialin	41,52	leukosialin	77,88	leukosialin	leukosialin	105369261	105369261	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16 .
2521952	0	leukosialin	77,88	leukosialin	41,52	leukosialin	leukosialin	105369261	105369261	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16 .
8555027	0	leukotriene_A4_hydrolase	61,85	aminopeptidase	24,38	leukotriene A4 hydrolase	aminopeptidase	4048	10404	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Characterization of the aminopeptidase activity of epidermal leukotriene_A4_hydrolase against the opioid dynorphin fragment 1-7 .
6258182	0	leukotriene_B4	14,28	LTB4	30,34	leukotriene B4	LTB4	100135572(Tax:10141)	100135572(Tax:10141)	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	The action of leukotriene_B4 -LRB- LTB4 -RRB- on the lung .
10492403	0	leukotriene_B4_omega-hydroxylase	48,80	CYP4F2	82,88	leukotriene B4 omega-hydroxylase	CYP4F2	4051	8529	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression and molecular cloning of human liver leukotriene_B4_omega-hydroxylase -LRB- CYP4F2 -RRB- gene .
9539102	0	leukotriene_B4_omega-hydroxylase	6,38	CYP4F3	40,46	leukotriene B4 omega-hydroxylase	CYP4F3	4051	4051	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human leukotriene_B4_omega-hydroxylase -LRB- CYP4F3 -RRB- gene : molecular cloning and chromosomal localization .
20004699	0	leukotriene_B4_receptor_1	71,96	Th1	11,14	leukotriene B4 receptor 1	Th1	16995(Tax:10090)	57314(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|END_ENTITY	Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene_B4_receptor_1 .
9916739	0	leukotriene_C4_synthase	19,42	TGF-beta	0,8	leukotriene C4 synthase	TGF-beta	4056	7040	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	TGF-beta increases leukotriene_C4_synthase expression in the monocyte-like cell line , THP-1 .
8425605	0	leukotriene_C4_synthase	33,56	THP-1	60,65	leukotriene C4 synthase	THP-1	4056	2736	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Photoaffinity labelling of human leukotriene_C4_synthase in THP-1 cell membranes .
17329398	0	leupaxin	38,46	Pyk2	15,19	leupaxin	Pyk2	9404	2185	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Pyk2 and PTP-PEST with leupaxin in prostate_cancer cells .
16914530	0	leupaxin	15,23	Src	29,32	leupaxin	Src	107321(Tax:10090)	20779(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of leupaxin with Src in osteoclasts .
26361959	0	leupaxin	50,58	b-catenin	14,23	leupaxin	b-catenin	9404	1499	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of b-catenin transcription activity by leupaxin in hepatocellular_carcinoma .
2266131	0	leuserpin-2	27,38	thrombin	39,47	leuserpin-2	thrombin	3053	2147	Gene	Gene	START_ENTITY|dep|interaction interaction|compound|END_ENTITY	Glycosaminoglycan-mediated leuserpin-2 / thrombin interaction .
23142137	0	lgr5	69,73	Troy	0,4	lgr5	Troy	14160(Tax:10090)	29820(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Troy , a tumor necrosis factor receptor family member , interacts with lgr5 to inhibit wnt signaling in intestinal stem cells .
21559730	0	lif	43,46	leukemia_inhibitory_factor	15,41	lif	leukemia inhibitory factor	3976	3976	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	The effects of leukemia_inhibitory_factor -LRB- lif -RRB- on cell multiplication and locomotion in human teratocarcinoma cells .
19528180	0	lig	53,56	leptospiral_immunoglobulin-like	20,51	lig	leptospiral immunoglobulin-like	3093	3093	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Distribution of the leptospiral_immunoglobulin-like -LRB- lig -RRB- genes in pathogenic Leptospira species and application of ligB to typing leptospiral isolates .
411659	0	ligandin	19,27	glutathione-S-transferase	33,58	ligandin	glutathione-S-transferase	24422(Tax:10116)	373156	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	The preparation of ligandin with glutathione-S-transferase activity from porcine liver cytosol affinity chromatography on bromosulphophthalein-Sepharose .
23038268	0	light_chain_1	7,20	LC8	22,25	light chain 1	LC8	8655	8655	Gene	Gene	association|amod|START_ENTITY association|compound|END_ENTITY	Dynein light_chain_1 -LRB- LC8 -RRB- association enhances microtubule stability and promotes microtubule bundling .
15844168	0	limbic_system-associated_membrane_protein	20,61	LAMP	63,67	limbic system-associated membrane protein	LAMP	29561(Tax:10116)	29561(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of the limbic_system-associated_membrane_protein -LRB- LAMP -RRB- in pigeon forebrain and midbrain .
15081109	0	limbic_system-associated_membrane_protein	55,96	Lsamp	98,103	limbic system-associated membrane protein	Lsamp	268890(Tax:10090)	268890(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the genomic structure of the mouse limbic_system-associated_membrane_protein -LRB- Lsamp -RRB- gene .
17215302	0	lin-12	76,82	Notch	83,88	lin-12	Notch	176282(Tax:6239)	176282(Tax:6239)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	SEL-2 , the C. _ elegans neurobeachin/LRBA homolog , is a negative regulator of lin-12 / Notch activity and affects endosomal traffic in polarized epithelial cells .
8722778	0	lin-12	63,69	sel-1	27,32	lin-12	sel-1	176282(Tax:6239)	179720(Tax:6239)	Gene	Gene	regulator|acl|START_ENTITY gene|appos|regulator gene|amod|END_ENTITY	The Caenorhabditis_elegans sel-1 gene , a negative regulator of lin-12 and glp-1 , encodes a predicted extracellular protein .
1916265	0	lin-14	23,29	lin-4	91,96	lin-14	lin-4	181337(Tax:6239)	266860(Tax:6239)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes , lin-4 and lin-28 .
24058689	0	lin-14	23,29	lin-4	49,54	lin-14	lin-4	181337(Tax:6239)	266860(Tax:6239)	Gene	Gene	mRNA|amod|START_ENTITY regulation|nmod|mRNA regulation|nmod|miRNA miRNA|amod|END_ENTITY	Dual regulation of the lin-14 target mRNA by the lin-4 miRNA .
8252621	0	lin-14	93,99	lin-4	34,39	lin-14	lin-4	181337(Tax:6239)	266860(Tax:6239)	Gene	Gene	elegans|nmod|START_ENTITY elegans|dobj|RNAs RNAs|amod|END_ENTITY	The C. _ elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 .
8957004	0	lin-14	15,21	lin-4	9,14	lin-14	lin-4	181337(Tax:6239)	266860(Tax:6239)	Gene	Gene	duplex|amod|START_ENTITY sufficient|nsubj|duplex END_ENTITY|parataxis|sufficient	A bulged lin-4 / lin-14 RNA duplex is sufficient for Caenorhabditis_elegans lin-14 temporal gradient formation .
8957004	0	lin-14	74,80	lin-4	9,14	lin-14	lin-4	181337(Tax:6239)	266860(Tax:6239)	Gene	Gene	formation|amod|START_ENTITY sufficient|nmod|formation END_ENTITY|parataxis|sufficient	A bulged lin-4 / lin-14 RNA duplex is sufficient for Caenorhabditis_elegans lin-14 temporal gradient formation .
9806929	0	lin-25	23,29	sur-2	86,91	lin-25	sur-2	179732(Tax:6239)	173345(Tax:6239)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Caenorhabditis_elegans lin-25 : cellular focus , protein expression and requirement for sur-2 during induction of vulval fates .
24885717	0	lin-39	58,64	Hox	49,52	lin-39	Hox	176068(Tax:6239)	42536(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. _ elegans embryo and larva , including the hypodermal fate regulators LIN-26 and ELT-6 .
10642801	0	lin-4	4,9	LIN-14	93,99	lin-4	LIN-14	266860(Tax:6239)	181337(Tax:6239)	Gene	Gene	RNA|amod|START_ENTITY controls|nsubj|RNA controls|advcl|blocking blocking|dobj|synthesis synthesis|compound|END_ENTITY	The lin-4 regulatory RNA controls developmental timing in Caenorhabditis_elegans by blocking LIN-14 protein synthesis after the initiation of translation .
22692424	0	lin-4	4,9	LIN-14	31,37	lin-4	LIN-14	266860(Tax:6239)	181337(Tax:6239)	Gene	Gene	microRNA|amod|START_ENTITY targets|nsubj|microRNA targets|dobj|factor factor|compound|END_ENTITY	The lin-4 microRNA targets the LIN-14 transcription factor to inhibit netrin-mediated axon attraction .
1916265	0	lin-4	91,96	lin-14	23,29	lin-4	lin-14	266860(Tax:6239)	181337(Tax:6239)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes , lin-4 and lin-28 .
24058689	0	lin-4	49,54	lin-14	23,29	lin-4	lin-14	266860(Tax:6239)	181337(Tax:6239)	Gene	Gene	miRNA|amod|START_ENTITY regulation|nmod|miRNA regulation|nmod|mRNA mRNA|amod|END_ENTITY	Dual regulation of the lin-14 target mRNA by the lin-4 miRNA .
8252621	0	lin-4	34,39	lin-14	93,99	lin-4	lin-14	266860(Tax:6239)	181337(Tax:6239)	Gene	Gene	RNAs|amod|START_ENTITY elegans|dobj|RNAs elegans|nmod|END_ENTITY	The C. _ elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 .
8957004	0	lin-4	9,14	lin-14	15,21	lin-4	lin-14	266860(Tax:6239)	181337(Tax:6239)	Gene	Gene	START_ENTITY|parataxis|sufficient sufficient|nsubj|duplex duplex|amod|END_ENTITY	A bulged lin-4 / lin-14 RNA duplex is sufficient for Caenorhabditis_elegans lin-14 temporal gradient formation .
8957004	0	lin-4	9,14	lin-14	74,80	lin-4	lin-14	266860(Tax:6239)	181337(Tax:6239)	Gene	Gene	START_ENTITY|parataxis|sufficient sufficient|nmod|formation formation|amod|END_ENTITY	A bulged lin-4 / lin-14 RNA duplex is sufficient for Caenorhabditis_elegans lin-14 temporal gradient formation .
20163606	0	lingual_antimicrobial_peptide	22,51	LAP	53,56	lingual antimicrobial peptide	LAP	403090(Tax:9913)	403090(Tax:9913)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of lingual_antimicrobial_peptide -LRB- LAP -RRB- in the bovine mammary gland .
10640815	0	link_protein	54,66	Crtl1	73,78	link protein	Crtl1	12950(Tax:10090)	12950(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization and chromosome location of the mouse link_protein gene -LRB- Crtl1 -RRB- .
17010228	0	lipase	44,50	Leptin	0,6	lipase	Leptin	291437(Tax:10116)	25608(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Leptin directly regulates exocrine pancreas lipase and two related proteins in the rat .
12518034	0	lipase	38,44	lipase	98,104	lipase	lipase	16891(Tax:10090)	16891(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of human hormone-sensitive lipase in white adipose tissue of transgenic_mice increases lipase activity but does not enhance in vitro lipolysis .
12518034	0	lipase	98,104	lipase	38,44	lipase	lipase	16891(Tax:10090)	16891(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of human hormone-sensitive lipase in white adipose tissue of transgenic_mice increases lipase activity but does not enhance in vitro lipolysis .
17333281	0	lipase_H	18,26	LIPH	28,32	lipase H	LIPH	200879	200879	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A mutation in the lipase_H -LRB- LIPH -RRB- gene underlie autosomal recessive hypotrichosis .
19167195	0	lipase_H	28,36	LIPH	38,42	lipase H	LIPH	200879	200879	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel missense mutations in lipase_H -LRB- LIPH -RRB- gene causing autosomal_recessive_hypotrichosis -LRB- LAH2 -RRB- .
17118936	0	lipid_droplet-associated_protein	36,68	Prp19p	24,30	lipid droplet-associated protein	Prp19p	103968(Tax:10090)	28000(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of mouse Prp19p as a lipid_droplet-associated_protein and its possible involvement in the biogenesis of lipid droplets .
10409760	0	lipocalin	57,66	p20K	52,56	lipocalin	p20K	424893(Tax:9031)	396393(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	C/EBPbeta -LRB- NF-M -RRB- is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts .
24029383	0	lipocalin-prostaglandin_D_synthase	40,74	Nrf2	0,4	lipocalin-prostaglandin D synthase	Nrf2	19215(Tax:10090)	18024(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY essential|nmod|expression essential|nsubj|END_ENTITY	Nrf2 is essential for the expression of lipocalin-prostaglandin_D_synthase induced by prostaglandin_D2 .
24029383	0	lipocalin-prostaglandin_D_synthase	40,74	prostaglandin_D2	86,102	lipocalin-prostaglandin D synthase	prostaglandin D2	19215(Tax:10090)	19215(Tax:10090)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Nrf2 is essential for the expression of lipocalin-prostaglandin_D_synthase induced by prostaglandin_D2 .
21132267	0	lipocalin_2	82,93	JNK	114,117	lipocalin 2	JNK	3934	5599	Gene	Gene	START_ENTITY|nmod|blockade blockade|nmod|END_ENTITY	Inhibition of the proliferation and invasion of hepatocellular_carcinoma cells by lipocalin_2 through blockade of JNK and PI3K/Akt signaling .
23483583	0	lipocalin_2	35,46	TLR-4	20,25	lipocalin 2	TLR-4	16819(Tax:10090)	21898(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY mediated|dobj|expression mediated|nsubj|END_ENTITY	Nitric_oxide boosts TLR-4 mediated lipocalin_2 expression in chondrocytes .
22533572	0	lipocalin_2	8,19	matrix_metalloproteinase-9	41,67	lipocalin 2	matrix metalloproteinase-9	3934	4318	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of lipocalin_2 and its complex with matrix_metalloproteinase-9 in oral_cancer .
18398717	0	lipocalin_2	15,26	myeloid_leukemia	39,55	lipocalin 2	myeloid leukemia	16819(Tax:10090)	14025(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|nmod|END_ENTITY	Requirement of lipocalin_2 for chronic myeloid_leukemia .
8910300	0	lipocortin-1	73,85	hepatocyte_growth_factor	129,153	lipocortin-1	hepatocyte growth factor	301	3082	Gene	Gene	phosphorylation|nmod|START_ENTITY transduces|nsubj|phosphorylation transduces|dobj|signal signal|nmod|END_ENTITY	The hepatocyte_growth_factor receptor kinase-mediated phosphorylation of lipocortin-1 transduces the proliferating signal of the hepatocyte_growth_factor .
8910300	0	lipocortin-1	73,85	hepatocyte_growth_factor	4,28	lipocortin-1	hepatocyte growth factor	301	3082	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	The hepatocyte_growth_factor receptor kinase-mediated phosphorylation of lipocortin-1 transduces the proliferating signal of the hepatocyte_growth_factor .
9321960	0	lipocortin_1	30,42	IL-1_beta	63,72	lipocortin 1	IL-1 beta	301	3553	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The co-ordinate regulation of lipocortin_1 , COX_2 and cPLA2 by IL-1_beta in A549 cells .
11311405	0	lipocortin_1	44,56	Interleukin-1beta	0,17	lipocortin 1	Interleukin-1beta	25380(Tax:10116)	24494(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY expression|nmod|mRNA induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces the expression of lipocortin_1 mRNA in cultured rat cortical astrocytes .
1314068	0	lipocortin_II	35,48	annexin_II	23,33	lipocortin II	annexin II	302	302	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of annexin_II -LRB- lipocortin_II , p36 -RRB- in a multidrug resistant small_cell_lung_cancer cell line .
2144635	0	lipocortin_V	50,62	placental_anticoagulant_protein-I	15,48	lipocortin V	placental anticoagulant protein-I	308	308	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of placental_anticoagulant_protein-I -LRB- lipocortin_V -RRB- with model membranes .
25078593	0	lipoic_acid_synthase	26,46	LIAS	48,52	lipoic acid synthase	LIAS	100627627	100627627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the porcine lipoic_acid_synthase -LRB- LIAS -RRB- gene in Escherichia_coli .
12441356	0	lipoma-preferred_partner	72,96	LPP	98,101	lipoma-preferred partner	LPP	4026	4026	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred_partner -LRB- LPP -RRB- protein .
16752389	0	lipoma_HMGIC_fusion_partner-like_5	17,51	LHFPL5	53,59	lipoma HMGIC fusion partner-like 5	LHFPL5	222662	222662	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the lipoma_HMGIC_fusion_partner-like_5 -LRB- LHFPL5 -RRB- gene cause autosomal_recessive_nonsyndromic_hearing_loss .
24026232	0	lipopolysaccharide-binding-protein	76,110	C-reactive_protein	127,145	lipopolysaccharide-binding-protein	C-reactive protein	3929	1401	Gene	Gene	count|amod|START_ENTITY count|amod|END_ENTITY	Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein , interleukin_6 , C-reactive_protein , white blood cell count , erythrocyte sedimentation rate and body temperature .
24026232	0	lipopolysaccharide-binding-protein	76,110	interleukin_6	112,125	lipopolysaccharide-binding-protein	interleukin 6	3929	3569	Gene	Gene	count|amod|START_ENTITY count|amod|END_ENTITY	Infection surveillance in transsphenoidal pituitary surgery - comparison of lipopolysaccharide-binding-protein , interleukin_6 , C-reactive_protein , white blood cell count , erythrocyte sedimentation rate and body temperature .
12856185	0	lipopolysaccharide-binding_protein	18,52	LBP	54,57	lipopolysaccharide-binding protein	LBP	3929	3929	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Clinical value of lipopolysaccharide-binding_protein -LRB- LBP -RRB- determinations in acute pancreatitis .
22733492	0	lipopolysaccharide-binding_protein	13,47	LBP	49,52	lipopolysaccharide-binding protein	LBP	512242(Tax:9913)	512242(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in lipopolysaccharide-binding_protein -LRB- LBP -RRB- gene change the susceptibility to clinical mastitis in Chinese Holstein .
15082348	0	lipopolysaccharide-binding_protein	7,41	TNF-alpha	101,110	lipopolysaccharide-binding protein	TNF-alpha	29469(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Tissue lipopolysaccharide-binding_protein expression in rats after thermal injury : potential role of TNF-alpha .
9287245	0	lipopolysaccharide_binding_protein	45,79	LBP	81,84	lipopolysaccharide binding protein	LBP	3929	3929	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Control of transcriptional activation of the lipopolysaccharide_binding_protein -LRB- LBP -RRB- gene by proinflammatory cytokines .
21871094	0	lipopolysaccharide_or_IL-1	50,76	High_mobility_group_box_protein_1	0,33	lipopolysaccharide or IL-1	High mobility group box protein 1	3552	3146	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	High_mobility_group_box_protein_1 in complex with lipopolysaccharide_or_IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts .
1811340	0	lipoprotein-associated_coagulation_inhibitor	10,54	LACI	56,60	lipoprotein-associated coagulation inhibitor	LACI	7035	7035	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of lipoprotein-associated_coagulation_inhibitor -LRB- LACI -RRB- on thromboplastin-induced coagulation of normal and hemophiliac plasmas .
25836672	0	lipoprotein-associated_phospholipase_A2	30,69	Apolipoprotein_CIII	0,19	lipoprotein-associated phospholipase A2	Apolipoprotein CIII	7941	345	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Apolipoprotein_CIII regulates lipoprotein-associated_phospholipase_A2 expression via the MAPK and NFkB pathways .
21241231	0	lipoprotein-associated_phospholipase_A2	12,51	Lp-PLA	53,59	lipoprotein-associated phospholipase A2	Lp-PLA	7941	7941	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA -RRB- in cardiovascular_disease .
17928209	0	lipoprotein-associated_phospholipase_A2	61,100	Lp-PLA2	102,109	lipoprotein-associated phospholipase A2	Lp-PLA2	7941	7941	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of a low-calorie diet associated with weight_loss on lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity in healthy obese women .
23413990	0	lipoprotein-associated_phospholipase_A2	51,90	Lp-PLA2	92,99	lipoprotein-associated phospholipase A2	Lp-PLA2	7941	7941	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Influence of obesity and cardiometabolic makers on lipoprotein-associated_phospholipase_A2 -LRB- Lp-PLA2 -RRB- activity in adolescents : the healthy young cross-sectional study .
18560444	0	lipoprotein_a	99,112	Lpa	114,117	lipoprotein a	Lpa	4018	4018	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Genome-wide linkage analysis for identifying quantitative trait loci involved in the regulation of lipoprotein_a -LRB- Lpa -RRB- levels .
8408618	0	lipoprotein_apolipoproteins_A-I_and_A-II	35,75	cholesteryl_ester_transfer_protein	85,119	lipoprotein apolipoproteins A-I and A-II	cholesteryl ester transfer protein	114548	1071	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|compound|END_ENTITY	Delayed catabolism of high density lipoprotein_apolipoproteins_A-I_and_A-II in human cholesteryl_ester_transfer_protein deficiency .
15328075	0	lipoprotein_lipase	65,83	AMPK	23,27	lipoprotein lipase	AMPK	24539(Tax:10116)	78975(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The metabolic `` switch '' AMPK regulates cardiac heparin-releasable lipoprotein_lipase .
22772754	0	lipoprotein_lipase	50,68	ATP-binding_cassette_G1	6,29	lipoprotein lipase	ATP-binding cassette G1	4023	9619	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Human ATP-binding_cassette_G1 controls macrophage lipoprotein_lipase bioavailability and promotes foam cell formation .
27034464	0	lipoprotein_lipase	68,86	Angiopoietin-like_4	0,19	lipoprotein lipase	Angiopoietin-like 4	16956(Tax:10090)	57875(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Angiopoietin-like_4 -LRB- ANGPTL4 -RRB- promotes intracellular degradation of lipoprotein_lipase in adipocytes .
20581395	0	lipoprotein_lipase	37,55	Angiopoietin-like_protein_3	0,27	lipoprotein lipase	Angiopoietin-like protein 3	4023	27329	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Angiopoietin-like_protein_3 inhibits lipoprotein_lipase activity through enhancing its cleavage by proprotein convertases .
23960078	0	lipoprotein_lipase	42,60	Angiopoietin-like_protein_4	0,27	lipoprotein lipase	Angiopoietin-like protein 4	4023	51129	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Angiopoietin-like_protein_4 inhibition of lipoprotein_lipase : evidence for reversible complex formation .
24397894	0	lipoprotein_lipase	14,32	Angptl4	36,43	lipoprotein lipase	Angptl4	4023	51129	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of lipoprotein_lipase by Angptl4 .
2307668	0	lipoprotein_lipase	34,52	ApoC-II	12,19	lipoprotein lipase	ApoC-II	4023	344	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Lipoprotein ApoC-II activation of lipoprotein_lipase .
18708524	0	lipoprotein_lipase	39,57	C-reactive_protein	0,18	lipoprotein lipase	C-reactive protein	4023	1401	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	C-reactive_protein enhances macrophage lipoprotein_lipase expression .
12586369	0	lipoprotein_lipase	50,68	FKHR	32,36	lipoprotein lipase	FKHR	16956(Tax:10090)	56458(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	A forkhead transcription factor FKHR up-regulates lipoprotein_lipase expression in skeletal muscle .
7686151	0	lipoprotein_lipase	81,99	Glycoprotein_330	0,16	lipoprotein lipase	Glycoprotein 330	4023	4036	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Glycoprotein_330 , a member of the low_density_lipoprotein_receptor family , binds lipoprotein_lipase in vitro .
10407500	0	lipoprotein_lipase	30,48	LPL	50,53	lipoprotein lipase	LPL	4023	4023	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Evidence of a major locus for lipoprotein_lipase -LRB- LPL -RRB- activity in addition to a pleiotropic locus for both LPL and fasting insulin : results from the HERITAGE Family Study .
11395037	0	lipoprotein_lipase	24,42	LPL	49,52	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common mutations in the lipoprotein_lipase gene -LRB- LPL -RRB- : effects on HDL-cholesterol levels in a Chinese Canadian population .
12687649	0	lipoprotein_lipase	20,38	LPL	40,43	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between lipoprotein_lipase -LRB- LPL -RRB- gene and blood lipids : a common variant for a common trait ?
1406652	0	lipoprotein_lipase	30,48	LPL	50,53	lipoprotein lipase	LPL	4023	4023	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Characterization of the human lipoprotein_lipase -LRB- LPL -RRB- promoter : evidence of two cis-regulatory regions , LP-alpha and LP-beta , of importance for the differentiation-linked induction of the LPL gene during adipogenesis .
1562620	0	lipoprotein_lipase	54,72	LPL	74,77	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A newly identified null allelic mutation in the human lipoprotein_lipase -LRB- LPL -RRB- gene of a compound heterozygote with familial_LPL_deficiency .
16029634	0	lipoprotein_lipase	15,33	LPL	35,38	lipoprotein lipase	LPL	4023	4023	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	-LSB- The effect of lipoprotein_lipase -LRB- LPL -RRB- polymorphism on plasma LPL concentration and triglyceride -RSB- .
17727701	0	lipoprotein_lipase	41,59	LPL	61,64	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The D9N , N291S and S447X variants in the lipoprotein_lipase -LRB- LPL -RRB- gene are not associated with Type_III_hyperlipidemia .
17890220	0	lipoprotein_lipase	96,114	LPL	116,119	lipoprotein lipase	LPL	24539(Tax:10116)	24539(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Resistin is a key mediator of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- stimulation of lipoprotein_lipase -LRB- LPL -RRB- activity in adipocytes .
18619685	0	lipoprotein_lipase	28,46	LPL	48,51	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Apolipoprotein_E -LRB- APOE -RRB- and lipoprotein_lipase -LRB- LPL -RRB- gene variants and carotid atherosclerotic_lesions in the oldest old : a population-based autopsy study .
18985010	0	lipoprotein_lipase	15,33	LPL	35,38	lipoprotein lipase	LPL	4023	4023	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of lipoprotein_lipase -LRB- LPL -RRB- single nucleotide polymorphisms with type_2_diabetes_mellitus .
21159338	0	lipoprotein_lipase	21,39	LPL	41,44	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rare variants in the lipoprotein_lipase -LRB- LPL -RRB- gene are common in hypertriglyceridemia but rare in Type_III_hyperlipidemia .
23271120	0	lipoprotein_lipase	70,88	LPL	90,93	lipoprotein lipase	LPL	280843(Tax:9913)	280843(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of novel single nucleotide polymorphisms -LRB- SNPs -RRB- of the lipoprotein_lipase -LRB- LPL -RRB- gene associated with fatty_acid composition in Korean cattle .
24314358	0	lipoprotein_lipase	45,63	LPL	65,68	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Resequencing the untranslated regions of the lipoprotein_lipase -LRB- LPL -RRB- gene reveals that variants in microRNA target sequences are associated with triglyceride levels .
7753827	0	lipoprotein_lipase	34,52	LPL	54,57	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A mutation in the promoter of the lipoprotein_lipase -LRB- LPL -RRB- gene in a patient with familial_combined_hyperlipidemia and low LPL activity .
8314591	0	lipoprotein_lipase	55,73	LPL	75,78	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human clusterin -LRB- CLI -RRB- maps to 8p21 in proximity to the lipoprotein_lipase -LRB- LPL -RRB- gene .
8449037	0	lipoprotein_lipase	24,42	LPL	44,47	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human lipoprotein_lipase -LRB- LPL -RRB- gene to chromosome band 8p22 .
8728326	0	lipoprotein_lipase	44,62	LPL	64,67	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Homozygosity for two point mutations in the lipoprotein_lipase -LRB- LPL -RRB- gene in a patient with familial_LPL_deficiency : LPL -LRB- Asp9 -- > Asn , Tyr262 -- > His -RRB- .
8732780	0	lipoprotein_lipase	37,55	LPL	92,95	lipoprotein lipase	LPL	16956(Tax:10090)	16956(Tax:10090)	Gene	Gene	production|amod|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of oxidant injury on macrophage lipoprotein_lipase -LRB- LPL -RRB- production and sensitivity to LPL .
9034134	0	lipoprotein_lipase	23,41	LPL	43,46	lipoprotein lipase	LPL	16956(Tax:10090)	16956(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Prolactin 's effects on lipoprotein_lipase -LRB- LPL -RRB- activity and on LPL mRNA levels in cultured mouse mammary gland explants .
9714430	0	lipoprotein_lipase	31,49	LPL	51,54	lipoprotein lipase	LPL	4023	4023	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ile225Thr loop mutation in the lipoprotein_lipase -LRB- LPL -RRB- gene is a de novo event .
12882931	0	lipoprotein_lipase	17,35	Leptin	0,6	lipoprotein lipase	Leptin	4023	3952	Gene	Gene	secretion|amod|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	Leptin increases lipoprotein_lipase secretion by macrophages : involvement of oxidative stress and protein kinase C. Recent data suggest that plasma leptin may represent a cardiovascular_risk factor in diabetic patients .
21385844	0	lipoprotein_lipase	32,50	SorLA	0,5	lipoprotein lipase	SorLA	4023	6653	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	SorLA regulates the activity of lipoprotein_lipase by intracellular trafficking .
23794138	0	lipoprotein_lipase	33,51	THP-1	97,102	lipoprotein lipase	THP-1	4023	2736	Gene	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	Hydrolysis products generated by lipoprotein_lipase and endothelial_lipase differentially impact THP-1 macrophage cell signalling pathways .
25149060	0	lipoprotein_lipase	96,114	THP-1	129,134	lipoprotein lipase	THP-1	4023	2736	Gene	Gene	gene|amod|START_ENTITY targeting|dobj|gene targeting|nmod|macrophages macrophages|compound|END_ENTITY	MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein_lipase gene in human THP-1 macrophages .
16138264	0	lipoprotein_lipase	16,34	adiponectin	88,99	lipoprotein lipase	adiponectin	4023	9370	Gene	Gene	activity|amod|START_ENTITY Relationship|nmod|activity Relationship|acl|serum serum|dobj|levels levels|compound|END_ENTITY	Relationship of lipoprotein_lipase and hepatic_triacylglycerol_lipase activity to serum adiponectin levels in Japanese hyperlipidemic men .
21252727	0	lipoprotein_lipase	102,120	adiponectin	16,27	lipoprotein lipase	adiponectin	4023	9370	Gene	Gene	mutations|compound|START_ENTITY Contribution|nmod|mutations Contribution|nmod|END_ENTITY	Contribution of adiponectin to the cardiometabolic risk of postmenopausal women with loss-of-function lipoprotein_lipase gene mutations .
24905278	0	lipoprotein_lipase	49,67	adiponectin	15,26	lipoprotein lipase	adiponectin	16956(Tax:10090)	9370	Gene	Gene	START_ENTITY|nsubj|Association Association|nmod|END_ENTITY	Association of adiponectin with serum preheparin lipoprotein_lipase mass in women independent of fat mass and distribution , insulin resistance , and inflammation .
7516153	0	lipoprotein_lipase	11,29	alpha_2-macroglobulin	33,54	lipoprotein lipase	alpha 2-macroglobulin	4023	2	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of lipoprotein_lipase to alpha_2-macroglobulin .
25685701	0	lipoprotein_lipase	81,99	angiopoietin-like_4	24,43	lipoprotein lipase	angiopoietin-like 4	16956(Tax:10090)	57875(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY effects|nmod|activity effects|nmod|END_ENTITY	Differential effects of angiopoietin-like_4 in brain and muscle on regulation of lipoprotein_lipase activity .
3729948	0	lipoprotein_lipase	14,32	apolipoprotein_C-II	74,93	lipoprotein lipase	apolipoprotein C-II	4023	344	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of lipoprotein_lipase by N-alpha-palmitoyl -LRB- 56-79 -RRB- fragment of apolipoprotein_C-II .
3095375	1	lipoprotein_lipase	179,197	apolipoprotein_CIII	102,121	lipoprotein lipase	apolipoprotein CIII	4023	345	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Evidence that apolipoprotein_CIII inhibits catabolism of triglyceride-rich lipoproteins by lipoprotein_lipase in vivo .
17244606	0	lipoprotein_lipase	14,32	glucose-dependent_insulinotropic_polypeptide	36,80	lipoprotein lipase	glucose-dependent insulinotropic polypeptide	4023	2695	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of lipoprotein_lipase by glucose-dependent_insulinotropic_polypeptide in adipocytes .
17890220	0	lipoprotein_lipase	96,114	glucose-dependent_insulinotropic_polypeptide	30,74	lipoprotein lipase	glucose-dependent insulinotropic polypeptide	24539(Tax:10116)	25040(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity stimulation|amod|END_ENTITY	Resistin is a key mediator of glucose-dependent_insulinotropic_polypeptide -LRB- GIP -RRB- stimulation of lipoprotein_lipase -LRB- LPL -RRB- activity in adipocytes .
14564687	0	lipoprotein_lipase	51,69	hepatic_lipase	101,115	lipoprotein lipase	hepatic lipase	4023	3990	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	Interaction effect of Serine447Stop variant of the lipoprotein_lipase gene and C-514T variant of the hepatic_lipase gene on serum triglyceride levels in young adults : the Bogalusa Heart Study .
1657130	0	lipoprotein_lipase	141,159	hepatic_lipase	125,139	lipoprotein lipase	hepatic lipase	100340171(Tax:9986)	100008678(Tax:9986)	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Increased removal of beta-very low density lipoproteins after ethinyl_estradiol is associated with increased mRNA levels for hepatic_lipase , lipoprotein_lipase , and the low_density_lipoprotein_receptor in Watanabe_heritable_hyperlipidemic rabbits .
2025651	0	lipoprotein_lipase	43,61	interleukin-1	18,31	lipoprotein lipase	interleukin-1	4023	3552	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	Recombinant human interleukin-1 suppresses lipoprotein_lipase activity , but not expression of lipoprotein_lipase mRNA in mesenchymal rat heart cell cultures .
24905963	0	lipoprotein_lipase	45,63	lpl	65,68	lipoprotein lipase	lpl	30354(Tax:7955)	30354(Tax:7955)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Comparative studies of zebrafish Danio_rerio lipoprotein_lipase _ -LRB- lpl -RRB- _ and_hepatic_lipase -LRB- lipc -RRB- genes belonging to the lipase gene family : evolution and expression pattern .
7527452	0	lipoprotein_lipase	60,78	tumor_necrosis_factor_alpha	13,40	lipoprotein lipase	tumor necrosis factor alpha	16956(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of tumor_necrosis_factor_alpha gene expression by lipoprotein_lipase requires protein_kinase_C activation .
8169531	0	lipoprotein_lipase	60,78	tumor_necrosis_factor_alpha	13,40	lipoprotein lipase	tumor necrosis factor alpha	16956(Tax:10090)	21926(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of tumor_necrosis_factor_alpha gene expression by lipoprotein_lipase .
7518435	0	lipoprotein_receptor-related_protein	43,79	LRP	81,84	lipoprotein receptor-related protein	LRP	4035	4035	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of the low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- in mammalian central neurons .
9350853	0	lipoprotein_receptor-related_protein	39,75	LRP	77,80	lipoprotein receptor-related protein	LRP	4035	4035	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No association between the low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- gene and late-onset Alzheimer 's _ disease in a community-based sample .
19608750	0	lipoprotein_receptor-related_protein	114,150	MMP-3	64,69	lipoprotein receptor-related protein	MMP-3	16971(Tax:10090)	17392(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|END_ENTITY	Tissue-type_plasminogen_activator -LRB- t-PA -RRB- induces stromelysin-1 -LRB- MMP-3 -RRB- in endothelial cells through activation of lipoprotein_receptor-related_protein .
16945147	0	lipoprotein_receptor-related_protein	71,107	Syndecan-1	0,10	lipoprotein receptor-related protein	Syndecan-1	4035	6382	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- - independent , non-clathrin-mediated pathway .
19608750	0	lipoprotein_receptor-related_protein	114,150	Tissue-type_plasminogen_activator	0,33	lipoprotein receptor-related protein	Tissue-type plasminogen activator	16971(Tax:10090)	18791(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Tissue-type_plasminogen_activator -LRB- t-PA -RRB- induces stromelysin-1 -LRB- MMP-3 -RRB- in endothelial cells through activation of lipoprotein_receptor-related_protein .
11839752	0	lipoprotein_receptor-related_protein	97,133	alpha_2-Macroglobulin	0,21	lipoprotein receptor-related protein	alpha 2-Macroglobulin	25167(Tax:10116)	24153(Tax:10116)	Gene	Gene	N-methyl-D-aspartate|nmod|START_ENTITY reduces|nmod|N-methyl-D-aspartate reduces|nsubj|exposure exposure|amod|END_ENTITY	alpha_2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein_receptor-related_protein in cultured hippocampal neurons .
11435418	1	lipoprotein_receptor-related_protein	106,142	alpha_2-macroglobulin	59,80	lipoprotein receptor-related protein	alpha 2-macroglobulin	4035	2	Gene	Gene	complex|nmod|START_ENTITY complex|amod|END_ENTITY	alpha_2-macroglobulin complex with low density lipoprotein_receptor-related_protein -LRB- LRP -RRB- .
1502153	0	lipoprotein_receptor-related_protein	156,192	alpha_2-macroglobulin	193,214	lipoprotein receptor-related protein	alpha 2-macroglobulin	4035	2	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein_receptor-related_protein / alpha_2-macroglobulin receptor .
1718973	0	lipoprotein_receptor-related_protein	59,95	alpha_2-macroglobulin	96,117	lipoprotein receptor-related protein	alpha 2-macroglobulin	4035	2	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	39-kDa protein modulates binding of ligands to low density lipoprotein_receptor-related_protein / alpha_2-macroglobulin receptor .
9045716	0	lipoprotein_receptor-related_protein	12,48	tissue-type_plasminogen_activator	77,110	lipoprotein receptor-related protein	tissue-type plasminogen activator	4035	5327	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	Low density lipoprotein_receptor-related_protein modulates the expression of tissue-type_plasminogen_activator in human colon fibroblasts .
25238221	0	lipoprotein_receptor-related_protein_1	30,68	LRP1	70,74	lipoprotein receptor-related protein 1	LRP1	4035	4035	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Role of rs1466535 low density lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- gene polymorphism in carotid artery_disease .
26398628	0	lipoxygenase	135,147	LOX	149,152	lipoxygenase	LOX	100037829(Tax:4577)	100037829(Tax:4577)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Resistance to Fusarium_verticillioides and fumonisin accumulation in maize inbred lines involves an earlier and enhanced expression of lipoxygenase -LRB- LOX -RRB- genes .
3144281	0	lipoxygenase	24,36	lipoxygenase	40,52	lipoxygenase	lipoxygenase	547836(Tax:3847)	547836(Tax:3847)	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic_acid .
3144281	0	lipoxygenase	40,52	lipoxygenase	24,36	lipoxygenase	lipoxygenase	547836(Tax:3847)	547836(Tax:3847)	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic_acid .
8804025	0	lissencephaly_gene_1	26,46	LIS-1	48,53	lissencephaly gene 1	LIS-1	5048	5048	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Molecular analysis of the lissencephaly_gene_1 -LRB- LIS-1 -RRB- in medulloblastomas .
15350756	0	liver-expressed_antimicrobial_peptide_2	47,86	LEAP-2	88,94	liver-expressed antimicrobial peptide 2	LEAP-2	100136189(Tax:8022)	100136189(Tax:8022)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Discovery and characterization of two types of liver-expressed_antimicrobial_peptide_2 -LRB- LEAP-2 -RRB- genes in rainbow_trout .
25331796	0	liver-intestine_cadherin	14,38	Cadherin_17	40,51	liver-intestine cadherin	Cadherin 17	1015	1015	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of liver-intestine_cadherin -LRB- Cadherin_17 -RRB- expression , ERK phosphorylation and WNT signaling in EPHB6 receptor-expressing MDA-MB-231 cells .
16772708	0	liver-type_fatty-acid-binding_protein	36,73	erythropoietin	10,24	liver-type fatty-acid-binding protein	erythropoietin	2168	2056	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of erythropoietin on urinary liver-type_fatty-acid-binding_protein in patients with chronic_renal_failure and anemia .
15663956	0	liver-type_glutaminase	26,48	LGA	50,53	liver-type glutaminase	LGA	27165	27165	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Lack of expression of the liver-type_glutaminase -LRB- LGA -RRB- mRNA in human malignant_gliomas .
19416695	0	liver_X_receptor	55,71	LXR	73,76	liver X receptor	LXR	100270809(Tax:8030)	100270809(Tax:8030)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Molecular cloning , tissue expression and regulation of liver_X_receptor -LRB- LXR -RRB- transcription factors of Atlantic_salmon -LRB- Salmo_salar -RRB- and rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- .
23732298	0	liver_X_receptor_a	31,49	CYP3A4	64,70	liver X receptor a	CYP3A4	10062	1576	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|expression expression|compound|END_ENTITY	Dual roles of nuclear receptor liver_X_receptor_a -LRB- LXRa -RRB- in the CYP3A4 expression in human hepatocytes as a positive and negative regulator .
24713062	0	liver_X_receptor_a	89,107	peroxisome_proliferator-activated_receptor_a	39,83	liver X receptor a	peroxisome proliferator-activated receptor a	10062	5465	Gene	Gene	heterodimerization|nmod|START_ENTITY heterodimerization|nmod|END_ENTITY	Ligand-regulated heterodimerization of peroxisome_proliferator-activated_receptor_a with liver_X_receptor_a .
10064080	0	liver_and_activation-regulated_chemokine	24,64	LARC	66,70	liver and activation-regulated chemokine	LARC	20297(Tax:10090)	20297(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Selective expression of liver_and_activation-regulated_chemokine -LRB- LARC -RRB- in intestinal epithelium in mice and humans .
11035086	0	liver_and_activation-regulated_chemokine	54,94	macrophage_inflammatory_protein-3_alpha	95,134	liver and activation-regulated chemokine	macrophage inflammatory protein-3 alpha	6364	6364	Gene	Gene	production|nmod|START_ENTITY production|dep|END_ENTITY	Regulated production and molecular diversity of human liver_and_activation-regulated_chemokine / macrophage_inflammatory_protein-3_alpha from normal and transformed cells .
11171094	0	liver_carnitine_palmitoyltransferase_I	32,70	L-CPT_I	77,84	liver carnitine palmitoyltransferase I	L-CPT I	12894(Tax:10090)	12894(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Long-chain fatty_acids regulate liver_carnitine_palmitoyltransferase_I gene -LRB- L-CPT_I -RRB- expression through a peroxisome-proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- - independent pathway .
12404231	0	liver_intestine-cadherin	15,39	CDX2	0,4	liver intestine-cadherin	CDX2	1015	1045	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CDX2 regulates liver_intestine-cadherin expression in normal and malignant colon epithelium and intestinal_metaplasia .
23572524	0	liver_kinase_B1	67,82	nischarin	25,34	liver kinase B1	nischarin	6794	11188	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Integrin-binding protein nischarin interacts with tumor suppressor liver_kinase_B1 -LRB- LKB1 -RRB- to regulate cell migration of breast epithelial cells .
22961990	0	liver_receptor_homolog-1	28,52	LRH-1	54,59	liver receptor homolog-1	LRH-1	2494	2494	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of a new class of liver_receptor_homolog-1 -LRB- LRH-1 -RRB- antagonists : virtual screening , synthesis and biological evaluation .
23000165	0	liver_receptor_homolog-1	38,62	OCT4	14,18	liver receptor homolog-1	OCT4	2494	5460	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of OCT4 gene expression by liver_receptor_homolog-1 in human embryonic_carcinoma cells .
16091743	0	liver_receptor_homolog-1	21,45	estrogen_receptor	52,69	liver receptor homolog-1	estrogen receptor	26424(Tax:10090)	2099	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	The nuclear receptor liver_receptor_homolog-1 is an estrogen_receptor target gene .
20607599	0	liver_receptor_homolog-1	4,28	estrogen_receptor	39,56	liver receptor homolog-1	estrogen receptor	2494	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The liver_receptor_homolog-1 regulates estrogen_receptor expression in breast_cancer cells .
12972592	0	liver_receptor_homolog_1	55,79	Pancreatic-duodenal_homeobox_1	0,30	liver receptor homolog 1	Pancreatic-duodenal homeobox 1	26424(Tax:10090)	18609(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Pancreatic-duodenal_homeobox_1 regulates expression of liver_receptor_homolog_1 during pancreas development .
19724862	0	livin	39,44	MycN	0,4	livin	MycN	79444	4613	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MycN is a transcriptional regulator of livin in neuroblastoma .
2999072	0	lon	31,34	lon	61,64	lon	lon	20466934	20466934	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Insertional mutagenesis of the lon gene in Escherichia_coli : lon is dispensable .
2999072	0	lon	61,64	lon	31,34	lon	lon	20466934	20466934	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Insertional mutagenesis of the lon gene in Escherichia_coli : lon is dispensable .
12406576	0	long_form_of_Sox5	49,66	L-SOX5	68,74	long form of Sox5	L-SOX5	6660	6660	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of the human long_form_of_Sox5 -LRB- L-SOX5 -RRB- gene .
11960981	0	long_transient_receptor_potential_channel_2	33,76	LTRPC2	78,84	long transient receptor potential channel 2	LTRPC2	7226	7226	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of the cation channel long_transient_receptor_potential_channel_2 -LRB- LTRPC2 -RRB- by hydrogen_peroxide .
23163652	0	loricrin	42,50	GATA-3	0,6	loricrin	GATA-3	4014	2625	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GATA-3 regulates differentiation-specific loricrin gene expression in keratinocytes .
8227315	0	low-affinity_nerve_growth_factor_receptor	44,85	Ciliary_neurotrophic_factor	0,27	low-affinity nerve growth factor receptor	Ciliary neurotrophic factor	24596(Tax:10116)	25707(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- promotes low-affinity_nerve_growth_factor_receptor and CD4 expression by rat CNS microglia .
8390628	0	low-affinity_nerve_growth_factor_receptor	72,113	LNGFR	115,120	low-affinity nerve growth factor receptor	LNGFR	24596(Tax:10116)	24596(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Nerve growth factor -LRB- NGF -RRB- , brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and low-affinity_nerve_growth_factor_receptor -LRB- LNGFR -RRB- mRNA levels in cultured rat Schwann cells ; differential time - and dose-dependent regulation by cAMP .
12028822	0	low-affinity_nerve_growth_factor_receptor	72,113	p75	58,61	low-affinity nerve growth factor receptor	p75	4804	11168	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Oxidative stress modulates tyrosine kinase receptor A and p75 receptor -LRB- low-affinity_nerve_growth_factor_receptor -RRB- expression in SHSY5Y neuroblastoma cells .
2471639	0	low-density-lipoprotein-receptor	14,46	insulin	55,62	low-density-lipoprotein-receptor	insulin	3949	3630	Gene	Gene	mRNA|amod|START_ENTITY Regulation|nmod|mRNA Regulation|nmod|END_ENTITY	Regulation of low-density-lipoprotein-receptor mRNA by insulin in human hepatoma Hep G2 cells .
10089402	0	low-density_lipoprotein-receptor	69,101	apolipoprotein_E	120,136	low-density lipoprotein-receptor	apolipoprotein E	3949	348	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density_lipoprotein-receptor binding region of apolipoprotein_E refined at 1.9 A .
17923100	0	low-density_lipoprotein_receptor	49,81	Apolipoprotein_E	0,16	low-density lipoprotein receptor	Apolipoprotein E	3949	348	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|xcomp|binding	Apolipoprotein_E isoform-specific binding to the low-density_lipoprotein_receptor .
22666465	0	low-density_lipoprotein_receptor	30,62	DJ-1	71,75	low-density lipoprotein receptor	DJ-1	16835(Tax:10090)	57320(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of low-density_lipoprotein_receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis .
22378787	0	low-density_lipoprotein_receptor	46,78	Fibroblast_growth_factor-21	0,27	low-density lipoprotein receptor	Fibroblast growth factor-21	3949	26291	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Fibroblast_growth_factor-21 -LRB- FGF21 -RRB- regulates low-density_lipoprotein_receptor -LRB- LDLR -RRB- levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 -LRB- Cnpy2 -RRB- / Mylip-interacting saposin-like protein -LRB- Msap -RRB- .
12759574	0	low-density_lipoprotein_receptor	25,57	Growth_hormone	0,14	low-density lipoprotein receptor	Growth hormone	16835(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Growth_hormone increases low-density_lipoprotein_receptor and HMG-CoA_reductase mRNA expression in mesangial cells .
8637440	0	low-density_lipoprotein_receptor	26,58	Growth_hormone	0,14	low-density lipoprotein receptor	Growth hormone	300438(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY normalizes|dobj|expression normalizes|nsubj|END_ENTITY	Growth_hormone normalizes low-density_lipoprotein_receptor gene expression in hypothyroid rats .
22378787	0	low-density_lipoprotein_receptor	46,78	LDLR	80,84	low-density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Fibroblast_growth_factor-21 -LRB- FGF21 -RRB- regulates low-density_lipoprotein_receptor -LRB- LDLR -RRB- levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 -LRB- Cnpy2 -RRB- / Mylip-interacting saposin-like protein -LRB- Msap -RRB- .
25349780	0	low-density_lipoprotein_receptor	32,64	LDLR	66,70	low-density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Quercetin-3-glucoside increases low-density_lipoprotein_receptor -LRB- LDLR -RRB- expression , attenuates proprotein_convertase_subtilisin / kexin_9 -LRB- PCSK9 -RRB- secretion , and stimulates LDL uptake by Huh7 human hepatocytes in culture .
17346883	0	low-density_lipoprotein_receptor	36,68	LRP	86,89	low-density lipoprotein receptor	LRP	16835(Tax:10090)	16971(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Estradiol replacement increases the low-density_lipoprotein_receptor related protein -LRB- LRP -RRB- in the mouse brain .
21294679	0	low-density_lipoprotein_receptor	73,105	activating_transcription_factor-3	25,58	low-density lipoprotein receptor	activating transcription factor-3	3949	467	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Organelle stress-induced activating_transcription_factor-3 downregulates low-density_lipoprotein_receptor expression in Sk-Hep1 human liver cells .
18068040	0	low-density_lipoprotein_receptor	130,162	apobec-1	116,124	low-density lipoprotein receptor	apobec-1	16835(Tax:10090)	11810(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in apobec-1 -LRB- - / - -RRB- / low-density_lipoprotein_receptor -LRB- - / - -RRB- mice .
12031600	0	low-density_lipoprotein_receptor	88,120	apolipoprotein_B	68,84	low-density lipoprotein receptor	apolipoprotein B	3949	338	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of an asparagine to lysine mutation at amino_acid 3516 of apolipoprotein_B on low-density_lipoprotein_receptor binding .
15059809	0	low-density_lipoprotein_receptor	116,148	apolipoprotein_E	96,112	low-density lipoprotein receptor	apolipoprotein E	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Lack of complement factor C3 , but not factor B , increases hyperlipidemia and atherosclerosis in apolipoprotein_E - / - low-density_lipoprotein_receptor - / - mice .
16297155	0	low-density_lipoprotein_receptor	72,104	apolipoprotein_E	52,68	low-density lipoprotein receptor	apolipoprotein E	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Immunoglobulin treatment reduces atherosclerosis in apolipoprotein_E - / - low-density_lipoprotein_receptor - / - mice via the complement system .
9889019	0	low-density_lipoprotein_receptor	10,42	familial_hypercholesterolemia	98,127	low-density lipoprotein receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|END_ENTITY	Two novel low-density_lipoprotein_receptor gene mutations -LRB- E397X and 347delGCC -RRB- in St. Petersburg familial_hypercholesterolemia .
12212791	0	low-density_lipoprotein_receptor-related_protein	16,64	A_beta	87,93	low-density lipoprotein receptor-related protein	A beta	100754427	351	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	The role of the low-density_lipoprotein_receptor-related_protein -LRB- LRP1 -RRB- in Alzheimer 's A_beta generation : development of a cell-based model system .
14623925	0	low-density_lipoprotein_receptor-related_protein-1	28,78	LRP-1	80,85	low-density lipoprotein receptor-related protein-1	LRP-1	299858(Tax:10116)	299858(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of the low-density_lipoprotein_receptor-related_protein-1 -LRB- LRP-1 -RRB- in rats with prostate_cancer .
12793904	0	low-density_lipoprotein_receptor-related_protein_1	6,56	LRP1	58,62	low-density lipoprotein receptor-related protein 1	LRP1	4035	4035	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	C766T low-density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- gene polymorphism and susceptibility to breast_cancer .
24139096	0	low-density_lipoprotein_receptor-related_protein_1	80,130	LRP1	132,136	low-density lipoprotein receptor-related protein 1	LRP1	4035	4035	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- expression .
19605848	0	low-density_lipoprotein_receptor-related_protein_1	53,103	Platelet_factor_4	0,17	low-density lipoprotein receptor-related protein 1	Platelet factor 4	16971(Tax:10090)	56744(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Platelet_factor_4 regulates megakaryopoiesis through low-density_lipoprotein_receptor-related_protein_1 -LRB- LRP1 -RRB- on megakaryocytes .
15178744	0	low-density_lipoprotein_receptor-related_protein_1	4,54	lactoferrin	83,94	low-density lipoprotein receptor-related protein 1	lactoferrin	4035	301034(Tax:10116)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	The low-density_lipoprotein_receptor-related_protein_1 is a mitogenic receptor for lactoferrin in osteoblastic cells .
18174661	0	low-density_lipoprotein_receptor-related_protein_2	23,73	LRP2	75,79	low-density lipoprotein receptor-related protein 2	LRP2	4036	4036	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Genetic association of low-density_lipoprotein_receptor-related_protein_2 -LRB- LRP2 -RRB- with plasma lipid levels .
15077203	0	low-density_lipoprotein_receptor-related_protein_5	21,71	LRP5	73,77	low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with variation in vertebral bone mass , vertebral bone size , and stature in whites .
15979013	0	low-density_lipoprotein_receptor-related_protein_5	18,68	LRP5	70,74	low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotypes of the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene : are they a risk factor in osteoarthritis ?
16723389	0	low-density_lipoprotein_receptor-related_protein_5	21,71	LRP5	73,77	low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with obesity phenotypes in a large family-based association study .
17306638	0	low-density_lipoprotein_receptor-related_protein_5	61,111	LRP5	118,122	low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a single-nucleotide variation -LRB- A1330V -RRB- in the low-density_lipoprotein_receptor-related_protein_5 gene -LRB- LRP5 -RRB- with bone_mineral_density in adult Japanese women .
18058054	0	low-density_lipoprotein_receptor-related_protein_5	21,71	LRP5	73,77	low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene are associated with peak bone mass in non-sedentary men : results from the Odense androgen study .
18073493	0	low-density_lipoprotein_receptor-related_protein_5	15,65	LRP5	67,71	low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Association of low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- promoter SNP with peak bone_mineral_density in Chinese women .
19571442	0	low-density_lipoprotein_receptor-related_protein_5	22,72	LRP5	74,78	low-density lipoprotein receptor-related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A1330V variant of the low-density_lipoprotein_receptor-related_protein_5 -LRB- LRP5 -RRB- gene decreases Wnt signaling and affects the total body bone_mineral_density in Japanese women .
20685197	0	low-density_receptor-related_protein_1	12,50	LRP1	52,56	low-density receptor-related protein 1	LRP1	4035	4035	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of low-density_receptor-related_protein_1 -LRB- LRP1 -RRB- as a competitive substrate of the amyloid_precursor_protein -LRB- APP -RRB- for BACE1 .
12438242	0	low-molecular-weight_protein_tyrosine_phosphatase	28,77	Beta-catenin	0,12	low-molecular-weight protein tyrosine phosphatase	Beta-catenin	52	1499	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Beta-catenin interacts with low-molecular-weight_protein_tyrosine_phosphatase leading to cadherin-mediated cell-cell adhesion increase .
2726768	0	low_density_lipoprotein-receptor	68,100	familial_hypercholesterolemia	135,164	low density lipoprotein-receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Identification of a point mutation in growth factor repeat C of the low_density_lipoprotein-receptor gene in a patient with homozygous familial_hypercholesterolemia that affects ligand binding and intracellular movement of receptors .
8415619	0	low_density_lipoprotein-receptor	132,164	growth_hormone	105,119	low density lipoprotein-receptor	growth hormone	300438(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Loss of resistance to dietary cholesterol in the rat after hypophysectomy : importance of the presence of growth_hormone for hepatic low_density_lipoprotein-receptor expression .
18272520	0	low_density_lipoprotein_receptor	36,68	ApoB	14,18	low density lipoprotein receptor	ApoB	16835(Tax:10090)	238055(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Regulation of ApoB secretion by the low_density_lipoprotein_receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB .
10456843	0	low_density_lipoprotein_receptor	112,144	Apolipoprotein_E	0,16	low density lipoprotein receptor	Apolipoprotein E	300438(Tax:10116)	25728(Tax:10116)	Gene	Gene	superfamily|compound|START_ENTITY members|nmod|superfamily mediated|nmod|members mediated|nsubjpass|stimulation stimulation|amod|END_ENTITY	Apolipoprotein_E peptide stimulation of rat ovarian theca cell androgen synthesis is mediated by members of the low_density_lipoprotein_receptor superfamily .
10884290	0	low_density_lipoprotein_receptor	18,50	Apolipoprotein_E	0,16	low density lipoprotein receptor	Apolipoprotein E	3949	348	Gene	Gene	interaction|compound|START_ENTITY END_ENTITY|dep|interaction	Apolipoprotein_E ; - low_density_lipoprotein_receptor interaction .
7700578	0	low_density_lipoprotein_receptor	116,148	Apolipoprotein_E	0,16	low density lipoprotein receptor	Apolipoprotein E	3949	348	Gene	Gene	pathway|nmod|START_ENTITY uptake|nmod|pathway END_ENTITY|dobj|uptake	Apolipoprotein_E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low_density_lipoprotein_receptor .
7686151	0	low_density_lipoprotein_receptor	34,66	Glycoprotein_330	0,16	low density lipoprotein receptor	Glycoprotein 330	3949	4036	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Glycoprotein_330 , a member of the low_density_lipoprotein_receptor family , binds lipoprotein_lipase in vitro .
8767445	0	low_density_lipoprotein_receptor	59,91	LDL-R	93,98	low density lipoprotein receptor	LDL-R	3949	3949	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Rapid characterization of disease-causing mutations in the low_density_lipoprotein_receptor -LRB- LDL-R -RRB- gene by overexpression in COS cells .
15330118	0	low_density_lipoprotein_receptor	43,75	LDLR	77,81	low density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evolution of a hypervariable region of the low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene in humans and other hominoids .
17399720	0	low_density_lipoprotein_receptor	31,63	LDLR	65,69	low density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Two new large deletions in the low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene not revealed by PCR-based molecular diagnosis of familial_hypercholesterolemia .
22875854	0	low_density_lipoprotein_receptor	96,128	LDLR	130,134	low density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	Loss - and gain-of-function PCSK9 variants : cleavage specificity , dominant negative effects , and low_density_lipoprotein_receptor -LRB- LDLR -RRB- degradation .
24529145	0	low_density_lipoprotein_receptor	21,53	LDLR	55,59	low density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Presence and type of low_density_lipoprotein_receptor -LRB- LDLR -RRB- mutation influences the lipid profile and response to lipid-lowering therapy in Brazilian patients with heterozygous familial_hypercholesterolemia .
7868136	0	low_density_lipoprotein_receptor	54,86	LDLR	88,92	low density lipoprotein receptor	LDLR	3949	3949	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new restriction-site polymorphism in exon 18 of the low_density_lipoprotein_receptor -LRB- LDLR -RRB- gene .
14978770	0	low_density_lipoprotein_receptor	40,72	LDLr	74,78	low density lipoprotein receptor	LDLr	16835(Tax:10090)	16835(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Non-physiological overexpression of the low_density_lipoprotein_receptor -LRB- LDLr -RRB- gene in the liver induces pathological intracellular lipid and cholesterol storage .
15276231	0	low_density_lipoprotein_receptor	65,97	ORL1	99,103	low density lipoprotein receptor	ORL1	3949	4987	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between polymorphisms in the lectin-like oxidised low_density_lipoprotein_receptor -LRB- ORL1 -RRB- gene on chromosome 12 and Alzheimer 's _ disease in a UK cohort .
7696181	0	low_density_lipoprotein_receptor	23,55	Oncostatin_M	0,12	low density lipoprotein receptor	Oncostatin M	3949	5008	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Oncostatin_M activates low_density_lipoprotein_receptor gene transcription in sterol-repressed liver cells .
17449864	0	low_density_lipoprotein_receptor	29,61	PCSK9	9,14	low density lipoprotein receptor	PCSK9	3949	255738	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Secreted PCSK9 downregulates low_density_lipoprotein_receptor through receptor-mediated endocytosis .
26085104	0	low_density_lipoprotein_receptor	92,124	PCSK9	66,71	low density lipoprotein receptor	PCSK9	16835(Tax:10090)	100102(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY degradation|compound|END_ENTITY	Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low_density_lipoprotein_receptor degradation but interact with each other .
8910522	0	low_density_lipoprotein_receptor	47,79	Receptor-associated_protein	0,27	low density lipoprotein receptor	Receptor-associated protein	3949	4043	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	Receptor-associated_protein and members of the low_density_lipoprotein_receptor family share a common epitope .
3767991	0	low_density_lipoprotein_receptor	18,50	apolipoprotein_B-100	76,96	low density lipoprotein receptor	apolipoprotein B-100	3949	338	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	Identification of low_density_lipoprotein_receptor binding domains of human apolipoprotein_B-100 : a proposed consensus LDL_receptor binding sequence of apoB-100 .
10906325	0	low_density_lipoprotein_receptor	41,73	apolipoprotein_E	98,114	low density lipoprotein receptor	apolipoprotein E	3949	348	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The lipid-associated conformation of the low_density_lipoprotein_receptor binding domain of human apolipoprotein_E .
11546779	0	low_density_lipoprotein_receptor	129,161	apolipoprotein_E	74,90	low density lipoprotein receptor	apolipoprotein E	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY independent|nmod|presence independent|nsubj|Stimulation Stimulation|nmod|production production|nmod|lipoproteins lipoproteins|nmod|END_ENTITY	Stimulation of the in vivo production of very low density lipoproteins by apolipoprotein_E is independent of the presence of the low_density_lipoprotein_receptor .
15888448	0	low_density_lipoprotein_receptor	4,36	apolipoprotein_E	100,116	low density lipoprotein receptor	apolipoprotein E	3949	11816(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The low_density_lipoprotein_receptor regulates the level of central nervous system human and murine apolipoprotein_E but does not modify amyloid plaque pathology in PDAPP mice .
17079229	0	low_density_lipoprotein_receptor	68,100	apolipoprotein_E	27,43	low density lipoprotein receptor	apolipoprotein E	3949	348	Gene	Gene	ability|compound|START_ENTITY correlates|nmod|ability correlates|nsubj|extension extension|nmod|helix helix|compound|END_ENTITY	Lipid-induced extension of apolipoprotein_E helix 4 correlates with low_density_lipoprotein_receptor binding ability .
8051153	0	low_density_lipoprotein_receptor	72,104	apolipoprotein_E	18,34	low density lipoprotein receptor	apolipoprotein E	3949	348	Gene	Gene	binding|nmod|START_ENTITY mediates|xcomp|binding peptide|ccomp|mediates peptide|nsubj|END_ENTITY	A nonexchangeable apolipoprotein_E peptide that mediates binding to the low_density_lipoprotein_receptor .
9664080	0	low_density_lipoprotein_receptor	24,56	apolipoprotein_E	86,102	low density lipoprotein receptor	apolipoprotein E	16835(Tax:10090)	11816(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY lowering|nmod|mice lowering|advcl|overexpressing overexpressing|dobj|END_ENTITY	Cholesterol lowering in low_density_lipoprotein_receptor knockout mice overexpressing apolipoprotein_E .
9748256	0	low_density_lipoprotein_receptor	4,36	apolipoprotein_E	60,76	low density lipoprotein receptor	apolipoprotein E	3949	348	Gene	Gene	START_ENTITY|dep|conformation conformation|nmod|END_ENTITY	The low_density_lipoprotein_receptor active conformation of apolipoprotein_E .
2244888	0	low_density_lipoprotein_receptor	65,97	cachectin	32,41	low density lipoprotein receptor	cachectin	3949	7124	Gene	Gene	activity|nmod|START_ENTITY END_ENTITY|nmod|activity	Effect of tumor_necrosis_factor / cachectin on the activity of the low_density_lipoprotein_receptor on human skin fibroblasts .
11642133	0	low_density_lipoprotein_receptor	52,84	familial_hypercholesterolemia	102,131	low density lipoprotein receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	-LSB- Four new mutations and polymorphic variants of the low_density_lipoprotein_receptor in patients with familial_hypercholesterolemia in Saint Petersburg -RSB- .
18247305	0	low_density_lipoprotein_receptor	47,79	familial_hypercholesterolemia	85,114	low density lipoprotein receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Mutation screening and functional analysis of low_density_lipoprotein_receptor in a familial_hypercholesterolemia family -RSB- .
1911722	0	low_density_lipoprotein_receptor	179,211	familial_hypercholesterolemia	220,249	low density lipoprotein receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Serum low density lipoprotein cholesterol level and cholesterol absorption efficiency are influenced by apolipoprotein_B and E polymorphism and by the FH-Helsinki mutation of the low_density_lipoprotein_receptor gene in familial_hypercholesterolemia .
8168830	0	low_density_lipoprotein_receptor	46,78	familial_hypercholesterolemia	104,133	low density lipoprotein receptor	familial hypercholesterolemia	3949	3949	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	A new missense mutation -LRB- Cys297 -- > Phe -RRB- of the low_density_lipoprotein_receptor in Italian patients with familial_hypercholesterolemia -LRB- FHTrieste -RRB- .
9624172	0	low_density_lipoprotein_receptor	140,172	interleukin-1beta	81,98	low density lipoprotein receptor	interleukin-1beta	3949	3553	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Differential roles of extracellular_signal-regulated_kinase-1 / 2 and p38 -LRB- MAPK -RRB- in interleukin-1beta - and tumor_necrosis_factor-alpha-induced low_density_lipoprotein_receptor expression in HepG2 cells .
3476117	0	low_density_lipoprotein_receptor	24,56	low_density_lipoprotein_receptor	76,108	low density lipoprotein receptor	low density lipoprotein receptor	3949	3949	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of acetylated low_density_lipoprotein_receptor and suppression of low_density_lipoprotein_receptor on the cells of human monocytic_leukemia cell line -LRB- THP-1 cell -RRB- .
3476117	0	low_density_lipoprotein_receptor	76,108	low_density_lipoprotein_receptor	24,56	low density lipoprotein receptor	low density lipoprotein receptor	3949	3949	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of acetylated low_density_lipoprotein_receptor and suppression of low_density_lipoprotein_receptor on the cells of human monocytic_leukemia cell line -LRB- THP-1 cell -RRB- .
1618817	0	low_density_lipoprotein_receptor	13,45	tumor_necrosis_factor	81,102	low density lipoprotein receptor	tumor necrosis factor	3949	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of low_density_lipoprotein_receptor and a transcription factor SP-1 by tumor_necrosis_factor in human microvascular endothelial cells .
15172977	0	low_density_lipoprotein_receptor-related_protein_1B	22,73	LRP1B	75,80	low density lipoprotein receptor-related protein 1B	LRP1B	53353	53353	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Frequent silencing of low_density_lipoprotein_receptor-related_protein_1B -LRB- LRP1B -RRB- expression by genetic and epigenetic mechanisms in esophageal_squamous_cell_carcinoma .
17319939	0	low_density_lipoprotein_receptor-related_protein_4	61,111	LRP4	118,122	low density lipoprotein receptor-related protein 4	LRP4	504317(Tax:9913)	504317(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Congenital_syndactyly in cattle : four novel mutations in the low_density_lipoprotein_receptor-related_protein_4 gene -LRB- LRP4 -RRB- .
16434236	0	low_density_lipoprotein_receptor-related_protein_4	14,64	Lrp4	66,70	low density lipoprotein receptor-related protein 4	Lrp4	228357(Tax:10090)	228357(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of low_density_lipoprotein_receptor-related_protein_4 -LRB- Lrp4 -RRB- gene in the mouse germ cells .
23306204	0	low_density_lipoprotein_receptor-related_protein_6	15,65	SOX9	0,4	low density lipoprotein receptor-related protein 6	SOX9	4040	6662	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SOX9 regulates low_density_lipoprotein_receptor-related_protein_6 -LRB- LRP6 -RRB- and T-cell_factor_4 -LRB- TCF4 -RRB- expression and Wnt/b-catenin activation in breast_cancer .
11793484	0	low_density_lipoprotein_receptor_related_protein_5	43,93	LRP5	95,99	low density lipoprotein receptor related protein 5	LRP5	4041	4041	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Seven novel sequence variants in the human low_density_lipoprotein_receptor_related_protein_5 -LRB- LRP5 -RRB- gene .
16944024	0	low_molecular_mass_polypeptide_2	67,99	LMP2	101,105	low molecular mass polypeptide 2	LMP2	16912(Tax:10090)	16912(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Dextran sulfate sodium-induced colitis is associated with enhanced low_molecular_mass_polypeptide_2 -LRB- LMP2 -RRB- expression and is attenuated in LMP2 knockout mice .
24905963	0	lpl	65,68	lipoprotein_lipase	45,63	lpl	lipoprotein lipase	30354(Tax:7955)	30354(Tax:7955)	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Comparative studies of zebrafish Danio_rerio lipoprotein_lipase _ -LRB- lpl -RRB- _ and_hepatic_lipase -LRB- lipc -RRB- genes belonging to the lipase gene family : evolution and expression pattern .
7578852	0	lpr	80,83	ornithine_decarboxylase	14,37	lpr	ornithine decarboxylase	14102(Tax:10090)	18263(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of ornithine_decarboxylase in the kidney of autoimmune mice with the lpr gene .
806824	0	lrf	48,51	luteinizing_hormone-releasing_factor	10,46	lrf	luteinizing hormone-releasing factor	117107(Tax:10116)	117107(Tax:10116)	Gene	Gene	Action|appos|START_ENTITY Action|nmod|END_ENTITY	Action of luteinizing_hormone-releasing_factor -LRB- lrf -RRB- in the initiation of lordosis_behavior in the estrone-primed ovariectomized female rat .
11798719	0	lrp	68,71	lung_resistance-related_protein	30,61	lrp	lung resistance-related protein	9961	9961	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The clinical significance of lung_resistance-related_protein gene -LRB- lrp -RRB- , multidrug_resistance-associated_protein gene -LRB- mrp -RRB- and mdr-1 / p170 expression in acute_leukemia -RSB- .
23725335	0	lsc-3	119,124	lsc3	131,135	lsc-3	lsc3	1187322(Tax:223283)	1187322(Tax:223283)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of conserved regions harboring catalytic triad residues of the levansucrase protein encoded by the lsc-3 gene -LRB- lsc3 -RRB- of Pseudomonas_syringae_pv .
23725335	0	lsc3	131,135	lsc-3	119,124	lsc3	lsc-3	1187322(Tax:223283)	1187322(Tax:223283)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Mutational analysis of conserved regions harboring catalytic triad residues of the levansucrase protein encoded by the lsc-3 gene -LRB- lsc3 -RRB- of Pseudomonas_syringae_pv .
19702511	0	lubricin	177,185	superficial_zone_protein	152,176	lubricin	superficial zone protein	10216	10216	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering : analysis of superficial_zone_protein / lubricin expression .
10623756	0	luman	19,24	VP16	73,77	luman	VP16	10488	3054	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Potential role for luman , the cellular homologue of herpes_simplex_virus VP16 -LRB- alpha gene trans-inducing factor -RRB- , in herpesvirus latency .
14565932	0	lung_Kruppel-like_factor	39,63	Kruppel-like_factor_2	65,86	lung Kruppel-like factor	Kruppel-like factor 2	10365	10365	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differential role for IL-7 in inducing lung_Kruppel-like_factor -LRB- Kruppel-like_factor_2 -RRB- expression by naive versus activated T cells .
12110277	0	lung_resistance-related_protein	12,43	LRP	45,48	lung resistance-related protein	LRP	9961	9961	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the lung_resistance-related_protein -LRB- LRP -RRB- in the drug sensitivity of cultured tumor cells .
15154630	0	lung_resistance-related_protein	39,70	LRP	72,75	lung resistance-related protein	LRP	9961	9961	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Expression and prognostic value of the lung_resistance-related_protein -LRB- LRP -RRB- in germ cell testicular_tumors .
17438350	0	lung_resistance-related_protein	42,73	LRP	75,78	lung resistance-related protein	LRP	9961	9961	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunolocalization and cell expression of lung_resistance-related_protein -LRB- LRP -RRB- in normal and tumoral human respiratory cells .
9311441	0	lung_resistance-related_protein	14,45	LRP	47,50	lung resistance-related protein	LRP	9961	9961	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of lung_resistance-related_protein -LRB- LRP -RRB- in initial and relapsed childhood acute_lymphoblastic_leukemia .
9436635	0	lung_resistance-related_protein	14,45	LRP	47,50	lung resistance-related protein	LRP	9961	9961	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of lung_resistance-related_protein -LRB- LRP -RRB- in non-small_cell_lung_carcinomas of smokers and non-smokers and its predictive value for doxorubicin_resistance .
9778689	0	lung_resistance-related_protein	23,54	LRP	18,21	lung resistance-related protein	LRP	9961	9961	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Activation of the LRP -LRB- lung_resistance-related_protein -RRB- gene by short-term exposure of human leukemia cells to phorbol_ester and cytarabine .
10971394	0	lung_resistance-related_protein	16,47	P-glycoprotein	118,132	lung resistance-related protein	P-glycoprotein	9961	5243	Gene	Gene	Significance|nmod|START_ENTITY Significance|nmod|END_ENTITY	Significance of lung_resistance-related_protein in the clinical outcome of acute leukaemic patients with reference to P-glycoprotein .
11798719	0	lung_resistance-related_protein	30,61	lrp	68,71	lung resistance-related protein	lrp	9961	9961	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The clinical significance of lung_resistance-related_protein gene -LRB- lrp -RRB- , multidrug_resistance-associated_protein gene -LRB- mrp -RRB- and mdr-1 / p170 expression in acute_leukemia -RSB- .
10697509	0	lung_resistance_protein	18,41	LRP	43,46	lung resistance protein	LRP	9961	9961	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the lung_resistance_protein -LRB- LRP -RRB- in primary breast_cancer .
19969624	0	lung_resistance_protein	14,37	MRP1	80,84	lung resistance protein	MRP1	9961	4363	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of lung_resistance_protein and multidrug_resistance-related_protein -LRB- MRP1 -RRB- in pediatric acute_lymphoblastic_leukemia .
11471858	0	lung_resistance_protein	43,66	demethylase	4,15	lung resistance protein	demethylase	9961	8932	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	DNA demethylase expression correlates with lung_resistance_protein expression in common epithelial ovarian_cancers .
18362472	0	lupin	35,40	IgE	20,23	lupin	IgE	51251	3497	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of IgE binding to lupin , peanut and almond with sera from lupin-allergic patients .
806824	0	luteinizing_hormone-releasing_factor	10,46	lrf	48,51	luteinizing hormone-releasing factor	lrf	117107(Tax:10116)	117107(Tax:10116)	Gene	Gene	Action|nmod|START_ENTITY Action|appos|END_ENTITY	Action of luteinizing_hormone-releasing_factor -LRB- lrf -RRB- in the initiation of lordosis_behavior in the estrone-primed ovariectomized female rat .
9459544	0	luteinizing_hormone-releasing_hormone	60,97	Fos	98,101	luteinizing hormone-releasing hormone	Fos	25194(Tax:10116)	314322(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Progesterone blockade of a luteinizing hormone surge blocks luteinizing_hormone-releasing_hormone Fos activation and activation of its preoptic area afferents .
9475384	0	luteinizing_hormone-releasing_hormone	25,62	Fos	14,17	luteinizing hormone-releasing hormone	Fos	100135531(Tax:10141)	100713572	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Expression of Fos within luteinizing_hormone-releasing_hormone neurons , in relation to the steroid-induced luteinizing hormone surge in guinea_pigs .
11903807	0	luteinizing_hormone-releasing_hormone	31,68	LH-RH	70,75	luteinizing hormone-releasing hormone	LH-RH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	analogue|nmod|START_ENTITY analogue|appos|END_ENTITY	Targeted cytotoxic analogue of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- only transiently decreases the gene expression of pituitary receptors for LH-RH .
19605087	0	luteinizing_hormone-releasing_hormone	21,58	LH-RH	60,65	luteinizing hormone-releasing hormone	LH-RH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Local degradation of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- in the rat central nervous system .
325980	0	luteinizing_hormone-releasing_hormone	47,84	LH-RH	86,91	luteinizing hormone-releasing hormone	LH-RH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Temporal changes in the hypothalamic and serum luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- levels and the circulating ovarian steroids during the rat oestrous cycle .
6095443	0	luteinizing_hormone-releasing_hormone	39,76	LH-RH	78,83	luteinizing hormone-releasing hormone	LH-RH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Identification and characterization of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- receptors in the endometrial tissue of pregnant rats .
6256722	0	luteinizing_hormone-releasing_hormone	67,104	LH-RH	106,111	luteinizing hormone-releasing hormone	LH-RH	2796	2796	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Minimal steric difference study of structural requirements for the luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- receptor .
773817	0	luteinizing_hormone-releasing_hormone	10,47	LH-RH	49,54	luteinizing hormone-releasing hormone	LH-RH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- on the multiunit activity of the arcuate nucleus in the proestrous rats .
782712	0	luteinizing_hormone-releasing_hormone	51,88	LH-RH	90,95	luteinizing hormone-releasing hormone	LH-RH	100135531(Tax:10141)	100135531(Tax:10141)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LH-RH -RRB- in the median eminence of the guinea_pig .
12127507	0	luteinizing_hormone-releasing_hormone	33,70	LHRH	72,76	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	A new class of potent nonpeptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists : design and synthesis of 2-phenylimidazo -LSB- 1,2-a -RSB- pyrimidin-5-ones .
1493257	0	luteinizing_hormone-releasing_hormone	23,60	LHRH	62,66	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Behavioural effects of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in rats .
15006412	0	luteinizing_hormone-releasing_hormone	55,92	LHRH	94,98	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Elimination of antibacterial activities of non-peptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists derived from erythromycin_A .
15664860	0	luteinizing_hormone-releasing_hormone	46,83	LHRH	85,89	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Benzimidazole derivatives as novel nonpeptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists .
15664861	0	luteinizing_hormone-releasing_hormone	46,83	LHRH	85,89	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Benzimidazole derivatives as novel nonpeptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists .
15837306	0	luteinizing_hormone-releasing_hormone	30,67	LHRH	69,73	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Benzimidazoles as non-peptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists .
1661880	0	luteinizing_hormone-releasing_hormone	36,73	LHRH	75,79	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Content and distribution pattern of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the hypothalamus of neonatally estrogenized female rats .
17216287	0	luteinizing_hormone-releasing_hormone	55,92	LHRH	94,98	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	QSAR models for predicting the activity of non-peptide luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- antagonists derived from erythromycin_A using quantum chemical properties .
1740548	0	luteinizing_hormone-releasing_hormone	35,72	LHRH	74,78	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the nervus terminalis and brain of the big brown bat , Eptesicus fuscus .
1846575	0	luteinizing_hormone-releasing_hormone	35,72	LHRH	74,78	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Blockade of central and peripheral luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors in neonatal rats with a potent LHRH-antagonist inhibits the morphofunctional development of the thymus and maturation of the cell-mediated and humoral immune responses .
1999181	0	luteinizing_hormone-releasing_hormone	12,49	LHRH	51,55	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Presence of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- mRNA in rat spleen lymphocytes .
2436893	0	luteinizing_hormone-releasing_hormone	67,104	LHRH	138,142	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	START_ENTITY|dep|replacement replacement|nmod|END_ENTITY	Pulsatile follicle-stimulating hormone secretion is independent of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- : pulsatile replacement of LHRH bioactivity in LHRH-immunoneutralized rats .
3036261	0	luteinizing_hormone-releasing_hormone	20,57	LHRH	59,63	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Absence of specific luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors in the ovaries of Djungarian hamsters -LRB- Phodopus sungorus -RRB- .
3149759	0	luteinizing_hormone-releasing_hormone	20,57	LHRH	59,63	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- neurons and fibers in the Formosan rock-monkey .
3283711	0	luteinizing_hormone-releasing_hormone	28,65	LHRH	67,71	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Proteolytic inactivation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- by the whole rat ovary in vitro .
3511544	0	luteinizing_hormone-releasing_hormone	6,43	LHRH	50,54	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human luteinizing_hormone-releasing_hormone gene -LRB- LHRH -RRB- is located on short arm of chromosome 8 -LRB- region 8p11 .2 -- p21 -RRB- .
3512631	0	luteinizing_hormone-releasing_hormone	35,72	LHRH	74,78	luteinizing hormone-releasing hormone	LHRH	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- pathways in the sheep brain during anestrus and the mid-luteal phase of the estrous cycle .
405202	0	luteinizing_hormone-releasing_hormone	20,57	LHRH	59,63	luteinizing hormone-releasing hormone	LHRH	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the hypothalamus of the rhesus_monkey .
6092043	0	luteinizing_hormone-releasing_hormone	75,112	LHRH	114,118	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Maternal modulation of infantile ovarian development and available ovarian luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors via milk LHRH .
6166655	0	luteinizing_hormone-releasing_hormone	35,72	LHRH	74,78	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in Vibratome-sectioned brain .
6263596	0	luteinizing_hormone-releasing_hormone	33,70	LHRH	72,76	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Dissociated changes of pituitary luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- receptors and responsiveness to the neurohormone induced by 17_beta-estradiol and LHRH in vivo in the rat .
6400339	0	luteinizing_hormone-releasing_hormone	35,72	LHRH	74,78	luteinizing hormone-releasing hormone	LHRH	14714(Tax:10090)	14714(Tax:10090)	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	An immunocytochemical study of the luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- system in the white-footed mouse : effect of blinding and melatonin .
7036108	0	luteinizing_hormone-releasing_hormone	44,81	LHRH	83,87	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence and localization of immunoreactive luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- within the olfactory bulbs of adult male and female rats .
7626711	0	luteinizing_hormone-releasing_hormone	14,51	LHRH	53,57	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- secretion by melatonin in the ewe .
7626716	0	luteinizing_hormone-releasing_hormone	14,51	LHRH	53,57	luteinizing hormone-releasing hormone	LHRH	443529(Tax:9940)	443529(Tax:9940)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- secretion by melatonin in the ewe .
780101	0	luteinizing_hormone-releasing_hormone	16,53	LHRH	55,59	luteinizing hormone-releasing hormone	LHRH	100135531(Tax:10141)	100135531(Tax:10141)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in the guinea_pig brain .
8778229	0	luteinizing_hormone-releasing_hormone	51,88	LHRH	90,94	luteinizing hormone-releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	The effect of castration on steady state levels of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- mRNA and proLHRH processing : time course study utilizing semi-quantitative reverse transcription/polymerase chain reaction .
9590126	0	luteinizing_hormone-releasing_hormone	29,66	LHRH	68,72	luteinizing hormone-releasing hormone	LHRH	2796	2796	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Growth-inhibitory effects of luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- agonists on xenografts of the DU 145 human androgen-independent prostate_cancer cell line in nude_mice .
3306435	0	luteinizing_hormone-releasing_hormone	41,78	Neuropeptide_Y	0,14	luteinizing hormone-releasing hormone	Neuropeptide Y	25194(Tax:10116)	24604(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Neuropeptide_Y stimulates the release of luteinizing_hormone-releasing_hormone from medial basal hypothalamus in vitro : modulation by ovarian hormones .
1824680	0	luteinizing_hormone-releasing_hormone	67,104	Prolactin	0,9	luteinizing hormone-releasing hormone	Prolactin	2796	5617	Gene	Gene	values|nmod|START_ENTITY values|amod|END_ENTITY	Prolactin and pituitary gonadotropin values and responses to acute luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- challenge in patients having long-term treatment with a depot LHRH analogue .
6347662	0	luteinizing_hormone-releasing_hormone	83,120	Prolactin	0,9	luteinizing hormone-releasing hormone	Prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	luteinizing|xcomp|START_ENTITY suppresses|xcomp|luteinizing suppresses|nsubj|END_ENTITY	Prolactin suppresses luteinizing hormone secretion and pituitary responsiveness to luteinizing_hormone-releasing_hormone by a direct action at the anterior pituitary .
1672042	0	luteinizing_hormone-releasing_hormone	52,89	epidermal_growth_factor	11,34	luteinizing hormone-releasing hormone	epidermal growth factor	2796	1950	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor and analogues of luteinizing_hormone-releasing_hormone and somatostatin on phosphorylation and dephosphorylation of tyrosine residues of specific protein substrates in various tumors .
7504265	0	luteinizing_hormone-releasing_hormone	102,139	galanin	91,98	luteinizing hormone-releasing hormone	galanin	25194(Tax:10116)	29141(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Neonatal imprinting predetermines the sexually dimorphic , estrogen-dependent expression of galanin in luteinizing_hormone-releasing_hormone neurons .
23280565	0	luteinizing_hormone-releasing_hormone	99,136	growth_hormone-releasing_hormone	47,79	luteinizing hormone-releasing hormone	growth hormone-releasing hormone	25194(Tax:10116)	2691	Gene	Gene	Mechanisms|nmod|START_ENTITY Mechanisms|nmod|END_ENTITY	Mechanisms of synergism between antagonists of growth_hormone-releasing_hormone and antagonists of luteinizing_hormone-releasing_hormone in shrinking experimental benign_prostatic_hyperplasia .
1407372	0	luteinizing_hormone-releasing_hormone	57,94	prolactin	15,24	luteinizing hormone-releasing hormone	prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	pituitary|nmod|START_ENTITY secretion|nmod|pituitary secretion|compound|END_ENTITY	Stimulation of prolactin secretion from rat pituitary by luteinizing_hormone-releasing_hormone : evidence against mediation by angiotensin_II acting through a -LRB- Sar1-Ala8 -RRB- - angiotensin_II-sensitive receptor .
19210377	0	luteinizing_hormone-releasing_hormone	110,147	prolactin	89,98	luteinizing hormone-releasing hormone	prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	release|xcomp|START_ENTITY release|nsubj|Effects Effects|nmod|responsiveness responsiveness|nmod|END_ENTITY	Effects of estrogen and ectopic pituitary transplants on the responsiveness of pituitary prolactin release to luteinizing_hormone-releasing_hormone and dopamine .
2205478	0	luteinizing_hormone-releasing_hormone	49,86	prolactin	13,22	luteinizing hormone-releasing hormone	prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Hypothalamic prolactin stimulates the release of luteinizing_hormone-releasing_hormone from male rat hypothalamus .
2893378	0	luteinizing_hormone-releasing_hormone	145,182	prolactin	14,23	luteinizing hormone-releasing hormone	prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	analogs|nmod|START_ENTITY Receptors|nmod|analogs Receptors|nmod|END_ENTITY	Receptors for prolactin , somatostatin , and luteinizing_hormone-releasing_hormone in experimental prostate_cancer after treatment with analogs of luteinizing_hormone-releasing_hormone and somatostatin .
3116573	0	luteinizing_hormone-releasing_hormone	38,75	prolactin	15,24	luteinizing hormone-releasing hormone	prolactin	2796	5617	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Abnormal serum prolactin responses to luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in patients with anorexia_nervosa and bulimia .
8633105	0	luteinizing_hormone-releasing_hormone	11,48	prolactin	62,71	luteinizing hormone-releasing hormone	prolactin	25194(Tax:10116)	24683(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of luteinizing_hormone-releasing_hormone on pulsatile prolactin secretion in adult hyperprolactinemic female rats .
2263621	0	luteinizing_hormone-releasing_hormone	66,103	transforming_growth_factor_alpha	15,47	luteinizing hormone-releasing hormone	transforming growth factor alpha	25194(Tax:10116)	24827(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of transforming_growth_factor_alpha in the release of luteinizing_hormone-releasing_hormone from the developing female hypothalamus .
10318795	0	luteinizing_hormone_beta	14,38	gonadotropin-releasing_hormone	47,77	luteinizing hormone beta	gonadotropin-releasing hormone	16866(Tax:10090)	14714(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Activation of luteinizing_hormone_beta gene by gonadotropin-releasing_hormone requires the synergy of early_growth_response-1_and_steroidogenic_factor-1 .
18647647	0	luteinizing_hormone_receptor	57,85	Arrestin-3	0,10	luteinizing hormone receptor	Arrestin-3	3973	409	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Arrestin-3 is essential for the activation of Fyn by the luteinizing_hormone_receptor -LRB- LHR -RRB- in MA-10 cells .
12021067	0	luteinizing_hormone_receptor	65,93	Early_growth_response_gene-1	0,28	luteinizing hormone receptor	Early growth response gene-1	25477(Tax:10116)	24330(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Early_growth_response_gene-1 regulates the expression of the rat luteinizing_hormone_receptor gene .
14666170	0	luteinizing_hormone_receptor	61,89	GATA-4	116,122	luteinizing hormone receptor	GATA-4	16867(Tax:10090)	14463(Tax:10090)	Gene	Gene	factors|compound|START_ENTITY factors|amod|END_ENTITY	Adrenocortical_tumorigenesis in transgenic_mice : the role of luteinizing_hormone_receptor and transcription factors GATA-4 and GATA-61 .
17337116	0	luteinizing_hormone_receptor	30,58	GATA-4	85,91	luteinizing hormone receptor	GATA-4	16867(Tax:10090)	14463(Tax:10090)	Gene	Gene	factors|compound|START_ENTITY factors|amod|END_ENTITY	Adrenocortical_tumorigenesis , luteinizing_hormone_receptor and transcription factors GATA-4 and GATA-6 .
21193408	0	luteinizing_hormone_receptor	66,94	LHR	96,99	luteinizing hormone receptor	LHR	3973	3973	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Coactivator function of positive_cofactor_4 -LRB- PC4 -RRB- in Sp1-directed luteinizing_hormone_receptor -LRB- LHR -RRB- gene transcription .
23096696	0	luteinizing_hormone_receptor	18,46	LHR	48,51	luteinizing hormone receptor	LHR	101113228	101113228	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the luteinizing_hormone_receptor -LRB- LHR -RRB- gene in ovine non-gonadal tissues during estrous cycle .
23376535	0	luteinizing_hormone_receptor	15,43	LHR	45,48	luteinizing hormone receptor	LHR	3973	3973	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Association of luteinizing_hormone_receptor -LRB- LHR -RRB- mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies .
9780317	0	luteinizing_hormone_receptor	14,42	insulin-like_growth_factor-I	62,90	luteinizing hormone receptor	insulin-like growth factor-I	16867(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of luteinizing_hormone_receptor gene expression by insulin-like_growth_factor-I in an immortalized murine Leydig tumor cell line -LRB- BLT-1 -RRB- It is postulated that insulin-like_growth_factor-I -LRB- IGF-I -RRB- , a 70-amino_acid mitogenic polypeptide , regulates Leydig cell steroidogenesis .
18494797	0	luteinizing_hormone_receptor	14,42	mevalonate_kinase	62,79	luteinizing hormone receptor	mevalonate kinase	25477(Tax:10116)	81727(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of luteinizing_hormone_receptor mRNA expression by mevalonate_kinase -- role of the catalytic center in mRNA recognition .
21193408	0	luteinizing_hormone_receptor	66,94	positive_cofactor_4	24,43	luteinizing hormone receptor	positive cofactor 4	3973	10923	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Coactivator function of positive_cofactor_4 -LRB- PC4 -RRB- in Sp1-directed luteinizing_hormone_receptor -LRB- LHR -RRB- gene transcription .
1092712	0	luteinizing_hormone_releasing_hormone	20,57	LH-RH	59,64	luteinizing hormone releasing hormone	LH-RH	2796	2796	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of synthetic luteinizing_hormone_releasing_hormone -LRB- LH-RH -RRB- on the release of gonadotropins in Cushing 's _ disease .
324526	0	luteinizing_hormone_releasing_hormone	15,52	LH-RH	54,59	luteinizing hormone releasing hormone	LH-RH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of luteinizing_hormone_releasing_hormone -LRB- LH-RH -RRB- in pregnant rats .
122596	0	luteinizing_hormone_releasing_hormone	14,51	LHRH	53,57	luteinizing hormone releasing hormone	LHRH	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- antiserum administration on gonadotropin secretion in the rhesus_monkey .
12384185	0	luteinizing_hormone_releasing_hormone	25,62	LHRH	64,68	luteinizing hormone releasing hormone	LHRH	2796	2796	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Enzymatic degradation of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- by mucosal homogenates from the intestine of the common_brushtail possum -LRB- Trichosurus_vulpecula -RRB- .
24014	0	luteinizing_hormone_releasing_hormone	24,61	LHRH	63,67	luteinizing hormone releasing hormone	LHRH	2796	2796	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Postnidatory effects of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- in hamsters .
3010923	0	luteinizing_hormone_releasing_hormone	35,72	LHRH	74,78	luteinizing hormone releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Autoradiographical localization of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- receptors on rat testicular intertubular cells fractionated on Percoll density gradients .
3019631	0	luteinizing_hormone_releasing_hormone	12,49	LHRH	51,55	luteinizing hormone releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- in milk .
3329439	0	luteinizing_hormone_releasing_hormone	14,51	LHRH	53,57	luteinizing hormone releasing hormone	LHRH	2796	2796	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- on steroidogenesis by the human luteal tissue .
6356168	0	luteinizing_hormone_releasing_hormone	13,50	LHRH	52,56	luteinizing hormone releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- on the behavioral effects of amphetamine in rats .
7724042	0	luteinizing_hormone_releasing_hormone	19,56	LHRH	58,62	luteinizing hormone releasing hormone	LHRH	25194(Tax:10116)	25194(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Melatonin inhibits luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- induction of LH release from fetal rat pituitary cells .
8126131	0	luteinizing_hormone_releasing_hormone	20,57	LHRH	59,63	luteinizing hormone releasing hormone	LHRH	2796	2796	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Predictive value of luteinizing_hormone_releasing_hormone -LRB- LHRH -RRB- bolus testing before and after 36-hour pulsatile LHRH administration in the differential diagnosis of constitutional_delay_of_puberty and male hypogonadotropic_hypogonadism .
18619506	0	luteinizing_hormone_releasing_hormone	46,83	LHRH-1	85,91	luteinizing hormone releasing hormone	LHRH-1	613033(Tax:9544)	613033(Tax:9544)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Postmenopausal increase in KiSS-1 , GPR54 , and luteinizing_hormone_releasing_hormone -LRB- LHRH-1 -RRB- mRNA in the basal hypothalamus of female rhesus_monkeys .
1905310	0	luteinizing_hormone_releasing_hormone	40,77	prolactin	8,17	luteinizing hormone releasing hormone	prolactin	2796	5617	Gene	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Blunted prolactin response to exogenous luteinizing_hormone_releasing_hormone in superovulated women .
20380705	0	lycopene_beta-cyclase	45,66	CYC-B	68,73	lycopene beta-cyclase	CYC-B	544104(Tax:4081)	543649(Tax:4081)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Isolation and functional characterization of lycopene_beta-cyclase -LRB- CYC-B -RRB- promoter from Solanum habrochaites .
7678616	1	lymph_node_homing_receptor	89,115	L-selectin	116,126	lymph node homing receptor	L-selectin	6402	6402	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	I. Differential regulation of the peripheral lymph_node_homing_receptor L-selectin on T cells during the virgin to memory cell transition .
1371790	0	lymph_node_homing_receptor	21,47	Leu_8	49,54	lymph node homing receptor	Leu 8	6402	6402	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of human lymph_node_homing_receptor -LRB- Leu_8 -RRB- with the TCR/CD3 complex .
1701799	0	lymph_node_homing_receptor	49,75	Leu_8	87,92	lymph node homing receptor	Leu 8	6402	6402	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Monoclonal antibody against the human peripheral lymph_node_homing_receptor homologue -LRB- Leu_8 -RRB- inhibits B cell differentiation but not B cell proliferation .
16569201	0	lymphatic_vascular_endothelial_hyaluronan_receptor-1	14,66	LYVE-1	68,74	lymphatic vascular endothelial hyaluronan receptor-1	LYVE-1	10894	10894	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of lymphatic_vascular_endothelial_hyaluronan_receptor-1 -LRB- LYVE-1 -RRB- in the human placenta .
16307483	0	lympho-epithelial_Kazal-type_inhibitor	73,111	kallikreins_5_and_7	20,39	lympho-epithelial Kazal-type inhibitor	kallikreins 5 and 7	11005	25818	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human kallikreins_5_and_7 by the serine protease inhibitor lympho-epithelial_Kazal-type_inhibitor -LRB- LEKTI -RRB- .
9890705	0	lymphocyte-specific_protein_1	28,57	LSP1	59,63	lymphocyte-specific protein 1	LSP1	4046	4046	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Developmental regulation of lymphocyte-specific_protein_1 -LRB- LSP1 -RRB- expression in thymus during human T-cell maturation .
15331563	0	lymphocyte-specific_protein_tyrosine_kinase	28,71	LCK	73,76	lymphocyte-specific protein tyrosine kinase	LCK	16818(Tax:10090)	16818(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis of the lymphocyte-specific_protein_tyrosine_kinase -LRB- LCK -RRB- gene in type 1 diabetes .
20971076	0	lymphocyte-specific_protein_tyrosine_kinase	8,51	LCK	53,56	lymphocyte-specific protein tyrosine kinase	LCK	3932	3932	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of lymphocyte-specific_protein_tyrosine_kinase -LRB- LCK -RRB- in the expansion of glioma-initiating cells by fractionated radiation .
26628998	0	lymphocyte-specific_protein_tyrosine_kinase	29,72	Lck	74,77	lymphocyte-specific protein tyrosine kinase	Lck	16818(Tax:10090)	16818(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of siRNA-mediated lymphocyte-specific_protein_tyrosine_kinase -LRB- Lck -RRB- inhibition on pulmonary_inflammation in a mouse model of asthma .
21234523	0	lymphocyte-specific_protein_tyrosine_kinase	60,103	Suppressor_of_cytokine_signaling_1	0,34	lymphocyte-specific protein tyrosine kinase	Suppressor of cytokine signaling 1	3932	8651	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Suppressor_of_cytokine_signaling_1 interacts with oncogenic lymphocyte-specific_protein_tyrosine_kinase .
10545478	0	lymphocyte_activation_gene-3	24,52	CD8	76,79	lymphocyte activation gene-3	CD8	3902	925	Gene	Gene	II|amod|START_ENTITY co-distributed|nsubjpass|II co-distributed|nmod|molecules molecules|compound|END_ENTITY	The MHC class II ligand lymphocyte_activation_gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes .
27053622	0	lymphocyte_activation_gene-3	24,52	CD8	73,76	lymphocyte activation gene-3	CD8	3902	925	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	-LSB- Elevated expression of lymphocyte_activation_gene-3 on peripheral blood CD8 -LRB- + -RRB- T lymphocytes in patients with chronic hepatitis_B_virus infection -RSB- .
9341765	0	lymphocyte_activation_gene-3	65,93	LAG-3	95,100	lymphocyte activation gene-3	LAG-3	3902	3902	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Opposite role for interleukin-4 and interferon-gamma on CD30 and lymphocyte_activation_gene-3 -LRB- LAG-3 -RRB- expression by activated naive T cells .
7673707	0	lymphocyte_chemoattractant_factor	31,64	CD8	70,73	lymphocyte chemoattractant factor	CD8	3603	925	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Histamine-induced secretion of lymphocyte_chemoattractant_factor from CD8 + T cells is independent of transcription and translation .
8598478	0	lymphocyte_chemoattractant_factor	20,53	CD8	81,84	lymphocyte chemoattractant factor	CD8	3603	925	Gene	Gene	Secretion|appos|START_ENTITY Secretion|nmod|cells cells|compound|END_ENTITY	Secretion of IL-16 -LRB- lymphocyte_chemoattractant_factor -RRB- from serotonin-stimulated CD8 + T cells in vitro .
23325550	0	lymphocyte_enhancer_factor_1	99,127	DNA-dependent_protein_kinase_catalytic_subunit	18,64	lymphocyte enhancer factor 1	DNA-dependent protein kinase catalytic subunit	51176	5591	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of DNA-dependent_protein_kinase_catalytic_subunit as a novel interaction partner of lymphocyte_enhancer_factor_1 .
2553807	0	lymphocyte_function-associated_antigen	69,107	LFA-1	109,114	lymphocyte function-associated antigen	LFA-1	3683	3683	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Heterogeneous distribution and transmembrane signaling properties of lymphocyte_function-associated_antigen -LRB- LFA-1 -RRB- in human lymphocyte subsets .
3065089	0	lymphocyte_function-associated_antigen-1	27,67	LFA-1	69,74	lymphocyte function-associated antigen-1	LFA-1	16414(Tax:10090)	16414(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Higher level expression of lymphocyte_function-associated_antigen-1 -LRB- LFA-1 -RRB- on in vivo natural killer cells .
8995416	0	lymphocyte_function-associated_antigen-1	106,146	telencephalin	55,68	lymphocyte function-associated antigen-1	telencephalin	3683	7087	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte_function-associated_antigen-1 .
15493273	0	lymphocyte_function-associated_antigen-one	42,84	Interleukin-2	0,13	lymphocyte function-associated antigen-one	Interleukin-2	3683	3558	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Interleukin-2 modulates the expression of lymphocyte_function-associated_antigen-one -LRB- LFA-1 -RRB- and p150 ,95 during the generation of lymphokine-activated killer -LRB- LAK -RRB- cells .
11120881	0	lymphocyte_function-associated_antigen_1	18,58	CD28	77,81	lymphocyte function-associated antigen 1	CD28	3683	940	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Costimulation via lymphocyte_function-associated_antigen_1 in the absence of CD28 ligation promotes anergy of naive CD4 + T cells .
8798624	0	lymphocyte_function-associated_antigen_1	83,123	ICAM-3	71,77	lymphocyte function-associated antigen 1	ICAM-3	3683	3385	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the binding site on intercellular_adhesion_molecule-3 -LRB- ICAM-3 -RRB- for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
24593905	0	lymphocyte_function-associated_antigen_1	129,169	LFA-1	171,176	lymphocyte function-associated antigen 1	LFA-1	3683	3683	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Application of encoded library technology -LRB- ELT -RRB- to a protein-protein interaction target : discovery of a potent class of integrin lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- antagonists .
2685124	0	lymphocyte_function-associated_antigen_1	27,67	LFA-1	69,74	lymphocyte function-associated antigen 1	LFA-1	16414(Tax:10090)	16414(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- on epidermotropic and non-epidermotropic T-cell clones .
2956113	0	lymphocyte_function-associated_antigen_1	21,61	LFA-1	63,68	lymphocyte function-associated antigen 1	LFA-1	3683	3683	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of monocyte lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- in accessory cell function .
3315233	0	lymphocyte_function-associated_antigen_1	68,108	intercellular_adhesion_molecule-1	9,42	lymphocyte function-associated antigen 1	intercellular adhesion molecule-1	3683	3383	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Purified intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- is a ligand for lymphocyte_function-associated_antigen_1 -LRB- LFA-1 -RRB- .
7561056	0	lymphocyte_function-associated_molecule-1	94,135	ICAM-1	153,159	lymphocyte function-associated molecule-1	ICAM-1	3683	3383	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Characterization of intercellular_adhesion_molecule-1 ectodomain -LRB- sICAM-1 -RRB- as an inhibitor of lymphocyte_function-associated_molecule-1 interaction with ICAM-1 .
11598192	0	lymphocyte_function_antigen-1	36,65	H-Ras	13,18	lymphocyte function antigen-1	H-Ras	3683	3265	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity END_ENTITY|nmod|regulation	Dual role of H-Ras in regulation of lymphocyte_function_antigen-1 activity by stromal cell-derived factor-1alpha : implications for leukocyte transmigration .
10099837	0	lymphocyte_function_associated_antigen-3	27,67	LFA-3	69,74	lymphocyte function associated antigen-3	LFA-3	965	965	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of lymphocyte_function_associated_antigen-3 -LRB- LFA-3 -RRB- at the blood-brain barrier .
19861271	0	lymphoid_enhancer-binding_factor_1	79,113	LEF-1	115,120	lymphoid enhancer-binding factor 1	LEF-1	51176	51176	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Functional study of the eukaryotic fluorescent expression vector of truncated lymphoid_enhancer-binding_factor_1 -LRB- LEF-1 -RRB- gene in SW480 cells -RSB- .
20128911	0	lymphoid_enhancer_factor-1	22,48	SLUG	0,4	lymphoid enhancer factor-1	SLUG	51176	6591	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	SLUG : a new target of lymphoid_enhancer_factor-1 in human osteoblasts .
2421884	0	lymphokine	41,51	interleukin_2	53,66	lymphokine	interleukin 2	3558	3558	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization and modulation of human lymphokine -LRB- interleukin_2 -RRB- activated killer cell induction .
9243099	0	lymphopenia	4,15	lyp	17,20	lymphopenia	lyp	246774(Tax:10116)	246774(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The lymphopenia -LRB- lyp -RRB- gene controls the intrathymic cytokine ratio in congenic BioBreeding rats .
10433555	0	lymphotactin	25,37	IL-2	94,98	lymphotactin	IL-2	6375	3558	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Expression of SCM-1alpha / lymphotactin and SCM-1beta in natural killer cells is upregulated by IL-2 and IL-12 .
17403668	0	lymphotactin_receptor	51,72	vCCL2	111,116	lymphotactin receptor	vCCL2	2829	4961514(Tax:37296)	Gene	Gene	targets|dobj|START_ENTITY targets|nmod|END_ENTITY	Kaposi_sarcoma-associated_herpes_virus targets the lymphotactin_receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3 .
20473944	0	lymphotoxin-a	37,50	Lymphotoxin-b_receptor	0,22	lymphotoxin-a	Lymphotoxin-b receptor	16992(Tax:10090)	17000(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Lymphotoxin-b_receptor activation by lymphotoxin-a -LRB- 1 -RRB- b -LRB- 2 -RRB- and LIGHT promotes tumor growth in an NFkB-dependent manner .
22298782	0	lymphotoxin-a	23,36	P2Y2	0,4	lymphotoxin-a	P2Y2	4049	5029	Gene	Gene	secretion|amod|START_ENTITY secretion|nummod|END_ENTITY	P2Y2 receptor-mediated lymphotoxin-a secretion regulates intercellular cell adhesion molecule-1 expression in vascular smooth muscle cells .
21482522	0	lymphotoxin-alpha	27,44	LTA	46,49	lymphotoxin-alpha	LTA	4049	4049	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Identification of a novel lymphotoxin-alpha -LRB- LTA -RRB- gene associated with ankylosing_spondylitis in Ningxia population -RSB- .
10415052	0	lymphotoxin-alpha	38,55	TNF-alpha	28,37	lymphotoxin-alpha	TNF-alpha	16992(Tax:10090)	21926(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic_candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida_albicans .
15052269	0	lymphotoxin-alpha	30,47	activated_B_cell_factor-1	51,76	lymphotoxin-alpha	activated B cell factor-1	4049	9242	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Allele-specific repression of lymphotoxin-alpha by activated_B_cell_factor-1 .
19726041	0	lymphotoxin-alpha	28,45	galectin-2	47,57	lymphotoxin-alpha	galectin-2	4049	3957	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Lack of association between lymphotoxin-alpha , galectin-2 polymorphisms and coronary_artery_disease : a meta-analysis .
11371414	0	lymphotoxin-alpha	41,58	tumor_necrosis_factor-alpha	12,39	lymphotoxin-alpha	tumor necrosis factor-alpha	4049	7124	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , lymphotoxin-alpha , tumor necrosis factor receptor II , and interleukin-6 polymorphisms in patients with idiopathic pulmonary_fibrosis .
17140746	0	lymphotoxin-alpha	18,35	tumor_necrosis_factor-beta	37,63	lymphotoxin-alpha	tumor necrosis factor-beta	4049	4049	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role of lymphotoxin-alpha -LRB- tumor_necrosis_factor-beta -RRB- in the development of schizophrenia .
12474234	0	lymphotoxin-beta	14,30	LT-beta	32,39	lymphotoxin-beta	LT-beta	4050	4050	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of lymphotoxin-beta -LRB- LT-beta -RRB- in chronic inflammatory conditions .
15034048	0	lymphotoxin-beta	30,46	TNF	0,3	lymphotoxin-beta	TNF	4050	7124	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	TNF and phorbol_esters induce lymphotoxin-beta expression through distinct pathways involving Ets and NF-kappa B family members .
19701890	0	lymphotoxin-beta_receptor	25,50	HVEM	11,15	lymphotoxin-beta receptor	HVEM	4055	8764	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for HVEM , but not lymphotoxin-beta_receptor , in LIGHT-induced tumor cell death and chemokine production .
20139367	0	lymphotoxin_beta-receptor	133,158	tumor_necrosis_factor_receptor-1	100,132	lymphotoxin beta-receptor	tumor necrosis factor receptor-1	17000(Tax:10090)	21937(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|amod|END_ENTITY	Mouse aorta smooth_muscle_cells differentiate into lymphoid tissue organizer-like cells on combined tumor_necrosis_factor_receptor-1 / lymphotoxin_beta-receptor NF-kappaB signaling .
12571250	0	lymphotoxin_beta_receptor	61,86	TRAF2	26,31	lymphotoxin beta receptor	TRAF2	4055	7186	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Endogenous association of TRAF2 , TRAF3 , cIAP1 , and Smac with lymphotoxin_beta_receptor reveals a novel mechanism of apoptosis .
20185819	0	lymphotoxin_beta_receptor	75,100	TRAF3	0,5	lymphotoxin beta receptor	TRAF3	4055	7187	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin_beta_receptor .
10415030	0	lyn	26,29	CD45	0,4	lyn	CD45	17096(Tax:10090)	19264(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells .
15922563	0	lyp	118,121	IDDM2	107,112	lyp	IDDM2	326380(Tax:10116)	326380(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 -LRB- the lyp gene -RRB- and partly associated with other genes in the BB rat background .
9243099	0	lyp	17,20	lymphopenia	4,15	lyp	lymphopenia	246774(Tax:10116)	246774(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The lymphopenia -LRB- lyp -RRB- gene controls the intrathymic cytokine ratio in congenic BioBreeding rats .
20610395	0	lysin_motif_receptor-like_kinase	4,36	CERK1	48,53	lysin motif receptor-like kinase	CERK1	816909(Tax:3702)	821717(Tax:3702)	Gene	Gene	protein|nsubj|START_ENTITY protein|advmod|END_ENTITY	The lysin_motif_receptor-like_kinase -LRB- LysM-RLK -RRB- CERK1 is a major chitin-binding protein in Arabidopsis_thaliana and subject to chitin-induced phosphorylation .
23508577	0	lysine-specific_demethylase-1	89,118	LSD1	120,124	lysine-specific demethylase-1	LSD1	23028	23028	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific_demethylase-1 -LRB- LSD1 -RRB- inhibitor in human acute_myeloid_leukemia cell lines .
24165091	0	lysine-specific_demethylase_1	26,55	LSD1	57,61	lysine-specific demethylase 1	LSD1	23028	23028	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Analysis of the levels of lysine-specific_demethylase_1 -LRB- LSD1 -RRB- mRNA in human ovarian_tumors and the effects of chemical LSD1 inhibitors in ovarian_cancer cell lines .
25036127	0	lysine-specific_demethylase_1	71,100	LSD1	108,112	lysine-specific demethylase 1	LSD1	23028	23028	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
27062244	0	lysine-specific_demethylase_1	19,48	LSD1	50,54	lysine-specific demethylase 1	LSD1	99982(Tax:10090)	99982(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Tranylcypromine , a lysine-specific_demethylase_1 -LRB- LSD1 -RRB- inhibitor , suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis .
25036127	0	lysine-specific_demethylase_1	71,100	TFPI-2	49,55	lysine-specific demethylase 1	TFPI-2	23028	7980	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
25036127	0	lysine-specific_demethylase_1	71,100	tissue_factor_pathway_inhibitor-2	14,47	lysine-specific demethylase 1	tissue factor pathway inhibitor-2	23028	7980	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
16754985	0	lysine_epsilon-aminotransferase	52,83	Rv3290c	85,92	lysine epsilon-aminotransferase	Rv3290c	887904(Tax:83332)	887904(Tax:83332)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression , purification and crystallization of lysine_epsilon-aminotransferase -LRB- Rv3290c -RRB- from Mycobacterium_tuberculosis_H37Rv .
17002884	0	lysophosphatidic_acid_acyltransferase	32,69	mTOR	100,104	lysophosphatidic acid acyltransferase	mTOR	129642	21977(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of a novel human lysophosphatidic_acid_acyltransferase , LPAAT-theta , which activates mTOR pathway .
21878565	0	lysophosphatidic_acid_receptor_1	75,107	LPA1	109,113	lysophosphatidic acid receptor 1	LPA1	1902	1902	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic_acid_receptor_1 -LRB- LPA1 -RRB- signaling .
26937138	0	lysophosphatidic_acid_receptor_2	41,73	Sphingosine_kinase_1	0,20	lysophosphatidic acid receptor 2	Sphingosine kinase 1	9170	8877	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Sphingosine_kinase_1 is upregulated with lysophosphatidic_acid_receptor_2 in human colorectal_cancer .
24828490	0	lysophosphatidic_acid_receptor_type_1	85,122	LPA1	124,128	lysophosphatidic acid receptor type 1	LPA1	1902	1902	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Identification of heparin-binding_EGF-like_growth_factor -LRB- HB-EGF -RRB- as a biomarker for lysophosphatidic_acid_receptor_type_1 -LRB- LPA1 -RRB- activation in human breast_and_prostate_cancers .
2160563	0	lysophospholipase	64,81	Charcot-Leyden_crystal_protein	32,62	lysophospholipase	Charcot-Leyden crystal protein	151056	1178	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of Charcot-Leyden_crystal_protein -LRB- lysophospholipase -RRB- to intracytoplasmic crystals in tumor cells of primary solid and papillary_epithelial_neoplasm_of_the_pancreas .
2455566	0	lysophospholipase	68,85	Charcot-Leyden_crystal_protein	36,66	lysophospholipase	Charcot-Leyden crystal protein	151056	1178	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural localization of the Charcot-Leyden_crystal_protein -LRB- lysophospholipase -RRB- to a distinct crystalloid-free granule population in mature human eosinophils .
21489790	0	lysophospholipase	34,51	autotaxin	66,75	lysophospholipase	autotaxin	151056	5168	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Aromatic phosphonates inhibit the lysophospholipase D activity of autotaxin .
20345607	0	lysophospholipase_2	33,52	Acyl-CoA-binding_protein_2	0,26	lysophospholipase 2	Acyl-CoA-binding protein 2	841709(Tax:3702)	828891(Tax:3702)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Acyl-CoA-binding_protein_2 binds lysophospholipase_2 and lysoPC to promote tolerance to cadmium-induced oxidative stress in transgenic Arabidopsis .
16671772	0	lysophospholipase_D	45,64	autotaxin	65,74	lysophospholipase D	autotaxin	5168	5168	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Fluorogenic phospholipid substrate to detect lysophospholipase_D / autotaxin activity .
23826410	0	lysosomal-associated_membrane_protein-1	18,57	LAMP-1	59,65	lysosomal-associated membrane protein-1	LAMP-1	3916	3916	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the lysosomal-associated_membrane_protein-1 -LRB- LAMP-1 -RRB- in astrocytomas .
22009753	0	lysosomal-associated_protein_multispanning_transmembrane_5	40,98	ITCH	27,31	lysosomal-associated protein multispanning transmembrane 5	ITCH	7805	83737	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	HECT-type ubiquitin ligase ITCH targets lysosomal-associated_protein_multispanning_transmembrane_5 -LRB- LAPTM5 -RRB- and prevents LAPTM5-mediated cell death .
24136225	0	lysosomal_acid_lipase	15,36	FoxO1	0,5	lysosomal acid lipase	FoxO1	3988	2308	Gene	Gene	START_ENTITY|nsubj|controls controls|amod|END_ENTITY	FoxO1 controls lysosomal_acid_lipase in adipocytes : implication of lipophagy during nutrient restriction and metformin treatment .
25620107	0	lysosomal_acid_lipase	52,73	LIPA	80,84	lysosomal acid lipase	LIPA	3988	3988	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression and functional characterization of human lysosomal_acid_lipase gene -LRB- LIPA -RRB- mutation responsible for cholesteryl_ester_storage_disease -LRB- CESD -RRB- phenotype .
8020990	0	lysosomal_acid_lipase	34,55	LIPA	62,66	lysosomal acid lipase	LIPA	3988	3988	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the human lysosomal_acid_lipase gene -LRB- LIPA -RRB- .
10358049	0	lysosomal_acid_lipase	55,76	gastric_lipase	27,41	lysosomal acid lipase	gastric lipase	3988	8513	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of human gastric_lipase and model of lysosomal_acid_lipase , two lipolytic enzymes of medical interest .
9192839	0	lysosomal_alpha-mannosidase	31,58	MANB	65,69	lysosomal alpha-mannosidase	MANB	4125	4125	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure of the human lysosomal_alpha-mannosidase gene -LRB- MANB -RRB- .
12950108	0	lysosomal_associated_membrane_protein	27,64	LAMP-1	66,72	lysosomal associated membrane protein	LAMP-1	3916	3916	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of lysosomal_associated_membrane_protein -LRB- LAMP-1 -RRB- during mammalian spermiogenesis .
14754907	0	lysosomal_phospholipase_A2	13,39	retinoid_X_receptor	52,71	lysosomal phospholipase A2	retinoid X receptor	23659	6256	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of lysosomal_phospholipase_A2 through the retinoid_X_receptor in THP-1 cells .
14695530	0	lysosomal_sialidase	28,47	NEU1	54,58	lysosomal sialidase	NEU1	4758	4758	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Five novel mutations in the lysosomal_sialidase gene -LRB- NEU1 -RRB- in type II_sialidosis patients and assessment of their impact on enzyme activity and intracellular targeting using adenovirus-mediated expression .
16216242	0	lysosomal_sialidase	33,52	neu1	54,58	lysosomal sialidase	neu1	18010(Tax:10090)	18010(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of MyoD-inducible lysosomal_sialidase -LRB- neu1 -RRB- inhibits myogenesis in C2C12 cells .
25739356	0	lysosome-associated_membrane_protein-1	84,122	p38	63,66	lysosome-associated membrane protein-1	p38	3916	1432	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Extracellular galectin-3 induces MMP9 expression by activating p38 MAPK pathway via lysosome-associated_membrane_protein-1 -LRB- LAMP1 -RRB- .
27069538	0	lysosome-associated_membrane_protein_3	22,60	LAMP3	62,67	lysosome-associated membrane protein 3	LAMP3	239739(Tax:10090)	239739(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The potential role of lysosome-associated_membrane_protein_3 -LRB- LAMP3 -RRB- on cardiac_remodelling .
16922949	0	lysozyme	77,85	Elastin	0,7	lysozyme	Elastin	4069	2006	Gene	Gene	role|nmod|START_ENTITY changes|dep|role changes|compound|END_ENTITY	Elastin changes during chronological and photo-ageing : the important role of lysozyme .
2669620	0	lysozyme	39,47	Lysozyme	0,8	lysozyme	Lysozyme	4069	4069	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Lysozyme and cancer : role of exogenous lysozyme as anticancer agent -LRB- review -RRB- .
7442124	0	lysozyme	102,110	Lysozyme	0,8	lysozyme	Lysozyme	100340903(Tax:9986)	100340903(Tax:9986)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Lysozyme activity in gastrointestinal and lymphoreticular tissues of rabbits_genetically_deficient in lysozyme .
7988497	0	lysozyme	16,24	MUC2	36,40	lysozyme	MUC2	4069	4583	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Distribution of lysozyme and mucin -LRB- MUC2 and MUC3 -RRB- mRNA in human bronchus .
23082910	0	lysozyme	106,114	TLR2	30,34	lysozyme	TLR2	100860864	100860747	Gene	Gene	secretion|amod|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of over-expression of TLR2 in transgenic goats on pathogen clearance and role of up-regulation of lysozyme secretion and infiltration of inflammatory cells .
3338296	0	lysozyme	105,113	adenosine_deaminase	58,77	lysozyme	adenosine deaminase	4069	100	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Diagnostic value of simultaneous determination of pleural adenosine_deaminase and pleural lysozyme/serum lysozyme ratio in pleural_effusions .
10417681	0	lysozyme	165,173	elastin	122,129	lysozyme	elastin	4069	2006	Gene	Gene	observation|amod|START_ENTITY observation|nmod|component component|amod|END_ENTITY	Degenerative processes of elastic fibers in sun-protected and sun-exposed skin : immunoelectron microscopic observation of elastin , fibrillin-1 , amyloid P component , lysozyme and alpha1-antitrypsin .
10417681	0	lysozyme	165,173	fibrillin-1	131,142	lysozyme	fibrillin-1	4069	2200	Gene	Gene	observation|amod|START_ENTITY observation|nmod|component component|amod|END_ENTITY	Degenerative processes of elastic fibers in sun-protected and sun-exposed skin : immunoelectron microscopic observation of elastin , fibrillin-1 , amyloid P component , lysozyme and alpha1-antitrypsin .
23252580	0	lysozyme	25,33	glucose_6-phosphate_dehydrogenase	35,68	lysozyme	glucose 6-phosphate dehydrogenase	781146(Tax:9913)	281179(Tax:9913)	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Chemical modification of lysozyme , glucose_6-phosphate_dehydrogenase , _ and_bovine_eye_lens_proteins induced by peroxyl radicals : role of oxidizable amino_acid residues .
20888931	0	lysyl_hydroxylase	47,64	dPlod	66,71	lysyl hydroxylase	dPlod	39265(Tax:7227)	39265(Tax:7227)	Gene	Gene	Characterisation|nmod|START_ENTITY END_ENTITY|nsubj|Characterisation	Characterisation of the Drosophila procollagen lysyl_hydroxylase , dPlod .
10874315	0	lysyl_hydroxylase_1	27,46	PLOD	53,57	lysyl hydroxylase 1	PLOD	5351	5351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the lysyl_hydroxylase_1 gene -LRB- PLOD -RRB- in six unrelated patients with Ehlers-Danlos_syndrome_type_VI : prenatal exclusion of this disorder in one family .
16139999	0	lysyl_hydroxylase_2	71,90	Interleukin_4	0,13	lysyl hydroxylase 2	Interleukin 4	5352	3565	Gene	Gene	expression|nmod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Interleukin_4 and prolonged hypoxia induce a higher gene expression of lysyl_hydroxylase_2 and an altered cross-link pattern : important pathogenetic steps in early and late stage of systemic_scleroderma ?
23395997	0	lysyl_oxidase	60,73	BMP4	34,38	lysyl oxidase	BMP4	16948(Tax:10090)	12159(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Induction of EMT-like response by BMP4 via up-regulation of lysyl_oxidase is required for adipocyte lineage commitment .
26908052	0	lysyl_oxidase	70,83	Forkhead_Box_F1	0,15	lysyl oxidase	Forkhead Box F1	4015	2294	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Forkhead_Box_F1 promotes breast_cancer cell migration by upregulating lysyl_oxidase and suppressing Smad2/3 signaling .
11005237	0	lysyl_oxidase	24,37	LOX	39,42	lysyl oxidase	LOX	4015	4015	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Selective expression of lysyl_oxidase -LRB- LOX -RRB- in the stromal reactions of broncho-pulmonary_carcinomas .
12685868	0	lysyl_oxidase	35,48	LOX	50,53	lysyl oxidase	LOX	16948(Tax:10090)	16948(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression analysis of recombinant lysyl_oxidase -LRB- LOX -RRB- in myofibroblastlike cells .
15488859	0	lysyl_oxidase	36,49	LOX	73,76	lysyl oxidase	LOX	4015	4015	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	High levels of homocysteine inhibit lysyl_oxidase -LRB- LOX -RRB- and downregulate LOX expression in vascular endothelial cells .
21546528	0	lysyl_oxidase	83,96	LOX	98,101	lysyl oxidase	LOX	4015	4015	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Transforming_growth_factor-beta induces extracellular matrix protein cross-linking lysyl_oxidase -LRB- LOX -RRB- genes in human trabecular meshwork cells .
22883193	0	lysyl_oxidase	14,27	LOX	29,32	lysyl oxidase	LOX	4015	4015	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|appos|END_ENTITY	-LSB- Mechanism of lysyl_oxidase -LRB- LOX -RRB- in breast_cancer invasion and metastasis -RSB- .
23748100	0	lysyl_oxidase	70,83	LOX	85,88	lysyl oxidase	LOX	4015	4015	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Gremlin utilizes canonical and non-canonical TGFb signaling to induce lysyl_oxidase -LRB- LOX -RRB- genes in human trabecular meshwork cells .
23970168	0	lysyl_oxidase	14,27	LOX	109,112	lysyl oxidase	LOX	4015	4015	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of lysyl_oxidase in human osteosarcoma and its clinical significance : a tumor suppressive role of LOX in human osteosarcoma cells .
24065528	0	lysyl_oxidase	23,36	LOX	38,41	lysyl oxidase	LOX	4015	4015	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association of lysyl_oxidase -LRB- LOX -RRB- gene polymorphisms with intracranial aneurysm in a south Indian population .
8095446	0	lysyl_oxidase	10,23	Lox	30,33	lysyl oxidase	Lox	16948(Tax:10090)	16948(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse lysyl_oxidase gene -LRB- Lox -RRB- resides on chromosome 18 .
20498644	0	lysyl_oxidase	20,33	Pdcd4	0,5	lysyl oxidase	Pdcd4	4015	27250	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Pdcd4 repression of lysyl_oxidase inhibits hypoxia-induced breast_cancer cell invasion .
17395448	0	lysyl_oxidase	85,98	TGF-beta1	102,111	lysyl oxidase	TGF-beta1	4015	7040	Gene	Gene	START_ENTITY|nmod|effects effects|compound|END_ENTITY	Regulation of elastin promoter by lysyl_oxidase and growth factors : cross control of lysyl_oxidase on TGF-beta1 effects .
21893029	0	lysyl_oxidase	35,48	TNF-a	0,5	lysyl oxidase	TNF-a	24914(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	TNF-a increases cardiac fibroblast lysyl_oxidase expression through TGF-b and PI3Kinase signaling pathways .
9081125	0	lysyl_oxidase	44,57	Transforming_growth_factor-beta_1	0,33	lysyl oxidase	Transforming growth factor-beta 1	24914(Tax:10116)	59086(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	Transforming_growth_factor-beta_1 increases lysyl_oxidase enzyme activity and mRNA in rat aortic smooth muscle cells .
17931358	0	lysyl_oxidase	7,20	focal_adhesion_kinase	43,64	lysyl oxidase	focal adhesion kinase	4015	5747	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Active lysyl_oxidase -LRB- LOX -RRB- correlates with focal_adhesion_kinase -LRB- FAK -RRB- / paxillin activation and migration in invasive astrocytes .
10022501	0	lysyl_oxidase-like	20,38	LOXL	45,49	lysyl oxidase-like	LOXL	16949(Tax:10090)	16949(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Coexpression of the lysyl_oxidase-like gene -LRB- LOXL -RRB- and the gene encoding type III procollagen in induced liver_fibrosis .
15609098	0	lysyl_oxidase-like	75,93	LOXL	95,99	lysyl oxidase-like	LOXL	16949(Tax:10090)	16949(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Comparative immunocytochemical localization of lysyl_oxidase -LRB- LOX -RRB- and the lysyl_oxidase-like -LRB- LOXL -RRB- proteins : changes in the expression of LOXL during development and growth of mouse tissues .
10773658	0	lysyl_oxidase-like	24,42	LOXL1	44,49	lysyl oxidase-like	LOXL1	4016	4016	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Physical linkage of the lysyl_oxidase-like -LRB- LOXL1 -RRB- gene to the PML gene on human chromosome 15q22 .
10842102	0	lysyl_oxidase-like_2	10,30	mLOXL2	37,43	lysyl oxidase-like 2	mLOXL2	94352(Tax:10090)	94352(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The mouse lysyl_oxidase-like_2 gene -LRB- mLOXL2 -RRB- maps to chromosome 14 and is highly expressed in skin , lung and thymus .
11334717	0	lysyl_oxidase-like_3	40,60	hLOXL3	67,73	lysyl oxidase-like 3	hLOXL3	84695	84695	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a human lysyl_oxidase-like_3 gene -LRB- hLOXL3 -RRB- .
17354256	0	lysyl_oxidase_like-4	48,68	LOXL4	70,75	lysyl oxidase like-4	LOXL4	84171	84171	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Selective upregulation and amplification of the lysyl_oxidase_like-4 -LRB- LOXL4 -RRB- gene in head_and_neck_squamous_cell_carcinoma .
12011100	0	m-Bop	0,5	skNAC	71,76	m-Bop	skNAC	12180(Tax:10090)	17938(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	m-Bop , a repressor protein essential for cardiogenesis , interacts with skNAC , a heart - and muscle-specific transcription factor .
12783889	0	m-Calpain	0,9	calcium-sensing_receptor	31,55	m-Calpain	calcium-sensing receptor	281662(Tax:9913)	281038(Tax:9913)	Gene	Gene	colocalizes|nsubj|START_ENTITY colocalizes|nmod|END_ENTITY	m-Calpain colocalizes with the calcium-sensing_receptor -LRB- CaR -RRB- in caveolae in parathyroid cells and participates in degradation of the CaR .
20089917	0	m-calpain	80,89	Brain-derived_neurotrophic_factor	0,33	m-calpain	Brain-derived neurotrophic factor	824	627	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor and epidermal_growth_factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation .
21849499	0	m-calpain	37,46	Selenoprotein_K	0,15	m-calpain	Selenoprotein K	12334(Tax:10090)	80795(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Selenoprotein_K is a novel target of m-calpain , and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages .
20070945	0	m-calpain	16,25	TRPM7	0,5	m-calpain	TRPM7	824	54822	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun_N-terminal_kinase .
20070945	0	m-calpain	16,25	TRPM7	0,5	m-calpain	TRPM7	824	54822	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun_N-terminal_kinase .
16310784	0	m-calpain	36,45	aquaporin_0	21,32	m-calpain	aquaporin 0	824	4284	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of human aquaporin_0 by m-calpain .
10814538	0	m-calpain	47,56	histidine_decarboxylase	4,27	m-calpain	histidine decarboxylase	29154(Tax:10116)	24443(Tax:10116)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Rat histidine_decarboxylase is a substrate for m-calpain in vitro .
10677567	0	m-calpain	69,78	presenilin-1	100,112	m-calpain	presenilin-1	824	5663	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Molecular interactions between presenilin and calpain : inhibition of m-calpain protease activity by presenilin-1 , 2 and cleavage of presenilin-1 by m - , mu-calpain .
22484155	0	mAKAP	91,96	MEF2	27,31	mAKAP	MEF2	11640(Tax:10090)	4205	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- tethering to muscle selective A-kinase anchoring protein -LRB- mAKAP -RRB- is necessary for myogenic differentiation .
22484155	0	mAKAP	91,96	Myocyte_enhancer_factor_2	0,25	mAKAP	Myocyte enhancer factor 2	11640(Tax:10090)	4205	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- tethering to muscle selective A-kinase anchoring protein -LRB- mAKAP -RRB- is necessary for myogenic differentiation .
9733792	0	mArnt	64,69	AhR	38,41	mArnt	AhR	11863(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Structure and expression of the mouse AhR nuclear translocator -LRB- mArnt -RRB- gene .
11981810	0	mCCL19	125,131	CCX-CKR	153,160	mCCL19	CCX-CKR	24047(Tax:10090)	51554	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Characterization of mouse CCX-CKR , a receptor for the lymphocyte-attracting chemokines TECK/mCCL25 , SLC/mCCL21 and MIP-3beta / mCCL19 : comparison to human CCX-CKR .
11981810	0	mCCL19	125,131	CCX-CKR	26,33	mCCL19	CCX-CKR	24047(Tax:10090)	252837(Tax:10090)	Gene	Gene	Characterization|dep|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of mouse CCX-CKR , a receptor for the lymphocyte-attracting chemokines TECK/mCCL25 , SLC/mCCL21 and MIP-3beta / mCCL19 : comparison to human CCX-CKR .
8662823	0	mCCR2	37,42	C-C_chemokines_JE_and_FIC	70,95	mCCR2	C-C chemokines JE and FIC	12772(Tax:10090)	20306(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|receptor receptor|nmod|END_ENTITY	Cloning and functional expression of mCCR2 , a murine receptor for the C-C_chemokines_JE_and_FIC .
22770519	0	mCD14	14,19	TNFa	29,33	mCD14	TNFa	12475(Tax:10090)	21926(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Inhibition of mCD14 inhibits TNFa secretion and NO production in RAW264 .7 cells stimulated by Brucella_melitensis_infection .
26986513	0	mCD40L	42,48	CD40L	35,40	mCD40L	CD40L	21947(Tax:10090)	959	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	NORE1A induction by membrane-bound CD40L -LRB- mCD40L -RRB- contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanism .
16889924	0	mCLK1	48,53	CLK-1	42,47	mCLK1	CLK-1	12747(Tax:10090)	175729(Tax:6239)	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Genetic and molecular characterization of CLK-1 / mCLK1 , a conserved determinant of the rate of aging .
22429321	0	mCRISP1	86,93	cysteine-rich_secretory_protein-1	51,84	mCRISP1	cysteine-rich secretory protein-1	11571(Tax:10090)	11571(Tax:10090)	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunogenicity study of plasmid DNA encoding mouse cysteine-rich_secretory_protein-1 -LRB- mCRISP1 -RRB- as a contraceptive vaccine .
10438528	0	mCtBP2	60,66	hFOG-2	0,6	mCtBP2	hFOG-2	13017(Tax:10090)	23414	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	hFOG-2 , a novel zinc finger protein , binds the co-repressor mCtBP2 and modulates GATA-mediated activation .
21849669	0	mDia1	40,45	ERK	92,95	mDia1	ERK	13367(Tax:10090)	5594	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Role of RhoA and its effectors ROCK and mDia1 in the modulation of deformation-induced FAK , ERK , p38 , and MLC motogenic signals in human Caco-2 intestinal epithelial cells .
16887337	0	mDia1	12,17	HAN11	0,5	mDia1	HAN11	13367(Tax:10090)	71833(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	HAN11 binds mDia1 and controls GLI1 transcriptional activity .
22179776	0	mDia1	0,5	IRSp53	48,54	mDia1	IRSp53	13367(Tax:10090)	10458	Gene	Gene	proteins|compound|START_ENTITY interact|nsubj|proteins interact|nmod|END_ENTITY	mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation .
15123714	0	mDia1	37,42	PKD2	0,4	mDia1	PKD2	13367(Tax:10090)	5311	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells : role of mDia1 IN PKD2 localization to mitotic spindles .
25447542	0	mDia1	7,12	Profilin1	56,65	mDia1	Profilin1	13367(Tax:10090)	18643(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Formin mDia1 , a downstream molecule of FMNL1 , regulates Profilin1 for actin assembly and spindle organization during mouse oocyte meiosis .
16511001	0	mDia1	40,45	RhoC	62,66	mDia1	RhoC	13367(Tax:10090)	389	Gene	Gene	purification|nmod|START_ENTITY purification|nmod|END_ENTITY	The purification and crystallization of mDia1 in complex with RhoC .
15668168	0	mDia2	52,57	Rif	22,25	mDia2	Rif	56419(Tax:10090)	54509	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	The Rho family GTPase Rif induces filopodia through mDia2 .
21397845	0	mDia3	26,31	Aurora_B	0,8	mDia3	Aurora B	54004(Tax:10090)	9212	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Aurora_B regulates formin mDia3 in achieving metaphase chromosome alignment .
21866269	0	mDia3	7,12	Aurora_B	33,41	mDia3	Aurora B	54004(Tax:10090)	9212	Gene	Gene	START_ENTITY|dep|target target|nmod|kinase kinase|compound|END_ENTITY	Formin mDia3 : A novel target for Aurora_B kinase .
8773591	0	mEPO	50,54	eosinophil_peroxidase	22,43	mEPO	eosinophil peroxidase	13856(Tax:10090)	13861(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning of the murine eosinophil_peroxidase gene -LRB- mEPO -RRB- : characterization of a conserved subgroup of mammalian hematopoietic peroxidases .
15058383	0	mEar_2	109,115	eosinophil-associated_ribonuclease_2	71,107	mEar 2	eosinophil-associated ribonuclease 2	13587(Tax:10090)	13587(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated_ribonuclease_2 -LRB- mEar_2 -RRB- gene .
10230502	0	mGBP3	82,87	guanylate-binding_protein_3	53,80	mGBP3	guanylate-binding protein 3	55932(Tax:10090)	55932(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Interferon-gamma and lipopolysaccharide induce mouse guanylate-binding_protein_3 -LRB- mGBP3 -RRB- expression in the murine macrophage cell line RAW264 .7 .
12653978	0	mGluR1	26,32	Homer1a	68,75	mGluR1	Homer1a	14799(Tax:10090)	9456	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in mouse cerebellar Purkinje neurons .
22520513	0	mGluR1	0,6	cystic_fibrosis_transmembrane_conductance_regulator	22,73	mGluR1	cystic fibrosis transmembrane conductance regulator	14799(Tax:10090)	1080	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	mGluR1 interacts with cystic_fibrosis_transmembrane_conductance_regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes .
11525421	0	mGluR4	58,64	GRM4	66,70	mGluR4	GRM4	14802(Tax:10090)	2914	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation screening of the metabotropic glutamate receptor mGluR4 -LRB- GRM4 -RRB- gene in patients with schizophrenia .
18715999	0	mGluR5	88,94	Calmodulin	0,10	mGluR5	Calmodulin	14805(Tax:10090)	808	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5 .
12802596	0	mGluR5	35,41	P2Y2	43,47	mGluR5	P2Y2	14805(Tax:10090)	29597(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Immunohistochemical expressions of mGluR5 , P2Y2 receptor , PLC-beta1 , and IP3R-I and - II in Merkel cells in rat sinus hair follicles .
11238713	0	mGluR5	96,102	dopamine_transporter	27,47	mGluR5	dopamine transporter	14805(Tax:10090)	24898(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Modulation of the neuronal dopamine_transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes .
26577667	0	mGluR5	42,48	p11	0,3	mGluR5	p11	14805(Tax:10090)	8909	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	p11 regulates the surface localization of mGluR5 .
26341144	0	mGluR5	131,137	p70s6k	176,182	mGluR5	p70s6k	14805(Tax:10090)	83840(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k .
25047565	0	mGluR7	27,33	Elfn1	0,5	mGluR7	Elfn1	14807(Tax:10090)	243312(Tax:10090)	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures .
18329248	0	mGluR7	54,60	GRM7	62,66	mGluR7	GRM7	14807(Tax:10090)	2917	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A polymorphism of the metabotropic glutamate receptor mGluR7 -LRB- GRM7 -RRB- gene is associated with schizophrenia .
10446181	0	mGrb10	0,6	Nedd4	22,27	mGrb10	Nedd4	14783(Tax:10090)	17999(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	mGrb10 interacts with Nedd4 .
22691943	0	mIGF-1	17,23	SIRT1	24,29	mIGF-1	SIRT1	16000(Tax:10090)	93759(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|induces induces|nsubj|signaling signaling|compound|END_ENTITY	Cardioprotective mIGF-1 / SIRT1 signaling induces hypertension , leukocytosis and fear response in mice .
25108014	0	mIGF-1	41,47	SIRT1	48,53	mIGF-1	SIRT1	16000(Tax:10090)	93759(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	The TRPA1 channel is a cardiac target of mIGF-1 / SIRT1 signaling .
18000168	0	mKng1	37,42	kininogen	19,28	mKng1	kininogen	16644(Tax:10090)	288001(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Deletion of murine kininogen gene 1 -LRB- mKng1 -RRB- causes loss of plasma kininogen and delays thrombosis .
18000168	0	mKng1	37,42	kininogen	66,75	mKng1	kininogen	16644(Tax:10090)	288001(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY Deletion|nmod|gene causes|nsubj|Deletion causes|dobj|loss loss|nmod|END_ENTITY	Deletion of murine kininogen gene 1 -LRB- mKng1 -RRB- causes loss of plasma kininogen and delays thrombosis .
10842102	0	mLOXL2	37,43	lysyl_oxidase-like_2	10,30	mLOXL2	lysyl oxidase-like 2	94352(Tax:10090)	94352(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The mouse lysyl_oxidase-like_2 gene -LRB- mLOXL2 -RRB- maps to chromosome 14 and is highly expressed in skin , lung and thymus .
23594158	0	mLST8	85,90	CAD	15,18	mLST8	CAD	56716(Tax:10090)	730249	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of CAD , a multifunctional protein involved in pyrimidine synthesis , with mLST8 , a component of the mTOR complexes .
17220594	0	mOat3	43,48	organic_anion_transporter_3	14,41	mOat3	organic anion transporter 3	19879(Tax:10090)	19879(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of mouse organic_anion_transporter_3 -LRB- mOat3 -RRB- as a basolateral prostaglandin_E2 transport pathway .
15014433	0	mPGES-1	70,77	COX-2	64,69	mPGES-1	COX-2	64292(Tax:10090)	19225(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|compound|END_ENTITY	Hyperplastic_gastric_tumors induced by activated macrophages in COX-2 / mPGES-1 transgenic_mice .
25108236	0	mPGES-1	97,104	EGR1	81,85	mPGES-1	EGR1	64292(Tax:10090)	1958	Gene	Gene	promoter|amod|START_ENTITY binding|nmod|promoter binding|nsubj|END_ENTITY	15d-PGJ decreases PGE synthesis in HBx-positive liver cells by interfering EGR1 binding to mPGES-1 promoter .
20398340	0	mPGES-1	130,137	JNK	16,19	mPGES-1	JNK	64292(Tax:10090)	5599	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression involved|nmod|regulation involved|nsubjpass|END_ENTITY	Signal pathways JNK and NF-kappaB , identified by global gene expression profiling , are involved in regulation of TNFalpha-induced mPGES-1 and COX-2 expression in gingival fibroblasts .
16204198	0	mPGES1	21,27	COX-1	12,17	mPGES1	COX-1	64292(Tax:10090)	17708(Tax:10090)	Gene	Gene	Coupling|nmod|START_ENTITY Coupling|nmod|END_ENTITY	Coupling of COX-1 to mPGES1 for prostaglandin_E2 biosynthesis in the murine mammary gland .
20412702	0	mPR3	23,27	proteinase_3	9,21	mPR3	proteinase 3	19152(Tax:10090)	5657	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Membrane proteinase_3 -LRB- mPR3 -RRB- expression on neutrophils is not increased in localized Wegener 's _ granulomatosis -LRB- WG -RRB- and Churg-Strauss_syndrome -LRB- CSS -RRB- .
24424068	0	mPRa	96,100	PGRMC1	181,187	mPRa	PGRMC1	20200(Tax:10090)	10857	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Enhancement of cell surface expression and receptor functions of membrane progestin receptor a -LRB- mPRa -RRB- by progesterone_receptor membrane component 1 -LRB- PGRMC1 -RRB- : evidence for a role of PGRMC1 as an adaptor protein for steroid receptors .
19616057	0	mPer1	13,18	GnRH	33,37	mPer1	GnRH	18626(Tax:10090)	2796	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of mPer1 expression by GnRH in pituitary gonadotrope cells involves EGR-1 .
11395012	0	mPer1	26,31	clock	71,76	mPer1	clock	18626(Tax:10090)	12753(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Differential functions of mPer1 , mPer2 , and mPer3 in the SCN circadian clock .
11606459	0	mPer1	65,70	clock	54,59	mPer1	clock	18626(Tax:10090)	12753(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Physical and inflammatory stressors elevate circadian clock gene mPer1 mRNA levels in the paraventricular nucleus of the mouse .
12387815	0	mPer2	126,131	CLOCK	11,16	mPer2	CLOCK	18627(Tax:10090)	12753(Tax:10090)	Gene	Gene	mRNAs|compound|START_ENTITY expression|nmod|mRNAs feeding|dep|expression clocks|nmod|feeding entrainment|nmod|clocks background|amod|entrainment involved|nmod|background involved|nsubjpass|END_ENTITY	Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding : entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl : ICR background .
12387815	0	mPer2	126,131	Clock	164,169	mPer2	Clock	18627(Tax:10090)	12753(Tax:10090)	Gene	Gene	mRNAs|compound|START_ENTITY mRNAs|nmod|heart heart|nmod|mice mice|amod|END_ENTITY	Functional CLOCK is not involved in the entrainment of peripheral clocks to the restricted feeding : entrainable expression of mPer2 and BMAL1 mRNAs in the heart of Clock mutant mice on Jcl : ICR background .
20472413	0	mPer2	11,16	Clock	0,5	mPer2	Clock	18627(Tax:10090)	12753(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	Clock gene mPer2 functions in diurnal variation of acetaminophen induced hepatotoxicity in mice .
11475423	0	mPer2	27,32	clock	43,48	mPer2	clock	18627(Tax:10090)	12753(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Impaired expression of the mPer2 circadian clock gene in the suprachiasmatic nuclei of aging mice .
22922482	0	mPrP	14,18	Prion_protein	0,13	mPrP	Prion protein	19122(Tax:10090)	5621	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Prion_protein mPrP -LSB- F175A -RSB- -LRB- 121-231 -RRB- : structure and stability in solution .
12586211	0	mREN2	115,120	TGR	111,114	mREN2	TGR	19702(Tax:10090)	232223(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Cardiovascular and renal effects of cyclooxygenase inhibition in transgenic rats harboring mouse renin-2 gene -LRB- TGR -LSB- mREN2 -RSB- 27 -RRB- .
8557967	0	mREN2	40,45	TGR	36,39	mREN2	TGR	19702(Tax:10090)	232223(Tax:10090)	Gene	Gene	27|appos|START_ENTITY 27|compound|END_ENTITY	Angiotensin_II receptor blockade in TGR -LRB- mREN2 -RRB- 27 : effects of renin-angiotensin-system gene expression and cardiovascular functions .
9605382	0	mREN2	78,83	TGR	74,77	mREN2	TGR	19702(Tax:10090)	232223(Tax:10090)	Gene	Gene	rats|dep|START_ENTITY END_ENTITY|xcomp|rats	Differential development of early hypertension in heterozygous transgenic TGR -LRB- mREN2 -RRB- 27 rats .
19358743	0	mRHBDD1	5,12	GC-1	0,4	mRHBDD1	GC-1	76867(Tax:10090)	14919(Tax:10090)	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	GC-1 mRHBDD1 knockdown spermatogonia cells lose their spermatogenic capacity in mouse seminiferous tubules .
9808774	0	mSLK	47,51	STE20	76,81	mSLK	STE20	20874(Tax:10090)	223255(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Identification and initial characterization of mSLK , a murine member of the STE20 family of kinases .
25738366	0	mSin1	19,24	mTORC1	58,64	mSin1	mTORC1	227743(Tax:10090)	382056(Tax:10090)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 .
11571228	0	mSin3	51,56	TGIF	37,41	mSin3	TGIF	20466(Tax:10090)	7050	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	The Smad transcriptional corepressor TGIF recruits mSin3 .
15467731	0	mSin3A	75,81	SYT	0,3	mSin3A	SYT	20466(Tax:10090)	6857	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SYT , a partner of SYT-SSX oncoprotein in synovial_sarcomas , interacts with mSin3A , a component of histone deacetylase complex .
7670467	0	mSos1	27,32	Grb2	4,8	mSos1	Grb2	20662(Tax:10090)	2885	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The Grb2 binding domain of mSos1 is not required for downstream signal transduction .
14576155	0	mTOR	70,74	AKT	0,3	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	inhibitors|appos|START_ENTITY mammalian_target_of_rapamycin|dobj|inhibitors determines|advcl|mammalian_target_of_rapamycin determines|nsubj|activity activity|compound|END_ENTITY	AKT activity determines sensitivity to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors by regulating cyclin_D1 and c-myc expression .
17016437	0	mTOR	38,42	AKT	0,3	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	inhibitors|compound|START_ENTITY ability|nmod|inhibitors regulates|dobj|ability regulates|nsubj|activity activity|compound|END_ENTITY	AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple_myeloma cells .
17804710	0	mTOR	84,88	AKT	115,118	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	kinase|compound|START_ENTITY vivo|nmod|kinase converge|nmod|vivo converge|advcl|activating activating|dobj|END_ENTITY	Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT .
18826385	0	mTOR	47,51	AKT	41,44	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|PTEN PTEN|dep|END_ENTITY	Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas .
19120326	0	mTOR	15,19	AKT	40,43	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002 .
21168265	0	mTOR	52,56	AKT	154,157	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	rapamycin|compound|START_ENTITY activity|nmod|rapamycin enhances|dobj|activity enhances|advcl|suppressing suppressing|dobj|signaling signaling|compound|END_ENTITY	Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast_cancer cell lines mainly by suppressing rapamycin-induced AKT signaling .
21909130	0	mTOR	114,118	AKT	0,3	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	targeting|dobj|START_ENTITY implications|acl|targeting absence|dep|implications induces|nmod|absence induces|nsubj|END_ENTITY	AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage : implications for targeting mTOR during malignancy .
21993994	0	mTOR	177,181	AKT	0,3	mTOR	AKT	21977(Tax:10090)	11651(Tax:10090)	Gene	Gene	way|nmod|START_ENTITY promotes|nmod|way promotes|nsubj|END_ENTITY	AKT -LRB- v-akt murine thymoma viral oncogene homolog 1 -RRB- and N-Ras -LRB- neuroblastoma ras viral oncogene homolog -RRB- coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR -LRB- mammalian target of rapamycin complex 1 -RRB- , FOXM1 -LRB- forkhead_box_M1 -RRB- / SKP2 , and c-Myc pathways .
24131573	0	mTOR	59,63	AKT	0,3	mTOR	AKT	21977(Tax:10090)	24185(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia .
24705275	0	mTOR	75,79	AKT	0,3	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	disruption|nmod|START_ENTITY signaling|nsubj|disruption promote|advcl|signaling inhibitors|xcomp|promote inhibitors|nsubj|END_ENTITY	AKT inhibitors promote cell death in cervical_cancer through disruption of mTOR signaling and glucose uptake .
25710488	0	mTOR	47,51	AKT	87,90	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	Activation|compound|START_ENTITY Growth|nmod|Activation Promotion|nmod|Growth Promotion|dep|Effects Effects|nmod|Stimulators Stimulators|compound|END_ENTITY	Promotion of Ovarian Follicle Growth following mTOR Activation : Synergistic Effects of AKT Stimulators .
26535060	0	mTOR	30,34	AKT	64,67	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	START_ENTITY|nmod|Well Well|nmod|Targeting Targeting|nmod|Signaling Signaling|compound|END_ENTITY	Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular_Carcinoma .
26824321	0	mTOR	27,31	AKT	68,71	mTOR	AKT	21977(Tax:10090)	207	Gene	Gene	signaling|compound|START_ENTITY regulation|nmod|signaling determines|nsubj|regulation determines|nmod|inhibition inhibition|compound|END_ENTITY	Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse_large_B_cell_lymphoma .
23524951	0	mTOR	0,4	AMBRA1	98,104	mTOR	AMBRA1	21977(Tax:10090)	55626	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	mTOR inhibits autophagy by controlling ULK1 ubiquitylation , self-association and function through AMBRA1 and TRAF6 .
12558800	0	mTOR	98,102	AMPK	57,61	mTOR	AMPK	21977(Tax:10090)	5563	Gene	Gene	AMP-activated_protein_kinase|appos|START_ENTITY AMP-activated_protein_kinase|appos|END_ENTITY	A possible linkage between AMP-activated_protein_kinase -LRB- AMPK -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling pathway .
16953221	0	mTOR	48,52	AMPK	14,18	mTOR	AMPK	21977(Tax:10090)	5562	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|advcl|signalling	Dysfunctional AMPK activity , signalling through mTOR and survival in response to energetic stress in LKB1-deficient_lung_cancer .
19225536	0	mTOR	50,54	AMPK	73,77	mTOR	AMPK	21977(Tax:10090)	5563	Gene	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle_cell_lymphoma .
20811725	0	mTOR	129,133	AMPK	123,127	mTOR	AMPK	21977(Tax:10090)	5562	Gene	Gene	pathways|dep|START_ENTITY pathways|nsubj|kinase kinase|appos|END_ENTITY	2-Arylthiazolidine-4-carboxylic_acid_amides -LRB- ATCAA -RRB- target dual pathways in cancer cells : 5 ' - AMP-activated protein kinase -LRB- AMPK -RRB- / mTOR and PI3K/Akt/mTOR pathways .
24474794	0	mTOR	23,27	AMPK	57,61	mTOR	AMPK	21977(Tax:10090)	5563	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK .
24474794	0	mTOR	23,27	AMPK	86,90	mTOR	AMPK	21977(Tax:10090)	5563	Gene	Gene	regulation|compound|START_ENTITY mechanisms|nmod|regulation agonists|nsubj|mechanisms agonists|dobj|independent independent|nmod|END_ENTITY	Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK .
27035650	0	mTOR	15,19	AMPK	38,42	mTOR	AMPK	21977(Tax:10090)	5563	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of mTOR and regulation by AMPK in early iodine deficiency-induced thyroid microvascular activation .
21135252	0	mTOR	91,95	AP-1	0,4	mTOR	AP-1	21977(Tax:10090)	3725	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	AP-1 regulates cyclin_D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition : role of AIP4/Itch-mediated JUNB degradation .
12773158	0	mTOR	145,149	Akt	99,102	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY connect|nmod|mammalian_target_of_rapamycin connect|dobj|pathway pathway|compound|END_ENTITY	United at last : the tuberous_sclerosis complex gene products connect the phosphoinositide_3-kinase / Akt pathway to mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling .
15585641	0	mTOR	14,18	Akt	93,96	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	activity|compound|START_ENTITY Inhibition|nmod|activity restores|nsubj|Inhibition restores|nmod|Activity Activity|compound|END_ENTITY	Inhibition of mTOR activity restores tamoxifen response in breast_cancer cells with aberrant Akt Activity .
16452206	0	mTOR	0,4	Akt	82,85	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	inhibition|compound|START_ENTITY induces|nsubj|inhibition induces|xcomp|signaling signaling|dobj|END_ENTITY	mTOR inhibition induces upstream receptor_tyrosine_kinase signaling and activates Akt .
17121917	0	mTOR	46,50	Akt	75,78	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY mammalian_target_of_rapamycin|dep|inhibition inhibition|nmod|signaling signaling|compound|END_ENTITY	Statins induce mammalian_target_of_rapamycin -LRB- mTOR -RRB- - mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs .
17878402	0	mTOR	31,35	Akt	88,91	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	inhibition|appos|START_ENTITY activates|nsubj|inhibition activates|dobj|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition activates phosphatidylinositol_3-kinase / Akt by up-regulating insulin-like_growth_factor-1 receptor signaling in acute_myeloid_leukemia : rationale for therapeutic inhibition of both pathways .
18377870	0	mTOR	94,98	Akt	0,3	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	stimulation|nmod|START_ENTITY protects|nmod|stimulation protects|nsubj|activation activation|compound|END_ENTITY	Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR .
18794129	0	mTOR	41,45	Akt	143,146	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY mammalian_target_of_rapamycin|dep|therapy therapy|acl|preventing preventing|dobj|activation activation|compound|END_ENTITY	Enhancing mammalian_target_of_rapamycin -LRB- mTOR -RRB- - targeted cancer therapy by preventing mTOR/raptor inhibition-initiated , mTOR/rictor-independent Akt activation .
19176518	0	mTOR	16,20	Akt	54,57	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	START_ENTITY|nmod|PKC PKC|nmod|END_ENTITY	EGFR signals to mTOR through PKC and independently of Akt in glioma .
19530170	0	mTOR	80,84	Akt	20,23	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	branching|nmod|START_ENTITY promotes|dobj|branching promotes|nsubj|END_ENTITY	Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1 , respectively .
20356670	0	mTOR	46,50	Akt	27,30	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	inhibitors|compound|START_ENTITY response|nmod|inhibitors END_ENTITY|nmod|response	Compensatory activation of Akt in response to mTOR and Raf inhibitors - a rationale for dual-targeted therapy approaches in neuroendocrine_tumor_disease .
22338016	0	mTOR	47,51	Akt	0,3	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	resistance|compound|START_ENTITY overcome|dobj|resistance inhibitors|ccomp|overcome inhibitors|nsubj|END_ENTITY	Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse_large_B-cell_lymphoma .
22657251	0	mTOR	75,79	Akt	0,3	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	downstream|nmod|START_ENTITY isoform|dobj|downstream isoform|nsubj|END_ENTITY	Akt -LRB- protein_kinase_B -RRB- isoform phosphorylation and signaling downstream of mTOR -LRB- mammalian_target_of_rapamycin -RRB- in denervated atrophic and hypertrophic mouse skeletal muscle .
22684558	0	mTOR	55,59	Akt	137,140	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	shRNA|compound|START_ENTITY effect|nmod|shRNA improves|dobj|effect improves|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Suppression of EphB4 improves the inhibitory effect of mTOR shRNA on the biological behaviors of ovarian_cancer cells by down-regulating Akt phosphorylation .
23673367	0	mTOR	0,4	Akt	24,27	mTOR	Akt	21977(Tax:10090)	207	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	mTOR complex 2 mediates Akt phosphorylation that requires PKC _ in adult cardiac muscle cells .
23942361	0	mTOR	89,93	Akt	0,3	mTOR	Akt	21977(Tax:10090)	24185(Tax:10116)	Gene	Gene	activities|compound|START_ENTITY regulating|dobj|activities protect|advcl|regulating protect|nsubj|isoforms isoforms|compound|END_ENTITY	Akt isoforms differentially protect against stroke-induced neuronal_injury by regulating mTOR activities .
25534823	0	mTOR	21,25	Akt	0,3	mTOR	Akt	21977(Tax:10090)	11651(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Akt - or MEK-mediated mTOR inhibition suppresses Nf1 optic_glioma growth .
21720156	0	mTOR	29,33	Angiotensin_II	0,14	mTOR	Angiotensin II	21977(Tax:10090)	24179(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Angiotensin_II activation of mTOR results in tubulointerstitial fibrosis through loss of N-cadherin .
26124292	0	mTOR	20,24	Aurora_A	39,47	mTOR	Aurora A	21977(Tax:10090)	6790	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Mio depletion links mTOR regulation to Aurora_A and Plk1 activation at mitotic centrosomes .
11593425	0	mTOR	58,62	BCL-2	36,41	mTOR	BCL-2	21977(Tax:10090)	596	Gene	Gene	kinase|compound|START_ENTITY means|nmod|kinase inactivate|nmod|means inactivate|dobj|END_ENTITY	Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase .
24163374	0	mTOR	0,4	BCL-2	90,95	mTOR	BCL-2	21977(Tax:10090)	12043(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY sensitizes|nsubj|inhibition sensitizes|nmod|BCL-XL BCL-XL|compound|END_ENTITY	mTOR inhibition specifically sensitizes colorectal_cancers with KRAS or BRAF mutations to BCL-2 / BCL-XL inhibition by suppressing MCL-1 .
24396420	0	mTOR	67,71	BD1047	11,17	mTOR	BD1047	21977(Tax:10090)	2734415(Tax:264462)	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of BD1047 , a 1 receptor antagonist , on the expression of mTOR , Camk2y and GSK-3b in fluvoxamine-treated N2a cells .
19547753	0	mTOR	15,19	BDNF	0,4	mTOR	BDNF	21977(Tax:10090)	627	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	BDNF activates mTOR to regulate GluR1 expression required for memory formation .
25657994	0	mTOR	80,84	BRCA1-Associated_ATM_Activator-1	22,54	mTOR	BRCA1-Associated ATM Activator-1	21977(Tax:10090)	231841(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Role|nmod|Regulation Role|nmod|END_ENTITY	The Potential Role of BRCA1-Associated_ATM_Activator-1 -LRB- BRAT1 -RRB- in Regulation of mTOR .
15782132	0	mTOR	148,152	Bax	66,69	mTOR	Bax	21977(Tax:10090)	581	Gene	Gene	activity|compound|START_ENTITY mechanisms|nmod|activity increasing|nmod|mechanisms increasing|dobj|ratio ratio|compound|END_ENTITY	Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity .
23108993	0	mTOR	74,78	Bax	80,83	mTOR	Bax	21977(Tax:10090)	100355675(Tax:9986)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
15208671	0	mTOR	78,82	Bcl-2	0,5	mTOR	Bcl-2	21977(Tax:10090)	596	Gene	Gene	require|dobj|START_ENTITY require|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt .
15505422	0	mTOR	71,75	Bcl-2	0,5	mTOR	Bcl-2	21977(Tax:10090)	596	Gene	Gene	inhibitors|compound|START_ENTITY effects|nmod|inhibitors predict|dobj|effects predict|nsubj|levels levels|compound|END_ENTITY	Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian_carcinoma .
23108993	0	mTOR	74,78	Bcl-2	85,90	mTOR	Bcl-2	21977(Tax:10090)	100009447(Tax:9986)	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of ischemia post-conditioning on skeletal muscle oxidative injury , mTOR , Bax , Bcl-2 proteins expression , and HIF-1a / b-actin mRNA , IL-6 / b-actin mRNA and caveolin-3 / b-actin mRNA expression in ischemia-reperfusion rabbits .
25484022	0	mTOR	88,92	Bcl-2	70,75	mTOR	Bcl-2	21977(Tax:10090)	596	Gene	Gene	activation|compound|START_ENTITY mediated|nmod|activation END_ENTITY|acl|mediated	Lactate promotes resistance to glucose_starvation via upregulation of Bcl-2 mediated by mTOR activation .
26974552	0	mTOR	62,66	Bcl-2	183,188	mTOR	Bcl-2	21977(Tax:10090)	596	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|nmod|Down-Regulation Down-Regulation|nmod|END_ENTITY	Correction : Curcumin Significantly Enhances Dual PI3K/Akt and mTOR Inhibitor NVP-BEZ235-Induced Apoptosis in Human Renal_Carcinoma Caki Cells through Down-Regulation of p53-Dependent Bcl-2 Expression and Inhibition of Mcl-1 Protein Stability .
25896938	0	mTOR	37,41	Beclin-1	14,22	mTOR	Beclin-1	21977(Tax:10090)	8678	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation on Beclin-1 expression by mTOR in CoCl2-induced HT22 cell ischemia-reperfusion injury .
19738050	0	mTOR	0,4	CD133	58,63	mTOR	CD133	21977(Tax:10090)	8842	Gene	Gene	START_ENTITY|dobj|expression expression|compound|END_ENTITY	mTOR signal and hypoxia-inducible_factor-1_alpha regulate CD133 expression in cancer cells .
18270248	0	mTOR	150,154	CD25	42,46	mTOR	CD25	21977(Tax:10090)	3559	Gene	Gene	blockade|nmod|START_ENTITY accompanied|nmod|blockade administration|acl|accompanied +|nmod|administration +|nsubj|induction induction|nmod|Foxp3 Foxp3|compound|END_ENTITY	De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR .
16886599	0	mTOR	22,26	CD34	30,34	mTOR	CD34	21977(Tax:10090)	12490(Tax:10090)	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Activation of Akt and mTOR in CD34 + / K15 + keratinocyte stem cells and skin_tumors during multi-stage mouse skin_carcinogenesis .
18270248	0	mTOR	150,154	CD4	38,41	mTOR	CD4	21977(Tax:10090)	920	Gene	Gene	blockade|nmod|START_ENTITY accompanied|nmod|blockade administration|acl|accompanied +|nmod|administration +|nsubj|induction induction|nmod|Foxp3 Foxp3|compound|END_ENTITY	De novo induction of antigen-specific CD4 + CD25 + Foxp3 + regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR .
20335217	0	mTOR	0,4	CD4	25,28	mTOR	CD4	21977(Tax:10090)	920	Gene	Gene	shape|nsubj|START_ENTITY shape|dobj|stimulatory stimulatory|compound|END_ENTITY	mTOR and GSK-3 shape the CD4 + T-cell stimulatory and differentiation capacity of myeloid DCs after exposure to LPS .
22075384	0	mTOR	13,17	CD4	58,61	mTOR	CD4	21977(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis .
22545118	0	mTOR	121,125	CD4	37,40	mTOR	CD4	21977(Tax:10090)	920	Gene	Gene	inhibition|compound|START_ENTITY abrogated|nmod|inhibition abrogated|nsubjpass|reprogramming reprogramming|nmod|Foxp3 Foxp3|compound|END_ENTITY	Inflammation-driven reprogramming of CD4 + Foxp3 + regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo .
22904304	0	mTOR	15,19	CD4	102,105	mTOR	CD4	21977(Tax:10090)	920	Gene	Gene	activation|compound|START_ENTITY defines|nsubj|activation defines|dobj|signature signature|acl|controlling controlling|dobj|responses responses|nummod|+ +|compound|END_ENTITY	Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4 + effector T cell responses .
25500904	0	mTOR	73,77	CD4	24,27	mTOR	CD4	21977(Tax:10090)	920	Gene	Gene	activity|compound|START_ENTITY modulation|nmod|activity activation|nmod|modulation T-cell|acl|activation T-cell|compound|END_ENTITY	Azithromycin suppresses CD4 -LRB- + -RRB- T-cell activation by direct modulation of mTOR activity .
26371948	0	mTOR	0,4	Connective_Tissue_Growth_Factor	69,100	mTOR	Connective Tissue Growth Factor	21977(Tax:10090)	1490	Gene	Gene	START_ENTITY|dobj|Expression Expression|nmod|END_ENTITY	mTOR Complexes Repress Hypertrophic Agonist-Stimulated Expression of Connective_Tissue_Growth_Factor in Adult Cardiac Muscle Cells .
20818178	0	mTOR	38,42	DAP1	24,28	mTOR	DAP1	21977(Tax:10090)	1611	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	Autophagy gets a brake : DAP1 , a novel mTOR substrate , is activated to suppress the autophagic process .
19446321	0	mTOR	13,17	DEPTOR	0,6	mTOR	DEPTOR	21977(Tax:10090)	64798	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nsubj|END_ENTITY	DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival .
22017876	0	mTOR	11,15	DEPTOR	0,6	mTOR	DEPTOR	21977(Tax:10090)	64798	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	DEPTOR , an mTOR inhibitor , is a physiological substrate of SCF -LRB- bTrCP -RRB- E3 ubiquitin ligase and regulates survival and autophagy .
26558456	0	mTOR	79,83	DEPTOR	71,77	mTOR	DEPTOR	21977(Tax:10090)	64798	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Androgen_receptor functions as a negative transcriptional regulator of DEPTOR , mTOR inhibitor .
26825372	0	mTOR	107,111	DNA_damage-inducible_transcript_4	0,33	mTOR	DNA damage-inducible transcript 4	21977(Tax:10090)	140942(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	DNA_damage-inducible_transcript_4 -LRB- DDIT4 -RRB- mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes .
22265866	0	mTOR	186,190	ERK	146,149	mTOR	ERK	21977(Tax:10090)	5594	Gene	Gene	extracellular_signal-regulated_kinase|appos|START_ENTITY extracellular_signal-regulated_kinase|appos|END_ENTITY	The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular_signal-regulated_kinase -LRB- ERK -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathways in the dorsal hippocampus .
21898543	0	mTOR	55,59	Erythropoietin	0,14	mTOR	Erythropoietin	21977(Tax:10090)	13856(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY mediated|ccomp|regulated mediated|nsubj|END_ENTITY	Erythropoietin mediated bone formation is regulated by mTOR signaling .
22023617	0	mTOR	43,47	Erythropoietin	0,14	mTOR	Erythropoietin	21977(Tax:10090)	2056	Gene	Gene	pathways|nmod|START_ENTITY govern|dobj|pathways govern|nsubj|END_ENTITY	Erythropoietin and Wnt1 govern pathways of mTOR , Apaf-1 , and XIAP in inflammatory microglia .
23538752	0	mTOR	0,4	FANCD2	58,64	mTOR	FANCD2	21977(Tax:10090)	2177	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|pathway pathway|compound|END_ENTITY	mTOR regulates DNA damage response through NF-kB-mediated FANCD2 pathway in hematopoietic cells .
23633493	0	mTOR	28,32	FANCD2	14,20	mTOR	FANCD2	21977(Tax:10090)	2177	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks .
23852546	0	mTOR	0,4	FANCD2	115,121	mTOR	FANCD2	21977(Tax:10090)	2177	Gene	Gene	inhibitor|compound|START_ENTITY sensitizes|nsubj|inhibitor sensitizes|dobj|T-cell_lymphoblastic_leukemia T-cell_lymphoblastic_leukemia|nmod|damage damage|nmod|expression expression|compound|END_ENTITY	mTOR kinase inhibitor sensitizes T-cell_lymphoblastic_leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression .
18787170	0	mTOR	14,18	FBXW7	0,5	mTOR	FBXW7	21977(Tax:10090)	55294	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression .
21304100	0	mTOR	105,109	GATA-1	123,129	mTOR	GATA-1	21977(Tax:10090)	2623	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes .
26037201	0	mTOR	11,15	GLP-1	26,31	mTOR	GLP-1	21977(Tax:10090)	14526(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Intestinal mTOR regulates GLP-1 production in mouse L cells .
25385184	0	mTOR	50,54	GLUT1	74,79	mTOR	GLUT1	21977(Tax:10090)	6513	Gene	Gene	translocation|compound|START_ENTITY translocation|compound|END_ENTITY	Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation .
24587347	0	mTOR	91,95	GRP78	114,119	mTOR	GRP78	21977(Tax:10090)	3309	Gene	Gene	induction|compound|START_ENTITY induction|compound|END_ENTITY	JNK contributes to the tumorigenic potential of human cholangiocarcinoma cells through the mTOR pathway regulated GRP78 induction .
23877278	0	mTOR	84,88	Ghrelin	0,7	mTOR	Ghrelin	21977(Tax:10090)	58991(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY attenuates|advcl|activating attenuates|nsubj|END_ENTITY	Ghrelin attenuates intestinal_ischemia / reperfusion injury in mice by activating the mTOR signaling pathway .
26279396	0	mTOR	43,47	Ghrelin	0,7	mTOR	Ghrelin	21977(Tax:10090)	58991(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Ghrelin regulates GLP-1 production through mTOR signaling in L cells .
25349289	0	mTOR	16,20	HIF1a	0,5	mTOR	HIF1a	21977(Tax:10090)	15251(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	HIF1a Regulates mTOR Signaling and Viability of Prostate_Cancer Stem Cells .
22848663	0	mTOR	40,44	IKKb	63,67	mTOR	IKKb	21977(Tax:10090)	3551	Gene	Gene	START_ENTITY|xcomp|signaling signaling|nmod|END_ENTITY	Hepatitis_B_virus X protein upregulates mTOR signaling through IKKb to increase cell proliferation and VEGF production in hepatocellular_carcinoma .
24973821	0	mTOR	32,36	IL-15	54,59	mTOR	IL-15	21977(Tax:10090)	3600	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells .
11948686	0	mTOR	8,12	IRS-1	35,40	mTOR	IRS-1	21977(Tax:10090)	3667	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	Role of mTOR in the degradation of IRS-1 : regulation of PP2A activity .
16099428	0	mTOR	9,13	IRS-1	83,88	mTOR	IRS-1	21977(Tax:10090)	3667	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|END_ENTITY	Roles of mTOR and JNK in serine phosphorylation , translocation , and degradation of IRS-1 .
16530700	0	mTOR	37,41	IRS-1	0,5	mTOR	IRS-1	21977(Tax:10090)	3667	Gene	Gene	inhibitors|compound|START_ENTITY effectiveness|nmod|inhibitors auditing|dep|effectiveness END_ENTITY|dep|auditing	IRS-1 : auditing the effectiveness of mTOR inhibitors .
17721885	0	mTOR	85,89	IRS-1	93,98	mTOR	IRS-1	21977(Tax:10090)	3667	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells .
19561084	0	mTOR	159,163	IRS-1	135,140	mTOR	IRS-1	21977(Tax:10090)	3667	Gene	Gene	639|nmod|START_ENTITY regulates|nmod|639 regulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Raptor binds the SAIN -LRB- Shc and IRS-1 NPXY binding -RRB- domain of insulin_receptor_substrate-1 -LRB- IRS-1 -RRB- and regulates the phosphorylation of IRS-1 at Ser-636 / 639 by mTOR .
25531318	0	mTOR	39,43	LARP1	0,5	mTOR	LARP1	21977(Tax:10090)	23367	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression .
20717925	0	mTOR	58,62	Livin	26,31	mTOR	Livin	21977(Tax:10090)	79444	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|synthesis synthesis|amod|END_ENTITY	VEGF stimulation enhances Livin protein synthesis through mTOR signaling .
26280535	0	mTOR	0,4	MAPKAPK2	15,23	mTOR	MAPKAPK2	21977(Tax:10090)	9261	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|translation translation|compound|END_ENTITY	mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype .
26419804	0	mTOR	9,13	MAPKAPK2	24,32	mTOR	MAPKAPK2	21977(Tax:10090)	9261	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|translation translation|compound|END_ENTITY	Erratum : mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype .
21898400	0	mTOR	61,65	MMP9	32,36	mTOR	MMP9	21977(Tax:10090)	4318	Gene	Gene	targeting|dobj|START_ENTITY END_ENTITY|advcl|targeting	miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1 , and activate the Ras/Raf/MEK / Erk signaling pathway and NF-kB factor in human fibrosarcoma cells .
20419051	0	mTOR	103,107	Mammalian_Target_of_Rapamycin	72,101	mTOR	Mammalian Target of Rapamycin	21977(Tax:10090)	2475	Gene	Gene	Pathway|appos|START_ENTITY Pathway|compound|END_ENTITY	Developing Antiepileptogenic Drugs for Acquired Epilepsy : Targeting the Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Pathway .
23434669	0	mTOR	87,91	Mammalian_Target_of_Rapamycin	56,85	mTOR	Mammalian Target of Rapamycin	21977(Tax:10090)	2475	Gene	Gene	Pathway|appos|START_ENTITY Pathway|compound|END_ENTITY	Chemical Inhibitors and microRNAs -LRB- miRNA -RRB- Targeting the Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Pathway : Potential for Novel Anticancer Therapeutics .
26083478	0	mTOR	44,48	Mammalian_Target_of_Rapamycin	13,42	mTOR	Mammalian Target of Rapamycin	21977(Tax:10090)	2475	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery of Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Kinase Inhibitor CC-223 .
15621776	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in chronic lymphocytic_B-cell_leukemia : a new therapeutic option .
17878402	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition activates phosphatidylinositol_3-kinase / Akt by up-regulating insulin-like_growth_factor-1 receptor signaling in acute_myeloid_leukemia : rationale for therapeutic inhibition of both pathways .
19346248	0	mTOR	106,110	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|complex complex|compound|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity is associated with phosphorylation of raptor by mTOR .
20615870	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- activation increases axonal growth capacity of injured peripheral nerves .
22544534	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition : potential for antiseizure , antiepileptogenic , and epileptostatic therapy .
23573198	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- activity dependent phospho-protein expression in childhood acute_lymphoblastic_leukemia -LRB- ALL -RRB- .
23819792	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition does not prevent lung_adenocarcinoma-induced malignant_pleural_effusion .
24053120	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	non-infectious_pneumonitis|compound|START_ENTITY non-infectious_pneumonitis|compound|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor-associated non-infectious_pneumonitis in patients with renal_cell_cancer : predictors , management , and outcomes .
24371138	0	mTOR	31,35	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	56717(Tax:10090)	Gene	Gene	inhibition|appos|START_ENTITY inhibition|amod|END_ENTITY	Mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with rapamycin improves cardiac function in type 2 diabetic mice : potential role of attenuated oxidative stress and altered contractile protein expression .
26957088	0	mTOR	39,43	Mammalian_target_of_rapamycin	0,29	mTOR	Mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Mammalian_target_of_rapamycin complex -LRB- mTOR -RRB- pathway modulates blood-testis barrier -LRB- BTB -RRB- function through F-actin organization and gap junction .
26228571	0	mTOR	78,82	Mdm2	21,25	mTOR	Mdm2	21977(Tax:10090)	4193	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G_protein-coupled_receptor_kinase_2 in the regulation of GPR17 receptor desensitization .
26344767	0	mTOR	26,30	MeCP2	15,20	mTOR	MeCP2	21977(Tax:10090)	17257(Tax:10090)	Gene	Gene	Signaling|compound|START_ENTITY END_ENTITY|nmod|Signaling	miR-199a Links MeCP2 with mTOR Signaling and Its Dysregulation Leads to Rett Syndrome Phenotypes .
20501828	0	mTOR	22,26	MiR-199a-3p	0,11	mTOR	MiR-199a-3p	21977(Tax:10090)	406977	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells .
24509877	0	mTOR	44,48	NF1	62,65	mTOR	NF1	21977(Tax:10090)	4763	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 .
25534823	0	mTOR	21,25	Nf1	48,51	mTOR	Nf1	21977(Tax:10090)	18015(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY suppresses|nsubj|inhibition suppresses|dobj|growth growth|amod|END_ENTITY	Akt - or MEK-mediated mTOR inhibition suppresses Nf1 optic_glioma growth .
27050906	0	mTOR	0,4	Npm1	60,64	mTOR	Npm1	21977(Tax:10090)	4869	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation .
26546619	0	mTOR	0,4	PARP	76,80	mTOR	PARP	21977(Tax:10090)	1302	Gene	Gene	START_ENTITY|nmod|Inhibitors Inhibitors|compound|END_ENTITY	mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast_Cancer .
23183047	0	mTOR	19,23	PDK1	0,4	mTOR	PDK1	21977(Tax:10090)	5163	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	PDK1 regulation of mTOR and hypoxia-inducible_factor_1 integrate metabolism and migration of CD8 + T cells .
25418470	0	mTOR	131,135	PI-3K	125,130	mTOR	PI-3K	21977(Tax:10090)	5290	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Interleukin-1_beta induces the expression and production of stem_cell_factor by epithelial cells : crucial involvement of the PI-3K / mTOR pathway and HIF-1 transcription complex .
22388478	0	mTOR	96,100	PI_3-K	89,95	mTOR	PI 3-K	21977(Tax:10090)	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Prevention of b-amyloid degeneration of microglia by erythropoietin depends on Wnt1 , the PI_3-K / mTOR pathway , Bad , and Bcl-xL .
25792980	0	mTOR	83,87	PI_3_K	76,82	mTOR	PI 3 K	21977(Tax:10090)	5293	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Insulin Increases Sestrin_2 Content by Reducing Its Degradation through the PI_3_K / mTOR Signaling Pathway .
14653992	0	mTOR	15,19	PLD1	0,4	mTOR	PLD1	21977(Tax:10090)	5337	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1 .
12414639	0	mTOR	14,18	PTEN	63,67	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	resistance|compound|START_ENTITY Inhibitors|nmod|resistance conferred|nsubj|Inhibitors conferred|nmod|status status|compound|END_ENTITY	Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate_cancer cells .
18332865	0	mTOR	118,122	PTEN	15,19	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	inhibitors|compound|START_ENTITY conferring|nmod|inhibitors breast_cancer|advcl|conferring breast_cancer|nsubj|Suppression Suppression|nmod|increases increases|compound|END_ENTITY	Suppression of PTEN function increases breast_cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors .
18787170	0	mTOR	14,18	PTEN	55,59	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	targets|dobj|START_ENTITY targets|nmod|END_ENTITY	FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression .
18826385	0	mTOR	47,51	PTEN	34,38	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas .
19115995	0	mTOR	74,78	PTEN	0,4	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	regulating|dobj|START_ENTITY inhibiting|advcl|regulating END_ENTITY|acl|inhibiting	PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway .
20636791	0	mTOR	53,57	PTEN	29,33	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Immunohistochemical study of PTEN and phosphorylated mTOR proteins in familial and sporadic_invasive_breast_carcinomas .
21185267	0	mTOR	63,67	PTEN	0,4	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	activating|dobj|START_ENTITY prevents|advcl|activating prevents|nsubj|deletion deletion|compound|END_ENTITY	PTEN deletion prevents ischemic brain_injury by activating the mTOR signaling pathway .
22080063	0	mTOR	105,109	PTEN	5,9	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	pathway|compound|START_ENTITY involvement|nmod|pathway involvement|nmod|loss loss|compound|END_ENTITY	From PTEN loss of expression to RICTOR role in smooth muscle differentiation : complex involvement of the mTOR pathway in leiomyosarcomas and pleomorphic_sarcomas .
23205120	0	mTOR	34,38	PTEN	66,70	mTOR	PTEN	21977(Tax:10090)	5728	Gene	Gene	expression|nmod|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|compound|END_ENTITY	Immunohistochemical expression of mTOR negatively correlates with PTEN expression in gastric_carcinoma .
25266877	0	mTOR	10,14	PTEN	79,83	mTOR	PTEN	21977(Tax:10090)	19211(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY inhibitors|nsubj|Effect inhibitors|nmod|status status|amod|nude_mice nude_mice|nmod|END_ENTITY	Effect of mTOR inhibitors in nude_mice with endometrial_carcinoma and variable PTEN expression status .
18391955	0	mTOR	54,58	Phosphatidylinositol-3-OH_kinase	0,32	mTOR	Phosphatidylinositol-3-OH kinase	21977(Tax:10090)	5293	Gene	Gene	pathways|compound|START_ENTITY pathways|compound|END_ENTITY	Phosphatidylinositol-3-OH_kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking .
26023239	0	mTOR	91,95	Phosphatidylinositol_3-Kinase	22,51	mTOR	Phosphatidylinositol 3-Kinase	21977(Tax:10090)	5293	Gene	Gene	START_ENTITY|dep|Signaling Signaling|nmod|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
26023239	0	mTOR	91,95	Phosphatidylinositol_3-Kinase	22,51	mTOR	Phosphatidylinositol 3-Kinase	21977(Tax:10090)	5293	Gene	Gene	START_ENTITY|dep|Signaling Signaling|nmod|END_ENTITY	Signaling through the Phosphatidylinositol_3-Kinase -LRB- PI3K -RRB- / Mammalian_Target_of_Rapamycin -LRB- mTOR -RRB- Axis is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal_Growth_Factor_Receptor -LRB- EGFR -RRB- - mutated Lung_Adenocarcinoma .
11504907	0	mTOR	16,20	Pten	80,84	mTOR	Pten	21977(Tax:10090)	19211(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY reduces|nsubj|inhibitor reduces|dobj|activity activity|nmod|/ /|compound|END_ENTITY	An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten + / - mice .
17346540	0	mTOR	57,61	Pten	80,84	mTOR	Pten	21977(Tax:10090)	19211(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|model model|compound|END_ENTITY	Reduced progression of endometrial_hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model .
19185849	0	mTOR	0,4	Pten	77,81	mTOR	Pten	21977(Tax:10090)	19211(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|development development|nmod|prostate_cancer prostate_cancer|acl|induced induced|nmod|loss loss|amod|END_ENTITY	mTOR complex 2 is required for the development of prostate_cancer induced by Pten loss in mice .
21040901	0	mTOR	0,4	Pten	113,117	mTOR	Pten	21977(Tax:10090)	5728	Gene	Gene	activation|compound|START_ENTITY induces|nsubj|activation induces|dobj|suppressors suppressors|acl:relcl|inhibit inhibit|dobj|cells cells|nmod|deletion deletion|compound|END_ENTITY	mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion .
24322983	0	mTOR	120,124	Pten	82,86	mTOR	Pten	21977(Tax:10090)	19211(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY responsive|nmod|inhibition responsive|nsubj|model model|nmod|endometrial_cancer endometrial_cancer|acl|driven driven|nmod|loss loss|nmod|END_ENTITY	A genetic mouse model of invasive endometrial_cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition .
27050906	0	mTOR	0,4	Pten	135,139	mTOR	Pten	21977(Tax:10090)	5728	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|acl|contribute contribute|nmod|cells cells|nmod|inactivation inactivation|compound|END_ENTITY	mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation .
17706618	0	mTOR	53,57	RB1CC1	0,6	mTOR	RB1CC1	21977(Tax:10090)	12421(Tax:10090)	Gene	Gene	causes|nmod|START_ENTITY causes|nsubj|END_ENTITY	RB1CC1 insufficiency causes neuronal_atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer 's _ diseases .
15545625	0	mTOR	14,18	REDD1	54,59	mTOR	REDD1	21977(Tax:10090)	54541	Gene	Gene	Regulation|nmod|START_ENTITY function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 _ tumor suppressor complex .
22216185	0	mTOR	37,41	REN	56,59	mTOR	REN	21977(Tax:10090)	5972	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|cells cells|compound|END_ENTITY	Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1 .
22562250	0	mTOR	35,39	RGS4	27,31	mTOR	RGS4	21977(Tax:10090)	5999	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment .
25358403	0	mTOR	25,29	ROCK1	37,42	mTOR	ROCK1	21977(Tax:10090)	6093	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Clinical significance of mTOR , ZEB1 , ROCK1 expression in lung tissues of pulmonary_fibrosis patients .
21071439	0	mTOR	67,71	Raptor	21,27	mTOR	Raptor	21977(Tax:10090)	57521	Gene	Gene	activation|nmod|START_ENTITY promote|dobj|activation phosphorylate|xcomp|promote phosphorylate|dobj|END_ENTITY	ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 -LRB- mTORC1 -RRB- .
21900751	0	mTOR	41,45	Raptor	0,6	mTOR	Raptor	21977(Tax:10090)	57521	Gene	Gene	complex|compound|START_ENTITY subunit|nmod|complex END_ENTITY|appos|subunit	Raptor , a positive regulatory subunit of mTOR complex 1 , is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions -LRB- NORs -RRB- .
22493283	0	mTOR	56,60	Raptor	115,121	mTOR	Raptor	21977(Tax:10090)	57521	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY regulates|dobj|mammalian_target_of_rapamycin regulates|nmod|Kinase Kinase|dep|phosphorylation phosphorylation|compound|END_ENTITY	Osmotic stress regulates mammalian_target_of_rapamycin -LRB- mTOR -RRB- complex 1 via c-Jun N-terminal Kinase -LRB- JNK -RRB- - mediated Raptor protein phosphorylation .
24239769	0	mTOR	66,70	Raptor	11,17	mTOR	Raptor	21977(Tax:10090)	74370(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling phosphorylation|nmod|activation phosphorylation|nsubj|role role|nmod|END_ENTITY	A role for Raptor phosphorylation in the mechanical activation of mTOR signaling .
26582740	0	mTOR	62,66	Raptor	44,50	mTOR	Raptor	21977(Tax:10090)	31543(Tax:7227)	Gene	Gene	activation|amod|START_ENTITY determines|dobj|activation determines|nsubj|interaction interaction|nmod|END_ENTITY	Amino_acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation .
24768585	0	mTOR	35,39	Renin	0,5	mTOR	Renin	21977(Tax:10090)	5972	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Renin angiotensin system modulates mTOR pathway through AT2R in HIVAN .
12906785	0	mTOR	72,76	Rheb	143,147	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|acting acting|nmod|complex complex|nmod|END_ENTITY	Tuberous_sclerosis complex gene products , Tuberin and Hamartin , control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb .
14982927	0	mTOR	179,183	Rheb	142,146	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY mammalian_target_of_rapamycin|amod|hypoxia-inducible_factor-1 hypoxia-inducible_factor-1|nmod|homolog_enriched_in_brain homolog_enriched_in_brain|appos|END_ENTITY	Follicle-stimulating hormone activation of hypoxia-inducible_factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras _ homolog_enriched_in_brain -LRB- Rheb -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway is necessary for induction of select protein markers of follicular differentiation .
15854902	0	mTOR	29,33	Rheb	0,4	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	kinase|compound|START_ENTITY binds|dobj|kinase binds|nsubj|END_ENTITY	Rheb binds and regulates the mTOR kinase .
15878852	0	mTOR	47,51	Rheb	0,4	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	binding|appos|START_ENTITY binding|compound|END_ENTITY	Rheb binding to mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by amino_acid sufficiency .
16728407	0	mTOR	50,54	Rheb	102,106	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY Hyperactivation|nmod|mammalian_target_of_rapamycin Hyperactivation|acl|signaling signaling|nmod|mutant mutant|nmod|GTPase GTPase|compound|END_ENTITY	Hyperactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling by a gain-of-function mutant of the Rheb GTPase .
16757352	0	mTOR	19,23	Rheb	0,4	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	signaling|compound|START_ENTITY activation|nmod|signaling END_ENTITY|dobj|activation	Rheb activation of mTOR and S6K1 signaling .
17991864	0	mTOR	15,19	Rheb	0,4	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Rheb activates mTOR by antagonizing its endogenous inhibitor , FKBP38 .
18550814	0	mTOR	47,51	Rheb	35,39	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Phospholipase_D1 is an effector of Rheb in the mTOR pathway .
19451232	0	mTOR	27,31	Rheb	104,108	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate_dehydrogenase-mediated regulation of Rheb .
20837708	0	mTOR	20,24	Rheb	79,83	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	controls|dobj|START_ENTITY controls|nmod|regulation regulation|nmod|interaction interaction|nmod|END_ENTITY	Cyclic_AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase_4D .
21067284	0	mTOR	88,92	Rheb	153,157	mTOR	Rheb	21977(Tax:10090)	19744(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|acl|promoting promoting|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	Hydrogen_peroxide induces Beclin 1-independent autophagic cell death by suppressing the mTOR pathway via promoting the ubiquitination and degradation of Rheb in GSH-depleted RAW 264.7 cells .
24648513	0	mTOR	147,151	Rheb	61,65	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY regulator|nmod|mammalian_target_of_rapamycin generates|dobj|regulator generates|nsubj|mutation mutation|nmod|glycine glycine|nmod|END_ENTITY	Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
26782056	0	mTOR	38,42	Rheb	82,86	mTOR	Rheb	21977(Tax:10090)	6009	Gene	Gene	ketamine|nmod|START_ENTITY action|nmod|ketamine mediated|nsubjpass|action mediated|nmod|inhibition inhibition|nmod|degradation degradation|compound|END_ENTITY	Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation .
25043657	0	mTOR	0,4	RhoA	26,30	mTOR	RhoA	21977(Tax:10090)	387	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	mTOR regulate EMT through RhoA and Rac1 pathway in prostate_cancer .
20978191	0	mTOR	0,4	Rictor	23,29	mTOR	Rictor	21977(Tax:10090)	253260	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|amod|complex	mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis .
23239524	0	mTOR	0,4	SREBP-1	42,49	mTOR	SREBP-1	21977(Tax:10090)	78968(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	mTOR regulates fatty_infiltration through SREBP-1 and PPARy after a combined massive rotator cuff tear and suprascapular_nerve_injury in rats .
20847591	0	mTOR	36,40	SREBP1c	14,21	mTOR	SREBP1c	21977(Tax:10090)	6720	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of SREBP1c expression by mTOR signaling in hepatocytes .
23535559	0	mTOR	14,18	SYK	0,3	mTOR	SYK	21977(Tax:10090)	6850	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SYK regulates mTOR signaling in AML .
23599173	0	mTOR	105,109	Sex_determining_region_Y-box_2	0,30	mTOR	Sex determining region Y-box 2	21977(Tax:10090)	6657	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Sex_determining_region_Y-box_2 inhibits the proliferation of colorectal_adenocarcinoma cells through the mTOR signaling pathway .
24002653	0	mTOR	34,38	Smad3	0,5	mTOR	Smad3	21977(Tax:10090)	17127(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Smad3 induces atrogin-1 , inhibits mTOR and protein synthesis , and promotes muscle_atrophy in vivo .
18215134	0	mTOR	60,64	TBC1D1	14,20	mTOR	TBC1D1	21977(Tax:10090)	23216	Gene	Gene	pathway|compound|START_ENTITY regulates|nmod|pathway regulates|nsubj|END_ENTITY	Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes .
20543138	0	mTOR	0,4	TFIIIC	21,27	mTOR	TFIIIC	21977(Tax:10090)	2975	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	mTOR associates with TFIIIC , is found at tRNA and 5S rRNA genes , and targets their repressor Maf1 .
14729330	0	mTOR	29,33	TSC2	0,4	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	GAP|nmod|START_ENTITY filling|dobj|GAP END_ENTITY|parataxis|filling	TSC2 : filling the GAP in the mTOR signaling pathway .
16391386	0	mTOR	97,101	TSC2	36,40	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	pathway|compound|START_ENTITY regulation|nmod|pathway regulation|nmod|activity activity|nummod|END_ENTITY	Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway .
16816403	0	mTOR	58,62	TSC2	35,39	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	S6|compound|START_ENTITY END_ENTITY|nmod|S6	AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin_F2alpha .
17671177	0	mTOR	107,111	TSC2	23,27	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	activation|compound|START_ENTITY mediated|dobj|activation mediated|nsubj|Identification Identification|nmod|END_ENTITY	Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous_sclerosis and human cancer .
20145209	0	mTOR	64,68	TSC2	22,26	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	tumorigenesis|nmod|START_ENTITY tumorigenesis|nsubj|stabilization stabilization|nmod|suppresses suppresses|nummod|END_ENTITY	ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway .
20169078	0	mTOR	80,84	TSC2	64,68	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR .
21613414	0	mTOR	15,19	TSC2	46,50	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	GLUT1 enhances mTOR activity independently of TSC2 and AMPK .
22492229	0	mTOR	45,49	TSC2	130,134	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	role|appos|START_ENTITY role|nmod|down-regulation down-regulation|nmod|proteins proteins|appos|END_ENTITY	A role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in glutamate-induced down-regulation of tuberous_sclerosis complex proteins 2 -LRB- TSC2 -RRB- .
23265586	0	mTOR	164,168	TSC2	127,131	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	mammalian_target_of_rapamycin|dep|START_ENTITY expression|dep|mammalian_target_of_rapamycin expression|nmod|sclerosis_complex_subunit_2 sclerosis_complex_subunit_2|appos|END_ENTITY	Enhanced expression of glucose_transporter-1 in vascular smooth muscle cells via the Akt/tuberous _ sclerosis_complex_subunit_2 -LRB- TSC2 -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- / ribosomal S6 protein kinase -LRB- S6K -RRB- pathway in experimental renal_failure .
24398473	0	mTOR	39,43	TSC2	130,134	mTOR	TSC2	21977(Tax:10090)	7249	Gene	Gene	START_ENTITY|nmod|nitrosylation nitrosylation|nmod|END_ENTITY	Inducible nitric_oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2 .
21329734	0	mTOR	89,93	Visfatin	0,8	mTOR	Visfatin	21977(Tax:10090)	10135	Gene	Gene	exerts|nmod|START_ENTITY exerts|nsubj|END_ENTITY	Visfatin exerts angiogenic effects on human umbilical vein endothelial cells through the mTOR signaling pathway .
25358403	0	mTOR	25,29	ZEB1	31,35	mTOR	ZEB1	21977(Tax:10090)	6935	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Clinical significance of mTOR , ZEB1 , ROCK1 expression in lung tissues of pulmonary_fibrosis patients .
26122641	0	mTOR	0,4	c-fos	27,32	mTOR	c-fos	21977(Tax:10090)	2353	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines .
20126553	0	mTOR	71,75	eIF3f	35,40	mTOR	eIF3f	21977(Tax:10090)	66085(Tax:10090)	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse .
20064434	0	mTOR	30,34	eIF4E	103,108	mTOR	eIF4E	21977(Tax:10090)	1977	Gene	Gene	screen|nmod|START_ENTITY inhibitors|nsubj|screen inhibitors|advcl|accumulation accumulation|nmod|END_ENTITY	A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E .
21320304	0	mTOR	12,16	eIF4E	41,46	mTOR	eIF4E	21977(Tax:10090)	1977	Gene	Gene	inhibition|compound|START_ENTITY inhibition|dep|activity activity|nmod|END_ENTITY	Response to mTOR inhibition : activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast_cancer .
22216185	0	mTOR	37,41	eIF4E	101,106	mTOR	eIF4E	21977(Tax:10090)	1977	Gene	Gene	inhibition|compound|START_ENTITY translation|nmod|inhibition Sensitivity|nmod|translation depends|nsubj|Sensitivity depends|nmod|equilibrium equilibrium|nmod|END_ENTITY	Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1 .
24363449	0	mTOR	14,18	eIF4E	57,62	mTOR	eIF4E	21977(Tax:10090)	1977	Gene	Gene	kinase|compound|START_ENTITY Adaptation|nmod|kinase inhibitors|nsubj|Adaptation inhibitors|nmod|amplification amplification|nmod|END_ENTITY	Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation .
27050281	0	mTOR	86,90	eIF4E	129,134	mTOR	eIF4E	21977(Tax:10090)	1977	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	CGP57380 enhances efficacy of RAD001 in non-small_cell_lung_cancer through abrogating mTOR inhibition-induced phosphorylation of eIF4E and activating mitochondrial apoptotic pathway .
23029019	0	mTOR	61,65	erythropoietin	46,60	mTOR	erythropoietin	21977(Tax:10090)	2056	Gene	Gene	signaling|compound|START_ENTITY signaling|compound|END_ENTITY	PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cytoprotection .
23148990	0	mTOR	86,90	erythropoietin	22,36	mTOR	erythropoietin	21977(Tax:10090)	2056	Gene	Gene	kinase|compound|START_ENTITY activation|nmod|kinase linked|nmod|activation linked|nsubjpass|functions functions|nmod|END_ENTITY	Distinct functions of erythropoietin and stem_cell_factor are linked to activation of mTOR kinase signaling pathway in human erythroid progenitors .
14673156	0	mTOR	0,4	eukaryotic_translation_initiation_factor_4E	87,130	mTOR	eukaryotic translation initiation factor 4E	21977(Tax:10090)	1977	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	mTOR controls cell cycle progression through its cell growth effectors_S6K1_and_4E-BP1 / eukaryotic_translation_initiation_factor_4E .
23955309	0	mTOR	29,33	ghrelin	109,116	mTOR	ghrelin	21977(Tax:10090)	59301(Tax:10116)	Gene	Gene	intake|nmod|START_ENTITY Modulation|nmod|intake Modulation|dep|focus focus|nmod|END_ENTITY	Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats : focus on ghrelin and nesfatin-1 .
18460336	0	mTOR	21,25	hVps34	62,68	mTOR	hVps34	21977(Tax:10090)	5289	Gene	Gene	signaling|nsubj|START_ENTITY signaling|nmod|END_ENTITY	Amino_acids activate mTOR complex 1 via Ca2 + / CaM signaling to hVps34 .
20116405	0	mTOR	29,33	insulin-like_growth_factor-I_receptor	66,103	mTOR	insulin-like growth factor-I receptor	21977(Tax:10090)	3480	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like_growth_factor-I_receptor -LRB- IGF-IR -RRB- and human epidermal_growth_factor_receptor-2 -LRB- Her2 -RRB- expression in gastrointestinal_cancer cells .
17002884	0	mTOR	100,104	lysophosphatidic_acid_acyltransferase	32,69	mTOR	lysophosphatidic acid acyltransferase	21977(Tax:10090)	129642	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of a novel human lysophosphatidic_acid_acyltransferase , LPAAT-theta , which activates mTOR pathway .
11566616	0	mTOR	0,4	mTOR	65,69	mTOR	mTOR	21977(Tax:10090)	21977(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	mTOR , a novel target in breast_cancer : the effect of CCI-779 , an mTOR inhibitor , in preclinical models of breast_cancer .
11566616	0	mTOR	65,69	mTOR	0,4	mTOR	mTOR	21977(Tax:10090)	21977(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	mTOR , a novel target in breast_cancer : the effect of CCI-779 , an mTOR inhibitor , in preclinical models of breast_cancer .
12604610	0	mTOR	35,39	mTOR	68,72	mTOR	mTOR	21977(Tax:10090)	21977(Tax:10090)	Gene	Gene	partner|appos|START_ENTITY binds|nsubj|partner binds|ccomp|substrates substrates|nsubj|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
12604610	0	mTOR	68,72	mTOR	35,39	mTOR	mTOR	21977(Tax:10090)	21977(Tax:10090)	Gene	Gene	substrates|nsubj|START_ENTITY binds|ccomp|substrates binds|nsubj|partner partner|appos|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
24470663	0	mTOR	0,4	mTOR	59,63	mTOR	mTOR	21977(Tax:10090)	21977(Tax:10090)	Gene	Gene	START_ENTITY|dep|Inhibitor Inhibitor|compound|END_ENTITY	mTOR Signaling Cascade in Psoriatic Disease : Double Kinase mTOR Inhibitor a Novel Therapeutic Target .
24470663	0	mTOR	59,63	mTOR	0,4	mTOR	mTOR	21977(Tax:10090)	21977(Tax:10090)	Gene	Gene	Inhibitor|compound|START_ENTITY END_ENTITY|dep|Inhibitor	mTOR Signaling Cascade in Psoriatic Disease : Double Kinase mTOR Inhibitor a Novel Therapeutic Target .
21331075	0	mTOR	56,60	mTORC1	23,29	mTOR	mTORC1	21977(Tax:10090)	382056(Tax:10090)	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell_acute_lymphoblastic_leukemia .
25007995	0	mTOR	21,25	mTORC1	38,44	mTOR	mTORC1	21977(Tax:10090)	382056(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|activity activity|amod|END_ENTITY	Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress .
19285014	0	mTOR	74,78	mammalian_Target_Of_Rapamycin	43,72	mTOR	mammalian Target Of Rapamycin	21977(Tax:10090)	2475	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	The serine 2481-autophosphorylated form of mammalian_Target_Of_Rapamycin -LRB- mTOR -RRB- is localized to midzone and midbody in dividing cancer cells .
10947949	0	mTOR	205,209	mammalian_target_of_rapamycin	174,203	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	L-leucine availability regulates phosphatidylinositol_3-kinase , p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells : evidence for the involvement of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway in the L-leucine-induced up-regulation of system A amino_acid transport .
10972980	0	mTOR	90,94	mammalian_target_of_rapamycin	59,88	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	Assessment|appos|START_ENTITY Assessment|nmod|pathways pathways|nmod|regulation regulation|nmod|END_ENTITY	Assessment of cell-signaling pathways in the regulation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by amino_acids in rat adipocytes .
11942857	0	mTOR	136,140	mammalian_target_of_rapamycin	105,134	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	signalling|appos|START_ENTITY signalling|amod|END_ENTITY	Insulin regulation of hepatic_insulin-like_growth factor-binding protein-1 -LRB- IGFBP-1 -RRB- gene expression and mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling is impaired by the presence of hydrogen_peroxide .
12604610	0	mTOR	35,39	mammalian_target_of_rapamycin	4,33	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	partner|appos|START_ENTITY partner|compound|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
12604610	0	mTOR	68,72	mammalian_target_of_rapamycin	4,33	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	substrates|nsubj|START_ENTITY binds|ccomp|substrates binds|nsubj|partner partner|compound|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
14576155	0	mTOR	70,74	mammalian_target_of_rapamycin	39,68	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitors|appos|START_ENTITY END_ENTITY|dobj|inhibitors	AKT activity determines sensitivity to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors by regulating cyclin_D1 and c-myc expression .
14970221	0	mTOR	50,54	mammalian_target_of_rapamycin	19,48	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Thr2446 is a novel mammalian_target_of_rapamycin -LRB- mTOR -RRB- phosphorylation site regulated by nutrient status .
15459249	0	mTOR	67,71	mammalian_target_of_rapamycin	36,65	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Farnesylthiosalicylic_acid inhibits mammalian_target_of_rapamycin -LRB- mTOR -RRB- activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex .
15878852	0	mTOR	47,51	mammalian_target_of_rapamycin	16,45	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	binding|appos|START_ENTITY binding|nmod|END_ENTITY	Rheb binding to mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by amino_acid sufficiency .
15905173	0	mTOR	72,76	mammalian_target_of_rapamycin	41,70	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	Identification|appos|START_ENTITY Identification|nmod|S6_kinase_1 S6_kinase_1|nmod|END_ENTITY	Identification of S6_kinase_1 as a novel mammalian_target_of_rapamycin -LRB- mTOR -RRB- - phosphorylating kinase .
15923340	0	mTOR	181,185	mammalian_target_of_rapamycin	150,179	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	proliferation|appos|START_ENTITY proliferation|nmod|END_ENTITY	LY303511 -LRB- 2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one -RRB- acts via phosphatidylinositol_3-kinase-independent pathways to inhibit cell proliferation via mammalian_target_of_rapamycin -LRB- mTOR -RRB- - and non-mTOR-dependent mechanisms .
16344552	0	mTOR	72,76	mammalian_target_of_rapamycin	41,70	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Glucose-stimulated DNA synthesis through mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by KATP channels : effects on cell cycle progression in rodent islets .
16798736	0	mTOR	121,125	mammalian_target_of_rapamycin	14,43	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	stimulation|nmod|START_ENTITY associated|nmod|stimulation associated|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1 .
17041621	0	mTOR	73,77	mammalian_target_of_rapamycin	16,45	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	pass|nmod|START_ENTITY Upstream|parataxis|pass Upstream|nmod|END_ENTITY	Upstream of the mammalian_target_of_rapamycin : do all roads pass through mTOR ?
17234578	0	mTOR	177,181	mammalian_target_of_rapamycin	147,176	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The cationic amino_acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian_target_of_rapamycin mTOR pathway .
18326485	0	mTOR	80,84	mammalian_target_of_rapamycin	49,78	mTOR	mammalian target of rapamycin	21977(Tax:10090)	56717(Tax:10090)	Gene	Gene	mutant|compound|START_ENTITY mutant|compound|END_ENTITY	Cardiac restricted overexpression of kinase-dead mammalian_target_of_rapamycin -LRB- mTOR -RRB- mutant impairs the mTOR-mediated signaling and cardiac function .
18474609	0	mTOR	155,159	mammalian_target_of_rapamycin	124,153	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	fragile_X_mental_retardation_protein|appos|START_ENTITY fragile_X_mental_retardation_protein|nmod|END_ENTITY	S6K1 phosphorylates and regulates fragile_X_mental_retardation_protein -LRB- FMRP -RRB- with the neuronal protein synthesis-dependent mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling cascade .
18495876	0	mTOR	85,89	mammalian_target_of_rapamycin	54,83	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|tuberous_sclerosis tuberous_sclerosis|nmod|END_ENTITY	Response of a neuronal model of tuberous_sclerosis to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors : effects on mTORC1 and Akt signaling lead to improved survival and function .
19244117	0	mTOR	110,114	mammalian_target_of_rapamycin	33,62	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	marker|nmod|START_ENTITY marker|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	TORC-specific phosphorylation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- : phospho-Ser2481 is a marker for intact mTOR signaling complex 2 .
19473483	0	mTOR	95,99	mammalian_target_of_rapamycin	64,93	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	RAD001|compound|START_ENTITY RAD001|amod|END_ENTITY	Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor RAD001 strongly inhibits adhesion and growth of renal_cell_carcinoma cells .
19576515	0	mTOR	74,78	mammalian_target_of_rapamycin	43,72	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|nmod|END_ENTITY	Glutamate-dependent phosphorylation of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in Bergmann glial cells .
19875810	0	mTOR	47,51	mammalian_target_of_rapamycin	16,45	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in renal_disease .
19916508	0	mTOR	89,93	mammalian_target_of_rapamycin	58,87	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Morpholine derivatives greatly enhance the selectivity of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors .
19920197	0	mTOR	120,124	mammalian_target_of_rapamycin	20,49	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	axis|compound|START_ENTITY facilitating|nmod|axis signaling|advcl|facilitating END_ENTITY|acl|signaling	Perifosine inhibits mammalian_target_of_rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy .
20005385	0	mTOR	59,63	mammalian_target_of_rapamycin	28,57	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Immunosuppression using the mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor everolimus : pilot study shows significant cognitive and affective improvement .
20371977	0	mTOR	60,64	mammalian_target_of_rapamycin	29,58	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|autophagy autophagy|nmod|END_ENTITY	Involvement of autophagy via mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in tributyltin-induced neuronal cell death .
20421347	0	mTOR	75,79	mammalian_target_of_rapamycin	44,73	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	antagonists|appos|START_ENTITY antagonists|amod|END_ENTITY	Inhibition of human T-cell proliferation by mammalian_target_of_rapamycin -LRB- mTOR -RRB- antagonists requires noncoding RNA growth-arrest-specific_transcript_5 -LRB- GAS5 -RRB- .
20484410	0	mTOR	60,64	mammalian_target_of_rapamycin	29,58	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	cAMP-dependent activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- in thyroid cells .
20607654	0	mTOR	42,46	mammalian_target_of_rapamycin	11,40	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	A role for mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway in non alcoholic_steatohepatitis related-cirrhosis .
20797855	0	mTOR	104,108	mammalian_target_of_rapamycin	73,102	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
20860370	0	mTOR	187,191	mammalian_target_of_rapamycin	156,185	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Discovery of 1 - -LRB- 4 - -LRB- 4-propionylpiperazin-1-yl -RRB- -3 - -LRB- trifluoromethyl -RRB- phenyl -RRB- -9 - -LRB- quinolin-3-yl -RRB- benzo -LSB- h -RSB- -LSB- 1,6 -RSB- naphthyridin-2 -LRB- 1H -RRB- - one as a highly potent , selective mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor for the treatment of cancer .
21187044	0	mTOR	1,5	mammalian_target_of_rapamycin	11,40	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	-LSB- mTOR , the mammalian_target_of_rapamycin -RSB- .
21266573	0	mTOR	73,77	mammalian_target_of_rapamycin	42,71	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Naturally secreted amyloid-beta increases mammalian_target_of_rapamycin -LRB- mTOR -RRB- activity via a PRAS40-mediated mechanism .
21322566	0	mTOR	187,191	mammalian_target_of_rapamycin	156,185	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	Discovery of 9 - -LRB- 6-aminopyridin-3-yl -RRB- -1 - -LRB- 3 - -LRB- trifluoromethyl -RRB- phenyl -RRB- benzo -LSB- h -RSB- -LSB- 1,6 -RSB- naphthyridin-2 -LRB- 1H -RRB- - one -LRB- Torin2 -RRB- as a potent , selective , and orally available mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor for treatment of cancer .
21332118	0	mTOR	120,124	mammalian_target_of_rapamycin	89,118	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitors|appos|START_ENTITY END_ENTITY|dobj|inhibitors	Discovery and optimization of a series of benzothiazole phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors .
21354266	0	mTOR	51,55	mammalian_target_of_rapamycin	20,49	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Therapeutic role of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in preventing epileptogenesis .
21484496	0	mTOR	52,56	mammalian_target_of_rapamycin	21,50	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	directions|appos|START_ENTITY directions|nmod|END_ENTITY	Future directions of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor therapy in renal_cell_carcinoma .
21495671	0	mTOR	88,92	mammalian_target_of_rapamycin	57,86	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|nmod|END_ENTITY	Potent , selective , and orally bioavailable inhibitors of mammalian_target_of_rapamycin -LRB- mTOR -RRB- kinase based on a quaternary substituted dihydrofuropyrimidine .
21533544	0	mTOR	73,77	mammalian_target_of_rapamycin	42,71	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	biomarkers|appos|START_ENTITY biomarkers|nmod|activity activity|nmod|END_ENTITY	Predictive biomarkers for the activity of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors .
21735472	0	mTOR	89,93	mammalian_target_of_rapamycin	58,87	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	signal|appos|START_ENTITY signal|amod|END_ENTITY	Novel feedback inhibition of surface antigen synthesis by mammalian_target_of_rapamycin -LRB- mTOR -RRB- signal and its implication for hepatitis_B virus tumorigenesis and therapy .
21965657	0	mTOR	71,75	mammalian_target_of_rapamycin	10,39	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	complex|compound|START_ENTITY integrity|nmod|complex maintains|dobj|integrity maintains|nsubj|mTOR mTOR|appos|END_ENTITY	The mTOR -LRB- mammalian_target_of_rapamycin -RRB- kinase maintains integrity of mTOR complex 2 .
22040565	0	mTOR	47,51	mammalian_target_of_rapamycin	16,45	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	Inactivation|appos|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by rapamycin in a murine model of lipopolysaccharide-induced acute_lung_injury .
22223645	0	mTOR	84,88	mammalian_target_of_rapamycin	53,82	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Kinome-wide selectivity profiling of ATP-competitive mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors and characterization of their binding kinetics .
22337890	0	mTOR	167,171	mammalian_target_of_rapamycin	136,165	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Inhibition of chemokine -LRB- CXC motif -RRB- ligand 12/chemokine -LRB- CXC motif -RRB- receptor 4 axis -LRB- CXCL12/CXCR4 -RRB- - mediated cell migration by targeting mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway in human gastric_carcinoma cells .
22460837	0	mTOR	133,137	mammalian_target_of_rapamycin	102,131	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Comparative efficacy of vascular_endothelial_growth_factor -LRB- VEGF -RRB- tyrosine kinase inhibitor -LRB- TKI -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor as second-line therapy in patients with metastatic_renal_cell_carcinoma after the failure of first-line VEGF TKI .
22492229	0	mTOR	45,49	mammalian_target_of_rapamycin	14,43	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	A role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in glutamate-induced down-regulation of tuberous_sclerosis complex proteins 2 -LRB- TSC2 -RRB- .
22567115	0	mTOR	133,137	mammalian_target_of_rapamycin	102,131	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	The interaction between early life epilepsy and autistic-like behavioral consequences : a role for the mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway .
22645144	0	mTOR	118,122	mammalian_target_of_rapamycin	124,153	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic a2A receptor through the mTOR -LRB- mammalian_target_of_rapamycin -RRB- pathway : implication in new-onset diabetes in renal transplantation .
23054937	0	mTOR	43,47	mammalian_target_of_rapamycin	12,41	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in the treatment of advanced breast_cancer .
23185989	0	mTOR	17,21	mammalian_target_of_rapamycin	23,52	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	The mechanism of mTOR -LRB- mammalian_target_of_rapamycin -RRB- in a mouse model of polycystic_ovary_syndrome -LRB- PCOS -RRB- .
23587222	0	mTOR	45,49	mammalian_target_of_rapamycin	14,43	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- in triple_negative feline mammary_carcinomas .
23662044	0	mTOR	54,58	mammalian_target_of_rapamycin	23,52	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|END_ENTITY	Targeted inhibition of mammalian_target_of_rapamycin -LRB- mTOR -RRB- enhances radiosensitivity in pancreatic_carcinoma cells .
23838481	0	mTOR	47,51	mammalian_target_of_rapamycin	16,45	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Bone effects of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with everolimus .
23899586	0	mTOR	94,98	mammalian_target_of_rapamycin	63,92	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	suppression|appos|START_ENTITY suppression|amod|END_ENTITY	Alterations of hypoxia-induced factor signaling pathway due to mammalian_target_of_rapamycin -LRB- mTOR -RRB- suppression in ovarian_clear_cell_adenocarcinoma : in vivo and in vitro explorations for clinical trial .
24559928	0	mTOR	43,47	mammalian_target_of_rapamycin	12,41	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- complexes in pancreatic b-cell mass regulation .
24790108	0	mTOR	49,53	mammalian_target_of_rapamycin	18,47	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	complexes|appos|START_ENTITY complexes|amod|END_ENTITY	Mis-regulation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- complexes induced by albuminuria in proximal tubules .
25010764	0	mTOR	17,21	mammalian_target_of_rapamycin	23,52	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Significance of mTOR -LRB- mammalian_target_of_rapamycin -RRB- activity in human lymphomas -RSB- .
25769191	0	mTOR	66,70	mammalian_target_of_rapamycin	35,64	mTOR	mammalian target of rapamycin	21977(Tax:10090)	2475	Gene	Gene	Advances|appos|START_ENTITY Advances|nmod|use use|nmod|END_ENTITY	Advances in the therapeutic use of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors in dermatology .
26409044	0	mTOR	19,23	miR-100	0,7	mTOR	miR-100	21977(Tax:10090)	100314234(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|suppresses suppresses|amod|END_ENTITY	miR-100 suppresses mTOR signaling in hypoxia-induced pulmonary_hypertension in rats .
25055867	0	mTOR	51,55	miR-183	43,50	mTOR	miR-183	21977(Tax:10090)	387178(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	SMN regulates axonal local translation via miR-183 / mTOR pathway .
25348507	0	mTOR	29,33	miR-99a	0,7	mTOR	miR-99a	21977(Tax:10090)	407055	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	miR-99a directly targets the mTOR signalling pathway in breast_cancer side population cells .
25531317	0	mTOR	118,122	microRNA-96	84,95	mTOR	microRNA-96	21977(Tax:10090)	407053	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Transforming_growth_factor-b promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway .
20797855	0	mTOR	104,108	phosphatidylinositol-3-kinase	36,65	mTOR	phosphatidylinositol-3-kinase	21977(Tax:10090)	5293	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
15580312	0	mTOR	28,32	phospholipase_D	12,27	mTOR	phospholipase D	21977(Tax:10090)	2822	Gene	Gene	signal|compound|START_ENTITY signal|dep|END_ENTITY	Alternative phospholipase_D / mTOR survival signal in human breast_cancer cells .
16537399	0	mTOR	82,86	phospholipase_D	12,27	mTOR	phospholipase D	21977(Tax:10090)	2822	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	The role of phospholipase_D and phosphatidic_acid in the mechanical activation of mTOR signaling in skeletal muscle .
17102641	0	mTOR	14,18	polycystin-1	22,34	mTOR	polycystin-1	21977(Tax:10090)	5310	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of mTOR by polycystin-1 : is polycystic_kidney_disease a case of futile repair ?
12150925	0	mTOR	0,4	raptor	20,26	mTOR	raptor	21977(Tax:10090)	57521	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery .
12604610	0	mTOR	35,39	raptor	50,56	mTOR	raptor	21977(Tax:10090)	57521	Gene	Gene	partner|appos|START_ENTITY partner|appos|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
12604610	0	mTOR	68,72	raptor	50,56	mTOR	raptor	21977(Tax:10090)	57521	Gene	Gene	substrates|nsubj|START_ENTITY binds|ccomp|substrates binds|nsubj|partner partner|appos|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
15066126	0	mTOR	83,87	raptor	16,22	mTOR	raptor	21977(Tax:10090)	57521	Gene	Gene	function|compound|START_ENTITY inhibition|nmod|function mechanism|nmod|inhibition mechanism|nsubj|Dissociation Dissociation|nmod|END_ENTITY	Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function .
16824195	0	mTOR	144,148	raptor	114,120	mTOR	raptor	21977(Tax:10090)	57521	Gene	Gene	4E-BP1|nmod|START_ENTITY 4E-BP1|nmod|association association|nmod|END_ENTITY	Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size .
19346248	0	mTOR	106,110	raptor	96,102	mTOR	raptor	21977(Tax:10090)	57521	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity is associated with phosphorylation of raptor by mTOR .
23440873	0	mTOR	32,36	raptor	57,63	mTOR	raptor	21977(Tax:10090)	74370(Tax:10090)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and association of mTOR with its cofactors , raptor and rictor , in cumulus cells and oocytes during meiotic maturation in mice .
23454121	0	mTOR	33,37	thioredoxin_interacting_protein	63,94	mTOR	thioredoxin interacting protein	21977(Tax:10090)	10628	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Mechanistic target of rapamycin -LRB- mTOR -RRB- dependent regulation of thioredoxin_interacting_protein -LRB- TXNIP -RRB- transcription in hypoxia .
23102618	0	mTOR	0,4	tristetraprolin	49,64	mTOR	tristetraprolin	21977(Tax:10090)	7538	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	mTOR regulates cellular iron homeostasis through tristetraprolin .
23092880	0	mTORC1	0,6	Akt	53,56	mTORC1	Akt	382056(Tax:10090)	207	Gene	Gene	regulate|nsubj|START_ENTITY regulate|nmod|END_ENTITY	mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells .
24847056	0	mTORC1	60,66	CD4	106,109	mTORC1	CD4	382056(Tax:10090)	12504(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|cells cells|compound|END_ENTITY	Cytosolic branched chain aminotransferase -LRB- BCATc -RRB- regulates mTORC1 signaling and glycolytic metabolism in CD4 + T cells .
26471831	0	mTORC1	0,6	Chk1	70,74	mTORC1	Chk1	382056(Tax:10090)	1111	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|amod|END_ENTITY	mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition .
25898924	0	mTORC1	31,37	Collybistin	0,11	mTORC1	Collybistin	382056(Tax:10090)	23229	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Collybistin binds and inhibits mTORC1 signaling : a potential novel mechanism contributing to intellectual_disability and autism .
24969890	0	mTORC1	45,51	DEPTOR	0,6	mTORC1	DEPTOR	382056(Tax:10090)	64798	Gene	Gene	activity|amod|START_ENTITY correlates|nmod|activity correlates|nsubj|expression expression|amod|END_ENTITY	DEPTOR expression negatively correlates with mTORC1 activity and tumor progression in colorectal_cancer .
25936805	0	mTORC1	34,40	DEPTOR	52,58	mTORC1	DEPTOR	382056(Tax:10090)	64798	Gene	Gene	Inhibitor|amod|START_ENTITY Inhibitor|appos|END_ENTITY	Rapid Mitogenic Regulation of the mTORC1 Inhibitor , DEPTOR , by Phosphatidic_Acid .
20427710	0	mTORC1	41,47	ERK	60,63	mTORC1	ERK	382056(Tax:10090)	5594	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nmod|END_ENTITY	Phosphatidic_acid mediates activation of mTORC1 through the ERK signaling pathway .
22955917	0	mTORC1	79,85	ERK1/2	129,135	mTORC1	ERK1/2	382056(Tax:10090)	5595;5594	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Targeting NAD + salvage pathway induces autophagy in multiple_myeloma cells via mTORC1 and extracellular signal-regulated kinase -LRB- ERK1/2 -RRB- inhibition .
26522726	0	mTORC1	0,6	ERa	45,48	mTORC1	ERa	382056(Tax:10090)	2099	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	mTORC1 directly phosphorylates and activates ERa upon estrogen stimulation .
25082895	0	mTORC1	8,14	FGF21	91,96	mTORC1	FGF21	382056(Tax:10090)	26291	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	Hepatic mTORC1 controls locomotor activity , body temperature , and lipid metabolism through FGF21 .
24908670	0	mTORC1	75,81	Folliculin	0,10	mTORC1	Folliculin	382056(Tax:10090)	216805(Tax:10090)	Gene	Gene	deregulation|amod|START_ENTITY murine|nmod|deregulation leads|xcomp|murine leads|nsubj|inactivation inactivation|amod|END_ENTITY	Folliculin -LRB- Flcn -RRB- inactivation leads to murine cardiac_hypertrophy through mTORC1 deregulation .
27072130	0	mTORC1	38,44	Folliculin	17,27	mTORC1	Folliculin	382056(Tax:10090)	201163	Gene	Gene	Regulates|dobj|START_ENTITY Regulates|nsubj|END_ENTITY	Tumor Suppressor Folliculin Regulates mTORC1 through Primary Cilia .
26306048	0	mTORC1	18,24	Fyn	0,3	mTORC1	Fyn	382056(Tax:10090)	14360(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Fyn Activation of mTORC1 Stimulate the IRE1a-JNK Pathway Leading to Cell Death .
26975632	0	mTORC1	19,25	Gankyrin	0,8	mTORC1	Gankyrin	382056(Tax:10090)	5716	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal_cancer .
20972424	0	mTORC1	23,29	Lkb1	61,65	mTORC1	Lkb1	382056(Tax:10090)	20869(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Primary cilia regulate mTORC1 activity and cell size through Lkb1 .
20516213	0	mTORC1	0,6	MAF1	51,55	mTORC1	MAF1	382056(Tax:10090)	84232	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	mTORC1 directly phosphorylates and regulates human MAF1 .
21428925	0	mTORC1	22,28	MAF1	0,4	mTORC1	MAF1	382056(Tax:10090)	84232	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	MAF1 : a new target of mTORC1 .
26787466	0	mTORC1	45,51	MTMR3	24,29	mTORC1	MTMR3	382056(Tax:10090)	8897	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity .
19346248	0	mTORC1	41,47	Mammalian_target_of_rapamycin	0,29	mTORC1	Mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	associated|dep|START_ENTITY associated|nsubjpass|complex complex|compound|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity is associated with phosphorylation of raptor by mTOR .
22810227	0	mTORC1	41,47	Mammalian_target_of_rapamycin	0,29	mTORC1	Mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- and 2 -LRB- mTORC2 -RRB- control the dendritic arbor morphology of hippocampal neurons .
23278901	0	mTORC1	41,47	Mammalian_target_of_rapamycin	0,29	mTORC1	Mammalian target of rapamycin	382056(Tax:10090)	56717(Tax:10090)	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- may modulate the timing of anagen entry in mouse hair follicles .
23089982	0	mTORC1	31,37	PI3K	0,4	mTORC1	PI3K	382056(Tax:10090)	5293	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2 + breast_cancer cells .
17510057	0	mTORC1	17,23	PRAS40	0,6	mTORC1	PRAS40	382056(Tax:10090)	84335	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding .
26876939	0	mTORC1	0,6	PRAS40	72,78	mTORC1	PRAS40	382056(Tax:10090)	84335	Gene	Gene	Synthesis|amod|START_ENTITY Synthesis|nmod|END_ENTITY	mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress .
26597054	0	mTORC1	16,22	PRL-3	0,5	mTORC1	PRL-3	382056(Tax:10090)	19245(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	PRL-3 activates mTORC1 in Cancer Progression .
27039827	0	mTORC1	0,6	PTHrP	17,22	mTORC1	PTHrP	382056(Tax:10090)	19227(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	mTORC1 regulates PTHrP to coordinate chondrocyte growth , proliferation and differentiation .
20691905	0	mTORC1	60,66	Plzf	0,4	mTORC1	Plzf	382056(Tax:10090)	7704	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Plzf regulates germline progenitor self-renewal by opposing mTORC1 .
18070882	0	mTORC1	38,44	REDD1	56,61	mTORC1	REDD1	382056(Tax:10090)	54541	Gene	Gene	mTOR|appos|START_ENTITY turnover|nmod|mTOR repressor|nsubj|turnover repressor|dobj|END_ENTITY	Rapid turnover of the mTOR complex 1 -LRB- mTORC1 -RRB- repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis .
19297425	0	mTORC1	110,116	REDD1	128,133	mTORC1	REDD1	382056(Tax:10090)	140942(Tax:10116)	Gene	Gene	repressor|amod|START_ENTITY repressor|appos|END_ENTITY	Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor , REDD1 .
20100206	0	mTORC1	14,20	REDD1	33,38	mTORC1	REDD1	382056(Tax:10090)	54541	Gene	Gene	activity|amod|START_ENTITY activity|nmod|induction induction|nummod|END_ENTITY	Inhibition of mTORC1 activity by REDD1 induction in myeloma cells resistant to bortezomib cytotoxicity .
23717519	0	mTORC1	0,6	REDD1	31,36	mTORC1	REDD1	382056(Tax:10090)	54541	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|stability stability|compound|END_ENTITY	mTORC1 dependent regulation of REDD1 protein stability .
24018049	0	mTORC1	194,200	REDD1	43,48	mTORC1	REDD1	382056(Tax:10090)	54541	Gene	Gene	repression|appos|START_ENTITY sustaining|dobj|repression promotes|advcl|sustaining promotes|nsubj|1 1|appos|END_ENTITY	Regulated in DNA damage and development 1 -LRB- REDD1 -RRB- promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 -LRB- mTORC1 -RRB- .
24338366	0	mTORC1	72,78	REDD1	33,38	mTORC1	REDD1	382056(Tax:10090)	54541	Gene	Gene	activation|amod|START_ENTITY contributes|nmod|activation contributes|nsubj|translocation translocation|nmod|END_ENTITY	Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation .
24876363	0	mTORC1	29,35	REDD1	62,67	mTORC1	REDD1	382056(Tax:10090)	74747(Tax:10090)	Gene	Gene	START_ENTITY|nmod|result result|nmod|changes changes|nmod|expression expression|compound|END_ENTITY	Altered nutrient response of mTORC1 as a result of changes in REDD1 expression : effect of obesity vs. REDD1_deficiency .
25056877	0	mTORC1	83,89	REDD1	0,5	mTORC1	REDD1	382056(Tax:10090)	74747(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	REDD1 enhances protein phosphatase_2A-mediated dephosphorylation of Akt to repress mTORC1 signaling .
25159324	0	mTORC1	54,60	REDD1	8,13	mTORC1	REDD1	382056(Tax:10090)	74747(Tax:10090)	Gene	Gene	following|amod|START_ENTITY activation|nmod|following contributes|nmod|activation contributes|nsubj|expression expression|compound|END_ENTITY	Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction .
25539833	0	mTORC1	70,76	REDD1	27,32	mTORC1	REDD1	382056(Tax:10090)	140942(Tax:10116)	Gene	Gene	signaling|dep|START_ENTITY signaling|nsubj|expression expression|compound|END_ENTITY	Endurance exercise induces REDD1 expression and transiently decreases mTORC1 signaling in rat skeletal muscle .
26487002	0	mTORC1	64,70	REDD1	14,19	mTORC1	REDD1	382056(Tax:10090)	74747(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY ameliorates|nmod|signaling ameliorates|nsubj|Disruption Disruption|nmod|gene gene|compound|END_ENTITY	Disruption of REDD1 gene ameliorates sepsis-induced decrease in mTORC1 signaling but has divergent effects on proteolytic signaling in skeletal muscle .
25936802	0	mTORC1	65,71	RNF152	37,43	mTORC1	RNF152	382056(Tax:10090)	220441	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation .
26767763	0	mTORC1	25,31	RRAGC	0,5	mTORC1	RRAGC	382056(Tax:10090)	64121	Gene	Gene	Signaling|compound|START_ENTITY Signaling|compound|END_ENTITY	RRAGC Mutations Activate mTORC1 Signaling in Follicular_Lymphoma .
21659537	0	mTORC1	221,227	RSK	198,201	mTORC1	RSK	382056(Tax:10090)	6197	Gene	Gene	protein|amod|START_ENTITY control|nmod|protein p90|nmod|control p90|appos|END_ENTITY	Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular _ signal-regulated_kinase kinase -LRB- MEK -RRB- , extracellular_signal-regulated_kinase -LRB- ERK -RRB- , and p90 -LRB- RSK -RRB- in the control of mTORC1 protein signaling by phorbol_esters .
22797077	0	mTORC1	43,49	RSK	0,3	mTORC1	RSK	382056(Tax:10090)	6196	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth .
25889895	0	mTORC1	59,65	RSK	16,19	mTORC1	RSK	382056(Tax:10090)	6196	Gene	Gene	alter|dobj|START_ENTITY alter|nsubj|inhibitors inhibitors|compound|END_ENTITY	Two widely used RSK inhibitors , BI-D1870 and SL0101 , alter mTORC1 signaling in a RSK-independent manner .
23478338	0	mTORC1	16,22	Rab12	0,5	mTORC1	Rab12	382056(Tax:10090)	201475	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4 .
25446900	0	mTORC1	12,18	Rab1A	0,5	mTORC1	Rab1A	382056(Tax:10090)	5861	Gene	Gene	Activator|amod|START_ENTITY Activator|nsubj|END_ENTITY	Rab1A Is an mTORC1 Activator and a Colorectal Oncogene .
21474067	0	mTORC1	31,37	Rac1	0,4	mTORC1	Rac1	382056(Tax:10090)	5879	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size .
26234902	0	mTORC1	34,40	Rheb	0,4	mTORC1	Rheb	382056(Tax:10090)	6009	Gene	Gene	signaling|dep|START_ENTITY signaling|compound|END_ENTITY	Rheb signaling and tumorigenesis : mTORC1 and new horizons .
21238928	0	mTORC1	22,28	Rheb1	0,5	mTORC1	Rheb1	382056(Tax:10090)	19744(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Rheb1 is required for mTORC1 and myelination in postnatal brain development .
27071307	0	mTORC1	41,47	Rheb1	0,5	mTORC1	Rheb1	382056(Tax:10090)	19744(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute_myeloid_leukemia .
26390293	0	mTORC1	31,37	Sestrin2	13,21	mTORC1	Sestrin2	382056(Tax:10090)	83667	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Corrigendum : Sestrin2 inhibits mTORC1 through modulation of GATOR complexes .
26390293	0	mTORC1	31,37	Sestrin2	13,21	mTORC1	Sestrin2	382056(Tax:10090)	83667	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Corrigendum : Sestrin2 inhibits mTORC1 through modulation of GATOR complexes .
26449471	0	mTORC1	37,43	Sestrin2	0,8	mTORC1	Sestrin2	382056(Tax:10090)	83667	Gene	Gene	pathway|amod|START_ENTITY sensor|nmod|pathway sensor|nsubj|END_ENTITY	Sestrin2 is a leucine sensor for the mTORC1 pathway .
26543160	0	mTORC1	14,20	Sestrin2	73,81	mTORC1	Sestrin2	382056(Tax:10090)	83667	Gene	Gene	suppression|amod|START_ENTITY sustains|dobj|suppression sustains|advcl|inducing inducing|dobj|END_ENTITY	GCN2 sustains mTORC1 suppression upon amino_acid deprivation by inducing Sestrin2 .
27010498	0	mTORC1	55,61	Sestrin2	37,45	mTORC1	Sestrin2	382056(Tax:10090)	83667	Gene	Gene	activation|amod|START_ENTITY promotes|dobj|activation promotes|nsubj|dephosphorylation dephosphorylation|nmod|END_ENTITY	Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation .
21804531	0	mTORC1	36,42	TFEB	14,18	mTORC1	TFEB	382056(Tax:10090)	7942	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of TFEB and V-ATPases by mTORC1 .
22692423	0	mTORC1	36,42	TFEB	25,29	mTORC1	TFEB	382056(Tax:10090)	7942	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis .
22081070	0	mTORC1	35,41	TR3	21,24	mTORC1	TR3	382056(Tax:10090)	3164	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The nuclear receptor TR3 regulates mTORC1 signaling in lung_cancer cells expressing wild-type p53 .
20160076	0	mTORC1	49,55	TSC2	15,19	mTORC1	TSC2	382056(Tax:10090)	22084(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY cytoplasm|acl|regulate END_ENTITY|nmod|cytoplasm	ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS .
21886784	0	mTORC1	107,113	TSC2	12,16	mTORC1	TSC2	382056(Tax:10090)	22084(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY increasing|nmod|activation enhances|advcl|increasing enhances|nsubj|Ablation Ablation|nmod|END_ENTITY	Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 .
22607231	0	mTORC1	77,83	TSC2	97,101	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Natural product-derived antitumor compound phenethyl_isothiocyanate inhibits mTORC1 activity via TSC2 .
25724664	0	mTORC1	109,115	TSC2	38,42	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	Everolimus|amod|START_ENTITY Frequent|nmod|Everolimus Frequent|nsubjpass|Loss Loss|nmod|Tuberous_Sclerosis_Complex_2 Tuberous_Sclerosis_Complex_2|appos|END_ENTITY	Loss of Tuberous_Sclerosis_Complex_2 -LRB- TSC2 -RRB- Is Frequent in Hepatocellular_Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus .
25972538	0	mTORC1	70,76	TSC2	38,42	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	Activation|nmod|START_ENTITY Tuberous_Sclerosis_Complex_Protein_2|dep|Activation Tuberous_Sclerosis_Complex_Protein_2|appos|END_ENTITY	Tuberous_Sclerosis_Complex_Protein_2 -LRB- TSC2 -RRB- - Independent Activation of mTORC1 by Human_Cytomegalovirus pUL38 .
26345496	0	mTORC1	58,64	TSC2	0,4	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	inactivation|nmod|START_ENTITY mediates|dobj|inactivation mediates|nsubj|END_ENTITY	TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1 .
26345496	0	mTORC1	58,64	TSC2	0,4	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	inactivation|nmod|START_ENTITY mediates|dobj|inactivation mediates|nsubj|END_ENTITY	TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1 .
26374334	0	mTORC1	60,66	TSC2	47,51	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	Mediated|nmod|START_ENTITY Mediated|nmod|END_ENTITY	Differential IKK/NF-kB Activity Is Mediated by TSC2 through mTORC1 in PTEN-Null Prostate_Cancer and Tuberous_Sclerosis_Complex_Tumor Cells .
26385560	0	mTORC1	42,48	TSC2	92,96	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	Activity|amod|START_ENTITY Enhance|dobj|Activity Enhance|nmod|Dynamics Dynamics|nmod|END_ENTITY	p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb .
26975632	0	mTORC1	19,25	TSC2	52,56	mTORC1	TSC2	382056(Tax:10090)	7249	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|degradation degradation|compound|END_ENTITY	Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal_cancer .
21795849	0	mTORC1	37,43	ULK1	0,4	mTORC1	ULK1	382056(Tax:10090)	8408	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	ULK1 inhibits the kinase activity of mTORC1 and cell proliferation .
24497849	0	mTORC1	46,52	WNT7B	0,5	mTORC1	WNT7B	382056(Tax:10090)	22422(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	WNT7B promotes bone formation in part through mTORC1 .
18945681	0	mTORC1	76,82	hypoxia-inducible_factors_1_alpha_and_2_alpha	27,72	mTORC1	hypoxia-inducible factors 1 alpha and 2 alpha	382056(Tax:10090)	3091;2034	Gene	Gene	dependence|nmod|START_ENTITY dependence|nmod|END_ENTITY	Differential dependence of hypoxia-inducible_factors_1_alpha_and_2_alpha on mTORC1 and mTORC2 .
25738366	0	mTORC1	58,64	mSin1	19,24	mTORC1	mSin1	382056(Tax:10090)	227743(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 .
21331075	0	mTORC1	23,29	mTOR	56,60	mTORC1	mTOR	382056(Tax:10090)	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell_acute_lymphoblastic_leukemia .
25007995	0	mTORC1	38,44	mTOR	21,25	mTORC1	mTOR	382056(Tax:10090)	21977(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulate|dobj|activity END_ENTITY|xcomp|regulate	Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress .
21307309	0	mTORC1	81,87	mammalian_target_of_Rapamycin	40,69	mTORC1	mammalian target of Rapamycin	382056(Tax:10090)	2475	Gene	Gene	inhibition|appos|START_ENTITY inhibition|nmod|I I|amod|END_ENTITY	Selective pharmacogenetic inhibition of mammalian_target_of_Rapamycin complex I -LRB- mTORC1 -RRB- blocks long-term synaptic plasticity and memory storage .
18372248	0	mTORC1	113,119	mammalian_target_of_rapamycin	72,101	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	Regulation of proline-rich_Akt_substrate_of_40_kDa -LRB- PRAS40 -RRB- function by mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- - mediated phosphorylation .
18495876	0	mTORC1	114,120	mammalian_target_of_rapamycin	54,83	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	effects|nmod|START_ENTITY Response|dep|effects Response|nmod|model model|nmod|inhibitors inhibitors|amod|tuberous_sclerosis tuberous_sclerosis|nmod|END_ENTITY	Response of a neuronal model of tuberous_sclerosis to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors : effects on mTORC1 and Akt signaling lead to improved survival and function .
18949455	0	mTORC1	55,61	mammalian_target_of_rapamycin	14,43	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	signalling|compound|START_ENTITY signalling|amod|END_ENTITY	Early loss of mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha -LRB- HNF1A -RRB- function in INS-1 insulinoma cells .
19150980	0	mTORC1	100,106	mammalian_target_of_rapamycin	19,48	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	functions|nmod|START_ENTITY reveals|dobj|functions reveals|nsubj|inhibitor inhibitor|compound|END_ENTITY	An ATP-competitive mammalian_target_of_rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 .
21757713	0	mTORC1	111,117	mammalian_target_of_rapamycin	70,99	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activation .
21784859	0	mTORC1	57,63	mammalian_target_of_rapamycin	16,45	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Redox regulates mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity by modulating the TSC1/TSC2-Rheb GTPase pathway .
23317821	0	mTORC1	150,156	mammalian_target_of_rapamycin	109,138	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	effects|appos|START_ENTITY effects|nmod|END_ENTITY	Regulation of blood-testis barrier -LRB- BTB -RRB- dynamics during spermatogenesis via the `` Yin '' and `` Yang '' effects of mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- and mTORC2 .
24990947	0	mTORC1	28,34	mammalian_target_of_rapamycin	77,106	mTORC1	mammalian target of rapamycin	382056(Tax:10090)	2475	Gene	Gene	complex|amod|START_ENTITY activation|nmod|complex involves|nsubj|activation involves|dobj|phosphorylation phosphorylation|nmod|mTOR mTOR|appos|END_ENTITY	Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR -LRB- mammalian_target_of_rapamycin -RRB- by IkB_kinase_a -LRB- IKKa -RRB- .
21508335	0	mTORC1	0,6	neurotensin	28,39	mTORC1	neurotensin	382056(Tax:10090)	4922	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON .
22024166	0	mTORC1	73,79	phospholipase_D	32,47	mTORC1	phospholipase D	382056(Tax:10090)	2822	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Class III PI-3-kinase activates phospholipase_D in an amino_acid-sensing mTORC1 pathway .
22170591	0	mTORC1	58,64	vegf	41,45	mTORC1	vegf	382056(Tax:10090)	7422	Gene	Gene	pathway|nmod|START_ENTITY pathway|compound|END_ENTITY	Electroconvulsive seizures stimulate the vegf pathway via mTORC1 .
26130148	0	mTORC2	0,6	AKT	16,19	mTORC2	AKT	74343(Tax:10090)	207	Gene	Gene	Activation|amod|START_ENTITY Activation|compound|END_ENTITY	mTORC2 Balances AKT Activation and eIF2a Serine 51 Phosphorylation to Promote Survival under Stress .
17011481	0	mTORC2	0,6	Akt	26,29	mTORC2	Akt	74343(Tax:10090)	207	Gene	Gene	Caught|compound|START_ENTITY Caught|nmod|END_ENTITY	mTORC2 Caught in a SINful Akt .
19641186	0	mTORC2	143,149	Akt	121,124	mTORC2	Akt	74343(Tax:10090)	207	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse_large_B-cell_lymphoma by inhibiting Akt signaling through mTORC2 .
21045808	0	mTORC2	0,6	Akt	104,107	mTORC2	Akt	74343(Tax:10090)	207	Gene	Gene	associate|nsubj|START_ENTITY associate|xcomp|promote promote|dobj|phosphorylation phosphorylation|nmod|polypeptide polypeptide|compound|END_ENTITY	mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide .
21956113	0	mTORC2	146,152	Akt	103,106	mTORC2	Akt	74343(Tax:10090)	207	Gene	Gene	protein|amod|START_ENTITY phosphorylation|nmod|protein serine|dobj|phosphorylation dependent|ccomp|serine dependent|nmod|protein protein|compound|END_ENTITY	Mechanical regulation of glycogen_synthase_kinase_3b -LRB- GSK3b -RRB- in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein .
22084251	0	mTORC2	88,94	Akt	125,128	mTORC2	Akt	74343(Tax:10090)	207	Gene	Gene	mammalian_target_of_rapamycin|appos|START_ENTITY acetylation|nmod|mammalian_target_of_rapamycin acetylation|dep|phosphorylation phosphorylation|nmod|protein protein|compound|END_ENTITY	Multiple site acetylation of Rictor stimulates mammalian_target_of_rapamycin complex 2 -LRB- mTORC2 -RRB- - dependent phosphorylation of Akt protein .
22521878	0	mTORC2	8,14	Akt	60,63	mTORC2	Akt	74343(Tax:10090)	11651(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|nmod|END_ENTITY	Hepatic mTORC2 activates glycolysis and lipogenesis through Akt , glucokinase , and SREBP1c .
23684622	0	mTORC2	70,76	Akt	47,50	mTORC2	Akt	74343(Tax:10090)	207	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2 .
21592956	0	mTORC2	0,6	Akt1	102,106	mTORC2	Akt1	74343(Tax:10090)	207	Gene	Gene	Akt|amod|START_ENTITY Serine|nsubj|Akt Serine|ccomp|required required|nmod|activity activity|amod|END_ENTITY	mTORC2 protein complex-mediated Akt -LRB- Protein_Kinase_B -RRB- Serine 473 Phosphorylation is not required for Akt1 activity in human platelets -LSB- corrected -RSB- .
24949720	0	mTORC2	0,6	Akt1	26,30	mTORC2	Akt1	74343(Tax:10090)	24185(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	mTORC2 phosphorylation of Akt1 : a possible mechanism for hydrogen_sulfide-induced cardioprotection .
23000059	0	mTORC2	30,36	Estrogen_receptor	0,17	mTORC2	Estrogen receptor	74343(Tax:10090)	2099	Gene	Gene	potentiates|dobj|START_ENTITY potentiates|nsubj|END_ENTITY	Estrogen_receptor potentiates mTORC2 signaling in breast_cancer cells by upregulating superoxide anions .
24270265	0	mTORC2	41,47	Mammalian_target_of_rapamycin	0,29	mTORC2	Mammalian target of rapamycin	74343(Tax:10090)	2475	Gene	Gene	complex|appos|START_ENTITY complex|compound|END_ENTITY	Mammalian_target_of_rapamycin complex 2 -LRB- mTORC2 -RRB- coordinates pulmonary artery smooth muscle cell metabolism , proliferation , and survival in pulmonary_arterial_hypertension .
23836527	0	mTORC2	36,42	RhoA	55,59	mTORC2	RhoA	74343(Tax:10090)	387	Gene	Gene	START_ENTITY|xcomp|regulate regulate|dobj|END_ENTITY	Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells .
24516119	0	mTORC2	81,87	TNF	22,25	mTORC2	TNF	74343(Tax:10090)	7124	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|dobj|induction induction|compound|END_ENTITY	Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2 .
24043828	0	mTORC2	35,41	XPLN	0,4	mTORC2	XPLN	74343(Tax:10090)	50650	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	XPLN is an endogenous inhibitor of mTORC2 .
25594024	0	mTORC2	13,19	c-FLIP	0,6	mTORC2	c-FLIP	74343(Tax:10090)	8837	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	c-FLIP links mTORC2 to apoptosis .
24557881	0	mTORC2	16,22	ribosomal_protein_S6	42,62	mTORC2	ribosomal protein S6	74343(Tax:10090)	20104(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Pivotal role of mTORC2 and involvement of ribosomal_protein_S6 in cardioprotective signaling .
19018001	0	mTORC2	61,67	vascular_endothelial_growth_factor	101,135	mTORC2	vascular endothelial growth factor	74343(Tax:10090)	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	CD40-induced signaling in human endothelial cells results in mTORC2 - and Akt-dependent expression of vascular_endothelial_growth_factor in vitro and in vivo .
16306123	0	mTRPC5	73,79	calmodulin	15,25	mTRPC5	calmodulin	22067(Tax:10090)	808	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Involvement of calmodulin and myosin_light_chain_kinase in activation of mTRPC5 expressed in HEK cells .
8001976	0	mTRiC-P5	41,49	TRIC5	56,61	mTRiC-P5	TRIC5	12462(Tax:10090)	7203	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human homologue of the mTRiC-P5 gene -LRB- TRIC5 -RRB- to band 1q23 by fluorescence in situ hybridization .
24243494	0	mToR	69,73	PDGFR	34,39	mToR	PDGFR	21977(Tax:10090)	5159	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|nmod|END_ENTITY	Immunohistochemical expression of PDGFR , VEGF-C , and proteins of the mToR pathway before and after androgen_deprivation_therapy in prostate_carcinoma : significant decrease after treatment .
15342353	0	mUBPy	28,33	MSJ-1	88,93	mUBPy	MSJ-1	84092(Tax:10090)	15504(Tax:10090)	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1 : the relation with the proteasome , acrosome , and centrosome in mouse male germ cells .
7651426	0	mYB-1	90,95	dbpA	75,79	mYB-1	dbpA	22608(Tax:10090)	8531	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	Repression of major histocompatibility complex I-A_beta gene expression by dbpA and dbpB -LRB- mYB-1 -RRB- proteins .
12370310	0	mZnf8	18,23	Smad1	116,121	mZnf8	Smad1	243833(Tax:10090)	17125(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|partner partner|nmod|END_ENTITY	Identification of mZnf8 , a mouse Kr ppel-like transcriptional repressor , as a novel nuclear interaction partner of Smad1 .
11400113	0	mac25	58,63	angiomodulin	14,26	mac25	angiomodulin	3490	3490	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of angiomodulin -LRB- tumor-derived_adhesion_factor / mac25 -RRB- in invading tumor cells correlates with poor prognosis in human colorectal_cancer .
2158509	1	macrophage-activating_factor	68,96	IL-3	48,52	macrophage-activating factor	IL-3	17132(Tax:10090)	16187(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	I. IL-3 functions as a macrophage-activating_factor with unique properties , inducing Ia and lymphocyte_function-associated_antigen-1 but not cytotoxicity .
20604722	0	macrophage-colony_stimulating_factor	31,67	M-CSF	69,74	macrophage-colony stimulating factor	M-CSF	1435	1435	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of serum macrophage-colony_stimulating_factor -LRB- M-CSF -RRB- in esophageal_cancer patients and its comparison with classical tumor markers .
23005594	0	macrophage-derived_chemokine	14,42	CCL22	44,49	macrophage-derived chemokine	CCL22	6367	6367	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of macrophage-derived_chemokine -LRB- CCL22 -RRB- in atherosclerosis and regulation by histamine via the H2 receptor .
11876749	0	macrophage-derived_chemokine	6,34	MDC	36,39	macrophage-derived chemokine	MDC	6367	6367	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum macrophage-derived_chemokine -LRB- MDC -RRB- levels are closely related with the disease activity of atopic_dermatitis .
9581805	0	macrophage-derived_chemokine	14,42	MDC	44,47	macrophage-derived chemokine	MDC	6367	6367	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of macrophage-derived_chemokine -LRB- MDC -RRB- mRNA in macrophages is enhanced by interleukin-1beta , tumor_necrosis_factor_alpha , and lipopolysaccharide .
16704642	0	macrophage-derived_chemokine	32,60	interleukin-16	16,30	macrophage-derived chemokine	interleukin-16	6367	3603	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Significance of interleukin-16 , macrophage-derived_chemokine , eosinophil cationic protein and soluble E-selectin in reflecting disease activity of atopic_dermatitis -- from laboratory parameters to clinical scores .
9763548	0	macrophage-derived_chemokine	59,87	interleukin-4	21,34	macrophage-derived chemokine	interleukin-4	6367	3565	Gene	Gene	production|amod|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived_chemokine production : an amplification circuit of polarized T helper 2 responses .
11591793	0	macrophage-inflammatory_protein_2	27,60	MIP-2	62,67	macrophage-inflammatory protein 2	MIP-2	20310(Tax:10090)	20310(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Constitutive expression of macrophage-inflammatory_protein_2 -LRB- MIP-2 -RRB- mRNA in bone marrow gives rise to peripheral neutrophils with preformed MIP-2 protein .
21859424	0	macrophage_activating_factor	40,68	MAF	70,73	macrophage activating factor	MAF	4094	4094	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Phenotype of Gc-globulin influences the macrophage_activating_factor -LRB- MAF -RRB- levels in serum .
3316511	0	macrophage_activating_factor	36,64	MAF	66,69	macrophage activating factor	MAF	4094	4094	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Preparation and antitumor effect of macrophage_activating_factor -LRB- MAF -RRB- encapsulated in liposomes bearing a monoclonal anti-human melanoma -LRB- A375 -RRB- antibody .
6371237	0	macrophage_activation_factor	26,54	MAF	56,59	macrophage activation factor	MAF	4094	4094	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of human macrophage_activation_factor -LRB- MAF -RRB- prepared from antigen-stimulated lymphocytes .
10382942	0	macrophage_colony-stimulating_factor	8,44	CD34	120,124	macrophage colony-stimulating factor	CD34	1435	947	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|cells cells|compound|END_ENTITY	Role of macrophage_colony-stimulating_factor in the differentiation and expansion of monocytes and dendritic cells from CD34 + progenitor cells .
11567999	0	macrophage_colony-stimulating_factor	17,53	Decorin	0,7	macrophage colony-stimulating factor	Decorin	1435	1634	Gene	Gene	proliferation|amod|START_ENTITY inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	Decorin inhibits macrophage_colony-stimulating_factor proliferation of macrophages and enhances cell survival through induction of p27 -LRB- Kip1 -RRB- and p21 -LRB- Waf1 -RRB- .
10632665	0	macrophage_colony-stimulating_factor	11,47	M-CSF	49,54	macrophage colony-stimulating factor	M-CSF	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on anti-fungal activity of mononuclear phagocytes against Trichosporon asahii .
10926834	0	macrophage_colony-stimulating_factor	41,77	M-CSF	79,84	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	cAMP attenuates interleukin-1-stimulated macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- expression .
1581229	0	macrophage_colony-stimulating_factor	35,71	M-CSF	73,78	macrophage colony-stimulating factor	M-CSF	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Epidermal_growth_factor stimulates macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- mRNA expression and M-CSF release in cultured murine stromal cells .
17880962	0	macrophage_colony-stimulating_factor	15,51	M-CSF	53,58	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- in the function of follicular granulosa cells .
1838015	0	macrophage_colony-stimulating_factor	14,50	M-CSF	52,57	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- in two Hodgkin 's Reed-Sternberg -LRB- H-RS -RRB- cell lines , HDLM-1 and KM-H2 , and in H-RS cells in tissues .
8107489	0	macrophage_colony-stimulating_factor	30,66	M-CSF	68,73	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Basal expression of the human macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- gene in K562 cells .
8199046	0	macrophage_colony-stimulating_factor	6,42	M-CSF	44,49	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- levels correlate with clinical response to interferon-alpha in patients with early-stage B-CLL .
8347686	0	macrophage_colony-stimulating_factor	14,50	M-CSF	52,57	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- by human articular cartilage and chondrocytes .
8573750	0	macrophage_colony-stimulating_factor	14,50	M-CSF	52,57	macrophage colony-stimulating factor	M-CSF	78965(Tax:10116)	78965(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on the progression of lipid-induced nephrotoxicity in diabetic_nephropathy .
8929623	0	macrophage_colony-stimulating_factor	100,136	M-CSF	138,143	macrophage colony-stimulating factor	M-CSF	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Neonatal changes of osteoclasts in osteopetrosis -LRB- op/op -RRB- mice defective in production of functional macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- protein and effects of M-CSF on osteoclast development and differentiation .
9543701	0	macrophage_colony-stimulating_factor	10,46	M-CSF	48,53	macrophage colony-stimulating factor	M-CSF	12977(Tax:10090)	12977(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on mouse immune responses in vivo .
9629620	0	macrophage_colony-stimulating_factor	54,90	M-CSF	92,97	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Exposure-based safety evaluation of recombinant human macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- in cynomolgus_monkeys .
9698485	0	macrophage_colony-stimulating_factor	6,42	M-CSF	44,49	macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- levels in patients with epithelial_ovarian_cancer .
1712226	0	macrophage_colony-stimulating_factor	68,104	jun	14,17	macrophage colony-stimulating factor	jun	1435	3725	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of jun and fos gene expression in human monocytes by the macrophage_colony-stimulating_factor .
1912581	0	macrophage_colony-stimulating_factor	73,109	tumor_necrosis_factor	118,139	macrophage colony-stimulating factor	tumor necrosis factor	1435	7124	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Involvement of a nuclear_factor-kappa_B-like protein in induction of the macrophage_colony-stimulating_factor gene by tumor_necrosis_factor .
11297560	0	macrophage_colony-stimulating_factor_receptor	54,99	Suppressor_of_cytokine_signaling_1	0,34	macrophage colony-stimulating factor receptor	Suppressor of cytokine signaling 1	12978(Tax:10090)	12703(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Suppressor_of_cytokine_signaling_1 interacts with the macrophage_colony-stimulating_factor_receptor and negatively regulates its proliferation signal .
7814798	0	macrophage_colony_stimulating_factor	16,52	M-CSF	54,59	macrophage colony stimulating factor	M-CSF	1435	1435	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of macrophage_colony_stimulating_factor -LRB- M-CSF -RRB- in liver_disease .
10993890	0	macrophage_elastase	46,65	MMP-12	67,73	macrophage elastase	MMP-12	17381(Tax:10090)	17381(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Proteinase-activated receptor-1 regulation of macrophage_elastase -LRB- MMP-12 -RRB- secretion by serine proteinases .
15605420	0	macrophage_elastase	13,32	MMP-12	34,40	macrophage elastase	MMP-12	17381(Tax:10090)	17381(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of macrophage_elastase -LRB- MMP-12 -RRB- gene expression by statins .
10964914	0	macrophage_fusion_receptor	23,49	CD47	0,4	macrophage fusion receptor	CD47	140885	961	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	CD47 , a ligand for the macrophage_fusion_receptor , participates in macrophage multinucleation .
7594602	0	macrophage_inflammatory_protein-1_alpha	14,53	IL-10	68,73	macrophage inflammatory protein-1 alpha	IL-10	6348	3586	Gene	Gene	expression|amod|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|END_ENTITY	Inhibition of macrophage_inflammatory_protein-1_alpha expression by IL-10 .
9794606	0	macrophage_inflammatory_protein-1_alpha	67,106	Interleukin-13	0,14	macrophage inflammatory protein-1 alpha	Interleukin-13	6348	3596	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Interleukin-13 down-regulates the expression of neutrophil-derived macrophage_inflammatory_protein-1_alpha .
8810643	0	macrophage_inflammatory_protein-1_alpha	24,63	Interleukin_13	0,14	macrophage inflammatory protein-1 alpha	Interleukin 13	6348	3596	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin_13 inhibits macrophage_inflammatory_protein-1_alpha production from human alveolar macrophages and monocytes .
8843546	0	macrophage_inflammatory_protein-1_alpha	31,70	LD78	72,76	macrophage inflammatory protein-1 alpha	LD78	6348	414062	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The inhibitory effect of human macrophage_inflammatory_protein-1_alpha -LRB- LD78 -RRB- on acute_myeloid_leukemia cells in vitro .
11426325	0	macrophage_inflammatory_protein-1_alpha	29,68	MIP-1alpha	70,80	macrophage inflammatory protein-1 alpha	MIP-1alpha	6348	6348	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Novel polymorphisms in human macrophage_inflammatory_protein-1_alpha -LRB- MIP-1alpha -RRB- gene .
9139699	1	macrophage_inflammatory_protein-1alpha	110,148	CCR-1	160,165	macrophage inflammatory protein-1alpha	CCR-1	20302(Tax:10090)	12768(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Comparison to three other related macrophage_inflammatory_protein-1alpha receptors , CCR-1 , CCR-3 , and CCR-5 .
14746807	0	macrophage_inflammatory_protein-1beta	26,63	Interleukin-1beta	0,17	macrophage inflammatory protein-1beta	Interleukin-1beta	6351	3553	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces macrophage_inflammatory_protein-1beta expression in human hepatocytes .
18623207	0	macrophage_inflammatory_protein-1beta	52,89	monocyte_chemoattractant_protein-1	16,50	macrophage inflammatory protein-1beta	monocyte chemoattractant protein-1	6351	6347	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Increased serum monocyte_chemoattractant_protein-1 , macrophage_inflammatory_protein-1beta , and interleukin-8 concentrations in hemophagocytic_lymphohistiocytosis .
21142721	0	macrophage_inflammatory_protein-2	62,95	MIP-2	97,102	macrophage inflammatory protein-2	MIP-2	114105(Tax:10116)	114105(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Low-level laser therapy associated to N-acetylcysteine lowers macrophage_inflammatory_protein-2 -LRB- MIP-2 -RRB- mRNA expression and generation of intracellular reactive oxygen species in alveolar macrophages .
15132979	0	macrophage_inflammatory_protein-2	16,49	p44	138,141	macrophage inflammatory protein-2	p44	20310(Tax:10090)	26417(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Hypoxia induces macrophage_inflammatory_protein-2 -LRB- MIP-2 -RRB- gene expression in murine macrophages via NF-kappaB : the prominent role of p42 / p44 and PI3 kinase pathways .
8110470	0	macrophage_inflammatory_protein-2	107,140	tumor_necrosis_factor-alpha	78,105	macrophage inflammatory protein-2	tumor necrosis factor-alpha	114105(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Cytokine expression by neutrophils and macrophages in vivo : endotoxin induces tumor_necrosis_factor-alpha , macrophage_inflammatory_protein-2 , interleukin-1_beta , and interleukin-6 but not RANTES or transforming_growth_factor-beta_1 mRNA expression in acute_lung_inflammation .
11809734	0	macrophage_inflammatory_protein-3_alpha	55,94	CCL20	95,100	macrophage inflammatory protein-3 alpha	CCL20	6364	6364	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	Human_T_cell_leukemia_virus_type-I Tax activates human macrophage_inflammatory_protein-3_alpha / CCL20 gene transcription via the NF-kappa_B pathway .
11809734	0	macrophage_inflammatory_protein-3_alpha	55,94	Tax	35,38	macrophage inflammatory protein-3 alpha	Tax	6364	1491938(Tax:11908)	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Human_T_cell_leukemia_virus_type-I Tax activates human macrophage_inflammatory_protein-3_alpha / CCL20 gene transcription via the NF-kappa_B pathway .
11035086	0	macrophage_inflammatory_protein-3_alpha	95,134	liver_and_activation-regulated_chemokine	54,94	macrophage inflammatory protein-3 alpha	liver and activation-regulated chemokine	6364	6364	Gene	Gene	production|dep|START_ENTITY production|nmod|END_ENTITY	Regulated production and molecular diversity of human liver_and_activation-regulated_chemokine / macrophage_inflammatory_protein-3_alpha from normal and transformed cells .
12626344	0	macrophage_inflammatory_protein-3_beta	14,52	CCL19	53,58	macrophage inflammatory protein-3 beta	CCL19	6363	6363	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of macrophage_inflammatory_protein-3_beta / CCL19 in pulmonary_sarcoidosis .
21109018	0	macrophage_inflammatory_protein-3a	105,139	Kruppel-like_factor_6_and_peroxisome_proliferator-activated_receptor-y	13,83	macrophage inflammatory protein-3a	Kruppel-like factor 6 and peroxisome proliferator-activated receptor-y	29538(Tax:10116)	58954(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The roles of Kruppel-like_factor_6_and_peroxisome_proliferator-activated_receptor-y in the regulation of macrophage_inflammatory_protein-3a at early onset of diabetes .
23331383	0	macrophage_inflammatory_protein-3a	57,91	interleukin-1b	11,25	macrophage inflammatory protein-3a	interleukin-1b	6364	3553	Gene	Gene	production|amod|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of interleukin-1b and tumor_necrosis_factor-a on macrophage_inflammatory_protein-3a production in synovial fibroblast-like cells from human temporomandibular_joints .
11698482	0	macrophage_inflammatory_protein-3alpha	50,88	IL-1	20,24	macrophage inflammatory protein-3alpha	IL-1	6364	3553	Gene	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Enhancing effect of IL-1 , IL-17 , and TNF-alpha on macrophage_inflammatory_protein-3alpha production in rheumatoid_arthritis : regulation by soluble receptors and Th2 cytokines .
7535702	0	macrophage_inflammatory_protein_1_alpha	74,113	CD8	0,3	macrophage inflammatory protein 1 alpha	CD8	6348	925	Gene	Gene	sources|nmod|START_ENTITY sources|nsubj|+ +|compound|END_ENTITY	CD8 + and CD45RA + human peripheral blood lymphocytes are potent sources of macrophage_inflammatory_protein_1_alpha , interleukin-8 and RANTES .
12488501	0	macrophage_inflammatory_protein_1alpha	21,59	CCL3	60,64	macrophage inflammatory protein 1alpha	CCL3	20302(Tax:10090)	20302(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	An essential role of macrophage_inflammatory_protein_1alpha / CCL3 on the expression of host 's innate immunities against infectious_complications .
11152502	0	macrophage_inflammatory_protein_2	23,56	MIP-2	58,63	macrophage inflammatory protein 2	MIP-2	20310(Tax:10090)	20310(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Enhanced production of macrophage_inflammatory_protein_2 -LRB- MIP-2 -RRB- by in vitro and in vivo infections with encephalomyocarditis_virus and modulation of myocarditis with an antibody against MIP-2 .
8553267	0	macrophage_inflammatory_protein_2	13,46	interleukin_1_beta	66,84	macrophage inflammatory protein 2	interleukin 1 beta	114105(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of macrophage_inflammatory_protein_2 gene expression by interleukin_1_beta in rat lung .
9294138	0	macrophage_inflammatory_protein_3alpha	50,88	CCR6	0,4	macrophage inflammatory protein 3alpha	CCR6	6364	1235	Gene	Gene	interacts|nmod|START_ENTITY receptor|acl:relcl|interacts END_ENTITY|appos|receptor	CCR6 , a CC chemokine receptor that interacts with macrophage_inflammatory_protein_3alpha and is highly expressed in human dendritic cells .
11532377	0	macrophage_inflammatory_protein_3alpha	83,121	TNF-alpha	49,58	macrophage inflammatory protein 3alpha	TNF-alpha	6364	7124	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Differentiated keratinocytes are responsible for TNF-alpha regulated production of macrophage_inflammatory_protein_3alpha / CCL20 , a potent chemokine for Langerhans cells .
19133249	0	macrophage_inhibitory_cytokine-1	30,62	MIC-1	64,69	macrophage inhibitory cytokine-1	MIC-1	9518	9518	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation and secretion of macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- in gastric_cancers .
23836903	0	macrophage_inhibitory_cytokine-1	58,90	MIC-1	92,97	macrophage inhibitory cytokine-1	MIC-1	9518	9518	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	RNPC1 , an RNA-binding protein and a p53 target , regulates macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- expression through mRNA stability .
23836903	0	macrophage_inhibitory_cytokine-1	58,90	RNPC1	0,5	macrophage inhibitory cytokine-1	RNPC1	9518	55544	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNPC1 , an RNA-binding protein and a p53 target , regulates macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- expression through mRNA stability .
14726168	0	macrophage_inhibitory_cytokine_1	24,56	MIC_1	58,63	macrophage inhibitory cytokine 1	MIC 1	9518	9518	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of macrophage_inhibitory_cytokine_1 -LRB- MIC_1 -RRB- as a predictor of miscarriage .
19530702	0	macrophage_inhibitory_factor	14,42	MIF	44,47	macrophage inhibitory factor	MIF	4282	4282	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of macrophage_inhibitory_factor -LRB- MIF -RRB- by epidermal_growth_factor_receptor -LRB- EGFR -RRB- in the MCF10AT model of breast_cancer_progression .
19530702	0	macrophage_inhibitory_factor	14,42	epidermal_growth_factor_receptor	52,84	macrophage inhibitory factor	epidermal growth factor receptor	4282	1956	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of macrophage_inhibitory_factor -LRB- MIF -RRB- by epidermal_growth_factor_receptor -LRB- EGFR -RRB- in the MCF10AT model of breast_cancer_progression .
24272203	0	macrophage_migration-inhibitory_factor	16,54	MIF	56,59	macrophage migration-inhibitory factor	MIF	4282	4282	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of macrophage_migration-inhibitory_factor -LRB- MIF -RRB- have diagnostic , predictive and prognostic roles in epithelial_ovarian_cancer patients .
17362525	0	macrophage_migration_inhibitory_factor	62,100	C-reactive_protein	14,32	macrophage migration inhibitory factor	C-reactive protein	4282	1401	Gene	Gene	receptor|dep|START_ENTITY receptor|compound|END_ENTITY	Use of plasma C-reactive_protein , procalcitonin , neutrophils , macrophage_migration_inhibitory_factor , soluble urokinase-type plasminogen activator receptor , and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections : a prospective study .
17142775	0	macrophage_migration_inhibitory_factor	14,52	CD74	70,74	macrophage migration inhibitory factor	CD74	4282	972	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of macrophage_migration_inhibitory_factor or its receptor -LRB- CD74 -RRB- attenuates growth and invasion of DU-145_prostate_cancer cells .
19131591	0	macrophage_migration_inhibitory_factor	37,75	CD74	14,18	macrophage migration inhibitory factor	CD74	4282	972	Gene	Gene	receptor|nmod|START_ENTITY Expression|appos|receptor Expression|nmod|END_ENTITY	Expression of CD74 , the receptor for macrophage_migration_inhibitory_factor , in non-small cell lung_cancer .
19325914	0	macrophage_migration_inhibitory_factor	68,106	CD74	49,53	macrophage migration inhibitory factor	CD74	103694877	25599(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|dep|receptor	Substance P increases cell-surface expression of CD74 -LRB- receptor for macrophage_migration_inhibitory_factor -RRB- : in vivo biotinylation of urothelial cell-surface proteins .
24939415	0	macrophage_migration_inhibitory_factor	15,53	CD74	72,76	macrophage migration inhibitory factor	CD74	4282	972	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of macrophage_migration_inhibitory_factor and its receptor -LRB- CD74 -RRB- in human breast_cancer .
16854377	0	macrophage_migration_inhibitory_factor	19,57	CREB	89,93	macrophage migration inhibitory factor	CREB	4282	1385	Gene	Gene	regulation|nmod|START_ENTITY expression|nsubj|regulation expression|nmod|END_ENTITY	Dual regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in hypoxia by CREB and HIF-1 .
10079069	0	macrophage_migration_inhibitory_factor	68,106	D-dopachrome_tautomerase	27,51	macrophage migration inhibitory factor	D-dopachrome tautomerase	4282	1652	Gene	Gene	homologue|nmod|START_ENTITY structure|appos|homologue structure|nmod|END_ENTITY	Crystal structure of human D-dopachrome_tautomerase , a homologue of macrophage_migration_inhibitory_factor , at 1.54 A resolution .
21817065	0	macrophage_migration_inhibitory_factor	88,126	D-dopachrome_tautomerase	4,28	macrophage migration inhibitory factor	D-dopachrome tautomerase	17319(Tax:10090)	13202(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|product product|amod|END_ENTITY	The D-dopachrome_tautomerase -LRB- DDT -RRB- gene product is a cytokine and functional homolog of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- .
24356968	0	macrophage_migration_inhibitory_factor	98,136	D-dopachrome_tautomerase	13,37	macrophage migration inhibitory factor	D-dopachrome tautomerase	4282	1652	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Dysregulated D-dopachrome_tautomerase , a hypoxia-inducible factor-dependent gene , cooperates with macrophage_migration_inhibitory_factor in renal tumorigenesis .
16188240	0	macrophage_migration_inhibitory_factor	37,75	ERK2	80,84	macrophage migration inhibitory factor	ERK2	17319(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nummod|END_ENTITY	Ursolic_acid promotes the release of macrophage_migration_inhibitory_factor via ERK2 activation in resting mouse macrophages .
15012733	0	macrophage_migration_inhibitory_factor	25,63	Interferon-gamma	0,16	macrophage migration inhibitory factor	Interferon-gamma	103694877	25712(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Interferon-gamma induces macrophage_migration_inhibitory_factor synthesis and secretion by tubular epithelial cells .
10404515	0	macrophage_migration_inhibitory_factor	22,60	MIF	62,65	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	An essential role for macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in angiogenesis and the growth of a murine lymphoma .
10415161	0	macrophage_migration_inhibitory_factor	14,52	MIF	54,57	macrophage migration inhibitory factor	MIF	103694877	81683(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression by glucose and insulin in adipocytes in vitro .
10576686	0	macrophage_migration_inhibitory_factor	14,52	MIF	54,57	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- tautomerase activity by dopachrome analogs .
10776792	0	macrophage_migration_inhibitory_factor	23,61	MIF	63,66	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	Different influence of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in signal transduction pathway of various T cell subsets .
10865055	0	macrophage_migration_inhibitory_factor	44,82	MIF	84,87	macrophage migration inhibitory factor	MIF	103694877	103694877	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Expression and glucocorticoid regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in hippocampal and neocortical rat brain cells in culture .
10877450	0	macrophage_migration_inhibitory_factor	8,46	MIF	48,51	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in allergic and endotoxin-induced airway inflammation in mice .
11118621	0	macrophage_migration_inhibitory_factor	55,93	MIF	95,98	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Japanese_encephalitis_virus up-regulates expression of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- mRNA in the mouse brain .
11126199	0	macrophage_migration_inhibitory_factor	15,53	MIF	55,58	macrophage migration inhibitory factor	MIF	103694877	81683(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in experimental uric_acid nephropathy .
11773615	0	macrophage_migration_inhibitory_factor	14,52	MIF	54,57	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- tautomerase and biological activities by acetaminophen metabolites .
12070782	0	macrophage_migration_inhibitory_factor	42,80	MIF	82,85	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A functional promoter polymorphism in the macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene associated with disease severity in rheumatoid_arthritis .
14574584	0	macrophage_migration_inhibitory_factor	36,74	MIF	76,79	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in human gingival tissue and its pathophysiological functions .
15654833	0	macrophage_migration_inhibitory_factor	9,47	MIF	49,52	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Elevated macrophage_migration_inhibitory_factor -LRB- MIF -RRB- levels in the urine of patients with focal_glomerular_sclerosis .
15659324	0	macrophage_migration_inhibitory_factor	8,46	MIF	48,51	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in the skin .
15821118	0	macrophage_migration_inhibitory_factor	25,63	MIF	65,68	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucocorticoids suppress macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in a cell-type-specific manner .
16077028	0	macrophage_migration_inhibitory_factor	65,103	MIF	105,108	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Simultaneous detection of microsatellite repeats and SNPs in the macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene by thin-film biosensor chips and application to rural field studies .
16461006	0	macrophage_migration_inhibitory_factor	22,60	MIF	62,65	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Decreased circulating macrophage_migration_inhibitory_factor -LRB- MIF -RRB- protein and blood mononuclear cell MIF transcripts in children with Plasmodium_falciparum_malaria .
16682188	0	macrophage_migration_inhibitory_factor	78,116	MIF	118,121	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- tautomerase activity .
16854377	0	macrophage_migration_inhibitory_factor	19,57	MIF	59,62	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Dual regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in hypoxia by CREB and HIF-1 .
16860715	0	macrophage_migration_inhibitory_factor	10,48	MIF	50,53	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- on acute_graft-versus-host_disease in a murine model of allogeneic stem cell transplantation .
18081874	0	macrophage_migration_inhibitory_factor	6,44	MIF	46,49	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum macrophage_migration_inhibitory_factor -LRB- MIF -RRB- levels after allogeneic hematopoietic stem cell transplantation .
18347935	0	macrophage_migration_inhibitory_factor	24,62	MIF	64,67	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The diagnostic value of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in gastric_cancer .
19394321	0	macrophage_migration_inhibitory_factor	12,50	MIF	52,55	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Increase of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in cardiomyocytes during chronic hypoxia .
19464392	0	macrophage_migration_inhibitory_factor	12,50	MIF	52,55	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in patients with idiopathic_pulmonary_fibrosis .
19602265	0	macrophage_migration_inhibitory_factor	13,51	MIF	53,56	Macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Dual role of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in human breast_cancer .
19747950	0	macrophage_migration_inhibitory_factor	39,77	MIF	79,82	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Histone deacetylase inhibitors repress macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression by targeting MIF gene transcription through a local chromatin deacetylation .
20093039	0	macrophage_migration_inhibitory_factor	62,100	MIF	102,105	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization and functional analysis of porcine macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene .
20169062	0	macrophage_migration_inhibitory_factor	27,65	MIF	67,70	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in melioidosis .
20621719	0	macrophage_migration_inhibitory_factor	57,95	MIF	97,100	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between functional promoter polymorphisms of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- gene and ulcerative_colitis in Japan .
21536912	0	macrophage_migration_inhibitory_factor	50,88	MIF	90,93	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Thyroxine is a potential endogenous antagonist of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- activity .
21641401	0	macrophage_migration_inhibitory_factor	10,48	MIF	50,53	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in human placental explants infected with Toxoplasma_gondii depends on gestational age .
21730129	0	macrophage_migration_inhibitory_factor	18,56	MIF	58,61	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role for macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in Ross_River_virus-induced arthritis and myositis .
22476444	0	macrophage_migration_inhibitory_factor	29,67	MIF	69,72	macrophage migration inhibitory factor	MIF	595146(Tax:9615)	595146(Tax:9615)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in feeding American dog ticks , Dermacentor variabilis .
23721694	0	macrophage_migration_inhibitory_factor	19,57	MIF	59,62	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A genetic role for macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in adult-onset_Still 's _ disease .
24916123	0	macrophage_migration_inhibitory_factor	21,59	MIF	61,64	macrophage migration inhibitory factor	MIF	4282	4282	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Potent inhibition of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- by myeloperoxidase-dependent oxidation of epicatechins .
9203559	0	macrophage_migration_inhibitory_factor	36,74	MIF	76,79	macrophage migration inhibitory factor	MIF	103694877	81683(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in tanycytes , subcommissural organ and choroid plexus in the rat brain .
9932108	0	macrophage_migration_inhibitory_factor	15,53	MIF	55,58	macrophage migration inhibitory factor	MIF	17319(Tax:10090)	17319(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- in the mechanism of tumor cell growth .
14960229	0	macrophage_migration_inhibitory_factor	11,49	MMP-2	73,78	macrophage migration inhibitory factor	MMP-2	4282	4313	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of macrophage_migration_inhibitory_factor -LRB- MIF -RRB- on expression of MMP-2 , MMP-9 , and IL-8 in nasopharyngeal_carcinoma cell strains -RSB- .
24379579	0	macrophage_migration_inhibitory_factor	64,102	P115	0,4	macrophage migration inhibitory factor	P115	4282	8615	Gene	Gene	interaction|nmod|START_ENTITY promotes|nmod|interaction promotes|nsubj|END_ENTITY	P115 promotes growth of gastric_cancer through interaction with macrophage_migration_inhibitory_factor .
10353846	0	macrophage_migration_inhibitory_factor	9,47	Pro-1	0,5	macrophage migration inhibitory factor	Pro-1	4282	4000	Gene	Gene	functions|compound|START_ENTITY END_ENTITY|nmod|functions	Pro-1 of macrophage_migration_inhibitory_factor functions as a catalytic base in the phenylpyruvate_tautomerase activity .
19155217	0	macrophage_migration_inhibitory_factor	37,75	Ribosomal_protein_S19	0,21	macrophage migration inhibitory factor	Ribosomal protein S19	4282	6223	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Ribosomal_protein_S19 interacts with macrophage_migration_inhibitory_factor and attenuates its pro-inflammatory function .
24066135	0	macrophage_migration_inhibitory_factor	22,60	Sox6	0,4	macrophage migration inhibitory factor	Sox6	17319(Tax:10090)	20679(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Sox6 up-regulation by macrophage_migration_inhibitory_factor promotes survival and maintenance of mouse neural stem/progenitor cells .
16283355	0	macrophage_migration_inhibitory_factor	64,102	Toll-like_receptor_4	14,34	macrophage migration inhibitory factor	Toll-like receptor 4	17319(Tax:10090)	21898(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of Toll-like_receptor_4 expression in mouse colon by macrophage_migration_inhibitory_factor .
9538268	0	macrophage_migration_inhibitory_factor	61,99	Tumor_necrosis_factor-alpha	0,27	macrophage migration inhibitory factor	Tumor necrosis factor-alpha	4282	7124	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates the gene expression of macrophage_migration_inhibitory_factor through tyrosine kinase-dependent pathway in 3T3-L1 adipocytes .
11606427	0	macrophage_migration_inhibitory_factor	14,52	angiotensin_II	56,70	macrophage migration inhibitory factor	angiotensin II	103694877	24179(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|amod|END_ENTITY	Novel role of macrophage_migration_inhibitory_factor in angiotensin_II regulation of neuromodulation in rat brain .
12823441	0	macrophage_migration_inhibitory_factor	114,152	d-dopachrome_tautomerase	41,65	macrophage migration inhibitory factor	d-dopachrome tautomerase	4282	1652	Gene	Gene	correlates|nmod|START_ENTITY activity|acl:relcl|correlates activity|amod|END_ENTITY	UVB-induced inflammation gives increased d-dopachrome_tautomerase activity in blister fluid which correlates with macrophage_migration_inhibitory_factor .
12847682	0	macrophage_migration_inhibitory_factor	21,59	p53	14,17	macrophage migration inhibitory factor	p53	17319(Tax:10090)	22060(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of p53 by macrophage_migration_inhibitory_factor in inflammatory_arthritis .
20922580	0	macrophage_migration_inhibitory_factor	36,74	p53	97,100	macrophage migration inhibitory factor	p53	4282	7157	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinicopathological significance of macrophage_migration_inhibitory_factor and its relation with p53 in gastric_cancer .
10933783	0	macrophage_migration_inhibitory_factor	56,94	phenylpyruvate_tautomerase	17,43	macrophage migration inhibitory factor	phenylpyruvate tautomerase	4282	4282	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Mechanism of the phenylpyruvate_tautomerase activity of macrophage_migration_inhibitory_factor : properties of the P1G , P1A , Y95F , and N97A mutants .
16780921	0	macrophage_migration_inhibitory_factor	59,97	phenylpyruvate_tautomerase	20,46	macrophage migration inhibitory factor	phenylpyruvate tautomerase	4282	4282	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inactivation of the phenylpyruvate_tautomerase activity of macrophage_migration_inhibitory_factor by 2-oxo-4-phenyl-3-butynoate .
11407686	0	macrophage_migration_inhibitory_factor	67,105	phospholipase_A2	26,42	macrophage migration inhibitory factor	phospholipase A2	4282	151056	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of synoviocyte phospholipase_A2 and cyclooxygenase_2 by macrophage_migration_inhibitory_factor .
16861224	0	macrophage_migration_inhibitory_factor	30,68	tumor_necrosis_factor-alpha	91,118	macrophage migration inhibitory factor	tumor necrosis factor-alpha	4282	7124	Gene	Gene	neutrophils|dobj|START_ENTITY neutrophils|nmod|stimulation stimulation|nmod|END_ENTITY	Apoptotic neutrophils release macrophage_migration_inhibitory_factor upon stimulation with tumor_necrosis_factor-alpha .
9196042	0	macrophage_migration_inhibitory_factor	18,56	tumor_necrosis_factor-alpha	96,123	macrophage migration inhibitory factor	tumor necrosis factor-alpha	103694877	24835(Tax:10116)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of macrophage_migration_inhibitory_factor in adipose tissue and its induction by tumor_necrosis_factor-alpha .
15260083	0	macrophage_scavenger_receptor_1	27,58	MSR1	60,64	macrophage scavenger receptor 1	MSR1	4481	4481	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the macrophage_scavenger_receptor_1 -LRB- MSR1 -RRB- gene in primary lung_cancer .
6999821	0	macrophage_slowing_factor	27,52	MSF	22,25	macrophage slowing factor	MSF	10216	10216	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of the MSF -LRB- macrophage_slowing_factor -RRB- release by phytohemagglutinin using the macrophage electrophoretic mobility test -LRB- MEM test -RRB- .
20201372	0	mad1	86,90	C-myc	79,84	mad1	C-myc	4084	4609	Gene	Gene	p53|dep|START_ENTITY p53|compound|END_ENTITY	-LSB- Development of a set of diagnostic test systems for analysis of expression of C-myc , mad1 , max , p53 , and E2F1 gene oncomarkers by the reverse transcription reaction-polymerase chain reaction alignment technique -RSB- .
20201372	0	mad1	86,90	max	92,95	mad1	max	4084	4149	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	-LSB- Development of a set of diagnostic test systems for analysis of expression of C-myc , mad1 , max , p53 , and E2F1 gene oncomarkers by the reverse transcription reaction-polymerase chain reaction alignment technique -RSB- .
16086584	0	madindoline_A	11,24	gp130	56,61	madindoline A	gp130	270	3572	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of madindoline_A to the extracellular domain of gp130 .
11013233	0	maf	6,9	MafG	11,15	maf	MafG	4094	4097	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Small maf -LRB- MafG and MafK -RRB- proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD -LRB- P -RRB- H : Quinone_oxidoreductase1 gene .
10656761	0	mag-1	0,5	mago_nashi	31,41	mag-1	mago nashi	173073(Tax:6239)	37402(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	mag-1 , a homolog of Drosophila mago_nashi , regulates hermaphrodite_germ-line_sex_determination in Caenorhabditis_elegans .
10656761	0	mago_nashi	31,41	mag-1	0,5	mago nashi	mag-1	37402(Tax:7227)	173073(Tax:6239)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	mag-1 , a homolog of Drosophila mago_nashi , regulates hermaphrodite_germ-line_sex_determination in Caenorhabditis_elegans .
3286127	0	main_intrinsic_polypeptide	23,49	MIP26	51,56	main intrinsic polypeptide	MIP26	4284	4284	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Proteolytic changes in main_intrinsic_polypeptide -LRB- MIP26 -RRB- from membranes in selenite cataract .
11852078	0	main_intrinsic_protein	46,68	MIP	70,73	main intrinsic protein	MIP	25480(Tax:10116)	25480(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Heterologous expression and topography of the main_intrinsic_protein -LRB- MIP -RRB- from rat lens .
9813227	0	major_capsid_protein	26,46	mcp	48,51	major capsid protein	mcp	4179	4179	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and sequencing of major_capsid_protein -LRB- mcp -RRB- gene of a vibriophage , KVP20 , possibly related to T-even coliphages .
2503068	0	major_histocompatibility_complex	30,62	Interferon-gamma	0,16	major histocompatibility complex	Interferon-gamma	515712(Tax:9913)	281237(Tax:9913)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Interferon-gamma induction of major_histocompatibility_complex antigens on cultured bovine luteal cells .
18208618	0	major_histocompatibility_complex_class_I-related_chain_A	25,81	MICA	83,87	major histocompatibility complex class I-related chain A	MICA	100507436	100507436	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Augmented serum level of major_histocompatibility_complex_class_I-related_chain_A -LRB- MICA -RRB- protein and reduced NKG2D expression on NK and T cells in patients with cervical_cancer and precursor lesions .
15529349	0	major_histocompatibility_complex_class_I_chain-related_gene_A	45,106	CD8	13,16	major histocompatibility complex class I chain-related gene A	CD8	100507436	925	Gene	Gene	+|nmod|START_ENTITY +|nsubj|END_ENTITY	Autoreactive CD8 + cytotoxic T lymphocytes to major_histocompatibility_complex_class_I_chain-related_gene_A in patients with Beh et 's disease .
21664939	0	major_histocompatibility_complex_class_I_chain-related_gene_B	24,85	MICB	87,91	major histocompatibility complex class I chain-related gene B	MICB	4277	4277	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Characterization of the major_histocompatibility_complex_class_I_chain-related_gene_B -LRB- MICB -RRB- polymorphism in a northern Chinese Han population : the identification of a new MICB allele , MICB * 023 .
16906033	0	major_histocompatibility_complex_class_I_chain-related_molecule_A	32,97	MICA	99,103	major histocompatibility complex class I chain-related molecule A	MICA	100507436	100507436	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The predictive value of soluble major_histocompatibility_complex_class_I_chain-related_molecule_A -LRB- MICA -RRB- levels on heart allograft rejection .
6549044	0	major_urinary_protein	30,51	MUP	53,56	major urinary protein	MUP	381531(Tax:10090)	381531(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Tissue-specific expression of major_urinary_protein -LRB- MUP -RRB- genes in mice : characterization of MUP mRNAs by restriction mapping of cDNA and by in vitro translation .
15749954	0	major_vault_protein	46,65	MVP	67,70	major vault protein	MVP	9961	9961	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Expression and proteasomal degradation of the major_vault_protein -LRB- MVP -RRB- in mammalian oocytes and zygotes .
26175221	0	makorin_ring-finger_protein-3	12,41	MKRN3	43,48	makorin ring-finger protein-3	MKRN3	7681	7681	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels in healthy men and in men with hypogonadotropic_hypogonadism .
26175221	0	makorin_ring-finger_protein-3	12,41	MKRN3	43,48	makorin ring-finger protein-3	MKRN3	7681	7681	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels in healthy men and in men with hypogonadotropic_hypogonadism .
26970436	0	makorin_ring-finger_protein-3	12,41	MKRN3	43,48	makorin ring-finger protein-3	MKRN3	7681	7681	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels in healthy men and in men with hypogonadotropic_hypogonadism .
27025240	0	makorin_ring-finger_protein-3	12,41	MKRN3	43,48	makorin ring-finger protein-3	MKRN3	7681	7681	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating makorin_ring-finger_protein-3 -LRB- MKRN3 -RRB- levels decline in boys before the clinical onset of puberty .
9299784	0	malate_dehydrogenase	28,48	MDH2	50,54	malate dehydrogenase	MDH2	853994(Tax:4932)	853994(Tax:4932)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of cytosolic malate_dehydrogenase -LRB- MDH2 -RRB- causes overproduction of specific organic acids in Saccharomyces_cerevisiae .
19229245	0	malate_dehydrogenase	20,40	p53	51,54	malate dehydrogenase	p53	4199	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	A nucleocytoplasmic malate_dehydrogenase regulates p53 transcriptional activity in response to metabolic stress .
7115281	0	malate_dehydrogenase-like_enzyme	31,63	MDL-1	65,70	malate dehydrogenase-like enzyme	MDL-1	24551(Tax:10116)	24551(Tax:10116)	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	A new genetic variation of the malate_dehydrogenase-like_enzyme -LRB- MDL-1 -RRB- in inbred rats and its possible linkage .
21642471	0	maleylacetoacetate_isomerase	58,86	glutathione_transferase_zeta_1	27,57	maleylacetoacetate isomerase	glutathione transferase zeta 1	2954	2954	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Human polymorphisms in the glutathione_transferase_zeta_1 / maleylacetoacetate_isomerase gene influence the toxicokinetics of dichloroacetate .
22445368	0	malic_enzyme_1	28,42	ME1	45,48	malic enzyme 1	ME1	100860863	100860863	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the caprine malic_enzyme_1 -LRB- ME1 -RRB- gene and its association with milk quality traits in Murciano-Granadina goats .
8944003	0	malignant_melanoma_metastasis-suppressor	22,62	KiSS-1	0,6	malignant melanoma metastasis-suppressor	KiSS-1	3814	3814	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	KiSS-1 , a novel human malignant_melanoma_metastasis-suppressor gene .
19892702	0	malin	45,50	CHIP	13,17	malin	CHIP	378884	358	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Co-chaperone CHIP stabilizes aggregate-prone malin , a ubiquitin ligase mutated in Lafora_disease .
21798009	0	malin	35,40	TRIM32	55,61	malin	TRIM32	378884	22954	Gene	Gene	related|nsubjpass|START_ENTITY related|xcomp|END_ENTITY	Lafora_disease E3-ubiquitin ligase malin is related to TRIM32 at both the phylogenetic and functional level .
21742036	0	malin	32,37	neuronatin	74,84	malin	neuronatin	378884	4826	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|degradation degradation|nmod|END_ENTITY	Lafora_disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis .
19285014	0	mammalian_Target_Of_Rapamycin	43,72	mTOR	74,78	mammalian Target Of Rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	The serine 2481-autophosphorylated form of mammalian_Target_Of_Rapamycin -LRB- mTOR -RRB- is localized to midzone and midbody in dividing cancer cells .
16503349	0	mammalian_achaete_scute-like_homologue_2	49,89	Mash2	91,96	mammalian achaete scute-like homologue 2	Mash2	430	430	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the placenta specific bovine mammalian_achaete_scute-like_homologue_2 -LRB- Mash2 -RRB- gene .
8694785	0	mammalian_disintegrin-metalloprotease	50,87	MADM	21,25	mammalian disintegrin-metalloprotease	MADM	102	29959	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of MADM : a catalytically active mammalian_disintegrin-metalloprotease expressed in various cell types .
25031323	0	mammalian_enabled	61,78	Mena	80,84	mammalian enabled	Mena	55740	55740	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Dynamin1 is a novel target for IRSp53 protein and works with mammalian_enabled -LRB- Mena -RRB- protein and Eps8 to regulate filopodial dynamics .
21307309	0	mammalian_target_of_Rapamycin	40,69	mTORC1	81,87	mammalian target of Rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	I|amod|START_ENTITY inhibition|nmod|I inhibition|appos|END_ENTITY	Selective pharmacogenetic inhibition of mammalian_target_of_Rapamycin complex I -LRB- mTORC1 -RRB- blocks long-term synaptic plasticity and memory storage .
19439225	0	mammalian_target_of_rapamycin	98,127	Activating_transcription_factor_4	0,33	mammalian target of rapamycin	Activating transcription factor 4	2475	468	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Activating_transcription_factor_4 and CCAAT/enhancer-binding _ protein-beta negatively regulate the mammalian_target_of_rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress .
16027121	0	mammalian_target_of_rapamycin	18,47	Akt	0,3	mammalian target of rapamycin	Akt	2475	207	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Akt activates the mammalian_target_of_rapamycin by regulating cellular ATP level and AMPK activity .
24078700	0	mammalian_target_of_rapamycin	10,39	CD4	92,95	mammalian target of rapamycin	CD4	2475	920	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|signaling signaling|compound|END_ENTITY	Increased mammalian_target_of_rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function .
15802268	0	mammalian_target_of_rapamycin	178,207	CXC_chemokine_receptor_4	58,82	mammalian target of rapamycin	CXC chemokine receptor 4	2475	7852	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Epidermal_growth_factor and hypoxia-induced expression of CXC_chemokine_receptor_4 on non-small_cell_lung_cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT / mammalian_target_of_rapamycin signaling pathway and activation of hypoxia_inducible_factor-1alpha .
15802268	0	mammalian_target_of_rapamycin	178,207	Epidermal_growth_factor	0,23	mammalian target of rapamycin	Epidermal growth factor	2475	1950	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Epidermal_growth_factor and hypoxia-induced expression of CXC_chemokine_receptor_4 on non-small_cell_lung_cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT / mammalian_target_of_rapamycin signaling pathway and activation of hypoxia_inducible_factor-1alpha .
18474609	0	mammalian_target_of_rapamycin	124,153	FMRP	72,76	mammalian target of rapamycin	FMRP	2475	2332	Gene	Gene	fragile_X_mental_retardation_protein|nmod|START_ENTITY fragile_X_mental_retardation_protein|appos|END_ENTITY	S6K1 phosphorylates and regulates fragile_X_mental_retardation_protein -LRB- FMRP -RRB- with the neuronal protein synthesis-dependent mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling cascade .
17967941	0	mammalian_target_of_rapamycin	23,52	Foxp3	76,81	mammalian target of rapamycin	Foxp3	2475	50943	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Differential impact of mammalian_target_of_rapamycin inhibition on CD4 + CD25 + Foxp3 + regulatory T cells compared with conventional CD4 + T cells .
17273797	0	mammalian_target_of_rapamycin	16,45	GADD34	0,6	mammalian target of rapamycin	GADD34	2475	23645	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	GADD34 inhibits mammalian_target_of_rapamycin signaling via tuberous_sclerosis_complex and controls cell survival under bioenergetic stress .
17502379	0	mammalian_target_of_rapamycin	52,81	Hypoxia-inducible_factor_1alpha	0,31	mammalian target of rapamycin	Hypoxia-inducible factor 1alpha	2475	3091	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Hypoxia-inducible_factor_1alpha is regulated by the mammalian_target_of_rapamycin -LRB- mTOR -RRB- via an mTOR signaling motif .
17616684	0	mammalian_target_of_rapamycin	14,43	I_kappa_B_kinase_alpha	95,117	mammalian target of rapamycin	I kappa B kinase alpha	2475	1147	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of mammalian_target_of_rapamycin activity in PTEN-inactive prostate_cancer cells by I_kappa_B_kinase_alpha .
21078910	0	mammalian_target_of_rapamycin	95,124	Leptin	0,6	mammalian target of rapamycin	Leptin	2475	3952	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Leptin modulates the survival of autoreactive CD4 + T cells through the nutrient/energy-sensing mammalian_target_of_rapamycin signaling pathway .
21907263	0	mammalian_target_of_rapamycin	12,41	MTOR	43,47	mammalian target of rapamycin	MTOR	2475	2475	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Mechanistic mammalian_target_of_rapamycin -LRB- MTOR -RRB- cell signaling : effects of select nutrients and secreted_phosphoprotein_1 on development of mammalian conceptuses .
25109390	0	mammalian_target_of_rapamycin	53,82	MicroRNA-100	0,12	mammalian target of rapamycin	MicroRNA-100	2475	406892	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-100 promotes migration and invasion through mammalian_target_of_rapamycin in esophageal_squamous_cell_carcinoma .
24774073	0	mammalian_target_of_rapamycin	58,87	MuRF-1	178,184	mammalian target of rapamycin	MuRF-1	2475	84676	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	b-Hydroxy-b-methylbutyrate facilitates PI3K/Akt-dependent mammalian_target_of_rapamycin and FoxO1/3a phosphorylations and alleviates tumor_necrosis_factor_a / interferon y-induced MuRF-1 expression in C2C12 cells .
16651424	0	mammalian_target_of_rapamycin	30,59	Notch1	22,28	mammalian target of rapamycin	Notch1	2475	4851	Gene	Gene	signaling|dep|START_ENTITY signaling|nmod|END_ENTITY	Survival signaling by Notch1 : mammalian_target_of_rapamycin -LRB- mTOR -RRB- - dependent inhibition of p53 .
17565979	0	mammalian_target_of_rapamycin	13,42	P-Rex1	0,6	mammalian target of rapamycin	P-Rex1	2475	57580	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	P-Rex1 links mammalian_target_of_rapamycin signaling to Rac activation and cell migration .
20522531	0	mammalian_target_of_rapamycin	52,81	PI3K	102,106	mammalian target of rapamycin	PI3K	2475	5290	Gene	Gene	inhibitor|compound|START_ENTITY WJD008|appos|inhibitor prevents|nsubj|WJD008 prevents|dobj|signaling signaling|compound|END_ENTITY	WJD008 , a dual phosphatidylinositol 3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin inhibitor , prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant .
20522531	0	mammalian_target_of_rapamycin	52,81	PI3K	46,50	mammalian target of rapamycin	PI3K	2475	5290	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|3-kinase 3-kinase|dep|END_ENTITY	WJD008 , a dual phosphatidylinositol 3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin inhibitor , prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant .
20797855	0	mammalian_target_of_rapamycin	73,102	PI3K	67,71	mammalian target of rapamycin	PI3K	2475	5293	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
21714526	0	mammalian_target_of_rapamycin	69,98	PI3K	63,67	mammalian target of rapamycin	PI3K	2475	5293	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure-activity relationships of phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors : investigations of various 6,5-heterocycles to improve metabolic stability .
26298499	0	mammalian_target_of_rapamycin	102,131	PI3K	96,100	mammalian target of rapamycin	PI3K	2475	5293	Gene	Gene	START_ENTITY|amod|scaffold scaffold|nmod|/ /|appos|END_ENTITY	The imidazo -LSB- 1,2-a -RSB- pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors .
23440206	0	mammalian_target_of_rapamycin	40,69	PML	0,3	mammalian target of rapamycin	PML	2475	5371	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	PML mediates glioblastoma resistance to mammalian_target_of_rapamycin -LRB- mTOR -RRB- - targeted therapies .
18372248	0	mammalian_target_of_rapamycin	72,101	PRAS40	52,58	mammalian target of rapamycin	PRAS40	2475	84335	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Regulation of proline-rich_Akt_substrate_of_40_kDa -LRB- PRAS40 -RRB- function by mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- - mediated phosphorylation .
21622984	0	mammalian_target_of_rapamycin	43,72	Phospholipase_D	0,15	mammalian target of rapamycin	Phospholipase D	2475	2822	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Phospholipase_D mediates nutrient input to mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- .
19439225	0	mammalian_target_of_rapamycin	98,127	Redd1	132,137	mammalian target of rapamycin	Redd1	2475	54541	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Activating_transcription_factor_4 and CCAAT/enhancer-binding _ protein-beta negatively regulate the mammalian_target_of_rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress .
14982927	0	mammalian_target_of_rapamycin	148,177	Rheb	142,146	mammalian target of rapamycin	Rheb	2475	6009	Gene	Gene	START_ENTITY|amod|hypoxia-inducible_factor-1 hypoxia-inducible_factor-1|nmod|homolog_enriched_in_brain homolog_enriched_in_brain|appos|END_ENTITY	Follicle-stimulating hormone activation of hypoxia-inducible_factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras _ homolog_enriched_in_brain -LRB- Rheb -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway is necessary for induction of select protein markers of follicular differentiation .
15809346	0	mammalian_target_of_rapamycin	107,136	Rheb	31,35	mammalian target of rapamycin	Rheb	2475	6009	Gene	Gene	activation|nmod|START_ENTITY endocytic|nmod|activation implication|nmod|endocytic role|dep|implication role|nmod|END_ENTITY	Novel role of the small GTPase Rheb : its implication in endocytic pathway independent of the activation of mammalian_target_of_rapamycin .
15878852	0	mammalian_target_of_rapamycin	16,45	Rheb	0,4	mammalian target of rapamycin	Rheb	2475	6009	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Rheb binding to mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by amino_acid sufficiency .
16728407	0	mammalian_target_of_rapamycin	19,48	Rheb	102,106	mammalian target of rapamycin	Rheb	2475	6009	Gene	Gene	Hyperactivation|nmod|START_ENTITY Hyperactivation|acl|signaling signaling|nmod|mutant mutant|nmod|GTPase GTPase|compound|END_ENTITY	Hyperactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling by a gain-of-function mutant of the Rheb GTPase .
17928295	0	mammalian_target_of_rapamycin	49,78	Rheb	99,103	mammalian target of rapamycin	Rheb	2475	6009	Gene	Gene	inhibition|nmod|START_ENTITY mediates|dobj|inhibition mediates|advcl|interacting interacting|nmod|END_ENTITY	Bnip3 mediates the hypoxia-induced inhibition on mammalian_target_of_rapamycin by interacting with Rheb .
24648513	0	mammalian_target_of_rapamycin	116,145	Rheb	61,65	mammalian target of rapamycin	Rheb	2475	6009	Gene	Gene	regulator|nmod|START_ENTITY generates|dobj|regulator generates|nsubj|mutation mutation|nmod|glycine glycine|nmod|END_ENTITY	Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
20169165	0	mammalian_target_of_rapamycin	31,60	SIRT1	0,5	mammalian target of rapamycin	SIRT1	2475	23411	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SIRT1 negatively regulates the mammalian_target_of_rapamycin .
17210710	0	mammalian_target_of_rapamycin	154,183	eIF4E	184,189	mammalian target of rapamycin	eIF4E	2475	1977	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Nitric_oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast_cancer cells : involvement of mammalian_target_of_rapamycin / eIF4E pathway .
12242281	0	mammalian_target_of_rapamycin	77,106	hypoxia-inducible_factor_1alpha	14,45	mammalian target of rapamycin	hypoxia-inducible factor 1alpha	2475	3091	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of hypoxia-inducible_factor_1alpha expression and function by the mammalian_target_of_rapamycin .
23786956	0	mammalian_target_of_rapamycin	69,98	hypoxia_inducible_factor_1	99,125	mammalian target of rapamycin	hypoxia inducible factor 1	2475	3091	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Chronic intermittent_hypoxia increases b cell mass and activates the mammalian_target_of_rapamycin / hypoxia_inducible_factor_1 / vascular_endothelial_growth_factor_A pathway in mice pancreatic islet .
26041412	0	mammalian_target_of_rapamycin	4,33	integrin-linked_kinase	120,142	mammalian target of rapamycin	integrin-linked kinase	2475	3611	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	The mammalian_target_of_rapamycin signaling pathway regulates myocyte enhancer factor-2C phosphorylation levels through integrin-linked_kinase in goat skeletal muscle satellite cells .
15522880	0	mammalian_target_of_rapamycin	101,130	interferon-gamma	23,39	mammalian target of rapamycin	interferon-gamma	2475	3458	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian_target_of_rapamycin -LRB- mTOR -RRB- .
10947949	0	mammalian_target_of_rapamycin	174,203	mTOR	205,209	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	L-leucine availability regulates phosphatidylinositol_3-kinase , p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells : evidence for the involvement of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway in the L-leucine-induced up-regulation of system A amino_acid transport .
10972980	0	mammalian_target_of_rapamycin	59,88	mTOR	90,94	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY pathways|nmod|regulation Assessment|nmod|pathways Assessment|appos|END_ENTITY	Assessment of cell-signaling pathways in the regulation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by amino_acids in rat adipocytes .
11942857	0	mammalian_target_of_rapamycin	105,134	mTOR	136,140	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Insulin regulation of hepatic_insulin-like_growth factor-binding protein-1 -LRB- IGFBP-1 -RRB- gene expression and mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling is impaired by the presence of hydrogen_peroxide .
12604610	0	mammalian_target_of_rapamycin	4,33	mTOR	35,39	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	partner|compound|START_ENTITY partner|appos|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
12604610	0	mammalian_target_of_rapamycin	4,33	mTOR	68,72	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	partner|compound|START_ENTITY binds|nsubj|partner binds|ccomp|substrates substrates|nsubj|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
14576155	0	mammalian_target_of_rapamycin	39,68	mTOR	70,74	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	AKT activity determines sensitivity to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors by regulating cyclin_D1 and c-myc expression .
14970221	0	mammalian_target_of_rapamycin	19,48	mTOR	50,54	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Thr2446 is a novel mammalian_target_of_rapamycin -LRB- mTOR -RRB- phosphorylation site regulated by nutrient status .
15459249	0	mammalian_target_of_rapamycin	36,65	mTOR	67,71	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Farnesylthiosalicylic_acid inhibits mammalian_target_of_rapamycin -LRB- mTOR -RRB- activity both in cells and in vitro by promoting dissociation of the mTOR-raptor complex .
15878852	0	mammalian_target_of_rapamycin	16,45	mTOR	47,51	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Rheb binding to mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by amino_acid sufficiency .
15905173	0	mammalian_target_of_rapamycin	41,70	mTOR	72,76	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	S6_kinase_1|nmod|START_ENTITY Identification|nmod|S6_kinase_1 Identification|appos|END_ENTITY	Identification of S6_kinase_1 as a novel mammalian_target_of_rapamycin -LRB- mTOR -RRB- - phosphorylating kinase .
15923340	0	mammalian_target_of_rapamycin	150,179	mTOR	181,185	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	proliferation|nmod|START_ENTITY proliferation|appos|END_ENTITY	LY303511 -LRB- 2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one -RRB- acts via phosphatidylinositol_3-kinase-independent pathways to inhibit cell proliferation via mammalian_target_of_rapamycin -LRB- mTOR -RRB- - and non-mTOR-dependent mechanisms .
16344552	0	mammalian_target_of_rapamycin	41,70	mTOR	72,76	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Glucose-stimulated DNA synthesis through mammalian_target_of_rapamycin -LRB- mTOR -RRB- is regulated by KATP channels : effects on cell cycle progression in rodent islets .
16798736	0	mammalian_target_of_rapamycin	14,43	mTOR	121,125	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY associated|nsubjpass|Activation associated|nmod|stimulation stimulation|nmod|END_ENTITY	Activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1 .
17041621	0	mammalian_target_of_rapamycin	16,45	mTOR	73,77	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	Upstream|nmod|START_ENTITY Upstream|parataxis|pass pass|nmod|END_ENTITY	Upstream of the mammalian_target_of_rapamycin : do all roads pass through mTOR ?
17234578	0	mammalian_target_of_rapamycin	147,176	mTOR	177,181	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	The cationic amino_acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian_target_of_rapamycin mTOR pathway .
18326485	0	mammalian_target_of_rapamycin	49,78	mTOR	80,84	mammalian target of rapamycin	mTOR	56717(Tax:10090)	21977(Tax:10090)	Gene	Gene	mutant|compound|START_ENTITY mutant|compound|END_ENTITY	Cardiac restricted overexpression of kinase-dead mammalian_target_of_rapamycin -LRB- mTOR -RRB- mutant impairs the mTOR-mediated signaling and cardiac function .
18474609	0	mammalian_target_of_rapamycin	124,153	mTOR	155,159	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	fragile_X_mental_retardation_protein|nmod|START_ENTITY fragile_X_mental_retardation_protein|appos|END_ENTITY	S6K1 phosphorylates and regulates fragile_X_mental_retardation_protein -LRB- FMRP -RRB- with the neuronal protein synthesis-dependent mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling cascade .
18495876	0	mammalian_target_of_rapamycin	54,83	mTOR	85,89	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	tuberous_sclerosis|nmod|START_ENTITY inhibitors|amod|tuberous_sclerosis inhibitors|appos|END_ENTITY	Response of a neuronal model of tuberous_sclerosis to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors : effects on mTORC1 and Akt signaling lead to improved survival and function .
19244117	0	mammalian_target_of_rapamycin	33,62	mTOR	110,114	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY marker|nsubj|phosphorylation marker|nmod|END_ENTITY	TORC-specific phosphorylation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- : phospho-Ser2481 is a marker for intact mTOR signaling complex 2 .
19473483	0	mammalian_target_of_rapamycin	64,93	mTOR	95,99	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	RAD001|amod|START_ENTITY RAD001|compound|END_ENTITY	Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor RAD001 strongly inhibits adhesion and growth of renal_cell_carcinoma cells .
19576515	0	mammalian_target_of_rapamycin	43,72	mTOR	74,78	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Glutamate-dependent phosphorylation of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in Bergmann glial cells .
19875810	0	mammalian_target_of_rapamycin	16,45	mTOR	47,51	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in renal_disease .
19916508	0	mammalian_target_of_rapamycin	58,87	mTOR	89,93	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Morpholine derivatives greatly enhance the selectivity of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors .
19920197	0	mammalian_target_of_rapamycin	20,49	mTOR	120,124	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|facilitating facilitating|nmod|axis axis|compound|END_ENTITY	Perifosine inhibits mammalian_target_of_rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy .
20005385	0	mammalian_target_of_rapamycin	28,57	mTOR	59,63	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Immunosuppression using the mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor everolimus : pilot study shows significant cognitive and affective improvement .
20371977	0	mammalian_target_of_rapamycin	29,58	mTOR	60,64	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	autophagy|nmod|START_ENTITY Involvement|nmod|autophagy Involvement|appos|END_ENTITY	Involvement of autophagy via mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in tributyltin-induced neuronal cell death .
20421347	0	mammalian_target_of_rapamycin	44,73	mTOR	75,79	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Inhibition of human T-cell proliferation by mammalian_target_of_rapamycin -LRB- mTOR -RRB- antagonists requires noncoding RNA growth-arrest-specific_transcript_5 -LRB- GAS5 -RRB- .
20484410	0	mammalian_target_of_rapamycin	29,58	mTOR	60,64	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	cAMP-dependent activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- in thyroid cells .
20607654	0	mammalian_target_of_rapamycin	11,40	mTOR	42,46	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	A role for mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway in non alcoholic_steatohepatitis related-cirrhosis .
20797855	0	mammalian_target_of_rapamycin	73,102	mTOR	104,108	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
20860370	0	mammalian_target_of_rapamycin	156,185	mTOR	187,191	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Discovery of 1 - -LRB- 4 - -LRB- 4-propionylpiperazin-1-yl -RRB- -3 - -LRB- trifluoromethyl -RRB- phenyl -RRB- -9 - -LRB- quinolin-3-yl -RRB- benzo -LSB- h -RSB- -LSB- 1,6 -RSB- naphthyridin-2 -LRB- 1H -RRB- - one as a highly potent , selective mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor for the treatment of cancer .
21187044	0	mammalian_target_of_rapamycin	11,40	mTOR	1,5	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- mTOR , the mammalian_target_of_rapamycin -RSB- .
21266573	0	mammalian_target_of_rapamycin	42,71	mTOR	73,77	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Naturally secreted amyloid-beta increases mammalian_target_of_rapamycin -LRB- mTOR -RRB- activity via a PRAS40-mediated mechanism .
21322566	0	mammalian_target_of_rapamycin	156,185	mTOR	187,191	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Discovery of 9 - -LRB- 6-aminopyridin-3-yl -RRB- -1 - -LRB- 3 - -LRB- trifluoromethyl -RRB- phenyl -RRB- benzo -LSB- h -RSB- -LSB- 1,6 -RSB- naphthyridin-2 -LRB- 1H -RRB- - one -LRB- Torin2 -RRB- as a potent , selective , and orally available mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor for treatment of cancer .
21332118	0	mammalian_target_of_rapamycin	89,118	mTOR	120,124	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	START_ENTITY|dobj|inhibitors inhibitors|appos|END_ENTITY	Discovery and optimization of a series of benzothiazole phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors .
21354266	0	mammalian_target_of_rapamycin	20,49	mTOR	51,55	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Therapeutic role of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in preventing epileptogenesis .
21484496	0	mammalian_target_of_rapamycin	21,50	mTOR	52,56	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	directions|nmod|START_ENTITY directions|appos|END_ENTITY	Future directions of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor therapy in renal_cell_carcinoma .
21495671	0	mammalian_target_of_rapamycin	57,86	mTOR	88,92	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|appos|END_ENTITY	Potent , selective , and orally bioavailable inhibitors of mammalian_target_of_rapamycin -LRB- mTOR -RRB- kinase based on a quaternary substituted dihydrofuropyrimidine .
21533544	0	mammalian_target_of_rapamycin	42,71	mTOR	73,77	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY biomarkers|nmod|activity biomarkers|appos|END_ENTITY	Predictive biomarkers for the activity of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors .
21735472	0	mammalian_target_of_rapamycin	58,87	mTOR	89,93	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	signal|amod|START_ENTITY signal|appos|END_ENTITY	Novel feedback inhibition of surface antigen synthesis by mammalian_target_of_rapamycin -LRB- mTOR -RRB- signal and its implication for hepatitis_B virus tumorigenesis and therapy .
21965657	0	mammalian_target_of_rapamycin	10,39	mTOR	71,75	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	mTOR|appos|START_ENTITY maintains|nsubj|mTOR maintains|dobj|integrity integrity|nmod|complex complex|compound|END_ENTITY	The mTOR -LRB- mammalian_target_of_rapamycin -RRB- kinase maintains integrity of mTOR complex 2 .
22040565	0	mammalian_target_of_rapamycin	16,45	mTOR	47,51	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|appos|END_ENTITY	Inactivation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- by rapamycin in a murine model of lipopolysaccharide-induced acute_lung_injury .
22223645	0	mammalian_target_of_rapamycin	53,82	mTOR	84,88	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Kinome-wide selectivity profiling of ATP-competitive mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors and characterization of their binding kinetics .
22337890	0	mammalian_target_of_rapamycin	136,165	mTOR	167,171	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Inhibition of chemokine -LRB- CXC motif -RRB- ligand 12/chemokine -LRB- CXC motif -RRB- receptor 4 axis -LRB- CXCL12/CXCR4 -RRB- - mediated cell migration by targeting mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway in human gastric_carcinoma cells .
22460837	0	mammalian_target_of_rapamycin	102,131	mTOR	133,137	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Comparative efficacy of vascular_endothelial_growth_factor -LRB- VEGF -RRB- tyrosine kinase inhibitor -LRB- TKI -RRB- and mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor as second-line therapy in patients with metastatic_renal_cell_carcinoma after the failure of first-line VEGF TKI .
22492229	0	mammalian_target_of_rapamycin	14,43	mTOR	45,49	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- in glutamate-induced down-regulation of tuberous_sclerosis complex proteins 2 -LRB- TSC2 -RRB- .
22567115	0	mammalian_target_of_rapamycin	102,131	mTOR	133,137	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The interaction between early life epilepsy and autistic-like behavioral consequences : a role for the mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway .
22645144	0	mammalian_target_of_rapamycin	124,153	mTOR	118,122	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	pathway|dep|START_ENTITY pathway|amod|END_ENTITY	Leucine stimulates insulin secretion via down-regulation of surface expression of adrenergic a2A receptor through the mTOR -LRB- mammalian_target_of_rapamycin -RRB- pathway : implication in new-onset diabetes in renal transplantation .
23054937	0	mammalian_target_of_rapamycin	12,41	mTOR	43,47	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition in the treatment of advanced breast_cancer .
23185989	0	mammalian_target_of_rapamycin	23,52	mTOR	17,21	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	The mechanism of mTOR -LRB- mammalian_target_of_rapamycin -RRB- in a mouse model of polycystic_ovary_syndrome -LRB- PCOS -RRB- .
23587222	0	mammalian_target_of_rapamycin	14,43	mTOR	45,49	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- in triple_negative feline mammary_carcinomas .
23662044	0	mammalian_target_of_rapamycin	23,52	mTOR	54,58	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Targeted inhibition of mammalian_target_of_rapamycin -LRB- mTOR -RRB- enhances radiosensitivity in pancreatic_carcinoma cells .
23838481	0	mammalian_target_of_rapamycin	16,45	mTOR	47,51	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Bone effects of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibition with everolimus .
23899586	0	mammalian_target_of_rapamycin	63,92	mTOR	94,98	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	suppression|amod|START_ENTITY suppression|appos|END_ENTITY	Alterations of hypoxia-induced factor signaling pathway due to mammalian_target_of_rapamycin -LRB- mTOR -RRB- suppression in ovarian_clear_cell_adenocarcinoma : in vivo and in vitro explorations for clinical trial .
24559928	0	mammalian_target_of_rapamycin	12,41	mTOR	43,47	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Role of the mammalian_target_of_rapamycin -LRB- mTOR -RRB- complexes in pancreatic b-cell mass regulation .
24790108	0	mammalian_target_of_rapamycin	18,47	mTOR	49,53	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	Mis-regulation of mammalian_target_of_rapamycin -LRB- mTOR -RRB- complexes induced by albuminuria in proximal tubules .
25010764	0	mammalian_target_of_rapamycin	23,52	mTOR	17,21	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	-LSB- Significance of mTOR -LRB- mammalian_target_of_rapamycin -RRB- activity in human lymphomas -RSB- .
25769191	0	mammalian_target_of_rapamycin	35,64	mTOR	66,70	mammalian target of rapamycin	mTOR	2475	21977(Tax:10090)	Gene	Gene	use|nmod|START_ENTITY Advances|nmod|use Advances|appos|END_ENTITY	Advances in the therapeutic use of mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors in dermatology .
18372248	0	mammalian_target_of_rapamycin	72,101	mTORC1	113,119	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Regulation of proline-rich_Akt_substrate_of_40_kDa -LRB- PRAS40 -RRB- function by mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- - mediated phosphorylation .
18495876	0	mammalian_target_of_rapamycin	54,83	mTORC1	114,120	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	tuberous_sclerosis|nmod|START_ENTITY inhibitors|amod|tuberous_sclerosis model|nmod|inhibitors Response|nmod|model Response|dep|effects effects|nmod|END_ENTITY	Response of a neuronal model of tuberous_sclerosis to mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitors : effects on mTORC1 and Akt signaling lead to improved survival and function .
18949455	0	mammalian_target_of_rapamycin	14,43	mTORC1	55,61	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Early loss of mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- signalling and reduction in cell size during dominant-negative suppression of hepatic nuclear factor 1-alpha -LRB- HNF1A -RRB- function in INS-1 insulinoma cells .
19150980	0	mammalian_target_of_rapamycin	19,48	mTORC1	100,106	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY reveals|nsubj|inhibitor reveals|dobj|functions functions|nmod|END_ENTITY	An ATP-competitive mammalian_target_of_rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 .
21757713	0	mammalian_target_of_rapamycin	70,99	mTORC1	111,117	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activation .
21784859	0	mammalian_target_of_rapamycin	16,45	mTORC1	57,63	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Redox regulates mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity by modulating the TSC1/TSC2-Rheb GTPase pathway .
23317821	0	mammalian_target_of_rapamycin	109,138	mTORC1	150,156	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Regulation of blood-testis barrier -LRB- BTB -RRB- dynamics during spermatogenesis via the `` Yin '' and `` Yang '' effects of mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- and mTORC2 .
24990947	0	mammalian_target_of_rapamycin	77,106	mTORC1	28,34	mammalian target of rapamycin	mTORC1	2475	382056(Tax:10090)	Gene	Gene	mTOR|appos|START_ENTITY phosphorylation|nmod|mTOR involves|dobj|phosphorylation involves|nsubj|activation activation|nmod|complex complex|amod|END_ENTITY	Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR -LRB- mammalian_target_of_rapamycin -RRB- by IkB_kinase_a -LRB- IKKa -RRB- .
24187137	0	mammalian_target_of_rapamycin	48,77	myonectin	24,33	mammalian target of rapamycin	myonectin	2475	151176	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Skeletal muscle-derived myonectin activates the mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway to suppress autophagy in liver .
11602639	0	mammalian_target_of_rapamycin	88,117	p53	163,166	mammalian target of rapamycin	p53	2475	7157	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Human_immunodeficiency_virus_1 envelope glycoprotein complex-induced apoptosis involves mammalian_target_of_rapamycin / FKBP12-rapamycin-associated_protein-mediated p53 phosphorylation .
17077083	0	mammalian_target_of_rapamycin	83,112	p70_S6K	113,120	mammalian target of rapamycin	p70 S6K	2475	6198	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian_target_of_rapamycin / p70_S6K pathway .
10567431	0	mammalian_target_of_rapamycin	15,44	p70_S6_kinase_alpha	74,93	mammalian target of rapamycin	p70 S6 kinase alpha	2475	6198	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	Immunopurified mammalian_target_of_rapamycin phosphorylates and activates p70_S6_kinase_alpha in vitro .
15504954	0	mammalian_target_of_rapamycin	75,104	peroxisome_proliferator-activated_receptor-gamma	14,62	mammalian target of rapamycin	peroxisome proliferator-activated receptor-gamma	2475	5468	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|activity activity|amod|END_ENTITY	regulation of peroxisome_proliferator-activated_receptor-gamma activity by mammalian_target_of_rapamycin and amino_acids in adipogenesis .
20797855	0	mammalian_target_of_rapamycin	73,102	phosphatidylinositol-3-kinase	36,65	mammalian target of rapamycin	phosphatidylinositol-3-kinase	2475	5293	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
21062517	0	mammalian_target_of_rapamycin	34,63	phosphatidylinositol_3-kinase	4,33	mammalian target of rapamycin	phosphatidylinositol 3-kinase	2475	5293	Gene	Gene	inhibition|compound|START_ENTITY inhibition|amod|END_ENTITY	Can phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibition ERase them all ?
22452803	0	mammalian_target_of_rapamycin	62,91	phosphatidylinositol_3-kinase	32,61	mammalian target of rapamycin	phosphatidylinositol 3-kinase	2475	5293	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	NVP-BEZ235 and NVP-BGT226 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitors , enhance tumor and endothelial cell radiosensitivity .
23768063	0	mammalian_target_of_rapamycin	47,76	phosphatidylinositol_3-kinase	17,46	mammalian target of rapamycin	phosphatidylinositol 3-kinase	2475	5293	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	NVP-BEZ235 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor , prominently enhances radiosensitivity of prostate_cancer cell line PC-3 .
12773158	0	mammalian_target_of_rapamycin	114,143	phosphoinositide_3-kinase	73,98	mammalian target of rapamycin	phosphoinositide 3-kinase	2475	5293	Gene	Gene	connect|nmod|START_ENTITY connect|dobj|pathway pathway|amod|END_ENTITY	United at last : the tuberous_sclerosis complex gene products connect the phosphoinositide_3-kinase / Akt pathway to mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling .
17971449	0	mammalian_target_of_rapamycin	12,41	phosphoinositide_3-kinase	47,72	mammalian target of rapamycin	phosphoinositide 3-kinase	2475	5293	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Coupling of mammalian_target_of_rapamycin with phosphoinositide_3-kinase signaling pathway regulates protein phosphatase 2A - and glycogen synthase kinase-3 - dependent phosphorylation of Tau .
19372588	0	mammalian_target_of_rapamycin	55,84	phosphoinositide_3-kinase	29,54	mammalian target of rapamycin	phosphoinositide 3-kinase	2475	5293	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Targeting melanoma with dual phosphoinositide_3-kinase / mammalian_target_of_rapamycin inhibitors .
19789349	0	mammalian_target_of_rapamycin	31,60	phosphoinositide_3-kinase	5,30	mammalian target of rapamycin	phosphoinositide 3-kinase	2475	5293	Gene	Gene	blockade|compound|START_ENTITY strategy|nsubj|blockade END_ENTITY|parataxis|strategy	Dual phosphoinositide_3-kinase / mammalian_target_of_rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small_cell_lung_cancer harboring K-RAS mutations .
21714526	0	mammalian_target_of_rapamycin	69,98	phosphoinositide_3-kinase	36,61	mammalian target of rapamycin	phosphoinositide 3-kinase	2475	5293	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships of phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors : investigations of various 6,5-heterocycles to improve metabolic stability .
21854819	0	mammalian_target_of_rapamycin	118,147	phosphoinositide_3-kinase	92,117	mammalian target of rapamycin	phosphoinositide 3-kinase	2475	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Insulin-induced neurite-like process outgrowth : acceleration of tau protein synthesis via a phosphoinositide_3-kinase ~ mammalian_target_of_rapamycin pathway .
23533654	0	mammalian_target_of_rapamycin	31,60	phosphoinositide_3-kinase	5,30	mammalian target of rapamycin	phosphoinositide 3-kinase	2475	5290	Gene	Gene	NVP-BEZ235|amod|START_ENTITY has|nsubj|NVP-BEZ235 END_ENTITY|parataxis|has	Dual phosphoinositide_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal_carcinoma .
15036397	0	mammalian_target_of_rapamycin	67,96	protein_kinase_B	44,60	mammalian target of rapamycin	protein kinase B	2475	2185	Gene	Gene	signaling|nsubj|START_ENTITY Effects|parataxis|signaling Effects|nmod|END_ENTITY	Effects of aerobic exercise training on the protein_kinase_B -LRB- PKB -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling pathway in aged skeletal muscle .
22657251	0	mammalian_target_of_rapamycin	81,110	protein_kinase_B	5,21	mammalian target of rapamycin	protein kinase B	2475	2185	Gene	Gene	mTOR|appos|START_ENTITY downstream|nmod|mTOR isoform|dobj|downstream isoform|nsubj|Akt Akt|appos|END_ENTITY	Akt -LRB- protein_kinase_B -RRB- isoform phosphorylation and signaling downstream of mTOR -LRB- mammalian_target_of_rapamycin -RRB- in denervated atrophic and hypertrophic mouse skeletal muscle .
23920219	0	mammalian_target_of_rapamycin	153,182	protein_kinase_B	134,150	mammalian target of rapamycin	protein kinase B	2475	2185	Gene	Gene	3-kinase|acl|START_ENTITY 3-kinase|appos|Akt Akt|appos|END_ENTITY	Insights into insulin-mediated regulation of CYP2E1 : miR-132 / -212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase , Akt -LRB- protein_kinase_B -RRB- , mammalian_target_of_rapamycin signaling in regulating miR-132 / -212 and miR-122 / -181 a expression in primary cultured rat hepatocytes .
9636226	0	mammalian_target_of_rapamycin	69,98	protein_kinase_B	113,129	mammalian target of rapamycin	protein kinase B	2475	2185	Gene	Gene	phosphorylation|nmod|START_ENTITY Evidence|nmod|phosphorylation mediated|nsubj|Evidence mediated|nmod|END_ENTITY	Evidence of insulin-stimulated phosphorylation and activation of the mammalian_target_of_rapamycin mediated by a protein_kinase_B signaling pathway .
22574221	0	mammalian_target_of_rapamycin	100,129	pyruvate_kinase_M2	63,81	mammalian target of rapamycin	pyruvate kinase M2	2475	5315	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Resveratrol inhibits cancer cell metabolism by down regulating pyruvate_kinase_M2 via inhibition of mammalian_target_of_rapamycin .
12604610	0	mammalian_target_of_rapamycin	4,33	raptor	50,56	mammalian target of rapamycin	raptor	2475	57521	Gene	Gene	partner|compound|START_ENTITY partner|appos|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
14522890	0	mammalian_target_of_rapamycin	130,159	ribosomal_protein_S6_and_4E-BP1	52,83	mammalian target of rapamycin	ribosomal protein S6 and 4E-BP1	2475	6194;1978	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Bcr-Abl kinase modulates the translation regulators ribosomal_protein_S6_and_4E-BP1 in chronic_myelogenous_leukemia cells via the mammalian_target_of_rapamycin .
21471201	0	mammalian_target_of_rapamycin	88,117	sirtuin_1	149,158	mammalian target of rapamycin	sirtuin 1	2475	23411	Gene	Gene	START_ENTITY|dep|Inhibition Inhibition|nmod|END_ENTITY	Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian_target_of_rapamycin -LRB- mTOR -RRB- - dependent Inhibition of sirtuin_1 .
23786956	0	mammalian_target_of_rapamycin	69,98	vascular_endothelial_growth_factor_A	126,162	mammalian target of rapamycin	vascular endothelial growth factor A	2475	7422	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Chronic intermittent_hypoxia increases b cell mass and activates the mammalian_target_of_rapamycin / hypoxia_inducible_factor_1 / vascular_endothelial_growth_factor_A pathway in mice pancreatic islet .
11861906	0	mammalian_translation_initiation_factor_5	19,60	eIF5	62,66	mammalian translation initiation factor 5	eIF5	1983	1983	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of mammalian_translation_initiation_factor_5 -LRB- eIF5 -RRB- in vitro and in vivo .
2494062	0	mammary-derived_growth_inhibitor	12,44	c-fos	80,85	mammary-derived growth inhibitor	c-fos	2170	2353	Gene	Gene	Effect|nmod|START_ENTITY Effect|amod|END_ENTITY	Effect of a mammary-derived_growth_inhibitor on the expression of the oncogenes c-fos , c-myc and c-ras .
11252168	0	mammary_cancer_susceptibility_1	44,75	Mcs1	77,81	mammary cancer susceptibility 1	Mcs1	326383(Tax:10116)	326383(Tax:10116)	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Analysis of candidate genes included in the mammary_cancer_susceptibility_1 -LRB- Mcs1 -RRB- region .
2091050	0	mammary_derived_growth_inhibitor	56,88	MDGI	90,94	mammary derived growth inhibitor	MDGI	281758(Tax:9913)	281758(Tax:9913)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Characterization and function dependent localization of mammary_derived_growth_inhibitor -LRB- MDGI -RRB- in mammary glands of bovine and mice .
18439947	0	mammary_serine_protease_inhibitor	24,57	MASPIN	59,65	mammary serine protease inhibitor	MASPIN	5268	5268	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Nuclear localization of mammary_serine_protease_inhibitor -LRB- MASPIN -RRB- : is its impact on the prognosis in laryngeal_carcinoma due to a proapoptotic effect ?
18554282	0	mandibuloacral_dysplasia_type_A	78,109	matrix_metalloproteinase-9	34,60	mandibuloacral dysplasia type A	matrix metalloproteinase-9	270	4318	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Increased release and activity of matrix_metalloproteinase-9 in patients with mandibuloacral_dysplasia_type_A , a rare premature_ageing_syndrome .
21671088	0	manganese-containing_superoxide_dismutase	20,61	MnSOD	63,68	manganese-containing superoxide dismutase	MnSOD	6648	6648	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Manganese regulates manganese-containing_superoxide_dismutase -LRB- MnSOD -RRB- expression in the primary broiler_myocardial_cells .
11641265	0	manganese-superoxide_dismutase	43,73	Vascular_endothelial_growth_factor	0,34	manganese-superoxide dismutase	Vascular endothelial growth factor	6648	7422	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces manganese-superoxide_dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism .
20188165	0	manganese-superoxide_dismutase	53,83	hypoxia-inducible_factor-1alpha	96,127	manganese-superoxide dismutase	hypoxia-inducible factor-1alpha	6648	3091	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Reactive oxygen species produced by the knockdown of manganese-superoxide_dismutase up-regulate hypoxia-inducible_factor-1alpha expression in oral_squamous_cell_carcinoma cells .
12354745	0	manganese_superoxide_dismutase	31,61	Heat_shock_protein_72	0,21	manganese superoxide dismutase	Heat shock protein 72	6648	3303	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Heat_shock_protein_72 enhances manganese_superoxide_dismutase activity during myocardial_ischemia-reperfusion_injury , associated with mitochondrial protection and apoptosis reduction .
27055786	0	manganese_superoxide_dismutase	20,50	MnSOD	52,57	manganese superoxide dismutase	MnSOD	6648	6648	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between manganese_superoxide_dismutase -LRB- MnSOD -RRB- polymorphism and prostate_cancer susceptibility : a meta-analysis .
9199894	0	manganese_superoxide_dismutase	30,60	SOD2	62,66	manganese superoxide dismutase	SOD2	6648	6648	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Transcriptional inhibition of manganese_superoxide_dismutase -LRB- SOD2 -RRB- gene expression by DNA methylation of the 5 ' CpG island .
21054788	0	mannan-binding_lectin	20,41	CD91	0,4	mannan-binding lectin	CD91	4153	4035	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD91 interacts with mannan-binding_lectin -LRB- MBL -RRB- through the MBL-associated serine protease-binding site .
25203057	0	mannan-binding_lectin	12,33	H-ficolin	43,52	mannan-binding lectin	H-ficolin	4153	8547	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Circulating mannan-binding_lectin , M - , L - , H-ficolin and collectin-liver-1 levels in patients with acute_liver_failure .
17045845	0	mannan-binding_lectin	4,25	MASP-2	138,144	mannan-binding lectin	MASP-2	4153	10747	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The mannan-binding_lectin pathway and lung_disease in cystic_fibrosis -- disfunction of mannan-binding_lectin-associated serine protease 2 -LRB- MASP-2 -RRB- may be a major modifier .
15117939	0	mannan-binding_lectin	111,132	MAp19	74,79	mannan-binding lectin	MAp19	4153	10747	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The X-ray structure of human mannan-binding_lectin-associated_protein_19 -LRB- MAp19 -RRB- and its interaction site with mannan-binding_lectin and L-ficolin .
10022380	0	mannan-binding_lectin	45,66	MBL	68,71	mannan-binding lectin	MBL	4153	4153	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	High-level and effective production of human mannan-binding_lectin -LRB- MBL -RRB- in Chinese_hamster_ovary -LRB- CHO -RRB- cells .
10915847	0	mannan-binding_lectin	73,94	MBL	96,99	mannan-binding lectin	MBL	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of structural gene mutations and promoter polymorphisms in the mannan-binding_lectin -LRB- MBL -RRB- gene by polymerase chain reaction with sequence-specific primers .
16487239	0	mannan-binding_lectin	19,40	MBL	54,57	mannan-binding lectin	MBL	4153	4153	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Elevated levels of mannan-binding_lectin -LSB- corrected -RSB- -LRB- MBL -RRB- and eosinophilia in patients of bronchial_asthma with allergic_rhinitis and allergic_bronchopulmonary_aspergillosis associate with a novel intronic polymorphism in MBL .
17177967	0	mannan-binding_lectin	100,121	MBL-associated_serine_protease_1	128,160	mannan-binding lectin	MBL-associated serine protease 1	4153	5648	Gene	Gene	START_ENTITY|dep|complex complex|dep|END_ENTITY	Severe fibrosis in hepatitis_C_virus-infected patients is associated with increased activity of the mannan-binding_lectin -LRB- MBL -RRB- / MBL-associated_serine_protease_1 -LRB- MASP-1 -RRB- complex .
19416237	0	mannan-binding_lectin	67,88	MBL2	90,94	mannan-binding lectin	MBL2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of genetic association of promoter and structural variants of mannan-binding_lectin -LRB- MBL2 -RRB- gene with susceptibility to generalized vitiligo .
9720214	0	mannan-binding_protein	36,58	MBP	60,63	mannan-binding protein	MBP	4155	4155	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of truncated human mannan-binding_protein -LRB- MBP -RRB- expressed in Escherichia_coli .
12472676	0	mannose-binding_lectin	37,59	MBL	61,64	mannose-binding lectin	MBL	4153	4153	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Analysis of the relationship between mannose-binding_lectin -LRB- MBL -RRB- genotype , MBL levels and function in an Australian blood donor population .
12472676	0	mannose-binding_lectin	37,59	MBL	76,79	mannose-binding lectin	MBL	4153	4153	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Analysis of the relationship between mannose-binding_lectin -LRB- MBL -RRB- genotype , MBL levels and function in an Australian blood donor population .
16517152	0	mannose-binding_lectin	12,34	MBL	36,39	mannose-binding lectin	MBL	4153	4153	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of mannose-binding_lectin -LRB- MBL -RRB- in paediatric oncology patients with febrile_neutropenia .
17711490	0	mannose-binding_lectin	4,26	MBL	28,31	mannose-binding lectin	MBL	4153	4153	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Low mannose-binding_lectin -LRB- MBL -RRB- levels in neonates with pneumonia and sepsis .
21333363	0	mannose-binding_lectin	17,39	MBL	41,44	mannose-binding lectin	MBL	100302094(Tax:9940)	100302094(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in mannose-binding_lectin -LRB- MBL -RRB- gene and their association with MBL protein levels in serum in the Hu sheep .
21681178	0	mannose-binding_lectin	6,28	MBL	30,33	mannose-binding lectin	MBL	4153	4153	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Serum mannose-binding_lectin -LRB- MBL -RRB- gene polymorphism and low MBL levels are associated with neonatal_sepsis and pneumonia .
24134411	0	mannose-binding_lectin	20,42	MBL	44,47	mannose-binding lectin	MBL	4153	4153	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of mannose-binding_lectin -LRB- MBL -RRB- variants by allele-specific sequencing of MBL2 and determination of serum MBL protein levels .
25105751	0	mannose-binding_lectin	4,26	MBL	28,31	mannose-binding lectin	MBL	4153	4153	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Low mannose-binding_lectin -LRB- MBL -RRB- levels and MBL genetic polymorphisms associated with the risk of neonatal_sepsis : An updated meta-analysis .
26188838	0	mannose-binding_lectin	21,43	MBL	45,48	mannose-binding lectin	MBL	4153	4153	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of human mannose-binding_lectin -LRB- MBL -RRB- with Yersinia_enterocolitica lipopolysaccharide .
15306844	0	mannose-binding_lectin	25,47	MBL2	49,53	mannose-binding lectin	MBL2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence analysis of the mannose-binding_lectin -LRB- MBL2 -RRB- gene reveals a high degree of heterozygosity with evidence of selection .
18637753	0	mannose-binding_lectin	23,45	MBL2	47,51	mannose-binding lectin	MBL2	4153	4153	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Detrimental effects of mannose-binding_lectin -LRB- MBL2 -RRB- promoter genotype XA/XA on HIV-1 vertical transmission and AIDS progression .
22131319	0	mannose-binding_lectin	48,70	MBL2	77,81	mannose-binding lectin	MBL2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Study of the effect of DNA polymorphisms in the mannose-binding_lectin gene -LRB- MBL2 -RRB- on disease severity in Slovak cystic_fibrosis patients .
25725598	0	mannose-binding_lectin	40,62	MBL2	69,73	mannose-binding lectin	MBL2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The presence of variant genotype of the mannose-binding_lectin gene -LRB- MBL2 -RRB- is not associated with increased restenosis rate in carotid surgery .
16112196	0	mannose-binding_lectin	41,63	mbl2	70,74	mannose-binding lectin	mbl2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Extra-hepatic transcription of the human mannose-binding_lectin gene -LRB- mbl2 -RRB- and the MBL-associated serine protease 1-3 genes .
21274526	0	mannose-binding_lectin_1	40,64	MBL1	66,70	mannose-binding lectin 1	MBL1	492276(Tax:9823)	492276(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural gene variants in the porcine mannose-binding_lectin_1 -LRB- MBL1 -RRB- gene are associated with low serum MBL-A concentrations .
17380431	0	mannose-binding_lectin_2	52,76	MBL2	78,82	mannose-binding lectin 2	MBL2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between genetic variants in the mannose-binding_lectin_2 -LRB- MBL2 -RRB- gene and HPV_infection .
20712490	0	mannose-binding_lectin_2	41,65	MBL2	67,71	mannose-binding lectin 2	MBL2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High frequency of variant alleles of the mannose-binding_lectin_2 -LRB- MBL2 -RRB- gene are associated with patients infected by hepatitis_B_virus .
24579967	0	mannose-binding_lectin_2	15,39	mbl2	41,45	mannose-binding lectin 2	mbl2	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of mannose-binding_lectin_2 -LRB- mbl2 -RRB- gene heterogeneity and its serum concentration with osteoporosis in postmenopausal women .
8125525	0	mannose-binding_protein	27,50	MBP	52,55	mannose-binding protein	MBP	4155	4155	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Perinatal changes in serum mannose-binding_protein -LRB- MBP -RRB- levels .
14994386	0	mannose_binding_lectin	21,43	MBL	45,48	mannose binding lectin	MBL	4153	4153	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the mannose_binding_lectin -LRB- MBL -RRB- gene are not associated with radiographic erosions in rheumatoid or inflammatory_polyarthritis .
16040048	0	mannose_binding_lectin	74,96	MBL-2	98,103	mannose binding lectin	MBL-2	4153	4153	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	PCR-RFLP genotyping for exon 1 and promoter region mutations of the human mannose_binding_lectin -LRB- MBL-2 -RRB- gene .
22007481	0	mannose_binding_lectin	14,36	TGF-beta1	54,63	mannose binding lectin	TGF-beta1	4153	7040	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Influence of mannose_binding_lectin to expression of TGF-beta1 and NF-kappaB in high concentration of glucose cultured human renal glomerular endothelial cells -RSB- .
17567900	0	mannose_binding_lectin	61,83	surfactant_protein_D	29,49	mannose binding lectin	surfactant protein D	4153	6441	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	AIDS patients have increased surfactant_protein_D but normal mannose_binding_lectin levels in lung fluid .
20598227	0	map2	55,59	P19	85,88	map2	P19	17756(Tax:10090)	83430(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Role of acetylated p53 in regulating the expression of map2 in retinoic_acid-induced P19 cells .
17562265	0	maspin	36,42	hTERT	16,21	maspin	hTERT	5268	7015	Gene	Gene	expression|compound|START_ENTITY expression|nmod|expression expression|amod|END_ENTITY	-LSB- Correlation of hTERT expression to maspin and bFGF expression and their significance in glioma -RSB- .
16982778	0	maspin	68,74	histone_deacetylase_1	25,46	maspin	histone deacetylase 1	5268	3065	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Endogenous inhibition of histone_deacetylase_1 by tumor-suppressive maspin .
10692390	0	maspin	58,64	p53	0,3	maspin	p53	5268	7157	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p53 regulates the expression of the tumor suppressor gene maspin .
12184537	0	maspin	14,20	p53	61,64	maspin	p53	5268	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|relationship relationship|nmod|expression expression|compound|END_ENTITY	Expression of maspin in colon_cancers : its relationship with p53 expression and microvessel density .
15492782	0	maspin	8,14	p53	99,102	maspin	p53	5268	7157	Gene	Gene	expression|compound|START_ENTITY Loss|nmod|expression associated|nsubjpass|Loss associated|nmod|abnormality abnormality|compound|END_ENTITY	Loss of maspin expression is associated with development and progression of gastric_carcinoma with p53 abnormality .
15578720	0	maspin	64,70	p53	30,33	maspin	p53	5268	7157	Gene	Gene	suppressor|compound|START_ENTITY expression|nmod|suppressor inducing|dobj|expression substitute|advcl|inducing substitute|nmod|END_ENTITY	TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor .
17204482	0	maspin	129,135	p53	15,18	maspin	p53	5268	7157	Gene	Gene	Convergence|acl|START_ENTITY Convergence|nmod|END_ENTITY	Convergence of p53 and transforming_growth_factor_beta -LRB- TGFbeta -RRB- signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells .
16137990	0	mass1	51,56	mgr1	45,49	mass1	mgr1	110789(Tax:10090)	110789(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Auditory deficits associated with the frings mgr1 -LRB- mass1 -RRB- mutation in mice .
1634775	0	mast_cell_antigen_AD1	8,29	CD63	50,54	mast cell antigen AD1	CD63	29186(Tax:10116)	967	Gene	Gene	START_ENTITY|dep|homologue homologue|nmod|END_ENTITY	The rat mast_cell_antigen_AD1 -LRB- homologue to human CD63 or melanoma antigen ME491 -RRB- is expressed in other cells in culture .
7514283	0	mast_cell_growth_factor	85,108	MGF	110,113	mast cell growth factor	MGF	4254	4254	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Protein kinase C-dependent release of a functional whole extracellular domain of the mast_cell_growth_factor -LRB- MGF -RRB- receptor by MGF-dependent human myeloid cells .
6788848	2	mast_cell_growth_factor	71,94	TCGF	121,125	mast cell growth factor	TCGF	16187(Tax:10090)	16183(Tax:10090)	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification of a mast_cell_growth_factor and its dissociation from TCGF .
7514200	0	mast_cell_growth_factor	27,50	c-kit	61,66	mast cell growth factor	c-kit	16187(Tax:10090)	16590(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|appos|END_ENTITY	Differential expression of mast_cell_growth_factor receptor -LRB- c-kit -RRB- by peritoneal connective tissue-type mast cells and tissue culture-derived mast cells .
1638026	0	mast_cell_growth_factor	10,33	c-kit_ligand	35,47	mast cell growth factor	c-kit ligand	4254	4254	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of mast_cell_growth_factor -LRB- c-kit_ligand -RRB- on clonogenic leukemic precursor cells .
8112428	0	mast_cell_growth_factor	63,86	granulocyte-macrophage_colony-stimulating_factor	111,159	mast cell growth factor	granulocyte-macrophage colony-stimulating factor	3562	1437	Gene	Gene	marrow|nmod|START_ENTITY marrow|nmod|END_ENTITY	In vitro response of normal and aplastic_anemia bone marrow to mast_cell_growth_factor and in combination with granulocyte-macrophage_colony-stimulating_factor and interleukin-3 .
7516895	0	mast_cell_protease_1	18,38	vitronectin	42,53	mast cell protease 1	vitronectin	29265(Tax:10116)	29169(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of rat mast_cell_protease_1 by vitronectin .
25667044	0	mast_cell_protease_4	82,102	Chymase	0,7	mast cell protease 4	Chymase	17227(Tax:10090)	1215	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Chymase inhibitor-sensitive synthesis of endothelin-1 _ -LRB- 1-31 -RRB- by recombinant mouse mast_cell_protease_4 and human chymase .
12900518	1	mast_cell_protease_4	137,157	thrombin	161,169	mast cell protease 4	thrombin	17227(Tax:10090)	14061(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|amod|END_ENTITY	A role for mouse mast_cell_protease_4 in thrombin regulation and fibronectin turnover .
14616317	0	mast_cell_tryptase	14,32	IgE	43,46	mast cell tryptase	IgE	25823	3497	Gene	Gene	antibodies|compound|START_ENTITY antibodies|compound|END_ENTITY	Screening for mast_cell_tryptase and serum IgE antibodies in 18 patients with anaphylactic shock during general anaesthesia .
24177377	0	mast_cell_tryptase	49,67	eosinophil_cationic_protein	6,33	mast cell tryptase	eosinophil cationic protein	25823	6037	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	Serum eosinophil_cationic_protein is superior to mast_cell_tryptase as marker for response to topical corticosteroid therapy in eosinophilic_esophagitis .
6339626	0	mast_cell_tryptase	63,81	high_molecular_weight_kininogen	22,53	mast cell tryptase	high molecular weight kininogen	25823	3827	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of human high_molecular_weight_kininogen by human mast_cell_tryptase .
10334872	0	mast_cell_tryptase	66,84	myeloperoxidase	11,26	mast cell tryptase	myeloperoxidase	25823	4353	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Neutrophil myeloperoxidase is a potent and selective inhibitor of mast_cell_tryptase .
8144524	0	mast_cell_tryptase	6,24	urinary-type_plasminogen_activator	48,82	mast cell tryptase	urinary-type plasminogen activator	25823	5328	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Human mast_cell_tryptase activates single-chain urinary-type_plasminogen_activator -LRB- pro-urokinase -RRB- .
15019995	0	mastermind-like_1	54,71	Maml1	73,78	mastermind-like 1	Maml1	103806(Tax:10090)	103806(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and functional characterization of the murine mastermind-like_1 -LRB- Maml1 -RRB- gene .
19332510	0	mate1	60,65	multidrug_and_toxin_extrusion_1	27,58	mate1	multidrug and toxin extrusion 1	67473(Tax:10090)	67473(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Targeted disruption of the multidrug_and_toxin_extrusion_1 -LRB- mate1 -RRB- gene in mice reduces renal secretion of metformin .
25365263	0	maternal_embryonic_leucine-zipper_kinase	24,64	MELK	66,70	maternal embryonic leucine-zipper kinase	MELK	9833	9833	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Preclinical efficacy of maternal_embryonic_leucine-zipper_kinase -LRB- MELK -RRB- inhibition in acute_myeloid_leukemia .
17176459	0	matrilin-1	30,40	MATN1	47,52	matrilin-1	MATN1	17180(Tax:10090)	17180(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence of a linkage between matrilin-1 gene -LRB- MATN1 -RRB- and idiopathic_scoliosis .
11852232	0	matrilin-2	72,82	Matn2	51,56	matrilin-2	Matn2	4147	4147	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Comparative analysis of the mouse and human genes -LRB- Matn2 and MATN2 -RRB- for matrilin-2 , a filament-forming protein widely distributed in extracellular matrices .
10656920	0	matrilin-3	35,45	Matn3	52,57	matrilin-3	Matn3	17182(Tax:10090)	17182(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and mapping of the mouse matrilin-3 gene -LRB- Matn3 -RRB- , a member of a gene family containing a U12-type AT-AC intron .
23523902	0	matrilin-3	4,14	VWA1	15,19	matrilin-3	VWA1	4148	64856	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	The matrilin-3 VWA1 domain modulates interleukin-6 release from primary human chondrocytes .
15333466	0	matrilysin-2	15,27	MMP-26	29,35	matrilysin-2	MMP-26	56547	56547	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Association of matrilysin-2 -LRB- MMP-26 -RRB- expression with tumor progression and activation of MMP-9 in esophageal_squamous_cell_carcinoma .
15333466	0	matrilysin-2	15,27	MMP-9	89,94	matrilysin-2	MMP-9	56547	4318	Gene	Gene	expression|amod|START_ENTITY Association|nmod|expression Association|nmod|END_ENTITY	Association of matrilysin-2 -LRB- MMP-26 -RRB- expression with tumor progression and activation of MMP-9 in esophageal_squamous_cell_carcinoma .
18048349	0	matriptase	119,129	hepatocyte_growth_factor_activator_inhibitor_type_1	46,97	matriptase	hepatocyte growth factor activator inhibitor type 1	114093(Tax:10116)	311331(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Roles of functional and structural domains of hepatocyte_growth_factor_activator_inhibitor_type_1 in the inhibition of matriptase .
19907145	0	matriptase-2	8,20	TMPRSS6	22,29	matriptase-2	TMPRSS6	164656	164656	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of matriptase-2 -LRB- TMPRSS6 -RRB- in iron metabolism .
9131273	0	matrix-metalloproteinase-9	40,66	MMP-9	68,73	matrix-metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Sequential production and activation of matrix-metalloproteinase-9 -LRB- MMP-9 -RRB- with breast_cancer progression .
24228496	0	matrix_Gla-protein	13,31	MGP	33,36	matrix Gla-protein	MGP	4256	4256	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	-LSB- Analysis of matrix_Gla-protein -LRB- MGP -RRB- G-7A polymorphism association with ischemic atherothrombotic_stroke in persons with risk factors -RSB- .
1757478	0	matrix_Gla_protein	60,78	MGP	80,83	matrix Gla protein	MGP	25333(Tax:10116)	25333(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Developmental expression and hormonal regulation of the rat matrix_Gla_protein -LRB- MGP -RRB- gene in chondrogenesis and osteogenesis .
8319825	0	matrix_Gla_protein	27,45	MGP	47,50	matrix Gla protein	MGP	4256	4256	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of matrix_Gla_protein -LRB- MGP -RRB- gene expression by retinoic_acid and estrogen in human breast_carcinoma cells .
9738924	0	matrix_Gla_protein	14,32	MGP	34,37	matrix Gla protein	MGP	282660(Tax:9913)	282660(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of matrix_Gla_protein -LRB- MGP -RRB- in an in vitro model of vascular_calcification .
19661459	0	matrix_Gla_protein	90,108	bone_morphogenetic_protein-4	40,68	matrix Gla protein	bone morphogenetic protein-4	17313(Tax:10090)	12159(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|dep|END_ENTITY	Heat_shock protein 70 enhances vascular bone_morphogenetic_protein-4 signaling by binding matrix_Gla_protein .
19306294	0	matrix_gla_protein	44,62	MGP	64,67	matrix gla protein	MGP	17313(Tax:10090)	17313(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sp proteins and Runx2 mediate regulation of matrix_gla_protein -LRB- MGP -RRB- expression by parathyroid_hormone .
25196492	0	matrix_gla_protein	45,63	fibroblast_growth_factor-23	16,43	matrix gla protein	fibroblast growth factor-23	4256	8074	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of serum fibroblast_growth_factor-23 , matrix_gla_protein and fetuin-a in predicting osteoporosis in maintenance_hemodialysis patients .
19306294	0	matrix_gla_protein	44,62	parathyroid_hormone	83,102	matrix gla protein	parathyroid hormone	17313(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Sp proteins and Runx2 mediate regulation of matrix_gla_protein -LRB- MGP -RRB- expression by parathyroid_hormone .
24829764	0	matrix_metallopeptidase-9	74,99	vascular_endothelial_growth_factor	38,72	matrix metallopeptidase-9	vascular endothelial growth factor	4318	7422	Gene	Gene	expressions|amod|START_ENTITY expressions|nmod|END_ENTITY	A multicenter study on expressions of vascular_endothelial_growth_factor , matrix_metallopeptidase-9 and tissue_inhibitor_of_metalloproteinase-2 in oral and maxillofacial_squamous_cell_carcinoma .
24658133	0	matrix_metallopeptidase_13	50,76	p63	0,3	matrix metallopeptidase 13	p63	4322	8626	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p63 transcriptionally regulates the expression of matrix_metallopeptidase_13 .
22820188	0	matrix_metallopeptidase_9	81,106	MMP-9	108,113	matrix metallopeptidase 9	MMP-9	4318	4318	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TNF-a promotes human retinal pigment epithelial -LRB- RPE -RRB- cell migration by inducing matrix_metallopeptidase_9 -LRB- MMP-9 -RRB- expression through activation of Akt/mTORC1 signaling .
23326131	0	matrix_metallopeptidase_9	17,42	Notch2	0,6	matrix metallopeptidase 9	Notch2	4318	4853	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Notch2 regulates matrix_metallopeptidase_9 via PI3K/AKT signaling in human gastric_carcinoma cell MKN-45 .
12861074	0	matrix_metalloprotease-2	71,95	Angiopoietin-2	0,14	matrix metalloprotease-2	Angiopoietin-2	4313	285	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Angiopoietin-2 induces human glioma invasion through the activation of matrix_metalloprotease-2 .
24985902	0	matrix_metalloprotease-3	24,48	MMP-3	50,55	matrix metalloprotease-3	MMP-3	171045(Tax:10116)	171045(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Temporary inductions of matrix_metalloprotease-3 -LRB- MMP-3 -RRB- expression and cell apoptosis are associated with tendon_degeneration or rupture after corticosteroid injection .
9325178	0	matrix_metalloprotease-9	29,53	MMP-9	55,60	matrix metalloprotease-9	MMP-9	4318	4318	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and activation of matrix_metalloprotease-9 -LRB- MMP-9 -RRB- by HL-60 promyelocytic_leukemia cells .
22645147	0	matrix_metalloprotease_7	88,112	MMP7	114,118	matrix metalloprotease 7	MMP7	4316	4316	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The forkhead box transcription factor FOXC1 promotes breast_cancer invasion by inducing matrix_metalloprotease_7 -LRB- MMP7 -RRB- expression .
19577645	0	matrix_metalloproteinase	75,99	MMP-1	101,106	matrix metalloproteinase	MMP-1	4312	4312	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Site controlled transgenic_mice validating increased expression from human matrix_metalloproteinase -LRB- MMP-1 -RRB- promoter due to a naturally occurring SNP .
11005153	0	matrix_metalloproteinase	9,33	MMP-8	35,40	matrix metalloproteinase	MMP-8	4317	4317	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Salivary matrix_metalloproteinase -LRB- MMP-8 -RRB- levels and gelatinase -LRB- MMP-9 -RRB- activities in patients with type_2_diabetes_mellitus .
24192303	0	matrix_metalloproteinase	20,44	MMP2	46,50	matrix metalloproteinase	MMP2	4313	4313	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variants of matrix_metalloproteinase -LRB- MMP2 -RRB- gene influence metabolic_syndrome susceptibility .
19723873	0	matrix_metalloproteinase-1	46,72	CCAAT_enhancer_binding_protein-beta	0,35	matrix metalloproteinase-1	CCAAT enhancer binding protein-beta	4312	1051	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CCAAT_enhancer_binding_protein-beta regulates matrix_metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung_carcinoma cells .
23935888	0	matrix_metalloproteinase-1	24,50	Cardiotrophin-1	0,15	matrix metalloproteinase-1	Cardiotrophin-1	4312	1489	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Cardiotrophin-1 induces matrix_metalloproteinase-1 in human aortic endothelial cells .
16510585	0	matrix_metalloproteinase-1	43,69	Cyr61	14,19	matrix metalloproteinase-1	Cyr61	4312	3491	Gene	Gene	production|amod|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	Tumor-derived Cyr61 -LRB- CCN1 -RRB- promotes stromal matrix_metalloproteinase-1 production and protease-activated_receptor_1-dependent migration of breast_cancer cells .
18588890	0	matrix_metalloproteinase-1	42,68	Hypoxia-inducible_factor-1alpha	0,31	matrix metalloproteinase-1	Hypoxia-inducible factor-1alpha	4312	3091	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor-1alpha regulates matrix_metalloproteinase-1 activity in human bone marrow-derived mesenchymal stem cells .
11039223	0	matrix_metalloproteinase-1	4,30	MMP-1	32,37	matrix metalloproteinase-1	MMP-1	4312	4312	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression in the human endometrium is inversely regulated by interleukin-1_alpha and sex steroids .
11741975	0	matrix_metalloproteinase-1	40,66	MMP-1	68,73	matrix metalloproteinase-1	MMP-1	4312	4312	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	A single nucleotide polymorphism in the matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- promoter influences amnion cell MMP-1 expression and risk for preterm premature_rupture of the fetal membranes .
18571622	0	matrix_metalloproteinase-1	16,42	MMP-1	44,49	matrix metalloproteinase-1	MMP-1	4312	4312	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression in oral_carcinomas of betel quid -LRB- BQ -RRB- users : roles of BQ ingredients in the acceleration of tumour cell motility through MMP-1 .
18705799	0	matrix_metalloproteinase-1	54,80	MMP-1	82,87	matrix metalloproteinase-1	MMP-1	4312	4312	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	The effect of a single nucleotide polymorphism in the matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- promoter on force-induced MMP-1 expression in human periodontal ligament cells .
21359852	0	matrix_metalloproteinase-1	32,58	MMP-1	60,65	matrix metalloproteinase-1	MMP-1	4312	4312	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epidermal growth factor induces matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression and invasion in glioma cell lines via the MAPK pathway .
21730072	0	matrix_metalloproteinase-1	52,78	MMP-1	80,85	matrix metalloproteinase-1	MMP-1	17386(Tax:10090)	17386(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TLR4 protein contributes to cigarette smoke-induced matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- expression in chronic_obstructive_pulmonary_disease .
24587395	0	matrix_metalloproteinase-1	38,64	MMP-1	66,71	matrix metalloproteinase-1	MMP-1	4312	4312	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Extra-cellular matrix proteins induce matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- activity and increase airway smooth muscle contraction in asthma .
10843667	0	matrix_metalloproteinase-1	77,103	Monocyte_chemoattractant_protein-1	0,34	matrix metalloproteinase-1	Monocyte chemoattractant protein-1	4312	6347	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Monocyte_chemoattractant_protein-1 enhances gene expression and synthesis of matrix_metalloproteinase-1 in human fibroblasts by an autocrine IL-1_alpha loop .
10206959	0	matrix_metalloproteinase-1	25,51	p53	0,3	matrix metalloproteinase-1	p53	4312	7157	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	p53 down-regulates human matrix_metalloproteinase-1 -LRB- Collagenase-1 -RRB- gene expression .
24853614	0	matrix_metalloproteinase-1	93,119	type-I_procollagen	57,75	matrix metalloproteinase-1	type-I procollagen	4312	1278	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	CopA3 peptide prevents ultraviolet-induced inhibition of type-I_procollagen and induction of matrix_metalloproteinase-1 in human skin fibroblasts .
22492089	0	matrix_metalloproteinase-10	62,89	thrombin	22,30	matrix metalloproteinase-10	thrombin	4319	2147	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Synergistic effect of thrombin and CD40_ligand on endothelial matrix_metalloproteinase-10 expression and microparticle generation in vitro and in vivo .
16165118	0	matrix_metalloproteinase-11	29,56	stromelysin-3	14,27	matrix metalloproteinase-11	stromelysin-3	17385(Tax:10090)	17385(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of stromelysin-3 -LRB- matrix_metalloproteinase-11 -RRB- in macrophages of murine thymus following thymocyte apoptosis .
20066556	0	matrix_metalloproteinase-12	12,39	S-1	51,54	Matrix metalloproteinase-12	S-1	17381(Tax:10090)	13628(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effect of a matrix_metalloproteinase-12 inhibitor , S-1 , on allergic airway_disease phenotypes in mice .
15802269	0	matrix_metalloproteinase-12	20,47	Wnt-7a	0,6	matrix metalloproteinase-12	Wnt-7a	4321	7476	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Wnt-7a up-regulates matrix_metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing .
22509390	0	matrix_metalloproteinase-12	90,117	progranulin	14,25	matrix metalloproteinase-12	progranulin	4321	2896	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix_metalloproteinase-12 -LRB- MMP-12 -RRB- .
22509390	0	matrix_metalloproteinase-12	90,117	progranulin	75,86	matrix metalloproteinase-12	progranulin	4321	2896	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix_metalloproteinase-12 -LRB- MMP-12 -RRB- .
16368650	0	matrix_metalloproteinase-12	58,85	tumor_necrosis_factor-alpha	29,56	matrix metalloproteinase-12	tumor necrosis factor-alpha	17381(Tax:10090)	21926(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Immunohistochemical study of tumor_necrosis_factor-alpha , matrix_metalloproteinase-12 , and tissue_inhibitor_of_metalloproteinase-2 on alveolar macrophages of BALB/c mice exposed to short-term cigarette smoke .
19415460	0	matrix_metalloproteinase-13	75,102	Discoidin_domain_receptor_2	0,27	matrix metalloproteinase-13	Discoidin domain receptor 2	4322	4921	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	Discoidin_domain_receptor_2 is associated with the increased expression of matrix_metalloproteinase-13 in synovial fibroblasts of rheumatoid_arthritis .
20097749	0	matrix_metalloproteinase-13	16,43	HDAC4	0,5	matrix metalloproteinase-13	HDAC4	171052(Tax:10116)	363287(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	HDAC4 represses matrix_metalloproteinase-13 transcription in osteoblastic cells , and parathyroid_hormone controls this repression .
24126863	0	matrix_metalloproteinase-13	27,54	Interleukin-1b	0,14	matrix metalloproteinase-13	Interleukin-1b	171052(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-1b upregulates matrix_metalloproteinase-13 gene expression via c-Jun_N-terminal_kinase and p38 MAPK pathways in rat hepatic stellate cells .
23218521	0	matrix_metalloproteinase-13	14,41	MMP-13	43,49	matrix metalloproteinase-13	MMP-13	395683(Tax:9031)	395683(Tax:9031)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- in the testes of growing and adult chicken .
15246963	0	matrix_metalloproteinase-13	20,47	TGF-beta1	0,9	matrix metalloproteinase-13	TGF-beta1	4322	7040	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	TGF-beta1 modulates matrix_metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK , PI3-kinase , AKT , and p70S6k .
15662627	0	matrix_metalloproteinase-13	68,95	TGF-beta1	11,20	matrix metalloproteinase-13	TGF-beta1	4322	7040	Gene	Gene	treatment|amod|START_ENTITY up-regulation|nmod|treatment correlated|nmod|up-regulation correlated|nsubjpass|expression expression|compound|END_ENTITY	Suppressed TGF-beta1 expression is correlated with up-regulation of matrix_metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment .
12878172	0	matrix_metalloproteinase-13	13,40	TNF-alpha	60,69	matrix metalloproteinase-13	TNF-alpha	4322	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of matrix_metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases , AP-1 , and NF-kappaB transcription factors in articular chondrocytes .
24385683	0	matrix_metalloproteinase-13	18,45	Thrombin	0,8	matrix metalloproteinase-13	Thrombin	4322	2147	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Thrombin promotes matrix_metalloproteinase-13 expression through the PKC c-Src/EGFR/PI3K / Akt/AP -1 signaling pathway in human chondrocytes .
17683952	0	matrix_metalloproteinase-13	37,64	alpha-MSH	0,9	matrix metalloproteinase-13	alpha-MSH	4322	5443	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	alpha-MSH inhibits TNF-alpha-induced matrix_metalloproteinase-13 expression by modulating p38 kinase and nuclear factor kappaB signaling in human chondrosarcoma HTB-94 cells .
22102411	0	matrix_metalloproteinase-13	56,83	interleukin-1b	7,21	matrix metalloproteinase-13	interleukin-1b	4322	3553	Gene	Gene	factors|amod|START_ENTITY element|nmod|factors IL-1b|dep|element IL-1b|amod|END_ENTITY	Distal interleukin-1b -LRB- IL-1b -RRB- response element of human matrix_metalloproteinase-13 -LRB- MMP-13 -RRB- binds activator_protein_1 -LRB- AP-1 -RRB- transcription factors and regulates gene expression .
22920551	0	matrix_metalloproteinase-13	69,96	interleukin-1b	108,122	matrix metalloproteinase-13	interleukin-1b	4322	3553	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Low-intensity pulsed ultrasound inhibits messenger RNA expression of matrix_metalloproteinase-13 induced by interleukin-1b in chondrocytes in an intensity-dependent manner .
16368545	0	matrix_metalloproteinase-13_and_tissue_inhibitor_of_matrix_metalloproteinase-1	14,92	WNT3A	112,117	matrix metalloproteinase-13 and tissue inhibitor of matrix metalloproteinase-1	WNT3A	17386(Tax:10090)	22416(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-13_and_tissue_inhibitor_of_matrix_metalloproteinase-1 gene expression by WNT3A and bone_morphogenetic_protein-2 in osteoblastic differentiation .
9325265	0	matrix_metalloproteinase-14	4,31	MMP-14	33,39	matrix metalloproteinase-14	MMP-14	17387(Tax:10090)	17387(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The matrix_metalloproteinase-14 -LRB- MMP-14 -RRB- gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis .
23228395	0	matrix_metalloproteinase-15	90,117	MMP-15	119,125	matrix metalloproteinase-15	MMP-15	4324	4324	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Multiple steps of HLA-G in ovarian_carcinoma metastasis : alter NK cytotoxicity and induce matrix_metalloproteinase-15 -LRB- MMP-15 -RRB- expression .
11487149	0	matrix_metalloproteinase-1_and_tissue_inhibitor_of_metalloproteinase-1	36,106	interleukin-1alpha	126,144	matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1	interleukin-1alpha	4312	3552	Gene	Gene	expression|amod|START_ENTITY fibroblast|dobj|expression fibroblast|nmod|END_ENTITY	Induction of dental pulp fibroblast matrix_metalloproteinase-1_and_tissue_inhibitor_of_metalloproteinase-1 gene expression by interleukin-1alpha and tumor_necrosis_factor-alpha through a prostaglandin-dependent pathway .
17695512	0	matrix_metalloproteinase-1_and_vascular_endothelial_growth_factor	38,103	HTERT	0,5	matrix metalloproteinase-1 and vascular endothelial growth factor	HTERT	4312;7422	7015	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|amod|END_ENTITY	HTERT mRNA expression correlates with matrix_metalloproteinase-1_and_vascular_endothelial_growth_factor expression in human breast_cancer : a correlative study using RT-PCR .
9134100	0	matrix_metalloproteinase-2	33,59	72-kDa_gelatinase	14,31	matrix metalloproteinase-2	72-kDa gelatinase	17390(Tax:10090)	17390(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of 72-kDa_gelatinase -LRB- matrix_metalloproteinase-2 -RRB- in the developing mouse craniofacial complex .
12753080	0	matrix_metalloproteinase-2	59,85	A_beta	11,17	matrix metalloproteinase-2	A beta	4313	351	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Pathogenic A_beta induces the expression and activation of matrix_metalloproteinase-2 in human cerebrovascular smooth muscle cells .
16378600	0	matrix_metalloproteinase-2	48,74	CCL23	19,24	matrix metalloproteinase-2	CCL23	4313	6368	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Human CC chemokine CCL23 enhances expression of matrix_metalloproteinase-2 and invasion of vascular endothelial cells .
22210353	0	matrix_metalloproteinase-2	125,151	CREB	174,178	matrix metalloproteinase-2	CREB	4313	1385	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Dioscorea nipponica Makino inhibits migration and invasion of human oral_cancer HSC-3 cells by transcriptional inhibition of matrix_metalloproteinase-2 through modulation of CREB and AP-1 activity .
11723120	0	matrix_metalloproteinase-2	160,186	Discoidin_domain_receptor_2	0,27	matrix metalloproteinase-2	Discoidin domain receptor 2	17390(Tax:10090)	18214(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Discoidin_domain_receptor_2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix_metalloproteinase-2 .
22340517	0	matrix_metalloproteinase-2	43,69	E-cadherin	19,29	matrix metalloproteinase-2	E-cadherin	4313	999	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Hypoxia suppresses E-cadherin and enhances matrix_metalloproteinase-2 expression favoring esophageal_carcinoma migration and invasion via hypoxia_inducible_factor-1_alpha activation .
17099140	0	matrix_metalloproteinase-2	27,53	EGR-1	67,72	matrix metalloproteinase-2	EGR-1	4313	1958	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Cigarette smoke stimulates matrix_metalloproteinase-2 activity via EGR-1 in human lung fibroblasts .
16699069	0	matrix_metalloproteinase-2	44,70	FosB	110,114	matrix metalloproteinase-2	FosB	17390(Tax:10090)	14282(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Cardiac_ischemia-reperfusion injury induces matrix_metalloproteinase-2 expression through the AP-1 components FosB and JunB .
10840163	0	matrix_metalloproteinase-2	61,87	Granulocyte-macrophage_colony-stimulating_factor	0,48	matrix metalloproteinase-2	Granulocyte-macrophage colony-stimulating factor	4313	1437	Gene	Gene	upregulates|amod|START_ENTITY upregulates|amod|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor upregulates matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- and membrane_type-1_MMP -LRB- MT1-MMP -RRB- in human head_and_neck_cancer cells .
11451381	0	matrix_metalloproteinase-2	76,102	H-ras	108,113	matrix metalloproteinase-2	H-ras	4313	3265	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	Phorbol_ester tumour promoter mediated altered expression and regulation of matrix_metalloproteinase-2 in a H-ras transformed cell line capable of benign tumour formation .
11681709	0	matrix_metalloproteinase-2	69,95	Insulin_like_growth_factor-1	0,28	matrix metalloproteinase-2	Insulin like growth factor-1	4313	3479	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	Insulin_like_growth_factor-1 selectively regulates the expression of matrix_metalloproteinase-2 in malignant H-ras transformed cells .
15272234	0	matrix_metalloproteinase-2	29,55	Interleukin-1beta	0,17	matrix metalloproteinase-2	Interleukin-1beta	4313	3553	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-1beta stimulates matrix_metalloproteinase-2 expression via a prostaglandin_E2-dependent mechanism in human chondrocytes .
16987994	0	matrix_metalloproteinase-2	55,81	Interleukin-1beta	0,17	matrix metalloproteinase-2	Interleukin-1beta	4313	3553	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-1beta increases expression and activity of matrix_metalloproteinase-2 in cardiac microvascular endothelial cells : role of PKCalpha/beta1 and MAPKs .
19671357	0	matrix_metalloproteinase-2	31,57	Interleukin-1beta	1,18	matrix metalloproteinase-2	Interleukin-1beta	4313	3553	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	-LSB- Interleukin-1beta upregulates matrix_metalloproteinase-2 expression and activity in cardiac fibroblasts via nitric_oxide synthase pathway -RSB- .
16964412	0	matrix_metalloproteinase-2	69,95	LY52	38,42	matrix metalloproteinase-2	LY52	4313	12484(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	Using caffeoyl_pyrrolidine derivative LY52 , a potential inhibitor of matrix_metalloproteinase-2 , to suppress tumor invasion and metastasis .
12238810	0	matrix_metalloproteinase-2	27,53	MMP-2	55,60	matrix metalloproteinase-2	MMP-2	81686(Tax:10116)	81686(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and activity of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- in the development of rat first molar tooth germ .
14530987	0	matrix_metalloproteinase-2	79,105	MMP-2	107,112	matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Influence of cultured dermal fibroblasts on human melanoma cell proliferation , matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- expression and invasion in vitro .
16309203	0	matrix_metalloproteinase-2	20,46	MMP-2	48,53	matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic value of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- expression in endometrial_endometrioid_adenocarcinoma .
16929121	0	matrix_metalloproteinase-2	14,40	MMP-2	42,47	matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Evaluation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- activity with film in situ zymography for improved cytological diagnosis of breast_tumors .
17435175	0	matrix_metalloproteinase-2	14,40	MMP-2	42,47	matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- activity by phosphorylation .
18974156	0	matrix_metalloproteinase-2	14,40	MMP-2	42,47	matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2 .
25767848	0	matrix_metalloproteinase-2	38,64	MMP-2	66,71	matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Captopril and lisinopril only inhibit matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- activity at millimolar concentrations .
9879815	0	matrix_metalloproteinase-2	36,62	MMP-2	64,69	matrix metalloproteinase-2	MMP-2	4313	4313	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Tumor progression and expression of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- mRNA by human urinary bladder_cancer cells .
23038275	0	matrix_metalloproteinase-2	15,41	SIRT1	0,5	matrix metalloproteinase-2	SIRT1	4313	23411	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	SIRT1 enhances matrix_metalloproteinase-2 expression and tumor cell invasion in prostate_cancer cells .
16428937	0	matrix_metalloproteinase-2	20,46	SPARC	97,102	matrix metalloproteinase-2	SPARC	4313	6678	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of Ukrain on matrix_metalloproteinase-2 and Secreted_Protein_Acidic_and_Rich_in_Cysteine -LRB- SPARC -RRB- expression in human glioblastoma cells .
15632190	0	matrix_metalloproteinase-2	77,103	Smad7	119,124	matrix metalloproteinase-2	Smad7	4313	4092	Gene	Gene	production|amod|START_ENTITY production|nmod|expression expression|amod|END_ENTITY	The amyloid-beta peptide suppresses transforming_growth_factor-beta1-induced matrix_metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells .
12844104	0	matrix_metalloproteinase-2	25,51	Thrombospondin-1	0,16	matrix metalloproteinase-2	Thrombospondin-1	282872(Tax:9913)	281530(Tax:9913)	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Thrombospondin-1 induces matrix_metalloproteinase-2 activation in vascular smooth muscle cells .
10984610	0	matrix_metalloproteinase-2	70,96	Tissue_factor_pathway_inhibitor-2	0,33	matrix metalloproteinase-2	Tissue factor pathway inhibitor-2	4313	7980	Gene	Gene	production|nmod|START_ENTITY suppresses|dobj|production suppresses|nsubj|END_ENTITY	Tissue_factor_pathway_inhibitor-2 suppresses the production of active matrix_metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes .
19324884	0	matrix_metalloproteinase-2	34,60	Tissue_transglutaminase	0,23	matrix metalloproteinase-2	Tissue transglutaminase	4313	7052	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Tissue_transglutaminase regulates matrix_metalloproteinase-2 in ovarian_cancer by modulating cAMP-response element-binding protein activity .
19324884	0	matrix_metalloproteinase-2	34,60	Tissue_transglutaminase	0,23	matrix metalloproteinase-2	Tissue transglutaminase	4313	7052	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Tissue_transglutaminase regulates matrix_metalloproteinase-2 in ovarian_cancer by modulating cAMP-response element-binding protein activity .
17469009	0	matrix_metalloproteinase-2	71,97	Vascular_endothelial_growth_factor	0,34	matrix metalloproteinase-2	Vascular endothelial growth factor	4313	7422	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces endothelin-1 production via matrix_metalloproteinase-2 rather than endothelin-converting_enzyme-1 .
10506224	0	matrix_metalloproteinase-2	40,66	angiostatin	14,25	matrix metalloproteinase-2	angiostatin	17390(Tax:10090)	18815(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|compound|END_ENTITY	Regulation of angiostatin production by matrix_metalloproteinase-2 in a model of concomitant resistance .
23299078	0	matrix_metalloproteinase-2	43,69	apolipoprotein_A-I	21,39	matrix metalloproteinase-2	apolipoprotein A-I	100009000(Tax:9986)	100009253(Tax:9986)	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Inhibitory effect of apolipoprotein_A-I on matrix_metalloproteinase-2 expression in vivo and in vitro .
15239346	0	matrix_metalloproteinase-2	27,53	cathepsin_D	55,66	matrix metalloproteinase-2	cathepsin D	4313	1509	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of matrix_metalloproteinase-2 , cathepsin_D , and tenascin-C expression in colorectal_carcinoma .
10559137	0	matrix_metalloproteinase-2	9,35	endothelin-1	48,60	matrix metalloproteinase-2	endothelin-1	4313	1906	Gene	Gene	cleaves|amod|START_ENTITY yielding|nsubj|cleaves yielding|dep|END_ENTITY	Vascular matrix_metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor .
17469009	0	matrix_metalloproteinase-2	71,97	endothelin-1	43,55	matrix metalloproteinase-2	endothelin-1	4313	1906	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Vascular_endothelial_growth_factor induces endothelin-1 production via matrix_metalloproteinase-2 rather than endothelin-converting_enzyme-1 .
16575904	0	matrix_metalloproteinase-2	13,39	p16	0,3	matrix metalloproteinase-2	p16	4313	1029	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	p16 inhibits matrix_metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription .
16707418	0	matrix_metalloproteinase-2	56,82	phosphoinositide_3-kinase	98,123	matrix metalloproteinase-2	phosphoinositide 3-kinase	4313	5293	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Bcl-w promotes gastric_cancer cell invasion by inducing matrix_metalloproteinase-2 expression via phosphoinositide_3-kinase , Akt , and Sp1 .
9679953	0	matrix_metalloproteinase-2	54,80	plasmin	101,108	matrix metalloproteinase-2	plasmin	4313	5340	Gene	Gene	START_ENTITY|nmod|degradation degradation|nmod|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 protection of matrix_metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate_alendronate .
11423724	0	matrix_metalloproteinase-2	23,49	transforming_growth_factor-beta1	86,118	matrix metalloproteinase-2	transforming growth factor-beta1	81686(Tax:10116)	59086(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY decreases|dobj|activity decreases|nmod|cells cells|nmod|END_ENTITY	High glucose decreases matrix_metalloproteinase-2 activity in rat mesangial cells via transforming_growth_factor-beta1 .
15226662	0	matrix_metalloproteinase-2	88,114	transforming_growth_factor-beta1	52,84	matrix metalloproteinase-2	transforming growth factor-beta1	4313	7040	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effect of cyclical mechanical stretch and exogenous transforming_growth_factor-beta1 on matrix_metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head .
9417058	0	matrix_metalloproteinase-2	27,53	vitronectin	7,18	matrix metalloproteinase-2	vitronectin	17390(Tax:10090)	22370(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Intact vitronectin induces matrix_metalloproteinase-2 and tissue_inhibitor_of_metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells .
12202640	0	matrix_metalloproteinase-20	20,47	MMP-20	49,55	matrix metalloproteinase-20	MMP-20	64386	64386	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	The localization of matrix_metalloproteinase-20 -LRB- MMP-20 , enamelysin -RRB- in mature human teeth .
17223283	0	matrix_metalloproteinase-20	39,66	MMP20	68,73	matrix metalloproteinase-20	MMP20	64386	64386	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Identification and characterization of matrix_metalloproteinase-20 -LRB- MMP20 ; enamelysin -RRB- genes in reptile and amphibian .
19212832	0	matrix_metalloproteinase-3	37,63	Autotaxin	0,9	matrix metalloproteinase-3	Autotaxin	4314	5168	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Autotaxin promotes the expression of matrix_metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells .
12608905	0	matrix_metalloproteinase-3	57,83	Basic_fibroblast_growth_factor	0,30	matrix metalloproteinase-3	Basic fibroblast growth factor	4314	2247	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Basic_fibroblast_growth_factor induces the expression of matrix_metalloproteinase-3 in human periodontal ligament cells through the MEK2 mitogen-activated protein kinase pathway .
10672313	0	matrix_metalloproteinase-3	26,52	MMP-3	54,59	matrix metalloproteinase-3	MMP-3	4314	4314	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Selective distribution of matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- in Alzheimer 's _ disease brain .
15993717	0	matrix_metalloproteinase-3	19,45	MMP-3	47,52	matrix metalloproteinase-3	MMP-3	4314	4314	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Association of the matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- promoter polymorphism with celiac_disease in male subjects .
20822909	0	matrix_metalloproteinase-3	33,59	MMP-3	61,66	matrix metalloproteinase-3	MMP-3	4314	4314	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The rs522616 polymorphism in the matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- gene is associated with sporadic brain_arteriovenous_malformation in a Chinese population .
24682924	0	matrix_metalloproteinase-3	13,39	MMP-3	41,46	matrix metalloproteinase-3	MMP-3	4314	4314	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- expression in the microglia by lipopolysaccharide -LRB- LPS -RRB- via upregulation of glycoprotein_nonmetastatic_melanoma_B -LRB- GPNMB -RRB- expression .
20360864	0	matrix_metalloproteinase-3	30,56	NFkappaB	86,94	matrix metalloproteinase-3	NFkappaB	4314	4790	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Allele-specific regulation of matrix_metalloproteinase-3 gene by transcription factor NFkappaB .
17525194	0	matrix_metalloproteinase-3	46,72	TNF_and_IL-1	13,25	matrix metalloproteinase-3	TNF and IL-1	4314	7124;3552	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Synergism of TNF_and_IL-1 in the induction of matrix_metalloproteinase-3 in trabecular meshwork .
12189113	0	matrix_metalloproteinase-3	11,37	inhibitor-1	67,78	matrix metalloproteinase-3	inhibitor-1	4314	5502	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Myocardial matrix_metalloproteinase-3 and matrix metalloproteinase inhibitor-1 expression in congestive_heart_failure .
9203094	0	matrix_metalloproteinase-3	33,59	interleukin-1_beta	11,29	matrix metalloproteinase-3	interleukin-1 beta	4314	3553	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Effects of interleukin-1_beta on matrix_metalloproteinase-3 levels in human periodontal ligament cells .
12759241	0	matrix_metalloproteinase-7	12,38	E-cadherin	49,59	matrix metalloproteinase-7	E-cadherin	17393(Tax:10090)	12550(Tax:10090)	Gene	Gene	Matrilysin|dep|START_ENTITY mediates|nsubj|Matrilysin mediates|dobj|ectodomain ectodomain|amod|END_ENTITY	Matrilysin -LRB- matrix_metalloproteinase-7 -RRB- mediates E-cadherin ectodomain shedding in injured lung epithelium .
16969501	0	matrix_metalloproteinase-7	33,59	E-cadherin	21,31	matrix metalloproteinase-7	E-cadherin	4316	999	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Relationship between E-cadherin , matrix_metalloproteinase-7 gene expression and clinicopathological features in gastric_carcinoma .
16103088	0	matrix_metalloproteinase-7	60,86	Insulin-like_growth_factor_binding_protein-5	0,44	matrix metalloproteinase-7	Insulin-like growth factor binding protein-5	4316	3488	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein-5 is a target of matrix_metalloproteinase-7 : implications for epithelial-mesenchymal signaling .
11927011	0	matrix_metalloproteinase-7	27,53	MMP-7	55,60	matrix metalloproteinase-7	MMP-7	4316	4316	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of matrix_metalloproteinase-7 -LRB- MMP-7 -RRB- expression at the invasive front in gastric_carcinoma .
10514384	0	matrix_metalloproteinase-7	45,71	beta-catenin	0,12	matrix metalloproteinase-7	beta-catenin	4316	1499	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	beta-catenin regulates the expression of the matrix_metalloproteinase-7 in human colorectal_cancer .
16158183	0	matrix_metalloproteinase-7	82,108	beta-catenin	133,145	matrix metalloproteinase-7	beta-catenin	4316	1499	Gene	Gene	START_ENTITY|acl|associated associated|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	A subset of high-grade pulmonary_neuroendocrine_carcinomas shows up-regulation of matrix_metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity , independent of EGFR and HER-2_gene_amplification or expression .
16804904	0	matrix_metalloproteinase-7	27,53	beta-catenin	103,115	matrix metalloproteinase-7	beta-catenin	4316	1499	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|expression expression|amod|END_ENTITY	Prognostic significance of matrix_metalloproteinase-7 in epithelial_ovarian_cancer and its relation to beta-catenin expression .
22076613	0	matrix_metalloproteinase-7	44,70	c-Fos	104,109	matrix metalloproteinase-7	c-Fos	4316	2353	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Tissue factor/activated factor VIIa induces matrix_metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon_cancer cell .
24613844	0	matrix_metalloproteinase-7	78,104	syndecan-2	50,60	matrix metalloproteinase-7	syndecan-2	4316	6383	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	Interleukin-1a promotes extracellular shedding of syndecan-2 via induction of matrix_metalloproteinase-7 expression .
15672011	0	matrix_metalloproteinase-8	28,54	MMP-8	56,61	matrix metalloproteinase-8	MMP-8	4317	4317	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Midtrimester amniotic fluid matrix_metalloproteinase-8 -LRB- MMP-8 -RRB- levels above the 90th percentile are a marker for subsequent preterm premature rupture_of_membranes .
17254561	0	matrix_metalloproteinase-8	20,46	MMP-8	48,53	matrix metalloproteinase-8	MMP-8	4317	4317	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Correlates of serum matrix_metalloproteinase-8 -LRB- MMP-8 -RRB- concentrations in nondiabetic subjects without cardiovascular_disease .
16409253	0	matrix_metalloproteinase-8	53,79	collagenase-2	38,51	matrix metalloproteinase-8	collagenase-2	4317	4317	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Capsaicin-induced local elevations in collagenase-2 -LRB- matrix_metalloproteinase-8 -RRB- levels in human gingival crevice fluid .
16870179	0	matrix_metalloproteinase-9	43,69	Akt	89,92	matrix metalloproteinase-9	Akt	4318	207	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Activation of toll-like_receptor-9 induces matrix_metalloproteinase-9 expression through Akt and tumor_necrosis_factor-alpha signaling .
23157807	0	matrix_metalloproteinase-9	41,67	C-reactive_protein	0,18	matrix metalloproteinase-9	C-reactive protein	4318	1401	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	C-reactive_protein induces expression of matrix_metalloproteinase-9 : a possible link between inflammation and plaque_rupture .
20126378	0	matrix_metalloproteinase-9	31,57	CCL15	16,21	matrix metalloproteinase-9	CCL15	4318	6359	Gene	Gene	release|amod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Chemokine Lkn-1 / CCL15 enhances matrix_metalloproteinase-9 release from human macrophages and macrophage-derived foam cells .
15034761	0	matrix_metalloproteinase-9	14,40	CD34	55,59	matrix metalloproteinase-9	CD34	4318	947	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Production of matrix_metalloproteinase-9 by cord blood CD34 + cells and its role in migration .
17689859	0	matrix_metalloproteinase-9	121,147	CHM-1	0,5	matrix metalloproteinase-9	CHM-1	4318	11061	Gene	Gene	expression|amod|START_ENTITY suppressing|dobj|expression inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	CHM-1 inhibits hepatocyte_growth_factor-induced invasion of SK-Hep-1 human hepatocellular_carcinoma cells by suppressing matrix_metalloproteinase-9 expression .
17916907	0	matrix_metalloproteinase-9	15,41	CXCR4	75,80	matrix metalloproteinase-9	CXCR4	4318	7852	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|pathway pathway|nummod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in stromal_cell-derived_factor-1 / CXCR4 pathway of lung_cancer metastasis .
24912620	0	matrix_metalloproteinase-9	137,163	Chemokine_receptor_7	0,20	matrix metalloproteinase-9	Chemokine receptor 7	4318	1236	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Chemokine_receptor_7 enhances cell chemotaxis and migration of metastatic squamous_cell_carcinoma_of_head_and_neck through activation of matrix_metalloproteinase-9 .
15247301	0	matrix_metalloproteinase-9	74,100	Class_II_major_histocompatibility_complex_transactivator	0,56	matrix metalloproteinase-9	Class II major histocompatibility complex transactivator	4318	4261	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Class_II_major_histocompatibility_complex_transactivator -LRB- CIITA -RRB- inhibits matrix_metalloproteinase-9 gene expression .
18303430	0	matrix_metalloproteinase-9	126,152	E-cadherin	184,194	matrix metalloproteinase-9	E-cadherin	4318	999	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|END_ENTITY	Tumor response to combination celecoxib and erlotinib therapy in non-small_cell_lung_cancer is associated with a low baseline matrix_metalloproteinase-9 and a decline in serum-soluble E-cadherin .
26514923	0	matrix_metalloproteinase-9	16,42	EGFR	72,76	matrix metalloproteinase-9	EGFR	4318	13649(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cadmium induces matrix_metalloproteinase-9 expression via ROS-dependent EGFR , NF - B , and AP-1 pathways in human endothelial cells .
15504454	0	matrix_metalloproteinase-9	83,109	EGF_receptor	47,59	matrix metalloproteinase-9	EGF receptor	4318	1956	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Roles of mitogen activated protein kinases and EGF_receptor in arsenite-stimulated matrix_metalloproteinase-9 production .
12490006	0	matrix_metalloproteinase-9	18,44	ERK	88,91	matrix metalloproteinase-9	ERK	17395(Tax:10090)	26413(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of matrix_metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain_injury .
15854510	0	matrix_metalloproteinase-9	45,71	ERK	91,94	matrix metalloproteinase-9	ERK	17395(Tax:10090)	26413(Tax:10090)	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nmod|pathway pathway|compound|END_ENTITY	-LSB- Transforming_growth_factor-beta1 stimulates matrix_metalloproteinase-9 production through ERK activation pathway and upregulation of Ets-1 protein -RSB- .
17114644	0	matrix_metalloproteinase-9	37,63	ERK	104,107	matrix metalloproteinase-9	ERK	4318	5594	Gene	Gene	activation|amod|START_ENTITY suppresses|dobj|activation suppresses|nmod|Ras/Raf/MEK Ras/Raf/MEK|dep|END_ENTITY	Ascofuranone suppresses PMA-mediated matrix_metalloproteinase-9 gene activation through the Ras/Raf/MEK / ERK - and Ap1-dependent mechanisms .
19371720	0	matrix_metalloproteinase-9	41,67	ERK	108,111	matrix metalloproteinase-9	ERK	4318	5594	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|cells cells|nmod|pathways pathways|compound|END_ENTITY	Transforming growth factor-beta1 induces matrix_metalloproteinase-9 expression in human meningeal cells via ERK and Smad pathways .
25724188	0	matrix_metalloproteinase-9	14,40	ERK	109,112	matrix metalloproteinase-9	ERK	4318	5594	Gene	Gene	MMP-9|amod|START_ENTITY Activation|nmod|MMP-9 promotes|nsubj|Activation promotes|nmod|END_ENTITY	Activation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by neurotensin promotes cell invasion and migration through ERK pathway in gastric_cancer .
14734780	0	matrix_metalloproteinase-9	34,60	Ets-1	0,5	matrix metalloproteinase-9	Ets-1	4318	2113	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ets-1 regulates TNF-alpha-induced matrix_metalloproteinase-9 and tenascin expression in primary bronchial fibroblasts .
12947332	0	matrix_metalloproteinase-9	84,110	Glial_cell-derived_neurotrophic_factor	0,38	matrix metalloproteinase-9	Glial cell-derived neurotrophic factor	4318	2668	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Glial_cell-derived_neurotrophic_factor upregulates the expression and activation of matrix_metalloproteinase-9 in human pancreatic_cancer .
18483307	0	matrix_metalloproteinase-9	83,109	Heme_oxygenase-1	0,16	matrix metalloproteinase-9	Heme oxygenase-1	4318	3162	Gene	Gene	expression|nmod|START_ENTITY suppressing|dobj|expression breast_cancer_invasion|acl|suppressing inhibits|dobj|breast_cancer_invasion inhibits|nsubj|END_ENTITY	Heme_oxygenase-1 inhibits breast_cancer_invasion via suppressing the expression of matrix_metalloproteinase-9 .
11673527	0	matrix_metalloproteinase-9	31,57	IFN-gamma	77,86	matrix metalloproteinase-9	IFN-gamma	4318	3458	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcriptional suppression of matrix_metalloproteinase-9 gene expression by IFN-gamma and IFN-beta : critical role of STAT-1alpha .
22159401	0	matrix_metalloproteinase-9	35,61	Keratinocyte_growth_factor	0,26	matrix metalloproteinase-9	Keratinocyte growth factor	4318	2252	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Keratinocyte_growth_factor induces matrix_metalloproteinase-9 expression and correlates with venous_invasion in pancreatic_cancer .
22167195	0	matrix_metalloproteinase-9	80,106	Late_SV40_factor	0,16	matrix metalloproteinase-9	Late SV40 factor	4318	7024	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Late_SV40_factor -LRB- LSF -RRB- enhances angiogenesis by transcriptionally up-regulating matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- .
10224058	0	matrix_metalloproteinase-9	14,40	MMP-9	42,47	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- via a converging plasmin/stromelysin -1 cascade enhances tumor cell invasion .
11438179	0	matrix_metalloproteinase-9	77,103	MMP-9	105,110	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Development of an ultrasensitive enzyme immunoassay for the determination of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- levels in normal human cerebrospinal fluid .
11529928	0	matrix_metalloproteinase-9	25,51	MMP-9	53,58	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated serum levels of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in Kawasaki_disease .
11912173	0	matrix_metalloproteinase-9	14,40	MMP-9	42,47	matrix metalloproteinase-9	MMP-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by translational efficiency in murine prostate_carcinoma cells .
12929930	0	matrix_metalloproteinase-9	93,119	MMP-9	121,126	matrix metalloproteinase-9	MMP-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- recruits osteoclast precursors by inducing chemotaxis , matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- activity , and collagen transmigration .
16475914	0	matrix_metalloproteinase-9	9,35	MMP-9	37,42	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Systemic matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- levels as prognostic indexes of bone_disease in patients with multiple_myeloma .
16736997	0	matrix_metalloproteinase-9	51,77	MMP-9	79,84	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The C -LRB- -1562 -RRB- T polymorphism in the promoter of the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene and coronary_atherosclerosis -RSB- .
17034838	0	matrix_metalloproteinase-9	27,53	MMP-9	55,60	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in epithelial_ovarian_cancer .
17617834	0	matrix_metalloproteinase-9	40,66	MMP-9	68,73	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Functional -1562 _ C-to-T polymorphism in matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- promoter is associated with the risk for oral_squamous_cell_carcinoma in younger male areca users .
17889183	0	matrix_metalloproteinase-9	19,45	MMP-9	47,52	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Down-regulation of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression in the myocardium of congestive_heart_failure patients .
18194081	0	matrix_metalloproteinase-9	48,74	MMP-9	76,81	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms in the promoter of the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene are not linked with significant plasma MMP-9 variations in healthy subjects .
19264454	0	matrix_metalloproteinase-9	31,57	MMP-9	59,64	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphism of the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene in schizophrenia .
19626678	0	matrix_metalloproteinase-9	44,70	MMP-9	72,77	matrix metalloproteinase-9	MMP-9	100008993(Tax:9986)	100008993(Tax:9986)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cytokines and signaling pathways regulating matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression in corneal epithelial cells .
19921474	0	matrix_metalloproteinase-9	27,53	MMP-9	55,60	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in stage II colorectal_carcinoma .
20197064	0	matrix_metalloproteinase-9	27,53	MMP-9	55,60	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphism of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene in alcohol_dependence : family and case control study .
20663046	0	matrix_metalloproteinase-9	32,58	MMP-9	60,65	matrix metalloproteinase-9	MMP-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Melatonin inhibits postischemic matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- activation via dual modulation of plasminogen/plasmin system and endogenous MMP inhibitor in mice subjected to transient focal cerebral_ischemia .
21077523	0	matrix_metalloproteinase-9	14,40	MMP-9	42,47	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in human midpregnancy amniotic fluid and risk of preterm_labor .
21175737	0	matrix_metalloproteinase-9	8,34	MMP-9	36,41	matrix metalloproteinase-9	MMP-9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- in striatal blood-brain barrier disruption in a 3-nitropropionic_acid model of Huntington 's _ disease .
21437990	0	matrix_metalloproteinase-9	27,53	MMP-9	55,60	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphism of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene and response to lithium prophylaxis in bipolar patients .
22730324	0	matrix_metalloproteinase-9	31,57	MMP-9	59,64	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	A 17-residue sequence from the matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- hemopexin domain binds a4b1 integrin and inhibits MMP-9-induced functions in chronic_lymphocytic_leukemia B cells .
22858217	0	matrix_metalloproteinase-9	16,42	MMP-9	44,49	matrix metalloproteinase-9	MMP-9	4318	4318	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increased serum matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- levels in young patients during bipolar_depression .
9706876	0	matrix_metalloproteinase-9	69,95	MMP-9	97,102	matrix metalloproteinase-9	MMP-9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intermittent administration of parathyroid_hormone -LRB- 1-34 -RRB- stimulates matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- expression in rat long bone .
21187089	0	matrix_metalloproteinase-9	62,88	Metallothionein-2A	0,18	matrix metalloproteinase-9	Metallothionein-2A	4318	4502	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|overexpression overexpression|amod|END_ENTITY	Metallothionein-2A overexpression increases the expression of matrix_metalloproteinase-9 and invasion of breast_cancer cells .
10580107	0	matrix_metalloproteinase-9	43,69	NF-kappaB	172,181	matrix metalloproteinase-9	NF-kappaB	4318	4790	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Human_immunodeficiency_virus-1-tat induces matrix_metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB .
15800029	0	matrix_metalloproteinase-9	14,40	NF-kappaB	124,133	matrix metalloproteinase-9	NF-kappaB	4318	4790	Gene	Gene	Production|nmod|START_ENTITY involves|nsubj|Production involves|dobj|END_ENTITY	Production of matrix_metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha / NF-kappaB pathway .
17922642	0	matrix_metalloproteinase-9	14,40	NF-kappaB	192,201	matrix metalloproteinase-9	NF-kappaB	4318	4790	Gene	Gene	transcription|amod|START_ENTITY Regulation|nmod|transcription Regulation|dep|role role|nmod|expression expression|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-9 transcription in squamous_cell_carcinoma of uterine cervix : the role of human_papillomavirus gene E2 expression and activation of transcription factor NF-kappaB .
24918635	0	matrix_metalloproteinase-9	15,41	NG2	106,109	matrix metalloproteinase-9	NG2	4318	1464	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in amyloid-b 1-42-induced shedding of the pericyte proteoglycan NG2 .
19889214	0	matrix_metalloproteinase-9	22,48	NGAL	132,136	matrix metalloproteinase-9	NGAL	4318	3934	Gene	Gene	levels|nmod|START_ENTITY levels|dep|END_ENTITY	Circulating levels of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- , neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- and their complex MMP-9 / NGAL in breast_cancer_disease .
25672645	0	matrix_metalloproteinase-9	68,94	PTPRJ	53,58	matrix metalloproteinase-9	PTPRJ	4318	5795	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Deficiency of the protein-tyrosine phosphatase DEP-1 / PTPRJ promotes matrix_metalloproteinase-9 expression in meningioma cells .
19208844	0	matrix_metalloproteinase-9	26,52	RECK	0,4	matrix metalloproteinase-9	RECK	4318	8434	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	RECK negatively regulates matrix_metalloproteinase-9 transcription .
9789069	0	matrix_metalloproteinase-9	14,40	RECK	112,116	matrix metalloproteinase-9	RECK	4318	8434	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of matrix_metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK .
19965686	0	matrix_metalloproteinase-9	39,65	STAT1	70,75	matrix metalloproteinase-9	STAT1	4318	6772	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	VEGF/VEGFR2 interaction down-regulates matrix_metalloproteinase-9 via STAT1 activation and inhibits B chronic_lymphocytic_leukemia cell migration .
20812964	0	matrix_metalloproteinase-9	38,64	Sirt1	68,73	matrix metalloproteinase-9	Sirt1	4318	23411	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of stress-induced matrix_metalloproteinase-9 by Sirt1 in skin tissue .
24894401	0	matrix_metalloproteinase-9	31,57	Sirt1	0,5	matrix metalloproteinase-9	Sirt1	17395(Tax:10090)	93759(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Sirt1 , a negative regulator of matrix_metalloproteinase-9 in diabetic_retinopathy .
11471571	0	matrix_metalloproteinase-9	51,77	TIMP-1	144,150	matrix metalloproteinase-9	TIMP-1	4318	7076	Gene	Gene	tissue_inhibitor_of_metalloproteinase-1|amod|START_ENTITY tissue_inhibitor_of_metalloproteinase-1|appos|END_ENTITY	All trans-retinoic_acid selectively down-regulates matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and up-regulates tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in human bronchoalveolar lavage cells .
16321449	0	matrix_metalloproteinase-9	16,42	TIMP-1	69,75	matrix metalloproteinase-9	TIMP-1	4318	7076	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of matrix_metalloproteinase-9 and its tissue inhibitor -LRB- TIMP-1 -RRB- in acute disseminated encephalomyelitis .
18850474	0	matrix_metalloproteinase-9	14,40	TIMP-1	99,105	matrix metalloproteinase-9	TIMP-1	4318	7076	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and tissue inhibitor of matrix metalloproteinase -LRB- TIMP-1 -RRB- in tissues with a diagnosis of childhood_lymphoma .
11073115	0	matrix_metalloproteinase-9	48,74	TNF-alpha	18,27	matrix metalloproteinase-9	TNF-alpha	4318	7124	Gene	Gene	expression|amod|START_ENTITY monocyte|dobj|expression monocyte|nsubj|stimulates stimulates|amod|END_ENTITY	Fibronectin-bound TNF-alpha stimulates monocyte matrix_metalloproteinase-9 expression and regulates chemotaxis .
16720051	0	matrix_metalloproteinase-9	83,109	TNF-alpha	113,122	matrix metalloproteinase-9	TNF-alpha	4318	7124	Gene	Gene	stimulation|nmod|START_ENTITY involved|nmod|stimulation involved|nmod|END_ENTITY	Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix_metalloproteinase-9 by TNF-alpha in human monocytes .
17276429	0	matrix_metalloproteinase-9	36,62	TNF-alpha	82,91	matrix metalloproteinase-9	TNF-alpha	4318	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Phosphatidic_acid as a regulator of matrix_metalloproteinase-9 expression via the TNF-alpha signaling pathway .
17357478	0	matrix_metalloproteinase-9	23,49	TNF-alpha	0,9	matrix metalloproteinase-9	TNF-alpha	4318	7124	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	TNF-alpha up-regulates matrix_metalloproteinase-9 expression and activity in alveolar macrophages from patients with chronic_obstructive_pulmonary_disease .
18496150	0	matrix_metalloproteinase-9	17,43	TNF-alpha	0,9	matrix metalloproteinase-9	TNF-alpha	4318	7124	Gene	Gene	drives|amod|START_ENTITY drives|amod|END_ENTITY	TNF-alpha drives matrix_metalloproteinase-9 in squamous oral_carcinogenesis .
21502320	0	matrix_metalloproteinase-9	107,133	TNF-alpha	83,92	matrix metalloproteinase-9	TNF-alpha	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
18389476	0	matrix_metalloproteinase-9	33,59	Thy-1	6,11	matrix metalloproteinase-9	Thy-1	4318	7070	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Human Thy-1 induces secretion of matrix_metalloproteinase-9 and CXCL8 from human neutrophils .
15854510	0	matrix_metalloproteinase-9	45,71	Transforming_growth_factor-beta1	1,33	matrix metalloproteinase-9	Transforming growth factor-beta1	17395(Tax:10090)	21803(Tax:10090)	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	-LSB- Transforming_growth_factor-beta1 stimulates matrix_metalloproteinase-9 production through ERK activation pathway and upregulation of Ets-1 protein -RSB- .
20177776	0	matrix_metalloproteinase-9	98,124	Urokinase-type_plasminogen_activator	0,36	matrix metalloproteinase-9	Urokinase-type plasminogen activator	4318	5328	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Urokinase-type_plasminogen_activator induces BV-2 microglial cell migration through activation of matrix_metalloproteinase-9 .
20716639	0	matrix_metalloproteinase-9	48,74	Urokinase_plasminogen_activator_receptor	0,40	matrix metalloproteinase-9	Urokinase plasminogen activator receptor	4318	5329	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Urokinase_plasminogen_activator_receptor and/or matrix_metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells .
15383417	0	matrix_metalloproteinase-9	84,110	VEGF	75,79	matrix metalloproteinase-9	VEGF	4318	7422	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	The combination assay with circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- - C , matrix_metalloproteinase-9 , and VEGF for diagnosing lymph node metastasis in patients with non-small_cell_lung_cancer .
25244493	0	matrix_metalloproteinase-9	81,107	VEGF-A	125,131	matrix metalloproteinase-9	VEGF-A	4318	7422	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Targeting filamin_B induces tumor growth and metastasis via enhanced activity of matrix_metalloproteinase-9 and secretion of VEGF-A .
14971873	0	matrix_metalloproteinase-9	51,77	Vascular_endothelial_growth_factor	0,34	matrix metalloproteinase-9	Vascular endothelial growth factor	4318	7422	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor correlates with matrix_metalloproteinase-9 in the pleural_effusion .
16645174	0	matrix_metalloproteinase-9	45,71	Vascular_endothelial_growth_factor	0,34	matrix metalloproteinase-9	Vascular endothelial growth factor	4318	7422	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor modulates matrix_metalloproteinase-9 expression in asthma .
22640735	0	matrix_metalloproteinase-9	40,66	annexin_A1	12,22	matrix metalloproteinase-9	annexin A1	4318	301	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of annexin_A1 in expression of matrix_metalloproteinase-9 and invasion of breast_cancer cells .
22675930	0	matrix_metalloproteinase-9	62,88	endothelin-1	48,60	matrix metalloproteinase-9	endothelin-1	4318	1906	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Significance expression and relationships with endothelin-1 , matrix_metalloproteinase-9 in the laryngeal_carcinoma -RSB- .
22041445	0	matrix_metalloproteinase-9	56,82	epidermal_growth_factor	11,34	matrix metalloproteinase-9	epidermal growth factor	4318	1950	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of epidermal_growth_factor on the expression of matrix_metalloproteinase-9 and the signalling pathways involved in the trophoblast cell line JEG-3 -RSB- .
15870844	0	matrix_metalloproteinase-9	28,54	gelatinase_B	14,26	matrix metalloproteinase-9	gelatinase B	4318	4318	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of gelatinase_B -LRB- matrix_metalloproteinase-9 -RRB- by dihydrolipoic_acid .
9466586	0	matrix_metalloproteinase-9	16,42	gelatinase_B	44,56	matrix metalloproteinase-9	gelatinase B	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Requirement for matrix_metalloproteinase-9 -LRB- gelatinase_B -RRB- expression in metastasis by murine prostate_carcinoma .
15969627	0	matrix_metalloproteinase-9	121,147	granulocyte_colony-stimulating_factor	46,83	matrix metalloproteinase-9	granulocyte colony-stimulating factor	17395(Tax:10090)	12985(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Hematopoietic progenitor cell mobilization by granulocyte_colony-stimulating_factor and erythropoietin in the absence of matrix_metalloproteinase-9 .
23615401	0	matrix_metalloproteinase-9	60,86	heme_oxygenase-1	13,29	matrix metalloproteinase-9	heme oxygenase-1	4318	3162	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 and inhibition of TPA-induced matrix_metalloproteinase-9 expression by andrographolide in MCF-7 human breast_cancer cells .
21646471	0	matrix_metalloproteinase-9	79,105	hemopexin	59,68	matrix metalloproteinase-9	hemopexin	4318	3263	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Small-molecule anticancer compounds selectively target the hemopexin domain of matrix_metalloproteinase-9 .
26648034	0	matrix_metalloproteinase-9	62,88	hemopexin	36,45	matrix metalloproteinase-9	hemopexin	4318	3263	Gene	Gene	gene|amod|START_ENTITY domain|nmod|gene domain|amod|END_ENTITY	Signatures of positive selection at hemopexin -LRB- PEX -RRB- domain of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- gene .
15684762	0	matrix_metalloproteinase-9	10,36	interleukin-6	80,93	matrix metalloproteinase-9	interleukin-6	4318	3569	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Increased matrix_metalloproteinase-9 in blood in association with activation of interleukin-6 after traumatic_brain_injury : influence of hypothermic therapy .
22533572	0	matrix_metalloproteinase-9	41,67	lipocalin_2	8,19	matrix metalloproteinase-9	lipocalin 2	4318	3934	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of lipocalin_2 and its complex with matrix_metalloproteinase-9 in oral_cancer .
18554282	0	matrix_metalloproteinase-9	34,60	mandibuloacral_dysplasia_type_A	78,109	matrix metalloproteinase-9	mandibuloacral dysplasia type A	4318	270	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Increased release and activity of matrix_metalloproteinase-9 in patients with mandibuloacral_dysplasia_type_A , a rare premature_ageing_syndrome .
25704757	0	matrix_metalloproteinase-9	56,82	mucin	36,41	matrix metalloproteinase-9	mucin	4318	100508689	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of high glucose-mediated mucin expression by matrix_metalloproteinase-9 in human airway epithelial cells .
16061852	0	matrix_metalloproteinase-9	4,30	neutrophil_gelatinase-associated_lipocalin	31,73	matrix metalloproteinase-9	neutrophil gelatinase-associated lipocalin	4318	3934	Gene	Gene	complex|dep|START_ENTITY complex|amod|END_ENTITY	The matrix_metalloproteinase-9 / neutrophil_gelatinase-associated_lipocalin complex plays a role in breast_tumor growth and is present in the urine of breast_cancer patients .
15956726	0	matrix_metalloproteinase-9	16,42	nuclear_factor_kappa_B	65,87	matrix metalloproteinase-9	nuclear factor kappa B	4318	4790	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Relaxin induces matrix_metalloproteinase-9 through activation of nuclear_factor_kappa_B in human THP-1 cells .
22197032	0	matrix_metalloproteinase-9	137,163	occludin	91,99	matrix metalloproteinase-9	occludin	4318	100506658	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix_metalloproteinase-9 .
17916907	0	matrix_metalloproteinase-9	15,41	stromal_cell-derived_factor-1	45,74	matrix metalloproteinase-9	stromal cell-derived factor-1	4318	6387	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in stromal_cell-derived_factor-1 / CXCR4 pathway of lung_cancer metastasis .
10808169	0	matrix_metalloproteinase-9	7,33	tissue_inhibitor_of_metalloproteinase-1	35,74	matrix metalloproteinase-9	tissue inhibitor of metalloproteinase-1	4318	7076	Gene	Gene	ratio|dep|START_ENTITY ratio|amod|END_ENTITY	Sputum matrix_metalloproteinase-9 : tissue_inhibitor_of_metalloproteinase-1 ratio in acute asthma .
12099554	0	matrix_metalloproteinase-9	91,117	transforming_growth_factor-alpha	13,45	matrix metalloproteinase-9	transforming growth factor-alpha	17395(Tax:10090)	21802(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Influence of transforming_growth_factor-alpha on expression of matrix_metalloproteinase-2 , matrix_metalloproteinase-9 , and epidermal_growth_factor_receptor gene in the mouse blastocysts .
20332214	0	matrix_metalloproteinase-9	52,78	tumor_necrosis_factor_alpha	96,123	matrix metalloproteinase-9	tumor necrosis factor alpha	4318	7124	Gene	Gene	transcription|amod|START_ENTITY essential|nmod|transcription essential|nmod|END_ENTITY	Transcription factor Egr-1 is essential for maximal matrix_metalloproteinase-9 transcription by tumor_necrosis_factor_alpha .
21502320	0	matrix_metalloproteinase-9	107,133	tumor_necrosis_factor_alpha	54,81	matrix metalloproteinase-9	tumor necrosis factor alpha	17395(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
11606713	0	matrix_metalloproteinase-9	80,106	vascular_endothelial_growth_factor	127,161	matrix metalloproteinase-9	vascular endothelial growth factor	17395(Tax:10090)	22339(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix_metalloproteinase-9 and mobilization of vascular_endothelial_growth_factor .
14530359	0	matrix_metalloproteinase-9	17,43	vascular_endothelial_growth_factor	95,129	matrix metalloproteinase-9	vascular endothelial growth factor	17395(Tax:10090)	22339(Tax:10090)	Gene	Gene	lymphocytes|amod|START_ENTITY Up-regulation|nmod|lymphocytes Up-regulation|dep|role role|nmod|END_ENTITY	Up-regulation of matrix_metalloproteinase-9 in T lymphocytes of mammary_tumor bearers : role of vascular_endothelial_growth_factor .
16395286	0	matrix_metalloproteinase-9	50,76	vascular_endothelial_growth_factor	83,117	matrix metalloproteinase-9	vascular endothelial growth factor	17395(Tax:10090)	22339(Tax:10090)	Gene	Gene	tetracyclines|nmod|START_ENTITY effect|nmod|tetracyclines effect|nmod|hyperstimulation hyperstimulation|compound|END_ENTITY	Dose-response effect of tetracyclines on cerebral matrix_metalloproteinase-9 after vascular_endothelial_growth_factor hyperstimulation .
11237433	0	matrix_metalloproteinase-9_and_tissue_inhibitor_of_metalloproteinase-1	40,110	Interleukin_15	0,14	matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1	Interleukin 15	4318	3600	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin_15 stimulates production of matrix_metalloproteinase-9_and_tissue_inhibitor_of_metalloproteinase-1 by human peripheral blood mononuclear cells .
22297496	0	matrix_metalloproteinase_1	47,73	TSG-6	0,5	matrix metalloproteinase 1	TSG-6	4312	7130	Gene	Gene	transcription|nmod|START_ENTITY controls|dobj|transcription controls|nsubj|END_ENTITY	TSG-6 controls transcription and activation of matrix_metalloproteinase_1 in conjunctivochalasis .
9690907	0	matrix_metalloproteinase_1	42,68	interleukin_4	11,24	matrix metalloproteinase 1	interleukin 4	4312	3565	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for interleukin_4 in production of matrix_metalloproteinase_1 by human aortic smooth_muscle_cells .
17363400	0	matrix_metalloproteinase_1	98,124	interleukin_6	126,139	matrix metalloproteinase 1	interleukin 6	4312	3569	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Genetic susceptibility to total hip arthroplasty failure : a preliminary study on the influence of matrix_metalloproteinase_1 , interleukin_6 polymorphisms and vitamin_D_receptor .
15987457	0	matrix_metalloproteinase_12	29,56	MMP12	63,68	matrix metalloproteinase 12	MMP12	4321	4321	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms in the matrix_metalloproteinase_12 gene -LRB- MMP12 -RRB- and breast_cancer risk and survival : the Shanghai Breast_Cancer Study .
24504547	0	matrix_metalloproteinase_13	41,68	Interleukin-11	0,14	matrix metalloproteinase 13	Interleukin-11	4322	3589	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-11 induces the expression of matrix_metalloproteinase_13 in gastric_cancer SCH cells partly via the PI3K-AKT and JAK-STAT3 pathways .
16308103	0	matrix_metalloproteinase_13	50,77	Janus_kinase_3	27,41	matrix metalloproteinase 13	Janus kinase 3	17386(Tax:10090)	16453(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of Janus_kinase_3 -LRB- JAK3 -RRB- , matrix_metalloproteinase_13 -LRB- MMP13 -RRB- , heat_shock protein 60 -LRB- HSP60 -RRB- , and mouse double minute 2 -LRB- MDM2 -RRB- in human colorectal_cancer progression using human cancer cDNA microarrays .
15026307	0	matrix_metalloproteinase_13	23,50	MMP-13	52,58	matrix metalloproteinase 13	MMP-13	171052(Tax:10116)	171052(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|appos|END_ENTITY	Nmp4/CIZ regulation of matrix_metalloproteinase_13 -LRB- MMP-13 -RRB- response to parathyroid_hormone in osteoblasts .
15074358	0	matrix_metalloproteinase_13	36,63	MMP-13	65,71	matrix metalloproteinase 13	MMP-13	17386(Tax:10090)	17386(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of matrix_metalloproteinase_13 -LRB- MMP-13 -RRB- in mouse mandibular condylar cartilage .
22869368	0	matrix_metalloproteinase_13	81,108	MMP13	110,115	matrix metalloproteinase 13	MMP13	17386(Tax:10090)	17386(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Osterix regulates calcification and degradation of chondrogenic matrices through matrix_metalloproteinase_13 -LRB- MMP13 -RRB- expression in association with transcription factor Runx2 during endochondral ossification .
21339746	0	matrix_metalloproteinase_13	78,105	MUC1	0,4	matrix metalloproteinase 13	MUC1	4322	4582	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	MUC1 induces metastasis in esophageal_squamous_cell_carcinoma by upregulating matrix_metalloproteinase_13 .
20131257	0	matrix_metalloproteinase_13	41,68	MicroRNA-27b	0,12	matrix metalloproteinase 13	MicroRNA-27b	4322	407019	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-27b regulates the expression of matrix_metalloproteinase_13 in human osteoarthritis chondrocytes .
16648633	0	matrix_metalloproteinase_13	35,62	NFkappaB	97,105	matrix metalloproteinase 13	NFkappaB	4322	4790	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Hyaluronan oligosaccharides induce matrix_metalloproteinase_13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes .
22869368	0	matrix_metalloproteinase_13	81,108	Osterix	0,7	matrix metalloproteinase 13	Osterix	17386(Tax:10090)	170574(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Osterix regulates calcification and degradation of chondrogenic matrices through matrix_metalloproteinase_13 -LRB- MMP13 -RRB- expression in association with transcription factor Runx2 during endochondral ossification .
22674505	0	matrix_metalloproteinase_13	54,81	Smad3	22,27	matrix metalloproteinase 13	Smad3	17386(Tax:10090)	17127(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix_metalloproteinase_13 expression to maintain articular cartilage and prevent osteoarthritis .
24819400	0	matrix_metalloproteinase_13	43,70	annexin_A2	32,42	matrix metalloproteinase 13	annexin A2	4322	302	Gene	Gene	loop|amod|START_ENTITY promotes|nsubj|loop END_ENTITY|parataxis|promotes	The discoidin_domain_receptor_2 / annexin_A2 / matrix_metalloproteinase_13 loop promotes joint_destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes .
17179173	0	matrix_metalloproteinase_13	36,63	interferon_gamma	100,116	matrix metalloproteinase 13	interferon gamma	4322	3458	Gene	Gene	expression|amod|START_ENTITY Inhibition|nmod|expression Inhibition|nmod|END_ENTITY	Inhibition of interleukin_1-induced matrix_metalloproteinase_13 expression in human chondrocytes by interferon_gamma .
24497499	0	matrix_metalloproteinase_13	59,86	nuclear_protein_1	31,48	matrix metalloproteinase 13	nuclear protein 1	4322	26471	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Brief report : stress-inducible nuclear_protein_1 regulates matrix_metalloproteinase_13 expression in human articular chondrocytes .
25639047	0	matrix_metalloproteinase_13	40,67	osteopontin	11,22	matrix metalloproteinase 13	osteopontin	4322	6696	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of osteopontin on expression of matrix_metalloproteinase_13 in human knee osteoarthritic chondrocytes -RSB- .
26722242	0	matrix_metalloproteinase_14	64,91	MicroRNA-133b	0,13	matrix metalloproteinase 14	MicroRNA-133b	4323	442890	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MicroRNA-133b inhibits cell migration and invasion by targeting matrix_metalloproteinase_14 in glioblastoma .
25767191	0	matrix_metalloproteinase_2	25,51	AT1R	103,107	matrix metalloproteinase 2	AT1R	4313	185	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|cells cells|nmod|END_ENTITY	Angiotensin_II increases matrix_metalloproteinase_2 expression in human aortic smooth muscle cells via AT1R and ERK1/2 .
25767191	0	matrix_metalloproteinase_2	25,51	Angiotensin_II	0,14	matrix metalloproteinase 2	Angiotensin II	4313	183	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases matrix_metalloproteinase_2 expression in human aortic smooth muscle cells via AT1R and ERK1/2 .
25380884	0	matrix_metalloproteinase_2	141,167	CCL2	197,201	matrix metalloproteinase 2	CCL2	4313	6347	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Advanced age of renal transplant recipients correlates with increased plasma concentrations of interleukin-6 , chemokine ligand 2 -LRB- CCL2 -RRB- , and matrix_metalloproteinase_2 , and urine concentrations of CCL2 and tissue inhibitor of metalloproteinase 1 .
22968857	0	matrix_metalloproteinase_2	23,49	ETV5	0,4	matrix metalloproteinase 2	ETV5	4313	2119	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	ETV5 as a regulator of matrix_metalloproteinase_2 in human chondrosarcoma .
12805379	0	matrix_metalloproteinase_2	47,73	K-ras	0,5	matrix metalloproteinase 2	K-ras	4313	3845	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	K-ras regulates the steady-state expression of matrix_metalloproteinase_2 in fibroblasts .
10433819	0	matrix_metalloproteinase_2	11,37	MMP-2	121,126	matrix metalloproteinase 2	MMP-2	17390(Tax:10090)	17390(Tax:10090)	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Diminished matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in ectomesenchyme-derived tissues of the Patch mutant mouse : regulation of MMP-2 by PDGF and effects on mesenchymal cell migration .
15167830	0	matrix_metalloproteinase_2	28,54	MMP-2	21,26	matrix metalloproteinase 2	MMP-2	4313	4313	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Comparative study of MMP-2 -LRB- matrix_metalloproteinase_2 -RRB- immune expression in normal uterine cervix , intraepithelial neoplasias , and squamous cells cervical_carcinoma .
23503864	0	matrix_metalloproteinase_2	51,77	MMP-2	79,84	matrix metalloproteinase 2	MMP-2	4313	4313	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Zimography is an effective method for detection of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- activity in cultured human fibroblasts .
11431697	0	matrix_metalloproteinase_2	16,42	MMP2	49,53	matrix metalloproteinase 2	MMP2	4313	4313	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation of the matrix_metalloproteinase_2 gene -LRB- MMP2 -RRB- causes a multicentric_osteolysis and arthritis_syndrome .
24637309	0	matrix_metalloproteinase_2	29,55	MMP2	57,61	matrix metalloproteinase 2	MMP2	4313	4313	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Patient with mutation in the matrix_metalloproteinase_2 -LRB- MMP2 -RRB- gene - a case report and review of the literature .
25317077	0	matrix_metalloproteinase_2	143,169	MT1-MMP	120,127	matrix metalloproteinase 2	MT1-MMP	4313	4323	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	High threshold of b1 integrin inhibition required to block collagen I-induced membrane type-1 matrix metalloproteinase -LRB- MT1-MMP -RRB- activation of matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- .
17650800	0	matrix_metalloproteinase_2	35,61	RelA	91,95	matrix metalloproteinase 2	RelA	81686(Tax:10116)	309165(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of curcumin on activity of matrix_metalloproteinase_2 , 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome_proliferator-activated_receptor_gamma signal -RSB- .
11592306	0	matrix_metalloproteinase_2	37,63	TGFbeta1	0,8	matrix metalloproteinase 2	TGFbeta1	4313	7040	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	TGFbeta1 stimulates the secretion of matrix_metalloproteinase_2 -LRB- MMP2 -RRB- and the invasive behavior in human ovarian_cancer cells , which is suppressed by MMP inhibitor BB3103 .
20717917	0	matrix_metalloproteinase_2	40,66	c-Cbl	0,5	matrix metalloproteinase 2	c-Cbl	4313	867	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	c-Cbl regulates glioma_invasion through matrix_metalloproteinase_2 .
14559821	0	matrix_metalloproteinase_2	116,142	extracellular_signal-regulated_kinase	151,188	matrix metalloproteinase 2	extracellular signal-regulated kinase	4313	5594	Gene	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix_metalloproteinase_2 via the extracellular_signal-regulated_kinase and p38 pathways .
12477525	0	matrix_metalloproteinase_2	35,61	gelatinase_A	21,33	matrix metalloproteinase 2	gelatinase A	81686(Tax:10116)	81686(Tax:10116)	Gene	Gene	induces|dep|START_ENTITY induces|dobj|END_ENTITY	Nitric_oxide induces gelatinase_A -LRB- matrix_metalloproteinase_2 -RRB- during rat embryo implantation .
12385578	0	matrix_metalloproteinase_3	33,59	MMP-3	61,66	matrix metalloproteinase 3	MMP-3	4314	4314	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The promoter polymorphism of the matrix_metalloproteinase_3 -LRB- MMP-3 -RRB- gene in women with ovarian_cancer .
17065356	0	matrix_metalloproteinase_3	27,53	MMP3	55,59	matrix metalloproteinase 3	MMP3	4314	4314	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of matrix_metalloproteinase_3 -LRB- MMP3 -RRB- in preadipocytes/stromal vascular cells from nonobese nondiabetic versus obese nondiabetic Pima Indians .
21224131	0	matrix_metalloproteinase_7	32,58	MMP-7	199,204	matrix metalloproteinase 7	MMP-7	4316	4316	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of recombinant human matrix_metalloproteinase_7 -LRB- Matrilysin -RRB- with potential role in tumor invasion by refolding from Escherichia_coli inclusion bodies and development of sandwich ELISA of MMP-7 .
19505922	0	matrix_metalloproteinase_7	28,54	cyclooxygenase_2	6,22	matrix metalloproteinase 7	cyclooxygenase 2	4316	5743	Gene	Gene	mRNA|amod|START_ENTITY END_ENTITY|nmod|mRNA	Fecal cyclooxygenase_2 plus matrix_metalloproteinase_7 mRNA assays as a marker for colorectal_cancer screening .
23508111	0	matrix_metalloproteinase_9	42,68	Brain-derived_neurotrophic_factor	0,33	matrix metalloproteinase 9	Brain-derived neurotrophic factor	81687(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor induces matrix_metalloproteinase_9 expression in neurons via the serum_response_factor / c-Fos pathway .
20578262	0	matrix_metalloproteinase_9	30,56	CD151	0,5	matrix metalloproteinase 9	CD151	4318	977	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	CD151 modulates expression of matrix_metalloproteinase_9 and promotes neoangiogenesis and progression of hepatocellular_carcinoma .
15180997	0	matrix_metalloproteinase_9	16,42	ERK1/2	90,96	matrix metalloproteinase 9	ERK1/2	4318	5595;5594	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Calcium-induced matrix_metalloproteinase_9 gene expression is differentially regulated by ERK1/2 and p38 MAPK in oral keratinocytes and oral_squamous_cell_carcinoma .
16512877	0	matrix_metalloproteinase_9	56,82	Extracellular_matrix_protein_1	0,30	matrix metalloproteinase 9	Extracellular matrix protein 1	4318	1893	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Extracellular_matrix_protein_1 inhibits the activity of matrix_metalloproteinase_9 through high-affinity protein/protein interactions .
10935492	0	matrix_metalloproteinase_9	30,56	MMP-9	58,63	matrix metalloproteinase 9	MMP-9	4318	4318	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Transcriptional inhibition of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity by a c-fos/estrogen _ receptor fusion protein is mediated by the proximal AP-1 site of the MMP-9 promoter and correlates with reduced tumor cell invasion .
11296850	0	matrix_metalloproteinase_9	29,55	MMP-9	57,62	matrix metalloproteinase 9	MMP-9	81687(Tax:10116)	81687(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Chronic vasodilation induces matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- expression during microvascular remodeling in rat skeletal muscle .
11531282	0	matrix_metalloproteinase_9	21,47	MMP-9	49,54	matrix metalloproteinase 9	MMP-9	4318	4318	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of latent matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- predicts survival in advanced ovarian_cancer .
16309207	0	matrix_metalloproteinase_9	13,39	MMP-9	41,46	matrix metalloproteinase 9	MMP-9	4318	4318	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- on the metastatic behavior of oropharyngeal_cancer .
16497166	0	matrix_metalloproteinase_9	45,71	MMP-9	73,78	matrix metalloproteinase 9	MMP-9	4318	4318	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of autocrine TNF-alpha-stimulated matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- expression by mitogen-activated protein kinases in THP-1 monocytic cells .
18777539	0	matrix_metalloproteinase_9	95,121	MMP-9	123,128	matrix metalloproteinase 9	MMP-9	4318	4318	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dynamic contrast-enhanced -LRB- DCE -RRB- derived transfer coefficient -LRB- ktrans -RRB- is a surrogate marker of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- expression in brain_tuberculomas .
18929380	0	matrix_metalloproteinase_9	23,49	MMP-9	51,56	matrix metalloproteinase 9	MMP-9	17395(Tax:10090)	17395(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Increased gelatinase_B / matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- activity in a murine model of acute coxsackievirus B4-induced pancreatitis .
24344026	0	matrix_metalloproteinase_9	17,43	MMP-9	45,50	matrix metalloproteinase 9	MMP-9	4318	4318	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Determination of matrix_metalloproteinase_9 -LRB- MMP-9 -RRB- protein expression in laryngeal_squamous_cell_carcinomas based on digital image analysis .
12830465	0	matrix_metalloproteinase_9	55,81	MMP9	83,87	matrix metalloproteinase 9	MMP9	4318	4318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of genetic variation and association in the matrix_metalloproteinase_9 -LRB- MMP9 -RRB- gene in ESRD patients .
25435928	0	matrix_metalloproteinase_9	91,117	Raf_kinase_inhibitor_protein	0,28	matrix metalloproteinase 9	Raf kinase inhibitor protein	4318	5037	Gene	Gene	downregulating|dobj|START_ENTITY inhibits|advcl|downregulating inhibits|nsubj|END_ENTITY	Raf_kinase_inhibitor_protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix_metalloproteinase_9 and upregulating tissue_inhibitor_of_metalloproteinase_4 expression .
16882662	0	matrix_metalloproteinase_9	22,48	c-Fos	82,87	matrix metalloproteinase 9	c-Fos	4318	2353	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|activation activation|nmod|END_ENTITY	Fibronectin increases matrix_metalloproteinase_9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol_3-kinase pathways in human lung_carcinoma cells .
20166242	0	matrix_metalloproteinase_9	157,183	cathepsin_B	96,107	matrix metalloproteinase 9	cathepsin B	4318	1508	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin_B and nuclear_factor_kappa_B-mediated induction of matrix_metalloproteinase_9 .
18954444	0	matrix_metalloproteinase_9	126,152	claudin_4	94,103	matrix metalloproteinase 9	claudin 4	4318	1364	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Serial analysis of gene expression of lobular_carcinoma_in_situ identifies down regulation of claudin_4 and overexpression of matrix_metalloproteinase_9 .
12443715	0	matrix_metalloproteinase_9	17,43	thrombospondin_1	47,63	matrix metalloproteinase 9	thrombospondin 1	4318	7057	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of matrix_metalloproteinase_9 by thrombospondin_1 in gastric_cancer .
8531010	0	matrix_metalloproteinase_matrilysin	14,49	MMP-7	51,56	matrix metalloproteinase matrilysin	MMP-7	4316	4316	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of matrix_metalloproteinase_matrilysin -LRB- MMP-7 -RRB- was induced by activated Ki-ras via AP-1 activation in SW1417 colon_cancer cells .
16251426	0	matrix_metalloproteinase_type_II	25,57	Angiotensin_II	0,14	matrix metalloproteinase type II	Angiotensin II	81686(Tax:10116)	24179(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Angiotensin_II activates matrix_metalloproteinase_type_II and mimics age-associated carotid arterial remodeling in young rats .
24372339	0	matrix_metalloproteinases	25,50	CD8	104,107	matrix metalloproteinases	CD8	4314	925	Gene	Gene	relationship|nmod|START_ENTITY relationship|dep|END_ENTITY	The relationship between matrix_metalloproteinases -LRB- MMP-3 , _ -8 , _ -9 -RRB- in serum and peripheral lymphocytes -LRB- CD8 -LRB- + -RRB- , CD56 -LRB- + -RRB- -RRB- in Down_syndrome children with gingivitis .
23983595	0	matrix_metalloproteinases_1_and_13	11,45	Prolidase	0,9	matrix metalloproteinases 1 and 13	Prolidase	4312;4322	5184	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Prolidase , matrix_metalloproteinases_1_and_13 activity , oxidative-antioxidative status as a marker of preterm premature rupture_of_membranes and chorioamnionitis in maternal vaginal washing fluids .
11042903	0	matrix_metalloproteinases_1_and_2	34,67	TIMP-2	131,137	matrix metalloproteinases 1 and 2	TIMP-2	4312;4313	7077	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of matrix_metalloproteinases_1_and_2 -LRB- MMP-1 and MMP-2 -RRB- and tissue inhibitor of metalloproteinase 2 -LRB- TIMP-2 -RRB- in ruptured and non-ruptured tubal ectopic pregnancies .
22471482	0	matrix_metalloproteinases_2_and_9	80,113	Platelet-derived_growth_factor-D	0,32	matrix metalloproteinases 2 and 9	Platelet-derived growth factor-D	4313;4318	80310	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Platelet-derived_growth_factor-D promotes ovarian_cancer invasion by regulating matrix_metalloproteinases_2_and_9 .
26440329	0	matrix_metalloproteinases_2_and_9	44,77	erbB2	204,209	matrix metalloproteinases 2 and 9	erbB2	282872(Tax:9913)	505709(Tax:9913)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Role of G protein-coupled receptors -LRB- GPCR -RRB- , matrix_metalloproteinases_2_and_9 -LRB- MMP2 and MMP9 -RRB- , heparin-binding_epidermal_growth_factor-like_growth_factor -LRB- hbEGF -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , erbB2 , and insulin-like_growth_factor_1_receptor -LRB- IGF-1R -RRB- in trenbolone_acetate-stimulated bovine satellite cell proliferation .
21437907	0	matrix_metalloproteinsase-2	50,77	MMP-2	79,84	matrix metalloproteinsase-2	MMP-2	4313	4313	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Endothelial cell microparticles act as centers of matrix_metalloproteinsase-2 -LRB- MMP-2 -RRB- activation and vascular matrix remodeling .
7853543	0	matrix_protein	32,46	M1	48,50	matrix protein	M1	100507027	100507027	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Nucleus-targeting domain of the matrix_protein -LRB- M1 -RRB- of influenza virus .
23417988	0	matrixmetalloproteinase-3_and_matrixmetalloproteinase-13	14,70	SUMO-2	74,80	matrixmetalloproteinase-3 and matrixmetalloproteinase-13	SUMO-2	4322	6613	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of matrixmetalloproteinase-3_and_matrixmetalloproteinase-13 by SUMO-2 / 3 through the transcription factor NF-kB .
20201372	0	max	92,95	C-myc	79,84	max	C-myc	4149	4609	Gene	Gene	p53|dep|START_ENTITY p53|compound|END_ENTITY	-LSB- Development of a set of diagnostic test systems for analysis of expression of C-myc , mad1 , max , p53 , and E2F1 gene oncomarkers by the reverse transcription reaction-polymerase chain reaction alignment technique -RSB- .
20201372	0	max	92,95	mad1	86,90	max	mad1	4149	4084	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	-LSB- Development of a set of diagnostic test systems for analysis of expression of C-myc , mad1 , max , p53 , and E2F1 gene oncomarkers by the reverse transcription reaction-polymerase chain reaction alignment technique -RSB- .
7520411	0	mb-1	36,40	CD79a	42,47	mb-1	CD79a	973	973	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of the B-cell marker mb-1 -LRB- CD79a -RRB- in Hodgkin 's _ disease .
16112196	0	mbl2	70,74	mannose-binding_lectin	41,63	mbl2	mannose-binding lectin	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Extra-hepatic transcription of the human mannose-binding_lectin gene -LRB- mbl2 -RRB- and the MBL-associated serine protease 1-3 genes .
24579967	0	mbl2	41,45	mannose-binding_lectin_2	15,39	mbl2	mannose-binding lectin 2	4153	4153	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of mannose-binding_lectin_2 -LRB- mbl2 -RRB- gene heterogeneity and its serum concentration with osteoporosis in postmenopausal women .
11459838	0	mch-r2	109,115	melanin-concentrating_hormone	69,98	mch-r2	melanin-concentrating hormone	84539	5367	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Identification and pharmacological characterization of a novel human melanin-concentrating_hormone receptor , mch-r2 .
18719002	0	mcl-1	18,23	Gastrin	0,7	mcl-1	Gastrin	4170	2520	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Gastrin increases mcl-1 expression in type I gastric_carcinoid tumors and a gastric epithelial cell line that expresses the CCK-2_receptor .
15792532	0	mcmklr1	34,41	chemerin_receptor	10,27	mcmklr1	chemerin receptor	14747(Tax:10090)	14747(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The mouse chemerin_receptor gene , mcmklr1 , utilizes alternative promoters for transcription and is regulated by all-trans_retinoic_acid .
10545463	0	mcp	4,7	bithorax_complex	49,65	mcp	bithorax complex	44013(Tax:7227)	42034(Tax:7227)	Gene	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	The mcp element from the Drosophila_melanogaster bithorax_complex mediates long-distance regulatory interactions .
9813227	0	mcp	48,51	major_capsid_protein	26,46	mcp	major capsid protein	4179	4179	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Cloning and sequencing of major_capsid_protein -LRB- mcp -RRB- gene of a vibriophage , KVP20 , possibly related to T-even coliphages .
15334067	0	mda-7	23,28	IL-24	29,34	mda-7	IL-24	11009	11009	Gene	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	Mechanistic aspects of mda-7 / IL-24 cancer cell selectivity analysed via a bacterial fusion protein .
16225913	0	mda-7	44,49	IL-24	50,55	mda-7	IL-24	11009	11009	Gene	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Ovarian_cancer targeted adenoviral-mediated mda-7 / IL-24 gene therapy .
18413837	0	mda-7	95,100	IL-24	101,106	mda-7	IL-24	11009	11009	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Treatment of cancer with a novel dual-targeted conditionally replicative adenovirus armed with mda-7 / IL-24 gene .
20179672	0	mda-7	82,87	IL-24	88,93	mda-7	IL-24	11009	11009	Gene	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Inhibition of multiple protective signaling pathways and Ad .5 / 3 delivery enhances mda-7 / IL-24 therapy of malignant_glioma .
20948318	0	mda-7	10,15	IL-24	16,21	mda-7	IL-24	11009	11009	Gene	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	Enhancing mda-7 / IL-24 therapy in renal_carcinoma_cells by inhibiting multiple protective signaling pathways using sorafenib and by Ad .5 / 3 gene delivery .
21732348	0	mda-7	0,5	IL-24	6,11	mda-7	IL-24	11009	11009	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	mda-7 / IL-24 differentially regulates soluble and nuclear clusterin in prostate_cancer .
22820863	0	mda-7	43,48	IL-24	49,54	mda-7	IL-24	93672(Tax:10090)	93672(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Conditionally replicative adenovirus-based mda-7 / IL-24 expression enhances sensitivity of colon_cancer cells to 5-fluorouracil and doxorubicin .
17308124	0	mda-9	0,5	Syntenin	6,14	mda-9	Syntenin	6386	6386	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	mda-9 / Syntenin regulates the metastatic phenotype in human melanoma cells by activating nuclear_factor-kappaB .
18832467	0	mda-9	0,5	Syntenin	6,14	mda-9	Syntenin	6386	6386	Gene	Gene	START_ENTITY|appos|promotes promotes|nsubj|END_ENTITY	mda-9 / Syntenin promotes metastasis in human melanoma cells by activating c-Src .
24434654	0	mdig	53,57	JNK	75,78	mdig	JNK	84864	5599	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation .
11353054	0	mdm-2	114,119	p21	98,101	mdm-2	p21	17246(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Transition from in situ to invasive testicular germ cell neoplasia is associated with the loss of p21 and gain of mdm-2 expression .
10392633	0	mdm-2	0,5	p53	43,46	mdm-2	p53	4193	7157	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|status status|compound|END_ENTITY	mdm-2 expression correlates with wild-type p53 status in esophageal_adenocarcinoma .
10951572	0	mdm-2	82,87	p53	108,111	mdm-2	p53	4193	7157	Gene	Gene	site|amod|START_ENTITY site|nmod|protein protein|compound|END_ENTITY	The human vaccinia-related_kinase_1 -LRB- VRK1 -RRB- phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein .
10963109	1	mdm-2	62,67	p53	57,60	mdm-2	p53	4193	7157	Gene	Gene	proteins|amod|START_ENTITY indices|nsubj|proteins indices|advcl|Correlation Correlation|nmod|END_ENTITY	Correlation with p53 , mdm-2 , Rb proteins and proliferation indices .
1535557	0	mdm-2	4,9	p53	52,55	mdm-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	product|amod|START_ENTITY forms|nsubj|product forms|nmod|protein protein|compound|END_ENTITY	The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation .
21556561	0	mdm-2	14,19	p53	88,91	mdm-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY Status|nmod|genes variants|nsubj|Status variants|xcomp|harboring harboring|dobj|END_ENTITY	Status of the mdm-2 and waf-1 genes in mouse epidermal jb6 variants harboring wild-type p53 - a p53-independent induction of waf-1 .
7646765	0	mdm-2	49,54	p53	0,3	mdm-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	amplification|amod|START_ENTITY loss|nmod|amplification mutation|nmod|loss mutation|nsubj|END_ENTITY	p53 mutation without allelic loss and absence of mdm-2 amplification in a transplantable hamster pancreatic_ductal_adenocarcinoma and derived cell lines but not primary ductal_adenocarcinomas in hamsters .
7926727	0	mdm-2	121,126	p53	39,42	mdm-2	p53	4193	7157	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|amino_acids amino_acids|nmod|domain domain|compound|END_ENTITY	Several hydrophobic amino_acids in the p53 amino-terminal domain are required for transcriptional activation , binding to mdm-2 and the adenovirus 5 E1B 55-kD protein .
8152809	0	mdm-2	4,9	p53	109,112	mdm-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	oncogene|amod|START_ENTITY translocated|nsubjpass|oncogene translocated|nmod|line line|acl|expressing expressing|dobj|END_ENTITY	The mdm-2 oncogene is translocated and overexpressed in a murine plasmacytoma cell line expressing wild-type p53 .
8361769	0	mdm-2	16,21	p53	76,79	mdm-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Upregulation|nmod|expression Upregulation|acl|tolerating tolerating|dobj|END_ENTITY	Upregulation of mdm-2 expression in Meth A_tumor cells tolerating wild-type p53 .
8417333	0	mdm-2	4,9	p53	42,45	mdm-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	oncogene|amod|START_ENTITY overcome|nsubj|oncogene overcome|dobj|suppression suppression|compound|END_ENTITY	The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth .
8529093	0	mdm-2	73,78	p53	45,48	mdm-2	p53	4193	7157	Gene	Gene	oncogene|amod|START_ENTITY Regulation|nmod|oncogene Regulation|nmod|suppressor suppressor|compound|END_ENTITY	Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene .
8649767	0	mdm-2	43,48	p53	30,33	mdm-2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	bound|xcomp|START_ENTITY bound|nsubj|Analysis Analysis|nmod|proportion proportion|nmod|END_ENTITY	Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics .
8747596	0	mdm-2	98,103	p53	33,36	mdm-2	p53	4193	7157	Gene	Gene	overexpression|amod|START_ENTITY associated|nmod|overexpression associated|nsubjpass|detection detection|nmod|END_ENTITY	Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression .
8747596	0	mdm-2	98,103	p53	60,63	mdm-2	p53	4193	7157	Gene	Gene	overexpression|amod|START_ENTITY associated|nmod|overexpression associated|nsubjpass|detection detection|nmod|p53 p53|nmod|melanomas melanomas|nmod|mutations mutations|compound|END_ENTITY	Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression .
8957072	0	mdm-2	48,53	p53	10,13	mdm-2	p53	4193	7157	Gene	Gene	gene|amod|START_ENTITY activate|dobj|gene unable|xcomp|activate unable|nsubj|protein protein|compound|END_ENTITY	Wild-type p53 protein is unable to activate the mdm-2 gene during F9 cell differentiation .
9150392	0	mdm-2	106,111	p53	38,41	mdm-2	p53	314856(Tax:10116)	301300(Tax:10116)	Gene	Gene	dependent|advcl|START_ENTITY transformed|xcomp|dependent transformed|nsubj|Tolerance Tolerance|nmod|levels levels|nmod|END_ENTITY	Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2 .
9291432	0	mdm-2	22,27	p53	53,56	mdm-2	p53	4193	7157	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|status status|compound|END_ENTITY	Altered expression of mdm-2 and its association with p53 protein status , tumor-cell-proliferation rate and prognosis in cervical neoplasia .
9688185	0	mdm-2	58,63	p53	53,56	mdm-2	p53	4193	7157	Gene	Gene	p21waf-1|amod|START_ENTITY E2F-1|amod|p21waf-1 E2F-1|appos|END_ENTITY	Expression of the cell-cycle-related proteins E2F-1 , p53 , mdm-2 , p21waf-1 , and Ki-67 in multiple myeloma : correlation with cyclin-D1 immunoreactivity .
9790068	0	mdm-2	14,19	p53	120,123	mdm-2	p53	4193	7157	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|dep|study study|nmod|expression expression|compound|END_ENTITY	Expression of mdm-2 protein in neoplastic , preneoplastic , and normal bronchial mucosa specimens : comparative study with p53 expression .
19062713	0	mdm2	22,26	Akt	17,20	mdm2	Akt	4193	207	Gene	Gene	START_ENTITY|nsubj|Impact Impact|dep|END_ENTITY	-LSB- Impact of PI3K / Akt / mdm2 signaling pathway on the sensitivity of gastric_cancer cell line SGC7901 to doxorubicin -RSB- .
26854347	0	mdm2	119,123	murine_double_minute_2	95,117	mdm2	murine double minute 2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The viral non-structural protein 1 alpha -LRB- Nsp1a -RRB- inhibits p53 apoptosis activity by increasing murine_double_minute_2 -LRB- mdm2 -RRB- expression in porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- early-infected cells .
17395400	0	mdm2	74,78	p14	59,62	mdm2	p14	4193	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
17395400	0	mdm2	74,78	p16	64,67	mdm2	p16	4193	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
11057904	0	mdm2	62,66	p19ARF	84,90	mdm2	p19ARF	4193	1029	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Opposing effects of Ras on p53 : transcriptional activation of mdm2 and induction of p19ARF .
17395400	0	mdm2	74,78	p21	49,52	mdm2	p21	4193	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
17395400	0	mdm2	74,78	p27	54,57	mdm2	p27	4193	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
10023338	0	mdm2	34,38	p53	97,100	mdm2	p53	4193	7157	Gene	Gene	expression|nmod|START_ENTITY expression|dep|correlation correlation|nmod|protein protein|compound|END_ENTITY	Immunohistochemical expression of mdm2 and p21WAF1 in invasive_cervical_cancer : correlation with p53 protein and high risk HPV infection .
10074928	0	mdm2	36,40	p53	90,93	mdm2	p53	4193	7157	Gene	Gene	transcripts|amod|START_ENTITY correlates|nsubj|transcripts correlates|nmod|protein protein|compound|END_ENTITY	Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells .
10432310	0	mdm2	114,118	p53	63,66	mdm2	p53	4193	7157	Gene	Gene	binding|nmod|START_ENTITY protein|amod|binding disrupt|dobj|protein END_ENTITY|acl:relcl|disrupt	Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 -LRB- mouse_double_minute_2 -RRB- protein are modified in human cancers .
10815906	0	mdm2	0,4	p53	94,97	mdm2	p53	4193	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|comparison comparison|nmod|overexpression overexpression|compound|END_ENTITY	mdm2 expression as a prognostic indicator in clear_cell_renal_cell_carcinoma : comparison with p53 overexpression and clinicopathological parameters .
11033015	0	mdm2	151,155	p53	113,116	mdm2	p53	4193	7157	Gene	Gene	protein|amod|START_ENTITY interactions|nmod|protein involved|nmod|interactions residues|acl|involved residues|nmod|END_ENTITY	Critical residues of epitopes recognized by several anti-p53 monoclonal antibodies correspond to key residues of p53 involved in interactions with the mdm2 protein .
11057904	0	mdm2	62,66	p53	27,30	mdm2	p53	4193	7157	Gene	Gene	activation|nmod|START_ENTITY effects|dep|activation effects|nmod|END_ENTITY	Opposing effects of Ras on p53 : transcriptional activation of mdm2 and induction of p19ARF .
11173581	0	mdm2	21,25	p53	54,57	mdm2	p53	4193	7157	Gene	Gene	MIB1|dep|START_ENTITY Proliferative|appos|MIB1 Versus|nsubj|Proliferative Versus|dobj|Markers Markers|appos|END_ENTITY	Proliferative -LRB- MIB1 , mdm2 -RRB- Versus Anti-Proliferative -LRB- p53 -RRB- Markers in Head_and_Neck_Cancer .
11240753	0	mdm2	128,132	p53	47,50	mdm2	p53	4193	7157	Gene	Gene	correlation|nmod|START_ENTITY analysis|dep|correlation analysis|nmod|gene gene|compound|END_ENTITY	Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational_trophoblastic_disease : correlation with mdm2 , proliferation index , and clinicopathologic parameters .
11240767	0	mdm2	36,40	p53	31,34	mdm2	p53	4193	7157	Gene	Gene	c-erbB-2|amod|START_ENTITY significance|amod|c-erbB-2 significance|nmod|END_ENTITY	The prognostic significance of p53 , mdm2 , c-erbB-2 , cathepsin_D , and thrombocytosis in stage_IB_cervical_cancer treated by primary radical hysterectomy .
11397792	0	mdm2	6,10	p53	52,55	mdm2	p53	4193	7157	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|mono-ubiquitination mono-ubiquitination|nmod|END_ENTITY	Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization .
12138177	0	mdm2	34,38	p53	51,54	mdm2	p53	4193	7157	Gene	Gene	oncogene|amod|START_ENTITY oncogene|nmod|END_ENTITY	Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes .
12509446	0	mdm2	0,4	p53	35,38	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	critical|nsubj|START_ENTITY critical|nmod|inhibition inhibition|nmod|END_ENTITY	mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation .
14555661	0	mdm2	121,125	p53	10,13	mdm2	p53	4193	7157	Gene	Gene	amplification|amod|START_ENTITY required|nmod|amplification required|nsubj|modification modification|compound|END_ENTITY	Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification .
14555661	0	mdm2	121,125	p53	69,72	mdm2	p53	4193	7157	Gene	Gene	amplification|amod|START_ENTITY required|nmod|amplification required|nmod|inactivation inactivation|compound|END_ENTITY	Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification .
14695178	0	mdm2	38,42	p53	78,81	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	death|nmod|START_ENTITY mechanisms|nmod|death Switching|dobj|mechanisms Switching|nmod|deletion deletion|nmod|targets targets|nummod|END_ENTITY	Switching mechanisms of cell death in mdm2 - and mdm4-null mice by deletion of p53 downstream targets .
15361844	0	mdm2	70,74	p53	12,15	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY embryonic_lethality|nmod|mice rescue|dobj|embryonic_lethality rescue|nsubj|Mutation Mutation|nmod|389 389|compound|END_ENTITY	Mutation at p53 serine 389 does not rescue the embryonic_lethality in mdm2 or mdm4 null mice .
16470212	0	mdm2	81,85	p53	124,127	mdm2	p53	4193	7157	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2 - and E1b-55kD-mediated degradation of p53 .
16470212	0	mdm2	81,85	p53	20,23	mdm2	p53	4193	7157	Gene	Gene	degradation|amod|START_ENTITY prevents|dobj|degradation prevents|nsubj|Modification Modification|nmod|transgene transgene|compound|END_ENTITY	Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2 - and E1b-55kD-mediated degradation of p53 .
16696089	1	mdm2	108,112	p53	87,90	mdm2	p53	4193	7157	Gene	Gene	induced|xcomp|START_ENTITY induced|nsubj|study study|nmod|END_ENTITY	Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1 .
17395400	0	mdm2	74,78	p53	69,72	mdm2	p53	4193	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
17989425	0	mdm2	66,70	p53	53,56	mdm2	p53	4193	7157	Gene	Gene	measuring|nmod|START_ENTITY measuring|dobj|ubiquitination ubiquitination|nmod|END_ENTITY	A high-throughput screen measuring ubiquitination of p53 by human mdm2 .
18852133	0	mdm2	77,81	p53	38,41	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	down-regulation|nmod|START_ENTITY apoptosis|nmod|down-regulation apoptosis|nmod|inducer inducer|compound|END_ENTITY	Gambogic_acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells .
22787160	0	mdm2	41,45	p53	70,73	mdm2	p53	4193	7157	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Transcription factor NFAT1 activates the mdm2 oncogene independent of p53 .
23416275	0	mdm2	44,48	p53	14,17	mdm2	p53	4193	7157	Gene	Gene	p14ARF|compound|START_ENTITY acetylation|nmod|p14ARF acetylation|nsubj|Modulation Modulation|nmod|C-terminal C-terminal|compound|END_ENTITY	Modulation of p53 C-terminal acetylation by mdm2 , p14ARF , and cytoplasmic SirT2 .
25746004	0	mdm2	93,97	p53	28,31	mdm2	p53	30637(Tax:7955)	30590(Tax:7955)	Gene	Gene	insights|nmod|START_ENTITY inactivation|dep|insights mimicked|nmod|inactivation mimicked|nsubjpass|Tumor-specific Tumor-specific|acl|signaling signaling|nmod|END_ENTITY	Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish : insights from mdm2 and mdm4 mutant zebrafish .
26416444	0	mdm2	11,15	p53	83,86	mdm2	p53	4193	7157	Gene	Gene	cells|amod|START_ENTITY cells|nmod|elongation elongation|nmod|genes genes|compound|END_ENTITY	Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death .
26854347	0	mdm2	119,123	p53	58,61	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY increasing|iobj|expression inhibits|advcl|increasing inhibits|dobj|activity activity|compound|END_ENTITY	The viral non-structural protein 1 alpha -LRB- Nsp1a -RRB- inhibits p53 apoptosis activity by increasing murine_double_minute_2 -LRB- mdm2 -RRB- expression in porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- early-infected cells .
7551299	0	mdm2	0,4	p53	102,105	mdm2	p53	4193	7157	Gene	Gene	amplification|amod|START_ENTITY amplification|nmod|protein protein|compound|END_ENTITY	mdm2 gene amplification and overexpression in non-small_cell_lung_carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations .
7551299	0	mdm2	0,4	p53	132,135	mdm2	p53	4193	7157	Gene	Gene	amplification|amod|START_ENTITY amplification|nmod|absence absence|nmod|mutations mutations|compound|END_ENTITY	mdm2 gene amplification and overexpression in non-small_cell_lung_carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations .
7663443	0	mdm2	32,36	p53	141,144	mdm2	p53	4193	7157	Gene	Gene	markedly|nmod:npmod|START_ENTITY increases|advmod|markedly increases|xcomp|carbon_tetrachloride carbon_tetrachloride|dep|not not|nmod|END_ENTITY	Expression of the protooncogene mdm2 markedly increases in response to carbon_tetrachloride but not after partial hepatectomy in contrast to p53 .
7753547	0	mdm2	71,75	p53	31,34	mdm2	p53	4193	7157	Gene	Gene	interaction|nmod|START_ENTITY contributes|nmod|interaction contributes|nsubj|Oligomerisation Oligomerisation|nmod|END_ENTITY	Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6 .
7958853	0	mdm2	14,18	p53	33,36	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of mdm2 expression by p53 : alternative promoters produce transcripts with nonidentical translation potential .
8247544	0	mdm2	95,99	p53	10,13	mdm2	p53	4193	7157	Gene	Gene	gene|amod|START_ENTITY mediate|nmod|gene mediate|nsubj|END_ENTITY	Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene .
8280379	0	mdm2	97,101	p53	15,18	mdm2	p53	4193	7157	Gene	Gene	amplification|amod|START_ENTITY Correlation|nmod|amplification Correlation|nmod|mutations mutations|compound|END_ENTITY	Correlation of p53 mutations with epidermal_growth_factor_receptor overexpression and absence of mdm2 amplification in human esophageal_carcinomas .
8440237	0	mdm2	0,4	p53	40,43	mdm2	p53	4193	7157	Gene	Gene	expression|amod|START_ENTITY induced|nsubjpass|expression induced|nmod|activity activity|compound|END_ENTITY	mdm2 expression is induced by wild type p53 activity .
8705862	0	mdm2	22,26	p53	52,55	mdm2	p53	4193	7157	Gene	Gene	transcripts|amod|START_ENTITY transcripts|nmod|loss loss|nmod|sequences sequences|nummod|END_ENTITY	Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences : transforming ability and frequent detection in human cancer .
9029163	0	mdm2	28,32	p53	0,3	mdm2	p53	314856(Tax:10116)	301300(Tax:10116)	Gene	Gene	amplification|amod|START_ENTITY mutation|nmod|amplification mutation|compound|END_ENTITY	p53 mutation and absence of mdm2 amplification and Ki-ras mutation in 4-hydroxyamino_quinoline_1-oxide induced transplantable osteosarcomas in rats .
9216675	1	mdm2	103,107	p53	82,85	mdm2	p53	4193	7157	Gene	Gene	induced|xcomp|START_ENTITY induced|nsubj|study study|nmod|END_ENTITY	Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1 .
9270029	0	mdm2	29,33	p53	109,112	mdm2	p53	4193	7157	Gene	Gene	expression|amod|START_ENTITY enhancement|nmod|expression enhancement|acl|containing containing|dobj|protein protein|compound|END_ENTITY	Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein .
9380404	0	mdm2	16,20	p53	4,7	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY targets|ccomp|required targets|nsubj|END_ENTITY	The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo .
9438391	0	mdm2	0,4	p53	42,45	mdm2	p53	4193	7157	Gene	Gene	START_ENTITY|appos|mediators mediators|nmod|response response|compound|END_ENTITY	mdm2 and bax , downstream mediators of the p53 response , are degraded by the ubiquitin-proteasome pathway .
9486848	0	mdm2	44,48	p53	57,60	mdm2	p53	4193	7157	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of transcriptional activation of mdm2 gene by p53 in response to UV radiation .
9528859	0	mdm2	60,64	p53	0,3	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY region|nmod|gene binds|nmod|region binds|nsubj|END_ENTITY	p53 binds to a constitutively nucleosome free region of the mdm2 gene .
9645455	0	mdm2	22,26	p53	72,75	mdm2	p53	4193	7157	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene related|nsubjpass|expression related|nmod|aberration aberration|nmod|gene gene|compound|END_ENTITY	The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular_carcinoma .
9649502	0	mdm2	34,38	p53	74,77	mdm2	p53	17246(Tax:10090)	22060(Tax:10090)	Gene	Gene	loop|amod|START_ENTITY Suppression|nmod|loop induces|nsubj|Suppression induces|dobj|function function|compound|END_ENTITY	Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function .
9681831	0	mdm2	103,107	p53	87,90	mdm2	p53	4193	7157	Gene	Gene	dependent|nmod|START_ENTITY dependent|nmod|regulation regulation|nmod|function function|compound|END_ENTITY	The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2 .
12416559	0	mdm2	18,22	progesterone_receptor	52,73	mdm2	progesterone receptor	4193	5241	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Overexpression of mdm2 and p53 and association with progesterone_receptor expression in benign_meningiomas .
12036937	0	mdmx	0,4	p53	32,35	mdmx	p53	17248(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|activity activity|compound|END_ENTITY	mdmx is a negative regulator of p53 activity in vivo .
9378810	0	mdr-1	6,11	P-170	20,25	mdr-1	P-170	18669(Tax:10090)	18704(Tax:10090)	Gene	Gene	antibody|amod|START_ENTITY antibody|compound|END_ENTITY	A new mdr-1 encoded P-170 specific monoclonal antibody : -LRB- 6/1C -RRB- on paraffin wax embedded tissue without pretreatment of sections .
1678252	0	mdr-1	14,19	P-glycoprotein	20,34	mdr-1	P-glycoprotein	5243	5243	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of mdr-1 / P-glycoprotein in human neuroblastoma .
8094079	0	mdr-1	10,15	P-glycoprotein	16,30	mdr-1	P-glycoprotein	5243	5243	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Increased mdr-1 / P-glycoprotein expression after treatment of human colon_carcinoma cells with P-glycoprotein antagonists .
9719458	0	mdr-1	20,25	WT1	45,48	mdr-1	WT1	5243	7490	Gene	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines .
11096091	1	mdr1	124,128	AhR	36,39	mdr1	AhR	110357(Tax:10090)	11622(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	AhR nuclear translocator - and p53-mediated induction of the murine multidrug resistance mdr1 gene by 3-methylcholanthrene and benzo -LRB- a -RRB- pyrene in hepatoma cells .
2876781	0	mdr1	75,79	P-glycoprotein	81,95	mdr1	P-glycoprotein	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Internal duplication and homology with bacterial_transport_proteins in the mdr1 -LRB- P-glycoprotein -RRB- gene from multidrug-resistant human cells .
2897240	0	mdr1	116,120	P-glycoprotein	122,136	mdr1	P-glycoprotein	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 -LRB- P-glycoprotein -RRB- gene .
7654329	0	mdr1	18,22	P-glycoprotein	23,37	mdr1	P-glycoprotein	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Expression of the mdr1 P-glycoprotein gene : a mechanism of escape from glucocorticoid-induced apoptosis .
9333100	0	mdr1	35,39	P-glycoprotein	19,33	mdr1	P-glycoprotein	5243	5243	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of intestinal P-glycoprotein -LRB- mdr1 -RRB- in interpatient variation in the oral bioavailability of cyclosporine .
9558371	0	mdr1	128,132	P-glycoprotein	14,28	mdr1	P-glycoprotein	5243	5243	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of P-glycoprotein and recovery of drug sensitivity of human acute leukemic blast cells by multidrug resistance gene -LRB- mdr1 -RRB- antisense oligonucleotides .
7875611	0	mdr1	10,14	multidrug-resistance	16,36	mdr1	multidrug-resistance	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	The human mdr1 -LRB- multidrug-resistance -RRB- gene harbours a long homopyrimidine.homopurine sequence next to a cluster of Alu repeated sequences in intron 14 .
8587143	0	mdr1	68,72	multidrug_resistance	74,94	mdr1	multidrug resistance	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Repetitive DNA sequences located in the central region of the human mdr1 -LRB- multidrug_resistance -RRB- gene may account for a gene fusion event during its evolution .
21584513	0	mdr1	48,52	multidrug_resistance-1	24,46	mdr1	multidrug resistance-1	5243	5243	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Activation of the human multidrug_resistance-1 -LRB- mdr1 -RRB- gene promoter in response to inhibitors of DNA topoisomerases .
12475404	0	mdr1	66,70	multidrug_resistance-associated_protein	78,117	mdr1	multidrug resistance-associated protein	5243	8714	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Correlation of expression levels of multidrug_resistance_gene_1 -LRB- mdr1 -RRB- mRNA , multidrug_resistance-associated_protein -LRB- MRP -RRB- , amd P-glycoprotein -LRB- P-gp -RRB- with chemotherapy efficacy in malignant_lymphomas -RSB- .
12475404	0	mdr1	66,70	multidrug_resistance_gene_1	37,64	mdr1	multidrug resistance gene 1	5243	5243	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Correlation of expression levels of multidrug_resistance_gene_1 -LRB- mdr1 -RRB- mRNA , multidrug_resistance-associated_protein -LRB- MRP -RRB- , amd P-glycoprotein -LRB- P-gp -RRB- with chemotherapy efficacy in malignant_lymphomas -RSB- .
17237282	0	mdr1	64,68	tumor_necrosis_factor-alpha	88,115	mdr1	tumor necrosis factor-alpha	5243	7124	Gene	Gene	colon_carcinoma|nmod|START_ENTITY therapy|nmod|colon_carcinoma Heat-inducible|nmod|therapy promoter-regulated|nsubj|Heat-inducible promoter-regulated|dobj|expression expression|amod|END_ENTITY	Heat-inducible in vivo gene therapy of colon_carcinoma by human mdr1 promoter-regulated tumor_necrosis_factor-alpha expression .
14501258	0	mdr1a	149,154	P-Glycoprotein	0,14	mdr1a	P-Glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	using|xcomp|START_ENTITY study|acl|using reduces|parataxis|study reduces|nsubj|efflux efflux|amod|END_ENTITY	P-Glycoprotein efflux reduces the brain concentration of the substance_P -LRB- NK1_receptor -RRB- antagonists SR140333 and GR205171 : a comparative study using mdr1a - / - and mdr1a + / + mice .
14501258	0	mdr1a	162,167	P-Glycoprotein	0,14	mdr1a	P-Glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	+|amod|START_ENTITY /|dep|+ mdr1a|dep|/ using|xcomp|mdr1a study|acl|using reduces|parataxis|study reduces|nsubj|efflux efflux|amod|END_ENTITY	P-Glycoprotein efflux reduces the brain concentration of the substance_P -LRB- NK1_receptor -RRB- antagonists SR140333 and GR205171 : a comparative study using mdr1a - / - and mdr1a + / + mice .
10516633	0	mdr1a	112,117	P-glycoprotein	12,26	mdr1a	P-glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY studies|nmod|mice role|dep|studies role|nmod|END_ENTITY	The role of P-glycoprotein in blood-brain barrier transport of morphine : transcortical microdialysis studies in mdr1a -LRB- - / - -RRB- and mdr1a -LRB- + / + -RRB- mice .
11496955	0	mdr1a	10,15	P-glycoprotein	16,30	mdr1a	P-glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	disruption|amod|START_ENTITY disruption|amod|END_ENTITY	Effect of mdr1a P-glycoprotein gene disruption , gender , and substrate concentration on brain uptake of selected compounds .
11959808	0	mdr1a	111,116	P-glycoprotein	14,28	mdr1a	P-glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY using|nmod|mice permeability|xcomp|using permeability|nsubj|Resolution Resolution|nmod|effects effects|amod|END_ENTITY	Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a -LRB- - / - -RRB- mice .
12807720	0	mdr1a	70,75	P-glycoprotein	12,26	mdr1a	P-glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	formation|amod|START_ENTITY disruption|nmod|formation role|dep|disruption role|nmod|END_ENTITY	The role of P-glycoprotein in intestinal tumorigenesis : disruption of mdr1a suppresses polyp formation in Apc -LRB- Min / + -RRB- mice .
24985475	0	mdr1a	128,133	P-glycoprotein	10,24	mdr1a	P-glycoprotein	170913(Tax:10116)	287115(Tax:10116)	Gene	Gene	rats|amod|START_ENTITY using|dobj|rats comparison|acl|using Impact|dep|comparison Impact|nmod|END_ENTITY	Impact of P-glycoprotein on blood-retinal barrier permeability : comparison of blood-aqueous_humor and blood-brain barrier using mdr1a knockout rats .
7910522	0	mdr1a	24,29	P-glycoprotein	30,44	mdr1a	P-glycoprotein	18671(Tax:10090)	5243	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency_in_the_blood-brain barrier and to increased sensitivity to drugs .
10661503	0	mdr1a	14,19	p-glycoprotein	20,34	mdr1a	p-glycoprotein	18671(Tax:10090)	67078(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice .
1381362	0	mdr2	0,4	P-glycoprotein	13,27	mdr2	P-glycoprotein	5244	5243	Gene	Gene	encodes|nsubj|START_ENTITY encodes|ccomp|expressed expressed|nsubj|END_ENTITY	mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies .
7977654	0	mdr2	39,43	P-glycoprotein	44,58	mdr2	P-glycoprotein	18670(Tax:10090)	5243	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Mice with homozygous disruption of the mdr2 P-glycoprotein gene .
9020871	0	mdr2	14,18	P-glycoprotein	19,33	mdr2	P-glycoprotein	18670(Tax:10090)	67078(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of mdr2 P-glycoprotein expression by bile_salts .
18772608	0	mechano_growth_factor	26,47	Growth_hormone	0,14	mechano growth factor	Growth hormone	17311(Tax:10090)	14599(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Growth_hormone stimulates mechano_growth_factor expression and activates myoblast transformation in C2C12 cells .
15308683	0	mechano_growth_factor	7,28	growth_hormone	58,72	mechano growth factor	growth hormone	17311(Tax:10090)	14599(Tax:10090)	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Muscle mechano_growth_factor is preferentially induced by growth_hormone in growth_hormone-deficient lit/lit mice .
17151237	0	med-1	29,34	med-2	35,40	med-1	med-2	191705(Tax:6239)	191706(Tax:6239)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Neither maternal nor zygotic med-1 / med-2 genes play a major role in specifying the Caenorhabditis_elegans endoderm .
17151237	0	med-2	35,40	med-1	29,34	med-2	med-1	191706(Tax:6239)	191705(Tax:6239)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Neither maternal nor zygotic med-1 / med-2 genes play a major role in specifying the Caenorhabditis_elegans endoderm .
21454576	0	mediator_subunit_1	54,72	Arginine_and_glutamate-rich_1	0,29	mediator subunit 1	Arginine and glutamate-rich 1	5469	55082;157697	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Arginine_and_glutamate-rich_1 -LRB- ARGLU1 -RRB- interacts with mediator_subunit_1 -LRB- MED1 -RRB- and is required for estrogen_receptor-mediated gene transcription and breast_cancer cell growth .
1684086	0	medium-chain_Acyl-CoA_dehydrogenase	119,154	MCAD	156,160	medium-chain Acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular survey of a prevalent mutation , 985A-to-G transition , and identification of five infrequent mutations in the medium-chain_Acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in 55 patients with MCAD_deficiency .
10463467	0	medium-chain_acyl-CoA_dehydrogenase	41,76	MCAD	78,82	medium-chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prevalence of the 985A > G mutation in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in Sweden .
19551636	0	medium-chain_acyl-CoA_dehydrogenase	32,67	MCAD	69,73	medium-chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A985G mutation incidence in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in Brazil .
8099254	0	medium-chain_acyl-CoA_dehydrogenase	78,113	MCAD	115,119	medium-chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Three RFLPs defining a haplotype associated with the common mutation in human medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- deficiency occur in Alu repeats .
8102510	0	medium-chain_acyl-CoA_dehydrogenase	42,77	MCAD	79,83	medium-chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A rare disease-associated mutation in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene changes a conserved arginine , previously shown to be functionally essential in short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- .
8127075	0	medium-chain_acyl-CoA_dehydrogenase	54,89	MCAD	91,95	medium-chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Scottish frequency of the common G985 mutation in the medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene and the role of MCAD_deficiency in sudden_infant_death_syndrome -LRB- SIDS -RRB- .
8590228	0	medium-chain_acyl-CoA_dehydrogenase	36,71	MCAD	73,77	medium-chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Screening of A985_to_G mutation of medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene in Normandy .
8682492	0	medium-chain_acyl-CoA_dehydrogenase	42,77	MCAD	79,83	medium-chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Prevalence of carriers of the most common medium-chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- deficiency mutation -LRB- G985A -RRB- in The Netherlands .
11400780	0	medium-chain_acyl_CoA_dehydrogenase	29,64	MCAD	66,70	medium-chain acyl CoA dehydrogenase	MCAD	34	34	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Screening of the most common medium-chain_acyl_CoA_dehydrogenase -LRB- MCAD -RRB- deficiency mutation -LRB- K329E -RRB- in the Czech newborn population .
8314750	0	medium_chain_acyl-CoA_dehydrogenase	38,73	Hepatocyte_nuclear_factor-4	0,27	medium chain acyl-CoA dehydrogenase	Hepatocyte nuclear factor-4	24158(Tax:10116)	25735(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Hepatocyte_nuclear_factor-4 activates medium_chain_acyl-CoA_dehydrogenase gene transcription by interacting with a complex regulatory element .
1363805	0	medium_chain_acyl-CoA_dehydrogenase	17,52	MCAD	54,58	medium chain acyl-CoA dehydrogenase	MCAD	34	34	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the medium_chain_acyl-CoA_dehydrogenase -LRB- MCAD -RRB- gene .
3748657	0	medium_chain_acyl-CoA_dehydrogenase	103,138	medium_chain_acyl-CoA_dehydrogenase	24,59	medium chain acyl-CoA dehydrogenase	medium chain acyl-CoA dehydrogenase	34	34	Gene	Gene	deficiency|amod|START_ENTITY patients|nmod|deficiency END_ENTITY|nmod|patients	Biosynthesis of variant medium_chain_acyl-CoA_dehydrogenase in cultured fibroblasts from patients with medium_chain_acyl-CoA_dehydrogenase deficiency .
3748657	0	medium_chain_acyl-CoA_dehydrogenase	24,59	medium_chain_acyl-CoA_dehydrogenase	103,138	medium chain acyl-CoA dehydrogenase	medium chain acyl-CoA dehydrogenase	34	34	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|deficiency deficiency|amod|END_ENTITY	Biosynthesis of variant medium_chain_acyl-CoA_dehydrogenase in cultured fibroblasts from patients with medium_chain_acyl-CoA_dehydrogenase deficiency .
2322278	0	medullasin	56,66	human_leukocyte_elastase	25,49	medullasin	human leukocyte elastase	1991	1991	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Functional expression of human_leukocyte_elastase -LRB- HLE -RRB- / medullasin in eukaryotic cells .
17574232	0	mef2ca	0,6	Endothelin1	53,64	mef2ca	Endothelin1	30575(Tax:7955)	58032(Tax:7955)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish .
3935881	0	megakaryocyte_colony_stimulating_factor	7,46	interleukin_3	68,81	megakaryocyte colony stimulating factor	interleukin 3	21832(Tax:10090)	16187(Tax:10090)	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Murine megakaryocyte_colony_stimulating_factor : its relationship to interleukin_3 .
7822271	0	megakaryocyte_growth_and_development_factor	42,85	MGDF	87,91	megakaryocyte growth and development factor	MGDF	7066	7066	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of the human megakaryocyte_growth_and_development_factor -LRB- MGDF -RRB- gene .
8948024	0	megakaryocyte_growth_and_development_factor	34,77	MPL	29,32	megakaryocyte growth and development factor	MPL	7066	4352	Gene	Gene	ligand|appos|START_ENTITY ligand|nmod|END_ENTITY	Recombinant human ligand for MPL , megakaryocyte_growth_and_development_factor -LRB- MGDF -RRB- , stimulates thrombopoiesis in vivo in normal and myelosuppressed baboons .
7542117	0	megakaryocyte_growth_and_development_factor	18,61	c-Mpl	86,91	megakaryocyte growth and development factor	c-Mpl	7066	4352	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|END_ENTITY	Recombinant human megakaryocyte_growth_and_development_factor -LRB- rHuMGDF -RRB- , a ligand for c-Mpl , produces functional human platelets in vitro .
10458926	0	megakaryocyte_growth_and_development_factor	11,54	thrombopoietin	56,70	megakaryocyte growth and development factor	thrombopoietin	21832(Tax:10090)	21832(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of megakaryocyte_growth_and_development_factor -LRB- thrombopoietin -RRB- on liver endothelial cells in vitro .
9678719	0	megakaryocyte_growth_and_development_factor	12,55	thrombopoietin	57,71	megakaryocyte growth and development factor	thrombopoietin	7066	7066	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of megakaryocyte_growth_and_development_factor -LRB- thrombopoietin -RRB- effects on blast cell and megakaryocyte growth in myelodysplasia .
23836931	0	megalin	12,19	ARH	0,3	megalin	ARH	4036	26119	Gene	Gene	directs|dobj|START_ENTITY directs|nsubj|END_ENTITY	ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression .
16828734	0	megalin	12,19	Gp330	27,32	megalin	Gp330	4036	4036	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of megalin -LRB- LRP-2 / Gp330 -RRB- during development .
11274227	0	megalin	62,69	MAGI-1	49,55	megalin	MAGI-1	14725(Tax:10090)	14924(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes .
12508107	0	megalin	26,33	MegBP	67,72	megalin	MegBP	4036	55805	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|END_ENTITY	Functional interaction of megalin with the megalinbinding protein -LRB- MegBP -RRB- , a novel tetratrico peptide repeat-containing adaptor molecule .
10364184	0	megalin	24,31	NHE3	65,69	megalin	NHE3	4036	6550	Gene	Gene	association|nmod|START_ENTITY association|dep|END_ENTITY	Specific association of megalin and the Na + / H + exchanger isoform NHE3 in the proximal tubule .
22617749	0	megalin	8,15	RAP	51,54	megalin	RAP	14725(Tax:10090)	16976(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo .
27094046	0	megalin	159,166	RAP	116,119	megalin	RAP	14725(Tax:10090)	16976(Tax:10090)	Gene	Gene	due|xcomp|START_ENTITY due|nsubj|retention retention|nmod|protein protein|appos|END_ENTITY	Intracellular retention of thyroglobulin in the absence of the low-density lipoprotein receptor-associated protein -LRB- RAP -RRB- is likely due to premature binding to megalin in the biosynthetic pathway .
24740791	0	megalin	139,146	angiotensin_II	47,61	megalin	angiotensin II	29216(Tax:10116)	24179(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY Mechanisms|dep|role Mechanisms|nmod|uptake uptake|nmod|END_ENTITY	Mechanisms of AT1a receptor-mediated uptake of angiotensin_II by proximal tubule cells : a novel role of the multiligand endocytic receptor megalin .
7544804	0	megalin	42,49	glycoprotein_330	25,41	megalin	glycoprotein 330	4036	4036	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Evidence that epithelial glycoprotein_330 / megalin mediates uptake of polybasic drugs .
10702280	0	megalin	8,15	gp330	17,22	megalin	gp330	29216(Tax:10116)	29216(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of megalin -LRB- gp330 -RRB- in transcytosis of thyroglobulin by thyroid cells .
16306401	0	megalin	15,22	insulin-like_growth_factor_I	63,91	megalin	insulin-like growth factor I	4036	3479	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Choroid plexus megalin is involved in neuroprotection by serum insulin-like_growth_factor_I .
10026171	0	megalin	69,76	seminal_vesicle_secretory_protein_II	106,142	megalin	seminal vesicle secretory protein II	29216(Tax:10116)	25013(Tax:10116)	Gene	Gene	START_ENTITY|nmod|receptor receptor|nmod|END_ENTITY	Identification of low_density_lipoprotein_receptor-related_protein-2 / megalin as an endocytic receptor for seminal_vesicle_secretory_protein_II .
15579681	0	mei5	18,22	dmc1	59,63	mei5	dmc1	855982(Tax:4932)	856926(Tax:4932)	Gene	Gene	act|nsubj|START_ENTITY act|nmod|END_ENTITY	The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination .
15215198	0	meichroacidin	10,23	MSAP	0,4	meichroacidin	MSAP	22092(Tax:10090)	66902(Tax:10090)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	MSAP , the meichroacidin homolog of carp -LRB- Cyprinus_carpio -RRB- , differs from the rodent counterpart in germline expression and involves flagellar differentiation .
24448023	0	meis1	70,75	MiR-144	0,7	meis1	MiR-144	170446(Tax:7955)	100033668(Tax:7955)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-144 regulates hematopoiesis and vascular development by targeting meis1 during zebrafish development .
18216175	0	meis1	0,5	cyclin_D1	16,25	meis1	cyclin D1	170446(Tax:7955)	30222(Tax:7955)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	meis1 regulates cyclin_D1 and c-myc expression , and controls the proliferation of the multipotent cells in the early developing zebrafish eye .
24809472	0	meis1	66,71	hoxa9	73,78	meis1	hoxa9	17268(Tax:10090)	15405(Tax:10090)	Gene	Gene	onset|nmod|START_ENTITY onset|dep|leukemogenesis leukemogenesis|amod|END_ENTITY	The deficiency of tumor suppressor prep1 accelerates the onset of meis1 - hoxa9 leukemogenesis .
9706977	0	melan-A	14,21	MART1	23,28	melan-A	MART1	2315	2315	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of melan-A -LRB- MART1 -RRB- in benign_melanocytic_nevi and primary cutaneous_malignant_melanoma .
10071774	0	melanin-concentrating_hormone	69,98	MCH	100,103	melanin-concentrating hormone	MCH	5367	5367	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Synthesis and characterization of new radioligands for the mammalian melanin-concentrating_hormone -LRB- MCH -RRB- receptor .
11459838	0	melanin-concentrating_hormone	69,98	mch-r2	109,115	melanin-concentrating hormone	mch-r2	5367	84539	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Identification and pharmacological characterization of a novel human melanin-concentrating_hormone receptor , mch-r2 .
17897030	0	melanin-concentrating_hormone_1-receptor	15,55	MCH1-R	57,63	melanin-concentrating hormone 1-receptor	MCH1-R	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Aminoquinoline melanin-concentrating_hormone_1-receptor -LRB- MCH1-R -RRB- antagonists .
19457661	0	melanin-concentrating_hormone_1-receptor	50,90	MCH1R	92,97	melanin-concentrating hormone 1-receptor	MCH1R	83567(Tax:10116)	83567(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Identification of 2-aminobenzimidazoles as potent melanin-concentrating_hormone_1-receptor -LRB- MCH1R -RRB- antagonists .
17329101	0	melanin-concentrating_hormone_receptor-1	56,96	MCH-R1	98,104	melanin-concentrating hormone receptor-1	MCH-R1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Thienopyrimidinone_bis-aminopyrrolidine ureas as potent melanin-concentrating_hormone_receptor-1 -LRB- MCH-R1 -RRB- antagonists .
18682323	0	melanin-concentrating_hormone_receptor_1	64,104	MCH-R1	106,112	melanin-concentrating hormone receptor 1	MCH-R1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of 1,3-disubstituted-1H-pyrrole derivatives as potent melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
19500982	0	melanin-concentrating_hormone_receptor_1	47,87	MCH-R1	89,95	melanin-concentrating hormone receptor 1	MCH-R1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Optimization of piperidin-4-yl-urea-containing melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists : Reducing hERG-associated liabilities .
21420863	0	melanin-concentrating_hormone_receptor_1	77,117	MCH-R1	119,125	melanin-concentrating hormone receptor 1	MCH-R1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and SAR investigations of novel 2-arylbenzimidazole derivatives as melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
22249825	0	melanin-concentrating_hormone_receptor_1	23,63	MCH-R1	65,71	melanin-concentrating hormone receptor 1	MCH-R1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Antiobesity effects of melanin-concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
18760349	0	melanin-concentrating_hormone_receptor_1	14,54	RGS8	68,72	melanin-concentrating hormone receptor 1	RGS8	2847	85397	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of melanin-concentrating_hormone_receptor_1 signaling by RGS8 with the receptor third intracellular loop .
20144885	0	melanin_concentrating_hormone	65,94	MCH	96,99	melanin concentrating hormone	MCH	5367	5367	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Distribution of hypothalamic neurons with orexin -LRB- hypocretin -RRB- or melanin_concentrating_hormone -LRB- MCH -RRB- immunoreactivity and multisynaptic connections with diaphragm motoneurons .
23411080	0	melanin_concentrating_hormone_receptor_1	74,114	MCH-R1	116,122	melanin concentrating hormone receptor 1	MCH-R1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Synthesis and SAR study of pyrrolo -LSB- 3,4-b -RSB- pyridin-7 -LRB- 6H -RRB- - one derivatives as melanin_concentrating_hormone_receptor_1 -LRB- MCH-R1 -RRB- antagonists .
20724156	0	melanin_concentrating_hormone_receptor_1	55,95	MCHR1	97,102	melanin concentrating hormone receptor 1	MCHR1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of novel , orally available benzimidazoles as melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonists .
22487182	0	melanin_concentrating_hormone_receptor_1	54,94	MCHR1	96,101	melanin concentrating hormone receptor 1	MCHR1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Design and optimization of quinazoline derivatives as melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonists .
22497763	0	melanin_concentrating_hormone_receptor_1	54,94	MCHR1	96,101	melanin concentrating hormone receptor 1	MCHR1	2847	2847	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Design and optimization of quinazoline derivatives as melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonists : part 2 .
22542010	0	melanin_concentrating_hormone_receptor_1	21,61	MCHR1	63,68	melanin concentrating hormone receptor 1	MCHR1	207911(Tax:10090)	207911(Tax:10090)	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of a novel melanin_concentrating_hormone_receptor_1 -LRB- MCHR1 -RRB- antagonist with reduced hERG inhibition .
12503610	0	melanocortin-1_receptor	25,48	MC1R	50,54	melanocortin-1 receptor	MC1R	17199(Tax:10090)	17199(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Homologous regulation of melanocortin-1_receptor -LRB- MC1R -RRB- expression in melanoma_tumor cells in vivo .
23915680	0	melanocortin-1_receptor	125,148	MC1R	155,159	melanocortin-1 receptor	MC1R	106145744	106145744	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Color differences among feral pigeons -LRB- Columba_livia -RRB- are not attributable to sequence variation in the coding region of the melanocortin-1_receptor gene -LRB- MC1R -RRB- .
17456795	0	melanocortin-2_receptor	67,90	MC2R	92,96	melanocortin-2 receptor	MC2R	4158	4158	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Differential regulation of the human adrenocorticotropin_receptor -LSB- melanocortin-2_receptor -LRB- MC2R -RRB- -RSB- by human MC2R_accessory_protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells .
20882712	0	melanocortin-3_receptor	17,40	MC3R	42,46	melanocortin-3 receptor	MC3R	4159	4159	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the melanocortin-3_receptor -LRB- MC3R -RRB- gene : Impact on human obesity or adiposity .
11257308	0	melanocortin-4_receptor	88,111	Agouti-related_protein	0,22	melanocortin-4 receptor	Agouti-related protein	17202(Tax:10090)	11604(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Agouti-related_protein functions as an inverse agonist at a constitutively active brain melanocortin-4_receptor .
14709157	0	melanocortin-4_receptor	73,96	Agouti-related_protein	0,22	melanocortin-4 receptor	Agouti-related protein	4160	181	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Agouti-related_protein -LRB- 83-132 -RRB- is a competitive antagonist at the human melanocortin-4_receptor : no evidence for differential interactions with pro-opiomelanocortin-derived ligands .
15996791	0	melanocortin-4_receptor	36,59	Agouti-related_protein	0,22	melanocortin-4 receptor	Agouti-related protein	17202(Tax:10090)	11604(Tax:10090)	Gene	Gene	antagonist|amod|START_ENTITY END_ENTITY|dep|antagonist	Agouti-related_protein : more than a melanocortin-4_receptor antagonist ?
10656927	0	melanocortin-4_receptor	34,57	MC4R	59,63	melanocortin-4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A missense variant of the porcine melanocortin-4_receptor -LRB- MC4R -RRB- gene is associated with fatness , growth , and feed intake traits .
15533382	0	melanocortin-4_receptor	27,50	MC4R	52,56	melanocortin-4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of the melanocortin-4_receptor -LRB- MC4R -RRB- gene in children with premature_pubarche and adolescent girls with hyperandrogenism .
16441297	0	melanocortin-4_receptor	48,71	MC4R	73,77	melanocortin-4 receptor	MC4R	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An effect of a missense mutation in the porcine melanocortin-4_receptor -LRB- MC4R -RRB- gene on production traits in Polish pig breeds is doubtful .
17286227	0	melanocortin-4_receptor	39,62	MC4R	69,73	melanocortin-4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|appos|END_ENTITY	A novel non-synonymous mutation in the melanocortin-4_receptor gene -LRB- MC4R -RRB- in a 2-year-old Austrian girl with extreme obesity .
17306938	0	melanocortin-4_receptor	51,74	MC4R	45,49	melanocortin-4 receptor	MC4R	483961(Tax:9615)	483961(Tax:9615)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Polymorphism and chromosomal location of the MC4R -LRB- melanocortin-4_receptor -RRB- gene in the dog and red fox .
17312994	0	melanocortin-4_receptor	47,70	MC4R	72,76	melanocortin-4 receptor	MC4R	428485(Tax:9031)	428485(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The single nucleotide polymorphisms of chicken melanocortin-4_receptor -LRB- MC4R -RRB- gene and their association analysis with carcass traits .
20374902	0	melanocortin-4_receptor	19,42	MC4R	44,48	melanocortin-4 receptor	MC4R	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of the melanocortin-4_receptor -LRB- MC4R -RRB- with feed intake , growth , fatness and carcass composition in pigs raised in Poland .
22062063	0	melanocortin-4_receptor	69,92	MC4R	94,98	melanocortin-4 receptor	MC4R	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Allelic incidence in several pig breeds of a missense variant of pig melanocortin-4_receptor -LRB- MC4R -RRB- gene associated with carcass and productive traits ; its relation to IGF2 genotype .
22444853	0	melanocortin-4_receptor	47,70	MC4R	73,77	melanocortin-4 receptor	MC4R	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Asp298Asn missense mutation in the porcine melanocortin-4_receptor -LRB- MC4R -RRB- gene can be used to affect growth and carcass traits without an effect on meat quality .
10652218	0	melanocortin-4_receptor	104,127	agouti-related_protein	81,103	melanocortin-4 receptor	agouti-related protein	25635(Tax:10116)	25582(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Differential regulation of melanin-concentrating hormone and orexin genes in the agouti-related_protein / melanocortin-4_receptor system .
11352754	0	melanocortin-4_receptor	34,57	agouti-related_protein	101,123	melanocortin-4 receptor	agouti-related protein	17202(Tax:10090)	11604(Tax:10090)	Gene	Gene	studies|nmod|START_ENTITY studies|dep|identification identification|nmod|END_ENTITY	Structure activity studies of the melanocortin-4_receptor by in vitro mutagenesis : identification of agouti-related_protein -LRB- AGRP -RRB- , melanocortin agonist and synthetic peptide antagonist interaction determinants .
11487744	0	melanocortin-4_receptor	23,46	agouti-related_protein	48,70	melanocortin-4 receptor	agouti-related protein	4160	181	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Mutational analysis of melanocortin-4_receptor , agouti-related_protein , and alpha-melanocyte-stimulating_hormone genes in severely obese children .
15084118	0	melanocortin-4_receptor	58,81	agouti-related_protein	27,49	melanocortin-4 receptor	agouti-related protein	17202(Tax:10090)	11604(Tax:10090)	Gene	Gene	interactions|amod|START_ENTITY Identification|dep|interactions Identification|nmod|END_ENTITY	Identification of putative agouti-related_protein -LRB- 87-132 -RRB- - melanocortin-4_receptor interactions by homology molecular modeling and validation using chimeric peptide ligands .
15615519	0	melanocortin-4_receptor	112,135	agouti-related_protein	41,63	melanocortin-4 receptor	agouti-related protein	4160	181	Gene	Gene	antagonist|amod|START_ENTITY conversion|nmod|antagonist studies|dep|conversion studies|nmod|END_ENTITY	Stereochemical studies of the monocyclic agouti-related_protein -LRB- 103-122 -RRB- Arg-Phe-Phe residues : conversion of a melanocortin-4_receptor antagonist into an agonist and results in the discovery of a potent and selective melanocortin-1 agonist .
18974267	0	melanocortin-4_receptor	122,145	beta-melanocyte-stimulating_hormone	86,121	melanocortin-4 receptor	beta-melanocyte-stimulating hormone	4160	5443	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating_hormone / melanocortin-4_receptor signaling .
7956366	0	melanocortin-5_receptor	26,49	MC5R	56,60	melanocortin-5 receptor	MC5R	4161	4161	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human melanocortin-5_receptor gene -LRB- MC5R -RRB- to chromosome band 18p11 .2 by fluorescence in situ hybridization .
11030758	0	melanocortin_1_receptor	27,50	MC1R	52,56	melanocortin 1 receptor	MC1R	4157	4157	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pleiotropic effects of the melanocortin_1_receptor -LRB- MC1R -RRB- gene on human pigmentation .
14961558	0	melanocortin_1_receptor	29,52	MC1R	54,58	melanocortin 1 receptor	MC1R	4157	4157	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of four novel melanocortin_1_receptor -LRB- MC1R -RRB- gene variants in a Mediterranean population .
15963603	0	melanocortin_1_receptor	21,44	MC1R	46,50	melanocortin 1 receptor	MC1R	4157	4157	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	The relation between melanocortin_1_receptor -LRB- MC1R -RRB- variation and the generation of phenotypic diversity in the cutaneous response to ultraviolet radiation .
16978179	0	melanocortin_1_receptor	17,40	MC1R	42,46	melanocortin 1 receptor	MC1R	100340038(Tax:9986)	100340038(Tax:9986)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the melanocortin_1_receptor -LRB- MC1R -RRB- gene are associated with coat colours in the domestic_rabbit -LRB- Oryctolagus_cuniculus -RRB- .
18717860	0	melanocortin_1_receptor	29,52	MC1R	54,58	melanocortin 1 receptor	MC1R	4157	4157	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Main pigmentary features and melanocortin_1_receptor -LRB- MC1R -RRB- gene polymorphisms in the population of the Canary Islands .
19706191	0	melanocortin_1_receptor	35,58	MC1R	60,64	melanocortin 1 receptor	MC1R	106503093	106503093	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Missense and nonsense mutations in melanocortin_1_receptor -LRB- MC1R -RRB- gene of different goat breeds : association with red and black coat colour phenotypes but with unexpected evidences .
20594318	0	melanocortin_1_receptor	44,67	MC1R	69,73	melanocortin 1 receptor	MC1R	100340038(Tax:9986)	100340038(Tax:9986)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A composite six bp in-frame deletion in the melanocortin_1_receptor -LRB- MC1R -RRB- gene is associated with the Japanese brindling coat colour in rabbits -LRB- Oryctolagus_cuniculus -RRB- .
20634512	0	melanocortin_1_receptor	19,42	MC1R	44,48	melanocortin 1 receptor	MC1R	100542545	100542545	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variability of the melanocortin_1_receptor -LRB- MC1R -RRB- gene explains the segregation of the bronze locus in turkey -LRB- Meleagris_gallopavo -RRB- .
21214968	0	melanocortin_1_receptor	2,25	MC1R	27,31	melanocortin 1 receptor	MC1R	102099064	102099064	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	A melanocortin_1_receptor -LRB- MC1R -RRB- gene polymorphism is useful for authentication of Massese sheep dairy products .
22011200	0	melanocortin_1_receptor	70,93	MC1R	95,99	melanocortin 1 receptor	MC1R	4157	4157	Gene	Gene	ligand|amod|START_ENTITY ligand|appos|END_ENTITY	Development of melanoma-targeted polymer micelles by conjugation of a melanocortin_1_receptor -LRB- MC1R -RRB- specific ligand .
24830563	0	melanocortin_1_receptor	40,63	MC1R	65,69	melanocortin 1 receptor	MC1R	427562(Tax:9031)	427562(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of exonic variants within the melanocortin_1_receptor -LRB- MC1R -RRB- gene in Black Silky , White Leghorn and Golden duckwing Araucana chicken .
23724142	0	melanocortin_2_receptor	56,79	MC2R	81,85	melanocortin 2 receptor	MC2R	4158	4158	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization and functional regulation of melanocortin_2_receptor -LRB- MC2R -RRB- in the sea bass .
26576642	0	melanocortin_2_receptor_accessory_protein	20,61	MRAP	63,67	melanocortin 2 receptor accessory protein	MRAP	56246	56246	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	H295R expression of melanocortin_2_receptor_accessory_protein -LRB- MRAP -RRB- results in ACTH responsiveness .
21139347	0	melanocortin_2_receptor_accessory_protein_2	32,75	MRAP2	77,82	melanocortin 2 receptor accessory protein 2	MRAP2	112609	112609	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	siRNA-mediated knockdown of the melanocortin_2_receptor_accessory_protein_2 -LRB- MRAP2 -RRB- gene confers resistance to methylmercury on HEK293 cells .
11889220	0	melanocortin_3_receptor	8,31	MC3R	38,42	melanocortin 3 receptor	MC3R	4159	4159	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A novel melanocortin_3_receptor gene -LRB- MC3R -RRB- mutation associated with severe obesity .
21695122	0	melanocortin_3_receptor	20,43	MC3R	50,54	melanocortin 3 receptor	MC3R	4159	4159	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic variants of melanocortin_3_receptor gene -LRB- MC3R -RRB- and weight_loss in obesity : a randomised trial of hypo-energetic high - versus low-fat diets .
16420261	0	melanocortin_4_receptor	17,40	MC4R	42,46	melanocortin 4 receptor	MC4R	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association of a melanocortin_4_receptor -LRB- MC4R -RRB- polymorphism with performance traits in Lithuanian White pigs .
16879346	0	melanocortin_4_receptor	26,49	MC4R	51,55	melanocortin 4 receptor	MC4R	397359(Tax:9823)	397359(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of the porcine melanocortin_4_receptor -LRB- MC4R -RRB- gene as a positional candidate for a fatness_QTL in a cross between Landrace and Hampshire .
19301229	0	melanocortin_4_receptor	17,40	MC4R	42,46	melanocortin 4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the melanocortin_4_receptor -LRB- MC4R -RRB- gene in obese patients in Norway .
20820905	0	melanocortin_4_receptor	25,48	MC4R	50,54	melanocortin 4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic diversity of the melanocortin_4_receptor -LRB- MC4R -RRB- gene and its association with slaughter traits in the Landes goose .
23124548	0	melanocortin_4_receptor	25,48	MC4R	55,59	melanocortin 4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Selected variants of the melanocortin_4_receptor gene -LRB- MC4R -RRB- do not confer susceptibility to female pattern hair loss .
23947663	0	melanocortin_4_receptor	34,57	MC4R	59,63	melanocortin 4 receptor	MC4R	100355375(Tax:9986)	100355375(Tax:9986)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A missense mutation in the rabbit melanocortin_4_receptor -LRB- MC4R -RRB- gene is associated with finishing weight in a meat rabbit line .
25103139	0	melanocortin_4_receptor	41,64	MC4R	71,75	melanocortin 4 receptor	MC4R	4160	4160	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variation in and near the melanocortin_4_receptor gene -LRB- MC4R -RRB- is associated with body mass index in American Indian adults and children .
23996627	0	melanocortin_receptor	10,31	MCR	33,36	melanocortin receptor	MCR	4306	4306	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Family of melanocortin_receptor -LRB- MCR -RRB- genes in mammals-mutations , polymorphisms and phenotypic effects .
10687856	0	melanocortin_receptor-5	29,52	MC5-R	54,59	melanocortin receptor-5	MC5-R	507987(Tax:9913)	507987(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of melanocortin_receptor-5 -LRB- MC5-R -RRB- in the bovine adrenal cortex .
12018414	0	melanocortin_receptor_1	51,74	MC1R	76,80	melanocortin receptor 1	MC1R	281298(Tax:9913)	281298(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Holstein 's milk detection in cheeses inferred from melanocortin_receptor_1 -LRB- MC1R -RRB- gene polymorphism .
14669512	0	melanocortin_receptor_1	32,55	MC1R	56,60	melanocortin receptor 1	MC1R	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Studies of the relationship of melanocortin_receptor_1 -LRB- MC1R -RRB- gene with coat color phenotype in pigs -RSB- .
15524286	0	melanocortin_receptor_1	43,66	MC1R	68,72	melanocortin receptor 1	MC1R	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Single nucleotide polymorphism analysis on melanocortin_receptor_1 -LRB- MC1R -RRB- of Chinese native pig .
17369176	0	melanocortin_receptor_1	26,49	MC1R	51,55	melanocortin receptor 1	MC1R	281298(Tax:9913)	281298(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Relationship between the melanocortin_receptor_1 -LRB- MC1R -RRB- gene and the coat color phenotype in cattle -RSB- .
17884687	0	melanocortin_receptor_1	14,37	MC1R	39,43	melanocortin receptor 1	MC1R	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variations of melanocortin_receptor_1 -LRB- MC1R -RRB- gene in three pig breeds .
26431999	0	melanocortin_receptor_1	73,96	MC1R	98,102	melanocortin receptor 1	MC1R	494018(Tax:9823)	494018(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of genetic diversity and selection at the coding region of the melanocortin_receptor_1 -LRB- MC1R -RRB- gene in Tibetan pigs and Landrace pigs .
20962024	0	melanocortin_receptor_2	26,49	MC2R	51,55	melanocortin receptor 2	MC2R	4158	4158	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Loss of the C terminus of melanocortin_receptor_2 -LRB- MC2R -RRB- results in impaired cell surface expression and ACTH insensitivity .
24315371	0	melanocortin_receptor_4	35,58	Sim1	62,66	melanocortin receptor 4	Sim1	17202(Tax:10090)	20464(Tax:10090)	Gene	Gene	START_ENTITY|nmod|neurons neurons|amod|END_ENTITY	Glutamate mediates the function of melanocortin_receptor_4 on Sim1 neurons in body weight regulation .
18359160	0	melanocortin_receptor_type_2	36,64	MC2R	66,70	melanocortin receptor type 2	MC2R	4158	4158	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of polymorphisms in the melanocortin_receptor_type_2 -LRB- MC2R , ACTH_receptor -RRB- gene with heroin_addiction .
37848	0	melanocyte-stimulating_hormone-release_inhibiting_factor	23,79	MIF	18,21	melanocyte-stimulating hormone-release inhibiting factor	MIF	4282	4282	Gene	Gene	influence|appos|START_ENTITY influence|nmod|END_ENTITY	-LSB- The influence of MIF -LRB- melanocyte-stimulating_hormone-release_inhibiting_factor -RRB- on psychomotor function and mood in parkinsonian patients .
4614981	0	melanocyte-stimulating_hormone-release_inhibiting_factor	10,66	MIF	68,71	melanocyte-stimulating hormone-release inhibiting factor	MIF	4282	4282	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of melanocyte-stimulating_hormone-release_inhibiting_factor -LRB- MIF -RRB- in Parkinson 's _ syndrom .
3607524	0	melanocyte_stimulating_hormone	17,47	MSH	49,52	melanocyte stimulating hormone	MSH	5443	5443	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Concentration of melanocyte_stimulating_hormone -LRB- MSH -RRB- within specific brain regions in aged squirrel monkeys .
10706124	0	melanoma_antigen	17,33	MAGE	35,39	melanoma antigen	MAGE	17276(Tax:10090)	17276(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mage-b4 , a novel melanoma_antigen -LRB- MAGE -RRB- gene specifically expressed during germ cell differentiation .
9323494	0	melanoma_antigen-1	17,35	MAGE-1	37,43	melanoma antigen-1	MAGE-1	4100	4100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Heterogeneity of melanoma_antigen-1 -LRB- MAGE-1 -RRB- gene and protein expression in malignant_melanoma .
21042944	0	melanoma_antigen-encoding_gene-1	25,57	MAGE-1	59,65	melanoma antigen-encoding gene-1	MAGE-1	4100	4100	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical significance of melanoma_antigen-encoding_gene-1 -LRB- MAGE-1 -RRB- expression and its correlation with poor prognosis in differentiated advanced_gastric_cancer .
17982057	0	melanoma_cell_adhesion_molecule	13,44	CD146	52,57	melanoma cell adhesion molecule	CD146	4162	4162	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	Dual role of melanoma_cell_adhesion_molecule -LRB- MCAM -RRB- / CD146 in lymphocyte endothelium interaction : MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor .
17569608	0	melanoma_cell_adhesion_molecule	30,61	MCAM	63,67	melanoma cell adhesion molecule	MCAM	4162	4162	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Stratification of patients by melanoma_cell_adhesion_molecule -LRB- MCAM -RRB- expression on the basis of risk : implications for sentinel_lymph_node_biopsy .
22459580	0	melanoma_differentiation-associated_gene_5	28,70	MDA5	72,76	melanoma differentiation-associated gene 5	MDA5	424185(Tax:9031)	424185(Tax:9031)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of chicken melanoma_differentiation-associated_gene_5 -LRB- MDA5 -RRB- from alternative translation initiation .
26504669	0	melanoma_differentiation-associated_protein_5	23,68	MDA5	70,74	melanoma differentiation-associated protein 5	MDA5	71586(Tax:10090)	71586(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Targeted activation of melanoma_differentiation-associated_protein_5 -LRB- MDA5 -RRB- for immunotherapy of pancreatic_carcinoma .
24046408	0	melanoma_differentiation_associated_gene_5	58,100	MDA5	102,106	melanoma differentiation associated gene 5	MDA5	64135	64135	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Identification and expression profiling analysis of goose melanoma_differentiation_associated_gene_5 -LRB- MDA5 -RRB- gene .
11027436	0	melanoma_inhibitory_activity	18,46	MIA	48,51	melanoma inhibitory activity	MIA	8190	8190	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of melanoma_inhibitory_activity -LRB- MIA -RRB- enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo .
11157741	0	melanoma_inhibitory_activity	24,52	MIA	54,57	melanoma inhibitory activity	MIA	8190	8190	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The extracellular human melanoma_inhibitory_activity -LRB- MIA -RRB- protein adopts an SH3 domain-like fold .
15958794	0	melanophilin	37,49	MLPH	56,60	melanophilin	MLPH	171531(Tax:10090)	171531(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal assignment of the canine melanophilin gene -LRB- MLPH -RRB- : a candidate gene for coat color dilution in Pinschers .
17519392	0	melanophilin	12,24	MLPH	31,35	melanophilin	MLPH	607077(Tax:9615)	607077(Tax:9615)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A noncoding melanophilin gene -LRB- MLPH -RRB- SNP at the splice donor of exon 1 represents a candidate causal mutation for coat color dilution in dogs .
15760894	0	melanophilin	36,48	myosin_Va	80,89	melanophilin	myosin Va	79083	4644	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	Activation of myosin_Va function by melanophilin , a specific docking partner of myosin_Va .
17513864	0	melanophilin	98,110	myosin_Va	28,37	melanophilin	myosin Va	79083	4644	Gene	Gene	domain|nmod|START_ENTITY site|nmod|domain site|compound|END_ENTITY	Identification of a minimal myosin_Va binding site within an intrinsically unstructured domain of melanophilin .
12230555	0	melanotransferrin	62,79	transferrin	39,50	melanotransferrin	transferrin	4241	7018	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	The soluble form of the membrane-bound transferrin homologue , melanotransferrin , inefficiently donates iron to cells via nonspecific internalization and degradation of the protein .
12688510	0	melanotransferrin	82,99	transferrin	59,70	melanotransferrin	transferrin	4241	7018	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Iron uptake by melanoma cells from the soluble form of the transferrin homologue , melanotransferrin .
15716025	0	melanotransferrin	62,79	transferrin	39,50	melanotransferrin	transferrin	4241	22041(Tax:10090)	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	Examination of the distribution of the transferrin homologue , melanotransferrin -LRB- tumour antigen p97 -RRB- , in mouse and human .
15577322	0	melastatin_1	6,18	MITF	43,47	melastatin 1	MITF	4308	4286	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Human melastatin_1 -LRB- TRPM1 -RRB- is regulated by MITF and produces multiple polypeptide isoforms in melanocytes and melanoma .
20726823	0	melatonin_receptor	44,62	MTNR1A	64,70	melatonin receptor	MTNR1A	4543	4543	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Analysis of genetic variations in the human melatonin_receptor -LRB- MTNR1A , MTNR1B -RRB- genes and antipsychotics-induced tardive_dyskinesia in schizophrenia .
21211471	0	melatonin_receptor_1A	22,43	MTNR1A	45,51	melatonin receptor 1A	MTNR1A	443022(Tax:9940)	443022(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism at the melatonin_receptor_1A -LRB- MTNR1A -RRB- gene in Sarda ewes affects fertility after AI in the spring .
21497385	0	melatonin_receptor_1A	56,77	MTNR1A	79,85	melatonin receptor 1A	MTNR1A	539948(Tax:9913)	539948(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the Mediterranean Italian buffaloes melatonin_receptor_1A -LRB- MTNR1A -RRB- gene and its association with reproductive seasonality .
21652546	0	melatonin_receptor_1A	4,25	MTNR1A	27,33	melatonin receptor 1A	MTNR1A	4543	4543	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The melatonin_receptor_1A -LRB- MTNR1A -RRB- gene is associated with recurrent and idiopathic calcium nephrolithiasis .
22935159	0	melatonin_receptor_1A	20,41	MTNR1A	43,49	melatonin receptor 1A	MTNR1A	4543	4543	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between melatonin_receptor_1A -LRB- MTNR1A -RRB- gene polymorphism and the reproductive performance of Mediterranean Italian buffaloes .
24595444	0	melatonin_receptor_1A	20,41	MTNR1A	43,49	melatonin receptor 1A	MTNR1A	4543	4543	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between melatonin_receptor_1A -LRB- MTNR1A -RRB- gene single-nucleotide polymorphisms and the velvet antler yield of Sika deer .
27038909	0	melatonin_receptor_1A	23,44	MTNR1A	46,52	melatonin receptor 1A	MTNR1A	4543	4543	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	DNA methylation within melatonin_receptor_1A -LRB- MTNR1A -RRB- mediates paternally transmitted genetic variant effect on asthma_plus_rhinitis .
17108395	0	melatonin_receptor_1B	12,33	MTNR1B	40,46	melatonin receptor 1B	MTNR1B	4544	4544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of melatonin_receptor_1B gene -LRB- MTNR1B -RRB- in adolescent idiopathic scoliosis -- a genetic association study .
19455304	0	melatonin_receptor_1B	32,53	MTNR1B	60,66	melatonin receptor 1B	MTNR1B	4544	4544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variation in the melatonin_receptor_1B gene -LRB- MTNR1B -RRB- is associated with decreased early-phase insulin response .
25898821	0	melatonin_receptor_1B	21,42	MTNR1B	49,55	melatonin receptor 1B	MTNR1B	4544	4544	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The polymorphisms of melatonin_receptor_1B gene -LRB- MTNR1B -RRB- -LRB- rs4753426 and rs10830963 -RRB- and susceptibility to adolescent_idiopathic_scoliosis : a meta-analysis .
6418521	0	melittin	55,63	phospholipase_A2	81,97	melittin	phospholipase A2	406130(Tax:7460)	104974671	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Stimulation of anterior pituitary prolactin release by melittin , an activator of phospholipase_A2 .
12456779	0	meltrin_alpha	26,39	ADAM12	18,24	meltrin alpha	ADAM12	8038	8038	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The expression of ADAM12 -LRB- meltrin_alpha -RRB- in human giant_cell_tumours of bone .
9622634	0	meltrin_alpha	51,64	ADAM19	84,90	meltrin alpha	ADAM19	11489(Tax:10090)	11492(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Spatially - and temporally-restricted expression of meltrin_alpha -LRB- ADAM12 -RRB- and beta -LRB- ADAM19 -RRB- in mouse embryo .
9417060	0	meltrin_alpha	41,54	ADAM_12	32,39	meltrin alpha	ADAM 12	8038	8038	Gene	Gene	form|appos|START_ENTITY form|nmod|END_ENTITY	A novel , secreted form of human ADAM_12 -LRB- meltrin_alpha -RRB- provokes myogenesis in vivo .
23300075	0	membrane-associated_RING-CH-8	22,51	MARCH-8	53,60	membrane-associated RING-CH-8	MARCH-8	220972	220972	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Ubiquitination by the membrane-associated_RING-CH-8 -LRB- MARCH-8 -RRB- ligase controls steady-state cell surface expression of tumor_necrosis_factor-related_apoptosis_inducing_ligand _ -LRB- TRAIL -RRB- _ receptor_1 .
8701988	0	membrane-associated_protein	55,82	MAP17	84,89	membrane-associated protein	MAP17	10158	10158	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Identification and partial characterization of a novel membrane-associated_protein -LRB- MAP17 -RRB- up-regulated in human carcinomas and modulating cell replication and tumor growth .
11735324	0	membrane-bound	41,55	COMT	98,102	membrane-bound	COMT	19	1312	Gene	Gene	catechol-o-methyltransferase|amod|START_ENTITY catechol-o-methyltransferase|appos|END_ENTITY	Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase -LRB- COMT -RRB- estimated by enzyme kinetic values .
23351565	0	membrane-bound	18,32	COMT	33,37	membrane-bound	COMT	19	1312	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability .
19131520	0	membrane-bound	15,29	heme_oxygenase-1	36,52	membrane-bound	heme oxygenase-1	19	3162	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Measurement of membrane-bound human heme_oxygenase-1 activity using a chemically defined assay system .
1720417	0	membrane-bound	66,80	interleukin-2	93,106	membrane-bound	interleukin-2	19	3558	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	The immunosuppressive agent FK506 inhibits in vitro expression of membrane-bound and soluble interleukin-2 receptors on resting but not on activated human lymphocytes .
11231300	0	membrane-bound_transferrin-like_protein	45,84	MTf	86,89	membrane-bound transferrin-like protein	MTf	30060(Tax:10090)	30060(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and promoter analysis of the mouse membrane-bound_transferrin-like_protein -LRB- MTf -RRB- gene .
9648071	0	membrane-type-1-matrix_metalloproteinase	18,58	MMP-2	131,136	membrane-type-1-matrix metalloproteinase	MMP-2	17387(Tax:10090)	17390(Tax:10090)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of murine membrane-type-1-matrix_metalloproteinase -LRB- MT-1-MMP -RRB- and its metanephric developmental regulation with respect to MMP-2 and its inhibitor .
16752205	0	membrane-type-1_matrix_metalloproteinase	44,84	Cyclooxygenase-2	0,16	membrane-type-1 matrix metalloproteinase	Cyclooxygenase-2	4323	5743	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|expression expression|amod|END_ENTITY	Cyclooxygenase-2 expression correlates with membrane-type-1_matrix_metalloproteinase expression in colorectal_cancer tissue .
25774665	0	membrane-type-1_matrix_metalloproteinase	2,42	discoidin_domain_receptor_1	53,80	membrane-type-1 matrix metalloproteinase	discoidin domain receptor 1	4323	780	Gene	Gene	START_ENTITY|dep|axis axis|amod|END_ENTITY	A membrane-type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- - discoidin_domain_receptor_1 axis regulates collagen-induced apoptosis in breast_cancer cells .
19123976	0	membrane-type_1_matrix_metalloproteinase	20,60	Caveolin-1	0,10	membrane-type 1 matrix metalloproteinase	Caveolin-1	4323	857	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Caveolin-1 inhibits membrane-type_1_matrix_metalloproteinase activity .
10822133	0	membrane-type_1_matrix_metalloproteinase	14,54	MT1-MMP	56,63	membrane-type 1 matrix metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of membrane-type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- on prostate_cancer cell lines .
11757910	0	membrane-type_1_matrix_metalloproteinase	14,54	MT1-MMP	56,63	membrane-type 1 matrix metalloproteinase	MT1-MMP	100861171	100861171	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of membrane-type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- mRNA in trophoblast and endometrial epithelial cell populations of the synepitheliochorial placenta of goats -LRB- Capra_hircus -RRB- .
11235994	0	membrane-type_1_matrix_metalloproteinase	66,106	progelatinase_A	38,53	membrane-type 1 matrix metalloproteinase	progelatinase A	4323	4313	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Enhanced production and activation of progelatinase_A mediated by membrane-type_1_matrix_metalloproteinase in human oral_squamous_cell_carcinomas : implications for lymph_node_metastasis .
9212749	0	membrane-type_1_matrix_metalloproteinase	14,54	progelatinase_A	73,88	membrane-type 1 matrix metalloproteinase	progelatinase A	4323	4313	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of membrane-type_1_matrix_metalloproteinase and activation of progelatinase_A in human osteoarthritic cartilage .
9609663	0	membrane-type_2_matrix_metalloproteinase	26,66	MMP15	73,78	membrane-type 2 matrix metalloproteinase	MMP15	4324	4324	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human membrane-type_2_matrix_metalloproteinase gene -LRB- MMP15 -RRB- to 16q12 .1 near DNA elements that are part of centromeric and non-centromeric heterochromatin of 11 human chromosomes .
25279184	0	membrane-type_2_matrix_metalloproteinase	18,58	hypoxia-inducible_factor-1a	70,97	membrane-type 2 matrix metalloproteinase	hypoxia-inducible factor-1a	4324	3091	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Overexpression of membrane-type_2_matrix_metalloproteinase induced by hypoxia-inducible_factor-1a in pancreatic_cancer : Implications for tumor progression and prognosis .
9796998	0	membrane-type_3_matrix_metalloproteinase	18,58	MT3-MMP	60,67	membrane-type 3 matrix metalloproteinase	MT3-MMP	4325	4325	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the membrane-type_3_matrix_metalloproteinase -LRB- MT3-MMP -RRB- in human brain tissues .
16352475	0	membrane-type_frizzled-related_protein	23,61	MFRP	63,67	membrane-type frizzled-related protein	MFRP	83552	83552	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation screen of the membrane-type_frizzled-related_protein -LRB- MFRP -RRB- gene in patients with inherited_retinal_degenerations .
7559440	0	membrane-type_matrix_metalloproteinase	29,67	MT-MMP-2	69,77	membrane-type matrix metalloproteinase	MT-MMP-2	4324	4324	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the second membrane-type_matrix_metalloproteinase -LRB- MT-MMP-2 -RRB- gene from a human placenta cDNA library .
9446829	0	membrane-type_matrix_metalloproteinase-1	14,54	MT-MMP-1	56,64	membrane-type matrix metalloproteinase-1	MT-MMP-1	4323	4323	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of membrane-type_matrix_metalloproteinase-1 -LRB- MT-MMP-1 -RRB- in early human placenta .
15381707	0	membrane-type_matrix_metalloproteinase-1	24,64	hemopexin	4,13	membrane-type matrix metalloproteinase-1	hemopexin	4323	3263	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The hemopexin domain of membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- Is not required for its activation of proMMP2 on cell surface but is essential for MT1-MMP-mediated invasion in three-dimensional type I collagen .
9179500	0	membrane-type_matrix_metalloproteinase-2	20,60	MT2-MMP	62,69	membrane-type matrix metalloproteinase-2	MT2-MMP	4324	4324	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Assignment of human membrane-type_matrix_metalloproteinase-2 -LRB- MT2-MMP -RRB- gene to 16q12 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis .
9062392	0	membrane-type_matrix_metalloproteinase_1	13,53	MT1-MMP	55,62	membrane-type matrix metalloproteinase 1	MT1-MMP	4323	4323	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of membrane-type_matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- expression in human fibroblasts by breast_adenocarcinoma cells .
18667779	0	membrane_Type_1-matrix_metalloproteinase	61,101	bone_morphogenetic_protein-2	11,39	membrane Type 1-matrix metalloproteinase	bone morphogenetic protein-2	4323	650	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of bone_morphogenetic_protein-2 on the expression of membrane_Type_1-matrix_metalloproteinase in human A549 lung_carcinoma cells -RSB- .
12885418	0	membrane_bound	4,18	adenosine_diphosphate_ribosylation_factor-1	46,89	membrane bound	adenosine diphosphate ribosylation factor-1	19	375	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The membrane_bound N-terminal domain of human adenosine_diphosphate_ribosylation_factor-1 -LRB- ARF1 -RRB- .
1940444	0	membrane_co-factor_protein	35,61	MCP	63,66	membrane co-factor protein	MCP	4179	4179	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and characterization of membrane_co-factor_protein -LRB- MCP -RRB- in human skin .
12055245	0	membrane_cofactor_protein	8,33	C4b	58,61	membrane cofactor protein	C4b	4179	721	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of membrane_cofactor_protein -LRB- CD46 -RRB- in regulation of C4b and C3b deposited on cells .
10361248	0	membrane_cofactor_protein	33,58	CD46	60,64	membrane cofactor protein	CD46	4179	4179	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated serum levels of soluble membrane_cofactor_protein -LRB- CD46 , MCP -RRB- in patients with systemic_lupus_erythematosus -LRB- SLE -RRB- .
10779410	0	membrane_cofactor_protein	22,47	CD46	16,20	membrane cofactor protein	CD46	4179	4179	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	Urine levels of CD46 -LRB- membrane_cofactor_protein -RRB- are increased in patients with glomerular_diseases .
7691939	0	membrane_cofactor_protein	47,72	CD46	74,78	membrane cofactor protein	CD46	4179	4179	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the promoter region of the membrane_cofactor_protein -LRB- CD46 -RRB- gene of the human complement system and comparison to a membrane_cofactor_protein-like genetic element .
10468303	0	membrane_cofactor_protein	14,39	MCP	41,44	membrane cofactor protein	MCP	4179	4179	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of membrane_cofactor_protein -LRB- MCP , CD46 -RRB- in human liver_diseases .
12112588	0	membrane_cofactor_protein	26,51	MCP	53,56	membrane cofactor protein	MCP	4179	4179	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of human membrane_cofactor_protein -LRB- MCP ; CD46 -RRB- on spermatozoa .
1694203	0	membrane_cofactor_protein	25,50	MCP	52,55	membrane cofactor protein	MCP	4179	4179	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Quantitative analysis of membrane_cofactor_protein -LRB- MCP -RRB- of complement .
2521358	0	membrane_cofactor_protein	26,51	MCP	53,56	membrane cofactor protein	MCP	4179	4179	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Structural gene for human membrane_cofactor_protein -LRB- MCP -RRB- of complement maps to within 100 kb of the 3 ' end of the C3b/C4b _ receptor gene .
7861396	0	membrane_cofactor_protein	46,71	MCP	73,76	membrane cofactor protein	MCP	4179	4179	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of the complement-regulatory protein membrane_cofactor_protein -LRB- MCP , CD46 -RRB- as a membrane-associated product in seminal plasma .
18781223	0	membrane_frizzled-related_protein	19,52	MFRP	54,58	membrane frizzled-related protein	MFRP	83552	83552	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of membrane_frizzled-related_protein -LRB- MFRP -RRB- gene with acute_angle-closure_glaucoma -- a pilot study .
8759753	0	membrane_inhibitor_of_reactive_lysis	69,105	CD59	107,111	membrane inhibitor of reactive lysis	CD59	966	966	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Analysis of the gene that encodes the complement regulatory protein , membrane_inhibitor_of_reactive_lysis -LRB- CD59 -RRB- .
1688497	0	membrane_inhibitor_of_reactive_lysis	12,48	phosphatidylinositol-specific_phospholipase_C	61,106	membrane inhibitor of reactive lysis	phosphatidylinositol-specific phospholipase C	966	23236	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Erythrocyte membrane_inhibitor_of_reactive_lysis : effects of phosphatidylinositol-specific_phospholipase_C on the isolated and cell-associated protein .
8445036	0	membrane_metalloendopeptidase	25,54	enkephalinase	56,69	membrane metalloendopeptidase	enkephalinase	4311	4311	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cellular localization of membrane_metalloendopeptidase -LRB- enkephalinase -RRB- in human endometrium during the ovarian cycle .
10389763	0	membrane_type-1_MMP	202,221	MMP-2	140,145	membrane type-1 MMP	MMP-2	4323	4313	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane_type-1_MMP .
10389763	0	membrane_type-1_MMP	202,221	MMP-2	42,47	membrane type-1 MMP	MMP-2	4323	4313	Gene	Gene	expression|nmod|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- by hepatocyte growth factor/scatter factor -LRB- HGF/SF -RRB- in human glioma cells : HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane_type-1_MMP .
14673954	0	membrane_type-1_matrix_metalloproteinase	53,93	Fibroblast_growth_factor-1	0,26	membrane type-1 matrix metalloproteinase	Fibroblast growth factor-1	4323	2246	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Fibroblast_growth_factor-1 transcriptionally induces membrane_type-1_matrix_metalloproteinase expression in prostate_carcinoma cell line .
16525713	0	membrane_type-1_matrix_metalloproteinase	14,54	MT1-MMP	56,63	membrane type-1 matrix metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of membrane_type-1_matrix_metalloproteinase , MT1-MMP in human breast_cancer and its impact on invasiveness of breast_cancer cells .
19855192	0	membrane_type-1_matrix_metalloproteinase	22,62	MT1-MMP	64,71	membrane type-1 matrix metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	A novel and selective membrane_type-1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- inhibitor reduces cancer cell motility and tumor growth .
16251193	0	membrane_type-1_matrix_metalloproteinase	55,95	pericentrin	12,23	membrane type-1 matrix metalloproteinase	pericentrin	4323	5116	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Centrosomal pericentrin is a direct cleavage target of membrane_type-1_matrix_metalloproteinase in humans but not in mice : potential implications for tumorigenesis .
10727639	0	membrane_type-5_matrix_metalloproteinase	28,68	MT5-MMP	70,77	membrane type-5 matrix metalloproteinase	MT5-MMP	83513(Tax:10116)	83513(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Developmental regulation of membrane_type-5_matrix_metalloproteinase -LRB- MT5-MMP -RRB- expression in the rat nervous system .
11949783	0	membrane_type_1-matrix_metalloproteinase	36,76	MT1-MMP	78,85	membrane type 1-matrix metalloproteinase	MT1-MMP	81707(Tax:10116)	81707(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of membrane_type_1-matrix_metalloproteinase -LRB- MT1-MMP -RRB- in osteoclasts in vivo .
9422789	0	membrane_type_1-matrix_metalloproteinase_1	109,151	Tissue_inhibitor_of_metalloproteinase-2	0,39	membrane type 1-matrix metalloproteinase 1	Tissue inhibitor of metalloproteinase-2	4323	7077	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- binds to the catalytic domain of the cell surface receptor , membrane_type_1-matrix_metalloproteinase_1 -LRB- MT1-MMP -RRB- .
16407177	0	membrane_type_1_matrix_metalloproteinase	67,107	MT1-MMP	126,133	membrane type 1 matrix metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	Type I collagen abrogates the clathrin-mediated internalization of membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- via the MT1-MMP hemopexin domain .
22002053	0	membrane_type_1_matrix_metalloproteinase	75,115	MT1-MMP	117,124	membrane type 1 matrix metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	translocation|amod|START_ENTITY translocation|compound|END_ENTITY	Fluid shear stress and sphingosine_1-phosphate activate calpain to promote membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- membrane translocation and endothelial invasion into three-dimensional collagen matrices .
24492617	0	membrane_type_1_matrix_metalloproteinase	45,85	Notch1	27,33	membrane type 1 matrix metalloproteinase	Notch1	4323	4851	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Noncanonical activation of Notch1 protein by membrane_type_1_matrix_metalloproteinase -LRB- MT1-MMP -RRB- controls melanoma cell proliferation .
17329256	0	membrane_type_1_matrix_metalloproteinase	85,125	reversion-inducing_cysteine-rich_protein_with_Kazal_motifs	4,62	membrane type 1 matrix metalloproteinase	reversion-inducing cysteine-rich protein with Kazal motifs	4323	8434	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The reversion-inducing_cysteine-rich_protein_with_Kazal_motifs -LRB- RECK -RRB- interacts with membrane_type_1_matrix_metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways .
18080692	0	membrane_type_I_matrix_metalloproteinase	16,56	MT1-MMP	58,65	membrane type I matrix metalloproteinase	MT1-MMP	4323	4323	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Correlation of membrane_type_I_matrix_metalloproteinase -LRB- MT1-MMP -RRB- expression with clinicomorphological features of tumor front in squamous_cell_carcinoma_of_the_larynx -RSB- .
18230350	0	membrane_type_matrix_metalloproteinase-1	34,74	MT1-MMP	76,83	membrane type matrix metalloproteinase-1	MT1-MMP	4323	4323	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Association between serum soluble membrane_type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- levels and bone_mineral_density , and biochemical markers in postmenopausal women .
9481784	0	membrane_type_matrix_metalloproteinase-1	31,71	MT1-MMP	73,80	membrane type matrix metalloproteinase-1	MT1-MMP	4323	4323	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of membrane_type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- in trophoblast cells of cultured mouse blastocysts and ectoplacental cones .
15781476	0	membrin	41,48	Arf-1	13,18	membrin	Arf-1	9570	375	Gene	Gene	Targeting|nmod|START_ENTITY Targeting|nmod|END_ENTITY	Targeting of Arf-1 to the early Golgi by membrin , an ER-Golgi SNARE .
1492386	0	menadione_reductase	13,32	cytochrome_B5	46,59	menadione reductase	cytochrome B5	24314(Tax:10116)	64001(Tax:10116)	Gene	Gene	Activity|nmod|START_ENTITY Activity|nmod|END_ENTITY	-LSB- Activity of menadione_reductase and level of cytochrome_B5 and P-450 in liver with varying supplies of vitamin_K and administration of pelentan to rats -RSB- .
25957482	0	meprin_b	51,59	nidogen-1	26,35	meprin b	nidogen-1	17288(Tax:10090)	18073(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Basement membrane protein nidogen-1 is a target of meprin_b in cisplatin nephrotoxicity .
10806353	0	meprin_beta	39,50	Mep1b	57,62	meprin beta	Mep1b	17288(Tax:10090)	17288(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the mouse metalloprotease meprin_beta gene -LRB- Mep1b -RRB- : alternative splicing in cancer cells .
12093806	0	meprin_beta	71,82	OS-9	32,36	meprin beta	OS-9	25727(Tax:10116)	362891(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	A selective interaction between OS-9 and the carboxyl-terminal tail of meprin_beta .
14577839	0	mer_A	44,49	mercuric_reductase	24,42	mer A	mercuric reductase	11372469	11372469	Gene	Gene	genes|appos|START_ENTITY genes|amod|END_ENTITY	Functional profiling of mercuric_reductase -LRB- mer_A -RRB- genes in biofilm communities of a technical scale biocatalyzer .
7608189	0	mercaptopyruvate_sulfurtransferase	10,44	rhodanese	88,97	mercaptopyruvate sulfurtransferase	rhodanese	192172(Tax:10116)	25274(Tax:10116)	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	Cytosolic mercaptopyruvate_sulfurtransferase is evolutionarily related to mitochondrial rhodanese .
7608189	1	mercaptopyruvate_sulfurtransferase	178,212	rhodanese	225,234	mercaptopyruvate sulfurtransferase	rhodanese	192172(Tax:10116)	25274(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Striking similarity in active site amino_acid sequence and the increase in the mercaptopyruvate_sulfurtransferase activity of rhodanese by site-directed mutagenesis .
9657305	0	mercurial-insensitive_water_channel	24,59	AQP-4	61,66	mercurial-insensitive water channel	AQP-4	25293(Tax:10116)	25293(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Selective expression of mercurial-insensitive_water_channel -LRB- AQP-4 -RRB- gene in Hensen and Claudius cells in the rat cochlea .
14577839	0	mercuric_reductase	24,42	mer_A	44,49	mercuric reductase	mer A	11372469	11372469	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Functional profiling of mercuric_reductase -LRB- mer_A -RRB- genes in biofilm communities of a technical scale biocatalyzer .
21167305	0	merlin	35,41	Moesin-ezrin-radixin-like_protein	0,33	merlin	Moesin-ezrin-radixin-like protein	4771	4771	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Moesin-ezrin-radixin-like_protein -LRB- merlin -RRB- mediates protein interacting with the carboxyl terminus-1 -LRB- PICT-1 -RRB- - induced growth inhibition of glioblastoma cells in the nucleus .
15743831	0	merlin	39,45	NF2	4,7	merlin	NF2	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	The NF2 tumor suppressor gene product , merlin , inhibits cell proliferation and cell cycle progression by repressing cyclin_D1 expression .
11703924	0	merlin	26,32	Nf2	4,7	merlin	Nf2	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	The Nf2 tumor suppressor , merlin , functions in Rac-dependent signaling .
19103750	0	merlin	33,39	neurofibromatosis_2	4,23	merlin	neurofibromatosis 2	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The neurofibromatosis_2 protein , merlin , regulates glial cell growth in an ErbB2 - and Src-dependent manner .
8666669	0	merlin	168,174	neurofibromatosis_2	130,149	merlin	neurofibromatosis 2	32979(Tax:7227)	4771	Gene	Gene	suppressor|appos|START_ENTITY suppressor|amod|END_ENTITY	Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis_2 tumor suppressor , merlin .
8830776	0	merosin	60,67	Merosin	0,7	merosin	Merosin	16773(Tax:10090)	16773(Tax:10090)	Gene	Gene	requirement|nmod|START_ENTITY END_ENTITY|dep|requirement	Merosin and laminin in myogenesis ; specific requirement for merosin in myotube stability and survival .
9169153	0	mesenchyme_fork_head-1	51,73	FKHL_14	42,49	mesenchyme fork head-1	FKHL 14	2303	2303	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Isolation of the mouse -LRB- MFH-1 -RRB- and human -LRB- FKHL_14 -RRB- mesenchyme_fork_head-1 genes reveals conservation of their gene and protein structures .
22216698	0	mesenchyme_forkhead_1	19,40	FOXC2	42,47	mesenchyme forkhead 1	FOXC2	2303	2303	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression of mesenchyme_forkhead_1 -LRB- FOXC2 -RRB- significantly correlates with the degree of lymph_node_metastasis in colorectal_cancer .
23614500	0	mesenchyme_forkhead_1	29,50	FoxC2	52,57	mesenchyme forkhead 1	FoxC2	2303	2303	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The clinical significance of mesenchyme_forkhead_1 -LRB- FoxC2 -RRB- in gastric_carcinoma .
17909009	0	mesothelin	35,45	MSLN	47,51	mesothelin	MSLN	10232	10232	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High cancer-specific expression of mesothelin -LRB- MSLN -RRB- is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif .
16231009	0	mesotrypsin	88,99	PAR-1	127,132	mesotrypsin	PAR-1	5646	2149	Gene	Gene	activate|nsubj|START_ENTITY activate|dobj|END_ENTITY	Activity of recombinant trypsin isoforms on human proteinase-activated receptors -LRB- PAR -RRB- : mesotrypsin can not activate epithelial PAR-1 , -2 , but weakly activates brain PAR-1 .
17684846	0	met-enkephalin	7,21	beta-endorphin	23,37	met-enkephalin	beta-endorphin	5443	5443	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Plasma met-enkephalin , beta-endorphin and leu-enkephalin levels in human hepatic_encephalopathy .
3995557	0	met-enkephalin	14,28	gastrin	92,99	met-enkephalin	gastrin	5443	2520	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Occurrence of met-enkephalin , met-enkephalin-Arg6-Phe7 and met-enkephalin-Arg6-Gly7-Leu8 in gastrin cells of hog antral mucosa .
21515581	0	metabotropic_glutamate_receptor	4,35	PI3K	63,67	metabotropic glutamate receptor	PI3K	43838(Tax:7227)	33203(Tax:7227)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The metabotropic_glutamate_receptor activates the lipid kinase PI3K in Drosophila motor neurons through the calcium/calmodulin-dependent protein kinase II and the nonreceptor tyrosine protein kinase DFak .
26176806	0	metadherin	86,96	MTDH	98,102	metadherin	MTDH	92140	92140	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin -LRB- MTDH -RRB- expression .
19021535	0	metal-regulatory_transcription_factor_1	35,74	MTF1	76,80	metal-regulatory transcription factor 1	MTF1	195821(Tax:7955)	195821(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Zinc-controlled gene expression by metal-regulatory_transcription_factor_1 -LRB- MTF1 -RRB- in a model vertebrate , the zebrafish .
16619271	0	metal-responsive_transcription_factor-1	8,47	MTF-1	49,54	metal-responsive transcription factor-1	MTF-1	17764(Tax:10090)	17764(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of metal-responsive_transcription_factor-1 -LRB- MTF-1 -RRB- in EGF-dependent DNA synthesis in primary hepatocytes .
16164411	0	metal_responsive_transcription_factor-1	84,123	placenta_growth_factor	42,64	metal responsive transcription factor-1	placenta growth factor	4520	5228	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	NF-kappaB contributes to transcription of placenta_growth_factor and interacts with metal_responsive_transcription_factor-1 in hypoxic human cells .
23891525	0	metallo-b-lactamase	50,69	MBL	71,74	metallo-b-lactamase	MBL	17195(Tax:10090)	17195(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	In vivo efficacy of biapenem with ME1071 , a novel metallo-b-lactamase -LRB- MBL -RRB- inhibitor , in a murine model mimicking ventilator-associated_pneumonia caused by MBL-producing Pseudomonas_aeruginosa .
19770275	0	metallo-beta-lactamase	26,48	NDM-1	59,64	metallo-beta-lactamase	NDM-1	11934636	13914125	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a new metallo-beta-lactamase gene , bla -LRB- NDM-1 -RRB- , and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella_pneumoniae sequence type 14 from India .
3276960	0	metalloendopeptidase	40,60	enkephalinase	16,29	metalloendopeptidase	enkephalinase	64517(Tax:10116)	24590(Tax:10116)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of enkephalinase -LRB- membrane metalloendopeptidase , E.C. 3.4.24.11 -RRB- in rat organs .
18687470	0	metallothionein	27,42	MT	44,46	metallothionein	MT	105931605	105931605	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Differential expression of metallothionein -LRB- MT -RRB- gene by trace metals and endocrine-disrupting chemicals in the hermaphroditic mangrove killifish , Kryptolebias_marmoratus .
19938953	0	metallothionein-1	14,31	MT-1	33,37	metallothionein-1	MT-1	24567(Tax:10116)	24567(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of metallothionein-1 -LRB- MT-1 -RRB- mRNA in the rat testes and liver after cadmium injection .
15369632	0	metallothionein-1F	25,43	MT1F	45,49	metallothionein-1F	MT1F	4494	4494	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The relationship between metallothionein-1F -LRB- MT1F -RRB- gene and hepatocellular_carcinoma .
9372231	0	metallothionein-I	13,30	MT-I	32,36	metallothionein-I	MT-I	24567(Tax:10116)	24567(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Induction of metallothionein-I -LRB- MT-I -RRB- mRNA in primary astrocyte cultures is mediated by hypotonicity and not ethanol -LRB- EtOH -RRB- per se .
17960876	0	metallothionein-I	101,118	mt-I	122,126	metallothionein-I	mt-I	17748(Tax:10090)	17748(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Improving zinc content and antioxidant activity in transgenic tomato plants with expression of mouse metallothionein-I by mt-I gene .
9593981	0	metallothionein-III	84,103	GIF	105,108	metallothionein-III	GIF	17751(Tax:10090)	14603(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Stimulatory effects of 4-methylcatechol , dopamine and levodopa on the expression of metallothionein-III -LRB- GIF -RRB- mRNA in immortalized mouse brain glial cells -LRB- VR-2g -RRB- .
7482533	0	metallothionein-III	27,46	MT-III	48,54	metallothionein-III	MT-III	17751(Tax:10090)	17751(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive expression of metallothionein-III -LRB- MT-III -RRB- , but not MT-I , inhibits growth when cells become zinc deficient .
10218634	0	metallothionein-III	40,59	growth_inhibitory_factor	14,38	metallothionein-III	growth inhibitory factor	4504	4504	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of growth_inhibitory_factor -LRB- metallothionein-III -RRB- mRNA and protein following excitotoxic immature brain_injury .
15735762	0	metallothionein_1G	19,37	VEGF	50,54	metallothionein 1G	VEGF	4495	7422	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Induction of human metallothionein_1G promoter by VEGF and heavy metals : differential involvement of E2F and metal transcription factors .
18237193	0	metallothionein_2	29,46	Transthyretin	0,13	metallothionein 2	Transthyretin	4502	7276	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transthyretin interacts with metallothionein_2 .
12646258	0	metallothionein_2A	103,121	ECRG2	0,5	metallothionein 2A	ECRG2	4502	84651	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ECRG2 , a novel candidate of tumor suppressor gene in the esophageal_carcinoma , interacts directly with metallothionein_2A and links to apoptosis .
8467794	0	metallothionein_I	54,71	MTF-1	28,33	metallothionein I	MTF-1	17748(Tax:10090)	17764(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Cloned transcription factor MTF-1 activates the mouse metallothionein_I promoter .
23291068	0	metastasis-associated_in_colon_cancer_1	41,80	MACC1	82,87	metastasis-associated in colon cancer 1	MACC1	346389	346389	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression and clinical significance of metastasis-associated_in_colon_cancer_1 -LRB- MACC1 -RRB- in HBV-related_hepatocellular_carcinoma -RSB- .
16733204	0	metastasis-associated_protein_1	14,45	MTA1	47,51	metastasis-associated protein 1	MTA1	9112	9112	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of metastasis-associated_protein_1 -LRB- MTA1 -RRB- in benign endometrium and endometrial_adenocarcinomas .
24413532	0	metastasis-associated_protein_1	84,115	estrogen_receptor_a	27,46	metastasis-associated protein 1	estrogen receptor a	9112	2099	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Differential regulation of estrogen_receptor_a expression in breast_cancer cells by metastasis-associated_protein_1 .
25579553	0	metastasis_associated_in_colon_cancer_1	27,66	MACC1	68,73	metastasis associated in colon cancer 1	MACC1	346389	346389	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of metastasis_associated_in_colon_cancer_1 -LRB- MACC1 -RRB- expression in patients with gallbladder_cancer .
17925019	0	metastasis_suppressor_1	81,104	Mtss1	106,111	metastasis suppressor 1	Mtss1	211401(Tax:10090)	211401(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression and differentiation-related neuron-specific splicing of metastasis_suppressor_1 -LRB- Mtss1 -RRB- in normal and transformed cerebellar cells .
17442564	0	metastin	14,22	AXOR12	57,63	metastin	AXOR12	3814	84634	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of metastin and a G-protein-coupled receptor -LRB- AXOR12 -RRB- in epithelial_ovarian_cancer .
17289848	0	metastin	14,22	GPR54	39,44	metastin	GPR54	289023(Tax:10116)	78976(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition of metastin -LRB- kisspeptin-54 -RRB- - GPR54 signaling in the arcuate_nucleus-median eminence region during lactation in rats .
10381257	0	metaxin_2	25,34	Metaxin_1	0,9	metaxin 2	Metaxin 1	10651	4580	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Metaxin_1 interacts with metaxin_2 , a novel related protein associated with the mammalian mitochondrial outer membrane .
15087125	0	metaxin_3	14,23	mtx3	30,34	metaxin 3	mtx3	402916(Tax:7955)	402916(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The zebrafish metaxin_3 gene -LRB- mtx3 -RRB- : cDNA and protein structure , and comparison to zebrafish metaxins_1_and_2 .
21406062	0	methionine_adenosyltransferase_2A	39,72	Insulin-like_growth_factor_1	0,28	methionine adenosyltransferase 2A	Insulin-like growth factor 1	4144	3479	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Insulin-like_growth_factor_1 activates methionine_adenosyltransferase_2A transcription by multiple pathways in human colon_cancer cells .
22542325	0	methionine_adenosyltransferase_II_alpha	18,57	MAT2A	59,64	methionine adenosyltransferase II alpha	MAT2A	4144	4144	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of methionine_adenosyltransferase_II_alpha -LRB- MAT2A -RRB- in gastric_cancer and induction of cell cycle arrest and apoptosis in SGC-7901 cells by shRNA-mediated silencing of MAT2A gene .
24342607	0	methionine_sulfoxide_reductase	10,40	SelR	45,49	methionine sulfoxide reductase	SelR	4552	51734	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effect of methionine_sulfoxide_reductase B1 -LRB- SelR -RRB- gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells .
17519015	0	methionine_sulfoxide_reductase_B1	100,133	MsrB1	135,140	methionine sulfoxide reductase B1	MsrB1	51734	51734	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Important roles of multiple Sp1 binding sites and epigenetic modifications in the regulation of the methionine_sulfoxide_reductase_B1 -LRB- MsrB1 -RRB- promoter .
18980384	0	methionine_synthase_reductase	65,94	FMN	44,47	methionine synthase reductase	FMN	4552	342184	Gene	Gene	mutant|nmod|START_ENTITY mutant|compound|END_ENTITY	Impeded electron transfer from a pathogenic FMN domain mutant of methionine_synthase_reductase and its responsiveness to flavin supplementation .
18515090	0	methionine_synthase_reductase	30,59	MTRR	61,65	methionine synthase reductase	MTRR	4552	4552	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	His595Tyr polymorphism in the methionine_synthase_reductase -LRB- MTRR -RRB- gene is associated with pancreatic_cancer risk .
22106287	0	methionyl-tRNA_synthetase	13,38	aminoacyl-tRNA_synthetase-interacting_multifunctional_protein-3	105,168	methionyl-tRNA synthetase	aminoacyl-tRNA synthetase-interacting multifunctional protein-3	4141	9521	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Dual role of methionyl-tRNA_synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA_synthetase-interacting_multifunctional_protein-3 .
21086164	0	methyl-CpG-binding_domain_protein_2	29,64	miR-373	0,7	methyl-CpG-binding domain protein 2	miR-373	8932	442918	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	miR-373 negatively regulates methyl-CpG-binding_domain_protein_2 -LRB- MBD2 -RRB- in hilar_cholangiocarcinoma .
23591336	0	methyl-CpG-binding_protein_2	28,56	MECP2	58,63	methyl-CpG-binding protein 2	MECP2	4204	4204	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Mutational analysis of the methyl-CpG-binding_protein_2 -LRB- MECP2 -RRB- gene in male autism patients -RSB- .
22207122	0	methyl-CpG-binding_protein_2	72,100	MeCP2	102,107	methyl-CpG-binding protein 2	MeCP2	4204	4204	Gene	Gene	expressions|amod|START_ENTITY expressions|appos|END_ENTITY	Early intervention with psychostimulants or antidepressants to increase methyl-CpG-binding_protein_2 -LRB- MeCP2 -RRB- expressions : a potential therapy for Rett_syndrome .
22822052	0	methyl-CpG-binding_protein_2	35,63	MeCP2	65,70	methyl-CpG-binding protein 2	MeCP2	4204	4204	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Nuclear calcium signaling controls methyl-CpG-binding_protein_2 -LRB- MeCP2 -RRB- phosphorylation on serine 421 following synaptic activity .
22123427	0	methyl-CpG_binding_protein_2	25,53	MECP2	55,60	methyl-CpG binding protein 2	MECP2	4204	4204	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Algorithmic approach for methyl-CpG_binding_protein_2 -LRB- MECP2 -RRB- gene testing in patients with neurodevelopmental_disabilities .
23400946	0	methyl-CpG_binding_protein_2	23,51	MECP2	53,58	methyl-CpG binding protein 2	MECP2	4204	4204	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of methyl-CpG_binding_protein_2 -LRB- MECP2 -RRB- gene in Indian cases of Rett_syndrome .
10196703	0	methylene-tetrahydrofolate_reductase	66,102	MTHFR	109,114	methylene-tetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate_reductase gene -LRB- MTHFR -RRB- .
25299110	0	methylenetetrahydrofolate-reductase	62,97	MTHFR	99,104	methylenetetrahydrofolate-reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ethnic variation of the C677T and A1298C polymorphisms in the methylenetetrahydrofolate-reductase -LRB- MTHFR -RRB- gene in southwestern Mexico .
10462631	0	methylenetetrahydrofolate_reductase	75,110	MTHFR	112,117	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Development of an internal restriction control in the PCR detection of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T mutation .
10666493	0	methylenetetrahydrofolate_reductase	15,50	MTHFR	52,57	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism with bone_mineral_density in postmenopausal Japanese women .
10679944	0	methylenetetrahydrofolate_reductase	47,82	MTHFR	84,89	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of six novel mutations in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in patients with homocystinuria .
10695265	0	methylenetetrahydrofolate_reductase	100,135	MTHFR	137,142	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene -LRB- C677T -RRB- .
10780318	0	methylenetetrahydrofolate_reductase	118,153	MTHFR	155,160	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The role of vitamin_B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene .
10860300	0	methylenetetrahydrofolate_reductase	18,53	MTHFR	55,60	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Apolipoprotein_E , methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- mutation and the risk of senile_dementia -- an epidemiological study using the polymerase chain reaction -LRB- PCR -RRB- method .
11080594	0	methylenetetrahydrofolate_reductase	20,55	MTHFR	57,62	methylenetetrahydrofolate reductase	MTHFR	4524	17769(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	The human and mouse methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- genes : genomic organization , mRNA structure and linkage to the CLCN6 gene .
11142765	0	methylenetetrahydrofolate_reductase	65,100	MTHFR	102,107	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ethnic differences in the frequency of the C677T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in healthy Israeli populations .
11468972	0	methylenetetrahydrofolate_reductase	21,56	MTHFR	63,68	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Polymorphism of the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and incidence of hyperhomocysteinemia-related diseases -RSB- .
11589919	0	methylenetetrahydrofolate_reductase	63,98	MTHFR	100,105	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene : a study in an Italian population with dementia .
11692165	0	methylenetetrahydrofolate_reductase	31,66	MTHFR	68,73	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A second common variant in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and its relationship to MTHFR enzyme activity , homocysteine , and cardiovascular_disease risk .
12027572	0	methylenetetrahydrofolate_reductase	31,66	MTHFR	68,73	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 677C _ -- > _ T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in epileptic patients affected by systemic_lupus_erythematosus .
12540022	0	methylenetetrahydrofolate_reductase	4,39	MTHFR	41,46	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in colorectal_cancer : role in tumor development and significance of allelic loss in tumor progression .
14614398	0	methylenetetrahydrofolate_reductase	44,79	MTHFR	81,86	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prevalence of the C677T substitution of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in Wisconsin .
15040829	0	methylenetetrahydrofolate_reductase	44,79	MTHFR	81,86	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a common polymorphism in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with bone phenotypes depends on plasma folate status .
15114606	0	methylenetetrahydrofolate_reductase	58,93	MTHFR	95,100	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Differences in the frequency of the C677T mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene among the Lebanese population .
15259035	0	methylenetetrahydrofolate_reductase	26,61	MTHFR	63,68	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Metabolic effects and the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism associated with neural_tube_defects in southern Brazil .
16379339	0	methylenetetrahydrofolate_reductase	13,48	MTHFR	50,55	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism , B vitamins and other factors on plasma homocysteine and risk of thromboembolic_disease in Chinese .
16545905	0	methylenetetrahydrofolate_reductase	38,73	MTHFR	75,80	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of 677C > T polymorphism of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with bipolar_disorder and schizophrenia .
16758123	0	methylenetetrahydrofolate_reductase	15,50	MTHFR	52,57	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphisms with genetic susceptibility to gastric_cancer : a meta-analysis .
16832597	0	methylenetetrahydrofolate_reductase	18,53	MTHFR	55,60	methylenetetrahydrofolate reductase	MTHFR	17769(Tax:10090)	17769(Tax:10090)	Gene	Gene	START_ENTITY|dobj|effect effect|appos|END_ENTITY	Folic_acid rivals methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene-silencing effect on MEPM cell proliferation and apoptosis .
16936070	0	methylenetetrahydrofolate_reductase	30,65	MTHFR	72,77	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The C677T polymorphism in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- , maternal use of folic_acid supplements , and risk of isolated_clubfoot : A case-parent-triad analysis .
17111187	0	methylenetetrahydrofolate_reductase	17,52	MTHFR	59,64	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and the age of onset of sporadic_colorectal_adenocarcinoma .
17344026	0	methylenetetrahydrofolate_reductase	15,50	MTHFR	52,57	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Effects of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism on executive function in schizophrenia .
18053312	0	methylenetetrahydrofolate_reductase	21,56	MTHFR	58,63	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene , intakes of folate and related B_vitamins and colorectal_cancer : a case-control study in a population with relatively low folate intake .
18499331	0	methylenetetrahydrofolate_reductase	16,51	MTHFR	53,58	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Carriage of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism does not influence the first and second trimester uterine artery Doppler flow .
18979159	0	methylenetetrahydrofolate_reductase	51,86	MTHFR	88,93	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The synergistic effect of bone mineral density and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism -LRB- C677T -RRB- on fractures .
19421414	0	methylenetetrahydrofolate_reductase	25,60	MTHFR	67,72	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the methylenetetrahydrofolate_reductase gene , MTHFR , does not alter the risk of visual_failure in Leber 's _ hereditary_optic_neuropathy .
19746410	0	methylenetetrahydrofolate_reductase	20,55	MTHFR	57,62	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism and age of onset in schizophrenia .
19846566	0	methylenetetrahydrofolate_reductase	33,68	MTHFR	70,75	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Meta - and pooled analyses of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism and colorectal_cancer : a HuGE-GSEC review .
20692813	0	methylenetetrahydrofolate_reductase	40,75	MTHFR	82,87	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gene-wide association study between the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and schizophrenia in the Japanese population , with an updated meta-analysis on currently available data .
21270470	0	methylenetetrahydrofolate_reductase	8,43	MTHFR	50,55	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- 677C > T polymorphism in pediatric cerebrovascular_disorders .
21334398	0	methylenetetrahydrofolate_reductase	27,62	MTHFR	69,74	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variability in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- affects clinical expression of Wilson 's _ disease .
21506883	0	methylenetetrahydrofolate_reductase	88,123	MTHFR	125,130	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Age at menarche and menopause is not associated with two common genetic variants in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene .
21732284	0	methylenetetrahydrofolate_reductase	46,81	MTHFR	83,88	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Risk of colorectal_cancer associated with the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism in the Kashmiri population .
22103601	0	methylenetetrahydrofolate_reductase	51,86	MTHFR	88,93	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the C677T polymorphism in the human methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with the genetic predisposition for type_2_diabetes_mellitus in a Moroccan population .
22108397	0	methylenetetrahydrofolate_reductase	35,70	MTHFR	72,77	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Comparison of the frequency of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism in depressed versus nondepressed patients .
22492374	0	methylenetetrahydrofolate_reductase	21,56	MTHFR	58,63	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Prospective study of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- variant C677T and risk of all-cause and cardiovascular_disease mortality among 6000 US adults .
22528943	0	methylenetetrahydrofolate_reductase	10,45	MTHFR	47,52	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphisms on methotrexate-induced toxicities in acute_lymphoblastic_leukemia : a meta-analysis .
22846211	0	methylenetetrahydrofolate_reductase	55,90	MTHFR	92,97	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serum homocysteine , vitamin_B12 , folic_acid levels and methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphism in vitiligo .
23161188	0	methylenetetrahydrofolate_reductase	38,73	MTHFR	75,80	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequency of the C677T variant of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in patients with migraine with or without aura - a preliminary report .
24247802	0	methylenetetrahydrofolate_reductase	161,196	MTHFR	198,203	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new and improved method based on polymerase chain reaction-restriction fragment length polymorphism -LRB- PCR-RFLP -RRB- for the determination of A1298C mutation in the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene .
24366618	0	methylenetetrahydrofolate_reductase	55,90	MTHFR	92,97	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of 677C _ > _ T polymorphism a single substitution in methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene in North Indian infertile men .
24472005	0	methylenetetrahydrofolate_reductase	29,64	MTHFR	71,76	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- and risk of vitiligo in Han Chinese populations : a genotype-phenotype correlation study .
25294236	0	methylenetetrahydrofolate_reductase	25,60	MTHFR	62,67	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and susceptibility to depression in Asian population : a systematic meta-analysis .
25412139	0	methylenetetrahydrofolate_reductase	45,80	MTHFR	82,87	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of C677T transition of the human methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene with male_infertility .
25832791	0	methylenetetrahydrofolate_reductase	25,60	MTHFR	62,67	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and susceptibility to depression in Asian population : a systematic meta-analysis .
25887077	0	methylenetetrahydrofolate_reductase	21,56	MTHFR	63,68	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- are associated with susceptibility to adult acute_myeloid_leukemia in a Chinese population .
25887077	0	methylenetetrahydrofolate_reductase	21,56	MTHFR	63,68	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the methylenetetrahydrofolate_reductase gene -LRB- MTHFR -RRB- are associated with susceptibility to adult acute_myeloid_leukemia in a Chinese population .
25966188	0	methylenetetrahydrofolate_reductase	15,50	MTHFR	52,57	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphism with ischemic_stroke in the Eastern Chinese Han population .
26177556	0	methylenetetrahydrofolate_reductase	25,60	MTHFR	62,67	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms of methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene and susceptibility to depression in Asian population : a systematic meta-analysis .
26599798	0	methylenetetrahydrofolate_reductase	72,107	MTHFR	109,114	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Associations between asymmetric_dimethylarginine , homocysteine , and the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T polymorphism -LRB- rs1801133 -RRB- in rheumatoid_arthritis .
26734634	0	methylenetetrahydrofolate_reductase	20,55	MTHFR	57,62	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- polymorphism and carotid intima medial thickness progression in post ischaemic_stroke patient .
8673563	0	methylenetetrahydrofolate_reductase	56,91	MTHFR	93,98	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Distribution in healthy and coronary populations of the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- C677T mutation .
8940272	0	methylenetetrahydrofolate_reductase	41,76	MTHFR	78,83	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Severe and mild mutations in cis for the methylenetetrahydrofolate_reductase -LRB- MTHFR -RRB- gene , and description of five novel mutations in MTHFR .
9409277	0	methylenetetrahydrofolate_reductase	36,71	MTHFR	92,97	methylenetetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Hyperhomocyst -LRB- e -RRB- inemia and a common methylenetetrahydrofolate_reductase mutation -LRB- Ala223Val MTHFR -RRB- in patients with inherited thrombophilic_coagulation_defects .
22380407	0	methylguanine_DNA_methyltransferase	52,87	MGMT	89,93	methylguanine DNA methyltransferase	MGMT	4255	4255	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	A study of clinico-pathological parameters and O - methylguanine_DNA_methyltransferase -LRB- MGMT -RRB- promoter methylation status in the prognostication of gliosarcoma .
16752391	0	methylmalonyl-CoA_epimerase	38,65	MCEE	72,76	methylmalonyl-CoA epimerase	MCEE	84693	84693	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A homozygous nonsense mutation in the methylmalonyl-CoA_epimerase gene -LRB- MCEE -RRB- results in mild methylmalonic_aciduria .
9285782	0	methylmalonyl-CoA_mutase	43,67	mut	91,94	methylmalonyl-CoA mutase	mut	4594	4594	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Expression and kinetic characterization of methylmalonyl-CoA_mutase from patients with the mut - phenotype : evidence for naturally occurring interallelic complementation .
23227498	0	methyltetrahydrofolate_reductase	9,41	MTHFR	43,48	methyltetrahydrofolate reductase	MTHFR	4524	4524	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Role of methyltetrahydrofolate_reductase -LRB- MTHFR -RRB- gene polymorphism in the development of ischemic_stroke in the dwellers of the Kyrgyz Republic -RSB- .
16081515	0	methylthioadenosine_phosphorylase	75,108	MTAP	110,114	methylthioadenosine phosphorylase	MTAP	4507	4507	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine_phosphorylase -LRB- MTAP -RRB- expression in hepatocellular_carcinoma .
19622299	0	methylthioadenosine_phosphorylase	15,48	MTAP	50,54	methylthioadenosine phosphorylase	MTAP	4507	4507	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of methylthioadenosine_phosphorylase -LRB- MTAP -RRB- gene and demethylation of its promoter in human colorectal_cancer -RSB- .
21301207	0	methylthioadenosine_phosphorylase	27,60	MTAP	62,66	methylthioadenosine phosphorylase	MTAP	66902(Tax:10090)	66902(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Targeting tumors that lack methylthioadenosine_phosphorylase -LRB- MTAP -RRB- activity : current strategies .
21356366	0	methylthioadenosine_phosphorylase	19,52	MTAP	54,58	methylthioadenosine phosphorylase	MTAP	4507	4507	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of methylthioadenosine_phosphorylase -LRB- MTAP -RRB- induces progression of hepatocellular_carcinoma via accumulation of 5 ' - deoxy-5 ' - methylthioadenosine -LRB- MTA -RRB- .
11313768	0	mevalonate_kinase	20,37	MVK	39,42	mevalonate kinase	MVK	4598	4598	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Organization of the mevalonate_kinase -LRB- MVK -RRB- gene and identification of novel mutations causing mevalonic_aciduria and hyperimmunoglobulinaemia D and periodic_fever_syndrome .
24084495	0	mevalonate_kinase	17,34	MVK	36,39	mevalonate kinase	MVK	4598	4598	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the mevalonate_kinase -LRB- MVK -RRB- gene cause nonsyndromic retinitis_pigmentosa .
18494797	0	mevalonate_kinase	62,79	luteinizing_hormone_receptor	14,42	mevalonate kinase	luteinizing hormone receptor	81727(Tax:10116)	25477(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of luteinizing_hormone_receptor mRNA expression by mevalonate_kinase -- role of the catalytic center in mRNA recognition .
20044811	0	mga	34,37	gata4	48,53	mga	gata4	23269	2626	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The tbx/bHLH transcription factor mga regulates gata4 and organogenesis .
16137990	0	mgr1	45,49	mass1	51,56	mgr1	mass1	110789(Tax:10090)	110789(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Auditory deficits associated with the frings mgr1 -LRB- mass1 -RRB- mutation in mice .
24798454	0	miR-1	172,177	Androgen_receptor	0,17	miR-1	Androgen receptor	79187	367	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Androgen_receptor -LRB- AR -RRB- inhibitor ErbB3-binding_protein-1 -LRB- Ebp1 -RRB- is not targeted by the newly identified AR controlling signaling axis_heat-shock_protein_HSP27 and microRNA miR-1 in prostate_cancer cells .
25237831	0	miR-1	49,54	Endothelin-1	55,67	miR-1	Endothelin-1	79187	1906	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	EZH2 promotes angiogenesis through inhibition of miR-1 / Endothelin-1 axis in nasopharyngeal_carcinoma .
24798454	0	miR-1	172,177	ErbB3-binding_protein-1	33,56	miR-1	ErbB3-binding protein-1	79187	5036	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Androgen_receptor -LRB- AR -RRB- inhibitor ErbB3-binding_protein-1 -LRB- Ebp1 -RRB- is not targeted by the newly identified AR controlling signaling axis_heat-shock_protein_HSP27 and microRNA miR-1 in prostate_cancer cells .
17401374	0	miR-1	29,34	GJA1	91,95	miR-1	GJA1	100314077(Tax:10116)	24392(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 .
24982356	0	miR-1	45,50	HSPB1	19,24	miR-1	HSPB1	79187	3315	Gene	Gene	expression|amod|START_ENTITY attenuates|dobj|expression attenuates|nsubj|END_ENTITY	Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate_cancer cells .
20655308	0	miR-1	0,5	Hsp60	23,28	miR-1	Hsp60	79187	3329	Gene	Gene	START_ENTITY|appos|contributing contributing|nsubj|expression expression|amod|END_ENTITY	miR-1 / miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes .
26926567	0	miR-1	92,97	MALAT1	0,6	miR-1	MALAT1	79187	378938	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	MALAT1 induced migration and invasion of human breast_cancer cells by competitively binding miR-1 with cdc42 .
19245789	0	miR-1	26,31	miR-206	32,39	miR-1	miR-206	100314077(Tax:10116)	100314052(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Upregulated expression of miR-1 / miR-206 in a rat model of myocardial_infarction .
20655308	0	miR-1	0,5	miR-206	6,13	miR-1	miR-206	79187	406989	Gene	Gene	START_ENTITY|appos|contributing contributing|nsubj|expression expression|amod|END_ENTITY	miR-1 / miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes .
22926517	0	miR-100	0,7	IGF2	19,23	miR-100	IGF2	406892	3481	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling .
26409044	0	miR-100	0,7	mTOR	19,23	miR-100	mTOR	100314234(Tax:10116)	21977(Tax:10090)	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	miR-100 suppresses mTOR signaling in hypoxia-induced pulmonary_hypertension in rats .
26556718	0	miR-101	66,73	Cyclooxygenase-2	0,16	miR-101	Cyclooxygenase-2	387143(Tax:10090)	5743	Gene	Gene	Regulated|nmod|START_ENTITY Regulated|nsubjpass|END_ENTITY	Cyclooxygenase-2 , a Potential Therapeutic Target , Is Regulated by miR-101 in Esophageal_Squamous_Cell_Carcinoma .
25230316	0	miR-101	0,7	Kruppel-like_Factor_6	48,69	miR-101	Kruppel-like Factor 6	387143(Tax:10090)	1316	Gene	Gene	Acts|amod|START_ENTITY Acts|nmod|END_ENTITY	miR-101 Acts as a Tumor Suppressor by Targeting Kruppel-like_Factor_6 in Glioblastoma Stem Cells .
26097565	0	miR-106a	0,8	PTEN	83,87	miR-106a	PTEN	406899	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-106a promotes growth and metastasis of non-small_cell_lung_cancer by targeting PTEN .
26191213	0	miR-107	0,7	Axin2	74,79	miR-107	Axin2	406901	8313	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	miR-107 promotes hepatocellular_carcinoma cell proliferation by targeting Axin2 .
25068583	0	miR-10a	0,7	GATA6	85,90	miR-10a	GATA6	406902	2627	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-10a regulates proliferation of human cardiomyocyte progenitor cells by targeting GATA6 .
26772886	0	miR-1182	0,8	hTERT	90,95	miR-1182	hTERT	100302132	7015	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-1182 inhibits growth and mediates the chemosensitivity of bladder_cancer by targeting hTERT .
24244539	0	miR-122	0,7	AKT3	73,77	miR-122	AKT3	387231(Tax:10090)	23797(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-122 regulates tumorigenesis in hepatocellular_carcinoma by targeting AKT3 .
21241755	0	miR-122	31,38	HNF4a	53,58	miR-122	HNF4a	387231(Tax:10090)	15378(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Positive regulation of hepatic miR-122 expression by HNF4a .
22190517	0	miR-122	14,21	IFN-a	25,30	miR-122	IFN-a	406906	3438	Gene	Gene	START_ENTITY|nmod|treatment treatment|amod|END_ENTITY	-LSB- Influence of miR-122 on IFN-a treatment for HCV_infection -RSB- .
26125464	0	miR-122	0,7	LH_Receptor	18,29	miR-122	LH Receptor	100314023(Tax:10116)	25477(Tax:10116)	Gene	Gene	Expression|amod|START_ENTITY Expression|compound|END_ENTITY	miR-122 Regulates LH_Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries .
24064360	0	miR-122	50,57	LH_receptor	14,25	miR-122	LH receptor	100314023(Tax:10116)	25477(Tax:10116)	Gene	Gene	mRNA|advcl|START_ENTITY mRNA|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of LH_receptor mRNA binding protein by miR-122 in rat ovaries .
25472877	0	miR-122	71,78	MEF2D	89,94	miR-122	MEF2D	406906	4209	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Oleanolic_acid suppresses the proliferation of lung_carcinoma cells by miR-122 / Cyclin_G1 / MEF2D axis .
23872065	0	miR-122	0,7	NOD2	16,20	miR-122	NOD2	406906	64127	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn 's _ disease .
26546436	0	miR-122	0,7	PKM2	53,57	miR-122	PKM2	406906	5315	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-122 inhibits cancer_cell_malignancy by targeting PKM2 in gallbladder_carcinoma .
21320120	0	miR-1224	27,35	Sp1	112,115	miR-1224	Sp1	100316739(Tax:10090)	20683(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Lipopolysaccharide-induced miR-1224 negatively regulates tumour_necrosis_factor-a gene expression by modulating Sp1 .
21320120	0	miR-1224	27,35	tumour_necrosis_factor-a	57,81	miR-1224	tumour necrosis factor-a	100316739(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Lipopolysaccharide-induced miR-1224 negatively regulates tumour_necrosis_factor-a gene expression by modulating Sp1 .
17616664	0	miR-122a	25,33	Cyclin_G1	0,9	miR-122a	Cyclin G1	406906	900	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Cyclin_G1 is a target of miR-122a , a microRNA frequently down-regulated in human hepatocellular_carcinoma .
26189214	0	miR-1238	0,8	LHX2	50,54	miR-1238	LHX2	100302226	9355	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-1238 inhibits cell proliferation by targeting LHX2 in non-small_cell_lung_cancer .
26355845	0	miR-1244	0,8	Myocyte_Enhancer_Factor_2D	9,35	miR-1244	Myocyte Enhancer Factor 2D	100302285	4209	Gene	Gene	Loop|amod|START_ENTITY Loop|compound|END_ENTITY	miR-1244 / Myocyte_Enhancer_Factor_2D Regulatory Loop Contributes to the Growth_of_Lung_Carcinoma .
24739954	0	miR-1246	109,117	DLG3	138,142	miR-1246	DLG3	100302142	1741	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression .
24690917	0	miR-125a	18,26	CD34	55,59	miR-125a	CD34	406910	947	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Overexpression of miR-125a in myelodysplastic_syndrome CD34 + cells modulates NF-kB activation and enhances erythroid differentiation arrest .
21658607	0	miR-125a	52,60	FMRP	62,66	miR-125a	FMRP	406910	2332	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Reversible inhibition of PSD-95 mRNA translation by miR-125a , FMRP phosphorylation , and mGluR signaling .
26398444	0	miR-125a	0,8	vascular_endothelial_growth_factor_A	63,99	miR-125a	vascular endothelial growth factor A	406910	7422	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-125a regulates angiogenesis of gastric_cancer by targeting vascular_endothelial_growth_factor_A .
20034472	0	miR-126	0,7	EGFL7	77,82	miR-126	EGFL7	406913	678640(Tax:7955)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-126 inhibits non-small cell lung_cancer cells proliferation by targeting EGFL7 .
26239517	0	miR-126	0,7	LRP6	65,69	miR-126	LRP6	406913	4040	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-126 inhibits papillary_thyroid_carcinoma growth by targeting LRP6 .
21439283	0	miR-126	0,7	SLC7A5	76,82	miR-126	SLC7A5	406913	8140	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-126 inhibits proliferation of small_cell_lung_cancer cells by targeting SLC7A5 .
24384842	0	miR-126	0,7	Sox2	69,73	miR-126	Sox2	406913	6657	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	miR-126 functions as a tumor suppressor in osteosarcoma by targeting Sox2 .
25585946	0	miR-126	0,7	Sox2	120,124	miR-126	Sox2	406913	6657	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	miR-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular_carcinoma cells partially by targeting Sox2 .
26956185	0	miR-126	127,134	VEGFR2	135,141	miR-126	VEGFR2	406913	3791	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The effects of microvesicles on endothelial progenitor cells are compromised in type 2 diabetic patients via downregulation of miR-126 / VEGFR2 pathway .
25205714	0	miR-126	0,7	platelet-derived_growth_factor_receptor-a	18,59	miR-126	platelet-derived growth factor receptor-a	406913	5156	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	miR-126 regulates platelet-derived_growth_factor_receptor-a expression and migration of primary human osteoblasts .
24282530	0	miR-127	0,7	BCL6	65,69	miR-127	BCL6	406914	604	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-127 regulates cell proliferation and senescence by targeting BCL6 .
25997961	0	miR-1271	0,8	ALK	63,66	miR-1271	ALK	100302203	238	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-1271 inhibits OSCC cell growth and metastasis by targeting ALK .
24875127	0	miR-1271	0,8	IGF1R	88,93	miR-1271	IGF1R	100302203	3480	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-1271 regulates cisplatin resistance of human gastric_cancer cell lines by targeting IGF1R , IRS1 , mTOR , and BCL2 .
26940738	0	miR-1271	0,8	ZEB1	89,93	miR-1271	ZEB1	100302203	6935	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-1271 inhibits migration , invasion and epithelial-mesenchymal transition by targeting ZEB1 and TWIST1 in pancreatic_cancer cells .
26884980	0	miR-129-5p	30,40	EMT	59,62	miR-129-5p	EMT	100302178	3702	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	MicroRNA profiling identifies miR-129-5p as a regulator of EMT in tubular epithelial cells .
26324125	0	miR-1291	0,8	mucin_1	17,24	miR-1291	mucin 1	406917	4582	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-1291 targets mucin_1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma .
26324125	0	miR-1291	0,8	mucin_1	17,24	miR-1291	mucin 1	406917	4582	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-1291 targets mucin_1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma .
22995297	0	miR-1297	0,8	PTEN	18,22	miR-1297	PTEN	100302187	5728	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	miR-1297 mediates PTEN expression and contributes to cell progression in LSCC .
26573160	0	miR-130a	20,28	NRP1	0,4	miR-130a	NRP1	406919	8829	Gene	Gene	targeted|advcl|START_ENTITY targeted|nsubjpass|END_ENTITY	NRP1 is targeted by miR-130a and miR-130b , and is associated with multidrug resistance in epithelial_ovarian_cancer based on integrated gene network analysis .
24885472	0	miR-130a	16,24	TNF-a	33,38	miR-130a	TNF-a	406919	7124	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	NF-kB-modulated miR-130a targets TNF-a in cervical_cancer cells .
26902120	0	miR-130b	0,8	NKD2	17,21	miR-130b	NKD2	406920	85409	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis in osteosarcoma cells .
26218441	0	miR-132	13,20	Glucagon-Like_Peptide_1	47,70	miR-132	Glucagon-Like Peptide 1	406921	2641	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Induction of miR-132 and miR-212 Expression by Glucagon-Like_Peptide_1 -LRB- GLP-1 -RRB- in Rodent and Human Pancreatic b-Cells .
25983322	0	miR-132	14,21	TGF-b	0,5	miR-132	TGF-b	406921	7040	Gene	Gene	induced|xcomp|START_ENTITY END_ENTITY|acl|induced	TGF-b induced miR-132 enhances the activation of TGF-b signaling through inhibiting SMAD7 expression in glioma cells .
24914372	0	miR-132	0,7	ZEB2	82,86	miR-132	ZEB2	406921	9839	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-132 inhibits colorectal_cancer_invasion and metastasis via directly targeting ZEB2 .
21769867	0	miR-133a	51,59	collagen_1A1	19,31	miR-133a	collagen 1A1	100314030(Tax:10116)	29393(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	MiR-133a regulates collagen_1A1 : potential role of miR-133a in myocardial_fibrosis in angiotensin_II-dependent hypertension .
26945106	0	miR-133b	0,8	Connective_Tissue_Growth_Factor	23,54	miR-133b	Connective Tissue Growth Factor	100314078(Tax:10116)	64032(Tax:10116)	Gene	Gene	Regulation|amod|START_ENTITY Regulation|nmod|END_ENTITY	miR-133b Regulation of Connective_Tissue_Growth_Factor : A Novel Mechanism in Liver Pathology .
26276722	0	miR-133b	74,82	a-3p	83,87	miR-133b	a-3p	442890	10312	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	Identification of miRNomes in human stomach and gastric_carcinoma reveals miR-133b / a-3p as therapeutic target for gastric_cancer .
26870245	0	miR-135b	0,8	STAT6	68,73	miR-135b	STAT6	442891	6778	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-135b inhibits tumour metastasis in prostate_cancer by targeting STAT6 .
20473940	0	miR-137	0,7	Cdc42	16,21	miR-137	Cdc42	406928	998	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-137 targets Cdc42 expression , induces cell cycle G1 arrest and inhibits invasion in colorectal_cancer cells .
23178712	0	miR-137	0,7	Cdc42	69,74	miR-137	Cdc42	406928	998	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-137 inhibits the proliferation of lung_cancer cells by targeting Cdc42 and Cdk6 .
25724519	0	miR-137	0,7	MCL-1	78,83	miR-137	MCL-1	406928	4170	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|nmod|END_ENTITY	miR-137 and miR-197 Induce Apoptosis and Suppress Tumorigenicity by Targeting MCL-1 in Multiple_Myeloma .
24275578	0	miR-137	39,46	MIR137	0,6	miR-137	MIR137	406928	406928	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese .
26186482	0	miR-137	0,7	PAK2	62,66	miR-137	PAK2	406928	5062	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-137 inhibits proliferation of melanoma cells by targeting PAK2 .
26832795	0	miR-137	13,20	Sp1	64,67	miR-137	Sp1	406928	6667	Gene	Gene	Protein|amod|START_ENTITY Protein|compound|END_ENTITY	Induction of miR-137 by Isorhapontigenin -LRB- ISO -RRB- Directly Targets Sp1 Protein Translation and Mediates Its Anticancer Activity Both In Vitro and In Vivo .
23934188	0	miR-137	0,7	constitutive_androstane_receptor	22,54	miR-137	constitutive androstane receptor	406928	9970	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	miR-137 regulates the constitutive_androstane_receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells .
26868851	0	miR-139	0,7	IGF-1_R	84,91	miR-139	IGF-1 R	387157(Tax:10090)	16001(Tax:10090)	Gene	Gene	Functions|amod|START_ENTITY Functions|nmod|END_ENTITY	miR-139 Functions as An Antioncomir to Repress Glioma_Progression Through Targeting IGF-1_R , AMY-1 , and PGC-1b .
21159815	0	miR-14	11,17	insulin	28,35	miR-14	insulin	12798384	42549(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	Drosophila miR-14 regulates insulin production and metabolism through its target , sugarbabe .
19948051	0	miR-140	60,67	IGFBP-5	18,25	miR-140	IGFBP-5	406932	3488	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes .
26459763	0	miR-140	0,7	NEAT1	51,56	miR-140	NEAT1	387158(Tax:10090)	66961(Tax:10090)	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	miR-140 Promotes Expression of long non-coding RNA NEAT1 in Adipogenesis .
24647573	0	miR-141	0,7	EphA2	95,100	miR-141	EphA2	406933	1969	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	miR-141 is a key regulator of renal_cell_carcinoma proliferation and metastasis by controlling EphA2 expression .
24616104	0	miR-141	56,63	HOTAIR	20,26	miR-141	HOTAIR	406933	100124700	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells .
25008569	0	miR-141	0,7	ZEB2	16,20	miR-141	ZEB2	406933	9839	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-141 targets ZEB2 to suppress HCC progression .
22314666	0	miR-141	0,7	androgen_receptor	18,35	miR-141	androgen receptor	406933	367	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	miR-141 modulates androgen_receptor transcriptional activity in human prostate_cancer cells through targeting the small_heterodimer_partner protein .
24424572	0	miR-141	17,24	miR-200c	8,16	miR-141	miR-200c	406933	406985	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of miR-200c / miR-141 in the regulation of epithelial-mesenchymal transition and migration in head_and_neck_squamous_cell_carcinoma .
25815280	0	miR-141	14,21	miR-200c	23,31	miR-141	miR-200c	406933	406985	Gene	Gene	miR-30b|amod|START_ENTITY miR-30b|amod|END_ENTITY	Evaluation of miR-141 , miR-200c , miR-30b Expression and Clinicopathological Features of Bladder_Cancer .
25252191	0	miR-141	25,32	miR-21	17,23	miR-141	miR-21	406933	406991	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Investigation of miR-21 , miR-141 , and miR-221 expression levels in prostate_adenocarcinoma for associated risk of recurrence after radical prostatectomy .
25530132	0	miR-142	0,7	Rac1	75,79	miR-142	Rac1	406934	5879	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	miR-142 acts as a tumor suppressor in osteosarcoma cell lines by targeting Rac1 .
23932921	0	miR-143	43,50	DDX6	0,4	miR-143	DDX6	406935	1656	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	DDX6 post-transcriptionally down-regulates miR-143 / 145 expression through host gene NCR143/145 in cancer cells .
26758433	0	miR-143	0,7	FAM83F	48,54	miR-143	FAM83F	406935	113828	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-143 inhibits tumor progression by targeting FAM83F in esophageal_squamous_cell_carcinoma .
21685392	0	miR-143	4,11	Jagged-1	61,69	miR-143	Jagged-1	406935	182	Gene	Gene	START_ENTITY|dep|target target|nmod|END_ENTITY	The miR-143 / 145 cluster is a novel transcriptional target of Jagged-1 / Notch signaling in vascular smooth muscle cells .
25915937	0	miR-143	76,83	MYH7	91,95	miR-143	MYH7	406935	4625	Gene	Gene	START_ENTITY|nmod|Gene Gene|compound|END_ENTITY	MicroRNA Transcriptome Profile Analysis in Porcine Muscle and the Effect of miR-143 on the MYH7 Gene and Protein .
25915937	0	miR-143	76,83	MYH7	91,95	miR-143	MYH7	406935	4625	Gene	Gene	START_ENTITY|nmod|Gene Gene|compound|END_ENTITY	MicroRNA Transcriptome Profile Analysis in Porcine Muscle and the Effect of miR-143 on the MYH7 Gene and Protein .
27081712	0	miR-143	0,7	NUAK2	47,52	miR-143	NUAK2	406935	81788	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	miR-143 inhibits oncogenic traits by degrading NUAK2 in glioblastoma .
26722463	0	miR-143	0,7	TLR2	23,27	miR-143	TLR2	406935	7097	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	miR-143 down-regulates TLR2 expression in hepatoma cells and inhibits hepatoma cell proliferation and invasion .
25273883	0	miR-143	49,56	angiotensin_converting_enzyme	13,42	miR-143	angiotensin converting enzyme	387161(Tax:10090)	11421(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of angiotensin_converting_enzyme after miR-143 / 145 deletion is critical for impaired smooth muscle contractility .
22354042	0	miR-143	16,23	hexokinase_2	66,78	miR-143	hexokinase 2	406935	3099	Gene	Gene	controls|amod|START_ENTITY glycolysis|nsubj|controls glycolysis|advcl|regulating regulating|dobj|END_ENTITY	A novel miR-155 / miR-143 cascade controls glycolysis by regulating hexokinase_2 in breast_cancer cells .
22469988	0	miR-143	0,7	hexokinase_2	18,30	miR-143	hexokinase 2	406935	3099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	miR-143 regulates hexokinase_2 expression in cancer cells .
22593586	0	miR-143	14,21	hexokinase_2	65,77	miR-143	hexokinase 2	406935	3099	Gene	Gene	MicroRNA-143|dep|START_ENTITY regulates|nsubj|MicroRNA-143 regulates|dobj|glycolysis glycolysis|acl|targeting targeting|dobj|gene gene|amod|END_ENTITY	MicroRNA-143 -LRB- miR-143 -RRB- regulates cancer glycolysis via targeting hexokinase_2 gene .
26988859	0	miR-143	4,11	miR-145	12,19	miR-143	miR-145	406935	406937	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	The miR-143 / miR-145 cluster and the tumor microenvironment : unexpected roles .
22997891	0	miR-143	45,52	miR-373	54,61	miR-143	miR-373	406935	442918	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Differential expression of miR-21 , miR-126 , miR-143 , miR-373 in normal cervical tissue , cervical_cancer tissue and Hela cell -RSB- .
21915288	0	miR-143	0,7	prostaglandin-endoperoxidase_synthase_2	22,61	miR-143	prostaglandin-endoperoxidase synthase 2	406935	5743	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	miR-143 regulation of prostaglandin-endoperoxidase_synthase_2 in the amnion : implications for human parturition at term .
25652854	0	miR-144	1,8	Atg4a	69,74	miR-144	Atg4a	387162(Tax:10090)	666468(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	-LSB- miR-144 regulates BCG - and rapamycin-induced autophagy by targeting Atg4a in RAW264 .7 cells -RSB- .
26097586	0	miR-144	0,7	transforming_growth_factor-b1	18,47	miR-144	transforming growth factor-b1	406936	7040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	miR-144 regulates transforming_growth_factor-b1 iduced hepatic stellate cell activation in human fibrotic liver .
23480797	0	miR-145	47,54	ERG	19,22	miR-145	ERG	406937	2078	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The proto-oncogene ERG is a target of microRNA miR-145 in prostate_cancer .
25609710	0	miR-145	0,7	IGF1R	101,106	miR-145	IGF1R	406937	3480	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|modulating modulating|dobj|END_ENTITY	miR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R .
22869051	0	miR-145	25,32	NEDD9	0,5	miR-145	NEDD9	406937	4739	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	NEDD9 , a novel target of miR-145 , increases the invasiveness of glioblastoma .
26636540	0	miR-145	66,73	Nanog	37,42	miR-145	Nanog	406937	79923	Gene	Gene	sponging|xcomp|START_ENTITY regulate|advcl|sponging regulate|dobj|expression expression|compound|END_ENTITY	ROR functions as a ceRNA to regulate Nanog expression by sponging miR-145 and predicts poor prognosis in pancreatic_cancer .
24954107	0	miR-145	0,7	PAK1	63,67	miR-145	PAK1	406937	5058	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-145 inhibits invasion of bladder_cancer cells by targeting PAK1 .
24846918	0	miR-145	12,19	PC3	69,72	miR-145	PC3	406937	57332	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	-LSB- Effects of miR-145 on the migration and invasion of prostate_cancer PC3 cells by targeting DAB2 -RSB- .
24573110	0	miR-145	25,32	ROCK1	0,5	miR-145	ROCK1	406937	6093	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	ROCK1 , a novel target of miR-145 , promotes glioma_cell_invasion .
19360360	0	miR-145	0,7	RTKN	51,55	miR-145	RTKN	406937	6242	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	miR-145 inhibits breast_cancer cell growth through RTKN .
25145279	0	miR-145	37,44	SOX9	29,33	miR-145	SOX9	406937	6662	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The epigenetic regulation of SOX9 by miR-145 in human chondrosarcoma .
25578496	0	miR-145	0,7	Smad3	63,68	miR-145	Smad3	406937	4088	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-145 inhibits invasion and metastasis by directly targeting Smad3 in nasopharyngeal_cancer .
23886710	0	miR-145	0,7	Sp7	59,62	miR-145	Sp7	387163(Tax:10090)	170574(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	miR-145 suppresses osteogenic differentiation by targeting Sp7 .
21762377	0	miR-145	0,7	TGF-b1	39,45	miR-145	TGF-b1	406937	7040	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	miR-145 is differentially regulated by TGF-b1 and ischaemia and targets Disabled-2 expression and wnt/b-catenin activity .
19730444	0	miR-145	0,7	TP53	26,30	miR-145	TP53	406937	7157	Gene	Gene	participates|nsubj|START_ENTITY participates|nmod|END_ENTITY	miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen_receptor-alpha in human breast_cancer cells .
25969144	0	miR-145	0,7	androgen_receptor	21,38	miR-145	androgen receptor	406937	367	Gene	Gene	suppress|nsubj|START_ENTITY suppress|dobj|END_ENTITY	miR-145 suppress the androgen_receptor in prostate_cancer cells and correlates to prostate_cancer prognosis .
25969144	0	miR-145	0,7	androgen_receptor	21,38	miR-145	androgen receptor	406937	367	Gene	Gene	suppress|nsubj|START_ENTITY suppress|dobj|END_ENTITY	miR-145 suppress the androgen_receptor in prostate_cancer cells and correlates to prostate_cancer prognosis .
19202062	0	miR-145	62,69	c-Myc	14,19	miR-145	c-Myc	406937	4609	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	p53 represses c-Myc through induction of the tumor suppressor miR-145 .
26988859	0	miR-145	12,19	miR-143	4,11	miR-145	miR-143	406937	406935	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	The miR-143 / miR-145 cluster and the tumor microenvironment : unexpected roles .
25661834	0	miR-146a	48,56	CD4	66,69	miR-146a	CD4	406938	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Mycophenolic_acid upregulates miR-142-3P / 5P and miR-146a in lupus CD4 + T cells .
25767384	0	miR-146a	46,54	COX-2	58,63	miR-146a	COX-2	406938	4513	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic_obstructive_pulmonary_disease .
20023696	0	miR-146a	135,143	CXCR4	102,107	miR-146a	CXCR4	406938	7852	Gene	Gene	upregulating|xcomp|START_ENTITY suppresses|advcl|upregulating suppresses|dobj|expression expression|compound|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus-encoded viral FLICE inhibitory protein -LRB- vFLIP -RRB- K13 suppresses CXCR4 expression by upregulating miR-146a .
25705792	0	miR-146a	0,8	CXCR4	18,23	miR-146a	CXCR4	406938	7852	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	miR-146a controls CXCR4 expression in a pathway that involves PLZF and can be used to inhibit HIV-1_infection of CD4 -LRB- + -RRB- T lymphocytes .
26095299	0	miR-146a	114,122	CXCR4	0,5	miR-146a	CXCR4	406938	7852	Gene	Gene	activity|amod|START_ENTITY regulating|dobj|activity functions|acl|regulating functions|nummod|3 3|compound|END_ENTITY	CXCR4 3 ` UTR functions as a ceRNA in promoting metastasis , proliferation and survival of MCF-7 cells by regulating miR-146a activity .
21557898	0	miR-146a	11,19	IL-18	23,28	miR-146a	IL-18	387164(Tax:10090)	16173(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effect of miR-146a on IL-18 expression in mouse macrophage -RSB- .
23509825	0	miR-146a	85,93	Let-7i	70,76	miR-146a	Let-7i	406938	406891	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Helminth excreted/secreted antigens repress expression of LPS-induced Let-7i but not miR-146a and miR-155 in human dendritic cells .
25214035	0	miR-146a	0,8	Rac1	73,77	miR-146a	Rac1	406938	5879	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	miR-146a functions as a tumor suppressor in prostate_cancer by targeting Rac1 .
24472607	0	miR-146a	48,56	RelB	24,28	miR-146a	RelB	406938	5971	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	The NF-kB family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts .
25607648	0	miR-146a	0,8	STAT3	34,39	miR-146a	STAT3	406938	6774	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	miR-146a is directly regulated by STAT3 in human hepatocellular_carcinoma cells and involved in anti-tumor immune suppression .
22507670	0	miR-146a	0,8	Smad4	119,124	miR-146a	Smad4	100314241(Tax:10116)	50554(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	miR-146a , an IL-1b responsive miRNA , induces vascular_endothelial_growth_factor and chondrocyte apoptosis by targeting Smad4 .
23982143	0	miR-146a	23,31	UHRF1	14,19	miR-146a	UHRF1	406938	29128	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of UHRF1 by miR-146a / b modulates gastric_cancer invasion and metastasis .
18347435	0	miR-146a	108,116	latent_membrane_protein_1	27,52	miR-146a	latent membrane protein 1	406938	9260	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Epstein-Barr_virus-encoded latent_membrane_protein_1 -LRB- LMP1 -RRB- induces the expression of the cellular microRNA miR-146a .
27063128	0	miR-146a	23,31	miR-155	14,21	miR-146a	miR-155	406938	406947	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Detection of miR-155 , miR-146a in PBNCs and tissues from patients with oral_lichen_planus -RSB- .
24473196	0	miR-146b	19,27	STAT3	0,5	miR-146b	STAT3	574447	6774	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-kB to IL-6 signaling axis and STAT3-driven cancer phenotypes .
22570175	0	miR-146b	80,88	TGF-b	14,19	miR-146b	TGF-b	100314121(Tax:10116)	59086(Tax:10116)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Growth_factor TGF-b induces intestinal epithelial cell -LRB- IEC-6 -RRB- differentiation : miR-146b as a regulatory component in the negative feedback loop .
23543665	0	miR-146b	17,25	miR-200b	49,57	miR-146b	miR-200b	100314121(Tax:10116)	100314050(Tax:10116)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells .
25399950	0	miR-148a	21,29	SCRN1	50,55	miR-148a	SCRN1	406940	9805	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A genetic variant of miR-148a binding site in the SCRN1 3 ' - UTR is associated with susceptibility and prognosis of gastric_cancer .
25486906	0	miR-148a	0,8	Twist1	27,33	miR-148a	Twist1	387166(Tax:10090)	22160(Tax:10090)	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim .
23171948	0	miR-148b	0,8	AMPKa1	75,81	miR-148b	AMPKa1	442892	5562	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	miR-148b functions as a tumor suppressor in pancreatic_cancer by targeting AMPKa1 .
25232379	0	miR-148b	0,8	carcinoembryonic_antigen	84,108	miR-148b	carcinoembryonic antigen	442892	1084	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	miR-148b functions as a tumor suppressor in non-small_cell_lung_cancer by targeting carcinoembryonic_antigen -LRB- CEA -RRB- .
24632606	0	miR-148b	26,34	p53	8,11	miR-148b	p53	442892	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal_cancer .
24641842	0	miR-149	22,29	interleukin-6	33,46	miR-149	interleukin-6	406941	3569	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Regulatory effect of miR-149 on interleukin-6 expression in silica-induced pulmonary_fibrosis -RSB- .
21551231	0	miR-150	86,93	NOTCH3	76,82	miR-150	NOTCH3	406942	4854	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Modulation of microRNA expression in human T-cell development : targeting of NOTCH3 by miR-150 .
24312495	0	miR-150	0,7	P2X7_receptor	109,122	miR-150	P2X7 receptor	406942	5027	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-150 promotes human breast_cancer growth and malignant behavior by targeting the pro-apoptotic purinergic P2X7_receptor .
23747308	0	miR-150	0,7	P53	69,72	miR-150	P53	406942	7157	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-150 promotes the proliferation of lung_cancer cells by targeting P53 .
18667440	0	miR-150	35,42	c-Myb	0,5	miR-150	c-Myb	100033674(Tax:7955)	30519(Tax:7955)	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	c-Myb is an evolutionary conserved miR-150 target and miR-150 / c-Myb interaction is important for embryonic development .
24915805	0	miR-150	135,142	miR-223	144,151	miR-150	miR-223	100314158(Tax:10116)	100314060(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effects of 5,14-HEDGE , a 20-HETE mimetic , on lipopolysaccharide-induced changes in MyD88/TAK1/IKKb / IkB-a/NF-kB pathway and circulating miR-150 , miR-223 , and miR-297 levels in a rat model of septic_shock .
23670238	0	miR-150	0,7	p53	9,12	miR-150	p53	406942	7157	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	miR-150 , p53 protein and relevant miRNAs consist of a regulatory network in NSCLC_tumorigenesis .
23591597	0	miR-154	0,7	HMGA2	34,39	miR-154	HMGA2	406946	8091	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-154 inhibits EMT by targeting HMGA2 in prostate_cancer cells .
21771600	0	miR-155	14,21	AGTR1	38,43	miR-155	AGTR1	406947	185	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A polymorphic miR-155 binding site in AGTR1 is associated with cardiac_hypertrophy in Friedreich_ataxia .
25929465	0	miR-155	13,20	CD1d	54,58	miR-155	CD1d	387173(Tax:10090)	12479(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	TLR9-induced miR-155 and Ets-1 decrease expression of CD1d on B cells in SLE .
19777054	0	miR-155	0,7	CD4	30,33	miR-155	CD4	387173(Tax:10090)	12504(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY sensitizes|nsubj|inhibition sensitizes|dobj|cells cells|nummod|END_ENTITY	miR-155 inhibition sensitizes CD4 + Th cells for TREG mediated suppression .
25760478	0	miR-155	16,23	CD4	27,30	miR-155	CD4	406947	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Upregulation of miR-155 in CD4 -LRB- + -RRB- T Cells Promoted Th1 Bias in Patients with Unstable_Angina .
26574931	0	miR-155	0,7	Caspase-3	16,25	miR-155	Caspase-3	387173(Tax:10090)	12367(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-155 targets Caspase-3 mRNA in activated macrophages .
24793496	0	miR-155	0,7	E2F2	94,98	miR-155	E2F2	406947	1870	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-155 regulates the proliferation and cell cycle of colorectal_carcinoma cells by targeting E2F2 .
26967247	0	miR-155	0,7	E2F2	103,107	miR-155	E2F2	406947	1870	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-155 regulates the proliferation and invasion of clear_cell_renal_cell_carcinoma cells by targeting E2F2 .
27065318	0	miR-155	0,7	ErbB2	22,27	miR-155	ErbB2	406947	2064	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	miR-155 downregulates ErbB2 and suppresses ErbB2-induced malignant transformation of breast epithelial cells .
21706480	0	miR-155	12,19	FADD	107,111	miR-155	FADD	406947	8772	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Deregulated miR-155 promotes Fas-mediated apoptosis in human intervertebral_disc_degeneration by targeting FADD and caspase-3 .
22096245	0	miR-155	0,7	HGAL	18,22	miR-155	HGAL	406947	257144	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	miR-155 regulates HGAL expression and increases lymphoma_cell_motility .
20444872	0	miR-155	16,23	HOXA9	0,5	miR-155	HOXA9	387173(Tax:10090)	15405(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	HOXA9 regulates miR-155 in hematopoietic cells .
21982894	0	miR-155	31,38	Heme_oxygenase_1	0,16	miR-155	Heme oxygenase 1	406947	3162	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Heme_oxygenase_1 is induced by miR-155 via reduced BACH1 translation in endothelial cells .
22378844	0	miR-155	0,7	IFN-y	18,23	miR-155	IFN-y	406947	3458	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	miR-155 regulates IFN-y production in natural killer cells .
26722313	0	miR-155	82,89	IGFBP-3	71,78	miR-155	IGFBP-3	406947	3486	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Transcriptional activation of the IGF-II/IGF -1 R axis and inhibition of IGFBP-3 by miR-155 in hepatocellular_carcinoma .
20435894	0	miR-155	15,22	IL-10	0,5	miR-155	IL-10	406947	3586	Gene	Gene	induction|amod|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	IL-10 inhibits miR-155 induction by toll-like receptors .
25381386	0	miR-155	41,48	IL-10	0,5	miR-155	IL-10	406947	3586	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	IL-10 regulates Aicda expression through miR-155 .
26698246	0	miR-155	42,49	LMP1	27,31	miR-155	LMP1	406947	9260	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Epstein-Barr_virus-encoded LMP1 increases miR-155 expression , which promotes radioresistance of nasopharyngeal_carcinoma via suppressing UBQLN1 .
27009385	0	miR-155	33,40	Matrix_Gla_protein	0,18	miR-155	Matrix Gla protein	406947	4256	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	Matrix_Gla_protein repression by miR-155 promotes oncogenic signals in breast_cancer MCF-7 cells .
18753206	0	miR-155	27,34	NF-kappaB	46,55	miR-155	NF-kappaB	406947	4790	Gene	Gene	attenuates|amod|START_ENTITY END_ENTITY|nsubj|attenuates	Epstein-Barr_virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence .
19359473	0	miR-155	50,57	SHIP1	21,26	miR-155	SHIP1	387173(Tax:10090)	16331(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Inositol phosphatase SHIP1 is a primary target of miR-155 .
25175984	0	miR-155	21,28	SHIP1	0,5	miR-155	SHIP1	406947	3635	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	SHIP1 is targeted by miR-155 in acute_myeloid_leukemia .
26447227	0	miR-155	0,7	SHIP1	106,111	miR-155	SHIP1	406947	3635	Gene	Gene	Upregulation|amod|START_ENTITY Is|nsubj|Upregulation Is|xcomp|Sufficient Sufficient|dep|END_ENTITY	miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1 .
22771905	0	miR-155	21,28	SOCS1	78,83	miR-155	SOCS1	406947	8651	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Interferon-b-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF .
23449975	0	miR-155	0,7	TAK1-binding_protein_2	86,108	miR-155	TAK1-binding protein 2	387173(Tax:10090)	68652(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR-155 regulates immune modulatory properties of mesenchymal stem cells by targeting TAK1-binding_protein_2 .
25775145	0	miR-155	28,35	activation-induced_cytidine_deaminase	89,126	miR-155	activation-induced cytidine deaminase	406947	57379	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Downregulated expression of miR-155 , miR-17 , and miR-181b , and upregulated expression of activation-induced_cytidine_deaminase and interferon-a in PBMCs from patients with SLE .
21062812	6	miR-155	930,937	c-MYB	909,914	miR-424	SIAH1	494336	6477	Gene	Gene	targeted|advcl|START_ENTITY targeted|nsubjpass|END_ENTITY	We show that c-MYB is targeted by miR-155 and miR-424 , that the tumor suppressor SIAH1 is targeted by miR-424 , and that c-SKI is potentially regulated by miR-155 .
27063128	0	miR-155	14,21	miR-146a	23,31	miR-155	miR-146a	406947	406938	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Detection of miR-155 , miR-146a in PBNCs and tissues from patients with oral_lichen_planus -RSB- .
21740905	0	miR-15a	19,26	Cyclin_T2	0,9	miR-15a	Cyclin T2	387174(Tax:10090)	72949(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	Cyclin_T2 : a novel miR-15a target gene involved in early spermatogenesis .
22002311	0	miR-15a	14,21	Myc	0,3	miR-15a	Myc	406948	4609	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Myc represses miR-15a / miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell_lymphomas .
21816877	0	miR-15a	138,145	miR-16-1	146,154	miR-15a	miR-16-1	406948	406950	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A novel marsupial pri-miRNA transcript has a putative role in gamete maintenance and defines a vertebrate miRNA cluster paralogous to the miR-15a / miR-16-1 cluster .
22002311	0	miR-15a	14,21	miR-16-1	22,30	miR-15a	miR-16-1	406948	406950	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Myc represses miR-15a / miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell_lymphomas .
23649629	0	miR-15a	89,96	miR-16-1	97,105	miR-15a	miR-16-1	406948	406950	Gene	Gene	/|amod|START_ENTITY down-regulation|nmod|/ END_ENTITY|nsubj|down-regulation	Hepatitis_B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a / miR-16-1 in hepatocytes .
25092292	0	miR-15b	0,7	16-2	8,12	miR-15b	16-2	406949	3544	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	miR-15b / 16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung .
25783158	0	miR-15b	65,72	MTSS1	81,86	miR-15b	MTSS1	406949	9788	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	EGF induces microRNAs that target suppressors of cell migration : miR-15b targets MTSS1 in breast_cancer .
25721211	0	miR-15b	0,7	PEBP4	67,72	miR-15b	PEBP4	406949	157310	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-15b regulates cisplatin resistance and metastasis by targeting PEBP4 in human lung_adenocarcinoma cells .
26166038	0	miR-15b	0,7	SMURF2	65,71	miR-15b	SMURF2	406949	64750	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic_cancer .
26166038	0	miR-15b	0,7	SMURF2	65,71	miR-15b	SMURF2	406949	64750	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic_cancer .
25435430	0	miR-16	85,91	Bcl-2	15,20	miR-16	Bcl-2	51573	596	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	miR-16 targets Bcl-2 in paclitaxel-resistant lung_cancer cells and overexpression of miR-16 along with miR-17 causes unprecedented sensitivity by simultaneously modulating autophagy and apoptosis .
26061016	0	miR-16	79,85	Claudin-2	20,29	miR-16	Claudin-2	51573	9075	Gene	Gene	Up-Regulation|nmod|START_ENTITY END_ENTITY|nmod|Up-Regulation	Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung_Adenocarcinoma A549 Cells .
26655091	0	miR-16	0,6	fibroblast_growth_factor_2	15,41	miR-16	fibroblast growth factor 2	51573	2247	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-16 targets fibroblast_growth_factor_2 to inhibit NPC cell proliferation and invasion via PI3K/AKT and MAPK signaling pathways .
22002311	0	miR-16-1	22,30	Myc	0,3	miR-16-1	Myc	406950	4609	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Myc represses miR-15a / miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell_lymphomas .
21816877	0	miR-16-1	146,154	miR-15a	138,145	miR-16-1	miR-15a	406950	406948	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	A novel marsupial pri-miRNA transcript has a putative role in gamete maintenance and defines a vertebrate miRNA cluster paralogous to the miR-15a / miR-16-1 cluster .
22002311	0	miR-16-1	22,30	miR-15a	14,21	miR-16-1	miR-15a	406950	406948	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Myc represses miR-15a / miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell_lymphomas .
23649629	0	miR-16-1	97,105	miR-15a	89,96	miR-16-1	miR-15a	406950	406948	Gene	Gene	START_ENTITY|nsubj|down-regulation down-regulation|nmod|/ /|amod|END_ENTITY	Hepatitis_B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a / miR-16-1 in hepatocytes .
24486549	0	miR-17	13,19	FoxA1	35,40	miR-17	FoxA1	723905(Tax:10090)	15375(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The microRNA miR-17 regulates lung FoxA1 expression during lipopolysaccharide-induced acute_lung_injury .
25161318	0	miR-17	99,105	IL-7	36,40	miR-17	IL-7	406952	3574	Gene	Gene	START_ENTITY|nsubj|receptor receptor|compound|END_ENTITY	T_cell_receptor stimulation impairs IL-7 receptor signaling by inducing expression of the microRNA miR-17 to target Janus_kinase_1 .
20148420	0	miR-17-5p	22,31	CD4	35,38	miR-17-5p	CD4	406952	920	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Altered expression of miR-17-5p in CD4 + lymphocytes of relapsing-remitting multiple_sclerosis patients .
23583198	0	miR-17-5p	14,23	E2F-1	52,57	miR-17-5p	E2F-1	406952	1869	Gene	Gene	Repression|nmod|START_ENTITY Repression|nmod|END_ENTITY	Repression of miR-17-5p with elevated expression of E2F-1 and c-MYC in non-metastatic hepatocellular_carcinoma and enhancement of cell growth upon reversing this expression pattern .
27093644	0	miR-17-5p	43,52	H19	19,22	miR-17-5p	H19	406952	283120	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid_cancer .
20505989	0	miR-17-5p	0,9	HBP1	90,94	miR-17-5p	HBP1	406952	26959	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	miR-17-5p promotes human breast_cancer cell migration and invasion through suppression of HBP1 .
26622832	0	miR-17-5p	46,55	PTEN	8,12	miR-17-5p	PTEN	406952	5728	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Reduced PTEN expression and overexpression of miR-17-5p , -19 a-3p , -19 b-3p , -21 -5 p , -130 b-3p , -221 -3 p and -222 -3 p by glioblastoma stem-like cells following irradiation .
24801601	0	miR-17-5p	0,9	SOCS6	46,51	miR-17-5p	SOCS6	406952	9306	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-17-5p promotes proliferation by targeting SOCS6 in gastric_cancer cells .
25561420	0	miR-17-5p	0,9	YES1	23,27	miR-17-5p	YES1	406952	7525	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	miR-17-5p up-regulates YES1 to modulate the cell cycle progression and apoptosis in ovarian_cancer cell lines .
26013170	0	miR-181a	0,8	RGS16	17,22	miR-181a	RGS16	387176(Tax:10090)	6004	Gene	Gene	Targets|amod|START_ENTITY END_ENTITY|nsubj|Targets	miR-181a Targets RGS16 to Promote Chondrosarcoma_Growth , Angiogenesis , and Metastasis .
23241956	0	miR-181a	18,26	TGF-b	0,5	miR-181a	TGF-b	387176(Tax:10090)	7040	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TGF-b upregulates miR-181a expression to promote breast_cancer metastasis .
23256998	0	miR-181a	22,30	c-fos	48,53	miR-181a	c-fos	387176(Tax:10090)	2353	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Regulatory effect of miR-181a on expression of c-fos in cochlear hair cells -RSB- .
24971532	0	miR-182	0,7	CHL1	16,20	miR-182	CHL1	406958	10752	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-182 targets CHL1 and controls tumor growth and invasion in papillary_thyroid_carcinoma .
25684245	0	miR-182	12,19	CLOCK	41,46	miR-182	CLOCK	100314172(Tax:10116)	60447(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of miR-182 in regulating pineal CLOCK expression after hypoxia-ischemia brain injury in neonatal rats .
22917588	0	miR-182	0,7	FGF9	71,75	miR-182	FGF9	100314172(Tax:10116)	25444(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM , respectively at an early stage following sciatic nerve_injury .
26205124	0	miR-182	18,25	HIF1a	35,40	miR-182	HIF1a	387177(Tax:10090)	15251(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Hypoxia-inducible miR-182 enhances HIF1a signaling via targeting PHD2 and FIH1 in prostate cancer .
26205124	0	miR-182	18,25	HIF1a	35,40	miR-182	HIF1a	387177(Tax:10090)	15251(Tax:10090)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Hypoxia-inducible miR-182 enhances HIF1a signaling via targeting PHD2 and FIH1 in prostate cancer .
20935646	0	miR-182	13,20	IL-2	35,39	miR-182	IL-2	406958	3558	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes .
23153509	0	miR-182	39,46	NAMPT	19,24	miR-182	NAMPT	406958	10135	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of NAMPT expression by miR-182 is involved in Tat-induced HIV-1 long terminal repeat -LRB- LTR -RRB- transactivation .
23006329	0	miR-182	14,21	TGF-b	0,5	miR-182	TGF-b	406958	7040	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	TGF-b induces miR-182 to sustain NF-kB activation in glioma subsets .
24445397	0	miR-182	18,25	TGF-b	0,5	miR-182	TGF-b	406958	7040	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	TGF-b upregulates miR-182 expression to promote gallbladder_cancer metastasis by targeting CADM1 .
25738520	0	miR-182	0,7	forkhead_box_F2_transcription_factor	55,91	miR-182	forkhead box F2 transcription factor	406958	2295	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-182 promotes cell growth and invasion by targeting forkhead_box_F2_transcription_factor in colorectal_cancer .
25337200	0	miR-183	0,7	Ezrin	57,62	miR-183	Ezrin	406959	7430	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-183 inhibits invasion of gastric_cancer by targeting Ezrin .
25055867	0	miR-183	43,50	mTOR	51,55	miR-183	mTOR	387178(Tax:10090)	21977(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	SMN regulates axonal local translation via miR-183 / mTOR pathway .
26063221	0	miR-183	0,7	programmed_cell_death_4	86,109	miR-183	programmed cell death 4	406959	27250	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-183 regulates biological behavior in papillary_thyroid_carcinoma by targeting the programmed_cell_death_4 .
21934093	0	miR-184	28,35	TNFAIP2	52,59	miR-184	TNFAIP2	406960	7127	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous_cell_carcinoma_of_the_head_and_neck .
23934683	0	miR-185	72,79	GPX2	104,108	miR-185	GPX2	406961	2877	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Selenium alters miRNA profile in an intestinal cell line : evidence that miR-185 regulates expression of GPX2 and SEPSH2 .
21186079	0	miR-185	0,7	RhoA	16,20	miR-185	RhoA	406961	387	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells .
26036598	0	miR-185	114,121	somatostatin_receptor_subtype_2	14,45	miR-185	somatostatin receptor subtype 2	100314243(Tax:10116)	54305(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of somatostatin_receptor_subtype_2 in growth_hormone-secreting pituitary_adenoma and the regulation of miR-185 .
24935378	0	miR-186	0,7	Glut1	37,42	miR-186	Glut1	406962	6513	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR-186 regulates glycolysis through Glut1 during the formation of cancer-associated fibroblasts .
18682393	0	miR-186	10,17	P2X7_receptor	87,100	miR-186	P2X7 receptor	406962	5027	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7_receptor by activation of instability sites at the 3 ' - untranslated region of the gene that decrease steady-state levels of the transcript .
25867064	0	miR-186	0,7	Twist1	22,28	miR-186	Twist1	406962	7291	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	miR-186 regulation of Twist1 and ovarian_cancer sensitivity to cisplatin .
24955153	0	miR-18a	0,7	DICER1	22,28	miR-18a	DICER1	406953	23405	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	miR-18a downregulates DICER1 and promotes proliferation and metastasis of nasopharyngeal_carcinoma .
23396362	0	miR-190	52,59	PHLPP1	78,84	miR-190	PHLPP1	406965	23239	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	NF-kB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1 .
25784653	0	miR-191	0,7	C/EBPb	76,82	miR-191	C/EBPb	406966	1051	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-191 promotes tumorigenesis of human colorectal_cancer through targeting C/EBPb .
23724042	0	miR-191	40,47	MDM4	64,68	miR-191	MDM4	406966	4194	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal_squamous_cell_carcinoma .
22542158	0	miR-191	41,48	miR-26a-2	29,38	miR-191	miR-26a-2	406966	407016	Gene	Gene	*|nummod|START_ENTITY END_ENTITY|dep|*	Analysis of serum microRNAs -LRB- miR-26a-2 * , miR-191 , miR-337-3p and miR-378 -RRB- as potential biomarkers in renal_cell_carcinoma .
22121083	0	miR-1915	0,8	Bcl-2	18,23	miR-1915	Bcl-2	100302129	596	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|xcomp|END_ENTITY	miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal_carcinoma cells .
25955157	0	miR-1915	12,20	CD133	64,69	miR-1915	CD133	100302129	8842	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Correction : miR-1915 and miR-1225-5p Regulate the Expression of CD133 , PAX2 and TLR2 in Adult Renal Progenitor Cells .
25955157	0	miR-1915	12,20	CD133	64,69	miR-1915	CD133	100302129	8842	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|END_ENTITY	Correction : miR-1915 and miR-1225-5p Regulate the Expression of CD133 , PAX2 and TLR2 in Adult Renal Progenitor Cells .
20813867	0	miR-192	33,40	WNK1	14,18	miR-192	WNK1	406967	65125	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of WNK1 expression by miR-192 and aldosterone .
21670079	0	miR-193a	14,22	Max	37,40	miR-193a	Max	406968	4149	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of miR-193a expression by Max and RXRa activates K-Ras and PLAU to mediate distinct aspects of cellular transformation .
24496888	0	miR-193b	0,8	Smad3	50,55	miR-193b	Smad3	574455	4088	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-193b promotes cell proliferation by targeting Smad3 in human glioma .
24891187	0	miR-195	0,7	HDGF	16,20	miR-195	HDGF	406971	3068	Gene	Gene	Targets|amod|START_ENTITY END_ENTITY|nsubj|Targets	miR-195 Targets HDGF to inhibit proliferation and invasion of NSCLC cells .
25100012	0	miR-195	25,32	HMGA1	0,5	miR-195	HMGA1	387190(Tax:10090)	15361(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	HMGA1 is a new target of miR-195 involving isoprenaline-induced cardiomyocyte hypertrophy .
23804758	0	miR-195	0,7	HuR	22,25	miR-195	HuR	406971	1994	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	miR-195 competes with HuR to modulate stim1 mRNA stability and regulate cell migration .
24874051	0	miR-195	0,7	IGF1R	71,76	miR-195	IGF1R	406971	3480	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-195 inhibits the growth and metastasis of NSCLC cells by targeting IGF1R .
26527888	0	miR-195	0,7	Raf1	30,34	miR-195	Raf1	406971	5894	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	miR-195 is a key regulator of Raf1 in thyroid_cancer .
23139153	0	miR-197	0,7	p120_catenin	90,102	miR-197	p120 catenin	406974	1500	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	miR-197 induces epithelial-mesenchymal transition in pancreatic_cancer cells by targeting p120_catenin .
26553359	0	miR-198	0,7	SHMT1	16,21	miR-198	SHMT1	406975	6470	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung_adenocarcinoma .
25520864	0	miR-199a-3p	0,11	AXL	83,86	miR-199a-3p	AXL	406977	558	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-199a-3p negatively regulates the progression of osteosarcoma through targeting AXL .
21055388	0	miR-199a-3p	0,11	CD44	20,24	miR-199a-3p	CD44	406977	960	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular_carcinoma cell lines .
24972723	0	miR-199a-3p	23,34	NLK	0,3	miR-199a-3p	NLK	406977	51701	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	NLK , a novel target of miR-199a-3p , functions as a tumor suppressor in colorectal_cancer .
25389292	0	miR-199a2	71,80	Endothelin-1	92,104	miR-199a2	Endothelin-1	723821(Tax:10090)	13614(Tax:10090)	Gene	Gene	Expression|amod|START_ENTITY Expression|compound|END_ENTITY	Peroxisome Proliferator-activated Receptor-a-mediated Transcription of miR-199a2 Attenuates Endothelin-1 Expression via Hypoxia-inducible Factor-1a .
26873752	0	miR-19a	0,7	CTGF	32,36	miR-19a	CTGF	406979	1490	Gene	Gene	Expression|dep|START_ENTITY Expression|compound|END_ENTITY	miR-19a , -19 b , and -26 b Mediate CTGF Expression and Pulmonary Fibroblast Differentiation .
23621248	0	miR-19a	0,7	SOCS1	65,70	miR-19a	SOCS1	406979	8651	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-19a promotes cell growth and tumorigenesis through targeting SOCS1 in gastric_cancer .
21271217	0	miR-19a	27,34	TNF-a	0,5	miR-19a	TNF-a	406979	7124	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	TNF-a is a novel target of miR-19a .
25643913	0	miR-19b	0,7	hTERT	18,23	miR-19b	hTERT	406980	7015	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells .
21926171	0	miR-200a	0,8	Nrf2	19,23	miR-200a	Nrf2	406983	4780	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast_cancer cells .
21596753	0	miR-200a	0,8	SIRT1	19,24	miR-200a	SIRT1	406983	23411	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition -LRB- EMT -RRB- - like transformation in mammary epithelial cells .
26450995	0	miR-200b	49,57	CITED2	23,29	miR-200b	CITED2	406984	10370	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	High glucose-repressed CITED2 expression through miR-200b triggers the unfolded protein response and endoplasmic reticulum stress .
21081489	0	miR-200b	0,8	Ets-1	17,22	miR-200b	Ets-1	406984	2113	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells .
23558708	0	miR-200b	0,8	GATA-4	17,23	miR-200b	GATA-4	406984	2626	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-200b targets GATA-4 during cell growth and differentiation .
26012256	0	miR-200b	145,153	Notch-1	110,117	miR-200b	Notch-1	406984	4851	Gene	Gene	signaling|advcl|START_ENTITY END_ENTITY|acl|signaling	Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung_cancer cells by inactivating of Notch-1 signaling and switching on miR-200b .
24667864	0	miR-200b	68,76	TGF-b1	0,6	miR-200b	TGF-b1	406984	7040	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	TGF-b1 stimulates human Tenon 's capsule fibroblast proliferation by miR-200b and its targeting of p27/kip1 and RND3 .
23543665	0	miR-200b	49,57	miR-146b	17,25	miR-200b	miR-146b	100314050(Tax:10116)	100314121(Tax:10116)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of miR-146b and down-regulation of miR-200b contribute to the cytotoxic effect of histone deacetylase inhibitors on ras-transformed thyroid cells .
22982443	0	miR-200c	0,8	BMI-1	86,91	miR-200c	BMI-1	406985	648	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	miR-200c inhibits melanoma_progression and drug resistance through down-regulation of BMI-1 .
25367080	0	miR-200c	0,8	BMI-1	107,112	miR-200c	BMI-1	406985	648	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|nmod|down-regulation down-regulation|nmod|END_ENTITY	miR-200c Inhibits invasion , migration and proliferation of bladder_cancer cells through down-regulation of BMI-1 and E2F3 .
25505268	0	miR-200c	80,88	BMI1	53,57	miR-200c	BMI1	406985	648	Gene	Gene	cluster|amod|START_ENTITY modulation|nmod|cluster END_ENTITY|nmod|modulation	PLK1 inhibition downregulates polycomb group protein BMI1 via modulation of the miR-200c / 141 cluster .
27105531	0	miR-200c	2,10	BMI1	72,76	miR-200c	BMI1	406985	648	Gene	Gene	START_ENTITY|parataxis|regulates regulates|dobj|activity activity|nmod|END_ENTITY	A miR-200c / 141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells .
25903073	0	miR-200c	0,8	Bmi1	9,13	miR-200c	Bmi1	406985	648	Gene	Gene	Axis|amod|START_ENTITY Axis|compound|END_ENTITY	miR-200c / Bmi1 Axis and Epithelial-Mesenchymal Transition Contribute to Acquired Resistance to BRAF Inhibitor Treatment .
23065816	0	miR-200c	15,23	EFNA1	40,45	miR-200c	EFNA1	406985	1942	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	G-A variant in miR-200c binding site of EFNA1 alters susceptibility to gastric_cancer .
20620960	0	miR-200c	0,8	FAP-1	68,73	miR-200c	FAP-1	406985	5783	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1 .
24710933	0	miR-200c	0,8	HMGB1	65,70	miR-200c	HMGB1	406985	3146	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-200c inhibits metastasis of breast_cancer cells by targeting HMGB1 .
21873159	0	miR-200c	25,33	KRAS	10,14	miR-200c	KRAS	406985	3845	Gene	Gene	222|amod|START_ENTITY regulates|dobj|222 regulates|nsubj|END_ENTITY	Oncogenic KRAS regulates miR-200c and miR-221 / 222 in a 3D-specific manner in colorectal_cancer cells .
24368337	0	miR-200c	39,47	KRAS	19,23	miR-200c	KRAS	406985	3845	Gene	Gene	targeted|advcl|START_ENTITY targeted|nsubjpass|END_ENTITY	The proto-oncogene KRAS is targeted by miR-200c .
26392416	0	miR-200c	0,8	KRAS	59,63	miR-200c	KRAS	406985	3845	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	miR-200c inhibits breast_cancer proliferation by targeting KRAS .
24424572	0	miR-200c	8,16	miR-141	17,24	miR-200c	miR-141	406985	406933	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of miR-200c / miR-141 in the regulation of epithelial-mesenchymal transition and migration in head_and_neck_squamous_cell_carcinoma .
25815280	0	miR-200c	23,31	miR-141	14,21	miR-200c	miR-141	406985	406933	Gene	Gene	miR-30b|amod|START_ENTITY miR-30b|amod|END_ENTITY	Evaluation of miR-141 , miR-200c , miR-30b Expression and Clinicopathological Features of Bladder_Cancer .
25475727	0	miR-203	0,7	BMI1	100,104	miR-203	BMI1	406986	648	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1 .
24040137	0	miR-203	0,7	PKCa	84,88	miR-203	PKCa	406986	5578	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-203 inhibits cell proliferation and migration_of_lung_cancer cells by targeting PKCa .
26382657	0	miR-203	0,7	RAB22A	70,76	miR-203	RAB22A	406986	57403	Gene	Gene	Acts|amod|START_ENTITY Acts|nmod|END_ENTITY	miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A .
23447531	0	miR-203	119,126	SNAI2	80,85	miR-203	SNAI2	406986	6591	Gene	Gene	represses|xcomp|START_ENTITY represses|nsubj|END_ENTITY	Signaling between transforming_growth_factor_b -LRB- TGF-b -RRB- and transcription factor SNAI2 represses expression of microRNA miR-203 to promote epithelial-mesenchymal transition and tumor metastasis .
26990535	0	miR-203	0,7	SOCS1	29,34	miR-203	SOCS1	406986	8651	Gene	Gene	START_ENTITY|dep|regulate regulate|dobj|END_ENTITY	miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential_thrombocythemia .
25910964	0	miR-203	0,7	Yes-1	22,27	miR-203	Yes-1	406986	7525	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral_cancer cells .
22846677	0	miR-203	0,7	phospholipase_A2_activating_protein	74,109	miR-203	phospholipase A2 activating protein	387199(Tax:10090)	18786(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	miR-203 regulates nociceptive sensitization after incision by controlling phospholipase_A2_activating_protein expression .
23152059	0	miR-204	0,7	Bcl-2	16,21	miR-204	Bcl-2	406987	596	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-204 targets Bcl-2 expression and enhances responsiveness of gastric_cancer .
26722467	0	miR-204	0,7	FOXM1	77,82	miR-204	FOXM1	406987	2305	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-204 inhibits invasion and epithelial-mesenchymal transition by targeting FOXM1 in esophageal_cancer .
23516376	0	miR-204	62,69	Pax6	0,4	miR-204	Pax6	387200(Tax:10090)	18508(Tax:10090)	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Pax6 regulates gene expression in the vertebrate lens through miR-204 .
27020592	0	miR-204	108,115	ZEB1	116,120	miR-204	ZEB1	406987	6935	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204 / ZEB1 axis in nasopharyngeal_carcinoma .
26729198	0	miR-204	0,7	snai1	39,44	miR-204	snai1	406987	6615	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-204 regulates the EMT by targeting snai1 to suppress the invasion and migration of gastric_cancer .
23856247	0	miR-205	0,7	AKT	43,46	miR-205	AKT	406988	207	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|augment augment|dobj|signaling signaling|compound|END_ENTITY	miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small_cell_lung_cancer .
26446417	0	miR-205	0,7	AKT	64,67	miR-205	AKT	406988	207	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-205 promotes epithelial-mesenchymal transition by targeting AKT signaling in endometrial_cancer cells .
26515287	0	miR-205	0,7	CDK2AP1	96,103	miR-205	CDK2AP1	387201(Tax:10090)	13445(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	miR-205 promotes proliferation and invasion of laryngeal_squamous_cell_carcinoma by suppressing CDK2AP1 expression .
23589079	0	miR-205	0,7	ESRRG	68,73	miR-205	ESRRG	406988	2104	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-205 promotes tumor proliferation and invasion through targeting ESRRG in endometrial_carcinoma .
23856247	0	miR-205	0,7	PTEN	16,20	miR-205	PTEN	406988	5728	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small_cell_lung_cancer .
23571738	0	miR-205	0,7	androgen_receptor	33,50	miR-205	androgen receptor	406988	367	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	miR-205 negatively regulates the androgen_receptor and is associated with adverse outcome of prostate_cancer patients .
19341710	0	miR-206	44,51	Bone_morphogenetic_protein-2	0,28	miR-206	Bone morphogenetic protein-2	387202(Tax:10090)	12156(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 down-regulates miR-206 expression by blocking its maturation process .
20655308	0	miR-206	6,13	Hsp60	23,28	miR-206	Hsp60	406989	3329	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	miR-1 / miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes .
24603323	0	miR-206	0,7	LXRa	17,21	miR-206	LXRa	406989	10062	Gene	Gene	controls|nsubj|START_ENTITY controls|dobj|expression expression|compound|END_ENTITY	miR-206 controls LXRa expression and promotes LXR-mediated cholesterol efflux in macrophages .
25955685	0	miR-206	0,7	MRTF-A	57,63	miR-206	MRTF-A	406989	57591	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	miR-206 inhibits metastasis-relevant traits by degrading MRTF-A in anaplastic_thyroid_cancer .
19721712	0	miR-206	31,38	Nuclear_receptor_SHP	0,20	miR-206	Nuclear receptor SHP	406989	8431	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Nuclear_receptor_SHP activates miR-206 expression via a cascade dual inhibitory mechanism .
21324893	0	miR-206	19,26	TGF-beta	0,8	miR-206	TGF-beta	387202(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	TGF-beta regulates miR-206 and miR-29 to control myogenic differentiation through regulation of HDAC4 .
22926857	0	miR-206	0,7	brain-derived_neurotrophic_factor	18,51	miR-206	brain-derived neurotrophic factor	387202(Tax:10090)	12064(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	miR-206 regulates brain-derived_neurotrophic_factor in Alzheimer_disease model .
19245789	0	miR-206	32,39	miR-1	26,31	miR-206	miR-1	100314052(Tax:10116)	100314077(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Upregulated expression of miR-1 / miR-206 in a rat model of myocardial_infarction .
20655308	0	miR-206	6,13	miR-1	0,5	miR-206	miR-1	406989	79187	Gene	Gene	expression|amod|START_ENTITY contributing|nsubj|expression END_ENTITY|appos|contributing	miR-1 / miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes .
24464651	0	miR-20a	0,7	ABL2	74,78	miR-20a	ABL2	406982	27	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-20a promotes prostate_cancer invasion and migration through targeting ABL2 .
20458444	0	miR-20a	0,7	APP	57,60	miR-20a	APP	406982	351	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-20a promotes proliferation and invasion by targeting APP in human ovarian_cancer cells .
21242194	0	miR-20a	0,7	BNIP2	16,21	miR-20a	BNIP2	406982	663	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal_adenocarcinoma SW480 and SW620 cell lines .
22449978	0	miR-20a	0,7	TNKS2	54,59	miR-20a	TNKS2	406982	80351	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	miR-20a promotes migration and invasion by regulating TNKS2 in human cervical_cancer cells .
22682761	0	miR-20a	51,58	argonaute-2	23,34	miR-20a	argonaute-2	406982	27161	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The structure of human argonaute-2 in complex with miR-20a .
20232316	0	miR-20b	0,7	VEGF	18,22	miR-20b	VEGF	574032	7422	Gene	Gene	modulates|amod|START_ENTITY END_ENTITY|nsubj|modulates	miR-20b modulates VEGF expression by targeting HIF-1_alpha and STAT3 in MCF-7 breast_cancer cells .
23945289	0	miR-20b	78,85	early_growth_response-1	17,40	miR-20b	early growth response-1	574032	1958	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Crucial role for early_growth_response-1 in the transcriptional regulation of miR-20b in breast_cancer .
24699315	0	miR-21	0,6	15-PGDH	15,22	miR-21	15-PGDH	406991	3248	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth .
26460584	0	miR-21	0,6	BMP9	23,27	miR-21	BMP9	387140(Tax:10090)	12165(Tax:10090)	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	miR-21 synergizes with BMP9 in osteogenic differentiation by activating the BMP9/Smad signaling pathway in murine multilineage cells .
19578724	0	miR-21	29,35	BMPRII	0,6	miR-21	BMPRII	406991	659	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	BMPRII is a direct target of miR-21 .
24385703	0	miR-21	31,37	CA153	69,74	miR-21	CA153	406991	4582	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of serum miR-21 in breast_cancer compared with CA153 and CEA .
23533633	0	miR-21	39,45	CD24	0,4	miR-21	CD24	406991	100133941	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	CD24 induces expression of the oncomir miR-21 via Src , and CD24 and Src are both post-transcriptionally downregulated by the tumor suppressor miR-34a .
25658602	0	miR-21	51,57	CD24	12,16	miR-21	CD24	406991	100133941	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	Correction : CD24 Induces Expression of the Oncomir miR-21 via Src , and CD24 and Src Are Both Post-Transcriptionally Downregulated by the Tumor Suppressor miR-34a .
25769721	0	miR-21	0,6	CD24	97,101	miR-21	CD24	387140(Tax:10090)	12484(Tax:10090)	Gene	Gene	Liver_Fibrosis|amod|START_ENTITY Liver_Fibrosis|nmod|Cells Cells|compound|END_ENTITY	miR-21 Inhibition Reduces Liver_Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24 + Progenitor Cells .
25769721	0	miR-21	0,6	CD24	97,101	miR-21	CD24	387140(Tax:10090)	12484(Tax:10090)	Gene	Gene	Liver_Fibrosis|amod|START_ENTITY Liver_Fibrosis|nmod|Cells Cells|compound|END_ENTITY	miR-21 Inhibition Reduces Liver_Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24 + Progenitor Cells .
24098447	0	miR-21	13,19	CD4	23,26	miR-21	CD4	406991	920	Gene	Gene	START_ENTITY|nmod|+ +|compound|END_ENTITY	Dual role of miR-21 in CD4 + T-cells : activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells .
24098447	0	miR-21	56,62	CD4	23,26	miR-21	CD4	406991	920	Gene	Gene	T-cells|amod|START_ENTITY T-cells|amod|miR-21 miR-21|nmod|+ +|compound|END_ENTITY	Dual role of miR-21 in CD4 + T-cells : activation-induced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells .
25827073	0	miR-21	76,82	CDK5	83,87	miR-21	CDK5	406991	1020	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21 / CDK5 axis .
26873848	0	miR-21	23,29	CXCL10	119,125	miR-21	CXCL10	406991	3627	Gene	Gene	Expression|amod|START_ENTITY Expression|dep|Role Role|nmod|END_ENTITY	Estrogen Downregulates miR-21 Expression and Induces Inflammatory Infiltration of Macrophages in Polymyositis : Role of CXCL10 .
24895913	0	miR-21	0,6	DDAH1	7,12	miR-21	DDAH1	406991	23576	Gene	Gene	START_ENTITY|appos|regulates regulates|nsubj|END_ENTITY	miR-21 / DDAH1 pathway regulates pulmonary vascular responses to hypoxia .
24012640	0	miR-21	14,20	EGFR	21,25	miR-21	EGFR	406991	1956	Gene	Gene	loop|amod|START_ENTITY loop|compound|END_ENTITY	Blockage of a miR-21 / EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas .
22907769	0	miR-21	0,6	FasL	17,21	miR-21	FasL	406991	356	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	miR-21 represses FasL in microglia and protects against microglia-mediated neuronal cell death following hypoxia/ischemia .
23177026	0	miR-21	105,111	FasL	160,164	miR-21	FasL	406991	356	Gene	Gene	expression|amod|START_ENTITY confers|nsubj|expression confers|xcomp|chemoresistance chemoresistance|advcl|targeting targeting|dobj|END_ENTITY	The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic_cancer , and miR-21 expression confers chemoresistance by targeting FasL .
19278956	0	miR-21	15,21	Gfi1	0,4	miR-21	Gfi1	406991	2672	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Gfi1 regulates miR-21 and miR-196b to control myelopoiesis .
25605429	0	miR-21	0,6	HMGCR	107,112	miR-21	HMGCR	406991	3156	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic_fatty_liver_disease by targeting HMGCR .
26101800	0	miR-21	27,33	IL-6	4,8	miR-21	IL-6	406991	3569	Gene	Gene	pathway|nmod|START_ENTITY involved|nsubjpass|pathway END_ENTITY|parataxis|involved	The IL-6 / STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes .
26252635	0	miR-21	50,56	IL-6	0,4	miR-21	IL-6	406991	3569	Gene	Gene	Inhibits|nmod|START_ENTITY Inhibits|nsubj|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
26252635	0	miR-21	50,56	IL-6	0,4	miR-21	IL-6	406991	3569	Gene	Gene	Inhibits|nmod|START_ENTITY Inhibits|nsubj|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
23443810	0	miR-21	10,16	MMP-9	49,54	miR-21	MMP-9	387140(Tax:10090)	17395(Tax:10090)	Gene	Gene	START_ENTITY|advcl|regulating regulating|dobj|END_ENTITY	Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic_nephropathy mice .
26660281	0	miR-21	13,19	MicroRNA-21	0,11	miR-21	MicroRNA-21	406991	406991	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- expression in hypothermic machine perfusate may be predictive of early outcomes in kidney transplantation .
26806747	0	miR-21	48,54	MyD88	21,26	miR-21	MyD88	406991	4615	Gene	Gene	signaling|advcl|START_ENTITY END_ENTITY|acl|signaling	-LSB- Modulation of TLR-4 / MyD88 signaling cascade by miR-21 is involved in airway immunologic_dysfunction induced by cold air exposure -RSB- .
17991735	0	miR-21	82,88	PDCD4	25,30	miR-21	PDCD4	406991	27250	Gene	Gene	target|nmod|START_ENTITY target|nsubj|Programmed_cell_death_4 Programmed_cell_death_4|appos|END_ENTITY	Programmed_cell_death_4 -LRB- PDCD4 -RRB- is an important functional target of the microRNA miR-21 in breast_cancer cells .
19473551	0	miR-21	14,20	PDCD4	44,49	miR-21	PDCD4	406991	27250	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|PTEN PTEN|dep|END_ENTITY	Expression of miR-21 and its targets -LRB- PTEN , PDCD4 , TM1 -RRB- in flat_epithelial_atypia_of_the_breast in relation to ductal_carcinoma_in_situ and invasive_carcinoma .
20219857	0	miR-21	36,42	PDCD4	133,138	miR-21	PDCD4	100314000(Tax:10116)	64031(Tax:10116)	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4 .
21279518	0	miR-21	45,51	PDCD4	0,5	miR-21	PDCD4	406991	27250	Gene	Gene	levels|amod|START_ENTITY correlates|nmod|levels correlates|nsubj|loss loss|nummod|END_ENTITY	PDCD4 nuclear loss inversely correlates with miR-21 levels in colon_carcinogenesis .
21602271	0	miR-21	101,107	PDCD4	166,171	miR-21	PDCD4	406991	27250	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Identification of novel microRNA signatures linked to human lupus_disease activity and pathogenesis : miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression .
22212233	0	miR-21	43,49	PDCD4	0,5	miR-21	PDCD4	406991	27250	Gene	Gene	levels|amod|START_ENTITY correlated|nmod|levels correlated|nsubj|expression expression|compound|END_ENTITY	PDCD4 expression inversely correlated with miR-21 levels in gastric_cancers .
22353043	0	miR-21	118,124	PDCD4	125,130	miR-21	PDCD4	406991	27250	Gene	Gene	TGF-b1|dep|START_ENTITY U251|nmod|TGF-b1 apoptosis|dobj|U251 apoptosis|nsubj|pathway pathway|nummod|END_ENTITY	Ursolic_acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-b1 / miR-21 / PDCD4 pathway .
23824073	0	miR-21	63,69	PDCD4	70,75	miR-21	PDCD4	406991	27250	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Berberine sensitizes ovarian_cancer cells to cisplatin through miR-21 / PDCD4 axis .
23888942	0	miR-21	82,88	PDCD4	29,34	miR-21	PDCD4	406991	27250	Gene	Gene	gastric_cancer|nmod|START_ENTITY patients|nmod|gastric_cancer expression|nmod|patients expression|nummod|END_ENTITY	Oxidative stress upregulates PDCD4 expression in patients with gastric_cancer via miR-21 .
24902663	0	miR-21	13,19	PDCD4	75,80	MiR-21	PDCD4	406991	27250	Gene	Gene	downregulates|dep|START_ENTITY tumor|nsubj|downregulates tumor|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation , proliferation , and metastasis in renal_cell_carcinoma .
26212010	0	miR-21	80,86	PDCD4	99,104	miR-21	PDCD4	406991	27250	Gene	Gene	downregulation|amod|START_ENTITY downregulation|dep|END_ENTITY	Stat3 regulates ErbB-2 expression and co-opts ErbB-2 nuclear function to induce miR-21 expression , PDCD4 downregulation and breast_cancer metastasis .
26252635	0	miR-21	50,56	PDCD4	41,46	miR-21	PDCD4	406991	27250	Gene	Gene	Inhibits|nmod|START_ENTITY Inhibits|dobj|Modulation Modulation|nmod|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
26252635	0	miR-21	50,56	PDCD4	41,46	miR-21	PDCD4	406991	27250	Gene	Gene	Inhibits|nmod|START_ENTITY Inhibits|dobj|Modulation Modulation|nmod|END_ENTITY	IL-6 Inhibits the Targeted Modulation of PDCD4 by miR-21 in Prostate_Cancer .
26595526	0	miR-21	76,82	PDCD4	60,65	miR-21	PDCD4	406991	27250	Gene	Gene	dependent|amod|START_ENTITY mechanism|amod|dependent regulates|nmod|mechanism regulates|dobj|END_ENTITY	ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism .
19473551	0	miR-21	14,20	PTEN	38,42	miR-21	PTEN	406991	5728	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of miR-21 and its targets -LRB- PTEN , PDCD4 , TM1 -RRB- in flat_epithelial_atypia_of_the_breast in relation to ductal_carcinoma_in_situ and invasive_carcinoma .
20223231	0	miR-21	13,19	PTEN	48,52	miR-21	PTEN	406991	5728	Gene	Gene	MicroRNA-21|dep|START_ENTITY represses|nsubj|MicroRNA-21 represses|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- represses tumor suppressor PTEN and promotes growth and invasion in non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
20797623	0	miR-21	20,26	PTEN	46,50	miR-21	PTEN	406991	5728	Gene	Gene	activation|acl|START_ENTITY activation|nmod|END_ENTITY	STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer .
21187093	0	miR-21	15,21	PTEN	66,70	miR-21	PTEN	406991	5728	Gene	Gene	START_ENTITY|nmod|resistance resistance|acl|daunorubicin daunorubicin|advcl|regulating regulating|dobj|expression expression|compound|END_ENTITY	Involvement of miR-21 in resistance to daunorubicin by regulating PTEN expression in the leukaemia K562 cell line .
22162762	0	miR-21	15,21	PTEN	0,4	miR-21	PTEN	406991	5728	Gene	Gene	processing|amod|START_ENTITY modulates|dobj|processing modulates|nsubj|END_ENTITY	PTEN modulates miR-21 processing via RNA-regulatory protein RNH1 .
22761812	0	miR-21	14,20	PTEN	140,144	miR-21	PTEN	406991	5728	Gene	Gene	Antagonism|nmod|START_ENTITY reverses|nsubj|Antagonism reverses|advcl|targeting targeting|dobj|END_ENTITY	Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN .
22956424	0	miR-21	13,19	PTEN	140,144	miR-21	PTEN	406991	5728	Gene	Gene	MicroRNA-21|dep|START_ENTITY expression|amod|MicroRNA-21 promotes|nsubj|expression promotes|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- expression promotes growth , metastasis , and chemo - or radioresistance in non-small_cell_lung_cancer cells by targeting PTEN .
23466500	0	miR-21	0,6	PTEN	74,78	miR-21	PTEN	406991	5728	Gene	Gene	confers|nsubj|START_ENTITY confers|advcl|regulating regulating|dobj|END_ENTITY	miR-21 confers cisplatin resistance in gastric_cancer cells by regulating PTEN .
23894315	0	miR-21	95,101	PTEN	38,42	miR-21	PTEN	406991	5728	Gene	Gene	restores|nmod|START_ENTITY restores|dobj|expression expression|compound|END_ENTITY	Difluorinated-curcumin _ -LRB- CDF -RRB- restores PTEN expression in colon_cancer cells by down-regulating miR-21 .
24221338	0	miR-21	61,67	PTEN	19,23	miR-21	PTEN	406991	5728	Gene	Gene	contributes|amod|START_ENTITY modulated|nmod|contributes modulated|nsubj|Down-regulation Down-regulation|nmod|expression expression|compound|END_ENTITY	Down-regulation of PTEN expression modulated by dysregulated miR-21 contributes to the progression of esophageal_cancer .
25084400	0	miR-21	13,19	PTEN	103,107	miR-21	PTEN	406991	5728	Gene	Gene	MicroRNA-21|dep|START_ENTITY regulates|nsubj|MicroRNA-21 regulates|advcl|targeting targeting|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- regulates cellular proliferation , invasion , migration , and apoptosis by targeting PTEN , RECK and Bcl-2 in lung squamous_carcinoma , Gejiu City , China .
25365510	0	miR-21	14,20	PTEN	118,122	miR-21	PTEN	406991	5728	Gene	Gene	Proliferation|amod|START_ENTITY Activation|nmod|Proliferation Apoptosis|nsubj|Activation Apoptosis|nmod|Gene Gene|compound|END_ENTITY	Activation of miR-21 by STAT3 Induces Proliferation and Suppresses Apoptosis in Nasopharyngeal_Carcinoma by Targeting PTEN Gene .
25451263	0	miR-21	10,16	PTEN	104,108	miR-21	PTEN	406991	5728	Gene	Gene	sensitizes|amod|START_ENTITY Targeting|dobj|sensitizes Sup-b15|dep|Targeting Sup-b15|nmod|upregulation upregulation|nmod|END_ENTITY	Targeting miR-21 sensitizes Ph + ALL Sup-b15 cells to imatinib-induced apoptosis through upregulation of PTEN .
25963606	0	miR-21	18,24	PTEN	113,117	miR-21	PTEN	406991	5728	Gene	Gene	Overexpression|nmod|START_ENTITY promotes|nsubj|Overexpression promotes|dobj|proliferation proliferation|nmod|cells cells|nmod|inhibition inhibition|nmod|END_ENTITY	Overexpression of miR-21 promotes the proliferation and migration of cervical_cancer cells via the inhibition of PTEN .
26415649	0	miR-21	0,6	PTEN	68,72	miR-21	PTEN	406991	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-21 promotes renal_fibrosis in diabetic_nephropathy by targeting PTEN and SMAD7 .
26787105	0	miR-21	121,127	PTEN	25,29	miR-21	PTEN	406991	5728	Gene	Gene	effect|dep|START_ENTITY effect|nmod|status status|compound|END_ENTITY	The prognostic effect of PTEN expression status in colorectal_cancer development and evaluation of factors affecting it : miR-21 and promoter methylation .
17968323	0	miR-21	13,19	Pdcd4	75,80	miR-21	Pdcd4	406991	27250	Gene	Gene	downregulates|dep|START_ENTITY tumor|nsubj|downregulates tumor|dobj|END_ENTITY	MicroRNA-21 -LRB- miR-21 -RRB- post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion , intravasation and metastasis in colorectal_cancer .
23469214	0	miR-21	24,30	Pdcd4	45,50	miR-21	Pdcd4	406991	27250	Gene	Gene	regulations|nmod|START_ENTITY regulations|nmod|END_ENTITY	Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation .
23578931	0	miR-21	0,6	Pdcd4	17,22	miR-21	Pdcd4	406991	27250	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	miR-21 represses Pdcd4 during cardiac valvulogenesis .
25979949	0	miR-21	65,71	Pdcd4	98,103	miR-21	Pdcd4	387140(Tax:10090)	18569(Tax:10090)	Gene	Gene	mediated|amod|START_ENTITY repression|amod|mediated repression|compound|END_ENTITY	Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression .
25979949	0	miR-21	65,71	Pdcd4	98,103	miR-21	Pdcd4	387140(Tax:10090)	18569(Tax:10090)	Gene	Gene	mediated|amod|START_ENTITY repression|amod|mediated repression|compound|END_ENTITY	Dicer1 imparts essential survival cues in Notch driven T-ALL via miR-21 mediated tumor suppressor Pdcd4 repression .
23441172	0	miR-21	0,6	Programmed_Cell_Death_4	106,129	miR-21	Programmed Cell Death 4	406991	27250	Gene	Gene	promotes|dep|START_ENTITY promotes|nsubj|transition transition|nmod|cells cells|acl|involving involving|dobj|END_ENTITY	miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed_Cell_Death_4 and Sprouty-1 .
17991735	0	miR-21	82,88	Programmed_cell_death_4	0,23	miR-21	Programmed cell death 4	406991	27250	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Programmed_cell_death_4 -LRB- PDCD4 -RRB- is an important functional target of the microRNA miR-21 in breast_cancer cells .
22162762	0	miR-21	15,21	RNH1	60,64	miR-21	RNH1	406991	6050	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	PTEN modulates miR-21 processing via RNA-regulatory protein RNH1 .
21872591	0	miR-21	0,6	RhoB	36,40	miR-21	RhoB	406991	388	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-21 targets the tumor suppressor RhoB and regulates proliferation , invasion and apoptosis in colorectal_cancer cells .
23936642	0	miR-21	68,74	TIMP-3	89,95	miR-21	TIMP-3	406991	7078	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Genetic heterogeneity of breast_cancer metastasis may be related to miR-21 regulation of TIMP-3 in translation .
25252191	0	miR-21	17,23	miR-141	25,32	miR-21	miR-141	406991	406933	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Investigation of miR-21 , miR-141 , and miR-221 expression levels in prostate_adenocarcinoma for associated risk of recurrence after radical prostatectomy .
25175929	0	miR-21	0,6	programmed_cell_death_4	21,44	miR-21	programmed cell death 4	406991	27250	Gene	Gene	increases|amod|START_ENTITY increases|dep|proliferation proliferation|amod|END_ENTITY	miR-21 increases the programmed_cell_death_4 gene-regulated cell proliferation in head and neck squamous_carcinoma cell lines .
25149066	0	miR-21-3p	0,9	L1CAM	37,42	miR-21-3p	L1CAM	406995	3897	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	miR-21-3p is a positive regulator of L1CAM in several human carcinomas .
23688833	0	miR-210	0,7	BNIP3	19,24	miR-210	BNIP3	406992	664	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	miR-210 suppresses BNIP3 to protect against the apoptosis of neural progenitor cells .
19652553	0	miR-210	9,16	MYC_antagonist_MNT	68,86	miR-210	MYC antagonist MNT	406992	4335	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	MicroRNA miR-210 modulates cellular response to hypoxia through the MYC_antagonist_MNT .
24962066	0	miR-210	39,46	PLC-beta_1	0,10	miR-210	PLC-beta 1	406992	23236	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	PLC-beta_1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells .
23024754	0	miR-210	50,57	ROD1	0,4	miR-210	ROD1	406992	9991	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	ROD1 is a seedless target gene of hypoxia-induced miR-210 .
26862518	0	miR-211	27,34	SOX2OT	58,64	miR-211	SOX2OT	406993	347689	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Down-Regulatory Effects of miR-211 on Long Non-Coding RNA SOX2OT and SOX2 Genes in Esophageal_Squamous_Cell_Carcinoma .
26277787	0	miR-211	0,7	SRCIN1	71,77	miR-211	SRCIN1	406993	80725	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-211 promotes non-small cell lung_cancer proliferation by targeting SRCIN1 .
23223004	0	miR-214	0,7	ATF4	16,20	miR-214	ATF4	406996	468	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-214 targets ATF4 to inhibit bone formation .
24802407	0	miR-214	0,7	LZTS1	100,105	miR-214	LZTS1	406996	11178	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|suppression suppression|nmod|END_ENTITY	miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1 .
21216304	0	miR-214	25,32	Plexin-B1	0,9	miR-214	Plexin-B1	406996	5364	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Plexin-B1 is a target of miR-214 in cervical_cancer and promotes the growth and invasion of HeLa cells .
25556274	0	miR-214	23,30	TFAM	121,125	miR-214	TFAM	406996	7019	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	The inhibitory role of miR-214 in cervical_cancer cells through directly targeting mitochondrial_transcription_factor_A -LRB- TFAM -RRB- .
23479198	0	miR-214	0,7	lactotransferrin	44,60	miR-214	lactotransferrin	387210(Tax:10090)	17002(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-214 promotes tumorigenesis by targeting lactotransferrin in nasopharyngeal_carcinoma .
26716895	0	miR-215	0,7	RUNX1	70,75	miR-215	RUNX1	406997	861	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-215 promotes malignant progression of gastric_cancer by targeting RUNX1 .
26676658	0	miR-215	0,7	X-chromosome-linked_inhibitor_of_apoptosis	95,137	miR-215	X-chromosome-linked inhibitor of apoptosis	406997	331	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	miR-215 functions as a tumor suppressor in epithelial_ovarian_cancer through regulation of the X-chromosome-linked_inhibitor_of_apoptosis .
20675343	0	miR-217	4,11	KRAS	112,116	miR-217	KRAS	387213(Tax:10090)	16653(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	The miR-217 microRNA functions as a potential tumor suppressor in pancreatic_ductal_adenocarcinoma by targeting KRAS .
21106538	0	miR-217	81,88	heme_oxygenase-1	14,30	miR-217	heme oxygenase-1	406999	3162	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 protein expression by miR-377 in combination with miR-217 .
24501422	0	miR-218	0,7	TGFb	50,54	miR-218	TGFb	387214(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	miR-218 regulates focal_adhesion_kinase-dependent TGFb signaling in fibroblasts .
24756834	0	miR-219	0,7	CD164	97,102	miR-219	CD164	407002	8763	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-219 inhibits the proliferation , migration and invasion of medulloblastoma cells by targeting CD164 .
25356169	0	miR-219	0,7	PRKCI	70,75	miR-219	PRKCI	407002	5584	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-219 inhibits the growth and metastasis of TSCC cells by targeting PRKCI .
26437241	0	miR-22	13,19	HDAC4	53,58	miR-22	HDAC4	387141(Tax:10090)	208727(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote TH17 cell-dependent emphysema .
20214878	0	miR-22	27,33	Max	44,47	miR-22	Max	407004	4149	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	Differentiation-associated miR-22 represses Max expression and inhibits cell cycle progression .
26662303	0	miR-22	0,6	SIRT1	108,113	miR-22	SIRT1	407004	23411	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-22 inhibits the proliferation , motility , and invasion of human glioblastoma cells by directly targeting SIRT1 .
26912776	0	miR-22	0,6	SIRT1	68,73	miR-22	SIRT1	387141(Tax:10090)	93759(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-22 inhibits mouse ovarian granulosa cell apoptosis by targeting SIRT1 .
26964730	0	miR-22	61,67	SIRT1	70,75	miR-22	SIRT1	407004	23411	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	PDE5 inhibition ameliorates visceral adiposity targeting the miR-22 / SIRT1 pathway : evidence from the CECSID trial .
24295494	0	miR-221	0,7	PTEN	96,100	miR-221	PTEN	723827(Tax:10090)	19211(Tax:10090)	Gene	Gene	222|amod|START_ENTITY confers|nsubj|222 confers|advcl|activating activating|xcomp|independent independent|nmod|status status|compound|END_ENTITY	miR-221 / 222 confers radioresistance in glioblastoma cells through activating Akt independent of PTEN status .
26397386	0	miR-221	0,7	PTEN	114,118	miR-221	PTEN	407006	5728	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|downregulation downregulation|nmod|END_ENTITY	miR-221 increases osteosarcoma cell proliferation , invasion and migration partly through the downregulation of PTEN .
26501139	0	miR-221	0,7	PTEN	69,73	miR-221	PTEN	407006	5728	Gene	Gene	Promotes|amod|START_ENTITY Epithelial-Mesenchymal|nsubj|Promotes Epithelial-Mesenchymal|nmod|END_ENTITY	miR-221 Promotes Epithelial-Mesenchymal Transition through Targeting PTEN and Forms a Positive Feedback Loop with b-catenin/c-Jun Signaling Pathway in Extra-Hepatic_Cholangiocarcinoma .
24601884	0	miR-222	115,122	ERa	141,144	miR-222	ERa	407007	2099	Gene	Gene	START_ENTITY|nmod|regulator regulator|nmod|END_ENTITY	Differential expression of microRNAs in omental adipose tissue from gestational_diabetes_mellitus subjects reveals miR-222 as a regulator of ERa expression in estrogen-induced insulin resistance .
21453483	0	miR-223	0,7	Artemin	54,61	miR-223	Artemin	407008	9048	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-223 regulates migration and invasion by targeting Artemin in human esophageal_carcinoma .
23857984	0	miR-223	66,73	FBXW7	29,34	miR-223	FBXW7	723814(Tax:10090)	50754(Tax:10090)	Gene	Gene	activating|xcomp|START_ENTITY targets|advcl|activating targets|dobj|suppressor suppressor|compound|END_ENTITY	The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T_cell_acute_lymphoblastic_leukemia .
24727676	0	miR-223	44,51	FBXW7	52,57	miR-223	FBXW7	407008	55294	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Notch and NF-kB signaling pathways regulate miR-223 / FBXW7 axis in T-cell_acute_lymphoblastic_leukemia .
25159729	0	miR-223	69,76	FBXW7	77,82	miR-223	FBXW7	407008	55294	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The sensitivity of gastric_cancer to trastuzumab is regulated by the miR-223 / FBXW7 pathway .
27021546	0	miR-223	11,18	IL-1b	36,41	miR-223	IL-1b	407008	3553	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of miR-223 on expression of IL-1b and IL-6 in human_gingival_fibroblasts .
24915805	0	miR-223	144,151	miR-150	135,142	miR-223	miR-150	100314060(Tax:10116)	100314158(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effects of 5,14-HEDGE , a 20-HETE mimetic , on lipopolysaccharide-induced changes in MyD88/TAK1/IKKb / IkB-a/NF-kB pathway and circulating miR-150 , miR-223 , and miR-297 levels in a rat model of septic_shock .
25341426	0	miR-224	13,20	E2F1	0,4	miR-224	E2F1	407009	1869	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	E2F1 induces miR-224 / 452 expression to drive EMT through TXNIP downregulation .
24992592	0	miR-23a	19,26	APAF1	27,32	miR-23a	APAF1	407010	317	Gene	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	The involvement of miR-23a / APAF1 regulation axis in colorectal_cancer .
25347474	0	miR-23a	10,17	CD8	21,24	miR-23a	CD8	407010	925	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|nummod|END_ENTITY	Targeting miR-23a in CD8 + cytotoxic T lymphocytes prevents tumor-dependent immunosuppression .
24440757	0	miR-23a	39,46	CTSC	69,73	miR-23a	CTSC	407010	1075	Gene	Gene	expression|amod|START_ENTITY expression|appos|expression expression|compound|END_ENTITY	All-trans_retinoic_acid -LRB- ATRA -RRB- induces miR-23a expression , decreases CTSC expression and granzyme_B activity leading to impaired NK cell cytotoxicity .
23929433	0	miR-23a	0,7	E-cadherin	17,27	miR-23a	E-cadherin	407010	999	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal_cancer .
21709246	0	miR-23a	0,7	X-linked_inhibitor_of_apoptosis	22,53	miR-23a	X-linked inhibitor of apoptosis	407010	331	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	miR-23a regulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- contributes to sex differences in the response to cerebral_ischemia .
21709246	0	miR-23a	0,7	XIAP	55,59	miR-23a	XIAP	407010	331	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	miR-23a regulation of X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- contributes to sex differences in the response to cerebral_ischemia .
23785404	0	miR-23a	0,7	interferon_regulatory_factor_1	16,46	miR-23a	interferon regulatory factor 1	407010	3659	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-23a targets interferon_regulatory_factor_1 and modulates cellular proliferation and paclitaxel-induced apoptosis in gastric_adenocarcinoma cells .
26553132	0	miR-23a	0,7	p53	17,20	miR-23a	p53	407010	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	miR-23a binds to p53 and enhances its association with miR-128 promoter .
26961602	0	miR-23b	0,7	Smad_3	16,22	miR-23b	Smad 3	387217(Tax:10090)	17127(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-23b targets Smad_3 and ameliorates the LPS-inhibited osteogenic differentiation in preosteoblast MC3T3-E1 cells .
24002170	0	miR-23b	30,37	TFAM	0,4	miR-23b	TFAM	407011	7019	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	TFAM is directly regulated by miR-23b in glioma .
25512615	0	miR-25	46,52	AURKA	21,26	miR-25	AURKA	407014	6790	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|compound|END_ENTITY	p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small_Cell_Neuroendocrine_Carcinoma .
25960208	0	miR-25	0,6	CDKN1C	55,61	miR-25	CDKN1C	407014	1028	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-25 promotes glioma cell proliferation by targeting CDKN1C .
23246404	0	miR-25	72,78	mitochondrial_calcium_uniporter	22,53	miR-25	mitochondrial calcium uniporter	407014	90550	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of the mitochondrial_calcium_uniporter by cancer-related miR-25 .
22094936	0	miR-26a	5,12	CDC2	21,25	miR-26a	CDC2	407015	983	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast_cancer .
23599767	0	miR-26a	0,7	EZH2	79,83	miR-26a	EZH2	387218(Tax:10090)	14056(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-26a inhibits invasion and metastasis of nasopharyngeal_cancer by targeting EZH2 .
23796420	0	miR-26a	0,7	HMGA1	75,80	miR-26a	HMGA1	407015	3159	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-26a inhibits proliferation and motility in bladder_cancer by targeting HMGA1 .
25361012	0	miR-26a	0,7	PTEN	52,56	miR-26a	PTEN	407015	5728	Gene	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic_lymphocytic_leukemia , but not PTEN mutation or promoter methylation .
18197755	0	miR-26a	90,97	SMAD1	115,120	miR-26a	SMAD1	407015	4086	Gene	Gene	START_ENTITY|nmod|factor factor|compound|END_ENTITY	Osteogenic differentiation of human adipose tissue-derived stem cells is modulated by the miR-26a targeting of the SMAD1 transcription factor .
26107166	0	miR-26a	18,25	TGR5	73,77	miR-26a	TGR5	387218(Tax:10090)	227289(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of miR-26a as a Target Gene of Bile_Acid Receptor GPBAR-1 / TGR5 .
21901171	0	miR-26a	80,87	c-Myc	17,22	miR-26a	c-Myc	407015	4609	Gene	Gene	Regulation|nmod|START_ENTITY Role|nmod|Regulation Role|nmod|END_ENTITY	Critical Role of c-Myc in Acute_Myeloid_Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2 .
22542158	0	miR-26a-2	29,38	miR-191	41,48	miR-26a-2	miR-191	407016	406966	Gene	Gene	START_ENTITY|dep|* *|nummod|END_ENTITY	Analysis of serum microRNAs -LRB- miR-26a-2 * , miR-191 , miR-337-3p and miR-378 -RRB- as potential biomarkers in renal_cell_carcinoma .
21901137	0	miR-26b	34,41	ATF2	26,30	miR-26b	ATF2	407017	1386	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Coordinated regulation of ATF2 by miR-26b in y-irradiated lung_cancer cells .
22737216	0	miR-26b	0,7	ATM	55,58	miR-26b	ATM	407017	472	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-26b promotes granulosa cell apoptosis by targeting ATM during follicular_atresia in porcine ovary .
26078955	0	miR-26b	27,34	Mcl-1	0,5	miR-26b	Mcl-1	407017	4170	Gene	Gene	Target|nmod|START_ENTITY Target|nsubj|END_ENTITY	Mcl-1 Is a Novel Target of miR-26b That Is Associated with the Apoptosis Induced by TRAIL in HCC Cells .
26920049	0	miR-26b	0,7	ULK2	40,44	miR-26b	ULK2	407017	9706	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-26b inhibits autophagy by targeting ULK2 in prostate_cancer cells .
25431021	0	miR-27	0,6	mitochondrial_fission_factor	66,94	miR-27	mitochondrial fission factor	407018	56947	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-27 regulates mitochondrial networks by directly targeting the mitochondrial_fission_factor .
19574223	0	miR-27a	34,41	FOXO1	25,30	miR-27a	FOXO1	407018	2308	Gene	Gene	Coordinate|advcl|START_ENTITY Coordinate|dobj|regulation regulation|nmod|END_ENTITY	Coordinate regulation of FOXO1 by miR-27a , miR-96 , and miR-182 in breast_cancer cells .
25399953	0	miR-27a	103,110	FOXO1	111,116	miR-27a	FOXO1	100314006(Tax:10116)	84482(Tax:10116)	Gene	Gene	Axis|amod|START_ENTITY Axis|compound|END_ENTITY	Chitosan Degradation Products Promote Nerve Regeneration by Stimulating Schwann Cell Proliferation via miR-27a / FOXO1 Axis .
25897249	0	miR-27a	24,31	FOXO1	67,72	miR-27a	FOXO1	407018	2308	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Adipose tissue-secreted miR-27a promotes liver_cancer by targeting FOXO1 in obese individuals .
24835395	0	miR-27a	0,7	IL-10	68,73	miR-27a	IL-10	407018	3586	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-27a regulates inflammatory response of macrophages by targeting IL-10 .
25128483	0	miR-27a	0,7	RKIP	67,71	miR-27a	RKIP	407018	5037	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-27a regulates cisplatin resistance and metastasis by targeting RKIP in human lung_adenocarcinoma cells .
26520906	0	miR-27b	0,7	LDLR	17,21	miR-27b	LDLR	387221(Tax:10090)	16835(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice .
19546220	0	miR-27b	137,144	ST14	99,103	miR-27b	ST14	407019	6768	Gene	Gene	regulation|amod|START_ENTITY independent|nmod|regulation independent|nsubj|effect effect|nmod|END_ENTITY	ST14 -LRB- suppression_of_tumorigenicity_14 -RRB- gene is a target for miR-27b , and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation .
19546220	0	miR-27b	61,68	ST14	0,4	miR-27b	ST14	407019	6768	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	ST14 -LRB- suppression_of_tumorigenicity_14 -RRB- gene is a target for miR-27b , and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation .
25807426	0	miR-28	0,6	aldehyde_dehydrogenase_2	60,84	miR-28	aldehyde dehydrogenase 2	723830(Tax:10090)	11669(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-28 promotes cardiac_ischemia by targeting mitochondrial aldehyde_dehydrogenase_2 -LRB- ALDH2 -RRB- in mus_musculus cardiac myocytes .
24527800	0	miR-296	0,7	Scribble	8,16	miR-296	Scribble	407022	23513	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	miR-296 / Scribble axis is deregulated in human breast_cancer and miR-296 restoration reduces tumour growth in vivo .
25435940	0	miR-29a	0,7	Hes1	18,22	miR-29a	Hes1	407021	3280	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	miR-29a activates Hes1 by targeting Nfia in esophageal_carcinoma cell line TE-1 .
25674218	0	miR-29a	0,7	Mcl-1	90,95	miR-29a	Mcl-1	407021	4170	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	miR-29a promotes intestinal epithelial apoptosis in ulcerative_colitis by down-regulating Mcl-1 .
26056009	0	miR-29a	0,7	QKI	62,65	miR-29a	QKI	407021	9444	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-29a promotes scavenger_receptor_A expression by targeting QKI -LRB- quaking -RRB- during monocyte-macrophage differentiation .
23315993	0	miR-29a	34,41	Syntaxin-1a	0,11	miR-29a	Syntaxin-1a	407021	6804	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Syntaxin-1a is a direct target of miR-29a in insulin-producing b-cells .
26056009	0	miR-29a	0,7	scavenger_receptor_A	17,37	miR-29a	scavenger receptor A	407021	4481	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	miR-29a promotes scavenger_receptor_A expression by targeting QKI -LRB- quaking -RRB- during monocyte-macrophage differentiation .
19509302	0	miR-29b	18,25	Dnmt3a	43,49	miR-29b	Dnmt3a	407024	13435(Tax:10090)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Potential role of miR-29b in modulation of Dnmt3a and Dnmt3b expression in primordial germ cells of female mouse embryos .
27022108	0	miR-29b	25,32	HDAC4	33,38	miR-29b	HDAC4	407024	9759	Gene	Gene	loop|amod|START_ENTITY loop|compound|END_ENTITY	Therapeutic targeting of miR-29b / HDAC4 epigenetic loop in multiple_myeloma .
27089893	0	miR-29b	85,92	LRP6	49,53	miR-29b	LRP6	407024	4040	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Posttranscriptional Regulation of Wnt-coreceptor LRP6 and RNA-binding Protein HuR by miR-29b in Intestinal Epithelial Cells .
25866219	0	miR-29b	0,7	MMP-2	84,89	miR-29b	MMP-2	407024	4313	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-29b inhibits the progression of esophageal_squamous_cell_carcinoma by targeting MMP-2 .
24992675	0	miR-29b	49,56	Mcl-1	17,22	miR-29b	Mcl-1	407024	4170	Gene	Gene	downregulation|nmod|START_ENTITY END_ENTITY|nmod|downregulation	BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian_cancer .
24091729	0	miR-29b	0,7	SOCS-1	16,22	miR-29b	SOCS-1	407024	8651	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple_myeloma and endothelial cells .
26175849	0	miR-29b	28,35	Stat3	86,91	miR-29b	Stat3	407024	6774	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Special suppressive role of miR-29b in HER2-positive breast cancer cells by targeting Stat3 .
26776158	0	miR-29b	58,65	TET1	95,99	miR-29b	TET1	407024	80312	Gene	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Enhanced MAPK signaling drives ETS1-mediated induction of miR-29b leading to downregulation of TET1 and changes in epigenetic modifications in a subset of lung SCC .
26212654	0	miR-29c	0,7	NAV3	18,22	miR-29c	NAV3	387224(Tax:10090)	260315(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer * _ s_disease .
21763284	0	miR-29c	0,7	TNFAIP3	16,23	miR-29c	TNFAIP3	407026	7128	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-29c targets TNFAIP3 , inhibits cell proliferation and induces apoptosis in hepatitis_B virus-related hepatocellular_carcinoma .
26862847	0	miR-29c	66,73	microRNA-29c	52,64	miR-29c	microRNA-29c	407026	407026	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Clinical response to azacitidine therapy depends on microRNA-29c -LRB- miR-29c -RRB- expression in older acute myeloid leukemia -LRB- AML -RRB- patients .
23338485	0	miR-301a	14,22	RUNX3	77,82	miR-301a	RUNX3	723834(Tax:10090)	12399(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric_cancer .
26464662	0	miR-301a	0,8	TIMP2	59,64	miR-301a	TIMP2	407027	7077	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-301a promotes cell proliferation by directly targeting TIMP2 in multiple myeloma .
26199092	0	miR-302c	66,74	IL8	75,78	miR-302c	IL8	442895	3576	Gene	Gene	Loop|amod|START_ENTITY Loop|compound|END_ENTITY	Loss of RACK1 Promotes Metastasis of Gastric_Cancer by Inducing a miR-302c / IL8 Signaling Loop .
23336071	0	miR-308	9,16	dMyc	27,31	miR-308	dMyc	12798452	31310(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila .
26912082	0	miR-30a	0,7	CAGE	36,40	miR-30a	CAGE	407029	168400	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|Expression Expression|nmod|END_ENTITY	miR-30a Regulates the Expression of CAGE and p53 and Regulates the Response to Anti-Cancer Drugs .
24858600	0	miR-30a	59,66	MD-2	16,20	miR-30a	MD-2	407029	23643	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a .
24447545	0	miR-30a	40,47	RUNX3	0,5	miR-30a	RUNX3	407029	864	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric_cancer cells .
26596830	0	miR-30a	22,29	Runx2	89,94	miR-30a	Runx2	407029	860	Gene	Gene	overexpression|nmod|START_ENTITY affects|nsubj|overexpression affects|dobj|proliferation proliferation|nmod|chondrosarcoma chondrosarcoma|nmod|END_ENTITY	The overexpression of miR-30a affects cell proliferation of chondrosarcoma via targeting Runx2 .
24858600	0	miR-30a	59,66	STAT1	0,5	miR-30a	STAT1	407029	6772	Gene	Gene	Expression|nmod|START_ENTITY Expression|compound|END_ENTITY	STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a .
24447545	0	miR-30a	40,47	vimentin	16,24	miR-30a	vimentin	407029	7431	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric_cancer cells .
25301066	0	miR-30b	15,22	Cyclophilin_D	34,47	miR-30b	Cyclophilin D	387226(Tax:10090)	105675(Tax:10090)	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	E2F1-regulated miR-30b suppresses Cyclophilin_D and protects heart from ischemia/reperfusion injury and necrotic cell death .
26998113	0	miR-30c	68,75	BCL9	0,4	miR-30c	BCL9	407031	607	Gene	Gene	targeted|advcl|START_ENTITY targeted|nsubjpass|END_ENTITY	BCL9 , a coactivator for Wnt/b-catenin transcription , is targeted by miR-30c and is associated with prostate_cancer progression .
25781190	0	miR-30c	0,7	Cdc42	33,38	miR-30c	Cdc42	407031	64465(Tax:10116)	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	miR-30c mediates upregulation of Cdc42 and Pak1 in diabetic_cardiomyopathy .
22701724	0	miR-30c	67,74	KRAS	89,93	miR-30c	KRAS	407031	3845	Gene	Gene	START_ENTITY|advcl|regulating regulating|dobj|END_ENTITY	Deregulated miRNAs in hereditary_breast_cancer revealed a role for miR-30c in regulating KRAS oncogene .
26101708	0	miR-30c	0,7	immediate_early_response_protein_2	73,107	miR-30c	immediate early response protein 2	407031	9592	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-30c negatively regulates the migration and invasion by targeting the immediate_early_response_protein_2 in SMMC-7721 and HepG2 cells .
19096044	0	miR-30d	91,98	insulin	102,109	miR-30d	insulin	407033	3630	Gene	Gene	START_ENTITY|nmod|transcription transcription|compound|END_ENTITY	Identification of glucose-regulated miRNAs from pancreatic -LCB- beta -RCB- cells reveals a role for miR-30d in insulin transcription .
24312366	0	miR-30e	18,25	Bmi1	41,45	miR-30e	Bmi1	407034	648	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Identification of miR-30e * regulation of Bmi1 expression mediated by tumor-associated macrophages in gastrointestinal_cancer .
25691332	0	miR-30e	29,36	CBL-B	116,121	miR-30e	CBL-B	407034	868	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Ionizing radiation-inducible miR-30e promotes glioma cell invasion through EGFR stabilization by directly targeting CBL-B .
25229239	0	miR-31	17,23	C/EBPb	36,42	miR-31	C/EBPb	407035	1051	Gene	Gene	START_ENTITY|nmod|cascade cascade|compound|END_ENTITY	EGF up-regulates miR-31 through the C/EBPb signal cascade in oral_carcinoma .
25362258	0	miR-31	0,6	E2F2	65,69	miR-31	E2F2	407035	1870	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-31 promotes proliferation of colon_cancer cells by targeting E2F2 .
24582497	0	miR-31	83,89	EMSY	27,31	miR-31	EMSY	407035	56946	Gene	Gene	represses|xcomp|START_ENTITY represses|nsubj|END_ENTITY	The breast_cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31 .
26731986	0	miR-31	0,6	HuR	81,84	miR-31	HuR	407035	1994	Gene	Gene	Growth|amod|START_ENTITY Growth|nmod|END_ENTITY	miR-31 Reduces Cell Growth of Papillary_Thyroid_Carcinoma by RNA-Binding Protein HuR .
23258531	0	miR-31	55,61	RhoBTB1	26,33	miR-31	RhoBTB1	407035	9886	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon_cancer .
20980827	0	miR-31	12,18	SATB2	39,44	miR-31	SATB2	407035	23314	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts .
26319141	0	miR-31	16,22	angiotensinogen	55,70	miR-31	angiotensinogen	407035	183	Gene	Gene	site|amod|START_ENTITY site|nmod|gene gene|compound|END_ENTITY	Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes .
21212803	0	miR-31	0,6	dystrophin	17,27	miR-31	dystrophin	407035	1756	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	miR-31 modulates dystrophin expression : new implications for Duchenne_muscular_dystrophy therapy .
22089331	0	miR-31	6,12	radixin	21,28	miR-31	radixin	407035	5962	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Human miR-31 targets radixin and inhibits migration and invasion of glioma cells .
22266859	0	miR-32	19,25	BTG2	34,38	miR-32	BTG2	407036	7832	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant_prostate_cancer .
27042117	0	miR-32	0,6	TWIST1	94,100	miR-32	TWIST1	407036	7291	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-32 inhibits proliferation , epithelial-mesenchymal transition , and metastasis by targeting TWIST1 in non-small-cell_lung_cancer cells .
23876508	0	miR-320a	0,8	SMAR1	73,78	miR-320a	SMAR1	407037	54971	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR-320a regulates erythroid differentiation through MAR binding protein SMAR1 .
23292865	0	miR-326	69,76	microRNA-326	40,52	miR-326	microRNA-326	442900	442900	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Expression and clinical significance of microRNA-326 in human glioma miR-326 expression in glioma .
23337504	0	miR-330	0,7	Cdc42	76,81	miR-330	Cdc42	442902	998	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR-330 regulates the proliferation of colorectal_cancer cells by targeting Cdc42 .
23232114	0	miR-335	23,30	BIRC5	47,52	miR-335	BIRC5	442904	332	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Genetic variation in a miR-335 binding site in BIRC5 alters susceptibility to lung_cancer in Chinese Han populations .
24737483	0	miR-335	24,31	PAX6	0,4	miR-335	PAX6	442904	5080	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	PAX6 , a novel target of miR-335 , inhibits cell proliferation and invasion in glioma cells .
20713524	0	miR-335	0,7	Rb1	25,28	miR-335	Rb1	442904	5925	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	miR-335 directly targets Rb1 -LRB- pRb/p105 -RRB- in a proximal connection to p53-dependent stress response .
22886530	0	miR-335	0,7	Rb1	58,61	miR-335	Rb1	442904	5925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas .
25183455	0	miR-337	0,7	HOXB7	98,103	miR-337	HOXB7	442905	3217	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-337 regulates the proliferation and invasion in pancreatic_ductal_adenocarcinoma by targeting HOXB7 .
25891797	0	miR-33a	0,7	HIF-1a	65,71	miR-33a	HIF-1a	407039	3091	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1a .
21743487	0	miR-33a	40,47	Pim-1	19,24	miR-33a	Pim-1	407039	5292	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The proto-oncogene Pim-1 is a target of miR-33a .
24475217	0	miR-342	0,7	BRCA1	18,23	miR-342	BRCA1	442909	672	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	miR-342 regulates BRCA1 expression through modulation of ID4 in breast_cancer .
23408138	0	miR-342	0,7	estrogen_receptor-a	27,46	miR-342	estrogen receptor-a	442909	2099	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	miR-342 is associated with estrogen_receptor-a expression and response to tamoxifen in breast_cancer .
24829923	0	miR-34a	38,45	Bcl-2	18,23	miR-34a	Bcl-2	407040	596	Gene	Gene	mediates|amod|START_ENTITY expression|nmod|mediates expression|compound|END_ENTITY	Downregulation of Bcl-2 expression by miR-34a mediates palmitate-induced Min6 cells apoptosis .
26091620	0	miR-34a	9,16	Bcl-2	128,133	miR-34a	Bcl-2	407040	596	Gene	Gene	enhanced|nsubj|START_ENTITY enhanced|nmod|neurotoxins neurotoxins|nmod|END_ENTITY	Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2 .
18406353	0	miR-34a	36,43	CCND1	18,23	miR-34a	CCND1	407040	595	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest .
21240262	0	miR-34a	13,20	CD44	95,99	miR-34a	CD44	723848(Tax:10090)	12505(Tax:10090)	Gene	Gene	prostate_cancer|amod|START_ENTITY stem|nsubj|prostate_cancer stem|advcl|repressing repressing|dobj|END_ENTITY	The microRNA miR-34a inhibits prostate_cancer stem cells and metastasis by directly repressing CD44 .
23314380	0	miR-34a	0,7	CD44	86,90	miR-34a	CD44	407040	960	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|repressing repressing|dobj|expression expression|nmod|END_ENTITY	miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44 .
24019906	0	miR-34a	84,91	CD44	4,8	miR-34a	CD44	723848(Tax:10090)	12505(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY enriched|nmod|expression enriched|nsubjpass|subsets subsets|compound|END_ENTITY	The CD44 -LRB- high -RRB- tumorigenic subsets in lung_cancer biospecimens are enriched for low miR-34a expression .
24116237	0	miR-34a	96,103	CD44	16,20	miR-34a	CD44	407040	960	Gene	Gene	Expression|amod|START_ENTITY Enriched|nmod|Expression END_ENTITY|acl:relcl|Enriched	Correction : The CD44 -LRB- high -RRB- Tumorigenic Subsets in Lung Cancer Biospecimens Are Enriched for Low miR-34a Expression .
26035691	0	miR-34a	107,114	CD44	115,119	miR-34a	CD44	407040	960	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Depletion of histone_deacetylase_1 inhibits metastatic abilities of gastric_cancer cells by regulating the miR-34a / CD44 pathway .
26231042	0	miR-34a	32,39	CD44	114,118	miR-34a	CD44	407040	960	Gene	Gene	prostate_cancer|amod|START_ENTITY stem|nsubj|prostate_cancer stem|advcl|repressing repressing|dobj|END_ENTITY	Registered report : the microRNA miR-34a inhibits prostate_cancer stem cells and metastasis by directly repressing CD44 .
24232982	0	miR-34a	27,34	FOXP1	62,67	miR-34a	FOXP1	407040	27086	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of miR-34a and its target proteins of FOXP1 , p53 , and BCL2 in gastric_MALT_lymphoma and DLBCL .
25878394	0	miR-34a	0,7	HNF4G	105,110	miR-34a	HNF4G	407040	3174	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-34a inhibits proliferation and invasion of bladder_cancer cells by targeting orphan nuclear receptor HNF4G .
25499621	0	miR-34a	17,24	PD-L1	33,38	miR-34a	PD-L1	407040	29126	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute_myeloid_leukemia .
18755897	0	miR-34a	0,7	SIRT1	22,27	miR-34a	SIRT1	407040	23411	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	miR-34a repression of SIRT1 regulates apoptosis .
25916635	0	miR-34a	87,94	SIRT1	95,100	miR-34a	SIRT1	723848(Tax:10090)	93759(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Carbon_monoxide protects against hepatic_ischemia / reperfusion injury by modulating the miR-34a / SIRT1 pathway .
26608583	0	miR-34a	122,129	SIRT1	130,135	miR-34a	SIRT1	723848(Tax:10090)	93759(Tax:10090)	Gene	Gene	Axis|amod|START_ENTITY Axis|compound|END_ENTITY	Isocaloric Pair-Fed High-Carbohydrate Diet Induced More Hepatic_Steatosis and Inflammation than High-Fat Diet Mediated by miR-34a / SIRT1 Axis in Mice .
26722316	0	miR-34a	0,7	SIRT1	76,81	miR-34a	SIRT1	407040	23411	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	miR-34a inhibits cell proliferation in prostate_cancer by downregulation of SIRT1 expression .
24583844	0	miR-34a	0,7	SIRT6	8,13	miR-34a	SIRT6	407040	51548	Gene	Gene	/|amod|START_ENTITY END_ENTITY|nsubj|/	miR-34a / SIRT6 in squamous differentiation and cancer .
26902620	0	miR-34a	95,102	Sirt1	0,5	miR-34a	Sirt1	723848(Tax:10090)	93759(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY attenuating|dobj|function inhibit|advcl|attenuating mRNA|acl|inhibit interacts|nmod|mRNA interacts|nsubj|lncRNA lncRNA|compound|END_ENTITY	Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a .
25954903	0	miR-34a	0,7	Yin_Yang-1	95,105	miR-34a	Yin Yang-1	407040	7528	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	miR-34a inhibits the migration and invasion of esophageal_squamous_cell_carcinoma by targeting Yin_Yang-1 .
24401748	0	miR-34a	0,7	p19	25,28	miR-34a	p19	723848(Tax:10090)	83430(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|END_ENTITY	miR-34a is essential for p19 -LRB- Arf -RRB- - driven cell cycle arrest .
23796712	0	miR-34a	36,43	p53	0,3	miR-34a	p53	407040	7157	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	p53 regulates glucose metabolism by miR-34a .
25213795	0	miR-34c	27,34	KITLG	0,5	miR-34c	KITLG	407042	4254	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	KITLG is a novel target of miR-34c that is associated with the inhibition of growth and invasion in colorectal_cancer cells .
25683915	0	miR-34c	13,20	stem_cell_factor	112,128	miR-34c	stem cell factor	100314014(Tax:10116)	60427(Tax:10116)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	The microRNA miR-34c inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia by targeting stem_cell_factor .
26772880	0	miR-367	0,7	PTEN	103,107	miR-367	PTEN	442912	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	miR-367 promotes proliferation and invasion of hepatocellular_carcinoma cells by negatively regulating PTEN .
24552534	0	miR-372	0,7	ATAD2	36,41	miR-372	ATAD2	442917	29028	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular_carcinoma proliferation and metastasis .
25714028	0	miR-372	0,7	p62	17,20	miR-372	p62	442917	8878	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	miR-372 inhibits p62 in head_and_neck_squamous_cell_carcinoma in vitro and in vivo .
21086164	0	miR-373	0,7	methyl-CpG-binding_domain_protein_2	29,64	miR-373	methyl-CpG-binding domain protein 2	442918	8932	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	miR-373 negatively regulates methyl-CpG-binding_domain_protein_2 -LRB- MBD2 -RRB- in hilar_cholangiocarcinoma .
22997891	0	miR-373	54,61	miR-143	45,52	miR-373	miR-143	442918	406935	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Differential expression of miR-21 , miR-126 , miR-143 , miR-373 in normal cervical tissue , cervical_cancer tissue and Hela cell -RSB- .
24053186	0	miR-374a	107,115	NAMPT	61,66	miR-374a	NAMPT	442919	10135	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Mechanical stress induces pre-B-cell_colony-enhancing_factor / NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium .
27059117	0	miR-375	0,7	BMPR2	79,84	miR-375	BMPR2	494324	659	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-375 negatively regulates porcine preadipocyte differentiation by targeting BMPR2 .
25001509	0	miR-375	31,38	Claudin-1	0,9	miR-375	Claudin-1	494324	9076	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Claudin-1 is a novel target of miR-375 in non-small-cell_lung_cancer .
25619565	0	miR-375	0,7	FZD8	52,56	miR-375	FZD8	100314263(Tax:10116)	364754(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts .
25184138	0	miR-375	0,7	IGF1R	19,24	miR-375	IGF1R	494324	3480	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	miR-375 suppresses IGF1R expression and contributes to inhibition of cell progression in laryngeal_squamous_cell_carcinoma .
23552692	0	miR-375	17,24	MYC	35,38	miR-375	MYC	494324	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions .
24746361	0	miR-375	18,25	SHOX2	0,5	miR-375	SHOX2	494324	6474	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	SHOX2 is a direct miR-375 target and a novel epithelial-to-mesenchymal transition inducer in breast_cancer cells .
21856745	0	miR-375	0,7	YAP1	42,46	miR-375	YAP1	494324	10413	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung_cancer .
24356001	0	miR-375	0,7	YAP1	81,85	miR-375	YAP1	723900(Tax:10090)	22601(Tax:10090)	Gene	Gene	inhibits|dep|START_ENTITY inhibits|nsubj|cells cells|acl|targeting targeting|dobj|END_ENTITY	miR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1 .
21106538	0	miR-377	53,60	heme_oxygenase-1	14,30	miR-377	heme oxygenase-1	494326	3162	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 protein expression by miR-377 in combination with miR-217 .
25471065	0	miR-378	8,15	p110a	24,29	miR-378	p110a	723889(Tax:10090)	18706(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Hepatic miR-378 targets p110a and controls glucose and lipid homeostasis by modulating hepatic insulin signalling .
23874748	0	miR-379	0,7	cyclin_B1	18,27	miR-379	cyclin B1	494328	891	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	miR-379 regulates cyclin_B1 expression and is decreased in breast_cancer .
26744330	0	miR-379	16,23	miR-410	24,31	miR-379	miR-410	723858(Tax:10090)	723863(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Deletion of the miR-379 / miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour .
23618224	0	miR-379	47,54	miR-656	55,62	miR-379	miR-656	494328	724026	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Genome-wide analysis reveals downregulation of miR-379 / miR-656 cluster in human cancers .
23816136	0	miR-381	0,7	WEE1	27,31	miR-381	WEE1	494330	7465	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|compound|END_ENTITY	miR-381 , a novel intrinsic WEE1 inhibitor , sensitizes renal_cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O .
26755660	0	miR-3923	105,113	KRAS	114,118	miR-3923	KRAS	100500877	3845	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic_cancer by derepressing the miR-3923 / KRAS pathway .
26744330	0	miR-410	24,31	miR-379	16,23	miR-410	miR-379	723863(Tax:10090)	723858(Tax:10090)	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Deletion of the miR-379 / miR-410 gene cluster at the imprinted Dlk1-Dio3 locus enhances anxiety-related behaviour .
26463631	0	miR-425	0,7	IGF-1	89,94	miR-425	IGF-1	494337	3479	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-425 inhibits melanoma metastasis through repression of PI3K-Akt pathway by targeting IGF-1 .
25550463	0	miR-429	22,29	hypoxia-inducible_factor-1a	40,67	miR-429	hypoxia-inducible factor-1a	554210	3091	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The hypoxia-inducible miR-429 regulates hypoxia-inducible_factor-1a expression in human endothelial cells through a negative feedback loop .
26215566	0	miR-431	0,7	Smad4	86,91	miR-431	Smad4	574038	4089	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4 .
18776219	0	miR-433	41,48	SHP	88,91	miR-433	SHP	574034	8431	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma .
26103953	0	miR-448	0,7	CXCL12	84,90	miR-448	CXCL12	554212	6387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-448 negatively regulates ovarian_cancer cell growth and metastasis by targeting CXCL12 .
26103953	0	miR-448	0,7	CXCL12	84,90	miR-448	CXCL12	554212	6387	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-448 negatively regulates ovarian_cancer cell growth and metastasis by targeting CXCL12 .
26375440	0	miR-449a	0,8	Calpain6	68,76	miR-449a	Calpain6	554213	827	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|down-regulation down-regulation|nmod|END_ENTITY	miR-449a promotes liver_cancer cell apoptosis by down-regulation of Calpain6 and POU2F1 .
26576674	0	miR-449a	0,8	Flot2	17,22	miR-449a	Flot2	554213	2319	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-449a targets Flot2 and inhibits gastric_cancer invasion by inhibiting TGF-b-mediated EMT .
19252524	0	miR-449a	0,8	HDAC-1	17,23	miR-449a	HDAC-1	554213	3065	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-449a targets HDAC-1 and induces growth_arrest in prostate_cancer .
23674142	0	miR-449b	0,8	CCND1	96,101	miR-449b	CCND1	693123	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|downregulation downregulation|nmod|expression expression|compound|END_ENTITY	miR-449b inhibits the proliferation of SW1116 colon_cancer stem cells through downregulation of CCND1 and E2F3 expression .
22179124	0	miR-451	9,16	CAB39	60,65	miR-451	CAB39	574411	51719	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|nmod|END_ENTITY	MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma .
26885274	0	miR-451	0,7	Ywhaz	53,58	miR-451	Ywhaz	574411	7534	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR-451 regulates FoxO3 nuclear accumulation through Ywhaz in human colorectal_cancer .
25497012	0	miR-466	0,7	Coxsackie_virus_and_Adenovirus_Receptor	42,81	miR-466	Coxsackie virus and Adenovirus Receptor	100423038	1525	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	miR-466 is putative negative regulator of Coxsackie_virus_and_Adenovirus_Receptor .
26585487	0	miR-4792	0,8	FOXC1	106,111	miR-4792	FOXC1	100616448	2296	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-4792 inhibits epithelial-mesenchymal transition and invasion in nasopharyngeal_carcinoma by targeting FOXC1 .
22510686	0	miR-484	0,7	Fis1	58,62	miR-484	Fis1	723916(Tax:10090)	66437(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR-484 regulates mitochondrial network through targeting Fis1 .
25561284	0	miR-491	49,56	EGFR	24,28	miR-491	EGFR	574444	1956	Gene	Gene	Activity|amod|START_ENTITY END_ENTITY|nmod|Activity	Ginsenoside_Rh2 Targets EGFR by Up-Regulation of miR-491 to Enhance Anti-tumor Activity in Hepatitis_B_Virus-Related Hepatocellular_Carcinoma .
26503214	0	miR-494	20,27	GALNT7	0,6	miR-494	GALNT7	723878(Tax:10090)	108150(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	GALNT7 , a target of miR-494 , participates in the oncogenesis of nasopharyngeal_carcinoma .
25500095	0	miR-494	0,7	HOXA10	18,24	miR-494	HOXA10	574452	3206	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	miR-494 represses HOXA10 expression and inhibits cell proliferation in oral_cancer .
20006626	0	miR-494	14,21	PTEN	37,41	miR-494	PTEN	574452	5728	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo -LRB- a -RRB- pyrene-trans-7 ,8 - dihydrodiol-9 ,10 - epoxide .
26045065	0	miR-494	0,7	PTEN	137,141	miR-494	PTEN	574452	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-494 promotes cell proliferation , migration and invasion , and increased sorafenib resistance in hepatocellular_carcinoma by targeting PTEN .
26686085	0	miR-494	91,98	PTEN	63,67	miR-494	PTEN	574452	5728	Gene	Gene	inhibition|nmod|START_ENTITY mRNA|nmod|inhibition mRNA|compound|END_ENTITY	Tumor-suppressor NFkB2_p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494 .
24177028	0	miR-494	39,46	SLC26A3	28,35	miR-494	SLC26A3	574452	1811	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Translational repression of SLC26A3 by miR-494 in intestinal epithelial cells .
24316134	0	miR-494	29,36	p190B_rhoGAP	107,119	miR-494	p190B rhoGAP	574452	394	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B_rhoGAP .
26486082	0	miR-497	28,35	ANLN	104,108	miR-497	ANLN	574456	54443	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal_carcinoma by targeting ANLN and HSPA4L .
22969914	0	miR-497	0,7	Bcl-w	62,67	miR-497	Bcl-w	574456	599	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	miR-497 induces apoptosis of breast_cancer cells by targeting Bcl-w .
24464213	0	miR-497	47,54	Checkpoint_kinase_1	0,19	miR-497	Checkpoint kinase 1	574456	1111	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Checkpoint_kinase_1 is negatively regulated by miR-497 in hepatocellular_carcinoma .
26700673	0	miR-497	0,7	Slug	84,88	miR-497	Slug	574456	6591	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-497 inhibits epithelial mesenchymal transition in breast_carcinoma by targeting Slug .
27015364	0	miR-497	62,69	VEGFA	70,75	miR-497	VEGFA	574456	7422	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Twist promotes angiogenesis in pancreatic_cancer by targeting miR-497 / VEGFA axis .
26933805	0	miR-498	73,80	BRCA1	95,100	miR-498	BRCA1	574460	672	Gene	Gene	START_ENTITY|advcl|regulating regulating|dobj|END_ENTITY	MicroRNA deregulation in triple negative breast_cancer reveals a role of miR-498 in regulating BRCA1 expression .
24059862	0	miR-499	98,105	MYH14	41,46	miR-499	MYH14	102466472	79784	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499 : muscle-specific miR-499 expression persists in the absence of the ancestral host gene .
22072795	0	miR-503	0,7	CUG-binding_protein_1	18,39	miR-503	CUG-binding protein 1	574506	10658	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	miR-503 represses CUG-binding_protein_1 translation by recruiting CUGBP1 mRNA to processing bodies .
26722476	0	miR-503	0,7	E2F3	98,102	miR-503	E2F3	574506	1871	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-503 inhibits cell proliferation and induces apoptosis in colorectal_cancer cells by targeting E2F3 .
26770450	0	miR-503	0,7	L1CAM	72,77	miR-503	L1CAM	574506	3897	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-503 inhibits cell proliferation and invasion in glioma by targeting L1CAM .
21927029	0	miR-504	96,103	FOXP1	104,109	miR-504	FOXP1	574507	27086	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Connective_tissue_growth_factor modulates oral_squamous_cell_carcinoma invasion by activating a miR-504 / FOXP1 signalling .
20542001	0	miR-504	56,63	p53	40,43	miR-504	p53	574507	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of tumor suppressor p53 by microRNA miR-504 .
26692944	0	miR-506	0,7	IGF2BP1	61,68	miR-506	IGF2BP1	574511	10642	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma .
26398880	0	miR-506	0,7	IQGAP1	61,67	miR-506	IQGAP1	574511	8826	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-506 regulates breast_cancer cell metastasis by targeting IQGAP1 .
25754817	0	miR-5100	0,8	Rab6	59,63	miR-5100	Rab6	100847014	5870	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	miR-5100 promotes tumor growth in lung_cancer by targeting Rab6 .
26336578	0	miR-511	8,15	OATP1B1	37,44	miR-511	OATP1B1	574445	10599	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Regulation Regulation|nmod|Expression Expression|compound|END_ENTITY	Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty_Acid .
26040940	0	miR-517a	30,38	miR-518b	73,81	miR-517a	miR-518b	574479	574474	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation .
26040940	0	miR-518b	73,81	miR-517a	30,38	miR-518b	miR-517a	574474	574479	Gene	Gene	Levels|nmod|START_ENTITY Levels|nmod|END_ENTITY	Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation .
24589589	0	miR-520a	1,9	ErbB4	20,25	miR-520a	ErbB4	574467	2066	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	-LSB- miR-520a regulates ErbB4 expression and suppresses proliferation and invasion of esophageal_squamous_cell_carcinoma -RSB- .
25733698	0	miR-526b	25,33	EP4	54,57	miR-526b	EP4	574468	5734	Gene	Gene	START_ENTITY|nmod|Activation Activation|compound|END_ENTITY	COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation .
27040768	0	miR-543	0,7	PTEN	94,98	miR-543	PTEN	100126335	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	miR-543 promotes proliferation and invasion of non-small_cell_lung_cancer cells by inhibiting PTEN .
26562529	0	miR-543	23,30	SIRT1	83,88	miR-543	SIRT1	100126335	23411	Gene	Gene	Down-regulation|nmod|START_ENTITY alleviates|nsubj|Down-regulation alleviates|advcl|targeting targeting|dobj|END_ENTITY	Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1 .
26612257	0	miR-543	0,7	SIRT1	64,69	miR-543	SIRT1	100126335	23411	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-543 promotes gastric_cancer cell proliferation by targeting SIRT1 .
26409456	0	miR-548n	13,21	SMAD4	23,28	miR-548n	SMAD4	100302152	4089	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
26409456	0	miR-548n	13,21	SMAD5	30,35	miR-548n	SMAD5	100302152	4090	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Zinc affects miR-548n , SMAD4 , SMAD5 expression in HepG2 hepatocyte and HEp-2 lung cell lines .
23430453	0	miR-570	2,9	B7-H1	43,48	miR-570	B7-H1	693155	29126	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|gene gene|compound|END_ENTITY	A miR-570 binding site polymorphism in the B7-H1 gene is associated with the risk of gastric_adenocarcinoma .
27036041	0	miR-590	0,7	RB1	103,106	miR-590	RB1	693175	5925	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	miR-590 promotes cell proliferation and invasion in T-cell_acute_lymphoblastic_leukaemia by inhibiting RB1 .
25681036	0	miR-603	0,7	WIF1	76,80	miR-603	WIF1	693188	11197	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|inhibiting inhibiting|dobj|END_ENTITY	miR-603 promotes glioma cell growth via Wnt/b-catenin pathway by inhibiting WIF1 and CTNNBIP1 .
26158514	0	miR-612	0,7	AKT2	82,86	miR-612	AKT2	693197	208	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-612 negatively regulates colorectal_cancer growth and metastasis by targeting AKT2 .
24751522	0	miR-613	0,7	LXRa	50,54	miR-613	LXRa	693198	10062	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-613 regulates cholesterol efflux by targeting LXRa and ABCA1 in PPARy activated THP-1 macrophages .
26068950	0	miR-620	0,7	15-hydroxyprostaglandin_dehydrogenase	52,89	miR-620	15-hydroxyprostaglandin dehydrogenase	693205	873	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin_dehydrogenase -LRB- HPGD -RRB- .
24682381	0	miR-620	42,49	GPC5	0,4	miR-620	GPC5	693205	2262	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	GPC5 , a tumor suppressor , is regulated by miR-620 in lung_adenocarcinoma .
25381221	0	miR-629	0,7	TRIM33	16,22	miR-629	TRIM33	693214	51592	Gene	Gene	Targets|amod|START_ENTITY END_ENTITY|nsubj|Targets	miR-629 Targets TRIM33 to Promote TGFb/Smad Signaling and Metastatic Phenotypes in ccRCC .
24655723	0	miR-630	0,7	IGF1R	16,21	miR-630	IGF1R	693215	3480	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast_cancer .
26328011	0	miR-630	0,7	LMO3	16,20	miR-630	LMO3	693215	55885	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-630 targets LMO3 to regulate cell growth and metastasis in lung_cancer .
25228385	0	miR-638	0,7	BRCA1	31,36	miR-638	BRCA1	693223	672	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast_cancer .
24623314	0	miR-638	0,7	Sp2	69,72	miR-638	Sp2	693223	6668	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|END_ENTITY	miR-638 suppresses cell proliferation in gastric_cancer by targeting Sp2 .
25130698	0	miR-639	0,7	FOXC1	134,139	miR-639	FOXC1	693224	2296	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-639 regulates transforming_growth_factor_beta-induced epithelial-mesenchymal transition in human tongue_cancer cells by targeting FOXC1 .
23091630	0	miR-644a	114,122	GAPDH	80,85	miR-644a	GAPDH	693229	2597	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	Housekeeping gene selection advisory : glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- and b-actin are targets of miR-644a .
25403488	0	miR-648	0,7	ET-1	16,20	miR-648	ET-1	693233	1906	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	miR-648 targets ET-1 mRNA and is co-transcriptionally regulated with MICAL3 by PAX5 .
23618224	0	miR-656	55,62	miR-379	47,54	miR-656	miR-379	724026	494328	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Genome-wide analysis reveals downregulation of miR-379 / miR-656 cluster in human cancers .
23953123	0	miR-663	29,36	H-ras	45,50	miR-663	H-ras	724033	3265	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	The epigenetically-regulated miR-663 targets H-ras in K-562 cells .
22776647	0	miR-663	19,26	VEGF	43,47	miR-663	VEGF	724033	7422	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Permissive role of miR-663 in induction of VEGF and activation of the ATF4 branch of unfolded protein response in endothelial cells by oxidized phospholipids .
27105517	0	miR-663a	126,134	p21	110,113	miR-663a	p21	724033	644914	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	ZNF224 , Kr ppel like zinc finger protein , induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a .
25735976	0	miR-664	0,7	PLP2	29,33	miR-664	PLP2	100302234	5355	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell_acute_lymphoblastic_leukaemia .
23864307	0	miR-675	0,7	Twist1	35,41	miR-675	Twist1	100033819	7291	Gene	Gene	downregulation|amod|START_ENTITY downregulation|nmod|END_ENTITY	miR-675 mediates downregulation of Twist1 and Rb in AFP-secreting hepatocellular_carcinoma .
23384942	0	miR-7	0,5	KLF4	81,85	miR-7	KLF4	10859	9314	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|modulating modulating|dobj|END_ENTITY	miR-7 suppresses brain metastasis of breast_cancer stem-like cells by modulating KLF4 .
24573489	0	miR-7	0,5	epidermal_growth_factor_receptor	82,114	miR-7	epidermal growth factor receptor	10859	1956	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	miR-7 inhibits the invasion and metastasis of gastric_cancer cells by suppressing epidermal_growth_factor_receptor expression .
26833707	0	miR-708	0,7	LSD1	8,12	miR-708	LSD1	100126333	23028	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	miR-708 / LSD1 axis regulates the proliferation and invasion of breast_cancer cells .
25008898	0	miR-758	104,111	Toll-like_receptors_3_and_7	56,83	miR-758	Toll-like receptors 3 and 7	768212	7098;51284	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Hepatitis_C virus infection decreases the expression of Toll-like_receptors_3_and_7 via upregulation of miR-758 .
23867156	0	miR-761	0,7	mitochondrial_fission_factor	57,85	miR-761	mitochondrial fission factor	100313892	56947	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-761 regulates the mitochondrial network by targeting mitochondrial_fission_factor .
20558762	0	miR-802	0,7	angiotensin_II_type_1_receptor	24,54	miR-802	angiotensin II type 1 receptor	768219	185	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	miR-802 regulates human angiotensin_II_type_1_receptor expression in intestinal epithelial C2BBe1 cells .
25680557	0	miR-873	26,33	miR-876	34,41	miR-873	miR-876	100126316	100126310	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Haploinsufficiency of the miR-873 / miR-876 microRNA cluster is associated with craniofacial_abnormalities .
27059301	0	miR-874	91,98	AQP3	63,67	miR-874	AQP3	100126343	360	Gene	Gene	sponging|xcomp|START_ENTITY regulate|advcl|sponging regulate|dobj|expression expression|compound|END_ENTITY	LncRNA H19 functions as a competing endogenous RNA to regulate AQP3 expression by sponging miR-874 in the intestinal barrier .
25680557	0	miR-876	34,41	miR-873	26,33	miR-876	miR-873	100126310	100126316	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Haploinsufficiency of the miR-873 / miR-876 microRNA cluster is associated with craniofacial_abnormalities .
25841337	0	miR-889	0,7	DAB2IP	78,84	miR-889	DAB2IP	100126345	153090	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	miR-889 promotes proliferation of esophageal_squamous_cell_carcinomas through DAB2IP .
22043236	0	miR-92	35,41	microRNA-92	22,33	miR-92	microRNA-92	407047	407047	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Regulatory Effects of microRNA-92 -LRB- miR-92 -RRB- on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear_Cell_Renal_Cell_Carcinoma .
22899845	0	miR-92b	0,7	Mef2	18,22	miR-92b	Mef2	12798263	36032(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|levels levels|amod|END_ENTITY	miR-92b regulates Mef2 levels through a negative-feedback circuit during Drosophila muscle development .
26993249	0	miR-92b	0,7	RECK	75,79	miR-92b	RECK	693235	8434	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-92b promotes tumor proliferation , migration , and invasion by targeting RECK in osteosarcoma .
26449498	0	miR-93	58,64	IL-8	14,18	miR-93	IL-8	407051	3576	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-8 gene expression in gliomas by microRNA miR-93 .
25183046	0	miR-93	74,80	TGF-beta	0,8	miR-93	TGF-beta	407051	7040	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	TGF-beta induced RBL2 expression in renal_cancer cells by down-regulating miR-93 .
24606633	0	miR-93	28,34	TGFbR2	0,6	miR-93	TGFbR2	407051	7048	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	TGFbR2 is a major target of miR-93 in nasopharyngeal_carcinoma aggressiveness .
26986724	0	miR-93-5p	9,18	IL-8	43,47	miR-93-5p	IL-8	100126325	3576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells .
27044823	0	miR-935	0,7	SOX7	64,68	miR-935	SOX7	100126325	83595	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-935 promotes gastric_cancer cell proliferation by targeting SOX7 .
24260486	0	miR-96	30,36	FOXO1	73,78	miR-96	FOXO1	407053	2308	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	The antiapoptotic function of miR-96 in prostate_cancer by inhibition of FOXO1 .
25451232	0	miR-96	0,6	HBEGF-EGFR	58,68	miR-96	HBEGF-EGFR	723886(Tax:10090)	15200;13649	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	miR-96 promotes osteogenic differentiation by suppressing HBEGF-EGFR signaling in osteoblastic cells .
24366472	0	miR-96	0,6	RECK	62,66	miR-96	RECK	407053	8434	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR-96 promotes tumor proliferation and invasion by targeting RECK in breast_cancer .
23385085	0	miR-960	11,18	Hedgehog	40,48	miR-960	Hedgehog	12798564	42737(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Drosophila miR-960 negatively regulates Hedgehog signaling by suppressing Smoothened , Costal-2 and Fused .
26263183	0	miR-98	0,6	Caspase-3	38,47	miR-98	Caspase-3	407054	836	Gene	Gene	target|nsubj|START_ENTITY target|dobj|END_ENTITY	miR-98 and its host gene Huwe1 target Caspase-3 in Silica nanoparticles-treated male germ cells .
26045772	0	miR-98	57,63	MCP-1	51,56	miR-98	MCP-1	407054	6347	Gene	Gene	IL-6|dep|START_ENTITY IL-6|compound|END_ENTITY	A crosstalk triggered by hypoxia and maintained by MCP-1 / miR-98 / IL-6 / p38 regulatory loop between human aortic smooth muscle cells and macrophages leads to aortic smooth muscle cells apoptosis via Stat1 activation .
26986073	0	miR-99a	0,7	NOX4	96,100	miR-99a	NOX4	407055	50507	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-99a regulates ROS-mediated invasion and migration_of_lung_adenocarcinoma cells by targeting NOX4 .
24365598	0	miR-99a	38,45	let-7c	46,52	miR-99a	let-7c	407055	406885	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Cardiomyogenesis is controlled by the miR-99a / let-7c cluster and epigenetic modifications .
26455324	0	miR-99a	37,44	let-7c	30,36	miR-99a	let-7c	407055	406885	Gene	Gene	progression|dep|START_ENTITY progression|amod|END_ENTITY	Genome-wide screen identified let-7c / miR-99a / miR-125b regulating tumor progression and stem-like properties in cholangiocarcinoma .
25348507	0	miR-99a	0,7	mTOR	29,33	miR-99a	mTOR	407055	21977(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	miR-99a directly targets the mTOR signalling pathway in breast_cancer side population cells .
26297545	0	miR-99b	0,7	IGF-1R	19,25	miR-99b	IGF-1R	407056	3480	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	miR-99b suppresses IGF-1R expression and contributes to inhibition of cell proliferation in human epidermal keratinocytes .
23233675	0	miR-99b	50,57	microRNA-99b	36,48	miR-99b	microRNA-99b	387230(Tax:10090)	387230(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Mycobacterium_tuberculosis controls microRNA-99b -LRB- miR-99b -RRB- expression in infected murine dendritic cells to modulate host immunity .
24525189	0	miR-9a	11,17	Dystroglycan	43,55	miR-9a	Dystroglycan	12797939	36773(Tax:7227)	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	Drosophila miR-9a targets the ECM receptor Dystroglycan to canalize myotendinous junction formation .
27011261	0	miR122	191,197	HNF-4a	184,190	miR122	HNF-4a	387231(Tax:10090)	15378(Tax:10090)	Gene	Gene	Pathway|compound|START_ENTITY Pathway|compound|END_ENTITY	Berberine Attenuates Development of the Hepatic Gluconeogenesis and Lipid Metabolism Disorder in Type 2 Diabetic Mice and in Palmitate-Incubated HepG2 Cells through Suppression of the HNF-4a miR122 Pathway .
21668589	0	miR126	0,6	Spred1	96,102	miR126	Spred1	387145(Tax:10090)	114715(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	miR126 positively regulates mast cell proliferation and cytokine production through suppressing Spred1 .
24562769	0	miR126-5p	0,9	ALCAM	24,29	miR126-5p	ALCAM	100302116	214	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	miR126-5p repression of ALCAM and SetD5 in endothelial cells regulates leucocyte adhesion and transmigration .
25323858	0	miR145	9,15	TGFBR2	26,32	miR145	TGFBR2	387163(Tax:10090)	21813(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|compound|END_ENTITY	MicroRNA miR145 Regulates TGFBR2 Expression and Matrix Synthesis in Vascular Smooth Muscle Cells .
25187057	0	miR181c	0,7	Six2	101,105	miR181c	Six2	406957	10736	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miR181c promotes apoptosis and suppresses proliferation of metanephric mesenchyme cells by targeting Six2 in vitro .
24786790	0	miR200c	41,48	Pin1	17,21	miR200c	Pin1	406985	5300	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast_cancer .
25663948	0	miR21	17,22	RECK	12,16	miR21	RECK	406991	8434	Gene	Gene	Cell|compound|START_ENTITY Cell|compound|END_ENTITY	Controlling RECK miR21 Promotes Tumor Cell Invasion and Is Related to Biochemical Recurrence in Prostate_Cancer .
25488748	0	miR30a	0,6	LOX	16,19	miR30a	LOX	407029	4015	Gene	Gene	Inhibits|nsubj|START_ENTITY Inhibits|dobj|Expression Expression|compound|END_ENTITY	miR30a Inhibits LOX Expression and Anaplastic Thyroid Cancer Progression .
25627976	0	miR340	0,6	Tissue_Plasminogen_Activator	86,114	miR340	Tissue Plasminogen Activator	442908	100128998	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|nmod|END_ENTITY	miR340 Suppresses the Stem-like Cell Function of Glioma-Initiating Cells by Targeting Tissue_Plasminogen_Activator .
25955681	0	miRNA-122	38,47	IL1A	68,72	miRNA-122	IL1A	406906	3552	Gene	Gene	Site|amod|START_ENTITY Site|nmod|END_ENTITY	An Insertion/Deletion Polymorphism at miRNA-122 Binding Site in the IL1A Is Associated with a Reduced Risk of Cervical_Squamous_Cell_Carcinoma .
22350415	0	miRNA-130a	0,10	ATG2B	19,24	miRNA-130a	ATG2B	406919	55102	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic_lymphocytic_leukemia cells .
24953832	0	miRNA-130a	89,99	HOTAIR	20,26	miRNA-130a	HOTAIR	406919	100124700	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Long non-coding RNA HOTAIR , a c-Myc activated driver of malignancy , negatively regulates miRNA-130a in gallbladder_cancer .
23430586	0	miRNA-182	38,47	profilin_1	112,122	miRNA-182	profilin 1	406958	5216	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Expression and regulatory function of miRNA-182 in triple-negative_breast_cancer cells through its targeting of profilin_1 .
25889892	0	miRNA-196b	0,10	IGF2BP1	89,96	miRNA-196b	IGF2BP1	442920	10642	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1 .
25889892	0	miRNA-196b	0,10	IGF2BP1	89,96	miRNA-196b	IGF2BP1	442920	10642	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1 .
22514743	0	miRNA-203	30,39	SNAI1	40,45	miRNA-203	SNAI1	406986	6615	Gene	Gene	loop|amod|START_ENTITY loop|compound|END_ENTITY	A novel network integrating a miRNA-203 / SNAI1 feedback loop which regulates epithelial to mesenchymal transition .
26191221	0	miRNA-221	0,9	TIMP2	70,75	miRNA-221	TIMP2	407006	7077	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miRNA-221 promotes proliferation , migration and invasion by targeting TIMP2 in renal_cell_carcinoma .
21628394	0	miRNA-223	0,9	EPB41L3	88,95	miRNA-223	EPB41L3	407008	23136	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	miRNA-223 promotes gastric_cancer invasion and metastasis by targeting tumor suppressor EPB41L3 .
24866595	0	miRNA-34a	0,9	CD44	68,72	miRNA-34a	CD44	407040	960	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|nmod|END_ENTITY	miRNA-34a Suppresses Cell Proliferation and Metastasis by Targeting CD44 in Human Renal_Carcinoma Cells .
18252210	0	miRNA-433	17,26	FGF20	43,48	miRNA-433	FGF20	574034	26281	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson_disease by overexpression of alpha-synuclein .
21572098	0	miRNA-92	15,23	DICKKOPF-3	67,77	miRNA-92	DICKKOPF-3	407047	27122	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 -LRB- DKK3 -RRB- in neuroblastoma .
23493574	0	miRNA-93	0,8	GLUT4	18,23	miRNA-93	GLUT4	407051	6517	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	miRNA-93 inhibits GLUT4 and is overexpressed in adipose_tissue of polycystic_ovary_syndrome patients and women with insulin resistance .
20610624	0	miRNA-96	0,8	KRAS	20,24	miRNA-96	KRAS	407053	3845	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic_cancer .
24606718	0	miRNA21	57,64	Bcl-2	87,92	miRNA21	Bcl-2	406991	596	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|compound|END_ENTITY	Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast_cancer cells .
17721077	0	miRNA_221	25,34	p27Kip1	14,21	miRNA 221	p27Kip1	407006	1027	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of p27Kip1 by miRNA_221 / 222 in glioblastoma .
26692938	0	microRNA-1	14,24	Bcl-2	117,122	microRNA-1	Bcl-2	100314077(Tax:10116)	24224(Tax:10116)	Gene	Gene	attenuates|amod|START_ENTITY Inhibition|nmod|attenuates hypoxia/re-oxygenation-induced|nsubj|Inhibition hypoxia/re-oxygenation-induced|advcl|targeting targeting|dobj|END_ENTITY	Inhibition of microRNA-1 attenuates hypoxia/re-oxygenation-induced apoptosis of cardiomyocytes by directly targeting Bcl-2 but not GADD45Beta .
26137045	0	microRNA-126	0,12	PAK4	24,28	microRNA-126	PAK4	406913	10298	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	microRNA-126 suppresses PAK4 expression in ovarian_cancer SKOV3 cells .
25433493	0	microRNA-133b	12,25	FSCN1	46,51	microRNA-133b	FSCN1	442890	6624	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of microRNA-133b and its target gene FSCN1 in gastric_cancer .
25025684	0	microRNA-135b	22,35	c-myc	44,49	microRNA-135b	c-myc	442891	4609	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	The tumor-suppressive microRNA-135b targets c-myc in osteoscarcoma .
24863965	0	microRNA-146a	27,40	CARD10	49,55	microRNA-146a	CARD10	406938	29775	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Lipopolysaccharide-induced microRNA-146a targets CARD10 and regulates angiogenesis in human umbilical vein endothelial cells .
20937840	0	microRNA-146a	93,106	IRAK-1	71,77	microRNA-146a	IRAK-1	406938	3654	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of interleukin-1_receptor-associated_kinase-1 -LRB- IRAK-1 -RRB- and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer_disease .
22711166	0	microRNA-146a	0,13	L1_cell_adhesion_molecule	26,51	microRNA-146a	L1 cell adhesion molecule	406938	3897	Gene	Gene	targets|nsubj|START_ENTITY targets|dobj|END_ENTITY	microRNA-146a targets the L1_cell_adhesion_molecule and suppresses the metastatic potential of gastric_cancer .
23878869	0	microRNA-146a	27,40	tumor_necrosis_factor-a	58,81	microRNA-146a	tumor necrosis factor-a	100314241(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of transfection of microRNA-146a on expression of tumor_necrosis_factor-a in alveolar macrophages -RSB- .
27049919	0	microRNA-149	0,12	caspase-2	21,30	microRNA-149	caspase-2	406941	835	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	microRNA-149 targets caspase-2 in glioma progression .
21946536	0	microRNA-155	57,69	BRCA1	17,22	microRNA-155	BRCA1	406947	672	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155 .
23970205	0	microRNA-155	0,12	FOXO3a	68,74	microRNA-155	FOXO3a	406947	2309	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	microRNA-155 regulates cell proliferation and invasion by targeting FOXO3a in glioma .
24351865	0	microRNA-155	32,44	SOCS1	53,58	microRNA-155	SOCS1	406947	8651	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	Rheumatoid_arthritis-associated microRNA-155 targets SOCS1 and upregulates TNF-a and IL-1b in PBMCs .
21385848	0	microRNA-155	33,45	c-Fos	13,18	microRNA-155	c-Fos	406947	2353	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function .
26620207	0	microRNA-155_and_suppressor_of_cytokine_signaling_1	39,90	SOCS1	92,97	microRNA-155 and suppressor of cytokine signaling 1	SOCS1	406947;8651	8651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Simultaneously increased expression of microRNA-155_and_suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- gene in the peripheral blood mononuclear cells of patients with primary Sj gren 's syndrome .
25901555	0	microRNA-15b	81,93	MMP-9	112,117	microRNA-15b	MMP-9	406949	4318	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Mangiferin regulates proliferation and apoptosis in glioma cells by induction of microRNA-15b and inhibition of MMP-9 expression .
19944013	0	microRNA-16-1	56,69	cyclin_E1	23,32	microRNA-16-1	cyclin E1	406950	898	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Down-regulation of the cyclin_E1 oncogene expression by microRNA-16-1 induces cell cycle arrest in human cancer cells .
23877371	0	microRNA-182	18,30	programmed_cell_death_4	78,101	microRNA-182	programmed cell death 4	406958	27250	Gene	Gene	Downregulation|nmod|START_ENTITY inhibits|nsubj|Downregulation inhibits|advcl|targeting targeting|dobj|END_ENTITY	Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed_cell_death_4 in human lung_adenocarcinoma cells .
22169280	0	microRNA-193b	11,24	C-KIT	28,33	microRNA-193b	C-KIT	574455	3815	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of microRNA-193b on C-KIT protein expression and biological behaviors of K562 cells -RSB- .
25119742	0	microRNA-193b	112,125	amyloid_precursor_protein	32,57	microRNA-193b	amyloid precursor protein	574455	351	Gene	Gene	biomarker|nsubj|START_ENTITY derived|ccomp|biomarker fluid|acl|derived END_ENTITY|nmod|fluid	MicroRNA-193b is a regulator of amyloid_precursor_protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer 's _ disease .
25985117	0	microRNA-19a	108,120	Cyclin_D1	121,130	microRNA-19a	Cyclin D1	406979	595	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	A systematic investigation based on microRNA-mediated gene regulatory network reveals that dysregulation of microRNA-19a / Cyclin_D1 axis confers an oncogenic potential and a worse prognosis in human hepatocellular_carcinoma .
24821285	0	microRNA-200c	0,13	XIAP	28,32	microRNA-200c	XIAP	406985	331	Gene	Gene	downregulates|amod|START_ENTITY END_ENTITY|nsubj|downregulates	microRNA-200c downregulates XIAP expression to suppress proliferation and promote apoptosis of triple-negative breast_cancer cells .
26323722	0	microRNA-204	16,28	SOX4	135,139	microRNA-204	SOX4	406987	6659	Gene	Gene	inhibits|amod|START_ENTITY Upregulation|nmod|inhibits cell|nsubj|Upregulation cell|advcl|downregulating downregulating|dobj|END_ENTITY	Upregulation of microRNA-204 inhibits cell proliferation , migration and invasion in human renal_cell_carcinoma cells by downregulating SOX4 .
26464665	0	microRNA-204	0,12	SOX4	99,103	microRNA-204	SOX4	406987	6659	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	microRNA-204 inhibits cell proliferation in T-cell_acute_lymphoblastic_leukemia by down-regulating SOX4 .
19276373	0	microRNA-205	0,12	HER3	23,27	microRNA-205	HER3	406988	2065	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	microRNA-205 regulates HER3 in human breast_cancer .
26325180	0	microRNA-206	37,49	c-Met	19,24	microRNA-206	c-Met	406989	4233	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of c-Met and Bcl2 by microRNA-206 , activates apoptosis , and inhibits tumor cell proliferation , migration and colony formation .
24137001	0	microRNA-208b	12,25	Polycomb-group_protein	41,63	microRNA-208b	Polycomb-group protein	100124433(Tax:10090)	211961(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The primary microRNA-208b interacts with Polycomb-group_protein , Ezh2 , to regulate gene expression in the heart .
22648654	0	microRNA-20a	16,28	ERK	50,53	microRNA-20a	ERK	406982	5594	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Hypoxia-induced microRNA-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells .
19308091	0	microRNA-21	15,26	BMP-6	0,5	microRNA-21	BMP-6	406991	654	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	BMP-6 inhibits microRNA-21 expression in breast_cancer through repressing deltaEF1 and AP-1 .
22158624	0	microRNA-21	89,100	Bone_morphogenetic_protein_4	0,28	microRNA-21	Bone morphogenetic protein 4	406991	652	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Bone_morphogenetic_protein_4 promotes vascular smooth muscle contractility by activating microRNA-21 -LRB- miR-21 -RRB- , which down-regulates expression of family of dedicator of cytokinesis -LRB- DOCK -RRB- proteins .
24327270	0	microRNA-21	39,50	Clusterin	0,9	microRNA-21	Clusterin	406991	1191	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Clusterin is a gene-specific target of microRNA-21 in head_and_neck_squamous_cell_carcinoma .
21088996	0	microRNA-21	13,24	PDCD4	111,116	microRNA-21	PDCD4	406991	27250	Gene	Gene	Knockdown|nmod|START_ENTITY inhibits|nsubj|Knockdown inhibits|dobj|death death|nmod|programmed_cell_death_4 programmed_cell_death_4|appos|END_ENTITY	Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed_cell_death_4 -LRB- PDCD4 -RRB- in pancreatic_ductal_adenocarcinoma .
21983937	0	microRNA-21	15,26	PDCD4	56,61	microRNA-21	PDCD4	406991	27250	Gene	Gene	expression|amod|START_ENTITY Association|nmod|expression Association|nmod|targets targets|appos|END_ENTITY	Association of microRNA-21 expression with its targets , PDCD4 and TIMP3 , in pancreatic_ductal_adenocarcinoma .
22267128	0	microRNA-21	65,76	PDCD4	27,32	microRNA-21	PDCD4	406991	27250	Gene	Gene	patients|amod|START_ENTITY significance|nmod|patients significance|nmod|expression expression|compound|END_ENTITY	Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes ' stage of colorectal_cancer patients .
23827854	0	microRNA-21	81,92	PDCD4	127,132	microRNA-21	PDCD4	406991	27250	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Aldose reductase inhibition suppresses colon_cancer cell viability by modulating microRNA-21 mediated programmed_cell_death_4 -LRB- PDCD4 -RRB- expression .
26943153	0	microRNA-21	126,137	PDCD4	88,93	microRNA-21	PDCD4	406991	27250	Gene	Gene	Up-Regulation|nmod|START_ENTITY Up-Regulation|compound|END_ENTITY	PDGF-BB Enhances the Proliferation of Cells in Human Orbital Fibroblasts by Suppressing PDCD4 Expression Via Up-Regulation of microRNA-21 .
19072831	0	microRNA-21	109,120	PTEN	99,103	microRNA-21	PTEN	406991	5728	Gene	Gene	up-regulation|amod|START_ENTITY phosphatase|nmod|up-regulation phosphatase|appos|END_ENTITY	Unsaturated fatty_acids inhibit the expression of tumor suppressor phosphatase and tensin homolog -LRB- PTEN -RRB- via microRNA-21 up-regulation in hepatocytes .
21104017	0	microRNA-21	8,19	PTEN	34,38	microRNA-21	PTEN	406991	5728	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of microRNA-21 and effect on PTEN in Kazakh 's esophageal_squamous_cell_carcinoma .
22213145	0	microRNA-21	108,119	PTEN	79,83	microRNA-21	PTEN	406991	5728	Gene	Gene	decreasing|xcomp|START_ENTITY increases|advcl|decreasing increases|dobj|END_ENTITY	Ars2 is overexpressed in human cholangiocarcinomas and its depletion increases PTEN and PDCD4 by decreasing microRNA-21 .
22267008	0	microRNA-21	0,11	PTEN	85,89	microRNA-21	PTEN	406991	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	microRNA-21 promotes tumor proliferation and invasion in gastric_cancer by targeting PTEN .
22770403	0	microRNA-21	40,51	PTEN	0,4	microRNA-21	PTEN	406991	5728	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma .
22879939	0	microRNA-21	16,27	PTEN	37,41	microRNA-21	PTEN	406991	5728	Gene	Gene	utilizes|amod|START_ENTITY END_ENTITY|nsubj|utilizes	TGFb-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion .
23226804	0	microRNA-21	0,11	PTEN	74,78	microRNA-21	PTEN	406991	5728	Gene	Gene	overexpression|amod|START_ENTITY contributes|nsubj|overexpression contributes|advcl|targeting targeting|dobj|END_ENTITY	microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid_endometrial_cancer .
24154840	0	microRNA-21	4,15	PTEN	16,20	microRNA-21	PTEN	406991	5728	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	The microRNA-21 / PTEN pathway regulates the sensitivity of HER2-positive_gastric_cancer cells to trastuzumab .
25845681	0	microRNA-21	88,99	PTEN	113,117	microRNA-21	PTEN	406991	5728	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	Icariin regulates the proliferation and apoptosis of human ovarian_cancer cells through microRNA-21 by targeting PTEN , RECK and Bcl-2 .
26230405	0	microRNA-21	0,11	PTEN	75,79	microRNA-21	PTEN	406991	5728	Gene	Gene	Proliferation|amod|START_ENTITY Talk|nsubj|Proliferation Talk|nmod|END_ENTITY	microRNA-21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder_Cancer .
24939570	0	microRNA-21	124,135	monocyte_chemotactic_protein-1	80,110	microRNA-21	monocyte chemotactic protein-1	406991	6347	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte_chemotactic_protein-1 induction of microRNA-21 .
21088996	0	microRNA-21	13,24	programmed_cell_death_4	86,109	microRNA-21	programmed cell death 4	406991	27250	Gene	Gene	Knockdown|nmod|START_ENTITY inhibits|nsubj|Knockdown inhibits|dobj|death death|nmod|END_ENTITY	Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed_cell_death_4 -LRB- PDCD4 -RRB- in pancreatic_ductal_adenocarcinoma .
23827854	0	microRNA-21	81,92	programmed_cell_death_4	102,125	microRNA-21	programmed cell death 4	406991	27250	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Aldose reductase inhibition suppresses colon_cancer cell viability by modulating microRNA-21 mediated programmed_cell_death_4 -LRB- PDCD4 -RRB- expression .
24786924	0	microRNA-21	33,44	programmed_cell_death_4	101,124	microRNA-21	programmed cell death 4	406991	27250	Gene	Gene	expression|nmod|START_ENTITY associated|nsubj|expression associated|nmod|expression expression|amod|END_ENTITY	Higher expression of whole blood microRNA-21 in patients with ankylosing_spondylitis associated with programmed_cell_death_4 mRNA expression and collagen cross-linked C-telopeptide concentration .
24959246	0	microRNA-21	14,25	programmed_cell_death_4	56,79	microRNA-21	programmed cell death 4	406991	27250	Gene	Gene	Inhibition|nmod|START_ENTITY upregulates|nsubj|Inhibition upregulates|dobj|expression expression|nmod|tensin tensin|amod|END_ENTITY	Inhibition of microRNA-21 upregulates the expression of programmed_cell_death_4 and phosphatase tensin homologue in the A431 squamous_cell_carcinoma cell line .
22575656	0	microRNA-210	0,12	NF-kB1	99,105	microRNA-210	NF-kB1	387206(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-kB1 in murine macrophages .
25869101	0	microRNA-217	0,12	EZH2	73,77	microRNA-217	EZH2	406999	2146	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|downregulating downregulating|dobj|END_ENTITY	microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric_cancer .
24576947	0	microRNA-223	16,28	ICAM-1	39,45	microRNA-223	ICAM-1	723814(Tax:10090)	15894(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells .
24999187	0	microRNA-24-1	19,32	FOXM1	86,91	microRNA-24-1	FOXM1	407012	2305	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Tumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder_cancer .
26416661	0	microRNA-25	9,20	RGS3	73,77	microRNA-25	RGS3	407014	5998	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Elevated microRNA-25 inhibits cell apoptosis in lung_cancer by targeting RGS3 .
21264258	0	microRNA-26b	8,20	EphA2	74,79	microRNA-26b	EphA2	407017	1969	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of microRNA-26b in glioma development and its mediated regulation on EphA2 .
24054330	0	microRNA-29	38,49	NOD2	25,29	microRNA-29	NOD2	407021	64127	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release .
22095944	0	microRNA-29	15,26	TGF-b1	41,47	microRNA-29	TGF-b1	407021	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of microRNA-29 expression by TGF-b1 promotes collagen expression and renal_fibrosis .
21138859	0	microRNA-296	34,46	HMGA1	14,19	microRNA-296	HMGA1	407022	3159	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regulation of HMGA1 expression by microRNA-296 affects prostate_cancer growth and invasion .
24870742	0	microRNA-29c	16,28	BCL-2	82,87	microRNA-29c	BCL-2	407026	596	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|regulating regulating|dobj|END_ENTITY	Exosome-derived microRNA-29c induces apoptosis of BIU-87 cells by down regulating BCL-2 and MCL-1 .
26862847	0	microRNA-29c	52,64	miR-29c	66,73	microRNA-29c	miR-29c	407026	407026	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Clinical response to azacitidine therapy depends on microRNA-29c -LRB- miR-29c -RRB- expression in older acute myeloid leukemia -LRB- AML -RRB- patients .
24315818	0	microRNA-301a	12,25	PTEN	82,86	microRNA-301a	PTEN	407027	5728	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|targeting targeting|dobj|END_ENTITY	Upregulated microRNA-301a in breast_cancer promotes tumor metastasis by targeting PTEN and activating Wnt/b-catenin signaling .
26494556	0	microRNA-31	17,28	Smad4	74,79	microRNA-31	Smad4	407035	4089	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Tumor suppressor microRNA-31 inhibits gastric_carcinogenesis by targeting Smad4 and SGPP2 .
25356868	0	microRNA-320	0,12	RUNX2	13,18	microRNA-320	RUNX2	407037	860	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	microRNA-320 / RUNX2 axis regulates adipocytic differentiation of human mesenchymal -LRB- skeletal -RRB- stem cells .
23292865	0	microRNA-326	40,52	miR-326	69,76	microRNA-326	miR-326	442900	442900	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Expression and clinical significance of microRNA-326 in human glioma miR-326 expression in glioma .
22684561	0	microRNA-34a	22,34	Notch1	120,126	microRNA-34a	Notch1	407040	4851	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of microRNA-34a on cell migration and invasion of invasive urothelial_bladder_carcinoma by targeting Notch1 .
24765202	0	microRNA-34a	17,29	Notch1	71,77	microRNA-34a	Notch1	407040	4851	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	Tumor suppressor microRNA-34a inhibits cell proliferation by targeting Notch1 in renal_cell_carcinoma .
26823698	0	microRNA-377	0,12	AEG-1	67,72	microRNA-377	AEG-1	494326	92140	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	microRNA-377 inhibits non-small-cell lung_cancer through targeting AEG-1 .
25351256	0	microRNA-429	18,30	p27Kip1	72,79	microRNA-429	p27Kip1	554210	1027	Gene	Gene	Downregulation|nmod|START_ENTITY inhibits|nsubj|Downregulation inhibits|advcl|targeting targeting|dobj|END_ENTITY	Downregulation of microRNA-429 inhibits cell proliferation by targeting p27Kip1 in human prostate_cancer cells .
26840372	0	microRNA-497	0,12	vascular_endothelial_growth_factor-A	86,122	microRNA-497	vascular endothelial growth factor-A	574456	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|targeting targeting|dobj|END_ENTITY	microRNA-497 inhibits invasion and metastasis of colorectal_cancer cells by targeting vascular_endothelial_growth_factor-A .
26998012	0	microRNA-503	24,36	kangai-1	63,71	microRNA-503	kangai-1	574506	3732	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of microRNA-503 and reduced expression of kangai-1 in B-cell_non-Hodgkin 's _ lymphoma .
26609477	0	microRNA-506	0,12	F-spondin_1	102,113	microRNA-506	F-spondin 1	574511	10418	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|targeting targeting|dobj|END_ENTITY	microRNA-506 regulates proliferation , migration and invasion in hepatocellular_carcinoma by targeting F-spondin_1 -LRB- SPON1 -RRB- .
26269755	0	microRNA-544	36,48	KLF4	21,25	microRNA-544	KLF4	664613	9314	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Transcription factor KLF4 regulates microRNA-544 that targets YWHAZ in cervical_cancer .
27022736	0	microRNA-595	85,97	Sox17	98,103	microRNA-595	Sox17	693180	64321	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Interleukin-22 promotes papillary_thyroid_cancer cell migration and invasion through microRNA-595 / Sox17 axis .
22527881	0	microRNA-675	34,46	H19	14,17	microRNA-675	H19	100033819	283120	Gene	Gene	Regulation|amod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions .
22043236	0	microRNA-92	22,33	VHL	46,49	microRNA-92	VHL	407047	7428	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|Expression Expression|compound|END_ENTITY	Regulatory Effects of microRNA-92 -LRB- miR-92 -RRB- on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear_Cell_Renal_Cell_Carcinoma .
22043236	0	microRNA-92	22,33	miR-92	35,41	microRNA-92	miR-92	407047	407047	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Regulatory Effects of microRNA-92 -LRB- miR-92 -RRB- on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear_Cell_Renal_Cell_Carcinoma .
25531317	0	microRNA-96	84,95	mTOR	118,122	microRNA-96	mTOR	407053	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Transforming_growth_factor-b promotes prostate bone metastasis through induction of microRNA-96 and activation of the mTOR pathway .
23233675	0	microRNA-99b	36,48	miR-99b	50,57	microRNA-99b	miR-99b	387230(Tax:10090)	387230(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Mycobacterium_tuberculosis controls microRNA-99b -LRB- miR-99b -RRB- expression in infected murine dendritic cells to modulate host immunity .
18716031	0	microRNA23b	110,121	mu_opioid_receptor	41,59	microRNA23b	mu opioid receptor	387217(Tax:10090)	18390(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Post-transcriptional regulation of mouse mu_opioid_receptor -LRB- MOR1 -RRB- via its 3 ' untranslated region : a role for microRNA23b .
23880186	0	microRNA_miR-132	4,20	Lrrfip1	29,36	microRNA miR-132	Lrrfip1	100314029(Tax:10116)	367314(Tax:10116)	Gene	Gene	targets|amod|START_ENTITY END_ENTITY|nsubj|targets	The microRNA_miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia .
22139841	0	microcephalin	39,52	MCPH1	54,59	microcephalin	MCPH1	79648	79648	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Molecular basis for the association of microcephalin -LRB- MCPH1 -RRB- protein with the cell_division_cycle_protein_27 -LRB- Cdc27 -RRB- subunit of the anaphase-promoting complex .
3315986	0	microfibril-associated_glycoprotein	40,75	MAGP	77,81	microfibril-associated glycoprotein	MAGP	281912(Tax:9913)	281912(Tax:9913)	Gene	Gene	localisation|nmod|START_ENTITY localisation|appos|END_ENTITY	The immunohistochemical localisation of microfibril-associated_glycoprotein -LRB- MAGP -RRB- in elastic and non-elastic tissues .
18322703	0	microfibril-associated_glycoprotein	39,74	MFAP4	84,89	microfibril-associated glycoprotein	MFAP4	287382(Tax:10116)	287382(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential gene expression of 36-kDa microfibril-associated_glycoprotein -LRB- MAGP-36 / MFAP4 -RRB- in rat organs .
10664011	0	microfibril-associated_glycoprotein-1	14,51	MAGP-1	53,59	microfibril-associated glycoprotein-1	MAGP-1	4237	4237	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of microfibril-associated_glycoprotein-1 -LRB- MAGP-1 -RRB- in human epidermal keratinocytes .
10723723	0	microfibril-associated_glycoprotein-2	26,63	MAGP-2	65,71	microfibril-associated glycoprotein-2	MAGP-2	50530(Tax:10090)	50530(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Organization of the mouse microfibril-associated_glycoprotein-2 -LRB- MAGP-2 -RRB- gene .
15560107	0	microfibril-associated_glycoprotein_1	52,89	MAGP-1	91,97	microfibril-associated glycoprotein 1	MAGP-1	281912(Tax:9913)	281912(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The pattern of fibrillin deposition correlates with microfibril-associated_glycoprotein_1 -LRB- MAGP-1 -RRB- expression in cultured blood and lymphatic endothelial cells .
26899386	0	microfibrillar-associated_protein_4	12,47	MFAP4	49,54	microfibrillar-associated protein 4	MFAP4	76293(Tax:10090)	76293(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of microfibrillar-associated_protein_4 -LRB- MFAP4 -RRB- in the formation and function of splenic compartments during embryonic and adult life .
18829533	0	microphthalmia-associated_transcription_factor	16,62	Brn-2	0,5	microphthalmia-associated transcription factor	Brn-2	4286	5454	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Brn-2 represses microphthalmia-associated_transcription_factor expression and marks a distinct subpopulation of microphthalmia-associated_transcription_factor-negative melanoma cells .
10694430	0	microphthalmia-associated_transcription_factor	14,60	MITF	61,65	microphthalmia-associated transcription factor	MITF	4286	4286	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of microphthalmia-associated_transcription_factor MITF protein levels by association with the ubiquitin-conjugating enzyme hUBC9 .
25414259	0	microphthalmia-associated_transcription_factor	37,83	MITF	85,89	microphthalmia-associated transcription factor	MITF	4286	4286	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	MicroRNA-340-mediated degradation of microphthalmia-associated_transcription_factor -LRB- MITF -RRB- mRNA is inhibited by coding_region_determinant-binding_protein -LRB- CRD-BP -RRB- .
10747853	0	microphthalmia-associated_transcription_factor	33,79	Wnt-3a	83,89	microphthalmia-associated transcription factor	Wnt-3a	4286	89780	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of melanocyte-specific microphthalmia-associated_transcription_factor by Wnt-3a .
26278531	0	microphthalmia-associated_transcription_factor	106,152	tyrosinase	186,196	microphthalmia-associated transcription factor	tyrosinase	17342(Tax:10090)	22173(Tax:10090)	Gene	Gene	glycogen_synthase_kinase_3_beta|dep|START_ENTITY END_ENTITY|nsubj|glycogen_synthase_kinase_3_beta	N - -LRB- 4-bromophenethyl -RRB- _ caffeamide inhibits melanogenesis by regulating AKT / glycogen_synthase_kinase_3_beta / microphthalmia-associated_transcription_factor and tyrosinase-related_protein_1 / tyrosinase .
26278531	0	microphthalmia-associated_transcription_factor	106,152	tyrosinase	186,196	microphthalmia-associated transcription factor	tyrosinase	17342(Tax:10090)	22173(Tax:10090)	Gene	Gene	glycogen_synthase_kinase_3_beta|dep|START_ENTITY END_ENTITY|nsubj|glycogen_synthase_kinase_3_beta	N - -LRB- 4-bromophenethyl -RRB- _ caffeamide inhibits melanogenesis by regulating AKT / glycogen_synthase_kinase_3_beta / microphthalmia-associated_transcription_factor and tyrosinase-related_protein_1 / tyrosinase .
8995290	0	microphthalmia-associated_transcription_factor	23,69	tyrosinase	122,132	microphthalmia-associated transcription factor	tyrosinase	4286	7299	Gene	Gene	analysis|nmod|START_ENTITY analysis|nmod|transcription transcription|nmod|genes genes|amod|END_ENTITY	Functional analysis of microphthalmia-associated_transcription_factor in pigment cell-specific transcription of the human tyrosinase family genes .
17266927	0	microphthalmia_transcription_factor	8,43	Mitf	45,49	microphthalmia transcription factor	Mitf	17342(Tax:10090)	17342(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of microphthalmia_transcription_factor -LRB- Mitf -RRB- in melanoma differentiation .
18028952	0	microphthalmia_transcription_factor	13,48	Mitf	50,54	microphthalmia transcription factor	Mitf	4286	4286	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of microphthalmia_transcription_factor -LRB- Mitf -RRB- by forskolin and stimulation of melanin release in UISO-Mel-6 cells .
14984931	0	microsomal_epoxide_hydrolase	20,48	EPHX1	55,60	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- expression by the transcription factor GATA-4 .
15150264	0	microsomal_epoxide_hydrolase	87,115	EPHX1	122,127	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	CCAAT/enhancer-binding _ protein_alpha -LRB- C/EBPalpha -RRB- activates transcription of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- through the interaction with DNA-bound NF-Y .
15465926	0	microsomal_epoxide_hydrolase	81,109	EPHX1	116,121	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Alternative promoters determine tissue-specific expression profiles of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- .
15716486	0	microsomal_epoxide_hydrolase	111,139	EPHX1	146,151	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variability in human sensitivity to 1,3-butadiene : influence of polymorphisms in the 5 ' - flanking region of the microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- .
23714182	0	microsomal_epoxide_hydrolase	27,55	EPHX1	62,67	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcription of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- is regulated by an HNF-4a / CAR/RXR/PSF complex .
24315822	0	microsomal_epoxide_hydrolase	73,101	EPHX1	103,108	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal_epoxide_hydrolase -LRB- EPHX1 -RRB- through interaction with the E1b far upstream promoter .
24704207	0	microsomal_epoxide_hydrolase	73,101	EPHX1	108,113	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- through a far upstream alternative promoter .
7835893	0	microsomal_epoxide_hydrolase	10,38	EPHX1	45,50	microsomal epoxide hydrolase	EPHX1	2052	2052	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human microsomal_epoxide_hydrolase gene -LRB- EPHX1 -RRB- : complete nucleotide sequence and structural characterization .
20682710	0	microsomal_prostaglandin-E_synthase-1	106,143	vascular_endothelial_growth_factor	144,178	microsomal prostaglandin-E synthase-1	vascular endothelial growth factor	9536	7422	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Inhibition of hypoxia_inducible_factor-1alpha by dihydroxyphenylethanol , a product from olive oil , blocks microsomal_prostaglandin-E_synthase-1 / vascular_endothelial_growth_factor expression and reduces tumor angiogenesis .
17014826	0	microsomal_prostaglandin_E_synthase_1	65,102	early_growth_response_gene_1	15,43	microsomal prostaglandin E synthase 1	early growth response gene 1	9536	1958	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Involvement of early_growth_response_gene_1 in the modulation of microsomal_prostaglandin_E_synthase_1 by epigallocatechin_gallate in A549 human pulmonary epithelial cells .
21684740	0	microsomal_triglyceride_transfer_protein	13,53	MTP	55,58	microsomal triglyceride transfer protein	MTP	4547	4547	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of microsomal_triglyceride_transfer_protein -LRB- MTP -RRB- inhibitors with potential for decreased active metabolite load compared to dirlotapide .
9831631	0	microsomal_triglyceride_transfer_protein	59,99	MTP	101,104	microsomal triglyceride transfer protein	MTP	4547	4547	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of two polymorphisms in the promoter of the microsomal_triglyceride_transfer_protein -LRB- MTP -RRB- gene : lack of association with lipoprotein profiles .
17854051	0	microsomal_triglyceride_transfer_protein	48,88	MTTP	90,94	microsomal triglyceride transfer protein	MTTP	4547	4547	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional analysis of promoter variants in the microsomal_triglyceride_transfer_protein -LRB- MTTP -RRB- gene .
18697801	0	microsomal_triglyceride_transfer_protein	67,107	MTTP	109,113	microsomal triglyceride transfer protein	MTTP	4547	4547	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hepatocyte nuclear factor 1 binding element within the promoter of microsomal_triglyceride_transfer_protein -LRB- MTTP -RRB- gene is crucial for MTTP basal expression and insulin responsiveness .
10455139	0	microsomal_triglyceride_transfer_protein	63,103	Sterol_regulatory_element-binding_protein	0,41	microsomal triglyceride transfer protein	Sterol regulatory element-binding protein	4547	7555	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Sterol_regulatory_element-binding_protein negatively regulates microsomal_triglyceride_transfer_protein gene transcription .
10906284	0	microtubule-associated_protein	11,41	MAP	43,46	microtubule-associated protein	MAP	54141(Tax:10090)	54141(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of microtubule-associated_protein -LRB- MAP -RRB- expression on methylmercury-induced microtubule disassembly .
19912782	0	microtubule-associated_protein	15,45	MAP1B	47,52	microtubule-associated protein	MAP1B	51115	4131	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of microtubule-associated_protein -LRB- MAP1B -RRB- with growing axons in cultured hippocampal neurons .
1905296	0	microtubule-associated_protein	28,58	MAP2	142,146	microtubule-associated protein	MAP2	4134	4133	Gene	Gene	contains|nsubj|START_ENTITY contains|nmod|domains domains|nmod|END_ENTITY	Non-neuronal 210 x 10 -LRB- 3 -RRB- Mr microtubule-associated_protein -LRB- MAP4 -RRB- contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau .
3121794	0	microtubule-associated_protein	16,46	MAP2	67,71	microtubule-associated protein	MAP2	51115	4133	Gene	Gene	related|nsubj|START_ENTITY related|nmod|END_ENTITY	A 70-kilodalton microtubule-associated_protein -LRB- MAP2c -RRB- , related to MAP2 .
18807071	0	microtubule-associated_protein	17,47	PTL-1	48,53	microtubule-associated protein	PTL-1	175230(Tax:6239)	175230(Tax:6239)	Gene	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	The invertebrate microtubule-associated_protein PTL-1 functions in mechanosensation and development in Caenorhabditis_elegans .
8956998	0	microtubule-associated_protein	55,85	p53	10,13	microtubule-associated protein	p53	51115	7157	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Wild-type p53 negatively regulates the expression of a microtubule-associated_protein .
12079519	0	microtubule-associated_protein-2	33,65	MAP-2	67,72	microtubule-associated protein-2	MAP-2	4133	4133	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunocytochemical expression of microtubule-associated_protein-2 -LRB- MAP-2 -RRB- in small_cell_lung_cancer cell lines with neuronal-like processes .
17229541	0	microtubule-associated_protein-2	11,43	MAP2	45,49	microtubule-associated protein-2	MAP2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Changes in microtubule-associated_protein-2 -LRB- MAP2 -RRB- expression during development and after status_epilepticus in the immature rat hippocampus .
7629894	0	microtubule-associated_protein_1A	35,68	MAP1A	70,75	microtubule-associated protein 1A	MAP1A	4130	4130	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Brain-specific expression of human microtubule-associated_protein_1A -LRB- MAP1A -RRB- gene and its assignment to human chromosome 15 .
8714690	0	microtubule-associated_protein_1A	16,49	MAP1A	51,56	microtubule-associated protein 1A	MAP1A	17754(Tax:10090)	17754(Tax:10090)	Gene	Gene	Accumulation|nmod|START_ENTITY Accumulation|appos|END_ENTITY	Accumulation of microtubule-associated_protein_1A -LRB- MAP1A -RRB- in differentiating P19 embryonal_carcinoma cells .
25788676	0	microtubule-associated_protein_1A	17,50	Map1a	52,57	microtubule-associated protein 1A	Map1a	17754(Tax:10090)	17754(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the microtubule-associated_protein_1A -LRB- Map1a -RRB- gene cause Purkinje cell degeneration .
10504342	0	microtubule-associated_protein_1B	50,83	Glycogen_synthase_kinase_3beta	0,30	microtubule-associated protein 1B	Glycogen synthase kinase 3beta	4131	2932	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Glycogen_synthase_kinase_3beta phosphorylation of microtubule-associated_protein_1B regulates the stability of microtubules in growth cones .
17658481	0	microtubule-associated_protein_1S	38,71	NR3A	18,22	microtubule-associated protein 1S	NR3A	290640(Tax:10116)	191573(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The NMDAR subunit NR3A interacts with microtubule-associated_protein_1S in the brain .
8812494	0	microtubule-associated_protein_1a	6,39	MAP1A	41,46	microtubule-associated protein 1a	MAP1A	4130	4130	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human microtubule-associated_protein_1a -LRB- MAP1A -RRB- gene : genomic organization , cDNA sequence , and developmental - and tissue-specific expression .
8383965	0	microtubule-associated_protein_2	72,104	MAP	106,109	microtubule-associated protein 2	MAP	4133	4133	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated_protein_2 -LRB- MAP -RRB- kinase and a MAP kinase kinase in polymorphonuclear leucocytes .
1484385	0	microtubule-associated_protein_2	12,44	MAP-2	46,51	microtubule-associated protein 2	MAP-2	4133	4133	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of microtubule-associated_protein_2 -LRB- MAP-2 -RRB- in neuronal growth , plasticity , and degeneration .
7566447	0	microtubule-associated_protein_2	23,55	MAP-2	57,62	microtubule-associated protein 2	MAP-2	4133	4133	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abnormal expression of microtubule-associated_protein_2 -LRB- MAP-2 -RRB- in neocortex in Rett_syndrome .
2484443	0	microtubule-associated_protein_2	14,46	MAP2	48,52	microtubule-associated protein 2	MAP2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Regulation of microtubule-associated_protein_2 -LRB- MAP2 -RRB- mRNA expression during rat brain development .
3512042	0	microtubule-associated_protein_2	31,63	MAP2	65,69	microtubule-associated protein 2	MAP2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and distribution of microtubule-associated_protein_2 -LRB- MAP2 -RRB- in neuroblastoma and primary neuronal cells .
8965322	0	microtubule-associated_protein_2	11,43	MAP2	45,49	microtubule-associated protein 2	MAP2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Diminished microtubule-associated_protein_2 -LRB- MAP2 -RRB- immunoreactivity following cortical impact_brain_injury .
6343400	0	microtubule-associated_protein_2	15,47	MAP_2	49,54	microtubule-associated protein 2	MAP 2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of microtubule-associated_protein_2 -LRB- MAP_2 -RRB- with microtubules and intermediate filaments in cultured brain cells .
16804917	0	microtubule-associated_protein_4	41,73	MAP4	75,79	microtubule-associated protein 4	MAP4	4134	4134	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel fusion of the MALT1 gene and the microtubule-associated_protein_4 -LRB- MAP4 -RRB- gene occurs in diffuse large B-cell_lymphoma .
1517758	0	microtubule-associated_protein_5	34,66	MAP5	68,72	microtubule-associated protein 5	MAP5	4131	4131	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of microtubule-associated_protein_5 -LRB- MAP5 -RRB- in glial cells in multiple_system_atrophy .
9440798	0	microtubule-associated_protein_5	29,61	MAP5	63,67	microtubule-associated protein 5	MAP5	4131	4131	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical study of microtubule-associated_protein_5 -LRB- MAP5 -RRB- expression in the developing human brain .
9533556	0	microtubule-associated_protein_5	24,56	MAP5	58,62	microtubule-associated protein 5	MAP5	4131	4131	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of microtubule-associated_protein_5 -LRB- MAP5 -RRB- in the molecular layer of cerebellum in preterm infants with olivocerebellar_lesions .
11311121	0	microtubule-associated_protein_tau	98,132	DYRK	163,167	microtubule-associated protein tau	DYRK	4137	1859	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated_protein_tau at Thr212 : potential role for DYRK as a glycogen synthase kinase 3-priming kinase .
18636984	0	microtubule-associated_protein_tau	41,75	Histone_deacetylase_6	0,21	microtubule-associated protein tau	Histone deacetylase 6	4137	10013	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Histone_deacetylase_6 interacts with the microtubule-associated_protein_tau .
25353516	0	microtubule-associated_protein_tau	14,48	KIF1A	93,98	microtubule-associated protein tau	KIF1A	4137	547	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of the microtubule-associated_protein_tau on dynamics of single-headed motor proteins KIF1A .
19558713	0	microtubule-associated_protein_tau	28,62	MAPT	64,68	microtubule-associated protein tau	MAPT	4137	4137	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of the H1 haplotype of microtubule-associated_protein_tau -LRB- MAPT -RRB- gene in Greek patients with Parkinson 's _ disease .
20579400	0	microtubule-associated_protein_tau	33,67	MAPT	69,73	microtubule-associated protein tau	MAPT	4137	4137	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The estrogen_receptor influences microtubule-associated_protein_tau -LRB- MAPT -RRB- expression and the selective estrogen_receptor inhibitor fulvestrant downregulates MAPT and increases the sensitivity to taxane in breast_cancer cells .
3027087	0	microtubule-associated_proteins_1_and_2	57,96	Plectin	0,7	microtubule-associated proteins 1 and 2	Plectin	4133	5339	Gene	Gene	binding|nmod|START_ENTITY binding|nsubj|END_ENTITY	Plectin and IFAP-300K are homologous proteins binding to microtubule-associated_proteins_1_and_2 and to the 240-kilodalton subunit of spectrin .
16815997	0	microtubule_actin_cross-linking_factor_1	12,52	MACF1	54,59	microtubule actin cross-linking factor 1	MACF1	11426(Tax:10090)	11426(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of microtubule_actin_cross-linking_factor_1 -LRB- MACF1 -RRB- in the Wnt signaling pathway .
23131551	0	microtubule_associated_protein	73,103	Ribosomal_protein_S3	0,20	microtubule associated protein	Ribosomal protein S3	51115	6188	Gene	Gene	localizes|nmod|START_ENTITY localizes|nsubj|END_ENTITY	Ribosomal_protein_S3 localizes on the mitotic spindle and functions as a microtubule_associated_protein in mitosis .
2026175	0	microtubule_associated_protein_2	14,46	MAP2	48,52	microtubule associated protein 2	MAP2	25595(Tax:10116)	25595(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of microtubule_associated_protein_2 -LRB- MAP2 -RRB- expression by nerve_growth_factor in PC12 cells .
2026175	0	microtubule_associated_protein_2	14,46	nerve_growth_factor	68,87	microtubule associated protein 2	nerve growth factor	25595(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of microtubule_associated_protein_2 -LRB- MAP2 -RRB- expression by nerve_growth_factor in PC12 cells .
8003007	0	microtubule_associated_protein_tau	27,61	thrombin	65,73	microtubule associated protein tau	thrombin	4137	2147	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Proteolytic degradation of microtubule_associated_protein_tau by thrombin .
10772929	0	midkine	51,58	LDL_receptor-related_protein	0,28	midkine	LDL receptor-related protein	17242(Tax:10090)	16971(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	LDL_receptor-related_protein as a component of the midkine receptor .
10096022	0	midkine	18,25	Mdk	32,35	midkine	Mdk	17242(Tax:10090)	4192	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of the midkine gene -LRB- Mdk -RRB- resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour .
25519047	0	midkine	48,55	Ptprz1	74,80	midkine	Ptprz1	81517(Tax:10116)	25613(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the heparin-binding growth factor midkine and its receptor , Ptprz1 , in adult rat pituitary .
25428991	0	midkine	111,118	specificity_protein_1	23,44	midkine	specificity protein 1	4192	6667	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Transcriptional factor specificity_protein_1 -LRB- SP1 -RRB- promotes the proliferation of glioma cells by up-regulating midkine -LRB- MDK -RRB- .
25981737	0	midline-1	56,65	TNF-related_apoptosis-inducing_ligand	0,37	midline-1	TNF-related apoptosis-inducing ligand	17318(Tax:10090)	22035(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TNF-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- regulates midline-1 , thymic_stromal_lymphopoietin , inflammation , and remodeling in experimental eosinophilic_esophagitis .
12688353	0	mig	55,58	CXCR3	33,38	mig	CXCR3	4283	2833	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of chemokine receptor CXCR3 and its ligand , mig , in gastric and thyroid marginal zone_lymphomas .
22556421	0	migfilin	56,64	filamin-binding_LIM_protein_1	17,46	migfilin	filamin-binding LIM protein 1	74202(Tax:10090)	74202(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Critical role of filamin-binding_LIM_protein_1 -LRB- FBLP-1 -RRB- / migfilin in regulation of bone remodeling .
25873164	0	migration_and_invasion_inhibitory_protein	53,94	MIIP	96,100	migration and invasion inhibitory protein	MIIP	60672	60672	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Altered expression and loss of heterozygosity of the migration_and_invasion_inhibitory_protein -LRB- MIIP -RRB- gene in breast_cancer .
25873164	0	migration_and_invasion_inhibitory_protein	53,94	MIIP	96,100	migration and invasion inhibitory protein	MIIP	60672	60672	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Altered expression and loss of heterozygosity of the migration_and_invasion_inhibitory_protein -LRB- MIIP -RRB- gene in breast_cancer .
21485220	0	migration_inhibition_factor	26,53	MIF	55,58	migration inhibition factor	MIF	4282	4282	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of macrophage migration_inhibition_factor -LRB- MIF -RRB- in serum of patients with prostate_cancer and its clinical significance -RSB- .
6458429	0	migration_inhibition_factor	14,41	MIF	43,46	migration inhibition factor	MIF	4282	4282	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of migration_inhibition_factor -LRB- MIF -RRB- by purified human T cell subpopulations .
10086852	0	migration_inhibition_factor	52,79	interferon-gamma	20,36	migration inhibition factor	interferon-gamma	4282	3458	Gene	Gene	START_ENTITY|nsubj|release release|nmod|END_ENTITY	In vitro release of interferon-gamma and macrophage migration_inhibition_factor in drug-induced urticaria and angioedema .
1090541	0	migration_inhibitory_factor	34,61	MIF	63,66	migration inhibitory factor	MIF	4282	4282	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Intracellular localization of the migration_inhibitory_factor -LRB- MIF -RRB- in a long-term human lymphoid cell line .
370028	2	migration_inhibitory_factor	71,98	MIF	100,103	migration inhibitory factor	MIF	4282	4282	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of migration_inhibitory_factor -LRB- MIF -RRB- on macrophage microtubules .
19609608	0	migration_inhibitory_factor	54,81	nuclear_factor_kappa_B	14,36	migration inhibitory factor	nuclear factor kappa B	4282	4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of nuclear_factor_kappa_B and induction of migration_inhibitory_factor in tumors by surgical stress of laparotomy versus carbon_dioxide pneumoperitoneum : an animal experiment .
7542868	0	migration_inhibitory_factor-related_protein_8	97,142	MRP8	144,148	migration inhibitory factor-related protein 8	MRP8	6279	6279	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Increase of calcium levels in epithelial cells induces translocation of calcium-binding proteins migration_inhibitory_factor-related_protein_8 -LRB- MRP8 -RRB- and MRP14 to keratin intermediate filaments .
23526214	0	migratory_inhibition_factor	8,35	NF-E2-related_factor-2	95,117	migratory inhibition factor	NF-E2-related factor-2	17319(Tax:10090)	18024(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|amod|END_ENTITY	Role of migratory_inhibition_factor in age-related susceptibility to radiation_lung_injury via NF-E2-related_factor-2 and antioxidant regulation .
26988873	0	milk	45,49	dipeptidyl_peptidase_IV	80,103	milk	dipeptidyl peptidase IV	100532204	1803	Gene	Gene	peptides|compound|START_ENTITY peptides|nmod|END_ENTITY	Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl_peptidase_IV -LRB- DPP-IV -RRB- inhibitory activity .
3745570	0	milk	103,107	prolactin	90,99	milk	prolactin	100532204	280901(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dry period versus continuous milking on periparturient concentrations of bovine prolactin in milk from half udders .
20213738	0	milk_fat_globule-EGF_factor_8	25,54	MFG-E8	56,62	milk fat globule-EGF factor 8	MFG-E8	4240	4240	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aberrant splicing of the milk_fat_globule-EGF_factor_8 -LRB- MFG-E8 -RRB- gene in human systemic_lupus_erythematosus .
11601697	0	mim-1	8,13	P33	23,26	mim-1	P33	396471(Tax:9031)	396471(Tax:9031)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Chicken mim-1 protein , P33 , is a heterophil chemotactic factor present in Salmonella_enteritidis immune lymphokine .
8204631	0	minK	101,105	IsK	96,99	minK	IsK	398417(Tax:8355)	398417(Tax:8355)	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Secondary structure and membrane localization of synthetic segments and a truncated form of the IsK -LRB- minK -RRB- protein .
9609707	0	minK	121,125	IsK	116,119	minK	IsK	3753	3753	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Conformation and ion-channeling activity of a 27-residue peptide modeled on the single-transmembrane segment of the IsK -LRB- minK -RRB- protein .
16266404	0	minK	41,45	KCNE1	34,39	minK	KCNE1	3753	3753	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Possible association of the human KCNE1 -LRB- minK -RRB- gene and QT interval in healthy subjects : evidence from association and linkage analyses in Israeli families .
19660109	0	minK	53,57	KCNE1	44,49	minK	KCNE1	3753	3753	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Positive selection at codon 38 of the human KCNE1 -LRB- = minK -RRB- gene and sporadic absence of 38Ser-coding mRNAs in Gly38Ser heterozygotes .
25524943	0	mir-146a	59,67	mir-149	69,76	mir-146a	mir-149	406938	406941	Gene	Gene	risk|amod|START_ENTITY risk|amod|END_ENTITY	The associations of nucleotide polymorphisms in mir-196a2 , mir-146a , mir-149 with lung_cancer risk .
25524943	0	mir-149	69,76	mir-146a	59,67	mir-149	mir-146a	406941	406938	Gene	Gene	risk|amod|START_ENTITY risk|amod|END_ENTITY	The associations of nucleotide polymorphisms in mir-196a2 , mir-146a , mir-149 with lung_cancer risk .
25972084	0	mir-200a	117,125	p73	160,163	mir-200a	p73	406983	7161	Gene	Gene	upregulating|dobj|START_ENTITY upregulating|nmod|END_ENTITY	Restin suppressed epithelial-mesenchymal transition and tumor metastasis in breast_cancer cells through upregulating mir-200a / b expression via association with p73 .
25824442	0	mir29b	66,72	MMP9	34,38	mir29b	MMP9	407024	4318	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Cardiosome mediated regulation of MMP9 in diabetic heart : role of mir29b and mir455 in exercise .
25810294	0	mir33	16,21	FXR	59,62	mir33	FXR	407039	9971	Gene	Gene	Links|nsubj|START_ENTITY Links|dobj|END_ENTITY	SREBF2-Embedded mir33 Links the Nuclear Bile Acid Receptor FXR to Cholesterol and Lipoprotein Metabolism .
24285545	0	mitochondria-associated_endoplasmic_reticulum_membrane	87,141	MAM	143,146	mitochondria-associated endoplasmic reticulum membrane	MAM	6445	6445	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulation of mitochondrial_antiviral_signaling -LRB- MAVS -RRB- expression and signaling by the mitochondria-associated_endoplasmic_reticulum_membrane -LRB- MAM -RRB- protein Gp78 .
22045338	0	mitochondria-associated_membrane	45,77	TMX	14,17	mitochondria-associated membrane	TMX	6445	81542	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Palmitoylated TMX and calnexin target to the mitochondria-associated_membrane .
12325027	0	mitochondrial_12S_RNA	72,93	MTRNR1	95,101	mitochondrial 12S RNA	MTRNR1	4549	4549	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Pyrosequencing for detection of mutations in the connexin_26 -LRB- GJB2 -RRB- and mitochondrial_12S_RNA -LRB- MTRNR1 -RRB- genes associated with hereditary_hearing_loss .
23916463	0	mitochondrial_DNA_helicase	63,89	DREF	26,30	mitochondrial DNA helicase	DREF	34307(Tax:7227)	34328(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Drosophila nuclear factor DREF regulates the expression of the mitochondrial_DNA_helicase and mitochondrial_transcription_factor_B2 but not the mitochondrial_translation_factor_B1 .
9630632	0	mitochondrial_aconitase	30,53	ACO2	60,64	mitochondrial aconitase	ACO2	50	50	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the human mitochondrial_aconitase gene -LRB- ACO2 -RRB- .
26254233	0	mitochondrial_aldehyde_dehydrogenase	14,50	ALDH2	52,57	mitochondrial aldehyde dehydrogenase	ALDH2	29539(Tax:10116)	29539(Tax:10116)	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	The impact of mitochondrial_aldehyde_dehydrogenase -LRB- ALDH2 -RRB- activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression .
15900217	0	mitochondrial_aldehyde_dehydrogenase	21,57	Aldh2	64,69	mitochondrial aldehyde dehydrogenase	Aldh2	29539(Tax:10116)	29539(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the mitochondrial_aldehyde_dehydrogenase gene -LRB- Aldh2 -RRB- determine peak blood acetaldehyde levels and voluntary_ethanol_consumption in rats .
24285545	0	mitochondrial_antiviral_signaling	14,47	MAVS	49,53	mitochondrial antiviral signaling	MAVS	57506	57506	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Regulation of mitochondrial_antiviral_signaling -LRB- MAVS -RRB- expression and signaling by the mitochondria-associated_endoplasmic_reticulum_membrane -LRB- MAM -RRB- protein Gp78 .
19690333	0	mitochondrial_antiviral_signaling	21,54	Mitofusin_2	0,11	mitochondrial antiviral signaling	Mitofusin 2	57506	9927	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Mitofusin_2 inhibits mitochondrial_antiviral_signaling .
20977429	0	mitochondrial_aspartate_aminotransferase	53,93	kynurenine_aminotransferase-IV	114,144	mitochondrial aspartate aminotransferase	kynurenine aminotransferase-IV	14719(Tax:10090)	14719(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biochemical and structural characterization of mouse mitochondrial_aspartate_aminotransferase , a newly identified kynurenine_aminotransferase-IV .
24952951	0	mitochondrial_aspartate_aminotransferase	53,93	kynurenine_aminotransferase-IV	114,144	mitochondrial aspartate aminotransferase	kynurenine aminotransferase-IV	14719(Tax:10090)	14719(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biochemical and structural characterization of mouse mitochondrial_aspartate_aminotransferase , a newly identified kynurenine_aminotransferase-IV .
23246404	0	mitochondrial_calcium_uniporter	22,53	miR-25	72,78	mitochondrial calcium uniporter	miR-25	90550	407014	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of the mitochondrial_calcium_uniporter by cancer-related miR-25 .
8634143	0	mitochondrial_capsule_selenoprotein	61,96	MCS	103,106	mitochondrial capsule selenoprotein	MCS	24899(Tax:10116)	24899(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning , expression , and chromosomal localization of the rat mitochondrial_capsule_selenoprotein gene -LRB- MCS -RRB- : the reading frame does not contain potential UGA selenocysteine codons .
8833144	0	mitochondrial_capsule_selenoprotein	65,100	MCSP	107,111	mitochondrial capsule selenoprotein	MCSP	4184	4184	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation , expression , and chromosomal localization of the human mitochondrial_capsule_selenoprotein gene -LRB- MCSP -RRB- .
26692143	0	mitochondrial_carrier_homolog_1	66,97	MTCH_1	99,105	mitochondrial carrier homolog 1	MTCH 1	23787	23787	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Early_growth_response_1 -LRB- EGR-1 -RRB- is a transcriptional regulator of mitochondrial_carrier_homolog_1 -LRB- MTCH_1 -RRB- / presenilin_1-associated protein -LRB- PSAP -RRB- .
26692143	0	mitochondrial_carrier_homolog_1	66,97	PSAP	140,144	mitochondrial carrier homolog 1	PSAP	23787	5660	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Early_growth_response_1 -LRB- EGR-1 -RRB- is a transcriptional regulator of mitochondrial_carrier_homolog_1 -LRB- MTCH_1 -RRB- / presenilin_1-associated protein -LRB- PSAP -RRB- .
22416135	0	mitochondrial_carrier_homologue_2	89,122	MTCH2	124,129	mitochondrial carrier homologue 2	MTCH2	23788	23788	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Molecular basis of the interaction between proapoptotic truncated BID -LRB- tBID -RRB- protein and mitochondrial_carrier_homologue_2 -LRB- MTCH2 -RRB- protein : key players in mitochondrial death pathway .
15498114	0	mitochondrial_ceramidase	0,24	Bcl-2	53,58	mitochondrial ceramidase	Bcl-2	56624	596	Gene	Gene	up-regulates|amod|START_ENTITY END_ENTITY|nsubj|up-regulates	mitochondrial_ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells , probably through its metabolite sphingosine-1-phosphate .
9268331	0	mitochondrial_elongation_factor_Ts	50,84	elongation_factor_Tu	109,129	mitochondrial elongation factor Ts	elongation factor Tu	10102	1915	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|END_ENTITY	Role of domains in Escherichia_coli and mammalian mitochondrial_elongation_factor_Ts in the interaction with elongation_factor_Tu .
25431021	0	mitochondrial_fission_factor	66,94	miR-27	0,6	mitochondrial fission factor	miR-27	56947	407018	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-27 regulates mitochondrial networks by directly targeting the mitochondrial_fission_factor .
23867156	0	mitochondrial_fission_factor	57,85	miR-761	0,7	mitochondrial fission factor	miR-761	56947	100313892	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-761 regulates the mitochondrial network by targeting mitochondrial_fission_factor .
20079882	0	mitochondrial_ribosomal_protein_S29	14,49	MRPS29	51,57	mitochondrial ribosomal protein S29	MRPS29	7818	7818	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of mitochondrial_ribosomal_protein_S29 -LRB- MRPS29 -RRB- expression by a 5 ' - upstream open reading frame .
23923566	0	mitochondrial_ribosomal_protein_s28	11,46	mrps28	48,54	mitochondrial ribosomal protein s28	mrps28	28957	28957	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variant of mitochondrial_ribosomal_protein_s28 -LRB- mrps28 -RRB- gene is differentially expressed in response to radiation in a cervical carcinoma derived cell line .
18675571	0	mitochondrial_ribosomal_protein_subunit_6	165,206	Mrps6	208,213	mitochondrial ribosomal protein subunit 6	Mrps6	121022(Tax:10090)	121022(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the null murine sodium/myo-inositol cotransporter 1 -LRB- Smit1 or Slc5a3 -RRB- phenotype : myo-inositol rescue is independent of expression of its cognate mitochondrial_ribosomal_protein_subunit_6 -LRB- Mrps6 -RRB- gene and of phosphatidylinositol levels in neonatal brain .
23290262	0	mitochondrial_single-stranded_binding_protein	80,125	Alkyladenine_DNA_glycosylase	0,28	mitochondrial single-stranded binding protein	Alkyladenine DNA glycosylase	6742	4350	Gene	Gene	localizes|nmod|START_ENTITY localizes|nsubj|END_ENTITY	Alkyladenine_DNA_glycosylase -LRB- AAG -RRB- localizes to mitochondria and interacts with mitochondrial_single-stranded_binding_protein -LRB- mtSSB -RRB- .
12163152	0	mitochondrial_thioesterase-1	69,97	uncoupling_protein_3	22,42	mitochondrial thioesterase-1	uncoupling protein 3	192272(Tax:10116)	25708(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|nmod|END_ENTITY	De novo expression of uncoupling_protein_3 is associated to enhanced mitochondrial_thioesterase-1 expression and fatty_acid metabolism in liver of fenofibrate-treated rats .
12839966	0	mitochondrial_transcription_factor_A	30,66	P53	0,3	mitochondrial transcription factor A	P53	7019	7157	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	P53 physically interacts with mitochondrial_transcription_factor_A and differentially regulates binding to damaged DNA .
16631115	0	mitochondrial_transcription_factor_A	139,175	PGC-1alpha	124,134	mitochondrial transcription factor A	PGC-1alpha	7019	10891	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	Impaired coactivator activity of the Gly482 variant of peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha -LRB- PGC-1alpha -RRB- on mitochondrial_transcription_factor_A -LRB- Tfam -RRB- promoter .
15464268	0	mitochondrial_transcription_factor_A	24,60	TFAM	62,66	mitochondrial transcription factor A	TFAM	7019	7019	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Possible association of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- genotype with sporadic Alzheimer_disease .
15547250	0	mitochondrial_transcription_factor_A	28,64	TFAM	66,70	mitochondrial transcription factor A	TFAM	7019	7019	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Transient overexpression of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- is sufficient to stimulate mitochondrial DNA transcription , but not sufficient to increase mtDNA copy number in cultured cells .
18636550	0	mitochondrial_transcription_factor_A	14,50	TFAM	52,56	mitochondrial transcription factor A	TFAM	397279(Tax:9823)	397279(Tax:9823)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- during porcine gametogenesis and preimplantation embryo development .
24875355	0	mitochondrial_transcription_factor_A	39,75	TFAM	77,81	mitochondrial transcription factor A	TFAM	7019	7019	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Negative transcriptional regulation of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- by nuclear TFAM .
24875355	0	mitochondrial_transcription_factor_A	39,75	TFAM	94,98	mitochondrial transcription factor A	TFAM	7019	7019	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative transcriptional regulation of mitochondrial_transcription_factor_A -LRB- TFAM -RRB- by nuclear TFAM .
15978747	0	mitochondrial_transcription_factor_A	13,49	Tfam	51,55	mitochondrial transcription factor A	Tfam	7019	7019	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Study of the mitochondrial_transcription_factor_A -LRB- Tfam -RRB- gene in the primate Presbytis cristata .
25989201	0	mitochondrial_transcription_factor_A	18,54	Tfam	56,60	mitochondrial transcription factor A	Tfam	7019	7019	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The regulation of mitochondrial_transcription_factor_A -LRB- Tfam -RRB- expression during skeletal muscle cell differentiation .
25989201	0	mitochondrial_transcription_factor_A	18,54	Tfam	56,60	mitochondrial transcription factor A	Tfam	7019	7019	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The regulation of mitochondrial_transcription_factor_A -LRB- Tfam -RRB- expression during skeletal muscle cell differentiation .
26182383	0	mitochondrial_transcription_factor_A	18,54	Tfam	56,60	mitochondrial transcription factor A	Tfam	7019	7019	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The regulation of mitochondrial_transcription_factor_A -LRB- Tfam -RRB- expression during skeletal muscle cell differentiation .
15585199	0	mitochondrial_transcription_factor_A	76,112	mtTFA	114,119	mitochondrial transcription factor A	mtTFA	83474(Tax:10116)	83474(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial_transcription_factor_A -LRB- mtTFA -RRB- expression in injured rat carotid artery .
12932832	0	mitochondrial_translation_initiation_factor_2	10,55	MTIF2	62,67	mitochondrial translation initiation factor 2	MTIF2	4528	4528	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human mitochondrial_translation_initiation_factor_2 gene -LRB- MTIF2 -RRB- : transcriptional analysis and identification of a pseudogene .
22056942	0	mitochondrial_ubiquitin_ligase_activator_of_NF-kB	39,88	MULAN	90,95	mitochondrial ubiquitin ligase activator of NF-kB	MULAN	101448023	101448023	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Cloning and expression analysis of the mitochondrial_ubiquitin_ligase_activator_of_NF-kB -LRB- MULAN -RRB- in Atlantic_salmon -LRB- Salmo_salar -RRB- .
15509649	0	mitofusin_1	14,25	OPA1	0,4	mitofusin 1	OPA1	55669	4976	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	OPA1 requires mitofusin_1 to promote mitochondrial fusion .
16762064	0	mitofusin_2	63,74	MFN2	81,85	mitofusin 2	MFN2	9927	9927	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Charcot-Marie-Tooth_neuropathy type 2A : novel mutations in the mitofusin_2 gene -LRB- MFN2 -RRB- .
20951042	0	mitofusin_2	59,70	MFN2	77,81	mitofusin 2	MFN2	567448(Tax:7955)	567448(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Developmental_defects_and_neuromuscular_alterations due to mitofusin_2 gene -LRB- MFN2 -RRB- silencing in zebrafish : a new model for Charcot-Marie-Tooth_type_2A_neuropathy .
21526202	0	mitofusin_2	32,43	MFN2	50,54	mitofusin 2	MFN2	534574(Tax:9913)	534574(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An unusual splice defect in the mitofusin_2 gene -LRB- MFN2 -RRB- is associated with degenerative_axonopathy in Tyrolean Grey cattle .
24127597	0	mitofusin_2	22,33	NLRP3	50,55	mitofusin 2	NLRP3	9927	114548	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|compound|END_ENTITY	Mitochondrial protein mitofusin_2 is required for NLRP3 inflammasome activation after RNA virus infection .
10759527	0	mitogen-activated_protein_kinase	34,66	ATMPK4	0,6	mitogen-activated protein kinase	ATMPK4	837559(Tax:3702)	828151(Tax:3702)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	ATMPK4 , an Arabidopsis homolog of mitogen-activated_protein_kinase , is activated in vitro by AtMEK1 through threonine phosphorylation .
10527417	0	mitogen-activated_protein_kinase	66,98	WCK-1	43,48	mitogen-activated protein kinase	WCK-1	543088(Tax:4565)	542829(Tax:4565)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elicitor - and A23187-induced expression of WCK-1 , a gene encoding mitogen-activated_protein_kinase in wheat .
26876787	0	mitogen-activated_protein_kinase-activated_protein_kinase_2	48,107	Erk1/2	39,45	mitogen-activated protein kinase-activated protein kinase 2	Erk1/2	9261	5595;5594	Gene	Gene	kinase|appos|START_ENTITY kinase|appos|END_ENTITY	Extracellular-signal regulated kinase -LRB- Erk1/2 -RRB- , mitogen-activated_protein_kinase-activated_protein_kinase_2 -LRB- MK2 -RRB- and tristetraprolin -LRB- TTP -RRB- comprehensively regulate injury-induced immediate early gene -LRB- IEG -RRB- response in in vitro liver organ culture .
8995217	0	mitogen-activated_protein_kinase-activated_protein_kinase_2	32,91	LSP1	0,4	mitogen-activated protein kinase-activated protein kinase 2	LSP1	9261	4046	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	LSP1 is the major substrate for mitogen-activated_protein_kinase-activated_protein_kinase_2 in human neutrophils .
22950522	0	mitogen-activated_protein_kinase-activated_protein_kinase_5	58,117	MAPKAPK5	119,127	mitogen-activated protein kinase-activated protein kinase 5	MAPKAPK5	8550	8550	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Pharmacokinetics , safety , and tolerability of GLPG0259 , a mitogen-activated_protein_kinase-activated_protein_kinase_5 -LRB- MAPKAPK5 -RRB- inhibitor , given as single and multiple doses to healthy male subjects .
24974389	0	mitogen-activated_protein_kinase_1	30,64	MAPK1	66,71	mitogen-activated protein kinase 1	MAPK1	101800319	101800319	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning of the duck mitogen-activated_protein_kinase_1 -LRB- MAPK1 -RRB- gene and the development of a quantitative real-time PCR assay to detect its expression .
10593883	0	mitogen-activated_protein_kinase_1	58,92	MEK5	25,29	mitogen-activated protein kinase 1	MEK5	5594	5607	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated_protein_kinase_1 -LRB- BMK1 -RRB- signaling pathway .
23165802	0	mitogen-activated_protein_kinase_1	12,46	extracellular_signal-regulated_kinase_5	56,95	mitogen-activated protein kinase 1	extracellular signal-regulated kinase 5	116590(Tax:10116)	114509(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of big mitogen-activated_protein_kinase_1 -LRB- BMK1 -RRB- / extracellular_signal-regulated_kinase_5 -LRB- ERK5 -RRB- in the pathogenesis and progression of atherosclerosis .
26601091	0	mitogen-activated_protein_kinase_14	86,121	brain-derived_neurotrophic_factor	22,55	mitogen-activated protein kinase 14	brain-derived neurotrophic factor	81649(Tax:10116)	24225(Tax:10116)	Gene	Gene	tumor_necrosis_factor_alpha|nummod|START_ENTITY tumor_necrosis_factor_alpha|compound|END_ENTITY	Effects of doxepin on brain-derived_neurotrophic_factor , tumor_necrosis_factor_alpha , mitogen-activated_protein_kinase_14 , and AKT1 genes expression in rat hippocampus .
22508986	0	mitogen-activated_protein_kinase_6	45,79	MAPK6	81,86	mitogen-activated protein kinase 6	MAPK6	50772(Tax:10090)	50772(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	The extracellular_signal-regulated_kinase_3 -LRB- mitogen-activated_protein_kinase_6 -LSB- MAPK6 -RSB- -RRB- - MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology .
22508986	0	mitogen-activated_protein_kinase_6	45,79	extracellular_signal-regulated_kinase_3	4,43	mitogen-activated protein kinase 6	extracellular signal-regulated kinase 3	50772(Tax:10090)	50772(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|appos|-RSB-	The extracellular_signal-regulated_kinase_3 -LRB- mitogen-activated_protein_kinase_6 -LSB- MAPK6 -RSB- -RRB- - MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology .
24706368	0	mitogen-activated_protein_kinase_kinase	40,79	MEK	81,84	mitogen-activated protein kinase kinase	MEK	5609	5609	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	MR-detectable metabolic consequences of mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- inhibition .
21453480	0	mitogen-activated_protein_kinase_kinase	123,162	extracellular_signal-regulated_kinase	169,206	mitogen-activated protein kinase kinase	extracellular signal-regulated kinase	5609	5594	Gene	Gene	systemic_sclerosis|nmod|START_ENTITY factor|nmod|systemic_sclerosis factor|dep|ERK ERK|dep|END_ENTITY	Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
22672985	0	mitogen-activated_protein_kinase_kinase	18,57	extracellular_signal-regulated_kinase	58,95	mitogen-activated protein kinase kinase	extracellular signal-regulated kinase	17242(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Activation of the mitogen-activated_protein_kinase_kinase / extracellular_signal-regulated_kinase pathway overcomes cisplatin resistance in ovarian_carcinoma cells .
25774218	0	mitogen-activated_protein_kinase_kinase	135,174	extracellular_signal-regulated_kinase	181,218	mitogen-activated protein kinase kinase	extracellular signal-regulated kinase	5609	5594	Gene	Gene	systemic_sclerosis|nmod|START_ENTITY factor|nmod|systemic_sclerosis factor|dep|ERK ERK|dep|END_ENTITY	Erratum to : Thrombospondin_1 is a key mediator of transforming growth factor b-mediated cell contractility in systemic_sclerosis via a mitogen-activated_protein_kinase_kinase -LRB- MEK -RRB- / extracellular_signal-regulated_kinase -LRB- ERK -RRB- - dependent mechanism .
17197157	0	mitogen-activated_protein_kinase_kinase-1	33,74	SMAD3	0,5	mitogen-activated protein kinase kinase-1	SMAD3	5604	4088	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	SMAD3 expression is regulated by mitogen-activated_protein_kinase_kinase-1 in epithelial and smooth muscle cells .
10465442	0	mitogen-activated_protein_kinase_kinase1	47,87	MEK1	89,93	mitogen-activated protein kinase kinase1	MEK1	170851(Tax:10116)	170851(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The topography and subcellular distribution of mitogen-activated_protein_kinase_kinase1 -LRB- MEK1 -RRB- in adult rat brain and differentiating PC12 cells .
9645686	0	mitogen-activated_protein_kinase_kinase_1	125,166	p44MAPK	203,210	mitogen-activated protein kinase kinase 1	p44MAPK	5604	5595	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Insulin induction of protein_kinase_C_alpha expression is independent of insulin_receptor Tyr1162/1163 residues and involves mitogen-activated_protein_kinase_kinase_1 and sustained activation of nuclear p44MAPK .
24819614	0	mitogen-activated_protein_kinase_kinase_1_and_2	9,56	MEK1_and_2	58,68	mitogen-activated protein kinase kinase 1 and 2	MEK1 and 2	5604;5605	5604;5605	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	U0126 , a mitogen-activated_protein_kinase_kinase_1_and_2 -LRB- MEK1_and_2 -RRB- inhibitor , selectively up-regulates main isoforms of CYP3A subfamily via a pregnane_X_receptor -LRB- PXR -RRB- in HepG2 cells .
12374793	0	mitogen-activated_protein_kinase_kinase_3	15,56	p38alpha	82,90	mitogen-activated protein kinase kinase 3	p38alpha	26397(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Requirement of mitogen-activated_protein_kinase_kinase_3 -LRB- MKK3 -RRB- for activation of p38alpha and p38delta MAPK isoforms by TGF-beta_1 in murine mesangial cells .
16805806	0	mitogen-activated_protein_kinase_kinase_4	48,89	MKK4	91,95	mitogen-activated protein kinase kinase 4	MKK4	287398(Tax:10116)	287398(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Blockade of the translocation and activation of mitogen-activated_protein_kinase_kinase_4 -LRB- MKK4 -RRB- signaling attenuates neuronal_damage during later ischemia-reperfusion .
12628002	0	mitogen-activated_protein_kinase_kinase_5	111,152	ERK5	102,106	mitogen-activated protein kinase kinase 5	ERK5	5607	5598	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	An analysis of the phosphorylation and activation of extracellular-signal-regulated_protein_kinase_5 -LRB- ERK5 -RRB- by mitogen-activated_protein_kinase_kinase_5 -LRB- MKK5 -RRB- in vitro .
12761180	0	mitogen-activated_protein_kinase_kinase_kinase	16,62	MLTK	64,68	mitogen-activated protein kinase kinase kinase	MLTK	65268	51776	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of a mitogen-activated_protein_kinase_kinase_kinase , MLTK by PKN .
17377140	0	mitogen-activated_protein_kinase_kinase_kinase_11	43,92	Cysteine-rich_secretory_protein_2	0,33	mitogen-activated protein kinase kinase kinase 11	Cysteine-rich secretory protein 2	26403(Tax:10090)	22024(Tax:10090)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Cysteine-rich_secretory_protein_2 binds to mitogen-activated_protein_kinase_kinase_kinase_11 in mouse sperm .
15731347	0	mitogen-activated_protein_kinase_kinase_kinase_4	8,56	MEKK4	58,63	mitogen-activated protein kinase kinase kinase 4	MEKK4	4216	4216	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Loss of mitogen-activated_protein_kinase_kinase_kinase_4 -LRB- MEKK4 -RRB- results in enhanced apoptosis and defective_neural_tube development .
16449643	0	mitogen-activated_protein_kinase_kinase_kinase_kinase_1	46,101	Pdcd4	25,30	mitogen-activated protein kinase kinase kinase kinase 1	Pdcd4	11184	27250	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated_protein_kinase_kinase_kinase_kinase_1 expression to suppress colon_carcinoma cell invasion .
12432554	0	mitogen-activated_protein_kinase_phosphatase-1	14,60	MKP-1	62,67	mitogen-activated protein kinase phosphatase-1	MKP-1	1843	1843	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in primary human ovarian_carcinoma .
17647144	0	mitogen-activated_protein_kinase_phosphatase-1	22,68	MKP-1	70,75	mitogen-activated protein kinase phosphatase-1	MKP-1	114856(Tax:10116)	114856(Tax:10116)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Expression changes of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in myocardium of streptozotocin-induced diabetic rats .
22333693	0	mitogen-activated_protein_kinase_phosphatase-1	4,50	MKP-1	52,57	mitogen-activated protein kinase phosphatase-1	MKP-1	1843	1843	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- gene is a potential methylation biomarker for malignancy of breast_cancer .
8900190	0	mitogen-activated_protein_kinase_phosphatase-1	63,109	MKP-1	111,116	mitogen-activated protein kinase phosphatase-1	MKP-1	1843	1843	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The selective protein_kinase_C inhibitor , Ro-31-8220 , inhibits mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- expression , induces c-Jun expression , and activates Jun_N-terminal_kinase .
15569826	0	mitogen-activated_protein_kinase_phosphatase-1	35,81	Rac1	113,117	mitogen-activated protein kinase phosphatase-1	Rac1	1843	5879	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Atrial natriuretic peptide induces mitogen-activated_protein_kinase_phosphatase-1 in human endothelial cells via Rac1 and NAD -LRB- P -RRB- H oxidase/Nox2-activation .
21084841	0	mitogen-activated_protein_kinase_phosphatase-2	33,79	ERK	91,94	mitogen-activated protein kinase phosphatase-2	ERK	1846	5594	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Post-translational regulation of mitogen-activated_protein_kinase_phosphatase-2 -LRB- MKP-2 -RRB- by ERK .
11257445	0	mitogen-activated_protein_kinase_phosphatase-2	32,78	JNK	143,146	mitogen-activated protein kinase phosphatase-2	JNK	1846	5599	Gene	Gene	activity|nmod|START_ENTITY Inactivation|nmod|activity dependent|nsubj|Inactivation dependent|nmod|translocation translocation|compound|END_ENTITY	Inactivation of JNK activity by mitogen-activated_protein_kinase_phosphatase-2 in EAhy926 endothelial cells is dependent upon agonist-specific JNK translocation to the nucleus .
11257445	0	mitogen-activated_protein_kinase_phosphatase-2	32,78	JNK	16,19	mitogen-activated protein kinase phosphatase-2	JNK	1846	5599	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inactivation of JNK activity by mitogen-activated_protein_kinase_phosphatase-2 in EAhy926 endothelial cells is dependent upon agonist-specific JNK translocation to the nucleus .
21084841	0	mitogen-activated_protein_kinase_phosphatase-2	33,79	MKP-2	81,86	mitogen-activated protein kinase phosphatase-2	MKP-2	1846	1846	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Post-translational regulation of mitogen-activated_protein_kinase_phosphatase-2 -LRB- MKP-2 -RRB- by ERK .
14551204	0	mitogen-activated_protein_kinase_phosphatase_1	93,139	ERK2	71,75	mitogen-activated protein kinase phosphatase 1	ERK2	1843	5594	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Jak2 tyrosine kinase mediates angiotensin_II-dependent inactivation of ERK2 via induction of mitogen-activated_protein_kinase_phosphatase_1 .
23533638	0	mitogen-activated_protein_kinase_phosphatase_1	64,110	MKP-1	112,117	mitogen-activated protein kinase phosphatase 1	MKP-1	1843	1843	Gene	Gene	increase|amod|START_ENTITY increase|appos|END_ENTITY	Long-acting b2-agonists increase fluticasone_propionate-induced mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP-1 -RRB- in airway_smooth_muscle cells .
26807102	0	mitogen-activated_protein_kinase_phosphatase_1	11,57	MKP1	59,63	mitogen-activated protein kinase phosphatase 1	MKP1	1843	1843	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for mitogen-activated_protein_kinase_phosphatase_1 -LRB- MKP1 -RRB- in neural cell development and survival .
11165042	0	mitogen-activated_protein_kinase_phosphatase_2	14,60	gonadotropin-releasing_hormone	64,94	mitogen-activated protein kinase phosphatase 2	gonadotropin-releasing hormone	1846	2796	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of mitogen-activated_protein_kinase_phosphatase_2 by gonadotropin-releasing_hormone .
18644985	0	mitogen-activated_protein_kinase_phosphatase_3	17,63	WT1	0,3	mitogen-activated protein kinase phosphatase 3	WT1	1848	7490	Gene	Gene	induction|nmod|START_ENTITY induction|nummod|END_ENTITY	WT1 induction of mitogen-activated_protein_kinase_phosphatase_3 represents a novel mechanism of growth suppression .
11316781	0	mitogen-regulated_protein	8,33	proliferin	34,44	mitogen-regulated protein	proliferin	17250(Tax:10090)	18811(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Mrp3 , a mitogen-regulated_protein / proliferin gene expressed in wound healing and in hair follicles .
1815996	0	mitogen-regulated_protein	32,57	proliferin	64,74	mitogen-regulated protein	proliferin	17250(Tax:10090)	18811(Tax:10090)	Gene	Gene	START_ENTITY|appos|MRP MRP|dep|END_ENTITY	Regulation of the expression of mitogen-regulated_protein -LRB- MRP ; proliferin -RRB- and cathepsin_L in cultured cells and in the murine placenta .
20878136	0	mitogen_activated_protein_kinase	108,140	MARK	142,146	mitogen activated protein kinase	MARK	4139	4139	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The antiandrogen bicalutamide activates the androgen_receptor -LRB- AR -RRB- with a mutation in codon 741 through the mitogen_activated_protein_kinase -LRB- MARK -RRB- pathway in human prostate_cancer PC3 cells .
17403137	0	mitogen_activated_protein_kinase_phosphatase-1	75,121	Jun_N-terminal_kinase	146,167	mitogen activated protein kinase phosphatase-1	Jun N-terminal kinase	114856(Tax:10116)	116554(Tax:10116)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Dexamethasone suppresses monocyte_chemoattractant_protein-1 production via mitogen_activated_protein_kinase_phosphatase-1 dependent inhibition of Jun_N-terminal_kinase and p38_mitogen-activated_protein_kinase in activated rat microglia .
22733812	0	mitogen_stress-activated_kinase_1	146,179	MSK1	181,185	mitogen stress-activated kinase 1	MSK1	9252	9252	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Dimethyl_fumarate inhibits dendritic cell maturation via nuclear factor kB -LRB- NF-kB -RRB- and extracellular_signal-regulated_kinase_1_and_2 -LRB- ERK1/2 -RRB- and mitogen_stress-activated_kinase_1 -LRB- MSK1 -RRB- signaling .
21335556	0	mitotic_arrest_deficient_2	51,77	MAD2	79,83	mitotic arrest deficient 2	MAD2	4085	4085	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Orderly inactivation of the key checkpoint protein mitotic_arrest_deficient_2 -LRB- MAD2 -RRB- during mitotic progression .
17567953	0	mitotic_centromere-associated_kinesin	42,79	Aurora_B	0,8	mitotic centromere-associated kinesin	Aurora B	11004	9212	Gene	Gene	phosphorylates|nmod|START_ENTITY phosphorylates|nsubj|END_ENTITY	Aurora_B phosphorylates multiple sites on mitotic_centromere-associated_kinesin to spatially and temporally regulate its function .
21078677	0	mitotic_centromere-associated_kinesin	20,57	PLK1	0,4	mitotic centromere-associated kinesin	PLK1	11004	5347	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	PLK1 phosphorylates mitotic_centromere-associated_kinesin and promotes its depolymerase activity .
25504441	0	mitotic_centromere-associated_kinesin	31,68	Polo-like_kinase_1	72,90	mitotic centromere-associated kinesin	Polo-like kinase 1	11004	5347	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The activity regulation of the mitotic_centromere-associated_kinesin by Polo-like_kinase_1 .
18440323	0	mitotic_centromere-associated_kinesin	24,61	Sp1	107,110	mitotic centromere-associated kinesin	Sp1	11004	6667	Gene	Gene	Regulation|nmod|START_ENTITY promoter|nsubj|Regulation promoter|nmod|END_ENTITY	Regulation of the human mitotic_centromere-associated_kinesin -LRB- MCAK -RRB- promoter by the transcription factors Sp1 and E2F1 .
20368358	0	mitotic_centromere-associated_kinesin	37,74	cyclin-dependent_kinase_1	78,103	mitotic centromere-associated kinesin	cyclin-dependent kinase 1	11004	983	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Functional and spatial regulation of mitotic_centromere-associated_kinesin by cyclin-dependent_kinase_1 .
7822426	0	mitotic_centromere-associated_kinesin	47,84	kinesin-related_protein	88,111	mitotic centromere-associated kinesin	kinesin-related protein	73804(Tax:10090)	67946(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Identification and partial characterization of mitotic_centromere-associated_kinesin , a kinesin-related_protein that associates with centromeres during mitosis .
22698524	0	mitotic_kinesin-like_protein_1	43,73	Corticotropin-releasing_hormone	0,31	mitotic kinesin-like protein 1	Corticotropin-releasing hormone	9493	1392	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone stimulates mitotic_kinesin-like_protein_1 expression via a PLC/PKC-dependent signaling pathway in hippocampal neurons .
15923109	0	mixed-lineage_kinase	14,34	MLK	36,39	mixed-lineage kinase	MLK	9175	9175	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of mixed-lineage_kinase -LRB- MLK -RRB- activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells .
15857405	0	mixed-lineage_kinase_3	101,123	Akt1	151,155	mixed-lineage kinase 3	Akt1	309168(Tax:10116)	24185(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Neuroprotective effects of preconditioning ischaemia on ischaemic_brain_injury through inhibition of mixed-lineage_kinase_3 via NMDA receptor-mediated Akt1 activation .
12458207	0	mixed_lineage_kinase_3	23,45	AKT	66,69	mixed lineage kinase 3	AKT	4296	207	Gene	Gene	regulation|nmod|START_ENTITY regulation|parataxis|leads leads|nsubj|END_ENTITY	Negative regulation of mixed_lineage_kinase_3 by protein_kinase_B / AKT leads to cell survival .
15467451	0	mixed_lineage_kinase_3	17,39	B-Raf	50,55	mixed lineage kinase 3	B-Raf	4296	673	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	A novel role for mixed_lineage_kinase_3 -LRB- MLK3 -RRB- in B-Raf activation and cell proliferation .
15467451	0	mixed_lineage_kinase_3	17,39	MLK3	41,45	mixed lineage kinase 3	MLK3	4296	4296	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for mixed_lineage_kinase_3 -LRB- MLK3 -RRB- in B-Raf activation and cell proliferation .
19586614	0	mixed_lineage_kinase_3	31,53	TRAF2	63,68	mixed lineage kinase 3	TRAF2	4296	7186	Gene	Gene	activation|nmod|START_ENTITY requires|nsubj|activation requires|dobj|END_ENTITY	Cytokine-induced activation of mixed_lineage_kinase_3 requires TRAF2 and TRAF6 .
12458207	0	mixed_lineage_kinase_3	23,45	protein_kinase_B	49,65	mixed lineage kinase 3	protein kinase B	4296	2185	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of mixed_lineage_kinase_3 by protein_kinase_B / AKT leads to cell survival .
21896721	0	mixed_lineage_leukemia_1	25,49	MLL	51,54	mixed lineage leukemia 1	MLL	4297	4297	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Function of leukemogenic mixed_lineage_leukemia_1 -LRB- MLL -RRB- fusion proteins through distinct partner protein complexes .
24831003	0	mixed_lineage_leukemia_1	18,42	MLL1	43,47	mixed lineage leukemia 1	MLL1	4297	4297	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification of mixed_lineage_leukemia_1 -LRB- MLL1 -RRB- protein as a coactivator of heat_shock_factor_1 -LRB- HSF1 -RRB- protein in response to heat_shock_protein_90 -LRB- HSP90 -RRB- inhibition .
24753318	0	mixed_lineage_leukemia_protein	50,80	c-Myb	127,132	mixed lineage leukemia protein	c-Myb	4297	4602	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	The mechanism of binding of the KIX domain to the mixed_lineage_leukemia_protein and its allosteric role in the recognition of c-Myb .
25598203	0	mkp-1	56,61	ERK	62,65	mkp-1	ERK	114856(Tax:10116)	24338(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Exposure to 900MHz electromagnetic fields activates the mkp-1 / ERK pathway and causes blood-brain barrier damage and cognitive_impairment in rats .
18344456	0	mkp3	26,30	dusp6	19,24	mkp3	dusp6	67603(Tax:10090)	67603(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the dusp6 -LRB- mkp3 -RRB- gene with mouse brain weight and forebrain structure .
15199178	5	mlh1	712,716	msh6	775,779	MLH3	mlh2	855939(Tax:4932)	850722(Tax:4932)	Gene	Gene	strains|amod|START_ENTITY greater|nmod|strains greater|nmod|strains strains|amod|END_ENTITY	In mlh1 Delta strains , heteroduplex rejection was greater than in msh6 Delta strains but less than in wild type .
18508862	0	mls-2	0,5	hlh-17	42,48	mls-2	hlh-17	180751(Tax:6239)	185460(Tax:6239)	Gene	Gene	development|compound|START_ENTITY development|amod|END_ENTITY	mls-2 and vab-3 Control glia development , hlh-17 / Olig expression and glia-dependent neurite extension in C. _ elegans .
23224948	0	mmp-9	115,120	TNF-a	125,130	mmp-9	TNF-a	4318	7124	Gene	Gene	matrix_metalloproteinase_9|dep|START_ENTITY region|nmod|matrix_metalloproteinase_9 Identifying|nmod|region Identifying|nmod|induction induction|amod|END_ENTITY	Identifying the regulative role of NF-kB binding sites within promoter region of human matrix_metalloproteinase_9 -LRB- mmp-9 -RRB- by TNF-a induction .
9878069	0	mnk1	67,71	eukaryotic_translation_initiation_factor_4G	6,49	mnk1	eukaryotic translation initiation factor 4G	8569	1981	Gene	Gene	recruits|xcomp|START_ENTITY recruits|nsubj|END_ENTITY	Human eukaryotic_translation_initiation_factor_4G -LRB- eIF4G -RRB- recruits mnk1 to phosphorylate eIF4E .
26472045	0	mnx	56,59	irx1b	83,88	mnx	irx1b	3892	114430(Tax:7955)	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	Pronephric tubule morphogenesis in zebrafish depends on mnx mediated repression of irx1b within the intermediate mesoderm .
10666030	0	mob-1	15,20	CCK	0,3	mob-1	CCK	353229(Tax:10116)	25298(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	CCK stimulates mob-1 expression and NF-kappaB activation via protein kinase C and intracellular Ca -LRB- 2 + -RRB- .
7982564	0	mod_1	76,81	sin_1	0,5	mod 1	sin 1	815152(Tax:3702)	839574(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	sin_1 , a mutation affecting female fertility in Arabidopsis , interacts with mod_1 , its recessive modifier .
11728332	0	moesin	129,135	CD43	13,17	moesin	CD43	4478	6693	Gene	Gene	relocation|nmod|START_ENTITY mediated|nmod|relocation mediated|nsubjpass|Exclusion Exclusion|nmod|END_ENTITY	Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin .
9616160	0	moesin	20,26	CD43	0,4	moesin	CD43	4478	6693	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts .
15149851	0	moesin	29,35	ERM	8,11	moesin	ERM	4478	326152(Tax:7227)	Gene	Gene	proteins|appos|START_ENTITY proteins|compound|END_ENTITY	Nuclear ERM -LRB- ezrin , radixin , moesin -RRB- proteins : regulation by cell density and nuclear import .
19592131	0	moesin	68,74	ERM	55,58	moesin	ERM	31816(Tax:7227)	326152(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Live imaging reveals that the Drosophila actin-binding ERM protein , moesin , co-localizes with the mitotic spindle .
8227193	0	moesin	93,99	Ezrin	0,5	moesin	Ezrin	4478	7430	Gene	Gene	found|nsubjpass|START_ENTITY concentrated|advcl|found concentrated|nsubj|END_ENTITY	Ezrin is concentrated in the apical microvilli of a wide variety of epithelial cells whereas moesin is found primarily in endothelial cells .
24755472	0	moesin	54,60	GRK5	34,38	moesin	GRK5	4478	2869	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate_cancer .
17447891	0	moesin	21,27	LRRK2	0,5	moesin	LRRK2	81521(Tax:10116)	300160(Tax:10116)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	LRRK2 phosphorylates moesin at threonine-558 : characterization of how Parkinson 's _ disease mutants affect kinase activity .
20434426	0	moesin	109,115	LRRK2	73,78	moesin	LRRK2	4478	120892	Gene	Gene	substrate|amod|START_ENTITY using|dobj|substrate activity|acl|using kinase|dobj|activity kinase|nsubj|Development Development|nmod|assay assay|acl|measuring measuring|dobj|END_ENTITY	Development of a high-throughput AlphaScreen assay measuring full-length LRRK2 -LRB- G2019S -RRB- kinase activity using moesin protein substrate .
8125014	0	moesin	24,30	MSN	37,40	moesin	MSN	4478	4478	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the human moesin gene -LRB- MSN -RRB- to chromosome region Xq11 .2 -- > q12 .
9703963	0	moesin	20,26	Merlin	0,6	moesin	Merlin	17698(Tax:10090)	18016(Tax:10090)	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Merlin differs from moesin in binding to F-actin and in its intra - and intermolecular interactions .
12850829	0	moesin	9,15	PECAM-1	31,38	moesin	PECAM-1	4478	5175	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Platelet moesin interacts with PECAM-1 -LRB- CD31 -RRB- .
20307615	0	moesin	12,18	PI3K	54,58	moesin	PI3K	81521(Tax:10116)	298947(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY mediated|nsubjpass|phosphorylation mediated|nmod|END_ENTITY	NGF-induced moesin phosphorylation is mediated by the PI3K , Rac1 and Akt and required for neurite formation in PC12 cells .
9516463	0	moesin	42,48	Protein_kinase_C-theta	0,22	moesin	Protein kinase C-theta	4478	5588	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Protein_kinase_C-theta phosphorylation of moesin in the actin-binding sequence .
24065547	0	moesin	85,91	ROCK-2	78,84	moesin	ROCK-2	4478	9475	Gene	Gene	cascade|compound|START_ENTITY cascade|compound|END_ENTITY	Testosterone promotes vascular endothelial cell migration via upregulation of ROCK-2 / moesin cascade .
10418104	0	moesin	47,53	Src	57,60	moesin	Src	735107(Tax:8355)	380430(Tax:8355)	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Identification and characterisation of Xenopus moesin , a Src substrate in Xenopus_laevis oocytes .
12082081	0	moesin	46,52	VCAM-1	23,29	moesin	VCAM-1	4478	7412	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes .
16231158	0	moesin	65,71	ezrin	47,52	moesin	ezrin	4478	7430	Gene	Gene	analysis|acl|START_ENTITY analysis|nmod|END_ENTITY	Mutational and immunohistochemical analysis of ezrin - , radixin - , moesin -LRB- ERM -RRB- molecules in epilepsy-associated glioneuronal_lesions .
18025306	0	moesin	82,88	ezrin	56,61	moesin	ezrin	4478	7430	Gene	Gene	requires|nmod|START_ENTITY requires|nmod|removal removal|compound|END_ENTITY	Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin .
20109539	0	moesin	28,34	ezrin	14,19	moesin	ezrin	4478	7430	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream .
15634677	0	moesin	96,102	protein_kinase_A	41,57	moesin	protein kinase A	81521(Tax:10116)	25636(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Chloride conductance is required for the protein_kinase_A and Rac1-dependent phosphorylation of moesin at Thr-558 by KCl in PC12 cells .
20109539	0	moesin	28,34	radixin	20,27	moesin	radixin	4478	5962	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream .
22684071	0	molybdenum_cofactor_biosynthesis_protein_C	89,131	MoaC2	133,138	molybdenum cofactor biosynthesis protein C	MoaC2	885826(Tax:83332)	885826(Tax:83332)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Overexpression , purification , crystallization and preliminary X-ray analysis of putative molybdenum_cofactor_biosynthesis_protein_C -LRB- MoaC2 -RRB- from Mycobacterium_tuberculosis_H37Rv .
16934346	0	mono-ADP-ribosyltransferase	49,76	ART3	77,81	mono-ADP-ribosyltransferase	ART3	419	419	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene .
22869740	0	monoacylglycerol_O-acyltransferase_1	33,69	MGAT1	71,76	monoacylglycerol O-acyltransferase 1	MGAT1	68393(Tax:10090)	68393(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Nuclear receptor PPARy-regulated monoacylglycerol_O-acyltransferase_1 -LRB- MGAT1 -RRB- expression is responsible for the lipid accumulation in diet-induced hepatic_steatosis .
24633487	0	monoacylglycerol_lipase	12,35	MAGL	37,41	monoacylglycerol lipase	MAGL	11343	11343	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of monoacylglycerol_lipase -LRB- MAGL -RRB- in the cancer progress .
26490035	0	monoacylglycerol_lipase	14,37	MAGL	39,43	monoacylglycerol lipase	MAGL	23945(Tax:10090)	23945(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of monoacylglycerol_lipase -LRB- MAGL -RRB- enhances cue-induced reinstatement of nicotine-seeking behavior in mice .
16797252	0	monoamine_oxidase	43,60	MAO	62,65	monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Immobilization stress increases endogenous monoamine_oxidase -LRB- MAO -RRB- inhibitor in rat liver .
2063399	0	monoamine_oxidase	20,37	MAO	39,42	monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Gossypol effects on monoamine_oxidase -LRB- MAO -RRB- activity in several organs of term rats .
2127505	0	monoamine_oxidase	22,39	MAO	41,44	monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of various monoamine_oxidase -LRB- MAO -RRB- inhibitors on the response of blood pressure of rats and cats to tyramine .
24373881	0	monoamine_oxidase	14,31	MAO	33,36	monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of monoamine_oxidase -LRB- MAO -RRB- by b-carbolines and their interactions in live neuronal -LRB- PC12 -RRB- and liver -LRB- HuH-7 and MH1C1 -RRB- cells .
2626178	1	monoamine_oxidase	84,101	MAO	103,106	monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	I. Changes in monoamine_oxidase -LRB- MAO -RRB- activity in the cerebral cortex and cerebellum of rats after portacaval shunt -RSB- .
2873956	0	monoamine_oxidase	40,57	MAO	59,62	monoamine oxidase	MAO	100136729(Tax:8022)	100136729(Tax:8022)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The characteristics and distribution of monoamine_oxidase -LRB- MAO -RRB- activity in different tissues of the rainbow_trout , Salmo_gairdneri .
523335	0	monoamine_oxidase	21,38	MAO	40,43	monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of selective monoamine_oxidase -LRB- MAO -RRB- inhibitors on conditioned avoidance responses -LRB- CAR -RRB- of rats .
708472	0	monoamine_oxidase	27,44	MAO	46,49	monoamine oxidase	MAO	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of reserpine on the monoamine_oxidase -LRB- MAO -RRB- activity in rat liver and brain .
3131149	0	monoamine_oxidase-A	9,28	MAO-A	30,35	monoamine oxidase-A	MAO-A	17161(Tax:10090)	17161(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role for monoamine_oxidase-A -LRB- MAO-A -RRB- in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog , 2 ` Me-MPTP .
7845378	0	monoamine_oxidase-A	48,67	MAO-A	69,74	monoamine oxidase-A	MAO-A	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of aluminium -LRB- Al -RRB- on brain mitochondrial monoamine_oxidase-A -LRB- MAO-A -RRB- activity -- an in vitro kinetic study .
16192108	0	monoamine_oxidase_A	86,105	MAO-A	107,112	monoamine oxidase A	MAO-A	29253(Tax:10116)	29253(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Stereospecific oxidation of the -LRB- S -RRB- - enantiomer of RS-8359 , a selective and reversible monoamine_oxidase_A -LRB- MAO-A -RRB- inhibitor , by aldehyde oxidase .
17298646	0	monoamine_oxidase_A	4,23	MAO-A	25,30	monoamine oxidase A	MAO-A	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The monoamine_oxidase_A -LRB- MAO-A -RRB- gene , family function and maltreatment as predictors of destructive behaviour during male adolescent alcohol consumption .
10402508	0	monoamine_oxidase_A	16,35	MAOA	37,41	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of the monoamine_oxidase_A -LRB- MAOA -RRB- gene in bipolar affective_disorder by association studies , meta-analyses , and sequencing of the promoter .
17894408	0	monoamine_oxidase_A	38,57	MAOA	64,68	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Meta-study on association between the monoamine_oxidase_A gene -LRB- MAOA -RRB- and schizophrenia .
19224413	0	monoamine_oxidase_A	15,34	MAOA	36,40	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of monoamine_oxidase_A -LRB- MAOA -RRB- polymorphisms and clinical subgroups of major_depressive_disorders in the Han Chinese population .
19368859	0	monoamine_oxidase_A	24,43	MAOA	45,49	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	An association study of monoamine_oxidase_A -LRB- MAOA -RRB- gene polymorphism in methamphetamine psychosis .
21698196	0	monoamine_oxidase_A	75,94	MAOA	101,105	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic susceptibility for individual cooperation preferences : the role of monoamine_oxidase_A gene -LRB- MAOA -RRB- in the voluntary provision of public goods .
22162429	0	monoamine_oxidase_A	32,51	MAOA	53,57	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Study of a possible role of the monoamine_oxidase_A -LRB- MAOA -RRB- gene in paranoid schizophrenia among a Chinese population .
22948232	0	monoamine_oxidase_A	43,62	MAOA	64,68	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence that the methylation state of the monoamine_oxidase_A -LRB- MAOA -RRB- gene predicts brain activity of MAO_A enzyme in healthy men .
24422758	0	monoamine_oxidase_A	39,58	MAOA	60,64	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Family-based association study between monoamine_oxidase_A -LRB- MAOA -RRB- gene promoter VNTR polymorphism and Tourette 's _ syndrome in Chinese Han population .
26298506	0	monoamine_oxidase_A	100,119	MAOA	121,125	monoamine oxidase A	MAOA	4128	4128	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between variable number of tandem repeats -LRB- VNTR -RRB- polymorphism in the promoter region of monoamine_oxidase_A -LRB- MAOA -RRB- gene and susceptibility to heroin_dependence .
19883764	0	monoamine_oxidase_A	46,65	MAO_A	116,121	monoamine oxidase A	MAO A	29253(Tax:10116)	4128	Gene	Gene	expression|nmod|START_ENTITY expression|dep|comparison comparison|nmod|END_ENTITY	High-level expression and purification of rat monoamine_oxidase_A -LRB- MAO_A -RRB- in Pichia_pastoris : comparison with human MAO_A .
19661285	0	monoamine_oxidase_A	14,33	SRY	41,44	monoamine oxidase A	SRY	4128	6736	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of monoamine_oxidase_A by the SRY gene on the Y chromosome .
11133008	0	monoamine_oxidase_A	31,50	serotonin_transporter	67,88	monoamine oxidase A	serotonin transporter	4128	6532	Gene	Gene	expression|nmod|START_ENTITY expression|dep|not not|nmod|END_ENTITY	The expression and activity of monoamine_oxidase_A , but not of the serotonin_transporter , is decreased in human placenta from pre-eclamptic pregnancies .
14692725	0	monoamine_oxidase_B	14,33	MAO-B	35,40	monoamine oxidase B	MAO-B	25750(Tax:10116)	25750(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of monoamine_oxidase_B -LRB- MAO-B -RRB- by Chinese herbal medicines .
15959855	0	monoamine_oxidase_B	9,28	MAO-B	30,35	monoamine oxidase B	MAO-B	4129	4129	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Platelet monoamine_oxidase_B -LRB- MAO-B -RRB- activity and its relationship to DL-fenfluramine-induced prolactin response in healthy men .
25600407	0	monoamine_oxidase_B	57,76	MAO-B	78,83	monoamine oxidase B	MAO-B	4129	4129	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|appos|END_ENTITY	Reversible and irreversible small molecule inhibitors of monoamine_oxidase_B -LRB- MAO-B -RRB- investigated by biophysical techniques .
10091612	0	monoamine_oxidase_B	18,37	MAOB	39,43	monoamine oxidase B	MAOB	4129	4129	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variations in the monoamine_oxidase_B -LRB- MAOB -RRB- gene are associated with Parkinson 's _ disease .
24658549	0	monoamine_oxidase_B	25,44	MAOB	46,50	monoamine oxidase B	MAOB	4129	4129	Gene	Gene	relationship|nmod|START_ENTITY relationship|appos|END_ENTITY	The relationship between monoamine_oxidase_B -LRB- MAOB -RRB- A644G polymorphism and Parkinson_disease risk : a meta-analysis .
11259630	0	monoamine_oxidase_B	20,39	Sp1	48,51	monoamine oxidase B	Sp1	4129	6667	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of human monoamine_oxidase_B gene by Sp1 and Sp3 .
1906004	0	monoamine_oxidase_type_B	30,54	MAO-B	56,61	monoamine oxidase type B	MAO-B	4129	4129	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Measurement of human cerebral monoamine_oxidase_type_B -LRB- MAO-B -RRB- activity with positron emission tomography -LRB- PET -RRB- : a dose ranging study with the reversible inhibitor Ro_19-6327 .
19876643	0	monocarboxylate_transporter	49,76	MCT1	78,82	monocarboxylate transporter	MCT1	6566	6566	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Hypoxia stimulates lactate release and modulates monocarboxylate_transporter -LRB- MCT1 , MCT2 , and MCT4 -RRB- expression in human adipocytes .
22184616	0	monocarboxylate_transporter	14,41	MCT1	42,46	monocarboxylate transporter	MCT1	6566	6566	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulation of monocarboxylate_transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors .
15894023	0	monocarboxylate_transporter_1	31,60	MCT1	62,66	monocarboxylate transporter 1	MCT1	509911(Tax:9913)	509911(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and distribution of monocarboxylate_transporter_1 -LRB- MCT1 -RRB- in the gastrointestinal tract of calves .
18313333	0	monocarboxylate_transporter_1	18,47	MCT1	49,53	monocarboxylate transporter 1	MCT1	6566	6566	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the monocarboxylate_transporter_1 -LRB- MCT1 -RRB- in cells of the porcine intestine .
24166504	0	monocarboxylate_transporter_1	30,59	MCT1	61,65	monocarboxylate transporter 1	MCT1	6566	6566	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucose deprivation increases monocarboxylate_transporter_1 -LRB- MCT1 -RRB- expression and MCT1-dependent tumor cell migration .
25656974	0	monocarboxylate_transporter_1	19,48	MCT1	50,54	monocarboxylate transporter 1	MCT1	6566	6566	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Down-regulation of monocarboxylate_transporter_1 -LRB- MCT1 -RRB- gene expression in the colon of piglets is linked to bacterial protein fermentation and pro-inflammatory cytokine-mediated signalling .
12773420	0	monocarboxylate_transporter_2	45,74	MCT2	76,80	monocarboxylate transporter 2	MCT2	20503(Tax:10090)	20503(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Developmental and hormonal regulation of the monocarboxylate_transporter_2 -LRB- MCT2 -RRB- expression in the mouse germ cells .
21070787	0	monocarboxylate_transporter_4	57,86	AMP-activated_protein_kinase	0,28	monocarboxylate transporter 4	AMP-activated protein kinase	80878(Tax:10116)	78975(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	AMP-activated_protein_kinase regulates the expression of monocarboxylate_transporter_4 in skeletal muscle .
18710470	0	monocarboxylate_transporter_8	80,109	SLC16A2	111,118	monocarboxylate transporter 8	SLC16A2	6567	6567	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prevalence and functional analysis of the S107P polymorphism -LRB- rs6647476 -RRB- of the monocarboxylate_transporter_8 -LRB- SLC16A2 -RRB- gene in the male population of north-west Spain -LRB- Galicia -RRB- .
26828982	0	monocarboxylate_transporters	28,56	Angiotensin_II	0,14	monocarboxylate transporters	Angiotensin II	25027(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Angiotensin_II up-regulates monocarboxylate_transporters expression in the rat adrenal gland .
23417128	0	monocarboxylate_transporters	40,68	MCT2	70,74	monocarboxylate transporters	MCT2	614573(Tax:9913)	614573(Tax:9913)	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Expression and cellular localization of monocarboxylate_transporters -LRB- MCT2 , MCT7 , and MCT8 -RRB- along the cattle gastrointestinal tract .
10918580	0	monocyte-chemoattractant_protein-1	47,81	MCP-1	83,88	monocyte-chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Differential transcriptional regulation of the monocyte-chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene in tumorigenic and non-tumorigenic HPV 18 positive cells : the role of the chromatin structure and AP-1 composition .
11121811	0	monocyte-chemoattractant_protein-1	90,124	p38	131,134	monocyte-chemoattractant protein-1	p38	6347	1432	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant_protein-1 via a p38 mitogen-activated protein kinase mediated pathway .
7720833	0	monocyte-macrophage_colony-stimulating_factor	11,56	M-CSF	58,63	monocyte-macrophage colony-stimulating factor	M-CSF	1435	1435	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of monocyte-macrophage_colony-stimulating_factor -LRB- M-CSF -RRB- on in vitro erythropoiesis of marrow progenitor cells from patients with renal_anemia .
16705055	0	monocyte_chemoattractant_protein-1	23,57	Angiotensin_II	0,14	monocyte chemoattractant protein-1	Angiotensin II	24770(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces monocyte_chemoattractant_protein-1 expression via a nuclear factor-kappaB-dependent pathway in rat preadipocytes .
19429670	0	monocyte_chemoattractant_protein-1	40,74	Angiotensin_II	0,14	monocyte chemoattractant protein-1	Angiotensin II	6347	183	Gene	Gene	production|amod|START_ENTITY increase|nmod|production enhances|dobj|increase enhances|nsubj|END_ENTITY	Angiotensin_II enhances the increase in monocyte_chemoattractant_protein-1 production induced by tumor_necrosis_factor - -LCB- alpha -RCB- from 3T3-L1 preadipocytes .
19816747	0	monocyte_chemoattractant_protein-1	43,77	Angiotensin_II	0,14	monocyte chemoattractant protein-1	Angiotensin II	6347	183	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates the expression of monocyte_chemoattractant_protein-1 in pancreatic_cancer cells .
27069537	0	monocyte_chemoattractant_protein-1	186,220	Angiotensin_II	0,14	monocyte chemoattractant protein-1	Angiotensin II	6347	183	Gene	Gene	expression|nmod|START_ENTITY modulating|dobj|expression complicated|advcl|modulating acute_aortic_dissection|acl|complicated induces|nmod|acute_aortic_dissection induces|nsubj|END_ENTITY	Angiotensin_II induces apoptosis of human pulmonary microvascular endothelial cells in acute_aortic_dissection complicated with lung_injury patients through modulating the expression of monocyte_chemoattractant_protein-1 .
9797345	0	monocyte_chemoattractant_protein-1	23,57	Angiotensin_II	0,14	monocyte chemoattractant protein-1	Angiotensin II	24770(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces monocyte_chemoattractant_protein-1 gene expression in rat vascular smooth muscle cells .
20829510	0	monocyte_chemoattractant_protein-1	28,62	Apolipoprotein_CIII	0,19	monocyte chemoattractant protein-1	Apolipoprotein CIII	20296(Tax:10090)	11814(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Apolipoprotein_CIII induces monocyte_chemoattractant_protein-1 and interleukin_6 expression via Toll-like_receptor_2 pathway in mouse adipocytes .
12594282	0	monocyte_chemoattractant_protein-1	82,116	Bone_morphogenetic_protein-7	0,28	monocyte chemoattractant protein-1	Bone morphogenetic protein-7	6347	655	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Bone_morphogenetic_protein-7 inhibits constitutive and interleukin-1_beta-induced monocyte_chemoattractant_protein-1 expression in human mesangial cells : role for JNK/AP -1 pathway .
12734374	0	monocyte_chemoattractant_protein-1	23,57	C-C_chemokine_ligand_2	0,22	monocyte chemoattractant protein-1	C-C chemokine ligand 2	20296(Tax:10090)	20296(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	C-C_chemokine_ligand_2 / monocyte_chemoattractant_protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse .
19125409	0	monocyte_chemoattractant_protein-1	8,42	CCL2	50,54	monocyte chemoattractant protein-1	CCL2	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of monocyte_chemoattractant_protein-1 -LRB- MCP-1 / CCL2 -RRB- in migration of neural progenitor cells toward glial_tumors .
11717355	0	monocyte_chemoattractant_protein-1	72,106	CCR2	23,27	monocyte chemoattractant protein-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	microvessels|amod|START_ENTITY binding|nmod|microvessels mediates|dobj|binding mediates|nsubj|END_ENTITY	The chemokine receptor CCR2 mediates the binding and internalization of monocyte_chemoattractant_protein-1 along brain microvessels .
14662900	0	monocyte_chemoattractant_protein-1	13,47	CCR2	48,52	monocyte chemoattractant protein-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Blocking the monocyte_chemoattractant_protein-1 / CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed_death-1 ligand-1-dependent mechanism .
15059935	0	monocyte_chemoattractant_protein-1	17,51	CCR2	61,65	monocyte chemoattractant protein-1	CCR2	20296(Tax:10090)	12772(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY role|nmod|receptor END_ENTITY|nsubj|role	Critical role of monocyte_chemoattractant_protein-1 receptor CCR2 on monocytes in hypertension-induced vascular_inflammation and remodeling .
19420107	0	monocyte_chemoattractant_protein-1	4,38	CCR2	39,43	monocyte chemoattractant protein-1	CCR2	6347	729230	Gene	Gene	loop|amod|START_ENTITY loop|compound|END_ENTITY	The monocyte_chemoattractant_protein-1 / CCR2 loop , inducible by TGF-beta , increases podocyte motility and albumin permeability .
23007133	0	monocyte_chemoattractant_protein-1	4,38	CCR2	47,51	monocyte chemoattractant protein-1	CCR2	24770(Tax:10116)	60463(Tax:10116)	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	The monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- / CCR2 system is involved in peritoneal_dialysis-related epithelial-mesenchymal transition of peritoneal mesothelial cells .
23408426	0	monocyte_chemoattractant_protein-1	123,157	CCR2	41,45	monocyte chemoattractant protein-1	CCR2	6347	729230	Gene	Gene	forms|nmod|START_ENTITY enhances|nmod|forms enhances|nsubj|sulfation sulfation|nmod|END_ENTITY	Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- .
9837883	0	monocyte_chemoattractant_protein-1	10,44	CCR2B	92,97	monocyte chemoattractant protein-1	CCR2B	6347	729230	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Monomeric monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- binds and activates the MCP-1_receptor CCR2B .
23274856	0	monocyte_chemoattractant_protein-1	13,47	CTGF	0,4	monocyte chemoattractant protein-1	CTGF	6347	1490	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	CTGF induces monocyte_chemoattractant_protein-1 expression to enhance monocyte migration in human synovial fibroblasts .
16597919	0	monocyte_chemoattractant_protein-1	78,112	Calcitonin_gene-related_peptide	0,31	monocyte chemoattractant protein-1	Calcitonin gene-related peptide	6347	796	Gene	Gene	secretion|amod|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Calcitonin_gene-related_peptide inhibits interleukin-1beta-induced endogenous monocyte_chemoattractant_protein-1 secretion in type II alveolar epithelial cells .
16427785	0	monocyte_chemoattractant_protein-1	24,58	Cardiotrophin-1	0,15	monocyte chemoattractant protein-1	Cardiotrophin-1	6347	1489	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Cardiotrophin-1 induces monocyte_chemoattractant_protein-1 synthesis in human umbilical vein endothelial cells .
19501916	0	monocyte_chemoattractant_protein-1	33,67	E-selectin	80,90	monocyte chemoattractant protein-1	E-selectin	6347	6401	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Interleukin-7 is associated with monocyte_chemoattractant_protein-1 and soluble E-selectin levels in peripheral blood of newly post-menopausal women .
19125410	0	monocyte_chemoattractant_protein-1	43,77	ERK	92,95	monocyte chemoattractant protein-1	ERK	24770(Tax:10116)	24338(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Reciprocal regulation of ATPgammaS-induced monocyte_chemoattractant_protein-1 production by ERK and p38 MAP kinases in rat corticostriatal slice cultures .
20384770	0	monocyte_chemoattractant_protein-1	92,126	ERK	24,27	monocyte chemoattractant protein-1	ERK	24770(Tax:10116)	24338(Tax:10116)	Gene	Gene	production|amod|START_ENTITY critical|nmod|production critical|nsubj|activation activation|nmod|END_ENTITY	Sustained activation of ERK signaling in astrocytes is critical for neuronal_injury-induced monocyte_chemoattractant_protein-1 production in rat corticostriatal slice cultures .
16792687	0	monocyte_chemoattractant_protein-1	41,75	IL-13	23,28	monocyte chemoattractant protein-1	IL-13	6347	3596	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Interleukin -LRB- IL -RRB- -4 and IL-13 up-regulate monocyte_chemoattractant_protein-1 expression in human bronchial epithelial cells : involvement of p38_mitogen-activated_protein_kinase , extracellular_signal-regulated_kinase 1/2 and Janus_kinase-2 but not c-Jun_NH2-terminal_kinase 1/2 signalling pathways .
8752938	0	monocyte_chemoattractant_protein-1	154,188	IL-2	119,123	monocyte chemoattractant protein-1	IL-2	6347	3558	Gene	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	Human fibroblasts express functional IL-2 receptors formed by the IL-2R_alpha - and beta-chain subunits : association of IL-2 binding with secretion of the monocyte_chemoattractant_protein-1 .
12734374	0	monocyte_chemoattractant_protein-1	23,57	IL-4	85,89	monocyte chemoattractant protein-1	IL-4	20296(Tax:10090)	16189(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|compound|END_ENTITY	C-C_chemokine_ligand_2 / monocyte_chemoattractant_protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse .
12488502	0	monocyte_chemoattractant_protein-1	37,71	Interleukin-10	0,14	monocyte chemoattractant protein-1	Interleukin-10	6347	3586	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-10 differently regulates monocyte_chemoattractant_protein-1 gene expression depending on the environment in a human monoblastic cell line , UG3 .
9301536	0	monocyte_chemoattractant_protein-1	35,69	Interleukin-13	0,14	monocyte chemoattractant protein-1	Interleukin-13	6347	3596	Gene	Gene	synthesis|amod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Interleukin-13 selectively induces monocyte_chemoattractant_protein-1 synthesis and secretion by human endothelial cells .
12357369	0	monocyte_chemoattractant_protein-1	22,56	Interleukin_6	0,13	monocyte chemoattractant protein-1	Interleukin 6	6347	3569	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_6 induces monocyte_chemoattractant_protein-1 expression in myeloma cells .
10378384	0	monocyte_chemoattractant_protein-1	20,54	MCP-1	56,61	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Local expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in idiopathic_inflammatory_myopathies .
10759766	0	monocyte_chemoattractant_protein-1	51,85	MCP-1	87,92	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Thromboxane_A2 -LRB- TXA2 -RRB- receptor blockade suppresses monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- expression by stimulated vascular endothelial cells .
17694504	0	monocyte_chemoattractant_protein-1	135,169	MCP-1	171,176	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Circulating advanced glycation end products -LRB- AGEs -RRB- and soluble form of receptor for AGEs -LRB- sRAGE -RRB- are independent determinants of serum monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- levels in patients with type 2 diabetes .
18230355	0	monocyte_chemoattractant_protein-1	53,87	MCP-1	89,94	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the -2518 G/A polymorphism in the monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene and myocardial_infarction in Tunisian patients .
18977211	0	monocyte_chemoattractant_protein-1	53,87	MCP-1	89,94	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the -2518 G/A polymorphism in the monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene and hypertension in Tunisian patients .
22531750	0	monocyte_chemoattractant_protein-1	22,56	MCP-1	58,63	monocyte chemoattractant protein-1	MCP-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of spinal monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in cancer-induced_bone_pain in rats .
23017229	0	monocyte_chemoattractant_protein-1	124,158	MCP-1	160,165	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Genome-wide association replicates the association of Duffy_antigen_receptor_for_chemokines -LRB- DARC -RRB- polymorphisms with serum monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- levels in Hispanic children .
23375122	0	monocyte_chemoattractant_protein-1	8,42	MCP-1	44,49	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- as an immune-diagnostic biomarker in the pathogenesis of chronic_periodontal_disease .
23930970	0	monocyte_chemoattractant_protein-1	53,87	MCP-1	89,94	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of -2518 A > G promoter polymorphism in the monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- gene with type_2_diabetes and coronary_artery_disease .
7510962	0	monocyte_chemoattractant_protein-1	29,63	MCP-1	65,70	monocyte chemoattractant protein-1	MCP-1	281043(Tax:9913)	281043(Tax:9913)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Porcine luteal cells express monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- : analysis by polymerase chain reaction and cDNA cloning .
7589574	0	monocyte_chemoattractant_protein-1	25,59	MCP-1	61,66	monocyte chemoattractant protein-1	MCP-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Synergistic induction of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- by platelet-derived growth factor and interleukin-1 .
8195247	0	monocyte_chemoattractant_protein-1	37,71	MCP-1	73,78	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Structure/activity analysis of human monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- by mutagenesis .
8230263	0	monocyte_chemoattractant_protein-1	22,56	MCP-1	58,63	monocyte chemoattractant protein-1	MCP-1	6347	6347	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Quantitative study of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in cerebrospinal fluid and cyst fluid from patients with malignant_glioma .
9227349	0	monocyte_chemoattractant_protein-1	12,46	MCP-1	48,53	monocyte chemoattractant protein-1	MCP-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- in the pathogenesis of collagen-induced arthritis in rats .
9528906	0	monocyte_chemoattractant_protein-1	22,56	MIP-1alpha	107,117	monocyte chemoattractant protein-1	MIP-1alpha	6347	6348	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Correlation of plasma monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- and monocyte inflammatory protein-1alpha -LRB- MIP-1alpha -RRB- levels with disease activity and clinical course of sarcoidosis .
25044948	0	monocyte_chemoattractant_protein-1	51,85	PPARy	101,106	monocyte chemoattractant protein-1	PPARy	6347	5468	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Docosahexaenoic_acid reduces linoleic_acid induced monocyte_chemoattractant_protein-1 expression via PPARy and nuclear factor-kB pathway in retinal pigment epithelial cells .
11316851	0	monocyte_chemoattractant_protein-1	34,68	Proteinase_3	0,12	monocyte chemoattractant protein-1	Proteinase 3	6347	5657	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Proteinase_3 enhances endothelial monocyte_chemoattractant_protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1 .
15930146	0	monocyte_chemoattractant_protein-1	21,55	TGF-beta1	0,9	monocyte chemoattractant protein-1	TGF-beta1	6347	7040	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	TGF-beta1 stimulates monocyte_chemoattractant_protein-1 expression in mesangial cells through a phosphodiesterase_isoenzyme_4-dependent process .
10479651	0	monocyte_chemoattractant_protein-1	28,62	THP-1	92,97	monocyte chemoattractant protein-1	THP-1	6347	2736	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	9-cis retinoic_acid induces monocyte_chemoattractant_protein-1 secretion in human monocytic THP-1 cells .
15136050	0	monocyte_chemoattractant_protein-1	17,51	TNF-alpha	84,93	monocyte chemoattractant protein-1	TNF-alpha	6347	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Aspirin inhibits monocyte_chemoattractant_protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells .
17346550	0	monocyte_chemoattractant_protein-1	19,53	Thrombin	0,8	monocyte chemoattractant protein-1	Thrombin	6347	2147	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Thrombin regulates monocyte_chemoattractant_protein-1 expression in human first trimester and term decidual cells .
18622025	0	monocyte_chemoattractant_protein-1	36,70	Thrombin	0,8	monocyte chemoattractant protein-1	Thrombin	24770(Tax:10116)	29251(Tax:10116)	Gene	Gene	production|acl|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Thrombin enhances the production of monocyte_chemoattractant_protein-1 and macrophage_inflammatory_protein-2 in cultured rat glomerular epithelial cells .
7641321	0	monocyte_chemoattractant_protein-1	33,67	Thrombin	0,8	monocyte chemoattractant protein-1	Thrombin	6347	2147	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	Thrombin regulates expression of monocyte_chemoattractant_protein-1 in vascular smooth muscle cells .
24371584	0	monocyte_chemoattractant_protein-1	70,104	Toll-like_receptor-2	33,53	monocyte chemoattractant protein-1	Toll-like receptor-2	6347	7097	Gene	Gene	production|amod|START_ENTITY END_ENTITY|dobj|production	Estrogen_receptor-alpha mediates Toll-like_receptor-2 agonist-induced monocyte_chemoattractant_protein-1 production in mesangial cells .
24824254	0	monocyte_chemoattractant_protein-1	22,56	Urotensin_II	0,12	monocyte chemoattractant protein-1	Urotensin II	24770(Tax:10116)	29180(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Urotensin_II promotes monocyte_chemoattractant_protein-1 expression in aortic adventitial fibroblasts of rat .
15634454	0	monocyte_chemoattractant_protein-1	14,48	angiotensin_II	88,102	monocyte chemoattractant protein-1	angiotensin II	6347	183	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	-LSB- Induction of monocyte_chemoattractant_protein-1 expression in human mesangial cells by angiotensin_II : role of c-Jun N-terminal kinase-c-Jun/activator protein-1 signal pathway -RSB- .
17303665	0	monocyte_chemoattractant_protein-1	13,47	angiotensin_II	62,76	monocyte chemoattractant protein-1	angiotensin II	20296(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of monocyte_chemoattractant_protein-1 expression by angiotensin_II in the pancreatic islets and beta-cells .
17697525	0	monocyte_chemoattractant_protein-1	110,144	angiotensin_II	16,30	monocyte chemoattractant protein-1	angiotensin II	6347	183	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression end-product|acl:relcl|induced inhibits|dobj|end-product inhibits|nsubj|Telmisartan Telmisartan|appos|blocker blocker|compound|END_ENTITY	Telmisartan , an angiotensin_II type 1 receptor blocker , inhibits advanced glycation end-product -LRB- AGE -RRB- - induced monocyte_chemoattractant_protein-1 expression in mesangial cells through downregulation of receptor for AGEs via peroxisome_proliferator-activated_receptor-gamma activation .
14684425	0	monocyte_chemoattractant_protein-1	78,112	apoptosis_signal-regulating_kinase-1	15,51	monocyte chemoattractant protein-1	apoptosis signal-regulating kinase-1	24770(Tax:10116)	365057(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Involvement|nmod|expression Involvement|nmod|END_ENTITY	Involvement of apoptosis_signal-regulating_kinase-1 on angiotensin_II-induced monocyte_chemoattractant_protein-1 expression .
9633928	0	monocyte_chemoattractant_protein-1	102,136	interleukin-8	41,54	monocyte chemoattractant protein-1	interleukin-8	6347	3576	Gene	Gene	production|dep|START_ENTITY production|nmod|END_ENTITY	Cyclic stretch upregulates production of interleukin-8 and monocyte_chemotactic_and_activating_factor / monocyte_chemoattractant_protein-1 in human endothelial cells .
18623207	0	monocyte_chemoattractant_protein-1	16,50	macrophage_inflammatory_protein-1beta	52,89	monocyte chemoattractant protein-1	macrophage inflammatory protein-1beta	6347	6351	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Increased serum monocyte_chemoattractant_protein-1 , macrophage_inflammatory_protein-1beta , and interleukin-8 concentrations in hemophagocytic_lymphohistiocytosis .
16834927	0	monocyte_chemoattractant_protein-1	43,77	p38_mitogen-activated_protein_kinase	93,129	monocyte chemoattractant protein-1	p38 mitogen-activated protein kinase	24770(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|activation activation|amod|END_ENTITY	Advanced oxidation protein products induce monocyte_chemoattractant_protein-1 expression via p38_mitogen-activated_protein_kinase activation in rat vascular smooth muscle cells .
23475608	0	monocyte_chemoattractant_protein-1	101,135	protease-activated_receptor_2	161,190	monocyte chemoattractant protein-1	protease-activated receptor 2	6347	2150	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nmod|activation activation|nmod|END_ENTITY	Thromboxane_A2_receptor-mediated release of matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- induces expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- by activation of protease-activated_receptor_2 -LRB- PAR2 -RRB- in A549 human lung_adenocarcinoma cells .
22288595	0	monocyte_chemoattractant_protein-1	57,91	protein_D	11,20	monocyte chemoattractant protein-1	protein D	6347	10202	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Surfactant protein_D inhibits lipopolysaccharide-induced monocyte_chemoattractant_protein-1 expression in human renal tubular epithelial cells : implication for tubulointerstitial fibrosis .
7957666	0	monocyte_chemoattractant_protein-1	19,53	protein_tyrosine_kinase	110,133	monocyte chemoattractant protein-1	protein tyrosine kinase	6347	2046	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Gene expression of monocyte_chemoattractant_protein-1 in human monocytes is regulated by cell density through protein_tyrosine_kinase and protein_kinase_C .
18976655	0	monocyte_chemoattractant_protein-1	55,89	thioredoxin	19,30	monocyte chemoattractant protein-1	thioredoxin	6347	7295	Gene	Gene	secretion|amod|START_ENTITY role|nmod|secretion role|nmod|END_ENTITY	Regulatory role of thioredoxin in homocysteine-induced monocyte_chemoattractant_protein-1 secretion in monocytes/macrophages .
22687405	0	monocyte_chemoattractant_protein-1	107,141	thrombin	194,202	monocyte chemoattractant protein-1	thrombin	24770(Tax:10116)	29251(Tax:10116)	Gene	Gene	stimulated|amod|START_ENTITY increase|nmod|stimulated inhibits|dobj|increase inhibits|nmod|END_ENTITY	Mizoribine suppresses proliferation of rat glomerular epithelial cells in culture and inhibits increase of monocyte_chemoattractant_protein-1 and macrophage_inflammatory_protein-2 stimulated by thrombin .
9846835	0	monocyte_chemoattractant_protein-1	24,58	transforming_growth_factor_beta	90,121	monocyte chemoattractant protein-1	transforming growth factor beta	6347	7040	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Astrocyte expression of monocyte_chemoattractant_protein-1 is differentially regulated by transforming_growth_factor_beta .
12399621	0	monocyte_chemoattractant_protein-1	91,125	tumor_necrosis_factor-alpha	32,59	monocyte chemoattractant protein-1	tumor necrosis factor-alpha	6347	7124	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Exogenous nitric_oxide inhibits tumor_necrosis_factor-alpha - or interleukin-1-beta-induced monocyte_chemoattractant_protein-1 expression in human mesangial cells .
12845752	0	monocyte_chemoattractant_protein-1	92,126	tumor_necrosis_factor-alpha	20,47	monocyte chemoattractant protein-1	tumor necrosis factor-alpha	281043(Tax:9913)	280943(Tax:9913)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induce|dobj|expression induce|nsubj|END_ENTITY	Interleukin-1_beta , tumor_necrosis_factor-alpha and lipopolysaccharide induce expression of monocyte_chemoattractant_protein-1 in calf aortic smooth muscle cells .
16436659	0	monocyte_chemoattractant_protein-1	14,48	tumor_necrosis_factor-alpha	63,90	monocyte chemoattractant protein-1	tumor necrosis factor-alpha	6347	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of monocyte_chemoattractant_protein-1 expression by tumor_necrosis_factor-alpha and interleukin-1beta in first trimester human decidual cells : implications for preeclampsia .
21544387	0	monocyte_chemoattractant_protein-1	10,44	tumor_necrosis_factor-alpha	59,86	monocyte chemoattractant protein-1	tumor necrosis factor-alpha	6347	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Increased monocyte_chemoattractant_protein-1 expression by tumor_necrosis_factor-alpha can mediate macrophage infiltration in gliomas .
8832978	0	monocyte_chemoattractant_protein-1	88,122	tumor_necrosis_factor-alpha	21,48	monocyte chemoattractant protein-1	tumor necrosis factor-alpha	6347	7124	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	Antioxidants inhibit tumor_necrosis_factor-alpha mediated stimulation of interleukin-8 , monocyte_chemoattractant_protein-1 , and collagenase expression in cultured human synovial cells .
21712071	0	monocyte_chemoattractant_protein-1	14,48	tumor_necrosis_factor_receptor_1	70,102	monocyte chemoattractant protein-1	tumor necrosis factor receptor 1	24770(Tax:10116)	25625(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of monocyte_chemoattractant_protein-1 and its induction by tumor_necrosis_factor_receptor_1 in sensory neurons in the ventral rhizotomy model of neuropathic_pain .
26591766	0	monocyte_chemoattractant_protein-1_receptor	33,76	CCR2	77,81	monocyte chemoattractant protein-1 receptor	CCR2	729230	729230	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	-LSB- Interaction of polymorphisms of monocyte_chemoattractant_protein-1_receptor CCR2 gene 190A/G , nicotinamide_adenine_dinucleotide_phosphate oxidase subunit p22phox gene C242T and cigarette smoking increases the risk of nonalcoholic_fatty_liver_disease -RSB- .
7759884	0	monocyte_chemoattractant_protein-1_receptor	116,159	Monocyte_chemoattractant_protein-3	0,34	monocyte chemoattractant protein-1 receptor	Monocyte chemoattractant protein-3	729230	6354	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|END_ENTITY	Monocyte_chemoattractant_protein-3 , but not monocyte_chemoattractant_protein-2 , is a functional ligand of the human monocyte_chemoattractant_protein-1_receptor .
7999015	0	monocyte_chemoattractant_protein-2	29,63	MCP-2	65,70	monocyte chemoattractant protein-2	MCP-2	281044(Tax:9913)	281044(Tax:9913)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Porcine luteal cells express monocyte_chemoattractant_protein-2 -LRB- MCP-2 -RRB- : analysis by cDNA cloning and northern analysis .
17824960	0	monocyte_chemoattractant_protein-4	10,44	CCL13	53,58	monocyte chemoattractant protein-4	CCL13	6357	6357	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role of monocyte_chemoattractant_protein-4 -LRB- MCP-4 -RRB- / CCL13 from chondrocytes in rheumatoid_arthritis .
10417339	0	monocyte_chemoattractant_protein_1	42,76	Fibrinogen	0,10	monocyte chemoattractant protein 1	Fibrinogen	6347	2244	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Fibrinogen up-regulates the expression of monocyte_chemoattractant_protein_1 in human saphenous vein endothelial cells .
16407046	0	monocyte_chemoattractant_protein_1	58,92	Interleukin-4_and_13	0,20	monocyte chemoattractant protein 1	Interleukin-4 and 13	6347	3565;3596	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induce|dobj|expression induce|nsubj|END_ENTITY	Interleukin-4_and_13 induce the expression and release of monocyte_chemoattractant_protein_1 , interleukin-6 and stem_cell_factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha .
26429331	0	monocyte_chemoattractant_protein_1	15,49	MCP-1	51,56	monocyte chemoattractant protein 1	MCP-1	6347	6347	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of monocyte_chemoattractant_protein_1 -LRB- MCP-1 -RRB- gene polymorphism with lupus_nephritis in Egyptian patients .
16407046	0	monocyte_chemoattractant_protein_1	58,92	interleukin-6	94,107	monocyte chemoattractant protein 1	interleukin-6	6347	3569	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Interleukin-4_and_13 induce the expression and release of monocyte_chemoattractant_protein_1 , interleukin-6 and stem_cell_factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha .
7963719	0	monocyte_chemoattractant_protein_1	67,101	monocyte_chemotactic_and_activating_factor	24,66	monocyte chemoattractant protein 1	monocyte chemotactic and activating factor	6347	6347	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Selective expression of monocyte_chemotactic_and_activating_factor / monocyte_chemoattractant_protein_1 in human blood monocytes by Mycobacterium_tuberculosis .
19565503	0	monocyte_chemoattractant_protein_1	36,70	osteopontin	8,19	monocyte chemoattractant protein 1	osteopontin	6347	6696	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|nmod|induction	Role of osteopontin in induction of monocyte_chemoattractant_protein_1 and macrophage_inflammatory_protein_1beta through the NF-kappaB and MAPK pathways in rheumatoid_arthritis .
12127997	0	monocyte_chemoattractant_protein_1	16,50	transforming_growth_factor-beta_1	66,99	monocyte chemoattractant protein 1	transforming growth factor-beta 1	6347	7040	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of monocyte_chemoattractant_protein_1 and effects of transforming_growth_factor-beta_1 in Peyronie 's _ disease .
2161898	0	monocyte_chemotactic_and_activating_factor	14,56	MCAF	58,62	monocyte chemotactic and activating factor	MCAF	6347	6347	Gene	Gene	Properties|nmod|START_ENTITY Properties|appos|END_ENTITY	Properties of monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- purified from a human fibrosarcoma cell line .
2471522	0	monocyte_chemotactic_and_activating_factor	14,56	MCAF	58,62	monocyte chemotactic and activating factor	MCAF	6347	6347	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of monocyte_chemotactic_and_activating_factor -LRB- MCAF -RRB- by human dermal fibroblasts in response to interleukin 1 or tumor_necrosis_factor .
7963719	0	monocyte_chemotactic_and_activating_factor	24,66	monocyte_chemoattractant_protein_1	67,101	monocyte chemotactic and activating factor	monocyte chemoattractant protein 1	6347	6347	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Selective expression of monocyte_chemotactic_and_activating_factor / monocyte_chemoattractant_protein_1 in human blood monocytes by Mycobacterium_tuberculosis .
10419877	0	monocyte_chemotactic_protein	51,79	CCR2	8,12	monocyte chemotactic protein	CCR2	6347	729230	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Loss of CCR2 expression and functional response to monocyte_chemotactic_protein -LRB- MCP-1 -RRB- during the differentiation of human monocytes : role of secreted MCP-1 in the regulation of the chemotactic response .
8107690	0	monocyte_chemotactic_protein	18,46	MCP-1	48,53	monocyte chemotactic protein	MCP-1	6347	6347	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of monocyte_chemotactic_protein -LRB- MCP-1 -RRB- in human vascular endothelium in vitro and in vivo .
15880558	0	monocyte_chemotactic_protein-1	19,49	Albumin	0,7	monocyte chemotactic protein-1	Albumin	24770(Tax:10116)	24186(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Albumin stimulates monocyte_chemotactic_protein-1 expression in rat embryonic mixed brain cells .
16410530	0	monocyte_chemotactic_protein-1	7,37	CCL2	46,50	monocyte chemotactic protein-1	CCL2	6347	6347	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Raised monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- / CCL2 in cerebrospinal fluid of patients with neuropsychiatric_lupus .
24764682	0	monocyte_chemotactic_protein-1	14,44	CCL2	45,49	monocyte chemotactic protein-1	CCL2	6347	6347	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of monocyte_chemotactic_protein-1 / CCL2 in gastric_cancer and its relationship with tumor_hypoxia .
12840897	0	monocyte_chemotactic_protein-1	55,85	IL-1_beta	10,19	monocyte chemotactic protein-1	IL-1 beta	6347	3553	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of IL-1_beta and TNF-alpha on the expression of monocyte_chemotactic_protein-1 in endometriotic cells .
10444270	0	monocyte_chemotactic_protein-1	84,114	MCP-1	116,121	monocyte chemotactic protein-1	MCP-1	6347	6347	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Low-density lipoproteins enhance transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- and monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- expression induced by cyclosporin in human mesangial cells .
10475624	0	monocyte_chemotactic_protein-1	35,65	MCP-1	67,72	monocyte chemotactic protein-1	MCP-1	6347	6347	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive protein expression of monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- by myelomonocytic cell lines and regulation of the secretion by anti- and proinflammatory stimuli .
15552841	0	monocyte_chemotactic_protein-1	22,52	MCP-1	54,59	monocyte chemotactic protein-1	MCP-1	100009130(Tax:9986)	100009130(Tax:9986)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Aortic expression of monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- gene in rabbits with experimental atherosclerosis -RSB- .
9927154	0	monocyte_chemotactic_protein-1	27,57	MCP-1	59,64	monocyte chemotactic protein-1	MCP-1	24770(Tax:10116)	24770(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- in transforming rat hepatic stellate cells .
19009499	0	monocyte_chemotactic_protein-1	34,64	Visfatin	0,8	monocyte chemotactic protein-1	Visfatin	6347	10135	Gene	Gene	cells|amod|START_ENTITY production|nmod|cells stimulates|dobj|production stimulates|nsubj|END_ENTITY	Visfatin stimulates production of monocyte_chemotactic_protein-1 and interleukin-6 in human vein umbilical endothelial cells .
9344869	0	monocyte_chemotactic_protein-1	49,79	beta-chemokine	33,47	monocyte chemotactic protein-1	beta-chemokine	6347	6352	Gene	Gene	MCP-1|amod|START_ENTITY MCP-1|amod|END_ENTITY	The inhibition of synthesis of a beta-chemokine , monocyte_chemotactic_protein-1 -LRB- MCP-1 -RRB- by progesterone .
10636491	0	monocyte_chemotactic_protein-1	41,71	beta2-microglobulin	20,39	monocyte chemotactic protein-1	beta2-microglobulin	6347	567	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Cerebrospinal fluid beta2-microglobulin , monocyte_chemotactic_protein-1 , and soluble tumour necrosis factor alpha receptors before and after treatment with lamivudine plus zidovudine or stavudine .
9743506	0	monocyte_chemotactic_protein-1	27,57	intercellular_adhesion_molecule-1	94,127	monocyte chemotactic protein-1	intercellular adhesion molecule-1	6347	3383	Gene	Gene	secretion|amod|START_ENTITY secretion|nmod|END_ENTITY	Activated platelets induce monocyte_chemotactic_protein-1 secretion and surface expression of intercellular_adhesion_molecule-1 on endothelial cells .
24939570	0	monocyte_chemotactic_protein-1	80,110	microRNA-21	124,135	monocyte chemotactic protein-1	microRNA-21	6347	406991	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Endothelial progenitors promote hepatocarcinoma intrahepatic metastasis through monocyte_chemotactic_protein-1 induction of microRNA-21 .
12439927	0	monocyte_chemotactic_protein-3	62,92	MCP-3	55,60	monocyte chemotactic protein-3	MCP-3	20306(Tax:10090)	20306(Tax:10090)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Transfection of colorectal_cancer cells with chemokine MCP-3 -LRB- monocyte_chemotactic_protein-3 -RRB- gene retards_tumor growth and inhibits_tumor metastasis .
9647242	0	monocyte_chemotactic_protein-3	66,96	MCP-3	98,103	monocyte chemotactic protein-3	MCP-3	20306(Tax:10090)	20306(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Reduced tumorigenicity and augmented leukocyte infiltration after monocyte_chemotactic_protein-3 -LRB- MCP-3 -RRB- gene transfer : perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor .
23374966	0	monocyte_chemotactic_protein-3	67,97	tissue_factor_pathway_inhibitor	14,45	monocyte chemotactic protein-3	tissue factor pathway inhibitor	6354	7035	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	The effect of tissue_factor_pathway_inhibitor on the expression of monocyte_chemotactic_protein-3 and IkB-a stimulated by tumour_necrosis_factor-a in cultured vascular smooth muscle cells .
11400154	0	monocyte_chemotactic_protein-4	19,49	MCP-4	51,56	monocyte chemotactic protein-4	MCP-4	6357	6357	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role for monocyte_chemotactic_protein-4 -LRB- MCP-4 -RRB- in monocyte/macrophage recruitment in acute_renal_inflammation .
19569526	0	monocytic_chemotaxic_protein-1	78,108	MCP-1	110,115	monocytic chemotaxic protein-1	MCP-1	6347	6347	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Development of a new anti-inflammatory peptide preparation -- inhibitor of the monocytic_chemotaxic_protein-1 -LRB- MCP-1 -RRB- -RSB- .
26997225	0	monoglyceride_lipase	105,125	Staphylococcal_nuclease_and_tudor_domain_containing_1	0,53	monoglyceride lipase	Staphylococcal nuclease and tudor domain containing 1	11343	27044	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Staphylococcal_nuclease_and_tudor_domain_containing_1 -LRB- SND1 -RRB- promotes hepatocarcinogenesis by inhibiting monoglyceride_lipase -LRB- MGLL -RRB- .
12403783	0	monokine_induced_by_interferon-gamma	153,189	CXC_ligand_9	140,152	monokine induced by interferon-gamma	CXC ligand 9	4283	4283	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The transcriptional coactivator CREB-binding_protein cooperates with STAT1 and NF-kappa_B for synergistic transcriptional activation of the CXC_ligand_9 / monokine_induced_by_interferon-gamma gene .
15959530	0	monokine_induced_by_interferon-gamma	85,121	MIG	123,126	monokine induced by interferon-gamma	MIG	17329(Tax:10090)	17329(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple_myeloma oncogene 1 -LRB- MUM1 -RRB- / interferon_regulatory_factor_4 -LRB- IRF4 -RRB- upregulates monokine_induced_by_interferon-gamma -LRB- MIG -RRB- gene expression in B-cell malignancy .
26828323	0	monokine_induced_by_interferon-gamma	8,44	MIG	46,49	monokine induced by interferon-gamma	MIG	4283	4283	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of monokine_induced_by_interferon-gamma -LRB- MIG -RRB- in discrimination and prognosis of patients with Chagas ' _ disease and idiopathic_dilated_cardiomyopathy .
11160225	0	monokine_induced_by_interferon-gamma	19,55	Mig	14,17	monokine induced by interferon-gamma	Mig	17329(Tax:10090)	17329(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Mig -LRB- monokine_induced_by_interferon-gamma -RRB- is important in T lymphocyte recruitment and host defense following viral_infection_of_the_central_nervous_system .
1762071	0	monomorphic_arylamine_N-acetyltransferase	14,55	NAT1	57,61	monomorphic arylamine N-acetyltransferase	NAT1	9	9	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of monomorphic_arylamine_N-acetyltransferase -LRB- NAT1 -RRB- in human leukocytes .
9199359	0	morphogen	16,25	Bmp-4	0,5	morphogen	Bmp-4	398047(Tax:8355)	397874(Tax:8355)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus .
9792667	0	mot-2	40,45	p53	33,36	mot-2	p53	15526(Tax:10090)	22060(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of tumor suppressor p53 by mot-2 , a hsp70 family member .
669076	0	motilin	11,18	cholecystokinin	38,53	motilin	cholecystokinin	481748(Tax:9615)	609547(Tax:9615)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of motilin and octapeptide of cholecystokinin on antral and duodenal myoelectric activity in the interdigestive state and during inhibition by secretin and gastric inhibitory polypeptide .
2875010	0	motilin	52,59	corticotropin-releasing_factor	11,41	motilin	corticotropin-releasing factor	481748(Tax:9615)	486977(Tax:9615)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_factor on plasma motilin and somatostatin levels and gastrointestinal_motility in dogs .
14714611	0	motilin	10,17	insulin	43,50	motilin	insulin	481748(Tax:9615)	483665(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of motilin on endogenous release of insulin in conscious dogs in the fed state .
955568	0	motilin	117,124	motilin	93,100	motilin	motilin	4295	4295	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The synthesis of motilin , I : Preparation of the sequence fragments 9 - 22 of -LSB- 13-norleucine -RSB- motilin and -LSB- 13-leucine -RSB- motilin -LRB- author 's transl -RRB- -RSB- .
955568	0	motilin	93,100	motilin	117,124	motilin	motilin	4295	4295	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The synthesis of motilin , I : Preparation of the sequence fragments 9 - 22 of -LSB- 13-norleucine -RSB- motilin and -LSB- 13-leucine -RSB- motilin -LRB- author 's transl -RRB- -RSB- .
2872717	1	motilin	93,100	somatostatin	149,161	motilin	somatostatin	4295	6750	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A study of plasma motilin and somatostatin during intravenous infusion of somatostatin , secretin , cholecystokinin , and gastric inhibitory polypeptide .
15476162	0	motility-related_protein-1	28,54	CD9	55,58	motility-related protein-1	CD9	928	928	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	-LSB- Differential expression of motility-related_protein-1 / CD9 gene in gastric_cancers and premalignant_lesions -RSB- .
8521390	0	motility_related_protein-1	8,34	CD9	42,45	motility related protein-1	CD9	928	928	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Reduced motility_related_protein-1 -LRB- MRP-1 / CD9 -RRB- gene expression as a factor of poor prognosis in non-small cell lung_cancer .
1976012	0	mouse_T_cell_associated_serine_proteinase-1	14,57	MTSP-1	59,65	mouse T cell associated serine proteinase-1	MTSP-1	19143(Tax:10090)	19143(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of mouse_T_cell_associated_serine_proteinase-1 -LRB- MTSP-1 -RRB- by proteinase inhibitors and sulfated polysaccharides .
11306105	0	mouse_vas_deferens_protein	51,77	AKR1B7	79,85	mouse vas deferens protein	AKR1B7	11997(Tax:10090)	11997(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Physiological functions and hormonal regulation of mouse_vas_deferens_protein -LRB- AKR1B7 -RRB- in steroidogenic tissues .
10975410	0	mouse_vas_deferens_protein	47,73	MVDP	75,79	mouse vas deferens protein	MVDP	11997(Tax:10090)	11997(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Acquisition of androgen-mediated expression of mouse_vas_deferens_protein -LRB- MVDP -RRB- gene in cultured epithelial cells and in vas deferens during postnatal development .
11983900	0	movo1	41,46	ovo	78,81	movo1	ovo	18426(Tax:10090)	31429(Tax:7227)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	The LEF1/beta _ - catenin complex activates movo1 , a mouse homolog of Drosophila ovo required for epidermal appendage differentiation .
11798719	0	mrp	120,123	multidrug_resistance-associated_protein	74,113	mrp	multidrug resistance-associated protein	4363	8714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	-LSB- The clinical significance of lung_resistance-related_protein gene -LRB- lrp -RRB- , multidrug_resistance-associated_protein gene -LRB- mrp -RRB- and mdr-1 / p170 expression in acute_leukemia -RSB- .
25896592	0	mrp2	46,50	Multidrug_Resistance_Protein_2	14,44	mrp2	Multidrug Resistance Protein 2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Multidrug_Resistance_Protein_2 -LRB- mrp2 -RRB- in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy .
9571149	0	mrp2	119,123	multidrug_resistance_protein_2	87,117	mrp2	multidrug resistance protein 2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Sequence analysis and functional characterization of the 5 ' - flanking region of the rat multidrug_resistance_protein_2 -LRB- mrp2 -RRB- gene .
14570762	0	mrp3	45,49	constitutive_androstane_receptor	77,109	mrp3	constitutive androstane receptor	18670(Tax:10090)	12355(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY independent|nsubj|Induction independent|nmod|END_ENTITY	Induction of multidrug_resistance_protein_3 -LRB- mrp3 -RRB- in vivo is independent of constitutive_androstane_receptor .
23923566	0	mrps28	48,54	mitochondrial_ribosomal_protein_s28	11,46	mrps28	mitochondrial ribosomal protein s28	28957	28957	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Variant of mitochondrial_ribosomal_protein_s28 -LRB- mrps28 -RRB- gene is differentially expressed in response to radiation in a cervical carcinoma derived cell line .
22431517	0	ms1/STARS	22,31	GATA4	107,112	ms1/STARS	GATA4	4397;137735	2626	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Cardiac expression of ms1/STARS , a novel gene involved in cardiac development and disease , is regulated by GATA4 .
15650878	0	msh2	103,107	ung	95,98	msh2	ung	4436	7374	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung -LRB- - / - -RRB- msh2 -LRB- - / - -RRB- mice .
16894013	0	msh2	103,107	ung	111,114	msh2	ung	17685(Tax:10090)	22256(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2 - / - ung - / - mice .
15199178	5	msh6	775,779	mlh1	712,716	mlh2	MLH3	850722(Tax:4932)	855939(Tax:4932)	Gene	Gene	strains|amod|START_ENTITY greater|nmod|strains greater|nmod|strains strains|amod|END_ENTITY	In mlh1 Delta strains , heteroduplex rejection was greater than in msh6 Delta strains but less than in wild type .
22110345	0	mss4	64,68	foxg1	36,41	mss4	foxg1	304807(Tax:10116)	24370(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene induces|dobj|expression induces|nsubj|END_ENTITY	A winged-helix transcription factor foxg1 induces expression of mss4 gene in rat hippocampal progenitor cells .
23527007	0	mst1	76,80	Glyceraldehyde-3-phosphate_dehydrogenase	0,40	mst1	Glyceraldehyde-3-phosphate dehydrogenase	4485	2597	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Glyceraldehyde-3-phosphate_dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis .
9272945	0	msx1	8,12	BMP4	67,71	msx1	BMP4	100125666(Tax:8355)	399322(Tax:8355)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|induction induction|nmod|END_ENTITY	Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4 .
17960876	0	mt-I	122,126	metallothionein-I	101,118	mt-I	metallothionein-I	17748(Tax:10090)	17748(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Improving zinc content and antioxidant activity in transgenic tomato plants with expression of mouse metallothionein-I by mt-I gene .
10884567	0	mt1	82,85	MT2	93,96	mt1	MT2	17748(Tax:10090)	17750(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Anxiolytic-like properties of melatonin receptor agonists in mice : involvement of mt1 and/or MT2 receptors in the regulation of emotional responsiveness .
10968369	0	mt1	101,104	MT2	118,121	mt1	MT2	4543	4544	Gene	Gene	Mel-1a|appos|START_ENTITY Mel-1a|appos|END_ENTITY	Production and characterization of antibodies directed against the human melatonin receptors Mel-1a -LRB- mt1 -RRB- and Mel-1b -LRB- MT2 -RRB- .
11316328	0	mt1	115,118	Mel1c	71,76	mt1	Mel1c	644314	9248	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Chimeric Galphaq subunits can distinguish the long form of the Xenopus Mel1c melatonin receptor from the mammalian mt1 and MT2 melatonin receptors .
11812653	0	mt1	10,13	c-Jun_N-terminal_kinase	42,65	mt1	c-Jun N-terminal kinase	644314	5599	Gene	Gene	stimulate|nsubj|START_ENTITY stimulate|dobj|END_ENTITY	Melatonin mt1 and MT2 receptors stimulate c-Jun_N-terminal_kinase via pertussis toxin-sensitive and - insensitive G proteins .
19885567	0	mtTFA	58,63	Thioredoxin2	0,12	mtTFA	Thioredoxin2	7019	25828	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Thioredoxin2 enhances the damaged DNA binding activity of mtTFA through direct interaction .
15585199	0	mtTFA	114,119	mitochondrial_transcription_factor_A	76,112	mtTFA	mitochondrial transcription factor A	83474(Tax:10116)	83474(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial_transcription_factor_A -LRB- mtTFA -RRB- expression in injured rat carotid artery .
10803111	0	mts1	19,23	S100A4	11,17	mts1	S100A4	6275	6275	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Absence of S100A4 -LRB- mts1 -RRB- gene mutations in various canine_and_feline_tumours .
15867373	0	mts1	85,89	S100A4	78,84	mts1	S100A4	20198(Tax:10090)	20198(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Suppression_of_tumor development and metastasis formation in mice lacking the S100A4 -LRB- mts1 -RRB- gene .
8824556	0	mts1	10,14	S100A4	16,22	mts1	S100A4	6275	6275	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of mts1 -LRB- S100A4 -RRB- expression on the progression of human breast_cancer cells .
7928629	0	mts1	62,66	pEL98	52,57	mts1	pEL98	20198(Tax:10090)	20198(Tax:10090)	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of S100-related calcium-binding protein pEL98 -LRB- or mts1 -RRB- in cell motility and tumor cell invasion .
15087125	0	mtx3	30,34	metaxin_3	14,23	mtx3	metaxin 3	402916(Tax:7955)	402916(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The zebrafish metaxin_3 gene -LRB- mtx3 -RRB- : cDNA and protein structure , and comparison to zebrafish metaxins_1_and_2 .
20107485	0	mu-Opioid_receptor	0,18	IL-13	33,38	mu-Opioid receptor	IL-13	4988	3596	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	mu-Opioid_receptor is induced by IL-13 within lymph nodes from patients with S zary syndrome .
19289571	0	mu-Opioid_receptor	0,18	Ribophorin_I	87,99	mu-Opioid receptor	Ribophorin I	4988	6184	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	mu-Opioid_receptor cell surface expression is regulated by its direct interaction with Ribophorin_I .
15523157	0	mu-calpain	7,17	CAPN1	19,24	mu-calpain	CAPN1	281661(Tax:9913)	281661(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Bovine mu-calpain -LRB- CAPN1 -RRB- gene : new SNP within intron 14 .
18213645	0	mu-opioid_receptor	35,53	MOR	55,58	mu-opioid receptor	MOR	100033967(Tax:9796)	100033967(Tax:9796)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of the mu-opioid_receptor -LRB- MOR -RRB- in the equine cumulus-oocyte complex and its involvement in the seasonal regulation of oocyte meiotic competence .
16122888	0	mu-opioid_receptor	60,78	MOR-1	80,85	mu-opioid receptor	MOR-1	4988	4988	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Characterization of the 3 ' untranslated region of the human mu-opioid_receptor -LRB- MOR-1 -RRB- mRNA .
19144786	0	mu-opioid_receptor	58,76	MOR1	78,82	mu-opioid receptor	MOR1	4988	4988	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Long-term morphine treatment decreases the association of mu-opioid_receptor -LRB- MOR1 -RRB- mRNA with polysomes through miRNA23b .
15558714	0	mu-opioid_receptor	13,31	OPRM1	38,43	mu-opioid receptor	OPRM1	4988	4988	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel exonic mu-opioid_receptor gene -LRB- OPRM1 -RRB- polymorphisms not associated with opioid_dependence .
16644048	0	mu-opioid_receptor	67,85	Oprm	92,96	mu-opioid receptor	Oprm	18390(Tax:10090)	18390(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and functional significance of polymorphisms in the mu-opioid_receptor gene -LRB- Oprm -RRB- promoter of C57BL/6 and DBA/2 mice .
15703380	0	mu_opioid_receptor	36,54	M1	75,77	mu opioid receptor	M1	18390(Tax:10090)	12669(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of mouse mu_opioid_receptor gene : Sp3 isoforms -LRB- M1 , M2 -RRB- function as repressors in neuronal cells to regulate the mu_opioid_receptor gene .
10712637	0	mu_opioid_receptor	27,45	MOR	47,50	mu opioid receptor	MOR	18390(Tax:10090)	18390(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Specific activation of the mu_opioid_receptor -LRB- MOR -RRB- by endomorphin 1 and endomorphin 2 .
17130167	0	mu_opioid_receptor	114,132	MOR	134,137	mu opioid receptor	MOR	18390(Tax:10090)	18390(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence of the neuron-restrictive silencer factor -LRB- NRSF -RRB- interaction with Sp3 and its synergic repression to the mu_opioid_receptor -LRB- MOR -RRB- gene .
7583338	0	mu_opioid_receptor	14,32	MOR-1	34,39	mu opioid receptor	MOR-1	25601(Tax:10116)	25601(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	CNS levels of mu_opioid_receptor -LRB- MOR-1 -RRB- mRNA during chronic treatment with morphine or naltrexone .
17990281	0	mu_opioid_receptor	112,130	Sp1	34,37	mu opioid receptor	Sp1	4988	6667	Gene	Gene	gene|compound|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu_opioid_receptor gene in human lymphocytes .
23353576	0	mu_opioid_receptor	60,78	Vimentin	0,8	mu opioid receptor	Vimentin	18390(Tax:10090)	22352(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Vimentin interacts with the 5 ' - untranslated region of mouse mu_opioid_receptor -LRB- MOR -RRB- and is required for post-transcriptional regulation .
16846840	0	mu_opioid_receptor	33,51	gp120	6,11	mu opioid receptor	gp120	4988	3700	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	HIV-1 gp120 up-regulation of the mu_opioid_receptor in TPA-differentiated HL-60 cells .
11506703	0	mu_opioid_receptor	40,58	hMOR	60,64	mu opioid receptor	hMOR	4988	4988	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the human mu_opioid_receptor -LRB- hMOR -RRB- gene : evidence of positive and negative cis-acting elements in the proximal promoter and presence of a distal promoter .
11936871	0	mu_opioid_receptor	64,82	hMOR	84,88	mu opioid receptor	hMOR	4988	4988	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional characterization of the promoter region of the human mu_opioid_receptor -LRB- hMOR -RRB- gene : identification of activating and inhibitory regions .
18716031	0	mu_opioid_receptor	41,59	microRNA23b	110,121	mu opioid receptor	microRNA23b	18390(Tax:10090)	387217(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Post-transcriptional regulation of mouse mu_opioid_receptor -LRB- MOR1 -RRB- via its 3 ' untranslated region : a role for microRNA23b .
19538730	0	muc16	37,42	ca125	44,49	muc16	ca125	73732(Tax:10090)	73732(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of the tumor marker muc16 -LRB- ca125 -RRB- expressed by murine ovarian_tumor cell lines and identification of a panel of cross-reactive monoclonal antibodies .
23695867	0	mucin	27,32	CD44	62,66	mucin	CD44	404104(Tax:9913)	281057(Tax:9913)	Gene	Gene	accumulation|compound|START_ENTITY accumulation|acl|associated associated|nmod|END_ENTITY	Cytoplasmic non-epithelial mucin accumulation associated with CD44 in an astrocytic_tumor with signet ring features .
18373244	0	mucin	53,58	CD8	22,25	mucin	CD8	100508689	925	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Quantification of the CD8 + T cell response against a mucin epitope in patients with breast_cancer .
10089213	0	mucin	75,80	CFTR	0,4	mucin	CFTR	100508689	1080	Gene	Gene	glycosylation|nmod|START_ENTITY influence|dobj|glycosylation influence|nsubj|expression expression|amod|END_ENTITY	CFTR expression does not influence glycosylation of an epitope-tagged MUC1 mucin in colon_carcinoma cell lines .
7524485	0	mucin	13,18	CFTR	39,43	mucin	CFTR	100508689	1080	Gene	Gene	secretion|compound|START_ENTITY linked|nsubj|secretion linked|nmod|expression expression|amod|END_ENTITY	Constitutive mucin secretion linked to CFTR expression .
9831904	0	mucin	95,100	CFTR	55,59	mucin	CFTR	65202(Tax:10116)	24255(Tax:10116)	Gene	Gene	response|compound|START_ENTITY response|compound|END_ENTITY	Actions of adenosine A1 and A2 receptor antagonists on CFTR antibody-inhibited beta-adrenergic mucin secretion response .
17646388	0	mucin	14,19	CREB	39,43	mucin	CREB	100508689	1385	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of mucin gene expression by CREB via a nonclassical retinoic_acid signaling pathway .
12749290	0	mucin	26,31	Cyclooxygenase-2	0,16	mucin	Cyclooxygenase-2	100508689	5743	Gene	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder .
11292614	0	mucin	14,19	E-selectin	29,39	mucin	E-selectin	100508689	6401	Gene	Gene	binds|compound|START_ENTITY binds|nmod|END_ENTITY	Human biliary mucin binds to E-selectin : a possible role in modulation of inflammation .
15347558	0	mucin	22,27	Endothelin-1	0,12	mucin	Endothelin-1	100508689	1906	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits mucin secretion from ovine airway epithelial goblet cells .
19429776	0	mucin	53,58	Fibrinogen	0,10	mucin	Fibrinogen	100508689	2244	Gene	Gene	production|compound|START_ENTITY promotes|dobj|production promotes|nsubj|END_ENTITY	Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells .
14986113	0	mucin	53,58	GATA-5	21,27	mucin	GATA-5	100508689	140628	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Transcription factor GATA-5 selectively up-regulates mucin gene expression .
22859374	0	mucin	31,36	Gab2	16,20	mucin	Gab2	100508689	9846	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway .
24854997	0	mucin	17,22	Galectin-1	0,10	mucin	Galectin-1	100508689	3956	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Galectin-1 binds mucin in human trophoblast .
11133503	0	mucin	14,19	IL-13	0,5	mucin	IL-13	100508689	3596	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	IL-13 induces mucin production by stimulating epidermal_growth_factor_receptors and by activating neutrophils .
16980555	0	mucin	95,100	IL-13	0,5	mucin	IL-13	100508689	3596	Gene	Gene	production|compound|START_ENTITY roles|nmod|production have|dobj|roles have|nsubj|END_ENTITY	IL-13 and epidermal_growth_factor_receptor have critical but distinct roles in epithelial cell mucin production .
19596978	0	mucin	15,20	IL-8	0,4	mucin	IL-8	100508689	3576	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells .
23168839	0	mucin	65,70	IRE1b	25,30	mucin	IRE1b	100508689	10595	Gene	Gene	production|compound|START_ENTITY required|nmod|production required|nsubjpass|END_ENTITY	The ER stress transducer IRE1b is required for airway epithelial mucin production .
10738572	0	mucin	14,19	MUC-1	21,26	mucin	MUC-1	100508689	4582	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of mucin -LRB- MUC-1 -RRB- from a mini-Epstein-Barr_virus in immortalized B-cells to generate tumor antigen specific cytotoxic T cells .
7686886	0	mucin	118,123	MUC-1	101,106	mucin	MUC-1	100508689	4582	Gene	Gene	core|compound|START_ENTITY core|amod|epithelial epithelial|amod|END_ENTITY	Development of an anti-idiotypic antibody reactive with an antibody defining the epitope RPAP in the MUC-1 epithelial mucin core .
8443822	0	mucin	99,104	MUC-1	93,98	mucin	MUC-1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Mucin synthesis and secretion in various human epithelial_cancer cell lines that express the MUC-1 mucin gene .
8643693	0	mucin	80,85	MUC-1	106,111	mucin	MUC-1	100508689	4582	Gene	Gene	START_ENTITY|nmod|cells cells|amod|cDNA-transfected cDNA-transfected|amod|END_ENTITY	Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr_virus-immortalized autologous B cells .
8706053	0	mucin	40,45	MUC-1	33,38	mucin	MUC-1	100508689	4582	Gene	Gene	level|compound|START_ENTITY level|appos|END_ENTITY	Pre-immunotherapy serum CA27 .29 -LRB- MUC-1 -RRB- mucin level and CD69 + lymphocytes correlate with effects of Theratope sialyl-Tn-KLH cancer vaccine in active specific immunotherapy .
9101416	0	mucin	66,71	MUC-1	59,64	mucin	MUC-1	100508689	4582	Gene	Gene	level|compound|START_ENTITY level|appos|END_ENTITY	Prognostic significance of preimmunotherapy serum CA27 .29 -LRB- MUC-1 -RRB- mucin level after active specific immunotherapy of metastatic adenocarcinoma patients .
9212228	0	mucin	20,25	MUC-1	14,19	mucin	MUC-1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Comparison of MUC-1 mucin expression in epithelial and non-epithelial cancer cell lines and demonstration of a new short variant form -LRB- MUC-1 / Z -RRB- .
9346852	0	mucin	108,113	MUC-1	35,40	mucin	MUC-1	100508689	4582	Gene	Gene	resembles|nsubj|START_ENTITY resembles|dep|expressed expressed|nsubj|mucin mucin|appos|END_ENTITY	Recombinant epithelial cell mucin -LRB- MUC-1 -RRB- expressed in baculovirus resembles antigenically tumor associated mucin , target for cancer immunotherapy .
12471471	0	mucin	29,34	MUC-2	23,28	mucin	MUC-2	100508689	4583	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Probiotics up-regulate MUC-2 mucin gene expression in a Caco-2 cell-culture model .
12632359	0	mucin	6,11	MUC-2	0,5	mucin	MUC-2	100508689	4583	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	MUC-2 mucin production in Hirschsprung 's _ disease : possible association with enterocolitis development .
1477935	0	mucin	30,35	MUC-2	53,58	mucin	MUC-2	100508689	4583	Gene	Gene	core|compound|START_ENTITY localization|nmod|core polypeptide|nsubj|localization polypeptide|xcomp|END_ENTITY	-LSB- Histological localization of mucin core polypeptide MUC-2 in application to the differential diagnosis of adenocarcinoma -RSB- .
10398137	0	mucin	28,33	MUC1	14,18	mucin	MUC1	100508689	4582	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall_bladder_carcinoma : an immunohistochemical and in situ hybridization study .
10459625	0	mucin	23,28	MUC1	42,46	mucin	MUC1	100508689	4582	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein END_ENTITY|nsubj|expression	Frequent expression of mucin core protein MUC1 in non-neoplastic_gallbladder mucosa from patients with pancreaticobiliary maljunction .
10583575	0	mucin	28,33	MUC1	14,18	mucin	MUC1	100508689	4582	Gene	Gene	products|compound|START_ENTITY products|compound|END_ENTITY	Expression of MUC1 and MUC2 mucin gene products in Barrett 's _ metaplasia , dysplasia and adenocarcinoma : an immunopathological study with clinical correlation .
10936782	0	mucin	32,37	MUC1	27,31	mucin	MUC1	100508689	4582	Gene	Gene	START_ENTITY|nsubj|Detection Detection|nmod|END_ENTITY	Detection and isolation of MUC1 mucin from larynx_squamous_cell_carcinoma .
11009623	0	mucin	71,76	MUC1	78,82	mucin	MUC1	4582	4582	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structural effects of O-glycosylation on a 15-residue peptide from the mucin -LRB- MUC1 -RRB- core protein .
11173916	0	mucin	5,10	MUC1	0,4	mucin	MUC1	100508689	4582	Gene	Gene	protein|amod|START_ENTITY protein|nummod|END_ENTITY	MUC1 mucin core protein binds to the domain 1 of ICAM-1 .
12000758	0	mucin	113,118	MUC1	12,16	mucin	MUC1	100508689	4582	Gene	Gene	profiles|nmod|START_ENTITY reflects|dobj|profiles reflects|nsubj|probe probe|compound|END_ENTITY	Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast_cancer mucin .
12529261	0	mucin	41,46	MUC1	6,10	mucin	MUC1	100508689	17829(Tax:10090)	Gene	Gene	contribute|xcomp|START_ENTITY contribute|nsubj|variants variants|compound|END_ENTITY	Novel MUC1 splice variants contribute to mucin overexpression in CFTR-deficient mice .
12578901	0	mucin	28,33	MUC1	14,18	mucin	MUC1	100508689	4582	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of MUC1 and MUC2 mucin gene products in human ovarian_carcinomas .
1289420	0	mucin	29,34	MUC1	24,28	mucin	MUC1	100508689	4582	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Expression of the human MUC1 mucin cDNA in a hamster pancreatic_tumor cell line HP-1 .
12925576	0	mucin	117,122	MUC1	30,34	mucin	MUC1	100508689	4582	Gene	Gene	core|compound|START_ENTITY O-glycosylation|nmod|core implication|nmod|O-glycosylation studies|dep|implication studies|nmod|glycopeptides glycopeptides|nummod|END_ENTITY	Conformational studies on the MUC1 tandem repeat glycopeptides : implication for the enzymatic O-glycosylation of the mucin protein core .
15944787	0	mucin	25,30	MUC1	20,24	mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Polymorphism of the MUC1 mucin gene is associated with susceptibility to lung_adenocarcinoma and poor prognosis .
17213039	0	mucin	41,46	MUC1	61,65	mucin	MUC1	100508689	4582	Gene	Gene	immunoexpression|nmod|START_ENTITY Relationship|nmod|immunoexpression peptide|nsubj|Relationship peptide|dobj|cores cores|nummod|END_ENTITY	Relationship between immunoexpression of mucin peptide cores MUC1 and MUC2 and Lauren 's histologic subtypes of gastric_carcinomas .
18154934	0	mucin	19,24	MUC1	14,18	mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Activation of MUC1 mucin expression by bile_acids in human esophageal_adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase .
19631667	0	mucin	19,24	MUC1	34,38	mucin	MUC1	100508689	4582	Gene	Gene	START_ENTITY|appos|mucin mucin|compound|END_ENTITY	Expression of KL-6 mucin , a human MUC1 mucin , in intrahepatic_cholangiocarcinoma and its potential involvement in tumor cell adhesion and invasion .
20598042	0	mucin	14,19	MUC1	30,34	mucin	MUC1	100508689	4582	Gene	Gene	antigens|compound|START_ENTITY Expression|nmod|antigens Expression|appos|END_ENTITY	Expression of mucin antigens -LRB- MUC1 and MUC16 -RRB- as a prognostic factor for mucinous_adenocarcinoma_of_the_uterine_cervix .
21071348	0	mucin	19,24	MUC1	14,18	mucin	MUC1	100508689	4582	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of MUC1 mucin in human umbilical vein endothelial cells -LRB- HUVEC -RRB- .
23566254	0	mucin	14,19	MUC1	20,24	mucin	MUC1	100508689	4582	Gene	Gene	overexpression|compound|START_ENTITY overexpression|compound|END_ENTITY	Transmembrane mucin MUC1 overexpression and its association with CD10 myeloid cells , transforming_growth_factor-b1 expression , and tumor budding grade in colorectal_cancer .
7588808	0	mucin	53,58	MUC1	48,52	mucin	MUC1	100508689	4582	Gene	Gene	START_ENTITY|nsubj|glycosylation glycosylation|nmod|END_ENTITY	Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast_cancer cells .
7591241	0	mucin	76,81	MUC1	60,64	mucin	MUC1	100508689	4582	Gene	Gene	epithelial|dobj|START_ENTITY epithelial|nsubj|secretion secretion|nmod|END_ENTITY	Heterogeneity in production , secretion and glycosylation of MUC1 epithelial mucin by primary cultures of ovarian_carcinoma .
7685318	0	mucin	67,72	MUC1	87,91	mucin	MUC1	100508689	4582	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Detection of a circulating antibody against a peptide epitope on a mucin core protein , MUC1 , in ulcerative_colitis .
7705823	0	mucin	43,48	MUC1	27,31	mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY epithelial|dobj|expression epithelial|nsubj|significance significance|nmod|END_ENTITY	Prognostic significance of MUC1 epithelial mucin expression in breast_cancer .
7842630	0	mucin	49,54	MUC1	44,48	mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian_carcinoma cell lines .
7905449	0	mucin	5,10	MUC1	0,4	mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MUC1 mucin expression as a marker of progression and metastasis of human colorectal_carcinoma .
8157358	0	mucin	40,45	MUC1	14,18	mucin	MUC1	100508689	4582	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of MUC1 , MUC2 , MUC3 and MUC4 mucin mRNAs in human pancreatic_and_intestinal_tumor cell lines .
8195140	0	mucin	39,44	MUC1	34,38	mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Transcriptional regulation of the MUC1 mucin gene in colon_carcinoma cells by a soluble factor .
8308060	0	mucin	37,42	MUC1	49,53	mucin	MUC1	100508689	4582	Gene	Gene	expression|nmod|START_ENTITY genes|nsubj|expression genes|dobj|MUC5 MUC5|compound|END_ENTITY	Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations .
8422670	0	mucin	100,105	MUC1	215,219	mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY encoded|nmod|gene sequence|acl|encoded related|nmod|sequence related|parataxis|transfected transfected|nmod|gene gene|compound|END_ENTITY	Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene : effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene .
8422670	0	mucin	100,105	MUC1	95,99	mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene : effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene .
8638091	0	mucin	59,64	MUC1	16,20	mucin	MUC1	4585	4582	Gene	Gene	START_ENTITY|nsubj|Membrane-bound Membrane-bound|appos|END_ENTITY	Membrane-bound -LRB- MUC1 -RRB- and secretory -LRB- MUC2 , MUC3 , and MUC4 -RRB- mucin gene expression in human lung_cancer .
8813954	0	mucin	30,35	MUC1	16,20	mucin	MUC1	100508689	4582	Gene	Gene	START_ENTITY|nsubj|Significance Significance|nmod|END_ENTITY	Significance of MUC1 and MUC2 mucin expression in colorectal_cancer .
9349575	0	mucin	5,10	MUC1	0,4	mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	MUC1 mucin gene , transcripts , and protein in adenomas and papillary_carcinomas of the thyroid .
9569234	0	mucin	100,105	MUC1	39,43	mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY correlation|nmod|expression analysis|dep|correlation analysis|nmod|END_ENTITY	Quantitative analysis of mRNA encoding MUC1 , MUC2 , and MUC5AC genes : a correlation between specific mucin gene expression and sialomucin expression in non-small cell lung_cancer .
9579577	0	mucin	73,78	MUC1	57,61	mucin	MUC1	100508689	4582	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Peritoneal fluid from ovarian_cancer patients stimulates MUC1 epithelial mucin expression in ovarian_cancer cell lines .
9583726	0	mucin	53,58	MUC1	73,77	mucin	MUC1	100508689	4582	Gene	Gene	reactivity|nmod|START_ENTITY Correlation|nmod|reactivity peptide|nsubj|Correlation peptide|dobj|cores cores|nummod|END_ENTITY	Correlation of the immunohistochemical reactivity of mucin peptide cores MUC1 and MUC2 with the histopathological subtype and prognosis of gastric_carcinomas .
9722669	0	mucin	85,90	MUC1	80,84	mucin	MUC1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Purification of nuclear proteins that potentially regulate transcription of the MUC1 mucin gene induced by a soluble factor .
9751614	0	mucin	19,24	MUC1	80,84	mucin	MUC1	100508689	4582	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|implications implications|nmod|role role|nmod|END_ENTITY	Expression of MUC1 mucin on activated human T cells : implications for a role of MUC1 in normal immune regulation .
9804253	0	mucin	69,74	MUC1	76,80	mucin	MUC1	100508689	4582	Gene	Gene	membrane-associated|appos|START_ENTITY specialization|nmod|membrane-associated specialization|appos|END_ENTITY	Regional specialization of the cell membrane-associated , polymorphic mucin -LRB- MUC1 -RRB- in human uterine epithelia .
12898407	0	mucin	78,83	MUC13	48,53	mucin	MUC13	100508689	56667	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	-LSB- Normal human conjunctival epithelium expresses MUC13 , MUC15 , MUC16 and MUC17 mucin genes -RSB- .
17582096	0	mucin	84,89	MUC15	54,59	mucin	MUC15	404104(Tax:9913)	337919(Tax:9913)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of carbohydrate structures of bovine MUC15 and distribution of the mucin in bovine milk .
10070955	0	mucin	69,74	MUC2	82,86	mucin	MUC2	100508689	4583	Gene	Gene	expression|compound|START_ENTITY expression|dep|MUC1 MUC1|appos|END_ENTITY	Intestinal metaplasia of human stomach displays distinct patterns of mucin -LRB- MUC1 , MUC2 , MUC5AC , and MUC6 -RRB- expression .
10872659	0	mucin	43,48	MUC2	27,31	mucin	MUC2	100508689	4583	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Differential expression of MUC2 and MUC5AC mucin genes in primary ovarian and metastatic colonic_carcinoma .
11062147	0	mucin	22,27	MUC2	77,81	mucin	MUC2	100508689	4583	Gene	Gene	genes|compound|START_ENTITY Polymorphism|nmod|genes Polymorphism|dep|significance significance|nmod|END_ENTITY	Polymorphism of human mucin genes in chest_disease : possible significance of MUC2 .
11368880	0	mucin	29,34	MUC2	35,39	mucin	MUC2	100508689	4583	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Regulation of the intestinal mucin MUC2 gene expression in vivo : evidence for the role of promoter methylation .
12490305	0	mucin	64,69	MUC2	59,63	mucin	MUC2	100508689	4583	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric_carcinomas .
15345696	0	mucin	31,36	MUC2	43,47	mucin	MUC2	100508689	4583	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Adenosine up-regulation of the mucin gene , MUC2 , in asthma .
16285957	0	mucin	26,31	MUC2	21,25	mucin	MUC2	100508689	4583	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Galectin-3 modulates MUC2 mucin expression in human colon_cancer cells at the level of transcription via AP-1 activation .
17674761	0	mucin	23,28	MUC2	18,22	mucin	MUC2	100508689	4583	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Up-regulation of MUC2 mucin gene in chronic rhinosinusitis -RSB- .
18493590	0	mucin	15,20	MUC2	92,96	mucin	MUC2	100508689	4583	Gene	Gene	expression|compound|START_ENTITY Alterations|nmod|expression Alterations|dep|analysis analysis|nmod|MUC6 MUC6|compound|END_ENTITY	Alterations in mucin expression in ovarian_mucinous_tumors : immunohistochemical analysis of MUC2 , MUC5AC , MUC6 , and CD10 expression .
1980995	0	mucin	41,46	MUC2	53,57	mucin	MUC2	100508689	4583	Gene	Gene	gene|compound|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of the polymorphic intestinal mucin gene -LRB- MUC2 -RRB- to chromosome 11p15 .
7492301	0	mucin	44,49	MUC2	39,43	mucin	MUC2	100508689	4583	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Regulated and unregulated pathways for MUC2 mucin secretion in human colonic LS180 adenocarcinoma cells are distinct .
8020672	0	mucin	16,21	MUC2	23,27	mucin	MUC2	100508689	4583	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of mucin -LRB- MUC2 and MUC3 -RRB- messenger RNA and peptide expression in human normal intestine and colon_cancer .
8143972	0	mucin	43,48	MUC2	22,26	mucin	MUC2	100508689	4583	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Altered expression of MUC2 , MUC4 , and MUC5 mucin genes in pancreas tissues and cancer cell lines .
8227409	0	mucin	30,35	MUC2	14,18	mucin	MUC2	100508689	4583	Gene	Gene	epithelial|dobj|START_ENTITY epithelial|nsubj|Expression Expression|nmod|END_ENTITY	Expression of MUC2 epithelial mucin in breast_carcinoma .
8838089	0	mucin	59,64	MUC2	45,49	mucin	MUC2	100508689	4583	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	-LSB- Mucin gene -- regulation of the expression of MUC2 and MUC3 mucin gene in the airway -RSB- .
8948445	0	mucin	116,121	MUC2	10,14	mucin	MUC2	100508689	4583	Gene	Gene	epitopes|nmod|START_ENTITY dimerize|nmod|epitopes appears|xcomp|dimerize appears|nsubj|apoprotein apoprotein|compound|END_ENTITY	The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the ` insoluble ' mucin of rat small intestine .
8948445	0	mucin	15,20	MUC2	10,14	mucin	MUC2	100508689	4583	Gene	Gene	apoprotein|compound|START_ENTITY apoprotein|compound|END_ENTITY	The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the ` insoluble ' mucin of rat small intestine .
8997274	0	mucin	16,21	MUC2	59,63	mucin	MUC2	100508689	4583	Gene	Gene	RNA|compound|START_ENTITY Quantitation|nmod|RNA reveals|nsubj|Quantitation reveals|dobj|induction induction|nmod|END_ENTITY	Quantitation of mucin RNA by PCR reveals induction of both MUC2 and MUC5AC mRNA levels by retinoids .
9035693	0	mucin	51,56	MUC2	35,39	mucin	MUC2	100508689	4583	Gene	Gene	epithelial|dobj|START_ENTITY epithelial|nsubj|steps steps|nmod|biosynthesis biosynthesis|nmod|END_ENTITY	Early steps in the biosynthesis of MUC2 epithelial mucin in colon_cancer cells .
9065467	0	mucin	60,65	MUC2	72,76	mucin	MUC2	100508689	4583	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Organization and regulatory aspects of the human intestinal mucin gene -LRB- MUC2 -RRB- locus .
9224654	0	mucin	66,71	MUC2	43,47	mucin	MUC2	100508689	4583	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Identification and characterization of the MUC2 -LRB- human intestinal mucin -RRB- gene 5 ' - flanking region : promoter activity in cultured cells .
9422745	0	mucin	6,11	MUC2	18,22	mucin	MUC2	100508689	4583	Gene	Gene	START_ENTITY|ccomp|express express|nsubj|genes genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9569234	0	mucin	100,105	MUC2	45,49	mucin	MUC2	100508689	4583	Gene	Gene	expression|compound|START_ENTITY correlation|nmod|expression analysis|dep|correlation analysis|nmod|MUC1 MUC1|nummod|END_ENTITY	Quantitative analysis of mRNA encoding MUC1 , MUC2 , and MUC5AC genes : a correlation between specific mucin gene expression and sialomucin expression in non-small cell lung_cancer .
9722984	0	mucin	42,47	MUC2	4,8	mucin	MUC2	100508689	4583	Gene	Gene	product|dep|START_ENTITY product|compound|END_ENTITY	The MUC2 gene product : a human intestinal mucin .
9922317	0	mucin	90,95	MUC2	85,89	mucin	MUC2	100508689	4583	Gene	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Liver colonization by human colon_cancer cells is reduced by antisense inhibition of MUC2 mucin synthesis .
12508093	0	mucin	116,121	MUC3	111,115	mucin	MUC3	100508689	100133790	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The conserved TFLK motif of mammary-associated serum amyloid A3 is responsible for up-regulation of intestinal MUC3 mucin expression in vitro .
12740338	0	mucin	19,24	MUC3	14,18	mucin	MUC3	100508689	100133790	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Extracellular MUC3 mucin secretion follows adherence of Lactobacillus strains to intestinal epithelial cells in vitro .
1362870	0	mucin	40,45	MUC3	51,55	mucin	MUC3	100508689	100133790	Gene	Gene	gene|compound|START_ENTITY localization|nmod|gene END_ENTITY|nsubj|localization	Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22 .
9422745	0	mucin	6,11	MUC3	24,28	mucin	MUC3	100508689	100133790	Gene	Gene	START_ENTITY|ccomp|express express|nsubj|genes genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9931338	0	mucin	81,86	MUC3	93,97	mucin	MUC3	100508689	100133790	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of ulcerative_colitis with rare VNTR alleles of the human intestinal mucin gene , MUC3 .
11418607	0	mucin	26,31	MUC4	37,41	mucin	MUC4	100508689	4585	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Characterization of human mucin gene MUC4 promoter : importance of growth factors and proinflammatory cytokines for its regulation in pancreatic_cancer cells .
11596032	0	mucin	17,22	MUC4	12,16	mucin	MUC4	100508689	4585	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Analysis of MUC4 mucin expression in lung_carcinoma cells and its immunogenicity .
12153560	0	mucin	29,34	MUC4	24,28	mucin	MUC4	100508689	4585	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization of MUC4 mucin gene .
14760381	0	mucin	5,10	MUC4	0,4	mucin	MUC4	100508689	4585	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	MUC4 mucin expression in human pancreatic_tumours is affected by organ environment : the possible role of TGFbeta2 .
16007204	0	mucin	34,39	MUC4	29,33	mucin	MUC4	100508689	4585	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic_acid in human pancreatic_tumour cells involves a reprogramming of signalling pathways .
20591909	0	mucin	30,35	MUC4	25,29	mucin	MUC4	100508689	4585	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Aberrant upregulation of MUC4 mucin expression in cutaneous_condyloma_acuminatum and squamous_cell_carcinoma suggests a potential role in the diagnosis and therapy of skin_diseases .
9422745	0	mucin	6,11	MUC4	30,34	mucin	MUC4	100508689	4585	Gene	Gene	START_ENTITY|ccomp|express express|nsubj|genes genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
10070955	0	mucin	69,74	MUC5AC	88,94	mucin	MUC5AC	100508689	4586	Gene	Gene	expression|compound|START_ENTITY expression|dep|MUC1 MUC1|appos|MUC2 MUC2|nummod|END_ENTITY	Intestinal metaplasia of human stomach displays distinct patterns of mucin -LRB- MUC1 , MUC2 , MUC5AC , and MUC6 -RRB- expression .
10681391	0	mucin	52,57	MUC5AC	102,108	mucin	MUC5AC	100508689	4586	Gene	Gene	expression|nmod|START_ENTITY study|nmod|expression study|appos|END_ENTITY	Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins -LRB- MUC5AC and MUC2 -RRB- in human gastric_carcinomas .
11052828	0	mucin	82,87	MUC5AC	31,37	mucin	MUC5AC	100508689	4586	Gene	Gene	hypersecretion|compound|START_ENTITY aspects|nmod|hypersecretion TNF-alpha|dep|aspects TNF-alpha|nmod|regulation regulation|nmod|secretion secretion|compound|END_ENTITY	TNF-alpha in the regulation of MUC5AC secretion : some aspects of cytokine-induced mucin hypersecretion on the in vitro model .
11415465	0	mucin	96,101	MUC5AC	89,95	mucin	MUC5AC	100508689	4586	Gene	Gene	peptides|compound|START_ENTITY peptides|compound|END_ENTITY	Glycopeptide N-acetylgalactosaminyltransferase specificities for O-glycosylated sites on MUC5AC mucin motif peptides .
11698399	0	mucin	90,95	MUC5AC	83,89	mucin	MUC5AC	100508689	4586	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Novel cytoplasmic proteins of nontypeable Haemophilus_influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway .
11923240	0	mucin	36,41	MUC5AC	42,48	mucin	MUC5AC	100508689	4586	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nsubj|levels	Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sj gren syndrome .
15210557	0	mucin	34,39	MUC5AC	17,23	mucin	MUC5AC	100508689	4586	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in chronic rhinosinusitis .
16055478	0	mucin	66,71	MUC5AC	59,65	mucin	MUC5AC	100508689	4586	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	E-cadherin promotes EGFR-mediated cell differentiation and MUC5AC mucin expression in cultured human airway epithelial cells .
16148149	0	mucin	35,40	MUC5AC	28,34	mucin	MUC5AC	100508689	4586	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C , reactive_oxygen_species , and TNF-alpha-converting_enzyme .
16425564	0	mucin	39,44	MUC5AC	32,38	mucin	MUC5AC	100508689	4586	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical analyses of MUC5AC mucin expression in sinus mucosa of children with sinusitis and controls .
16491824	0	mucin	34,39	MUC5AC	27,33	mucin	MUC5AC	100508689	4586	Gene	Gene	synthesis|compound|START_ENTITY synthesis|compound|END_ENTITY	Neutrophil elastase causes MUC5AC mucin synthesis via EGF receptor , ERK and NF-kB pathways in A549 cells .
16540890	0	mucin	34,39	MUC5AC	17,23	mucin	MUC5AC	100508689	4586	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric_otitis media with effusion .
17356062	0	mucin	51,56	MUC5AC	13,19	mucin	MUC5AC	100508689	4586	Gene	Gene	displays|compound|START_ENTITY product|nmod|displays product|compound|END_ENTITY	The isolated MUC5AC gene product from human ocular mucin displays intramolecular conformational heterogeneity .
17471237	0	mucin	76,81	MUC5AC	95,101	mucin	MUC5AC	100508689	4586	Gene	Gene	genes|compound|START_ENTITY genes|appos|MUC2 MUC2|dep|END_ENTITY	Epigenetic regulation -LRB- DNA methylation , histone modifications -RRB- of the 11p15 mucin genes -LRB- MUC2 , MUC5AC , MUC5B , MUC6 -RRB- in epithelial cancer cells .
17555715	0	mucin	67,72	MUC5AC	60,66	mucin	MUC5AC	100508689	4586	Gene	Gene	roles|acl|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF .
17621824	0	mucin	35,40	MUC5AC	18,24	mucin	MUC5AC	100508689	4586	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic_rhinosinusitis and nasal_polyposis .
18493590	0	mucin	15,20	MUC5AC	98,104	mucin	MUC5AC	100508689	4586	Gene	Gene	expression|compound|START_ENTITY Alterations|nmod|expression Alterations|dep|analysis analysis|nmod|MUC6 MUC6|dep|END_ENTITY	Alterations in mucin expression in ovarian_mucinous_tumors : immunohistochemical analysis of MUC2 , MUC5AC , MUC6 , and CD10 expression .
19288529	0	mucin	71,76	MUC5AC	64,70	mucin	MUC5AC	100508689	4586	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Genistein and curcumin suppress epidermal_growth_factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells .
19956440	0	mucin	73,78	MUC5AC	66,72	mucin	MUC5AC	100508689	4586	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of Streptococcus_pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways .
21146382	0	mucin	28,33	MUC5AC	21,27	mucin	MUC5AC	100508689	4586	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	Inhibition of airway MUC5AC mucin production and gene expression induced by epidermal growth factor or phorbol_ester by glycyrrhizin and carbenoxolone .
21442679	2	mucin	146,151	MUC5AC	139,145	mucin	MUC5AC	100508689	4586	Gene	Gene	production|compound|START_ENTITY production|compound|END_ENTITY	suppress epidermal growth factor - and phorbol_ester-induced MUC5AC mucin production and gene expression from human airway epithelial cells .
21512244	0	mucin	69,74	MUC5AC	62,68	mucin	MUC5AC	100508689	4586	Gene	Gene	production|compound|START_ENTITY production|nummod|END_ENTITY	Inhibition of E-cadherin dependent cell-cell contact promotes MUC5AC mucin production through the activation of epidermal_growth_factor receptors .
22388989	0	mucin	56,61	MUC5AC	49,55	mucin	MUC5AC	100508689	4586	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Phorbol_ester or epidermal_growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin .
24496642	0	mucin	14,19	MUC5AC	26,32	mucin	MUC5AC	100508689	4586	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of mucin mRNA -LRB- MUC5AC and MUC5B -RRB- expression and protein production and secretion in Caco-2 / HT29-MTX co-cultures following exposure to individual and combined Fusarium mycotoxins .
25872410	0	mucin	20,25	MUC5AC	13,19	mucin	MUC5AC	100508689	4586	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region .
25872410	0	mucin	20,25	MUC5AC	13,19	mucin	MUC5AC	100508689	4586	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of MUC5AC mucin expression by histamine through the activation of its core promoter region .
7826332	0	mucin	92,97	MUC5AC	41,47	mucin	MUC5AC	100508689	4586	Gene	Gene	genes|compound|START_ENTITY domain|nmod|genes Characterization|dep|domain Characterization|nmod|END_ENTITY	Characterization of the human mucin gene MUC5AC : a consensus cysteine-rich domain for 11p15 mucin genes ?
8536891	0	mucin	31,36	MUC5AC	43,49	mucin	MUC5AC	100508689	4586	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|appos|END_ENTITY	Aberrant expression of a human mucin gene -LRB- MUC5AC -RRB- in rectosigmoid_villous_adenoma .
9422745	0	mucin	6,11	MUC5AC	36,42	mucin	MUC5AC	100508689	4586	Gene	Gene	START_ENTITY|ccomp|express express|nsubj|genes genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
9506983	0	mucin	73,78	MUC5AC	66,72	mucin	MUC5AC	100508689	4586	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Cloning of the amino-terminal and 5 ' - flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts .
9587664	0	mucin	69,74	MUC5AC	75,81	mucin	MUC5AC	100508689	4586	Gene	Gene	motif|amod|START_ENTITY motif|compound|END_ENTITY	Polypeptide : N-acetylgalactosaminyltransferase activities towards the mucin MUC5AC peptide motif using microsomal preparations of normal and tumoral digestive mucosa .
9620876	0	mucin	134,139	MUC5AC	51,57	mucin	MUC5AC	100508689	4586	Gene	Gene	family|compound|START_ENTITY gene|nmod|family evidence|nmod|gene organization|dep|evidence organization|dep|region region|nmod|gene gene|compound|END_ENTITY	Genomic organization of the 3 ' - region of the human MUC5AC mucin gene : additional evidence for a common ancestral gene for the 11p15 .5 mucin gene family .
9620876	0	mucin	58,63	MUC5AC	51,57	mucin	MUC5AC	100508689	4586	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the 3 ' - region of the human MUC5AC mucin gene : additional evidence for a common ancestral gene for the 11p15 .5 mucin gene family .
9935202	0	mucin	47,52	MUC5AC	23,29	mucin	MUC5AC	100508689	4586	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Aberrant expression of MUC5AC and MUC6 gastric mucin genes in colorectal_polyps .
10764016	0	mucin	24,29	MUC5B	18,23	mucin	MUC5B	100508689	727897	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Identification of MUC5B mucin gene in human middle ear with chronic_otitis_media .
16540890	0	mucin	34,39	MUC5B	114,119	mucin	MUC5B	100508689	727897	Gene	Gene	genes|compound|START_ENTITY Up-regulation|nmod|genes Up-regulation|nmod|END_ENTITY	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric_otitis media with effusion .
9422745	0	mucin	6,11	MUC5B	44,49	mucin	MUC5B	100508689	727897	Gene	Gene	START_ENTITY|ccomp|express express|nsubj|genes genes|nummod|END_ENTITY	Human mucin genes MUC2 , MUC3 , MUC4 , MUC5AC , MUC5B , and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism .
10209489	0	mucin	19,24	MUC6	4,8	mucin	MUC6	100508689	4588	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues .
21851820	0	mucin	5,10	MUC6	0,4	mucin	MUC6	100508689	4588	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	MUC6 mucin expression inhibits tumor cell invasion .
10372967	0	mucin	37,42	MUC7	32,36	mucin	MUC7	100508689	4589	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	In-situ hybridization localized MUC7 mucin gene expression to the mucous acinar cells of human and MUC7-transgenic mouse salivary glands .
10642514	0	mucin	52,57	MUC7	63,67	mucin	MUC7	100508689	4589	Gene	Gene	MG2|compound|START_ENTITY MG2|appos|END_ENTITY	The recombinant N-terminal region of human salivary mucin MG2 -LRB- MUC7 -RRB- contains a binding domain for oral Streptococci and exhibits candidacidal activity .
14508262	0	mucin	70,75	MUC7	65,69	mucin	MUC7	100508689	4589	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Human epithelium from conjunctival impression cytology expresses MUC7 mucin gene .
16203048	0	mucin	38,43	MUC7	44,48	mucin	MUC7	100508689	4589	Gene	Gene	interactions|compound|START_ENTITY interactions|compound|END_ENTITY	Two-hybrid analysis of human salivary mucin MUC7 interactions .
16514118	0	mucin	19,24	MUC7	14,18	mucin	MUC7	100508689	4589	Gene	Gene	START_ENTITY|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo .
16778149	0	mucin	34,39	MUC7	29,33	mucin	MUC7	100508689	4589	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Functional analysis of human MUC7 mucin gene 5 ' - flanking region in lung epithelial cells .
8838308	0	mucin	61,66	MUC7	73,77	mucin	MUC7	100508689	4589	Gene	Gene	gene|compound|START_ENTITY localization|nmod|gene END_ENTITY|nsubj|localization	Structure and chromosomal localization of the human salivary mucin gene , MUC7 .
9070607	0	mucin	36,41	MUC8	48,52	mucin	MUC8	100508689	100129528	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization of a human mucin gene -LRB- MUC8 -RRB- and cloning of the cDNA corresponding to the carboxy terminus .
8027037	0	mucin	62,67	MUC_2	56,61	mucin	MUC 2	65202(Tax:10116)	4583	Gene	Gene	homologue|compound|START_ENTITY homologue|compound|END_ENTITY	Molecular cloning of the amino-terminal region of a rat MUC_2 mucin gene homologue .
9370281	0	mucin	53,58	MUC_2	47,52	mucin	MUC 2	65202(Tax:10116)	24572(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Sp1 protein contributes to airway-specific rat MUC_2 mucin gene transcription .
26818658	0	mucin	23,28	MicroRNA_429	0,12	mucin	MicroRNA 429	100508689	723865(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA_429 regulates mucin gene expression and secretion in murine model of colitis .
19762846	0	mucin	78,83	Muc1	7,11	mucin	Muc1	404104(Tax:9913)	281333(Tax:9913)	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|nsubj|END_ENTITY	Bovine Muc1 is a highly polymorphic gene encoding an extensively glycosylated mucin that binds bacteria .
11278439	0	mucin	34,39	Muc13	0,5	mucin	Muc13	100508689	56667	Gene	Gene	expressed|nsubj|START_ENTITY expressed|advmod|END_ENTITY	Muc13 , a novel human cell surface mucin expressed by epithelial and hemopoietic cells .
16887038	0	mucin	16,21	Muc13	81,86	mucin	Muc13	423101(Tax:9031)	100859223	Gene	Gene	genes|compound|START_ENTITY inventory|nmod|genes shows|nsubj|inventory shows|ccomp|encoded encoded|nsubjpass|domain domain|nmod|END_ENTITY	An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins .
16887038	0	mucin	65,70	Muc13	81,86	mucin	Muc13	423101(Tax:9031)	100859223	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins .
7926500	0	mucin	69,74	Muc2	37,41	mucin	Muc2	100508689	4583	Gene	Gene	START_ENTITY|nsubj|Biosynthesis Biosynthesis|nmod|mucin mucin|dep|END_ENTITY	Biosynthesis of human colonic mucin : Muc2 is the prominent secretory mucin .
9245735	0	mucin	22,27	Muc5AC	15,21	mucin	Muc5AC	100508689	682837(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Cloning of rat Muc5AC mucin gene : comparison of its structure and tissue distribution to that of human and mouse homologues .
15361359	0	mucin	35,40	Muc5ac	28,34	mucin	Muc5ac	100508689	4586	Gene	Gene	production|compound|START_ENTITY production|amod|END_ENTITY	Effects of dexamethasone on Muc5ac mucin production by primary airway goblet cells .
25820562	0	mucin	7,12	Muc5ac	0,6	mucin	Muc5ac	100508689	682837(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Muc5ac mucin expression during rat skin development .
1787340	0	mucin	24,29	Muc_1	36,41	mucin	Muc 1	100508689	4582	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the human mucin gene , Muc_1 , in normal tissues and metastatic pancreatic_tumors .
8443822	0	mucin	99,104	Mucin	0,5	mucin	Mucin	100508689	100508689	Gene	Gene	gene|compound|START_ENTITY express|dobj|gene synthesis|acl:relcl|express synthesis|compound|END_ENTITY	Mucin synthesis and secretion in various human epithelial_cancer cell lines that express the MUC-1 mucin gene .
8838089	0	mucin	59,64	Mucin	1,6	mucin	Mucin	100508689	100508689	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulation|nmod|expression gene|dep|regulation gene|compound|END_ENTITY	-LSB- Mucin gene -- regulation of the expression of MUC2 and MUC3 mucin gene in the airway -RSB- .
16139976	0	mucin	21,26	P2Y2	0,4	mucin	P2Y2	100508689	5029	Gene	Gene	secretion|compound|START_ENTITY secretion|nummod|END_ENTITY	P2Y2 agonist induces mucin secretion via Ca2 + - _ and_inositol_1 ,4,5 - triphosphate-dependent pathway in human middle ear epithelial cells .
17555715	0	mucin	67,72	PAK2	18,22	mucin	PAK2	100508689	5062	Gene	Gene	roles|acl|START_ENTITY roles|nmod|END_ENTITY	Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF .
18055557	0	mucin	40,45	Protein_kinase_C_delta	0,22	mucin	Protein kinase C delta	100508689	5580	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Protein_kinase_C_delta regulates airway mucin secretion via phosphorylation of MARCKS protein .
23249391	0	mucin	49,54	TGF-b	0,5	mucin	TGF-b	100508689	7040	Gene	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	TGF-b decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells .
10728932	0	mucin	38,43	TNF-alpha	11,20	mucin	TNF-alpha	100508689	7124	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of TNF-alpha and IL-1_beta on mucin , lysozyme , IL-6 and IL-8 in passage-2 normal human nasal epithelial cells .
11052828	0	mucin	82,87	TNF-alpha	0,9	mucin	TNF-alpha	100508689	7124	Gene	Gene	hypersecretion|compound|START_ENTITY aspects|nmod|hypersecretion END_ENTITY|dep|aspects	TNF-alpha in the regulation of MUC5AC secretion : some aspects of cytokine-induced mucin hypersecretion on the in vitro model .
15466377	0	mucin	62,67	Transforming_growth_factor-beta2	0,32	mucin	Transforming growth factor-beta2	100508689	7042	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-beta2 induces bronchial epithelial mucin expression in asthma .
10030839	0	mucin	39,44	Tumor_necrosis_factor-alpha	0,27	mucin	Tumor necrosis factor-alpha	100508689	100135630(Tax:10141)	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Tumor_necrosis_factor-alpha stimulates mucin secretion and cyclic_GMP production by guinea_pig tracheal epithelial cells in vitro .
24916573	0	mucin	32,37	alpha-fetoprotein	51,68	mucin	alpha-fetoprotein	100508689	174	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	The adenocarcinoma cell surface mucin receptor for alpha-fetoprotein : is the same receptor present on circulating monocytes and macrophages ?
17446847	0	mucin	58,63	carcinoembryonic_antigen	13,37	mucin	carcinoembryonic antigen	100508689	1084	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	The level of carcinoembryonic_antigen and the presence of mucin as predictors of cystic pancreatic mucinous_neoplasia .
16007204	0	mucin	34,39	interferon-gamma	48,64	mucin	interferon-gamma	100508689	3458	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Synergistic induction of the MUC4 mucin gene by interferon-gamma and retinoic_acid in human pancreatic_tumour cells involves a reprogramming of signalling pathways .
7842630	0	mucin	49,54	interferon-gamma	10,26	mucin	interferon-gamma	100508689	3458	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian_carcinoma cell lines .
21868713	0	mucin	132,137	interleukin-6	100,113	mucin	interleukin-6	100508689	3569	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Epidermal_growth_factor_receptor signaling mediates vesicant-induced airway epithelial secretion of interleukin-6 and production of mucin .
25704757	0	mucin	36,41	matrix_metalloproteinase-9	56,82	mucin	matrix metalloproteinase-9	100508689	4318	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of high glucose-mediated mucin expression by matrix_metalloproteinase-9 in human airway epithelial cells .
8948445	0	mucin	116,121	mucin	15,20	mucin	mucin	100508689	100508689	Gene	Gene	epitopes|nmod|START_ENTITY dimerize|nmod|epitopes appears|xcomp|dimerize appears|nsubj|apoprotein apoprotein|compound|END_ENTITY	The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the ` insoluble ' mucin of rat small intestine .
8948445	0	mucin	15,20	mucin	116,121	mucin	mucin	100508689	100508689	Gene	Gene	apoprotein|compound|START_ENTITY appears|nsubj|apoprotein appears|xcomp|dimerize dimerize|nmod|epitopes epitopes|nmod|END_ENTITY	The human MUC2 mucin apoprotein appears to dimerize before O-glycosylation and shares epitopes with the ` insoluble ' mucin of rat small intestine .
9620876	0	mucin	134,139	mucin	58,63	mucin	mucin	100508689	100508689	Gene	Gene	family|compound|START_ENTITY gene|nmod|family evidence|nmod|gene organization|dep|evidence organization|dep|region region|nmod|gene gene|compound|END_ENTITY	Genomic organization of the 3 ' - region of the human MUC5AC mucin gene : additional evidence for a common ancestral gene for the 11p15 .5 mucin gene family .
9620876	0	mucin	58,63	mucin	134,139	mucin	mucin	100508689	100508689	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene organization|dep|region organization|dep|evidence evidence|nmod|gene gene|nmod|family family|compound|END_ENTITY	Genomic organization of the 3 ' - region of the human MUC5AC mucin gene : additional evidence for a common ancestral gene for the 11p15 .5 mucin gene family .
8947556	0	mucin	117,122	neurofascin	104,115	mucin	neurofascin	65202(Tax:10116)	116690(Tax:10116)	Gene	Gene	+|compound|START_ENTITY END_ENTITY|dep|+	Molecular composition of the node of Ranvier : identification of ankyrin-binding cell adhesion molecules neurofascin -LRB- mucin + / third FNIII domain - -RRB- and NrCAM at nodal axon segments .
15144402	0	mucin	12,17	p53	19,22	mucin	p53	4583	7157	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Analysis of mucin , p53 protein and Ki-67 expressions in gastric differentiated-type intramucosal neoplastic_lesions obtained from endoscopic mucosal resection samples : a proposal for a new classification of intramucosal neoplastic_lesions based on nuclear atypia .
10541345	0	mucin-1	11,18	MUC1	20,24	mucin-1	MUC1	4582	4582	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epithelial mucin-1 -LRB- MUC1 -RRB- expression and MA5 anti-MUC1 monoclonal antibody targeting in multiple myeloma .
26324125	0	mucin_1	17,24	miR-1291	0,8	mucin 1	miR-1291	4582	406917	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-1291 targets mucin_1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma .
26324125	0	mucin_1	17,24	miR-1291	0,8	mucin 1	miR-1291	4582	406917	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	miR-1291 targets mucin_1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma .
22028245	0	mucin_9	22,29	MUC9	31,35	mucin 9	MUC9	5016	5016	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of mucin_9 -LRB- MUC9 -RRB- in patients with ulcerative_colitis .
9688648	0	mucinlike_glycoprotein	30,52	MUCLIN	54,60	mucinlike glycoprotein	MUCLIN	12945(Tax:10090)	12945(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of a mucinlike_glycoprotein -LRB- MUCLIN -RRB- in pancreas and small intestine of CF mice .
23727036	0	mucosa-associated_lymphoid_tissue_1	13,48	MALT1	50,55	mucosa-associated lymphoid tissue 1	MALT1	10892	10892	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A homozygous mucosa-associated_lymphoid_tissue_1 -LRB- MALT1 -RRB- mutation in a family with combined_immunodeficiency .
22158899	0	mucosa-associated_lymphoid_tissue_lymphoma_translocation_1	25,83	MALT1	85,90	mucosa-associated lymphoid tissue lymphoma translocation 1	MALT1	10892	10892	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Crystal structure of the mucosa-associated_lymphoid_tissue_lymphoma_translocation_1 -LRB- MALT1 -RRB- paracaspase region .
15030510	0	mucosal_addressin_cell_adhesion_molecule-1	82,124	MAdCAM-1	126,134	mucosal addressin cell adhesion molecule-1	MAdCAM-1	17123(Tax:10090)	17123(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Blocking lymphotoxin-beta_receptor activation diminishes inflammation via reduced mucosal_addressin_cell_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- expression and leucocyte margination in chronic DSS-induced colitis .
15030510	0	mucosal_addressin_cell_adhesion_molecule-1	82,124	colitis	196,203	mucosal addressin cell adhesion molecule-1	LTbetaR	17123(Tax:10090)	17000(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Blocking lymphotoxin-beta_receptor activation diminishes inflammation via reduced mucosal_addressin_cell_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- expression and leucocyte margination in chronic DSS-induced colitis .
17202440	0	mucosal_addressin_cellular_adhesion_molecule-1	41,87	MAdCAM-1	89,97	mucosal addressin cellular adhesion molecule-1	MAdCAM-1	17123(Tax:10090)	17123(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Parenteral nutrition and fasting reduces mucosal_addressin_cellular_adhesion_molecule-1 -LRB- MAdCAM-1 -RRB- mRNA in Peyer 's patches of mice .
16978845	0	mucosal_pentraxin	22,39	Mptx	41,45	mucosal pentraxin	Mptx	289243(Tax:10116)	289243(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Complex regulation of mucosal_pentraxin -LRB- Mptx -RRB- revealed by discrete micro-anatomical locations in colon .
18507686	0	mucus_core_protein-2	63,83	Tumor_necrosis_factor-alpha	0,27	mucus core protein-2	Tumor necrosis factor-alpha	24572(Tax:10116)	24835(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces the aberrant expression of mucus_core_protein-2 in non-neoplastic biliary epithelial cells via the upregulation of CDX2 in chronic_cholangitis .
2653457	0	multi-CSF	80,89	IL-3	91,95	multi-CSF	IL-3	16187(Tax:10090)	16187(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nonneoplastic hematopoietic myeloproliferative_syndrome induced by dysregulated multi-CSF -LRB- IL-3 -RRB- expression .
23880463	0	multi-PDZ_domain_protein-1	4,30	MUPP-1	32,38	multi-PDZ domain protein-1	MUPP-1	8777	8777	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	The multi-PDZ_domain_protein-1 -LRB- MUPP-1 -RRB- expression regulates cellular levels of the PALS-1 / PATJ polarity complex .
12839333	0	multi-PDZ_domain_protein_1	25,51	Claudin-8	0,9	multi-PDZ domain protein 1	Claudin-8	8777	478401(Tax:9615)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Claudin-8 interacts with multi-PDZ_domain_protein_1 -LRB- MUPP1 -RRB- and reduces paracellular conductance in epithelial cells .
10806806	0	multi-drug_resistance_gene	18,44	MDR1	46,50	multi-drug resistance gene	MDR1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical study of multi-drug_resistance_gene -LRB- MDR1 -RRB- expression in primary ovarian_cancer .
7875611	0	multidrug-resistance	16,36	mdr1	10,14	multidrug-resistance	mdr1	5243	5243	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	The human mdr1 -LRB- multidrug-resistance -RRB- gene harbours a long homopyrimidine.homopurine sequence next to a cluster of Alu repeated sequences in intron 14 .
17997497	0	multidrug-resistance-associated_protein	19,58	ABCC2	65,70	multidrug-resistance-associated protein	ABCC2	8714	1244	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the multidrug-resistance-associated_protein gene -LRB- ABCC2 -RRB- variants with intrahepatic_cholestasis_of_pregnancy .
7591304	0	multidrug-resistance-associated_protein	31,70	MRP	72,75	multidrug-resistance-associated protein	MRP	8714	8714	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Preferential expression of the multidrug-resistance-associated_protein -LRB- MRP -RRB- in adenocarcinoma_of_the_lung .
7927879	0	multidrug-resistance-associated_protein	24,63	MRP	65,68	multidrug-resistance-associated protein	MRP	8714	8714	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Possible involvement of multidrug-resistance-associated_protein -LRB- MRP -RRB- gene expression in spontaneous drug resistance to vincristine , etoposide and adriamycin in human glioma cells .
11039467	0	multidrug-resistance_1	18,40	MDR1	42,46	multidrug-resistance 1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the multidrug-resistance_1 -LRB- MDR1 -RRB- gene and prognosis in human pancreatic_cancer .
9344662	0	multidrug-resistance_protein	54,82	MRP	89,92	multidrug-resistance protein	MRP	4363	4363	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the intron-exon organization of the human multidrug-resistance_protein gene -LRB- MRP -RRB- and alternative splicing of its mRNA .
10464142	0	multidrug-resistance_protein_2	38,68	MRP2	70,74	multidrug-resistance protein 2	MRP2	1244	1244	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exon-intron organization of the human multidrug-resistance_protein_2 -LRB- MRP2 -RRB- gene mutated in Dubin-Johnson_syndrome .
19124075	0	multidrug-resistance_protein_2	68,98	MRP2	100,104	multidrug-resistance protein 2	MRP2	1244	1244	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Support vector machine and pharmacophore-based prediction models of multidrug-resistance_protein_2 -LRB- MRP2 -RRB- inhibitors .
22722930	0	multidrug_and_toxin_extruder_1	74,104	MATE1	67,72	multidrug and toxin extruder 1	MATE1	55244	55244	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Twelve transmembrane helices form the functional core of mammalian MATE1 -LRB- multidrug_and_toxin_extruder_1 -RRB- protein .
22149660	0	multidrug_and_toxin_extrusion_1	21,52	MATE1	54,59	multidrug and toxin extrusion 1	MATE1	55244	55244	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of human multidrug_and_toxin_extrusion_1 -LRB- MATE1 -RRB- transporter with antineoplastic agents .
19332510	0	multidrug_and_toxin_extrusion_1	27,58	mate1	60,65	multidrug and toxin extrusion 1	mate1	67473(Tax:10090)	67473(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Targeted disruption of the multidrug_and_toxin_extrusion_1 -LRB- mate1 -RRB- gene in mice reduces renal secretion of metformin .
11426620	0	multidrug_resistance	34,54	MDR1	28,32	multidrug resistance	MDR1	5243	5243	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Differential effects of the MDR1 -LRB- multidrug_resistance -RRB- gene-activating agents on protein_kinase_C : evidence for redundancy of mechanisms of acquired MDR in leukemia cells .
11990778	0	multidrug_resistance	38,58	MDR1	60,64	multidrug resistance	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional polymorphisms of the human multidrug_resistance -LRB- MDR1 -RRB- gene : correlation with P_glycoprotein expression and activity in vivo .
1360648	0	multidrug_resistance	86,106	MDR1	108,112	multidrug resistance	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Purification and characterization of NF-R1 that regulates the expression of the human multidrug_resistance -LRB- MDR1 -RRB- gene .
17519790	0	multidrug_resistance	17,37	MDR1	44,48	multidrug resistance	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of multidrug_resistance gene -LRB- MDR1 -RRB- and cyclosporine absorption in de novo renal transplant patients .
1976252	0	multidrug_resistance	31,51	MDR1	25,29	multidrug resistance	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Quantitative analysis of MDR1 -LRB- multidrug_resistance -RRB- gene expression in human tumors by polymerase chain reaction .
7949467	0	multidrug_resistance	29,49	MDR1	51,55	multidrug resistance	MDR1	5243	5243	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Transactivation of the human multidrug_resistance -LRB- MDR1 -RRB- gene promoter by p53 mutants .
8098026	0	multidrug_resistance	86,106	MDR1	108,112	multidrug resistance	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Purification and characterization of NF-R2 that regulates the expression of the human multidrug_resistance -LRB- MDR1 -RRB- gene .
8387754	0	multidrug_resistance	19,39	MDR1	13,17	multidrug resistance	MDR1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	-LSB- Analysis of MDR1 -LRB- multidrug_resistance -RRB- gene expression by RT-PCR -RSB- .
9375821	0	multidrug_resistance	20,40	MDR1	14,18	multidrug resistance	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Expression of MDR1 -LRB- multidrug_resistance -RRB- gene and its protein in normal human kidney .
9384659	0	multidrug_resistance	22,42	MDR1	16,20	multidrug resistance	MDR1	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transfer of the MDR1 -LRB- multidrug_resistance -RRB- gene : protection of hematopoietic cells from cytotoxic chemotherapy , and selection of transduced cells in vivo .
8678896	0	multidrug_resistance	75,95	Mdr1	97,101	multidrug resistance	Mdr1	5243	5243	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Expression of the low-density_lipoprotein_receptor , HMG-CoA_reductase , and multidrug_resistance -LRB- Mdr1 -RRB- genes in colorectal_carcinomas .
8587143	0	multidrug_resistance	74,94	mdr1	68,72	multidrug resistance	mdr1	5243	5243	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Repetitive DNA sequences located in the central region of the human mdr1 -LRB- multidrug_resistance -RRB- gene may account for a gene fusion event during its evolution .
7949467	0	multidrug_resistance	29,49	p53	74,77	multidrug resistance	p53	5243	7157	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Transactivation of the human multidrug_resistance -LRB- MDR1 -RRB- gene promoter by p53 mutants .
15507937	0	multidrug_resistance-1	168,190	MDR-1	192,197	multidrug resistance-1	MDR-1	5243	5243	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Internalization of cytotoxic analog AN-152 of luteinizing_hormone-releasing_hormone induces apoptosis in human endometrial_and_ovarian_cancer cell lines independent of multidrug_resistance-1 -LRB- MDR-1 -RRB- system .
15081455	0	multidrug_resistance-1	21,43	MDR1	45,49	multidrug resistance-1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the multidrug_resistance-1 -LRB- MDR1 -RRB- gene influence the response to atorvastatin treatment in a gender-specific manner .
15569157	0	multidrug_resistance-1	30,52	interleukin-2	61,74	multidrug resistance-1	interleukin-2	5243	3558	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of multidrug_resistance-1 gene by interleukin-2 in lymphocytes .
21584513	0	multidrug_resistance-1	24,46	mdr1	48,52	multidrug resistance-1	mdr1	5243	5243	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Activation of the human multidrug_resistance-1 -LRB- mdr1 -RRB- gene promoter in response to inhibitors of DNA topoisomerases .
10024690	0	multidrug_resistance-associated_protein	33,72	Dihydropyrimidine_dehydrogenase	0,31	multidrug resistance-associated protein	Dihydropyrimidine dehydrogenase	8714	1806	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Dihydropyrimidine_dehydrogenase , multidrug_resistance-associated_protein , and thymidylate_synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal_cancer cells .
10213370	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of multidrug_resistance-associated_protein -LRB- MRP -RRB- functional activity with pluronic block copolymers .
10330452	0	multidrug_resistance-associated_protein	36,75	MRP	77,80	multidrug resistance-associated protein	MRP	17250(Tax:10090)	17250(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Tissue and cell distribution of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in mouse intestine and kidney .
10408915	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of multidrug_resistance-associated_protein -LRB- MRP -RRB- activity by rifampicin in human multidrug-resistant lung_tumor cells .
11206006	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in human gliomas .
7656221	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in thyroid_cancers .
7803281	0	multidrug_resistance-associated_protein	23,62	MRP	64,67	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in chronic_and_prolymphocytic_leukaemia .
7808005	0	multidrug_resistance-associated_protein	18,57	MRP	59,62	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in acute leukaemia .
7911548	0	multidrug_resistance-associated_protein	18,57	MRP	59,62	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in acute_and_chronic_leukemias .
7914828	0	multidrug_resistance-associated_protein	32,71	MRP	72,75	multidrug resistance-associated protein	MRP	24565(Tax:10116)	24565(Tax:10116)	Gene	Gene	detection|nmod|START_ENTITY END_ENTITY|nsubj|detection	Immunochemical detection of the multidrug_resistance-associated_protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies .
7923112	0	multidrug_resistance-associated_protein	18,57	MRP	59,62	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma .
8050090	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in anaplastic_carcinoma of the thyroid .
8062263	0	multidrug_resistance-associated_protein	12,51	MRP	53,56	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of multidrug_resistance-associated_protein -LRB- MRP -RRB- messenger RNA in normal and malignant hematopoietic cells .
8275468	0	multidrug_resistance-associated_protein	18,57	MRP	59,62	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of multidrug_resistance-associated_protein -LRB- MRP -RRB- increases resistance to natural product drugs .
8558937	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- mRNA in blast cells from acute_myeloid_leukemia -LRB- AML -RRB- patients .
8605104	0	multidrug_resistance-associated_protein	33,72	MRP	74,77	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alterations in expression of the multidrug_resistance-associated_protein -LRB- MRP -RRB- gene in high-grade transitional_cell_carcinoma of the bladder .
8612802	0	multidrug_resistance-associated_protein	28,67	MRP	69,72	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Transport properties of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in human tumour cells .
8947528	0	multidrug_resistance-associated_protein	18,57	MRP	59,62	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in pancreatic_adenocarcinoma cell lines .
9096673	0	multidrug_resistance-associated_protein	21,60	MRP	62,65	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Possible role of the multidrug_resistance-associated_protein -LRB- MRP -RRB- in chemoresistance of human melanoma cells .
9147606	0	multidrug_resistance-associated_protein	12,51	MRP	53,56	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The role of multidrug_resistance-associated_protein -LRB- MRP -RRB- expression in multidrug resistance .
9500978	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in brain microvessel endothelial cells .
9563653	0	multidrug_resistance-associated_protein	14,53	MRP	55,58	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance-associated_protein -LRB- MRP -RRB- in head_and_neck_squamous_cell_carcinoma .
9666517	0	multidrug_resistance-associated_protein	39,78	MRP	80,83	multidrug resistance-associated protein	MRP	8714	8714	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical significance of the increased multidrug_resistance-associated_protein -LRB- MRP -RRB- gene expression in patients with primary breast_cancer .
10025956	0	multidrug_resistance-associated_protein	22,61	MRP1	63,67	multidrug resistance-associated protein	MRP1	8714	8714	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the multidrug_resistance-associated_protein -LRB- MRP1 -RRB- in human heavy metal-selected tumor cells .
11745741	0	multidrug_resistance-associated_protein	45,84	MRP1	86,90	multidrug resistance-associated protein	MRP1	8714	8714	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ritonavir induces P-glycoprotein expression , multidrug_resistance-associated_protein -LRB- MRP1 -RRB- expression , and drug transporter-mediated activity in a human intestinal cell line .
19306688	0	multidrug_resistance-associated_protein	25,64	MRP1	66,70	multidrug resistance-associated protein	MRP1	4363	4363	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Expression inhibition of multidrug_resistance-associated_protein -LRB- MRP1 -RRB- by multi-ribozyme expression system in HEK293 cells .
9270026	0	multidrug_resistance-associated_protein	80,119	MRP1	126,130	multidrug resistance-associated protein	MRP1	8714	4363	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of expression of cMOAT -LRB- MRP2 -RRB- , MRP3 , MRP4 , and MRP5 , homologues of the multidrug_resistance-associated_protein gene -LRB- MRP1 -RRB- , in human cancer cell lines .
9710742	0	multidrug_resistance-associated_protein	19,58	basic_fibroblast_growth_factor	68,98	multidrug resistance-associated protein	basic fibroblast growth factor	8714	2247	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	A possible role of multidrug_resistance-associated_protein -LRB- MRP -RRB- in basic_fibroblast_growth_factor secretion by AIDS-associated Kaposi 's _ sarcoma cells : a survival molecule ?
9824653	0	multidrug_resistance-associated_protein	20,59	basic_fibroblast_growth_factor	80,110	multidrug resistance-associated protein	basic fibroblast growth factor	8714	2247	Gene	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|nmod|END_ENTITY	A possible role for multidrug_resistance-associated_protein in the secretion of basic_fibroblast_growth_factor by osteogenic_sarcoma cell line -LRB- MG-63 -RRB- .
12475404	0	multidrug_resistance-associated_protein	78,117	mdr1	66,70	multidrug resistance-associated protein	mdr1	8714	5243	Gene	Gene	mRNA|appos|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Correlation of expression levels of multidrug_resistance_gene_1 -LRB- mdr1 -RRB- mRNA , multidrug_resistance-associated_protein -LRB- MRP -RRB- , amd P-glycoprotein -LRB- P-gp -RRB- with chemotherapy efficacy in malignant_lymphomas -RSB- .
11798719	0	multidrug_resistance-associated_protein	74,113	mrp	120,123	multidrug resistance-associated protein	mrp	8714	4363	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The clinical significance of lung_resistance-related_protein gene -LRB- lrp -RRB- , multidrug_resistance-associated_protein gene -LRB- mrp -RRB- and mdr-1 / p170 expression in acute_leukemia -RSB- .
12475404	0	multidrug_resistance-associated_protein	78,117	multidrug_resistance_gene_1	37,64	multidrug resistance-associated protein	multidrug resistance gene 1	8714	5243	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Correlation of expression levels of multidrug_resistance_gene_1 -LRB- mdr1 -RRB- mRNA , multidrug_resistance-associated_protein -LRB- MRP -RRB- , amd P-glycoprotein -LRB- P-gp -RRB- with chemotherapy efficacy in malignant_lymphomas -RSB- .
11706036	0	multidrug_resistance-associated_protein_2	14,55	ABCC2	57,62	multidrug resistance-associated protein 2	ABCC2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of multidrug_resistance-associated_protein_2 -LRB- ABCC2 -RRB- by the nuclear receptors pregnane_X_receptor , farnesoid_X-activated_receptor , and constitutive_androstane_receptor .
17047488	0	multidrug_resistance-associated_protein_2	58,99	ABCC2	39,44	multidrug resistance-associated protein 2	ABCC2	1244	1244	Gene	Gene	expression|amod|START_ENTITY Association|nmod|expression Association|nmod|END_ENTITY	Association of genetic polymorphism in ABCC2 with hepatic multidrug_resistance-associated_protein_2 expression and pravastatin pharmacokinetics .
16537972	0	multidrug_resistance-associated_protein_2	31,72	Abcc2	74,79	multidrug resistance-associated protein 2	Abcc2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Hormonal regulation of hepatic multidrug_resistance-associated_protein_2 -LRB- Abcc2 -RRB- primarily involves the pattern of growth_hormone secretion .
11408547	0	multidrug_resistance-associated_protein_2	34,75	MRP2	77,81	multidrug resistance-associated protein 2	MRP2	25303(Tax:10116)	25303(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Arsenic induces expression of the multidrug_resistance-associated_protein_2 -LRB- MRP2 -RRB- gene in primary rat and human hepatocytes .
12121239	0	multidrug_resistance-associated_protein_2	14,55	MRP2	57,61	multidrug resistance-associated protein 2	MRP2	1244	1244	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance-associated_protein_2 -LRB- MRP2 -RRB- in normal human tissues and carcinomas using tissue microarrays .
15507541	0	multidrug_resistance-associated_protein_2	27,68	Mrp2	70,74	multidrug resistance-associated protein 2	Mrp2	403632(Tax:9615)	403632(Tax:9615)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Functional analysis of dog multidrug_resistance-associated_protein_2 -LRB- Mrp2 -RRB- in comparison with rat Mrp2 .
16672223	0	multidrug_resistance-associated_protein_2	23,64	aquaglyceroporin_3	91,109	multidrug resistance-associated protein 2	aquaglyceroporin 3	1244	360	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Enhanced expression of multidrug_resistance-associated_protein_2 and reduced expression of aquaglyceroporin_3 in an arsenic-resistant human cell line .
11706036	0	multidrug_resistance-associated_protein_2	14,55	pregnane_X_receptor	89,108	multidrug resistance-associated protein 2	pregnane X receptor	25303(Tax:10116)	84385(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of multidrug_resistance-associated_protein_2 -LRB- ABCC2 -RRB- by the nuclear receptors pregnane_X_receptor , farnesoid_X-activated_receptor , and constitutive_androstane_receptor .
22411990	0	multidrug_resistance-associated_protein_4	32,73	Sorting_nexin_27	0,16	multidrug resistance-associated protein 4	Sorting nexin 27	10257	81609	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sorting_nexin_27 interacts with multidrug_resistance-associated_protein_4 -LRB- MRP4 -RRB- and mediates internalization of MRP4 .
8534927	0	multidrug_resistance-related_protein	80,116	MRP	118,121	multidrug resistance-related protein	MRP	84798	84798	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Difloxacin reverses multidrug resistance in HL-60 / AR cells that overexpress the multidrug_resistance-related_protein -LRB- MRP -RRB- gene .
20699370	0	multidrug_resistance_1	15,37	CDX2	0,4	multidrug resistance 1	CDX2	5243	1045	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CDX2 regulates multidrug_resistance_1 gene expression in malignant intestinal epithelium .
27060927	0	multidrug_resistance_1	14,36	CDX2	51,55	multidrug resistance 1	CDX2	5243	1045	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of multidrug_resistance_1 expression by CDX2 in ovarian_mucinous_adenocarcinoma .
10933203	0	multidrug_resistance_1	80,102	MDR1	109,113	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical scale production of an improved retroviral vector expressing the human multidrug_resistance_1 gene -LRB- MDR1 -RRB- .
15115917	0	multidrug_resistance_1	102,124	MDR1	131,135	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug_resistance_1 gene -LRB- MDR1 , ABCB1 -RRB- .
15505619	0	multidrug_resistance_1	17,39	MDR1	41,45	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in multidrug_resistance_1 -LRB- MDR1 -RRB- gene are associated with refractory Crohn_disease and ulcerative_colitis .
17118775	0	multidrug_resistance_1	26,48	MDR1	50,54	multidrug resistance 1	MDR1	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chemoprotection effect of multidrug_resistance_1 -LRB- MDR1 -RRB- gene transfer to hematopoietic progenitor cells and engrafted in mice with cancer allows intensified chemotherapy .
17568669	0	multidrug_resistance_1	28,50	MDR1	52,56	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulatory polymorphisms of multidrug_resistance_1 -LRB- MDR1 -RRB- gene are associated with the development of childhood acute_lymphoblastic_leukemia .
19250544	0	multidrug_resistance_1	4,26	MDR1	28,32	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The multidrug_resistance_1 -LRB- MDR1 -RRB- gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal_adenoma and colorectal_cancer ; a case control study .
19331170	0	multidrug_resistance_1	34,56	MDR1	58,62	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effect of promoter methylation of multidrug_resistance_1 -LRB- MDR1 -RRB- gene in gastric_carcinogenesis .
20840328	0	multidrug_resistance_1	57,79	MDR1	81,85	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of steroid_and_xenobiotic_receptor -LRB- SXR -RRB- and multidrug_resistance_1 -LRB- MDR1 -RRB- gene expression with survival among patients with invasive bladder_carcinoma .
25544376	0	multidrug_resistance_1	31,53	MDR1	55,59	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Differential expression of the multidrug_resistance_1 -LRB- MDR1 -RRB- protein in prostate_cancer cells is independent from anticancer drug treatment and Y_box_binding_protein_1 -LRB- YB-1 -RRB- activity .
9292393	0	multidrug_resistance_1	31,53	MDR1	55,59	multidrug resistance 1	MDR1	5243	5243	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Quantitative analysis of human multidrug_resistance_1 -LRB- MDR1 -RRB- gene expression by nonisotopic competitive reverse transcriptase polymerase chain reaction assay .
10816597	0	multidrug_resistance_1	14,36	heat-shock_transcription_factor_1	91,124	multidrug resistance 1	heat-shock transcription factor 1	5243	3297	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|nmod|END_ENTITY	Regulation of multidrug_resistance_1 -LRB- MDR1 -RRB- / P-glycoprotein gene expression and activity by heat-shock_transcription_factor_1 -LRB- HSF1 -RRB- .
23562850	0	multidrug_resistance_1	109,131	steroid_and_xenobiotic_receptor	74,105	multidrug resistance 1	steroid and xenobiotic receptor	5243	8856	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Interaction of silencing mediator for retinoid and thyroid receptors with steroid_and_xenobiotic_receptor on multidrug_resistance_1 promoter .
12381268	0	multidrug_resistance_2	84,106	Mdr2	108,112	multidrug resistance 2	Mdr2	18670(Tax:10090)	18670(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- - mediated regulation of multidrug_resistance_2 -LRB- Mdr2 -RRB- expression and function in mice .
10915741	0	multidrug_resistance_2	14,36	P-glycoprotein	37,51	multidrug resistance 2	P-glycoprotein	24891(Tax:10116)	287115(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of multidrug_resistance_2 P-glycoprotein expression by bile_salts in rats and in primary cultures of rat hepatocytes .
15203080	0	multidrug_resistance_P-glycoprotein_3	34,71	ABCB4	73,78	multidrug resistance P-glycoprotein 3	ABCB4	5244	5244	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations identified in the human multidrug_resistance_P-glycoprotein_3 -LRB- ABCB4 -RRB- gene in patients with primary hepatolithiasis .
18003156	0	multidrug_resistance_associated_protein	44,83	MRP	85,88	multidrug resistance associated protein	MRP	8714	8714	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Poly -LRB- Ethylene_Glycol -RRB- hydrogels as possible multidrug_resistance_associated_protein -LRB- MRP -RRB- inhibitors .
19323627	0	multidrug_resistance_associated_protein_5	14,55	MRP5	57,61	multidrug resistance associated protein 5	MRP5	10057	10057	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance_associated_protein_5 -LRB- MRP5 -RRB- on cornea and its role in drug efflux .
11254880	0	multidrug_resistance_associated_transporters	14,58	MDR1	60,64	multidrug resistance associated transporters	MDR1	5243	5243	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance_associated_transporters -LRB- MDR1 , MRP1 , LRP and BCRP -RRB- in porcine oocyte .
1349537	0	multidrug_resistance_gene	58,83	MDR1	85,89	multidrug resistance gene	MDR1	5243	5243	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Quercetin , a bioflavonoid , inhibits the increase of human multidrug_resistance_gene -LRB- MDR1 -RRB- expression caused by arsenite .
23876050	0	multidrug_resistance_gene	29,54	MDR1	56,60	multidrug resistance gene	MDR1	5243	5243	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Small molecule inhibitors of multidrug_resistance_gene -LRB- MDR1 -RRB- expression : preclinical evaluation and mechanisms of action .
7912240	0	multidrug_resistance_gene	18,43	MDR1	45,49	multidrug resistance gene	MDR1	5243	5243	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the multidrug_resistance_gene -LRB- MDR1 -RRB- in non-small cell lung_cancer .
1974900	0	multidrug_resistance_gene	18,43	P-glycoprotein	53,67	multidrug resistance gene	P-glycoprotein	5243	5243	Gene	Gene	product|amod|START_ENTITY Expression|nmod|product Expression|appos|END_ENTITY	Expression of the multidrug_resistance_gene product -LRB- P-glycoprotein -RRB- in human normal and tumor tissues .
1363104	0	multidrug_resistance_gene_1	40,67	P-glycoprotein	77,91	multidrug resistance gene 1	P-glycoprotein	5243	5243	Gene	Gene	product|amod|START_ENTITY expression|nmod|product expression|appos|END_ENTITY	Preferential expression and activity of multidrug_resistance_gene_1 product -LRB- P-glycoprotein -RRB- , a functionally active efflux pump , in human CD8 + T cells : a role in cytotoxic effector function .
12475404	0	multidrug_resistance_gene_1	37,64	mdr1	66,70	multidrug resistance gene 1	mdr1	5243	5243	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Correlation of expression levels of multidrug_resistance_gene_1 -LRB- mdr1 -RRB- mRNA , multidrug_resistance-associated_protein -LRB- MRP -RRB- , amd P-glycoprotein -LRB- P-gp -RRB- with chemotherapy efficacy in malignant_lymphomas -RSB- .
12475404	0	multidrug_resistance_gene_1	37,64	multidrug_resistance-associated_protein	78,117	multidrug resistance gene 1	multidrug resistance-associated protein	5243	8714	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	-LSB- Correlation of expression levels of multidrug_resistance_gene_1 -LRB- mdr1 -RRB- mRNA , multidrug_resistance-associated_protein -LRB- MRP -RRB- , amd P-glycoprotein -LRB- P-gp -RRB- with chemotherapy efficacy in malignant_lymphomas -RSB- .
10220571	0	multidrug_resistance_protein	48,76	CPT-11	24,30	multidrug resistance protein	CPT-11	4363	963084(Tax:115711)	Gene	Gene	efflux|nmod|START_ENTITY efflux|nmod|END_ENTITY	ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug_resistance_protein -LRB- MRP -RRB- and its inhibition by PAK-104P .
8831715	0	multidrug_resistance_protein	37,65	MRP	67,70	multidrug resistance protein	MRP	4363	4363	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multidrug resistance mediated by the multidrug_resistance_protein -LRB- MRP -RRB- gene .
8926361	0	multidrug_resistance_protein	8,36	MRP	38,41	multidrug resistance protein	MRP	4363	4363	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of multidrug_resistance_protein -LRB- MRP -RRB- in glutathione_S-conjugate transport in mammalian cells .
9187270	0	multidrug_resistance_protein	93,121	MRP	123,126	multidrug resistance protein	MRP	4363	4363	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	ATP-dependent transport of aflatoxin_B1 and its glutathione conjugates by the product of the multidrug_resistance_protein -LRB- MRP -RRB- gene .
9393741	0	multidrug_resistance_protein	30,58	MRP	25,28	multidrug resistance protein	MRP	17250(Tax:10090)	17250(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Disruption of the murine MRP -LRB- multidrug_resistance_protein -RRB- gene leads to increased sensitivity to etoposide -LRB- VP-16 -RRB- and increased levels of glutathione .
9624242	0	multidrug_resistance_protein	18,46	MRP	48,51	multidrug resistance protein	MRP	4363	4363	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the multidrug_resistance_protein -LRB- MRP -RRB- in squamous_cell_carcinoma_of_the_oesophagus and response to pre-operative chemotherapy .
10697508	0	multidrug_resistance_protein	18,46	MRP1	48,52	multidrug resistance protein	MRP1	4363	4363	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the multidrug_resistance_protein -LRB- MRP1 -RRB- in breast_cancer .
10791901	0	multidrug_resistance_protein	51,79	MRP1	88,92	multidrug resistance protein	MRP1	4363	4363	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Retroviral-mediated transfer and expression of the multidrug_resistance_protein 1 gene -LRB- MRP1 -RRB- protect human hematopoietic cells from antineoplastic drugs .
10828037	0	multidrug_resistance_protein	16,44	MRP1	45,49	multidrug resistance protein	MRP1	4363	4363	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Deletion of the multidrug_resistance_protein MRP1 gene in acute_myeloid_leukemia : the impact on MRP activity .
11467849	0	multidrug_resistance_protein	103,131	MRP1	133,137	multidrug resistance protein	MRP1	4363	4363	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of DNA-protein interactions in the 5 ' flanking and 5 ' untranslated regions of the human multidrug_resistance_protein -LRB- MRP1 -RRB- gene : evaluation of a putative antioxidant response element/AP -1 binding site .
10082567	0	multidrug_resistance_protein	113,141	Yor1p	81,86	multidrug resistance protein	Yor1p	4363	853198(Tax:4932)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Mutational disruption of plasma membrane trafficking of Saccharomyces_cerevisiae Yor1p , a homologue of mammalian multidrug_resistance_protein .
20206183	0	multidrug_resistance_protein-1	12,42	MRP1	44,48	multidrug resistance protein-1	MRP1	18669(Tax:10090)	18669(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the multidrug_resistance_protein-1 -LRB- MRP1 -RRB- for endothelial progenitor cell function and survival .
16621983	0	multidrug_resistance_protein_1	24,54	ABCC1	56,61	multidrug resistance protein 1	ABCC1	18669(Tax:10090)	17250(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dendritic_cells require multidrug_resistance_protein_1 -LRB- ABCC1 -RRB- transporter activity for differentiation .
11259786	0	multidrug_resistance_protein_1	14,44	MRP1	46,50	multidrug resistance protein 1	MRP1	24565(Tax:10116)	24565(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of multidrug_resistance_protein_1 -LRB- MRP1 -RRB- in the rat cochlea with special reference to the blood-inner ear barrier .
12391280	0	multidrug_resistance_protein_1	18,48	MRP1	50,54	multidrug resistance protein 1	MRP1	4363	4363	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of the multidrug_resistance_protein_1 -LRB- MRP1 -RRB- by peptidomimetic glutathione-conjugate analogs .
10691972	0	multidrug_resistance_protein_2	56,86	MRP2	88,92	multidrug resistance protein 2	MRP2	1244	1244	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the 5 ' - flanking region of the human multidrug_resistance_protein_2 -LRB- MRP2 -RRB- gene and its regulation in comparison withthe multidrug_resistance_protein_3 -LRB- MRP3 -RRB- gene .
11682439	0	multidrug_resistance_protein_2	8,38	MRP2	40,44	multidrug resistance protein 2	MRP2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of multidrug_resistance_protein_2 -LRB- MRP2 -RRB- in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells .
14569069	0	multidrug_resistance_protein_2	8,38	MRP2	40,44	multidrug resistance protein 2	MRP2	1244	1244	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of multidrug_resistance_protein_2 -LRB- MRP2 , ABCC2 -RRB- in alkylating agent detoxification : MRP2 potentiates glutathione_S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity .
15519272	0	multidrug_resistance_protein_2	25,55	MRP2	57,61	multidrug resistance protein 2	MRP2	1244	1244	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the multidrug_resistance_protein_2 -LRB- MRP2 -RRB- gene in a Japanese patient with Dubin-Johnson_syndrome .
21206495	0	multidrug_resistance_protein_2	8,38	MRP2	40,44	multidrug resistance protein 2	MRP2	1244	1244	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of multidrug_resistance_protein_2 -LRB- MRP2 -RRB- in chemoresistance and clinical outcome in oesophageal_squamous_cell_carcinoma .
23612356	0	multidrug_resistance_protein_2	14,44	MRP2	46,50	multidrug resistance protein 2	MRP2	1244	1244	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of multidrug_resistance_protein_2 -LRB- MRP2 , ABCC2 -RRB- expression by statins : involvement of SREBP-mediated gene regulation .
9571149	0	multidrug_resistance_protein_2	87,117	mrp2	119,123	multidrug resistance protein 2	mrp2	24891(Tax:10116)	24891(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence analysis and functional characterization of the 5 ' - flanking region of the rat multidrug_resistance_protein_2 -LRB- mrp2 -RRB- gene .
10691972	0	multidrug_resistance_protein_3	140,170	MRP3	172,176	multidrug resistance protein 3	MRP3	5244	5244	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Characterization of the 5 ' - flanking region of the human multidrug_resistance_protein_2 -LRB- MRP2 -RRB- gene and its regulation in comparison withthe multidrug_resistance_protein_3 -LRB- MRP3 -RRB- gene .
11481620	0	multidrug_resistance_protein_3	29,59	Mrp3	61,65	multidrug resistance protein 3	Mrp3	140668(Tax:10116)	140668(Tax:10116)	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of basolateral multidrug_resistance_protein_3 -LRB- Mrp3 -RRB- in cholestatic rat liver .
18625884	0	multidrug_resistance_protein_4	11,41	MRP4	43,47	multidrug resistance protein 4	MRP4	10257	10257	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for multidrug_resistance_protein_4 -LRB- MRP4 ; ABCC4 -RRB- in human dendritic cell migration .
12564036	0	multidrug_resistant-associated_protein_gene	40,83	MRP	85,88	multidrug resistant-associated protein gene	MRP	4363	4363	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression and clinical implication of multidrug_resistant-associated_protein_gene -LRB- MRP -RRB- in patients with laryngeal_squamous_cell_carcinoma -RSB- .
22363234	0	multiple_drug_resistance_1	73,99	MDR1	101,105	multiple drug resistance 1	MDR1	5243	5243	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
9922473	0	multiple_endocrine_neoplasia_type-1	51,86	MEN-1	88,93	multiple endocrine neoplasia type-1	MEN-1	4221	4221	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Molecular diagnosis in an Argentinian family with multiple_endocrine_neoplasia_type-1 -LRB- MEN-1 -RRB- -RSB- .
8099302	0	multiple_endocrine_neoplasia_type_1	24,59	FAU	13,16	multiple endocrine neoplasia type 1	FAU	4221	2197	Gene	Gene	_|amod|START_ENTITY END_ENTITY|nmod|_	Exclusion of FAU as the multiple_endocrine_neoplasia_type_1 _ -LRB- MEN1 -RRB- _ gene .
10576763	0	multiple_endocrine_neoplasia_type_1	58,93	MEN1	9,13	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	mutations|nmod|START_ENTITY mutations|nsubj|END_ENTITY	Germline MEN1 mutations in sixteen Japanese families with multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- .
10715991	0	multiple_endocrine_neoplasia_type_1	25,60	MEN1	62,66	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Somatic mutations of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene in patients with sporadic , nonfamilial primary_hyperparathyroidism .
12941803	0	multiple_endocrine_neoplasia_type_1	46,81	MEN1	83,87	multiple endocrine neoplasia type 1	MEN1	17283(Tax:10090)	17283(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pancreatic beta-cell-specific ablation of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene causes full penetrance of insulinoma development in mice .
15240620	0	multiple_endocrine_neoplasia_type_1	10,45	MEN1	47,51	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effect of multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene mutations on premature mortality in familial_MEN1_syndrome with founder mutations .
17188139	0	multiple_endocrine_neoplasia_type_1	59,94	MEN1	96,100	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Recognizing genes differentially regulated in vitro by the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene , using RNA interference and oligonucleotide microarrays .
17953629	0	multiple_endocrine_neoplasia_type_1	47,82	MEN1	0,4	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	MEN1 gene mutations in Hungarian patients with multiple_endocrine_neoplasia_type_1 .
9067266	0	multiple_endocrine_neoplasia_type_1	54,89	MEN1	91,95	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotype analysis defines a minimal interval for the multiple_endocrine_neoplasia_type_1 _ -LRB- MEN1 -RRB- _ gene .
9205115	0	multiple_endocrine_neoplasia_type_1	29,64	MEN1	66,70	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	A 2.8-Mb clone contig of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- region at 11q13 .
9215690	0	multiple_endocrine_neoplasia_type_1	22,57	MEN1	59,63	multiple endocrine neoplasia type 1	MEN1	539431(Tax:9913)	539431(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene .
9286704	0	multiple_endocrine_neoplasia_type_1	84,119	MEN1	121,125	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene .
9385379	0	multiple_endocrine_neoplasia_type_1	40,75	MEN1	77,81	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Eighteen new polymorphic markers in the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- region .
9506756	0	multiple_endocrine_neoplasia_type_1	38,73	MEN1	75,79	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Absence of germ-line mutations of the multiple_endocrine_neoplasia_type_1 -LRB- MEN1 -RRB- gene in familial_pituitary_adenoma in contrast to MEN1 in Japanese .
9747036	0	multiple_endocrine_neoplasia_type_1	38,73	MEN1	6,10	multiple endocrine neoplasia type 1	MEN1	4221	4221	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Novel MEN1 gene mutations in familial multiple_endocrine_neoplasia_type_1 .
11446674	0	multiple_endocrine_neoplasia_type_1	38,73	MEN_1	75,80	multiple endocrine neoplasia type 1	MEN 1	4221	4221	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A germline mutation , 1001delC , of the multiple_endocrine_neoplasia_type_1 -LRB- MEN_1 -RRB- gene in a Japanese family .
9003511	0	multiple_endocrine_neoplasia_type_1	109,144	MEN_1	146,151	multiple endocrine neoplasia type 1	MEN 1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exclusion of the phosphatidylinositol-specific phospholipase C beta 3 -LRB- PLC_beta_3 -RRB- gene as candidate for the multiple_endocrine_neoplasia_type_1 -LRB- MEN_1 -RRB- gene .
9066984	0	multiple_endocrine_neoplasia_type_1	75,110	MEN_1	112,117	multiple endocrine neoplasia type 1	MEN 1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exclusion of the nuclear_factor-kappa_B3 -LRB- REL_A -RRB- gene as candidate for the multiple_endocrine_neoplasia_type_1 -LRB- MEN_1 -RRB- gene .
17766243	0	multiple_endocrine_neoplasia_type_1	51,86	caspase_8	15,24	multiple endocrine neoplasia type 1	caspase 8	17283(Tax:10090)	12370(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Menin-mediated caspase_8 expression in suppressing multiple_endocrine_neoplasia_type_1 .
17923033	0	multiple_endocrine_neoplasia_type_2A	56,92	MEN2A	94,99	multiple endocrine neoplasia type 2A	MEN2A	5979	5979	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- DelD631 : a novel mutation of the RET proto-oncogene in multiple_endocrine_neoplasia_type_2A -LRB- MEN2A -RRB- -RSB- .
16424056	0	multiple_endocrine_neoplasia_type_2A	77,113	RET	17,20	multiple endocrine neoplasia type 2A	RET	5979	5979	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms in RET and its coreceptors and ligands as genetic modifiers of multiple_endocrine_neoplasia_type_2A .
24169328	0	multiple_endocrine_neoplasia_type_2A	87,123	RET	27,30	multiple endocrine neoplasia type 2A	RET	5979	5979	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The clinical patterns and RET proto-oncogene identification of pheochromocytoma in 13 multiple_endocrine_neoplasia_type_2A pedigrees -RSB- .
9157974	0	multiple_endocrine_neoplasia_type_I	20,55	MEN1	57,61	multiple endocrine neoplasia type I	MEN1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the multiple_endocrine_neoplasia_type_I -LRB- MEN1 -RRB- gene based on tumor loss of heterozygosity analysis .
12210500	0	multiple_endocrine_neoplasm_type_1	37,71	MEN1	73,77	multiple endocrine neoplasm type 1	MEN1	4221	4221	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Determination of allelic deletion of multiple_endocrine_neoplasm_type_1 -LRB- MEN1 -RRB- gene in acute_myeloid_leukemia -LRB- AML -RRB- by application of FISH-TSA technique .
1541640	0	multiple_intestinal_neoplasia	9,38	Min	4,7	multiple intestinal neoplasia	Min	11789(Tax:10090)	11789(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The Min -LRB- multiple_intestinal_neoplasia -RRB- mutation : its effect on gut epithelial cell differentiation and interaction with a modifier system .
711693	0	multiplication-stimulating_activity	42,77	somatomedin	17,28	multiplication-stimulating activity	somatomedin	24483(Tax:10116)	100008668(Tax:9986)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Demonstration of somatomedin activity of `` multiplication-stimulating_activity '' in rabbit costal chondrocytes in culture .
12932699	0	multixenobiotic_resistance	126,152	p-glycoprotein	101,115	multixenobiotic resistance	p-glycoprotein	9429	5243	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Mussel blood cells , resistant to the cytotoxic effects of okadaic_acid , do not express cell membrane p-glycoprotein activity -LRB- multixenobiotic_resistance -RRB- .
18433484	0	murine_double_minute-2	65,87	MDM2	89,93	murine double minute-2	MDM2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Early onset lung_cancer , cigarette smoking and the SNP309 of the murine_double_minute-2 -LRB- MDM2 -RRB- gene .
26470726	0	murine_double_minute_2	57,79	Mdm2	81,85	murine double minute 2	Mdm2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Apoptosis of Sertoli cells after conditional ablation of murine_double_minute_2 -LRB- Mdm2 -RRB- gene is p53-dependent and results in male_sterility .
26854347	0	murine_double_minute_2	95,117	mdm2	119,123	murine double minute 2	mdm2	17246(Tax:10090)	17246(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The viral non-structural protein 1 alpha -LRB- Nsp1a -RRB- inhibits p53 apoptosis activity by increasing murine_double_minute_2 -LRB- mdm2 -RRB- expression in porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- early-infected cells .
8473484	0	muscarinic_M2_receptor	94,116	eosinophil_major_basic_protein	6,36	muscarinic M2 receptor	eosinophil major basic protein	1129	5553	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Human eosinophil_major_basic_protein is an endogenous allosteric antagonist at the inhibitory muscarinic_M2_receptor .
16007679	0	muscle-derived_protein_with_molecular_mass_of_77_kDa	21,73	MDP77	75,80	muscle-derived protein with molecular mass of 77 kDa	MDP77	167838	167838	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Long-term effects of muscle-derived_protein_with_molecular_mass_of_77_kDa -LRB- MDP77 -RRB- on nerve regeneration .
24001173	0	muscle-restricted_coiled-coil_protein	18,55	MURC	57,61	muscle-restricted coiled-coil protein	MURC	313225(Tax:10116)	313225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hypoxia activates muscle-restricted_coiled-coil_protein -LRB- MURC -RRB- expression via transforming growth factor-b in cardiac myocytes .
9016574	0	muscle-specific	14,29	Id3	49,52	muscle-specific	Id3	27335	3399	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of muscle-specific gene expression by Id3 : requirement of the C-terminal region of the protein for stable expression and function .
1840492	0	muscle-specific_enolase	33,56	ENO3	63,67	muscle-specific enolase	ENO3	2027	2027	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular structure of the human muscle-specific_enolase gene -LRB- ENO3 -RRB- .
10545043	0	muscle-specific_phosphoglycerate_mutase	76,115	PGAM-M	117,123	muscle-specific phosphoglycerate mutase	PGAM-M	5224	5224	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific_phosphoglycerate_mutase -LRB- PGAM-M -RRB- gene .
11002340	0	muscle-specific_protein	30,53	MSP	55,58	muscle-specific protein	MSP	259260(Tax:7955)	259260(Tax:7955)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Asynchronous activation of 10 muscle-specific_protein -LRB- MSP -RRB- genes during zebrafish somitogenesis .
16519896	0	muscle_LIM_protein	11,29	MLP	31,34	muscle LIM protein	MLP	117505(Tax:10116)	117505(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for muscle_LIM_protein -LRB- MLP -RRB- in vascular remodeling .
15205937	0	muscle_LIM_protein	33,51	N-RAP	63,68	muscle LIM protein	N-RAP	8048	4892	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Decreased interactions of mutant muscle_LIM_protein -LRB- MLP -RRB- with N-RAP and alpha-actinin and their implication for hypertrophic_cardiomyopathy .
4389002	0	muscle_activity_factor	14,36	MAF	38,41	muscle activity factor	MAF	4094	4094	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of muscle_activity_factor -LRB- MAF -RRB- on cardiac contractility and sugar transport .
18785187	0	muscle_atrophy_F-box	10,30	MAFbx	32,37	muscle atrophy F-box	MAFbx	67731(Tax:10090)	67731(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Decreased muscle_atrophy_F-box -LRB- MAFbx -RRB- expression in regenerating muscle after muscle-damaging exercise .
11861503	0	muscle_creatine_kinase	35,57	Akt1	0,4	muscle creatine kinase	Akt1	1158	207	Gene	Gene	transcription|amod|START_ENTITY regulate|dobj|transcription regulate|nsubj|END_ENTITY	Akt1 and Akt2 differently regulate muscle_creatine_kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts .
21686210	0	muscle_ring-finger-1	12,32	MURF1	34,39	muscle ring-finger-1	MURF1	433766(Tax:10090)	433766(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Rise above : muscle_ring-finger-1 -LRB- MURF1 -RRB- regulation of cardiomyocyte size and energy metabolism .
26667042	0	muscle_segment_homeobox	24,47	Msx	49,52	muscle segment homeobox	Msx	17701(Tax:10090)	17701(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Uterine inactivation of muscle_segment_homeobox -LRB- Msx -RRB- genes alters epithelial cell junction proteins during embryo implantation .
3122635	0	muscle_specific_carbonic_anhydrase	19,53	CAIII	55,60	muscle specific carbonic anhydrase	CAIII	761	761	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for human muscle_specific_carbonic_anhydrase -LRB- CAIII -RRB- is assigned to chromosome 8 .
17950246	0	musclin	30,37	Foxo1	0,5	musclin	Foxo1	239790(Tax:10090)	56458(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Foxo1 represses expression of musclin , a skeletal muscle-derived secretory factor .
26449458	0	musclin	20,27	PERK	66,70	musclin	PERK	344901	9451	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|activation activation|nmod|END_ENTITY	Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes .
1382471	0	mushroom_bodies	59,74	rutabaga	42,50	mushroom bodies	rutabaga	40436(Tax:7227)	32406(Tax:7227)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Preferential expression of the Drosophila rutabaga gene in mushroom_bodies , neural centers for learning in insects .
10640805	0	muskelin	22,30	MKLN1	65,70	muskelin	MKLN1	4289	4289	Gene	Gene	START_ENTITY|nmod|gene gene|appos|END_ENTITY	cDNA cloning of human muskelin and localisation of the muskelin -LRB- MKLN1 -RRB- gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH .
10640805	0	muskelin	55,63	MKLN1	65,70	muskelin	MKLN1	4289	4289	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	cDNA cloning of human muskelin and localisation of the muskelin -LRB- MKLN1 -RRB- gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH .
10640805	0	muskelin	22,30	muskelin	55,63	muskelin	muskelin	4289	4289	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	cDNA cloning of human muskelin and localisation of the muskelin -LRB- MKLN1 -RRB- gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH .
10640805	0	muskelin	55,63	muskelin	22,30	muskelin	muskelin	4289	4289	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	cDNA cloning of human muskelin and localisation of the muskelin -LRB- MKLN1 -RRB- gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH .
9285782	0	mut	91,94	methylmalonyl-CoA_mutase	43,67	mut	methylmalonyl-CoA mutase	4594	4594	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Expression and kinetic characterization of methylmalonyl-CoA_mutase from patients with the mut - phenotype : evidence for naturally occurring interallelic complementation .
16256791	0	mutL_homolog_1	71,85	hMLH1	28,33	mutL homolog 1	hMLH1	4292	4292	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Promoter methylation of the hMLH1 gene and protein expression of human mutL_homolog_1 and human mutS_homolog_2 in resected esophageal_squamous_cell_carcinoma .
10449536	0	mutated_in_colorectal_cancer	21,49	MCC	16,19	mutated in colorectal cancer	MCC	328949(Tax:10090)	328949(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of MCC -LRB- mutated_in_colorectal_cancer -RRB- in various tissues of mice and its involvement in cell differentiation .
8251915	0	myc	12,15	BCR-ABL	37,44	myc	BCR-ABL	4609	25	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of myc in transformation by BCR-ABL .
8187765	0	myc	95,98	Cyclin_D1	0,9	myc	Cyclin D1	17869(Tax:10090)	12443(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY lymphomagenesis|nmod|gene lymphocyte|nmod|lymphomagenesis lymphocyte|nsubj|impedes impedes|amod|END_ENTITY	Cyclin_D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene .
8798704	0	myc	96,99	Eca39	119,124	myc	Eca39	4609	856615(Tax:4932)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Mitochondrial and cytosolic branched-chain amino_acid transaminases from yeast , homologs of the myc oncogene-regulated Eca39 protein .
20667914	0	myc	24,27	Hfp	0,3	myc	Hfp	31310(Tax:7227)	38173(Tax:7227)	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner .
2332674	0	myc	30,33	c-myc	40,45	myc	c-myc	4609	4609	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	-LSB- A study of amplifications of myc gene -LRB- c-myc and N-myc -RRB- in human ovarian_cancer -RSB- .
2657576	0	myc	67,70	myc	8,11	myc	myc	17869(Tax:10090)	17869(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Altered myc gene transcription and intron-induced stabilization of myc RNAs in two mouse plasmacytomas .
2657576	0	myc	8,11	myc	67,70	myc	myc	17869(Tax:10090)	17869(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Altered myc gene transcription and intron-induced stabilization of myc RNAs in two mouse plasmacytomas .
6196641	0	myelin-associated_glycoprotein	15,45	HNK-1	73,78	myelin-associated glycoprotein	HNK-1	4099	27087	Gene	Gene	Recognition|nmod|START_ENTITY Recognition|nmod|END_ENTITY	Recognition of myelin-associated_glycoprotein by the monoclonal antibody HNK-1 .
23132925	0	myelin-associated_glycoprotein	73,103	LDL_receptor-related_protein-1	0,30	myelin-associated glycoprotein	LDL receptor-related protein-1	4099	4035	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	LDL_receptor-related_protein-1 is a sialic-acid-independent receptor for myelin-associated_glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin .
9690744	0	myelin-associated_glycoprotein	20,50	MAG	52,55	myelin-associated glycoprotein	MAG	4099	4099	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of myelin-associated_glycoprotein -LRB- MAG -RRB- proteolysis in the human central nervous system .
17974963	0	myelin-associated_glycoprotein	31,61	MUC1	0,4	myelin-associated glycoprotein	MUC1	4099	4582	Gene	Gene	counter-receptor|nmod|START_ENTITY counter-receptor|nsubj|END_ENTITY	MUC1 is a counter-receptor for myelin-associated_glycoprotein -LRB- Siglec-4a -RRB- and their interaction contributes to adhesion in pancreatic_cancer perineural invasion .
10221670	0	myelin-associated_glycoprotein	30,60	Nerve_growth_factor	0,19	myelin-associated glycoprotein	Nerve growth factor	4099	4803	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Nerve_growth_factor modulates myelin-associated_glycoprotein binding to sensory neurons .
24191038	0	myelin-associated_glycoprotein	50,80	Very_large_G_protein-coupled_receptor_1	0,39	myelin-associated glycoprotein	Very large G protein-coupled receptor 1	17136(Tax:10090)	110789(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Very_large_G_protein-coupled_receptor_1 regulates myelin-associated_glycoprotein via Gas/Gaq-mediated protein kinases A/C .
1722413	0	myelin-associated_glycoprotein	19,49	interferon-gamma	70,86	myelin-associated glycoprotein	interferon-gamma	4099	3458	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Down-regulation of myelin-associated_glycoprotein on Schwann cells by interferon-gamma and tumor_necrosis_factor-alpha affects neurite outgrowth .
12558973	0	myelin-associated_glycoprotein	79,109	myelin-associated_glycoprotein	9,39	myelin-associated glycoprotein	myelin-associated glycoprotein	4099	4099	Gene	Gene	formation|nmod|START_ENTITY formation|amod|END_ENTITY	Degraded myelin-associated_glycoprotein -LRB- dMAG -RRB- formation from pure human brain myelin-associated_glycoprotein -LRB- MAG -RRB- is not mediated by calpain or cathepsin_L-like activities .
12558973	0	myelin-associated_glycoprotein	9,39	myelin-associated_glycoprotein	79,109	myelin-associated glycoprotein	myelin-associated glycoprotein	4099	4099	Gene	Gene	formation|amod|START_ENTITY formation|nmod|END_ENTITY	Degraded myelin-associated_glycoprotein -LRB- dMAG -RRB- formation from pure human brain myelin-associated_glycoprotein -LRB- MAG -RRB- is not mediated by calpain or cathepsin_L-like activities .
15953345	0	myelin-associated_glycoprotein	19,49	p75NTR	102,108	myelin-associated glycoprotein	p75NTR	17136(Tax:10090)	18053(Tax:10090)	Gene	Gene	Binding|nmod|START_ENTITY induces|nsubj|Binding induces|dobj|association association|nmod|END_ENTITY	Binding of soluble myelin-associated_glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction .
25151382	0	myelin-associated_glycoprotein	8,38	siglec-4a	40,49	myelin-associated glycoprotein	siglec-4a	17136(Tax:10090)	17136(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of myelin-associated_glycoprotein -LRB- siglec-4a -RRB- in the nervous system .
26002630	0	myelin-basic-protein	80,100	Adrenomedullin	0,14	myelin-basic-protein	Adrenomedullin	24547(Tax:10116)	25026(Tax:10116)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro .
26002630	0	myelin-basic-protein	80,100	Adrenomedullin	0,14	myelin-basic-protein	Adrenomedullin	24547(Tax:10116)	25026(Tax:10116)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro .
23196718	0	myelin_and_lymphocyte_protein	16,45	MAL	47,50	myelin and lymphocyte protein	MAL	25263(Tax:10116)	25263(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of myelin_and_lymphocyte_protein -LRB- MAL -RRB- after traumatic spinal_cord_injury in rats .
23224601	0	myelin_and_lymphocyte_protein	14,43	MAL	45,48	myelin and lymphocyte protein	MAL	4118	4118	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of myelin_and_lymphocyte_protein -LRB- MAL -RRB- in oral carcinogenesis .
8734434	0	myelin_basic_protein	89,109	70-kDa_heat_shock_cognate_protein	33,66	myelin basic protein	70-kDa heat shock cognate protein	24547(Tax:10116)	24468(Tax:10116)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Antisense oligonucleotide to the 70-kDa_heat_shock_cognate_protein inhibits synthesis of myelin_basic_protein .
1323434	0	myelin_basic_protein	30,50	Angiotensin_II	0,14	myelin basic protein	Angiotensin II	4155	183	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates two myelin_basic_protein / microtubule-associated_protein_2 kinases in cultured vascular smooth muscle cells .
7745622	0	myelin_basic_protein	46,66	Basic_fibroblast_growth_factor	0,30	myelin basic protein	Basic fibroblast growth factor	24547(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor down-regulates myelin_basic_protein gene expression and alters myelin compaction of mature oligodendrocytes in vitro .
12534941	0	myelin_basic_protein	42,62	CD4	16,19	myelin basic protein	CD4	24547(Tax:10116)	24932(Tax:10116)	Gene	Gene	specific|nmod|START_ENTITY +|xcomp|specific +|nsubj|IL-4 IL-4|amod|responsive responsive|dep|END_ENTITY	IL-4 responsive CD4 + T cells specific for myelin_basic_protein : IL-2 confers a prolonged postactivation refractory phase .
1284651	0	myelin_basic_protein	50,70	CD4	45,48	myelin basic protein	CD4	4155	920	Gene	Gene	START_ENTITY|nsubj|+ +|compound|END_ENTITY	Human CD8 + T cell clone regulates autologous CD4 + myelin_basic_protein specific T cells .
1371525	0	myelin_basic_protein	132,152	CD4	69,72	myelin basic protein	CD4	4155	920	Gene	Gene	usage|nmod|START_ENTITY usage|nmod|specific specific|compound|END_ENTITY	Diversity in fine specificity and T cell receptor usage of the human CD4 + cytotoxic T cell response specific for the immunodominant myelin_basic_protein peptide 87-106 .
17442539	0	myelin_basic_protein	36,56	CD4	85,88	myelin basic protein	CD4	17196(Tax:10090)	12504(Tax:10090)	Gene	Gene	immunization|nmod|START_ENTITY Epicutaneous|acl|immunization induces|nsubj|Epicutaneous induces|ccomp|double double|nsubj|+ +|compound|END_ENTITY	Epicutaneous -LRB- EC -RRB- immunization with myelin_basic_protein -LRB- MBP -RRB- induces TCRalphabeta + CD4 + CD8 + double positive suppressor cells that protect from experimental_autoimmune_encephalomyelitis -LRB- EAE -RRB- .
26526848	0	myelin_basic_protein	51,71	CD4	20,23	myelin basic protein	CD4	4155	920	Gene	Gene	lymphocytes|nmod|START_ENTITY lymphocytes|nsubj|activation activation|nmod|+ +|compound|END_ENTITY	Early activation of CD4 + and CD8 + T lymphocytes by myelin_basic_protein in subjects with MS. BACKGROUND : Multiple_sclerosis is the most common autoimmune_disorder affecting the central nervous system .
7532684	0	myelin_basic_protein	55,75	CD4	132,135	myelin basic protein	CD4	4155	920	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	The T cell response of HLA-DR transgenic_mice to human myelin_basic_protein and other antigens in the presence and absence of human CD4 .
7533179	0	myelin_basic_protein	15,35	CD4	115,118	myelin basic protein	CD4	24547(Tax:10116)	24932(Tax:10116)	Gene	Gene	agonist|nsubj|START_ENTITY agonist|acl:relcl|converted converted|nmod|blockade blockade|nmod|END_ENTITY	Autologous rat myelin_basic_protein is a partial agonist that is converted into a full antagonist upon blockade of CD4 .
7541826	0	myelin_basic_protein	31,51	CD4	79,82	myelin basic protein	CD4	17196(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|mediate mediate|nsubj|+ +|nummod|END_ENTITY	Induction of oral tolerance to myelin_basic_protein in CD8-depleted mice : both CD4 + and CD8 + cells mediate active suppression .
7679649	0	myelin_basic_protein	34,54	CD4	56,59	myelin basic protein	CD4	4155	920	Gene	Gene	autoimmunity|nmod|START_ENTITY autoimmunity|dep|cells cells|nummod|END_ENTITY	Human T cell autoimmunity against myelin_basic_protein : CD4 + cells recognizing epitopes of the T_cell_receptor beta chain from a myelin_basic_protein-specific T cell clone .
9510211	0	myelin_basic_protein	58,78	CD8	96,99	myelin basic protein	CD8	4155	925	Gene	Gene	lymphocytes|amod|START_ENTITY lymphocytes|compound|END_ENTITY	MHC class I-restricted lysis of human oligodendrocytes by myelin_basic_protein peptide-specific CD8 T lymphocytes .
15100291	0	myelin_basic_protein	86,106	Cathepsin_G	0,11	myelin basic protein	Cathepsin G	4155	1511	Gene	Gene	processing|nmod|START_ENTITY controls|dobj|processing controls|nsubj|END_ENTITY	Cathepsin_G , and not the asparagine-specific endoprotease , controls the processing of myelin_basic_protein in lysosomes from human B lymphocytes .
7657701	0	myelin_basic_protein	73,93	DNA-binding_protein	8,27	myelin basic protein	DNA-binding protein	17196(Tax:10090)	26386(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene stimulates|dobj|transcription stimulates|nsubj|END_ENTITY	A 39-kD DNA-binding_protein from mouse brain stimulates transcription of myelin_basic_protein gene in oligodendrocytic cells .
7682655	0	myelin_basic_protein	76,96	DNA-binding_protein	28,47	myelin basic protein	DNA-binding protein	17196(Tax:10090)	26386(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	A developmentally regulated DNA-binding_protein from mouse brain stimulates myelin_basic_protein gene expression .
2475642	0	myelin_basic_protein	51,71	Epidermal_growth_factor	0,23	myelin basic protein	Epidermal growth factor	17196(Tax:10090)	13645(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Epidermal_growth_factor inhibits the expression of myelin_basic_protein in oligodendrocytes .
9952416	0	myelin_basic_protein	15,35	Fyn	58,61	myelin basic protein	Fyn	17196(Tax:10090)	14360(Tax:10090)	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Stimulation of myelin_basic_protein gene transcription by Fyn tyrosine kinase for myelination .
18039685	0	myelin_basic_protein	174,194	GSK-3beta	118,127	myelin basic protein	GSK-3beta	4155	2932	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Biochemical characterization of phospholipids , sulfatide and heparin as potent stimulators for autophosphorylation of GSK-3beta and the GSK-3beta-mediated phosphorylation of myelin_basic_protein in vitro .
11122251	0	myelin_basic_protein	14,34	MBP	36,39	myelin basic protein	MBP	4155	4155	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of myelin_basic_protein -LRB- MBP -RRB- epitopes in human non-neural cells revealed by two anti-MBP IgM monoclonal antibodies .
1697235	0	myelin_basic_protein	10,30	MBP	32,35	myelin basic protein	MBP	100344447(Tax:9986)	100344447(Tax:9986)	Gene	Gene	Assay|nmod|START_ENTITY Assay|appos|END_ENTITY	-LSB- Assay of myelin_basic_protein -LRB- MBP -RRB- antibody in the cerebrospinal fluid and serum of rabbits with experimental_allergic_encephalomyelitis -LRB- EAE -RRB- before and after sensitization -RSB- .
19556180	0	myelin_basic_protein	14,34	MBP	36,39	myelin basic protein	MBP	24547(Tax:10116)	24547(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of myelin_basic_protein -LRB- MBP -RRB- on the bioelectric activity of spinal cord and cerebellar neurones .
2414074	0	myelin_basic_protein	26,46	MBP	53,56	myelin basic protein	MBP	4155	4155	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of the human myelin_basic_protein gene -LRB- MBP -RRB- to region 18q22 -- qter by in situ hybridization .
8621121	0	myelin_basic_protein	95,115	MBP	117,120	myelin basic protein	MBP	4155	4155	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	PCR typing of DNA fragments of the two short tandem repeat -LRB- STR -RRB- systems upstream of the human myelin_basic_protein -LRB- MBP -RRB- gene in Danes and Greenland Eskimos .
9345452	0	myelin_basic_protein	78,98	MBP	100,103	myelin basic protein	MBP	4155	4155	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	PCR typing of two short tandem repeat -LRB- STR -RRB- structures upstreams of the human myelin_basic_protein -LRB- MBP -RRB- gene ; the genetic susceptibility in multiple_sclerosis and monosymptomatic idiopathic optic_neuritis in Danes .
6200496	0	myelin_basic_protein	50,70	Myelin-associated_glycoprotein	0,30	myelin basic protein	Myelin-associated glycoprotein	476160(Tax:9615)	611884(Tax:9615)	Gene	Gene	produced|nmod|START_ENTITY produced|nsubjpass|END_ENTITY	Myelin-associated_glycoprotein is produced before myelin_basic_protein in cultured oligodendrocytes .
10364361	0	myelin_basic_protein	45,65	Puralpha	94,102	myelin basic protein	Puralpha	17196(Tax:10090)	19290(Tax:10090)	Gene	Gene	factor|compound|START_ENTITY factor|appos|END_ENTITY	Association of JC_virus large T antigen with myelin_basic_protein transcription factor -LRB- MEF-1 / Puralpha -RRB- in hypomyelinated brains of mice transgenically expressing T antigen .
10457364	0	myelin_basic_protein	14,34	Sp1	57,60	myelin basic protein	Sp1	4155	6667	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Regulation of myelin_basic_protein gene transcription by Sp1 and Puralpha : evidence for association of Sp1 and Puralpha in brain .
7527866	0	myelin_basic_protein	25,45	T-cell_receptor	62,77	myelin basic protein	T-cell receptor	4155	6962	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	-LSB- Immune response against myelin_basic_protein and analysis of T-cell_receptor in multiple_sclerosis -RSB- .
9808760	0	myelin_basic_protein	19,39	alpha2-macroglobulin	75,95	myelin basic protein	alpha2-macroglobulin	4155	2	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of soluble myelin_basic_protein to various conformational forms of alpha2-macroglobulin .
2421004	0	myelin_basic_protein	50,70	cathepsin_D	22,33	myelin basic protein	cathepsin D	4155	1509	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Acidic lipids enhance cathepsin_D cleavage of the myelin_basic_protein .
2458871	0	myelin_basic_protein	30,50	interleukin_1	54,67	myelin basic protein	interleukin 1	4155	3552	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Multiple_sclerosis : effect of myelin_basic_protein on interleukin_1 , interleukin_2 production and interleukin_2 receptor expression in vitro .
2458871	0	myelin_basic_protein	30,50	interleukin_2	69,82	myelin basic protein	interleukin 2	4155	3558	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Multiple_sclerosis : effect of myelin_basic_protein on interleukin_1 , interleukin_2 production and interleukin_2 receptor expression in vitro .
8609422	0	myelin_basic_protein	29,49	myelin_oligodendrocyte_glycoprotein	72,107	myelin basic protein	myelin oligodendrocyte glycoprotein	17196(Tax:10090)	17441(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Encephalitogenic epitopes of myelin_basic_protein , proteolipid_protein , myelin_oligodendrocyte_glycoprotein for experimental_allergic_encephalomyelitis induction in Biozzi ABH -LRB- H-2Ag7 -RRB- mice share an amino_acid motif .
1717701	0	myelin_basic_protein	24,44	quaking	69,76	myelin basic protein	quaking	17196(Tax:10090)	19317(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY distribution|nmod|mRNA distribution|nmod|oligodendrocytes oligodendrocytes|amod|END_ENTITY	Spatial distribution of myelin_basic_protein mRNA and polypeptide in quaking oligodendrocytes in culture .
6170761	0	myelin_basic_protein	25,45	quaking	79,86	myelin basic protein	quaking	17196(Tax:10090)	19317(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|system system|nmod|END_ENTITY	Regional distribution of myelin_basic_protein in the central nervous system of quaking , jimpy , and normal mice during development and aging .
8609422	0	myelin_oligodendrocyte_glycoprotein	72,107	ABH	172,175	myelin oligodendrocyte glycoprotein	ABH	17441(Tax:10090)	211064(Tax:10090)	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Encephalitogenic epitopes of myelin_basic_protein , proteolipid_protein , myelin_oligodendrocyte_glycoprotein for experimental_allergic_encephalomyelitis induction in Biozzi ABH -LRB- H-2Ag7 -RRB- mice share an amino_acid motif .
12616478	0	myelin_oligodendrocyte_glycoprotein	25,60	CD4	0,3	myelin oligodendrocyte glycoprotein	CD4	4340	920	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	CD4 T cell activation by myelin_oligodendrocyte_glycoprotein is suppressed by adult but not cord blood CD25 + T cells .
14561137	0	myelin_oligodendrocyte_glycoprotein	24,59	MOG	61,64	myelin oligodendrocyte glycoprotein	MOG	24558(Tax:10116)	24558(Tax:10116)	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Extracellular domain of myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- exhibits solvent-dependent conformational transitions .
15660663	0	myelin_oligodendrocyte_glycoprotein	21,56	MOG	58,61	myelin oligodendrocyte glycoprotein	MOG	4340	4340	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic study of the myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- gene in schizophrenia .
8522338	0	myelin_oligodendrocyte_glycoprotein	69,104	MOG	106,109	myelin oligodendrocyte glycoprotein	MOG	4340	4340	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphic tri - and tetranucleotide repeats in exons 1 and 8 of the myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- gene .
9192283	0	myelin_oligodendrocyte_glycoprotein	29,64	MOG	66,69	myelin oligodendrocyte glycoprotein	MOG	24558(Tax:10116)	24558(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The regional distribution of myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- in the developing rat CNS : an in vivo immunohistochemical study .
9394837	0	myelin_oligodendrocyte_glycoprotein	43,78	MOG	150,153	myelin oligodendrocyte glycoprotein	MOG	4340	4340	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Predominance of the autoimmune response to myelin_oligodendrocyte_glycoprotein -LRB- MOG -RRB- in multiple_sclerosis : reactivity to the extracellular domain of MOG is directed against three main regions .
8609422	0	myelin_oligodendrocyte_glycoprotein	72,107	myelin_basic_protein	29,49	myelin oligodendrocyte glycoprotein	myelin basic protein	17441(Tax:10090)	17196(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Encephalitogenic epitopes of myelin_basic_protein , proteolipid_protein , myelin_oligodendrocyte_glycoprotein for experimental_allergic_encephalomyelitis induction in Biozzi ABH -LRB- H-2Ag7 -RRB- mice share an amino_acid motif .
26347141	0	myelin_oligodendrocyte_glycoprotein	4,39	nerve_growth_factor	55,74	myelin oligodendrocyte glycoprotein	nerve growth factor	17441(Tax:10090)	18049(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The myelin_oligodendrocyte_glycoprotein directly binds nerve_growth_factor to modulate central axon circuitry .
10071056	0	myelin_protein_zero	41,60	MPZ	62,65	myelin protein zero	MPZ	4359	4359	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Thr124Met mutation in the peripheral myelin_protein_zero -LRB- MPZ -RRB- gene is associated with a clinically distinct Charcot-Marie-Tooth phenotype .
12845552	0	myelin_protein_zero	63,82	MPZ	84,87	myelin protein zero	MPZ	4359	4359	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Charcot-Marie-Tooth_disease : a novel Tyr145Ser mutation in the myelin_protein_zero -LRB- MPZ , P0 -RRB- gene causes different phenotypes in homozygous and heterozygous carriers within one family .
25720167	0	myelin_protein_zero	74,93	MPZ	95,98	myelin protein zero	MPZ	4359	4359	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A Costa Rican family affected with Charcot-Marie-Tooth_disease due to the myelin_protein_zero -LRB- MPZ -RRB- p.Thr124Met mutation shares the Belgian haplotype .
18341605	0	myelin_transcription_factor_1	105,134	MYT1	141,145	myelin transcription factor 1	MYT1	4661	4661	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mental_retardation in a girl with a subtelomeric deletion on chromosome 20q and complete deletion of the myelin_transcription_factor_1 gene -LRB- MYT1 -RRB- .
16172915	0	myeloid-associated_differentiation_marker	30,71	MYADM	73,78	myeloid-associated differentiation marker	MYADM	50918(Tax:10090)	50918(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the mouse myeloid-associated_differentiation_marker -LRB- MYADM -RRB- gene : promoter analysis and protein localization .
17167770	0	myeloid_Elf-1-like_factor	26,51	MEF	53,56	myeloid Elf-1-like factor	MEF	56501(Tax:10090)	56501(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The suppressive effect of myeloid_Elf-1-like_factor -LRB- MEF -RRB- in osteogenic differentiation .
20066738	0	myeloid_cell_leukemia-1	95,118	Hepatopoietin_Cn	0,16	myeloid cell leukemia-1	Hepatopoietin Cn	4170	8125	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Hepatopoietin_Cn suppresses apoptosis of human hepatocellular_carcinoma cells by up-regulating myeloid_cell_leukemia-1 .
16317687	0	myeloid_cell_leukemia-1	26,49	Interleukin_6	0,13	myeloid cell leukemia-1	Interleukin 6	4170	3569	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin_6 upregulates myeloid_cell_leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells .
20085644	0	myeloid_cell_leukemia-1	45,68	Vascular_endothelial_growth_factor	0,34	myeloid cell leukemia-1	Vascular endothelial growth factor	4170	7422	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor regulates myeloid_cell_leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate_cancer cells .
20085644	0	myeloid_cell_leukemia-1	45,68	c-MET	125,130	myeloid cell leukemia-1	c-MET	4170	4233	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|activation activation|nmod|END_ENTITY	Vascular_endothelial_growth_factor regulates myeloid_cell_leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate_cancer cells .
19582795	0	myeloid_cell_leukemia-1_protein	19,50	Mcl-1	52,57	myeloid cell leukemia-1 protein	Mcl-1	4170	4170	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic role of myeloid_cell_leukemia-1_protein -LRB- Mcl-1 -RRB- expression in human gastric_cancer .
23244564	0	myeloid_cell_leukemia_1	20,43	Mcl-1	45,50	myeloid cell leukemia 1	Mcl-1	4170	4170	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of potent myeloid_cell_leukemia_1 -LRB- Mcl-1 -RRB- inhibitors using fragment-based methods and structure-based design .
21841196	0	myeloid_cell_leukemia_sequence_1	78,110	Mcl-1	112,117	myeloid cell leukemia sequence 1	Mcl-1	4170	4170	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Activating_transcription_factor-6 -LRB- ATF6 -RRB- mediates apoptosis with reduction of myeloid_cell_leukemia_sequence_1 -LRB- Mcl-1 -RRB- protein via induction of WW_domain_binding_protein_1 .
2259228	0	myeloid_cell_nuclear_differentiation_antigen	20,64	MNDA	66,70	myeloid cell nuclear differentiation antigen	MNDA	4332	4332	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human myeloid_cell_nuclear_differentiation_antigen -LRB- MNDA -RRB- in acute_leukemias .
8749721	0	myeloid_cell_nuclear_differentiation_antigen	6,50	nucleolin	73,82	myeloid cell nuclear differentiation antigen	nucleolin	4332	4691	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human myeloid_cell_nuclear_differentiation_antigen binds specifically to nucleolin .
18209086	0	myeloid_differentiation_factor_88	4,37	CD4	62,65	myeloid differentiation factor 88	CD4	17874(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|function function|compound|END_ENTITY	The myeloid_differentiation_factor_88 -LRB- MyD88 -RRB- is required for CD4 + T cell effector function in a murine model of inflammatory_bowel_disease .
24969711	0	myeloid_differentiation_factor_88	49,82	Toll-like_receptor_4	28,48	myeloid differentiation factor 88	Toll-like receptor 4	4615	7099	Gene	Gene	pathway|amod|START_ENTITY Effects|dep|pathway Effects|nmod|END_ENTITY	-LSB- Effects of sulforaphane on Toll-like_receptor_4 / myeloid_differentiation_factor_88 pathway of monocyte-derived macrophages from patients with chronic_obstructive_pulmonary_disease -RSB- .
21530945	0	myeloid_differentiation_primary_response_protein_88	14,65	Myd88	67,72	myeloid differentiation primary response protein 88	Myd88	301059(Tax:10116)	301059(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of myeloid_differentiation_primary_response_protein_88 -LRB- Myd88 -RRB- in the cerebral cortex after experimental traumatic_brain_injury in rats .
23186691	0	myeloid_differentiation_primary_response_protein_88	32,83	Myd88	85,90	myeloid differentiation primary response protein 88	Myd88	4615	4615	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced cortical expression of myeloid_differentiation_primary_response_protein_88 -LRB- Myd88 -RRB- in patients with traumatic_brain_injury .
18398717	0	myeloid_leukemia	39,55	lipocalin_2	15,26	myeloid leukemia	lipocalin 2	14025(Tax:10090)	16819(Tax:10090)	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|nmod|END_ENTITY	Requirement of lipocalin_2 for chronic myeloid_leukemia .
2157659	0	myeloperoxidase	50,65	C1q	69,72	myeloperoxidase	C1q	4353	712	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Protective and inactivating effects of neutrophil myeloperoxidase on C1q activity .
18339606	0	myeloperoxidase	78,93	CD40	106,110	myeloperoxidase	CD40	4353	958	Gene	Gene	ligand|amod|START_ENTITY ligand|compound|END_ENTITY	Concurrent evaluation of novel cardiac biomarkers in acute_coronary_syndrome : myeloperoxidase and soluble CD40 ligand and the risk of recurrent ischaemic_events in TACTICS-TIMI 18 .
7876246	0	myeloperoxidase	71,86	Calreticulin	0,12	myeloperoxidase	Calreticulin	4353	811	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase .
23306200	0	myeloperoxidase	44,59	Ceruloplasmin	0,13	myeloperoxidase	Ceruloplasmin	4353	12870(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Ceruloplasmin is an endogenous inhibitor of myeloperoxidase .
20736176	0	myeloperoxidase	27,42	Cot/tpl2	0,8	myeloperoxidase	Cot/tpl2	17523(Tax:10090)	26410(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Cot/tpl2 -LRB- MAP3K8 -RRB- mediates myeloperoxidase activity and hypernociception following peripheral inflammation .
7920015	0	myeloperoxidase	46,61	Eosinophil_peroxidase	0,21	myeloperoxidase	Eosinophil peroxidase	4353	8288	Gene	Gene	differs|nmod|START_ENTITY differs|nsubj|END_ENTITY	Eosinophil_peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase .
23105194	0	myeloperoxidase	15,30	GM-CSF	135,141	myeloperoxidase	GM-CSF	4353	1437	Gene	Gene	activity|amod|START_ENTITY Enhancement|nmod|activity treated|nsubj|Enhancement treated|nmod|Granulocyte_Macrophage_Colony_Stimulating_Factor Granulocyte_Macrophage_Colony_Stimulating_Factor|appos|END_ENTITY	Enhancement of myeloperoxidase activity in WBCS in oral_cancer patients treated with Granulocyte_Macrophage_Colony_Stimulating_Factor -LRB- GM-CSF -RRB- - A pilot study .
8246607	0	myeloperoxidase	25,40	GM-CSF	15,21	myeloperoxidase	GM-CSF	4353	1437	Gene	Gene	release|amod|START_ENTITY effects|nmod|release effects|nmod|END_ENTITY	The effects of GM-CSF on myeloperoxidase release in normal and myelodysplastic neutrophils .
12167444	0	myeloperoxidase	21,36	MPO	38,41	myeloperoxidase	MPO	100725291	100725291	Gene	Gene	Immunoreactivity|nmod|START_ENTITY Immunoreactivity|appos|END_ENTITY	Immunoreactivity for myeloperoxidase -LRB- MPO -RRB- in the vestibule after the injection of bacterial lipopolysaccharide into the middle ear .
15865234	0	myeloperoxidase	71,86	MPO	88,91	myeloperoxidase	MPO	4353	4353	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Cytofluorimetric assay for evaluation of CD16 receptor expression and myeloperoxidase -LRB- MPO -RRB- activity of neutrophils in patients with psoriasis_vulgaris treated with PUVA -RSB- .
1653580	0	myeloperoxidase	27,42	MPO	44,47	myeloperoxidase	MPO	4353	4353	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Cytofluorometric study of myeloperoxidase -LRB- MPO -RRB- expression in neutrophilic granulocytes of subjects with primary or secondary MPO_deficiency : analysis of the histographic antigen distribution using the Kolmogorov-Smirnov mathematical model -RSB- .
17613595	0	myeloperoxidase	69,84	MPO	86,89	myeloperoxidase	MPO	4353	4353	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An association study of two functional promotor polymorphisms in the myeloperoxidase -LRB- MPO -RRB- gene in multiple_sclerosis .
22427832	0	myeloperoxidase	66,81	MPO	83,86	myeloperoxidase	MPO	4353	4353	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Menopausal status modifies breast_cancer risk associated with the myeloperoxidase -LRB- MPO -RRB- G463A polymorphism in Caucasian women : a meta-analysis .
24222831	0	myeloperoxidase	12,27	MPO	29,32	myeloperoxidase	MPO	4353	4353	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of myeloperoxidase -LRB- MPO -RRB- for prognostic evaluation in sensitive cardiac_troponin_I negative chest_pain patients in the emergency_department .
2550177	0	myeloperoxidase	24,39	MPO	46,49	myeloperoxidase	MPO	4353	4353	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the human myeloperoxidase gene -LRB- MPO -RRB- to bands q21 .3 -- q23 of chromosome 17 .
26232301	0	myeloperoxidase	51,66	MPO	68,71	myeloperoxidase	MPO	4353	4353	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Smart imaging of acute_lung_injury : exploration of myeloperoxidase -LRB- MPO -RRB- activity using in vivo endoscopic confocal fluorescence microscopy -LRB- ECFM -RRB- .
26232301	0	myeloperoxidase	51,66	MPO	68,71	myeloperoxidase	MPO	4353	4353	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Smart imaging of acute_lung_injury : exploration of myeloperoxidase -LRB- MPO -RRB- activity using in vivo endoscopic confocal fluorescence microscopy -LRB- ECFM -RRB- .
8182931	0	myeloperoxidase	58,73	MPO	75,78	myeloperoxidase	MPO	17523(Tax:10090)	17523(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A myeloid-lineage-specific enhancer upstream of the mouse myeloperoxidase -LRB- MPO -RRB- gene .
8683986	0	myeloperoxidase	49,64	MPO	66,69	myeloperoxidase	MPO	4353	4353	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cis-elements in the promoter region of the human myeloperoxidase -LRB- MPO -RRB- gene .
9783807	0	myeloperoxidase	76,91	MPO	93,96	myeloperoxidase	MPO	4353	4353	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of an upstream enhancer containing an AML1 site in the human myeloperoxidase -LRB- MPO -RRB- gene .
8383257	0	myeloperoxidase	60,75	SKM-1	117,122	myeloperoxidase	SKM-1	4353	6329	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic_leukemia cell line , SKM-1 .
10699463	0	myeloperoxidase	34,49	TNFalpha	8,16	myeloperoxidase	TNFalpha	4353	7124	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of TNFalpha in regulation of myeloperoxidase expression in irradiated HL60 promyelocytic cells .
21190299	0	myeloperoxidase	34,49	Toll-like_receptor_2	0,20	myeloperoxidase	Toll-like receptor 2	17523(Tax:10090)	24088(Tax:10090)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Toll-like_receptor_2 induces Th17 myeloperoxidase autoimmunity while Toll-like_receptor_9 drives Th1 autoimmunity in murine vasculitis .
18778866	0	myeloperoxidase	61,76	adiponectin	22,33	myeloperoxidase	adiponectin	4353	9370	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	High molecular weight adiponectin correlates positively with myeloperoxidase in patients with type_2_diabetes_mellitus .
15792522	0	myeloperoxidase	31,46	antithrombin_III	11,27	myeloperoxidase	antithrombin III	303413(Tax:10116)	304917(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effects of antithrombin_III on myeloperoxidase activity , superoxide dismutase activity , and malondialdehyde levels and histopathological findings after spinal_cord_injury in the rat .
2444596	0	myeloperoxidase	36,51	granulocyte_colony-stimulating_factor	88,125	myeloperoxidase	granulocyte colony-stimulating factor	4353	1440	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte_colony-stimulating_factor .
21605158	0	myeloperoxidase	81,96	heat_shock_protein	45,63	myeloperoxidase	heat shock protein	4353	7190	Gene	Gene	patients|nmod|START_ENTITY END_ENTITY|nmod|patients	Increased concentrations of antibody against heat_shock_protein in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody positive microscopic_polyangiitis .
10334872	0	myeloperoxidase	11,26	mast_cell_tryptase	66,84	myeloperoxidase	mast cell tryptase	4353	25823	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|END_ENTITY	Neutrophil myeloperoxidase is a potent and selective inhibitor of mast_cell_tryptase .
8386428	0	myeloperoxidase	20,35	myeloperoxidase	59,74	myeloperoxidase	myeloperoxidase	4353	4353	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between myeloperoxidase and antibodies against myeloperoxidase measured by chemiluminescence .
8386428	0	myeloperoxidase	59,74	myeloperoxidase	20,35	myeloperoxidase	myeloperoxidase	4353	4353	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between myeloperoxidase and antibodies against myeloperoxidase measured by chemiluminescence .
8655890	0	myeloperoxidase	34,49	platelet_activating_factor	82,108	myeloperoxidase	platelet activating factor	4353	9768	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Nasal neutrophilia and release of myeloperoxidase induced by nasal challenge with platelet_activating_factor : different degrees of responsiveness in atopic and nonatopic subjects .
8076204	0	myf-5	45,50	MyoD	76,80	myf-5	MyoD	17877(Tax:10090)	17927(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Expression of myogenic factors in the mouse : myf-5 , the first member of the MyoD gene family to be transcribed during skeletal myogenesis .
11317223	0	myo-inositol_monophosphatase_2	32,62	IMPA2	64,69	myo-inositol monophosphatase 2	IMPA2	3613	3613	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence for association of the myo-inositol_monophosphatase_2 -LRB- IMPA2 -RRB- gene with schizophrenia in Japanese samples .
7664340	0	myoD	14,18	MSX1	0,4	myoD	MSX1	4654	4487	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids .
7787058	0	myoF	30,34	myosin	56,62	myoF	myosin	26509	79784	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	Molecular genetic analysis of myoF , a new Dictyostelium myosin I gene .
20643096	0	myocardial_lipid_droplet_protein	27,59	PPARgamma	83,92	myocardial lipid droplet protein	PPARgamma	66968(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	The gene expression of the myocardial_lipid_droplet_protein is highly regulated by PPARgamma in adipocytes differentiated from MEFs or SVCs .
20446923	0	myocardin	60,69	Angiotensin_II	0,14	myocardin	Angiotensin II	246297(Tax:10116)	24179(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY mediate|dobj|induction mediate|nsubj|END_ENTITY	Angiotensin_II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes .
24567363	0	myocardin	27,36	Arp5	0,4	myocardin	Arp5	93649	79913	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Arp5 is a key regulator of myocardin in smooth muscle cells .
25190111	0	myocardin	96,105	MicroRNA-135b	0,13	myocardin	MicroRNA-135b	93649	442891	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	MicroRNA-135b promotes proliferation , invasion and migration of osteosarcoma cells by degrading myocardin .
20484220	0	myocardin	111,120	PDGFRbeta	25,34	myocardin	PDGFRbeta	214384(Tax:10090)	18596(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Contribution of CXCR4 -LRB- + -RRB- / PDGFRbeta -LRB- + -RRB- progenitor cells in hypoxic_alveolar_arterioles muscularization : role of myocardin .
21984848	0	myocardin	154,163	serum_response_factor	132,153	myocardin	serum response factor	93649	6722	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Transforming_growth_factor-b1-induced_transcript_1 protein , a novel marker for smooth muscle contractile phenotype , is regulated by serum_response_factor / myocardin protein .
25384061	0	myocardin	19,28	tumor_necrosis_factor-a	43,66	myocardin	tumor necrosis factor-a	93649	7124	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Dual regulation of myocardin expression by tumor_necrosis_factor-a in vascular smooth muscle cells .
10617907	0	myocilin	4,12	MYOC	14,18	myocilin	MYOC	4653	4653	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The myocilin -LRB- MYOC -RRB- gene expression in the human trabecular meshwork .
11133859	0	myocilin	18,26	MYOC	28,32	myocilin	MYOC	4653	4653	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of the myocilin -LRB- MYOC -RRB- glaucoma gene in monkey and human steroid-induced ocular_hypertension .
17893664	0	myocilin	35,43	MYOC	45,49	myocilin	MYOC	4653	4653	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of mutations in the myocilin -LRB- MYOC -RRB- gene in Taiwanese patients with juvenile-onset_open-angle_glaucoma .
9446806	0	myocilin	34,42	MYOC	49,53	myocilin	MYOC	4653	4653	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization of the human myocilin gene -LRB- MYOC -RRB- responsible for primary open angle_glaucoma -LRB- GLC1A -RRB- .
25197353	0	myocilin	44,52	transforming_growth_factor-b2	11,40	myocilin	transforming growth factor-b2	4653	7042	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of transforming_growth_factor-b2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells .
17630987	0	myocyte-enhancer_factor_2C	97,123	Brain-derived_neurotrophic_factor	0,33	myocyte-enhancer factor 2C	Brain-derived neurotrophic factor	4208	627	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor stimulates the transcriptional and neuroprotective activity of myocyte-enhancer_factor_2C through an ERK1/2-RSK 2 signaling cascade .
8449897	0	myocyte-specific_enhancer-binding_factor	8,48	MEF-2	50,55	myocyte-specific enhancer-binding factor	MEF-2	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of myocyte-specific_enhancer-binding_factor -LRB- MEF-2 -RRB- in transcriptional regulation of the alpha-cardiac myosin heavy chain gene .
12700764	0	myocyte_enhancer_factor-2	72,97	Cabin1	62,68	myocyte enhancer factor-2	Cabin1	4205	23523	Gene	Gene	recruitment|nmod|START_ENTITY recruitment|nmod|END_ENTITY	Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte_enhancer_factor-2 .
8817457	0	myocyte_enhancer_factor-2	50,75	MEF2	77,81	myocyte enhancer factor-2	MEF2	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Early expression of the different isoforms of the myocyte_enhancer_factor-2 -LRB- MEF2 -RRB- protein in myogenic as well as non-myogenic cell lineages during mouse embryogenesis .
20923879	0	myocyte_enhancer_factor-2	14,39	Mef2	41,45	myocyte enhancer factor-2	Mef2	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Heterogeneous myocyte_enhancer_factor-2 -LRB- Mef2 -RRB- activation in myocytes predicts focal scarring in hypertrophic_cardiomyopathy .
23137781	0	myocyte_enhancer_factor_2	77,102	MEF2	104,108	myocyte enhancer factor 2	MEF2	17260(Tax:10090)	17260(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Cross-talk between glycogen_synthase_kinase_3b -LRB- GSK3b -RRB- and p38MAPK regulates myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- activity in skeletal and cardiac muscle .
9753748	0	myocyte_enhancer_factor_2	15,40	MEF2	42,46	myocyte enhancer factor 2	MEF2	4205	4205	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of myocyte_enhancer_factor_2 -LRB- MEF2 -RRB- with a mitogen-activated protein kinase , ERK5/BMK1 .
19106103	0	myocyte_enhancer_factor_2	120,145	phosphoinositide_3-kinase	66,91	myocyte enhancer factor 2	phosphoinositide 3-kinase	4205	5293	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide_3-kinase / AKT-dependent activation of myocyte_enhancer_factor_2 .
15132737	0	myocyte_enhancer_factor_2A	20,46	ERK5	0,4	myocyte enhancer factor 2A	ERK5	4205	5598	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	ERK5 is targeted to myocyte_enhancer_factor_2A -LRB- MEF2A -RRB- through a MAPK docking motif .
20585884	0	myocyte_enhancer_factor_2C	49,75	MEF2C	77,82	myocyte enhancer factor 2C	MEF2C	512254(Tax:9913)	512254(Tax:9913)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Nucleotide sequence and variations of the bovine myocyte_enhancer_factor_2C -LRB- MEF2C -RRB- gene promoter in Bos_taurus cattle .
25108515	0	myocyte_enhancer_factor_2C	70,96	Mef2C	98,103	myocyte enhancer factor 2C	Mef2C	512254(Tax:9913)	512254(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Postnatal expression patterns and polymorphism analysis of the bovine myocyte_enhancer_factor_2C -LRB- Mef2C -RRB- gene .
22714905	0	myocyte_enhancer_factor_2D	43,69	MEF2D	71,76	myocyte enhancer factor 2D	MEF2D	100336730	100336730	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of new polymorphisms in the bovine myocyte_enhancer_factor_2D -LRB- MEF2D -RRB- gene on the expression rates of the longissimus dorsi muscle .
25779444	0	myocyte_enhancer_factor_2D	21,47	interleukin-10	58,72	myocyte enhancer factor 2D	interleukin-10	17261(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Transcription factor myocyte_enhancer_factor_2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death .
25890150	0	myocyte_enhancer_factor_2D	21,47	interleukin-10	58,72	myocyte enhancer factor 2D	interleukin-10	17261(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Transcription factor myocyte_enhancer_factor_2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death .
25890150	0	myocyte_enhancer_factor_2D	21,47	interleukin-10	58,72	myocyte enhancer factor 2D	interleukin-10	17261(Tax:10090)	16153(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	Transcription factor myocyte_enhancer_factor_2D regulates interleukin-10 production in microglia to protect neuronal cells from inflammation-induced death .
18502764	0	myoferlin	52,61	EHD2	32,36	myoferlin	EHD2	26509	30846	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The endocytic recycling protein EHD2 interacts with myoferlin to regulate myoblast fusion .
21968728	0	myogenic_determination_1	78,102	MyoD1	104,109	myogenic determination 1	MyoD1	281938(Tax:9913)	281938(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of an association between a single nucleotide polymorphism in the bovine myogenic_determination_1 -LRB- MyoD1 -RRB- gene and meat quality traits in indigenous Chinese cattle breeds .
12051727	0	myogenin	27,35	Androgen_receptor	0,17	myogenin	Androgen receptor	17928(Tax:10090)	11835(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Androgen_receptor enhances myogenin expression and accelerates differentiation .
23717433	0	myogenin	44,52	Kindlin_2	0,9	myogenin	Kindlin 2	17928(Tax:10090)	218952(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Kindlin_2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation .
7797078	0	myogenin	72,80	MRF4	39,43	myogenin	MRF4	17928(Tax:10090)	17878(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY results|nmod|up-regulation results|nsubj|Inactivation Inactivation|nmod|END_ENTITY	Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib_anomalies .
9186058	0	myogenin	24,32	MRF4	0,4	myogenin	MRF4	17928(Tax:10090)	17878(Tax:10090)	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	MRF4 can substitute for myogenin during early stages of myogenesis .
10694423	0	myogenin	60,68	Myf5	11,15	myogenin	Myf5	17928(Tax:10090)	17877(Tax:10090)	Gene	Gene	support|nmod|START_ENTITY Failure|acl|support Failure|nmod|END_ENTITY	Failure of Myf5 to support myogenic differentiation without myogenin , MyoD , and MRF4 .
19267618	0	myogenin	18,26	MyoD	39,43	myogenin	MyoD	17928(Tax:10090)	17927(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|not not|nmod|END_ENTITY	The expression of myogenin , but not of MyoD , is temperature-sensitive in mouse skeletal muscle cells .
20977548	0	myogenin	39,47	RNA-binding_motif_protein_24	0,28	myogenin	RNA-binding motif protein 24	17928(Tax:10090)	666794(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNA-binding_motif_protein_24 regulates myogenin expression and promotes myogenic differentiation .
12042315	0	myogenin	14,22	Raf	47,50	myogenin	Raf	17928(Tax:10090)	387609(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Inhibition of myogenin expression by activated Raf is not responsible for the block to avian myogenesis .
21701496	0	myogenin	51,59	TEAD4	21,26	myogenin	TEAD4	17928(Tax:10090)	21679(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor TEAD4 regulates expression of myogenin and the unfolded protein response genes during C2C12 cell differentiation .
9371722	0	myogenin	20,28	c-Ski	127,132	myogenin	c-Ski	17928(Tax:10090)	20481(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|c-ski c-ski|dep|C-terminus C-terminus|nmod|protein protein|amod|END_ENTITY	Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation : the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubes .
9371722	0	myogenin	20,28	c-ski	59,64	myogenin	c-ski	17928(Tax:10090)	20481(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Trans-regulation of myogenin promoter/enhancer activity by c-ski during skeletal-muscle differentiation : the C-terminus of the c-Ski protein is essential for transcriptional regulatory activity in myotubes .
23926128	0	myogenin	38,46	histone_deacetylase_5	77,98	myogenin	histone deacetylase 5	17928(Tax:10090)	15184(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	AMP-activated protein kinase mediates myogenin expression and myogenesis via histone_deacetylase_5 .
10328964	0	myogenin	141,149	insulin-like_growth_factor-I	90,118	myogenin	insulin-like growth factor-I	17928(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Tumor_necrosis_factor-alpha and basic_fibroblast_growth_factor differentially inhibit the insulin-like_growth_factor-I induced expression of myogenin in C2C12 myoblasts .
8058986	0	myoglobin	11,20	Myo	22,25	myoglobin	Myo	4151	4151	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	-LSB- Levels of myoglobin -LRB- Myo -RRB- in blood of patients during an early phase after kidney transplantation -RSB- .
3756181	0	myoglobin	33,42	haptoglobin	6,17	myoglobin	haptoglobin	4151	3240	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human haptoglobin binds to human myoglobin .
10984101	0	myomesin	55,63	myosin	30,36	myomesin	myosin	395524(Tax:9031)	395534(Tax:9031)	Gene	Gene	proteins|dep|START_ENTITY proteins|amod|END_ENTITY	Developmental relationship of myosin binding proteins -LRB- myomesin , connectin and C-protein -RRB- to myosin in chicken somites as studied by immunofluorescence microscopy .
18480125	0	myomesin2	76,85	SIM2	43,47	myomesin2	SIM2	9172	6493	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel , non-canonical E-box sequence .
24187137	0	myonectin	24,33	mammalian_target_of_rapamycin	48,77	myonectin	mammalian target of rapamycin	151176	2475	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Skeletal muscle-derived myonectin activates the mammalian_target_of_rapamycin -LRB- mTOR -RRB- pathway to suppress autophagy in liver .
8214011	0	myopathies	57,67	dystrophin	16,26	dystrophin	dystrophin	1756	1756	Gene	Gene	Localization|nmod|START_ENTITY Localization|nmod|END_ENTITY	Localization of dystrophin and beta-spectrin in vacuolar myopathies .
10090768	0	myosin	20,26	ATPase	103,109	myosin	ATPase	79784	1769	Gene	Gene	loop|amod|START_ENTITY sequence|nmod|loop affects|nsubj|sequence affects|nmod|cycle cycle|compound|END_ENTITY	The sequence of the myosin 50-20K loop affects Myosin 's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity .
11231583	0	myosin	2,8	ATPase	31,37	myosin	ATPase	79784	1769	Gene	Gene	mutation|amod|START_ENTITY uncouples|nsubj|mutation uncouples|dobj|activity activity|amod|END_ENTITY	A myosin II mutation uncouples ATPase activity from motility and shortens step size .
11278776	0	myosin	4,10	ATPase	87,93	myosin	ATPase	79784	1769	Gene	Gene	helix|amod|START_ENTITY remains|nsubj|helix remains|xcomp|intact intact|nmod|cycle cycle|compound|END_ENTITY	The myosin relay helix to converter interface remains intact throughout the actomyosin ATPase cycle .
11853967	0	myosin	39,45	ATPase	46,52	myosin	ATPase	79784	1769	Gene	Gene	response|nmod|START_ENTITY END_ENTITY|nsubj|response	Differential response of fast and slow myosin ATPase from skeletal muscle to F-actin and to phalloidin_F-actin .
124603	0	myosin	41,47	ATPase	48,54	myosin	ATPase	79784	1769	Gene	Gene	reaction|amod|START_ENTITY reaction|compound|END_ENTITY	-LSB- Study of the stationary kinetics of the myosin ATPase reaction in the presence of calcium -RSB- .
12547786	0	myosin	92,98	ATPase	23,29	myosin	ATPase	79784	1769	Gene	Gene	cycle|nmod|START_ENTITY activation|nmod|cycle activation|compound|END_ENTITY	Chemical decoupling of ATPase activation and force production from the contractile cycle in myosin by steric hindrance of lever-arm_movement .
127356	0	myosin	8,14	ATPase	29,35	myosin	ATPase	79784	1769	Gene	Gene	START_ENTITY|dep|preparation preparation|appos|END_ENTITY	Cardiac myosin : preparation , ATPase in chronic heart_hypertrophy .
129988	0	myosin	78,84	ATPase	34,40	myosin	ATPase	79784	1769	Gene	Gene	groups|amod|START_ENTITY substitution|nmod|groups modification|nmod|substitution sensitivity|dep|modification sensitivity|nmod|END_ENTITY	Calcium sensitivity of actomyosin ATPase : its modification by substitution of myosin sulfhydryl groups .
149560	0	myosin	111,117	ATPase	92,98	myosin	ATPase	79784	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The effect of mechanical stretching of the myosin rod component -LRB- fragment LMMMM S-2 -RRB- on the ATPase activity of myosin .
149560	0	myosin	43,49	ATPase	92,98	myosin	ATPase	79784	1769	Gene	Gene	component|compound|START_ENTITY stretching|nmod|component effect|nmod|stretching effect|nmod|activity activity|amod|END_ENTITY	The effect of mechanical stretching of the myosin rod component -LRB- fragment LMMMM S-2 -RRB- on the ATPase activity of myosin .
14965039	0	myosin	24,30	ATPase	17,23	myosin	ATPase	79784	1769	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	-LSB- Effect of pH on ATPase myosin activity of different muscle types -RSB- .
20362584	0	myosin	53,59	ATPase	69,75	myosin	ATPase	38001(Tax:7227)	36731(Tax:7227)	Gene	Gene	interface|nmod|START_ENTITY Mutating|dobj|interface Mutating|nsubj|activity activity|amod|END_ENTITY	Mutating the converter-relay interface of Drosophila myosin perturbs ATPase activity , actin motility , myofibril stability and flight ability .
2527847	0	myosin	46,52	ATPase	15,21	myosin	ATPase	79784	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Measurement of ATPase activity of immobilized myosin heads .
27061920	0	myosin	24,30	ATPase	4,10	myosin	ATPase	79784	1769	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|amod|END_ENTITY	The ATPase mechanism of myosin and actomyosin .
2940240	0	myosin	37,43	ATPase	57,63	myosin	ATPase	79784	1769	Gene	Gene	peptide|nmod|START_ENTITY Involvement|nmod|peptide heads|nsubj|Involvement heads|nmod|activity activity|amod|END_ENTITY	Involvement of the 50-kDa peptide of myosin heads in the ATPase activity revealed by fluorescent modification with 4-fluoro-7-nitrobenz-2-oxa-1 ,3 - diazole .
2972697	0	myosin	74,80	ATPase	40,46	myosin	ATPase	79784	1769	Gene	Gene	START_ENTITY|nsubj|steps steps|nmod|reaction reaction|compound|END_ENTITY	Elementary steps of the actin-activated ATPase reaction of cardiac muscle myosin subfragment-1 .
3155516	0	myosin	34,40	ATPase	48,54	myosin	ATPase	79784	1769	Gene	Gene	thiols|nmod|START_ENTITY Modification|nmod|thiols alters|nsubj|Modification alters|dobj|activity activity|amod|END_ENTITY	Modification of thiols of gizzard myosin alters ATPase activity , stability of myosin filaments , and the 6-10 S conformational transition .
3155681	0	myosin	39,45	ATPase	64,70	myosin	ATPase	79784	1769	Gene	Gene	structure|nmod|START_ENTITY Effect|nmod|structure Effect|nmod|activity activity|compound|END_ENTITY	Effect of the filamentous structure of myosin on the actomyosin ATPase activity .
3160344	0	myosin	31,37	ATPase	38,44	myosin	ATPase	79784	1769	Gene	Gene	Activation|nmod|START_ENTITY END_ENTITY|nsubj|Activation	Activation of pancreatic islet myosin ATPase by ATP and actin .
4227924	0	myosin	19,25	ATPase	0,6	myosin	ATPase	79784	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	ATPase activity of myosin correlated with speed of muscle shortening .
6118361	0	myosin	29,35	ATPase	68,74	myosin	ATPase	79784	1769	Gene	Gene	chain|amod|START_ENTITY region|nmod|chain critical|nsubj|region critical|nmod|activity activity|compound|END_ENTITY	N-terminal region of gizzard myosin heavy chain is critical for the ATPase activity .
6184341	0	myosin	39,45	ATPase	46,52	myosin	ATPase	79784	1769	Gene	Gene	stains|amod|START_ENTITY stains|compound|END_ENTITY	Discrimination and consistency of five myosin ATPase stains in human normal_and_Duchenne_dystrophic_muscle .
6212085	0	myosin	54,60	ATPase	35,41	myosin	ATPase	79784	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	-LSB- Acridine orange inhibition of the ATPase activity of myosin and its fragments -RSB- .
6217171	0	myosin	31,37	ATPase	38,44	myosin	ATPase	79784	1769	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Relationship among fibre type , myosin ATPase activity and contractile properties .
6220012	0	myosin	35,41	ATPase	15,21	myosin	ATPase	79784	1769	Gene	Gene	minifilaments|compound|START_ENTITY END_ENTITY|nmod|minifilaments	The actomyosin ATPase of synthetic myosin minifilaments , filaments , and heavy meromyosin .
6240225	0	myosin	84,90	ATPase	37,43	myosin	ATPase	79784	1769	Gene	Gene	subfragment-1|compound|START_ENTITY activity|nmod|subfragment-1 activity|compound|END_ENTITY	Effect of mild heat treatment on the ATPase activity and proteolytic sensitivity of myosin subfragment-1 .
6447698	0	myosin	68,74	ATPase	75,81	myosin	ATPase	79784	1769	Gene	Gene	reaction|amod|START_ENTITY reaction|compound|END_ENTITY	The stereochemical course of phosphoric residue transfer during the myosin ATPase reaction .
8132717	0	myosin	58,64	ATPase	12,18	myosin	ATPase	79784	1769	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain .
8368268	0	myosin	35,41	ATPase	42,48	myosin	ATPase	79784	481	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Polylysine activates smooth muscle myosin ATPase activity via induction of a 10S to 6S transition .
8436225	0	myosin	14,20	ATPase	21,27	myosin	ATPase	79784	1769	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Inhibition of myosin ATPase activity by human myasthenia_gravis antibodies reactive with the acetylcholine receptor .
8994611	0	myosin	19,25	ATPase	0,6	myosin	ATPase	79784	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	ATPase activity of myosin in hair bundles of the bullfrog 's sacculus .
9458041	0	myosin	80,86	ATPase	39,45	myosin	ATPase	79784	1769	Gene	Gene	molecule|compound|START_ENTITY observation|nmod|molecule observation|nmod|END_ENTITY	Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin .
9889810	0	myosin	36,42	ATPase	15,21	myosin	ATPase	79784	1769	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|activities activities|compound|END_ENTITY	Measurement of ATPase activities of myosin at the level of tracks and single molecules .
10373480	0	myosin	59,65	M3_muscarinic_acetylcholine_receptors	0,37	myosin	M3 muscarinic acetylcholine receptors	79784	1131	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	M3_muscarinic_acetylcholine_receptors regulate cytoplasmic myosin by a process involving RhoA and requiring conventional protein_kinase_C isoforms .
16642020	0	myosin	23,29	MYH3	43,47	myosin	MYH3	79784	4621	Gene	Gene	chain|amod|START_ENTITY chain|appos|END_ENTITY	Mutations in embryonic myosin heavy chain -LRB- MYH3 -RRB- cause Freeman-Sheldon_syndrome and Sheldon-Hall_syndrome .
15699387	0	myosin	39,45	MYH7	47,51	myosin	MYH7	79784	4625	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Myosin storage myopathy : slow skeletal myosin -LRB- MYH7 -RRB- mutation in two isolated cases .
12732190	0	myosin	51,57	Myosin_light_chain_kinase	0,25	myosin	Myosin light chain kinase	79784	4638	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Myosin_light_chain_kinase stimulates smooth muscle myosin ATPase activity by binding to the myosin heads without phosphorylating the myosin_light_chain .
4221495	0	myosin	84,90	adenosinetriphosphatase	48,71	myosin	adenosinetriphosphatase	79784	481	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Age changes in content of sulfhydryl groups and adenosinetriphosphatase activity of myosin .
6225457	0	myosin	68,74	adenosinetriphosphatase	13,36	myosin	adenosinetriphosphatase	79784	481	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Mechanism of adenosinetriphosphatase activity of trinitrophenylated myosin subfragment 1 .
6457630	0	myosin	104,110	adenosinetriphosphatase	72,95	myosin	adenosinetriphosphatase	79784	481	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Excitation energy transfer studies on the proximity between SH1 and the adenosinetriphosphatase site in myosin subfragment 1 .
12903776	0	myosin	81,87	filamin	33,40	myosin	filamin	79784	2318	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The bi-directional regulation of filamin on the ATPase activity of smooth muscle myosin .
21447067	0	myosin	104,110	human_germinal_center_associated_lymphoma	33,74	myosin	human germinal center associated lymphoma	79784	257144	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Germinal center-specific protein human_germinal_center_associated_lymphoma directly interacts with both myosin and actin and increases the binding of myosin to actin .
7787058	0	myosin	56,62	myoF	30,34	myosin	myoF	79784	26509	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Molecular genetic analysis of myoF , a new Dictyostelium myosin I gene .
10984101	0	myosin	30,36	myomesin	55,63	myosin	myomesin	395534(Tax:9031)	395524(Tax:9031)	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Developmental relationship of myosin binding proteins -LRB- myomesin , connectin and C-protein -RRB- to myosin in chicken somites as studied by immunofluorescence microscopy .
7929586	0	myosin	70,76	myosin-VI	8,17	myosin	myosin-VI	79784	4646	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|dep|characterization	Porcine myosin-VI : characterization of a new mammalian unconventional myosin .
17192269	0	myosin	26,32	myosin-binding_protein_C	63,87	myosin	myosin-binding protein C	79784	4607	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Dissecting the N-terminal myosin binding site of human cardiac myosin-binding_protein_C .
3676447	0	myosin	49,55	myosin_light_chain_kinase	20,45	myosin	myosin light chain kinase	79784	4638	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|nmod|phosphorylation	Effects of purified myosin_light_chain_kinase on myosin light chain phosphorylation and catecholamine secretion in digitonin-permeabilized chromaffin cells .
3713741	0	myosin	26,32	myotonic_dystrophy	36,54	myosin	myotonic dystrophy	79784	1760	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Promiscuous expression of myosin in myotonic_dystrophy .
16403913	0	myosin	101,107	nucleolin	27,36	myosin	nucleolin	79784	4691	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|function function|nmod|END_ENTITY	The angiogenic function of nucleolin is mediated by vascular_endothelial_growth_factor and nonmuscle myosin .
16087679	0	myosin	78,84	surfactant_protein_A	22,42	myosin	surfactant protein A	79784	653509	Gene	Gene	18A|amod|START_ENTITY 210|nmod|18A 210|nsubj|Identification Identification|nmod|receptor receptor|compound|END_ENTITY	Identification of the surfactant_protein_A receptor 210 as the unconventional myosin 18A .
7946398	0	myosin	50,56	surfactant_protein_A	15,35	myosin	surfactant protein A	79784	653509	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of surfactant_protein_A with cellular myosin .
22326025	0	myosin-II	15,24	Par-1	0,5	myosin-II	Par-1	31554(Tax:7227)	2768852(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY controls|dobj|activity controls|nsubj|END_ENTITY	Par-1 controls myosin-II activity through myosin_phosphatase to regulate border cell migration .
20850431	0	myosin-IIB	43,53	CLN3	23,27	myosin-IIB	CLN3	77579(Tax:10090)	12752(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3 -LRB- - / - -RRB- cells .
20850431	0	myosin-IIB	43,53	Cln3	86,90	myosin-IIB	Cln3	77579(Tax:10090)	12752(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|motility motility|nmod|cells cells|amod|END_ENTITY	A novel interaction of CLN3 with nonmuscle myosin-IIB and defects in cell motility of Cln3 -LRB- - / - -RRB- cells .
7929586	0	myosin-VI	8,17	myosin	70,76	myosin-VI	myosin	4646	79784	Gene	Gene	START_ENTITY|dep|characterization characterization|nmod|END_ENTITY	Porcine myosin-VI : characterization of a new mammalian unconventional myosin .
17192269	0	myosin-binding_protein_C	63,87	myosin	26,32	myosin-binding protein C	myosin	4607	79784	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Dissecting the N-terminal myosin binding site of human cardiac myosin-binding_protein_C .
25014165	0	myosin_18A	88,98	MYO18A	100,106	myosin 18A	MYO18A	399687	399687	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of the extreme carboxyl-terminus of PAK-interacting exchange factor b -LRB- bPIX -RRB- to myosin_18A -LRB- MYO18A -RRB- is required for epithelial cell migration .
24466350	0	myosin_IXB	23,33	RhoGAP	4,10	myosin IXB	RhoGAP	4650	392	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The RhoGAP activity of myosin_IXB is critical for osteoclast podosome patterning , motility , and resorptive capacity .
17314409	0	myosin_IXb	42,52	RhoGAP	53,59	myosin IXb	RhoGAP	4650	392	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	The Myosin_IXb motor activity targets the myosin_IXb RhoGAP domain as cargo to sites of actin polymerization .
10969013	0	myosin_V	18,26	ATPase	27,33	myosin V	ATPase	4644	1769	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	ADP inhibition of myosin_V ATPase activity .
11906161	0	myosin_VI	37,46	DOC-2	0,5	myosin VI	DOC-2	4646	1601	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	DOC-2 / DAB2 is the binding partner of myosin_VI .
15837803	0	myosin_VI	17,26	Optineurin	0,10	myosin VI	Optineurin	4646	10133	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	Optineurin links myosin_VI to the Golgi complex and is involved in Golgi organization and exocytosis .
19417007	0	myosin_VI	25,34	Otoferlin	0,9	myosin VI	Otoferlin	17920(Tax:10090)	83762(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Otoferlin interacts with myosin_VI : implications for maintenance of the basolateral synaptic structure of the inner hair cell .
12050163	0	myosin_VI	57,66	SAP97	15,20	myosin VI	SAP97	315840(Tax:10116)	25252(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of SAP97 with minus-end-directed actin motor myosin_VI .
19423668	0	myosin_VIIA	70,81	ATPase	51,57	myosin VIIA	ATPase	4647	1769	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	The tail binds to the head-neck domain , inhibiting ATPase activity of myosin_VIIA .
24790701	0	myosin_Va	83,92	Erk	97,100	myosin Va	Erk	4644	5594	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin_Va via Erk signaling .
15760894	0	myosin_Va	80,89	melanophilin	36,48	myosin Va	melanophilin	4644	79083	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Activation of myosin_Va function by melanophilin , a specific docking partner of myosin_Va .
17513864	0	myosin_Va	28,37	melanophilin	98,110	myosin Va	melanophilin	4644	79083	Gene	Gene	site|compound|START_ENTITY site|nmod|domain domain|nmod|END_ENTITY	Identification of a minimal myosin_Va binding site within an intrinsically unstructured domain of melanophilin .
8355600	0	myosin_alkali_light-chain	69,94	Mlc1	96,100	myosin alkali light-chain	Mlc1	43323(Tax:7227)	43323(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Conservation of alternative splicing and genomic organization of the myosin_alkali_light-chain -LRB- Mlc1 -RRB- gene among Drosophila species .
11171584	0	myosin_heavy_chain	20,38	IIB	16,19	myosin heavy chain	IIB	111671(Tax:10090)	50771(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Mutation of the IIB myosin_heavy_chain gene results in muscle fiber loss and compensatory_hypertrophy .
21470888	0	myosin_heavy_chain	18,36	MHC	38,41	myosin heavy chain	MHC	3133	3133	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The expression of myosin_heavy_chain -LRB- MHC -RRB- genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes .
10707845	0	myosin_heavy_chain	14,32	MyHC	34,38	myosin heavy chain	MyHC	29605(Tax:10116)	29605(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of myosin_heavy_chain -LRB- MyHC -RRB- isoforms in rat intrafusal muscle fibres after neonatal deefferentation and subsequent denervation .
22976277	0	myosin_heavy_chain_11	73,94	MYH11	96,101	myosin heavy chain 11	MYH11	24582(Tax:10116)	24582(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Estrogen-induced maldevelopment of the penis involves down-regulation of myosin_heavy_chain_11 -LRB- MYH11 -RRB- expression , a biomarker for smooth muscle cell differentiation .
7835087	0	myosin_heavy_chain_12	45,66	MYH12	68,73	myosin heavy chain 12	MYH12	4644	4644	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and regional assignment of the human myosin_heavy_chain_12 -LRB- MYH12 -RRB- gene to chromosome band 15q21 .
26152646	0	myosin_heavy_chain_9	96,116	MYH9	90,94	myosin heavy chain 9	MYH9	4627	4627	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Estimated glomerular filtration rate -LRB- eGFR -RRB- , 25 -LRB- OH -RRB- _ D3 , chronic_kidney_disease -LRB- CKD -RRB- , the MYH9 -LRB- myosin_heavy_chain_9 -RRB- gene in old and very elderly people .
16556853	0	myosin_light_chain	18,36	Apelin	0,6	myosin light chain	Apelin	170790(Tax:10090)	30878(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Apelin stimulates myosin_light_chain phosphorylation in vascular smooth muscle cells .
24100445	0	myosin_light_chain	34,52	MLC	54,57	myosin light chain	MLC	23209	23209	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	cAMP signaling regulates platelet myosin_light_chain -LRB- MLC -RRB- phosphorylation and shape change through targeting the RhoA-Rho kinase-MLC phosphatase signaling pathway .
26074085	0	myosin_light_chain-2	13,33	MYL2	35,39	myosin light chain-2	MYL2	4633	4633	Gene	Gene	Functions|nmod|START_ENTITY Functions|appos|END_ENTITY	Functions of myosin_light_chain-2 -LRB- MYL2 -RRB- in cardiac muscle and disease .
10036190	0	myosin_light_chain_kinase	74,99	MYLK	101,105	myosin light chain kinase	MYLK	4638	4638	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A genomic region encompassing a cluster of olfactory receptor genes and a myosin_light_chain_kinase -LRB- MYLK -RRB- gene is duplicated on human chromosome regions 3q13-q21 and 3p13 .
11306802	0	myosin_light_chain_kinase	15,40	MYLK	42,46	myosin light chain kinase	MYLK	4638	4638	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The functional myosin_light_chain_kinase -LRB- MYLK -RRB- gene localizes with marker D3S3552 on human chromosome 3q21 in a > 5-Mb yeast artificial chromosome region and is not linked to olfactory receptor genes .
10748018	0	myosin_light_chain_kinase	19,44	PAK2	69,73	myosin light chain kinase	PAK2	4638	5062	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of myosin_light_chain_kinase by p21-activated kinase PAK2 .
18511912	0	myosin_light_chain_kinase	14,39	angiotensin_II	54,68	myosin light chain kinase	angiotensin II	288057(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of myosin_light_chain_kinase expression by angiotensin_II in hypertension .
12408982	0	myosin_light_chain_kinase	53,78	cortactin	21,30	myosin light chain kinase	cortactin	4638	2017	Gene	Gene	START_ENTITY|nsubj|interaction interaction|nmod|END_ENTITY	Novel interaction of cortactin with endothelial cell myosin_light_chain_kinase .
3676447	0	myosin_light_chain_kinase	20,45	myosin	49,55	myosin light chain kinase	myosin	4638	79784	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Effects of purified myosin_light_chain_kinase on myosin light chain phosphorylation and catecholamine secretion in digitonin-permeabilized chromaffin cells .
22326025	0	myosin_phosphatase	42,60	Par-1	0,5	myosin phosphatase	Par-1	49070(Tax:7227)	2768852(Tax:7227)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	Par-1 controls myosin-II activity through myosin_phosphatase to regulate border cell migration .
23345589	0	myosin_phosphatase_targeting_subunit_1	79,117	caspase-3	37,46	myosin phosphatase targeting subunit 1	caspase-3	4659	836	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Myosin phosphatase is inactivated by caspase-3 cleavage and phosphorylation of myosin_phosphatase_targeting_subunit_1 during apoptosis .
22425609	0	myosin_regulatory_light_chain	89,118	MLC2	120,124	myosin regulatory light chain	MLC2	4633	4633	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Gene duplication and conversion events shaped three homologous , differentially expressed myosin_regulatory_light_chain -LRB- MLC2 -RRB- genes .
14671324	0	myostatin	21,30	BMP-1	38,43	myostatin	BMP-1	17700(Tax:10090)	12153(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of latent myostatin by the BMP-1 / tolloid family of metalloproteinases .
19108573	0	myostatin	21,30	Caveolin-3	0,10	myostatin	Caveolin-3	2660	859	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Caveolin-3 regulates myostatin signaling .
16380093	0	myostatin	14,23	Decorin	0,7	myostatin	Decorin	2660	1634	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Decorin binds myostatin and modulates its activity to muscle cells .
22205678	0	myostatin	22,31	GDF-8	33,38	myostatin	GDF-8	17700(Tax:10090)	17700(Tax:10090)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of myostatin -LRB- GDF-8 -RRB- following musculoskeletal_injury and the effects of exogenous myostatin on muscle and bone healing .
10610713	0	myostatin	41,50	GDF8	52,56	myostatin	GDF8	2660	2660	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Frequent sequence variation in the human myostatin -LRB- GDF8 -RRB- gene as a marker for analysis of muscle-related phenotypes .
18462481	0	myostatin	43,52	GDF8	54,58	myostatin	GDF8	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two single nucleotide polymorphisms in the myostatin -LRB- GDF8 -RRB- gene have significant association with muscle_depth of commercial Charollais sheep .
12212941	0	myostatin	44,53	MSTN	60,64	myostatin	MSTN	399534(Tax:9823)	399534(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of three SNPs in the porcine myostatin gene -LRB- MSTN -RRB- .
19392824	0	myostatin	50,59	MSTN	66,70	myostatin	MSTN	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A frameshift mutation in the coding region of the myostatin gene -LRB- MSTN -RRB- affects carcass conformation and fatness in Norwegian White Sheep -LRB- Ovis_aries -RRB- .
19505313	0	myostatin	41,50	MSTN	52,56	myostatin	MSTN	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An insertion in the coding region of the myostatin -LRB- MSTN -RRB- gene affects carcass conformation and fatness in the Norwegian Spaelsau -LRB- Ovis_aries -RRB- .
19799595	0	myostatin	27,36	MSTN	43,47	myostatin	MSTN	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the ovine myostatin gene -LRB- MSTN -RRB- and their association with growth and carcass traits in New Zealand Romney sheep .
20932346	0	myostatin	94,103	MSTN	105,109	myostatin	MSTN	100033832(Tax:9796)	100033832(Tax:9796)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A genome-wide SNP-association study confirms a sequence variant -LRB- g. 66493737C > T -RRB- in the equine myostatin -LRB- MSTN -RRB- gene as the most powerful predictor of optimum racing distance for Thoroughbred racehorses .
23613242	0	myostatin	21,30	MSTN	37,41	myostatin	MSTN	100860887	100860887	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the myostatin gene -LRB- MSTN -RRB- and its relationship with growth traits in goat breeds .
24299184	0	myostatin	88,97	MSTN	99,103	myostatin	MSTN	100860887	100860887	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of 5 ' upstream region and investigation of TTTTA deletion in 5 ' UTR of myostatin -LRB- MSTN -RRB- gene in Indian goat breeds .
24796976	0	myostatin	75,84	MSTN	86,90	myostatin	MSTN	100125998(Tax:9986)	100125998(Tax:9986)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new single nucleotide polymorphism in the rabbit -LRB- Oryctolagus_cuniculus -RRB- myostatin -LRB- MSTN -RRB- gene is associated with carcass composition traits .
25273961	0	myostatin	98,107	MSTN	109,113	myostatin	MSTN	100033832(Tax:9796)	100033832(Tax:9796)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the 227 bp short interspersed nuclear element -LRB- SINE -RRB- insertion of the promoter of the myostatin -LRB- MSTN -RRB- gene in different horse breeds .
26081604	0	myostatin	65,74	MSTN	81,85	myostatin	MSTN	443449(Tax:9940)	443449(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Two single nucleotide polymorphisms in the promoter of the ovine myostatin gene -LRB- MSTN -RRB- and their effect on growth and carcass muscle traits in New Zealand Romney sheep .
19903317	0	myostatin	87,96	Myostatin	0,9	myostatin	Myostatin	2660	2660	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Myostatin expression during human muscle hypertrophy and subsequent atrophy : increased myostatin with detraining .
25646693	0	myostatin	47,56	PPARy	0,5	myostatin	PPARy	2660	5468	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	PPARy and MyoD are differentially regulated by myostatin in adipose-derived stem cells and muscle satellite cells .
16077203	0	myostatin	45,54	Transforming_growth_factor-beta1	0,32	myostatin	Transforming growth factor-beta1	17700(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 upregulates myostatin expression in mouse C2C12 myoblasts .
17689926	0	myostatin	14,23	c-Jun_N-terminal_kinase	37,60	myostatin	c-Jun N-terminal kinase	17700(Tax:10090)	26419(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of myostatin signaling by c-Jun_N-terminal_kinase in C2C12 cells .
22987245	0	myostatin	83,92	ghrelin	10,17	myostatin	ghrelin	29152(Tax:10116)	59301(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of ghrelin and its analogues , BIM-28131 and BIM-28125 , on the expression of myostatin in a rat heart_failure model .
11038172	1	myotilin	119,127	gamma-filamin	52,65	myotilin	gamma-filamin	9499	2318	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	gamma-filamin , the muscle-specific filamin isoform , interacts with myotilin .
8499920	0	myotonic_dystrophy	38,56	DM_kinase	58,67	myotonic dystrophy	DM kinase	1760	13400(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and genomic sequence of the myotonic_dystrophy -LRB- DM_kinase -RRB- gene .
19567095	0	myotonic_dystrophy	58,76	MyoD	1,5	myotonic dystrophy	MyoD	1760	4654	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- MyoD mRNA expression in skeletal muscle of patients with myotonic_dystrophy -RSB- .
3713741	0	myotonic_dystrophy	36,54	myosin	26,32	myotonic dystrophy	myosin	1760	79784	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Promiscuous expression of myosin in myotonic_dystrophy .
15099703	0	myotonic_dystrophy_1	52,72	CUG_binding_protein_1	22,43	myotonic dystrophy 1	CUG binding protein 1	1760	10658	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Altered expression of CUG_binding_protein_1 mRNA in myotonic_dystrophy_1 : possible RNA-RNA interaction .
17987120	0	myotonic_dystrophy_protein_kinase	8,41	DMPK	43,47	myotonic dystrophy protein kinase	DMPK	13400(Tax:10090)	13400(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of myotonic_dystrophy_protein_kinase -LRB- DMPK -RRB- in glucose homeostasis and muscle insulin action .
8288237	0	myotonic_dystrophy_protein_kinase	11,44	DMPK	46,50	myotonic dystrophy protein kinase	DMPK	1760	1760	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Absence of myotonic_dystrophy_protein_kinase -LRB- DMPK -RRB- mRNA as a result of a triplet repeat expansion in myotonic_dystrophy .
9490724	0	myotonic_dystrophy_protein_kinase	85,118	MKBP	0,4	myotonic dystrophy protein kinase	MKBP	1760	3316	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MKBP , a novel member of the small heat_shock protein family , binds and activates the myotonic_dystrophy_protein_kinase .
11335693	0	myotubularin-related_protein_2	34,64	MTMR2	66,71	myotubularin-related protein 2	MTMR2	8898	8898	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the 5 ' region of the myotubularin-related_protein_2 -LRB- MTMR2 -RRB- gene in autosomal_recessive_hereditary_neuropathy with focally folded myelin .
23188820	0	myotubularin-related_protein_6	35,65	Rab1B	103,108	myotubularin-related protein 6	Rab1B	305935(Tax:10116)	100126191(Tax:10116)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Phosphatidylinositol 3-phosphatase myotubularin-related_protein_6 -LRB- MTMR6 -RRB- is regulated by small GTPase Rab1B in the early secretory and autophagic pathways .
14507707	0	myristoylated_alanine-rich_C-kinase_substrate	16,61	MARCKS	63,69	myristoylated alanine-rich C-kinase substrate	MARCKS	4082	4082	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Location of the myristoylated_alanine-rich_C-kinase_substrate -LRB- MARCKS -RRB- effector domain in negatively charged phospholipid bicelles .
8216211	0	myristoylated_alanine-rich_C-kinase_substrate	49,94	MARCKS	41,47	myristoylated alanine-rich C-kinase substrate	MARCKS	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|compound|END_ENTITY	Effects of insulin and phorbol_esters on MARCKS -LRB- myristoylated_alanine-rich_C-kinase_substrate -RRB- phosphorylation -LRB- and other parameters of protein kinase C activation -RRB- in rat adipocytes , rat soleus muscle and BC3H-1 myocytes .
8978751	0	myristoylated_alanine-rich_C-kinase_substrate	62,107	protein_kinase_C-alpha	14,36	myristoylated alanine-rich C-kinase substrate	protein kinase C-alpha	4082	5578	Gene	Gene	correlate|amod|START_ENTITY END_ENTITY|nmod|correlate	Activation of protein_kinase_C-alpha and translocation of the myristoylated_alanine-rich_C-kinase_substrate correlate with phorbol_ester-enhanced noradrenaline release from SH-SY5Y human neuroblastoma cells .
1860846	0	myristoylated_alanine-rich_C_kinase_substrate	10,55	MACS	71,75	myristoylated alanine-rich C kinase substrate	MACS	4082	4082	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- gene -LRB- MACS -RRB- .
10859236	0	myristoylated_alanine-rich_C_kinase_substrate	19,64	MARCKS	66,72	myristoylated alanine-rich C kinase substrate	MARCKS	613548(Tax:9913)	613548(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein is associated with bovine luteal oxytocin exocytosis .
10871043	0	myristoylated_alanine-rich_C_kinase_substrate	29,74	MARCKS	76,82	myristoylated alanine-rich C kinase substrate	MARCKS	4082	4082	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulation of the binding of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- related protein to lipid bilayer membranes by calmodulin .
12067241	0	myristoylated_alanine-rich_C_kinase_substrate	33,78	MARCKS	80,86	myristoylated alanine-rich C kinase substrate	MARCKS	4082	4082	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of rho-kinase-induced myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- phosphorylation in human neuronal cells by H-1152 , a novel and specific Rho-kinase inhibitor .
12675922	0	myristoylated_alanine-rich_C_kinase_substrate	42,87	MARCKS	89,95	myristoylated alanine-rich C kinase substrate	MARCKS	17118(Tax:10090)	17118(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression and regulation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- in the hippocampus of C57/BL6J and DBA/2J mice .
12849934	0	myristoylated_alanine-rich_C_kinase_substrate	42,87	MARCKS	89,95	myristoylated alanine-rich C kinase substrate	MARCKS	4082	4082	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression and phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- in postmortem brain of suicide victims with or without depression .
12930725	0	myristoylated_alanine-rich_C_kinase_substrate	31,76	MARCKS	78,84	myristoylated alanine-rich C kinase substrate	MARCKS	613548(Tax:9913)	613548(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Spatiotemporal interactions of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein with the actin cytoskeleton and exocytosis of oxytocin upon prostaglandin_F2alpha stimulation of bovine luteal cells .
1332970	0	myristoylated_alanine-rich_C_kinase_substrate	28,73	MARCKS	75,81	myristoylated alanine-rich C kinase substrate	MARCKS	4082	4082	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Membrane association of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein appears to involve myristate-dependent binding in the absence of a myristoyl protein receptor .
1527003	0	myristoylated_alanine-rich_C_kinase_substrate	35,80	MARCKS	82,88	myristoylated alanine-rich C kinase substrate	MARCKS	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Glucose-induced phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- in isolated rat pancreatic islets .
1860846	0	myristoylated_alanine-rich_C_kinase_substrate	10,55	MARCKS	57,63	myristoylated alanine-rich C kinase substrate	MARCKS	4082	4082	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	The human myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- gene -LRB- MACS -RRB- .
20205598	0	myristoylated_alanine-rich_C_kinase_substrate	14,59	MARCKS	61,67	myristoylated alanine-rich C kinase substrate	MARCKS	4082	4082	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Inhibition of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein inhibits ozone-induced airway neutrophilia and inflammation .
7616238	0	myristoylated_alanine-rich_C_kinase_substrate	19,64	MARCKS	66,72	myristoylated alanine-rich C kinase substrate	MARCKS	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- by proline-directed protein kinases and its dephosphorylation .
7768946	0	myristoylated_alanine-rich_C_kinase_substrate	28,73	MARCKS	75,81	myristoylated alanine-rich C kinase substrate	MARCKS	396473(Tax:9031)	396473(Tax:9031)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Membrane association of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein .
7859929	0	myristoylated_alanine-rich_C_kinase_substrate	72,117	MARCKS	119,125	myristoylated alanine-rich C kinase substrate	MARCKS	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Arginine vasopressin -LRB- AVP -RRB- causes the reversible phosphorylation of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein in the ovine anterior pituitary : evidence that MARCKS phosphorylation is associated with adrenocorticotropin -LRB- ACTH -RRB- secretion .
9397959	0	myristoylated_alanine-rich_C_kinase_substrate	72,117	MARCKS	119,125	myristoylated alanine-rich C kinase substrate	MARCKS	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Arginine vasopressin -LRB- AVP -RRB- causes the reversible phosphorylation of the myristoylated_alanine-rich_C_kinase_substrate -LRB- MARCKS -RRB- protein in the ovine anterior pituitary : evidence that MARCKS phosphorylation is associated with adrenocorticotropin -LRB- ACTH -RRB- secretion .
1335598	0	myristoylated_alanine_rich_C_kinase_substrate	71,116	MARCKS	118,124	myristoylated alanine rich C kinase substrate	MARCKS	81520(Tax:10116)	81520(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Transforming growth factor-beta -LRB- TGF-b -RRB- induced phosphorylation of the myristoylated_alanine_rich_C_kinase_substrate -LRB- MARCKS -RRB- protein in ovarian granulosa cells is modulated by follicle stimulating hormone -LRB- FSH -RRB- .
8380671	0	myxoma_growth_factor	102,122	Transforming_growth_factor_alpha	0,32	myxoma growth factor	Transforming growth factor alpha	932144(Tax:10273)	100009150(Tax:9986)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	Transforming_growth_factor_alpha , Shope fibroma growth factor , and vaccinia growth factor can replace myxoma_growth_factor in the induction of myxomatosis in rabbits .
24607864	0	nAChR	106,111	nicotinic_acetylcholine_receptor	72,104	nAChR	nicotinic acetylcholine receptor	1137	1137	Gene	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Cigarette smoking during pregnancy regulates the expression of specific nicotinic_acetylcholine_receptor -LRB- nAChR -RRB- subunits in the human placenta .
22198001	0	nNOS	23,27	CB2	40,43	nNOS	CB2	4842	1269	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|receptor receptor|compound|END_ENTITY	Distinct regulation of nNOS and iNOS by CB2 receptor in remote delayed neurodegeneration .
15105416	0	nNOS	79,83	NIDD	0,4	nNOS	NIDD	24598(Tax:10116)	363783(Tax:10116)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	NIDD , a novel DHHC-containing protein , targets neuronal_nitric-oxide_synthase -LRB- nNOS -RRB- to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity .
19578649	0	nNOS	36,40	angiotensin_II	11,25	nNOS	angiotensin II	24598(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|modulates modulates|compound|END_ENTITY	Endogenous angiotensin_II modulates nNOS expression in renovascular_hypertension .
9822444	0	nNOS	8,12	eNOS	45,49	nNOS	eNOS	18125(Tax:10090)	18127(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of nNOS in blood pressure regulation in eNOS null mutant mice .
24117944	0	nNOS	129,133	iNOS	104,108	nNOS	iNOS	18125(Tax:10090)	18126(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The beneficial effects of melatonin against heart mitochondrial impairment during sepsis : inhibition of iNOS and preservation of nNOS .
18071027	0	nRF1	80,84	nuclear_respiratory_factor_1	50,78	nRF1	nuclear respiratory factor 1	4899	4899	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genetic variation and association analyses of the nuclear_respiratory_factor_1 -LRB- nRF1 -RRB- gene in Chinese patients with type 2 diabetes .
16260776	0	nab2	48,52	Egr-1	0,5	nab2	Egr-1	4665	1958	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop .
16260776	0	nab2	74,78	Egr-1	0,5	nab2	Egr-1	4665	1958	Gene	Gene	promoter|amod|START_ENTITY activation|nmod|promoter establishing|nsubj|activation induces|advcl|establishing induces|nsubj|END_ENTITY	Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop .
23859118	0	nampt	92,97	nicotinamide_phosphoribosyltransferase	52,90	nampt	nicotinamide phosphoribosyltransferase	59027(Tax:10090)	59027(Tax:10090)	Gene	Gene	discovery|appos|START_ENTITY discovery|nmod|END_ENTITY	Structure-based discovery of novel amide-containing nicotinamide_phosphoribosyltransferase -LRB- nampt -RRB- inhibitors .
21062744	0	nanog	72,77	Sall1	0,5	nanog	Sall1	79923	6299	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Sall1 regulates embryonic stem cell differentiation in association with nanog .
23184089	0	nanos	51,56	Smaug	74,79	nanos	Smaug	42297(Tax:7227)	39034(Tax:7227)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	microRNA-independent recruitment of Argonaute_1 to nanos mRNA through the Smaug RNA-binding protein .
24316376	0	nasal_embryonic_LHRH_factor	27,54	NELF	56,60	nasal embryonic LHRH factor	NELF	56876(Tax:10090)	56876(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of nasal_embryonic_LHRH_factor -LRB- NELF -RRB- variants in immortalized GnRH neuronal cell lines .
18807115	0	nasopharyngeal_carcinoma	65,89	BZLF1	4,9	nasopharyngeal carcinoma	BZLF1	4864	3783744(Tax:10376)	Gene	Gene	sequence|nmod|START_ENTITY sequence|nsubj|END_ENTITY	New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal_carcinoma in southern China .
11836588	0	nasopharyngeal_carcinoma	76,100	Fas_ligand	14,24	nasopharyngeal carcinoma	Fas ligand	4864	356	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of Fas_ligand in patients with evident skull base involvement of nasopharyngeal_carcinoma .
16520653	0	nasopharyngeal_carcinoma	90,114	death-associated_protein_kinase	50,81	nasopharyngeal carcinoma	death-associated protein kinase	4864	1612	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Effect of methylation-associated silencing of the death-associated_protein_kinase gene on nasopharyngeal_carcinoma .
17720627	0	nasopharyngeal_carcinoma	88,112	interleukin-8	64,77	nasopharyngeal carcinoma	interleukin-8	4864	3576	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Single nucleotide polymorphism and haplotype association of the interleukin-8 gene with nasopharyngeal_carcinoma .
8951595	0	natriuretic_peptide_clearance_receptor	44,82	NPR-C	84,89	natriuretic peptide clearance receptor	NPR-C	25339(Tax:10116)	25339(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression and glucocorticoid regulation of natriuretic_peptide_clearance_receptor -LRB- NPR-C -RRB- mRNA in rat brain and choroid plexus .
21464461	0	natriuretic_peptide_clearance_receptor	10,48	NPR3	50,54	natriuretic peptide clearance receptor	NPR3	4883	4883	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Impact of natriuretic_peptide_clearance_receptor -LRB- NPR3 -RRB- gene variants on blood pressure in type 2 diabetes .
17343213	0	natriuretic_peptide_precursor_B	25,56	NPPB	58,62	natriuretic peptide precursor B	NPPB	4879	4879	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the natriuretic_peptide_precursor_B -LRB- NPPB -RRB- gene in patients with hypertrophic_cardiomyopathy .
26215453	0	natriuretic_peptide_receptor-A	30,60	Angiotensin_II	0,14	natriuretic peptide receptor-A	Angiotensin II	24603(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Angiotensin_II down-regulates natriuretic_peptide_receptor-A expression and guanylyl cyclase activity in H9c2 -LRB- 2-1 -RRB- cardiac_myoblast cells : Role of ROS and NF-kB .
21737535	0	natriuretic_peptide_receptor-A	92,122	atrial_natriuretic_peptide	48,74	natriuretic peptide receptor-A	atrial natriuretic peptide	24603(Tax:10116)	24602(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Glucocorticoids improve renal responsiveness to atrial_natriuretic_peptide by up-regulating natriuretic_peptide_receptor-A expression in the renal inner medullary collecting duct in decompensated heart_failure .
24259409	0	natriuretic_peptide_receptor_2	71,101	NPR2	103,107	natriuretic peptide receptor 2	NPR2	4882	4882	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Overgrowth_syndrome associated with a gain-of-function mutation of the natriuretic_peptide_receptor_2 -LRB- NPR2 -RRB- gene .
15722353	0	natriuretic_peptide_receptor_2	31,61	Npr2	63,67	natriuretic peptide receptor 2	Npr2	230103(Tax:10090)	230103(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A loss-of-function mutation in natriuretic_peptide_receptor_2 -LRB- Npr2 -RRB- gene is responsible for disproportionate dwarfism in cn/cn mouse .
12702516	0	natriuretic_peptide_receptor_A	64,94	apolipoprotein_E	97,113	natriuretic peptide receptor A	apolipoprotein E	18160(Tax:10090)	11816(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic_peptide_receptor_A - / - apolipoprotein_E - / - mice .
15149737	0	natriuretic_peptide_receptor_C	48,78	NPR-C	80,85	natriuretic peptide receptor C	NPR-C	4883	4883	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclic_adenosine_monophosphate -LRB- cAMP -RRB- increases natriuretic_peptide_receptor_C -LRB- NPR-C -RRB- expression in human aortic smooth muscle cells .
8898964	0	natural_killer_cell_inhibitory_receptor	20,59	CD94	0,4	natural killer cell inhibitory receptor	CD94	100132285	3824	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	CD94 functions as a natural_killer_cell_inhibitory_receptor for different HLA class I alleles : identification of the inhibitory form of CD94 by the use of novel monoclonal antibodies .
1672545	0	natural_killer_cell_stimulatory_factor	44,82	interferon_gamma	13,29	natural killer cell stimulatory factor	interferon gamma	3593	3458	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Induction of interferon_gamma production by natural_killer_cell_stimulatory_factor : characterization of the responder cells and synergy with other inducers .
15825023	0	natural_resistance-associated_macrophage_protein_1	16,66	NRAMP1	73,79	natural resistance-associated macrophage protein 1	NRAMP1	6556	6556	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of the natural_resistance-associated_macrophage_protein_1 gene -LRB- NRAMP1 -RRB- are associated with severe forms of pulmonary_tuberculosis .
9251591	0	natural_resistance-associated_macrophage_protein_1	69,119	NRAMP1	121,127	natural resistance-associated macrophage protein 1	NRAMP1	6556	6556	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No evidence for linkage between leprosy susceptibility and the human natural_resistance-associated_macrophage_protein_1 -LRB- NRAMP1 -RRB- gene in French Polynesia .
9699275	0	natural_resistance-associated_macrophage_protein_1	15,65	NRAMP1	67,73	natural resistance-associated macrophage protein 1	NRAMP1	100737298	100737298	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the natural_resistance-associated_macrophage_protein_1 -LRB- NRAMP1 -RRB- gene to pig chromosome 15 .
22396659	0	ncRNA	124,129	Airn	113,117	ncRNA	Airn	104968399	100271873	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	A downstream CpG island controls transcript initiation and elongation and the methylation state of the imprinted Airn macro ncRNA promoter .
19179065	0	ncRNA	23,28	c-Myc	14,19	ncRNA	c-Myc	104968399	4609	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation by c-Myc of ncRNA expression .
24817013	0	ncRuPAR	0,7	protease-activated_receptor-1	63,92	ncRuPAR	protease-activated receptor-1	100302746	2149	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	ncRuPAR inhibits gastric_cancer progression by down-regulating protease-activated_receptor-1 .
24046450	0	nebulin	4,11	SH3	12,15	nebulin	SH3	17996(Tax:10090)	100125849(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse .
11037792	0	nebulin	14,21	titin	37,42	nebulin	titin	4703	7273	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of nebulin and connectin -LRB- titin -RRB- for assembly of actin filaments during myofibrillogenesis .
15669020	0	necdin	51,57	NDN	46,49	necdin	NDN	4692	4692	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Chromatin modification of the human imprinted NDN -LRB- necdin -RRB- gene detected by in vivo footprinting .
9354807	0	necdin	10,16	NDN	23,26	necdin	NDN	17984(Tax:10090)	4692	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human necdin gene , NDN , is maternally imprinted and located in the Prader-Willi_syndrome chromosomal region .
18076965	0	nectin-1	34,42	glycoprotein_D	90,104	nectin-1	glycoprotein D	58235(Tax:10090)	13349(Tax:10090)	Gene	Gene	down-regulated|nsubjpass|START_ENTITY down-regulated|nmod|END_ENTITY	The herpes_simplex_virus receptor nectin-1 is down-regulated after trans-interaction with glycoprotein_D .
11090177	0	nectin-1alpha	30,43	glycoprotein_D	104,118	nectin-1alpha	glycoprotein D	58235(Tax:10090)	2532	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Striking similarity of murine nectin-1alpha to human nectin-1alpha -LRB- HveC -RRB- in sequence and activity as a glycoprotein_D receptor for alphaherpesvirus entry .
11090177	0	nectin-1alpha	53,66	glycoprotein_D	104,118	nectin-1alpha	glycoprotein D	58235(Tax:10090)	2532	Gene	Gene	nectin-1alpha|nmod|START_ENTITY nectin-1alpha|nmod|receptor receptor|amod|END_ENTITY	Striking similarity of murine nectin-1alpha to human nectin-1alpha -LRB- HveC -RRB- in sequence and activity as a glycoprotein_D receptor for alphaherpesvirus entry .
26177744	0	nectin-3	120,128	TGFBR2	132,138	nectin-3	TGFBR2	25945	7048	Gene	Gene	START_ENTITY|nmod|target target|compound|END_ENTITY	A new method for detection of tumor driver-dependent changes of protein sialylation in a colon_cancer cell line reveals nectin-3 as TGFBR2 target .
10580057	0	nef	91,94	AP-1	79,83	nef	AP-1	156110(Tax:11676)	3725	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Lack of negative influence on the cellular transcription factors NF-kappaB and AP-1 by the nef protein of human_immunodeficiency_virus_type_1 .
11396948	0	nef	68,71	CD4	103,106	nef	CD4	156110(Tax:11676)	920	Gene	Gene	sequences|compound|START_ENTITY sequences|nmod|downregulation downregulation|nmod|END_ENTITY	Differential effects of primary human_immunodeficiency_virus_type_1 nef sequences on downregulation of CD4 and MHC class I .
12816953	0	nef	49,52	CD4	9,12	nef	CD4	156110(Tax:11676)	920	Gene	Gene	alleles|compound|START_ENTITY alleles|nummod|END_ENTITY	Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication .
1355346	0	nef	119,122	CD4	91,94	nef	CD4	156110(Tax:11676)	920	Gene	Gene	protein|compound|START_ENTITY expressing|dobj|protein altered|xcomp|expressing altered|nmod|cells cells|compound|END_ENTITY	Activation pathways and human_immunodeficiency_virus_type_1 replication are not altered in CD4 + T cells expressing the nef protein .
19424050	0	nef	45,48	CD4	79,82	nef	CD4	6285	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|cells cells|compound|END_ENTITY	HIV escape from natural killer cytotoxicity : nef inhibits NKp44L expression on CD4 + T cells .
2014052	0	nef	73,76	CD4	66,69	nef	CD4	6285	920	Gene	Gene	Serine|nmod|START_ENTITY Serine|dobj|downregulation downregulation|nmod|END_ENTITY	Serine phosphorylation-independent downregulation of cell-surface CD4 by nef .
21165790	0	nef	50,53	CD4	0,3	nef	CD4	156110(Tax:11676)	920	Gene	Gene	alleles|compound|START_ENTITY activities|nmod|alleles class|dobj|activities class|nsubj|END_ENTITY	CD4 and MHC class 1 down-modulation activities of nef alleles from brain - and lymphoid tissue-derived primary HIV-1 isolates .
7903679	0	nef	18,21	CD4	113,116	nef	CD4	156110(Tax:11676)	920	Gene	Gene	importance|nmod|START_ENTITY importance|nmod|lymphocytes lymphocytes|compound|END_ENTITY	The importance of nef in the induction of human_immunodeficiency_virus_type_1 replication from primary quiescent CD4 lymphocytes .
8516299	0	nef	23,26	CD4	0,3	nef	CD4	156110(Tax:11676)	920	Gene	Gene	alleles|compound|START_ENTITY down-regulation|nmod|alleles down-regulation|nummod|END_ENTITY	CD4 down-regulation by nef alleles isolated from human_immunodeficiency_virus_type_1-infected individuals .
9343202	0	nef	113,116	CD4	157,160	nef	CD4	156110(Tax:11676)	920	Gene	Gene	gene|compound|START_ENTITY gene|nmod|replication replication|nmod|cells cells|compound|END_ENTITY	Mutational analysis of human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- accessory genes : requirement of a site in the nef gene for HIV-1 replication in activated CD4 + T cells in vitro and in vivo .
21059238	0	nef	23,26	HLA-B	35,40	nef	HLA-B	6285	3106	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Evolution of the HIV-1 nef gene in HLA-B * 57 positive elite suppressors .
19424050	0	nef	45,48	NKp44L	58,64	nef	NKp44L	6285	55904	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	HIV escape from natural killer cytotoxicity : nef inhibits NKp44L expression on CD4 + T cells .
16214896	0	negative_elongation_factor	2,28	TFIIS	109,114	negative elongation factor	TFIIS	26012	6919	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	A negative_elongation_factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS .
17042739	0	nell-1	33,39	runx2	56,61	nell-1	runx2	4745	860	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	Craniosynostosis-associated gene nell-1 is regulated by runx2 .
12039044	0	nemo-like_kinase	36,52	NLK	31,34	nemo-like kinase	NLK	51701	51701	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Genomic structure of the human NLK -LRB- nemo-like_kinase -RRB- gene and analysis of its promoter region .
23857283	0	nemo-like_kinase	27,43	NLK	45,48	nemo-like kinase	NLK	51701	51701	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of nemo-like_kinase -LRB- NLK -RRB- expression in patients with gallbladder_cancer .
15151990	0	nemo-like_kinase	0,16	Wnt	49,52	nemo-like kinase	Wnt	38890(Tax:7227)	35975(Tax:7227)	Gene	Gene	co-activator|nsubj|START_ENTITY co-activator|nmod|END_ENTITY	nemo-like_kinase is an essential co-activator of Wnt signaling during early zebrafish development .
17953666	0	neogenin	99,107	RGMa	0,4	neogenin	RGMa	18007(Tax:10090)	244058(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY system|nmod|receptor inhibits|nmod|system inhibits|nsubj|END_ENTITY	RGMa inhibits neurite outgrowth of neuronal progenitors from murine enteric nervous system via the neogenin receptor in vitro .
20576809	0	nephrin	33,40	Anion_exchanger_1	0,17	nephrin	Anion exchanger 1	54631(Tax:10090)	20533(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Anion_exchanger_1 interacts with nephrin in podocytes .
10997929	0	nephrin	24,31	CD2AP	0,5	nephrin	CD2AP	54631(Tax:10090)	12488(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere .
15942677	0	nephrin	82,89	FSGS	74,78	nephrin	FSGS	4868	81	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Direct effect of plasma permeability factors from patients with idiopatic FSGS on nephrin and podocin expression in human podocytes .
17923684	0	nephrin	22,29	Neph1	0,5	nephrin	Neph1	4868	55243	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization .
22747997	0	nephrin	21,28	SIRPa	0,5	nephrin	SIRPa	4868	140885	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SIRPa interacts with nephrin at the podocyte slit_diaphragm .
15504938	0	nephrin	71,78	WT1	0,3	nephrin	WT1	4868	7490	Gene	Gene	gene|compound|START_ENTITY identified|nmod|gene enhancer|acl|identified activates|dobj|enhancer activates|nsubj|END_ENTITY	WT1 activates a glomerular-specific enhancer identified from the human nephrin gene .
15579507	0	nephrin	27,34	WT1	97,100	nephrin	WT1	54631(Tax:10090)	22431(Tax:10090)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	The major podocyte protein nephrin is transcriptionally activated by the Wilms ' _ tumor suppressor WT1 .
19129671	0	nephrin	71,78	tensin2	28,35	nephrin	tensin2	54631(Tax:10090)	209039(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice .
61795	0	nerve-growth_factor	12,31	NGF	33,36	nerve-growth factor	NGF	4803	4803	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of nerve-growth_factor -LRB- NGF -RRB- in the central nervous system .
12767043	0	nerve_growth_factor	89,108	Akt	37,40	nerve growth factor	Akt	310738(Tax:10116)	24185(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY phosphorylated|nmod|stimulation phosphorylated|dobj|form form|nmod|translocates translocates|compound|END_ENTITY	Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve_growth_factor stimulation and associates with the nuclear matrix protein nucleolin .
19996110	0	nerve_growth_factor	11,30	Akt	93,96	nerve growth factor	Akt	4803	207	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Endogenous nerve_growth_factor regulates collagen expression and bladder_hypertrophy through Akt and MAPK pathways during cystitis .
9406817	0	nerve_growth_factor	10,29	BCL-2	127,132	nerve growth factor	BCL-2	4803	596	Gene	Gene	protects|nsubj|START_ENTITY protects|parataxis|role role|nmod|END_ENTITY	Autocrine nerve_growth_factor protects human keratinocytes from apoptosis through its high affinity receptor -LRB- TRK -RRB- : a role for BCL-2 .
9322157	0	nerve_growth_factor	29,48	BDNF	105,109	nerve growth factor	BDNF	310738(Tax:10116)	24225(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of the neurotrophins nerve_growth_factor , neurotrophin-3 , and brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on neurite growth from adult sensory neurons in compartmented cultures .
10219080	0	nerve_growth_factor	36,55	Bcl-2	18,23	nerve growth factor	Bcl-2	4803	596	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Activation of the Bcl-2 promoter by nerve_growth_factor is mediated by the p42/p44 MAPK cascade .
17577445	0	nerve_growth_factor	12,31	Bcl-2	87,92	nerve growth factor	Bcl-2	4803	596	Gene	Gene	pretreatment|compound|START_ENTITY Effects|nmod|pretreatment Effects|nmod|END_ENTITY	-LSB- Effects of nerve_growth_factor pretreatment on apoptosis of neurons and expression of Bcl-2 , Bax protein in brain tissue following cerebral_ischemia / reperfusion injury in gerbils -RSB- .
21500593	0	nerve_growth_factor	12,31	Bcl-2	96,101	nerve growth factor	Bcl-2	310738(Tax:10116)	24224(Tax:10116)	Gene	Gene	insulin|compound|START_ENTITY Effects|nmod|insulin Effects|nmod|END_ENTITY	-LSB- Effects of nerve_growth_factor mixed insulin on angiogenesis of burn_wounds and expressions of Bcl-2 and Bax in diabetic rats -RSB- .
23376352	0	nerve_growth_factor	33,52	Bradykinin	0,10	nerve growth factor	Bradykinin	4803	3827	Gene	Gene	production|compound|START_ENTITY modulates|dobj|production modulates|nsubj|END_ENTITY	Bradykinin modulates spontaneous nerve_growth_factor production and stretch-induced ATP release in human urothelium .
9314355	0	nerve_growth_factor	45,64	CD4	6,9	nerve growth factor	CD4	4803	920	Gene	Gene	produce|dobj|START_ENTITY +|ccomp|produce +|nsubj|END_ENTITY	Human CD4 + T cell clones produce and release nerve_growth_factor and express high-affinity nerve_growth_factor receptors .
10822447	0	nerve_growth_factor	24,43	CSF	10,13	nerve growth factor	CSF	4803	1437	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Increased CSF levels of nerve_growth_factor in patients with Alzheimer 's _ disease .
8817609	0	nerve_growth_factor	27,46	Choline_acetyltransferase	0,25	nerve growth factor	Choline acetyltransferase	310738(Tax:10116)	290567(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY changed|nsubjpass|levels changed|advmod|END_ENTITY	Choline_acetyltransferase , nerve_growth_factor and cytokine levels are changed in congenitally hydrocephalic HTX rats .
9215712	0	nerve_growth_factor	14,33	FGF-2	0,5	nerve growth factor	FGF-2	310738(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	FGF-2 induces nerve_growth_factor expression in cultured rat hippocampal neurons .
10936192	0	nerve_growth_factor	149,168	GAP-43	72,78	nerve growth factor	GAP-43	310738(Tax:10116)	29423(Tax:10116)	Gene	Gene	absence|nmod|START_ENTITY cells|nmod|absence expression|nmod|cells expression|compound|END_ENTITY	Overexpression of HuD , but not of its truncated form HuD I+II , promotes GAP-43 gene expression and neurite outgrowth in PC12 cells in the absence of nerve_growth_factor .
11703425	0	nerve_growth_factor	11,30	GAP-43	48,54	nerve growth factor	GAP-43	310738(Tax:10116)	29423(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nerve_growth_factor on expression of GAP-43 in right atria after sympathectomy in diabetic rats .
2461937	0	nerve_growth_factor	45,64	GAP-43	19,25	nerve growth factor	GAP-43	310738(Tax:10116)	29423(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Dual regulation of GAP-43 gene expression by nerve_growth_factor and glucocorticoids .
10391364	0	nerve_growth_factor	49,68	HSP70	93,98	nerve growth factor	HSP70	310738(Tax:10116)	266759(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of brain-derived_neurotrophic_factor , nerve_growth_factor , and heat_shock protein HSP70 following fluid percussion brain_injury in rats .
11705672	0	nerve_growth_factor	49,68	Interleukin-1_beta	0,18	nerve growth factor	Interleukin-1 beta	310738(Tax:10116)	24494(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY mediates|dobj|secretion mediates|nsubj|END_ENTITY	Interleukin-1_beta , but not IL-1_alpha , mediates nerve_growth_factor secretion from rat astrocytes via type I IL-1 receptor .
1951711	0	nerve_growth_factor	77,96	Interleukin-1_beta	0,18	nerve growth factor	Interleukin-1 beta	310738(Tax:10116)	24494(Tax:10116)	Gene	Gene	synthesis|compound|START_ENTITY stimulate|dobj|synthesis stimulate|nsubj|END_ENTITY	Interleukin-1_beta and tumor_necrosis_factor-alpha synergistically stimulate nerve_growth_factor synthesis in rat mesangial cells .
16923128	0	nerve_growth_factor	41,60	M-Ras	24,29	nerve growth factor	M-Ras	310738(Tax:10116)	25482(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Sustained activation of M-Ras induced by nerve_growth_factor is essential for neuronal differentiation of PC12 cells .
2026175	0	nerve_growth_factor	68,87	MAP2	48,52	nerve growth factor	MAP2	310738(Tax:10116)	25595(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation of microtubule_associated_protein_2 -LRB- MAP2 -RRB- expression by nerve_growth_factor in PC12 cells .
9559664	0	nerve_growth_factor	70,89	MKP3	62,66	nerve growth factor	MKP3	310738(Tax:10116)	116663(Tax:10116)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Induction of the mitogen-activated protein kinase phosphatase MKP3 by nerve_growth_factor in differentiating PC12 .
12162901	0	nerve_growth_factor	11,30	N-methyl-D-asparate_receptor_1	34,64	nerve growth factor	N-methyl-D-asparate receptor 1	310738(Tax:10116)	24408(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nerve_growth_factor on N-methyl-D-asparate_receptor_1 after spinal_cord_injury in rats .
1217903	0	nerve_growth_factor	14,33	NGF	35,38	nerve growth factor	NGF	4803	4803	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	-LSB- Influence of nerve_growth_factor -LRB- NGF -RRB- on formation of synapses in newt embryonic neural tube -RSB- .
1376870	0	nerve_growth_factor	13,32	NGF	34,37	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction by nerve_growth_factor -LRB- NGF -RRB- of NGF_receptor-like immunoreactivity in the preoptic area and hypothalamus of neonatal rats .
14614283	0	nerve_growth_factor	24,43	NGF	45,48	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Angiogenesis effects of nerve_growth_factor -LRB- NGF -RRB- on rat corneas .
1648856	0	nerve_growth_factor	20,39	NGF	41,44	nerve growth factor	NGF	4803	4803	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Temporal pattern of nerve_growth_factor -LRB- NGF -RRB- binding in vivo and the in vitro effects of NGF on cultures of developing auditory and vestibular neurons .
16520000	0	nerve_growth_factor	31,50	NGF	52,55	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|appos|END_ENTITY	Regulation of PrPC expression : nerve_growth_factor -LRB- NGF -RRB- activates the prion gene promoter through the MEK1 pathway in PC12 cells .
16928414	0	nerve_growth_factor	22,41	NGF	43,46	nerve growth factor	NGF	4803	4803	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The potential role of nerve_growth_factor -LRB- NGF -RRB- in painful_neuromas and the mechanism of pain relief by their relocation to muscle .
17096853	0	nerve_growth_factor	11,30	NGF	32,35	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of nerve_growth_factor -LRB- NGF -RRB- on blood vessels area and expression of the angiogenic factors VEGF and TGFbeta1 in the rat ovary .
18329889	0	nerve_growth_factor	45,64	NGF	66,69	nerve growth factor	NGF	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Ganglioside_GM1 effects on the expression of nerve_growth_factor -LRB- NGF -RRB- , Trk-A receptor , proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic -LRB- NOD -RRB- mice .
18922683	0	nerve_growth_factor	25,44	NGF	46,49	nerve growth factor	NGF	4803	4803	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Quantitative analysis of nerve_growth_factor -LRB- NGF -RRB- in the atopic_dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic_dermatitis .
19834819	0	nerve_growth_factor	10,29	NGF	31,34	nerve growth factor	NGF	103350089	103350089	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of nerve_growth_factor -LRB- NGF -RRB- on the development of preimplantation rabbit embryos in vitro .
209849	0	nerve_growth_factor	48,67	NGF	69,72	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of the retrograde transport of nerve_growth_factor -LRB- NGF -RRB- using high specific activity -LSB- 125I -RSB- NGF .
2142224	0	nerve_growth_factor	21,40	NGF	42,45	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Endogenous levels of nerve_growth_factor -LRB- NGF -RRB- are altered in experimental diabetes_mellitus : a possible role for NGF in the pathogenesis of diabetic_neuropathy .
21526490	0	nerve_growth_factor	31,50	NGF	52,55	nerve growth factor	NGF	102536531	102536531	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of nerve_growth_factor -LRB- NGF -RRB- in the testis of alpaca -LRB- llama pacos -RRB- .
21541365	0	nerve_growth_factor	51,70	NGF	72,75	nerve growth factor	NGF	4803	4803	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Neurosteroid dehydroepiandrosterone interacts with nerve_growth_factor -LRB- NGF -RRB- receptors , preventing neuronal_apoptosis .
22138126	0	nerve_growth_factor	16,35	NGF	37,40	nerve growth factor	NGF	4803	4803	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Localization of nerve_growth_factor -LRB- NGF -RRB- receptors in the mitochondrial compartment : characterization and putative role .
22293692	0	nerve_growth_factor	14,33	NGF	35,38	nerve growth factor	NGF	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	-LSB- Influence of nerve_growth_factor -LRB- NGF -RRB- on distribution of perivascular nerves in tumor neovasculatures of mouse corneal -RSB- .
22526467	0	nerve_growth_factor	62,81	NGF	83,86	nerve growth factor	NGF	4803	4803	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human neural stem cells genetically modified to express human nerve_growth_factor -LRB- NGF -RRB- gene restore cognition in the mouse with ibotenic_acid-induced cognitive_dysfunction .
2318311	0	nerve_growth_factor	70,89	NGF	91,94	nerve growth factor	NGF	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phorbol_12-myristate_13-acetate -LRB- PMA -RRB- increases the expression of the nerve_growth_factor -LRB- NGF -RRB- gene in mouse L-929 fibroblasts .
23696568	0	nerve_growth_factor	121,140	NGF	142,145	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Differential effects of dehydroepiandrosterone and testosterone in prostate and colon_cancer cell apoptosis : the role of nerve_growth_factor -LRB- NGF -RRB- receptors .
24361544	0	nerve_growth_factor	6,25	NGF	27,30	nerve growth factor	NGF	4803	4803	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Serum nerve_growth_factor -LRB- NGF -RRB- levels in children with attention_deficit / hyperactivity_disorder -LRB- ADHD -RRB- .
26021968	0	nerve_growth_factor	61,80	NGF	82,85	nerve growth factor	NGF	4803	4803	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Harm avoidance involved in mediating the association between nerve_growth_factor -LRB- NGF -RRB- gene polymorphisms and antidepressant efficacy in patients with major_depressive_disorder .
26021968	0	nerve_growth_factor	61,80	NGF	82,85	nerve growth factor	NGF	4803	4803	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Harm avoidance involved in mediating the association between nerve_growth_factor -LRB- NGF -RRB- gene polymorphisms and antidepressant efficacy in patients with major_depressive_disorder .
26118751	0	nerve_growth_factor	16,35	NGF	37,40	nerve growth factor	NGF	4803	4803	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of nerve_growth_factor -LRB- NGF -RRB- in patients with major_depression_disorder and suicide risk .
3384176	0	nerve_growth_factor	17,36	NGF	38,41	nerve growth factor	NGF	396466(Tax:9031)	396466(Tax:9031)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	The synthesis of nerve_growth_factor -LRB- NGF -RRB- in developing skin is independent of innervation .
4134529	0	nerve_growth_factor	14,33	NGF	35,38	nerve growth factor	NGF	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of nerve_growth_factor -LRB- NGF -RRB- upon axoplasmic transport in sympathetic neurons of the mouse .
4211021	0	nerve_growth_factor	20,39	NGF	41,44	nerve growth factor	NGF	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Specific binding of nerve_growth_factor -LRB- NGF -RRB- by murine C 1300 neuroblastoma cells .
4937105	0	nerve_growth_factor	15,34	NGF	36,39	nerve growth factor	NGF	4803	4803	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of the nerve_growth_factor -LRB- NGF -RRB- on cell cultures of the trigeminal ganglion -RSB- .
5639608	0	nerve_growth_factor	51,70	NGF	72,75	nerve growth factor	NGF	4803	4803	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Glucose metabolism in embryonic ganglia : effect of nerve_growth_factor -LSB- NGF -RSB- and insulin .
58700	0	nerve_growth_factor	98,117	NGF	119,122	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|appos|END_ENTITY	The significance of retrograde axonal transport for the accumulation of systemically administered nerve_growth_factor -LRB- NGF -RRB- in the rat superior cervical ganglion .
6383859	0	nerve_growth_factor	14,33	NGF	35,38	nerve growth factor	NGF	4803	4803	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of nerve_growth_factor -LRB- NGF -RRB- on the catecholamine contents of two human pheochromocytomas in tissue culture .
7473570	0	nerve_growth_factor	50,69	NGF	100,103	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
7985814	0	nerve_growth_factor	25,44	NGF	46,49	nerve growth factor	NGF	4803	4803	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Developmental changes in nerve_growth_factor -LRB- NGF -RRB- binding and NGF receptor proteins trkA and p75 in the facial nerve .
8028775	0	nerve_growth_factor	20,39	NGF	41,44	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Increased levels of nerve_growth_factor -LRB- NGF -RRB- protein and mRNA and reactive gliosis following kainic_acid injection into the rat striatum .
8459651	0	nerve_growth_factor	11,30	NGF	32,35	nerve growth factor	NGF	310738(Tax:10116)	310738(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of nerve_growth_factor -LRB- NGF -RRB- in rats with basal forebrain lesions .
9211449	0	nerve_growth_factor	73,92	NGF	94,97	nerve growth factor	NGF	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- A sensitive two-site -LRB- sandwich -RRB- enzyme immunoassay system for measuring nerve_growth_factor -LRB- NGF -RRB- -RSB- .
949726	0	nerve_growth_factor	35,54	NGF	56,59	nerve growth factor	NGF	18049(Tax:10090)	18049(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of nerve_growth_factor -LRB- NGF -RRB- in the submandibular gland of adult mice by light and electron microscopy .
17306250	0	nerve_growth_factor	63,82	NK3	19,22	nerve growth factor	NK3	4803	4824	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|receptors receptors|compound|END_ENTITY	Role of tachykinin NK3 receptors in the release and effects of nerve_growth_factor in human isolated bronchi .
25945243	0	nerve_growth_factor	46,65	Nerve_growth_factor	0,19	nerve growth factor	Nerve growth factor	4803	4803	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|dep|Effect	Nerve_growth_factor in human semen : Effect of nerve_growth_factor on the normozoospermic men during cryopreservation process .
25945243	0	nerve_growth_factor	46,65	Nerve_growth_factor	0,19	nerve growth factor	Nerve growth factor	4803	4803	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|dep|Effect	Nerve_growth_factor in human semen : Effect of nerve_growth_factor on the normozoospermic men during cryopreservation process .
17663741	0	nerve_growth_factor	44,63	Plasminogen	0,11	nerve growth factor	Plasminogen	310738(Tax:10116)	85253(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Plasminogen gene expression is regulated by nerve_growth_factor .
7783948	0	nerve_growth_factor	35,54	Platelet_activating_factor	0,26	nerve growth factor	Platelet activating factor	310738(Tax:10116)	300795(Tax:10116)	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Platelet_activating_factor induces nerve_growth_factor production by rat astrocytes .
11028855	0	nerve_growth_factor	8,27	RANTES	31,37	nerve growth factor	RANTES	4803	6352	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of nerve_growth_factor in RANTES expression by keratinocytes .
2837417	0	nerve_growth_factor	51,70	SCG10	41,46	nerve growth factor	SCG10	310738(Tax:10116)	84510(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The induction of a neural-specific gene , SCG10 , by nerve_growth_factor in PC12 cells is transcriptional , protein synthesis dependent , and glucocorticoid inhibitable .
9665586	0	nerve_growth_factor	85,104	SNAP-25	0,7	nerve growth factor	SNAP-25	4803	6616	Gene	Gene	release|nmod|START_ENTITY cooperate|nmod|release cooperate|nsubj|END_ENTITY	SNAP-25 and syntaxin , but not synaptobrevin_2 , cooperate in the regulated release of nerve_growth_factor .
10330344	0	nerve_growth_factor	129,148	TRKA	73,77	nerve growth factor	TRKA	4803	4914	Gene	Gene	receptor|nmod|START_ENTITY encoding|dobj|receptor gene|acl|encoding gene|compound|END_ENTITY	Congenital_insensitivity_to_pain_with_anhidrosis : novel mutations in the TRKA -LRB- NTRK1 -RRB- gene encoding a high-affinity receptor for nerve_growth_factor .
11159935	0	nerve_growth_factor	158,177	TRKA	67,71	nerve growth factor	TRKA	4803	4914	Gene	Gene	receptor_tyrosine_kinase|nmod|START_ENTITY autophosphorylation|nmod|receptor_tyrosine_kinase missense|nmod|autophosphorylation missense|nsubj|Congenital_insensitivity Congenital_insensitivity|dep|effect effect|nmod|END_ENTITY	Congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : effect of TRKA -LRB- NTRK1 -RRB- missense mutations on autophosphorylation of the receptor_tyrosine_kinase for nerve_growth_factor .
11748840	0	nerve_growth_factor	167,186	TRKA	107,111	nerve growth factor	TRKA	4803	4914	Gene	Gene	receptor_tyrosine_kinase|nmod|START_ENTITY encoding|dobj|receptor_tyrosine_kinase mutations|acl|encoding mutations|nmod|gene gene|compound|END_ENTITY	Molecular basis of congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : mutations and polymorphisms in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve_growth_factor .
19286963	0	nerve_growth_factor	16,35	TRPV1	49,54	nerve growth factor	TRPV1	310738(Tax:10116)	83810(Tax:10116)	Gene	Gene	Contribution|nmod|START_ENTITY Contribution|acl|augmented augmented|dobj|responses responses|nummod|END_ENTITY	Contribution of nerve_growth_factor to augmented TRPV1 responses of muscle sensory neurons by femoral artery_occlusion .
17305717	0	nerve_growth_factor	64,83	Transforming_growth_factor-beta1	0,32	nerve growth factor	Transforming growth factor-beta1	4803	7040	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 up-regulates the expression of nerve_growth_factor through mitogen-activated protein kinase signaling pathways in dental pulp cells .
10614630	0	nerve_growth_factor	15,34	Trk	35,38	nerve growth factor	Trk	4803	4914	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Suppression of nerve_growth_factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate_cancer cell proliferation .
15312164	0	nerve_growth_factor	24,43	Trk	58,61	nerve growth factor	Trk	18049(Tax:10090)	4914	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|receptors receptors|compound|END_ENTITY	Autocrine regulation of nerve_growth_factor expression by Trk receptors .
7517456	0	nerve_growth_factor	30,49	Trk	71,74	nerve growth factor	Trk	18049(Tax:10090)	18211(Tax:10090)	Gene	Gene	determinants|nmod|START_ENTITY involved|nsubj|determinants involved|nmod|receptor receptor|appos|END_ENTITY	Immunological determinants of nerve_growth_factor involved in p140trk -LRB- Trk -RRB- receptor binding .
7902578	0	nerve_growth_factor	14,33	Trk	83,86	nerve growth factor	Trk	18049(Tax:10090)	18211(Tax:10090)	Gene	Gene	tyrosine|compound|START_ENTITY Expression|nmod|tyrosine kinase|nsubj|Expression kinase|dobj|END_ENTITY	Expression of nerve_growth_factor and nerve_growth_factor receptor tyrosine kinase Trk in activated CD4-positive T-cell clones .
10200344	0	nerve_growth_factor	68,87	TrkA	98,102	nerve growth factor	TrkA	4803	4914	Gene	Gene	receptor|compound|START_ENTITY polymorphisms|nmod|receptor Detection|nmod|polymorphisms Detection|appos|END_ENTITY	Detection of DNA polymorphisms and point mutations of high-affinity nerve_growth_factor receptor -LRB- TrkA -RRB- in human neuroblastoma .
10585422	0	nerve_growth_factor	44,63	TrkA	67,71	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY -|nsubj|regulation -|compound|END_ENTITY	Adenosine_A -LRB- 2A -RRB- _ receptor mRNA regulation by nerve_growth_factor is TrkA - , Src - , and Ras-dependent via extracellular regulated kinase and stress-activated protein kinase/c-Jun NH -LRB- 2 -RRB- - terminal kinase .
10713102	0	nerve_growth_factor	45,64	TrkA	0,4	nerve growth factor	TrkA	4803	4914	Gene	Gene	specificity|nmod|START_ENTITY amino_acids|dobj|specificity amino_acids|nsubj|END_ENTITY	TrkA amino_acids controlling specificity for nerve_growth_factor .
10842245	0	nerve_growth_factor	57,76	TrkA	87,91	nerve growth factor	TrkA	4803	4914	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|compound|END_ENTITY	Neuronal differentiation in human neuroblastoma cells by nerve_growth_factor following TrkA up-regulation by interferon-gamma .
10955718	0	nerve_growth_factor	124,143	TrkA	63,67	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY thymus|nmod|levels thymus|nsubj|Changes Changes|nmod|expression expression|nmod|END_ENTITY	Changes in the expression of the nerve_growth_factor receptors TrkA and p75LNGR in the rat thymus with ageing and increased nerve_growth_factor plasma levels .
11245580	0	nerve_growth_factor	53,72	TrkA	48,52	nerve growth factor	TrkA	18049(Tax:10090)	18211(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	mKlf7 , a potential transcriptional regulator of TrkA nerve_growth_factor receptor expression in sensory and sympathetic neurons .
12011113	0	nerve_growth_factor	35,54	TrkA	55,59	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	Pincher|nmod|START_ENTITY Pincher|parataxis|signaling signaling|nsubj|END_ENTITY	Pincher , a pinocytic_chaperone for nerve_growth_factor / TrkA signaling endosomes .
14663198	0	nerve_growth_factor	60,79	TrkA	52,56	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	impairs|nmod|START_ENTITY impairs|dobj|response response|nmod|END_ENTITY	Loss of cell adhesion impairs the early response of TrkA to nerve_growth_factor -LRB- NGF -RRB- .
15051797	0	nerve_growth_factor	29,48	TrkA	226,230	nerve growth factor	TrkA	4803	4914	Gene	Gene	activity|nmod|START_ENTITY antagonist|nsubj|activity antagonist|parataxis|-4,9 -4,9|dep|-RSB- -RSB-|acl:relcl|suggests suggests|nmod|presence presence|nmod|END_ENTITY	Differential activity of the nerve_growth_factor -LRB- NGF -RRB- antagonist PD90780 -LSB- 7 - -LRB- benzolylamino -RRB- -4,9 - dihydro-4-methyl-9-oxo-pyrazolo -LSB- 5,1-b -RSB- quinazoline-2-carboxylic acid -RSB- suggests altered NGF-p75NTR interactions in the presence of TrkA .
21394800	0	nerve_growth_factor	112,131	TrkA	175,179	nerve growth factor	TrkA	4803	4914	Gene	Gene	fragment|nmod|START_ENTITY +|nmod|fragment +|xcomp|encompassing encompassing|dobj|domain domain|nmod|receptor receptor|compound|END_ENTITY	The inorganic perspective of nerve_growth_factor : interactions of Cu2 + and Zn2 + with the N-terminus fragment of nerve_growth_factor encompassing the recognition domain of the TrkA receptor .
21394800	0	nerve_growth_factor	29,48	TrkA	175,179	nerve growth factor	TrkA	4803	4914	Gene	Gene	perspective|nmod|START_ENTITY perspective|dep|interactions interactions|nmod|+ +|acl|+ +|xcomp|encompassing encompassing|dobj|domain domain|nmod|receptor receptor|compound|END_ENTITY	The inorganic perspective of nerve_growth_factor : interactions of Cu2 + and Zn2 + with the N-terminus fragment of nerve_growth_factor encompassing the recognition domain of the TrkA receptor .
26738323	0	nerve_growth_factor	25,44	TrkA	54,58	nerve growth factor	TrkA	4803	4914	Gene	Gene	ratio|nmod|START_ENTITY receptor|nsubj|ratio receptor|dobj|END_ENTITY	-LSB- Expression ratio of the nerve_growth_factor receptor TrkA to p75NTR correlates with the clinical stage and pathological grade of prostate_cancer -RSB- .
7543930	0	nerve_growth_factor	56,75	TrkA	34,38	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY levels|nmod|cells levels|nmod|END_ENTITY	Multiple levels for regulation of TrkA in PC12 cells by nerve_growth_factor .
7896793	0	nerve_growth_factor	24,43	TrkA	49,53	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Small peptide mimics of nerve_growth_factor bind TrkA receptors and affect biological responses .
8170995	0	nerve_growth_factor	57,76	TrkA	14,18	nerve growth factor	TrkA	4803	4914	Gene	Gene	confers|xcomp|START_ENTITY confers|nsubj|Expression Expression|nmod|END_ENTITY	Expression of TrkA confers neuron-like responsiveness to nerve_growth_factor on an immortalized hypothalamic cell line .
8987823	0	nerve_growth_factor	45,64	TrkA	25,29	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY evidence|dep|induces Endocytosis|dep|evidence Endocytosis|nmod|END_ENTITY	Endocytosis of activated TrkA : evidence that nerve_growth_factor induces formation of signaling endosomes .
9083066	0	nerve_growth_factor	43,62	TrkA	105,109	nerve growth factor	TrkA	4803	4914	Gene	Gene	molecule|compound|START_ENTITY surface|nmod|molecule sites|nmod|surface determine|nsubj|sites determine|dobj|receptor receptor|compound|END_ENTITY	Two restricted sites on the surface of the nerve_growth_factor molecule independently determine specific TrkA receptor binding and activation .
9166727	0	nerve_growth_factor	38,57	TrkA	81,85	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	START_ENTITY|nmod|dimer dimer|nmod|END_ENTITY	Ganglioside GM1 enhances induction by nerve_growth_factor of a putative dimer of TrkA .
9219271	0	nerve_growth_factor	39,58	TrkA	79,83	nerve growth factor	TrkA	4803	4914	Gene	Gene	site|compound|START_ENTITY site|nmod|receptor receptor|compound|END_ENTITY	Immunoglobulin-like domains define the nerve_growth_factor binding site of the TrkA receptor .
9514198	0	nerve_growth_factor	26,45	TrkA	90,94	nerve growth factor	TrkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	signaling|compound|START_ENTITY Duration|nmod|signaling depend|nsubj|Duration depend|nmod|END_ENTITY	Duration and magnitude of nerve_growth_factor signaling depend on the ratio of p75LNTR to TrkA .
7052505	0	nerve_growth_factor	38,57	acetylcholinesterase	14,34	nerve growth factor	acetylcholinesterase	310738(Tax:10116)	83817(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of acetylcholinesterase by nerve_growth_factor in the pheochromocytoma PC12 cell line .
6186950	0	nerve_growth_factor	20,39	albumin	50,57	nerve growth factor	albumin	18049(Tax:10090)	11657(Tax:10090)	Gene	Gene	transport|nmod|START_ENTITY END_ENTITY|nsubj|transport	Axonal transport of nerve_growth_factor and serum albumin in the dystrophic_mouse .
9220450	0	nerve_growth_factor	58,77	bcl-2	38,43	nerve growth factor	bcl-2	4803	596	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Autocrine regulation of apoptosis and bcl-2 expression by nerve_growth_factor in early differentiating cerebellar granule neurons involves low affinity neurotrophin receptor .
9302089	0	nerve_growth_factor	23,42	bcl-2	77,82	nerve growth factor	bcl-2	310738(Tax:10116)	24224(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY result|nsubj|effect result|nmod|up-regulation up-regulation|nmod|cells cells|amod|END_ENTITY	The rescuing effect of nerve_growth_factor is the result of up-regulation of bcl-2 in hyperoxia-induced apoptosis of a subclone of pheochromocytoma cells , PC12h .
22280975	0	nerve_growth_factor	74,93	brain-derived_neurotrophic_factor	97,130	nerve growth factor	brain-derived neurotrophic factor	310738(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Selective inhibition of extracellular_signal-regulated_kinases_1 / 2 blocks nerve_growth_factor to brain-derived_neurotrophic_factor signaling and suppresses the development of and reverses already established pain behavior in rats .
8361625	0	nerve_growth_factor	48,67	c-JUN	39,44	nerve growth factor	c-JUN	4803	3725	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the transcription factor c-JUN by nerve_growth_factor in adult sensory neurons .
15823252	0	nerve_growth_factor	26,45	calcitonin_gene-related_peptide	49,80	nerve growth factor	calcitonin gene-related peptide	4803	796	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	The effect of endoneurial nerve_growth_factor on calcitonin_gene-related_peptide expression in primary sensory neurons .
20973063	0	nerve_growth_factor	11,30	calcitonin_gene-related_peptide	62,93	nerve growth factor	calcitonin gene-related peptide	310738(Tax:10116)	24241(Tax:10116)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expression expression|amod|END_ENTITY	Inhibiting nerve_growth_factor or its receptors downregulates calcitonin_gene-related_peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs .
1515953	0	nerve_growth_factor	33,52	choline_acetyltransferase	56,81	nerve growth factor	choline acetyltransferase	310738(Tax:10116)	290567(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of delayed treatment with nerve_growth_factor on choline_acetyltransferase activity in the cortex of rats with lesions of the nucleus basalis magnocellularis : dose requirements .
2790481	0	nerve_growth_factor	87,106	choline_acetyltransferase	33,58	nerve growth factor	choline acetyltransferase	18049(Tax:10090)	12647(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|stimulation stimulation|nmod|activity activity|amod|END_ENTITY	Axotomy-dependent stimulation of choline_acetyltransferase activity by exogenous mouse nerve_growth_factor in adult rat basal forebrain .
8405259	0	nerve_growth_factor	17,36	choline_acetyltransferase	54,79	nerve growth factor	choline acetyltransferase	310738(Tax:10116)	290567(Tax:10116)	Gene	Gene	enhancement|nmod:poss|START_ENTITY Reversibility|nmod|enhancement Reversibility|nmod|activity activity|amod|END_ENTITY	Reversibility of nerve_growth_factor 's enhancement of choline_acetyltransferase activity in cultured embryonic rat septum .
8592155	0	nerve_growth_factor	24,43	choline_acetyltransferase	61,86	nerve growth factor	choline acetyltransferase	310738(Tax:10116)	290567(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|transport transport|compound|END_ENTITY	Differential effects of nerve_growth_factor on expression of choline_acetyltransferase and sodium-coupled choline transport in basal forebrain cholinergic neurons in culture .
8843027	0	nerve_growth_factor	68,87	decay_accelerating_factor	32,57	nerve growth factor	decay accelerating factor	4803	1604	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Activation of the gene encoding decay_accelerating_factor following nerve_growth_factor treatment of sensory neurons is mediated by promoter sequences within 206 bases of the transcriptional start site .
23408790	0	nerve_growth_factor	16,35	glial_fibrillary_acidic_protein	57,88	nerve growth factor	glial fibrillary acidic protein	18049(Tax:10090)	14580(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of mouse nerve_growth_factor on the expression of glial_fibrillary_acidic_protein in hippocampus of neonatal rats with hypoxic-ischemic_brain_damage .
10842245	0	nerve_growth_factor	57,76	interferon-gamma	109,125	nerve growth factor	interferon-gamma	4803	3458	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Neuronal differentiation in human neuroblastoma cells by nerve_growth_factor following TrkA up-regulation by interferon-gamma .
1333537	0	nerve_growth_factor	14,33	interleukin-1_beta	53,71	nerve growth factor	interleukin-1 beta	4803	3553	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Mechanisms of nerve_growth_factor mRNA regulation by interleukin-1_beta in hippocampal cultures : role of second messengers .
7582555	0	nerve_growth_factor	75,94	interleukin-1_beta	16,34	nerve growth factor	interleukin-1 beta	4803	3553	Gene	Gene	increase|nmod|START_ENTITY END_ENTITY|nmod|increase	Contribution of interleukin-1_beta to the inflammation-induced increase in nerve_growth_factor levels and inflammatory_hyperalgesia .
8056439	0	nerve_growth_factor	81,100	interleukin-1_beta	134,152	nerve growth factor	interleukin-1 beta	310738(Tax:10116)	3553	Gene	Gene	regulation|compound|START_ENTITY study|nmod|regulation system|nmod|study system|parataxis|additive additive|nsubj|stimulation stimulation|acl|END_ENTITY	The immortalized astroglial cell line RC7 is a new model system for the study of nerve_growth_factor -LRB- NGF -RRB- regulation : stimulation by interleukin-1_beta and transforming_growth_factor-beta_1 is additive and affected differently by dibutyryl_cyclic_AMP .
2026175	0	nerve_growth_factor	68,87	microtubule_associated_protein_2	14,46	nerve growth factor	microtubule associated protein 2	310738(Tax:10116)	25595(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of microtubule_associated_protein_2 -LRB- MAP2 -RRB- expression by nerve_growth_factor in PC12 cells .
26347141	0	nerve_growth_factor	55,74	myelin_oligodendrocyte_glycoprotein	4,39	nerve growth factor	myelin oligodendrocyte glycoprotein	18049(Tax:10090)	17441(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The myelin_oligodendrocyte_glycoprotein directly binds nerve_growth_factor to modulate central axon circuitry .
2160601	0	nerve_growth_factor	57,76	neuropeptide_Y	34,48	nerve growth factor	neuropeptide Y	310738(Tax:10116)	24604(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the neuropeptide_Y gene by nerve_growth_factor : antagonism by glucocorticoids and potentiation by adenosine_3 ' ,5 ' - monophosphate and phorbol_ester .
8195188	0	nerve_growth_factor	63,82	neuropeptide_Y	40,54	nerve growth factor	neuropeptide Y	4803	4852	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the human neuropeptide_Y gene by nerve_growth_factor .
1547788	0	nerve_growth_factor	74,93	neurotrophin-3	11,25	nerve growth factor	neurotrophin-3	396466(Tax:9031)	428099(Tax:9031)	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|receptors receptors|amod|END_ENTITY	Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve_growth_factor and brain-derived_neurotrophic_factor .
17698064	0	nerve_growth_factor	21,40	neurotrophin-3	79,93	nerve growth factor	neurotrophin-3	4803	4908	Gene	Gene	folding|nmod|START_ENTITY mediated|nsubjpass|folding mediated|nmod|pro-peptide pro-peptide|nmod|END_ENTITY	Oxidative folding of nerve_growth_factor can be mediated by the pro-peptide of neurotrophin-3 .
7603624	0	nerve_growth_factor	116,135	neurotrophin-3	14,28	nerve growth factor	neurotrophin-3	310738(Tax:10116)	81737(Tax:10116)	Gene	Gene	distinct|nmod|START_ENTITY show|xcomp|distinct show|nsubj|levels levels|nmod|protein protein|amod|END_ENTITY	The levels of neurotrophin-3 protein in the rat brain determined by enzyme immunoassay show a pattern distinct from nerve_growth_factor .
8163724	0	nerve_growth_factor	91,110	neurotrophin-3	51,65	nerve growth factor	neurotrophin-3	310738(Tax:10116)	81737(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Embryonic sensory development : local expression of neurotrophin-3 and target expression of nerve_growth_factor .
10605940	0	nerve_growth_factor	11,30	nicotinic_acetylcholine_receptor	65,97	nerve growth factor	nicotinic acetylcholine receptor	310738(Tax:10116)	170945(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of nerve_growth_factor and nicotine on the expression of nicotinic_acetylcholine_receptor subunits in PC12 cells .
10888742	0	nerve_growth_factor	10,29	p75	96,99	nerve growth factor	p75	18049(Tax:10090)	18053(Tax:10090)	Gene	Gene	Levels|nmod|START_ENTITY affected|nsubjpass|Levels affected|nmod|presence presence|nmod|END_ENTITY	Levels of nerve_growth_factor and neurotrophin-3 are affected differentially by the presence of p75 in sympathetic neurons in vivo .
11042591	0	nerve_growth_factor	39,58	p75	11,14	nerve growth factor	p75	18049(Tax:10090)	18053(Tax:10090)	Gene	Gene	immunolocalization|compound|START_ENTITY reduces|dobj|immunolocalization reduces|nsubj|Absence Absence|nmod|expression expression|compound|END_ENTITY	Absence of p75 -LRB- NTR -RRB- expression reduces nerve_growth_factor immunolocalization in cholinergic septal neurons .
11435417	0	nerve_growth_factor	107,126	p75	49,52	nerve growth factor	p75	4803	7133	Gene	Gene	binding|nmod|START_ENTITY regulate|xcomp|binding regulate|nsubj|domains domains|nmod|receptors receptors|compound|END_ENTITY	The cytoplasmic and transmembrane domains of the p75 and Trk_A receptors regulate high affinity binding to nerve_growth_factor .
12671996	0	nerve_growth_factor	31,50	p75	117,120	nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY arrest|nmod|cells dependent|nsubj|arrest dependent|nmod|pathway pathway|nmod|receptor receptor|amod|END_ENTITY	Growth arrest of PC12 cells by nerve_growth_factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor .
1424101	0	nerve_growth_factor	148,167	p75	37,40	nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	antibodies|nmod|START_ENTITY density|nmod|antibodies density|nmod|receptors receptors|amod|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat spinal cord as a function of age and treatment with antibodies to nerve_growth_factor .
1424101	0	nerve_growth_factor	41,60	p75	37,40	nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat spinal cord as a function of age and treatment with antibodies to nerve_growth_factor .
1446237	0	nerve_growth_factor	142,161	p75	37,40	nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	antibodies|nmod|START_ENTITY density|nmod|antibodies density|nmod|receptors receptors|amod|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat brain as a function of age and treatment with antibodies to nerve_growth_factor .
1446237	0	nerve_growth_factor	41,60	p75	37,40	nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat brain as a function of age and treatment with antibodies to nerve_growth_factor .
15131306	0	nerve_growth_factor	13,32	p75	81,84	nerve growth factor	p75	4803	7133	Gene	Gene	Structure|nmod|START_ENTITY complexed|nsubj|Structure complexed|nmod|END_ENTITY	Structure of nerve_growth_factor complexed with the shared neurotrophin receptor p75 .
16763091	0	nerve_growth_factor	129,148	p75	125,128	nerve growth factor	p75	4803	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Penta-acetyl_geniposide induce apoptosis in C6 glioma cells by modulating the activation of neutral_sphingomyelinase-induced p75 nerve_growth_factor receptor and protein kinase Cdelta pathway .
19210757	0	nerve_growth_factor	33,52	p75	62,65	nerve growth factor	p75	4803	3560	Gene	Gene	receptor|compound|START_ENTITY Localization|nmod|receptor END_ENTITY|nsubj|Localization	Localization of the low-affinity nerve_growth_factor receptor p75 in human limbal epithelial cells .
7473570	0	nerve_growth_factor	50,69	p75	96,99	nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
8614802	0	nerve_growth_factor	38,57	p75	92,95	nerve growth factor	p75	310738(Tax:10116)	24596(Tax:10116)	Gene	Gene	Selective|nmod|START_ENTITY Selective|nmod|END_ENTITY	Selective activation of NF-kappa B by nerve_growth_factor through the neurotrophin receptor p75 .
9618141	0	nerve_growth_factor	14,33	p75NTR	65,71	nerve growth factor	p75NTR	18049(Tax:10090)	18053(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of nerve_growth_factor and its low-affinity receptor -LRB- p75NTR -RRB- during myogenic differentiation .
11158238	0	nerve_growth_factor	34,53	presenilin-1	18,30	nerve growth factor	presenilin-1	310738(Tax:10116)	29192(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The regulation of presenilin-1 by nerve_growth_factor .
7814416	0	nerve_growth_factor	51,70	protein_tyrosine_phosphatase	11,39	nerve growth factor	protein tyrosine phosphatase	310738(Tax:10116)	24697(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	A neuronal protein_tyrosine_phosphatase induced by nerve_growth_factor .
11710915	0	nerve_growth_factor	87,106	substance_P	29,40	nerve growth factor	substance P	18049(Tax:10090)	21333(Tax:10090)	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	The neurosensory tachykinins substance_P and neurokinin_A directly induce keratinocyte nerve_growth_factor .
8632154	0	nerve_growth_factor	62,81	thrombin	36,44	nerve growth factor	thrombin	4803	2147	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Transduction mechanisms involved in thrombin receptor-induced nerve_growth_factor secretion and cell division in primary cultures of astrocytes .
9202299	0	nerve_growth_factor	116,135	transforming_growth_factor-beta1	80,112	nerve growth factor	transforming growth factor-beta1	4803	7040	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effect of calcitriol in combination with corticosterone , interleukin-1beta , and transforming_growth_factor-beta1 on nerve_growth_factor secretion in an astroglial cell line .
1649007	0	nerve_growth_factor	69,88	trk	4,7	nerve growth factor	trk	18049(Tax:10090)	18211(Tax:10090)	Gene	Gene	properties|nmod|START_ENTITY mediates|dobj|properties mediates|nsubj|kinase kinase|amod|END_ENTITY	The trk tyrosine protein kinase mediates the mitogenic properties of nerve_growth_factor and neurotrophin-3 .
1849459	0	nerve_growth_factor	46,65	trk	4,7	nerve growth factor	trk	310738(Tax:10116)	4914	Gene	Gene	receptor|nmod|START_ENTITY encodes|dobj|receptor encodes|nsubj|proto-oncogene proto-oncogene|compound|END_ENTITY	The trk proto-oncogene encodes a receptor for nerve_growth_factor .
7868185	0	nerve_growth_factor	13,32	trkA	87,91	nerve growth factor	trkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY responsiveness|nsubj|Induction responsiveness|nmod|expression expression|nmod|proto-oncogene proto-oncogene|compound|END_ENTITY	Induction of nerve_growth_factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene .
7985814	0	nerve_growth_factor	25,44	trkA	85,89	nerve growth factor	trkA	4803	4914	Gene	Gene	changes|nmod|START_ENTITY binding|nsubj|changes binding|dobj|proteins proteins|amod|END_ENTITY	Developmental changes in nerve_growth_factor -LRB- NGF -RRB- binding and NGF receptor proteins trkA and p75 in the facial nerve .
8195465	0	nerve_growth_factor	118,137	trkA	35,39	nerve growth factor	trkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	colocalization|nmod|START_ENTITY distribution|acl|colocalization distribution|nmod|detection detection|nmod|mRNA mRNA|compound|END_ENTITY	In situ hybridization detection of trkA mRNA in brain : distribution , colocalization with p75NGFR and up-regulation by nerve_growth_factor .
8847739	0	nerve_growth_factor	8,27	trkA	49,53	nerve growth factor	trkA	310738(Tax:10116)	59109(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Role of nerve_growth_factor in the expression of trkA mRNA in cultured embryonic rat basal forebrain cholinergic neurons .
8940397	0	nerve_growth_factor	15,34	trkA	61,65	nerve growth factor	trkA	4803	4914	Gene	Gene	START_ENTITY|dep|activation activation|compound|END_ENTITY	Involvement of nerve_growth_factor in the ovulatory cascade : trkA receptor activation inhibits gap junctional communication between thecal cells .
9204927	0	nerve_growth_factor	76,95	trkA	4,8	nerve growth factor	trkA	396466(Tax:9031)	396337(Tax:9031)	Gene	Gene	source|nmod|START_ENTITY turning|nmod|source cone|acl|turning mediates|dobj|cone mediates|nsubj|receptor receptor|compound|END_ENTITY	The trkA receptor mediates growth cone turning toward a localized source of nerve_growth_factor .
8895335	0	nerve_growth_factor-induced_gene-B	13,47	NGFI-B	49,55	nerve growth factor-induced gene-B	NGFI-B	403897(Tax:9615)	403897(Tax:9615)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of nerve_growth_factor-induced_gene-B -LRB- NGFI-B -RRB- as an early event in the cyclic_adenosine_monophosphate response of dog thyrocytes in primary culture .
15501594	0	nerve_growth_factor-induced_gene_A	47,81	NGFI-A	83,89	nerve growth factor-induced gene A	NGFI-A	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Postnatal expression of the plasticity-related nerve_growth_factor-induced_gene_A -LRB- NGFI-A -RRB- protein in the superficial layers of the rat superior colliculus : relation to N-methyl-D-aspartate receptor function .
3856258	0	nerve_growth_factor-inducible_large_external_glycoprotein	19,76	NILE	78,82	nerve growth factor-inducible large external glycoprotein	NILE	50687(Tax:10116)	50687(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of the nerve_growth_factor-inducible_large_external_glycoprotein -LRB- NILE -RRB- in neurite_fasciculation in primary cultures of rat brain .
1324502	0	nerve_growth_factor_receptor	35,63	NGFR	65,69	nerve growth factor receptor	NGFR	4804	4804	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of nerve_growth_factor_receptor -LRB- NGFR -RRB- in human teeth .
1846159	0	nerve_growth_factor_receptor	29,57	NGFR	59,63	nerve growth factor receptor	NGFR	24596(Tax:10116)	24596(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Non-radioactive detection of nerve_growth_factor_receptor -LRB- NGFR -RRB- mRNA in rat brain using in situ hybridization histochemistry .
26278479	0	nerve_growth_factor_receptor	41,69	NGFR	71,75	nerve growth factor receptor	NGFR	4804	4804	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional Ser205Leu polymorphism of the nerve_growth_factor_receptor -LRB- NGFR -RRB- gene is associated with vagal autonomic dysregulation in humans .
26278479	0	nerve_growth_factor_receptor	41,69	NGFR	71,75	nerve growth factor receptor	NGFR	4804	4804	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional Ser205Leu polymorphism of the nerve_growth_factor_receptor -LRB- NGFR -RRB- gene is associated with vagal autonomic dysregulation in humans .
7972209	0	nerve_growth_factor_receptor	31,59	TRK-A	61,66	nerve growth factor receptor	TRK-A	4804	4914	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of the nerve_growth_factor_receptor -LRB- TRK-A -RRB- in human neuroblastoma cell lines .
19263582	0	nerve_growth_factor_receptor	69,97	Trk-A	99,104	nerve growth factor receptor	Trk-A	4804	4914	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Effect of acetyl-l-carnitine on ovarian_cancer cells ' proliferation , nerve_growth_factor_receptor -LRB- Trk-A and p75 -RRB- expression , and the cytotoxic potential of paclitaxel and carboplatin .
10708759	0	nerve_growth_factor_receptor	22,50	TrkA	52,56	nerve growth factor receptor	TrkA	4804	4914	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Direct interaction of nerve_growth_factor_receptor , TrkA , with non-receptor tyrosine kinase , c-Abl , through the activation loop .
18719857	0	nerve_growth_factor_receptor	39,67	Zhangfei	0,8	nerve growth factor receptor	Zhangfei	4804	58487	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Zhangfei induces the expression of the nerve_growth_factor_receptor , trkA , in medulloblastoma cells and causes their differentiation or apoptosis .
19016376	0	nerve_growth_factor_receptor	41,69	Zhangfei	0,8	nerve growth factor receptor	Zhangfei	4804	58487	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Zhangfei , a novel regulator of the human nerve_growth_factor_receptor , trkA .
2157470	0	nerve_growth_factor_receptor	52,80	brain-derived_neurotrophic_factor	11,44	nerve growth factor receptor	brain-derived neurotrophic factor	4804	627	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of brain-derived_neurotrophic_factor to the nerve_growth_factor_receptor .
10708759	0	nerve_growth_factor_receptor	22,50	c-Abl	93,98	nerve growth factor receptor	c-Abl	4804	25	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Direct interaction of nerve_growth_factor_receptor , TrkA , with non-receptor tyrosine kinase , c-Abl , through the activation loop .
17910636	0	nerve_growth_factor_receptor	5,33	p75NTR	35,41	nerve growth factor receptor	p75NTR	4804	4804	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	High nerve_growth_factor_receptor -LRB- p75NTR -RRB- expression is a favourable prognostic factor in paediatric B cell precursor-acute_lymphoblastic_leukaemia .
25045015	0	nervous_wreck_2	49,64	Sp4	21,24	nervous wreck 2	Sp4	89848	6671	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor Sp4 regulates expression of nervous_wreck_2 to control NMDAR1 levels and dendrite patterning .
21664420	0	nescient_helix-loop-helix-2	55,82	Melanocortin_4_receptor	0,23	nescient helix-loop-helix-2	Melanocortin 4 receptor	4808	4160	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Melanocortin_4_receptor is a transcriptional target of nescient_helix-loop-helix-2 .
23026212	0	nescient_helix-loop-helix_2	49,76	NHLH2	78,83	nescient helix-loop-helix 2	NHLH2	4808	4808	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two single nucleotide polymorphisms in the human nescient_helix-loop-helix_2 -LRB- NHLH2 -RRB- gene reduce mRNA stability and DNA binding .
20380005	0	nesfatin-1	14,24	NUCB2	25,30	nesfatin-1	NUCB2	59295(Tax:10116)	59295(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of nesfatin-1 / NUCB2 in rodent digestive system .
25344190	0	nesfatin-1	15,25	NUCB2	26,31	nesfatin-1	NUCB2	59295(Tax:10116)	59295(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	-LSB- Expression of nesfatin-1 / NUCB2 and ghrelin in gastric mucosa of rats with intrauterine_growth_retardation -RSB- .
25451467	0	nesfatin-1	54,64	NUCB2	65,70	nesfatin-1	NUCB2	53322(Tax:10090)	53322(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulate|dobj|expression END_ENTITY|dep|regulate	Progesterone and 17b-estradiol regulate expression of nesfatin-1 / NUCB2 in mouse pituitary gland .
26369257	0	nesfatin-1	50,60	NUCB2	0,5	nesfatin-1	NUCB2	4925	4925	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	NUCB2 gene polymorphism and its relationship with nesfatin-1 levels in polycystic_ovary_syndrome .
24829503	0	nesfatin-1	10,20	NucB2	21,26	nesfatin-1	NucB2	59295(Tax:10116)	59295(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role of nesfatin-1 / NucB2 in dehydration-induced anorexia .
20966530	0	nesfatin-1	28,38	corticotropin-releasing_hormone	49,80	nesfatin-1	corticotropin-releasing hormone	59295(Tax:10116)	81648(Tax:10116)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|neurons neurons|amod|END_ENTITY	Stressor-responsive central nesfatin-1 activates corticotropin-releasing_hormone , noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal_axis .
19375463	0	nestin	66,72	Bcl-2	0,5	nestin	Bcl-2	25491(Tax:10116)	24224(Tax:10116)	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Bcl-2 or bcl-XL gene therapy increases neural plasticity proteins nestin and c-fos expression in PC12 cells .
24649049	0	nestin	59,65	Bone_morphogenetic_protein_7	0,28	nestin	Bone morphogenetic protein 7	25491(Tax:10116)	85272(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Bone_morphogenetic_protein_7 upregulates the expression of nestin and glial_fibrillary_acidic_protein in rats with cerebral_ischemia-reperfusion injury .
23000950	0	nestin	48,54	cyclin-dependent_kinase_5	80,105	nestin	cyclin-dependent kinase 5	25491(Tax:10116)	140908(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of intermediate filament protein nestin and its association with cyclin-dependent_kinase_5 in the glomeruli of rats with diabetic_nephropathy .
16571784	0	nestin	61,67	intermediate_filament_protein	31,60	nestin	intermediate filament protein	18008(Tax:10090)	18008(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Differential expression of the intermediate_filament_protein nestin during renal development and its localization in adult podocytes .
11398835	0	nestin	48,54	vimentin	69,77	nestin	vimentin	10763	7431	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of intermediate_filament_protein nestin as related to vimentin and desmin in regenerating skeletal muscle .
11170725	0	netrin-1	14,22	DCC	41,44	netrin-1	DCC	114523(Tax:10116)	25311(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of netrin-1 and its receptors DCC and UNC-5H2 after axotomy and during regeneration of adult rat retinal ganglion cells .
11239160	0	netrin-1	18,26	DCC	11,14	netrin-1	DCC	114523(Tax:10116)	25311(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY Binding|nmod|activation Binding|nmod|END_ENTITY	Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation .
11927147	0	netrin-1	14,22	DCC	46,49	netrin-1	DCC	114523(Tax:10116)	25311(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of netrin-1 and netrin-1 receptor , DCC , in the rat olfactory nerve pathway during development and axonal regeneration .
15730872	0	netrin-1	110,118	DCC	67,70	netrin-1	DCC	9423	1630	Gene	Gene	Localization|amod|START_ENTITY Localization|nmod|immunoreactivity immunoreactivity|nmod|deleted_in_colorectal_cancer deleted_in_colorectal_cancer|appos|END_ENTITY	Localization of immunoreactivity for deleted_in_colorectal_cancer -LRB- DCC -RRB- , the receptor for the guidance factor netrin-1 , in ventral tier dopamine projection pathways in adult rodents .
16337279	0	netrin-1	136,144	DCC	145,148	netrin-1	DCC	114523(Tax:10116)	25311(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis : possible role of the netrin-1 / DCC binding pathway in an autoimmune_PNS_disorder .
16337279	0	netrin-1	23,31	DCC	145,148	netrin-1	DCC	114523(Tax:10116)	25311(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein expression|dep|role role|nmod|pathway pathway|compound|END_ENTITY	Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis : possible role of the netrin-1 / DCC binding pathway in an autoimmune_PNS_disorder .
17334389	0	netrin-1	18,26	DCC	55,58	netrin-1	DCC	9423	1630	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion , tumor growth and metastasis .
17574219	0	netrin-1	14,22	DCC	41,44	netrin-1	DCC	114523(Tax:10116)	25311(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of netrin-1 and its receptors DCC and neogenin in rat brain after ischemia .
18585357	0	netrin-1	88,96	DCC	50,53	netrin-1	DCC	373694(Tax:8355)	378529(Tax:8355)	Gene	Gene	turning|nmod|START_ENTITY mediating|advcl|turning collaborates|advcl|mediating collaborates|nmod|END_ENTITY	DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1 .
23641072	0	netrin-1	41,49	DCC	29,32	netrin-1	DCC	9423	1630	Gene	Gene	couples|xcomp|START_ENTITY couples|nsubj|binding binding|nmod|TUBB3 TUBB3|nmod|END_ENTITY	Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance .
25123307	0	netrin-1	25,33	DCC	50,53	netrin-1	DCC	9423	1630	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue .
25123307	0	netrin-1	85,93	DCC	50,53	netrin-1	DCC	9423	1630	Gene	Gene	cue|amod|START_ENTITY bifunctionality|nmod|cue reveals|dobj|bifunctionality reveals|nsubj|structure structure|nmod|netrin-1 netrin-1|nmod|complex complex|nmod|END_ENTITY	The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue .
25881791	0	netrin-1	27,35	DCC	45,48	netrin-1	DCC	9423	1630	Gene	Gene	receptor|amod|START_ENTITY mechanism|nmod|receptor END_ENTITY|nsubj|mechanism	Signaling mechanism of the netrin-1 receptor DCC in axon guidance .
26882243	0	netrin-1	10,18	DCC	19,22	netrin-1	DCC	9423	1630	Gene	Gene	Targeting|xcomp|START_ENTITY END_ENTITY|dep|Targeting	Targeting netrin-1 / DCC interaction in diffuse large B-cell and mantle_cell_lymphomas .
9427245	0	netrin-1	37,45	DCC	87,90	netrin-1	DCC	373694(Tax:8355)	378529(Tax:8355)	Gene	Gene	gradient|amod|START_ENTITY cones|nmod|gradient Turning|nmod|cones mediated|nsubj|Turning mediated|nmod|END_ENTITY	Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC .
15494733	0	netrin-1	25,33	Focal_adhesion_kinase	0,21	netrin-1	Focal adhesion kinase	9423	5747	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Focal_adhesion_kinase in netrin-1 signaling .
23473031	0	netrin-1	99,107	IRE1a	78,83	netrin-1	IRE1a	9423	2081	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1a degradation of netrin-1 .
18692059	0	netrin-1	20,28	NF-kappaB	0,9	Netrin-1	NF-kappaB	18208(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors .
12149262	0	netrin-1	38,46	Rac1	129,133	netrin-1	Rac1	18208(Tax:10090)	5879	Gene	Gene	DCC|amod|START_ENTITY couples|dobj|DCC couples|nmod|activation activation|nmod|END_ENTITY	The adaptor protein Nck-1 couples the netrin-1 receptor DCC -LRB- deleted in colorectal_cancer -RRB- to the activation of the small GTPase Rac1 through an atypical mechanism .
19755150	0	netrin-1	74,82	Rac1	62,66	netrin-1	Rac1	18208(Tax:10090)	19353(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth .
17995930	0	netrin-1	90,98	UNC5A	137,142	netrin-1	UNC5A	9423	90249	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Netrin-1-independent adenosine A2b receptor activation regulates the response of axons to netrin-1 by controlling cell surface levels of UNC5A receptors .
19826074	0	netrin-1	35,43	UNC5B	62,67	netrin-1	UNC5B	9423	219699	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization and expression of netrin-1 and its receptors UNC5B and DCC in human placenta .
19193855	0	netrin-4	45,53	laminin_gamma1	55,69	netrin-4	laminin gamma1	57764(Tax:10090)	226519(Tax:10090)	Gene	Gene	chain|amod|START_ENTITY chain|amod|END_ENTITY	Discovery of a functional protein complex of netrin-4 , laminin_gamma1 chain , and integrin alpha6beta1 in mouse neural stem cells .
20924101	0	neu	44,47	ErbB-2	37,43	neu	ErbB-2	13866(Tax:10090)	24337(Tax:10116)	Gene	Gene	START_ENTITY|dep|expressing expressing|dobj|END_ENTITY	Mesenchymal stromal cells expressing ErbB-2 / neu elicit protective antibreast tumor immunity in vivo , which is paradoxically suppressed by IFN-gamma and tumor_necrosis_factor-alpha priming .
19931543	0	neu	132,135	ErbB2	125,130	neu	ErbB2	2064	2064	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	The effect of hydrophilic substitutions and anionic lipids upon the transverse positioning of the transmembrane helix of the ErbB2 -LRB- neu -RRB- protein incorporated into model membrane vesicles .
10800094	0	neu	141,144	HER-2	135,140	neu	HER-2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary_tumors in HER-2 / neu transgenic_mice .
11696586	0	neu	112,115	HER-2	106,111	neu	HER-2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Combined_allogeneic_tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2 / neu transgenic_mice .
12691823	0	neu	95,98	HER-2	89,94	neu	HER-2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Number of pregnancies and ovariectomy modify mammary_carcinoma development in transgenic HER-2 / neu female mice .
16224592	0	neu	71,74	HER-2	65,70	neu	HER-2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Metformin decelerates aging and development of mammary_tumors in HER-2 / neu transgenic_mice .
18306859	0	neu	94,97	HER-2	88,93	neu	HER-2	2064	2064	Gene	Gene	confers|nsubj|START_ENTITY END_ENTITY|appos|confers	Recurrent pure mucinous_carcinoma of the breast with mediastinal great vessel invasion : HER-2 / neu confers aggressiveness .
24472145	0	neu	26,29	HER-2	20,25	neu	HER-2	2064	2064	Gene	Gene	Correlation|dep|START_ENTITY Correlation|nmod|END_ENTITY	Correlation between HER-2 / neu -LRB- erbB-2 -RRB- expression level and therapeutic effect of combination treatment with HERCEPTIN and chemotherapeutic agents in gastric_cancer cell lines .
25443643	0	neu	121,124	HER-2	115,120	neu	HER-2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Sidestream dark field videomicroscopy for in vivo evaluation of vascularization and perfusion of mammary_tumors in HER-2 / neu transgenic_mice .
20810050	0	neu	33,36	Her-2	27,32	neu	Her-2	2064	2064	Gene	Gene	association|dep|START_ENTITY association|nmod|END_ENTITY	Age related association of Her-2 / neu with prognostic markers in female breast_carcinoma .
15625017	0	neu	49,52	PI3K	62,66	neu	PI3K	2064	5293	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Downregulation of wild-type p53 protein by HER-2 / neu mediated PI3K pathway activation in human breast_cancer cells : its effect on cell proliferation and implication for therapy .
10619912	0	neu	42,45	c-erbB-2	33,41	neu	c-erbB-2	2064	2064	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Gastric_carcinoma : expression of c-erbB-2 / neu oncoprotein , epidermal_growth_factor_receptor , cathepsin_D , progesterone receptor and tumor associated glycoprotein-72 in different histological types .
2470827	0	neu	16,19	c-erbB-2	21,29	neu	c-erbB-2	2064	2064	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Distribution of neu -LRB- c-erbB-2 -RRB- protein in human skin .
3299059	0	neu	21,24	c-erbB-2	26,34	neu	c-erbB-2	2064	2064	Gene	Gene	oncogene|compound|START_ENTITY oncogene|dep|END_ENTITY	Amplification of the neu -LRB- c-erbB-2 -RRB- oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene .
7870438	0	neu	9,12	c-erbB-2	0,8	neu	c-erbB-2	2064	2064	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	c-erbB-2 / neu oncogene and Ki-67 analysis in the assessment of palatal salivary_gland_neoplasms .
8883464	0	neu	9,12	c-erbB-2	0,8	neu	c-erbB-2	2064	2064	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	c-erbB-2 / neu protein expression , DNA ploidy and S phase in breast_cancer .
10408862	0	neu	8,11	c-erbB2	0,7	neu	c-erbB2	2064	2064	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	c-erbB2 / neu gene and chromosome 17 analysis in breast_cancer by FISH on archival cytological fine-needle aspirates .
11422380	0	neu	28,31	c-erbB2	20,27	neu	c-erbB2	2064	2064	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Transfection of the c-erbB2 / neu gene upregulates the expression of sialyl_Lewis_X , alpha1,3-fucosyltransferase VII , and metastatic potential in a human hepatocarcinoma cell line .
26448177	0	neu	125,128	epidermal_growth_factor_receptor_2	90,124	neu	epidermal growth factor receptor 2	2064	2064	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Loss of FOXO1 promotes gastric_tumour growth and metastasis through upregulation of human epidermal_growth_factor_receptor_2 / neu expression .
1677443	0	neu	54,57	erbB-2	47,53	neu	erbB-2	2064	2064	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Cloning , expression , and biological effects of erbB-2 / neu gene in mammalian cells .
1358436	0	neu	34,37	estrogen_receptor	75,92	neu	estrogen receptor	2064	2099	Gene	Gene	repression|nmod|START_ENTITY protooncogene|nsubj|repression protooncogene|nmod|estrogen estrogen|acl|stimulated stimulated|dobj|END_ENTITY	Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen_receptor .
23255089	0	neu	67,70	estrogen_receptor	14,31	neu	estrogen receptor	2064	2099	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of estrogen_receptor , progesterone_receptor , and Her-2 / _ neu in primary and extra-corporeal endometrial_cancer .
24168506	0	neu	62,65	estrogen_receptor	10,27	neu	Estrogen receptor	2064	2099	Gene	Gene	START_ENTITY|nsubj|Review Review|nmod|progesterone_receptor progesterone_receptor|compound|END_ENTITY	Review of estrogen_receptor , progesterone_receptor , and HER-2 / neu immunohistochemistry impacts on treatment for a small subset of breast_cancer patients transferring care to another institution .
15087404	0	neu	78,81	her-2	72,77	neu	her-2	13866(Tax:10090)	13866(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|amod|END_ENTITY	Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2 / neu transgenic_mice .
1978329	0	neu	64,67	p185	85,89	neu	p185	2064	8661	Gene	Gene	domain|nmod|START_ENTITY structure|nmod|domain Correlation|nmod|structure oncogene-encoded|nsubj|Correlation oncogene-encoded|dobj|protein protein|amod|END_ENTITY	Correlation of the structure of the transmembrane domain of the neu oncogene-encoded p185 protein with its function .
2451200	0	neu	60,63	p185	81,85	neu	p185	13866(Tax:10090)	66515(Tax:10090)	Gene	Gene	effects|compound|START_ENTITY effects|amod|END_ENTITY	Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo .
2566965	0	neu	80,83	p185	102,106	neu	p185	13866(Tax:10090)	8661	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Generation and characterization of monoclonal antibodies specific for the human neu oncogene product , p185 .
2576207	0	neu	110,113	p185	131,135	neu	p185	2064	8661	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Conformational changes induced by the transforming amino_acid substitution in the transmembrane domain of the neu oncogene-encoded p185 protein .
16216242	0	neu1	54,58	lysosomal_sialidase	33,52	neu1	lysosomal sialidase	18010(Tax:10090)	18010(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of MyoD-inducible lysosomal_sialidase -LRB- neu1 -RRB- inhibits myogenesis in C2C12 cells .
1681805	0	neu_protein-specific_activating_factor	36,74	ATL-2	86,91	neu protein-specific activating factor	ATL-2	3576	64225	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	Isolation and characterization of a neu_protein-specific_activating_factor from human ATL-2 cell conditioned medium .
7591845	0	neural_calcium-binding_proteins	30,61	NCS-1	63,68	neural calcium-binding proteins	NCS-1	396336(Tax:9031)	396336(Tax:9031)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Distribution pattern of three neural_calcium-binding_proteins -LRB- NCS-1 , VILIP and recoverin -RRB- in chicken , bovine and rat retina .
19741142	0	neural_cell_adhesion_molecule	59,88	GDNF	211,215	neural cell adhesion molecule	GDNF	4684	2668	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	Role of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- - neural_cell_adhesion_molecule -LRB- NCAM -RRB- interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF .
18353777	0	neural_cell_adhesion_molecule	38,67	GFRalpha1	14,23	neural cell adhesion molecule	GFRalpha1	4684	2674	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Insights into GFRalpha1 regulation of neural_cell_adhesion_molecule -LRB- NCAM -RRB- function from structure-function analysis of the NCAM/GFRalpha1 receptor complex .
12229933	0	neural_cell_adhesion_molecule	16,45	N-CAM	47,52	neural cell adhesion molecule	N-CAM	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of neural_cell_adhesion_molecule -LRB- N-CAM -RRB- immunoreactivity in adult rat tissues .
1551227	0	neural_cell_adhesion_molecule	33,62	N-CAM	64,69	neural cell adhesion molecule	N-CAM	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abnormal expression of embryonic neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in the developing mouse cerebellum after neonatal administration of cytosine_arabinoside .
3025862	0	neural_cell_adhesion_molecule	20,49	N-CAM	51,56	neural cell adhesion molecule	N-CAM	428253(Tax:9031)	428253(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Organization of the neural_cell_adhesion_molecule -LRB- N-CAM -RRB- gene : alternative exon usage as the basis for different membrane-associated domains .
8581955	0	neural_cell_adhesion_molecule	14,43	N-CAM	45,50	neural cell adhesion molecule	N-CAM	4684	4684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in perisinusoidal stellate cells of the human liver .
8701984	0	neural_cell_adhesion_molecule	33,62	N-CAM	64,69	neural cell adhesion molecule	N-CAM	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cell-type-specific expression of neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in Ito cells of rat liver .
9436925	0	neural_cell_adhesion_molecule	36,65	N-CAM	67,72	neural cell adhesion molecule	N-CAM	4684	4684	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential gene expression of the neural_cell_adhesion_molecule -LRB- N-CAM -RRB- in a panel of multiple_myeloma cell lines .
2183016	0	neural_cell_adhesion_molecule	21,50	N-myc	0,5	neural cell adhesion molecule	N-myc	24586(Tax:10116)	298894(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	N-myc down regulates neural_cell_adhesion_molecule expression in rat neuroblastoma .
10222420	0	neural_cell_adhesion_molecule	130,159	NCAM	161,165	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Paucity of retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- nuclear immunostaining in gliomas and inability of retinoic_acid to influence neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression .
12502709	0	neural_cell_adhesion_molecule	30,59	NCAM	61,65	neural cell adhesion molecule	NCAM	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY ligand|appos|END_ENTITY	A synthetic peptide ligand of neural_cell_adhesion_molecule -LRB- NCAM -RRB- , C3d , promotes neuritogenesis and synaptogenesis and modulates presynaptic function in primary cultures of rat hippocampal neurons .
1336835	0	neural_cell_adhesion_molecule	23,52	NCAM	54,58	neural cell adhesion molecule	NCAM	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gradient expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- in the pontine migratory stream of fetal rats .
1373000	0	neural_cell_adhesion_molecule	21,50	NCAM	52,56	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A supportive role of neural_cell_adhesion_molecule -LRB- NCAM -RRB- in adhesion between leukaemic blasts and cytotoxic lymphocytes .
1560678	0	neural_cell_adhesion_molecule	18,47	NCAM	49,53	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- on the haemopoietic cell line Nalm-16 .
1811057	0	neural_cell_adhesion_molecule	20,49	NCAM	51,55	neural cell adhesion molecule	NCAM	428253(Tax:9031)	428253(Tax:9031)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- during heart development .
1856291	0	neural_cell_adhesion_molecule	14,43	NCAM	45,49	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- isoforms in neuroblastoma .
18706130	0	neural_cell_adhesion_molecule	127,156	NCAM	158,162	neural cell adhesion molecule	NCAM	24586(Tax:10116)	24586(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The antidepressant agomelatine blocks the adverse effects of stress on memory and enables spatial learning to rapidly increase neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression in the hippocampus of rats .
19741142	0	neural_cell_adhesion_molecule	59,88	NCAM	90,94	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Role of glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- - neural_cell_adhesion_molecule -LRB- NCAM -RRB- interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF .
1974882	0	neural_cell_adhesion_molecule	77,106	NCAM	108,112	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic linkage of the human apolipoprotein AI-CIII-AIV gene cluster and the neural_cell_adhesion_molecule -LRB- NCAM -RRB- gene .
20003620	0	neural_cell_adhesion_molecule	12,41	NCAM	43,47	neural cell adhesion molecule	NCAM	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- in amygdalo-hippocampal interactions and salience determination of contextual fear memory .
2121537	0	neural_cell_adhesion_molecule	31,60	NCAM	61,65	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Differential expression of the neural_cell_adhesion_molecule NCAM 140 in human pituitary_tumors .
23377853	0	neural_cell_adhesion_molecule	37,66	NCAM	68,72	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of serine 774 of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- is involved in the interaction with collapsin_response_mediator_protein-2 .
2786812	0	neural_cell_adhesion_molecule	44,73	NCAM	75,79	neural cell adhesion molecule	NCAM	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmentally regulated expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- by mouse thymocytes .
3525283	0	neural_cell_adhesion_molecule	13,42	NCAM	44,48	neural cell adhesion molecule	NCAM	397762(Tax:8355)	397762(Tax:8355)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of neural_cell_adhesion_molecule -LRB- NCAM -RRB- in Xenopus embryos .
7527744	0	neural_cell_adhesion_molecule	20,49	NCAM	51,55	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Characterization of neural_cell_adhesion_molecule -LRB- NCAM -RRB- expression in thyroid follicular cells : induction by cytokines and over-expression in autoimmune glands .
7577443	0	neural_cell_adhesion_molecule	27,56	NCAM	58,62	neural cell adhesion molecule	NCAM	428253(Tax:9031)	428253(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- during osteogenesis and secondary chondrogenesis in the embryonic chick .
7833118	0	neural_cell_adhesion_molecule	30,59	NCAM	61,65	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Tissue-specific expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- may allow differential diagnosis of neuroblastoma from embryonal_rhabdomyosarcoma .
7842299	0	neural_cell_adhesion_molecule	18,47	NCAM	49,53	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- in Alzheimer 's _ disease .
8121388	0	neural_cell_adhesion_molecule	19,48	NCAM	50,54	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	-LSB- The expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- , neural_invasion and recurrence patterns in rectal_cancer -- a study using anti-NACM -LRB- neural_cell_adhesion_molecule -RRB- antibody -RSB- .
8214621	0	neural_cell_adhesion_molecule	18,47	NCAM	49,53	neural cell adhesion molecule	NCAM	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- during second - and third-molar development in the mouse .
8313157	0	neural_cell_adhesion_molecule	23,52	NCAM	54,58	neural cell adhesion molecule	NCAM	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Age-related changes in neural_cell_adhesion_molecule -LRB- NCAM -RRB- isoforms in the mouse telencephalon .
8470821	0	neural_cell_adhesion_molecule	14,43	NCAM	45,49	neural cell adhesion molecule	NCAM	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- during the first molar development in the mouse .
8605739	0	neural_cell_adhesion_molecule	20,49	NCAM	14,18	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of NCAM -LRB- neural_cell_adhesion_molecule -RRB- in mitochondrial_myopathy .
9045989	0	neural_cell_adhesion_molecule	20,49	NCAM	51,55	neural cell adhesion molecule	NCAM	17967(Tax:10090)	17967(Tax:10090)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of the neural_cell_adhesion_molecule -LRB- NCAM -RRB- during pre - and postnatal development of mouse incisors .
9215735	0	neural_cell_adhesion_molecule	14,43	NCAM	45,49	neural cell adhesion molecule	NCAM	4684	4684	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of neural_cell_adhesion_molecule -LRB- NCAM -RRB- characterizes a subpopulation of type 1 astrocytes in human optic nerve head .
9226371	0	neural_cell_adhesion_molecule	25,54	NCAM2	61,66	neural cell adhesion molecule	NCAM2	4684	4685	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning of a novel human neural_cell_adhesion_molecule gene -LRB- NCAM2 -RRB- that maps to chromosome region 21q21 and is potentially involved in Down syndrome .
21691800	0	neural_cell_adhesion_molecule	78,107	amyloid_precursor_protein	25,50	neural cell adhesion molecule	amyloid precursor protein	4684	351	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Selective interaction of amyloid_precursor_protein with different isoforms of neural_cell_adhesion_molecule .
16709412	0	neural_cell_adhesion_molecule	4,33	fibroblast_growth_factor_receptor_2	43,78	neural cell adhesion molecule	fibroblast growth factor receptor 2	4684	2263	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The neural_cell_adhesion_molecule binds to fibroblast_growth_factor_receptor_2 .
1438217	0	neural_cell_adhesion_molecule	17,46	osteogenic_protein_1	75,95	neural cell adhesion molecule	osteogenic protein 1	17967(Tax:10090)	12162(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of the neural_cell_adhesion_molecule and neuronal_aggregation by osteogenic_protein_1 .
15883837	0	neural_cell_adhesion_molecule_1	12,43	NCAM1	50,55	neural cell adhesion molecule 1	NCAM1	4684	4684	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	SNPs in the neural_cell_adhesion_molecule_1 gene -LRB- NCAM1 -RRB- may be associated with human neural_tube_defects .
1704192	0	neural_cell_adhesion_molecules	23,53	cytotactin	68,78	neural cell adhesion molecules	cytotactin	4684	3371	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of neural_cell_adhesion_molecules and tenascin -LRB- cytotactin -RRB- during wound healing .
12617830	0	neural_epidermal_growth_factor-like_like_2	11,53	NELL2	55,60	neural epidermal growth factor-like like 2	NELL2	4753	4753	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Restricted neural_epidermal_growth_factor-like_like_2 -LRB- NELL2 -RRB- expression during muscle and neuronal differentiation .
14516654	0	neural_epidermal_growth_factor-like_like_2	11,53	NELL2	55,60	neural epidermal growth factor-like like 2	NELL2	4753	4753	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Restricted neural_epidermal_growth_factor-like_like_2 -LRB- NELL2 -RRB- expression during muscle and neuronal differentiation .
3201756	0	neuraminidase	73,86	Fab	111,114	neuraminidase	Fab	4758	2187	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	Crystallization and preliminary X-ray analysis of type B influenza virus neuraminidase complexed with antibody Fab fragments .
19121622	0	neuraminidase	10,23	IL-8	34,38	neuraminidase	IL-8	4758	3576	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|production production|compound|END_ENTITY	Bacterial neuraminidase increases IL-8 production in lung epithelial cells via NF-kappaB-dependent pathway .
11865415	0	neuraminidase	26,39	NA	41,43	neuraminidase	NA	4758	4758	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Accumulation of defective neuraminidase -LRB- NA -RRB- genes by influenza A viruses in the presence of NA inhibitors as a marker of reduced dependence on NA .
22808012	0	neuraminidase	60,73	NA	75,77	neuraminidase	NA	4758	4758	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Evolutionary history and phylodynamics of influenza A and B neuraminidase -LRB- NA -RRB- genes inferred from large-scale sequence analyses .
23100800	0	neuraminidase	12,25	NA	27,29	neuraminidase	NA	4758	4758	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Efficacy of neuraminidase -LRB- NA -RRB- inhibitors against H1N1 strains of different geographical regions : an in silico approach .
24564719	0	neuraminidase	107,120	Neuraminidase	58,71	neuraminidase	Neuraminidase	4758	4758	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Structural analysis of the novel influenza A -LRB- H7N9 -RRB- viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir , Zanamivir , and Peramivir in the presence of mutation R289K .
7093528	0	neuraminidase	11,24	O2_and_H2O2	58,69	neuraminidase	O2 and H2O2	4758	28893	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of neuraminidase on O2 consumption and release of O2_and_H2O2 from phagocytosing human polymorphonuclear leukocytes .
167833	0	neuraminidase	71,84	alpha-galactosidase_A	26,47	neuraminidase	alpha-galactosidase A	4758	2717	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of human alpha-galactosidase_A and B before and after neuraminidase treatment .
24662240	0	neuraminidase	57,70	angiotensin-converting_enzyme_2	18,49	neuraminidase	angiotensin-converting enzyme 2	4758	59272	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Downregulation of angiotensin-converting_enzyme_2 by the neuraminidase protein of influenza_A _ -LRB- H1N1 -RRB- _ virus .
18065262	0	neuraminidase	120,133	neuraminidase	28,41	neuraminidase	neuraminidase	4758	4758	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Impact of influenza_A_virus neuraminidase mutations on the stability , activity , and sensibility of the neuraminidase to neuraminidase inhibitors .
18065262	0	neuraminidase	28,41	neuraminidase	120,133	neuraminidase	neuraminidase	4758	4758	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	Impact of influenza_A_virus neuraminidase mutations on the stability , activity , and sensibility of the neuraminidase to neuraminidase inhibitors .
2483778	0	neuraminidase	26,39	neuraminidase	57,70	neuraminidase	neuraminidase	4758	4758	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	-LSB- Antigenic specificity of neuraminidase and structure of neuraminidase gene of influenza A -LRB- H1N1 -RRB- serotype Hsw1N1 viruses isolated from man and animals -RSB- .
2483778	0	neuraminidase	57,70	neuraminidase	26,39	neuraminidase	neuraminidase	4758	4758	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	-LSB- Antigenic specificity of neuraminidase and structure of neuraminidase gene of influenza A -LRB- H1N1 -RRB- serotype Hsw1N1 viruses isolated from man and animals -RSB- .
26436118	0	neuraminidase	113,126	neuraminidase	62,75	neuraminidase	neuraminidase	4758	4758	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	In-silico structural analysis of the influenza_A subtype H7N9 neuraminidase and molecular docking with different neuraminidase inhibitors .
26436118	0	neuraminidase	62,75	neuraminidase	113,126	neuraminidase	neuraminidase	4758	4758	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	In-silico structural analysis of the influenza_A subtype H7N9 neuraminidase and molecular docking with different neuraminidase inhibitors .
3533157	0	neuraminidase	116,129	neuraminidase	36,49	neuraminidase	neuraminidase	4758	4758	Gene	Gene	that|nmod|START_ENTITY END_ENTITY|nmod|that	Characterization of influenza virus neuraminidase with hemagglutinin activity and its comparison with that of viral neuraminidase .
3533157	0	neuraminidase	36,49	neuraminidase	116,129	neuraminidase	neuraminidase	4758	4758	Gene	Gene	START_ENTITY|nmod|that that|nmod|END_ENTITY	Characterization of influenza virus neuraminidase with hemagglutinin activity and its comparison with that of viral neuraminidase .
6133438	0	neuraminidase	32,45	neuraminidase	85,98	neuraminidase	neuraminidase	4758	4758	Gene	Gene	START_ENTITY|nmod|test test|compound|END_ENTITY	Simple detection of mumps_virus neuraminidase and anti-neuraminidase with the lectin neuraminidase test .
6133438	0	neuraminidase	85,98	neuraminidase	32,45	neuraminidase	neuraminidase	4758	4758	Gene	Gene	test|compound|START_ENTITY END_ENTITY|nmod|test	Simple detection of mumps_virus neuraminidase and anti-neuraminidase with the lectin neuraminidase test .
23391804	0	neuraminidase-1	23,38	NEU1	40,44	neuraminidase-1	NEU1	4758	4758	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations in the neuraminidase-1 -LRB- NEU1 -RRB- gene in two patients of sialidosis in India .
23520133	0	neuraminidase_1	44,59	insulin	23,30	neuraminidase 1	insulin	4758	3630	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Positive regulation of insulin signaling by neuraminidase_1 .
21036040	0	neuraminidase_3	20,35	NEU3	37,41	neuraminidase 3	NEU3	10825	10825	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of human neuraminidase_3 -LRB- NEU3 -RRB- by C9-triazole derivatives of 2,3-didehydro-N-acetyl-neuraminic _ acid .
19218461	0	neuregulin-1	69,81	Connexin_32	0,11	neuregulin-1	Connexin 32	211323(Tax:10090)	14618(Tax:10090)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Connexin_32 increases the proliferative response of Schwann cells to neuregulin-1 -LRB- Nrg1 -RRB- .
12838503	0	neuregulin-1	31,43	ErbB	44,48	neuregulin-1	ErbB	3084	1956	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Constitutive activation of the neuregulin-1 / ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line .
15897877	0	neuregulin-1	18,30	ErbB	31,35	neuregulin-1	ErbB	3084	1956	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|promotes promotes|nsubj|signaling signaling|compound|END_ENTITY	Activation of the neuregulin-1 / ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant_peripheral_nerve_sheath_tumors .
16432850	0	neuregulin-1	13,25	ErbB	26,30	neuregulin-1	ErbB	3084	1956	Gene	Gene	START_ENTITY|parataxis|contributes contributes|nsubj|signaling signaling|compound|END_ENTITY	Constitutive neuregulin-1 / ErbB signaling contributes to human vestibular_schwannoma proliferation .
17709650	0	neuregulin-1	8,20	ErbB	21,25	neuregulin-1	ErbB	3084	1956	Gene	Gene	Role|nmod|START_ENTITY Role|dep|signaling signaling|compound|END_ENTITY	Role of neuregulin-1 / ErbB signaling in cardiovascular physiology and disease : implications for therapy of heart_failure .
20682778	0	neuregulin-1	120,132	ErbB	133,137	neuregulin-1	ErbB	3084	1956	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Direct binding of the EGF-like domain of neuregulin-1 to integrins -LRB- -LCB- alpha -RCB- v -LCB- beta -RCB- 3_and _ -LCB- alpha -RCB- 6 -LCB- beta -RCB- 4 -RRB- is involved in neuregulin-1 / ErbB signaling .
20682778	0	neuregulin-1	41,53	ErbB	133,137	neuregulin-1	ErbB	3084	1956	Gene	Gene	integrins|amod|START_ENTITY domain|nmod|integrins binding|nmod|domain involved|nsubjpass|binding involved|nmod|signaling signaling|compound|END_ENTITY	Direct binding of the EGF-like domain of neuregulin-1 to integrins -LRB- -LCB- alpha -RCB- v -LCB- beta -RCB- 3_and _ -LCB- alpha -RCB- 6 -LCB- beta -RCB- 4 -RRB- is involved in neuregulin-1 / ErbB signaling .
16698793	0	neuregulin-1	8,20	ErbB2	21,26	neuregulin-1	ErbB2	112400(Tax:10116)	24337(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|parataxis|signaling signaling|nsubj|END_ENTITY	Role of neuregulin-1 / ErbB2 signaling in endothelium-cardiomyocyte cross-talk .
23466678	0	neuregulin-1	58,70	ErbB2	0,5	neuregulin-1	ErbB2	211323(Tax:10090)	13866(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY dephosphorylation|nmod|cells dephosphorylation|amod|END_ENTITY	ErbB2 dephosphorylation and anti-proliferative effects of neuregulin-1 in ErbB2-overexpressing cells ; re-evaluation of their low-affinity interaction .
9637684	0	neuregulin-1	48,60	ErbB2	4,9	neuregulin-1	ErbB2	211323(Tax:10090)	13866(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	The ErbB2 and ErbB3 receptors and their ligand , neuregulin-1 , are essential for development of the sympathetic nervous system .
24152577	0	neuregulin-1	11,23	NRG-1	25,30	neuregulin-1	NRG-1	112400(Tax:10116)	112400(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Changes of neuregulin-1 -LRB- NRG-1 -RRB- expression in a rat model of overactive_bladder induced by partial urethral_obstruction : is NRG-1 a new biomarker of overactive_bladder ?
18255317	0	neuregulin-1	22,34	NRG1	36,40	neuregulin-1	NRG1	3084	3084	Gene	Gene	variation|amod|START_ENTITY variation|appos|END_ENTITY	Association of 5 ' end neuregulin-1 -LRB- NRG1 -RRB- gene variation with subcortical medial frontal microstructure in humans .
21536100	0	neuregulin-1	54,66	neurotrophic_factor	33,52	neuregulin-1	neurotrophic factor	3084	4908	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	In vitro production of an active neurotrophic_factor , neuregulin-1 : qualitative comparison of different cell-free translation systems .
15494726	0	neuregulin-1_and_Eos	57,77	PSD-95	47,53	neuregulin-1 and Eos	PSD-95	211323;22781	13385(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Activity-dependent transcription regulation of PSD-95 by neuregulin-1_and_Eos .
10369162	0	neuregulin-2	10,22	NRG2	24,28	neuregulin-2	NRG2	9542	9542	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human neuregulin-2 -LRB- NRG2 -RRB- gene : cloning , mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth_disease linked to 5q .
22563075	0	neuregulin_1	99,111	Coronin1B	78,87	neuregulin 1	Coronin1B	3084	57175	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Novel mechanism for negatively regulating Rho-kinase -LRB- ROCK -RRB- signaling through Coronin1B protein in neuregulin_1 -LRB- NRG-1 -RRB- - induced tumor cell motility .
24309211	0	neuregulin_1	78,90	ERBB2	27,32	neuregulin 1	ERBB2	3084	2064	Gene	Gene	signalling|amod|START_ENTITY END_ENTITY|nmod|signalling	Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin_1 type III signalling .
22535374	0	neuregulin_1	99,111	HER3	112,116	neuregulin 1	HER3	3084	2065	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Bone marrow-derived mesenchymal stem cells promote colorectal_cancer_progression through paracrine neuregulin_1 / HER3 signalling .
23328545	0	neuregulin_1	51,63	HER3	64,68	neuregulin 1	HER3	3084	2065	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Spheroid culture of primary lung_cancer cells with neuregulin_1 / HER3 pathway activation .
16687441	0	neuregulin_1	55,67	NRG1	69,73	neuregulin 1	NRG1	3084	3084	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Meta-analysis shows strong positive association of the neuregulin_1 -LRB- NRG1 -RRB- gene with schizophrenia .
12379233	0	neurexin_3	72,82	NRXN3	89,94	neurexin 3	NRXN3	9369	9369	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Identification and characterization of heart-specific splicing of human neurexin_3 mRNA -LRB- NRXN3 -RRB- .
9396755	0	neurexin_IV	50,61	Caspr	28,33	neurexin IV	Caspr	8506	8506	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	The axonal membrane protein Caspr , a homologue of neurexin_IV , is a component of the septate-like paranodal junctions that assemble during myelination .
20410118	0	neurexin_IV	11,22	Roundabout	38,48	neurexin IV	Roundabout	39387(Tax:7227)	37603(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Drosophila neurexin_IV interacts with Roundabout and is required for repulsive midline axon guidance .
25036738	0	neuritin	88,96	MiR-204	0,7	neuritin	MiR-204	83834(Tax:10116)	100314051(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression promotes|advcl|suppressing promotes|nsubj|END_ENTITY	MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression .
15884019	0	neuroblastoma	91,104	heat-shock_protein	58,76	neuroblastoma	heat-shock protein	230972(Tax:10090)	15511(Tax:10090)	Gene	Gene	line|compound|START_ENTITY END_ENTITY|nmod|line	Hypoglycemia enhances the expression of prion_protein and heat-shock_protein 70 in a mouse neuroblastoma cell line .
11267673	0	neurocalcin_delta	61,78	NCALD	85,90	neurocalcin delta	NCALD	83988	83988	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , mapping and characterization of the human neurocalcin_delta gene -LRB- NCALD -RRB- .
9795216	0	neurocan	30,38	CSPG3	45,50	neurocan	CSPG3	1463	1463	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the human neurocan gene , CSPG3 .
19720795	0	neuroendocrine-specific_protein-like_1	19,57	GLUT4	87,92	neuroendocrine-specific protein-like 1	GLUT4	20167(Tax:10090)	20528(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of neuroendocrine-specific_protein-like_1 in membrane translocation of GLUT4 .
22649224	0	neurofascin	43,54	Doublecortin	0,12	neurofascin	Doublecortin	23114	1641	Gene	Gene	endocytosis|nmod|START_ENTITY mediates|dobj|endocytosis mediates|nsubj|END_ENTITY	Doublecortin -LRB- DCX -RRB- mediates endocytosis of neurofascin independently of microtubule binding .
8947556	0	neurofascin	104,115	mucin	117,122	neurofascin	mucin	116690(Tax:10116)	65202(Tax:10116)	Gene	Gene	START_ENTITY|dep|+ +|compound|END_ENTITY	Molecular composition of the node of Ranvier : identification of ankyrin-binding cell adhesion molecules neurofascin -LRB- mucin + / third FNIII domain - -RRB- and NrCAM at nodal axon segments .
11152476	0	neurofascin	37,48	syntenin-1	64,74	neurofascin	syntenin-1	23114	6386	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2 , both of which reveal self-associating activity .
10435592	0	neurofibromatosis	37,54	NF1	56,59	neurofibromatosis	NF1	4763	4763	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Site-specific DNA methylation in the neurofibromatosis -LRB- NF1 -RRB- promoter interferes with binding of CREB and SP1 transcription factors .
2506682	0	neurofibromatosis	33,50	NF1	52,55	neurofibromatosis	NF1	4763	4763	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Progress towards identifying the neurofibromatosis -LRB- NF1 -RRB- gene .
8385067	0	neurofibromatosis	90,107	NF1	109,112	neurofibromatosis	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of sporadic and inherited mutations in exon 31 of the neurofibromatosis -LRB- NF1 -RRB- gene .
8845843	0	neurofibromatosis	50,67	NF1	69,72	neurofibromatosis	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Site and sequence specific DNA methylation in the neurofibromatosis -LRB- NF1 -RRB- gene includes C5839T : the site of the recurrent substitution mutation in exon 31 .
11751683	0	neurofibromatosis_1	23,42	NF1	44,47	neurofibromatosis 1	NF1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Heterozygosity for the neurofibromatosis_1 -LRB- NF1 -RRB- tumor suppressor results in abnormalities in cell attachment , spreading and motility in astrocytes .
12077339	0	neurofibromatosis_1	39,58	NF1	65,68	neurofibromatosis 1	NF1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Astrocyte-specific inactivation of the neurofibromatosis_1 gene -LRB- NF1 -RRB- is insufficient for astrocytoma formation .
7542886	0	neurofibromatosis_1	36,55	NF1	0,3	neurofibromatosis 1	NF1	4763	4763	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	NF1 gene mutations in Japanese with neurofibromatosis_1 -LRB- NF1 -RRB- .
7579150	0	neurofibromatosis_1	18,37	NF1	39,42	neurofibromatosis 1	NF1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the neurofibromatosis_1 -LRB- NF1 -RRB- gene in reactive astrocytes in vitro .
7858173	0	neurofibromatosis_1	40,59	NF1	61,64	neurofibromatosis 1	NF1	4763	4763	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Tissue-specific alternative splicing of neurofibromatosis_1 -LRB- NF1 -RRB- mRNA .
8105688	0	neurofibromatosis_1	30,49	NF1	51,54	neurofibromatosis 1	NF1	4763	4763	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Linkage disequilibrium in the neurofibromatosis_1 -LRB- NF1 -RRB- region : implications for gene mapping .
8182944	0	neurofibromatosis_1	32,51	NF1	53,56	neurofibromatosis 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Absence of rearrangement of the neurofibromatosis_1 -LRB- NF1 -RRB- gene in myelodysplastic_syndromes and acute_myeloid_leukemia .
8730839	0	neurofibromatosis_1	18,37	NF1	39,42	neurofibromatosis 1	NF1	24592(Tax:10116)	24592(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the neurofibromatosis_1 -LRB- NF1 -RRB- gene during growth arrest .
8830850	0	neurofibromatosis_1	73,92	NF1	94,97	neurofibromatosis 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of a developmentally-regulated neuron-specific isoform of the neurofibromatosis_1 -LRB- NF1 -RRB- gene .
10214350	0	neurofibromatosis_2	12,31	Merlin	0,6	neurofibromatosis 2	Merlin	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	suppressor|amod|START_ENTITY END_ENTITY|dep|suppressor	Merlin : the neurofibromatosis_2 tumor suppressor .
14724586	0	neurofibromatosis_2	36,55	NF2	57,60	neurofibromatosis 2	NF2	4771	4771	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Effect of merlin phosphorylation on neurofibromatosis_2 -LRB- NF2 -RRB- gene function .
7795605	0	neurofibromatosis_2	18,37	NF2	39,42	neurofibromatosis 2	NF2	25744(Tax:10116)	25744(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the neurofibromatosis_2 -LRB- NF2 -RRB- gene isoforms during rat embryonic development .
19103750	0	neurofibromatosis_2	4,23	merlin	33,39	neurofibromatosis 2	merlin	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The neurofibromatosis_2 protein , merlin , regulates glial cell growth in an ErbB2 - and Src-dependent manner .
8666669	0	neurofibromatosis_2	130,149	merlin	168,174	neurofibromatosis 2	merlin	4771	32979(Tax:7227)	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis_2 tumor suppressor , merlin .
22807134	0	neurofibromatosis_type-1	136,160	NF1	162,165	neurofibromatosis type-1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein -LRB- GAP -RRB- - related domain of the neurofibromatosis_type-1 -LRB- NF1 -RRB- gene .
17241271	0	neurofibromatosis_type_1	40,64	ERK	95,98	neurofibromatosis type 1	ERK	18015(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Restored plasticity in a mouse model of neurofibromatosis_type_1 via inhibition of hyperactive ERK and CREB .
10360836	0	neurofibromatosis_type_1	40,64	NF1	66,69	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	EVI2B , a gene lying in an intron of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene , is as the NF1 gene involved in differentiation of melanocytes and keratinocytes and is overexpressed in cells derived from NF1 neurofibromas .
10674164	0	neurofibromatosis_type_1	76,100	NF1	102,105	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel and very peculiar HincII polymorphism in the 5 ' region of the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
10684924	0	neurofibromatosis_type_1	58,82	NF1	84,87	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Cold_shock induces the insertion of a cryptic exon in the neurofibromatosis_type_1 -LRB- NF1 -RRB- mRNA .
10782929	0	neurofibromatosis_type_1	52,76	NF1	78,81	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the 5 ' - flanking region of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene : identification of five sequence variants .
10878667	0	neurofibromatosis_type_1	65,89	NF1	91,94	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Segmental_neurofibromatosis is caused by somatic mutation of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
11129335	0	neurofibromatosis_type_1	20,44	NF1	46,49	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic loss at the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene locus is frequent in desmoplastic_neurotropic_melanoma .
11292340	0	neurofibromatosis_type_1	24,48	NF1	50,53	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene promotes skipping of two exons by preventing exon definition .
11735023	0	neurofibromatosis_type_1	107,131	NF1	134,137	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of denaturing high performance liquid chromatography -LRB- DHPLC -RRB- for the mutational analysis of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
11748857	0	neurofibromatosis_type_1	79,103	NF1	105,108	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of four novel large deletions in the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
12112660	0	neurofibromatosis_type_1	33,57	NF1	59,62	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ten novel mutations in the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in Italian patients .
1293177	0	neurofibromatosis_type_1	4,28	NF1	30,33	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The neurofibromatosis_type_1 -LRB- NF1 -RRB- gene : identification and partial characterization of a putative tumor suppressor gene .
14564162	0	neurofibromatosis_type_1	43,67	NF1	69,72	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A large deletion -LRB- 1.5 Mb -RRB- encompassing the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in a patient with sporadic NF1 associated with dysmorphism , mental_retardation , and unusual ocular and skeletal features .
14722917	0	neurofibromatosis_type_1	59,83	NF1	85,88	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the somatic mutational spectrum of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in neurofibromatosis patients with benign and malignant_tumors .
15523626	0	neurofibromatosis_type_1	99,123	NF1	125,128	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional analysis of polymorphic variation within the promoter and 5 ' untranslated region of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
16117786	0	neurofibromatosis_type_1	82,106	NF1	60,63	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Gonosomal mosaicism for a nonsense mutation -LRB- R1947X -RRB- in the NF1 gene in segmental neurofibromatosis_type_1 .
24676943	0	neurofibromatosis_type_1	116,140	NF1	142,145	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fast and robust next-generation sequencing technique using ion torrent personal genome machine for the screening of neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
26633276	0	neurofibromatosis_type_1	83,107	NF1	109,112	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Molecular diagnosis as a strategy for differential diagnosis and at early ages of neurofibromatosis_type_1 -LRB- NF1 -RRB- -RSB- .
7568895	0	neurofibromatosis_type_1	18,42	NF1	44,47	neurofibromatosis type 1	NF1	18015(Tax:10090)	18015(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene during mouse embryonic development .
7607647	0	neurofibromatosis_type_1	36,60	NF1	62,65	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A Tsp509I variant in exon 13 of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene allows the identification of both alleles at the mRNA level .
7657385	0	neurofibromatosis_type_1	42,66	NF1	68,71	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the GAP-related domain of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in childhood brain_tumors .
8034304	0	neurofibromatosis_type_1	35,59	NF1	61,64	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A deletion in the 5 ' - region of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8207976	0	neurofibromatosis_type_1	66,90	NF1	92,95	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of mutations and expression of GAP-related domain of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene in the progression of chronic_myelogenous_leukemia .
8225323	0	neurofibromatosis_type_1	46,70	NF1	72,75	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A de novo nonsense mutation in exon 28 of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8225327	0	neurofibromatosis_type_1	73,97	NF1	99,102	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A highly informative CA/GT repeat polymorphism in intron 38 of the human neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8320697	0	neurofibromatosis_type_1	19,43	NF1	45,48	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A genetic study of neurofibromatosis_type_1 -LRB- NF1 -RRB- in south-western Ontario .
8353492	0	neurofibromatosis_type_1	70,94	NF1	96,99	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel alleles , hemizygosity and deletions at an Alu-repeat within the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8364582	0	neurofibromatosis_type_1	61,85	NF1	87,90	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An alternatively-spliced mRNA in the carboxy terminus of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene is expressed in muscle .
8504305	0	neurofibromatosis_type_1	35,59	NF1	61,64	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Evidence of DNA methylation in the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene region of 17q11 .2 .
8530015	0	neurofibromatosis_type_1	102,126	NF1	128,131	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single-cell PCR performed with neurofibroma Schwann cells reveals the presence of both alleles of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
8544190	0	neurofibromatosis_type_1	46,70	NF1	72,75	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterisation of germline mutations in the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
9003501	0	neurofibromatosis_type_1	42,66	NF1	68,71	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational and functional analysis of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
9150739	0	neurofibromatosis_type_1	76,100	NF1	102,105	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization and significance of nine novel mutations in exon 16 of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene .
9654211	0	neurofibromatosis_type_1	23,47	NF1	49,52	neurofibromatosis type 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gross deletions of the neurofibromatosis_type_1 -LRB- NF1 -RRB- gene are predominantly of maternal origin and commonly associated with a learning_disability , dysmorphic_features and developmental_delay .
15767669	0	neurofibromatosis_type_1	118,142	TLF/TRF2	162,170	neurofibromatosis type 1	TLF/TRF2	18015(Tax:10090)	109824;237336	Gene	Gene	genes|amod|START_ENTITY genes|nmod|END_ENTITY	TATA-binding_protein _ -LRB- TBP -RRB- - like_factor -LRB- TLF -RRB- is a functional regulator of transcription : reciprocal regulation of the neurofibromatosis_type_1 and c-fos genes by TLF/TRF2 and TBP .
25549701	0	neurofibromatosis_type_2	66,90	MN1	115,118	neurofibromatosis type 2	MN1	4771	4330	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Exome sequencing on malignant_meningiomas identified mutations in neurofibromatosis_type_2 -LRB- NF2 -RRB- and meningioma_1 -LRB- MN1 -RRB- genes .
15681480	0	neurofibromatosis_type_2	61,85	NF2	87,90	neurofibromatosis type 2	NF2	4771	4771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sensitive detection of deletions of one or more exons in the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene by multiplexed gene dosage polymerase chain reaction .
20831745	0	neurofibromatosis_type_2	35,59	NF2	61,64	neurofibromatosis type 2	NF2	4771	4771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	CpG island hypermethylation of the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene is rare in sporadic vestibular_schwannomas .
7981675	0	neurofibromatosis_type_2	37,61	NF2	63,66	neurofibromatosis type 2	NF2	18016(Tax:10090)	18016(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Alternative transcripts in the mouse neurofibromatosis_type_2 -LRB- NF2 -RRB- gene are conserved and code for schwannomins with distinct C-terminal domains .
8655144	0	neurofibromatosis_type_2	31,55	NF2	57,60	neurofibromatosis type 2	NF2	4771	4771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Screening for mutations in the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene in sporadic_meningiomas .
8755919	0	neurofibromatosis_type_2	24,48	NF2	55,58	neurofibromatosis type 2	NF2	4771	4771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Type of mutation in the neurofibromatosis_type_2 gene -LRB- NF2 -RRB- frequently determines severity of disease .
9225971	0	neurofibromatosis_type_2	50,74	NF2	76,79	neurofibromatosis type 2	NF2	4771	4771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis and expression studies of the neurofibromatosis_type_2 -LRB- NF2 -RRB- gene in a patient with a ring_chromosome_22_and_NF2 .
23506114	0	neurofibromin	20,33	Nf1	40,43	neurofibromin	Nf1	43149(Tax:7227)	43149(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the neurofibromin gene , Nf1 , is associated with antagonistic selection on wing size and development time in Drosophila_melanogaster .
23242790	0	neurofibromin	12,25	dopamine_D3_receptor	70,90	neurofibromin	dopamine D3 receptor	18015(Tax:10090)	13490(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Hippocampal neurofibromin and amyloid_precursor_protein expression in dopamine_D3_receptor knock-out mice following passive avoidance conditioning .
22851646	0	neurofibromin_1	40,55	NF1	62,65	neurofibromin 1	NF1	4763	4763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparative oncogenomics implicates the neurofibromin_1 gene -LRB- NF1 -RRB- as a breast_cancer driver .
15371411	0	neurofibromin_1	95,110	interferon_consensus_sequence-binding_protein	4,49	neurofibromin 1	interferon consensus sequence-binding protein	18015(Tax:10090)	15900(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	The interferon_consensus_sequence-binding_protein activates transcription of the gene encoding neurofibromin_1 .
15028764	0	neurofilament	34,47	NF-L	49,53	neurofilament	NF-L	18039(Tax:10090)	18039(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	3 ' untranslated region in a light neurofilament -LRB- NF-L -RRB- mRNA triggers aggregation of NF-L and mutant superoxide_dismutase_1 proteins in neuronal cells .
7477677	0	neurofilament	35,48	NF-L	50,54	neurofilament	NF-L	18039(Tax:10090)	18039(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of low-molecular-weight neurofilament -LRB- NF-L -RRB- mRNA during postnatal development of the mouse brain .
9189892	0	neurofilament	41,54	NF-L	56,60	neurofilament	NF-L	4747	4747	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Marked decrease of immunolabelled 68 kDa neurofilament -LRB- NF-L -RRB- proteins in brains of opiate addicts .
17120287	0	neurofilament	70,83	NF-M	85,89	neurofilament	NF-M	751981(Tax:59729)	751981(Tax:59729)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Enriched expression and developmental regulation of the middle-weight neurofilament -LRB- NF-M -RRB- gene in song control nuclei of the zebra_finch .
11483667	0	neurofilament_light	45,64	Interleukin-1beta	0,17	neurofilament light	Interleukin-1beta	4747	3553	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Interleukin-1beta up-regulates expression of neurofilament_light in human neuronal cells .
14733962	0	neurofilament_light	10,29	NEFL	31,35	neurofilament light	NEFL	4747	4747	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	The novel neurofilament_light -LRB- NEFL -RRB- mutation Glu397Lys is associated with a clinically and morphologically heterogeneous type of Charcot-Marie-Tooth_neuropathy .
15742362	0	neurofilament_of_low-molecular-weight	22,59	Nefl	61,65	neurofilament of low-molecular-weight	Nefl	18039(Tax:10090)	18039(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mice with the deleted neurofilament_of_low-molecular-weight -LRB- Nefl -RRB- gene : 1 .
11034913	0	neurofilament_protein-H	30,53	NF-H	55,59	neurofilament protein-H	NF-H	4744	4744	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The C-terminal tail domain of neurofilament_protein-H -LRB- NF-H -RRB- forms the crossbridges and regulates neurofilament bundle formation .
12889063	0	neurogenin-1	13,25	sonic_hedgehog	40,54	neurogenin-1	sonic hedgehog	4762	6469	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of neurogenin-1 expression by sonic_hedgehog : Its role in development of trigeminal sensory neurons .
21818269	0	neurogenin3	72,83	Formin1	0,7	neurogenin3	Formin1	11925(Tax:10090)	14260(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons .
19813087	0	neurogenin_1	21,33	LGR5	42,46	neurogenin 1	LGR5	4762	8549	Gene	Gene	expression|nmod|START_ENTITY induces|nsubj|expression induces|dobj|END_ENTITY	Stable expression of neurogenin_1 induces LGR5 , a novel stem cell marker , in an immortalized human neural stem cell line HB1.F3 .
22674256	0	neurogenin_2	26,38	GSK3	0,4	neurogenin 2	GSK3	11924(Tax:10090)	56637(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	GSK3 temporally regulates neurogenin_2 proneural activity in the neocortex .
10757813	0	neurogenin_3	67,79	BETA2	49,54	neurogenin 3	BETA2	11925(Tax:10090)	18012(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the pancreatic islet-specific gene BETA2 -LRB- neuroD -RRB- by neurogenin_3 .
21786021	0	neurogenin_3	59,71	GLIS3	38,43	neurogenin 3	GLIS3	11925(Tax:10090)	226075(Tax:10090)	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	The Kr ppel-like zinc finger protein GLIS3 transactivates neurogenin_3 for proper fetal pancreatic islet differentiation in mice .
22820919	0	neurogenin_3	16,28	Glis3	0,5	neurogenin 3	Glis3	50674	169792	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glis3 regulates neurogenin_3 expression in pancreatic b-cells and interacts with its activator , Hnf6 .
11246894	0	neurogenin_3	38,50	NEUROG3	57,64	neurogenin 3	NEUROG3	50674	50674	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the coding region of the neurogenin_3 gene -LRB- NEUROG3 -RRB- are not a common cause of maturity-onset_diabetes_of_the_young in Japanese subjects .
21074524	0	neurogenin_3	30,42	POMC	65,69	neurogenin 3	POMC	11925(Tax:10090)	18976(Tax:10090)	Gene	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Differential requirements for neurogenin_3 in the development of POMC and NPY neurons in the hypothalamus .
25652387	0	neurogenin_3	21,33	SOX4	0,4	neurogenin 3	SOX4	11925(Tax:10090)	20677(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	SOX4 cooperates with neurogenin_3 to regulate endocrine pancreas formation in mouse models .
15122877	0	neuroglobin	21,32	cystatin_C	38,48	neuroglobin	cystatin C	58157	1471	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human neuroglobin with cystatin_C , a cysteine_proteinase_inhibitor .
15120622	0	neuroglobin	6,17	flotillin-1	33,44	neuroglobin	flotillin-1	58157	10211	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human neuroglobin interacts with flotillin-1 , a lipid raft microdomain-associated protein .
11820779	0	neuroglobin	34,45	neuroglobin	75,86	neuroglobin	neuroglobin	58157	85382(Tax:10116)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin .
11820779	0	neuroglobin	75,86	neuroglobin	34,45	neuroglobin	neuroglobin	85382(Tax:10116)	58157	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin .
23481873	0	neuroglobin	36,47	neuroglobin	59,70	neuroglobin	neuroglobin	100000711(Tax:7955)	100000711(Tax:7955)	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Functional characterization of fish neuroglobin : zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve_injury and can translocate into ZF4 cells .
23481873	0	neuroglobin	59,70	neuroglobin	36,47	neuroglobin	neuroglobin	100000711(Tax:7955)	100000711(Tax:7955)	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of fish neuroglobin : zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve_injury and can translocate into ZF4 cells .
19050768	0	neuroglycan_C	13,26	Rpe65	69,74	neuroglycan C	Rpe65	29873(Tax:10090)	19892(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Differential neuroglycan_C expression during retinal_degeneration in Rpe65 - / - mice .
10618501	0	neurogranin	93,104	NRGN	106,110	neurogranin	NRGN	4900	4900	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a cis-acting element that interferes with thyroid hormone induction of the neurogranin -LRB- NRGN -RRB- gene .
21538840	0	neurogranin	12,23	NRGN	25,29	neurogranin	NRGN	4900	4900	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of neurogranin -LRB- NRGN -RRB- in schizophrenia .
9143500	0	neurogranin	62,73	NRGN	80,84	neurogranin	NRGN	4900	4900	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure , organization , and chromosomal mapping of the human neurogranin gene -LRB- NRGN -RRB- .
7730337	0	neurogranin	93,104	RC3	106,109	neurogranin	RC3	64356(Tax:10116)	64356(Tax:10116)	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Structure and regulation of the gene encoding the neuron-specific protein_kinase_C substrate neurogranin -LRB- RC3 protein -RRB- .
7898318	0	neurogranin	21,32	RC3	16,19	neurogranin	RC3	64356(Tax:10116)	64356(Tax:10116)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of RC3 -LRB- neurogranin -RRB- in rat brain subcellular fractions .
8080473	0	neurogranin	71,82	RC3	58,61	neurogranin	RC3	64356(Tax:10116)	64356(Tax:10116)	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Characterization of a 7.5-kDa protein_kinase_C substrate -LRB- RC3 protein , neurogranin -RRB- from rat brain .
19751214	0	neurogranin	36,47	neuronal_nuclei	51,66	neurogranin	neuronal nuclei	64356(Tax:10116)	287847(Tax:10116)	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Activity-dependent translocation of neurogranin to neuronal_nuclei .
16413782	0	neurokinin	61,71	NK1	73,76	neurokinin	NK1	6869	6869	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	1-Phenyl-8-azabicyclo -LSB- 3.2.1 -RSB- octane_ethers : a novel series of neurokinin -LRB- NK1 -RRB- antagonists .
16155744	0	neurokinin-1	36,48	NK1	50,53	neurokinin-1	NK1	6869	6869	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Visualization and quantification of neurokinin-1 -LRB- NK1 -RRB- receptors in the human brain .
18042005	0	neurokinin-1	27,39	receptor	40,48	neurokinin-1	receptor	6863	6869	Gene	Gene	antagonist|amod|START_ENTITY antagonist|compound|END_ENTITY	Fosaprepitant -LRB- MK-0517 -RRB- : a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea_and_vomiting .
1379628	0	neurokinin-1	57,69	substance_P	45,56	neurokinin-1	substance P	6863	6863	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Modulatory role of glutathione on mu-opioid , substance_P / neurokinin-1 , and kainic_acid receptor binding sites .
17370082	0	neurokinin-1	38,50	substance_P	9,20	neurokinin-1	substance P	6863	6863	Gene	Gene	START_ENTITY|nsubj|Study Study|nmod|END_ENTITY	Study of substance_P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus .
10564361	0	neurokinin-1	40,52	substance_P_receptor	18,38	neurokinin-1	substance P receptor	21333(Tax:10090)	21336(Tax:10090)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Disruption of the substance_P_receptor -LRB- neurokinin-1 -RRB- gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation .
10228123	0	neurokinin-1_receptor	30,51	Nerve_growth_factor	0,19	neurokinin-1 receptor	Nerve growth factor	100135626(Tax:10141)	4803	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Nerve_growth_factor induces a neurokinin-1_receptor - mediated airway hyperresponsiveness in guinea_pigs .
9121675	0	neurokinin-1_receptor	18,39	c-fos	60,65	neurokinin-1 receptor	c-fos	24807(Tax:10116)	314322(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	A contribution of neurokinin-1_receptor to formalin-induced c-fos expression in the rat spinal dorsal horn .
23979140	0	neurokinin-1_receptor	58,79	norepinephrine_transporter	10,36	neurokinin-1 receptor	norepinephrine transporter	6869	6530	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Regulated norepinephrine_transporter interaction with the neurokinin-1_receptor establishes transporter subcellular localization .
15023054	0	neurokinin-2	60,72	NK2	74,77	neurokinin-2	NK2	6863	6863	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Evidence for the proximity of the extreme N-terminus of the neurokinin-2 -LRB- NK2 -RRB- tachykinin receptor to Cys167 in the putative fourth transmembrane helix .
7499223	0	neurokinin-2	25,37	NK2	39,42	neurokinin-2	NK2	735077(Tax:8355)	735077(Tax:8355)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	A single mutation of the neurokinin-2 -LRB- NK2 -RRB- _ receptor prevents agonist-induced desensitization .
11350816	0	neurokinin-2	56,68	neurokinin_A	28,40	neurokinin-2	neurokinin A	6863	6863	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Developmental expression of neurokinin_A and functional neurokinin-2 receptors in lung .
1333574	0	neurokinin-A	64,76	NK-2	88,92	neurokinin-A	NK-2	6863	6863	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Pharmacologic characterization of the novel ligand -LSB- 4,5-3H-Leu9 -RSB- neurokinin-A binding to NK-2 receptors on hamster_urinary_bladder_membranes .
16388914	0	neurokinin_1	27,39	NK1	51,54	neurokinin 1	NK1	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression of substance_P , neurokinin_1 receptors -LRB- NK1 -RRB- and neurokinin_3_receptors in the developing mouse retina and in the retina of NK1 knockout mice .
11588191	0	neurokinin_1	75,87	substance_P	62,73	neurokinin 1	substance P	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	changes|appos|START_ENTITY changes|nmod|END_ENTITY	5-hydroxytryptamine -LRB- 5-HT -RRB- 1A autoreceptor adaptive changes in substance_P -LRB- neurokinin_1 -RRB- receptor knock-out mice mimic antidepressant-induced desensitization .
15030389	0	neurokinin_1	25,37	substance_P	12,23	neurokinin 1	substance P	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Blockade of substance_P -LRB- neurokinin_1 -RRB- receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor : an in vivo microdialysis study in mice .
21878523	0	neurokinin_1_receptor	75,96	Endothelin-converting_enzyme-1	0,30	neurokinin 1 receptor	Endothelin-converting enzyme-1	24807(Tax:10116)	94204(Tax:10116)	Gene	Gene	trafficking|nmod|START_ENTITY regulates|dobj|trafficking regulates|nsubj|END_ENTITY	Endothelin-converting_enzyme-1 regulates trafficking and signalling of the neurokinin_1_receptor in endosomes of myenteric neurones .
14525527	0	neurokinin_1_receptor	45,66	NK1-R	68,73	neurokinin 1 receptor	NK1-R	24807(Tax:10116)	24807(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pregnancy-induced changes in substance P and neurokinin_1_receptor -LRB- NK1-R -RRB- expression in the rat uterus .
15334646	0	neurokinin_1_receptor	16,37	NK1R	39,43	neurokinin 1 receptor	NK1R	24807(Tax:10116)	24807(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Localization of neurokinin_1_receptor -LRB- NK1R -RRB- immunoreactivity in rat esophagus .
9371207	0	neurokinin_A	11,23	NKA	25,28	neurokinin A	NKA	6863	6863	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in neurokinin_A -LRB- NKA -RRB- airway responsiveness with inhaled frusemide in asthma .
22189180	0	neurokinin_A	55,67	P_protein	87,96	neurokinin A	P protein	6863	4948	Gene	Gene	antibodies|compound|START_ENTITY antibodies|compound|END_ENTITY	The possible link between the elevated serum levels of neurokinin_A and anti-ribosomal P_protein antibodies in children with autism .
11350816	0	neurokinin_A	28,40	neurokinin-2	56,68	neurokinin A	neurokinin-2	6863	6863	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Developmental expression of neurokinin_A and functional neurokinin-2 receptors in lung .
1311427	0	neurokinin_A	72,84	neuropeptide_K	29,43	neurokinin A	neuropeptide K	6863	6863	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the effects of neuropeptide_K and neuropeptide_gamma with neurokinin_A at NK2_receptors in the hamster urinary bladder .
7681831	0	neurokinin_B	32,44	NK3	27,30	neurokinin B	NK3	6866	4824	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Chimeric NK1 -LRB- substance_P -RRB- / NK3 -LRB- neurokinin_B -RRB- receptors .
23656837	0	neurokinin_B	39,51	NK3_receptor	58,70	neurokinin B	NK3 receptor	6866	6870	Gene	Gene	expression|nmod|START_ENTITY expression|dep|system system|amod|END_ENTITY	Differentially regulated expression of neurokinin_B -LRB- NKB -RRB- / NK3_receptor system in uterine leiomyomata .
16518717	0	neurokinin_B	33,45	NKB	47,50	neurokinin B	NKB	29191(Tax:10116)	29191(Tax:10116)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Membrane associated functions of neurokinin_B -LRB- NKB -RRB- on Abeta -LRB- 25-35 -RRB- induced toxicity in aging rat brain synaptosomes .
10770936	0	neuroleukin	76,87	phosphoglucose_isomerase	25,49	neuroleukin	phosphoglucose isomerase	14751(Tax:10090)	14751(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The crystal structure of phosphoglucose_isomerase / autocrine_motility_factor / neuroleukin complexed with its carbohydrate_phosphate inhibitors suggests its substrate/receptor recognition .
3191476	0	neuroleukin	133,144	phosphohexose_isomerase	37,60	neuroleukin	phosphohexose isomerase	2821	2821	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and characterization of phosphohexose_isomerase from human gastrointestinal_carcinoma and its potential relationship to neuroleukin .
24336150	0	neuroligin-1	26,38	CaMKII	0,6	neuroligin-1	CaMKII	22871	818	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses .
21551456	0	neuroligin-2	72,84	NLGN2	91,96	neuroligin-2	NLGN2	57555	57555	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and functional characterization of rare mutations of the neuroligin-2 gene -LRB- NLGN2 -RRB- associated with schizophrenia .
19915562	0	neuroligin_1	75,87	Thrombospondin_1	0,16	neuroligin 1	Thrombospondin 1	116647(Tax:10116)	445442(Tax:10116)	Gene	Gene	accelerates|nmod|START_ENTITY accelerates|nsubj|END_ENTITY	Thrombospondin_1 accelerates synaptogenesis in hippocampal neurons through neuroligin_1 .
16750657	0	neurolin-like_cell_adhesion_molecule	35,71	NLCAM	73,78	neurolin-like cell adhesion molecule	NLCAM	323919(Tax:7955)	323919(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Comparison of neurolin -LRB- ALCAM -RRB- and neurolin-like_cell_adhesion_molecule -LRB- NLCAM -RRB- expression in zebrafish .
8163469	0	neuromedin_B	19,31	NMB-R	43,48	neuromedin B	NMB-R	25264(Tax:10116)	25264(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Desensitization of neuromedin_B receptors -LRB- NMB-R -RRB- on native and NMB-R-transfected cells involves down-regulation and internalization .
12231437	0	neuromedin_B_receptor	71,92	NMB-R	94,99	neuromedin B receptor	NMB-R	18101(Tax:10090)	18101(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Restraint stress impaired maternal behavior in female mice lacking the neuromedin_B_receptor -LRB- NMB-R -RRB- gene .
10783389	0	neuromedin_U	18,30	FM-3	94,98	neuromedin U	FM-3	10874	10316	Gene	Gene	Identification|nmod|START_ENTITY ligand|nsubj|Identification ligand|nmod|END_ENTITY	Identification of neuromedin_U as the cognate ligand of the orphan G protein-coupled receptor FM-3 .
16466693	0	neuromedin_U	17,29	IL-6	39,43	neuromedin U	IL-6	56183(Tax:10090)	16193(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|production production|compound|END_ENTITY	The neuropeptide neuromedin_U promotes IL-6 production from macrophages and endotoxin shock .
20969804	0	neuron-derived_neurotrophic_factor	38,72	NDNF	74,78	neuron-derived neurotrophic factor	NDNF	68169(Tax:10090)	68169(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Spatio-temporal expression of a novel neuron-derived_neurotrophic_factor -LRB- NDNF -RRB- in mouse brains during development .
9573341	0	neuron-derived_orphan_receptor-1	49,81	NOR-1	83,88	neuron-derived orphan receptor-1	NOR-1	8013	8013	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Alternative splicing generates isoforms of human neuron-derived_orphan_receptor-1 -LRB- NOR-1 -RRB- mRNA .
3511068	0	neuron-glia_cell_adhesion_molecule	43,77	Nerve_growth_factor	0,19	neuron-glia cell adhesion molecule	Nerve growth factor	50687(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Nerve_growth_factor enhances expression of neuron-glia_cell_adhesion_molecule in PC12 cells .
18657578	0	neuron-restrictive_silencer_factor	18,52	NRSF	54,58	neuron-restrictive silencer factor	NRSF	83618(Tax:10116)	83618(Tax:10116)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Novel function of neuron-restrictive_silencer_factor -LRB- NRSF -RRB- for posttranscriptional regulation .
9856348	0	neuron-restrictive_silencer_factor	27,61	NRSF	63,67	neuron-restrictive silencer factor	NRSF	19712(Tax:10090)	19712(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	No effect of expression of neuron-restrictive_silencer_factor -LRB- NRSF -RRB- protein on N-type Ca2 + channel alpha 1B gene promoter activity in NS20Y cells .
16764822	0	neuron-restrictive_silencer_factor	49,83	tyrosine_hydroxylase	20,40	neuron-restrictive silencer factor	tyrosine hydroxylase	5978	7054	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of human tyrosine_hydroxylase gene by neuron-restrictive_silencer_factor .
3026253	0	neuron-specific_enolase	7,30	CEA	120,123	neuron-specific enolase	CEA	2026	1084	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|-RSB- -RSB-|appos|END_ENTITY	-LSB- Serum neuron-specific_enolase -LRB- NSE -RRB- in patients with small cell lung_cancer -- comparison with carcinoembryonic_antigen -LRB- CEA -RRB- -RSB- .
9595992	0	neuron-specific_enolase	43,66	CSF	29,32	neuron-specific enolase	CSF	2026	1437	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Status_epilepticus increases CSF levels of neuron-specific_enolase and alters the blood-brain barrier .
10569138	0	neuron-specific_enolase	76,99	Chromogranin-A	0,14	neuron-specific enolase	Chromogranin-A	2026	1113	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Chromogranin-A as a serum marker for neuroendocrine_tumors : comparison with neuron-specific_enolase and correlation with immunohistochemical findings .
9253344	0	neuron-specific_enolase	77,100	Chromogranin_A	0,14	neuron-specific enolase	Chromogranin A	2026	1113	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Chromogranin_A as serum marker for neuroendocrine neoplasia : comparison with neuron-specific_enolase and the alpha-subunit of glycoprotein hormones .
21995595	0	neuron-specific_enolase	79,102	ENO2	109,113	neuron-specific enolase	ENO2	2026	2026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparative gene expression profiling analysis of lymphoblastoid cells reveals neuron-specific_enolase gene -LRB- ENO2 -RRB- as a susceptibility gene of heroin_dependence .
11985791	0	neuron-specific_enolase	23,46	NSE	48,51	neuron-specific enolase	NSE	2026	2026	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of neuron-specific_enolase -LRB- NSE -RRB- in pyothorax-associated_lymphoma -LRB- PAL -RRB- .
12297981	0	neuron-specific_enolase	57,80	NSE	82,85	neuron-specific enolase	NSE	2026	2026	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Hemangiosarcoma_of_the_liver with unusual expression of neuron-specific_enolase -LRB- NSE -RRB- -RSB- .
18383893	0	neuron-specific_enolase	42,65	NSE	67,70	neuron-specific enolase	NSE	2026	2026	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Predictive and prognostic significance of neuron-specific_enolase -LRB- NSE -RRB- in non-small_cell_lung_cancer .
2092546	1	neuron-specific_enolase	186,209	NSE	211,214	neuron-specific enolase	NSE	2026	2026	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Review of the literature and own experience with serum analysis of sialic_acid -LRB- NANA -RRB- , carcinoembryonic_antigen -LRB- CEA -RRB- and neuron-specific_enolase -LRB- NSE -RRB- -RSB- .
21165441	0	neuron-specific_enolase	20,43	NSE	45,48	neuron-specific enolase	NSE	2026	2026	Gene	Gene	Immunoreactivity|nmod|START_ENTITY Immunoreactivity|appos|END_ENTITY	Immunoreactivity of neuron-specific_enolase -LRB- NSE -RRB- in human pancreas in health and type_1_diabetes_mellitus .
24746933	0	neuron-specific_enolase	39,62	NSE	64,67	neuron-specific enolase	NSE	2026	2026	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated levels of cerebrospinal fluid neuron-specific_enolase -LRB- NSE -RRB- in Alzheimer 's _ disease .
3039919	0	neuron-specific_enolase	12,35	NSE	7,10	neuron-specific enolase	NSE	2026	2026	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	-LSB- Serum NSE -LRB- neuron-specific_enolase -RRB- levels in small cell lung_cancer , with special reference to the measurement of serial serum NSE levels -RSB- .
3524110	1	neuron-specific_enolase	119,142	NSE	144,147	neuron-specific enolase	NSE	2026	2026	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	A comparative study with special emphasis on S-100 protein , serotonin and neuron-specific_enolase -LRB- NSE -RRB- immunoreactivity .
3587757	0	neuron-specific_enolase	16,39	NSE	41,44	neuron-specific enolase	NSE	2026	2026	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of neuron-specific_enolase -LRB- NSE -RRB- mRNA in human brain .
7825447	0	neuron-specific_enolase	20,43	NSE	45,48	neuron-specific enolase	NSE	2026	2026	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The fluctuations of neuron-specific_enolase -LRB- NSE -RRB- levels of cerebrospinal fluid during bacterial_meningitis : the relationship between the fluctuations of NSE levels and neurological complications or outcome .
9061616	0	neuron-specific_enolase	56,79	NSE	81,84	neuron-specific enolase	NSE	24334(Tax:10116)	24334(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequences in the proximal 5 ' flanking region of the rat neuron-specific_enolase -LRB- NSE -RRB- gene are sufficient for cell type-specific reporter gene expression .
19535196	0	neuron-specific_enolase	28,51	S-100B	6,12	neuron-specific enolase	S-100B	2026	6285	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|END_ENTITY	Serum S-100B is superior to neuron-specific_enolase as an early prognostic biomarker for neurological outcome following cardiopulmonary resuscitation .
1424333	0	neuron-specific_enolase	83,106	S-100b	108,114	neuron-specific enolase	S-100b	2026	6285	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	-LSB- Central_nervous_system_disorders in myotonic_dystrophy -- with special reference to neuron-specific_enolase , S-100b protein and creatine_kinase_BB isoenzyme levels in CSF -RSB- .
21251388	0	neuron-specific_enolase	64,87	S-100b	89,95	neuron-specific enolase	S-100b	2026	6285	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	-LSB- Effects of recombinant human erythropoietin on serum levels of neuron-specific_enolase , S-100b protein and myelin_basic_protein in rats following status_epilepticus -RSB- .
2791404	0	neuron-specific_enolase	106,129	S-100b	131,137	neuron-specific enolase	S-100b	2026	6285	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	-LSB- Cerebrospinal fluid level of aldolase_C in patients with various neurological_disorders : comparison with neuron-specific_enolase , S-100b protein and creatine_kinase_BB_isoenzyme -RSB- .
23473361	0	neuron-specific_enolase	50,73	S100b	14,19	neuron-specific enolase	S100b	2026	6285	Gene	Gene	impact|nmod|START_ENTITY impact|nmod|END_ENTITY	The impact of S100b and persistent high levels of neuron-specific_enolase on cognitive performance in elderly patients after cardiopulmonary bypass .
11288956	0	neuron-specific_enolase	114,137	chromogranin_A	27,41	neuron-specific enolase	chromogranin A	2026	1113	Gene	Gene	evaluation|nmod|START_ENTITY assay|dep|evaluation assay|nmod|END_ENTITY	Immunoradiometric assay of chromogranin_A in the diagnosis of small_cell_lung_cancer : comparative evaluation with neuron-specific_enolase .
17585539	0	neuron-specific_enolase	34,57	chromogranin_A	18,32	neuron-specific enolase	chromogranin A	2026	1113	Gene	Gene	product|dep|START_ENTITY product|compound|END_ENTITY	Selected markers -LRB- chromogranin_A , neuron-specific_enolase , synaptophysin , protein gene product 9.5 -RRB- in diagnosis and prognosis of neuroendocrine_pulmonary_tumours .
1629611	0	neuron-specific_gamma_isozyme_of_human_enolase	59,105	NSE	107,110	neuron-specific gamma isozyme of human enolase	NSE	2026	2026	Gene	Gene	assay|nmod|START_ENTITY assay|appos|END_ENTITY	A simple enzyme-linked immunosorbent assay -LRB- ELISA -RRB- for the neuron-specific_gamma_isozyme_of_human_enolase -LRB- NSE -RRB- using monoclonal antibodies raised against synthetic peptides corresponding to isozyme sequence differences .
1324376	0	neuron_specific_enolase	7,30	NSE	32,35	neuron specific enolase	NSE	2026	2026	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	-LSB- Serum neuron_specific_enolase -LRB- NSE -RRB- levels in patients with non_small_cell_lung_cancer -RSB- .
6852200	0	neuron_specific_enolase	27,50	NSE	52,55	neuron specific enolase	NSE	2026	2026	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Intramural distribution of neuron_specific_enolase -LRB- NSE -RRB- in the human gastrointestinal tract .
23020797	0	neuronal_PAS_domain_4	35,56	Npas4	58,63	neuronal PAS domain 4	Npas4	225872(Tax:10090)	225872(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional suppression of the neuronal_PAS_domain_4 -LRB- Npas4 -RRB- gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter .
15635607	0	neuronal_PAS_domain_protein_1	18,47	erythropoietin	51,65	neuronal PAS domain protein 1	erythropoietin	4861	2056	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Novel function of neuronal_PAS_domain_protein_1 in erythropoietin expression in neuronal cells .
11930148	0	neuronal_apoptosis_inhibitory_protein	23,60	NAIP	62,66	neuronal apoptosis inhibitory protein	NAIP	17940(Tax:10090)	17940(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Distinct expression of neuronal_apoptosis_inhibitory_protein -LRB- NAIP -RRB- during murine development .
12496348	0	neuronal_calcium_sensor-1	17,42	NCS-1	44,49	neuronal calcium sensor-1	NCS-1	23413	23413	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of neuronal_calcium_sensor-1 -LRB- NCS-1 -RRB- in the prefrontal cortex of schizophrenic and bipolar patients .
14760944	0	neuronal_calcium_sensor-1	47,72	NCS-1	74,79	neuronal calcium sensor-1	NCS-1	23413	23413	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Identification and subcellular localization of neuronal_calcium_sensor-1 -LRB- NCS-1 -RRB- in human neutrophils and HL-60 cells .
20483466	0	neuronal_cell_adhesion_molecule	13,44	NCAM1	46,51	neuronal cell adhesion molecule	NCAM1	4897	4897	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of neuronal_cell_adhesion_molecule -LRB- NCAM1 -RRB- variants on suicidal behaviour and correlated traits .
10828070	0	neuronal_cell_adhesion_molecule	14,45	NF-kappa_B	60,70	neuronal cell adhesion molecule	NF-kappa B	4897	4790	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of neuronal_cell_adhesion_molecule expression by NF-kappa_B .
18664314	0	neuronal_cell_adhesion_molecule	19,50	NRCAM	52,57	neuronal cell adhesion molecule	NRCAM	4897	4897	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the neuronal_cell_adhesion_molecule -LRB- NRCAM -RRB- gene variants with autism .
9852961	0	neuronal_leucine-rich_repeat_protein	57,93	XNLRR-1	21,28	neuronal leucine-rich repeat protein	XNLRR-1	16979(Tax:10090)	379684(Tax:8355)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Molecular cloning of XNLRR-1 , a Xenopus homolog of mouse neuronal_leucine-rich_repeat_protein expressed in the developing Xenopus nervous system .
18591937	0	neuronal_leucine-rich_repeat_protein-1	70,108	NLRR1	110,115	neuronal leucine-rich repeat protein-1	NLRR1	57633	57633	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	N-MYC promotes cell proliferation through a direct transactivation of neuronal_leucine-rich_repeat_protein-1 -LRB- NLRR1 -RRB- gene in neuroblastoma .
9921897	0	neuronal_nicotinic_acetylcholine_receptor_beta2	28,75	CHRNB2	103,109	neuronal nicotinic acetylcholine receptor beta2	CHRNB2	1141	1141	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The structures of the human neuronal_nicotinic_acetylcholine_receptor_beta2 - and alpha3-subunit genes -LRB- CHRNB2 and CHRNA3 -RRB- .
21965681	0	neuronal_nitric-oxide_synthase	37,67	Plasma_membrane_calcium_pump	0,28	neuronal nitric-oxide synthase	Plasma membrane calcium pump	4842	491	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	Plasma_membrane_calcium_pump -LRB- PMCA4 -RRB- - neuronal_nitric-oxide_synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain .
9353265	0	neuronal_nitric-oxide_synthase	15,45	caveolin-3	51,61	neuronal nitric-oxide synthase	caveolin-3	24598(Tax:10116)	29161(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of neuronal_nitric-oxide_synthase with caveolin-3 in skeletal muscle .
17485271	0	neuronal_nuclei	74,89	DP58	0,4	neuronal nuclei	DP58	52897(Tax:10090)	218440(Tax:10090)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	DP58 , an inducible myeloid protein , is constitutively expressed in murine neuronal_nuclei .
19713214	0	neuronal_nuclei	18,33	Fox-3	44,49	neuronal nuclei	Fox-3	146713	146713	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of neuronal_nuclei -LRB- NeuN -RRB- as Fox-3 , a new member of the Fox-1 gene family of splicing factors .
19751214	0	neuronal_nuclei	51,66	neurogranin	36,47	neuronal nuclei	neurogranin	287847(Tax:10116)	64356(Tax:10116)	Gene	Gene	translocation|nmod|START_ENTITY translocation|nmod|END_ENTITY	Activity-dependent translocation of neurogranin to neuronal_nuclei .
21742036	0	neuronatin	74,84	malin	32,37	neuronatin	malin	4826	378884	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Lafora_disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis .
2249478	0	neurone-specific_enolase	16,40	ENO2	42,46	neurone-specific enolase	ENO2	2026	2026	Gene	Gene	Localisation|nmod|START_ENTITY Localisation|appos|END_ENTITY	Localisation of neurone-specific_enolase -LRB- ENO2 -RRB- to 12p13 .
23418070	0	neuropathy_target_esterase	43,69	NTE	71,74	neuropathy target esterase	NTE	10908	10908	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Association of sick_building_syndrome with neuropathy_target_esterase -LRB- NTE -RRB- activity in Japanese .
25255935	0	neuropathy_target_esterase	25,51	NTE	53,56	neuropathy target esterase	NTE	10908	10908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Silencing of PNPLA6 , the neuropathy_target_esterase -LRB- NTE -RRB- codifying gene , alters neurodifferentiation of human embryonal_carcinoma stem cells -LRB- NT2 -RRB- .
8025254	0	neuropeptide	52,64	Brain-derived_neurotrophic_factor	0,33	neuropeptide	Brain-derived neurotrophic factor	379044(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor enhances striatal neuropeptide expression in both the intact and the dopamine-depleted rat striatum .
9869608	0	neuropeptide	46,58	orphanin_FQ	60,71	neuropeptide	orphanin FQ	379044(Tax:10116)	25516(Tax:10116)	Gene	Gene	significance|nmod|START_ENTITY END_ENTITY|nsubj|significance	Functional significance of a newly discovered neuropeptide , orphanin_FQ , in rat gastrointestinal motility .
16377459	0	neuropeptide-Y	4,18	Y5_receptor	19,30	neuropeptide-Y	Y5 receptor	4852	4889	Gene	Gene	antagonist|amod|START_ENTITY antagonist|amod|END_ENTITY	The neuropeptide-Y Y5_receptor antagonist L-152 ,804 decreases alcohol self-administration in inbred alcohol-preferring -LRB- iP -RRB- rats .
7988469	0	neuropeptide-Y	68,82	c-fos	41,46	neuropeptide-Y	c-fos	24604(Tax:10116)	314322(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Growth_hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats .
8218649	0	neuropeptide-Y	33,47	proopiomelanocortin	49,68	neuropeptide-Y	proopiomelanocortin	443508(Tax:9940)	443212(Tax:9940)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Influence of food restriction on neuropeptide-Y , proopiomelanocortin , and luteinizing hormone-releasing hormone gene expression in sheep_hypothalami .
17107711	0	neuropeptide_FF	12,27	NPFF	29,33	neuropeptide FF	NPFF	60337(Tax:10116)	60337(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of neuropeptide_FF -LRB- NPFF -RRB- in the expression of sensitization to hyperlocomotor effect of morphine and ethanol .
18276024	0	neuropeptide_FF	14,29	NPFF	31,35	neuropeptide FF	NPFF	54615(Tax:10090)	54615(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of neuropeptide_FF -LRB- NPFF -RRB- - induced hypothermia and anti-morphine analgesia by RF9 , a new selective NPFF receptors antagonist .
20381562	0	neuropeptide_FF	16,31	NPFF	33,37	neuropeptide FF	NPFF	60337(Tax:10116)	60337(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of neuropeptide_FF -LRB- NPFF -RRB- receptors in correlation with morphine-induced reward in the rat brain .
22197492	0	neuropeptide_FF	14,29	NPFF	31,35	neuropeptide FF	NPFF	60337(Tax:10116)	60337(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Modulation of neuropeptide_FF -LRB- NPFF -RRB- receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats .
15121216	0	neuropeptide_FF	40,55	NPFF2	34,39	neuropeptide FF	NPFF2	104443(Tax:10090)	104443(Tax:10090)	Gene	Gene	density|compound|START_ENTITY density|compound|END_ENTITY	Opposite alterations of NPFF1 and NPFF2 neuropeptide_FF receptor density in the triple MOR/DOR/KOR-opioid receptor knockout mouse brains .
22375000	0	neuropeptide_FF	108,123	NPFF2	125,130	neuropeptide FF	NPFF2	10886	10886	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	GRK2 protein-mediated transphosphorylation contributes to loss of function of - opioid receptors induced by neuropeptide_FF -LRB- NPFF2 -RRB- receptors .
1311427	0	neuropeptide_K	29,43	neurokinin_A	72,84	neuropeptide K	neurokinin A	6863	6863	Gene	Gene	effects|nmod|START_ENTITY Comparison|nmod|effects Comparison|nmod|END_ENTITY	Comparison of the effects of neuropeptide_K and neuropeptide_gamma with neurokinin_A at NK2_receptors in the hamster urinary bladder .
22078257	0	neuropeptide_S	47,61	NPSR1	77,82	neuropeptide S	NPSR1	594857	387129	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The functional coding variant Asn107Ile of the neuropeptide_S receptor gene -LRB- NPSR1 -RRB- is associated with schizophrenia and modulates verbal memory and the acoustic startle response .
19325992	0	neuropeptide_S_receptor_1	28,53	NPSR1	60,65	neuropeptide S receptor 1	NPSR1	387129	387129	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between neuropeptide_S_receptor_1 gene -LRB- NPSR1 -RRB- and eczema in five European populations .
12130646	0	neuropeptide_W	18,32	GPR7	97,101	neuropeptide W	GPR7	283869	2831	Gene	Gene	Identification|nmod|START_ENTITY ligand|nsubj|Identification ligand|nmod|END_ENTITY	Identification of neuropeptide_W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8 .
17052748	0	neuropeptide_Y	79,93	Alpha-melanocyte_stimulating_hormone	0,36	neuropeptide Y	Alpha-melanocyte stimulating hormone	24604(Tax:10116)	24664(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	Alpha-melanocyte_stimulating_hormone antagonizes antidepressant-like effect of neuropeptide_Y in Porsolt 's test in rats .
10338311	0	neuropeptide_Y	182,196	Brain-derived_neurotrophic_factor	0,33	neuropeptide Y	Brain-derived neurotrophic factor	24604(Tax:10116)	24225(Tax:10116)	Gene	Gene	changes|acl|START_ENTITY evolution|nmod|changes immunoreactivity|dep|evolution immunoreactivity|amod|END_ENTITY	Brain-derived_neurotrophic_factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions : temporal evolution of changes as compared to neuropeptide_Y .
15157984	0	neuropeptide_Y	16,30	C-fos	0,5	neuropeptide Y	C-fos	109648(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	C-fos regulates neuropeptide_Y expression in mouse dentate gyrus .
1313731	0	neuropeptide_Y	78,92	CA1	144,147	neuropeptide Y	CA1	24604(Tax:10116)	310218(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	4-Aminopyridine and low Ca2 + differentiate presynaptic inhibition mediated by neuropeptide_Y , baclofen and 2-chloroadenosine in rat hippocampal CA1 in vitro .
8616513	0	neuropeptide_Y	11,25	CA1	54,57	neuropeptide Y	CA1	24604(Tax:10116)	310218(Tax:10116)	Gene	Gene	START_ENTITY|nmod|potentials potentials|nmod|region region|compound|END_ENTITY	Effects of neuropeptide_Y on evoked potentials in the CA1 region and the dentate gyrus of the rat hippocampal slice .
2388526	0	neuropeptide_Y	22,36	CRF	46,49	neuropeptide Y	CRF	24604(Tax:10116)	81648(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Inhibitory effects of neuropeptide_Y -LRB- NPY -RRB- on CRF and stress-induced cecal motor response in rats .
9439821	0	neuropeptide_Y	26,40	CRF	91,94	neuropeptide Y	CRF	24604(Tax:10116)	81648(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes of immunoreactive neuropeptide_Y , somatostatin and corticotropin-releasing_factor -LRB- CRF -RRB- in the brain of a novel epileptic mutant rat , Ihara 's _ genetically_epileptic_rat -LRB- IGER -RRB- .
17030186	0	neuropeptide_Y	96,110	Glial-derived_neurotrophic_factor	0,33	neuropeptide Y	Glial-derived neurotrophic factor	109648(Tax:10090)	14573(Tax:10090)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Glial-derived_neurotrophic_factor modulates enteric neuronal survival and proliferation through neuropeptide_Y .
9790225	0	neuropeptide_Y	97,111	Growth_hormone	0,14	neuropeptide Y	Growth hormone	24604(Tax:10116)	81668(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY acting|nmod|neurons inhibits|advcl|acting inhibits|nsubj|END_ENTITY	Growth_hormone inhibits its own secretion by acting on the hypothalamus through its receptors on neuropeptide_Y neurons in the arcuate_nucleus and somatostatin neurons in the periventricular nucleus .
11277982	0	neuropeptide_Y	40,54	Interleukin-1beta	0,17	neuropeptide Y	Interleukin-1beta	4852	3553	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1beta induces expression of neuropeptide_Y in primary astrocyte cultures in a cytokine-specific manner : induction in human but not rat astrocytes .
10102700	0	neuropeptide_Y	51,65	Leptin	0,6	neuropeptide Y	Leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY subpopulation|nmod|neurons identifies|dobj|subpopulation identifies|nsubj|mRNA mRNA|compound|END_ENTITY	Leptin receptor mRNA identifies a subpopulation of neuropeptide_Y neurons activated by fasting in rat hypothalamus .
15036374	0	neuropeptide_Y	62,76	Leptin	0,6	neuropeptide Y	Leptin	504216(Tax:9913)	280836(Tax:9913)	Gene	Gene	effects|nmod|START_ENTITY attenuates|dobj|effects attenuates|nsubj|END_ENTITY	Leptin attenuates the acute effects of centrally administered neuropeptide_Y on somatotropin but not gonadotropin secretion in ovariectomized cows .
19009650	0	neuropeptide_Y	100,114	Leptin	0,6	neuropeptide Y	Leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY signaling|nmod|neurons +|acl|signaling regulation|nmod|+ orexin|nmod|regulation antagonizes|dobj|orexin antagonizes|nsubj|END_ENTITY	Leptin transiently antagonizes ghrelin and long-lastingly orexin in regulation of Ca2 + signaling in neuropeptide_Y neurons of the arcuate nucleus .
21541626	0	neuropeptide_Y	19,33	N-myc	183,188	neuropeptide Y	N-myc	4852	4613	Gene	Gene	receptor|amod|START_ENTITY expression|nmod|receptor END_ENTITY|nsubj|expression	Gene expression of neuropeptide_Y and neuropeptide-Y1 receptor in relation to proto-oncogene tyrosine_kinase_A , nerve-growth-factor low-affinity-receptor and the transcription factor N-myc in human neuroblastomas .
10921011	0	neuropeptide_Y	8,22	NPY	24,27	neuropeptide Y	NPY	4852	4852	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Plasma neuropeptide_Y -LRB- NPY -RRB- levels in patients with gastric_and_colorectal_carcinomas -RSB- .
11124908	0	neuropeptide_Y	40,54	NPY	82,85	neuropeptide Y	NPY	4852	4852	Gene	Gene	Structure|nmod|START_ENTITY Structure|dep|comparison comparison|nmod|END_ENTITY	Structure and dynamics of micelle-bound neuropeptide_Y : comparison with unligated NPY and implications for receptor selection .
11458203	0	neuropeptide_Y	11,25	NPY	27,30	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- , galanin and vasoactive intestinal peptide -LRB- VIP -RRB- on pituitary hormone release and on ovarian steroidogenesis .
11606443	0	neuropeptide_Y	20,34	NPY	36,39	neuropeptide Y	NPY	4852	4852	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Novel expression of neuropeptide_Y -LRB- NPY -RRB- mRNA in hypothalamic regions during development : region-specific effects of maternal deprivation on NPY and Agouti-related_protein mRNA .
12005258	0	neuropeptide_Y	21,35	NPY	37,40	neuropeptide Y	NPY	4852	4852	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of hypothalamic neuropeptide_Y -LRB- NPY -RRB- in the change of feeding behavior induced by repeated treatment of amphetamine .
15897713	0	neuropeptide_Y	46,60	NPY	62,65	neuropeptide Y	NPY	4852	4852	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel single nucleotide polymorphism of the neuropeptide_Y -LRB- NPY -RRB- gene associated with alcohol_dependence .
15926114	0	neuropeptide_Y	28,42	NPY	44,47	neuropeptide Y	NPY	4852	4852	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Leu7Pro polymorphism in the neuropeptide_Y -LRB- NPY -RRB- gene is associated with impaired_glucose_tolerance and type 2 diabetes in Swedish men .
16160600	0	neuropeptide_Y	24,38	NPY	40,43	neuropeptide Y	NPY	475257(Tax:9615)	475257(Tax:9615)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of endogenous neuropeptide_Y -LRB- NPY -RRB- on the sympathetic-parasympathetic interaction in the canine heart .
1635665	0	neuropeptide_Y	21,35	NPY	37,40	neuropeptide Y	NPY	504216(Tax:9913)	504216(Tax:9913)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of dopamine-beta-hydroxylase .
16380708	0	neuropeptide_Y	54,68	NPY	70,73	neuropeptide Y	NPY	4852	4852	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Sibutramine therapy in obese women -- effects on plasma neuropeptide_Y -LRB- NPY -RRB- , insulin , leptin and beta-endorphin concentrations .
1955194	0	neuropeptide_Y	47,61	NPY	63,66	neuropeptide Y	NPY	475257(Tax:9615)	475257(Tax:9615)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Clonidine but not propranolol decreases plasma neuropeptide_Y -LRB- NPY -RRB- levels .
20691708	0	neuropeptide_Y	50,64	NPY	66,69	neuropeptide Y	NPY	4852	4852	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The Leu7Pro polymorphism of the signal peptide of neuropeptide_Y -LRB- NPY -RRB- gene is associated with increased levels of inflammatory markers preceding vascular_complications in patients with type 2 diabetes .
2113859	0	neuropeptide_Y	22,36	NPY	38,41	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Physiological role of neuropeptide_Y -LRB- NPY -RRB- in control of anterior pituitary hormone release in the rat .
21473895	0	neuropeptide_Y	29,43	NPY	45,48	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Intraperitoneal injection of neuropeptide_Y -LRB- NPY -RRB- alters neurotrophin rat hypothalamic levels : Implications for NPY potential role in stress-related disorders .
2188228	0	neuropeptide_Y	39,53	NPY	55,58	neuropeptide Y	NPY	4852	4852	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	An immunohistochemical localization of neuropeptide_Y -LRB- NPY -RRB- in its amidated form in human frontal cortex .
2388526	0	neuropeptide_Y	22,36	NPY	38,41	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Inhibitory effects of neuropeptide_Y -LRB- NPY -RRB- on CRF and stress-induced cecal motor response in rats .
23994577	0	neuropeptide_Y	71,85	NPY	87,90	neuropeptide Y	NPY	4852	4852	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide_Y -LRB- NPY -RRB- expression in the human SH-SY5Y neuroblastoma cell line .
25221996	0	neuropeptide_Y	15,29	NPY	31,34	neuropeptide Y	NPY	4852	4852	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of neuropeptide_Y -LRB- NPY -RRB- , interleukin-1B -LRB- IL1B -RRB- genetic variants and correlation of IL1B transcript levels with vitiligo susceptibility .
2747854	0	neuropeptide_Y	29,43	NPY	45,48	neuropeptide Y	NPY	100724008	100724008	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Bronchoconstrictor action of neuropeptide_Y -LRB- NPY -RRB- in isolated guinea_pig airways .
2852058	0	neuropeptide_Y	46,60	NPY	62,65	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Quantitative autoradiographic localization of neuropeptide_Y -LRB- NPY -RRB- binding sites in rat posterior pituitary lobe .
3018392	0	neuropeptide_Y	11,25	NPY	27,30	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- at the sympathetic neuroeffector junction .
3108675	0	neuropeptide_Y	11,25	NPY	27,30	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of neuropeptide_Y -LRB- NPY -RRB- induced by tyramine in the isolated vas deferens of rat .
3212674	0	neuropeptide_Y	8,22	NPY	24,27	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of neuropeptide_Y -LRB- NPY -RRB- in cardiovascular responses to stress .
3591369	0	neuropeptide_Y	11,25	NPY	27,30	neuropeptide Y	NPY	100724008	100724008	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- on isolated guinea-pig heart .
3754818	0	neuropeptide_Y	28,42	NPY	44,47	neuropeptide Y	NPY	100301542(Tax:9986)	100301542(Tax:9986)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Tyramine-induced release of neuropeptide_Y -LRB- NPY -RRB- in isolated rabbit intestine .
3839860	0	neuropeptide_Y	26,40	NPY	42,45	neuropeptide Y	NPY	475257(Tax:9615)	475257(Tax:9615)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Vasoconstrictor effect of neuropeptide_Y -LRB- NPY -RRB- on canine coronary artery .
3914636	0	neuropeptide_Y	11,25	NPY	27,30	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- on the release of anterior pituitary hormones in the rat .
6091417	0	neuropeptide_Y	11,25	NPY	27,30	neuropeptide Y	NPY	100724008	100724008	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of neuropeptide_Y -LRB- NPY -RRB- on mechanical activity and neurotransmission in the heart , vas deferens and urinary bladder of the guinea-pig .
6382043	0	neuropeptide_Y	55,69	NPY	71,74	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Electron microscope immunocytochemical localization of neuropeptide_Y -LRB- NPY -RRB- in the rat brain .
6386172	0	neuropeptide_Y	35,49	NPY	51,54	neuropeptide Y	NPY	4852	4852	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of neuropeptide_Y -LRB- NPY -RRB- in the human hypothalamus .
6548713	0	neuropeptide_Y	14,28	NPY	30,33	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of neuropeptide_Y -LRB- NPY -RRB- binding by guanine_nucleotides in the rat cerebral cortex .
7685440	0	neuropeptide_Y	32,46	NPY	48,51	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Depressor effect of intrathecal neuropeptide_Y -LRB- NPY -RRB- Is mediated by Y2 subtype of NPY receptors .
7707867	0	neuropeptide_Y	30,44	NPY	46,49	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Adrenal steroid regulation of neuropeptide_Y -LRB- NPY -RRB- mRNA : differences between dentate hilus and locus coeruleus and arcuate nucleus .
7909929	0	neuropeptide_Y	21,35	NPY	37,40	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of tyrosine_hydroxylase .
8564255	0	neuropeptide_Y	20,34	NPY	36,39	neuropeptide Y	NPY	4852	4852	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Characterization of neuropeptide_Y -LRB- NPY -RRB- receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226 .
8584757	0	neuropeptide_Y	61,75	NPY	77,80	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Central administration of antisense oligodeoxynucleotides to neuropeptide_Y -LRB- NPY -RRB- mRNA reveals the critical role of newly synthesized NPY in regulation of LHRH release .
8743297	0	neuropeptide_Y	29,43	NPY	45,48	neuropeptide Y	NPY	4852	4852	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Epitopic characterization of neuropeptide_Y -LRB- NPY -RRB- by alanine-scanning mutagenesis .
9013028	0	neuropeptide_Y	24,38	NPY	40,43	neuropeptide Y	NPY	4852	4852	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Transient expression of neuropeptide_Y -LRB- NPY -RRB- immunoreactivity in the developing hamster paraventricular thalamic area is due to apoptosis .
9802416	0	neuropeptide_Y	11,25	NPY	27,30	neuropeptide Y	NPY	24604(Tax:10116)	24604(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Suppressed neuropeptide_Y -LRB- NPY -RRB- mRNA in rat amygdala following restraint stress .
15703301	0	neuropeptide_Y	27,41	NT4	56,59	neuropeptide Y	NT4	4852	4909	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|nmod|END_ENTITY	Transcellular induction of neuropeptide_Y expression by NT4 and BDNF .
8730811	0	neuropeptide_Y	45,59	Nerve_growth_factor	0,19	neuropeptide Y	Nerve growth factor	4852	4803	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Nerve_growth_factor stimulates production of neuropeptide_Y in human lymphocytes .
11911949	0	neuropeptide_Y	40,54	Y1	55,57	neuropeptide Y	Y1	4852	6084	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Intron-mediated expression of the human neuropeptide_Y Y1 receptor .
10342854	0	neuropeptide_Y	73,87	agouti-related_protein	22,44	neuropeptide Y	agouti-related protein	4852	181	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Altered expression of agouti-related_protein and its colocalization with neuropeptide_Y in the arcuate nucleus of the hypothalamus during lactation .
10712639	0	neuropeptide_Y	18,32	brain-derived_neurotrophic_factor	44,77	neuropeptide Y	brain-derived neurotrophic factor	24604(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Overexpression of neuropeptide_Y induced by brain-derived_neurotrophic_factor in the rat hippocampus is long lasting .
11689163	0	neuropeptide_Y	56,70	brain-derived_neurotrophic_factor	101,134	neuropeptide Y	brain-derived neurotrophic factor	24604(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cultures cultures|nmod|END_ENTITY	Induction of functional and morphological expression of neuropeptide_Y -LRB- NPY -RRB- in cortical cultures by brain-derived_neurotrophic_factor -LRB- BDNF -RRB- : evidence for a requirement for extracellular-regulated_kinase -LRB- ERK -RRB- - dependent and ERK-independent mechanisms .
9677306	0	neuropeptide_Y	15,29	brain-derived_neurotrophic_factor	49,82	neuropeptide Y	brain-derived neurotrophic factor	24604(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of neuropeptide_Y gene expression by brain-derived_neurotrophic_factor requires both the phospholipase Cgamma and Shc binding sites on its receptor , TrkB .
7719725	0	neuropeptide_Y	115,129	c-fos	0,5	neuropeptide Y	c-fos	24604(Tax:10116)	314322(Tax:10116)	Gene	Gene	infusions|nmod|START_ENTITY hypothalamus|nmod|infusions nucleus|nmod|hypothalamus expression|nmod|nucleus expression|amod|END_ENTITY	c-fos expression in the paraventricular nucleus of the hypothalamus following intracerebroventricular infusions of neuropeptide_Y .
7895063	0	neuropeptide_Y	70,84	c-fos	0,5	neuropeptide Y	c-fos	24604(Tax:10116)	314322(Tax:10116)	Gene	Gene	administration|nmod|START_ENTITY brain|nmod|administration expression|nmod|brain expression|amod|END_ENTITY	c-fos expression in the rat brain following central administration of neuropeptide_Y and effects of food consumption .
8750890	0	neuropeptide_Y	128,142	c-fos	95,100	neuropeptide Y	c-fos	24604(Tax:10116)	314322(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY subpopulation|nmod|neurons gene|nmod|subpopulation gene|amod|END_ENTITY	Central glucoprivation evoked by administration of 2-deoxy-D-glucose induces expression of the c-fos gene in a subpopulation of neuropeptide_Y neurons in the rat hypothalamus .
8782903	0	neuropeptide_Y	32,46	c-fos	23,28	neuropeptide Y	c-fos	24604(Tax:10116)	314322(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Prolonged induction of c-fos in neuropeptide_Y - and somatostatin-immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation .
1635665	0	neuropeptide_Y	21,35	dopamine-beta-hydroxylase	70,95	neuropeptide Y	dopamine-beta-hydroxylase	504216(Tax:9913)	280758(Tax:9913)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of dopamine-beta-hydroxylase .
22093818	0	neuropeptide_Y	28,42	growth_hormone	44,58	neuropeptide Y	growth hormone	4852	2688	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	A higher response of plasma neuropeptide_Y , growth_hormone , leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose_tissue to Acipimox during exercise in patients with bulimia_nervosa : single-blind , randomized , microdialysis study .
23090692	0	neuropeptide_Y	24,38	growth_hormone	71,85	neuropeptide Y	growth hormone	24604(Tax:10116)	81668(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|pulses pulses|amod|END_ENTITY	Possible involvement of neuropeptide_Y in photo-induced suppression of growth_hormone pulses .
7690118	0	neuropeptide_Y	116,130	growth_hormone	134,148	neuropeptide Y	growth hormone	24604(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|pattern pattern|amod|END_ENTITY	Effect of parenteral administration of selected nutrients and central injection of gamma-globulin from antiserum to neuropeptide_Y on growth_hormone secretory pattern in food-deprived rats .
8884982	0	neuropeptide_Y	21,35	growth_hormone	39,53	neuropeptide Y	growth hormone	24604(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Inhibitory effect of neuropeptide_Y on growth_hormone secretion in rats is mediated by both Y1 - and Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial_basal_hypothalamus .
8923503	0	neuropeptide_Y	15,29	growth_hormone	33,47	neuropeptide Y	growth hormone	4852	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Stimulation by neuropeptide_Y of growth_hormone secretion in prolactinoma in vivo .
9574834	0	neuropeptide_Y	38,52	growth_hormone	56,70	neuropeptide Y	growth hormone	4852	2688	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|secretion secretion|amod|END_ENTITY	Stimulatory and inhibitory effects of neuropeptide_Y on growth_hormone secretion in acromegaly in vivo .
19309436	0	neuropeptide_Y	125,139	interleukin-1beta	98,115	neuropeptide Y	interleukin-1beta	4852	3553	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|cells cells|nmod|END_ENTITY	Regulation of catecholamine release and tyrosine_hydroxylase in human adrenal chromaffin cells by interleukin-1beta : role of neuropeptide_Y and nitric_oxide .
12372004	0	neuropeptide_Y	144,158	leptin	123,129	neuropeptide Y	leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	neurones|amod|START_ENTITY associated|nmod|neurones associated|nmod|development development|nmod|resistance resistance|compound|END_ENTITY	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
12372004	0	neuropeptide_Y	144,158	leptin	36,42	neuropeptide Y	leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	neurones|amod|START_ENTITY associated|nmod|neurones associated|nsubjpass|Resistance Resistance|nmod|action action|nmod|END_ENTITY	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
12372004	0	neuropeptide_Y	144,158	leptin	69,75	neuropeptide Y	leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	neurones|amod|START_ENTITY associated|nmod|neurones associated|nsubjpass|Resistance Resistance|nmod|action action|nmod|leptin leptin|nmod|infusion infusion|compound|END_ENTITY	Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide_Y neurones .
16006740	0	neuropeptide_Y	111,125	leptin	134,140	neuropeptide Y	leptin	109648(Tax:10090)	16846(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of neuronal genes and its effect on neural functions : transcriptional regulation of neuropeptide_Y gene by leptin and its effect on feeding .
16135994	0	neuropeptide_Y	35,49	leptin	27,33	neuropeptide Y	leptin	4852	3952	Gene	Gene	A|appos|START_ENTITY A|appos|END_ENTITY	Plasma orexin A , orexin B , leptin , neuropeptide_Y -LRB- NPY -RRB- and insulin in obese women .
22093818	0	neuropeptide_Y	28,42	leptin	60,66	neuropeptide Y	leptin	4852	3952	Gene	Gene	levels|compound|START_ENTITY levels|dep|END_ENTITY	A higher response of plasma neuropeptide_Y , growth_hormone , leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose_tissue to Acipimox during exercise in patients with bulimia_nervosa : single-blind , randomized , microdialysis study .
22645062	0	neuropeptide_Y	15,29	leptin	7,13	neuropeptide Y	leptin	4852	3952	Gene	Gene	thickness|advmod|START_ENTITY thickness|nsubj|END_ENTITY	Plasma leptin , neuropeptide_Y , ghrelin , and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate .
23652383	0	neuropeptide_Y	31,45	leptin	95,101	neuropeptide Y	leptin	4852	3952	Gene	Gene	promoter|amod|START_ENTITY polymorphism|nmod|promoter associated|nsubjpass|polymorphism associated|nmod|levels levels|compound|END_ENTITY	Functional polymorphism in the neuropeptide_Y gene promoter -LRB- rs16147 -RRB- is associated with serum leptin levels and waist-hip ratio in women .
9688683	0	neuropeptide_Y	35,49	leptin	15,21	neuropeptide Y	leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	signaling|advmod|START_ENTITY influence|advcl|signaling influence|nsubj|site site|nmod|END_ENTITY	Neural site of leptin influence on neuropeptide_Y signaling pathways altering feeding and uncoupling protein .
9725806	0	neuropeptide_Y	56,70	leptin	32,38	neuropeptide Y	leptin	24604(Tax:10116)	25608(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Aging and fasting regulation of leptin and hypothalamic neuropeptide_Y gene expression .
2160601	0	neuropeptide_Y	34,48	nerve_growth_factor	57,76	neuropeptide Y	nerve growth factor	24604(Tax:10116)	310738(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of the neuropeptide_Y gene by nerve_growth_factor : antagonism by glucocorticoids and potentiation by adenosine_3 ' ,5 ' - monophosphate and phorbol_ester .
8195188	0	neuropeptide_Y	40,54	nerve_growth_factor	63,82	neuropeptide Y	nerve growth factor	4852	4803	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the human neuropeptide_Y gene by nerve_growth_factor .
21346312	0	neuropeptide_Y	26,40	neurotrophin	134,146	neuropeptide Y	neurotrophin	4852	627	Gene	Gene	effect|nmod|START_ENTITY associated|nsubjpass|effect associated|nmod|production production|compound|END_ENTITY	Neuroprotective effect of neuropeptide_Y against b-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production .
8891268	0	neuropeptide_Y	55,69	neurotrophin	14,26	neuropeptide Y	neurotrophin	24604(Tax:10116)	627	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Comparison of neurotrophin regulation of human and rat neuropeptide_Y -LRB- NPY -RRB- neurons : induction of NPY production in aggregate cultures derived from rat but not from human fetal brains .
1901963	0	neuropeptide_Y	72,86	proopiomelanocortin	27,46	neuropeptide Y	proopiomelanocortin	24604(Tax:10116)	24664(Tax:10116)	Gene	Gene	peptides|advmod|START_ENTITY interactions|dep|peptides interactions|nmod|END_ENTITY	Anatomical interactions of proopiomelanocortin -LRB- POMC -RRB- - related peptides , neuropeptide_Y -LRB- NPY -RRB- and dopamine beta-hydroxylase -LRB- D beta H -RRB- fibers and thyrotropin-releasing_hormone -LRB- TRH -RRB- neurons in the paraventricular nucleus of rat hypothalamus .
7773678	0	neuropeptide_Y	53,67	proopiomelanocortin	14,33	neuropeptide Y	proopiomelanocortin	24604(Tax:10116)	24664(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of proopiomelanocortin gene expression by neuropeptide_Y in the rat arcuate nucleus .
1325309	0	neuropeptide_Y	21,35	renin	50,55	neuropeptide Y	renin	24604(Tax:10116)	24715(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	Inhibitory effect of neuropeptide_Y on stimulated renin secretion of awake rats .
7909929	0	neuropeptide_Y	21,35	tyrosine_hydroxylase	70,90	neuropeptide Y	tyrosine hydroxylase	24604(Tax:10116)	25085(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|activity activity|nmod|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of tyrosine_hydroxylase .
17235527	0	neuropeptide_Y2_receptor	39,63	NPY2R	65,70	neuropeptide Y2 receptor	NPY2R	4887	4887	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in the neuropeptide_Y2_receptor -LRB- NPY2R -RRB- gene and association with severe obesity in French white subjects .
17992642	0	neuropeptide_Y2_receptor	43,67	NPY2R	69,74	neuropeptide Y2 receptor	NPY2R	4887	4887	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association of sequence variants in the neuropeptide_Y2_receptor -LRB- NPY2R -RRB- gene with early onset obesity in Germans .
3351430	0	neuropeptide_tyrosine_Y	17,40	NPY	42,45	neuropeptide tyrosine Y	NPY	4852	4852	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Plasma levels of neuropeptide_tyrosine_Y -LRB- NPY -RRB- are increased in human sepsis but are unchanged during canine endotoxin shock despite raised catecholamine concentrations .
2572126	0	neurophysin-II	7,21	prolactin	33,42	neurophysin-II	prolactin	280728(Tax:9913)	24683(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|compound|END_ENTITY	Bovine neurophysin-II stimulates prolactin release without involvement of dopaminergic prolactin-release inhibiting factor receptor in the estradiol-primed male rat .
3344067	0	neurophysin_II	8,22	growth_hormone	35,49	neurophysin II	growth hormone	280728(Tax:9913)	81668(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|amod|END_ENTITY	Bovine ` neurophysin_II ' stimulates growth_hormone release in the estradiol-primed male rat .
21525791	0	neuropilin-1	95,107	AR	91,93	neuropilin-1	AR	8829	367	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	TOFA -LRB- 5-tetradecyl-oxy-2-furoic_acid -RRB- reduces fatty_acid synthesis , inhibits expression of AR , neuropilin-1 and Mcl-1 and kills prostate_cancer cells independent of p53 status .
25772243	0	neuropilin-1	22,34	GPNMB	0,5	neuropilin-1	GPNMB	8829	10457	Gene	Gene	cooperates|advcl|START_ENTITY cooperates|nsubj|END_ENTITY	GPNMB cooperates with neuropilin-1 to promote mammary_tumor growth and engages integrin a5b1 for efficient breast_cancer metastasis .
18223683	0	neuropilin-1	30,42	Galectin-1	0,10	neuropilin-1	Galectin-1	8829	3956	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	Galectin-1 , a novel ligand of neuropilin-1 , activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells .
23621014	0	neuropilin-1	35,47	NRP-1	49,54	neuropilin-1	NRP-1	8829	8829	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression and significance of neuropilin-1 -LRB- NRP-1 -RRB- on glioma cell lines and glioma tissues .
25231404	0	neuropilin-1	89,101	STAT5A	117,123	neuropilin-1	STAT5A	18186(Tax:10090)	20850(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Calreticulin promotes migration and invasion of esophageal_cancer cells by up-regulating neuropilin-1 expression via STAT5A .
21945444	0	neuropilin-1	46,58	Semaphorin_3A	0,13	neuropilin-1	Semaphorin 3A	8829	10371	Gene	Gene	binding|advcl|START_ENTITY peptide|xcomp|binding peptide|nsubj|hybrid hybrid|amod|END_ENTITY	Semaphorin_3A lytic hybrid peptide binding to neuropilin-1 as a novel anti-cancer agent in pancreatic_cancer .
24918638	0	neuropilin-1	32,44	Semaphorin_3A	0,13	neuropilin-1	Semaphorin 3A	18186(Tax:10090)	20346(Tax:10090)	Gene	Gene	signaling|advcl|START_ENTITY END_ENTITY|acl|signaling	Semaphorin_3A signaling through neuropilin-1 is an early trigger for distal axonopathy in the SOD1G93A mouse model of amyotrophic_lateral_sclerosis .
18922901	0	neuropilin-1	77,89	Semaphorin_3B	0,13	neuropilin-1	Semaphorin 3B	8829	7869	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Semaphorin_3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast_cancer cells .
11756651	0	neuropilin-1	23,35	VEGF	75,79	neuropilin-1	VEGF	18186(Tax:10090)	22339(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	Selective induction of neuropilin-1 by vascular_endothelial_growth_factor -LRB- VEGF -RRB- : a mechanism contributing to VEGF-induced angiogenesis .
12453880	0	neuropilin-1	96,108	VEGF	129,133	neuropilin-1	VEGF	18186(Tax:10090)	22339(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY administration|nmod|vascular_endothelial_growth_factor predicts|nsubj|administration predicts|dobj|role role|nmod|END_ENTITY	In vivo administration of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its antagonist , soluble neuropilin-1 , predicts a role of VEGF in the progression of acute_myeloid_leukemia in vivo .
12453880	0	neuropilin-1	96,108	VEGF	62,66	neuropilin-1	VEGF	18186(Tax:10090)	22339(Tax:10090)	Gene	Gene	vascular_endothelial_growth_factor|amod|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	In vivo administration of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its antagonist , soluble neuropilin-1 , predicts a role of VEGF in the progression of acute_myeloid_leukemia in vivo .
15233640	0	neuropilin-1	51,63	VEGF	36,40	neuropilin-1	VEGF	8829	7422	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor neuropilin-1 's distribution in astrocytic_tumors .
15708957	0	neuropilin-1	76,88	VEGF	24,28	neuropilin-1	VEGF	8829	7422	Gene	Gene	presence|nmod|START_ENTITY receptor|nmod|presence VEGF|dobj|receptor isoforms|xcomp|VEGF isoforms|nsubj|Differential Differential|nmod|END_ENTITY	Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1 : a computational model .
15708957	0	neuropilin-1	76,88	VEGF	41,45	neuropilin-1	VEGF	8829	7422	Gene	Gene	presence|nmod|START_ENTITY receptor|nmod|presence END_ENTITY|dobj|receptor	Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1 : a computational model .
16289960	0	neuropilin-1	16,28	VEGF	125,129	neuropilin-1	VEGF	8829	7422	Gene	Gene	Upregulation|nmod|START_ENTITY enhances|nsubj|Upregulation enhances|xcomp|vascular vascular|nmod|END_ENTITY	Upregulation of neuropilin-1 by basic_fibroblast_growth_factor enhances vascular smooth muscle cell migration in response to VEGF .
17196035	0	neuropilin-1	10,22	VEGF	34,38	neuropilin-1	VEGF	8829	7422	Gene	Gene	START_ENTITY|xcomp|inhibit inhibit|dobj|END_ENTITY	Targeting neuropilin-1 to inhibit VEGF signaling in cancer : Comparison of therapeutic approaches .
17917967	0	neuropilin-1	71,83	VEGF	46,50	neuropilin-1	VEGF	8829	7422	Gene	Gene	NRP-1|amod|START_ENTITY receptors|nmod|NRP-1 receptors|amod|END_ENTITY	Myeloid_leukemias express a broad spectrum of VEGF receptors including neuropilin-1 -LRB- NRP-1 -RRB- and NRP-2 .
17983687	0	neuropilin-1	98,110	VEGF	77,81	neuropilin-1	VEGF	8829	7422	Gene	Gene	simulations|amod|START_ENTITY binding|nmod|simulations END_ENTITY|amod|binding	Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF -LRB- 165 -RRB- binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin -1 complex .
23447383	0	neuropilin-1	19,31	VEGF	4,8	neuropilin-1	VEGF	8829	7422	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The VEGF receptor , neuropilin-1 , represents a promising novel target for chronic_lymphocytic_leukemia patients .
26804176	0	neuropilin-1	23,35	VEGF	103,107	neuropilin-1	VEGF	8829	7422	Gene	Gene	association|nmod|START_ENTITY association|dep|role role|nmod|induction induction|nmod|signaling signaling|compound|END_ENTITY	A novel association of neuropilin-1 and MUC1 in pancreatic_ductal_adenocarcinoma : role in induction of VEGF signaling and angiogenesis .
15233640	0	neuropilin-1	51,63	Vascular_endothelial_growth_factor	0,34	neuropilin-1	Vascular endothelial growth factor	8829	7422	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor neuropilin-1 's distribution in astrocytic_tumors .
18723443	0	neuropilin-1	57,69	Vascular_endothelial_growth_factor	0,34	neuropilin-1	Vascular endothelial growth factor	8829	7422	Gene	Gene	endocytosis|amod|START_ENTITY induce|dobj|endocytosis induce|nsubj|END_ENTITY	Vascular_endothelial_growth_factor and semaphorin induce neuropilin-1 endocytosis via separate pathways .
25777560	0	neuropilin-1	85,97	Vascular_endothelial_growth_factor	0,34	neuropilin-1	Vascular endothelial growth factor	8829	7422	Gene	Gene	signalling|nmod|START_ENTITY factor|advcl|signalling factor|nsubj|END_ENTITY	Vascular_endothelial_growth_factor is an autocrine growth factor , signalling through neuropilin-1 in non-small cell lung_cancer .
25889301	0	neuropilin-1	84,96	Vascular_endothelial_growth_factor	0,34	neuropilin-1	Vascular endothelial growth factor	8829	7422	Gene	Gene	signaling|nmod|START_ENTITY factor|advcl|signaling factor|nsubj|END_ENTITY	Vascular_endothelial_growth_factor is an autocrine growth factor , signaling through neuropilin-1 in non-small cell lung_cancer .
25889301	0	neuropilin-1	84,96	Vascular_endothelial_growth_factor	0,34	neuropilin-1	Vascular endothelial growth factor	8829	7422	Gene	Gene	signaling|nmod|START_ENTITY factor|advcl|signaling factor|nsubj|END_ENTITY	Vascular_endothelial_growth_factor is an autocrine growth factor , signaling through neuropilin-1 in non-small cell lung_cancer .
12618892	0	neuropilin-1	13,25	epidermal_growth_factor	68,91	neuropilin-1	epidermal growth factor	8829	1950	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of neuropilin-1 and vascular_endothelial_growth_factor by epidermal_growth_factor in human gastric_cancer cells .
11886873	0	neuropilin-1	20,32	semaphorin_3A	76,89	neuropilin-1	semaphorin 3A	539369(Tax:9913)	537777(Tax:9913)	Gene	Gene	features|amod|START_ENTITY features|acl:relcl|confer confer|xcomp|binding binding|nmod|END_ENTITY	Characterization of neuropilin-1 structural features that confer binding to semaphorin_3A and vascular endothelial growth factor 165 .
12456642	0	neuropilin-1	38,50	semaphorin_3A	79,92	neuropilin-1	semaphorin 3A	8829	10371	Gene	Gene	control|amod|START_ENTITY L1|nmod|control interactions|nmod|L1 axonal|nsubj|interactions axonal|nmod|END_ENTITY	Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin_3A .
24093675	0	neuropilin-1	102,114	semaphorin_3A	15,28	neuropilin-1	semaphorin 3A	8829	10371	Gene	Gene	diabetic_retinopathy|nmod|START_ENTITY permeability|nmod|diabetic_retinopathy inducer|nmod|permeability inducer|nsubj|END_ENTITY	Neuron-derived semaphorin_3A is an early inducer of vascular permeability in diabetic_retinopathy via neuropilin-1 .
24276892	0	neuropilin-1	12,24	semaphorin_3A	25,38	neuropilin-1	semaphorin 3A	8829	10371	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	The role of neuropilin-1 / semaphorin_3A signaling in lymphatic vessel development and maturation .
10842181	0	neuropilin-1	19,31	vascular_endothelial_growth_factor	37,71	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of neuropilin-1 with vascular_endothelial_growth_factor and its receptor flt-1 .
12910515	0	neuropilin-1	83,95	vascular_endothelial_growth_factor	39,73	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|receptor receptor|compound|END_ENTITY	Expression and regulation of the novel vascular_endothelial_growth_factor receptor neuropilin-1 by epidermal_growth_factor in human pancreatic_carcinoma .
15126502	0	neuropilin-1	145,157	vascular_endothelial_growth_factor	31,65	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	production|amod|START_ENTITY mediated|nmod|production mediated|nsubjpass|effects effects|nmod|END_ENTITY	Anti-chemorepulsive effects of vascular_endothelial_growth_factor and placental_growth_factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production .
15749672	0	neuropilin-1	134,146	vascular_endothelial_growth_factor	27,61	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	produced|nsubjpass|START_ENTITY evidence|dep|produced expression|dep|evidence expression|nmod|END_ENTITY	Differential expression of vascular_endothelial_growth_factor and its receptors in hematopoietic and fatty bone marrow : evidence that neuropilin-1 is produced by fat cells .
16371354	0	neuropilin-1	14,26	vascular_endothelial_growth_factor	83,117	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	START_ENTITY|nmod|sequence sequence|amod|similar similar|nmod|that that|acl|encoded encoded|nmod|exon exon|nmod|END_ENTITY	Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular_endothelial_growth_factor .
16513643	0	neuropilin-1	39,51	vascular_endothelial_growth_factor	101,135	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	antagonist|amod|START_ENTITY Characterization|nmod|antagonist reveals|nsubj|Characterization reveals|dobj|importance importance|nmod|exon exon|compound|END_ENTITY	Characterization of a bicyclic peptide neuropilin-1 -LRB- NP-1 -RRB- antagonist -LRB- EG3287 -RRB- reveals importance of vascular_endothelial_growth_factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling .
17942890	0	neuropilin-1	143,155	vascular_endothelial_growth_factor	88,122	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular_endothelial_growth_factor binding site within neuropilin-1 .
18715621	0	neuropilin-1	87,99	vascular_endothelial_growth_factor	15,49	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	VEGFR-1|dep|START_ENTITY levels|dep|VEGFR-1 levels|nmod|END_ENTITY	High levels of vascular_endothelial_growth_factor and its receptors -LRB- VEGFR-1 , VEGFR-2 , neuropilin-1 -RRB- are associated with worse outcome in breast_cancer .
18996601	0	neuropilin-1	62,74	vascular_endothelial_growth_factor	18,52	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of the vascular_endothelial_growth_factor receptor neuropilin-1 in the human endometrium .
21111525	0	neuropilin-1	62,74	vascular_endothelial_growth_factor	18,52	neuropilin-1	vascular endothelial growth factor	8829	7422	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|receptor receptor|compound|END_ENTITY	Expression of the vascular_endothelial_growth_factor receptor neuropilin-1 at the human embryo-maternal interface .
23436775	0	neuropilin-2	23,35	GLI1	0,4	neuropilin-2	GLI1	8828	2735	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	GLI1 regulates a novel neuropilin-2 / a6b1 integrin based autocrine pathway that contributes to breast_cancer initiation .
17427189	0	neuropilin-2	19,31	NRP2	33,37	neuropilin-2	NRP2	8828	8828	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the neuropilin-2 -LRB- NRP2 -RRB- gene polymorphisms with autism in Chinese Han population .
20651020	0	neuropilin-2	18,30	vascular_endothelial_growth_factor	52,86	neuropilin-2	vascular endothelial growth factor	8828	7422	Gene	Gene	domain|amod|START_ENTITY antagonizes|nsubj|domain antagonizes|dobj|bioactivity bioactivity|compound|END_ENTITY	A mutated soluble neuropilin-2 B domain antagonizes vascular_endothelial_growth_factor bioactivity and inhibits tumor progression .
15160992	0	neuropilin_1	22,34	NRP1	36,40	neuropilin 1	NRP1	8829	8829	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Overexpression of the neuropilin_1 -LRB- NRP1 -RRB- gene correlated with poor prognosis in human glioma .
23452854	0	neuropilin_1	34,46	placental_growth_factor	10,33	neuropilin 1	placental growth factor	8829	5228	Gene	Gene	inhibits|nsubj|START_ENTITY END_ENTITY|parataxis|inhibits	Targeting placental_growth_factor / neuropilin_1 pathway inhibits growth and spread of medulloblastoma .
15378660	0	neuropsin	27,36	neurosin	52,60	neuropsin	neurosin	259277(Tax:10090)	19144(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Differential expression of neuropsin and protease_M / neurosin in oligodendrocytes after injury to the spinal cord .
16209928	0	neuroserpin	64,75	tissue-type_plasminogen_activator	19,52	neuroserpin	tissue-type plasminogen activator	5274	5327	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	The brain-specific tissue-type_plasminogen_activator inhibitor , neuroserpin , protects neurons against excitotoxicity both in vitro and in vivo .
21174006	0	neuroserpin	51,62	tissue_plasminogen_activator	12,40	neuroserpin	tissue plasminogen activator	5274	100128998	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	The natural tissue_plasminogen_activator inhibitor neuroserpin and acute ischaemic_stroke outcome .
26528129	0	neuroserpin	87,98	tissue_plasminogen_activator	40,68	neuroserpin	tissue plasminogen activator	5274	100128998	Gene	Gene	START_ENTITY|nsubj|roles roles|nmod|END_ENTITY	Physiological and pathological roles of tissue_plasminogen_activator and its inhibitor neuroserpin in the nervous system .
12928483	0	neurosin	47,55	Alpha-synuclein	0,15	neurosin	Alpha-synuclein	5653	6622	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Alpha-synuclein degradation by serine protease neurosin : implication for pathogenesis of synucleinopathies .
12480753	0	neurosin	40,48	KLK6	50,54	neurosin	KLK6	5653	5653	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Decreased cerebrospinal fluid levels of neurosin -LRB- KLK6 -RRB- , an aging-related protease , as a possible new risk factor for Alzheimer 's _ disease .
15378660	0	neurosin	52,60	neuropsin	27,36	neurosin	neuropsin	19144(Tax:10090)	259277(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Differential expression of neuropsin and protease_M / neurosin in oligodendrocytes after injury to the spinal cord .
15911126	0	neurosin	38,46	protease_M	27,37	neurosin	protease M	19144(Tax:10090)	19144(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Differential expression of protease_M / neurosin in oligodendrocytes and their progenitors in an animal model of multiple_sclerosis .
23786666	0	neurospecific_enolase	97,118	S100B	131,136	neurospecific enolase	S100B	24334(Tax:10116)	25742(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- An experimental model of mass-type brain_damage in the rat : expression of brain_damage based on neurospecific_enolase and protein S100B -RSB- .
11297813	0	neurotensin	4,15	Fos	76,79	neurotensin	Fos	299757(Tax:10116)	314322(Tax:10116)	Gene	Gene	SR_48692|compound|START_ENTITY attenuates|nsubj|SR_48692 attenuates|dobj|expression expression|compound|END_ENTITY	The neurotensin antagonist SR_48692 attenuates haloperidol-induced striatal Fos expression in the rat .
15150532	0	neurotensin	4,15	Fos	43,46	neurotensin	Fos	299757(Tax:10116)	314322(Tax:10116)	Gene	Gene	PD149163|compound|START_ENTITY increases|nsubj|PD149163 increases|dobj|expression expression|compound|END_ENTITY	The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat .
16632196	0	neurotensin	62,73	Fos	30,33	neurotensin	Fos	67405(Tax:10090)	14281(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY attenuated|nmod|mice attenuated|nsubjpass|expression expression|compound|END_ENTITY	Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice .
6091630	0	neurotensin	41,52	GRF	0,3	neurotensin	GRF	299757(Tax:10116)	29446(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	GRF -LRB- somatocrinin -RRB- stimulates release of neurotensin , calcitonin and cAMP by a rat C cell line .
17116165	0	neurotensin	44,55	NTS1	56,60	neurotensin	NTS1	67405(Tax:10090)	102467591	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Bidirectional regulation of dopamine D2 and neurotensin NTS1 receptors in dopamine neurons .
22504145	0	neurotensin	42,53	NTS1	0,4	neurotensin	NTS1	67405(Tax:10090)	102467591	Gene	Gene	treatment|amod|START_ENTITY analgesia|nmod|treatment mediate|dobj|analgesia mediate|nsubj|END_ENTITY	NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral_pain .
22778874	0	neurotensin	53,64	NTS1	65,69	neurotensin	NTS1	4922	4922	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics .
11032391	0	neurotensin	18,29	NTSR1	45,50	neurotensin	NTSR1	4922	4923	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The high affinity neurotensin receptor gene -LRB- NTSR1 -RRB- : comparative sequencing and association studies in schizophrenia .
23109725	0	neurotensin	27,38	NTSR1	63,68	neurotensin	NTSR1	4922	4923	Gene	Gene	receptors|amod|START_ENTITY expression|nmod|receptors expression|appos|END_ENTITY	Differential expression of neurotensin and specific receptors , NTSR1 and NTSR2 , in normal and malignant human B lymphocytes .
3561863	0	neurotensin	99,110	Neurotensin	0,11	neurotensin	Neurotensin	4922	4922	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|dep|localization	Neurotensin in the human fallopian tube : immunohistochemical localization and effects of synthetic neurotensin on motor activity in vitro .
7724045	0	neurotensin	26,37	Protein_kinase_C	0,16	neurotensin	Protein kinase C	299757(Tax:10116)	24681(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY mediates|dobj|inhibition mediates|nsubj|END_ENTITY	Protein_kinase_C mediates neurotensin inhibition of inwardly rectifying potassium currents in rat substantia nigra dopaminergic neurons .
21508335	0	neurotensin	28,39	mTORC1	0,6	neurotensin	mTORC1	4922	382056(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|increases increases|amod|END_ENTITY	mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON .
11495695	0	neurotensin	44,55	neurotensin	79,90	neurotensin	neurotensin	4922	4922	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	K -LRB- + -RRB- - p-nitrophenylphosphatase inhibition by neurotensin involves high affinity neurotensin receptor : influence of potassium concentration and enzyme phosphorylation .
11495695	0	neurotensin	79,90	neurotensin	44,55	neurotensin	neurotensin	4922	4922	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	K -LRB- + -RRB- - p-nitrophenylphosphatase inhibition by neurotensin involves high affinity neurotensin receptor : influence of potassium concentration and enzyme phosphorylation .
3653250	0	neurotensin	22,33	neurotensin	41,52	neurotensin	neurotensin	100727527	100727527	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of guinea_pig neurotensin -LRB- -LSB- Ser7 -RSB- neurotensin -RRB- on gastrointestinal smooth muscle .
3653250	0	neurotensin	41,52	neurotensin	22,33	neurotensin	neurotensin	100727527	100727527	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of guinea_pig neurotensin -LRB- -LSB- Ser7 -RSB- neurotensin -RRB- on gastrointestinal smooth muscle .
6578671	0	neurotensin	134,145	neurotensin	91,102	neurotensin	neurotensin	4922	4922	Gene	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Relation between lower esophageal sphincter -LRB- LES -RRB- pressure and the plasma concentration of neurotensin during intravenous infusion of neurotensin -LRB- 1-13 -RRB- and -LRB- Gln4 -RRB- neurotensin -LRB- 1-13 -RRB- in man .
6578671	0	neurotensin	91,102	neurotensin	134,145	neurotensin	neurotensin	4922	4922	Gene	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Relation between lower esophageal sphincter -LRB- LES -RRB- pressure and the plasma concentration of neurotensin during intravenous infusion of neurotensin -LRB- 1-13 -RRB- and -LRB- Gln4 -RRB- neurotensin -LRB- 1-13 -RRB- in man .
6698252	0	neurotensin	11,22	neurotensin	35,46	neurotensin	neurotensin	611687(Tax:9615)	611687(Tax:9615)	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	-LSB- Effect of neurotensin and -LRB- DTr11 -RRB- - neurotensin on the secretory function of the pancreas -RSB- .
6698252	0	neurotensin	35,46	neurotensin	11,22	neurotensin	neurotensin	611687(Tax:9615)	611687(Tax:9615)	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of neurotensin and -LRB- DTr11 -RRB- - neurotensin on the secretory function of the pancreas -RSB- .
15123666	0	neurotensin	32,43	protein_kinase_D	12,28	neurotensin	protein kinase D	4922	5587	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	The role of protein_kinase_D in neurotensin secretion mediated by protein_kinase_C-alpha / - delta_and_Rho / Rho kinase .
3140144	0	neurotensin	57,68	thyrotropin-releasing_hormone	16,45	neurotensin	thyrotropin-releasing hormone	299757(Tax:10116)	25569(Tax:10116)	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of thyrotropin-releasing_hormone -LRB- TRH -RRB- with neurotensin and dopamine in the central nucleus of the amygdala during stress ulcer formation in rats .
3148872	0	neurotensin	14,25	thyrotropin-releasing_hormone	44,73	neurotensin	thyrotropin-releasing hormone	100354423(Tax:9986)	100346454(Tax:9986)	Gene	Gene	Antagonism|nmod|START_ENTITY induced|nsubj|Antagonism induced|nmod|END_ENTITY	Antagonism of neurotensin induced miosis by thyrotropin-releasing_hormone -LRB- TRH -RRB- in rabbits .
11769329	0	neurotensin	63,74	tyrosine_hydroxylase	34,54	neurotensin	tyrosine hydroxylase	4922	7054	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the tyrosine_hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells .
11687289	0	neurotensin_receptor_2	6,28	Ntsr2	35,40	neurotensin receptor 2	Ntsr2	18217(Tax:10090)	18217(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mouse neurotensin_receptor_2 gene -LRB- Ntsr2 -RRB- : genomic organization , transcriptional regulation and genetic mapping on chromosome 12 .
8343996	0	neurotoxic_esterase	12,31	NTE	33,36	neurotoxic esterase	NTE	425396(Tax:9031)	425396(Tax:9031)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of neurotoxic_esterase -LRB- NTE -RRB- in the prevention and potentiation of organophosphorus-induced delayed neurotoxicity -LRB- OPIDN -RRB- .
12853419	0	neurotrophic_factor	49,68	CA1	103,106	neurotrophic factor	CA1	81737(Tax:10116)	310218(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|region region|compound|END_ENTITY	c-fos reduces corticosterone-mediated effects on neurotrophic_factor expression in the rat hippocampal CA1 region .
7703397	0	neurotrophic_factor	58,77	GDNF	45,49	neurotrophic factor	GDNF	81737(Tax:10116)	25453(Tax:10116)	Gene	Gene	Glial_cell_line-derived_neurotrophic_factor|dep|START_ENTITY Glial_cell_line-derived_neurotrophic_factor|appos|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor -LRB- GDNF -RRB- , a new neurotrophic_factor for motoneurones .
7790368	0	neurotrophic_factor	63,82	GDNF	51,55	neurotrophic factor	GDNF	9048	2668	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Peripheral expression and biological activities of GDNF , a new neurotrophic_factor for avian and mammalian peripheral neurons .
24936223	0	neurotrophic_factor	13,32	IFN-b	0,5	neurotrophic factor	IFN-b	4908	3456	Gene	Gene	expression|compound|START_ENTITY expression|nummod|END_ENTITY	IFN-b alters neurotrophic_factor expression in T cells isolated from multiple_sclerosis patients - implication of novel neurotensin/NTSR1 pathway in neuroprotection .
8387505	1	neurotrophic_factor	170,189	epidermal_growth_factor	238,261	neurotrophic factor	epidermal growth factor	81737(Tax:10116)	25313(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Distinct effects of the neurotrophic_factor , nerve_growth_factor , and the mitogenic factor , epidermal_growth_factor .
21536100	0	neurotrophic_factor	33,52	neuregulin-1	54,66	neurotrophic factor	neuregulin-1	4908	3084	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	In vitro production of an active neurotrophic_factor , neuregulin-1 : qualitative comparison of different cell-free translation systems .
16713586	0	neurotrophic_tyrosine_kinase_receptor_2	38,77	NTRK2	84,89	neurotrophic tyrosine kinase receptor 2	NTRK2	4915	4915	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of specific haplotypes of neurotrophic_tyrosine_kinase_receptor_2 gene -LRB- NTRK2 -RRB- with vulnerability to nicotine_dependence in African-Americans and European-Americans .
18347002	0	neurotrophic_tyrosine_kinase_receptor_3	19,58	NTRK3	60,65	neurotrophic tyrosine kinase receptor 3	NTRK3	4916	4916	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the neurotrophic_tyrosine_kinase_receptor_3 -LRB- NTRK3 -RRB- gene and childhood-onset mood_disorders .
16373086	0	neurotrophic_tyrosine_kinase_receptor_type_1	50,94	NTRK1	101,106	neurotrophic tyrosine kinase receptor type 1	NTRK1	4914	4914	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel frameshift and splice site mutations in the neurotrophic_tyrosine_kinase_receptor_type_1 gene -LRB- NTRK1 -RRB- associated with hereditary_sensory_neuropathy_type_IV .
18077166	0	neurotrophic_tyrosine_kinase_receptor_type_1	56,100	NTRK1	107,112	neurotrophic tyrosine kinase receptor type 1	NTRK1	4914	4914	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel missense , insertion and deletion mutations in the neurotrophic_tyrosine_kinase_receptor_type_1 gene -LRB- NTRK1 -RRB- associated with congenital insensitivity_to_pain with anhidrosis .
17918233	0	neurotrophic_tyrosine_kinase_receptor_type_2	23,67	NTRK2	69,74	neurotrophic tyrosine kinase receptor type 2	NTRK2	4915	4915	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Genetic association of neurotrophic_tyrosine_kinase_receptor_type_2 -LRB- NTRK2 -RRB- With Alzheimer 's _ disease .
26071584	0	neurotrophin	82,94	ADNP	104,108	neurotrophin	ADNP	627	23394	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Assessment of plasma brain-derived_neurotrophic_factor -LRB- BDNF -RRB- , activity-dependent neurotrophin protein -LRB- ADNP -RRB- and vasoactive intestinal peptide -LRB- VIP -RRB- concentrations in treatment-na ve humans with multiple_sclerosis .
19281964	0	neurotrophin	56,68	Brain-Derived_Neurotrophic_Factor	1,34	neurotrophin	Brain-Derived Neurotrophic Factor	627	627	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	-LSB- Brain-Derived_Neurotrophic_Factor -LRB- BDNF -RRB- : role of this neurotrophin in cardiovascular physiopathology -RSB- .
26531617	0	neurotrophin	30,42	Coronin-1	0,9	neurotrophin	Coronin-1	627	11151	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Coronin-1 mediates hierarchal neurotrophin signaling required for sympathetic neuron target innervation .
11553687	0	neurotrophin	59,71	TRK	55,58	neurotrophin	TRK	627	4914	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	The non-peptidyl fungal metabolite L-783 ,281 activates TRK neurotrophin receptors .
11399424	0	neurotrophin	28,40	Trk	0,3	neurotrophin	Trk	627	4914	Gene	Gene	action|compound|START_ENTITY mediators|nmod|action receptors|dep|mediators receptors|compound|END_ENTITY	Trk receptors : mediators of neurotrophin action .
11738045	0	neurotrophin	28,40	Trk	15,18	neurotrophin	Trk	627	4914	Gene	Gene	interactions|compound|START_ENTITY interactions|nmod|receptor receptor|compound|END_ENTITY	Specificity in Trk receptor : neurotrophin interactions : the crystal structure of TrkB-d5 in complex with neurotrophin-4 / 5 .
16701206	0	neurotrophin	26,38	Trk	22,25	neurotrophin	Trk	627	4914	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Cell survival through Trk neurotrophin receptors is differentially regulated by ubiquitination .
19759314	0	neurotrophin	76,88	Trk	20,23	neurotrophin	Trk	627	4914	Gene	Gene	responses|compound|START_ENTITY regulates|nmod|responses regulates|nsubj|Axonal Axonal|nmod|receptors receptors|compound|END_ENTITY	Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses .
20923662	0	neurotrophin	46,58	Trk	102,105	neurotrophin	Trk	627	4914	Gene	Gene	versatility|nmod|START_ENTITY Role|nmod|versatility N-terminal|nsubj|Role N-terminal|nmod|receptors receptors|compound|END_ENTITY	Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors .
8580709	0	neurotrophin	16,28	Trk	44,47	neurotrophin	Trk	627	4914	Gene	Gene	signalling|compound|START_ENTITY events|nmod|signalling events|nmod|END_ENTITY	Early events in neurotrophin signalling via Trk and p75 receptors .
8951673	0	neurotrophin	71,83	Trk	27,30	neurotrophin	Trk	627	4914	Gene	Gene	chimeras|compound|START_ENTITY using|dobj|chimeras specificities|xcomp|using specificities|nsubj|determinants determinants|nmod|receptor receptor|compound|END_ENTITY	Structural determinants of Trk receptor specificities using BDNF-based neurotrophin chimeras .
10366607	0	neurotrophin	28,40	TrkB	0,4	neurotrophin	TrkB	627	4915	Gene	Gene	specificities|compound|START_ENTITY isoforms|nmod|specificities isoforms|amod|END_ENTITY	TrkB isoforms with distinct neurotrophin specificities are expressed in predominantly nonoverlapping populations of avian dorsal root ganglion neurons .
10798407	0	neurotrophin	40,52	TrkB	133,137	neurotrophin	TrkB	627	4915	Gene	Gene	signaling|compound|START_ENTITY absence|nmod|signaling Cortical_degeneration|nmod|absence Cortical_degeneration|dep|retraction retraction|nmod|removal removal|nmod|END_ENTITY	Cortical_degeneration in the absence of neurotrophin signaling : dendritic retraction and neuronal_loss after removal of the receptor TrkB .
15507485	0	neurotrophin	82,94	TrkB	10,14	neurotrophin	TrkB	627	4915	Gene	Gene	receptor|compound|START_ENTITY involves|dobj|receptor involves|nsubj|outgrowth outgrowth|compound|END_ENTITY	Truncated TrkB receptor-induced outgrowth of dendritic_filopodia involves the p75 neurotrophin receptor .
8396171	0	neurotrophin	31,43	TrkB	26,30	neurotrophin	TrkB	627	4915	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus .
21346312	0	neurotrophin	134,146	neuropeptide_Y	26,40	neurotrophin	neuropeptide Y	627	4852	Gene	Gene	production|compound|START_ENTITY associated|nmod|production associated|nsubjpass|effect effect|nmod|END_ENTITY	Neuroprotective effect of neuropeptide_Y against b-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production .
8891268	0	neurotrophin	14,26	neuropeptide_Y	55,69	neurotrophin	neuropeptide Y	627	24604(Tax:10116)	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Comparison of neurotrophin regulation of human and rat neuropeptide_Y -LRB- NPY -RRB- neurons : induction of NPY production in aggregate cultures derived from rat but not from human fetal brains .
14699954	0	neurotrophin	8,20	p75	4,7	neurotrophin	p75	627	11168	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The p75 neurotrophin receptor : multiple interactors and numerous functions .
18171948	0	neurotrophin	4,16	p75	0,3	neurotrophin	p75	627	3560	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol_4 ,5 - bisphosphate .
18289033	0	neurotrophin	33,45	p75	29,32	neurotrophin	p75	627	7133	Gene	Gene	functions|compound|START_ENTITY functions|amod|END_ENTITY	Small molecule modulation of p75 neurotrophin receptor functions .
19067488	0	neurotrophin	105,117	p75	101,104	neurotrophin	p75	627	11168	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor .
19229990	0	neurotrophin	71,83	p75	67,70	neurotrophin	p75	627	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Nerve_growth_factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor .
19376068	0	neurotrophin	22,34	p75	18,21	neurotrophin	p75	627	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers .
23260665	0	neurotrophin	22,34	p75	57,60	neurotrophin	p75	627	7133	Gene	Gene	dissection|nmod|START_ENTITY dissection|acl|signaling signaling|nmod|receptor receptor|amod|END_ENTITY	Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor .
23260665	0	neurotrophin	61,73	p75	57,60	neurotrophin	p75	627	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor .
26109945	0	neurotrophin	8,20	p75	4,7	neurotrophin	p75	627	11168	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	The p75 neurotrophin receptor : at the crossroad of neural repair and death .
7943171	0	neurotrophin	22,34	p75	45,48	neurotrophin	p75	627	7133	Gene	Gene	Identification|nmod|START_ENTITY receptors|nsubj|Identification receptors|dobj|END_ENTITY	Identification of the neurotrophin receptors p75 and trk in a series of Wilms ' _ tumors .
8730779	0	neurotrophin	32,44	trk	18,21	neurotrophin	trk	627	4914	Gene	Gene	receptors|compound|START_ENTITY Expression|nmod|receptors Expression|nmod|family family|compound|END_ENTITY	Expression of the trk family of neurotrophin receptors in developing and adult dorsal root ganglion neurons .
18413248	0	neurotrophin-3	33,47	Arf6	62,66	neurotrophin-3	Arf6	4908	382	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	In vitro and in vivo analysis of neurotrophin-3 activation of Arf6 and Rac-1 .
8288635	0	neurotrophin-3	44,58	Brain-derived_neurotrophic_factor	0,33	neurotrophin-3	Brain-derived neurotrophic factor	81737(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor increases neurotrophin-3 expression in cerebellar granule neurons .
10737596	0	neurotrophin-3	92,106	CREB	17,21	neurotrophin-3	CREB	4908	1385	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Possible role of CREB in the stimulation of oligodendrocyte precursor cell proliferation by neurotrophin-3 .
10632603	0	neurotrophin-3	14,28	NT-3	83,87	neurotrophin-3	NT-3	428099(Tax:9031)	428099(Tax:9031)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of neurotrophin-3 -LRB- NT-3 -RRB- and anterograde axonal transport of endogenous NT-3 by retinal ganglion cells in chick embryos .
20178830	0	neurotrophin-3	15,29	NT-3	31,35	neurotrophin-3	NT-3	18205(Tax:10090)	18205(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of neurotrophin-3 -LRB- NT-3 -RRB- in the functional elimination of synaptic contacts during neuromuscular development .
8366347	0	neurotrophin-3	105,119	NT-3	121,125	neurotrophin-3	NT-3	81737(Tax:10116)	81737(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Cholinergic regulation of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and nerve_growth_factor -LRB- NGF -RRB- but not neurotrophin-3 -LRB- NT-3 -RRB- mRNA levels in the developing rat hippocampus .
8837968	0	neurotrophin-3	26,40	NT-3	42,46	neurotrophin-3	NT-3	4908	4908	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An association study of a neurotrophin-3 -LRB- NT-3 -RRB- gene polymorphism with schizophrenia .
10756065	0	neurotrophin-3	28,42	NT3	44,47	neurotrophin-3	NT3	18205(Tax:10090)	18205(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Cutaneous overexpression of neurotrophin-3 -LRB- NT3 -RRB- selectively restores sensory innervation in NT3 gene knockout mice .
22544632	0	neurotrophin-3	59,73	Phospholipase_D1	0,16	neurotrophin-3	Phospholipase D1	81737(Tax:10116)	25096(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Phospholipase_D1 is an important regulator of bFGF-induced neurotrophin-3 expression and neurite outgrowth in H19-7 cells .
17059557	0	neurotrophin-3	14,28	Sp3	51,54	neurotrophin-3	Sp3	4908	6670	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of neurotrophin-3 gene transcription by Sp3 and Sp4 in neurons .
9488719	0	neurotrophin-3	89,103	Trk	152,155	neurotrophin-3	Trk	4908	4914	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	High resolution mapping of the binding site of TrkA for nerve growth factor and TrkC for neurotrophin-3 on the second immunoglobulin-like domain of the Trk receptors .
11519486	0	neurotrophin-3	45,59	TrkC	70,74	neurotrophin-3	TrkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY expression|nmod|receptor expression|appos|END_ENTITY	Adenovirus vector-directed expression of the neurotrophin-3 receptor -LRB- TrkC -RRB- in mouse astrocytes .
17278135	0	neurotrophin-3	53,67	TrkC	16,20	neurotrophin-3	TrkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY Localization|nmod|signaling Localization|nmod|END_ENTITY	Localization of TrkC to Schwann cells and effects of neurotrophin-3 signaling at neuromuscular synapses .
9078261	0	neurotrophin-3	121,135	TrkC	98,102	neurotrophin-3	TrkC	81737(Tax:10116)	29613(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Analysis of mitogen-activated protein kinase activation by naturally occurring splice variants of TrkC , the receptor for neurotrophin-3 .
12900521	0	neurotrophin-3	74,88	brain-derived_neurotrophic_factor	39,72	neurotrophin-3	brain-derived neurotrophic factor	4908	627	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	The neurotrophins nerve growth factor , brain-derived_neurotrophic_factor , neurotrophin-3 , and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial_asthma .
12761941	0	neurotrophin-3	92,106	glial_cell_line-derived_neurotrophic_factor	34,77	neurotrophin-3	glial cell line-derived neurotrophic factor	100718910	100717276	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|effects effects|nmod|END_ENTITY	-LSB- Synergetic protective effects of glial_cell_line-derived_neurotrophic_factor combined with neurotrophin-3 in F-actin on hair cell after noise trauma -RSB- .
8163724	0	neurotrophin-3	51,65	nerve_growth_factor	91,110	neurotrophin-3	nerve growth factor	81737(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Embryonic sensory development : local expression of neurotrophin-3 and target expression of nerve_growth_factor .
7747601	0	neurotrophin-3	62,76	neurotrophin-4	38,52	neurotrophin-3	neurotrophin-4	81737(Tax:10116)	25730(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus .
16313513	0	neurotrophin-3	52,66	sphingosine_kinase_1	14,34	neurotrophin-3	sphingosine kinase 1	4908	8877	Gene	Gene	action|amod|START_ENTITY mediator|nmod|action END_ENTITY|nmod|mediator	Novel role of sphingosine_kinase_1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors .
1653651	0	neurotrophin-3	84,98	trkC	0,4	neurotrophin-3	trkC	4908	4916	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	trkC , a new member of the trk family of tyrosine protein kinases , is a receptor for neurotrophin-3 .
7529173	0	neurotrophin-3	24,38	trkC	56,60	neurotrophin-3	trkC	4908	4916	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin .
8093043	0	neurotrophin-3	73,87	trkC	14,18	neurotrophin-3	trkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of trkC in a mouse osteoblastic cell line and its response to neurotrophin-3 .
8223273	0	neurotrophin-3	21,35	trkC	0,4	neurotrophin-3	trkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	trkC , a receptor for neurotrophin-3 , is widely expressed in the developing nervous system and in non-neuronal tissues .
8344249	0	neurotrophin-3	22,36	trkC	0,4	neurotrophin-3	trkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY encodes|dobj|receptors encodes|nsubj|END_ENTITY	trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities .
8494648	0	neurotrophin-3	95,109	trkC	8,12	neurotrophin-3	trkC	81737(Tax:10116)	29613(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY exhibit|nmod|cells receptors|acl:relcl|exhibit encodes|dobj|receptors encodes|nsubj|locus locus|compound|END_ENTITY	The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells .
8621424	0	neurotrophin-3	11,25	trkC	127,131	neurotrophin-3	trkC	4908	4916	Gene	Gene	Binding|nmod|START_ENTITY mediated|nsubj|Binding mediated|nmod|epitope epitope|acl|recognized recognized|nmod|END_ENTITY	Binding of neurotrophin-3 to p75LNGFR , TrkA , and TrkB mediated by a single functional epitope distinct from that recognized by trkC .
9125498	0	neurotrophin-3	154,168	trkC	83,87	neurotrophin-3	trkC	81737(Tax:10116)	29613(Tax:10116)	Gene	Gene	analogs|amod|START_ENTITY changing|nmod|analogs determinants|advcl|changing determinants|nmod|neurotrophin-3 neurotrophin-3|nmod|agonists agonists|amod|END_ENTITY	Specificity determinants in neurotrophin-3 and design of nerve_growth_factor-based trkC agonists by changing central beta-strand bundle residues to their neurotrophin-3 analogs .
9125498	0	neurotrophin-3	28,42	trkC	83,87	neurotrophin-3	trkC	81737(Tax:10116)	29613(Tax:10116)	Gene	Gene	START_ENTITY|nmod|agonists agonists|amod|END_ENTITY	Specificity determinants in neurotrophin-3 and design of nerve_growth_factor-based trkC agonists by changing central beta-strand bundle residues to their neurotrophin-3 analogs .
9405689	0	neurotrophin-3	105,119	trkC	41,45	neurotrophin-3	trkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	suggests|nmod|START_ENTITY suggests|nsubj|deletion deletion|nmod|isoforms isoforms|nmod|gene gene|amod|END_ENTITY	Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis .
12905890	0	neurotrophin-4	15,29	NT-4	30,34	neurotrophin-4	NT-4	4909	4909	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of neurotrophin-4 -LRB- NT-4 -RRB- gene in baculovirus expression vector system -RSB- .
11074460	0	neurotrophin-4	75,89	Trk	95,98	neurotrophin-4	Trk	78405(Tax:10090)	18211(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Axonal outgrowth from adult mouse nodose ganglia in vitro is stimulated by neurotrophin-4 in a Trk receptor and mitogen-activated protein kinase-dependent way .
15297267	0	neurotrophin-4	74,88	cholecystokinin	55,70	neurotrophin-4	cholecystokinin	78405(Tax:10090)	12424(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice .
7747601	0	neurotrophin-4	38,52	neurotrophin-3	62,76	neurotrophin-4	neurotrophin-3	25730(Tax:10116)	81737(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Brain-derived_neurotrophic_factor and neurotrophin-4 increase neurotrophin-3 expression in the rat hippocampus .
16142215	0	neurotrophin_3	31,45	TrkC	65,69	neurotrophin 3	TrkC	18205(Tax:10090)	18213(Tax:10090)	Gene	Gene	START_ENTITY|acl|signalling signalling|nmod|END_ENTITY	Genetic evidence for selective neurotrophin_3 signalling through TrkC but not TrkB in vivo .
10069331	0	neurturin	120,129	GFR_alpha2	95,105	neurturin	GFR alpha2	18188(Tax:10090)	14586(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Retarded_growth and deficits_in_the_enteric_and_parasympathetic_nervous_system in mice lacking GFR_alpha2 , a functional neurturin receptor .
12433948	0	neurturin	11,20	GFR_alpha2	0,10	neurturin	GFR alpha2	18188(Tax:10090)	14586(Tax:10090)	Gene	Gene	signalling|compound|START_ENTITY regulates|nsubj|signalling END_ENTITY|parataxis|regulates	GFR_alpha2 / neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons .
10493748	0	neurturin	20,29	Ret	72,75	neurturin	Ret	428340(Tax:9031)	396107(Tax:9031)	Gene	Gene	actions|nmod|START_ENTITY correlate|nsubj|actions correlate|nmod|patterns patterns|nmod|expression expression|compound|END_ENTITY	Multiple actions of neurturin correlate with spatiotemporal patterns of Ret expression in developing chick cranial_ganglion_neurons .
9182803	0	neurturin	38,47	Ret	75,78	neurturin	Ret	4902	5979	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	TrnR2 , a novel receptor that mediates neurturin and GDNF signaling through Ret .
9192898	0	neurturin	65,74	Ret	41,44	neurturin	Ret	4902	5979	Gene	Gene	receptor|compound|START_ENTITY form|dobj|receptor interacts|xcomp|form interacts|nmod|END_ENTITY	A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor .
24798654	0	neutral_ceramidase	26,44	INS-1	60,65	neutral ceramidase	INS-1	114104(Tax:10116)	24505(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|cells cells|compound|END_ENTITY	Low-dose cytokine-induced neutral_ceramidase secretion from INS-1 cells via exosomes and its anti-apoptotic effect .
9638501	0	neutral_endopeptidase	13,34	BP102	46,51	neutral endopeptidase	BP102	24590(Tax:10116)	369072(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Effects of a neutral_endopeptidase inhibitor , BP102 , on the development of deoxycorticosterone_acetate-salt hypertension in kininogen-deficient Brown Norway Katholiek rats .
1396581	0	neutral_endopeptidase	36,57	CALLA	68,73	neutral endopeptidase	CALLA	4311	4311	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Jurkat T cells express a functional neutral_endopeptidase activity -LRB- CALLA -RRB- involved in T cell activation .
7775337	0	neutral_endopeptidase	8,29	IL-1_beta	88,97	neutral endopeptidase	IL-1 beta	24590(Tax:10116)	24494(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY induced|nsubj|Role induced|nmod|END_ENTITY	Role of neutral_endopeptidase in bronchial_hyperresponsiveness to bradykinin induced by IL-1_beta .
15963503	0	neutral_endopeptidase	14,35	NEP	37,40	neutral endopeptidase	NEP	4311	4311	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of neutral_endopeptidase -LRB- NEP -RRB- facilitates neurogenic_inflammation .
16597367	0	neutral_endopeptidase	13,34	NEP	36,39	neutral endopeptidase	NEP	4311	4311	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Induction of neutral_endopeptidase -LRB- NEP -RRB- activity of SK-N-SH cells by natural compounds from green tea .
8575569	0	neutral_endopeptidase	16,37	NEP	39,42	neutral endopeptidase	NEP	4311	4311	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of neutral_endopeptidase -LRB- NEP -RRB- mRNA in human bronchi .
8687431	0	neutral_endopeptidase	62,83	Proadrenomedullin_N-terminal_20_peptide	0,39	neutral endopeptidase	Proadrenomedullin N-terminal 20 peptide	4311	133	Gene	Gene	cleaved|nmod|START_ENTITY cleaved|nsubjpass|END_ENTITY	Proadrenomedullin_N-terminal_20_peptide is rapidly cleaved by neutral_endopeptidase .
10371365	0	neutral_endopeptidase	75,96	angiotensin-converting_enzyme	45,74	neutral endopeptidase	angiotensin-converting enzyme	4311	1636	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	Sustained antihypertensive actions of a dual angiotensin-converting_enzyme neutral_endopeptidase inhibitor , sampatrilat , in black hypertensive subjects .
15286094	0	neutral_endopeptidase	82,103	angiotensin-converting_enzyme	52,81	neutral endopeptidase	angiotensin-converting enzyme	4311	1636	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	Pharmacokinetics of M100240 and MDL 100,173 , a dual angiotensin-converting_enzyme / neutral_endopeptidase inhibitor , in healthy young and elderly volunteers .
8558518	2	neutral_endopeptidase	157,178	angiotensin-converting_enzyme	127,156	neutral endopeptidase	angiotensin-converting enzyme	4311	1636	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Incorporation of bicyclic and substituted monocyclic_azepinones as dipeptide surrogates in angiotensin-converting_enzyme / neutral_endopeptidase inhibitors .
22627111	0	neutral_sphingomyelinase	81,105	Endothelin-1	0,12	neutral sphingomyelinase	Endothelin-1	83537(Tax:10116)	24323(Tax:10116)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral_sphingomyelinase .
11129654	0	neutral_sphingomyelinase	101,125	L-selectin	47,57	neutral sphingomyelinase	L-selectin	6610	6402	Gene	Gene	generation|nmod|START_ENTITY shed|nmod|generation shed|dobj|END_ENTITY	Streptolysin_O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral_sphingomyelinase .
9716456	0	neutral_sphingomyelinase	26,50	L-selectin	0,10	neutral sphingomyelinase	L-selectin	6610	6402	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	L-selectin stimulates the neutral_sphingomyelinase and induces release of ceramide .
10187863	1	neutral_sphingomyelinase	89,113	caspase-3	118,127	neutral sphingomyelinase	caspase-3	6610	836	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of magnesium-dependent neutral_sphingomyelinase via caspase-3 .
16033420	0	neutral_sphingomyelinase	79,103	iNOS	66,70	neutral sphingomyelinase	iNOS	6610	4843	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|END_ENTITY	Amyloid-beta peptide enhances tumor_necrosis_factor-alpha-induced iNOS through neutral_sphingomyelinase / ceramide pathway in oligodendrocytes .
17085432	0	neutral_sphingomyelinase-2	9,35	vascular_cell_adhesion_molecule-1	92,125	neutral sphingomyelinase-2	vascular cell adhesion molecule-1	55512	7412	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Role for neutral_sphingomyelinase-2 in tumor_necrosis_factor_alpha-stimulated expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM -RRB- in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 .
1899427	0	neutrophil-activating_peptide-1	23,54	interleukin-8	55,68	neutrophil-activating peptide-1	interleukin-8	3576	3576	Gene	Gene	production|nmod|START_ENTITY production|dep|END_ENTITY	Enhanced production of neutrophil-activating_peptide-1 / interleukin-8 in rheumatoid_arthritis .
1438244	0	neutrophil-activating_peptide_2	48,79	interleukin_8	83,96	neutrophil-activating peptide 2	interleukin 8	5473	3576	Gene	Gene	START_ENTITY|nmod|receptors receptors|amod|END_ENTITY	High - and low-affinity binding of GRO_alpha and neutrophil-activating_peptide_2 to interleukin_8 receptors on human neutrophils .
1505106	0	neutrophil_activating_peptide-1	14,45	IL-8	53,57	neutrophil activating peptide-1	IL-8	3576	3576	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of neutrophil_activating_peptide-1 -LRB- NAP-1 / IL-8 -RRB- by blood and synovial fluid mononuclear cells from patients with arthritis .
2156928	0	neutrophil_chemotactic_factor	38,67	IL-8	68,72	neutrophil chemotactic factor	IL-8	4689	3576	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Cytokine-induced gene expression of a neutrophil_chemotactic_factor / IL-8 in human hepatocytes .
18190883	0	neutrophil_gelatinase-B_associated_lipocalin	18,62	Lipocalin-2	70,81	neutrophil gelatinase-B associated lipocalin	Lipocalin-2	3934	3934	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The novel role of neutrophil_gelatinase-B_associated_lipocalin -LRB- NGAL -RRB- / Lipocalin-2 as a biomarker for lupus_nephritis .
21741997	0	neutrophil_gelatinase-associated_lipocalin	20,62	C/EBP	0,5	neutrophil gelatinase-associated lipocalin	C/EBP	3934	1050	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	C/EBP targets to neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- as a repressor for metastasis of MDA-MB-231 cells .
23162623	0	neutrophil_gelatinase-associated_lipocalin	14,56	C/EBPb	71,77	neutrophil gelatinase-associated lipocalin	C/EBPb	3934	1051	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of neutrophil_gelatinase-associated_lipocalin expression by C/EBPb in lung_carcinoma cells .
24048788	0	neutrophil_gelatinase-associated_lipocalin	57,99	Epidermal_growth_factor	0,23	neutrophil gelatinase-associated lipocalin	Epidermal growth factor	3934	1950	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Epidermal_growth_factor down-regulates the expression of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- through E-cadherin in pancreatic_cancer cells .
19951994	0	neutrophil_gelatinase-associated_lipocalin	16,58	ErbB2	62,67	neutrophil gelatinase-associated lipocalin	ErbB2	3934	2064	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of neutrophil_gelatinase-associated_lipocalin by ErbB2 through nuclear factor-kappaB activation .
12600287	0	neutrophil_gelatinase-associated_lipocalin	90,132	NGAL	134,138	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Cloning and identification of 5 ' - untranslated region -LRB- UTR -RRB- and 3 ' - untranslated region of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- gene from esophageal_carcinoma cell line SHEEC -RSB- .
20406131	0	neutrophil_gelatinase-associated_lipocalin	31,73	NGAL	75,79	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Clinical implication of plasma neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- concentrations in patients with advanced carotid_atherosclerosis .
21421891	0	neutrophil_gelatinase-associated_lipocalin	37,79	NGAL	81,85	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intra-amniotic infection upregulates neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- expression at the maternal-fetal interface at term : implications for infection-related preterm_birth .
23114405	0	neutrophil_gelatinase-associated_lipocalin	46,88	NGAL	90,94	neutrophil gelatinase-associated lipocalin	NGAL	170496(Tax:10116)	170496(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Increased trophoblastic apoptosis mediated by neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- activation in the nitrofen model of congenital_diaphragmatic_hernia .
23439619	0	neutrophil_gelatinase-associated_lipocalin	22,64	NGAL	66,70	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Circulating levels of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- correlate with the presence and severity of preeclampsia .
23627612	0	neutrophil_gelatinase-associated_lipocalin	22,64	NGAL	66,70	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of plasma neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- with sepsis and acute kidney_dysfunction .
23760084	0	neutrophil_gelatinase-associated_lipocalin	14,56	NGAL	124,128	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|END_ENTITY	Evaluation of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- , matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and their complex MMP-9 / NGAL in sera and urine of patients with kidney_tumors .
24550181	0	neutrophil_gelatinase-associated_lipocalin	25,67	NGAL	135,139	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	levels|nmod|START_ENTITY levels|dep|END_ENTITY	Maternal serum levels of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- , matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- and their complex MMP-9 / NGAL in pregnancies with preeclampsia and those with a small for gestational age neonate : a longitudinal study .
24697112	0	neutrophil_gelatinase-associated_lipocalin	12,54	NGAL	56,60	neutrophil gelatinase-associated lipocalin	NGAL	3934	3934	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- in cerebrospinal fluids for screening of acute bacterial_meningitis .
27087673	0	neutrophil_gelatinase-associated_lipocalin	14,56	NGAL	58,62	neutrophil gelatinase-associated lipocalin	NGAL	170496(Tax:10116)	170496(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of neutrophil_gelatinase-associated_lipocalin -LRB- NGAL -RRB- in peripheral nerve repair .
16061852	0	neutrophil_gelatinase-associated_lipocalin	31,73	matrix_metalloproteinase-9	4,30	neutrophil gelatinase-associated lipocalin	matrix metalloproteinase-9	3934	4318	Gene	Gene	complex|amod|START_ENTITY complex|dep|END_ENTITY	The matrix_metalloproteinase-9 / neutrophil_gelatinase-associated_lipocalin complex plays a role in breast_tumor growth and is present in the urine of breast_cancer patients .
22962218	0	neutrophil_gelatinase_associated_lipocalin	31,73	NGAL	75,79	neutrophil gelatinase associated lipocalin	NGAL	3934	3934	Gene	Gene	Variation|nmod|START_ENTITY Variation|appos|END_ENTITY	Variation of serum and urinary neutrophil_gelatinase_associated_lipocalin -LRB- NGAL -RRB- after strenuous physical exercise .
24395189	0	neutrophil_gelatinase_associated_lipocalin	17,59	NGAL	61,65	neutrophil gelatinase associated lipocalin	NGAL	3934	3934	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum and plasma neutrophil_gelatinase_associated_lipocalin -LRB- NGAL -RRB- levels are not equivalent in patients admitted to intensive care .
25778333	0	neutrophil_gelatinase_associated_lipocalin	40,82	NGAL	84,88	neutrophil gelatinase associated lipocalin	NGAL	3934	3934	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The effect of anaesthetic management on neutrophil_gelatinase_associated_lipocalin -LRB- NGAL -RRB- levels after robotic surgical oncology .
17021000	0	nf-kappaB	174,183	nuclear_factor-kappaB	151,172	nf-kappaB	nuclear factor-kappaB	4790	4790	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Isodeoxyelephantopin , a novel sesquiterpene_lactone , potentiates apoptosis , inhibits invasion , and abolishes osteoclastogenesis through suppression of nuclear_factor-kappaB -LRB- nf-kappaB -RRB- activation and nf-kappaB-regulated gene expression .
25406993	0	nhr-176	0,7	cyp-35d1	18,26	nhr-176	cyp-35d1	184496(Tax:6239)	184495(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	nhr-176 regulates cyp-35d1 to control hydroxylation-dependent metabolism of thiabendazole in C. _ elegans .
24567339	0	nicalin	9,16	NRA-2	0,5	nicalin	NRA-2	172803(Tax:6239)	172803(Tax:6239)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	NRA-2 , a nicalin homolog , regulates neuronal_death by controlling surface localization of toxic Caenorhabditis_elegans DEG/ENaC channels .
15189355	0	nicastrin	9,18	APH-1	30,35	nicastrin	APH-1	23385	51107	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin : identification of nicastrin mutants that selectively interact with APH-1 .
12054507	0	nicastrin	21,30	BACE1	0,5	nicastrin	BACE1	23385	23621	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BACE1 interacts with nicastrin .
11784090	0	nicastrin	6,15	LIN-12	29,35	nicastrin	LIN-12	172905(Tax:6239)	176282(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY functions|nmod|END_ENTITY	APH-2 / nicastrin functions in LIN-12 / Notch signaling in the Caenorhabditis_elegans somatic gonad .
11784090	0	nicastrin	6,15	Notch	36,41	nicastrin	Notch	172905(Tax:6239)	176282(Tax:6239)	Gene	Gene	functions|compound|START_ENTITY END_ENTITY|dep|functions	APH-2 / nicastrin functions in LIN-12 / Notch signaling in the Caenorhabditis_elegans somatic gonad .
12392556	0	nicolin_1	55,64	NICN1	71,76	nicolin 1	NICN1	84276	84276	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of the mammalian-specific nicolin_1 gene -LRB- NICN1 -RRB- encoding a nuclear 24 kDa protein .
17922140	0	nicotinamide_N-methyltransferase	33,65	Stat3	0,5	nicotinamide N-methyltransferase	Stat3	4837	6774	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stat3 up-regulates expression of nicotinamide_N-methyltransferase in human cancer cells .
24389478	0	nicotinamide_phosphoribosyl_transferase	21,60	NAMPT	62,67	nicotinamide phosphoribosyl transferase	NAMPT	10135	10135	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of a novel nicotinamide_phosphoribosyl_transferase -LRB- NAMPT -RRB- inhibitor via in silico screening .
22570471	0	nicotinamide_phosphoribosyltransferase	14,52	NAMPT	54,59	nicotinamide phosphoribosyltransferase	NAMPT	10135	10135	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of nicotinamide_phosphoribosyltransferase -LRB- NAMPT -RRB- activity by small molecule GMX1778 regulates reactive oxygen species -LRB- ROS -RRB- - mediated cytotoxicity in a p53 - and nicotinic_acid phosphoribosyltransferase1 -LRB- NAPRT1 -RRB- - dependent manner .
25709099	0	nicotinamide_phosphoribosyltransferase	14,52	NAMPT	54,59	nicotinamide phosphoribosyltransferase	NAMPT	10135	10135	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of nicotinamide_phosphoribosyltransferase -LRB- NAMPT -RRB- as a therapeutic strategy in cancer .
23859118	0	nicotinamide_phosphoribosyltransferase	52,90	nampt	92,97	nicotinamide phosphoribosyltransferase	nampt	59027(Tax:10090)	59027(Tax:10090)	Gene	Gene	discovery|nmod|START_ENTITY discovery|appos|END_ENTITY	Structure-based discovery of novel amide-containing nicotinamide_phosphoribosyltransferase -LRB- nampt -RRB- inhibitors .
26675378	0	nicotinate_phosphoribosyltransferase	24,60	NAPRT	62,67	nicotinate phosphoribosyltransferase	NAPRT	93100	93100	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Extensive regulation of nicotinate_phosphoribosyltransferase -LRB- NAPRT -RRB- expression in human tissues and tumors .
15929983	0	nicotinic_acetylcholine_receptor	65,97	Beta2	0,5	nicotinic acetylcholine receptor	Beta2	1137	10242	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic_acetylcholine_receptor .
23637165	0	nicotinic_acetylcholine_receptor	34,66	Chrna2	81,87	nicotinic acetylcholine receptor	Chrna2	11441(Tax:10090)	110902(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Targeted deletion of the mouse a2 nicotinic_acetylcholine_receptor subunit gene -LRB- Chrna2 -RRB- potentiates nicotine-modulated behaviors .
24607864	0	nicotinic_acetylcholine_receptor	72,104	nAChR	106,111	nicotinic acetylcholine receptor	nAChR	1137	1137	Gene	Gene	subunits|compound|START_ENTITY subunits|compound|END_ENTITY	Cigarette smoking during pregnancy regulates the expression of specific nicotinic_acetylcholine_receptor -LRB- nAChR -RRB- subunits in the human placenta .
10605940	0	nicotinic_acetylcholine_receptor	65,97	nerve_growth_factor	11,30	nicotinic acetylcholine receptor	nerve growth factor	170945(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effects of nerve_growth_factor and nicotine on the expression of nicotinic_acetylcholine_receptor subunits in PC12 cells .
22209457	0	nicotinic_acid_receptor	79,102	NAR	104,107	nicotinic acid receptor	NAR	353250(Tax:10116)	353250(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	SAR studies of C2_ethers of 2H-pyrano -LSB- 2,3-d -RSB- pyrimidine-2 ,4,7 -LRB- 1H ,3 H -RRB- - triones as nicotinic_acid_receptor -LRB- NAR -RRB- agonist .
12480912	0	nidogen-1	93,102	entactin-1	82,92	nidogen-1	entactin-1	18073(Tax:10090)	18073(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|/ /|amod|END_ENTITY	Neurologic_defects and selective disruption of basement membranes in mice lacking entactin-1 / nidogen-1 .
25957482	0	nidogen-1	26,35	meprin_b	51,59	nidogen-1	meprin b	18073(Tax:10090)	17288(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Basement membrane protein nidogen-1 is a target of meprin_b in cisplatin nephrotoxicity .
12215539	0	nidogen-2	52,61	nidogen-2	68,77	nidogen-2	nidogen-2	18074(Tax:10090)	18074(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Gene structure and functional analysis of the mouse nidogen-2 gene : nidogen-2 is not essential for basement membrane formation in mice .
12215539	0	nidogen-2	68,77	nidogen-2	52,61	nidogen-2	nidogen-2	18074(Tax:10090)	18074(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Gene structure and functional analysis of the mouse nidogen-2 gene : nidogen-2 is not essential for basement membrane formation in mice .
3040524	0	ninaE	32,37	opsin	38,43	ninaE	opsin	42367(Tax:7227)	42367(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Analysis of the promoter of the ninaE opsin gene in Drosophila_melanogaster .
11004522	0	ninein	46,52	glycogen_synthase_kinase_3beta	85,115	ninein	glycogen synthase kinase 3beta	51199	2932	Gene	Gene	protein|compound|START_ENTITY protein|acl:relcl|interacts interacts|nmod|END_ENTITY	Cloning and characterization of a novel human ninein protein that interacts with the glycogen_synthase_kinase_3beta .
23572524	0	nischarin	25,34	liver_kinase_B1	67,82	nischarin	liver kinase B1	11188	6794	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Integrin-binding protein nischarin interacts with tumor suppressor liver_kinase_B1 -LRB- LKB1 -RRB- to regulate cell migration of breast epithelial cells .
21436382	0	nitrate_reductase	67,84	B55	23,26	nitrate reductase	B55	844112(Tax:3702)	842360(Tax:3702)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Protein phosphatase_2A B55 and A regulatory subunits interact with nitrate_reductase and are essential for nitrate_reductase activation .
21454300	0	nitrate_reductase	73,90	NIA1	97,101	nitrate reductase	NIA1	844112(Tax:3702)	844112(Tax:3702)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The regulatory region controlling the nitrate-responsive expression of a nitrate_reductase gene , NIA1 , in Arabidopsis .
26252500	0	nitrate_reductase	15,32	THB1	0,4	nitrate reductase	THB1	5722285(Tax:3055)	5724558(Tax:3055)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	THB1 regulates nitrate_reductase activity and THB1 and THB2 transcription differentially respond to NO and the nitrate/ammonium balance in Chlamydomonas .
22128174	0	nitric-oxide_synthase	55,76	Hsp90	105,110	nitric-oxide synthase	Hsp90	4842	3320	Gene	Gene	cleft|nmod|START_ENTITY Modulation|nmod|cleft regulates|nsubj|Modulation regulates|dobj|binding binding|nmod|proteins proteins|amod|END_ENTITY	Modulation of heme/substrate binding cleft of neuronal nitric-oxide_synthase -LRB- nNOS -RRB- regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination .
12857749	0	nitric-oxide_synthase	28,49	Interleukin-10	0,14	nitric-oxide synthase	Interleukin-10	4846	3586	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Interleukin-10 induction of nitric-oxide_synthase expression attenuates CD40-mediated interleukin-12 synthesis in human endothelial cells .
11526108	0	nitric-oxide_synthase	15,36	dNOS	43,47	nitric-oxide synthase	dNOS	34495(Tax:7227)	34495(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Drosophila nitric-oxide_synthase gene -LRB- dNOS -RRB- encodes a family of proteins that can modulate NOS activity by acting as dominant negative regulators .
15155759	0	nitric-oxide_synthase	63,84	hsp90	12,17	nitric-oxide synthase	hsp90	4842	3320	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide_synthase .
7510678	0	nitric-oxide_synthase	14,35	interferon-gamma	55,71	nitric-oxide synthase	interferon-gamma	18125(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of nitric-oxide_synthase mRNA expression by interferon-gamma and picolinic_acid .
16963620	0	nitric-oxide_synthase-2	27,50	C-Rel	18,23	nitric-oxide synthase-2	C-Rel	4843	5966	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Essential role of C-Rel in nitric-oxide_synthase-2 transcriptional activation : time-dependent control by salicylate .
20299462	0	nitric-oxide_synthase_3	100,123	NOS3	125,129	nitric-oxide synthase 3	NOS3	4846	4846	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Angiotensin_II stimulates thick ascending limb NO production via AT -LRB- 2 -RRB- receptors and Akt1-dependent nitric-oxide_synthase_3 -LRB- NOS3 -RRB- activation .
12726922	0	nitric_oxide_synthase	119,140	GTP-cyclohydrolase_I	84,104	nitric oxide synthase	GTP-cyclohydrolase I	4843	2643	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	Hydrogen_peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase_I and increases nitric_oxide_synthase activity in vascular endothelial cells .
11166745	0	nitric_oxide_synthase	10,31	NOS	33,36	nitric oxide synthase	NOS	4843	4843	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Placental nitric_oxide_synthase -LRB- NOS -RRB- activity and nitric_oxide -LRB- NO -RRB- production in normal pregnancy , pre-eclampsia and eclampsia .
24755185	0	nitric_oxide_synthase	22,43	NOS	45,48	nitric oxide synthase	NOS	4842	4842	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of nitric_oxide_synthase -LRB- NOS -RRB- isoforms in ovarian follicles of the catfish , Clarias batrachus and its relation with ovarian activity .
25680459	0	nitric_oxide_synthase	17,38	NOS	40,43	nitric oxide synthase	NOS	4843	4843	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Flavone inhibits nitric_oxide_synthase -LRB- NOS -RRB- activity , nitric_oxide production and protein S-nitrosylation in breast_cancer cells .
8525486	0	nitric_oxide_synthase	44,65	NOS	67,70	nitric oxide synthase	NOS	4843	4843	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of methylmercury -LRB- CH3HgCl -RRB- injury on nitric_oxide_synthase -LRB- NOS -RRB- activity in cultured human umbilical vascular endothelial cells .
10581471	0	nitric_oxide_synthase	34,55	NOS-1	57,62	nitric oxide synthase	NOS-1	4842	4842	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cellular localization of neuronal nitric_oxide_synthase -LRB- NOS-1 -RRB- in the human and rat retina .
10966937	0	nitric_oxide_synthase	17,38	NOS1	40,44	nitric oxide synthase	NOS1	24598(Tax:10116)	24598(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of neuronal nitric_oxide_synthase -LRB- NOS1 -RRB- in the pathogenesis of renal hemodynamic changes in diabetes .
10593859	0	nitric_oxide_synthase	49,70	NOS2	72,76	nitric oxide synthase	NOS2	4843	4843	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of the expression of the inflammatory nitric_oxide_synthase -LRB- NOS2 -RRB- by cyclic_AMP .
19859740	0	nitric_oxide_synthase	27,48	NOS2	57,61	nitric oxide synthase	NOS2	4843	4843	Gene	Gene	promoter|compound|START_ENTITY promoter|compound|END_ENTITY	Malaria severity and human nitric_oxide_synthase type 2 -LRB- NOS2 -RRB- promoter haplotypes .
8577713	0	nitric_oxide_synthase	46,67	NOS2	69,73	nitric oxide synthase	NOS2	4843	4843	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of human inducible nitric_oxide_synthase -LRB- NOS2 -RRB- gene by cytokines : initial analysis of the human NOS2 promoter .
25956856	0	nitric_oxide_synthase	71,92	NOS3	94,98	nitric oxide synthase	NOS3	4846	4846	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Functional G894T -LRB- rs1799983 -RRB- polymorphism and intron-4 VNTR variant of nitric_oxide_synthase -LRB- NOS3 -RRB- gene are susceptibility biomarkers of obesity among Tunisians .
9270610	0	nitric_oxide_synthase	59,80	NOS3	82,86	nitric oxide synthase	NOS3	4846	4846	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Migraine association and linkage studies of an endothelial nitric_oxide_synthase -LRB- NOS3 -RRB- gene polymorphism .
12209856	0	nitric_oxide_synthase	52,73	TRPC6	0,5	nitric oxide synthase	TRPC6	100135576(Tax:10141)	100135637(Tax:10141)	Gene	Gene	colocalized|nmod|START_ENTITY colocalized|nsubjpass|END_ENTITY	TRPC6 immunoreactivity is colocalized with neuronal nitric_oxide_synthase in extrinsic fibers innervating guinea_pig intrinsic cardiac_ganglia .
11145282	0	nitric_oxide_synthase	74,95	endothelin-converting_enzyme-1	8,38	nitric oxide synthase	endothelin-converting enzyme-1	24599(Tax:10116)	94204(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Role Role|nmod|END_ENTITY	Role of endothelin-converting_enzyme-1 in the suppression of constitutive nitric_oxide_synthase in rat gastric_mucosal_injury by indomethacin .
12389206	0	nitric_oxide_synthase	85,106	estrogen_receptor_alpha	9,32	nitric oxide synthase	estrogen receptor alpha	18125(Tax:10090)	13982(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY Roles|nmod|regulation Roles|nmod|END_ENTITY	Roles of estrogen_receptor_alpha and androgen_receptor in the regulation of neuronal nitric_oxide_synthase .
10719359	0	nitric_oxide_synthase-2	14,37	NOS-2	39,44	nitric oxide synthase-2	NOS-2	4843	4843	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of nitric_oxide_synthase-2 -LRB- NOS-2 -RRB- in reactive astrocytes of the human glaucomatous_optic_nerve head .
21559562	0	nm23	67,71	Nm23	0,4	nm23	Nm23	4830	4830	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|amod|END_ENTITY	Nm23 expression in human gastric_cancers - possible correlation of nm23 with lymph-node metastasis .
14558955	0	nm23	15,19	PCNA	60,64	nm23	PCNA	4830	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of nm23 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in human brain_gliomas and their significance -RSB- .
17642161	0	nm23	14,18	TIMP-2	27,33	nm23	TIMP-2	4830	7077	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of nm23 , MMP-2 , TIMP-2 in breast_neoplasm in Zhengzhou Center Hospital , China .
12839671	0	nm23	50,54	c-erbB-2	19,27	nm23	c-erbB-2	4830	2064	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	-LSB- Overexpression of c-erbB-2 and hypoexpression of nm23 relating to poor prognosis of colorectal_carcinoma -RSB- .
1988104	0	nm23	33,37	nm23-H2	44,51	nm23	nm23-H2	4830	4831	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a second human nm23 gene , nm23-H2 .
11326661	0	nm23	45,49	p53	40,43	nm23	p53	4830	7157	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	Immunohistochemical examinations -LRB- Ki67 , p53 , nm23 -RRB- and DNA cytophotometry in bladder_cancer .
8217603	0	nm23-2	18,24	NDP_kinase_alpha	25,41	nm23-2	NDP kinase alpha	83782(Tax:10116)	191575(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Expression of the nm23-2 / NDP_kinase_alpha gene in rat mammary and oral_carcinoma cells of varying metastatic potential .
26816534	0	nm23-H1	68,75	FOXO3	23,28	nm23-H1	FOXO3	4830	2309	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcriptional factor FOXO3 negatively regulates the expression of nm23-H1 in non-small_cell_lung_cancer .
7542225	0	nm23-H1	5,12	NDPK-A	13,19	nm23-H1	NDPK-A	4830	4830	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	High nm23-H1 / NDPK-A expression in Ewing_tumors : paradoxical immunohistochemical reactivity and lack of prognostic significance .
15280446	0	nm23-H1	32,39	Nucleoside_diphosphate_kinase_A	0,31	nm23-H1	Nucleoside diphosphate kinase A	4830	4830	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Nucleoside_diphosphate_kinase_A / nm23-H1 promotes metastasis of NB69-derived human neuroblastoma .
17167724	0	nm23-H1	16,23	beta-Catenin	48,60	nm23-H1	beta-Catenin	4830	1499	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transfection of nm23-H1 increased expression of beta-Catenin , E-Cadherin and TIMP-1 and decreased the expression of MMP-2 , CD44v6_and_VEGF and inhibited the metastatic potential of human non-small_cell_lung_cancer cell line L9981 .
8102131	0	nm23-H1	22,29	nm23-H2	42,49	nm23-H1	nm23-H2	4830	4831	Gene	Gene	START_ENTITY|dep|not not|nmod|END_ENTITY	Reduced expression of nm23-H1 , but not of nm23-H2 , is concordant with the frequency of lymph-node metastasis of human breast_cancer .
19026164	0	nm23-H1	19,26	p53	137,140	nm23-H1	p53	4830	7157	Gene	Gene	cells|amod|START_ENTITY Over-expression|nmod|cells provides|nsubj|Over-expression provides|advcl|oxidative oxidative|xcomp|due due|advcl|raising raising|dobj|END_ENTITY	Over-expression of nm23-H1 in HeLa cells provides cells with higher resistance to oxidative stress possibly due to raising intracellular p53 and GPX1 .
11919189	0	nm23-H2	119,126	Integrin_cytoplasmic_domain-associated_protein_1alpha	0,53	nm23-H2	Integrin cytoplasmic domain-associated protein 1alpha	4831	9270	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Integrin_cytoplasmic_domain-associated_protein_1alpha -LRB- ICAP-1alpha -RRB- interacts directly with the metastasis suppressor nm23-H2 , and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement .
1988104	0	nm23-H2	44,51	nm23	33,37	nm23-H2	nm23	4831	4830	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Identification of a second human nm23 gene , nm23-H2 .
8102131	0	nm23-H2	42,49	nm23-H1	22,29	nm23-H2	nm23-H1	4831	4830	Gene	Gene	not|nmod|START_ENTITY END_ENTITY|dep|not	Reduced expression of nm23-H1 , but not of nm23-H2 , is concordant with the frequency of lymph-node metastasis of human breast_cancer .
8778301	0	no-on-transient_A	116,133	nonA	135,139	no-on-transient A	nonA	32603(Tax:7227)	32603(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Defects in courtship_and_vision caused by amino_acid substitutions in a putative RNA-binding protein encoded by the no-on-transient_A -LRB- nonA -RRB- gene of Drosophila .
18596967	0	nob2	44,48	Cacna1f	36,43	nob2	Cacna1f	54652(Tax:10090)	54652(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Modified Ca -LRB- v -RRB- 1.4 expression in the Cacna1f -LRB- nob2 -RRB- mouse due to alternative splicing of an ETn inserted in exon 2 .
17430614	0	nob4	66,70	Grm6	83,87	nob4	Grm6	108072(Tax:10090)	108072(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Generation , identification and functional characterization of the nob4 mutation of Grm6 in the mouse .
17910740	0	nociceptin	43,53	OPRL1	64,69	nociceptin	OPRL1	5368	4987	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Association analysis of genes encoding the nociceptin receptor -LRB- OPRL1 -RRB- and its endogenous ligand -LRB- PNOC -RRB- with alcohol or illicit drug dependence .
10498840	0	nociceptin	21,31	ORL1	103,107	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	Phe1psi|dep|START_ENTITY Phe1psi|dep|activation activation|nmod|rectifier rectifier|nmod|agonist agonist|nmod|receptors receptors|nummod|END_ENTITY	-LSB- Phe1psi -LRB- CH2-NH -RRB- Gly2 -RSB- nociceptin - -LRB- 1 - 13 -RRB- - NH2 activation of an inward rectifier as a partial agonist of ORL1 receptors in rat periaqueductal gray .
10692489	0	nociceptin	31,41	ORL1	194,198	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|compound|START_ENTITY inactivation|nmod|receptor inactivation|dep|evidence evidence|nmod|study study|nmod|domain domain|compound|END_ENTITY	Functional inactivation of the nociceptin receptor by alanine_substitution_of_glutamine_286 at the C terminus of transmembrane segment VI : evidence from a site-directed mutagenesis study of the ORL1 receptor transmembrane-binding domain .
10810242	0	nociceptin	40,50	ORL1	61,65	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Pharmacological characterization of the nociceptin receptor , ORL1 .
10814826	0	nociceptin	47,57	ORL1	67,71	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	An alternatively spliced transcript of the rat nociceptin receptor ORL1 gene encodes a truncated receptor .
10998522	0	nociceptin	4,14	ORL1	16,20	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The nociceptin -LRB- ORL1 -RRB- receptor : molecular cloning and functional architecture .
10998550	0	nociceptin	56,66	ORL1	77,81	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Species differences in the efficacy of compounds at the nociceptin receptor -LRB- ORL1 -RRB- .
11689089	0	nociceptin	30,40	ORL1	52,56	nociceptin	ORL1	5368	4987	Gene	Gene	analogues|compound|START_ENTITY studies|nmod|analogues studies|dep|receptor receptor|amod|END_ENTITY	Structure-activity studies on nociceptin analogues : ORL1 receptor binding and biological activity of cyclic_disulfide-containing analogues of nociceptin peptides .
14550303	0	nociceptin	54,64	ORL1	66,70	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Identification of a hexapeptide binding region in the nociceptin -LRB- ORL1 -RRB- receptor by photo-affinity labelling with Ac-Arg-Bpa-Tyr-Arg-Trp-Arg-NH2 .
15707012	0	nociceptin	80,90	ORL1	58,62	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin -RSB- .
16321540	0	nociceptin	40,50	ORL1	0,4	nociceptin	ORL1	5368	4987	Gene	Gene	preferences|nmod|START_ENTITY preferences|amod|END_ENTITY	ORL1 and opioid receptor preferences of nociceptin and dynorphin_A analogues with Dmp substituted for N-terminal aromatic residues .
18068993	0	nociceptin	49,59	ORL1	44,48	nociceptin	ORL1	5368	4987	Gene	Gene	START_ENTITY|nsubj|modification modification|nmod|agonist agonist|nmod|END_ENTITY	Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist .
19577933	0	nociceptin	101,111	ORL1	115,119	nociceptin	ORL1	5368	4987	Gene	Gene	-RSB-|dobj|START_ENTITY -RSB-|nmod|receptor receptor|nummod|END_ENTITY	Discriminatory synergistic effect of Trp-substitutions in superagonist -LSB- -LRB- Arg/Lys -RRB- -LRB- 14 -RRB- , -LRB- Arg/Lys -RRB- -LRB- 15 -RRB- -RSB- nociceptin on ORL1 receptor binding and activation .
19879767	0	nociceptin	53,63	ORL1	93,97	nociceptin	ORL1	5368	4987	Gene	Gene	-RSB-|dobj|START_ENTITY -RSB-|nmod|induction induction|nmod|activation activation|compound|END_ENTITY	Spare interactions of highly potent -LSB- Arg -LRB- 14 -RRB- , Lys -LRB- 15 -RRB- -RSB- nociceptin for cooperative induction of ORL1 receptor activation .
22061823	0	nociceptin	99,109	ORL1	94,98	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor .
25284251	0	nociceptin	78,88	ORL1	73,77	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor .
8732266	0	nociceptin	62,72	ORL1	16,20	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Increase by the ORL1 receptor -LRB- opioid receptor-like1 -RRB- ligand , nociceptin , of inwardly rectifying K conductance in dorsal raphe nucleus neurones .
8798582	0	nociceptin	79,89	ORL1	45,49	nociceptin	ORL1	5368	4987	Gene	Gene	modification|nmod|START_ENTITY END_ENTITY|nmod|modification	Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin , a naturally occurring nociceptive peptide .
8994054	0	nociceptin	36,46	ORL1	15,19	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	ligand|dobj|START_ENTITY ligand|nsubj|Actions Actions|nmod|receptor receptor|compound|END_ENTITY	Actions of the ORL1 receptor ligand nociceptin on membrane properties of rat periaqueductal gray neurons in vitro .
9086468	0	nociceptin	38,48	ORL1	76,80	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|agonist agonist|appos|END_ENTITY	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by unilateral constriction_injury_to_the_sciatic_nerve in the rat .
9134994	0	nociceptin	38,48	ORL1	76,80	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|agonist agonist|appos|END_ENTITY	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by carageenan injection into the rat paw .
9607332	0	nociceptin	88,98	ORL1	25,29	nociceptin	ORL1	5368	4987	Gene	Gene	A|compound|START_ENTITY recognition|nmod|A involved|nmod|recognition involved|nsubjpass|domains domains|nmod|END_ENTITY	Different domains of the ORL1 and kappa-opioid receptors are involved in recognition of nociceptin and dynorphin A .
9669489	0	nociceptin	21,31	ORL1	76,80	nociceptin	ORL1	5368	4987	Gene	Gene	Phe1psi|dep|START_ENTITY agonist|nsubj|Phe1psi agonist|nmod|receptor receptor|appos|END_ENTITY	-LSB- Phe1psi -LRB- CH2-NH -RRB- Gly2 -RSB- nociceptin - -LRB- 1-13 -RRB- - NH2 is an agonist of the nociceptin -LRB- ORL1 -RRB- receptor .
9669489	0	nociceptin	64,74	ORL1	76,80	nociceptin	ORL1	5368	4987	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- Phe1psi -LRB- CH2-NH -RRB- Gly2 -RSB- nociceptin - -LRB- 1-13 -RRB- - NH2 is an agonist of the nociceptin -LRB- ORL1 -RRB- receptor .
9726656	0	nociceptin	14,24	ORL1	55,59	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|endogenous endogenous|acl|ligand ligand|nmod|receptor receptor|compound|END_ENTITY	The effect of nociceptin , an endogenous ligand for the ORL1 receptor , on rat colonic contraction and transit .
9879729	0	nociceptin	37,47	ORL1	0,4	nociceptin	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	receptor-mediated|nmod|START_ENTITY receptor-mediated|nsubj|END_ENTITY	ORL1 receptor-mediated inhibition by nociceptin of noradrenaline release from perivascular sympathetic nerve endings of the rat tail artery .
9920456	0	nociceptin	12,22	Orphanin_FQ	0,11	nociceptin	Orphanin FQ	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	modulates|nsubj|START_ENTITY END_ENTITY|parataxis|modulates	Orphanin_FQ / nociceptin modulates glutamate - and kainic_acid-induced currents in acutely isolated rat spinal dorsal horn neurons .
14550927	0	nociceptin	11,21	nociceptin	39,49	nociceptin	nociceptin	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nociceptin and analogues of nociceptin upon spontaneous dorsal root activity recorded from an in vitro preparation of rat spinal cord .
14550927	0	nociceptin	39,49	nociceptin	11,21	nociceptin	nociceptin	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of nociceptin and analogues of nociceptin upon spontaneous dorsal root activity recorded from an in vitro preparation of rat spinal cord .
9086468	0	nociceptin	38,48	opioid_receptor-like1	53,74	nociceptin	opioid receptor-like1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by unilateral constriction_injury_to_the_sciatic_nerve in the rat .
9134994	0	nociceptin	38,48	opioid_receptor-like1	53,74	nociceptin	opioid receptor-like1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by carageenan injection into the rat paw .
9300417	0	nociceptin	47,57	opioid_receptor-like1	62,83	nociceptin	opioid receptor-like1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	START_ENTITY|appos|agonist agonist|amod|END_ENTITY	Analgesic effect of intrathecally administered nociceptin , an opioid_receptor-like1 receptor agonist , in the rat formalin test .
14757141	0	nociceptin	32,42	orphanin_FQ	20,31	nociceptin	orphanin FQ	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	inhibition|dep|START_ENTITY inhibition|nmod|END_ENTITY	Tonic inhibition by orphanin_FQ / nociceptin of noradrenaline neurotransmission in the amygdala .
24155687	0	nociceptin	24,34	orphanin_FQ	12,23	nociceptin	orphanin FQ	5368	5368	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The role of orphanin_FQ / nociceptin in neuroplasticity : relationship to stress , anxiety and neuroinflammation .
9455999	0	nociceptin	12,22	orphanin_FQ	24,35	nociceptin	orphanin FQ	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Presence of nociceptin -LRB- orphanin_FQ -RRB- receptors in rat retina : comparison with receptors in striatum .
15571866	0	nociceptin_receptor	164,183	NOP	185,188	nociceptin receptor	NOP	4987	4987	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	A new synthetic approach of N - -LRB- 4-amino-2-methylquinolin-6-yl -RRB- -2 - -LRB- 4-ethylphenoxymethyl -RRB- benzamide -LRB- JTC-801 -RRB- and its analogues and their pharmacological evaluation as nociceptin_receptor -LRB- NOP -RRB- antagonists .
12370297	0	nocturnin	24,33	CREB	66,70	nocturnin	CREB	378568(Tax:8355)	379764(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY transcription|nsubj|regulation transcription|nmod|END_ENTITY	Circadian regulation of nocturnin transcription by phosphorylated CREB in Xenopus retinal photoreceptor cells .
15252029	0	noggin	16,22	FGF18	0,5	noggin	FGF18	9241	8817	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	FGF18 represses noggin expression and is induced by calcineurin .
8752214	0	noggin	29,35	bone_morphogenetic_protein_4	58,86	noggin	bone morphogenetic protein 4	9241	652	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The Spemann organizer signal noggin binds and inactivates bone_morphogenetic_protein_4 .
9671580	0	noi	128,131	Pax8	97,101	noi	Pax8	60636(Tax:7955)	60637(Tax:7955)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Characterization of three novel members of the zebrafish Pax2/5/8 family : dependency of Pax5 and Pax8 expression on the Pax2 .1 -LRB- noi -RRB- function .
11071286	0	non-ATPase_subunit_1	65,85	Rpn1	37,41	non-ATPase subunit 1	Rpn1	856422(Tax:4932)	856422(Tax:4932)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Cloning and functional expression of Rpn1 , a regulatory-particle non-ATPase_subunit_1 , of proteasome from Trypanosoma_cruzi .
20523037	0	non-muscle_Myosin_heavy_chain_9	4,35	MYH9	42,46	non-muscle Myosin heavy chain 9	MYH9	4627	4627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The non-muscle_Myosin_heavy_chain_9 gene -LRB- MYH9 -RRB- is not associated with lupus_nephritis in African_Americans .
19177153	0	non-muscle_myosin_heavy_chain_9	21,52	MYH9	59,63	non-muscle myosin heavy chain 9	MYH9	4627	4627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the non-muscle_myosin_heavy_chain_9 gene -LRB- MYH9 -RRB- are strongly associated with end-stage_renal_disease historically attributed to hypertension in African Americans .
23776349	0	non-muscle_myosin_heavy_chain_9	62,93	MYH9	95,99	non-muscle myosin heavy chain 9	MYH9	4627	4627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pilot study of an association between a common variant in the non-muscle_myosin_heavy_chain_9 -LRB- MYH9 -RRB- gene and type 2 diabetic_nephropathy in a Taiwanese population .
7488641	0	non-specific_lipid_transfer_protein	44,79	sterol_carrier_protein-2	81,105	non-specific lipid transfer protein	sterol carrier protein-2	25541(Tax:10116)	25541(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	The immunohistochemical localization of the non-specific_lipid_transfer_protein -LRB- sterol_carrier_protein-2 -RRB- in rat small intestine enterocytes .
2968951	0	non-specific_suppressor_factor	100,130	NSF	132,135	non-specific suppressor factor	NSF	4905	4905	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Non-specific regulatory mechanism of contact sensitivity : the requirement of intermediate cells for non-specific_suppressor_factor -LRB- NSF -RRB- activity .
8778301	0	nonA	135,139	no-on-transient_A	116,133	nonA	no-on-transient A	32603(Tax:7227)	32603(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Defects in courtship_and_vision caused by amino_acid substitutions in a putative RNA-binding protein encoded by the no-on-transient_A -LRB- nonA -RRB- gene of Drosophila .
12053071	0	nonmuscle_myosin_heavy_chain_B	14,44	SMemb	46,51	nonmuscle myosin heavy chain B	SMemb	79433(Tax:10116)	79433(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of nonmuscle_myosin_heavy_chain_B -LRB- SMemb -RRB- in rat allogeneic kidney transplantation .
6991029	0	nonspecific_cross-reacting_antigen	17,51	NCA	12,15	nonspecific cross-reacting antigen	NCA	1084	1084	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of NCA -LRB- nonspecific_cross-reacting_antigen -RRB- in the cells of the human granulocyte series .
3337731	0	nonspecific_crossreacting_antigen	21,54	carcinoembryonic_antigen	74,98	nonspecific crossreacting antigen	carcinoembryonic antigen	1084	1084	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Primary structure of nonspecific_crossreacting_antigen -LRB- NCA -RRB- , a member of carcinoembryonic_antigen -LRB- CEA -RRB- gene family , deduced from cDNA sequence .
2628429	0	nonspecific_lipid_transfer_protein	16,50	sterol_carrier_protein_2	52,76	nonspecific lipid transfer protein	sterol carrier protein 2	25541(Tax:10116)	25541(Tax:10116)	Gene	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|appos|END_ENTITY	Biosynthesis of nonspecific_lipid_transfer_protein -LRB- sterol_carrier_protein_2 -RRB- on free polyribosomes as a larger precursor in rat liver .
18264720	0	nonsteroidal_anti-inflammatory_drug-activated_gene-1	14,66	NAG-1	68,73	nonsteroidal anti-inflammatory drug-activated gene-1	NAG-1	9518	9518	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of nonsteroidal_anti-inflammatory_drug-activated_gene-1 -LRB- NAG-1 -RRB- inversely correlates with tumor progression in gastric_adenomas and carcinomas .
22871651	0	nonstructural_protein_5	25,48	NSP5	50,54	nonstructural protein 5	NSP5	92521	92521	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phylogenetic analysis of nonstructural_protein_5 -LRB- NSP5 -RRB- gene sequences in porcine rotavirus B strains .
22026649	0	norepinephrine_transporter	61,87	Akt	92,95	norepinephrine transporter	Akt	83511(Tax:10116)	24185(Tax:10116)	Gene	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	Angiotensin - -LRB- 1-7 -RRB- through Mas receptor up-regulates neuronal norepinephrine_transporter via Akt and Erk1/2-dependent pathways .
16005303	0	norepinephrine_transporter	35,61	Endothelin-1	0,12	norepinephrine transporter	Endothelin-1	83511(Tax:10116)	24323(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Endothelin-1 inhibits the neuronal norepinephrine_transporter in hearts of male rats .
21569456	0	norepinephrine_transporter	33,59	NET	66,69	norepinephrine transporter	NET	6530	6530	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The 1287_G / A polymorphism of the norepinephrine_transporter gene -LRB- NET -RRB- is involved in commission errors in Korean children with attention_deficit_hyperactivity_disorder .
25724484	0	norepinephrine_transporter	15,41	NET	43,46	norepinephrine transporter	NET	6530	6530	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of norepinephrine_transporter -LRB- NET , SLC6A2 -RRB- genotype with ADHD-related phenotypes : Findings of a longitudinal study from birth to adolescence .
12805287	0	norepinephrine_transporter	24,50	SLC6A2	57,63	norepinephrine transporter	SLC6A2	6530	6530	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A mutation in the human norepinephrine_transporter gene -LRB- SLC6A2 -RRB- associated with orthostatic_intolerance disrupts surface expression of mutant and wild-type transporters .
23185385	0	norepinephrine_transporter	49,75	SLC6A2	82,88	norepinephrine transporter	SLC6A2	6530	6530	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Comprehensive phenotype/genotype analyses of the norepinephrine_transporter gene -LRB- SLC6A2 -RRB- in ADHD : relation to maternal smoking during pregnancy .
24381062	0	norepinephrine_transporter	22,48	SLC6A2	55,61	norepinephrine transporter	SLC6A2	6530	6530	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No association of the norepinephrine_transporter gene -LRB- SLC6A2 -RRB- and cognitive and behavioural phenotypes of patients with autism_spectrum_disorder .
23979140	0	norepinephrine_transporter	10,36	neurokinin-1_receptor	58,79	norepinephrine transporter	neurokinin-1 receptor	6530	6869	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Regulated norepinephrine_transporter interaction with the neurokinin-1_receptor establishes transporter subcellular localization .
18429609	0	norepinephrine_transporter	79,105	serotonin_transporter	19,40	norepinephrine transporter	serotonin transporter	6530	6532	Gene	Gene	talopram|compound|START_ENTITY citalopram|nmod|talopram citalopram|compound|END_ENTITY	From the selective serotonin_transporter inhibitor citalopram to the selective norepinephrine_transporter inhibitor talopram : synthesis and structure-activity relationship studies .
21129446	0	norepinephrine_transporter	23,49	serotonin_transporter	59,80	norepinephrine transporter	serotonin transporter	20538(Tax:10090)	15567(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A greater role for the norepinephrine_transporter than the serotonin_transporter in murine nociception .
17032905	0	norepinephrine_transporter	92,118	syntaxin_1A	159,170	norepinephrine transporter	syntaxin 1A	6530	6804	Gene	Gene	expression|compound|START_ENTITY expression|acl|linked linked|nmod|changes changes|nmod|complexes complexes|amod|END_ENTITY	Amphetamine induces a calcium/calmodulin-dependent _ protein_kinase_II-dependent reduction in norepinephrine_transporter surface expression linked to changes in syntaxin_1A / transporter complexes .
17188889	0	norepinephrine_transporter	44,70	syntaxin_1A	76,87	norepinephrine transporter	syntaxin 1A	6530	6804	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Calcium-dependent interactions of the human norepinephrine_transporter with syntaxin_1A .
24684754	0	notch	68,73	HES1	54,58	notch	HES1	31293(Tax:7227)	3280	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Prostate_tumor_OVerexpressed-1 -LRB- PTOV1 -RRB- down-regulates HES1 and HEY1 notch targets genes and promotes prostate_cancer progression .
2402639	0	notch	41,46	Xotch	0,5	notch	Xotch	31293(Tax:7227)	394367(Tax:8355)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Xotch , the Xenopus homolog of Drosophila notch .
10357943	0	notch	58,63	her1	0,4	notch	her1	31293(Tax:7227)	30287(Tax:7955)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	her1 , a zebrafish pair-rule like gene , acts downstream of notch signalling to control somite development .
21743299	0	notch1	21,27	MicroRNA-34a	0,12	notch1	MicroRNA-34a	4851	407040	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme .
22199353	0	notch1	19,25	fe65	63,67	notch1	fe65	4851	322	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Dual regulation of notch1 signaling pathway by adaptor protein fe65 .
20628156	0	notch1	14,20	nrf2	34,38	notch1	nrf2	18128(Tax:10090)	18024(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of notch1 signaling by nrf2 : implications for tissue regeneration .
23587900	0	notch2	0,6	notch4	8,14	notch2	notch4	4853	4855	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|amod|END_ENTITY	notch2 , notch4 gene polymorphisms in psoriasis_vulgaris .
23587900	0	notch4	8,14	notch2	0,6	notch4	notch2	4855	4853	Gene	Gene	polymorphisms|amod|START_ENTITY END_ENTITY|appos|polymorphisms	notch2 , notch4 gene polymorphisms in psoriasis_vulgaris .
10366748	0	notch_1	52,59	presenilin_1	27,39	notch 1	presenilin 1	4851	5663	Gene	Gene	facilitates|dobj|START_ENTITY facilitates|nsubj|END_ENTITY	The Alzheimer-related gene presenilin_1 facilitates notch_1 in primary mammalian neurons .
23297191	0	notum	56,61	Follistatin	0,11	notum	Follistatin	147111	10468	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	Follistatin antagonizes activin signaling and acts with notum to direct planarian head regeneration .
15606508	0	novel_nuclear_protein-1	27,50	NNP-1	20,25	novel nuclear protein-1	NNP-1	8568	8568	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Upregulation of the NNP-1 -LRB- novel_nuclear_protein-1 , D21S2056E -RRB- gene in keloid tissue determined by cDNA microarray and in situ hybridization .
15477006	0	nox1	26,30	p22phox	36,43	nox1	p22phox	27035	1535	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Functional association of nox1 with p22phox in vascular smooth muscle cells .
20628156	0	nrf2	34,38	notch1	14,20	nrf2	notch1	18024(Tax:10090)	18128(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of notch1 signaling by nrf2 : implications for tissue regeneration .
24388965	0	nsP4	25,29	HSP-90	45,51	nsP4	HSP-90	400668	3320	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Chikungunya_virus nsP3 _ nsP4 interacts with HSP-90 to promote virus replication : HSP-90 inhibitors reduce CHIKV_infection and inflammation in vivo .
24388965	0	nsP4	25,29	HSP-90	82,88	nsP4	HSP-90	400668	3320	Gene	Gene	interacts|nsubj|START_ENTITY interacts|ccomp|reduce reduce|nsubj|inhibitors inhibitors|compound|END_ENTITY	Chikungunya_virus nsP3 _ nsP4 interacts with HSP-90 to promote virus replication : HSP-90 inhibitors reduce CHIKV_infection and inflammation in vivo .
17490571	0	nuclear_factor-KappaB	64,85	granulocyte-macrophage_colony_stimulating_factor	12,60	nuclear factor-KappaB	granulocyte-macrophage colony stimulating factor	18033(Tax:10090)	12981(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	-LSB- Effects of granulocyte-macrophage_colony_stimulating_factor on nuclear_factor-KappaB activation in multiple organs of hemorrhage-induced acute_lung_injury in mice -RSB- .
11463954	0	nuclear_factor-erythroid_2	28,54	Interleukin-4	0,13	nuclear factor-erythroid 2	Interleukin-4	4778	3565	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Interleukin-4 downregulates nuclear_factor-erythroid_2 -LRB- NF-E2 -RRB- expression in primary megakaryocytes and in megakaryoblastic cell lines .
11463954	0	nuclear_factor-erythroid_2	28,54	NF-E2	56,61	nuclear factor-erythroid 2	NF-E2	4778	4778	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-4 downregulates nuclear_factor-erythroid_2 -LRB- NF-E2 -RRB- expression in primary megakaryocytes and in megakaryoblastic cell lines .
19799917	0	nuclear_factor-erythroid_2-related_factor-2	21,64	Nrf2	66,70	nuclear factor-erythroid 2-related factor-2	Nrf2	4780	4780	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A protective role of nuclear_factor-erythroid_2-related_factor-2 -LRB- Nrf2 -RRB- in inflammatory disorders .
21494319	0	nuclear_factor-kB	62,79	Tumor_necrosis_factor-a	0,23	nuclear factor-kB	Tumor necrosis factor-a	81736(Tax:10116)	24835(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Tumor_necrosis_factor-a induces transcriptional activation of nuclear_factor-kB in insulin-producing b-cells .
20652730	0	nuclear_factor-kB_essential_modulator	33,70	NEMO	72,76	nuclear factor-kB essential modulator	NEMO	8517	8517	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel missense mutation in the nuclear_factor-kB_essential_modulator -LRB- NEMO -RRB- gene resulting in impaired activation of the NF-kB pathway and a unique clinical phenotype presenting as MRSA subdural_empyema .
10208867	0	nuclear_factor-kappaB	66,87	Angiotensin_II	0,14	nuclear factor-kappaB	Angiotensin II	4790	183	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Angiotensin_II activates the proinflammatory transcription factor nuclear_factor-kappaB in human monocytes .
11108147	0	nuclear_factor-kappaB	85,106	Angiotensin_II	0,14	nuclear factor-kappaB	Angiotensin II	4790	183	Gene	Gene	factor|amod|START_ENTITY effects|nmod|factor induces|nmod|effects induces|nsubj|END_ENTITY	Angiotensin_II induces gene transcription through cell-type-dependent effects on the nuclear_factor-kappaB -LRB- NF-kappaB -RRB- transcription factor .
16293568	0	nuclear_factor-kappaB	68,89	Angiotensin_II	0,14	nuclear factor-kappaB	Angiotensin II	4790	183	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates endothelial integrin_beta3 expression via nuclear_factor-kappaB activation .
10501190	0	nuclear_factor-kappaB	80,101	Bradykinin	0,10	nuclear factor-kappaB	Bradykinin	4790	3827	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear_factor-kappaB .
15698590	0	nuclear_factor-kappaB	85,106	C-reactive_protein	148,166	nuclear factor-kappaB	C-reactive protein	4790	1401	Gene	Gene	START_ENTITY|nmod|cells cells|acl|stimulated stimulated|nmod|END_ENTITY	Fluvastatin inhibits the expression of tumor_necrosis_factor-alpha and activation of nuclear_factor-kappaB in human endothelial cells stimulated by C-reactive_protein .
16230390	0	nuclear_factor-kappaB	48,69	Cyclin_D1	0,9	nuclear factor-kappaB	Cyclin D1	4790	595	Gene	Gene	pathway|amod|START_ENTITY responsible|nsubj|pathway induction|parataxis|responsible induction|amod|END_ENTITY	Cyclin_D1 induction through IkappaB_kinase_beta / nuclear_factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes .
15211107	0	nuclear_factor-kappaB	53,74	Glial_cell_line-derived_neurotrophic_factor	0,43	nuclear factor-kappaB	Glial cell line-derived neurotrophic factor	4790	2668	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor enhances nuclear_factor-kappaB activity and invasive potential in human pancreatic_cancer cells .
11532196	0	nuclear_factor-kappaB	83,104	ICAM-1	128,134	nuclear factor-kappaB	ICAM-1	4790	3383	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Different effects of antisense RelA p65 and NF-kappaB1 p50 oligonucleotides on the nuclear_factor-kappaB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells .
18245554	0	nuclear_factor-kappaB	83,104	IkappaB_kinase_subunit_2	14,38	nuclear factor-kappaB	IkappaB kinase subunit 2	4790	3551	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Inhibition of IkappaB_kinase_subunit_2 in cutaneous_T-cell_lymphoma down-regulates nuclear_factor-kappaB constitutive activation , induces cell death , and potentiates the apoptotic response to antineoplastic chemotherapeutic agents .
11108147	0	nuclear_factor-kappaB	85,106	NF-kappaB	108,117	nuclear factor-kappaB	NF-kappaB	4790	4790	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Angiotensin_II induces gene transcription through cell-type-dependent effects on the nuclear_factor-kappaB -LRB- NF-kappaB -RRB- transcription factor .
11322928	0	nuclear_factor-kappaB	14,35	NF-kappaB	37,46	nuclear factor-kappaB	NF-kappaB	4790	4790	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Alteration of nuclear_factor-kappaB -LRB- NF-kappaB -RRB- expression in bone marrow stromal cells treated with etoposide .
16850495	0	nuclear_factor-kappaB	16,37	NF-kappaB	39,48	nuclear factor-kappaB	NF-kappaB	4790	4790	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of nuclear_factor-kappaB -LRB- NF-kappaB -RRB- is related to the grade of cervical_intraepithelial_neoplasia , but is not an independent predictor of high-risk human_papillomavirus or disease outcome in cervical_cancer .
18365680	0	nuclear_factor-kappaB	98,119	NF-kappaB	121,130	nuclear factor-kappaB	NF-kappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Synthesis of chroman-2-carboxylic_acid_N - -LRB- substituted -RRB- phenylamides and their inhibitory effect on nuclear_factor-kappaB -LRB- NF-kappaB -RRB- activation .
20068038	0	nuclear_factor-kappaB	163,184	NF-kappaB	186,195	nuclear factor-kappaB	NF-kappaB	4790	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic_acid-mediated optimal IkappaB_kinase_beta -LRB- IKKbeta -RRB- / nuclear_factor-kappaB -LRB- NF-kappaB -RRB- activation .
20415419	0	nuclear_factor-kappaB	134,155	NF-kappaB	157,166	nuclear factor-kappaB	NF-kappaB	4790	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	5-Hydroxytrytophan inhibits tert-butylhydroperoxide -LRB- t-BHP -RRB- - induced oxidative damage via the suppression of reactive species -LRB- RS -RRB- and nuclear_factor-kappaB -LRB- NF-kappaB -RRB- activation on human fibroblast .
20446732	0	nuclear_factor-kappaB	71,92	NF-kappaB	94,103	nuclear factor-kappaB	NF-kappaB	4790	4790	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Enterodiol and enterolactone modulate the immune response by acting on nuclear_factor-kappaB -LRB- NF-kappaB -RRB- signaling .
15743683	0	nuclear_factor-kappaB	14,35	NFkappaB	37,45	nuclear factor-kappaB	NFkappaB	4790	4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of nuclear_factor-kappaB -LRB- NFkappaB -RRB- identifies a high-risk subset of hormone-dependent breast_cancers .
18588981	0	nuclear_factor-kappaB	75,96	Nrf2	0,4	nuclear factor-kappaB	Nrf2	4790	4780	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear_factor-kappaB .
20079164	0	nuclear_factor-kappaB	64,85	Sox9	23,27	nuclear factor-kappaB	Sox9	4790	6662	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear_factor-kappaB in the cultured human intervertebral disc cells .
14761478	0	nuclear_factor-kappaB	52,73	THP-1	77,82	nuclear factor-kappaB	THP-1	4790	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	-LSB- The effect of silicon_dioxide on the activation of nuclear_factor-kappaB in THP-1 cells -RSB- .
11044363	0	nuclear_factor-kappaB	35,56	TNF-alpha	163,172	nuclear factor-kappaB	TNF-alpha	4790	7124	Gene	Gene	START_ENTITY|nmod|death death|amod|END_ENTITY	Inhibition of transcription factor nuclear_factor-kappaB by a mutant inhibitor-kappaBalpha attenuates resistance of human head_and_neck_squamous_cell_carcinoma to TNF-alpha caspase-mediated cell death .
11978627	0	nuclear_factor-kappaB	133,154	TNF-alpha	169,178	nuclear factor-kappaB	TNF-alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes : nuclear_factor-kappaB activation by TNF-alpha is obligatory .
12213594	0	nuclear_factor-kappaB	61,82	TNF-alpha	42,51	nuclear factor-kappaB	TNF-alpha	4790	7124	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Reduction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- related nuclear_factor-kappaB -LRB- NF-kappaB -RRB- translocation but not inhibitor kappa-B -LRB- Ikappa-B -RRB- - degradation by Rho protein inhibition in human endothelial cells .
11055977	0	nuclear_factor-kappaB	54,75	angiotensin_II	87,101	nuclear factor-kappaB	angiotensin II	4790	183	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Hyperinsulinemia enhances transcriptional activity of nuclear_factor-kappaB induced by angiotensin_II , hyperglycemia , and advanced glycosylation end products in vascular smooth muscle cells .
16352190	0	nuclear_factor-kappaB	14,35	c-reactive_protein	73,91	nuclear factor-kappaB	c-reactive protein	4790	1401	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of nuclear_factor-kappaB and correlation with elevated plasma c-reactive_protein in patients with unstable_angina .
17149750	0	nuclear_factor-kappaB	75,96	cyclin_D1	97,106	nuclear factor-kappaB	cyclin D1	4790	595	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Id1 induces the proliferation of cochlear sensory epithelial cells via the nuclear_factor-kappaB / cyclin_D1 pathway in vitro .
16001969	0	nuclear_factor-kappaB	131,152	cyclooxygenase-2	70,86	nuclear factor-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	mechanism|amod|START_ENTITY induces|nmod|mechanism induces|dobj|expression expression|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear_factor-kappaB and activating protein-1 mediated mechanism .
16204946	0	nuclear_factor-kappaB	134,155	cyclooxygenase-2	82,98	nuclear factor-kappaB	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY suppression|nmod|activation chiisanoside|nmod|suppression END_ENTITY|nmod|chiisanoside	Inhibition of lipopolysaccharide-induced expression of inducible nitric_oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear_factor-kappaB activation in RAW 264.7 macrophage cells .
16682957	0	nuclear_factor-kappaB	80,101	cyclooxygenase-2	30,46	nuclear factor-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|activation activation|nmod|p53 p53|amod|END_ENTITY	Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear_factor-kappaB .
17434257	0	nuclear_factor-kappaB	74,95	cyclooxygenase-2	38,54	nuclear factor-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	responses|amod|START_ENTITY induces|nmod|responses induces|dobj|expression expression|amod|END_ENTITY	Vasoactive intestinal peptide induces cyclooxygenase-2 expression through nuclear_factor-kappaB in human prostate cell lines Differential time-dependent responses in cancer progression .
9679714	0	nuclear_factor-kappaB	48,69	cyclooxygenase-2	13,29	nuclear factor-kappaB	cyclooxygenase-2	4790	5743	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 and activation of nuclear_factor-kappaB in myocardium of patients with congestive_heart_failure .
16293568	0	nuclear_factor-kappaB	68,89	integrin_beta3	38,52	nuclear factor-kappaB	integrin beta3	4790	3690	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Angiotensin_II stimulates endothelial integrin_beta3 expression via nuclear_factor-kappaB activation .
10501190	0	nuclear_factor-kappaB	80,101	interleukin-6	19,32	nuclear factor-kappaB	interleukin-6	4790	3569	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Bradykinin induces interleukin-6 expression in astrocytes through activation of nuclear_factor-kappaB .
20185670	0	nuclear_factor-kappaB	64,85	interleukin-8	87,100	nuclear factor-kappaB	interleukin-8	4790	3576	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Ketamine inhibits transcription factors activator_protein_1 and nuclear_factor-kappaB , interleukin-8 production , as well as CD11b and CD16 expression : studies in human leukocytes and leukocytic cell lines .
20185670	0	nuclear_factor-kappaB	64,85	interleukin-8	87,100	nuclear factor-kappaB	interleukin-8	4790	3576	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Ketamine inhibits transcription factors activator_protein_1 and nuclear_factor-kappaB , interleukin-8 production , as well as CD11b and CD16 expression : studies in human leukocytes and leukocytic cell lines .
17021000	0	nuclear_factor-kappaB	151,172	nf-kappaB	174,183	nuclear factor-kappaB	nf-kappaB	4790	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Isodeoxyelephantopin , a novel sesquiterpene_lactone , potentiates apoptosis , inhibits invasion , and abolishes osteoclastogenesis through suppression of nuclear_factor-kappaB -LRB- nf-kappaB -RRB- activation and nf-kappaB-regulated gene expression .
11532196	0	nuclear_factor-kappaB	83,104	p65	36,39	nuclear factor-kappaB	p65	4790	5970	Gene	Gene	expression|amod|START_ENTITY oligonucleotides|nmod|expression oligonucleotides|nsubj|effects effects|nmod|p50 p50|amod|END_ENTITY	Different effects of antisense RelA p65 and NF-kappaB1 p50 oligonucleotides on the nuclear_factor-kappaB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells .
12213593	0	nuclear_factor-kappaB	50,71	p65	72,75	nuclear factor-kappaB	p65	4790	5970	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Regulation of the transcriptional activity of the nuclear_factor-kappaB p65 subunit .
15210855	0	nuclear_factor-kappaB	19,40	p65	4,7	nuclear factor-kappaB	p65	4790	5970	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The p65 subunit of nuclear_factor-kappaB is a molecular target for radiation sensitization of human squamous_carcinoma cells .
17638900	0	nuclear_factor-kappaB	14,35	p65	109,112	nuclear factor-kappaB	p65	4790	5970	Gene	Gene	activity|amod|START_ENTITY Inhibition|nmod|activity involves|nsubj|Inhibition involves|dobj|O6-methylguanine O6-methylguanine|acl|induced induced|dobj|inhibition inhibition|nmod|DNA DNA|amod|END_ENTITY	Inhibition of nuclear_factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding .
19706766	0	nuclear_factor-kappaB	58,79	p65	80,83	nuclear factor-kappaB	p65	4790	5970	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	MUC1-C oncoprotein functions as a direct activator of the nuclear_factor-kappaB p65 transcription factor .
12882758	0	nuclear_factor-kappaB	95,116	phospholipase_A2	64,80	nuclear factor-kappaB	phospholipase A2	4790	151056	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|amod|END_ENTITY	Surfactant_protein-A and phosphatidylglycerol suppress type IIA phospholipase_A2 synthesis via nuclear_factor-kappaB .
16581947	0	nuclear_factor-kappaB	163,184	transforming_growth_factor_alpha	101,133	nuclear factor-kappaB	transforming growth factor alpha	4790	7124	Gene	Gene	activation|nmod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Hepatitis_C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming_growth_factor_alpha expression via activation of nuclear_factor-kappaB .
15698590	0	nuclear_factor-kappaB	85,106	tumor_necrosis_factor-alpha	39,66	nuclear factor-kappaB	tumor necrosis factor-alpha	4790	7124	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Fluvastatin inhibits the expression of tumor_necrosis_factor-alpha and activation of nuclear_factor-kappaB in human endothelial cells stimulated by C-reactive_protein .
17975021	0	nuclear_factor-kappaB	13,34	tumor_necrosis_factor_alpha	107,134	nuclear factor-kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	Interplay|nmod|START_ENTITY Interplay|nmod|END_ENTITY	Interplay of nuclear_factor-kappaB and B-myb in the negative regulation of androgen_receptor expression by tumor_necrosis_factor_alpha .
15655349	0	nuclear_factor-kappa_B	71,93	COX-2	45,50	nuclear factor-kappa B	COX-2	4790	5743	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
11377405	0	nuclear_factor-kappa_B	15,37	NF-kappaB	39,48	nuclear factor-kappa B	NF-kappaB	4790	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Involvement of nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activation in mitogen-induced lymphocyte proliferation : inhibitory effects of lymphoproliferation by salicylates acting as NF-kappaB inhibitors .
17499901	0	nuclear_factor-kappa_B	158,180	NF-kappaB	182,191	nuclear factor-kappa B	NF-kappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Dexamethasone protects RAW264 .7 macrophages from growth arrest and apoptosis induced by H2O2 through alteration of gene expression patterns and inhibition of nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activity .
19617655	0	nuclear_factor-kappa_B	83,105	NF-kappaB	107,116	nuclear factor-kappa B	NF-kappaB	4790	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- activation .
20398679	0	nuclear_factor-kappa_B	18,40	NF-kappaB	42,51	nuclear factor-kappa B	NF-kappaB	4790	4790	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Downregulation of nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- pathway by silibinin in human monocytes challenged with Paracoccidioides_brasiliensis .
11887466	0	nuclear_factor-kappa_B	8,30	NF-kappa_B	32,42	nuclear factor-kappa B	NF-kappa B	4790	4790	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of nuclear_factor-kappa_B -LRB- NF-kappa_B -RRB- in inflammation , periodontitis , and atherogenesis .
19892878	0	nuclear_factor-kappa_B	38,60	NF_kappa_B	62,72	nuclear factor-kappa B	NF kappa B	4790	4790	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Characterizing the involvement of the nuclear_factor-kappa_B -LRB- NF_kappa_B -RRB- transcription factor in uveal_melanoma .
14611907	0	nuclear_factor-kappa_B	36,58	NFkappaB	60,68	nuclear factor-kappa B	NFkappaB	4790	4790	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	A flow cytometry technique to study nuclear_factor-kappa_B -LRB- NFkappaB -RRB- translocation during human B_cell_activation .
11007940	0	nuclear_factor-kappa_B	14,36	activator_protein-1	38,57	nuclear factor-kappa B	activator protein-1	4790	3725	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Regulation of nuclear_factor-kappa_B , activator_protein-1 , and glutathione levels by tumor_necrosis_factor-alpha and dexamethasone in alveolar epithelial cells .
12771929	0	nuclear_factor-kappa_B	75,97	cyclooxygenase-2	16,32	nuclear factor-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	expression|nmod|START_ENTITY accompanied|nmod|expression accompanied|nsubjpass|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear_factor-kappa_B and I_kappa_B_kinase-alpha in human colorectal_cancer epithelial cells .
15655349	0	nuclear_factor-kappa_B	71,93	cyclooxygenase-2	27,43	nuclear factor-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Selenomethionine regulates cyclooxygenase-2 -LRB- COX-2 -RRB- expression through nuclear_factor-kappa_B -LRB- NF-kappaB -RRB- in colon_cancer cells .
16841079	0	nuclear_factor-kappa_B	19,41	cyclooxygenase-2	45,61	nuclear factor-kappa B	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	START_ENTITY|nmod|overexpression overexpression|amod|END_ENTITY	The involvement of nuclear_factor-kappa_B in cyclooxygenase-2 overexpression in murine colon_cancer cells transduced with herpes simplex virus thymidine kinase gene .
17335379	0	nuclear_factor-kappa_B	110,132	cyclooxygenase-2	12,28	nuclear factor-kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|inhibitor inhibitor|amod|END_ENTITY	Effect of a cyclooxygenase-2 inhibitor on interleukin-1beta-stimulated activation of the transcription factor nuclear_factor-kappa_B in human gingival fibroblasts .
18534633	0	nuclear_factor-kappa_B	51,73	cyclooxygenase-2	15,31	nuclear factor-kappa B	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY inhibits|nmod|activation inhibits|dobj|expression expression|amod|END_ENTITY	Hemin inhibits cyclooxygenase-2 expression through nuclear_factor-kappa_B activation and ornithine_decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin .
15040111	0	nuclear_factor-kappa_B	15,37	inducible_nitric_oxide_synthase	44,75	nuclear factor-kappa B	inducible nitric oxide synthase	4790	4843	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	-LSB- Expression of nuclear_factor-kappa_B mRNA , inducible_nitric_oxide_synthase and interleukin-6 in nasal polyp and its role -RSB- .
12897563	0	nuclear_factor-kappa_B	12,34	interleukin-8	38,51	nuclear factor-kappa B	interleukin-8	4790	3576	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	The role of nuclear_factor-kappa_B in interleukin-8 expression by human adenoidal fibroblasts .
12856595	0	nuclear_factor-kappa_B	16,38	p65	39,42	nuclear factor-kappa B	p65	4790	5970	Gene	Gene	antisense|amod|START_ENTITY antisense|amod|END_ENTITY	-LSB- The effects of nuclear_factor-kappa_B p65 antisense oligonucleotides on expression of proinflammatory cytokines in lamina propria mononuclear cells from patients with ulcerative_colitis -RSB- .
15165104	0	nuclear_factor-kappa_B	10,32	vascular_endothelial_growth_factor	36,70	nuclear factor-kappa B	vascular endothelial growth factor	4790	7422	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effect of nuclear_factor-kappa_B on vascular_endothelial_growth_factor mRNA expression of human pulmonary artery smooth muscle cells in hypoxia .
24854091	0	nuclear_factor_E2-related_factor_2	8,42	Nrf2	44,48	nuclear factor E2-related factor 2	Nrf2	4780	4780	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of nuclear_factor_E2-related_factor_2 -LRB- Nrf2 -RRB- in epidermal differentiation .
2841167	0	nuclear_factor_I	46,62	NFI	64,67	nuclear factor I	NFI	4782	4782	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the porcine nuclear_factor_I -LRB- NFI -RRB- gene .
10518556	0	nuclear_factor_I-A	25,43	Nfia	50,54	nuclear factor I-A	Nfia	18027(Tax:10090)	18027(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disruption of the murine nuclear_factor_I-A gene -LRB- Nfia -RRB- results in perinatal lethality , hydrocephalus , and agenesis of the corpus_callosum .
18199529	0	nuclear_factor_erythroid-derived_2-related_factor_2	62,113	Activating_transcription_factor_3	0,33	nuclear factor erythroid-derived 2-related factor 2	Activating transcription factor 3	4780	467	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	Activating_transcription_factor_3 is a novel repressor of the nuclear_factor_erythroid-derived_2-related_factor_2 -LRB- Nrf2 -RRB- - regulated stress pathway .
24494203	0	nuclear_factor_erythroid_2-related_factor_2	24,67	Cyp2b10	94,101	nuclear factor erythroid 2-related factor 2	Cyp2b10	18024(Tax:10090)	13088(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Possible involvement of nuclear_factor_erythroid_2-related_factor_2 in the gene expression of Cyp2b10 and Cyp2a5 .
26105441	1	nuclear_factor_erythroid_2-related_factor_2	23,66	Nrf2	68,72	nuclear factor erythroid 2-related factor 2	Nrf2	4780	4780	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the nuclear_factor_erythroid_2-related_factor_2 -LRB- Nrf2 -RRB- in preeclampsia .
25171874	0	nuclear_factor_erythroid_2-related_factor_2	14,57	Prdx6	86,91	nuclear factor erythroid 2-related factor 2	Prdx6	4780	9588	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Expression of nuclear_factor_erythroid_2-related_factor_2 -LRB- Nrf2 -RRB- and peroxiredoxin_6 -LRB- Prdx6 -RRB- proteins in healthy and pathologic placentas of human and rat .
24812425	0	nuclear_factor_erythroid_2-related_factor_2	33,76	angiotensinogen	98,113	nuclear factor erythroid 2-related factor 2	angiotensinogen	18024(Tax:10090)	11606(Tax:10090)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expression expression|compound|END_ENTITY	Catalase overexpression prevents nuclear_factor_erythroid_2-related_factor_2 stimulation of renal angiotensinogen gene expression , hypertension , and kidney_injury in diabetic mice .
16123320	0	nuclear_factor_erythroid_2-related_factor_2	69,112	heme_oxygenase-1	26,42	nuclear factor erythroid 2-related factor 2	heme oxygenase-1	4780	3162	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Alpha-lipoic_acid-induced heme_oxygenase-1 expression is mediated by nuclear_factor_erythroid_2-related_factor_2 and p38_mitogen-activated_protein_kinase in human monocytic cells .
23564451	0	nuclear_factor_kB	137,154	NF-kB	156,161	nuclear factor kB	NF-kB	81736(Tax:10116)	81736(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- promotes both survival and neuritogenesis in PC12 cells through activation of nuclear_factor_kB -LRB- NF-kB -RRB- pathway : involvement of extracellular_signal-regulated_kinase -LRB- ERK -RRB- , calcium , and c-REL .
17222729	0	nuclear_factor_kappa-B	25,47	C-reactive_protein	223,241	nuclear factor kappa-B	C-reactive protein	4790	1401	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Persistent activation of nuclear_factor_kappa-B signaling pathway in patients with unstable_angina and elevated levels of C-reactive_protein evidence for a direct proinflammatory effect of azide and lipopolysaccharide-free C-reactive_protein on human monocytes via nuclear_factor_kappa-B activation .
19343319	0	nuclear_factor_kappa-B	71,93	NF-kappaB	95,104	nuclear factor kappa-B	NF-kappaB	4790	4790	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear_factor_kappa-B -LRB- NF-kappaB -RRB- signalling in human islets and in a mouse beta cell line .
12740336	0	nuclear_factor_kappaB	18,39	Gastrin	0,7	nuclear factor kappaB	Gastrin	4790	2520	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Gastrin activates nuclear_factor_kappaB -LRB- NFkappaB -RRB- through a protein kinase C dependent pathway involving NFkappaB inducing kinase , inhibitor kappaB -LRB- IkappaB -RRB- kinase , and tumour_necrosis_factor_receptor_associated_factor_6 -LRB- TRAF6 -RRB- in MKN-28 cells transfected with gastrin_receptor .
10336492	0	nuclear_factor_kappaB	10,31	NF-kappaB	33,42	nuclear factor kappaB	NF-kappaB	4790	4790	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Transient nuclear_factor_kappaB -LRB- NF-kappaB -RRB- activation stimulated by interleukin-1beta may be partly dependent on proteasome activity , but not phosphorylation and ubiquitination of the IkappaBalpha molecule , in C6_glioma cells .
10652294	0	nuclear_factor_kappaB	37,58	Rac1	0,4	nuclear factor kappaB	Rac1	4790	5879	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Rac1 regulates interleukin_1-induced nuclear_factor_kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression .
19539355	0	nuclear_factor_kappaB	112,133	Syndecan-1	0,10	nuclear factor kappaB	Syndecan-1	4790	6382	Gene	Gene	modulating|nmod|START_ENTITY enhances|advcl|modulating enhances|nsubj|END_ENTITY	Syndecan-1 enhances the endometrial_cancer_invasion by modulating matrix_metalloproteinase-9 expression through nuclear_factor_kappaB .
16857964	0	nuclear_factor_kappaB	42,63	Transforming_growth_factor-alpha	0,32	nuclear factor kappaB	Transforming growth factor-alpha	18033(Tax:10090)	21802(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Transforming_growth_factor-alpha mediates nuclear_factor_kappaB activation in strained arteries .
16757480	0	nuclear_factor_kappaB	85,106	Tumor_necrosis_factor_alpha	0,27	nuclear factor kappaB	Tumor necrosis factor alpha	4790	7124	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces spermidine/spermine N1-acetyltransferase through nuclear_factor_kappaB in non-small_cell_lung_cancer cells .
16269535	0	nuclear_factor_kappaB	178,199	cyclooxygenase-2	200,216	nuclear factor kappaB	cyclooxygenase-2	18033(Tax:10090)	19225(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Gene transfer of pro-opiomelanocortin prohormone suppressed the growth and metastasis of melanoma : involvement of alpha-melanocyte-stimulating_hormone-mediated inhibition of the nuclear_factor_kappaB / cyclooxygenase-2 pathway .
11431008	0	nuclear_factor_kappaB	69,90	interleukin-6	14,27	nuclear factor kappaB	interleukin-6	18033(Tax:10090)	16193(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of interleukin-6 gene expression in brain of aged mice by nuclear_factor_kappaB .
15087380	0	nuclear_factor_kappaB	109,130	tumor_necrosis_factor_alpha	50,77	nuclear factor kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	counteracted|nmod|START_ENTITY counteracted|nsubjpass|cleavage cleavage|nmod|response response|nmod|stimulation stimulation|compound|END_ENTITY	Caspase-8-dependent HER-2 cleavage in response to tumor_necrosis_factor_alpha stimulation is counteracted by nuclear_factor_kappaB through c-FLIP-L expression .
17363555	0	nuclear_factor_kappaB	20,41	tumor_necrosis_factor_alpha	56,83	nuclear factor kappaB	tumor necrosis factor alpha	4790	7124	Gene	Gene	activation|amod|START_ENTITY enhances|dobj|activation enhances|nmod|END_ENTITY	Mutant p53 enhances nuclear_factor_kappaB activation by tumor_necrosis_factor_alpha in cancer cells .
8349609	0	nuclear_factor_kappa_B	63,85	50-kDa	86,92	nuclear factor kappa B	50-kDa	18033(Tax:10090)	18972(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Lipopolysaccharide stimulates both nuclear localization of the nuclear_factor_kappa_B 50-kDa subunit and loss of the 105-kDa precursor in RAW264 macrophage-like cells .
11903618	0	nuclear_factor_kappa_B	80,102	Granulocyte-macrophage_colony-stimulating_factor	0,48	nuclear factor kappa B	Granulocyte-macrophage colony-stimulating factor	4790	1437	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor activates the transcription of nuclear_factor_kappa_B and induces the expression of nitric_oxide synthase in a skin dendritic cell line .
15811753	0	nuclear_factor_kappa_B	27,49	NF-kappaB	51,60	nuclear factor kappa B	NF-kappaB	4790	4790	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Cellular_death mediated by nuclear_factor_kappa_B -LRB- NF-kappaB -RRB- translocation in cultured human lens epithelial cells after ultraviolet-B irradiation .
9822350	0	nuclear_factor_kappa_B	14,36	NF-kappaB	38,47	nuclear factor kappa B	NF-kappaB	4790	4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of nuclear_factor_kappa_B -LRB- NF-kappaB -RRB- assayed by laser scanning cytometry -LRB- LSC -RRB- .
7986199	0	nuclear_factor_kappa_B	51,73	NF-kappa_B	75,85	nuclear factor kappa B	NF-kappa B	4790	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Pyrrolidine_dithiocarbamate , a potent inhibitor of nuclear_factor_kappa_B -LRB- NF-kappa_B -RRB- activation , prevents apoptosis in human promyelocytic_leukemia HL-60 cells and thymocytes .
7721885	0	nuclear_factor_kappa_B	29,51	NF_kappa_B	53,63	nuclear factor kappa B	NF kappa B	4790	4790	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Interleukin _ -LRB- IL -RRB- -10 inhibits nuclear_factor_kappa_B -LRB- NF_kappa_B -RRB- activation in human monocytes .
8151120	0	nuclear_factor_kappa_B	18,40	NF_kappa_B	42,52	nuclear factor kappa B	NF kappa B	4790	4790	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	UVB light induces nuclear_factor_kappa_B -LRB- NF_kappa_B -RRB- activity independently from chromosomal DNA damage in cell-free cytosolic extracts .
16328384	0	nuclear_factor_kappa_B	14,36	NFkappaB	38,46	nuclear factor kappa B	NFkappaB	4790	4790	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of nuclear_factor_kappa_B -LRB- NFkappaB -RRB- activity in oral_tumor cells prevents depletion of NK cells and increases their functional activation .
19325136	0	nuclear_factor_kappa_B	75,97	beta-arrestin2	137,151	nuclear factor kappa B	beta-arrestin2	4790	409	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|END_ENTITY	The type III transforming growth factor-beta receptor negatively regulates nuclear_factor_kappa_B signaling through its interaction with beta-arrestin2 .
9041934	0	nuclear_factor_kappa_B	15,37	cyclooxygenase-2	59,75	nuclear factor kappa B	cyclooxygenase-2	4790	5743	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Involvement of nuclear_factor_kappa_B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid_synoviocytes .
9041934	0	nuclear_factor_kappa_B	15,37	interleukin-1	90,103	nuclear factor kappa B	interleukin-1	4790	3552	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of nuclear_factor_kappa_B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid_synoviocytes .
15956726	0	nuclear_factor_kappa_B	65,87	matrix_metalloproteinase-9	16,42	nuclear factor kappa B	matrix metalloproteinase-9	4790	4318	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Relaxin induces matrix_metalloproteinase-9 through activation of nuclear_factor_kappa_B in human THP-1 cells .
19609608	0	nuclear_factor_kappa_B	14,36	migration_inhibitory_factor	54,81	nuclear factor kappa B	migration inhibitory factor	4790	4282	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of nuclear_factor_kappa_B and induction of migration_inhibitory_factor in tumors by surgical stress of laparotomy versus carbon_dioxide pneumoperitoneum : an animal experiment .
24146067	0	nuclear_factor_kappa_B	23,45	p65	64,67	nuclear factor kappa B	p65	309165(Tax:10116)	25716(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Biphasic activation of nuclear_factor_kappa_B and expression of p65 and c-Rel after traumatic_brain_injury in rats .
12600083	0	nuclear_factor_kappa_Bp65	21,46	NF_kappa_Bp65	48,61	nuclear factor kappa Bp65	NF kappa Bp65	5970	5970	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- The significance of nuclear_factor_kappa_Bp65 -LRB- NF_kappa_Bp65 -RRB- expression on the vascular endothelial cells of rectum adenocarcinoma of human -RSB- .
23060442	0	nuclear_factor_of_activated_T_cell_1	237,273	NFAT1	275,280	nuclear factor of activated T cell 1	NFAT1	4773	4773	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 -LRB- VEGFR2 -RRB- - evoked signaling pathways : transcriptional repression of hypoxia-inducible_factor_1a and VEGFA and concurrent inhibition of nuclear_factor_of_activated_T_cell_1 -LRB- NFAT1 -RRB- activation .
18156209	0	nuclear_factor_of_activated_T_cell_1	42,78	NFATC1	80,86	nuclear factor of activated T cell 1	NFATC1	4772	4772	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Epigenetic changes and suppression of the nuclear_factor_of_activated_T_cell_1 -LRB- NFATC1 -RRB- promoter in human lymphomas with defects in immunoreceptor signaling .
18081741	0	nuclear_factor_of_activated_T_cells_1	68,105	NFAT_1	107,113	nuclear factor of activated T cells 1	NFAT 1	4773	4773	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Disrupted intracellular calcium regulates BACE1 gene expression via nuclear_factor_of_activated_T_cells_1 -LRB- NFAT_1 -RRB- signaling .
23233732	0	nuclear_factor_of_activated_T_cells_5	34,71	Fat-specific_protein_27	0,23	nuclear factor of activated T cells 5	Fat-specific protein 27	10725	63924	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Fat-specific_protein_27 modulates nuclear_factor_of_activated_T_cells_5 and the cellular response to stress .
11583354	0	nuclear_matrix_protein_22	14,39	NMP22	41,46	nuclear matrix protein 22	NMP22	4926	4926	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of nuclear_matrix_protein_22 -LRB- NMP22 -RRB- as a tumor marker in the detection of bladder_cancer .
9076459	0	nuclear_matrix_protein_22	23,48	NMP22	50,55	nuclear matrix protein 22	NMP22	4926	4926	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Clinical evaluation of nuclear_matrix_protein_22 -LRB- NMP22 -RRB- in urine as a novel marker for urothelial_cancer .
14566681	0	nuclear_matrix_protein_22	32,57	NMP_22	24,30	nuclear matrix protein 22	NMP 22	4926	4926	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Clinical study of urine NMP_22 -LRB- nuclear_matrix_protein_22 -RRB- as a tumor marker in urinary_epithelial_cancer .
19153668	0	nuclear_protein_1	17,34	NUPR1	36,41	nuclear protein 1	NUPR1	100912108	100912108	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Emerging role of nuclear_protein_1 -LRB- NUPR1 -RRB- in cancer biology .
24497499	0	nuclear_protein_1	31,48	matrix_metalloproteinase_13	59,86	nuclear protein 1	matrix metalloproteinase 13	26471	4322	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Brief report : stress-inducible nuclear_protein_1 regulates matrix_metalloproteinase_13 expression in human articular chondrocytes .
22887959	0	nuclear_receptor_co-repressor	143,172	N-CoR	174,179	nuclear receptor co-repressor	N-CoR	9611	9611	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Curcumin analogues with potent and selective anti-proliferative activity on acute_promyelocytic_leukemia : involvement of accumulated misfolded nuclear_receptor_co-repressor -LRB- N-CoR -RRB- protein as a basis for selective activity .
17939029	0	nuclear_receptor_co-repressor_1	12,43	NCOR1	45,50	nuclear receptor co-repressor 1	NCOR1	100037950(Tax:9823)	100037950(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The porcine nuclear_receptor_co-repressor_1 -LRB- NCOR1 -RRB- gene : chromosome location , expression profile , and polymorphism .
22977234	0	nuclear_receptor_coactivator_3	8,38	Ncoa3	40,45	nuclear receptor coactivator 3	Ncoa3	17979(Tax:10090)	17979(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of nuclear_receptor_coactivator_3 -LRB- Ncoa3 -RRB- in pluripotency maintenance .
20354146	0	nuclear_receptor_coactivator_4	23,53	NcoA4	55,60	nuclear receptor coactivator 4	NcoA4	27057(Tax:10090)	27057(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Variable expression of nuclear_receptor_coactivator_4 -LRB- NcoA4 -RRB- during mouse embryonic development .
19414341	0	nuclear_receptor_corepressor	17,45	NCoR	47,51	nuclear receptor corepressor	NCoR	9611	9611	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of nuclear_receptor_corepressor -LRB- NCoR -RRB- in progestin-induced growth suppression of endometrial_hyperplasia_and_carcinoma .
16195251	0	nuclear_receptor_corepressor	120,148	SAFB1	27,32	nuclear receptor corepressor	SAFB1	9611	6294	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Scaffold attachment factor SAFB1 suppresses estrogen_receptor_alpha-mediated transcription in part via interaction with nuclear_receptor_corepressor .
12089345	0	nuclear_receptor_corepressor	69,97	androgen_receptor	48,65	nuclear receptor corepressor	androgen receptor	9611	367	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the dihydrotestosterone-activated androgen_receptor by nuclear_receptor_corepressor .
25408954	0	nuclear_receptor_related_1	74,100	Nurr1	110,115	nuclear receptor related 1	Nurr1	4929	4929	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Effect of spontaneous term labour on the expression of the NR4A receptors nuclear_receptor_related_1 protein -LRB- Nurr1 -RRB- , neuron-derived clone 77 -LRB- Nur77 -RRB- and neuron-derived_orphan_receptor_1 -LRB- NOR1 -RRB- in human fetal membranes and myometrium .
10381170	0	nuclear_respiratory_factor_1	69,97	CXCR4	34,39	nuclear respiratory factor 1	CXCR4	4899	7852	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	HTLV type I Tax activation of the CXCR4 promoter by association with nuclear_respiratory_factor_1 .
16864783	0	nuclear_respiratory_factor_1	24,52	Cyclin_D1	0,9	nuclear respiratory factor 1	Cyclin D1	4899	595	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Cyclin_D1 repression of nuclear_respiratory_factor_1 integrates nuclear DNA synthesis and mitochondrial function .
20724482	0	nuclear_respiratory_factor_1	76,104	PCFT	45,49	nuclear respiratory factor 1	PCFT	4899	113235	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The obligatory intestinal folate transporter PCFT -LRB- SLC46A1 -RRB- is regulated by nuclear_respiratory_factor_1 .
10381170	0	nuclear_respiratory_factor_1	69,97	Tax	12,15	nuclear respiratory factor 1	Tax	4899	6900	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	HTLV type I Tax activation of the CXCR4 promoter by association with nuclear_respiratory_factor_1 .
18071027	0	nuclear_respiratory_factor_1	50,78	nRF1	80,84	nuclear respiratory factor 1	nRF1	4899	4899	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation and association analyses of the nuclear_respiratory_factor_1 -LRB- nRF1 -RRB- gene in Chinese patients with type 2 diabetes .
19682578	0	nuclear_restrict_protein_in_brain	25,58	Nrp/b	18,23	nuclear restrict protein in brain	Nrp/b	13803(Tax:10090)	13803(Tax:10090)	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Nrp/b -LRB- nuclear_restrict_protein_in_brain -RRB- suppresses the malignant phenotype in the C6/ST1 glioma cell line .
19940103	0	nuclear_transcription_factor-kappaB	117,152	silent_mating_type_information_regulation-1	54,97	nuclear transcription factor-kappaB	silent mating type information regulation-1	18033(Tax:10090)	93759(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Resveratrol -LRB- trans-3 ,5,4 ' - trihydroxystilbene -RRB- induces silent_mating_type_information_regulation-1 and down-regulates nuclear_transcription_factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis .
10908156	0	nuclear_transcription_factor_kB	99,130	NF-kB	132,137	nuclear transcription factor kB	NF-kB	309165(Tax:10116)	309165(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Interaction of the receptor for advanced glycation end products -LRB- RAGE -RRB- with transthyretin triggers nuclear_transcription_factor_kB -LRB- NF-kB -RRB- activation .
26498772	0	nuclear_transporter	16,35	Kpnb1	37,42	nuclear transporter	Kpnb1	84268	3837	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of nuclear_transporter , Kpnb1 , contributes to accelerated cell proliferation - and cell adhesion-mediated drug resistance -LRB- CAM-DR -RRB- in diffuse_large_B-cell_lymphoma .
7530050	0	nuclease	24,32	Rrp1	56,60	nuclease	Rrp1	5656958	33500(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Characterization of the nuclease activity of Drosophila Rrp1 on phosphoglycolate - and phosphate-modified DNA 3 ' - termini .
25038744	0	nucleobindin_1	14,28	NUCB1	30,35	nucleobindin 1	NUCB1	18220(Tax:10090)	18220(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of nucleobindin_1 -LRB- NUCB1 -RRB- in pancreatic islets and other endocrine tissues .
23266808	0	nucleobindin_2	21,35	NUCB2	42,47	nucleobindin 2	NUCB2	4925	4925	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association of a nucleobindin_2 gene -LRB- NUCB2 -RRB- variant with childhood adiposity .
11445251	0	nucleolin	24,33	Cdc2	0,4	nucleolin	Cdc2	4691	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer 's _ disease pathology .
12565890	0	nucleolin	55,64	Centaurin-alpha_1	0,17	nucleolin	Centaurin-alpha 1	4691	11033	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Centaurin-alpha_1 associates in vitro and in vivo with nucleolin .
18523588	0	nucleolin	18,27	ErbB	35,39	nucleolin	ErbB	4691	1956	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Identification of nucleolin as new ErbB receptors - interacting protein .
24333432	0	nucleolin	52,61	HIF1a	27,32	nucleolin	HIF1a	4691	3091	Gene	Gene	stability|nmod|START_ENTITY stability|amod|END_ENTITY	GSK3b negatively regulates HIF1a mRNA stability via nucleolin in the MG63 osteosarcoma cell line .
22103682	0	nucleolin	20,29	Hdm2	44,48	nucleolin	Hdm2	4691	4193	Gene	Gene	domains|nmod|START_ENTITY interact|nsubj|domains interact|nmod|END_ENTITY	Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination .
22743058	0	nucleolin	77,86	Heat_shock_cognate_70	0,21	nucleolin	Heat shock cognate 70	4691	3312	Gene	Gene	function|nmod|START_ENTITY regulates|dobj|function regulates|nsubj|END_ENTITY	Heat_shock_cognate_70 regulates the translocation and angiogenic function of nucleolin .
21998300	0	nucleolin	33,42	Heat_shock_protein_90	0,21	nucleolin	Heat shock protein 90	4691	3320	Gene	Gene	stabilizes|xcomp|START_ENTITY stabilizes|nsubj|END_ENTITY	Heat_shock_protein_90 stabilizes nucleolin to increase mRNA stability in mitosis .
25938538	0	nucleolin	31,40	Hepatoma-derived_growth_factor	0,30	nucleolin	Hepatoma-derived growth factor	4691	3068	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|appos|axis	Hepatoma-derived_growth_factor / nucleolin axis as a novel oncogenic pathway in liver_carcinogenesis .
7683660	0	nucleolin	39,48	Insulin	0,7	nucleolin	Insulin	4691	3630	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Insulin induces the phosphorylation of nucleolin .
16153722	0	nucleolin	8,17	MMP-9	52,57	nucleolin	MMP-9	4691	4318	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of nucleolin in posttranscriptional control of MMP-9 expression .
10606642	0	nucleolin	16,25	Myc	0,3	nucleolin	Myc	4691	4609	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Myc induces the nucleolin and BN51 genes : possible implications in ribosome biogenesis .
17971306	0	nucleolin	6,15	RNAh	30,34	nucleolin	RNAh	17975(Tax:10090)	77987(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Mouse nucleolin binds to 4.5 S RNAh , a small noncoding RNA .
17346762	0	nucleolin	67,76	UL24	15,19	nucleolin	UL24	4691	24271468	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of UL24 in herpes-simplex-virus-1-induced dispersal of nucleolin .
18420791	0	nucleolin	125,134	UL24	58,62	nucleolin	UL24	4691	24271468	Gene	Gene	redistribution|nmod|START_ENTITY induce|dobj|redistribution sufficient|xcomp|induce sufficient|nsubj|domain domain|nmod|protein protein|compound|END_ENTITY	The conserved N-terminal domain of herpes_simplex_virus_1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin .
19864385	0	nucleolin	118,127	UL24	26,30	nucleolin	UL24	4691	24271468	Gene	Gene	dispersal|nmod|START_ENTITY important|nmod|dispersal important|nsubj|residues residues|nmod|protein protein|compound|END_ENTITY	Conserved residues in the UL24 protein of herpes_simplex_virus_1 are important for dispersal of the nucleolar protein nucleolin .
20571027	0	nucleolin	41,50	bcl-2	27,32	nucleolin	bcl-2	4691	596	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U - rich_element-binding_factor_1 -LRB- AUF1 -RRB- .
11162542	0	nucleolin	18,27	glucocorticoid_receptor	33,56	nucleolin	glucocorticoid receptor	4691	2908	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Identification of nucleolin as a glucocorticoid_receptor interacting protein .
8749721	0	nucleolin	73,82	myeloid_cell_nuclear_differentiation_antigen	6,50	nucleolin	myeloid cell nuclear differentiation antigen	4691	4332	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human myeloid_cell_nuclear_differentiation_antigen binds specifically to nucleolin .
16403913	0	nucleolin	27,36	myosin	101,107	nucleolin	myosin	4691	79784	Gene	Gene	function|nmod|START_ENTITY mediated|nsubjpass|function mediated|nmod|END_ENTITY	The angiogenic function of nucleolin is mediated by vascular_endothelial_growth_factor and nonmuscle myosin .
2192260	0	nucleolin	36,45	p34cdc2	49,56	nucleolin	p34cdc2	4691	983	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase .
20860603	0	nucleolin	85,94	phosphatase_of_regenerating_liver-3	15,50	nucleolin	phosphatase of regenerating liver-3	4691	11156	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|nmod|END_ENTITY	Requirement of phosphatase_of_regenerating_liver-3 for the nucleolar localization of nucleolin during the progression of colorectal_carcinoma .
19570216	0	nucleolin_related_protein	26,51	NRP	53,56	nucleolin related protein	NRP	64556(Tax:10116)	64556(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a novel nucleolin_related_protein -LRB- NRP -RRB- gene expressed during rat spermatogenesis .
25818168	0	nucleophosmin	45,58	GLTSCR2	0,7	nucleophosmin	GLTSCR2	4869	29997	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer .
22467873	0	nucleophosmin	51,64	G_protein-coupled_receptor_kinase_5	0,35	nucleophosmin	G protein-coupled receptor kinase 5	4869	2869	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	G_protein-coupled_receptor_kinase_5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like_kinase_1 inhibition .
22099964	0	nucleophosmin	23,36	NPM-1	38,43	nucleophosmin	NPM-1	4869	4869	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel mutations of the nucleophosmin -LRB- NPM-1 -RRB- gene in Egyptian patients with acute_myeloid_leukemia : a pilot study .
17488663	0	nucleophosmin	43,56	NPM1	58,62	nucleophosmin	NPM1	4869	4869	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Translocations and mutations involving the nucleophosmin -LRB- NPM1 -RRB- gene in lymphomas and leukemias .
21791474	0	nucleophosmin	73,86	NPM1	88,92	nucleophosmin	NPM1	4869	4869	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	High CD33 expression levels in acute_myeloid_leukemia cells carrying the nucleophosmin -LRB- NPM1 -RRB- mutation .
18175937	0	nucleophosmin	42,55	Nup88	79,84	nucleophosmin	Nup88	4869	4927	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Deguelin represses both the expression of nucleophosmin and some nucleoporins : Nup88 and Nup214 in Jurkat cells .
11522649	0	nucleophosmin	62,75	signal_transducer_and_activator_of_transcription_5	8,58	nucleophosmin	signal transducer and activator of transcription 5	18148(Tax:10090)	20850(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_5 in nucleophosmin / anaplastic_lymphoma_kinase-mediated malignant transformation of lymphoid cells .
9092633	0	nucleophosmin/B23	44,61	NPM	63,66	nucleophosmin/B23	NPM	4869	4869	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the human nucleophosmin/B23 -LRB- NPM -RRB- gene : identification of the YY1 binding site at the 5 ' enhancer region .
9166830	0	nucleoporin	122,133	NUP98	140,145	nucleoporin	NUP98	3268	4928	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The inv -LRB- 11 -RRB- -LRB- p15q22 -RRB- chromosome translocation of de novo and therapy-related myeloid_malignancies results in fusion of the nucleoporin gene , NUP98 , with the putative RNA helicase gene , DDX10 .
24563354	0	nucleoporin	13,24	Tpr	25,28	nucleoporin	Tpr	3268	7175	Gene	Gene	Roles|nmod|START_ENTITY END_ENTITY|nsubj|Roles	Roles of the nucleoporin Tpr in cancer and aging .
9732281	0	nucleoporin	110,121	nup155	92,98	nucleoporin	nup155	36830(Tax:7227)	34527(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Nup154 , a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene .
12034489	0	nucleoporin_155	80,95	NUP155	97,103	nucleoporin 155	NUP155	9631	9631	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization , transcript variants and comparative analysis of the human nucleoporin_155 -LRB- NUP155 -RRB- gene .
7531196	0	nucleoporin_p54	92,107	p62	129,132	nucleoporin p54	p62	53372(Tax:10116)	117268(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores : binding of nucleoporin_p54 to the rod domain of p62 .
16604061	0	nucleoredoxin	49,62	dishevelled	108,119	nucleoredoxin	dishevelled	64359	8215	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled .
11872741	0	nucleoside-diphosphate_kinase	29,58	phocein	16,23	nucleoside-diphosphate kinase	phocein	298410(Tax:10116)	171050(Tax:10116)	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of phocein with nucleoside-diphosphate_kinase , Eps15 , and Dynamin_I .
7665595	0	nucleoside_diphosphate_kinase	40,69	ATP-citrate_lyase	19,36	nucleoside diphosphate kinase	ATP-citrate lyase	298410(Tax:10116)	24159(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of ATP-citrate_lyase by nucleoside_diphosphate_kinase .
25234227	0	nucleoside_diphosphate_kinase	49,78	NDPK	80,84	nucleoside diphosphate kinase	NDPK	129607	129607	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Modulation of cytoskeletal dynamics by mammalian nucleoside_diphosphate_kinase -LRB- NDPK -RRB- proteins .
1659843	0	nucleoside_diphosphate_kinase	18,47	Nm23	49,53	nucleoside diphosphate kinase	Nm23	129607	4830	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of nucleoside_diphosphate_kinase -LRB- Nm23 -RRB- in solid tumours .
20531280	0	nucleosome-binding_protein_1	22,50	NSBP1	52,57	nucleosome-binding protein 1	NSBP1	79366	79366	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Downregulation of the nucleosome-binding_protein_1 -LRB- NSBP1 -RRB- gene can inhibit the in vitro and in vivo proliferation of prostate_cancer cells .
10547286	0	nucleosome_assembly_protein-1	45,74	Casein_kinase_2	0,15	nucleosome assembly protein-1	Casein kinase 2	37798(Tax:7227)	48448(Tax:7227)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Casein_kinase_2 binds and phosphorylates the nucleosome_assembly_protein-1 -LRB- NAP1 -RRB- in Drosophila_melanogaster .
9325046	0	nucleosome_assembly_protein-2	37,66	NAP1L4	68,74	nucleosome assembly protein-2	NAP1L4	4676	4676	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of human nucleosome_assembly_protein-2 -LRB- NAP1L4 -RRB- suggests a role as a histone chaperone .
17965550	0	nucleosome_assembly_protein_1	23,52	NAP1	54,58	nucleosome assembly protein 1	NAP1	561894(Tax:7955)	561894(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Abundant expression of nucleosome_assembly_protein_1 -LRB- NAP1 -RRB- gene in goldfish scale with lateral line .
26241676	0	nucleosome_assembly_protein_1	18,47	ribosomal_protein_S6	90,110	nucleosome assembly protein 1	ribosomal protein S6	818077(Tax:3702)	829298(Tax:3702)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|partner partner|nmod|END_ENTITY	Identification of nucleosome_assembly_protein_1 -LRB- NAP1 -RRB- as an interacting partner of plant ribosomal_protein_S6 -LRB- RPS6 -RRB- and a positive regulator of rDNA transcription .
17976375	0	nucleosome_releasing_factor	9,36	serine_protease	48,63	nucleosome releasing factor	serine protease	55922	2147	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	A plasma nucleosome_releasing_factor -LRB- NRF -RRB- with serine_protease activity is instrumental in removal of nucleosomes from secondary necrotic cells .
24762489	0	nucleostemin	14,26	CD133	46,51	nucleostemin	CD133	26354	8842	Gene	Gene	expression|compound|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Comparison of nucleostemin gene expression in CD133 + and CD133 - cell population in colon_cancer cell line HT29 .
19449081	0	nucleostemin	14,26	CDX2	39,43	nucleostemin	CDX2	26354	1045	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of nucleostemin upregulates CDX2 expression in HT29 cells in response to bile_acid exposure : implications in the pathogenesis of Barrett 's _ esophagus .
24763828	0	nucleostemin	28,40	Sox2	63,67	nucleostemin	Sox2	26354	6657	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Concomitant upregulation of nucleostemin and downregulation of Sox2 and Klf4 in gastric_adenocarcinoma .
24806487	0	nucleotide-binding_oligomerization_domain_1	61,104	NOD1	106,110	nucleotide-binding oligomerization domain 1	NOD1	10392	10392	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Identification of selective small molecule inhibitors of the nucleotide-binding_oligomerization_domain_1 -LRB- NOD1 -RRB- signaling pathway .
26915562	0	nucleotide-binding_oligomerization_domain_1	8,51	NOD1	53,57	nucleotide-binding oligomerization domain 1	NOD1	10392	10392	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of nucleotide-binding_oligomerization_domain_1 -LRB- NOD1 -RRB- in pericyte-mediated vascular_inflammation .
23936340	0	nucleotide-binding_oligomerization_domain_2	72,115	NOD2	117,121	nucleotide-binding oligomerization domain 2	NOD2	64127	64127	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Identification of benzimidazole_diamides as selective inhibitors of the nucleotide-binding_oligomerization_domain_2 -LRB- NOD2 -RRB- signaling pathway .
25746347	0	nucleotide-binding_oligomerization_domain_2	17,60	NOD2	62,66	nucleotide-binding oligomerization domain 2	NOD2	487286(Tax:9615)	487286(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of nucleotide-binding_oligomerization_domain_2 -LRB- NOD2 -RRB- gene in miniature dachshunds with inflammatory colorectal_polyps .
20519512	0	nucleotide-binding_oligomerization_domain_protein_1	34,85	Nod1	87,91	nucleotide-binding oligomerization domain protein 1	Nod1	10392	10392	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of natural human nucleotide-binding_oligomerization_domain_protein_1 -LRB- Nod1 -RRB- ligands from bacterial culture supernatant for elucidation of immune modulators in the environment .
17907287	0	nucleotide_oligomerization_domain_1	15,50	NOD1	52,56	nucleotide oligomerization domain 1	NOD1	10392	10392	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Influence of a nucleotide_oligomerization_domain_1 -LRB- NOD1 -RRB- polymorphism and NOD2 mutant alleles on Crohn 's _ disease phenotype .
15753091	0	nucleotide_oligomerization_domain_2	23,58	GRIM-19	0,7	nucleotide oligomerization domain 2	GRIM-19	64127	51079	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	GRIM-19 interacts with nucleotide_oligomerization_domain_2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells .
22200976	0	nudix_type_5	8,20	NUDT5	22,27	nudix type 5	NUDT5	11164	11164	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Lowered nudix_type_5 -LRB- NUDT5 -RRB- expression leads to cell cycle retardation in HeLa cells .
17277377	0	nup154	0,6	cup	34,37	nup154	cup	34527(Tax:7227)	33934(Tax:7227)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	nup154 genetically interacts with cup and plays a cell-type-specific function during Drosophila_melanogaster egg-chamber development .
9732281	0	nup155	92,98	nucleoporin	110,121	nup155	nucleoporin	34527(Tax:7227)	36830(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Nup154 , a new Drosophila gene essential for male and female gametogenesis is related to the nup155 vertebrate nucleoporin gene .
7969116	0	nur77	78,83	JunD	15,19	nur77	JunD	79240(Tax:10116)	24518(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Involvement Involvement|nmod|END_ENTITY	Involvement of JunD in transcriptional activation of the orphan_receptor gene nur77 by nerve_growth_factor and membrane depolarization in PC12 cells .
7589118	0	nur77	32,37	NAK-1	15,20	nur77	NAK-1	3164	3164	Gene	Gene	homologue|amod|START_ENTITY END_ENTITY|appos|homologue	Involvement of NAK-1 , the human nur77 homologue , in surface IgM-mediated apoptosis in Burkitt_lymphoma cell line BL41 .
21929602	0	nut	37,40	nut	7,10	nut	nut	256646	256646	Gene	Gene	children|amod|START_ENTITY END_ENTITY|nmod|children	Single nut or total nut avoidance in nut allergic children : outcome of nut challenges to guide exclusion diets .
21929602	0	nut	7,10	nut	37,40	nut	nut	256646	256646	Gene	Gene	START_ENTITY|nmod|children children|amod|END_ENTITY	Single nut or total nut avoidance in nut allergic children : outcome of nut challenges to guide exclusion diets .
2768849	0	oasis	72,77	glucose-6-phosphate_dehydrogenase	83,116	oasis	glucose-6-phosphate dehydrogenase	90993	2539	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	An investigation into the riboflavin status of young Egyptians from the oasis with glucose-6-phosphate_dehydrogenase deficiency .
15255953	0	oatp3	58,63	organic_anion_transporting_polypeptide_3	16,56	oatp3	organic anion transporting polypeptide 3	108096(Tax:10090)	108096(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of organic_anion_transporting_polypeptide_3 -LRB- oatp3 -RRB- in mouse brain parenchymal and capillary endothelial cells .
12006663	0	obesity_receptor_gene-related_protein	44,81	Vps55p	6,12	obesity receptor gene-related protein	Vps55p	54741	54741	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Yeast Vps55p , a functional homolog of human obesity_receptor_gene-related_protein , is involved in late endosome to vacuole trafficking .
20504882	0	occludin	23,31	Nedd4-2	0,7	occludin	Nedd4-2	100506658	23327	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia .
22438576	0	occludin	33,41	Protein_kinase	0,14	occludin	Protein kinase	512405(Tax:9913)	444869(Tax:9913)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Protein_kinase cb phosphorylates occludin regulating tight junction trafficking in vascular_endothelial_growth_factor-induced permeability in vivo .
15056293	0	occludin	61,69	Tie-2	131,136	occludin	Tie-2	83497(Tax:10116)	89804(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|activation activation|compound|END_ENTITY	A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro .
10438525	0	occludin	92,100	Vascular_endothelial_growth_factor	0,34	occludin	Vascular endothelial growth factor	83497(Tax:10116)	83785(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1 .
26221892	0	occludin	97,105	Vascular_endothelial_growth_factor	0,34	occludin	Vascular endothelial growth factor	100506658	7422	Gene	Gene	assembly|amod|START_ENTITY distributions|nmod|assembly affecting|dobj|distributions increases|advcl|affecting increases|nsubj|END_ENTITY	Vascular_endothelial_growth_factor increases GEnC permeability by affecting the distributions of occludin , ZO-1 and tight juction assembly .
26221892	0	occludin	97,105	Vascular_endothelial_growth_factor	0,34	occludin	Vascular endothelial growth factor	100506658	7422	Gene	Gene	assembly|amod|START_ENTITY distributions|nmod|assembly affecting|dobj|distributions increases|advcl|affecting increases|nsubj|END_ENTITY	Vascular_endothelial_growth_factor increases GEnC permeability by affecting the distributions of occludin , ZO-1 and tight juction assembly .
11958524	0	occludin	41,49	ZO-1	74,78	occludin	ZO-1	83497(Tax:10116)	292994(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|appos|END_ENTITY	Diabetes-related changes in rat cerebral occludin and zonula occludens-1 -LRB- ZO-1 -RRB- expression .
12604349	0	occludin	28,36	ZO-1	70,74	occludin	ZO-1	100506658	7082	Gene	Gene	phosphorylation|nmod|START_ENTITY attenuates|nsubj|phosphorylation attenuates|nmod|END_ENTITY	Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1 , ZO-2 , and ZO-3 .
11782481	0	occludin	36,44	itch	103,107	occludin	itch	100506658	83737	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch .
22197032	0	occludin	91,99	matrix_metalloproteinase-9	137,163	occludin	matrix metalloproteinase-9	100506658	4318	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix_metalloproteinase-9 .
10806119	0	occludin	26,34	tumor_necrosis_factor_alpha	59,86	occludin	tumor necrosis factor alpha	100506658	7124	Gene	Gene	promoter|compound|START_ENTITY Expression|nmod|promoter affected|nsubjpass|Expression affected|nmod|END_ENTITY	Expression from the human occludin promoter is affected by tumor_necrosis_factor_alpha and interferon_gamma .
17663824	0	occludin	105,113	tumor_necrosis_factor_alpha	15,42	occludin	tumor necrosis factor alpha	18260(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The impact of tumor_necrosis_factor_alpha on expression of intestinal epithelial tight junction protein occludin in fulminant_hepatic_failure mice model -RSB- .
9836530	0	occludin	149,157	vascular_endothelial_growth_factor	104,138	occludin	vascular endothelial growth factor	83497(Tax:10116)	83785(Tax:10116)	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content : vascular_endothelial_growth_factor decreases occludin in retinal endothelial cells .
9836530	0	occludin	86,94	vascular_endothelial_growth_factor	104,138	occludin	vascular endothelial growth factor	83497(Tax:10116)	83785(Tax:10116)	Gene	Gene	content|compound|START_ENTITY associated|nmod|content associated|parataxis|decreases decreases|nsubj|END_ENTITY	Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content : vascular_endothelial_growth_factor decreases occludin in retinal endothelial cells .
21674298	0	oct-1	12,17	tracheal_antimicrobial_peptide	39,69	oct-1	tracheal antimicrobial peptide	519461(Tax:9913)	286837(Tax:9913)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of oct-1 in the regulation of tracheal_antimicrobial_peptide -LRB- TAP -RRB- and lingual_antimicrobial_peptide -LRB- LAP -RRB- expression in bovine mammary epithelial cells .
23747203	0	oct4	60,64	Klf4	0,4	oct4	Klf4	5460	9314	Gene	Gene	locus|amod|START_ENTITY organizes|nmod|locus organizes|nsubj|END_ENTITY	Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency .
17442571	0	oct4	32,36	Tpt1	0,4	oct4	Tpt1	5460	7178	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	Tpt1 activates transcription of oct4 and nanog in transplanted somatic nuclei .
15830901	0	oct_2	54,59	insulin-like_growth_factor-1	15,43	oct 2	insulin-like growth factor-1	117058(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Alcohol alters insulin-like_growth_factor-1 activated oct_2 POU domain gene expression in the immature female hypothalamus .
26173898	0	octamer-binding_transcription_factor_4	85,123	Oct4	125,129	octamer-binding transcription factor 4	Oct4	18999(Tax:10090)	18999(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Distribution pattern of cytoplasmic organelles , spindle integrity , oxidative stress , octamer-binding_transcription_factor_4 -LRB- Oct4 -RRB- expression and developmental potential of oocytes following multiple superovulation .
15486076	0	octn2	68,73	slc22a5	75,82	octn2	slc22a5	6584	6584	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression , localization , and function of the carnitine transporter octn2 -LRB- slc22a5 -RRB- in human placenta .
13680365	0	oculocutaneous_albinism_1	29,54	Tyrosinase	0,10	oculocutaneous albinism 1	Tyrosinase	7299	7299	Gene	Gene	mutations|nmod|START_ENTITY mutations|amod|END_ENTITY	Tyrosinase gene mutations in oculocutaneous_albinism_1 -LRB- OCA1 -RRB- : definition of the phenotype .
18472969	0	odontogenic_ameloblast-associated_protein	14,55	ODAM	57,61	odontogenic ameloblast-associated protein	ODAM	54959	54959	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of odontogenic_ameloblast-associated_protein -LRB- ODAM -RRB- in dental and other epithelial_neoplasms .
20665536	0	odontogenic_ameloblast-associated_protein	4,45	RUNX2	69,74	odontogenic ameloblast-associated protein	RUNX2	54959	860	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	The odontogenic_ameloblast-associated_protein -LRB- ODAM -RRB- cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20 .
26970073	0	odorant-binding_protein	51,74	OBP	76,79	odorant-binding protein	OBP	29991	29991	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genome-wide identification and characterization of odorant-binding_protein -LRB- OBP -RRB- genes in the malaria vector Anopheles sinensis -LRB- Diptera : Culicidae -RRB- .
18245367	0	odorant-binding_protein	23,46	Obp57d	54,60	odorant-binding protein	Obp57d	246618(Tax:7227)	246671(Tax:7227)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Rapid evolution of two odorant-binding_protein genes , Obp57d and Obp57e , in the Drosophila_melanogaster species group .
18670137	0	odorant-binding_protein	39,62	Obp57d	70,76	odorant-binding protein	Obp57d	246618(Tax:7227)	246671(Tax:7227)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Behavioral analyses of mutants for two odorant-binding_protein genes , Obp57d and Obp57e , in Drosophila_melanogaster .
18854508	0	odorant_receptor	16,32	Emx2	0,4	odorant receptor	Emx2	259026(Tax:10090)	13797(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|amod|END_ENTITY	Emx2 stimulates odorant_receptor gene expression .
12119101	0	odorant_receptor	31,47	MOR28	48,53	odorant receptor	MOR28	258501(Tax:10090)	57269(Tax:10090)	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Genomic analysis of the murine odorant_receptor MOR28 cluster : a possible role of gene conversion in maintaining the olfactory map .
19670418	0	olfactomedin_4	6,20	Reg_IV	56,62	olfactomedin 4	Reg IV	10562	83998	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Serum olfactomedin_4 -LRB- GW112 , hGC-1 -RRB- in combination with Reg_IV is a highly sensitive biomarker for gastric_cancer patients .
12911636	0	olfactory_marker_protein	52,76	Bex	33,36	olfactory marker protein	Bex	18378(Tax:10090)	27018	Gene	Gene	family|nmod|START_ENTITY family|compound|END_ENTITY	Identification of members of the Bex gene family as olfactory_marker_protein -LRB- OMP -RRB- binding partners .
25411508	0	olig2	16,21	Prox1	0,5	olig2	Prox1	50913(Tax:10090)	19130(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Prox1 regulates olig2 expression to modulate binary fate decisions in spinal cord neurons .
19477230	0	oligodendrocyte_lineage_transcription_factor_2	31,77	OLIG2	79,84	oligodendrocyte lineage transcription factor 2	OLIG2	10215	10215	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence that variation in the oligodendrocyte_lineage_transcription_factor_2 -LRB- OLIG2 -RRB- gene is associated with psychosis in Alzheimer 's _ disease .
17630211	0	oligodendrocyte_myelin_glycoprotein	14,49	NgR	67,70	oligodendrocyte myelin glycoprotein	NgR	450224(Tax:10116)	113912(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of oligodendrocyte_myelin_glycoprotein and its receptor NgR after the injury of rat central nervous system .
19580419	0	oligodendrocyte_myelin_glycoprotein	55,90	OMgp	92,96	oligodendrocyte myelin glycoprotein	OMgp	450224(Tax:10116)	450224(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Temporospatial expression and cellular localization of oligodendrocyte_myelin_glycoprotein -LRB- OMgp -RRB- after traumatic spinal_cord_injury in adult rats .
14989603	0	oligodendrocyte_transcription_factor_1	26,64	Olig1	66,71	oligodendrocyte transcription factor 1	Olig1	116448	116448	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of the oligodendrocyte_transcription_factor_1 -LRB- Olig1 -RRB- in brain_tumors .
9144178	0	oligosaccharyltransferase	79,104	DAD1	0,4	oligosaccharyltransferase	DAD1	1650	1603	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	DAD1 , the defender against apoptotic cell death , is a subunit of the mammalian oligosaccharyltransferase .
23606741	0	oligosaccharyltransferase	35,60	OST4	0,4	oligosaccharyltransferase	OST4	1650	100128731	Gene	Gene	subunit|nmod|START_ENTITY subunit|nsubj|END_ENTITY	OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation .
2306116	0	oncomodulin	39,50	glutathione_reductase	14,35	oncomodulin	glutathione reductase	100357024(Tax:9986)	116686(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of glutathione_reductase by oncomodulin .
8125092	0	oncoprotein_18	40,54	Ser16	58,63	oncoprotein 18	Ser16	3925	3190209(Tax:176280)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cell-cycle-regulated phosphorylation of oncoprotein_18 on Ser16 , Ser25 and Ser38 .
21556531	0	oncoprotein_mdm2	6,22	tata-binding_protein	42,62	oncoprotein mdm2	tata-binding protein	4193	6908	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human oncoprotein_mdm2 interacts with the tata-binding_protein in-vitro and in-vivo .
20101226	0	oncostatin-M	63,75	S100A7	0,6	oncostatin-M	S100A7	5008	6278	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	S100A7 -LRB- psoriasin -RRB- is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast_cancer .
14499864	0	oncostatin-M	24,36	vascular_endothelial_growth_factor	59,93	oncostatin-M	vascular endothelial growth factor	5008	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Glycoprotein 130 ligand oncostatin-M induces expression of vascular_endothelial_growth_factor in human adult cardiac myocytes .
22844123	0	oncostatin_M	27,39	Axl	94,97	oncostatin M	Axl	5008	558	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|pathway pathway|compound|END_ENTITY	Prostaglandin_E induces oncostatin_M expression in human chronic wound macrophages through Axl receptor_tyrosine_kinase pathway .
18187666	0	oncostatin_M	76,88	C5a	46,49	oncostatin M	C5a	5008	728	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	In human macrophages the complement component C5a induces the expression of oncostatin_M via AP-1 activation .
25187949	0	oncostatin_M	13,25	CCN1	0,4	oncostatin M	CCN1	5008	3491	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	CCN1 induces oncostatin_M production in osteoblasts via integrin-dependent signal pathways .
1633113	0	oncostatin_M	57,69	EGR-1	14,19	oncostatin M	EGR-1	5008	1958	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of EGR-1 , c-jun , and c-myc gene expression by oncostatin_M .
15240007	0	oncostatin_M	98,110	Erk1/2	34,40	oncostatin M	Erk1/2	18413(Tax:10090)	26417;26413	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin_M in murine fibroblasts .
10843761	0	oncostatin_M	116,128	IL-1alpha	149,158	oncostatin M	IL-1alpha	319086(Tax:9913)	281250(Tax:9913)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Transforming_growth_factor_beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin_M in combination with IL-1alpha .
11022130	0	oncostatin_M	128,140	IL-6	76,80	oncostatin M	IL-6	5008	3569	Gene	Gene	interleukin-11|appos|START_ENTITY IL-6|appos|interleukin-11 cytokines|dep|IL-6 cytokines|amod|interleukin-6 interleukin-6|dep|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
11022130	0	oncostatin_M	128,140	IL-6	98,102	oncostatin M	IL-6	5008	3569	Gene	Gene	interleukin-11|appos|START_ENTITY END_ENTITY|appos|interleukin-11	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
12391243	0	oncostatin_M	13,25	IL-6	69,73	oncostatin M	IL-6	5008	3569	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|dep|regulation regulation|nmod|expression expression|amod|END_ENTITY	Secretion of oncostatin_M by infiltrating neutrophils : regulation of IL-6 and chemokine expression in human mesothelial cells .
1542794	0	oncostatin_M	38,50	IL-6	4,8	oncostatin M	IL-6	5008	3569	Gene	Gene	receptor|compound|START_ENTITY transducer|dep|receptor transducer|compound|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
1918953	0	oncostatin_M	33,45	IL-6	14,18	oncostatin M	IL-6	5008	3569	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of IL-6 expression by oncostatin_M .
23797667	0	oncostatin_M	24,36	IL-6	119,123	oncostatin M	IL-6	18413(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY promotes|nsubj|expression promotes|nmod|role role|nmod|END_ENTITY	Pulmonary expression of oncostatin_M -LRB- OSM -RRB- promotes inducible BALT formation independently of IL-6 , despite a role for IL-6 in OSM-driven pulmonary_inflammation .
23797667	0	oncostatin_M	24,36	IL-6	94,98	oncostatin M	IL-6	18413(Tax:10090)	16193(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY promotes|nsubj|expression promotes|dobj|formation formation|nmod|END_ENTITY	Pulmonary expression of oncostatin_M -LRB- OSM -RRB- promotes inducible BALT formation independently of IL-6 , despite a role for IL-6 in OSM-driven pulmonary_inflammation .
25103368	0	oncostatin_M	108,120	IL-6	12,16	oncostatin M	IL-6	5008	3569	Gene	Gene	receptor|compound|START_ENTITY lack|dobj|receptor reveals|ccomp|lack Analysis|parataxis|reveals Analysis|nmod|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
25103368	0	oncostatin_M	158,170	IL-6	12,16	oncostatin M	IL-6	5008	3569	Gene	Gene	lack|xcomp|START_ENTITY reveals|ccomp|lack Analysis|parataxis|reveals Analysis|nmod|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
8003632	0	oncostatin_M	20,32	IL-6	85,89	oncostatin M	IL-6	5008	3569	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|expression expression|compound|END_ENTITY	Interaction between oncostatin_M , interleukin 1 and prostaglandin_E2 in induction of IL-6 expression in human fibroblasts .
8274294	0	oncostatin_M	120,132	IL-6	169,173	oncostatin M	IL-6	5008	3569	Gene	Gene	effects|nmod|START_ENTITY resistant|nmod|effects Selection|amod|resistant coresistant|nsubj|Selection coresistant|nmod|interleukin_6 interleukin_6|appos|END_ENTITY	Selection and characterization of a variant of human melanoma cell line , A375 resistant to growth inhibitory effects of oncostatin_M -LRB- OM -RRB- : coresistant to interleukin_6 -LRB- IL-6 -RRB- .
8580365	0	oncostatin_M	10,22	IL-6	72,76	oncostatin M	IL-6	289747(Tax:10116)	24498(Tax:10116)	Gene	Gene	START_ENTITY|dobj|expression expression|nmod|receptor receptor|compound|END_ENTITY	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
9374126	0	oncostatin_M	73,85	LDL_receptor	57,69	oncostatin M	LDL receptor	5008	3949	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|END_ENTITY	Novel mechanism of transcriptional activation of hepatic LDL_receptor by oncostatin_M .
1542794	0	oncostatin_M	38,50	LIF_receptor	91,103	oncostatin M	LIF receptor	5008	3977	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
25198901	0	oncostatin_M	15,27	Leptin	0,6	oncostatin M	Leptin	5008	3952	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Leptin induces oncostatin_M production in osteoblasts by downregulating miR-93 through the Akt signaling pathway .
23797667	0	oncostatin_M	24,36	OSM	38,41	oncostatin M	OSM	18413(Tax:10090)	18413(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Pulmonary expression of oncostatin_M -LRB- OSM -RRB- promotes inducible BALT formation independently of IL-6 , despite a role for IL-6 in OSM-driven pulmonary_inflammation .
8422753	0	oncostatin_M	26,38	OSM	45,48	oncostatin M	OSM	5008	5008	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of the human oncostatin_M gene -LRB- OSM -RRB- to chromosome 22q12 , distal to the Ewing 's _ sarcoma breakpoint .
17604327	0	oncostatin_M	26,38	PAI-1	47,52	oncostatin M	PAI-1	5008	5054	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cells cells|amod|END_ENTITY	The inflammatory cytokine oncostatin_M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways .
12531804	0	oncostatin_M	86,98	STAT3	107,112	oncostatin M	STAT3	5008	6774	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|inhibition inhibition|compound|END_ENTITY	Kaposi_sarcoma-associated viral cyclin_K overrides cell growth inhibition mediated by oncostatin_M through STAT3 inhibition .
15377837	0	oncostatin_M	48,60	STAT3	96,101	oncostatin M	STAT3	5008	6774	Gene	Gene	START_ENTITY|nmod|cascade cascade|compound|END_ENTITY	Induction of S100A9 gene expression by cytokine oncostatin_M in breast_cancer cells through the STAT3 signaling cascade .
19097071	0	oncostatin_M	63,75	STAT3	25,30	oncostatin M	STAT3	5008	6774	Gene	Gene	lead|xcomp|START_ENTITY lead|nsubj|activations activations|nmod|Ser727 Ser727|compound|END_ENTITY	Defective activations of STAT3 Ser727 and PKC isoforms lead to oncostatin_M resistance in metastatic melanoma cells .
25713326	0	oncostatin_M	57,69	STAT3	123,128	oncostatin M	STAT3	5008	6774	Gene	Gene	driven|nmod|START_ENTITY expression|acl|driven induction|nmod|expression depends|nsubj|induction depends|nmod|NFkB/RelA NFkB/RelA|compound|END_ENTITY	Synergistic induction of CCL2/MCP -1 expression driven by oncostatin_M and IL-1b in human proximal tubular cells depends on STAT3 and p65 NFkB/RelA .
15240007	0	oncostatin_M	98,110	TIMP-1	88,94	oncostatin M	TIMP-1	18413(Tax:10090)	21857(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nmod|regulation regulation|nmod|END_ENTITY	Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin_M in murine fibroblasts .
19652200	0	oncostatin_M	35,47	Thrombin	0,8	oncostatin M	Thrombin	5008	2147	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces the expression of oncostatin_M via AP-1 activation in human macrophages : a link between coagulation and inflammation .
20088942	0	oncostatin_M	26,38	angiopoietin_2	47,61	oncostatin M	angiopoietin 2	5008	285	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	The inflammatory mediator oncostatin_M induces angiopoietin_2 expression in endothelial cells in vitro and in vivo .
10205167	0	oncostatin_M	55,67	gp130	80,85	oncostatin M	gp130	18413(Tax:10090)	16195(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY requires|dobj|action requires|nmod|transducer transducer|amod|END_ENTITY	Fetal liver development requires a paracrine action of oncostatin_M through the gp130 signal transducer .
10681548	0	oncostatin_M	70,82	gp130	20,25	oncostatin M	gp130	5008	3572	Gene	Gene	response|compound|START_ENTITY involved|nmod|response involved|nsubj|Identification Identification|nmod|site site|amod|END_ENTITY	Identification of a gp130 cytokine receptor critical site involved in oncostatin_M response .
12724316	0	oncostatin_M	32,44	gp130	109,114	oncostatin M	gp130	5008	3572	Gene	Gene	signaling|nmod|START_ENTITY Desensitization|acl|signaling involves|nsubj|Desensitization involves|dobj|759 759|nmod|END_ENTITY	Desensitization of signaling by oncostatin_M in human vascular cells involves cytoplasmic Tyr residue 759 in gp130 but is not mediated by either Src homology 2 domain-containing tyrosine_phosphatase_2_or_suppressor_of_cytokine_signaling_3 .
1324910	0	oncostatin_M	47,59	gp130	32,37	oncostatin M	gp130	5008	3572	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Interleukin-6 signal transducer gp130 mediates oncostatin_M signaling .
1542794	0	oncostatin_M	38,50	gp130	28,33	oncostatin M	gp130	5008	3572	Gene	Gene	receptor|compound|START_ENTITY transducer|dep|receptor transducer|appos|END_ENTITY	The IL-6 signal transducer , gp130 : an oncostatin_M receptor and affinity converter for the LIF_receptor .
15863389	0	oncostatin_M	31,43	gp130	15,20	oncostatin M	gp130	5008	3572	Gene	Gene	cytokines|dobj|START_ENTITY cytokines|nsubj|Measurement Measurement|nmod|END_ENTITY	Measurement of gp130 cytokines oncostatin_M and IL-6 in gingival crevicular fluid of patients with chronic_periodontitis .
25103368	0	oncostatin_M	108,120	gp130	17,22	oncostatin M	gp130	5008	3572	Gene	Gene	receptor|compound|START_ENTITY lack|dobj|receptor reveals|ccomp|lack reveals|nsubj|expression expression|amod|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
25103368	0	oncostatin_M	158,170	gp130	17,22	oncostatin M	gp130	5008	3572	Gene	Gene	lack|xcomp|START_ENTITY reveals|ccomp|lack reveals|nsubj|expression expression|amod|END_ENTITY	Analysis of IL-6 / gp130 family receptor expression reveals that in contrast to astroglia , microglia lack the oncostatin_M receptor and functional responses to oncostatin_M .
8054483	0	oncostatin_M	21,33	gp130	66,71	oncostatin M	gp130	18413(Tax:10090)	16195(Tax:10090)	Gene	Gene	Interactions|nmod|START_ENTITY signal|nsubj|Interactions signal|dobj|transducer transducer|appos|END_ENTITY	Interactions between oncostatin_M and the IL-6 signal transducer , gp130 .
8580365	0	oncostatin_M	10,22	gp130	93,98	oncostatin M	gp130	289747(Tax:10116)	25205(Tax:10116)	Gene	Gene	START_ENTITY|dep|gp80 gp80|appos|END_ENTITY	Cytokines oncostatin_M and interleukin 1 regulate the expression of the IL-6 receptor -LRB- gp80 , gp130 -RRB- .
20408777	0	oncostatin_M	16,28	gp_130	32,38	oncostatin M	gp 130	5008	3572	Gene	Gene	START_ENTITY|appos|cytokine cytokine|amod|END_ENTITY	Serum levels of oncostatin_M -LRB- a gp_130 cytokine -RRB- : an inflammatory biomarker in periodontal_disease .
10671298	0	oncostatin_M	61,73	interleukin-6	97,110	oncostatin M	interleukin-6	18413(Tax:10090)	16193(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY transcripts|nmod|gene expression|nmod|transcripts expression|dep|implications implications|nmod|cytokines cytokines|amod|END_ENTITY	Regulated expression of alternate transcripts from the mouse oncostatin_M gene : implications for interleukin-6 family cytokines .
11022130	0	oncostatin_M	128,140	interleukin-6	61,74	oncostatin M	interleukin-6	5008	3569	Gene	Gene	interleukin-11|appos|START_ENTITY IL-6|appos|interleukin-11 cytokines|dep|IL-6 cytokines|amod|END_ENTITY	Relationship between circulating interleukin-10 -LRB- IL-10 -RRB- with interleukin-6 -LRB- IL-6 -RRB- type cytokines -LRB- IL-6 , interleukin-11 -LRB- IL-11 -RRB- , oncostatin_M -LRB- OSM -RRB- -RRB- and soluble interleukin-6 -LRB- IL-6 -RRB- receptor -LRB- sIL-6R -RRB- in patients with multiple_myeloma .
8559663	0	oncostatin_M	36,48	interleukin-6	22,35	oncostatin M	interleukin-6	289747(Tax:10116)	24498(Tax:10116)	Gene	Gene	element|compound|START_ENTITY Identification|dep|element Identification|nmod|END_ENTITY	Identification of the interleukin-6 / oncostatin_M response element in the rat tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- promoter .
11156550	0	oncostatin_M	90,102	interleukin_1alpha	51,69	oncostatin M	interleukin 1alpha	5008	3552	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Esculetin inhibits cartilage resorption induced by interleukin_1alpha in combination with oncostatin_M .
11171688	0	oncostatin_M	174,186	interleukin_1alpha	207,225	oncostatin M	interleukin 1alpha	319086(Tax:9913)	281250(Tax:9913)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Insulin-like_growth_factor_1 blocks collagen release and down regulates matrix_metalloproteinase-1 , _ -3 , _ -8 , _ and _ -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin_M in combination with interleukin_1alpha .
7512571	0	oncostatin_M	69,81	interleukin_6	55,68	oncostatin M	interleukin 6	5008	3569	Gene	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	Ciliary_neurotrophic_factor / leukemia_inhibitory_factor / interleukin_6 / oncostatin_M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors .
23042533	0	oncostatin_M	52,64	placenta_growth_factor	15,37	oncostatin M	placenta growth factor	5008	5228	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Enhancement of placenta_growth_factor expression by oncostatin_M in human rheumatoid_arthritis synovial fibroblasts .
9057817	0	oncostatin_M	107,119	tissue_inhibitor_of_metalloproteinase-1	33,72	oncostatin M	tissue inhibitor of metalloproteinase-1	100758591	100770193	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|cells cells|amod|END_ENTITY	Autocrine/paracrine induction of tissue_inhibitor_of_metalloproteinase-1 in Chinese_hamster ovary cells by oncostatin_M .
8559663	0	oncostatin_M	36,48	tissue_inhibitor_of_metalloproteinases-1	77,117	oncostatin M	tissue inhibitor of metalloproteinases-1	289747(Tax:10116)	116510(Tax:10116)	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|amod|END_ENTITY	Identification of the interleukin-6 / oncostatin_M response element in the rat tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- promoter .
17269136	0	oncostatin_M	11,23	vascular_endothelial_growth_factor	40,74	oncostatin M	vascular endothelial growth factor	5008	7422	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oncostatin_M on secretion of vascular_endothelial_growth_factor and reconstruction of liver-like structure by fetal liver cells in monolayer and three-dimensional cultures .
11786531	0	oncostatin_M_receptor	50,71	Janus_kinase_1	14,28	oncostatin M receptor	Janus kinase 1	9180	3716	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Novel role of Janus_kinase_1 in the regulation of oncostatin_M_receptor surface expression .
16611984	0	onzin	26,31	phospholipid_scramblase_1	102,127	onzin	phospholipid scramblase 1	51316	5359	Gene	Gene	affects|nsubj|START_ENTITY affects|nmod|END_ENTITY	The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid_scramblase_1 .
9153230	0	opaque-2	49,57	O2	59,61	opaque-2	O2	542375(Tax:4577)	542375(Tax:4577)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Analysis of the methylation pattern of the maize opaque-2 -LRB- O2 -RRB- promoter and in vitro binding studies indicate that the O2 B-Zip protein and other endosperm factors can bind to methylated target sequences .
10982458	0	opaque-2	127,135	zein	107,111	opaque-2	zein	542375(Tax:4577)	732802(Tax:4577)	Gene	Gene	endosperms|amod|START_ENTITY genes|nmod|endosperms genes|compound|END_ENTITY	Specific combinations of zein genes and genetic backgrounds influence the transcription of the heavy-chain zein genes in maize opaque-2 endosperms .
10982458	0	opaque-2	127,135	zein	25,29	opaque-2	zein	542375(Tax:4577)	732802(Tax:4577)	Gene	Gene	endosperms|amod|START_ENTITY genes|nmod|endosperms transcription|nmod|genes influence|dobj|transcription influence|nsubj|combinations combinations|nmod|genes genes|compound|END_ENTITY	Specific combinations of zein genes and genetic backgrounds influence the transcription of the heavy-chain zein genes in maize opaque-2 endosperms .
10526147	0	opioid-binding_cell_adhesion_molecule	16,53	OBCAM	55,60	opioid-binding cell adhesion molecule	OBCAM	116597(Tax:10116)	116597(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of opioid-binding_cell_adhesion_molecule -LRB- OBCAM -RRB- in adult rat brain .
10960687	0	opioid-binding_cell_adhesion_molecule	28,65	OBCAM	67,72	opioid-binding cell adhesion molecule	OBCAM	116597(Tax:10116)	116597(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of opioid-binding_cell_adhesion_molecule -LRB- OBCAM -RRB- in rat brain .
11324527	0	opioid-receptor-like_receptor	15,44	ORL1	46,50	opioid-receptor-like receptor	ORL1	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of opioid-receptor-like_receptor -LRB- ORL1 -RRB- gene in rat brain -RSB- .
11113537	0	opioid_growth_factor_receptor	51,80	OGFr	82,86	opioid growth factor receptor	OGFr	72075(Tax:10090)	72075(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization and distribution of the opioid_growth_factor_receptor -LRB- OGFr -RRB- in mouse .
11413235	0	opioid_receptor-like	17,37	ORL1	39,43	opioid receptor-like	ORL1	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Dual coupling of opioid_receptor-like -LRB- ORL1 -RRB- receptors to adenylyl cyclase in the different layers of the rat main olfactory bulb .
12472900	0	opioid_receptor-like	31,51	ORL1	53,57	opioid receptor-like	ORL1	4987	4987	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Constitutive activation of the opioid_receptor-like -LRB- ORL1 -RRB- receptor by mutation of Asn133_to_tryptophan in the third transmembrane region .
14684324	0	opioid_receptor-like	81,101	ORL1	103,107	opioid receptor-like	ORL1	4987	4987	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The design and synthesis of a novel quinolizidine_template for potent opioid and opioid_receptor-like -LRB- ORL1 , NOP -RRB- receptor ligands .
18634857	0	opioid_receptor-like	16,36	ORL1	38,42	opioid receptor-like	ORL1	18389(Tax:10090)	18389(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The role of the opioid_receptor-like -LRB- ORL1 -RRB- receptor in motor stimulatory and rewarding actions of buprenorphine and morphine .
8733732	0	opioid_receptor-like	18,38	ORL1	40,44	opioid receptor-like	ORL1	29256(Tax:10116)	29256(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Identification of opioid_receptor-like -LRB- ORL1 -RRB- peptide-stimulated -LSB- 35S -RSB- GTP gamma S binding in rat brain .
9086468	0	opioid_receptor-like1	53,74	nociceptin	38,48	opioid receptor-like1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	agonist|amod|START_ENTITY END_ENTITY|appos|agonist	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by unilateral constriction_injury_to_the_sciatic_nerve in the rat .
9134994	0	opioid_receptor-like1	53,74	nociceptin	38,48	opioid receptor-like1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	agonist|amod|START_ENTITY END_ENTITY|appos|agonist	Effects of intrathecally administered nociceptin , an opioid_receptor-like1 -LRB- ORL1 -RRB- receptor agonist , on the thermal hyperalgesia induced by carageenan injection into the rat paw .
9300417	0	opioid_receptor-like1	62,83	nociceptin	47,57	opioid receptor-like1	nociceptin	29256(Tax:10116)	25516(Tax:10116)	Gene	Gene	agonist|amod|START_ENTITY END_ENTITY|appos|agonist	Analgesic effect of intrathecally administered nociceptin , an opioid_receptor-like1 receptor agonist , in the rat formalin test .
11591451	0	opioid_receptor-like_1	32,54	ORL1	56,60	opioid receptor-like 1	ORL1	18389(Tax:10090)	18389(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Autoradiographic mapping of the opioid_receptor-like_1 -LRB- ORL1 -RRB- receptor in the brains of mu - , delta - or kappa-opioid receptor knockout mice .
15802762	0	opioid_receptor-like_1	14,36	ORL1	38,42	opioid receptor-like 1	ORL1	18389(Tax:10090)	18389(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression of opioid_receptor-like_1 -LRB- ORL1 -RRB- _ mu opioid receptors in the spinal cord of morphine tolerant mice .
19398200	0	opioid_receptor-like_1	40,62	ORL1	64,68	opioid receptor-like 1	ORL1	4987	4987	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Optimization of benzimidazole series as opioid_receptor-like_1 -LRB- ORL1 -RRB- antagonists : SAR study directed toward improvement of selectivity over hERG activity .
19447610	0	opioid_receptor-like_1	63,85	ORL1	87,91	opioid receptor-like 1	ORL1	4987	4987	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of novel arylpyrazole series as potent and selective opioid_receptor-like_1 -LRB- ORL1 -RRB- antagonists .
19041249	0	opioid_receptor_like-1	99,121	ORL1	123,127	opioid receptor like-1	ORL1	4987	4987	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery and structure-activity relationships of 4-aminoquinazoline derivatives , a novel class of opioid_receptor_like-1 -LRB- ORL1 -RRB- antagonists .
18410445	0	opiorphin	4,13	ProL1	20,25	opiorphin	ProL1	58503	58503	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The opiorphin gene -LRB- ProL1 -RRB- and its homologues function in erectile physiology .
26463133	0	opiorphin	117,126	enkephalinase	57,70	opiorphin	enkephalinase	58503	4311	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Influence of polar side chains modifications on the dual enkephalinase inhibitory activity and conformation of human opiorphin , a pain perception related peptide .
1633816	0	opn	55,58	osteopontin	60,71	opn	osteopontin	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Characterization of the promoter region of the porcine opn -LRB- osteopontin , secreted_phosphoprotein_1 -RRB- gene .
11591373	0	opsin	29,34	Ci-opsin1	0,9	opsin	Ci-opsin1	445754(Tax:7719)	445754(Tax:7719)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Ci-opsin1 , a vertebrate-type opsin gene , expressed in the larval ocellus of the ascidian Ciona_intestinalis .
3040524	0	opsin	38,43	ninaE	32,37	opsin	ninaE	42367(Tax:7227)	42367(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Analysis of the promoter of the ninaE opsin gene in Drosophila_melanogaster .
23956131	0	optineurin	20,30	NRL	65,68	optineurin	NRL	246294(Tax:10116)	290221(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between optineurin and the bZIP transcription factor NRL .
17293779	0	optineurin	13,23	OPTN	25,29	optineurin	OPTN	10133	10133	Gene	Gene	Variation|nmod|START_ENTITY Variation|appos|END_ENTITY	Variation in optineurin -LRB- OPTN -RRB- allele frequencies between and within populations .
18307994	0	optineurin	31,41	TBK1	20,24	optineurin	TBK1	10133	29110	Gene	Gene	mutant|compound|START_ENTITY Enhanced|nmod|mutant Enhanced|nmod|END_ENTITY	Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle_glaucoma .
27086836	0	optineurin	27,37	TBK1	4,8	optineurin	TBK1	71648(Tax:10090)	56480(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The TBK1 binding domain of optineurin promotes type I interferon responses .
7722915	0	oral_lichen_planus	33,51	Heat_shock_protein	0,18	heat shock protein	Heat shock protein	7190	7190	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Heat_shock_protein expression in oral_lichen_planus .
23188630	0	orc2	24,28	Plk1	0,4	orc2	Plk1	4999	5347	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic_cancer .
20803175	0	orexin-1_receptor	35,52	OX1R	54,58	orexin-1 receptor	OX1R	230777(Tax:10090)	230777(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of the orexin-1_receptor -LRB- OX1R -RRB- after traumatic_brain_injury in mice .
23907013	0	orexin_A	11,19	GLUT4	23,28	orexin A	GLUT4	25723(Tax:10116)	25139(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of orexin_A on GLUT4 expression and lipid content via MAPK signaling in 3T3-L1 adipocytes .
10598828	0	orexin_A	11,19	thyrotropin-releasing_hormone	23,52	orexin A	thyrotropin-releasing hormone	25723(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|secretion secretion|compound|END_ENTITY	Effects of orexin_A on thyrotropin-releasing_hormone and thyrotropin secretion in rats .
9696808	0	orf4	19,23	adenovirus_type_5	41,58	orf4	adenovirus type 5	83992	8081	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	The early region 4 orf4 protein of human adenovirus_type_5 induces p53-independent cell death by apoptosis .
21665049	0	organic_anion-transporting_polypeptide_1B1	10,52	OATP1B1	54,61	organic anion-transporting polypeptide 1B1	OATP1B1	10599	10599	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Effect of organic_anion-transporting_polypeptide_1B1 -LRB- OATP1B1 -RRB- polymorphism on the single - and multiple-dose pharmacokinetics of enalapril in healthy Chinese adult men .
18492796	0	organic_anion-transporting_polypeptide_1b2	19,61	Oatp1b2	63,70	organic anion-transporting polypeptide 1b2	Oatp1b2	28253(Tax:10090)	28253(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the murine organic_anion-transporting_polypeptide_1b2 -LRB- Oatp1b2 -RRB- in drug disposition and hepatotoxicity .
15483194	0	organic_anion-transporting_polypeptide_4	25,65	Oatp4	67,72	organic anion-transporting polypeptide 4	Oatp4	28253(Tax:10090)	28253(Tax:10090)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|dep|END_ENTITY	Down-regulation of mouse organic_anion-transporting_polypeptide_4 -LRB- Oatp4 ; Oatp1b2 ; Slc21a10 -RRB- mRNA by lipopolysaccharide through the toll-like_receptor_4 -LRB- TLR4 -RRB- .
16164626	0	organic_anion_transporter	72,97	OAT	99,102	organic anion transporter	OAT	4942	4942	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Analyses of coding region polymorphisms in apical and basolateral human organic_anion_transporter -LRB- OAT -RRB- genes -LSB- OAT1 -LRB- NKT -RRB- , OAT2 , OAT3 , OAT4 , URAT -LRB- RST -RRB- -RSB- .
16164626	0	organic_anion_transporter	72,97	OAT1	111,115	organic anion transporter	OAT1	4942	9356	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	Analyses of coding region polymorphisms in apical and basolateral human organic_anion_transporter -LRB- OAT -RRB- genes -LSB- OAT1 -LRB- NKT -RRB- , OAT2 , OAT3 , OAT4 , URAT -LRB- RST -RRB- -RSB- .
10964714	0	organic_anion_transporter_1	54,81	hOAT1	83,88	organic anion transporter 1	hOAT1	9356	9356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and in vivo expression of the human organic_anion_transporter_1 -LRB- hOAT1 -RRB- gene .
16325760	0	organic_anion_transporter_1	33,60	rOAT1	62,67	organic anion transporter 1	rOAT1	29509(Tax:10116)	29509(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Functional expression of the rat organic_anion_transporter_1 -LRB- rOAT1 -RRB- in Saccharomyces_cerevisiae .
15901346	0	organic_anion_transporter_2	55,82	SLC22A7	91,98	organic anion transporter 2	SLC22A7	10864	10864	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	Transport mechanism and substrate specificity of human organic_anion_transporter_2 -LRB- hOat2 -LSB- SLC22A7 -RSB- -RRB- .
15900017	0	organic_anion_transporter_2	30,57	Slc22a7	59,66	organic anion transporter 2	Slc22a7	89776(Tax:10116)	89776(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Functional involvement of rat organic_anion_transporter_2 -LRB- Slc22a7 -RRB- in the hepatic uptake of the nonsteroidal anti-inflammatory drug ketoprofen .
15901346	0	organic_anion_transporter_2	55,82	hOat2	84,89	organic anion transporter 2	hOat2	10864	10864	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|amod|END_ENTITY	Transport mechanism and substrate specificity of human organic_anion_transporter_2 -LRB- hOat2 -LSB- SLC22A7 -RSB- -RRB- .
19878671	0	organic_anion_transporter_3	42,69	Angiotensin_II	0,14	organic anion transporter 3	Angiotensin II	9376	183	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Angiotensin_II inhibits activity of human organic_anion_transporter_3 through activation of protein kinase Calpha : accelerating endocytosis of the transporter .
17719021	0	organic_anion_transporter_3	12,39	Oat3	41,45	organic anion transporter 3	Oat3	83500(Tax:10116)	83500(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of rat organic_anion_transporter_3 -LRB- Oat3 -RRB- in the renal basolateral transport of glutathione .
23615001	0	organic_anion_transporter_3	20,47	SLC22A8	49,56	organic anion transporter 3	SLC22A8	9376	9376	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of renal organic_anion_transporter_3 -LRB- SLC22A8 -RRB- expression and function by the integrity of lipid raft domains and their associated cytoskeleton .
20299424	0	organic_anion_transporter_3	20,47	bradykinin	67,77	organic anion transporter 3	bradykinin	9376	3827	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human organic_anion_transporter_3 by peptide hormone bradykinin .
17220594	0	organic_anion_transporter_3	14,41	mOat3	43,48	organic anion transporter 3	mOat3	19879(Tax:10090)	19879(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of mouse organic_anion_transporter_3 -LRB- mOat3 -RRB- as a basolateral prostaglandin_E2 transport pathway .
11961115	0	organic_anion_transporter_3	50,77	rOat3	79,84	organic anion transporter 3	rOat3	83500(Tax:10116)	83500(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Expression and functional characterization of rat organic_anion_transporter_3 -LRB- rOat3 -RRB- in the choroid_plexus .
16079298	0	organic_anion_transporter_5	35,62	Slc22a19	64,72	organic anion transporter 5	Slc22a19	286961(Tax:10116)	286961(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of rat organic_anion_transporter_5 -LRB- Slc22a19 -RRB- at the apical membrane of renal proximal tubules .
26239079	0	organic_anion_transporter_7	37,64	SLC22A9	65,72	organic anion transporter 7	SLC22A9	114571	114571	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Variability in hepatic expression of organic_anion_transporter_7 / SLC22A9 , a novel pravastatin uptake transporter : impact of genetic and regulatory factors .
23082789	0	organic_anion_transporting_polypeptide	20,58	OATP	60,64	organic anion transporting polypeptide	OATP	6579	6579	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Characterization of organic_anion_transporting_polypeptide -LRB- OATP -RRB- expression and its functional contribution to the uptake of substrates in human hepatocytes .
19285480	0	organic_anion_transporting_polypeptide	16,54	OATP2B1	55,62	organic anion transporting polypeptide	OATP2B1	6579	11309	Gene	Gene	Contribution|nmod|START_ENTITY END_ENTITY|nsubj|Contribution	Contribution of organic_anion_transporting_polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells .
16397270	0	organic_anion_transporting_polypeptide-A	80,120	steroid_and_xenobiotic_receptor	18,49	organic anion transporting polypeptide-A	steroid and xenobiotic receptor	6579	8856	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the steroid_and_xenobiotic_receptor and its possible target gene , organic_anion_transporting_polypeptide-A , in human breast_carcinoma .
24970118	0	organic_anion_transporting_polypeptide_1A2	24,66	OATP1A2	68,75	organic anion transporting polypeptide 1A2	OATP1A2	6579	6579	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Molecular regulation of organic_anion_transporting_polypeptide_1A2 -LRB- OATP1A2 -RRB- by taurocholic_acid in Bewo Cells .
25418376	0	organic_anion_transporting_polypeptide_1B1	18,60	OATP1B1	62,69	organic anion transporting polypeptide 1B1	OATP1B1	10599	10599	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role of organic_anion_transporting_polypeptide_1B1 -LRB- OATP1B1 -RRB- in the selective hepatic uptake of hematoporphyrin_monomethyl_ether isomers .
16758257	0	organic_anion_transporting_polypeptide_1B1	65,107	SLCO1B1	108,115	organic anion transporting polypeptide 1B1	SLCO1B1	10599	10599	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Frequencies of single nucleotide polymorphisms and haplotypes of organic_anion_transporting_polypeptide_1B1 SLCO1B1 gene in a Finnish population .
15255953	0	organic_anion_transporting_polypeptide_3	16,56	oatp3	58,63	organic anion transporting polypeptide 3	oatp3	108096(Tax:10090)	108096(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of organic_anion_transporting_polypeptide_3 -LRB- oatp3 -RRB- in mouse brain parenchymal and capillary endothelial cells .
14739090	0	organic_anion_transporting_polypeptide_8	10,50	SLCO1B3	52,59	organic anion transporting polypeptide 8	SLCO1B3	28234	28234	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human organic_anion_transporting_polypeptide_8 -LRB- SLCO1B3 -RRB- gene is transcriptionally repressed by hepatocyte_nuclear_factor_3beta in hepatocellular_carcinoma .
12566240	0	organic_anion_transporting_polypeptide_E	14,54	OATP-E	56,62	organic anion transporting polypeptide E	OATP-E	28231	28231	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of organic_anion_transporting_polypeptide_E -LRB- OATP-E -RRB- in human placenta .
22014179	0	organic_cation_transporter-2	74,102	y-butyrobetaine_hydroxylase	36,63	organic cation transporter-2	y-butyrobetaine hydroxylase	29503(Tax:10116)	64564(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The effects of exercise training on y-butyrobetaine_hydroxylase and novel organic_cation_transporter-2 gene expression in the rat .
10697966	0	organic_cation_transporter-like_2-antisense	76,119	ORCTL2S	121,128	organic cation transporter-like 2-antisense	ORCTL2S	5003	5003	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel single nucleotide polymorphism -LRB- SNP -RRB- in the human organic_cation_transporter-like_2-antisense -LRB- ORCTL2S -RRB- gene .
24399729	0	organic_cation_transporter_1	34,62	Glucocorticoid_receptor	0,23	organic cation transporter 1	Glucocorticoid receptor	6580	2908	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Glucocorticoid_receptor regulates organic_cation_transporter_1 -LRB- OCT1 , SLC22A1 -RRB- expression via HNF4a upregulation in primary human hepatocytes .
23922447	0	organic_cation_transporter_1	60,88	Hepatocyte_nuclear_factor_1	0,27	organic cation transporter 1	Hepatocyte nuclear factor 1	6580	6927	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hepatocyte_nuclear_factor_1 regulates the expression of the organic_cation_transporter_1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene .
24399729	0	organic_cation_transporter_1	34,62	OCT1	64,68	organic cation transporter 1	OCT1	6580	6580	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucocorticoid_receptor regulates organic_cation_transporter_1 -LRB- OCT1 , SLC22A1 -RRB- expression via HNF4a upregulation in primary human hepatocytes .
15499200	0	organic_cation_transporter_1	79,107	SLC22A1	57,64	organic cation transporter 1	SLC22A1	6580	6580	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic_cation_transporter_1 -LRB- OCT1 -RRB- .
26920453	0	organic_cation_transporter_1	39,67	pregnane_X_receptor	4,23	organic cation transporter 1	pregnane X receptor	6580	8856	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	The pregnane_X_receptor down-regulates organic_cation_transporter_1 -LRB- SLC22A1 -RRB- in human hepatocytes by squelching SRC-1 coactivator .
10051314	0	organic_cation_transporter_2	21,49	Slc22a2	56,63	organic cation transporter 2	Slc22a2	20518(Tax:10090)	20518(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the mouse organic_cation_transporter_2 gene , Slc22a2 , from an enhancer-trap transgene integration locus .
18230276	0	organic_cation_transporter_2	30,58	rOct2	60,65	organic cation transporter 2	rOct2	29503(Tax:10116)	29503(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	Functional involvement of the organic_cation_transporter_2 -LRB- rOct2 -RRB- in the renal uptake of organic cations in rats .
18710896	0	organic_cation_transporter_3	16,44	SLC22A3	46,53	organic cation transporter 3	SLC22A3	100049579	6581	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Significance of organic_cation_transporter_3 -LRB- SLC22A3 -RRB- expression for the cytotoxic effect of oxaliplatin in colorectal_cancer .
22342816	0	organic_cation_transporter_3	14,42	SLC22A3	44,51	organic cation transporter 3	SLC22A3	100049579	6581	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of organic_cation_transporter_3 -LRB- SLC22A3 -RRB- inhibition as a potential mechanism of antidepressant action .
21641380	0	organic_cation_transporter_novel_type_2	32,71	OCTN2	73,78	organic cation transporter novel type 2	OCTN2	6584	6584	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Selective regulation of cardiac organic_cation_transporter_novel_type_2 -LRB- OCTN2 -RRB- in dilated_cardiomyopathy .
25606452	0	organic_solute_carrier_protein_1	34,66	hOSCP1	68,74	organic solute carrier protein 1	hOSCP1	127700	127700	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphism of the human organic_solute_carrier_protein_1 -LRB- hOSCP1 -RRB- gene in Japanese patients with non-viral_liver_carcinoma .
17177110	0	organic_solute_transporter_alpha	31,63	LXR_alpha	0,9	organic solute transporter alpha	LXR alpha	106407(Tax:10090)	22259(Tax:10090)	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	LXR_alpha transactivates mouse organic_solute_transporter_alpha and beta via IR-1 elements shared with FXR .
11379876	0	origin_recognition_complex_subunit_5	25,61	ORC5L	63,68	origin recognition complex subunit 5	ORC5L	5001	5001	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the origin_recognition_complex_subunit_5 -LRB- ORC5L -RRB- gene in adult patients with myeloid_leukemias exhibiting deletions of chromosome band 7q22 .
8495798	0	ornithine-delta-aminotransferase	25,57	OAT	59,62	ornithine-delta-aminotransferase	OAT	4942	4942	Gene	Gene	control|nmod|START_ENTITY control|appos|END_ENTITY	Translational control of ornithine-delta-aminotransferase -LRB- OAT -RRB- by estrogen .
1635292	0	ornithine_aminotransferase	20,46	OAT	48,51	ornithine aminotransferase	OAT	4942	4942	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human ornithine_aminotransferase -LRB- OAT -RRB- in OAT-deficient Chinese_hamster_ovary cells and fibroblasts of gyrate atrophy patient .
7707692	0	ornithine_aminotransferase	69,95	ornithine_carbamoyltransferase	131,161	ornithine aminotransferase	ornithine carbamoyltransferase	18242(Tax:10090)	5009	Gene	Gene	START_ENTITY|nmod|mice mice|nmod|END_ENTITY	Decreased_hyperammonaemia and orotic_aciduria due to inactivation of ornithine_aminotransferase in mice with a hereditary abnormal ornithine_carbamoyltransferase .
7474892	0	ornithine_carbamoyltransferase	52,82	OCT	84,87	ornithine carbamoyltransferase	OCT	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of two new aberrant splicings in the ornithine_carbamoyltransferase -LRB- OCT -RRB- gene in two patients with early and late onset OCT_deficiency .
7707692	0	ornithine_carbamoyltransferase	131,161	ornithine_aminotransferase	69,95	ornithine carbamoyltransferase	ornithine aminotransferase	5009	18242(Tax:10090)	Gene	Gene	mice|nmod|START_ENTITY END_ENTITY|nmod|mice	Decreased_hyperammonaemia and orotic_aciduria due to inactivation of ornithine_aminotransferase in mice with a hereditary abnormal ornithine_carbamoyltransferase .
3109985	0	ornithine_decarboxylase	53,76	Epidermal_growth_factor	0,23	ornithine decarboxylase	Epidermal growth factor	4953	1950	Gene	Gene	activity|amod|START_ENTITY induction|nmod|activity potentiates|dobj|induction potentiates|nsubj|END_ENTITY	Epidermal_growth_factor potentiates the induction of ornithine_decarboxylase activity by prostaglandins in embryonic_palate mesenchymal cells : effects on cell proliferation and glycosaminoglycan synthesis .
6197492	0	ornithine_decarboxylase	35,58	Epidermal_growth_factor	0,23	ornithine decarboxylase	Epidermal growth factor	4953	1950	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates ornithine_decarboxylase activity in cultured mammalian keratinocytes .
6265908	0	ornithine_decarboxylase	39,62	Epidermal_growth_factor	0,23	ornithine decarboxylase	Epidermal growth factor	4953	1950	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity stimulation|amod|END_ENTITY	Epidermal_growth_factor stimulation of ornithine_decarboxylase activity in a human hepatoma cell line .
8162329	0	ornithine_decarboxylase	32,55	Epidermal_growth_factor	0,23	ornithine decarboxylase	Epidermal growth factor	4953	1950	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Epidermal_growth_factor induces ornithine_decarboxylase in SV40-immortalized human keratinocytes .
8190004	0	ornithine_decarboxylase	55,78	Epidermal_growth_factor	0,23	ornithine decarboxylase	Epidermal growth factor	4953	1950	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Epidermal_growth_factor induces biphasic activation of ornithine_decarboxylase in human stomach-derived KATO-III cells .
9619831	0	ornithine_decarboxylase	89,112	Gastrin	0,7	ornithine decarboxylase	Gastrin	4953	2520	Gene	Gene	mRNA|amod|START_ENTITY phosphorylation|nmod|mRNA induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Gastrin induces phosphorylation of eIF4E_binding_protein_1 and translation initiation of ornithine_decarboxylase mRNA .
2601687	0	ornithine_decarboxylase	65,88	H-7	0,3	ornithine decarboxylase	H-7	18263(Tax:10090)	109742(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	H-7 , a protein kinase C inhibitor , inhibits phorbol_ester-caused ornithine_decarboxylase induction but fails to inhibit phorbol_ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells .
1993840	0	ornithine_decarboxylase	13,36	IL-1	0,4	ornithine decarboxylase	IL-1	4953	3552	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	IL-1 induces ornithine_decarboxylase in normal T lymphocytes .
2971724	0	ornithine_decarboxylase	8,31	IL-1	68,72	ornithine decarboxylase	IL-1	4953	3552	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|factor factor|compound|END_ENTITY	Role of ornithine_decarboxylase in the regulation of cell growth by IL-1 and tumor necrosis factor .
3501508	0	ornithine_decarboxylase	92,115	IL-1	38,42	ornithine decarboxylase	IL-1	18263(Tax:10090)	111343(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY using|dobj|induction vivo|acl|using organs|nmod|vivo organs|nsubj|Identification Identification|nmod|sensitive sensitive|appos|END_ENTITY	Identification of some interleukin-1 -LRB- IL-1 -RRB- sensitive organs in vivo using the induction of ornithine_decarboxylase -LRB- ODC -RRB- following injection of recombinant IL-1_beta in mice .
2840461	0	ornithine_decarboxylase	14,37	IL-2	50,54	ornithine decarboxylase	IL-2	18263(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of ornithine_decarboxylase activity by IL-2 and cyclic_AMP .
1989989	0	ornithine_decarboxylase	21,44	Insulin	0,7	ornithine decarboxylase	Insulin	4953	3630	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Insulin induction of ornithine_decarboxylase .
10623442	0	ornithine_decarboxylase	26,49	Interleukin-1beta	0,17	ornithine decarboxylase	Interleukin-1beta	24609(Tax:10116)	24494(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Interleukin-1beta induces ornithine_decarboxylase activity in insulin-producing cells .
2783911	0	ornithine_decarboxylase	40,63	Interleukin-2	0,13	ornithine decarboxylase	Interleukin-2	18263(Tax:10090)	16183(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Interleukin-2 regulates the activity of ornithine_decarboxylase in a cloned murine T lymphocytic cell line : evidence for a protein_kinase_C-dependent pathway .
14506228	0	ornithine_decarboxylase	44,67	Methylthioadenosine_phosphorylase	0,33	ornithine decarboxylase	Methylthioadenosine phosphorylase	4953	4507	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Methylthioadenosine_phosphorylase regulates ornithine_decarboxylase by production of downstream metabolites .
10792465	0	ornithine_decarboxylase	55,78	OAZ-t	89,94	ornithine decarboxylase	OAZ-t	4953	51686	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of testis specific ornithine_decarboxylase antizyme -LRB- OAZ-t -RRB- gene : expression in haploid germ cells and polyamine-induced frameshifting .
11149424	0	ornithine_decarboxylase	130,153	ODC	155,158	ornithine decarboxylase	ODC	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Retinoic_acid -LRB- RA -RRB- receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine_decarboxylase -LRB- ODC -RRB- activity by retinoids : a potential role for trans-RA-induced ZBP-89 in ODC inhibition .
1573975	0	ornithine_decarboxylase	18,41	ODC	43,46	ornithine decarboxylase	ODC	4953	4953	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Polyamine levels , ornithine_decarboxylase -LRB- ODC -RRB- activity , and ODC-mRNA expression in normal and cancerous human colonocytes .
19076071	0	ornithine_decarboxylase	41,64	ODC	66,69	ornithine decarboxylase	ODC	4953	4953	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Antizyme_3 inhibits polyamine uptake and ornithine_decarboxylase -LRB- ODC -RRB- activity , but does not stimulate ODC degradation .
19440938	0	ornithine_decarboxylase	48,71	ODC	73,76	ornithine decarboxylase	ODC	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of exposure to DAMPS and GSM signals on ornithine_decarboxylase -LRB- ODC -RRB- activity : I. L-929 mouse fibroblasts .
19440939	0	ornithine_decarboxylase	48,71	ODC	73,76	ornithine decarboxylase	ODC	4953	4953	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of exposure to DAMPS and GSM signals on ornithine_decarboxylase -LRB- ODC -RRB- activity : II .
2304344	0	ornithine_decarboxylase	50,73	ODC	75,78	ornithine decarboxylase	ODC	4953	4953	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Absence of effect of supplemental oral calcium on ornithine_decarboxylase -LRB- ODC -RRB- activity in colonic mucosae of healthy individuals with a family history of colorectal_cancer .
7537363	0	ornithine_decarboxylase	39,62	ODC	64,67	ornithine decarboxylase	ODC	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcription elongation of the murine ornithine_decarboxylase -LRB- ODC -RRB- gene is regulated in vitro at two downstream elements by different attenuation mechanisms .
7543894	0	ornithine_decarboxylase	16,39	ODC	41,44	ornithine decarboxylase	ODC	24609(Tax:10116)	24609(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of ornithine_decarboxylase -LRB- ODC -RRB- in the cochlea of the immature rat .
7591239	0	ornithine_decarboxylase	29,52	ODC	54,57	ornithine decarboxylase	ODC	18263(Tax:10090)	18263(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Life-long over-expression of ornithine_decarboxylase -LRB- ODC -RRB- gene in transgenic_mice does not lead to generally enhanced tumorigenesis or neuronal_degeneration .
9162900	0	ornithine_decarboxylase	104,127	ODC	129,132	ornithine decarboxylase	ODC	24609(Tax:10116)	24609(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine_decarboxylase -LRB- ODC -RRB- gene .
964206	0	ornithine_decarboxylase	21,44	ODC	46,49	ornithine decarboxylase	ODC	24609(Tax:10116)	24609(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of uterine ornithine_decarboxylase -LRB- ODC -RRB- by antiestrogens .
3156383	0	ornithine_decarboxylase	25,48	Prolactin	0,9	ornithine decarboxylase	Prolactin	18263(Tax:10090)	19109(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity stimulation|compound|END_ENTITY	Prolactin stimulation of ornithine_decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol_myristate_acetate -LRB- TPA -RRB- , a protein kinase C activator , stimulates ornithine_decarboxylase -LRB- ODC -RRB- activity in mammary gland explants derived from 12-14 day pregnant mice .
3582728	0	ornithine_decarboxylase	33,56	Prolactin	0,9	ornithine decarboxylase	Prolactin	24609(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Prolactin selectively stimulates ornithine_decarboxylase in the lateral lobe of the rat prostate .
7876196	0	ornithine_decarboxylase	18,41	Sp1	95,98	ornithine decarboxylase	Sp1	24609(Tax:10116)	24790(Tax:10116)	Gene	Gene	START_ENTITY|nmod|binding binding|nmod|END_ENTITY	Regulation of rat ornithine_decarboxylase promoter activity by binding of transcription factor Sp1 .
7770629	0	ornithine_decarboxylase	55,78	TGF_alpha	95,104	ornithine decarboxylase	TGF alpha	24609(Tax:10116)	24827(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acid secretory response and induction of ornithine_decarboxylase and its mRNA by TGF_alpha and EGF in isolated rat gastric glands .
1874802	0	ornithine_decarboxylase	33,56	Tumor_necrosis_factor	0,21	ornithine decarboxylase	Tumor necrosis factor	4953	7124	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Tumor_necrosis_factor stimulates ornithine_decarboxylase activity in human fibroblasts and tumor target cells .
8604351	0	ornithine_decarboxylase	14,37	WT1	85,88	ornithine decarboxylase	WT1	4953	7490	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of ornithine_decarboxylase gene expression by the Wilms ' _ tumor suppressor WT1 .
15385572	0	ornithine_decarboxylase	30,53	antizyme-1	82,92	ornithine decarboxylase	antizyme-1	4953	4946	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|dep|localization	Intracellular localization of ornithine_decarboxylase and its regulatory protein , antizyme-1 .
19756694	0	ornithine_decarboxylase	57,80	antizyme_inhibitor_2	19,39	ornithine decarboxylase	antizyme inhibitor 2	4953	113451	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	High expression of antizyme_inhibitor_2 , an activator of ornithine_decarboxylase in steroidogenic cells of human gonads .
1280364	0	ornithine_decarboxylase	44,67	basic_fibroblast_growth_factor	10,40	ornithine decarboxylase	basic fibroblast growth factor	24609(Tax:10116)	54250(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of basic_fibroblast_growth_factor on ornithine_decarboxylase activity and mRNA expression in a pancreatic tumoral cell line -LRB- AR4-2J -RRB- .
11306486	0	ornithine_decarboxylase	18,41	c-MYC	72,77	ornithine decarboxylase	c-MYC	4953	4609	Gene	Gene	Use|nmod|START_ENTITY promoter|nsubj|Use promoter|xcomp|achieve achieve|dobj|expression expression|amod|END_ENTITY	Use of a modified ornithine_decarboxylase promoter to achieve efficient c-MYC - or N-MYC-regulated protein expression .
12435808	0	ornithine_decarboxylase	43,66	c-Myc	0,5	ornithine decarboxylase	c-Myc	4953	4609	Gene	Gene	exerts|nmod|START_ENTITY exerts|nsubj|END_ENTITY	c-Myc exerts a protective function through ornithine_decarboxylase against cellular insults .
12565711	0	ornithine_decarboxylase	34,57	c-Myc	132,137	ornithine decarboxylase	c-Myc	4953	4609	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|acl|interacting interacting|advcl|END_ENTITY	Transcriptional regulation of the ornithine_decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc .
8262968	0	ornithine_decarboxylase	20,43	c-Myc	62,67	ornithine decarboxylase	c-Myc	4953	4609	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of human ornithine_decarboxylase expression by the c-Myc .
8297793	0	ornithine_decarboxylase	45,68	c-Myc	0,5	ornithine decarboxylase	c-Myc	4953	4609	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	c-Myc induces the expression and activity of ornithine_decarboxylase .
8356088	0	ornithine_decarboxylase	4,27	c-Myc	64,69	ornithine decarboxylase	c-Myc	4953	4609	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	The ornithine_decarboxylase gene is a transcriptional target of c-Myc .
10072196	0	ornithine_decarboxylase	73,96	c-myc	15,20	ornithine decarboxylase	c-myc	24609(Tax:10116)	24577(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Involvement of c-myc and max in CNS beta-endorphin modulation of hepatic ornithine_decarboxylase responsiveness to insulin in rat pups .
11598794	0	ornithine_decarboxylase	127,150	c-myc	19,24	ornithine decarboxylase	c-myc	4953	4609	Gene	Gene	role|nmod|START_ENTITY protects|parataxis|role protects|nsubj|Down-modulation Down-modulation|nmod|expression expression|amod|END_ENTITY	Down-modulation of c-myc expression by phorbol_ester protects CEM T leukaemia cells from starvation-induced apoptosis : role of ornithine_decarboxylase and polyamines .
8551363	0	ornithine_decarboxylase	52,75	c-myc	118,123	ornithine decarboxylase	c-myc	24609(Tax:10116)	24577(Tax:10116)	Gene	Gene	START_ENTITY|nmod|downregulation downregulation|nmod|END_ENTITY	Neonatal deprivation of maternal touch may suppress ornithine_decarboxylase via downregulation of the proto-oncogenes c-myc and max .
15386340	0	ornithine_decarboxylase	210,233	cyclooxygenase-2	192,208	ornithine decarboxylase	cyclooxygenase-2	18263(Tax:10090)	19225(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Development of a chemoresistant orthotopic human nonsmall_cell_lung_carcinoma model in nude_mice : analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2 , ornithine_decarboxylase , lung-related resistance protein , prostaglandin_E synthetase , and glutathione-S-transferase-alpha -LRB- GST -RRB- - alpha , GST-mu , and GST-pi .
2045675	0	ornithine_decarboxylase	42,65	cyclosporine_A	24,38	ornithine decarboxylase	cyclosporine A	18263(Tax:10090)	71991(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Differential effects of cyclosporine_A on ornithine_decarboxylase activity induced by ultraviolet-B and PUVA in mouse skin .
1611658	0	ornithine_decarboxylase	37,60	epidermal_growth_factor	10,33	ornithine decarboxylase	epidermal growth factor	24609(Tax:10116)	25313(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on ornithine_decarboxylase activity and urea synthesis in isolated rat hepatocytes .
2495753	0	ornithine_decarboxylase	37,60	epidermal_growth_factor	10,33	ornithine decarboxylase	epidermal growth factor	4953	1950	Gene	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of epidermal_growth_factor on ornithine_decarboxylase activity in A431 cells .
8353159	0	ornithine_decarboxylase	38,61	epidermal_growth_factor	11,34	ornithine decarboxylase	epidermal growth factor	24609(Tax:10116)	25313(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY Effects|nmod|activity Effects|nmod|END_ENTITY	Effects of epidermal_growth_factor on ornithine_decarboxylase activity and DNA synthesis in rats during the perinatal period .
8912706	0	ornithine_decarboxylase	121,144	epidermal_growth_factor	41,64	ornithine decarboxylase	epidermal growth factor	4953	1950	Gene	Gene	activity|compound|START_ENTITY leading|nmod|activity inhibits|advcl|leading inhibits|dobj|signalling signalling|compound|END_ENTITY	Phorbol_12-myristate_13-acetate inhibits epidermal_growth_factor signalling in human keratinocytes , leading to decreased ornithine_decarboxylase activity .
22976807	0	ornithine_decarboxylase	8,31	estrogen_receptor_alpha	49,72	ornithine decarboxylase	estrogen receptor alpha	4953	2099	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Role of ornithine_decarboxylase in regulation of estrogen_receptor_alpha expression and growth in human breast_cancer cells .
1997467	0	ornithine_decarboxylase	136,159	gastrin	13,20	ornithine decarboxylase	gastrin	4953	2520	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of gastrin , gastrin_receptor blockers , epidermal_growth_factor , and difluoromethylornithine on the growth and the activity of ornithine_decarboxylase of colonic_carcinoma cells .
2409817	0	ornithine_decarboxylase	63,86	gastrin	35,42	ornithine decarboxylase	gastrin	24609(Tax:10116)	25320(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Attenuation of trophic response to gastrin after inhibition of ornithine_decarboxylase .
3138918	0	ornithine_decarboxylase	16,39	gastrin	73,80	ornithine decarboxylase	gastrin	24609(Tax:10116)	25320(Tax:10116)	Gene	Gene	START_ENTITY|dep|localization localization|nmod|END_ENTITY	Gastric mucosal ornithine_decarboxylase : localization and stimulation by gastrin .
8074227	0	ornithine_decarboxylase	31,54	gastrin	67,74	ornithine decarboxylase	gastrin	24609(Tax:10116)	25320(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY induction|nmod|activity inhibits|dobj|induction inhibits|nmod|END_ENTITY	Secretin inhibits induction of ornithine_decarboxylase activity by gastrin in duodenal mucosa and IEC-6 cells .
2051998	0	ornithine_decarboxylase	30,53	insulin	14,21	ornithine decarboxylase	insulin	4953	3630	Gene	Gene	induced|dobj|START_ENTITY induced|nsubj|Modulation Modulation|nmod|END_ENTITY	Modulation of insulin induced ornithine_decarboxylase by putrescine and methylputrescines in H-35 hepatoma cells .
7009787	0	ornithine_decarboxylase	63,86	insulin	11,18	ornithine decarboxylase	insulin	24609(Tax:10116)	280829(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity Effects|dep|stimulation Effects|nmod|END_ENTITY	Effects of insulin on cultured rat brain cells : stimulation of ornithine_decarboxylase activity .
8397882	0	ornithine_decarboxylase	74,97	insulin	16,23	ornithine decarboxylase	insulin	4953	3630	Gene	Gene	activity|compound|START_ENTITY expression|nmod|activity suppresses|dobj|expression suppresses|nsubj|resistance resistance|compound|END_ENTITY	Ethanol-induced insulin resistance suppresses the expression of embryonic ornithine_decarboxylase activity .
7578852	0	ornithine_decarboxylase	14,37	lpr	80,83	ornithine decarboxylase	lpr	18263(Tax:10090)	14102(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of ornithine_decarboxylase in the kidney of autoimmune mice with the lpr gene .
1333875	0	ornithine_decarboxylase	14,37	parathyroid_hormone	41,60	ornithine decarboxylase	parathyroid hormone	24609(Tax:10116)	24694(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of ornithine_decarboxylase by parathyroid_hormone in osteoblastic cell systems .
1654784	0	ornithine_decarboxylase	34,57	parathyroid_hormone	11,30	ornithine decarboxylase	parathyroid hormone	4953	5741	Gene	Gene	activity|amod|START_ENTITY Effects|nmod|activity Effects|nmod|END_ENTITY	Effects of parathyroid_hormone on ornithine_decarboxylase activity in human osteosarcoma cells .
1482216	0	ornithine_decarboxylase	29,52	prolactin	16,25	ornithine decarboxylase	prolactin	24609(Tax:10116)	24683(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Acute effect of prolactin on ornithine_decarboxylase activity in the rat testis .
6145646	0	ornithine_decarboxylase	45,68	prolactin	22,31	ornithine decarboxylase	prolactin	24609(Tax:10116)	24683(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Cyclosporine inhibits prolactin induction of ornithine_decarboxylase in rat tissues .
6195664	0	ornithine_decarboxylase	29,52	prolactin	109,118	ornithine decarboxylase	prolactin	4953	5617	Gene	Gene	activity|amod|START_ENTITY prolactin|nmod|activity action|nmod|prolactin essential|nsubj|action essential|nmod|actions actions|nmod|END_ENTITY	Early action of prolactin on ornithine_decarboxylase activity is not essential for the subsequent actions of prolactin on casein and lipid biosynthesis .
6195664	0	ornithine_decarboxylase	29,52	prolactin	16,25	ornithine decarboxylase	prolactin	4953	5617	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Early action of prolactin on ornithine_decarboxylase activity is not essential for the subsequent actions of prolactin on casein and lipid biosynthesis .
8355506	0	ornithine_decarboxylase	88,111	prolactin	169,178	ornithine decarboxylase	prolactin	4953	5617	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	Human promyelocytic cell line HL60 has the specific binding sites for prolactin and its ornithine_decarboxylase , DNA synthesis and cellular proliferation are induced by prolactin .
3418748	0	ornithine_decarboxylase_antizyme	24,56	ODC-AZ	58,64	ornithine decarboxylase antizyme	ODC-AZ	25502(Tax:10116)	25502(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Chloroform induction of ornithine_decarboxylase_antizyme -LRB- ODC-AZ -RRB- in male rat liver .
11994307	1	ornithine_transcarbamylase	137,163	HNF4alpha	117,126	ornithine transcarbamylase	HNF4alpha	18416(Tax:10090)	15378(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	HNF4alpha regulates ornithine_transcarbamylase in vivo .
12402347	0	ornithine_transcarbamylase	57,83	OTC	85,88	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	H intragenic polymorphisms and haplotype analysis in the ornithine_transcarbamylase -LRB- OTC -RRB- gene and their relevance for tracking the inheritance of OTC_deficiency .
16786505	0	ornithine_transcarbamylase	41,67	OTC	69,72	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations and polymorphisms in the human ornithine_transcarbamylase -LRB- OTC -RRB- gene .
17041896	0	ornithine_transcarbamylase	47,73	OTC	75,78	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of novel mutations in the human ornithine_transcarbamylase -LRB- OTC -RRB- gene of Korean patients with OTC_deficiency and transient expression of the mutant proteins in vitro .
17044854	0	ornithine_transcarbamylase	63,89	OTC	96,99	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational spectrum and linkage disequilibrium patterns at the ornithine_transcarbamylase gene -LRB- OTC -RRB- .
18204299	0	ornithine_transcarbamylase	25,51	OTC	53,56	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the ornithine_transcarbamylase -LRB- OTC -RRB- gene in five Japanese OTC_deficiency patients revealed two known and three novel mutations including a deep intronic mutation .
19475717	0	ornithine_transcarbamylase	59,85	OTC	87,90	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular mechanisms underlying large genomic deletions in ornithine_transcarbamylase -LRB- OTC -RRB- gene .
7999674	0	ornithine_transcarbamylase	108,134	OTC	136,139	ornithine transcarbamylase	OTC	25611(Tax:10116)	25611(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Normalization of hair growth in sparse fur-abnormal skin and hair -LRB- SPF-ASH -RRB- mice by introduction of the rat ornithine_transcarbamylase -LRB- OTC -RRB- gene .
8019156	0	ornithine_transcarbamylase	27,53	OTC	55,58	ornithine transcarbamylase	OTC	25611(Tax:10116)	25611(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Effects of zinc on hepatic ornithine_transcarbamylase -LRB- OTC -RRB- activity .
8830175	0	ornithine_transcarbamylase	39,65	OTC	67,70	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of new mutations in the ornithine_transcarbamylase -LRB- OTC -RRB- gene in Korean families .
9286441	0	ornithine_transcarbamylase	4,30	OTC	32,35	ornithine transcarbamylase	OTC	5009	5009	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The ornithine_transcarbamylase -LRB- OTC -RRB- gene : mutations in 50 Japanese families with OTC_deficiency .
11265402	0	orotate_phosphoribosyl_transferase	45,79	OPRT	90,94	orotate phosphoribosyl transferase	OPRT	7372	7372	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Expression and pathophysiologic features of orotate_phosphoribosyl_transferase activity -LRB- OPRT -RRB- in gastric_carcinoma -RSB- .
17607371	0	orotate_phosphoribosyltransferase	14,47	OPRT	49,53	orotate phosphoribosyltransferase	OPRT	7372	7372	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of orotate_phosphoribosyltransferase -LRB- OPRT -RRB- in hepatobiliary_and_pancreatic_carcinoma .
19020767	0	orotate_phosphoribosyltransferase	55,88	dihydropyrimidine_dehydrogenase	22,53	orotate phosphoribosyltransferase	dihydropyrimidine dehydrogenase	7372	1806	Gene	Gene	START_ENTITY|nsubj|synthase synthase|appos|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , orotate_phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis .
21791367	0	orotate_phosphoribosyltransferase	80,113	dihydropyrimidine_dehydrogenase	22,53	orotate phosphoribosyltransferase	dihydropyrimidine dehydrogenase	7372	1806	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
21791367	0	orotate_phosphoribosyltransferase	80,113	thymidine_phosphorylase	55,78	orotate phosphoribosyltransferase	thymidine phosphorylase	7372	1890	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
22577560	0	orphan_nuclear_receptor	27,50	small_heterodimer_partner	51,76	orphan nuclear receptor	small heterodimer partner	2103	8431	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	A pleiotropic role for the orphan_nuclear_receptor small_heterodimer_partner in lipid homeostasis and metabolic pathways .
14627819	0	orphan_nuclear_receptor_SHP	36,63	E2A	112,115	orphan nuclear receptor SHP	E2A	8431	6929	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nmod|END_ENTITY	Synergistic activation of the human orphan_nuclear_receptor_SHP gene promoter by basic helix-loop-helix protein E2A and orphan nuclear receptor SF-1 .
11179691	0	orphan_receptor	86,101	cholesterol_7alpha-hydroxylase	14,44	orphan receptor	cholesterol 7alpha-hydroxylase	259241(Tax:10116)	25428(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of cholesterol_7alpha-hydroxylase gene -LRB- CYP7A1 -RRB- transcription by the liver orphan_receptor -LRB- LXRalpha -RRB- .
8930965	0	orphanin_FQ	70,81	Nociceptin	0,10	orphanin FQ	Nociceptin	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Nociceptin or antinociceptin : potent spinal antinociceptive effect of orphanin_FQ / nociceptin in the rat .
11006485	1	orphanin_FQ	136,147	OFQ	149,152	orphanin FQ	OFQ	5368	5368	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	_ 5 -RSB- decan-4-one , a potent and selective orphanin_FQ -LRB- OFQ -RRB- receptor agonist with anxiolytic-like properties .
10464356	0	orphanin_FQ	151,162	ORL1	22,26	orphanin FQ	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	distribution|dep|START_ENTITY receptor|dep|distribution receptor|appos|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor distribution in the rat central nervous system : comparison of ORL1 receptor mRNA expression with -LRB- 125 -RRB- I - -LSB- -LRB- 14 -RRB- Tyr -RSB- - orphanin_FQ binding .
10464356	0	orphanin_FQ	151,162	ORL1	99,103	orphanin FQ	ORL1	25516(Tax:10116)	29256(Tax:10116)	Gene	Gene	distribution|dep|START_ENTITY distribution|dep|comparison comparison|nmod|expression expression|compound|END_ENTITY	Opioid_receptor-like -LRB- ORL1 -RRB- receptor distribution in the rat central nervous system : comparison of ORL1 receptor mRNA expression with -LRB- 125 -RRB- I - -LSB- -LRB- 14 -RRB- Tyr -RSB- - orphanin_FQ binding .
10758169	0	orphanin_FQ	27,38	ORL1	59,63	orphanin FQ	ORL1	25516(Tax:10116)	4987	Gene	Gene	agonist|nmod|START_ENTITY agonist|dep|END_ENTITY	A synthetic agonist at the orphanin_FQ / nociceptin receptor ORL1 : anxiolytic profile in the rat .
11719021	0	orphanin_FQ	14,25	ORL1	56,60	orphanin FQ	ORL1	5368	4987	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of orphanin_FQ and the opioid_receptor-like -LRB- ORL1 -RRB- receptor in the developing human and rat brain .
9869608	0	orphanin_FQ	60,71	neuropeptide	46,58	orphanin FQ	neuropeptide	25516(Tax:10116)	379044(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|significance significance|nmod|END_ENTITY	Functional significance of a newly discovered neuropeptide , orphanin_FQ , in rat gastrointestinal motility .
14757141	0	orphanin_FQ	20,31	nociceptin	32,42	orphanin FQ	nociceptin	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|dep|END_ENTITY	Tonic inhibition by orphanin_FQ / nociceptin of noradrenaline neurotransmission in the amygdala .
24155687	0	orphanin_FQ	12,23	nociceptin	24,34	orphanin FQ	nociceptin	5368	5368	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of orphanin_FQ / nociceptin in neuroplasticity : relationship to stress , anxiety and neuroinflammation .
9455999	0	orphanin_FQ	24,35	nociceptin	12,22	orphanin FQ	nociceptin	25516(Tax:10116)	25516(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Presence of nociceptin -LRB- orphanin_FQ -RRB- receptors in rat retina : comparison with receptors in striatum .
9706692	0	orthodenticle	30,43	runt	15,19	orthodenticle	runt	31802(Tax:7227)	33059(Tax:7227)	Gene	Gene	expression|amod|START_ENTITY restricts|dobj|expression restricts|nsubj|END_ENTITY	Pair-rule gene runt restricts orthodenticle expression to the presumptive head of the Drosophila embryo .
22940129	0	osmotic_stress_transcription_factor_1	22,59	OSTF1	61,66	osmotic stress transcription factor 1	OSTF1	100707559	100707559	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	miR-429 regulation of osmotic_stress_transcription_factor_1 -LRB- OSTF1 -RRB- in tilapia during osmotic stress .
16970923	0	osteoadherin	27,39	OSAD	41,45	osteoadherin	OSAD	4958	4958	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Differential regulation of osteoadherin -LRB- OSAD -RRB- by TGF-beta1 and BMP-2 .
16970923	0	osteoadherin	27,39	TGF-beta1	50,59	osteoadherin	TGF-beta1	4958	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of osteoadherin -LRB- OSAD -RRB- by TGF-beta1 and BMP-2 .
12489179	0	osteoadherin	40,52	TGF_beta_1	0,10	osteoadherin	TGF beta 1	4958	7040	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	TGF_beta_1 signaling and stimulation of osteoadherin in human odontoblasts in vitro .
9325176	0	osteoblast-specific_factor-1	14,42	OSF-1	44,49	osteoblast-specific factor-1	OSF-1	19242(Tax:10090)	19242(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Regulation of osteoblast-specific_factor-1 -LRB- OSF-1 -RRB- mRNA expression by dual promoters as revealed by RT-PCR .
7663166	0	osteoblast-specific_factor_2	42,70	OSF-2	72,77	osteoblast-specific factor 2	OSF-2	50706(Tax:10090)	50706(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and characterization of murine osteoblast-specific_factor_2 -LRB- OSF-2 -RRB- in a baculovirus expression system .
8119149	0	osteocalcin	121,132	D3_and_tumor_necrosis_factor-alpha	75,109	osteocalcin	D3 and tumor necrosis factor-alpha	81613(Tax:10116)	24835(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	A single up-stream element confers responsiveness to 1,25-dihydroxyvitamin _ D3_and_tumor_necrosis_factor-alpha in the rat osteocalcin gene .
9819228	0	osteocalcin	25,36	Msx2	79,83	osteocalcin	Msx2	81613(Tax:10116)	25483(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY transcription|nsubj|regulation transcription|nmod|END_ENTITY	Reciprocal regulation of osteocalcin transcription by the homeodomain proteins Msx2 and Dlx5 .
25955226	0	osteocalcin	54,65	PTH	29,32	osteocalcin	PTH	12097(Tax:10090)	5741	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of treatment with PTH on undercarboxylated osteocalcin and energy metabolism in hypoparathyroidism .
9231754	0	osteocalcin	49,60	PTH	21,24	osteocalcin	PTH	81613(Tax:10116)	5741	Gene	Gene	START_ENTITY|nsubj|regulation regulation|appos|END_ENTITY	Parathyroid_hormone -LRB- PTH 1-34 -RRB- regulation of rat osteocalcin gene transcription .
11668178	0	osteocalcin	64,75	Runx2	114,119	osteocalcin	Runx2	81613(Tax:10116)	367218(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	CCAAT/enhancer-binding _ proteins -LRB- C/EBP -RRB- _ beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression .
24389415	0	osteocalcin	43,54	SMILE	0,5	osteocalcin	SMILE	12097(Tax:10090)	233490(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	SMILE inhibits BMP-2-induced expression of osteocalcin by suppressing the activity of the RUNX2 transcription factor in MC3T3E1 cells .
26259649	0	osteocalcin	50,61	insulin	65,72	osteocalcin	insulin	12097(Tax:10090)	3630	Gene	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo .
22405968	0	osteocalcin	47,58	p53	0,3	osteocalcin	p53	81613(Tax:10116)	301300(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression involved|nmod|regulation involved|nsubjpass|END_ENTITY	p53 and MDM2 are involved in the regulation of osteocalcin gene expression .
10693864	0	osteoclast_differentiation_factor	66,99	receptor_activator_of_nuclear_factor_kappaB_ligand	15,65	osteoclast differentiation factor	receptor activator of nuclear factor kappaB ligand	8600	8600	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of receptor_activator_of_nuclear_factor_kappaB_ligand / osteoclast_differentiation_factor in osteoclastogenesis from synoviocytes in rheumatoid_arthritis .
18465072	0	osteoclast_inhibitory_lectin	33,61	OCIL	63,67	osteoclast inhibitory lectin	OCIL	29121	29121	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Asn19Lys substitution in the osteoclast_inhibitory_lectin -LRB- OCIL -RRB- gene is associated with a reduction of bone_mineral_density in postmenopausal women .
9714833	0	osteoclastogenesis_inhibitory_factor	23,59	OCIF	61,65	osteoclastogenesis inhibitory factor	OCIF	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the mouse osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- gene and its expression in embryogenesis .
10469276	0	osteoclastogenesis_inhibitory_factor	31,67	osteoprotegerin	14,29	osteoclastogenesis inhibitory factor	osteoprotegerin	4982	4982	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of osteoprotegerin -LRB- osteoclastogenesis_inhibitory_factor -RRB- in cultures of human dental mesenchymal cells and epithelial cells .
10418861	0	osteogenic_protein-1	39,59	BMP-7	61,66	osteogenic protein-1	BMP-7	655	655	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Preclinical and clinical evaluation of osteogenic_protein-1 -LRB- BMP-7 -RRB- in bony sites .
11769973	0	osteogenic_protein-1	118,138	Transforming_growth_factor-beta1	0,32	osteogenic protein-1	Transforming growth factor-beta1	655	7040	Gene	Gene	initiated|nmod|START_ENTITY bone|acl|initiated morphogenesis|nmod|bone supports|dobj|morphogenesis supports|nsubj|END_ENTITY	Transforming_growth_factor-beta1 supports the rapid morphogenesis of heterotopic endochondral bone initiated by human osteogenic_protein-1 via the synergistic upregulation of molecular markers .
12472235	0	osteogenic_protein-1	32,52	bone_morphogenetic_protein-7	54,82	osteogenic protein-1	bone morphogenetic protein-7	655	655	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of recombinant human osteogenic_protein-1 -LRB- bone_morphogenetic_protein-7 -RRB- impregnation on allografts in a canine intercalary bone defect .
7560881	0	osteogenic_protein-1	22,42	bone_morphogenetic_protein-7	44,72	osteogenic protein-1	bone morphogenetic protein-7	655	655	Gene	Gene	pattern|nmod|START_ENTITY pattern|dep|END_ENTITY	Expression pattern of osteogenic_protein-1 -LRB- bone_morphogenetic_protein-7 -RRB- in human and mouse development .
9333119	0	osteogenic_protein-1	117,137	transforming_growth_factor-beta1	12,44	osteogenic protein-1	transforming growth factor-beta1	655	101006627	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Recombinant transforming_growth_factor-beta1 induces endochondral bone_in_the_baboon_and_synergizes with recombinant osteogenic_protein-1 -LRB- bone_morphogenetic_protein-7 -RRB- to initiate rapid bone formation .
1438217	0	osteogenic_protein_1	75,95	neural_cell_adhesion_molecule	17,46	osteogenic protein 1	neural cell adhesion molecule	12162(Tax:10090)	17967(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of the neural_cell_adhesion_molecule and neuronal_aggregation by osteogenic_protein_1 .
1730648	0	osteoinductive_factor	133,154	Proteoglycan-Lb	0,15	osteoinductive factor	Proteoglycan-Lb	4969	417890(Tax:9031)	Gene	Gene	related|xcomp|START_ENTITY related|nsubjpass|END_ENTITY	Proteoglycan-Lb , a small dermatan sulfate proteoglycan expressed in embryonic chick_epiphyseal_cartilage , is structurally related to osteoinductive_factor .
26136925	0	osteopontin	10,21	ADAMTS4	48,55	osteopontin	ADAMTS4	6696	9507	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|nmod|END_ENTITY	Effect of osteopontin on the mRNA expression of ADAMTS4 and ADAMTS5 in chondrocytes from patients with knee_osteoarthritis .
15857938	0	osteopontin	18,29	Bcr-Abl	0,7	osteopontin	Bcr-Abl	6696	25	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Bcr-Abl regulates osteopontin transcription via Ras , PI-3K , aPKC , Raf-1 , and MEK .
17227585	0	osteopontin	55,66	Breast_cancer_metastasis_suppressor_1	0,37	osteopontin	Breast cancer metastasis suppressor 1	6696	25855	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Breast_cancer_metastasis_suppressor_1 -LRB- BRMS1 -RRB- inhibits osteopontin transcription by abrogating NF-kappaB activation .
14712233	0	osteopontin	36,47	C/EBPalpha	60,70	osteopontin	C/EBPalpha	6696	1050	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Transcriptional regulation of human osteopontin promoter by C/EBPalpha and AML-1 in metastatic_cancer cells .
23545719	0	osteopontin	31,42	CD133	59,64	osteopontin	CD133	6696	8842	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localisation of osteopontin and prominin-1 -LRB- CD133 -RRB- in patients with endometriosis .
14555839	0	osteopontin	21,32	CD4	93,96	osteopontin	CD4	20750(Tax:10090)	12504(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|proliferation proliferation|nmod|lymphocytes lymphocytes|compound|END_ENTITY	The roles of soluble osteopontin using osteopontin-transgenic_mice in vivo : proliferation of CD4 + T lymphocytes and the enhancement of cell-mediated immune responses .
19017937	0	osteopontin	10,21	CD4	82,85	osteopontin	CD4	6696	920	Gene	Gene	expression|compound|START_ENTITY amplifies|nsubj|expression amplifies|nmod|cells cells|nummod|END_ENTITY	Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4 + T cells in experimental_autoimmune_encephalomyelitis and in multiple_sclerosis .
19670379	0	osteopontin	48,59	CD4	73,76	osteopontin	CD4	20750(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4 + T Cells in MS. IFN-beta currently serves as one of the major treatments for MS. Its anti-inflammatory mechanism has been reported as involving a shift in cytokine balance from Th1 to Th2 in the T-cell response against elements of the myelin sheath .
23617736	0	osteopontin	12,23	CD40	48,52	osteopontin	CD40	6696	958	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	The role of osteopontin in the induction of the CD40 ligand in Graves ' _ disease .
10088720	0	osteopontin	37,48	CD44	0,4	osteopontin	CD44	6696	960	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	CD44 is not an adhesive receptor for osteopontin .
10733576	0	osteopontin	12,23	CD44	54,58	osteopontin	CD44	20750(Tax:10090)	12505(Tax:10090)	Gene	Gene	Coupling|nmod|START_ENTITY surface|nsubj|Coupling surface|dobj|END_ENTITY	Coupling of osteopontin and its cell surface receptor CD44 to the cell survival response elicited by interleukin-3 or granulocyte-macrophage_colony-stimulating_factor .
16402410	0	osteopontin	4,15	CD44	18,22	osteopontin	CD44	20750(Tax:10090)	12505(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|superfluous superfluous|nsubj|END_ENTITY	The osteopontin - CD44 pathway is superfluous for the development of autoimmune_myocarditis .
16631740	0	osteopontin	137,148	CD44	73,77	osteopontin	CD44	6696	960	Gene	Gene	required|nmod|START_ENTITY required|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression , MMP-2 secretion , and cell migration by osteopontin in human melanoma cells .
16691370	0	osteopontin	58,69	CD44	22,26	osteopontin	CD44	6696	960	Gene	Gene	expression|nmod|START_ENTITY facilitates|nsubj|expression variant|acl:relcl|facilitates variant|compound|END_ENTITY	Enhanced cell surface CD44 variant -LRB- v6 , v9 -RRB- expression by osteopontin in breast_cancer epithelial cells facilitates tumor cell migration : novel post-transcriptional , post-translational regulation .
25009318	0	osteopontin	23,34	CD44	58,62	osteopontin	CD44	6696	960	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nsubj|association	Genetic association of osteopontin -LRB- OPN -RRB- and its receptor CD44 genes with susceptibility to Chinese gastric_cancer patients .
9892210	0	osteopontin	97,108	CD44	0,4	osteopontin	CD44	6696	960	Gene	Gene	permit|advcl|START_ENTITY cooperate|xcomp|permit cooperate|nsubj|variants variants|compound|END_ENTITY	CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic_acid , thereby stimulating cell motility and chemotaxis .
20553297	0	osteopontin	18,29	Clara_cell_10_kDa_protein	55,80	osteopontin	Clara cell 10 kDa protein	6696	7356	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of osteopontin and its association with Clara_cell_10_kDa_protein in allergic_rhinitis .
24963635	0	osteopontin	36,47	ERK	56,59	osteopontin	ERK	6696	5594	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Cell stress induces upregulation of osteopontin via the ERK pathway in type II alveolar epithelial cells .
23680656	0	osteopontin	21,32	ERRa	45,49	osteopontin	ERRa	6696	2101	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Control of the human osteopontin promoter by ERRa in colorectal_cancer .
12465727	0	osteopontin	14,25	Eta-1	27,32	osteopontin	Eta-1	6696	6696	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of osteopontin -LRB- Eta-1 -RRB- in Crohn_disease of the terminal ileum .
19556240	0	osteopontin	108,119	GLI1	42,46	osteopontin	GLI1	20750(Tax:10090)	14632(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin .
22266849	0	osteopontin	107,118	GSK3b	53,58	osteopontin	GSK3b	6696	2932	Gene	Gene	target|appos|START_ENTITY mediated|nmod|target mediated|dobj|dephosphorylation dephosphorylation|nmod|END_ENTITY	DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3b to downregulate b-catenin transcription target , osteopontin .
25565601	0	osteopontin	39,50	GSK3b	0,5	osteopontin	GSK3b	20750(Tax:10090)	56637(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GSK3b negatively regulates LPS-induced osteopontin expression via inhibiting its transcription .
22675553	0	osteopontin	35,46	Hepatocyte_growth_factor	0,24	osteopontin	Hepatocyte growth factor	6696	3082	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Hepatocyte_growth_factor increases osteopontin expression in human osteoblasts through PI3K , Akt , c-Src , and AP-1 signaling pathway .
19670379	0	osteopontin	48,59	IFN-beta	22,30	osteopontin	IFN-beta	20750(Tax:10090)	15977(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4 + T Cells in MS. IFN-beta currently serves as one of the major treatments for MS. Its anti-inflammatory mechanism has been reported as involving a shift in cytokine balance from Th1 to Th2 in the T-cell response against elements of the myelin sheath .
12804068	0	osteopontin	23,34	IFN-gamma	0,9	osteopontin	IFN-gamma	6696	3458	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	IFN-gamma induction of osteopontin expression in human monocytoid cells .
22784028	0	osteopontin	15,26	IFN-y	0,5	osteopontin	IFN-y	6696	3458	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	IFN-y inhibits osteopontin expression in human decidual stromal cells and can be attenuated by 1a,25-dihydroxyvitamin _ D3 .
19429811	0	osteopontin	19,30	IL-18	0,5	osteopontin	IL-18	20750(Tax:10090)	16173(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IL-18 induction of osteopontin mediates cardiac_fibrosis and diastolic_dysfunction in mice .
22779921	0	osteopontin	39,50	MAP1A	67,72	osteopontin	MAP1A	6696	4130	Gene	Gene	associates|compound|START_ENTITY associates|nmod|END_ENTITY	A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability , apoptosis and protein degradation in the human brain .
14975209	0	osteopontin	16,27	MMP-2	79,84	osteopontin	MMP-2	6696	4313	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of human osteopontin on proliferation , transmigration and expression of MMP-2 and MMP-9 in osteosarcoma cells .
20207476	0	osteopontin	30,41	MMP-2	56,61	osteopontin	MMP-2	6696	4313	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|expressions expressions|amod|END_ENTITY	A short-hairpin RNA targeting osteopontin downregulates MMP-2 and MMP-9 expressions in prostate_cancer PC-3 cells .
21174062	0	osteopontin	19,30	MMP-2	111,116	osteopontin	MMP-2	20750(Tax:10090)	17390(Tax:10090)	Gene	Gene	Down-regulation|nmod|START_ENTITY inhibits|nsubj|Down-regulation inhibits|dobj|metastasis metastasis|nmod|cells cells|nmod|mechanism mechanism|nmod|END_ENTITY	Down-regulation of osteopontin inhibits metastasis of hepatocellular_carcinoma cells via a mechanism involving MMP-2 and uPA .
22917927	0	osteopontin	48,59	MMP-2	8,13	osteopontin	MMP-2	20750(Tax:10090)	17390(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|Loss Loss|nmod|END_ENTITY	Loss of MMP-2 in murine osteoblasts upregulates osteopontin and bone sialoprotein expression in a circuit regulating bone homeostasis .
9639398	0	osteopontin	70,81	MMP-2	14,19	osteopontin	MMP-2	6696	4313	Gene	Gene	induced|nmod|START_ENTITY cells|acl|induced END_ENTITY|nmod|cells	Activation of MMP-2 by human GCT23 giant_cell_tumour cells induced by osteopontin , bone sialoprotein and GRGDSP peptides is RGD and cell shape change dependent .
14988426	0	osteopontin	18,29	NURR1	66,71	osteopontin	NURR1	20750(Tax:10090)	18227(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts .
12753549	0	osteopontin	14,25	OPN	27,30	osteopontin	OPN	281499(Tax:9913)	281499(Tax:9913)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of osteopontin -LRB- OPN -RRB- mRNA in bovine ovarian follicles and corpora lutea .
18835636	0	osteopontin	10,21	OPN	23,26	osteopontin	OPN	281499(Tax:9913)	281499(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of osteopontin -LRB- OPN -RRB- on in vitro embryo development in cattle .
20010486	0	osteopontin	60,71	OPN	73,76	osteopontin	OPN	397087(Tax:9823)	397087(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The study of polymorphism within the promoter region of the osteopontin -LRB- OPN -RRB- gene in sows .
20219412	0	osteopontin	19,30	OPN	32,35	osteopontin	OPN	6696	6696	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The implication of osteopontin -LRB- OPN -RRB- expression and genetic polymorphisms of OPN promoter in oral carcinogenesis .
23352191	0	osteopontin	24,35	OPN	36,39	osteopontin	OPN	6696	6696	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Placental expression of osteopontin -LRB- OPN -RRB- in monochorionic twins with discordant growth .
26592666	0	osteopontin	44,55	OPN	57,60	osteopontin	OPN	6696	6696	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Epigenetic regulation of glucose-stimulated osteopontin -LRB- OPN -RRB- expression in diabetic kidney .
19602124	0	osteopontin	24,35	Osteoprotegerin	0,15	osteopontin	Osteoprotegerin	6696	4982	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Osteoprotegerin induces osteopontin via syndecan-1_and_phosphoinositol_3-kinase / Akt in human periodontal ligament cells .
20868520	0	osteopontin	35,46	PC3	50,53	osteopontin	PC3	6696	5122	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Regulation of Erk1/2 activation by osteopontin in PC3 human prostate_cancer cells .
19798549	0	osteopontin	48,59	RhoA	14,18	osteopontin	RhoA	6696	387	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|Activation Activation|nmod|END_ENTITY	Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts .
22261033	0	osteopontin	29,40	SPP1	42,46	osteopontin	SPP1	6696	6696	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Cigarette smoke induction of osteopontin -LRB- SPP1 -RRB- mediates T -LRB- H -RRB- 17 inflammation in human and experimental emphysema .
23784265	0	osteopontin	37,48	SPP1	55,59	osteopontin	SPP1	6696	6696	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between polymorphisms in osteopontin gene -LRB- SPP1 -RRB- and first episode calcium_oxalate urolithiasis .
17689681	0	osteopontin	14,25	Sp1	0,3	osteopontin	Sp1	6696	6667	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sp1 regulates osteopontin expression in SW480 human colon_adenocarcinoma cells .
16204248	0	osteopontin	54,65	TIS7	0,4	osteopontin	TIS7	20750(Tax:10090)	15982(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	TIS7 regulation of the beta-catenin/Tcf -4 target gene osteopontin -LRB- OPN -RRB- is histone deacetylase-dependent .
27026194	0	osteopontin	14,25	TRAF3	37,42	osteopontin	TRAF3	20750(Tax:10090)	22031(Tax:10090)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|END_ENTITY	Intracellular osteopontin stabilizes TRAF3 to positively regulate innate antiviral response .
22037483	0	osteopontin	17,28	aryl_hydrocarbon_receptor	43,68	osteopontin	aryl hydrocarbon receptor	6696	196	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of osteopontin expression by aryl_hydrocarbon_receptor via both ligand-dependent and ligand-independent pathways in lung_cancer .
11780235	0	osteopontin	79,90	bone_morphogenetic_protein-2	29,57	osteopontin	bone morphogenetic protein-2	6696	650	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of recombinant human bone_morphogenetic_protein-2 on the expression of osteopontin in human periodontal ligament cells -RSB- .
19790060	0	osteopontin	52,63	carboxypeptidase_B	21,39	osteopontin	carboxypeptidase B	6696	57094	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Thrombin-activatable carboxypeptidase_B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid_arthritis .
17160024	0	osteopontin	78,89	caspase-3	126,135	osteopontin	caspase-3	20750(Tax:10090)	12367(Tax:10090)	Gene	Gene	downstream|compound|START_ENTITY downstream|nmod|END_ENTITY	Chemotherapy resistance of mouse WAP-SVT/t breast_cancer cells is mediated by osteopontin , inhibiting apoptosis downstream of caspase-3 .
18353062	0	osteopontin	59,70	interleukin-2	10,23	osteopontin	interleukin-2	6696	3558	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of interleukin-2 and tumor_necrosis_factor-alpha on osteopontin : molecular function and biological process .
25639047	0	osteopontin	11,22	matrix_metalloproteinase_13	40,67	osteopontin	matrix metalloproteinase 13	6696	4322	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effect of osteopontin on expression of matrix_metalloproteinase_13 in human knee osteoarthritic chondrocytes -RSB- .
19565503	0	osteopontin	8,19	monocyte_chemoattractant_protein_1	36,70	osteopontin	monocyte chemoattractant protein 1	6696	6347	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Role of osteopontin in induction of monocyte_chemoattractant_protein_1 and macrophage_inflammatory_protein_1beta through the NF-kappaB and MAPK pathways in rheumatoid_arthritis .
1633816	0	osteopontin	60,71	opn	55,58	osteopontin	opn	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Characterization of the promoter region of the porcine opn -LRB- osteopontin , secreted_phosphoprotein_1 -RRB- gene .
19339987	0	osteopontin	45,56	osteopontin	81,92	osteopontin	osteopontin	6696	6696	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Age - and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic_lupus_erythematosus .
19339987	0	osteopontin	81,92	osteopontin	45,56	osteopontin	osteopontin	6696	6696	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Age - and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic_lupus_erythematosus .
17852826	0	osteopontin	61,72	osteoprotegerin	74,89	osteopontin	osteoprotegerin	6696	4982	Gene	Gene	activator|compound|START_ENTITY activator|dep|END_ENTITY	Biological variation and reference intervals for circulating osteopontin , osteoprotegerin , total soluble receptor activator of nuclear factor kappa B ligand and high-sensitivity C-reactive protein .
18612923	0	osteopontin	22,33	osteoprotegerin	35,50	osteopontin	osteoprotegerin	6696	4982	Gene	Gene	activator|compound|START_ENTITY activator|dep|END_ENTITY	Circulating levels of osteopontin , osteoprotegerin , total soluble receptor activator of nuclear factor-kappa B ligand , and high-sensitivity C-reactive protein in patients with active rheumatoid_arthritis randomized to etanercept alone or in combination with methotrexate .
27048108	0	osteopontin	18,29	p21ras	80,86	osteopontin	p21ras	6696	3265	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of osteopontin in breast_cancer tissue and its relationship with p21ras and CD44V6 expression .
24069507	0	osteopontin	30,41	spp1	43,47	osteopontin	spp1	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Transgenic mammary epithelial osteopontin -LRB- spp1 -RRB- expression induces proliferation and alveologenesis .
9525990	0	osteopontin	51,62	spp1	69,73	osteopontin	spp1	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Altered wound healing in mice lacking a functional osteopontin gene -LRB- spp1 -RRB- .
18956641	0	osteoprotegerin	41,56	Adiponectin	1,12	osteoprotegerin	Adiponectin	4982	9370	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- Adiponectin regulates the expression of osteoprotegerin and receptor_activator_of_nuclear_factor-kappaB_ligand in human osteoblast -RSB- .
19170762	0	osteoprotegerin	73,88	Bone_morphogenetic_protein-2	0,28	osteoprotegerin	Bone morphogenetic protein-2	18383(Tax:10090)	12156(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 enhances Wnt/beta-catenin signaling-induced osteoprotegerin expression .
16611736	0	osteoprotegerin	14,29	CGRP	0,4	osteoprotegerin	CGRP	4982	796	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP/PKA-dependent pathway .
17332531	0	osteoprotegerin	26,41	Growth_hormone	0,14	osteoprotegerin	Growth hormone	4982	2688	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Growth_hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells .
12213884	0	osteoprotegerin	16,31	IGF-I	0,5	osteoprotegerin	IGF-I	4982	3479	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IGF-I regulates osteoprotegerin -LRB- OPG -RRB- and receptor_activator_of_nuclear_factor-kappaB ligand in vitro and OPG in vivo .
16601843	0	osteoprotegerin	39,54	Interleukin-4	0,13	osteoprotegerin	Interleukin-4	4982	3565	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-4 differentially regulates osteoprotegerin expression and induces calcification in vascular smooth muscle cells .
18251702	0	osteoprotegerin	68,83	Interleukin-4	0,13	osteoprotegerin	Interleukin-4	4982	3565	Gene	Gene	stimulate|dobj|START_ENTITY END_ENTITY|dep|stimulate	Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway .
26751719	0	osteoprotegerin	17,32	Jagged1	0,7	osteoprotegerin	Jagged1	4982	182	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Jagged1 inhibits osteoprotegerin expression by human periodontal ligament cells .
18846253	0	osteoprotegerin	25,40	NFATc1	0,6	osteoprotegerin	NFATc1	18383(Tax:10090)	18018(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism .
12070273	0	osteoprotegerin	16,31	OPG	33,36	osteoprotegerin	OPG	25341(Tax:10116)	25341(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of osteoprotegerin -LRB- OPG -RRB- on bone surfaces and cement lines in rat tibia .
15042606	0	osteoprotegerin	6,21	OPG	23,26	osteoprotegerin	OPG	4982	4982	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum osteoprotegerin -LRB- OPG -RRB- levels are associated with disease progression and response to androgen ablation in patients with prostate_cancer .
15241009	0	osteoprotegerin	13,28	OPG	30,33	osteoprotegerin	OPG	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of osteoprotegerin -LRB- OPG -RRB- on resorption of heterotopically induced ossicle .
15775414	0	osteoprotegerin	45,60	OPG	62,65	osteoprotegerin	OPG	4982	4982	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- -RSB- .
16464170	0	osteoprotegerin	8,23	OPG	25,28	osteoprotegerin	OPG	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of osteoprotegerin -LRB- OPG -RRB- in cancer .
17453373	0	osteoprotegerin	122,137	OPG	139,142	osteoprotegerin	OPG	4982	4982	Gene	Gene	axis|compound|START_ENTITY axis|appos|END_ENTITY	Abnormal bone remodeling process is due to an imbalance in the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- axis in patients with solid tumors metastatic to the skeleton .
19058561	0	osteoprotegerin	13,28	OPG	30,33	osteoprotegerin	OPG	18383(Tax:10090)	18383(Tax:10090)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of osteoprotegerin -LRB- OPG -RRB- on experimentally induced ectopic bone .
21678294	0	osteoprotegerin	15,30	OPG	32,35	osteoprotegerin	OPG	4982	4982	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The effects of osteoprotegerin -LRB- OPG -RRB- gene polymorphism in patients with ischaemic_heart_disease on the morphology of coronary arteries and bone_mineral_density .
23277172	0	osteoprotegerin	10,25	OPG	27,30	osteoprotegerin	OPG	4982	4982	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TRAIL and osteoprotegerin -LRB- OPG -RRB- expression in bladder urothelial_carcinoma : correlation with clinicopathological parameters and prognosis .
23304691	0	osteoprotegerin	12,27	OPG	29,32	osteoprotegerin	OPG	4982	4982	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of osteoprotegerin -LRB- OPG -RRB- gene polymorphism in Iranian patients with chronic_periodontitis and peri-implantitis .
10225954	0	osteoprotegerin	15,30	OPGL	32,36	osteoprotegerin	OPGL	25341(Tax:10116)	117516(Tax:10116)	Gene	Gene	ligand|nmod|START_ENTITY ligand|appos|END_ENTITY	The ligand for osteoprotegerin -LRB- OPGL -RRB- directly activates mature osteoclasts .
10433211	0	osteoprotegerin	51,66	Parathyroid_hormone	0,19	osteoprotegerin	Parathyroid hormone	18383(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Parathyroid_hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures : correlation with osteoclast-like cell formation .
18945829	0	osteoprotegerin	42,57	Parathyroid_hormone	0,19	osteoprotegerin	Parathyroid hormone	4982	5741	Gene	Gene	secretion|compound|START_ENTITY decreases|dobj|secretion decreases|nsubj|END_ENTITY	Parathyroid_hormone decreases endothelial osteoprotegerin secretion : role of protein kinase A and C. Parathyroid_hormone -LRB- PTH -RRB- , which is elevated in patients with chronic_renal_failure , has been shown to participate in the development of vascular_calcification .
14578201	0	osteoprotegerin	59,74	RANKL	52,57	osteoprotegerin	RANKL	4982	8600	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|Receptor_activator_of_nuclear_factor_kappaB_ligand Receptor_activator_of_nuclear_factor_kappaB_ligand|dep|END_ENTITY	Receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- ratio is increased in severe osteolysis .
14675140	0	osteoprotegerin	206,221	RANKL	151,156	osteoprotegerin	RANKL	4982	8600	Gene	Gene	START_ENTITY|nsubj|osteoclast_differentiation_factor osteoclast_differentiation_factor|dep|receptor_activator_of_nuclear_factor-kappaB_ligand receptor_activator_of_nuclear_factor-kappaB_ligand|dep|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- , osteoclast_differentiation_factor -LRB- ODF -RRB- / receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- and osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- in ameloblastomas .
14678293	0	osteoprotegerin	6,21	RANKL	68,73	osteoprotegerin	RANKL	4982	8600	Gene	Gene	kB|nsubj|START_ENTITY kB|dobj|concentrations concentrations|appos|END_ENTITY	Serum osteoprotegerin and receptor activator of nuclear factors kB -LRB- RANKL -RRB- concentrations in normal children and in children with pubertal precocity , Turner 's _ syndrome and rheumatoid_arthritis .
15327520	0	osteoprotegerin	69,84	RANKL	61,66	osteoprotegerin	RANKL	4982	8600	Gene	Gene	1-alpha|amod|START_ENTITY 1-alpha|amod|receptor_activator_of_nuclear_factor-kappa_B_ligand receptor_activator_of_nuclear_factor-kappa_B_ligand|dep|END_ENTITY	Role of receptor_activator_of_nuclear_factor-kappa_B_ligand -LRB- RANKL -RRB- , osteoprotegerin and macrophage protein 1-alpha -LRB- MIP-1a -RRB- in monoclonal_gammopathy_of_undetermined_significance -LRB- MGUS -RRB- .
15544627	0	osteoprotegerin	113,128	RANKL	64,69	osteoprotegerin	RANKL	4982	8600	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|receptor_activator_of_NF-kappaB_ligand receptor_activator_of_NF-kappaB_ligand|appos|END_ENTITY	Increased expression of receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- , its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn 's _ disease patients .
16736519	0	osteoprotegerin	25,40	RANKL	44,49	osteoprotegerin	RANKL	4982	8600	Gene	Gene	circulating|dobj|START_ENTITY circulating|advcl|END_ENTITY	The ratio of circulating osteoprotegerin to RANKL in early rheumatoid_arthritis predicts later_joint_destruction .
16828054	0	osteoprotegerin	20,35	RANKL	178,183	osteoprotegerin	RANKL	4982	8600	Gene	Gene	Characterization|nmod|START_ENTITY binding|nsubj|Characterization binding|nmod|resonance resonance|dep|role role|nmod|interactions interactions|nmod|receptor_activator_of_nuclear_factor_kappaB_ligand receptor_activator_of_nuclear_factor_kappaB_ligand|appos|END_ENTITY	Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance : role in the interactions with receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- and RANK .
16912914	0	osteoprotegerin	32,47	RANKL	15,20	osteoprotegerin	RANKL	25341(Tax:10116)	117516(Tax:10116)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Effects of the RANKL inhibitor , osteoprotegerin , on the pain and histopathology of bone_cancer in rats .
17328075	0	osteoprotegerin	6,21	RANKL	0,5	osteoprotegerin	RANKL	4982	8600	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	RANKL : osteoprotegerin ratio and bone_mineral_density in children with untreated juvenile_dermatomyositis .
17453373	0	osteoprotegerin	122,137	RANKL	115,120	osteoprotegerin	RANKL	4982	8600	Gene	Gene	axis|compound|START_ENTITY axis|appos|END_ENTITY	Abnormal bone remodeling process is due to an imbalance in the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- axis in patients with solid tumors metastatic to the skeleton .
17530461	0	osteoprotegerin	13,28	RANKL	0,5	osteoprotegerin	RANKL	18383(Tax:10090)	21943(Tax:10090)	Gene	Gene	RANK|appos|START_ENTITY RANK|compound|END_ENTITY	RANKL , RANK , osteoprotegerin : key partners of osteoimmunology and vascular_diseases .
17608585	0	osteoprotegerin	25,40	RANKL	0,5	osteoprotegerin	RANKL	4982	8600	Gene	Gene	blocks|compound|START_ENTITY inhibition|nmod|blocks inhibition|amod|END_ENTITY	RANKL inhibition through osteoprotegerin blocks bone_loss in experimental periodontitis .
18025194	0	osteoprotegerin	31,46	RANKL	11,16	osteoprotegerin	RANKL	18383(Tax:10090)	21943(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY inhibition|nmod|transgenic_mice inhibition|compound|END_ENTITY	Continuous RANKL inhibition in osteoprotegerin transgenic_mice and rats suppresses bone resorption without impairing lymphorganogenesis or functional immune responses .
18355453	0	osteoprotegerin	30,45	RANKL	134,139	osteoprotegerin	RANKL	4982	8600	Gene	Gene	levels|nmod|START_ENTITY ligand|nsubj|levels ligand|dobj|END_ENTITY	High levels of synovial fluid osteoprotegerin -LRB- OPG -RRB- and increased serum ratio of receptor activator of nuclear factor-kappa B ligand -LRB- RANKL -RRB- to OPG correlate with disease severity in patients with primary knee_osteoarthritis .
18433301	0	osteoprotegerin	22,37	RANKL	0,5	osteoprotegerin	RANKL	25341(Tax:10116)	117516(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	RANKL inhibition with osteoprotegerin increases bone strength by improving cortical and trabecular bone architecture in ovariectomized rats .
18584413	0	osteoprotegerin	14,29	RANKL	186,191	osteoprotegerin	RANKL	4982	8600	Gene	Gene	activator|compound|START_ENTITY Expression|nmod|activator ligand|nsubj|Expression ligand|nmod|expression expression|amod|END_ENTITY	Expression of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand -LRB- RANKL -RRB- in HCC70 breast_cancer cells and effects of treatment with gonadotropin-releasing_hormone on RANKL expression .
18584413	0	osteoprotegerin	14,29	RANKL	86,91	osteoprotegerin	RANKL	4982	8600	Gene	Gene	activator|compound|START_ENTITY Expression|nmod|activator ligand|nsubj|Expression ligand|dobj|END_ENTITY	Expression of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand -LRB- RANKL -RRB- in HCC70 breast_cancer cells and effects of treatment with gonadotropin-releasing_hormone on RANKL expression .
19040304	0	osteoprotegerin	116,131	RANKL	107,112	osteoprotegerin	RANKL	25341(Tax:10116)	117516(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY increased|nmod|ratio increased|dobj|END_ENTITY	The HLA-B27 transgenic rat , a model of spondyloarthritis , has decreased bone mineral density and increased RANKL to osteoprotegerin mRNA ratio .
20003323	0	osteoprotegerin	20,35	RANKL	0,5	osteoprotegerin	RANKL	25341(Tax:10116)	117516(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	RANKL inhibition by osteoprotegerin prevents bone_loss without affecting local or systemic inflammation parameters in two rat arthritis models : comparison with anti-TNFalpha or anti-IL-1 therapies .
21870142	0	osteoprotegerin	12,27	RANKL	87,92	osteoprotegerin	RANKL	4982	8600	Gene	Gene	role|nmod|START_ENTITY activator|dep|role activator|nmod|ligand ligand|appos|END_ENTITY	The role of osteoprotegerin -LRB- OPG -RRB- receptor activator for nuclear factor kappaB ligand -LRB- RANKL -RRB- in cardiovascular pathology - a review .
22664871	0	osteoprotegerin	67,82	RANKL	27,32	osteoprotegerin	RANKL	4982	8600	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin .
23018352	0	osteoprotegerin	22,37	RANKL	100,105	osteoprotegerin	RANKL	4982	8600	Gene	Gene	Correlation|nmod|START_ENTITY ligand|nsubj|Correlation ligand|dobj|levels levels|appos|END_ENTITY	Correlation of plasma osteoprotegerin -LRB- OPG -RRB- and receptor activator of the nuclear factor kB ligand -LRB- RANKL -RRB- levels with clinical risk factors in patients with advanced carotid_atherosclerosis .
25138051	0	osteoprotegerin	44,59	RANKL	106,111	osteoprotegerin	RANKL	4982	8600	Gene	Gene	mimics|dobj|START_ENTITY mimics|advcl|interacting interacting|nmod|site site|nmod|END_ENTITY	Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL .
20476881	0	osteoprotegerin	52,67	Receptor_activator_of_nuclear_factor-kappa_B_ligand	0,51	osteoprotegerin	Receptor activator of nuclear factor-kappa B ligand	4982	8600	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|dep|ratio	Receptor_activator_of_nuclear_factor-kappa_B_ligand / osteoprotegerin ratio in sites of chronic_periodontitis of subjects with poorly and well-controlled type 2 diabetes .
14578201	0	osteoprotegerin	59,74	Receptor_activator_of_nuclear_factor_kappaB_ligand	0,50	osteoprotegerin	Receptor activator of nuclear factor kappaB ligand	4982	8600	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- ratio is increased in severe osteolysis .
21903966	0	osteoprotegerin	58,73	TNFRSF11B	80,89	osteoprotegerin	TNFRSF11B	4982	4982	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assessment of the genetic effects of polymorphisms in the osteoprotegerin gene , TNFRSF11B , on serum osteoprotegerin levels and carotid plaque vulnerability .
21994215	0	osteoprotegerin	47,62	TNFRSF11B	36,45	osteoprotegerin	TNFRSF11B	4982	4982	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Functional polymorphisms within the TNFRSF11B -LRB- osteoprotegerin -RRB- gene increase the risk for low bone mineral density .
16394281	0	osteoprotegerin	14,29	TRAIL	76,81	osteoprotegerin	TRAIL	4982	8743	Gene	Gene	Expression|nmod|START_ENTITY apoptosis|nsubj|Expression apoptosis|xcomp|inducing inducing|dobj|ligand ligand|appos|END_ENTITY	Expression of osteoprotegerin -LRB- OPG -RRB- , TNF related apoptosis inducing ligand -LRB- TRAIL -RRB- , and receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- in human breast_tumours .
18266968	0	osteoprotegerin	64,79	TRAIL	8,13	osteoprotegerin	TRAIL	4982	8743	Gene	Gene	activity|nmod|START_ENTITY impair|dobj|activity impair|nsubj|END_ENTITY	Soluble TRAIL does not impair the anti-osteoclastic activity of osteoprotegerin .
21251686	0	osteoprotegerin	158,173	TRAIL	83,88	osteoprotegerin	TRAIL	4982	8743	Gene	Gene	patients|nmod|START_ENTITY associated|nsubjpass|patients type|acl:relcl|associated elevated|nmod|type elevated|nsubj|osteoprotegerin osteoprotegerin|appos|END_ENTITY	Serum osteoprotegerin and tumor necrosis factor related apoptosis inducing-ligand -LRB- TRAIL -RRB- are elevated in type 2 diabetic patients with albuminuria and serum osteoprotegerin is independently associated with the severity of diabetic_nephropathy .
24280212	0	osteoprotegerin	121,136	TRAIL	153,158	osteoprotegerin	TRAIL	4982	8743	Gene	Gene	factor-related|nmod|START_ENTITY necrosis|acl|factor-related affinity|nmod|necrosis overcomes|nsubj|affinity overcomes|dobj|resistance resistance|amod|END_ENTITY	Decreased affinity of recombinant human tumor necrosis factor-related apoptosis-inducing ligand -LRB- rhTRAIL -RRB- D269H/E195R to osteoprotegerin -LRB- OPG -RRB- overcomes TRAIL resistance mediated by the bone microenvironment .
25520884	0	osteoprotegerin	96,111	TRAIL	153,158	osteoprotegerin	TRAIL	4982	8743	Gene	Gene	Secretion|dep|START_ENTITY Cells|nsubj|Secretion Cells|nmod|Effects Effects|nmod|END_ENTITY	Rab25 Small GTPase Mediates Secretion of Tumor Necrosis Factor Receptor Superfamily Member 11b -LRB- osteoprotegerin -RRB- Protecting Cancer Cells from Effects of TRAIL .
10433211	0	osteoprotegerin	51,66	TRANCE	31,37	osteoprotegerin	TRANCE	18383(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Parathyroid_hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures : correlation with osteoclast-like cell formation .
11562486	0	osteoprotegerin	38,53	TRANCE	30,36	osteoprotegerin	TRANCE	4982	8600	Gene	Gene	cytokine|compound|START_ENTITY cytokine|compound|END_ENTITY	Multiple_myeloma disrupts the TRANCE / osteoprotegerin cytokine axis to trigger bone_destruction and promote tumor progression .
18565131	0	osteoprotegerin	17,32	Thrombin	0,8	osteoprotegerin	Thrombin	4982	2147	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3 ' - kinase/mammalian _ target_of_rapamycin pathway in human periodontal ligament cells .
21660951	0	osteoprotegerin	36,51	Trail	0,5	osteoprotegerin	Trail	4982	8743	Gene	Gene	release|nmod|START_ENTITY down-regulates|dobj|release down-regulates|nsubj|END_ENTITY	Trail down-regulates the release of osteoprotegerin -LRB- OPG -RRB- by primary stromal cells .
14994384	0	osteoprotegerin	55,70	Tumor_necrosis_factor-alpha	0,27	osteoprotegerin	Tumor necrosis factor-alpha	4982	7124	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha promotes the expression of osteoprotegerin in rheumatoid synovial fibroblasts .
21087777	0	osteoprotegerin	40,55	adiponectin	11,22	osteoprotegerin	adiponectin	4982	9370	Gene	Gene	levels|nmod|START_ENTITY associated|nsubjpass|levels associated|advcl|END_ENTITY	Similar to adiponectin , serum levels of osteoprotegerin are associated with obesity in healthy subjects .
22634178	0	osteoprotegerin	72,87	adiponectin	28,39	osteoprotegerin	adiponectin	4982	9370	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|regulation regulation|amod|17b-estradiol 17b-estradiol|nmod|END_ENTITY	Effects of 17b-estradiol on adiponectin regulation of the expression of osteoprotegerin and receptor_activator_of_nuclear_factor-kB_ligand .
22841521	0	osteoprotegerin	16,31	adiponectin	37,48	osteoprotegerin	adiponectin	4982	9370	Gene	Gene	START_ENTITY|nmod|C-reactive_protein C-reactive_protein|compound|END_ENTITY	A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive_protein -LRB- hsCRP -RRB- as a marker for insulin resistance .
15700136	0	osteoprotegerin	9,24	insulin	118,125	osteoprotegerin	insulin	4982	3630	Gene	Gene	START_ENTITY|dep|amounts amounts|nmod|END_ENTITY	Arterial osteoprotegerin : increased amounts in diabetes and modifiable synthesis from vascular smooth muscle cells by insulin and TNF-alpha .
16712667	0	osteoprotegerin	12,27	insulin	62,69	osteoprotegerin	insulin	4982	3630	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|steroids steroids|dep|END_ENTITY	Circulating osteoprotegerin is correlated with lipid profile , insulin sensitivity , adiponectin and sex steroids in an ageing male population .
17023086	0	osteoprotegerin	11,26	insulin	44,51	osteoprotegerin	insulin	4982	3630	Gene	Gene	Changes|nmod|START_ENTITY Changes|nmod|therapy therapy|compound|END_ENTITY	Changes of osteoprotegerin before and after insulin therapy in type 1 diabetic patients .
22841521	0	osteoprotegerin	16,31	insulin	113,120	osteoprotegerin	insulin	4982	3630	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|marker marker|nmod|resistance resistance|compound|END_ENTITY	A comparison of osteoprotegerin with adiponectin and high-sensitivity C-reactive_protein -LRB- hsCRP -RRB- as a marker for insulin resistance .
23695991	0	osteoprotegerin	49,64	insulin	19,26	osteoprotegerin	insulin	4982	3630	Gene	Gene	association|nmod|START_ENTITY association|nmod|resistance resistance|compound|END_ENTITY	The association of insulin resistance with serum osteoprotegerin in obese adolescents .
26036811	0	osteoprotegerin	42,57	insulin	15,22	osteoprotegerin	insulin	4982	3630	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	The effects of insulin and liraglutide on osteoprotegerin and vascular_calcification in vitro and in patients with type 2 diabetes .
16251181	0	osteoprotegerin	150,165	interleukin-4	88,101	osteoprotegerin	interleukin-4	18383(Tax:10090)	16189(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Inhibition Inhibition|acl|resorption resorption|nmod|END_ENTITY	Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway .
10469276	0	osteoprotegerin	14,29	osteoclastogenesis_inhibitory_factor	31,67	osteoprotegerin	osteoclastogenesis inhibitory factor	4982	4982	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of osteoprotegerin -LRB- osteoclastogenesis_inhibitory_factor -RRB- in cultures of human dental mesenchymal cells and epithelial cells .
17852826	0	osteoprotegerin	74,89	osteopontin	61,72	osteoprotegerin	osteopontin	4982	6696	Gene	Gene	activator|dep|START_ENTITY activator|compound|END_ENTITY	Biological variation and reference intervals for circulating osteopontin , osteoprotegerin , total soluble receptor activator of nuclear factor kappa B ligand and high-sensitivity C-reactive protein .
18612923	0	osteoprotegerin	35,50	osteopontin	22,33	osteoprotegerin	osteopontin	4982	6696	Gene	Gene	activator|dep|START_ENTITY activator|compound|END_ENTITY	Circulating levels of osteopontin , osteoprotegerin , total soluble receptor activator of nuclear factor-kappa B ligand , and high-sensitivity C-reactive protein in patients with active rheumatoid_arthritis randomized to etanercept alone or in combination with methotrexate .
26044505	0	osteoprotegerin	43,58	p38	73,76	osteoprotegerin	p38	18383(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|kinase kinase|amod|END_ENTITY	Resveratrol amplifies BMP __ -4 - stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts .
11454517	0	osteoprotegerin	91,106	parathyroid_hormone	6,25	osteoprotegerin	parathyroid hormone	4982	5741	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	Serum parathyroid_hormone , but not menopausal status , is associated with the expression of osteoprotegerin and RANKL mRNA in human bone samples .
11746511	0	osteoprotegerin	122,137	parathyroid_hormone	83,102	osteoprotegerin	parathyroid hormone	25341(Tax:10116)	24694(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression END_ENTITY|dobj|inhibition	Identification of signal transduction pathways and promoter sequences that mediate parathyroid_hormone 1-38 inhibition of osteoprotegerin gene expression .
16137047	0	osteoprotegerin	35,50	parathyroid_hormone	12,31	osteoprotegerin	parathyroid hormone	4982	5741	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of parathyroid_hormone on osteoprotegerin expression and osteoprotegerin_ligand and their related cytokines in human osteoblasts -RSB- .
14675140	0	osteoprotegerin	206,221	parathyroid_hormone-related_protein	14,49	osteoprotegerin	parathyroid hormone-related protein	4982	5744	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- , osteoclast_differentiation_factor -LRB- ODF -RRB- / receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- and osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- in ameloblastomas .
15544627	0	osteoprotegerin	113,128	receptor_activator_of_NF-kappaB_ligand	24,62	osteoprotegerin	receptor activator of NF-kappaB ligand	4982	8600	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Increased expression of receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- , its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn 's _ disease patients .
14675140	0	osteoprotegerin	206,221	receptor_activator_of_nuclear_factor-kappaB_ligand	99,149	osteoprotegerin	receptor activator of nuclear factor-kappaB ligand	4982	8600	Gene	Gene	START_ENTITY|nsubj|osteoclast_differentiation_factor osteoclast_differentiation_factor|dep|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- , osteoclast_differentiation_factor -LRB- ODF -RRB- / receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- and osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- in ameloblastomas .
17453373	0	osteoprotegerin	122,137	receptor_activator_of_nuclear_factor-kappaB_ligand	63,113	osteoprotegerin	receptor activator of nuclear factor-kappaB ligand	4982	8600	Gene	Gene	axis|compound|START_ENTITY axis|amod|END_ENTITY	Abnormal bone remodeling process is due to an imbalance in the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- axis in patients with solid tumors metastatic to the skeleton .
15327520	0	osteoprotegerin	69,84	receptor_activator_of_nuclear_factor-kappa_B_ligand	8,59	osteoprotegerin	receptor activator of nuclear factor-kappa B ligand	4982	8600	Gene	Gene	1-alpha|amod|START_ENTITY 1-alpha|amod|END_ENTITY	Role of receptor_activator_of_nuclear_factor-kappa_B_ligand -LRB- RANKL -RRB- , osteoprotegerin and macrophage protein 1-alpha -LRB- MIP-1a -RRB- in monoclonal_gammopathy_of_undetermined_significance -LRB- MGUS -RRB- .
24693367	0	osteoprotegerin	33,48	receptor_activator_of_nuclear_factor-kappa_B_ligand	61,112	osteoprotegerin	receptor activator of nuclear factor-kappa B ligand	4982	8600	Gene	Gene	serum|amod|START_ENTITY breastfeeding|nmod|serum Effect|acl|breastfeeding END_ENTITY|nsubj|Effect	Effect of breastfeeding on serum osteoprotegerin and soluble receptor_activator_of_nuclear_factor-kappa_B_ligand in full term neonates .
11393778	0	osteoprotegerin	91,106	receptor_activator_of_nuclear_factor_kappaB_ligand	37,87	osteoprotegerin	receptor activator of nuclear factor kappaB ligand	4982	8600	Gene	Gene	correlates|compound|START_ENTITY END_ENTITY|nmod|correlates	The ratio of messenger RNA levels of receptor_activator_of_nuclear_factor_kappaB_ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis .
14741739	0	osteoprotegerin	43,58	receptor_activator_of_nuclear_factor_kappaB_ligand	90,140	osteoprotegerin	receptor activator of nuclear factor kappaB ligand	18383(Tax:10090)	21943(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY activity|acl|induced activity|dep|involvement involvement|nmod|END_ENTITY	Cellular activity and signaling induced by osteoprotegerin in osteoclasts : involvement of receptor_activator_of_nuclear_factor_kappaB_ligand and MAPK .
15930166	0	osteoprotegerin	122,137	receptor_activator_of_nuclear_factor_kappaB_ligand	71,121	osteoprotegerin	receptor activator of nuclear factor kappaB ligand	4982	8600	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Alpha-lipoic_acid suppresses osteoclastogenesis despite increasing the receptor_activator_of_nuclear_factor_kappaB_ligand / osteoprotegerin ratio in human bone marrow stromal cells .
16828054	0	osteoprotegerin	20,35	receptor_activator_of_nuclear_factor_kappaB_ligand	126,176	osteoprotegerin	receptor activator of nuclear factor kappaB ligand	4982	8600	Gene	Gene	Characterization|nmod|START_ENTITY binding|nsubj|Characterization binding|nmod|resonance resonance|dep|role role|nmod|interactions interactions|nmod|END_ENTITY	Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance : role in the interactions with receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- and RANK .
18166509	0	osteoprotegerin	125,140	receptor_activator_of_nuclear_factor_kappaB_ligand	74,124	osteoprotegerin	receptor activator of nuclear factor kappaB ligand	25341(Tax:10116)	117516(Tax:10116)	Gene	Gene	ratio|compound|START_ENTITY ratio|amod|END_ENTITY	Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor_activator_of_nuclear_factor_kappaB_ligand / osteoprotegerin ratio .
10087294	0	osteotesticular_phosphatase	4,31	Esp	38,41	osteotesticular phosphatase	Esp	64576(Tax:10116)	64576(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Rat osteotesticular_phosphatase gene -LRB- Esp -RRB- : genomic structure and chromosome location .
12647290	0	osterix	38,45	Bone_morphogenetic_protein-2	0,28	osterix	Bone morphogenetic protein-2	170574(Tax:10090)	12156(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 enhances osterix gene expression in chondrocytes .
23185634	0	osterix	99,106	Matrix_metalloproteinase_13	0,27	osterix	Matrix metalloproteinase 13	170574(Tax:10090)	17386(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Matrix_metalloproteinase_13 -LRB- MMP13 -RRB- is a direct target of osteoblast-specific transcription factor osterix -LRB- Osx -RRB- in osteoblasts .
17623776	0	osterix	32,39	PIASxbeta	0,9	osterix	PIASxbeta	170574(Tax:10090)	17344(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts .
18494002	0	osterix	44,51	PTH	25,28	osterix	PTH	121340	5741	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Teriparatide -LRB- 1-34 human PTH -RRB- regulation of osterix during fracture repair .
16610234	0	osterix	30,37	Parathyroid_hormone	0,19	osterix	Parathyroid hormone	300260(Tax:10116)	24694(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Parathyroid_hormone regulates osterix and Runx2 mRNA expression predominantly through protein_kinase_A signaling in osteoblast-like cells .
20816666	0	osterix	74,81	Sclerostin	0,10	osterix	Sclerostin	170574(Tax:10090)	74499(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Sclerostin is a direct target of osteoblast-specific transcription factor osterix .
23682129	0	osterix	18,25	osterix	49,56	osterix	osterix	121340	121340	Gene	Gene	Regulation|nmod|START_ENTITY promoter|nsubj|Regulation promoter|nmod|END_ENTITY	Regulation of the osterix -LRB- Osx , Sp7 -RRB- promoter by osterix and its inhibition by parathyroid_hormone .
23682129	0	osterix	49,56	osterix	18,25	osterix	osterix	121340	121340	Gene	Gene	promoter|nmod|START_ENTITY promoter|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the osterix -LRB- Osx , Sp7 -RRB- promoter by osterix and its inhibition by parathyroid_hormone .
23682129	0	osterix	18,25	parathyroid_hormone	79,98	osterix	parathyroid hormone	121340	5741	Gene	Gene	Regulation|nmod|START_ENTITY promoter|nsubj|Regulation promoter|nmod|END_ENTITY	Regulation of the osterix -LRB- Osx , Sp7 -RRB- promoter by osterix and its inhibition by parathyroid_hormone .
23682129	0	osterix	49,56	parathyroid_hormone	79,98	osterix	parathyroid hormone	121340	5741	Gene	Gene	promoter|nmod|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the osterix -LRB- Osx , Sp7 -RRB- promoter by osterix and its inhibition by parathyroid_hormone .
14635104	0	otoferlin	58,67	OTOF	74,78	otoferlin	OTOF	9381	9381	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Auditory_neuropathy in patients carrying mutations in the otoferlin gene -LRB- OTOF -RRB- .
19250381	0	otoferlin	47,56	OTOF	63,67	otoferlin	OTOF	9381	9381	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identities and frequencies of mutations of the otoferlin gene -LRB- OTOF -RRB- causing DFNB9_deafness in Pakistan .
10223937	0	outer_membrane_protein	124,146	beta-lactamase	83,97	outer membrane protein	beta-lactamase	18157965	7872529(Tax:562)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Carbapenem resistance in Escherichia_coli associated with plasmid-determined CMY-4 beta-lactamase production and loss of an outer_membrane_protein .
9802884	0	ovalbumin	61,70	GM-CSF	0,6	ovalbumin	GM-CSF	282665(Tax:10090)	12981(Tax:10090)	Gene	Gene	allows|dobj|START_ENTITY allows|nsubj|expression expression|amod|END_ENTITY	GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice .
11293507	0	ovalbumin	57,66	Ovalbumin	0,9	ovalbumin	Ovalbumin	282665(Tax:10090)	282665(Tax:10090)	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Ovalbumin fused with diphtheria toxin protects mice from ovalbumin induced anaphylactic shock .
19171941	0	ovarian_tumor	35,48	Sex-lethal	62,72	ovarian tumor	Sex-lethal	31789(Tax:7227)	3772180(Tax:7227)	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Effects of Wolbachia_infection and ovarian_tumor mutations on Sex-lethal germline functioning in Drosophila .
20118424	0	oviductal_glycoprotein_1	21,45	OVGP1	47,52	oviductal glycoprotein 1	OVGP1	100008811(Tax:9986)	1502145(Tax:11027)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of the oviductal_glycoprotein_1 -LRB- OVGP1 -RRB- gene associated with embryo survival and development in the rabbit .
11983900	0	ovo	78,81	movo1	41,46	ovo	movo1	31429(Tax:7227)	18426(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	The LEF1/beta _ - catenin complex activates movo1 , a mouse homolog of Drosophila ovo required for epidermal appendage differentiation .
7748792	0	ovo	0,3	shavenbaby	144,154	ovo	shavenbaby	31429(Tax:7227)	31429(Tax:7227)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|END_ENTITY	ovo , a Drosophila gene required for ovarian development , is specifically expressed in the germline and shares most of its coding sequences with shavenbaby , a gene involved in embryo patterning .
21622876	0	ovulation_rate	129,143	bone_morphogenetic_protein_15	42,71	ovulation rate	bone morphogenetic protein 15	100689616	100052461(Tax:9796)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Effect of the FecX -LRB- R -RRB- polymorphism in the bone_morphogenetic_protein_15 gene on natural or equine chorionic gonadotropin-induced ovulation_rate and litter size in Rasa Aragonesa ewes and implications for on-farm application .
23404117	0	oxidation_resistance_1	28,50	MicroRNA-200b	0,13	oxidation resistance 1	MicroRNA-200b	170719(Tax:10090)	387243(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	MicroRNA-200b downregulates oxidation_resistance_1 -LRB- Oxr1 -RRB- expression in the retina of type 1 diabetes model .
23404117	0	oxidation_resistance_1	28,50	Oxr1	52,56	oxidation resistance 1	Oxr1	170719(Tax:10090)	170719(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MicroRNA-200b downregulates oxidation_resistance_1 -LRB- Oxr1 -RRB- expression in the retina of type 1 diabetes model .
21276203	0	oxidative_signal-inducible_1	77,105	Pto-interacting_1-4	31,50	oxidative signal-inducible 1	Pto-interacting 1-4	822119(Tax:3702)	819320(Tax:3702)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The Arabidopsis protein kinase Pto-interacting_1-4 is a common target of the oxidative_signal-inducible_1 and mitogen-activated protein kinases .
10719179	0	oxidized_protein_hydrolase	18,44	acylpeptide_hydrolase	70,91	oxidized protein hydrolase	acylpeptide hydrolase	327	327	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of oxidized_protein_hydrolase of human erythrocytes as acylpeptide_hydrolase .
22155709	0	oxidored_nitro_domain_containing_protein_1	27,69	NOR1	71,75	oxidored nitro domain containing protein 1	NOR1	127700	22038(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of oxidored_nitro_domain_containing_protein_1 -LRB- NOR1 -RRB- , in mouse tissues and in normal and cancerous human tissues .
11454679	0	oxoguanine_dna_glycosylase	74,100	OGG1	102,106	oxoguanine dna glycosylase	OGG1	18294(Tax:10090)	18294(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine_dna_glycosylase -LRB- OGG1 -RRB- gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice .
25450139	0	oxtr	72,76	oxytocin_receptor	48,65	oxtr	oxytocin receptor	5021	5021	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Preliminary evidence for the interaction of the oxytocin_receptor gene -LRB- oxtr -RRB- and face processing in differentiating prenatal smoking patterns .
11278871	0	oxysterol-binding_protein	54,79	OSBP2	81,86	oxysterol-binding protein	OSBP2	23762	23762	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular and biochemical characterization of a novel oxysterol-binding_protein -LRB- OSBP2 -RRB- highly expressed in retina .
12023275	0	oxysterol-binding_protein	84,109	Vesicle-associated_membrane_protein-associated_protein-A	0,56	oxysterol-binding protein	Vesicle-associated membrane protein-associated protein-A	5007	9218	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Vesicle-associated_membrane_protein-associated_protein-A -LRB- VAP-A -RRB- interacts with the oxysterol-binding_protein to modify export from the endoplasmic reticulum .
11470525	0	oxysterol_7_alpha-hydroxylase	36,65	Sp1	83,86	oxysterol 7 alpha-hydroxylase	Sp1	9420	6667	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of human oxysterol_7_alpha-hydroxylase gene -LRB- CYP7B1 -RRB- by Sp1 .
12029625	0	oxysterol_7alpha-hydroxylase	14,42	CYP7B1	44,50	oxysterol 7alpha-hydroxylase	CYP7B1	25429(Tax:10116)	25429(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of oxysterol_7alpha-hydroxylase -LRB- CYP7B1 -RRB- in primary cultures of rat hepatocytes .
12759897	0	oxysterol_7alpha-hydroxylase	14,42	CYP7B1	44,50	oxysterol 7alpha-hydroxylase	CYP7B1	25429(Tax:10116)	25429(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of oxysterol_7alpha-hydroxylase -LRB- CYP7B1 -RRB- in the rat .
11861666	0	oxysterol_binding_protein	19,44	ORP2	0,4	oxysterol binding protein	ORP2	5007	9885	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	ORP2 , a homolog of oxysterol_binding_protein , regulates cellular cholesterol metabolism .
9806908	0	oxysterol_binding_protein	22,47	OSBP	49,53	oxysterol binding protein	OSBP	100760367	100760367	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Cholesterol regulates oxysterol_binding_protein -LRB- OSBP -RRB- phosphorylation and Golgi localization in Chinese_hamster_ovary cells : correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol .
15635101	0	oxysterol_binding_protein	156,181	phosphatidylinositol_4-kinase_type-III_alpha	75,119	oxysterol binding protein	phosphatidylinositol 4-kinase type-III alpha	5007	5297	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	A plasma membrane pool of phosphatidylinositol_4-phosphate is generated by phosphatidylinositol_4-kinase_type-III_alpha : studies with the PH domains of the oxysterol_binding_protein and FAPP1 .
24118254	0	oxytocin	28,36	Annexin_A1	0,10	oxytocin	Annexin A1	5020	301	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Annexin_A1 complex mediates oxytocin vesicle transport .
22434086	0	oxytocin	75,83	ERb	4,7	oxytocin	ERb	18429(Tax:10090)	13983(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The ERb ligand 5a-androstane , 3b,17b-diol -LRB- 3b-diol -RRB- regulates hypothalamic oxytocin -LRB- Oxt -RRB- gene expression .
11554696	0	oxytocin	31,39	IL-1beta	10,18	oxytocin	IL-1beta	5020	3553	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of IL-1beta and IL-6 on oxytocin secretion in human uterine smooth muscle cells .
21154196	0	oxytocin	9,17	NPY	43,46	oxytocin	NPY	5020	4852	Gene	Gene	modulates|compound|START_ENTITY END_ENTITY|nsubj|modulates	Systemic oxytocin administration modulates NPY response to insulin-induced hypoglycemia in man .
20585395	0	oxytocin	23,31	OXTR	42,46	oxytocin	OXTR	5020	5021	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between oxytocin receptor -LRB- OXTR -RRB- gene polymorphisms and experimentally elicited social preferences .
22336563	0	oxytocin	46,54	OXTR	80,84	oxytocin	OXTR	5020	5021	Gene	Gene	associated|nmod|START_ENTITY associated|nmod|genes genes|compound|END_ENTITY	Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes .
22434086	0	oxytocin	75,83	Oxt	85,88	oxytocin	Oxt	18429(Tax:10090)	18429(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	The ERb ligand 5a-androstane , 3b,17b-diol -LRB- 3b-diol -RRB- regulates hypothalamic oxytocin -LRB- Oxt -RRB- gene expression .
10601979	0	oxytocin	24,32	RORalpha	65,73	oxytocin	RORalpha	18429(Tax:10090)	19883(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY Activation|nmod|promoter Activation|nmod|END_ENTITY	Activation of the mouse oxytocin promoter by the orphan receptor RORalpha .
17825097	0	oxytocin	30,38	estrogen_receptor_alpha	68,91	oxytocin	estrogen receptor alpha	5020	2099	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|nmod|END_ENTITY	The organizational effects of oxytocin on the central expression of estrogen_receptor_alpha and oxytocin in adulthood .
12684429	0	oxytocin	85,93	placental_leucine_aminopeptidase	17,49	oxytocin	placental leucine aminopeptidase	5020	4012	Gene	Gene	effect|nmod|START_ENTITY role|nmod|effect role|nmod|END_ENTITY	Possible role of placental_leucine_aminopeptidase in the antiproliferative effect of oxytocin in human endometrial_adenocarcinoma .
20382690	0	oxytocin	47,55	protein_kinase_C_alpha	61,83	oxytocin	protein kinase C alpha	5020	5578	Gene	Gene	START_ENTITY|nmod|manner manner|compound|END_ENTITY	Melatonin sensitizes human myometrial cells to oxytocin in a protein_kinase_C_alpha / extracellular-signal regulated kinase-dependent manner .
1486803	0	oxytocin-neurophysin_I	19,41	OXT	43,46	oxytocin-neurophysin I	OXT	5020	5020	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The human gene for oxytocin-neurophysin_I -LRB- OXT -RRB- is physically mapped to chromosome 20p13 by in situ hybridization .
10735599	0	oxytocin_receptor	38,55	Interleukin-1_beta	0,18	oxytocin receptor	Interleukin-1 beta	5021	3553	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	Interleukin-1_beta down-regulates the oxytocin_receptor in cultured uterine smooth muscle cells .
19376182	0	oxytocin_receptor	25,42	OXTR	49,53	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations between the oxytocin_receptor gene -LRB- OXTR -RRB- and affect , loneliness and intelligence in normal subjects .
20094064	0	oxytocin_receptor	19,36	OXTR	38,42	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the oxytocin_receptor -LRB- OXTR -RRB- gene polymorphisms with autism_spectrum_disorder -LRB- ASD -RRB- in the Japanese population .
20347913	0	oxytocin_receptor	39,56	OXTR	58,62	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence that genetic variation in the oxytocin_receptor -LRB- OXTR -RRB- gene influences social cognition in ADHD .
21484202	0	oxytocin_receptor	15,32	OXTR	34,38	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of oxytocin_receptor -LRB- OXTR -RRB- gene variants with multiple phenotype domains of autism_spectrum_disorder .
22084107	0	oxytocin_receptor	26,43	OXTR	45,49	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Thin-slicing study of the oxytocin_receptor -LRB- OXTR -RRB- gene and the evaluation and expression of the prosocial disposition .
22123970	0	oxytocin_receptor	7,24	OXTR	31,35	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Common oxytocin_receptor gene -LRB- OXTR -RRB- polymorphism and social support interact to reduce stress in humans .
22357335	0	oxytocin_receptor	24,41	OXTR	61,65	oxytocin receptor	OXTR	5021	5021	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	The association between oxytocin_receptor gene polymorphism -LRB- OXTR -RRB- and trait empathy .
22809402	0	oxytocin_receptor	25,42	OXTR	49,53	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations between the oxytocin_receptor gene -LRB- OXTR -RRB- and `` mind-reading '' in humans -- an exploratory study .
23470776	0	oxytocin_receptor	22,39	OXTR	46,50	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Environmental stress , oxytocin_receptor gene -LRB- OXTR -RRB- polymorphism , and mental health following collective stress .
23547247	0	oxytocin_receptor	13,30	OXTR	37,41	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variation in oxytocin_receptor gene -LRB- OXTR -RRB- polymorphisms is associated with emotional and behavioral reactions to betrayal .
23562248	0	oxytocin_receptor	28,45	OXTR	52,56	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The association between the oxytocin_receptor gene -LRB- OXTR -RRB- and hypnotizability .
24223720	0	oxytocin_receptor	4,21	OXTR	28,32	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The oxytocin_receptor gene -LRB- OXTR -RRB- in relation to state levels of loneliness in adolescence : evidence for micro-level gene-environment interactions .
24348360	0	oxytocin_receptor	40,57	OXTR	64,68	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Navigating the complex path between the oxytocin_receptor gene -LRB- OXTR -RRB- and cooperation : an endophenotype approach .
24367110	0	oxytocin_receptor	27,44	OXTR	51,55	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	Common polymorphism in the oxytocin_receptor gene -LRB- OXTR -RRB- is associated with human social recognition skills .
24485285	0	oxytocin_receptor	24,41	OXTR	43,47	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the oxytocin_receptor -LRB- OXTR -RRB- gene and mesolimbic responses to rewards .
24916666	0	oxytocin_receptor	24,41	OXTR	43,47	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between the oxytocin_receptor -LRB- OXTR -RRB- gene and children 's social cognition at 18 months .
25092245	0	oxytocin_receptor	4,21	OXTR	28,32	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The oxytocin_receptor gene -LRB- OXTR -RRB- is associated with autism_spectrum_disorder : a meta-analysis .
25264479	0	oxytocin_receptor	25,42	OXTR	44,48	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the oxytocin_receptor -LRB- OXTR -RRB- gene is associated with Asperger_Syndrome .
26178189	0	oxytocin_receptor	9,26	OXTR	33,37	oxytocin receptor	OXTR	5021	5021	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	A common oxytocin_receptor gene -LRB- OXTR -RRB- polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans .
26250573	0	oxytocin_receptor	70,87	OXTR	94,98	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Rigorous tests of gene-environment interactions in a lab study of the oxytocin_receptor gene -LRB- OXTR -RRB- , alcohol exposure , and aggression .
26250573	0	oxytocin_receptor	70,87	OXTR	94,98	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Rigorous tests of gene-environment interactions in a lab study of the oxytocin_receptor gene -LRB- OXTR -RRB- , alcohol exposure , and aggression .
26377392	0	oxytocin_receptor	36,53	OXTR	55,59	oxytocin receptor	OXTR	5021	5021	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Myometrial contractility influences oxytocin_receptor -LRB- OXTR -RRB- expression in term trophoblast cells obtained from the maternal surface of the human placenta .
27081536	0	oxytocin_receptor	29,46	OXTR	48,52	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel rare variations of the oxytocin_receptor -LRB- OXTR -RRB- gene in autism_spectrum_disorder individuals .
27082423	0	oxytocin_receptor	38,55	OXTR	57,61	oxytocin receptor	OXTR	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Erratum : Novel rare variations of the oxytocin_receptor -LRB- OXTR -RRB- gene in autism_spectrum_disorder individuals .
22967062	0	oxytocin_receptor	26,43	Oxtr	50,54	oxytocin receptor	Oxtr	18430(Tax:10090)	18430(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Mice heterozygous for the oxytocin_receptor gene -LRB- Oxtr -LRB- + / - -RRB- -RRB- show impaired_social_behaviour but not increased_aggression or cognitive inflexibility : evidence of a selective haploinsufficiency gene effect .
20670427	0	oxytocin_receptor	33,50	TNFalpha	96,104	oxytocin receptor	TNFalpha	5021	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|Regulation Regulation|nmod|END_ENTITY	Expression and activation of the oxytocin_receptor in airway smooth muscle cells : Regulation by TNFalpha and IL-13 .
11896597	0	oxytocin_receptor	26,43	caveolin-1	47,57	oxytocin receptor	caveolin-1	5021	857	Gene	Gene	START_ENTITY|nmod|domains domains|amod|END_ENTITY	Localization of the human oxytocin_receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response .
25450139	0	oxytocin_receptor	48,65	oxtr	72,76	oxytocin receptor	oxtr	5021	5021	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Preliminary evidence for the interaction of the oxytocin_receptor gene -LRB- oxtr -RRB- and face processing in differentiating prenatal smoking patterns .
12569180	0	oxytocinase	62,73	Interleukin-1beta	0,17	oxytocinase	Interleukin-1beta	4012	3553	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Interleukin-1beta stimulates placental_leucine_aminopeptidase / oxytocinase expression in BeWo choriocarcinoma cells .
1168550	0	oxytocinase	53,64	aminopeptidase	74,88	oxytocinase	aminopeptidase	4012	10404	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	A rapid and specific method for the determination of oxytocinase -LRB- cystine aminopeptidase -RRB- activity using continuous flow analysis and S-benzyl-L-cysteine-p-nitroanilide as substrate .
1421209	0	oxytocinase	26,37	aminopeptidase	47,61	oxytocinase	aminopeptidase	4012	10404	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition of human serum oxytocinase -LRB- cystine aminopeptidase , E. C. 3.4.11.3 -RRB- by GnRH peptides .
3186091	0	oxytocinase	40,51	aminopeptidase	24,38	oxytocinase	aminopeptidase	4012	10404	Gene	Gene	Change|appos|START_ENTITY Change|nmod|END_ENTITY	Change in plasma cystyl aminopeptidase -LRB- oxytocinase -RRB- between 30-34 weeks ' gestation as a predictor of pregnancy-induced hypertension .
970009	0	oxytocinase	50,61	aminopeptidase	28,42	oxytocinase	aminopeptidase	4012	10404	Gene	Gene	Determination|appos|START_ENTITY Determination|nmod|END_ENTITY	-LSB- Determination of L-cystine aminopeptidase -LRB- serum oxytocinase , EC 3.4.1.2 -RRB- during normal pregnancy -RSB- .
12614948	0	oxytocinase	101,112	aminopeptidase_A	32,48	oxytocinase	aminopeptidase A	4012	2028	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Ultrastructural localization of aminopeptidase_A / angiotensinase and placental_leucine_aminopeptidase / oxytocinase in chorionic villi of human placenta .
11389728	0	oxytocinase	47,58	placental_leucine_aminopeptidase	14,46	oxytocinase	placental leucine aminopeptidase	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of placental_leucine_aminopeptidase / oxytocinase in neuronal cells and its action on neuronal peptides .
11481040	0	oxytocinase	141,152	placental_leucine_aminopeptidase	108,140	oxytocinase	placental leucine aminopeptidase	4012	4012	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Genomic organization of the human adipocyte-derived_leucine_aminopeptidase gene and its relationship to the placental_leucine_aminopeptidase / oxytocinase gene .
12569180	0	oxytocinase	62,73	placental_leucine_aminopeptidase	29,61	oxytocinase	placental leucine aminopeptidase	4012	4012	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Interleukin-1beta stimulates placental_leucine_aminopeptidase / oxytocinase expression in BeWo choriocarcinoma cells .
1731608	0	oxytocinase	60,71	placental_leucine_aminopeptidase	24,56	oxytocinase	placental leucine aminopeptidase	4012	4012	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human placental_leucine_aminopeptidase as oxytocinase .
9733056	0	oxytocinase	69,80	placental_leucine_aminopeptidase	36,68	oxytocinase	placental leucine aminopeptidase	4012	4012	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of placental_leucine_aminopeptidase / oxytocinase in normal human placental , fetal and adult tissues .
18234018	0	p-53	85,89	PCNA	79,83	p-53	PCNA	7157	5111	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Molecular markers of cancer in cartilaginous_fish : immunocytochemical study of PCNA , p-53 , myc and ras expression in neoplastic and hyperplastic tissues from free ranging blue sharks , Prionace glauca -LRB- L. -RRB- .
24650887	0	p-c-JUN_and_JNK	219,234	IL-6	138,142	p-c-JUN and JNK	IL-6	26419(Tax:10090)	16193(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
17354009	0	p-glycoprotein	27,41	ABCB1	20,25	p-glycoprotein	ABCB1	5243	5243	Gene	Gene	impact|appos|START_ENTITY impact|nmod|END_ENTITY	Potential impact of ABCB1 -LRB- p-glycoprotein -RRB- polymorphisms on avermectin toxicity in humans .
19170519	0	p-glycoprotein	93,107	ABCG2	69,74	p-glycoprotein	ABCG2	5243	9429	Gene	Gene	tariquidar|amod|START_ENTITY derived|nmod|tariquidar derived|nsubj|inhibitors inhibitors|appos|END_ENTITY	Potent and selective inhibitors of breast_cancer_resistance_protein -LRB- ABCG2 -RRB- derived from the p-glycoprotein -LRB- ABCB1 -RRB- modulator tariquidar .
11368976	0	p-glycoprotein	54,68	Cyclosporin_A	0,13	p-glycoprotein	Cyclosporin A	67078(Tax:10090)	71991(Tax:10090)	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Cyclosporin_A inhibits the extrusion pump function of p-glycoprotein in the inner ear of mice treated with vinblastine and doxorubicin .
9618515	0	p-glycoprotein	27,41	MDR-1	43,48	p-glycoprotein	MDR-1	5243	5243	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	A physiologic function for p-glycoprotein -LRB- MDR-1 -RRB- during the migration of dendritic cells from skin via afferent lymphatic vessels .
20600890	0	p-glycoprotein	98,112	MRP2	125,129	p-glycoprotein	MRP2	5243	1244	Gene	Gene	ABCB1|appos|START_ENTITY ABCB1|appos|END_ENTITY	Commonly used nonionic surfactants interact differently with the human efflux transporters ABCB1 -LRB- p-glycoprotein -RRB- and ABCC2 -LRB- MRP2 -RRB- .
17356567	0	p-glycoprotein	62,76	Mdr1	51,55	p-glycoprotein	Mdr1	67078(Tax:10090)	18669(Tax:10090)	Gene	Gene	ABCB1|dep|START_ENTITY ABCB1|appos|END_ENTITY	The antidepressant desipramine requires the ABCB1 -LRB- Mdr1 -RRB- - type p-glycoprotein to upregulate the glucocorticoid receptor in mice .
22879045	0	p-glycoprotein	69,83	Pgp	85,88	p-glycoprotein	Pgp	5243	5243	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	PET imaging of the impact of extracellular pH and MAP kinases on the p-glycoprotein -LRB- Pgp -RRB- activity .
10661503	0	p-glycoprotein	20,34	mdr1a	14,19	p-glycoprotein	mdr1a	67078(Tax:10090)	18671(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood-inner ear barrier in mice .
12932699	0	p-glycoprotein	101,115	multixenobiotic_resistance	126,152	p-glycoprotein	multixenobiotic resistance	5243	9429	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Mussel blood cells , resistant to the cytotoxic effects of okadaic_acid , do not express cell membrane p-glycoprotein activity -LRB- multixenobiotic_resistance -RRB- .
18729196	0	p-glycoprotein	129,143	p38	162,165	p-glycoprotein	p38	287115(Tax:10116)	81649(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Acidosis induces multi-drug resistance in rat prostate_cancer cells -LRB- AT1 -RRB- in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38 .
21445777	0	p-glycoprotein	49,63	p38	115,118	p-glycoprotein	p38	287115(Tax:10116)	81649(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY increases|dobj|activity increases|nmod|tumors tumors|nmod|vivo vivo|nmod|END_ENTITY	Hypoxia-induced extracellular acidosis increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway .
9701587	0	p-hydroxyphenylpyruvate_dioxygenase	72,107	pds1	35,39	p-hydroxyphenylpyruvate dioxygenase	pds1	837168(Tax:3702)	837168(Tax:3702)	Gene	Gene	mutation|nmod|START_ENTITY mutation|amod|END_ENTITY	Complementation of the Arabidopsis pds1 mutation with the gene encoding p-hydroxyphenylpyruvate_dioxygenase .
22681853	0	p-nitrophenol	17,30	PNP	32,35	p-nitrophenol	PNP	4860	4860	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Branching of the p-nitrophenol -LRB- PNP -RRB- degradation pathway in burkholderia sp .
11944912	0	p-selectin	23,33	Thrombopoietin	0,14	p-selectin	Thrombopoietin	6403	7066	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombopoietin induces p-selectin expression on platelets and subsequent platelet/leukocyte interactions .
19084499	0	p/CAF	18,23	HOXA10	0,6	p/CAF	HOXA10	8850	3206	Gene	Gene	activity|compound|START_ENTITY suppresses|dobj|activity suppresses|nsubj|END_ENTITY	HOXA10 suppresses p/CAF promoter activity via three consecutive TTAT units in human endometrial stromal cells .
9192892	0	p/CIP	33,38	CBP	45,48	p/CIP	CBP	8202;102157402	1387	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function .
22965878	0	p0071	26,31	Folliculin	0,10	p0071	Folliculin	227937(Tax:10090)	216805(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Folliculin interacts with p0071 -LRB- plakophilin-4 -RRB- and deficiency is associated with disordered RhoA signalling , epithelial polarization and cytokinesis .
23139756	0	p0071	114,119	Folliculin	0,10	p0071	Folliculin	8502	201163	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Folliculin , the product of the Birt-Hogg-Dube tumor suppressor gene , interacts with the adherens junction protein p0071 to regulate cell-cell adhesion .
8937994	0	p0071	63,68	armadillo	38,47	p0071	armadillo	8502	1499	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	Cloning and characterization of a new armadillo family member , p0071 , associated with the junctional plaque : evidence for a subfamily of closely related proteins .
10092585	0	p0071	86,91	presenilin_1	50,62	p0071	presenilin 1	8502	5663	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Alzheimer 's _ disease-related presenilin_1 with armadillo protein p0071 .
17634229	0	p10	48,51	Gag	44,47	p10	Gag	6281	1491923(Tax:11886)	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Overlapping roles of the Rous_sarcoma_virus Gag p10 domain in nuclear export and virion core morphology .
18603592	0	p100	0,4	AT1R	15,19	p100	SND1	27044	27044	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	p100 increases AT1R expression through interaction with AT1R 3 ' - UTR .
15627504	0	p100	4,8	EBNA-2	9,15	p100	EBNA-2	4940	17494192	Gene	Gene	coactivator|amod|START_ENTITY coactivator|compound|END_ENTITY	The p100 EBNA-2 coactivator : a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle .
15140882	0	p100	13,17	NF-kappaB-inducing_kinase	32,57	p100	NF-kappaB-inducing kinase	4791	9020	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Induction of p100 processing by NF-kappaB-inducing_kinase involves docking IkappaB_kinase_alpha -LRB- IKKalpha -RRB- to p100 and IKKalpha-mediated phosphorylation .
9529131	0	p100	14,18	NFKB2	20,25	p100	NFKB2	4791	4791	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of p100 -LRB- NFKB2 -RRB- expression in human monocytes in response to inflammatory mediators and lymphokines .
12234934	0	p100	18,22	STAT6	44,49	p100	STAT6	27044	6778	Gene	Gene	START_ENTITY|nmod|coactivator coactivator|nmod|END_ENTITY	Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II .
25305492	0	p100	0,4	c-Rel	38,43	p100	c-Rel	4791	5966	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	p100 , a precursor of NF-kB2 , inhibits c-Rel and reduces the expression of IL-23 in dendritic cells .
7615637	0	p100	30,34	p120	0,4	p100	p120	72119(Tax:10090)	12388(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|appos|protein	p120 , a p120-related protein -LRB- p100 -RRB- , and the cadherin/catenin complex .
17576664	0	p100	37,41	snRNP	57,62	p100	snRNP	27044	57819	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|proteins proteins|compound|END_ENTITY	Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome .
16980301	0	p105	75,79	Arrestin-2	0,10	p105	Arrestin-2	4790	408	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	Arrestin-2 and G_protein-coupled_receptor_kinase_5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages .
12871932	0	p105	54,58	Glycogen_synthase_kinase-3_beta	0,31	p105	Glycogen synthase kinase-3 beta	4790	2932	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase-3_beta regulates NF-kappa_B1 / p105 stability .
17124531	0	p105	66,70	IkappaBalpha	35,47	p105	IkappaBalpha	4790	4792	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn_disease and ulcerative_colitis .
8183915	0	p105	62,66	NF-kappa_B	67,77	p105	NF-kappa B	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa_B gene generates I kappa B_gamma isoforms with different inhibitory activities .
19524538	0	p105	29,33	Nfkb1	4,9	p105	Nfkb1	4790	4790	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes .
19460845	0	p105	75,79	Platelet-activating_factor	0,26	p105	Platelet-activating factor	18033(Tax:10090)	109585(Tax:10090)	Gene	Gene	processing|nmod|START_ENTITY induces|dobj|processing induces|nsubj|END_ENTITY	Platelet-activating_factor induces the processing of nuclear factor-kappaB p105 into p50 , which mediates acute bowel_injury in mice .
8414497	0	p105	60,64	Tax	15,18	p105	Tax	4790	6900	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	HTLV-I encoded Tax in association with NF-kappa_B precursor p105 enhances nuclear localization of NF-kappa_B_p50 and p65 in transfected cells .
8900374	0	p105	25,29	erbB-2	30,36	p105	erbB-2	4790	2064	Gene	Gene	levels|nmod|START_ENTITY levels|dep|END_ENTITY	Elevated serum levels of p105 -LRB- erbB-2 -RRB- in patients with advanced-stage prostatic_adenocarcinoma .
7546052	0	p105	78,82	proliferation-associated_nuclear_antigen	36,76	p105	proliferation-associated nuclear antigen	4790	4790	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Flow cytometric characterization of proliferation-associated_nuclear_antigen -LRB- p105 -RRB- during the cell cycle in normal lymphocytes and promyelocytic_leukemia cells -LRB- HL-60 -RRB- .
8910512	0	p107	33,37	B-MYB	47,52	p107	B-MYB	5933	4605	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	The retinoblastoma family member p107 binds to B-MYB and suppresses its autoregulatory activity .
12439743	0	p107	101,105	B-Myb	0,5	p107	B-Myb	5933	4605	Gene	Gene	domain|nmod|START_ENTITY interacting|nmod|domain overcomes|advcl|interacting overcomes|nsubj|END_ENTITY	B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107 .
12147683	0	p107	93,97	B-myb	2,7	p107	B-myb	19650(Tax:10090)	17865(Tax:10090)	Gene	Gene	E2F|amod|START_ENTITY facilitates|nmod|E2F facilitates|nsubj|site site|amod|END_ENTITY	A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes .
7958924	0	p107	75,79	E2F-4	0,5	p107	E2F-4	5933	1874	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	E2F-4 , a new member of the E2F transcription factor family , interacts with p107 .
7958925	0	p107	87,91	E2F-4	0,5	p107	E2F-4	5933	1874	Gene	Gene	activity|nmod|START_ENTITY has|dobj|activity has|nsubj|END_ENTITY	E2F-4 , a new member of the E2F gene family , has oncogenic activity and associates with p107 in vivo .
8657117	0	p107	28,32	E2F-4	0,5	p107	E2F-4	5933	1874	Gene	Gene	p130|nmod|START_ENTITY switches|nmod|p130 switches|nsubj|END_ENTITY	E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry .
8146655	0	p107	72,76	Myc	31,34	p107	Myc	5933	4609	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Binding and suppression of the Myc transcriptional activation domain by p107 .
20713602	0	p107	44,48	PGC-1alpha	63,73	p107	PGC-1alpha	19650(Tax:10090)	19017(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Oxidative status of muscle is determined by p107 regulation of PGC-1alpha .
8076603	0	p107	50,54	c-Myc	15,20	p107	c-Myc	5933	4609	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation .
10329431	0	p107	197,201	cyclin_A	202,210	p107	cyclin A	5933	890	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	DP1 phosphorylation in multimeric complexes : weaker interaction with cyclin_A through the E2F1 cyclin_A binding domain leads to more efficient phosphorylation than stronger interaction through the p107 cyclin_A binding domain .
1532457	0	p107	15,19	cyclin_A	25,33	p107	cyclin A	5933	890	Gene	Gene	START_ENTITY|nmod|independent independent|compound|END_ENTITY	Interaction of p107 with cyclin_A independent of complex_formation_with_viral_oncoproteins .
2338340	0	p11	65,68	SPI1	35,39	p11	SPI1	6281	6688	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of the human oncogene SPI1 on chromosome 11 , region p11 .22 .
26577667	0	p11	0,3	mGluR5	42,48	p11	mGluR5	8909	14805(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|localization localization|nmod|END_ENTITY	p11 regulates the surface localization of mGluR5 .
21390257	0	p110	9,13	CD38	40,44	p110	CD38	18706(Tax:10090)	12494(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The PI3K p110 regulates expression of CD38 on regulatory T cells .
19635798	0	p110	0,4	CUX1	5,9	p110	CUX1	1523	1523	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin .
19738070	0	p110	34,38	CUX1	39,43	CUX1	CUX1	13047(Tax:10090)	13047(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|compound|END_ENTITY	Mouse_mammary_tumor_virus p75 and p110 CUX1 transgenic_mice develop mammary_tumors of various histologic types .
23590133	0	p110	45,49	CUX1	50,54	p110	CUX1	1523	1523	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Long-range transcriptional regulation by the p110 CUX1 homeodomain protein on the ENCODE array .
26047657	0	p110	20,24	PTBP1	0,5	p110	PTBP1	9733	5725	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas .
22375552	0	p110	37,41	TNFa	63,67	p110	TNFa	100616443	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Isoform-selective induction of human p110 PI3K expression by TNFa : identification of a new and inducible PIK3CD promoter .
21827948	0	p110	42,46	p85a	66,70	p110	p85a	9733	5295	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Dynamics of the phosphoinositide 3-kinase p110 interaction with p85a and membranes reveals aspects of regulation distinct from p110a .
18653476	0	p110-alpha	16,26	phosphatidylinositol-3-kinase	38,67	p110-alpha	phosphatidylinositol-3-kinase	5290	5290	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport .
16775835	0	p110_alpha	47,57	VEGF	71,75	p110 alpha	VEGF	5290	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of angiogenesis and tumor growth by p110_alpha and AKT1 via VEGF expression .
20667469	0	p110a	11,16	Akt	46,49	p110a	Akt	5290	207	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	PI3-kinase p110a mediates b1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading .
26581613	0	p110a	54,59	PIK3CA	86,92	p110a	PIK3CA	5290	5290	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Increased Expression of Phosphatidylinositol 3-Kinase p110a and Gene Amplification of PIK3CA in Nasopharyngeal_Carcinoma .
25915540	0	p110a	30,35	c-Myc	105,110	p110a	c-Myc	5290	4609	Gene	Gene	Expression|amod|START_ENTITY Expression|acl|END_ENTITY	The Phosphoinositide 3-Kinase p110a Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma .
25915540	0	p110a	30,35	c-Myc	105,110	p110a	c-Myc	5290	4609	Gene	Gene	Expression|amod|START_ENTITY Expression|acl|END_ENTITY	The Phosphoinositide 3-Kinase p110a Isoform Regulates Leukemia Inhibitory Factor Receptor Expression via c-Myc and miR-125b to Promote Cell Proliferation in Medulloblastoma .
25471065	0	p110a	24,29	miR-378	8,15	p110a	miR-378	18706(Tax:10090)	723889(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Hepatic miR-378 targets p110a and controls glucose and lipid homeostasis by modulating hepatic insulin signalling .
19679877	0	p110alpha	35,44	phosphoinositide_3-kinase	8,33	p110alpha	phosphoinositide 3-kinase	18706(Tax:10090)	18708(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Reduced phosphoinositide_3-kinase -LRB- p110alpha -RRB- activation increases the susceptibility to atrial_fibrillation .
25800850	0	p110b	43,48	Rab5	22,26	p110b	Rab5	5291	5868	Gene	Gene	Site|nmod|START_ENTITY Site|compound|END_ENTITY	Identification of the Rab5 Binding Site in p110b : Assays for PI3Kb Binding to Rab5 .
18780892	0	p110beta	26,34	Phosphoinositide_3-kinase	0,25	p110beta	Phosphoinositide 3-kinase	74769(Tax:10090)	18708(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Phosphoinositide_3-kinase p110beta activity : key role in metabolism and mammary gland cancer but not development .
18544649	0	p110beta	4,12	phosphoinositide_3-kinase	24,49	p110beta	phosphoinositide 3-kinase	74769(Tax:10090)	18708(Tax:10090)	Gene	Gene	isoform|amod|START_ENTITY isoform|nmod|signals signals|amod|END_ENTITY	The p110beta isoform of phosphoinositide_3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma .
12634853	0	p115	31,35	GBF1	51,55	p115	GBF1	8615	8729	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The membrane-tethering protein p115 interacts with GBF1 , an ARF guanine-nucleotide-exchange factor .
11852792	0	p115	24,28	Indy	19,23	p115	Indy	31698(Tax:7227)	40049(Tax:7227)	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	-LSB- Identification of Indy -LRB- p115 -RRB- mutation in the Na + - dicarboxylate transporter gene in Drosophila_melanogaster -RSB- .
25904324	0	p115	102,106	Phospholipase_C_gamma_1	0,23	p115	Phospholipase C gamma 1	8615	5335	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Phospholipase_C_gamma_1 regulates early secretory trafficking and cell migration via interaction with p115 .
15258251	0	p115RhoGEF	77,87	Galpha13	50,58	p115RhoGEF	Galpha13	9138;9181	10672	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated_RhoGEF .
9641915	0	p115_RhoGEF	0,11	Galpha12	45,53	p115 RhoGEF	Galpha12	9138;9181	2768	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	p115_RhoGEF , a GTPase activating protein for Galpha12 and Galpha13 .
9197417	0	p11_and_14-3-3	64,78	PCTAIRE-1	21,30	p11 and 14-3-3	PCTAIRE-1	20194(Tax:10090)	18555(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|nmod|proteins	The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11_and_14-3-3 proteins .
21085616	0	p12	26,29	Gag	4,7	p12	Gag	69745(Tax:10090)	17276(Tax:10090)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	The Gag cleavage product , p12 , is a functional constituent of the murine leukemia virus pre-integration complex .
9148968	0	p12	69,72	caspase-3	81,90	p12	caspase-3	56655	836	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	A sequential two-step mechanism for the production of the mature p17 : p12 form of caspase-3 in vitro .
9654073	0	p120	96,100	58-kDa_microspherule_protein	4,32	p120	58-kDa microspherule protein	4839	10445	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The 58-kDa_microspherule_protein -LRB- MSP58 -RRB- , a nucleolar protein , interacts with nucleolar protein p120 .
10708762	0	p120	84,88	GAP	89,92	p120	GAP	1500	1500	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Identification of a novel protein complex containing annexin_VI , Fyn , Pyk2 , and the p120 -LRB- GAP -RRB- C2 domain .
9211983	0	p120	36,40	HSRP1	56,61	p120	HSRP1	4839	3839	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human proliferation-related protein p120 interacts with HSRP1 .
10207085	0	p120	12,16	Kaiso	37,42	p120	Kaiso	1500	56805(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The catenin p120 -LRB- ctn -RRB- interacts with Kaiso , a novel BTB/POZ domain zinc finger transcription factor .
12087177	0	p120	4,8	Kaiso	30,35	p120	Kaiso	1500	56805(Tax:10090)	Gene	Gene	START_ENTITY|dep|partner partner|acl:relcl|protein protein|nsubj|END_ENTITY	The p120 -LRB- ctn -RRB- - binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated_CpG_dinucleotides .
17050009	0	p120	35,39	Kaiso	74,79	p120	Kaiso	12388(Tax:10090)	56805(Tax:10090)	Gene	Gene	ctn|amod|START_ENTITY factor|nsubj|ctn factor|dobj|END_ENTITY	Dancing in and out of the nucleus : p120 -LRB- ctn -RRB- and the transcription factor Kaiso .
10022880	0	p120	73,77	RasGAP	52,58	p120	RasGAP	36499(Tax:7227)	32569(Tax:7227)	Gene	Gene	protein|amod|START_ENTITY homolog|nmod|protein END_ENTITY|appos|homolog	Control of growth and differentiation by Drosophila RasGAP , a homolog of p120 Ras-GTPase-activating protein .
17188236	0	p120	42,46	RasGAP	47,53	p120	RasGAP	1500	5921	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	High resolution crystal structures of the p120 RasGAP SH3 domain .
20974127	0	p120	81,85	RhoA	152,156	p120	RhoA	1500	387	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|acl|induced induced|nmod|kinases kinases|nmod|mechanism mechanism|compound|END_ENTITY	Ga -LRB- 12 -RRB- binds to the N-terminal regulatory domain of p120 -LRB- ctn -RRB- , and downregulates p120 -LRB- ctn -RRB- tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism .
24995336	0	p120	0,4	RhoA	62,66	p120	RhoA	1500	387	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	p120 modulates LPS-induced NF-kB activation partially through RhoA in bronchial epithelial cells .
1334250	0	p120	0,4	beta-catenin	117,129	p120	beta-catenin	1500	1499	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	p120 , a novel substrate of protein tyrosine kinase receptors and of p60v-src , is related to cadherin-binding factors beta-catenin , plakoglobin and armadillo .
20974127	0	p120	81,85	ctn	86,89	p120	ctn	1500	1500	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Ga -LRB- 12 -RRB- binds to the N-terminal regulatory domain of p120 -LRB- ctn -RRB- , and downregulates p120 -LRB- ctn -RRB- tyrosine phosphorylation induced by Src family kinases via a RhoA independent mechanism .
7615637	0	p120	0,4	p100	30,34	p120	p100	12388(Tax:10090)	72119(Tax:10090)	Gene	Gene	START_ENTITY|appos|protein protein|appos|END_ENTITY	p120 , a p120-related protein -LRB- p100 -RRB- , and the cadherin/catenin complex .
21670201	0	p120-catenin	94,106	CK1	59,62	p120-catenin	CK1	1500	122011	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Wnt controls the transcriptional activity of Kaiso through CK1 - dependent phosphorylation of p120-catenin .
26905970	0	p120-catenin	94,106	CK1	59,62	p120-catenin	CK1	1500	3848	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Wnt controls the transcriptional activity of Kaiso through CK1 - dependent phosphorylation of p120-catenin .
20460685	0	p120-catenin	0,12	FOXC2	51,56	p120-catenin	FOXC2	12388(Tax:10090)	14234(Tax:10090)	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|END_ENTITY	p120-catenin is transcriptionally downregulated by FOXC2 in non-small_cell_lung_cancer cells .
23212915	0	p120-catenin	58,70	Neural_Wiskott-Aldrich_syndrome_protein	0,39	p120-catenin	Neural Wiskott-Aldrich syndrome protein	1500	8976	Gene	Gene	interaction|amod|START_ENTITY END_ENTITY|dep|interaction	Neural_Wiskott-Aldrich_syndrome_protein -LRB- N-WASP -RRB- - mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions .
25015829	0	p120-catenin	22,34	TLR4	52,56	p120-catenin	TLR4	12388(Tax:10090)	21898(Tax:10090)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Differential role for p120-catenin in regulation of TLR4 signaling in macrophages .
25713299	0	p120-catenin	8,20	Wnt11	115,120	p120-catenin	Wnt11	12388(Tax:10090)	22411(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|expression expression|amod|END_ENTITY	Nuclear p120-catenin regulates the anoikis resistance of mouse lobular breast cancer cells through Kaiso-dependent Wnt11 expression .
18343367	0	p120-catenin	80,92	desmoglein_3	113,125	p120-catenin	desmoglein 3	1500	1830	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
18343367	0	p120-catenin	80,92	desmoglein_3	24,36	p120-catenin	desmoglein 3	1500	1830	Gene	Gene	site|amod|START_ENTITY identification|nmod|site partner|dep|identification partner|amod|END_ENTITY	P120-catenin is a novel desmoglein_3 interacting partner : identification of the p120-catenin association site of desmoglein_3 .
15805267	0	p120E4F	83,90	cyclin_A2	30,39	p120E4F	cyclin A2	1877	890	Gene	Gene	enhanced|nmod|START_ENTITY Transcriptional|nmod|enhanced Transcriptional|dobj|regulation regulation|nmod|END_ENTITY	Transcriptional regulation of cyclin_A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin_A2 promoter .
15805267	0	p120E4F	83,90	cyclin_A2	98,107	p120E4F	cyclin A2	1877	890	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Transcriptional regulation of cyclin_A2 by RASSF1A through the enhanced binding of p120E4F to the cyclin_A2 promoter .
9743338	0	p120GAP	23,30	CD4	34,37	p120GAP	CD4	5921	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Sam68 association with p120GAP in CD4 + T cells is dependent on CD4 molecule expression .
9743338	0	p120GAP	23,30	CD4	63,66	p120GAP	CD4	5921	12504(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY dependent|nsubj|association dependent|nmod|expression expression|compound|END_ENTITY	Sam68 association with p120GAP in CD4 + T cells is dependent on CD4 molecule expression .
9743338	0	p120GAP	23,30	Sam68	0,5	p120GAP	Sam68	5921	20218(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Sam68 association with p120GAP in CD4 + T cells is dependent on CD4 molecule expression .
19151751	0	p120Ras-GAP	0,11	DLC1	22,26	p120Ras-GAP	DLC1	5921	10395	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|protein protein|compound|END_ENTITY	p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities .
19151751	0	p120Ras-GAP	0,11	Rho-GAP	27,34	p120Ras-GAP	Rho-GAP	5921	392	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|protein protein|compound|END_ENTITY	p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities .
7733887	0	p120_GAP	91,99	CaLB	71,75	p120 GAP	CaLB	5921	793	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Mutation-deletion analysis of a Ca -LRB- 2 + -RRB- - dependent phospholipid binding -LRB- CaLB -RRB- domain within p120_GAP , a GTPase-activating protein for p21_ras .
23423910	0	p120_catenin	135,147	E-cadherin	95,105	p120 catenin	E-cadherin	12388(Tax:10090)	12550(Tax:10090)	Gene	Gene	manner|nmod|START_ENTITY END_ENTITY|nmod|manner	Delta-catenin promotes the proliferation and invasion of colorectal_cancer cells by binding to E-cadherin in a competitive manner with p120_catenin .
24979278	0	p120_catenin	49,61	MUC1	0,4	p120 catenin	MUC1	1500	4582	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MUC1 regulates cyclin_D1 gene expression through p120_catenin and b-catenin .
10980705	0	p120_catenin	22,34	RhoA	14,18	p120 catenin	RhoA	1500	387	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of RhoA by p120_catenin .
17576929	0	p120_catenin	0,12	cortactin	84,93	p120 catenin	cortactin	1500	2017	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p120_catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin .
24979278	0	p120_catenin	49,61	cyclin_D1	15,24	p120 catenin	cyclin D1	1500	595	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	MUC1 regulates cyclin_D1 gene expression through p120_catenin and b-catenin .
23139153	0	p120_catenin	90,102	miR-197	0,7	p120 catenin	miR-197	1500	406974	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	miR-197 induces epithelial-mesenchymal transition in pancreatic_cancer cells by targeting p120_catenin .
9653641	0	p120ctn	31,38	CTNND1	53,59	p120ctn	CTNND1	1500	1500	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning of the human p120ctn catenin gene -LRB- CTNND1 -RRB- : expression of multiple alternatively spliced isoforms .
23481397	0	p120ctn	66,73	N-cadherin	0,10	p120ctn	N-cadherin	1500	1000	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	N-cadherin regulates spatially polarized signals through distinct p120ctn and b-catenin-dependent signalling pathways .
12135916	0	p120ctn	20,27	Rho1	0,4	p120ctn	Rho1	3355143(Tax:7227)	36775(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rho1 interacts with p120ctn and alpha-catenin , and regulates cadherin-based adherens junction components in Drosophila .
16207756	0	p120ctn	62,69	Rho1	0,4	p120ctn	Rho1	3355143(Tax:7227)	36775(Tax:7227)	Gene	Gene	junctions|nmod|START_ENTITY regulates|ccomp|junctions regulates|nsubj|END_ENTITY	Rho1 regulates Drosophila adherens junctions independently of p120ctn .
10480866	0	p125	66,70	DNA_polymerase_delta	102,122	p125	DNA polymerase delta	11196	5424	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Direct interaction of proliferating_cell_nuclear_antigen with the p125 catalytic subunit of mammalian DNA_polymerase_delta .
27022290	0	p125	31,35	p53	0,3	p125	p53	11196	7157	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast_cancer .
10457217	0	p125FAK	90,97	MRL/MP-lpr/lpr	113,127	p125FAK	MRL/MP-lpr/lpr	14083(Tax:10090)	14102(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Glomerular overexpression and increased tyrosine phosphorylation of focal adhesion kinase p125FAK in lupus-prone MRL/MP-lpr/lpr mice .
9064347	0	p125FAK	60,67	RANTES	0,6	p125FAK	RANTES	14083(Tax:10090)	20304(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells .
11496289	0	p125FAK	45,52	focal_adhesion_kinase	22,43	p125FAK	focal adhesion kinase	14083(Tax:10090)	5747	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the focal_adhesion_kinase -LRB- p125FAK -RRB- in the vascular smooth muscle cells of intimal_hyperplasia .
7796399	0	p125FAK	45,52	focal_adhesion_kinase	22,43	p125FAK	focal adhesion kinase	5747	5747	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of the focal_adhesion_kinase -LRB- p125FAK -RRB- in invasive human tumors .
9748234	0	p130	18,22	Cas	23,26	p130	Cas	9221	9564	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Direct binding of p130 -LRB- Cas -RRB- to the guanine_nucleotide exchange factor C3G .
8183562	0	p130	117,121	Crk	102,105	p130	Crk	70769(Tax:10090)	12928(Tax:10090)	Gene	Gene	associated|dobj|START_ENTITY END_ENTITY|acl|associated	The C-terminal SH3 domain of the mouse c-Crk protein negatively regulates tyrosine-phosphorylation of Crk associated p130 in rat_3Y1 cells .
10208422	0	p130	118,122	E2F-4	98,103	p130	E2F-4	9221	1874	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4 / pRB and E2F-4 / p130 complexes .
12006580	0	p130	41,45	E2F-4	79,84	p130	E2F-4	5934	1874	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	Distinct phosphorylation events regulate p130 - and p107-mediated repression of E2F-4 .
8657117	0	p130	20,24	E2F-4	0,5	p130	E2F-4	5934	1874	Gene	Gene	switches|nmod|START_ENTITY switches|nsubj|END_ENTITY	E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry .
8887669	0	p130	18,22	PTP-PEST	90,98	p130	PTP-PEST	9221	5782	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|substrate substrate|nmod|END_ENTITY	Identification of p130 -LRB- cas -RRB- as a substrate for the cytosolic protein_tyrosine_phosphatase PTP-PEST .
10760507	0	p130	78,82	RB2	73,76	p130	RB2	19651(Tax:10090)	19651(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A CDE/CHR-like element mediates repression of transcription of the mouse RB2 -LRB- p130 -RRB- gene .
12717421	0	p130	21,25	SKP2	0,4	p130	SKP2	5934	6502	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells .
10969803	0	p130	69,73	histone_deacetylase_1	42,63	p130	histone deacetylase 1	70769(Tax:10090)	433759(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY recruits|nmod|complex recruits|dobj|END_ENTITY	Transforming_growth_factor-beta1 recruits histone_deacetylase_1 to a p130 repressor complex in transgenic_mice in vivo .
10906146	0	p130	78,82	pRB	94,97	p130	pRB	5934	5925	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB -LRB- - -RRB- , p16INK4A -LRB- + -RRB- tumor cells .
8810278	0	p130CAS	0,7	CRKL	59,63	p130CAS	CRKL	9564	1399	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|complex complex|nmod|END_ENTITY	p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene .
15728191	0	p130Cas	33,40	Ajuba	16,21	p130Cas	Ajuba	12927(Tax:10090)	16475(Tax:10090)	Gene	Gene	localization|amod|START_ENTITY influences|dobj|localization influences|nsubj|END_ENTITY	The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration .
27051236	0	p130Cas	25,32	Angiotensin_II	0,14	p130Cas	Angiotensin II	12927(Tax:10090)	11606(Tax:10090)	Gene	Gene	Modulates|dobj|START_ENTITY Modulates|nsubj|END_ENTITY	Angiotensin_II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase .
10639512	0	p130Cas	48,55	BCAR1	0,5	p130Cas	BCAR1	9564	9564	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	BCAR1 , a human homologue of the adapter protein p130Cas , and antiestrogen resistance in breast_cancer cells .
16040804	0	p130Cas	58,65	GD3	12,15	p130Cas	GD3	9564	117189	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant_melanoma cells .
27068854	0	p130Cas	104,111	GD3	167,170	p130Cas	GD3	9564	117189	Gene	Gene	START_ENTITY|acl|activated activated|nmod|expression expression|nmod|END_ENTITY	A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3 .
10320483	0	p130Cas	96,103	LAR	35,38	p130Cas	LAR	9564	5792	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Transmembrane_tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas .
24010014	0	p130Cas	78,85	Lmo7	40,44	p130Cas	Lmo7	9564	4008	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The emerin-binding transcription factor Lmo7 is regulated by association with p130Cas at focal adhesions .
8621540	0	p130Cas	39,46	Src	73,76	p130Cas	Crk	12927(Tax:10090)	12928(Tax:10090)	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase .
15020686	0	p130Cas	0,7	estrogen_receptor_alpha	23,46	p130Cas	estrogen receptor alpha	9564	2099	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	p130Cas interacts with estrogen_receptor_alpha and modulates non-genomic estrogen signaling in breast_cancer cells .
9242628	0	p130Cas	73,80	related_adhesion_focal_tyrosine_kinase	4,42	p130Cas	related adhesion focal tyrosine kinase	9564	2185	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The related_adhesion_focal_tyrosine_kinase differentially phosphorylates p130Cas and the Cas-like protein , p105HEF1 .
9285683	0	p130cas	47,54	PTP-PEST	15,23	p130cas	PTP-PEST	9564	5782	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Association of PTP-PEST with the SH3 domain of p130cas ; a novel mechanism of protein tyrosine phosphatase substrate recognition .
8995252	0	p130cas	127,134	related_adhesion_focal_tyrosine_kinase	4,42	p130cas	related adhesion focal tyrosine kinase	9564	2185	Gene	Gene	tyrosine-phosphorylated|nmod|START_ENTITY tyrosine-phosphorylated|nsubjpass|END_ENTITY	The related_adhesion_focal_tyrosine_kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas .
11883935	0	p14	57,60	E2F1	69,73	p14	E2F1	1029	1869	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of the human tumor suppressor p14 -LRB- ARF -RRB- by E2F1 , E2F2 , E2F3 , and Sp1-like factors .
24169260	0	p14	35,38	EGFR	58,62	p14	EGFR	11102	1956	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Mutation of TP53 and alteration of p14 -LRB- arf -RRB- expression in EGFR - and KRAS-mutated lung_adenocarcinomas .
15312681	0	p14	20,23	INK4A	33,38	p14	INK4A	1029	1029	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|expression expression|compound|END_ENTITY	Correlation between p14 -LRB- ARF -RRB- / p16 -LRB- INK4A -RRB- expression and HPV_infection_in_uterine_cervical_cancer .
23516888	0	p14	39,42	P53	15,18	p14	P53	11102	7157	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|c-Myc c-Myc|compound|END_ENTITY	-LSB- Expression of P53 , NPM1 , Kras , c-Myc , p14 -LRB- ARF -RRB- genes in blood cells of cancer patients before and after radiation therapy -RSB- .
19181545	0	p14	136,139	RASSF1A	141,148	p14	RASSF1A	1029	11186	Gene	Gene	genes|dep|START_ENTITY genes|nummod|END_ENTITY	Increase sensitivity in detecting superficial , low grade bladder_cancer by combination analysis of hypermethylation of E-cadherin , p16 , p14 , RASSF1A genes in urine .
22621932	0	p14	85,88	Transforming_growth_factor_b1	0,29	p14	Transforming growth factor b1	11102	7040	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Transforming_growth_factor_b1 -LRB- TGF-b1 -RRB- suppresses growth of B-cell_lymphoma cells by p14 -LRB- ARF -RRB- - dependent regulation of mutant p53 .
23516888	0	p14	39,42	c-Myc	32,37	p14	c-Myc	11102	4609	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of P53 , NPM1 , Kras , c-Myc , p14 -LRB- ARF -RRB- genes in blood cells of cancer patients before and after radiation therapy -RSB- .
23158280	0	p14	15,18	c-myc	72,77	p14	c-myc	11102	4609	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression apoptosis|nsubj|Regulation apoptosis|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Regulation of p14 -LRB- ARF -RRB- expression and induction of cell apoptosis with c-myc in a p53-independent pathway -RSB- .
10401580	0	p14	24,27	cofactor_A	29,39	p14	cofactor A	11102	6902	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulated expression of p14 -LRB- cofactor_A -RRB- during spermatogenesis .
17395400	0	p14	59,62	mdm2	74,78	p14	mdm2	1029	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
11314047	0	p14	64,67	p16	110,113	p14	p16	1029	1029	Gene	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Quantitative real-time PCR does not show selective targeting of p14 -LRB- ARF -RRB- but concomitant inactivation of both p16 -LRB- INK4A -RRB- and p14 -LRB- ARF -RRB- in 105 human primary_gliomas .
16115229	0	p14	90,93	p16	75,78	p14	p16	1029	1029	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
16258956	0	p14	111,114	p16	87,90	p14	p16	1029	1029	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|appos|-RSB-	Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors -LSB- p16 -LRB- INK4a -RRB- , p15 -LRB- INK4b -RRB- , p14 -LRB- ARF -RRB- -RSB- in mantle_cell_lymphoma .
17395400	0	p14	59,62	p16	64,67	p14	p16	1029	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
26255234	0	p14	8,11	p16	17,20	p14	p16	1029	1029	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	CDKN2A -LRB- p14 -LRB- ARF -RRB- / p16 -LRB- INK4a -RRB- -RRB- and ATM promoter methylation in patients with impalpable breast_lesions .
16115229	0	p14	90,93	p21	80,83	p14	p21	1029	644914	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p14	59,62	p21	49,52	p14	p21	1029	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
16115229	0	p14	90,93	p27	85,88	p14	p27	1029	10671	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p14	59,62	p27	54,57	p14	p27	1029	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
10797439	0	p14	48,51	p53	32,35	p14	p53	1029	7157	Gene	Gene	/|dobj|START_ENTITY /|nsubj|Investigation Investigation|nmod|INK4A INK4A|dep|END_ENTITY	Investigation of germline PTEN , p53 , p16 -LRB- INK4A -RRB- / p14 -LRB- ARF -RRB- , and CDK4 alterations in familial_glioma .
10801444	0	p14	56,59	p53	68,71	p14	p53	11102	7157	Gene	Gene	domains|nmod|START_ENTITY domains|nmod|stabilization stabilization|compound|END_ENTITY	Contribution of two independent MDM2-binding domains in p14 -LRB- ARF -RRB- to p53 stabilization .
11507034	0	p14	0,3	p53	89,92	p14	p53	1029	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	p14 -LRB- ARF -RRB- modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53 .
12082630	0	p14	38,41	p53	55,58	p14	p53	1029	7157	Gene	Gene	overexpression|nmod|START_ENTITY induces|nsubj|overexpression induces|dobj|apoptosis apoptosis|compound|END_ENTITY	Adenovirus-mediated overexpression of p14 -LRB- ARF -RRB- induces p53 and Bax-independent apoptosis .
12082636	0	p14	6,9	p53	69,72	p14	p53	1029	7157	Gene	Gene	START_ENTITY|dep|cell cell|acl:relcl|depends depends|nmod|END_ENTITY	Human p14 -LRB- ARF -RRB- - mediated cell cycle arrest strictly depends on intact p53 signaling pathways .
15073599	0	p14	15,18	p53	71,74	p14	p53	11102	7157	Gene	Gene	gene|amod|START_ENTITY Methylation|nmod|gene Methylation|nmod|expression expression|compound|END_ENTITY	Methylation of p14 -LRB- ARF -RRB- gene in meningiomas and its correlation to the p53 expression and mutation .
16162359	0	p14	112,115	p53	4,7	p14	p53	11102	7157	Gene	Gene	expression|amod|START_ENTITY association|nmod|expression expression|dep|association expression|compound|END_ENTITY	Low p53 expression of acute_myelocytic_leukemia cells with t -LRB- 8 ; 21 -RRB- chromosome_abnormality : association with low p14 -LRB- ARF -RRB- expression .
17395400	0	p14	59,62	p53	69,72	p14	p53	1029	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
22354970	0	p14	0,3	p53	30,33	p14	p53	11102	7157	Gene	Gene	START_ENTITY|dep|apoptosis apoptosis|nmod|END_ENTITY	p14 -LRB- ARF -RRB- - induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins .
22621932	0	p14	85,88	p53	125,128	p14	p53	11102	7157	Gene	Gene	START_ENTITY|dep|regulation regulation|nmod|END_ENTITY	Transforming_growth_factor_b1 -LRB- TGF-b1 -RRB- suppresses growth of B-cell_lymphoma cells by p14 -LRB- ARF -RRB- - dependent regulation of mutant p53 .
9724636	0	p14	53,56	p53	111,114	p14	p53	1029	7157	Gene	Gene	product|appos|START_ENTITY participates|nsubj|product participates|nmod|loop loop|nmod|END_ENTITY	The alternative product from the human CDKN2A locus , p14 -LRB- ARF -RRB- , participates in a regulatory feedback loop with p53 and MDM2 .
20081198	0	p140	83,87	BRCA1	27,32	p140	BRCA1	80725	672	Gene	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	Structure of the DNA-bound BRCA1 C-terminal region from human replication factor C p140 and model of the protein-DNA complex .
10578054	0	p144	49,53	CA150	70,75	p144	CA150	56070(Tax:10090)	56070(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Molecular cloning and splicing isoforms of mouse p144 , a homologue of CA150 .
18703154	0	p14ARF	15,21	Brca1	27,32	p14ARF	Brca1	1029	672	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of p14ARF with Brca1 in cancer cell lines and primary breast_cancer .
22860085	0	p14ARF	33,39	CDK5RAP3	0,8	p14ARF	CDK5RAP3	1029	80279	Gene	Gene	repressor|nmod|START_ENTITY repressor|nsubj|END_ENTITY	CDK5RAP3 is a novel repressor of p14ARF in hepatocellular_carcinoma cells .
17970080	0	p14ARF	74,80	CDKN2A	66,72	p14ARF	CDKN2A	1029	1029	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Promoter hypermethylation and quantitative expression analysis of CDKN2A -LRB- p14ARF and p16INK4a -RRB- gene in esophageal_squamous_cell_carcinoma .
17017004	0	p14ARF	20,26	DNMT3B	63,69	p14ARF	DNMT3B	1029	1789	Gene	Gene	expression|nmod|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|compound|END_ENTITY	Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal_squamous_cell_carcinomas .
19115249	0	p14ARF	41,47	E2F1	27,31	p14ARF	E2F1	1029	1869	Gene	Gene	activation|amod|START_ENTITY promotes|dobj|activation promotes|nsubj|END_ENTITY	8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites .
12085228	0	p14ARF	43,49	MDM2	73,77	p14ARF	MDM2	1029	4193	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2 .
16410719	0	p14ARF	0,6	Myc	31,34	p14ARF	Myc	1029	4609	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	p14ARF directly interacts with Myc through the Myc BoxII domain .
16410719	0	p14ARF	0,6	Myc	47,50	p14ARF	Myc	1029	4609	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|domain domain|compound|END_ENTITY	p14ARF directly interacts with Myc through the Myc BoxII domain .
17289033	0	p14ARF	0,6	N-Myc	22,27	p14ARF	N-Myc	1029	4613	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	p14ARF interacts with N-Myc and inhibits its transcriptional activity .
17334400	0	p14ARF	40,46	TBP-1	0,5	p14ARF	TBP-1	1029	5702	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation .
12000749	0	p14ARF	83,89	TBX2	21,25	p14ARF	TBX2	1029	6909	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator .
22860097	0	p14ARF	0,6	cyclin_D1	50,59	p14ARF	cyclin D1	1029	595	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	p14ARF post-transcriptional regulation of nuclear cyclin_D1 in MCF-7 breast_cancer cells : discrimination between a good and bad prognosis ?
15205349	0	p14ARF	0,6	dihydrofolate_reductase	28,51	p14ARF	dihydrofolate reductase	1029	1719	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	p14ARF expression increases dihydrofolate_reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53 .
12357355	0	p14ARF	42,48	p16ink4a	32,40	p14ARF	p16ink4a	1029	1029	Gene	Gene	genes|amod|START_ENTITY END_ENTITY|appos|genes	Deletion of the Ink4-locus -LRB- the p16ink4a , p14ARF and p15ink4b genes -RRB- predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92 .
11526482	0	p14ARF	21,27	p53	59,62	p14ARF	p53	1029	7157	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo .
15367673	0	p14ARF	46,52	p63	14,17	p14ARF	p53	1029	7157	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of p63 transcriptional activity by p14ARF : functional and physical link between human ARF_tumor suppressor and a member of the p53 family .
17575133	0	p14arf	52,58	TP53	24,28	p14arf	TP53	1029	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Patterns of EGFR , HER2 , TP53 , and KRAS mutations of p14arf expression in non-small_cell_lung_cancers in relation to smoking history .
21151178	0	p15	83,86	ANRIL	20,25	p15	ANRIL	1030	100048912	Gene	Gene	silencing|nmod|START_ENTITY gene|dep|silencing required|nmod|gene required|nsubjpass|END_ENTITY	Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 -LRB- INK4B -RRB- tumor suppressor gene .
24747824	0	p15	15,18	ANRIL	0,5	p15	ANRIL	1030	100048912	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	ANRIL inhibits p15 -LRB- INK4b -RRB- through the TGFb1 signaling pathway in human esophageal_squamous_cell_carcinoma .
10541865	0	p15	73,76	CDKN2B	65,71	p15	CDKN2B	1030	1030	Gene	Gene	CDKN2A|appos|START_ENTITY CDKN2A|dep|END_ENTITY	Functional evidence for a role of combined CDKN2A -LRB- p16-p14 -LRB- ARF -RRB- -RRB- / CDKN2B -LRB- p15 -RRB- gene inactivation in malignant_gliomas .
19014416	0	p15	137,140	CDKN2B	129,135	p15	CDKN2B	1030	1030	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Rapid analysis of heterogeneously methylated DNA using digital methylation-sensitive high resolution melting : application to the CDKN2B -LRB- p15 -RRB- gene .
15473298	0	p15	39,42	EGFR	77,81	p15	EGFR	1030	1956	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	-LSB- Association of homozygous deletion of p15 and p16 gene and amplification of EGFR gene in laryngeal_squamous_cell_carcinoma -RSB- .
16298343	0	p15	32,35	Histone_deacetylase_3	0,21	p15	Histone deacetylase 3	1030	8841	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Histone_deacetylase_3 represses p15 -LRB- INK4b -RRB- and p21 -LRB- WAF1/cip1 -RRB- transcription by interacting with Sp1 .
10090949	0	p15	30,33	INK4B	34,39	p15	INK4B	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Acquisition of p16 -LRB- INK4A -RRB- and p15 -LRB- INK4B -RRB- gene abnormalities between initial diagnosis and relapse in children with acute_lymphoblastic_leukemia .
10574984	0	p15	41,44	INK4B	45,50	p15	INK4B	1030	1030	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Transforming_growth_factor-beta-mediated p15 -LRB- INK4B -RRB- induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines .
10812241	0	p15	48,51	INK4B	52,57	p15	INK4B	1030	1030	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of cyclin-dependent kinase inhibitor p15 -LRB- INK4B -RRB- during normal and leukemic myeloid differentiation .
11167795	0	p15	19,22	INK4B	23,28	p15	INK4B	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylation of the p15 -LRB- INK4B -RRB- gene in myelodysplastic_syndrome : it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation .
12150726	0	p15	24,27	INK4B	28,33	p15	INK4B	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hypermethylation of the p15 -LRB- INK4B -RRB- gene in acute_leukemia and myelodysplastic_syndromes .
12485524	0	p15	22,25	INK4B	26,31	p15	INK4B	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The re-expression of p15 -LRB- INK4B -RRB- gene in leukemia cells induced by in vitro DNA methyltransferase and histone deacetylase inhibition -RSB- .
12578663	0	p15	25,28	INK4B	29,34	p15	INK4B	1030	1030	Gene	Gene	Gene|compound|START_ENTITY Gene|appos|END_ENTITY	-LSB- Study on Methylation of p15 -LRB- INK4B -RRB- Gene in Acute Myeloid_Leukemia and Chronic_Myeloid_Leukemia -RSB- In order to explore the role of p15 -LRB- INK4B -RRB- gene with highly methylated CpG island in the pathogenesis of leukemia , the expression levels of p15 -LRB- INK4B -RRB- gene was detected in patients with AML and CML .
21544337	0	p15	31,34	INK4B	35,40	p15	INK4B	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of RB , p16/CDKN2 and p15 -LRB- INK4B -RRB- gene alterations with immunohistochemical studies in human prostate_carcinomas .
8847892	0	p15	103,106	INK4B	107,112	p15	INK4B	1030	1030	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	A novel pre-B acute_lymphoblastic_leukemia cell line with chromosomal translocation between p16 -LRB- INK4A -RRB- / p15 -LRB- INK4B -RRB- tumor suppressor and immunoglobulin heavy chain genes : TGFbeta/IL -7 inhibitory signaling mechanism .
16258956	0	p15	99,102	INK4a	91,96	p15	INK4a	1030	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors -LSB- p16 -LRB- INK4a -RRB- , p15 -LRB- INK4b -RRB- , p14 -LRB- ARF -RRB- -RSB- in mantle_cell_lymphoma .
11418489	0	p15	15,18	INK4b	19,24	p15	INK4b	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p16 -LRB- INK4a -RRB- and p15 -LRB- INK4b -RRB- gene methylations in plasma cells from monoclonal_gammopathy of undetermined significance .
11445839	0	p15	35,38	INK4b	39,44	p15	INK4b	1030	1030	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Hypermethylation of p16 -LRB- INK4a -RRB- and p15 -LRB- INK4b -RRB- genes in non-small cell lung_cancer .
12513775	0	p15	16,19	INK4b	20,25	p15	INK4b	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Abnormality of p15 -LRB- INK4b -RRB- gene and myelodysplastic_syndrome -RSB- .
12750706	0	p15	111,114	INK4b	115,120	p15	INK4b	1030	1030	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hypermethylation of GpG islands in the promoter region of p15 -LRB- INK4b -RRB- in acute_promyelocytic_leukemia represses p15 -LRB- INK4b -RRB- expression and correlates with poor prognosis .
15474025	0	p15	66,69	INK4b	70,75	p15	INK4b	1030	1030	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Indole-3-carbinol activates the cyclin-dependent kinase inhibitor p15 -LRB- INK4b -RRB- gene .
17316622	0	p15	59,62	INK4b	63,68	p15	INK4b	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Oct-1 is involved in the transcriptional repression of the p15 -LRB- INK4b -RRB- gene .
22783444	0	p15	15,18	INK4b	19,24	p15	INK4b	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p16 -LRB- INK4a -RRB- and p15 -LRB- INK4b -RRB- gene promoter methylation in cervical_cancer patients .
9033652	0	p15	57,60	INK4b	61,66	p15	INK4b	1030	1030	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Multiple types of aberrations in the p16 -LRB- INK4a -RRB- and the p15 -LRB- INK4b -RRB- genes in 30 esophageal squamous-cell-carcinoma cell lines .
9531610	0	p15	19,22	INK4b	23,28	p15	INK4b	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylation of the p15 -LRB- INK4b -RRB- gene in myelodysplastic_syndromes is frequent and acquired during disease progression .
11897669	8	p15	1161,1164	Ink4B	1165,1170	p15	Ink4B	1030	1030	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	p15 -LRB- Ink4B -RRB- mRNA is also up-regulated with TGF_beta 1 treatment in OC2-9 , whereas the p15 -LRB- Ink4B -RRB- gene has been deleted in OC1 , CaOV3 , and SkOV3 cells .
17900658	0	p15	55,58	Rb1	36,39	p15	Rb1	1030	5925	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular_lymphoma .
11435325	0	p15	14,17	ink4b	18,23	p15	ink4b	1030	1030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of p15 -LRB- ink4b -RRB- gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors .
10641574	0	p15	87,90	p16	98,101	p15	p16	1030	1029	Gene	Gene	START_ENTITY|acl|/ /|dobj|END_ENTITY	The incidence of chromosome 9p21 abnormalities and deletions of tumor suppressor genes p15 -LRB- INK4b -RRB- / p16 -LRB- INK4a -RRB- / p14 -LRB- ARF -RRB- in patients with acute_lymphoblastic_leukemia .
12894891	0	p15	37,40	p16	33,36	p15	p16	1030	1029	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Deletions and point mutations of p16 , p15 gene in primary_tumors and tumor cell lines .
15469082	0	p15	69,72	p16	74,77	p15	p16	1030	1029	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	-LSB- Expression of survivin gene and its relationship with expression of p15 , p16 proteins in laryngeal_squamous_cell_carcinomas -RSB- .
15892297	0	p15	4,7	p16	15,18	p15	p16	1030	1029	Gene	Gene	INK4b|amod|START_ENTITY INK4b|dep|END_ENTITY	The p15 -LRB- INK4b -RRB- / p16 -LRB- INK4a -RRB- / RB1 pathway is frequently deregulated in human pituitary_adenomas .
19837270	0	p15	53,56	p16	31,34	p15	p16	1030	1029	Gene	Gene	CDKN2A|appos|START_ENTITY CDKN2A|dep|END_ENTITY	Homozygous deletion of CDKN2A -LRB- p16 , p14 -RRB- and CDKN2B -LRB- p15 -RRB- genes is a poor prognostic factor in adult but not in childhood B-lineage acute_lymphoblastic_leukemia : a comparative deletion and hypermethylation study .
8847892	0	p15	103,106	p16	92,95	p15	p16	1030	1029	Gene	Gene	suppressor|amod|START_ENTITY END_ENTITY|dep|suppressor	A novel pre-B acute_lymphoblastic_leukemia cell line with chromosomal translocation between p16 -LRB- INK4A -RRB- / p15 -LRB- INK4B -RRB- tumor suppressor and immunoglobulin heavy chain genes : TGFbeta/IL -7 inhibitory signaling mechanism .
9164185	0	p15	13,16	p16	24,27	p15	p16	1030	1029	Gene	Gene	Deletions|nmod|START_ENTITY and/or|nsubj|Deletions and/or|dobj|genes genes|amod|END_ENTITY	Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult_T-cell_leukemia .
9624535	0	p15	34,37	p16	22,25	p15	p16	1030	1029	Gene	Gene	CDKN2B|appos|START_ENTITY alterations|nsubj|CDKN2B Association|parataxis|alterations Association|nmod|CDKN2A CDKN2A|appos|END_ENTITY	Association of CDKN2A -LRB- p16 -RRB- / CDKN2B -LRB- p15 -RRB- alterations and homozygous chromosome arm 9p deletions in human lung_carcinoma .
24906008	0	p150	38,42	ADAR1	31,36	p150	ADAR1	10036	103	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	Reovirus-mediated induction of ADAR1 -LRB- p150 -RRB- minimally alters RNA editing patterns in discrete brain regions .
24726838	0	p150	58,62	Akt	31,34	p150	Akt	10036	207	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Microtubule dynamics regulates Akt signaling via dynactin p150 .
19919826	0	p150	4,8	CAF-1	20,25	p150	CAF-1	10036	10036	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci .
21570500	0	p150	4,8	Caf-1	42,47	p150	Caf-1	13191(Tax:10090)	27221(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1 .
2428876	0	p150	42,46	Mac-1	28,33	p150	Mac-1	10036	3684	Gene	Gene	family|amod|START_ENTITY family|compound|END_ENTITY	Regulated expression of the Mac-1 , LFA-1 , p150 ,95 glycoprotein family during leukocyte differentiation .
2521491	1	p150	170,174	Mac-1	156,161	p150	Mac-1	10036	3684	Gene	Gene	family|amod|START_ENTITY family|compound|END_ENTITY	Stimulation by chemotactic peptides and lipid mediators and dependence upon the Mac-1 , LFA-1 , p150 ,95 glycoprotein family .
19935774	0	p150	52,56	SNX6	23,27	p150	SNX6	10036	58533	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The retromer component SNX6 interacts with dynactin p150 -LRB- Glued -RRB- and mediates endosome-to-TGN transport .
23029531	0	p150	42,46	c-MYC	81,86	p150	c-MYC	10036	4609	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC .
25057015	0	p150	26,30	chromatin_assembly_factor-1	48,75	p150	chromatin assembly factor-1	10036	10036	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	A separable domain of the p150 subunit of human chromatin_assembly_factor-1 promotes protein and chromosome associations with nucleoli .
16826239	0	p150	65,69	chromatin_assembly_factor_1	81,108	p150	chromatin assembly factor 1	10036	10036	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin_assembly_factor_1 with proliferating_cell_nuclear_antigen .
25774020	0	p150	54,58	glued	59,64	p150	glued	10036	10036	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Cell Cycle-Dependent Localization of Dynactin Subunit p150 -LRB- glued -RRB- at Centrosome .
15082782	0	p150	0,4	p21	45,48	p150	p21	10036	1026	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	p150 -LRB- Sal2 -RRB- is a p53-independent regulator of p21 -LRB- WAF1/CIP -RRB- .
21791360	0	p150	102,106	p21	41,44	p150	p21	10036	1026	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|transcription transcription|amod|END_ENTITY	Human_papillomavirus_type_16 E6 inhibits p21 -LRB- WAF1 -RRB- transcription independently of p53 by inactivating p150 -LRB- Sal2 -RRB- .
8744947	0	p150Glued	0,9	dynactin	38,46	p150Glued	dynactin	39536(Tax:7227)	39536(Tax:7227)	Gene	Gene	START_ENTITY|appos|subunit subunit|nmod|complex complex|compound|END_ENTITY	p150Glued , the largest subunit of the dynactin complex , is nonessential in Neurospora but required for nuclear distribution .
15093610	0	p15INK4B	105,113	Activin	0,7	p15INK4B	Activin	1030	83729	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	Activin induces hepatocyte cell growth arrest through induction of the cyclin-dependent kinase inhibitor p15INK4B and Sp1 .
19164764	0	p15INK4B	32,40	Gfi-1	0,5	p15INK4B	Gfi-1	1030	2672	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1 .
9001419	0	p15INK4B	65,73	p18INK4C	75,83	p15INK4B	p18INK4C	1030	1031	Gene	Gene	p16INK4A|appos|START_ENTITY p16INK4A|appos|END_ENTITY	Expression and regulation of G1 cell-cycle inhibitors -LRB- p16INK4A , p15INK4B , p18INK4C , p19INK4D -RRB- in human acute_myeloid_leukemia and normal myeloid cells .
9001419	0	p15INK4B	65,73	p19INK4D	85,93	p15INK4B	p19INK4D	1030	1032	Gene	Gene	p16INK4A|appos|START_ENTITY p16INK4A|appos|END_ENTITY	Expression and regulation of G1 cell-cycle inhibitors -LRB- p16INK4A , p15INK4B , p18INK4C , p19INK4D -RRB- in human acute_myeloid_leukemia and normal myeloid cells .
11283613	0	p15INK4b	14,22	Myc	37,40	p15INK4b	Myc	12579(Tax:10090)	17869(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Repression of p15INK4b expression by Myc through association with Miz-1 .
23949224	0	p16	27,30	AP4	0,3	p16	AP4	12578(Tax:10090)	83383(Tax:10090)	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation .
26422859	0	p16	54,57	BCL-xL	86,92	p16	BCL-xL	1029	598	Gene	Gene	START_ENTITY|appos|Bax Bax|nummod|END_ENTITY	Determination-of apoptosis and cell cycle modulators -LRB- p16 , p21 , p27 , p53 , BCL-2 , Bax , BCL-xL , and cyclin_D1 -RRB- in thyroid_follicular_carcinoma , follicular_adenoma , and adenomatous nodules via a tissue microarray method .
26398519	0	p16	90,93	BUB3	84,88	p16	BUB3	1029	9184	Gene	Gene	Ki67|dep|START_ENTITY Ki67|compound|END_ENTITY	In situ carcinoma developed over_oral_lichen_planus : a case report with analysis of BUB3 , p16 , p53 , Ki67 and SOX4 expression .
26960457	0	p16	19,22	Bcl-2	30,35	p16	Bcl-2	1029	596	Gene	Gene	Ki-67|appos|START_ENTITY Ki-67|appos|END_ENTITY	The role of Ki-67 , p16 , CD34 , Bcl-2 , cyclooxygenase-2 in the pathogenesis of proliferative_verrucous_leukoplakia .
25262972	0	p16	67,70	Bmi-1	0,5	p16	Bmi-1	1029	648	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Bmi-1 regulates the migration and invasion of glioma cells through p16 .
25832744	0	p16	27,30	Bmi-1	21,26	p16	Bmi-1	12578(Tax:10090)	12151(Tax:10090)	Gene	Gene	provokes|nsubj|START_ENTITY Dysregulation|parataxis|provokes Dysregulation|nmod|END_ENTITY	Dysregulation of the Bmi-1 / p16 -LRB- Ink4a -RRB- pathway provokes an aging-associated decline of submandibular gland function .
26960457	0	p16	19,22	CD34	24,28	p16	CD34	1029	947	Gene	Gene	Ki-67|appos|START_ENTITY Ki-67|appos|END_ENTITY	The role of Ki-67 , p16 , CD34 , Bcl-2 , cyclooxygenase-2 in the pathogenesis of proliferative_verrucous_leukoplakia .
10488417	0	p16	19,22	CDK4	24,28	p16	CDK4	1029	1019	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression -RSB-|advcl|-LSB- -RSB-|nsubj|END_ENTITY	-LSB- The expression of p16 , CDK4 and pRb in hepatocellular_carcinomas -RSB- .
12212108	0	p16	26,29	CDK4	44,48	p16	CDK4	1029	1019	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- The effects of exogenous p16 expression on CDK4 , Cyclin_D1 and pRb in nasopharyngeal_carcinoma cell lines -RSB- .
25109634	0	p16	54,57	CDK4	59,63	p16	CDK4	1029	1019	Gene	Gene	2|nummod|START_ENTITY 2|nummod|END_ENTITY	Alterations of cell cycle control proteins SHP __ -1 / 2 , p16 , CDK4 and cyclin_D1 in radioresistant nasopharyngeal_carcinoma cells .
8621248	0	p16	35,38	CDK4	40,44	p16	CDK4	1029	1019	Gene	Gene	p15|nummod|START_ENTITY p15|nummod|END_ENTITY	Infrequent alterations of the p15 , p16 , CDK4 and cyclin_D1 genes in non-astrocytic human brain_tumors .
10378889	0	p16	14,17	CDKN2	19,24	p16	CDKN2	1029	1029	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Alteration of p16 -LRB- CDKN2 -RRB- gene is associated with interleukin-2-induced tumor cell growth in adult_T-cell_leukemia .
17466040	0	p16	0,3	CDKN2	4,9	p16	CDKN2	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p16 -LRB- CDKN2 -RRB- gene polymorphism : association with histologic subtypes of epithelial_ovarian_cancer in China .
7668266	0	p16	120,123	CDKN2	125,130	p16	CDKN2	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosome 9p deletions in cutaneous_malignant_melanoma_tumors : the minimal deleted region involves markers outside the p16 -LRB- CDKN2 -RRB- gene .
7987388	0	p16	16,19	CDKN2	26,31	p16	CDKN2	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the p16 gene -LRB- CDKN2 -RRB- as a candidate for the chromosome 9p melanoma susceptibility locus .
8570179	0	p16	16,19	CDKN2	26,31	p16	CDKN2	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the p16 gene , CDKN2 , in 17 Australian melanoma kindreds .
8589032	0	p16	22,25	CDKN2	15,20	p16	CDKN2	1029	1029	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of CDKN2 -LRB- p16 -RRB- in non-small_cell_lung_cancer .
9309120	0	p16	74,77	CDKN2	78,83	p16	CDKN2	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequent allelic losses of 9p21 markers and low incidence of mutations at p16 -LRB- CDKN2 -RRB- gene in non-Hodgkin_lymphomas of B-cell lineage .
9815578	0	p16	30,33	CDKN2	23,28	p16	CDKN2	1029	1029	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Frequent alteration of CDKN2 -LRB- p16 -LRB- INK4A -RRB- / MTS1 -RRB- expression in human primary_prostate_carcinomas .
18804414	0	p16	0,3	CDKN2A	4,10	p16	CDKN2A	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p16 -LRB- CDKN2A -RRB- expression during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide .
20569442	0	p16	43,46	CDKN2A	24,30	p16	CDKN2A	1029	1029	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular_carcinoma .
22751687	0	p16	16,19	CDKN2A	20,26	p16	CDKN2A	1029	101089220	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The presence of p16 CDKN2A protein immunostaining within feline nasal_planum_squamous_cell_carcinomas is associated with an increased survival time and the presence of papillomaviral DNA .
24944814	0	p16	20,23	CDKN2A	24,30	p16	CDKN2A	1029	1029	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between p16 -LRB- CDKN2A -RRB- C540G polymorphism and tumor behavior in prolactinoma : A single-center study .
25921285	0	p16	8,11	CDKN2A	0,6	p16	CDKN2A	1029	1029	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	CDKN2A -LRB- p16 -RRB- mRNA decreased expression is a marker of poor prognosis in malignant high-grade glioma .
9041193	0	p16	33,36	CDKN2A	38,44	p16	CDKN2A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion map of chromosome 9 and p16 -LRB- CDKN2A -RRB- gene alterations in neuroblastoma .
9872329	0	p16	4,7	CDKN2A	9,15	p16	CDKN2A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The p16 -LRB- CDKN2A -RRB- gene is involved in the growth of neuroblastoma cells and its expression is associated with prognosis of neuroblastoma patients .
19148359	0	p16	6,9	COX-2	12,17	p16	COX-2	1029	4513	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- p53 , p16 E COX-2 expression in esophageal_squamous_cell_carcinoma and histopathological association -RSB- .
18787961	0	p16	50,53	CyclinD1	18,26	p16	CyclinD1	1029	595	Gene	Gene	correlate|amod|START_ENTITY END_ENTITY|nmod|correlate	Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node metastases in laryngeal_squamous_cell_carcinoma in Chinese patients .
10376532	0	p16	42,45	Cyclin_D1	0,9	p16	Cyclin D1	1029	595	Gene	Gene	inactivation|amod|START_ENTITY independent|nmod|inactivation independent|nsubj|amplification amplification|amod|END_ENTITY	Cyclin_D1 amplification is independent of p16 inactivation in head_and_neck_squamous_cell_carcinoma .
20948919	0	p16	23,26	Cyclin_D1	28,37	p16	Cyclin D1	1029	595	Gene	Gene	role|appos|START_ENTITY role|appos|proteins proteins|amod|END_ENTITY	Prognostic role of Rb , p16 , Cyclin_D1 proteins in soft tissue sarcomas .
22010578	0	p16	23,26	E2FBP1	0,6	p16	E2FBP1	1029	1820	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	E2FBP1 antagonizes the p16 -LRB- INK4A -RRB- - Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic_leukemia_protein stability .
21352589	0	p16	47,50	EGFR	24,28	p16	EGFR	1029	1956	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	The association between EGFR variant III , HPV , p16 , c-MET , EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous_cell_carcinoma of the head_and_neck .
16998811	0	p16	60,63	EZH2	49,53	p16	EZH2	1029	2146	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
23289480	0	p16	33,36	EZH2	0,4	p16	EZH2	1029	2146	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	EZH2 regulates the expression of p16 in the nasopharyngeal_cancer cells .
24612037	0	p16	139,142	EZH2	40,44	p16	EZH2	13088(Tax:10090)	14056(Tax:10090)	Gene	Gene	upregulation|nmod|START_ENTITY depletes|nmod|upregulation depletes|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of mixed lineage_leukemia fusion leukemia through upregulation of p16 .
26096306	0	p16	67,70	EZH2	0,4	p16	EZH2	1029	2146	Gene	Gene	loss|amod|START_ENTITY expression|dep|loss expression|nummod|END_ENTITY	EZH2 expression in gliomas : Correlation with CDKN2A gene deletion / p16 loss and MIB-1 proliferation index .
24587882	0	p16	68,71	FHIT	57,61	p16	FHIT	1029	2272	Gene	Gene	Gene|appos|START_ENTITY Gene|compound|END_ENTITY	Loss of Heterozygosities in Five Tumor Suppressor Genes -LRB- FHIT Gene , p16 , pRb , E-Cadherin and p53 -RRB- in Thyroid_Tumors .
23443045	0	p16	15,18	FOXA1	0,5	p16	FOXA1	1029	3169	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	FOXA1 mediates p16 -LRB- INK4a -RRB- activation during cellular senescence .
10799744	0	p16	8,11	INK4	12,16	p16	INK4	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Loss of p16 -LRB- INK4 -RRB- protein , alone and together with loss of retinoblastoma protein , correlate with hepatocellular_carcinoma progression .
25457887	0	p16	0,3	INK4	4,8	p16	INK4	1029	1029	Gene	Gene	Expression|amod|START_ENTITY Expression|appos|END_ENTITY	p16 -LRB- INK4 -RRB- Expression is not associated with human_papillomavirus_in_oral_lichen_planus .
8910511	0	p16	28,31	INK4	32,36	p16	INK4	1029	1029	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Defective folding of mutant p16 -LRB- INK4 -RRB- proteins encoded by tumor-derived alleles .
10567907	0	p16	34,37	INK4A	38,43	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA methylation and expression of p16 -LRB- INK4A -RRB- gene in pulmonary_adenocarcinoma and anthracosis in background lung .
10649246	0	p16	32,35	INK4A	36,41	p16	INK4A	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Differential_retinoblastoma and p16 -LRB- INK4A -RRB- protein expression in neuroendocrine_tumors of the lung .
10679192	0	p16	94,97	INK4A	98,103	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Retinoic_acid extends the in vitro life span of normal human oral keratinocytes by decreasing p16 -LRB- INK4A -RRB- expression and maintaining telomerase activity .
11165758	0	p16	57,60	INK4A	61,66	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	High frequency of homozygous deletion and methylation of p16 -LRB- INK4A -RRB- gene in oral_squamous_cell_carcinomas .
11171828	0	p16	37,40	INK4A	41,46	p16	INK4A	1029	1029	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Detection of hypermethylation of the p16 -LRB- INK4A -RRB- gene promoter in chronic hepatitis and cirrhosis associated with hepatitis B or C_virus .
11291057	0	p16	18,21	INK4A	22,27	p16	INK4A	1029	1029	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of p16 -LRB- INK4A -RRB- as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri .
12970888	4	p16	602,605	INK4A	606,611	p16	INK4A	1029	1029	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	The methylation status of p16 -LRB- INK4A -RRB- promoter in HT-29 cells was also determined by methylation-specific PCR -LRB- MSP -RRB- .
14500697	0	p16	0,3	INK4A	4,9	p16	INK4A	1029	1029	Gene	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	p16 -LRB- INK4A -RRB- immunohistochemical overexpression in premalignant and malignant_oral_lesions infected with human_papillomavirus .
15312681	0	p16	29,32	INK4A	33,38	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Correlation between p14 -LRB- ARF -RRB- / p16 -LRB- INK4A -RRB- expression and HPV_infection_in_uterine_cervical_cancer .
15312681	8	p16	1116,1119	INK4A	1120,1125	p16	INK4A	1029	1029	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	In four HPV-negative_cancers , reduced expression of p14 -LRB- ARF -RRB- mRNA was detected in two cases -LRB- 50 % -RRB- and reduced p16 -LRB- INK4A -RRB- mRNA in three cases -LRB- 75 % -RRB- .
15381905	0	p16	0,3	INK4A	4,9	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p16 -LRB- INK4A -RRB- expression is related to grade of cin and high-risk human_papillomavirus but does not predict virus clearance after conization or disease outcome .
16175083	0	p16	110,113	INK4A	114,119	p16	INK4A	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Abnormalities of the RB1 pathway in ovarian_serous_papillary_carcinoma as determined by overexpression of the p16 -LRB- INK4A -RRB- protein .
16540739	0	p16	8,11	INK4A	13,18	p16	INK4A	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of p16 -LRB- INK4A -RRB- expression is associated with allelic_imbalance / loss of heterozygosity of chromosome 9p21 in microdissected malignant_peripheral_nerve_sheath_tumors .
17069677	0	p16	10,13	INK4A	14,19	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Study of p16 -LRB- INK4A -RRB- expression and DNA ploidy in HPV-negative_cervical_cancers and precursors -RSB- .
17415114	0	p16	34,37	INK4A	38,43	p16	INK4A	1029	1029	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of p16 -LRB- INK4A -RRB- in normal uterine cervix , nonneoplastic epithelial lesions , and low-grade squamous intraepithelial lesions .
18058237	0	p16	14,17	INK4A	18,23	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of p16 -LRB- INK4A -RRB- gene in human pituitary_tumours .
18346352	0	p16	31,34	INK4A	35,40	p16	INK4A	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- Role of HPV DNA detection and p16 -LRB- INK4A -RRB- protein expression in diagnosis of endocervical_adenocarcinoma -RSB- .
19016326	0	p16	39,42	INK4A	43,48	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Progression of hypermethylation of the p16 -LRB- INK4A -RRB- gene from normal liver to nontumorous liver_and_hepatocellular_carcinoma : an evaluation using quantitative PCR analysis .
19125298	0	p16	22,25	INK4A	26,31	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast_cancer .
19732323	0	p16	56,59	INK4A	60,65	p16	INK4A	1029	1029	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Hepatitis_B_virus X protein induces hypermethylation of p16 -LRB- INK4A -RRB- promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis .
20620135	0	p16	57,60	INK4A	61,66	p16	INK4A	1029	1029	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Hepatitis_B_virus X protein promotes hypermethylation of p16 -LRB- INK4A -RRB- promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis .
20955378	0	p16	34,37	INK4A	38,43	p16	INK4A	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Immunohistochemical expression of p16 -LRB- INK4A -RRB- protein as a helpful marker of a subset of potentially malignant oral epithelial lesions : study on a series with long-term follow-up .
21166704	0	p16	79,82	INK4A	83,88	p16	INK4A	1029	1029	Gene	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	Primary_squamous_cell_carcinoma_of_the_vagina : human_papillomavirus detection , p16 -LRB- INK4A -RRB- overexpression and clinicopathological correlations .
21290054	0	p16	15,18	INK4A	19,24	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Correlation of p16 -LRB- INK4A -RRB- expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical_cancer cells .
21533340	0	p16	85,88	INK4A	89,94	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Growth suppression of non-small_cell_lung_carcinoma cells by the introduction of the p16 -LRB- INK4A -RRB- gene .
21612953	0	p16	34,37	INK4A	38,43	p16	INK4A	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Immunohistochemical expression of p16 -LRB- INK4A -RRB- protein in oral_lichen_planus .
22354873	0	p16	12,15	INK4A	16,21	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of p16 -LRB- INK4A -RRB- expression of oral_squamous_cell_carcinomas in Taiwan : prognostic correlation without relevance to betel quid consumption .
22724384	0	p16	8,11	INK4A	12,17	p16	INK4A	1029	1029	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A novel p16 -LRB- INK4A -RRB- mutation associated with esophageal_squamous_cell_carcinoma in a high risk population .
22924132	0	p16	8,11	INK4A	12,17	p16	INK4A	1029	1029	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of p16 -LRB- INK4A -RRB- in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells .
23226740	0	p16	37,40	INK4A	41,46	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter and histone methylation and p16 -LRB- INK4A -RRB- gene expression in colon_cancer .
25497382	0	p16	38,41	INK4A	42,47	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epigenetic regulation of p14 -LRB- ARF -RRB- and p16 -LRB- INK4A -RRB- expression in cutaneous_and_uveal_melanoma .
25575976	0	p16	36,39	INK4A	40,45	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	High-grade acute organ_toxicity and p16 -LRB- INK4A -RRB- expression as positive prognostic factors in primary radio -LRB- chemo -RRB- therapy for patients with head_and_neck_squamous_cell_carcinoma .
25688737	0	p16	41,44	INK4A	45,50	p16	INK4A	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Frequency and prognostic significance of p16 -LRB- INK4A -RRB- protein overexpression and transcriptionally active human_papillomavirus_infection in laryngeal_squamous_cell_carcinoma .
25908244	0	p16	29,32	INK4A	33,38	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The lncRNA MIR31HG regulates p16 -LRB- INK4A -RRB- expression to modulate senescence .
26927017	0	p16	82,85	INK4A	86,91	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	LncRNA PANDAR regulates the G1/S transition of breast_cancer cells by suppressing p16 -LRB- INK4A -RRB- expression .
9788631	0	p16	20,23	INK4A	25,30	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inactivation of the p16 -LRB- INK4A -RRB- tumor-suppressor gene in pancreatic_duct_lesions : loss of intranuclear expression .
9815612	0	p16	20,23	INK4A	24,29	p16	INK4A	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Characterization of p16 -LRB- INK4A -RRB- expression in multiple_myeloma and plasma_cell_leukemia .
9888465	0	p16	46,49	INK4A	63,68	p16	INK4A	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA methylation in the promoter region of the p16 -LRB- CDKN2/MTS -1 / INK4A -RRB- gene in human breast_tumours .
10469011	0	p16	0,3	INK4a	5,10	p16	INK4a	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p16 -LRB- INK4a , MTS-1 -RRB- gene polymorphism and methylation status in human pituitary_tumours .
10694947	0	p16	29,32	INK4a	34,39	p16	INK4a	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inactivation patterns of the p16 -LRB- INK4a -RRB- gene in oral_squamous_cell_carcinoma cell lines .
10856241	0	p16	68,71	INK4a	72,77	p16	INK4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	JunB suppresses cell proliferation by transcriptional activation of p16 -LRB- INK4a -RRB- expression .
10861481	0	p16	91,94	INK4a	95,100	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Methylation of specific CpG sites in the promoter region could significantly down-regulate p16 -LRB- INK4a -RRB- expression in gastric_adenocarcinoma .
10942530	0	p16	27,30	INK4a	31,36	p16	INK4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of p16 -LRB- INK4a -RRB- in azoxymethane-induced mouse colon_tumorigenesis .
11025365	8	p16	1010,1013	INK4a	1014,1019	p16	INK4a	1029	1029	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	None_of_the_insulinomas carried intragenic p16 -LRB- INK4a -RRB- mutations .
11040180	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p16 -LRB- INK4a -RRB- expression begins early in human colon_neoplasia and correlates inversely with markers of cell proliferation .
11241308	0	p16	8,11	INK4a	12,17	p16	INK4a	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of p16 -LRB- INK4a -RRB- expression correlates with decreased survival in pediatric_osteosarcomas .
11281650	0	p16	146,149	INK4a	150,155	p16	INK4a	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16 -LRB- INK4a -RRB- expression .
11282486	0	p16	34,37	INK4a	38,43	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Correlation between p21 -LRB- waf1 -RRB- and p16 -LRB- INK4a -RRB- expression in hepatocellular_carcinoma .
11485924	0	p16	50,53	INK4a	54,59	p16	INK4a	1029	1029	Gene	Gene	CDKN2A|dep|START_ENTITY CDKN2A|appos|END_ENTITY	Alterations of the tumor suppressor genes CDKN2A -LRB- p16 -LRB- INK4a -RRB- -RRB- , p14 -LRB- ARF -RRB- , CDKN2B -LRB- p15 -LRB- INK4b -RRB- -RRB- , and CDKN2C -LRB- p18 -LRB- INK4c -RRB- -RRB- in atypical and anaplastic_meningiomas .
11706079	0	p16	194,197	INK4a	198,203	p16	INK4a	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical -LSB- corrected -RSB- detection of the alternate INK4a-encoded tumor suppressor protein p14 -LRB- ARF -RRB- in archival human cancers and cell lines using commercial antibodies : correlation with p16 -LRB- INK4a -RRB- expression .
11859122	0	p16	29,32	INK4a	33,38	p16	INK4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	cyclin-dependent|amod|START_ENTITY cyclin-dependent|appos|END_ENTITY	Transgenic expression of the p16 -LRB- INK4a -RRB- cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8 - immature thymocytes .
12170463	0	p16	26,29	INK4a	30,35	p16	INK4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	-LSB- Conditional targeting of p16 -LRB- INK4a -RRB- exon 1a in mouse embryonic stem cells -RSB- .
12538475	0	p16	45,48	INK4a	49,54	p16	INK4a	1029	1029	Gene	Gene	CDKN2A|dep|START_ENTITY CDKN2A|appos|END_ENTITY	Detecting homozygous_deletions in the CDKN2A -LRB- p16 -LRB- INK4a -RRB- -RRB- / ARF -LRB- p14 -LRB- ARF -RRB- -RRB- gene in urinary_bladder_cancer using real-time quantitative PCR .
15138269	0	p16	38,41	INK4a	42,47	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of cellular senescence and p16 -LRB- INK4a -RRB- expression by Id1 and E47 proteins in human diploid fibroblast .
15260845	0	p16	49,52	INK4a	53,58	p16	INK4a	1029	1029	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Aberrant methylation of p14 -LRB- ARF -RRB- , p15 -LRB- INK4b -RRB- and p16 -LRB- INK4a -RRB- genes and location of the primary site in pulmonary_squamous_cell_carcinoma .
15870532	0	p16	35,38	INK4a	39,44	p16	INK4a	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Human_papillomavirus infection and p16 -LRB- INK4a -RRB- protein expression in vulvar_intraepithelial_neoplasia and invasive squamous_cell_carcinoma .
15892997	0	p16	62,65	INK4a	66,71	p16	INK4a	1029	1029	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Expression of the p16 -LRB- INK4a -RRB- gene product , methylation of the p16 -LRB- INK4a -RRB- promoter region and expression of the polycomb-group gene BMI-1 in squamous_cell_lung_carcinoma and premalignant_endobronchial_lesions .
16647956	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	p16 -LRB- INK4a -RRB- promoter methylation and 9p21 allelic loss in colorectal_carcinomas : relation with immunohistochemical p16 -LRB- INK4a -RRB- expression and with tumor budding .
16647956	0	p16	114,117	INK4a	118,123	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p16 -LRB- INK4a -RRB- promoter methylation and 9p21 allelic loss in colorectal_carcinomas : relation with immunohistochemical p16 -LRB- INK4a -RRB- expression and with tumor budding .
16767161	0	p16	19,22	INK4a	23,28	p16	INK4a	1029	1029	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Methylation of the p16 -LRB- INK4a -RRB- promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells .
16820088	0	p16	34,37	INK4a	38,43	p16	INK4a	1029	1029	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of the tumor-suppressor p16 -LRB- INK4a -RRB- within regenerative epithelial crypts in ulcerative_colitis .
16828922	0	p16	51,54	INK4a	55,60	p16	INK4a	1029	1029	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The reduced expression and aberrant methylation of p16 -LRB- INK4a -RRB- in chromate workers with lung_cancer .
16973350	0	p16	14,17	INK4a	18,23	p16	INK4a	1029	1029	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of p16 -LRB- INK4a -RRB- in relation to histopathology and viral load of ` high-risk ' HPV types in cervical neoplastic_lesions .
17046239	0	p16	32,35	INK4a	36,41	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	An immunohistochemical study of p16 -LRB- INK4a -RRB- expression in multistep thyroid tumourigenesis .
17152048	0	p16	14,17	INK4a	18,23	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Comparison of p16 -LRB- INK4a -RRB- expression with p53 alterations in head_and_neck_cancer by tissue microarray analysis .
17192788	0	p16	124,127	INK4a	128,133	p16	INK4a	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	IMP3 is a novel biomarker for adenocarcinoma_in_situ of the uterine cervix : an immunohistochemical study in comparison with p16 -LRB- INK4a -RRB- expression .
17367324	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	Expression|amod|START_ENTITY Expression|appos|END_ENTITY	p16 -LRB- INK4a -RRB- Expression does not predict the outcome of cervical_intraepithelial_neoplasia_grade_2 .
17459456	0	p16	24,27	INK4a	28,33	p16	INK4a	1029	1029	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	A common variant of the p16 -LRB- INK4a -RRB- genetic region is associated with physical function in older people .
17906698	0	p16	21,24	INK4a	25,30	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	P300 plays a role in p16 -LRB- INK4a -RRB- expression and cell cycle arrest .
17989730	0	p16	81,84	INK4a	85,90	p16	INK4a	1029	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Premature senescence of balding dermal papilla cells in vitro is associated with p16 -LRB- INK4a -RRB- expression .
18365017	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	translation|amod|START_ENTITY translation|appos|END_ENTITY	p16 -LRB- INK4a -RRB- translation suppressed by miR-24 .
18692948	0	p16	46,49	INK4a	50,55	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Classical and non-classical HLA molecules and p16 -LRB- INK4a -RRB- expression in precursors lesions and invasive_cervical_cancer .
19100258	0	p16	69,72	INK4a	73,78	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Transition_of_cervical_carcinoma in situ to invasive_cancer : role of p16 INK4a expression in progression and in recurrence .
19196247	0	p16	16,19	INK4a	20,25	p16	INK4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Aging increases p16 INK4a expression in vascular smooth-muscle cells .
19450526	0	p16	28,31	INK4a	32,37	p16	INK4a	1029	1029	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Epigenetic silencing of the p16 -LRB- INK4a -RRB- tumor suppressor is associated with loss of CTCF binding and a chromatin boundary .
19656618	0	p16	88,91	INK4a	92,97	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hepatitis_B_virus X protein overcomes stress-induced premature senescence by repressing p16 -LRB- INK4a -RRB- expression via DNA methylation .
19683687	0	p16	9,12	INK4a	13,18	p16	INK4a	1029	1029	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	Value of p16 -LRB- INK4a -RRB- as a marker of progression/regression in cervical_intraepithelial_neoplasia_grade_1 .
20340136	0	p16	56,59	INK4a	60,65	p16	INK4a	1029	1029	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Predicting functional significance of cancer-associated p16 -LRB- INK4a -RRB- mutations in CDKN2A .
21035853	0	p16	27,30	INK4a	31,36	p16	INK4a	1029	1029	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Quantitative evaluation of p16 -LRB- INK4a -RRB- promoter methylation using pyrosequencing in de novo diffuse_large_B-cell_lymphoma .
21225495	0	p16	29,32	INK4a	34,39	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	High-risk HPV DNA status and p16 -LRB- INK4a -RRB- expression as prognostic markers in patients with squamous_cell_cancer_of_oral_cavity and oropharynx .
21390332	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	suppression|amod|START_ENTITY suppression|appos|END_ENTITY	p16 -LRB- INK4a -RRB- suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms .
21657082	0	p16	132,135	INK4a	136,141	p16	INK4a	1029	1029	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Experimental study of relationship between effect of ginsenoside_Rg1 to delay hematopoietic stem cell senescence and expression of p16 -LRB- INK4a -RRB- -RSB- .
21920875	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p16 -LRB- INK4a -RRB- expression and breast_cancer risk in women with atypical_hyperplasia .
21990227	0	p16	15,18	INK4a	19,24	p16	INK4a	1029	1029	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of p16 -LRB- INK4a -RRB- overexpression with improved outcomes in young patients with squamous_cell_cancers of the oral tongue .
22395468	0	p16	84,87	INK4a	89,94	p16	INK4a	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Histone_deacetylase_3 -LRB- HDAC3 -RRB- participates in the transcriptional repression of the p16 -LRB- INK4a -RRB- gene in mammary gland of the female rat offspring exposed to an early-life high-fat diet .
22419364	0	p16	9,12	INK4a	13,18	p16	INK4a	1029	1029	Gene	Gene	Value|nmod|START_ENTITY Value|appos|END_ENTITY	Value of p16 -LRB- INK4a -RRB- in the diagnosis of low-grade urothelial_carcinoma of the urinary_bladder in urinary cytology .
22489695	0	p16	190,193	INK4a	194,199	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal_squamous_cell_carcinoma , with emphasis on smoking , protein p16 -LRB- INK4a -RRB- expression , and HPV status .
22738669	0	p16	14,17	INK4a	18,23	p16	INK4a	1029	1029	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of p16 -LRB- INK4a -RRB- as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy .
22850945	0	p16	17,20	INK4a	21,26	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	An evaluation of p16 -LRB- INK4a -RRB- expression in cervical_intraepithelial_neoplasia specimens , including women with HIV-1 .
22863066	0	p16	148,151	INK4a	152,157	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Identification and genotyping of human_papillomavirus in a Spanish cohort of penile_squamous_cell_carcinomas : correlation with pathologic subtypes , p16 -LRB- INK4a -RRB- expression , and prognosis .
23443045	0	p16	15,18	INK4a	19,24	p16	INK4a	1029	1029	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	FOXA1 mediates p16 -LRB- INK4a -RRB- activation during cellular senescence .
24421848	0	p16	71,74	INK4a	75,80	p16	INK4a	1029	1029	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Primary_Squamous_Cell_Carcinoma of the Upper Genital Tract : Utility of p16 -LRB- INK4a -RRB- Expression and HPV DNA Status in its Differential Diagnosis from Extended Cervical_Squamous_Cell_Carcinoma .
24760498	0	p16	20,23	INK4a	24,29	p16	INK4a	1029	1029	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of protein p16 -LRB- INK4a -RRB- in glottic laryngeal_squamous_cell_carcinoma .
24837742	0	p16	54,57	INK4a	58,63	p16	INK4a	1029	1029	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Methylation of CpG island of p14 -LRB- ARK -RRB- , p15 -LRB- INK4b -RRB- and p16 -LRB- INK4a -RRB- genes in coke oven workers .
24839133	0	p16	34,37	INK4a	38,43	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human_papillomavirus DNA load and p16 -LRB- INK4a -RRB- expression predict for local control in patients with anal_squamous_cell_carcinoma treated with chemoradiotherapy .
24908414	0	p16	49,52	INK4a	54,59	p16	INK4a	1029	1029	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Aberrant promoter methylation of p15 -LRB- INK4b -RRB- and p16 -LRB- INK4a -RRB- genes may contribute to the pathogenesis of multiple_myeloma : a meta-analysis .
24937448	0	p16	169,172	INK4a	173,178	p16	INK4a	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16 -LRB- INK4a -RRB- gene in human colorectal_carcinoma -LRB- Caco-2 -RRB- cells .
25257576	0	p16	157,160	INK4a	161,166	p16	INK4a	1029	1029	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	No evidence of oncogenic KRAS mutations in squamous_cell_carcinomas of the anogenital tract and head and neck region independent of human_papillomavirus and p16 -LRB- INK4a -RRB- status .
25499675	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	p16 INK4a expression in retinoblastoma : a marker of differentiation grade .
25542698	0	p16	55,58	INK4a	59,64	p16	INK4a	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Quantitative analysis of CDKN2A methylation , mRNA , and p16 -LRB- INK4a -RRB- protein expression in children and adolescents with Burkitt_lymphoma : Biological and clinical implications .
25885064	0	p16	32,35	INK4a	36,41	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The role of histologic subtype , p16 -LRB- INK4a -RRB- expression , and presence of human_papillomavirus DNA in penile_squamous_cell_carcinoma .
25923845	0	p16	16,19	INK4a	20,25	p16	INK4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Ablation of the p16 -LRB- INK4a -RRB- tumour suppressor reverses ageing phenotypes of klotho mice .
26268412	0	p16	94,97	INK4a	98,103	p16	INK4a	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- The natural history of cervical_intraepithelial_neoplasia_I and the clinical significance of p16 -LRB- INK4a -RRB- protein as a marker of progression in cervical_intraepithelial_neoplasia_I -RSB- .
26622834	0	p16	65,68	INK4a	69,74	p16	INK4a	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Effect of phosphorylation and methylation on the function of the p16 -LRB- INK4a -RRB- protein in non-small_cell_lung_cancer A549 cells .
26731175	0	p16	92,95	INK4a	96,101	p16	INK4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tenofovir/emtricitabine metabolites and endogenous nucleotide exposures are associated with p16 -LRB- INK4a -RRB- expression in subjects on combination therapy .
26835415	0	p16	122,125	INK4a	127,132	p16	INK4a	1029	1029	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	The rs11515 Polymorphism Is More Frequent and Associated With Aggressive_Breast_Tumors with Increased ANRIL and Decreased p16 -LRB- INK4a -RRB- Expression .
26940728	0	p16	96,99	INK4a	100,105	p16	INK4a	1029	1029	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	A pilot study to compare the detection of HPV-16 biomarkers in salivary oral rinses with tumour p16 -LRB- INK4a -RRB- expression in head_and_neck_squamous_cell_carcinoma patients .
9531609	0	p16	0,3	INK4a	4,9	p16	INK4a	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p16 -LRB- INK4a -RRB- gene inactivation by deletions , mutations , and hypermethylation is associated with transformed and aggressive_variants_of_non-Hodgkin 's _ lymphomas .
15138269	0	p16	38,41	Id1	63,66	p16	Id1	1029	3397	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of cellular senescence and p16 -LRB- INK4a -RRB- expression by Id1 and E47 proteins in human diploid fibroblast .
9704925	0	p16	33,36	Ink4	19,23	p16	Ink4	1029	1029	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Involvement of the Ink4 proteins p16 and p15 in T-lymphocyte senescence .
10964101	0	p16	24,27	Ink4a	29,34	p16	Ink4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Hypermethylation of the p16 -LRB- Ink4a -RRB- promoter in B6C3F1 mouse primary lung_adenocarcinomas and mouse lung cell lines .
11163109	0	p16	19,22	Ink4a	23,28	p16	Ink4a	1029	1029	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Methylation of the p16 -LRB- Ink4a -RRB- tumor suppressor gene 5 ' - CpG island in breast_cancer .
15534905	0	p16	61,64	Ink4a	65,70	p16	Ink4a	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Microarray-based method for detecting methylation changes of p16 -LRB- Ink4a -RRB- gene 5 ' - CpG islands in gastric_carcinomas .
21423154	0	p16	25,28	Ink4a	29,34	p16	Ink4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Up and downregulation of p16 -LRB- Ink4a -RRB- expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon_cancer .
22659510	0	p16	80,83	Ink4a	84,89	p16	Ink4a	25163(Tax:10116)	25163(Tax:10116)	Gene	Gene	Cdkn2a|dep|START_ENTITY Cdkn2a|appos|END_ENTITY	Disruptive cell cycle regulation involving epigenetic downregulation of Cdkn2a -LRB- p16 -LRB- Ink4a -RRB- -RRB- in early-stage liver_tumor-promotion facilitating liver cell regeneration in rats .
26509911	0	p16	0,3	MDM2	45,49	p16	MDM2	1029	4193	Gene	Gene	Immunohistochemistry|compound|START_ENTITY Useful|nsubj|Immunohistochemistry Useful|nmod|END_ENTITY	p16 Immunohistochemistry is Less Useful Than MDM2 and CDK4 to Distinguish Dedifferentiated_Liposarcomas From Other Retroperitoneal Mimics .
25908244	0	p16	29,32	MIR31HG	11,18	p16	MIR31HG	1029	554202	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The lncRNA MIR31HG regulates p16 -LRB- INK4A -RRB- expression to modulate senescence .
9222307	0	p16	30,33	MTS-1	35,40	p16	MTS-1	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Infrequent alterations of the p16 -LRB- MTS-1 -RRB- gene in human gastric_cancer .
7563391	0	p16	19,22	MTS1	24,28	p16	MTS1	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alterations of the p16 -LRB- MTS1 -RRB- gene in testicular , ovarian , and endometrial_malignancies .
7726912	0	p16	59,62	MTS1	64,68	p16	MTS1	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequent somatic mutations and homozygous deletions of the p16 -LRB- MTS1 -RRB- gene in pancreatic_adenocarcinoma .
9212218	0	p16	43,46	MTS1	48,52	p16	MTS1	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Loss of heterozygosity on chromosome 9 and p16 -LRB- MTS1 , CDKN2 -RRB- gene mutations in esophageal_cancers .
9531999	0	p16	58,61	MTS1	62,66	p16	MTS1	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Expression of cyclin_D1 , retinoblastoma gene protein , and p16 MTS1 protein in atypical_adenomatous_hyperplasia and adenocarcinoma_of_the_lung .
17906698	0	p16	21,24	P300	0,4	p16	P300	1029	2033	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression plays|dobj|role plays|nsubj|END_ENTITY	P300 plays a role in p16 -LRB- INK4a -RRB- expression and cell cycle arrest .
19181545	0	p16	131,134	RASSF1A	141,148	p16	RASSF1A	1029	11186	Gene	Gene	genes|dep|START_ENTITY genes|nummod|END_ENTITY	Increase sensitivity in detecting superficial , low grade bladder_cancer by combination analysis of hypermethylation of E-cadherin , p16 , p14 , RASSF1A genes in urine .
25580951	0	p16	31,34	Sal-like_protein_2	0,18	p16	Sal-like protein 2	1029	6297	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Sal-like_protein_2 upregulates p16 expression through a proximal promoter element .
26487755	0	p16	108,111	TGFb	89,93	p16	TGFb	1029	7040	Gene	Gene	Expression|amod|START_ENTITY Regulation|nmod|Expression Regulation|compound|END_ENTITY	9p21 .3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent TGFb Regulation of p16 Expression in Human Aortic Smooth Muscle Cells .
16204053	0	p16	145,148	VEGF	64,68	p16	VEGF	12578(Tax:10090)	22339(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY latent|nmod|up-regulation latent|dep|END_ENTITY	Epstein-Barr_virus latent membrane protein 1 -LRB- CAO -RRB- up-regulates VEGF and TGF_alpha concomitant with hyperlasia , with subsequent up-regulation of p16 and MMP9 .
16998811	0	p16	60,63	VEGF	43,47	p16	VEGF	1029	7422	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
20307196	0	p16	0,3	VEGF	14,18	p16	VEGF	12578(Tax:10090)	22339(Tax:10090)	Gene	Gene	Modulates|amod|START_ENTITY END_ENTITY|nsubj|Modulates	p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast_cancer cells .
11102889	0	p16	89,92	WAF-1	105,110	p16	WAF-1	1029	1026	Gene	Gene	START_ENTITY|appos|p21 p21|appos|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
16998811	0	p16	60,63	WAF1	87,91	p16	WAF1	1029	1026	Gene	Gene	START_ENTITY|appos|p21 p21|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
26849661	0	p16	96,99	b-Catenin	0,9	p16	b-Catenin	1029	1499	Gene	Gene	Comparison|nmod|START_ENTITY Expression|dep|Comparison Expression|amod|END_ENTITY	b-Catenin Expression in Oropharyngeal_Squamous_Cell_Carcinomas : Comparison and Correlation with p16 and Human_Papillomavirus in situ Hybridization .
26493274	0	p16	105,108	b-catenin	125,134	p16	b-catenin	1029	1499	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	A novel prediction model for human_papillomavirus-associated oropharyngeal_squamous_cell_carcinoma using p16 and subcellular b-catenin expression .
17442375	0	p16	16,19	bmi-1	113,118	p16	bmi-1	1029	648	Gene	Gene	inactivation|amod|START_ENTITY Consequences|nmod|inactivation syndrome|nsubj|Consequences syndrome|nmod|oncogenes oncogenes|amod|END_ENTITY	Consequences of p16 tumor suppressor gene inactivation in mycosis fungoides and S zary syndrome and role of the bmi-1 and ras oncogenes in disease progression .
19575869	0	p16	36,39	c-myc	24,29	p16	c-myc	1029	4609	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	-LSB- Abnormal expression of c-myc , p53 , p16 protein and GNAS1 gene mutation in fibrous_dysplasia -RSB- .
19624419	0	p16	72,75	cyclin_A	52,60	p16	cyclin A	1029	890	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
12378511	0	p16	36,39	cyclin_D1	46,55	p16	cyclin D1	1029	595	Gene	Gene	p27|dep|START_ENTITY p27|dep|END_ENTITY	Expression of G1-S modulators -LRB- p53 , p16 , p27 , cyclin_D1 , Rb -RRB- and Smad4/Dpc4 in intrahepatic_cholangiocarcinoma .
17060721	0	p16	24,27	cyclin_D1	29,38	p16	cyclin D1	1029	595	Gene	Gene	esophageal_squamous_cell_carcinoma|dep|START_ENTITY esophageal_squamous_cell_carcinoma|nummod|END_ENTITY	-LSB- The expression of p53 , p16 , cyclin_D1 in esophageal_squamous_cell_carcinoma and esophageal_dysplasia -RSB- .
19624419	0	p16	72,75	cyclin_D1	41,50	p16	cyclin D1	1029	595	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
21799732	0	p16	0,3	cyclin_D1	33,42	p16	cyclin D1	1029	595	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p16 -LRB- INK4a -RRB- positively regulates cyclin_D1 and E2F1 through negative control of AUF1 .
25189115	0	p16	121,124	cyclin_D1	127,136	p16	cyclin D1	1029	595	Gene	Gene	CDK4|amod|START_ENTITY CDK4|dep|END_ENTITY	Duhuo Jisheng Decoction - containing serum promotes proliferation of interleukin __ -1 b - induced chondrocytes through the p16 - cyclin_D1 / CDK4 - Rb pathway .
10738246	0	p16	8,11	ink4	12,16	p16	ink4	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Ectopic p16 -LRB- ink4 -RRB- expression enhances CPT-11-induced apoptosis through increased delay in S-phase progression in human non-small-cell-lung-cancer cells .
11920642	0	p16	19,22	ink4a	23,28	p16	ink4a	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alterations of the p16 -LRB- ink4a -RRB- gene in resected nonsmall_cell_lung_tumors and exfoliated cells within sputum .
17393105	0	p16	21,24	ink4a	25,30	p16	ink4a	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of exogenous p16 -LRB- ink4a -RRB- gene on biological behaviors of human lung_cancer cells .
18418881	0	p16	31,34	ink4a	35,40	p16	ink4a	1029	1029	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Immunocytochemical staining of p16 -LRB- ink4a -RRB- protein as an adjunct test in equivocal liquid-based cytology .
21775818	0	p16	15,18	ink4a	19,24	p16	ink4a	1029	1029	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The meaning of p16 -LRB- ink4a -RRB- expression in tumors : functional significance , clinical associations and future developments .
16575904	0	p16	0,3	matrix_metalloproteinase-2	13,39	p16	matrix metalloproteinase-2	1029	4313	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	p16 inhibits matrix_metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription .
17395400	0	p16	64,67	mdm2	74,78	p16	mdm2	1029	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
11314047	0	p16	110,113	p14	64,67	p16	p14	1029	1029	Gene	Gene	inactivation|nmod|START_ENTITY END_ENTITY|nmod|inactivation	Quantitative real-time PCR does not show selective targeting of p14 -LRB- ARF -RRB- but concomitant inactivation of both p16 -LRB- INK4A -RRB- and p14 -LRB- ARF -RRB- in 105 human primary_gliomas .
16115229	0	p16	75,78	p14	90,93	p16	p14	1029	1029	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
16258956	0	p16	87,90	p14	111,114	p16	p14	1029	1029	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|amod|END_ENTITY	Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors -LSB- p16 -LRB- INK4a -RRB- , p15 -LRB- INK4b -RRB- , p14 -LRB- ARF -RRB- -RSB- in mantle_cell_lymphoma .
17395400	0	p16	64,67	p14	59,62	p16	p14	1029	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
26255234	0	p16	17,20	p14	8,11	p16	p14	1029	1029	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	CDKN2A -LRB- p14 -LRB- ARF -RRB- / p16 -LRB- INK4a -RRB- -RRB- and ATM promoter methylation in patients with impalpable breast_lesions .
10641574	0	p16	98,101	p15	87,90	p16	p15	1029	1030	Gene	Gene	/|dobj|START_ENTITY END_ENTITY|acl|/	The incidence of chromosome 9p21 abnormalities and deletions of tumor suppressor genes p15 -LRB- INK4b -RRB- / p16 -LRB- INK4a -RRB- / p14 -LRB- ARF -RRB- in patients with acute_lymphoblastic_leukemia .
12894891	0	p16	33,36	p15	37,40	p16	p15	1029	1030	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Deletions and point mutations of p16 , p15 gene in primary_tumors and tumor cell lines .
15469082	0	p16	74,77	p15	69,72	p16	p15	1029	1030	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	-LSB- Expression of survivin gene and its relationship with expression of p15 , p16 proteins in laryngeal_squamous_cell_carcinomas -RSB- .
15892297	0	p16	15,18	p15	4,7	p16	p15	1029	1030	Gene	Gene	INK4b|dep|START_ENTITY INK4b|amod|END_ENTITY	The p15 -LRB- INK4b -RRB- / p16 -LRB- INK4a -RRB- / RB1 pathway is frequently deregulated in human pituitary_adenomas .
19837270	0	p16	31,34	p15	53,56	p16	p15	1029	1030	Gene	Gene	CDKN2A|dep|START_ENTITY CDKN2A|appos|END_ENTITY	Homozygous deletion of CDKN2A -LRB- p16 , p14 -RRB- and CDKN2B -LRB- p15 -RRB- genes is a poor prognostic factor in adult but not in childhood B-lineage acute_lymphoblastic_leukemia : a comparative deletion and hypermethylation study .
8847892	0	p16	92,95	p15	103,106	p16	p15	1029	1030	Gene	Gene	START_ENTITY|dep|suppressor suppressor|amod|END_ENTITY	A novel pre-B acute_lymphoblastic_leukemia cell line with chromosomal translocation between p16 -LRB- INK4A -RRB- / p15 -LRB- INK4B -RRB- tumor suppressor and immunoglobulin heavy chain genes : TGFbeta/IL -7 inhibitory signaling mechanism .
9164185	0	p16	24,27	p15	13,16	p16	p15	1029	1030	Gene	Gene	genes|amod|START_ENTITY and/or|dobj|genes and/or|nsubj|Deletions Deletions|nmod|END_ENTITY	Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult_T-cell_leukemia .
9624535	0	p16	22,25	p15	34,37	p16	p15	1029	1030	Gene	Gene	CDKN2A|appos|START_ENTITY Association|nmod|CDKN2A Association|parataxis|alterations alterations|nsubj|CDKN2B CDKN2B|appos|END_ENTITY	Association of CDKN2A -LRB- p16 -RRB- / CDKN2B -LRB- p15 -RRB- alterations and homozygous chromosome arm 9p deletions in human lung_carcinoma .
11598130	0	p16	114,117	p16	66,69	p16	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of regulatory elements on the promoter region of p16 -LRB- INK4a -RRB- that contribute to overexpression of p16 in senescent fibroblasts .
11598130	0	p16	66,69	p16	114,117	p16	p16	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of regulatory elements on the promoter region of p16 -LRB- INK4a -RRB- that contribute to overexpression of p16 in senescent fibroblasts .
10071127	0	p16	29,32	p21	24,27	p16	p21	1029	644914	Gene	Gene	p15|dep|START_ENTITY p15|dep|END_ENTITY	Alterations of the p53 , p21 , p16 , p15 and RAS genes in childhood_T-cell_acute_lymphoblastic_leukemia .
10207115	0	p16	84,87	p21	13,16	p16	p21	1029	1026	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Induction Induction|nmod|END_ENTITY	Induction of p21 -LRB- WAF1/CIP1 -RRB- and inhibition of Cdk2 mediated by the tumor suppressor p16 -LRB- INK4a -RRB- .
15094066	0	p16	53,56	p21	66,69	p16	p21	1029	1026	Gene	Gene	activation|nmod|START_ENTITY involved|nmod|activation involved|nmod|Waf1 Waf1|amod|END_ENTITY	Sp1 is involved in the transcriptional activation of p16 -LRB- INK4 -RRB- by p21 -LRB- Waf1 -RRB- in HeLa cells .
16014626	0	p16	97,100	p21	51,54	p16	p21	1029	1026	Gene	Gene	up-regulation|compound|START_ENTITY induces|nmod|up-regulation induces|dobj|redistribution redistribution|nmod|END_ENTITY	Hepatocyte_growth_factor induces redistribution of p21 -LRB- CIP1 -RRB- and p27 -LRB- KIP1 -RRB- through ERK-dependent p16 -LRB- INK4a -RRB- up-regulation , leading to cell cycle arrest at G1 in HepG2 hepatoma cells .
16115229	0	p16	75,78	p21	80,83	p16	p21	1029	644914	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p16	64,67	p21	49,52	p16	p21	1029	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19624419	0	p16	72,75	p21	67,70	p16	p21	1029	1026	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
23754829	0	p16	63,66	p21	75,78	p16	p21	1029	1026	Gene	Gene	significance|nmod|START_ENTITY evaluation|nmod|significance /|nsubj|evaluation /|dobj|WAF1/Cip1 WAF1/Cip1|amod|END_ENTITY	An evaluation of the diagnostic and prognostic significance of p16 -LRB- INK4a -RRB- / p21 -LRB- WAF1/Cip1 -RRB- immunostaining in squamous_intraepithelial_lesions of the uterine cervix using liquid-based cytology specimens .
23894605	0	p16	0,3	p21	32,35	p16	p21	1029	1026	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	p16 -LRB- INK4A -RRB- positively regulates p21 -LRB- WAF1 -RRB- expression by suppressing AUF1-dependent mRNA decay .
26422859	0	p16	54,57	p21	59,62	p16	p21	1029	1026	Gene	Gene	START_ENTITY|appos|Bax Bax|nummod|END_ENTITY	Determination-of apoptosis and cell cycle modulators -LRB- p16 , p21 , p27 , p53 , BCL-2 , Bax , BCL-xL , and cyclin_D1 -RRB- in thyroid_follicular_carcinoma , follicular_adenoma , and adenomatous nodules via a tissue microarray method .
10226946	0	p16	63,66	p27	78,81	p16	p27	1029	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
12960127	0	p16	8,11	p27	27,30	p16	p27	1029	3429	Gene	Gene	Loss|nmod|START_ENTITY contributes|nsubj|Loss contributes|nmod|sequestration sequestration|amod|END_ENTITY	Loss of p16 contributes to p27 sequestration by cyclin D -LRB- 1 -RRB- - cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular_carcinoma .
16115229	0	p16	75,78	p27	85,88	p16	p27	1029	10671	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p16	64,67	p27	54,57	p16	p27	1029	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19624419	0	p16	72,75	p27	62,65	p16	p27	1029	3429	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
10071127	0	p16	29,32	p53	19,22	p16	p53	1029	7157	Gene	Gene	p15|dep|START_ENTITY p15|compound|END_ENTITY	Alterations of the p53 , p21 , p16 , p15 and RAS genes in childhood_T-cell_acute_lymphoblastic_leukemia .
10226946	0	p16	63,66	p53	73,76	p16	p53	1029	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
10797439	0	p16	37,40	p53	32,35	p16	p53	1029	7157	Gene	Gene	INK4A|amod|START_ENTITY INK4A|dep|END_ENTITY	Investigation of germline PTEN , p53 , p16 -LRB- INK4A -RRB- / p14 -LRB- ARF -RRB- , and CDK4 alterations in familial_glioma .
10922393	0	p16	20,23	p53	46,49	p16	p53	1029	7157	Gene	Gene	Absence|nmod|START_ENTITY alterations|nsubj|Absence alterations|nmod|families families|nummod|END_ENTITY	Absence of germline p16 -LRB- INK4a -RRB- alterations in p53 wild type Li-Fraumeni_syndrome families .
10986054	0	p16	28,31	p53	66,69	p16	p53	1029	7157	Gene	Gene	INK4a|amod|START_ENTITY INK4a|dep|hypermethylation hypermethylation|appos|mutation mutation|compound|END_ENTITY	Differential frequencies of p16 -LRB- INK4a -RRB- promoter hypermethylation , p53 mutation , and K-ras mutation in exfoliative material mark the development of lung_cancer in symptomatic chronic smokers .
11115575	0	p16	53,56	p53	48,51	p16	p53	1029	7157	Gene	Gene	K-ras|nummod|START_ENTITY K-ras|nummod|END_ENTITY	Characterization of the mutations of the K-ras , p53 , p16 , and SMAD4 genes in 15 human pancreatic_cancer cell lines .
11205312	0	p16	58,61	p53	38,41	p16	p53	1029	7157	Gene	Gene	-1|nummod|START_ENTITY proteins|compound|-1 proteins|compound|END_ENTITY	Immunohistochemical expression of the p53 , p21/Waf -1 , Rb , p16 and Ki67 proteins in multiple_myeloma .
11733961	0	p16	26,29	p53	105,108	p16	p53	1029	7157	Gene	Gene	gene|amod|START_ENTITY expression|nmod|gene Loss|nmod|expression frequent|nsubj|Loss frequent|xcomp|lacking lacking|dobj|mutations mutations|compound|END_ENTITY	Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian_cancers lacking p53 mutations .
11756558	0	p16	19,22	p53	43,46	p16	p53	12578(Tax:10090)	22060(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Obligate roles for p16 -LRB- Ink4a -RRB- and p19 -LRB- Arf -RRB- - p53 in the suppression of murine pancreatic neoplasia .
11776846	0	p16	21,24	p53	57,60	p16	p53	1029	7157	Gene	Gene	gene|amod|START_ENTITY gene|nmod|growth growth|nmod|cells cells|compound|END_ENTITY	-LSB- Effect of exogenous p16 gene on the growth of wild-type p53 human lung_adenocarcinoma cells -RSB- .
11777345	0	p16	29,32	p53	23,26	p16	p53	1029	7157	Gene	Gene	INK4a|amod|START_ENTITY -|appos|INK4a -|compound|END_ENTITY	Expression profiles of p53 - , p16 -LRB- INK4a -RRB- - , and telomere-regulating genes in replicative senescent primary human , mouse , and chicken fibroblast cells .
11866886	0	p16	1,4	p53	6,9	p16	p53	1029	7157	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	-LSB- p16 , p53 and c-erbB-2 gene expression in bladder_carcinoma -RSB- .
12378511	0	p16	36,39	p53	31,34	p16	p53	1029	7157	Gene	Gene	p27|dep|START_ENTITY p27|compound|END_ENTITY	Expression of G1-S modulators -LRB- p53 , p16 , p27 , cyclin_D1 , Rb -RRB- and Smad4/Dpc4 in intrahepatic_cholangiocarcinoma .
14556194	0	p16	39,42	p53	64,67	p16	p53	12578(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	-LSB- Research on expression and control of p16 and p21 by wild-type p53 gene in two lung_adenocarcinoma cell lines -RSB- .
16489012	0	p16	69,72	p53	40,43	p16	p53	1029	7157	Gene	Gene	bypass|amod|START_ENTITY V12|appos|bypass V12|appos|knockdown knockdown|compound|END_ENTITY	Multiple oncogenic changes -LRB- K-RAS -LRB- V12 -RRB- , p53 knockdown , mutant EGFRs , p16 bypass , telomerase -RRB- are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells .
16948516	0	p16	63,66	p53	68,71	p16	p53	1029	7157	Gene	Gene	pRb|compound|START_ENTITY pRb|dep|END_ENTITY	Upper aerodigestive tract squamous dysplasia : correlation with p16 , p53 , pRb , and Ki-67 expression .
16998811	0	p16	60,63	p53	55,58	p16	p53	1029	7157	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17060721	0	p16	24,27	p53	19,22	p16	p53	1029	7157	Gene	Gene	esophageal_squamous_cell_carcinoma|dep|START_ENTITY esophageal_squamous_cell_carcinoma|compound|END_ENTITY	-LSB- The expression of p53 , p16 , cyclin_D1 in esophageal_squamous_cell_carcinoma and esophageal_dysplasia -RSB- .
17152048	0	p16	14,17	p53	41,44	p16	p53	1029	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Comparison of p16 -LRB- INK4a -RRB- expression with p53 alterations in head_and_neck_cancer by tissue microarray analysis .
17395400	0	p16	64,67	p53	69,72	p16	p53	1029	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
18021213	0	p16	14,17	p53	96,99	p16	p53	1029	7157	Gene	Gene	infection|amod|START_ENTITY Expression|nmod|infection related|nsubjpass|Expression related|nmod|activity activity|compound|END_ENTITY	Expression of p16 and cervical infection with high-risk human_papillomavirus are not related to p53 activity in cervical_intraepithelial_neoplasia .
19148359	0	p16	6,9	p53	1,4	p16	p53	1029	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	-LSB- p53 , p16 E COX-2 expression in esophageal_squamous_cell_carcinoma and histopathological association -RSB- .
19575869	0	p16	36,39	p53	31,34	p16	p53	1029	7157	Gene	Gene	protein|dep|START_ENTITY protein|dep|END_ENTITY	-LSB- Abnormal expression of c-myc , p53 , p16 protein and GNAS1 gene mutation in fibrous_dysplasia -RSB- .
20416157	0	p16	22,25	p53	27,30	p16	p53	1029	7157	Gene	Gene	START_ENTITY|appos|transfection transfection|compound|END_ENTITY	-LSB- Inhibitory effect of p16 , p53 transfection on leukemic cell lines K562 and HL-60 -RSB- .
24178677	0	p16	43,46	p53	48,51	p16	p53	1029	7157	Gene	Gene	Proteins|nummod|START_ENTITY Proteins|nummod|END_ENTITY	Expression of Cell Cycle-Related Proteins , p16 , p53 and p63 as Important Prognostic Markers in Gallbladder_Adenocarcinoma .
25201325	0	p16	78,81	p53	58,61	p16	p53	1029	7157	Gene	Gene	overexpression|amod|START_ENTITY expression|appos|overexpression expression|compound|END_ENTITY	Human_papillomavirus infection in Bowen_disease : Negative p53 expression , not p16 -LRB- INK -RRB- _ -LRB- 4a -RRB- overexpression , is correlated with human_papillomavirus-associated Bowen_disease .
25857071	0	p16	23,26	p53	18,21	p16	p53	1029	7157	Gene	Gene	DPC4|dep|START_ENTITY DPC4|compound|END_ENTITY	-LSB- Oncogene -LRB- K-ras , p53 , p16 , DPC4 , hTERTmRNA -RRB- -RSB- .
25916534	0	p16	38,41	p53	43,46	p16	p53	1029	7157	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	-LSB- Clinical features and expressions of p16 , p53 protein of human_papillomavirus-related tonsillar_carcinoma -RSB- .
25916534	0	p16	38,41	p53	43,46	p16	p53	1029	7157	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	-LSB- Clinical features and expressions of p16 , p53 protein of human_papillomavirus-related tonsillar_carcinoma -RSB- .
26398519	0	p16	90,93	p53	95,98	p16	p53	1029	7157	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	In situ carcinoma developed over_oral_lichen_planus : a case report with analysis of BUB3 , p16 , p53 , Ki67 and SOX4 expression .
7473071	0	p16	21,24	p53	55,58	p16	p53	1029	7157	Gene	Gene	protein|amod|START_ENTITY location|nmod|protein location|nmod|protein protein|compound|END_ENTITY	Abnormal location of p16 protein and overexpression of p53 protein in human radiation-induced skin_cancer .
8674005	0	p16	36,39	p53	31,34	p16	p53	1029	7157	Gene	Gene	Alterations|appos|START_ENTITY Alterations|appos|END_ENTITY	Alterations of retinoblastoma , p53 , p16 -LRB- CDKN2 -RRB- , and p15 genes in human astrocytomas .
9047388	0	p16	19,22	p53	84,87	p16	p53	1029	7157	Gene	Gene	gene|amod|START_ENTITY Alterations|nmod|gene Alterations|dep|frequency frequency|nmod|END_ENTITY	Alterations of the p16 gene in head_and_neck_cancer : frequency and association with p53 , PRAD-1 and HPV .
9210874	0	p16	65,68	p53	17,20	p16	p53	1029	7157	Gene	Gene	expression|amod|START_ENTITY Determination|nmod|expression Determination|nmod|mutations mutations|compound|END_ENTITY	Determination of p53 mutations , EGFR overexpression , and loss of p16 expression in pediatric_glioblastomas .
9490270	0	p16	36,39	p53	51,54	p16	p53	1029	7157	Gene	Gene	9p21|appos|START_ENTITY 9p21|appos|END_ENTITY	Allelic deletion at chromosome 9p21 -LRB- p16 -RRB- and 17p13 -LRB- p53 -RRB- in microdissected sporadic dysplastic_nevus .
10547597	0	p16	14,17	pRB	30,33	p16	pRB	1029	5925	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of p16 and lack of pRB in primary small_cell_lung_cancer .
12016143	0	p16	93,96	pRB	104,107	p16	pRB	1029	5925	Gene	Gene	inactivation|nmod|START_ENTITY serum|nmod|inactivation stimulates|acl:relcl|serum stimulates|dep|END_ENTITY	Id-1 stimulates serum independent prostate_cancer cell proliferation through inactivation of p16 -LRB- INK4a -RRB- / pRB pathway .
12416540	0	p16	47,50	pRB	106,109	p16	pRB	1029	5925	Gene	Gene	expression|nmod|START_ENTITY results|nsubj|expression results|nmod|loss loss|nmod|expression expression|compound|END_ENTITY	Conditional expression of the tumor suppressor p16 in a heterotopic_glioblastoma model results in loss of pRB expression .
25291363	0	p16	119,122	pRB	79,82	p16	pRB	1029	5925	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation , pRB Phosphorylation and Upregulation of p16 and p21 .
10226946	0	p16	63,66	pRb	68,71	p16	pRb	1029	5925	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
16616093	0	p16	0,3	pRb	21,24	p16	pRb	1029	5925	Gene	Gene	START_ENTITY|appos|retinoblastoma retinoblastoma|appos|END_ENTITY	p16 , retinoblastoma -LRB- pRb -RRB- , and cyclin_D1 protein expression in human endometriotic and adenomyotic_lesions .
20703084	0	p16	31,34	pRb	91,94	p16	pRb	1029	5925	Gene	Gene	overexpression|amod|START_ENTITY induced|nmod|overexpression induced|nmod|END_ENTITY	S-phase lengthening induced by p16 -LRB- INK4a -RRB- overexpression in malignant cells with wild-type pRb and p53 .
25675863	0	p16	4,7	pRb	15,18	p16	pRb	1029	5925	Gene	Gene	/|nsubj|START_ENTITY /|ccomp|define define|nsubj|pathway pathway|compound|END_ENTITY	The p16 -LRB- INK4A -RRB- / pRb pathway and telomerase activity define a subgroup of Ph + adult Acute_Lymphoblastic_Leukemia associated with inferior outcome .
7834615	0	p16	10,13	pRb	36,39	p16	pRb	1029	5925	Gene	Gene	levels|amod|START_ENTITY correlate|nsubj|levels correlate|nmod|alterations alterations|compound|END_ENTITY	Increased p16 levels correlate with pRb alterations in human urothelial cells .
7954450	0	p16	75,78	pRb	129,132	p16	pRb	1029	5925	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb .
8674005	0	p16	36,39	retinoblastoma	15,29	p16	retinoblastoma	1029	5925	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of retinoblastoma , p53 , p16 -LRB- CDKN2 -RRB- , and p15 genes in human astrocytomas .
13679459	0	p16	4,7	tumor-suppressor	23,39	p16	tumor-suppressor	1029	7248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The p16 -LRB- CDKN2a/INK4a -RRB- tumor-suppressor gene in head_and_neck_squamous_cell_carcinoma : a promoter methylation and protein expression study in 100 cases .
22705216	0	p16	20,23	tumor-suppressor	24,40	p16	tumor-suppressor	1029	7248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Hypermethylation of p16 tumor-suppressor gene in ameloblastic_carcinoma , ameloblastoma , and dental follicles .
23190892	0	p16	42,45	tumor-suppressor	59,75	p16	tumor-suppressor	1029	7248	Gene	Gene	mutations|nmod|START_ENTITY uncouple|nsubj|mutations uncouple|dobj|functions functions|amod|END_ENTITY	Familial_melanoma-associated mutations in p16 uncouple its tumor-suppressor functions .
9788631	0	p16	20,23	tumor-suppressor	32,48	p16	tumor-suppressor	1029	7248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Inactivation of the p16 -LRB- INK4A -RRB- tumor-suppressor gene in pancreatic_duct_lesions : loss of intranuclear expression .
11823864	0	p160	57,61	CBP/p300	45,53	p160	CBP/p300	10514	1387;2033	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators .
9707430	0	p160ROCK	0,8	RhoA	18,22	p160ROCK	RhoA	6093	387	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|compound|END_ENTITY	p160ROCK mediates RhoA activation of Na-H exchange .
8791272	0	p16INK4	19,26	CDKN2	28,33	p16INK4	CDKN2	1029	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Involvement of the p16INK4 -LRB- CDKN2 -RRB- gene in familial_melanoma .
7585516	0	p16INK4	8,15	pRb	43,46	p16INK4	pRb	1029	5925	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Lack of p16INK4 or retinoblastoma protein -LRB- pRb -RRB- , or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial_tumors and cell lines .
24021343	0	p16INK4A	0,8	EGFR	15,19	p16INK4A	EGFR	1029	1956	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	p16INK4A , p53 , EGFR expression and KRAS mutation status in squamous_cell_cancers of the anus : correlation with outcomes following chemo-radiotherapy .
14651981	0	p16INK4A	88,96	TAL1/SCL	48,56	p16INK4A	TAL1/SCL	12578(Tax:10090)	21349(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	The basic helix-loop-helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTalpha genes .
9488660	0	p16INK4A	34,42	TFIIH	121,126	p16INK4A	TFIIH	1029	2968	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Cyclin-dependent kinase inhibitor p16INK4A inhibits phosphorylation of RNA polymerase II by general transcription factor TFIIH .
8612584	0	p16INK4A	68,76	Tax	7,10	p16INK4A	Tax	1029	6900	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4 .
16858682	0	p16INK4A	13,21	beta-catenin	34,46	p16INK4A	beta-catenin	1029	1499	Gene	Gene	Induction|nmod|START_ENTITY mediated|nsubj|Induction mediated|nmod|END_ENTITY	Induction of p16INK4A mediated by beta-catenin in a TCF4-independent manner : implications for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial_carcinoma cells .
10825132	0	p16INK4A	0,8	cyclin_dependent_kinase_4	18,43	p16INK4A	cyclin dependent kinase 4	1029	1019	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|END_ENTITY	p16INK4A mediates cyclin_dependent_kinase_4 and 6 inhibition in senescent prostatic epithelial cells .
21526487	0	p16INK4A	62,70	p21waf1/cip1	72,84	p16INK4A	p21waf1/cip1	1029	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Effect of human_papillomavirus on cell cycle-related proteins p16INK4A , p21waf1/cip1 , p53 and cyclin_D1 in sinonasal inverted_papilloma and laryngeal_carcinoma .
14981901	0	p16INK4A	45,53	p53	138,141	p16INK4A	p53	1029	7157	Gene	Gene	cycle|dep|START_ENTITY Mutations|nmod|cycle infrequent|nsubj|Mutations infrequent|nmod|status status|compound|END_ENTITY	Mutations of the cell cycle regulatory genes p16INK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal_squamous_cell_carcinomas .
19851199	0	p16INK4A	114,122	p53	124,127	p16INK4A	p53	1029	7157	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Atypical_leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A , p53 , Ki-67 , estrogen receptors , and progesterone receptors .
21526487	0	p16INK4A	62,70	p53	86,89	p16INK4A	p53	1029	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Effect of human_papillomavirus on cell cycle-related proteins p16INK4A , p21waf1/cip1 , p53 and cyclin_D1 in sinonasal inverted_papilloma and laryngeal_carcinoma .
24021343	0	p16INK4A	0,8	p53	10,13	p16INK4A	p53	1029	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	p16INK4A , p53 , EGFR expression and KRAS mutation status in squamous_cell_cancers of the anus : correlation with outcomes following chemo-radiotherapy .
19130399	0	p16INK4A	17,25	pRb	12,15	p16INK4A	pRb	1029	5925	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|appos|proteins	Analysis of pRb , p16INK4A proteins and proliferating antigens : PCNA , Ki-67 and MCM5 expression in aggressive fibromatosis -LRB- desmoid_tumor -RRB- .
18953432	0	p16INK4a	0,8	B-RAF	45,50	p16INK4a	B-RAF	1029	673	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity_in_melanoma_tumors .
21052002	0	p16INK4a	56,64	BMI-1	42,47	p16INK4a	BMI-1	1029	648	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|compound|END_ENTITY	Implication of USP22 in the regulation of BMI-1 , c-Myc , p16INK4a , p14ARF , and cyclin_D2 expression in primary colorectal_carcinomas .
22509111	0	p16INK4a	19,27	Bmi1	50,54	p16INK4a	Bmi1	1029	648	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	High expression of p16INK4a and low expression of Bmi1 are associated with endothelial cellular senescence in the human cornea .
10465111	0	p16INK4a	39,47	CDK4	49,53	p16INK4a	CDK4	1029	1019	Gene	Gene	N-ras|nummod|START_ENTITY N-ras|nummod|END_ENTITY	Mutational analysis of the N-ras , p53 , p16INK4a , CDK4 , and MC1R genes in human congenital_melanocytic_naevi .
9462707	0	p16INK4a	25,33	CDKN2A	17,23	p16INK4a	CDKN2A	1029	1029	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mutations in the CDKN2A -LRB- p16INK4a -RRB- gene in microdissected sporadic primary melanomas .
9751050	0	p16INK4a	93,101	Cdk6	63,67	p16INK4a	Cdk6	1029	1021	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a .
11753042	0	p16INK4a	0,8	MDM2	100,104	p16INK4a	MDM2	1029	4193	Gene	Gene	marker|nsubj|START_ENTITY marker|dep|analysis analysis|nmod|p16INK4a p16INK4a|appos|END_ENTITY	p16INK4a is a prognostic marker in resected_ductal_pancreatic_cancer : an analysis of p16INK4a , p53 , MDM2 , an Rb .
8973369	0	p16INK4a	58,66	MTS1	68,72	p16INK4a	MTS1	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 5 ' - flanking region of the E1 alpha form of the murine p16INK4a -LRB- MTS1 -RRB- gene .
11172613	0	p16INK4a	35,43	N-ras	23,28	p16INK4a	N-ras	1029	4893	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|compound|END_ENTITY	Mutational analysis of N-ras , p53 , p16INK4a , p14ARF and CDK4 genes in primary human malignant mesotheliomas .
24163379	0	p16INK4a	38,46	Sp1	94,97	p16INK4a	Sp1	1029	6667	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The cyclin-dependent kinase inhibitor p16INK4a physically interacts with transcription factor Sp1 and cyclin-dependent_kinase_4 to transactivate microRNA-141 and microRNA-146b-5p spontaneously and in response to ultraviolet light-induced DNA damage .
21052002	0	p16INK4a	56,64	c-Myc	49,54	p16INK4a	c-Myc	1029	4609	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|dep|END_ENTITY	Implication of USP22 in the regulation of BMI-1 , c-Myc , p16INK4a , p14ARF , and cyclin_D2 expression in primary colorectal_carcinomas .
22521293	0	p16INK4a	14,22	endothelin-1	61,73	p16INK4a	endothelin-1	1029	1906	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|amod|END_ENTITY	ETS-dependent p16INK4a and p21waf1/cip1 gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells .
12209876	0	p16INK4a	32,40	hnRNP_A1	55,63	p16INK4a	hnRNP A1	1029	3178	Gene	Gene	START_ENTITY|nmod|proteins proteins|compound|END_ENTITY	Modulation of the expression of p16INK4a and p14ARF by hnRNP_A1 and A2 RNA binding proteins : implications for cellular senescence .
21896275	0	p16INK4a	42,50	p33ING1b	21,29	p16INK4a	p33ING1b	1029	3621	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence .
10465111	0	p16INK4a	39,47	p53	34,37	p16INK4a	p53	1029	7157	Gene	Gene	N-ras|nummod|START_ENTITY N-ras|nummod|END_ENTITY	Mutational analysis of the N-ras , p53 , p16INK4a , CDK4 , and MC1R genes in human congenital_melanocytic_naevi .
11172613	0	p16INK4a	35,43	p53	30,33	p16INK4a	p53	1029	7157	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|dep|END_ENTITY	Mutational analysis of N-ras , p53 , p16INK4a , p14ARF and CDK4 genes in primary human malignant mesotheliomas .
11753042	0	p16INK4a	0,8	p53	95,98	p16INK4a	p53	1029	7157	Gene	Gene	marker|nsubj|START_ENTITY marker|dep|analysis analysis|nmod|p16INK4a p16INK4a|appos|END_ENTITY	p16INK4a is a prognostic marker in resected_ductal_pancreatic_cancer : an analysis of p16INK4a , p53 , MDM2 , an Rb .
16243918	0	p16INK4a	16,24	p53	130,133	p16INK4a	p53	1029	7157	Gene	Gene	pathways|amod|START_ENTITY Contribution|nmod|pathways Contribution|dep|role role|nmod|END_ENTITY	Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells : permissive role of p53 .
17079452	0	p16INK4a	0,8	p53	19,22	p16INK4a	p53	1029	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|END_ENTITY	p16INK4a modulates p53 in primary human mammary epithelial cells .
19240179	0	p16INK4a	54,62	p53	0,3	p16INK4a	p53	12578(Tax:10090)	22060(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY compensatory|dobj|up-regulation leads|xcomp|compensatory leads|nsubj|Deficiency Deficiency|compound|END_ENTITY	p53 Deficiency leads to compensatory up-regulation of p16INK4a .
25961985	0	p16Ink4a	25,33	JDP2	45,49	p16Ink4a	JDP2	12578(Tax:10090)	81703(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of p16Ink4a and Arf by JDP2 in cellular senescence .
9209282	0	p16Ink4a	68,76	Tax	7,10	p16Ink4a	Tax	1029	6900	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16Ink4a and counteracts its inhibitory activity to CDK4 .
19667129	0	p16Ink4a	29,37	p53	62,65	p16Ink4a	p53	12578(Tax:10090)	22060(Tax:10090)	Gene	Gene	imaging|nmod|START_ENTITY Real-time|nmod|imaging reveals|nsubj|Real-time reveals|nmod|END_ENTITY	Real-time in vivo imaging of p16Ink4a reveals cross talk with p53 .
21912429	0	p16_INK4a	23,32	CDKN2a	64,70	p16 INK4a	CDKN2a	1029	1029	Gene	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Inverse association of p16_INK4a and p14_ARF methylation of the CDKN2a locus in different Gleason_scores_of_prostate_cancer .
18784769	0	p16_Ink4a	125,134	p19_Arf	135,142	p16 Ink4a	p19 Arf	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	NTP report on the toxicology and carcinogenesis study of benzene -LRB- CAS No. 71-43-2 -RRB- in genetically modified haploinsufficient p16_Ink4a / p19_Arf mice -LRB- gavage study -RRB- .
23826727	0	p16ink4a	82,90	PTEN	0,4	p16ink4a	PTEN	12578(Tax:10090)	19211(Tax:10090)	Gene	Gene	regulating|dobj|START_ENTITY controls|advcl|regulating controls|nsubj|END_ENTITY	PTEN controls b-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a .
12357355	0	p16ink4a	32,40	p14ARF	42,48	p16ink4a	p14ARF	1029	1029	Gene	Gene	START_ENTITY|appos|genes genes|amod|END_ENTITY	Deletion of the Ink4-locus -LRB- the p16ink4a , p14ARF and p15ink4b genes -RRB- predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92 .
23474228	0	p16ink4a	84,92	p53	150,153	p16ink4a	p53	1029	7157	Gene	Gene	penile_carcinogenesis|dep|START_ENTITY pathways|nmod|penile_carcinogenesis express|nsubj|pathways express|dobj|END_ENTITY	Two major pathways of penile_carcinogenesis : HPV-induced penile_cancers overexpress p16ink4a , HPV-negative_cancers associated with dermatoses express p53 , but lack p16ink4a overexpression .
18570590	0	p17	21,24	CD28	42,46	p17	CD28	54107	940	Gene	Gene	prevents|nsubj|START_ENTITY prevents|dobj|loss loss|nmod|expression expression|compound|END_ENTITY	HIV-1 matrix protein p17 prevents loss of CD28 expression during IL-2-induced maturation of na ve CD8 -LRB- + -RRB- T cells .
22262769	0	p17	21,24	CXCR1	52,57	p17	CXCR1	653820	3577	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation .
22904195	0	p17	21,24	CXCR1	71,76	p17	CXCR1	653820	3577	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|angiogenesis angiogenesis|nmod|END_ENTITY	HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2 .
25121556	0	p17	47,50	CXCR1	2,7	p17	CXCR1	653820	3577	Gene	Gene	activity|amod|START_ENTITY hampers|xcomp|activity hampers|nsubj|haplotype haplotype|compound|END_ENTITY	A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity .
2514776	0	p17	118,121	Interferon-gamma	0,16	p17	Interferon-gamma	653820	3458	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Interferon-gamma is associated with the surface of the human_immunodeficiency_virus and binds to the gag gene product p17 .
12763761	0	p17	4,7	caspase-3	24,33	p17	caspase-3	108900(Tax:10090)	12367(Tax:10090)	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic_plaque .
2064827	0	p17	0,3	gag	23,26	p17	gag	653820	155030(Tax:11676)	Gene	Gene	precursors|amod|START_ENTITY precursors|compound|END_ENTITY	p17 and p17-containing gag precursors of input human_immunodeficiency_virus are transported into the nuclei of infected cells .
14681224	0	p18	4,7	Bax	26,29	p18	Bax	100689229	581	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein .
19411068	0	p18	14,17	GATA3	51,56	p18	GATA3	1031	2625	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	CDK inhibitor p18 -LRB- INK4c -RRB- is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis .
12698196	0	p18	69,72	INK4A	61,66	p18	INK4A	1031	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
15349907	0	p18	43,46	INK4C	47,52	p18	INK4C	1031	1031	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of cell cycle regulator p18 -LRB- INK4C -RRB- in human hepatocellular_carcinoma .
18642058	0	p18	40,43	INK4C	45,50	p18	INK4C	1031	1031	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sodium_butyrate-induced upregulation of p18 -LRB- INK4C -RRB- gene affects K562 cell G -LRB- 0 -RRB- / G -LRB- 1 -RRB- arrest and differentiation .
26350239	6	p18	794,797	INK4C	798,803	p18	INK4C	1031	1031	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Furthermore , we found that DNMT3A modulated p18 -LRB- INK4C -RRB- by directly binding to and silencing the p18 -LRB- INK4C -RRB- gene via promoter hypermethylation .
11544316	0	p18	35,38	INK4c	39,44	p18	INK4c	12580(Tax:10090)	12580(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	An important role of CDK inhibitor p18 -LRB- INK4c -RRB- in modulating antigen receptor-mediated T cell proliferation .
18316595	0	p18	48,51	RET	32,35	p18	RET	12580(Tax:10090)	19713(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of oncogenic RET and loss of p18 on medullary_thyroid_carcinoma development .
21112821	0	p18	96,99	RET	134,137	p18	RET	1031	5979	Gene	Gene	regulation|nmod|START_ENTITY required|nmod|regulation required|nmod|END_ENTITY	N-Myc is a downstream target of RET signaling and is required for transcriptional regulation of p18 -LRB- Ink4c -RRB- by the transforming mutant RET -LRB- C634R -RRB- .
12698196	0	p18	69,72	p19	81,84	p18	p19	1031	1032	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
12698196	0	p18	69,72	p21	93,96	p18	p21	1031	1026	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
15680327	0	p18	39,42	p53	55,58	p18	p53	12580(Tax:10090)	22060(Tax:10090)	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR .
15493268	0	p180	46,50	CD6	14,17	p180	CD6	5422	923	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of CD6 and the UCHL1-defined CD45 -LRB- p180 -RRB- antigen by human colonic T lymphocytes .
21541636	0	p185	14,18	B104-1	33,39	p185	B104-1	66515(Tax:10090)	947391(Tax:511145)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Regulation of p185 expression in B104-1 cells transfected with antisense neu retrovirus vectors .
7927925	0	p185	59,63	C-erbB-2	36,44	p185	C-erbB-2	8661	2064	Gene	Gene	activity|appos|START_ENTITY activity|nmod|product product|compound|END_ENTITY	The tyrosine kinase activity of the C-erbB-2 gene product -LRB- p185 -RRB- is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin .
8600074	0	p185	173,177	C-erbB-2	155,163	p185	C-erbB-2	8661	2064	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Endometrial_adenocarcinoma of endometrioid subtype with squamous differentiation : an immunohistochemical study of MIB-1 -LRB- ki-67 paraffin -RRB- , cathepsin_D , and C-erbB-2 protein -LRB- p185 -RRB- .
10471520	0	p185	89,93	HER2/neu	40,48	p185	HER2/neu	8661	2064	Gene	Gene	amplification|nmod|START_ENTITY PCR|dep|amplification PCR|dep|analysis analysis|nmod|c-erb_B-2 c-erb_B-2|appos|END_ENTITY	Quantitative PCR analysis of c-erb_B-2 -LRB- HER2/neu -RRB- gene amplification and comparison with p185 -LRB- HER2/neu -RRB- protein expression in breast_cancer drill biopsies .
1352299	0	p185	40,44	Her2/neu	14,22	p185	Her2/neu	8661	2064	Gene	Gene	oncogene|dobj|START_ENTITY oncogene|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Her2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric_carcinoma .
12419164	0	p185	73,77	c-erbB-2	64,72	p185	c-erbB-2	66515(Tax:10090)	13866(Tax:10090)	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	Development and identification of monoclonal antibodies against c-erbB-2 p185 intracellular domain .
1350198	0	p185	43,47	c-erbB-2	22,30	p185	c-erbB-2	8661	2064	Gene	Gene	protein|amod|START_ENTITY Overexpression|dep|protein Overexpression|nmod|END_ENTITY	Overexpression of the c-erbB-2 / neu-encoded p185 protein in primary lung_cancer .
2571966	0	p185	41,45	c-erbB-2	18,26	p185	c-erbB-2	8661	2064	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|product product|amod|END_ENTITY	Expression of the c-erbB-2 gene product -LRB- p185 -RRB- at different stages of neoplastic progression in the colon .
9796989	0	p185	24,28	c-erbB-2	78,86	p185	c-erbB-2	8661	2064	Gene	Gene	density|nmod|START_ENTITY determines|nsubj|density determines|xcomp|anti-p185 anti-p185|dep|END_ENTITY	Cell surface density of p185 -LRB- c-erbB-2 -RRB- determines susceptibility to anti-p185 -LRB- c-erbB-2 -RRB- - ricin A chain -LRB- RTA -RRB- immunotoxin therapy alone and in combination with anti-p170 -LRB- EGFR -RRB- - RTA in ovarian_cancer cells .
9852307	0	p185	0,4	c-erbB-2	96,104	p185	c-erbB-2	8661	2064	Gene	Gene	overexpression|amod|START_ENTITY overexpression|dep|comparison comparison|nmod|amplification amplification|amod|END_ENTITY	p185 overexpression in 220 samples of breast_cancer undergoing primary surgery : comparison with c-erbB-2 gene amplification .
21680730	0	p185	62,66	her2/neu	67,75	p185	her2/neu	8661	2064	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structural insights into the down-regulation of overexpressed p185 -LRB- her2/neu -RRB- protein of transformed cells by the antibody chA21 .
1978329	0	p185	85,89	neu	64,67	p185	neu	8661	2064	Gene	Gene	protein|amod|START_ENTITY oncogene-encoded|dobj|protein oncogene-encoded|nsubj|Correlation Correlation|nmod|structure structure|nmod|domain domain|nmod|END_ENTITY	Correlation of the structure of the transmembrane domain of the neu oncogene-encoded p185 protein with its function .
2451200	0	p185	81,85	neu	60,63	p185	neu	66515(Tax:10090)	13866(Tax:10090)	Gene	Gene	effects|amod|START_ENTITY effects|compound|END_ENTITY	Monoclonal antibodies reactive with distinct domains of the neu oncogene-encoded p185 molecule exert synergistic anti-tumor effects in vivo .
2566965	0	p185	102,106	neu	80,83	p185	neu	8661	13866(Tax:10090)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Generation and characterization of monoclonal antibodies specific for the human neu oncogene product , p185 .
2576207	0	p185	131,135	neu	110,113	p185	neu	8661	2064	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Conformational changes induced by the transforming amino_acid substitution in the transmembrane domain of the neu oncogene-encoded p185 protein .
7913577	0	p185	34,38	p53	0,3	p185	p53	8661	7157	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	p53 protein and c-erbB-2 protein -LRB- p185 -RRB- expression in endometrial_adenocarcinoma of endometrioid type .
8617772	0	p185erbB2	0,9	GRP94	19,24	p185erbB2	GRP94	2064	7184	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	p185erbB2 binds to GRP94 in vivo .
9001419	0	p18INK4C	75,83	p15INK4B	65,73	p18INK4C	p15INK4B	1031	1030	Gene	Gene	p16INK4A|appos|START_ENTITY p16INK4A|appos|END_ENTITY	Expression and regulation of G1 cell-cycle inhibitors -LRB- p16INK4A , p15INK4B , p18INK4C , p19INK4D -RRB- in human acute_myeloid_leukemia and normal myeloid cells .
9001419	0	p18INK4C	75,83	p19INK4D	85,93	p18INK4C	p19INK4D	1031	1032	Gene	Gene	p16INK4A|appos|START_ENTITY p16INK4A|appos|END_ENTITY	Expression and regulation of G1 cell-cycle inhibitors -LRB- p16INK4A , p15INK4B , p18INK4C , p19INK4D -RRB- in human acute_myeloid_leukemia and normal myeloid cells .
8898364	0	p18INK4c	13,21	CDK4	59,63	p18INK4c	CDK4	12580(Tax:10090)	12567(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation .
18973139	0	p18INK4c	29,37	CDKN2C	21,27	p18INK4c	CDKN2C	12580(Tax:10090)	12580(Tax:10090)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Frequent loss of the CDKN2C -LRB- p18INK4c -RRB- gene product in pituitary_adenomas .
12077144	0	p18INK4c	58,66	E2F1	96,100	p18INK4c	E2F1	1031	1869	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1 .
17145768	0	p18Ink4c	0,8	Men1	45,49	p18Ink4c	Men1	12580(Tax:10090)	17283(Tax:10090)	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	p18Ink4c , but not p27Kip1 , collaborates with Men1 to suppress neuroendocrine_organ_tumors .
15711769	0	p18ink4c	41,49	Patched-2	51,60	p18ink4c	Patched-2	1031	8643	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Mutational study of the 1p located genes p18ink4c , Patched-2 , RIZ1 and KIF1B in oligodendrogliomas .
15711769	0	p18ink4c	41,49	RIZ1	62,66	p18ink4c	RIZ1	1031	7799	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Mutational study of the 1p located genes p18ink4c , Patched-2 , RIZ1 and KIF1B in oligodendrogliomas .
26138095	0	p19	12,15	H-Ras	24,29	p19	H-Ras	51561	3265	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello_syndrome cell model .
21156751	0	p19	32,35	IL-23	37,42	p19	IL-23	83430(Tax:10090)	83430(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TLR2 deficiency by compromising p19 -LRB- IL-23 -RRB- expression limits Th 17 cell responses to Mycobacterium_tuberculosis .
26189370	0	p19	87,90	IL-23	81,86	p19	IL-23	83430(Tax:10090)	83430(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Prostaglandin_E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-kB pathways .
7739547	0	p19	21,24	INK4	6,10	p19	INK4	12581(Tax:10090)	1029	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Novel INK4 proteins , p19 and p18 , are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6 .
12698196	0	p19	81,84	INK4A	61,66	p19	INK4A	1032	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
11255035	0	p19	135,138	INK4d	139,144	p19	INK4d	1032	1032	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Retroviral manipulation of the expression of bone morphogenetic protein receptor Ia by SVZa progenitor cells leads to changes in their p19 -LRB- INK4d -RRB- expression but not in their neuronal commitment .
12062451	0	p19	52,55	INK4d	56,61	p19	INK4d	1032	1032	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the human p19 -LRB- INK4d -RRB- gene promoter .
12941628	0	p19	85,88	INK4d	89,94	p19	INK4d	12581(Tax:10090)	12581(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19 -LRB- INK4d -RRB- expression during odontogenesis .
17873901	0	p19	51,54	INK4d	55,60	p19	INK4d	12581(Tax:10090)	12581(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	FOXO transcription factor-dependent p15 -LRB- INK4b -RRB- and p19 -LRB- INK4d -RRB- expression .
23536791	0	p19	45,48	Ink4d	49,54	p19	Ink4d	1032	1032	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Polypyrimidine_tract-binding_protein induces p19 -LRB- Ink4d -RRB- expression and inhibits the proliferation of H1299 cells .
23536791	0	p19	45,48	Polypyrimidine_tract-binding_protein	0,36	p19	Polypyrimidine tract-binding protein	1032	5725	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Polypyrimidine_tract-binding_protein induces p19 -LRB- Ink4d -RRB- expression and inhibits the proliferation of H1299 cells .
20840651	0	p19	28,31	SAA	52,55	p19	SAA	51561	6287	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of interleukin-23 p19 by serum_amyloid_A -LRB- SAA -RRB- in rheumatoid_synoviocytes .
6304352	0	p19	65,68	gag	76,79	p19	gag	51561	1491923(Tax:11886)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Transformation-defective Rous_sarcoma_virus mutants with altered p19 of the gag gene and their inhibitory effect on host cell growth .
24401748	0	p19	25,28	miR-34a	0,7	p19	miR-34a	83430(Tax:10090)	723848(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	miR-34a is essential for p19 -LRB- Arf -RRB- - driven cell cycle arrest .
12698196	0	p19	81,84	p18	69,72	p19	p18	1032	1031	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
12698196	0	p19	81,84	p21	93,96	p19	p21	1032	1026	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
10602422	0	p190	62,66	BCR-ABL	68,75	p190	BCR-ABL	8506	25	Gene	Gene	b3a2|appos|START_ENTITY acute_lymphoblastic_leukemia|nmod|b3a2 END_ENTITY|nsubj|acute_lymphoblastic_leukemia	Pre-B acute_lymphoblastic_leukemia with b3a2 -LRB- p210 -RRB- and e1a2 -LRB- p190 -RRB- BCR-ABL fusion transcripts relapsing as chronic_myelogenous_leukemia with a less differentiated b3a2 -LRB- p210 -RRB- clone .
10753848	0	p190	237,241	BCR-ABL	242,249	p190	BCR-ABL	8506	25	Gene	Gene	detection|amod|START_ENTITY detection|appos|END_ENTITY	Molecular analysis of lineage-specific chimerism and minimal_residual_disease by RT-PCR of p210 -LRB- BCR-ABL -RRB- and p190 -LRB- BCR-ABL -RRB- after allogeneic bone marrow transplantation for chronic_myeloid_leukemia : increasing mixed myeloid chimerism and p190 -LRB- BCR-ABL -RRB- detection precede cytogenetic relapse .
19091403	0	p190	59,63	BCR-ABL	64,71	p190	BCR-ABL	8506	25	Gene	Gene	imatinib|nmod|START_ENTITY response|nmod|imatinib END_ENTITY|nsubj|response	Molecular response to imatinib in patient with Ph negative p190 BCR-ABL transcript positive chronic_myeloid_leukemia with cyclic_leukocytosis .
25949834	0	p190	39,43	BCR-ABL	45,52	p190	BCR-ABL	8506	25	Gene	Gene	Methods|nmod|START_ENTITY Methods|appos|END_ENTITY	Optimal Molecular Methods in Detecting p190 -LRB- BCR-ABL -RRB- Fusion Variants in Hematologic_Malignancies : A Case Report and Review of the Literature .
9310467	0	p190	10,14	BCR-ABL	2,9	p190	BCR-ABL	19417(Tax:10090)	25	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	A BCR-ABL -LRB- p190 -RRB- fusion gene made by homologous recombination causes B-cell_acute_lymphoblastic_leukemias in chimeric mice with independence of the endogenous bcr product .
16078266	0	p190	45,49	Bcr-Abl	50,57	p190	Bcr-Abl	8506	25	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	AMN107 , a novel aminopyrimidine inhibitor of p190 Bcr-Abl activation and of in vitro proliferation of Philadelphia-positive acute_lymphoblastic_leukemia cells .
10586207	0	p190	0,4	bcr-abl	5,12	p190	bcr-abl	8506	25	Gene	Gene	rearrangement|amod|START_ENTITY rearrangement|amod|END_ENTITY	p190 bcr-abl rearrangement : a secondary cytogenetic event in some chronic myeloid_disorders ?
1847983	0	p190	66,70	bcr-abl	71,78	p190	bcr-abl	8506	25	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Establishment of a lymphoblastoid cell line , SD-1 , expressing the p190 bcr-abl chimaeric protein .
9360779	0	p190	121,125	bcr-abl	126,133	p190	bcr-abl	8506	25	Gene	Gene	oncogene|amod|START_ENTITY oncogene|amod|END_ENTITY	Ribozyme-mediated inhibition of a Philadelphia_chromosome-positive_acute_lymphoblastic_leukemia cell line expressing the p190 bcr-abl oncogene .
24316134	0	p190B_rhoGAP	107,119	miR-494	29,36	p190B rhoGAP	miR-494	394	574452	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Ionizing radiation-inducible miR-494 promotes glioma cell invasion through EGFR stabilization by targeting p190B_rhoGAP .
11342655	0	p190RhoGAP	8,18	RhoA	52,56	p190RhoGAP	RhoA	2909	387	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Role of p190RhoGAP in beta_2 integrin regulation of RhoA in human neutrophils .
11553710	0	p190RhoGAP	21,31	RhoA	0,4	p190RhoGAP	RhoA	2909	387	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|compound|END_ENTITY	RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity .
11058585	0	p190RhoGEF	20,30	RhoA-specific_guanine_nucleotide_exchange_factor	34,82	p190RhoGEF	RhoA-specific guanine nucleotide exchange factor	64283;9181	9826	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of p190RhoGEF , a RhoA-specific_guanine_nucleotide_exchange_factor that interacts with microtubules .
12702722	0	p190RhoGEF	49,59	focal_adhesion_kinase	22,43	p190RhoGEF	focal adhesion kinase	110596;16800	14083(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of focal_adhesion_kinase with p190RhoGEF .
17562701	0	p190_RhoGAP	24,35	Angiopoietin-1	0,14	p190 RhoGAP	Angiopoietin-1	232906(Tax:10090)	11600(Tax:10090)	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|END_ENTITY	Angiopoietin-1 requires p190_RhoGAP to protect against vascular_leakage in vivo .
11057904	0	p19ARF	84,90	mdm2	62,66	p19ARF	mdm2	1029	4193	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Opposing effects of Ras on p53 : transcriptional activation of mdm2 and induction of p19ARF .
11057904	0	p19ARF	84,90	p53	27,30	p19ARF	p53	1029	7157	Gene	Gene	activation|nmod|START_ENTITY effects|dep|activation effects|nmod|END_ENTITY	Opposing effects of Ras on p53 : transcriptional activation of mdm2 and induction of p19ARF .
24910389	0	p19Arf	41,47	E-cadherin	15,25	p19Arf	E-cadherin	1029	999	Gene	Gene	repression|nmod|START_ENTITY repression|amod|END_ENTITY	Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis .
22907756	0	p19Arf	0,6	platelet-derived_growth_factor_receptor_b	17,58	p19Arf	platelet-derived growth factor receptor b	12578(Tax:10090)	18596(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|xcomp|END_ENTITY	p19Arf represses platelet-derived_growth_factor_receptor_b by transcriptional and posttranscriptional mechanisms .
9001419	0	p19INK4D	85,93	p15INK4B	65,73	p19INK4D	p15INK4B	1032	1030	Gene	Gene	p16INK4A|appos|START_ENTITY p16INK4A|appos|END_ENTITY	Expression and regulation of G1 cell-cycle inhibitors -LRB- p16INK4A , p15INK4B , p18INK4C , p19INK4D -RRB- in human acute_myeloid_leukemia and normal myeloid cells .
9001419	0	p19INK4D	85,93	p18INK4C	75,83	p19INK4D	p18INK4C	1032	1031	Gene	Gene	p16INK4A|appos|START_ENTITY p16INK4A|appos|END_ENTITY	Expression and regulation of G1 cell-cycle inhibitors -LRB- p16INK4A , p15INK4B , p18INK4C , p19INK4D -RRB- in human acute_myeloid_leukemia and normal myeloid cells .
22476863	0	p19INK4d	13,21	E2F1	0,4	p19INK4d	E2F1	12581(Tax:10090)	13555(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	E2F1 induces p19INK4d , a protein involved in the DNA damage response , following UV irradiation .
18784769	0	p19_Arf	135,142	p16_Ink4a	125,134	p19 Arf	p16 Ink4a	12578(Tax:10090)	12578(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	NTP report on the toxicology and carcinogenesis study of benzene -LRB- CAS No. 71-43-2 -RRB- in genetically modified haploinsufficient p16_Ink4a / p19_Arf mice -LRB- gavage study -RRB- .
10364170	0	p200	53,57	sec7	38,42	p200	sec7	10565	9267	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Brefeldin_A inhibited activity of the sec7 domain of p200 , a mammalian guanine_nucleotide-exchange_protein for ADP-ribosylation_factors .
12884364	0	p202	67,71	probasin	40,48	p202	probasin	26388(Tax:10090)	54192(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prostate-specific antitumor activity by probasin promoter-directed p202 expression .
10409760	0	p20K	52,56	lipocalin	57,66	p20K	lipocalin	396393(Tax:9031)	424893(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	C/EBPbeta -LRB- NF-M -RRB- is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts .
15332997	0	p21	161,164	14-3-3sigma	137,148	p21	14-3-3sigma	1026	2810	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Computerized video time lapse study of cell cycle delay and arrest , mitotic catastrophe , apoptosis and clonogenic survival in irradiated 14-3-3sigma and CDKN1A -LRB- p21 -RRB- knockout cell lines .
15165036	0	p21	18,21	15-LOX-1	0,8	p21	15-LOX-1	1026	246	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	15-LOX-1 inhibits p21 -LRB- Cip/WAF _ 1 -RRB- expression by enhancing MEK-ERK_1 / 2 signaling in colon_carcinoma cells .
13679862	0	p21	167,170	AKT	204,207	p21	AKT	1026	207	Gene	Gene	induction|amod|START_ENTITY induction|nmod|inhibition inhibition|compound|END_ENTITY	Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21 -LRB- CIP1/WAF1 -RRB- induction rather than AKT inhibition .
16574813	0	p21	110,113	AKT	157,160	p21	AKT	1026	207	Gene	Gene	induction|nmod|START_ENTITY progression|dep|induction progression|parataxis|END_ENTITY	Ganglioside_GM3 modulates tumor suppressor PTEN-mediated cell cycle progression -- transcriptional induction of p21 -LRB- WAF1 -RRB- and p27 -LRB- kip1 -RRB- by inhibition of PI-3K / AKT pathway .
22119715	0	p21	98,101	AKT	114,117	p21	AKT	12575(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	TGF-b promotes proliferation of thyroid epithelial cells in IFN-y -LRB- - / - -RRB- mice by down-regulation of p21 and p27 via AKT pathway .
25919700	0	p21	15,18	AMP-18	0,6	p21	AMP-18	12575(Tax:10090)	66283(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Targets Targets|compound|END_ENTITY	AMP-18 Targets p21 to Maintain Epithelial Homeostasis .
25919700	0	p21	15,18	AMP-18	0,6	p21	AMP-18	12575(Tax:10090)	66283(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Targets Targets|compound|END_ENTITY	AMP-18 Targets p21 to Maintain Epithelial Homeostasis .
14978340	0	p21	127,130	ATBF1	103,108	p21	ATBF1	1026	463	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Susceptibility to killer T cells of gastric_cancer cells enhanced by Mitomycin-C involves induction of ATBF1 and activation of p21 -LRB- Waf1/Cip1 -RRB- promoter .
12782595	0	p21	40,43	ATM	65,68	p21	ATM	1026	472	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Histone deacetylase inhibitors activate p21 -LRB- WAF1 -RRB- expression via ATM .
21617849	0	p21	90,93	Akt	54,57	p21	Akt	644914	207	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Aspirin reduces the apoptotic effect of etoposide via Akt activation and up-regulation of p21 -LRB- cip -RRB- .
21671244	0	p21	110,113	Akt	17,20	p21	Akt	12575(Tax:10090)	11651(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY changing|dobj|localization regulate|advcl|changing regulate|nsubj|END_ENTITY	Protein_kinase_B / Akt may regulate G2/M transition in the fertilized mouse egg by changing the localization of p21 -LRB- Cip1/WAF1 -RRB- .
26030190	0	p21	91,94	Akt	18,21	p21	Akt	1026	207	Gene	Gene	counter-regulation|nmod|START_ENTITY enhances|nmod|counter-regulation enhances|nsubj|END_ENTITY	Nuclear localized Akt enhances breast_cancer stem-like cells through counter-regulation of p21 -LRB- Waf1/Cip1 -RRB- and p27 -LRB- kip1 -RRB- .
16982699	0	p21	85,88	Akt2	47,51	p21	Akt2	1026	208	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Only Akt1 is required for proliferation , while Akt2 promotes cell cycle exit through p21 binding .
18339845	0	p21	34,37	BAF180	0,6	p21	BAF180	1026	55193	Gene	Gene	induction|amod|START_ENTITY regulator|nmod|induction regulator|nsubj|END_ENTITY	BAF180 is a critical regulator of p21 induction and a tumor suppressor mutated in breast_cancer .
26992241	0	p21	85,88	BAF180	0,6	p21	BAF180	12575(Tax:10090)	66923(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21 .
9826721	0	p21	111,114	BAX	115,118	p21	BAX	644914	581	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 -LRB- BAX -RRB- expression .
21245169	0	p21	55,58	BRCA1	42,47	p21	BRCA1	1026	672	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation .
12433990	0	p21	84,87	Bax	125,128	p21	Bax	644914	581	Gene	Gene	promoter|amod|START_ENTITY mediate|nmod|promoter mediate|nmod|promoter promoter|compound|END_ENTITY	Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter .
17302609	0	p21	40,43	Bax	98,101	p21	Bax	644914	581	Gene	Gene	Rb|amod|START_ENTITY proteins|compound|Rb modulators|dobj|proteins modulators|dep|associated associated|nsubjpass|END_ENTITY	Downregulation of cell cycle modulators p21 , p27 , p53 , Rb and proapoptotic Bcl-2-related proteins Bax and Bak in cutaneous melanoma is associated with worse patient prognosis : preliminary findings .
10903423	0	p21	61,64	Bone_morphogenetic_protein-2	0,28	p21	Bone morphogenetic protein-2	1026	650	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Bone_morphogenetic_protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast_cancer cells .
12456965	0	p21	40,43	CD34	79,83	p21	CD34	1026	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Expansion of LTC-ICs and maintenance of p21 and BCL-2 expression in cord blood CD34 -LRB- + -RRB- / CD38 -LRB- - -RRB- early progenitors cultured over human MSCs as a feeder layer .
26645604	0	p21	74,77	CD4	42,45	p21	CD4	1026	920	Gene	Gene	Replication|nmod|START_ENTITY Replication|nmod|Cells Cells|compound|END_ENTITY	Atorvastatin Restricts HIV Replication in CD4 + T Cells by Upregulation of p21 .
26755399	0	p21	59,62	CD4	66,69	p21	CD4	1026	920	Gene	Gene	START_ENTITY|nmod|Cells Cells|compound|END_ENTITY	HIV-1 Infection Dysregulates Cell Cycle Regulatory Protein p21 in CD4 + T Cells through miR-20a and miR-106b Regulation .
7589131	0	p21	114,117	CD4	41,44	p21	CD4	12575(Tax:10090)	12504(Tax:10090)	Gene	Gene	K-ras|nummod|START_ENTITY epitopes|nmod|K-ras bearing|dobj|epitopes cells|acl|bearing lymphocytes|nmod|cells lymphocytes|nsubj|activation activation|nmod|T T|compound|END_ENTITY	Peptide-specific activation of cytolytic CD4 + T lymphocytes against tumor cells bearing mutated epitopes of K-ras p21 .
11591175	0	p21	0,3	CDK2	29,33	p21	CDK2	1026	1017	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|protein protein|compound|END_ENTITY	p21 -LRB- WAF1 -RRB- is associated with CDK2 and CDK4 protein during HL-60 cell differentiation by TPA treatment .
12706118	0	p21	109,112	CDK2	47,51	p21	CDK2	1026	1017	Gene	Gene	expression|amod|START_ENTITY reducing|dobj|expression senescing|advcl|reducing delay|advcl|senescing delay|dobj|growth_arrest growth_arrest|nmod|activity activity|compound|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
14572899	0	p21	56,59	CDK2	106,110	p21	CDK2	1026	1017	Gene	Gene	association|nmod|START_ENTITY requires|nsubj|association requires|dobj|region region|compound|END_ENTITY	The association of cyclin_A and cyclin kinase inhibitor p21 in response to gamma-irradiation requires the CDK2 binding region , but not the Cy motif .
9548727	0	p21	0,3	CDK2	18,22	p21	CDK2	12575(Tax:10090)	12566(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|compound|END_ENTITY	p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells .
9811471	0	p21	124,127	CDK2	88,92	p21	CDK2	644914	1017	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Lovastatin mediated G1_arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27 , independent of p53 .
10398121	0	p21	67,70	CDK4	83,87	p21	CDK4	1026	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
23737759	0	p21	103,106	CDK4	0,4	p21	CDK4	644914	1019	Gene	Gene	phosphorylation|amod|START_ENTITY mediated|nmod|phosphorylation CDK4/CDK2|acl|mediated central|nmod|CDK4/CDK2 central|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point .
9349504	0	p21	15,18	CDK4	31,35	p21	CDK4	1026	1019	Gene	Gene	WAF1/Cip1|amod|START_ENTITY WAF1/Cip1|appos|END_ENTITY	Involvement of p21 -LRB- WAF1/Cip1 -RRB- , CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition .
19122196	0	p21	97,100	CDKN1A	102,108	p21	CDKN1A	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 -LRB- CDKN1A -RRB- gene in response to 1alpha,25-dihydroxyvitamin _ D3 .
20126416	0	p21	57,60	CDKN1A	62,68	p21	CDKN1A	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of single nucleotide polymorphisms in the p21 -LRB- CDKN1A -RRB- gene and correlations with longevity in the Italian population .
20549306	0	p21	26,29	CDKN1A	30,36	p21	CDKN1A	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Beryllium_sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types .
22996374	0	p21	75,78	CDKN1A	68,74	p21	CDKN1A	1026	1026	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Detection and significance of human_papillomavirus , CDKN2A -LRB- p16 -RRB- and CDKN1A -LRB- p21 -RRB- expression in squamous_cell_carcinoma of the larynx .
23322738	0	p21	73,76	CDKN1A	78,84	p21	CDKN1A	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Tenovin-D3 , a novel small-molecule inhibitor of sirtuin SirT2 , increases p21 -LRB- CDKN1A -RRB- expression in a p53-independent manner .
26231713	0	p21	63,66	CDKN1A	67,73	p21	CDKN1A	1026	1026	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Assessing Cell Cycle Independent Function of the CDK Inhibitor p21 -LRB- CDKN1A -RRB- in DNA Repair .
26231713	0	p21	63,66	CDKN1A	67,73	p21	CDKN1A	1026	1026	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Assessing Cell Cycle Independent Function of the CDK Inhibitor p21 -LRB- CDKN1A -RRB- in DNA Repair .
3039284	0	p21	40,43	CEA	75,78	p21	CEA	644914	1048	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of ras p21 and carcinoembryonic antigens -LRB- CEA -RRB- in cholangiocarcinoma .
10022865	6	p21	963,966	CIP1	967,971	p21	CIP1	1026	1026	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	In agreement with this hypothesis , overexpression of p21 -LRB- CIP1 -RRB- in 293 cells , where CDK4 is bound to p16 -LRB- INK4a -RRB- , stimulates the formation of ternary cyclin D-CDK4-p21 -LRB- CIP1 -RRB- complexes .
10806303	0	p21	37,40	CIP1	41,45	p21	CIP1	1026	1026	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Growth factor-dependent induction of p21 -LRB- CIP1 -RRB- by the green tea polyphenol , epigallocatechin_gallate .
22146591	0	p21	82,85	CIP1	86,90	p21	CIP1	644914	1026	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21 -LRB- CIP1 -RRB- pathway .
21637851	0	p21	0,3	CUGBP1	74,80	p21	CUGBP1	1026	10658	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis .
10698951	0	p21	129,132	Cdc27	77,82	p21	Cdc27	644914	996	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|interaction interaction|nmod|END_ENTITY	Essential interaction between the fission_yeast DNA polymerase delta subunit Cdc27 and Pcn1 -LRB- PCNA -RRB- mediated through a C-terminal p21 -LRB- Cip1 -RRB- - like PCNA binding motif .
17371838	0	p21	52,55	Cdk2	35,39	p21	Cdk2	644914	1017	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Mdm2 is required for inhibition of Cdk2 activity by p21 , thereby contributing to p53-dependent cell cycle arrest .
17942597	0	p21	0,3	Cdk2	36,40	p21	Cdk2	12575(Tax:10090)	12566(Tax:10090)	Gene	Gene	Inhibits|amod|START_ENTITY Cdk1|nsubj|Inhibits Cdk1|nmod|absence absence|nmod|END_ENTITY	p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint .
21325496	0	p21	34,37	Cdk2	60,64	p21	Cdk2	1026	1017	Gene	Gene	phosphorylation|nmod|START_ENTITY regulates|nsubj|phosphorylation regulates|dobj|role role|nmod|END_ENTITY	Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity .
10713676	0	p21	32,35	Cdk4	86,90	p21	Cdk4	644914	1019	Gene	Gene	formation|amod|START_ENTITY initiates|dep|formation initiates|nmod|END_ENTITY	Survivin initiates procaspase_3 / p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death .
11790141	0	p21	22,25	Cdk4	69,73	p21	Cdk4	1026	1019	Gene	Gene	structure|nmod|START_ENTITY C-terminal|nsubj|structure C-terminal|dobj|domain domain|acl|bound bound|nmod|END_ENTITY	Solution structure of p21 -LRB- Waf1/Cip1/Sdi1 -RRB- C-terminal domain bound to Cdk4 .
15735718	0	p21	13,16	Cdk4	59,63	p21	Cdk4	644914	1019	Gene	Gene	Induction|nmod|START_ENTITY inhibits|nsubj|Induction inhibits|dobj|END_ENTITY	Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities .
25483089	0	p21	81,84	Cdt1	92,96	p21	Cdt1	1026	81620	Gene	Gene	CDK|dep|START_ENTITY Expression|appos|CDK Expression|appos|END_ENTITY	Expression of the p12 subunit of human DNA polymerase -LRB- Pol -RRB- , CDK inhibitor p21 -LRB- WAF1 -RRB- , Cdt1 , cyclin_A , PCNA and Ki-67 in relation to DNA replication in individual cells .
11369699	0	p21	83,86	Cip1	87,91	p21	Cip1	24525(Tax:10116)	114851(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21 -LRB- Cip1 -RRB- gene into the joints .
11704859	0	p21	20,23	Cip1	24,28	p21	Cip1	644914	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of p16 and p21 -LRB- Cip1 -RRB- expression in tumorigenic human bronchial epithelial cells induced by asbestos .
12773551	0	p21	78,81	Cip1	82,86	p21	Cip1	644914	1026	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21 -LRB- Cip1 -RRB- promoter .
19414386	0	p21	24,27	Cip1	35,39	p21	Cip1	1026	1026	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	G2-phase arrest through p21 -LRB- WAF1 / Cip1 -RRB- induction and cdc2 repression by gnidimacrin in human hepatoma HLE cells .
22117196	0	p21	112,115	Cip1	116,120	p21	Cip1	644914	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21 -LRB- Cip1 -RRB- expression and hampers tumour cell growth in vitro and in vivo .
9593712	0	p21	15,18	Cip1	19,23	p21	Cip1	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	GATA-6 induces p21 -LRB- Cip1 -RRB- expression and G1 cell cycle arrest .
23786849	0	p21	26,29	Cyclin_D1	0,9	p21	Cyclin D1	644914	595	Gene	Gene	invasion|amod|START_ENTITY cooperates|nmod|invasion cooperates|nsubj|END_ENTITY	Cyclin_D1 cooperates with p21 to regulate TGFb-mediated breast_cancer_cell_migration_and_tumor local invasion .
27039754	0	p21	16,19	Cyclin_D1	5,14	p21	Cyclin D1	1026	595	Gene	Gene	p53|appos|START_ENTITY p53|appos|END_ENTITY	p53 , Cyclin_D1 , p21 -LRB- WAF1 -RRB- and Ki-67 -LRB- MIB1 -RRB- Expression at Invasive Tumour Fronts of Oral_Squamous_Cell_Carcinomas and Development of Local Recurrence .
19572978	0	p21	15,18	DIXDC1	0,6	p21	DIXDC1	644914	85458	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	DIXDC1 targets p21 and cyclin_D1 via PI3K pathway activation to promote colon_cancer cell proliferation .
19275888	0	p21	0,3	DNMT1	31,36	p21	DNMT1	1026	1786	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nummod|END_ENTITY	p21 -LRB- WAF1 -RRB- negatively regulates DNMT1 expression in mammalian cells .
21572256	0	p21	31,34	EAPP	0,4	p21	EAPP	644914	55837	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	EAPP modulates the activity of p21 and Chk2 .
9705360	0	p21	80,83	ERK2	57,61	p21	ERK2	1026	5594	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21 -LRB- cip1 -RRB- .
16998811	0	p21	83,86	EZH2	49,53	p21	EZH2	1026	2146	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
25893733	0	p21	73,76	Ets-1	67,72	p21	Ets-1	644914	2113	Gene	Gene	START_ENTITY|dep|apoptosis apoptosis|nmod|END_ENTITY	MicroRNA-221 / 222 regulate ox-LDL-induced endothelial apoptosis via Ets-1 / p21 inhibition .
23375502	0	p21	109,112	FMN2	50,54	p21	FMN2	1026	56776	Gene	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|characterization characterization|nmod|END_ENTITY	Identification and functional characterization of FMN2 , a regulator of the cyclin-dependent kinase inhibitor p21 .
23839046	0	p21	67,70	FMN2	0,4	p21	FMN2	644914	56776	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	FMN2 is a novel regulator of the cyclin-dependent kinase inhibitor p21 .
17487408	0	p21	15,18	GADD34	0,6	p21	GADD34	24525(Tax:10116)	171071(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	GADD34 induces p21 expression and cellular senescence .
2574500	0	p21	76,79	GAP	107,110	p21	GAP	644914	29127	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Chromosome localization and cDNA sequence of murine and human genes for ras p21 GTPase activating protein -LRB- GAP -RRB- .
2842690	0	p21	61,64	GAP	18,21	p21	GAP	338049(Tax:9913)	282032(Tax:9913)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of bovine GAP and its interaction with oncogenic ras p21 .
20495378	0	p21	26,29	GATA-1	0,6	p21	GATA-1	1026	2623	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	GATA-1 directly regulates p21 gene expression during erythroid differentiation .
9593712	0	p21	15,18	GATA-6	0,6	p21	GATA-6	12575(Tax:10090)	14465(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	GATA-6 induces p21 -LRB- Cip1 -RRB- expression and G1 cell cycle arrest .
2504724	0	p21	23,26	GTP-binding_protein	43,62	p21	GTP-binding protein	1026	8843	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|amod|END_ENTITY	Phosphorylation of smg p21 , a ras p21-like GTP-binding_protein , by cyclic_AMP-dependent protein kinase in a cell-free system and in response to prostaglandin_E1 in intact human platelets .
2849942	0	p21	110,113	GTP-binding_protein	85,104	p21	GTP-binding protein	644914	8843	Gene	Gene	smg|nummod|START_ENTITY END_ENTITY|appos|smg	Phosphorylation by cyclic_AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding_protein -LRB- smg p21 -RRB- having the same putative effector domain as the ras gene products .
20018861	0	p21	23,26	GTSE-1	6,12	p21	GTSE-1	1026	51512	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Human GTSE-1 regulates p21 -LRB- CIP1/WAF1 -RRB- stability conferring resistance to paclitaxel treatment .
23751077	0	p21	81,84	Gadd45g	0,7	p21	Gadd45g	644914	10912	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression .
23160381	0	p21	21,24	Galectin-3	0,10	p21	Galectin-3	1026	3958	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Galectin-3 regulates p21 stability in human prostate_cancer cells .
7734422	0	p21	33,36	H-Ras	27,32	p21	H-Ras	12575(Tax:10090)	15461(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Mutations in residue 61 of H-Ras p21 protein influence MHC class II presentation .
11238813	0	p21	35,38	H-ras	39,44	p21	H-ras	12575(Tax:10090)	15461(Tax:10090)	Gene	Gene	processing|compound|START_ENTITY processing|appos|END_ENTITY	Impact of garlic organosulfides on p21 -LRB- H-ras -RRB- processing .
2039838	0	p21	27,30	H-ras	4,9	p21	H-ras	644914	3265	Gene	Gene	product|dep|START_ENTITY product|compound|END_ENTITY	The H-ras oncogene product p21 and prognosis in human breast_cancer .
2199064	0	p21	38,41	H-ras	32,37	p21	H-ras	644914	3265	Gene	Gene	mutants|amod|START_ENTITY mutants|compound|END_ENTITY	Three-dimensional structures of H-ras p21 mutants : molecular basis for their inability to function as signal switch molecules .
2405906	0	p21	61,64	H-ras	55,60	p21	H-ras	644914	3265	Gene	Gene	mutants|amod|START_ENTITY mutants|compound|END_ENTITY	Proton NMR studies of transforming and nontransforming H-ras p21 mutants .
6089191	0	p21	104,107	H-ras	38,43	p21	H-ras	644914	3265	Gene	Gene	proteins|amod|START_ENTITY Expression|nmod|proteins Expression|nmod|genes genes|compound|END_ENTITY	Expression of normal and transforming H-ras genes in Escherichia_coli and purification of their encoded p21 proteins .
8129867	0	p21	45,48	H-ras	26,31	p21	H-ras	644914	3265	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Molecular dynamics of the H-ras gene-encoded p21 protein ; identification of flexible regions and possible effector domains .
17671089	0	p21	0,3	H2A.Z	71,76	p21	H2A.Z	644914	3015	Gene	Gene	transcription|amod|START_ENTITY regulated|nsubjpass|transcription regulated|nmod|localization localization|nmod|END_ENTITY	p21 transcription is regulated by differential localization of histone H2A.Z .
23146670	0	p21	61,64	H2A.Z	44,49	p21	H2A.Z	644914	3015	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Decrease of p400 ATPase complex and loss of H2A.Z within the p21 promoter occur in senescent IMR-90 human fibroblasts .
23349794	0	p21	14,17	H2A.Z	61,66	p21	H2A.Z	644914	3015	Gene	Gene	Activation|nmod|START_ENTITY requires|nsubj|Activation requires|dobj|acetylation acetylation|nmod|END_ENTITY	Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z .
18850004	0	p21	16,19	HDAC4	0,5	p21	HDAC4	1026	9759	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	HDAC4 represses p21 -LRB- WAF1/Cip1 -RRB- expression in human cancer cells through a Sp1-dependent , p53-independent mechanism .
18166158	0	p21	64,67	HIF-1alpha	0,10	p21	HIF-1alpha	1026	3091	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	HIF-1alpha controls keratinocyte proliferation by up-regulating p21 -LRB- WAF1/Cip1 -RRB- .
11040212	0	p21	0,3	HOXA10	35,41	p21	HOXA10	1026	3206	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells .
6611509	0	p21	60,63	Ha-ras	53,59	p21	Ha-ras	12575(Tax:10090)	15461(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein .
8876671	0	p21	164,167	Ha-ras	157,163	p21	Ha-ras	12575(Tax:10090)	15461(Tax:10090)	Gene	Gene	localization|amod|START_ENTITY localization|compound|END_ENTITY	Protection against malignant conversion in SENCAR mouse skin by all trans retinoic_acid : inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization .
12038984	0	p21	34,37	Hsp25	0,5	p21	Hsp25	12575(Tax:10090)	15507(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hsp25 regulates the expression of p21 -LRB- Waf1/Cip1/Sdi1 -RRB- through multiple mechanisms .
22698403	0	p21	94,97	ID1	0,3	p21	ID1	644914	3397	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	ID1 and ID3 regulate the self-renewal capacity of human colon_cancer-initiating cells through p21 .
10638704	0	p21	23,26	IFN-gamma	0,9	p21	IFN-gamma	1026	3458	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	IFN-gamma induction of p21 -LRB- WAF1 -RRB- is required for cell cycle inhibition and suppression of apoptosis .
9121765	0	p21	73,76	IFNalpha	0,8	p21	IFNalpha	1026	3439	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IFNalpha induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate_cancer cells .
22392074	0	p21	18,21	IGFBP-rP1	0,9	p21	IGFBP-rP1	1026	3490	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IGFBP-rP1 induces p21 expression through a p53-independent pathway , leading to cellular senescence of MCF-7 breast_cancer cells .
10788799	0	p21	27,30	IL-1	0,4	p21	IL-1	1026	3553	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-1 induces expression of p21 -LRB- WAF1 -RRB- independently of p53 in high-passage human embryonic fibroblasts WI38 .
12517948	0	p21	91,94	IL-6_and_matrix_metalloproteinase-1	0,35	p21	IL-6 and matrix metalloproteinase-1	12575(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	IL-6_and_matrix_metalloproteinase-1 are regulated by the cyclin-dependent kinase inhibitor p21 in synovial fibroblasts .
11102889	0	p21	101,104	INK4A	93,98	p21	INK4A	1026	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
12698196	0	p21	93,96	INK4A	61,66	p21	INK4A	1026	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
16998811	0	p21	83,86	INK4A	64,69	p21	INK4A	1026	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
15067513	0	p21	39,42	Insulin-like_growth_factor-I	0,28	p21	Insulin-like growth factor-I	24525(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Insulin-like_growth_factor-I increases p21 expression and attenuates cisplatin-induced acute renal_injury in rats .
22200613	0	p21	47,50	Interferon_Regulatory_Factor_1	0,30	p21	Interferon Regulatory Factor 1	1026	3659	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interferon_Regulatory_Factor_1 -LRB- IRF-1 -RRB- induces p21 -LRB- WAF1/CIP1 -RRB- dependent cell cycle arrest and p21 -LRB- WAF1/CIP1 -RRB- independent modulation of survivin in cancer cells .
25331946	0	p21	75,78	JAZ	0,3	p21	JAZ	1026	23567	Gene	Gene	Protects|nmod|START_ENTITY Protects|nsubj|END_ENTITY	JAZ -LRB- Znf346 -RRB- , a SIRT1-interacting Protein , Protects Neurons by Stimulating p21 -LRB- WAF/CIP1 -RRB- Protein Expression .
11195463	0	p21	6,9	K-ras	0,5	p21	K-ras	12575(Tax:10090)	16653(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	K-ras p21 expression and activity in lung and lung_tumors .
3553214	0	p21	6,9	Ki-RAS	10,16	p21	Ki-RAS	24525(Tax:10116)	24525(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Viral p21 Ki-RAS protein : a potent intracellular mitogen that stimulates adenylate cyclase activity in early G1 phase of cultured rat cells .
12014640	0	p21	22,25	Ki-ras	26,32	p21	Ki-ras	24525(Tax:10116)	24525(Tax:10116)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Expression of p53 and p21 Ki-ras proteins in rat thyroid gland tumors induced by 3-chloro-4 - -LRB- dichloromethyl -RRB- -5 - hydroxy-2 -LRB- 5H -RRB- - furanone -LRB- MX -RRB- .
9364215	0	p21	22,25	Ki-ras	15,21	p21	Ki-ras	644914	3845	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Suppression of Ki-ras p21 levels leading to growth inhibition of pancreatic_cancer cell lines with Ki-ras mutation but not those without Ki-ras mutation .
12393444	0	p21	116,119	Kip1	134,138	p21	Kip1	12575(Tax:10090)	12576(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	GATA-2 / estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21 -LRB- WAF1 -RRB- and p27 -LRB- Kip1 -RRB- proteins .
16580634	0	p21	34,37	LKB1	21,25	p21	LKB1	644914	6794	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4 , GATA-6 , and Ldb1 .
16580634	0	p21	34,37	LMO4	71,75	p21	LMO4	644914	8543	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4 , GATA-6 , and Ldb1 .
10329038	0	p21	70,73	MDM2	64,68	p21	MDM2	1026	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	p21	67,70	MDM2	93,97	p21	MDM2	1026	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
10490460	0	p21	48,51	MDM2	19,23	p21	MDM2	12575(Tax:10090)	17246(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|nmod|protein protein|nummod|END_ENTITY	High expression of MDM2 protein and low rate of p21 -LRB- WAF1/CIP1 -RRB- expression in SCID mice Epstein_Barr_virus-induced lymphoproliferation .
19428175	0	p21	55,58	MDM2	29,33	p21	MDM2	1026	4193	Gene	Gene	expression|amod|START_ENTITY oncogene|dobj|expression oncogene|nsubj|END_ENTITY	Gambogic_acid down-regulates MDM2 oncogene and induces p21 -LRB- Waf1/CIP1 -RRB- expression independent of p53 .
25888165	0	p21	45,48	MKL1	0,4	p21	MKL1	12575(Tax:10090)	223701(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MKL1 inhibits cell cycle progression through p21 in podocytes .
25888165	0	p21	45,48	MKL1	0,4	p21	MKL1	12575(Tax:10090)	223701(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	MKL1 inhibits cell cycle progression through p21 in podocytes .
12080472	0	p21	56,59	Mdm2	0,4	p21	Mdm2	12575(Tax:10090)	17246(Tax:10090)	Gene	Gene	transactivation|nmod|START_ENTITY induces|dobj|transactivation induces|nsubj|inhibition inhibition|amod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
17371838	0	p21	52,55	Mdm2	0,4	p21	Mdm2	644914	4193	Gene	Gene	activity|nmod|START_ENTITY inhibition|nmod|activity required|nmod|inhibition required|nsubjpass|END_ENTITY	Mdm2 is required for inhibition of Cdk2 activity by p21 , thereby contributing to p53-dependent cell cycle arrest .
17536310	0	p21	31,34	Mdm2	25,29	p21	Mdm2	1026	4193	Gene	Gene	Bcl-2|amod|START_ENTITY Immunoreactivity|appos|Bcl-2 Immunoreactivity|appos|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
18485798	0	p21	11,14	Mdm2	0,4	p21	Mdm2	644914	4193	Gene	Gene	pathways|nsubj|START_ENTITY pathways|advmod|END_ENTITY	Mdm2 , p53 , p21 and pAKT protein pathways in benign neoplasms of the salivary gland .
1844332	0	p21	47,50	N-ras	112,117	p21	N-ras	644914	4893	Gene	Gene	protein|amod|START_ENTITY localization|nmod|protein localization|nmod|lines lines|nmod|expression expression|compound|END_ENTITY	Immunoelectron microscopic localization of the p21 protein in HT1080 human fibrosarcoma cell lines with altered N-ras gene expression .
1844338	0	p21	47,50	N-ras	112,117	p21	N-ras	644914	4893	Gene	Gene	protein|amod|START_ENTITY localization|nmod|protein localization|nmod|lines lines|nmod|expression expression|compound|END_ENTITY	Immunoelectron microscopic localization of the p21 protein in HT1080 human fibrosarcoma cell lines with altered N-ras gene expression .
3550423	0	p21	57,60	N-ras	51,56	p21	N-ras	644914	4893	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Biochemical and biological properties of the human N-ras p21 protein .
6667677	0	p21	62,65	N-ras	26,31	p21	N-ras	644914	4893	Gene	Gene	Localisation|dep|START_ENTITY Localisation|nmod|oncogene oncogene|compound|END_ENTITY	Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation .
8208513	0	p21	43,46	N-ras	110,115	p21	N-ras	644914	4893	Gene	Gene	proteins|amod|START_ENTITY Inhibition|nmod|proteins Inhibition|nmod|cells cells|acl|possessing possessing|dobj|gene gene|compound|END_ENTITY	Inhibition of the membrane localization of p21 ras proteins by lovastatin in tumor cells possessing a mutated N-ras gene .
24568526	0	p21	114,117	NDR1/2	78,84	p21	NDR1/2	1026	11329;23012	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	Asiatic_acid promotes p21 -LRB- WAF1/CIP1 -RRB- protein stability through attenuation of NDR1/2 dependent phosphorylation of p21 -LRB- WAF1 / CIP1 -RRB- in HepG2 human hepatoma cells .
11514734	0	p21	44,47	NS3	75,78	p21	NS3	12575(Tax:10090)	3845	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	p53-dependent transcriptional repression of p21 -LRB- waf1 -RRB- by hepatitis_C_virus NS3 .
15464245	0	p21	20,23	Ninjurin1	0,9	p21	Ninjurin1	1026	4814	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells .
12781424	0	p21	81,84	P53	0,3	p21	P53	1026	7157	Gene	Gene	expression|nmod|START_ENTITY alter|nmod|expression polymorphisms|xcomp|alter polymorphisms|nsubj|END_ENTITY	P53 -LRB- codon 72 -RRB- and P21 -LRB- codon 31 -RRB- polymorphisms alter in vivo mRNA expression of p21 .
20817677	0	p21	38,41	PCBP4	78,83	p21	PCBP4	12575(Tax:10090)	59092(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability .
12854173	0	p21	26,29	PCNA	15,19	p21	PCNA	1026	5111	Gene	Gene	Expressions|appos|START_ENTITY Expressions|nmod|END_ENTITY	Expressions of PCNA , p53 , p21 -LRB- WAF-1 -RRB- and cell proliferation in fetal esophageal epithelia : comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal_cancer in Henan , _ North_China .
16491347	0	p21	92,95	PCNA	55,59	p21	PCNA	1026	5111	Gene	Gene	inhibitors|dep|START_ENTITY Ki67|amod|inhibitors Ki67|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
19572978	0	p21	15,18	PI3K	37,41	p21	PI3K	644914	5293	Gene	Gene	START_ENTITY|nmod|activation activation|nummod|END_ENTITY	DIXDC1 targets p21 and cyclin_D1 via PI3K pathway activation to promote colon_cancer cell proliferation .
12007403	0	p21	13,16	PKD1	0,4	p21	PKD1	12575(Tax:10090)	18763(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	PKD1 induces p21 -LRB- waf1 -RRB- and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2 .
25590690	0	p21	16,19	PPM1D	0,5	p21	PPM1D	1026	612934(Tax:9615)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PPM1D regulates p21 expression via dephoshporylation at serine 123 .
9363658	0	p21	0,3	Pic1	20,24	p21	Pic1	1026	7341	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	p21 -LRB- WAF1/Cip1/Sdi1 / Pic1 -RRB- mRNA is expressed in neuroblastoma cell lines but not in Ewing 's _ sarcoma and primitive_neuroectodermal_tumor cell lines .
20307683	0	p21	25,28	Pim-2	0,5	p21	Pim-2	1026	11040	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Pim-2 phosphorylation of p21 -LRB- Cip1/WAF1 -RRB- enhances its stability and inhibits cell proliferation in HCT116 cells .
20816801	0	p21	104,107	Pitx2	84,89	p21	Pitx2	12575(Tax:10090)	18741(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21 .
23131154	0	p21	26,29	Pitx2	0,5	p21	Pitx2	1026	5308	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|expression expression|amod|END_ENTITY	Pitx2 expression promotes p21 expression and cell cycle exit in neural stem cells .
23217280	0	p21	33,36	Polysaccharide-K	0,16	p21	Polysaccharide-K	1026	9344	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Polysaccharide-K -LRB- PSK -RRB- increases p21 -LRB- WAF/Cip1 -RRB- and promotes apoptosis in pancreatic_cancer cells .
7498475	0	p21	42,45	RGL	51,54	p21	RGL	1026	23179	Gene	Gene	interaction|nmod|START_ENTITY regulates|dobj|interaction regulates|nmod|END_ENTITY	rap1_p21 regulates the interaction of ras p21 with RGL , a new effector protein of ras p21 .
7498475	0	p21	86,89	RGL	51,54	p21	RGL	1026	23179	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	rap1_p21 regulates the interaction of ras p21 with RGL , a new effector protein of ras p21 .
23026136	0	p21	96,99	RNF126	20,26	p21	RNF126	644914	55658	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation .
24356969	0	p21	61,64	Rbm24	0,5	p21	Rbm24	644914	221662	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rbm24 , an RNA-binding protein and a target of p53 , regulates p21 expression via mRNA stability .
8846917	0	p21	91,94	SDI-1	108,113	p21	SDI-1	1026	1026	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	CCAAT/enhancer-binding protein alpha -LRB- C/EBP _ alpha -RRB- inhibits cell proliferation through the p21 -LRB- WAF-1 / CIP-1 / SDI-1 -RRB- protein .
25578559	0	p21	48,51	SEI-1	42,47	p21	SEI-1	12575(Tax:10090)	55942(Tax:10090)	Gene	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	KLF10 affects pancreatic function via the SEI-1 / p21 -LRB- Cip1 -RRB- pathway .
18793717	0	p21	16,19	SOCS3	0,5	p21	SOCS3	1026	9021	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage .
10656459	0	p21	41,44	SPEC-2	100,106	p21	SPEC-2	644914	56990	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Adenovirus-mediated expression of p53 or p21 in a papillary_serous_endometrial_carcinoma cell line -LRB- SPEC-2 -RRB- results in both growth inhibition and apoptotic cell death : potential application of gene therapy to endometrial_cancer .
21402054	0	p21	8,11	Sdi1	12,16	p21	Sdi1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Loss of p21 -LRB- Sdi1 -RRB- expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21 -LRB- Sdi1 -RRB- gene promoter .
15555546	0	p21	16,19	Snail	0,5	p21	Snail	1026	6615	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Snail regulates p21 -LRB- WAF/CIP1 -RRB- expression in cooperation with E2A_and_Twist .
10212208	0	p21	59,62	Sp1	116,119	p21	Sp1	1026	6667	Gene	Gene	promoter|amod|START_ENTITY activates|dobj|promoter activates|nmod|element element|acl|containing containing|dobj|sites sites|compound|END_ENTITY	The mycotoxin fumonisin_B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites .
10506225	0	p21	47,50	Sp1	136,139	p21	Sp1	1026	6667	Gene	Gene	gene|amod|START_ENTITY promoter|nmod|gene transactivates|dobj|promoter transactivates|advcl|acting acting|nmod|superactivator superactivator|nmod|END_ENTITY	c-Jun transactivates the promoter of the human p21 -LRB- WAF1/Cip1 -RRB- gene by acting as a superactivator of the ubiquitous transcription factor Sp1 .
10625687	0	p21	38,41	Sp1	23,26	p21	Sp1	1026	6667	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	p300 collaborates with Sp1 and Sp3 in p21 -LRB- waf1/cip1 -RRB- promoter activation induced by histone deacetylase inhibitor .
10733944	0	p21	30,33	Sp1	74,77	p21	Sp1	1026	6667	Gene	Gene	repression|nmod|START_ENTITY gene|nsubj|repression gene|nmod|site site|amod|END_ENTITY	Transcriptional repression of p21 -LRB- -LRB- Waf1/Cip1/Sdi1 -RRB- -RRB- gene by c-jun through Sp1 site .
10809237	0	p21	56,59	Sp1	117,120	p21	Sp1	1026	6667	Gene	Gene	gene|amod|START_ENTITY inhibitor|dobj|gene inhibitor|parataxis|complex complex|dep|role role|nmod|END_ENTITY	Androgen induction of cyclin-dependent kinase inhibitor p21 gene : role of androgen_receptor and transcription factor Sp1 complex .
11064455	0	p21	21,24	Sp1	0,3	p21	Sp1	1026	6667	Gene	Gene	gene|amod|START_ENTITY activate|dobj|gene activate|nsubj|END_ENTITY	Sp1 and Sp3 activate p21 -LRB- WAF1/CIP1 -RRB- gene transcription in the Caco-2 colon_adenocarcinoma cell line .
11384995	0	p21	107,110	Sp1	0,3	p21	Sp1	1026	6667	Gene	Gene	gene|amod|START_ENTITY inhibitor|dobj|gene plays|ccomp|inhibitor plays|nsubj|END_ENTITY	Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by the p53 tumor suppressor protein .
11551946	0	p21	14,17	Sp1	51,54	p21	Sp1	1026	6667	Gene	Gene	WAF1/Cip1|amod|START_ENTITY WAF1/Cip1|acl|transcription transcription|nmod|sites sites|amod|END_ENTITY	Activation of p21 -LRB- WAF1/Cip1 -RRB- transcription through Sp1 sites by histone deacetylase inhibitor apicidin : involvement of protein_kinase_C .
11842244	0	p21	83,86	Sp1	128,131	p21	Sp1	1026	6667	Gene	Gene	promoter|amod|START_ENTITY activates|dobj|promoter activates|nmod|END_ENTITY	The hinge region of the human papillomavirus type 8 E2_protein activates the human p21 -LRB- WAF1/CIP1 -RRB- promoter via interaction with Sp1 .
12955081	0	p21	14,17	Sp1	37,40	p21	Sp1	1026	6667	Gene	Gene	WAF1/Cip1|amod|START_ENTITY WAF1/Cip1|nmod|sites sites|amod|END_ENTITY	Expression of p21 -LRB- WAF1/Cip1 -RRB- through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC_epsilon signaling pathway .
14744793	0	p21	157,160	Sp1	184,187	p21	Sp1	1026	6667	Gene	Gene	promoter|amod|START_ENTITY transactivation|nmod|promoter kinase|nmod|transactivation kinase|nmod|END_ENTITY	Transcriptional activation of p21 -LRB- waf1/cip1 -RRB- by alkylphospholipids : role of the mitogen-activated protein kinase pathway in the transactivation of the human p21 -LRB- waf1/cip1 -RRB- promoter by Sp1 .
15094066	0	p21	66,69	Sp1	0,3	p21	Sp1	1026	6667	Gene	Gene	Waf1|amod|START_ENTITY involved|nmod|Waf1 involved|nsubjpass|END_ENTITY	Sp1 is involved in the transcriptional activation of p16 -LRB- INK4 -RRB- by p21 -LRB- Waf1 -RRB- in HeLa cells .
15345676	0	p21	73,76	Sp1	121,124	p21	Sp1	644914	6667	Gene	Gene	activation|nmod|START_ENTITY involves|nsubj|activation involves|dobj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma-dependent activation of p21 in Panc-28 pancreatic_cancer cells involves Sp1 and Sp4 proteins .
15389873	0	p21	215,218	Sp1	117,120	p21	Sp1	1026	6667	Gene	Gene	promoter|amod|START_ENTITY mediated|nmod|promoter mediated|nsubjpass|muscle muscle|acl:relcl|transcription transcription|nmod|END_ENTITY	Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21 -LRB- WAF1/Cip1 -RRB- promoter .
15389873	0	p21	85,88	Sp1	117,120	p21	Sp1	1026	6667	Gene	Gene	regulation|nmod|START_ENTITY transcription|nsubj|regulation transcription|nmod|END_ENTITY	Vascular smooth muscle cell-specific regulation of cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- transcription by Sp1 is mediated via distinct cis-acting positive and negative regulatory elements in the proximal p21 -LRB- WAF1/Cip1 -RRB- promoter .
15659839	0	p21	73,76	Sp1	0,3	p21	Sp1	1026	6667	Gene	Gene	promoters|amod|START_ENTITY regulation|nmod|promoters activity|nmod|regulation transcription|dobj|activity transcription|nsubj|END_ENTITY	Sp1 and NF-kappaB transcription factor activity in the regulation of the p21 and FasL promoters during promyelocytic_leukemia cell monocytic differentiation and its associated apoptosis .
23184467	0	p21	106,109	Sp1	22,25	p21	Sp1	1026	6667	Gene	Gene	expression|nmod|START_ENTITY modulating|dobj|expression cooperates|advcl|modulating cooperates|nmod|END_ENTITY	Stat6 cooperates with Sp1 in controlling breast_cancer cell proliferation by modulating the expression of p21 -LRB- Cip1/WAF1 -RRB- and p27 -LRB- Kip1 -RRB- .
25595558	0	p21	34,37	Sp1	0,3	p21	Sp1	644914	6667	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Sp1 regulates Raf/MEK/ERK-induced p21 -LRB- CIP1 -RRB- transcription in TP53-mutated cancer cells .
9553133	0	p21	44,47	Sp1	102,105	p21	Sp1	1026	6667	Gene	Gene	cyclin|amod|START_ENTITY transcription|nmod|cyclin transcription|dep|gene gene|nmod|END_ENTITY	Progesterone regulates transcription of the p21 -LRB- WAF1 -RRB- cyclin - dependent kinase inhibitor gene through Sp1 and CBP/p300 .
22119715	0	p21	98,101	TGF-b	0,5	p21	TGF-b	12575(Tax:10090)	21803(Tax:10090)	Gene	Gene	down-regulation|nmod|START_ENTITY promotes|nmod|down-regulation promotes|nsubj|END_ENTITY	TGF-b promotes proliferation of thyroid epithelial cells in IFN-y -LRB- - / - -RRB- mice by down-regulation of p21 and p27 via AKT pathway .
12185267	0	p21	45,48	TGF-beta	82,90	p21	TGF-beta	644914	7040	Gene	Gene	promoter|amod|START_ENTITY represses|dobj|promoter represses|nmod|inhibition inhibition|nmod|pathway pathway|amod|END_ENTITY	Hepatitis_C virus core protein represses the p21 promoter through inhibition of a TGF-beta pathway .
14726675	0	p21	0,3	TGF-beta	47,55	p21	TGF-beta	1026	7040	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- mediates the growth response to TGF-beta in human epithelial cells .
18210215	0	p21	47,50	TGIF	19,23	p21	TGIF	1026	7050	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Inhibitory role of TGIF in the As2O3-regulated p21 WAF1/CIP1 expression .
11097743	0	p21	18,21	TNF-alpha	0,9	p21	TNF-alpha	1026	7124	Gene	Gene	induced|dobj|START_ENTITY END_ENTITY|acl|induced	TNF-alpha induced p21 -LRB- WAF1 -RRB- but not Bax in colon_cancer cells WiDr with mutated p53 : important role of protein stabilization .
10329038	0	p21	70,73	TP53	58,62	p21	TP53	1026	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	p21	67,70	TP53	0,4	p21	TP53	1026	7157	Gene	Gene	proteins|nummod|START_ENTITY cycle-associated|xcomp|proteins cell|acl|cycle-associated alterations|nmod|cell alterations|nsubj|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
12243811	0	p21	53,56	TP53	20,24	p21	TP53	644914	7157	Gene	Gene	value|nmod|START_ENTITY value|nmod|activity activity|compound|END_ENTITY	Prognostic value of TP53 transcriptional activity on p21 and bax in patients with esophageal_squamous_cell_carcinomas treated by definitive chemoradiotherapy .
15161352	0	p21	59,62	TP53	42,46	p21	TP53	1026	7157	Gene	Gene	Accumulation|appos|START_ENTITY Accumulation|nmod|END_ENTITY	Accumulation of the cell cycle regulators TP53 and CDKN1A -LRB- p21 -RRB- in human fibroblasts after exposure to low - and high-LET radiation .
20966084	0	p21	83,86	TP53	77,81	p21	TP53	1026	7157	Gene	Gene	CDKN1A|amod|START_ENTITY END_ENTITY|dep|CDKN1A	DNA damage , DNA repair rates and mRNA expression levels of cell cycle genes -LRB- TP53 , p21 -LRB- CDKN1A -RRB- , BCL2_and_BAX -RRB- with respect to occupational exposure to styrene .
9010231	0	p21	0,3	TP53	57,61	p21	TP53	1026	7157	Gene	Gene	response|amod|START_ENTITY response|nmod|agents agents|nmod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- response to genotoxic agents in wild-type TP53 expressing breast primary tumours .
23213251	0	p21	81,84	TRIM39	0,6	p21	TRIM39	644914	56658	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21 .
19356250	0	p21	13,16	Tax	76,79	p21	Tax	1026	6900	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of p21 -LRB- CIP1/WAF1 -RRB- expression by human_T-lymphotropic_virus_type_1 Tax requires transcriptional activation and mRNA stabilization .
7777546	0	p21	78,81	Transforming_growth_factor_beta	0,31	p21	Transforming growth factor beta	1026	7040	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor_beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism .
11739168	0	p21	109,112	Transforming_growth_factor_beta_1	0,33	p21	Transforming growth factor beta 1	12575(Tax:10090)	21803(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY arrest|nmod|cells mediates|dobj|arrest mediates|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21 -LRB- Cip1/Waf1 -RRB- or p27 -LRB- Kip1 -RRB- .
16177030	0	p21	105,108	Transforming_growth_factor_beta_1	0,33	p21	Transforming growth factor beta 1	1026	7040	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortex .
16998811	0	p21	83,86	VEGF	43,47	p21	VEGF	1026	7422	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
10942587	0	p21	142,145	WAF-1	146,151	p21	WAF-1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TGF-beta-mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21 -LRB- WAF-1 -RRB- expression .
12917633	0	p21	66,69	WAF-1	70,75	p21	WAF-1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Role of protein kinase C and the Sp1-p53 complex in activation of p21 -LRB- WAF-1 -RRB- expression by 12-O-tetradecanoylphorbol-13-acetate in human T cells .
15249198	0	p21	0,3	WAF-1	16,21	p21	WAF-1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	p21 -LRB- Cip-1 / SDI-1 / WAF-1 -RRB- expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells .
19738071	0	p21	37,40	WAF-1	41,46	p21	WAF-1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Pomalidomide and lenalidomide induce p21 WAF-1 expression in both lymphoma_and_multiple_myeloma through a LSD1-mediated epigenetic mechanism .
10420154	0	p21	16,19	WAF1	20,24	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Relationship of p21 -LRB- WAF1 -RRB- expression with disease-free survival and biochemical recurrence in prostate_adenocarcinomas -LRB- PCa -RRB- .
10679299	0	p21	19,22	WAF1	23,27	p21	WAF1	1026	1026	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	Binding domain for p21 -LRB- WAF1 -RRB- on the polypeptide chain of the protein kinase CK2_beta-subunit .
11021966	0	p21	66,69	WAF1	70,74	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epstein-barr virus nuclear antigen 2 retards cell growth , induces p21 -LRB- WAF1 -RRB- expression , and modulates p53 activity post-translationally .
11819597	0	p21	118,121	WAF1	122,126	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of in vivo patterns of caspase_3 gene expression in primary hepatocellular_carcinoma and its relationship to p21 -LRB- WAF1 -RRB- expression and hepatic apoptosis .
11888912	0	p21	47,50	WAF1	51,55	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Perifosine , a novel alkylphospholipid , induces p21 -LRB- WAF1 -RRB- expression in squamous_carcinoma cells through a p53-independent pathway , leading to loss in cyclin-dependent kinase activity and cell cycle arrest .
12706118	0	p21	109,112	WAF1	113,117	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
12782595	0	p21	40,43	WAF1	44,48	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Histone deacetylase inhibitors activate p21 -LRB- WAF1 -RRB- expression via ATM .
12824923	0	p21	147,150	WAF1	151,155	p21	WAF1	1026	1026	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Enhanced sensitivity to cis-diamminedichloroplatinum -LRB- II -RRB- of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21 -LRB- WAF1 -RRB- expression .
14996726	0	p21	46,49	WAF1	50,54	p21	WAF1	1026	1026	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Tbx2 directly represses the expression of the p21 -LRB- WAF1 -RRB- cyclin-dependent kinase inhibitor .
15069711	0	p21	52,55	WAF1	56,60	p21	WAF1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of p21 -LRB- WAF1 -RRB- and p53 and polymorphism of p21 -LRB- WAF1 -RRB- gene in gastric_carcinoma .
15248906	0	p21	40,43	WAF1	44,48	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Effects of hepatitis_B virus X gene on p21 -LRB- WAF1 -RRB- expression through p53-dependent and p53-independent pathways -RSB- .
15302882	0	p21	46,49	WAF1	50,54	p21	WAF1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interplay between HIV-1 Vpr and Sp1 modulates p21 -LRB- WAF1 -RRB- gene expression in human astrocytes .
15707594	0	p21	11,14	WAF1	16,20	p21	WAF1	1026	1026	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for p21 -LRB- WAF1 -RRB- in the cAMP-dependent differentiation of F9 teratocarcinoma cells into parietal endoderm .
16383301	0	p21	28,31	WAF1	32,36	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Prognostic significance of p21 -LRB- WAF1 -RRB- expression in osteosarcoma -RSB- .
16733561	0	p21	46,49	WAF1	50,54	p21	WAF1	1026	1026	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Quantitative analysis of the level of p53 and p21 -LRB- WAF1 -RRB- mRNA in human colon_cancer HT-29 cells treated with inositol_hexaphosphate .
19343784	0	p21	41,44	WAF1	45,49	p21	WAF1	24525(Tax:10116)	114851(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Arecoline-induced phosphorylated p53 and p21 -LRB- WAF1 -RRB- protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells .
19470386	0	p21	93,96	WAF1	97,101	p21	WAF1	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Rosmarinic_acid suppresses retinal_neovascularization via cell cycle arrest with increase of p21 -LRB- WAF1 -RRB- expression .
19818775	0	p21	16,19	WAF1	20,24	p21	WAF1	1026	1026	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Let-7a elevates p21 -LRB- WAF1 -RRB- levels by targeting of NIRF and suppresses the growth of A549_lung_cancer cells .
20039273	0	p21	39,42	WAF1	43,47	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Single-cell analysis of p16 -LRB- INK4a -RRB- and p21 -LRB- WAF1 -RRB- expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni_Syndrome fibroblasts .
20398565	0	p21	45,48	WAF1	49,53	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Platelet-derived growth factor-BB inhibited p21 -LRB- WAF1 -RRB- expression partially through transforming_growth_factor-beta signalling system in vascular smooth muscle cell -RSB- .
21124069	0	p21	64,67	WAF1	68,72	p21	WAF1	1026	1026	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Strategies to re-express epigenetically silenced p15 -LRB- INK4b -RRB- and p21 -LRB- WAF1 -RRB- genes in acute_myeloid_leukemia .
21555914	0	p21	47,50	WAF1	51,55	p21	WAF1	1026	1026	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	SRSF2 is required for sodium_butyrate-mediated p21 -LRB- WAF1 -RRB- induction and premature senescence in human lung_carcinoma cell lines .
21903579	0	p21	45,48	WAF1	49,53	p21	WAF1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p53-independent epigenetic repression of the p21 -LRB- WAF1 -RRB- gene in T-cell_acute_lymphoblastic_leukemia .
23894605	0	p21	32,35	WAF1	36,40	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p16 -LRB- INK4A -RRB- positively regulates p21 -LRB- WAF1 -RRB- expression by suppressing AUF1-dependent mRNA decay .
7496159	0	p21	47,50	WAF1	42,46	p21	WAF1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant_melanomas .
9616149	0	p21	14,17	WAF1	18,22	p21	WAF1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of p21 -LRB- WAF1 -RRB- expression during normal myeloid differentiation .
9694869	0	p21	34,37	WAF1	38,42	p21	WAF1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the p21 -LRB- WAF1 , CIP1 , SDI1 -RRB- gene by interleukin-6 type cytokines .
9722590	0	p21	8,11	WAF1	12,16	p21	WAF1	24525(Tax:10116)	114851(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Ectopic p21 -LRB- WAF1 -RRB- expression induces differentiation-specific cell cycle changes in PC12 cells characteristic of nerve growth factor treatment .
9770473	0	p21	23,26	WAF1	27,31	p21	WAF1	1026	1026	Gene	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	Activity and nature of p21 -LRB- WAF1 -RRB- complexes during the cell cycle .
10485911	0	p21	25,28	WAF1/CIP1	29,38	p21	WAF1/CIP1	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The lack of a functional p21 -LRB- WAF1/CIP1 -RRB- gene ameliorates progression to chronic_renal_failure .
10782880	0	p21	27,30	WAF1/CIP1	32,41	p21	WAF1/CIP1	1026	1026	Gene	Gene	p53|appos|START_ENTITY p53|appos|END_ENTITY	Protein expression of p53 , p21 -LRB- WAF1/CIP1 -RRB- , bcl-2 , Bax , cyclin_D1 and pRb in human colon_carcinomas .
10883667	0	p21	8,11	WAF1/CIP1	12,21	p21	WAF1/CIP1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Reduced p21 -LRB- WAF1/CIP1 -RRB- protein expression is predominantly related to altered p53 in hepatocellular_carcinomas .
11064455	0	p21	21,24	WAF1/CIP1	26,35	p21	WAF1/CIP1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sp1 and Sp3 activate p21 -LRB- WAF1/CIP1 -RRB- gene transcription in the Caco-2 colon_adenocarcinoma cell line .
11274368	0	p21	18,21	WAF1/CIP1	22,31	p21	WAF1/CIP1	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Myc represses the p21 -LRB- WAF1/CIP1 -RRB- promoter and interacts with Sp1/Sp3 .
11842244	0	p21	83,86	WAF1/CIP1	87,96	p21	WAF1/CIP1	1026	1026	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	The hinge region of the human papillomavirus type 8 E2_protein activates the human p21 -LRB- WAF1/CIP1 -RRB- promoter via interaction with Sp1 .
19895794	0	p21	25,28	WAF1/CIP1	29,38	p21	WAF1/CIP1	1026	1026	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Nuclear translocation of p21 -LRB- WAF1/CIP1 -RRB- protein prior to its cytosolic degradation by UV enhances DNA repair and survival .
24005533	0	p21	38,41	WAF1/CIP1	43,52	p21	WAF1/CIP1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aberrant promoter hypermethylation of p21 -LRB- WAF1/CIP1 -RRB- gene and its impact on expression and role of polymorphism in the risk of breast_cancer .
25483783	0	p21	17,20	WAF1/CIP1	22,31	p21	WAF1/CIP1	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	ANKHD1 represses p21 -LRB- WAF1/CIP1 -RRB- promoter and promotes multiple_myeloma cell growth .
8831553	0	p21	0,3	WAF1/CIP1	5,14	p21	WAF1/CIP1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- expression is induced in newly nondividing cells in diverse epithelia and during differentiation of the Caco-2 intestinal cell line .
8883416	0	p21	14,17	WAF1/CIP1	19,28	p21	WAF1/CIP1	1026	1026	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of p21 -LRB- WAF1/CIP1 -RRB- protein in clinical thyroid tissues .
9194578	0	p21	56,59	WAF1/CIP1	60,69	p21	WAF1/CIP1	1026	1026	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/CIP1 -RRB- in human cutaneous malignant_melanoma .
11212250	0	p21	29,32	WAF1/cip1	33,42	p21	WAF1/cip1	12575(Tax:10090)	12575(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Targeted inactivation of the p21 -LRB- WAF1/cip1 -RRB- gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal .
15664193	0	p21	14,17	WISp39	42,48	p21	WISp39	1026	63943	Gene	Gene	stability|amod|START_ENTITY stability|nmod|END_ENTITY	Regulation of p21 -LRB- WAF1/CIP1 -RRB- stability by WISp39 , a Hsp90 binding TPR protein .
9108440	0	p21	13,16	WT1	53,56	p21	WT1	1026	7490	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of p21 by the Wilms ' _ tumor suppressor gene WT1 .
10585285	0	p21	52,55	Waf1	56,60	p21	Waf1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	IGF-II enhances trichostatin_A-induced TGFbeta1 and p21 -LRB- Waf1 , Cip1 , sdi1 -RRB- expression in Hep3B cells .
18644983	0	p21	52,55	Zac1	75,79	p21	Zac1	1026	5325	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Modulation of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by Zac1 through the antagonistic regulators p53 and histone_deacetylase_1 in HeLa Cells .
22001409	0	p21	43,46	Zac1	0,4	p21	Zac1	1026	5325	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Zac1 , an Sp1-like protein , regulates human p21 -LRB- WAF1/Cip1 -RRB- gene expression in HeLa cells .
22761777	0	p21	31,34	activin	11,18	p21	activin	1026	83729	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of activin and TGFb on p21 in colon_cancer .
1658623	0	p21	80,83	c-rasH	127,133	p21	c-rasH	644914	80150	Gene	Gene	identification|nmod|START_ENTITY amino_acids|nsubj|identification amino_acids|nmod|END_ENTITY	The bovine papillomavirus E5 oncogene can cooperate with ras : identification of p21 amino_acids critical for transformation by c-rasH but not v-rasH .
6092927	0	p21	35,38	c-rasH	28,34	p21	c-rasH	644914	80150	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Metabolic turnover of human c-rasH p21 protein of EJ bladder_carcinoma and its normal cellular and viral homologs .
8622674	0	p21	0,3	cdk2	37,41	p21	cdk2	12575(Tax:10090)	12566(Tax:10090)	Gene	Gene	Disrupts|nsubj|START_ENTITY Disrupts|dobj|interaction interaction|nmod|END_ENTITY	p21 Disrupts the interaction between cdk2 and the E2F-p130 complex .
8668341	0	p21	0,3	cdk2	95,99	p21	cdk2	1026	1017	Gene	Gene	contains|nsubj|START_ENTITY contains|parataxis|required required|xcomp|inhibit inhibit|dobj|activity activity|amod|END_ENTITY	p21 contains independent binding sites for cyclin and cdk2 : both sites are required to inhibit cdk2 kinase activity .
9626358	0	p21	19,22	cdk2	90,94	p21	cdk2	1026	1017	Gene	Gene	level|nmod|START_ENTITY associated|nsubjpass|level associated|nmod|expression expression|nmod|END_ENTITY	Increased level of p21 in human ovarian_tumors is associated with increased expression of cdk2 , cyclin_A and PCNA .
10329038	0	p21	70,73	cdk4	80,84	p21	cdk4	1026	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10491389	0	p21	14,17	cip1	18,22	p21	cip1	1026	1026	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of p21 -LRB- cip1 -RRB- expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase .
10825236	0	p21	0,3	cip1	4,8	p21	cip1	1026	1026	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	p21 -LRB- cip1 -RRB- mRNA is controlled by endogenous transforming_growth_factor-beta1 in quiescent human hematopoietic stem/progenitor cells .
8668341	0	p21	0,3	cyclin	43,49	p21	cyclin	1026	5111	Gene	Gene	contains|nsubj|START_ENTITY contains|dobj|sites sites|nmod|END_ENTITY	p21 contains independent binding sites for cyclin and cdk2 : both sites are required to inhibit cdk2 kinase activity .
17130157	0	p21	72,75	cyclin-dependent_kinase_inhibitor_1A	34,70	p21	cyclin-dependent kinase inhibitor 1A	1026	1026	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Transcriptional regulation of the cyclin-dependent_kinase_inhibitor_1A -LRB- p21 -RRB- gene by NFI in proliferating human cells .
10936682	0	p21	62,65	cyclin_A	32,40	p21	cyclin A	1026	890	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression inhibition|nmod|END_ENTITY	Failure to induce inhibition of cyclin_A and up-regulation of p21 expression in phorbol_ester-resistant U937 cells by phorbol_ester .
16491347	0	p21	92,95	cyclin_A	45,53	p21	cyclin A	1026	890	Gene	Gene	inhibitors|dep|START_ENTITY Ki67|amod|inhibitors Ki67|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
19624419	0	p21	67,70	cyclin_A	52,60	p21	cyclin A	1026	890	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
25483089	0	p21	81,84	cyclin_A	98,106	p21	cyclin A	1026	890	Gene	Gene	CDK|dep|START_ENTITY Expression|appos|CDK Expression|appos|END_ENTITY	Expression of the p12 subunit of human DNA polymerase -LRB- Pol -RRB- , CDK inhibitor p21 -LRB- WAF1 -RRB- , Cdt1 , cyclin_A , PCNA and Ki-67 in relation to DNA replication in individual cells .
16426843	0	p21	47,50	cyclin_B1	74,83	p21	cyclin B1	24525(Tax:10116)	25203(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin_B1 expression in a p53-independent manner .
10329038	0	p21	70,73	cyclin_D1	86,95	p21	cyclin D1	1026	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
10398121	0	p21	67,70	cyclin_D1	72,81	p21	cyclin D1	1026	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	TP53 alterations in relation to the cell cycle-associated proteins p21 , cyclin_D1 , CDK4 , RB , MDM2 , and EGFR in cancers of the uterine corpus .
10762631	0	p21	0,3	cyclin_D1	23,32	p21	cyclin D1	1026	595	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	p21 is associated with cyclin_D1 , p16INK4a and pRb expression in resectable non-small_cell_lung_cancer .
11102889	0	p21	101,104	cyclin_D1	113,122	p21	cyclin D1	1026	595	Gene	Gene	p16|appos|START_ENTITY p16|amod|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11494229	0	p21	87,90	cyclin_D1	28,37	p21	cyclin D1	1026	595	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|localisation localisation|nmod|protein protein|amod|END_ENTITY	Subcellular localisation of cyclin_D1 protein in colorectal_tumours is associated with p21 -LRB- WAF1/CIP1 -RRB- expression and correlates with patient survival .
11751903	0	p21	0,3	cyclin_D1	19,28	p21	cyclin D1	644914	595	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|dobj|accumulation accumulation|amod|END_ENTITY	p21 -LRB- Cip1 -RRB- Promotes cyclin_D1 nuclear accumulation via direct inhibition of nuclear export .
12018448	0	p21	0,3	cyclin_D1	10,19	p21	cyclin D1	1026	595	Gene	Gene	p27|nummod|START_ENTITY p27|nummod|END_ENTITY	p21 , p27 , cyclin_D1 , and p53 in rectal_cancer : immunohistology with prognostic significance ?
17942917	0	p21	111,114	cyclin_D1	59,68	p21	cyclin D1	644914	595	Gene	Gene	occurs|nmod|START_ENTITY transformed|ccomp|occurs transformed|nsubj|suppression suppression|nmod|response response|nmod|Nutlin-3 Nutlin-3|nmod|END_ENTITY	p53-mediated growth suppression in response to Nutlin-3 in cyclin_D1 transformed cells occurs independently of p21 .
18343280	0	p21	27,30	cyclin_D1	48,57	p21	cyclin D1	644914	595	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|advcl|altering altering|dobj|expression expression|amod|END_ENTITY	Temsirolimus downregulates p21 without altering cyclin_D1 expression and induces autophagy and synergizes with vorinostat in mantle_cell_lymphoma .
19624419	0	p21	67,70	cyclin_D1	41,50	p21	cyclin D1	1026	595	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
24037529	0	p21	117,120	cyclin_D1	144,153	p21	cyclin D1	12575(Tax:10090)	12443(Tax:10090)	Gene	Gene	limits|nsubj|START_ENTITY limits|dobj|progression progression|nmod|inhibition inhibition|amod|END_ENTITY	PTEN ablation in Ras -LRB- Ha -RRB- / Fos skin_carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin_D1 / E2 inhibition .
24037529	0	p21	71,74	cyclin_D1	144,153	p21	cyclin D1	12575(Tax:10090)	12443(Tax:10090)	Gene	Gene	invokes|dobj|START_ENTITY invokes|xcomp|delay delay|advcl|limits limits|dobj|progression progression|nmod|inhibition inhibition|amod|END_ENTITY	PTEN ablation in Ras -LRB- Ha -RRB- / Fos skin_carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin_D1 / E2 inhibition .
7671232	0	p21	13,16	cyclin_D1	38,47	p21	cyclin D1	1026	595	Gene	Gene	p53|nmod|START_ENTITY induces|nsubj|p53 induces|dobj|synthesis synthesis|amod|END_ENTITY	p53 , through p21 -LRB- WAF1/CIP1 -RRB- , induces cyclin_D1 synthesis .
9191053	0	p21	98,101	cyclin_D1	32,41	p21	cyclin D1	644914	595	Gene	Gene	gene|amod|START_ENTITY activation|nmod|gene induces|dobj|activation induces|nsubj|expression expression|nmod|END_ENTITY	Regulated ectopic expression of cyclin_D1 induces transcriptional activation of the cdk inhibitor p21 gene without altering cell cycle progression .
10597246	0	p21	71,74	cyclin_E	97,105	p21	cyclin E	24525(Tax:10116)	25729(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin_E expression .
24384380	0	p21	108,111	early_growth_response_1	68,91	p21	early growth response 1	644914	1958	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Shikonin induces cell cycle arrest in human gastric_cancer -LRB- AGS -RRB- by early_growth_response_1 -LRB- Egr1 -RRB- - mediated p21 gene expression .
21278055	0	p21	71,74	glycogen_synthase_kinase-3b	15,42	p21	glycogen synthase kinase-3b	1026	2932	Gene	Gene	expression|amod|START_ENTITY Involvement|nmod|expression Involvement|nmod|END_ENTITY	Involvement of glycogen_synthase_kinase-3b in arsenic_trioxide-induced p21 expression .
21864408	0	p21	93,96	glycogen_synthase_kinase-3b	42,69	p21	glycogen synthase kinase-3b	644914	2932	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Phosphatidylinositol 3 ' - kinase , mTOR , and glycogen_synthase_kinase-3b mediated regulation of p21 in human urothelial_carcinoma cells .
22713239	0	p21	45,48	histone_acetyltransferase_PCAF	4,34	p21	histone acetyltransferase PCAF	644914	8850	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	The histone_acetyltransferase_PCAF regulates p21 transcription through stress-induced acetylation of histone H3 .
20028735	0	p21	38,41	histone_deacetylase_1	66,87	p21	histone deacetylase 1	12575(Tax:10090)	433759(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	The cyclin-dependent kinase inhibitor p21 is a crucial target for histone_deacetylase_1 as a regulator of cellular proliferation .
19276356	0	p21	19,22	histone_deacetylase_2	65,86	p21	histone deacetylase 2	644914	3066	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	FOXP3 up-regulates p21 expression by site-specific inhibition of histone_deacetylase_2 / histone_deacetylase_4 association to the locus .
11353054	0	p21	98,101	mdm-2	114,119	p21	mdm-2	12575(Tax:10090)	17246(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Transition from in situ to invasive testicular germ cell neoplasia is associated with the loss of p21 and gain of mdm-2 expression .
17395400	0	p21	49,52	mdm2	74,78	p21	mdm2	1026	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
27105517	0	p21	110,113	miR-663a	126,134	p21	miR-663a	644914	724033	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|nmod|END_ENTITY	ZNF224 , Kr ppel like zinc finger protein , induces cell growth and apoptosis-resistance by down-regulation of p21 and p53 via miR-663a .
16115229	0	p21	80,83	p14	90,93	p21	p14	644914	1029	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p21	49,52	p14	59,62	p21	p14	1026	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
15082782	0	p21	45,48	p150	0,4	p21	p150	1026	10036	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	p150 -LRB- Sal2 -RRB- is a p53-independent regulator of p21 -LRB- WAF1/CIP -RRB- .
21791360	0	p21	41,44	p150	102,106	p21	p150	1026	10036	Gene	Gene	transcription|amod|START_ENTITY inhibits|dobj|transcription inhibits|nmod|END_ENTITY	Human_papillomavirus_type_16 E6 inhibits p21 -LRB- WAF1 -RRB- transcription independently of p53 by inactivating p150 -LRB- Sal2 -RRB- .
10071127	0	p21	24,27	p16	29,32	p21	p16	644914	1029	Gene	Gene	p15|dep|START_ENTITY p15|dep|END_ENTITY	Alterations of the p53 , p21 , p16 , p15 and RAS genes in childhood_T-cell_acute_lymphoblastic_leukemia .
10207115	0	p21	13,16	p16	84,87	p21	p16	1026	1029	Gene	Gene	Induction|nmod|START_ENTITY mediated|nsubj|Induction mediated|nmod|END_ENTITY	Induction of p21 -LRB- WAF1/CIP1 -RRB- and inhibition of Cdk2 mediated by the tumor suppressor p16 -LRB- INK4a -RRB- .
15094066	0	p21	66,69	p16	53,56	p21	p16	1026	1029	Gene	Gene	Waf1|amod|START_ENTITY involved|nmod|Waf1 involved|nmod|activation activation|nmod|END_ENTITY	Sp1 is involved in the transcriptional activation of p16 -LRB- INK4 -RRB- by p21 -LRB- Waf1 -RRB- in HeLa cells .
16014626	0	p21	51,54	p16	97,100	p21	p16	1026	1029	Gene	Gene	redistribution|nmod|START_ENTITY induces|dobj|redistribution induces|nmod|up-regulation up-regulation|compound|END_ENTITY	Hepatocyte_growth_factor induces redistribution of p21 -LRB- CIP1 -RRB- and p27 -LRB- KIP1 -RRB- through ERK-dependent p16 -LRB- INK4a -RRB- up-regulation , leading to cell cycle arrest at G1 in HepG2 hepatoma cells .
16115229	0	p21	80,83	p16	75,78	p21	p16	644914	1029	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p21	49,52	p16	64,67	p21	p16	1026	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19624419	0	p21	67,70	p16	72,75	p21	p16	1026	1029	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
23754829	0	p21	75,78	p16	63,66	p21	p16	1026	1029	Gene	Gene	WAF1/Cip1|amod|START_ENTITY /|dobj|WAF1/Cip1 /|nsubj|evaluation evaluation|nmod|significance significance|nmod|END_ENTITY	An evaluation of the diagnostic and prognostic significance of p16 -LRB- INK4a -RRB- / p21 -LRB- WAF1/Cip1 -RRB- immunostaining in squamous_intraepithelial_lesions of the uterine cervix using liquid-based cytology specimens .
23894605	0	p21	32,35	p16	0,3	p21	p16	1026	1029	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p16 -LRB- INK4A -RRB- positively regulates p21 -LRB- WAF1 -RRB- expression by suppressing AUF1-dependent mRNA decay .
26422859	0	p21	59,62	p16	54,57	p21	p16	1026	1029	Gene	Gene	Bax|nummod|START_ENTITY END_ENTITY|appos|Bax	Determination-of apoptosis and cell cycle modulators -LRB- p16 , p21 , p27 , p53 , BCL-2 , Bax , BCL-xL , and cyclin_D1 -RRB- in thyroid_follicular_carcinoma , follicular_adenoma , and adenomatous nodules via a tissue microarray method .
12698196	0	p21	93,96	p18	69,72	p21	p18	1026	1031	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
12698196	0	p21	93,96	p19	81,84	p21	p19	1026	1032	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Antitumour effect of cyclin-dependent kinase inhibitors -LRB- p16 -LRB- INK4A -RRB- , p18 -LRB- INK4C -RRB- , p19 -LRB- INK4D -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- KIP1 -RRB- -RRB- on malignant_glioma cells .
10329038	0	p21	70,73	p27	75,78	p21	p27	1026	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
11903579	0	p21	35,38	p27	24,27	p21	p27	1026	3429	Gene	Gene	Waf1/Cip1|amod|START_ENTITY allows|nsubj|Waf1/Cip1 allows|nmod|examination examination|nmod|END_ENTITY	Combined examination of p27 -LRB- Kip1 -RRB- , p21 -LRB- Waf1/Cip1 -RRB- and p53 expression allows precise estimation of prognosis in patients with gastric_carcinoma .
12713563	0	p21	18,21	p27	60,63	p21	p27	24525(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Overexpression of p21 , cyclin_E and decreased expression of p27 in DMBA -LRB- 7 , _ 12-dimethylbenzanthracene -RRB- - induced rat ovarian_carcinogenesis .
14719078	0	p21	18,21	p27	23,26	p21	p27	644914	3429	Gene	Gene	E|amod|START_ENTITY E|amod|END_ENTITY	Protein levels of p21 , p27 , cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head_and_neck_squamous_cell_carcinomas .
16115229	0	p21	80,83	p27	85,88	p21	p27	644914	10671	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
16998811	0	p21	83,86	p27	72,75	p21	p27	1026	3429	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17088910	0	p21	147,150	p27	16,19	p21	p27	644914	10671	Gene	Gene	expression|nmod|START_ENTITY dependent|nmod|expression dependent|nsubj|Upregulation Upregulation|nmod|END_ENTITY	Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21 .
17395400	0	p21	49,52	p27	54,57	p21	p27	1026	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19624419	0	p21	67,70	p27	62,65	p21	p27	1026	3429	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
20605638	0	p21	81,84	p27	86,89	p21	p27	24525(Tax:10116)	83571(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY ratio|amod|END_ENTITY	Inhibition of C6 rat glioma proliferation by -LSB- Ru2Cl -LRB- Ibp -RRB- 4 -RSB- depends on changes in p21 , p27 , Bax/Bcl2 ratio and mitochondrial membrane potential .
22468256	0	p21	24,27	p27	29,32	p21	p27	644914	3429	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
8033213	0	p21	79,82	p27	0,3	p21	p27	12575(Tax:10090)	12576(Tax:10090)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	p27 , a novel inhibitor of G1 cyclin-Cdk protein kinase activity , is related to p21 .
11306695	0	p21	51,54	p38	15,18	p21	p38	644914	1432	Gene	Gene	induction|amod|START_ENTITY critical|nmod|induction receptors|amod|critical receptors|nsubj|activity activity|amod|END_ENTITY	High-intensity p38 kinase activity is critical for p21 -LRB- cip1 -RRB- induction and the antiproliferative function of G -LRB- i -RRB- protein-coupled receptors .
16344056	0	p21	82,85	p38	111,114	p21	p38	12575(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|acl|induction induction|nmod|kinase kinase|amod|END_ENTITY	Clostridium_difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21 -LRB- WAF1/CIP1 -RRB- induction via p38 mitogen-activated protein kinase .
21816217	0	p21	56,59	p38	65,68	p21	p38	644914	1432	Gene	Gene	START_ENTITY|nmod|manner manner|amod|END_ENTITY	Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKa dependent manner .
22227330	0	p21	137,140	p38	119,122	p21	p38	1026	1432	Gene	Gene	stabilization|amod|START_ENTITY stabilization|amod|END_ENTITY	Neferine , an alkaloid ingredient in lotus seed embryo , inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization .
22490020	0	p21	114,117	p38	154,157	p21	p38	1026	1432	Gene	Gene	induction|amod|START_ENTITY dependent|nmod|induction cells|amod|dependent cells|nmod|MAPK MAPK|amod|END_ENTITY	TGF-b-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-kB , p38 MAPK and ERK phosphorylations .
23751077	0	p21	81,84	p38	63,66	p21	p38	644914	1432	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression .
23759594	0	p21	48,51	p38	11,14	p21	p38	1026	1432	Gene	Gene	elongation|nmod|START_ENTITY END_ENTITY|nmod|elongation	A role for p38 in transcriptional elongation of p21 -LRB- CIP1 -RRB- in response to Aurora_B inhibition .
16479163	0	p21	22,25	p50	31,34	p21	p50	644914	4790	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of p21 with p50 , the small subunit of human DNA polymerase delta .
10070887	0	p21	0,3	p53	89,92	p21	p53	1026	7157	Gene	Gene	malignant_melanoma|amod|START_ENTITY malignant_melanoma|dep|relationship relationship|nmod|proliferation proliferation|compound|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- expression in stage I cutaneous malignant_melanoma : its relationship with p53 , cell proliferation and survival .
10071127	0	p21	24,27	p53	19,22	p21	p53	644914	7157	Gene	Gene	p15|dep|START_ENTITY p15|compound|END_ENTITY	Alterations of the p53 , p21 , p16 , p15 and RAS genes in childhood_T-cell_acute_lymphoblastic_leukemia .
10072848	0	p21	70,73	p53	65,68	p21	p53	644914	7157	Gene	Gene	p185|dep|START_ENTITY p185|compound|END_ENTITY	-LSB- The correlation between expression of oncogene protein products p53 , p21 , p185 and cell differentiation and prognosis in rhabdomyosarcoma -RSB- .
10347252	0	p21	18,21	p53	122,125	p21	p53	1026	7157	Gene	Gene	Overexpression|nmod|START_ENTITY decreases|nsubj|Overexpression decreases|dobj|arrest arrest|acl|induced induced|xcomp|lacking lacking|dobj|protein protein|amod|END_ENTITY	Overexpression of p21 -LRB- waf1 -RRB- decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein .
10407180	0	p21	39,42	p53	14,17	p21	p53	24525(Tax:10116)	301300(Tax:10116)	Gene	Gene	Activation|dep|START_ENTITY Activation|nmod|END_ENTITY	Activation of p53 and its target genes p21 -LRB- WAF1/Cip1 -RRB- and PAG608/Wig -1 in ischemic preconditioning .
10453961	0	p21	14,17	p53	64,67	p21	p53	644914	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|profile profile|compound|END_ENTITY	Expression of p21 and p27 in hepatoma cell lines with different p53 gene profile .
10466043	0	p21	5,8	p53	0,3	p21	p53	1026	7157	Gene	Gene	Waf1/Cip1|amod|START_ENTITY END_ENTITY|appos|Waf1/Cip1	p53 , p21 -LRB- Waf1/Cip1 -RRB- and cyclin_D1 protein expression and prognosis in esophageal_cancer .
10469214	0	p21	16,19	p53	0,3	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY expression|appos|expression expression|compound|END_ENTITY	p53 expression , p21 expression and the apoptotic index in endometrioid endometrial_adenocarcinoma .
10531398	0	p21	68,71	p53	17,20	p21	p53	1026	7157	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Tumor suppressor p53 but not cGMP mediates NO-induced expression of p21 -LRB- Waf1/Cip1/Sdi1 -RRB- in vascular smooth muscle cells .
10628797	0	p21	0,3	p53	79,82	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|study study|nmod|cases cases|nmod|analysis analysis|nmod|mutation/expression mutation/expression|compound|END_ENTITY	p21 expression in colorectal_carcinomas : a study on 103 cases with analysis of p53 gene mutation/expression and clinic-pathological correlations .
10632361	0	p21	25,28	p53	10,13	p21	p53	644914	7157	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated .
10677604	0	p21	111,114	p53	106,109	p21	p53	24525(Tax:10116)	301300(Tax:10116)	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|appos|proteins	The effects of N-methyl-N-nitrosourea and azoxymethane on focal cerebral_infarction and the expression of p53 , p21 proteins .
10682588	0	p21	27,30	p53	15,18	p21	p53	644914	7157	Gene	Gene	products|amod|START_ENTITY products|compound|END_ENTITY	-LSB- Expression of p53 and ras p21 gene products in malignant transformed V79 cell induced by various organic components of DEPs -RSB- .
10779360	0	p21	87,90	p53	82,85	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	genes|dep|START_ENTITY genes|compound|END_ENTITY	p53-mediated DNA repair responses to UV radiation : studies of mouse cells lacking p53 , p21 , and/or gadd45 genes .
10837373	0	p21	71,74	p53	110,113	p21	p53	644914	7157	Gene	Gene	protein|amod|START_ENTITY ubiquitination|nmod|protein increase|dobj|ubiquitination increase|nmod|stabilization stabilization|nmod|END_ENTITY	Polycyclic_aromatic_hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21 .
10842159	0	p21	62,65	p53	199,202	p21	p53	24525(Tax:10116)	301300(Tax:10116)	Gene	Gene	upregulates|amod|START_ENTITY vascular|nsubj|upregulates vascular|nmod|kinase kinase|nmod|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic_guanosine_monophosphate .
10862017	0	p21	81,84	p53	76,79	p21	p53	644914	7157	Gene	Gene	p16|dep|START_ENTITY p16|compound|END_ENTITY	Telomerase activity in head_and_neck_tumors after introduction of wild-type p53 , p21 , p16 , and E2F-1 genes by means of recombinant adenovirus .
10883667	0	p21	8,11	p53	78,81	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY related|nsubjpass|expression related|nmod|END_ENTITY	Reduced p21 -LRB- WAF1/CIP1 -RRB- protein expression is predominantly related to altered p53 in hepatocellular_carcinomas .
10955790	0	p21	32,35	p53	20,23	p21	p53	1026	7157	Gene	Gene	mdm-2|nummod|START_ENTITY mdm-2|compound|END_ENTITY	Predictive value of p53 , mdm-2 , p21 , and mib-1 for chemotherapy response in advanced breast_cancer .
11059670	0	p21	9,12	p53	98,101	p21	p53	644914	7157	Gene	Gene	regulation|amod|START_ENTITY regulation|acl|bearing bearing|dobj|END_ENTITY	Aberrant p21 regulation in radioresistant primary glioblastoma_multiforme cells bearing wild-type p53 .
11097743	0	p21	18,21	p53	80,83	p21	p53	1026	7157	Gene	Gene	induced|dobj|START_ENTITY TNF-alpha|acl|induced TNF-alpha|dep|WiDr WiDr|nmod|END_ENTITY	TNF-alpha induced p21 -LRB- WAF1 -RRB- but not Bax in colon_cancer cells WiDr with mutated p53 : important role of protein stabilization .
11102889	0	p21	101,104	p53	84,87	p21	p53	1026	7157	Gene	Gene	p16|appos|START_ENTITY END_ENTITY|appos|p16	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11158294	0	p21	32,35	p53	0,3	p21	p53	644914	7157	Gene	Gene	CHK1|nmod|START_ENTITY CHK1|nsubj|down-regulates down-regulates|compound|END_ENTITY	p53 down-regulates CHK1 through p21 and the retinoblastoma protein .
11175334	0	p21	71,74	p53	38,41	p21	p53	1026	7157	Gene	Gene	induction|amod|START_ENTITY correlates|nmod|induction correlates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo .
11317955	0	p21	15,18	p53	85,88	p21	p53	1026	7157	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|dep|study study|nmod|relation relation|nmod|mutation mutation|compound|END_ENTITY	-LSB- Expression of p21 WAF1/CIP1 protein in colorectal_cancers : study of its relation to p53 mutation and Ki67 antigen expression -RSB- .
11384995	0	p21	107,110	p53	134,137	p21	p53	1026	7157	Gene	Gene	gene|amod|START_ENTITY gene|nmod|protein protein|compound|END_ENTITY	Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by the p53 tumor suppressor protein .
11401317	0	p21	76,79	p53	0,3	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY levels|nmod|expression associated|nmod|levels associated|nsubjpass|mutations mutations|compound|missense missense|compound|END_ENTITY	p53 missense but not truncation mutations are associated with low levels of p21 -LRB- CIP1/WAF1 -RRB- mRNA expression in primary human sarcomas .
11429705	0	p21	59,62	p53	0,3	p21	p53	644914	7157	Gene	Gene	elements|amod|START_ENTITY containing|dobj|elements promoters|acl|containing transactivate|dobj|promoters transactivate|nsubj|mutants mutants|compound|END_ENTITY	p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements .
11585574	0	p21	96,99	p53	119,122	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	involving|xcomp|START_ENTITY involving|nmod|END_ENTITY	Nitric_oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic_guanosine_monophosphate .
11606096	0	p21	8,11	p53	103,106	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY expression|dep|overexpression overexpression|nmod|END_ENTITY	p53 and p21 expression in precancerous_lesions and carcinomas of the uterine cervix : overexpression of p53 predicts poor disease outcome .
11804280	0	p21	23,26	p53	28,31	p21	p53	644914	7157	Gene	Gene	pRb|compound|START_ENTITY pRb|dep|END_ENTITY	Cell cycle regulators -LRB- p21 , p53 , pRb -RRB- in oligodendrocytic_tumors : a study by novel tumor microarray technique .
11850848	0	p21	19,22	p53	53,56	p21	p53	1026	7157	Gene	Gene	variant|nmod|START_ENTITY p21B|appos|variant induced|nsubjpass|p21B induced|nmod|family family|compound|END_ENTITY	p21B , a variant of p21 -LRB- Waf1/Cip1 -RRB- , is induced by the p53 family .
11890931	0	p21	74,77	p53	52,55	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY phosphorylation|nmod|expression phosphorylation|nmod|END_ENTITY	SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression .
12040434	4	p21	892,895	p53	887,890	p21	p53	1026	7157	Gene	Gene	CLL|compound|START_ENTITY evolved|nsubj|CLL +|parataxis|evolved +|amod|END_ENTITY	Two p53 + / p21 + CLL evolved into RS .
12080472	0	p21	56,59	p53	19,22	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	transactivation|nmod|START_ENTITY induces|dobj|transactivation induces|nsubj|inhibition inhibition|nmod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
12085347	0	p21	24,27	p53	104,107	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|nmod|hepatocytes hepatocytes|acl:relcl|dependent dependent|nmod|END_ENTITY	Cyclin kinase inhibitor p21 potentiates bile_acid-induced apoptosis in hepatocytes that is dependent on p53 .
12477050	0	p21	103,106	p53	98,101	p21	p53	644914	7157	Gene	Gene	bax|dep|START_ENTITY bax|compound|END_ENTITY	Inhibition of cell growth by NB1011 requires high thymidylate_synthase levels and correlates with p53 , p21 , bax , and GADD45 induction .
12651158	0	p21	68,71	p53	104,107	p21	p53	1026	7157	Gene	Gene	Cip1|amod|START_ENTITY Cip1|appos|Waf1 Waf1|nmod|activation activation|nmod|END_ENTITY	Prolonged progestin treatment induces the promoter of CDK inhibitor p21 Cip1 , Waf1 through activation of p53 in human breast and endometrial_tumor cells .
12706118	0	p21	109,112	p53	7,10	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY reducing|dobj|expression senescing|advcl|reducing delay|advcl|senescing delay|nsubj|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
12824923	0	p21	147,150	p53	101,104	p21	p53	1026	7157	Gene	Gene	expression|compound|START_ENTITY gene|nmod|expression gene|compound|END_ENTITY	Enhanced sensitivity to cis-diamminedichloroplatinum -LRB- II -RRB- of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21 -LRB- WAF1 -RRB- expression .
12854173	0	p21	26,29	p53	21,24	p21	p53	1026	7157	Gene	Gene	Expressions|appos|START_ENTITY Expressions|appos|END_ENTITY	Expressions of PCNA , p53 , p21 -LRB- WAF-1 -RRB- and cell proliferation in fetal esophageal epithelia : comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal_cancer in Henan , _ North_China .
14707287	0	p21	68,71	p53	32,35	p21	p53	22070(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|expression expression|nmod|END_ENTITY	Prostate-specific expression of p53 -LRB- R172L -RRB- differentially regulates p21 , Bax , and mdm2 to inhibit prostate_cancer progression and prolong survival .
15069711	0	p21	52,55	p53	28,31	p21	p53	1026	7157	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Expression of p21 -LRB- WAF1 -RRB- and p53 and polymorphism of p21 -LRB- WAF1 -RRB- gene in gastric_carcinoma .
15099943	0	p21	36,39	p53	30,33	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY induces|nsubj|expression induces|dobj|END_ENTITY	Radiation_therapy induces the p53 -LRB- + -RRB- p21 -LRB- - -RRB- expression in squamous_cell_carcinomas of the uterine cervix .
15263796	0	p21	76,79	p53	186,189	p21	p53	1026	7157	Gene	Gene	patterns|nmod|START_ENTITY patterns|dep|correlation correlation|nmod|proteins proteins|appos|Rb Rb|dep|END_ENTITY	Expression patterns of cyclins D1 , E and cyclin-dependent kinase inhibitors p21 -LRB- Waf1/Cip1 -RRB- and p27 -LRB- Kip1 -RRB- in urothelial_carcinoma : correlation with other cell-cycle-related proteins -LRB- Rb , p53 , Ki-67 and PCNA -RRB- and clinicopathological features .
15507241	0	p21	12,15	p53	46,49	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	independent|amod|START_ENTITY independent|nmod|pathway pathway|compound|END_ENTITY	Increase in p21 expression independent of the p53 pathway in bleomycin-induced lung_fibrosis .
15655109	0	p21	68,71	p53	60,63	p21	p53	1026	7157	Gene	Gene	senescence|nsubj|START_ENTITY component|parataxis|senescence component|nmod|END_ENTITY	The p400 E1A-associated protein is a novel component of the p53 -- > p21 senescence pathway .
15678852	0	p21	39,42	p53	27,30	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of p53 and ras p21 protein expression in surgically treated non-small_cell_lung_carcinoma .
15685034	0	p21	51,54	p53	0,3	p21	p53	1026	7157	Gene	Gene	activation|amod|START_ENTITY independent|nmod|activation modulates|dobj|independent modulates|nsubj|END_ENTITY	p53 modulates radiation sensitivity independent of p21 transcriptional activation .
15735718	0	p21	13,16	p53	20,23	p21	p53	644914	7157	Gene	Gene	START_ENTITY|nmod|damage damage|nummod|END_ENTITY	Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities .
16012042	0	p21	8,11	p53	42,45	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY Loss|nmod|expression associated|nsubjpass|Loss associated|nmod|mutations mutations|compound|END_ENTITY	Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary_sinus_squamous_cell_carcinoma .
16054204	0	p21	102,105	p53	58,61	p21	p53	644914	7157	Gene	Gene	codon|nmod|START_ENTITY allele|nmod|codon allele|compound|END_ENTITY	Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21 , jointly mediate cervical_cancer susceptibility among Indian women .
16261158	0	p21	19,22	p53	52,55	p21	p53	1026	7157	Gene	Gene	transcripts|amod|START_ENTITY regulated|nsubjpass|transcripts regulated|nmod|END_ENTITY	Multiple alternate p21 transcripts are regulated by p53 in human cells .
16448826	0	p21	14,17	p53	120,123	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	antisense|amod|START_ENTITY effect|nmod|antisense oligodeoxynucleotides|nsubj|effect oligodeoxynucleotides|nmod|function function|compound|END_ENTITY	The effect of p21 antisense oligodeoxynucleotides on the radiosensitivity of nasopharyngeal_carcinoma cells with normal p53 function .
16537920	0	p21	109,112	p53	15,18	p21	p53	1026	7157	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|Acetylation Acetylation|nmod|END_ENTITY	Acetylation of p53 at lysine 373/382 by the histone_deacetylase inhibitor depsipeptide induces expression of p21 -LRB- Waf1/Cip1 -RRB- .
16616141	0	p21	93,96	p53	86,89	p21	p53	644914	7157	Gene	Gene	promoter|amod|START_ENTITY enhance|nmod|promoter enhance|dobj|properties properties|nmod|END_ENTITY	Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast_cancer cells .
16739126	0	p21	81,84	p53	65,68	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Arsenite inhibits p53 phosphorylation , DNA binding activity , and p53 target gene p21 expression in mouse epidermal JB6 cells .
16837908	0	p21	45,48	p53	40,43	p21	p53	1026	7157	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the cell cycle regulators p53 , p21 -LRB- WAF1/CIP1 -RRB- and p16 -LRB- INK4a -RRB- in human endometrial_adenocarcinoma .
16951143	0	p21	72,75	p53	0,3	p21	p53	644914	7157	Gene	Gene	promoters|nmod|START_ENTITY recruited|nmod|promoters recruited|nsubjpass|END_ENTITY	p53 is preferentially recruited to the promoters of growth_arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts .
16998811	0	p21	83,86	p53	55,58	p21	p53	1026	7157	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17317670	0	p21	66,69	p53	95,98	p21	p53	1026	7157	Gene	Gene	CDA1|dobj|START_ENTITY CDA1|nmod|END_ENTITY	Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21 -LRB- Waf1/Cip1 -RRB- by activating p53 and MEK/ERK1/2 MAPK pathways .
17339230	0	p21	32,35	p53	71,74	p21	p53	644914	7157	Gene	Gene	transcription|amod|START_ENTITY activates|dobj|transcription activates|nmod|END_ENTITY	c-Abl tyrosine kinase activates p21 transcription via interaction with p53 .
17395400	0	p21	49,52	p53	69,72	p21	p53	1026	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
17483019	0	p21	34,37	p53	116,119	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|lines lines|nmod|pathway pathway|amod|END_ENTITY	Bacillus Calmette-Gu rin induces p21 expression in human transitional carcinoma cell lines via an immediate early , p53 independent pathway .
17536310	0	p21	31,34	p53	20,23	p21	p53	1026	7157	Gene	Gene	Bcl-2|amod|START_ENTITY Immunoreactivity|appos|Bcl-2 Immunoreactivity|nmod|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
17585201	0	p21	0,3	p53	40,43	p21	p53	1026	7157	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|stability stability|compound|END_ENTITY	p21 -LRB- CDKN1A -RRB- is a negative regulator of p53 stability .
17760650	0	p21	28,31	p53	15,18	p21	p53	644914	7157	Gene	Gene	VEGF_C|appos|START_ENTITY END_ENTITY|appos|VEGF_C	Expressions of p53 , VEGF_C , p21 : could they be used in preoperative evaluation of lymph_node_metastasis of esophageal_squamous_cell_carcinoma ?
18024214	0	p21	117,120	p53	102,105	p21	p53	1026	7157	Gene	Gene	deregulation|nmod|START_ENTITY deregulation|nmod|kinases kinases|compound|END_ENTITY	Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21 - / - HCT116 colon_cancer cells .
18263706	0	p21	104,107	p53	16,19	p21	p53	644914	7157	Gene	Gene	upregulation|amod|START_ENTITY activity|dep|upregulation activity|compound|END_ENTITY	HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells : p21 upregulation and G2/M phase cell cycle arrest .
18269916	0	p21	13,16	p53	27,30	p21	p53	644914	7157	Gene	Gene	START_ENTITY|nmod|p65 p65|nmod|cells cells|nummod|END_ENTITY	Induction of p21 by p65 in p53 null cells treated with Doxorubicin .
18644983	0	p21	52,55	p53	116,119	p21	p53	1026	7157	Gene	Gene	gene|amod|START_ENTITY inhibitor|dobj|gene inhibitor|nmod|END_ENTITY	Modulation of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by Zac1 through the antagonistic regulators p53 and histone_deacetylase_1 in HeLa Cells .
18719376	0	p21	19,22	p53	0,3	p21	p53	644914	7157	Gene	Gene	promoter|amod|START_ENTITY Binding|nmod|promoter Binding|compound|END_ENTITY	p53 Binding to the p21 promoter is dependent on the nature of DNA damage .
18763134	0	p21	38,41	p53	13,16	p21	p53	1026	7157	Gene	Gene	effectors|dobj|START_ENTITY effectors|nsubj|Mechanism Mechanism|nmod|downstream downstream|compound|END_ENTITY	Mechanism of p53 downstream effectors p21 and Gadd45 in DNA damage surveillance .
19001415	0	p21	66,69	p53	52,55	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression interacts|xcomp|induce interacts|nmod|END_ENTITY	Monocytic_leukemia zinc finger -LRB- MOZ -RRB- interacts with p53 to induce p21 expression and cell-cycle arrest .
19147538	0	p21	97,100	p53	37,40	p21	p53	644914	403869(Tax:9615)	Gene	Gene	inhibitor|amod|START_ENTITY Establishment|nmod|inhibitor Establishment|nmod|model model|nmod|pathway pathway|compound|END_ENTITY	Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor .
19249676	0	p21	33,36	p53	142,145	p21	p53	644914	7157	Gene	Gene	downregulation|nmod|START_ENTITY provides|nsubj|downregulation provides|dobj|switch switch|nmod|apoptosis apoptosis|acl|induced induced|nmod|END_ENTITY	MDM2-dependent downregulation of p21 and hnRNP_K provides a switch between apoptosis and growth_arrest induced by pharmacologically activated p53 .
19428175	0	p21	55,58	p53	96,99	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY expression|amod|independent independent|nmod|END_ENTITY	Gambogic_acid down-regulates MDM2 oncogene and induces p21 -LRB- Waf1/CIP1 -RRB- expression independent of p53 .
19491257	0	p21	146,149	p53	16,19	p21	p53	644914	7157	Gene	Gene	gene|amod|START_ENTITY polymorphisms|nmod|gene polymorphisms|nummod|END_ENTITY	A novel type of p53 pathway dysfunction in chronic_lymphocytic_leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene .
19843844	0	p21	117,120	p53	0,3	p21	p53	644914	7157	Gene	Gene	promoter|amod|START_ENTITY patterns|nmod|promoter reveal|dobj|patterns revisited|ccomp|reveal revisited|nsubj|theories theories|nummod|END_ENTITY	p53 Pre - and post-binding event theories revisited : stresses reveal specific and dynamic p53-binding patterns on the p21 gene promoter .
20622899	0	p21	125,128	p53	59,62	p21	p53	1026	7157	Gene	Gene	targets|nmod|START_ENTITY END_ENTITY|nmod|targets	PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21 .
20871630	0	p21	0,3	p53	73,76	p21	p53	1026	7157	Gene	Gene	protect|nsubj|START_ENTITY protect|nmod|apoptosis apoptosis|acl|induced induced|nmod|activation activation|compound|END_ENTITY	p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation .
21148311	0	p21	40,43	p53	68,71	p21	p53	644914	7157	Gene	Gene	turnover|amod|START_ENTITY inhibition|nmod|turnover inhibition|amod|independent independent|nmod|END_ENTITY	14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53 .
21220944	0	p21	75,78	p53	63,66	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	targets|amod|START_ENTITY targets|nummod|END_ENTITY	Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways .
21368573	0	p21	0,3	p53	70,73	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	component|nsubj|START_ENTITY component|nmod|loop loop|acl:relcl|maintains maintains|dobj|program program|compound|END_ENTITY	p21 -LRB- WAF1 -RRB- is component of a positive feedback loop that maintains the p53 transcriptional program .
21402054	0	p21	145,148	p53	124,127	p21	p53	1026	7157	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Loss of p21 -LRB- Sdi1 -RRB- expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21 -LRB- Sdi1 -RRB- gene promoter .
21528264	0	p21	28,31	p53	67,70	p21	p53	1026	7157	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|dep|expression expression|compound|END_ENTITY	Correlation between reduced p21 -LRB- WAF1/CIP1 -RRB- expression and abnormal p53 expression in esophageal_carcinomas .
21559680	0	p21	87,90	p53	21,24	p21	p53	644914	7157	Gene	Gene	inhibitor|amod|START_ENTITY expression|nmod|inhibitor reduction|nmod|expression controls|nmod|reduction controls|nsubj|exclusion exclusion|nmod|END_ENTITY	Nuclear exclusion of p53 controls DNA-synthesis through reduction in the expression of p21 inhibitor of cyclin-dependent_kinase-2 .
21606339	0	p21	38,41	p53	0,3	p21	p53	644914	7157	Gene	Gene	promoter|amod|START_ENTITY nucleosomes|nmod|promoter binding|nmod|nucleosomes END_ENTITY|amod|binding	p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation .
21787748	0	p21	16,19	p53	64,67	p21	p53	644914	7157	Gene	Gene	proteins|amod|START_ENTITY proteins|nmod|sites sites|nmod|END_ENTITY	Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation .
21791360	0	p21	41,44	p53	82,85	p21	p53	1026	7157	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Human_papillomavirus_type_16 E6 inhibits p21 -LRB- WAF1 -RRB- transcription independently of p53 by inactivating p150 -LRB- Sal2 -RRB- .
21796649	0	p21	169,172	p53	149,152	p21	p53	644914	7157	Gene	Gene	proteins|amod|START_ENTITY associated|nmod|proteins associated|nmod|upregulation upregulation|nmod|END_ENTITY	Inhibitory effects of antagonists of growth_hormone_releasing_hormone on experimental_prostate_cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins .
21796649	0	p21	169,172	p53	184,187	p21	p53	644914	7157	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Inhibitory effects of antagonists of growth_hormone_releasing_hormone on experimental_prostate_cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins .
21933903	0	p21	83,86	p53	41,44	p21	p53	1026	7157	Gene	Gene	element|appos|START_ENTITY bound|nmod|element bound|nsubj|structure structure|nmod|tetramer tetramer|compound|END_ENTITY	Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A -LRB- p21 -RRB- p53-response element .
22135025	0	p21	19,22	p53	55,58	p21	p53	644914	7157	Gene	Gene	p53|nummod|START_ENTITY Expression|nmod|p53 Expression|parataxis|predicts predicts|nsubj|END_ENTITY	Expression of p53 , p21 and cyclin_D1 in penile_cancer : p53 predicts poor prognosis .
22165824	0	p21	0,3	p53	20,23	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|mice mice|compound|END_ENTITY	p21 protects `` Super p53 '' mice from the radiation-induced gastrointestinal_syndrome .
22244827	0	p21	131,134	p53	90,93	p21	p53	644914	7157	Gene	Gene	E1A-dependent|dep|START_ENTITY suppression|amod|E1A-dependent overexpression|nmod|suppression overexpression|nsubj|mechanism mechanism|nmod|END_ENTITY	A novel apoptotic mechanism of genetically engineered adenovirus-mediated_tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression .
22427654	0	p21	26,29	p53	90,93	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression requires|nsubj|induction requires|dobj|factors factors|compound|END_ENTITY	Sulforaphane induction of p21 -LRB- Cip1 -RRB- cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent .
22468256	0	p21	24,27	p53	14,17	p21	p53	644914	7157	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
22825333	0	p21	27,30	p53	86,89	p21	p53	1026	7157	Gene	Gene	regulation|nmod|START_ENTITY protein|nsubj|regulation protein|nmod|tumors tumors|nummod|END_ENTITY	Differential regulation of p21 -LRB- waf1 -RRB- protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications .
22995373	0	p21	65,68	p53	60,63	p21	p53	644914	7157	Gene	Gene	bax|dep|START_ENTITY bax|compound|END_ENTITY	Immunohistochemistry with apoptotic-antiapoptotic proteins -LRB- p53 , p21 , bax , bcl-2 -RRB- , c-kit , telomerase , and metallothionein as a diagnostic aid in benign , borderline , and malignant serous and mucinous ovarian_tumors .
23177619	0	p21	31,34	p53	46,49	p21	p53	1026	7157	Gene	Gene	WAF/CIP1|amod|START_ENTITY analysis|nmod|WAF/CIP1 analysis|appos|proteins proteins|compound|END_ENTITY	Correlation analysis of c-myc , p21 -LRB- WAF/CIP1 -RRB- , p53 , C-erbB-2 and COX-2 proteins in esophageal_squamous_cell_carcinoma .
23382584	0	p21	32,35	p53	36,39	p21	p53	644914	7157	Gene	Gene	status|amod|START_ENTITY status|compound|END_ENTITY	Association of p21 , p21 p27 and p21 p53 status to histological subtypes and prognosis in low-stage_epithelial_ovarian_cancer .
23470540	0	p21	51,54	p53	24,27	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibition|nmod|expression inhibition|nsubj|effects effects|nmod|END_ENTITY	Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression .
23665218	0	p21	125,128	p53	0,3	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	effectors|dobj|START_ENTITY effectors|advmod|efficiently efficiently|nmod:npmod|END_ENTITY	p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21 , Puma , and Noxa .
23665236	0	p21	74,77	p53	93,96	p21	p53	1026	7157	Gene	Gene	independent|amod|START_ENTITY inhibitor|amod|independent inhibitor|nmod|END_ENTITY	EVI1 targets Np63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon_cancer cells .
24134839	0	p21	48,51	p53	24,27	p21	p53	644914	7157	Gene	Gene	sites|amod|START_ENTITY Preferential|nmod|sites Preferential|nmod|suppressor suppressor|compound|END_ENTITY	Preferential binding of p53 tumor suppressor to p21 promoter sites that contain inverted repeats capable of forming cruciform structure .
24212661	0	p21	86,89	p53	25,28	p21	p53	644914	7157	Gene	Gene	Status|amod|START_ENTITY Dependent|nmod|Status Dependent|nsubj|Impact Impact|nmod|Expression Expression|compound|END_ENTITY	The Prognostic Impact of p53 Expression on Sporadic Colorectal_Cancer Is Dependent on p21 Status .
24451377	0	p21	105,108	p53	139,142	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cascade cascade|compound|END_ENTITY	The Chinese herb isolate yuanhuacine -LRB- YHL-14 -RRB- induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade .
24594805	0	p21	163,166	p53	46,49	p21	p53	644914	7157	Gene	Gene	promoter|amod|START_ENTITY involved|nmod|promoter involved|nsubjpass|Interaction Interaction|nmod|domain domain|nmod|part part|compound|END_ENTITY	Interaction between transactivation domain of p53 and middle part of TBP-like_protein -LRB- TLP -RRB- is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter .
24868967	0	p21	36,39	p53	10,13	p21	p53	1026	7157	Gene	Gene	proteins|amod|START_ENTITY interaction|nmod|proteins END_ENTITY|nmod|interaction	-LSB- Roles of p53 in the interaction of p21 and cell cycle proteins induced by benzo _ -LSB- a -RSB- _ pyrene -RSB- .
25532599	0	p21	0,3	p53	5,8	p21	p53	644914	7157	Gene	Gene	START_ENTITY|appos|polymorphisms polymorphisms|compound|TP53BP1 TP53BP1|compound|END_ENTITY	p21 , p53 , TP53BP1 and p73 polymorphisms and the risk of gastric_cardia_adenocarcinoma in a Chinese population .
25773855	0	p21	70,73	p53	65,68	p21	p53	644914	7157	Gene	Gene	Modulating|nummod|START_ENTITY Modulating|nummod|END_ENTITY	Silibilin-Induces Apoptosis in Breast_Cancer Cells by Modulating p53 , p21 , Bak and Bcl-xl Pathways .
25835715	0	p21	19,22	p53	14,17	p21	p53	1026	7157	Gene	Gene	establishing|nsubj|START_ENTITY Expression|dep|establishing Expression|nmod|END_ENTITY	Expression of p53 , p21 -LRB- CIP1/WAF1 -RRB- and eIF4E in the adjacent tissues of oral_squamous_cell_carcinoma : establishing the molecular boundary and a cancer progression model .
26680804	0	p21	48,51	p53	116,119	p21	p53	1026	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|Relationship Relationship|nmod|Status Status|compound|END_ENTITY	Expression of Cyclin-dependent Kinase Inhibitor p21 -LRB- WAF1/CIP1 -RRB- in Non-small_Cell_Lung_Carcinomas : Relationship with p53 Status and Proliferative Activity .
7577479	0	p21	18,21	p53	23,26	p21	p53	644914	7157	Gene	Gene	ras|nummod|START_ENTITY ras|nummod|END_ENTITY	Expression of ras p21 , p53 and c-erbB-2 in advanced breast_cancer and response to first line hormonal therapy .
7832809	0	p21	57,60	p53	0,3	p21	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	p53 controls proliferation of early B lineage cells by a p21 -LRB- WAF1/Cip1 -RRB- - independent pathway .
7912978	0	p21	54,57	p53	33,36	p21	p53	644914	7157	Gene	Gene	v-erb|dobj|START_ENTITY v-erb|nsubj|Expression Expression|nmod|EGF-receptor EGF-receptor|nummod|END_ENTITY	Expression of EGF , EGF-receptor , p53 , v-erb B and ras p21 in colorectal_neoplasms by immunostaining paraffin-embedded tissues .
7936668	0	p21	83,86	p53	128,131	p21	p53	1026	7157	Gene	Gene	expression|compound|START_ENTITY expression|nmod|absence absence|nmod|END_ENTITY	Induction of differentiation in human promyelocytic_HL-60_leukemia cells activates p21 , WAF1/CIP1 , expression in the absence of p53 .
8619835	0	p21	60,63	p53	112,115	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY suppresses|dobj|expression suppresses|nmod|cells cells|acl|containing containing|dobj|END_ENTITY	DNA-dependent_protein_kinase inhibitor -LRB- OK-1035 -RRB- suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin .
8625071	0	p21	39,42	p53	27,30	p21	p53	644914	7157	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of p53 and ras p21 expression in nonsmall cell lung_cancer .
8727942	0	p21	44,47	p53	32,35	p21	p53	644914	7157	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical analysis of p53 and ras p21 expression in colorectal_adenomas and early carcinomas .
8945609	0	p21	40,43	p53	35,38	p21	p53	644914	7157	Gene	Gene	genes|amod|START_ENTITY END_ENTITY|appos|genes	Mutations and polymorphisms in the p53 , p21 and p16 genes in oral_carcinomas of Indian betel quid chewers .
9120716	0	p21	65,68	p53	30,33	p21	p53	1026	7157	Gene	Gene	protein|amod|START_ENTITY express|dobj|protein Relationship|xcomp|express Relationship|nmod|protein protein|compound|END_ENTITY	Relationship between abnormal p53 protein and failure to express p21 protein in human breast_carcinomas .
9177263	0	p21	39,42	p53	55,58	p21	p53	644914	7157	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	In vitro transcriptional activation of p21 promoter by p53 .
9215397	0	p21	14,17	p53	29,32	p21	p53	644914	7157	Gene	Gene	products|amod|START_ENTITY products|compound|END_ENTITY	Expression of p21 and mutant p53 gene products in residual prostatic tumor cells after radical radiotherapy .
9215868	0	p21	16,19	p53	102,105	p21	p53	1026	7157	Gene	Gene	gene|amod|START_ENTITY Introduction|nmod|gene Introduction|nmod|cervix cervix|nmod|END_ENTITY	Introduction of p21 -LRB- Waf1/Cip1 -RRB- gene into a carcinoma cell line of the uterine cervix with inactivated p53 .
9218130	0	p21	49,52	p53	17,20	p21	p53	1026	7157	Gene	Gene	mRNA|amod|START_ENTITY protein|nmod|mRNA protein|compound|END_ENTITY	Modifications of p53 protein and accumulation of p21 and gadd45 mRNA in TGF-beta_1 growth inhibited cells .
9224526	0	p21	75,78	p53	26,29	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|Accumulation Accumulation|nmod|END_ENTITY	Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression .
9230213	0	p21	14,17	p53	76,79	p21	p53	644914	7157	Gene	Gene	induction|amod|START_ENTITY induction|nmod|gamma-irradiation gamma-irradiation|nmod|END_ENTITY	p53-dependent p21 induction following gamma-irradiation without concomitant p53 induction in a human peripheral_neuroepithelioma cell line .
9233781	0	p21	70,73	p53	32,35	p21	p53	644914	7157	Gene	Gene	sites|nmod|START_ENTITY genes|nsubj|sites genes|nmod|evidence evidence|nmod|binding binding|nmod|END_ENTITY	In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation .
9236898	0	p21	4,7	p53	57,60	p21	p53	644914	7157	Gene	Gene	immunoreactivity|amod|START_ENTITY Ras|dobj|immunoreactivity Ras|nmod|expression expression|compound|END_ENTITY	Ras p21 protein immunoreactivity and its relationship to p53 expression and prognosis in gallbladder_and_extrahepatic_biliary_carcinoma .
9252195	0	p21	151,154	p53	24,27	p21	p53	1026	7157	Gene	Gene	correlates|dobj|START_ENTITY correlates|nsubj|accumulation accumulation|nmod|END_ENTITY	Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/CIP1 -RRB- in pancreatic_cancer .
9275025	0	p21	11,14	p53	54,57	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY Absence|nmod|expression associated|nsubjpass|Absence associated|nmod|END_ENTITY	Absence of p21 expression is associated with abnormal p53 in human breast_carcinomas .
9575175	0	p21	94,97	p53	61,64	p21	p53	1026	7157	Gene	Gene	induction|nmod|START_ENTITY regulate|dobj|induction acts|xcomp|regulate acts|advmod|upstream upstream|nmod|END_ENTITY	Serine/threonine protein phosphatase_type_5 acts upstream of p53 to regulate the induction of p21 -LRB- WAF1/Cip1 -RRB- and mediate growth arrest .
9607571	0	p21	25,28	p53	51,54	p21	p53	644914	7157	Gene	Gene	expression|nmod|START_ENTITY related|nsubjpass|expression related|nmod|protein protein|compound|END_ENTITY	Infrequent expression of p21 is related to altered p53 protein in pancreatic_carcinoma .
9664113	0	p21	18,21	p53	13,16	p21	p53	644914	7157	Gene	Gene	regulation|compound|START_ENTITY END_ENTITY|appos|regulation	Differential p53 , p21 , mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53 .
9664113	0	p21	18,21	p53	94,97	p21	p53	644914	7157	Gene	Gene	regulation|compound|START_ENTITY regulation|acl:relcl|overexpress overexpress|dobj|END_ENTITY	Differential p53 , p21 , mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53 .
9685373	0	p21	49,52	p53	80,83	p21	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells .
9786925	0	p21	65,68	p53	132,135	p21	p53	1026	7157	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53 .
9811471	0	p21	124,127	p53	152,155	p21	p53	644914	7157	Gene	Gene	activity|nmod|START_ENTITY inhibition|nmod|activity independent|nmod|inhibition independent|nmod|END_ENTITY	Lovastatin mediated G1_arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27 , independent of p53 .
9826721	0	p21	111,114	p53	97,100	p21	p53	644914	7157	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression associated|xcomp|induce associated|nmod|failure failure|nmod|END_ENTITY	The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 -LRB- BAX -RRB- expression .
9873247	0	p21	36,39	p53	31,34	p21	p53	1026	7157	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A clinicopathological study of p53 , p21 -LRB- WAF1/CIP1 -RRB- and cyclin_D1 expression in human prostate_cancers .
22468256	0	p21	24,27	p63	19,22	p21	p63	644914	8626	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
22305266	0	p21	12,15	p65	27,30	p21	p65	644914	5970	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Cytoplasmic p21 induced by p65 prevents doxorubicin-induced cell death in pancreatic_carcinoma cell line .
11496322	0	p21	131,134	pRB	80,83	p21	pRB	1026	5925	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Doenjang hexane fraction-induced G1_arrest is associated with the inhibition of pRB phosphorylation and induction of Cdk inhibitor p21 in human breast_carcinoma MCF-7 cells .
12689523	0	p21	141,144	pRB	90,93	p21	pRB	1026	5925	Gene	Gene	START_ENTITY|amod|beta-lapachone beta-lapachone|nmod|down-regulation down-regulation|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Suppression_of_human_prostate_cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21 -LRB- WAF1/CIP1 -RRB- .
11329487	0	p21	32,35	pRb	70,73	p21	pRb	644914	5925	Gene	Gene	expression|nmod|START_ENTITY hyperphosphorylated|nsubj|expression hyperphosphorylated|dobj|END_ENTITY	Ethanol decreases expression of p21 and increases hyperphosphorylated pRb in cell lines of squamous_cell_carcinomas of the head and neck .
12383116	0	p21	14,17	pRb	67,70	p21	pRb	1026	5925	Gene	Gene	START_ENTITY|acl|derived derived|dobj|inhibitors inhibitors|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Highly potent p21 -LRB- WAF1 -RRB- - derived peptide inhibitors of CDK-mediated pRb phosphorylation : delineation and structural insight into their interactions with cyclin_A .
15875733	0	p21	44,47	pRb	49,52	p21	pRb	644914	5925	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Correlations of cell cycle regulators -LRB- p53 , p21 , pRb and mdm2 -RRB- and c-erbB-2 with biological markers of proliferation and overall survival in breast_cancer .
9418909	0	p21	11,14	pRb	80,83	p21	pRb	1026	5925	Gene	Gene	Cip1/Waf1|amod|START_ENTITY Effects|nmod|Cip1/Waf1 transitions|nsubj|Effects transitions|parataxis|determinant determinant|nsubj|END_ENTITY	Effects of p21 -LRB- Cip1/Waf1 -RRB- at both the G1/S and the G2/M cell cycle transitions : pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication .
15041706	0	p21	17,20	peroxisome_proliferator-activated_receptor_gamma	40,88	p21	peroxisome proliferator-activated receptor gamma	644914	5468	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of p21 gene expression by peroxisome_proliferator-activated_receptor_gamma in human lung_carcinoma cells .
12782287	0	p21	64,67	phospholipase_D1	76,92	p21	phospholipase D1	12575(Tax:10090)	18805(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY inhibitor|dobj|gene inhibitor|nmod|END_ENTITY	Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase_D1 and D2 .
12509454	0	p21	0,3	proliferating_cell_nuclear_antigen	19,53	p21	proliferating cell nuclear antigen	12575(Tax:10090)	18538(Tax:10090)	Gene	Gene	Controls|nsubj|START_ENTITY Controls|dobj|level level|compound|END_ENTITY	p21 -LRB- CIP1 -RRB- Controls proliferating_cell_nuclear_antigen level in adult cardiomyocytes .
8420353	0	p21	27,30	ras	14,17	p21	ras	644914	3265	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues : correlation with histopathologic features and receptors for estrogen , progesterone , and epidermal growth factor .
10467350	0	p21	22,25	sdi1	26,30	p21	sdi1	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells : implication for senescence-directed molecular therapy for cancer .
11389691	0	p21	45,48	thymidine_kinase_1	21,39	p21	thymidine kinase 1	1026	7083	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human thymidine_kinase_1 with p21 -LRB- Waf1 -RRB- .
10878024	0	p21	54,57	transforming_growth_factor-beta	83,114	p21	transforming growth factor-beta	1026	7040	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Role of Smad proteins and transcription factor Sp1 in p21 -LRB- Waf1/Cip1 -RRB- regulation by transforming_growth_factor-beta .
20398565	0	p21	45,48	transforming_growth_factor-beta	84,115	p21	transforming growth factor-beta	1026	7040	Gene	Gene	expression|amod|START_ENTITY inhibited|dobj|expression inhibited|nmod|system system|amod|END_ENTITY	-LSB- Platelet-derived growth factor-BB inhibited p21 -LRB- WAF1 -RRB- expression partially through transforming_growth_factor-beta signalling system in vascular smooth muscle cell -RSB- .
12217602	0	p21	91,94	transforming_growth_factor_beta	130,161	p21	transforming growth factor beta	1026	7040	Gene	Gene	down-regulation|amod|START_ENTITY down-regulation|dep|effect effect|nmod|END_ENTITY	Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21 -LRB- WAF1 -RRB- down-regulation -- effect of transforming_growth_factor_beta .
16284627	0	p21	30,33	transforming_growth_factor_beta	63,94	p21	transforming growth factor beta	1026	7040	Gene	Gene	activation|nmod|START_ENTITY mediated|nsubjpass|activation mediated|nmod|pathway pathway|compound|END_ENTITY	Transcriptional activation of p21 by Tranilast is mediated via transforming_growth_factor_beta signal pathway .
9819384	0	p21	0,3	transforming_growth_factor_beta	94,125	p21	transforming growth factor beta	1026	7040	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|element element|amod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming_growth_factor_beta - and Sp1-responsive element : involvement of the small GTPase rhoA .
15300203	0	p21	122,125	transforming_growth_factor_beta_1	20,53	p21	transforming growth factor beta 1	12575(Tax:10090)	21803(Tax:10090)	Gene	Gene	downregulation|nmod|START_ENTITY confers|nmod|downregulation confers|nsubj|exposure exposure|nmod|END_ENTITY	Chronic exposure of transforming_growth_factor_beta_1 confers a more aggressive tumor phenotype through downregulation of p21 -LRB- WAF1/CIP1 -RRB- in conditionally immortalized pancreatic epithelial cells .
8641969	0	p21	111,114	transforming_growth_factor_beta_1	29,62	p21	transforming growth factor beta 1	1026	7040	Gene	Gene	induction|nmod|START_ENTITY associated|nmod|induction associated|nsubjpass|Inhibition Inhibition|nmod|growth growth|nmod|END_ENTITY	Inhibition of cell growth by transforming_growth_factor_beta_1 is associated with p53-independent induction of p21 in gastric_carcinoma cells .
10906181	0	p21	18,21	waf1	22,26	p21	waf1	1026	1026	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of p21 -LRB- waf1 -RRB- in human_T-cell_lymphotropic_virus_type_1-infected cells and its association with cyclin_A / cdk2 .
11574165	0	p21	30,33	waf1	34,38	p21	waf1	1026	1026	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Transcriptional repression of p21 -LRB- waf1 -RRB- promoter by hepatitis_B_virus X protein via a p53-independent pathway .
17412493	0	p21	131,134	waf1	135,139	p21	waf1	1026	1026	Gene	Gene	upregulation|compound|START_ENTITY upregulation|appos|END_ENTITY	1alpha,25-Dihydroxyvitamin _ D -LRB- 3 -RRB- antiproliferative actions involve vitamin_D_receptor-mediated activation of MAPK pathways and AP-1 / p21 -LRB- waf1 -RRB- upregulation in human osteosarcoma .
20600642	0	p21	15,18	waf1	20,24	p21	waf1	1026	1026	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of p21 -LRB- waf1 -RRB- in merlin deficient sporadic_vestibular_schwannomas .
21552919	0	p21	29,32	waf1	33,37	p21	waf1	1026	1026	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	P53-independent induction of p21 -LRB- waf1 -RRB- pathway is preserved during tumor progression .
10606183	0	p21	40,43	waf1-cip1	45,54	p21	waf1-cip1	1026	1026	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	Expression of bcl-2 , c-erbB-2 , p53 , and p21 -LRB- waf1-cip1 -RRB- protein in thyroid_carcinomas .
24380729	0	p21-Activated_kinase1	0,21	NADPH-oxidase_2	56,71	p21-Activated kinase1	NADPH-oxidase 2	18479(Tax:10090)	13058(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	p21-Activated_kinase1 -LRB- Pak1 -RRB- is a negative regulator of NADPH-oxidase_2 in ventricular myocytes .
22096607	0	p21-Activated_kinase_1	0,22	BAD	45,48	p21-Activated kinase 1	BAD	5058	572	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	p21-Activated_kinase_1 -LRB- Pak1 -RRB- phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112 .
21949127	0	p21-Activated_kinase_3	0,22	PAK3	24,28	p21-Activated kinase 3	PAK3	5063	5063	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	p21-Activated_kinase_3 -LRB- PAK3 -RRB- protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor .
22710715	0	p21-Activated_kinase_4	0,22	CREB	68,72	p21-Activated kinase 4	CREB	10298	1385	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	p21-Activated_kinase_4 promotes prostate_cancer progression through CREB .
26160174	0	p21-activated_Kinase_1	86,108	CKIP-1	62,68	p21-activated Kinase 1	CKIP-1	5058	51177	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	The Role of the Pleckstrin Homology Domain-Containing Protein CKIP-1 in Activation of p21-activated_Kinase_1 -LRB- PAK1 -RRB- .
15849194	0	p21-activated_Kinase_1	0,22	Raf-1	59,64	p21-activated Kinase 1	Raf-1	5058	5894	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|nmod|END_ENTITY	p21-activated_Kinase_1 -LRB- Pak1 -RRB- - dependent phosphorylation of Raf-1 regulates its mitochondrial localization , phosphorylation of BAD , and Bcl-2 association .
20400510	0	p21-activated_kinase-1	16,38	LKB1	0,4	p21-activated kinase-1	LKB1	5058	6794	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	LKB1 suppresses p21-activated_kinase-1 -LRB- PAK1 -RRB- by phosphorylation of Thr109 in the p21-binding domain .
9298982	0	p21-activated_kinase_1	16,38	PAK1	40,44	p21-activated kinase 1	PAK1	29431(Tax:10116)	29431(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of p21-activated_kinase_1 -LRB- PAK1 -RRB- to pinocytic vesicles and cortical actin structures in stimulated cells .
16472651	0	p21-activated_kinase_1	29,51	RhoGDI	19,25	p21-activated kinase 1	RhoGDI	5058	396	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of RhoGDI by p21-activated_kinase_1 .
15845372	0	p21-activated_kinase_1	68,90	dynein_light_chain_2	18,38	p21-activated kinase 1	dynein light chain 2	5058	140735	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of dynein_light_chain_2 as an interaction partner of p21-activated_kinase_1 .
23818969	0	p21-activated_kinase_3	0,22	AP-1	36,40	p21-activated kinase 3	AP-1	18481(Tax:10090)	16476(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	p21-activated_kinase_3 -LRB- PAK3 -RRB- is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts .
24366569	0	p21-activated_kinase_4	12,34	CREB	130,134	p21-activated kinase 4	CREB	10298	1385	Gene	Gene	inhibitor|amod|START_ENTITY PF-3758309|appos|inhibitor suppresses|nsubj|PF-3758309 suppresses|dobj|migration migration|nmod|cells cells|nmod|regulation regulation|nmod|END_ENTITY	PF-3758309 , p21-activated_kinase_4 inhibitor , suppresses migration and invasion of A549 human lung_cancer cells via regulation of CREB , NF-kB , and b-catenin signalings .
25705811	0	p21-activated_kinase_4	105,127	PAK4	129,133	p21-activated kinase 4	PAK4	10298	10298	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Design , synthesis and biological evaluation of 1-phenanthryl-tetrahydroisoquinoline derivatives as novel p21-activated_kinase_4 -LRB- PAK4 -RRB- inhibitors .
21832093	0	p21-activated_kinase_4	52,74	Protein_kinase_D	0,16	p21-activated kinase 4	Protein kinase D	10298	5587	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Protein_kinase_D regulates cofilin activity through p21-activated_kinase_4 .
12529371	0	p21-activated_protein_kinase_4	0,30	keratinocyte_growth_factor_receptor	57,92	p21-activated protein kinase 4	keratinocyte growth factor receptor	10298	2263	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	p21-activated_protein_kinase_4 -LRB- PAK4 -RRB- interacts with the keratinocyte_growth_factor_receptor and participates in keratinocyte_growth_factor-mediated inhibition of oxidant-induced cell death .
21597717	0	p21/waf1/cip1	22,35	p53	89,92	p21/waf1/cip1	p53	1026	7157	Gene	Gene	induction|nmod|START_ENTITY independent|nsubj|induction independent|nmod|END_ENTITY	Early g1 induction of p21/waf1/cip1 in synchronized osteosarcoma cells is independent of p53 .
10602422	0	p210	170,174	BCR-ABL	68,75	p210	BCR-ABL	2125	25	Gene	Gene	clone|appos|START_ENTITY relapsing|nmod|clone transcripts|acl|relapsing END_ENTITY|dobj|transcripts	Pre-B acute_lymphoblastic_leukemia with b3a2 -LRB- p210 -RRB- and e1a2 -LRB- p190 -RRB- BCR-ABL fusion transcripts relapsing as chronic_myelogenous_leukemia with a less differentiated b3a2 -LRB- p210 -RRB- clone .
10602422	0	p210	46,50	BCR-ABL	68,75	p210	BCR-ABL	2125	25	Gene	Gene	b3a2|appos|START_ENTITY acute_lymphoblastic_leukemia|nmod|b3a2 END_ENTITY|nsubj|acute_lymphoblastic_leukemia	Pre-B acute_lymphoblastic_leukemia with b3a2 -LRB- p210 -RRB- and e1a2 -LRB- p190 -RRB- BCR-ABL fusion transcripts relapsing as chronic_myelogenous_leukemia with a less differentiated b3a2 -LRB- p210 -RRB- clone .
11964283	0	p210	14,18	BCR-ABL	19,26	p210	BCR-ABL	2125	25	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Modulation of p210 -LRB- BCR-ABL -RRB- activity in transduced primary human hematopoietic cells controls lineage programming .
12036931	0	p210	20,24	BCR-ABL	25,32	p210	BCR-ABL	2125	25	Gene	Gene	fusion|amod|START_ENTITY fusion|appos|END_ENTITY	Immunogenicity of a p210 -LRB- BCR-ABL -RRB- fusion domain candidate DNA vaccine targeted to dendritic cells by a recombinant adeno-associated virus vector in vitro .
14564482	0	p210	71,75	BCR-ABL	76,83	p210	BCR-ABL	2125	25	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Identification of new MHC-restriction elements for presentation of the p210 -LRB- BCR-ABL -RRB- fusion region to human cytotoxic T lymphocytes .
15458517	0	p210	120,124	BCR-ABL	111,118	p210	BCR-ABL	2125	25	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Acquired amegakaryocytic_thrombocytopenia associated with proliferation of gamma/delta TCR T-lymphocytes and a BCR-ABL -LRB- p210 -RRB- fusion transcript .
17315025	0	p210	0,4	BCR-ABL	5,12	p210	BCR-ABL	2125	25	Gene	Gene	reprograms|amod|START_ENTITY reprograms|appos|END_ENTITY	p210 -LRB- BCR-ABL -RRB- reprograms transformed and normal human megakaryocytic progenitor cells into erythroid cells and suppresses FLI-1 transcription .
18059481	0	p210	28,32	BCR-ABL	33,40	p210	BCR-ABL	2125	25	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Subcellular distribution of p210 -LRB- BCR-ABL -RRB- in CML cell lines and primary CD34 + CML cells .
9593785	0	p210	47,51	BCR-ABL	52,59	p210	BCR-ABL	2125	25	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic_myelogenous_leukemia .
10779439	0	p210	122,126	Bcr-Abl	127,134	p210	Bcr-Abl	14027(Tax:10090)	25	Gene	Gene	kinases|amod|START_ENTITY kinases|compound|END_ENTITY	Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases .
14506164	0	p210	10,14	Bcr-Abl	15,22	p210	Bcr-Abl	2125	25	Gene	Gene	Impact|nmod|START_ENTITY Impact|appos|END_ENTITY	Impact of p210 -LRB- Bcr-Abl -RRB- on ultraviolet C wavelength-induced DNA damage and repair .
9704934	0	p210	0,4	Bcr-Abl	5,12	p210	Bcr-Abl	2125	25	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic_myeloid_leukaemia .
15698792	0	p210	48,52	bcr-abl	53,60	p210	bcr-abl	2125	25	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Synthesis , structure-activity relationship , and p210 -LRB- bcr-abl -RRB- protein tyrosine kinase activity of novel AG_957 analogs .
9639422	0	p210	32,36	bcr-abl	37,44	p210	bcr-abl	2125	25	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Arginine_butyrate downregulates p210 bcr-abl expression and induces apoptosis in chronic_myelogenous_leukemia cells .
9672847	0	p210	97,101	bcr-abl	102,109	p210	bcr-abl	2125	25	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	CTLs specific for bcr-abl joining region segment peptides fail to lyse_leukemia cells expressing p210 bcr-abl protein .
9672847	0	p210	97,101	bcr-abl	18,25	p210	bcr-abl	2125	25	Gene	Gene	protein|amod|START_ENTITY expressing|dobj|protein cells|acl|expressing fail|nmod|cells fail|nsubj|specific specific|nmod|peptides peptides|amod|END_ENTITY	CTLs specific for bcr-abl joining region segment peptides fail to lyse_leukemia cells expressing p210 bcr-abl protein .
12545156	0	p21CIP1	38,45	Myc	0,3	p21CIP1	Myc	1026	4609	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter .
16170570	0	p21CIP1	122,129	cyclin_D1	162,171	p21CIP1	cyclin D1	1026	595	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	p53-independent G1 cell cycle arrest of human colon_carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin_D1 .
10920185	0	p21CIP1	41,48	transforming_growth_factor_beta	72,103	p21CIP1	transforming growth factor beta	1026	7040	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming_growth_factor_beta - induced cell-cycle arrest .
19935879	0	p21Cip1	103,110	cyclin_D1	60,69	p21Cip1	cyclin D1	1026	595	Gene	Gene	elevation|nmod|START_ENTITY concomitant|nmod|elevation concomitant|amod|END_ENTITY	Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin_D1 concomitant with an elevation in p21Cip1 in human cervical_carcinoma HeLa cells .
12973835	0	p21Cip1	66,73	p34Cdc2	128,135	p21Cip1	p34Cdc2	1026	983	Gene	Gene	up-regulation|compound|START_ENTITY up-regulation|nmod|END_ENTITY	ErbB2 overexpression in human breast_carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2 : poor responsiveness to chemotherapy with cyclophoshamide_methotrexate , and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression .
12847100	0	p21Cip1	82,89	retinoblastoma	112,126	p21Cip1	retinoblastoma	1026	5925	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein .
15475444	0	p21WAF1/CIP1	117,129	ARHI	40,44	p21WAF1/CIP1	ARHI	1026	9077	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of the tumor suppressor gene ARHI in epithelial_ovarian_cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival .
14761977	0	p21WAF1/CIP1	32,44	MDM2	0,4	p21WAF1/CIP1	MDM2	1026	4193	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	MDM2 is a negative regulator of p21WAF1/CIP1 , independent of p53 .
10203181	0	p21WAF1/CIP1	76,88	p53	128,131	p21WAF1/CIP1	p53	1026	7157	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Ultraviolet radiation down-regulates expression of the cell-cycle inhibitor p21WAF1/CIP1 in human cancer cells independently of p53 .
14761977	0	p21WAF1/CIP1	32,44	p53	61,64	p21WAF1/CIP1	p53	1026	7157	Gene	Gene	START_ENTITY|appos|independent independent|nmod|END_ENTITY	MDM2 is a negative regulator of p21WAF1/CIP1 , independent of p53 .
22190353	0	p21WAF1/CIP1	31,43	p53	20,23	p21WAF1/CIP1	p53	1026	7157	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death .
9072003	0	p21WAF1/CIP1	0,12	p53	157,160	p21WAF1/CIP1	p53	1026	7157	Gene	Gene	expression|amod|START_ENTITY associated|nsubj|expression associated|nmod|mutations mutations|compound|END_ENTITY	p21WAF1/CIP1 and MDM2 expression in non-Hodgkin 's _ lymphoma and their relationship to p53 status : a p53 + , MDM2 - , _ p21-immunophenotype associated with missense p53 mutations .
9926942	0	p21WAF1/CIP1	98,110	p53	56,59	p21WAF1/CIP1	p53	1026	7157	Gene	Gene	promoter|amod|START_ENTITY transcription|nmod|promoter transcription|compound|END_ENTITY	The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter .
10749849	0	p21WAF1/Cip1	111,123	p53	100,103	p21WAF1/Cip1	p53	1026	7157	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	The gut-enriched Kruppel-like factor -LRB- Kruppel-like factor 4 -RRB- mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter .
20701798	0	p21_CIP1	29,37	WAF1	38,42	p21 CIP1	WAF1	1026	1026	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	MiTF links Erk1/2 kinase and p21_CIP1 / WAF1 activation after UVC radiation in normal human melanocytes and melanoma cells .
10498616	0	p21_Ras	45,52	M-Ras	0,5	p21 Ras	M-Ras	3265	22808	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	M-Ras , a widely expressed 29-kD homologue of p21_Ras : expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line .
20526801	0	p21_activated_kinase-1	18,40	ERK	0,3	p21 activated kinase-1	ERK	5058	5594	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	ERK activation of p21_activated_kinase-1 -LRB- Pak1 -RRB- is critical for medulloblastoma cell migration .
18616527	0	p21cip1	118,125	cyclin_D1	33,42	p21cip1	cyclin D1	1026	595	Gene	Gene	factor|amod|START_ENTITY mediates|nmod|factor mediates|amod|END_ENTITY	Reactive oxygen species-mediated cyclin_D1 degradation mediates tumor_growth_retardation in hypoxia , independently of p21cip1 and hypoxia-inducible factor .
7594502	0	p21ras	0,6	Fc_epsilon_RI	13,26	p21ras	Fc epsilon RI	15461(Tax:10090)	14125(Tax:10090)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	p21ras links Fc_epsilon_RI to NF-AT family member in mast cells .
17311867	0	p21ras	37,43	H-ras	30,35	p21ras	H-ras	3265	3265	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Morphoproteomic expression of H-ras -LRB- p21ras -RRB- correlates with serum monoclonal immunoglobulin reduction in multiple_myeloma patients following pamidronate treatment .
9452363	0	p21ras	29,35	IFN-beta	39,47	p21ras	IFN-beta	3265	3456	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Dose-dependent activation of p21ras by IFN-beta .
1764245	0	p21ras	29,35	NGF	0,3	p21ras	NGF	293621(Tax:10116)	310738(Tax:10116)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	NGF and EGF rapidly activate p21ras in PC12 cells by distinct , convergent pathways involving tyrosine phosphorylation .
1608472	0	p21ras	15,21	extracellular_signal-regulated_kinase_2	39,78	p21ras	extracellular signal-regulated kinase 2	3265	5594	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p21ras in activation of extracellular_signal-regulated_kinase_2 .
8376929	0	p21ras	0,6	extracellular_signal-regulated_kinase_2	46,85	p21ras	extracellular signal-regulated kinase 2	3265	5594	Gene	Gene	couples|nsubj|START_ENTITY couples|nmod|lymphocytes lymphocytes|amod|END_ENTITY	p21ras couples the T_cell_antigen_receptor to extracellular_signal-regulated_kinase_2 in T lymphocytes .
8417322	0	p21ras	106,112	insulin	18,25	p21ras	insulin	3265	3630	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Ras activation by insulin and epidermal_growth_factor through enhanced exchange of guanine_nucleotides on p21ras .
27048108	0	p21ras	80,86	osteopontin	18,29	p21ras	osteopontin	3265	6696	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of osteopontin in breast_cancer tissue and its relationship with p21ras and CD44V6 expression .
14757171	0	p21waf1/cip1	98,110	ATM	63,66	p21waf1/cip1	ATM	1026	472	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Genistein arrests hepatoma cells at G2/M phase : involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1 .
21526487	0	p21waf1/cip1	72,84	p16INK4A	62,70	p21waf1/cip1	p16INK4A	1026	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Effect of human_papillomavirus on cell cycle-related proteins p16INK4A , p21waf1/cip1 , p53 and cyclin_D1 in sinonasal inverted_papilloma and laryngeal_carcinoma .
21526487	0	p21waf1/cip1	72,84	p53	86,89	p21waf1/cip1	p53	1026	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Effect of human_papillomavirus on cell cycle-related proteins p16INK4A , p21waf1/cip1 , p53 and cyclin_D1 in sinonasal inverted_papilloma and laryngeal_carcinoma .
24074410	0	p21waf1/cip1	36,48	p53	125,128	p21waf1/cip1	p53	1026	7157	Gene	Gene	upregulation|nmod|START_ENTITY enhancers|nsubj|upregulation enhancers|nmod|downmodulation downmodulation|nmod|END_ENTITY	EZH2-shRNA-mediated upregulation of p21waf1/cip1 and its transcriptional enhancers with concomitant downmodulation of mutant p53 in pancreatic_ductal_adenocarcinoma .
7995520	0	p21waf1/cip1	124,136	p53	42,45	p21waf1/cip1	p53	1026	7157	Gene	Gene	induce|dobj|START_ENTITY requires|xcomp|induce requires|dobj|END_ENTITY	Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1 .
8760300	0	p21waf1/cip1	29,41	p53	100,103	p21waf1/cip1	p53	114851(Tax:10116)	301300(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY loss|nmod|induction underlies|nsubj|loss underlies|dobj|defect defect|nmod|proteins proteins|compound|END_ENTITY	Selective loss of endogenous p21waf1/cip1 induction underlies the G1 checkpoint defect of monomeric p53 proteins .
9100069	0	p21waf1/cip1	47,59	p53	100,103	p21waf1/cip1	p53	1026	7157	Gene	Gene	induced|dobj|START_ENTITY p53|acl|induced Expression|nmod|p53 Expression|dep|correlation correlation|nmod|immunohistochemistry immunohistochemistry|compound|END_ENTITY	Expression of the p53 induced tumor suppressor p21waf1/cip1 in ovarian_carcinomas : correlation with p53 and Ki-67 immunohistochemistry .
9100069	0	p21waf1/cip1	47,59	p53	18,21	p21waf1/cip1	p53	1026	7157	Gene	Gene	induced|dobj|START_ENTITY END_ENTITY|acl|induced	Expression of the p53 induced tumor suppressor p21waf1/cip1 in ovarian_carcinomas : correlation with p53 and Ki-67 immunohistochemistry .
9861340	0	p21waf1/cip1	48,60	p53	123,126	p21waf1/cip1	p53	1026	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|relationship relationship|nmod|status status|compound|END_ENTITY	Expression of cyclin dependent kinase inhibitor p21waf1/cip1 in premalignant and malignant_oral_lesions : relationship with p53 status .
16788250	0	p22phox	33,40	CYBA	22,26	p22phox	CYBA	1535	1535	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	C242T polymorphism in CYBA gene -LRB- p22phox -RRB- and risk of coronary_artery_disease in a population of Caucasian Italians .
23755540	0	p22phox	60,67	CYBA	74,78	p22phox	CYBA	1535	1535	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Association between 242C _ > _ T polymorphism of NADPH oxidase p22phox gene -LRB- CYBA -RRB- and longevity in Russian population -RSB- .
24039708	0	p22phox	20,27	CYBA	29,33	p22phox	CYBA	1535	1535	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Relationship of the p22phox -LRB- CYBA -RRB- gene polymorphism C242T with risk of coronary_artery_disease : a meta-analysis .
24345348	0	p22phox	46,53	CYBA	60,64	p22phox	CYBA	1535	1535	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The A640G polymorphism in the NAD -LRB- P -RRB- H oxidase p22phox gene -LRB- CYBA -RRB- is associated with risk reduction of coronary_heart_disease : a meta-analysis .
15994299	0	p22phox	46,53	Nox1	81,85	p22phox	Nox1	1535	27035	Gene	Gene	region|nmod|START_ENTITY mutations|nmod|region inhibitors|nsubj|mutations inhibitors|nmod|generation generation|amod|END_ENTITY	Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1 - and Nox2-dependent reactive oxygen generation .
15477006	0	p22phox	36,43	nox1	26,30	p22phox	nox1	1535	27035	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Functional association of nox1 with p22phox in vascular smooth muscle cells .
12456498	0	p23	52,55	BCL3	25,29	p23	BCL3	10728	602	Gene	Gene	t|dep|START_ENTITY t|compound|END_ENTITY	High-level expression of BCL3 differentiates t -LRB- 2 ; 5 -RRB- -LRB- p23 ; q35 -RRB- - positive anaplastic_large_cell_lymphoma from Hodgkin_disease .
8225587	0	p23	45,48	OspC	50,54	p23	OspC	8851	13917590	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization and expression of p23 -LRB- OspC -RRB- from a North American strain of Borrelia_burgdorferi .
10376215	0	p23	44,47	Tmp21	37,42	p23	Tmp21	10972	10972	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A comparative study of rat and human Tmp21 -LRB- p23 -RRB- reveals the pseudogene-like features of human Tmp21-II .
9565682	0	p23	115,118	glycogen_synthase_kinase-3beta	43,73	p23	glycogen synthase kinase-3beta	8851	2932	Gene	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	Characterization of tau phosphorylation in glycogen_synthase_kinase-3beta and cyclin dependent kinase-5 activator -LRB- p23 -RRB- transfected cells .
19751963	0	p23	92,95	hTERT	101,106	p23	hTERT	10728	7015	Gene	Gene	dissociating|dobj|START_ENTITY dissociating|nmod|END_ENTITY	Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT .
7606740	0	p230	115,119	BCR/ABL	120,127	p230	BCR/ABL	2803	25	Gene	Gene	protein|nummod|START_ENTITY protein|amod|END_ENTITY	Establishment and molecular characterization of a novel leukemic cell line with Philadelphia chromosome expressing p230 BCR/ABL fusion protein .
16875837	0	p24	34,37	CD4	42,45	p24	CD4	10959	920	Gene	Gene	START_ENTITY|nmod|cell cell|compound|END_ENTITY	The antigenic determinants on HIV p24 for CD4 + T cell inhibiting antibodies as determined by limited proteolysis , chemical modification , and mass spectrometry .
25343245	0	p24	80,83	Gag	28,31	p24	Gag	10959	155030(Tax:11676)	Gene	Gene	Detection|compound|START_ENTITY Generation|nmod|Detection Generation|nmod|Panel Panel|compound|END_ENTITY	Generation of a Recombinant Gag Virus-Like-Particle Panel for the Evaluation of p24 Antigen Detection by Diagnostic HIV Tests .
8627263	0	p24	85,88	Gag	122,125	p24	Gag	10959	155030(Tax:11676)	Gene	Gene	antigen|amod|START_ENTITY domain|nmod|antigen interactions|nmod|domain essential|nsubj|interactions essential|nmod|assembly assembly|compound|END_ENTITY	Gag-Gag interactions in the C-terminal domain of human_immunodeficiency_virus_type_1 p24 capsid antigen are essential for Gag particle assembly .
22829115	0	p24	14,17	gag	18,21	p24	gag	10959	2760846(Tax:11901)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Expression of p24 gag protein of bovine_leukemia_virus in insect cells and its use in immunodetection of the disease .
23015721	0	p24	49,52	gag	53,56	p24	gag	10959	155030(Tax:11676)	Gene	Gene	mutation|amod|START_ENTITY mutation|compound|END_ENTITY	Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness .
2787798	0	p24	84,87	gag	71,74	p24	gag	10959	1491934(Tax:11908)	Gene	Gene	proteins|nummod|START_ENTITY END_ENTITY|dobj|proteins	Frequent lack of antibodies against human_T-cell_leukemia_virus_type_I gag proteins p24 or p19 in sera of patients with adult_T-cell_leukemia .
1677177	0	p24	55,58	interleukin_1-beta	35,53	p24	interleukin 1-beta	10959	3553	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Serum tumor_necrosis_factor alpha , interleukin_1-beta , p24 antigen concentrations and CD4 + cells at various stages of human_immunodeficiency_virus_1_infection in children .
24555933	0	p24	39,42	scFv	26,30	p24	scFv	13088(Tax:10090)	652070	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of recombinant scFv against p24 of human_immunodeficiency_virus_type_1 by phage display technology .
17121855	0	p25	71,74	CDK5	49,53	p25	CDK5	170496(Tax:10116)	140908(Tax:10116)	Gene	Gene	p35|nmod|START_ENTITY p35|nsubj|Suppression Suppression|nmod|cleavage cleavage|nmod|activator activator|compound|END_ENTITY	Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation .
21338355	0	p25	106,109	Calpastatin	0,11	p25	Calpastatin	12569(Tax:10090)	12380(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Calpastatin , an endogenous calpain-inhibitor protein , regulates the cleavage of the Cdk5 activator p35 to p25 .
10604467	0	p25	21,24	Cdk5	37,41	p25	Cdk5	8851	1020	Gene	Gene	Conversion|nmod|START_ENTITY deregulates|nsubj|Conversion deregulates|dobj|activity activity|amod|END_ENTITY	Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration .
14642273	0	p25	28,31	Cdk5	9,13	p25	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary_tangles .
21338355	0	p25	106,109	Cdk5	84,88	p25	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|cleavage cleavage|nmod|p35 p35|amod|END_ENTITY	Calpastatin , an endogenous calpain-inhibitor protein , regulates the cleavage of the Cdk5 activator p35 to p25 .
25331900	0	p25	23,26	GSK3b	62,67	p25	GSK3b	8851	2932	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	CDK5 activator protein p25 preferentially binds and activates GSK3b .
26045498	0	p25	51,54	GSK3b	90,95	p25	GSK3b	8851	2932	Gene	Gene	Correction|nmod|START_ENTITY binds|nsubj|Correction binds|dobj|END_ENTITY	Correction for Chow et al. , CDK5 activator protein p25 preferentially binds and activates GSK3b .
9155744	0	p25	47,50	StAR	32,36	p25	StAR	170496(Tax:10116)	25557(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Steroidogenic acute regulatory -LRB- StAR -RRB- protein -LRB- p25 -RRB- and prohibitin -LRB- p28 -RRB- from cultured rat ovarian granulosa cells .
10706614	0	p25	100,103	cdk5	121,125	p25	cdk5	8851	1020	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25 , an activator of cdk5 .
10903889	0	p25	56,59	cdk5	14,18	p25	cdk5	170496(Tax:10116)	140908(Tax:10116)	Gene	Gene	form|appos|START_ENTITY p35|nmod|form p35|nsubj|Processing Processing|nmod|activator activator|amod|END_ENTITY	Processing of cdk5 activator p35 to its truncated form -LRB- p25 -RRB- by calpain in acutely injured neuronal cells .
22537847	0	p25	114,117	cdk5	18,22	p25	cdk5	170496(Tax:10116)	140908(Tax:10116)	Gene	Gene	upregulation|nmod|START_ENTITY leads|nmod|upregulation leads|nsubj|Crosstalk Crosstalk|nmod|END_ENTITY	Crosstalk between cdk5 and MEK-ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain .
22889803	0	p25	136,139	cdk5	130,134	p25	cdk5	8851	1020	Gene	Gene	inhibitors|nummod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and structure-activity relationship of 4 - -LRB- 1,3-benzothiazol-2-yl -RRB- - thiophene-2-sulfonamides as cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- / p25 inhibitors .
20033852	0	p25	14,17	cyclin-dependent_kinase_5	31,56	p25	cyclin-dependent kinase 5	170496(Tax:10116)	140908(Tax:10116)	Gene	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	Expression of p25 , an aberrant cyclin-dependent_kinase_5 activator , stimulates basal secretion in PC12 cells .
1376136	0	p25	96,99	gag	92,95	p25	gag	15507(Tax:10090)	17276(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	HIV-1 env , nef , and gag-specific T-cell immunity in mice : conserved epitopes in nef p27 and gag p25 proteins .
8384302	0	p25	59,62	rab3A	53,58	p25	rab3A	280968(Tax:9913)	282029(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Rabphilin-3A , a putative target protein for smg_p25A / rab3A p25 small GTP-binding protein related to synaptotagmin .
8384302	0	p25	59,62	smg_p25A	44,52	p25	smg p25A	280968(Tax:9913)	282029(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Rabphilin-3A , a putative target protein for smg_p25A / rab3A p25 small GTP-binding protein related to synaptotagmin .
8450888	0	p250	4,8	TFIID	51,56	p250	TFIID	6872	6908	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1 .
18331582	0	p250GAP	103,110	Rho	72,75	p250GAP	Rho	9743	6010	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein , p250GAP .
12788081	0	p250GAP	0,7	RhoGAP	18,24	p250GAP	RhoGAP	9743	392	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	p250GAP , a neural RhoGAP protein , is associated with and phosphorylated by Fyn .
18710468	0	p27	14,17	AIP	108,111	p27	AIP	10671	9049	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Assessment of p27 -LRB- cyclin-dependent kinase inhibitor 1B -RRB- and aryl_hydrocarbon_receptor-interacting_protein -LRB- AIP -RRB- genes in multiple_endocrine_neoplasia _ -LRB- MEN1 -RRB- _ syndrome patients without any detectable MEN1 gene mutations .
22139837	0	p27	27,30	Androgen_Receptor	0,17	p27	Androgen Receptor	10671	367	Gene	Gene	Degradation|compound|START_ENTITY Degradation|compound|END_ENTITY	Androgen_Receptor Enhances p27 Degradation in Prostate_Cancer Cells through Rapid and Selective TORC2 Activation .
11466560	0	p27	23,26	Angiotensin_II	0,14	p27	Angiotensin II	83571(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces p27 -LRB- Kip1 -RRB- expression in renal tubules in vivo : role of reactive oxygen species .
12082635	0	p27	59,62	BRCA1	0,5	p27	BRCA1	3429	672	Gene	Gene	transactivates|dobj|START_ENTITY transactivates|nsubj|END_ENTITY	BRCA1 transactivates the cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- .
10848600	0	p27	39,42	Bcl-2	0,5	p27	Bcl-2	10671	596	Gene	Gene	Kip1|amod|START_ENTITY retards|nmod|Kip1 retards|nsubj|END_ENTITY	Bcl-2 retards cell cycle entry through p27 -LRB- Kip1 -RRB- , pRB relative p130 , and altered E2F regulation .
16839413	0	p27	44,47	Bcl-2	0,5	p27	Bcl-2	3429	596	Gene	Gene	expressions|amod|START_ENTITY associated|nmod|expressions associated|nsubjpass|expression expression|amod|END_ENTITY	Bcl-2 protein expression is associated with p27 and p53 protein expressions and MIB-1 counts in breast_cancer .
18382684	0	p27	0,3	Bcl-2	31,36	p27	Bcl-2	12576(Tax:10090)	12043(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY cooperates|nsubj|deficiency cooperates|nmod|END_ENTITY	p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell_lymphoma .
19447221	0	p27	69,72	Bcl-2	0,5	p27	Bcl-2	10671	596	Gene	Gene	induced|nmod|START_ENTITY blocks|acl|induced blocks|nummod|END_ENTITY	Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27 -LRB- Kip1 -RRB- - dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation .
9894613	0	p27	139,142	Bcl-2	48,53	p27	Bcl-2	3429	596	Gene	Gene	kinase|dobj|START_ENTITY overcome|dep|kinase overcome|dobj|function function|amod|END_ENTITY	Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed , but not normal , human fibroblasts .
10490638	0	p27	66,69	CDK4	23,27	p27	CDK4	12576(Tax:10090)	12567(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY disruption|nmod|activity disruption|nmod|entry entry|nummod|END_ENTITY	Targeted disruption of CDK4 delays cell cycle entry with enhanced p27 -LRB- Kip1 -RRB- activity .
12781329	0	p27	181,184	CDK4	116,120	p27	CDK4	3429	1019	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|activities activities|amod|pentagalloylglucose pentagalloylglucose|nmod|down-regulation down-regulation|nmod|END_ENTITY	Induction of G1 phase arrest in MCF human breast_cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27 -LRB- Kip -RRB- and p21 -LRB- Cip -RRB- .
19574837	0	p27	60,63	CRM1	14,18	p27	CRM1	10534	7514	Gene	Gene	expression|amod|START_ENTITY Expression|nmod|expression Expression|nmod|END_ENTITY	Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis .
16467204	0	p27	14,17	Cul4A	0,5	p27	Cul4A	22428(Tax:10090)	99375(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Cul4A targets p27 for degradation and regulates proliferation , cell cycle exit , and differentiation during erythropoiesis .
11969263	0	p27	98,101	Cux-1	44,49	p27	Cux-1	12576(Tax:10090)	13047(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|expression expression|nmod|END_ENTITY	Deregulated expression of the homeobox gene Cux-1 in transgenic_mice results in downregulation of p27 -LRB- kip1 -RRB- expression during nephrogenesis , glomerular_abnormalities , and multiorgan hyperplasia .
21465620	0	p27	54,57	Cux1	22,26	p27	Cux1	12576(Tax:10090)	13047(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|nmod|END_ENTITY	Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts .
26481195	0	p27	79,82	Cx43	15,19	p27	Cx43	3429	2697	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of Cx43 with Hsc70 regulates G1/S transition through CDK inhibitor p27 .
26344141	0	p27	67,70	Cyclin-Dependent_Kinase_Inhibitor_1B	29,65	p27	Cyclin-Dependent Kinase Inhibitor 1B	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	SGK1-Sensitive Regulation of Cyclin-Dependent_Kinase_Inhibitor_1B -LRB- p27 -RRB- in Cardiomyocyte Hypertrophy .
15557231	0	p27	67,70	Cyclin_A	0,8	p27	Cyclin A	3429	890	Gene	Gene	deregulation|amod|START_ENTITY uncoupled|nmod|deregulation uncoupled|nsubjpass|expression expression|compound|END_ENTITY	Cyclin_A expression and growth in suspension can be uncoupled from p27 deregulation and extracellular signal-regulated kinase activity in cells transformed by bovine_papillomavirus_type_4 E5 .
11590147	0	p27	91,94	Cyclin_D1	0,9	p27	Cyclin D1	10671	595	Gene	Gene	association|amod|START_ENTITY induces|nmod|association induces|nsubj|overexpression overexpression|amod|END_ENTITY	Cyclin_D1 overexpression induces progestin resistance in T-47D breast_cancer cells despite p27 -LRB- Kip1 -RRB- association with cyclin E-Cdk2 .
17047061	0	p27	51,54	Cyclin_D1	0,9	p27	Cyclin D1	3429	595	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|induction induction|amod|END_ENTITY	Cyclin_D1 induction of cellular migration requires p27 -LRB- KIP1 -RRB- .
20837141	0	p27	20,23	Cyclin_D1	0,9	p27	Cyclin D1	10671	595	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Cyclin_D1 regulates p27 -LRB- Kip1 -RRB- stability in B cells .
16998811	0	p27	72,75	EZH2	49,53	p27	EZH2	3429	2146	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
12833139	0	p27	66,69	Gadd45alpha	8,19	p27	Gadd45alpha	12576(Tax:10090)	13197(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	Role of Gadd45alpha in the density-dependent G1 arrest induced by p27 -LRB- Kip1 -RRB- .
21715331	0	p27	52,55	Homeodomain-interacting_protein_kinase-2	0,40	p27	Homeodomain-interacting protein kinase-2	3429	28996	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Homeodomain-interacting_protein_kinase-2 stabilizes p27 -LRB- kip1 -RRB- by its phosphorylation at serine 10 and contributes to cell motility .
16998811	0	p27	72,75	INK4A	64,69	p27	INK4A	3429	1029	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
20683015	0	p27	14,17	INK4a	42,47	p27	INK4a	3429	1029	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of p27 , p21 -LRB- WAF/Cip1 -RRB- , and p16 -LRB- INK4a -RRB- in normal oral epithelium , oral_squamous_papilloma , and oral_squamous_cell_carcinoma .
15930262	0	p27	33,36	JAB1	67,71	p27	JAB1	3429	10987	Gene	Gene	stability|amod|START_ENTITY stability|nmod|END_ENTITY	Tumor suppressor VDUP1 increases p27 -LRB- kip1 -RRB- stability by inhibiting JAB1 .
20698225	0	p27	57,60	JAB1	0,4	p27	JAB1	3429	10987	Gene	Gene	kip1|amod|START_ENTITY expression|nmod|kip1 associated|nmod|expression associated|nsubjpass|expression expression|compound|END_ENTITY	JAB1 expression is associated with inverse expression of p27 -LRB- kip1 -RRB- in hepatocellular_carcinoma .
11751512	0	p27	57,60	Jab1	0,4	p27	Jab1	3429	10987	Gene	Gene	kip1|amod|START_ENTITY expression|nmod|kip1 associated|nmod|expression associated|nsubjpass|expression expression|amod|END_ENTITY	Jab1 expression is associated with inverse expression of p27 -LRB- kip1 -RRB- and poor prognosis in epithelial_ovarian_tumors .
16300740	0	p27	78,81	Jab1	42,46	p27	Jab1	10671	10987	Gene	Gene	translocation|nummod|START_ENTITY required|nmod|translocation required|nsubjpass|Interaction Interaction|nmod|p8 p8|nmod|END_ENTITY	Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation .
24170542	0	p27	32,35	Jab1	90,94	p27	Jab1	10534	10987	Gene	Gene	accumulation|amod|START_ENTITY accumulation|nmod|down-regulation down-regulation|nmod|END_ENTITY	Adhesion to fibronectin induces p27 -LRB- Kip1 -RRB- nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance -LRB- CAM-DR -RRB- in RPMI 8,226 cells .
24344238	0	p27	69,72	Jab1	0,4	p27	Jab1	12576(Tax:10090)	26754(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Jab1 regulates Schwann cell proliferation and axonal sorting through p27 .
24949832	0	p27	60,63	Jab1	86,90	p27	Jab1	10671	3725	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1 .
12782606	0	p27	119,122	Jun_activation_domain-binding_protein_1	0,39	p27	Jun activation domain-binding protein 1	3429	10987	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|amod|END_ENTITY	Jun_activation_domain-binding_protein_1 expression in breast_cancer inversely correlates with the cell cycle inhibitor p27 -LRB- Kip1 -RRB- .
16721818	0	p27	111,114	Jun_activation_domain-binding_protein_1	18,57	p27	Jun activation domain-binding protein 1	10534	10987	Gene	Gene	expression|amod|START_ENTITY Overexpression|nmod|expression Overexpression|nmod|END_ENTITY	Overexpression of Jun_activation_domain-binding_protein_1 in nonsmall_cell_lung_cancer and its significance in p27 expression and clinical features .
19139918	0	p27	79,82	Jun_activation_domain-binding_protein_1	14,53	p27	Jun activation domain-binding protein 1	10671	10987	Gene	Gene	protein|amod|START_ENTITY phosphorylated|dobj|protein phosphorylated|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Jun_activation_domain-binding_protein_1 and Ser10 phosphorylated p27 protein in human epithelial_ovarian_carcinoma .
21837501	0	p27	77,80	Jun_activation_domain-binding_protein_1	18,57	p27	Jun activation domain-binding protein 1	3429	10987	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Potential role of Jun_activation_domain-binding_protein_1 and phosphorylated p27 expression in prognosis of glioma .
22311264	0	p27	135,138	Jun_activation_domain-binding_protein_1	0,39	p27	Jun activation domain-binding protein 1	3429	10987	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|amod|END_ENTITY	Jun_activation_domain-binding_protein_1 expression in oral_squamous_cell_carcinomas inversely correlates with the cell cycle inhibitor p27 .
10454569	0	p27	82,85	KIP1	86,90	p27	KIP1	3429	1027	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Elevated cyclin E levels , inactive retinoblastoma protein , and suppression of the p27 -LRB- KIP1 -RRB- inhibitor characterize early development of promyeloid cells into macrophages .
10469613	0	p27	40,43	KIP1	44,48	p27	KIP1	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of the CDK inhibitor p27 -LRB- KIP1 -RRB- in rat two-stage bladder_carcinogenesis and its association with expression profiles of p21 -LRB- WAF1/Cip1 -RRB- and p53 .
10469613	4	p27	749,752	KIP1	753,757	p27	KIP1	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	In a rat two-stage urinary_bladder_carcinogenesis model , with N-butyl-N - -LRB- 4-hydroxybutyl -RRB- nitrosamine -LRB- BBN -RRB- initiation followed by promotion with sodium_L-ascorbate -LRB- Na-AsA -RRB- , we evaluated the expression of p27 -LRB- KIP1 -RRB- protein using immunohistochemistry during various stages of urinary_bladder_carcinogenesis .
10702262	0	p27	127,130	KIP1	131,135	p27	KIP1	3429	1027	Gene	Gene	independent|amod|START_ENTITY independent|appos|END_ENTITY	Reversible G -LRB- 1 -RRB- arrest induced by inhibition of the epidermal_growth_factor_receptor tyrosine kinase requires up-regulation of p27 -LRB- KIP1 -RRB- independent of MAPK activity .
10704940	0	p27	40,43	KIP1	44,48	p27	KIP1	3429	1027	Gene	Gene	increase|amod|START_ENTITY increase|appos|END_ENTITY	Induction of G -LRB- 1 -RRB- cell cycle arrest and p27 -LRB- KIP1 -RRB- increase by panaxydol isolated from Panax_ginseng .
10705242	0	p27	8,11	KIP1	12,16	p27	KIP1	10534	1027	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of p27 -LRB- KIP1 -RRB- expression predicts poor prognosis in patients with esophageal_squamous_cell_carcinoma .
11093779	0	p27	13,16	KIP1	17,21	p27	KIP1	10671	1027	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of p27 -LRB- KIP1 -RRB- as a mechanism underlying NS398-induced growth inhibition in human lung_cancer cells .
11093779	11	p27	1594,1597	KIP1	1598,1602	p27	KIP1	10671	1027	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Metabolic labeling experiments showed that the synthesis rate of p27 -LRB- KIP1 -RRB- protein was not altered by NS398 .
11141482	0	p27	23,26	KIP1	27,31	p27	KIP1	10671	1027	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	Protective function of p27 -LRB- KIP1 -RRB- against apoptosis in small_cell_lung_cancer cells in unfavorable microenvironments .
11340156	0	p27	16,19	KIP1	20,24	p27	KIP1	10671	1027	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|appos|END_ENTITY	Requirement for p27 -LRB- KIP1 -RRB- in retinoblastoma protein-mediated senescence .
11819639	0	p27	18,21	KIP1	22,26	p27	KIP1	3429	1027	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of p27 -LRB- KIP1 -RRB- induced cell cycle arrest in G -LRB- 1 -RRB- phase and subsequent apoptosis in HCC-9204 cell line .
12429803	0	p27	146,149	KIP1	150,154	p27	KIP1	10671	1027	Gene	Gene	down-regulation|compound|START_ENTITY down-regulation|appos|END_ENTITY	Over-expression of p45 -LRB- SKP2 -RRB- in Kaposi 's _ sarcoma correlates with higher_tumor stage and extracutaneous involvement but is not directly related to p27 -LRB- KIP1 -RRB- down-regulation .
12586749	4	p27	821,824	KIP1	825,829	p45	SKP2	6502	6502	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Here , we show that treatment of AT-84 head and neck squamous_carcinoma cells with the 1,25 -LRB- OH -RRB- -LRB- 2 -RRB- D -LRB- 3 -RRB- analog EB1089 increases p27 -LRB- KIP1 -RRB- protein levels without significantly affecting expression of its mRNA .
15007644	0	p27	15,18	KIP1	19,23	p27	KIP1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of p27 -LRB- KIP1 -RRB- in proliferation of the retinal pigment epithelium and ciliary body .
16407831	0	p27	86,89	KIP1	90,94	p27	KIP1	3429	1027	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27 -LRB- KIP1 -RRB- protein .
16437650	0	p27	10,13	KIP1	14,18	p27	KIP1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of p27 -LRB- KIP1 -RRB- on cell cycle and apoptosis in gastric_cancer cells .
16603463	0	p27	19,22	KIP1	23,27	p27	KIP1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of p27 -LRB- KIP1 -RRB- in the mitotic cells of the corneal epithelium .
17854759	0	p27	56,59	KIP1	60,64	p27	KIP1	10671	1027	Gene	Gene	cleaves|dobj|START_ENTITY activity|acl:relcl|cleaves activity|appos|END_ENTITY	Cell cycle-dependent caspase-like activity that cleaves p27 -LRB- KIP1 -RRB- is the beta -LRB- 1 -RRB- subunit of the 20S proteasome .
20728136	0	p27	34,37	KIP1	38,42	p27	KIP1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The physiological significance of p27 -LRB- KIP1 -RRB- expression in detrusor function .
21553651	0	p27	79,82	KIP1	83,87	p27	KIP1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	PDE4 inhibitor suppresses PGE2-induced osteoclast formation via COX-2-mediated p27 -LRB- KIP1 -RRB- expression in RAW264 .7 cells .
22372491	0	p27	42,45	KIP1	46,50	p27	KIP1	10671	1027	Gene	Gene	stabilization|amod|START_ENTITY stabilization|appos|END_ENTITY	Prodigiosin down-regulates SKP2 to induce p27 -LRB- KIP1 -RRB- stabilization and antiproliferation in human lung_adenocarcinoma cells .
22584582	0	p27	30,33	KIP1	34,38	p27	KIP1	10671	1027	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Successive phosphorylation of p27 -LRB- KIP1 -RRB- protein at serine-10 and C terminus crucially controls its potency to inactivate Cdk2 .
26687548	0	p27	50,53	KIP1	55,59	p27	KIP1	10671	1027	Gene	Gene	translation|amod|START_ENTITY translation|appos|END_ENTITY	NSun2 delays replicative senescence by repressing p27 -LRB- KIP1 -RRB- translation and elevating CDK1 translation .
17874532	0	p27	9,12	KIP_1	14,19	p27	KIP 1	10534	1027	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	-LSB- Role of p27 -LRB- KIP_1 -RRB- in regulation of retinal cell proliferation -RSB- .
10318797	0	p27	19,22	Kip1	23,27	p27	Kip1	10671	1027	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of p27 -LRB- Kip1 -RRB- by two mechanisms , ubiquitin-mediated degradation and proteolytic processing .
10361114	0	p27	38,41	Kip1	42,46	p27	Kip1	10534	1027	Gene	Gene	cyclin-dependent|amod|START_ENTITY cyclin-dependent|appos|END_ENTITY	Expression of p21 -LRB- Cip1/Waf1/Sdi1 -RRB- and p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitors during human hematopoiesis .
10375532	0	p27	0,3	Kip1	4,8	p27	Kip1	10671	1027	Gene	Gene	ubiquitination|amod|START_ENTITY ubiquitination|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
10375532	0	p27	112,115	Kip1	4,8	p27	Kip1	10671	1027	Gene	Gene	Thr187|nmod|START_ENTITY complex|nmod|Thr187 regulated|nmod|complex regulated|nsubjpass|ubiquitination ubiquitination|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
10398135	0	p27	27,30	Kip1	31,35	p27	Kip1	3429	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of p27 -LRB- Kip1 -RRB- expression in colorectal_cancer : a clinico-pathological characterization .
10490638	0	p27	66,69	Kip1	70,74	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Targeted disruption of CDK4 delays cell cycle entry with enhanced p27 -LRB- Kip1 -RRB- activity .
10491517	0	p27	22,25	Kip1	26,30	p27	Kip1	10671	1027	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Reduced expression of p27 -LRB- Kip1 -RRB- protein in relation to salivary adenoid cystic carcinoma metastasis .
10534337	0	p27	10,13	Kip1	14,18	p27	Kip1	3429	1027	Gene	Gene	influence|nsubj|START_ENTITY influence|dep|END_ENTITY	Decreased p27 -LRB- Kip1 -RRB- expression and cyclin_D1 overexpression , alone and in combination , influence recurrence and survival of patients with resectable extrahepatic_bile_duct_carcinoma .
10542271	0	p27	71,74	Kip1	75,79	p27	Kip1	3429	1027	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Sp1 and NF-Y synergistically mediate the effect of vitamin_D -LRB- 3 -RRB- in the p27 -LRB- Kip1 -RRB- gene promoter that lacks vitamin_D response elements .
10662779	0	p27	27,30	Kip1	31,35	p27	Kip1	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differential regulation of p27 -LRB- Kip1 -RRB- expression by mitogenic and hypertrophic factors : Involvement of transcriptional and posttranscriptional mechanisms .
10694472	0	p27	24,27	Kip1	28,32	p27	Kip1	10671	1027	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Activation of the human p27 -LRB- Kip1 -RRB- promoter by IFNalpha 2b .
10704741	0	p27	34,37	Kip1	38,42	p27	Kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- expression in transitional cell carcinoma_of_renal_pelvis_and_ureter .
10796881	0	p27	0,3	Kip1	4,8	p27	Kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- expression in normal epithelia , precancerous_lesions , and carcinomas of the gallbladder : association with cancer progression and prognosis .
10888749	0	p27	34,37	Kip1	38,42	p27	Kip1	10671	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- expression in thyroid cells obtained by fine-needle aspiration biopsy : a preliminary report .
10942583	0	p27	26,29	Kip1	30,34	p27	Kip1	10671	1027	Gene	Gene	form|nmod|START_ENTITY Accumulation|nmod|form Accumulation|appos|END_ENTITY	Accumulation of a form of p27 -LRB- Kip1 -RRB- not associated with Cdk-cyclin complexes in transforming_growth_factor-beta-arrested Mv1Lu cells .
10942583	1	p27	312,315	Kip1	316,320	p27	Kip1	10671	1027	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor translocates in response to transforming_growth_factor-beta to a Cdk2-cyclin E complex inhibiting its catalytic activity , but the p27 -LRB- Kip1 -RRB- protein levels are unaffected -LSB- 1 -RSB- .
11080613	0	p27	25,28	Kip1	29,33	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Changes in p21 -LRB- Cip1 -RRB- and p27 -LRB- Kip1 -RRB- expression are not required for cell cycle entry and progression to S phase in Swiss_3T3 cells .
11159883	0	p27	8,11	Kip1	12,16	p27	Kip1	10671	1027	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of p27 -LRB- Kip1 -RRB- in human intestinal cell differentiation .
11160939	0	p27	72,75	Kip1	76,80	p27	Kip1	10534	100689401	Gene	Gene	sense|amod|START_ENTITY sense|appos|END_ENTITY	Streptogramin - and tetracycline-responsive dual regulated expression of p27 -LRB- Kip1 -RRB- sense and antisense enables positive and negative growth control of Chinese_hamster_ovary cells .
11266285	0	p27	28,31	Kip1	32,36	p27	Kip1	10534	1027	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Anomalous overexpression of p27 -LRB- Kip1 -RRB- in sporadic_pancreatic_endocrine_tumors .
11313917	0	p27	35,38	Kip1	39,43	p27	Kip1	10534	1027	Gene	Gene	cyclin-dependent|amod|START_ENTITY cyclin-dependent|appos|END_ENTITY	Repression of transcription of the p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor gene by c-Myc .
11353044	0	p27	14,17	Kip1	18,22	p27	Kip1	3429	1027	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of p27 -LRB- Kip1 -RRB- protein in transitional cell carcinoma of the upper urinary tract .
11400230	0	p27	18,21	Kip1	22,26	p27	Kip1	10671	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Low expression of p27 -LRB- Kip1 -RRB- in advanced mucoepidermoid_carcinomas of head and neck .
11400230	9	p27	1563,1566	Kip1	1567,1571	p27	Kip1	10671	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Also patients with low p27 -LRB- Kip1 -RRB- expression showed poor prognosis -LRB- p = .002 -RRB- .
11413088	0	p27	9,12	Kip1	13,17	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role for p27 -LRB- Kip1 -RRB- in Vascular Smooth Muscle Cell Migration .
11466560	0	p27	23,26	Kip1	27,31	p27	Kip1	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II induces p27 -LRB- Kip1 -RRB- expression in renal tubules in vivo : role of reactive oxygen species .
11527971	0	p27	42,45	Kip1	46,50	p27	Kip1	10671	1027	Gene	Gene	deregulation|amod|START_ENTITY deregulation|appos|END_ENTITY	Constitutive MEK/MAPK activation leads to p27 -LRB- Kip1 -RRB- deregulation and antiestrogen resistance in human breast_cancer cells .
11557117	0	p27	43,46	Kip1	47,51	p27	Kip1	10534	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of cell-cycle regulator p27 -LRB- Kip1 -RRB- correlates with a shortened survival in non-small_cell_lung_cancer .
11557735	0	p27	98,101	Kip1	102,106	p27	Kip1	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27 -LRB- Kip1 -RRB- expression in the vasculature of hypertensive rats .
11579684	0	p27	32,35	Kip1	37,41	p27	Kip1	3429	1027	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of p27 -LRB- Kip1 -RRB- in human pituitary glands and in various types of pituitary_adenomas .
11590147	0	p27	91,94	Kip1	95,99	p27	Kip1	10671	1027	Gene	Gene	association|amod|START_ENTITY association|appos|END_ENTITY	Cyclin_D1 overexpression induces progestin resistance in T-47D breast_cancer cells despite p27 -LRB- Kip1 -RRB- association with cyclin E-Cdk2 .
11716548	0	p27	33,36	Kip1	37,41	p27	Kip1	10534	1027	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Transcriptional up-regulation of p27 -LRB- Kip1 -RRB- during contact-induced growth_arrest in vascular endothelial cells .
11753978	0	p27	39,42	Kip1	43,47	p27	Kip1	10671	1027	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the cell cycle regulator p27 -LRB- Kip1 -RRB- in normal squamous epithelium , cervical_intraepithelial_neoplasia , and invasive squamous_cell_carcinoma_of_the_uterine_cervix .
11854065	0	p27	19,22	Kip1	23,27	p27	Kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic role of p27 -LRB- Kip1 -RRB- expression in oral_squamous_cell_carcinoma in Taiwan .
12146978	0	p27	18,21	Kip1	22,26	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	ACTH promotion of p27 -LRB- Kip1 -RRB- induction in mouse Y1 adrenocortical_tumor cells is dependent on both PKA activation and Akt/PKB inactivation .
12149143	0	p27	34,37	Kip1	38,42	p27	Kip1	10534	1027	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Troglitazone induces G1_arrest by p27 -LRB- Kip1 -RRB- induction that is mediated by inhibition of proteasome in human gastric_cancer cells .
12351407	0	p27	22,25	Kip1	26,30	p27	Kip1	10671	1027	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	p27	22,25	Kip1	94,98	p27	Kip1	10671	1027	Gene	Gene	ligase|amod|START_ENTITY Expression|appos|ligase Expression|dep|correlation correlation|nmod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	p27	90,93	Kip1	26,30	p27	Kip1	10671	1027	Gene	Gene	Kip1|amod|START_ENTITY correlation|nmod|Kip1 Expression|dep|correlation Expression|appos|ligase ligase|appos|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12451619	0	p27	13,16	Kip1	17,21	p27	Kip1	10534	1027	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Low level of p27 -LRB- Kip1 -RRB- protein expression in gastric_adenocarcinoma is associated with disease progression and poor outcome .
12700629	0	p27	10,13	Kip1	14,18	p27	Kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Inducible p27 -LRB- Kip1 -RRB- expression inhibits proliferation of K562 cells and protects against apoptosis induction by proteasome inhibitors .
12776284	0	p27	39,42	Kip1	43,47	p27	Kip1	3429	1027	Gene	Gene	cyclin-dependent|amod|START_ENTITY cyclin-dependent|appos|END_ENTITY	Increased expression of p16 -LRB- INK4a -RRB- and p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor genes in aging human kidney and chronic_allograft_nephropathy .
14654548	0	p27	74,77	Kip1	78,82	p27	Kip1	3429	1027	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Jun_activation_domain_binding_protein_1 expression is associated with low p27 -LRB- Kip1 -RRB- levels in node-negative breast_cancer .
14977358	0	p27	14,17	Kip1	18,22	p27	Kip1	10671	1027	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of p27 -LRB- Kip1 -RRB- by intracellular iron levels .
15075339	0	p27	0,3	Kip1	4,8	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	stabilization|amod|START_ENTITY stabilization|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- stabilization and G -LRB- 1 -RRB- arrest by 1,25-dihydroxyvitamin _ D -LRB- 3 -RRB- in ovarian_cancer cells mediated through down-regulation of cyclin E/cyclin-dependent _ kinase_2 and Skp1-Cullin-F-box protein/Skp2 ubiquitin ligase .
15110991	0	p27	12,15	Kip1	16,20	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of p27 -LRB- Kip1 -RRB- in maintaining the levels of D-type cyclins in vivo .
15176022	0	p27	0,3	Kip1	4,8	p27	Kip1	10671	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- expression and grading of breast_cancer diagnosed on cytological samples .
15568022	0	p27	14,17	Kip1	18,22	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Protection of p27 -LRB- Kip1 -RRB- mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation .
16135812	0	p27	68,71	Kip1	72,76	p27	Kip1	10534	1027	Gene	Gene	mislocalization|amod|START_ENTITY mislocalization|appos|END_ENTITY	Pathway - and expression level-dependent effects of oncogenic N-Ras : p27 -LRB- Kip1 -RRB- mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling .
16359379	0	p27	137,140	Kip1	141,145	p27	Kip1	3429	1027	Gene	Gene	cyclin-dependent|amod|START_ENTITY cyclin-dependent|appos|END_ENTITY	Up-regulation of cell cycle regulatory genes after renal_ischemia / reperfusion : differential expression of p16 -LRB- INK4a -RRB- , p21 -LRB- WAF1/CIP1 -RRB- and p27 -LRB- Kip1 -RRB- cyclin-dependent kinase inhibitor genes depending on reperfusion time .
16489017	0	p27	23,26	Kip1	27,31	p27	Kip1	10534	1027	Gene	Gene	Reduction|nmod|START_ENTITY Reduction|appos|END_ENTITY	Reduction of cytosolic p27 -LRB- Kip1 -RRB- inhibits cancer cell motility , survival , and tumorigenicity .
16528608	0	p27	12,15	Kip1	16,20	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of p27 -LRB- Kip1 -RRB- expression in insulinomas developed in pancreatic beta-cell specific Men1 mutant mice .
16972266	0	p27	102,105	Kip1	106,110	p27	Kip1	10671	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Extracellular adenosine_triphosphate protects oxidative stress-induced increase of p21 -LRB- WAF1/Cip1 -RRB- and p27 -LRB- Kip1 -RRB- expression in primary cultured renal proximal tubule cells : role of PI3K and Akt signaling .
17216128	0	p27	90,93	Kip1	94,98	p27	Kip1	10671	1027	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27 -LRB- Kip1 -RRB- induction .
17310312	0	p27	8,11	Kip1	12,16	p27	Kip1	10534	1027	Gene	Gene	CDKI|compound|START_ENTITY CDKI|appos|END_ENTITY	Loss of p27 -LRB- Kip1 -RRB- CDKI is a predictor of poor recurrence-free and cancer-specific survival in patients with renal_cancer .
17356514	0	p27	100,103	Kip1	104,108	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Defects in retinal_pigment_epithelium cell proliferation and retinal attachment in mutant mice with p27 -LRB- Kip1 -RRB- gene ablation .
17577273	0	p27	4,7	Kip1	8,12	p27	Kip1	3429	1027	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Low p27 -LRB- Kip1 -RRB- expression is associated with poor prognostic factors in breast_carcinomas .
17627278	0	p27	18,21	Kip1	22,26	p27	Kip1	10534	1027	Gene	Gene	suppressor|amod|START_ENTITY suppressor|appos|END_ENTITY	Regulation of the p27 -LRB- Kip1 -RRB- tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation .
18075313	0	p27	24,27	Kip1	28,32	p27	Kip1	3429	1027	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Multiple mechanisms for p27 -LRB- Kip1 -RRB- translocation and degradation .
18311148	0	p27	83,86	Kip1	87,91	p27	Kip1	3429	1027	Gene	Gene	stability|amod|START_ENTITY stability|appos|END_ENTITY	Protein kinase CK2 links extracellular growth factor signaling with the control of p27 -LRB- Kip1 -RRB- stability in the heart .
18566599	0	p27	50,53	Kip1	54,58	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The death domain-containing kinase RIP1 regulates p27 -LRB- Kip1 -RRB- levels through the PI3K-Akt-forkhead pathway .
19066472	0	p27	45,48	Kip1	49,53	p27	Kip1	10671	1027	Gene	Gene	tyrosine|amod|START_ENTITY tyrosine|appos|END_ENTITY	Tyrosine phosphatase SHP-2 is a regulator of p27 -LRB- Kip1 -RRB- tyrosine phosphorylation .
19077036	0	p27	21,24	Kip1	25,29	p27	Kip1	10671	1027	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	E2F-like elements in p27 -LRB- Kip1 -RRB- promoter specifically sense deregulated E2F activity .
19079342	0	p27	46,49	Kip1	50,54	p27	Kip1	3429	1027	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Id-1 activates Akt-mediated Wnt signaling and p27 -LRB- Kip1 -RRB- phosphorylation through PTEN inhibition .
19451650	4	p27	851,854	Kip1	855,859	p27	Kip1	10671	1027	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	Experiments with BGLF4 knockdown by small interfering RNA and BGLF4 knock-out viruses clarified that EBV PK is involved in p27 -LRB- Kip1 -RRB- degradation upon lytic replication .
19513905	0	p27	132,135	Kip1	136,140	p27	Kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mitochondrial reactive oxygen species originating from Romo1 exert an important role in normal cell cycle progression by regulating p27 -LRB- Kip1 -RRB- expression .
19672859	0	p27	49,52	Kip1	53,57	p27	Kip1	3429	1027	Gene	Gene	reduction|nmod|START_ENTITY reduction|appos|END_ENTITY	The reduction of cell death and proliferation by p27 -LRB- Kip1 -RRB- minimizes DNA damage in an experimental model of genotoxicity .
19866239	0	p27	166,169	Kip1	171,175	p27	Kip1	3429	1027	Gene	Gene	prognosticator|nmod|START_ENTITY turnover|dep|prognosticator turnover|appos|END_ENTITY	CKS1B overexpression implicates clinical aggressiveness_of_hepatocellular_carcinomas but not p27 -LRB- Kip1 -RRB- protein turnover : an independent prognosticator with potential p27 -LRB- Kip1 -RRB- - independent oncogenic attributes ?
19959471	0	p27	24,27	Kip1	28,32	p27	Kip1	10671	1027	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mitogenic regulation of p27 -LRB- Kip1 -RRB- gene is mediated by AP-1 transcription factors .
20170512	0	p27	41,44	Kip1	45,49	p27	Kip1	10671	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upstream molecular signaling pathways of p27 -LRB- Kip1 -RRB- expression : effects of 4-hydroxytamoxifen , dexamethasone , and retinoic_acids .
20356461	0	p27	76,79	Kip1	80,84	p27	Kip1	3429	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Novel p104 protein regulates cell proliferation through PI3K inhibition and p27 -LRB- Kip1 -RRB- expression .
20837141	0	p27	20,23	Kip1	24,28	p27	Kip1	10671	1027	Gene	Gene	stability|amod|START_ENTITY stability|appos|END_ENTITY	Cyclin_D1 regulates p27 -LRB- Kip1 -RRB- stability in B cells .
20837141	4	p27	530,533	Kip1	534,538	p27	Kip1	10671	1027	Gene	Gene	phosphorylated|amod|START_ENTITY phosphorylated|appos|END_ENTITY	But , only the p27 -LRB- Kip1 -RRB- form phosphorylated on serine 10 -LRB- pSer10-p27 -LRB- Kip1 -RRB- -RRB- accumulates in BD1-9 cells .
20935455	0	p27	74,77	Kip1	78,82	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Oct1 is required for mTOR-induced G1 cell cycle arrest via the control of p27 -LRB- Kip1 -RRB- expression .
21067268	0	p27	12,15	Kip1	16,20	p27	Kip1	10534	1027	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of p27 -LRB- Kip1 -RRB- phosphorylation at serine 10 in the migration of malignant_glioma cells in vitro .
21216562	0	p27	47,50	Kip1	52,56	p27	Kip1	10534	1027	Gene	Gene	Ser|amod|START_ENTITY Ser|appos|END_ENTITY	Variation of gene expression profile linked to p27 -LRB- Kip1 -RRB- Ser -LRB- 10 -RRB- phosphorylation status in MCF-7 cell line .
21236467	0	p27	23,26	Kip1	101,105	p27	Kip1	3429	1027	Gene	Gene	ligase|amod|START_ENTITY Expression|appos|ligase Expression|dep|correlation correlation|nmod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	p27	23,26	Kip1	27,31	p27	Kip1	3429	1027	Gene	Gene	ligase|amod|START_ENTITY ligase|appos|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	p27	97,100	Kip1	27,31	p27	Kip1	3429	1027	Gene	Gene	Kip1|amod|START_ENTITY correlation|nmod|Kip1 Expression|dep|correlation Expression|appos|ligase ligase|appos|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21299246	0	p27	129,132	Kip1	95,99	p27	Kip1	10671	1027	Gene	Gene	disruption|nmod|START_ENTITY attributed|nmod|disruption END_ENTITY|acl|attributed	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21299246	0	p27	91,94	Kip1	133,137	p27	Kip1	10671	1027	Gene	Gene	Kip1|amod|START_ENTITY Kip1|acl|attributed attributed|nmod|disruption disruption|nmod|p27 p27|appos|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21593789	5	p27	793,796	Kip1	797,801	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	We show that in 3D cocultured PKC - null keratinocytes , p27 -LRB- Kip1 -RRB- mRNA was downregulated , whereas JNK/c-Jun signaling was enhanced .
21795702	0	p27	98,101	Kip1	102,106	p27	Kip1	10671	1027	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	WW_domain-containing_E3_ubiquitin_protein_ligase_1 -LRB- WWP1 -RRB- delays cellular senescence by promoting p27 -LRB- Kip1 -RRB- degradation in human diploid fibroblasts .
21813412	0	p27	12,15	Kip1	16,20	p27	Kip1	10671	1027	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of p27 -LRB- Kip1 -RRB- in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian_cancer cells .
21906315	0	p27	41,44	Kip1	45,49	p27	Kip1	3429	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upstream molecular signaling pathways of p27 -LRB- Kip1 -RRB- expression in human breast_cancer cells in vitro : differential effects of 4-hydroxytamoxifen and deficiency of either D - -LRB- + -RRB- - glucose or L-leucine .
22014979	0	p27	73,76	Kip1	77,81	p27	Kip1	3429	1027	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27 -LRB- Kip1 -RRB- phosphorylation .
22580455	0	p27	14,17	Kip1	19,23	p27	Kip1	10671	1027	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of p27 -LRB- Kip1 -RRB- by mitogen-induced tyrosine phosphorylation .
23312942	0	p27	40,43	Kip1	44,48	p27	Kip1	3429	1027	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A single nucleotide polymorphism in the p27 -LRB- Kip1 -RRB- gene is associated with primary patency of lower extremity vein bypass grafts .
23354589	0	p27	46,49	Kip1	50,54	p27	Kip1	10671	1027	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	A novel cyclinE/cyclinA-CDK inhibitor targets p27 -LRB- Kip1 -RRB- degradation , cell cycle progression and cell survival : implications in cancer therapy .
23910095	0	p27	47,50	Kip1	51,55	p27	Kip1	10671	1027	Gene	Gene	inhibitors|nmod|START_ENTITY Identification|nmod|inhibitors Identification|appos|END_ENTITY	Identification of small molecule inhibitors of p27 -LRB- Kip1 -RRB- ubiquitination by high-throughput screening .
24170542	0	p27	32,35	Kip1	36,40	p27	Kip1	10534	1027	Gene	Gene	accumulation|amod|START_ENTITY accumulation|compound|END_ENTITY	Adhesion to fibronectin induces p27 -LRB- Kip1 -RRB- nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance -LRB- CAM-DR -RRB- in RPMI 8,226 cells .
24751519	0	p27	25,28	Kip1	29,33	p27	Kip1	10671	1027	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	IKK-b/NF-kB p65 mediates p27 -LRB- Kip1 -RRB- protein degradation in arsenite response .
25430995	0	p27	104,107	Kip1	108,112	p27	Kip1	10671	1027	Gene	Gene	arrest|amod|START_ENTITY arrest|appos|END_ENTITY	Nardostachys chinensis induces granulocytic differentiation with the suppression of cell growth through p27 -LRB- Kip1 -RRB- protein-related G0/G1 phase arrest in human promyelocytic leukemic cells .
25960164	0	p27	162,165	Kip1	166,170	p27	Kip1	3429	1027	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The activation of type 1 corticotropin_releasing_factor receptor -LRB- CRF-R1 -RRB- inhibits proliferation and promotes differentiation of neuroblastoma cells in vitro via p27 -LRB- Kip1 -RRB- protein up-regulation and c-Myc mRNA down-regulation .
26507530	0	p27	66,69	Kip1	70,74	p27	Kip1	3429	1027	Gene	Gene	Protein|appos|START_ENTITY Protein|appos|END_ENTITY	Discovery of Small Molecules that Inhibit the Disordered Protein , p27 -LRB- Kip1 -RRB- .
26902224	0	p27	134,137	Kip1	138,142	p27	Kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	Fad24 , a Positive Regulator of Adipogenesis , Is Required for S Phase Re-entry of C2C12 Myoblasts Arrested in G0 Phase and Involved in p27 -LRB- Kip1 -RRB- Expression at the Protein Level .
27082696	0	p27	31,34	Kip1	35,39	p27	Kip1	10534	1027	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	The non-canonical functions of p27 -LRB- Kip1 -RRB- in normal and tumor biology .
8630967	0	p27	106,109	Kip1	110,114	p27	Kip1	3429	1027	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Molecular analysis of the cyclin-dependent kinase inhibitor family : p16 -LRB- CDKN2/MTS1/INK4A -RRB- , p18 -LRB- INK4C -RRB- and p27 -LRB- Kip1 -RRB- genes in neuroblastomas .
9054402	0	p27	34,37	Kip1	38,42	p27	Kip1	3429	1027	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Enhanced ribosomal association of p27 -LRB- Kip1 -RRB- mRNA is a mechanism contributing to accumulation during growth_arrest .
9815577	0	p27	26,29	Kip1	30,34	p27	Kip1	3429	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Deregulated expression of p27 -LRB- Kip1 -RRB- in human breast_cancers .
9815624	0	p27	46,49	Kip1	50,54	p27	Kip1	10534	1027	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Loss of the cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- protein in human prostate_cancer correlates with tumor grade .
9927425	0	p27	14,17	Kip1	18,22	p27	Kip1	3429	1027	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Modulation of p27 -LRB- Kip1 -RRB- levels by the cyclin encoded by Kaposi 's _ sarcoma-associated_herpesvirus .
17404431	0	p27	27,30	Kip_1	31,36	p27	Kip 1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of p27 -LRB- Kip_1 -RRB- expression in renal_cell_carcinoma .
17404436	0	p27	19,22	Kip_1	23,28	p27	Kip 1	3429	1027	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Down-regulation of p27 -LRB- Kip_1 -RRB- cyclin-dependent kinase inhibitor in prostate_cancer : distinct expression in various prostate cells associating with tumor stage and grades .
10329038	0	p27	75,78	MDM2	64,68	p27	MDM2	3429	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
25851349	0	p27	78,81	Mdig	0,4	p27	Mdig	10671	84864	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Mdig , a lung_cancer-associated gene , regulates cell cycle progression through p27 -LRB- KIP1 -RRB- .
16491347	0	p27	97,100	PCNA	55,59	p27	PCNA	3429	5111	Gene	Gene	p21|nummod|START_ENTITY inhibitors|dep|p21 Ki67|amod|inhibitors Ki67|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
25205104	0	p27	24,27	PCTAIRE1	0,8	p27	PCTAIRE1	10534	5127	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	PCTAIRE1 phosphorylates p27 and regulates mitosis in cancer cells .
25593992	0	p27	19,22	PCTAIRE1	0,8	p27	PCTAIRE1	10534	5127	Gene	Gene	apoptosis|amod|START_ENTITY regulates|dobj|apoptosis regulates|nsubj|END_ENTITY	PCTAIRE1 regulates p27 stability , apoptosis and tumor growth in malignant_melanoma .
23336417	0	p27	38,41	PTEN	43,47	p27	PTEN	10671	5728	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	-LSB- The expression and meanning of Skp2 , p27 , PTEN proteins in non-Hodgkin B-cell lymphoma_of_ocular_adnexa -RSB- .
21236467	0	p27	23,26	Pirh2	14,19	p27	Pirh2	3429	25898	Gene	Gene	ligase|amod|START_ENTITY Expression|appos|ligase Expression|nmod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
21236467	0	p27	97,100	Pirh2	14,19	p27	Pirh2	3429	25898	Gene	Gene	Kip1|amod|START_ENTITY correlation|nmod|Kip1 Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of Pirh2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in hepatocellular_carcinoma : correlation with p27 -LRB- Kip1 -RRB- and cell proliferation .
18566599	0	p27	50,53	RIP1	35,39	p27	RIP1	12576(Tax:10090)	19766(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	The death domain-containing kinase RIP1 regulates p27 -LRB- Kip1 -RRB- levels through the PI3K-Akt-forkhead pathway .
18289677	0	p27	103,106	Rv2108	108,114	p27	Rv2108	12576(Tax:10090)	887814(Tax:83332)	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Flagellin as a good carrier and potent adjuvant for Th1 response : study of mice immune response to the p27 -LRB- Rv2108 -RRB- Mycobacterium_tuberculosis antigen .
11943729	0	p27	99,102	S-phase_kinase-associated_protein_2	0,35	p27	S-phase kinase-associated protein 2	3429	6502	Gene	Gene	expression|amod|START_ENTITY correlates|nmod|expression correlates|nsubj|expression expression|amod|END_ENTITY	S-phase_kinase-associated_protein_2 expression in non-Hodgkin 's _ lymphoma inversely correlates with p27 expression and defines cells in S phase .
24560885	0	p27	29,32	SCCA1	51,56	p27	SCCA1	10671	6317	Gene	Gene	generated|nsubjpass|START_ENTITY generated|nmod|END_ENTITY	Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase .
10559916	0	p27	73,76	SKP2	0,4	p27	SKP2	10671	6502	Gene	Gene	degradation|nmod|START_ENTITY required|nmod|degradation required|nsubjpass|END_ENTITY	SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 .
11250155	0	p27	72,75	SKP2	118,122	p27	SKP2	10671	6502	Gene	Gene	degradation|nmod|START_ENTITY regulates|dobj|degradation regulates|nmod|SCF SCF|appos|END_ENTITY	PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27 -LRB- KIP1 -RRB- through the ubiquitin E3 ligase SCF -LRB- SKP2 -RRB- .
12188931	0	p27	52,55	SKP2	18,22	p27	SKP2	10671	6502	Gene	Gene	stability|amod|START_ENTITY control|nmod|stability mediates|dobj|control mediates|nsubj|END_ENTITY	The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate_cancer cells .
16988944	0	p27	41,44	SKP2	68,72	p27	SKP2	10671	6502	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of the KIP family members p27 -LRB- KIP1 -RRB- and p57 -LRB- KIP2 -RRB- by SKP2 and the role of methylation in p57 -LRB- KIP2 -RRB- inactivation in nonsmall_cell_lung_cancer .
21245140	0	p27	65,68	SKP2	83,87	p27	SKP2	10671	6502	Gene	Gene	MYC|dobj|START_ENTITY MYC|nmod|END_ENTITY	SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27 -LRB- KIP1 -RRB- through SKP2 in human leukemia cells .
21503567	0	p27	28,31	SKP2	68,72	p27	SKP2	10534	6502	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|direct direct|nmod|END_ENTITY	Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian_and_breast_cancer .
22372491	0	p27	42,45	SKP2	27,31	p27	SKP2	10671	6502	Gene	Gene	stabilization|amod|START_ENTITY induce|dobj|stabilization END_ENTITY|xcomp|induce	Prodigiosin down-regulates SKP2 to induce p27 -LRB- KIP1 -RRB- stabilization and antiproliferation in human lung_adenocarcinoma cells .
24443386	0	p27	78,81	SKP2	0,4	p27	SKP2	3429	6502	Gene	Gene	pSer10p27|amod|START_ENTITY phosphorylation|nmod|pSer10p27 associated|nmod|phosphorylation associated|nsubjpass|overexpression overexpression|compound|END_ENTITY	SKP2 overexpression is associated with increased serine 10 phosphorylation of p27 -LRB- pSer10p27 -RRB- in triple-negative breast_cancer .
25070589	0	p27	46,49	SKP2	28,32	p27	SKP2	10671	6502	Gene	Gene	stabilize|dobj|START_ENTITY END_ENTITY|xcomp|stabilize	Sulforaphane down-regulates SKP2 to stabilize p27 -LRB- KIP1 -RRB- for inducing antiproliferation in human colon_adenocarcinoma cells .
21785466	0	p27	97,100	SRC	30,33	p27	SRC	12576(Tax:10090)	20779(Tax:10090)	Gene	Gene	stabilization|amod|START_ENTITY induce|nmod|stabilization inhibitors|xcomp|induce inhibitors|nsubj|END_ENTITY	New pyrazolo -LSB- 3,4-d -RSB- pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization .
16425372	0	p27	93,96	S_phase_kinase-associated_protein_2	30,65	p27	S phase kinase-associated protein 2	10671	6502	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Relation of overexpression of S_phase_kinase-associated_protein_2 with reduced expression of p27 and PTEN in human gastric_carcinoma .
11726503	0	p27	0,3	Ser10	64,69	p27	Ser10	10671	3190220(Tax:176280)	Gene	Gene	localization|amod|START_ENTITY regulated|nsubjpass|localization regulated|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis .
20811053	0	p27	98,101	Ser10	105,110	p27	Ser10	10671	3190220(Tax:176280)	Gene	Gene	phosphorylation|nmod|START_ENTITY FGF-2-mediated|nmod|phosphorylation FGF-2-mediated|nmod|END_ENTITY	PI_3-kinase / Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2 .
21948550	0	p27	58,61	Ser10	76,81	p27	Ser10	10671	3190220(Tax:176280)	Gene	Gene	Kip1|amod|START_ENTITY Kip1|nmod|END_ENTITY	Human corneal endothelial cells employ phosphorylation of p27 -LRB- Kip1 -RRB- at both Ser10 and Thr187 sites for FGF-2-mediated cell proliferation via PI 3-kinase .
25908026	0	p27	8,11	Ser10	31,36	p27	Ser10	12576(Tax:10090)	3190220(Tax:176280)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK .
25908026	0	p27	8,11	Ser10	31,36	p27	Ser10	12576(Tax:10090)	3190220(Tax:176280)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Loss of p27 phosphorylation at Ser10 accelerates early atherogenesis by promoting leukocyte recruitment via RhoA/ROCK .
10375532	0	p27	0,3	Skp2	65,69	p27	Skp2	10671	6502	Gene	Gene	ubiquitination|amod|START_ENTITY regulated|nsubjpass|ubiquitination regulated|nmod|complex complex|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
10375532	0	p27	112,115	Skp2	65,69	p27	Skp2	10671	6502	Gene	Gene	Thr187|nmod|START_ENTITY complex|nmod|Thr187 complex|appos|END_ENTITY	p27 -LRB- Kip1 -RRB- ubiquitination and degradation is regulated by the SCF -LRB- Skp2 -RRB- complex through phosphorylated Thr187 in p27 .
11231585	0	p27	94,97	Skp2	59,63	p27	Skp2	10671	6502	Gene	Gene	ubiquitinylation|nmod|START_ENTITY SCF|dep|ubiquitinylation SCF|appos|END_ENTITY	The cell-cycle regulatory protein Cks1 is required for SCF -LRB- Skp2 -RRB- - mediated ubiquitinylation of p27 .
11335900	0	p27	35,38	Skp2	81,85	p27	Skp2	10671	6502	Gene	Gene	levels|nmod|START_ENTITY relation|nmod|levels ligase|nsubj|relation ligase|dobj|END_ENTITY	Inverse relation between levels of p27 -LRB- Kip1 -RRB- and of its ubiquitin ligase subunit Skp2 in colorectal_carcinomas .
11738146	0	p27	27,30	Skp2	112,116	p27	Skp2	10671	6502	Gene	Gene	stabilization|nmod|START_ENTITY correlates|nsubj|stabilization correlates|nmod|expression expression|nmod|END_ENTITY	Metabolic stabilization of p27 in senescent fibroblasts correlates with reduced expression of the F-box protein Skp2 .
11818378	0	p27	15,18	Skp2	40,44	p27	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY degradation|nsubj|Involvement degradation|nmod|END_ENTITY	Involvement of p27 -LRB- KIP1 -RRB- degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium .
12097295	0	p27	192,195	Skp2	158,162	p27	Skp2	10534	6502	Gene	Gene	proteolysis|amod|START_ENTITY significance|nmod|proteolysis significance|dep|modulation modulation|nmod|phenotype phenotype|nmod|overexpression overexpression|amod|END_ENTITY	Clinical and biological significance of S-phase_kinase-associated_protein_2 -LRB- Skp2 -RRB- gene expression in gastric_carcinoma : modulation of malignant phenotype by Skp2 overexpression , possibly via p27 proteolysis .
12097295	0	p27	192,195	Skp2	77,81	p27	Skp2	10534	6502	Gene	Gene	proteolysis|amod|START_ENTITY significance|nmod|proteolysis significance|nmod|expression expression|amod|S-phase_kinase-associated_protein_2 S-phase_kinase-associated_protein_2|dep|END_ENTITY	Clinical and biological significance of S-phase_kinase-associated_protein_2 -LRB- Skp2 -RRB- gene expression in gastric_carcinoma : modulation of malignant phenotype by Skp2 overexpression , possibly via p27 proteolysis .
12351407	0	p27	22,25	Skp2	14,18	p27	Skp2	10671	6502	Gene	Gene	ligase|amod|START_ENTITY Expression|appos|ligase Expression|nmod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12351407	0	p27	90,93	Skp2	14,18	p27	Skp2	10671	6502	Gene	Gene	Kip1|amod|START_ENTITY correlation|nmod|Kip1 Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of Skp2 , a p27 -LRB- Kip1 -RRB- ubiquitin ligase , in malignant_lymphoma : correlation with p27 -LRB- Kip1 -RRB- and proliferation index .
12408227	0	p27	84,87	Skp2	93,97	p27	Skp2	10534	6502	Gene	Gene	association|nmod|START_ENTITY diminish|dobj|association diminish|nmod|independent independent|amod|END_ENTITY	Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells .
12429629	0	p27	122,125	Skp2	9,13	p27	Skp2	10671	6502	Gene	Gene	loss|nmod|START_ENTITY association|nmod|loss expression|dep|association expression|amod|END_ENTITY	Elevated Skp2 protein expression in human prostate_cancer : association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival .
12704665	0	p27	84,87	Skp2	18,22	p27	Skp2	10671	6502	Gene	Gene	expression|amod|START_ENTITY correlate|nmod|expression correlate|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of Skp2 in carcinoma_of_the_cervix does not correlate inversely with p27 expression .
14558671	0	p27	71,74	Skp2	36,40	p27	Skp2	10671	6502	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|nmod|END_ENTITY	The expression of the F-box protein Skp2 is negatively associated with p27 expression in human pituitary_tumors .
14707456	0	p27	67,70	Skp2	0,4	p27	Skp2	10534	6502	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	Skp2 and Jab1 expression are associated with inverse expression of p27 -LRB- KIP1 -RRB- and poor prognosis in oral_squamous_cell_carcinomas .
14734747	0	p27	54,57	Skp2	113,117	p27	Skp2	10671	6502	Gene	Gene	regulation|dep|START_ENTITY regulation|dep|arrest arrest|acl|mediated mediated|nmod|inhibition inhibition|nmod|transcription transcription|amod|END_ENTITY	Nuclear pro-IL-16 regulation of T cell proliferation : p27 -LRB- KIP1 -RRB- - dependent G0/G1 arrest mediated by inhibition of Skp2 transcription .
15161026	0	p27	49,52	Skp2	86,90	p27	Skp2	10671	6502	Gene	Gene	levels|nmod|START_ENTITY correlation|nmod|levels ligase|nsubj|correlation ligase|dobj|END_ENTITY	Inverse correlation between expression levels of p27 and the ubiquitin ligase subunit Skp2 in early esophageal_squamous_cell_carcinoma .
15351619	0	p27	14,17	Skp2	51,55	p27	Skp2	10671	6502	Gene	Gene	Expression|nmod|START_ENTITY ligase|nsubj|Expression ligase|dobj|END_ENTITY	Expression of p27 and its ubiquitin ligase subunit Skp2 in upper urinary_tract_transitional_cell_carcinoma .
15579456	0	p27	97,100	Skp2	79,83	p27	Skp2	10671	6502	Gene	Gene	degradation|amod|START_ENTITY promoting|dobj|degradation END_ENTITY|acl|promoting	Role of Cks1 overexpression in oral_squamous_cell_carcinomas : cooperation with Skp2 in promoting p27 degradation .
16209941	0	p27	54,57	Skp2	75,79	p27	Skp2	10671	6502	Gene	Gene	Kip1|amod|START_ENTITY Kip1|nmod|ubiquitin ubiquitin|appos|END_ENTITY	Structural basis of the Cks1-dependent recognition of p27 -LRB- Kip1 -RRB- by the SCF -LRB- Skp2 -RRB- ubiquitin ligase .
16425184	0	p27	29,32	Skp2	54,58	p27	Skp2	10671	6502	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
17384652	0	p27	69,72	Skp2	0,4	p27	Skp2	10671	6502	Gene	Gene	gallbladder_carcinoma|nmod|START_ENTITY prognosticator|nmod|gallbladder_carcinoma prognosticator|nsubj|END_ENTITY	Skp2 is an independent prognosticator of gallbladder_carcinoma among p27 -LRB- Kip1 -RRB- - interacting cell cycle regulators : an immunohistochemical study of 62 cases by tissue microarray .
17431674	0	p27	54,57	Skp2	0,4	p27	Skp2	10671	6502	Gene	Gene	protein|amod|START_ENTITY down-regulation|nmod|protein associated|nmod|down-regulation associated|nsubjpass|expression expression|amod|END_ENTITY	Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid_cystic_carcinoma .
17475922	0	p27	39,42	Skp2	68,72	p27	Skp2	10671	6502	Gene	Gene	Regulation|nmod|START_ENTITY ligase|nsubj|Regulation ligase|dobj|END_ENTITY	Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells .
18305219	0	p27	14,17	Skp2	32,36	p27	Skp2	10671	6502	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Targeting the p27 E3 ligase SCF -LRB- Skp2 -RRB- results in p27 - and Skp2-mediated cell-cycle arrest and activation of autophagy .
18305219	0	p27	49,52	Skp2	32,36	p27	Skp2	10671	6502	Gene	Gene	arrest|amod|START_ENTITY results|nmod|arrest results|appos|END_ENTITY	Targeting the p27 E3 ligase SCF -LRB- Skp2 -RRB- results in p27 - and Skp2-mediated cell-cycle arrest and activation of autophagy .
18604603	0	p27	31,34	Skp2	0,4	p27	Skp2	10671	6502	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Skp2 inversely correlates with p27 and tuberin in transformed cells .
19364496	0	p27	0,3	Skp2	20,24	p27	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	deregulation|amod|START_ENTITY deregulation|nmod|overexpression overexpression|amod|END_ENTITY	p27 deregulation by Skp2 overexpression induced by the JAK2V617 mutation .
21299246	0	p27	129,132	Skp2	139,143	p27	Skp2	10671	6502	Gene	Gene	START_ENTITY|dep|complex complex|dep|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
21299246	0	p27	91,94	Skp2	139,143	p27	Skp2	10671	6502	Gene	Gene	Kip1|amod|START_ENTITY Kip1|acl|attributed attributed|nmod|disruption disruption|nmod|p27 p27|dep|complex complex|dep|END_ENTITY	Gallic_acid induces G2/M phase arrest of breast_cancer cell MCF-7 through stabilization of p27 -LRB- Kip1 -RRB- attributed to disruption of p27 -LRB- Kip1 -RRB- / Skp2 complex .
22484732	0	p27	41,44	Skp2	84,88	p27	Skp2	10671	6502	Gene	Gene	stability|nmod|START_ENTITY enhances|dobj|stability enhances|nmod|regulation regulation|nmod|END_ENTITY	Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast_cancer cells .
22558406	0	p27	99,102	Skp2	91,95	p27	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The amelioration of renal_damage in Skp2-deficient mice canceled by p27_Kip1 deficiency in Skp2 - / - p27 - / - mice .
23474082	0	p27	68,71	Skp2	0,4	p27	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	accumulation|compound|START_ENTITY independent|nmod|accumulation inhibits|xcomp|independent inhibits|nsubj|deficiency deficiency|amod|END_ENTITY	Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27 -LRB- Kip1 -RRB- accumulation .
24229711	0	p27	24,27	Skp2	0,4	p27	Skp2	3429	6502	Gene	Gene	safeguard|nsubj|START_ENTITY unmasks|ccomp|safeguard unmasks|nsubj|deletion deletion|compound|END_ENTITY	Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors .
24269842	0	p27	0,3	Skp2	34,38	p27	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	p27 is regulated independently of Skp2 in the absence of Cdk2 .
25132260	0	p27	114,117	Skp2	128,132	p27	Skp2	3429	6502	Gene	Gene	Kip1|amod|START_ENTITY Kip1|nmod|END_ENTITY	CCN5/WISP -2 promotes growth arrest of triple-negative_breast_cancer cells through accumulation and trafficking of p27 -LRB- Kip1 -RRB- via Skp2 and FOXO3a regulation .
26114183	0	p27	43,46	Skp2	12,16	p27	Skp2	10671	6502	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of Skp2 and its substrate CDKN1B -LRB- p27 -RRB- in colorectal_cancer .
26682002	0	p27	40,43	Skp2	107,111	p27	Skp2	10671	6502	Gene	Gene	Increase|dobj|START_ENTITY Increase|advcl|Affecting Affecting|nmod|Downregulation Downregulation|compound|END_ENTITY	Histone Deacetylase Inhibitors Increase p27 -LRB- Kip1 -RRB- by Affecting Its Ubiquitin-Dependent Degradation through Skp2 Downregulation .
26795496	0	p27	0,3	Skp2	29,33	p27	Skp2	10671	6502	Gene	Gene	ligase|nsubj|START_ENTITY ligase|dobj|expression expression|amod|END_ENTITY	p27 and its ubiquitin ligase Skp2 expression in endometrium of IVF patients with repeated hormonal stimulation .
23217425	0	p27	0,3	Sox2	29,33	p27	Sox2	12576(Tax:10090)	20674(Tax:10090)	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	p27 -LRB- Kip1 -RRB- directly represses Sox2 during embryonic stem cell differentiation .
11231912	0	p27	32,35	Sp1	8,11	p27	Sp1	83571(Tax:10116)	24790(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	Role of Sp1 in the induction of p27 gene expression in vascular smooth muscle cells in vitro and after balloon angioplasty .
17254967	0	p27	0,3	Src	23,26	p27	Src	10671	6714	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2 .
8816905	0	p27	27,30	TGF-beta	48,56	p27	TGF-beta	12576(Tax:10090)	21803(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Differential regulation of p27 and cyclin_D1 by TGF-beta and EGF in C3H 10T1/2 mouse fibroblasts .
25536447	0	p27	69,72	TIPE2	50,55	p27	TIPE2	3429	79626	Gene	Gene	upregulates|xcomp|START_ENTITY upregulates|nsubj|Tumor_necrosis_factor-a-induced_protein-8_like-2 Tumor_necrosis_factor-a-induced_protein-8_like-2|appos|END_ENTITY	Tumor_necrosis_factor-a-induced_protein-8_like-2 -LRB- TIPE2 -RRB- upregulates p27 to decrease gastic_cancer cell proliferation .
26781452	0	p27	56,59	TIPE2	0,5	p27	TIPE2	22428(Tax:10090)	69769(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TIPE2 , a negative regulator of TLR signaling , regulates p27 through IRF4-induced signaling .
10329038	0	p27	75,78	TP53	58,62	p27	TP53	3429	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
21075101	0	p27	34,37	Tumor_necrosis_factor-a	0,23	p27	Tumor necrosis factor-a	3429	7124	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-a regulates p27 kip expression and apoptosis in smooth muscle cells of human carotid plaques via forkhead transcription factor O1 .
24457952	0	p27	72,75	UCA1	20,24	p27	UCA1	3429	652995	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	Long non-coding RNA UCA1 promotes breast_tumor growth by suppression of p27 -LRB- Kip1 -RRB- .
16998811	0	p27	72,75	VEGF	43,47	p27	VEGF	3429	7422	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
27033900	0	p27	123,126	bcl-2	133,138	p27	bcl-2	10671	596	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27 , p53 , bcl-2 in canine breast_cancer cells .
10329038	0	p27	75,78	cdk4	80,84	p27	cdk4	3429	1019	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
24560885	0	p27	29,32	chymase	62,69	p27	chymase	10671	1215	Gene	Gene	generated|nsubjpass|START_ENTITY generated|nmod|END_ENTITY	Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase .
9927425	0	p27	14,17	cyclin	38,44	p27	cyclin	3429	5111	Gene	Gene	levels|amod|START_ENTITY Modulation|nmod|levels Modulation|nmod|END_ENTITY	Modulation of p27 -LRB- Kip1 -RRB- levels by the cyclin encoded by Kaposi 's _ sarcoma-associated_herpesvirus .
15731113	0	p27	115,118	cyclin-dependent_kinase_2	77,102	p27	cyclin-dependent kinase 2	10671	1017	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Regulation of vascular smooth muscle proliferation by heparin : inhibition of cyclin-dependent_kinase_2 activity by p27 -LRB- kip1 -RRB- .
11706071	0	p27	18,21	cyclin_A	128,136	p27	cyclin A	3429	890	Gene	Gene	protein|amod|START_ENTITY expression|nmod|protein associated|nsubjpass|expression associated|nmod|expression expression|nmod|END_ENTITY	Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin_A and cyclin_B1 in diffuse_large_B-cell_lymphomas .
14747563	0	p27	57,60	cyclin_A	48,56	p27	cyclin A	10671	890	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Epstein-Barr_virus nuclear antigen 3C regulates cyclin_A / p27 complexes and enhances cyclin_A-dependent kinase activity .
16491347	0	p27	97,100	cyclin_A	45,53	p27	cyclin A	3429	890	Gene	Gene	p21|nummod|START_ENTITY inhibitors|dep|p21 Ki67|amod|inhibitors Ki67|dep|END_ENTITY	Location of cell cycle regulators cyclin_B1 , cyclin_A , PCNA , Ki67 and cell cycle inhibitors p21 , p27 and p57 in human first trimester placenta and deciduas .
19624419	0	p27	62,65	cyclin_A	52,60	p27	cyclin A	3429	890	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
9860976	0	p27	38,41	cyclin_A	91,99	p27	cyclin A	3429	890	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|cleavage cleavage|nmod|END_ENTITY	The cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- induces N-terminal proteolytic cleavage of cyclin_A .
10329038	0	p27	75,78	cyclin_D1	86,95	p27	cyclin D1	3429	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
11115553	0	p27	23,26	cyclin_D1	44,53	p27	cyclin D1	10671	595	Gene	Gene	START_ENTITY|acl|inhibit inhibit|dobj|END_ENTITY	Insufficient effect of p27 -LRB- KIP1 -RRB- to inhibit cyclin_D1 in human esophageal_cancer in vitro .
11123420	0	p27	98,101	cyclin_D1	24,33	p27	cyclin D1	83571(Tax:10116)	58919(Tax:10116)	Gene	Gene	Kip1|amod|START_ENTITY expression|nmod|Kip1 associated|nmod|expression associated|nsubj|expression expression|nmod|END_ENTITY	Increased expression of cyclin_D1 , cyclin_E and p21 -LRB- Cip1 -RRB- associated with decreased expression of p27 -LRB- Kip1 -RRB- in chemically induced rat mammary carcinogenesis .
19242098	0	p27	101,104	cyclin_D1	106,115	p27	cyclin D1	3429	595	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric_cancer cells by regulating p27 , cyclin_D1 expression and cytochrome_C release .
19624419	0	p27	62,65	cyclin_D1	41,50	p27	cyclin D1	3429	595	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
20843055	0	p27	56,59	cyclin_D1	38,47	p27	cyclin D1	3429	595	Gene	Gene	reveals|dobj|START_ENTITY reveals|nsubj|analysis analysis|nmod|END_ENTITY	Structural and functional analysis of cyclin_D1 reveals p27 and substrate inhibitor binding requirements .
21693435	0	p27	44,47	cyclin_D1	53,62	p27	cyclin D1	83571(Tax:10116)	58919(Tax:10116)	Gene	Gene	mislocalization|nmod|START_ENTITY mislocalization|dep|END_ENTITY	cAMP-dependent cytosolic mislocalization of p27 -LRB- kip -RRB- - cyclin_D1 during quinol-thioether-induced tuberous_sclerosis renal cell carcinoma .
23639288	0	p27	0,3	cyclooxygenase-2	15,31	p27	cyclooxygenase-2	10671	5743	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|amod|END_ENTITY	p27 suppresses cyclooxygenase-2 expression by inhibiting p38b and p38 - mediated CREB phosphorylation upon arsenite exposure .
10644940	0	p27	27,30	kip1	31,35	p27	kip1	3429	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of p27 -LRB- kip1 -RRB- protein expression and spontaneous apoptosis in patients with colorectal_adenocarcinomas .
10766421	0	p27	15,18	kip1	19,23	p27	kip1	10671	1027	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of p27 -LRB- kip1 -RRB- in ceramide-mediated apoptosis in HL-60 cells .
10837916	0	p27	23,26	kip1	27,31	p27	kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and role of p27 -LRB- kip1 -RRB- in neuronal differentiation of embryonal_carcinoma cells .
10861499	0	p27	0,3	kip1	4,8	p27	kip1	3429	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p27 -LRB- kip1 -RRB- expression in breast_carcinomas : an immunohistochemical study on 512 patients with long-term follow-up .
10864486	0	p27	0,3	kip1	4,8	p27	kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p27 -LRB- kip1 -RRB- expression in rectal_cancer correlates with disease-free survival .
11420693	0	p27	74,77	kip1	78,82	p27	kip1	10671	1027	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27 -LRB- kip1 -RRB- levels .
11536304	0	p27	39,42	kip1	43,47	p27	kip1	3429	1027	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Methylation and mutational analysis of p27 -LRB- kip1 -RRB- in prostate_carcinoma .
11804875	0	p27	134,137	kip1	138,142	p27	kip1	3429	1027	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Interferon-gamma inhibits hepatocyte_growth_factor-stimulated cell proliferation of human bronchial epithelial cells : upregulation of p27 -LRB- kip1 -RRB- cyclin-dependent kinase inhibitor .
11967155	0	p27	30,33	kip1	34,38	p27	kip1	3429	1027	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	The COP9 signalosome inhibits p27 -LRB- kip1 -RRB- degradation and impedes G1-S phase progression via deneddylation of SCF Cul1 .
11969263	0	p27	98,101	kip1	102,106	p27	kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Deregulated expression of the homeobox gene Cux-1 in transgenic_mice results in downregulation of p27 -LRB- kip1 -RRB- expression during nephrogenesis , glomerular_abnormalities , and multiorgan hyperplasia .
15542603	3	p27	497,500	kip1	501,505	p27	kip1	10671	1027	Gene	Gene	shows|amod|START_ENTITY shows|appos|END_ENTITY	Here we show that p27 -LRB- kip1 -RRB- is not regulated by transcriptional control but that p27 -LRB- kip1 -RRB- protein shows increased stability after inhibition of the phosphoinositide -LRB- PI -RRB- 3-kinase pathway .
15654821	0	p27	78,81	kip1	82,86	p27	kip1	83571(Tax:10116)	83571(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mycophenolate_mofetil and roscovitine decrease cyclin expression and increase p27 -LRB- kip1 -RRB- expression in anti Thy1 mesangial proliferative nephritis .
15930262	0	p27	33,36	kip1	37,41	p27	kip1	3429	1027	Gene	Gene	stability|amod|START_ENTITY stability|appos|END_ENTITY	Tumor suppressor VDUP1 increases p27 -LRB- kip1 -RRB- stability by inhibiting JAB1 .
16022660	0	p27	0,3	kip1	4,8	p27	kip1	10534	1027	Gene	Gene	regulation|amod|START_ENTITY regulation|compound|END_ENTITY	p27 -LRB- kip1 -RRB- functional regulation in human cancer : a potential target for therapeutic designs .
16425184	0	p27	128,131	kip1	132,136	p27	kip1	10671	1027	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
16425184	0	p27	29,32	kip1	33,37	p27	kip1	10671	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	PI3K/Akt signaling regulates p27 -LRB- kip1 -RRB- expression via Skp2 in PC3 and DU145 prostate_cancer cells , but is not a major factor in p27 -LRB- kip1 -RRB- regulation in LNCaP and PC346 cells .
16740772	0	p27	194,197	kip1	198,202	p27	kip1	10671	1027	Gene	Gene	enhancement|amod|START_ENTITY enhancement|compound|END_ENTITY	Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal_clear_cell_carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation , cyclin-dependent_kinase_2 reduction , p27 -LRB- kip1 -RRB- enhancement , and disruption of binding to the extracellular matrix .
17031475	0	p27	82,85	kip1	86,90	p27	kip1	10534	1027	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27 -LRB- kip1 -RRB- translocation and retinoblastoma protein phosphorylation by 1 ' - acetoxychavicol_acetate .
17237771	0	p27	47,50	kip1	51,55	p27	kip1	10534	1027	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	The energy sensing LKB1-AMPK pathway regulates p27 -LRB- kip1 -RRB- phosphorylation mediating the decision to enter autophagy or apoptosis .
17448572	0	p27	63,66	kip1	67,71	p27	kip1	10671	1027	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Enhanced proteasome-dependent degradation of the CDK inhibitor p27 -LRB- kip1 -RRB- in immortalized lymphocytes from Alzheimer 's _ dementia patients .
18089324	0	p27	29,32	kip1	33,37	p27	kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A clinicopathologic study of p27 -LRB- kip1 -RRB- expression in renal allograft biopsy .
18598941	0	p27	67,70	kip1	71,75	p27	kip1	10534	1027	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Argyrin_a reveals a critical role for the tumor suppressor protein p27 -LRB- kip1 -RRB- in mediating antitumor activities in response to proteasome inhibition .
19273599	0	p27	48,51	kip1	52,56	p27	kip1	3429	1027	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	miR-181a regulates cap-dependent translation of p27 -LRB- kip1 -RRB- mRNA in myeloid cells .
19888978	0	p27	19,22	kip1	23,27	p27	kip1	10671	1027	Gene	Gene	EZH2|appos|START_ENTITY EZH2|appos|END_ENTITY	The value of EZH2 , p27 -LRB- kip1 -RRB- , BMI-1 and MIB-1 on biopsy specimens with low-risk prostate_cancer in selecting men with significant prostate_cancer at prostatectomy .
20193371	0	p27	40,43	kip1	44,48	p27	kip1	10534	1027	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Effects of transfected pIRES-p21 -LRB- waf1 -RRB- - p27 -LRB- kip1 -RRB- gene on the duplication of centrosomes and the proliferation of breast_cancer cell line MCF-7 -RSB- .
20923380	0	p27	25,28	kip1	29,33	p27	kip1	10534	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The relationship between p27 -LRB- kip1 -RRB- expression and the change of radiosensitivity of esophageal_carcinoma cells .
21734459	0	p27	20,23	kip1	24,28	p27	kip1	10671	1027	Gene	Gene	stability|amod|START_ENTITY stability|appos|END_ENTITY	Siah1/SIP regulates p27 -LRB- kip1 -RRB- stability and cell migration under metabolic stress .
22895010	0	p27	13,16	kip1	17,21	p27	kip1	10534	1027	Gene	Gene	light|nmod|START_ENTITY light|appos|END_ENTITY	New light on p27 -LRB- kip1 -RRB- in breast_cancer .
25015295	0	p27	49,52	kip1	53,57	p27	kip1	12576(Tax:10090)	12576(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Rho/ROCK pathway inhibition by the CDK inhibitor p27 -LRB- kip1 -RRB- participates in the onset of macrophage 3D-mesenchymal migration .
25323759	0	p27	34,37	kip1	38,42	p27	kip1	10534	1027	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of p27 -LRB- kip1 -RRB- in metastatic laryngeal_squamous_cell_carcinoma .
25536625	0	p27	70,73	kip1	74,78	p27	kip1	3429	1027	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Immunohistochemical expression of p53 , p63 , c-myc , p21 -LRB- WAF1/cip1 -RRB- and p27 -LRB- kip1 -RRB- proteins in urothelial_bladder_carcinoma : correlation with clinicopathological parameters .
26788203	0	p27	23,26	kip1	27,31	p27	kip1	10534	1027	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Expression of Skp2 and p27 -LRB- kip1 -RRB- proteins in hypopharyngeal_squamous_cell_carcinoma and its clinical significance .
9177226	0	p27	130,133	kip1	29,33	p27	kip1	3429	1027	Gene	Gene	expression|nmod|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|nmod|END_ENTITY	High level expression of p27 -LRB- kip1 -RRB- and cyclin_D1 in some human breast_cancer cells : inverse correlation between the expression of p27 -LRB- kip1 -RRB- and degree of malignancy_in_human_breast_and_colorectal_cancers .
9177226	0	p27	25,28	kip1	134,138	p27	kip1	3429	1027	Gene	Gene	kip1|amod|START_ENTITY expression|nmod|kip1 expression|dep|correlation correlation|nmod|expression expression|nmod|p27 p27|appos|END_ENTITY	High level expression of p27 -LRB- kip1 -RRB- and cyclin_D1 in some human breast_cancer cells : inverse correlation between the expression of p27 -LRB- kip1 -RRB- and degree of malignancy_in_human_breast_and_colorectal_cancers .
9784625	0	p27	59,62	kip1	63,67	p27	kip1	3429	1027	Gene	Gene	depletion|amod|START_ENTITY depletion|appos|END_ENTITY	cAMP inhibits linoleic_acid-induced growth by antagonizing p27 -LRB- kip1 -RRB- depletion , but not interfering with the extracellular signal-regulated kinase or AP-1 activities .
17395400	0	p27	54,57	mdm2	74,78	p27	mdm2	3429	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
16115229	0	p27	85,88	p14	90,93	p27	p14	10671	1029	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p27	54,57	p14	59,62	p27	p14	3429	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
10226946	0	p27	78,81	p16	63,66	p27	p16	3429	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
12960127	0	p27	27,30	p16	8,11	p27	p16	3429	1029	Gene	Gene	sequestration|amod|START_ENTITY contributes|nmod|sequestration contributes|nsubj|Loss Loss|nmod|END_ENTITY	Loss of p16 contributes to p27 sequestration by cyclin D -LRB- 1 -RRB- - cyclin-dependent kinase 4 complexes and poor prognosis in hepatocellular_carcinoma .
16115229	0	p27	85,88	p16	75,78	p27	p16	10671	1029	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
17395400	0	p27	54,57	p16	64,67	p27	p16	3429	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19624419	0	p27	62,65	p16	72,75	p27	p16	3429	1029	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
10329038	0	p27	75,78	p21	70,73	p27	p21	3429	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Aberrant expression of the cell cycle associated proteins TP53 , MDM2 , p21 , p27 , cdk4 , cyclin_D1 , RB , and EGFR in cervical_carcinomas .
11903579	0	p27	24,27	p21	35,38	p27	p21	3429	1026	Gene	Gene	examination|nmod|START_ENTITY allows|nmod|examination allows|nsubj|Waf1/Cip1 Waf1/Cip1|amod|END_ENTITY	Combined examination of p27 -LRB- Kip1 -RRB- , p21 -LRB- Waf1/Cip1 -RRB- and p53 expression allows precise estimation of prognosis in patients with gastric_carcinoma .
12713563	0	p27	60,63	p21	18,21	p27	p21	83571(Tax:10116)	24525(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Overexpression of p21 , cyclin_E and decreased expression of p27 in DMBA -LRB- 7 , _ 12-dimethylbenzanthracene -RRB- - induced rat ovarian_carcinogenesis .
14719078	0	p27	23,26	p21	18,21	p27	p21	3429	644914	Gene	Gene	E|amod|START_ENTITY E|amod|END_ENTITY	Protein levels of p21 , p27 , cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head_and_neck_squamous_cell_carcinomas .
16115229	0	p27	85,88	p21	80,83	p27	p21	10671	644914	Gene	Gene	molecules|nummod|START_ENTITY molecules|nummod|END_ENTITY	Expression and prognostic implications of cell cycle regulatory molecules , p16 , p21 , p27 , p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell_lymphomas .
16998811	0	p27	72,75	p21	83,86	p27	p21	3429	1026	Gene	Gene	p16|appos|START_ENTITY p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17088910	0	p27	16,19	p21	147,150	p27	p21	10671	644914	Gene	Gene	Upregulation|nmod|START_ENTITY dependent|nsubj|Upregulation dependent|nmod|expression expression|nmod|END_ENTITY	Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21 .
17395400	0	p27	54,57	p21	49,52	p27	p21	3429	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19624419	0	p27	62,65	p21	67,70	p27	p21	3429	1026	Gene	Gene	regulators|nummod|START_ENTITY regulators|nummod|END_ENTITY	Alterations of the cell cycle regulators cyclin_D1 , cyclin_A , p27 , p21 , p16 , and pRb in apocrine metaplasia of the breast .
20605638	0	p27	86,89	p21	81,84	p27	p21	83571(Tax:10116)	24525(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY ratio|amod|END_ENTITY	Inhibition of C6 rat glioma proliferation by -LSB- Ru2Cl -LRB- Ibp -RRB- 4 -RSB- depends on changes in p21 , p27 , Bax/Bcl2 ratio and mitochondrial membrane potential .
22468256	0	p27	29,32	p21	24,27	p27	p21	3429	644914	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
8033213	0	p27	0,3	p21	79,82	p27	p21	12576(Tax:10090)	12575(Tax:10090)	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	p27 , a novel inhibitor of G1 cyclin-Cdk protein kinase activity , is related to p21 .
10226946	0	p27	78,81	p53	73,76	p27	p53	3429	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
11706071	0	p27	18,21	p53	52,55	p27	p53	3429	7157	Gene	Gene	protein|amod|START_ENTITY protein|acl|combined combined|nmod|END_ENTITY	Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin_A and cyclin_B1 in diffuse_large_B-cell_lymphomas .
16998811	0	p27	72,75	p53	55,58	p27	p53	3429	7157	Gene	Gene	p16|appos|START_ENTITY analysis|appos|p16 analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17395400	0	p27	54,57	p53	69,72	p27	p53	3429	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19597334	0	p27	12,15	p53	7,10	p27	p53	12576(Tax:10090)	22060(Tax:10090)	Gene	Gene	failed|nsubj|START_ENTITY failed|nmod|END_ENTITY	Unlike p53 , p27 failed to exhibit an anti-tumor genetic interaction with Ku80 .
22468256	0	p27	29,32	p53	14,17	p27	p53	3429	7157	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
27033900	0	p27	123,126	p53	128,131	p27	p53	10671	7157	Gene	Gene	cells|amod|START_ENTITY cells|dep|END_ENTITY	Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27 , p53 , bcl-2 in canine breast_cancer cells .
22468256	0	p27	29,32	p63	19,22	p27	p63	3429	8626	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
10226946	0	p27	78,81	pRb	68,71	p27	pRb	3429	5925	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
24229711	0	p27	24,27	pRb	82,85	p27	pRb	3429	5925	Gene	Gene	safeguard|nsubj|START_ENTITY safeguard|ccomp|tumorigenesis tumorigenesis|nmod|absence absence|nmod|suppressors suppressors|compound|END_ENTITY	Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors .
12070150	0	p27	82,85	proto-oncogene_c-myc	4,24	p27	proto-oncogene c-myc	10671	4609	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The proto-oncogene_c-myc acts through the cyclin-dependent kinase -LRB- Cdk -RRB- inhibitor p27 -LRB- Kip1 -RRB- to facilitate the activation of Cdk4/6 and early G -LRB- 1 -RRB- phase progression .
19912438	0	p27	83,86	ribosomal_protein_S13	6,27	p27	ribosomal protein S13	3429	6207	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Human ribosomal_protein_S13 promotes gastric_cancer growth through down-regulating p27 -LRB- Kip1 -RRB- .
10772955	0	p27	99,102	skp2	86,90	p27	skp2	10671	6502	Gene	Gene	SCF|nmod|START_ENTITY SCF|appos|END_ENTITY	Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF -LRB- skp2 -RRB- toward p27 -LRB- kip1 -RRB- .
24229711	0	p27	24,27	tumor	94,99	p27	Pirh2	3429	25898	Gene	Gene	safeguard|nsubj|START_ENTITY safeguard|ccomp|tumorigenesis tumorigenesis|nmod|absence absence|nmod|suppressors suppressors|compound|END_ENTITY	Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors .
12421491	0	p27	39,42	tumor_necrosis_factor-alpha	46,73	p27	tumor necrosis factor-alpha	3429	7124	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The effect of cyclin kinase inhibitor p27 on tumor_necrosis_factor-alpha induced mesangial cell proliferation -RSB- .
20545441	0	p27	21,24	tumor_necrosis_factor_alpha	34,61	p27	tumor necrosis factor alpha	3429	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	Avian_leukosis virus p27 inhibits tumor_necrosis_factor_alpha expression in RAW264 .7 macrophages after stimulation with lipopolysaccharide .
15034923	0	p27KIP1	30,37	CK2	91,94	p27KIP1	CK2	1027	399320(Tax:8355)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2 .
11786086	0	p27KIP1	13,20	angiotensin_II	77,91	p27KIP1	angiotensin II	83571(Tax:10116)	24179(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY independent|nsubj|Induction independent|nmod|END_ENTITY	Induction of p27KIP1 after unilateral ureteral_obstruction is independent of angiotensin_II .
15271792	0	p27KIP1	27,34	cyclin	11,17	p27KIP1	cyclin	1027	5111	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	KSHV viral cyclin binds to p27KIP1 in primary effusion_lymphomas .
11035575	0	p27KIP1	98,105	cyclin_D1	71,80	p27KIP1	cyclin D1	1027	595	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Multiparameter immunohistochemical analysis of the cell cycle proteins cyclin_D1 , Ki-67 , p21WAF1 , p27KIP1 , and p53 in mantle_cell_lymphoma .
15029207	0	p27KIP1	21,28	cyclin_D1	43,52	p27KIP1	cyclin D1	1027	595	Gene	Gene	expression|amod|START_ENTITY impact|nmod|expression impact|nmod|lymphoproliferative_disorders lymphoproliferative_disorders|amod|END_ENTITY	Prognostic impact of p27KIP1 expression in cyclin_D1 positive lymphoproliferative_disorders .
18180298	0	p27KIP1	44,51	cyclin_D1	10,19	p27KIP1	cyclin D1	1027	595	Gene	Gene	binding|amod|START_ENTITY modulates|dobj|binding modulates|nsubj|mRNA mRNA|amod|END_ENTITY	Alternate cyclin_D1 mRNA splicing modulates p27KIP1 binding and cell migration .
24178620	0	p27KIP1	134,141	cyclin_D1	124,133	p27KIP1	cyclin D1	1027	595	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Antitumoral activity of lenalidomide in in vitro and in vivo models of mantle_cell_lymphoma involves the destabilization of cyclin_D1 / p27KIP1 complexes .
22142798	0	p27Kip1	60,67	AKT1	0,4	p27Kip1	AKT1	1027	207	Gene	Gene	cleavage|nmod|START_ENTITY induces|dobj|cleavage induces|nsubj|END_ENTITY	AKT1 induces caspase-mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD .
11010972	0	p27Kip1	70,77	BCR/ABL	0,7	p27Kip1	BCR/ABL	1027	25	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol_3-Kinase / AKT pathway .
16847309	0	p27Kip1	53,60	CDK2	62,66	p27Kip1	CDK2	12576(Tax:10090)	12566(Tax:10090)	Gene	Gene	ERK1/ERK2|compound|START_ENTITY ERK1/ERK2|dep|END_ENTITY	Docosahexaenoic_acid inhibits cancer cell growth via p27Kip1 , CDK2 , ERK1/ERK2 , and retinoblastoma phosphorylation .
17434927	0	p27Kip1	8,15	Cdk2	131,135	p27Kip1	Cdk2	12576(Tax:10090)	12566(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY enhances|nsubj|Loss enhances|nmod|tumorigenesis tumorigenesis|acl|ranging ranging|nmod|END_ENTITY	Loss of p27Kip1 enhances tumor progression in chronic hepatocyte injury-induced liver tumorigenesis with widely ranging effects on Cdk2 or Cdc2 activation .
8622924	0	p27Kip1	69,76	Cdk5	40,44	p27Kip1	Cdk5	12576(Tax:10090)	12568(Tax:10090)	Gene	Gene	escape|nmod|START_ENTITY allows|xcomp|escape allows|dobj|END_ENTITY	The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons .
9192873	0	p27Kip1	32,39	Cyclin	0,6	p27Kip1	Cyclin	12576(Tax:10090)	18538(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|E-CDK2 E-CDK2|compound|END_ENTITY	Cyclin E-CDK2 is a regulator of p27Kip1 .
9150381	0	p27Kip1	64,71	D1_and_D3	32,41	p27Kip1	D1 and D3	12576(Tax:10090)	13370;226695	Gene	Gene	inhibitor|dobj|START_ENTITY inhibitor|nsubj|control control|nmod|END_ENTITY	Differential control of cyclins D1_and_D3 and the cdk inhibitor p27Kip1 by diverse signalling pathways in Swiss_3T3 cells .
15713665	0	p27Kip1	14,21	E2F1	36,40	p27Kip1	E2F1	12576(Tax:10090)	13555(Tax:10090)	Gene	Gene	Expression|amod|START_ENTITY Activation|nmod|Expression Activation|nmod|END_ENTITY	Activation of p27Kip1 Expression by E2F1 .
12891709	0	p27Kip1	86,93	FoxO1	30,35	p27Kip1	FoxO1	83571(Tax:10116)	84482(Tax:10116)	Gene	Gene	transduces|nmod|START_ENTITY transduces|nsubj|END_ENTITY	Forkhead transcription factor FoxO1 transduces insulin-like growth factor 's signal to p27Kip1 in primary skeletal muscle satellite cells .
17894357	0	p27Kip1	30,37	FoxO3a	0,6	p27Kip1	FoxO3a	1027	2309	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	FoxO3a preferentially induces p27Kip1 expression while impairing muscle precursor cell-cycle progression .
11994454	0	p27Kip1	66,73	IL-2	97,101	p27Kip1	IL-2	1027	3558	Gene	Gene	transcription|nmod|START_ENTITY regulates|dobj|transcription regulates|nmod|END_ENTITY	The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2 .
20647308	0	p27Kip1	0,7	MYCC	54,58	p27Kip1	MYCC	1027	4609	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	p27Kip1 mediates addiction of ovarian_cancer cells to MYCC -LRB- c-MYC -RRB- and their dependence on MYC paralogs .
23824576	0	p27Kip1	93,100	Mcl1	0,4	p27Kip1	Mcl1	1027	4170	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Mcl1 regulates the terminal mitosis of neural_precursor_cells in the mammalian brain through p27Kip1 .
16982676	0	p27Kip1	85,92	Phox2a	33,39	p27Kip1	Phox2a	1027	401	Gene	Gene	transcription|amod|START_ENTITY induces|dobj|transcription induces|nsubj|END_ENTITY	Homeodomain transcription factor Phox2a , via cyclic_AMP-mediated activation , induces p27Kip1 transcription , coordinating neural progenitor cell cycle exit and differentiation .
19584057	0	p27Kip1	52,59	Pin1	0,4	p27Kip1	Pin1	12576(Tax:10090)	23988(Tax:10090)	Gene	Gene	Thr-187|nmod|START_ENTITY changes|nmod|Thr-187 catalyzes|dobj|changes catalyzes|nsubj|END_ENTITY	Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process .
18006823	0	p27Kip1	88,95	Pirh2	0,5	p27Kip1	Pirh2	1027	25898	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1 .
15980415	0	p27Kip1	18,25	SKP2	108,112	p27Kip1	SKP2	1027	6502	Gene	Gene	Ubiquitination|nmod|START_ENTITY requires|nsubj|Ubiquitination requires|nmod|E E|nmod|END_ENTITY	Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2 .
12401804	0	p27Kip1	76,83	Skp2	115,119	p27Kip1	Skp2	1027	6502	Gene	Gene	START_ENTITY|appos|role role|nmod|expression expression|amod|END_ENTITY	PAX3-FKHR transformation increases 26 S proteasome-dependent degradation of p27Kip1 , a potential role for elevated Skp2 expression .
12813041	0	p27Kip1	100,107	Skp2	35,39	p27Kip1	Skp2	1027	6502	Gene	Gene	interaction|nmod|START_ENTITY required|nmod|interaction required|nsubjpass|amino_acid amino_acid|nmod|END_ENTITY	A negatively charged amino_acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1 .
12904306	0	p27Kip1	24,31	Skp2	63,67	p27Kip1	Skp2	1027	6502	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Estrogens down-regulate p27Kip1 in breast_cancer cells through Skp2 and through nuclear export mediated by the ERK pathway .
15833859	0	p27Kip1	75,82	Skp2	34,38	p27Kip1	Skp2	1027	6502	Gene	Gene	degradation|amod|START_ENTITY promote|dobj|degradation induces|advcl|promote induces|dobj|expression expression|nmod|END_ENTITY	BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic_myelogenous_leukemia cells .
16537899	0	p27Kip1	45,52	Skp2	30,34	p27Kip1	Skp2	1027	6502	Gene	Gene	target|dobj|START_ENTITY associate|xcomp|target associate|nmod|END_ENTITY	Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome .
16774918	0	p27Kip1	97,104	Skp2	0,4	p27Kip1	Skp2	1027	6502	Gene	Gene	protects|nmod|START_ENTITY domain|acl:relcl|protects contains|dobj|domain contains|nsubj|END_ENTITY	Skp2 contains a novel cyclin_A binding domain that directly protects cyclin_A from inhibition by p27Kip1 .
16951165	0	p27Kip1	0,7	Skp2	85,89	p27Kip1	Skp2	12576(Tax:10090)	27401(Tax:10090)	Gene	Gene	repression|amod|START_ENTITY involves|nsubj|repression involves|dobj|END_ENTITY	p27Kip1 repression of ErbB2-induced mammary_tumor growth in transgenic_mice involves Skp2 and Wnt/beta-catenin signaling .
19351827	0	p27Kip1	90,97	Skp2	140,144	p27Kip1	Skp2	1027	6502	Gene	Gene	down-regulation|nmod|START_ENTITY activation|nmod|down-regulation induces|dobj|activation induces|nmod|association association|nmod|up-regulation up-regulation|nmod|END_ENTITY	Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1 , in association with the up-regulation of Skp2 and MiR-222 .
20407011	0	p27Kip1	51,58	Skp2	16,20	p27Kip1	Skp2	1027	6502	Gene	Gene	stabilization|amod|START_ENTITY promote|dobj|stabilization transcription|acl|promote transcription|amod|END_ENTITY	STAT1 represses Skp2 gene transcription to promote p27Kip1 stabilization in Ras-transformed cells .
12972555	0	p27Kip1	20,27	Spy1	0,4	p27Kip1	Spy1	1027	245711	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Spy1 interacts with p27Kip1 to allow G1/S progression .
9551912	0	p27Kip1	57,64	TGF-beta_1	0,10	p27Kip1	TGF-beta 1	12576(Tax:10090)	21803(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY induces|dobj|mRNA induces|nsubj|END_ENTITY	TGF-beta_1 induces the cyclin-dependent kinase inhibitor p27Kip1 mRNA and protein in murine B cells .
9671313	0	p27Kip1	38,45	TGFbeta3	12,20	p27Kip1	TGFbeta3	1027	7043	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Blockade of TGFbeta3 up-regulation of p27Kip1 and p21Cip1 by expression of RasN17 in epithelial cells .
16518840	0	p27Kip1	44,51	VDR	19,22	p27Kip1	VDR	1027	7421	Gene	Gene	activation|nmod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex .
9488039	0	p27Kip1	44,51	cdk2	18,22	p27Kip1	cdk2	1027	1017	Gene	Gene	inhibitor|amod|START_ENTITY sites|nmod|inhibitor sites|amod|END_ENTITY	Identification of cdk2 binding sites on the p27Kip1 cyclin-dependent kinase inhibitor .
11016654	0	p27Kip1	8,15	cyclin	21,27	p27Kip1	cyclin	1027	5111	Gene	Gene	START_ENTITY|nmod|_ _|amod|END_ENTITY	Loss of p27Kip1 from cyclin E/cyclin-dependent _ kinase _ -LRB- CDK -RRB- _ 2 but not from cyclin_D1 / CDK4 complexes in cells transformed by polyamine biosynthetic enzymes .
16774918	0	p27Kip1	97,104	cyclin_A	69,77	p27Kip1	cyclin A	1027	890	Gene	Gene	protects|nmod|START_ENTITY protects|dobj|END_ENTITY	Skp2 contains a novel cyclin_A binding domain that directly protects cyclin_A from inhibition by p27Kip1 .
11016654	0	p27Kip1	8,15	cyclin_D1	75,84	p27Kip1	cyclin D1	1027	595	Gene	Gene	_|amod|START_ENTITY Loss|nmod|_ _|nsubj|Loss _|nmod|complexes complexes|amod|END_ENTITY	Loss of p27Kip1 from cyclin E/cyclin-dependent _ kinase _ -LRB- CDK -RRB- _ 2 but not from cyclin_D1 / CDK4 complexes in cells transformed by polyamine biosynthetic enzymes .
12515730	0	p27Kip1	17,24	cyclin_D1	36,45	p27Kip1	cyclin D1	1027	595	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Sequestration of p27Kip1 protein by cyclin_D1 in typical and blastic variants of mantle_cell_lymphoma -LRB- MCL -RRB- : implications for pathogenesis .
15371458	0	p27Kip1	19,26	cyclin_D1	119,128	p27Kip1	cyclin D1	83571(Tax:10116)	58919(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY promotes|nsubj|Down-regulation promotes|dobj|proliferation proliferation|nmod|cardiomyocytes cardiomyocytes|acl|induced induced|nmod|expression expression|nmod|END_ENTITY	Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin_D1 and CDK4 .
17721077	0	p27Kip1	14,21	miRNA_221	25,34	p27Kip1	miRNA 221	1027	407006	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of p27Kip1 by miRNA_221 / 222 in glioblastoma .
25351256	0	p27Kip1	72,79	microRNA-429	18,30	p27Kip1	microRNA-429	1027	554210	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of microRNA-429 inhibits cell proliferation by targeting p27Kip1 in human prostate_cancer cells .
15868430	0	p27Kip1_and_decrease_in_retinoblastoma_protein	120,166	pRb	168,171	p27Kip1 and decrease in retinoblastoma protein	pRb	5925;1027	5925	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Inositol_hexaphosphate -LRB- IP6 -RRB- blocks proliferation of human breast_cancer cells through a PKCdelta-dependent increase in p27Kip1_and_decrease_in_retinoblastoma_protein -LRB- pRb -RRB- phosphorylation .
16532026	0	p27_Kip1	53,61	14-3-3sigma	30,41	p27 Kip1	14-3-3sigma	1027	2810	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Negative cell cycle regulator 14-3-3sigma stabilizes p27_Kip1 by inhibiting the activity of PKB/Akt .
18285702	0	p27_kip1	60,68	Jun_activation_domain-binding_protein_1	0,39	p27 kip1	Jun activation domain-binding protein 1	1027	10987	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	Jun_activation_domain-binding_protein_1 negatively regulate p27_kip1 in non-Hodgkin 's _ lymphomas .
16780593	0	p27kip1	33,40	Akt1	0,4	p27kip1	Akt1	1027	207	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical region .
16169901	0	p27kip1	82,89	CDKN1B	74,80	p27kip1	CDKN1B	1027	1027	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	The MLL fusion gene , MLL-AF4 , regulates cyclin-dependent kinase inhibitor CDKN1B -LRB- p27kip1 -RRB- expression .
16341208	0	p27kip1	35,42	Cdk5	0,4	p27kip1	Cdk5	12576(Tax:10090)	12568(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration .
26963853	0	p27kip1	95,102	Cks1	45,49	p27kip1	Cks1	1027	137529	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	TGF-b activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth .
24441545	0	p27kip1	117,124	ERK1/2	81,87	p27kip1	ERK1/2	83571(Tax:10116)	50689;116590	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1 .
16951171	0	p27kip1	85,92	Jun_activation_domain-binding_protein_1	18,57	p27kip1	Jun activation domain-binding protein 1	1027	10987	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|nmod|regulator	Potential role of Jun_activation_domain-binding_protein_1 as a negative regulator of p27kip1 in pancreatic_adenocarcinoma .
17428264	0	p27kip1	16,23	L-Maf	0,5	p27kip1	L-Maf	1027	395881(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	L-Maf regulates p27kip1 expression during chick lens fiber differentiation .
18794148	0	p27kip1	38,45	Pin1	23,27	p27kip1	Pin1	1027	5300	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors .
18719023	0	p27kip1	16,23	Skp2	84,88	p27kip1	Skp2	1027	6502	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nmod|down-regulation down-regulation|nmod|protein protein|amod|END_ENTITY	EGCG stabilizes p27kip1 in E2-stimulated MCF-7 cells through down-regulation of the Skp2 protein .
24441545	0	p27kip1	117,124	Skp2	62,66	p27kip1	Skp2	83571(Tax:10116)	294790(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Mechanisms in cardiac fibroblast growth : an obligate role for Skp2 and FOXO3a in ERK1/2 MAPK-dependent regulation of p27kip1 .
26963853	0	p27kip1	95,102	TGF-b	0,5	p27kip1	TGF-b	1027	7040	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	TGF-b activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth .
17631145	0	p27kip1	0,7	cdk2	18,22	p27kip1	cdk2	12576(Tax:10090)	12566(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium : potential role in neoplasia .
8780883	0	p27kip1	83,90	cyclin_D1	24,33	p27kip1	cyclin D1	1027	595	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|expression expression|nmod|END_ENTITY	Increased expression of cyclin_D1 in a murine mammary epithelial cell line induces p27kip1 , inhibits growth , and enhances apoptosis .
15240707	0	p28	86,89	IL-27	101,106	p28	IL-27	94189(Tax:10116)	365368(Tax:10116)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27 .
15528388	0	p28	101,104	IL-27	116,121	p28	IL-27	27061(Tax:10090)	246779(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27 .
23736031	0	p28	0,3	cop1	43,47	p28	cop1	9527	64326	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	p28 , a first in class peptide inhibitor of cop1 binding to p53 .
24062732	0	p28	66,69	p30	51,54	p28	p30	9527	201161	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	The need to accessorize : molecular roles of HTLV-1 p30 and HTLV-2 p28 accessory proteins in the viral life cycle .
25400040	0	p28	0,3	p300	26,30	p28	p300	9527	2033	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	p28 -LRB- GANK -RRB- associates with p300 to attenuate the acetylation of RelA .
23449360	0	p28	51,54	p53	97,100	p28	p53	9527	7157	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	A first-in-class , first-in-human , phase I trial of p28 , a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours .
18040287	0	p28_GANK	12,20	RelA	30,34	p28 GANK	RelA	5716	5970	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Oncoprotein p28_GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export .
15707960	0	p29	6,9	BAG-1	0,5	p29	BAG-1	25949	573	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	BAG-1 p29 protein prevents drug-induced cell death in the presence of EGF and enhances resistance to anoikis in SKOV3 human ovarian_cancer cells .
12750254	0	p29ING4	0,7	p53	28,31	p29ING4	p53	51147	7157	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|END_ENTITY	p29ING4 and p28ING5 bind to p53 and p300 , and enhance p53 activity .
21216954	0	p30	34,37	REGgamma	53,61	p30	REGgamma	201161	10197	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human_T-lymphotropic_virus_type_1 p30 interacts with REGgamma and modulates ATM _ -LRB- ataxia_telangiectasia_mutated -RRB- to promote cell survival .
8973570	0	p30	0,3	calcyclin	37,46	p30	calcyclin	15289(Tax:10090)	20200(Tax:10090)	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	p30 , a novel protein target of mouse calcyclin -LRB- S100A6 -RRB- .
8139016	0	p30	88,91	dUTPase	120,127	p30	dUTPase	201161	34529(Tax:7227)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Expression and purification of the mouse_mammary_tumor_virus gag-pro transframe protein p30 and characterization of its dUTPase activity .
2960408	0	p30	51,54	gag	42,45	p30	gag	15289(Tax:10090)	17276(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Human autoimmune serum antibodies against gag gene p30 retroviral protein also react with a U1-SnRNP 68K comigrant protein .
24062732	0	p30	51,54	p28	66,69	p30	p28	201161	9527	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	The need to accessorize : molecular roles of HTLV-1 p30 and HTLV-2 p28 accessory proteins in the viral life cycle .
11559821	0	p30	34,37	p300	103,107	p30	p300	201161	2033	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Human_T-lymphotropic_virus_type_1 p30 -LRB- II -RRB- regulates gene transcription by binding CREB_binding_protein / p300 .
22184527	0	p30	114,117	p42	103,106	p30	p42	201161	2038	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of sumoylation on the activities of CCAAT_enhancer_binding_protein_alpha -LRB- C/EBPa -RRB- p42 versus p30 may contribute in part , to aberrant C/EBPa activity in acute_leukemias .
14980493	0	p30	62,65	p54	67,70	p30	p54	201161	3433	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Neutralizing antibodies to African_swine_fever_virus proteins p30 , p54 , and p72 are not sufficient for antibody-mediated protection .
16024795	0	p300	23,27	Akt	0,3	p300	Akt	2033	207	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity .
9512516	0	p300	56,60	BETA2	35,40	p300	BETA2	328572(Tax:10090)	18012(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells .
19047049	0	p300	42,46	CD44	20,24	p300	CD44	2033	960	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast_tumor cells .
9826778	0	p300	149,153	COUP-TF_II	114,124	p300	COUP-TF II	328572(Tax:10090)	11819(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The orphan nuclear receptor , COUP-TF_II , inhibits myogenesis by post-transcriptional regulation of MyoD function : COUP-TF_II directly interacts with p300 and myoD .
9826778	0	p300	149,153	COUP-TF_II	29,39	p300	COUP-TF II	328572(Tax:10090)	11819(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY inhibits|parataxis|interacts inhibits|nsubj|receptor receptor|appos|END_ENTITY	The orphan nuclear receptor , COUP-TF_II , inhibits myogenesis by post-transcriptional regulation of MyoD function : COUP-TF_II directly interacts with p300 and myoD .
12461297	0	p300	39,43	CRD1	44,48	p300	CRD1	2033	1319	Gene	Gene	motif|amod|START_ENTITY motif|compound|END_ENTITY	Induction of transcription through the p300 CRD1 motif by p21WAF1/CIP1 is core promoter specific and cyclin dependent kinase independent .
10893273	0	p300	27,31	CREB-binding_protein	0,20	p300	CREB-binding protein	2033	1387	Gene	Gene	colocalize|amod|START_ENTITY /|dobj|colocalize /|nsubj|END_ENTITY	CREB-binding_protein -LRB- CBP -RRB- / p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus .
10944526	0	p300	21,25	CREB-binding_protein	0,20	p300	CREB-binding protein	2033	1387	Gene	Gene	activates|nsubj|START_ENTITY END_ENTITY|parataxis|activates	CREB-binding_protein / p300 activates MyoD by acetylation .
11509556	0	p300	62,66	CREB-binding_protein	41,61	p300	CREB-binding protein	2033	1387	Gene	Gene	required|nsubjpass|START_ENTITY Acetylation|parataxis|required Acetylation|nmod|END_ENTITY	Acetylation by histone acetyltransferase CREB-binding_protein / p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene .
11940575	0	p300	43,47	CREB-binding_protein	22,42	p300	CREB-binding protein	2033	1387	Gene	Gene	involvement|dep|START_ENTITY involvement|nmod|END_ENTITY	Direct involvement of CREB-binding_protein / p300 in sequence-specific DNA binding of virus-activated interferon_regulatory_factor-3 holocomplex .
11943779	0	p300	21,25	CREB-binding_protein	0,20	p300	CREB-binding protein	2033	1387	Gene	Gene	co-activation|amod|START_ENTITY END_ENTITY|dep|co-activation	CREB-binding_protein / p300 co-activation of crystallin gene expression .
15623506	0	p300	85,89	CREB-binding_protein	64,84	p300	CREB-binding protein	2033	1387	Gene	Gene	recruitment|amod|START_ENTITY recruitment|compound|END_ENTITY	Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding_protein / p300 recruitment .
15722556	0	p300	51,55	CREB-binding_protein	30,50	p300	CREB-binding protein	2033	1387	Gene	Gene	increase|amod|START_ENTITY chondrocyte|nsubj|increase END_ENTITY|parataxis|chondrocyte	Transcriptional Co-activators CREB-binding_protein / p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding _ protein .
16291753	0	p300	148,152	CREB-binding_protein	127,147	p300	CREB-binding protein	2033	1387	Gene	Gene	coactivator|amod|START_ENTITY coactivator|compound|END_ENTITY	A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding_protein / p300 coactivator .
17372613	0	p300	36,40	CREB-binding_protein	9,29	p300	CREB-binding protein	2033	1387	Gene	Gene	Roles|dep|START_ENTITY Roles|nmod|END_ENTITY	Roles of CREB-binding_protein -LRB- CBP -RRB- / p300 in respiratory epithelium tumorigenesis .
19880525	0	p300	163,167	CREB-binding_protein	142,162	p300	CREB-binding protein	2033	1387	Gene	Gene	START_ENTITY|amod|hypoxia-inducible_factor-1_alpha hypoxia-inducible_factor-1_alpha|nmod|interaction interaction|nmod|domains domains|nmod|/ /|amod|END_ENTITY	Complex regulation of the transactivation function of hypoxia-inducible_factor-1_alpha by direct interaction with two distinct domains of the CREB-binding_protein / p300 .
24338025	0	p300	81,85	CREB-binding_protein	54,74	p300	CREB-binding protein	2033	1387	Gene	Gene	proteins|nummod|START_ENTITY proteins|amod|END_ENTITY	NF-kB and enhancer-binding CREB protein scaffolded by CREB-binding_protein -LRB- CBP -RRB- / p300 proteins regulate CD59 protein expression to protect cells from complement attack .
9096323	0	p300	21,25	CREB-binding_protein	0,20	p300	CREB-binding protein	2033	1387	Gene	Gene	coactivators|nsubj|START_ENTITY END_ENTITY|parataxis|coactivators	CREB-binding_protein / p300 are transcriptional coactivators of p65 .
15075319	0	p300	114,118	ESE-1	83,88	p300	ESE-1	2033	1999	Gene	Gene	modulation|nmod|START_ENTITY modulation|nmod|END_ENTITY	Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300 , CREB-binding_protein , and Ku_70 / 86 .
16518544	0	p300	86,90	Ets2	22,26	p300	Ets2	2033	2114	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	Transcription factors Ets2 and Sp1 act synergistically with histone acetyltransferase p300 in activating human interleukin-12 p40 promoter .
19297328	0	p300	50,54	Fbw1a	29,34	p300	Fbw1a	2033	8945	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The F-box protein beta-TrCp1 / Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity .
15890677	0	p300	16,20	Foxo1	75,80	p300	Foxo1	2033	2308	Gene	Gene	acetylates|nsubj|START_ENTITY acetylates|dobj|END_ENTITY	The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription .
11978637	0	p300	75,79	GLUT2	87,92	p300	GLUT2	2033	6514	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter .
10846067	0	p300	17,21	Gps2	6,10	p300	Gps2	2033	2874	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	AMF-1 / Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins .
12408825	0	p300	103,107	ICAT	0,4	p300	ICAT	2033	56998	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules .
23670564	0	p300	0,4	IRF-1	38,43	p300	IRF-1	2033	3659	Gene	Gene	collaborates|nsubj|START_ENTITY collaborates|nmod|END_ENTITY	p300 , but not PCAF , collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity .
21278418	0	p300	13,17	MEF2	27,31	p300	MEF2	2033	4205	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly .
10944526	0	p300	21,25	MyoD	36,40	p300	MyoD	2033	4654	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	CREB-binding_protein / p300 activates MyoD by acetylation .
11463815	0	p300	70,74	MyoD	31,35	p300	MyoD	2033	4654	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between acetylated MyoD and the bromodomain of CBP and/or p300 .
14517256	0	p300	21,25	MyoD	93,97	p300	MyoD	328572(Tax:10090)	17927(Tax:10090)	Gene	Gene	acetyltransferase|amod|START_ENTITY role|nmod|acetyltransferase role|dep|acts acts|nmod|END_ENTITY	Differential role of p300 and CBP acetyltransferase during myogenesis : p300 acts upstream of MyoD and Myf5 .
14517256	0	p300	71,75	MyoD	93,97	p300	MyoD	328572(Tax:10090)	17927(Tax:10090)	Gene	Gene	acts|nummod|START_ENTITY acts|nmod|END_ENTITY	Differential role of p300 and CBP acetyltransferase during myogenesis : p300 acts upstream of MyoD and Myf5 .
8621548	0	p300	6,10	MyoD	65,69	p300	MyoD	2033	4654	Gene	Gene	protein|amod|START_ENTITY coactivator|nsubj|protein coactivator|nmod|END_ENTITY	Human p300 protein is a coactivator for the transcription factor MyoD .
9001254	0	p300	49,53	MyoD	104,108	p300	MyoD	2033	4654	Gene	Gene	coactivation|nmod|START_ENTITY mechanisms|nmod|coactivation mechanisms|dep|interaction interaction|nmod|domain domain|nmod|END_ENTITY	Molecular mechanisms of myogenic coactivation by p300 : direct interaction with the activation domain of MyoD and with the MADS box of MEF2C .
9826778	0	p300	149,153	MyoD	99,103	p300	MyoD	328572(Tax:10090)	17927(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY inhibits|parataxis|interacts inhibits|nmod|regulation regulation|nmod|function function|compound|END_ENTITY	The orphan nuclear receptor , COUP-TF_II , inhibits myogenesis by post-transcriptional regulation of MyoD function : COUP-TF_II directly interacts with p300 and myoD .
18472397	0	p300	18,22	Myostatin	0,9	p300	Myostatin	2033	2660	Gene	Gene	degradation|amod|START_ENTITY induces|dobj|degradation induces|nsubj|END_ENTITY	Myostatin induces p300 degradation to silence cyclin_D1 expression through the PI3K/PTEN/Akt pathway .
11268218	0	p300	26,30	PCNA	37,41	p300	PCNA	328572(Tax:10090)	18538(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis .
18263614	0	p300	89,93	PCNA	32,36	p300	PCNA	2033	5111	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|Interaction Interaction|nmod|p21 p21|nmod|END_ENTITY	Interaction of p21 -LRB- CDKN1A -RRB- with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair .
27032383	0	p300	12,16	PIAS1	0,5	p300	PIAS1	2033	8554	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status .
12379484	0	p300	52,56	PKCdelta	60,68	p300	PKCdelta	2033	5580	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Inhibition of histone acetyltransferase function of p300 by PKCdelta .
21357426	0	p300	26,30	Pax5	42,46	p300	Pax5	2033	5079	Gene	Gene	acetylates|nsubj|START_ENTITY acetylates|dobj|END_ENTITY	Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity .
17197080	0	p300	0,4	Presenilin_1	19,31	p300	Presenilin 1	2033	5663	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	p300 activation by Presenilin_1 but not by its M146L mutant .
9788595	0	p300	89,93	RelA	49,53	p300	RelA	2033	5970	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	p53-mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300 .
24636898	0	p300	0,4	RhoB	75,79	p300	RhoB	2033	388	Gene	Gene	cooperates|amod|START_ENTITY cooperates|nmod|c-Jun c-Jun|nmod|site site|nmod|END_ENTITY	p300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis .
24636898	0	p300	45,49	RhoB	75,79	p300	RhoB	2033	388	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	p300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis .
19423655	0	p300	15,19	Runx2	0,5	p300	Runx2	2033	860	Gene	Gene	recruits|xcomp|START_ENTITY recruits|nsubj|END_ENTITY	Runx2 recruits p300 to mediate parathyroid hormone 's effects on histone acetylation and transcriptional activation of the matrix_metalloproteinase-13 gene .
21239502	0	p300	46,50	SIRT-1	21,27	p300	SIRT-1	2033	23411	Gene	Gene	interactions|nmod|START_ENTITY interactions|compound|END_ENTITY	Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- activation of NF-kappaB signaling and inhibit osteoclastogenesis in bone-derived cells .
15632193	0	p300	38,42	SIRT1	0,5	p300	SIRT1	2033	23411	Gene	Gene	deacetylation|nmod|START_ENTITY deacetylation|compound|END_ENTITY	SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1 .
8855229	0	p300	71,75	SRC-1	41,46	p300	SRC-1	2033	8648	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The nuclear hormone receptor coactivator SRC-1 is a specific target of p300 .
18243116	0	p300	54,58	Skp2	0,4	p300	Skp2	2033	6502	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Skp2 suppresses p53-dependent apoptosis by inhibiting p300 .
18595660	0	p300	149,153	Smad2	0,5	p300	Smad2	2033	4087	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300 .
18595660	0	p300	149,153	Smad4	97,102	p300	Smad4	2033	4089	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300 .
19385047	0	p300	93,97	Smad4	103,108	p300	Smad4	2033	4089	Gene	Gene	preference|nmod|START_ENTITY switching|dobj|preference switching|nmod|END_ENTITY	TNF-alpha suppressed TGF-beta-induced CTGF expression by switching the binding preference of p300 from Smad4 to p65 .
25753752	0	p300	75,79	TAD2	38,42	p300	TAD2	2033	134637	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Characterization of the p300 Taz2-p53 TAD2 complex and comparison with the p300 Taz2-p53 TAD1 complex .
16179804	0	p300	0,4	TGF-beta	108,116	p300	TGF-beta	2033	7040	Gene	Gene	modulates|amod|START_ENTITY HIV-1|nsubj|modulates HIV-1|nmod|cells cells|acl|associated associated|nmod|alteration alteration|nmod|signaling signaling|compound|END_ENTITY	p300 modulates HIV-1 gp120-induced apoptosis in human proximal tubular cells : associated with alteration of TGF-beta and Smad signaling .
9813111	0	p300	8,12	TGF-beta	62,70	p300	TGF-beta	2033	7040	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of p300 , a transcriptional coactivator , in signalling of TGF-beta .
22415975	0	p300	30,34	TRAIL	44,49	p300	TRAIL	328572(Tax:10090)	22035(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	Sp1 , acetylated histone-3 and p300 regulate TRAIL transcription : mechanisms of PDGF-BB-mediated VSMC proliferation and migration .
10766811	0	p300	0,4	Tax	125,128	p300	Tax	2033	1491938(Tax:11908)	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	p300 and p300/cAMP-responsive element-binding protein associated factor interact with human_T-cell_lymphotropic_virus_type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex .
10899165	0	p300	70,74	Transcription_factor_ZBP-89	0,27	p300	Transcription factor ZBP-89	2033	7707	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Transcription_factor_ZBP-89 cooperates with histone acetyltransferase p300 during butyrate activation of p21waf1 transcription in human cells .
20385574	0	p300	124,128	c-Myb	57,62	p300	c-Myb	2033	4602	Gene	Gene	recruitment|amod|START_ENTITY recruitment|amod|END_ENTITY	A SUMO-regulated activation_function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment .
18570961	0	p300	34,38	c-Myc	53,58	p300	c-Myc	2033	4609	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	Simian_virus_40 large T overcomes p300 repression of c-Myc .
10327051	0	p300	115,119	c-jun	97,102	p300	c-jun	2033	3725	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	The N-terminal transactivation domain of ATF2 is a target for the co-operative activation of the c-jun promoter by p300 and 12S E1A .
11279135	0	p300	66,70	estrogen_receptor_alpha	26,49	p300	estrogen receptor alpha	2033	2099	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	Direct acetylation of the estrogen_receptor_alpha hinge region by p300 regulates transactivation and hormone sensitivity .
11430825	0	p300	104,108	flap_endonuclease-1	20,39	p300	flap endonuclease-1	2033	2237	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of human flap_endonuclease-1 activity by acetylation through the transcriptional coactivator p300 .
11313336	0	p300	13,17	interleukin-2	25,38	p300	interleukin-2	2033	3558	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Targeting of p300 to the interleukin-2 promoter via CREB-Rel cross-talk during mitogen and oncogenic molecular signaling in activated T-cells .
12384515	0	p300	0,4	interleukin_6	79,92	p300	interleukin 6	2033	3569	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	p300 mediates androgen-independent transactivation of the androgen_receptor by interleukin_6 .
25400040	0	p300	26,30	p28	0,3	p300	p28	2033	9527	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	p28 -LRB- GANK -RRB- associates with p300 to attenuate the acetylation of RelA .
11559821	0	p300	103,107	p30	34,37	p300	p30	2033	201161	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Human_T-lymphotropic_virus_type_1 p30 -LRB- II -RRB- regulates gene transcription by binding CREB_binding_protein / p300 .
15767673	0	p300	41,45	p38	71,74	p300	p38	2033	1432	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells .
10518217	0	p300	21,25	p53	45,48	p300	p53	2033	7157	Gene	Gene	START_ENTITY|acl:relcl|regulates regulates|dobj|response response|compound|END_ENTITY	A novel cofactor for p300 that regulates the p53 response .
11511361	0	p300	36,40	p53	57,60	p300	p53	2033	7157	Gene	Gene	activity|amod|START_ENTITY activity|nmod|response response|compound|END_ENTITY	A TPR motif cofactor contributes to p300 activity in the p53 response .
11591713	0	p300	13,17	p53	39,42	p300	p53	2033	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|stability stability|compound|END_ENTITY	Dual role of p300 in the regulation of p53 stability .
12499368	0	p300	66,70	p53	29,32	p300	p53	2033	7157	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|nmod|END_ENTITY	DNA-dependent acetylation of p53 by the transcription coactivator p300 .
12690203	0	p300	60,64	p53	22,25	p300	p53	2033	7157	Gene	Gene	activity|nmod|START_ENTITY ligase|dobj|activity ligase|nsubj|Polyubiquitination Polyubiquitination|nmod|END_ENTITY	Polyubiquitination of p53 by a ubiquitin ligase activity of p300 .
14612423	0	p300	83,87	p53	29,32	p300	p53	2033	7157	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|domain domain|nmod|END_ENTITY	The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53 .
15337767	0	p300	67,71	p53	111,114	p300	p53	2033	7157	Gene	Gene	binds|amod|START_ENTITY domain|nmod|binds homology|dobj|domain homology|nmod|peptides peptides|nmod|homology homology|nmod|domain domain|compound|END_ENTITY	The N-terminal interferon-binding domain -LRB- IBiD -RRB- homology domain of p300 binds to peptides with homology to the p53 transactivation domain .
15509808	0	p300	42,46	p53	87,90	p300	p53	2033	7157	Gene	Gene	stimulates|amod|START_ENTITY binding|nmod|stimulates acetylation|amod|binding acetylation|nmod|END_ENTITY	Interferon_regulatory_factor_1 binding to p300 stimulates DNA-dependent acetylation of p53 .
16229810	0	p300	27,31	p53	150,153	p300	p53	2033	7157	Gene	Gene	complex|amod|START_ENTITY activates|nsubj|complex activates|ccomp|Jun/Fos Jun/Fos|dobj|factors factors|dep|effects effects|nmod|END_ENTITY	An estrogen_receptor-alpha / p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors : repressive effects of p53 on BRCA-1 transcription .
17438265	0	p300	16,20	p53	97,100	p300	p53	2033	7157	Gene	Gene	START_ENTITY|nmod|sequence sequence|acl|spanning spanning|dobj|subdomains subdomains|nmod|END_ENTITY	Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53 .
18155245	0	p300	87,91	p53	70,73	p300	p53	2033	7157	Gene	Gene	domains|amod|START_ENTITY recognition|nmod|domains recognition|nmod|END_ENTITY	Differential recognition of phosphorylated transactivation domains of p53 by different p300 domains .
18612383	0	p300	19,23	p53	98,101	p300	p53	2033	7157	Gene	Gene	domain|nmod|START_ENTITY required|nsubjpass|domain required|xcomp|protect protect|nmod|downregulation downregulation|acl|induced induced|nmod|END_ENTITY	The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53 .
19166313	0	p300	85,89	p53	31,34	p300	p53	2033	7157	Gene	Gene	domain|nmod|START_ENTITY transactivation|nmod|domain transactivation|nsubj|motifs motifs|nmod|END_ENTITY	Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation .
19363523	0	p300	110,114	p53	102,105	p300	p53	2033	7157	Gene	Gene	domains|amod|START_ENTITY END_ENTITY|nmod|domains	Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2 .
21057544	0	p300	38,42	p53	14,17	p300	p53	2033	7157	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|acetylation acetylation|compound|END_ENTITY	p85a mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response .
21059157	0	p300	92,96	p53	41,44	p300	p53	2033	7157	Gene	Gene	decrease|amod|START_ENTITY accumulation|nmod|decrease accumulation|compound|END_ENTITY	SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease , eventually leading to apoptosis .
21513714	0	p300	45,49	p53	94,97	p300	p53	2033	7157	Gene	Gene	cooperate|nmod|START_ENTITY cooperate|xcomp|modulate modulate|dobj|activity activity|nmod|END_ENTITY	The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53 .
22074660	0	p300	108,112	p53	45,48	p300	p53	2033	7157	Gene	Gene	regulating|dobj|START_ENTITY inhibits|advcl|regulating inhibits|dobj|transactivation transactivation|nummod|END_ENTITY	Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300 .
23010591	0	p300	55,59	p53	81,84	p300	p53	2033	7157	Gene	Gene	features|nmod|START_ENTITY features|nmod|END_ENTITY	Structural features of human histone acetyltransferase p300 and its complex with p53 .
23796514	0	p300	40,44	p53	60,63	p300	p53	2033	7157	Gene	Gene	START_ENTITY|nmod|acetylation acetylation|amod|binding binding|nmod|END_ENTITY	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
23796514	0	p300	40,44	p53	79,82	p300	p53	2033	7157	Gene	Gene	START_ENTITY|nmod|acetylation acetylation|compound|END_ENTITY	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
26100016	0	p300	0,4	p53	46,49	p300	p53	328572(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p300 regulates liver functions by controlling p53 and C/EBP family proteins through multiple signaling pathways .
9094623	0	p300	0,4	p53	38,41	p300	p53	2033	7157	Gene	Gene	cosegregates|nsubj|START_ENTITY cosegregates|nmod|induction induction|compound|END_ENTITY	p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis .
9257185	0	p300	9,13	p53	102,105	p300	p53	2033	7157	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|activity activity|compound|END_ENTITY	Roles of p300 , pocket proteins , and hTBP in E1A-mediated transcriptional regulation and inhibition of p53 transactivation activity .
9652736	0	p300	62,66	p53	29,32	p300	p53	2033	7157	Gene	Gene	interplay|nmod|START_ENTITY interplay|nmod|END_ENTITY	Functional interplay between p53 and E2F through co-activator p300 .
9890940	0	p300	9,13	p53	34,37	p300	p53	2033	7157	Gene	Gene	START_ENTITY|nmod|stabilization stabilization|nmod|END_ENTITY	Role for p300 in stabilization of p53 in the response to DNA damage .
15965232	0	p300	0,4	p63	15,18	p300	p63	2033	8626	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	p300 regulates p63 transcriptional activity .
21057544	0	p300	38,42	p85a	0,4	p300	p85a	2033	5295	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	p85a mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response .
12095700	0	p300	29,33	peroxisome_proliferator-activated_receptor	53,95	p300	peroxisome proliferator-activated receptor	2033	5465	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Major intestinal coactivator p300 strongly activates peroxisome_proliferator-activated_receptor in intestinal cell line , Caco-2 .
9407140	0	p300	0,4	peroxisome_proliferator-activated_receptor_alpha	40,88	p300	peroxisome proliferator-activated receptor alpha	328572(Tax:10090)	19013(Tax:10090)	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	p300 functions as a coactivator for the peroxisome_proliferator-activated_receptor_alpha .
12937166	0	p300	83,87	proliferating_Cell_nuclear_antigen	10,44	p300	proliferating Cell nuclear antigen	2033	5111	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The human proliferating_Cell_nuclear_antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression .
21372295	0	p300	211,215	proline-rich_tyrosine_kinase	63,91	p300	proline-rich tyrosine kinase	328572(Tax:10090)	19229(Tax:10090)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Early inflammatory reactions in atherosclerosis are induced by proline-rich_tyrosine_kinase / reactive oxygen species-mediated release of tumor_necrosis_factor-alpha and subsequent activation of the p21Cip1/Ets -1 / p300 system .
15994976	0	p300	0,4	prostate-specific_antigen	59,84	p300	prostate-specific antigen	2033	354	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	p300 regulates androgen_receptor-independent expression of prostate-specific_antigen in prostate_cancer cells treated chronically with interleukin-6 .
10924503	0	p300	9,13	thyroperoxidase	36,51	p300	thyroperoxidase	2033	7173	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Role for p300 in Pax_8 induction of thyroperoxidase gene expression .
25091479	0	p32	0,3	Mcl-1	32,37	p32	Mcl-1	708	4170	Gene	Gene	START_ENTITY|appos|partner partner|nmod|END_ENTITY	p32 , a novel binding partner of Mcl-1 , positively regulates mitochondrial Ca -LRB- 2 + -RRB- uptake and apoptosis .
25528767	0	p32	14,17	Myc	36,39	p32	Myc	3622	4609	Gene	Gene	upregulated|nsubjpass|START_ENTITY upregulated|nmod|END_ENTITY	Mitochondrial p32 is upregulated in Myc expressing brain_cancers and mediates glutamine addiction .
22238231	0	p32	20,23	P150	53,57	p32	P150	708	10036	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Binding of cellular p32 protein to the rubella_virus P150 replicase protein via PxxPxR motifs .
25909887	0	p32	23,26	ULK1	37,41	p32	ULK1	708	8408	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Chaperone-like protein p32 regulates ULK1 stability and autophagy .
26001217	0	p32	23,26	ULK1	37,41	p32	ULK1	708	8408	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Chaperone-like protein p32 regulates ULK1 stability and autophagy .
11835353	0	p33	36,39	ING1	40,44	p33	ING1	3621	3621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression and sequence analyses of p33 -LRB- ING1 -RRB- gene in myeloid_leukemia .
24697598	0	p33	25,28	LL-37	61,66	p33	LL-37	3621	820	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability .
14630091	0	p33	0,3	estrogen_receptor_alpha	58,81	p33	estrogen receptor alpha	3621	2099	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	p33 -LRB- ING1b -RRB- stimulates the transcriptional activity of the estrogen_receptor_alpha via its activation_function -LRB- AF -RRB- 2 domain .
11076655	0	p33	42,45	p53	69,72	p33	p53	16994(Tax:10090)	22060(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY independent|nsubj|Expression independent|nmod|END_ENTITY	Expression of the novel tumour suppressor p33 -LRB- ING1 -RRB- is independent of p53 .
14642087	0	p33	42,45	p53	58,61	p33	p53	3621	7157	Gene	Gene	cooperation|nmod|START_ENTITY Study|nmod|cooperation Study|nmod|gene gene|compound|END_ENTITY	-LSB- Study of cooperation of tumor suppressor p33 -LRB- ING1b -RRB- with p53 gene in hepatocellular_carcinoma -RSB- .
9882325	0	p33	12,15	p53	28,31	p33	p53	3621	7157	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis .
17929852	0	p33ING1	22,29	alien	56,61	p33ING1	alien	3621	9318	Gene	Gene	interact|nsubj|START_ENTITY interact|nmod|END_ENTITY	The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing .
21896275	0	p33ING1b	21,29	p16INK4a	42,50	p33ING1b	p16INK4a	3621	1029	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence .
1297652	0	p33cdk2	18,25	Cyclin_A	0,8	p33cdk2	Cyclin A	1017	890	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Cyclin_A recruits p33cdk2 to the cellular transcription factor DRTF1 .
9268294	0	p34	104,107	APC	68,71	p34	APC	902	324	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of the tumor suppressor adenomatous_polyposis_coli -LRB- APC -RRB- by the cyclin-dependent kinase p34 .
1714386	0	p34	12,15	CDK2	32,36	p34	CDK2	79719	1017	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	A new human p34 protein kinase , CDK2 , identified by complementation of a cdc28 mutation in Saccharomyces_cerevisiae , is a homolog of Xenopus Eg1 .
12049736	0	p34	34,37	Cdc2	66,70	p34	Cdc2	902	983	Gene	Gene	Cdc2|amod|START_ENTITY tyrosine-15|nmod|Cdc2 Phosphorylation|nmod|tyrosine-15 inhibits|nsubj|Phosphorylation inhibits|dobj|activation activation|appos|END_ENTITY	Phosphorylation on tyrosine-15 of p34 -LRB- Cdc2 -RRB- by ErbB2 inhibits p34 -LRB- Cdc2 -RRB- activation and is involved in resistance to taxol-induced apoptosis .
12049736	0	p34	62,65	Cdc2	38,42	p34	Cdc2	902	983	Gene	Gene	activation|amod|START_ENTITY inhibits|dobj|activation inhibits|nsubj|Phosphorylation Phosphorylation|nmod|tyrosine-15 tyrosine-15|nmod|END_ENTITY	Phosphorylation on tyrosine-15 of p34 -LRB- Cdc2 -RRB- by ErbB2 inhibits p34 -LRB- Cdc2 -RRB- activation and is involved in resistance to taxol-induced apoptosis .
12049736	0	p34	62,65	Cdc2	66,70	p34	Cdc2	902	983	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Phosphorylation on tyrosine-15 of p34 -LRB- Cdc2 -RRB- by ErbB2 inhibits p34 -LRB- Cdc2 -RRB- activation and is involved in resistance to taxol-induced apoptosis .
8630339	0	p34	98,101	PCNA_and_3	120,130	p34	PCNA and 3	79719	5111	Gene	Gene	START_ENTITY|appos|-RSB- -RSB-|compound|END_ENTITY	Genesis and evolution of high-ploidy tumour cells evaluated by means of the proliferation markers p34 -LRB- cdc2 -RRB- , cyclin_B1 , PCNA_and_3 -LSB- H -RSB- - thymidine .
11420663	0	p34	58,61	cdc2	62,66	p34	cdc2	79719	983	Gene	Gene	p55Cdc|nmod|START_ENTITY upregulation|nmod|p55Cdc upregulation|appos|END_ENTITY	Transcriptional upregulation and activation of p55Cdc via p34 -LRB- cdc2 -RRB- in Taxol-induced apoptosis .
11466212	0	p34	111,114	cdc2	115,119	p34	cdc2	55379	983	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of phosphatidylinositol 3-kinase or mitogen-activated protein kinase kinase leads to suppression of p34 -LRB- cdc2 -RRB- kinase activity and meiotic progression beyond the meiosis I stage in porcine oocytes surrounded with cumulus cells .
11790456	0	p34	28,31	cdc2	32,36	p34	cdc2	66939(Tax:10090)	12534(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of instability of p34 -LRB- cdc2 -RRB- expression by treatment with cisplatin -LRB- CDDP -RRB- in mouse teratocarcinoma F9 cells .
12150824	0	p34	2,5	cdc2	6,10	p34	cdc2	66939(Tax:10090)	12534(Tax:10090)	Gene	Gene	survival|amod|START_ENTITY survival|compound|END_ENTITY	A p34 -LRB- cdc2 -RRB- survival checkpoint in cancer .
15539246	0	p34	101,104	cdc2	105,109	p34	cdc2	2967	983	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	R - -LRB- + -RRB- - perillyl_alcohol-induced cell cycle changes , altered actin cytoskeleton , and decreased ras and p34 -LRB- cdc2 -RRB- expression in colonic_adenocarcinoma SW480 cells .
16727806	0	p34	14,17	cdc2	18,22	p34	cdc2	2967	281061(Tax:9913)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Activation of p34 -LRB- cdc2 -RRB- kinase around the meiotic resumption in bovine oocytes cultured in vitro .
18181150	0	p34	139,142	cdc2	143,147	p34	cdc2	171435(Tax:10116)	54237(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	The anti-apoptosis protein , survivin , mediates gastric epithelial cell cytoprotection against ethanol-induced injury via activation of the p34 -LRB- cdc2 -RRB- cyclin-dependent kinase .
8910383	0	p34	32,35	cdc2	36,40	p34	cdc2	902	983	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|appos|END_ENTITY	Sequential dephosphorylation of p34 -LRB- cdc2 -RRB- on Thr-14 and Tyr-15 at the prophase/metaphase transition .
12973835	0	p34Cdc2	128,135	p21Cip1	66,73	p34Cdc2	p21Cip1	983	1026	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|compound|END_ENTITY	ErbB2 overexpression in human breast_carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2 : poor responsiveness to chemotherapy with cyclophoshamide_methotrexate , and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression .
2147872	0	p34cdc2	21,28	Cyclin	0,6	p34cdc2	Cyclin	380246(Tax:8355)	394328(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Cyclin activation of p34cdc2 .
9618275	0	p34cdc2	109,116	cyclin-dependent_kinase_1	82,107	p34cdc2	cyclin-dependent kinase 1	983	983	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Characterization of the enhancer-like okadaic_acid response element region of the cyclin-dependent_kinase_1 -LRB- p34cdc2 -RRB- promoter .
9164677	0	p34cdc2	198,205	cyclin_B1	188,197	p34cdc2	cyclin B1	983	891	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Mechanism of action of a tyrphostin , _ 3,4-dihydroxy-alpha-cyanothiocinnamamide , in breast_cancer cell growth inhibition involves the suppression of cyclin_B1 and the functional activity of cyclin_B1 / p34cdc2 complex .
2192260	0	p34cdc2	49,56	nucleolin	36,45	p34cdc2	nucleolin	983	4691	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Mitosis-specific phosphorylation of nucleolin by p34cdc2 protein kinase .
2141683	0	p34cdc2	19,26	p53	0,3	p34cdc2	p53	983	7157	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	p53 interacts with p34cdc2 in mammalian cells : implications for cell cycle control and oncogenesis .
2167834	0	p34cdc2	23,30	p53	0,3	p34cdc2	p53	12534(Tax:10090)	22060(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	p53 is associated with p34cdc2 in transformed cells .
2019567	1	p34cdc2	67,74	vimentin	90,98	p34cdc2	vimentin	983	7431	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	p34cdc2 phosphorylates vimentin at a unique N-terminal site .
2169348	0	p34cdc2	67,74	vimentin	94,102	p34cdc2	vimentin	983	7431	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin .
1850698	0	p34cdc2	48,55	wee1	61,65	p34cdc2	wee1	983	7465	Gene	Gene	START_ENTITY|nmod|manner manner|amod|END_ENTITY	Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1 + dependent manner .
25694605	0	p35	18,21	CDK-5	30,35	p35	CDK-5	8851	1020	Gene	Gene	localization|amod|START_ENTITY localization|compound|END_ENTITY	HSV-1 upregulates p35 , alters CDK-5 localization , and stimulates CDK-5 kinase activity during acute_infection in neurons .
17121855	0	p35	64,67	CDK5	49,53	p35	CDK5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Suppression Suppression|nmod|cleavage cleavage|nmod|activator activator|compound|END_ENTITY	Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation .
18325333	0	p35	15,18	CDK5	71,75	p35	CDK5	8851	1020	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|precursor precursor|nmod|END_ENTITY	CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5 .
19544209	0	p35	66,69	CDK5	50,54	p35	CDK5	396942(Tax:9823)	733700(Tax:9823)	Gene	Gene	genes|appos|START_ENTITY genes|amod|porcine porcine|dep|END_ENTITY	Cloning and spatio-temporal expression of porcine CDK5 and CDK5R1 -LRB- p35 -RRB- genes .
20181942	0	p35	0,3	CDK5	20,24	p35	CDK5	8851	1020	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nummod|END_ENTITY	p35 is required for CDK5 activation in cellular senescence .
25864429	0	p35	0,3	CDK5	79,83	p35	CDK5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	underlie|nsubj|START_ENTITY underlie|dobj|improvement improvement|acl|induced induced|nmod|silencing silencing|compound|END_ENTITY	p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing .
26444778	0	p35	86,89	CDK5	70,74	p35	CDK5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	Activator|appos|START_ENTITY Activator|compound|END_ENTITY	Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator , p35 , CDKR1 Protein .
9837783	0	p35	39,42	CDK5	60,64	p35	CDK5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|activator activator|nmod|END_ENTITY	Okadaic_acid-stimulated degradation of p35 , an activator of CDK5 , by proteasome in cultured neurons .
10604467	0	p35	14,17	Cdk5	37,41	p35	Cdk5	8851	1020	Gene	Gene	p25|nummod|START_ENTITY Conversion|nmod|p25 deregulates|nsubj|Conversion deregulates|dobj|activity activity|amod|END_ENTITY	Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration .
11331872	0	p35	12,15	Cdk5	48,52	p35	Cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	ERK induces p35 , a neuron-specific activator of Cdk5 , through induction of Egr1 .
12123804	0	p35	27,30	Cdk5	12,16	p35	Cdk5	8851	1020	Gene	Gene	levels|amod|START_ENTITY activator|dobj|levels activator|nsubj|survey survey|nmod|END_ENTITY	A survey of Cdk5 activator p35 and p25 levels in Alzheimer 's _ disease brains .
12230554	0	p35	58,61	Cdk5	85,89	p35	Cdk5	8851	1020	Gene	Gene	peptide|appos|START_ENTITY inhibits|nsubj|peptide inhibits|dobj|activity activity|amod|END_ENTITY	A peptide derived from cyclin-dependent kinase activator -LRB- p35 -RRB- specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells .
14521924	0	p35	57,60	Cdk5	42,46	p35	Cdk5	8851	1020	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein .
15816873	0	p35	84,87	Cdk5	38,42	p35	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	stability|amod|START_ENTITY Control|nmod|stability Control|nmod|activity activity|appos|END_ENTITY	Control of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity by glutamatergic regulation of p35 stability .
15992363	0	p35	54,57	Cdk5	48,52	p35	Cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	complexes|amod|START_ENTITY Activation|dep|complexes Activation|nmod|cyclin-dependent_kinase_5 cyclin-dependent_kinase_5|appos|END_ENTITY	Activation of latent cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- - p35 complexes by membrane dissociation .
17295212	0	p35	44,47	Cdk5	23,27	p35	Cdk5	8851	1020	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|presence presence|nmod|END_ENTITY	The presence of active Cdk5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte .
17491008	0	p35	40,43	Cdk5	57,61	p35	Cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	activator|amod|START_ENTITY association|nmod|activator association|nmod|END_ENTITY	Microtubule association of the neuronal p35 activator of Cdk5 .
17526058	0	p35	37,40	Cdk5	87,91	p35	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	derived|nmod|START_ENTITY Peptides|acl|derived inhibit|nsubj|Peptides inhibit|dobj|activity activity|nmod|END_ENTITY	Peptides derived from Cdk5 activator p35 , specifically inhibit deregulated activity of Cdk5 .
20081373	0	p35	56,59	Cdk5	87,91	p35	Cdk5	8851	1020	Gene	Gene	microcephaly|appos|START_ENTITY microcephaly|appos|END_ENTITY	The primary microcephaly 3 -LRB- MCPH3 -RRB- interacting protein , p35 and its catalytic subunit , Cdk5 , are centrosomal proteins .
20130526	0	p35	0,3	Cdk5	33,37	p35	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	p35 , the non-cyclin activator of Cdk5 , protects podocytes against apoptosis in vitro and in vivo .
20720012	0	p35	40,43	Cdk5	49,53	p35	Cdk5	8851	1020	Gene	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	A 24-residue peptide -LRB- p5 -RRB- , derived from p35 , the Cdk5 neuronal activator , specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation .
20976519	0	p35	13,16	Cdk5	30,34	p35	Cdk5	8851	1020	Gene	Gene	activator|amod|START_ENTITY activator|nmod|END_ENTITY	The neuronal p35 activator of Cdk5 is a novel F-actin binding and bundling protein .
21736731	0	p35	57,60	Cdk5	21,25	p35	Cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression inhibits|nmod|regulation inhibits|dobj|activity activity|amod|END_ENTITY	Resveratrol inhibits Cdk5 activity through regulation of p35 expression .
23038754	0	p35	25,28	Cdk5	32,36	p35	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	A truncated peptide from p35 , a Cdk5 activator , prevents Alzheimer 's _ disease phenotypes in model mice .
24085300	0	p35	90,93	Cdk5	70,74	p35	Cdk5	8851	1020	Gene	Gene	activators|amod|START_ENTITY basis|nmod|activators basis|nmod|stability stability|nmod|complexes complexes|amod|END_ENTITY	Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators .
24326517	0	p35	29,32	Cdk5	36,40	p35	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	START_ENTITY|appos|activator activator|amod|END_ENTITY	TFP5 , a peptide derived from p35 , a Cdk5 neuronal activator , rescues cortical neurons from glucose toxicity .
24755075	0	p35	71,74	Cdk5	28,32	p35	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY transcription|nmod|mRNA activity|nmod|transcription activity|amod|END_ENTITY	Valproic_acid downregulates Cdk5 activity via the transcription of the p35 mRNA .
26631721	0	p35	32,35	Cdk5	36,40	p35	Cdk5	8851	1020	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Two degradation pathways of the p35 Cdk5 activation subunit , dependent and independent of ubiquitination .
26961960	0	p35	116,119	Cdk5	149,153	p35	Cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|END_ENTITY	Cyclic_AMP and Polyamines Overcome Inhibition by Myelin-Associated_Glycoprotein through eIF5A-Mediated Increases in p35 Expression and Activation of Cdk5 .
8622924	0	p35	29,32	Cdk5	40,44	p35	Cdk5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	allows|nsubj|START_ENTITY allows|dobj|END_ENTITY	The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons .
9727024	0	p35	0,3	Cdk5	67,71	p35	Cdk5	8851	1020	Gene	Gene	START_ENTITY|appos|activator activator|nmod|cyclin-dependent_kinase_5 cyclin-dependent_kinase_5|appos|END_ENTITY	p35 , the neuronal-specific activator of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- is degraded by the ubiquitin-proteasome pathway .
11813240	0	p35	87,90	Cyclin-dependent_kinase_5	0,25	p35	Cyclin-dependent kinase 5	8851	1020	Gene	Gene	domains|nmod|START_ENTITY requires|nmod|domains requires|nsubj|activation activation|amod|END_ENTITY	Cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activation requires interaction with three domains of p35 .
12019323	0	p35	26,29	Cyclin-dependent_kinase_5	0,25	p35	Cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY END_ENTITY|parataxis|contributes	Cyclin-dependent_kinase_5 / p35 contributes synergistically with Reelin/Dab1 to the positioning of facial_branchiomotor_and_inferior_olive_neurons in the developing mouse hindbrain .
15908038	0	p35	37,40	Cyclin-dependent_kinase_5	0,25	p35	Cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	activators|amod|START_ENTITY activators|amod|END_ENTITY	Cyclin-dependent_kinase_5 activators p35 and p39 facilitate formation of functional synapses .
19362124	0	p35	36,39	Cyclin-dependent_kinase_5	0,25	p35	Cyclin-dependent kinase 5	8851	1020	Gene	Gene	over-expression|amod|START_ENTITY activator|dobj|over-expression activator|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 activator p35 over-expression and amyloid beta synergism increase apoptosis in cultured neuronal cells .
11331872	0	p35	12,15	ERK	0,3	p35	ERK	116671(Tax:10116)	24338(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	ERK induces p35 , a neuron-specific activator of Cdk5 , through induction of Egr1 .
12084709	0	p35	24,27	Pctaire1	0,8	p35	Pctaire1	12569(Tax:10090)	18555(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35 .
12056836	0	p35	26,29	Presenilin_1	45,57	p35	Presenilin 1	8851	5663	Gene	Gene	phosphorylates|amod|START_ENTITY END_ENTITY|nsubj|phosphorylates	Cyclin-dependent_kinase-5 / p35 phosphorylates Presenilin_1 to regulate carboxy-terminal fragment stability .
1447309	0	p35	16,19	annexin_I	21,30	p35	annexin I	25380(Tax:10116)	25380(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|dep|END_ENTITY	Localization of p35 -LRB- annexin_I , lipocortin_I -RRB- in normal adult rat kidney and during recovery from ischemia .
8999805	0	p35	164,167	caspase-1	22,31	p35	caspase-1	3592	834	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Spodoptera frugiperda caspase-1 , a novel insect death protease that cleaves the nuclear immunophilin FKBP46 , is the target of the baculovirus antiapoptotic protein p35 .
11260720	0	p35	71,74	caspase-8	61,70	p35	caspase-8	3592	841	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Covalent inhibition revealed by the crystal structure of the caspase-8 / p35 complex .
9422379	0	p35	60,63	cdk-5	25,30	p35	cdk-5	8851	1020	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Cyclin_D2 interacts with cdk-5 and modulates cellular cdk-5 / p35 activity .
9422379	0	p35	60,63	cdk-5	54,59	p35	cdk-5	8851	1020	Gene	Gene	activity|amod|START_ENTITY activity|amod|/ /|amod|END_ENTITY	Cyclin_D2 interacts with cdk-5 and modulates cellular cdk-5 / p35 activity .
10903889	0	p35	29,32	cdk5	14,18	p35	cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Processing Processing|nmod|activator activator|amod|END_ENTITY	Processing of cdk5 activator p35 to its truncated form -LRB- p25 -RRB- by calpain in acutely injured neuronal cells .
11813240	0	p35	87,90	cdk5	27,31	p35	cdk5	8851	1020	Gene	Gene	domains|nmod|START_ENTITY requires|nmod|domains requires|nsubj|activation activation|appos|END_ENTITY	Cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- activation requires interaction with three domains of p35 .
12393264	0	p35	109,112	cdk5	80,84	p35	cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	proteolysis|nmod|START_ENTITY Influence|nmod|proteolysis Influence|appos|END_ENTITY	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
12393264	0	p35	32,35	cdk5	80,84	p35	cdk5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY Influence|nmod|phosphorylation Influence|appos|END_ENTITY	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
10327200	0	p35	58,61	cyclin-dependent_kinase_5	14,39	p35	cyclin-dependent kinase 5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of cyclin-dependent_kinase_5 and its activator p35 in rat brain after middle_cerebral_artery_occlusion .
10748088	0	p35	46,49	cyclin-dependent_kinase_5	50,75	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent_kinase_5 activator to p25 .
11517264	0	p35	0,3	cyclin-dependent_kinase_5	30,55	p35	cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY essential|nmod|function function|amod|END_ENTITY	p35 and p39 are essential for cyclin-dependent_kinase_5 function during neurodevelopment .
12393264	0	p35	109,112	cyclin-dependent_kinase_5	53,78	p35	cyclin-dependent kinase 5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	proteolysis|nmod|START_ENTITY Influence|nmod|proteolysis Influence|nmod|phosphorylation phosphorylation|nmod|p35 p35|appos|activator activator|nmod|END_ENTITY	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
12393264	0	p35	32,35	cyclin-dependent_kinase_5	53,78	p35	cyclin-dependent kinase 5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Influence of phosphorylation of p35 , an activator of cyclin-dependent_kinase_5 -LRB- cdk5 -RRB- , on the proteolysis of p35 .
12558997	0	p35	58,61	cyclin-dependent_kinase_5	21,46	p35	cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	Stabilization of the cyclin-dependent_kinase_5 activator , p35 , by paclitaxel decreases beta-amyloid toxicity in cortical neurons .
12598607	0	p35	51,54	cyclin-dependent_kinase_5	55,80	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Developmental regulation of the proteolysis of the p35 cyclin-dependent_kinase_5 activator by phosphorylation .
14673209	0	p35	79,82	cyclin-dependent_kinase_5	18,43	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	Cdk5|amod|START_ENTITY metabolism|nmod|Cdk5 activity|nmod|metabolism activity|amod|END_ENTITY	The regulation of cyclin-dependent_kinase_5 activity through the metabolism of p35 or p39 Cdk5 activator .
15009685	0	p35	118,121	cyclin-dependent_kinase_5	78,103	p35	cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	causes|nmod|START_ENTITY causes|dobj|independent independent|nmod|activation activation|amod|END_ENTITY	Mutant superoxide dismutase 1 causes motor neuron_degeneration independent of cyclin-dependent_kinase_5 activation by p35 or p25 .
15289351	0	p35	89,92	cyclin-dependent_kinase_5	106,131	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	activator|amod|START_ENTITY activator|nmod|onset onset|amod|END_ENTITY	Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent_kinase_5 and consequent onset of the terminal phase of HL60 cell differentiation .
15695523	0	p35	63,66	cyclin-dependent_kinase_5	83,108	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Interferon_gamma induces neurite outgrowth by up-regulation of p35 neuron-specific cyclin-dependent_kinase_5 activator via activation of ERK1/2 pathway .
15816873	0	p35	84,87	cyclin-dependent_kinase_5	11,36	p35	cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	stability|amod|START_ENTITY Control|nmod|stability Control|nmod|activity activity|amod|END_ENTITY	Control of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- activity by glutamatergic regulation of p35 stability .
15917097	0	p35	65,68	cyclin-dependent_kinase_5	15,40	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	complex|amod|START_ENTITY activators|dobj|complex activators|nsubj|Association Association|acl|END_ENTITY	Association of cyclin-dependent_kinase_5 and neuronal activators p35 and p39 complex in early-onset Alzheimer 's _ disease .
15992363	0	p35	54,57	cyclin-dependent_kinase_5	21,46	p35	cyclin-dependent kinase 5	116671(Tax:10116)	140908(Tax:10116)	Gene	Gene	complexes|amod|START_ENTITY Activation|dep|complexes Activation|nmod|END_ENTITY	Activation of latent cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- - p35 complexes by membrane dissociation .
15994305	0	p35	82,85	cyclin-dependent_kinase_5	41,66	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	tau|nmod|START_ENTITY tau|nmod|complexed complexed|amod|END_ENTITY	Phosphorylation of FTDP-17 mutant tau by cyclin-dependent_kinase_5 complexed with p35 , p25 , or p39 .
19049962	0	p35	133,136	cyclin-dependent_kinase_5	38,63	p35	cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY signaling|nmod|activation pain|acl|signaling regulates|nmod|pain regulates|dobj|activity activity|amod|END_ENTITY	Tumor_necrosis_factor-alpha regulates cyclin-dependent_kinase_5 activity during pain signaling through transcriptional activation of p35 .
19638632	0	p35	114,117	cyclin-dependent_kinase_5	118,143	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	activator|amod|START_ENTITY activator|amod|END_ENTITY	Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent_kinase_5 activator .
20492361	0	p35	62,65	cyclin-dependent_kinase_5	36,61	p35	cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Actin interaction and regulation of cyclin-dependent_kinase_5 / p35 complex activity .
20518484	0	p35	102,105	cyclin-dependent_kinase_5	65,90	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	activators|amod|START_ENTITY activators|amod|END_ENTITY	Membrane association facilitates degradation and cleavage of the cyclin-dependent_kinase_5 activators p35 and p39 .
26966064	0	p35	146,149	cyclin-dependent_kinase_5	79,104	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Transforming_growth_factor-b1 induces cell cycle arrest by activating atypical cyclin-dependent_kinase_5 through up-regulation of Smad3-dependent p35 expression in human MCF10A mammary epithelial cells .
8090221	0	p35	0,3	cyclin-dependent_kinase_5	47,72	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	p35 is a neural-specific regulatory subunit of cyclin-dependent_kinase_5 .
9192293	0	p35	47,50	cyclin-dependent_kinase_5	76,101	p35	cyclin-dependent kinase 5	12569(Tax:10090)	12568(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY patterns|nmod|expression patterns|appos|subunit subunit|nmod|END_ENTITY	Temporal and spatial patterns of expression of p35 , a regulatory subunit of cyclin-dependent_kinase_5 , in the nervous system of the mouse .
9727024	0	p35	0,3	cyclin-dependent_kinase_5	40,65	p35	cyclin-dependent kinase 5	8851	1020	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	p35 , the neuronal-specific activator of cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- is degraded by the ubiquitin-proteasome pathway .
2976938	0	p35	72,75	p36	77,80	p35	p36	327662(Tax:9913)	282689(Tax:9913)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Predicted structure for the calcium-dependent membrane-binding proteins p35 , p36 , and p32 .
9887100	0	p35srj	19,25	HIF-1	87,92	p35srj	HIF-1	10370	3091	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Functional role of p35srj , a novel p300/CBP binding protein , during transactivation by HIF-1 .
8634333	0	p36	33,36	annexin_II	38,48	p36	annexin II	12306(Tax:10090)	12306(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Complete structure of the murine p36 -LRB- annexin_II -RRB- gene .
2138915	0	p36	50,53	calpactin_I_heavy_chain	55,78	p36	calpactin I heavy chain	12306(Tax:10090)	12306(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and chromosome assignment of the murine p36 -LRB- calpactin_I_heavy_chain -RRB- gene .
2976938	0	p36	77,80	p35	72,75	p36	p35	282689(Tax:9913)	327662(Tax:9913)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Predicted structure for the calcium-dependent membrane-binding proteins p35 , p36 , and p32 .
7957080	0	p36	26,29	p40MO15	0,7	p36	p40MO15	394356(Tax:8355)	399461(Tax:8355)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes .
2973411	0	p36	0,3	src	40,43	p36	src	302	6714	Gene	Gene	START_ENTITY|appos|substrate substrate|nmod|kinase kinase|compound|END_ENTITY	p36 , the major cytoplasmic substrate of src tyrosine protein kinase , binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix .
18974112	0	p37Ing1b	0,8	p53	60,63	p37Ing1b	p53	26356(Tax:10090)	22060(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis .
11605009	0	p38	17,20	AKT	79,82	p38	AKT	1432	207	Gene	Gene	feedback|amod|START_ENTITY regulates|nsubj|feedback regulates|dobj|activation activation|nmod|pathway pathway|compound|END_ENTITY	Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes .
16475687	0	p38	47,50	AKT	74,77	p38	AKT	5594	207	Gene	Gene	MAPK|amod|START_ENTITY MAPK|nmod|activation activation|compound|END_ENTITY	Sphinganine causes early activation of JNK and p38 MAPK and inhibition of AKT activation in HT-29 human colon_cancer cells .
17699753	0	p38	23,26	ATF2	40,44	p38	ATF2	26416(Tax:10090)	11909(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells .
11042204	0	p38	0,3	Akt	97,100	p38	Akt	1432	207	Gene	Gene	functions|amod|START_ENTITY functions|nmod|END_ENTITY	p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils .
11259436	0	p38	181,184	Akt	0,3	p38	Akt	1432	207	Gene	Gene	Subunit|nmod|START_ENTITY potential|nmod|Subunit stimulates|dobj|potential stimulates|nsubj|END_ENTITY	Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa_B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38 .
11387313	0	p38	23,26	Akt	0,3	p38	Akt	1432	207	Gene	Gene	signaling|amod|START_ENTITY down-regulation|nmod|signaling down-regulation|compound|END_ENTITY	Akt down-regulation of p38 signaling provides a novel mechanism of vascular_endothelial_growth_factor-mediated cytoprotection in endothelial cells .
12824193	0	p38	89,92	Akt	120,123	p38	Akt	5594	207	Gene	Gene	MAPK|amod|START_ENTITY activation|nmod|MAPK activation|nmod|pathway pathway|compound|END_ENTITY	Protein_kinase_C promotes apoptosis in LNCaP_prostate_cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway .
12914935	0	p38	33,36	Akt	52,55	p38	Akt	5594	207	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	IL-4 augments anisomycin-induced p38 activation via Akt pathway in a follicular_dendritic_cell -LRB- FDC -RRB- - like line .
12972603	0	p38	30,33	Akt	70,73	p38	Akt	1432	207	Gene	Gene	protein|amod|START_ENTITY activity|nmod|protein Regulation|nmod|activity kinase|nsubj|Regulation kinase|nmod|END_ENTITY	Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis .
15084475	0	p38	8,11	Akt	57,60	p38	Akt	1432	207	Gene	Gene	MAPK|amod|START_ENTITY Role|nmod|MAPK Role|nmod|activation activation|compound|END_ENTITY	Role of p38 MAPK and MAPKAPK-2 in angiotensin_II-induced Akt activation in vascular smooth muscle cells .
15381256	0	p38	4,7	Akt	26,29	p38	Akt	26416(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY regulates|nsubj|pathway regulates|dobj|END_ENTITY	The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis .
15848222	0	p38	120,123	Akt	0,3	p38	Akt	81649(Tax:10116)	24185(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY downstream|nmod|kinase regulates|parataxis|downstream regulates|nsubj|END_ENTITY	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells : function at a point downstream from p38 MAP kinase .
15980035	0	p38	0,3	Akt	85,88	p38	Akt	1432	207	Gene	Gene	START_ENTITY|acl:relcl|required required|nsubjpass|activation activation|nmod|pathway pathway|compound|END_ENTITY	p38 and EGF_receptor kinase-mediated activation of the phosphatidylinositol_3-kinase / Akt pathway is required for Zn2 + - induced cyclooxygenase-2 expression .
24650887	0	p38	209,212	Akt	214,217	p38	Akt	26416(Tax:10090)	11651(Tax:10090)	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
14597420	0	p38	14,17	BMP-2	37,42	p38	BMP-2	1432	650	Gene	Gene	Activation|nmod|START_ENTITY mediates|nsubj|Activation mediates|dobj|effects effects|compound|END_ENTITY	Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts .
18056716	0	p38	90,93	BMP-2	0,5	p38	BMP-2	26416(Tax:10090)	12156(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38 .
23518236	0	p38	52,55	BMP-2	29,34	p38	BMP-2	1432	650	Gene	Gene	kinase|amod|START_ENTITY expression|nmod|kinase expression|compound|END_ENTITY	Nanohydroxyapatite increases BMP-2 expression via a p38 MAP kinase dependent pathway in periodontal ligament cells .
26708156	0	p38	92,95	BMP-2	24,29	p38	BMP-2	1432	650	Gene	Gene	MAPK|amod|START_ENTITY chondrocytes|nmod|MAPK stimulation|nmod|chondrocytes stimulation|amod|driven driven|amod|END_ENTITY	Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK .
20307495	0	p38	58,61	Bcl-2	16,21	p38	Bcl-2	5594	596	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Hypoxia-induced Bcl-2 expression in endothelial cells via p38 MAPK pathway .
12589800	0	p38	17,20	Bcl10	55,60	p38	Bcl10	1432	8915	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	UV-light induces p38 MAPK-dependent phosphorylation of Bcl10 .
10364245	0	p38	56,59	C-reactive_protein	0,18	p38	C-reactive protein	1432	1401	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	C-reactive_protein inhibits chemotactic peptide-induced p38 mitogen-activated protein kinase activity and human neutrophil movement .
21933441	0	p38	29,32	CGRP	65,69	p38	CGRP	81649(Tax:10116)	24241(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	On the possible role of ERK , p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats .
23759594	0	p38	11,14	CIP1	53,57	p38	CIP1	1432	1026	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for p38 in transcriptional elongation of p21 -LRB- CIP1 -RRB- in response to Aurora_B inhibition .
12746433	0	p38	134,137	COX-2	238,243	p38	COX-2	1432	5743	Gene	Gene	kinase|amod|START_ENTITY activation|nmod|kinase mRNA|nmod|activation cascade|amod|mRNA cascade|dep|role role|dep|region region|nmod|mRNA mRNA|compound|END_ENTITY	T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade : role of distal sequences in the 3 ' - untranslated region of COX-2 mRNA .
12746433	0	p38	134,137	COX-2	85,90	p38	COX-2	1432	5743	Gene	Gene	kinase|amod|START_ENTITY activation|nmod|kinase mRNA|nmod|activation cascade|amod|mRNA cascade|appos|END_ENTITY	T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade : role of distal sequences in the 3 ' - untranslated region of COX-2 mRNA .
12871860	0	p38	0,3	COX-2	31,36	p38	COX-2	1432	5743	Gene	Gene	MAPK|compound|START_ENTITY mediate|nsubj|MAPK mediate|dobj|expression expression|compound|END_ENTITY	p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes .
14530261	0	p38	43,46	COX-2	86,91	p38	COX-2	5594	5743	Gene	Gene	MAPK|amod|START_ENTITY localization|nmod|MAPK Alterations|nmod|localization potentiates|nsubj|Alterations potentiates|dobj|expression expression|compound|END_ENTITY	Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells .
14665434	0	p38	0,3	COX-2	45,50	p38	COX-2	26416(Tax:10090)	17709(Tax:10090)	Gene	Gene	mediates|amod|START_ENTITY mediates|dep|END_ENTITY	p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes : implications for the actin cytoskeleton .
14742690	0	p38	62,65	COX-2	17,22	p38	COX-2	1432	4513	Gene	Gene	activation|amod|START_ENTITY stabilization|nmod|activation stabilization|compound|END_ENTITY	Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts .
15001457	0	p38	99,102	COX-2	142,147	p38	COX-2	1432	4513	Gene	Gene	pathway|amod|START_ENTITY cells|nmod|pathway expression|nmod|cells expression|dep|effects effects|nmod|coupling coupling|compound|END_ENTITY	HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway : effects on COX-2 / PGI-synthase coupling .
15056456	0	p38	61,64	COX-2	9,14	p38	COX-2	1432	5743	Gene	Gene	activation|nummod|START_ENTITY precede|dobj|activation precede|nsubj|expression expression|compound|END_ENTITY	Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex .
15735738	0	p38	69,72	COX-2	22,27	p38	COX-2	26416(Tax:10090)	19225(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY activation|nmod|kinase blocking|dobj|activation expression|acl|blocking expression|compound|END_ENTITY	-LSB- 6 -RSB- - Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol_ester-stimulated mouse skin .
16000872	0	p38	122,125	COX-2	36,41	p38	COX-2	1432	5743	Gene	Gene	MAP|compound|START_ENTITY kinase|nsubj|MAP inhibits|parataxis|kinase inhibits|dobj|expression expression|nmod|END_ENTITY	Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes -LRB- HaCaT -RRB- by inhibiting activation of AP-1 : p38 MAP kinase and JNK as potential upstream targets .
16054711	0	p38	49,52	COX-2	19,24	p38	COX-2	81649(Tax:10116)	26198(Tax:10116)	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Anisomycin induces COX-2 mRNA expression through p38 -LRB- MAPK -RRB- and CREB independent of small GTPases in intestinal epithelial cells .
17276891	0	p38	52,55	COX-2	75,80	p38	COX-2	81649(Tax:10116)	26198(Tax:10116)	Gene	Gene	modulating|nsubj|START_ENTITY modulating|dobj|expression expression|amod|END_ENTITY	Curcumin , a Curcuma longa constituent , acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis .
19145780	0	p38	0,3	COX-2	47,52	p38	COX-2	81649(Tax:10116)	29527(Tax:10116)	Gene	Gene	MAPK|compound|START_ENTITY contributes|nsubj|MAPK contributes|nmod|expression expression|compound|END_ENTITY	p38 MAPK contributes to angiotensin_II-induced COX-2 expression in aortic fibroblasts from normotensive and hypertensive rats .
19287971	0	p38	59,62	COX-2	28,33	p38	COX-2	1432	5743	Gene	Gene	activating|dobj|START_ENTITY Sulforaphane|advcl|activating Sulforaphane|dobj|expression expression|compound|END_ENTITY	Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells .
21388279	0	p38	32,35	COX-2	50,55	p38	COX-2	1432	4513	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Involvement of P2Y6_receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes .
24558308	0	p38	74,77	COX-2	42,47	p38	COX-2	1432	4513	Gene	Gene	suppressing|dobj|START_ENTITY inhibits|advcl|suppressing inhibits|dobj|expression expression|compound|END_ENTITY	Korean Red Ginseng water extract inhibits COX-2 expression by suppressing p38 in acrolein-treated human endothelial cells .
24875145	0	p38	90,93	COX-2	51,56	p38	COX-2	26416(Tax:10090)	19225(Tax:10090)	Gene	Gene	MAP|compound|START_ENTITY kinase|nsubj|MAP inhibits|parataxis|kinase inhibits|dobj|expression expression|nmod|END_ENTITY	Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin : p38 MAP kinase and JNK as potential targets .
15700318	0	p38	25,28	DDB2	42,46	p38	DDB2	1432	1643	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Potential attenuation of p38 signaling by DDB2 as a factor in acquired TNF resistance .
18806262	0	p38	4,7	DDB2	90,94	p38	DDB2	1432	1643	Gene	Gene	kinase|amod|START_ENTITY augments|nsubj|kinase augments|nmod|degradation degradation|compound|END_ENTITY	The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation .
14749532	0	p38	86,89	Dysferlin	0,9	p38	Dysferlin	26416(Tax:10090)	8291	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Dysferlin in a hyperCKaemic patient with caveolin_3 mutation and in C2C12 cells after p38 MAP kinase inhibition .
16138080	0	p38	27,30	EEA1	19,23	p38	EEA1	1432	8411	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Phosphorylation of EEA1 by p38 MAP kinase regulates mu_opioid_receptor endocytosis .
16785992	0	p38	41,44	EGF_receptor	74,86	p38	EGF receptor	1432	1956	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cisplatin induces PKB/Akt activation and p38 -LRB- MAPK -RRB- phosphorylation of the EGF_receptor .
19138820	0	p38	0,3	EGF_receptor	24,36	p38	EGF receptor	5594	1956	Gene	Gene	kinase|nummod|START_ENTITY controls|nsubj|kinase controls|dobj|downregulation downregulation|compound|END_ENTITY	p38 MAP kinase controls EGF_receptor downregulation via phosphorylation at Ser1046/1047 .
26535079	0	p38	12,15	EP2	0,3	p38	EP2	26416(Tax:10090)	19217(Tax:10090)	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|compound|END_ENTITY	EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells .
10103024	0	p38	34,37	ERK	46,49	p38	ERK	1432	5594	Gene	Gene	START_ENTITY|dep|JNK JNK|parataxis|END_ENTITY	Mitogen-activated protein kinase -LRB- p38 - , JNK - , ERK - -RRB- activation pattern induced by extracellular and intracellular singlet oxygen and UVA .
11294892	0	p38	61,64	ERK	48,51	p38	ERK	1432	5594	Gene	Gene	ratios|amod|START_ENTITY regulate|nmod|ratios regulate|dobj|END_ENTITY	Urokinase receptor and fibronectin regulate the ERK -LRB- MAPK -RRB- to p38 -LRB- MAPK -RRB- activity ratios that determine carcinoma cell proliferation or dormancy in vivo .
11829473	0	p38	20,23	ERK	15,18	p38	ERK	26416(Tax:10090)	26413(Tax:10090)	Gene	Gene	MAP|amod|START_ENTITY MAP|compound|END_ENTITY	Involvement of ERK , p38 MAP kinase , and PKC in MHC class II-mediated signal transduction in a resting B cell line .
16385547	0	p38	188,191	ERK	251,254	p38	ERK	1432	5594	Gene	Gene	pathway|amod|START_ENTITY proteins|nmod|pathway activation|nmod|proteins induce|nmod|activation induce|dep|and and|parataxis|END_ENTITY	Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF-kappaB/Rel proteins via the p38 mitogen-activated protein kinase pathway , and of the MEK-1 / ERK pathway .
17175457	0	p38	35,38	ERK	30,33	p38	ERK	81649(Tax:10116)	24338(Tax:10116)	Gene	Gene	cytokine|nsubj|START_ENTITY cytokine|nmod|evidence evidence|nmod|role role|nmod|END_ENTITY	In vitro evidence for role of ERK , p38 , and JNK in exocrine pancreatic cytokine production .
18655782	0	p38	41,44	ERK	87,90	p38	ERK	1432	5594	Gene	Gene	pathway|amod|START_ENTITY inhibitor|nmod|pathway activates|nsubj|inhibitor activates|dobj|kinases kinases|compound|END_ENTITY	SB203580 , a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes .
18956431	0	p38	49,52	ERK	30,33	p38	ERK	1432	5594	Gene	Gene	START_ENTITY|nsubj|activation activation|nmod|END_ENTITY	Stretch-induced activation of ERK in myocytes is p38 and calcineurin-dependent .
20398804	0	p38	50,53	ERK	0,3	p38	ERK	1432	5594	Gene	Gene	inhibitor|amod|START_ENTITY effectiveness|nmod|inhibitor reduces|dobj|effectiveness reduces|nsubj|activation activation|compound|END_ENTITY	ERK activation by GM-CSF reduces effectiveness of p38 inhibitor on inhibiting TNFalpha release .
22294037	0	p38	80,83	ERK	25,28	p38	ERK	1432	5594	Gene	Gene	activation|amod|START_ENTITY inhibits|dobj|activation MKP-1expression|acl:relcl|inhibits enhance|dobj|MKP-1expression increases|xcomp|enhance increases|dobj|activity activity|compound|END_ENTITY	Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-a .
24619413	0	p38	44,47	ERK	91,94	p38	ERK	5594	5594	Gene	Gene	kinases|amod|START_ENTITY kinases|appos|END_ENTITY	The mitogen-activated protein -LRB- MAP -RRB- kinases p38 and extracellular_signal-regulated_kinase -LRB- ERK -RRB- are involved in hepatocyte-mediated phenotypic switching in prostate_cancer cells .
25236495	0	p38	78,81	ERK	108,111	p38	ERK	5594	5594	Gene	Gene	pathway|amod|START_ENTITY activation|nmod|pathway activation|nmod|END_ENTITY	MDA-7 / IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis .
25573072	0	p38	159,162	ERK	154,157	p38	ERK	1432	5594	Gene	Gene	MAPKs|appos|START_ENTITY MAPKs|compound|END_ENTITY	Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung_adenocarcinoma cells through PP2A-regulated ERK , p38 MAPKs and Akt signaling pathways .
25943485	0	p38	120,123	ERK	67,70	p38	ERK	81649(Tax:10116)	24338(Tax:10116)	Gene	Gene	signals|dep|START_ENTITY signals|compound|END_ENTITY	Lipoxin_A4 attenuates radicular_pain possibly by inhibiting spinal ERK , JNK and NF-kB/p65 and cytokine signals , but not p38 , in a rat model of non-compressive_lumbar_disc_herniation .
14667935	0	p38	45,48	ERK1/2	84,90	p38	ERK1/2	5594	5595;5594	Gene	Gene	regulation|nmod|START_ENTITY kinase|nsubj|regulation kinase|dobj|END_ENTITY	Adenosine_A3_receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3 ' - kinase .
16535835	0	p38	94,97	ERK1/2	105,111	p38	ERK1/2	81649(Tax:10116)	50689;116590	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Effect on apoptosis of anterior pituitary induced by cadmium_chloride and its relations with p38 MAPK _ ERK1/2 passway -RSB- .
20428768	0	p38	131,134	ERK1/2	105,111	p38	ERK1/2	5594	5595;5594	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast_cancer cells .
24650887	0	p38	209,212	ERK1/2	194,200	p38	ERK1/2	26416(Tax:10090)	26417;26413	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY p-c-JUN_and_JNK|amod|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
9553146	0	p38	18,21	Erk	57,60	p38	Erk	1432	5594	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway .
25548290	0	p38	0,3	Fibulin_3	24,33	p38	Fibulin 3	1432	2202	Gene	Gene	Expression|amod|START_ENTITY Expression|compound|END_ENTITY	p38 MAPK Down-regulates Fibulin_3 Expression through Methylation of Gene Regulatory Sequences : ROLE IN MIGRATION AND INVASION .
8650547	0	p38	92,95	GADD153	80,87	p38	GADD153	1432	1649	Gene	Gene	Kinase|amod|START_ENTITY END_ENTITY|nmod|Kinase	Stress-induced phosphorylation and activation of the transcription factor CHOP -LRB- GADD153 -RRB- by p38 MAP Kinase .
2149862	0	p38	69,72	GAP43	44,49	p38	GAP43	81649(Tax:10116)	29423(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Ultrastructural double localization of B-50 / GAP43 and synaptophysin -LRB- p38 -RRB- in the neonatal and adult rat hippocampus .
11067915	0	p38	21,24	GATA-3	91,97	p38	GATA-3	26416(Tax:10090)	14462(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY kinase|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Cyclic_AMP activates p38 mitogen-activated protein kinase in Th2 cells : phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression .
17277157	0	p38	36,39	GATA-3	73,79	p38	GATA-3	1432	2625	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3 .
12637564	0	p38	50,53	GLUT4	32,37	p38	GLUT4	1432	6517	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis .
26432358	0	p38	63,66	GPER	56,60	p38	GPER	1432	2852	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Estrogen suppresses breast_cancer proliferation through GPER / p38 MAPK axis during hypoxia .
23751077	0	p38	63,66	Gadd45g	0,7	p38	Gadd45g	1432	10912	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression .
17204543	0	p38	125,128	HGF	107,110	p38	HGF	1432	3082	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|dep|roles	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF : the roles of p38 , ERK , and JNK MAPK signaling .
18434445	0	p38	82,85	HO-1	117,121	p38	HO-1	81649(Tax:10116)	24451(Tax:10116)	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage : p38 MAPK-dependent upregulation of HO-1 .
10446196	0	p38	11,14	HSP27	21,26	p38	HSP27	1432	3315	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|nummod|END_ENTITY	A role for p38 -LRB- MAPK -RRB- / HSP27 pathway in smooth muscle cell migration .
15848222	0	p38	120,123	HSP27	31,36	p38	HSP27	81649(Tax:10116)	24471(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY downstream|nmod|kinase regulates|parataxis|downstream regulates|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells : function at a point downstream from p38 MAP kinase .
15911090	0	p38	79,82	HSP27	0,5	p38	HSP27	1432	3315	Gene	Gene	modulation|nmod|START_ENTITY protects|nmod|modulation protects|nsubj|END_ENTITY	HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun .
17367746	0	p38	100,103	HSP27	20,25	p38	HSP27	1432	3315	Gene	Gene	pathway|amod|START_ENTITY implication|nmod|pathway Characterization|dep|implication Characterization|nmod|phosphorylation phosphorylation|nummod|END_ENTITY	Characterization of HSP27 phosphorylation induced by microtubule interfering agents : implication of p38 signalling pathway .
11710946	0	p38	49,52	HSP70	87,92	p38	HSP70	1432	3308	Gene	Gene	kinase|amod|START_ENTITY kinase|acl|regulated regulated|dobj|induction induction|nmod|END_ENTITY	Human keratinocytes respond to osmotic stress by p38 map kinase regulated induction of HSP70 and HSP27 .
9430735	0	p38	0,3	HSP70	68,73	p38	HSP70	5594	3308	Gene	Gene	activity|amod|START_ENTITY essential|nsubj|activity essential|nmod|induction induction|nmod|mRNAs mRNAs|nmod|END_ENTITY	p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells .
21115498	0	p38	91,94	Heme_oxygenase-1	0,16	p38	Heme oxygenase-1	81649(Tax:10116)	24451(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation induces|dobj|expression END_ENTITY|parataxis|induces	Heme_oxygenase-1 / carbon_monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1 .
17906111	0	p38	79,82	Hsp27	107,112	p38	Hsp27	81649(Tax:10116)	24471(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27 .
16790501	0	p38	93,96	Hsp70	125,130	p38	Hsp70	1432	3308	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27 .
22074828	0	p38	72,75	ICAM-1	57,63	p38	ICAM-1	1432	3383	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells .
11994432	0	p38	112,115	IL-10	34,39	p38	IL-10	1432	3586	Gene	Gene	protein|amod|START_ENTITY inhibition|nmod|protein involve|dobj|inhibition mechanism|acl:relcl|involve mechanism|nmod|suppression suppression|compound|END_ENTITY	Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa_B in primary human macrophages .
16935932	0	p38	82,85	IL-10	61,66	p38	IL-10	1432	3586	Gene	Gene	activation|amod|START_ENTITY suppression|nmod|activation suppression|compound|END_ENTITY	IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression .
17202341	0	p38	134,137	IL-10	0,5	p38	IL-10	1432	3586	Gene	Gene	MAPK|compound|START_ENTITY involvement|nmod|MAPK regulation|dep|involvement regulation|compound|END_ENTITY	IL-10 regulation by HIV-Tat in primary human monocytic cells : involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors .
20671651	0	p38	10,13	IL-10	40,45	p38	IL-10	1432	3586	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	High MAPK p38 activity and low level of IL-10 in intermittent_claudication as opposed to stable_angina .
22829768	0	p38	54,57	IL-10	73,78	p38	IL-10	1432	3586	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	The pore-forming toxin b hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity .
23901045	0	p38	168,171	IL-10	206,211	p38	IL-10	1432	3586	Gene	Gene	inhibition|nmod|START_ENTITY enhances|nsubj|inhibition enhances|dep|suppressing suppressing|dobj|END_ENTITY	Novel function for the p38-MK2 signaling pathway in circulating CD1c + -LRB- BDCA-1 + -RRB- myeloid dendritic cells from healthy donors and advanced cancer patients ; inhibition of p38 enhances IL-12 whilst suppressing IL-10 .
9551930	0	p38	85,88	IL-10	23,28	p38	IL-10	1432	3586	Gene	Gene	role|nmod|START_ENTITY Regulation|dep|role Regulation|nmod|synthesis synthesis|compound|END_ENTITY	Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha : role of the p38 and p42/44 mitogen-activated protein kinases .
14631115	0	p38	21,24	IL-1alpha	28,37	p38	IL-1alpha	1432	3552	Gene	Gene	role|nmod|START_ENTITY role|nmod|induction induction|compound|END_ENTITY	Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line .
15249725	0	p38	78,81	IL-2	0,4	p38	IL-2	1432	3558	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	IL-2 and IL-10 production by human CD4 + T cells is differentially regulated by p38 : mode of stimulation-dependent regulation of IL-2 .
10445852	0	p38	32,35	IL-6	51,55	p38	IL-6	1432	3569	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3 .
10620700	0	p38	12,15	IL-6	52,56	p38	IL-6	1432	3569	Gene	Gene	protein|amod|START_ENTITY role|nmod|protein kinase|nsubj|role kinase|nmod|production production|amod|END_ENTITY	The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha - or IL-1beta-stimulated rheumatoid synovial fibroblasts .
10762076	0	p38	100,103	IL-6	40,44	p38	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY role|nmod|kinase Regulation|dep|role Regulation|nmod|interleukin-6 interleukin-6|appos|END_ENTITY	Regulation of macrophage interleukin-6 -LRB- IL-6 -RRB- and IL-10 expression by prostaglandin_E2 : the role of p38 mitogen-activated protein kinase .
14634061	0	p38	68,71	IL-6	43,47	p38	IL-6	5594	3569	Gene	Gene	role|nmod|START_ENTITY production|dep|role production|compound|END_ENTITY	Acute ethanol exposure inhibits macrophage IL-6 production : role of p38 and ERK1/2 MAPK .
15034939	0	p38	87,90	IL-6	68,72	p38	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY synthesis|nmod|kinase synthesis|compound|END_ENTITY	Interleukin _ -LRB- IL -RRB- -17 enhances tumor_necrosis_factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts .
15769552	0	p38	90,93	IL-6	0,4	p38	IL-6	1432	3569	Gene	Gene	mitogen|amod|START_ENTITY depends|nmod|mitogen depends|nsubj|expression expression|compound|END_ENTITY	IL-6 expression induced by adenosine A2b receptor stimulation in U373 MG cells depends on p38 mitogen activated kinase and protein kinase C. Adenosine binds to a class of G-protein coupled receptors , which are further distinguished as A -LRB- 1 -RRB- , A -LRB- 2a -RRB- , A -LRB- 2b -RRB- and A -LRB- 3 -RRB- adenosine receptors .
16147857	0	p38	22,25	IL-6	70,74	p38	IL-6	5594	3569	Gene	Gene	kinase|nummod|START_ENTITY activates|dobj|kinase activates|xcomp|promote promote|dobj|induction induction|compound|END_ENTITY	Substance_P activates p38 mitogen-activated protein kinase to promote IL-6 induction in human dental pulp fibroblasts .
16197469	0	p38	94,97	IL-6	13,17	p38	IL-6	1432	3569	Gene	Gene	MAPK|amod|START_ENTITY regulated|nmod|MAPK regulated|nsubjpass|Induction Induction|nmod|END_ENTITY	Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-kappaB .
16272363	0	p38	27,30	IL-6	98,102	p38	IL-6	5594	3569	Gene	Gene	MAPKs|compound|START_ENTITY activation|nmod|MAPKs leads|nsubj|activation leads|nmod|overexpression overexpression|compound|END_ENTITY	Constitutive activation of p38 and ERK1/2 MAPKs in epithelial cells of myasthenic thymus leads to IL-6 and RANTES overexpression : effects on survival and migration of peripheral T and B cells .
16571868	0	p38	28,31	IL-6	46,50	p38	IL-6	5594	3569	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia .
17204543	0	p38	125,128	IL-6	76,80	p38	IL-6	1432	3569	Gene	Gene	roles|nmod|START_ENTITY HGF|dep|roles decreasing|dobj|HGF MAPK|csubj|decreasing stimulates|advcl|MAPK stimulates|dobj|production production|nmod|END_ENTITY	Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF : the roles of p38 , ERK , and JNK MAPK signaling .
17825250	0	p38	64,67	IL-6	45,49	p38	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY synthesis|nmod|kinase synthesis|compound|END_ENTITY	Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts .
18025155	0	p38	97,100	IL-6	43,47	p38	IL-6	1432	3569	Gene	Gene	MAPK|amod|START_ENTITY macrophages|nmod|MAPK production|nmod|macrophages production|compound|END_ENTITY	Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp -RCB- B activity .
20631726	0	p38	47,50	IL-6	38,42	p38	IL-6	1432	3569	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells , similar to that seen in the psoriatic_condition .
21161531	0	p38	14,17	IL-6	98,102	p38	IL-6	5594	3569	Gene	Gene	MAPkinase|compound|START_ENTITY Inhibitors|nmod|MAPkinase block|nsubj|Inhibitors block|dobj|expression expression|amod|END_ENTITY	Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen_sulphide block constitutive and IL-1b-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28 / I2 .
23177780	0	p38	79,82	IL-6	0,4	p38	IL-6	1432	3569	Gene	Gene	pathway|amod|START_ENTITY promotes|nmod|pathway promotes|nsubj|END_ENTITY	IL-6 promotes the expression of vascular_endothelial_growth_factor through the p38 signalling pathway in hypertrophied adenoids in children .
23206705	0	p38	0,3	IL-6	41,45	p38	IL-6	1432	3569	Gene	Gene	alpha|amod|START_ENTITY mediates|nsubj|alpha mediates|dobj|END_ENTITY	p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac_fibroblasts .
23438872	0	p38	69,72	IL-6	48,52	p38	IL-6	81649(Tax:10116)	24498(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY release|nmod|pathway release|compound|END_ENTITY	High fatty_acids modulate P2X -LRB- 7 -RRB- expression and IL-6 release via the p38 MAPK pathway in PC12 cells .
24227780	0	p38	48,51	IL-6	27,31	p38	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	BANK1 controls CpG-induced IL-6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway .
24650887	0	p38	209,212	IL-6	138,142	p38	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	p-c-JUN_and_JNK|amod|START_ENTITY secretion|amod|p-c-JUN_and_JNK secretion|compound|END_ENTITY	Kolaviron , a natural flavonoid from the seeds of Garcinia kola , reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion , and inflammatory transcription factors , ERK1/2 , NF-kB , p38 , Akt , p-c-JUN_and_JNK .
26760196	0	p38	88,91	IL-6	109,113	p38	IL-6	81649(Tax:10116)	24498(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Hydrogen_sulfide prevents OGD/R-induced apoptosis by suppressing the phosphorylation of p38 and secretion of IL-6 in PC12 cells .
26733204	0	p38	118,121	Interleukin-17A	0,15	p38	Interleukin-17A	1432	3605	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 MAPK Pathway .
11709198	0	p38	170,173	JNK	209,212	p38	JNK	5594	5599	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Potentiation of cadmium-induced cytotoxicity by sulfur amino_acid deprivation through activation of extracellular_signal-regulated_kinase1 / 2 -LRB- ERK1/2 -RRB- in conjunction with p38 kinase or c-jun_N-terminal_kinase -LRB- JNK -RRB- .
21986805	0	p38	119,122	JNK	124,127	p38	JNK	81649(Tax:10116)	116554(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Mimosine-induced apoptosis in C6_glioma cells requires the release of mitochondria-derived reactive oxygen species and p38 , JNK activation .
14736735	0	p38	62,65	Jun_N-terminal_kinase	39,60	p38	Jun N-terminal kinase	5594	5599	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Extracellular signal-regulated kinase , Jun_N-terminal_kinase , p38 , and c-Src are involved in gonadotropin-releasing hormone-stimulated activity of the glycoprotein hormone follicle-stimulating hormone beta-subunit promoter .
23549267	0	p38	48,51	Kinase_Activation_and_Tumor_Necrosis_Factor-Alpha	78,127	p38	Kinase Activation and Tumor Necrosis Factor-Alpha	1432	7124	Gene	Gene	Expression|amod|START_ENTITY Expression|compound|END_ENTITY	A Role for Protein Phosphatase 2A in Regulating p38 Mitogen Activated Protein Kinase_Activation_and_Tumor_Necrosis_Factor-Alpha Expression during Influenza Virus_Infection .
22511272	0	p38	33,36	Krox-20	47,54	p38	Krox-20	81649(Tax:10116)	114090(Tax:10116)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination .
15979653	0	p38	41,44	Leptin	0,6	p38	Leptin	81649(Tax:10116)	25608(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells .
12943808	0	p38	108,111	MAPK	112,116	p38	MAPK	5594	5594	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Sphingosine-1-phosphate stimulates smooth muscle cell migration through galpha -LRB- i -RRB- - and pi3-kinase-dependent p38 -LRB- MAPK -RRB- activation .
11042204	0	p38	0,3	MAPKAPK-2	21,30	p38	MAPKAPK-2	1432	9261	Gene	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils .
15159407	0	p38	24,27	MEKK1	0,5	p38	MEKK1	1432	4214	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis .
19427893	0	p38	31,34	MKK3	0,4	p38	MKK3	26416(Tax:10090)	26397(Tax:10090)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	MKK3 , an upstream activator of p38 , contributes to formalin phase 2 and late allodynia in mice .
18573614	0	p38	85,88	MKP-1	29,34	p38	MKP-1	81649(Tax:10116)	114856(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|compound|END_ENTITY	Cadmium specifically induces MKP-1 expression via the glutathione depletion-mediated p38 MAPK activation in C6 glioma cells .
16549373	0	p38	75,78	MMP-1	44,49	p38	MMP-1	1432	4312	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells : potential role of Runx2 in mediating p38 effects .
19590887	0	p38	47,50	MMP-2	26,31	p38	MMP-2	5594	4313	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Mechanical force enhances MMP-2 activation via p38 signaling pathway in human retinal_pigment_epithelial cells .
20607722	0	p38	37,40	MMP-2	19,24	p38	MMP-2	1432	4313	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal_carcinoma cell invasion .
11468147	0	p38	113,116	MMP-9	35,40	p38	MMP-9	1432	4318	Gene	Gene	kinase|amod|START_ENTITY inhibition|nmod|kinase abolished|nmod|inhibition production|acl:relcl|abolished production|amod|cytopathogenic cytopathogenic|amod|END_ENTITY	HIV-1 glycoprotein_120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway .
11716547	0	p38	4,7	MMP-9	53,58	p38	MMP-9	1432	4318	Gene	Gene	SAPK|amod|START_ENTITY regulates|nsubj|SAPK regulates|dobj|expression expression|nmod|collagenase collagenase|compound|END_ENTITY	The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation .
14631115	0	p38	21,24	MMP-9	51,56	p38	MMP-9	1432	4318	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Differential role of p38 in IL-1alpha induction of MMP-9 and MMP-13 in an established liver myofibroblast cell line .
15483673	0	p38	41,44	MMP-9	61,66	p38	MMP-9	1432	4318	Gene	Gene	activation|nmod|START_ENTITY critical|nsubj|activation critical|nmod|production production|compound|END_ENTITY	Constitutive activation of the MAPkinase p38 is critical for MMP-9 production and survival of B-CLL cells on bone marrow stromal cells .
18801463	0	p38	76,79	MMP-9	40,45	p38	MMP-9	1432	4318	Gene	Gene	MAP|compound|START_ENTITY mediation|nmod|MAP pathway|dep|mediation pathway|nmod|expression expression|compound|END_ENTITY	Signaling pathway for TNF-alpha-induced MMP-9 expression : mediation through p38 MAP kinase , and inhibition by anti-cancer molecule magnolol in human urinary_bladder_cancer 5637 cells .
19576641	0	p38	74,77	MMP-9	23,28	p38	MMP-9	1432	4318	Gene	Gene	activation|amod|START_ENTITY prevention|nmod|activation reduces|nmod|prevention reduces|dobj|expression expression|compound|END_ENTITY	Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages .
22812390	0	p38	119,122	MMP-9	93,98	p38	MMP-9	1432	4318	Gene	Gene	pathway|amod|START_ENTITY regulation|nmod|pathway regulation|nmod|END_ENTITY	Fibronectin-a4b1 interactions in hepatic cold ischemia and reperfusion injury : regulation of MMP-9 and MT1-MMP via the p38 MAPK pathway .
22820569	0	p38	10,13	MMP-9	36,41	p38	MMP-9	81649(Tax:10116)	81687(Tax:10116)	Gene	Gene	signal|amod|START_ENTITY lowers|nsubj|signal lowers|dobj|expression expression|compound|END_ENTITY	-LSB- Blocking p38 signal pathway lowers MMP-9 expression and reduces brain_edema in rats with traumatic_brain_injury -RSB- .
23229870	0	p38	53,56	MMP-9	20,25	p38	MMP-9	1432	4318	Gene	Gene	kinase|amod|START_ENTITY migration|nmod|kinase migration|compound|END_ENTITY	Resveratrol induces MMP-9 and cell migration via the p38 kinase and PI-3K pathways in HT1080 human fibrosarcoma cells .
23468369	0	p38	15,18	MMP-9	47,52	p38	MMP-9	1432	4318	Gene	Gene	Involvement|nmod|START_ENTITY MAPK|nsubj|Involvement MAPK|nmod|enhancement enhancement|compound|END_ENTITY	Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes .
24819308	0	p38	83,86	MMP-9	58,63	p38	MMP-9	1432	4318	Gene	Gene	pathway|amod|START_ENTITY enhances|nmod|pathway enhances|dobj|invasion invasion|nmod|expression expression|compound|END_ENTITY	SDF-1 / CXCR7 axis enhances ovarian_cancer cell invasion by MMP-9 expression through p38 MAPK pathway .
25449697	0	p38	86,89	MMP-9	25,30	p38	MMP-9	5594	4318	Gene	Gene	pathways|compound|START_ENTITY /|nmod|pathways /|nsubj|up-regulates up-regulates|amod|END_ENTITY	Aldosterone up-regulates MMP-9 and MMP-9 / NGAL expression in human neutrophils through p38 , ERK1/2 and PI3K pathways .
14739931	0	p38	50,53	MRF4	19,23	p38	MRF4	1432	4618	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Phosphorylation of MRF4 transactivation domain by p38 mediates repression of specific myogenic genes .
11359653	0	p38	98,101	Monocyte_chemoattractant_protein-1	0,34	p38	Monocyte chemoattractant protein-1	81649(Tax:10116)	24770(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY production|dep|role production|amod|END_ENTITY	Monocyte_chemoattractant_protein-1 production by intestinal epithelial cells in vitro : a role for p38 in epithelial chemokine expression .
20396861	0	p38	43,46	NADPH_oxidase_4	24,39	p38	NADPH oxidase 4	1432	50507	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Sustained expression of NADPH_oxidase_4 by p38 MAPK-Akt signaling potentiates radiation-induced differentiation of lung fibroblasts .
18413810	0	p38	50,53	NAG-1	28,33	p38	NAG-1	1432	9518	Gene	Gene	mechanism|amod|START_ENTITY expression|nmod|mechanism expression|compound|END_ENTITY	Vitamin_E_succinate induces NAG-1 expression in a p38 kinase-dependent mechanism .
11087273	0	p38	61,64	NF-kappaB	85,94	p38	NF-kappaB	1432	4790	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	HIV gp120 enhances NO production by cardiac myocytes through p38 MAP kinase-mediated NF-kappaB activation .
11997522	0	p38	29,32	NFATc4	19,25	p38	NFATc4	26416(Tax:10090)	73181(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases .
16352664	0	p38	31,34	NP60	16,20	p38	NP60	1432	84656	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Nuclear protein NP60 regulates p38 MAPK activity .
16107717	0	p38	15,18	NRAGE	0,5	p38	NRAGE	1432	9500	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	NRAGE mediates p38 activation and neural progenitor apoptosis via the bone morphogenetic protein signaling cascade .
18056716	0	p38	90,93	Osterix	14,21	p38	Osterix	26416(Tax:10090)	170574(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38 .
23018344	0	p38	14,17	P-glycoprotein	86,100	p38	P-glycoprotein	1432	5243	Gene	Gene	MAPK|amod|START_ENTITY Inhibition|nmod|MAPK diminishes|nsubj|Inhibition diminishes|dobj|resistance resistance|acl|associated associated|nmod|END_ENTITY	Inhibition of p38 MAPK diminishes doxorubicin-induced drug resistance associated with P-glycoprotein in human leukemia K562 cells .
15582350	0	p38	71,74	P19	87,90	p38	P19	26416(Tax:10090)	83430(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|cells cells|compound|END_ENTITY	Nitrofen induces a redox-dependent apoptosis associated with increased p38 activity in P19 teratocarcinoma cells .
21388279	0	p38	32,35	P2Y6_receptor	15,28	p38	P2Y6 receptor	1432	5031	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Involvement of P2Y6_receptor in p38 MAPK-mediated COX-2 expression in response to UVB irradiation of human keratinocytes .
11741533	0	p38	51,54	PPARgamma	80,89	p38	PPARgamma	1432	5468	Gene	Gene	MAP|amod|START_ENTITY expenditure|nmod|MAP stimulation|nmod|expenditure kinase|nsubj|stimulation kinase|dobj|activation activation|nmod|END_ENTITY	Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1 .
18312546	0	p38	51,54	PPARgamma	15,24	p38	PPARgamma	26416(Tax:10090)	19016(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY pioglitazone|nmod|kinase pioglitazone|nsubj|Effects Effects|nmod|activator activator|compound|END_ENTITY	Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic_lateral_sclerosis .
19478555	0	p38	50,53	PPARgamma	110,119	p38	PPARgamma	1432	5468	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma .
11278444	0	p38	57,60	Pyk2	24,28	p38	Pyk2	1432	2185	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Protein-tyrosine kinase Pyk2 mediates endothelin-induced p38 MAPK activation in glomerular mesangial cells .
18954908	0	p38	119,122	Pyk2	106,110	p38	Pyk2	1432	2185	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase , Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway .
23935096	0	p38	87,90	RANTES	62,68	p38	RANTES	1432	6352	Gene	Gene	kinase|amod|START_ENTITY induction|nmod|kinase END_ENTITY|acl|induction	Sphingosine_kinase_1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kB activation .
17578844	0	p38	26,29	RIP2	0,4	p38	RIP2	1432	8767	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	RIP2 mediates LPS-induced p38 and IkappaBalpha signaling including IL-12 p40 expression in human monocyte-derived dendritic cells .
17996195	0	p38	61,64	RhoA	52,56	p38	RhoA	1432	387	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	IL-1beta promotes neurite_outgrowth by deactivating RhoA via p38 MAPK pathway .
20564243	0	p38	94,97	Runx2	112,117	p38	Runx2	1432	860	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation .
21806985	0	p38	83,86	Runx2	124,129	p38	Runx2	1432	860	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Ugonin_K promotes osteoblastic differentiation and mineralization by activation of p38 MAPK - and ERK-mediated expression of Runx2 and osterix .
14514016	0	p38	51,54	SHP2	25,29	p38	SHP2	26416(Tax:10090)	19247(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase_1 and 3 to foster neuronal survival .
10445852	0	p38	32,35	STAT3	94,99	p38	STAT3	1432	6774	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|IL-6 IL-6|acl|induced induced|dobj|activation activation|nmod|END_ENTITY	Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3 .
23236157	0	p38	82,85	Shp2	33,37	p38	Shp2	26416(Tax:10090)	19247(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY inhibition|nmod|kinase promotes|nmod|inhibition promotes|nsubj|END_ENTITY	Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase .
23269672	0	p38	69,72	Shp2	130,134	p38	Shp2	26416(Tax:10090)	19247(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY action|nmod|kinase degradation|nmod|action Modulation|nmod|degradation phosphatase|nsubj|Modulation phosphatase|dobj|END_ENTITY	Modulation of fatty_acid synthase degradation by concerted action of p38 MAP kinase , E3 ligase COP1 , and SH2-tyrosine phosphatase Shp2 .
19129540	0	p38	74,77	Socs-3	112,118	p38	Socs-3	1432	9021	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3 .
21898067	0	p38	80,83	Sox9	71,75	p38	Sox9	1432	6662	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Gluococorticoid could influence extracellular matrix synthesis through Sox9 via p38 MAPK pathway .
11278848	0	p38	4,7	Sp1	107,110	p38	Sp1	1432	6667	Gene	Gene	kinase|amod|START_ENTITY regulates|nsubj|kinase regulates|dobj|promoter promoter|nmod|activation activation|nmod|factor factor|amod|END_ENTITY	The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages .
16797880	0	p38	8,11	Sp1	36,39	p38	Sp1	81649(Tax:10116)	24790(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of p38 in stress activation of Sp1 .
21115498	0	p38	91,94	Sp1	126,129	p38	Sp1	81649(Tax:10116)	24790(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Heme_oxygenase-1 / carbon_monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1 .
24821721	0	p38	190,193	Sp1	149,152	p38	Sp1	1432	6667	Gene	Gene	pathway|amod|START_ENTITY specificity_protein_1|dep|pathway specificity_protein_1|appos|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
26466383	0	p38	63,66	Src	0,3	p38	Src	81649(Tax:10116)	83805(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38 , ERK/AP -1 Signaling and COX-2 Expression in YPEN-1 Cells .
10523640	0	p38	34,37	Stat3	79,84	p38	Stat3	1432	6774	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Requirement for Ras/Rac1-mediated p38 and c-Jun_N-terminal_kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein .
12215219	0	p38	20,23	Syk	0,3	p38	Syk	1432	6850	Gene	Gene	activation|amod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Syk is required for p38 activation and G2/M arrest in B cells exposed to oxidative stress .
19393267	0	p38	76,79	TAK1	42,46	p38	TAK1	1432	6885	Gene	Gene	phosphorylation|amod|START_ENTITY activation|nmod|phosphorylation activation|compound|END_ENTITY	Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding_protein_1 .
19393267	0	p38	76,79	TAK1-binding_protein_1	99,121	p38	TAK1-binding protein 1	1432	10454	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Cross interference with TNF-alpha-induced TAK1 activation via EGFR-mediated p38 phosphorylation of TAK1-binding_protein_1 .
22965824	0	p38	96,99	TGF-b	80,85	p38	TGF-b	1432	7040	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Microarray analysis of Dupuytren 's _ disease cells : the profibrogenic role of the TGF-b inducible p38 MAPK pathway .
11046029	0	p38	104,107	TGF-beta_1	83,93	p38	TGF-beta 1	1432	7040	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Potent induction of alpha -LRB- 1,3 -RRB- - fucosyltransferase VII in activated CD4 + T cells by TGF-beta_1 through a p38 mitogen-activated protein kinase-dependent pathway .
24821721	0	p38	190,193	TLR4	184,188	p38	TLR4	1432	7099	Gene	Gene	pathway|amod|START_ENTITY specificity_protein_1|dep|pathway specificity_protein_1|appos|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
10210635	0	p38	0,3	TNF-alpha	30,39	p38	TNF-alpha	1432	7124	Gene	Gene	inhibition|amod|START_ENTITY decreases|nsubj|inhibition decreases|dobj|production production|amod|END_ENTITY	p38 MAPK inhibition decreases TNF-alpha production and enhances postischemic human myocardial function .
10521481	0	p38	73,76	TNF-alpha	120,129	p38	TNF-alpha	1432	7124	Gene	Gene	protein|amod|START_ENTITY protein|dep|expression expression|amod|END_ENTITY	Engagement of tumor necrosis factor -LRB- TNF -RRB- receptor 1 leads to ATF-2 - and p38 mitogen-activated protein kinase-dependent TNF-alpha gene expression .
10620700	0	p38	12,15	TNF-alpha	86,95	p38	TNF-alpha	1432	7124	Gene	Gene	protein|amod|START_ENTITY role|nmod|protein kinase|nsubj|role kinase|nmod|production production|nmod|fibroblasts fibroblasts|amod|END_ENTITY	The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha - or IL-1beta-stimulated rheumatoid synovial fibroblasts .
10836611	0	p38	84,87	TNF-alpha	0,9	p38	TNF-alpha	1432	7124	Gene	Gene	pathway|amod|START_ENTITY induce|nmod|pathway induce|nsubj|END_ENTITY	TNF-alpha and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway .
10880231	0	p38	0,3	TNF-alpha	25,34	p38	TNF-alpha	1432	7124	Gene	Gene	kinase|amod|START_ENTITY regulates|nsubj|kinase regulates|dobj|production production|amod|END_ENTITY	p38 map kinase regulates TNF-alpha production in human astrocytes and microglia by multiple mechanisms .
11715476	0	p38	27,30	TNF-alpha	54,63	p38	TNF-alpha	1432	7124	Gene	Gene	MAPK|amod|START_ENTITY activation|nmod|MAPK role|nmod|activation -LSB-|dobj|role induced|csubj|-LSB- induced|nmod|LPS LPS|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The role of activation of p38 MAPK induced by LPS in TNF-alpha gene expression -RSB- .
11994432	0	p38	112,115	TNF-alpha	55,64	p38	TNF-alpha	1432	7124	Gene	Gene	protein|amod|START_ENTITY inhibition|nmod|protein involve|dobj|inhibition mechanism|acl:relcl|involve mechanism|nmod|suppression suppression|nmod|production production|amod|END_ENTITY	Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa_B in primary human macrophages .
11994493	0	p38	0,3	TNF-alpha	64,73	p38	TNF-alpha	5594	7124	Gene	Gene	kinase|nummod|START_ENTITY activated|nsubjpass|kinase activated|nmod|END_ENTITY	p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory_bowel_disease .
12096921	0	p38	15,18	TNF-alpha	79,88	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY pathways|nsubj|Involvement pathways|nmod|production production|nmod|END_ENTITY	Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells .
12142907	0	p38	0,3	TNF-alpha	33,42	p38	TNF-alpha	1432	7124	Gene	Gene	Signal|compound|START_ENTITY Necessary|nsubj|Signal Necessary|nmod|Expression Expression|compound|END_ENTITY	p38 MAPK Signal is Necessary for TNF-alpha Gene Expression in RAW Cells .
12297009	0	p38	8,11	TNF-alpha	69,78	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY MAPK|nsubj|Role MAPK|nmod|regulation regulation|nmod|apoptosis apoptosis|acl|signaling signaling|dep|induced induced|nmod|END_ENTITY	Role of p38 MAPK in the regulation of apoptosis signaling induced by TNF-alpha in differentiated PC12 cells .
12297293	0	p38	0,3	TNF-alpha	73,82	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	MAPK|compound|START_ENTITY mediates|nsubj|MAPK mediates|nmod|END_ENTITY	p38 MAPK mediates the regulation of alpha1 -LRB- I -RRB- procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells -LRB- 1 -RRB- .
14644621	0	p38	50,53	TNF-alpha	106,115	p38	TNF-alpha	26416(Tax:10090)	21926(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY roles|nmod|protein kinase|nsubj|roles kinase|nmod|upregulation upregulation|nmod|expression expression|amod|END_ENTITY	Transcriptional and posttranscriptional roles for p38 mitogen-activated protein kinase in upregulation of TNF-alpha expression by deoxynivalenol -LRB- vomitoxin -RRB- .
14656985	0	p38	100,103	TNF-alpha	30,39	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY cells|nmod|activation migration|nmod|cells attract|dobj|migration attract|nsubj|Cardiomyocytes Cardiomyocytes|acl|overexpressing overexpressing|dobj|END_ENTITY	Cardiomyocytes overexpressing TNF-alpha attract migration of embryonic stem cells via activation of p38 and c-Jun_amino-terminal_kinase .
15365619	0	p38	116,119	TNF-alpha	93,102	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Rosiglitazone ameliorates insulin resistance in brown_adipocytes of Wistar_rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases .
15557189	0	p38	46,49	TNF-alpha	22,31	p38	TNF-alpha	1432	7124	Gene	Gene	MAPK|amod|START_ENTITY regulation|nmod|MAPK regulation|amod|END_ENTITY	A novel mechanism for TNF-alpha regulation by p38 MAPK : involvement of NF-kappa_B with implications for therapy in rheumatoid_arthritis .
15603917	0	p38	66,69	TNF-alpha	19,28	p38	TNF-alpha	1432	7124	Gene	Gene	MAPK|amod|START_ENTITY expression|nmod|MAPK expression|nsubj|END_ENTITY	Xenobiotic-induced TNF-alpha expression and apoptosis through the p38 MAPK signaling pathway .
15979653	0	p38	41,44	TNF-alpha	16,25	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells .
16813528	0	p38	19,22	TNF-alpha	0,9	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats .
16819191	0	p38	151,154	TNF-alpha	112,121	p38	TNF-alpha	5594	7124	Gene	Gene	suppression|nmod|START_ENTITY decreases|dobj|suppression decreases|xcomp|binding binding|nmod|HT29 HT29|acl|stimulated stimulated|nmod|END_ENTITY	Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta : suppression of p38 , JNK and NF-kappaB_p65 as potential targets .
16935932	0	p38	82,85	TNF-alpha	14,23	p38	TNF-alpha	1432	7124	Gene	Gene	activation|amod|START_ENTITY suppression|nmod|activation mediated|nmod|suppression mediated|nsubjpass|destabilization destabilization|amod|END_ENTITY	IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression .
16949835	0	p38	9,12	TNF-alpha	55,64	p38	TNF-alpha	1432	7124	Gene	Gene	Roles|nmod|START_ENTITY kinases|nsubj|Roles kinases|nmod|expression expression|nmod|cells cells|amod|END_ENTITY	Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha - and dexamethasone-stimulated human periodontal ligament cells .
17906102	0	p38	0,3	TNF-alpha	46,55	p38	TNF-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|interplay interplay|nmod|END_ENTITY	p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac_myocyte_apoptosis .
19797215	0	p38	81,84	TNF-alpha	62,71	p38	TNF-alpha	534492(Tax:9913)	280943(Tax:9913)	Gene	Gene	kinase|amod|START_ENTITY role|nmod|kinase dysfunction|dep|role dysfunction|nmod|endothelium endothelium|nmod|response response|nmod|END_ENTITY	Barrier dysfunction of the corneal endothelium in response to TNF-alpha : role of p38 MAP kinase .
9120304	0	p38	47,50	TNF-alpha	171,180	p38	TNF-alpha	26416(Tax:10090)	21926(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|parataxis|role role|nmod|p42MAPK p42MAPK|nmod|synthesis synthesis|amod|END_ENTITY	Fc gamma receptor cross-linking activates p42 , p38 , and JNK/SAPK mitogen-activated protein kinases in murine macrophages : role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis .
9469462	0	p38	0,3	TNF-alpha	103,112	p38	TNF-alpha	1432	7124	Gene	Gene	activation|amod|START_ENTITY required|nsubjpass|activation required|nmod|function function|acl|triggered triggered|nmod|stimulation stimulation|compound|END_ENTITY	p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation .
25700345	0	p38	46,49	TRAF6	0,5	p38	TRAF6	1432	7189	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	TRAF6 is required for the GM-CSF-induced JNK , p38 and Akt activation .
25572524	0	p38	72,75	TRAIL	101,106	p38	TRAIL	5594	8743	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous_carcinoma FaDu cells .
10329406	0	p38	33,36	Thioredoxin	0,11	p38	Thioredoxin	26416(Tax:10090)	22166(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor_necrosis_factor-alpha .
11867688	0	p38	79,82	Toll-like_receptor_2	0,20	p38	Toll-like receptor 2	1432	7097	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Toll-like_receptor_2 -LRB- TLR2 -RRB- mediates activation of stress-activated MAP kinase p38 .
18795068	0	p38	33,36	UCP2	14,18	p38	UCP2	1432	7351	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Modulation of UCP2 expression by p38 -- a link to cardioprotection .
22552405	0	p38	80,83	Urotensin_II	0,12	p38	Urotensin II	81649(Tax:10116)	29180(Tax:10116)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Urotensin_II promotes the proliferation of endothelial progenitor cells through p38 and p44/42 MAPK activation .
23053343	0	p38	113,116	Urotensin_II	0,12	p38	Urotensin II	81649(Tax:10116)	29180(Tax:10116)	Gene	Gene	MAPK|amod|START_ENTITY rat|nmod|MAPK promotes|advcl|rat promotes|nsubj|END_ENTITY	Urotensin_II promotes the production of LTC4 in rat aortic adventitial fibroblasts through NF-kB-5-LO pathway by p38 MAPK and ERK activations .
19609071	0	p38	84,87	VCAM-1	72,78	p38	VCAM-1	26416(Tax:10090)	22329(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Cadmium stimulates the expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- via p38 mitogen-activated protein kinase -LRB- MAPK -RRB- and JNK activation in cerebrovascular endothelial cells .
22522454	0	p38	73,76	VEGF	54,58	p38	VEGF	1432	7422	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	TGF-b1 induces endothelial cell apoptosis by shifting VEGF activation of p38 -LRB- MAPK -RRB- from the prosurvival p38b to proapoptotic p38a .
23517865	0	p38	45,48	VR-1	60,64	p38	VR-1	81649(Tax:10116)	83810(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Intervention of electroacupuncture on spinal p38 MAPK/ATF -2 / VR-1 pathway in treating inflammatory_pain induced by CFA in rats .
27026405	0	p38	23,26	X-ray_repair_cross-complement_group_1	42,79	p38	X-ray repair cross-complement group 1	1432	7515	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
27026405	0	p38	23,26	XRCC1	81,86	p38	XRCC1	1432	7515	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Curcumin downregulates p38 MAPK-dependent X-ray_repair_cross-complement_group_1 -LRB- XRCC1 -RRB- expression to enhance cisplatin-induced cytotoxicity in human lung_cancer cells .
17689131	0	p38	37,40	activator_protein_1	51,70	p38	activator protein 1	1432	3725	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The mitogen-activated protein kinase p38 regulates activator_protein_1 by direct phosphorylation of c-Jun .
19151763	0	p38	19,22	androgen_receptor	65,82	p38	androgen receptor	1432	367	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Hypoxia-associated p38 mitogen-activated protein kinase-mediated androgen_receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate_cancer .
10837470	0	p38	0,3	bid	46,49	p38	bid	1432	637	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	p38 mitogen-activated protein kinase mediates bid cleavage , mitochondrial_dysfunction , and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen_peroxide .
15956019	0	p38	75,78	bone_morphogenetic_protein-2	46,74	p38	bone morphogenetic protein-2	5594	650	Gene	Gene	differentiation|parataxis|START_ENTITY differentiation|dep|END_ENTITY	Osthole-mediated cell differentiation through bone_morphogenetic_protein-2 / p38 and extracellular_signal-regulated_kinase_1 / 2 pathway in human osteoblast cells .
17113042	0	p38	88,91	bone_morphogenetic_protein-2	59,87	p38	bone morphogenetic protein-2	1432	650	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Myricetin induces human osteoblast differentiation through bone_morphogenetic_protein-2 / p38 mitogen-activated protein kinase pathway .
17980360	0	p38	102,105	bone_morphogenetic_protein-2	15,43	p38	bone morphogenetic protein-2	81649(Tax:10116)	29373(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY Enhancement|nmod|pathway Enhancement|nmod|expression expression|amod|END_ENTITY	Enhancement of bone_morphogenetic_protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts .
22799302	0	p38	130,133	bone_morphogenetic_protein-2	42,70	p38	bone morphogenetic protein-2	1432	650	Gene	Gene	MAPK|amod|START_ENTITY cells|nmod|MAPK cells|amod|insulin-like_growth_factor-1 insulin-like_growth_factor-1|nmod|expression expression|amod|END_ENTITY	Effect of insulin-like_growth_factor-1 on bone_morphogenetic_protein-2 expression in hepatic_carcinoma SMMC7721 cells through the p38 MAPK signaling pathway .
24257756	0	p38	53,56	c-Myb	44,49	p38	c-Myb	1432	4602	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Stress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2 / 3 .
14607516	0	p38	18,21	cAMP_response_element-binding_protein	40,77	p38	cAMP response element-binding protein	1432	1385	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Downregulation of p38 kinase pathway by cAMP_response_element-binding_protein protects HL-60 cells from iron chelator-induced apoptosis .
12746452	0	p38	17,20	cFLIP-L	0,7	p38	cFLIP-L	1432	8837	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	cFLIP-L inhibits p38 MAPK activation : an additional anti-apoptotic mechanism in bile_acid-mediated apoptosis .
17438464	0	p38	65,68	calreticulin	83,95	p38	calreticulin	81649(Tax:10116)	64202(Tax:10116)	Gene	Gene	upregulation|amod|START_ENTITY upregulation|compound|END_ENTITY	Hypoxic preconditioning induces delayed cardioprotection through p38 MAPK-mediated calreticulin upregulation .
12370831	0	p38	12,15	cyclooxygenase-2	31,47	p38	cyclooxygenase-2	1432	5743	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line , HaCaT .
15753376	0	p38	0,3	cyclooxygenase-2	14,30	p38	cyclooxygenase-2	1432	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue .
16256948	0	p38	123,126	cyclooxygenase-2	25,41	p38	cyclooxygenase-2	1432	5743	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases .
18664364	0	p38	63,66	discoidin_domain_receptor-2	16,43	p38	discoidin domain receptor-2	1432	4921	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Hypoxia induces discoidin_domain_receptor-2 expression via the p38 pathway in vascular smooth muscle cells to increase their migration .
15797859	0	p38	0,3	epidermal_growth_factor_receptor	43,75	p38	epidermal growth factor receptor	1432	1956	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|END_ENTITY	p38 kinase-mediated transactivation of the epidermal_growth_factor_receptor is required for dedifferentiation of renal epithelial cells after oxidant injury .
11941315	0	p38	0,3	glucocorticoid_receptor	45,68	p38	glucocorticoid receptor	1432	2908	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	p38 Mitogen-activated protein kinase-induced glucocorticoid_receptor phosphorylation reduces its activity : role in steroid-insensitive asthma .
16210322	0	p38	89,92	glucose-6-phosphate_dehydrogenase	51,84	p38	glucose-6-phosphate dehydrogenase	1432	2539	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Arachidonic_acid inhibits the insulin induction of glucose-6-phosphate_dehydrogenase via p38 MAP kinase .
20470771	0	p38	105,108	glycogen_synthase_kinase-3beta	143,173	p38	glycogen synthase kinase-3beta	534492(Tax:9913)	790875(Tax:9913)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Nav1.7-Ca2 + influx-induced increased phosphorylations of extracellular signal-regulated kinase -LRB- ERK -RRB- and p38 attenuate tau phosphorylation via glycogen_synthase_kinase-3beta : priming of Nav1 .7 gating by ERK and p38 .
24117426	0	p38	98,101	haeme_oxygenase-1	72,89	p38	haeme oxygenase-1	1432	3162	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Andrographolide exerts_anti-hepatitis_C virus activity by up-regulating haeme_oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells .
16849502	0	p38	94,97	heme_oxygenase-1	28,44	p38	heme oxygenase-1	1432	3162	Gene	Gene	isoform|amod|START_ENTITY degradation|nmod|isoform involves|dobj|degradation involves|nsubj|effect effect|nmod|END_ENTITY	The antiapoptotic effect of heme_oxygenase-1 in endothelial cells involves the degradation of p38 alpha MAPK isoform .
18846504	0	p38	4,7	heme_oxygenase-1	82,98	p38	heme oxygenase-1	81649(Tax:10116)	24451(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY involved|nsubjpass|kinase involved|nmod|regulation regulation|nmod|cells cells|amod|END_ENTITY	The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme_oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells .
20822529	0	p38	121,124	heme_oxygenase-1	87,103	p38	heme oxygenase-1	1432	3162	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Hemin inhibits NO production by IL-1b-stimulated human astrocytes through induction of heme_oxygenase-1 and reduction of p38 MAPK activation .
20954800	0	p38	19,22	heme_oxygenase-1	64,80	p38	heme oxygenase-1	26416(Tax:10090)	15368(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	Involvement of the p38 pathway in the differential induction of heme_oxygenase-1 by statins in Neuro-2A cells exposed to lipopolysaccharide .
22137262	0	p38	89,92	heme_oxygenase-1	47,63	p38	heme oxygenase-1	1432	3162	Gene	Gene	MAPK|amod|START_ENTITY cells|nmod|MAPK END_ENTITY|nmod|cells	Epigallocatechin gallate induces expression of heme_oxygenase-1 in endothelial cells via p38 MAPK and Nrf-2 that suppresses proinflammatory actions of TNF-a .
22369644	0	p38	48,51	heme_oxygenase-1	23,39	p38	heme oxygenase-1	26416(Tax:10090)	15368(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Ethyl_pyruvate induces heme_oxygenase-1 through p38 mitogen-activated protein kinase activation by depletion of glutathione in RAW 264.7 cells and improves survival in septic animals .
22875631	0	p38	101,104	heme_oxygenase-1	4,20	p38	heme oxygenase-1	1432	3162	Gene	Gene	pathway|amod|START_ENTITY autophagy|nmod|pathway induces|xcomp|autophagy induces|nsubj|ZnPPIX ZnPPIX|amod|END_ENTITY	The heme_oxygenase-1 inhibitor ZnPPIX induces non-canonical , Beclin_1-independent , autophagy through p38 MAPK pathway .
21609580	0	p38	41,44	human_leukocyte_antigen-G	12,37	p38	human leukocyte antigen-G	1432	3135	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	-LSB- Effects of human_leukocyte_antigen-G on p38 mitogen-activated protein kinase signaling pathway in HTR-8 / SVneo cell line -RSB- .
10447723	0	p38	15,18	iNOS	82,86	p38	iNOS	1432	4843	Gene	Gene	protein|amod|START_ENTITY Involvement|nmod|protein kinase|nsubj|Involvement kinase|nmod|END_ENTITY	Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages .
10644515	0	p38	76,79	iNOS	67,71	p38	iNOS	81649(Tax:10116)	24599(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation .
15086905	0	p38	99,102	iNOS	76,80	p38	iNOS	1432	4843	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|appos|END_ENTITY	Advanced_glycosylation end products induce inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via a p38 MAPK-dependent pathway .
15217752	0	p38	0,3	iNOS	55,59	p38	iNOS	81649(Tax:10116)	24599(Tax:10116)	Gene	Gene	MAPK|compound|START_ENTITY inhibits|nsubj|MAPK inhibits|dobj|END_ENTITY	p38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells .
18289732	0	p38	14,17	iNOS	130,134	p38	iNOS	81649(Tax:10116)	24599(Tax:10116)	Gene	Gene	MAPK|amod|START_ENTITY Activation|nmod|MAPK rat|nsubj|Activation rat|dobj|astrocytes astrocytes|nmod|activation activation|nmod|END_ENTITY	Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase .
19055030	0	p38	12,15	iNOS	45,49	p38	iNOS	1432	4843	Gene	Gene	Role|nmod|START_ENTITY MAPK|nsubj|Role MAPK|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Role of the p38 MAPK pathway in induction of iNOS expression in human leukocytes .
19576750	0	p38	72,75	iNOS	15,19	p38	iNOS	1432	4843	Gene	Gene	MAPK|amod|START_ENTITY regulation|nmod|MAPK mediated|nmod|regulation mediated|nsubjpass|Suppression Suppression|nmod|expression expression|amod|END_ENTITY	Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK , JAK/STAT , AP-1 and IRF-1 , and depends on up-regulation of scavenger_receptor_B1 expression in TNF-alpha - and IFN-gamma-stimulated C6 glioma cells .
23856614	0	p38	115,118	iNOS	90,94	p38	iNOS	5594	4843	Gene	Gene	phosphorylation|compound|START_ENTITY showed|dobj|phosphorylation showed|nmod|inhibition inhibition|nmod|END_ENTITY	Vorinostat , a HDAC inhibitor , showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression , p38 and ERK phosphorylation and blocking NF-kB nuclear translocation .
15086905	0	p38	99,102	inducible_nitric_oxide_synthase	43,74	p38	inducible nitric oxide synthase	1432	4843	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Advanced_glycosylation end products induce inducible_nitric_oxide_synthase -LRB- iNOS -RRB- expression via a p38 MAPK-dependent pathway .
15228086	0	p38	24,27	insulin	42,49	p38	insulin	1432	3630	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones .
15228086	0	p38	24,27	insulin	53,60	p38	insulin	1432	3630	Gene	Gene	activation|amod|START_ENTITY Restoration|nmod|activation Restoration|nmod|cells cells|compound|END_ENTITY	Restoration of impaired p38 activation by insulin in insulin resistant skeletal muscle cells treated with thiazolidinediones .
8626622	0	p38	14,17	insulin	54,61	p38	insulin	417553(Tax:9031)	396145(Tax:9031)	Gene	Gene	mitogen-activated_protein|amod|START_ENTITY Inhibition|nmod|mitogen-activated_protein kinase|nsubj|Inhibition kinase|nmod|END_ENTITY	Inhibition of p38 mitogen-activated_protein kinase by insulin in cultured fetal neurons .
22392142	0	p38	96,99	interleukin_8	73,86	p38	interleukin 8	1432	3576	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|amod|END_ENTITY	NADPH oxidase-derived superoxide destabilizes lipopolysaccharide-induced interleukin_8 mRNA via p38 , extracellular signal-regulated kinase mitogen-activated protein kinase , and the destabilizing factor tristetraprolin .
25739356	0	p38	63,66	lysosome-associated_membrane_protein-1	84,122	p38	lysosome-associated membrane protein-1	1432	3916	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Extracellular galectin-3 induces MMP9 expression by activating p38 MAPK pathway via lysosome-associated_membrane_protein-1 -LRB- LAMP1 -RRB- .
11121811	0	p38	131,134	monocyte-chemoattractant_protein-1	90,124	p38	monocyte-chemoattractant protein-1	1432	6347	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant_protein-1 via a p38 mitogen-activated protein kinase mediated pathway .
26044505	0	p38	73,76	osteoprotegerin	43,58	p38	osteoprotegerin	26416(Tax:10090)	18383(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY synthesis|nmod|kinase synthesis|compound|END_ENTITY	Resveratrol amplifies BMP __ -4 - stimulated osteoprotegerin synthesis via p38 MAP kinase in osteoblasts .
18729196	0	p38	162,165	p-glycoprotein	129,143	p38	p-glycoprotein	81649(Tax:10116)	287115(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Acidosis induces multi-drug resistance in rat prostate_cancer cells -LRB- AT1 -RRB- in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38 .
21445777	0	p38	115,118	p-glycoprotein	49,63	p38	p-glycoprotein	81649(Tax:10116)	287115(Tax:10116)	Gene	Gene	vivo|nmod|START_ENTITY tumors|nmod|vivo increases|nmod|tumors increases|dobj|activity activity|amod|END_ENTITY	Hypoxia-induced extracellular acidosis increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway .
11306695	0	p38	15,18	p21	51,54	p38	p21	1432	644914	Gene	Gene	activity|amod|START_ENTITY receptors|nsubj|activity receptors|amod|critical critical|nmod|induction induction|amod|END_ENTITY	High-intensity p38 kinase activity is critical for p21 -LRB- cip1 -RRB- induction and the antiproliferative function of G -LRB- i -RRB- protein-coupled receptors .
16344056	0	p38	111,114	p21	82,85	p38	p21	26416(Tax:10090)	12575(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY induction|nmod|kinase END_ENTITY|acl|induction	Clostridium_difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21 -LRB- WAF1/CIP1 -RRB- induction via p38 mitogen-activated protein kinase .
21816217	0	p38	65,68	p21	56,59	p38	p21	1432	644914	Gene	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKa dependent manner .
22227330	0	p38	119,122	p21	137,140	p38	p21	1432	1026	Gene	Gene	stabilization|amod|START_ENTITY stabilization|amod|END_ENTITY	Neferine , an alkaloid ingredient in lotus seed embryo , inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization .
22490020	0	p38	154,157	p21	114,117	p38	p21	1432	1026	Gene	Gene	MAPK|amod|START_ENTITY cells|nmod|MAPK cells|amod|dependent dependent|nmod|induction induction|amod|END_ENTITY	TGF-b-activated kinase 1 promotes cell cycle arrest and cell survival of X-ray irradiated HeLa cells dependent on p21 induction but independent of NF-kB , p38 MAPK and ERK phosphorylations .
23751077	0	p38	63,66	p21	81,84	p38	p21	1432	644914	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Gadd45g regulates dental epithelial cell proliferation through p38 MAPK-mediated p21 expression .
23759594	0	p38	11,14	p21	48,51	p38	p21	1432	1026	Gene	Gene	START_ENTITY|nmod|elongation elongation|nmod|END_ENTITY	A role for p38 in transcriptional elongation of p21 -LRB- CIP1 -RRB- in response to Aurora_B inhibition .
15767673	0	p38	71,74	p300	41,45	p38	p300	1432	2033	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells .
10212189	0	p38	0,3	p53	50,53	p38	p53	5594	7157	Gene	Gene	kinase|amod|START_ENTITY mediates|nsubj|kinase mediates|dobj|phosphorylation phosphorylation|nmod|protein protein|compound|END_ENTITY	p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389 .
10581258	0	p38	32,35	p53	25,28	p38	p53	1432	7157	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation .
10811125	0	p38	15,18	p53	97,100	p38	p53	1432	7157	Gene	Gene	protein|amod|START_ENTITY role|nmod|protein kinase|nsubj|role kinase|nmod|activation activation|nmod|END_ENTITY	A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents .
12071847	0	p38	27,30	p53	154,157	p38	p53	1432	7157	Gene	Gene	kinase|amod|START_ENTITY activation|nmod|kinase enhances|nsubj|activation enhances|advcl|stabilizing stabilizing|dobj|END_ENTITY	UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53 .
12091386	0	p38	0,3	p53	94,97	p38	p53	1432	7157	Gene	Gene	kinase|amod|START_ENTITY regulates|nsubj|kinase regulates|advcl|accumulating accumulating|dobj|END_ENTITY	p38 kinase regulates nitric_oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa_B-dependent transcription and stabilization by serine 15 phosphorylation .
12807754	0	p38	9,12	p53	92,95	p38	p53	1432	7157	Gene	Gene	Roles|nmod|START_ENTITY Roles|nmod|induction induction|compound|END_ENTITY	Roles of p38 - and c-jun_NH2-terminal_kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis .
15642743	0	p38	41,44	p53	18,21	p38	p53	1432	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope .
15963507	0	p38	33,36	p53	4,7	p38	p53	1432	7157	Gene	Gene	MAPK|amod|START_ENTITY synergized|nmod|MAPK synergized|nsubjpass|END_ENTITY	The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11 ' - dideoxyverticillin-induced G2/M arrest .
16244358	0	p38	173,176	p53	118,121	p38	p53	26416(Tax:10090)	22060(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY role|nmod|kinase phosphorylation|dep|role phosphorylation|nmod|END_ENTITY	Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation : role of p38 MAP kinase .
16297369	0	p38	0,3	p53	84,87	p38	p53	1432	7157	Gene	Gene	kinase|nummod|START_ENTITY regulates|nsubj|kinase regulates|dobj|benzo benzo|dep|apoptosis apoptosis|nmod|regulation regulation|nmod|activation activation|compound|END_ENTITY	p38 MAP kinase regulates benzo -LRB- a -RRB- pyrene-induced apoptosis through the regulation of p53 activation .
19020042	0	p38	24,27	p53	139,142	p38	p53	26416(Tax:10090)	22060(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY activation|nmod|kinase leads|nsubj|activation leads|nmod|translocation translocation|nmod|END_ENTITY	Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine-treated mice .
19583730	0	p38	102,105	p53	56,59	p38	p53	1432	7157	Gene	Gene	activation|amod|START_ENTITY enhances|nmod|activation enhances|dobj|cytotoxicity cytotoxicity|nmod|cells cells|nummod|END_ENTITY	Dicoumarol enhances doxorubicin-induced cytotoxicity in p53 wild-type urothelial_cancer cells through p38 activation .
20590525	0	p38	0,3	p53	10,13	p38	p53	1432	7157	Gene	Gene	inhibition|amod|START_ENTITY inhibition|amod|/ /|ccomp|mediates mediates|nsubj|axis axis|compound|END_ENTITY	p38 -LRB- MAPK -RRB- / p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition : implication for neurodegeneration .
21059157	0	p38	62,65	p53	41,44	p38	p53	1432	7157	Gene	Gene	decrease|amod|START_ENTITY accumulation|nmod|decrease accumulation|compound|END_ENTITY	SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease , eventually leading to apoptosis .
21519792	0	p38	18,21	p53	52,55	p38	p53	5594	7157	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon_cancer-derived metastatic cells .
21983885	0	p38	74,77	p53	24,27	p38	p53	1432	7157	Gene	Gene	kinases|dobj|START_ENTITY kinases|nsubj|Role Role|nmod|END_ENTITY	Role and interaction of p53 , BAX and the stress-activated protein kinases p38 and JNK in benzo -LRB- a -RRB- pyrene-diolepoxide induced apoptosis in human colon_carcinoma cells .
22342995	0	p38	0,3	p53	95,98	p38	p53	5594	7157	Gene	Gene	dictate|nsubj|START_ENTITY dictate|xcomp|SH-SY5Y SH-SY5Y|nsubj|response response|nmod|stimuli stimuli|nmod|END_ENTITY	p38 -LRB- MAPK -RRB- and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y .
23638878	0	p38	8,11	p53	65,68	p38	p53	5594	7157	Gene	Gene	Role|nmod|START_ENTITY MAPK|nsubj|Role MAPK|xcomp|signaling signaling|dobj|END_ENTITY	Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549_lung_cancer cells .
23859040	0	p38	77,80	p53	43,46	p38	p53	1432	7157	Gene	Gene	death|nmod|START_ENTITY death|nmod|activation activation|compound|END_ENTITY	Epicatechin_gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon_cancer SW480 cells .
24297112	0	p38	105,108	p53	65,68	p38	p53	1432	7157	Gene	Gene	MAPK|amod|START_ENTITY apoptosis|nmod|MAPK apoptosis|nmod|cells cells|nmod|END_ENTITY	Oridonin induces apoptosis in SW1990 pancreatic_cancer cells via p53 - and caspase-dependent induction of p38 MAPK .
24599959	0	p38	0,3	p53	16,19	p38	p53	1432	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p38 regulates p53 to control p21Cip1 expression in human epidermal keratinocytes .
24269898	0	p38	0,3	p62	33,36	p38	p62	1432	8878	Gene	Gene	START_ENTITY|dep|induction induction|nmod|END_ENTITY	p38 -LRB- MAPK -RRB- - regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling .
2504884	0	p38	87,90	p65	63,66	p38	p65	1432	64689	Gene	Gene	distribution|appos|START_ENTITY distribution|nmod|END_ENTITY	Subcellular distribution of 65,000 calmodulin-binding_protein -LRB- p65 -RRB- and synaptophysin -LRB- p38 -RRB- in adrenal medulla .
11840343	0	p38	39,42	p73	14,17	p38	p73	1432	7161	Gene	Gene	pathway|amod|START_ENTITY Regulation|nmod|pathway Regulation|nmod|END_ENTITY	Regulation of p73 by c-Abl through the p38 MAP kinase pathway .
11098049	0	p38	33,36	parathyroid_hormone	91,110	p38	parathyroid hormone	1432	5741	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid_hormone .
16338464	0	p38	11,14	peroxisome_proliferator_activated_receptor-gamma	25,73	p38	peroxisome proliferator activated receptor-gamma	1432	5468	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The kinase p38 regulates peroxisome_proliferator_activated_receptor-gamma in human trophoblasts .
12186863	0	p38	37,40	phosphatase-2A	19,33	p38	phosphatase-2A	1432	5524	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH -LRB- 2 -RRB- - terminal kinase pathway in human neutrophils .
19540572	0	p38	70,73	plasminogen_activator_inhibitor-1	32,65	p38	plasminogen activator inhibitor-1	1432	5054	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Nox4 mediates the expression of plasminogen_activator_inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells .
18799583	0	p38	88,91	programmed_death_1	48,66	p38	programmed death 1	1432	5133	Gene	Gene	mechanism|amod|START_ENTITY induces|nmod|mechanism induces|dobj|expression expression|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef induces programmed_death_1 expression through a p38 mitogen-activated protein kinase-dependent mechanism .
24821721	0	p38	190,193	specificity_protein_1	126,147	p38	specificity protein 1	1432	6667	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|dep|pathway	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
18829074	0	p38	63,66	synaptophysin	40,53	p38	synaptophysin	1432	6855	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The immunohistochemical localization of synaptophysin protein -LRB- p38 -RRB- in the gastro-entero-pancreatic _ -LRB- GEP -RRB- _ system of reptiles .
1908264	0	p38	58,61	synaptophysin	35,48	p38	synaptophysin	81649(Tax:10116)	24804(Tax:10116)	Gene	Gene	protein|nummod|START_ENTITY END_ENTITY|appos|protein	Immunocytochemical localization of synaptophysin -LRB- protein p38 -RRB- and synapsin_I in nerve terminals of rat neurohypophysis .
2115313	0	p38	51,54	synaptophysin	36,49	p38	synaptophysin	1432	6855	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of synaptophysin -LRB- p38 -RRB- in the pineal gland of the Mongolian gerbil -LRB- Meriones unguiculatus -RRB- .
3139837	0	p38	42,45	synaptophysin	19,32	p38	synaptophysin	81649(Tax:10116)	24804(Tax:10116)	Gene	Gene	protein|nummod|START_ENTITY END_ENTITY|appos|protein	In adrenal medulla synaptophysin -LRB- protein p38 -RRB- is present in chromaffin granules and in a special vesicle population .
8102940	0	p38	56,59	synaptophysin	32,45	p38	synaptophysin	81649(Tax:10116)	24804(Tax:10116)	Gene	Gene	protein|nummod|START_ENTITY Changes|dep|protein Changes|nmod|immunoreactivity immunoreactivity|nmod|END_ENTITY	Changes of immunoreactivity for synaptophysin -LRB- ` protein p38 ' -RRB- following a transient cerebral_ischemia in the rat striatum .
8213090	0	p38	86,89	synaptophysin	63,76	p38	synaptophysin	81649(Tax:10116)	24804(Tax:10116)	Gene	Gene	protein|nummod|START_ENTITY END_ENTITY|appos|protein	Distinct neuronal subset reveals perikaryal immunostaining for synaptophysin -LRB- protein p38 -RRB- in the striatum of rats .
25979559	0	p38	0,3	toll-like_receptor_4	39,59	p38	toll-like receptor 4	1432	7099	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	p38 and interleukin-1_beta pathway via toll-like_receptor_4 contributed to the skin and muscle incision and retraction-induced allodynia .
19124561	0	p38	124,127	tumor_necrosis_factor-alpha	88,115	p38	tumor necrosis factor-alpha	1432	7124	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor_necrosis_factor-alpha via the p38 mitogen-activated protein kinase pathway .
10889466	0	p38	97,100	vascular_endothelial_growth_factor	21,55	p38	vascular endothelial growth factor	26416(Tax:10090)	22339(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY involvement|nmod|kinase induces|parataxis|involvement induces|dobj|synthesis synthesis|compound|END_ENTITY	Endothelin-1 induces vascular_endothelial_growth_factor synthesis in osteoblasts : involvement of p38 mitogen-activated protein kinase .
11245489	0	p38	108,111	vascular_endothelial_growth_factor	17,51	p38	vascular endothelial growth factor	26416(Tax:10090)	22339(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Up-regulation of vascular_endothelial_growth_factor in breast_cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration .
11524243	0	p38	0,3	vascular_endothelial_growth_factor	110,144	p38	vascular endothelial growth factor	26416(Tax:10090)	22339(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY involved|nsubjpass|protein involved|nmod|synthesis synthesis|compound|END_ENTITY	p38 mitogen-activated protein -LRB- MAP -RRB- kinase but not p44/p42 MAP kinase is involved in prostaglandin_E1-induced vascular_endothelial_growth_factor synthesis in osteoblasts .
12482858	0	p38	23,26	vascular_endothelial_growth_factor	89,123	p38	vascular endothelial growth factor	1432	7422	Gene	Gene	role|nmod|START_ENTITY Evidence|nmod|role kinase|nsubj|Evidence kinase|nmod|induction induction|nmod|expression expression|compound|END_ENTITY	Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular_endothelial_growth_factor expression by sodium_arsenite .
15719130	0	p38	0,3	vascular_endothelial_growth_factor	62,96	p38	vascular endothelial growth factor	5594	7422	Gene	Gene	kinase|nummod|START_ENTITY mediates|nsubj|kinase mediates|dobj|release release|compound|END_ENTITY	p38 Mitogen-activated protein kinase mediates hypoxia-induced vascular_endothelial_growth_factor release in human endothelial cells .
16452201	0	p38	83,86	vascular_endothelial_growth_factor	19,53	p38	vascular endothelial growth factor	1432	7422	Gene	Gene	levels|amod|START_ENTITY correlation|nmod|levels expression|dep|correlation expression|compound|END_ENTITY	Heparanase induces vascular_endothelial_growth_factor expression : correlation with p38 phosphorylation levels and Src activation .
16595708	0	p38	90,93	vascular_endothelial_growth_factor	43,77	p38	vascular endothelial growth factor	26416(Tax:10090)	22339(Tax:10090)	Gene	Gene	mitogen|amod|START_ENTITY stimulates|nmod|mitogen stimulates|dobj|synthesis synthesis|nmod|END_ENTITY	Angiotensin_II stimulates the synthesis of vascular_endothelial_growth_factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytes .
23177780	0	p38	79,82	vascular_endothelial_growth_factor	32,66	p38	vascular endothelial growth factor	1432	7422	Gene	Gene	pathway|amod|START_ENTITY promotes|nmod|pathway promotes|dobj|expression expression|nmod|END_ENTITY	IL-6 promotes the expression of vascular_endothelial_growth_factor through the p38 signalling pathway in hypertrophied adenoids in children .
23401656	0	p38	126,129	vascular_endothelial_growth_factor	27,61	p38	vascular endothelial growth factor	1432	7422	Gene	Gene	cultures|dep|START_ENTITY Regulation|dep|cultures Regulation|nmod|secretion secretion|compound|END_ENTITY	Regulation of constitutive vascular_endothelial_growth_factor secretion in retinal_pigment_epithelium / choroid organ cultures : p38 , nuclear factor kB , and the vascular_endothelial_growth_factor receptor-2 / phosphatidylinositol 3 kinase pathway .
25132397	0	p38	187,190	vascular_endothelial_growth_factor	104,138	p38	vascular endothelial growth factor	26416(Tax:10090)	22339(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY has|nsubj|kinase upregulation|acl:relcl|has upregulation|nmod|process process|compound|END_ENTITY	Interleukin-4_and_granulocyte-macrophage_colony-stimulating_factor mediates the upregulation of soluble vascular_endothelial_growth_factor receptor-1 in RAW264 .7 cells-a process in which p38 mitogen-activated protein kinase signaling has an important role .
9393975	0	p38	0,3	vascular_endothelial_growth_factor	29,63	p38	vascular endothelial growth factor	1432	7422	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	p38 MAP kinase activation by vascular_endothelial_growth_factor mediates actin reorganization and cell migration in human endothelial cells .
18669934	0	p38	40,43	xanthine_oxidoreductase	78,101	p38	xanthine oxidoreductase	1432	7498	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine_oxidoreductase in ventilator-induced lung_injury .
22039048	0	p38MAPK	147,154	Adiponectin	0,11	p38MAPK	Adiponectin	1432	9370	Gene	Gene	activation|nmod|START_ENTITY stimulates|nmod|activation stimulates|nsubj|END_ENTITY	Adiponectin stimulates proliferation of adult hippocampal neural stem/progenitor cells through activation of p38_mitogen-activated_protein_kinase -LRB- p38MAPK -RRB- / glycogen_synthase_kinase_3b -LRB- GSK-3b -RRB- / b-catenin signaling cascade .
18402807	0	p38MAPK	91,98	C-reactive_protein	0,18	p38MAPK	C-reactive protein	26416(Tax:10090)	12944(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	C-reactive_protein induces high-mobility_group_box-1 protein release through activation of p38MAPK in macrophage RAW264 .7 cells .
15107845	0	p38MAPK	32,39	CD40	11,15	p38MAPK	CD40	26416(Tax:10090)	21939(Tax:10090)	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Reciprocal CD40 signals through p38MAPK and ERK-1 / 2 induce counteracting immune responses .
17481611	0	p38MAPK	74,81	COX-2	49,54	p38MAPK	COX-2	26416(Tax:10090)	17709(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|compound|END_ENTITY	The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell .
20616349	0	p38MAPK	60,67	HIF-1alpha	49,59	p38MAPK	HIF-1alpha	26416(Tax:10090)	15251(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Morphine suppresses tumor angiogenesis through a HIF-1alpha / p38MAPK pathway .
11755113	0	p38MAPK	96,103	p38_mitogen-activated_protein_kinase	58,94	p38MAPK	p38 mitogen-activated protein kinase	81649(Tax:10116)	81649(Tax:10116)	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Potentiation of cyclic_AMP and cyclic_GMP accumulation by p38_mitogen-activated_protein_kinase -LRB- p38MAPK -RRB- inhibitors in rat pinealocytes .
20978232	0	p38_MAPK	38,46	APPL1	0,5	p38 MAPK	APPL1	26416(Tax:10090)	72993(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	APPL1 mediates adiponectin-stimulated p38_MAPK activation by scaffolding the TAK1-MKK3-p38_MAPK pathway .
16714293	0	p38_MAPK	25,33	Bcl-2	0,5	p38 MAPK	Bcl-2	26416(Tax:10090)	12043(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	Bcl-2 Phosphorylation by p38_MAPK : identification of target sites and biologic consequences .
17533378	0	p38_MAPK	95,103	ERK1/2	75,81	p38 MAPK	ERK1/2	26416(Tax:10090)	26417;26413	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Indirubin-3 ' - monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38_MAPK .
15195698	0	p38_MAPK	0,8	IL-1beta	19,27	p38 MAPK	IL-1beta	26416(Tax:10090)	16176(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p38_MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts .
15195698	0	p38_MAPK	0,8	IL-6	36,40	p38 MAPK	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|IL-1beta IL-1beta|acl|induced induced|dobj|expression expression|compound|END_ENTITY	p38_MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts .
15316034	0	p38_MAPK	128,136	IL-6	35,39	p38 MAPK	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY potentiates|parataxis|involvement potentiates|dobj|production production|compound|END_ENTITY	Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation : involvement of p38_MAPK .
16229818	0	p38_MAPK	37,45	IL-6	17,21	p38 MAPK	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	AICAR stimulates IL-6 production via p38_MAPK in cardiac fibroblasts in adult mice : a possible role for AMPK .
17114490	0	p38_MAPK	62,70	IL-6	31,35	p38 MAPK	IL-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY expression|nmod|effects expression|compound|END_ENTITY	Annexin_1 negatively regulates IL-6 expression via effects on p38_MAPK and MAPK_phosphatase-1 .
11447117	0	p38_MAPK	23,31	Interleukin-10	0,14	p38 MAPK	Interleukin-10	26416(Tax:10090)	16153(Tax:10090)	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	Interleukin-10 targets p38_MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology .
25007875	0	p38_MAPK	104,112	M-CSF	83,88	p38 MAPK	M-CSF	26416(Tax:10090)	12977(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Rho-kinase regulation of TNF-a-induced nuclear translocation of NF-kB RelA/p65 and M-CSF expression via p38_MAPK in mesangial cells .
21873449	0	p38_MAPK	96,104	MK2	105,108	p38 MAPK	MK2	26416(Tax:10090)	17164(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Regulation of monocyte subset proinflammatory responses within the lung microvasculature by the p38_MAPK / MK2 pathway .
20683677	0	p38_MAPK	58,66	MMP-2	17,22	p38 MAPK	MMP-2	26416(Tax:10090)	17390(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|compound|END_ENTITY	Leptin regulates MMP-2 , TIMP-1 and collagen synthesis via p38_MAPK in HL-1 murine cardiomyocytes .
17219434	0	p38_MAPK	52,60	PP2Cdelta	0,9	p38 MAPK	PP2Cdelta	26416(Tax:10090)	53892(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	PP2Cdelta -LRB- Ppm1d , WIP1 -RRB- , an endogenous inhibitor of p38_MAPK , is regulated along with Trp53 and Cdkn2a following p38_MAPK inhibition during mouse preimplantation development .
26038599	0	p38_MAPK	70,78	RACK1	21,26	p38 MAPK	RACK1	26416(Tax:10090)	14694(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	The scaffold protein RACK1 mediates the RANKL-dependent activation of p38_MAPK in osteoclast precursors .
22330023	0	p38_MAPK	23,31	TLR2	0,4	p38 MAPK	TLR2	26416(Tax:10090)	24088(Tax:10090)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	TLR2 and TLR4 activate p38_MAPK and JNK during endurance exercise in skeletal muscle .
14553829	0	p38_MAPK	14,22	TNF-alpha	44,53	p38 MAPK	TNF-alpha	26416(Tax:10090)	21926(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY decreases|nsubj|Inhibition decreases|dobj|expression expression|amod|END_ENTITY	Inhibition of p38_MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia .
15746179	0	p38_MAPK	19,27	TNF-alpha	0,9	p38 MAPK	TNF-alpha	26416(Tax:10090)	21926(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|amod|END_ENTITY	TNF-alpha acts via p38_MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle .
17151142	0	p38_MAPK	69,77	TNF-alpha	0,9	p38 MAPK	TNF-alpha	26416(Tax:10090)	21926(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	TNF-alpha regulates myogenesis and muscle regeneration by activating p38_MAPK .
20499049	0	p38_MAPK	142,150	TNF-alpha	14,23	p38 MAPK	TNF-alpha	1432	7124	Gene	Gene	blocking|dobj|START_ENTITY attenuated|advcl|blocking attenuated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of TNF-alpha and IL-6 in HMC-1 cells treated with bisphenol_A is attenuated by plant-originating glycoprotein -LRB- 75 kDa -RRB- by blocking p38_MAPK .
17219434	0	p38_MAPK	113,121	Trp53	86,91	p38 MAPK	Trp53	26416(Tax:10090)	22059(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	PP2Cdelta -LRB- Ppm1d , WIP1 -RRB- , an endogenous inhibitor of p38_MAPK , is regulated along with Trp53 and Cdkn2a following p38_MAPK inhibition during mouse preimplantation development .
23026374	0	p38_MAPK	78,86	c-Jun_N-terminal_kinase	10,33	p38 MAPK	c-Jun N-terminal kinase	81649(Tax:10116)	116554(Tax:10116)	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of c-Jun_N-terminal_kinase -LRB- JNK -RRB- / p38_mitogen-activated_protein_kinase -LRB- p38_MAPK -RRB- in morphine-induced tau protein_hyperphosphorylation .
15333638	0	p38_MAPK	55,63	endothelial_nitric-oxide_synthase	14,47	p38 MAPK	endothelial nitric-oxide synthase	1432	4846	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of endothelial_nitric-oxide_synthase by the p38_MAPK in response to black tea polyphenols .
11877395	0	p38_MAPK	79,87	p53	67,70	p38 MAPK	p53	26416(Tax:10090)	22060(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Insulin-like_growth_factor_I induces MDM2-dependent degradation of p53 via the p38_MAPK pathway in response to DNA damage .
18642443	0	p38_MAPK	38,46	p53	26,29	p38 MAPK	p53	1432	7157	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|END_ENTITY	Chk1 inhibition activates p53 through p38_MAPK in tetraploid_cancer cells .
12506117	0	p38_MAPK	130,138	tumor_necrosis_factor-alpha	73,100	p38 MAPK	tumor necrosis factor-alpha	26416(Tax:10090)	21926(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Endothelial_nitric-oxide_synthase enhances lipopolysaccharide-stimulated tumor_necrosis_factor-alpha expression via cAMP-mediated p38_MAPK pathway in cardiomyocytes .
21091771	0	p38_MAPK	66,74	uPA	54,57	p38 MAPK	uPA	1432	5328	Gene	Gene	regulate|nmod|START_ENTITY regulate|dobj|expression expression|nmod|END_ENTITY	Integrin b3 and its ligand regulate the expression of uPA through p38_MAPK in breast_cancer .
10679516	0	p38_MAP_kinase	0,14	HSP27	54,59	p38 MAP kinase	HSP27	81649(Tax:10116)	24471(Tax:10116)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|induction induction|compound|END_ENTITY	p38_MAP_kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells .
10843887	0	p38_MAP_kinase	54,68	HSP27	69,74	p38 MAP kinase	HSP27	1432	3315	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Evidence for modulation of smooth muscle force by the p38_MAP_kinase / HSP27 pathway .
10095033	0	p38_MAP_kinase	24,38	HSP70	42,47	p38 MAP kinase	HSP70	81649(Tax:10116)	266759(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Possible involvement of p38_MAP_kinase in HSP70 expression induced by hypoxia in rat primary astrocytes .
11053030	0	p38_MAP_kinase	0,14	IL-1_beta	25,34	p38 MAP kinase	IL-1 beta	1432	3553	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|responses responses|compound|END_ENTITY	p38_MAP_kinase regulates IL-1_beta responses in cultured airway smooth muscle cells .
10604552	0	p38_MAP_kinase	0,14	RANTES	25,31	p38 MAP kinase	RANTES	1432	6352	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|compound|END_ENTITY	p38_MAP_kinase regulates RANTES production by TNF-alpha-stimulated human pulmonary vascular endothelial cells .
7499191	0	p38_MAP_kinase	31,45	Thrombin	0,8	p38 MAP kinase	Thrombin	1432	2147	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Thrombin induces activation of p38_MAP_kinase in human platelets .
11500937	0	p38_MAP_kinase	15,29	VEGF	53,57	p38 MAP kinase	VEGF	81649(Tax:10116)	83785(Tax:10116)	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Involvement of p38_MAP_kinase in TGF-beta-stimulated VEGF synthesis in aortic smooth muscle cells .
10908576	0	p38_MAP_kinase	0,14	bax	24,27	p38 MAP kinase	bax	1432	581	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	p38_MAP_kinase mediates bax translocation in nitric_oxide-induced apoptosis in neurons .
17483741	0	p38_MAP_kinase	15,29	cPLA2	104,109	p38 MAP kinase	cPLA2	81649(Tax:10116)	24653(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p38_MAP_kinase in burn-induced degradation of membrane phospholipids and upregulation of cPLA2 in cardiac myocytes .
23539296	0	p38_Mitogen-activated_protein_kinase	0,36	CAR	64,67	p38 Mitogen-activated protein kinase	CAR	1432	9970	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p38_Mitogen-activated_protein_kinase regulates nuclear receptor CAR that activates the CYP2B6 gene .
12058028	0	p38_alpha	37,46	Cip1	70,74	p38 alpha	Cip1	1432	1026	Gene	Gene	stabilize|nsubj|START_ENTITY stabilize|dobj|END_ENTITY	The stress-activated protein kinases p38_alpha and JNK1 stabilize p21 -LRB- Cip1 -RRB- by phosphorylation .
25367151	0	p38_and_nuclear_factor-kappaB	232,261	extracellular_signal-regulated_kinase	193,230	p38 and nuclear factor-kappaB	extracellular signal-regulated kinase	1432	5594	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Down-regulating peroxisome_proliferator-activated_receptor-gamma_coactivator-1beta alleviates the proinflammatory effect of rheumatoid_arthritis fibroblast-like synoviocytes through inhibiting extracellular_signal-regulated_kinase , p38_and_nuclear_factor-kappaB activation .
19676105	0	p38_mitogen-activated_protein_kinase	86,122	Bcl-2	156,161	p38 mitogen-activated protein kinase	Bcl-2	1432	596	Gene	Gene	activation|amod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Curcumin-induced apoptosis in ovarian_carcinoma cells is p53-independent and involves p38_mitogen-activated_protein_kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling .
24936062	0	p38_mitogen-activated_protein_kinase	52,88	F-box_only_protein_31	0,21	p38 mitogen-activated protein kinase	F-box only protein 31	1432	79791	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	F-box_only_protein_31 -LRB- FBXO31 -RRB- negatively regulates p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated_protein_kinase_kinase_6 -LRB- MKK6 -RRB- .
12376363	0	p38_mitogen-activated_protein_kinase	34,70	HO-1	21,25	p38 mitogen-activated protein kinase	HO-1	1432	3162	Gene	Gene	cells|amod|START_ENTITY END_ENTITY|nmod|cells	TGF-beta1 stimulates HO-1 via the p38_mitogen-activated_protein_kinase in A549 pulmonary epithelial cells .
9727040	0	p38_mitogen-activated_protein_kinase	15,51	Hsp_27	52,58	p38 mitogen-activated protein kinase	Hsp 27	81649(Tax:10116)	24471(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|amod|END_ENTITY	A role for the p38_mitogen-activated_protein_kinase / Hsp_27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini .
12667212	0	p38_mitogen-activated_protein_kinase	4,40	IL-8	114,118	p38 mitogen-activated protein kinase	IL-8	1432	3576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|effect effect|nmod|promoter promoter|compound|END_ENTITY	The p38_mitogen-activated_protein_kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells .
12667212	0	p38_mitogen-activated_protein_kinase	4,40	IL-8	77,81	p38 mitogen-activated protein kinase	IL-8	1432	3576	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The p38_mitogen-activated_protein_kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells .
15225374	0	p38_mitogen-activated_protein_kinase	139,175	IL-8	60,64	p38 mitogen-activated protein kinase	IL-8	1432	3576	Gene	Gene	inhibitor|amod|START_ENTITY RWJ_67657|appos|inhibitor inhibition|nmod|RWJ_67657 inhibition|nmod|expression expression|amod|END_ENTITY	Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ_67657 , a p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- inhibitor .
16192891	0	p38_mitogen-activated_protein_kinase	51,87	IL-8	28,32	p38 mitogen-activated protein kinase	IL-8	1432	3576	Gene	Gene	species|amod|START_ENTITY enhances|nmod|species enhances|dobj|secretion secretion|compound|END_ENTITY	Interleukin-1alpha enhances IL-8 secretion through p38_mitogen-activated_protein_kinase and reactive oxygen species signaling in human pancreatic_cancer cells .
18277946	0	p38_mitogen-activated_protein_kinase	4,40	IL-8	99,103	p38 mitogen-activated protein kinase	IL-8	1432	3576	Gene	Gene	pathway|amod|START_ENTITY plays|nsubj|pathway plays|dobj|role role|nmod|production production|compound|END_ENTITY	The p38_mitogen-activated_protein_kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion .
11238627	0	p38_mitogen-activated_protein_kinase	20,56	TNF-alpha	145,154	p38 mitogen-activated protein kinase	TNF-alpha	1432	7124	Gene	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|END_ENTITY	A critical role for p38_mitogen-activated_protein_kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide , TNF-alpha , and contact sensitizers .
10523409	0	p38_mitogen-activated_protein_kinase	118,154	cyclooxygenase-2	13,29	p38 mitogen-activated protein kinase	cyclooxygenase-2	1432	5743	Gene	Gene	involvement|nmod|START_ENTITY Induction|dep|involvement Induction|nmod|expression expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta : involvement of p38_mitogen-activated_protein_kinase .
11466386	0	p38_mitogen-activated_protein_kinase	110,146	cyclooxygenase-2	19,35	p38 mitogen-activated protein kinase	cyclooxygenase-2	81649(Tax:10116)	29527(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY associated|nmod|activation associated|nsubjpass|levels levels|nmod|END_ENTITY	Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38_mitogen-activated_protein_kinase .
11795877	0	p38_mitogen-activated_protein_kinase	8,44	cyclooxygenase-2	80,96	p38 mitogen-activated protein kinase	cyclooxygenase-2	81649(Tax:10116)	29527(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of p38_mitogen-activated_protein_kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression .
17208222	0	p38_mitogen-activated_protein_kinase	61,97	cyclooxygenase-2	25,41	p38 mitogen-activated protein kinase	cyclooxygenase-2	1432	5743	Gene	Gene	shuttling|amod|START_ENTITY inhibiting|dobj|shuttling destabilizes|advcl|inhibiting destabilizes|dobj|mRNA mRNA|amod|END_ENTITY	Thalidomide destabilizes cyclooxygenase-2 mRNA by inhibiting p38_mitogen-activated_protein_kinase and cytoplasmic shuttling of HuR .
17482227	0	p38_mitogen-activated_protein_kinase	78,114	cyclooxygenase-2	42,58	p38 mitogen-activated protein kinase	cyclooxygenase-2	1432	5743	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	2,2 ' ,4,4 ' - Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38_mitogen-activated_protein_kinase and NF-kappaB .
9867839	0	p38_mitogen-activated_protein_kinase	0,36	cyclooxygenase-2	47,63	p38 mitogen-activated protein kinase	cyclooxygenase-2	1432	5743	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	p38_mitogen-activated_protein_kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes .
15051668	0	p38_mitogen-activated_protein_kinase	0,36	endothelin-1	89,101	p38 mitogen-activated protein kinase	endothelin-1	81649(Tax:10116)	24323(Tax:10116)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	p38_mitogen-activated_protein_kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats .
8798479	0	p38_mitogen-activated_protein_kinase	24,60	glia_maturation_factor	88,110	p38 mitogen-activated protein kinase	glia maturation factor	1432	2764	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	In vitro enhancement of p38_mitogen-activated_protein_kinase activity by phosphorylated glia_maturation_factor .
10067858	0	p38_mitogen-activated_protein_kinase	18,54	gonadotropin-releasing_hormone	66,96	p38 mitogen-activated protein kinase	gonadotropin-releasing hormone	1432	2796	Gene	Gene	pathway|amod|START_ENTITY Activation|nmod|pathway Activation|nmod|END_ENTITY	Activation of the p38_mitogen-activated_protein_kinase pathway by gonadotropin-releasing_hormone .
17603092	0	p38_mitogen-activated_protein_kinase	44,80	hepatocyte_nuclear_factor-4alpha	89,121	p38 mitogen-activated protein kinase	hepatocyte nuclear factor-4alpha	1432	3172	Gene	Gene	START_ENTITY|dep|phosphorylation phosphorylation|amod|END_ENTITY	Activation of bile_acid biosynthesis by the p38_mitogen-activated_protein_kinase -LRB- MAPK -RRB- : hepatocyte_nuclear_factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol_7alpha-hydroxylase expression .
24032631	0	p38_mitogen-activated_protein_kinase	45,81	interferon-y	24,36	p38 mitogen-activated protein kinase	interferon-y	1432	3458	Gene	Gene	signalling|amod|START_ENTITY END_ENTITY|nmod|signalling	Autophagy activation by interferon-y via the p38_mitogen-activated_protein_kinase signalling pathway is involved in macrophage bactericidal activity .
19913910	0	p38_mitogen-activated_protein_kinase	12,48	leukemia_inhibitory_factor	66,92	p38 mitogen-activated protein kinase	leukemia inhibitory factor	1432	3976	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The role of p38_mitogen-activated_protein_kinase in serum-induced leukemia_inhibitory_factor secretion by bone marrow stromal cells from pediatric myelodysplastic_syndromes .
16834927	0	p38_mitogen-activated_protein_kinase	93,129	monocyte_chemoattractant_protein-1	43,77	p38 mitogen-activated protein kinase	monocyte chemoattractant protein-1	81649(Tax:10116)	24770(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Advanced oxidation protein products induce monocyte_chemoattractant_protein-1 expression via p38_mitogen-activated_protein_kinase activation in rat vascular smooth muscle cells .
11755113	0	p38_mitogen-activated_protein_kinase	58,94	p38MAPK	96,103	p38 mitogen-activated protein kinase	p38MAPK	81649(Tax:10116)	81649(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Potentiation of cyclic_AMP and cyclic_GMP accumulation by p38_mitogen-activated_protein_kinase -LRB- p38MAPK -RRB- inhibitors in rat pinealocytes .
15634764	0	p38_mitogen-activated_protein_kinase	11,47	serotonin_transporter	73,94	p38 mitogen-activated protein kinase	serotonin transporter	1432	6532	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	A role for p38_mitogen-activated_protein_kinase in the regulation of the serotonin_transporter : evidence for distinct cellular mechanisms involved in transporter surface expression .
10783388	0	p38_mitogen-activated_protein_kinase	14,50	tumor_necrosis_factor-alpha	67,94	p38 mitogen-activated protein kinase	tumor necrosis factor-alpha	1432	7124	Gene	Gene	Activation|nmod|START_ENTITY required|nsubjpass|Activation required|nmod|END_ENTITY	Activation of p38_mitogen-activated_protein_kinase is required for tumor_necrosis_factor-alpha - supported proliferation of leukemia and lymphoma cell lines .
11373433	0	p38_mitogen-activated_protein_kinase	147,183	tumor_necrosis_factor-alpha	31,58	p38 mitogen-activated protein kinase	tumor necrosis factor-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY involvement|nmod|pathway Effects|dep|involvement Effects|nmod|inhibitor inhibitor|nmod|END_ENTITY	Effects of a dual inhibitor of tumor_necrosis_factor-alpha and interleukin-1 on lipopolysaccharide-induced lung_injury in rats : involvement of the p38_mitogen-activated_protein_kinase pathway .
16480618	0	p38_mitogen-activated_protein_kinase	24,60	tumor_necrosis_factor-alpha	82,109	p38 mitogen-activated protein kinase	tumor necrosis factor-alpha	81649(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The modulating role of p38_mitogen-activated_protein_kinase in the expression of tumor_necrosis_factor-alpha in hepatic cells and its role in hepatic_injury in severely burned rats -RSB- .
26959880	0	p38_mitogen-activated_protein_kinase	59,95	twist1	96,102	p38 mitogen-activated protein kinase	twist1	1432	7291	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Prp19 facilitates invasion_of_hepatocellular_carcinoma via p38_mitogen-activated_protein_kinase / twist1 pathway .
9020057	0	p38_mitogen_activated_protein_kinase	0,36	VCAM-1	59,65	p38 mitogen activated protein kinase	VCAM-1	1432	7412	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	p38_mitogen_activated_protein_kinase regulates endothelial VCAM-1 expression at the post-transcriptional level .
25073020	0	p38a	44,48	IGFBP-3	14,21	p38a	IGFBP-3	1432	3486	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	TNFa inhibits IGFBP-3 through activation of p38a and casein kinase 2 in human retinal endothelial cells .
17615176	0	p38alpha	67,75	Bax	105,108	p38alpha	Bax	1432	581	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Epidermal_growth_factor_receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells .
18437159	0	p38alpha	34,42	Bcl2	0,4	p38alpha	Bcl2	26416(Tax:10090)	12043(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Bcl2 , a transcriptional target of p38alpha , is critical for neuronal commitment of mouse embryonic stem cells .
20547488	0	p38alpha	23,31	MAP_kinase_phosphatase-1	66,90	p38alpha	MAP kinase phosphatase-1	1432	1843	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP_kinase_phosphatase-1 determines cellular sensitivity to UV radiation .
17369826	0	p38alpha	45,53	Rho	0,3	p38alpha	Rho	81649(Tax:10116)	24717(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death .
16207331	0	p38alpha	71,79	Tumour_necrosis_factor	0,22	p38alpha	Tumour necrosis factor	1432	7124	Gene	Gene	kinases|dobj|START_ENTITY activates|ccomp|kinases activates|nsubj|END_ENTITY	Tumour_necrosis_factor activates the mitogen-activated protein kinases p38alpha and ERK in the synovial membrane in vivo .
19586613	0	p38alpha	0,8	caspase-9	50,59	p38alpha	caspase-9	1432	842	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	p38alpha - and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress .
10943842	0	p38alpha	16,24	erythropoietin	28,42	p38alpha	erythropoietin	1432	2056	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Requirement for p38alpha in erythropoietin expression : a role for stress kinases in erythropoiesis .
18042545	0	p38alpha	0,8	interleukin-6	20,33	p38alpha	interleukin-6	26416(Tax:10090)	16193(Tax:10090)	Gene	Gene	stabilizes|nsubj|START_ENTITY stabilizes|dobj|mRNA mRNA|amod|END_ENTITY	p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements .
11454875	0	p38alpha	54,62	involucrin	21,31	p38alpha	involucrin	1432	3713	Gene	Gene	mechanism|amod|START_ENTITY expression|nmod|mechanism expression|compound|END_ENTITY	MEK6 regulates human involucrin gene expression via a p38alpha - and p38delta - dependent mechanism .
12374793	0	p38alpha	82,90	mitogen-activated_protein_kinase_kinase_3	15,56	p38alpha	mitogen-activated protein kinase kinase 3	26416(Tax:10090)	26397(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Requirement of mitogen-activated_protein_kinase_kinase_3 -LRB- MKK3 -RRB- for activation of p38alpha and p38delta MAPK isoforms by TGF-beta_1 in murine mesangial cells .
11000134	0	p38alpha	103,111	protein_tyrosine_phosphatase	54,82	p38alpha	protein tyrosine phosphatase	1432	26191	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Adenosine induces endothelial apoptosis by activating protein_tyrosine_phosphatase : a possible role of p38alpha .
23639288	0	p38b	57,61	CREB	81,85	p38b	CREB	5600	1385	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	p27 suppresses cyclooxygenase-2 expression by inhibiting p38b and p38 - mediated CREB phosphorylation upon arsenite exposure .
23807508	0	p38b	0,4	Pokemon	35,42	p38b	Pokemon	5600	51341	Gene	Gene	START_ENTITY|appos|Target Target|nmod|END_ENTITY	p38b , A Novel Regulatory Target of Pokemon in Hepatic Cells .
20724307	0	p38b	131,135	p53	113,116	p38b	p53	689314(Tax:10116)	301300(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|acl|inhibition	Oestrogen prevents cardiomyocyte apoptosis by suppressing p38a-mediated activation of p53 and by down-regulating p53 inhibition on p38b .
11211234	0	p38beta2	59,67	p75	52,55	p38beta2	p75	5600	3560	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities .
20605917	0	p38gamma	0,8	hDlg	81,85	p38gamma	hDlg	6300	1739	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock .
9379049	0	p38mapk	14,21	TNF-alpha	41,50	p38mapk	TNF-alpha	26416(Tax:10090)	21926(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of p38mapk , MKK3 , and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages .
3135941	0	p39	24,27	AP-1	71,75	p39	AP-1	3725	3725	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	fos-associated cellular p39 is related to nuclear transcription factor AP-1 .
10599848	0	p39	51,54	CDK5	36,40	p39	CDK5	8941	140908(Tax:10116)	Gene	Gene	activator|dobj|START_ENTITY activator|nsubj|localization localization|nmod|END_ENTITY	Immunohistochemical localization of CDK5 activator p39 in the rat brain .
17394551	0	p39	6,9	Cdk5	0,4	p39	Cdk5	8941	1020	Gene	Gene	complex|nsubj|START_ENTITY p35|parataxis|complex p35|nsubj|END_ENTITY	Cdk5 -- p39 is a labile complex with the similar substrate specificity to Cdk5 -- p35 .
23645679	0	p39	0,3	Cdk5	58,62	p39	Cdk5	12570(Tax:10090)	12568(Tax:10090)	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	p39 , the primary activator for cyclin-dependent_kinase_5 -LRB- Cdk5 -RRB- in oligodendroglia , is essential for oligodendroglia differentiation and myelin repair .
10683146	0	p39	0,3	cdk5	14,18	p39	cdk5	12570(Tax:10090)	12568(Tax:10090)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	p39 activates cdk5 in neurons , and is associated with the actin cytoskeleton .
10923673	0	p39	25,28	cdk5	54,58	p39	cdk5	8941	1020	Gene	Gene	localization|nmod|START_ENTITY localization|appos|activator activator|nmod|END_ENTITY	Synaptic localization of p39 , a neuronal activator of cdk5 .
12699769	0	p39	41,44	cyclin-dependent_kinase_5	4,29	p39	cyclin-dependent kinase 5	12570(Tax:10090)	12568(Tax:10090)	Gene	Gene	activator|appos|START_ENTITY activator|amod|END_ENTITY	The cyclin-dependent_kinase_5 activator , p39 , is expressed in stripes in the mouse cerebellum .
19437621	0	p39	90,93	cyclin-dependent_kinase_5_regulatory_subunit_2	42,88	p39	cyclin-dependent kinase 5 regulatory subunit 2	8941	8941	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Sp1 and Sp3 regulate transcription of the cyclin-dependent_kinase_5_regulatory_subunit_2 -LRB- p39 -RRB- promoter in neuronal cells .
12645940	0	p40	21,24	IL-4	0,4	p40	IL-4	3578	3565	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IL-4 regulates IL-12 p40 expression post-transcriptionally as well as via a promoter-based mechanism .
9317112	0	p40	60,63	IL-4	34,38	p40	IL-4	3578	3565	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|generation generation|nmod|presence presence|nmod|END_ENTITY	CTL generation in the presence of IL-4 is inhibited by free p40 : evidence for early and late IL-12 function .
11110796	0	p40	81,84	NF-kappaB	53,62	p40	NF-kappaB	16160(Tax:10090)	18033(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells .
11006016	0	p40	66,69	NF-kappa_B	0,10	p40	NF-kappa B	16160(Tax:10090)	18033(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	NF-kappa_B regulates the LPS-induced expression of interleukin 12 p40 in murine peritoneal macrophages : roles of PKC , PKA , ERK , p38_MAPK , and proteasome .
10647903	0	p40	29,32	eIF3	78,82	p40	eIF3	3578	8661	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The EIF3S3 gene encoding the p40 subunit of the translation initiation factor eIF3 has eight exons and maps to the Langer-Giedion_syndrome chromosome region on 8q24 , but is not the TRPS1 gene .
14976188	0	p40	44,47	erythroid_Kruppel-like_factor	65,94	p40	erythroid Kruppel-like factor	16160(Tax:10090)	16596(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY transcription|nsubj|Activation transcription|nmod|END_ENTITY	Activation and repression of interleukin-12 p40 transcription by erythroid_Kruppel-like_factor in macrophages .
10651849	0	p40	94,97	interleukin-12_p35	56,74	p40	interleukin-12 p35	3578	3592	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Rare polymorphisms in the promoter regions of the human interleukin-12_p35 and interleukin-12 p40 subunit genes .
14562279	0	p40	31,34	p63	12,15	p40	p63	8626	8626	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of p63 and deltaNp63 -LRB- p40 -RRB- protein expression and gene amplification in esophageal carcinogenesis .
22056955	0	p40	0,3	p63	28,31	p40	p63	8626	8626	Gene	Gene	superior|nsubj|START_ENTITY superior|nmod|END_ENTITY	p40 -LRB- / \ Np63 -RRB- is superior to p63 for the diagnosis of pulmonary_squamous_cell_carcinoma .
18413597	0	p400	23,27	Myc	63,66	p400	Myc	57634	4609	Gene	Gene	START_ENTITY|xcomp|induce induce|dobj|END_ENTITY	Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc .
7957080	0	p40MO15	0,7	p36	26,29	p40MO15	p36	399461(Tax:8355)	394356(Tax:8355)	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes .
11258927	0	p40phox	181,188	p47phox	149,156	p40phox	p47phox	4689	653361	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox .
26960148	0	p41	24,27	Cysteine_Protease	55,72	p41	Cysteine Protease	5594	1508	Gene	Gene	Activity|amod|START_ENTITY Activity|compound|END_ENTITY	Exogenous Thyropin from p41 Invariant Chain Diminishes Cysteine_Protease Activity and Affects IL-12 Secretion during Maturation of Human Dendritic Cells .
20489206	0	p42	152,155	AUF1	156,160	p42	AUF1	2038	3184	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	Leukotriene_B -LRB- 4 -RRB- BLT receptor signaling regulates the level and stability of cyclooxygenase-2 -LRB- COX-2 -RRB- mRNA through restricted activation of Ras/Raf/ERK / p42 AUF1 pathway .
20716519	0	p42	5,8	AUF1	0,4	p42	AUF1	2038	3184	Gene	Gene	isoform|amod|START_ENTITY isoform|nummod|END_ENTITY	AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay .
23831605	0	p42	12,15	C/EBPa	24,30	p42	C/EBPa	23552	1050	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	Lack of the p42 form of C/EBPa leads to spontaneous immortalization and lineage infidelity of committed myeloid progenitors .
11248233	0	p42	86,89	Protein_kinase_C_mu	0,19	p42	Protein kinase C mu	23552	5587	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Protein_kinase_C_mu selectively activates the mitogen-activated protein kinase -LRB- MAPK -RRB- p42 pathway .
9710599	0	p42	59,62	c-fms	140,145	p42	c-fms	23552	1436	Gene	Gene	kinases|dobj|START_ENTITY kinases|nmod|END_ENTITY	Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating_factor_1 / c-fms signaling .
8706669	1	p42	145,148	cPLA2	136,141	p42	cPLA2	23552	5321	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity .
22184527	0	p42	103,106	p30	114,117	p42	p30	2038	201161	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Differential effects of sumoylation on the activities of CCAAT_enhancer_binding_protein_alpha -LRB- C/EBPa -RRB- p42 versus p30 may contribute in part , to aberrant C/EBPa activity in acute_leukemias .
8380583	0	p42	86,89	phospholipase_A2	66,82	p42	phospholipase A2	8814	151056	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Phosphorylation and activation of a high molecular weight form of phospholipase_A2 by p42 microtubule-associated protein 2 kinase and protein_kinase_C .
9120304	0	p42MAPK	131,138	TNF-alpha	171,180	p42MAPK	TNF-alpha	26413(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|synthesis synthesis|amod|END_ENTITY	Fc gamma receptor cross-linking activates p42 , p38 , and JNK/SAPK mitogen-activated protein kinases in murine macrophages : role for p42MAPK in Fc gamma receptor-stimulated TNF-alpha synthesis .
15341746	0	p42_MAPK	39,47	Mos	0,3	p42 MAPK	Mos	398985(Tax:8355)	397924(Tax:8355)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Mos mediates the mitotic activation of p42_MAPK in Xenopus egg extracts .
11479298	0	p42_MAPK	52,60	progesterone_receptor	14,35	p42 MAPK	progesterone receptor	398985(Tax:8355)	373629(Tax:8355)	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|END_ENTITY	The classical progesterone_receptor associates with p42_MAPK and is involved in phosphatidylinositol_3-kinase signaling in Xenopus oocytes .
9530111	0	p42mapk	14,21	interleukin-1_alpha	67,86	p42mapk	interleukin-1 alpha	5594	3552	Gene	Gene	Activation|nmod|START_ENTITY endothelial|nsubj|Activation endothelial|nmod|END_ENTITY	Activation of p42mapk in human umbilical vein endothelial cells by interleukin-1_alpha and tumor_necrosis_factor-alpha .
17525271	0	p43	64,67	Aminoacyl-tRNA_synthetase-interacting_multifunctional_protein_1	0,63	p43	Aminoacyl-tRNA synthetase-interacting multifunctional protein 1	13722(Tax:10090)	13722(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY END_ENTITY|parataxis|controls	Aminoacyl-tRNA_synthetase-interacting_multifunctional_protein_1 / p43 controls endoplasmic reticulum retention of heat_shock protein gp96 : its pathological implications in lupus-like autoimmune_diseases .
15890366	0	p44	79,82	TFIIH	94,99	p44	TFIIH	10561	2966	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Dynamics and metal exchange properties of C4C4 RING domains from CNOT4 and the p44 subunit of TFIIH .
9880511	0	p44	53,56	TFIIH	68,73	p44	TFIIH	2966	2966	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The hematopoietic transcription factor SCL binds the p44 subunit of TFIIH .
9822659	0	p44	39,42	eIF3	99,103	p44	eIF3	10561	8661	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3 .
15132979	0	p44	138,141	macrophage_inflammatory_protein-2	16,49	p44	macrophage inflammatory protein-2	26417(Tax:10090)	20310(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|amod|END_ENTITY	Hypoxia induces macrophage_inflammatory_protein-2 -LRB- MIP-2 -RRB- gene expression in murine macrophages via NF-kappaB : the prominent role of p42 / p44 and PI3 kinase pathways .
8947493	0	p44ERK1	54,61	extracellular_signal-regulated_kinase_1	70,109	p44ERK1	extracellular signal-regulated kinase 1	50689(Tax:10116)	50689(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Kinetic and biochemical correlation between sustained p44ERK1 -LRB- 44 kDa extracellular_signal-regulated_kinase_1 -RRB- activation and lysophosphatidic_acid-stimulated DNA synthesis in Rat-1 cells .
9645686	0	p44MAPK	203,210	mitogen-activated_protein_kinase_kinase_1	125,166	p44MAPK	mitogen-activated protein kinase kinase 1	5595	5604	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Insulin induction of protein_kinase_C_alpha expression is independent of insulin_receptor Tyr1162/1163 residues and involves mitogen-activated_protein_kinase_kinase_1 and sustained activation of nuclear p44MAPK .
8380983	0	p44mapk	27,34	ERK1	36,40	p44mapk	ERK1	5595	5595	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Differential activation of p44mapk -LRB- ERK1 -RRB- by alpha-thrombin and thrombin-receptor peptide agonist .
7706248	0	p44mapk	46,53	Transforming_growth_factor_beta	0,31	p44mapk	Transforming growth factor beta	5595	7040	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Transforming_growth_factor_beta activation of p44mapk in proliferating cultures of epithelial cells .
2428624	0	p45	21,24	BLAST-2	26,33	p45	BLAST-2	4778	2208	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Ligation of the CD23 , p45 -LRB- BLAST-2 , EBVCS -RRB- antigen triggers the cell-cycle progression of activated B lymphocytes .
20351175	0	p45	64,67	Gata1	48,53	p45	Gata1	18022(Tax:10090)	14460(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis .
12586749	0	p45	28,31	KIP1	108,112	p45	KIP1	6502	1027	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of F-Box protein p45 -LRB- SKP2 -RRB- expression and stabilization of cyclin-dependent kinase inhibitor p27 -LRB- KIP1 -RRB- in vitamin_D analog-treated cancer cells .
12586749	0	p45	28,31	SKP2	32,36	p45	SKP2	6502	6502	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of F-Box protein p45 -LRB- SKP2 -RRB- expression and stabilization of cyclin-dependent kinase inhibitor p27 -LRB- KIP1 -RRB- in vitamin_D analog-treated cancer cells .
17302910	0	p45	0,3	ataxin-3	88,96	p45	ataxin-3	4778	4287	Gene	Gene	targets|nsubj|START_ENTITY targets|xcomp|END_ENTITY	p45 , an ATPase subunit of the 19S proteasome , targets the polyglutamine disease protein ataxin-3 to the proteasome .
23009195	0	p450c17	71,78	androgen_receptor	22,39	p450c17	androgen receptor	1586	367	Gene	Gene	proteins|nummod|START_ENTITY proteins|compound|END_ENTITY	Immunoreactivities of androgen_receptor , estrogen receptors , p450arom , p450c17 proteins in wild ground squirrels ovaries during the nonbreeding and breeding seasons .
21558372	0	p45NF-E2	0,8	Gcm1	19,23	p45NF-E2	Gcm1	18022(Tax:10090)	14531(Tax:10090)	Gene	Gene	represses|amod|START_ENTITY END_ENTITY|nsubj|represses	p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation , placental vascularization and embryonic growth .
12547193	0	p460	31,35	DNA-dependent_protein_kinase	52,80	p460	DNA-dependent protein kinase	5591	5591	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	Coordinated assembly of Ku and p460 subunits of the DNA-dependent_protein_kinase on DNA ends is necessary for XRCC4-ligase IV recruitment .
11485312	0	p47	86,89	CKII	29,33	p47	CKII	5341	1457	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Regulation of protein_kinase CKII by direct interaction with the C-terminal region of p47 -LRB- phox -RRB- .
19130504	0	p47	18,21	Nef	6,9	p47	Nef	5341	6285	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	HIV-1 Nef induces p47 -LRB- phox -RRB- phosphorylation leading to a rapid superoxide anion release from the U937 human monoblastic cell line .
26021615	0	p47	21,24	Park7	0,5	p47	Park7	17304(Tax:10090)	57320(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Park7 interacts with p47 -LRB- phox -RRB- to direct NADPH oxidase-dependent ROS production and protect against sepsis .
26021615	0	p47	21,24	Park7	0,5	p47	Park7	17304(Tax:10090)	57320(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Park7 interacts with p47 -LRB- phox -RRB- to direct NADPH oxidase-dependent ROS production and protect against sepsis .
11740866	0	p47	55,58	TNFalpha	0,8	p47	TNFalpha	5341	7124	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	TNFalpha activates c-Jun amino terminal kinase through p47 -LRB- phox -RRB- .
12732216	0	p47	43,46	phox	47,51	p47	phox	5341	5341	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Differentiation-dependent up-regulation of p47 -LRB- phox -RRB- gene transcription is associated with changes in PU .1 phosphorylation and increased binding affinity .
16752909	0	p47	106,109	phox	110,114	p47	phox	5341	5341	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Small-angle X-ray scattering reveals an extended organization for the autoinhibitory resting state of the p47 -LRB- phox -RRB- modular protein .
17922419	0	p47	45,48	phox	49,53	p47	phox	5341	5341	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	-LSB- The relationship between the exon 10 of the p47 -LRB- phox -RRB- polymorphism and stroke and the effect of the polymorphism on plasma lipid -RSB- .
10772875	0	p47-phox	31,39	NCF1	41,45	p47-phox	NCF1	653361	653361	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure of the human p47-phox -LRB- NCF1 -RRB- gene .
11166463	0	p47-phox	140,148	NCF1	155,159	p47-phox	NCF1	653361	653361	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational analysis of patients with p47-phox-deficient chronic_granulomatous_disease : The significance of recombination events between the p47-phox gene -LRB- NCF1 -RRB- and its highly homologous pseudogenes .
10891396	0	p47-phox	40,48	Ncf1	50,54	p47-phox	Ncf1	17969(Tax:10090)	17969(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the mouse p47-phox -LRB- Ncf1 -RRB- gene and comparative analysis of the mouse p47-phox -LRB- Ncf1 -RRB- gene to the human NCF1 gene .
10891396	0	p47-phox	99,107	Ncf1	109,113	p47-phox	Ncf1	17969(Tax:10090)	17969(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the mouse p47-phox -LRB- Ncf1 -RRB- gene and comparative analysis of the mouse p47-phox -LRB- Ncf1 -RRB- gene to the human NCF1 gene .
23119229	0	p47phox	19,26	NADPH_oxidase	61,74	p47phox	NADPH oxidase	653361	1536	Gene	Gene	Phosphorylation|nmod|START_ENTITY required|nsubjpass|Phosphorylation required|nmod|activation activation|compound|END_ENTITY	Phosphorylation of p47phox is required for receptor-mediated NADPH_oxidase / NOX2 activation in Epstein-Barr_virus-transformed human B lymphocytes .
23119229	0	p47phox	19,26	NOX2	75,79	p47phox	NOX2	653361	1536	Gene	Gene	Phosphorylation|nmod|START_ENTITY required|nsubjpass|Phosphorylation required|nmod|activation activation|compound|END_ENTITY	Phosphorylation of p47phox is required for receptor-mediated NADPH_oxidase / NOX2 activation in Epstein-Barr_virus-transformed human B lymphocytes .
15936744	0	p47phox	6,13	Ncf1	0,4	p47phox	Ncf1	114553(Tax:10116)	114553(Tax:10116)	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	Ncf1 -LRB- p47phox -RRB- polymorphism determines oxidative burst and the severity of arthritis in rats and mice .
17803994	0	p47phox	39,46	Nox2	50,54	p47phox	Nox2	653361	1536	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	p40phox as an alternative organizer to p47phox in Nox2 activation : a new mechanism involving an interaction with p22phox .
12663375	0	p47phox	51,58	angiotensin_II	93,107	p47phox	angiotensin II	653361	183	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nmod|END_ENTITY	c-Src induces phosphorylation and translocation of p47phox : role in superoxide generation by angiotensin_II in human vascular smooth muscle cells .
15618548	0	p47phox	0,7	angiotensin_II	136,150	p47phox	angiotensin II	653361	183	Gene	Gene	associates|amod|START_ENTITY oxidase|nsubj|associates oxidase|nmod|END_ENTITY	p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells : role in NAD -LRB- P -RRB- H oxidase regulation by angiotensin_II .
15775784	0	p47phox	42,49	angiotensin_II	137,151	p47phox	angiotensin II	653361	183	Gene	Gene	over-activation|nmod|START_ENTITY over-activation|parataxis|role role|nmod|END_ENTITY	Angiotensin_II-induced over-activation of p47phox in fibroblasts from hypertensives : which role in the enhanced ERK1/2 responsiveness to angiotensin_II ?
17374653	0	p47phox	105,112	angiotensin_II	124,138	p47phox	angiotensin II	114553(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Quercetin and isorhamnetin prevent endothelial_dysfunction , superoxide production , and overexpression of p47phox induced by angiotensin_II in rat aorta .
11258927	0	p47phox	149,156	p40phox	181,188	p47phox	p40phox	653361	4689	Gene	Gene	START_ENTITY|nmod|association association|nmod|END_ENTITY	Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox .
16040349	0	p47phox	15,22	p47phox	49,56	p47phox	p47phox	114553(Tax:10116)	653361	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of rat p47phox and comparison with human p47phox .
16040349	0	p47phox	49,56	p47phox	15,22	p47phox	p47phox	653361	114553(Tax:10116)	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of rat p47phox and comparison with human p47phox .
21930127	0	p48	39,42	ErbB3	16,21	p48	ErbB3	10379	2065	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Long isoform of ErbB3 binding protein , p48 , mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization .
9242679	0	p48	63,66	ISGF3	131,136	p48	ISGF3	10379	6772	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3 .
8990168	0	p48	65,68	ISGF3gamma	53,63	p48	ISGF3gamma	16391(Tax:10090)	16391(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Interferon_gamma-induced transcription of the murine ISGF3gamma -LRB- p48 -RRB- gene is mediated by novel factors .
9207073	0	p48	32,35	ISGF3gamma	37,47	p48	ISGF3gamma	16391(Tax:10090)	16391(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The interferon-inducible murine p48 -LRB- ISGF3gamma -RRB- gene is regulated by protooncogene c-myc .
9632823	0	p48	0,3	UV-damaged-DNA_binding_factor	16,45	p48	UV-damaged-DNA binding factor	10379	1642	Gene	Gene	Activates|nsubj|START_ENTITY Activates|dobj|END_ENTITY	p48 Activates a UV-damaged-DNA_binding_factor and is defective in xeroderma_pigmentosum group E cells that lack binding activity .
24448807	0	p50	164,167	BMP	86,89	p50	BMP	4790	649	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Transcriptional repression of the transforming_growth_factor_b -LRB- TGF-b -RRB- Pseudoreceptor BMP and activin membrane-bound inhibitor -LRB- BAMBI -RRB- by Nuclear Factor kB -LRB- NF-kB -RRB- p50 enhances TGF-b signaling in hepatic stellate cells .
16519794	0	p50	56,59	CD34	64,68	p50	CD34	4790	947	Gene	Gene	expression|appos|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Enhanced expression of mRNA for nuclear factor kappaB1 -LRB- p50 -RRB- in CD34 + cells of the bone marrow in rheumatoid_arthritis .
12522211	0	p50	67,70	DNA_polymerase_delta	82,102	p50	DNA polymerase delta	4790	5424	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Identification of a novel protein , PDIP38 , that interacts with the p50 subunit of DNA_polymerase_delta and proliferating_cell_nuclear_antigen .
20226764	0	p50	63,66	Insulin_receptor_substrate-3	0,28	p50	Insulin receptor substrate-3	4790	442338	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Insulin_receptor_substrate-3 , interacting with Bcl-3 , enhances p50 NF-kappaB activity .
27039297	0	p50	100,103	Leucine-rich_repeat_kinase_2	12,40	p50	Leucine-rich repeat kinase 2	4790	120892	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Erratum to : Leucine-rich_repeat_kinase_2 positively regulates inflammation and down-regulates NF-kB p50 signaling in cultured microglia cells .
11714266	0	p50	25,28	NF-kappaB	40,49	p50	NF-kappaB	4790	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Glutathionylation of the p50 subunit of NF-kappaB : a mechanism for redox-induced inhibition of DNA binding .
15201435	0	p50	121,124	NF-kappaB	161,170	p50	NF-kappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Effect of 2,2 ' ,4,4 ' ,5,5 ' - hexachlorobiphenyl -LRB- PCB-153 -RRB- on hepatocyte proliferation and apoptosis in mice deficient in the p50 subunit of the transcription factor NF-kappaB .
16793936	0	p50	70,73	NF-kappaB	60,69	p50	NF-kappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Spontaneous , homeostatic , and inflammation-induced sleep in NF-kappaB p50 knockout mice .
18694964	0	p50	4,7	NF-kappaB	19,28	p50	NF-kappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p50 subunit of NF-kappaB is critical for in vivo clearance of the noninvasive enteric pathogen Citrobacter_rodentium .
19806632	0	p50	26,29	NF-kappaB	30,39	p50	NF-kappaB	4790	4790	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Virtual screening against p50 NF-kappaB transcription factor for the identification of inhibitors of the NF-kappaB-DNA interaction and expression of NF-kappaB upregulated genes .
20086086	0	p50	14,17	NF-kappaB	4,13	p50	NF-kappaB	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	The NF-kappaB p50 subunit is protective during intestinal Entamoeba_histolytica infection of 129 and C57BL/6 mice .
15364010	0	p50	31,34	NF-kappaB1	19,29	p50	NF-kappaB1	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Protective role of NF-kappaB1 -LRB- p50 -RRB- in experimental_pneumococcal_meningitis .
1547506	0	p50	103,106	NF-kappa_B	107,117	p50	NF-kappa B	4790	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa_B subunit .
1740105	0	p50	62,65	NF-kappa_B	77,87	p50	NF-kappa B	4790	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa_B indicates that it participates in its own regulation .
2203532	0	p50	15,18	NF-kappa_B	42,52	p50	NF-kappa B	44086(Tax:7227)	41087(Tax:7227)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Cloning of the p50 DNA binding subunit of NF-kappa_B : homology to rel and dorsal .
8056331	0	p50	78,81	NF-kappa_B	93,103	p50	NF-kappa B	4790	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa_B in vitro .
8416374	0	p50	27,30	NF-kappa_B	42,52	p50	NF-kappa B	4790	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Mutational analysis of the p50 subunit of NF-kappa_B and inhibition of NF-kappa_B activity by trans-dominant p50 mutants .
8065920	0	p50	82,85	NF_kappa_B	97,107	p50	NF kappa B	4790	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Sequence-specific interaction of alpha-beta-anomeric double-stranded DNA with the p50 subunit of NF_kappa_B : application to the decoy approach .
12801933	0	p50	50,53	NF_kappa_B1	37,48	p50	NF kappa B1	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	The MEK/ERK pathway acts upstream of NF_kappa_B1 -LRB- p50 -RRB- homodimer activity and Bcl-2 expression in a murine B-cell_lymphoma cell line .
18617174	0	p50	27,30	Nuclear_Factor-kappa_B	4,26	p50	Nuclear Factor-kappa B	18033(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	The Nuclear_Factor-kappa_B p50 subunit is involved in flow-induced outward arterial remodeling .
19460845	0	p50	85,88	Platelet-activating_factor	0,26	p50	Platelet-activating factor	18033(Tax:10090)	109585(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Platelet-activating_factor induces the processing of nuclear factor-kappaB p105 into p50 , which mediates acute bowel_injury in mice .
16479163	0	p50	31,34	p21	22,25	p50	p21	4790	644914	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of p21 with p50 , the small subunit of human DNA polymerase delta .
8666233	0	p50Cdc37	10,18	Hsp90	60,65	p50Cdc37	Hsp90	11140	3320	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4 .
16331259	0	p50RhoGAP	62,71	RhoA	89,93	p50RhoGAP	RhoA	392	387	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	BNIP-Salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP-2 and Cdc42GAP homology domain .
8890164	0	p50csk	50,56	PEP	91,94	p50csk	PEP	1445	5047	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Association of inhibitory tyrosine protein kinase p50csk with protein_tyrosine_phosphatase PEP in T cells and other hemopoietic cells .
9287362	0	p50csk	35,41	PTP-PEST	90,98	p50csk	PTP-PEST	1445	5782	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	Inhibitory tyrosine protein kinase p50csk is associated with protein-tyrosine phosphatase PTP-PEST in hemopoietic and non-hemopoietic cells .
11340630	0	p51	25,28	p53	58,61	p51	p53	8626	7157	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Mutation analysis of the p51 gene and correlation between p53 , p73 , and p51 expressions in prostatic_carcinoma .
16613850	0	p52	67,70	Akt	0,3	p52	Akt	18034(Tax:10090)	11651(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Akt regulates basal and induced processing of NF-kappaB2 -LRB- p100 -RRB- to p52 .
12374738	0	p52	52,55	CD40	0,4	p52	CD40	18034(Tax:10090)	21939(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	CD40 regulates the processing of NF-kappaB2_p100 to p52 .
17003035	0	p52	38,41	IkappaB_kinase_epsilon	0,22	p52	IkappaB kinase epsilon	4791	9641	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	IkappaB_kinase_epsilon interacts with p52 and promotes transactivation via p65 .
23699654	0	p52	7,10	NF-kB2	0,6	p52	NF-kB2	4791	4791	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	NF-kB2 / p52 induces resistance to enzalutamide in prostate_cancer : role of androgen_receptor and its variants .
17339330	0	p52	82,85	TFIIH	97,102	p52	TFIIH	39688(Tax:7227)	39202(Tax:7227)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome_fragility .
19665990	0	p52	22,25	TRIM31	0,6	p52	TRIM31	4791	11074	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TRIM31 interacts with p52 -LRB- Shc -RRB- and inhibits Src-induced anchorage-independent growth .
20388792	0	p52	59,62	androgen_receptor	27,44	p52	androgen receptor	4791	367	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Aberrant activation of the androgen_receptor by NF-kappaB2 / p52 in prostate_cancer cells .
12808109	0	p52	113,116	histone_deacetylase_1	140,161	p52	histone deacetylase 1	4791	3065	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	p53 represses cyclin_D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone_deacetylase_1 .
14576817	0	p52	110,113	latent_infection_membrane_protein_1	27,62	p52	latent infection membrane protein 1	4791	9260	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Epstein-Barr_virus-encoded latent_infection_membrane_protein_1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway .
18812399	0	p53	36,39	14-3-3	0,6	p53	14-3-3	7157	10971	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers .
22192357	0	p53	23,26	14-3-3	0,6	p53	14-3-3	7157	10971	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	14-3-3 regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast_cancer cells via Akt inactivation .
18339856	0	p53	27,30	14-3-3_zeta	0,11	p53	14-3-3 zeta	7157	7534	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	14-3-3_zeta down-regulates p53 in mammary epithelial cells and confers luminal filling .
21945951	0	p53	22,25	AICAR	53,58	p53	AICAR	7157	471	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases .
18997814	0	p53	81,84	AID	57,60	p53	AID	22059(Tax:10090)	11628(Tax:10090)	Gene	Gene	mutations|compound|START_ENTITY causing|dobj|mutations triggered|xcomp|causing triggered|nmod|END_ENTITY	A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations .
26622562	0	p53	5,8	AID	0,3	p53	AID	7157	57379	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	AID , p53 and MLH1 expression in early gastric_neoplasms and the correlation with the background mucosa .
15880691	0	p53	182,185	AIF	94,97	p53	AIF	7157	9131	Gene	Gene	ERK|nmod|START_ENTITY effect|nmod|ERK lack|nmod|effect mediated|nsubj|lack leads|parataxis|mediated leads|xcomp|apoptosis_inducing_factor apoptosis_inducing_factor|dobj|apoptosis apoptosis|appos|END_ENTITY	Inhibition of extracellular_signal_regulated_kinase -LRB- ERK -RRB- leads to apoptosis_inducing_factor -LRB- AIF -RRB- mediated apoptosis in epithelial breast_cancer cells : the lack of effect of ERK in p53 mediated copper induced apoptosis .
16729031	0	p53	32,35	AIF	14,17	p53	AIF	7157	9131	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of AIF expression by p53 .
16849534	0	p53	51,54	AIMP3	0,5	p53	AIMP3	7157	9521	Gene	Gene	activation|compound|START_ENTITY disrupts|dobj|activation disrupts|nsubj|END_ENTITY	AIMP3 haploinsufficiency disrupts oncogene-induced p53 activation and genomic stability .
25643698	0	p53	63,66	AIMP3	12,17	p53	AIMP3	7157	9521	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Correction : AIMP3 Haploinsufficiency Disrupts Oncogene-Induced p53 Activation and Genomic Stability .
24140838	0	p53	37,40	AKR1B10	0,7	p53	AKR1B10	7157	57016	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	AKR1B10 , a transcriptional target of p53 , is downregulated in colorectal_cancers associated with poor prognosis .
18079115	0	p53	121,124	AMP-activated_protein_kinase	14,42	p53	AMP-activated protein kinase	7157	5563	Gene	Gene	hyper-induction|nmod|START_ENTITY apoptosis|nmod|hyper-induction sensitizes|nmod|apoptosis sensitizes|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of AMP-activated_protein_kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53 .
20880848	0	p53	110,113	AMP-activated_protein_kinase	14,42	p53	AMP-activated protein kinase	7157	5563	Gene	Gene	activation|compound|START_ENTITY cells|nmod|activation apoptosis|nmod|cells contributes|nmod|apoptosis contributes|nsubj|Activation Activation|nmod|END_ENTITY	Activation of AMP-activated_protein_kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition .
24190973	0	p53	37,40	AMP-activated_protein_kinase	0,28	p53	AMP-activated protein kinase	7157	5563	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	AMP-activated_protein_kinase induces p53 by phosphorylating MDMX and inhibiting its activity .
26034977	0	p53	39,42	AMP-activated_protein_kinase	51,79	p53	AMP-activated protein kinase	7157	5564	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Matrine-induced autophagy regulated by p53 through AMP-activated_protein_kinase in human hepatoma cells .
26034977	0	p53	39,42	AMP-activated_protein_kinase	51,79	p53	AMP-activated protein kinase	7157	5564	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Matrine-induced autophagy regulated by p53 through AMP-activated_protein_kinase in human hepatoma cells .
16636674	0	p53	55,58	AP-2alpha	0,9	p53	AP-2alpha	7157	7020	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	AP-2alpha and AP-2gamma are transcriptional targets of p53 in human breast_carcinoma cells .
18208837	0	p53	88,91	AP-endonuclease	24,39	p53	AP-endonuclease	7157	328	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the human AP-endonuclease -LRB- APE1/Ref -1 -RRB- expression by the tumor suppressor p53 in response to DNA damage .
11559530	0	p53	38,41	APAF-1	0,6	p53	APAF-1	7157	317	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis .
16331630	0	p53	82,85	APAF-1	13,19	p53	APAF-1	7157	317	Gene	Gene	mutation|compound|START_ENTITY case|nmod|mutation Silencing|nmod|case Silencing|nmod|END_ENTITY	Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation .
11591730	0	p53	42,45	APAF1	0,5	p53	APAF1	7157	317	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death .
15389287	0	p53	98,101	APAF1	64,69	p53	APAF1	7157	317	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|gene gene|acl|located located|nmod|locus locus|compound|END_ENTITY	A highly conserved proapoptotic gene , IKIP , located next to the APAF1 gene locus , is regulated by p53 .
17533371	0	p53	53,56	APLP1	36,41	p53	APLP1	7157	333	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress .
23524907	0	p53	38,41	ARID1A	56,62	p53	ARID1A	7157	8289	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The clinicopathologic significance of p53 and BAF-250a -LRB- ARID1A -RRB- expression in clear cell carcinoma_of_the_endometrium .
23887303	0	p53	66,69	ARID1A	0,6	p53	ARID1A	7157	8289	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|loss loss|compound|END_ENTITY	ARID1A loss correlates with mismatch_repair_deficiency and intact p53 expression in high-grade endometrial_carcinomas .
18793611	0	p53	0,3	ASPP2	22,27	p53	ASPP2	7157	7159	Gene	Gene	binds|compound|START_ENTITY END_ENTITY|nsubj|binds	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
17700520	0	p53	81,84	ATF-2	0,5	p53	ATF-2	22060(Tax:10090)	11909(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	ATF-2 controls transcription of Maspin and GADD45_alpha genes independently from p53 to suppress mammary_tumors .
10082548	0	p53	51,54	ATM	15,18	p53	ATM	7157	472	Gene	Gene	protein|compound|START_ENTITY Requirement|nmod|protein Requirement|nmod|END_ENTITY	Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaks .
11468183	0	p53	0,3	ATM	72,75	p53	ATM	7157	472	Gene	Gene	dysfunction|compound|START_ENTITY dysfunction|dep|inactivation inactivation|nmod|END_ENTITY	p53 dysfunction in B-cell_chronic_lymphocytic_leukemia : inactivation of ATM as an alternative to TP53 mutation .
11526498	0	p53	14,17	ATM	52,55	p53	ATM	7157	472	Gene	Gene	activity|compound|START_ENTITY Activation|nmod|activity requires|nsubj|Activation requires|dobj|domain domain|nmod:poss|END_ENTITY	Activation of p53 transcriptional activity requires ATM 's kinase domain and multiple N-terminal serine residues of p53 .
12890678	0	p53	14,17	ATM	132,135	p53	ATM	7157	472	Gene	Gene	Activation|nmod|START_ENTITY involves|nsubj|Activation involves|dobj|mutated mutated|appos|END_ENTITY	Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia_telangiectasia mutated -LRB- ATM -RRB- kinase activation .
15097860	0	p53	52,55	ATM	14,17	p53	ATM	7157	472	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|protein protein|amod|END_ENTITY	Expression of ATM protein and its relationship with p53 in pancreatic_carcinoma with tissue array .
16152627	0	p53	93,96	ATM	32,35	p53	ATM	7157	472	Gene	Gene	stabilize|dobj|START_ENTITY signaling|xcomp|stabilize END_ENTITY|acl|signaling	Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells .
16163388	0	p53	61,64	ATM	0,3	p53	ATM	7157	472	Gene	Gene	activation|compound|START_ENTITY contribute|nmod|activation contribute|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage .
16849690	0	p53	125,128	ATM	29,32	p53	ATM	7157	472	Gene	Gene	activity|nmod|START_ENTITY inactivation|nmod|activity cleavage|dep|inactivation cleavage|nmod|END_ENTITY	Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis : inactivation of its kinase activity toward p53 .
17292432	0	p53	19,22	ATM	107,110	p53	ATM	7157	472	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|dep|involvement involvement|nmod|pathway pathway|compound|END_ENTITY	Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate : involvement of ATM pathway .
17417627	0	p53	0,3	ATM	79,82	p53	ATM	22060(Tax:10090)	11920(Tax:10090)	Gene	Gene	cancer|nummod|START_ENTITY mutants|nsubj|cancer mutants|xcomp|induce induce|advcl|inactivating inactivating|dobj|END_ENTITY	p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM .
18344416	0	p53	37,40	ATM	121,124	p53	ATM	7157	472	Gene	Gene	roles|nmod|START_ENTITY roles|dep|END_ENTITY	Differential roles of ATR and ATM in p53 , Chk1 , and histone_H2AX phosphorylation in response to hyperoxia : ATR-dependent ATM activation .
19816404	0	p53	14,17	ATM	0,3	p53	ATM	7157	472	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	ATM activates p53 by regulating MDM2 oligomerization and E3 processivity .
20081365	0	p53	13,16	ATM	34,37	p53	ATM	7157	472	Gene	Gene	Mechanism|nmod|START_ENTITY stabilization|nsubj|Mechanism stabilization|nmod|END_ENTITY	Mechanism of p53 stabilization by ATM after DNA damage .
21546907	0	p53	48,51	ATM	102,105	p53	ATM	7157	472	Gene	Gene	potentiates|compound|START_ENTITY expression|nmod|potentiates Abrogation|nmod|expression apoptosis|nsubj|Abrogation apoptosis|dobj|induction induction|nmod|activation activation|nmod|END_ENTITY	Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX .
22576881	0	p53	42,45	ATM	0,3	p53	ATM	7157	472	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage .
22893124	0	p53	34,37	ATM	23,26	p53	ATM	7157	472	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage .
23405218	0	p53	65,68	ATM	27,30	p53	ATM	7157	472	Gene	Gene	activation|compound|START_ENTITY contributes|nmod|activation contributes|nsubj|Phosphorylation Phosphorylation|nmod|Daxx Daxx|nmod|END_ENTITY	Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation .
23549171	0	p53	30,33	ATM	0,3	p53	ATM	7157	472	Gene	Gene	control|dobj|START_ENTITY hnRNPK|xcomp|control hnRNPK|nsubj|targets targets|compound|END_ENTITY	ATM targets hnRNPK to control p53 .
24813712	0	p53	23,26	ATM	60,63	p53	ATM	7157	472	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	HDMX folds the nascent p53 mRNA following activation by the ATM kinase .
24841718	0	p53	44,47	ATM	4,7	p53	ATM	7157	472	Gene	Gene	correlates|compound|START_ENTITY expression|nmod|correlates END_ENTITY|dobj|expression	Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric_cancer cell lines .
9733514	0	p53	28,31	ATM	35,38	p53	ATM	7157	472	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Enhanced phosphorylation of p53 by ATM in response to DNA damage .
9733515	0	p53	74,77	ATM	18,21	p53	ATM	7157	472	Gene	Gene	radiation|nmod|START_ENTITY ionizing|dobj|radiation kinase|advcl|ionizing kinase|nsubj|Activation Activation|nmod|END_ENTITY	Activation of the ATM kinase by ionizing radiation and phosphorylation of p53 .
23678008	0	p53	0,3	ATPase	32,38	p53	ATPase	7157	1769	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|END_ENTITY	p53 suppresses BRCA2-stimulated ATPase and strand exchange functions of human RAD51 .
10435622	0	p53	88,91	ATR	42,45	p53	ATR	7157	545	Gene	Gene	phosphorylation|nmod|START_ENTITY mediates|dobj|phosphorylation mediates|nsubj|END_ENTITY	The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53 .
11711532	0	p53	24,27	ATR	0,3	p53	ATR	7157	545	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint .
14654783	0	p53	65,68	ATR	43,46	p53	ATR	7157	545	Gene	Gene	export|compound|START_ENTITY attenuation|nmod|export phosphorylation|nmod|attenuation phosphorylation|nmod|END_ENTITY	Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export .
18032786	0	p53	127,130	ATR	153,156	p53	ATR	7157	545	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nmod|activation activation|nmod|END_ENTITY	The increase of cell-membranous phosphatidylcholines containing polyunsaturated_fatty_acid residues induces phosphorylation of p53 through activation of ATR .
18344416	0	p53	37,40	ATR	22,25	p53	ATR	7157	545	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Differential roles of ATR and ATM in p53 , Chk1 , and histone_H2AX phosphorylation in response to hyperoxia : ATR-dependent ATM activation .
18606816	0	p53	109,112	ATR	77,80	p53	ATR	7157	545	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|compound|END_ENTITY	Hepatitis_B_virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis .
21258400	0	p53	39,42	ATR	0,3	p53	ATR	7157	545	Gene	Gene	manner|compound|START_ENTITY resistance|nmod|manner mediates|dobj|resistance mediates|nsubj|END_ENTITY	ATR mediates cisplatin resistance in a p53 genotype-specific manner .
21643554	0	p53	37,40	ATR	131,134	p53	ATR	7157	545	Gene	Gene	cells|nummod|START_ENTITY responses|nmod|cells independent|nsubj|responses independent|nmod|checkpoint checkpoint|compound|END_ENTITY	Differential DNA damage responses in p53 proficient and deficient cells : cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53-deficient_lung_cancer cells .
9925639	0	p53	60,63	ATR	11,14	p53	ATR	7157	545	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for ATR in the DNA damage-induced phosphorylation of p53 .
15933712	0	p53	62,65	Activating_transcription_factor_3	0,33	p53	Activating transcription factor 3	22060(Tax:10090)	11910(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Activating_transcription_factor_3 , a stress sensor , activates p53 by blocking its ubiquitination .
20167600	0	p53	44,47	Activating_transcription_factor_3	0,33	p53	Activating transcription factor 3	7157	467	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Activating_transcription_factor_3 activates p53 by preventing E6-associated_protein from binding to E6 .
18008140	0	p53	29,32	Annexin_A2	15,25	p53	Annexin A2	7157	302	Gene	Gene	induced|compound|START_ENTITY END_ENTITY|nmod|induced	Involvement of Annexin_A2 in p53 induced apoptosis in lung_cancer .
26819684	0	p53	105,108	Annexin_V	94,103	p53	Annexin V	301300(Tax:10116)	25673(Tax:10116)	Gene	Gene	Levels|dep|START_ENTITY Levels|compound|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
11423996	0	p53	45,48	Apaf-1	83,89	p53	Apaf-1	7157	317	Gene	Gene	apoptosis|nummod|START_ENTITY involved|nmod|apoptosis genes|acl|involved analysis|nmod|genes analysis|dep|activation activation|nmod|END_ENTITY	DNA microarray analysis of genes involved in p53 mediated apoptosis : activation of Apaf-1 .
12883670	0	p53	51,54	Apaf-1	30,36	p53	Apaf-1	22060(Tax:10090)	11783(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Tissue-specific regulation of Apaf-1 expression by p53 .
16021178	0	p53	0,3	Apaf-1	5,11	p53	Apaf-1	7157	317	Gene	Gene	START_ENTITY|appos|-9 -9|amod|END_ENTITY	p53 , Apaf-1 , caspase-3 , _ and _ -9 are dispensable for Cdk5 activation during cell death .
17361096	0	p53	109,112	Apaf1	0,5	p53	Apaf1	7157	317	Gene	Gene	mutation|compound|START_ENTITY correlated|nmod|mutation correlated|nsubjpass|END_ENTITY	Apaf1 in chronic_myelogenous_leukemia -LRB- CML -RRB- progression : reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis .
17361096	0	p53	109,112	Apaf1	65,70	p53	Apaf1	7157	317	Gene	Gene	mutation|compound|START_ENTITY correlated|nmod|mutation correlated|nsubjpass|Apaf1 Apaf1|nmod|progression progression|dep|expression expression|amod|END_ENTITY	Apaf1 in chronic_myelogenous_leukemia -LRB- CML -RRB- progression : reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis .
22334068	0	p53	19,22	Apak	0,4	p53	Apak	7157	147923	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis .
18171989	0	p53	50,53	Ataxia-telangiectasia_mutated	0,29	p53	Ataxia-telangiectasia mutated	22060(Tax:10090)	11920(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|nsubjpass|END_ENTITY	Ataxia-telangiectasia_mutated is not required for p53 induction and apoptosis in irradiated epithelial tissues .
22499945	0	p53	15,18	Atg7	0,4	p53	Atg7	22060(Tax:10090)	74244(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress .
10082576	0	p53	23,26	Atm	0,3	p53	Atm	22060(Tax:10090)	11920(Tax:10090)	Gene	Gene	apoptosis|compound|START_ENTITY dispensable|nmod|apoptosis dispensable|nsubj|END_ENTITY	Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction .
15642165	0	p53	74,77	Atm	0,3	p53	Atm	22060(Tax:10090)	11920(Tax:10090)	Gene	Gene	heterozygous|compound|START_ENTITY mammary_carcinomas|nmod|heterozygous mice|amod|mammary_carcinomas development|nmod|mice enhances|dobj|development enhances|nsubj|END_ENTITY	Atm heterozygous_deficiency enhances development of mammary_carcinomas in p53 heterozygous knockout mice .
18583527	0	p53	21,24	Atm	43,46	p53	Atm	22060(Tax:10090)	11920(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY suppression|nmod|absence absence|nmod|END_ENTITY	Tumor suppression by p53 in the absence of Atm .
9632822	0	p53	15,18	Atm	68,71	p53	Atm	22060(Tax:10090)	11920(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|defects defects|nmod|END_ENTITY	Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm - / - mice .
22894933	0	p53	0,3	Aurora_A	25,33	p53	Aurora A	7157	6790	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p53 negatively regulates Aurora_A via both transcriptional and posttranslational regulation .
17878219	0	p53	21,24	BAF53	0,5	p53	BAF53	7157	86	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BAF53 interacts with p53 and functions in p53-mediated p21-gene transcription .
18303029	0	p53	22,25	BAF60a	0,6	p53	BAF60a	7157	6602	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BAF60a interacts with p53 to recruit the SWI/SNF complex .
10352342	0	p53	0,3	BAK	13,16	p53	BAK	7157	578	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|compound|END_ENTITY	p53 enhances BAK and CD95 expression in human malignant_glioma cells but does not enhance CD95L-induced apoptosis .
18524770	0	p53	26,29	BAK	19,22	p53	BAK	7157	578	Gene	Gene	utilizes|compound|START_ENTITY END_ENTITY|nmod|utilizes	Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain .
18524770	0	p53	65,68	BAK	19,22	p53	BAK	7157	578	Gene	Gene	domain|compound|START_ENTITY residues|nmod|domain conserved|dobj|residues conserved|nsubj|Oligomerization Oligomerization|nmod|END_ENTITY	Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain .
11278953	0	p53	29,32	BAX	93,96	p53	BAX	7157	581	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|cofactor cofactor|acl|activate activate|dobj|promoter promoter|compound|END_ENTITY	The tumor suppressor protein p53 requires a cofactor to activate transcriptionally the human BAX promoter .
17426704	0	p53	11,14	BAX	187,190	p53	BAX	7157	581	Gene	Gene	Studies|nmod|START_ENTITY Studies|dep|impact impact|nmod|END_ENTITY	Studies on p53 , BAX and Bcl-2 protein expression and microsatellite instability in stage III -LRB- UICC -RRB- colon_cancer treated by adjuvant chemotherapy : major prognostic impact of proapoptotic BAX .
18793611	0	p53	0,3	BAX	73,76	p53	BAX	7157	581	Gene	Gene	binds|compound|START_ENTITY ASPP2|nsubj|binds ASPP2|nmod|activation activation|compound|END_ENTITY	p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation .
23071787	0	p53	22,25	BAX	104,107	p53	BAX	7157	581	Gene	Gene	polymorphism|compound|START_ENTITY allele|nmod|polymorphism associated|nsubjpass|allele associated|nmod|expression expression|nmod|END_ENTITY	The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21 , and increased breast_cancer risk .
23836939	0	p53	13,16	BAX	32,35	p53	BAX	7157	581	Gene	Gene	START_ENTITY|amod|binding binding|nmod|element element|compound|END_ENTITY	Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion .
26236013	0	p53	48,51	BAX	61,64	p53	BAX	7157	581	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis .
9826721	0	p53	97,100	BAX	115,118	p53	BAX	7157	581	Gene	Gene	failure|nmod|START_ENTITY associated|nmod|failure associated|xcomp|induce induce|dobj|expression expression|appos|END_ENTITY	The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 -LRB- BAX -RRB- expression .
10891529	0	p53	138,141	BCL-2	59,64	p53	BCL-2	7157	596	Gene	Gene	transformed|nmod|START_ENTITY transformed|nsubj|synergize synergize|nmod|regulation regulation|nmod|induction induction|compound|END_ENTITY	Theophylline and cisplatin synergize in down regulation of BCL-2 induction of apoptosis in human granulosa cells transformed by a mutated p53 -LRB- p53 val135 -RRB- and Ha-ras oncogene .
10891529	0	p53	143,146	BCL-2	59,64	p53	BCL-2	7157	596	Gene	Gene	val135|nummod|START_ENTITY p53|appos|val135 transformed|nmod|p53 transformed|nsubj|synergize synergize|nmod|regulation regulation|nmod|induction induction|compound|END_ENTITY	Theophylline and cisplatin synergize in down regulation of BCL-2 induction of apoptosis in human granulosa cells transformed by a mutated p53 -LRB- p53 val135 -RRB- and Ha-ras oncogene .
11407516	0	p53	0,3	BCL-2	5,10	p53	BCL-2	7157	596	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	p53 , BCL-2 , and Ki-67 expression according to tumor response after concurrent chemoradiotherapy for advanced rectal_cancer .
16228292	0	p53	108,111	BCL-2	0,5	p53	BCL-2	7157	596	Gene	Gene	antisense|nmod|START_ENTITY antisense|nsubj|END_ENTITY	BCL-2 antisense and cisplatin combination treatment of MCF-7_breast_cancer cells with or without functional p53 .
9779489	0	p53	83,86	BCL-2	88,93	p53	BCL-2	7157	596	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Spontaneous programmed cell death in infiltrating duct_carcinoma : association with p53 , BCL-2 , hormone receptors and tumor proliferation .
16006797	0	p53	129,132	BCL2	140,144	p53	BCL2	7157	596	Gene	Gene	neu|compound|START_ENTITY neu|dep|END_ENTITY	An immunohistochemical comparison between low-grade and high-grade ovarian_serous_carcinomas : significantly higher expression of p53 , MIB1 , BCL2 , HER-2 / neu , and C-KIT in high-grade neoplasms .
15577913	0	p53	35,38	BCL6	4,8	p53	BCL6	7157	604	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|proto-oncogene proto-oncogene|compound|END_ENTITY	The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells .
16249378	0	p53	21,24	BCL6	0,4	p53	BCL6	7157	604	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	BCL6 is regulated by p53 through a response element frequently disrupted in B-cell_non-Hodgkin_lymphoma .
19405121	0	p53	50,53	BCL6	0,4	p53	BCL6	22060(Tax:10090)	12053(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY cooperates|nmod|stimulation cooperates|nummod|END_ENTITY	BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells .
12402042	0	p53	18,21	BID	0,3	p53	BID	22059(Tax:10090)	12122(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	BID regulation by p53 contributes to chemosensitivity .
21856084	0	p53	0,3	BID	25,28	p53	BID	7157	637	Gene	Gene	facilitates|compound|START_ENTITY BH3-only|nsubj|facilitates BH3-only|dobj|export export|compound|END_ENTITY	p53 facilitates BH3-only BID nuclear export to induce apoptosis in the irrepairable DNA damage response .
22869143	0	p53	38,41	BMK1	0,4	p53	BMK1	7157	5598	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction .
21792176	0	p53	0,3	BNIP3	24,29	p53	BNIP3	30590(Tax:7955)	336116(Tax:7955)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|expression expression|compound|END_ENTITY	p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death .
12548593	0	p53	57,60	BRCA1	19,24	p53	BRCA1	7157	672	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast_carcinoma : 10-year follow up data .
19448667	0	p53	73,76	BRG1	41,45	p53	BRG1	7157	6597	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells .
17690688	0	p53	67,70	BTG3	31,35	p53	BTG3	7157	10950	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1 .
26398519	0	p53	95,98	BUB3	84,88	p53	BUB3	7157	9184	Gene	Gene	Ki67|dep|START_ENTITY Ki67|compound|END_ENTITY	In situ carcinoma developed over_oral_lichen_planus : a case report with analysis of BUB3 , p16 , p53 , Ki67 and SOX4 expression .
11707401	0	p53	98,101	Bag-1	14,19	p53	Bag-1	7157	573	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Co-chaperones Bag-1 , Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53 .
15077116	0	p53	14,17	Bak	28,31	p53	Bak	7157	578	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex .
22354970	0	p53	30,33	Bak	118,121	p53	Bak	7157	578	Gene	Gene	START_ENTITY|acl:relcl|mediated mediated|nmod|derepression derepression|nmod|protein protein|compound|END_ENTITY	p14 -LRB- ARF -RRB- - induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins .
24633417	0	p53	24,27	Bak	94,97	p53	Bak	7157	578	Gene	Gene	Delivery|nmod|START_ENTITY subdomain|nsubj|Delivery subdomain|nmod|signals signals|nmod|END_ENTITY	Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax .
10049778	0	p53	33,36	Bax	109,112	p53	Bax	22060(Tax:10090)	12028(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|induction induction|nmod|apoptosis apoptosis|nmod|END_ENTITY	Effects of wild-type and mutated p53 and Id proteins on the induction of apoptosis by adenovirus E1A , c-Myc , Bax , and Nip3 in p53 null mouse cerebellum cells .
10200513	0	p53	13,16	Bax	77,80	p53	Bax	7157	581	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO -1 by irradiation and ara-C treatment .
10641752	0	p53	7,10	Bax	26,29	p53	Bax	7157	581	Gene	Gene	protein|compound|START_ENTITY protein|dep|ratios ratios|amod|END_ENTITY	Mutant p53 protein , Bcl-2 / Bax ratios and apoptosis in paediatric acute_lymphoblastic_leukaemia .
10741712	0	p53	82,85	Bax	44,47	p53	Bax	7157	581	Gene	Gene	transfer|compound|START_ENTITY mediators|nmod|transfer mediators|dobj|END_ENTITY	Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung_cancer cells .
10873563	0	p53	60,63	Bax	40,43	p53	Bax	7157	581	Gene	Gene	hepatocellular_carcinomas|compound|START_ENTITY Downregulation|nmod|hepatocellular_carcinomas Downregulation|nmod|END_ENTITY	Downregulation of proapoptotic proteins Bax and Bcl-X -LRB- S -RRB- in p53 overexpressing hepatocellular_carcinomas .
10935506	0	p53	8,11	Bax	24,27	p53	Bax	22060(Tax:10090)	12028(Tax:10090)	Gene	Gene	response|compound|START_ENTITY Driving|dobj|response Driving|advcl|END_ENTITY	Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis .
11044365	0	p53	77,80	Bax	6,9	p53	Bax	7157	581	Gene	Gene	status|compound|START_ENTITY sensitivity|nmod|status predicts|dobj|sensitivity predicts|nsubj|ratio ratio|compound|END_ENTITY	Bcl-2 / Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status .
11299743	0	p53	62,65	Bax	0,3	p53	Bax	7157	581	Gene	Gene	association|nmod|START_ENTITY expression|dep|association expression|compound|END_ENTITY	Bax protein expression in colorectal_cancer : association with p53 , bcl-2 and patterns of relapse .
11694525	0	p53	122,125	Bax	105,108	p53	Bax	7157	581	Gene	Gene	PaCa-2|compound|START_ENTITY ratio|nmod|PaCa-2 ratio|compound|END_ENTITY	Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2 / Bax ratio in the p53 mutant pancreatic_cancer cell line MIA PaCa-2 .
11748232	0	p53	52,55	Bax	124,127	p53	Bax	7157	581	Gene	Gene	transactivation|amod|START_ENTITY transactivation|nmod|promoter promoter|compound|END_ENTITY	HMGB1 and HMGB2 cell-specifically down-regulate the p53 - and p73-dependent sequence-specific transactivation from the human Bax gene promoter .
12203124	0	p53	153,156	Bax	179,182	p53	Bax	7157	581	Gene	Gene	genes|nummod|START_ENTITY genes|acl|encoding encoding|dobj|END_ENTITY	The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21 -LRB- CIP1/Waf1 -RRB- .
14634288	0	p53	63,66	Bax	42,45	p53	Bax	7157	581	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|splicing splicing|nmod|gene gene|compound|END_ENTITY	Induction and alternative splicing of the Bax gene mediated by p53 in a transformed endothelial cell line .
15262986	0	p53	86,89	Bax	14,17	p53	Bax	7157	581	Gene	Gene	pathways|nummod|START_ENTITY Regulation|nmod|pathways Regulation|nmod|activation activation|compound|END_ENTITY	Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and - independent pathways .
15292938	0	p53	38,41	Bax	31,34	p53	Bax	7157	581	Gene	Gene	crypts|nummod|START_ENTITY END_ENTITY|nmod|crypts	Upregulation of p16 -LRB- INK4A -RRB- and Bax in p53 wild/p53-overexpressing crypts in ulcerative_colitis-associated_tumours .
18042550	0	p53	49,52	Bax	15,18	p53	Bax	7157	581	Gene	Gene	activity|nummod|START_ENTITY repressing|dobj|activity decreases|advcl|repressing decreases|dobj|expression expression|compound|END_ENTITY	DJ-1 decreases Bax expression through repressing p53 transcriptional activity .
19360319	0	p53	32,35	Bax	37,40	p53	Bax	7157	581	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
20043868	0	p53	35,38	Bax	68,71	p53	Bax	7157	581	Gene	Gene	Stabilization|nmod|START_ENTITY linked|nsubjpass|Stabilization linked|xcomp|END_ENTITY	Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis .
20546728	0	p53	73,76	Bax	44,47	p53	Bax	22060(Tax:10090)	12028(Tax:10090)	Gene	Gene	activating|dobj|START_ENTITY upregulates|advcl|activating upregulates|dobj|expression expression|compound|END_ENTITY	Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons .
20567883	0	p53	22,25	Bax	0,3	p53	Bax	7157	581	Gene	Gene	pathway|compound|START_ENTITY upregulated|nmod|pathway upregulated|nsubjpass|END_ENTITY	Bax is upregulated by p53 signal pathway in the SPE B-induced apoptosis .
21092747	0	p53	0,3	Bax	72,75	p53	Bax	22060(Tax:10090)	12028(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediates|nsubj|activation mediates|dobj|upregulation upregulation|nmod|expression expression|compound|END_ENTITY	p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons .
21462329	0	p53	4,7	Bax	10,13	p53	Bax	7157	581	Gene	Gene	-|compound|START_ENTITY -|appos|inhibition inhibition|amod|END_ENTITY	The p53 - , Bax - and p21-dependent inhibition of colon_cancer cell growth by 5-hydroxy_polymethoxyflavones .
21485723	0	p53	40,43	Bax	35,38	p53	Bax	7157	581	Gene	Gene	caspase-3|dep|START_ENTITY caspase-3|dep|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
26124546	0	p53	38,41	Bax	0,3	p53	Bax	301300(Tax:10116)	24887(Tax:10116)	Gene	Gene	unaltered|nsubj|START_ENTITY modulates|advcl|unaltered modulates|nsubj|END_ENTITY	Bax modulates neuronal survival while p53 is unaltered after Cytochrome C induced oxidative stress in the adult olfactory bulb in vivo .
26833308	0	p53	65,68	Bax	92,95	p53	Bax	7157	581	Gene	Gene	upregulation|compound|START_ENTITY upregulation|compound|END_ENTITY	GSIV serine/threonine kinase can induce apoptotic cell death via p53 and pro-apoptotic gene Bax upregulation in fish cells .
9000137	0	p53	24,27	Bax	59,62	p53	Bax	7157	581	Gene	Gene	Expression|nmod|START_ENTITY stimulates|nsubj|Expression stimulates|dobj|increase increase|nmod|END_ENTITY	Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells .
9373250	0	p53	56,59	Bax	140,143	p53	Bax	7157	581	Gene	Gene	conformation|nmod|START_ENTITY upregulates|dobj|conformation upregulates|nmod|expression expression|nmod|END_ENTITY	Thrombopoietin upregulates the promoter conformation of p53 in a proliferation-independent manner coincident with a decreased expression of Bax : potential mechanisms for survival enhancing effects .
9699956	0	p53	0,3	Bax	5,8	p53	Bax	7157	581	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	p53 , Bax and Bcl-2 expression , and apoptosis in gestational trophoblast of complete_hydatidiform_mole .
10037739	0	p53	14,17	Bcl-2	46,51	p53	Bcl-2	7157	596	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain .
10188857	0	p53	4,7	Bcl-2	33,38	p53	Bcl-2	7157	596	Gene	Gene	over-expression|compound|START_ENTITY over-expression|appos|accumulation accumulation|compound|END_ENTITY	Can p53 nuclear over-expression , Bcl-2 accumulation and PCNA status be of prognostic significance in high-risk superficial and invasive bladder_tumours ?
10329733	0	p53	0,3	Bcl-2	37,42	p53	Bcl-2	7157	596	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|nmod|promoter promoter|compound|END_ENTITY	p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor .
10362119	0	p53	36,39	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	protein|compound|START_ENTITY related|nmod|protein related|nsubj|expression expression|amod|END_ENTITY	Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic_carcinoma .
10597302	0	p53	195,198	Bcl-2	142,147	p53	Bcl-2	7157	596	Gene	Gene	independent|nmod|START_ENTITY Bcl-XL|nmod|independent Bcl-XL|dep|Induction Induction|nmod|pathways pathways|acl:relcl|regulated regulated|nmod|END_ENTITY	Induction of apoptosis in U937 human leukemia cells by suberoylanilide_hydroxamic_acid -LRB- SAHA -RRB- proceeds through pathways that are regulated by Bcl-2 / Bcl-XL , c-Jun , and p21CIP1 , but independent of p53 .
10641752	0	p53	7,10	Bcl-2	20,25	p53	Bcl-2	7157	596	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Mutant p53 protein , Bcl-2 / Bax ratios and apoptosis in paediatric acute_lymphoblastic_leukaemia .
11044365	0	p53	77,80	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	status|compound|START_ENTITY sensitivity|nmod|status predicts|dobj|sensitivity END_ENTITY|parataxis|predicts	Bcl-2 / Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status .
11519857	0	p53	29,32	Bcl-2	70,75	p53	Bcl-2	7157	596	Gene	Gene	accumulation|compound|START_ENTITY mutations|appos|accumulation mutations|appos|END_ENTITY	TP53 gene mutations , nuclear p53 accumulation , expression of Waf/p21 , Bcl-2 , and CD95 -LRB- APO-1 / Fas -RRB- proteins are not prognostic factors in de novo glioblastoma multiforme .
11532334	0	p53	72,75	Bcl-2	0,5	p53	Bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	accumulation|compound|START_ENTITY suppression|nmod|accumulation blocks|nmod|suppression blocks|nsubj|END_ENTITY	Bcl-2 blocks cisplatin-induced apoptosis by suppression of ERK-mediated p53 accumulation in B104 cells .
11694525	0	p53	122,125	Bcl-2	99,104	p53	Bcl-2	7157	596	Gene	Gene	PaCa-2|compound|START_ENTITY ratio|nmod|PaCa-2 ratio|compound|END_ENTITY	Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2 / Bax ratio in the p53 mutant pancreatic_cancer cell line MIA PaCa-2 .
11802199	0	p53	113,116	Bcl-2	118,123	p53	Bcl-2	7157	596	Gene	Gene	expression|nmod|START_ENTITY using|dobj|expression patients|acl|using patients|dobj|END_ENTITY	Molecular staging of colorectal_cancer in African-American and Caucasian patients using phenotypic expression of p53 , Bcl-2 , MUC-1 AND p27 -LRB- kip-1 -RRB- .
12100521	0	p53	13,16	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	expression|compound|START_ENTITY iNOS|appos|expression disordered|nsubj|iNOS disordered|advmod|END_ENTITY	Bcl-2 , iNOS , p53 and PCNA expression in normal , disordered proliferative , hyperplastic and malignant endometrium .
12541691	0	p53	8,11	Bcl-2	1,6	p53	Bcl-2	7157	596	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	-LSB- Bcl-2 , p53 expression and Epstein-Barr_virus infection in primary nasopharyngeal_carcinoma -RSB- .
14518224	0	p53	96,99	Bcl-2	1,6	p53	Bcl-2	7157	596	Gene	Gene	-RSB-|compound|START_ENTITY import|nmod|-RSB- inhibitors|nmod|import inhibits|nmod|inhibitors inhibits|nsubj|END_ENTITY	-LSB- Bcl-2 inhibits p53-induced apoptosis after genotoxic damage by inhibitors of nuclear import of p53 -RSB- .
15390206	0	p53	12,15	Bcl-2	73,78	p53	Bcl-2	7157	596	Gene	Gene	Mutation|nmod|START_ENTITY correlates|nsubj|Mutation correlates|nmod|expression expression|compound|END_ENTITY	Mutation of p53 in head and neck_squamous_cell_carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis .
15647429	0	p53	16,19	Bcl-2	10,15	p53	Bcl-2	7157	596	Gene	Gene	ratio|compound|START_ENTITY ratio|dep|END_ENTITY	Increased Bcl-2 / p53 ratio in human osteoarthritic cartilage : a possible role in regulation of chondrocyte metabolism .
16297852	0	p53	149,152	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	role|nmod|START_ENTITY apoptosis|dep|role protected|nmod|apoptosis protected|nsubj|J J|amod|END_ENTITY	Bcl-2 but not clusterin/apolipoprotein J protected human diploid fibroblasts and immortalized keratinocytes from ceramide-induced apoptosis : role of p53 in the ceramide response .
16473926	0	p53	16,19	Bcl-2	21,26	p53	Bcl-2	7157	596	Gene	Gene	index|compound|START_ENTITY index|dep|END_ENTITY	Relationship of p53 , Bcl-2 , Ki-67 index and E-cadherin expression in early invasive breast_cancers with comedonecrosis as an accelerated apoptosis .
16916556	0	p53	45,48	Bcl-2	57,62	p53	Bcl-2	7157	596	Gene	Gene	mutant|compound|START_ENTITY mutant|appos|lymphoid_malignancy lymphoid_malignancy|compound|END_ENTITY	TRAIL enhances efficacy of radiotherapy in a p53 mutant , Bcl-2 overexpressing lymphoid_malignancy .
17187363	0	p53	4,7	Bcl-2	17,22	p53	Bcl-2	7157	596	Gene	Gene	phenotype|compound|START_ENTITY phenotype|compound|END_ENTITY	The p53 positive Bcl-2 negative phenotype is an independent marker of prognosis in breast_cancer .
17252199	0	p53	19,22	Bcl-2	33,38	p53	Bcl-2	7157	596	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|compound|END_ENTITY	Cytoplasmic mutant p53 increases Bcl-2 expression in estrogen_receptor-positive breast_cancer cells .
17332930	0	p53	90,93	Bcl-2	15,20	p53	Bcl-2	7157	596	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|members members|compound|END_ENTITY	Involvement of Bcl-2 family members , phosphatidylinositol 3 ' - kinase/AKT and mitochondrial p53 in curcumin -LRB- diferulolylmethane -RRB- - induced apoptosis in prostate_cancer .
17352211	0	p53	27,30	Bcl-2	63,68	p53	Bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	protein|appos|START_ENTITY apoptosis|nsubj|protein apoptosis|dobj|protein protein|appos|END_ENTITY	Tumour suppressor protein -LRB- p53 -RRB- , apoptosis inhibiting protein -LRB- Bcl-2 -RRB- and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expressions in a rat pancreatic tumour model .
17465228	0	p53	14,17	Bcl-2	20,25	p53	Bcl-2	7157	596	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|amod|END_ENTITY	Regulation of p53 - , Bcl-2 - and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells .
17536310	0	p53	20,23	Bcl-2	46,51	p53	Bcl-2	7157	596	Gene	Gene	Immunoreactivity|nmod|START_ENTITY Immunoreactivity|appos|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
18158619	0	p53	48,51	Bcl-2	15,20	p53	Bcl-2	7157	596	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast_cancer cells .
18828269	0	p53	58,61	Bcl-2	63,68	p53	Bcl-2	7157	596	Gene	Gene	Bcl-XL|compound|START_ENTITY Bcl-XL|dep|END_ENTITY	Apoptosis and adenocarcinoma_of_the_cardia : expression of p53 , Bcl-2 , Bcl-XL , WAF1 , and fas proteins and association with characteristics of the tumors .
19360319	0	p53	32,35	Bcl-2	42,47	p53	Bcl-2	7157	596	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
19555669	0	p53	99,102	Bcl-2	106,111	p53	Bcl-2	7157	596	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Transcriptional down-regulation of Bcl-2 by vinorelbine : identification of a novel binding site of p53 on Bcl-2 promoter .
19555669	0	p53	99,102	Bcl-2	35,40	p53	Bcl-2	7157	596	Gene	Gene	site|nmod|START_ENTITY identification|nmod|site down-regulation|dep|identification down-regulation|nmod|END_ENTITY	Transcriptional down-regulation of Bcl-2 by vinorelbine : identification of a novel binding site of p53 on Bcl-2 promoter .
21485723	0	p53	40,43	Bcl-2	28,33	p53	Bcl-2	7157	596	Gene	Gene	caspase-3|dep|START_ENTITY caspase-3|compound|END_ENTITY	Apoptosis and expression of Bcl-2 , Bax , p53 , caspase-3 , and Fas , Fas_ligand in placentas complicated by preeclampsia .
22178939	0	p53	50,53	Bcl-2	67,72	p53	Bcl-2	22060(Tax:10090)	12043(Tax:10090)	Gene	Gene	Bax|compound|START_ENTITY Bax|compound|END_ENTITY	Purple_sweet_potato pigments scavenge ROS , reduce p53 and modulate Bcl-2 / Bax to inhibit irradiation-induced apoptosis in murine thymocytes .
23316052	0	p53	153,156	Bcl-2	81,86	p53	Bcl-2	7157	596	Gene	Gene	pathways|compound|START_ENTITY mechanism|nmod|pathways reveal|dobj|mechanism reveal|nsubj|interactions interactions|nmod|domain domain|nmod|proteins proteins|compound|END_ENTITY	Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways .
23316052	0	p53	26,29	Bcl-2	81,86	p53	Bcl-2	7157	596	Gene	Gene	domain|compound|START_ENTITY domain|nmod|proteins proteins|compound|END_ENTITY	Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways .
24223706	0	p53	46,49	Bcl-2	25,30	p53	Bcl-2	7157	596	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Dihydromyricetin reduced Bcl-2 expression via p53 in human hepatoma HepG2 cells .
24342622	0	p53	13,16	Bcl-2	53,58	p53	Bcl-2	7157	596	Gene	Gene	peptide|compound|START_ENTITY Targeting|nmod|peptide analogues|nsubj|Targeting analogues|nmod|proteins proteins|compound|END_ENTITY	Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy .
24814047	0	p53	17,20	Bcl-2	60,65	p53	Bcl-2	7157	596	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|processing processing|acl|inhibit inhibit|dobj|END_ENTITY	Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage .
25404359	0	p53	21,24	Bcl-2	40,45	p53	Bcl-2	7157	596	Gene	Gene	Interacts|nsubj|START_ENTITY Interacts|nmod|END_ENTITY	Granzyme_B-Activated p53 Interacts with Bcl-2 To Promote Cytotoxic Lymphocyte-Mediated Apoptosis .
26303118	0	p53	86,89	Bcl-2	91,96	p53	Bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY cells|nmod|modulation mediates|dep|cells mediates|appos|expression expression|amod|END_ENTITY	Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53 , Bcl-2 , caspase-7 and caspase-3 protein expression .
26303118	0	p53	86,89	Bcl-2	91,96	p53	Bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY cells|nmod|modulation mediates|dep|cells mediates|appos|expression expression|amod|END_ENTITY	Fish oil administration mediates apoptosis of Walker 256 tumor cells by modulation of p53 , Bcl-2 , caspase-7 and caspase-3 protein expression .
26431162	0	p53	23,26	Bcl-2	92,97	p53	Bcl-2	7157	596	Gene	Gene	activation|compound|START_ENTITY effects|nmod|activation inhibition|nsubj|effects inhibition|nmod|inhibition inhibition|nmod|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
26819684	0	p53	105,108	Bcl-2	110,115	p53	Bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	Levels|dep|START_ENTITY Levels|dep|END_ENTITY	Neuroprotective Effect of Resveratrol on Acute Brain_Ischemia Reperfusion Injury by Measuring Annexin_V , p53 , Bcl-2 Levels in Rats .
27064014	0	p53	225,228	Bcl-2	201,206	p53	Bcl-2	7157	596	Gene	Gene	expression|compound|START_ENTITY levels|appos|expression levels|compound|END_ENTITY	Isololiolide , a carotenoid metabolite isolated from the brown_alga_Cystoseira_tamariscifolia , is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation , decreased Bcl-2 levels , increased p53 expression and PARP cleavage .
7734290	0	p53	59,62	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	correlated|nmod|START_ENTITY factor|acl|correlated protein|dep|factor protein|amod|END_ENTITY	Bcl-2 protein : a prognostic factor inversely correlated to p53 in non-small-cell_lung_cancer .
7768985	0	p53	84,87	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	containing|dobj|START_ENTITY protooncogene|dep|containing protooncogene|nsubj|END_ENTITY	Bcl-2 protooncogene expression in cervical_carcinoma cell lines containing inactive p53 .
8133533	0	p53	62,65	Bcl-2	4,9	p53	Bcl-2	7157	596	Gene	Gene	protein|compound|START_ENTITY related|nmod|protein indicator|acl|related protein|dep|indicator protein|compound|END_ENTITY	The Bcl-2 protein : a prognostic indicator strongly related to p53 protein in lymph node-negative breast_cancer patients .
8620501	0	p53	105,108	Bcl-2	124,129	p53	Bcl-2	7157	596	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Hypersensitivity of human testicular_tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax : Bcl-2 ratio .
8621251	0	p53	73,76	Bcl-2	23,28	p53	Bcl-2	7157	596	Gene	Gene	carrying|dobj|START_ENTITY expression|acl|carrying expression|nmod|END_ENTITY	Frequent expression of Bcl-2 in renal-cell_carcinomas carrying wild-type p53 .
8690754	0	p53	41,44	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene expression|amod|END_ENTITY	Bcl-2 expression and allelic loss of the p53 gene in gastric_carcinomas .
8959332	0	p53	14,17	Bcl-2	91,96	p53	Bcl-2	7157	596	Gene	Gene	Expression|nmod|START_ENTITY induces|nsubj|Expression induces|dobj|apoptosis apoptosis|acl:relcl|inhibited inhibited|nmod|END_ENTITY	Expression of p53 in Saos-2 osteosarcoma cells induces apoptosis which can be inhibited by Bcl-2 or the adenovirus E1B-55 kDa protein .
8982242	0	p53	69,72	Bcl-2	62,67	p53	Bcl-2	7157	596	Gene	Gene	oncoproteins|dep|START_ENTITY oncoproteins|dep|END_ENTITY	Detection of apoptotic cells and expression of Ki-67 antigen , Bcl-2 , p53 oncoproteins in human parathyroid_adenoma .
9108419	0	p53	67,70	Bcl-2	29,34	p53	Bcl-2	7157	596	Gene	Gene	status|compound|START_ENTITY correlate|nmod|status correlate|nsubj|Expression Expression|nmod|END_ENTITY	Expression and regulation of Bcl-2 , Bcl-xl , and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute_lymphoblastic_leukemia .
9413034	0	p53	89,92	Bcl-2	14,19	p53	Bcl-2	7157	596	Gene	Gene	accumulation|dep|START_ENTITY correlation|nmod|accumulation Expression|dep|correlation Expression|nmod|END_ENTITY	Expression of Bcl-2 in human breast_cancer : correlation between hormone receptor status , p53 protein accumulation and DNA strand breaks associated with apoptosis .
9419967	0	p53	15,18	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	import|compound|START_ENTITY inhibits|dobj|import inhibits|nsubj|END_ENTITY	Bcl-2 inhibits p53 nuclear import following DNA damage .
9614375	0	p53	68,71	Bcl-2	14,19	p53	Bcl-2	7157	596	Gene	Gene	comparison|nmod|START_ENTITY Expression|dep|comparison Expression|nmod|END_ENTITY	Expression of Bcl-2 in lung_neuroendocrine_tumours : comparison with p53 .
9667660	0	p53	43,46	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	association|nmod|START_ENTITY expression|dep|association expression|amod|END_ENTITY	Bcl-2 protein expression : association with p53 and prognosis in colorectal_cancer .
9754764	0	p53	141,144	Bcl-2	0,5	p53	Bcl-2	7157	596	Gene	Gene	expressing|dobj|START_ENTITY vagina|acl|expressing clear_cell_adenocarcinomas|nmod|vagina apoptosis|nmod|clear_cell_adenocarcinomas associated|nmod|apoptosis associated|nsubj|expression expression|amod|END_ENTITY	Bcl-2 protein expression associated with resistance to apoptosis in clear_cell_adenocarcinomas of the vagina and cervix expressing wild-type p53 .
9823951	0	p53	108,111	Bcl-2	137,142	p53	Bcl-2	7157	596	Gene	Gene	phenotype|compound|START_ENTITY phenotype|nmod|expression expression|compound|END_ENTITY	Sensitivity to Fas-mediated apoptosis in pediatric acute_lymphoblastic_leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression .
25225463	0	p53	48,51	Bcl2	53,57	p53	Bcl2	7157	596	Gene	Gene	epidermal|dep|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
15607964	0	p53	21,24	Bnip3L	0,6	p53	Bnip3L	7157	665	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Bnip3L is induced by p53 under hypoxia , and its knockdown promotes tumor growth .
26477313	0	p53	96,99	Braf	14,18	p53	Braf	22059(Tax:10090)	109880(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	TSH overcomes Braf -LRB- V600E -RRB- - induced senescence to promote tumor progression via downregulation of p53 expression in papillary_thyroid_cancer .
15532030	0	p53	40,43	Brn-3a	16,22	p53	Brn-3a	7157	5457	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Coexpression of Brn-3a POU protein with p53 in a population of neuronal progenitor cells is associated with differentiation and protection against apoptosis .
24319543	0	p53	21,24	C-6	0,3	p53	C-6	7157	729	Gene	Gene	Apoptosis|compound|START_ENTITY Apoptosis|compound|END_ENTITY	C-6 Ceramide Induces p53 Dependent Apoptosis in Human Astrocytoma Grade4 -LRB- Glioblastoma Multiforme -RRB- Cells .
8810134	0	p53	64,67	C-MYC	102,107	p53	C-MYC	7157	4609	Gene	Gene	mutation|compound|START_ENTITY mutation|nmod|gene gene|amod|END_ENTITY	Histological progression of follicular_lymphoma associated with p53 mutation and rearrangement of the C-MYC gene .
21566906	0	p53	20,23	C-erbb-2	135,143	p53	C-erbb-2	7157	2064	Gene	Gene	expression|compound|START_ENTITY value|nmod|expression value|amod|cathepsin-d cathepsin-d|amod|END_ENTITY	Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis , epidermal_growth-factor_receptor , C-erbb-2 , cathepsin-d , DNA-ploidy , parameters of cell-kinetics and conventional features .
7831152	0	p53	43,46	C-myc	33,38	p53	C-myc	7157	4609	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Mycosis fungoides : expression of C-myc p62 p53 , bcl-2 and PCNA proteins and absence of association with Epstein-Barr_virus .
18636078	0	p53	20,23	C/EBPbeta	0,9	p53	C/EBPbeta	22060(Tax:10090)	12608(Tax:10090)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	C/EBPbeta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19 -LRB- Arf -RRB- .
20020938	0	p53	43,46	CAS	0,3	p53	CAS	7157	1434	Gene	Gene	Accumulation|compound|START_ENTITY Accumulation|compound|END_ENTITY	CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis : Use of CAS for High-Sensitivity Anticancer Drug Screening .
14759370	0	p53	66,69	CBP	59,62	p53	CBP	7157	1387	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation .
15156194	0	p53	98,101	CBP	19,22	p53	CBP	7157	1387	Gene	Gene	inhibition|compound|START_ENTITY Utilization|nmod|inhibition Utilization|nmod|END_ENTITY	Utilization of the CBP but not the p300 co-activator by human_T-lymphotropic_virus_type-2 Tax for p53 inhibition .
15254196	0	p53	0,3	CBP	63,66	p53	CBP	7157	1387	Gene	Gene	targets|nsubj|START_ENTITY targets|nmod|END_ENTITY	p53 targets simian_virus_40 large T antigen for acetylation by CBP .
17434128	0	p53	104,107	CBP	19,22	p53	CBP	7157	1387	Gene	Gene	switching|nmod|START_ENTITY promotes|advcl|switching promotes|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
17434128	0	p53	104,107	CBP	95,98	p53	CBP	7157	1387	Gene	Gene	switching|nmod|START_ENTITY switching|dobj|preference preference|nmod|END_ENTITY	Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB .
19220000	0	p53	32,35	CBP	82,85	p53	CBP	7157	1387	Gene	Gene	domain|compound|START_ENTITY interactions|nmod|domain Mapping|dobj|interactions Mapping|nmod|domain domain|nmod|END_ENTITY	Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP .
19805293	0	p53	58,61	CBP	0,3	p53	CBP	7157	1387	Gene	Gene	ligases|nmod|START_ENTITY ligases|nsubj|END_ENTITY	CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53 .
20962272	0	p53	22,25	CBP	59,62	p53	CBP	7157	1387	Gene	Gene	enhancement|nmod|START_ENTITY binding|nsubj|enhancement binding|nmod|CREB-binding_protein CREB-binding_protein|appos|END_ENTITY	Graded enhancement of p53 binding to CREB-binding_protein -LRB- CBP -RRB- by multisite phosphorylation .
21220944	0	p53	63,66	CBP	30,33	p53	CBP	22060(Tax:10090)	12914(Tax:10090)	Gene	Gene	targets|nummod|START_ENTITY dispensable|nmod|targets dispensable|nsubjpass|END_ENTITY	Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways .
21271695	0	p53	100,103	CBP	80,83	p53	CBP	7157	1387	Gene	Gene	inhibitors|compound|START_ENTITY class|nmod|inhibitors design|dep|class design|nmod|modulators modulators|nmod|END_ENTITY	Rational design of cyclic peptide modulators of the transcriptional coactivator CBP : a new class of p53 inhibitors .
22198284	0	p53	0,3	CBP	66,69	p53	CBP	7157	1387	Gene	Gene	mutants|compound|START_ENTITY induce|nsubj|mutants induce|nmod|END_ENTITY	p53 mutants induce transcription of NF-kB2 in H1299 cells through CBP and STAT binding on the NF-kB2 promoter and gain of function activity .
22280219	0	p53	107,110	CBP	162,165	p53	CBP	7157	1387	Gene	Gene	subdomains|compound|START_ENTITY binding|nmod|subdomains binding|nmod|END_ENTITY	Quantitative analysis of multisite protein-ligand interactions by NMR : binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP .
9830059	0	p53	19,22	CBP	60,63	p53	CBP	7157	1387	Gene	Gene	Phosphorylation|nmod|START_ENTITY serine|nsubj|Phosphorylation serine|dobj|increases increases|acl|interaction interaction|nmod|END_ENTITY	Phosphorylation of p53 serine 15 increases interaction with CBP .
24492332	0	p53	30,33	CD10	18,22	p53	CD10	7157	4311	Gene	Gene	CD117|dep|START_ENTITY CD117|dep|END_ENTITY	Utility of Ki-67 , CD10 , CD34 , p53 , CD117 , and mast cell content in the differential diagnosis of cellular fibroadenomas and in the classification of phyllodes tumors of the breast .
17875988	0	p53	82,85	CD25	25,29	p53	CD25	22060(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY +|nmod|cells END_ENTITY|acl|+	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	p53	82,85	CD25	65,69	p53	CD25	22060(Tax:10090)	16184(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
11277413	0	p53	120,123	CD31	114,118	p53	CD31	7157	5175	Gene	Gene	Mib-1|dep|START_ENTITY Mib-1|compound|END_ENTITY	Oligodendroglioma : HMB-45 positivity using catalyzed signal amplification method : an immunohistochemical -LRB- HMB-45 , CD31 , p53 , Mib-1 -RRB- and ultrastructural study .
11781656	0	p53	30,33	CD34	103,107	p53	CD34	7157	947	Gene	Gene	therapy|compound|START_ENTITY purging|nmod|therapy vivo|acl|purging affect|nsubj|vivo affect|dobj|activity activity|nmod|cells cells|compound|END_ENTITY	Ex vivo purging by adenoviral p53 gene therapy does not affect NOD-SCID repopulating activity of human CD34 + cells .
12763212	0	p53	34,37	CD34	52,56	p53	CD34	7157	947	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
15319293	0	p53	154,157	CD34	69,73	p53	CD34	22060(Tax:10090)	947	Gene	Gene	mice|nmod|START_ENTITY Monitoring|dep|mice Monitoring|dobj|effect effect|nmod|gene gene|acl|silencing silencing|nmod|cells cells|compound|END_ENTITY	Monitoring the effect of gene silencing by RNA interference in human CD34 + cells injected into newborn RAG2 - / - gammac - / - mice : functional inactivation of p53 in developing T cells .
19922768	0	p53	79,82	CD34	39,43	p53	CD34	22060(Tax:10090)	12490(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY +|nmod|inhibition +|nsubj|generation generation|nmod|cells cells|nmod|END_ENTITY	Effective generation of iPS cells from CD34 + cord blood cells by inhibition of p53 .
21894749	0	p53	30,33	CD34	57,61	p53	CD34	7157	947	Gene	Gene	study|nmod|START_ENTITY study|nmod|cells cells|nummod|END_ENTITY	-LSB- Dynamic study of Bcl-2 , Bax , p53 , and ACE expression in CD34 + cells of peripheral blood and bone marrow in acute_leukemia patients in the course of induction chemotherapy -RSB- .
24492332	0	p53	30,33	CD34	24,28	p53	CD34	7157	947	Gene	Gene	CD117|dep|START_ENTITY CD117|dep|END_ENTITY	Utility of Ki-67 , CD10 , CD34 , p53 , CD117 , and mast cell content in the differential diagnosis of cellular fibroadenomas and in the classification of phyllodes tumors of the breast .
26431162	0	p53	23,26	CD34	112,116	p53	CD34	7157	947	Gene	Gene	activation|compound|START_ENTITY effects|nmod|activation inhibition|nsubj|effects inhibition|nmod|proliferating proliferating|compound|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
7786800	0	p53	105,108	CD34	62,66	p53	CD34	7157	947	Gene	Gene	treating|nmod|START_ENTITY treating|dobj|cells cells|nummod|END_ENTITY	Modulation of cell kinetics and cell cycle status by treating CD34 + chronic_myeloid_leukaemia cells with p53 antisense phosphorothioate oligonucleotides .
11958687	0	p53	18,21	CD4	64,67	p53	CD4	7157	920	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|nmod|T T|compound|END_ENTITY	Ability to induce p53 and caspase-mediated apoptosis in primary CD4 + T cells is variable among primary isolates of human_immunodeficiency_virus_type_1 .
17875988	0	p53	82,85	CD4	21,24	p53	CD4	22060(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY +|nmod|cells CD25|acl|+ CD25|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
17875988	0	p53	82,85	CD4	61,64	p53	CD4	22060(Tax:10090)	12504(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Nitric_oxide induces CD4 + CD25 + Foxp3 regulatory T cells from CD4 + CD25 T cells via p53 , IL-2 , and OX40 .
18245492	0	p53	72,75	CD4	37,40	p53	CD4	22060(Tax:10090)	12504(Tax:10090)	Gene	Gene	antigen|compound|START_ENTITY response|nmod|antigen response|compound|END_ENTITY	Self-tolerance does not restrict the CD4 + T-helper response against the p53 tumor antigen .
19184003	0	p53	63,66	CD4	0,3	p53	CD4	7157	920	Gene	Gene	peptides|compound|START_ENTITY HLA-DP5-restricted|dobj|peptides T|xcomp|HLA-DP5-restricted T|nsubj|+ +|compound|END_ENTITY	CD4 + T cell responses to HLA-DP5-restricted wild-type sequence p53 peptides in patients with head_and_neck_cancer .
21858191	0	p53	108,111	CD4	65,68	p53	CD4	7157	920	Gene	Gene	responses|nmod|START_ENTITY responses|dep|+ +|compound|END_ENTITY	Split T cell tolerance against a self/tumor antigen : spontaneous CD4 + but not CD8 + T cell responses against p53 in cancer patients and healthy donors .
24792911	0	p53	35,38	CD4	101,104	p53	CD4	7157	920	Gene	Gene	Downmodulation|nmod|START_ENTITY responses|nsubj|Downmodulation responses|amod|critical critical|nmod|T T|compound|END_ENTITY	Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4 -LRB- + -RRB- T cell responses .
7909159	0	p53	15,18	CD4	41,44	p53	CD4	22060(Tax:10090)	12504(Tax:10090)	Gene	Gene	product|compound|START_ENTITY recognized|nsubj|product recognized|nmod|+ +|compound|END_ENTITY	A mouse mutant p53 product recognized by CD4 + and CD8 + T cells .
8666950	0	p53	0,3	CD4	31,34	p53	CD4	22060(Tax:10090)	12504(Tax:10090)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|nmod|stage stage|compound|END_ENTITY	p53 prevents maturation to the CD4 + CD8 + stage of thymocyte differentiation in the absence of T cell receptor rearrangement .
9485210	0	p53	69,72	CD4	44,47	p53	CD4	7157	920	Gene	Gene	peptides|compound|START_ENTITY specific|nmod|peptides specific|compound|END_ENTITY	Evidence that HLA class II-restricted human CD4 + T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms .
9485210	0	p53	98,101	CD4	44,47	p53	CD4	7157	920	Gene	Gene	proteins|compound|START_ENTITY respond|nmod|proteins respond|nsubj|Evidence Evidence|acl:relcl|HLA HLA|dobj|specific specific|compound|END_ENTITY	Evidence that HLA class II-restricted human CD4 + T cells specific to p53 self peptides respond to p53 proteins of both wild and mutant forms .
19405121	0	p53	50,53	CD40	21,25	p53	CD40	22060(Tax:10090)	21939(Tax:10090)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	BCL6 cooperates with CD40 stimulation and loss of p53 function to rapidly transform primary B cells .
21947346	0	p53	17,20	CD43	73,77	p53	CD43	7157	6693	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|nmod|END_ENTITY	Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic_tumor cells .
20577877	0	p53	58,61	CD8	0,3	p53	CD8	7157	925	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	CD8 + T cell recognition of polymorphic wild-type sequence p53 -LRB- 65-73 -RRB- peptides in squamous_cell_carcinoma of the head_and_neck .
10027687	0	p53	30,33	CD95	49,53	p53	CD95	7157	355	Gene	Gene	/|nsubj|START_ENTITY /|dobj|END_ENTITY	Apoptosis-associated proteins p53 and APO-1 / Fas -LRB- CD95 -RRB- in brains of adult patients with Down syndrome .
10327065	0	p53	110,113	CD95	32,36	p53	CD95	7157	355	Gene	Gene	transfer|compound|START_ENTITY induced|nmod|transfer apoptosis|acl|induced receptor/ligand|nmod|apoptosis receptor/ligand|nsubj|involvement involvement|nmod|END_ENTITY	Differential involvement of the CD95 -LRB- Fas/APO -1 -RRB- receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells .
10951571	0	p53	15,18	CD95	61,65	p53	CD95	22060(Tax:10090)	14102(Tax:10090)	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Involvement of p53 and interleukin_3 in the up-regulation of CD95 -LRB- APO-1 / Fas -RRB- by X-ray irradiation .
12118319	0	p53	59,62	CD95	40,44	p53	CD95	22060(Tax:10090)	14102(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Tissue-specific regulation of Fas/APO -1 / CD95 expression by p53 .
12944915	0	p53	7,10	CD95	43,47	p53	CD95	7157	355	Gene	Gene	gain|compound|START_ENTITY gain|dep|repression repression|nmod|gene gene|compound|END_ENTITY	Mutant p53 gain of function : repression of CD95 -LRB- Fas/APO -1 -RRB- gene expression by tumor-associated p53 mutants .
12944915	0	p53	95,98	CD95	43,47	p53	CD95	7157	355	Gene	Gene	mutants|compound|START_ENTITY expression|nmod|mutants repression|acl|expression repression|nmod|gene gene|compound|END_ENTITY	Mutant p53 gain of function : repression of CD95 -LRB- Fas/APO -1 -RRB- gene expression by tumor-associated p53 mutants .
14612511	0	p53	8,11	CD95	65,69	p53	CD95	7157	355	Gene	Gene	Role|nmod|START_ENTITY Role|advcl|regulating regulating|dobj|expression expression|compound|END_ENTITY	Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells .
16611376	0	p53	50,53	CD95	67,71	p53	CD95	7157	355	Gene	Gene	apoptosis|nmod|START_ENTITY related|nmod|apoptosis related|nsubj|Fas Fas|appos|Apo-1 Apo-1|dep|END_ENTITY	In vitro folate_deficiency induces apoptosis by a p53 , Fas -LRB- Apo-1 , CD95 -RRB- independent , bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes .
9841917	0	p53	0,3	CD95	18,22	p53	CD95	7157	355	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|gene gene|compound|END_ENTITY	p53 activates the CD95 -LRB- APO-1 / Fas -RRB- gene in response to DNA damage by anticancer drugs .
17873905	0	p53	73,76	CDC20	0,5	p53	CDC20	7157	991	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	CDC20 , a potential cancer therapeutic target , is negatively regulated by p53 .
25860957	0	p53	80,83	CDK2	26,30	p53	CDK2	7157	1017	Gene	Gene	Independently|nmod|START_ENTITY Independently|compound|END_ENTITY	ING5 Is Phosphorylated by CDK2 and Controls Cell Proliferation Independently of p53 .
10465111	0	p53	34,37	CDK4	49,53	p53	CDK4	7157	1019	Gene	Gene	N-ras|nummod|START_ENTITY N-ras|nummod|END_ENTITY	Mutational analysis of the N-ras , p53 , p16INK4a , CDK4 , and MC1R genes in human congenital_melanocytic_naevi .
16552184	0	p53	20,23	CDK9	0,4	p53	CDK9	7157	1025	Gene	Gene	phosphorylates|iobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	CDK9 phosphorylates p53 on serine residues 33 , 315 and 392 .
26745862	0	p53	82,85	CDK9	128,132	p53	CDK9	7157	1025	Gene	Gene	Allows|dobj|START_ENTITY Allows|xcomp|Function Function|nmod|Inhibition Inhibition|compound|END_ENTITY	The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition .
24586177	0	p53	34,37	CEP-1	0,5	p53	CEP-1	7157	172616(Tax:6239)	Gene	Gene	homolog|compound|START_ENTITY END_ENTITY|appos|homolog	CEP-1 , the Caenorhabditis_elegans p53 homolog , mediates opposing longevity outcomes in mitochondrial electron transport chain mutants .
24586407	0	p53	17,20	CEP-1	11,16	p53	CEP-1	7157	172616(Tax:6239)	Gene	Gene	involved|nsubjpass|START_ENTITY END_ENTITY|parataxis|involved	C. _ elegans CEP-1 / p53 and BEC-1 are involved in DNA repair .
22032922	0	p53	21,24	CGB7	107,111	p53	CGB7	7157	94027	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|gene gene|amod|END_ENTITY	The tumor suppressor p53 induces expression of the pregnancy-supporting human chorionic gonadotropin -LRB- hCG -RRB- CGB7 gene .
11158294	0	p53	0,3	CHK1	19,23	p53	CHK1	7157	1111	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	p53 down-regulates CHK1 through p21 and the retinoblastoma protein .
15659650	0	p53	0,3	CHK1	34,38	p53	CHK1	7157	1111	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation .
19305158	0	p53	71,74	CHK1	44,48	p53	CHK1	7157	1111	Gene	Gene	checkpoints|compound|START_ENTITY effects|nmod|checkpoints Radiosensitization|dep|effects Radiosensitization|nmod|Chir-124 Chir-124|appos|inhibitor inhibitor|compound|END_ENTITY	Radiosensitization by Chir-124 , a selective CHK1 inhibitor : effects of p53 and cell cycle checkpoints .
19411857	0	p53	142,145	CHK1	44,48	p53	CHK1	7157	1111	Gene	Gene	effect|nmod|START_ENTITY carcinogens|nmod|effect END_ENTITY|nmod|carcinogens	Human_papilloma_virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53 .
20729914	0	p53	10,13	CHK1	65,69	p53	CHK1	7157	1111	Gene	Gene	Status|nmod|START_ENTITY predict|nsubj|Status predict|dobj|efficacy efficacy|nmod|inhibitors inhibitors|nummod|END_ENTITY	Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents .
26867682	0	p53	50,53	CHK1	0,4	p53	CHK1	7157	1111	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|expression expression|nummod|END_ENTITY	CHK1 expression in Gastric_Cancer is modulated by p53 and RB1/E2F1 : implications in chemo/radiotherapy response .
26921248	0	p53	50,53	CHK1	0,4	p53	CHK1	7157	1111	Gene	Gene	damage|nmod|START_ENTITY signaling|nmod|damage NF-kB|acl|signaling regulates|dobj|NF-kB regulates|nsubj|END_ENTITY	CHK1 regulates NF-kB signaling upon DNA damage in p53 - deficient cells and associated tumor-derived microvesicles .
11479205	0	p53	0,3	CHK2	93,97	p53	CHK2	7157	11200	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|END_ENTITY	p53 , CHK2 , and CHK1 genes in Finnish families with Li-Fraumeni_syndrome : further evidence of CHK2 in inherited cancer predisposition .
11948492	0	p53	67,70	CHK2	24,28	p53	CHK2	7157	11200	Gene	Gene	mutations|compound|START_ENTITY harboring|dobj|mutations gastric_carcinomas|acl|harboring expression|nmod|gastric_carcinomas expression|nmod|END_ENTITY	Increased expression of CHK2 in human gastric_carcinomas harboring p53 mutations .
12897801	0	p53	55,58	CHK2	27,31	p53	CHK2	7157	11200	Gene	Gene	domain|compound|START_ENTITY phosphorylation|nmod|domain phosphorylation|nummod|END_ENTITY	Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain .
17118344	0	p53	67,70	CHK2	40,44	p53	CHK2	7157	11200	Gene	Gene	status|compound|START_ENTITY related|nmod|status activation|acl|related activation|compound|END_ENTITY	Irofulven induces replication-dependent CHK2 activation related to p53 status .
22591041	0	p53	50,53	CK20	44,48	p53	CK20	7157	54474	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	Evaluation of Barrett 's _ esophagus with CK7 , CK20 , p53 , Ki67 , and COX2 expressions using chromoendoscopical examination .
9178172	0	p53	14,17	CK4	44,47	p53	CK4	7157	3851	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of p53 , Ki-67 and cytokeratin-4 -LRB- CK4 -RRB- in oral_papillomas .
22591041	0	p53	50,53	CK7	39,42	p53	CK7	7157	3855	Gene	Gene	Ki67|dep|START_ENTITY Ki67|compound|END_ENTITY	Evaluation of Barrett 's _ esophagus with CK7 , CK20 , p53 , Ki67 , and COX2 expressions using chromoendoscopical examination .
15103385	0	p53	62,65	COP1	21,25	p53	COP1	7157	64326	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The ubiquitin ligase COP1 is a critical negative regulator of p53 .
15280670	0	p53	4,7	COP1	21,25	p53	COP1	7157	64326	Gene	Gene	wagon|compound|START_ENTITY wagon|dep|found found|nsubjpass|END_ENTITY	The p53 paddy wagon : COP1 , Pirh2 and MDM2 are found resisting apoptosis and growth_arrest .
15492238	0	p53	32,35	COP1	0,4	p53	COP1	7157	64326	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	COP1 , the negative regulator of p53 , is overexpressed in breast and ovarian_adenocarcinomas .
15861129	0	p53	36,39	COP1	55,59	p53	COP1	7157	114769	Gene	Gene	regulates|dobj|START_ENTITY regulates|advcl|suppressing suppressing|dobj|END_ENTITY	Myeloid_leukemia_factor_1 regulates p53 by suppressing COP1 via COP9_signalosome_subunit_3 .
14500353	0	p53	105,108	COX-2	14,19	p53	COX-2	7157	4513	Gene	Gene	localization|nmod|START_ENTITY increases|dobj|localization increases|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of COX-2 in colon_cancer cell lines by celecoxib increases the nuclear localization of active p53 .
15707991	0	p53	16,19	COX-2	0,5	p53	COX-2	7157	5743	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis .
18617777	0	p53	55,58	COX-2	14,19	p53	COX-2	7157	5743	Gene	Gene	accumulation|nmod|START_ENTITY associated|nmod|accumulation associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of COX-2 is associated with accumulation of p53 in pancreatic_cancer : analysis of COX-2 and p53 expression in premalignant and malignant_ductal_pancreatic_lesions .
18617777	0	p53	55,58	COX-2	93,98	p53	COX-2	7157	5743	Gene	Gene	START_ENTITY|dep|analysis analysis|nmod|expression expression|compound|END_ENTITY	Expression of COX-2 is associated with accumulation of p53 in pancreatic_cancer : analysis of COX-2 and p53 expression in premalignant and malignant_ductal_pancreatic_lesions .
19082758	0	p53	0,3	COX-2	51,56	p53	COX-2	7157	4513	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|overexpression overexpression|nmod|_ _|amod|END_ENTITY	p53 and ATF-2 partly mediate the overexpression of COX-2 in H -LRB- 2 -RRB- O _ -LRB- 2 -RRB- - induced premature senescence of human fibroblasts .
19148359	0	p53	1,4	COX-2	12,17	p53	COX-2	7157	4513	Gene	Gene	START_ENTITY|appos|expression expression|compound|END_ENTITY	-LSB- p53 , p16 E COX-2 expression in esophageal_squamous_cell_carcinoma and histopathological association -RSB- .
21071999	0	p53	29,32	COX-2	63,68	p53	COX-2	7157	5743	Gene	Gene	transactivation|compound|START_ENTITY inhibitor|nmod|transactivation Pifithrin-a|appos|inhibitor up-regulates|nsubj|Pifithrin-a up-regulates|dobj|expression expression|compound|END_ENTITY	Pifithrin-a , an inhibitor of p53 transactivation , up-regulates COX-2 expression through an MAPK-dependent pathway .
22623379	0	p53	17,20	COX-2	90,95	p53	COX-2	301300(Tax:10116)	26198(Tax:10116)	Gene	Gene	Up-regulation|nmod|START_ENTITY signaling|nsubj|Up-regulation signaling|nmod|combination combination|nmod|inhibitor inhibitor|compound|END_ENTITY	Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor , Celecoxib and Dolastatin 15 , a marine mollusk linear peptide in experimental colon carcinogenesis .
23167625	0	p53	109,112	COX-2	10,15	p53	COX-2	7157	4513	Gene	Gene	independent|nmod|START_ENTITY decreases|xcomp|independent decreases|nsubj|inhibitor inhibitor|compound|END_ENTITY	Selective COX-2 inhibitor -LRB- celecoxib -RRB- decreases cellular growth in prostate_cancer cell lines independent of p53 .
23612655	0	p53	163,166	COX-2	11,16	p53	COX-2	7157	5743	Gene	Gene	gene|compound|START_ENTITY downregulation|nmod|gene associated|nmod|downregulation associated|nsubjpass|Changes Changes|nmod|factors factors|amod|END_ENTITY	Changes in COX-2 and oxidative damage factors during differentiation of human mesenchymal stem cells to hepatocyte-like cells is associated with downregulation of p53 gene .
26756900	0	p53	54,57	COX-2	0,5	p53	COX-2	7157	5743	Gene	Gene	accumulation|compound|START_ENTITY suppresses|dobj|accumulation suppresses|nsubj|NS-398 NS-398|compound|END_ENTITY	COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation .
22983008	0	p53	65,68	CREBZF	25,31	p53	CREBZF	7157	58487	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The transcription factor CREBZF is a novel positive regulator of p53 .
24200963	0	p53	163,166	CREBZF	65,71	p53	CREBZF	7157	58487	Gene	Gene	exerted|nmod|START_ENTITY exerted|nsubjpass|Effects Effects|appos|END_ENTITY	Effects of cyclic_AMP response element binding protein-Zhangfei -LRB- CREBZF -RRB- on the unfolded protein response and cell growth are exerted through the tumor suppressor p53 .
10473588	0	p53	11,14	CREB_binding_protein	36,56	p53	CREB binding protein	7157	1387	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of p53 to the KIX domain of CREB_binding_protein .
10848610	0	p53	0,3	CREB_binding_protein	19,39	p53	CREB binding protein	7157	1387	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	p53 recruitment of CREB_binding_protein mediated through phosphorylated CREB : a novel pathway of tumor suppressor regulation .
24019961	0	p53	16,19	CSF1	0,4	p53	CSF1	7157	1435	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest .
26158294	0	p53	0,3	CST5	34,38	p53	CST5	7157	1473	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	p53 directly activates cystatin_D / CST5 to mediate mesenchymal-epithelial_transition : a possible link to tumor suppression by vitamin_D .
19557330	0	p53	61,64	CXXC_finger_5_protein	4,25	p53	CXXC finger 5 protein	7157	51523	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	The CXXC_finger_5_protein is required for DNA damage-induced p53 activation .
17245118	0	p53	17,20	CYFIP2	0,6	p53	CYFIP2	7157	26999	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	CYFIP2 , a direct p53 target , is leptomycin-B sensitive .
22078465	0	p53	15,18	CYR61	0,5	p53	CYR61	7157	3491	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	CYR61 controls p53 and NF-kB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian_cancer cells .
11291926	0	p53	135,138	Caspase-3	0,9	p53	Caspase-3	7157	836	Gene	Gene	gene|compound|START_ENTITY carrying|dobj|gene downstream|xcomp|carrying downstream|nsubj|activation activation|amod|END_ENTITY	Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic_carcinoma cells carrying a mutant p53 gene .
16427076	0	p53	46,49	Caspase-3	0,9	p53	Caspase-3	7157	836	Gene	Gene	activity|nummod|START_ENTITY promotes|dobj|activity promotes|nsubj|cleavage cleavage|amod|END_ENTITY	Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity .
10210109	0	p53	13,16	Cathepsin_B	0,11	p53	Cathepsin B	7157	1508	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Cathepsin_B , p53 expression and AgNORs_in_transitional_cell_carcinoma .
9715268	0	p53	0,3	Cdc2	14,18	p53	Cdc2	7157	983	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p53 regulates Cdc2 independently of inhibitory phosphorylation to reinforce radiation-induced G2_arrest in human cells .
19273532	0	p53	19,22	Cdc20	37,42	p53	Cdc20	7157	991	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling .
21242964	0	p53	34,37	Cdc25B	0,6	p53	Cdc25B	7157	994	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors .
15574328	0	p53	59,62	Cdc25C	37,43	p53	Cdc25C	7157	995	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|downregulation downregulation|nmod|END_ENTITY	DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms : one involves direct binding to the cdc25C promoter .
20808790	0	p53	48,51	Cdk1	10,14	p53	Cdk1	7157	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cyclin_B1 / Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response .
12064478	0	p53	20,23	Cdk5	0,4	p53	Cdk5	301300(Tax:10116)	140908(Tax:10116)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cdk5 phosphorylates p53 and regulates its activity .
16021178	0	p53	0,3	Cdk5	51,55	p53	Cdk5	7157	1020	Gene	Gene	dispensable|nsubj|START_ENTITY dispensable|nmod|activation activation|amod|END_ENTITY	p53 , Apaf-1 , caspase-3 , _ and _ -9 are dispensable for Cdk5 activation during cell death .
17591690	0	p53	32,35	Cdk5	47,51	p53	Cdk5	7157	1020	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death .
20673369	0	p53	52,55	Cdk5	0,4	p53	Cdk5	7157	1020	Gene	Gene	inhibition|compound|START_ENTITY overexpressed|dobj|inhibition overexpressed|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression .
16741955	0	p53	20,23	Cdk9	0,4	p53	Cdk9	7157	1025	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cdk9 phosphorylates p53 on serine 392 independently of CKII .
17942552	0	p53	117,120	Cdk9	64,68	p53	Cdk9	7157	1025	Gene	Gene	suppressor|compound|START_ENTITY phosphorylation|nmod|suppressor phosphorylation|amod|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor .
17157788	0	p53	60,63	Che-1	0,5	p53	Che-1	7157	26574	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint .
17189183	0	p53	81,84	Che-1	68,73	p53	Che-1	7157	26574	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	DNA damage signaling recruits the RNA polymerase II binding protein Che-1 to the p53 promoter .
20708154	0	p53	56,59	Che-1	0,5	p53	Che-1	7157	26574	Gene	Gene	transcription|compound|START_ENTITY sustaining|dobj|transcription promotes|advcl|sustaining promotes|nsubj|END_ENTITY	Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation .
27012205	0	p53	78,81	Che-1	0,5	p53	Che-1	7157	26574	Gene	Gene	expression|compound|START_ENTITY inhibiting|dobj|expression induces|advcl|inhibiting induces|nsubj|silencing silencing|amod|END_ENTITY	Che-1 gene silencing induces osteosarcoma cell apoptosis by inhibiting mutant p53 expression .
10673501	0	p53	76,79	Chk1	41,45	p53	Chk1	7157	1111	Gene	Gene	phosphorylate|dobj|START_ENTITY phosphorylate|nsubj|homologs homologs|nmod|END_ENTITY	The human homologs of checkpoint kinases Chk1 and Cds1 -LRB- Chk2 -RRB- phosphorylate p53 at multiple DNA damage-inducible sites .
11599922	0	p53	49,52	Chk1	30,34	p53	Chk1	22060(Tax:10090)	12649(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Tissue-specific regulation of Chk1 expression by p53 .
16511572	0	p53	84,87	Chk1	65,69	p53	Chk1	7157	1111	Gene	Gene	activation|compound|START_ENTITY resulting|nmod|activation phosphorylated|xcomp|resulting phosphorylated|nmod|END_ENTITY	14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1 , resulting in p53 activation .
18281511	0	p53	10,13	Chk1	129,133	p53	Chk1	7157	1111	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|induction induction|acl|rendering rendering|xcomp|sensitive sensitive|nmod|inhibitors inhibitors|amod|END_ENTITY	Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest .
18281511	0	p53	27,30	Chk1	129,133	p53	Chk1	7157	1111	Gene	Gene	tumors|nummod|START_ENTITY signaling|nmod|tumors p53|acl|signaling attenuates|nsubj|p53 attenuates|dobj|induction induction|acl|rendering rendering|xcomp|sensitive sensitive|nmod|inhibitors inhibitors|amod|END_ENTITY	Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest .
18510930	0	p53	75,78	Chk1	0,4	p53	Chk1	7157	1111	Gene	Gene	bypasses|dobj|START_ENTITY damage|acl:relcl|bypasses suppresses|nmod|damage suppresses|nsubj|END_ENTITY	Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53 , Bcl-2 , and caspase-3 .
18642443	0	p53	26,29	Chk1	0,4	p53	Chk1	7157	1111	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|inhibition inhibition|amod|END_ENTITY	Chk1 inhibition activates p53 through p38_MAPK in tetraploid_cancer cells .
22134241	0	p53	32,35	Chk1	93,97	p53	Chk1	7157	1111	Gene	Gene	cells|nummod|START_ENTITY radiosensitization|nmod|cells Selective|dobj|radiosensitization Selective|nmod|inhibition inhibition|nmod|END_ENTITY	Selective radiosensitization of p53 mutant pancreatic_cancer cells by combined inhibition of Chk1 and PARP1 .
22430210	0	p53	53,56	Chk1	23,27	p53	Chk1	7157	1111	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|lethality lethality|nmod|inhibition inhibition|amod|END_ENTITY	Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells .
22825736	0	p53	38,41	Chk1	4,8	p53	Chk1	7157	1111	Gene	Gene	cells|nummod|START_ENTITY sensitises|dobj|cells sensitises|nsubj|AZD7762 AZD7762|amod|END_ENTITY	The Chk1 inhibitor AZD7762 sensitises p53 mutant breast_cancer cells to radiation in vitro and in vivo .
10531348	0	p53	80,83	Chk2	20,24	p53	Chk2	7157	11200	Gene	Gene	kinase|nmod|START_ENTITY kinase|nsubj|Role Role|appos|END_ENTITY	Role of human Cds1 -LRB- Chk2 -RRB- kinase in DNA damage checkpoint and its regulation by p53 .
10673501	0	p53	76,79	Chk2	56,60	p53	Chk2	7157	11200	Gene	Gene	phosphorylate|dobj|START_ENTITY phosphorylate|nsubj|homologs homologs|nmod|Chk1 Chk1|appos|END_ENTITY	The human homologs of checkpoint kinases Chk1 and Cds1 -LRB- Chk2 -RRB- phosphorylate p53 at multiple DNA damage-inducible sites .
10710310	0	p53	33,36	Chk2	62,66	p53	Chk2	22060(Tax:10090)	50883(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY damage-induced|dobj|activation damage-induced|nmod|END_ENTITY	DNA damage-induced activation of p53 by the checkpoint kinase Chk2 .
12654917	0	p53	46,49	Chk2	4,8	p53	Chk2	7157	11200	Gene	Gene	responses|compound|START_ENTITY required|nmod|responses required|nsubjpass|suppressor suppressor|amod|END_ENTITY	The Chk2 tumor suppressor is not required for p53 responses in human cancer cells .
15044452	0	p53	42,45	Chk2	23,27	p53	Chk2	7157	11200	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y .
22312557	0	p53	22,25	Chk2	117,121	p53	Chk2	7157	11200	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|Inhibitor Inhibitor|compound|END_ENTITY	The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor .
22312557	0	p53	22,25	Chk2	47,51	p53	Chk2	7157	11200	Gene	Gene	START_ENTITY|nmod|Phosphorylation Phosphorylation|compound|END_ENTITY	The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor .
12411481	0	p53	44,47	Cox-2	26,31	p53	Cox-2	7157	5743	Gene	Gene	apoptosis|amod|START_ENTITY counteracts|dobj|apoptosis counteracts|nsubj|induction induction|nmod|END_ENTITY	P53-mediated induction of Cox-2 counteracts p53 - or genotoxic stress-induced apoptosis .
20808790	0	p53	48,51	Cyclin_B1	0,9	p53	Cyclin B1	7157	891	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|nsubj|phosphorylation END_ENTITY|parataxis|induces	Cyclin_B1 / Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response .
10376986	0	p53	82,85	Cyclin_D1	0,9	p53	Cyclin D1	7157	595	Gene	Gene	expression|compound|START_ENTITY association|nmod|expression expression|dep|association expression|amod|END_ENTITY	Cyclin_D1 expression in non-small-cell_lung_cancers : its association with altered p53 expression , cell proliferation and clinical outcome .
10766394	0	p53	106,109	Cyclin_D1	0,9	p53	Cyclin D1	7157	595	Gene	Gene	expression|compound|START_ENTITY relevance|nmod|expression expression|dep|relevance expression|amod|END_ENTITY	Cyclin_D1 expression in oral_squamous_cell_carcinomas : clinicopathological relevance and correlation with p53 expression .
11161387	0	p53	85,88	Cyclin_D1	0,9	p53	Cyclin D1	7157	595	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|amod|END_ENTITY	Cyclin_D1 expression in transitional_cell_carcinoma of the bladder : correlation with p53 , waf1 , pRb and Ki67 .
24213463	0	p53	35,38	Cyclin_D1	40,49	p53	Cyclin D1	7157	595	Gene	Gene	Ki67|compound|START_ENTITY Ki67|dep|END_ENTITY	Automated Quantitative Analysis of p53 , Cyclin_D1 , Ki67 and pERK Expression in Breast_Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics .
8552389	0	p53	44,47	Cyclin_D1	0,9	p53	Cyclin D1	22060(Tax:10090)	12443(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY involved|nmod|suppression involved|nsubj|END_ENTITY	Cyclin_D1 and p21/waf1 are both involved in p53 growth suppression .
7957050	0	p53	44,47	Cyclin_G	0,8	p53	Cyclin G	22060(Tax:10090)	12450(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY target|nmod|protein target|nsubj|END_ENTITY	Cyclin_G is a transcriptional target of the p53 tumor suppressor protein .
11756433	0	p53	156,159	Cyclooxygenase-2	0,16	p53	Cyclooxygenase-2	22060(Tax:10090)	19225(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY proliferation|nmod|induction inhibitors|nsubj|proliferation growth|acl:relcl|inhibitors inhibits|dobj|growth inhibits|nsubj|overexpression overexpression|amod|END_ENTITY	Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1 / cip-1 and p27kip-1 .
15550400	0	p53	109,112	Cyclooxygenase-2	0,16	p53	Cyclooxygenase-2	7157	5743	Gene	Gene	activity|compound|START_ENTITY apoptosis|nmod|activity suppresses|dobj|apoptosis suppresses|nsubj|END_ENTITY	Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate_cancer cell line .
15608668	0	p53	32,35	Cyclooxygenase-2	0,16	p53	Cyclooxygenase-2	7157	5743	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis .
16865247	0	p53	102,105	Cyclooxygenase-2	0,16	p53	Cyclooxygenase-2	7157	5743	Gene	Gene	outcome|compound|START_ENTITY association|nmod|outcome expression|dep|association expression|amod|END_ENTITY	Cyclooxygenase-2 expression in squamous_cell_carcinoma_of_the_oral_cavity and pharynx : association to p53 and clinical outcome .
19465063	0	p53	42,45	Cyclooxygenase-2	0,16	p53	Cyclooxygenase-2	7157	5743	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53 .
19465063	0	p53	82,85	Cyclooxygenase-2	0,16	p53	Cyclooxygenase-2	7157	5743	Gene	Gene	interaction|nmod|START_ENTITY inactivates|nmod|interaction inactivates|nsubj|END_ENTITY	Cyclooxygenase-2 functionally inactivates p53 through a physical interaction with p53 .
25454946	0	p53	7,10	DAB2IP	98,104	p53	DAB2IP	7157	153090	Gene	Gene	Reprograms|nsubj|START_ENTITY Reprograms|nmod|Interaction Interaction|nmod|END_ENTITY	Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP .
25583813	0	p53	7,10	DAB2IP	56,62	p53	DAB2IP	7157	153090	Gene	Gene	Modulates|nsubj|START_ENTITY Modulates|nmod|END_ENTITY	Mutant p53 Modulates TNF Signaling via Interaction with DAB2IP .
25659035	0	p53	54,57	DAXX	48,52	p53	DAXX	7157	1616	Gene	Gene	kinase|dep|START_ENTITY kinase|compound|END_ENTITY	DNA damage-induced regulatory interplay between DAXX , p53 , ATM kinase and Wip1 phosphatase .
12628922	0	p53	0,3	DDR1	32,36	p53	DDR1	7157	780	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop .
15703819	0	p53	14,17	DJ-1	0,4	p53	DJ-1	7157	11315	Gene	Gene	activity|compound|START_ENTITY inhibited|nsubj|activity restores|ccomp|inhibited restores|nsubj|END_ENTITY	DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3 .
18042550	0	p53	49,52	DJ-1	0,4	p53	DJ-1	7157	11315	Gene	Gene	activity|nummod|START_ENTITY repressing|dobj|activity decreases|advcl|repressing decreases|nsubj|END_ENTITY	DJ-1 decreases Bax expression through repressing p53 transcriptional activity .
18339323	0	p53	44,47	DJ-1	28,32	p53	DJ-1	7157	11315	Gene	Gene	activity|nummod|START_ENTITY repress|dobj|activity critical|xcomp|repress critical|nmod|END_ENTITY	Sumoylation is critical for DJ-1 to repress p53 transcriptional activity .
20497343	0	p53	65,68	DJ-1	0,4	p53	DJ-1	7157	11315	Gene	Gene	expression|compound|START_ENTITY correlation|nmod|expression shows|dobj|correlation shows|nsubj|expression expression|compound|END_ENTITY	DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal_growth_factor_receptor amplification .
21725356	0	p53	44,47	DJ-1	16,20	p53	DJ-1	7157	11315	Gene	Gene	loss|compound|START_ENTITY upregulation|nmod|loss upregulation|compound|END_ENTITY	Consequences of DJ-1 upregulation following p53 loss and cell transformation .
23149933	0	p53	23,26	DJ-1	9,13	p53	DJ-1	7157	11315	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner .
23149933	0	p53	43,46	DJ-1	9,13	p53	DJ-1	7157	11315	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner .
23418303	0	p53	121,124	DJ-1	38,42	p53	DJ-1	7157	11315	Gene	Gene	counteracts|dobj|START_ENTITY counteracts|nsubj|END_ENTITY	The Parkinson_disease-related protein DJ-1 counteracts mitochondrial impairment_induced_by_the_tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering .
14764457	0	p53	0,3	DMC1	89,93	p53	DMC1	7157	11144	Gene	Gene	Protein|compound|START_ENTITY interacts|nsubj|Protein interacts|nmod|END_ENTITY	p53 Protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis .
20204287	0	p53	102,105	DNA-dependent_protein_kinase	120,148	p53	DNA-dependent protein kinase	7157	5591	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Radiosensitivity profiles from a panel of ovarian_cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent_protein_kinase activities .
25146923	0	p53	75,78	DNAJB9	29,35	p53	DNAJB9	7157	4189	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Genotoxic stress/p53-induced DNAJB9 inhibits the pro-apoptotic function of p53 .
23431054	0	p53	16,19	DNMT1	0,5	p53	DNMT1	7157	1786	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis .
20101238	0	p53	61,64	DREF	8,12	p53	DREF	2768677(Tax:7227)	34328(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of DREF in transcriptional regulation of the Drosophila p53 gene .
21364582	0	p53	32,35	DSC3	0,4	p53	DSC3	7157	1825	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	DSC3 expression is regulated by p53 , and methylation of DSC3 DNA is a prognostic marker in human colorectal_cancer .
18403641	0	p53	23,26	DUSP1	0,5	p53	DUSP1	7157	1843	Gene	Gene	controlled|nmod|START_ENTITY controlled|nsubjpass|END_ENTITY	DUSP1 is controlled by p53 during the cellular response to oxidative stress .
23108049	0	p53	43,46	DUSP6	0,5	p53	DUSP6	7157	1848	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins .
21637297	0	p53	0,3	DYRK1A	43,49	p53	DYRK1A	7157	1859	Gene	Gene	downregulates|compound|START_ENTITY syndrome-associated|nsubj|downregulates syndrome-associated|dobj|END_ENTITY	p53 downregulates Down syndrome-associated DYRK1A through miR-1246 .
17349958	0	p53	46,49	DYRK2	0,5	p53	DYRK2	7157	8445	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage .
15364927	0	p53	23,26	Daxx	40,44	p53	Daxx	7157	1616	Gene	Gene	functions|compound|START_ENTITY regulation|nmod|functions regulation|nmod|END_ENTITY	Negative regulation of p53 functions by Daxx and the involvement of MDM2 .
16230375	0	p53	29,32	Decoy_receptor_2	0,16	p53	Decoy receptor 2	7157	8793	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Decoy_receptor_2 -LRB- DcR2 -RRB- is a p53 target gene and regulates chemosensitivity .
24220032	0	p53	7,10	Dicer	21,26	p53	Dicer	7157	23405	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Mutant p53 regulates Dicer through p63-dependent and - independent mechanisms to promote an invasive phenotype .
24979267	0	p53	22,25	Dicer	0,5	p53	Dicer	22060(Tax:10090)	23405	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Dicer cooperates with p53 to suppress DNA damage and skin_carcinogenesis in mice .
10777218	0	p53	69,72	Dickkopf-1	0,10	p53	Dickkopf-1	7157	22943	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Dickkopf-1 , an inhibitor of the Wnt signaling pathway , is induced by p53 .
26971015	0	p53	69,72	Drosha	76,82	p53	Drosha	7157	29102	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Dysregulation of microRNA biogenesis in cancer : the impact of mutant p53 on Drosha complex activity .
24758576	0	p53	16,19	Drp1	0,4	p53	Drp1	301300(Tax:10116)	114114(Tax:10116)	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Drp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivo .
20696760	0	p53	22,25	Dyrk1A	0,6	p53	Dyrk1A	7157	1859	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells .
10385363	0	p53	103,106	E-cadherin	108,118	p53	E-cadherin	7157	999	Gene	Gene	epidermal_growth_factor_receptor|compound|START_ENTITY epidermal_growth_factor_receptor|dep|END_ENTITY	Evaluation of malignancy and the prognosis of esophageal_cancer based on an immunohistochemical study -LRB- p53 , E-cadherin , epidermal_growth_factor_receptor -RRB- .
11665847	0	p53	79,82	E-cadherin	8,18	p53	E-cadherin	7157	999	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Loss of E-cadherin expression in gastric_intestinal_metaplasia and later stage p53 altered expression in gastric_carcinogenesis .
19507255	0	p53	45,48	E-cadherin	175,185	p53	E-cadherin	7157	999	Gene	Gene	interference|compound|START_ENTITY effective|nmod|interference effective|advcl|inducing inducing|dobj|disorganization disorganization|dep|role role|nmod|END_ENTITY	DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells : role of E-cadherin .
19507255	0	p53	9,12	E-cadherin	175,185	p53	E-cadherin	7157	999	Gene	Gene	mutation|compound|START_ENTITY effective|nsubj|mutation effective|advcl|inducing inducing|dobj|disorganization disorganization|dep|role role|nmod|END_ENTITY	DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells : role of E-cadherin .
20332115	0	p53	30,33	E-cadherin	52,62	p53	E-cadherin	7157	999	Gene	Gene	mutants|compound|START_ENTITY function|nmod|mutants Gain|nmod|function regulates|nsubj|Gain regulates|dobj|expression expression|amod|END_ENTITY	Gain of oncogenic function of p53 mutants regulates E-cadherin expression uncoupled from cell invasion in colon_cancer cells .
20972462	0	p53	14,17	E-cadherin	125,135	p53	E-cadherin	7157	999	Gene	Gene	Inhibition|nmod|START_ENTITY induces|nsubj|Inhibition induces|advcl|accentuating accentuating|dobj|suppression suppression|nmod|END_ENTITY	Inhibition of p53 induces invasion of serous_borderline_ovarian_tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin .
21478913	0	p53	14,17	E-cadherin	28,38	p53	E-cadherin	7157	999	Gene	Gene	Inhibition|nmod|START_ENTITY represses|nsubj|Inhibition represses|dobj|expression expression|amod|END_ENTITY	Inhibition of p53 represses E-cadherin expression by increasing DNA_methyltransferase-1 and promoter methylation in serous borderline ovarian_tumor cells .
21493295	0	p53	71,74	E-cadherin	59,69	p53	E-cadherin	7157	999	Gene	Gene	p16|dep|START_ENTITY p16|dep|END_ENTITY	Loss of heterozygosity of tumor suppressor genes -LRB- p16 , Rb , E-cadherin , p53 -RRB- in hypopharynx_squamous_cell_carcinoma .
21528083	0	p53	33,36	E-cadherin	21,31	p53	E-cadherin	7157	999	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
9463572	0	p53	49,52	E-cadherin	14,24	p53	E-cadherin	7157	999	Gene	Gene	status|compound|START_ENTITY Expression|nmod|status Expression|nmod|END_ENTITY	Expression of E-cadherin and its relation to the p53 protein status in human breast_carcinomas .
9467960	0	p53	62,65	E1B	10,13	p53	E1B	7157	6080	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus_infected cells .
15907477	0	p53	56,59	E1B-AP5	43,50	p53	E1B-AP5	7157	11100	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of the hnRNP family member E1B-AP5 with p53 .
22480684	0	p53	63,66	E2F-1	19,24	p53	E2F-1	7157	1869	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response .
10766769	0	p53	85,88	E2F1	0,4	p53	E2F1	7157	1869	Gene	Gene	independent|nmod|START_ENTITY mediates|nmod|independent mediates|nsubj|END_ENTITY	E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase_3 .
12080472	0	p53	19,22	E2F1	31,35	p53	E2F1	22060(Tax:10090)	13555(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY induces|nsubj|inhibition induces|dobj|transactivation transactivation|nummod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
12101227	0	p53	32,35	E2F1	0,4	p53	E2F1	22060(Tax:10090)	13555(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis .
12101227	0	p53	60,63	E2F1	0,4	p53	E2F1	22060(Tax:10090)	13555(Tax:10090)	Gene	Gene	accumulation|compound|START_ENTITY coincident|nmod|accumulation phosphorylation|acl:relcl|coincident induces|dobj|phosphorylation induces|nsubj|END_ENTITY	E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis .
12625370	0	p53	25,28	E2F1	0,4	p53	E2F1	7157	1869	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	E2F1 activates the human p53 promoter and overcomes the repressive effect of hepatitis_B viral X protein -LRB- Hbx -RRB- on the p53 promoter .
15140942	0	p53	46,49	E2F1	0,4	p53	E2F1	7157	1869	Gene	Gene	phosphorylation|compound|START_ENTITY induce|dobj|phosphorylation signaling|xcomp|induce ATM|acl|signaling uses|dobj|ATM uses|nsubj|END_ENTITY	E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis .
16037820	0	p53	82,85	E2F1	49,53	p53	E2F1	7157	1869	Gene	Gene	phosphorylation|nmod|START_ENTITY requires|dobj|phosphorylation requires|nsubj|retention retention|nmod|p53 p53|nmod|END_ENTITY	Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315 .
17146434	0	p53	109,112	E2F1	127,131	p53	E2F1	7157	1869	Gene	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells enhances|dobj|apoptosis enhances|advcl|activating activating|dobj|END_ENTITY	Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1 .
17690688	0	p53	67,70	E2F1	85,89	p53	E2F1	7157	1869	Gene	Gene	target|nmod|START_ENTITY target|acl:relcl|inhibits inhibits|dobj|END_ENTITY	The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1 .
19783986	0	p53	49,52	E2F1	54,58	p53	E2F1	7157	1869	Gene	Gene	axis|dobj|START_ENTITY promotes|ccomp|axis promotes|nsubj|END_ENTITY	The execution of the transcriptional axis mutant p53 , E2F1 and ID4 promotes tumor neo-angiogenesis .
20805247	0	p53	49,52	E2F1	28,32	p53	E2F1	7157	1869	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|transactivation transactivation|nmod|END_ENTITY	MEF/ELF4 transactivation by E2F1 is inhibited by p53 .
20952509	0	p53	74,77	E2F1	86,90	p53	E2F1	7157	1869	Gene	Gene	expressing|dobj|START_ENTITY expressing|nmod|upregulation upregulation|compound|END_ENTITY	Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation .
21656380	0	p53	70,73	E2F1	50,54	p53	E2F1	7157	1869	Gene	Gene	status|compound|START_ENTITY independent|nmod|status independent|nsubj|END_ENTITY	MiR-106a inhibits glioma cell growth by targeting E2F1 independent of p53 status .
23954287	0	p53	15,18	E2F1	0,4	p53	E2F1	7157	1869	Gene	Gene	transcription|compound|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	E2F1 activates p53 transcription through its distal site and participates in apoptosis induction in HPV-positive cells .
9671769	0	p53	85,88	E2F1	10,14	p53	E2F1	22060(Tax:10090)	13555(Tax:10090)	Gene	Gene	heterozygous|nmod|START_ENTITY induces|ccomp|heterozygous induces|nsubj|activity activity|compound|END_ENTITY	Increased E2F1 activity induces skin_tumors in mice heterozygous and nullizygous for p53 .
24285179	0	p53	19,22	EEF1A2	0,6	p53	EEF1A2	7157	1917	Gene	Gene	inactivates|dobj|START_ENTITY inactivates|nsubj|END_ENTITY	EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular_carcinoma .
25394965	0	p53	21,24	EEF1A2	1,7	p53	EEF1A2	7157	1917	Gene	Gene	function|compound|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	-LSB- EEF1A2 inhibits the p53 function in hepatocellular_carcinoma via PI3K/AKT/mTOR-dependent stabilization of MDM4 -RSB- .
10764044	0	p53	33,36	EGFR	74,78	p53	EGFR	7157	1956	Gene	Gene	tumor|compound|START_ENTITY inactivation|nmod|tumor suppressor|nsubj|inactivation suppressor|dobj|pathway pathway|nmod|distinguish distinguish|amod|END_ENTITY	Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult_astrocytomas .
10870681	0	p53	165,168	EGFR	114,118	p53	EGFR	7157	1956	Gene	Gene	oncogene|iobj|START_ENTITY oncogene|nsubj|analysis analysis|nmod|expression expression|appos|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
16986486	0	p53	71,74	EGFR	76,80	p53	EGFR	7157	1956	Gene	Gene	ret-oncogene|compound|START_ENTITY ret-oncogene|dep|END_ENTITY	-LSB- Prognostic value of the expression of thyreoglobulin and oncomarkers -LRB- p53 , EGFR , ret-oncogene -RRB- in different types of papillary_carcinoma_of_the_thyroid : clinicomorphological and immunohistochemical studies -RSB- .
19360319	0	p53	32,35	EGFR	126,130	p53	EGFR	7157	1956	Gene	Gene	Expression|appos|START_ENTITY Expression|appos|Bcl-2 Bcl-2|nmod|sample sample|nmod|non-small_cell_lung_cancer non-small_cell_lung_cancer|acl|bearing bearing|dobj|deletion deletion|nmod|gene gene|amod|END_ENTITY	Expression of ABC transporters , p53 , Bax , Bcl-2 in an archival sample of non-small_cell_lung_cancer bearing a deletion in the EGFR gene .
21290211	0	p53	78,81	EGFR	72,76	p53	EGFR	7157	1956	Gene	Gene	mutations|amod|START_ENTITY mutations|amod|END_ENTITY	Establishment and characterization of six human lung_cancer cell lines : EGFR , p53 gene mutations and expressions of drug sensitivity genes .
21388911	0	p53	66,69	EGFR	34,38	p53	EGFR	7157	1956	Gene	Gene	accumulation|compound|START_ENTITY correlates|nmod|accumulation abundance|dobj|correlates abundance|nsubj|Epidermal_growth_factor_receptor Epidermal_growth_factor_receptor|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- abundance correlates with p53 and Bcl-2 accumulation and patient age in a small cohort of North African nasopharyngeal_carcinoma patients .
22068033	0	p53	0,3	EGFR	37,41	p53	EGFR	7157	1956	Gene	Gene	modulates|compound|START_ENTITY acquired|nsubj|modulates acquired|nmod|inhibitors inhibitors|amod|END_ENTITY	p53 modulates acquired resistance to EGFR inhibitors and radiation .
22286119	4	p53	881,884	EGFR	886,890	CK7	CK20	3855	54474	Gene	Gene	CDX2|dep|START_ENTITY CDX2|dep|END_ENTITY	METHODS AND RESULTS : We immunohistochemically examined the CK7/CK20 patterns , mucin expression profiles -LRB- MUC5AC , MUC6 , MUC2 and CD10 -RRB- , and the cancer-related molecules -LRB- CDX2 , p53 , EGFR and b-catenin -RRB- , using a tissue microarray with 870 GCs .
23872073	0	p53	70,73	EGFR	53,57	p53	EGFR	7157	1956	Gene	Gene	species|compound|START_ENTITY species|amod|END_ENTITY	Induction of renal fibrotic genes by TGF-b1 requires EGFR activation , p53 and reactive oxygen species .
24021343	0	p53	10,13	EGFR	15,19	p53	EGFR	7157	1956	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	p16INK4A , p53 , EGFR expression and KRAS mutation status in squamous_cell_cancers of the anus : correlation with outcomes following chemo-radiotherapy .
24927258	0	p53	120,123	EGFR	153,157	p53	EGFR	7157	1956	Gene	Gene	deficiency|compound|START_ENTITY functional|dobj|deficiency functional|nmod|blockade blockade|amod|END_ENTITY	Increased growth-inhibitory and cytotoxic activity of arsenic_trioxide in head_and_neck_carcinoma cells with functional p53 deficiency and resistance to EGFR blockade .
25623760	0	p53	29,32	EGFR	67,71	p53	EGFR	7157	1956	Gene	Gene	adenovirus|compound|START_ENTITY Effect|nmod|adenovirus Effect|nmod|gefitinib gefitinib|amod|END_ENTITY	-LSB- Effect of recombinant human p53 adenovirus -LRB- Ad-p53 -RRB- combined with EGFR inhibitor gefitinib on the sensitivity of breast_cancer MDA-MB-468 cells -RSB- .
9417299	0	p53	39,42	EGFR	44,48	p53	EGFR	7157	1956	Gene	Gene	expression|nmod|START_ENTITY proliferation|appos|expression END_ENTITY|nsubj|proliferation	-LSB- Cellular proliferation , expression of p53 , EGFR and apoptosis index of healthy mucosa of the bladder with TCC ; pre - and post-intravesical BCG immunohistochemical study -RSB- .
9664135	0	p53	69,72	EGFR	17,21	p53	EGFR	7157	1956	Gene	Gene	restoration|nmod|START_ENTITY levels|nmod|restoration levels|amod|END_ENTITY	Normalization of EGFR mRNA levels following restoration of wild-type p53 in a head_and_neck_squamous_cell_carcinoma cell line .
24376930	0	p53	42,45	EGFr	47,51	p53	EGFr	7157	1956	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic and predictive significance of p53 , EGFr , Ki-67 in larynx preservation treatment .
11821415	0	p53	90,93	ERK	0,3	p53	ERK	7157	5594	Gene	Gene	damage|nmod|START_ENTITY mediates|nmod|damage mediates|nsubj|activation activation|compound|END_ENTITY	ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53 .
12439598	0	p53	80,83	ERK	27,30	p53	ERK	7157	5594	Gene	Gene	death|nmod|START_ENTITY induces|dobj|death induces|nsubj|activation activation|nmod|END_ENTITY	Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines .
15363324	0	p53	47,50	ERK	95,98	p53	ERK	7157	5594	Gene	Gene	expression|dep|START_ENTITY pathways|dep|expression pathways|compound|END_ENTITY	-LSB- Overexpression of HER2/neu downregulates wild p53 protein expression via PI3K and Ras/Raf/MEK / ERK pathways in human breast_cancer cells -RSB- .
15880691	0	p53	182,185	ERK	53,56	p53	ERK	7157	5594	Gene	Gene	ERK|nmod|START_ENTITY effect|nmod|ERK lack|nmod|effect mediated|nsubj|lack leads|parataxis|mediated leads|nsubj|Inhibition Inhibition|nmod|extracellular_signal_regulated_kinase extracellular_signal_regulated_kinase|appos|END_ENTITY	Inhibition of extracellular_signal_regulated_kinase -LRB- ERK -RRB- leads to apoptosis_inducing_factor -LRB- AIF -RRB- mediated apoptosis in epithelial breast_cancer cells : the lack of effect of ERK in p53 mediated copper induced apoptosis .
16410143	0	p53	114,117	ERK	109,112	p53	ERK	7157	5594	Gene	Gene	expression|compound|START_ENTITY correlates|appos|expression correlates|nmod|END_ENTITY	Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK , p53 expression , and signaling response to U0126 .
17208232	0	p53	0,3	ERK	14,17	p53	ERK	7157	5594	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|compound|END_ENTITY	p53 regulates ERK activation in carboplatin induced apoptosis_in_cervical_carcinoma : a novel target of p53 in apoptosis .
17208232	0	p53	103,106	ERK	14,17	p53	ERK	7157	5594	Gene	Gene	target|nmod|START_ENTITY apoptosis_in_cervical_carcinoma|dep|target induced|dobj|apoptosis_in_cervical_carcinoma carboplatin|acl|induced activation|nmod|carboplatin activation|compound|END_ENTITY	p53 regulates ERK activation in carboplatin induced apoptosis_in_cervical_carcinoma : a novel target of p53 in apoptosis .
18796294	0	p53	37,40	ERK	0,3	p53	ERK	22060(Tax:10090)	26413(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death .
26956619	0	p53	68,71	ERK	0,3	p53	ERK	7157	5594	Gene	Gene	functionality|compound|START_ENTITY lack|nmod|functionality overcomes|dobj|lack mediated|ccomp|overcomes mediated|nsubj|END_ENTITY	ERK mediated upregulation of death_receptor_5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon_cancer models : efficiency of DAT1 in Ras-Raf mutated cells .
19578757	0	p53	28,31	ERalpha	50,57	p53	ERalpha	7157	2099	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions .
8649821	0	p53	17,20	ETS1	0,4	p53	ETS1	7157	2113	Gene	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	ETS1 and ETS2 in p53 regulation : spatial separation of ETS binding sites -LRB- EBS -RRB- modulate protein : DNA interaction .
22508727	0	p53	7,10	ETS2	27,31	p53	ETS2	7157	2114	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Mutant p53 cooperates with ETS2 to promote etoposide resistance .
26871468	0	p53	7,10	ETS2	20,24	p53	ETS2	7157	2114	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation .
15208672	0	p53	10,13	EZH2	55,59	p53	EZH2	7157	2146	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|gene gene|compound|END_ENTITY	Activated p53 suppresses the histone methyltransferase EZH2 gene .
16998811	0	p53	55,58	EZH2	49,53	p53	EZH2	7157	2146	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
25255445	0	p53	14,17	EZH2	64,68	p53	EZH2	7157	2146	Gene	Gene	Regulation|nmod|START_ENTITY Links|nsubj|Regulation Links|nmod|Expression Expression|compound|END_ENTITY	Regulation of p53 and Rb Links the Alternative NF-kB Pathway to EZH2 Expression and Cell Senescence .
26587974	0	p53	7,10	EZH2	19,23	p53	EZH2	7157	2146	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing .
11035041	0	p53	34,37	Egr-1	57,62	p53	Egr-1	22060(Tax:10090)	13653(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Ionizing radiation down-regulates p53 protein in primary Egr-1 - / - mouse embryonic fibroblast cells causing enhanced resistance to apoptosis .
26540344	0	p53	16,19	Ell3	0,4	p53	Ell3	7157	80237	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Ell3 stabilizes p53 following CDDP treatment via its effects on ubiquitin-dependent and - independent proteasomal degradation pathways in breast_cancer cells .
23279852	0	p53	44,47	Endothelin-1	0,12	p53	Endothelin-1	22060(Tax:10090)	13614(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis .
25573952	0	p53	7,10	Epidermal_Growth_Factor_Receptor	21,53	p53	Epidermal Growth Factor Receptor	7157	1956	Gene	Gene	Amplifies|nsubj|START_ENTITY Amplifies|dobj|Signaling Signaling|compound|END_ENTITY	Mutant p53 Amplifies Epidermal_Growth_Factor_Receptor Family Signaling to Promote Mammary Tumorigenesis .
10767376	0	p53	119,122	Epidermal_growth_factor_receptor	0,32	p53	Epidermal growth factor receptor	7157	1956	Gene	Gene	overexpression|compound|START_ENTITY correlates|nmod|overexpression correlates|nsubj|expression expression|amod|END_ENTITY	Epidermal_growth_factor_receptor expression correlates with poor prognosis in non-small_cell_lung_cancer patients with p53 overexpression .
12154062	0	p53	97,100	Epidermal_growth_factor_receptor	0,32	p53	Epidermal growth factor receptor	22060(Tax:10090)	13649(Tax:10090)	Gene	Gene	model|nummod|START_ENTITY associated|dep|model associated|nsubjpass|pathways pathways|compound|END_ENTITY	Epidermal_growth_factor_receptor signaling pathways are associated with tumorigenesis in the Nf1 : p53 mouse tumor model .
21388911	0	p53	66,69	Epidermal_growth_factor_receptor	0,32	p53	Epidermal growth factor receptor	7157	1956	Gene	Gene	accumulation|compound|START_ENTITY correlates|nmod|accumulation abundance|dobj|correlates abundance|nsubj|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- abundance correlates with p53 and Bcl-2 accumulation and patient age in a small cohort of North African nasopharyngeal_carcinoma patients .
20080630	0	p53	105,108	Estrogen_receptor	0,17	p53	Estrogen receptor	7157	2099	Gene	Gene	sequences|compound|START_ENTITY enhances|nmod|sequences enhances|nsubj|END_ENTITY	Estrogen_receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences .
20080630	0	p53	55,58	Estrogen_receptor	0,17	p53	Estrogen receptor	7157	2099	Gene	Gene	transactivation|compound|START_ENTITY enhances|dobj|transactivation enhances|nsubj|END_ENTITY	Estrogen_receptor acting in cis enhances WT and mutant p53 transactivation at canonical and noncanonical p53 target sequences .
16469747	0	p53	30,33	Estrogen_receptor-alpha	0,23	p53	Estrogen receptor-alpha	7157	2099	Gene	Gene	protein|compound|START_ENTITY binds|dobj|protein binds|nsubj|END_ENTITY	Estrogen_receptor-alpha binds p53 tumor suppressor protein directly and represses its function .
12145208	0	p53	21,24	Ets1	0,4	p53	Ets1	22060(Tax:10090)	23871(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells .
23799104	0	p53	60,63	Eukaryotic_translation_elongation_factor_1-alpha_1	0,50	p53	Eukaryotic translation elongation factor 1-alpha 1	7157	1915	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Eukaryotic_translation_elongation_factor_1-alpha_1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity .
20843368	0	p53	36,39	FATS	0,4	p53	FATS	22060(Tax:10090)	71007(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	FATS is a transcriptional target of p53 and associated with antitumor activity .
24240685	0	p53	59,62	FATS	0,4	p53	FATS	7157	118611	Gene	Gene	stabilizes|dobj|START_ENTITY ligase|acl:relcl|stabilizes ligase|nsubj|END_ENTITY	FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage .
10510470	0	p53	44,47	FBP-30	21,27	p53	FBP-30	7157	23360	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	WW domain-containing FBP-30 is regulated by p53 .
25096914	0	p53	108,111	FOXO3	76,81	p53	FOXO3	7157	2309	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Auranofin displays anticancer activity against ovarian_cancer cells through FOXO3 activation independent of p53 .
18824006	0	p53	108,111	FOXO3a	80,86	p53	FOXO3a	7157	2309	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53 .
26781862	0	p53	57,60	FOXP3	33,38	p53	FOXP3	7157	50943	Gene	Gene	Transcription|nmod|START_ENTITY Transcription|compound|END_ENTITY	Ultraviolet Irradiation Promotes FOXP3 Transcription via p53 in Psoriasis .
11446471	0	p53	67,70	Fas_ligand	55,65	p53	Fas ligand	7157	356	Gene	Gene	Fas|dep|START_ENTITY Fas|dep|END_ENTITY	Lymphoid elements and apoptosis-related proteins -LRB- Fas , Fas_ligand , p53 and bcl-2 -RRB- in lichen_sclerosus and carcinoma_of_the_vulva .
19806025	0	p53	0,3	FoxM1	39,44	p53	FoxM1	7157	2305	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	p53 negatively regulates expression of FoxM1 .
20124405	0	p53	51,54	G-protein-coupled_receptor_kinase_5	0,35	p53	G-protein-coupled receptor kinase 5	22060(Tax:10090)	14773(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	G-protein-coupled_receptor_kinase_5 phosphorylates p53 and inhibits DNA damage-induced apoptosis .
23681232	0	p53	17,20	GADD45b	0,7	p53	GADD45b	22060(Tax:10090)	17873(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY mediates|dobj|degradation mediates|nsubj|END_ENTITY	GADD45b mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment .
10531467	0	p53	133,136	GAPDH	109,114	p53	GAPDH	301300(Tax:10116)	24383(Tax:10116)	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Involvement of glyceraldehyde-3-phosphate_dehydrogenase -LRB- GAPDH -RRB- and p53 in neuronal apoptosis : evidence that GAPDH is upregulated by p53 .
16685387	0	p53	30,33	GEP	0,3	p53	GEP	7157	2896	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	GEP associates with wild-type p53 in hepatocellular_carcinoma .
22522597	0	p53	37,40	GLTSCR2	18,25	p53	GLTSCR2	7157	29997	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses .
8956789	0	p53	110,113	GSTM1	86,91	p53	GSTM1	7157	2944	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Epithelial_ovarian_cancer : influence of polymorphism at the glutathione_S-transferase GSTM1 and GSTT1 loci on p53 expression .
23948959	0	p53	42,45	Gadd45b	0,7	p53	Gadd45b	301300(Tax:10116)	299626(Tax:10116)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Gadd45b is transcriptionally activated by p53 via p38a-mediated phosphorylation during myocardial ischemic_injury .
16023592	0	p53	54,57	Gankyrin	0,8	p53	Gankyrin	7157	5716	Gene	Gene	regulator|nmod|START_ENTITY name|nmod|regulator END_ENTITY|dep|name	Gankyrin : an intriguing name for a novel regulator of p53 and RB .
21801713	0	p53	63,66	Gelsolin	0,8	p53	Gelsolin	7157	2934	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells .
23832961	0	p53	17,20	Ghrelin	0,7	p53	Ghrelin	22060(Tax:10090)	58991(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Ghrelin requires p53 to stimulate lipid storage in fat and liver .
15635261	0	p53	16,19	H2AX	78,82	p53	H2AX	7157	3014	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	No induction of p53 phosphorylation and few focus formation of phosphorylated H2AX suggest efficient repair of DNA damage during chronic low-dose-rate irradiation in human cells .
21858116	0	p53	30,33	H2AX	62,66	p53	H2AX	22060(Tax:10090)	15270(Tax:10090)	Gene	Gene	Onset|nmod|START_ENTITY mediated|nsubj|Onset mediated|dobj|down-regulation down-regulation|nmod|END_ENTITY	Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells .
17982666	0	p53	25,28	HDAC	40,44	p53	HDAC	7157	9734	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon_cancer cells in vitro and in vivo .
21346816	0	p53	17,20	HDAC3	8,13	p53	HDAC3	7157	8841	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple_sclerosis .
22006999	0	p53	0,3	HDGF	52,56	p53	HDGF	7157	3068	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p53 negatively regulates the hepatoma growth factor HDGF .
10980695	0	p53	71,74	HDM2	10,14	p53	HDM2	7157	4193	Gene	Gene	exclusion|nmod|START_ENTITY required|nmod|exclusion required|nsubjpass|domain domain|amod|intact intact|dep|END_ENTITY	An intact HDM2 RING-finger domain is required for nuclear exclusion of p53 .
11279110	0	p53	58,61	HDM2	16,20	p53	HDM2	7157	4193	Gene	Gene	degradation|nmod|START_ENTITY activity|nmod|degradation activity|nummod|END_ENTITY	Requirement for HDM2 activity in the rapid degradation of p53 in neuroblastoma .
11494132	0	p53	48,51	HDM2	25,29	p53	HDM2	7157	4193	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|product product|compound|END_ENTITY	An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2 .
11494132	0	p53	48,51	HDM2	75,79	p53	HDM2	7157	4193	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|advcl|inhibiting inhibiting|dobj|END_ENTITY	An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2 .
15314174	0	p53	37,40	HDM2	14,18	p53	HDM2	7157	4193	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of HDM2 and activation of p53 by ribosomal_protein_L23 .
15693891	0	p53	76,79	HDM2	0,4	p53	HDM2	7157	4193	Gene	Gene	suppressor|compound|START_ENTITY deregulate|dobj|suppressor deregulate|nsubj|overexpression overexpression|compound|END_ENTITY	HDM2 overexpression and focal loss of p14/ARF expression may deregulate the p53 tumour suppressor pathway in meningeal_haemangiopericytomas .
15715460	0	p53	88,91	HDM2	57,61	p53	HDM2	7157	4193	Gene	Gene	activate|dobj|START_ENTITY activate|advmod|that that|nmod:npmod|antagonists antagonists|nummod|END_ENTITY	Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells .
15862297	0	p53	61,64	HDM2	0,4	p53	HDM2	7157	4193	Gene	Gene	phosphorylation|nmod|START_ENTITY affects|dobj|phosphorylation affects|nsubj|END_ENTITY	HDM2 negatively affects the Chk2-mediated phosphorylation of p53 .
15950904	0	p53	83,86	HDM2	29,33	p53	HDM2	7157	4193	Gene	Gene	stabilize|dobj|START_ENTITY stabilize|nsubj|inhibitors inhibitors|nmod|activity activity|compound|END_ENTITY	Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells .
16360036	0	p53	59,62	HDM2	12,16	p53	HDM2	7157	4193	Gene	Gene	target|nmod|START_ENTITY target|compound|END_ENTITY	hnRNP_K : an HDM2 target and transcriptional coactivator of p53 in response to DNA damage .
16432196	0	p53	62,65	HDM2	22,26	p53	HDM2	7157	4193	Gene	Gene	site|nmod|START_ENTITY provides|dobj|site provides|nsubj|region region|nmod|END_ENTITY	The central region of HDM2 provides a second binding site for p53 .
17698841	0	p53	17,20	HDM2	98,102	p53	HDM2	7157	4193	Gene	Gene	Stabilization|nmod|START_ENTITY associated|nsubjpass|Stabilization associated|nmod|sequestration sequestration|nmod|END_ENTITY	Stabilization of p53 in human_cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination .
19433585	0	p53	69,72	HDM2	88,92	p53	HDM2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY degradation|nmod|END_ENTITY	A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage .
19880322	0	p53	55,58	HDM2	30,34	p53	HDM2	7157	4193	Gene	Gene	binding|nmod|START_ENTITY inhibitors|amod|binding inhibitors|nmod|END_ENTITY	N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53 .
20542919	0	p53	41,44	HDM2	23,27	p53	HDM2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY attenuate|dobj|degradation regulation|acl|attenuate regulation|nmod|END_ENTITY	Negative regulation of HDM2 to attenuate p53 degradation by ribosomal_protein_L26 .
21993556	0	p53	0,3	HDM2	19,23	p53	HDM2	7157	4193	Gene	Gene	rescue|compound|START_ENTITY rescue|nmod|antagonism antagonism|compound|END_ENTITY	p53 rescue through HDM2 antagonism suppresses melanoma growth and potentiates MEK inhibition .
22989009	0	p53	87,90	HDM2	0,4	p53	HDM2	7157	4193	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|MI-219 MI-219|compound|END_ENTITY	HDM2 antagonist MI-219 -LRB- spiro-oxindole -RRB- , but not Nutlin-3 -LRB- cis-imidazoline -RRB- , regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant_B-cell_lymphomas .
22989009	0	p53	87,90	HDM2	108,112	p53	HDM2	7157	4193	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|autoubiquitination autoubiquitination|compound|END_ENTITY	HDM2 antagonist MI-219 -LRB- spiro-oxindole -RRB- , but not Nutlin-3 -LRB- cis-imidazoline -RRB- , regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant_B-cell_lymphomas .
24113239	0	p53	43,46	HDM2	65,69	p53	HDM2	7157	4193	Gene	Gene	inhibitors|nmod|START_ENTITY derivatives|nmod|inhibitors ubiquitination|nsubj|derivatives ubiquitination|nmod|END_ENTITY	5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2 .
24314634	0	p53	44,47	HDM2	73,77	p53	HDM2	7157	4193	Gene	Gene	BOX|nsubj|START_ENTITY BOX|xcomp|motif motif|nmod|END_ENTITY	Human_herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization .
11280734	0	p53	78,81	HDMX	23,27	p53	HDMX	7157	4194	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|nmod|proteins proteins|compound|END_ENTITY	Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53 .
20472715	0	p53	15,18	HDMX	0,4	p53	HDMX	7157	4193	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	HDMX regulates p53 activity and confers chemoresistance to 3-bis -LRB- 2-chloroethyl -RRB- -1 - nitrosourea .
22700878	0	p53	89,92	HDMX	40,44	p53	HDMX	7157	4194	Gene	Gene	mutation|compound|START_ENTITY offers|nmod|mutation offers|nsubj|splicing splicing|nmod|END_ENTITY	Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer .
24813712	0	p53	23,26	HDMX	0,4	p53	HDMX	7157	4193	Gene	Gene	mRNA|compound|START_ENTITY folds|dobj|mRNA folds|nsubj|END_ENTITY	HDMX folds the nascent p53 mRNA following activation by the ATM kinase .
15221598	0	p53	30,33	HER-2	35,40	p53	HER-2	7157	2064	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation and expression of p53 , HER-2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and e-cadherin in a high-risk breast-cancer population .
17604627	0	p53	21,24	HER2	54,58	p53	HER2	7157	2064	Gene	Gene	expression|compound|START_ENTITY expression|nmod|signaling signaling|compound|END_ENTITY	Relationship between p53 and p27 expression following HER2 signaling .
24722987	0	p53	78,81	HERC2	32,37	p53	HERC2	7157	8924	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	The E3 ubiquitin protein ligase HERC2 modulates the activity of tumor protein p53 by regulating its oligomerization .
11375890	0	p53	80,83	HIF-1	14,19	p53	HIF-1	7157	3091	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Inhibition of HIF-1 - and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions .
22689594	0	p53	18,21	HIF-2a	0,6	p53	HIF-2a	7157	2034	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	HIF-2a suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells .
11532197	0	p53	47,50	HIPK2	0,5	p53	HIPK2	7157	28996	Gene	Gene	protein|compound|START_ENTITY stabilization|nmod|protein leads|nmod|stabilization leads|nsubj|overexpression overexpression|compound|END_ENTITY	HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels .
12851404	0	p53	90,93	HIPK2	56,61	p53	HIPK2	7157	28996	Gene	Gene	activity|compound|START_ENTITY regulating|dobj|activity partners|acl|regulating partners|nsubj|TP53INP1s TP53INP1s|appos|END_ENTITY	TP53INP1s and homeodomain-interacting_protein_kinase-2 -LRB- HIPK2 -RRB- are partners in regulating p53 activity .
12907596	0	p53	78,81	HIPK2	62,67	p53	HIPK2	7157	28996	Gene	Gene	phosphorylation|compound|START_ENTITY homeodomain-interacting_protein_kinase_2|dep|phosphorylation homeodomain-interacting_protein_kinase_2|appos|END_ENTITY	PML is required for homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- - mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains .
15122315	0	p53	43,46	HIPK2	0,5	p53	HIPK2	7157	28996	Gene	Gene	activity|compound|START_ENTITY rescuing|dobj|activity inhibition|acl|rescuing neutralizes|dobj|inhibition neutralizes|nsubj|END_ENTITY	HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function .
15526030	0	p53	16,19	HIPK2	47,52	p53	HIPK2	7157	28996	Gene	Gene	functions|compound|START_ENTITY stimulates|dobj|functions stimulates|nmod|activation activation|nmod|kinase kinase|compound|END_ENTITY	Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation .
15897882	0	p53	35,38	HIPK2	0,5	p53	HIPK2	7157	28996	Gene	Gene	acetylation|compound|START_ENTITY contributes|nmod|acetylation contributes|nsubj|END_ENTITY	HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage .
16601678	0	p53	30,33	HIPK2	77,82	p53	HIPK2	7157	28996	Gene	Gene	response|compound|START_ENTITY control|nmod|response control|nmod|END_ENTITY	Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2 .
17290307	0	p53	32,35	HIPK2	96,101	p53	HIPK2	7157	28996	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nmod|relocalization relocalization|nmod|END_ENTITY	High-mobility_group_A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 .
19642869	0	p53	30,33	HIPK2	63,68	p53	HIPK2	7157	28996	Gene	Gene	response|compound|START_ENTITY control|nmod|response control|nmod|degradation degradation|compound|END_ENTITY	Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation .
19828042	0	p53	16,19	HIPK2	0,5	p53	HIPK2	7157	28996	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	HIPK2 modulates p53 activity towards pro-apoptotic transcription .
20018442	0	p53	49,52	HIPK2	93,98	p53	HIPK2	7157	28996	Gene	Gene	phosphorylation|nummod|START_ENTITY suppresses|dobj|phosphorylation suppresses|advcl|triggering triggering|dobj|degradation degradation|compound|END_ENTITY	Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation .
20514025	0	p53	14,17	HIPK2	30,35	p53	HIPK2	7157	28996	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Regulation of p53 activity by HIPK2 : molecular mechanisms and therapeutical implications in human cancer cells .
20876941	0	p53	9,12	HIPK2	60,65	p53	HIPK2	7157	28996	Gene	Gene	is|dobj|START_ENTITY is|nsubj|link link|compound|END_ENTITY	Unfolded p53 in the pathogenesis of Alzheimer 's _ disease : is HIPK2 the link ?
22110707	0	p53	28,31	HIPK2	73,78	p53	HIPK2	7157	28996	Gene	Gene	phosphorylation|compound|START_ENTITY prevents|dobj|phosphorylation prevents|nmod|interaction interaction|nmod|END_ENTITY	Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2 .
24177473	0	p53	44,47	HIPK2	108,113	p53	HIPK2	7157	28996	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nmod|relocalization relocalization|nmod|END_ENTITY	Retraction : High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 .
24196445	0	p53	35,38	HIPK2	59,64	p53	HIPK2	22060(Tax:10090)	15258(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY modulates|dobj|pathway modulates|advcl|altering altering|dobj|localization localization|compound|END_ENTITY	Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization .
25313037	0	p53	33,36	HIPK2	69,74	p53	HIPK2	7157	28996	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|activation activation|nmod|END_ENTITY	XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313 .
20036050	0	p53	17,20	HMGB2	0,5	p53	HMGB2	7157	3148	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	HMGB2 stabilizes p53 by interfering with E6/E6AP-mediated p53 degradation in human_papillomavirus-positive HeLa cells .
15044858	0	p53	17,20	HOXA10	0,6	p53	HOXA10	7157	3206	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HOXA10 regulates p53 expression and matrigel invasion in human breast_cancer cells .
18263706	0	p53	16,19	HSP27	0,5	p53	HSP27	7157	3315	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells : p21 upregulation and G2/M phase cell cycle arrest .
23251530	0	p53	30,33	HSP70	61,66	p53	HSP70	22060(Tax:10090)	15511(Tax:10090)	Gene	Gene	stabilization|compound|START_ENTITY mechanism|nmod|stabilization mechanism|dep|role role|nmod|END_ENTITY	Molecular mechanism of mutant p53 stabilization : the role of HSP70 and MDM2 .
7718482	0	p53	74,77	HSP70	48,53	p53	HSP70	7157	3308	Gene	Gene	genes|compound|START_ENTITY promoter|nmod|genes promoter|compound|END_ENTITY	Response of heat_shock element within the human HSP70 promoter to mutated p53 genes .
9235949	0	p53	52,55	HSP70	0,5	p53	HSP70	7157	3308	Gene	Gene	sites|nmod|START_ENTITY sites|nummod|END_ENTITY	HSP70 binding sites in the tumor suppressor protein p53 .
21478269	0	p53	101,104	HSP90	55,60	p53	HSP90	7157	3320	Gene	Gene	stabilization|nmod|START_ENTITY causes|dobj|stabilization causes|nsubj|inactivation inactivation|nmod|END_ENTITY	Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells .
8841381	0	p53	46,49	HT1080	67,73	p53	HT1080	7157	8872	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	HSP binding and mitochondrial localization of p53 protein in human HT1080 and mouse C3H10T1/2 cell lines .
17933770	0	p53	146,149	Haeme-oxygenase_1	116,133	p53	Haeme-oxygenase 1	22060(Tax:10090)	15368(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	p53-dependent stimulation of redox-related genes in the lymphoid organs of gamma-irradiated -- mice identification of Haeme-oxygenase_1 as a direct p53 target gene .
10077639	0	p53	93,96	Hdm2	43,47	p53	Hdm2	7157	4193	Gene	Gene	degradation|nmod|START_ENTITY required|nmod|degradation required|nsubjpass|shuttling shuttling|nmod|END_ENTITY	Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53 .
11562347	0	p53	65,68	Hdm2	99,103	p53	Hdm2	7157	4193	Gene	Gene	glucocorticoid_receptor|nmod|START_ENTITY interaction|nmod|glucocorticoid_receptor enhances|nsubj|interaction enhances|nmod|END_ENTITY	Ligand-dependent interaction of the glucocorticoid_receptor with p53 enhances their degradation by Hdm2 .
11744695	0	p53	83,86	Hdm2	37,41	p53	Hdm2	7157	4193	Gene	Gene	stability|compound|START_ENTITY regulate|dobj|stability ability|acl|regulate essential|nmod|ability essential|nsubj|recruitment recruitment|nmod|nucleus nucleus|nmod|END_ENTITY	Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation .
16227590	0	p53	41,44	Hdm2	87,91	p53	Hdm2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY accelerates|dobj|degradation accelerates|nmod|actions actions|nmod|END_ENTITY	Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen_synthase_kinase_3beta .
16432175	0	p53	43,46	Hdm2	38,42	p53	Hdm2	7157	4193	Gene	Gene	proliferation|compound|START_ENTITY inhibitors|dep|proliferation inhibitors|nmod|END_ENTITY	Benzodiazepinedione inhibitors of the Hdm2 : p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo .
16751805	0	p53	56,59	Hdm2	19,23	p53	Hdm2	7157	4193	Gene	Gene	stabilization|compound|START_ENTITY leading|nmod|stabilization pathways|acl|leading inhibits|nmod|pathways inhibits|dobj|END_ENTITY	Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization .
16965791	0	p53	84,87	Hdm2	26,30	p53	Hdm2	7157	4193	Gene	Gene	ubiquitination|nmod|START_ENTITY critical|nmod|ubiquitination structure|amod|critical structure|nmod|RING RING|compound|END_ENTITY	Solution structure of the Hdm2 C2H2C4 RING , a domain critical for ubiquitination of p53 .
18723490	0	p53	33,36	Hdm2	71,75	p53	Hdm2	7157	4193	Gene	Gene	expressing|dobj|START_ENTITY expressing|nmod|inhibitor inhibitor|nmod|END_ENTITY	Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2 .
19920202	0	p53	56,59	Hdm2	73,77	p53	Hdm2	7157	4193	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Suppression of hypoxia-inducible_factor_2alpha restores p53 activity via Hdm2 and reverses chemoresistance of renal_carcinoma cells .
20124454	8	p53	1644,1647	Hdm2	1722,1726	p21	KRAS	644914	3845	Gene	Gene	increased|nsubj|START_ENTITY increased|dobj|expression expression|amod|END_ENTITY	Transduction of KRAS -LRB- aMut -RRB- / p53 -LRB- wild -RRB- HCT116 , LoVo , and LS174T cells by Ad-KRhdm2 significantly increased Hdm2 expression , decreased p53 level , and abolished the p53-transactivating p21 -LRB- Cip1 -RRB- promoter activity .
14507994	0	p53	64,67	HdmX	0,4	p53	HdmX	7157	4193	Gene	Gene	ubiquitination|nmod|START_ENTITY stimulates|dobj|ubiquitination stimulates|nsubj|END_ENTITY	HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 .
19153082	0	p53	56,59	HdmX	34,38	p53	HdmX	7157	4193	Gene	Gene	Changes|nummod|START_ENTITY Complex|nmod|Changes Structures|nmod|Complex Structures|appos|END_ENTITY	Crystal Structures of Human MdmX -LRB- HdmX -RRB- in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes .
19946469	0	p53	141,144	HdmX	77,81	p53	HdmX	7157	4193	Gene	Gene	harboring|dobj|START_ENTITY cells|acl|harboring knockdown|nmod|cells knockdown|nsubj|Alterations Alterations|nmod|expression expression|nmod|stress stress|nmod|END_ENTITY	Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 .
11494153	0	p53	54,57	Hdmx	0,4	p53	Hdmx	7157	4193	Gene	Gene	repress|nmod|START_ENTITY repress|nsubj|END_ENTITY	Hdmx and Mdm2 can repress transcription activation by p53 but not by p63 .
11744695	0	p53	83,86	Hdmx	0,4	p53	Hdmx	7157	4193	Gene	Gene	stability|compound|START_ENTITY regulate|dobj|stability ability|acl|regulate essential|nmod|ability essential|nsubj|recruitment recruitment|compound|END_ENTITY	Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation .
16905769	0	p53	30,33	Hdmx	0,4	p53	Hdmx	7157	4193	Gene	Gene	activation|compound|START_ENTITY outcome|nmod|activation modulates|dobj|outcome modulates|nsubj|END_ENTITY	Hdmx modulates the outcome of p53 activation in human tumor cells .
17640893	0	p53	78,81	Hdmx	57,61	p53	Hdmx	7157	4193	Gene	Gene	activation|compound|START_ENTITY degradation|nmod|activation degradation|compound|END_ENTITY	Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation .
24022481	0	p53	102,105	Hepatocyte_nuclear_factor_6	0,27	p53	Hepatocyte nuclear factor 6	7157	3175	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Hepatocyte_nuclear_factor_6 suppresses the migration and invasive growth of lung_cancer cells through p53 and the inhibition of epithelial-mesenchymal transition .
17290307	0	p53	32,35	High-mobility_group_A1	0,22	p53	High-mobility group A1	7157	3159	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	High-mobility_group_A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 .
21785465	0	p53	22,25	Hipk2	0,5	p53	Hipk2	22060(Tax:10090)	15258(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Hipk2 cooperates with p53 to suppress y-ray radiation-induced mouse thymic_lymphoma .
25072962	0	p53	31,34	Histone_deacetylase_2	0,21	p53	Histone deacetylase 2	7157	3066	Gene	Gene	controls|dobj|START_ENTITY controls|nsubj|END_ENTITY	Histone_deacetylase_2 controls p53 and is a critical factor in tumorigenesis .
12019172	0	p53	31,34	Histone_deacetylase_5	0,21	p53	Histone deacetylase 5	7157	10014	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Histone_deacetylase_5 is not a p53 target gene , but its overexpression inhibits tumor cell growth and induces apoptosis .
11780126	0	p53	56,59	Homeodomain-interacting_protein_kinase-2	0,40	p53	Homeodomain-interacting protein kinase-2	7157	28996	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Homeodomain-interacting_protein_kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis .
18089808	0	p53	16,19	Hsp27	0,5	p53	Hsp27	7157	3315	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Hsp27 modulates p53 signaling and suppresses cellular senescence .
20587688	0	p53	81,84	Hsp27	125,130	p53	Hsp27	7157	3315	Gene	Gene	proteins|dep|START_ENTITY proteins|dep|END_ENTITY	Canine gastric_carcinoma : immunohistochemical expression of cell cycle proteins -LRB- p53 , p21 , and p16 -RRB- and heat_shock proteins -LRB- Hsp27 and Hsp70 -RRB- .
23357534	0	p53	45,48	Hsp27	15,20	p53	Hsp27	7157	3315	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells to doxorubicin-induced apoptosis .
19749793	0	p53	51,54	Hsp70	0,5	p53	Hsp70	7157	3308	Gene	Gene	activity|compound|START_ENTITY support|dobj|activity required|xcomp|support required|nsubjpass|chaperones chaperones|amod|END_ENTITY	Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions .
20153329	0	p53	53,56	Hsp70	36,41	p53	Hsp70	7157	3308	Gene	Gene	interaction|compound|START_ENTITY Reconstitution|dep|interaction Reconstitution|nmod|END_ENTITY	Reconstitution of the mitochondrial Hsp70 -LRB- mortalin -RRB- - p53 interaction using purified proteins -- identification of additional interacting regions .
22933182	0	p53	31,34	Hsp70	127,132	p53	Hsp70	7157	3308	Gene	Gene	cells|compound|START_ENTITY Radiosensitization|nmod|cells associated|nsubjpass|Radiosensitization associated|nmod|levels levels|appos|END_ENTITY	Radiosensitization of wildtype p53 cancer cells by the MDM2-inhibitor PXN727 is associated with altered heat_shock_protein_70 -LRB- Hsp70 -RRB- levels .
24678590	0	p53	103,106	Hsp70	86,91	p53	Hsp70	7157	3308	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines .
8940078	0	p53	74,77	Hsp70	102,107	p53	Hsp70	22060(Tax:10090)	15511(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nmod|END_ENTITY	Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70 .
12163643	0	p53	26,29	Hsp90	85,90	p53	Hsp90	7157	3320	Gene	Gene	domain|compound|START_ENTITY domain|acl|bound bound|nmod|END_ENTITY	CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90 .
15358769	0	p53	27,30	Hsp90	0,5	p53	Hsp90	7157	3320	Gene	Gene	protein|compound|START_ENTITY chaperones|dobj|protein chaperones|nsubj|END_ENTITY	Hsp90 chaperones wild-type p53 tumor suppressor protein .
15358771	0	p53	42,45	Hsp90	0,5	p53	Hsp90	7157	3320	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures .
15613472	0	p53	150,153	Hsp90	0,5	p53	Hsp90	7157	3320	Gene	Gene	stabilization|nmod|START_ENTITY functions|dep|stabilization restoring|dobj|functions essential|advcl|restoring essential|nsubj|END_ENTITY	Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53 : implications for cancer therapy .
15613472	0	p53	77,80	Hsp90	0,5	p53	Hsp90	7157	3320	Gene	Gene	protein|compound|START_ENTITY functions|nmod|protein restoring|dobj|functions essential|advcl|restoring essential|nsubj|END_ENTITY	Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53 : implications for cancer therapy .
17982489	0	p53	62,65	Hsp90	0,5	p53	Hsp90	7157	3320	Gene	Gene	effects|nmod|START_ENTITY has|dobj|effects has|nsubj|inhibition inhibition|amod|END_ENTITY	Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic_lymphocytic_leukaemia cells .
19956882	0	p53	0,3	Hsp90	74,79	p53	Hsp90	7157	3320	Gene	Gene	radio-sensitization|compound|START_ENTITY radio-sensitization|nmod|lines lines|nmod|END_ENTITY	p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin .
20688913	0	p53	64,67	Hsp90	15,20	p53	Hsp90	7157	3320	Gene	Gene	protein|compound|START_ENTITY chaperoning|nmod|protein sufficient|nmod|chaperoning sufficient|nsubj|binding binding|nmod|END_ENTITY	ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein .
21109931	0	p53	27,30	Hsp90	0,5	p53	Hsp90	7157	3320	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|inhibition inhibition|amod|END_ENTITY	Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma .
21460846	0	p53	19,22	Hsp90	77,82	p53	Hsp90	7157	3320	Gene	Gene	adopts|nsubj|START_ENTITY adopts|dobj|state state|nmod|presence presence|nmod|END_ENTITY	The client protein p53 adopts a molten globule-like state in the presence of Hsp90 .
21658391	0	p53	53,56	Hsp90	23,28	p53	Hsp90	7157	3320	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Dynamic Interaction of Hsp90 with Its Client Protein p53 .
24451373	0	p53	0,3	Hsp90	22,27	p53	Hsp90	7157	3320	Gene	Gene	protein|compound|START_ENTITY regulates|nsubj|protein regulates|dobj|activity activity|amod|END_ENTITY	p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression .
24736433	0	p53	0,3	Hsp90	14,19	p53	Hsp90	7157	3320	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|amod|END_ENTITY	p53 modulates Hsp90 ATPase activity and regulates aryl_hydrocarbon_receptor signaling .
26277488	0	p53	52,55	Hsp90	73,78	p53	Hsp90	7157	3320	Gene	Gene	activator|nmod|START_ENTITY Prediction|nmod|activator Prediction|nmod|END_ENTITY	Prediction of dual agents as an activator of mutant p53 and inhibitor of Hsp90 by docking , molecular dynamic simulation and virtual screening .
12905636	0	p53	54,57	Hsp90_beta	61,71	p53	Hsp90 beta	7157	3326	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- The role of p53 binding site on the trans binding of p53 to Hsp90_beta gene -RSB- .
18996350	0	p53	0,3	Hsp90beta	14,23	p53	Hsp90beta	7157	3326	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p53 regulates Hsp90beta during arsenite-induced cytotoxicity in glutathione-deficient cells .
14517280	0	p53	59,62	HuR	37,40	p53	HuR	7157	1994	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal_carcinoma cells .
21402775	0	p53	60,63	Hzf	45,48	p53	Hzf	7157	25946	Gene	Gene	activation|compound|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Cooperative role of the RNA-binding proteins Hzf and HuR in p53 activation .
12660163	0	p53	0,3	ICAM-1	14,20	p53	ICAM-1	7157	3383	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|amod|END_ENTITY	p53 activates ICAM-1 -LRB- CD54 -RRB- expression in an NF-kappaB-independent manner .
25026345	0	p53	130,133	ICAM-1	121,127	p53	ICAM-1	7157	3383	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
12925527	0	p53	51,54	IFI16	0,5	p53	IFI16	7157	3428	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	IFI16 as a negative regulator in the regulation of p53 and p21 -LRB- Waf1 -RRB- .
14990579	0	p53	51,54	IFI16	15,20	p53	IFI16	7157	3428	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation .
15728246	0	p53	82,85	IFI16	42,47	p53	IFI16	7157	3428	Gene	Gene	activity|compound|START_ENTITY triggers|dobj|activity triggers|nsubj|Up-regulation Up-regulation|nmod|gene gene|compound|END_ENTITY	Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells .
17981542	0	p53	121,124	IFI16	31,36	p53	IFI16	7157	3428	Gene	Gene	SER37|compound|START_ENTITY phosphorylation|nmod|SER37 leading|nmod|phosphorylation NBS1|acl|leading induces|dobj|NBS1 induces|nsubj|Loss Loss|nmod|END_ENTITY	Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37 .
18974396	0	p53	83,86	IFI16	57,62	p53	IFI16	7157	3428	Gene	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubj|Expression Expression|nmod|gene gene|appos|END_ENTITY	Expression of an IFN-inducible cellular senescence gene , IFI16 , is up-regulated by p53 .
25544361	0	p53	125,128	IFI16	51,56	p53	IFI16	7157	3428	Gene	Gene	activation|compound|START_ENTITY associated|nmod|activation associated|nsubjpass|redistribution redistribution|nmod|END_ENTITY	Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular_carcinoma_cells in vitro is associated with p53 activation .
20182617	0	p53	0,3	IGF-1	22,27	p53	IGF-1	7157	3479	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	p53 regulation of the IGF-1 / AKT/mTOR pathways and the endosomal compartment .
20504360	0	p53	146,149	IGF-1	23,28	p53	IGF-1	7157	3479	Gene	Gene	Wnt|nmod|START_ENTITY Wnt|dep|induced induced|dep|END_ENTITY	Resveratrol suppresses IGF-1 induced human colon_cancer cell proliferation and elevates apoptosis via suppression of IGF-1R / Wnt and activation of p53 signaling pathways .
15661074	0	p53	29,32	IGFBP3	56,62	p53	IGFBP3	7157	3486	Gene	Gene	sequence|compound|START_ENTITY sequence|nmod|END_ENTITY	Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation .
21095038	0	p53	12,15	IGFBP7	0,6	p53	IGFBP7	7157	3490	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	IGFBP7 is a p53 target gene inactivated in human lung_cancer by DNA hypermethylation .
9588214	0	p53	19,22	IGF_I	0,5	p53	IGF I	7157	3479	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	IGF_I induction of p53 requires activation of MAP kinase in cardiac muscle cells .
25544504	0	p53	70,73	IL-17	0,5	p53	IL-17	7157	3605	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression induces|advcl|suppressing induces|nsubj|END_ENTITY	IL-17 induces radiation resistance of B_lymphoma cells by suppressing p53 expression and thereby inhibiting irradiation-triggered apoptosis .
9647240	0	p53	32,35	IL-6	14,18	p53	IL-6	7157	3569	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of IL-6 signaling by p53 : STAT3 - and STAT5-masking in p53-Val135-containing human hepatoma Hep3B cell lines .
15882981	0	p53	71,74	ING4	31,35	p53	ING4	7157	51147	Gene	Gene	plays|nmod|START_ENTITY plays|nsubj|signal signal|nmod|END_ENTITY	Nuclear localization signal of ING4 plays a key role in its binding to p53 .
23967213	0	p53	22,25	ING4	4,8	p53	ING4	7157	51147	Gene	Gene	Binding|nmod|START_ENTITY Binding|compound|END_ENTITY	The ING4 Binding with p53 and Induced p53 Acetylation were Attenuated by Human_Papillomavirus_16 E6 .
11102889	0	p53	84,87	INK4A	93,98	p53	INK4A	7157	1029	Gene	Gene	START_ENTITY|appos|p16 p16|appos|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
16998811	0	p53	55,58	INK4A	64,69	p53	INK4A	7157	1029	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
27076841	0	p53	0,3	INK4A	27,32	p53	INK4A	7157	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	p53 expression but not p16 -LRB- INK4A -RRB- correlates with human_papillomavirus-associated esophageal_squamous_cell_carcinoma in Kazakh population .
10922393	0	p53	46,49	INK4a	24,29	p53	INK4a	7157	1029	Gene	Gene	families|nummod|START_ENTITY alterations|nmod|families alterations|nsubj|Absence Absence|appos|END_ENTITY	Absence of germline p16 -LRB- INK4a -RRB- alterations in p53 wild type Li-Fraumeni_syndrome families .
10986054	0	p53	66,69	INK4a	32,37	p53	INK4a	7157	1029	Gene	Gene	mutation|compound|START_ENTITY hypermethylation|appos|mutation END_ENTITY|dep|hypermethylation	Differential frequencies of p16 -LRB- INK4a -RRB- promoter hypermethylation , p53 mutation , and K-ras mutation in exfoliative material mark the development of lung_cancer in symptomatic chronic smokers .
11313791	0	p53	32,35	INK4a	44,49	p53	INK4a	7157	1029	Gene	Gene	transfer|nmod|START_ENTITY transfer|appos|END_ENTITY	Adenovirus-mediated transfer of p53 and p16 -LRB- INK4a -RRB- results in pancreatic_cancer regression in vitro and in vivo .
11777345	0	p53	23,26	INK4a	33,38	p53	INK4a	7157	1029	Gene	Gene	-|compound|START_ENTITY -|appos|END_ENTITY	Expression profiles of p53 - , p16 -LRB- INK4a -RRB- - , and telomere-regulating genes in replicative senescent primary human , mouse , and chicken fibroblast cells .
17152048	0	p53	41,44	INK4a	18,23	p53	INK4a	7157	1029	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Comparison of p16 -LRB- INK4a -RRB- expression with p53 alterations in head_and_neck_cancer by tissue microarray analysis .
19069712	0	p53	55,58	INK4a	67,72	p53	INK4a	7157	1029	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	-LSB- Histopathological characteristics and coexpression of p53 and p16 -LRB- INK4a -RRB- proteins in renal_cancer -RSB- .
25410620	0	p53	111,114	INK4a	123,128	p53	INK4a	301300(Tax:10116)	25163(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down-regulation of p53 and p16 -LRB- INK4a -RRB- genes in rat liver .
20429933	0	p53	13,16	ISG20L1	0,7	p53	ISG20L1	7157	64782	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy .
18158619	0	p53	48,51	Id-1	0,4	p53	Id-1	7157	3397	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast_cancer cells .
21608079	0	p53	0,3	Id2	23,26	p53	Id2	7157	3398	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|END_ENTITY	p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells .
15969767	0	p53	14,17	IkappaBalpha	30,42	p53	IkappaBalpha	7157	4792	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Modulation of p53 activity by IkappaBalpha : evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors .
11756558	0	p53	43,46	Ink4a	23,28	p53	Ink4a	22060(Tax:10090)	12578(Tax:10090)	Gene	Gene	roles|dep|START_ENTITY roles|nmod|p16 p16|appos|END_ENTITY	Obligate roles for p16 -LRB- Ink4a -RRB- and p19 -LRB- Arf -RRB- - p53 in the suppression of murine pancreatic neoplasia .
11514062	0	p53	35,38	Insulin_receptor	0,16	p53	Insulin receptor	301300(Tax:10116)	24954(Tax:10116)	Gene	Gene	localization|compound|START_ENTITY localization|amod|END_ENTITY	Insulin_receptor substrate protein p53 localization in rats suggests mechanism for specific polyglutamine_neurodegeneration .
20195830	0	p53	98,101	Interferon-gamma	0,16	p53	Interferon-gamma	7157	3458	Gene	Gene	activation|nmod|START_ENTITY enhances|nmod|activation enhances|nsubj|END_ENTITY	Interferon-gamma enhances the apoptosis of macrophages under trophic stress through activation of p53 and the JAK1 pathway .
7723404	0	p53	57,60	Interferon-gamma	0,16	p53	Interferon-gamma	7157	3458	Gene	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced inhibits|dobj|apoptosis inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits apoptosis induced by wild-type p53 , cytotoxic anti-cancer agents and viability factor deprivation in myeloid cells .
22888789	0	p53	58,61	Interferon_regulatory_factor_4_binding_protein	0,46	p53	Interferon regulatory factor 4 binding protein	7157	50619	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Interferon_regulatory_factor_4_binding_protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast_cancer cells .
24531714	0	p53	28,31	Interleukin_6	0,13	p53	Interleukin 6	7157	3569	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Interleukin_6 downregulates p53 expression and activity by stimulating ribosome biogenesis : a new pathway connecting inflammation to cancer .
23376847	0	p53	0,3	JMJD2b	57,63	p53	JMJD2b	7157	23030	Gene	Gene	promotes|nsubj|START_ENTITY promotes|advcl|regulating regulating|dobj|END_ENTITY	p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression .
26025680	0	p53	21,24	JMJD5	0,5	p53	JMJD5	7157	79831	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	JMJD5 interacts with p53 and negatively regulates p53 function in control of cell cycle and proliferation .
10656807	0	p53	76,79	JNK	12,15	p53	JNK	7157	5599	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability contribution|nmod|regulation contribution|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of JNK , Mdm2 and p14 -LRB- ARF -RRB- contribution to the regulation of mutant p53 stability .
14724588	0	p53	54,57	JNK	14,17	p53	JNK	7157	5599	Gene	Gene	independent|nmod|START_ENTITY proliferation|amod|independent reduces|dobj|proliferation reduces|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of JNK reduces G2/M transit independent of p53 , leading to endoreduplication , decreased proliferation , and apoptosis in breast_cancer cells .
15778501	0	p53	34,37	JNK	115,118	p53	JNK	7157	5599	Gene	Gene	regulate|dobj|START_ENTITY regulate|parataxis|links links|nsubj|END_ENTITY	JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix : JNK links FAK and p53 .
17125918	0	p53	60,63	JNK	135,138	p53	JNK	7157	5599	Gene	Gene	pathway|compound|START_ENTITY pathway|acl|requiring requiring|advcl|signalling signalling|nmod|END_ENTITY	Simvastatin induces apoptosis in human breast_cancer cells : p53 and estrogen_receptor independent pathway requiring signalling through JNK .
21763279	0	p53	0,3	JNK	118,121	p53	JNK	7157	5599	Gene	Gene	activation|compound|START_ENTITY inhibits|nsubj|activation inhibits|dobj|apoptosis apoptosis|nmod|suppression suppression|nmod|activation activation|compound|END_ENTITY	p53 activation inhibits ochratoxin_A-induced apoptosis in monkey and human kidney epithelial cells via suppression of JNK activation .
22276160	0	p53	10,13	JNK	18,21	p53	JNK	7157	5599	Gene	Gene	START_ENTITY|nmod|pathway pathway|compound|END_ENTITY	Targeting p53 via JNK pathway : a novel role of RITA for apoptotic signaling in multiple_myeloma .
22467874	3	p53	520,523	JNK	421,424	JNK	p53	44801(Tax:7227)	22060(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY fibroblasts|nmod|loss p53|nmod|fibroblasts dependent|nmod|p53 dependent|nsubj|extent extent|nmod|activity activity|compound|END_ENTITY	Likewise , the extent of JNK activity after UV irradiation is dependent on p53 in murine embryonic fibroblasts with loss of p53 resulting in diminished JNK activity .
24366007	0	p53	92,95	JNK	47,50	p53	JNK	7157	5599	Gene	Gene	manner|nmod|START_ENTITY END_ENTITY|nmod|manner	Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53 .
24413150	0	p53	41,44	JNK	28,31	p53	JNK	7157	5599	Gene	Gene	converts|dobj|START_ENTITY converts|nsubj|activation activation|nmod|END_ENTITY	ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis .
26112108	0	p53	32,35	JNK	8,11	p53	JNK	7157	5599	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Contribution of p53 into Growth Potential of Mesenchymal Progenitor Cells In Vitro .
26388570	0	p53	32,35	JNK	8,11	p53	JNK	7157	5599	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor .
26388570	0	p53	32,35	JNK	8,11	p53	JNK	7157	5599	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Contribution of p53 to the Realization of the Growth Potential of Mesenchymal Precursor Cells under the Effect of Fibroblast Growth Factor .
26608375	0	p53	31,34	JNK	8,11	p53	JNK	7157	5599	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of JNK and Involvement of p53 in Stimulation of Growth Potential Realization of Mesenchymal Precursor Cells by Alkaloid_Songorine .
9732264	0	p53	12,15	JNK	0,3	p53	JNK	7157	5599	Gene	Gene	ubiquitination|compound|START_ENTITY targets|dobj|ubiquitination targets|nsubj|END_ENTITY	JNK targets p53 ubiquitination and degradation in nonstressed cells .
12534344	0	p53	113,116	JNK1	38,42	p53	JNK1	7157	5599	Gene	Gene	stabilization|nmod|START_ENTITY END_ENTITY|nmod|stabilization	A role for c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- , but not JNK2 , in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons .
15778501	0	p53	34,37	JNK1	0,4	p53	JNK1	7157	5599	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix : JNK links FAK and p53 .
26334721	0	p53	34,37	Jmjd5	0,5	p53	Jmjd5	22059(Tax:10090)	77035(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY functions|nmod|regulator functions|amod|END_ENTITY	Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis .
26756900	0	p53	54,57	Jnk	106,109	p53	Jnk	7157	5599	Gene	Gene	accumulation|compound|START_ENTITY suppresses|dobj|accumulation suppresses|nmod|inhibition inhibition|nmod|activation activation|compound|END_ENTITY	COX-2 inhibitor NS-398 suppresses doxorubicin-induced p53 accumulation through inhibition of ROS-mediated Jnk activation .
12809946	0	p53	53,56	Jun_N-terminal_kinase	0,21	p53	Jun N-terminal kinase	301300(Tax:10116)	116554(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Jun_N-terminal_kinase activation and upregulation of p53 and p21 -LRB- WAF1/CIP1 -RRB- in selenite-induced apoptosis of regenerating liver .
11283254	0	p53	43,46	Jun_NH2-terminal_kinase	0,23	p53	Jun NH2-terminal kinase	7157	5599	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Jun_NH2-terminal_kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress .
11283254	0	p53	74,77	Jun_NH2-terminal_kinase	0,23	p53	Jun NH2-terminal kinase	7157	5599	Gene	Gene	stabilization|nummod|START_ENTITY important|nmod|stabilization important|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Jun_NH2-terminal_kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress .
19107228	0	p53	69,72	K-Ras	53,58	p53	K-Ras	7157	3845	Gene	Gene	expression|compound|START_ENTITY recovers|dobj|expression recovers|nsubj|Blocking Blocking|acl|promoted promoted|nmod|END_ENTITY	Blocking of p53-Snail binding , promoted by oncogenic K-Ras , recovers p53 expression and function .
24344114	0	p53	14,17	K-Ras	37,42	p53	K-Ras	7157	3845	Gene	Gene	re-enters|compound|START_ENTITY END_ENTITY|nsubj|re-enters	Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system .
10353750	0	p53	26,29	K-ras	157,162	p53	K-ras	7157	3845	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene Detection|nmod|mutations Detection|dep|comparison comparison|nmod|mutation mutation|compound|END_ENTITY	Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic_cancer : comparison with K-ras mutation .
11836595	0	p53	18,21	K-ras	52,57	p53	K-ras	7157	3845	Gene	Gene	protein|compound|START_ENTITY protein|nmod|genes genes|compound|END_ENTITY	Overexpression of p53 protein and point mutation of K-ras genes in primary_carcinoma of the small intestine .
12374683	0	p53	16,19	K-ras	0,5	p53	K-ras	7157	3845	Gene	Gene	overexpression|compound|START_ENTITY mutation|appos|overexpression mutation|amod|END_ENTITY	K-ras mutation , p53 overexpression , and microsatellite_instability in biliary_tract_cancers : a population-based study in China .
12763212	0	p53	34,37	K-ras	27,32	p53	K-ras	7157	3845	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
12911661	0	p53	0,3	K-ras	16,21	p53	K-ras	7157	3845	Gene	Gene	expression|compound|START_ENTITY expression|appos|mutation mutation|compound|END_ENTITY	p53 expression , K-ras gene mutation and microsatellite_instability in gastric_B-cell_lymphomas .
15824025	0	p53	36,39	K-ras	0,5	p53	K-ras	22060(Tax:10090)	16653(Tax:10090)	Gene	Gene	mice|nummod|START_ENTITY lung_tumors|nmod|mice mutations|nmod|lung_tumors mutations|amod|END_ENTITY	K-ras mutations in lung_tumors from p53 mutant mice exposed to cigarette smoke .
18283039	0	p53	85,88	K-ras	79,84	p53	K-ras	22060(Tax:10090)	16653(Tax:10090)	Gene	Gene	model|compound|START_ENTITY model|compound|END_ENTITY	Telomere_dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung_cancer .
21528323	0	p53	19,22	K-ras	12,17	p53	K-ras	7157	3845	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of K-ras , p53 , bcl-2 and Rb expression in non-small_cell_lung_cancer cell lines .
21952947	0	p53	24,27	K-ras	116,121	p53	K-ras	7157	3845	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Gain-of-function mutant p53 but not p53 deletion promotes head_and_neck_cancer progression in response to oncogenic K-ras .
23168708	0	p53	12,15	K-ras	17,22	p53	K-ras	7157	3845	Gene	Gene	START_ENTITY|appos|Helicobacter_pylori_infection Helicobacter_pylori_infection|compound|END_ENTITY	Analysis of p53 , K-ras gene mutation _ Helicobacter_pylori_infection in patients with gastric_cancer _ peptic_ulcer_disease at a tertiary care hospital in north India .
24038521	0	p53	8,11	K-ras	28,33	p53	K-ras	7157	3845	Gene	Gene	cooperates|compound|START_ENTITY cooperates|nmod|END_ENTITY	Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner .
25857071	0	p53	18,21	K-ras	11,16	p53	K-ras	7157	3845	Gene	Gene	DPC4|compound|START_ENTITY END_ENTITY|dep|DPC4	-LSB- Oncogene -LRB- K-ras , p53 , p16 , DPC4 , hTERTmRNA -RRB- -RSB- .
7586136	0	p53	26,29	K-ras	57,62	p53	K-ras	22060(Tax:10090)	16653(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene mutations|dep|mutations mutations|compound|END_ENTITY	Frequent mutations of the p53 gene and infrequent H - and K-ras mutations in urinary_bladder_carcinomas of NON/Shi mice treated with N-butyl-N - -LRB- 4-hydroxybutyl -RRB- nitrosamine .
7835585	0	p53	60,63	K-ras	28,33	p53	K-ras	7157	3845	Gene	Gene	accumulation|compound|START_ENTITY activation|nmod|accumulation END_ENTITY|dep|activation	Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant_crypt_foci of the colon .
7852189	0	p53	18,21	K-ras	68,73	p53	K-ras	7157	3845	Gene	Gene	gene|compound|START_ENTITY Alteration|nmod|gene occurs|nsubj|Alteration occurs|nmod|activation activation|compound|END_ENTITY	Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial_tumors of the human ovary .
7914949	0	p53	79,82	K-ras	41,46	p53	K-ras	7157	3845	Gene	Gene	protein|compound|START_ENTITY overexpression|nmod|protein mutation|appos|overexpression mutation|compound|END_ENTITY	Prognostic factors of colorectal_cancer : K-ras mutation , overexpression of the p53 protein , and cell proliferative activity .
8121190	0	p53	40,43	K-ras	9,14	p53	K-ras	7157	3845	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|mutations END_ENTITY|dep|mutations	Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas .
9230291	0	p53	103,106	K-ras	21,26	p53	K-ras	22060(Tax:10090)	16653(Tax:10090)	Gene	Gene	transgene|compound|START_ENTITY carrying|dobj|transgene incidence|acl|carrying incidence|nmod|mutations mutations|compound|END_ENTITY	Similar incidence of K-ras mutations in lung_carcinomas of FVB/N _ mice and FVB/N _ mice carrying a mutant p53 transgene .
9402497	0	p53	66,69	K-ras	78,83	p53	K-ras	7157	3845	Gene	Gene	expressing|dobj|START_ENTITY expressing|nmod|mutation mutation|compound|END_ENTITY	Carcinoma_of_the_colon in childhood ; report of 2 cases expressing p53 without K-ras mutation .
24120139	0	p53	14,17	KIT_ligand	38,48	p53	KIT ligand	7157	4254	Gene	Gene	element|compound|START_ENTITY element|nmod|END_ENTITY	A polymorphic p53 response element in KIT_ligand influences cancer risk and has undergone natural selection .
16595680	0	p53	20,23	KLF5	0,4	p53	KLF5	7157	688	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|nsubj|END_ENTITY	KLF5 Interacts with p53 in regulating survivin expression in acute_lymphoblastic_leukemia .
21868761	0	p53	52,55	KLF5	29,33	p53	KLF5	7157	688	Gene	Gene	ablation|compound|START_ENTITY context|nmod|ablation END_ENTITY|nmod|context	Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous_cell_cancer .
22990386	0	p53	0,3	KLF5	66,70	p53	KLF5	7157	688	Gene	Gene	mutation|compound|START_ENTITY alters|nsubj|mutation alters|dobj|effect effect|nmod|END_ENTITY	p53 mutation alters the effect of the esophageal_tumor suppressor KLF5 on keratinocyte proliferation .
22253232	0	p53	22,25	KR-POK	0,6	p53	KR-POK	22060(Tax:10090)	207259(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A .
26747697	0	p53	0,3	Keratin_17	46,56	p53	Keratin 17	301300(Tax:10116)	287702(Tax:10116)	Gene	Gene	Repressor|nsubj|START_ENTITY Repressor|nmod|END_ENTITY	p53 Is a Direct Transcriptional Repressor of Keratin_17 : Lessons from a Rat Model of Radiation Dermatitis .
24058630	0	p53	52,55	Kras	27,31	p53	Kras	22060(Tax:10090)	16653(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial_hyperplasia .
15314173	0	p53	32,35	L23	18,21	p53	L23	7157	9349	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition .
18046411	0	p53	0,3	LIF	44,47	p53	LIF	22060(Tax:10090)	16878(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p53 regulates maternal reproduction through LIF .
19907922	0	p53	0,3	LIF	14,17	p53	LIF	7157	3976	Gene	Gene	Regulates|compound|START_ENTITY END_ENTITY|nsubj|Regulates	p53 Regulates LIF expression in human medulloblastoma cells .
25323535	0	p53	43,46	LIF	0,3	p53	LIF	7157	3976	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal_cancers .
26161442	0	p53	13,16	LIF	0,3	p53	LIF	7157	3976	Gene	Gene	regulator|compound|START_ENTITY regulator|nsubj|END_ENTITY	LIF is a new p53 negative regulator .
17108107	0	p53	46,49	LKB1	0,4	p53	LKB1	7157	6794	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation .
20368693	0	p53	64,67	LKB1	11,15	p53	LKB1	7157	6794	Gene	Gene	pathways|compound|START_ENTITY /|nmod|pathways /|nsubj|G G|compound|END_ENTITY	Endogenous LKB1 knockdown accelerates G -LRB- 1 -RRB- / S transition through p53 and p16 pathways .
21411391	0	p53	107,110	LKB1	28,32	p53	LKB1	7157	6794	Gene	Gene	activity|compound|START_ENTITY diminished|dobj|activity diminished|nsubj|mutation mutation|nmod|gene gene|nummod|END_ENTITY	A novel de novo mutation in LKB1 gene in a Chinese Peutz_Jeghers_syndrome patient significantly diminished p53 activity .
23995788	0	p53	38,41	LKB1	0,4	p53	LKB1	7157	6794	Gene	Gene	promotes|nsubj|START_ENTITY loss|parataxis|promotes loss|nummod|END_ENTITY	LKB1 loss by alteration of the NKX2-1 / p53 pathway promotes tumor malignancy and predicts poor survival and relapse in lung_adenocarcinomas .
25042259	0	p53	92,95	LKB1	50,54	p53	LKB1	7157	6794	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Loss of LKB1 in high-grade endometrial_carcinoma : LKB1 is a novel transcriptional target of p53 .
25042259	0	p53	92,95	LKB1	8,12	p53	LKB1	7157	6794	Gene	Gene	target|nmod|START_ENTITY Loss|parataxis|target Loss|nmod|END_ENTITY	Loss of LKB1 in high-grade endometrial_carcinoma : LKB1 is a novel transcriptional target of p53 .
19995558	0	p53	20,23	LMO3	0,4	p53	LMO3	7157	55885	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LMO3 interacts with p53 and inhibits its transcriptional activity .
22185663	0	p53	56,59	LMP1	43,47	p53	LMP1	7157	9260	Gene	Gene	levels|compound|START_ENTITY reduces|iobj|levels reduces|nsubj|END_ENTITY	Epstein-Barr_virus Latent Membrane Protein LMP1 reduces p53 protein levels independent of the PI3K-Akt pathway .
22266808	0	p53	70,73	LMP1	31,35	p53	LMP1	7157	9260	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Epstein-Barr_virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal_carcinoma .
22684299	0	p53	124,127	LMP1	18,22	p53	LMP1	7157	9260	Gene	Gene	ubiquitination|nmod|START_ENTITY modulating|dobj|ubiquitination disrupts|advcl|modulating disrupts|nsubj|END_ENTITY	Viral oncoprotein LMP1 disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53 .
7912753	0	p53	49,52	LOH	37,40	p53	p53	7157	7157	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	-LSB- Analysis of loss of heterozygosity -LRB- LOH -RRB- at the p53 and Rb suppressor genes in urinary_bladder_carcinoma -RSB- .
17805299	0	p53	0,3	LSD1	43,47	p53	LSD1	7157	23028	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	p53 is regulated by the lysine demethylase LSD1 .
23072722	0	p53	123,126	LSD1	8,12	p53	LSD1	7157	23028	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells suppresses|dobj|expression suppresses|nsubj|Loss Loss|nmod|END_ENTITY	Loss of LSD1 -LRB- lysine-specific_demethylase_1 -RRB- suppresses growth and alters gene expression of human colon_cancer cells in a p53 - and DNMT1 -LRB- DNA_methyltransferase_1 -RRB- - independent manner .
26384650	0	p53	52,55	Leucine-Rich_Repeat_Kinase_2	0,28	p53	Leucine-Rich Repeat Kinase 2	7157	120892	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Leucine-Rich_Repeat_Kinase_2 -LRB- LRRK2 -RRB- phosphorylates p53 and induces p21 -LRB- WAF1/CIP1 -RRB- expression .
16278673	0	p53	83,86	Lkb1	76,80	p53	Lkb1	22060(Tax:10090)	20869(Tax:10090)	Gene	Gene	/|dep|START_ENTITY onsets|parataxis|/ onsets|dep|carcinomas carcinomas|nmod|+ +|amod|END_ENTITY	Accelerated onsets of gastric_hamartomas and hepatic_adenomas / carcinomas in Lkb1 + / - p53 - / - compound mutant mice .
22055193	0	p53	13,16	Lpin1	30,35	p53	Lpin1	22060(Tax:10090)	14245(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	ROS-mediated p53 induction of Lpin1 regulates fatty_acid oxidation in response to nutritional stress .
17317671	0	p53	41,44	MAML1	20,25	p53	MAML1	7157	9794	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The notch regulator MAML1 interacts with p53 and functions as a coactivator .
26033683	0	p53	0,3	MAML1	117,122	p53	MAML1	7157	9794	Gene	Gene	Modulates|nsubj|START_ENTITY Modulates|advcl|Associating Associating|nmod|END_ENTITY	p53 Modulates Notch Signaling in MCF-7 Breast_Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1 .
10891498	0	p53	15,18	MCG10	0,5	p53	MCG10	7157	57060	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	MCG10 , a novel p53 target gene that encodes a KH domain RNA-binding protein , is capable of inducing apoptosis and cell cycle arrest in G -LRB- 2 -RRB- - M. p53 , a tumor suppressor , inhibits cell proliferation by inducing cellular genes involved in the regulation of the cell cycle .
9464547	0	p53	62,65	MCK	46,49	p53	MCK	7157	1158	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Synergistic transcriptional activation of the MCK promoter by p53 : tetramers link separated DNA response elements by DNA looping .
7619220	0	p53	49,52	MDM-2	18,23	p53	MDM-2	7157	4193	Gene	Gene	gene|compound|START_ENTITY Overexpression|nmod|gene Overexpression|nmod|mRNA mRNA|compound|END_ENTITY	Overexpression of MDM-2 mRNA and mutation of the p53 tumor suppressor gene in bladder_carcinoma cell lines .
8297484	0	p53	83,86	MDM-2	11,16	p53	MDM-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	status|compound|START_ENTITY amplification|nmod|status amplification|nsubj|Absence Absence|nmod|gene gene|compound|END_ENTITY	Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status .
9267820	0	p53	98,101	MDM-2	0,5	p53	MDM-2	7157	4193	Gene	Gene	accumulation|compound|START_ENTITY association|nmod|accumulation overexpression|dep|association overexpression|compound|END_ENTITY	MDM-2 oncoprotein overexpression in laryngeal_squamous_cell_carcinoma : association with wild-type p53 accumulation .
10072445	0	p53	24,27	MDM2	70,74	p53	MDM2	7157	4193	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression .
10086736	0	p53	19,22	MDM2	47,51	p53	MDM2	7157	4193	Gene	Gene	p53|compound|START_ENTITY Aberrations|nmod|p53 appear|ccomp|Aberrations appear|nsubj|END_ENTITY	Aberrations of the p53 pathway components p53 , MDM2 and CDKN2A appear independent in diffuse large B_cell_lymphoma .
10086736	0	p53	42,45	MDM2	47,51	p53	MDM2	7157	4193	Gene	Gene	Aberrations|nmod|START_ENTITY appear|ccomp|Aberrations appear|nsubj|END_ENTITY	Aberrations of the p53 pathway components p53 , MDM2 and CDKN2A appear independent in diffuse large B_cell_lymphoma .
10208414	0	p53	0,3	MDM2	43,47	p53	MDM2	7157	4193	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|death death|nmod|cells cells|acl|overexpressing overexpressing|dobj|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10208414	0	p53	0,3	MDM2	67,71	p53	MDM2	7157	4193	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|death death|nmod|cells cells|acl|overexpressing overexpressing|nmod|inhibitor inhibitor|nmod|interaction interaction|nummod|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10208414	0	p53	89,92	MDM2	43,47	p53	MDM2	7157	4193	Gene	Gene	interaction|nmod|START_ENTITY inhibitor|nmod|interaction overexpressing|nmod|inhibitor overexpressing|dobj|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10208414	0	p53	89,92	MDM2	67,71	p53	MDM2	7157	4193	Gene	Gene	interaction|nmod|START_ENTITY interaction|nummod|END_ENTITY	p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53 .
10347217	0	p53	32,35	MDM2	71,75	p53	MDM2	7157	4193	Gene	Gene	required|nmod|START_ENTITY required|xcomp|be be|advmod|efficiently efficiently|dep|ubiquitinated ubiquitinated|nmod|END_ENTITY	Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2 .
10611293	0	p53	37,40	MDM2	80,84	p53	MDM2	7157	4193	Gene	Gene	motif|nmod|START_ENTITY motif|dep|interaction interaction|nmod|END_ENTITY	The alpha-helical FXXPhiPhi motif in p53 : TAF interaction and discrimination by MDM2 .
10611322	0	p53	53,56	MDM2	39,43	p53	MDM2	7157	4193	Gene	Gene	accumulation|compound|START_ENTITY precedes|dobj|accumulation precedes|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage .
10626788	0	p53	16,19	MDM2	41,45	p53	MDM2	7157	4193	Gene	Gene	accumulation|compound|START_ENTITY induces|dobj|accumulation induces|nmod|down-regulation down-regulation|compound|END_ENTITY	Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation .
10645001	0	p53	21,24	MDM2	56,60	p53	MDM2	7157	4193	Gene	Gene	exclusion|nmod|START_ENTITY requires|nsubj|exclusion requires|dobj|function function|compound|END_ENTITY	Nuclear exclusion of p53 in a subset of tumors requires MDM2 function .
10681559	0	p53	59,62	MDM2	38,42	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	destabilize|dobj|START_ENTITY p90|acl|destabilize p90|appos|END_ENTITY	p76 -LRB- MDM2 -RRB- inhibits the ability of p90 -LRB- MDM2 -RRB- to destabilize p53 .
10681559	0	p53	59,62	MDM2	4,8	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	destabilize|dobj|START_ENTITY p90|acl|destabilize ability|nmod|p90 inhibits|dobj|ability inhibits|nsubj|p76 p76|appos|END_ENTITY	p76 -LRB- MDM2 -RRB- inhibits the ability of p90 -LRB- MDM2 -RRB- to destabilize p53 .
10688649	0	p53	4,7	MDM2	84,88	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	protein|nummod|START_ENTITY regulate|nsubj|protein regulate|dobj|expression expression|nmod|inhibitor inhibitor|appos|END_ENTITY	The p53 tumor suppressor protein does not regulate expression of its own inhibitor , MDM2 , except under conditions of stress .
10721693	0	p53	30,33	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	protein|compound|START_ENTITY regulator|nmod|protein END_ENTITY|dep|regulator	MDM2 -- master regulator of the p53 tumor suppressor protein .
10830726	0	p53	40,43	MDM2	137,141	p53	MDM2	7157	4193	Gene	Gene	derivative|compound|START_ENTITY CTS1|appos|derivative mediated|nmod|CTS1 mediated|xcomp|overexpressing overexpressing|dobj|END_ENTITY	Cancer gene therapy mediated by CTS1 , a p53 derivative : advantage over wild-type p53 in growth inhibition of human tumors overexpressing MDM2 .
10830726	0	p53	81,84	MDM2	137,141	p53	MDM2	7157	4193	Gene	Gene	advantage|nmod|START_ENTITY derivative|dep|advantage CTS1|appos|derivative mediated|nmod|CTS1 mediated|xcomp|overexpressing overexpressing|dobj|END_ENTITY	Cancer gene therapy mediated by CTS1 , a p53 derivative : advantage over wild-type p53 in growth inhibition of human tumors overexpressing MDM2 .
10835493	0	p53	43,46	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	protein|compound|START_ENTITY alteration|nmod|protein overexpression|nmod|alteration overexpression|nsubj|END_ENTITY	MDM2 overexpression with alteration of the p53 protein and gene status in oral carcinogenesis .
10845931	0	p53	0,3	MDM2	113,117	p53	MDM2	7157	4193	Gene	Gene	stabilization|compound|START_ENTITY stabilization|dep|loop loop|compound|END_ENTITY	p53 stabilization and functional impairment in the absence of genetic mutation or the alteration of the p14 -LRB- ARF -RRB- - MDM2 loop in ex vivo and cultured adult_T-cell_leukemia / lymphoma cells .
10914734	0	p53	132,135	MDM2	166,170	p53	MDM2	7157	4193	Gene	Gene	accumulation|compound|START_ENTITY accumulation|nmod|down-regulation down-regulation|compound|END_ENTITY	Induction of apoptosis in human esophageal_cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes : involvement of p53 accumulation via ARF-mediated MDM2 down-regulation .
10914734	0	p53	96,99	MDM2	166,170	p53	MDM2	7157	4193	Gene	Gene	transfer|nmod|START_ENTITY cells|nmod|transfer apoptosis|nmod|cells Induction|nmod|apoptosis Induction|dep|involvement involvement|nmod|accumulation accumulation|nmod|down-regulation down-regulation|compound|END_ENTITY	Induction of apoptosis in human esophageal_cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes : involvement of p53 accumulation via ARF-mediated MDM2 down-regulation .
10949923	0	p53	12,15	MDM2	19,23	p53	MDM2	7157	4193	Gene	Gene	Switch|nmod|START_ENTITY Switch|nmod|END_ENTITY	Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size .
10963376	0	p53	85,88	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	overexpression|compound|START_ENTITY relationship|nmod|overexpression Overexpression|dep|relationship Overexpression|nmod|protein protein|nummod|END_ENTITY	Overexpression of MDM2 protein in intrahepatic_cholangiocarcinoma : relationship with p53 overexpression , Ki-67 labeling , and clinicopathological features .
10980696	0	p53	51,54	MDM2	4,8	p53	MDM2	7157	4193	Gene	Gene	export|nummod|START_ENTITY promote|dobj|export required|xcomp|promote required|nsubjpass|domain domain|compound|END_ENTITY	The MDM2 RING-finger domain is required to promote p53 nuclear export .
11012984	0	p53	106,109	MDM2	60,64	p53	MDM2	7157	4193	Gene	Gene	overexpression|compound|START_ENTITY correlates|nmod|overexpression correlates|nsubj|inactivation inactivation|nmod|concomitant concomitant|nmod|overexpression overexpression|compound|END_ENTITY	Immunohistochemical inactivation of p14ARF concomitant with MDM2 overexpression inversely correlates with p53 overexpression in oral_squamous_cell_carcinoma .
11070080	0	p53	28,31	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	acetylation|compound|START_ENTITY inhibits|dobj|acetylation inhibits|nsubj|END_ENTITY	MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins .
11091516	0	p53	81,84	MDM2	27,31	p53	MDM2	7157	4193	Gene	Gene	Alterations|compound|START_ENTITY Breast_Cancers|nmod|Alterations Amplification|nmod|Breast_Cancers Amplification|nmod|Gene Gene|compound|END_ENTITY	Low Grade Amplification of MDM2 Gene in a Subset of Human Breast_Cancers without p53 Alterations .
11125034	0	p53	35,38	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	exclusion|nmod|START_ENTITY attenuates|nsubj|exclusion mediated|ccomp|attenuates mediated|nsubj|END_ENTITY	MDM2 mediated nuclear exclusion of p53 attenuates etoposide-induced apoptosis in neuroblastoma cells .
11152666	0	p53	48,51	MDM2	21,25	p53	MDM2	7157	4193	Gene	Gene	oncoprotein|nmod|START_ENTITY oncoprotein|nsubj|Stabilization Stabilization|nmod|END_ENTITY	Stabilization of the MDM2 oncoprotein by mutant p53 .
11223035	0	p53	34,37	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents .
11223035	0	p53	52,55	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY inhibiting|dobj|ubiquitination stabilizes|advcl|inhibiting stabilizes|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents .
11245471	0	p53	44,47	MDM2	62,66	p53	MDM2	7157	4193	Gene	Gene	modulation|nmod|START_ENTITY p73|nmod|modulation role|nmod|p73 level|nsubj|role level|nmod|END_ENTITY	A possible role of p73 on the modulation of p53 level through MDM2 .
11313871	0	p53	49,52	MDM2	41,45	p53	MDM2	7157	4193	Gene	Gene	stability|compound|START_ENTITY contribution|nmod|stability contribution|nmod|domain domain|nmod|END_ENTITY	The contribution of the acidic domain of MDM2 to p53 and MDM2 stability .
11331246	0	p53	11,14	MDM2	52,56	p53	MDM2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY Control|nmod|ubiquitination Control|nmod|END_ENTITY	Control of p53 ubiquitination and nuclear export by MDM2 and ARF .
11331871	0	p53	17,20	MDM2	53,57	p53	MDM2	7157	4193	Gene	Gene	Stabilization|nmod|START_ENTITY Stabilization|nmod|p14ARF p14ARF|nmod|relocation relocation|nmod|END_ENTITY	Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus .
11423970	0	p53	14,17	MDM2	57,61	p53	MDM2	7157	4193	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|compound|END_ENTITY	Activation of p53 by roscovitine-mediated suppression of MDM2 expression .
11485818	0	p53	19,22	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	life|nmod|START_ENTITY END_ENTITY|dep|life	MDM2 : life without p53 .
11505267	0	p53	12,15	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	oral_liposarcoma|compound|START_ENTITY CDK4|dep|oral_liposarcoma +|dep|CDK4 +|compound|END_ENTITY	MDM2 + / CDK4 + / p53 + oral_liposarcoma : case report and review of the literature .
11507088	0	p53	50,53	MDM2	14,18	p53	MDM2	7157	4193	Gene	Gene	stabilization|compound|START_ENTITY contributes|nmod|stabilization contributes|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization .
11528400	0	p53	121,124	MDM2	104,108	p53	MDM2	22059(Tax:10090)	17246(Tax:10090)	Gene	Gene	regulate|dobj|START_ENTITY pathway|acl|regulate pathway|nmod|END_ENTITY	Rescue of embryonic_lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 .
11559539	0	p53	28,31	MDM2	72,76	p53	MDM2	7157	4193	Gene	Gene	distribution|nmod|START_ENTITY regulated|nsubjpass|distribution regulated|nmod|END_ENTITY	Subcellular distribution of p53 and p73 are differentially regulated by MDM2 .
11692147	0	p53	88,91	MDM2	15,19	p53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY relationship|nmod|status Alterations|dep|relationship Alterations|nmod|expression expression|nummod|END_ENTITY	Alterations in MDM2 expression in esophageal_squamous_cell_carcinoma : relationship with p53 status .
11715018	0	p53	18,21	MDM2	54,58	p53	MDM2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY ubiquitination|nmod|phosphorylation phosphorylation|compound|END_ENTITY	HER-2 / neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation .
11753042	0	p53	95,98	MDM2	100,104	p53	MDM2	7157	4193	Gene	Gene	p16INK4a|appos|START_ENTITY p16INK4a|appos|END_ENTITY	p16INK4a is a prognostic marker in resected_ductal_pancreatic_cancer : an analysis of p16INK4a , p53 , MDM2 , an Rb .
11820589	0	p53	0,3	MDM2	5,9	p53	MDM2	7157	4193	Gene	Gene	staining|compound|START_ENTITY staining|dep|END_ENTITY	p53 , MDM2 , bcl-2 staining in follicular_neoplasms of the thyroid gland .
11925449	0	p53	155,158	MDM2	94,98	p53	MDM2	7157	4193	Gene	Gene	ubiquitination|nmod|START_ENTITY increases|dobj|ubiquitination site|acl:relcl|increases site|compound|END_ENTITY	The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo .
11925449	0	p53	73,76	MDM2	94,98	p53	MDM2	7157	4193	Gene	Gene	domain|nmod|START_ENTITY region|nmod|domain contains|nsubj|region contains|dobj|site site|compound|END_ENTITY	The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo .
11953423	0	p53	71,74	MDM2	21,25	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	dependence|nmod|START_ENTITY dependence|nmod|END_ENTITY	Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 .
11971195	0	p53	47,50	MDM2	96,100	p53	MDM2	7157	4193	Gene	Gene	C-terminus|nmod|START_ENTITY mutations|nmod|C-terminus make|nsubj|mutations make|xcomp|resistant resistant|nmod|degradation degradation|acl|mediated mediated|nmod|END_ENTITY	Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human_papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells .
12027449	0	p53	0,3	MDM2	134,138	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	p51|nummod|START_ENTITY p51|dep|p51B p51B|acl:relcl|occurs occurs|advcl|forming forming|nmod|END_ENTITY	p53 gene family p51 -LRB- p63 -RRB- - encoded , secondary transactivator p51B -LRB- TAp63alpha -RRB- occurs without forming an immunoprecipitable complex with MDM2 , but responds to genotoxic stress by accumulation .
12068014	0	p53	74,77	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	PCAF|dep|START_ENTITY PCAF|compound|END_ENTITY	MDM2 inhibits PCAF -LRB- p300/CREB-binding protein-associated factor -RRB- - mediated p53 acetylation .
12208736	0	p53	51,54	MDM2	94,98	p53	MDM2	7157	4193	Gene	Gene	stabilize|dobj|START_ENTITY stabilize|advcl|disrupting disrupting|nmod|END_ENTITY	The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 .
12208736	0	p53	87,90	MDM2	94,98	p53	MDM2	7157	4193	Gene	Gene	regulation|nmod|START_ENTITY disrupting|dobj|regulation disrupting|nmod|END_ENTITY	The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2 .
12536604	0	p53	36,39	MDM2	45,49	p53	MDM2	7157	4193	Gene	Gene	START_ENTITY|nmod|overexpression overexpression|nummod|END_ENTITY	-LSB- Role of functional inactivation of p53 from MDM2 overexpression in hepatocarcinogenesis -RSB- .
12832479	0	p53	51,54	MDM2	29,33	p53	MDM2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY contribution|nmod|ubiquitination contribution|nmod|domain domain|compound|END_ENTITY	Critical contribution of the MDM2 acidic domain to p53 ubiquitination .
14507915	0	p53	92,95	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	interaction|nmod|START_ENTITY antagonize|nmod|interaction antagonize|nsubj|END_ENTITY	MDM2 and promyelocytic_leukemia antagonize each other through their direct interaction with p53 .
14704432	0	p53	26,29	MDM2	71,75	p53	MDM2	7157	4193	Gene	Gene	activation|nmod|START_ENTITY pathway|nsubj|activation pathway|nmod|antagonists antagonists|nmod|END_ENTITY	In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 .
14761977	0	p53	61,64	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	independent|nmod|START_ENTITY p21WAF1/CIP1|appos|independent regulator|nmod|p21WAF1/CIP1 regulator|nsubj|END_ENTITY	MDM2 is a negative regulator of p21WAF1/CIP1 , independent of p53 .
15029243	0	p53	80,83	MDM2	12,16	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|auto-degradation auto-degradation|compound|END_ENTITY	Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation .
15064742	0	p53	54,57	MDM2	31,35	p53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY role|nmod|pathway role|nmod|END_ENTITY	A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway .
15094782	0	p53	24,27	MDM2	101,105	p53	MDM2	7157	4193	Gene	Gene	inhibition|compound|START_ENTITY accumulation|nmod|inhibition due|nsubj|accumulation due|nmod|levels levels|nmod|END_ENTITY	Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2 .
15122315	0	p53	43,46	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	activity|compound|START_ENTITY rescuing|dobj|activity inhibition|acl|rescuing inhibition|nummod|END_ENTITY	HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function .
15314173	0	p53	32,35	MDM2	50,54	p53	MDM2	7157	4193	Gene	Gene	activates|dobj|START_ENTITY activates|advcl|inhibiting inhibiting|dobj|function function|nummod|END_ENTITY	Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition .
15358376	0	p53	34,37	MDM2	29,33	p53	MDM2	7157	4193	Gene	Gene	domain|compound|START_ENTITY domain|compound|END_ENTITY	Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide .
15358376	0	p53	68,71	MDM2	29,33	p53	MDM2	7157	4193	Gene	Gene	transactivation|compound|START_ENTITY fusion|nmod|transactivation domain|nmod|fusion domain|compound|END_ENTITY	Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide .
15364927	0	p53	23,26	MDM2	68,72	p53	MDM2	7157	4193	Gene	Gene	functions|compound|START_ENTITY regulation|nmod|functions regulation|nmod|END_ENTITY	Negative regulation of p53 functions by Daxx and the involvement of MDM2 .
15371552	0	p53	42,45	MDM2	19,23	p53	MDM2	7157	4193	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA -LRB- peptide nucleic acid -RRB- conjugates .
15550242	0	p53	69,72	MDM2	40,44	p53	MDM2	7157	4193	Gene	Gene	suppressor|compound|START_ENTITY attenuates|dobj|suppressor attenuates|nsubj|polymorphism polymorphism|nmod|promoter promoter|compound|END_ENTITY	A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans .
15600307	0	p53	22,25	MDM2	53,57	p53	MDM2	7157	4193	Gene	Gene	Use|nmod|START_ENTITY peptide|nsubj|Use peptide|nmod|inhibitor inhibitor|nmod|END_ENTITY	Use of a retroinverso p53 peptide as an inhibitor of MDM2 .
15610030	0	p53	131,134	MDM2	111,115	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	turnover|compound|START_ENTITY regulate|dobj|turnover sites|acl:relcl|regulate sites|appos|END_ENTITY	Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine_double-minute_clone_2_protein -LRB- MDM2 -RRB- that regulate p53 turnover .
15656374	0	p53	19,22	MDM2	24,28	p53	MDM2	301300(Tax:10116)	314856(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression treated|advcl|-LSB- treated|nsubj|gene gene|compound|END_ENTITY	-LSB- The expression of p53 , MDM2 and Ref1 gene in cultured retina neurons of SD rats treated with vitamin_B1 and/or elevated pressure -RSB- .
15684615	0	p53	88,91	MDM2	51,55	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|twist twist|nmod|loop loop|dep|destabilization destabilization|compound|END_ENTITY	A new twist in the feedback loop : stress-activated MDM2 destabilization is required for p53 activation .
15720184	0	p53	30,33	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY node|nmod|pathway node|nsubj|END_ENTITY	MDM2 is a central node in the p53 pathway : 12 years and counting .
15753391	0	p53	14,17	MDM2	21,25	p53	MDM2	7157	4193	Gene	Gene	START_ENTITY|nmod|antagonists antagonists|nummod|END_ENTITY	Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors .
16107876	0	p53	62,65	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	inactivation|compound|START_ENTITY contributes|nmod|inactivation contributes|nsubj|interaction interaction|nummod|END_ENTITY	MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation .
16202543	0	p53	28,31	MDM2	81,85	p53	MDM2	7157	4193	Gene	Gene	Characterisation|nmod|START_ENTITY down-regulated|nsubj|Characterisation down-regulated|nmod|intron intron|nmod|oncogene oncogene|compound|END_ENTITY	Characterisation of a novel p53 down-regulated promoter in intron 3 of the human MDM2 oncogene .
16443686	0	p53	48,51	MDM2	15,19	p53	MDM2	7157	4193	Gene	Gene	reveal|dobj|START_ENTITY reveal|nsubj|antagonists antagonists|compound|END_ENTITY	Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer : implications for therapy .
16789731	0	p53	78,81	MDM2	72,76	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY Discovery|dep|interaction Discovery|nmod|inhibitor inhibitor|nmod|murine_double_minute_2 murine_double_minute_2|appos|END_ENTITY	Discovery of a nanomolar inhibitor of the human murine_double_minute_2 -LRB- MDM2 -RRB- - p53 interaction through an integrated , virtual database screening strategy .
16861890	0	p53	51,54	MDM2	104,108	p53	MDM2	7157	4193	Gene	Gene	polyubiquitination|compound|START_ENTITY polyubiquitination|nmod|complexes complexes|compound|END_ENTITY	L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes .
16905541	0	p53	29,32	MDM2	51,55	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY prevents|dobj|activation prevents|nmod|Nutlin Nutlin|compound|END_ENTITY	MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin .
16925398	0	p53	38,41	MDM2	74,78	p53	MDM2	7157	4193	Gene	Gene	analogue|compound|START_ENTITY analysis|nmod|analogue complexed|nsubj|analysis complexed|nmod|END_ENTITY	Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2 .
17002294	0	p53	124,127	MDM2	31,35	p53	MDM2	7157	4193	Gene	Gene	motif|nmod|START_ENTITY disrupts|dep|motif Determinants|dep|disrupts Determinants|nmod|specificity specificity|nmod|END_ENTITY	Determinants of specificity of MDM2 for the activation_domains of p53 and p65 : proline27 disrupts the MDM2-binding motif of p53 .
17002294	0	p53	66,69	MDM2	31,35	p53	MDM2	7157	4193	Gene	Gene	activation_domains|nmod|START_ENTITY END_ENTITY|nmod|activation_domains	Determinants of specificity of MDM2 for the activation_domains of p53 and p65 : proline27 disrupts the MDM2-binding motif of p53 .
17139261	0	p53	0,3	MDM2	40,44	p53	MDM2	7157	4193	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|regulation regulation|nmod|END_ENTITY	p53 mediates the negative regulation of MDM2 by orphan receptor TR3 .
17339337	0	p53	60,63	MDM2	4,8	p53	MDM2	7157	4193	Gene	Gene	domain|nmod|START_ENTITY signal|nmod|domain signal|compound|END_ENTITY	The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members .
17363365	0	p53	48,51	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|binding binding|compound|END_ENTITY	MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation .
17363597	0	p53	78,81	MDM2	40,44	p53	MDM2	7157	4193	Gene	Gene	levels|compound|START_ENTITY oscillation|nmod|levels disrupts|dobj|oscillation disrupts|nsubj|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells .
17369817	0	p53	74,77	MDM2	34,38	p53	MDM2	7157	4193	Gene	Gene	dissociation|nmod|START_ENTITY dissociation|compound|END_ENTITY	C-terminal modifications regulate MDM2 dissociation and nuclear export of p53 .
17499002	0	p53	15,18	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	regulators|compound|START_ENTITY END_ENTITY|dep|regulators	MDM2 and MDM4 : p53 regulators as targets in anticancer therapy .
17848574	0	p53	20,23	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	suppressor|compound|START_ENTITY chaperones|dobj|suppressor chaperones|nsubj|END_ENTITY	MDM2 chaperones the p53 tumor suppressor .
17875722	0	p53	10,13	MDM2	80,84	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY Efficient|dobj|activation Efficient|nmod|disruption disruption|nmod|binding binding|nmod|END_ENTITY	Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX .
17971485	0	p53	56,59	MDM2	107,111	p53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY identifies|dobj|status identifies|nmod|inhibitors inhibitors|nummod|END_ENTITY	Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic_lymphocytic_leukemia .
18256546	0	p53	120,123	MDM2	29,33	p53	MDM2	7157	4193	Gene	Gene	peptides|compound|START_ENTITY modulates|nmod|peptides modulates|nsubj|surface surface|nmod|END_ENTITY	The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides .
18273046	0	p53	121,124	MDM2	0,4	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells inducer|nmod|apoptosis inducer|nsubj|END_ENTITY	MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute_lymphoblastic_leukemia cells with wild-type p53 and overexpression of MDM2 .
18273046	0	p53	121,124	MDM2	147,151	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells inducer|nmod|apoptosis inducer|nmod|END_ENTITY	MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute_lymphoblastic_leukemia cells with wild-type p53 and overexpression of MDM2 .
18316739	0	p53	23,26	MDM2	41,45	p53	MDM2	7157	4193	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition .
18414049	0	p53	108,111	MDM2	137,141	p53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY role|nmod|status uncovers|dobj|role uncovers|nmod|apoptosis apoptosis|nummod|END_ENTITY	The pre-clinical development of MDM2 inhibitors in chronic_lymphocytic_leukemia uncovers a central role for p53 status in sensitivity to MDM2 inhibitor-mediated apoptosis .
18414049	0	p53	108,111	MDM2	32,36	p53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY role|nmod|status uncovers|dobj|role uncovers|nsubj|development development|nmod|inhibitors inhibitors|nummod|END_ENTITY	The pre-clinical development of MDM2 inhibitors in chronic_lymphocytic_leukemia uncovers a central role for p53 status in sensitivity to MDM2 inhibitor-mediated apoptosis .
18566224	0	p53	16,19	MDM2	34,38	p53	MDM2	7157	4193	Gene	Gene	START_ENTITY|nmod|antagonist antagonist|compound|END_ENTITY	Reactivation of p53 by a specific MDM2 antagonist -LRB- MI-43 -RRB- leads to p21-mediated cell cycle arrest and selective cell death in colon_cancer .
18607552	0	p53	28,31	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY expression|nmod|pathway expression|compound|END_ENTITY	MDM2 mRNA expression in the p53 pathway may predict the potential of invasion and liver metastasis in colorectal_cancer .
18638452	0	p53	82,85	MDM2	35,39	p53	MDM2	7157	4193	Gene	Gene	acetylation|nmod|START_ENTITY regulate|dobj|acetylation indispensable|xcomp|regulate indispensable|nmod|END_ENTITY	Acidic domain is indispensable for MDM2 to negatively regulate the acetylation of p53 .
18826207	0	p53	109,112	MDM2	44,48	p53	MDM2	7157	4193	Gene	Gene	recognition|compound|START_ENTITY dissimilarities|nmod|recognition Targeting|nmod|dissimilarities Targeting|dobj|transitions transitions|nmod|END_ENTITY	Targeting the conformational transitions of MDM2 and MDMX : insights into dissimilarities and similarities of p53 recognition .
19098711	0	p53	16,19	MDM2	34,38	p53	MDM2	7157	4193	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|advcl|modulating modulating|dobj|END_ENTITY	RYBP stabilizes p53 by modulating MDM2 .
19166840	0	p53	33,36	MDM2	73,77	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulator|nmod|pathway FKBP25|appos|regulator induces|nsubj|FKBP25 induces|dobj|degradation degradation|nmod|END_ENTITY	FKBP25 , a novel regulator of the p53 pathway , induces the degradation of MDM2 and activation of p53 .
19166840	0	p53	96,99	MDM2	73,77	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	FKBP25 , a novel regulator of the p53 pathway , induces the degradation of MDM2 and activation of p53 .
19255450	0	p53	57,60	MDM2	79,83	p53	MDM2	7157	4193	Gene	Gene	interactions|compound|START_ENTITY inhibition|nmod|interactions basis|nmod|inhibition basis|nmod|END_ENTITY	Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX .
19286999	0	p53	21,24	MDM2	56,60	p53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	NPM-ALK inhibits the p53 tumor suppressor pathway in an MDM2 and JNK-dependent manner .
19321440	0	p53	24,27	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	acts|nmod|START_ENTITY acts|nummod|END_ENTITY	MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation .
19369353	0	p53	108,111	MDM2	85,89	p53	MDM2	7157	4193	Gene	Gene	suppressor|compound|START_ENTITY deregulate|dobj|suppressor sarcoma-associated_herpesvirus|xcomp|deregulate sarcoma-associated_herpesvirus|dobj|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway .
19375142	0	p53	71,74	MDM2	102,106	p53	MDM2	7157	4193	Gene	Gene	independent|compound|START_ENTITY independent|nmod|END_ENTITY	Expression of Epstein-Barr_virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2 , leading to repression of p53-mediated transcription .
19421231	0	p53	14,17	MDM2	21,25	p53	MDM2	7157	4193	Gene	Gene	START_ENTITY|nmod|antagonists antagonists|nummod|END_ENTITY	Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr_virus -LRB- EBV -RRB- - positive and EBV-negative Burkitt 's _ lymphoma cells .
19428175	0	p53	96,99	MDM2	29,33	p53	MDM2	7157	4193	Gene	Gene	independent|nmod|START_ENTITY expression|amod|independent oncogene|dobj|expression oncogene|nsubj|END_ENTITY	Gambogic_acid down-regulates MDM2 oncogene and induces p21 -LRB- Waf1/CIP1 -RRB- expression independent of p53 .
19507240	0	p53	96,99	MDM2	44,48	p53	MDM2	7157	4193	Gene	Gene	recognition|compound|START_ENTITY affecting|dobj|recognition residues|acl|affecting insights|nmod|residues insights|dep|Targeting Targeting|dobj|transitions transitions|nmod|END_ENTITY	Targeting the conformational transitions of MDM2 and MDMX : insights into key residues affecting p53 recognition .
19513075	0	p53	119,122	MDM2	54,58	p53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY dependent|nmod|status dependent|nsubj|association association|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	The association between the T309G polymorphism of the MDM2 gene and sensitivity to anticancer drug is dependent on the p53 mutational status in cellular models .
19565011	0	p53	99,102	MDM2	27,31	p53	MDM2	7157	4193	Gene	Gene	levels|compound|START_ENTITY dependent|nmod|levels dependent|nsubj|inhibition inhibition|nmod|protein protein|nummod|END_ENTITY	Progesterone inhibition of MDM2 p90 protein in MCF-7 human breast_cancer cell line is dependent on p53 levels .
19710698	0	p53	14,17	MDM2	49,53	p53	MDM2	7157	4193	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|antagonist antagonist|nmod|END_ENTITY	Activation of p53 by Nutlin-3a , an antagonist of MDM2 , induces apoptosis and cellular senescence in adult_T-cell_leukemia cells .
19713735	0	p53	52,55	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	family|compound|START_ENTITY based|nmod|family based|nsubj|Design Design|nmod|peptide peptide|compound|END_ENTITY	Design of a novel MDM2 binding peptide based on the p53 family .
19759023	0	p53	59,62	MDM2	43,47	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	stability|compound|START_ENTITY control|nmod|stability control|nummod|END_ENTITY	CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability .
19816404	0	p53	14,17	MDM2	32,36	p53	MDM2	7157	4193	Gene	Gene	activates|dobj|START_ENTITY activates|advcl|regulating regulating|dobj|oligomerization oligomerization|amod|END_ENTITY	ATM activates p53 by regulating MDM2 oligomerization and E3 processivity .
19842060	0	p53	0,3	MDM2	91,95	p53	MDM2	7157	4193	Gene	Gene	Promotes|nsubj|START_ENTITY Promotes|nmod|transcription transcription|nmod|END_ENTITY	p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2 .
19903807	0	p53	113,116	MDM2	36,40	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|activity activity|nmod|END_ENTITY	Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53 .
19910468	0	p53	79,82	MDM2	88,92	p53	MDM2	7157	4193	Gene	Gene	interaction|nmod|START_ENTITY inhibiting|dobj|interaction inhibiting|nmod|END_ENTITY	Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX .
19941079	0	p53	147,150	MDM2	16,20	p53	MDM2	7157	4193	Gene	Gene	tumors|compound|START_ENTITY patients|nmod|tumors stage|xcomp|patients stage|nsubj|Associations Associations|nmod|SNP309 SNP309|compound|END_ENTITY	Associations of MDM2 SNP309 , transcriptional activity , mRNA expression , and survival in stage I non-small-cell lung_cancer patients with wild-type p53 tumors .
19945467	0	p53	18,21	MDM2	76,80	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY mediated|nsubjpass|Downregulation mediated|nmod|END_ENTITY	Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2 .
19958516	0	p53	14,17	MDM2	29,33	p53	MDM2	7157	4193	Gene	Gene	Modulation|nmod|START_ENTITY binding|nsubj|Modulation binding|nmod|END_ENTITY	Modulation of p53 binding to MDM2 : computational studies reveal important roles of Tyr100 .
19958544	0	p53	37,40	MDM2	3,7	p53	MDM2	7157	4193	Gene	Gene	functions|compound|START_ENTITY restores|dobj|functions restores|nsubj|antagonist antagonist|compound|END_ENTITY	An MDM2 antagonist -LRB- MI-319 -RRB- restores p53 functions and increases the life span of orally treated follicular_lymphoma bearing animals .
20019189	0	p53	45,48	MDM2	29,33	p53	MDM2	7157	4193	Gene	Gene	activity|compound|START_ENTITY influences|dobj|activity influences|nsubj|regulation regulation|nmod|END_ENTITY	Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis .
20156675	0	p53	115,118	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	function|compound|START_ENTITY pancreatic_cancer|nmod|function treatment|nmod|pancreatic_cancer treatment|nsubj|MI-319 MI-319|compound|END_ENTITY	MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic_cancer independent of p53 function .
20157557	0	p53	40,43	MDM2	87,91	p53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY activity|nmod|pathway revealed|nsubj|activity revealed|nmod|nutlin-3 nutlin-3|compound|END_ENTITY	Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3 .
20190571	0	p53	24,27	MDM2	42,46	p53	MDM2	7157	4193	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Differential binding of p53 and nutlin to MDM2 and MDMX : computational studies .
20333547	0	p53	73,76	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	regulators|nmod|START_ENTITY Interplay|dep|regulators Interplay|nmod|END_ENTITY	Interplay between MDM2 , MDMX , Pirh2 and COP1 : the negative regulators of p53 .
20372076	0	p53	0,3	MDM2	20,24	p53	MDM2	7157	4193	Gene	Gene	inactivation|compound|START_ENTITY inactivation|nmod|loops loops|compound|END_ENTITY	p53 inactivation by MDM2 and MDMX negative feedback loops in testicular_germ_cell_tumors .
20406950	0	p53	139,142	MDM2	60,64	p53	MDM2	7157	4193	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing nutlin-3a|nmod|cells nutlin-3a|nsubj|activity activity|nmod|antagonist antagonist|compound|END_ENTITY	1,25-dihydroxyvitamin _ D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute_myeloid_leukemia cells expressing wild-type p53 .
20484049	0	p53	62,65	MDM2	107,111	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	degradation|compound|START_ENTITY promotes|dobj|degradation promotes|advcl|stabilizing stabilizing|dobj|END_ENTITY	Smad ubiquitylation regulatory factor 1/2 -LRB- Smurf1/2 -RRB- promotes p53 degradation by stabilizing the E3 ligase MDM2 .
20588255	0	p53	56,59	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	output|nummod|START_ENTITY regulates|dobj|output regulates|nsubj|recruitment recruitment|compound|END_ENTITY	MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output .
20588277	0	p53	135,138	MDM2	42,46	p53	MDM2	7157	4193	Gene	Gene	harbouring|dobj|START_ENTITY cells|acl|harbouring promotes|dobj|cells promotes|nsubj|Nutlin-3 Nutlin-3|appos|inhibitor inhibitor|nmod|END_ENTITY	Nutlin-3 , the small-molecule inhibitor of MDM2 , promotes senescence and radiosensitises laryngeal_carcinoma cells harbouring wild-type p53 .
20639885	0	p53	18,21	MDM2	53,57	p53	MDM2	7157	4193	Gene	Gene	terminus|nmod|START_ENTITY binds|nsubj|terminus binds|dobj|domain domain|nmod|END_ENTITY	The C terminus of p53 binds the N-terminal domain of MDM2 .
20680659	0	p53	86,89	MDM2	129,133	p53	MDM2	7157	4193	Gene	Gene	hyperacetylation|compound|START_ENTITY hyperacetylation|nmod|expression expression|compound|END_ENTITY	Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression .
20847049	0	p53	8,11	MDM2	44,48	p53	MDM2	7157	4193	Gene	Gene	site|compound|START_ENTITY site|nmod|signal signal|compound|END_ENTITY	A novel p53 phosphorylation site within the MDM2 ubiquitination signal : II .
20851891	0	p53	138,141	MDM2	44,48	p53	MDM2	7157	4193	Gene	Gene	function|compound|START_ENTITY inactivation|nmod|function linked|nmod|inactivation linked|nsubjpass|site site|nmod|signal signal|compound|END_ENTITY	A novel p53 phosphorylation site within the MDM2 ubiquitination signal : I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function .
20851891	0	p53	8,11	MDM2	44,48	p53	MDM2	7157	4193	Gene	Gene	site|compound|START_ENTITY site|nmod|signal signal|compound|END_ENTITY	A novel p53 phosphorylation site within the MDM2 ubiquitination signal : I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function .
21060154	0	p53	28,31	MDM2	40,44	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nmod|END_ENTITY	Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice .
21191186	0	p53	57,60	MDM2	43,47	p53	MDM2	7157	4193	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|states states|nmod|lid lid|nmod|END_ENTITY	Chemical states of the N-terminal `` lid '' of MDM2 regulate p53 binding : simulations reveal complexities of modulation .
21261729	0	p53	93,96	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	types|nmod|START_ENTITY inhibit|nmod|types inhibit|nsubj|antagonist antagonist|compound|END_ENTITY	MDM2 antagonist can inhibit tumor growth in hepatocellular_carcinoma with different types of p53 in vitro .
21295542	0	p53	88,91	MDM2	48,52	p53	MDM2	7157	4193	Gene	Gene	formation|nmod|START_ENTITY represses|nmod|formation represses|dobj|transactivation transactivation|nmod|END_ENTITY	CREB represses p53-dependent transactivation of MDM2 through the complex formation with p53 and contributes to p53-mediated apoptosis in response to glucose_deprivation .
21314128	0	p53	62,65	MDM2	56,60	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY inhibitors|dep|interaction inhibitors|nmod|murine_double_minute_2 murine_double_minute_2|appos|END_ENTITY	Isoindolinone inhibitors of the murine_double_minute_2 -LRB- MDM2 -RRB- - p53 protein-protein interaction : structure-activity studies leading to improved potency .
21391906	0	p53	28,31	MDM2	50,54	p53	MDM2	7157	4193	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|antagonists antagonists|compound|END_ENTITY	Pharmacologic activation of p53 by small-molecule MDM2 antagonists .
21454483	0	p53	14,17	MDM2	46,50	p53	MDM2	7157	4193	Gene	Gene	binding|compound|START_ENTITY Inhibition|nmod|binding function|nsubj|Inhibition function|nmod|domain domain|compound|END_ENTITY	Inhibition of p53 DNA binding function by the MDM2 protein acidic domain .
21460101	0	p53	27,30	MDM2	87,91	p53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|cells cells|acl|using using|dobj|END_ENTITY	Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist nutlin-3 .
21478269	0	p53	101,104	MDM2	38,42	p53	MDM2	7157	4193	Gene	Gene	stabilization|nmod|START_ENTITY causes|dobj|stabilization causes|nsubj|inactivation inactivation|nmod|END_ENTITY	Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells .
21685937	0	p53	57,60	MDM2	82,86	p53	MDM2	7157	4193	Gene	Gene	inactivating|dobj|START_ENTITY inactivating|nmod|phosphorylation phosphorylation|compound|END_ENTITY	SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival .
21785463	0	p53	33,36	MDM2	64,68	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	stabilization|compound|START_ENTITY regulates|dobj|stabilization regulates|advcl|enhancing enhancing|dobj|END_ENTITY	JAK2 -LRB- V617F -RRB- negatively regulates p53 stabilization by enhancing MDM2 via La expression in myeloproliferative_neoplasms .
21900752	0	p53	39,42	MDM2	0,4	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	modification|nmod|START_ENTITY SUMO-2|dep|modification promotes|xcomp|SUMO-2 promotes|nsubj|END_ENTITY	MDM2 promotes SUMO-2 / 3 modification of p53 to modulate transcriptional activity .
22134502	0	p53	56,59	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY significance|nmod|status modifies|dobj|significance modifies|nsubj|SNP309 SNP309|compound|END_ENTITY	MDM2 SNP309 modifies the prognostic significance of the p53 mutational status in patients with ovarian_cancer .
22208493	0	p53	79,82	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nsubj|amplification amplification|nummod|END_ENTITY	MDM2 amplification in malignant_peripheral_nerve_sheath_tumors correlates with p53 protein expression .
22348305	0	p53	30,33	MDM2	76,80	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	suppression|nmod|START_ENTITY inhibited|nsubjpass|suppression inhibited|nmod|p19 p19|nmod|END_ENTITY	Bach1-mediated suppression of p53 is inhibited by p19 -LRB- ARF -RRB- independently of MDM2 .
22377766	0	p53	96,99	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	role|nmod|START_ENTITY induces|parataxis|role induces|nsubj|nutlin-3a nutlin-3a|compound|END_ENTITY	MDM2 inhibitor nutlin-3a induces apoptosis and senescence in cutaneous_T-cell_lymphoma : role of p53 .
22411991	0	p53	43,46	MDM2	81,85	p53	MDM2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY leads|nmod|degradation leads|nmod|regulation regulation|nmod|sumoylation sumoylation|compound|END_ENTITY	Overexpression of SKI_oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation .
22444248	0	p53	41,44	MDM2	136,140	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY phosphorylation|nmod|activation Interrogation|nmod|phosphorylation using|nsubj|Interrogation using|parataxis|reexamined reexamined|nsubj|role role|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation : the functional role of Ser17 phosphorylation in MDM2 reexamined .
22444248	0	p53	41,44	MDM2	17,21	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY phosphorylation|nmod|activation phosphorylation|nummod|END_ENTITY	Interrogation of MDM2 phosphorylation in p53 activation using native chemical ligation : the functional role of Ser17 phosphorylation in MDM2 reexamined .
22525275	0	p53	22,25	MDM2	52,56	p53	MDM2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY promotes|dobj|degradation promotes|advcl|inhibiting inhibiting|dobj|auto-ubiquitination auto-ubiquitination|nummod|END_ENTITY	Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic_syndrome with chromosome 5q deletion .
22578852	0	p53	114,117	MDM2	42,46	p53	MDM2	7157	4193	Gene	Gene	mutation|compound|START_ENTITY lines|nmod|mutation Comparison|nmod|lines Comparison|nmod|effects effects|nmod|END_ENTITY	Comparison of the antitumor effects of an MDM2 inhibitor , nutlin-3 , in feline lymphoma cell lines with or without p53 mutation .
22703554	0	p53	131,134	MDM2	177,181	p53	MDM2	7157	4193	Gene	Gene	concomitant|compound|START_ENTITY pattern|nmod|concomitant displaying|dobj|pattern displaying|nmod|expression expression|compound|END_ENTITY	Hypermethylation of the 5 ' CpG island of the p14ARF flanking exon 1b in human colorectal_cancer displaying a restricted pattern of p53 overexpression concomitant with increased MDM2 expression .
22745160	0	p53	18,21	MDM2	56,60	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY pathway|nsubj|Activation pathway|nmod|END_ENTITY	Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization .
22807444	0	p53	122,125	MDM2	76,80	p53	MDM2	7157	4193	Gene	Gene	interaction|compound|START_ENTITY regulating|dobj|interaction implications|acl|regulating binding|dep|implications binding|nmod|subdomains subdomains|nmod|protein protein|compound|END_ENTITY	Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein : implications for regulating the p53 MDM2/MDMX interaction .
22807444	0	p53	36,39	MDM2	76,80	p53	MDM2	7157	4193	Gene	Gene	subdomains|compound|START_ENTITY subdomains|nmod|protein protein|compound|END_ENTITY	Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein : implications for regulating the p53 MDM2/MDMX interaction .
23032264	0	p53	62,65	MDM2	46,50	p53	MDM2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY prevent|dobj|degradation represses|xcomp|prevent represses|dobj|activation activation|nmod|END_ENTITY	cIAP2 represses IKKa/b-mediated activation of MDM2 to prevent p53 degradation .
23150753	0	p53	27,30	MDM2	68,72	p53	MDM2	7157	4193	Gene	Gene	Responses|compound|START_ENTITY Regulation|nmod|Responses Mediated|nsubjpass|Regulation Mediated|nmod|END_ENTITY	The Regulation of Multiple p53 Stress Responses is Mediated through MDM2 .
23150757	0	p53	134,137	MDM2	115,119	p53	MDM2	7157	4193	Gene	Gene	Activity|compound|START_ENTITY Repression|nmod|Activity Repression|compound|END_ENTITY	Dual Roles of MDM2 in the Regulation of p53 : Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity .
23150757	0	p53	40,43	MDM2	14,18	p53	MDM2	7157	4193	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nmod|Regulation	Dual Roles of MDM2 in the Regulation of p53 : Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity .
23150760	0	p53	66,69	MDM2	13,17	p53	MDM2	7157	4193	Gene	Gene	Signaling|nmod|START_ENTITY Roles|nmod|Signaling Roles|nmod|Phosphorylation Phosphorylation|compound|END_ENTITY	The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53 .
23201157	0	p53	45,48	MDM2	79,83	p53	MDM2	7157	4193	Gene	Gene	phosphorylation|nmod|START_ENTITY inhibits|nsubj|phosphorylation inhibits|nmod|END_ENTITY	A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2 .
23324352	0	p53	35,38	MDM2	67,71	p53	MDM2	7157	4193	Gene	Gene	mechanisms|nmod|START_ENTITY peptide|nsubj|mechanisms peptide|nmod|proteins proteins|compound|END_ENTITY	On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins : a Brownian dynamics study .
23398638	0	p53	21,24	MDM2	81,85	p53	MDM2	7157	4193	Gene	Gene	access|nmod|START_ENTITY regulates|nsubj|access regulates|nmod|END_ENTITY	Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2 .
23400593	0	p53	48,51	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|RG7112 RG7112|nummod|END_ENTITY	MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models .
23623661	0	p53	10,13	MDM2	61,65	p53	MDM2	7157	4193	Gene	Gene	function|nsubj|START_ENTITY function|nmod|END_ENTITY	Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin_B1 / CDK1-phosphorylated nuclear iASPP .
23652204	0	p53	102,105	MDM2	52,56	p53	MDM2	7157	4193	Gene	Gene	ligases|nmod|START_ENTITY ligases|dobj|apoptosis apoptosis|compound|END_ENTITY	A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53 .
23826318	0	p53	27,30	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	Independently|compound|START_ENTITY Inhibits|dobj|Independently Inhibits|nsubj|END_ENTITY	MDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity .
23839035	0	p53	43,46	MDM2	66,70	p53	MDM2	7157	4193	Gene	Gene	pathways|compound|START_ENTITY crosstalk|nmod|pathways mechanism|nmod|crosstalk mechanism|dep|binds binds|nummod|END_ENTITY	A novel mechanism of crosstalk between the p53 and NFkB pathways : MDM2 binds and inhibits p65RelA .
23977270	0	p53	31,34	MDM2	59,63	p53	MDM2	7157	4193	Gene	Gene	reactivation|compound|START_ENTITY reactivation|nmod|inhibitor inhibitor|compound|END_ENTITY	Human glioblastoma_multiforme : p53 reactivation by a novel MDM2 inhibitor .
24240203	0	p53	72,75	MDM2	28,32	p53	MDM2	7157	4193	Gene	Gene	reactivates|dobj|START_ENTITY reactivates|nsubj|overexpression overexpression|compound|END_ENTITY	Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood_leukemia .
24264557	0	p53	86,89	MDM2	70,74	p53	MDM2	7157	4193	Gene	Gene	bindings|compound|START_ENTITY induced|nmod|bindings induced|nsubj|analysis analysis|nmod|modes modes|nmod|END_ENTITY	A computational analysis of binding modes and conformation changes of MDM2 induced by p53 and inhibitor bindings .
24309210	0	p53	14,17	MDM2	25,29	p53	MDM2	7157	4193	Gene	Gene	START_ENTITY|nmod|RG7112 RG7112|compound|END_ENTITY	Activation of p53 by the MDM2 inhibitor RG7112 impairs thrombopoiesis .
24356649	0	p53	37,40	MDM2	8,12	p53	MDM2	7157	4193	Gene	Gene	accumulation|compound|START_ENTITY promote|dobj|accumulation isoforms|xcomp|promote isoforms|nsubj|END_ENTITY	Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis .
24418072	0	p53	72,75	MDM2	101,105	p53	MDM2	7157	4193	Gene	Gene	analogs|compound|START_ENTITY stability|nmod|analogs origin|nmod|stability Probing|dobj|origin bound|csubj|Probing bound|nmod|END_ENTITY	Probing the origin of structural stability of single and double stapled p53 peptide analogs bound to MDM2 .
24584189	0	p53	0,3	MDM2	61,65	p53	MDM2	7157	4193	Gene	Gene	START_ENTITY|nmod|terminal terminal|dep|END_ENTITY	p53 N - terminal binding and stabilisation by PIAS3 inhibits MDM2 - induced p53 ubiquitination and regulates cell growth .
24584189	0	p53	76,79	MDM2	61,65	p53	MDM2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY induced|dobj|ubiquitination induced|dep|p53 p53|nmod|terminal terminal|dep|END_ENTITY	p53 N - terminal binding and stabilisation by PIAS3 inhibits MDM2 - induced p53 ubiquitination and regulates cell growth .
24882579	0	p53	25,28	MDM2	67,71	p53	MDM2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY regulates|dobj|pathway regulates|advcl|targeting targeting|dobj|END_ENTITY	miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2 .
25172547	0	p53	51,54	MDM2	77,81	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY downregulates|dobj|expression downregulates|nmod|activation activation|nmod|END_ENTITY	Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B .
25181509	0	p53	89,92	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	models|compound|START_ENTITY induces|nmod|models induces|nsubj|Inhibition Inhibition|nmod|Ligase Ligase|compound|END_ENTITY	Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple_myeloma , and acts synergistically with ABT-737 .
25263199	0	p53	23,26	MDM2	42,46	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	START_ENTITY|amod|due due|nmod|loss loss|nmod|END_ENTITY	Aberrant activation of p53 due to loss of MDM2 or MDMX causes early lens_dysmorphogenesis .
25275651	0	p53	44,47	MDM2	39,43	p53	MDM2	7157	4193	Gene	Gene	Interaction|compound|START_ENTITY Basis|dep|Interaction Basis|nmod|Inhibition Inhibition|nmod|END_ENTITY	Structural Basis for Inhibition of the MDM2 : p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display .
25543083	0	p53	89,92	MDM2	49,53	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	Polyubiquitination|nmod|START_ENTITY Enhances|dobj|Polyubiquitination Enhances|nsubj|Mutation Mutation|nmod|Lid Lid|nmod|END_ENTITY	Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis .
25584963	0	p53	51,54	MDM2	95,99	p53	MDM2	7157	4193	Gene	Gene	effect|nmod|START_ENTITY characterization|nmod|effect phosphorylation|nsubj|characterization phosphorylation|nmod|END_ENTITY	A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2 .
25591003	0	p53	39,42	MDM2	77,81	p53	MDM2	7157	4193	Gene	Gene	transactivation|compound|START_ENTITY convergence|nmod|transactivation domains|nsubj|convergence domains|nmod|recognition recognition|compound|END_ENTITY	Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition .
25840370	0	p53	61,64	MDM2	76,80	p53	MDM2	7157	4193	Gene	Gene	peptide|compound|START_ENTITY peptide|nmod|END_ENTITY	The cis conformation of proline leads to weaker binding of a p53 peptide to MDM2 compared to trans .
25902914	0	p53	122,125	MDM2	57,61	p53	MDM2	7157	4193	Gene	Gene	stabilize|dobj|START_ENTITY promotes|xcomp|stabilize promotes|dobj|regulation regulation|nmod|transcription transcription|nummod|END_ENTITY	Oroxylin_A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells .
26220995	0	p53	76,79	MDM2	19,23	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY basis|nmod|activation reveals|dobj|basis reveals|nsubj|Structure Structure|nmod|END_ENTITY	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
26220995	0	p53	76,79	MDM2	19,23	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY basis|nmod|activation reveals|dobj|basis reveals|nsubj|Structure Structure|nmod|END_ENTITY	Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation .
26350565	0	p53	59,62	MDM2	109,113	p53	MDM2	7157	4193	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast_cancer cells .
26428461	0	p53	125,128	MDM2	32,36	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY temozolomide|nmod|activation glioblastoma|xcomp|temozolomide sensitizes|xcomp|glioblastoma sensitizes|nsubj|antagonist antagonist|nmod|END_ENTITY	A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation .
26431162	0	p53	23,26	MDM2	42,46	p53	MDM2	7157	4193	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34 + proliferating and quiescent chronic_myeloid_leukemia blast_crisis cells .
26440941	0	p53	35,38	MDM2	0,4	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	Autophagy|compound|START_ENTITY Inhibitor|appos|Autophagy Inhibitor|compound|END_ENTITY	MDM2 Inhibitor , Nutlin 3a , Induces p53 Dependent Autophagy in Acute Leukemia by AMP Kinase Activation .
26475335	0	p53	52,55	MDM2	47,51	p53	MDM2	7157	4193	Gene	Gene	Axis|compound|START_ENTITY SAR405838|dep|Axis SAR405838|dep|Inhibitor Inhibitor|nmod|END_ENTITY	SAR405838 : A Novel and Potent Inhibitor of the MDM2 : p53 Axis for the Treatment of Dedifferentiated_Liposarcoma .
26492369	0	p53	16,19	MDM2	24,28	p53	MDM2	7157	4193	Gene	Gene	Reactivation|nmod|START_ENTITY Reactivation|nmod|inhibition inhibition|compound|END_ENTITY	Reactivation of p53 via MDM2 inhibition .
26823446	0	p53	0,3	MDM2	80,84	p53	MDM2	7157	4193	Gene	Gene	mRNA|compound|START_ENTITY Have|nsubj|mRNA Have|ccomp|Interact Interact|nmod|END_ENTITY	p53 mRNA and p53 Protein Structures Have Evolved Independently to Interact with MDM2 .
26832796	0	p53	33,36	MDM2	117,121	p53	MDM2	7157	4193	Gene	Gene	inhibition|nmod|START_ENTITY potentiates|nsubj|inhibition potentiates|nmod|inhibitors inhibitors|nummod|END_ENTITY	Chemical inhibition of wild-type p53 induced phosphatase 1 -LRB- WIP1/PPM1D -RRB- by GSK2830371 potentiates the sensitivity to MDM2 inhibitors in a p53-dependent manner .
26840028	0	p53	69,72	MDM2	24,28	p53	MDM2	7157	4193	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|xcomp|regulate	microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis .
26998348	0	p53	77,80	MDM2	4,8	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	neuroblastoma|compound|START_ENTITY inhibition|nmod|neuroblastoma leads|nmod|inhibition leads|nsubj|RG7388 RG7388|nummod|END_ENTITY	The MDM2 small-molecule inhibitor RG7388 leads to potent tumor inhibition in p53 wild-type neuroblastoma .
27040927	0	p53	0,3	MDM2	37,41	p53	MDM2	7157	4193	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	p53 expression and relationship with MDM2 amplification in breast_carcinomas .
7618270	0	p53	19,22	MDM2	114,118	p53	MDM2	7157	4193	Gene	Gene	cells|nummod|START_ENTITY levels|nmod|cells cause|nsubj|levels cause|dobj|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression .
7624121	0	p53	161,164	MDM2	129,133	p53	MDM2	7157	4193	Gene	Gene	arrest|compound|START_ENTITY protein|nmod|arrest protein|compound|END_ENTITY	Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal_adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation .
7624121	0	p53	59,62	MDM2	129,133	p53	MDM2	7157	4193	Gene	Gene	dominant|nmod|START_ENTITY dominant|advcl|demonstrated demonstrated|nmod|induction induction|nmod|protein protein|compound|END_ENTITY	Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal_adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation .
7624121	0	p53	7,10	MDM2	129,133	p53	MDM2	7157	4193	Gene	Gene	dominant|nsubj|START_ENTITY dominant|advcl|demonstrated demonstrated|nmod|induction induction|nmod|protein protein|compound|END_ENTITY	Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal_adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation .
7698255	0	p53	13,16	MDM2	19,23	p53	MDM2	7157	4193	Gene	Gene	Induction|nmod|START_ENTITY Induction|dep|END_ENTITY	Induction of p53 - , MDM2 - , and WAF1/CIP1-like molecules in insect cells by DNA-damaging agents .
7756655	0	p53	68,71	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	protein|compound|START_ENTITY stabilization|nmod|protein account|nmod|stabilization account|nsubj|overexpression overexpression|compound|END_ENTITY	MDM2 overexpression does not account for stabilization of wild-type p53 protein in non-Hodgkin 's _ lymphomas .
7888679	0	p53	105,108	MDM2	22,26	p53	MDM2	7157	4193	Gene	Gene	gene|compound|START_ENTITY expressing|dobj|gene Overexpression|acl|expressing Overexpression|nmod|gene gene|compound|END_ENTITY	Overexpression of the MDM2 gene by childhood acute_lymphoblastic_leukemia cells expressing the wild-type p53 gene .
8058315	0	p53	103,106	MDM2	55,59	p53	MDM2	7157	4193	Gene	Gene	site|nmod|START_ENTITY mapping|nmod|site analysis|dep|mapping analysis|nmod|interaction interaction|nmod|p53 p53|nmod|END_ENTITY	Immunochemical analysis of the interaction of p53 with MDM2 ; -- fine mapping of the MDM2 binding site on p53 using synthetic peptides .
8058315	0	p53	103,106	MDM2	82,86	p53	MDM2	7157	4193	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Immunochemical analysis of the interaction of p53 with MDM2 ; -- fine mapping of the MDM2 binding site on p53 using synthetic peptides .
8058315	0	p53	46,49	MDM2	82,86	p53	MDM2	7157	4193	Gene	Gene	interaction|nmod|START_ENTITY analysis|nmod|interaction analysis|dep|mapping mapping|nmod|site site|compound|END_ENTITY	Immunochemical analysis of the interaction of p53 with MDM2 ; -- fine mapping of the MDM2 binding site on p53 using synthetic peptides .
8334996	0	p53	33,36	MDM2	98,102	p53	MDM2	7157	4193	Gene	Gene	binding|nmod|START_ENTITY DNA|amod|binding DNA|dep|identification identification|nmod|sites sites|nmod|complexes complexes|amod|binding binding|nmod|p53 p53|dep|END_ENTITY	Sequence-specific DNA binding by p53 : identification of target sites and lack of binding to p53 - MDM2 complexes .
8350630	0	p53	54,57	MDM2	28,32	p53	MDM2	7157	4193	Gene	Gene	function|compound|START_ENTITY regulator|nmod|function Absence|appos|regulator Absence|nmod|amplification amplification|nmod|gene gene|compound|END_ENTITY	Absence of amplification of MDM2 gene , a regulator of p53 function , in myelodysplastic_syndromes .
8378080	0	p53	30,33	MDM2	59,63	p53	MDM2	7157	4193	Gene	Gene	infrequent|dep|START_ENTITY mutations|amod|infrequent spectrum|nmod|mutations spectrum|nmod|amplification amplification|compound|END_ENTITY	Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing_tumours .
8413278	0	p53	21,24	MDM2	106,110	p53	MDM2	7157	4193	Gene	Gene	bind|nsubj|START_ENTITY bind|nmod|domains domains|nmod|protein protein|compound|END_ENTITY	The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein .
8504413	0	p53	97,100	MDM2	40,44	p53	MDM2	7157	4193	Gene	Gene	mutations|compound|START_ENTITY Amplification|nmod|mutations Amplification|nmod|gene gene|compound|END_ENTITY	Amplification and overexpression of the MDM2 gene in a subset of human malignant_gliomas without p53 mutations .
8570197	0	p53	38,41	MDM2	0,4	p53	MDM2	7157	4193	Gene	Gene	absence|nmod|START_ENTITY transformation|nmod|absence transformation|nummod|END_ENTITY	MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest .
8625108	0	p53	35,38	MDM2	22,26	p53	MDM2	7157	4193	Gene	Gene	protein|compound|START_ENTITY gene|appos|protein gene|compound|END_ENTITY	The expression of the MDM2 gene , a p53 binding protein , in thyroid_carcinogenesis .
8875929	0	p53	47,50	MDM2	17,21	p53	MDM2	7157	4193	Gene	Gene	domain|compound|START_ENTITY bound|nmod|domain bound|nsubj|Structure Structure|nmod|oncoprotein oncoprotein|compound|END_ENTITY	Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain .
8932331	0	p53	70,73	MDM2	15,19	p53	MDM2	7157	4193	Gene	Gene	presence|nmod|START_ENTITY correlated|nmod|presence correlated|nsubjpass|levels levels|nmod|END_ENTITY	High levels of MDM2 are not correlated with the presence of wild-type p53 in human malignant_mesothelioma cell lines .
9072003	0	p53	85,88	MDM2	105,109	p53	MDM2	7157	4193	Gene	Gene	status|compound|START_ENTITY status|dep|+ +|appos|END_ENTITY	p21WAF1/CIP1 and MDM2 expression in non-Hodgkin 's _ lymphoma and their relationship to p53 status : a p53 + , MDM2 - , _ p21-immunophenotype associated with missense p53 mutations .
9072003	0	p53	99,102	MDM2	105,109	p53	MDM2	7157	4193	Gene	Gene	+|compound|START_ENTITY +|appos|END_ENTITY	p21WAF1/CIP1 and MDM2 expression in non-Hodgkin 's _ lymphoma and their relationship to p53 status : a p53 + , MDM2 - , _ p21-immunophenotype associated with missense p53 mutations .
9178766	0	p53	24,27	MDM2	89,93	p53	MDM2	7157	4193	Gene	Gene	terminus|nmod|START_ENTITY mimics|nsubj|terminus mimics|dobj|effect effect|nmod|phosphorylation phosphorylation|compound|END_ENTITY	The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation .
9363941	0	p53	38,41	MDM2	67,71	p53	MDM2	7157	4193	Gene	Gene	phosphorylation|nmod|START_ENTITY alleviates|nsubj|phosphorylation alleviates|nmod|END_ENTITY	DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 .
9388063	0	p53	14,17	MDM2	19,23	p53	MDM2	7157	4193	Gene	Gene	bcl-2|compound|START_ENTITY bcl-2|dep|END_ENTITY	Expression of p53 , MDM2 , p21waf1 , bcl-2 , and retinoblastoma gene proteins in myelodysplastic_syndrome after autologous bone marrow_transplantation_for_lymphoma .
9419352	0	p53	26,29	MDM2	47,51	p53	MDM2	7157	4193	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|amod|END_ENTITY	Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage .
9450543	0	p53	63,66	MDM2	12,16	p53	MDM2	7157	4193	Gene	Gene	E3|nmod|START_ENTITY E3|nsubj|END_ENTITY	Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 .
9472631	0	p53	11,14	MDM2	97,101	p53	MDM2	7157	4193	Gene	Gene	mutants|compound|START_ENTITY Effects|nmod|mutants derived|nsubj|Effects derived|nmod|element element|nmod|gene gene|compound|END_ENTITY	Effects of p53 mutants derived from lung_carcinomas on the p53-responsive element -LRB- p53RE -RRB- of the MDM2 gene .
9529248	0	p53	106,109	MDM2	85,89	p53	MDM2	7157	4193	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod:poss|END_ENTITY	The Ink4a tumor suppressor gene product , p19Arf , interacts with MDM2 and neutralizes MDM2 's inhibition of p53 .
9569028	0	p53	90,93	MDM2	18,22	p53	MDM2	7157	4193	Gene	Gene	inactivation|nmod|START_ENTITY results|nmod|inactivation results|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of MDM2 , due to enhanced translation , results in inactivation of wild-type p53 in Burkitt 's _ lymphoma cells .
9651526	0	p53	66,69	MDM2	0,4	p53	MDM2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	MDM2 expression during mouse embryogenesis and the requirement of p53 .
9819415	0	p53	57,60	MDM2	64,68	p53	MDM2	7157	4193	Gene	Gene	degradation|nmod|START_ENTITY required|nmod|degradation required|nmod|E6 E6|compound|END_ENTITY	Nuclear export is required for degradation of endogenous p53 by MDM2 and human_papillomavirus E6 .
9875138	0	p53	53,56	MDM2	68,72	p53	MDM2	7157	4193	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	No evidence for functional inactivation of wild-type p53 protein by MDM2 overexpression in gastric_carcinogenesis .
10075736	0	p53	113,116	MDMX	8,12	p53	MDMX	7157	4194	Gene	Gene	activity|compound|START_ENTITY encodes|nmod|activity encodes|nsubj|transcript transcript|compound|END_ENTITY	A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity .
12162806	0	p53	51,54	MDMX	0,4	p53	MDMX	7157	4194	Gene	Gene	acetylation|nmod|START_ENTITY inhibits|dobj|acetylation inhibits|nsubj|END_ENTITY	MDMX inhibits the p300/CBP-mediated acetylation of p53 .
14660608	0	p53	68,71	MDMX	6,10	p53	MDMX	22060(Tax:10090)	17248(Tax:10090)	Gene	Gene	stabilization|nmod|START_ENTITY enhances|dobj|stabilization enhances|nsubj|overexpression overexpression|appos|END_ENTITY	MDM4 -LRB- MDMX -RRB- overexpression enhances stabilization of stress-induced p53 and promotes apoptosis .
16163388	0	p53	61,64	MDMX	42,46	p53	MDMX	7157	4194	Gene	Gene	activation|compound|START_ENTITY contribute|nmod|activation contribute|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage .
16511572	0	p53	84,87	MDMX	21,25	p53	MDMX	7157	4194	Gene	Gene	activation|compound|START_ENTITY resulting|nmod|activation phosphorylated|xcomp|resulting END_ENTITY|acl:relcl|phosphorylated	14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1 , resulting in p53 activation .
16905541	0	p53	29,32	MDMX	0,4	p53	MDMX	7157	4194	Gene	Gene	activation|compound|START_ENTITY prevents|dobj|activation prevents|nsubj|overexpression overexpression|compound|END_ENTITY	MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin .
17110929	0	p53	19,22	MDMX	0,4	p53	MDMX	22060(Tax:10090)	17248(Tax:10090)	Gene	Gene	response|compound|START_ENTITY regulation|nmod|response regulation|compound|END_ENTITY	MDMX regulation of p53 response to ribosomal stress .
17327702	0	p53	44,47	MDMX	18,22	p53	MDMX	7157	4194	Gene	Gene	response|compound|START_ENTITY regulation|nmod|response roles|nmod|regulation roles|nmod|END_ENTITY	Distinct roles of MDMX in the regulation of p53 response to ribosomal stress .
20697359	0	p53	79,82	MDMX	20,24	p53	MDMX	7157	4194	Gene	Gene	activity|compound|START_ENTITY control|nmod|activity facet|nmod|control p76|dep|facet function|nmod|p76 function|nsubj|Regulation Regulation|appos|END_ENTITY	Regulation of MDM4 -LRB- MDMX -RRB- function by p76 -LRB- MDM2 -RRB- : a new facet in the control of p53 activity .
21075910	0	p53	45,48	MDMX	30,34	p53	MDMX	7157	4194	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|inhibitor inhibitor|nmod|END_ENTITY	A small-molecule inhibitor of MDMX activates p53 and induces apoptosis .
21750655	0	p53	17,20	MDMX	68,72	p53	MDMX	7157	4194	Gene	Gene	activator|compound|START_ENTITY induces|nsubj|activator induces|advcl|inhibiting inhibiting|dobj|expression expression|compound|END_ENTITY	A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast_cancer cells .
23028042	0	p53	75,78	MDMX	30,34	p53	MDMX	7157	4194	Gene	Gene	stimulate|dobj|START_ENTITY regulates|xcomp|stimulate regulates|dobj|interaction interaction|compound|END_ENTITY	Casein kinase 1a regulates an MDMX intramolecular interaction to stimulate p53 binding .
24190973	0	p53	37,40	MDMX	60,64	p53	MDMX	7157	4194	Gene	Gene	induces|dobj|START_ENTITY induces|advcl|phosphorylating phosphorylating|dobj|END_ENTITY	AMP-activated_protein_kinase induces p53 by phosphorylating MDMX and inhibiting its activity .
25825738	0	p53	41,44	MDMX	18,22	p53	MDMX	7157	4194	Gene	Gene	mimicry|compound|START_ENTITY Autoinhibition|nmod|mimicry Autoinhibition|nmod|END_ENTITY	Autoinhibition of MDMX by intramolecular p53 mimicry .
26148237	0	p53	70,73	MDMX	39,43	p53	MDMX	7157	4194	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|phosphorylation phosphorylation|compound|END_ENTITY	Structural basis of how stress-induced MDMX phosphorylation activates p53 .
15201979	0	p53	43,46	MIB-1	65,70	p53	MIB-1	7157	57534	Gene	Gene	expression|nmod|START_ENTITY expression|amod|HER-2 HER-2|amod|END_ENTITY	Relation between HPV-DNA and expression of p53 , bcl-2 , p21WAF-1 , MIB-1 , HER-2 / neu and DNA ploidy in early cervical carcinoma : correlation with clinical outcome .
16328355	0	p53	58,61	MIB-1	46,51	p53	MIB-1	7157	57534	Gene	Gene	p16|nummod|START_ENTITY p16|compound|END_ENTITY	Expression of cell cycle-regulatory proteins , MIB-1 , p16 , p53 , and p63 , in squamous_cell_carcinoma of conjunctiva : not associated with human_papillomavirus_infection .
20414055	0	p53	42,45	MIB-1	65,70	p53	MIB-1	7157	57534	Gene	Gene	protein|compound|START_ENTITY overexpression|nmod|protein overexpression|appos|END_ENTITY	Immunohistochemical overexpression of the p53 protein and Ki-67 -LRB- MIB-1 -RRB- antigen in patients with GERD and chronic_esophagitis .
20598040	0	p53	15,18	MIB-1	30,35	p53	MIB-1	7157	57534	Gene	Gene	expressions|amod|START_ENTITY expressions|appos|END_ENTITY	Correlation of p53 and Ki-67 -LRB- MIB-1 -RRB- expressions with clinicopathological features and prognosis of early stage cervical squamous_cell_carcinomas .
8735719	0	p53	130,133	MIB-1	0,5	p53	MIB-1	7157	57534	Gene	Gene	characteristics|amod|START_ENTITY correlations|nmod|characteristics study|nmod|correlations expression|dep|study expression|compound|END_ENTITY	MIB-1 expression and iododeoxyuridine labelling in soft tissue sarcomas : an immunohistochemical study including correlations with p53 , bcl-2 and histological characteristics .
9477105	0	p53	107,110	MIB-1	112,117	p53	MIB-1	7157	57534	Gene	Gene	grade|nmod|START_ENTITY grade|amod|END_ENTITY	Invasion of the bladder_by_transitional_cell_carcinoma : its relation to histologic grade and expression of p53 , MIB-1 , c-erb_B-2 , epidermal_growth_factor_receptor , and bcl-2 .
9493195	0	p53	17,20	MIB-1	73,78	p53	MIB-1	7157	57534	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- Significance of p53 protein expression and proliferative potential with MIB-1 on tumor recurrence of pituitary_adenomas -RSB- .
16006797	0	p53	129,132	MIB1	134,138	p53	MIB1	7157	57534	Gene	Gene	neu|compound|START_ENTITY neu|dep|END_ENTITY	An immunohistochemical comparison between low-grade and high-grade ovarian_serous_carcinomas : significantly higher expression of p53 , MIB1 , BCL2 , HER-2 / neu , and C-KIT in high-grade neoplasms .
12082608	0	p53	95,98	MIC-1	49,54	p53	MIC-1	7157	9518	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Anoxia induces macrophage_inhibitory_cytokine-1 -LRB- MIC-1 -RRB- in glioblastoma cells independently of p53 and HIF-1 .
24942805	0	p53	35,38	MIR-23a	96,103	p53	MIR-23a	7157	407010	Gene	Gene	up-regulation|compound|START_ENTITY suppressor|dep|up-regulation gets|nsubj|suppressor gets|xcomp|involved involved|nmod|network network|nmod|END_ENTITY	Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular_carcinoma .
12890671	0	p53	52,55	MKP1	16,20	p53	MKP1	7157	1843	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation .
15611668	0	p53	0,3	MKP1	35,39	p53	MKP1	7157	1843	Gene	Gene	Transactivates|nsubj|START_ENTITY Transactivates|dobj|END_ENTITY	p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elements .
15611668	0	p53	73,76	MKP1	35,39	p53	MKP1	7157	1843	Gene	Gene	Transactivates|nmod|START_ENTITY Transactivates|dobj|END_ENTITY	p53 Transactivates the phosphatase MKP1 through both intronic and exonic p53 responsive elements .
12939400	0	p53	43,46	MLH1	18,22	p53	MLH1	7157	4292	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates .
21528083	0	p53	33,36	MSH2	15,19	p53	MSH2	7157	4436	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
19797274	0	p53	14,17	MSK2	0,4	p53	MSK2	7157	8986	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	MSK2 inhibits p53 activity in the absence of stress .
15632057	0	p53	14,17	MTBP	39,43	p53	MTBP	7157	27085	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of p53 and MDM2 activity by MTBP .
23059707	0	p53	32,35	MTBP	39,43	p53	MTBP	7157	27085	Gene	Gene	enhancement|nmod|START_ENTITY enhancement|nmod|END_ENTITY	The enhancement of stability of p53 in MTBP induced p53-MDM2 regulatory network .
21297583	0	p53	36,39	MYBBP1A	56,63	p53	MYBBP1A	7157	10514	Gene	Gene	acetylation|compound|START_ENTITY acetylation|nmod|END_ENTITY	RNA content in the nucleolus alters p53 acetylation via MYBBP1A .
26044764	0	p53	49,52	MYBBP1A	83,90	p53	MYBBP1A	7157	10514	Gene	Gene	acetylation|compound|START_ENTITY acetylation|nmod|END_ENTITY	Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A .
10747965	0	p53	42,45	Maf	0,3	p53	Maf	22060(Tax:10090)	17132(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death .
14534696	0	p53	48,51	Maspin	0,6	p53	Maspin	7157	5268	Gene	Gene	outcome|compound|START_ENTITY relationship|nmod|outcome END_ENTITY|dep|relationship	Maspin in thyroid_cancer : its relationship with p53 and clinical outcome .
17174141	0	p53	92,95	Maspin	0,6	p53	Maspin	7157	5268	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Maspin expression in early oral_tongue_cancer and its relation to expression of mutant-type p53 and vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
17700520	0	p53	81,84	Maspin	32,38	p53	Maspin	22060(Tax:10090)	20724(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|dobj|transcription transcription|nmod|genes genes|amod|END_ENTITY	ATF-2 controls transcription of Maspin and GADD45_alpha genes independently from p53 to suppress mammary_tumors .
18091325	0	p53	18,21	Maspin	0,6	p53	Maspin	7157	5268	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Maspin and Mutant p53 expression in malignant_melanoma_and_carcinoma : use of tissue_microarray .
21503001	0	p53	67,70	Maspin	8,14	p53	Maspin	7157	5268	Gene	Gene	Relationship|nmod|START_ENTITY Loss|dep|Relationship Loss|nmod|Expression Expression|compound|END_ENTITY	Loss of Maspin Expression in Bladder_Cancer : Its Relationship with p53 and Clinicopathological Parameters .
12370832	0	p53	93,96	Mdm-2	0,5	p53	Mdm-2	7157	4193	Gene	Gene	Thr18|compound|START_ENTITY disruption|nmod|Thr18 regulated|nmod|disruption regulated|nsubjpass|binding binding|compound|END_ENTITY	Mdm-2 binding and TAF -LRB- II -RRB- 31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21 .
8720983	0	p53	24,27	Mdm-2	0,5	p53	Mdm-2	7157	4193	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Mdm-2 is not induced by p53 in human keratinocytes in vivo .
9371494	0	p53	80,83	Mdm-2	0,5	p53	Mdm-2	7157	4193	Gene	Gene	prevents|nmod|START_ENTITY prevents|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Mdm-2 phosphorylation by DNA-dependent_protein_kinase prevents interaction with p53 .
10202144	0	p53	33,36	Mdm2	74,78	p53	Mdm2	7157	4193	Gene	Gene	Ser20|nmod|START_ENTITY role|nmod|Ser20 role|nmod|END_ENTITY	Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 .
10202144	0	p53	67,70	Mdm2	74,78	p53	Mdm2	7157	4193	Gene	Gene	regulation|nmod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2 .
10359817	0	p53	20,23	Mdm2	68,72	p53	Mdm2	7157	4193	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|advcl|blocking blocking|dobj|shuttling shuttling|nmod|END_ENTITY	P19 -LRB- ARF -RRB- stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2 .
10781812	0	p53	55,58	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	domain|nmod|START_ENTITY binding|nmod|domain END_ENTITY|amod|binding	Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA .
10889922	0	p53	92,95	Mdm2	20,24	p53	Mdm2	7157	4193	Gene	Gene	status|compound|START_ENTITY expression|nmod|status expression|amod|END_ENTITY	Immunohistochemical Mdm2 expression in minor salivary_gland_tumours and its relationship to p53 gene status .
10892746	0	p53	104,107	Mdm2	75,79	p53	Mdm2	7157	4193	Gene	Gene	increases|nmod|START_ENTITY increases|dobj|ability ability|amod|END_ENTITY	SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53 .
10980197	0	p53	40,43	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	function|nmod|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation .
11003613	0	p53	16,19	Mdm2	79,83	p53	Mdm2	301300(Tax:10116)	314856(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY Loss|nmod|protein accompanied|nsubjpass|Loss accompanied|nmod|END_ENTITY	Loss of nuclear p53 protein in preneoplastic rat hepatocytes is accompanied by Mdm2 and Bcl-2 overexpression and by defective response to DNA damage in vivo .
11053443	0	p53	37,40	Mdm2	62,66	p53	Mdm2	7157	4193	Gene	Gene	domain|nmod|START_ENTITY role|nmod|domain role|nmod|END_ENTITY	A role for the polyproline domain of p53 in its regulation by Mdm2 .
11158620	0	p53	77,80	Mdm2	21,25	p53	Mdm2	7157	4193	Gene	Gene	switch|nmod|START_ENTITY switch|nmod|END_ENTITY	Complete switch from Mdm2 to human_papillomavirus E6-mediated degradation of p53 in cervical_cancer cells .
11328884	0	p53	111,114	Mdm2	66,70	p53	Mdm2	7157	4193	Gene	Gene	activation|compound|START_ENTITY requirement|nmod|activation alleviates|dobj|requirement alleviates|csubj|Binding Binding|dobj|site site|nmod|promoter promoter|amod|END_ENTITY	Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation .
11328884	0	p53	42,45	Mdm2	66,70	p53	Mdm2	7157	4193	Gene	Gene	Binding|nmod|START_ENTITY Binding|dobj|site site|nmod|promoter promoter|amod|END_ENTITY	Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation .
11331603	0	p53	61,64	Mdm2	33,37	p53	Mdm2	7157	4193	Gene	Gene	activation|compound|START_ENTITY role|nmod|activation phosphorylation|dep|role phosphorylation|nmod|END_ENTITY	ATM-dependent phosphorylation of Mdm2 on serine 395 : role in p53 activation by DNA damage .
11532197	0	p53	73,76	Mdm2	116,120	p53	Mdm2	7157	4193	Gene	Gene	activity|nummod|START_ENTITY increased|dobj|activity increased|advcl|decreasing decreasing|dobj|levels levels|amod|END_ENTITY	HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels .
11707453	0	p53	47,50	Mdm2	118,122	p53	Mdm2	7157	4193	Gene	Gene	accumulation|nmod|START_ENTITY Regulation|nmod|accumulation Regulation|nmod|domain domain|acl:relcl|binds binds|nmod|END_ENTITY	Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2 .
11729185	0	p53	14,17	Mdm2	23,27	p53	Mdm2	7157	4193	Gene	Gene	protects|dobj|START_ENTITY protects|nmod|END_ENTITY	PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy .
12080472	0	p53	19,22	Mdm2	0,4	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
12110584	0	p53	60,63	Mdm2	28,32	p53	Mdm2	7157	4193	Gene	Gene	regulation|compound|START_ENTITY implications|nmod|regulation phosphorylation|dep|implications phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation of Mdm2 by c-Abl : implications for p53 regulation .
12167711	0	p53	37,40	Mdm2	23,27	p53	Mdm2	7157	4193	Gene	Gene	stability|compound|START_ENTITY augments|dobj|stability augments|nsubj|Hypophosphorylation Hypophosphorylation|nmod|END_ENTITY	Hypophosphorylation of Mdm2 augments p53 stability .
12217521	0	p53	16,19	Mdm2	10,14	p53	Mdm2	7157	4193	Gene	Gene	tumor|compound|START_ENTITY PTEN|appos|tumor PTEN|appos|END_ENTITY	The PTEN , Mdm2 , p53 tumor suppressor-oncoprotein network .
12383858	0	p53	73,76	Mdm2	44,48	p53	Mdm2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY affect|dobj|degradation oncoprotein|acl:relcl|affect oncoprotein|amod|END_ENTITY	Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation .
12421820	0	p53	15,18	Mdm2	50,54	p53	Mdm2	7157	4193	Gene	Gene	Acetylation|nmod|START_ENTITY inhibits|nsubj|Acetylation inhibits|nmod|END_ENTITY	Acetylation of p53 inhibits its ubiquitination by Mdm2 .
12552135	0	p53	71,74	Mdm2	48,52	p53	Mdm2	7157	4193	Gene	Gene	regulation|compound|START_ENTITY implications|nmod|regulation lid|dep|implications lid|nmod|domain domain|nmod|END_ENTITY	Flexible lid to the p53-binding domain of human Mdm2 : implications for p53 regulation .
12586367	0	p53	37,40	Mdm2	44,48	p53	Mdm2	7157	4193	Gene	Gene	ubiquitination|nmod|START_ENTITY Differences|nmod|ubiquitination Differences|nmod|END_ENTITY	Differences in the ubiquitination of p53 by Mdm2 and the HPV protein E6 .
12600196	0	p53	55,58	Mdm2	18,22	p53	Mdm2	7157	4193	Gene	Gene	mediated|nsubj|START_ENTITY alters|ccomp|mediated alters|nsubj|Overexpression Overexpression|nmod|proteins proteins|compound|END_ENTITY	Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation , ubiquitination , and degradation .
12832478	0	p53	66,69	Mdm2	36,40	p53	Mdm2	7157	4193	Gene	Gene	ubiquitylation|nmod|START_ENTITY END_ENTITY|nmod|ubiquitylation	Critical role for a central part of Mdm2 in the ubiquitylation of p53 .
12926050	0	p53	82,85	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	act|nmod|START_ENTITY act|nsubj|mutants mutants|amod|END_ENTITY	Mdm2 ligase dead mutants did not act in a dominant negative manner to re-activate p53 , but promoted tumor cell growth .
14522887	0	p53	55,58	Mdm2	19,23	p53	Mdm2	7157	4193	Gene	Gene	unable|nmod|START_ENTITY variants|xcomp|unable variants|nsubj|promotion promotion|nmod|splice splice|amod|END_ENTITY	Tumor promotion by Mdm2 splice variants unable to bind p53 .
14654783	0	p53	65,68	Mdm2	19,23	p53	Mdm2	7157	4193	Gene	Gene	export|compound|START_ENTITY attenuation|nmod|export phosphorylation|nmod|attenuation phosphorylation|nsubj|role role|nmod|END_ENTITY	Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export .
14671306	0	p53	57,60	Mdm2	69,73	p53	Mdm2	7157	4193	Gene	Gene	control|nmod|START_ENTITY control|acl|fate fate|nmod|END_ENTITY	Mono - versus polyubiquitination : differential control of p53 fate by Mdm2 .
14673154	0	p53	15,18	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Mdm2 regulates p53 independently of p19 -LRB- ARF -RRB- in homeostatic tissues .
15013777	0	p53	14,17	Mdm2	33,37	p53	Mdm2	7157	4193	Gene	Gene	degradation|compound|START_ENTITY Inhibition|nmod|degradation Inhibition|nmod|acetylation acetylation|amod|END_ENTITY	Inhibition of p53 degradation by Mdm2 acetylation .
15150125	0	p53	21,24	Mdm2	51,55	p53	Mdm2	7157	4193	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
15150125	0	p53	86,89	Mdm2	51,55	p53	Mdm2	7157	4193	Gene	Gene	induces|dep|START_ENTITY induces|dobj|p53 p53|nmod|inhibition inhibition|nmod|END_ENTITY	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
15195100	0	p53	14,17	Mdm2	44,48	p53	Mdm2	7157	4193	Gene	Gene	stability|compound|START_ENTITY regulates|dobj|stability regulates|nmod|END_ENTITY	PML regulates p53 stability by sequestering Mdm2 to the nucleolus .
15242638	0	p53	65,68	Mdm2	26,30	p53	Mdm2	7157	4193	Gene	Gene	catalyzed|nmod|START_ENTITY catalyzed|nsubj|END_ENTITY	Neddylating the guardian ; Mdm2 catalyzed conjugation of Nedd8 to p53 .
15337531	0	p53	130,133	Mdm2	81,85	p53	Mdm2	7157	4193	Gene	Gene	function|compound|START_ENTITY increase|dobj|function mechanisms|acl:relcl|increase activation|dep|mechanisms activation|nmod|END_ENTITY	Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2 : two mechanisms that cooperatively increase p53 function in colon_cancer cells .
15337531	0	p53	54,57	Mdm2	81,85	p53	Mdm2	7157	4193	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2 : two mechanisms that cooperatively increase p53 function in colon_cancer cells .
15782125	0	p53	55,58	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	stimulating|dobj|START_ENTITY prevent|advcl|stimulating prevent|nsubj|END_ENTITY	Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation .
15782125	0	p53	77,80	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	targeting|dobj|START_ENTITY stimulating|advcl|targeting prevent|advcl|stimulating prevent|nsubj|END_ENTITY	Mdm2 and mdmX prevent ASPP1 and ASPP2 from stimulating p53 without targeting p53 for degradation .
16055726	0	p53	71,74	Mdm2	56,60	p53	Mdm2	7157	4193	Gene	Gene	abundance|compound|START_ENTITY regulates|dobj|abundance regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	Glycogen synthase kinase 3-dependent phosphorylation of Mdm2 regulates p53 abundance .
16354690	0	p53	31,34	Mdm2	49,53	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	differences|nmod|START_ENTITY inhibition|nsubj|differences inhibition|nmod|END_ENTITY	Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4 .
16455486	0	p53	0,3	Mdm2	20,24	p53	Mdm2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY ubiquitination|dep|END_ENTITY	p53 ubiquitination : Mdm2 and beyond .
16492743	0	p53	39,42	Mdm2	21,25	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	inhibition|compound|START_ENTITY roles|nmod|inhibition roles|nmod|END_ENTITY	Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development .
16866370	0	p53	73,76	Mdm2	51,55	p53	Mdm2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY essential|nmod|ubiquitination essential|nsubj|site site|nmod|domain domain|nmod|END_ENTITY	A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination .
16866370	0	p53	9,12	Mdm2	51,55	p53	Mdm2	7157	4193	Gene	Gene	site|compound|START_ENTITY site|nmod|domain domain|nmod|END_ENTITY	A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination .
16870621	0	p53	11,14	Mdm2	40,44	p53	Mdm2	7157	4193	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation .
17056014	0	p53	14,17	Mdm2	66,70	p53	Mdm2	7157	4193	Gene	Gene	response|compound|START_ENTITY response|acl|induced induced|nmod|agents agents|nmod|interaction interaction|amod|END_ENTITY	KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction .
17086174	0	p53	50,53	Mdm2	67,71	p53	Mdm2	7157	4193	Gene	Gene	regulates|dobj|START_ENTITY regulates|advcl|promoting promoting|dobj|self-ubiquitination self-ubiquitination|amod|END_ENTITY	SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination .
17170761	0	p53	17,20	Mdm2	0,4	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	JMY|compound|START_ENTITY targets|dobj|JMY targets|nsubj|END_ENTITY	Mdm2 targets the p53 transcription cofactor JMY for degradation .
17290220	0	p53	48,51	Mdm2	73,77	p53	Mdm2	7157	4193	Gene	Gene	pathway|compound|START_ENTITY regulates|dobj|pathway regulates|nmod|END_ENTITY	The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 .
17386256	0	p53	6,9	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	lifesaver|nmod:poss|START_ENTITY END_ENTITY|dep|lifesaver	Mdm2 : p53 's lifesaver ?
17525743	0	p53	44,47	Mdm2	9,13	p53	Mdm2	7157	4193	Gene	Gene	stabilization|compound|START_ENTITY involved|nmod|stabilization HAUSP|ccomp|involved HAUSP|nsubj|p53 p53|dep|END_ENTITY	The p53 -- Mdm2 -- HAUSP complex is involved in p53 stabilization by HAUSP .
17536310	0	p53	20,23	Mdm2	25,29	p53	Mdm2	7157	4193	Gene	Gene	Immunoreactivity|nmod|START_ENTITY Immunoreactivity|appos|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
17585950	0	p53	37,40	Mdm2	59,63	p53	Mdm2	7157	4193	Gene	Gene	auto|nmod|START_ENTITY switch|nmod|auto ubiquitination|nsubj|switch ubiquitination|nmod|END_ENTITY	HAUSP-regulated switch from auto - to p53 ubiquitination by Mdm2 -LRB- in silico discovery -RRB- .
17932951	0	p53	159,162	Mdm2	54,58	p53	Mdm2	7157	4193	Gene	Gene	phosphorylation|compound|START_ENTITY induces|dobj|phosphorylation induces|advcl|induces induces|xcomp|phosphorylation phosphorylation|nsubj|END_ENTITY	Anti-diol_epoxide of benzo -LSB- a -RSB- pyrene induces transient Mdm2 and p53 Ser15 phosphorylation , while anti-diol_epoxide of dibenzo -LSB- a , l -RSB- pyrene induces a nontransient p53 Ser15 phosphorylation .
17936560	0	p53	118,121	Mdm2	25,29	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY reveals|nmod|regulation reveals|nsubj|inactivation inactivation|nmod|activity activity|compound|END_ENTITY	Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation .
18483220	0	p53	35,38	Mdm2	56,60	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	instability|nmod|START_ENTITY alleviated|nsubjpass|instability alleviated|nmod|END_ENTITY	The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss .
18485798	0	p53	6,9	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	p21|compound|START_ENTITY pathways|nsubj|p21 pathways|advmod|END_ENTITY	Mdm2 , p53 , p21 and pAKT protein pathways in benign neoplasms of the salivary gland .
18541670	0	p53	68,71	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	instability|nmod|START_ENTITY promotes|dobj|instability promotes|nsubj|END_ENTITY	Mdm2 promotes genetic instability and transformation independent of p53 .
18548093	0	p53	51,54	Mdm2	68,72	p53	Mdm2	7157	4193	Gene	Gene	induction|compound|START_ENTITY prevents|dobj|induction prevents|nmod|inhibition inhibition|amod|END_ENTITY	The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML .
18567799	0	p53	38,41	Mdm2	0,4	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	activities|compound|START_ENTITY regulates|dobj|activities regulates|nsubj|END_ENTITY	Mdm2 and Mdm4 loss regulates distinct p53 activities .
18951086	0	p53	15,18	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	translation|compound|START_ENTITY regulates|dobj|translation regulates|nsubj|END_ENTITY	Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal_protein_L26 .
19160491	0	p53	18,21	Mdm2	43,47	p53	Mdm2	7157	4193	Gene	Gene	activity|compound|START_ENTITY controls|dobj|activity controls|nmod|functions functions|amod|END_ENTITY	P53 mRNA controls p53 activity by managing Mdm2 functions .
19217357	0	p53	0,3	Mdm2	22,26	p53	Mdm2	7157	4193	Gene	Gene	ubiquitination|nsubj|START_ENTITY ubiquitination|nmod|END_ENTITY	p53 ubiquitination by Mdm2 : a never ending tail ?
19244108	0	p53	45,48	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	independent|nmod|START_ENTITY affects|dobj|independent affects|nsubj|END_ENTITY	Mdm2 affects genome stability independent of p53 .
19305137	0	p53	33,36	Mdm2	65,69	p53	Mdm2	7157	4193	Gene	Gene	interaction|nmod|START_ENTITY peptide-analogue|nsubj|interaction peptide-analogue|nmod|END_ENTITY	High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx .
19619542	0	p53	14,17	Mdm2	77,81	p53	Mdm2	7157	4193	Gene	Gene	ubiquitination|compound|START_ENTITY enhances|dobj|ubiquitination enhances|advcl|altering altering|dobj|preference preference|nmod|ligase ligase|amod|END_ENTITY	Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase .
20172729	0	p53	4,7	Mdm2	19,23	p53	Mdm2	7157	4193	Gene	Gene	orchestra|compound|START_ENTITY orchestra|parataxis|set set|nsubj|END_ENTITY	The p53 orchestra : Mdm2 and Mdmx set the tone .
20479273	0	p53	36,39	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	association|nmod|START_ENTITY facilitates|dobj|association facilitates|nsubj|END_ENTITY	Mdm2 facilitates the association of p53 with the proteasome .
20528739	0	p53	18,21	Mdm2	86,90	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY Regulation|nmod|pathway Regulation|dep|problems problems|acl|studying studying|dobj|function function|nmod:poss|END_ENTITY	Regulation of the p53 tumor suppressor pathway : the problems and promises of studying Mdm2 's E3 ligase function .
20812030	0	p53	37,40	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	cells|nummod|START_ENTITY apoptosis|nmod|cells induces|dobj|apoptosis induces|nsubj|inhibition inhibition|amod|END_ENTITY	Mdm2 inhibition induces apoptosis in p53 deficient human colon_cancer cells by activating p73 - and E2F1-mediated expression of PUMA and Siva-1 .
21040902	0	p53	99,102	Mdm2	0,4	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY dampening|nmod|activity cells/progenitors|nmod|dampening survival|nmod|cells/progenitors required|nmod|survival required|nsubjpass|END_ENTITY	Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity .
21088494	0	p53	67,70	Mdm2	26,30	p53	Mdm2	7157	4193	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of regulators Mdm2 and Mdmx with transcription factors p53 , p63 and p73 .
21211512	0	p53	102,105	Mdm2	60,64	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY implication|nmod|regulation signaling|nsubj|implication maintains|parataxis|signaling maintains|dobj|expression expression|nmod|END_ENTITY	Transcription factor Nrf2 maintains the basal expression of Mdm2 : An implication of the regulation of p53 signaling by Nrf2 .
21213101	0	p53	46,49	Mdm2	0,4	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	links|nmod|START_ENTITY links|nsubj|END_ENTITY	Mdm2 links genotoxic stress and metabolism to p53 .
21217645	0	p53	14,17	Mdm2	48,52	p53	Mdm2	7157	4193	Gene	Gene	network|compound|START_ENTITY joins|dobj|network joins|dobj|loop loop|amod|END_ENTITY	miR-605 joins p53 network to form a p53 : miR-605 : Mdm2 positive feedback loop in response to stress .
21217645	0	p53	36,39	Mdm2	48,52	p53	Mdm2	7157	4193	Gene	Gene	form|dobj|START_ENTITY joins|xcomp|form joins|dobj|loop loop|amod|END_ENTITY	miR-605 joins p53 network to form a p53 : miR-605 : Mdm2 positive feedback loop in response to stress .
21420949	0	p53	20,23	Mdm2	36,40	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching .
21572037	0	p53	52,55	Mdm2	30,34	p53	Mdm2	7157	4193	Gene	Gene	polyubiquitination|compound|START_ENTITY polyubiquitination|amod|END_ENTITY	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination .
21730132	0	p53	63,66	Mdm2	22,26	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulating|dobj|activity critical|advcl|regulating critical|nsubj|Heterodimerization Heterodimerization|nmod|END_ENTITY	Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability .
21762075	0	p53	16,19	Mdm2	34,38	p53	Mdm2	7157	4193	Gene	Gene	START_ENTITY|acl|inhibiting inhibiting|xcomp|ligase ligase|nsubj|E3 E3|compound|END_ENTITY	Reactivation of p53 by inhibiting Mdm2 E3 ligase : a novel antitumor approach .
22134240	0	p53	0,3	Mdm2	49,53	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY regulation|dep|teamwork teamwork|acl|RING RING|dobj|domains domains|nmod|END_ENTITY	p53 regulation : teamwork between RING domains of Mdm2 and MdmX .
22148351	0	p53	25,28	Mdm2	46,50	p53	Mdm2	7157	4193	Gene	Gene	Structure|nmod|START_ENTITY peptide|nsubj|Structure peptide|xcomp|bound bound|nmod|END_ENTITY	Structure of the stapled p53 peptide bound to Mdm2 .
22197810	0	p53	70,73	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	inhibition|compound|START_ENTITY antagonized|nmod|inhibition activator|acl:relcl|antagonized activator|nsubj|END_ENTITY	Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition .
22264786	0	p53	4,7	Mdm2	39,43	p53	Mdm2	7157	4193	Gene	Gene	interaction|compound|START_ENTITY controls|nsubj|interaction controls|dobj|trafficking trafficking|amod|END_ENTITY	The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage .
22301280	0	p53	63,66	Mdm2	30,34	p53	Mdm2	7157	4193	Gene	Gene	stabilize|dobj|START_ENTITY stabilize|nsubj|molecules molecules|acl:relcl|bind bind|dobj|RING RING|amod|END_ENTITY	Small molecules that bind the Mdm2 RING stabilize and activate p53 .
22333590	0	p53	124,127	Mdm2	103,107	p53	Mdm2	7157	4193	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers .
22333590	0	p53	124,127	Mdm2	23,27	p53	Mdm2	7157	4193	Gene	Gene	activity|nmod|START_ENTITY suggests|nmod|activity suggests|nsubj|analysis analysis|nmod|tail tail|amod|END_ENTITY	Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers .
22410433	0	p53	14,17	Mdm2	43,47	p53	Mdm2	7157	4193	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|collaboration collaboration|nmod|END_ENTITY	Regulation of p53 : a collaboration between Mdm2 and Mdmx .
22487680	0	p53	4,7	Mdm2	48,52	p53	Mdm2	7157	4193	Gene	Gene	isoforms|compound|START_ENTITY modified|nsubjpass|isoforms modified|nmod|END_ENTITY	The p53 isoforms are differentially modified by Mdm2 .
22659184	0	p53	83,86	Mdm2	43,47	p53	Mdm2	7157	4193	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability domain|nmod|regulation domain|amod|END_ENTITY	Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability .
22666487	0	p53	28,31	Mdm2	0,4	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|mutation mutation|compound|END_ENTITY	Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction .
22673503	0	p53	34,37	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	regulate|dobj|START_ENTITY partner|acl|regulate partner|compound|END_ENTITY	Mdm2 and MdmX partner to regulate p53 .
24476585	0	p53	130,133	Mdm2	139,143	p53	Mdm2	7157	4193	Gene	Gene	interaction|nmod|START_ENTITY targeting|dobj|interaction targeting|nmod|END_ENTITY	The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells : targeting the interaction of p53 with Mdm2 and Mdm4 .
25117711	0	p53	14,17	Mdm2	21,25	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	START_ENTITY|nmod|function function|compound|END_ENTITY	Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development , but essential in response to DNA damage .
25486483	0	p53	104,107	Mdm2	155,159	p53	Mdm2	7157	4193	Gene	Gene	gastric_cancer|nmod|START_ENTITY suppressor|nmod|gastric_cancer functions|nmod|suppressor functions|parataxis|signaling signaling|nsubj|END_ENTITY	Epithelial cell-derived periostin functions as a tumor suppressor in gastric_cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF / Mdm2 signaling pathway .
25637791	0	p53	34,37	Mdm2	62,66	p53	Mdm2	7157	4193	Gene	Gene	stability|compound|START_ENTITY decreases|dobj|stability decreases|advcl|regulating regulating|dobj|activity activity|amod|END_ENTITY	Heat_shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver_cancer .
25746004	0	p53	28,31	Mdm2	47,51	p53	Mdm2	30590(Tax:7955)	30637(Tax:7955)	Gene	Gene	signaling|nmod|START_ENTITY Tumor-specific|acl|signaling mimicked|nsubjpass|Tumor-specific mimicked|nmod|inactivation inactivation|amod|END_ENTITY	Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish : insights from mdm2 and mdm4 mutant zebrafish .
9153395	0	p53	39,42	Mdm2	0,4	p53	Mdm2	7157	4193	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	Mdm2 promotes the rapid degradation of p53 .
9153396	0	p53	14,17	Mdm2	31,35	p53	Mdm2	7157	4193	Gene	Gene	stability|compound|START_ENTITY Regulation|nmod|stability Regulation|nmod|END_ENTITY	Regulation of p53 stability by Mdm2 .
9458382	0	p53	65,68	Mdm2	35,39	p53	Mdm2	7157	4193	Gene	Gene	positivity|compound|START_ENTITY enhanced|nmod|positivity enhanced|nsubjpass|relevance relevance|nmod|detection detection|amod|END_ENTITY	Prognostic relevance of C-terminal Mdm2 detection is enhanced by p53 positivity in soft tissue_sarcomas .
9824166	0	p53	22,25	Mdm2	0,4	p53	Mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Mdm2 association with p53 targets its ubiquitination .
9878046	0	p53	98,101	Mdm2	29,33	p53	Mdm2	7157	4193	Gene	Gene	Mdm2|nmod|START_ENTITY activity|nmod|Mdm2 inhibits|dobj|activity inhibits|nsubj|Association Association|nmod|p19 p19|nmod|END_ENTITY	Association of p19 -LRB- ARF -RRB- with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 .
10629057	0	p53	14,17	MdmX	0,4	p53	MdmX	7157	4194	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	MdmX protects p53 from Mdm2-mediated degradation .
16227609	0	p53	67,70	MdmX	38,42	p53	MdmX	7157	4194	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation .
16227609	0	p53	67,70	MdmX	84,88	p53	MdmX	7157	4194	Gene	Gene	activates|dobj|START_ENTITY activates|advcl|targeting targeting|dobj|END_ENTITY	DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation .
19153082	0	p53	56,59	MdmX	28,32	p53	MdmX	7157	4194	Gene	Gene	Changes|nummod|START_ENTITY Complex|nmod|Changes Structures|nmod|Complex Structures|nmod|END_ENTITY	Crystal Structures of Human MdmX -LRB- HdmX -RRB- in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes .
20174603	0	p53	59,62	MdmX	23,27	p53	MdmX	7157	4194	Gene	Gene	response|nmod|START_ENTITY fine-tuning|dobj|response fine-tuning|nsubj|functions functions|nmod|END_ENTITY	Predicted functions of MdmX in fine-tuning the response of p53 to DNA damage .
21572037	0	p53	52,55	MdmX	0,4	p53	MdmX	7157	4194	Gene	Gene	polyubiquitination|compound|START_ENTITY essential|nmod|polyubiquitination essential|nsubj|protein protein|compound|END_ENTITY	MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination .
21852537	0	p53	60,63	MdmX	14,18	p53	MdmX	22060(Tax:10090)	17248(Tax:10090)	Gene	Gene	Validation|nmod|START_ENTITY Validation|nmod|END_ENTITY	Validation of MdmX as a therapeutic target for reactivating p53 in tumors .
22290440	0	p53	21,24	MdmX	0,4	p53	MdmX	7157	4194	Gene	Gene	interaction|compound|START_ENTITY required|nmod|interaction required|nsubjpass|END_ENTITY	MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress .
22989451	0	p53	114,117	MdmX	104,108	p53	MdmX	7157	4194	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|dobj|interaction interaction|nmod|END_ENTITY	A fluorescent-based high-throughput screening assay for small molecules that inhibit the interaction of MdmX with p53 .
11606419	0	p53	16,19	Mdmx	0,4	p53	Mdmx	7157	4194	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms .
15199139	0	p53	86,89	Mdmx	17,21	p53	Mdmx	7157	4194	Gene	Gene	activity|compound|START_ENTITY inhibiting|dobj|activity contributes|advcl|inhibiting contributes|nsubj|Amplification Amplification|nmod|END_ENTITY	Amplification of Mdmx -LRB- or Mdm4 -RRB- directly contributes to tumor formation by inhibiting p53 tumor suppressor activity .
15865931	0	p53	34,37	Mdmx	0,4	p53	Mdmx	22060(Tax:10090)	17248(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Mdmx as an essential regulator of p53 activity .
17938582	0	p53	38,41	Mdmx	45,49	p53	Mdmx	7157	4194	Gene	Gene	inhibition|nmod|START_ENTITY basis|nmod|inhibition basis|nmod|END_ENTITY	Molecular basis for the inhibition of p53 by Mdmx .
18677113	0	p53	49,52	Mdmx	23,27	p53	Mdmx	7157	4194	Gene	Gene	domain|compound|START_ENTITY bound|nmod|domain bound|nsubj|Structure Structure|nmod|protein protein|compound|END_ENTITY	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain .
19432880	0	p53	63,66	Mdmx	70,74	p53	Mdmx	7157	4194	Gene	Gene	inhibition|nmod|START_ENTITY involved|nmod|inhibition involved|nmod|END_ENTITY	Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2 .
19619542	0	p53	14,17	Mdmx	0,4	p53	Mdmx	7157	4194	Gene	Gene	ubiquitination|compound|START_ENTITY enhances|dobj|ubiquitination enhances|nsubj|END_ENTITY	Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase .
23277204	0	p53	31,34	Mdmx	82,86	p53	Mdmx	7157	4194	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|dephosphorylating dephosphorylating|dobj|END_ENTITY	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx .
24608433	0	p53	49,52	Mdmx	0,4	p53	Mdmx	7157	4194	Gene	Gene	independent|nmod|START_ENTITY promotes|dobj|independent promotes|nsubj|END_ENTITY	Mdmx promotes genomic instability independent of p53 and Mdm2 .
24667108	0	p53	106,109	Mdmx	17,21	p53	Mdmx	7157	4194	Gene	Gene	mutations|compound|START_ENTITY substituting|nmod|mutations mammary|advcl|substituting contribute|xcomp|mammary contribute|nsubj|Amplification Amplification|nmod|END_ENTITY	Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations .
26181202	0	p53	54,57	Mdmx	10,14	p53	Mdmx	7157	4194	Gene	Gene	treat|nmod|START_ENTITY Targeting|xcomp|treat Targeting|dobj|END_ENTITY	Targeting Mdmx to treat breast_cancers with wild-type p53 .
20386864	0	p53	28,31	MicroRNA-34a	0,12	p53	MicroRNA-34a	22060(Tax:10090)	723848(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	MicroRNA-34a is induced via p53 during cisplatin nephrotoxicity and contributes to cell survival .
24623309	0	p53	32,35	MicroRNA-34a	0,12	p53	MicroRNA-34a	22060(Tax:10090)	723848(Tax:10090)	Gene	Gene	function|compound|START_ENTITY dispensable|nmod|function dispensable|nsubj|END_ENTITY	MicroRNA-34a is dispensable for p53 function as teratogenesis inducer .
17823410	0	p53	45,48	MicroRNA-34b	0,12	p53	MicroRNA-34b	7157	407041	Gene	Gene	targets|nmod|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth .
16024796	0	p53	79,82	Mitochondrial_ribosomal_protein_L41	0,35	p53	Mitochondrial ribosomal protein L41	22060(Tax:10090)	107733(Tax:10090)	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Mitochondrial_ribosomal_protein_L41 suppresses cell growth in association with p53 and p27Kip1 .
20804729	0	p53	40,43	Mitofusin-2	0,11	p53	Mitofusin-2	7157	9927	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Mitofusin-2 is a novel direct target of p53 .
16778175	0	p53	80,83	Mitogen-activated_protein_kinase_phosphatase_2	0,46	p53	Mitogen-activated protein kinase phosphatase 2	7157	1846	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Mitogen-activated_protein_kinase_phosphatase_2 : a novel transcription target of p53 in apoptosis .
20712406	0	p53	54,57	MnSOD	8,13	p53	MnSOD	7157	6648	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of MnSOD and p66shc in mitochondrial response to p53 .
20186124	0	p53	54,57	Mos	76,79	p53	Mos	7157	4342	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Multipolar mitosis of tetraploid cells : inhibition by p53 and dependency on Mos .
12902982	0	p53	20,23	Myc	0,3	p53	Myc	7157	4609	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts .
22446994	0	p53	32,35	Myc	49,52	p53	Myc	22060(Tax:10090)	17869(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|nmod|END_ENTITY	Potential synergism of Bim with p53 in mice with Myc - induced lymphoma in a mouse_lymphoma model .
15861129	0	p53	36,39	Myeloid_leukemia_factor_1	0,25	p53	Myeloid leukemia factor 1	7157	4291	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Myeloid_leukemia_factor_1 regulates p53 by suppressing COP1 via COP9_signalosome_subunit_3 .
8590759	0	p53	20,23	N-RAS	116,121	p53	N-RAS	7157	4893	Gene	Gene	effect|nmod|START_ENTITY transformed|nsubj|effect transformed|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Opposite effect of p53 on nucleotide metabolizing enzyme activity in Rat1 cells and their sublines , transformed by N-RAS or v-mos oncogenes -RSB- .
10192423	0	p53	103,106	N-ras	68,73	p53	N-ras	7157	4893	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Molecular evolution of acute_myeloid_leukaemia in relapse : unstable N-ras and FLT3 genes compared with p53 gene .
11172613	0	p53	30,33	N-ras	23,28	p53	N-ras	7157	4893	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|compound|END_ENTITY	Mutational analysis of N-ras , p53 , p16INK4a , p14ARF and CDK4 genes in primary human malignant mesotheliomas .
8217795	0	p53	33,36	N-ras	123,128	p53	N-ras	7157	4893	Gene	Gene	gene|compound|START_ENTITY mutations|nmod|gene Occurrence|nmod|mutations increased|nsubjpass|Occurrence increased|xcomp|carrying carrying|dobj|mutation mutation|compound|END_ENTITY	Occurrence of point mutations in p53 gene is not increased in patients with acute_myeloid_leukaemia carrying an activating N-ras mutation .
23683786	0	p53	179,182	NANOG	39,44	p53	NANOG	7157	79923	Gene	Gene	cells|nmod|START_ENTITY leads|nmod|cells leads|nsubj|silencing silencing|nmod|END_ENTITY	RNA interference-mediated silencing of NANOG leads to reduced proliferation and self-renewal , cell cycle arrest and apoptosis in T-cell_acute_lymphoblastic_leukemia cells via the p53 signaling pathway .
26882543	0	p53	16,19	NAT10	0,5	p53	NAT10	7157	55226	Gene	Gene	activation|compound|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2 .
26324937	0	p53	12,15	NDRG1	0,5	p53	NDRG1	7157	10397	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability .
26324937	0	p53	12,15	NDRG1	0,5	p53	NDRG1	7157	10397	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability .
15073170	0	p53	0,3	NF-kappaB	12,21	p53	NF-kappaB	7157	4790	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|amod|END_ENTITY	p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal_S6_kinase_1 .
17132229	0	p53	15,18	NF-kappaB	22,31	p53	NF-kappaB	7157	4790	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma .
11783085	0	p53	39,42	NF-kappa_B	58,68	p53	NF-kappa B	7157	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	-LSB- EBV latent_membrane_protein_1 induces p53 expression via NF-kappa_B in nasopharyngeal_carcinoma -RSB- .
12887889	0	p53	0,3	NF-kappa_B	40,50	p53	NF-kappa B	7157	4790	Gene	Gene	repression|amod|START_ENTITY repression|nmod|END_ENTITY	p53 - and Mdm2-independent repression of NF-kappa_B transactivation by the ARF_tumor suppressor .
17215959	0	p53	15,18	NF-kappa_B	22,32	p53	NF-kappa B	7157	4790	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling from p53 to NF-kappa_B determines the chemotherapy responsiveness of neuroblastoma .
17499812	0	p53	78,81	NF-kappa_B	102,112	p53	NF-kappa B	7157	4790	Gene	Gene	induction|nmod|START_ENTITY mediated|nmod|induction pathways|ccomp|mediated pathways|nsubj|down-regulation down-regulation|nmod|kinases kinases|compound|END_ENTITY	Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53 , down-regulation of NF-kappa_B and mitogen-activated protein kinases pathways .
21054790	0	p53	92,95	NF-kappa_B	114,124	p53	NF-kappa B	7157	4790	Gene	Gene	START_ENTITY|nmod|pathways pathways|amod|END_ENTITY	Fisetin , a dietary flavonoid , induces cell cycle arrest and apoptosis through activation of p53 and inhibition of NF-kappa_B pathways in bladder_cancer cells .
8051093	0	p53	25,28	NF-kappa_B	0,10	p53	NF-kappa B	7157	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappa_B activation of p53 .
16244358	0	p53	118,121	NFkappaB	144,152	p53	NFkappaB	22060(Tax:10090)	18033(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|activation activation|compound|END_ENTITY	Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation : role of p38 MAP kinase .
17916563	0	p53	68,71	NM23-H1	0,7	p53	NM23-H1	7157	4830	Gene	Gene	function|compound|START_ENTITY STRAP|dobj|function STRAP|nsubj|suppressor suppressor|compound|END_ENTITY	NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function .
11867746	0	p53	16,19	NQO1	0,4	p53	NQO1	7157	1728	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	NQO1 stabilizes p53 through a distinct pathway .
11602746	0	p53	72,75	NS1	0,3	p53	NS1	7157	1489590(Tax:10794)	Gene	Gene	involvement|nmod|START_ENTITY cell|dep|involvement cell|amod|END_ENTITY	NS1 - and minute_virus_of_mice-induced cell cycle arrest : involvement of p53 and p21 -LRB- cip1 -RRB- .
23954291	0	p53	29,32	NS1	10,13	p53	NS1	7157	5781	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes , in a promoter-dependent manner .
16380082	0	p53	60,63	NS3	107,110	p53	NS3	7157	3845	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Single-point mutations of hepatitis_C_virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3 .
16380082	0	p53	60,63	NS3	44,47	p53	NS3	7157	3845	Gene	Gene	interaction|compound|START_ENTITY END_ENTITY|dobj|interaction	Single-point mutations of hepatitis_C_virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3 .
16690937	0	p53	71,74	NS3	0,3	p53	NS3	7157	3845	Gene	Gene	associates|nmod|START_ENTITY associates|nsubj|protein protein|nummod|END_ENTITY	NS3 protein of Hepatitis_C_virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner .
9016797	0	p53	32,35	NS3	73,76	p53	NS3	7157	3845	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|accumulation accumulation|nmod|protein protein|compound|END_ENTITY	Wild-type , but not mutant-type , p53 enhances nuclear accumulation of the NS3 protein of hepatitis_C_virus .
18690848	0	p53	21,24	NUPR1	0,5	p53	NUPR1	7157	26471	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	NUPR1 interacts with p53 , transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic_stress .
15619621	0	p53	0,3	Nanog	73,78	p53	Nanog	22060(Tax:10090)	71950(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|advcl|suppressing suppressing|dobj|expression expression|compound|END_ENTITY	p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression .
23651583	0	p53	67,70	Nanog	57,62	p53	Nanog	7157	79923	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells .
24333425	0	p53	13,16	Nanog	28,33	p53	Nanog	22060(Tax:10090)	71950(Tax:10090)	Gene	Gene	Knockdown|nmod|START_ENTITY suppresses|nsubj|Knockdown suppresses|xcomp|END_ENTITY	Knockdown of p53 suppresses Nanog expression in embryonic stem cells .
11861836	0	p53	66,69	Nef	36,39	p53	Nef	7157	6285	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis .
14729959	0	p53	21,24	Net	34,37	p53	p53	7157	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	The tumor suppressor p53 inhibits Net , an effector of Ras/extracellular signal-regulated kinase signaling .
23690620	0	p53	23,26	Ninjurin1	0,9	p53	Ninjurin1	7157	4814	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Ninjurin1 , a target of p53 , regulates p53 expression and p53-dependent cell survival , senescence , and radiation-induced mortality .
23690620	0	p53	38,41	Ninjurin1	0,9	p53	Ninjurin1	7157	4814	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ninjurin1 , a target of p53 , regulates p53 expression and p53-dependent cell survival , senescence , and radiation-induced mortality .
10049778	0	p53	126,129	Nip3	118,122	p53	Nip3	22060(Tax:10090)	12176(Tax:10090)	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Effects of wild-type and mutated p53 and Id proteins on the induction of apoptosis by adenovirus E1A , c-Myc , Bax , and Nip3 in p53 null mouse cerebellum cells .
18359760	0	p53	80,83	Notch-1	0,7	p53	Notch-1	7157	4851	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Notch-1 regulates transcription of the epidermal_growth_factor_receptor through p53 .
21743969	0	p53	29,32	Notch-1	0,7	p53	Notch-1	7157	4851	Gene	Gene	restoration|compound|START_ENTITY restoration|nummod|END_ENTITY	Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells .
14991602	0	p53	0,3	Notch1	21,27	p53	Notch1	22059(Tax:10090)	18128(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activation activation|amod|END_ENTITY	p53 regulates thymic Notch1 activation .
16651424	0	p53	91,94	Notch1	22,28	p53	Notch1	7157	4851	Gene	Gene	inhibition|nmod|START_ENTITY signaling|dep|inhibition signaling|nmod|END_ENTITY	Survival signaling by Notch1 : mammalian_target_of_rapamycin -LRB- mTOR -RRB- - dependent inhibition of p53 .
17186020	0	p53	32,35	Notch1	10,16	p53	Notch1	7157	4851	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Activated Notch1 interacts with p53 to inhibit its phosphorylation and transactivation .
17237812	0	p53	0,3	Notch1	90,96	p53	Notch1	22060(Tax:10090)	18128(Tax:10090)	Gene	Gene	homologue|compound|START_ENTITY maintains|nsubj|homologue maintains|advcl|inhibiting inhibiting|dobj|activity activity|amod|END_ENTITY	p53 homologue , p51/p63 , maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity .
17344417	0	p53	12,15	Notch1	0,6	p53	Notch1	7157	4851	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases .
17353266	0	p53	40,43	Notch1	14,20	p53	Notch1	7157	4851	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of Notch1 gene expression by p53 in epithelial cells .
17534448	0	p53	15,18	Notch1	87,93	p53	Notch1	7157	4851	Gene	Gene	expression|compound|START_ENTITY Restoration|nmod|expression upregulates|nsubj|Restoration upregulates|dobj|expression expression|nmod|END_ENTITY	Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1 : implications for cancer_cell_fate_determination after genotoxic stress .
18049480	0	p53	214,217	Notch1	139,145	p53	Notch1	7157	4851	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|effects effects|amod|END_ENTITY	Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53 .
19376776	0	p53	174,177	Notch1	0,6	p53	Notch1	7157	4851	Gene	Gene	degradation|compound|START_ENTITY inhibiting|dobj|degradation sensitizes|advcl|inhibiting sensitizes|nsubj|signaling signaling|compound|END_ENTITY	Notch1 signaling sensitizes tumor_necrosis_factor-related_apoptosis-inducing_ligand-induced apoptosis in human hepatocellular_carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression .
21480340	0	p53	56,59	Notch1	0,6	p53	Notch1	7157	4851	Gene	Gene	overexpression|compound|START_ENTITY regulates|nmod|overexpression regulates|nsubj|END_ENTITY	Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular_carcinoma .
23943799	0	p53	93,96	Notch1	0,6	p53	Notch1	7157	4851	Gene	Gene	lung_adenocarcinoma|nmod|START_ENTITY required|nmod|lung_adenocarcinoma required|nsubjpass|END_ENTITY	Notch1 is required for Kras-induced lung_adenocarcinoma and controls_tumor cell survival via p53 .
24621507	0	p53	75,78	Nuclear_interactor_of_ARF_and_Mdm2	0,34	p53	Nuclear interactor of ARF and Mdm2	7157	84897;4193	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Nuclear_interactor_of_ARF_and_Mdm2 regulates multiple pathways to activate p53 .
12080348	0	p53	70,73	Nucleophosmin	0,13	p53	Nucleophosmin	7157	4869	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Nucleophosmin regulates the stability and transcriptional activity of p53 .
19671681	0	p53	52,55	Nurr1	31,36	p53	Nurr1	7157	4929	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	NGFI-B nuclear orphan receptor Nurr1 interacts with p53 and suppresses its transcriptional activity .
12503076	0	p53	147,150	O6-methylguanine-DNA_methyltransferase	16,54	p53	O6-methylguanine-DNA methyltransferase	7157	4255	Gene	Gene	mutations|nmod|START_ENTITY END_ENTITY|dep|mutations	DNA repair gene O6-methylguanine-DNA_methyltransferase : promoter hypermethylation associated with decreased expression and G : C to A : T mutations of p53 in brain_tumors .
12807758	0	p53	120,123	O6-methylguanine-DNA_methyltransferase	32,70	p53	O6-methylguanine-DNA methyltransferase	7157	4255	Gene	Gene	mutations|compound|START_ENTITY repair|nmod|mutations repair|dobj|END_ENTITY	Inactivation of DNA repair gene O6-methylguanine-DNA_methyltransferase by promoter hypermethylation and its relation to p53 mutations in esophageal_squamous_cell_carcinoma .
17234766	0	p53	53,56	O6-methylguanine-DNA_methyltransferase	0,38	p53	O6-methylguanine-DNA methyltransferase	22060(Tax:10090)	17314(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	O6-methylguanine-DNA_methyltransferase regulation by p53 in astrocytic cells .
18712569	0	p53	87,90	O6-methylguanine-DNA_methyltransferase	15,53	p53	O6-methylguanine-DNA methyltransferase	7157	4255	Gene	Gene	occurrence|compound|START_ENTITY promoter|nmod|occurrence promoter|nsubj|Association Association|nmod|END_ENTITY	Association of O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- promoter methylation with p53 mutation occurrence in non-small cell lung_cancer with different histology , gender , and smoking status .
8616846	0	p53	10,13	O6-methylguanine-DNA_methyltransferase	52,90	p53	O6-methylguanine-DNA methyltransferase	7157	4255	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA_methyltransferase gene .
9780001	0	p53	0,3	O6-methylguanine-DNA_methyltransferase	53,91	p53	O6-methylguanine-DNA methyltransferase	301300(Tax:10116)	25332(Tax:10116)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|END_ENTITY	p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA_methyltransferase -LRB- MGMT -RRB- by DNA damaging agents .
22124327	0	p53	23,26	Otubain_1	81,90	p53	Otubain 1	7157	55611	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability regulation|nmod|END_ENTITY	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain_1 .
9988237	0	p53	45,48	P-glycoprotein	0,14	p53	P-glycoprotein	7157	5243	Gene	Gene	correlated|nmod|START_ENTITY correlated|nsubjpass|END_ENTITY	P-glycoprotein is positively correlated with p53 in human oral pre-malignant and malignant lesions and is associated with poor prognosis .
12612901	0	p53	98,101	P14	0,3	p53	P14	7157	11102	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|methylation methylation|nummod|END_ENTITY	P14 methylation in human colon_cancer is associated with microsatellite_instability and wild-type p53 .
8732090	0	p53	81,84	P21	32,35	p53	P21	7157	644914	Gene	Gene	genes|compound|START_ENTITY Detection|appos|genes Detection|nmod|expression expression|nmod|END_ENTITY	-LSB- Detection of the expression of P21 , P53 , P185 proteins and the mutation of ras , p53 genes in colorectal_adenoma_and_carcinoma -RSB- .
9275651	0	p53	116,119	P21	71,74	p53	P21	7157	644914	Gene	Gene	genes|compound|START_ENTITY ras|appos|genes significance|nmod|ras significance|nmod|expression expression|nmod|END_ENTITY	-LSB- Detection and clinical pathological significance of the expression of P21 , P185 , p53 proteins and mutation of ras , p53 genes in transitional cell carcinoma_of_the_bladder -RSB- .
15188025	0	p53	126,129	P27	24,27	p53	P27	7157	3429	Gene	Gene	expression|compound|START_ENTITY correlation|nmod|expression atypia|dep|correlation complex_hyperplasia|nmod|atypia decreased|advcl|complex_hyperplasia decreased|dobj|expression expression|compound|END_ENTITY	Significantly decreased P27 expression in endometrial_carcinoma compared to complex_hyperplasia with atypia -LRB- correlation with p53 expression -RRB- .
11480026	0	p53	32,35	P53	51,54	p53	P53	7157	7157	Gene	Gene	staining|compound|START_ENTITY staining|dep|END_ENTITY	-LSB- A study on the significance of p53 gene mutation , P53 protein positive staining and PCNA staining -RSB- .
11920641	0	p53	62,65	P53R2	36,41	p53	P53R2	7157	50484	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	Expression and mutation analyses of P53R2 , a newly identified p53 target for DNA repair in human gastric_carcinoma .
16619496	0	p53	7,10	P53R2	0,5	p53	P53R2	7157	50484	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	P53R2 , p53 inducible ribonucleotide reductase gene , correlated with tumor progression of non-small cell lung_cancer .
11536043	0	p53	130,133	P73	0,3	p53	P73	7157	7161	Gene	Gene	concert|nmod|START_ENTITY role|nmod|concert expression|dep|role expression|nummod|END_ENTITY	P73 expression in basal layers of head_and_neck_squamous_epithelium : a role in differentiation and carcinogenesis in concert with p53 and p63 ?
15849742	0	p53	26,29	P73	0,3	p53	P73	7157	7161	Gene	Gene	replaces|dobj|START_ENTITY replaces|nsubj|END_ENTITY	P73 functionally replaces p53 in Adriamycin-treated , p53-deficient breast_cancer cells .
17470788	0	p53	32,35	PACT	0,4	p53	PACT	22060(Tax:10090)	19647(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	PACT is a negative regulator of p53 and essential for cell growth and embryonic development .
9010216	0	p53	49,52	PACT	0,4	p53	PACT	7157	5930	Gene	Gene	protein|compound|START_ENTITY cloning|nmod|protein END_ENTITY|dep|cloning	PACT : cloning and characterization of a cellular p53 binding protein that interacts with Rb .
12358742	0	p53	51,54	PARP-1	58,64	p53	PARP-1	7157	142	Gene	Gene	modification|nmod|START_ENTITY novel|nmod|modification novel|nmod|END_ENTITY	A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism .
20067769	0	p53	171,174	PARP-1	121,127	p53	PARP-1	7157	142	Gene	Gene	pathway|compound|START_ENTITY re-activation|nmod|pathway topoisomerase|nmod|re-activation topoisomerase|nmod|results results|compound|END_ENTITY	Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints .
22395446	0	p53	114,117	PARP-1	107,113	p53	PARP-1	22060(Tax:10090)	11545(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular_carcinoma apoptosis via PARP-1 / p53 pathway .
24323920	1	p53	43,46	PARP-1	57,63	p53	PARP-1	7157	142	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|necrosis necrosis|amod|dependent dependent|amod|END_ENTITY	Let me count the ways : p53 regulates PARP-1 dependent necrosis .
25182801	0	p53	10,13	PARP-1	73,79	p53	PARP-1	7157	142	Gene	Gene	activity|compound|START_ENTITY activity|nmod|sensitivity sensitivity|nmod|cells cells|nmod|END_ENTITY	Effect of p53 activity on the sensitivity of human glioblastoma cells to PARP-1 inhibitor in combination with topoisomerase i inhibitor or radiation .
22052190	0	p53	108,111	PATZ1	54,59	p53	PATZ1	7157	23598	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|and_AT-hook-containing_zinc_finger_protein_1 and_AT-hook-containing_zinc_finger_protein_1|appos|END_ENTITY	POZ/BTB _ and_AT-hook-containing_zinc_finger_protein_1 -LRB- PATZ1 -RRB- inhibits endothelial cell senescence through a p53 dependent pathway .
24336083	0	p53	21,24	PATZ1	0,5	p53	PATZ1	22060(Tax:10090)	56218(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context .
25755280	0	p53	68,71	PATZ1	0,5	p53	PATZ1	7157	23598	Gene	Gene	function|compound|START_ENTITY inhibits|dobj|function factor|acl:relcl|inhibits factor|nsubj|END_ENTITY	PATZ1 is a DNA damage responsive transcription factor that inhibits p53 function .
25408419	0	p53	29,32	PBF	19,22	p53	PBF	7157	754	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal_cancer .
9840345	0	p53	62,65	PC3	106,109	p53	PC3	7157	57332	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Role of superoxide anion on the proliferation and c-Ha-ras or p53 expression in prostate_cancer cell line PC3 .
17785449	0	p53	14,17	PC4	64,67	p53	PC4	7157	10923	Gene	Gene	function|compound|START_ENTITY function|nmod|END_ENTITY	Activation of p53 function by human transcriptional coactivator PC4 : role of protein-protein interaction , DNA bending , and posttranslational modifications .
25590240	0	p53	16,19	PCDH10	0,6	p53	PCDH10	7157	57575	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	PCDH10 , a novel p53 transcriptional target in regulating cell migration .
10347785	0	p53	12,15	PCNA	62,66	p53	PCNA	7157	5111	Gene	Gene	expression|compound|START_ENTITY expression|acl|using using|dobj|END_ENTITY	Analysis of p53 expression and proliferative assessment using PCNA in localized prostate_carcinoma .
11019942	0	p53	0,3	PCNA	16,20	p53	PCNA	7157	5111	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	p53 , cyclin-D1 , PCNA , AgNOR expression in squamous_cell_cancer_of_the_lip : a multicenter study .
11451553	0	p53	50,53	PCNA	55,59	p53	PCNA	7157	5111	Gene	Gene	START_ENTITY|dep|MI MI|compound|END_ENTITY	The importance of biological factors -LRB- bcl-2 , bax , p53 , PCNA , MI , HPV and angiogenesis -RRB- in invasive cervical_cancer .
12217864	0	p53	30,33	PCNA	22,26	p53	PCNA	7157	5111	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	Spatial repression of PCNA by p53 during kidney development .
12760717	0	p53	62,65	PCNA	56,60	p53	PCNA	7157	5111	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Helicobacter_pylori_infection affects the expression of PCNA , p53 , c-erbB-2 and Bcl-2 in the human gastric mucosa .
12763212	0	p53	34,37	PCNA	46,50	p53	PCNA	7157	5111	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
12807244	0	p53	168,171	PCNA	215,219	p53	PCNA	7157	5111	Gene	Gene	pRb|dep|START_ENTITY correlation|nmod|pRb correlation|appos|END_ENTITY	Immunohistochemical expression of heat_shock protein 27 , in normal hyperplastic and neoplastic endometrium : correlation with estrogen and progesterone_receptor status , p53 , pRb and proliferation associated indices -LRB- PCNA , MIB1 -RRB- .
12854173	0	p53	21,24	PCNA	15,19	p53	PCNA	7157	5111	Gene	Gene	Expressions|appos|START_ENTITY Expressions|nmod|END_ENTITY	Expressions of PCNA , p53 , p21 -LRB- WAF-1 -RRB- and cell proliferation in fetal esophageal epithelia : comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal_cancer in Henan , _ North_China .
14598611	0	p53	146,149	PCNA	115,119	p53	PCNA	7157	5111	Gene	Gene	genes|dep|START_ENTITY correlation|appos|genes correlation|appos|Ki67 Ki67|dep|END_ENTITY	Immunohistochemical study of apoptosis-related Bcl-2 protein and its correlation with proliferation indices -LRB- Ki67 , PCNA -RRB- , tumor suppressor genes -LRB- p53 , pRb -RRB- , the oncogene c-erbB-2 , sex steroid hormone receptors and other clinicopathological features , in normal , hyperplastic and neoplastic endometrium .
14658589	1	p53	137,140	PCNA	193,197	p53	PCNA	7157	5111	Gene	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	An immunohistochemical study including correlations with p53 , steroid receptor status and proliferative indices -LRB- PCNA , MIB1 -RRB- .
15274338	1	p53	109,112	PCNA	162,166	p53	PCNA	7157	5111	Gene	Gene	Correlation|nmod|START_ENTITY steroid|dep|Correlation steroid|nsubj|status status|appos|indices indices|appos|END_ENTITY	Correlation with p53 , steroid receptor status , proliferative indices -LRB- PCNA , MIB1 -RRB- and survival .
15772596	0	p53	22,25	PCNA	66,70	p53	PCNA	7157	5111	Gene	Gene	expressions|nmod|START_ENTITY expressions|appos|END_ENTITY	Higher expressions of p53 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in atrophic oral_lichen_planus and patients with areca quid chewing .
15902973	0	p53	12,15	PCNA	99,103	p53	PCNA	22060(Tax:10090)	18538(Tax:10090)	Gene	Gene	protooncogene|compound|START_ENTITY protooncogene|appos|END_ENTITY	Analysis of p53 tumor suppressor gene , H-ras protooncogene and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in squamous_cell_carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen -LRB- 8-MOP -RRB- and UVA radiation -LRB- PUVA therapy -RRB- .
17625704	0	p53	43,46	PCNA	36,40	p53	PCNA	7157	5111	Gene	Gene	expression|compound|START_ENTITY Proliferating_cell_nuclear_antigen|dep|expression Proliferating_cell_nuclear_antigen|appos|END_ENTITY	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- , p53 and MDM2 expression in Hodgkins_disease .
7910135	0	p53	32,35	PCNA	88,92	p53	PCNA	7157	5111	Gene	Gene	oncoprotein|compound|START_ENTITY analysis|nmod|oncoprotein analysis|appos|END_ENTITY	Immunohistochemical analysis of p53 oncoprotein and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the cervix uteri .
7915517	0	p53	51,54	PCNA	34,38	p53	PCNA	7157	5111	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional regulation of the PCNA promoter by p53 .
9187909	0	p53	0,3	PCNA	126,130	p53	PCNA	7157	5111	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|grade grade|appos|END_ENTITY	p53 and c-jun expression in urinary_bladder_transitional_cell_carcinoma : correlation with proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- histological grade and clinical stage .
9694596	0	p53	34,37	PCNA	75,79	p53	PCNA	7157	5111	Gene	Gene	START_ENTITY|appos|proliferating_cell_nuclear_antigen proliferating_cell_nuclear_antigen|appos|END_ENTITY	Immunohistochemical evaluation of p53 , proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- and bcl-2 expression during bacillus Calmette-Guerin -LRB- BCG -RRB- intravesical instillation therapy for superficial bladder_cancers .
9713468	0	p53	91,94	PCNA	68,72	p53	PCNA	7157	5111	Gene	Gene	karyotype|dep|START_ENTITY index|dep|karyotype index|dep|index index|compound|END_ENTITY	Prognostic significance of different biological markers -LRB- DNA index , PCNA index , apoptosis , p53 , karyotype -RRB- in 126 adenocarcinoma_gastric_biopsies .
22914926	0	p53	21,24	PDCD5	0,5	p53	PDCD5	7157	9141	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway .
22914926	0	p53	70,73	PDCD5	0,5	p53	PDCD5	7157	9141	Gene	Gene	pathway|compound|START_ENTITY regulator|nmod|pathway interacts|nmod|regulator interacts|nsubj|END_ENTITY	PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway .
26433055	0	p53	34,37	PDCD5	0,5	p53	PDCD5	7157	9141	Gene	Gene	dynamics|compound|START_ENTITY regulator|nmod|dynamics functions|nmod|regulator functions|nummod|END_ENTITY	PDCD5 functions as a regulator of p53 dynamics in the DNA damage response .
27056106	0	p53	38,41	PDCD5	17,22	p53	PDCD5	7157	9141	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Corrigendum to '' PDCD5 interacts with p53 and functions as a regulator of p53 dynamics in the DNA damage response '' -LSB- J. Theor .
27056106	0	p53	74,77	PDCD5	17,22	p53	PDCD5	7157	9141	Gene	Gene	dynamics|compound|START_ENTITY regulator|nmod|dynamics interacts|nmod|regulator interacts|nsubj|END_ENTITY	Corrigendum to '' PDCD5 interacts with p53 and functions as a regulator of p53 dynamics in the DNA damage response '' -LSB- J. Theor .
26577528	0	p53	19,22	PDL1	0,4	p53	PDL1	22060(Tax:10090)	60533(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|compound|END_ENTITY	PDL1 Regulation by p53 via miR-34 .
10733530	0	p53	40,43	PERP	0,4	p53	PERP	7157	64065	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	PERP , an apoptosis-associated target of p53 , is a novel member of the PMP-22 / gas3 family .
19158346	0	p53	8,11	PERP	0,4	p53	PERP	7157	64065	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	PERP , a p53 proapoptotic target , mediates apoptotic cell death in renal_ischemia .
15363324	0	p53	47,50	PI3K	74,78	p53	PI3K	7157	5293	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	-LSB- Overexpression of HER2/neu downregulates wild p53 protein expression via PI3K and Ras/Raf/MEK / ERK pathways in human breast_cancer cells -RSB- .
15625017	0	p53	28,31	PI3K	62,66	p53	PI3K	7157	5293	Gene	Gene	protein|compound|START_ENTITY Downregulation|nmod|protein Downregulation|dep|activation activation|amod|END_ENTITY	Downregulation of wild-type p53 protein by HER-2 / neu mediated PI3K pathway activation in human breast_cancer cells : its effect on cell proliferation and implication for therapy .
17329971	0	p53	53,56	PI3K	10,14	p53	PI3K	7157	5290	Gene	Gene	inducer|nmod|START_ENTITY signaling|nmod|inducer END_ENTITY|acl|signaling	Activated PI3K signaling as an endogenous inducer of p53 in human cancer .
26311153	0	p53	139,142	PI3K	89,93	p53	PI3K	7157	5293	Gene	Gene	induction|nmod|START_ENTITY downregulation|nmod|induction downregulation|nmod|phosphatidylinositol_3-kinase phosphatidylinositol_3-kinase|appos|END_ENTITY	Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- and protein kinase C -LRB- PKC -RRB- via induction of p53 in hepatocellular_carcinoma -LRB- HepG2 -RRB- cell line .
14695212	0	p53	50,53	PIG3	13,17	p53	PIG3	7157	9540	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors .
11959846	0	p53	0,3	PIK3CA	42,48	p53	PIK3CA	7157	5290	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|inhibiting inhibiting|dobj|END_ENTITY	p53 regulates cell survival by inhibiting PIK3CA in squamous_cell_carcinomas .
18270270	0	p53	22,25	PIK3CA	40,46	p53	PIK3CA	7157	5290	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian_cancer .
15601585	0	p53	18,21	PKCdelta	0,8	p53	PKCdelta	7157	5580	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	PKCdelta requires p53 for suppression of the transformed phenotype in human colon_cancer cells .
10082513	0	p53	105,108	PKR	45,48	p53	PKR	22060(Tax:10090)	19106(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53 .
10348343	0	p53	101,104	PKR	49,52	p53	PKR	7157	5610	Gene	Gene	protein|compound|START_ENTITY associates|nmod|protein associates|compound|END_ENTITY	The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro .
19210572	0	p53	99,102	PKR	0,3	p53	PKR	7157	5610	Gene	Gene	translation|nmod|START_ENTITY regulate|dobj|translation regulate|nsubj|END_ENTITY	PKR , a cognitive_decline biomarker , can regulate translation via two consecutive molecular targets p53 and Redd1 in lymphocytes of AD patients .
19416861	0	p53	7,10	PKR	0,3	p53	PKR	7157	5610	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	PKR , a p53 target gene , plays a crucial role in the tumor-suppressor function of p53 .
19416861	0	p53	81,84	PKR	0,3	p53	PKR	7157	5610	Gene	Gene	function|nmod|START_ENTITY role|nmod|function plays|dobj|role plays|nsubj|END_ENTITY	PKR , a p53 target gene , plays a crucial role in the tumor-suppressor function of p53 .
19631745	0	p53	101,104	PKR	36,39	p53	PKR	7157	5610	Gene	Gene	role|nmod|START_ENTITY Evidence|dep|role Evidence|nmod|links links|nmod|pathways pathways|compound|END_ENTITY	Evidence of molecular links between PKR and mTOR signalling pathways in Abeta neurotoxicity : role of p53 , Redd1 and TSC2 .
19838063	0	p53	50,53	PKR	0,3	p53	PKR	7157	5610	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	PKR is not a universal target of tumor suppressor p53 in response to genotoxic stress .
24766303	0	p53	17,20	PLCE1	0,5	p53	PLCE1	7157	51196	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	PLCE1 suppresses p53 expression in esophageal_cancer cells .
15383668	0	p53	34,37	PP2A	9,13	p53	PP2A	7157	5524	Gene	Gene	signaling|nmod|START_ENTITY ARF|acl|signaling Role|nmod|ARF Role|nmod|END_ENTITY	Role for PP2A in ARF signaling to p53 .
17245430	0	p53	95,98	PP2A	11,15	p53	PP2A	7157	5524	Gene	Gene	dephosphorylation|nmod|START_ENTITY mediates|dobj|dephosphorylation mediates|nsubj|subunit subunit|compound|END_ENTITY	A specific PP2A regulatory subunit , B56gamma , mediates DNA damage-induced dephosphorylation of p53 at Thr55 .
19139122	0	p53	85,88	PP2A	0,4	p53	PP2A	7157	5524	Gene	Gene	phosphorylation|nmod|START_ENTITY ionizing|nmod|phosphorylation regulates|xcomp|ionizing regulates|nsubj|END_ENTITY	PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53 .
20138402	0	p53	21,24	PP2A	5,9	p53	PP2A	7157	5524	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|I I|appos|END_ENTITY	I -LRB- 2 -RRB- -LRB- PP2A -RRB- regulates p53 and Akt correlatively and leads the neurons to abort apoptosis .
20673369	0	p53	52,55	PP2A	80,84	p53	PP2A	7157	5524	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|END_ENTITY	Cdk5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression .
22289577	0	p53	22,25	PP2A	0,4	p53	PP2A	22060(Tax:10090)	19052(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude_mice through PI3K-Akt-MDM2 signaling suppression .
23622513	0	p53	61,64	PP2A	16,20	p53	PP2A	7157	5524	Gene	Gene	glutamine|nmod|START_ENTITY links|xcomp|glutamine links|nsubj|END_ENTITY	The phosphatase PP2A links glutamine to the tumor suppressor p53 .
21623202	0	p53	122,125	PR	118,120	p53	PR	7157	5241	Gene	Gene	Ki-67|dep|START_ENTITY Ki-67|compound|END_ENTITY	Assessing the impact of polysomy-17 on HER2 status and the correlations of HER2 status with prognostic variables -LRB- ER , PR , p53 , Ki-67 -RRB- in epithelial_ovarian_cancer : a tissue microarray study using immunohistochemistry and fluorescent in situ hybridization .
15531928	0	p53	30,33	PRC1	18,22	p53	PRC1	7157	9055	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis .
15531928	0	p53	75,78	PRC1	18,22	p53	PRC1	7157	9055	Gene	Gene	function|nmod|START_ENTITY uncovers|dobj|function uncovers|nsubj|Identification Identification|nmod|END_ENTITY	Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis .
16909106	0	p53	54,57	PRIMA-1	0,7	p53	PRIMA-1	7157	145270	Gene	Gene	accumulation|nmod|START_ENTITY induces|dobj|accumulation induces|nsubj|END_ENTITY	PRIMA-1 -LRB- MET -RRB- induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins .
15186775	0	p53	89,92	PRMT1	33,38	p53	PRMT1	7157	3276	Gene	Gene	functions|nmod|START_ENTITY functions|nmod|END_ENTITY	Ordered cooperative functions of PRMT1 , p300 , and CARM1 in transcriptional activation by p53 .
10797439	0	p53	32,35	PTEN	26,30	p53	PTEN	7157	5728	Gene	Gene	INK4A|dep|START_ENTITY INK4A|compound|END_ENTITY	Investigation of germline PTEN , p53 , p16 -LRB- INK4A -RRB- / p14 -LRB- ARF -RRB- , and CDK4 alterations in familial_glioma .
11545734	0	p53	36,39	PTEN	14,18	p53	PTEN	7157	5728	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of PTEN transcription by p53 .
11729185	0	p53	14,17	PTEN	0,4	p53	PTEN	7157	5728	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy .
12217521	0	p53	16,19	PTEN	4,8	p53	PTEN	7157	5728	Gene	Gene	tumor|compound|START_ENTITY END_ENTITY|appos|tumor	The PTEN , Mdm2 , p53 tumor suppressor-oncoprotein network .
12620407	0	p53	32,35	PTEN	0,4	p53	PTEN	22060(Tax:10090)	19211(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|suppressor suppressor|compound|END_ENTITY	PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and - independent mechanisms .
12839924	0	p53	91,94	PTEN	56,60	p53	PTEN	7157	5728	Gene	Gene	function|nmod|START_ENTITY inhibiting|dobj|function modulates|advcl|inhibiting modulates|dobj|expression expression|nmod|END_ENTITY	Hepatitis_B_Virus X protein modulates the expression of PTEN by inhibiting the function of p53 , a transcriptional activator in liver cells .
12839945	0	p53	63,66	PTEN	0,4	p53	PTEN	7157	5728	Gene	Gene	inhibitors|dep|START_ENTITY END_ENTITY|dep|inhibitors	PTEN and phosphatidylinositol 3 ' - kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis : evidence for an effect on the tumor and endothelial compartment .
14559824	0	p53	72,75	PTEN	0,4	p53	PTEN	7157	5728	Gene	Gene	interacting|nmod|START_ENTITY reverses|advcl|interacting reverses|nsubj|END_ENTITY	PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute_lymphoblastic_leukemia cells .
16061640	0	p53	25,28	PTEN	39,43	p53	PTEN	22060(Tax:10090)	19211(Tax:10090)	Gene	Gene	Loss|nmod|START_ENTITY decreases|nsubj|Loss decreases|dobj|expression expression|compound|END_ENTITY	Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator_protein_1 and nuclear factor kappaB induced by UV radiation .
16424003	0	p53	54,57	PTEN	0,4	p53	PTEN	7157	5728	Gene	Gene	stabilization|nmod|START_ENTITY autoregulates|nmod|stabilization autoregulates|nsubj|END_ENTITY	PTEN autoregulates its expression by stabilization of p53 in a phosphatase-independent manner .
16916644	0	p53	46,49	PTEN	65,69	p53	PTEN	7157	5728	Gene	Gene	maintenance|nmod|START_ENTITY insights|nmod|maintenance acetylation|nsubj|insights acetylation|nmod|END_ENTITY	Mechanistic insights into maintenance of high p53 acetylation by PTEN .
17409411	0	p53	59,62	PTEN	40,44	p53	PTEN	22060(Tax:10090)	19211(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	The regulation of AMPK beta1 , TSC2 , and PTEN expression by p53 : stress , cell and tissue specificity , and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways .
17982625	0	p53	65,68	PTEN	41,45	p53	PTEN	7157	5728	Gene	Gene	overexpression|nmod|START_ENTITY END_ENTITY|appos|overexpression	Down-regulation of tumor suppressor gene PTEN , overexpression of p53 , plus high proliferating_cell_nuclear_antigen index predict poor patient outcome of hepatocellular_carcinoma after resection .
18339852	0	p53	71,74	PTEN	0,4	p53	PTEN	7157	5728	Gene	Gene	mutations|compound|START_ENTITY setting|nmod|mutations properties|nmod|setting has|dobj|properties has|nsubj|END_ENTITY	PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations .
20926450	0	p53	164,167	PTEN	93,97	p53	PTEN	7157	5728	Gene	Gene	associated|nmod|START_ENTITY DNA|acl|associated damage|nmod|DNA oxidative|dobj|damage lead|xcomp|oxidative lead|csubj|occurring occurring|nmod|motifs motifs|nmod|END_ENTITY	Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53 .
22999923	0	p53	18,21	PTEN	87,91	p53	PTEN	7157	5728	Gene	Gene	gene|compound|START_ENTITY mutation|nmod|gene promotes|nsubj|mutation promotes|nmod|pathway pathway|compound|END_ENTITY	R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3b / PTEN pathway .
23613387	0	p53	17,20	PTEN	0,4	p53	PTEN	7157	5728	Gene	Gene	MAPK|dobj|START_ENTITY MAPK|nsubj|END_ENTITY	PTEN , Akt , MAPK , p53 and p95 expression to predict trastuzumab resistance in HER2 positive breast_cancer .
24718924	0	p53	41,44	PTEN	21,25	p53	PTEN	7157	5728	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The tumor suppressor PTEN interacts with p53 in hereditary_cancer -LRB- Review -RRB- .
25888633	0	p53	98,101	PTEN	76,80	p53	PTEN	7157	5728	Gene	Gene	status|compound|START_ENTITY irrespective|nmod|status END_ENTITY|advmod|irrespective	HDACi inhibits_liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN , irrespective of p53 mutational status .
25888633	0	p53	98,101	PTEN	76,80	p53	PTEN	7157	5728	Gene	Gene	status|compound|START_ENTITY irrespective|nmod|status END_ENTITY|advmod|irrespective	HDACi inhibits_liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN , irrespective of p53 mutational status .
10618379	0	p53	86,89	PTGF-beta	0,9	p53	PTGF-beta	7157	9518	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	PTGF-beta , a type beta transforming growth factor -LRB- TGF-beta -RRB- superfamily member , is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway .
11132926	0	p53	112,115	PTHrP	14,19	p53	PTHrP	7157	5744	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|expression expression|amod|END_ENTITY	Activation of PTHrP gene expression in squamous_carcinoma cell lines by mutant isoforms of the tumor suppressor p53 .
24810057	0	p53	31,34	Palmdelphin	0,11	p53	Palmdelphin	7157	54873	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	Palmdelphin , a novel target of p53 with Ser46 phosphorylation , controls cell death in response to DNA damage .
21930938	0	p53	10,13	Parkin	0,6	p53	Parkin	22060(Tax:10090)	50873(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Parkin , a p53 target gene , mediates the role of p53 in glucose metabolism and the Warburg effect .
24051492	0	p53	0,3	Period2	14,21	p53	Period2	22060(Tax:10090)	18627(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	p53 regulates Period2 expression and the circadian clock .
23917221	0	p53	33,36	Periostin	0,9	p53	Periostin	7157	10631	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal_tumor microenvironment .
16887883	0	p53	59,62	Peroxisome_proliferator-activated_receptor-gamma	0,48	p53	Peroxisome proliferator-activated receptor-gamma	7157	5468	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast_cancer cells .
10973264	0	p53	59,62	Pidd	0,4	p53	Pidd	22059(Tax:10090)	57913(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Pidd , a new death-domain-containing protein , is induced by p53 and promotes apoptosis .
12388558	0	p53	34,37	Pin1	8,12	p53	Pin1	7157	5300	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability END_ENTITY|nmod|regulation	Role of Pin1 in the regulation of p53 stability and p21 transactivation , and cell cycle checkpoints in response to DNA damage .
12397361	0	p53	44,47	Pin1	21,25	p53	Pin1	7157	5300	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response .
12397362	0	p53	57,60	Pin1	21,25	p53	Pin1	7157	5300	Gene	Gene	functions|compound|START_ENTITY control|dobj|functions mechanism|acl|control reveals|dobj|mechanism reveals|nsubj|END_ENTITY	The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults .
15893113	0	p53	0,3	Pin1	28,32	p53	Pin1	7157	5300	Gene	Gene	Protein|compound|START_ENTITY activated|nsubj|Protein activated|nmod|END_ENTITY	p53 Protein is activated by Pin1 : and also by Cu-SOD prion-like enzyme .
15964795	0	p53	27,30	Pin1	56,60	p53	Pin1	7157	5300	Gene	Gene	proline|nmod|START_ENTITY Mutations|nmod|proline impair|nsubj|Mutations impair|nmod|END_ENTITY	Mutations in proline 82 of p53 impair its activation by Pin1 and Chk2 in response to DNA damage .
17906639	0	p53	39,42	Pin1	21,25	p53	Pin1	7157	5300	Gene	Gene	acetylation|compound|START_ENTITY orchestrates|dobj|acetylation orchestrates|nsubj|END_ENTITY	The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP .
21926448	0	p53	54,57	Pin1	32,36	p53	Pin1	7157	5300	Gene	Gene	unleashes|dobj|START_ENTITY unleashes|nsubj|END_ENTITY	Wiring the oncogenic circuitry : Pin1 unleashes mutant p53 .
22017796	0	p53	47,50	Pin1	26,30	p53	Pin1	7157	5300	Gene	Gene	empowers|dobj|START_ENTITY empowers|nsubj|END_ENTITY	The amplifier effect : how Pin1 empowers mutant p53 .
22935610	0	p53	71,74	Pin1	21,25	p53	Pin1	7157	5300	Gene	Gene	program|nmod|START_ENTITY activates|dobj|program activates|nsubj|END_ENTITY	The prolyl-isomerase Pin1 activates the mitochondrial death program of p53 .
25451271	0	p53	0,3	Pin1	25,29	p53	Pin1	7157	5300	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	p53 negatively regulates Pin1 expression under ER stress .
17380130	0	p53	78,81	Pit-1	72,77	p53	Pit-1	22060(Tax:10090)	18736(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|/ /|amod|END_ENTITY	The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1 / p53 pathway , preventing tumor growth .
17762884	0	p53	30,33	Pitx1	37,42	p53	Pitx1	7157	5307	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of p53 by Pitx1 .
22303479	0	p53	18,21	Piwil2	0,6	p53	Piwil2	7157	55124	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	Piwil2 suppresses p53 by inducing phosphorylation of signal_transducer_and_activator_of_transcription_3 in tumor cells .
16862142	0	p53	69,72	Plasminogen_activator_inhibitor-1	0,33	p53	Plasminogen activator inhibitor-1	7157	5054	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Plasminogen_activator_inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence .
15024021	0	p53	35,38	Polo-like_kinase_1	0,18	p53	Polo-like kinase 1	7157	5347	Gene	Gene	function|compound|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Polo-like_kinase_1 -LRB- Plk1 -RRB- inhibits p53 function by physical interaction and phosphorylation .
16753148	0	p53	94,97	Polo-like_kinase_1	0,18	p53	Polo-like kinase 1	7157	5347	Gene	Gene	dephosphorylation|nmod|START_ENTITY mitotic_arrest|nmod|dephosphorylation regulates|xcomp|mitotic_arrest regulates|nsubj|END_ENTITY	Polo-like_kinase_1 regulates mitotic_arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation .
20577264	0	p53	90,93	Polo-like_kinase_1	0,18	p53	Polo-like kinase 1	7157	5347	Gene	Gene	inactivation|compound|START_ENTITY essential|nmod|inactivation essential|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Polo-like_kinase_1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery .
22184120	0	p53	68,71	Polo-like_kinase_1	88,106	p53	Polo-like kinase 1	7157	5347	Gene	Gene	protein|compound|START_ENTITY regulated|nmod|protein regulated|nmod|END_ENTITY	Centrosomal_protein_55 -LRB- Cep55 -RRB- stability is negatively regulated by p53 protein through Polo-like_kinase_1 -LRB- Plk1 -RRB- .
22262171	0	p53	2,5	Polo-like_kinase_1	50,68	p53	Polo-like kinase 1	7157	5347	Gene	Gene	relevant|nsubj|START_ENTITY relevant|nmod|response response|nmod|inhibitors inhibitors|compound|END_ENTITY	p53 is not directly relevant to the response of Polo-like_kinase_1 inhibitors .
14500729	0	p53	51,54	Prohibitin	0,10	p53	Prohibitin	7157	5245	Gene	Gene	activity|nmod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling .
17625704	0	p53	43,46	Proliferating_cell_nuclear_antigen	0,34	p53	Proliferating cell nuclear antigen	7157	5111	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- , p53 and MDM2 expression in Hodgkins_disease .
16118209	0	p53	115,118	Protein_kinase_C_delta	0,22	p53	Protein kinase C delta	7157	5580	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	Protein_kinase_C_delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms .
15380514	0	p53	103,106	Ptc1	94,98	p53	Ptc1	22060(Tax:10090)	19206(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 -LRB- + / - -RRB- p53 -LRB- - / - -RRB- mice .
19880522	0	p53	19,22	Pyk2	0,4	p53	Pyk2	22060(Tax:10090)	19229(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival .
11118038	0	p53	76,79	RB18A	0,5	p53	RB18A	7157	5469	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	RB18A , whose gene is localized on chromosome 17q12-q21 .1 , regulates in vivo p53 transactivating activity .
15848166	0	p53	36,39	RB18A	0,5	p53	RB18A	7157	5469	Gene	Gene	protein|compound|START_ENTITY expression|nmod|protein enhances|dobj|expression enhances|nsubj|END_ENTITY	RB18A enhances expression of mutant p53 protein in human cells .
9444950	0	p53	116,119	RB18A	18,23	p53	RB18A	7157	5469	Gene	Gene	properties|nmod|START_ENTITY shares|dobj|properties protein|acl:relcl|shares Identification|appos|protein Identification|nmod|END_ENTITY	Identification of RB18A , a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53 .
9444950	0	p53	39,42	RB18A	18,23	p53	RB18A	7157	5469	Gene	Gene	protein|compound|START_ENTITY Identification|appos|protein Identification|nmod|END_ENTITY	Identification of RB18A , a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53 .
25556649	0	p53	17,20	RECQL4	0,6	p53	RECQL4	7157	9401	Gene	Gene	Regulates|xcomp|START_ENTITY Regulates|nsubj|END_ENTITY	RECQL4 Regulates p53 Function In Vivo During Skeletogenesis .
25556649	0	p53	17,20	RECQL4	0,6	p53	RECQL4	7157	9401	Gene	Gene	Regulates|xcomp|START_ENTITY Regulates|nsubj|END_ENTITY	RECQL4 Regulates p53 Function In Vivo During Skeletogenesis .
21084564	0	p53	19,22	REGgamma	0,8	p53	REGgamma	7157	10197	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	REGgamma modulates p53 activity by regulating its cellular localization .
21531726	0	p53	0,3	RGS13	25,30	p53	RGS13	22060(Tax:10090)	246709(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	p53 negatively regulates RGS13 protein expression in immune cells .
15558054	0	p53	29,32	RITA	15,19	p53	RITA	7157	55422	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Small molecule RITA binds to p53 , blocks p53-HDM-2 interaction and activates p53 function in tumors .
20395210	0	p53	10,13	RITA	41,45	p53	RITA	7157	84934	Gene	Gene	Rescue|nmod|START_ENTITY function|nsubj|Rescue function|nmod|END_ENTITY	Rescue of p53 function by small-molecule RITA in cervical_carcinoma by blocking E6-mediated degradation .
20436301	0	p53	52,55	RITA	74,78	p53	RITA	7157	55422	Gene	Gene	function|nmod|START_ENTITY Rescue|nmod|function Rescue|nmod|END_ENTITY	Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA .
22276160	0	p53	10,13	RITA	47,51	p53	RITA	7157	84934	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Targeting p53 via JNK pathway : a novel role of RITA for apoptotic signaling in multiple_myeloma .
22476102	0	p53	124,127	RITA	72,76	p53	RITA	7157	55422	Gene	Gene	agents|compound|START_ENTITY retain|nmod|agents retain|nsubj|cells cells|nmod|resistance resistance|nmod|END_ENTITY	Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents .
22476102	0	p53	95,98	RITA	72,76	p53	RITA	7157	55422	Gene	Gene	retain|dobj|START_ENTITY retain|nsubj|cells cells|nmod|resistance resistance|nmod|END_ENTITY	Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents .
23864164	0	p53	39,42	RITA	61,65	p53	RITA	7157	55422	Gene	Gene	Dual|nmod|START_ENTITY Dual|nmod|END_ENTITY	Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro .
24308154	10	p53	1238,1241	RITA	1206,1210	p53	RITA	7157	84934	Gene	Gene	levels|compound|START_ENTITY upregulated|dobj|levels upregulated|nsubj|overexpression overexpression|compound|END_ENTITY	RITA overexpression upregulated p53 and reduced cyclin E levels , whereas silencing of RITA had the opposite effect on p53 and cyclin E expression .
24345738	0	p53	29,32	RITA	41,45	p53	RITA	7157	84934	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural_mesothelioma .
24927749	0	p53	122,125	RITA	0,4	p53	RITA	7157	84934	Gene	Gene	pathway|compound|START_ENTITY efficient|nmod|pathway efficient|nsubj|END_ENTITY	RITA -LRB- Reactivating p53_and_Inducing_Tumor_Apoptosis -RRB- is efficient against TP53abnormal myeloma cells independently of the p53 pathway .
25010984	0	p53	67,70	RITA	0,4	p53	RITA	7157	55422	Gene	Gene	function|compound|START_ENTITY cells|nmod|function induce|nmod|cells induce|nsubj|END_ENTITY	RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38 .
23814485	0	p53	6,9	RKIP	23,27	p53	RKIP	7157	5037	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new p53 target gene , RKIP , is essential for DNA damage-induced cellular senescence and suppression of ERK activation .
21764855	0	p53	44,47	RNPC1	35,40	p53	RNPC1	7157	55544	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	Translational repression of p53 by RNPC1 , a p53 target overexpressed in lymphomas .
26687066	0	p53	35,38	RPL26	69,74	p53	RPL26	7157	6154	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p .
19558368	0	p53	45,48	RREB-1	31,37	p53	RREB-1	7157	6239	Gene	Gene	promoter|compound|START_ENTITY END_ENTITY|nmod|promoter	DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter .
20353948	0	p53	72,75	RUNX3	0,5	p53	RUNX3	7157	864	Gene	Gene	phosphorylation|nmod|START_ENTITY modulates|dobj|phosphorylation modulates|nsubj|END_ENTITY	RUNX3 modulates DNA damage-mediated phosphorylation of tumor suppressor p53 at Ser-15 and acts as a co-activator for p53 .
19098711	0	p53	16,19	RYBP	0,4	p53	RYBP	7157	23429	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	RYBP stabilizes p53 by modulating MDM2 .
11258707	0	p53	32,35	Raf	61,64	p53	Raf	22060(Tax:10090)	387609(Tax:10090)	Gene	Gene	arrest|compound|START_ENTITY induction|nmod|arrest induction|nmod|END_ENTITY	p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes .
7784054	0	p53	19,22	Raf	0,3	p53	Raf	22060(Tax:10090)	387609(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Raf phosphorylates p53 in vitro and potentiates p53-dependent transcriptional transactivation in vivo .
9137531	0	p53	41,44	Raf-1	24,29	p53	Raf-1	7157	5894	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Depletion of p185erbB2 , Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity .
25728512	0	p53	32,35	Rap2a	0,5	p53	Rap2a	7157	5911	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion .
23535297	0	p53	15,18	Rap2b	0,5	p53	Rap2b	7157	5912	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	Rap2b , a novel p53 target , regulates p53-mediated pro-survival function .
17380130	0	p53	78,81	Ret	24,27	p53	Ret	22060(Tax:10090)	19713(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY induces|nmod|pathway induces|nsubj|END_ENTITY	The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1 / p53 pathway , preventing tumor growth .
25144937	0	p53	59,62	Ribosomal_protein_S27-like	0,26	p53	Ribosomal protein S27-like	22059(Tax:10090)	67941(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Ribosomal_protein_S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis .
23148227	0	p53	72,75	Runt-related_transcription_factor_1	0,35	p53	Runt-related transcription factor 1	7157	861	Gene	Gene	protein|compound|START_ENTITY stimulates|dobj|protein stimulates|nsubj|END_ENTITY	Runt-related_transcription_factor_1 -LRB- RUNX1 -RRB- stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation .
10094469	0	p53	69,72	S100A2	40,46	p53	S100A2	7157	6273	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional activation of the human S100A2 promoter by wild-type p53 .
15941720	0	p53	50,53	S100A2	28,34	p53	S100A2	7157	6273	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity .
16367903	0	p53	120,123	S100A2	27,33	p53	S100A2	7157	6273	Gene	Gene	relationship|nmod|START_ENTITY significance|appos|relationship expression|dep|significance expression|nmod|END_ENTITY	Differential expression of S100A2 and S100A4 in lung_adenocarcinomas : clinicopathological significance , relationship to p53 and identification of their target genes .
16449968	0	p53	50,53	S100A2	0,6	p53	S100A2	22060(Tax:10090)	628324(Tax:10090)	Gene	Gene	homologues|compound|START_ENTITY target|nmod|homologues target|nsubj|gene gene|compound|END_ENTITY	S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation .
24556685	0	p53	96,99	S100A2	0,6	p53	S100A2	7157	6273	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability roles|nmod|regulation gene|nmod|roles gene|nsubj|END_ENTITY	S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability .
23352991	0	p53	102,105	S100A4	31,37	p53	S100A4	22060(Tax:10090)	20198(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY cardiac_fibrosis|nmod|modulation cardiac_fibrosis|nsubj|protein protein|appos|mediates mediates|nummod|END_ENTITY	Metastasis-associated protein , S100A4 mediates cardiac_fibrosis potentially through the modulation of p53 in cardiac fibroblasts .
23752197	0	p53	22,25	S100A4	0,6	p53	S100A4	7157	6275	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	S100A4 interacts with p53 in the nucleus and promotes p53 degradation .
26497012	0	p53	29,32	S100A4	0,6	p53	S100A4	7157	6275	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	S100A4 interacts with mutant p53 and affects gastric_cancer MKN1 cell autophagy and differentiation .
18765292	0	p53	13,16	S100A6	0,6	p53	S100A6	7157	6277	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	S100A6 binds p53 and affects its activity .
23796514	0	p53	60,63	S100A6	0,6	p53	S100A6	7157	6277	Gene	Gene	binding|nmod|START_ENTITY acetylation|amod|binding p300|nmod|acetylation domain|nmod|p300 competes|nmod|domain competes|nsubj|END_ENTITY	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
23796514	0	p53	79,82	S100A6	0,6	p53	S100A6	7157	6277	Gene	Gene	acetylation|compound|START_ENTITY p300|nmod|acetylation domain|nmod|p300 competes|nmod|domain competes|nsubj|END_ENTITY	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
19534726	0	p53	8,11	S100A9	25,31	p53	S100A9	7157	6280	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel p53 target gene , S100A9 , induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway .
20587415	0	p53	49,52	S100B	28,33	p53	S100B	7157	6285	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant_melanoma .
26967060	0	p53	54,57	S100P	18,23	p53	S100P	7157	6286	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|protein protein|compound|END_ENTITY	Cancer-associated S100P protein binds and inactivates p53 , permits therapy-induced senescence and supports chemoresistance .
15378026	0	p53	10,13	SAP	24,27	p53	SAP	7157	4068	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|expression expression|compound|END_ENTITY	Wild-type p53 activates SAP expression in lymphoid cells .
23870121	0	p53	107,110	SET1	0,4	p53	SET1	7157	9739	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	SET1 and p300 act synergistically , through coupled histone modifications , in transcriptional activation by p53 .
18260647	0	p53	118,121	SET7/9	170,176	p53	SET7/9	7157	80854	Gene	Gene	methylation|compound|START_ENTITY methylation|nmod|END_ENTITY	Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases : transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9 .
24565839	0	p53	0,3	SETDB1	19,25	p53	SETDB1	7157	9869	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	p53 down-regulates SETDB1 gene expression during paclitaxel induced-cell death .
25723258	0	p53	66,69	SHIP1	21,26	p53	SHIP1	7157	3635	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies .
19749791	0	p53	34,37	SHP-1	14,19	p53	SHP-1	7157	8431	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast_cancer cell proliferation .
11672523	0	p53	43,46	SIRT1	6,11	p53	SIRT1	7157	23411	Gene	Gene	deacetylase|nmod|START_ENTITY deacetylase|nsubj|functions functions|appos|END_ENTITY	hSIR2 -LRB- SIRT1 -RRB- functions as an NAD-dependent p53 deacetylase .
16354677	0	p53	49,52	SIRT1	14,19	p53	SIRT1	7157	23411	Gene	Gene	acetylation|compound|START_ENTITY increases|dobj|acetylation increases|nsubj|Inhibition Inhibition|nmod|activity activity|compound|END_ENTITY	Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage .
16785031	0	p53	104,107	SIRT1	32,37	p53	SIRT1	7157	23411	Gene	Gene	deacetylation|compound|START_ENTITY apoptosis|nmod|deacetylation oxidative|dobj|apoptosis oxidative|nsubj|attenuates attenuates|appos|END_ENTITY	Silent_information_regulator_2 -LRB- SIRT1 -RRB- attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation .
17595514	0	p53	67,70	SIRT1	103,108	p53	SIRT1	7157	23411	Gene	Gene	START_ENTITY|nmod|decrease decrease|nmod|function function|nmod|END_ENTITY	H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD + depletion .
17964266	0	p53	79,82	SIRT1	20,25	p53	SIRT1	7157	23411	Gene	Gene	activity|compound|START_ENTITY suppression|nmod|activity cooperates|nmod|suppression cooperates|nsubj|regulator regulator|nmod|END_ENTITY	Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity .
17964266	0	p53	79,82	SIRT1	42,47	p53	SIRT1	7157	23411	Gene	Gene	activity|compound|START_ENTITY suppression|nmod|activity suppression|compound|END_ENTITY	Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity .
18371449	0	p53	92,95	SIRT1	0,5	p53	SIRT1	22060(Tax:10090)	93759(Tax:10090)	Gene	Gene	localization|compound|START_ENTITY regulates|nmod|localization regulates|nsubj|END_ENTITY	SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization .
18681908	0	p53	84,87	SIRT1	0,5	p53	SIRT1	7157	23411	Gene	Gene	modulation|nmod|START_ENTITY death|nmod|modulation protection|nmod|death confers|dobj|protection confers|nsubj|END_ENTITY	SIRT1 confers protection against UVB - and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes .
20931131	0	p53	61,64	SIRT1	52,57	p53	SIRT1	7157	23411	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|activity activity|nmod|END_ENTITY	Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen technology .
20975832	0	p53	74,77	SIRT1	0,5	p53	SIRT1	7157	23411	Gene	Gene	loop|nmod|START_ENTITY undergoes|nmod|loop undergoes|nsubj|END_ENTITY	SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53 .
21149449	0	p53	15,18	SIRT1	90,95	p53	SIRT1	7157	23411	Gene	Gene	activity|compound|START_ENTITY Suppression|nmod|activity deacetylase|nsubj|Suppression deacetylase|dobj|END_ENTITY	Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1 .
21245319	0	p53	35,38	SIRT1	79,84	p53	SIRT1	7157	23411	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|advcl|interacting interacting|nmod|Sirtuin_1 Sirtuin_1|appos|END_ENTITY	Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin_1 -LRB- SIRT1 -RRB- .
21593185	0	p53	100,103	SIRT1	0,5	p53	SIRT1	22060(Tax:10090)	93759(Tax:10090)	Gene	Gene	deacetylation|nmod|START_ENTITY cisplatin-induced|nmod|deacetylation cisplatin-induced|nsubj|activation activation|nummod|END_ENTITY	SIRT1 activation by resveratrol ameliorates cisplatin-induced renal_injury through deacetylation of p53 .
21968188	0	p53	0,3	SIRT1	21,26	p53	SIRT1	7157	23411	Gene	Gene	deacetylation|compound|START_ENTITY deacetylation|nmod|END_ENTITY	p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence .
22124156	0	p53	95,98	SIRT1	24,29	p53	SIRT1	7157	23411	Gene	Gene	regulating|dobj|START_ENTITY opposes|advcl|regulating opposes|nsubj|variant variant|compound|END_ENTITY	A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes .
22124156	0	p53	95,98	SIRT1	58,63	p53	SIRT1	7157	23411	Gene	Gene	regulating|dobj|START_ENTITY opposes|advcl|regulating opposes|dobj|END_ENTITY	A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes .
22340598	0	p53	14,17	SIRT1	21,26	p53	SIRT1	7157	23411	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Activation of p53 by SIRT1 inhibition enhances elimination of CML_leukemia stem cells in combination with imatinib .
22728651	0	p53	14,17	SIRT1	70,75	p53	SIRT1	7157	23411	Gene	Gene	acetylation|compound|START_ENTITY acetylation|nmod|END_ENTITY	AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver_cancer cells .
22732402	0	p53	72,75	SIRT1	14,19	p53	SIRT1	7157	23411	Gene	Gene	pathway|compound|START_ENTITY activation|nmod|pathway results|nmod|activation results|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway .
23661372	0	p53	94,97	SIRT1	18,23	p53	SIRT1	22060(Tax:10090)	93759(Tax:10090)	Gene	Gene	regulation|compound|START_ENTITY corneal_epithelial_wound_healing|nmod|regulation promotes|dobj|corneal_epithelial_wound_healing promotes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of SIRT1 promotes high glucose-attenuated corneal_epithelial_wound_healing via p53 regulation of the IGFBP3/IGF -1 R/AKT pathway .
23846322	0	p53	17,20	SIRT1	26,31	p53	SIRT1	7157	23411	Gene	Gene	Targeting|dobj|START_ENTITY Targeting|nmod|YK-3-237 YK-3-237|compound|END_ENTITY	Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative_breast_cancer cells .
24020002	0	p53	20,23	SIRT1	0,5	p53	SIRT1	7157	23411	Gene	Gene	Deacetylation|compound|START_ENTITY Regulator|nmod|Deacetylation END_ENTITY|dep|Regulator	SIRT1 : Regulator of p53 Deacetylation .
24298365	0	p53	15,18	SIRT1	0,5	p53	SIRT1	22060(Tax:10090)	93759(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Inhibits Inhibits|compound|END_ENTITY	SIRT1 Inhibits p53 but not NF-kB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies .
24855208	0	p53	40,43	SIRT1	0,5	p53	SIRT1	7157	23411	Gene	Gene	activation|compound|START_ENTITY prevents|dobj|activation prevents|nsubj|END_ENTITY	SIRT1 prevents genotoxic stress-induced p53 activation in acute_myeloid_leukemia .
24959379	0	p53	64,67	SIRT1	0,5	p53	SIRT1	7157	23411	Gene	Gene	acetylation|compound|START_ENTITY regulates|dobj|acetylation regulates|nsubj|phosphorylation phosphorylation|nummod|END_ENTITY	SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation .
25389371	0	p53	122,125	SIRT1	74,79	p53	SIRT1	7157	23411	Gene	Gene	acetylation|nmod|START_ENTITY increase|dobj|acetylation induce|advcl|increase induce|dobj|S-nitrosylation S-nitrosylation|nmod|END_ENTITY	Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65 .
25950477	0	p53	88,91	SIRT1	40,45	p53	SIRT1	7157	23411	Gene	Gene	acetylation|compound|START_ENTITY regulate|dobj|acetylation form|xcomp|regulate form|nsubj|Acetylation Acetylation|nmod|HDAC1 HDAC1|nmod|END_ENTITY	Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress .
26515559	0	p53	31,34	SIRT1	66,71	p53	SIRT1	7157	23411	Gene	Gene	acetylation|compound|START_ENTITY enhanced|dobj|acetylation enhanced|nmod|dissociation dissociation|nmod|END_ENTITY	HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis .
26515559	0	p53	77,80	SIRT1	66,71	p53	SIRT1	7157	23411	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nmod|dissociation dissociation|nmod|END_ENTITY	HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis .
25009184	0	p53	17,20	SIRT6	37,42	p53	SIRT6	22060(Tax:10090)	50721(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion .
15105421	0	p53	88,91	SIVA	22,26	p53	SIVA	7157	10572	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 .
25813352	0	p53	4,7	SIVA	20,24	p53	SIVA	7157	10572	Gene	Gene	START_ENTITY|dep|Development Development|compound|END_ENTITY	The p53 Target Gene SIVA Enables Non-Small_Cell_Lung_Cancer Development .
24681808	0	p53	61,64	SLC25A1	0,7	p53	SLC25A1	7157	6576	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SLC25A1 , or CIC , is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker .
24858040	0	p53	81,84	SLC2A9	26,32	p53	SLC2A9	7157	56606	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	The uric_acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense .
15701641	0	p53	48,51	SMAR1	17,22	p53	SMAR1	22060(Tax:10090)	53325(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Tumor suppressor SMAR1 activates and stabilizes p53 through its arginine-serine-rich motif .
21701263	0	p53	44,47	SMG1	29,33	p53	SMG1	7157	23049	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA .
24449765	0	p53	14,17	SMRT	46,50	p53	SMRT	7157	9612	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Activation of p53 transcriptional activity by SMRT : a histone_deacetylase_3-independent function of a transcriptional corepressor .
25435374	0	p53	113,116	SOX30	0,5	p53	SOX30	7157	11063	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	SOX30 , a novel epigenetic silenced tumor suppressor , promotes tumor cell apoptosis by transcriptional activating p53 in lung_cancer .
21300779	0	p53	81,84	SPATA18	0,7	p53	SPATA18	22060(Tax:10090)	73472(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SPATA18 , a spermatogenesis-associated gene , is a novel transcriptional target of p53 and p63 .
23478443	0	p53	45,48	SRSF1	28,33	p53	SRSF1	7157	6426	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence .
14602726	0	p53	22,25	STAT-1	0,6	p53	STAT-1	7157	6772	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis .
26617467	0	p53	79,82	STAT1	0,5	p53	STAT1	7157	6772	Gene	Gene	induction|nmod|START_ENTITY inhibits|nmod|induction inhibits|nsubj|END_ENTITY	STAT1 inhibits human hepatocellular_carcinoma cell growth through induction of p53 and Fbxw7 .
18941194	0	p53	148,151	STAT3	121,126	p53	STAT3	7157	6774	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	IL-24 induces apoptosis of chronic_lymphocytic_leukemia B cells engaged into the cell cycle through dephosphorylation of STAT3 and stabilization of p53 expression .
10562558	0	p53	14,17	SUMO-1	63,69	p53	SUMO-1	7157	7341	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1 .
21900752	0	p53	39,42	SUMO-2	14,20	p53	SUMO-2	22060(Tax:10090)	170930(Tax:10090)	Gene	Gene	modification|nmod|START_ENTITY END_ENTITY|dep|modification	MDM2 promotes SUMO-2 / 3 modification of p53 to modulate transcriptional activity .
11495913	0	p53	40,43	Ser15	117,122	p53	Ser15	7157	3190208(Tax:176280)	Gene	Gene	phosphorylation|compound|START_ENTITY induces|nmod|phosphorylation induces|nmod|p38MAPK p38MAPK|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Osmotic_shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20 .
11562441	0	p53	110,113	Ser15	136,141	p53	Ser15	7157	3190208(Tax:176280)	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|acl:relcl|unmodified unmodified|nmod|END_ENTITY	The cyclin-dependent kinase inhibitor roscovitine inhibits RNA synthesis and triggers nuclear accumulation of p53 that is unmodified at Ser15 and Lys382 .
12853888	0	p53	40,43	Ser15	15,20	p53	Ser15	7157	3190208(Tax:176280)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	NB1011 induces Ser15 phosphorylation of p53 and activates the G2/M checkpoint .
15381086	0	p53	37,40	Ser15	52,57	p53	Ser15	7157	3190208(Tax:176280)	Gene	Gene	protein|compound|START_ENTITY substituted|dobj|protein substituted|nmod|END_ENTITY	Stabilization of alanine substituted p53 protein at Ser15 , Thr18 , and Ser20 in response to ionizing radiation .
17932951	0	p53	159,162	Ser15	163,168	p53	Ser15	7157	3190208(Tax:176280)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|compound|END_ENTITY	Anti-diol_epoxide of benzo -LSB- a -RSB- pyrene induces transient Mdm2 and p53 Ser15 phosphorylation , while anti-diol_epoxide of dibenzo -LSB- a , l -RSB- pyrene induces a nontransient p53 Ser15 phosphorylation .
22288499	0	p53	0,3	Ser15	4,9	p53	Ser15	7157	3190208(Tax:176280)	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|amod|END_ENTITY	p53 Ser15 phosphorylation disrupts the p53-RPA70 complex and induces RPA70-mediated DNA repair in hypoxia .
22532570	0	p53	52,55	Ser15	73,78	p53	Ser15	22060(Tax:10090)	3190208(Tax:176280)	Gene	Gene	function|compound|START_ENTITY activates|dobj|function activates|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Murine_protein_serine-threonine_kinase_38 activates p53 function through Ser15 phosphorylation .
23759592	0	p53	0,3	Ser15	4,9	p53	Ser15	7157	3190208(Tax:176280)	Gene	Gene	phosphorylation|nummod|START_ENTITY phosphorylation|amod|END_ENTITY	p53 Ser15 phosphorylation and histone modifications contribute to IR-induced miR-34a transcription in mammary epithelial cells .
18280244	0	p53	38,41	Set7/9	22,28	p53	Set7/9	22060(Tax:10090)	73251(Tax:10090)	Gene	Gene	acetylation|compound|START_ENTITY mediates|dobj|acetylation mediates|nsubj|Methylation Methylation|nmod|p53 p53|nmod|END_ENTITY	Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo .
21245319	0	p53	35,38	Set7/9	18,24	p53	Set7/9	7157	80854	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin_1 -LRB- SIRT1 -RRB- .
15380514	0	p53	103,106	Shh	19,22	p53	Shh	22060(Tax:10090)	20423(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY medulloblastoma|nmod|mice eliminates|dobj|medulloblastoma eliminates|nsubj|Suppression Suppression|nmod|pathway pathway|compound|END_ENTITY	Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 -LRB- + / - -RRB- p53 -LRB- - / - -RRB- mice .
21528083	0	p53	33,36	Shp2	9,13	p53	Shp2	7157	5781	Gene	Gene	ADCY-2|appos|START_ENTITY ADCY-2|appos|END_ENTITY	SPARCL1 , Shp2 , MSH2 , E-cadherin , p53 , ADCY-2 and MAPK are prognosis-related in colorectal_cancer .
14985507	0	p53	46,49	Siah-1b	0,7	p53	Siah-1b	7157	20438(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
14985507	0	p53	84,87	Siah-1b	0,7	p53	Siah-1b	7157	20438(Tax:10090)	Gene	Gene	functional|dep|START_ENTITY element|amod|functional identification|nmod|element target|dep|identification target|nsubj|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
19377286	0	p53	8,11	Sirt1	49,54	p53	Sirt1	7157	23411	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|nmod|inhibition inhibition|amod|END_ENTITY	Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate_cancer cells .
22542455	0	p53	18,21	Sirt1	69,74	p53	Sirt1	22060(Tax:10090)	93759(Tax:10090)	Gene	Gene	activation|nummod|START_ENTITY antagonizes|dobj|activation antagonizes|advcl|deubiquitinating deubiquitinating|dobj|END_ENTITY	USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development .
26902357	0	p53	16,19	Sirt1	0,5	p53	Sirt1	301300(Tax:10116)	309757(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Regulates Regulates|compound|END_ENTITY	Sirt1 Regulates p53 Stability and Expression of Its Target S100B during Long-Term Potentiation in Rat Hippocampus .
21386086	0	p53	22,25	Sirtuin_1	12,21	p53	Sirtuin 1	22060(Tax:10090)	93759(Tax:10090)	Gene	Gene	essential|nsubj|START_ENTITY END_ENTITY|parataxis|essential	The central Sirtuin_1 / p53 pathway is essential for the orexigenic action of ghrelin .
17464332	0	p53	31,34	Siva	0,4	p53	Siva	7157	10572	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Siva is an apoptosis-selective p53 target gene important for neuronal cell death .
23462994	0	p53	15,18	Siva1	0,5	p53	Siva1	7157	10572	Gene	Gene	function|compound|START_ENTITY inhibits|dobj|function inhibits|nsubj|END_ENTITY	Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase .
24008423	0	p53	66,69	Slug	0,4	p53	Slug	22060(Tax:10090)	20583(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Slug expression in mouse skin and skin_tumors is not regulated by p53 .
22805162	0	p53	15,18	SnoN	0,4	p53	SnoN	22060(Tax:10090)	20482(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	SnoN activates p53 directly to regulate aging and tumorigenesis .
21042410	0	p53	34,37	Sonic_hedgehog	18,32	p53	Sonic hedgehog	30590(Tax:7955)	30269(Tax:7955)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|absence absence|nmod|END_ENTITY	In the absence of Sonic_hedgehog , p53 induces apoptosis and inhibits retinal cell proliferation , cell-cycle exit and differentiation in zebrafish .
21242964	0	p53	34,37	Sp1	46,49	p53	Sp1	7157	6667	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors .
9449526	0	p53	0,3	Sp1	14,17	p53	Sp1	7157	6667	Gene	Gene	DNA|compound|START_ENTITY DNA|compound|END_ENTITY	p53 represses Sp1 DNA binding and HIV-LTR directed transcription .
24967584	0	p53	121,124	Spns1	139,144	p53	Spns1	2768677(Tax:7227)	799873(Tax:7955)	Gene	Gene	START_ENTITY|nmod|deficiency deficiency|amod|END_ENTITY	Aberrant autolysosomal regulation is linked to the induction of embryonic senescence : differential roles of Beclin_1 and p53 in vertebrate Spns1 deficiency .
15064739	0	p53	18,21	Staf50	0,6	p53	Staf50	7157	10346	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells .
12082540	0	p53	0,3	Stat3	14,19	p53	Stat3	7157	6774	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate_cancer cells expressing constitutively active Stat3 .
19574718	0	p53	16,19	Stat3	3,8	p53	Stat3	7157	6774	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Is Stat3 and/or p53 mRNA expression a prognostic marker for renal_cell_carcinoma ?
10551785	0	p53	126,129	Steroid_receptor_coactivator-1	0,30	p53	Steroid receptor coactivator-1	7157	8648	Gene	Gene	regulate|nmod|START_ENTITY regulate|nsubj|END_ENTITY	Steroid_receptor_coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53 .
17916908	0	p53	23,26	Survivin	0,8	p53	Survivin	7157	11799(Tax:10090)	Gene	Gene	repression|nmod|START_ENTITY repression|compound|END_ENTITY	Survivin repression by p53 , Rb and E2F2 in normal human melanocytes .
10618714	0	p53	0,3	TAP1	12,16	p53	TAP1	7157	6890	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	p53 induces TAP1 and enhances the transport of MHC class I peptides .
8754830	0	p53	31,34	TATA-binding_protein	40,60	p53	TATA-binding protein	2768677(Tax:7227)	37476(Tax:7227)	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Functional interaction between p53 , the TATA-binding_protein -LRB- TBP -RRB- , andTBP-associated factors in vivo .
18549481	0	p53	63,66	TATA_binding_protein_associated_factor_3	0,40	p53	TATA binding protein associated factor 3	7157	83860	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TATA_binding_protein_associated_factor_3 -LRB- TAF3 -RRB- interacts with p53 and inhibits its function .
17693405	0	p53	32,35	TAp73	0,5	p53	TAp73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	TAp73 is a downstream target of p53 in controlling the cellular defense against stress .
23165212	0	p53	92,95	TDG	55,58	p53	TDG	7157	6996	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of thymine_DNA_glycosylase -LRB- TDG -RRB- by the tumor suppressor protein p53 .
25015107	0	p53	15,18	TFF1	0,4	p53	TFF1	22060(Tax:10090)	21784(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	TFF1 activates p53 through down-regulation of miR-504 in gastric_cancer .
27005522	0	p53	25,28	TFIIS.h	0,7	p53	TFIIS.h	7157	6920	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	TFIIS.h , a new target of p53 , regulates transcription efficiency of pro-apoptotic bax gene .
10448271	0	p53	0,3	TGF-beta	79,87	p53	TGF-beta	7157	7040	Gene	Gene	mutations|compound|START_ENTITY induced|nsubj|mutations induced|nmod|END_ENTITY	p53 gene mutations and p21 protein expression induced independently of p53 , by TGF-beta and gamma-rays in squamous_cell_carcinoma cells .
10448271	0	p53	71,74	TGF-beta	79,87	p53	TGF-beta	7157	7040	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	p53 gene mutations and p21 protein expression induced independently of p53 , by TGF-beta and gamma-rays in squamous_cell_carcinoma cells .
12732139	0	p53	33,36	TGF-beta	53,61	p53	TGF-beta	7157	7040	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|responses responses|amod|END_ENTITY	Links between tumor suppressors : p53 is required for TGF-beta gene responses by cooperating with Smads .
17234915	0	p53	55,58	TGF-beta	15,23	p53	TGF-beta	7157	7040	Gene	Gene	phosphorylation|compound|START_ENTITY signaling|nmod|phosphorylation Integration|acl|signaling Integration|nmod|END_ENTITY	Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation .
17875924	0	p53	7,10	TGF-beta	136,144	p53	TGF-beta	7157	7040	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|dobj|transforming_growth_factor_beta1 transforming_growth_factor_beta1|acl|signaling signaling|advcl|repressing repressing|dobj|expression expression|nmod|II II|compound|END_ENTITY	Mutant p53 attenuates the SMAD-dependent transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- signaling pathway by repressing the expression of TGF-beta receptor type II .
18510920	0	p53	0,3	TGF-beta	32,40	p53	TGF-beta	7157	7040	Gene	Gene	regulation|compound|START_ENTITY orchestrates|nsubj|regulation orchestrates|dobj|response response|amod|END_ENTITY	p53 regulation orchestrates the TGF-beta response .
8119773	0	p53	36,39	TGF-beta	55,63	p53	TGF-beta	7157	7040	Gene	Gene	gene|compound|START_ENTITY transduction|nmod|gene increases|nsubj|transduction increases|dobj|expression expression|amod|END_ENTITY	Retroviral-mediated transduction of p53 gene increases TGF-beta expression in a human glioblastoma cell line .
18841476	0	p53	132,135	THP-1	139,144	p53	THP-1	7157	2736	Gene	Gene	START_ENTITY|nmod|macrophages macrophages|compound|END_ENTITY	Apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- and HIF-1alpha protein are essential factors for nitric_oxide-dependent accumulation of p53 in THP-1 human myeloid macrophages .
26247727	0	p53	0,3	TIGAR	39,44	p53	TIGAR	22060(Tax:10090)	319801(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	p53 - and p73-independent activation of TIGAR expression in vivo .
26247727	0	p53	0,3	TIGAR	39,44	p53	TIGAR	22060(Tax:10090)	319801(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	p53 - and p73-independent activation of TIGAR expression in vivo .
11694645	0	p53	102,105	TIMP-1	79,85	p53	TIMP-1	7157	7076	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
11694645	0	p53	102,105	TIMP-2	87,93	p53	TIMP-2	7157	7077	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
10602522	0	p53	73,76	TIMP-3	49,55	p53	TIMP-3	7157	7078	Gene	Gene	mutants|compound|START_ENTITY END_ENTITY|nmod|mutants	Inhibition of the putative tumor suppressor gene TIMP-3 by tumor-derived p53 mutants and wild type p53 .
23178973	0	p53	21,24	TIP30	0,5	p53	TIP30	7157	10553	Gene	Gene	protein|compound|START_ENTITY binds|dobj|protein binds|nsubj|END_ENTITY	TIP30 directly binds p53 tumor suppressor protein in vitro .
26979086	0	p53	111,114	TLR3	88,92	p53	TLR3	7157	7098	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Moraxella_catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells .
25026345	0	p53	130,133	TNF-a	57,62	p53	TNF-a	7157	7124	Gene	Gene	expression|appos|START_ENTITY tumor_necrosis_factor-a|dep|expression tumor_necrosis_factor-a|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
19508870	0	p53	20,23	TOE1	0,4	p53	TOE1	7157	114034	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TOE1 interacts with p53 to modulate its transactivation potential .
16039051	0	p53	6,9	TP53	33,37	p53	TP53	7157	7157	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human p53 tumor suppressor gene -LRB- TP53 -RRB- and schizophrenia : case-control and family studies .
9284922	0	p53	30,33	TP53	40,44	p53	TP53	100682525	100682525	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of Chinese_hamster p53 gene -LRB- TP53 -RRB- to chromosome band 2p31 , a region not involved in the karyotypic changes of a tumorigenic cell line .
9662253	0	p53	53,56	TP53	17,21	p53	TP53	7157	7157	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Mutations in the TP53 gene and protein expression of p53 , MDM 2 and p21/WAF -1 in primary cervical_carcinomas with no or low human_papillomavirus load .
10469621	0	p53	35,38	TPA	89,92	p53	TPA	22060(Tax:10090)	112229(Tax:10090)	Gene	Gene	response|compound|START_ENTITY response|nmod|benzo benzo|acl|-LSB- -LSB-|nmod|END_ENTITY	Thapsigargin has similar effect on p53 protein response to benzo -LSB- a -RSB- pyrene-DNA adducts as TPA in mouse skin .
21964832	0	p53	23,26	TPA	41,44	p53	TPA	7157	5327	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Effect of berberine on p53 expression by TPA in breast_cancer cells .
17139261	0	p53	0,3	TR3	64,67	p53	TR3	7157	3164	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	p53 mediates the negative regulation of MDM2 by orphan receptor TR3 .
21659476	0	p53	29,32	TR3	16,19	p53	TR3	7157	3164	Gene	Gene	transactivation|compound|START_ENTITY enhances|dobj|transactivation enhances|nsubj|END_ENTITY	Orphan receptor TR3 enhances p53 transactivation and represses DNA double-strand break repair in hepatoma cells under ionizing radiation .
22081070	0	p53	94,97	TR3	21,24	p53	TR3	7157	3164	Gene	Gene	expressing|dobj|START_ENTITY signaling|advcl|expressing mTORC1|acl|signaling regulates|dobj|mTORC1 regulates|nsubj|END_ENTITY	The nuclear receptor TR3 regulates mTORC1 signaling in lung_cancer cells expressing wild-type p53 .
19141642	0	p53	123,126	TRAIL	100,105	p53	TRAIL	7157	8743	Gene	Gene	independently|nmod|START_ENTITY independently|compound|END_ENTITY	IFN-alpha-induced apoptosis in hepatocellular_carcinoma involves promyelocytic_leukemia protein and TRAIL independently of p53 .
20368352	0	p53	32,35	TRIM29	10,16	p53	TRIM29	7157	23650	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|protein protein|compound|END_ENTITY	The ATDC -LRB- TRIM29 -RRB- protein binds p53 and antagonizes p53-mediated functions .
21463657	0	p53	28,31	TRIM29	0,6	p53	TRIM29	7157	23650	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TRIM29 negatively regulates p53 via inhibition of Tip60 .
25146927	0	p53	65,68	TRIM32	20,26	p53	TRIM32	7157	22954	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis .
27012201	0	p53	28,31	TRIM65	0,6	p53	TRIM65	7157	201292	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	TRIM65 negatively regulates p53 through ubiquitination .
22262183	0	p53	16,19	TRIM8	0,5	p53	TRIM8	7157	81603	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	TRIM8 modulates p53 activity to dictate cell cycle arrest .
24475287	0	p53	0,3	TRP2	18,22	p53	TRP2	7157	1638	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	p53 regulation by TRP2 is not pervasive in melanoma .
24091941	0	p53	79,82	TTC5	6,10	p53	TTC5	7157	91875	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Human TTC5 , a novel tetratricopeptide repeat domain containing gene , activates p53 and inhibits AP-1 pathway .
10931836	0	p53	95,98	Tax	64,67	p53	Tax	7157	1491938(Tax:11908)	Gene	Gene	rescued|nmod|START_ENTITY rescued|nsubj|Suppression Suppression|nmod|repair repair|nmod|END_ENTITY	Suppression of DNA repair by human T_cell_leukemia_virus_type_1 Tax is rescued by a functional p53 signaling pathway .
11036071	0	p53	77,80	Tax	34,37	p53	Tax	7157	6900	Gene	Gene	inhibition|compound|START_ENTITY pathways|nmod|inhibition utilizes|dobj|pathways utilizes|nsubj|protein protein|compound|END_ENTITY	Human T-lymphotropic virus type I Tax protein utilizes distinct pathways for p53 inhibition that are cell type-dependent .
11080808	0	p53	41,44	Tax	71,74	p53	Tax	7157	6900	Gene	Gene	mechanism|nmod|START_ENTITY Insights|nmod|mechanism inhibition|nsubj|Insights inhibition|nmod|END_ENTITY	Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax .
11160722	0	p53	12,15	Tax	69,72	p53	Tax	22060(Tax:10090)	1491938(Tax:11908)	Gene	Gene	inactivation|compound|START_ENTITY Analysis|nmod|inactivation Analysis|nmod|model model|compound|END_ENTITY	Analysis of p53 inactivation in a human_T-cell_leukemia_virus_type_1 Tax transgenic mouse model .
15155458	0	p53	94,97	Tax	7,10	p53	Tax	7157	6900	Gene	Gene	activity|compound|START_ENTITY inhibition|nmod|activity results|nmod|inhibition interaction|acl:relcl|results induces|dobj|interaction induces|nsubj|END_ENTITY	HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity .
15569630	0	p53	63,66	Tax	45,48	p53	Tax	7157	1491938(Tax:11908)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Setting the stage for transformation : HTLV-1 Tax inhibition of p53 function .
15994832	0	p53	58,61	Tax	127,130	p53	Tax	7157	1491938(Tax:11908)	Gene	Gene	activity|nmod:poss|START_ENTITY repression|nmod|activity Evidence|nmod|repression Evidence|nmod|END_ENTITY	Evidence for NF-kappaB - and CBP-independent repression of p53 's transcriptional activity by human_T-cell_leukemia_virus_type_1 Tax in mouse embryo and primary human fibroblasts .
16308315	0	p53	27,30	Tax	69,72	p53	Tax	7157	6900	Gene	Gene	START_ENTITY|nmod|type type|dep|protein protein|compound|END_ENTITY	Functional inactivation of p53 by human T-cell_leukemia virus type 1 Tax protein : mechanisms and clinical implications .
23633516	0	p53	0,3	Tax	107,110	p53	Tax	22060(Tax:10090)	21367(Tax:10090)	Gene	Gene	dysfunction|compound|START_ENTITY precedes|nsubj|dysfunction precedes|nmod|progression progression|nmod|mice mice|acl|expressing expressing|dobj|END_ENTITY	p53 dysfunction precedes the activation of nuclear factor-kB during disease progression in mice expressing Tax , a human T-cell_leukemia virus type 1 oncoprotein .
7499359	0	p53	30,33	Tax	72,75	p53	Tax	7157	6900	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|protein protein|compound|END_ENTITY	Transcriptional repression of p53 by human T-cell_leukemia virus type I Tax protein .
9445014	0	p53	14,17	Tax	89,92	p53	Tax	7157	1491938(Tax:11908)	Gene	Gene	transactivation|compound|START_ENTITY Inhibition|nmod|transactivation function|nsubj|Inhibition function|nmod|protein protein|compound|END_ENTITY	Inhibition of p53 transactivation function by the human_T-cell_lymphotropic_virus_type_1 Tax protein .
15519514	0	p53	43,46	Thrombospondin-1	0,16	p53	Thrombospondin-1	7157	7057	Gene	Gene	status|compound|START_ENTITY expression|nmod|status expression|amod|END_ENTITY	Thrombospondin-1 expression in relation to p53 status and VEGF expression in human breast_cancers .
15310756	0	p53	52,55	Tip60	39,44	p53	Tip60	7157	10524	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Role of the histone acetyl transferase Tip60 in the p53 pathway .
21463657	0	p53	28,31	Tip60	50,55	p53	Tip60	7157	10524	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	TRIM29 negatively regulates p53 via inhibition of Tip60 .
23576563	0	p53	41,44	Tip60	10,15	p53	Tip60	7157	10524	Gene	Gene	acetylates|dobj|START_ENTITY cofactor|acl:relcl|acetylates cofactor|amod|END_ENTITY	ING5 is a Tip60 cofactor that acetylates p53 in response to DNA damage .
18779317	0	p53	0,3	Toll-like_receptor_3	14,34	p53	Toll-like receptor 3	7157	7098	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	p53 regulates Toll-like_receptor_3 expression and function in human epithelial cell lines .
16969126	0	p53	85,88	Traf4	65,70	p53	Traf4	7157	9618	Gene	Gene	target|compound|START_ENTITY END_ENTITY|appos|target	Identification and characterization of proteins interacting with Traf4 , an enigmatic p53 target .
21898503	0	p53	83,86	Transforming_growth_factor-beta	0,31	p53	Transforming growth factor-beta	22059(Tax:10090)	7040	Gene	Gene	loss|compound|START_ENTITY induced|nmod|loss hepatocarcinogenesis|acl|induced promotes|dobj|hepatocarcinogenesis promotes|nsubj|signaling signaling|compound|END_ENTITY	Transforming_growth_factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss .
9735409	0	p53	85,88	Transforming_growth_factor-beta	0,31	p53	Transforming growth factor-beta	7157	7040	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Transforming_growth_factor-beta enhances the ultraviolet-mediated stress response in p53 - / - keratinocytes .
20226183	0	p53	29,32	Triad_1	0,7	p53	Triad 1	7157	10425	Gene	Gene	activation|compound|START_ENTITY induces|nmod|activation induces|nsubj|END_ENTITY	Triad_1 induces apoptosis by p53 activation .
25832642	0	p53	81,84	Tumor-Suppressor	52,68	p53	Tumor-Suppressor	7157	7248	Gene	Gene	Activity|nmod|START_ENTITY Activity|amod|END_ENTITY	Pseudokinase Tribbles_1 -LRB- TRB1 -RRB- Negatively Regulates Tumor-Suppressor Activity of p53 through p53 Deacetylation .
25179905	0	p53	25,28	Tumor_Suppressor	0,16	p53	Tumor Suppressor	7157	7248	Gene	Gene	Activation|compound|START_ENTITY Activation|compound|END_ENTITY	Tumor_Suppressor Protein p53 Promotes 2-Methoxyestradiol-Induced Activation of Bak and Bax , Leading to Mitochondria-Dependent Apoptosis in Human Colon Cancer HCT116 Cells .
20173470	0	p53	36,39	Tumor_necrosis_factor_alpha	0,27	p53	Tumor necrosis factor alpha	7157	7124	Gene	Gene	modulator|compound|START_ENTITY induces|dobj|modulator induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces p53 up-regulated modulator of apoptosis expression in colorectal_cancer cell lines .
24067374	0	p53	48,51	Tumor_protein_translationally_controlled_1	0,42	p53	Tumor protein translationally controlled 1	22060(Tax:10090)	22070(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	Tumor_protein_translationally_controlled_1 is a p53 target gene that promotes cell survival .
11340094	0	p53	25,28	Tumor_suppressor	0,16	p53	Tumor suppressor	7157	7248	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Tumor_suppressor protein p53 mRNA and subcellular localization are altered by changes in cellular copper in human Hep G2 cells .
22033922	0	p53	55,58	Tumor_suppressor	0,16	p53	Tumor suppressor	7157	7248	Gene	Gene	mRNA|compound|START_ENTITY translation|nmod|mRNA inhibits|dobj|translation inhibits|nsubj|Pdcd4 Pdcd4|amod|END_ENTITY	Tumor_suppressor protein Pdcd4 inhibits translation of p53 mRNA .
7603913	0	p53	22,25	Tumor_suppressor	0,16	p53	Tumor suppressor	7157	7248	Gene	Gene	mutations|compound|START_ENTITY END_ENTITY|dobj|mutations	Tumor_suppressor gene p53 mutations in human prostate_cancer .
20689556	0	p53	7,10	Twist1	30,36	p53	Twist1	7157	7291	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	Mutant p53 -LRB- R175H -RRB- upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells .
11851885	0	p53	43,46	Tyrosinase	0,10	p53	Tyrosinase	7157	7299	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Tyrosinase gene expression is regulated by p53 .
8921390	0	p53	40,43	UBE2I	16,21	p53	UBE2I	7157	7329	Gene	Gene	Associations|nmod|START_ENTITY Associations|nmod|END_ENTITY	Associations of UBE2I with RAD52 , UBL1 , p53 , and RAD51 proteins in a yeast two-hybrid system .
21317885	0	p53	65,68	UBE4B	0,5	p53	UBE4B	7157	10277	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53 .
25875638	0	p53	26,29	UBE4B	39,44	p53	UBE4B	7157	10277	Gene	Gene	Level|compound|START_ENTITY Level|nmod|END_ENTITY	Correction : Regulation of p53 Level by UBE4B in Breast_Cancer .
24831529	0	p53	0,3	USF1	31,35	p53	USF1	22060(Tax:10090)	22278(Tax:10090)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	p53 requires the stress sensor USF1 to direct appropriate cell fate decision .
21522127	0	p53	14,17	USP4	0,4	p53	USP4	22060(Tax:10090)	22258(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1 .
26411366	0	p53	14,17	USP4	0,4	p53	USP4	7157	7375	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	USP4 inhibits p53 and NF-kB through deubiquitinating and stabilizing HDAC2 .
22085928	0	p53	14,17	USP42	72,77	p53	USP42	7157	84132	Gene	Gene	stability|compound|START_ENTITY Regulation|nmod|stability Regulation|nmod|END_ENTITY	Regulation of p53 stability and function by the deubiquitinating enzyme USP42 .
15254178	0	p53	67,70	USP7	76,80	p53	USP7	7157	7874	Gene	Gene	START_ENTITY|nmod|manner manner|amod|END_ENTITY	Herpes_simplex_virus_type_1 infection induces the stabilization of p53 in a USP7 - and ATM-independent manner .
11030150	0	p53	135,138	VEGF	110,114	p53	VEGF	22060(Tax:10090)	7422	Gene	Gene	manner|compound|START_ENTITY promoter|nmod|manner promoter|compound|factor factor|appos|END_ENTITY	Oncogenes and tumor angiogenesis : the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor -LRB- VEGF -RRB- gene promoter in a p53 independent manner .
11710596	0	p53	87,90	VEGF	29,33	p53	VEGF	7157	7422	Gene	Gene	expression|compound|START_ENTITY comparison|nmod|expression study|dep|comparison study|nmod|expression expression|amod|END_ENTITY	Immunohistochemical study on VEGF expression in endometrial_carcinoma -- comparison with p53 expression , angiogenesis , and tumor histologic grade .
11720743	0	p53	112,115	VEGF	50,54	p53	VEGF	7157	7422	Gene	Gene	mutation|compound|START_ENTITY association|nmod|mutation Expression|dep|association Expression|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in non-small_cell_lung_cancer -LRB- NSCLC -RRB- : association with p53 gene mutation and prognosis .
12168898	0	p53	69,72	VEGF	36,40	p53	VEGF	7157	7422	Gene	Gene	expressions|compound|START_ENTITY expression|nmod|expressions expression|nsubj|Vascular_endothelial_growth_factor Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression correlates with p53 and ki-67 expressions in tongue_squamous_cell_carcinoma .
12901974	0	p53	7,10	VEGF	50,54	p53	VEGF	7157	7422	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	Mutant p53 in bone marrow stromal cells increases VEGF expression and supports leukemia cell growth .
15142681	0	p53	107,110	VEGF	0,4	p53	VEGF	7157	7422	Gene	Gene	status|compound|START_ENTITY expression|nmod|status expression|compound|END_ENTITY	VEGF and bFGF expression and microvessel density of maxillary_sinus_squamous_cell_carcinoma in relation to p53 status , spontaneous apoptosis and prognosis .
15142682	0	p53	15,18	VEGF	81,85	p53	VEGF	7157	7422	Gene	Gene	expression|compound|START_ENTITY Correlation|nmod|expression Correlation|nmod|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Correlation of p53 and bcl-2 expression with vascular_endothelial_growth_factor -LRB- VEGF -RRB- , microvessel density -LRB- MVD -RRB- and clinico-pathological features in colon_cancer .
15221598	0	p53	30,33	VEGF	78,82	p53	VEGF	7157	7422	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Correlation and expression of p53 , HER-2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and e-cadherin in a high-risk breast-cancer population .
16432214	0	p53	64,67	VEGF	43,47	p53	VEGF	7157	7422	Gene	Gene	network|compound|START_ENTITY integrates|nmod|network integrates|dobj|system system|compound|END_ENTITY	A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network .
16684540	0	p53	103,106	VEGF	65,69	p53	VEGF	7157	7422	Gene	Gene	activity|compound|START_ENTITY decrease|nmod|activity enhances|nmod|decrease enhances|dobj|expression expression|amod|END_ENTITY	Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity .
16943578	0	p53	10,13	VEGF	38,42	p53	VEGF	7157	7422	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|production production|nmod|END_ENTITY	Antisense p53 decreases production of VEGF in follicular thyroid_cancer cells .
16998811	0	p53	55,58	VEGF	43,47	p53	VEGF	7157	7422	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
18646041	0	p53	51,54	VEGF	18,22	p53	VEGF	7157	7422	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of VEGF is associated with positive p53 immunostaining in hepatocellular_carcinoma -LRB- HCC -RRB- and adverse outcome of HCC patients .
19292920	0	p53	177,180	VEGF	135,139	p53	VEGF	301300(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Gamma-linolenic_acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6_glioma model through changes in VEGF , Flt1 , ERK1/2 , MMP2 , cyclin_D1 , pRb , p53 and p27 protein expression .
23449391	0	p53	0,3	VEGF	13,17	p53	VEGF	7157	7422	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|compound|END_ENTITY	p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway .
26783205	0	p53	79,82	VEGF-R1	56,63	p53	VEGF-R1	7157	2321	Gene	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	The relationship of the angiogenesis regulators VEGF-A , VEGF-R1 and VEGF-R2 to p53 status and prognostic factors in epithelial_ovarian_carcinoma in FIGO-stages I-II .
11313969	0	p53	24,27	VHL	3,6	p53	VHL	7157	7428	Gene	Gene	mirror|dobj|START_ENTITY mirror|nsubj|END_ENTITY	Do VHL and HIF-1 mirror p53 and Mdm-2 ?
16969113	0	p53	27,30	VHL	55,58	p53	VHL	7157	7428	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nsubj|regulation	The positive regulation of p53 by the tumor suppressor VHL .
10951572	0	p53	108,111	VRK1	37,41	p53	VRK1	7157	7443	Gene	Gene	protein|compound|START_ENTITY site|nmod|protein threonine-18|nmod|site phosphorylates|xcomp|threonine-18 phosphorylates|nsubj|vaccinia-related_kinase_1 vaccinia-related_kinase_1|appos|END_ENTITY	The human vaccinia-related_kinase_1 -LRB- VRK1 -RRB- phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein .
18612383	0	p53	98,101	VRK1	47,51	p53	VRK1	7157	7443	Gene	Gene	induced|nmod|START_ENTITY downregulation|acl|induced protect|nmod|downregulation protect|dobj|END_ENTITY	The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53 .
24492002	0	p53	20,23	VRK1	0,4	p53	VRK1	7157	7443	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage .
10779196	0	p53	62,65	Vascular_endothelial_growth_factor	0,34	p53	Vascular endothelial growth factor	7157	7422	Gene	Gene	mutation|compound|START_ENTITY correlates|nmod|mutation correlates|nsubj|expression expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression correlates with p53 mutation and angiogenesis in squamous_cell_carcinoma of the head_and_neck .
12168898	0	p53	69,72	Vascular_endothelial_growth_factor	0,34	p53	Vascular endothelial growth factor	7157	7422	Gene	Gene	expressions|compound|START_ENTITY expression|nmod|expressions expression|nsubj|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression correlates with p53 and ki-67 expressions in tongue_squamous_cell_carcinoma .
10718400	0	p53	24,27	WAF1	36,40	p53	WAF1	7157	1026	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of aberrant p53 and p21 -LRB- WAF1 -RRB- immunoreactivity with the outcome of oral_verrucous_leukoplakia in Taiwan .
10788799	0	p53	54,57	WAF1	31,35	p53	WAF1	7157	1026	Gene	Gene	p21|nmod|START_ENTITY p21|appos|END_ENTITY	IL-1 induces expression of p21 -LRB- WAF1 -RRB- independently of p53 in high-passage human embryonic fibroblasts WI38 .
11080661	0	p53	131,134	WAF1	143,147	p53	WAF1	7157	1026	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	The effect of dibenzo -LSB- a ,1 -RSB- pyrene and benzo -LSB- a -RSB- pyrene on human diploid lung fibroblasts : the induction of DNA adducts , expression of p53 and p21 -LRB- WAF1 -RRB- proteins and cell cycle distribution .
11097743	0	p53	80,83	WAF1	22,26	p53	WAF1	7157	1026	Gene	Gene	WiDr|nmod|START_ENTITY TNF-alpha|dep|WiDr TNF-alpha|acl|induced induced|dobj|p21 p21|appos|END_ENTITY	TNF-alpha induced p21 -LRB- WAF1 -RRB- but not Bax in colon_cancer cells WiDr with mutated p53 : important role of protein stabilization .
11395384	0	p53	0,3	WAF1	100,104	p53	WAF1	7157	1026	Gene	Gene	localization|compound|START_ENTITY arrest|nsubj|localization arrest|nmod|induction induction|nummod|END_ENTITY	p53 cellular localization and function in neuroblastoma : evidence for defective G -LRB- 1 -RRB- arrest despite WAF1 induction in MYCN-amplified cells .
11866928	0	p53	41,44	WAF1	61,65	p53	WAF1	7157	1026	Gene	Gene	protein|compound|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	-LSB- Expression and clinical significance of p53 protein and p21 -LRB- WAF1 -RRB- in non-small-cell lung_carcinoma -RSB- .
12034325	0	p53	38,41	WAF1	50,54	p53	WAF1	7157	1026	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|levels levels|appos|END_ENTITY	Acrylonitrile exposure : the effect on p53 and p21 -LRB- WAF1 -RRB- protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts .
12473386	0	p53	13,16	WAF1	25,29	p53	WAF1	7157	1026	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of p53 and p21 -LRB- WAF1 -RRB- expression on sensitivity of cancer cells to cladribine .
12706118	0	p53	7,10	WAF1	113,117	p53	WAF1	7157	1026	Gene	Gene	delay|nsubj|START_ENTITY delay|advcl|senescing senescing|advcl|reducing reducing|dobj|expression expression|appos|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
12824923	0	p53	101,104	WAF1	151,155	p53	WAF1	7157	1026	Gene	Gene	gene|compound|START_ENTITY gene|nmod|expression expression|appos|END_ENTITY	Enhanced sensitivity to cis-diamminedichloroplatinum -LRB- II -RRB- of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21 -LRB- WAF1 -RRB- expression .
15069711	0	p53	28,31	WAF1	56,60	p53	WAF1	7157	1026	Gene	Gene	START_ENTITY|nmod|gene gene|appos|END_ENTITY	Expression of p21 -LRB- WAF1 -RRB- and p53 and polymorphism of p21 -LRB- WAF1 -RRB- gene in gastric_carcinoma .
16998811	0	p53	55,58	WAF1	87,91	p53	WAF1	7157	1026	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|p21 p21|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17408702	0	p53	56,59	WAF1	68,72	p53	WAF1	7157	1026	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Air pollution by carcinogenic PAHs and plasma levels of p53 and p21 -LRB- WAF1 -RRB- proteins .
18828269	0	p53	58,61	WAF1	78,82	p53	WAF1	7157	1026	Gene	Gene	Bcl-XL|compound|START_ENTITY Bcl-XL|nummod|END_ENTITY	Apoptosis and adenocarcinoma_of_the_cardia : expression of p53 , Bcl-2 , Bcl-XL , WAF1 , and fas proteins and association with characteristics of the tumors .
21368573	0	p53	70,73	WAF1	4,8	p53	WAF1	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	program|compound|START_ENTITY maintains|dobj|program loop|acl:relcl|maintains component|nmod|loop component|nsubj|p21 p21|appos|END_ENTITY	p21 -LRB- WAF1 -RRB- is component of a positive feedback loop that maintains the p53 transcriptional program .
21541527	0	p53	34,37	WAF1	0,4	p53	WAF1	7157	1026	Gene	Gene	alterations|compound|START_ENTITY independent|nmod|alterations independent|nsubj|expression expression|compound|END_ENTITY	WAF1 expression is independent of p53 gene alterations and protein expression in human lung_cancer cells .
21791360	0	p53	82,85	WAF1	45,49	p53	WAF1	7157	1026	Gene	Gene	transcription|nmod|START_ENTITY transcription|appos|END_ENTITY	Human_papillomavirus_type_16 E6 inhibits p21 -LRB- WAF1 -RRB- transcription independently of p53 by inactivating p150 -LRB- Sal2 -RRB- .
24277474	0	p53	46,49	WAF1	40,44	p53	WAF1	7157	1026	Gene	Gene	phenotype|compound|START_ENTITY identify|nsubj|phenotype synthase|parataxis|identify synthase|dep|expression expression|appos|END_ENTITY	Thymidylate synthase expression and p21 -LRB- WAF1 -RRB- / p53 phenotype of colon_cancers identify patients who may benefit from 5-fluorouracil based therapy .
27039754	0	p53	0,3	WAF1	21,25	p53	WAF1	7157	1026	Gene	Gene	START_ENTITY|appos|p21 p21|appos|END_ENTITY	p53 , Cyclin_D1 , p21 -LRB- WAF1 -RRB- and Ki-67 -LRB- MIB1 -RRB- Expression at Invasive Tumour Fronts of Oral_Squamous_Cell_Carcinomas and Development of Local Recurrence .
8242752	0	p53	30,33	WAF1	0,4	p53	WAF1	7157	1026	Gene	Gene	suppression|compound|START_ENTITY mediator|nmod|suppression END_ENTITY|appos|mediator	WAF1 , a potential mediator of p53 tumor suppression .
8731201	0	p53	79,82	WAF1	92,96	p53	WAF1	301300(Tax:10116)	114851(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The effect of ACE inhibitors on the expression of matrix genes and the role of p53 and p21 -LRB- WAF1 -RRB- in experimental renal fibrosis .
8749722	0	p53	135,138	WAF1	81,85	p53	WAF1	7157	1026	Gene	Gene	containing|dobj|START_ENTITY cells|acl|containing mRNA|nmod|cells mRNA|compound|END_ENTITY	Retrovirally mediated wild-type p53 restores S-phase modulation without inducing WAF1 mRNA in breast_carcinoma cells containing mutant p53 .
8749722	0	p53	32,35	WAF1	81,85	p53	WAF1	7157	1026	Gene	Gene	restores|nsubj|START_ENTITY restores|advcl|inducing inducing|dobj|mRNA mRNA|compound|END_ENTITY	Retrovirally mediated wild-type p53 restores S-phase modulation without inducing WAF1 mRNA in breast_carcinoma cells containing mutant p53 .
8941927	0	p53	11,14	WAF1	24,28	p53	WAF1	7157	1026	Gene	Gene	Control|nmod|START_ENTITY Control|appos|END_ENTITY	Control of p53 and p21 -LRB- WAF1 -RRB- expression during unilateral_ureteral_obstruction .
9815858	0	p53	98,101	WAF1	8,12	p53	WAF1	7157	1026	Gene	Gene	mutations|compound|START_ENTITY lacking|dobj|mutations breast_cancers|acl|lacking play|nmod|breast_cancers play|nsubj|genes genes|compound|END_ENTITY	Altered WAF1 genes do not play a role in abnormal cell cycle regulation in breast_cancers lacking p53 mutations .
10712385	0	p53	0,3	WAF1/CIP1	9,18	p53	WAF1/CIP1	7157	1026	Gene	Gene	START_ENTITY|appos|p21 p21|appos|END_ENTITY	p53 , p21 -LRB- WAF1/CIP1 -RRB- , and MDM2 involvement in proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells .
10764661	0	p53	0,3	WAF1/CIP1	9,18	p53	WAF1/CIP1	7157	1026	Gene	Gene	START_ENTITY|appos|p21 p21|appos|END_ENTITY	p53 , p21 -LRB- WAF1/CIP1 -RRB- , and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells .
15735006	0	p53	0,3	WRN	48,51	p53	WRN	7157	7486	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	p53 modulates RPA-dependent and RPA-independent WRN helicase activity .
10634423	0	p53	44,47	WT1	82,85	p53	WT1	7157	7490	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulated expression and potential roles of p53 and Wilms ' _ tumor suppressor gene -LRB- WT1 -RRB- during follicular development in the human ovary .
24490140	0	p53	59,62	WT1	46,49	p53	WT1	7157	7490	Gene	Gene	activity|compound|START_ENTITY enhances|dobj|activity enhances|nsubj|peptide peptide|acl|derived derived|nmod|END_ENTITY	A novel cell-penetrating peptide derived from WT1 enhances p53 activity , induces cell senescence and displays antimelanoma activity in xeno - and syngeneic systems .
7657166	0	p53	32,35	WT1	4,7	p53	WT1	7157	7490	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|product product|compound|END_ENTITY	The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis .
9072005	0	p53	79,82	WT1	0,3	p53	WT1	7157	7490	Gene	Gene	mutation|nmod|START_ENTITY mutation|nsubj|END_ENTITY	WT1 mutation in malignant_mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression , cell-type transition , and prognosis .
9719458	0	p53	0,3	WT1	45,48	p53	WT1	7157	7490	Gene	Gene	mediate|nsubj|START_ENTITY mediate|dobj|expression expression|nmod|gene gene|compound|END_ENTITY	p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines .
17426708	0	p53	31,34	WTH3	0,4	p53	WTH3	7157	84084	Gene	Gene	protein|compound|START_ENTITY target|nmod|protein target|nsubj|END_ENTITY	WTH3 is a direct target of the p53 protein .
12651158	0	p53	104,107	Waf1	77,81	p53	Waf1	7157	1026	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Prolonged progestin treatment induces the promoter of CDK inhibitor p21 Cip1 , Waf1 through activation of p53 in human breast and endometrial_tumor cells .
12925527	0	p53	51,54	Waf1	63,67	p53	Waf1	7157	1026	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	IFI16 as a negative regulator in the regulation of p53 and p21 -LRB- Waf1 -RRB- .
19250907	0	p53	18,21	Wrap53	0,6	p53	Wrap53	7157	55135	Gene	Gene	transcript|compound|START_ENTITY required|nsubj|transcript required|advmod|END_ENTITY	Wrap53 , a natural p53 antisense transcript required for p53 induction upon DNA damage .
19250907	0	p53	56,59	Wrap53	0,6	p53	Wrap53	7157	55135	Gene	Gene	induction|compound|START_ENTITY required|nmod|induction required|advmod|END_ENTITY	Wrap53 , a natural p53 antisense transcript required for p53 induction upon DNA damage .
19571673	0	p53	29,32	Wrap53	0,6	p53	Wrap53	7157	55135	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Wrap53 , a novel regulator of p53 .
24696455	0	p53	25,28	Wrap53	100,106	p53	Wrap53	7157	55135	Gene	Gene	gene|compound|START_ENTITY regulates|dobj|gene regulates|nmod|interaction interaction|nmod|transcript transcript|appos|END_ENTITY	CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript , Wrap53 .
21678496	0	p53	51,54	XIAP-associated_factor_1	0,24	p53	XIAP-associated factor 1	7157	54739	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	XIAP-associated_factor_1 -LRB- XAF1 -RRB- , a novel target of p53 , enhances p53-mediated apoptosis via post-translational modification .
12713809	0	p53	17,20	XPC	81,84	p53	XPC	7157	7508	Gene	Gene	recruitment|compound|START_ENTITY recruitment|nmod|END_ENTITY	Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage .
11950162	0	p53	105,108	Xpa	98,101	p53	Xpa	22060(Tax:10090)	22590(Tax:10090)	Gene	Gene	+|nummod|START_ENTITY END_ENTITY|dep|+	Assessment of carcinogenicity of di -LRB- 2-ethylhexyl -RRB- phthalate in a short-term assay using Xpa - / - and Xpa - / - / p53 + / - mice .
21344396	0	p53	0,3	Y-box_binding_protein_1	66,89	p53	Y-box binding protein 1	7157	4904	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|nmod|END_ENTITY	p53 Suppresses lung_resistance-related_protein expression through Y-box_binding_protein_1 in the MCF-7 breast_tumor cell line .
11175333	0	p53	22,25	YB-1	58,62	p53	YB-1	7157	4904	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Direct interaction of p53 with the Y-box binding protein , YB-1 : a mechanism for regulation of human gene expression .
15210108	0	p53	38,41	Yin_Yang_1	0,10	p53	Yin Yang 1	7157	7528	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Yin_Yang_1 is a negative regulator of p53 .
26843327	0	p53	57,60	Yin_Yang_1	0,10	p53	Yin Yang 1	22060(Tax:10090)	22632(Tax:10090)	Gene	Gene	Downregulating|nummod|START_ENTITY Survival|nmod|Downregulating Survival|compound|END_ENTITY	Yin_Yang_1 Promotes Thymocyte Survival by Downregulating p53 .
10461060	0	p53	74,77	alpha-catenin	38,51	p53	alpha-catenin	7157	1495	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cooccurrence of reduced expression of alpha-catenin and overexpression of p53 is a predictor of lymph_node_metastasis in early gastric_cancer .
17608641	0	p53	65,68	amyloid_precursor_protein	19,44	p53	amyloid precursor protein	7157	351	Gene	Gene	state|nummod|START_ENTITY alters|dobj|state alters|nsubj|Over-expression Over-expression|nmod|END_ENTITY	Over-expression of amyloid_precursor_protein in HEK cells alters p53 conformational state and protects against doxorubicin .
19049493	0	p53	22,25	amyloid_precursor_protein	54,79	p53	amyloid precursor protein	7157	351	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The tumour suppressor p53 regulates the expression of amyloid_precursor_protein -LRB- APP -RRB- .
18084622	0	p53	59,62	androgen_receptor	14,31	p53	androgen receptor	7157	367	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of androgen_receptor is negatively regulated by p53 .
18945670	0	p53	128,131	androgen_receptor	8,25	p53	androgen receptor	7157	367	Gene	Gene	dynamics|nmod|START_ENTITY stress|nmod|dynamics stress|nsubj|Loss Loss|nmod|END_ENTITY	Loss of androgen_receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly -LRB- ADP-ribose -RRB- polymerase PARP-1 .
21997969	0	p53	14,17	androgen_receptor	46,63	p53	androgen receptor	7157	367	Gene	Gene	signaling|compound|START_ENTITY signaling|nmod|END_ENTITY	Activation of p53 signaling and inhibition of androgen_receptor mediate tanshinone_IIA induced G1_arrest in LNCaP_prostate_cancer cells .
22383394	0	p53	14,17	androgen_receptor	82,99	p53	androgen receptor	7157	367	Gene	Gene	expression|compound|START_ENTITY Inhibition|nmod|expression modifies|nsubj|Inhibition modifies|dobj|specificity specificity|nmod|chromatin chromatin|nmod|END_ENTITY	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen_receptor .
23359208	0	p53	145,148	androgen_receptor	109,126	p53	androgen receptor	7157	367	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Anacardic_acid -LRB- 6-pentadecylsalicylic_acid -RRB- induces apoptosis of prostate_cancer cells through inhibition of androgen_receptor and activation of p53 signaling .
23403291	0	p53	84,87	androgen_receptor	66,83	p53	androgen receptor	7157	367	Gene	Gene	axis|nsubj|START_ENTITY sebaceous|parataxis|axis sebaceous|acl:relcl|controlled controlled|nmod|END_ENTITY	c-MYC-induced sebaceous gland differentiation is controlled by an androgen_receptor / p53 axis .
9735408	0	p53	87,90	androgen_receptor	135,152	p53	androgen receptor	7157	367	Gene	Gene	analysis|compound|START_ENTITY analysis|nmod|gene gene|compound|END_ENTITY	Efficacious diagnosis of primary and metastatic human carcinomas with a combination of p53 mutation analysis and clonality analysis of androgen_receptor gene .
27054339	0	p53	61,64	ankyrin-1	33,42	p53	ankyrin-1	7157	286	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration .
20890106	0	p53	88,91	apoB	0,4	p53	apoB	22060(Tax:10090)	238055(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	apoB and apobec1 , two genes key to lipid metabolism , are transcriptionally regulated by p53 .
9865712	0	p53	37,40	atm	8,11	p53	atm	22060(Tax:10090)	11920(Tax:10090)	Gene	Gene	tissues|compound|START_ENTITY radiosensitizes|dobj|tissues radiosensitizes|nsubj|Loss Loss|nmod|END_ENTITY	Loss of atm radiosensitizes multiple p53 null tissues .
16171786	0	p53	40,43	aurora_B	57,65	p53	aurora B	7157	9212	Gene	Gene	START_ENTITY|acl|activated activated|nmod|END_ENTITY	Survivin inhibits anti-growth effect of p53 activated by aurora_B .
10487853	0	p53	81,84	bax	18,21	p53	bax	7157	581	Gene	Gene	motif|nmod|START_ENTITY mutations|nmod|motif associated|nmod|mutations associated|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of bax associated with mutations in the loop-sheet-helix motif of p53 .
10537367	0	p53	136,139	bax	96,99	p53	bax	7157	581	Gene	Gene	levels|compound|START_ENTITY alteration|nmod|levels END_ENTITY|nmod|alteration	Tamoxifen-induced apoptosis in breast_cancer cells relates to down-regulation of bcl-2 , but not bax and bcl-X -LRB- L -RRB- , without alteration of p53 protein levels .
10559267	0	p53	115,118	bax	55,58	p53	bax	7157	581	Gene	Gene	element|compound|START_ENTITY dictated|nmod|element dictated|nsubjpass|mechanism mechanism|nmod|regulation regulation|nmod|promoter promoter|compound|END_ENTITY	One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element .
10559267	0	p53	92,95	bax	55,58	p53	bax	7157	581	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element .
15973073	0	p53	55,58	bax	50,53	p53	bax	7157	581	Gene	Gene	proteins|compound|START_ENTITY expression|appos|proteins expression|appos|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
17145718	0	p53	45,48	bax	130,133	p53	bax	22060(Tax:10090)	12028(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY enhances|dobj|effects enhances|advcl|cooperating cooperating|nmod|trans-activation trans-activation|nmod|expression expression|compound|END_ENTITY	Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression .
27005522	0	p53	25,28	bax	82,85	p53	bax	7157	581	Gene	Gene	target|nmod|START_ENTITY TFIIS.h|appos|target regulates|nsubj|TFIIS.h regulates|dobj|efficiency efficiency|nmod|gene gene|compound|END_ENTITY	TFIIS.h , a new target of p53 , regulates transcription efficiency of pro-apoptotic bax gene .
7834749	0	p53	17,20	bax	72,75	p53	bax	7157	581	Gene	Gene	activator|nsubj|START_ENTITY activator|nmod|gene gene|compound|END_ENTITY	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene .
7970735	0	p53	75,78	bax	13,16	p53	bax	7157	581	Gene	Gene	status|compound|START_ENTITY correlates|nmod|status correlates|nsubj|Induction Induction|nmod|END_ENTITY	Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis .
8183578	0	p53	51,54	bax	33,36	p53	bax	7157	581	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Immediate early up-regulation of bax expression by p53 but not TGF_beta_1 : a paradigm for distinct apoptotic pathways .
9354771	0	p53	10,13	bax	66,69	p53	bax	7157	581	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|up-regulation up-regulation|nmod|expression expression|compound|END_ENTITY	Wild-type p53 induces apoptosis in Hep3B through up-regulation of bax expression .
9389352	11	p53	1578,1581	bax	1656,1659	bax	p53	581	7157	Gene	Gene	gene|compound|START_ENTITY containing|dobj|gene cells|acl|containing Treatment|nmod|cells produce|nsubj|Treatment produce|dobj|changes changes|nmod|END_ENTITY	Treatment of CLL cells containing a wild type p53 gene with CdA , F-ara-A , or CLB , did not produce any consistent changes in bax or bcl-2 .
9546439	0	p53	24,27	bax	71,74	p53	bax	7157	581	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|effects effects|nmod|END_ENTITY	Identification of human p53 mutations with differential effects on the bax and p21 promoters using functional assays in yeast .
9766533	0	p53	83,86	bax	14,17	p53	bax	7157	581	Gene	Gene	expression|compound|START_ENTITY dehydrogenase|nmod|expression dehydrogenase|nsubj|Comparison Comparison|nmod|END_ENTITY	Comparison of bax , waf1 , and IMP dehydrogenase regulation in response to wild-type p53 expression under normal growth conditions .
10231398	0	p53	115,118	bcl-2	0,5	p53	bcl-2	7157	596	Gene	Gene	immunostaining|compound|START_ENTITY irrespective|nmod|immunostaining phenotype|nmod|irrespective associated|nmod|phenotype associated|nsubjpass|expression expression|amod|END_ENTITY	bcl-2 protein expression is associated with a prognostically favourable phenotype in breast_cancer irrespective of p53 immunostaining .
10424692	0	p53	24,27	bcl-2	29,34	p53	bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY mRNAs|nmod|localization mRNAs|nsubj|END_ENTITY	In situ localization of p53 , bcl-2 and bax mRNAs in rat ocular tissue .
10567899	0	p53	7,10	bcl-2	108,113	p53	bcl-2	7157	596	Gene	Gene	genes|amod|START_ENTITY genes|dep|evidence evidence|nmod|link link|nmod|over-expression over-expression|amod|END_ENTITY	c-myc , p53 and bcl-2 , apoptosis-related genes in infiltrating breast_carcinomas : evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients .
10675490	0	p53	22,25	bcl-2	72,77	p53	bcl-2	22060(Tax:10090)	12043(Tax:10090)	Gene	Gene	tumor|compound|START_ENTITY Downregulation|nmod|tumor suppressor|nsubj|Downregulation suppressor|dobj|gene gene|nmod|gene gene|amod|END_ENTITY	Downregulation of the p53 tumor suppressor gene and upregulation of the bcl-2 gene in retinoic_acid_receptor_alpha-deficient transgenic_mice .
10778725	0	p53	47,50	bcl-2	52,57	p53	bcl-2	7157	596	Gene	Gene	Mib-1|compound|START_ENTITY Mib-1|dep|END_ENTITY	Pediatric_medulloblastoma : prognostic value of p53 , bcl-2 , Mib-1 , and microvessel density .
10843472	0	p53	66,69	bcl-2	59,64	p53	bcl-2	7157	596	Gene	Gene	Fas_ligand|dep|START_ENTITY Fas_ligand|dep|END_ENTITY	Apoptosis and apoptosis-related_proteins -LRB- Fas , Fas_ligand , bcl-2 , p53 -RRB- in macrophages of human ovarian_epithelial_tumors .
10861120	0	p53	33,36	bcl-2	38,43	p53	bcl-2	7157	596	Gene	Gene	products|compound|START_ENTITY products|amod|END_ENTITY	-LSB- Radiation-induced apoptosis and p53 , bcl-2 gene expression products in QGY-7703 cell line in vitro -RSB- .
10914720	0	p53	0,3	bcl-2	12,17	p53	bcl-2	7157	596	Gene	Gene	START_ENTITY|nmod|immunostaining immunostaining|amod|END_ENTITY	p53 but not bcl-2 immunostaining is predictive of poor clinical complete response to primary chemotherapy in breast_cancer patients .
10930045	0	p53	55,58	bcl-2	24,29	p53	bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	repression|compound|START_ENTITY involvement|nmod|repression involvement|nmod|suppression suppression|amod|END_ENTITY	Possible involvement of bcl-2 suppression in wild-type p53 gene-dependent cell growth repression in rat_osteosarcoma cells .
10953132	0	p53	0,3	bcl-2	33,38	p53	bcl-2	7157	596	Gene	Gene	accumulation|compound|START_ENTITY accumulation|acl|associated associated|nmod|END_ENTITY	p53 accumulation associated with bcl-2 , the proliferation marker MIB-1 and survival in patients with prostate_cancer subjected to watchful waiting .
11077443	0	p53	0,3	bcl-2	13,18	p53	bcl-2	301300(Tax:10116)	24224(Tax:10116)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|amod|END_ENTITY	p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway .
11091754	0	p53	82,85	bcl-2	14,19	p53	bcl-2	7157	596	Gene	Gene	Protein|compound|START_ENTITY Expression|nmod|Protein Expression|nmod|Protein Protein|amod|END_ENTITY	Expression of bcl-2 Protein in Breast_Carcinoma with Correlation to Expression of p53 Protein and Clinicopathological Factors .
11313951	0	p53	43,46	bcl-2	23,28	p53	bcl-2	7157	596	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Negative regulation of bcl-2 expression by p53 in hematopoietic cells .
11432618	0	p53	20,23	bcl-2	25,30	p53	bcl-2	7157	596	Gene	Gene	HER2|nummod|START_ENTITY HER2|nummod|END_ENTITY	Evaluation of HER2 , p53 , bcl-2 , topoisomerase II-alpha , heat_shock proteins 27 and 70 in primary breast_cancer and metastatic ipsilateral axillary lymph nodes .
11769670	0	p53	46,49	bcl-2	39,44	p53	bcl-2	7157	596	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- A novel antiapoptosis gene , survivin , bcl-2 , p53 expression in cervical_carcinomas -RSB- .
11819301	0	p53	56,59	bcl-2	70,75	p53	bcl-2	7157	596	Gene	Gene	proliferation|appos|START_ENTITY proliferation|amod|END_ENTITY	Apoptosis and its relationship with cell proliferation , p53 , Waf1p21 , bcl-2 and c-myc in esophageal carcinogenesis studied with a high-risk population in northern China .
11820589	0	p53	0,3	bcl-2	11,16	p53	bcl-2	7157	596	Gene	Gene	staining|compound|START_ENTITY staining|amod|END_ENTITY	p53 , MDM2 , bcl-2 staining in follicular_neoplasms of the thyroid gland .
12088454	0	p53	117,120	bcl-2	128,133	p53	bcl-2	7157	596	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Epithelial_neoplasms of the appendix and colorectum : an analysis of cell proliferation , apoptosis , and expression of p53 , CD44 , bcl-2 .
12217802	0	p53	6,9	bcl-2	46,51	p53	bcl-2	7157	596	Gene	Gene	mutations|compound|START_ENTITY lymphomas|nsubj|mutations lymphomas|xcomp|carrying carrying|dobj|rearrangement rearrangement|amod|END_ENTITY	Bcl-6 p53 mutations in lymphomas carrying the bcl-2 / Jh rearrangement .
12479855	0	p53	10,13	bcl-2	54,59	p53	bcl-2	7157	596	Gene	Gene	transduction|compound|START_ENTITY leads|nsubj|transduction leads|xcomp|overexpression overexpression|nmod|resistance resistance|amod|END_ENTITY	Antisense p53 transduction leads to overexpression of bcl-2 and dexamethasone resistance in multiple_myeloma .
12763212	0	p53	34,37	bcl-2	39,44	p53	bcl-2	7157	596	Gene	Gene	significance|appos|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of K-ras , p53 , bcl-2 , PCNA , CD34 in radically resected non-small_cell_lung_cancers .
12796649	0	p53	12,15	bcl-2	17,22	p53	bcl-2	7157	596	Gene	Gene	role|nmod|START_ENTITY confined|nsubj|role confined|nsubj|expression expression|amod|END_ENTITY	The role of p53 , bcl-2 and E-cadherin expression in predicting biochemical relapse for organ confined prostate_cancer in Taiwan .
14663636	0	p53	26,29	bcl-2	36,41	p53	bcl-2	7157	596	Gene	Gene	bax|compound|START_ENTITY bax|nummod|END_ENTITY	Induction of apoptosis by p53 , bax , bcl-2 , and p21 expressed in colorectal_cancer .
15032288	0	p53	69,72	bcl-2	74,79	p53	bcl-2	7157	596	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	The prognostic significance of the immunohistochemical expression of p53 , bcl-2 , c-erb_B-2 and cathepsin-D in ovarian_cancer patients receiving platinum with cyclophosphamide or paclitaxel chemotherapy .
15168338	1	p53	67,70	bcl-2	72,77	p53	bcl-2	7157	596	Gene	Gene	immunohistochemical|dep|START_ENTITY immunohistochemical|amod|END_ENTITY	A TUNEL , p53 , bcl-2 , bag-1 and Bax immunohistochemical study .
15201979	0	p53	43,46	bcl-2	48,53	p53	bcl-2	7157	596	Gene	Gene	expression|nmod|START_ENTITY expression|amod|HER-2 HER-2|amod|END_ENTITY	Relation between HPV-DNA and expression of p53 , bcl-2 , p21WAF-1 , MIB-1 , HER-2 / neu and DNA ploidy in early cervical carcinoma : correlation with clinical outcome .
15973073	0	p53	55,58	bcl-2	35,40	p53	bcl-2	7157	596	Gene	Gene	proteins|compound|START_ENTITY expression|appos|proteins expression|nmod|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
16477877	0	p53	112,115	bcl-2	34,39	p53	bcl-2	7157	596	Gene	Gene	significance|compound|START_ENTITY correlation|nmod|significance expression|dep|correlation expression|nmod|patients patients|amod|END_ENTITY	Immunohistochemical expression of bcl-2 in Dukes ' stage B and C colorectal_carcinoma patients : correlation with p53 and ki-67 in evaluating prognostic significance .
16611376	0	p53	50,53	bcl-2	86,91	p53	bcl-2	7157	596	Gene	Gene	apoptosis|nmod|START_ENTITY related|nmod|apoptosis related|nsubj|Fas Fas|amod|END_ENTITY	In vitro folate_deficiency induces apoptosis by a p53 , Fas -LRB- Apo-1 , CD95 -RRB- independent , bcl-2 related mechanism in phytohaemagglutinin-stimulated human peripheral blood lymphocytes .
17641794	0	p53	45,48	bcl-2	63,68	p53	bcl-2	7157	596	Gene	Gene	immunostains|nmod|START_ENTITY correlation|nmod|immunostains correlation|nmod|expression expression|amod|END_ENTITY	The correlation between the immunostains for p53 and Ki67 with bcl-2 expression and classical prognostic factors in colorectal_carcinomas .
18386458	0	p53	38,41	bcl-2	20,25	p53	bcl-2	7157	596	Gene	Gene	overexpression|compound|START_ENTITY expression|appos|overexpression expression|amod|END_ENTITY	Immunohistochemical bcl-2 expression , p53 overexpression , PR and ER status in endometrial_carcinoma and survival outcomes .
19582475	0	p53	43,46	bcl-2	22,27	p53	bcl-2	7157	596	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Gambogic_acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells .
20591580	0	p53	26,29	bcl-2	31,36	p53	bcl-2	7157	596	Gene	Gene	START_ENTITY|appos|defects defects|amod|END_ENTITY	Apoptosis-related factors p53 , bcl-2 and the defects of force transmission in dilated_cardiomyopathy .
20721457	0	p53	51,54	bcl-2	56,61	p53	bcl-2	7157	596	Gene	Gene	expressions|nmod|START_ENTITY expressions|amod|END_ENTITY	Analysis of the immunohistochemical expressions of p53 , bcl-2 and Ki-67 in colorectal_adenocarcinoma and their correlations with the prognostic factors .
21315022	0	p53	38,41	bcl-2	43,48	p53	bcl-2	7157	596	Gene	Gene	expressions|nmod|START_ENTITY expressions|amod|END_ENTITY	-LSB- Study on the specific expressions of p53 , bcl-2 and c-myc in non-small_cell_lung_cancer with neuroendocrine differentiation -RSB- .
21528323	0	p53	19,22	bcl-2	24,29	p53	bcl-2	7157	596	Gene	Gene	Analysis|appos|START_ENTITY Analysis|appos|expression expression|amod|END_ENTITY	Analysis of K-ras , p53 , bcl-2 and Rb expression in non-small_cell_lung_cancer cell lines .
21695979	0	p53	22,25	bcl-2	27,32	p53	bcl-2	7157	596	Gene	Gene	receptors|dep|START_ENTITY receptors|amod|END_ENTITY	-LSB- Expression of Ki-67 , p53 , bcl-2 , estrogen receptors alpha in patients with clear_cell_renal_carcinoma and epidermal_growth_factor_receptor mutation -RSB- .
22995373	0	p53	60,63	bcl-2	75,80	p53	bcl-2	7157	596	Gene	Gene	bax|compound|START_ENTITY bax|dep|END_ENTITY	Immunohistochemistry with apoptotic-antiapoptotic proteins -LRB- p53 , p21 , bax , bcl-2 -RRB- , c-kit , telomerase , and metallothionein as a diagnostic aid in benign , borderline , and malignant serous and mucinous ovarian_tumors .
23677569	0	p53	102,105	bcl-2	31,36	p53	bcl-2	7157	596	Gene	Gene	activity|compound|START_ENTITY sensitivity|appos|activity compensated|nmod|sensitivity compensated|nsubjpass|suppression suppression|nmod|cells cells|amod|END_ENTITY	Oligonucleotide suppression of bcl-2 in LNCaP cells is compensated by increased androgen sensitivity , p53 and oncogene activity , and suppressed caspase-3 .
24695377	0	p53	79,82	bcl-2	57,62	p53	bcl-2	7157	596	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Interleukin_7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung_cancer cells .
27033900	0	p53	128,131	bcl-2	133,138	p53	bcl-2	7157	596	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27 , p53 , bcl-2 in canine breast_cancer cells .
7867012	0	p53	29,32	bcl-2	41,46	p53	bcl-2	7157	596	Gene	Gene	Human_gliomas|nmod|START_ENTITY express|nsubj|Human_gliomas express|xcomp|END_ENTITY	Human_gliomas with wild-type p53 express bcl-2 .
8183579	0	p53	17,20	bcl-2	39,44	p53	bcl-2	22060(Tax:10090)	12043(Tax:10090)	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|expression expression|amod|END_ENTITY	Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo .
8883414	0	p53	35,38	bcl-2	0,5	p53	bcl-2	7157	596	Gene	Gene	correlates|compound|START_ENTITY combined|nmod|correlates combined|nsubj|overexpression overexpression|amod|END_ENTITY	bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate_cancer .
9158413	0	p53	9,12	bcl-2	0,5	p53	bcl-2	7157	596	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	bcl-2 vs p53 protein expression and apoptotic rate in human nonmelanoma_skin_cancers .
9158704	0	p53	134,137	bcl-2	12,17	p53	bcl-2	7157	596	Gene	Gene	expression|compound|START_ENTITY association|nmod|expression Analysis|dep|association Analysis|nmod|expression expression|amod|END_ENTITY	Analysis of bcl-2 expression in normal , inflamed , dysplastic nasopharyngeal epithelia , and nasopharyngeal_carcinoma : association with p53 expression .
9253035	0	p53	87,90	bcl-2	40,45	p53	bcl-2	7157	596	Gene	Gene	protein|compound|START_ENTITY dependent|nmod|protein dependent|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the antiapoptotic protein bcl-2 is not dependent on the tumor suppressor p53 protein in Indian breast_carcinoma .
9334807	0	p53	82,85	bcl-2	20,25	p53	bcl-2	7157	596	Gene	Gene	breast_carcinomas|nmod|START_ENTITY Interaction|nmod|breast_carcinomas Interaction|nmod|END_ENTITY	Interaction between bcl-2 and p21 -LRB- WAF1/CIP1 -RRB- in breast_carcinomas with wild-type p53 .
9596268	0	p53	27,30	bcl-2	32,37	p53	bcl-2	7157	596	Gene	Gene	vimentin|compound|START_ENTITY vimentin|dep|END_ENTITY	Prognostic significance of p53 , bcl-2 , vimentin , and S100 protein-positive Langerhans cells in endometrial_carcinoma .
9643573	0	p53	0,3	bcl-2	84,89	p53	bcl-2	7157	596	Gene	Gene	mutation|compound|START_ENTITY mutation|nmod|rearrangement rearrangement|amod|END_ENTITY	p53 mutation in a case of blastic transformation of follicular_lymphoma with double bcl-2 rearrangement -LRB- MBR and VCR -RRB- .
9808574	0	p53	162,165	bcl-2	117,122	p53	bcl-2	7157	596	Gene	Gene	START_ENTITY|amod|caspase-3 caspase-3|nmod|evidence evidence|nmod|modulation modulation|amod|END_ENTITY	Flavopiridol induces apoptosis in chronic_lymphocytic_leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53 .
9849490	0	p53	34,37	bcl-2	0,5	p53	bcl-2	7157	596	Gene	Gene	expression|compound|START_ENTITY reciprocal|nmod|expression reciprocal|nsubj|expression expression|amod|END_ENTITY	bcl-2 expression is reciprocal to p53 and c-myc expression in metastatic human colorectal_cancer .
9891509	0	p53	57,60	bcl-2	31,36	p53	bcl-2	7157	596	Gene	Gene	Relevance|nmod|START_ENTITY Relevance|nmod|expression expression|nmod|END_ENTITY	Relevance of the expression of bcl-2 in combination with p53 as a prognostic factor in breast_cancer .
9929161	0	p53	80,83	bcl-2	0,5	p53	bcl-2	7157	596	Gene	Gene	correlation|nmod|START_ENTITY lack|nmod|correlation expression|dep|lack expression|amod|END_ENTITY	bcl-2 protein expression in endometrial_carcinoma : the lack of correlation with p53 .
15973073	0	p53	55,58	bcl-xL	42,48	p53	bcl-xL	7157	598	Gene	Gene	proteins|compound|START_ENTITY expression|appos|proteins expression|appos|END_ENTITY	-LSB- Immunohistochemical expression of bcl-2 , bcl-xL , bax , p53 proteins in gastric_adenoma and adenocarcinoma -RSB- .
10357817	0	p53	70,73	beta-catenin	7,19	p53	beta-catenin	7157	1499	Gene	Gene	accumulation|nmod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	Excess beta-catenin promotes accumulation of transcriptionally active p53 .
10513218	0	p53	154,157	beta-catenin	73,85	p53	beta-catenin	7157	1499	Gene	Gene	-RSB-|compound|START_ENTITY that|nmod|-RSB- comparison|nmod|that relationship|dep|comparison relationship|nmod|atypia atypia|nmod|END_ENTITY	-LSB- The relationship between the histopathological atypia and expression of beta-catenin in colonic_neoplasms resected by endoscopy ; comparison with that of p53 protein -RSB- .
10851067	0	p53	118,121	beta-catenin	79,91	p53	beta-catenin	22060(Tax:10090)	12387(Tax:10090)	Gene	Gene	alleles|nummod|START_ENTITY effect|nmod|alleles effect|amod|END_ENTITY	Hepatocellular_carcinoma in WHV/N-myc 2 transgenic_mice : oncogenic mutations of beta-catenin and synergistic effect of p53 null alleles .
11389839	0	p53	91,94	beta-catenin	56,68	p53	beta-catenin	7157	1499	Gene	Gene	responses|compound|START_ENTITY linked|nmod|responses degradation|acl|linked degradation|amod|END_ENTITY	Siah-1 , SIP , and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses .
11389840	0	p53	65,68	beta-catenin	24,36	p53	beta-catenin	7157	1499	Gene	Gene	linking|dobj|START_ENTITY pathway|acl|linking pathway|amod|END_ENTITY	Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous_polyposis_coli protein .
11532955	0	p53	35,38	beta-catenin	12,24	p53	beta-catenin	22060(Tax:10090)	12387(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Deregulated beta-catenin induces a p53 - and ARF-dependent growth arrest and cooperates with Ras in transformation .
15064706	0	p53	34,37	beta-catenin	70,82	p53	beta-catenin	7157	1499	Gene	Gene	beta-catenin|nmod|START_ENTITY Downregulation|nmod|beta-catenin involves|nsubj|Downregulation involves|dobj|changes changes|nmod|rate rate|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics .
17622616	0	p53	150,153	beta-catenin	101,113	p53	beta-catenin	7157	1499	Gene	Gene	status|nmod|START_ENTITY affects|advcl|status affects|dobj|degradation degradation|nmod|END_ENTITY	Hepatitis_B_virus X protein differentially affects the ubiquitin-mediated proteasomal degradation of beta-catenin depending on the status of cellular p53 .
12028026	0	p53	0,3	c-ABL	77,82	p53	c-ABL	7157	25	Gene	Gene	expression|compound|START_ENTITY associated|nsubjpass|expression associated|nmod|cleavage cleavage|nmod|kinases kinases|amod|END_ENTITY	p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases .
10085066	0	p53	51,54	c-Abl	0,5	p53	c-Abl	7157	25	Gene	Gene	Mdm2|nmod|START_ENTITY effect|nmod|Mdm2 neutralizes|dobj|effect neutralizes|nsubj|END_ENTITY	c-Abl neutralizes the inhibitory effect of Mdm2 on p53 .
10629029	0	p53	15,18	c-Abl	34,39	p53	c-Abl	7157	25	Gene	Gene	DNA|compound|START_ENTITY DNA|amod|binding binding|nmod|END_ENTITY	Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization .
10629029	0	p53	53,56	c-Abl	34,39	p53	c-Abl	7157	25	Gene	Gene	terminus|nummod|START_ENTITY requires|dobj|terminus requires|nsubj|Stimulation Stimulation|nmod|DNA DNA|amod|binding binding|nmod|END_ENTITY	Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization .
10805805	0	p53	83,86	c-Abl	0,5	p53	c-Abl	22060(Tax:10090)	11350(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY context|nmod|deficiency proliferation|nmod|context required|nmod|proliferation required|nsubjpass|END_ENTITY	c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency .
11486026	0	p53	16,19	c-Abl	0,5	p53	c-Abl	7157	25	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination .
12110584	0	p53	60,63	c-Abl	36,41	p53	c-Abl	7157	25	Gene	Gene	regulation|compound|START_ENTITY implications|nmod|regulation phosphorylation|dep|implications phosphorylation|nmod|Mdm2 Mdm2|nmod|END_ENTITY	Tyrosine phosphorylation of Mdm2 by c-Abl : implications for p53 regulation .
15661746	0	p53	38,41	c-Abl	57,62	p53	c-Abl	7157	25	Gene	Gene	DNA|compound|START_ENTITY activation|nmod|DNA Insights|nmod|activation binding|nsubj|Insights binding|nmod|END_ENTITY	Insights into selective activation of p53 DNA binding by c-Abl .
16636310	0	p53	25,28	c-Abl	71,76	p53	c-Abl	7157	25	Gene	Gene	accumulations|nmod|START_ENTITY accompanied|nsubjpass|accumulations accompanied|nmod|reductions reductions|nmod|END_ENTITY	Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells .
17339230	0	p53	71,74	c-Abl	0,5	p53	c-Abl	7157	25	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|kinase kinase|amod|END_ENTITY	c-Abl tyrosine kinase activates p21 transcription via interaction with p53 .
18490454	0	p53	53,56	c-Abl	21,26	p53	c-Abl	7157	25	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Cooperative roles of c-Abl and Cdk5 in regulation of p53 in response to oxidative stress .
19075013	0	p53	61,64	c-Abl	0,5	p53	c-Abl	7157	25	Gene	Gene	Hdmx|nmod|START_ENTITY Hdmx|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	c-Abl phosphorylates Hdmx and regulates its interaction with p53 .
26810274	0	p53	52,55	c-Abl	0,5	p53	c-Abl	22060(Tax:10090)	11350(Tax:10090)	Gene	Gene	apoptosis|nmod|START_ENTITY contributes|nmod|apoptosis contributes|nsubj|END_ENTITY	c-Abl contributes to glucose-promoted apoptosis via p53 signaling pathway in podocytes .
7651743	0	p53	0,3	c-Abl	40,45	p53	c-Abl	7157	25	Gene	Gene	suppression|nummod|START_ENTITY suppression|nmod|tyrosine tyrosine|amod|END_ENTITY	p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase .
11127813	0	p53	43,46	c-Ha-Ras	26,34	p53	c-Ha-Ras	7157	15461(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Direct transactivation of c-Ha-Ras gene by p53 : evidence for its involvement in p53 transactivation activity and p53-mediated apoptosis .
10706102	0	p53	0,3	c-Jun_NH2-terminal_kinase	65,90	p53	c-Jun NH2-terminal kinase	22060(Tax:10090)	26419(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	p53 phosphorylation and association with murine_double_minute_2 , c-Jun_NH2-terminal_kinase , p14ARF , and p300/CBP during the cell cycle and after exposure to ultraviolet irradiation .
22830357	0	p53	92,95	c-MYC	100,105	p53	c-MYC	7157	4609	Gene	Gene	START_ENTITY|nmod|down-regulation down-regulation|amod|END_ENTITY	The over-expression of miR-34a fails to block DoHH2 lymphoma cell proliferation by reducing p53 via c-MYC down-regulation .
8274734	0	p53	19,22	c-MYC	104,109	p53	c-MYC	7157	4609	Gene	Gene	gene|compound|START_ENTITY Alterations|nmod|gene lymphomas|nsubj|Alterations lymphomas|nmod|translocations translocations|nmod|proto-oncogenes proto-oncogenes|amod|END_ENTITY	Alterations of the p53 tumor suppressor gene in diffuse large cell lymphomas with translocations of the c-MYC and BCL-2 proto-oncogenes .
22827438	0	p53	21,24	c-Maf	35,40	p53	c-Maf	22060(Tax:10090)	17132(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|xcomp|END_ENTITY	The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation .
11500059	0	p53	49,52	c-Myb	14,19	p53	c-Myb	7157	4602	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of c-Myb activity by tumor suppressor p53 .
10200458	0	p53	0,3	c-Myc	34,39	p53	c-Myc	301300(Tax:10116)	24577(Tax:10116)	Gene	Gene	mediates|compound|START_ENTITY apoptosis|nsubj|mediates apoptosis|dep|induced induced|nmod|activation activation|amod|END_ENTITY	p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts .
10822369	0	p53	32,35	c-Myc	0,5	p53	c-Myc	7157	4609	Gene	Gene	effect|nmod|START_ENTITY antagonizes|dep|effect antagonizes|amod|END_ENTITY	c-Myc antagonizes the effect of p53 on apoptosis and p21WAF1 transactivation in K562 leukemia cells .
18372915	0	p53	46,49	c-Myc	0,5	p53	c-Myc	22060(Tax:10090)	4609	Gene	Gene	loss|nmod|START_ENTITY cooperate|nmod|loss cooperate|nsubj|END_ENTITY	c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal_tumor family in mice .
19202062	0	p53	0,3	c-Myc	14,19	p53	c-Myc	7157	4609	Gene	Gene	represses|nsubj|START_ENTITY represses|xcomp|END_ENTITY	p53 represses c-Myc through induction of the tumor suppressor miR-145 .
21828057	0	p53	23,26	c-Myc	55,60	p53	c-Myc	7157	4609	Gene	Gene	START_ENTITY|acl|followed followed|nmod|transduction transduction|nmod|END_ENTITY	Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells .
25692307	0	p53	47,50	c-Myc	24,29	p53	c-Myc	7157	4609	Gene	Gene	independently|nmod|START_ENTITY independently|amod|END_ENTITY	Inauhzin -LRB- c -RRB- inactivates c-Myc independently of p53 .
25710583	0	p53	51,54	c-Myc	63,68	p53	c-Myc	7157	4609	Gene	Gene	c-Jun|compound|START_ENTITY c-Jun|nummod|END_ENTITY	The Differential Immunohistochemical Expression of p53 , c-Jun , c-Myc , and p21 Between HCV-related Hepatocellular_Carcinoma With and Without Cirrhosis .
8494784	0	p53	26,29	c-Myc	0,5	p53	c-Myc	7157	4609	Gene	Gene	promoter|compound|START_ENTITY trans-activates|dep|promoter trans-activates|amod|END_ENTITY	c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif .
10871855	0	p53	40,43	c-abl	0,5	p53	c-abl	22060(Tax:10090)	11350(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY involved|nmod|association involved|nsubjpass|END_ENTITY	c-abl is involved in the association of p53 and trk_A .
15378021	0	p53	58,61	c-abl	8,13	p53	c-abl	22060(Tax:10090)	11350(Tax:10090)	Gene	Gene	growth|nmod|START_ENTITY growth|amod|END_ENTITY	Loss of c-abl facilitates anchorage-independent growth of p53 - and RB - _ deficient primary mouse embryonic fibroblasts .
10355531	0	p53	22,25	c-erbB-2	44,52	p53	c-erbB-2	7157	2064	Gene	Gene	Positive|nmod|START_ENTITY Positive|nmod|END_ENTITY	Positive staining for p53 and expression of c-erbB-2 in endosalpinx hyperplasia : analysis of 48 cases and review of literature .
10502729	0	p53	153,156	c-erbB-2	78,86	p53	c-erbB-2	7157	2064	Gene	Gene	accumulation|compound|START_ENTITY detected|nmod|accumulation amplification|acl|detected amplification|amod|END_ENTITY	Genetic alterations in early-onset invasive breast_carcinomas : correlation of c-erbB-2 amplification detected by fluorescence in situ hybridization with p53 accumulation and tumor phenotype .
10621852	0	p53	26,29	c-erbB-2	99,107	p53	c-erbB-2	7157	2064	Gene	Gene	neu|compound|START_ENTITY neu|amod|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
10628345	0	p53	10,13	c-erbB-2	0,8	p53	c-erbB-2	7157	2064	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	c-erbB-2 , p53 protein expression and steroid hormone receptors in breast_carcinomas : an immunohistochemical study .
11240767	0	p53	31,34	c-erbB-2	42,50	p53	c-erbB-2	7157	2064	Gene	Gene	significance|nmod|START_ENTITY significance|amod|END_ENTITY	The prognostic significance of p53 , mdm2 , c-erbB-2 , cathepsin_D , and thrombocytosis in stage_IB_cervical_cancer treated by primary radical hysterectomy .
11819564	0	p53	29,32	c-erbB-2	44,52	p53	c-erbB-2	7157	2064	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Immunohistochemical study on p53 , H-rasp21 , c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients .
12515910	1	p53	130,133	c-erbB-2	154,162	p53	c-erbB-2	7157	2064	Gene	Gene	expression|compound|START_ENTITY Correlation|nmod|expression Correlation|amod|END_ENTITY	Correlation with p53 protein expression , c-erbB-2 , hormone receptors ' status and proliferative activity .
12760717	0	p53	62,65	c-erbB-2	67,75	p53	c-erbB-2	7157	2064	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Helicobacter_pylori_infection affects the expression of PCNA , p53 , c-erbB-2 and Bcl-2 in the human gastric mucosa .
1370701	0	p53	0,3	c-erbB-2	5,13	p53	c-erbB-2	7157	2064	Gene	Gene	START_ENTITY|appos|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|amod|END_ENTITY	p53 , c-erbB-2 and the epidermal_growth_factor_receptor in the benign and malignant prostate .
14598611	0	p53	146,149	c-erbB-2	170,178	p53	c-erbB-2	7157	2064	Gene	Gene	genes|dep|START_ENTITY correlation|appos|genes correlation|appos|END_ENTITY	Immunohistochemical study of apoptosis-related Bcl-2 protein and its correlation with proliferation indices -LRB- Ki67 , PCNA -RRB- , tumor suppressor genes -LRB- p53 , pRb -RRB- , the oncogene c-erbB-2 , sex steroid hormone receptors and other clinicopathological features , in normal , hyperplastic and neoplastic endometrium .
7847827	0	p53	14,17	c-erbB-2	53,61	p53	c-erbB-2	7157	2064	Gene	Gene	gene|compound|START_ENTITY Expression|nmod|gene Expression|appos|proliferation proliferation|amod|END_ENTITY	Expression of p53 tumor suppressor gene , oncoprotein c-erbB-2 , cellular proliferation and differentiation in malignant and benign pancreatic lesions .
7906245	0	p53	70,73	c-erbB-2	60,68	p53	c-erbB-2	7157	2064	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Lymphoepithelioma-like_carcinoma of the uterine cervix with c-erbB-2 , p53 oncoprotein expression and DNA quantification .
7911025	0	p53	33,36	c-erbB-2	46,54	p53	c-erbB-2	7157	2064	Gene	Gene	protein|compound|START_ENTITY detection|nmod|protein detection|appos|protein protein|amod|END_ENTITY	Immunohistochemical detection of p53 protein , c-erbB-2 protein , epidermal_growth_factor_receptor protein and proliferating_cell_nuclear_antigen in gastric_carcinoma .
8102517	0	p53	29,32	c-erbB-2	0,8	p53	c-erbB-2	7157	2064	Gene	Gene	expression|compound|START_ENTITY related|nmod|expression related|nsubj|oncogene oncogene|amod|END_ENTITY	c-erbB-2 oncogene related to p53 expression , cell proliferation and prognosis in breast_cancer .
9042263	0	p53	20,23	c-erbB-2	53,61	p53	c-erbB-2	7157	2064	Gene	Gene	overexpression|compound|START_ENTITY correlated|nsubj|overexpression correlated|nmod|proteins proteins|amod|END_ENTITY	Immunohistochemical p53 overexpression correlated to c-erbB-2 and cathepsin_D proteins in colorectal_cancer .
9167896	0	p53	88,91	c-erbB-2	68,76	p53	c-erbB-2	7157	2064	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Flow cytometric cell cycle kinetics and quantitative measurement of c-erbB-2 and mutant p53 proteins in normal , hyperplastic , and malignant endometrial biopsies .
9387534	0	p53	49,52	c-erbB-2	15,23	p53	c-erbB-2	7157	2064	Gene	Gene	gene|compound|START_ENTITY Expression|nmod|gene Expression|nmod|oncogene oncogene|amod|END_ENTITY	-LSB- Expression of c-erbB-2 oncogene and mutation of p53 gene in myoepithelioma and myoepithelial_carcinoma -RSB- .
9413200	0	p53	0,3	c-erbB-2	5,13	p53	c-erbB-2	7157	2064	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	p53 , c-erbB-2 and p21ras expression in tumor effusion cells of patients with histopathologically different ovarian_neoplasms .
9458364	0	p53	44,47	c-erbB-2	22,30	p53	c-erbB-2	7157	2064	Gene	Gene	.3|nummod|START_ENTITY b72|dep|.3 model|amod|b72 model|amod|END_ENTITY	Altered expression of c-erbB-2 , DF3 , b72 .3 , p53 and Ki-67 with progression and differentiation to two distinct histologic types of invasive_carcinoma in the MCF10AT human xenograft model of proliferative_breast_disease .
9819502	0	p53	64,67	c-erbB-2	103,111	p53	c-erbB-2	7157	2064	Gene	Gene	immunostaining|compound|START_ENTITY immunostaining|amod|END_ENTITY	Prognostic evaluation in supratentorial_astrocytic_tumors using p53 , epidermal_growth_factor_receptor , c-erbB-2 immunostaining .
10641149	0	p53	90,93	c-erbb-2	37,45	p53	c-erbb-2	7157	2064	Gene	Gene	suppressor|appos|START_ENTITY co-expression|appos|suppressor co-expression|nmod|oncoprotein oncoprotein|amod|END_ENTITY	Immunohistochemical co-expression of c-erbb-2 / Neu oncoprotein , altered tumour suppressor -LRB- p53 -RRB- protein , EGF-R and EMA in histological subtypes of infiltrating_duct_carcinoma of the breast .
9920903	0	p53	51,54	c-met	18,23	p53	c-met	7157	4233	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|amod|END_ENTITY	Regulation of the c-met proto-oncogene promoter by p53 .
11212247	0	p53	85,88	c-mos	26,31	p53	c-mos	7157	4342	Gene	Gene	status|compound|START_ENTITY relationship|nmod|status expression|dep|relationship expression|nmod|END_ENTITY	Deregulated expression of c-mos in non-small_cell_lung_carcinomas : relationship with p53 status , genomic instability , and tumor kinetics .
10498900	0	p53	42,45	c-myc	153,158	p53	c-myc	7157	4609	Gene	Gene	sensitizes|compound|START_ENTITY transfer|nmod|sensitizes TNF|nsubj|transfer TNF|nmod|effect effect|dep|relationship relationship|nmod|END_ENTITY	Adenovirus-mediated transfer of wild-type p53 gene sensitizes TNF resistant MCF7 derivatives to the cytotoxic effect of this cytokine : relationship with c-myc and Rb .
10567899	0	p53	7,10	c-myc	0,5	p53	c-myc	7157	4609	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	c-myc , p53 and bcl-2 , apoptosis-related genes in infiltrating breast_carcinomas : evidence of a link between bcl-2 protein over-expression and a lower risk of metastasis and death in operable patients .
1334053	0	p53	42,45	c-myc	47,52	p53	c-myc	7157	4609	Gene	Gene	START_ENTITY|dep|ploidy ploidy|compound|END_ENTITY	Quantitation of biological tumor markers -LRB- p53 , c-myc , Ki-67 and DNA ploidy -RRB- by multiparameter flow cytometry in non-small-cell_lung_cancer .
15839202	0	p53	82,85	c-myc	119,124	p53	c-myc	7157	4609	Gene	Gene	p21|compound|START_ENTITY expression|compound|p21 expression|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Coordination inhibition of the proliferation of MCF-7 by enhancing expression of p53 , p21 and decreasing expression of c-myc -RSB- .
19575869	0	p53	31,34	c-myc	24,29	p53	c-myc	7157	4609	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	-LSB- Abnormal expression of c-myc , p53 , p16 protein and GNAS1 gene mutation in fibrous_dysplasia -RSB- .
22039300	0	p53	2,5	c-myc	132,137	p53	c-myc	22060(Tax:10090)	4609	Gene	Gene	defect|compound|START_ENTITY sensitizes|nsubj|defect sensitizes|nmod|lymphomagenesis lymphomagenesis|nmod|mice mice|acl|carrying carrying|dobj|transgene transgene|amod|END_ENTITY	A p53 defect sensitizes various stages of B cell development to lymphomagenesis in mice carrying an IgH 3 ' regulatory region-driven c-myc transgene .
23177619	0	p53	46,49	c-myc	24,29	p53	c-myc	7157	4609	Gene	Gene	proteins|compound|START_ENTITY analysis|appos|proteins analysis|nmod|WAF/CIP1 WAF/CIP1|amod|END_ENTITY	Correlation analysis of c-myc , p21 -LRB- WAF/CIP1 -RRB- , p53 , C-erbB-2 and COX-2 proteins in esophageal_squamous_cell_carcinoma .
25536625	0	p53	34,37	c-myc	44,49	p53	c-myc	7157	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Immunohistochemical expression of p53 , p63 , c-myc , p21 -LRB- WAF1/cip1 -RRB- and p27 -LRB- kip1 -RRB- proteins in urothelial_bladder_carcinoma : correlation with clinicopathological parameters .
7907610	0	p53	0,3	c-myc	5,10	p53	c-myc	7157	4609	Gene	Gene	START_ENTITY|appos|p62 p62|amod|END_ENTITY	p53 , c-myc p62 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in non-Hodgkin 's _ lymphomas .
8016082	0	p53	50,53	c-myc	0,5	p53	c-myc	7157	4609	Gene	Gene	trafficking|compound|START_ENTITY altering|dobj|trafficking function|advcl|altering function|nsubj|p53 p53|amod|END_ENTITY	c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle .
8547828	0	p53	31,34	c-myc	36,41	p53	c-myc	7157	4609	Gene	Gene	expression|nmod|START_ENTITY Variation|nmod|expression exposed|advcl|Variation exposed|nsubj|oncoproteins oncoproteins|amod|END_ENTITY	Variation in the expression of p53 , c-myc , and bcl-2 oncoproteins in individual patient cultures of normal urothelium exposed to cobalt 60 gamma-rays and N-nitrosodiethanolamine .
8574164	0	p53	0,3	c-myc	15,20	p53	c-myc	7157	4609	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|rearrangements rearrangements|amod|END_ENTITY	p53 mutations , c-myc and bcl-2 rearrangements in human non-Hodgkin 's _ lymphoma cell lines .
9196053	0	p53	105,108	c-myc	40,45	p53	c-myc	7157	4609	Gene	Gene	binding|nmod|START_ENTITY proteins|amod|binding activation|nmod|proteins activation|nmod|gene gene|amod|END_ENTITY	Transcriptional activation of the human c-myc gene by simian_virus_40 large T antigen without binding to p53 and RB proteins in the transient expression system .
9399658	0	p53	14,17	c-myc	87,92	p53	c-myc	7157	4609	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Heterogeneous p53 mutations in a Burkitt_lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements .
9632756	0	p53	53,56	c-myc	14,19	p53	c-myc	7157	4609	Gene	Gene	mutants|compound|START_ENTITY expression|nmod|mutants expression|amod|END_ENTITY	Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain .
9816266	0	p53	149,152	c-myc	22,27	p53	c-myc	7157	4609	Gene	Gene	gene|compound|START_ENTITY mutation|nmod|gene abrogated|nmod|mutation mortality|acl:relcl|abrogated associated|nmod|mortality associated|nsubjpass|Overexpression Overexpression|nmod|proto-oncogene proto-oncogene|amod|END_ENTITY	Overexpression of the c-myc proto-oncogene in colorectal_carcinoma is associated with a reduced mortality that is abrogated by point mutation of the p53 tumor suppressor gene .
11313989	0	p53	0,3	cFLIP	16,21	p53	cFLIP	7157	8837	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|END_ENTITY	p53 upregulates cFLIP , inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells .
15225611	0	p53	67,70	calmodulin_2	33,45	p53	calmodulin 2	7157	816	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Cell type-specific regulation of calmodulin_2 expression by mutant p53 .
23554611	0	p53	43,46	carcinoembryonic_antigen	17,41	p53	carcinoembryonic antigen	7157	1084	Gene	Gene	Ki-67|dep|START_ENTITY Ki-67|compound|END_ENTITY	The potential of carcinoembryonic_antigen , p53 , Ki-67 and glutathion Stransferase - as clinico-histopathological markers for colorectal_cancer .
11129259	0	p53	80,83	caspase-3	27,36	p53	caspase-3	7157	836	Gene	Gene	carrying|dobj|START_ENTITY apoptosis|acl|carrying apoptosis|nmod|activation activation|amod|END_ENTITY	Heat-induced apoptosis via caspase-3 activation in tumour cells carrying mutant p53 .
11346471	0	p53	37,40	caspase-3	16,25	p53	caspase-3	301300(Tax:10116)	25402(Tax:10116)	Gene	Gene	status|compound|START_ENTITY differs|nmod|status differs|nsubj|Contribution Contribution|nmod|END_ENTITY	Contribution of caspase-3 differs by p53 status in apoptosis induced by X-irradiation .
12791380	0	p53	129,132	caspase-3	160,169	p53	caspase-3	22060(Tax:10090)	12367(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|dep|convergence convergence|nmod|activation activation|amod|END_ENTITY	Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression : convergence at caspase-3 activation .
12945745	0	p53	10,13	caspase-3	29,38	p53	caspase-3	7157	836	Gene	Gene	levels|compound|START_ENTITY levels|nmod|activity activity|amod|END_ENTITY	Increased p53 levels without caspase-3 activity and change of cell viability in 6-hydroxydopamine-treated CV1-P cells .
15004518	0	p53	0,3	caspase-3	70,79	p53	caspase-3	7157	836	Gene	Gene	dephosphorylation|compound|START_ENTITY correlate|nsubj|dephosphorylation correlate|nmod|activation activation|amod|END_ENTITY	p53 dephosphorylation and p21 -LRB- Cip1/Waf1 -RRB- translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells .
21307660	0	p53	21,24	caspase-3	62,71	p53	caspase-3	7157	836	Gene	Gene	proteins|compound|START_ENTITY interact|nsubj|proteins interact|nmod|END_ENTITY	Wild-type and mutant p53 proteins interact with mitochondrial caspase-3 .
25108346	0	p53	65,68	caspase-3	99,108	p53	caspase-3	22060(Tax:10090)	12367(Tax:10090)	Gene	Gene	apoptogenesis|nummod|START_ENTITY exhibits|dobj|apoptogenesis exhibits|nmod|activity activity|amod|END_ENTITY	DAO-9 _ -LRB- 2,5-di -LRB- 4-aryloylaryloxymethyl -RRB- -1,3,4 - oxadiazole -RRB- exhibits p53 induced apoptogenesis through caspase-3 mediated endonuclease activity in murine carcinoma .
27064014	0	p53	225,228	caspase-3	169,178	p53	caspase-3	7157	836	Gene	Gene	expression|compound|START_ENTITY levels|appos|expression decreased|nsubj|levels decreased|ccomp|cytotoxic cytotoxic|xcomp|induce induce|nmod|activation activation|amod|END_ENTITY	Isololiolide , a carotenoid metabolite isolated from the brown_alga_Cystoseira_tamariscifolia , is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation , decreased Bcl-2 levels , increased p53 expression and PARP cleavage .
24070868	0	p53	0,3	caspase-6	14,23	p53	caspase-6	22060(Tax:10090)	12368(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|amod|END_ENTITY	p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin .
11896437	0	p53	10,13	caspase-8	79,88	p53	caspase-8	7157	841	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells : role of caspase-8 and mitochondria .
12527914	0	p53	138,141	caspase1	173,181	p53	caspase1	7157	834	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21 -LRB- waf1/cip1 -RRB- .
11240767	0	p53	31,34	cathepsin_D	52,63	p53	cathepsin D	7157	1509	Gene	Gene	significance|nmod|START_ENTITY END_ENTITY|nsubj|significance	The prognostic significance of p53 , mdm2 , c-erbB-2 , cathepsin_D , and thrombocytosis in stage_IB_cervical_cancer treated by primary radical hysterectomy .
8518412	0	p53	0,3	cathepsin_D	20,31	p53	cathepsin D	7157	1509	Gene	Gene	associated|nsubj|START_ENTITY associated|nmod|END_ENTITY	p53 associated with cathepsin_D in primary breast_cancer .
10514438	0	p53	0,3	cdc2	25,29	p53	cdc2	7157	983	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|amod|END_ENTITY	p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor .
11396965	0	p53	98,101	cdc25C	41,47	p53	cdc25C	7157	995	Gene	Gene	down-regulated|nmod|START_ENTITY down-regulated|nsubjpass|END_ENTITY	Expression of the cell cycle phosphatase cdc25C is down-regulated by the tumor suppressor protein p53 but not by p73 .
11046139	0	p53	0,3	cdk4	55,59	p53	cdk4	7157	1019	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|region region|nmod|END_ENTITY	p53 binds selectively to the 5 ' untranslated region of cdk4 , an RNA element necessary and sufficient for transforming_growth_factor_beta - and p53-mediated translational inhibition of cdk4 .
12654916	0	p53	51,54	checkpoint_kinase_2	24,43	p53	checkpoint kinase 2	7157	11200	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Questioning the role of checkpoint_kinase_2 in the p53 DNA damage response .
14516774	0	p53	64,67	checkpoint_kinase_2	30,49	p53	checkpoint kinase 2	22060(Tax:10090)	50883(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Tissue-specific regulation of checkpoint_kinase_2 expression by p53 .
22071692	0	p53	78,81	checkpoint_kinase_2	48,67	p53	checkpoint kinase 2	7157	11200	Gene	Gene	transactivation|compound|START_ENTITY regulates|dobj|transactivation regulates|nsubj|Phosphorylation Phosphorylation|nmod|protein protein|nmod|END_ENTITY	Phosphorylation of von_Hippel-Lindau protein by checkpoint_kinase_2 regulates p53 transactivation .
11019942	0	p53	0,3	cyclin-D1	5,14	p53	cyclin-D1	7157	595	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	p53 , cyclin-D1 , PCNA , AgNOR expression in squamous_cell_cancer_of_the_lip : a multicenter study .
9688185	0	p53	53,56	cyclin-D1	123,132	p53	cyclin-D1	7157	595	Gene	Gene	E2F-1|appos|START_ENTITY Expression|nmod|E2F-1 Expression|dep|correlation correlation|nmod|immunoreactivity immunoreactivity|amod|END_ENTITY	Expression of the cell-cycle-related proteins E2F-1 , p53 , mdm-2 , p21waf-1 , and Ki-67 in multiple myeloma : correlation with cyclin-D1 immunoreactivity .
10051609	0	p53	0,3	cyclin_B1	38,47	p53	cyclin B1	7157	891	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p53 regulates a G2 checkpoint through cyclin_B1 .
12009577	0	p53	134,137	cyclin_B1	22,31	p53	cyclin B1	7157	891	Gene	Gene	caused|nmod|START_ENTITY result|acl:relcl|caused result|nsubj|recognition recognition|nmod|END_ENTITY	Immune recognition of cyclin_B1 as a tumor antigen is a result of its overexpression in human tumors that is caused by non-functional p53 .
15710382	0	p53	0,3	cyclin_B1	63,72	p53	cyclin B1	7157	891	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|transcription transcription|amod|END_ENTITY	p53 is a NF-Y - and p21-independent , Sp1-dependent repressor of cyclin_B1 transcription .
19223507	0	p53	92,95	cyclin_B1	29,38	p53	cyclin B1	7157	891	Gene	Gene	overexpressing|dobj|START_ENTITY tumors|acl|overexpressing responses|nmod|tumors responses|nmod|END_ENTITY	CD8 T-cell responses against cyclin_B1 in breast_cancer patients with tumors overexpressing p53 .
19769738	0	p53	104,107	cyclin_B1	17,26	p53	cyclin B1	22060(Tax:10090)	268697(Tax:10090)	Gene	Gene	tumors|nmod|START_ENTITY development|nmod|tumors development|amod|Immunity Immunity|nmod|delays delays|amod|END_ENTITY	Immunity against cyclin_B1 tumor antigen delays development of spontaneous cyclin_B1-positive tumors in p53 -LRB- - / - -RRB- mice .
25982682	0	p53	89,92	cyclin_B1	62,71	p53	cyclin B1	7157	891	Gene	Gene	function|compound|START_ENTITY function|advmod|independently independently|nmod:npmod|END_ENTITY	Germ_cell_tumors overexpress the candidate therapeutic target cyclin_B1 independently of p53 function .
25982682	0	p53	89,92	cyclin_B1	62,71	p53	cyclin B1	7157	891	Gene	Gene	function|compound|START_ENTITY function|advmod|independently independently|nmod:npmod|END_ENTITY	Germ_cell_tumors overexpress the candidate therapeutic target cyclin_B1 independently of p53 function .
10637437	0	p53	132,135	cyclin_D1	68,77	p53	cyclin D1	7157	595	Gene	Gene	dismutases|compound|START_ENTITY induction|nmod|dismutases involves|dobj|induction involves|nsubj|suppression suppression|nmod|differentiation differentiation|nmod|transfer transfer|amod|END_ENTITY	Tumor suppression without differentiation or apoptosis by antisense cyclin_D1 gene transfer in K1735 melanoma involves induction of p53 , p21WAF1 and superoxide dismutases .
10990069	0	p53	115,118	cyclin_D1	14,23	p53	cyclin D1	7157	595	Gene	Gene	significance|nmod|START_ENTITY Expression|dep|significance Expression|nmod|END_ENTITY	Expression of cyclin_D1 , Ki-67 and PCNA in non-small_cell_lung_cancer : prognostic significance and comparison with p53 and bcl-2 .
11102889	0	p53	84,87	cyclin_D1	113,122	p53	cyclin D1	7157	595	Gene	Gene	START_ENTITY|appos|p16 p16|amod|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11798189	0	p53	0,3	cyclin_D1	51,60	p53	cyclin D1	7157	595	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|down-regulation down-regulation|nmod|expression expression|amod|END_ENTITY	p53 inhibits adriamycin-induced down-regulation of cyclin_D1 expression in human cancer cells .
11838966	0	p53	80,83	cyclin_D1	59,68	p53	cyclin D1	7157	595	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	TSG101 expression in gynecological tumors : relationship to cyclin_D1 , cyclin E , p53 and p16 proteins .
12185899	0	p53	17,20	cyclin_D1	42,51	p53	cyclin D1	7157	595	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	-LSB- Inactivation of p53 and amplification of cyclin_D1 in squamous_cell_carcinomas of the head_and_neck -RSB- .
12378511	0	p53	31,34	cyclin_D1	46,55	p53	cyclin D1	7157	595	Gene	Gene	p27|compound|START_ENTITY p27|dep|END_ENTITY	Expression of G1-S modulators -LRB- p53 , p16 , p27 , cyclin_D1 , Rb -RRB- and Smad4/Dpc4 in intrahepatic_cholangiocarcinoma .
12771941	0	p53	117,120	cyclin_D1	11,20	p53	cyclin D1	22060(Tax:10090)	12443(Tax:10090)	Gene	Gene	heterozygous|nmod|START_ENTITY overexpression|acl:relcl|heterozygous overexpression|amod|END_ENTITY	HBX causes cyclin_D1 overexpression and development of breast_cancer in transgenic animals that are heterozygous for p53 .
12808109	0	p53	0,3	cyclin_D1	14,23	p53	cyclin D1	7157	595	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|transcription transcription|amod|END_ENTITY	p53 represses cyclin_D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone_deacetylase_1 .
15060836	0	p53	164,167	cyclin_D1	34,43	p53	cyclin D1	7157	595	Gene	Gene	Rb|dep|START_ENTITY proteins|dep|Rb correlation|nmod|proteins expression|dep|correlation expression|nmod|E E|amod|END_ENTITY	Immunohistochemical expression of cyclin_D1 , cyclin E , p21/waf1 and p27/kip1 in inflammatory_bowel_disease : correlation with other cell-cycle-related proteins -LRB- Rb , p53 , ki-67 and PCNA -RRB- and clinicopathological features .
15362377	0	p53	120,123	cyclin_D1	143,152	p53	cyclin D1	7157	595	Gene	Gene	START_ENTITY|appos|p27Kip1 p27Kip1|nummod|END_ENTITY	Prognostic factors in survival of patients with stage Ta and T1 bladder urothelial_tumors : the role of G1-S modulators -LRB- p53 , p21Waf1 , p27Kip1 , cyclin_D1 , and cyclin_D3 -RRB- , proliferation index , and clinicopathologic parameters .
16752079	0	p53	155,158	cyclin_D1	95,104	p53	cyclin D1	7157	595	Gene	Gene	START_ENTITY|amod|c-Myc c-Myc|dep|END_ENTITY	Leptin-induced growth of human ZR-75-1 breast_cancer cells is associated with up-regulation of cyclin_D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1 .
17060721	0	p53	19,22	cyclin_D1	29,38	p53	cyclin D1	7157	595	Gene	Gene	esophageal_squamous_cell_carcinoma|compound|START_ENTITY esophageal_squamous_cell_carcinoma|nummod|END_ENTITY	-LSB- The expression of p53 , p16 , cyclin_D1 in esophageal_squamous_cell_carcinoma and esophageal_dysplasia -RSB- .
17935714	0	p53	14,17	cyclin_D1	77,86	p53	cyclin D1	7157	595	Gene	Gene	Abrogation|nmod|START_ENTITY increases|nsubj|Abrogation increases|dobj|END_ENTITY	Abrogation of p53 by its antisense in MCF-7 breast_carcinoma cells increases cyclin_D1 via activation of Akt and promotion of cell proliferation .
19800042	0	p53	22,25	cyclin_D1	55,64	p53	cyclin D1	7157	595	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|amod|END_ENTITY	An inhibitory role of p53 via NF-kappaB element on the cyclin_D1 gene under heat_shock .
21320401	0	p53	80,83	cyclin_D1	45,54	p53	cyclin D1	22060(Tax:10090)	12443(Tax:10090)	Gene	Gene	oncoprotein|nmod|START_ENTITY oncoprotein|amod|END_ENTITY	-LSB- An experimental study on the association of cyclin_D1 oncoprotein with mutated p53 in progressive development of pulmonary_tumors -RSB- .
21590019	0	p53	43,46	cyclin_D1	14,23	p53	cyclin D1	7157	595	Gene	Gene	proteins|compound|START_ENTITY related|nmod|proteins related|nsubj|protein protein|amod|END_ENTITY	Overexpressed cyclin_D1 protein related to p53 and retinoblastoma proteins in transitional_cell_carcinoma_of_the_urinary_tract .
21786090	0	p53	0,3	cyclin_D1	65,74	p53	cyclin D1	7157	595	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|amod|END_ENTITY	p53 and cyclooxygenase-2 expression are directly associated with cyclin_D1 expression in radical prostatectomy specimens of patients with hormone-na ve prostate_cancer .
22315488	0	p53	83,86	cyclin_D1	14,23	p53	cyclin D1	7157	595	Gene	Gene	alterations|compound|START_ENTITY morphology|dep|alterations isoforms|appos|morphology isoforms|amod|END_ENTITY	The impact of cyclin_D1 mRNA isoforms , morphology and p53 in mantle_cell_lymphoma : p53 alterations and blastoid morphology are strong predictors of a high proliferation index .
25225463	0	p53	48,51	cyclin_D1	113,122	p53	cyclin D1	7157	595	Gene	Gene	epidermal|dep|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
7671232	0	p53	0,3	cyclin_D1	38,47	p53	cyclin D1	7157	595	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|synthesis synthesis|amod|END_ENTITY	p53 , through p21 -LRB- WAF1/CIP1 -RRB- , induces cyclin_D1 synthesis .
7784093	0	p53	12,15	cyclin_D1	45,54	p53	cyclin D1	7157	595	Gene	Gene	role|nmod|START_ENTITY role|nmod|expression expression|amod|END_ENTITY	The role of p53 in coordinated regulation of cyclin_D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes .
8641982	0	p53	76,79	cyclin_D1	31,40	p53	cyclin D1	7157	595	Gene	Gene	collaboration|nmod|START_ENTITY collaboration|nmod|gene gene|amod|END_ENTITY	Oncogenic collaboration of the cyclin_D1 -LRB- PRAD1 , bcl-1 -RRB- gene with a mutated p53 and an activated ras oncogene in neoplastic_transformation .
9504605	0	p53	16,19	cyclin_D1	41,50	p53	cyclin D1	7157	595	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|correlate correlate|amod|END_ENTITY	Inactivation of p53 and amplification of cyclin_D1 correlate with clinical outcome in head_and_neck_cancer .
9722210	0	p53	82,85	cyclin_D1	33,42	p53	cyclin D1	7157	595	Gene	Gene	mutation|compound|START_ENTITY Association|nmod|mutation Association|nmod|downregulation downregulation|nmod|END_ENTITY	Association of downregulation of cyclin_D1 and of overexpression of cyclin E with p53 mutation , high tumor grade and poor prognosis in hepatocellular_carcinoma .
9815783	0	p53	87,90	cyclin_D1	27,36	p53	cyclin D1	7157	595	Gene	Gene	abnormalities|compound|START_ENTITY significance|nmod|abnormalities significance|nmod|END_ENTITY	Prognostic significance of cyclin_D1 and retinoblastoma expression in combination with p53 abnormalities in primary , resected non-small_cell_lung_cancers .
10196184	0	p53	133,136	cyclin_G	22,30	p53	cyclin G	7157	900	Gene	Gene	+|compound|START_ENTITY damage|nmod|+ END_ENTITY|nmod|damage	Altered regulation of cyclin_G in human breast_cancer and its specific localization at replication foci in response to DNA damage in p53 + / + cells .
12642871	0	p53	14,17	cyclin_G	36,44	p53	cyclin G	7157	900	Gene	Gene	levels|compound|START_ENTITY levels|nmod|END_ENTITY	Modulation of p53 and p73 levels by cyclin_G : implication of a negative feedback regulation .
15077171	0	p53	47,50	cyclin_G	21,29	p53	cyclin G	7157	900	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	The negative role of cyclin_G in ATM-dependent p53 activation .
7784084	0	p53	116,119	cyclin_G	80,88	p53	cyclin G	301300(Tax:10116)	25405(Tax:10116)	Gene	Gene	sites|nummod|START_ENTITY contains|dobj|sites contains|nsubj|gene gene|amod|END_ENTITY	Identification of p53 target genes through immune selection of genomic DNA : the cyclin_G gene contains two distinct p53 binding sites .
7784084	0	p53	18,21	cyclin_G	80,88	p53	cyclin G	301300(Tax:10116)	25405(Tax:10116)	Gene	Gene	Identification|nmod|START_ENTITY target|nsubj|Identification target|parataxis|contains contains|nsubj|gene gene|amod|END_ENTITY	Identification of p53 target genes through immune selection of genomic DNA : the cyclin_G gene contains two distinct p53 binding sites .
9013707	0	p53	54,57	cyclin_G	18,26	p53	cyclin G	7157	900	Gene	Gene	effectors|nummod|START_ENTITY cyclin_G|nsubj|effectors promotes|parataxis|cyclin_G promotes|nsubj|gene gene|compound|END_ENTITY	The p53-regulated cyclin_G gene promotes cell growth : p53 downstream effectors cyclin_G and Gadd45 exert different effects on cisplatin chemosensitivity .
9013707	0	p53	54,57	cyclin_G	79,87	p53	cyclin G	7157	900	Gene	Gene	effectors|nummod|START_ENTITY END_ENTITY|nsubj|effectors	The p53-regulated cyclin_G gene promotes cell growth : p53 downstream effectors cyclin_G and Gadd45 exert different effects on cisplatin chemosensitivity .
10196169	0	p53	50,53	cyclooxygenase-2	14,30	p53	cyclooxygenase-2	22060(Tax:10090)	19225(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of cyclooxygenase-2 gene expression by p53 .
12469191	0	p53	55,58	cyclooxygenase-2	14,30	p53	cyclooxygenase-2	7157	5743	Gene	Gene	accumulation|compound|START_ENTITY Expression|nmod|accumulation Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 and its relationship to p53 accumulation in ovarian_adenocarcinomas .
14760075	0	p53	78,81	cyclooxygenase-2	9,25	p53	cyclooxygenase-2	7157	5743	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|expression expression|amod|END_ENTITY	Elevated cyclooxygenase-2 expression is associated with altered expression of p53 and SMAD4 , amplification of HER-2 / neu , and poor outcome in serous ovarian_carcinoma .
15287038	0	p53	11,14	cyclooxygenase-2	40,56	p53	cyclooxygenase-2	7157	5743	Gene	Gene	Effects|nmod|START_ENTITY overexpression|nsubj|Effects overexpression|nmod|expression expression|amod|END_ENTITY	Effects of p53 or p27 overexpression on cyclooxygenase-2 gene expression in head_and_neck_squamous_cell_carcinoma cell lines .
15921850	0	p53	79,82	cyclooxygenase-2	14,30	p53	cyclooxygenase-2	7157	5743	Gene	Gene	accumulation|compound|START_ENTITY associated|nmod|accumulation associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 in colorectal_adenocarcinoma is associated with p53 accumulation and hdm2 overexpression .
16733863	0	p53	50,53	cyclooxygenase-2	14,30	p53	cyclooxygenase-2	7157	5743	Gene	Gene	accumulation|compound|START_ENTITY associated|nmod|accumulation associated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant_gallbladder_lesions .
16996907	0	p53	54,57	cyclooxygenase-2	21,37	p53	cyclooxygenase-2	7157	5743	Gene	Gene	analysis|nmod|START_ENTITY analysis|nmod|expression expression|amod|END_ENTITY	Combined analysis of cyclooxygenase-2 expression with p53 and Ki-67 in nonsmall_cell_lung_cancer .
17594159	0	p53	55,58	cyclooxygenase-2	14,30	p53	cyclooxygenase-2	7157	5743	Gene	Gene	accumulation|compound|START_ENTITY Expression|nmod|accumulation Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal_cancers .
19217709	0	p53	8,11	cyclooxygenase-2	32,48	p53	cyclooxygenase-2	7157	5743	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|induction induction|nmod|lines lines|amod|END_ENTITY	Role of p53 in the induction of cyclooxygenase-2 by cisplatin or paclitaxel in non-small cell lung_cancer cell lines .
25225463	0	p53	48,51	cyclooxygenase-2	95,111	p53	cyclooxygenase-2	7157	5743	Gene	Gene	epidermal|dep|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
7515894	0	p53	113,116	cytokeratin_19	126,140	p53	cytokeratin 19	7157	3880	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Analysis of HPV16 E6 and mutant p53-transfected keratinocytes in reconstituted epidermis suggests that wild-type p53 inhibits cytokeratin_19 expression .
19098008	0	p53	22,25	cytokine_receptor	99,116	p53	cytokine receptor	7157	8809	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine_receptor signaling .
15608685	0	p53	105,108	dapk1	0,5	p53	dapk1	7157	1612	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	dapk1 , encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint , is a transcription target of p53 .
15289308	0	p53	0,3	death_receptor_4	16,32	p53	death receptor 4	7157	8797	Gene	Gene	upregulates|nsubj|START_ENTITY upregulates|dobj|expression expression|amod|END_ENTITY	p53 upregulates death_receptor_4 expression through an intronic p53 binding site .
15289308	0	p53	64,67	death_receptor_4	16,32	p53	death receptor 4	7157	8797	Gene	Gene	site|compound|START_ENTITY upregulates|nmod|site upregulates|dobj|expression expression|amod|END_ENTITY	p53 upregulates death_receptor_4 expression through an intronic p53 binding site .
26521214	0	p53	25,28	diacylglycerol_kinase	42,63	p53	diacylglycerol kinase	7157	1607	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Reciprocal regulation of p53 and NF-kB by diacylglycerol_kinase .
10594026	0	p53	8,11	ei24	0,4	p53	ei24	7157	9538	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	ei24 , a p53 response gene involved in growth suppression and apoptosis .
21566906	0	p53	20,23	epidermal_growth-factor_receptor	101,133	p53	epidermal growth-factor receptor	7157	1956	Gene	Gene	expression|compound|START_ENTITY value|nmod|expression value|amod|cathepsin-d cathepsin-d|amod|END_ENTITY	Prognostic value of p53 expression in early-stage breast-carcinoma compared with tumor angiogenesis , epidermal_growth-factor_receptor , C-erbb-2 , cathepsin-d , DNA-ploidy , parameters of cell-kinetics and conventional features .
10621852	0	p53	26,29	epidermal_growth_factor_receptor	65,97	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	neu|compound|START_ENTITY neu|dep|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
10870681	0	p53	165,168	epidermal_growth_factor_receptor	80,112	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	oncogene|iobj|START_ENTITY oncogene|nsubj|analysis analysis|nmod|expression expression|appos|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
11299733	0	p53	120,123	epidermal_growth_factor_receptor	34,66	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	induction|compound|START_ENTITY associated|nmod|induction associated|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of deletion-mutant epidermal_growth_factor_receptor is associated with altered genotoxic stress-provoked p53 mRNA induction in a human glioblastoma cell line .
11546792	0	p53	0,3	epidermal_growth_factor_receptor	28,60	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	p63|compound|START_ENTITY represses|nsubj|p63 represses|dobj|expression expression|compound|END_ENTITY	p53 Homologue p63 represses epidermal_growth_factor_receptor expression .
1355662	0	p53	0,3	epidermal_growth_factor_receptor	80,112	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	expression|compound|START_ENTITY expression|dep|relationship relationship|nmod|expression expression|nmod|END_ENTITY	p53 protein expression in human breast_carcinoma : relationship to expression of epidermal_growth_factor_receptor , c-erbB-2 protein overexpression , and oestrogen receptor .
14670624	0	p53	7,10	epidermal_growth_factor_receptor	105,137	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	protein|compound|START_ENTITY protein|dep|correlation correlation|nmod|level level|nmod|END_ENTITY	Mutant p53 protein in the serum of patients with cervical_carcinoma : correlation with the level of serum epidermal_growth_factor_receptor and prognostic significance .
16632243	0	p53	7,10	epidermal_growth_factor_receptor	133,165	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	protein|compound|START_ENTITY protein|dep|Correlation Correlation|nmod|level level|nmod|END_ENTITY	Mutant p53 protein in the serum of patients with colorectal_cancer : Correlation with the level of carcinoembryonic_antigen and serum epidermal_growth_factor_receptor .
17404024	0	p53	160,163	epidermal_growth_factor_receptor	4,36	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	independent|compound|START_ENTITY cells|nmod|independent proliferation|nmod|cells suppresses|dobj|proliferation suppresses|nsubj|ZD1839 ZD1839|amod|END_ENTITY	The epidermal_growth_factor_receptor tyrosine kinase inhibitor ZD1839 -LRB- Iressa -RRB- suppresses proliferation and invasion of human oral squamous_carcinoma cells via p53 independent and MMP , uPAR dependent mechanism .
18359760	0	p53	80,83	epidermal_growth_factor_receptor	39,71	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	regulates|nmod|START_ENTITY regulates|dobj|transcription transcription|nmod|END_ENTITY	Notch-1 regulates transcription of the epidermal_growth_factor_receptor through p53 .
18391986	0	p53	8,11	epidermal_growth_factor_receptor	20,52	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	Loss|nmod|START_ENTITY induces|nsubj|Loss induces|dobj|activity activity|compound|END_ENTITY	Loss of p53 induces epidermal_growth_factor_receptor promoter activity in normal human keratinocytes .
19716156	0	p53	118,121	epidermal_growth_factor_receptor	84,116	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	status|dep|START_ENTITY status|dep|END_ENTITY	Caveolin-1 expression in diffuse_gliomas : correlation with the proliferation index , epidermal_growth_factor_receptor , p53 , and_1p / 19q status .
25225463	0	p53	48,51	epidermal_growth_factor_receptor	14,46	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	epidermal|dep|START_ENTITY epidermal|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
26820293	0	p53	138,141	epidermal_growth_factor_receptor	74,106	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	domain|compound|START_ENTITY promoted|nmod|domain promoted|nmod|up-regulation up-regulation|nmod|END_ENTITY	Addiction of lung_cancer cells to GOF p53 is promoted by up-regulation of epidermal_growth_factor_receptor through multiple contacts with p53 transactivation domain and promoter .
26820293	0	p53	38,41	epidermal_growth_factor_receptor	74,106	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	GOF|nummod|START_ENTITY cells|nmod|GOF Addiction|nmod|cells promoted|nsubjpass|Addiction promoted|nmod|up-regulation up-regulation|nmod|END_ENTITY	Addiction of lung_cancer cells to GOF p53 is promoted by up-regulation of epidermal_growth_factor_receptor through multiple contacts with p53 transactivation domain and promoter .
7911025	0	p53	33,36	epidermal_growth_factor_receptor	64,96	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	protein|compound|START_ENTITY detection|nmod|protein END_ENTITY|nsubj|detection	Immunohistochemical detection of p53 protein , c-erbB-2 protein , epidermal_growth_factor_receptor protein and proliferating_cell_nuclear_antigen in gastric_carcinoma .
7911031	0	p53	134,137	epidermal_growth_factor_receptor	14,46	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	c-erbB-2|appos|START_ENTITY expression|dep|c-erbB-2 bladder_cancer|nmod|expression Expression|nmod|bladder_cancer Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor_receptor in bladder_cancer as related to established prognostic factors , oncoprotein -LRB- c-erbB-2 , p53 -RRB- expression and long-term prognosis .
8152794	0	p53	16,19	epidermal_growth_factor_receptor	40,72	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|promoter promoter|compound|END_ENTITY	Wild-type human p53 activates the human epidermal_growth_factor_receptor promoter .
8280379	0	p53	15,18	epidermal_growth_factor_receptor	34,66	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|overexpression overexpression|compound|END_ENTITY	Correlation of p53 mutations with epidermal_growth_factor_receptor overexpression and absence of mdm2 amplification in human esophageal_carcinomas .
8887630	0	p53	91,94	epidermal_growth_factor_receptor	40,72	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Transcriptional activation of the human epidermal_growth_factor_receptor promoter by human p53 .
9819502	0	p53	64,67	epidermal_growth_factor_receptor	69,101	p53	epidermal growth factor receptor	7157	1956	Gene	Gene	immunostaining|compound|START_ENTITY immunostaining|dep|END_ENTITY	Prognostic evaluation in supratentorial_astrocytic_tumors using p53 , epidermal_growth_factor_receptor , c-erbB-2 immunostaining .
8001930	0	p53	0,3	erbB-2	12,18	p53	erbB-2	7157	2064	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	p53 but not erbB-2 expression is associated with rapid tumor proliferation in urinary bladder_cancer .
10719737	0	p53	30,33	estrogen_receptor	56,73	p53	estrogen receptor	7157	2099	Gene	Gene	mutations|compound|START_ENTITY mutations|nmod|END_ENTITY	Distinct prognostic values of p53 mutations and loss of estrogen_receptor and their cumulative effect in primary breast_cancers .
10914818	0	p53	152,155	estrogen_receptor	161,178	p53	estrogen receptor	7157	2099	Gene	Gene	START_ENTITY|appos|ER ER|appos|END_ENTITY	Microsatellite alterations on human chromosome 11 in in situ and invasive breast_cancer : a microdissection microsatellite analysis and correlation with p53 , ER -LRB- estrogen_receptor -RRB- , and PR -LRB- progesterone_receptor -RRB- protein immunoreactivity .
15183535	0	p53	15,18	estrogen_receptor	56,73	p53	estrogen receptor	7157	2099	Gene	Gene	polymorphism|compound|START_ENTITY Association|nmod|polymorphism Association|nmod|risk risk|amod|END_ENTITY	Association of p53 genetic polymorphism -LRB- Arg72Pro -RRB- with estrogen_receptor positive breast_cancer risk in Japanese women .
20696891	0	p53	50,53	estrogen_receptor	14,31	p53	estrogen receptor	7157	2099	Gene	Gene	antagonism|nmod|START_ENTITY antagonism|nsubj|Mechanisms Mechanisms|nmod|END_ENTITY	Mechanisms of estrogen_receptor antagonism toward p53 and its implications in breast_cancer therapeutic response and stem cell regulation .
22787161	0	p53	0,3	estrogen_receptor	17,34	p53	estrogen receptor	7157	2099	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	p53 , a target of estrogen_receptor -LRB- ER -RRB- a , modulates DNA damage-induced growth suppression in ER-positive breast_cancer cells .
23242655	0	p53	7,10	estrogen_receptor	20,37	p53	estrogen receptor	7157	2099	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	Mutant p53 binds to estrogen_receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast_cancer cells .
8098318	0	p53	0,3	estrogen_receptor	110,127	p53	estrogen receptor	7157	2099	Gene	Gene	expression|compound|START_ENTITY expression|dep|relationship relationship|nmod|expression expression|nmod|protein protein|compound|END_ENTITY	p53 protein expression in mammary ductal_carcinoma_in_situ : relationship to immunohistochemical expression of estrogen_receptor and c-erbB-2 protein .
9344880	0	p53	21,24	estrogen_receptor	52,69	p53	estrogen receptor	7157	2099	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	The tumor suppressor p53 is a negative regulator of estrogen_receptor signaling pathways .
15012604	0	p53	78,81	estrogen_receptor-alpha	14,37	p53	estrogen receptor-alpha	7157	2099	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of estrogen_receptor-alpha expression by the tumor suppressor gene p53 in MCF-7 cells .
16229810	0	p53	150,153	estrogen_receptor-alpha	3,26	p53	estrogen receptor-alpha	7157	2099	Gene	Gene	effects|nmod|START_ENTITY factors|dep|effects Jun/Fos|dobj|factors activates|ccomp|Jun/Fos END_ENTITY|parataxis|activates	An estrogen_receptor-alpha / p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors : repressive effects of p53 on BRCA-1 transcription .
19351845	0	p53	57,60	estrogen_receptor-alpha	30,53	p53	estrogen receptor-alpha	7157	2099	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of estrogen_receptor-alpha by p53 in human breast_cancer cells .
16112647	0	p53	84,87	eukaryotic_initiation_factor_4E	34,65	p53	eukaryotic initiation factor 4E	7157	1977	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|gene gene|amod|END_ENTITY	Transcriptional repression of the eukaryotic_initiation_factor_4E gene by wild type p53 .
11409876	0	p53	63,66	extracellular_signal-regulated_kinase_2	8,47	p53	extracellular signal-regulated kinase 2	7157	5594	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Nuclear extracellular_signal-regulated_kinase_2 phosphorylates p53 at Thr55 in response to doxorubicin .
11313915	0	p53	18,21	fibroblast_growth_factor_2	37,63	p53	fibroblast growth factor 2	7157	2247	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Tumour suppressor p53 inhibits human fibroblast_growth_factor_2 expression by a post-transcriptional mechanism .
10749144	0	p53	36,39	gadd45	52,58	p53	gadd45	7157	1647	Gene	Gene	required|nmod|START_ENTITY required|nmod|END_ENTITY	A DNA damage signal is required for p53 to activate gadd45 .
16023600	0	p53	89,92	gankyrin	16,24	p53	gankyrin	7157	5716	Gene	Gene	ubiquitylation|nmod|START_ENTITY enhancing|dobj|ubiquitylation binds|xcomp|enhancing binds|nsubj|END_ENTITY	The oncoprotein gankyrin binds to MDM2/HDM2 , enhancing ubiquitylation and degradation of p53 .
16177571	0	p53	51,54	gankyrin	16,24	p53	gankyrin	7157	5716	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The oncoprotein gankyrin negatively regulates both p53 and RB by enhancing proteasomal degradation .
22230478	0	p53	128,131	gankyrin	99,107	p53	gankyrin	7157	5716	Gene	Gene	proliferation|nmod|START_ENTITY proliferation|nmod|cells cells|nmod|downregulation downregulation|nmod|END_ENTITY	Knockdown of HURP inhibits the proliferation of hepacellular_carcinoma cells via downregulation of gankyrin and accumulation of p53 .
11707411	0	p53	22,25	hADA3	0,5	p53	hADA3	7157	10474	Gene	Gene	activity|compound|START_ENTITY required|nmod|activity required|nsubjpass|END_ENTITY	hADA3 is required for p53 activity .
17452980	0	p53	31,34	hAda3	0,5	p53	hAda3	7157	10474	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	hAda3 regulates p14ARF-induced p53 acetylation and senescence .
27034006	0	p53	122,125	hBD3	72,76	p53	hBD3	7157	55894	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Human_papillomavirus oncogenic E6 protein regulates human b-defensin 3 -LRB- hBD3 -RRB- expression via the tumor suppressor protein p53 .
22916232	0	p53	44,47	hDM2	72,76	p53	hDM2	7157	28508	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Modeling of arylamide helix mimetics in the p53 peptide binding site of hDM2 suggests parallel and anti-parallel conformations are both stable .
19415930	0	p53	53,56	hDMX	74,78	p53	hDMX	7157	4193	Gene	Gene	hDM2|nummod|START_ENTITY inhibitors|nmod|hDM2 Improvement|nmod|inhibitors END_ENTITY|nmod|Improvement	In Silico Improvement of beta3-peptide inhibitors of p53 x hDM2 and p53 x hDMX .
16924240	0	p53	56,59	hHR23B	0,6	p53	hHR23B	7157	5887	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	hHR23B is required for genotoxic-specific activation of p53 and apoptosis .
12750285	0	p53	0,3	hRAD51	19,25	p53	hRAD51	7157	5888	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	p53 interacts with hRAD51 and hRAD54 , and directly modulates homologous recombination .
17018602	0	p53	102,105	hdm2	14,18	p53	hdm2	7157	4193	Gene	Gene	stability|compound|START_ENTITY correlating|nmod|stability Regulation|acl|correlating Regulation|nmod|END_ENTITY	Regulation of hdm2 by stress-induced hdm2alt1 in tumor and nontumorigenic cell lines correlating with p53 stability .
9430646	0	p53	81,84	hdm2	36,40	p53	hdm2	7157	4193	Gene	Gene	protein|compound|START_ENTITY levels|nmod|protein regulates|dobj|levels regulates|nsubj|shuttling shuttling|nmod|oncoprotein oncoprotein|amod|END_ENTITY	Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human_immunodeficiency_virus rev protein .
15735006	0	p53	0,3	helicase	52,60	p53	helicase	7157	164045	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	p53 modulates RPA-dependent and RPA-independent WRN helicase activity .
16474844	0	p53	17,20	heparanase	31,41	p53	heparanase	7157	10855	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Tumor suppressor p53 regulates heparanase gene expression .
11296226	0	p53	0,3	heparin-binding_EGF-like_growth_factor	17,55	p53	heparin-binding EGF-like growth factor	7157	1839	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	p53 induction of heparin-binding_EGF-like_growth_factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades .
11296226	0	p53	68,71	heparin-binding_EGF-like_growth_factor	17,55	p53	heparin-binding EGF-like growth factor	7157	1839	Gene	Gene	suppression|compound|START_ENTITY counteracts|dobj|suppression counteracts|nsubj|induction induction|nmod|END_ENTITY	p53 induction of heparin-binding_EGF-like_growth_factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades .
22391568	0	p53	47,50	histone_deacetylase_8	69,90	p53	histone deacetylase 8	7157	55869	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|END_ENTITY	Histone deacetylase inhibitors suppress mutant p53 transcription via histone_deacetylase_8 .
16360036	0	p53	59,62	hnRNP_K	0,7	p53	hnRNP K	7157	3190	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	hnRNP_K : an HDM2 target and transcriptional coactivator of p53 in response to DNA damage .
11740489	0	p53	14,17	homeodomain-interacting_protein_kinase-2	51,91	p53	homeodomain-interacting protein kinase-2	7157	28996	Gene	Gene	activity|compound|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of p53 activity by its interaction with homeodomain-interacting_protein_kinase-2 .
18483253	0	p53	36,39	homeodomain-interacting_protein_kinase-2	50,90	p53	homeodomain-interacting protein kinase-2	7157	28996	Gene	Gene	START_ENTITY|nmod|knockdown knockdown|amod|END_ENTITY	Reversible dysfunction of wild-type p53 following homeodomain-interacting_protein_kinase-2 knockdown .
12907596	0	p53	78,81	homeodomain-interacting_protein_kinase_2	20,60	p53	homeodomain-interacting protein kinase 2	7157	28996	Gene	Gene	phosphorylation|compound|START_ENTITY END_ENTITY|dep|phosphorylation	PML is required for homeodomain-interacting_protein_kinase_2 -LRB- HIPK2 -RRB- - mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains .
3285177	0	p53	153,156	hsc70	126,131	p53	hsc70	22060(Tax:10090)	24468(Tax:10116)	Gene	Gene	dissociation|nmod|START_ENTITY dissociation|nmod|END_ENTITY	Purification of complexes of nuclear oncogene p53 with rat and Escherichia_coli heat_shock proteins : in vitro dissociation of hsc70 and dnaK from murine p53 by ATP .
1567424	0	p53	93,96	hsp70	0,5	p53	hsp70	7157	3308	Gene	Gene	region|nmod|START_ENTITY derived|nmod|region peptide|acl|derived binds|nmod|peptide binds|nsubj|END_ENTITY	hsp70 binds specifically to a peptide derived from the highly conserved domain -LRB- I -RRB- region of p53 .
7828728	0	p53	115,118	hsp70	20,25	p53	hsp70	7157	3308	Gene	Gene	expressing|dobj|START_ENTITY cells|acl|expressing Interaction|nmod|cells Interaction|nmod|END_ENTITY	Interaction between hsp70 and hsp40 , eukaryotic homologues of DnaK and DnaJ , in human cells expressing mutant-type p53 .
8418500	0	p53	42,45	hsp70	24,29	p53	hsp70	7157	3308	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|promoter promoter|amod|END_ENTITY	Regulation of the human hsp70 promoter by p53 .
10464705	0	p53	127,130	hsp72	63,68	p53	hsp72	22060(Tax:10090)	193740(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY status|nmod|gene L|nmod|status L|nsubj|incidence incidence|nmod|apoptosis apoptosis|nmod|proteins proteins|compound|END_ENTITY	Thermosensitivity , incidence of apoptosis and accumulations of hsp72 and p53 proteins of murine L cells in wild type status of p53 gene .
9696931	0	p53	14,17	hsp72	49,54	p53	hsp72	7157	3303	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of p53 , bcl-2 and heat_shock_protein -LRB- hsp72 -RRB- in malignant_and_benign_ovarian_tumours .
11507088	0	p53	50,53	hsp90	22,27	p53	hsp90	7157	3320	Gene	Gene	stabilization|compound|START_ENTITY contributes|nmod|stabilization contributes|nsubj|Inhibition Inhibition|nmod|MDM2 MDM2|nmod|END_ENTITY	Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization .
15145929	0	p53	25,28	hsp90	94,99	p53	hsp90	7157	3320	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation .
15284248	0	p53	32,35	hsp90beta	14,23	p53	hsp90beta	7157	3326	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells .
17391696	0	p53	68,71	iASPP	37,42	p53	iASPP	7157	10848	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of a novel isoform of iASPP and its interaction with p53 .
17906639	0	p53	39,42	iASPP	101,106	p53	iASPP	7157	10848	Gene	Gene	acetylation|compound|START_ENTITY acetylation|nmod|END_ENTITY	The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP .
22552744	0	p53	141,144	iASPP	148,153	p53	iASPP	7157	10848	Gene	Gene	apoptosis|nmod|START_ENTITY apoptosis|nmod|END_ENTITY	Abnormal expression pattern of the ASPP family of proteins in human non-small_cell_lung_cancer and regulatory functions on apoptosis through p53 by iASPP .
10842159	0	p53	199,202	iNOS	33,37	p53	iNOS	301300(Tax:10116)	24599(Tax:10116)	Gene	Gene	kinase|nmod|START_ENTITY vascular|nmod|kinase vascular|nsubj|upregulates upregulates|appos|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic_guanosine_monophosphate .
12100521	0	p53	13,16	iNOS	7,11	p53	iNOS	7157	4843	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Bcl-2 , iNOS , p53 and PCNA expression in normal , disordered proliferative , hyperplastic and malignant endometrium .
26794389	0	p53	25,28	ink4a	37,42	p53	ink4a	7157	1029	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Clinical Significance of p53 and p16 -LRB- ink4a -RRB- Status in a Contemporary North American Penile_Carcinoma Cohort .
9492043	0	p53	164,167	insulin-like_growth_factor-I	14,42	p53	insulin-like growth factor-I	7157	3479	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|dep|interaction	p53 regulates insulin-like_growth_factor-I -LRB- IGF-I -RRB- _ receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line : interaction between p53 and Sp1 .
10949925	0	p53	86,89	insulin-like_growth_factor_II	18,47	p53	insulin-like growth factor II	7157	3481	Gene	Gene	249|compound|START_ENTITY transcription|nmod|249 transcription|amod|END_ENTITY	Activation of the insulin-like_growth_factor_II transcription by aflatoxin_B1 induced p53 mutant 249 is caused by activation of transcription complexes ; implications for a gain-of-function during the formation of hepatocellular_carcinoma .
9502429	0	p53	0,3	insulin-like_growth_factor_II	20,49	p53	insulin-like growth factor II	7157	3481	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	p53 regulates human insulin-like_growth_factor_II gene expression through active P4 promoter in rhabdomyosarcoma cells .
8665514	0	p53	81,84	insulin_receptor	18,34	p53	insulin receptor	7157	3643	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Repression of the insulin_receptor promoter by the tumor suppressor gene product p53 : a possible mechanism for receptor overexpression in breast_cancer .
25026345	0	p53	130,133	intercellular_adhesion_molecule-1	86,119	p53	intercellular adhesion molecule-1	7157	3383	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
11830554	0	p53	92,95	interleukin-6	10,23	p53	interleukin-6	7157	3569	Gene	Gene	involvement|nmod|START_ENTITY evidence|nmod|involvement production|dep|evidence production|amod|END_ENTITY	Autocrine interleukin-6 production in renal_cell_carcinoma : evidence for the involvement of p53 .
1852210	0	p53	10,13	interleukin-6	80,93	p53	interleukin-6	22060(Tax:10090)	16193(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|apoptosis apoptosis|acl:relcl|inhibited inhibited|advcl|END_ENTITY	Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 .
23675777	0	p53	53,56	interleukin-6	25,38	p53	interleukin-6	22060(Tax:10090)	16193(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of myocardial interleukin-6 expression by p53 and STAT1 .
8247009	0	p53	29,32	interleukin-6	36,49	p53	interleukin-6	7157	3569	Gene	Gene	START_ENTITY|nmod|effects effects|amod|END_ENTITY	Complementation by wild-type p53 of interleukin-6 effects on M1 cells : induction of cell cycle exit and cooperativity with c-myc suppression .
8325885	0	p53	111,114	interleukin-6	24,37	p53	interleukin-6	7157	3569	Gene	Gene	species|compound|START_ENTITY activity|nmod|species _|dobj|activity C/EBP|xcomp|_ C/EBP|nsubj|Modulation Modulation|nmod|promoter promoter|amod|END_ENTITY	Modulation of the human interleukin-6 promoter -LRB- IL-6 -RRB- and transcription factor C/EBP _ beta -LRB- NF-IL6 -RRB- activity by p53 species .
10449033	0	p53	25,28	jun_N-terminal_kinase	63,84	p53	jun N-terminal kinase	301300(Tax:10116)	116554(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY status|nmod|gene modulates|nsubj|status modulates|dobj|level level|nmod|END_ENTITY	Mutational status of the p53 gene modulates the basal level of jun_N-terminal_kinase and its inducibility by ultraviolet irradiation in A1-5 rat fibroblasts .
11783085	0	p53	39,42	latent_membrane_protein_1	5,30	p53	latent membrane protein 1	7157	9260	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	-LSB- EBV latent_membrane_protein_1 induces p53 expression via NF-kappa_B in nasopharyngeal_carcinoma -RSB- .
23942113	0	p53	51,54	legumain	34,42	p53	legumain	7157	5641	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|compound|END_ENTITY	Transcriptional regulation of the legumain gene by p53 in HCT116 cells .
21344396	0	p53	0,3	lung_resistance-related_protein	15,46	p53	lung resistance-related protein	7157	9961	Gene	Gene	Suppresses|nsubj|START_ENTITY Suppresses|dobj|expression expression|amod|END_ENTITY	p53 Suppresses lung_resistance-related_protein expression through Y-box_binding_protein_1 in the MCF-7 breast_tumor cell line .
12847682	0	p53	14,17	macrophage_migration_inhibitory_factor	21,59	p53	macrophage migration inhibitory factor	22060(Tax:10090)	17319(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of p53 by macrophage_migration_inhibitory_factor in inflammatory_arthritis .
20922580	0	p53	97,100	macrophage_migration_inhibitory_factor	36,74	p53	macrophage migration inhibitory factor	7157	4282	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinicopathological significance of macrophage_migration_inhibitory_factor and its relation with p53 in gastric_cancer .
19229245	0	p53	51,54	malate_dehydrogenase	20,40	p53	malate dehydrogenase	7157	4199	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	A nucleocytoplasmic malate_dehydrogenase regulates p53 transcriptional activity in response to metabolic stress .
11602639	0	p53	163,166	mammalian_target_of_rapamycin	88,117	p53	mammalian target of rapamycin	7157	2475	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	Human_immunodeficiency_virus_1 envelope glycoprotein complex-induced apoptosis involves mammalian_target_of_rapamycin / FKBP12-rapamycin-associated_protein-mediated p53 phosphorylation .
10692390	0	p53	0,3	maspin	58,64	p53	maspin	7157	5268	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	p53 regulates the expression of the tumor suppressor gene maspin .
12184537	0	p53	61,64	maspin	14,20	p53	maspin	7157	5268	Gene	Gene	expression|compound|START_ENTITY relationship|nmod|expression Expression|dep|relationship Expression|nmod|END_ENTITY	Expression of maspin in colon_cancers : its relationship with p53 expression and microvessel density .
15492782	0	p53	99,102	maspin	8,14	p53	maspin	7157	5268	Gene	Gene	abnormality|compound|START_ENTITY associated|nmod|abnormality associated|nsubjpass|Loss Loss|nmod|expression expression|compound|END_ENTITY	Loss of maspin expression is associated with development and progression of gastric_carcinoma with p53 abnormality .
15578720	0	p53	30,33	maspin	64,70	p53	maspin	7157	5268	Gene	Gene	substitute|nmod|START_ENTITY substitute|advcl|inducing inducing|dobj|expression expression|nmod|suppressor suppressor|compound|END_ENTITY	TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor .
17204482	0	p53	15,18	maspin	129,135	p53	maspin	7157	5268	Gene	Gene	Convergence|nmod|START_ENTITY Convergence|acl|END_ENTITY	Convergence of p53 and transforming_growth_factor_beta -LRB- TGFbeta -RRB- signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells .
10206959	0	p53	0,3	matrix_metalloproteinase-1	25,51	p53	matrix metalloproteinase-1	7157	4312	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|expression expression|amod|END_ENTITY	p53 down-regulates human matrix_metalloproteinase-1 -LRB- Collagenase-1 -RRB- gene expression .
10392633	0	p53	43,46	mdm-2	0,5	p53	mdm-2	7157	4193	Gene	Gene	status|compound|START_ENTITY correlates|nmod|status correlates|nsubj|expression expression|amod|END_ENTITY	mdm-2 expression correlates with wild-type p53 status in esophageal_adenocarcinoma .
10951572	0	p53	108,111	mdm-2	82,87	p53	mdm-2	7157	4193	Gene	Gene	protein|compound|START_ENTITY site|nmod|protein site|amod|END_ENTITY	The human vaccinia-related_kinase_1 -LRB- VRK1 -RRB- phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein .
10963109	1	p53	57,60	mdm-2	62,67	p53	mdm-2	7157	4193	Gene	Gene	Correlation|nmod|START_ENTITY indices|advcl|Correlation indices|nsubj|proteins proteins|amod|END_ENTITY	Correlation with p53 , mdm-2 , Rb proteins and proliferation indices .
1535557	0	p53	52,55	mdm-2	4,9	p53	mdm-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY forms|nmod|protein forms|nsubj|product product|amod|END_ENTITY	The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation .
21556561	0	p53	88,91	mdm-2	14,19	p53	mdm-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	harboring|dobj|START_ENTITY variants|xcomp|harboring variants|nsubj|Status Status|nmod|genes genes|amod|END_ENTITY	Status of the mdm-2 and waf-1 genes in mouse epidermal jb6 variants harboring wild-type p53 - a p53-independent induction of waf-1 .
7646765	0	p53	0,3	mdm-2	49,54	p53	mdm-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	mutation|nsubj|START_ENTITY mutation|nmod|loss loss|nmod|amplification amplification|amod|END_ENTITY	p53 mutation without allelic loss and absence of mdm-2 amplification in a transplantable hamster pancreatic_ductal_adenocarcinoma and derived cell lines but not primary ductal_adenocarcinomas in hamsters .
7926727	0	p53	39,42	mdm-2	121,126	p53	mdm-2	7157	4193	Gene	Gene	domain|compound|START_ENTITY amino_acids|nmod|domain required|nsubjpass|amino_acids required|nmod|activation activation|amod|END_ENTITY	Several hydrophobic amino_acids in the p53 amino-terminal domain are required for transcriptional activation , binding to mdm-2 and the adenovirus 5 E1B 55-kD protein .
8152809	0	p53	109,112	mdm-2	4,9	p53	mdm-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY line|acl|expressing translocated|nmod|line translocated|nsubjpass|oncogene oncogene|amod|END_ENTITY	The mdm-2 oncogene is translocated and overexpressed in a murine plasmacytoma cell line expressing wild-type p53 .
8361769	0	p53	76,79	mdm-2	16,21	p53	mdm-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	tolerating|dobj|START_ENTITY Upregulation|acl|tolerating Upregulation|nmod|expression expression|amod|END_ENTITY	Upregulation of mdm-2 expression in Meth A_tumor cells tolerating wild-type p53 .
8417333	0	p53	42,45	mdm-2	4,9	p53	mdm-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	suppression|compound|START_ENTITY overcome|dobj|suppression overcome|nsubj|oncogene oncogene|amod|END_ENTITY	The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth .
8529093	0	p53	45,48	mdm-2	73,78	p53	mdm-2	7157	4193	Gene	Gene	suppressor|compound|START_ENTITY Regulation|nmod|suppressor Regulation|nmod|oncogene oncogene|amod|END_ENTITY	Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene .
8649767	0	p53	30,33	mdm-2	43,48	p53	mdm-2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	proportion|nmod|START_ENTITY Analysis|nmod|proportion bound|nsubj|Analysis bound|xcomp|END_ENTITY	Analysis of the proportion of p53 bound to mdm-2 in cells with defined growth characteristics .
8747596	0	p53	33,36	mdm-2	98,103	p53	mdm-2	7157	4193	Gene	Gene	detection|nmod|START_ENTITY associated|nsubjpass|detection associated|nmod|overexpression overexpression|amod|END_ENTITY	Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression .
8747596	0	p53	60,63	mdm-2	98,103	p53	mdm-2	7157	4193	Gene	Gene	mutations|compound|START_ENTITY melanomas|nmod|mutations p53|nmod|melanomas detection|nmod|p53 associated|nsubjpass|detection associated|nmod|overexpression overexpression|amod|END_ENTITY	Immunohistochemical detection of p53 in melanomas with rare p53 gene mutations is associated with mdm-2 overexpression .
8957072	0	p53	10,13	mdm-2	48,53	p53	mdm-2	7157	4193	Gene	Gene	protein|compound|START_ENTITY unable|nsubj|protein unable|xcomp|activate activate|dobj|gene gene|amod|END_ENTITY	Wild-type p53 protein is unable to activate the mdm-2 gene during F9 cell differentiation .
9150392	0	p53	38,41	mdm-2	106,111	p53	mdm-2	301300(Tax:10116)	314856(Tax:10116)	Gene	Gene	levels|nmod|START_ENTITY Tolerance|nmod|levels transformed|nsubj|Tolerance transformed|xcomp|dependent dependent|advcl|END_ENTITY	Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2 .
9291432	0	p53	53,56	mdm-2	22,27	p53	mdm-2	7157	4193	Gene	Gene	status|compound|START_ENTITY expression|nmod|status expression|nmod|END_ENTITY	Altered expression of mdm-2 and its association with p53 protein status , tumor-cell-proliferation rate and prognosis in cervical neoplasia .
9688185	0	p53	53,56	mdm-2	58,63	p53	mdm-2	7157	4193	Gene	Gene	E2F-1|appos|START_ENTITY E2F-1|amod|p21waf-1 p21waf-1|amod|END_ENTITY	Expression of the cell-cycle-related proteins E2F-1 , p53 , mdm-2 , p21waf-1 , and Ki-67 in multiple myeloma : correlation with cyclin-D1 immunoreactivity .
9790068	0	p53	120,123	mdm-2	14,19	p53	mdm-2	7157	4193	Gene	Gene	expression|compound|START_ENTITY study|nmod|expression Expression|dep|study Expression|nmod|protein protein|amod|END_ENTITY	Expression of mdm-2 protein in neoplastic , preneoplastic , and normal bronchial mucosa specimens : comparative study with p53 expression .
10023338	0	p53	97,100	mdm2	34,38	p53	mdm2	7157	4193	Gene	Gene	protein|compound|START_ENTITY correlation|nmod|protein expression|dep|correlation expression|nmod|END_ENTITY	Immunohistochemical expression of mdm2 and p21WAF1 in invasive_cervical_cancer : correlation with p53 protein and high risk HPV infection .
10074928	0	p53	90,93	mdm2	36,40	p53	mdm2	7157	4193	Gene	Gene	protein|compound|START_ENTITY correlates|nmod|protein correlates|nsubj|transcripts transcripts|amod|END_ENTITY	Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells .
10432310	0	p53	63,66	mdm2	114,118	p53	mdm2	7157	4193	Gene	Gene	START_ENTITY|acl:relcl|disrupt disrupt|dobj|protein protein|amod|binding binding|nmod|END_ENTITY	Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 -LRB- mouse_double_minute_2 -RRB- protein are modified in human cancers .
10815906	0	p53	94,97	mdm2	0,4	p53	mdm2	7157	4193	Gene	Gene	overexpression|compound|START_ENTITY comparison|nmod|overexpression expression|dep|comparison expression|amod|END_ENTITY	mdm2 expression as a prognostic indicator in clear_cell_renal_cell_carcinoma : comparison with p53 overexpression and clinicopathological parameters .
11033015	0	p53	113,116	mdm2	151,155	p53	mdm2	7157	4193	Gene	Gene	residues|nmod|START_ENTITY residues|acl|involved involved|nmod|interactions interactions|nmod|protein protein|amod|END_ENTITY	Critical residues of epitopes recognized by several anti-p53 monoclonal antibodies correspond to key residues of p53 involved in interactions with the mdm2 protein .
11057904	0	p53	27,30	mdm2	62,66	p53	mdm2	7157	4193	Gene	Gene	effects|nmod|START_ENTITY effects|dep|activation activation|nmod|END_ENTITY	Opposing effects of Ras on p53 : transcriptional activation of mdm2 and induction of p19ARF .
11173581	0	p53	54,57	mdm2	21,25	p53	mdm2	7157	4193	Gene	Gene	Markers|appos|START_ENTITY Versus|dobj|Markers Versus|nsubj|Proliferative Proliferative|appos|MIB1 MIB1|dep|END_ENTITY	Proliferative -LRB- MIB1 , mdm2 -RRB- Versus Anti-Proliferative -LRB- p53 -RRB- Markers in Head_and_Neck_Cancer .
11240753	0	p53	47,50	mdm2	128,132	p53	mdm2	7157	4193	Gene	Gene	gene|compound|START_ENTITY analysis|nmod|gene analysis|dep|correlation correlation|nmod|END_ENTITY	Immunohistochemical and mutational analysis of p53 tumor suppressor gene in gestational_trophoblastic_disease : correlation with mdm2 , proliferation index , and clinicopathologic parameters .
11240767	0	p53	31,34	mdm2	36,40	p53	mdm2	7157	4193	Gene	Gene	significance|nmod|START_ENTITY significance|amod|c-erbB-2 c-erbB-2|amod|END_ENTITY	The prognostic significance of p53 , mdm2 , c-erbB-2 , cathepsin_D , and thrombocytosis in stage_IB_cervical_cancer treated by primary radical hysterectomy .
11397792	0	p53	52,55	mdm2	6,10	p53	mdm2	7157	4193	Gene	Gene	mono-ubiquitination|nmod|START_ENTITY mediates|dobj|mono-ubiquitination mediates|nsubj|END_ENTITY	Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization .
12138177	0	p53	51,54	mdm2	34,38	p53	mdm2	7157	4193	Gene	Gene	oncogene|nmod|START_ENTITY oncogene|amod|END_ENTITY	Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes .
12509446	0	p53	35,38	mdm2	0,4	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY critical|nmod|inhibition critical|nsubj|END_ENTITY	mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation .
14555661	0	p53	10,13	mdm2	121,125	p53	mdm2	7157	4193	Gene	Gene	modification|compound|START_ENTITY required|nsubj|modification required|nmod|amplification amplification|amod|END_ENTITY	Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification .
14555661	0	p53	69,72	mdm2	121,125	p53	mdm2	7157	4193	Gene	Gene	inactivation|compound|START_ENTITY required|nmod|inactivation required|nmod|amplification amplification|amod|END_ENTITY	Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification .
14695178	0	p53	78,81	mdm2	38,42	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	targets|nummod|START_ENTITY deletion|nmod|targets Switching|nmod|deletion Switching|dobj|mechanisms mechanisms|nmod|death death|nmod|END_ENTITY	Switching mechanisms of cell death in mdm2 - and mdm4-null mice by deletion of p53 downstream targets .
15361844	0	p53	12,15	mdm2	70,74	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	389|compound|START_ENTITY Mutation|nmod|389 rescue|nsubj|Mutation rescue|dobj|embryonic_lethality embryonic_lethality|nmod|mice mice|amod|END_ENTITY	Mutation at p53 serine 389 does not rescue the embryonic_lethality in mdm2 or mdm4 null mice .
16470212	0	p53	124,127	mdm2	81,85	p53	mdm2	7157	4193	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2 - and E1b-55kD-mediated degradation of p53 .
16470212	0	p53	20,23	mdm2	81,85	p53	mdm2	7157	4193	Gene	Gene	transgene|compound|START_ENTITY Modification|nmod|transgene prevents|nsubj|Modification prevents|dobj|degradation degradation|amod|END_ENTITY	Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2 - and E1b-55kD-mediated degradation of p53 .
16696089	1	p53	87,90	mdm2	108,112	p53	mdm2	7157	4193	Gene	Gene	study|nmod|START_ENTITY induced|nsubj|study induced|xcomp|END_ENTITY	Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1 .
17395400	0	p53	69,72	mdm2	74,78	p53	mdm2	7157	4193	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
17989425	0	p53	53,56	mdm2	66,70	p53	mdm2	7157	4193	Gene	Gene	ubiquitination|nmod|START_ENTITY measuring|dobj|ubiquitination measuring|nmod|END_ENTITY	A high-throughput screen measuring ubiquitination of p53 by human mdm2 .
18852133	0	p53	38,41	mdm2	77,81	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	inducer|compound|START_ENTITY apoptosis|nmod|inducer apoptosis|nmod|down-regulation down-regulation|nmod|END_ENTITY	Gambogic_acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells .
22787160	0	p53	70,73	mdm2	41,45	p53	mdm2	7157	4193	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Transcription factor NFAT1 activates the mdm2 oncogene independent of p53 .
23416275	0	p53	14,17	mdm2	44,48	p53	mdm2	7157	4193	Gene	Gene	C-terminal|compound|START_ENTITY Modulation|nmod|C-terminal acetylation|nsubj|Modulation acetylation|nmod|p14ARF p14ARF|compound|END_ENTITY	Modulation of p53 C-terminal acetylation by mdm2 , p14ARF , and cytoplasmic SirT2 .
25746004	0	p53	28,31	mdm2	93,97	p53	mdm2	30590(Tax:7955)	30637(Tax:7955)	Gene	Gene	signaling|nmod|START_ENTITY Tumor-specific|acl|signaling mimicked|nsubjpass|Tumor-specific mimicked|nmod|inactivation inactivation|dep|insights insights|nmod|END_ENTITY	Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish : insights from mdm2 and mdm4 mutant zebrafish .
26416444	0	p53	83,86	mdm2	11,15	p53	mdm2	7157	4193	Gene	Gene	genes|compound|START_ENTITY elongation|nmod|genes cells|nmod|elongation cells|amod|END_ENTITY	Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death .
26854347	0	p53	58,61	mdm2	119,123	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|advcl|increasing increasing|iobj|expression expression|appos|END_ENTITY	The viral non-structural protein 1 alpha -LRB- Nsp1a -RRB- inhibits p53 apoptosis activity by increasing murine_double_minute_2 -LRB- mdm2 -RRB- expression in porcine_reproductive_and_respiratory_syndrome virus -LRB- PRRSV -RRB- early-infected cells .
7551299	0	p53	102,105	mdm2	0,4	p53	mdm2	7157	4193	Gene	Gene	protein|compound|START_ENTITY amplification|nmod|protein amplification|amod|END_ENTITY	mdm2 gene amplification and overexpression in non-small_cell_lung_carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations .
7551299	0	p53	132,135	mdm2	0,4	p53	mdm2	7157	4193	Gene	Gene	mutations|compound|START_ENTITY absence|nmod|mutations amplification|nmod|absence amplification|amod|END_ENTITY	mdm2 gene amplification and overexpression in non-small_cell_lung_carcinomas with accumulation of the p53 protein in the absence of p53 gene mutations .
7663443	0	p53	141,144	mdm2	32,36	p53	mdm2	7157	4193	Gene	Gene	not|nmod|START_ENTITY carbon_tetrachloride|dep|not increases|xcomp|carbon_tetrachloride increases|advmod|markedly markedly|nmod:npmod|END_ENTITY	Expression of the protooncogene mdm2 markedly increases in response to carbon_tetrachloride but not after partial hepatectomy in contrast to p53 .
7753547	0	p53	31,34	mdm2	71,75	p53	mdm2	7157	4193	Gene	Gene	Oligomerisation|nmod|START_ENTITY contributes|nsubj|Oligomerisation contributes|nmod|interaction interaction|nmod|END_ENTITY	Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6 .
7958853	0	p53	33,36	mdm2	14,18	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of mdm2 expression by p53 : alternative promoters produce transcripts with nonidentical translation potential .
8247544	0	p53	10,13	mdm2	95,99	p53	mdm2	7157	4193	Gene	Gene	mediate|nsubj|START_ENTITY mediate|nmod|gene gene|amod|END_ENTITY	Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene .
8280379	0	p53	15,18	mdm2	97,101	p53	mdm2	7157	4193	Gene	Gene	mutations|compound|START_ENTITY Correlation|nmod|mutations Correlation|nmod|amplification amplification|amod|END_ENTITY	Correlation of p53 mutations with epidermal_growth_factor_receptor overexpression and absence of mdm2 amplification in human esophageal_carcinomas .
8440237	0	p53	40,43	mdm2	0,4	p53	mdm2	7157	4193	Gene	Gene	activity|compound|START_ENTITY induced|nmod|activity induced|nsubjpass|expression expression|amod|END_ENTITY	mdm2 expression is induced by wild type p53 activity .
8705862	0	p53	52,55	mdm2	22,26	p53	mdm2	7157	4193	Gene	Gene	sequences|nummod|START_ENTITY loss|nmod|sequences transcripts|nmod|loss transcripts|amod|END_ENTITY	Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences : transforming ability and frequent detection in human cancer .
9029163	0	p53	0,3	mdm2	28,32	p53	mdm2	301300(Tax:10116)	314856(Tax:10116)	Gene	Gene	mutation|compound|START_ENTITY mutation|nmod|amplification amplification|amod|END_ENTITY	p53 mutation and absence of mdm2 amplification and Ki-ras mutation in 4-hydroxyamino_quinoline_1-oxide induced transplantable osteosarcomas in rats .
9216675	1	p53	82,85	mdm2	103,107	p53	mdm2	7157	4193	Gene	Gene	study|nmod|START_ENTITY induced|nsubj|study induced|xcomp|END_ENTITY	Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1 .
9270029	0	p53	109,112	mdm2	29,33	p53	mdm2	7157	4193	Gene	Gene	protein|compound|START_ENTITY containing|dobj|protein enhancement|acl|containing enhancement|nmod|expression expression|amod|END_ENTITY	Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein .
9380404	0	p53	4,7	mdm2	16,20	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	targets|nsubj|START_ENTITY targets|ccomp|required required|nsubjpass|END_ENTITY	The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo .
9438391	0	p53	42,45	mdm2	0,4	p53	mdm2	7157	4193	Gene	Gene	response|compound|START_ENTITY mediators|nmod|response END_ENTITY|appos|mediators	mdm2 and bax , downstream mediators of the p53 response , are degraded by the ubiquitin-proteasome pathway .
9486848	0	p53	57,60	mdm2	44,48	p53	mdm2	7157	4193	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of transcriptional activation of mdm2 gene by p53 in response to UV radiation .
9528859	0	p53	0,3	mdm2	60,64	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|region region|nmod|gene gene|amod|END_ENTITY	p53 binds to a constitutively nucleosome free region of the mdm2 gene .
9645455	0	p53	72,75	mdm2	22,26	p53	mdm2	7157	4193	Gene	Gene	gene|compound|START_ENTITY aberration|nmod|gene related|nmod|aberration related|nsubjpass|expression expression|nmod|gene gene|amod|END_ENTITY	The expression of the mdm2 gene may be related to the aberration of the p53 gene in human hepatocellular_carcinoma .
9649502	0	p53	74,77	mdm2	34,38	p53	mdm2	22060(Tax:10090)	17246(Tax:10090)	Gene	Gene	function|compound|START_ENTITY induces|dobj|function induces|nsubj|Suppression Suppression|nmod|loop loop|amod|END_ENTITY	Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function .
9681831	0	p53	87,90	mdm2	103,107	p53	mdm2	7157	4193	Gene	Gene	function|compound|START_ENTITY regulation|nmod|function dependent|nmod|regulation dependent|nmod|END_ENTITY	The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2 .
12036937	0	p53	32,35	mdmx	0,4	p53	mdmx	22060(Tax:10090)	17248(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY regulator|nmod|activity regulator|nsubj|END_ENTITY	mdmx is a negative regulator of p53 activity in vivo .
24632606	0	p53	8,11	miR-148b	26,34	p53	miR-148b	7157	442892	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal_cancer .
23670238	0	p53	9,12	miR-150	0,7	p53	miR-150	7157	406942	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	miR-150 , p53 protein and relevant miRNAs consist of a regulatory network in NSCLC_tumorigenesis .
26553132	0	p53	17,20	miR-23a	0,7	p53	miR-23a	7157	407010	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	miR-23a binds to p53 and enhances its association with miR-128 promoter .
23796712	0	p53	0,3	miR-34a	36,43	p53	miR-34a	7157	407040	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|END_ENTITY	p53 regulates glucose metabolism by miR-34a .
20542001	0	p53	40,43	miR-504	56,63	p53	miR-504	7157	574507	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of tumor suppressor p53 by microRNA miR-504 .
8956998	0	p53	10,13	microtubule-associated_protein	55,85	p53	microtubule-associated protein	7157	51115	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Wild-type p53 negatively regulates the expression of a microtubule-associated_protein .
9792667	0	p53	33,36	mot-2	40,45	p53	mot-2	22060(Tax:10090)	15526(Tax:10090)	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of tumor suppressor p53 by mot-2 , a hsp70 family member .
15144402	0	p53	19,22	mucin	12,17	p53	mucin	7157	4583	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Analysis of mucin , p53 protein and Ki-67 expressions in gastric differentiated-type intramucosal neoplastic_lesions obtained from endoscopic mucosal resection samples : a proposal for a new classification of intramucosal neoplastic_lesions based on nuclear atypia .
7949467	0	p53	74,77	multidrug_resistance	29,49	p53	multidrug resistance	7157	5243	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Transactivation of the human multidrug_resistance -LRB- MDR1 -RRB- gene promoter by p53 mutants .
11326661	0	p53	40,43	nm23	45,49	p53	nm23	7157	4830	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	Immunohistochemical examinations -LRB- Ki67 , p53 , nm23 -RRB- and DNA cytophotometry in bladder_cancer .
19026164	0	p53	137,140	nm23-H1	19,26	p53	nm23-H1	7157	4830	Gene	Gene	raising|dobj|START_ENTITY due|advcl|raising oxidative|xcomp|due provides|advcl|oxidative provides|nsubj|Over-expression Over-expression|nmod|cells cells|amod|END_ENTITY	Over-expression of nm23-H1 in HeLa cells provides cells with higher resistance to oxidative stress possibly due to raising intracellular p53 and GPX1 .
22405968	0	p53	0,3	osteocalcin	47,58	p53	osteocalcin	301300(Tax:10116)	81613(Tax:10116)	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	p53 and MDM2 are involved in the regulation of osteocalcin gene expression .
27022290	0	p53	0,3	p125	31,35	p53	p125	7157	11196	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|nmod|END_ENTITY	p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast_cancer .
10797439	0	p53	32,35	p14	48,51	p53	p14	7157	1029	Gene	Gene	INK4A|dep|START_ENTITY Investigation|nmod|INK4A /|nsubj|Investigation /|dobj|END_ENTITY	Investigation of germline PTEN , p53 , p16 -LRB- INK4A -RRB- / p14 -LRB- ARF -RRB- , and CDK4 alterations in familial_glioma .
10801444	0	p53	68,71	p14	56,59	p53	p14	7157	11102	Gene	Gene	stabilization|compound|START_ENTITY domains|nmod|stabilization domains|nmod|END_ENTITY	Contribution of two independent MDM2-binding domains in p14 -LRB- ARF -RRB- to p53 stabilization .
11507034	0	p53	89,92	p14	0,3	p53	p14	7157	1029	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	p14 -LRB- ARF -RRB- modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53 .
12082630	0	p53	55,58	p14	38,41	p53	p14	7157	1029	Gene	Gene	apoptosis|compound|START_ENTITY induces|dobj|apoptosis induces|nsubj|overexpression overexpression|nmod|END_ENTITY	Adenovirus-mediated overexpression of p14 -LRB- ARF -RRB- induces p53 and Bax-independent apoptosis .
12082636	0	p53	69,72	p14	6,9	p53	p14	7157	1029	Gene	Gene	depends|nmod|START_ENTITY cell|acl:relcl|depends END_ENTITY|dep|cell	Human p14 -LRB- ARF -RRB- - mediated cell cycle arrest strictly depends on intact p53 signaling pathways .
15073599	0	p53	71,74	p14	15,18	p53	p14	7157	11102	Gene	Gene	expression|compound|START_ENTITY Methylation|nmod|expression Methylation|nmod|gene gene|amod|END_ENTITY	Methylation of p14 -LRB- ARF -RRB- gene in meningiomas and its correlation to the p53 expression and mutation .
16162359	0	p53	4,7	p14	112,115	p53	p14	7157	11102	Gene	Gene	expression|compound|START_ENTITY expression|dep|association association|nmod|expression expression|amod|END_ENTITY	Low p53 expression of acute_myelocytic_leukemia cells with t -LRB- 8 ; 21 -RRB- chromosome_abnormality : association with low p14 -LRB- ARF -RRB- expression .
17395400	0	p53	69,72	p14	59,62	p53	p14	7157	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
22354970	0	p53	30,33	p14	0,3	p53	p14	7157	11102	Gene	Gene	apoptosis|nmod|START_ENTITY END_ENTITY|dep|apoptosis	p14 -LRB- ARF -RRB- - induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins .
22621932	0	p53	125,128	p14	85,88	p53	p14	7157	11102	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	Transforming_growth_factor_b1 -LRB- TGF-b1 -RRB- suppresses growth of B-cell_lymphoma cells by p14 -LRB- ARF -RRB- - dependent regulation of mutant p53 .
9724636	0	p53	111,114	p14	53,56	p53	p14	7157	1029	Gene	Gene	loop|nmod|START_ENTITY participates|nmod|loop participates|nsubj|product product|appos|END_ENTITY	The alternative product from the human CDKN2A locus , p14 -LRB- ARF -RRB- , participates in a regulatory feedback loop with p53 and MDM2 .
11526482	0	p53	59,62	p14ARF	21,27	p53	p14ARF	7157	1029	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo .
10071127	0	p53	19,22	p16	29,32	p53	p16	7157	1029	Gene	Gene	p15|compound|START_ENTITY p15|dep|END_ENTITY	Alterations of the p53 , p21 , p16 , p15 and RAS genes in childhood_T-cell_acute_lymphoblastic_leukemia .
10226946	0	p53	73,76	p16	63,66	p53	p16	7157	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
10797439	0	p53	32,35	p16	37,40	p53	p16	7157	1029	Gene	Gene	INK4A|dep|START_ENTITY INK4A|amod|END_ENTITY	Investigation of germline PTEN , p53 , p16 -LRB- INK4A -RRB- / p14 -LRB- ARF -RRB- , and CDK4 alterations in familial_glioma .
10922393	0	p53	46,49	p16	20,23	p53	p16	7157	1029	Gene	Gene	families|nummod|START_ENTITY alterations|nmod|families alterations|nsubj|Absence Absence|nmod|END_ENTITY	Absence of germline p16 -LRB- INK4a -RRB- alterations in p53 wild type Li-Fraumeni_syndrome families .
10986054	0	p53	66,69	p16	28,31	p53	p16	7157	1029	Gene	Gene	mutation|compound|START_ENTITY hypermethylation|appos|mutation INK4a|dep|hypermethylation INK4a|amod|END_ENTITY	Differential frequencies of p16 -LRB- INK4a -RRB- promoter hypermethylation , p53 mutation , and K-ras mutation in exfoliative material mark the development of lung_cancer in symptomatic chronic smokers .
11115575	0	p53	48,51	p16	53,56	p53	p16	7157	1029	Gene	Gene	K-ras|nummod|START_ENTITY K-ras|nummod|END_ENTITY	Characterization of the mutations of the K-ras , p53 , p16 , and SMAD4 genes in 15 human pancreatic_cancer cell lines .
11205312	0	p53	38,41	p16	58,61	p53	p16	7157	1029	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|-1 -1|nummod|END_ENTITY	Immunohistochemical expression of the p53 , p21/Waf -1 , Rb , p16 and Ki67 proteins in multiple_myeloma .
11733961	0	p53	105,108	p16	26,29	p53	p16	7157	1029	Gene	Gene	mutations|compound|START_ENTITY lacking|dobj|mutations frequent|xcomp|lacking frequent|nsubj|Loss Loss|nmod|expression expression|nmod|gene gene|amod|END_ENTITY	Loss of expression of the p16 tumor suppressor gene is more frequent in advanced ovarian_cancers lacking p53 mutations .
11756558	0	p53	43,46	p16	19,22	p53	p16	22060(Tax:10090)	12578(Tax:10090)	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Obligate roles for p16 -LRB- Ink4a -RRB- and p19 -LRB- Arf -RRB- - p53 in the suppression of murine pancreatic neoplasia .
11776846	0	p53	57,60	p16	21,24	p53	p16	7157	1029	Gene	Gene	cells|compound|START_ENTITY growth|nmod|cells gene|nmod|growth gene|amod|END_ENTITY	-LSB- Effect of exogenous p16 gene on the growth of wild-type p53 human lung_adenocarcinoma cells -RSB- .
11777345	0	p53	23,26	p16	29,32	p53	p16	7157	1029	Gene	Gene	-|compound|START_ENTITY -|appos|INK4a INK4a|amod|END_ENTITY	Expression profiles of p53 - , p16 -LRB- INK4a -RRB- - , and telomere-regulating genes in replicative senescent primary human , mouse , and chicken fibroblast cells .
11866886	0	p53	6,9	p16	1,4	p53	p16	7157	1029	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	-LSB- p16 , p53 and c-erbB-2 gene expression in bladder_carcinoma -RSB- .
12378511	0	p53	31,34	p16	36,39	p53	p16	7157	1029	Gene	Gene	p27|compound|START_ENTITY p27|dep|END_ENTITY	Expression of G1-S modulators -LRB- p53 , p16 , p27 , cyclin_D1 , Rb -RRB- and Smad4/Dpc4 in intrahepatic_cholangiocarcinoma .
14556194	0	p53	64,67	p16	39,42	p53	p16	22060(Tax:10090)	12578(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	-LSB- Research on expression and control of p16 and p21 by wild-type p53 gene in two lung_adenocarcinoma cell lines -RSB- .
16489012	0	p53	40,43	p16	69,72	p53	p16	7157	1029	Gene	Gene	knockdown|compound|START_ENTITY V12|appos|knockdown V12|appos|bypass bypass|amod|END_ENTITY	Multiple oncogenic changes -LRB- K-RAS -LRB- V12 -RRB- , p53 knockdown , mutant EGFRs , p16 bypass , telomerase -RRB- are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells .
16948516	0	p53	68,71	p16	63,66	p53	p16	7157	1029	Gene	Gene	pRb|dep|START_ENTITY pRb|compound|END_ENTITY	Upper aerodigestive tract squamous dysplasia : correlation with p16 , p53 , pRb , and Ki-67 expression .
16998811	0	p53	55,58	p16	60,63	p53	p16	7157	1029	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17060721	0	p53	19,22	p16	24,27	p53	p16	7157	1029	Gene	Gene	esophageal_squamous_cell_carcinoma|compound|START_ENTITY esophageal_squamous_cell_carcinoma|dep|END_ENTITY	-LSB- The expression of p53 , p16 , cyclin_D1 in esophageal_squamous_cell_carcinoma and esophageal_dysplasia -RSB- .
17152048	0	p53	41,44	p16	14,17	p53	p16	7157	1029	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Comparison of p16 -LRB- INK4a -RRB- expression with p53 alterations in head_and_neck_cancer by tissue microarray analysis .
17395400	0	p53	69,72	p16	64,67	p53	p16	7157	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
18021213	0	p53	96,99	p16	14,17	p53	p16	7157	1029	Gene	Gene	activity|compound|START_ENTITY related|nmod|activity related|nsubjpass|Expression Expression|nmod|infection infection|amod|END_ENTITY	Expression of p16 and cervical infection with high-risk human_papillomavirus are not related to p53 activity in cervical_intraepithelial_neoplasia .
19148359	0	p53	1,4	p16	6,9	p53	p16	7157	1029	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	-LSB- p53 , p16 E COX-2 expression in esophageal_squamous_cell_carcinoma and histopathological association -RSB- .
19575869	0	p53	31,34	p16	36,39	p53	p16	7157	1029	Gene	Gene	protein|dep|START_ENTITY protein|dep|END_ENTITY	-LSB- Abnormal expression of c-myc , p53 , p16 protein and GNAS1 gene mutation in fibrous_dysplasia -RSB- .
20416157	0	p53	27,30	p16	22,25	p53	p16	7157	1029	Gene	Gene	transfection|compound|START_ENTITY END_ENTITY|appos|transfection	-LSB- Inhibitory effect of p16 , p53 transfection on leukemic cell lines K562 and HL-60 -RSB- .
24178677	0	p53	48,51	p16	43,46	p53	p16	7157	1029	Gene	Gene	Proteins|nummod|START_ENTITY Proteins|nummod|END_ENTITY	Expression of Cell Cycle-Related Proteins , p16 , p53 and p63 as Important Prognostic Markers in Gallbladder_Adenocarcinoma .
25201325	0	p53	58,61	p16	78,81	p53	p16	7157	1029	Gene	Gene	expression|compound|START_ENTITY expression|appos|overexpression overexpression|amod|END_ENTITY	Human_papillomavirus infection in Bowen_disease : Negative p53 expression , not p16 -LRB- INK -RRB- _ -LRB- 4a -RRB- overexpression , is correlated with human_papillomavirus-associated Bowen_disease .
25857071	0	p53	18,21	p16	23,26	p53	p16	7157	1029	Gene	Gene	DPC4|compound|START_ENTITY DPC4|dep|END_ENTITY	-LSB- Oncogene -LRB- K-ras , p53 , p16 , DPC4 , hTERTmRNA -RRB- -RSB- .
25916534	0	p53	43,46	p16	38,41	p53	p16	7157	1029	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	-LSB- Clinical features and expressions of p16 , p53 protein of human_papillomavirus-related tonsillar_carcinoma -RSB- .
25916534	0	p53	43,46	p16	38,41	p53	p16	7157	1029	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	-LSB- Clinical features and expressions of p16 , p53 protein of human_papillomavirus-related tonsillar_carcinoma -RSB- .
26398519	0	p53	95,98	p16	90,93	p53	p16	7157	1029	Gene	Gene	Ki67|dep|START_ENTITY Ki67|dep|END_ENTITY	In situ carcinoma developed over_oral_lichen_planus : a case report with analysis of BUB3 , p16 , p53 , Ki67 and SOX4 expression .
7473071	0	p53	55,58	p16	21,24	p53	p16	7157	1029	Gene	Gene	protein|compound|START_ENTITY location|nmod|protein location|nmod|protein protein|amod|END_ENTITY	Abnormal location of p16 protein and overexpression of p53 protein in human radiation-induced skin_cancer .
8674005	0	p53	31,34	p16	36,39	p53	p16	7157	1029	Gene	Gene	Alterations|appos|START_ENTITY Alterations|appos|END_ENTITY	Alterations of retinoblastoma , p53 , p16 -LRB- CDKN2 -RRB- , and p15 genes in human astrocytomas .
9047388	0	p53	84,87	p16	19,22	p53	p16	7157	1029	Gene	Gene	frequency|nmod|START_ENTITY Alterations|dep|frequency Alterations|nmod|gene gene|amod|END_ENTITY	Alterations of the p16 gene in head_and_neck_cancer : frequency and association with p53 , PRAD-1 and HPV .
9210874	0	p53	17,20	p16	65,68	p53	p16	7157	1029	Gene	Gene	mutations|compound|START_ENTITY Determination|nmod|mutations Determination|nmod|expression expression|amod|END_ENTITY	Determination of p53 mutations , EGFR overexpression , and loss of p16 expression in pediatric_glioblastomas .
9490270	0	p53	51,54	p16	36,39	p53	p16	7157	1029	Gene	Gene	9p21|appos|START_ENTITY 9p21|appos|END_ENTITY	Allelic deletion at chromosome 9p21 -LRB- p16 -RRB- and 17p13 -LRB- p53 -RRB- in microdissected sporadic dysplastic_nevus .
14981901	0	p53	138,141	p16INK4A	45,53	p53	p16INK4A	7157	1029	Gene	Gene	status|compound|START_ENTITY infrequent|nmod|status infrequent|nsubj|Mutations Mutations|nmod|cycle cycle|dep|END_ENTITY	Mutations of the cell cycle regulatory genes p16INK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal_squamous_cell_carcinomas .
19851199	0	p53	124,127	p16INK4A	114,122	p53	p16INK4A	7157	1029	Gene	Gene	receptors|dep|START_ENTITY receptors|compound|END_ENTITY	Atypical_leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A , p53 , Ki-67 , estrogen receptors , and progesterone receptors .
21526487	0	p53	86,89	p16INK4A	62,70	p53	p16INK4A	7157	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Effect of human_papillomavirus on cell cycle-related proteins p16INK4A , p21waf1/cip1 , p53 and cyclin_D1 in sinonasal inverted_papilloma and laryngeal_carcinoma .
24021343	0	p53	10,13	p16INK4A	0,8	p53	p16INK4A	7157	1029	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	p16INK4A , p53 , EGFR expression and KRAS mutation status in squamous_cell_cancers of the anus : correlation with outcomes following chemo-radiotherapy .
10465111	0	p53	34,37	p16INK4a	39,47	p53	p16INK4a	7157	1029	Gene	Gene	N-ras|nummod|START_ENTITY N-ras|nummod|END_ENTITY	Mutational analysis of the N-ras , p53 , p16INK4a , CDK4 , and MC1R genes in human congenital_melanocytic_naevi .
11172613	0	p53	30,33	p16INK4a	35,43	p53	p16INK4a	7157	1029	Gene	Gene	p14ARF|dep|START_ENTITY p14ARF|dep|END_ENTITY	Mutational analysis of N-ras , p53 , p16INK4a , p14ARF and CDK4 genes in primary human malignant mesotheliomas .
11753042	0	p53	95,98	p16INK4a	0,8	p53	p16INK4a	7157	1029	Gene	Gene	p16INK4a|appos|START_ENTITY analysis|nmod|p16INK4a marker|dep|analysis marker|nsubj|END_ENTITY	p16INK4a is a prognostic marker in resected_ductal_pancreatic_cancer : an analysis of p16INK4a , p53 , MDM2 , an Rb .
16243918	0	p53	130,133	p16INK4a	16,24	p53	p16INK4a	7157	1029	Gene	Gene	role|nmod|START_ENTITY Contribution|dep|role Contribution|nmod|pathways pathways|amod|END_ENTITY	Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells : permissive role of p53 .
17079452	0	p53	19,22	p16INK4a	0,8	p53	p16INK4a	7157	1029	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	p16INK4a modulates p53 in primary human mammary epithelial cells .
19240179	0	p53	0,3	p16INK4a	54,62	p53	p16INK4a	22060(Tax:10090)	12578(Tax:10090)	Gene	Gene	Deficiency|compound|START_ENTITY leads|nsubj|Deficiency leads|xcomp|compensatory compensatory|dobj|up-regulation up-regulation|nmod|END_ENTITY	p53 Deficiency leads to compensatory up-regulation of p16INK4a .
19667129	0	p53	62,65	p16Ink4a	29,37	p53	p16Ink4a	22060(Tax:10090)	12578(Tax:10090)	Gene	Gene	reveals|nmod|START_ENTITY reveals|nsubj|Real-time Real-time|nmod|imaging imaging|nmod|END_ENTITY	Real-time in vivo imaging of p16Ink4a reveals cross talk with p53 .
23474228	0	p53	150,153	p16ink4a	84,92	p53	p16ink4a	7157	1029	Gene	Gene	express|dobj|START_ENTITY express|nsubj|pathways pathways|nmod|penile_carcinogenesis penile_carcinogenesis|dep|END_ENTITY	Two major pathways of penile_carcinogenesis : HPV-induced penile_cancers overexpress p16ink4a , HPV-negative_cancers associated with dermatoses express p53 , but lack p16ink4a overexpression .
15680327	0	p53	55,58	p18	39,42	p53	p18	22060(Tax:10090)	12580(Tax:10090)	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR .
7913577	0	p53	0,3	p185	34,38	p53	p185	7157	8661	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	p53 protein and c-erbB-2 protein -LRB- p185 -RRB- expression in endometrial_adenocarcinoma of endometrioid type .
11057904	0	p53	27,30	p19ARF	84,90	p53	p19ARF	7157	1029	Gene	Gene	effects|nmod|START_ENTITY effects|dep|activation activation|nmod|END_ENTITY	Opposing effects of Ras on p53 : transcriptional activation of mdm2 and induction of p19ARF .
10070887	0	p53	89,92	p21	0,3	p53	p21	7157	1026	Gene	Gene	proliferation|compound|START_ENTITY relationship|nmod|proliferation malignant_melanoma|dep|relationship malignant_melanoma|amod|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- expression in stage I cutaneous malignant_melanoma : its relationship with p53 , cell proliferation and survival .
10071127	0	p53	19,22	p21	24,27	p53	p21	7157	644914	Gene	Gene	p15|compound|START_ENTITY p15|dep|END_ENTITY	Alterations of the p53 , p21 , p16 , p15 and RAS genes in childhood_T-cell_acute_lymphoblastic_leukemia .
10072848	0	p53	65,68	p21	70,73	p53	p21	7157	644914	Gene	Gene	p185|compound|START_ENTITY p185|dep|END_ENTITY	-LSB- The correlation between expression of oncogene protein products p53 , p21 , p185 and cell differentiation and prognosis in rhabdomyosarcoma -RSB- .
10347252	0	p53	122,125	p21	18,21	p53	p21	7157	1026	Gene	Gene	protein|amod|START_ENTITY lacking|dobj|protein induced|xcomp|lacking arrest|acl|induced decreases|dobj|arrest decreases|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of p21 -LRB- waf1 -RRB- decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein .
10407180	0	p53	14,17	p21	39,42	p53	p21	301300(Tax:10116)	24525(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of p53 and its target genes p21 -LRB- WAF1/Cip1 -RRB- and PAG608/Wig -1 in ischemic preconditioning .
10453961	0	p53	64,67	p21	14,17	p53	p21	7157	644914	Gene	Gene	profile|compound|START_ENTITY Expression|nmod|profile Expression|nmod|END_ENTITY	Expression of p21 and p27 in hepatoma cell lines with different p53 gene profile .
10466043	0	p53	0,3	p21	5,8	p53	p21	7157	1026	Gene	Gene	START_ENTITY|appos|Waf1/Cip1 Waf1/Cip1|amod|END_ENTITY	p53 , p21 -LRB- Waf1/Cip1 -RRB- and cyclin_D1 protein expression and prognosis in esophageal_cancer .
10469214	0	p53	0,3	p21	16,19	p53	p21	7157	644914	Gene	Gene	expression|compound|START_ENTITY expression|appos|expression expression|amod|END_ENTITY	p53 expression , p21 expression and the apoptotic index in endometrioid endometrial_adenocarcinoma .
10531398	0	p53	17,20	p21	68,71	p53	p21	7157	1026	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Tumor suppressor p53 but not cGMP mediates NO-induced expression of p21 -LRB- Waf1/Cip1/Sdi1 -RRB- in vascular smooth muscle cells .
10628797	0	p53	79,82	p21	0,3	p53	p21	7157	1026	Gene	Gene	mutation/expression|compound|START_ENTITY analysis|nmod|mutation/expression cases|nmod|analysis study|nmod|cases expression|dep|study expression|amod|END_ENTITY	p21 expression in colorectal_carcinomas : a study on 103 cases with analysis of p53 gene mutation/expression and clinic-pathological correlations .
10632361	0	p53	10,13	p21	25,28	p53	p21	7157	644914	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	Wild-type p53 can induce p21 and apoptosis in neuroblastoma cells but the DNA damage-induced G1 checkpoint function is attenuated .
10677604	0	p53	106,109	p21	111,114	p53	p21	301300(Tax:10116)	24525(Tax:10116)	Gene	Gene	START_ENTITY|appos|proteins proteins|amod|END_ENTITY	The effects of N-methyl-N-nitrosourea and azoxymethane on focal cerebral_infarction and the expression of p53 , p21 proteins .
10682588	0	p53	15,18	p21	27,30	p53	p21	7157	644914	Gene	Gene	products|compound|START_ENTITY products|amod|END_ENTITY	-LSB- Expression of p53 and ras p21 gene products in malignant transformed V79 cell induced by various organic components of DEPs -RSB- .
10779360	0	p53	82,85	p21	87,90	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|dep|END_ENTITY	p53-mediated DNA repair responses to UV radiation : studies of mouse cells lacking p53 , p21 , and/or gadd45 genes .
10837373	0	p53	110,113	p21	71,74	p53	p21	7157	644914	Gene	Gene	stabilization|nmod|START_ENTITY increase|nmod|stabilization increase|dobj|ubiquitination ubiquitination|nmod|protein protein|amod|END_ENTITY	Polycyclic_aromatic_hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21 .
10842159	0	p53	199,202	p21	62,65	p53	p21	301300(Tax:10116)	24525(Tax:10116)	Gene	Gene	kinase|nmod|START_ENTITY vascular|nmod|kinase vascular|nsubj|upregulates upregulates|amod|END_ENTITY	Inducible nitric_oxide synthase -LRB- iNOS -RRB- expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic_guanosine_monophosphate .
10862017	0	p53	76,79	p21	81,84	p53	p21	7157	644914	Gene	Gene	p16|compound|START_ENTITY p16|dep|END_ENTITY	Telomerase activity in head_and_neck_tumors after introduction of wild-type p53 , p21 , p16 , and E2F-1 genes by means of recombinant adenovirus .
10883667	0	p53	78,81	p21	8,11	p53	p21	7157	1026	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|expression expression|amod|END_ENTITY	Reduced p21 -LRB- WAF1/CIP1 -RRB- protein expression is predominantly related to altered p53 in hepatocellular_carcinomas .
10955790	0	p53	20,23	p21	32,35	p53	p21	7157	1026	Gene	Gene	mdm-2|compound|START_ENTITY mdm-2|nummod|END_ENTITY	Predictive value of p53 , mdm-2 , p21 , and mib-1 for chemotherapy response in advanced breast_cancer .
11059670	0	p53	98,101	p21	9,12	p53	p21	7157	644914	Gene	Gene	bearing|dobj|START_ENTITY regulation|acl|bearing regulation|amod|END_ENTITY	Aberrant p21 regulation in radioresistant primary glioblastoma_multiforme cells bearing wild-type p53 .
11097743	0	p53	80,83	p21	18,21	p53	p21	7157	1026	Gene	Gene	WiDr|nmod|START_ENTITY TNF-alpha|dep|WiDr TNF-alpha|acl|induced induced|dobj|END_ENTITY	TNF-alpha induced p21 -LRB- WAF1 -RRB- but not Bax in colon_cancer cells WiDr with mutated p53 : important role of protein stabilization .
11102889	0	p53	84,87	p21	101,104	p53	p21	7157	1026	Gene	Gene	START_ENTITY|appos|p16 p16|appos|END_ENTITY	K-ras oncogene subtype mutations are associated with survival but not expression of p53 , p16 -LRB- INK4A -RRB- , p21 -LRB- WAF-1 -RRB- , cyclin_D1 , erbB-2 and erbB-3 in resected pancreatic_ductal_adenocarcinoma .
11158294	0	p53	0,3	p21	32,35	p53	p21	7157	644914	Gene	Gene	down-regulates|compound|START_ENTITY CHK1|nsubj|down-regulates CHK1|nmod|END_ENTITY	p53 down-regulates CHK1 through p21 and the retinoblastoma protein .
11175334	0	p53	38,41	p21	71,74	p53	p21	7157	1026	Gene	Gene	phosphorylation|nmod|START_ENTITY correlates|nsubj|phosphorylation correlates|nmod|induction induction|amod|END_ENTITY	DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo .
11317955	0	p53	85,88	p21	15,18	p53	p21	7157	1026	Gene	Gene	mutation|compound|START_ENTITY relation|nmod|mutation study|nmod|relation Expression|dep|study Expression|nmod|protein protein|amod|END_ENTITY	-LSB- Expression of p21 WAF1/CIP1 protein in colorectal_cancers : study of its relation to p53 mutation and Ki67 antigen expression -RSB- .
11384995	0	p53	134,137	p21	107,110	p53	p21	7157	1026	Gene	Gene	protein|compound|START_ENTITY gene|nmod|protein gene|amod|END_ENTITY	Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by the p53 tumor suppressor protein .
11401317	0	p53	0,3	p21	76,79	p53	p21	7157	1026	Gene	Gene	missense|compound|START_ENTITY mutations|compound|missense associated|nsubjpass|mutations associated|nmod|levels levels|nmod|expression expression|amod|END_ENTITY	p53 missense but not truncation mutations are associated with low levels of p21 -LRB- CIP1/WAF1 -RRB- mRNA expression in primary human sarcomas .
11429705	0	p53	0,3	p21	59,62	p53	p21	7157	644914	Gene	Gene	mutants|compound|START_ENTITY transactivate|nsubj|mutants transactivate|dobj|promoters promoters|acl|containing containing|dobj|elements elements|amod|END_ENTITY	p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements .
11585574	0	p53	119,122	p21	96,99	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	involving|nmod|START_ENTITY involving|xcomp|END_ENTITY	Nitric_oxide inhibits the proliferation of murine microglial MG5 cells by a mechanism involving p21 but independent of p53 and cyclic_guanosine_monophosphate .
11606096	0	p53	103,106	p21	8,11	p53	p21	7157	1026	Gene	Gene	overexpression|nmod|START_ENTITY expression|dep|overexpression expression|amod|END_ENTITY	p53 and p21 expression in precancerous_lesions and carcinomas of the uterine cervix : overexpression of p53 predicts poor disease outcome .
11804280	0	p53	28,31	p21	23,26	p53	p21	7157	644914	Gene	Gene	pRb|dep|START_ENTITY pRb|compound|END_ENTITY	Cell cycle regulators -LRB- p21 , p53 , pRb -RRB- in oligodendrocytic_tumors : a study by novel tumor microarray technique .
11850848	0	p53	53,56	p21	19,22	p53	p21	7157	1026	Gene	Gene	family|compound|START_ENTITY induced|nmod|family induced|nsubjpass|p21B p21B|appos|variant variant|nmod|END_ENTITY	p21B , a variant of p21 -LRB- Waf1/Cip1 -RRB- , is induced by the p53 family .
11890931	0	p53	52,55	p21	74,77	p53	p21	7157	1026	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|expression expression|amod|END_ENTITY	SN2 DNA-alkylating agent-induced phosphorylation of p53 and activation of p21 gene expression .
12040434	4	p53	887,890	p21	892,895	p53	p21	7157	1026	Gene	Gene	+|amod|START_ENTITY +|parataxis|evolved evolved|nsubj|CLL CLL|compound|END_ENTITY	Two p53 + / p21 + CLL evolved into RS .
12080472	0	p53	19,22	p21	56,59	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY induces|nsubj|inhibition induces|dobj|transactivation transactivation|nmod|END_ENTITY	Mdm2 inhibition of p53 induces E2F1 transactivation via p21 .
12085347	0	p53	104,107	p21	24,27	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	dependent|nmod|START_ENTITY hepatocytes|acl:relcl|dependent potentiates|nmod|hepatocytes potentiates|nsubj|END_ENTITY	Cyclin kinase inhibitor p21 potentiates bile_acid-induced apoptosis in hepatocytes that is dependent on p53 .
12477050	0	p53	98,101	p21	103,106	p53	p21	7157	644914	Gene	Gene	bax|compound|START_ENTITY bax|dep|END_ENTITY	Inhibition of cell growth by NB1011 requires high thymidylate_synthase levels and correlates with p53 , p21 , bax , and GADD45 induction .
12651158	0	p53	104,107	p21	68,71	p53	p21	7157	1026	Gene	Gene	activation|nmod|START_ENTITY Waf1|nmod|activation Cip1|appos|Waf1 Cip1|amod|END_ENTITY	Prolonged progestin treatment induces the promoter of CDK inhibitor p21 Cip1 , Waf1 through activation of p53 in human breast and endometrial_tumor cells .
12706118	0	p53	7,10	p21	109,112	p53	p21	7157	1026	Gene	Gene	delay|nsubj|START_ENTITY delay|advcl|senescing senescing|advcl|reducing reducing|dobj|expression expression|amod|END_ENTITY	Mutant p53 can delay growth_arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21 -LRB- WAF1 -RRB- expression .
12824923	0	p53	101,104	p21	147,150	p53	p21	7157	1026	Gene	Gene	gene|compound|START_ENTITY gene|nmod|expression expression|compound|END_ENTITY	Enhanced sensitivity to cis-diamminedichloroplatinum -LRB- II -RRB- of a human carcinoma cell line with mutated p53 gene by cyclin-dependent kinase inhibitor p21 -LRB- WAF1 -RRB- expression .
12854173	0	p53	21,24	p21	26,29	p53	p21	7157	1026	Gene	Gene	Expressions|appos|START_ENTITY Expressions|appos|END_ENTITY	Expressions of PCNA , p53 , p21 -LRB- WAF-1 -RRB- and cell proliferation in fetal esophageal epithelia : comparative study with adult esophageal lesions from subjects at high-incidence area for esophageal_cancer in Henan , _ North_China .
14707287	0	p53	32,35	p21	68,71	p53	p21	22060(Tax:10090)	22070(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|nsubj|expression regulates|dobj|END_ENTITY	Prostate-specific expression of p53 -LRB- R172L -RRB- differentially regulates p21 , Bax , and mdm2 to inhibit prostate_cancer progression and prolong survival .
15069711	0	p53	28,31	p21	52,55	p53	p21	7157	1026	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Expression of p21 -LRB- WAF1 -RRB- and p53 and polymorphism of p21 -LRB- WAF1 -RRB- gene in gastric_carcinoma .
15099943	0	p53	30,33	p21	36,39	p53	p21	7157	644914	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|expression expression|amod|END_ENTITY	Radiation_therapy induces the p53 -LRB- + -RRB- p21 -LRB- - -RRB- expression in squamous_cell_carcinomas of the uterine cervix .
15263796	0	p53	186,189	p21	76,79	p53	p21	7157	1026	Gene	Gene	Rb|dep|START_ENTITY proteins|appos|Rb correlation|nmod|proteins patterns|dep|correlation patterns|nmod|END_ENTITY	Expression patterns of cyclins D1 , E and cyclin-dependent kinase inhibitors p21 -LRB- Waf1/Cip1 -RRB- and p27 -LRB- Kip1 -RRB- in urothelial_carcinoma : correlation with other cell-cycle-related proteins -LRB- Rb , p53 , Ki-67 and PCNA -RRB- and clinicopathological features .
15507241	0	p53	46,49	p21	12,15	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY independent|nmod|pathway independent|amod|END_ENTITY	Increase in p21 expression independent of the p53 pathway in bleomycin-induced lung_fibrosis .
15655109	0	p53	60,63	p21	68,71	p53	p21	7157	1026	Gene	Gene	component|nmod|START_ENTITY component|parataxis|senescence senescence|nsubj|END_ENTITY	The p400 E1A-associated protein is a novel component of the p53 -- > p21 senescence pathway .
15678852	0	p53	27,30	p21	39,42	p53	p21	7157	644914	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Prognostic significance of p53 and ras p21 protein expression in surgically treated non-small_cell_lung_carcinoma .
15685034	0	p53	0,3	p21	51,54	p53	p21	7157	1026	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|independent independent|nmod|activation activation|amod|END_ENTITY	p53 modulates radiation sensitivity independent of p21 transcriptional activation .
15735718	0	p53	20,23	p21	13,16	p53	p21	7157	644914	Gene	Gene	damage|nummod|START_ENTITY END_ENTITY|nmod|damage	Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities .
16012042	0	p53	42,45	p21	8,11	p53	p21	7157	644914	Gene	Gene	mutations|compound|START_ENTITY associated|nmod|mutations associated|nsubjpass|Loss Loss|nmod|expression expression|amod|END_ENTITY	Loss of p21 expression is associated with p53 mutations and increased cell proliferation and p27 expression is associated with apoptosis in maxillary_sinus_squamous_cell_carcinoma .
16054204	0	p53	58,61	p21	102,105	p53	p21	7157	644914	Gene	Gene	allele|compound|START_ENTITY allele|nmod|codon codon|nmod|END_ENTITY	Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21 , jointly mediate cervical_cancer susceptibility among Indian women .
16261158	0	p53	52,55	p21	19,22	p53	p21	7157	1026	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|transcripts transcripts|amod|END_ENTITY	Multiple alternate p21 transcripts are regulated by p53 in human cells .
16448826	0	p53	120,123	p21	14,17	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	function|compound|START_ENTITY oligodeoxynucleotides|nmod|function oligodeoxynucleotides|nsubj|effect effect|nmod|antisense antisense|amod|END_ENTITY	The effect of p21 antisense oligodeoxynucleotides on the radiosensitivity of nasopharyngeal_carcinoma cells with normal p53 function .
16537920	0	p53	15,18	p21	109,112	p53	p21	7157	1026	Gene	Gene	Acetylation|nmod|START_ENTITY induces|nsubj|Acetylation induces|dobj|expression expression|nmod|END_ENTITY	Acetylation of p53 at lysine 373/382 by the histone_deacetylase inhibitor depsipeptide induces expression of p21 -LRB- Waf1/Cip1 -RRB- .
16616141	0	p53	86,89	p21	93,96	p53	p21	7157	644914	Gene	Gene	properties|nmod|START_ENTITY enhance|dobj|properties enhance|nmod|promoter promoter|amod|END_ENTITY	Evidence that low doses of Taxol enhance the functional transactivatory properties of p53 on p21 waf promoter in MCF-7 breast_cancer cells .
16739126	0	p53	65,68	p21	81,84	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Arsenite inhibits p53 phosphorylation , DNA binding activity , and p53 target gene p21 expression in mouse epidermal JB6 cells .
16837908	0	p53	40,43	p21	45,48	p53	p21	7157	1026	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the cell cycle regulators p53 , p21 -LRB- WAF1/CIP1 -RRB- and p16 -LRB- INK4a -RRB- in human endometrial_adenocarcinoma .
16951143	0	p53	0,3	p21	72,75	p53	p21	7157	644914	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|promoters promoters|nmod|END_ENTITY	p53 is preferentially recruited to the promoters of growth_arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts .
16998811	0	p53	55,58	p21	83,86	p53	p21	7157	1026	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17317670	0	p53	95,98	p21	66,69	p53	p21	7157	1026	Gene	Gene	CDA1|nmod|START_ENTITY CDA1|dobj|END_ENTITY	Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21 -LRB- Waf1/Cip1 -RRB- by activating p53 and MEK/ERK1/2 MAPK pathways .
17339230	0	p53	71,74	p21	32,35	p53	p21	7157	644914	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	c-Abl tyrosine kinase activates p21 transcription via interaction with p53 .
17395400	0	p53	69,72	p21	49,52	p53	p21	7157	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
17483019	0	p53	116,119	p21	34,37	p53	p21	7157	644914	Gene	Gene	pathway|amod|START_ENTITY lines|nmod|pathway induces|nmod|lines induces|dobj|expression expression|amod|END_ENTITY	Bacillus Calmette-Gu rin induces p21 expression in human transitional carcinoma cell lines via an immediate early , p53 independent pathway .
17536310	0	p53	20,23	p21	31,34	p53	p21	7157	1026	Gene	Gene	Immunoreactivity|nmod|START_ENTITY Immunoreactivity|appos|Bcl-2 Bcl-2|amod|END_ENTITY	Immunoreactivity of p53 , Mdm2 , p21 -LRB- WAF1/CIP1 -RRB- Bcl-2 , and Bax in soft tissue sarcomas : correlation with histologic grade .
17585201	0	p53	40,43	p21	0,3	p53	p21	7157	1026	Gene	Gene	stability|compound|START_ENTITY regulator|nmod|stability regulator|nsubj|END_ENTITY	p21 -LRB- CDKN1A -RRB- is a negative regulator of p53 stability .
17760650	0	p53	15,18	p21	28,31	p53	p21	7157	644914	Gene	Gene	START_ENTITY|appos|VEGF_C VEGF_C|appos|END_ENTITY	Expressions of p53 , VEGF_C , p21 : could they be used in preoperative evaluation of lymph_node_metastasis of esophageal_squamous_cell_carcinoma ?
18024214	0	p53	102,105	p21	117,120	p53	p21	7157	1026	Gene	Gene	kinases|compound|START_ENTITY deregulation|nmod|kinases deregulation|nmod|END_ENTITY	Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21 - / - HCT116 colon_cancer cells .
18263706	0	p53	16,19	p21	104,107	p53	p21	7157	644914	Gene	Gene	activity|compound|START_ENTITY activity|dep|upregulation upregulation|amod|END_ENTITY	HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells : p21 upregulation and G2/M phase cell cycle arrest .
18269916	0	p53	27,30	p21	13,16	p53	p21	7157	644914	Gene	Gene	cells|nummod|START_ENTITY p65|nmod|cells END_ENTITY|nmod|p65	Induction of p21 by p65 in p53 null cells treated with Doxorubicin .
18644983	0	p53	116,119	p21	52,55	p53	p21	7157	1026	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|dobj|gene gene|amod|END_ENTITY	Modulation of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/Cip1 -RRB- gene by Zac1 through the antagonistic regulators p53 and histone_deacetylase_1 in HeLa Cells .
18719376	0	p53	0,3	p21	19,22	p53	p21	7157	644914	Gene	Gene	Binding|compound|START_ENTITY Binding|nmod|promoter promoter|amod|END_ENTITY	p53 Binding to the p21 promoter is dependent on the nature of DNA damage .
18763134	0	p53	13,16	p21	38,41	p53	p21	7157	1026	Gene	Gene	downstream|compound|START_ENTITY Mechanism|nmod|downstream effectors|nsubj|Mechanism effectors|dobj|END_ENTITY	Mechanism of p53 downstream effectors p21 and Gadd45 in DNA damage surveillance .
19001415	0	p53	52,55	p21	66,69	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|xcomp|induce induce|dobj|expression expression|amod|END_ENTITY	Monocytic_leukemia zinc finger -LRB- MOZ -RRB- interacts with p53 to induce p21 expression and cell-cycle arrest .
19147538	0	p53	37,40	p21	97,100	p53	p21	403869(Tax:9615)	644914	Gene	Gene	pathway|compound|START_ENTITY model|nmod|pathway Establishment|nmod|model Establishment|nmod|inhibitor inhibitor|amod|END_ENTITY	Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor .
19249676	0	p53	142,145	p21	33,36	p53	p21	7157	644914	Gene	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced switch|nmod|apoptosis provides|dobj|switch provides|nsubj|downregulation downregulation|nmod|END_ENTITY	MDM2-dependent downregulation of p21 and hnRNP_K provides a switch between apoptosis and growth_arrest induced by pharmacologically activated p53 .
19428175	0	p53	96,99	p21	55,58	p53	p21	7157	1026	Gene	Gene	independent|nmod|START_ENTITY expression|amod|independent expression|amod|END_ENTITY	Gambogic_acid down-regulates MDM2 oncogene and induces p21 -LRB- Waf1/CIP1 -RRB- expression independent of p53 .
19491257	0	p53	16,19	p21	146,149	p53	p21	7157	644914	Gene	Gene	polymorphisms|nummod|START_ENTITY polymorphisms|nmod|gene gene|amod|END_ENTITY	A novel type of p53 pathway dysfunction in chronic_lymphocytic_leukemia resulting from two interacting single nucleotide polymorphisms within the p21 gene .
19843844	0	p53	0,3	p21	117,120	p53	p21	7157	644914	Gene	Gene	theories|nummod|START_ENTITY revisited|nsubj|theories revisited|ccomp|reveal reveal|dobj|patterns patterns|nmod|promoter promoter|amod|END_ENTITY	p53 Pre - and post-binding event theories revisited : stresses reveal specific and dynamic p53-binding patterns on the p21 gene promoter .
20622899	0	p53	59,62	p21	125,128	p53	p21	7157	1026	Gene	Gene	START_ENTITY|nmod|targets targets|nmod|END_ENTITY	PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21 .
20871630	0	p53	73,76	p21	0,3	p53	p21	7157	1026	Gene	Gene	activation|compound|START_ENTITY induced|nmod|activation apoptosis|acl|induced protect|nmod|apoptosis protect|nsubj|END_ENTITY	p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation .
21148311	0	p53	68,71	p21	40,43	p53	p21	7157	644914	Gene	Gene	independent|nmod|START_ENTITY inhibition|amod|independent inhibition|nmod|turnover turnover|amod|END_ENTITY	14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53 .
21220944	0	p53	63,66	p21	75,78	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	targets|nummod|START_ENTITY targets|amod|END_ENTITY	Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways .
21368573	0	p53	70,73	p21	0,3	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	program|compound|START_ENTITY maintains|dobj|program loop|acl:relcl|maintains component|nmod|loop component|nsubj|END_ENTITY	p21 -LRB- WAF1 -RRB- is component of a positive feedback loop that maintains the p53 transcriptional program .
21402054	0	p53	124,127	p21	145,148	p53	p21	7157	1026	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Loss of p21 -LRB- Sdi1 -RRB- expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21 -LRB- Sdi1 -RRB- gene promoter .
21528264	0	p53	67,70	p21	28,31	p53	p21	7157	1026	Gene	Gene	expression|compound|START_ENTITY Correlation|dep|expression Correlation|nmod|END_ENTITY	Correlation between reduced p21 -LRB- WAF1/CIP1 -RRB- expression and abnormal p53 expression in esophageal_carcinomas .
21559680	0	p53	21,24	p21	87,90	p53	p21	7157	644914	Gene	Gene	exclusion|nmod|START_ENTITY controls|nsubj|exclusion controls|nmod|reduction reduction|nmod|expression expression|nmod|inhibitor inhibitor|amod|END_ENTITY	Nuclear exclusion of p53 controls DNA-synthesis through reduction in the expression of p21 inhibitor of cyclin-dependent_kinase-2 .
21606339	0	p53	0,3	p21	38,41	p53	p21	7157	644914	Gene	Gene	START_ENTITY|amod|binding binding|nmod|nucleosomes nucleosomes|nmod|promoter promoter|amod|END_ENTITY	p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation .
21787748	0	p53	64,67	p21	16,19	p53	p21	7157	644914	Gene	Gene	sites|nmod|START_ENTITY proteins|nmod|sites proteins|amod|END_ENTITY	Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation .
21791360	0	p53	82,85	p21	41,44	p53	p21	7157	1026	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Human_papillomavirus_type_16 E6 inhibits p21 -LRB- WAF1 -RRB- transcription independently of p53 by inactivating p150 -LRB- Sal2 -RRB- .
21796649	0	p53	149,152	p21	169,172	p53	p21	7157	644914	Gene	Gene	upregulation|nmod|START_ENTITY associated|nmod|upregulation associated|nmod|proteins proteins|amod|END_ENTITY	Inhibitory effects of antagonists of growth_hormone_releasing_hormone on experimental_prostate_cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins .
21796649	0	p53	184,187	p21	169,172	p53	p21	7157	644914	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Inhibitory effects of antagonists of growth_hormone_releasing_hormone on experimental_prostate_cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins .
21933903	0	p53	41,44	p21	83,86	p53	p21	7157	1026	Gene	Gene	tetramer|compound|START_ENTITY structure|nmod|tetramer bound|nsubj|structure bound|nmod|element element|appos|END_ENTITY	Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A -LRB- p21 -RRB- p53-response element .
22135025	0	p53	55,58	p21	19,22	p53	p21	7157	644914	Gene	Gene	predicts|nsubj|START_ENTITY Expression|parataxis|predicts Expression|nmod|p53 p53|nummod|END_ENTITY	Expression of p53 , p21 and cyclin_D1 in penile_cancer : p53 predicts poor prognosis .
22165824	0	p53	20,23	p21	0,3	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY protects|dobj|mice protects|nsubj|END_ENTITY	p21 protects `` Super p53 '' mice from the radiation-induced gastrointestinal_syndrome .
22244827	0	p53	90,93	p21	131,134	p53	p21	7157	644914	Gene	Gene	mechanism|nmod|START_ENTITY overexpression|nsubj|mechanism overexpression|nmod|suppression suppression|amod|E1A-dependent E1A-dependent|dep|END_ENTITY	A novel apoptotic mechanism of genetically engineered adenovirus-mediated_tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression .
22427654	0	p53	90,93	p21	26,29	p53	p21	7157	1026	Gene	Gene	factors|compound|START_ENTITY requires|dobj|factors requires|nsubj|induction induction|nmod|expression expression|amod|END_ENTITY	Sulforaphane induction of p21 -LRB- Cip1 -RRB- cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent .
22468256	0	p53	14,17	p21	24,27	p53	p21	7157	644914	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
22825333	0	p53	86,89	p21	27,30	p53	p21	7157	1026	Gene	Gene	tumors|nummod|START_ENTITY protein|nmod|tumors protein|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of p21 -LRB- waf1 -RRB- protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications .
22995373	0	p53	60,63	p21	65,68	p53	p21	7157	644914	Gene	Gene	bax|compound|START_ENTITY bax|dep|END_ENTITY	Immunohistochemistry with apoptotic-antiapoptotic proteins -LRB- p53 , p21 , bax , bcl-2 -RRB- , c-kit , telomerase , and metallothionein as a diagnostic aid in benign , borderline , and malignant serous and mucinous ovarian_tumors .
23177619	0	p53	46,49	p21	31,34	p53	p21	7157	1026	Gene	Gene	proteins|compound|START_ENTITY analysis|appos|proteins analysis|nmod|WAF/CIP1 WAF/CIP1|amod|END_ENTITY	Correlation analysis of c-myc , p21 -LRB- WAF/CIP1 -RRB- , p53 , C-erbB-2 and COX-2 proteins in esophageal_squamous_cell_carcinoma .
23382584	0	p53	36,39	p21	32,35	p53	p21	7157	644914	Gene	Gene	status|compound|START_ENTITY status|amod|END_ENTITY	Association of p21 , p21 p27 and p21 p53 status to histological subtypes and prognosis in low-stage_epithelial_ovarian_cancer .
23470540	0	p53	24,27	p21	51,54	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY inhibition|nsubj|effects inhibition|nmod|expression expression|amod|END_ENTITY	Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression .
23665218	0	p53	0,3	p21	125,128	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	efficiently|nmod:npmod|START_ENTITY effectors|advmod|efficiently effectors|dobj|END_ENTITY	p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21 , Puma , and Noxa .
23665236	0	p53	93,96	p21	74,77	p53	p21	7157	1026	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|amod|independent independent|amod|END_ENTITY	EVI1 targets Np63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon_cancer cells .
24134839	0	p53	24,27	p21	48,51	p53	p21	7157	644914	Gene	Gene	suppressor|compound|START_ENTITY Preferential|nmod|suppressor Preferential|nmod|sites sites|amod|END_ENTITY	Preferential binding of p53 tumor suppressor to p21 promoter sites that contain inverted repeats capable of forming cruciform structure .
24212661	0	p53	25,28	p21	86,89	p53	p21	7157	644914	Gene	Gene	Expression|compound|START_ENTITY Impact|nmod|Expression Dependent|nsubj|Impact Dependent|nmod|Status Status|amod|END_ENTITY	The Prognostic Impact of p53 Expression on Sporadic Colorectal_Cancer Is Dependent on p21 Status .
24451377	0	p53	139,142	p21	105,108	p53	p21	7157	644914	Gene	Gene	cascade|compound|START_ENTITY expression|nmod|cascade expression|amod|END_ENTITY	The Chinese herb isolate yuanhuacine -LRB- YHL-14 -RRB- induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade .
24594805	0	p53	46,49	p21	163,166	p53	p21	7157	644914	Gene	Gene	part|compound|START_ENTITY domain|nmod|part Interaction|nmod|domain involved|nsubjpass|Interaction involved|nmod|promoter promoter|amod|END_ENTITY	Interaction between transactivation domain of p53 and middle part of TBP-like_protein -LRB- TLP -RRB- is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter .
24868967	0	p53	10,13	p21	36,39	p53	p21	7157	1026	Gene	Gene	START_ENTITY|nmod|interaction interaction|nmod|proteins proteins|amod|END_ENTITY	-LSB- Roles of p53 in the interaction of p21 and cell cycle proteins induced by benzo _ -LSB- a -RSB- _ pyrene -RSB- .
25532599	0	p53	5,8	p21	0,3	p53	p21	7157	644914	Gene	Gene	TP53BP1|compound|START_ENTITY polymorphisms|compound|TP53BP1 END_ENTITY|appos|polymorphisms	p21 , p53 , TP53BP1 and p73 polymorphisms and the risk of gastric_cardia_adenocarcinoma in a Chinese population .
25773855	0	p53	65,68	p21	70,73	p53	p21	7157	644914	Gene	Gene	Modulating|nummod|START_ENTITY Modulating|nummod|END_ENTITY	Silibilin-Induces Apoptosis in Breast_Cancer Cells by Modulating p53 , p21 , Bak and Bcl-xl Pathways .
25835715	0	p53	14,17	p21	19,22	p53	p21	7157	1026	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|establishing establishing|nsubj|END_ENTITY	Expression of p53 , p21 -LRB- CIP1/WAF1 -RRB- and eIF4E in the adjacent tissues of oral_squamous_cell_carcinoma : establishing the molecular boundary and a cancer progression model .
26680804	0	p53	116,119	p21	48,51	p53	p21	7157	1026	Gene	Gene	Status|compound|START_ENTITY Relationship|nmod|Status Expression|dep|Relationship Expression|nmod|END_ENTITY	Expression of Cyclin-dependent Kinase Inhibitor p21 -LRB- WAF1/CIP1 -RRB- in Non-small_Cell_Lung_Carcinomas : Relationship with p53 Status and Proliferative Activity .
7577479	0	p53	23,26	p21	18,21	p53	p21	7157	644914	Gene	Gene	ras|nummod|START_ENTITY ras|nummod|END_ENTITY	Expression of ras p21 , p53 and c-erbB-2 in advanced breast_cancer and response to first line hormonal therapy .
7832809	0	p53	0,3	p21	57,60	p53	p21	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	p53 controls proliferation of early B lineage cells by a p21 -LRB- WAF1/Cip1 -RRB- - independent pathway .
7912978	0	p53	33,36	p21	54,57	p53	p21	7157	644914	Gene	Gene	EGF-receptor|nummod|START_ENTITY Expression|nmod|EGF-receptor v-erb|nsubj|Expression v-erb|dobj|END_ENTITY	Expression of EGF , EGF-receptor , p53 , v-erb B and ras p21 in colorectal_neoplasms by immunostaining paraffin-embedded tissues .
7936668	0	p53	128,131	p21	83,86	p53	p21	7157	1026	Gene	Gene	absence|nmod|START_ENTITY expression|nmod|absence expression|compound|END_ENTITY	Induction of differentiation in human promyelocytic_HL-60_leukemia cells activates p21 , WAF1/CIP1 , expression in the absence of p53 .
8619835	0	p53	112,115	p21	60,63	p53	p21	7157	1026	Gene	Gene	containing|dobj|START_ENTITY cells|acl|containing suppresses|nmod|cells suppresses|dobj|expression expression|amod|END_ENTITY	DNA-dependent_protein_kinase inhibitor -LRB- OK-1035 -RRB- suppresses p21 expression in HCT116 cells containing wild-type p53 induced by adriamycin .
8625071	0	p53	27,30	p21	39,42	p53	p21	7157	644914	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of p53 and ras p21 expression in nonsmall cell lung_cancer .
8727942	0	p53	32,35	p21	44,47	p53	p21	7157	644914	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Immunohistochemical analysis of p53 and ras p21 expression in colorectal_adenomas and early carcinomas .
8945609	0	p53	35,38	p21	40,43	p53	p21	7157	644914	Gene	Gene	START_ENTITY|appos|genes genes|amod|END_ENTITY	Mutations and polymorphisms in the p53 , p21 and p16 genes in oral_carcinomas of Indian betel quid chewers .
9120716	0	p53	30,33	p21	65,68	p53	p21	7157	1026	Gene	Gene	protein|compound|START_ENTITY Relationship|nmod|protein Relationship|xcomp|express express|dobj|protein protein|amod|END_ENTITY	Relationship between abnormal p53 protein and failure to express p21 protein in human breast_carcinomas .
9177263	0	p53	55,58	p21	39,42	p53	p21	7157	644914	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	In vitro transcriptional activation of p21 promoter by p53 .
9215397	0	p53	29,32	p21	14,17	p53	p21	7157	644914	Gene	Gene	products|compound|START_ENTITY products|amod|END_ENTITY	Expression of p21 and mutant p53 gene products in residual prostatic tumor cells after radical radiotherapy .
9215868	0	p53	102,105	p21	16,19	p53	p21	7157	1026	Gene	Gene	cervix|nmod|START_ENTITY Introduction|nmod|cervix Introduction|nmod|gene gene|amod|END_ENTITY	Introduction of p21 -LRB- Waf1/Cip1 -RRB- gene into a carcinoma cell line of the uterine cervix with inactivated p53 .
9218130	0	p53	17,20	p21	49,52	p53	p21	7157	1026	Gene	Gene	protein|compound|START_ENTITY protein|nmod|mRNA mRNA|amod|END_ENTITY	Modifications of p53 protein and accumulation of p21 and gadd45 mRNA in TGF-beta_1 growth inhibited cells .
9224526	0	p53	26,29	p21	75,78	p53	p21	7157	644914	Gene	Gene	Accumulation|nmod|START_ENTITY associated|nsubjpass|Accumulation associated|nmod|expression expression|amod|END_ENTITY	Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression .
9230213	0	p53	76,79	p21	14,17	p53	p21	7157	644914	Gene	Gene	gamma-irradiation|nmod|START_ENTITY induction|nmod|gamma-irradiation induction|amod|END_ENTITY	p53-dependent p21 induction following gamma-irradiation without concomitant p53 induction in a human peripheral_neuroepithelioma cell line .
9233781	0	p53	32,35	p21	70,73	p53	p21	7157	644914	Gene	Gene	binding|nmod|START_ENTITY evidence|nmod|binding genes|nmod|evidence genes|nsubj|sites sites|nmod|END_ENTITY	In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation .
9236898	0	p53	57,60	p21	4,7	p53	p21	7157	644914	Gene	Gene	expression|compound|START_ENTITY Ras|nmod|expression Ras|dobj|immunoreactivity immunoreactivity|amod|END_ENTITY	Ras p21 protein immunoreactivity and its relationship to p53 expression and prognosis in gallbladder_and_extrahepatic_biliary_carcinoma .
9252195	0	p53	24,27	p21	151,154	p53	p21	7157	1026	Gene	Gene	accumulation|nmod|START_ENTITY correlates|nsubj|accumulation correlates|dobj|END_ENTITY	Nuclear accumulation of p53 correlates significantly with clinical features and inversely with the expression of the cyclin-dependent kinase inhibitor p21 -LRB- WAF1/CIP1 -RRB- in pancreatic_cancer .
9275025	0	p53	54,57	p21	11,14	p53	p21	7157	1026	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|Absence Absence|nmod|expression expression|amod|END_ENTITY	Absence of p21 expression is associated with abnormal p53 in human breast_carcinomas .
9575175	0	p53	61,64	p21	94,97	p53	p21	7157	1026	Gene	Gene	upstream|nmod|START_ENTITY acts|advmod|upstream acts|xcomp|regulate regulate|dobj|induction induction|nmod|END_ENTITY	Serine/threonine protein phosphatase_type_5 acts upstream of p53 to regulate the induction of p21 -LRB- WAF1/Cip1 -RRB- and mediate growth arrest .
9607571	0	p53	51,54	p21	25,28	p53	p21	7157	644914	Gene	Gene	protein|compound|START_ENTITY related|nmod|protein related|nsubjpass|expression expression|nmod|END_ENTITY	Infrequent expression of p21 is related to altered p53 protein in pancreatic_carcinoma .
9664113	0	p53	13,16	p21	18,21	p53	p21	7157	644914	Gene	Gene	START_ENTITY|appos|regulation regulation|compound|END_ENTITY	Differential p53 , p21 , mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53 .
9664113	0	p53	94,97	p21	18,21	p53	p21	7157	644914	Gene	Gene	overexpress|dobj|START_ENTITY regulation|acl:relcl|overexpress regulation|compound|END_ENTITY	Differential p53 , p21 , mdm2 and Rb regulation in glioma cell lines that overexpress wild-type p53 .
9685373	0	p53	80,83	p21	49,52	p53	p21	7157	1026	Gene	Gene	cells|nummod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	A farnesyl-protein transferase inhibitor induces p21 expression and G1 block in p53 wild type tumor cells .
9786925	0	p53	132,135	p21	65,68	p53	p21	7157	1026	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53 .
9811471	0	p53	152,155	p21	124,127	p53	p21	7157	644914	Gene	Gene	independent|nmod|START_ENTITY independent|nmod|inhibition inhibition|nmod|activity activity|nmod|END_ENTITY	Lovastatin mediated G1_arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27 , independent of p53 .
9826721	0	p53	97,100	p21	111,114	p53	p21	7157	644914	Gene	Gene	failure|nmod|START_ENTITY associated|nmod|failure associated|xcomp|induce induce|dobj|expression expression|amod|END_ENTITY	The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21 -LRB- BAX -RRB- expression .
9873247	0	p53	31,34	p21	36,39	p53	p21	7157	1026	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A clinicopathological study of p53 , p21 -LRB- WAF1/CIP1 -RRB- and cyclin_D1 expression in human prostate_cancers .
10203181	0	p53	128,131	p21WAF1/CIP1	76,88	p53	p21WAF1/CIP1	7157	1026	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Ultraviolet radiation down-regulates expression of the cell-cycle inhibitor p21WAF1/CIP1 in human cancer cells independently of p53 .
14761977	0	p53	61,64	p21WAF1/CIP1	32,44	p53	p21WAF1/CIP1	7157	1026	Gene	Gene	independent|nmod|START_ENTITY END_ENTITY|appos|independent	MDM2 is a negative regulator of p21WAF1/CIP1 , independent of p53 .
22190353	0	p53	20,23	p21WAF1/CIP1	31,43	p53	p21WAF1/CIP1	7157	1026	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death .
9072003	0	p53	157,160	p21WAF1/CIP1	0,12	p53	p21WAF1/CIP1	7157	1026	Gene	Gene	mutations|compound|START_ENTITY associated|nmod|mutations associated|nsubj|expression expression|amod|END_ENTITY	p21WAF1/CIP1 and MDM2 expression in non-Hodgkin 's _ lymphoma and their relationship to p53 status : a p53 + , MDM2 - , _ p21-immunophenotype associated with missense p53 mutations .
9926942	0	p53	56,59	p21WAF1/CIP1	98,110	p53	p21WAF1/CIP1	7157	1026	Gene	Gene	transcription|compound|START_ENTITY transcription|nmod|promoter promoter|amod|END_ENTITY	The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter .
10749849	0	p53	100,103	p21WAF1/Cip1	111,123	p53	p21WAF1/Cip1	7157	1026	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	The gut-enriched Kruppel-like factor -LRB- Kruppel-like factor 4 -RRB- mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter .
21526487	0	p53	86,89	p21waf1/cip1	72,84	p53	p21waf1/cip1	7157	1026	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Effect of human_papillomavirus on cell cycle-related proteins p16INK4A , p21waf1/cip1 , p53 and cyclin_D1 in sinonasal inverted_papilloma and laryngeal_carcinoma .
24074410	0	p53	125,128	p21waf1/cip1	36,48	p53	p21waf1/cip1	7157	1026	Gene	Gene	downmodulation|nmod|START_ENTITY enhancers|nmod|downmodulation enhancers|nsubj|upregulation upregulation|nmod|END_ENTITY	EZH2-shRNA-mediated upregulation of p21waf1/cip1 and its transcriptional enhancers with concomitant downmodulation of mutant p53 in pancreatic_ductal_adenocarcinoma .
7995520	0	p53	42,45	p21waf1/cip1	124,136	p53	p21waf1/cip1	7157	1026	Gene	Gene	requires|dobj|START_ENTITY requires|xcomp|induce induce|dobj|END_ENTITY	Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1 .
8760300	0	p53	100,103	p21waf1/cip1	29,41	p53	p21waf1/cip1	301300(Tax:10116)	114851(Tax:10116)	Gene	Gene	proteins|compound|START_ENTITY defect|nmod|proteins underlies|dobj|defect underlies|nsubj|loss loss|nmod|induction induction|amod|END_ENTITY	Selective loss of endogenous p21waf1/cip1 induction underlies the G1 checkpoint defect of monomeric p53 proteins .
9100069	0	p53	100,103	p21waf1/cip1	47,59	p53	p21waf1/cip1	7157	1026	Gene	Gene	immunohistochemistry|compound|START_ENTITY correlation|nmod|immunohistochemistry Expression|dep|correlation Expression|nmod|p53 p53|acl|induced induced|dobj|END_ENTITY	Expression of the p53 induced tumor suppressor p21waf1/cip1 in ovarian_carcinomas : correlation with p53 and Ki-67 immunohistochemistry .
9100069	0	p53	18,21	p21waf1/cip1	47,59	p53	p21waf1/cip1	7157	1026	Gene	Gene	START_ENTITY|acl|induced induced|dobj|END_ENTITY	Expression of the p53 induced tumor suppressor p21waf1/cip1 in ovarian_carcinomas : correlation with p53 and Ki-67 immunohistochemistry .
9861340	0	p53	123,126	p21waf1/cip1	48,60	p53	p21waf1/cip1	7157	1026	Gene	Gene	status|compound|START_ENTITY relationship|nmod|status Expression|dep|relationship Expression|nmod|END_ENTITY	Expression of cyclin dependent kinase inhibitor p21waf1/cip1 in premalignant and malignant_oral_lesions : relationship with p53 status .
10226946	0	p53	73,76	p27	78,81	p53	p27	7157	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
11706071	0	p53	52,55	p27	18,21	p53	p27	7157	3429	Gene	Gene	combined|nmod|START_ENTITY protein|acl|combined protein|amod|END_ENTITY	Low expression of p27 protein combined with altered p53 and Rb/p16 expression status is associated with increased expression of cyclin_A and cyclin_B1 in diffuse_large_B-cell_lymphomas .
16998811	0	p53	55,58	p27	72,75	p53	p27	7157	3429	Gene	Gene	analysis|appos|START_ENTITY analysis|appos|p16 p16|appos|END_ENTITY	Immunohistochemical analysis of pRb2/p130 , VEGF , EZH2 , p53 , p16 -LRB- INK4A -RRB- , p27 -LRB- KIP1 -RRB- , p21 -LRB- WAF1 -RRB- , Ki-67 expression patterns in gastric_cancer .
17395400	0	p53	69,72	p27	54,57	p53	p27	7157	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression of the regulatory cell cycle proteins p21 , p27 , p14 , p16 , p53 , mdm2 , and cyclin E in bone marrow biopsies with acute_myeloid_leukemia .
19597334	0	p53	7,10	p27	12,15	p53	p27	22060(Tax:10090)	12576(Tax:10090)	Gene	Gene	failed|nmod|START_ENTITY failed|nsubj|END_ENTITY	Unlike p53 , p27 failed to exhibit an anti-tumor genetic interaction with Ku80 .
22468256	0	p53	14,17	p27	29,32	p53	p27	7157	3429	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
27033900	0	p53	128,131	p27	123,126	p53	p27	7157	10671	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27 , p53 , bcl-2 in canine breast_cancer cells .
23449360	0	p53	97,100	p28	51,54	p53	p28	7157	9527	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	A first-in-class , first-in-human , phase I trial of p28 , a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours .
12750254	0	p53	28,31	p29ING4	0,7	p53	p29ING4	7157	51147	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	p29ING4 and p28ING5 bind to p53 and p300 , and enhance p53 activity .
10518217	0	p53	45,48	p300	21,25	p53	p300	7157	2033	Gene	Gene	response|compound|START_ENTITY regulates|dobj|response END_ENTITY|acl:relcl|regulates	A novel cofactor for p300 that regulates the p53 response .
11511361	0	p53	57,60	p300	36,40	p53	p300	7157	2033	Gene	Gene	response|compound|START_ENTITY activity|nmod|response activity|amod|END_ENTITY	A TPR motif cofactor contributes to p300 activity in the p53 response .
11591713	0	p53	39,42	p300	13,17	p53	p300	7157	2033	Gene	Gene	stability|compound|START_ENTITY regulation|nmod|stability role|nmod|regulation role|nmod|END_ENTITY	Dual role of p300 in the regulation of p53 stability .
12499368	0	p53	29,32	p300	66,70	p53	p300	7157	2033	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|nmod|END_ENTITY	DNA-dependent acetylation of p53 by the transcription coactivator p300 .
12690203	0	p53	22,25	p300	60,64	p53	p300	7157	2033	Gene	Gene	Polyubiquitination|nmod|START_ENTITY ligase|nsubj|Polyubiquitination ligase|dobj|activity activity|nmod|END_ENTITY	Polyubiquitination of p53 by a ubiquitin ligase activity of p300 .
14612423	0	p53	29,32	p300	83,87	p53	p300	7157	2033	Gene	Gene	domain|nmod|START_ENTITY binds|nsubj|domain binds|nmod|END_ENTITY	The proline repeat domain of p53 binds directly to the transcriptional coactivator p300 and allosterically controls DNA-dependent acetylation of p53 .
15337767	0	p53	111,114	p300	67,71	p53	p300	7157	2033	Gene	Gene	domain|compound|START_ENTITY homology|nmod|domain peptides|nmod|homology homology|nmod|peptides homology|dobj|domain domain|nmod|binds binds|amod|END_ENTITY	The N-terminal interferon-binding domain -LRB- IBiD -RRB- homology domain of p300 binds to peptides with homology to the p53 transactivation domain .
15509808	0	p53	87,90	p300	42,46	p53	p300	7157	2033	Gene	Gene	acetylation|nmod|START_ENTITY acetylation|amod|binding binding|nmod|stimulates stimulates|amod|END_ENTITY	Interferon_regulatory_factor_1 binding to p300 stimulates DNA-dependent acetylation of p53 .
16229810	0	p53	150,153	p300	27,31	p53	p300	7157	2033	Gene	Gene	effects|nmod|START_ENTITY factors|dep|effects Jun/Fos|dobj|factors activates|ccomp|Jun/Fos activates|nsubj|complex complex|amod|END_ENTITY	An estrogen_receptor-alpha / p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors : repressive effects of p53 on BRCA-1 transcription .
17438265	0	p53	97,100	p300	16,20	p53	p300	7157	2033	Gene	Gene	subdomains|nmod|START_ENTITY spanning|dobj|subdomains sequence|acl|spanning END_ENTITY|nmod|sequence	Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53 .
18155245	0	p53	70,73	p300	87,91	p53	p300	7157	2033	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|domains domains|amod|END_ENTITY	Differential recognition of phosphorylated transactivation domains of p53 by different p300 domains .
18612383	0	p53	98,101	p300	19,23	p53	p300	7157	2033	Gene	Gene	induced|nmod|START_ENTITY downregulation|acl|induced protect|nmod|downregulation required|xcomp|protect required|nsubjpass|domain domain|nmod|END_ENTITY	The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53 .
19166313	0	p53	31,34	p300	85,89	p53	p300	7157	2033	Gene	Gene	motifs|nmod|START_ENTITY transactivation|nsubj|motifs transactivation|nmod|domain domain|nmod|END_ENTITY	Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation .
19363523	0	p53	102,105	p300	110,114	p53	p300	7157	2033	Gene	Gene	START_ENTITY|nmod|domains domains|amod|END_ENTITY	Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2 .
21057544	0	p53	14,17	p300	38,42	p53	p300	7157	2033	Gene	Gene	acetylation|compound|START_ENTITY mediates|dobj|acetylation mediates|nmod|END_ENTITY	p85a mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response .
21059157	0	p53	41,44	p300	92,96	p53	p300	7157	2033	Gene	Gene	accumulation|compound|START_ENTITY accumulation|nmod|decrease decrease|amod|END_ENTITY	SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease , eventually leading to apoptosis .
21513714	0	p53	94,97	p300	45,49	p53	p300	7157	2033	Gene	Gene	activity|nmod|START_ENTITY modulate|dobj|activity cooperate|xcomp|modulate cooperate|nmod|END_ENTITY	The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53 .
22074660	0	p53	45,48	p300	108,112	p53	p300	7157	2033	Gene	Gene	transactivation|nummod|START_ENTITY inhibits|dobj|transactivation inhibits|advcl|regulating regulating|dobj|END_ENTITY	Chromatin remodelling protein SMAR1 inhibits p53 dependent transactivation by regulating acetyl transferase p300 .
23010591	0	p53	81,84	p300	55,59	p53	p300	7157	2033	Gene	Gene	features|nmod|START_ENTITY features|nmod|END_ENTITY	Structural features of human histone acetyltransferase p300 and its complex with p53 .
23796514	0	p53	60,63	p300	40,44	p53	p300	7157	2033	Gene	Gene	binding|nmod|START_ENTITY acetylation|amod|binding END_ENTITY|nmod|acetylation	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
23796514	0	p53	79,82	p300	40,44	p53	p300	7157	2033	Gene	Gene	acetylation|compound|START_ENTITY END_ENTITY|nmod|acetylation	S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation .
26100016	0	p53	46,49	p300	0,4	p53	p300	22060(Tax:10090)	328572(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p300 regulates liver functions by controlling p53 and C/EBP family proteins through multiple signaling pathways .
9094623	0	p53	38,41	p300	0,4	p53	p300	7157	2033	Gene	Gene	induction|compound|START_ENTITY cosegregates|nmod|induction cosegregates|nsubj|END_ENTITY	p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis .
9257185	0	p53	102,105	p300	9,13	p53	p300	7157	2033	Gene	Gene	activity|compound|START_ENTITY Roles|nmod|activity Roles|nmod|END_ENTITY	Roles of p300 , pocket proteins , and hTBP in E1A-mediated transcriptional regulation and inhibition of p53 transactivation activity .
9652736	0	p53	29,32	p300	62,66	p53	p300	7157	2033	Gene	Gene	interplay|nmod|START_ENTITY interplay|nmod|END_ENTITY	Functional interplay between p53 and E2F through co-activator p300 .
9890940	0	p53	34,37	p300	9,13	p53	p300	7157	2033	Gene	Gene	stabilization|nmod|START_ENTITY END_ENTITY|nmod|stabilization	Role for p300 in stabilization of p53 in the response to DNA damage .
11076655	0	p53	69,72	p33	42,45	p53	p33	22060(Tax:10090)	16994(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the novel tumour suppressor p33 -LRB- ING1 -RRB- is independent of p53 .
14642087	0	p53	58,61	p33	42,45	p53	p33	7157	3621	Gene	Gene	gene|compound|START_ENTITY Study|nmod|gene Study|nmod|cooperation cooperation|nmod|END_ENTITY	-LSB- Study of cooperation of tumor suppressor p33 -LRB- ING1b -RRB- with p53 gene in hepatocellular_carcinoma -RSB- .
9882325	0	p53	28,31	p33	12,15	p53	p33	7157	3621	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Baculovirus p33 binds human p53 and enhances p53-mediated apoptosis .
2141683	0	p53	0,3	p34cdc2	19,26	p53	p34cdc2	7157	983	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	p53 interacts with p34cdc2 in mammalian cells : implications for cell cycle control and oncogenesis .
2167834	0	p53	0,3	p34cdc2	23,30	p53	p34cdc2	22060(Tax:10090)	12534(Tax:10090)	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|END_ENTITY	p53 is associated with p34cdc2 in transformed cells .
18974112	0	p53	60,63	p37Ing1b	0,8	p53	p37Ing1b	22060(Tax:10090)	26356(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis .
10212189	0	p53	50,53	p38	0,3	p53	p38	7157	5594	Gene	Gene	protein|compound|START_ENTITY phosphorylation|nmod|protein mediates|dobj|phosphorylation mediates|nsubj|kinase kinase|amod|END_ENTITY	p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389 .
10581258	0	p53	25,28	p38	32,35	p53	p38	7157	1432	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation .
10811125	0	p53	97,100	p38	15,18	p53	p38	7157	1432	Gene	Gene	activation|nmod|START_ENTITY kinase|nmod|activation kinase|nsubj|role role|nmod|protein protein|amod|END_ENTITY	A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents .
12071847	0	p53	154,157	p38	27,30	p53	p38	7157	1432	Gene	Gene	stabilizing|dobj|START_ENTITY enhances|advcl|stabilizing enhances|nsubj|activation activation|nmod|kinase kinase|amod|END_ENTITY	UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53 .
12091386	0	p53	94,97	p38	0,3	p53	p38	7157	1432	Gene	Gene	accumulating|dobj|START_ENTITY regulates|advcl|accumulating regulates|nsubj|kinase kinase|amod|END_ENTITY	p38 kinase regulates nitric_oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa_B-dependent transcription and stabilization by serine 15 phosphorylation .
12807754	0	p53	92,95	p38	9,12	p53	p38	7157	1432	Gene	Gene	induction|compound|START_ENTITY Roles|nmod|induction Roles|nmod|END_ENTITY	Roles of p38 - and c-jun_NH2-terminal_kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis .
15642743	0	p53	18,21	p38	41,44	p53	p38	7157	1432	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope .
15963507	0	p53	4,7	p38	33,36	p53	p38	7157	1432	Gene	Gene	synergized|nsubjpass|START_ENTITY synergized|nmod|MAPK MAPK|amod|END_ENTITY	The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11 ' - dideoxyverticillin-induced G2/M arrest .
16244358	0	p53	118,121	p38	173,176	p53	p38	22060(Tax:10090)	26416(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|dep|role role|nmod|kinase kinase|amod|END_ENTITY	Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation : role of p38 MAP kinase .
16297369	0	p53	84,87	p38	0,3	p53	p38	7157	1432	Gene	Gene	activation|compound|START_ENTITY regulation|nmod|activation apoptosis|nmod|regulation benzo|dep|apoptosis regulates|dobj|benzo regulates|nsubj|kinase kinase|nummod|END_ENTITY	p38 MAP kinase regulates benzo -LRB- a -RRB- pyrene-induced apoptosis through the regulation of p53 activation .
19020042	0	p53	139,142	p38	24,27	p53	p38	22060(Tax:10090)	26416(Tax:10090)	Gene	Gene	translocation|nmod|START_ENTITY leads|nmod|translocation leads|nsubj|activation activation|nmod|kinase kinase|amod|END_ENTITY	Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1 ,2,3,6 - tetrahydropyridine-treated mice .
19583730	0	p53	56,59	p38	102,105	p53	p38	7157	1432	Gene	Gene	cells|nummod|START_ENTITY cytotoxicity|nmod|cells enhances|dobj|cytotoxicity enhances|nmod|activation activation|amod|END_ENTITY	Dicoumarol enhances doxorubicin-induced cytotoxicity in p53 wild-type urothelial_cancer cells through p38 activation .
20590525	0	p53	10,13	p38	0,3	p53	p38	7157	1432	Gene	Gene	axis|compound|START_ENTITY mediates|nsubj|axis /|ccomp|mediates inhibition|amod|/ inhibition|amod|END_ENTITY	p38 -LRB- MAPK -RRB- / p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition : implication for neurodegeneration .
21059157	0	p53	41,44	p38	62,65	p53	p38	7157	1432	Gene	Gene	accumulation|compound|START_ENTITY accumulation|nmod|decrease decrease|amod|END_ENTITY	SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease , eventually leading to apoptosis .
21519792	0	p53	52,55	p38	18,21	p53	p38	7157	5594	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon_cancer-derived metastatic cells .
21983885	0	p53	24,27	p38	74,77	p53	p38	7157	1432	Gene	Gene	Role|nmod|START_ENTITY kinases|nsubj|Role kinases|dobj|END_ENTITY	Role and interaction of p53 , BAX and the stress-activated protein kinases p38 and JNK in benzo -LRB- a -RRB- pyrene-diolepoxide induced apoptosis in human colon_carcinoma cells .
22342995	0	p53	95,98	p38	0,3	p53	p38	7157	5594	Gene	Gene	stimuli|nmod|START_ENTITY response|nmod|stimuli SH-SY5Y|nsubj|response dictate|xcomp|SH-SY5Y dictate|nsubj|END_ENTITY	p38 -LRB- MAPK -RRB- and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y .
23638878	0	p53	65,68	p38	8,11	p53	p38	7157	5594	Gene	Gene	signaling|dobj|START_ENTITY MAPK|xcomp|signaling MAPK|nsubj|Role Role|nmod|END_ENTITY	Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549_lung_cancer cells .
23859040	0	p53	43,46	p38	77,80	p53	p38	7157	1432	Gene	Gene	activation|compound|START_ENTITY death|nmod|activation death|nmod|END_ENTITY	Epicatechin_gallate induces cell death via p53 activation and stimulation of p38 and JNK in human colon_cancer SW480 cells .
24297112	0	p53	65,68	p38	105,108	p53	p38	7157	1432	Gene	Gene	cells|nmod|START_ENTITY apoptosis|nmod|cells apoptosis|nmod|MAPK MAPK|amod|END_ENTITY	Oridonin induces apoptosis in SW1990 pancreatic_cancer cells via p53 - and caspase-dependent induction of p38 MAPK .
24599959	0	p53	16,19	p38	0,3	p53	p38	7157	1432	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	p38 regulates p53 to control p21Cip1 expression in human epidermal keratinocytes .
18642443	0	p53	26,29	p38_MAPK	38,46	p53	p38 MAPK	7157	1432	Gene	Gene	activates|dobj|START_ENTITY activates|nmod|END_ENTITY	Chk1 inhibition activates p53 through p38_MAPK in tetraploid_cancer cells .
20724307	0	p53	113,116	p38b	131,135	p53	p38b	301300(Tax:10116)	689314(Tax:10116)	Gene	Gene	START_ENTITY|acl|inhibition inhibition|nmod|END_ENTITY	Oestrogen prevents cardiomyocyte apoptosis by suppressing p38a-mediated activation of p53 and by down-regulating p53 inhibition on p38b .
11340630	0	p53	58,61	p51	25,28	p53	p51	7157	8626	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Mutation analysis of the p51 gene and correlation between p53 , p73 , and p51 expressions in prostatic_carcinoma .
10428056	0	p53	0,3	p53	64,67	p53	p53	7157	7157	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	p53 induction by tumor_necrosis_factor-alpha and involvement of p53 in cell death of human oligodendrocytes .
10428056	0	p53	64,67	p53	0,3	p53	p53	7157	7157	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	p53 induction by tumor_necrosis_factor-alpha and involvement of p53 in cell death of human oligodendrocytes .
10448271	0	p53	0,3	p53	71,74	p53	p53	7157	7157	Gene	Gene	mutations|compound|START_ENTITY induced|nsubj|mutations induced|nmod|END_ENTITY	p53 gene mutations and p21 protein expression induced independently of p53 , by TGF-beta and gamma-rays in squamous_cell_carcinoma cells .
10448271	0	p53	71,74	p53	0,3	p53	p53	7157	7157	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|mutations mutations|compound|END_ENTITY	p53 gene mutations and p21 protein expression induced independently of p53 , by TGF-beta and gamma-rays in squamous_cell_carcinoma cells .
10778859	0	p53	11,14	p53	78,81	p53	p53	2768677(Tax:7227)	2768677(Tax:7227)	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Drosophila p53 is a structural and functional homolog of the tumor suppressor p53 .
10778859	0	p53	78,81	p53	11,14	p53	p53	2768677(Tax:7227)	2768677(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Drosophila p53 is a structural and functional homolog of the tumor suppressor p53 .
15150125	0	p53	21,24	p53	86,89	p53	p53	7157	7157	Gene	Gene	induces|dobj|START_ENTITY induces|dep|END_ENTITY	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
15150125	0	p53	86,89	p53	21,24	p53	p53	7157	7157	Gene	Gene	induces|dep|START_ENTITY induces|dobj|END_ENTITY	Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and , independently of p53 , sensitizes apoptosis-reluctant cells to tumor necrosis factor .
15337531	0	p53	130,133	p53	54,57	p53	p53	7157	7157	Gene	Gene	function|compound|START_ENTITY increase|dobj|function mechanisms|acl:relcl|increase activation|dep|mechanisms activation|nmod|END_ENTITY	Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2 : two mechanisms that cooperatively increase p53 function in colon_cancer cells .
15337531	0	p53	54,57	p53	130,133	p53	p53	7157	7157	Gene	Gene	activation|nmod|START_ENTITY activation|dep|mechanisms mechanisms|acl:relcl|increase increase|dobj|function function|compound|END_ENTITY	Ras inhibition leads to transcriptional activation of p53 and down-regulation of Mdm2 : two mechanisms that cooperatively increase p53 function in colon_cancer cells .
15358376	0	p53	34,37	p53	68,71	p53	p53	7157	7157	Gene	Gene	domain|compound|START_ENTITY domain|nmod|fusion fusion|nmod|transactivation transactivation|compound|END_ENTITY	Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide .
15358376	0	p53	68,71	p53	34,37	p53	p53	7157	7157	Gene	Gene	transactivation|compound|START_ENTITY fusion|nmod|transactivation domain|nmod|fusion domain|compound|END_ENTITY	Over-expression of the human MDM2 p53 binding domain by fusion to a p53 transactivation peptide .
15603096	0	p53	33,36	p53	49,52	p53	p53	7157	7157	Gene	Gene	expression|compound|START_ENTITY expression|appos|mutation mutation|compound|END_ENTITY	Vulvar_intraepithelial_neoplasia p53 expression , p53 gene mutation and HPV in recurrent/progressive cases .
15603096	0	p53	49,52	p53	33,36	p53	p53	7157	7157	Gene	Gene	mutation|compound|START_ENTITY expression|appos|mutation expression|compound|END_ENTITY	Vulvar_intraepithelial_neoplasia p53 expression , p53 gene mutation and HPV in recurrent/progressive cases .
16318864	0	p53	20,23	p53	44,47	p53	p53	7157	7157	Gene	Gene	overexpression|compound|START_ENTITY overexpression|nmod|END_ENTITY	The associations of p53 overexpression with p53 codon 72 genetic polymorphism in esophageal_cancer .
16318864	0	p53	44,47	p53	20,23	p53	p53	7157	7157	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|compound|END_ENTITY	The associations of p53 overexpression with p53 codon 72 genetic polymorphism in esophageal_cancer .
16971506	0	p53	112,115	p53	89,92	p53	p53	7157	7157	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels .
16971506	0	p53	89,92	p53	112,115	p53	p53	7157	7157	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels .
19009304	0	p53	130,133	p53	55,58	p53	p53	7157	7157	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Establishment of ponasterone_A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells , cell growth suppression by p53 expression and the suppression mechanism .
19009304	0	p53	55,58	p53	130,133	p53	p53	7157	7157	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Establishment of ponasterone_A-inducible the wild-type p53 protein-expressing clones from HSC-1 cells , cell growth suppression by p53 expression and the suppression mechanism .
19121375	0	p53	31,34	p53	84,87	p53	p53	7157	7157	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Soft-shell clam -LRB- Mya arenaria -RRB- p53 : a structural and functional comparison to human p53 .
19121375	0	p53	84,87	p53	31,34	p53	p53	7157	7157	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Soft-shell clam -LRB- Mya arenaria -RRB- p53 : a structural and functional comparison to human p53 .
19166840	0	p53	33,36	p53	96,99	p53	p53	22060(Tax:10090)	22060(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY regulator|nmod|pathway FKBP25|appos|regulator induces|nsubj|FKBP25 induces|dobj|degradation degradation|nmod|END_ENTITY	FKBP25 , a novel regulator of the p53 pathway , induces the degradation of MDM2 and activation of p53 .
19166840	0	p53	96,99	p53	33,36	p53	p53	22060(Tax:10090)	22060(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY induces|dobj|degradation induces|nsubj|FKBP25 FKBP25|appos|regulator regulator|nmod|pathway pathway|compound|END_ENTITY	FKBP25 , a novel regulator of the p53 pathway , induces the degradation of MDM2 and activation of p53 .
20124408	0	p53	48,51	p53	65,68	p53	p53	7157	7157	Gene	Gene	START_ENTITY|acl:relcl|binds binds|dobj|END_ENTITY	SCH529074 , a small molecule activator of mutant p53 , which binds p53 DNA binding domain -LRB- DBD -RRB- , restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53 .
20124408	0	p53	65,68	p53	48,51	p53	p53	7157	7157	Gene	Gene	binds|dobj|START_ENTITY END_ENTITY|acl:relcl|binds	SCH529074 , a small molecule activator of mutant p53 , which binds p53 DNA binding domain -LRB- DBD -RRB- , restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53 .
25211335	0	p53	14,17	p53	53,56	p53	p53	2768677(Tax:7227)	2768677(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|genes genes|compound|END_ENTITY	Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells .
25211335	0	p53	53,56	p53	14,17	p53	p53	2768677(Tax:7227)	2768677(Tax:7227)	Gene	Gene	genes|compound|START_ENTITY protein|nmod|genes protein|compound|END_ENTITY	Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells .
8694840	0	p53	55,58	p53	79,82	p53	p53	22060(Tax:10090)	22060(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	ADP-ribosylation of wild-type p53 in vitro : binding of p53 protein to specific p53 consensus sequence prevents its modification .
8694840	0	p53	79,82	p53	55,58	p53	p53	22060(Tax:10090)	22060(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	ADP-ribosylation of wild-type p53 in vitro : binding of p53 protein to specific p53 consensus sequence prevents its modification .
8836878	0	p53	20,23	p53	75,78	p53	p53	301300(Tax:10116)	301300(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	ADP-ribosylation of p53 tumor suppressor protein : mutant but not wild-type p53 is modified .
8836878	0	p53	75,78	p53	20,23	p53	p53	301300(Tax:10116)	301300(Tax:10116)	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	ADP-ribosylation of p53 tumor suppressor protein : mutant but not wild-type p53 is modified .
9524714	0	p53	19,22	p53	68,71	p53	p53	22060(Tax:10090)	22060(Tax:10090)	Gene	Gene	response|amod|START_ENTITY response|nmod|END_ENTITY	An HLA-restricted , p53 specific immune response from HLA transgenic p53 knockout mice .
9524714	0	p53	68,71	p53	19,22	p53	p53	22060(Tax:10090)	22060(Tax:10090)	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	An HLA-restricted , p53 specific immune response from HLA transgenic p53 knockout mice .
9649429	0	p53	0,3	p53	85,88	p53	p53	7157	7157	Gene	Gene	cleavage|compound|START_ENTITY cleavage|dep|activity activity|nmod|END_ENTITY	p53 facilitates pRb cleavage in IL-3-deprived cells : novel pro-apoptotic activity of p53 .
9649429	0	p53	85,88	p53	0,3	p53	p53	7157	7157	Gene	Gene	activity|nmod|START_ENTITY cleavage|dep|activity cleavage|compound|END_ENTITY	p53 facilitates pRb cleavage in IL-3-deprived cells : novel pro-apoptotic activity of p53 .
26029824	0	p53	89,92	p62	131,134	p53	p62	7157	23636	Gene	Gene	interaction|nmod|START_ENTITY monitoring|nmod|interaction domains|nsubj|monitoring domains|nmod|subunit subunit|amod|END_ENTITY	Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit .
7831152	0	p53	43,46	p62	39,42	p53	p62	7157	23636	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Mycosis fungoides : expression of C-myc p62 p53 , bcl-2 and PCNA proteins and absence of association with Epstein-Barr_virus .
10227293	0	p53	9,12	p63	0,3	p53	p63	22060(Tax:10090)	22061(Tax:10090)	Gene	Gene	homologue|compound|START_ENTITY homologue|nsubj|END_ENTITY	p63 is a p53 homologue required for limb and epidermal morphogenesis .
10452616	0	p53	0,3	p63	19,22	p53	p63	7157	8626	Gene	Gene	members|nummod|START_ENTITY members|amod|END_ENTITY	p53 Family members p63 and p73 are SAM domain-containing proteins .
11136565	0	p53	18,21	p63	32,35	p53	p63	7157	8626	Gene	Gene	Expression|nmod|START_ENTITY Expression|acl|homologue homologue|dobj|END_ENTITY	Expression of the p53 homologue p63 in early cervical neoplasia .
11181441	0	p53	11,14	p63	23,26	p53	p63	7157	8626	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	NBP is the p53 homolog p63 .
11238924	0	p53	110,113	p63	60,63	p53	p63	7157	8626	Gene	Gene	domain|compound|START_ENTITY interaction|nmod|domain down-regulate|nmod|interaction down-regulate|dobj|END_ENTITY	A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain .
11238924	0	p53	42,45	p63	60,63	p53	p63	7157	8626	Gene	Gene	forms|nmod|START_ENTITY subset|nmod|forms down-regulate|nsubj|subset down-regulate|dobj|END_ENTITY	A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain .
11474290	0	p53	7,10	p63	0,3	p53	p63	7157	8626	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	p63 , a p53 homologue , is a selective nuclear marker of myoepithelial cells of the human breast .
11477076	0	p53	126,129	p63	73,76	p53	p63	7157	8626	Gene	Gene	distinguish|nmod|START_ENTITY distinguish|dobj|domain domain|amod|END_ENTITY	High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53 .
11522642	0	p53	34,37	p63	0,3	p53	p63	22060(Tax:10090)	22061(Tax:10090)	Gene	Gene	loss|compound|START_ENTITY associated|nmod|loss associated|nsubjpass|expression expression|amod|END_ENTITY	p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice .
11592094	0	p53	18,21	p63	33,36	p53	p63	7157	8626	Gene	Gene	Expression|nmod|START_ENTITY homologues|nsubj|Expression homologues|dobj|END_ENTITY	Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric_cancer .
11893750	0	p53	46,49	p63	67,70	p53	p63	7157	8626	Gene	Gene	mutants|compound|START_ENTITY interaction|nmod|mutants inhibits|nsubj|interaction inhibits|dobj|activities activities|amod|END_ENTITY	Physical interaction with human tumor-derived p53 mutants inhibits p63 activities .
11957139	0	p53	27,30	p63	51,54	p53	p63	7157	8626	Gene	Gene	members|nummod|START_ENTITY members|amod|END_ENTITY	Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis .
12027449	0	p53	0,3	p63	20,23	p53	p63	22060(Tax:10090)	22061(Tax:10090)	Gene	Gene	p51|nummod|START_ENTITY p51|appos|END_ENTITY	p53 gene family p51 -LRB- p63 -RRB- - encoded , secondary transactivator p51B -LRB- TAp63alpha -RRB- occurs without forming an immunoprecipitable complex with MDM2 , but responds to genotoxic stress by accumulation .
15308639	0	p53	82,85	p63	95,98	p53	p63	7157	8626	Gene	Gene	homologs|compound|START_ENTITY homologs|amod|END_ENTITY	CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73 .
15608418	0	p53	0,3	p63	5,8	p53	p63	7157	8626	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	p53 , p63 and p73 expression in squamous_cell_carcinomas of the head and neck and their response to cisplatin exposure .
15837625	0	p53	109,112	p63	40,43	p53	p63	22060(Tax:10090)	22061(Tax:10090)	Gene	Gene	family|compound|START_ENTITY functions|nmod|family evidence|nmod|functions predisposition|dep|evidence predisposition|nmod|mutant mutant|nmod|END_ENTITY	Tumor predisposition in mice mutant for p63 and p73 : evidence for broader_tumor suppressor functions for the p53 family .
15846087	0	p53	29,32	p63	56,59	p53	p63	7157	8626	Gene	Gene	functions|compound|START_ENTITY suppressor|dobj|functions suppressor|nmod|END_ENTITY	The tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro .
16831876	0	p53	135,138	p63	90,93	p53	p63	7157	8626	Gene	Gene	family|compound|START_ENTITY factor|nmod|family factor|nsubj|Glyoxalase_II Glyoxalase_II|appos|enzyme enzyme|nmod|END_ENTITY	Glyoxalase_II , a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73 , is a pro-survival factor of the p53 family .
16870177	0	p53	108,111	p63	53,56	p53	p63	7157	8626	Gene	Gene	distinct|nmod|START_ENTITY requirements|acl:relcl|distinct reveals|dobj|requirements reveals|nsubj|Derivation Derivation|nmod|sequence sequence|nmod|END_ENTITY	Derivation of the consensus DNA-binding sequence for p63 reveals unique requirements that are distinct from p53 .
16959223	0	p53	28,31	p63	0,3	p53	p63	7157	8626	Gene	Gene	family|compound|START_ENTITY members|nmod|family END_ENTITY|appos|members	p63 and p73 , members of the p53 gene family , transactivate PKCdelta .
17401431	0	p53	53,56	p63	22,25	p53	p63	7157	8626	Gene	Gene	gain|compound|START_ENTITY involved|nmod|gain involved|nsubj|interactions interactions|nmod|END_ENTITY	Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function ?
18026135	0	p53	71,74	p63	25,28	p53	p63	7157	8626	Gene	Gene	sequence|nummod|START_ENTITY complex|nmod|sequence carcinogenesis|amod|complex presence|nmod|carcinogenesis presence|amod|END_ENTITY	p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis .
18626511	0	p53	58,61	p63	24,27	p53	p63	7157	8626	Gene	Gene	transactivation|nmod|START_ENTITY mutants|nmod|transactivation mutants|amod|END_ENTITY	Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes .
18626511	0	p53	58,61	p63	69,72	p53	p63	7157	8626	Gene	Gene	transactivation|nmod|START_ENTITY mutants|nmod|transactivation effects|nmod|mutants and/or|nsubj|effects and/or|dobj|genes genes|amod|responsive responsive|amod|END_ENTITY	Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes .
19458240	0	p53	16,19	p63	0,3	p53	p63	7157	8626	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	p63 antagonizes p53 to promote the survival of embryonic neural precursor cells .
20140014	0	p53	54,57	p63	67,70	p53	p63	7157	8626	Gene	Gene	interacting|nmod|START_ENTITY proteins|acl|interacting basis|nmod|proteins homologs|nsubj|basis homologs|dobj|END_ENTITY	Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73 .
20484388	0	p53	30,33	p63	0,3	p53	p63	7157	8626	Gene	Gene	ancestors|nmod|START_ENTITY END_ENTITY|appos|ancestors	p63 and p73 , the ancestors of p53 .
20485546	0	p53	22,25	p63	27,30	p53	p63	22060(Tax:10090)	22061(Tax:10090)	Gene	Gene	suppressors|nummod|START_ENTITY suppressors|nummod|END_ENTITY	The tumor suppressors p53 , p63 , and p73 are regulators of microRNA processing complex .
20818419	0	p53	45,48	p63	64,67	p53	p63	7157	8626	Gene	Gene	members|compound|START_ENTITY members|amod|END_ENTITY	PRIMA-1 -LRB- MET -RRB- / APR-246 targets mutant forms of p53 family members p63 and p73 .
20972454	0	p53	7,10	p63	20,23	p53	p63	7157	8626	Gene	Gene	subverts|nsubj|START_ENTITY subverts|dobj|control control|amod|END_ENTITY	Mutant p53 subverts p63 control over KLF4 expression in keratinocytes .
21114965	0	p53	26,29	p63	45,48	p53	p63	22060(Tax:10090)	22061(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY members|nsubj|expression members|dobj|END_ENTITY	Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood .
21760596	0	p53	76,79	p63	0,3	p53	p63	7157	8626	Gene	Gene	interacting|nmod|START_ENTITY suppressor|acl|interacting suppressor|nsubj|END_ENTITY	p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53 .
22203497	0	p53	7,10	p63	16,19	p53	p63	7157	8626	Gene	Gene	uses|nsubj|START_ENTITY uses|dobj|END_ENTITY	Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome .
22361592	0	p53	17,20	p63	90,93	p53	p63	7157	8626	Gene	Gene	mutants|compound|START_ENTITY overlapping|nsubj|mutants overlapping|nmod|END_ENTITY	Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63 .
22468256	0	p53	14,17	p63	19,22	p53	p63	7157	8626	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
22549865	0	p53	36,39	p63	18,21	p53	p63	7157	8626	Gene	Gene	family|compound|START_ENTITY Janus|nmod|family -RSB-|nsubj|Janus -RSB-|advcl|-LSB- -LSB-|dobj|faces faces|nmod|END_ENTITY	-LSB- The two faces of p63 , Janus of the p53 gene family -RSB- .
22641291	0	p53	157,160	p63	53,56	p53	p63	7157	8626	Gene	Gene	increases|nmod|START_ENTITY induces|nmod|increases induces|dobj|accumulations accumulations|nmod|p53 p53|nummod|END_ENTITY	Fludarabine_nucleoside induces accumulations of p53 , p63 and p73 in the nuclei of human B-lymphoid cell lines , with cytosolic and mitochondrial increases in p53 .
23420876	0	p53	22,25	p63	0,3	p53	p63	7157	8626	Gene	Gene	repressor|compound|START_ENTITY repressor|nsubj|END_ENTITY	p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis .
23924551	0	p53	39,42	p63	34,37	p53	p63	7157	8626	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Immunohistochemical expression of p63 , p53 in urinary_bladder_carcinoma .
25536625	0	p53	34,37	p63	39,42	p53	p63	7157	8626	Gene	Gene	expression|nmod|START_ENTITY expression|amod|c-myc c-myc|amod|END_ENTITY	Immunohistochemical expression of p53 , p63 , c-myc , p21 -LRB- WAF1/cip1 -RRB- and p27 -LRB- kip1 -RRB- proteins in urothelial_bladder_carcinoma : correlation with clinicopathological parameters .
27019188	0	p53	92,95	p63	76,79	p53	p63	7157	8626	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression targeting|advcl|regulate targeting|dobj|END_ENTITY	MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression .
10657951	0	p53	18,21	p63alpha	32,40	p53	p63alpha	7157	8626	Gene	Gene	Expression|nmod|START_ENTITY Expression|acl|homologue homologue|dobj|END_ENTITY	Expression of the p53 homologue p63alpha and deltaNp63alpha in normal and neoplastic cells .
11600462	0	p53	18,21	p63alpha	32,40	p53	p63alpha	7157	8626	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Expression of the p53 homologue p63alpha and DeltaNp63alpha in the neoplastic sequence of Barrett 's _ oesophagus : correlation with morphology and p53 protein .
10870681	0	p53	165,168	p65	74,77	p53	p65	7157	5970	Gene	Gene	oncogene|iobj|START_ENTITY oncogene|nsubj|analysis analysis|nmod|expression expression|appos|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
15073170	0	p53	0,3	p65	105,108	p53	p65	7157	5970	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|mechanism mechanism|acl|involving involving|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal_S6_kinase_1 .
18269916	0	p53	27,30	p65	20,23	p53	p65	7157	5970	Gene	Gene	cells|nummod|START_ENTITY END_ENTITY|nmod|cells	Induction of p21 by p65 in p53 null cells treated with Doxorubicin .
20818423	0	p53	82,85	p68	17,20	p53	p68	7157	10657	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	The RNA helicase p68 modulates expression and function of the / \ 133 isoform -LRB- s -RRB- of p53 , and is inversely associated with / \ 133p53 expression in breast_cancer .
10049720	0	p53	129,132	p73	27,30	p53	p73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY level|nmod|protein fibroblasts|nmod|level fibroblasts|nsubj|expression expression|nmod|END_ENTITY	Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein .
10362118	0	p53	50,53	p73	14,17	p53	p73	7157	7161	Gene	Gene	p53|compound|START_ENTITY related|nmod|p53 related|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p73 , a novel protein related to the p53 tumour suppressor p53 , and apoptosis in cholangiocellular_carcinoma of the liver .
10362118	0	p53	72,75	p73	14,17	p53	p73	7157	7161	Gene	Gene	related|nmod|START_ENTITY related|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p73 , a novel protein related to the p53 tumour suppressor p53 , and apoptosis in cholangiocellular_carcinoma of the liver .
10408409	0	p53	66,69	p73	18,21	p53	p73	7157	7161	Gene	Gene	alteration|compound|START_ENTITY independent|nmod|alteration lung_cancer|appos|independent increased|nmod|lung_cancer increased|nsubjpass|expression expression|nmod|END_ENTITY	The expression of p73 is increased in lung_cancer , independent of p53 gene alteration .
10606650	0	p53	18,21	p73	0,3	p53	p73	7157	7161	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	p73 competes with p53 and attenuates its response in a human ovarian_cancer cell line .
10753204	0	p53	196,199	p73	153,156	p53	p73	7157	7161	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|loss loss|nmod|imprinting imprinting|nmod|expression expression|amod|END_ENTITY	Molecular alterations of p73 in human esophageal squamous_cell_carcinomas : loss of heterozygosity occurs frequently ; loss of imprinting and elevation of p73 expression may be related to defective p53 .
10753204	0	p53	196,199	p73	25,28	p53	p73	7157	7161	Gene	Gene	related|nmod|START_ENTITY occurs|parataxis|related occurs|nsubj|alterations alterations|nmod|END_ENTITY	Molecular alterations of p73 in human esophageal squamous_cell_carcinomas : loss of heterozygosity occurs frequently ; loss of imprinting and elevation of p73 expression may be related to defective p53 .
10884390	0	p53	44,47	p73	82,85	p53	p73	7157	7161	Gene	Gene	mutants|compound|START_ENTITY interaction|nmod|mutants interaction|nmod|END_ENTITY	Physical and functional interaction between p53 mutants and different isoforms of p73 .
10894779	0	p53	31,34	p73	50,53	p53	p73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	An anti-apoptotic role for the p53 family member , p73 , during developmental neuron_death .
11034215	0	p53	13,16	p73	27,30	p53	p73	7157	7161	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Role for the p53 homologue p73 in E2F-1-induced apoptosis .
11231003	0	p53	74,77	p73	63,66	p53	p73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	Aquaporin_3 , a glycerol and water transporter , is regulated by p73 of the p53 family .
11245471	0	p53	44,47	p73	19,22	p53	p73	7157	7161	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	A possible role of p73 on the modulation of p53 level through MDM2 .
11275986	0	p53	45,48	p73	27,30	p53	p73	7157	7161	Gene	Gene	protein|compound|START_ENTITY a|nmod|protein inactivation|appos|a inactivation|nmod|END_ENTITY	Functional inactivation of p73 , a homolog of p53 tumor suppressor protein , by human_papillomavirus E6 proteins .
11850851	0	p53	45,48	p73	69,72	p53	p73	397926(Tax:8355)	7161	Gene	Gene	interact|compound|START_ENTITY raised|nmod|interact raised|nmod|END_ENTITY	Monoclonal antibodies raised against Xenopus p53 interact with human p73 .
12101410	0	p53	0,3	p73	45,48	p53	p73	7157	7161	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|N N|compound|END_ENTITY	p53 induces the expression of its antagonist p73 Delta N , establishing an autoregulatory feedback loop .
12639967	0	p53	18,21	p73	30,33	p53	p73	7157	7161	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|homolog homolog|dobj|END_ENTITY	Regulation of the p53 homolog p73 by adenoviral oncogene E1A .
12726854	0	p53	0,3	p73	69,72	p53	p73	7157	7161	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|stab stab|nmod|back back|nmod|END_ENTITY	p53 mutations and resistance to chemotherapy : A stab in the back for p73 .
12850759	0	p53	1,4	p73	70,73	p53	p73	7157	7161	Gene	Gene	mutations|compound|START_ENTITY mutations|dep|stab stab|nmod|back back|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- p53 mutations and resistance to chemotherapy : a stab in the back for p73 ? -RSB- .
12880967	0	p53	103,106	p73	15,18	p53	p73	7157	7161	Gene	Gene	protein|compound|START_ENTITY accumulation|nmod|protein induces|dobj|accumulation forced|ccomp|induces needs|dep|forced needs|xcomp|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12880967	0	p53	103,106	p73	45,48	p53	p73	7157	7161	Gene	Gene	protein|compound|START_ENTITY accumulation|nmod|protein induces|dobj|accumulation induces|nsubj|expression expression|amod|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12880967	0	p53	5,8	p73	15,18	p53	p73	7157	7161	Gene	Gene	needs|nsubj|START_ENTITY needs|xcomp|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12880967	0	p53	5,8	p73	45,48	p53	p73	7157	7161	Gene	Gene	needs|nsubj|START_ENTITY needs|dep|forced forced|ccomp|induces induces|nsubj|expression expression|amod|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12934108	0	p53	64,67	p73	0,3	p53	p73	7157	7161	Gene	Gene	express|dobj|START_ENTITY cells|acl:relcl|express proliferation|nmod|cells suppress|dobj|proliferation suppress|nsubj|END_ENTITY	p73 can suppress the proliferation of cells that express mutant p53 .
14676279	0	p53	25,28	p73	45,48	p53	p73	7157	7161	Gene	Gene	response|nmod|START_ENTITY target|nsubj|response target|nmod|overexpression overexpression|amod|END_ENTITY	Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line .
14719122	0	p53	54,57	p73	33,36	p53	p73	7157	7161	Gene	Gene	related|nmod|START_ENTITY value|acl|related value|nmod|alterations alterations|nmod|gene gene|amod|END_ENTITY	Clinical value of alterations in p73 gene , related to p53 at 1p36 , in human hepatocellular_carcinoma .
14720173	0	p53	4,7	p73	18,21	p53	p73	7157	7161	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|accumulates accumulates|amod|END_ENTITY	The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer_disease brain .
15302867	0	p53	50,53	p73	65,68	p53	p73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	c-Jun regulates the stability and activity of the p53 homologue , p73 .
16271066	0	p53	21,24	p73	0,3	p53	p73	7157	7161	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	p73 , a sophisticated p53 family member in the cancer world .
16481734	0	p53	62,65	p73	50,53	p53	p73	7157	7161	Gene	Gene	homologue|compound|START_ENTITY beta|appos|homologue beta|amod|END_ENTITY	Therapeutic potential of an adenovirus expressing p73 beta , a p53 homologue , against human_papilloma_virus_positive_cervical_cancer in vitro and in vivo .
16741250	0	p53	115,118	p73	14,17	p53	p73	7157	7161	Gene	Gene	lacking|dobj|START_ENTITY cells|acl|lacking apoptosis|nmod|cells overcome|nmod|apoptosis END_ENTITY|xcomp|overcome	CD154 induces p73 to overcome the resistance to apoptosis of chronic_lymphocytic_leukemia cells lacking functional p53 .
16815295	0	p53	84,87	p73	0,3	p53	p73	7157	7161	Gene	Gene	blocking|dobj|START_ENTITY cisplatin|advcl|blocking confer|xcomp|cisplatin confer|nsubj|END_ENTITY	p73 and MDM2 confer the resistance of epidermoid_carcinoma to cisplatin by blocking p53 .
16849542	0	p53	36,39	p73	0,3	p53	p73	7157	7161	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints .
17169329	0	p53	141,144	p73	120,123	p53	p73	7157	7161	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	The expression of phosphatidic_acid_phosphatase_2a , which hydrolyzes lipids to generate diacylglycerol , is regulated by p73 , a member of the p53 family .
17707235	0	p53	70,73	p73	0,3	p53	p73	7157	7161	Gene	Gene	absence|nmod|START_ENTITY suppresses|nmod|absence suppresses|nsubj|END_ENTITY	p73 suppresses polyploidy and aneuploidy in the absence of functional p53 .
17761206	0	p53	14,17	p73	35,38	p53	p73	7157	7161	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of p53 and its homolog , p73 , in HPV DNA positive oesophageal_squamous_cell_carcinomas .
17822668	0	p53	60,63	p73	34,37	p53	p73	7157	7161	Gene	Gene	family|compound|START_ENTITY member|nmod|family regulation|appos|member regulation|nmod|gene gene|amod|END_ENTITY	Transcriptional regulation of the p73 gene , a member of the p53 family , by early_growth_response-1 -LRB- Egr-1 -RRB- .
18026135	0	p53	71,74	p73	0,3	p53	p73	7157	7161	Gene	Gene	sequence|nummod|START_ENTITY complex|nmod|sequence carcinogenesis|amod|complex presence|nmod|carcinogenesis modulates|dobj|presence modulates|nsubj|expression expression|amod|END_ENTITY	p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis .
18260640	0	p53	103,106	p73	4,7	p53	p73	7157	7161	Gene	Gene	homologue|appos|START_ENTITY relative|nmod|homologue displays|advmod|relative displays|nsubj|domain domain|amod|END_ENTITY	The p73 DNA binding domain displays enhanced stability relative to its homologue , the tumor suppressor p53 , and exhibits cooperative DNA binding .
18313527	0	p53	82,85	p73	0,3	p53	p73	7157	7161	Gene	Gene	response|compound|START_ENTITY lack|nmod|response apoptosis|nmod|lack correlates|nmod|apoptosis correlates|nsubj|expression expression|amod|END_ENTITY	p73 protein expression correlates with radiation-induced apoptosis in the lack of p53 response to radiation_therapy for cervical_cancer .
18469517	0	p53	124,127	p73	50,53	p53	p73	7157	7161	Gene	Gene	mutations|compound|START_ENTITY comparison|nmod|mutations Involvement|dep|comparison Involvement|nmod|variants variants|nmod|END_ENTITY	Involvement of N-terminally truncated variants of p73 , deltaTAp73 , in head_and_neck_squamous_cell_cancer : a comparison with p53 mutations .
18801697	0	p53	65,68	p73	26,29	p53	p73	7157	7161	Gene	Gene	shadow|nmod|START_ENTITY rising|nmod|shadow prospects|dep|rising prospects|nmod|END_ENTITY	Therapeutic prospects for p73 and p63 : rising from the shadow of p53 .
20160513	0	p53	50,53	p73	0,3	p53	p73	7157	7161	Gene	Gene	relative|nmod|START_ENTITY protein|dep|relative protein|amod|END_ENTITY	p73 tumor suppressor protein : a close relative of p53 not only in structure but also in anti-cancer approach ?
20305378	0	p53	16,19	p73	33,36	p53	p73	7157	7161	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|acl|signaling signaling|nmod|results results|compound|END_ENTITY	Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis .
20675383	0	p53	45,48	p73	103,106	p53	p73	7157	7161	Gene	Gene	impairment|compound|START_ENTITY due|nmod|impairment adaptation|amod|due Gain|nmod|adaptation leads|nsubj|Gain leads|xcomp|switchover switchover|nmod|p53 p53|nmod|END_ENTITY	Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute_myeloid_leukemia cells .
20812030	0	p53	37,40	p73	90,93	p53	p73	7157	7161	Gene	Gene	cells|nummod|START_ENTITY apoptosis|nmod|cells induces|dobj|apoptosis induces|advcl|activating activating|dobj|expression expression|amod|END_ENTITY	Mdm2 inhibition induces apoptosis in p53 deficient human colon_cancer cells by activating p73 - and E2F1-mediated expression of PUMA and Siva-1 .
21214929	0	p53	69,72	p73	138,141	p53	p73	7157	7161	Gene	Gene	cells|nummod|START_ENTITY cells|nmod|END_ENTITY	a-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant , triple-negative human breast_cancer cells via activating p73 .
21241554	0	p53	63,66	p73	21,24	p53	p73	7157	7161	Gene	Gene	-RSB-|compound|START_ENTITY Effect|nmod|-RSB- Effect|nmod|gene gene|amod|END_ENTITY	-LSB- Effect of exogenous p73 gene on chemosensitivity of wild-type p53 human lung_adenocarcinoma cell A549 -RSB- .
21368881	0	p53	132,135	p73	0,3	p53	p73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	progenitors|nmod|START_ENTITY progenitors|nsubj|results results|amod|END_ENTITY	p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53 .
21976716	0	p53	58,61	p73	0,3	p53	p73	7157	7161	Gene	Gene	Arg72Pro|nummod|START_ENTITY polymorphism|nmod|Arg72Pro polymorphism|amod|END_ENTITY	p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility : a meta-analysis of the literature .
22076304	0	p53	60,63	p73	79,82	p53	p73	7157	7161	Gene	Gene	member|compound|START_ENTITY member|appos|END_ENTITY	Pleomorphic_adenoma_gene-like_2 regulates expression of the p53 family member , p73 , and induces cell cycle block and apoptosis in human promonocytic U937 cells .
22497596	0	p53	8,11	p73	27,30	p53	p73	7157	7161	Gene	Gene	members|compound|START_ENTITY members|amod|END_ENTITY	Role of p53 family members p73 and p63 in human hematological_malignancies .
22508983	0	p53	54,57	p73	0,3	p53	p73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	family|compound|START_ENTITY target|nmod|family RNPC1|appos|target regulated|nmod|RNPC1 regulated|nsubjpass|expression expression|amod|END_ENTITY	p73 expression is regulated by RNPC1 , a target of the p53 family , via mRNA stability .
22952705	0	p53	0,3	p73	29,32	p53	p73	7157	7161	Gene	Gene	inactivation|compound|START_ENTITY upregulates|nsubj|inactivation upregulates|dobj|expression expression|amod|END_ENTITY	p53 inactivation upregulates p73 expression through E2F-1 mediated transcription .
24247721	0	p53	30,33	p73	83,86	p53	p73	7157	7161	Gene	Gene	signaling|compound|START_ENTITY rescues|dobj|signaling rescues|advcl|upregulating upregulating|dobj|END_ENTITY	Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53 .
24874608	0	p53	22,25	p73	13,16	p53	p73	7157	7161	Gene	Gene	couples|nmod|START_ENTITY couples|dobj|END_ENTITY	AMPK couples p73 with p53 in cell fate decision .
26294215	0	p53	148,151	p73	107,110	p53	p73	7157	7161	Gene	Gene	Mutant|nummod|START_ENTITY Activation|nmod|Mutant Activation|compound|END_ENTITY	Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal_Cancer via p73 Activation and Degradation of Mutant p53 .
26294215	0	p53	33,36	p73	107,110	p53	p73	7157	7161	Gene	Gene	Signaling|nummod|START_ENTITY Restores|dobj|Signaling Restores|nmod|Colorectal_Cancer Colorectal_Cancer|nmod|Activation Activation|compound|END_ENTITY	Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal_Cancer via p73 Activation and Degradation of Mutant p53 .
26527653	0	p53	0,3	p73	31,34	p53	p73	22060(Tax:10090)	22062(Tax:10090)	Gene	Gene	Activity|compound|START_ENTITY Dominates|nsubj|Activity Dominates|dobj|That That|nmod|END_ENTITY	p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis .
27074052	0	p53	131,134	p73	14,17	p53	p73	7157	7161	Gene	Gene	status|compound|START_ENTITY mantle_cell_lymphoma|nmod|status induces|nmod|mantle_cell_lymphoma induces|nsubj|Modulation Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle_cell_lymphoma independent of p53 status .
9797131	0	p53	23,26	p73	0,3	p53	p73	7157	7161	Gene	Gene	related|nmod|START_ENTITY gene|acl|related END_ENTITY|appos|gene	p73 , a gene related to p53 , is not mutated in esophageal_carcinomas .
9823311	0	p53	69,72	p73	31,34	p53	p73	7157	7161	Gene	Gene	genes|compound|START_ENTITY regulates|dobj|genes regulates|nsubj|END_ENTITY	The potential tumor suppressor p73 differentially regulates cellular p53 target genes .
9891077	0	p53	43,46	p73	0,3	p53	p73	7157	7161	Gene	Gene	mutants|compound|START_ENTITY inhibited|nmod|mutants inhibited|nsubjpass|function function|amod|END_ENTITY	p73 function is inhibited by tumor-derived p53 mutants in mammalian cells .
10226946	0	p53	73,76	pRb	68,71	p53	pRb	7157	5925	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
10353761	0	p53	97,100	pRb	54,57	p53	pRb	7157	5925	Gene	Gene	alteration|compound|START_ENTITY correlates|nmod|alteration correlates|nmod|expression expression|compound|END_ENTITY	Loss of heterozygosity of the Rb gene correlates with pRb protein expression and associates with p53 alteration in human esophageal_cancer .
10611334	0	p53	28,31	pRb	150,153	p53	pRb	7157	5925	Gene	Gene	exhibit|compound|START_ENTITY compromised|nmod|exhibit compromised|dobj|repair repair|dep|defective defective|nsubj|cells cells|acl|compromised compromised|nmod|function function|compound|END_ENTITY	Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair , whereas cells compromised for pRb function are defective only in global repair .
10899671	0	p53	15,18	pRb	20,23	p53	pRb	7157	5925	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of p53 , pRb , cyclin_D -LRB- 1 -RRB- and cdk4 in human oral and pharyngeal squamous_cell_carcinomas .
11121443	0	p53	0,3	pRb	71,74	p53	pRb	22059(Tax:10090)	19645(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|triggering triggering|dobj|activity activity|nmod|END_ENTITY	p53 regulates myogenesis by triggering the differentiation activity of pRb .
9649429	0	p53	0,3	pRb	16,19	p53	pRb	7157	5925	Gene	Gene	cleavage|compound|START_ENTITY cleavage|compound|END_ENTITY	p53 facilitates pRb cleavage in IL-3-deprived cells : novel pro-apoptotic activity of p53 .
9649429	0	p53	85,88	pRb	16,19	p53	pRb	7157	5925	Gene	Gene	activity|nmod|START_ENTITY cleavage|dep|activity cleavage|compound|END_ENTITY	p53 facilitates pRb cleavage in IL-3-deprived cells : novel pro-apoptotic activity of p53 .
8012775	0	p53	33,36	pT1	48,51	p53	pT1	7157	58492	Gene	Gene	START_ENTITY|nmod|cell cell|amod|END_ENTITY	Immunohistological expression of p53 in primary pT1 transitional cell bladder_cancer in relation to tumour progression .
15998523	0	p53	14,17	pVHL	61,65	p53	pVHL	7157	7428	Gene	Gene	Expression|nmod|START_ENTITY independent|nsubj|Expression independent|nmod|END_ENTITY	Expression of p53 in renal_carcinoma cells is independent of pVHL .
22105368	0	p53	108,111	paired_box_gene_5	27,44	p53	paired box gene 5	7157	5079	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Epigenetic inactivation of paired_box_gene_5 , a novel tumor suppressor gene , through direct upregulation of p53 is associated with prognosis in gastric_cancer patients .
21597718	0	p53	33,36	pcna	85,89	p53	pcna	7157	5111	Gene	Gene	protein|compound|START_ENTITY detection|nmod|protein detection|appos|END_ENTITY	Immunohistochemical detection of p53 protein and proliferating_cell_nuclear_antigen -LRB- pcna -RRB- in salivary-gland_tumors .
25404730	0	p53	0,3	phosphoglycerate_dehydrogenase	35,65	p53	phosphoglycerate dehydrogenase	7157	26227	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	p53 Protein-mediated regulation of phosphoglycerate_dehydrogenase -LRB- PHGDH -RRB- is crucial for the apoptotic response upon serine starvation .
11470783	0	p53	0,3	plasminogen_activator_inhibitor-1	82,115	p53	plasminogen activator inhibitor-1	7157	5054	Gene	Gene	Phosphorylation|compound|START_ENTITY required|nsubjpass|Phosphorylation required|nmod|induction induction|nmod|gene gene|amod|END_ENTITY	p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene by the alkylating agent N-methyl-N ' - nitro-N-nitrosoguanidine .
15735814	0	p53	154,157	plasminogen_activator_inhibitor-1	77,110	p53	plasminogen activator inhibitor-1	22060(Tax:10090)	18787(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY activates|nmod|phosphorylation activates|dobj|gene gene|amod|END_ENTITY	The alkylating carcinogen N-methyl-N ' - nitro-N-nitrosoguanidine activates the plasminogen_activator_inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases .
18469003	0	p53	87,90	plasminogen_activator_inhibitor-1	14,47	p53	plasminogen activator inhibitor-1	7157	5054	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of plasminogen_activator_inhibitor-1 expression by tumor suppressor protein p53 .
26754547	0	p53	45,48	polo-like_kinase_1	10,28	p53	polo-like kinase 1	7157	5347	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Targeting polo-like_kinase_1 , a regulator of p53 , in the treatment of adrenocortical_carcinoma .
23536728	0	p53	25,28	pregnane_X_receptor	56,75	p53	pregnane X receptor	7157	8856	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	Tumor suppressor protein p53 negatively regulates human pregnane_X_receptor activity .
11485412	0	p53	117,120	promyelocytic_leukemia_protein	60,90	p53	promyelocytic leukemia protein	7157	5371	Gene	Gene	bodies|dobj|START_ENTITY bodies|nsubj|colocalizes colocalizes|nmod|END_ENTITY	Human-herpesvirus-8-encoded K8 protein colocalizes with the promyelocytic_leukemia_protein -LRB- PML -RRB- bodies and recruits p53 to the PML bodies .
12810724	0	p53	44,47	promyelocytic_leukemia_protein	4,34	p53	promyelocytic leukemia protein	7157	5371	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	The promyelocytic_leukemia_protein protects p53 from Mdm2-mediated inhibition and degradation .
21057547	0	p53	76,79	promyelocytic_leukemia_protein	42,72	p53	promyelocytic leukemia protein	7157	5371	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	AXIN is an essential co-activator for the promyelocytic_leukemia_protein in p53 activation .
11791186	0	p53	73,76	prostate_specific_antigen	14,39	p53	prostate specific antigen	7157	354	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of prostate_specific_antigen -LRB- PSA -RRB- is negatively regulated by p53 .
11788578	0	p53	14,17	protein_inhibitor_of_activated_Stat1	21,57	p53	protein inhibitor of activated Stat1	7157	8554	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of p53 by protein_inhibitor_of_activated_Stat1 -LRB- PIAS1 -RRB- .
9571186	0	p53	18,21	protein_kinase_C_alpha	33,55	p53	protein kinase C alpha	22060(Tax:10090)	18750(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Regulation of the p53 protein by protein_kinase_C_alpha and protein kinase C zeta .
19339267	0	p53	44,47	receptor_interacting_protein_1	4,34	p53	receptor interacting protein 1	7157	8737	Gene	Gene	induction|compound|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	The receptor_interacting_protein_1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma .
17393088	0	p53	42,45	restin	32,38	p53	restin	7157	28986	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of restin by p53 .
8674005	0	p53	31,34	retinoblastoma	15,29	p53	retinoblastoma	7157	5925	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of retinoblastoma , p53 , p16 -LRB- CDKN2 -RRB- , and p15 genes in human astrocytomas .
15152193	0	p53	79,82	ribosomal_protein_L11	18,39	p53	ribosomal protein L11	7157	6135	Gene	Gene	activation|compound|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	Essential role of ribosomal_protein_L11 in mediating growth inhibition-induced p53 activation .
15314174	0	p53	37,40	ribosomal_protein_L23	44,65	p53	ribosomal protein L23	7157	9349	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of HDM2 and activation of p53 by ribosomal_protein_L23 .
15308643	0	p53	28,31	ribosomal_protein_L5	66,86	p53	ribosomal protein L5	7157	6125	Gene	Gene	ubiquitination|compound|START_ENTITY Inhibition|nmod|ubiquitination Inhibition|nmod|END_ENTITY	Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal_protein_L5 .
20554519	0	p53	93,96	ribosomal_protein_L5	53,73	p53	ribosomal protein L5	7157	6125	Gene	Gene	activation|compound|START_ENTITY activation|amod|END_ENTITY	Perturbation of 60 S ribosomal biogenesis results in ribosomal_protein_L5 - and L11-dependent p53 activation .
23728348	0	p53	36,39	ribosomal_protein_S26	4,25	p53	ribosomal protein S26	7157	6231	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The ribosomal_protein_S26 regulates p53 activity in response to DNA damage .
12355087	0	p53	29,32	securin	6,13	p53	securin	7157	9232	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis .
12403781	0	p53	67,70	securin	33,40	p53	securin	7157	9232	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|inhibition inhibition|nmod|expression expression|compound|END_ENTITY	DNA damage-induced inhibition of securin expression is mediated by p53 .
11593403	0	p53	47,50	ser15	13,18	p53	ser15	7157	3190208(Tax:176280)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|modifications modifications|amod|END_ENTITY	Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation .
8647846	0	p53	0,3	sgk	40,43	p53	sgk	301300(Tax:10116)	29517(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	p53 stimulates promoter activity of the sgk .
14985507	0	p53	46,49	siah-1b	114,121	p53	siah-1b	7157	20438(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|dep|identification identification|nmod|element element|nmod|promoter promoter|amod|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
14985507	0	p53	84,87	siah-1b	114,121	p53	siah-1b	7157	20438(Tax:10090)	Gene	Gene	functional|dep|START_ENTITY element|amod|functional element|nmod|promoter promoter|amod|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
8961277	0	p53	41,44	somatostatin_receptor_3	96,119	p53	somatostatin receptor 3	7157	6753	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Subtype-selective induction of wild-type p53 and apoptosis , but not cell cycle arrest , by human somatostatin_receptor_3 .
22493143	0	p53	22,25	stanniocalcin_1	41,56	p53	stanniocalcin 1	7157	6781	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Synergistic effect of p53 on TSA-induced stanniocalcin_1 expression in human nasopharyngeal_carcinoma cells , CNE2 .
11581300	0	p53	113,116	survivin	25,33	p53	survivin	22060(Tax:10090)	11799(Tax:10090)	Gene	Gene	loss|nmod|START_ENTITY counteracts|nmod|loss counteracts|nsubj|expression expression|nmod|END_ENTITY	Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53 .
16585159	0	p53	71,74	survivin	20,28	p53	survivin	22060(Tax:10090)	11799(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Mitosis-independent survivin gene expression in vivo and regulation by p53 .
10393860	0	p53	117,120	thrombospondin-1	56,72	p53	thrombospondin-1	7157	7057	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Human_cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53 .
9260894	0	p53	76,79	thymidylate_synthase	20,40	p53	thymidylate synthase	22060(Tax:10090)	22171(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Inhibition of mouse thymidylate_synthase promoter activity by the wild-type p53 tumor suppressor protein .
23165212	0	p53	92,95	thymine_DNA_glycosylase	30,53	p53	thymine DNA glycosylase	7157	6996	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of thymine_DNA_glycosylase -LRB- TDG -RRB- by the tumor suppressor protein p53 .
16236433	0	p53	25,28	tissue_inhibitor_of_metalloproteinase-3	53,92	p53	tissue inhibitor of metalloproteinase-3	7157	7078	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|amod|END_ENTITY	Localization of a mutant p53 response element on the tissue_inhibitor_of_metalloproteinase-3 promoter : mutant p53 activities are distinct from wild-type .
7727777	0	p53	161,164	transforming_growth_factor-beta	17,48	p53	transforming growth factor-beta	7157	7040	Gene	Gene	downregulation|nmod|START_ENTITY associated|nmod|downregulation induces|parataxis|associated induces|dobj|sensitivity sensitivity|amod|END_ENTITY	Anti-IgM induces transforming_growth_factor-beta sensitivity in a human B-lymphoma cell line : inhibition of growth is associated with a downregulation of mutant p53 .
10621852	0	p53	26,29	transforming_growth_factor_alpha	31,63	p53	transforming growth factor alpha	7157	7124	Gene	Gene	neu|compound|START_ENTITY neu|dep|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
16705155	0	p53	40,43	tumor	44,49	p53	SRCAP	7157	10847	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation .
25026345	0	p53	130,133	tumor_necrosis_factor-a	32,55	p53	tumor necrosis factor-a	7157	7124	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dep|expression	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
10428056	0	p53	0,3	tumor_necrosis_factor-alpha	17,44	p53	tumor necrosis factor-alpha	7157	7124	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	p53 induction by tumor_necrosis_factor-alpha and involvement of p53 in cell death of human oligodendrocytes .
10428056	0	p53	64,67	tumor_necrosis_factor-alpha	17,44	p53	tumor necrosis factor-alpha	7157	7124	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	p53 induction by tumor_necrosis_factor-alpha and involvement of p53 in cell death of human oligodendrocytes .
11391531	0	p53	98,101	tumor_necrosis_factor-alpha	33,60	p53	tumor necrosis factor-alpha	301300(Tax:10116)	24835(Tax:10116)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|Induction Induction|nmod|expression expression|nmod|END_ENTITY	Induction of Mdr1b expression by tumor_necrosis_factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling .
12397608	0	p53	178,181	tumor_necrosis_factor-alpha	116,143	p53	tumor necrosis factor-alpha	7157	7124	Gene	Gene	c-myc|dep|START_ENTITY c-myc|compound|END_ENTITY	Hydrostatic_pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor_necrosis_factor-alpha , inducible_nitric_oxide_synthase , p53 , c-myc , and bax-alpha , and suppression of bcl-2 .
17283168	0	p53	0,3	tumor_necrosis_factor-alpha	67,94	p53	tumor necrosis factor-alpha	7157	397086(Tax:9823)	Gene	Gene	peptide|compound|START_ENTITY regulates|nsubj|peptide regulates|dobj|expression expression|amod|END_ENTITY	p53 short peptide -LRB- p53pep164 -RRB- regulates lipopolysaccharide-induced tumor_necrosis_factor-alpha factor/cytokine expression .
21541574	0	p53	13,16	tumor_necrosis_factor-alpha	41,68	p53	tumor necrosis factor-alpha	7157	7124	Gene	Gene	Induction|nmod|START_ENTITY DNA-binding|nsubj|Induction DNA-binding|nmod|END_ENTITY	Induction of p53 DNA-binding activity by tumor_necrosis_factor-alpha .
9924699	0	p53	147,150	tumor_necrosis_factor-alpha	30,57	p53	tumor necrosis factor-alpha	7157	7124	Gene	Gene	mutated|dobj|START_ENTITY effects|acl|mutated effects|nmod|END_ENTITY	Combined cytotoxic effects of tumor_necrosis_factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53 .
11716533	0	p53	130,133	tumor_necrosis_factor_alpha	15,42	p53	tumor necrosis factor alpha	7157	7124	Gene	Gene	line|compound|START_ENTITY pathway|nmod|line induces|nmod|pathway induces|nsubj|Combination Combination|nmod|alpha alpha|compound|END_ENTITY	Combination of tumor_necrosis_factor_alpha and interferon alpha induces apoptotic cell death through a c-myc-dependent pathway in p53 mutant H226br non-small-cell_lung_cancer cell line .
17363555	0	p53	7,10	tumor_necrosis_factor_alpha	56,83	p53	tumor necrosis factor alpha	7157	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Mutant p53 enhances nuclear_factor_kappaB activation by tumor_necrosis_factor_alpha in cancer cells .
17897950	0	p53	78,81	tumor_necrosis_factor_alpha	115,142	p53	tumor necrosis factor alpha	7157	7124	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|response response|nmod|END_ENTITY	The deubiquitinating enzyme USP11 controls an IkappaB_kinase_alpha -LRB- IKKalpha -RRB- - p53 signaling pathway in response to tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- .
11694645	0	p53	102,105	uPA	74,77	p53	uPA	7157	5328	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
10910082	0	p53	10,13	vascular_endothelial_growth_factor	117,151	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	suppresses|compound|START_ENTITY angiogenesis|nsubj|suppresses angiogenesis|nmod|suppression suppression|nmod|expression expression|compound|END_ENTITY	Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial_sarcoma by transcriptional suppression of vascular_endothelial_growth_factor expression .
11280795	0	p53	76,79	vascular_endothelial_growth_factor	18,52	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|nmod|END_ENTITY	The expression of vascular_endothelial_growth_factor correlates with mutant p53 and poor prognosis in human breast_cancer .
11720743	0	p53	112,115	vascular_endothelial_growth_factor	14,48	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	mutation|compound|START_ENTITY association|nmod|mutation Expression|dep|association Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in non-small_cell_lung_cancer -LRB- NSCLC -RRB- : association with p53 gene mutation and prognosis .
11844810	0	p53	9,12	vascular_endothelial_growth_factor	54,88	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|expression expression|nmod|mRNA mRNA|compound|END_ENTITY	Aberrant p53 expression correlates with expression of vascular_endothelial_growth_factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell_lung_cancer .
12460743	0	p53	100,103	vascular_endothelial_growth_factor	120,154	p53	vascular endothelial growth factor	301300(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis , mitosis , S phase , and p53 and hepatocytic vascular_endothelial_growth_factor expression after short-term exposure .
12782015	0	p53	10,13	vascular_endothelial_growth_factor	35,69	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	gene|compound|START_ENTITY Effect|nmod|gene transfection|nsubj|Effect transfection|nmod|expression expression|compound|END_ENTITY	Effect of p53 gene transfection on vascular_endothelial_growth_factor expression in endometrial_cancer cells .
12969230	0	p53	98,101	vascular_endothelial_growth_factor	14,48	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor in salivary_gland_carcinomas and its relation to p53 , Ki-67 and prognosis .
15142682	0	p53	15,18	vascular_endothelial_growth_factor	45,79	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	expression|compound|START_ENTITY Correlation|nmod|expression Correlation|nmod|END_ENTITY	Correlation of p53 and bcl-2 expression with vascular_endothelial_growth_factor -LRB- VEGF -RRB- , microvessel density -LRB- MVD -RRB- and clinico-pathological features in colon_cancer .
15221598	0	p53	30,33	vascular_endothelial_growth_factor	42,76	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation and expression of p53 , HER-2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and e-cadherin in a high-risk breast-cancer population .
21324396	0	p53	0,3	vascular_endothelial_growth_factor	13,47	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|compound|END_ENTITY	p53 inhibits vascular_endothelial_growth_factor expression in solid tumor .
25225463	0	p53	48,51	vascular_endothelial_growth_factor	59,93	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	epidermal|dep|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
26573068	0	p53	67,70	vascular_endothelial_growth_factor	10,44	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	co|compound|START_ENTITY type|dep|co Effect|dep|type Effect|nmod|siRNA siRNA|compound|END_ENTITY	Effect of vascular_endothelial_growth_factor siRNA and wild - type p53 co - expressing plasmid in MDA - MB -231 cells .
8108142	0	p53	7,10	vascular_endothelial_growth_factor	53,87	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	potentiates|nsubj|START_ENTITY potentiates|dobj|induction induction|nmod|expression expression|compound|END_ENTITY	Mutant p53 potentiates protein_kinase_C induction of vascular_endothelial_growth_factor expression .
8521408	0	p53	10,13	vascular_endothelial_growth_factor	59,93	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	influences|nsubj|START_ENTITY influences|nmod|expression expression|compound|END_ENTITY	Wild-type p53 and v-Src exert opposing influences on human vascular_endothelial_growth_factor gene expression .
9377555	0	p53	0,3	vascular_endothelial_growth_factor	58,92	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	repress|nsubj|START_ENTITY repress|dobj|transcription transcription|nmod|gene gene|compound|END_ENTITY	p53 does not repress hypoxia-induced transcription of the vascular_endothelial_growth_factor gene .
9622060	0	p53	30,33	vascular_endothelial_growth_factor	63,97	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	down-regulates|compound|START_ENTITY END_ENTITY|nsubj|down-regulates	Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular_endothelial_growth_factor expression and inhibits angiogenesis in human colon_cancer .
9635853	0	p53	93,96	vascular_endothelial_growth_factor	39,73	p53	vascular endothelial growth factor	7157	7422	Gene	Gene	mutation|compound|START_ENTITY associated|nmod|mutation associated|nsubjpass|END_ENTITY	In oesophageal_squamous_cell_carcinoma vascular_endothelial_growth_factor is associated with p53 mutation , advanced stage and poor prognosis .
25028191	0	p53	92,95	vimentin	14,22	p53	vimentin	7157	7431	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of vimentin and survivin in clear_cell_renal_cell_carcinoma and correlation with p53 .
17716971	0	p53	59,62	vitamin_D_receptor	27,45	p53	vitamin D receptor	7157	7421	Gene	Gene	Family|compound|START_ENTITY END_ENTITY|nmod|Family	Differential regulation of vitamin_D_receptor -LRB- VDR -RRB- by the p53 Family : p73-dependent induction of VDR upon DNA damage .
21556561	0	p53	88,91	waf-1	125,130	p53	waf-1	22060(Tax:10090)	12575(Tax:10090)	Gene	Gene	START_ENTITY|dep|induction induction|nmod|END_ENTITY	Status of the mdm-2 and waf-1 genes in mouse epidermal jb6 variants harboring wild-type p53 - a p53-independent induction of waf-1 .
10347252	0	p53	122,125	waf1	22,26	p53	waf1	7157	1026	Gene	Gene	protein|amod|START_ENTITY lacking|dobj|protein induced|xcomp|lacking arrest|acl|induced decreases|dobj|arrest decreases|nsubj|Overexpression Overexpression|nmod|p21 p21|appos|END_ENTITY	Overexpression of p21 -LRB- waf1 -RRB- decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein .
11237596	0	p53	83,86	waf1	57,61	p53	waf1	7157	1026	Gene	Gene	protein|compound|START_ENTITY containing|nmod|protein containing|dobj|element element|amod|END_ENTITY	Conformation_and_rigidity of DNA microcircles containing waf1 response element for p53 regulatory protein .
22825333	0	p53	86,89	waf1	32,36	p53	waf1	7157	1026	Gene	Gene	tumors|nummod|START_ENTITY protein|nmod|tumors protein|nsubj|regulation regulation|nmod|p21 p21|appos|END_ENTITY	Differential regulation of p21 -LRB- waf1 -RRB- protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications .
24004175	0	p53-binding_protein_1	16,37	53BP1	39,44	p53-binding protein 1	53BP1	7158	7158	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Significance of p53-binding_protein_1 -LRB- 53BP1 -RRB- expression in thyroid_papillary_microcarcinoma : association with BRAFV600E mutation status .
23241165	0	p53-inducible_gene_3	35,55	PIG3	57,61	p53-inducible gene 3	PIG3	9540	9540	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Functional repeats -LRB- TGYCC -RRB- n in the p53-inducible_gene_3 -LRB- PIG3 -RRB- promoter and susceptibility to squamous_cell_carcinoma_of_the_head_and_neck .
19638586	0	p53-reactivating_drugs_nutlin-3_and_RITA	63,103	MDM2	20,24	p53-reactivating drugs nutlin-3 and RITA	MDM2	84934	4193	Gene	Gene	response|nmod|START_ENTITY determines|dobj|response determines|nsubj|regulation regulation|nmod|END_ENTITY	HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating_drugs_nutlin-3_and_RITA .
17712528	0	p53-related_protein_kinase	54,80	Akt/PKB	91,98	p53-related protein kinase	Akt/PKB	112858	207	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of the atypical kinase p53-related_protein_kinase -LRB- PRPK -RRB- by Akt/PKB .
17712528	0	p53-related_protein_kinase	54,80	PRPK	82,86	p53-related protein kinase	PRPK	112858	112858	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation and activation of the atypical kinase p53-related_protein_kinase -LRB- PRPK -RRB- by Akt/PKB .
25312903	0	p53R2	15,20	E2F1	0,4	p53R2	E2F1	50484	1869	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	E2F1 regulates p53R2 gene expression in p53-deficient cells .
19015526	0	p53R2	89,94	MDM2	111,115	p53R2	MDM2	50484	4193	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage .
22520477	0	p53_binding_protein_1	4,25	53BP1	27,32	p53 binding protein 1	53BP1	7158	7158	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Low p53_binding_protein_1 -LRB- 53BP1 -RRB- expression is associated with increased local recurrence in breast_cancer patients treated with breast-conserving surgery and radiotherapy .
20646866	0	p53_binding_protein_1	60,81	TP53BP1	83,90	p53 binding protein 1	TP53BP1	7158	7158	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of single nucleotide polymorphisms -LRB- SNPs -RRB- in the p53_binding_protein_1 -LRB- TP53BP1 -RRB- gene in breast_cancer patients treated with breast-conserving surgery and whole-breast irradiation -LRB- BCS + RT -RRB- .
24388982	0	p53_induced_gene_3	76,94	PIG3	96,100	p53 induced gene 3	PIG3	9540	9540	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Identification of prohibitin and prohibiton as novel factors binding to the p53_induced_gene_3 -LRB- PIG3 -RRB- promoter -LRB- TGYCC -RRB- -LRB- 15 -RRB- motif .
8643668	0	p53bp2	85,91	Src	31,34	p53bp2	Src	7159	6714	Gene	Gene	Crk|appos|START_ENTITY homology|nmod|Crk homology|nsubj|preferences preferences|nmod|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
8643668	0	p53bp2	85,91	Src	59,62	p53bp2	Src	7159	6714	Gene	Gene	Crk|appos|START_ENTITY Crk|compound|END_ENTITY	Distinct ligand preferences of Src homology 3 domains from Src , Yes , Abl , Cortactin , p53bp2 , PLCgamma , Crk , and Grb2 .
12586738	0	p54	4,7	Lyn	44,47	p54	Lyn	3433	4067	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	The p54 cleaved form of the tyrosine kinase Lyn generated by caspases during BCR-induced cell death in B lymphoma acts as a negative regulator of apoptosis .
9023105	0	p54	50,53	Xp54	0,4	p54	Xp54	1656	399080(Tax:8355)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Xp54 , the Xenopus homologue of human RNA helicase p54 , is an integral component of stored mRNP particles in oocytes .
14980493	0	p54	67,70	p30	62,65	p54	p30	3433	201161	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Neutralizing antibodies to African_swine_fever_virus proteins p30 , p54 , and p72 are not sufficient for antibody-mediated protection .
10708710	0	p55	4,7	CD120a	40,46	p55	CD120a	7132	7132	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The p55 tumor necrosis factor receptor -LRB- CD120a -RRB- induces endothelin-1 synthesis in endothelial and epithelial cells .
1370571	0	p55	131,134	IL-2	155,159	p55	IL-2	3559	3558	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	Immunochemical characterization of antigenic domains on human IL-2 : spatially distinct epitopes are associated with binding to the p55 and p70 subunits of IL-2 receptor .
1370571	0	p55	131,134	IL-2	62,66	p55	IL-2	3559	3558	Gene	Gene	subunits|amod|START_ENTITY binding|nmod|subunits receptor|amod|binding associated|nmod|receptor associated|nsubjpass|characterization characterization|nmod|domains domains|nmod|END_ENTITY	Immunochemical characterization of antigenic domains on human IL-2 : spatially distinct epitopes are associated with binding to the p55 and p70 subunits of IL-2 receptor .
1690471	1	p55	126,129	IL-2	91,95	p55	IL-2	3559	3558	Gene	Gene	chain|amod|START_ENTITY Relationships|nmod|chain Relationships|nmod|END_ENTITY	Relationships to high-affinity IL-2 binding and modulation of the p55 chain .
1717581	0	p55	32,35	IL-2	54,58	p55	IL-2	17524(Tax:10090)	16183(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|receptor receptor|compound|END_ENTITY	Structure-function study of the p55 subunit of murine IL-2 receptor by epitope mapping .
2011131	0	p55	19,22	IL-2	65,69	p55	IL-2	17524(Tax:10090)	16183(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY interleukin-2|nsubj|Induction interleukin-2|dobj|expression expression|nmod|END_ENTITY	Induction of mouse p55 interleukin-2 receptor gene expression by IL-2 and IL-4 and characterization of its transcription initiation sites .
2258612	0	p55	79,82	IL-2	107,111	p55	IL-2	21937(Tax:10090)	16183(Tax:10090)	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	IL-2-dependent proliferation of murine T cells requires expression of both the p55 and p70 subunits of the IL-2 receptor .
2469650	0	p55	160,163	IL-2	42,46	p55	IL-2	21937(Tax:10090)	16183(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY determinant|nmod|subunit importance|nmod|determinant Studies|dep|importance Studies|nmod|formation formation|nmod|sites sites|amod|binding binding|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2469650	0	p55	81,84	IL-2	42,46	p55	IL-2	21937(Tax:10090)	16183(Tax:10090)	Gene	Gene	+|nummod|START_ENTITY IL-2_receptor|dep|+ complex|amod|IL-2_receptor sites|nmod|complex sites|amod|binding binding|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2523424	0	p55	69,72	IL-2	14,18	p55	IL-2	21937(Tax:10090)	16183(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY expression|nmod|subunit up-regulates|dobj|expression up-regulates|nsubj|Activation Activation|nmod|END_ENTITY	Activation by IL-2 , but not IL-4 , up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2 - _ and_IL-4-dependent T cell lines .
2523424	0	p55	69,72	IL-2	88,92	p55	IL-2	21937(Tax:10090)	16183(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|receptor receptor|compound|END_ENTITY	Activation by IL-2 , but not IL-4 , up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2 - _ and_IL-4-dependent T cell lines .
2897342	0	p55	54,57	IL-2	38,42	p55	IL-2	3559	3558	Gene	Gene	effects|dep|START_ENTITY effects|nmod|expression expression|nmod|receptors receptors|compound|END_ENTITY	Differential effects on expression of IL-2 receptors -LRB- p55 and p70 -RRB- by the HTLV-I pX DNA .
2971378	0	p55	24,27	IL-2	43,47	p55	IL-2	21937(Tax:10090)	16183(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|receptor receptor|compound|END_ENTITY	Nuclear location of the p55 subunit of the IL-2 receptor following activation of the HT-2 T helper cell line .
2469650	0	p55	160,163	IL-2_receptor	67,80	p55	IL-2 receptor	21937(Tax:10090)	16184(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY determinant|nmod|subunit importance|nmod|determinant Studies|dep|importance Studies|nmod|formation formation|nmod|sites sites|nmod|complex complex|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2469650	0	p55	81,84	IL-2_receptor	67,80	p55	IL-2 receptor	21937(Tax:10090)	16184(Tax:10090)	Gene	Gene	+|nummod|START_ENTITY END_ENTITY|dep|+	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
3143716	0	p55	69,72	IL2	95,98	p55	IL2	3559	3558	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|receptor receptor|compound|END_ENTITY	Interleukin_2 -LRB- IL2 -RRB- PE40 is cytotoxic to cells displaying either the p55 or p70 subunit of the IL2 receptor .
2318250	0	p55	31,34	IL_2	92,96	p55	IL 2	17524(Tax:10090)	16183(Tax:10090)	Gene	Gene	component|amod|START_ENTITY level|nmod|component control|nsubj|level control|dobj|responsiveness responsiveness|nummod|END_ENTITY	Evidence that the level of the p55 component of the interleukin -LRB- IL -RRB- 2 receptor can control IL_2 responsiveness in a murine IL_3-dependent cell .
8516548	0	p55	1,4	IL_2	29,33	p55	IL 2	3559	3558	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	-LSB- p55 and p75 subunits of the IL_2 receptor , membrane bound and soluble , in peripheral lymphocytes in patients with solid tumors -RSB- .
1370410	4	p55	802,805	IL_2R	796,801	p55	IL 2R	3559	3560	Gene	Gene	chain|amod|START_ENTITY chain|compound|END_ENTITY	Incubation with IL_2 alone or irradiated target cells alone could induce expression of the IL_2R p55 chain by both CD56bright and CD56dim NK cells ; a combination of both stimuli was most effective .
15516265	0	p55	85,88	MBD2/3	42,48	p55	MBD2/3	41836(Tax:7227)	41151(Tax:7227)	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	The Drosophila methyl-DNA binding protein MBD2/3 interacts with the NuRD complex via p55 and MI-2 .
8824805	0	p55	53,56	MPP1	63,67	p55	MPP1	4354	4354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Complete genomic organization of the human erythroid p55 gene -LRB- MPP1 -RRB- , a membrane-associated guanylate kinase homologue .
8954807	0	p55	50,53	Mpp1	55,59	p55	Mpp1	17524(Tax:10090)	17524(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	cDNA sequence and genomic structure of the murine p55 -LRB- Mpp1 -RRB- gene .
1382704	0	p55	53,56	TNF	38,41	p55	TNF	7132	7124	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|Involvement Involvement|nmod|factor factor|appos|END_ENTITY	Involvement of tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 in TNF responses of acute_myeloid_leukemia blasts in vitro .
1382704	0	p55	53,56	TNF	68,71	p55	TNF	7132	7124	Gene	Gene	receptors|dobj|START_ENTITY receptors|nmod|responses responses|compound|END_ENTITY	Involvement of tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 in TNF responses of acute_myeloid_leukemia blasts in vitro .
15625085	0	p55	4,7	TNF	30,33	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY mediates|nsubj|receptor mediates|dobj|inhibition inhibition|compound|END_ENTITY	The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis .
15625085	0	p55	4,7	TNF	8,11	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis .
17468886	0	p55	17,20	TNF	21,24	p55	TNF	25625(Tax:10116)	103694380	Gene	Gene	alpha-receptor|amod|START_ENTITY alpha-receptor|compound|END_ENTITY	Up-regulation of p55 TNF alpha-receptor in dorsal root ganglia neurons following lumbar facet_joint_injury in rats .
19582157	0	p55	11,14	TNF	15,18	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Absence of p55 TNF receptor reduces atherosclerosis , but has no major effect on angiotensin II induced aneurysms in LDL_receptor_deficient mice .
22156959	0	p55	39,42	TNF	43,46	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Selective inhibition of intra-alveolar p55 TNF receptor attenuates ventilator-induced lung_injury .
23526821	0	p55	188,191	TNF	184,187	p55	TNF	7132	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like_graft-versus-host_disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor .
7492782	0	p55	201,204	TNF	178,181	p55	TNF	7132	7124	Gene	Gene	factor|dobj|START_ENTITY factor|dep|END_ENTITY	Administration of recombinant human granulocyte-macrophage_colony-stimulating_factor after chemotherapy regulates the expression and secretion of monocyte tumor necrosis factor -LRB- TNF -RRB- and TNF receptors p55 and p75 .
7535144	0	p55	39,42	TNF	51,54	p55	TNF	7132	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	TNF-alpha , the great imitator : role of p55 and p75 TNF receptors in hematopoiesis .
7592709	0	p55	118,121	TNF	114,117	p55	TNF	7132	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Tumor necrosis factor induces lipopolysaccharide tolerance in a human adenocarcinoma cell line mainly through the TNF p55 receptor .
8018924	0	p55	139,142	TNF	143,146	p55	TNF	7132	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Evidence that tumor_necrosis_factor_alpha -LRB- TNF -RRB- - induced activation of neutrophil respiratory burst on biologic surfaces is mediated by the p55 TNF receptor .
8018924	0	p55	139,142	TNF	43,46	p55	TNF	7132	7124	Gene	Gene	receptor|amod|START_ENTITY mediated|nmod|receptor Evidence|parataxis|mediated Evidence|dep|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|appos|END_ENTITY	Evidence that tumor_necrosis_factor_alpha -LRB- TNF -RRB- - induced activation of neutrophil respiratory burst on biologic surfaces is mediated by the p55 TNF receptor .
8145037	0	p55	79,82	TNF	83,86	p55	TNF	7132	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	A human tumor_necrosis_factor -LRB- TNF -RRB- alpha mutant that binds exclusively to the p55 TNF receptor produces toxicity in the baboon .
8381414	0	p55	71,74	TNF	75,78	p55	TNF	7132	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- up-regulates the expression of p75 but not p55 TNF receptors , and both receptors mediate , independently of each other , up-regulation of transforming_growth_factor_alpha and epidermal_growth_factor_receptor mRNA .
8823362	0	p55	35,38	TNF	62,65	p55	TNF	7132	7124	Gene	Gene	factor|amod|START_ENTITY role|nmod|factor Evidence|nmod|role Evidence|appos|END_ENTITY	Evidence for exclusive role of the p55 tumor necrosis factor -LRB- TNF -RRB- receptor in mediating the TNF-induced collagenase expression by human dermal fibroblasts .
8955207	0	p55	13,16	TNF	144,147	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	plays|nsubj|START_ENTITY plays|nmod|injection injection|nmod|END_ENTITY	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF .
9103455	0	p55	30,33	TNF	49,52	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	murine|amod|START_ENTITY shedding|nmod|murine END_ENTITY|nsubj|shedding	Constitutive shedding of both p55 and p75 murine TNF receptors in vivo .
9348317	0	p55	66,69	TNF	45,48	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	TNF_receptors|amod|START_ENTITY mediated|nmod|TNF_receptors mediated|nsubjpass|activity activity|appos|END_ENTITY	Antiviral activity of tumor_necrosis_factor -LRB- TNF -RRB- is mediated via p55 and p75 TNF_receptors .
9407552	0	p55	37,40	TNF	14,17	p55	TNF	25625(Tax:10116)	103694380	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|receptors receptors|compound|END_ENTITY	Expression of TNF and TNF receptors -LRB- p55 and p75 -RRB- in the rat brain after focal cerebral_ischemia .
9551933	0	p55	55,58	TNF	0,3	p55	TNF	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY reveal|dobj|roles reveal|nsubj|mice mice|compound|END_ENTITY	TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation .
10080877	0	p55	144,147	TNF-alpha	111,120	p55	TNF-alpha	7132	7124	Gene	Gene	receptor|amod|START_ENTITY binding|nmod|receptor binding|nsubj|END_ENTITY	Identification of TNF-alpha binding peptides from a D-amino_acid_hexapeptide library that specifically inhibit TNF-alpha binding to recombinant p55 receptor .
10080877	0	p55	144,147	TNF-alpha	18,27	p55	TNF-alpha	7132	7124	Gene	Gene	receptor|amod|START_ENTITY binding|nmod|receptor inhibit|xcomp|binding library|acl:relcl|inhibit peptides|nmod|library peptides|nsubj|Identification Identification|nmod|binding binding|compound|END_ENTITY	Identification of TNF-alpha binding peptides from a D-amino_acid_hexapeptide library that specifically inhibit TNF-alpha binding to recombinant p55 receptor .
10385602	0	p55	46,49	TNF-alpha	90,99	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	p75|dep|START_ENTITY receptors|amod|p75 downregulate|nsubj|receptors downregulate|dobj|activity activity|amod|END_ENTITY	Soluble tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 and interleukin-10 downregulate TNF-alpha activity during the lung response to silica particles in NMRI mice .
10623807	0	p55	4,7	TNF-alpha	8,17	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity .
11137581	0	p55	23,26	TNF-alpha	30,39	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Selective role for the p55 Kd TNF-alpha receptor in immune unresponsiveness induced by an acute viral encephalitis .
11175323	0	p55	15,18	TNF-alpha	22,31	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Absence of the p55 Kd TNF-alpha receptor promotes survival in rabies_virus acute encephalitis .
14593216	0	p55	16,19	TNF-alpha	48,57	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY Upregulation|nmod|receptors Upregulation|acl|mediating mediating|dobj|transport transport|amod|END_ENTITY	Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier .
15514106	0	p55	92,95	TNF-alpha	96,105	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Signaling for myocardial_depression in hemorrhagic_shock : roles of Toll-like_receptor_4 and p55 TNF-alpha receptor .
16495559	0	p55	170,173	TNF-alpha	37,46	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	resistance|nmod|START_ENTITY Role|dep|resistance Role|nmod|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|appos|END_ENTITY	Role of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- and interleukin-10 in the pathogenesis of severe murine monocytotropic ehrlichiosis : increased resistance of TNF receptor p55 - and p75-deficient mice to fatal ehrlichial_infection .
7520777	0	p55	224,227	TNF-alpha	29,38	p55	TNF-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY role|nmod|receptors production|dep|role production|appos|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem_cell_factor and interleukin-7 : novel stimulatory role of p55 TNF receptors .
7535144	0	p55	39,42	TNF-alpha	0,9	p55	TNF-alpha	7132	7124	Gene	Gene	receptors|amod|START_ENTITY role|nmod|receptors END_ENTITY|dep|role	TNF-alpha , the great imitator : role of p55 and p75 TNF receptors in hematopoiesis .
7514902	0	p55	155,158	TNF_alpha	53,62	p55	TNF alpha	3559	7124	Gene	Gene	receptors|amod|START_ENTITY involvement|nmod|receptors effects|dep|involvement effects|nmod|tumor_necrosis_factor_alpha tumor_necrosis_factor_alpha|appos|END_ENTITY	Bifunctional effects of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- on the growth of mature and primitive human hematopoietic progenitor cells : involvement of p55 and p75 TNF receptors .
7522632	0	p55	147,150	TNF_alpha	151,160	p55	TNF alpha	7132	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
7522632	0	p55	147,150	TNF_alpha	29,38	p55	TNF alpha	7132	7124	Gene	Gene	receptors|amod|START_ENTITY cells|nmod|receptors expression|nmod|cells downregulates|dobj|expression downregulates|nsubj|Tumor_necrosis_factor_alpha Tumor_necrosis_factor_alpha|appos|END_ENTITY	Tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- downregulates c-kit proto-oncogene product expression in normal and acute_myeloid_leukemia CD34 + cells via p55 TNF_alpha receptors .
8235292	0	p55	54,57	TNF_alpha	33,42	p55	TNF alpha	7132	7124	Gene	Gene	receptors|dep|START_ENTITY receptors|compound|END_ENTITY	Studies on the expression of the TNF_alpha receptors -LRB- p55 and p75 -RRB- and their relative contributions to prostanoid production and glycolytic rate by rheumatoid synovial fibroblasts in vitro .
9531303	0	p55	37,40	TNF_receptor_type_1	16,35	p55	TNF receptor type 1	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
9531303	0	p55	37,40	TNF_receptor_type_2	54,73	p55	TNF receptor type 2	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
18475579	0	p55	18,21	TNFalpha	67,75	p55	TNFalpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	Chemotaxis|nsubj|START_ENTITY Chemotaxis|nmod|END_ENTITY	The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by TNFalpha and a TNFalpha 36-62 Peptide .
9890556	0	p55	92,95	TNFalpha	96,104	p55	TNFalpha	7132	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Enhancement of the surface expression of tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- but not the p55 TNFalpha receptor in the THP-1 monocytic cell line by matrix metalloprotease inhibitors .
23611870	0	p55	80,83	Tumor_necrosis_factor	0,21	p55	Tumor necrosis factor	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY deletion|nmod|receptor effects|nmod|deletion END_ENTITY|dep|effects	Tumor_necrosis_factor in traumatic_brain_injury : effects of genetic deletion of p55 or p75 receptor .
7504889	0	p55	68,71	Tumor_necrosis_factor	0,21	p55	Tumor necrosis factor	7132	7124	Gene	Gene	receptor|amod|START_ENTITY activates|nmod|receptor activates|nsubj|END_ENTITY	Tumor_necrosis_factor activates human endothelial cells through the p55 tumor_necrosis_factor receptor but the p75 receptor contributes to activation at low tumor_necrosis_factor concentration .
16029216	0	p55	40,43	Tumor_necrosis_factor-alpha	0,27	p55	Tumor necrosis factor-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	knockout|appos|START_ENTITY knockout|compound|receptor receptor|amod|END_ENTITY	Tumor_necrosis_factor-alpha receptor 1 -LRB- p55 -RRB- knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons .
7520777	0	p55	224,227	Tumor_necrosis_factor-alpha	0,27	p55	Tumor necrosis factor-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY role|nmod|receptors production|dep|role production|amod|END_ENTITY	Tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem_cell_factor and interleukin-7 : novel stimulatory role of p55 TNF receptors .
1487324	0	p55	25,28	interleukin-2	29,42	p55	interleukin-2	3559	3558	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Pokeweed mitogen induces p55 interleukin-2 receptor expression on human monocytes and its effect on interleukin-2 activated monocyte cytotoxicity .
1581584	0	p55	27,30	interleukin-2	67,80	p55	interleukin-2	3559	3558	Gene	Gene	expression|amod|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	Phorbol_esters up-regulate p55 and down-regulate p75 expression of interleukin-2 receptors in human T cells .
1691591	0	p55	14,17	interleukin-2	24,37	p55	interleukin-2	3559	3558	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of p55 -LRB- Tac -RRB- interleukin-2 receptor -LRB- IL-2R -RRB- , but not p75 IL-2R , in cultured H-RS cells and H-RS cells in tissues .
2243505	0	p55	39,42	interleukin-2	53,66	p55	interleukin-2	3559	3558	Gene	Gene	chain|appos|START_ENTITY chain|nmod|receptor receptor|compound|END_ENTITY	Intracytoplasmic detection of the Tac -LRB- p55 -RRB- chain of interleukin-2 receptor in pre-B leukemic cells associated with a constitutive expression of Tac mRNA .
2312149	0	p55	45,48	interleukin-2	85,98	p55	interleukin-2	3559	3558	Gene	Gene	chains|amod|START_ENTITY chains|nmod|receptor receptor|compound|END_ENTITY	Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin_A .
2588963	0	p55	86,89	interleukin-2	62,75	p55	interleukin-2	3559	3558	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	1_alpha , _ 25-dihydroxyvitamin_D3 enhances the up-regulation of interleukin-2 receptor -LRB- p55 -RRB- by interleukin-2 .
2588963	0	p55	86,89	interleukin-2	94,107	p55	interleukin-2	3559	3558	Gene	Gene	receptor|appos|START_ENTITY up-regulation|nmod|receptor enhances|dobj|up-regulation enhances|nmod|END_ENTITY	1_alpha , _ 25-dihydroxyvitamin_D3 enhances the up-regulation of interleukin-2 receptor -LRB- p55 -RRB- by interleukin-2 .
2787321	0	p55	119,122	interleukin-2	154,167	p55	interleukin-2	3559	3558	Gene	Gene	component|amod|START_ENTITY component|nmod|receptor receptor|compound|END_ENTITY	Crystallization and preliminary X-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high affinity interleukin-2 receptor .
7522954	0	p55	26,29	interleukin-2	135,148	p55	interleukin-2	3559	3558	Gene	Gene	interleukin-2_receptors|amod|START_ENTITY expression|nmod|interleukin-2_receptors expression|nmod|administration administration|nmod|END_ENTITY	Independent expression of p55 and p75 interleukin-2_receptors -LRB- IL-2R -RRB- during intravenous or subcutaneous administration of recombinant interleukin-2 -LRB- rIL-2 -RRB- by T-lymphocytes and natural killer cells .
8458377	0	p55	68,71	interleukin-2	27,40	p55	interleukin-2	3559	3558	Gene	Gene	alpha|dep|START_ENTITY chain|amod|alpha role|nmod|chain reveals|dobj|role reveals|nsubj|Mutation Mutation|nmod|Asp20 Asp20|nmod|END_ENTITY	Mutation of Asp20 of human interleukin-2 reveals a dual role of the p55 alpha chain of the interleukin-2 receptor .
8458377	0	p55	68,71	interleukin-2	91,104	p55	interleukin-2	3559	3558	Gene	Gene	alpha|dep|START_ENTITY chain|amod|alpha chain|nmod|receptor receptor|compound|END_ENTITY	Mutation of Asp20 of human interleukin-2 reveals a dual role of the p55 alpha chain of the interleukin-2 receptor .
8564714	0	p55	84,87	interleukin-2	61,74	p55	interleukin-2	281861(Tax:9913)	280822(Tax:9913)	Gene	Gene	chain|amod|START_ENTITY chain|compound|END_ENTITY	Interleukin-10 downregulates proliferation and expression of interleukin-2 receptor p55 chain and interferon-gamma , but not interleukin-2 or interleukin-4 , by parasite-specific helper T cell clones obtained from cattle chronically infected with Babesia_bovis or Fasciola_hepatica .
1680935	0	p55	41,44	interleukin-2_receptor	17,39	p55	interleukin-2 receptor	3559	3559	Gene	Gene	Induction|appos|START_ENTITY Induction|nmod|END_ENTITY	Induction of the interleukin-2_receptor -LRB- p55 -RRB- by interferons .
2449607	0	p55	114,117	interleukin-2_receptor	139,161	p55	interleukin-2 receptor	21937(Tax:10090)	16184(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Characterization of three monoclonal antibodies specifically directed against the ligand binding site area of the p55 subunit of the mouse interleukin-2_receptor .
2440696	0	p55	67,70	interleukin_2_receptor	86,108	p55	interleukin 2 receptor	21937(Tax:10090)	16184(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin_2_receptor : relationship to the interleukin 2-binding site .
1581584	0	p55	27,30	p75	49,52	p55	p75	3559	3560	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Phorbol_esters up-regulate p55 and down-regulate p75 expression of interleukin-2 receptors in human T cells .
2469650	0	p55	160,163	p75	87,90	p55	p75	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY determinant|nmod|subunit importance|nmod|determinant Studies|dep|importance Studies|nmod|formation formation|nmod|sites sites|nmod|complex complex|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2469650	0	p55	81,84	p75	87,90	p55	p75	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	+|nummod|START_ENTITY IL-2_receptor|dep|+ complex|amod|IL-2_receptor complex|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
7836916	0	p55	42,45	p75	130,133	p55	p75	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	specific|nmod|START_ENTITY receptors|amod|specific antibodies|dep|receptors antibodies|dep|identification identification|nmod|novel novel|nmod|role role|nmod|END_ENTITY	Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors : identification of a novel in vivo role for p75 .
9531303	0	p55	37,40	p75	75,78	p55	p75	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|TNF_receptor_type_2 TNF_receptor_type_2|appos|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
9712914	0	p55	65,68	p75	82,85	p55	p75	21937(Tax:10090)	21938(Tax:10090)	Gene	Gene	CD120a|appos|START_ENTITY CD120a|appos|END_ENTITY	Cooperative signaling by tumor necrosis factor receptors CD120a -LRB- p55 -RRB- and CD120b -LRB- p75 -RRB- in the expression of nitric_oxide and inducible nitric_oxide synthase by mouse macrophages .
10501470	0	p55	144,147	tumor_necrosis_factor	111,132	p55	tumor necrosis factor	25625(Tax:10116)	103694380	Gene	Gene	receptors|dep|START_ENTITY receptors|compound|END_ENTITY	Effects of circulating tumor_necrosis_factor on the neuronal activity and expression of the genes encoding the tumor_necrosis_factor receptors -LRB- p55 and p75 -RRB- in the rat brain : a view from the blood-brain barrier .
10501470	0	p55	144,147	tumor_necrosis_factor	23,44	p55	tumor necrosis factor	25625(Tax:10116)	103694380	Gene	Gene	receptors|dep|START_ENTITY encoding|dobj|receptors genes|acl|encoding activity|nmod|genes circulating|nmod|activity circulating|dobj|END_ENTITY	Effects of circulating tumor_necrosis_factor on the neuronal activity and expression of the genes encoding the tumor_necrosis_factor receptors -LRB- p55 and p75 -RRB- in the rat brain : a view from the blood-brain barrier .
11078604	0	p55	20,23	tumor_necrosis_factor	32,53	p55	tumor necrosis factor	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Divergent roles for p55 and p75 tumor_necrosis_factor receptors in the pathogenesis of MOG -LRB- 35-55 -RRB- - induced experimental_autoimmune_encephalomyelitis .
21594476	0	p55	61,64	tumor_necrosis_factor	38,59	p55	tumor necrosis factor	7132	7124	Gene	Gene	levels|dep|START_ENTITY levels|nmod|receptors receptors|nmod|END_ENTITY	Serum levels of soluble receptors for tumor_necrosis_factor -LRB- p55 and p75 sTNFr -RRB- in patients with cervical_cancer .
24856420	0	p55	41,44	tumor_necrosis_factor	10,31	p55	tumor necrosis factor	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Impact of tumor_necrosis_factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania -LRB- Leishmania -RRB- amazonensis .
7504889	0	p55	68,71	tumor_necrosis_factor	72,93	p55	tumor necrosis factor	7132	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Tumor_necrosis_factor activates human endothelial cells through the p55 tumor_necrosis_factor receptor but the p75 receptor contributes to activation at low tumor_necrosis_factor concentration .
8920779	0	p55	61,64	tumor_necrosis_factor	38,59	p55	tumor necrosis factor	7132	7124	Gene	Gene	levels|dep|START_ENTITY levels|nmod|receptors receptors|nmod|END_ENTITY	Serum levels of soluble receptors for tumor_necrosis_factor -LRB- p55 and p75 sTNFr -RRB- in endometrial_cancer .
9348317	0	p55	66,69	tumor_necrosis_factor	22,43	p55	tumor necrosis factor	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	TNF_receptors|amod|START_ENTITY mediated|nmod|TNF_receptors mediated|nsubjpass|activity activity|nmod|END_ENTITY	Antiviral activity of tumor_necrosis_factor -LRB- TNF -RRB- is mediated via p55 and p75 TNF_receptors .
15249730	0	p55	192,195	tumor_necrosis_factor-alpha	164,191	p55	tumor necrosis factor-alpha	21937(Tax:10090)	21926(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Corticosterone changes in response to stressors , acute and protracted actions of tumor_necrosis_factor-alpha , and lipopolysaccharide treatments in mice lacking the tumor_necrosis_factor-alpha p55 receptor gene .
9881743	0	p55	52,55	tumor_necrosis_factor-alpha	7,34	p55	tumor necrosis factor-alpha	7132	7124	Gene	Gene	concentrations|amod|START_ENTITY receptor|dep|concentrations receptor|amod|END_ENTITY	Plasma tumor_necrosis_factor-alpha soluble receptor p55 -LRB- sTNFp55 -RRB- concentrations in eclamptic , preeclamptic and normotensive pregnant Zimbabwean women .
14644624	0	p55	42,45	tumor_necrosis_factor_receptor_1	8,40	p55	tumor necrosis factor receptor 1	21937(Tax:10090)	21937(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of tumor_necrosis_factor_receptor_1 -LRB- p55 -RRB- in hepatocyte proliferation during acetaminophen-induced toxicity in mice .
11420663	0	p55Cdc	47,53	cdc2	62,66	p55Cdc	cdc2	991	983	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Transcriptional upregulation and activation of p55Cdc via p34 -LRB- cdc2 -RRB- in Taxol-induced apoptosis .
17372985	0	p55cdc	30,36	cdc20	23,28	p55cdc	cdc20	107995(Tax:10090)	107995(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of neuronal cdc20 -LRB- p55cdc -RRB- expression by the plasticity-related transcription factor zif268 .
9830036	0	p56	33,36	CD4	45,48	p56	CD4	8999	920	Gene	Gene	lck|amod|START_ENTITY lck|nmod|END_ENTITY	Zinc is essential for binding of p56 -LRB- lck -RRB- to CD4 and CD8alpha .
9266843	0	p56	53,56	Interleukin-18	0,14	p56	Interleukin-18	15957(Tax:10090)	16173(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Interleukin-18 induces activation and association of p56 -LRB- lck -RRB- and MAPK in a murine TH1 clone .
10330160	0	p56	18,21	Lck	22,25	p56	Lck	15957(Tax:10090)	16818(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Expression of the p56 -LRB- Lck -RRB- Y505F mutation in CD45-deficient mice rescues thymocyte development .
19046675	0	p56	101,104	Lck	105,108	p56	Lck	8999	3932	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Validated quantitative structure-activity relationship analysis of a series of 2-aminothiazole based p56 -LRB- Lck -RRB- inhibitors .
11257449	0	p56	33,36	Pyk2	14,18	p56	Pyk2	8999	2185	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of Pyk2 expression by p56 -LRB- Lck -RRB- in Jurkat T lymphocytes .
10082765	0	p56	27,30	lck	31,34	p56	lck	15957(Tax:10090)	16818(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of T lymphocyte p56 -LRB- lck -RRB- , a zinc-finger signal transduction protein , is elevated by dietary_zinc_deficiency and diet restriction in mice .
10225948	0	p56	64,67	lck	68,71	p56	lck	8999	3932	Gene	Gene	Trafficking|dep|START_ENTITY Trafficking|appos|END_ENTITY	Trafficking of an acylated cytosolic protein : newly synthesized p56 -LRB- lck -RRB- travels to the plasma membrane via the exocytic pathway .
10671221	0	p56	14,17	lck	30,33	p56	lck	8999	3932	Gene	Gene	lck|amod|START_ENTITY lck|nmod|END_ENTITY	Conversion of p56 -LRB- lck -RRB- to p60 -LRB- lck -RRB- in human peripheral blood T lymphocytes is dependent on co - stimulation through accessory receptors : involvement of phospholipase C , protein kinase C and MAP-kinases in vivo .
11180123	0	p56	104,107	lck	108,111	p56	lck	8999	3932	Gene	Gene	form|amod|START_ENTITY form|appos|END_ENTITY	The cytoskeleton-associated TCR zeta chain is constitutively phosphorylated in the absence of an active p56 -LRB- lck -RRB- form .
11533187	0	p56	18,21	lck	22,25	p56	lck	8999	3932	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Downregulation of p56 -LRB- lck -RRB- tyrosine kinase activity in T cells of squirrel monkeys -LRB- Saimiri_sciureus -RRB- correlates with the nontransforming and apathogenic properties of herpesvirus_saimiri in its natural host .
12614879	0	p56	88,91	lck	92,95	p56	lck	8999	3932	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Role of solution conformation and flexibility of short peptide ligands that bind to the p56 -LRB- lck -RRB- SH2 domain .
12798323	0	p56	102,105	lck	106,109	p56	lck	8999	3932	Gene	Gene	BMS-243117|compound|START_ENTITY BMS-243117|appos|END_ENTITY	Molecular design , synthesis , and structure-Activity relationships leading to the potent and selective p56 -LRB- lck -RRB- inhibitor BMS-243117 .
19325836	0	p56	14,17	lck	18,21	p56	lck	8999	3932	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	QSAR study of p56 -LRB- lck -RRB- protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS .
8910285	0	p56	2,5	lck	6,9	p56	lck	8999	3932	Gene	Gene	ligand|amod|START_ENTITY ligand|compound|END_ENTITY	A p56 -LRB- lck -RRB- ligand serves as a coactivator of an orphan nuclear hormone receptor .
9040011	0	p56	11,14	lck	15,18	p56	lck	15957(Tax:10090)	16818(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Targets of p56 -LRB- lck -RRB- activity in immature thymoblasts : stimulation of the Ras/Raf/MAPK pathway .
9144550	0	p56	14,17	lck	18,21	p56	lck	8999	3932	Gene	Gene	turnover|amod|START_ENTITY turnover|compound|END_ENTITY	Regulation of p56 -LRB- lck -RRB- messenger turnover upon T cell activation : involvement of the 3 ' untranslated region in stability as determined in cell-free extracts .
8630073	0	p56LCK	47,53	Hematopoietic_cell_phosphatase	0,30	p56LCK	Hematopoietic cell phosphatase	3932	5777	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Hematopoietic_cell_phosphatase -LRB- HCP -RRB- regulates p56LCK phosphorylation and ZAP-70 binding to T_cell_receptor_zeta_chain .
10744646	0	p56Lck	10,16	CD4	75,78	p56Lck	CD4	3932	920	Gene	Gene	activity|amod|START_ENTITY Defective|dobj|activity Defective|nmod|patient patient|nmod|lymphocytopenia lymphocytopenia|compound|END_ENTITY	Defective p56Lck activity in T cells from an adult patient with idiopathic CD4 + lymphocytopenia .
10843386	0	p56Lck	26,32	CD4	100,103	p56Lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	transgene|amod|START_ENTITY expression|nmod|transgene reveals|nsubj|expression reveals|nmod|differentiation differentiation|nmod|thymocytes thymocytes|compound|END_ENTITY	Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes .
11854499	0	p56Lck	0,6	CD4	15,18	p56Lck	CD4	3932	920	Gene	Gene	anchors|amod|START_ENTITY END_ENTITY|nsubj|anchors	p56Lck anchors CD4 to distinct microdomains on microvilli .
8478617	0	p56lck	39,45	CD16	67,71	p56lck	CD16	16818(Tax:10090)	14131(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Physical and functional association of p56lck with Fc_gamma_RIIIA -LRB- CD16 -RRB- in natural killer cells .
1358625	1	p56lck	165,171	CD2	96,99	p56lck	CD2	3932	914	Gene	Gene	activation|nmod|START_ENTITY mediate|dobj|activation mediate|nsubj|END_ENTITY	CD2 can mediate TcR-CD3-independent and CD45-dependent activation of p56lck .
10383941	0	p56lck	23,29	CD4	64,67	p56lck	CD4	3932	920	Gene	Gene	signaling|nmod|START_ENTITY CD44|acl|signaling involves|nsubj|CD44 involves|nmod|END_ENTITY	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
10383941	0	p56lck	23,29	CD4	77,80	p56lck	CD4	3932	920	Gene	Gene	signaling|nmod|START_ENTITY CD44|acl|signaling involves|nsubj|CD44 involves|nmod|CD4 CD4|nmod|cells cells|compound|END_ENTITY	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
11086073	0	p56lck	86,92	CD4	63,66	p56lck	CD4	3932	920	Gene	Gene	activity|amod|START_ENTITY independent|nmod|activity independent|nsubj|Desensitization Desensitization|acl|mediated mediated|nmod|END_ENTITY	Desensitization of CXC_chemokine_receptor_4 , mediated by IL-16 / CD4 , is independent of p56lck enzymatic activity .
11160274	0	p56lck	10,16	CD4	44,47	p56lck	CD4	3932	920	Gene	Gene	directs|nsubj|START_ENTITY directs|dobj|maturation maturation|nmod|END_ENTITY	Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes .
11694532	0	p56lck	102,108	CD4	47,50	p56lck	CD4	3932	920	Gene	Gene	kinase|amod|START_ENTITY pools|nmod|kinase actions|nmod|pools regulates|dobj|actions regulates|nsubj|association association|nmod|isoforms isoforms|nmod|END_ENTITY	Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T_cell_antigen_receptor signal transduction .
1280163	0	p56lck	47,53	CD4	100,103	p56lck	CD4	3932	920	Gene	Gene	lymphocyte-specific_protein_tyrosine_kinase|appos|START_ENTITY regulates|nsubj|lymphocyte-specific_protein_tyrosine_kinase regulates|dobj|internalization internalization|nmod|END_ENTITY	A lymphocyte-specific_protein_tyrosine_kinase , p56lck , regulates the PMA-induced internalization of CD4 .
1373141	0	p56lck	28,34	CD4	44,47	p56lck	CD4	3932	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|endocytosis endocytosis|nummod|END_ENTITY	The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits .
1373141	0	p56lck	28,34	CD4	83,86	p56lck	CD4	3932	920	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|advcl|preventing preventing|dobj|entry entry|nmod|END_ENTITY	The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits .
1532002	0	p56lck	0,6	CD4	24,27	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	association|amod|START_ENTITY association|nmod|END_ENTITY	p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation .
1532002	0	p56lck	0,6	CD4	68,71	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	association|amod|START_ENTITY required|nsubjpass|association required|nmod|interaction interaction|nmod|END_ENTITY	p56lck association with CD4 is required for the interaction between CD4 and the TCR/CD3 complex and for optimal antigen stimulation .
1535787	0	p56lck	96,102	CD4	66,69	p56lck	CD4	3932	920	Gene	Gene	autophosphorylation|amod|START_ENTITY increases|dobj|autophosphorylation increases|nsubj|Interaction Interaction|nmod|human_immunodeficiency_virus human_immunodeficiency_virus|acl|glycoprotein glycoprotein|nmod|END_ENTITY	Interaction of human_immunodeficiency_virus glycoprotein 160 with CD4 in Jurkat cells increases p56lck autophosphorylation and kinase activity .
1900242	0	p56lck	91,97	CD4	6,9	p56lck	CD4	3932	920	Gene	Gene	kinase|nmod|START_ENTITY interact|nmod|kinase interact|nsubj|END_ENTITY	Avian CD4 and CD8 interact with a cellular tyrosine protein kinase homologous to mammalian p56lck .
2040625	0	p56lck	108,114	CD4	120,123	p56lck	CD4	3932	920	Gene	Gene	tyrosine|dobj|START_ENTITY tyrosine|nmod|END_ENTITY	Effect of human_immunodeficiency_virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes .
2107025	0	p56lck	63,69	CD4	98,101	p56lck	CD4	3932	920	Gene	Gene	START_ENTITY|nmod|domains domains|nmod|END_ENTITY	Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs .
2109184	0	p56lck	118,124	CD4	54,57	p56lck	CD4	3932	920	Gene	Gene	kinase|amod|START_ENTITY domain|nmod|kinase binding|nmod|domain mediate|xcomp|binding mediate|nsubj|sequences sequences|nmod|domains domains|nmod|END_ENTITY	Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase .
2141630	0	p56lck	84,90	CD4	23,26	p56lck	CD4	3932	920	Gene	Gene	activity|nmod|START_ENTITY alters|dobj|activity alters|nsubj|CD45 CD45|nmod|END_ENTITY	Coclustering CD45 with CD4 or CD8 alters the phosphorylation and kinase activity of p56lck .
2250907	0	p56lck	43,49	CD4	4,7	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	associated|dobj|START_ENTITY END_ENTITY|acl|associated	The CD4 associated tyrosine protein kinase p56lck is positively regulated through its site of autophosphorylation .
2369920	0	p56lck	118,124	CD4	26,29	p56lck	CD4	3932	920	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|domain domain|nmod|END_ENTITY	The cytoplasmic domain of CD4 is required for stable association with the lymphocyte-specific tyrosine protein kinase p56lck .
2470098	0	p56lck	67,73	CD4	4,7	p56lck	CD4	3932	920	Gene	Gene	kinase|appos|START_ENTITY coupled|nmod|kinase coupled|nsubjpass|antigens antigens|compound|END_ENTITY	The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase -LRB- p56lck -RRB- that phosphorylates the CD3 complex .
2787934	0	p56lck	77,83	CD4	54,57	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	induce|nmod|START_ENTITY induce|dobj|dissociation dissociation|nmod|END_ENTITY	Activators of protein kinase C induce dissociation of CD4 , but not CD8 , from p56lck .
3262426	0	p56lck	106,112	CD4	4,7	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck .
7522245	0	p56lck	30,36	CD4	18,21	p56lck	CD4	3932	920	Gene	Gene	activation|amod|START_ENTITY induces|dobj|activation induces|nsubj|ligation ligation|nmod|END_ENTITY	gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation .
7680610	0	p56lck	89,95	CD4	105,108	p56lck	CD4	3932	920	Gene	Gene	START_ENTITY|nmod|lymphocytes lymphocytes|compound|END_ENTITY	Human_immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes .
7737294	0	p56lck	42,48	CD4	71,74	p56lck	CD4	3932	920	Gene	Gene	kinases|dobj|START_ENTITY kinases|nmod|END_ENTITY	Interactions between the tyrosine kinases p56lck , p59fyn and p50csk in CD4 signaling in T cells .
7902564	0	p56lck	125,131	CD4	89,92	p56lck	CD4	3932	920	Gene	Gene	kinase|amod|START_ENTITY activate|dobj|kinase ability|dep|activate reduces|dobj|ability reduces|nsubj|overexpression overexpression|nmod|END_ENTITY	Decreased signaling competence as a result of receptor overexpression : overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4 + CD8 + thymocytes .
7964457	0	p56lck	28,34	CD4	71,74	p56lck	CD4	3932	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|adhesion adhesion|acl|mediated mediated|nmod|proteins proteins|compound|END_ENTITY	The protein tyrosine kinase p56lck regulates cell adhesion mediated by CD4 and major histocompatibility complex class II proteins .
8095557	0	p56lck	4,10	CD4	0,3	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	association|amod|START_ENTITY END_ENTITY|dep|association	CD4 : p56lck association studied in vivo using antibody-induced capping and double indirect immunofluorescence microscopy .
8195720	0	p56lck	85,91	CD4	81,84	p56lck	CD4	3932	920	Gene	Gene	association|amod|START_ENTITY association|compound|END_ENTITY	CD4-mediated enhancement or inhibition of T cell activation does not require the CD4 : p56lck association .
8228817	0	p56lck	76,82	CD4	136,139	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY thymocytes|nmod|kinase thymocytes|parataxis|signaling signaling|nmod|END_ENTITY	Regulation of T cell receptor expression in immature CD4 + CD8 + thymocytes by p56lck tyrosine kinase : basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules .
8228817	0	p56lck	76,82	CD4	53,56	p56lck	CD4	16818(Tax:10090)	12504(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY thymocytes|nmod|kinase thymocytes|nsubj|Regulation Regulation|nmod|expression expression|nmod|+ +|compound|END_ENTITY	Regulation of T cell receptor expression in immature CD4 + CD8 + thymocytes by p56lck tyrosine kinase : basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules .
8376930	0	p56lck	95,101	CD4	40,43	p56lck	CD4	3932	920	Gene	Gene	dissociation|nmod|START_ENTITY involving|dobj|dissociation process|acl|involving process|nsubj|downregulation downregulation|nmod|END_ENTITY	Phorbol_ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck , increased association with clathrin-coated pits , and altered endosomal sorting .
8391060	0	p56lck	28,34	CD4	105,108	p56lck	CD4	3932	920	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|development development|nmod|-RSB- -RSB-|amod|interaction interaction|nmod|coreceptors coreceptors|compound|END_ENTITY	The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors -LSB- corrected -RSB- .
8551242	0	p56lck	111,117	CD4	102,105	p56lck	CD4	3932	920	Gene	Gene	accelerated|nmod|START_ENTITY accelerated|nmod|interaction interaction|nmod|END_ENTITY	HIV-induced apoptosis requires the CD4_receptor cytoplasmic tail and is accelerated by interaction of CD4 with p56lck .
8630734	0	p56lck	128,134	CD4	39,42	p56lck	CD4	3932	920	Gene	Gene	diminish|dobj|START_ENTITY consequence|acl:relcl|diminish impaired|nmod|consequence impaired|nmod|thymocytes thymocytes|compound|END_ENTITY	TCR activation of ZAP70 is impaired in CD4 + CD8 + thymocytes as a consequence of intrathymic interactions that diminish available p56lck .
9317140	0	p56lck	101,107	CD4	51,54	p56lck	CD4	3932	920	Gene	Gene	levels|amod|START_ENTITY affecting|dobj|levels induces|advcl|affecting induces|dobj|down-regulation down-regulation|nmod|antigen antigen|nummod|END_ENTITY	Human_herpesvirus_7 induces the down-regulation of CD4 antigen in lymphoid T cells without affecting p56lck levels .
9842906	0	p56lck	8,14	CD4	42,45	p56lck	CD4	3932	920	Gene	Gene	expression|amod|START_ENTITY Lack|nmod|expression correlates|nsubj|Lack correlates|nmod|endocytosis endocytosis|nummod|END_ENTITY	Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells .
10383941	0	p56lck	23,29	CD44	0,4	p56lck	CD44	3932	960	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	CD44 signaling through p56lck involves lateral association with CD4 in human CD4 + T cells .
8630734	0	p56lck	128,134	CD8	43,46	p56lck	CD8	3932	925	Gene	Gene	diminish|dobj|START_ENTITY consequence|acl:relcl|diminish impaired|nmod|consequence impaired|nmod|thymocytes thymocytes|compound|END_ENTITY	TCR activation of ZAP70 is impaired in CD4 + CD8 + thymocytes as a consequence of intrathymic interactions that diminish available p56lck .
8353285	0	p56lck	137,143	NF-kappa_B	39,49	p56lck	NF-kappa B	3932	4790	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Reactive oxygen intermediates activate NF-kappa_B in a tyrosine kinase-dependent mechanism and in combination with vanadate activate the p56lck and p59fyn tyrosine kinases in human lymphocytes .
12424250	0	p56lck	58,64	P2X7_receptor	18,31	p56lck	P2X7 receptor	3932	5027	Gene	Gene	Signaling|nsubj|START_ENTITY Signaling|nmod|END_ENTITY	Signaling through P2X7_receptor in human T cells involves p56lck , MAP kinases , and transcription factors AP-1 and NF-kappa_B .
1570157	0	p56lck	88,94	SH2	116,119	p56lck	SH2	16818(Tax:10090)	100125854(Tax:10090)	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Regulation of the enzymatic function of the lymphocyte-specific tyrosine protein kinase p56lck by the non-catalytic SH2 and SH3 domains .
20007709	0	p56lck	64,70	SOCS-6	0,6	p56lck	SOCS-6	3932	9306	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation .
7547689	0	p56lck	28,34	TCR	45,48	p56lck	TCR	16818(Tax:10090)	328483(Tax:10090)	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	The protein tyrosine kinase p56lck regulates TCR expression and T cell selection .
8104794	0	p56lck	48,54	Thy-1	123,128	p56lck	Thy-1	313050(Tax:10116)	24832(Tax:10116)	Gene	Gene	kinases|dobj|START_ENTITY kinases|nmod|END_ENTITY	The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl_phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation .
7680610	0	p56lck	89,95	gp120	29,34	p56lck	gp120	3932	3700	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Human_immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56lck in human CD4 T lymphocytes .
8473282	0	p56lck	86,92	interleukin-2	60,73	p56lck	interleukin-2	3932	3558	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Calcium-dependent cyclosporin_A-sensitive activation of the interleukin-2 promoter by p56lck .
1639064	0	p56lck	48,54	p50csk	10,16	p56lck	p50csk	3932	1445	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|kinase kinase|amod|END_ENTITY	The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity .
8557695	0	p56lck	38,44	tip	76,79	p56lck	tip	3932	10524	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Selective activation of T cell kinase p56lck by Herpesvirus_saimiri protein tip .
23421998	0	p57	14,17	Akt	45,48	p57	Akt	1028	207	Gene	Gene	downregulated|nsubjpass|START_ENTITY downregulated|nmod|END_ENTITY	CDK inhibitor p57 -LRB- Kip2 -RRB- is downregulated by Akt during HER2-mediated tumorigenicity .
23187808	0	p57	14,17	COP9_signalosome_subunit_6	52,78	p57	COP9 signalosome subunit 6	1028	10980	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	CDK inhibitor p57 -LRB- Kip2 -RRB- is negatively regulated by COP9_signalosome_subunit_6 .
26988311	0	p57	50,53	Cdkn1c	61,67	p57	Cdkn1c	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The developmental expression of the CDK inhibitor p57 -LRB- kip2 -RRB- -LRB- Cdkn1c -RRB- in the early mouse placenta .
19340297	0	p57	8,11	EZH2	35,39	p57	EZH2	1028	2146	Gene	Gene	CDKN1C|appos|START_ENTITY target|nsubj|CDKN1C target|nmod|END_ENTITY	CDKN1C -LRB- p57 -RRB- is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast_cancer cells .
21205084	0	p57	29,32	EZH2	0,4	p57	EZH2	12721(Tax:10090)	14056(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	EZH2 regulates expression of p57 and contributes to progression of ovarian_cancer in vitro and in vivo .
10446277	0	p57	35,38	KIP2	39,43	p57	KIP2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Spatial and temporal expression of p57 -LRB- KIP2 -RRB- during murine lens development .
10944603	0	p57	24,27	KIP2	28,32	p57	KIP2	1028	1028	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Decreased expression of p57 -LRB- KIP2 -RRB- mRNA in human bladder_cancer .
11891335	0	p57	13,16	KIP2	17,21	p57	KIP2	1028	1028	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of p57 -LRB- KIP2 -RRB- expression by p73beta .
12239171	0	p57	28,31	KIP2	32,36	p57	KIP2	1028	1028	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aberrant DNA methylation of p57 -LRB- KIP2 -RRB- gene in the promoter region in lymphoid malignancies of B-cell phenotype .
15279631	0	p57	0,3	KIP2	4,8	p57	KIP2	1028	1028	Gene	Gene	staining|amod|START_ENTITY staining|compound|END_ENTITY	p57 -LRB- KIP2 -RRB- immunohistochemical staining of gestational_trophoblastic_tumours does not identify the type of the causative pregnancy .
20626178	0	p57	53,56	KIP2	57,61	p57	KIP2	1028	1028	Gene	Gene	expression|dep|START_ENTITY expression|appos|END_ENTITY	Simultaneous detection of imprinted gene expression -LRB- p57 -LRB- KIP2 -RRB- -RRB- and molecular cytogenetics -LRB- FICTION -RRB- in the evaluation of molar_pregnancies .
9858559	0	p57	42,45	KIP2	46,50	p57	KIP2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Cyclin D - and E-dependent kinases and the p57 -LRB- KIP2 -RRB- inhibitor : cooperative interactions in vivo .
10708569	0	p57	28,31	Kip2	32,36	p57	Kip2	246060(Tax:10116)	246060(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible involvement of the p57 -LRB- Kip2 -RRB- gene in bone metabolism .
12176039	0	p57	44,47	Kip2	48,52	p57	Kip2	1028	1028	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	A pro-apoptotic effect of the CDK inhibitor p57 -LRB- Kip2 -RRB- on staurosporine-induced apoptosis in HeLa cells .
12482580	0	p57	75,78	Kip2	79,83	p57	Kip2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of vascular_endothelial_growth_factor in placentas of p57 -LRB- Kip2 -RRB- null embryos .
17112701	0	p57	22,25	Kip2	26,30	p57	Kip2	1028	1028	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	BMP2 and BMP6 control p57 -LRB- Kip2 -RRB- expression and cell growth arrest/terminal differentiation in normal primary human epidermal keratinocytes .
17553990	0	p57	19,22	Kip2	23,27	p57	Kip2	1028	1028	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A crucial role for p57 -LRB- Kip2 -RRB- in the intracellular timer that controls oligodendrocyte differentiation .
26165599	0	p57	31,34	Kip2	77,81	p57	Kip2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY deficiency|nmod|mice occurs|nsubj|deficiency occurs|nmod|manner manner|appos|END_ENTITY	Liver maturation deficiency in p57 -LRB- Kip2 -RRB- - / - mice occurs in a hepatocytic p57 -LRB- Kip2 -RRB- expression-independent manner .
26165599	0	p57	73,76	Kip2	35,39	p57	Kip2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	manner|amod|START_ENTITY occurs|nmod|manner occurs|nsubj|deficiency deficiency|nmod|mice mice|amod|p57 p57|dep|END_ENTITY	Liver maturation deficiency in p57 -LRB- Kip2 -RRB- - / - mice occurs in a hepatocytic p57 -LRB- Kip2 -RRB- expression-independent manner .
26165599	0	p57	73,76	Kip2	77,81	p57	Kip2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	manner|amod|START_ENTITY manner|appos|END_ENTITY	Liver maturation deficiency in p57 -LRB- Kip2 -RRB- - / - mice occurs in a hepatocytic p57 -LRB- Kip2 -RRB- expression-independent manner .
26309408	0	p57	14,17	Kip2	18,22	p57	Kip2	1028	1028	Gene	Gene	Expression|compound|START_ENTITY Expression|appos|END_ENTITY	High Skp2/Low p57 -LRB- Kip2 -RRB- Expression is Associated with Poor Prognosis in Human Breast_Carcinoma .
27015986	0	p57	0,3	Kip2	4,8	p57	Kip2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	p57 -LRB- Kip2 -RRB- knock-in mouse reveals CDK-independent contribution in the development of Beckwith-Wiedemann_syndrome .
14671317	0	p57	0,3	Nurr1	26,31	p57	Nurr1	12721(Tax:10090)	18227(Tax:10090)	Gene	Gene	cooperates|nsubj|START_ENTITY cooperates|nmod|END_ENTITY	p57 -LRB- Kip2 -RRB- cooperates with Nurr1 in developing dopamine cells .
23873832	0	p57	71,74	P21-activated_kinase_4	0,22	p57	P21-activated kinase 4	1028	10298	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	P21-activated_kinase_4 regulates the cyclin-dependent kinase inhibitor p57 -LRB- kip2 -RRB- in human breast_cancer .
15124025	0	p57	38,41	PTHrP	82,87	p57	PTHrP	12721(Tax:10090)	19227(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|actions actions|nmod|END_ENTITY	The cyclin-dependent kinase inhibitor p57 -LRB- Kip2 -RRB- mediates proliferative actions of PTHrP in chondrocytes .
18513743	0	p57	14,17	Sp1	69,72	p57	Sp1	1028	6667	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|role role|nmod|END_ENTITY	Regulation of p57 -LRB- KIP2 -RRB- during muscle differentiation : role of Egr1 , Sp1 and DNA hypomethylation .
16618659	0	p57	0,3	kip2	4,8	p57	kip2	1028	1028	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p57 -LRB- kip2 -RRB- expression is related to carcinogenesis and tumor progression in laryngeal tissues .
25807810	0	p57	15,18	kip2	19,23	p57	kip2	1028	1028	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of p57 -LRB- kip2 -RRB- gene in placenta tissue of patients with pre-eclampsia -RSB- .
26988311	0	p57	50,53	kip2	54,58	p57	kip2	12721(Tax:10090)	12577(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The developmental expression of the CDK inhibitor p57 -LRB- kip2 -RRB- -LRB- Cdkn1c -RRB- in the early mouse placenta .
12482580	0	p57	75,78	vascular_endothelial_growth_factor	24,58	p57	vascular endothelial growth factor	12721(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of vascular_endothelial_growth_factor in placentas of p57 -LRB- Kip2 -RRB- null embryos .
14530263	0	p57Kip2	0,7	LIM-kinase_1	62,74	p57Kip2	LIM-kinase 1	12577(Tax:10090)	16885(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	p57Kip2 regulates actin dynamics by binding and translocating LIM-kinase_1 to the nucleus .
25216674	0	p57Kip2	21,28	MicroRNA-21	0,11	p57Kip2	MicroRNA-21	1028	406991	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MicroRNA-21 inhibits p57Kip2 expression in prostate_cancer .
15254975	0	p57Kip2	31,38	MyoD	0,4	p57Kip2	MyoD	1028	4654	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	MyoD induces the expression of p57Kip2 in cells lacking p21Cip1/Waf1 : overlapping and distinct functions of the two cdk inhibitors .
16405903	0	p57Kip2	0,7	MyoD	22,26	p57Kip2	MyoD	1028	4654	Gene	Gene	induced|nsubjpass|START_ENTITY induced|nmod|END_ENTITY	p57Kip2 is induced by MyoD through a p73-dependent pathway .
22541097	0	p57kip2	15,22	CXCR4	105,110	p57kip2	CXCR4	1028	7852	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|-RSB- -RSB-|nsubj|axis axis|compound|END_ENTITY	-LSB- Expression of p57kip2 in patients with de novo myelodysplastic_syndrome and its relationship with SDF-1 / CXCR4 axis -RSB- .
22740650	0	p57kip2	15,22	MyoD	0,4	p57kip2	MyoD	1028	4654	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure .
22541097	0	p57kip2	15,22	SDF-1	99,104	p57kip2	SDF-1	1028	6387	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	-LSB- Expression of p57kip2 in patients with de novo myelodysplastic_syndrome and its relationship with SDF-1 / CXCR4 axis -RSB- .
15792358	0	p58	36,39	CDK11	30,35	p58	CDK11	12537(Tax:10090)	12537(Tax:10090)	Gene	Gene	pattern|appos|START_ENTITY pattern|nmod|END_ENTITY	Protein expression pattern of CDK11 -LRB- p58 -RRB- during testicular development in the mouse .
23703121	0	p58	92,95	CDK11	86,91	p58	CDK11	301323(Tax:10116)	252879(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11 -LRB- p58 -RRB- expression in PC12 cells through downregulating AKT pathway .
26470709	0	p58	23,26	CDK11	17,22	p58	CDK11	984	984	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Critical role of CDK11 -LRB- p58 -RRB- in human breast_cancer growth and angiogenesis .
20066559	0	p58	16,19	Cyclin_D3	0,9	p58	Cyclin D3	984	896	Gene	Gene	CDK11|appos|START_ENTITY involved|nsubj|CDK11 END_ENTITY|parataxis|involved	Cyclin_D3 / CDK11 -LRB- p58 -RRB- complex involved in Schwann cells proliferation repression caused by lipopolysaccharide .
25329545	0	p58	0,3	GCN2	45,49	p58	GCN2	984	440275	Gene	Gene	Inhibitor|nsubj|START_ENTITY Inhibitor|nmod|END_ENTITY	p58 -LRB- IPK -RRB- is an Inhibitor of the eIF2a Kinase GCN2 and its Localisation and Expression Underpin Protein Synthesis and ER Processing Capacity .
12082095	0	p58	15,18	cyclin_D3	66,75	p58	cyclin D3	984	896	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of p58 -LRB- PITSLRE -RRB- , a G2/M-specific protein kinase , with cyclin_D3 .
9677430	0	p59	15,18	CD2	69,72	p59	CD2	26003	914	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of p59 -LRB- fyn -RRB- with the T lymphocyte costimulatory receptor CD2 .
11093170	0	p59	20,23	fyn	24,27	p59	fyn	72572(Tax:10090)	14360(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A critical role for p59 -LRB- fyn -RRB- in CD2-based signal transduction .
9677430	0	p59	15,18	fyn	19,22	p59	fyn	26003	2534	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of p59 -LRB- fyn -RRB- with the T lymphocyte costimulatory receptor CD2 .
9460655	0	p59fyn	46,52	Prolactin	0,9	p59fyn	Prolactin	25150(Tax:10116)	24683(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells .
1338328	0	p59fyn	75,81	fyn	62,65	p59fyn	fyn	25150(Tax:10116)	25150(Tax:10116)	Gene	Gene	product|appos|START_ENTITY product|compound|END_ENTITY	Purification and characterization of a possible protooncogene fyn product , p59fyn , from a rat brain particulate fraction .
23109837	0	p60	74,77	Chromatin_Assembly_Factor-1	38,65	p60	Chromatin Assembly Factor-1	7984	8208	Gene	Gene	Evaluation|dep|START_ENTITY Evaluation|nmod|END_ENTITY	Tissue Microarray-Based Evaluation of Chromatin_Assembly_Factor-1 -LRB- CAF-1 -RRB- / p60 as Tumour Prognostic Marker .
8144934	0	p60	35,38	TNF	0,3	p60	TNF	8878	7124	Gene	Gene	receptor|amod|START_ENTITY internalization|nmod|receptor induces|dobj|internalization induces|nsubj|END_ENTITY	TNF induces internalization of the p60 receptor and shedding of the p80 receptor .
8805640	0	p60	86,89	TNF	57,60	p60	TNF	3437	7124	Gene	Gene	specific|nmod|START_ENTITY muteins|xcomp|specific muteins|nsubj|activation activation|nmod|B B|nmod|END_ENTITY	Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors .
9237663	0	p60	90,93	TNF	94,97	p60	TNF	8878	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine-331 in the p60 TNF receptor and inactivates the receptor-associated kinase .
9157979	0	p60	52,55	c-src	56,61	p60	c-src	8878	6714	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	Potent pseudosubstrate-based peptide inhibitors for p60 -LRB- c-src -RRB- protein tyrosine kinase .
11438547	0	p60	55,58	tumor_necrosis_factor	24,45	p60	tumor necrosis factor	109679(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Genetic deletion of the tumor_necrosis_factor receptor p60 or p80 abrogates ligand-mediated activation of nuclear factor-kappa B and of mitogen-activated protein kinases in macrophages .
7780141	0	p60	28,31	tumor_necrosis_factor	49,70	p60	tumor necrosis factor	7984	7124	Gene	Gene	forms|amod|START_ENTITY forms|nmod|receptors receptors|compound|END_ENTITY	Retinoids downregulate both p60 and p80 forms of tumor_necrosis_factor receptors in human histiocytic lymphoma U-937 cells .
8051124	0	p60	81,84	tumor_necrosis_factor	85,106	p60	tumor necrosis factor	8878	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor_necrosis_factor receptor .
16011831	0	p62	0,3	Akt	14,17	p62	Akt	23636	207	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|activity activity|compound|END_ENTITY	p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation .
26075355	0	p62	94,97	BiP	68,71	p62	BiP	8878	3309	Gene	Gene	targets|nmod|START_ENTITY targets|dobj|END_ENTITY	Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding .
7831152	0	p62	39,42	C-myc	33,38	p62	C-myc	23636	4609	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Mycosis fungoides : expression of C-myc p62 p53 , bcl-2 and PCNA proteins and absence of association with Epstein-Barr_virus .
8352531	0	p62	20,23	C-myc	14,19	p62	C-myc	23636	4609	Gene	Gene	oncoprotein|amod|START_ENTITY oncoprotein|amod|END_ENTITY	Expression of C-myc p62 oncoprotein in multiple_myeloma : an immunohistochemical study of 180 cases .
15286081	0	p62	15,18	Dok-6	0,5	Ret	Dok-6	19713(Tax:10090)	623279(Tax:10090)	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Dok-6 , a Novel p62 Dok family member , promotes Ret-mediated neurite outgrowth .
19398892	0	p62	21,24	NBR1	0,4	p62	NBR1	8878	4077	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets .
26012548	0	p62	54,57	Nrf2	22,26	p62	Nrf2	23636	4780	Gene	Gene	Activation|nmod|START_ENTITY Activation|compound|END_ENTITY	TLR Signaling Induces Nrf2 Pathway Activation through p62 - Triggered Keap1 Degradation .
25516445	0	p62	44,47	PGC1a	18,23	p62	PGC1a	23636	10891	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of PGC1a and accumulation of p62 in apocrine_carcinoma_of_the_breast .
11755531	0	p62	0,3	PKCzeta	33,40	p62	PKCzeta	23636	5590	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|inhibition inhibition|amod|complex complex|nmod|END_ENTITY	p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition .
11755531	0	p62	0,3	PKCzeta	81,88	p62	PKCzeta	23636	5590	Gene	Gene	forms|nsubj|START_ENTITY forms|dobj|inhibition inhibition|compound|END_ENTITY	p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition .
16011831	0	p62	0,3	PKCzeta	48,55	p62	PKCzeta	23636	5590	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	p62 modulates Akt activity via association with PKCzeta in neuronal survival and differentiation .
23794287	0	p62	41,44	Presenilin-1	0,12	p62	Presenilin-1	18226(Tax:10090)	19164(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation .
23759924	0	p62	77,80	Rac1	51,55	p62	Rac1	18412(Tax:10090)	19353(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway .
10585470	0	p62	20,23	SHP-1	0,5	p62	SHP-1	23636	5777	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	SHP-1 regulation of p62 -LRB- DOK -RRB- tyrosine phosphorylation in macrophages .
15493999	0	p62	83,86	SQSTM1	75,81	p62	SQSTM1	8878	8878	Gene	Gene	domain|appos|START_ENTITY domain|nmod|END_ENTITY	Structural and functional studies of mutations affecting the UBA domain of SQSTM1 -LRB- p62 -RRB- which cause Paget 's _ disease_of_bone .
12509240	0	p62	76,79	TFIIH	63,68	p62	TFIIH	36598(Tax:7227)	39202(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila_melanogaster : effects on the UV light sensitivity of a p62 mutant fly .
15533047	0	p62	27,30	TFIIH	82,87	p62	TFIIH	23636	2965	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Domain architecture of the p62 subunit from the human transcription/repair factor TFIIH deduced by limited proteolysis and mass spectrometry analysis .
15625236	0	p62	0,3	TFIIH	7,12	p62	TFIIH	23636	2966	Gene	Gene	START_ENTITY|appos|subunit subunit|compound|END_ENTITY	p62 , A TFIIH subunit , directly interacts with thyroid hormone receptor and enhances T3-mediated transcription .
24927592	0	p62	50,53	Twist1	79,85	p62	Twist1	18226(Tax:10090)	22160(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of cell proliferation and migration by p62 through stabilization of Twist1 .
1874294	0	p62	57,60	c-myc	61,66	p62	c-myc	23636	4609	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Use of the OM-11-906 monoclonal antibody for determining p62 c-myc expression by flow cytometry in relation to prognosis in colorectal_cancer .
2200214	0	p62	65,68	c-myc	69,74	p62	c-myc	23636	4609	Gene	Gene	oncogene|amod|START_ENTITY oncogene|amod|END_ENTITY	Comparison of deoxyribonucleic_acid ploidy and nuclear expressed p62 c-myc oncogene in the prognosis of colorectal_cancer .
25714028	0	p62	17,20	miR-372	0,7	p62	miR-372	8878	442917	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	miR-372 inhibits p62 in head_and_neck_squamous_cell_carcinoma in vitro and in vivo .
7531196	0	p62	129,132	nucleoporin_p54	92,107	p62	nucleoporin p54	117268(Tax:10116)	53372(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores : binding of nucleoporin_p54 to the rod domain of p62 .
24269898	0	p62	33,36	p38	0,3	p62	p38	8878	1432	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	p38 -LRB- MAPK -RRB- - regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling .
26029824	0	p62	131,134	p53	89,92	p62	p53	23636	7157	Gene	Gene	subunit|amod|START_ENTITY domains|nmod|subunit domains|nsubj|monitoring monitoring|nmod|interaction interaction|nmod|END_ENTITY	Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit .
7831152	0	p62	39,42	p53	43,46	p62	p53	23636	7157	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Mycosis fungoides : expression of C-myc p62 p53 , bcl-2 and PCNA proteins and absence of association with Epstein-Barr_virus .
23147249	0	p62	26,29	sequestosome_1	11,25	p62	sequestosome 1	8878	8878	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A role for sequestosome_1 / p62 in mitochondrial dynamics , import and genome integrity .
23564079	0	p62	60,63	sequestosome_1	45,59	p62	sequestosome 1	8878	8878	Gene	Gene	upregulation|dep|START_ENTITY upregulation|nmod|END_ENTITY	Bcl-2-dependent upregulation of autophagy by sequestosome_1 / p62 in vitro .
19124002	0	p63	31,34	AIRE	10,14	p63	AIRE	8626	326	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Wild-type AIRE cooperates with p63 in HLA class II expression of medullary thymic stromal cells .
19555433	0	p63	0,3	Alox12	35,41	p63	Alox12	8626	239	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	p63 directly induces expression of Alox12 , a regulator of epidermal barrier formation .
12788532	0	p63	41,44	CUSP	4,8	p63	CUSP	8626	8626	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	The CUSP DeltaNp63alpha isoform of human p63 is downregulated by solar-simulated ultraviolet radiation .
20559324	0	p63	17,20	Cables1	0,7	p63	Cables1	22061(Tax:10090)	63955(Tax:10090)	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress .
23703390	0	p63	31,34	Caspase-1	0,9	p63	Caspase-1	8626	834	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Caspase-1 is a novel target of p63 in tumor suppression .
17164413	0	p63	35,38	Dlx3	14,18	p63	Dlx3	8626	1747	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Homeobox gene Dlx3 is regulated by p63 during ectoderm development : relevance in the pathogenesis of ectodermal_dysplasias .
19282665	0	p63	59,62	Dlx3	20,24	p63	Dlx3	8626	1747	Gene	Gene	degradation|amod|START_ENTITY induces|dobj|degradation induces|nsubj|END_ENTITY	Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation .
18326838	0	p63	47,50	Dlx5	14,18	p63	Dlx5	8626	1749	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital_limb_defects .
23219093	0	p63	90,93	GJB6	0,4	p63	GJB6	8626	10804	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	GJB6 , of which mutations underlie Clouston_syndrome , is a potential direct target gene of p63 .
16446369	0	p63	25,28	GPX2	0,4	p63	GPX2	8626	2877	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	GPX2 , a direct target of p63 , inhibits oxidative stress-induced apoptosis in a p53-dependent manner .
18633439	0	p63	14,17	IKKalpha	0,8	p63	IKKalpha	8626	1147	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal_dysplasias .
26566817	0	p63	33,36	Interleukin_6	0,13	p63	Interleukin 6	8626	3569	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Interleukin_6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration .
24382117	3	p63	672,675	K5/14	677,682	p63	K5/14	8626	3852;3861	Gene	Gene	cells|nummod|START_ENTITY cells|amod|END_ENTITY	METHODS AND RESULTS : Using triple immunofluorescence labelling and quantitative RT-PCR for keratins , p63 , and smooth muscle actin , we demonstrated that syringomatous_tumour and LGAdSC contain p63 + / K5/14 + tumour cells , K10 + squamous cells , and K8/18 + glandular cells , with intermediary cells being found in both lineages .
11445003	0	p63	14,17	Mdm2	30,34	p63	Mdm2	8626	4193	Gene	Gene	Regulation|nmod|START_ENTITY function|nsubj|Regulation function|nmod|END_ENTITY	Regulation of p63 function by Mdm2 and MdmX .
19690760	0	p63	5,8	P53	0,3	p63	P53	8626	7157	Gene	Gene	assessment|amod|START_ENTITY END_ENTITY|appos|assessment	P53 , p63 and Ki-67 assessment in HPV-induced cervical neoplasia .
19458633	0	p63	75,78	Peroxisome_proliferator-activated_receptor-alpha	0,48	p63	Peroxisome proliferator-activated receptor-alpha	8626	5465	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor-alpha is a functional target of p63 in adult human keratinocytes .
24375645	0	p63	36,39	RBM24	20,25	p63	RBM24	8626	221662	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNA-binding protein RBM24 regulates p63 expression via mRNA stability .
12453409	0	p63	61,64	REDD1	0,5	p63	REDD1	22061(Tax:10090)	74747(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|appos|target	REDD1 , a developmentally regulated transcriptional target of p63 and p53 , links p63 to regulation of reactive oxygen species .
12453409	0	p63	80,83	REDD1	0,5	p63	REDD1	22061(Tax:10090)	74747(Tax:10090)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	REDD1 , a developmentally regulated transcriptional target of p63 and p53 , links p63 to regulation of reactive oxygen species .
20457941	0	p63	72,75	RNPC1	0,5	p63	RNPC1	8626	55544	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNPC1 , an RNA-binding protein and a target of the p53 family , regulates p63 expression through mRNA stability .
12374749	0	p63	67,70	SSRP1	0,5	p63	SSRP1	8626	6749	Gene	Gene	functions|nmod|START_ENTITY functions|nummod|END_ENTITY	SSRP1 functions as a co-activator of the transcriptional activator p63 .
21930775	0	p63	0,3	Satb1	14,19	p63	Satb1	22061(Tax:10090)	20230(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis .
18164684	0	p63	14,17	Scotin	0,6	p63	Scotin	8626	51246	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	Scotin : A new p63 target gene expressed during epidermal differentiation .
19194497	0	p63	11,14	ZEB1	0,4	p63	ZEB1	8626	6935	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia .
11546792	0	p63	14,17	epidermal_growth_factor_receptor	28,60	p63	epidermal growth factor receptor	8626	1956	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	p53 Homologue p63 represses epidermal_growth_factor_receptor expression .
12782800	0	p63	67,70	epidermal_growth_factor_receptor	14,46	p63	epidermal growth factor receptor	8626	1956	Gene	Gene	expression|amod|START_ENTITY decreases|dobj|expression decreases|nsubj|Inhibition Inhibition|nmod|signaling signaling|compound|END_ENTITY	Inhibition of epidermal_growth_factor_receptor signaling decreases p63 expression in head and neck squamous_carcinoma cells .
23207846	0	p63	34,37	epidermal_growth_factor_receptor	39,71	p63	epidermal growth factor receptor	8626	1956	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of p63 , epidermal_growth_factor_receptor -LRB- EGFR -RRB- and notch-1 in radicular_cysts , dentigerous_cysts_and_keratocystic_odontogenic_tumors .
23574722	0	p63	0,3	glutaminase_2	14,27	p63	glutaminase 2	8626	27165	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	p63 regulates glutaminase_2 expression .
24658133	0	p63	0,3	matrix_metallopeptidase_13	50,76	p63	matrix metallopeptidase 13	8626	4322	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	p63 transcriptionally regulates the expression of matrix_metallopeptidase_13 .
15367673	0	p63	14,17	p14ARF	46,52	p53	p14ARF	7157	1029	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Inhibition of p63 transcriptional activity by p14ARF : functional and physical link between human ARF_tumor suppressor and a member of the p53 family .
22468256	0	p63	19,22	p21	24,27	p63	p21	8626	644914	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
22468256	0	p63	19,22	p27	29,32	p63	p27	8626	3429	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
15965232	0	p63	15,18	p300	0,4	p63	p300	8626	2033	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	p300 regulates p63 transcriptional activity .
14562279	0	p63	12,15	p40	31,34	p63	p40	8626	8626	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of p63 and deltaNp63 -LRB- p40 -RRB- protein expression and gene amplification in esophageal carcinogenesis .
22056955	0	p63	28,31	p40	0,3	p63	p40	8626	8626	Gene	Gene	superior|nmod|START_ENTITY superior|nsubj|END_ENTITY	p40 -LRB- / \ Np63 -RRB- is superior to p63 for the diagnosis of pulmonary_squamous_cell_carcinoma .
10227293	0	p63	0,3	p53	9,12	p63	p53	22061(Tax:10090)	22060(Tax:10090)	Gene	Gene	homologue|nsubj|START_ENTITY homologue|compound|END_ENTITY	p63 is a p53 homologue required for limb and epidermal morphogenesis .
10452616	0	p63	19,22	p53	0,3	p63	p53	8626	7157	Gene	Gene	members|amod|START_ENTITY members|nummod|END_ENTITY	p53 Family members p63 and p73 are SAM domain-containing proteins .
11136565	0	p63	32,35	p53	18,21	p63	p53	8626	7157	Gene	Gene	homologue|dobj|START_ENTITY Expression|acl|homologue Expression|nmod|END_ENTITY	Expression of the p53 homologue p63 in early cervical neoplasia .
11181441	0	p63	23,26	p53	11,14	p63	p53	8626	7157	Gene	Gene	homolog|dobj|START_ENTITY END_ENTITY|acl|homolog	NBP is the p53 homolog p63 .
11238924	0	p63	60,63	p53	110,113	p63	p53	8626	7157	Gene	Gene	down-regulate|dobj|START_ENTITY down-regulate|nmod|interaction interaction|nmod|domain domain|compound|END_ENTITY	A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain .
11238924	0	p63	60,63	p53	42,45	p63	p53	8626	7157	Gene	Gene	down-regulate|dobj|START_ENTITY down-regulate|nsubj|subset subset|nmod|forms forms|nmod|END_ENTITY	A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain .
11474290	0	p63	0,3	p53	7,10	p63	p53	8626	7157	Gene	Gene	START_ENTITY|appos|homologue homologue|compound|END_ENTITY	p63 , a p53 homologue , is a selective nuclear marker of myoepithelial cells of the human breast .
11477076	0	p63	73,76	p53	126,129	p63	p53	8626	7157	Gene	Gene	domain|amod|START_ENTITY distinguish|dobj|domain distinguish|nmod|END_ENTITY	High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53 .
11522642	0	p63	0,3	p53	34,37	p63	p53	22061(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY associated|nsubjpass|expression associated|nmod|loss loss|compound|END_ENTITY	p63 expression is associated with p53 loss in oral-esophageal epithelia of p53-deficient mice .
11592094	0	p63	33,36	p53	18,21	p63	p53	8626	7157	Gene	Gene	homologues|dobj|START_ENTITY homologues|nsubj|Expression Expression|nmod|END_ENTITY	Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric_cancer .
11893750	0	p63	67,70	p53	46,49	p63	p53	8626	7157	Gene	Gene	activities|amod|START_ENTITY inhibits|dobj|activities inhibits|nsubj|interaction interaction|nmod|mutants mutants|compound|END_ENTITY	Physical interaction with human tumor-derived p53 mutants inhibits p63 activities .
11957139	0	p63	51,54	p53	27,30	p63	p53	8626	7157	Gene	Gene	members|amod|START_ENTITY members|nummod|END_ENTITY	Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis .
12027449	0	p63	20,23	p53	0,3	p63	p53	22061(Tax:10090)	22060(Tax:10090)	Gene	Gene	p51|appos|START_ENTITY p51|nummod|END_ENTITY	p53 gene family p51 -LRB- p63 -RRB- - encoded , secondary transactivator p51B -LRB- TAp63alpha -RRB- occurs without forming an immunoprecipitable complex with MDM2 , but responds to genotoxic stress by accumulation .
15308639	0	p63	95,98	p53	82,85	p63	p53	8626	7157	Gene	Gene	homologs|amod|START_ENTITY homologs|compound|END_ENTITY	CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73 .
15608418	0	p63	5,8	p53	0,3	p63	p53	8626	7157	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|appos|expression	p53 , p63 and p73 expression in squamous_cell_carcinomas of the head and neck and their response to cisplatin exposure .
15837625	0	p63	40,43	p53	109,112	p63	p53	22061(Tax:10090)	22060(Tax:10090)	Gene	Gene	mutant|nmod|START_ENTITY predisposition|nmod|mutant predisposition|dep|evidence evidence|nmod|functions functions|nmod|family family|compound|END_ENTITY	Tumor predisposition in mice mutant for p63 and p73 : evidence for broader_tumor suppressor functions for the p53 family .
15846087	0	p63	56,59	p53	29,32	p63	p53	8626	7157	Gene	Gene	suppressor|nmod|START_ENTITY suppressor|dobj|functions functions|compound|END_ENTITY	The tumor suppressor protein p53 functions similarly to p63 and p73 in activating transcription in vitro .
16831876	0	p63	90,93	p53	135,138	p63	p53	8626	7157	Gene	Gene	enzyme|nmod|START_ENTITY Glyoxalase_II|appos|enzyme factor|nsubj|Glyoxalase_II factor|nmod|family family|compound|END_ENTITY	Glyoxalase_II , a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73 , is a pro-survival factor of the p53 family .
16870177	0	p63	53,56	p53	108,111	p63	p53	8626	7157	Gene	Gene	sequence|nmod|START_ENTITY Derivation|nmod|sequence reveals|nsubj|Derivation reveals|dobj|requirements requirements|acl:relcl|distinct distinct|nmod|END_ENTITY	Derivation of the consensus DNA-binding sequence for p63 reveals unique requirements that are distinct from p53 .
16959223	0	p63	0,3	p53	28,31	p63	p53	8626	7157	Gene	Gene	START_ENTITY|appos|members members|nmod|family family|compound|END_ENTITY	p63 and p73 , members of the p53 gene family , transactivate PKCdelta .
17401431	0	p63	22,25	p53	53,56	p63	p53	8626	7157	Gene	Gene	interactions|nmod|START_ENTITY involved|nsubj|interactions involved|nmod|gain gain|compound|END_ENTITY	Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function ?
18026135	0	p63	25,28	p53	71,74	p63	p53	8626	7157	Gene	Gene	presence|amod|START_ENTITY presence|nmod|carcinogenesis carcinogenesis|amod|complex complex|nmod|sequence sequence|nummod|END_ENTITY	p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis .
18626511	0	p63	24,27	p53	58,61	p63	p53	8626	7157	Gene	Gene	mutants|amod|START_ENTITY mutants|nmod|transactivation transactivation|nmod|END_ENTITY	Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes .
18626511	0	p63	69,72	p53	58,61	p63	p53	8626	7157	Gene	Gene	responsive|amod|START_ENTITY genes|amod|responsive and/or|dobj|genes and/or|nsubj|effects effects|nmod|mutants mutants|nmod|transactivation transactivation|nmod|END_ENTITY	Differential effects of p63 mutants on transactivation of p53 and/or p63 responsive genes .
19458240	0	p63	0,3	p53	16,19	p63	p53	8626	7157	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	p63 antagonizes p53 to promote the survival of embryonic neural precursor cells .
20140014	0	p63	67,70	p53	54,57	p63	p53	8626	7157	Gene	Gene	homologs|dobj|START_ENTITY homologs|nsubj|basis basis|nmod|proteins proteins|acl|interacting interacting|nmod|END_ENTITY	Molecular basis of S100 proteins interacting with the p53 homologs p63 and p73 .
20484388	0	p63	0,3	p53	30,33	p63	p53	8626	7157	Gene	Gene	START_ENTITY|appos|ancestors ancestors|nmod|END_ENTITY	p63 and p73 , the ancestors of p53 .
20485546	0	p63	27,30	p53	22,25	p63	p53	22061(Tax:10090)	22060(Tax:10090)	Gene	Gene	suppressors|nummod|START_ENTITY suppressors|nummod|END_ENTITY	The tumor suppressors p53 , p63 , and p73 are regulators of microRNA processing complex .
20818419	0	p63	64,67	p53	45,48	p63	p53	8626	7157	Gene	Gene	members|amod|START_ENTITY members|compound|END_ENTITY	PRIMA-1 -LRB- MET -RRB- / APR-246 targets mutant forms of p53 family members p63 and p73 .
20972454	0	p63	20,23	p53	7,10	p63	p53	8626	7157	Gene	Gene	control|amod|START_ENTITY subverts|dobj|control subverts|nsubj|END_ENTITY	Mutant p53 subverts p63 control over KLF4 expression in keratinocytes .
21114965	0	p63	45,48	p53	26,29	p63	p53	22061(Tax:10090)	22060(Tax:10090)	Gene	Gene	members|dobj|START_ENTITY members|nsubj|expression expression|nmod|END_ENTITY	Dynamic expression of the p53 family members p63 and p73 in the mouse and human telencephalon during development and in adulthood .
21760596	0	p63	0,3	p53	76,79	p63	p53	8626	7157	Gene	Gene	suppressor|nsubj|START_ENTITY suppressor|acl|interacting interacting|nmod|END_ENTITY	p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53 .
22203497	0	p63	16,19	p53	7,10	p63	p53	8626	7157	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome .
22361592	0	p63	90,93	p53	17,20	p63	p53	8626	7157	Gene	Gene	overlapping|nmod|START_ENTITY overlapping|nsubj|mutants mutants|compound|END_ENTITY	Gain-of-function p53 mutants have widespread genomic locations partially overlapping with p63 .
22468256	0	p63	19,22	p53	14,17	p63	p53	8626	7157	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of p53 , p63 , p21 , p27 , ki-67 in paranasal_sinus_squamous_cell_carcinoma and inverted_papilloma .
22549865	0	p63	18,21	p53	36,39	p63	p53	8626	7157	Gene	Gene	faces|nmod|START_ENTITY -LSB-|dobj|faces -RSB-|advcl|-LSB- -RSB-|nsubj|Janus Janus|nmod|family family|compound|END_ENTITY	-LSB- The two faces of p63 , Janus of the p53 gene family -RSB- .
22641291	0	p63	53,56	p53	157,160	p63	p53	8626	7157	Gene	Gene	p53|nummod|START_ENTITY accumulations|nmod|p53 induces|dobj|accumulations induces|nmod|increases increases|nmod|END_ENTITY	Fludarabine_nucleoside induces accumulations of p53 , p63 and p73 in the nuclei of human B-lymphoid cell lines , with cytosolic and mitochondrial increases in p53 .
23420876	0	p63	0,3	p53	22,25	p63	p53	8626	7157	Gene	Gene	repressor|nsubj|START_ENTITY repressor|compound|END_ENTITY	p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis .
23924551	0	p63	34,37	p53	39,42	p63	p53	8626	7157	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of p63 , p53 in urinary_bladder_carcinoma .
25536625	0	p63	39,42	p53	34,37	p63	p53	8626	7157	Gene	Gene	c-myc|amod|START_ENTITY expression|amod|c-myc expression|nmod|END_ENTITY	Immunohistochemical expression of p53 , p63 , c-myc , p21 -LRB- WAF1/cip1 -RRB- and p27 -LRB- kip1 -RRB- proteins in urothelial_bladder_carcinoma : correlation with clinicopathological parameters .
27019188	0	p63	76,79	p53	92,95	p63	p53	8626	7157	Gene	Gene	targeting|dobj|START_ENTITY targeting|advcl|regulate regulate|dobj|expression expression|compound|END_ENTITY	MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression .
25777256	0	p63	0,3	p63	112,115	p63	p63	8626	8626	Gene	Gene	Expression|compound|START_ENTITY Expression|nmod|Expression Expression|amod|END_ENTITY	p63 Expression in the Gerbil Hippocampus Following Transient Ischemia and Effect of Ischemic Preconditioning on p63 Expression in the Ischemic Hippocampus .
25777256	0	p63	112,115	p63	0,3	p63	p63	8626	8626	Gene	Gene	Expression|amod|START_ENTITY Expression|nmod|Expression Expression|compound|END_ENTITY	p63 Expression in the Gerbil Hippocampus Following Transient Ischemia and Effect of Ischemic Preconditioning on p63 Expression in the Ischemic Hippocampus .
17606614	0	p63RhoGEF	27,36	Galphaq	0,7	p63RhoGEF	Galphaq	115557;9181	2776	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl_homology-associated pleckstrin homology domain .
10657951	0	p63alpha	32,40	p53	18,21	p63alpha	p53	8626	7157	Gene	Gene	homologue|dobj|START_ENTITY Expression|acl|homologue Expression|nmod|END_ENTITY	Expression of the p53 homologue p63alpha and deltaNp63alpha in normal and neoplastic cells .
11600462	0	p63alpha	32,40	p53	18,21	p63alpha	p53	8626	7157	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Expression of the p53 homologue p63alpha and DeltaNp63alpha in the neoplastic sequence of Barrett 's _ oesophagus : correlation with morphology and p53 protein .
1500859	0	p64	142,145	IL-2R	146,151	p64	IL-2R	3561	3559	Gene	Gene	chain|amod|START_ENTITY chain|compound|END_ENTITY	Characterization of the interleukin_2_receptors -LRB- IL-2R -RRB- expressed on human natural killer cells activated in vivo by IL-2 : association of the p64 IL-2R gamma chain with the IL-2R_beta chain in functional intermediate-affinity IL-2R .
10498867	0	p65	18,21	53BP2	31,36	p65	53BP2	5970	7159	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2 .
24984534	0	p65	47,50	BRMS1	0,5	p65	BRMS1	5970	25855	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	BRMS1 inhibits expression of NF-kappaB subunit p65 , uPA and OPN in ovarian_cancer cells .
20628365	0	p65	27,30	Dishevelled	0,11	p65	Dishevelled	5970	8215	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dishevelled interacts with p65 and acts as a repressor of NF-kB-mediated transcription .
23803172	0	p65	53,56	HMGB1	31,36	p65	HMGB1	5970	3146	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression and significance of HMGB1 , TLR4 and NF-kB p65 in human epidermal_tumors .
20823682	0	p65	148,151	ICAM-1	167,173	p65	ICAM-1	19697(Tax:10090)	15894(Tax:10090)	Gene	Gene	recruitment|amod|START_ENTITY reducing|dobj|recruitment reducing|nmod|promoters promoters|compound|END_ENTITY	Amelioration of dextran sulfate_sodium-induced chronic_colitis by sulfasalazine_salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters .
26102347	0	p65	27,30	IKKb	8,12	p65	IKKb	19697(Tax:10090)	16150(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Loss Loss|nmod|END_ENTITY	Loss of IKKb but Not NF-kB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells .
26718331	0	p65	27,30	IKKb	39,43	p65	IKKb	5970	3551	Gene	Gene	START_ENTITY|nmod|promoter promoter|compound|END_ENTITY	Survivin activates NF - kB p65 via the IKKb promoter in esophageal_squamous_cell_carcinoma .
16046471	0	p65	23,26	IKKbeta	0,7	p65	IKKbeta	19697(Tax:10090)	16150(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	IKKbeta phosphorylates p65 at S468 in transactivaton domain 2 .
22708120	0	p65	54,57	IL-33	8,13	p65	IL-33	5970	90865	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Nuclear IL-33 is a transcriptional regulator of NF-kB p65 and induces endothelial cell activation .
21262351	0	p65	15,18	Keap1	34,39	p65	Keap1	5970	9817	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway .
24936866	0	p65	14,17	MCP-1	80,85	p65	MCP-1	5970	6347	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Nuclear NF-kB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1 , RANTES and the severity of type 2 diabetic_nephropathy .
24063540	0	p65	105,108	MMP1	145,149	p65	MMP1	5970	4312	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Astrocyte_elevated_gene-1 is associated with metastasis in head_and_neck_squamous_cell_carcinoma through p65 phosphorylation and upregulation of MMP1 .
26877865	0	p65	128,131	MiR-690	0,7	p65	MiR-690	19697(Tax:10090)	751543(Tax:10090)	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MiR-690 , a Runx2-targeted miRNA , regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65 .
10521409	0	p65	40,43	NF-kappaB	30,39	p65	NF-kappaB	5970	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain .
10773449	0	p65	4,7	NF-kappaB	20,29	p65	NF-kappaB	5970	4790	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The p65 domain from NF-kappaB is an efficient human activator in the tetracycline-regulatable gene expression system .
11564889	0	p65	4,7	NF-kappaB	26,35	p65	NF-kappaB	5970	4790	Gene	Gene	subunit|compound|START_ENTITY subunit|nmod|interacts interacts|amod|END_ENTITY	The p65 -LRB- RelA -RRB- subunit of NF-kappaB interacts with the histone_deacetylase -LRB- HDAC -RRB- corepressors HDAC1 and HDAC2 to negatively regulate gene expression .
14600157	0	p65	131,134	NF-kappaB	147,156	p65	NF-kappaB	5970	4790	Gene	Gene	subunit|appos|START_ENTITY subunit|nmod|END_ENTITY	Fas-associated_factor-1 inhibits nuclear factor-kappaB -LRB- NF-kappaB -RRB- activity by interfering with nuclear translocation of the RelA -LRB- p65 -RRB- subunit of NF-kappaB .
14600157	0	p65	131,134	NF-kappaB	56,65	p65	NF-kappaB	5970	4790	Gene	Gene	subunit|appos|START_ENTITY translocation|nmod|subunit interfering|nmod|translocation inhibits|advcl|interfering inhibits|dobj|activity activity|dep|END_ENTITY	Fas-associated_factor-1 inhibits nuclear factor-kappaB -LRB- NF-kappaB -RRB- activity by interfering with nuclear translocation of the RelA -LRB- p65 -RRB- subunit of NF-kappaB .
15073170	0	p65	105,108	NF-kappaB	12,21	p65	NF-kappaB	5970	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY involving|dobj|phosphorylation mechanism|acl|involving induces|nmod|mechanism induces|dobj|activation activation|amod|END_ENTITY	p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal_S6_kinase_1 .
15506973	0	p65	40,43	NF-kappaB	45,54	p65	NF-kappaB	5970	4790	Gene	Gene	modification|appos|START_ENTITY END_ENTITY|nsubj|modification	Post-translational modification of RelA -LRB- p65 -RRB- NF-kappaB .
15802625	0	p65	135,138	NF-kappaB	68,77	p65	NF-kappaB	5970	4790	Gene	Gene	phosphorylation|nmod|START_ENTITY mechanism|dep|phosphorylation mechanism|nmod|activation activation|nmod|END_ENTITY	A new cellular signaling mechanism for angiotensin_II activation of NF-kappaB : An IkappaB-independent , RSK-mediated phosphorylation of p65 .
15980040	0	p65	124,127	NF-kappaB	114,123	p65	NF-kappaB	5970	4790	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|amod|END_ENTITY	Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation .
16624823	0	p65	142,145	NF-kappaB	61,70	p65	NF-kappaB	5970	4790	Gene	Gene	activation|compound|START_ENTITY modulation|nmod|activation suppresses|nmod|modulation suppresses|dobj|activation activation|amod|END_ENTITY	Plumbagin -LRB- 5-hydroxy-2-methyl-1 ,4 - naphthoquinone -RRB- suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation , leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents .
16636680	0	p65	125,128	NF-kappaB	129,138	p65	NF-kappaB	5970	4790	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Nuclear BCL-10 expression is common in lymphoplasmacytic_lymphoma / Waldenstr m macroglobulinemia and does not correlate with p65 NF-kappaB activation .
17530443	0	p65	18,21	NF-kappaB	42,51	p65	NF-kappaB	5970	4790	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	Dual knockdown of p65 and p50 subunits of NF-kappaB by siRNA inhibits the induction of inflammatory cytokines and significantly enhance apoptosis in human primary synoviocytes treated with tumor_necrosis_factor-alpha .
17982104	0	p65	155,158	NF-kappaB	118,127	p65	NF-kappaB	5970	4790	Gene	Gene	phosphorylation|amod|START_ENTITY suppression|nmod|phosphorylation inactivating|nmod|suppression inactivating|dobj|END_ENTITY	Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation .
19789307	0	p65	18,21	NF-kappaB	8,17	p65	NF-kappaB	5970	4790	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Nuclear NF-kappaB p65 phosphorylation at serine 276 by protein kinase A contributes to the malignant phenotype of head_and_neck_cancer .
19864627	0	p65	67,70	NF-kappaB	14,23	p65	NF-kappaB	5970	4790	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|amod|END_ENTITY	Regulation of NF-kappaB activity through lysine monomethylation of p65 .
20001970	0	p65	39,42	NF-kappaB	44,53	p65	NF-kappaB	19697(Tax:10090)	18033(Tax:10090)	Gene	Gene	RelA|appos|START_ENTITY END_ENTITY|nsubj|RelA	Thr435 phosphorylation regulates RelA -LRB- p65 -RRB- NF-kappaB subunit transactivation .
20080798	0	p65	82,85	NF-kappaB	14,23	p65	NF-kappaB	5970	4790	Gene	Gene	methylation|nmod|START_ENTITY Regulation|nmod|methylation Regulation|nmod|END_ENTITY	Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65 .
20823682	0	p65	148,151	NF-kappaB	117,126	p65	NF-kappaB	19697(Tax:10090)	18033(Tax:10090)	Gene	Gene	recruitment|amod|START_ENTITY recruitment|amod|END_ENTITY	Amelioration of dextran sulfate_sodium-induced chronic_colitis by sulfasalazine_salicylazosulfapyridine via reducing NF-kappaB transcription factor p65 recruitment to ICAM-1 gene promoters .
23489828	0	p65	25,28	NF-kappaB	15,24	p65	NF-kappaB	19697(Tax:10090)	18033(Tax:10090)	Gene	Gene	attenuates|amod|START_ENTITY attenuates|amod|END_ENTITY	Suppression of NF-kappaB p65 expression attenuates delayed xenograft rejection .
8995303	0	p65	51,54	NF-kappaB	41,50	p65	NF-kappaB	5970	4790	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells .
9315679	0	p65	78,81	NF-kappaB	92,101	p65	NF-kappaB	5970	4790	Gene	Gene	RelA|appos|START_ENTITY epsilon|appos|RelA member|nmod|epsilon mediated|nsubj|member mediated|dobj|transcription transcription|amod|END_ENTITY	A new member of the I kappaB protein family , I kappaB epsilon , inhibits RelA -LRB- p65 -RRB- - mediated NF-kappaB transcription .
9405476	0	p65	137,140	NF-kappaB	43,52	p65	NF-kappaB	5970	4790	Gene	Gene	subunit|amod|START_ENTITY phosphorylation|nmod|subunit accompanied|nmod|phosphorylation accompanied|nsubjpass|Activation Activation|nmod|factor factor|acl|END_ENTITY	Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein_kinase_II-mediated phosphorylation of the p65 subunit .
9412459	0	p65	125,128	NF-kappaB	49,58	p65	NF-kappaB	5970	4790	Gene	Gene	targeting|dobj|START_ENTITY activates|advcl|targeting activates|dobj|END_ENTITY	Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65 .
9837931	0	p65	120,123	NF-kappaB	88,97	p65	NF-kappaB	5970	4790	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|dobj|END_ENTITY	The anti-inflammatory sesquiterpene_lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65 .
11733537	0	p65	153,156	NF-kappa_B	168,178	p65	NF-kappa B	19697(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Distinct roles of the Ikappa_B_kinase_alpha and beta subunits in liberating nuclear_factor_kappa_B -LRB- NF-kappa_B -RRB- from Ikappa B and in phosphorylating the p65 subunit of NF-kappa_B .
8114725	0	p65	101,104	NF-kappa_B	116,126	p65	NF-kappa B	5970	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The bZIP transactivator of Epstein-Barr_virus , BZLF1 , functionally and physically interacts with the p65 subunit of NF-kappa_B .
8188306	0	p65	34,37	NF-kappa_B	70,80	p65	NF-kappa B	5970	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa_B is located on chromosome 11q12 .
8199054	0	p65	55,58	NF-kappa_B	70,80	p65	NF-kappa B	5970	447632(Tax:8355)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	XrelA , a Xenopus maternal and zygotic homologue of the p65 subunit of NF-kappa_B .
8234333	0	p65	28,31	NF-kappa_B	43,53	p65	NF-kappa B	19697(Tax:10090)	18033(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Antisense inhibition of the p65 subunit of NF-kappa_B blocks tumorigenicity and causes tumor regression .
17720813	0	p65	51,54	NOS2	0,4	p65	NOS2	5970	4843	Gene	Gene	regulation|nmod|START_ENTITY regulation|nummod|END_ENTITY	NOS2 regulation of NF-kappaB by S-nitrosylation of p65 .
14587029	0	p65	86,89	PPARgamma	19,28	p65	PPARgamma	5970	5468	Gene	Gene	leads|nmod|START_ENTITY leads|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta .
17451432	0	p65	33,36	RARalpha	66,74	p65	RARalpha	5970	5914	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Involvement of NF-kappaB subunit p65 and retinoic_acid receptors , RARalpha and RXRalpha , in transcriptional regulation of the human GnRH_II gene .
15355351	0	p65	52,55	RNA_helicase_A	0,14	p65	RNA helicase A	5970	1660	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	RNA_helicase_A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator .
10894954	0	p65	60,63	RelA	55,59	p65	RelA	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Genomic structure and chromosome location of the mouse RelA p65 gene -LRB- Rela -RRB- .
12509469	0	p65	20,23	RelA	14,18	p65	RelA	5970	5970	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of RelA -LRB- p65 -RRB- function by the large subunit of replication factor C .
18631125	0	p65	24,27	RelA	18,22	p65	RelA	5970	5970	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the RelA -LRB- p65 -RRB- transactivation domain .
21737676	0	p65	18,21	RelA	12,16	p65	RelA	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of RelA -LRB- p65 -RRB- threonine 505 phosphorylation in the regulation of cell growth , survival , and migration .
25777430	0	p65	22,25	RelA	27,31	p65	RelA	5970	5970	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Nuclear expression of p65 -LRB- RelA -RRB- in patients receiving post-operative radiotherapy for locally advanced squamous_cell_carcinoma_of_the_head_and_neck .
25868613	0	p65	22,25	RelA	27,31	p65	RelA	5970	5970	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Nuclear expression of p65 -LRB- RelA -RRB- in patients receiving post-operative radiotherapy for locally advanced squamous_cell_carcinoma_of_the_head_and_neck .
22592403	0	p65	6,9	Rel_A	0,5	p65	Rel A	5970	5970	Gene	Gene	required|nsubjpass|START_ENTITY END_ENTITY|parataxis|required	Rel_A / p65 is required for cytokine-induced myotube_atrophy .
10894954	0	p65	60,63	Rela	70,74	p65	Rela	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosome location of the mouse RelA p65 gene -LRB- Rela -RRB- .
25957047	0	p65	33,36	Reptin	0,6	p65	Reptin	5970	10856	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Reptin physically interacts with p65 and represses NF-kB activation .
26187476	0	p65	138,141	TLR-4	127,132	p65	TLR-4	5970	7099	Gene	Gene	signal|amod|START_ENTITY signal|compound|END_ENTITY	Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4 / NFkB p65 signal pathway .
15980040	0	p65	124,127	TNF-alpha	51,60	p65	TNF-alpha	5970	7124	Gene	Gene	phosphorylation|amod|START_ENTITY modulation|nmod|phosphorylation regulates|nmod|modulation regulates|dobj|production production|amod|END_ENTITY	Inhibitor-kappaB kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappaB p65 subunit phosphorylation .
25088585	0	p65	47,50	TRIM13	31,37	p65	TRIM13	5970	10206	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Participation of the E3-ligase TRIM13 in NF-kB p65 activation and NFAT-dependent activation of c-Rel upon T-cell receptor engagement .
8995303	0	p65	51,54	cyclooxygenase-2	16,32	p65	cyclooxygenase-2	5970	5743	Gene	Gene	factor|amod|START_ENTITY END_ENTITY|nmod|factor	Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells .
26498481	0	p65	49,52	cyclooxygenase-2_and_nuclear_factor-kB	10,48	p65	cyclooxygenase-2 and nuclear factor-kB	19697(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Increased cyclooxygenase-2_and_nuclear_factor-kB / p65 expression in mouse hippocampi after systemic administration of tetanus toxin .
10870681	0	p65	74,77	epidermal_growth_factor_receptor	80,112	p65	epidermal growth factor receptor	5970	1956	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
18922796	0	p65	121,124	insulin-like_growth_factor-I	23,51	p65	insulin-like growth factor-I	25716(Tax:10116)	24482(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|nmod|END_ENTITY	Stimulatory effects of insulin-like_growth_factor-I on growth plate chondrogenesis are mediated by nuclear factor-kappaB p65 .
17320050	0	p65	80,83	interleukin-1beta	13,30	p65	interleukin-1beta	25716(Tax:10116)	24494(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	NMDA-induced interleukin-1beta expression is mediated by nuclear factor-kappa B p65 in the retina .
11532196	0	p65	36,39	nuclear_factor-kappaB	83,104	p65	nuclear factor-kappaB	5970	4790	Gene	Gene	p50|amod|START_ENTITY effects|nmod|p50 oligonucleotides|nsubj|effects oligonucleotides|nmod|expression expression|amod|END_ENTITY	Different effects of antisense RelA p65 and NF-kappaB1 p50 oligonucleotides on the nuclear_factor-kappaB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells .
12213593	0	p65	72,75	nuclear_factor-kappaB	50,71	p65	nuclear factor-kappaB	5970	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Regulation of the transcriptional activity of the nuclear_factor-kappaB p65 subunit .
15210855	0	p65	4,7	nuclear_factor-kappaB	19,40	p65	nuclear factor-kappaB	5970	4790	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p65 subunit of nuclear_factor-kappaB is a molecular target for radiation sensitization of human squamous_carcinoma cells .
17638900	0	p65	109,112	nuclear_factor-kappaB	14,35	p65	nuclear factor-kappaB	5970	4790	Gene	Gene	DNA|amod|START_ENTITY inhibition|nmod|DNA induced|dobj|inhibition O6-methylguanine|acl|induced involves|dobj|O6-methylguanine involves|nsubj|Inhibition Inhibition|nmod|activity activity|amod|END_ENTITY	Inhibition of nuclear_factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding .
19706766	0	p65	80,83	nuclear_factor-kappaB	58,79	p65	nuclear factor-kappaB	5970	4790	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	MUC1-C oncoprotein functions as a direct activator of the nuclear_factor-kappaB p65 transcription factor .
12856595	0	p65	39,42	nuclear_factor-kappa_B	16,38	p65	nuclear factor-kappa B	5970	4790	Gene	Gene	antisense|amod|START_ENTITY antisense|amod|END_ENTITY	-LSB- The effects of nuclear_factor-kappa_B p65 antisense oligonucleotides on expression of proinflammatory cytokines in lamina propria mononuclear cells from patients with ulcerative_colitis -RSB- .
24146067	0	p65	64,67	nuclear_factor_kappa_B	23,45	p65	nuclear factor kappa B	25716(Tax:10116)	309165(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Biphasic activation of nuclear_factor_kappa_B and expression of p65 and c-Rel after traumatic_brain_injury in rats .
22305266	0	p65	27,30	p21	12,15	p65	p21	5970	644914	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Cytoplasmic p21 induced by p65 prevents doxorubicin-induced cell death in pancreatic_carcinoma cell line .
2504884	0	p65	63,66	p38	87,90	p65	p38	64689	1432	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Subcellular distribution of 65,000 calmodulin-binding_protein -LRB- p65 -RRB- and synaptophysin -LRB- p38 -RRB- in adrenal medulla .
10870681	0	p65	74,77	p53	165,168	p65	p53	5970	7157	Gene	Gene	expression|appos|START_ENTITY analysis|nmod|expression oncogene|nsubj|analysis oncogene|iobj|END_ENTITY	Immunohistochemical analysis of expression of a 65 kDa oncofetal protein -LRB- p65 -RRB- , epidermal_growth_factor_receptor -LRB- EGFR -RRB- , oncogene c-erb_B2 and tumor suppressor gene p53 protein products in breast_cancer patients .
15073170	0	p65	105,108	p53	0,3	p65	p53	5970	7157	Gene	Gene	phosphorylation|nmod|START_ENTITY involving|dobj|phosphorylation mechanism|acl|involving induces|nmod|mechanism induces|nsubj|END_ENTITY	p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal_S6_kinase_1 .
18269916	0	p65	20,23	p53	27,30	p65	p53	5970	7157	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|END_ENTITY	Induction of p21 by p65 in p53 null cells treated with Doxorubicin .
8833654	0	p65	98,101	rel_A	69,74	p65	rel A	25716(Tax:10116)	309165(Tax:10116)	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
8670842	0	p65/NF-kappaB	43,56	serum_response_factor	18,39	p65/NF-kappaB	serum response factor	5970;4790	6722	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the serum_response_factor by p65/NF-kappaB .
16769540	0	p65_NF-kappaB	12,25	RelA	26,30	p65 NF-kappaB	RelA	19697(Tax:10090)	19697(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of p65_NF-kappaB / RelA in pancreatitis-induced Kupffer cell apoptosis .
8101106	0	p65_subunit_of_NF-kappa_B	34,59	CD11b	66,71	p65 subunit of NF-kappa B	CD11b	5970	3684	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Antisense oligonucleotides to the p65_subunit_of_NF-kappa_B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes .
16934752	0	p66	4,7	DNA_polymerase_delta	28,48	p66	DNA polymerase delta	10714	5424	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	The p66 and p12 subunits of DNA_polymerase_delta are modified by ubiquitin and ubiquitin-like proteins .
18157942	0	p66	34,37	DNA_polymerase_delta	48,68	p66	DNA polymerase delta	10714	5424	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of the C subunit -LRB- p66 -RRB- of human DNA_polymerase_delta .
15695365	0	p66	56,59	Mi-2	27,31	p66	Mi-2	39212(Tax:7227)	40170(Tax:7227)	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Developmental roles of the Mi-2 / NURD-associated protein p66 in Drosophila .
9192859	0	p66	30,33	SHC	26,29	p66	SHC	10714	6464	Gene	Gene	cDNA|amod|START_ENTITY END_ENTITY|dobj|cDNA	Characterization of human SHC p66 cDNA and its processed pseudogene mapping to Xq12-q13 .1 .
16170380	0	p66	14,17	Shc	18,21	p66	Shc	10714	6464	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Expression of p66 -LRB- Shc -RRB- protein correlates with proliferation of human prostate_cancer cells .
16487929	0	p66	0,3	Shc	4,7	p66	Shc	10714	6464	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p66 -LRB- Shc -RRB- gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway .
25202246	0	p66	118,121	Shc	122,125	p66	Shc	20416(Tax:10090)	20416(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66 -LRB- Shc - / - -RRB- mouse .
9696394	0	p66	98,101	Shc	102,105	p66	Shc	10714	6464	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Constitutively tyrosine phosphorylated p52 Shc in breast_cancer cells : correlation with ErbB2 and p66 Shc expression .
24349153	0	p66	17,20	TNFa	0,4	p66	TNFa	10714	7124	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	TNFa signals via p66 -LRB- Shc -RRB- to induce E-Selectin , promote leukocyte transmigration and enhance permeability in human endothelial cells .
18191273	6	p66	854,857	shc	858,861	p66	shc	20416(Tax:10090)	20416(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	These data suggest that prevention of apoptosis conferred by ablation of p66 -LRB- shc -RRB- results from changed ROS-scavenging , but not inhibition of ROS generation .
21439852	0	p66	21,24	shc	25,28	p66	shc	10714	6464	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hemodialysis induces p66 -LRB- shc -RRB- gene expression in nondiabetic humans : correlations with oxidative stress and systemic inflammation .
25403183	0	p66b	31,35	Sufu	14,18	p66b	Sufu	57459	51684	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Regulation of Sufu activity by p66b and Mycbp provides new insight into vertebrate Hedgehog signaling .
22802702	0	p66shc	13,19	Endothelial_Nitric_Oxide_Synthase	62,95	p66shc	Endothelial Nitric Oxide Synthase	20416(Tax:10090)	4846	Gene	Gene	START_ENTITY|dep|Phosphorylation Phosphorylation|nmod|END_ENTITY	Tat-Mediated p66shc Transduction Decreased Phosphorylation of Endothelial_Nitric_Oxide_Synthase in Endothelial Cells .
15869823	0	p67	34,37	Munc18-1	24,32	p67	Munc18-1	25558(Tax:10116)	25558(Tax:10116)	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Nuclear localization of Munc18-1 -LRB- p67 -RRB- in the adult rat brain and PC12 cells .
11123929	0	p67	90,93	PKR	57,60	p67	PKR	945	5610	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	In vivo regulation of the dsRNA-dependent protein kinase PKR by the cellular glycoprotein p67 .
12706348	0	p67	113,116	eIF2alpha	78,87	p67	eIF2alpha	64370(Tax:10116)	502531(Tax:10116)	Gene	Gene	associated|dobj|START_ENTITY END_ENTITY|acl|associated	Mutation at the acidic residue-rich domain of eukaryotic initiation factor 2 -LRB- eIF2alpha -RRB- - associated glycoprotein p67 increases the protection of eIF2alpha phosphorylation during heat_shock .
15260500	0	p67phox	83,90	gp91phox	41,49	p67phox	gp91phox	4688	1536	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the flavoprotein domain of gp91phox upon interaction with N-terminal p67phox -LRB- 1-210 -RRB- and the Rac complex .
20225156	0	p68	29,32	Ddx5	34,38	p68	Ddx5	1655	1655	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of the RNA helicase p68 -LRB- Ddx5 -RRB- as a transcriptional regulator .
7729546	0	p68	37,40	Hlr1	60,64	p68	Hlr1	13207(Tax:10090)	13207(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment to chromosome 11 of mouse p68 RNA helicase gene -LRB- Hlr1 -RRB- and pseudogene -LRB- Hlr1-ps1 -RRB- .
7729546	0	p68	37,40	Hlr1-ps1	82,90	p68	Hlr1-ps1	13207(Tax:10090)	111326(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment to chromosome 11 of mouse p68 RNA helicase gene -LRB- Hlr1 -RRB- and pseudogene -LRB- Hlr1-ps1 -RRB- .
7686884	0	p68	63,66	PRKR	80,84	p68	PRKR	10657	5610	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human interferon-induced , ds-RNA activated p68 kinase gene -LRB- PRKR -RRB- to chromosome 2p21-p22 .
17960593	0	p68	0,3	Runx2	26,31	p68	Runx2	13207(Tax:10090)	12393(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	p68 -LRB- Ddx5 -RRB- interacts with Runx2 and regulates osteoblast differentiation .
20818423	0	p68	17,20	p53	82,85	p68	p53	10657	7157	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|expression expression|nmod|END_ENTITY	The RNA helicase p68 modulates expression and function of the / \ 133 isoform -LRB- s -RRB- of p53 , and is inversely associated with / \ 133p53 expression in breast_cancer .
12138179	0	p68	12,15	polymerase	37,47	p68	polymerase	10714	5422	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Role of the p68 subunit of human DNA polymerase alpha-primase in simian_virus_40 DNA replication .
3116668	0	p70	30,33	IL-2	4,8	p70	IL-2	84959	3558	Gene	Gene	chain|appos|START_ENTITY chain|compound|END_ENTITY	The IL-2 receptor beta chain -LRB- p70 -RRB- : role in mediating signals for LAK , NK , and proliferative activities .
16611854	0	p70	130,133	S6_kinase-1	144,155	p70	S6 kinase-1	84959	6198	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma and retinoic_acid_X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6_kinase-1 inhibition : role for Zf9 dephosphorylation .
23627466	0	p70	92,95	S6_kinase-1	106,117	p70	S6 kinase-1	16185(Tax:10090)	72508(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Genistein sensitizes hepatic insulin signaling and modulates lipid regulatory genes through p70 ribosomal S6_kinase-1 inhibition in high-fat-high-fructose diet-fed mice .
11134159	0	p70	42,45	S6k	46,49	p70	S6k	309	6198	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Physiological hyperinsulinemia stimulates p70 -LRB- S6k -RRB- phosphorylation in human skeletal muscle .
11170836	0	p70	29,32	S6k	33,36	p70	S6k	309	6198	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Autocrine phosphorylation of p70 -LRB- S6k -RRB- in response to acute stretch in myotubes .
2295000	0	p70	28,31	interleukin-2	47,60	p70	interleukin-2	84959	3558	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|receptor receptor|compound|END_ENTITY	Selective expression of the p70 subunit of the interleukin-2 receptor on lymphocytes from patients with infectious_mononucleosis .
1698909	0	p70	70,73	interleukin_2	28,41	p70	interleukin 2	84959	3558	Gene	Gene	chain|appos|START_ENTITY chain|compound|END_ENTITY	Increased expression of the interleukin_2 -LRB- IL-2 -RRB- receptor beta chain -LRB- p70 -RRB- on CD56 + natural killer cells after in vivo IL-2 therapy : p70 expression does not alone predict the level of intermediate affinity IL-2 binding .
26071201	0	p70S6K	0,6	focal_adhesion_kinase	23,44	p70S6K	focal adhesion kinase	72508(Tax:10090)	14083(Tax:10090)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	p70S6K is regulated by focal_adhesion_kinase and is required for Src-selective autophagy .
22065737	0	p70S6K	75,81	p70_ribosomal_protein_S6_kinase	42,73	p70S6K	p70 ribosomal protein S6 kinase	6198	6198	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Glycogen synthase kinase -LRB- GSK -RRB- -3 promotes p70_ribosomal_protein_S6_kinase -LRB- p70S6K -RRB- activity and cell proliferation .
25573956	0	p70S6K1	14,21	Pdcd4	36,41	p70S6K1	Pdcd4	72508(Tax:10090)	18569(Tax:10090)	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|END_ENTITY	Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R / IR Inhibitor in Colon_Carcinoma Cells .
12740386	0	p70S6_kinase	23,35	granulocyte_macrophage_colony-stimulating_factor	50,98	p70S6 kinase	granulocyte macrophage colony-stimulating factor	6198	1437	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Mechanism of ribosomal p70S6_kinase activation by granulocyte_macrophage_colony-stimulating_factor in neutrophils : cooperation of a MEK-related , THR421/SER424 kinase and a rapamycin-sensitive , m-TOR-related THR389 kinase .
16452250	0	p70S6_kinase	78,90	insulin-like_growth_factor-I	104,132	p70S6 kinase	insulin-like growth factor-I	72508(Tax:10090)	16000(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Thiazolidinediones inhibit insulin-like_growth_factor-i-induced activation of p70S6_kinase and suppress insulin-like_growth_factor-I tumor-promoting activity .
8527301	0	p70S6k	46,52	Erythropoietin	0,14	p70S6k	Erythropoietin	72508(Tax:10090)	13856(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Erythropoietin induces biphasic activation of p70S6k : evidence for a different regulation of early and late phase of activation .
16258737	0	p70S6k_and_4E-BP1	13,30	insulin	45,52	p70S6k and 4E-BP1	insulin	1978	3630	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Differential p70S6k_and_4E-BP1 regulation by insulin and amino_acids in vascular endothelial and smooth muscle cells .
17077083	0	p70_S6K	113,120	mammalian_target_of_rapamycin	83,112	p70 S6K	mammalian target of rapamycin	6198	2475	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian_target_of_rapamycin / p70_S6K pathway .
11705993	0	p70_S6K	115,122	ribosomal_protein_S6	78,98	p70 S6K	ribosomal protein S6	6198	6194	Gene	Gene	kinase|appos|START_ENTITY kinase|amod|END_ENTITY	The activated glucocorticoid_receptor modulates presumptive autoregulation of ribosomal_protein_S6 protein kinase , p70_S6K .
15385434	0	p70_S6_kinase	25,38	Apelin	0,6	p70 S6 kinase	Apelin	6198	8862	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Apelin -LRB- 65-77 -RRB- activates p70_S6_kinase and is mitogenic for umbilical endothelial cells .
11684675	0	p70_S6_kinase	88,101	FRAP	80,84	p70 S6 kinase	FRAP	6198	2475	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70_S6_kinase activation .
1380801	0	p70_S6_kinase	42,55	IL-2	59,63	p70 S6 kinase	IL-2	6198	3558	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Rapamycin inhibits the phosphorylation of p70_S6_kinase in IL-2 and mitogen-activated human T cells .
10567431	0	p70_S6_kinase_alpha	74,93	mammalian_target_of_rapamycin	15,44	p70 S6 kinase alpha	mammalian target of rapamycin	6198	2475	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Immunopurified mammalian_target_of_rapamycin phosphorylates and activates p70_S6_kinase_alpha in vitro .
11733037	0	p70_S6_kinase_alpha	67,86	p70_S6_kinase_beta	34,52	p70 S6 kinase alpha	p70 S6 kinase beta	6198	6199	Gene	Gene	that|nmod|START_ENTITY END_ENTITY|nmod|that	Distinct regulatory mechanism for p70_S6_kinase_beta from that for p70_S6_kinase_alpha .
11733037	0	p70_S6_kinase_beta	34,52	p70_S6_kinase_alpha	67,86	p70 S6 kinase beta	p70 S6 kinase alpha	6199	6198	Gene	Gene	START_ENTITY|nmod|that that|nmod|END_ENTITY	Distinct regulatory mechanism for p70_S6_kinase_beta from that for p70_S6_kinase_alpha .
22065737	0	p70_ribosomal_protein_S6_kinase	42,73	p70S6K	75,81	p70 ribosomal protein S6 kinase	p70S6K	6198	6198	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Glycogen synthase kinase -LRB- GSK -RRB- -3 promotes p70_ribosomal_protein_S6_kinase -LRB- p70S6K -RRB- activity and cell proliferation .
9252447	0	p70s6k	0,6	CCK	23,26	p70s6k	CCK	83840(Tax:10116)	25298(Tax:10116)	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	p70s6k is activated by CCK in rat pancreatic acini .
9445476	0	p70s6k	34,40	PDK1	44,48	p70s6k	PDK1	6198	5163	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation and activation of p70s6k by PDK1 .
26341144	0	p70s6k	176,182	mGluR5	131,137	p70s6k	mGluR5	83840(Tax:10116)	14805(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k .
24386828	0	p70s6k	58,64	rpS6	66,70	p70s6k	rpS6	83840(Tax:10116)	29304(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Swimming training enhances muscle growth and potentiates p70s6k , rpS6 protein expression in rat skeletal muscle -RSB- .
19718048	0	p72	21,24	ERalpha	35,42	p72	ERalpha	10521	2099	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	The DEAD-box protein p72 regulates ERalpha - / oestrogen-dependent transcription and cell growth , and is associated with improved survival in ERalpha-positive breast_cancer .
7522622	0	p72syk	24,30	Fc_gamma_RI	34,45	p72syk	Fc gamma RI	6850	2209	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	Protein-tyrosine kinase p72syk in Fc_gamma_RI receptor signaling .
8200459	0	p72syk	23,29	Interleukin_2	0,13	p72syk	Interleukin 2	6850	3558	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Interleukin_2 mediates p72syk activation in peripheral blood lymphocytes .
8428900	0	p72syk	24,30	thrombin	47,55	p72syk	thrombin	6850	2147	Gene	Gene	activated|nsubjpass|START_ENTITY activated|nmod|END_ENTITY	Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2 + mobilization in platelets .
17672938	0	p73	54,57	14-3-3sigma	11,22	p73	14-3-3sigma	7161	2810	Gene	Gene	-RSB-|amod|START_ENTITY Effect|nmod|-RSB- Effect|nmod|END_ENTITY	-LSB- Effect of 14-3-3sigma on transcriptional activity of p73 gene -RSB- .
14647469	0	p73	70,73	Adenosine_deaminase	0,19	p73	Adenosine deaminase	7161	100	Gene	Gene	target|amod|START_ENTITY target|nsubj|END_ENTITY	Adenosine_deaminase , a key enzyme in DNA precursors control , is a new p73 target .
11231003	0	p73	63,66	Aquaporin_3	0,11	p73	Aquaporin 3	22062(Tax:10090)	11828(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Aquaporin_3 , a glycerol and water transporter , is regulated by p73 of the p53 family .
16741250	0	p73	14,17	CD154	0,5	p73	CD154	7161	959	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	CD154 induces p73 to overcome the resistance to apoptosis of chronic_lymphocytic_leukemia cells lacking functional p53 .
15601819	0	p73	0,3	Chk1	66,70	p73	Chk1	7161	1111	Gene	Gene	induction|amod|START_ENTITY regulated|nsubjpass|induction regulated|nmod|END_ENTITY	p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2 .
19581926	0	p73	74,77	FBXO45	18,24	p73	FBXO45	7161	200933	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73 .
15678106	0	p73	44,47	Itch	29,33	p73	Itch	7161	83737	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	The ubiquitin-protein ligase Itch regulates p73 stability .
21093410	0	p73	45,48	MDM2	0,4	p73	MDM2	7161	4193	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells .
12192602	0	p73	30,33	N-myc	0,5	p73	N-myc	7161	4613	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	N-myc modulates expression of p73 in neuroblastoma .
26907686	0	p73	36,39	PCBP2	20,25	p53	PCBP2	22060(Tax:10090)	18521(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RNA-Binding Protein PCBP2 regulates p73 expression and p73-dependent antioxidant defense .
26930720	0	p73	0,3	POSTN	63,68	p73	POSTN	7161	10631	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|expression expression|compound|END_ENTITY	p73 promotes glioblastoma cell invasion by directly activating POSTN -LRB- periostin -RRB- expression .
21994467	0	p73	39,42	Pirh2	0,5	p73	Pirh2	22062(Tax:10090)	68098(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Pirh2 , a ubiquitin E3 ligase , inhibits p73 transcriptional activity by promoting its ubiquitination .
19490146	0	p73	40,43	Plk3	0,4	p73	Plk3	7161	1263	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation .
22508983	0	p73	0,3	RNPC1	31,36	p73	RNPC1	22062(Tax:10090)	56190(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	p73 expression is regulated by RNPC1 , a target of the p53 family , via mRNA stability .
20074931	0	p73	145,148	UHRF1	172,177	p73	UHRF1	7161	29128	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|nmod|END_ENTITY	Red wine polyphenols cause growth inhibition and apoptosis in acute lymphoblastic_leukaemia cells by inducing a redox-sensitive up-regulation of p73 and down-regulation of UHRF1 .
11704858	0	p73	0,3	VEGF	29,33	p73	VEGF	7161	7422	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	p73 Overexpression increases VEGF and reduces thrombospondin-1 production : implications for tumor angiogenesis .
17110958	0	p73	40,43	Yes-associated_protein_1	4,28	p73	Yes-associated protein 1	7161	10413	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	The Yes-associated_protein_1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73 .
17980704	0	p73	47,50	Yin_Yang_1	0,10	p73	Yin Yang 1	7161	7528	Gene	Gene	activity|nmod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Yin_Yang_1 induces transcriptional activity of p73 through cooperation with E2F1 .
18029729	0	p73	26,29	Yin_Yang_1	42,52	p73	Yin Yang 1	7161	7528	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Cooperative regulation of p73 promoter by Yin_Yang_1 and E2F1 .
11713281	0	p73	44,47	ZEB	30,33	p73	ZEB	22062(Tax:10090)	21417(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The transcriptional repressor ZEB regulates p73 expression at the crossroad between proliferation and differentiation .
17029218	0	p73	40,43	ZEB1	63,67	p73	ZEB1	7161	6935	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	The presence of an intronic deletion in p73 and high levels of ZEB1 alter the TAp73/DeltaTAp73 ratio in colorectal_carcinomas .
17297437	0	p73	22,25	ZNF143	0,6	p73	ZNF143	7161	7702	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ZNF143 interacts with p73 and is involved in cisplatin resistance through the transcriptional regulation of DNA repair genes .
10391249	0	p73	36,39	c-Abl	20,25	p73	c-Abl	22062(Tax:10090)	11350(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage .
10391251	0	p73	0,3	c-Abl	36,41	p73	c-Abl	7161	25	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage .
12716888	0	p73	50,53	c-Abl	13,18	p73	c-Abl	7161	25	Gene	Gene	function|amod|START_ENTITY restrains|dobj|function restrains|nsubj|Exclusion Exclusion|nmod|END_ENTITY	Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function .
12810679	0	p73	17,20	c-Abl	0,5	p73	c-Abl	7161	25	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	c-Abl stabilizes p73 by a phosphorylation-augmented interaction .
12824179	0	p73	44,47	c-Abl	0,5	p73	c-Abl	7161	25	Gene	Gene	association|nummod|START_ENTITY regulates|dobj|association regulates|nsubj|kinase kinase|amod|END_ENTITY	c-Abl tyrosine kinase selectively regulates p73 nuclear matrix association .
15175157	0	p73	58,61	c-Abl	29,34	p73	c-Abl	7161	25	Gene	Gene	function|amod|START_ENTITY regulating|dobj|function links|advcl|regulating links|dobj|activities activities|nmod|END_ENTITY	Pin1 links the activities of c-Abl and p300 in regulating p73 function .
15737644	0	p73	0,3	cyclin_B1	53,62	p73	cyclin B1	7161	891	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|transcription transcription|amod|END_ENTITY	p73 is a p53-independent , Sp1-dependent repressor of cyclin_B1 transcription .
17822668	0	p73	34,37	early_growth_response-1	75,98	p73	early growth response-1	7161	1958	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Transcriptional regulation of the p73 gene , a member of the p53 family , by early_growth_response-1 -LRB- Egr-1 -RRB- .
25972084	0	p73	160,163	mir-200a	117,125	p73	mir-200a	7161	406983	Gene	Gene	upregulating|nmod|START_ENTITY upregulating|dobj|END_ENTITY	Restin suppressed epithelial-mesenchymal transition and tumor metastasis in breast_cancer cells through upregulating mir-200a / b expression via association with p73 .
11840343	0	p73	14,17	p38	39,42	p73	p38	7161	1432	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|pathway pathway|amod|END_ENTITY	Regulation of p73 by c-Abl through the p38 MAP kinase pathway .
10049720	0	p73	27,30	p53	129,132	p73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY fibroblasts|nsubj|expression fibroblasts|nmod|level level|nmod|protein protein|compound|END_ENTITY	Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein .
10362118	0	p73	14,17	p53	50,53	p73	p53	7161	7157	Gene	Gene	Expression|nmod|START_ENTITY related|nsubj|Expression related|nmod|p53 p53|compound|END_ENTITY	Expression of p73 , a novel protein related to the p53 tumour suppressor p53 , and apoptosis in cholangiocellular_carcinoma of the liver .
10362118	0	p73	14,17	p53	72,75	p73	p53	7161	7157	Gene	Gene	Expression|nmod|START_ENTITY related|nsubj|Expression related|nmod|END_ENTITY	Expression of p73 , a novel protein related to the p53 tumour suppressor p53 , and apoptosis in cholangiocellular_carcinoma of the liver .
10408409	0	p73	18,21	p53	66,69	p73	p53	7161	7157	Gene	Gene	expression|nmod|START_ENTITY increased|nsubjpass|expression increased|nmod|lung_cancer lung_cancer|appos|independent independent|nmod|alteration alteration|compound|END_ENTITY	The expression of p73 is increased in lung_cancer , independent of p53 gene alteration .
10606650	0	p73	0,3	p53	18,21	p73	p53	7161	7157	Gene	Gene	competes|nsubj|START_ENTITY competes|nmod|END_ENTITY	p73 competes with p53 and attenuates its response in a human ovarian_cancer cell line .
10753204	0	p73	153,156	p53	196,199	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY imprinting|nmod|expression loss|nmod|imprinting related|nsubjpass|loss related|nmod|END_ENTITY	Molecular alterations of p73 in human esophageal squamous_cell_carcinomas : loss of heterozygosity occurs frequently ; loss of imprinting and elevation of p73 expression may be related to defective p53 .
10753204	0	p73	25,28	p53	196,199	p73	p53	7161	7157	Gene	Gene	alterations|nmod|START_ENTITY occurs|nsubj|alterations occurs|parataxis|related related|nmod|END_ENTITY	Molecular alterations of p73 in human esophageal squamous_cell_carcinomas : loss of heterozygosity occurs frequently ; loss of imprinting and elevation of p73 expression may be related to defective p53 .
10884390	0	p73	82,85	p53	44,47	p73	p53	7161	7157	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|mutants mutants|compound|END_ENTITY	Physical and functional interaction between p53 mutants and different isoforms of p73 .
10894779	0	p73	50,53	p53	31,34	p73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	An anti-apoptotic role for the p53 family member , p73 , during developmental neuron_death .
11034215	0	p73	27,30	p53	13,16	p73	p53	7161	7157	Gene	Gene	homologue|dobj|START_ENTITY END_ENTITY|acl|homologue	Role for the p53 homologue p73 in E2F-1-induced apoptosis .
11231003	0	p73	63,66	p53	74,77	p73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|nmod|family family|compound|END_ENTITY	Aquaporin_3 , a glycerol and water transporter , is regulated by p73 of the p53 family .
11245471	0	p73	19,22	p53	44,47	p73	p53	7161	7157	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	A possible role of p73 on the modulation of p53 level through MDM2 .
11275986	0	p73	27,30	p53	45,48	p73	p53	7161	7157	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|a a|nmod|protein protein|compound|END_ENTITY	Functional inactivation of p73 , a homolog of p53 tumor suppressor protein , by human_papillomavirus E6 proteins .
11850851	0	p73	69,72	p53	45,48	p73	p53	7161	397926(Tax:8355)	Gene	Gene	raised|nmod|START_ENTITY raised|nmod|interact interact|compound|END_ENTITY	Monoclonal antibodies raised against Xenopus p53 interact with human p73 .
12101410	0	p73	45,48	p53	0,3	p73	p53	7161	7157	Gene	Gene	N|compound|START_ENTITY expression|nmod|N induces|dobj|expression induces|nsubj|END_ENTITY	p53 induces the expression of its antagonist p73 Delta N , establishing an autoregulatory feedback loop .
12639967	0	p73	30,33	p53	18,21	p73	p53	7161	7157	Gene	Gene	homolog|dobj|START_ENTITY Regulation|acl|homolog Regulation|nmod|END_ENTITY	Regulation of the p53 homolog p73 by adenoviral oncogene E1A .
12726854	0	p73	69,72	p53	0,3	p73	p53	7161	7157	Gene	Gene	back|nmod|START_ENTITY stab|nmod|back mutations|dep|stab mutations|compound|END_ENTITY	p53 mutations and resistance to chemotherapy : A stab in the back for p73 .
12850759	0	p73	70,73	p53	1,4	p73	p53	7161	7157	Gene	Gene	-RSB-|compound|START_ENTITY back|nmod|-RSB- stab|nmod|back mutations|dep|stab mutations|compound|END_ENTITY	-LSB- p53 mutations and resistance to chemotherapy : a stab in the back for p73 ? -RSB- .
12880967	0	p73	15,18	p53	103,106	p73	p53	7161	7157	Gene	Gene	needs|xcomp|START_ENTITY needs|dep|forced forced|ccomp|induces induces|dobj|accumulation accumulation|nmod|protein protein|compound|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12880967	0	p73	15,18	p53	5,8	p73	p53	7161	7157	Gene	Gene	needs|xcomp|START_ENTITY needs|nsubj|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12880967	0	p73	45,48	p53	103,106	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY induces|nsubj|expression induces|dobj|accumulation accumulation|nmod|protein protein|compound|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12880967	0	p73	45,48	p53	5,8	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY induces|nsubj|expression forced|ccomp|induces needs|dep|forced needs|nsubj|END_ENTITY	When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein .
12934108	0	p73	0,3	p53	64,67	p73	p53	7161	7157	Gene	Gene	suppress|nsubj|START_ENTITY suppress|dobj|proliferation proliferation|nmod|cells cells|acl:relcl|express express|dobj|END_ENTITY	p73 can suppress the proliferation of cells that express mutant p53 .
14676279	0	p73	45,48	p53	25,28	p73	p53	7161	7157	Gene	Gene	overexpression|amod|START_ENTITY target|nmod|overexpression target|nsubj|response response|nmod|END_ENTITY	Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line .
14719122	0	p73	33,36	p53	54,57	p73	p53	7161	7157	Gene	Gene	gene|amod|START_ENTITY alterations|nmod|gene value|nmod|alterations value|acl|related related|nmod|END_ENTITY	Clinical value of alterations in p73 gene , related to p53 at 1p36 , in human hepatocellular_carcinoma .
14720173	0	p73	18,21	p53	4,7	p73	p53	7161	7157	Gene	Gene	accumulates|amod|START_ENTITY homologue|dobj|accumulates END_ENTITY|acl|homologue	The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer_disease brain .
15302867	0	p73	65,68	p53	50,53	p73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	homologue|appos|START_ENTITY homologue|compound|END_ENTITY	c-Jun regulates the stability and activity of the p53 homologue , p73 .
16271066	0	p73	0,3	p53	21,24	p73	p53	7161	7157	Gene	Gene	START_ENTITY|appos|member member|compound|END_ENTITY	p73 , a sophisticated p53 family member in the cancer world .
16481734	0	p73	50,53	p53	62,65	p73	p53	7161	7157	Gene	Gene	beta|amod|START_ENTITY beta|appos|homologue homologue|compound|END_ENTITY	Therapeutic potential of an adenovirus expressing p73 beta , a p53 homologue , against human_papilloma_virus_positive_cervical_cancer in vitro and in vivo .
16741250	0	p73	14,17	p53	115,118	p73	p53	7161	7157	Gene	Gene	START_ENTITY|xcomp|overcome overcome|nmod|apoptosis apoptosis|nmod|cells cells|acl|lacking lacking|dobj|END_ENTITY	CD154 induces p73 to overcome the resistance to apoptosis of chronic_lymphocytic_leukemia cells lacking functional p53 .
16815295	0	p73	0,3	p53	84,87	p73	p53	7161	7157	Gene	Gene	confer|nsubj|START_ENTITY confer|xcomp|cisplatin cisplatin|advcl|blocking blocking|dobj|END_ENTITY	p73 and MDM2 confer the resistance of epidermoid_carcinoma to cisplatin by blocking p53 .
16849542	0	p73	0,3	p53	36,39	p73	p53	7161	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|transcription transcription|compound|END_ENTITY	p73 or p53 directly regulates human p53 transcription to maintain cell cycle checkpoints .
17169329	0	p73	120,123	p53	141,144	p73	p53	7161	7157	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	The expression of phosphatidic_acid_phosphatase_2a , which hydrolyzes lipids to generate diacylglycerol , is regulated by p73 , a member of the p53 family .
17707235	0	p73	0,3	p53	70,73	p73	p53	7161	7157	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|nmod|absence absence|nmod|END_ENTITY	p73 suppresses polyploidy and aneuploidy in the absence of functional p53 .
17761206	0	p73	35,38	p53	14,17	p73	p53	7161	7157	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of p53 and its homolog , p73 , in HPV DNA positive oesophageal_squamous_cell_carcinomas .
17822668	0	p73	34,37	p53	60,63	p73	p53	7161	7157	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|appos|member member|nmod|family family|compound|END_ENTITY	Transcriptional regulation of the p73 gene , a member of the p53 family , by early_growth_response-1 -LRB- Egr-1 -RRB- .
18026135	0	p73	0,3	p53	71,74	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY modulates|nsubj|expression modulates|dobj|presence presence|nmod|carcinogenesis carcinogenesis|amod|complex complex|nmod|sequence sequence|nummod|END_ENTITY	p73 expression modulates p63 and Mdm2 protein presence in complex with p53 family-specific DNA target sequence in squamous cell carcinogenesis .
18260640	0	p73	4,7	p53	103,106	p73	p53	7161	7157	Gene	Gene	domain|amod|START_ENTITY displays|nsubj|domain displays|advmod|relative relative|nmod|homologue homologue|appos|END_ENTITY	The p73 DNA binding domain displays enhanced stability relative to its homologue , the tumor suppressor p53 , and exhibits cooperative DNA binding .
18313527	0	p73	0,3	p53	82,85	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY correlates|nsubj|expression correlates|nmod|apoptosis apoptosis|nmod|lack lack|nmod|response response|compound|END_ENTITY	p73 protein expression correlates with radiation-induced apoptosis in the lack of p53 response to radiation_therapy for cervical_cancer .
18469517	0	p73	50,53	p53	124,127	p73	p53	7161	7157	Gene	Gene	variants|nmod|START_ENTITY Involvement|nmod|variants Involvement|dep|comparison comparison|nmod|mutations mutations|compound|END_ENTITY	Involvement of N-terminally truncated variants of p73 , deltaTAp73 , in head_and_neck_squamous_cell_cancer : a comparison with p53 mutations .
18801697	0	p73	26,29	p53	65,68	p73	p53	7161	7157	Gene	Gene	prospects|nmod|START_ENTITY prospects|dep|rising rising|nmod|shadow shadow|nmod|END_ENTITY	Therapeutic prospects for p73 and p63 : rising from the shadow of p53 .
20160513	0	p73	0,3	p53	50,53	p73	p53	7161	7157	Gene	Gene	protein|amod|START_ENTITY protein|dep|relative relative|nmod|END_ENTITY	p73 tumor suppressor protein : a close relative of p53 not only in structure but also in anti-cancer approach ?
20305378	0	p73	33,36	p53	16,19	p73	p53	7161	7157	Gene	Gene	results|compound|START_ENTITY signaling|nmod|results Inactivation|acl|signaling Inactivation|nmod|END_ENTITY	Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis .
20675383	0	p73	103,106	p53	45,48	p73	p53	7161	7157	Gene	Gene	p53|nmod|START_ENTITY switchover|nmod|p53 leads|xcomp|switchover leads|nsubj|Gain Gain|nmod|adaptation adaptation|amod|due due|nmod|impairment impairment|compound|END_ENTITY	Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute_myeloid_leukemia cells .
20812030	0	p73	90,93	p53	37,40	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY activating|dobj|expression induces|advcl|activating induces|dobj|apoptosis apoptosis|nmod|cells cells|nummod|END_ENTITY	Mdm2 inhibition induces apoptosis in p53 deficient human colon_cancer cells by activating p73 - and E2F1-mediated expression of PUMA and Siva-1 .
21214929	0	p73	138,141	p53	69,72	p73	p53	7161	7157	Gene	Gene	cells|nmod|START_ENTITY cells|nummod|END_ENTITY	a-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant , triple-negative human breast_cancer cells via activating p73 .
21241554	0	p73	21,24	p53	63,66	p73	p53	7161	7157	Gene	Gene	gene|amod|START_ENTITY Effect|nmod|gene Effect|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of exogenous p73 gene on chemosensitivity of wild-type p53 human lung_adenocarcinoma cell A549 -RSB- .
21368881	0	p73	0,3	p53	132,135	p73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	results|amod|START_ENTITY progenitors|nsubj|results progenitors|nmod|END_ENTITY	p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53 .
21976716	0	p73	0,3	p53	58,61	p73	p53	7161	7157	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|nmod|Arg72Pro Arg72Pro|nummod|END_ENTITY	p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility : a meta-analysis of the literature .
22076304	0	p73	79,82	p53	60,63	p73	p53	7161	7157	Gene	Gene	member|appos|START_ENTITY member|compound|END_ENTITY	Pleomorphic_adenoma_gene-like_2 regulates expression of the p53 family member , p73 , and induces cell cycle block and apoptosis in human promonocytic U937 cells .
22497596	0	p73	27,30	p53	8,11	p73	p53	7161	7157	Gene	Gene	members|amod|START_ENTITY members|compound|END_ENTITY	Role of p53 family members p73 and p63 in human hematological_malignancies .
22508983	0	p73	0,3	p53	54,57	p73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|RNPC1 RNPC1|appos|target target|nmod|family family|compound|END_ENTITY	p73 expression is regulated by RNPC1 , a target of the p53 family , via mRNA stability .
22952705	0	p73	29,32	p53	0,3	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|inactivation inactivation|compound|END_ENTITY	p53 inactivation upregulates p73 expression through E2F-1 mediated transcription .
24247721	0	p73	83,86	p53	30,33	p73	p53	7161	7157	Gene	Gene	upregulating|dobj|START_ENTITY rescues|advcl|upregulating rescues|dobj|signaling signaling|compound|END_ENTITY	Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53 .
24874608	0	p73	13,16	p53	22,25	p73	p53	7161	7157	Gene	Gene	couples|dobj|START_ENTITY couples|nmod|END_ENTITY	AMPK couples p73 with p53 in cell fate decision .
26294215	0	p73	107,110	p53	148,151	p73	p53	7161	7157	Gene	Gene	Activation|compound|START_ENTITY Activation|nmod|Mutant Mutant|nummod|END_ENTITY	Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal_Cancer via p73 Activation and Degradation of Mutant p53 .
26294215	0	p73	107,110	p53	33,36	p73	p53	7161	7157	Gene	Gene	Activation|compound|START_ENTITY Colorectal_Cancer|nmod|Activation Restores|nmod|Colorectal_Cancer Restores|dobj|Signaling Signaling|nummod|END_ENTITY	Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal_Cancer via p73 Activation and Degradation of Mutant p53 .
26527653	0	p73	31,34	p53	0,3	p73	p53	22062(Tax:10090)	22060(Tax:10090)	Gene	Gene	That|nmod|START_ENTITY Dominates|dobj|That Dominates|nsubj|Activity Activity|compound|END_ENTITY	p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis .
27074052	0	p73	14,17	p53	131,134	p73	p53	7161	7157	Gene	Gene	expression|amod|START_ENTITY Modulation|nmod|expression induces|nsubj|Modulation induces|nmod|mantle_cell_lymphoma mantle_cell_lymphoma|nmod|status status|compound|END_ENTITY	Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle_cell_lymphoma independent of p53 status .
9797131	0	p73	0,3	p53	23,26	p73	p53	7161	7157	Gene	Gene	START_ENTITY|appos|gene gene|acl|related related|nmod|END_ENTITY	p73 , a gene related to p53 , is not mutated in esophageal_carcinomas .
9823311	0	p73	31,34	p53	69,72	p73	p53	7161	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|genes genes|compound|END_ENTITY	The potential tumor suppressor p73 differentially regulates cellular p53 target genes .
9891077	0	p73	0,3	p53	43,46	p73	p53	7161	7157	Gene	Gene	function|amod|START_ENTITY inhibited|nsubjpass|function inhibited|nmod|mutants mutants|compound|END_ENTITY	p73 function is inhibited by tumor-derived p53 mutants in mammalian cells .
11027640	0	p73	59,62	p73	9,12	p73	p73	7161	7161	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid_leukemia .
11027640	0	p73	9,12	p73	59,62	p73	p73	7161	7161	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Enhanced p73 expression during differentiation and complex p73 isoforms in myeloid_leukemia .
17169329	0	p73	120,123	phosphatidic_acid_phosphatase_2a	18,50	p73	phosphatidic acid phosphatase 2a	7161	8611	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	The expression of phosphatidic_acid_phosphatase_2a , which hydrolyzes lipids to generate diacylglycerol , is regulated by p73 , a member of the p53 family .
15723830	0	p73	88,91	protein_kinase_A_catalytic_subunit_beta	18,57	p73	protein kinase A catalytic subunit beta	7161	5567	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of protein_kinase_A_catalytic_subunit_beta as a novel binding partner of p73 and regulation of p73 function .
10544233	0	p75	68,71	FAP-1	56,61	p75	FAP-1	7133	5783	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Functional interaction of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- with p75 -LRB- NTR -RRB- and their effect on NF-kappaB activation .
10544233	0	p75	68,71	Fas-associated_phosphatase-1	26,54	p75	Fas-associated phosphatase-1	7133	5783	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of Fas-associated_phosphatase-1 -LRB- FAP-1 -RRB- with p75 -LRB- NTR -RRB- and their effect on NF-kappaB activation .
15383581	0	p75	38,41	IL-2	65,69	p75	IL-2	3560	3558	Gene	Gene	START_ENTITY|nmod|costimulator costimulator|nmod|induction induction|compound|END_ENTITY	Critical role of TNF receptor type-2 -LRB- p75 -RRB- as a costimulator for IL-2 induction and T cell survival : a functional link to CD28 .
2080985	0	p75	73,76	IL-2	115,119	p75	IL-2	21938(Tax:10090)	16183(Tax:10090)	Gene	Gene	form|amod|START_ENTITY form|nmod|receptor receptor|nmod|END_ENTITY	A regulatory role for the soluble IL-2 receptor via competition with the p75 cell-surface form of the receptor for IL-2 .
2080985	0	p75	73,76	IL-2	34,38	p75	IL-2	21938(Tax:10090)	16183(Tax:10090)	Gene	Gene	form|amod|START_ENTITY role|nmod|form role|nmod|receptor receptor|compound|END_ENTITY	A regulatory role for the soluble IL-2 receptor via competition with the p75 cell-surface form of the receptor for IL-2 .
2106566	0	p75	71,74	IL-2	15,19	p75	IL-2	3560	3558	Gene	Gene	phosphorylation|nmod|START_ENTITY Interleukin_2|dep|phosphorylation Interleukin_2|appos|END_ENTITY	Interleukin_2 -LRB- IL-2 -RRB- - induced tyrosine phosphorylation of IL-2_receptor p75 .
2469650	0	p75	87,90	IL-2	42,46	p75	IL-2	21938(Tax:10090)	16183(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY sites|nmod|complex sites|amod|binding binding|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
8318457	0	p75	34,37	IL-2	12,16	p75	IL-2	3560	3558	Gene	Gene	molecules|amod|START_ENTITY interaction|nmod|molecules interaction|nsubj|role role|nmod|END_ENTITY	The role of IL-2 interaction with p75 and p55 receptor molecules in the stimulation of cell proliferation .
8397255	0	p75	189,192	IL-2	55,59	p75	IL-2	7133	3558	Gene	Gene	chimera|appos|START_ENTITY production|nmod|chimera Induction|nmod|production Induction|nmod|immunotherapy immunotherapy|compound|END_ENTITY	Induction of circulating and erythrocyte-bound IL-8 by IL-2 immunotherapy and suppression of its in vitro production by IL-1_receptor_antagonist and soluble tumor necrosis factor receptor -LRB- p75 -RRB- chimera .
1580147	0	p75	28,31	IL-2_receptor	14,27	p75	IL-2 receptor	3560	3560	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of IL-2_receptor / p75 on lymphocytes from patients with rubella .
2469650	0	p75	87,90	IL-2_receptor	67,80	p75	IL-2 receptor	21938(Tax:10090)	16184(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
1888707	0	p75	34,37	IL-4	0,4	p75	IL-4	3560	3565	Gene	Gene	down-regulates|dobj|START_ENTITY down-regulates|nsubj|END_ENTITY	IL-4 down-regulates IL-2_receptor p75 by accelerating its endocytosis .
2106566	0	p75	71,74	Interleukin_2	0,13	p75	Interleukin 2	3560	3558	Gene	Gene	phosphorylation|nmod|START_ENTITY END_ENTITY|dep|phosphorylation	Interleukin_2 -LRB- IL-2 -RRB- - induced tyrosine phosphorylation of IL-2_receptor p75 .
16735438	0	p75	29,32	JPO2	79,83	p75	JPO2	11168	55536	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin .
7473570	0	p75	96,99	NGF	100,103	p75	NGF	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
7473570	0	p75	96,99	NGF	71,74	p75	NGF	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY nerve_growth_factor|nmod|receptor nerve_growth_factor|appos|END_ENTITY	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
9622009	0	p75	9,12	NGF	68,71	p75	NGF	18053(Tax:10090)	18049(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY Level|nmod|expression modulated|nsubjpass|Level modulated|nmod|level level|compound|END_ENTITY	Level of p75 receptor expression in sensory ganglia is modulated by NGF level in the target tissue .
19041213	0	p75	43,46	NGFR	47,51	p75	NGFR	11168	4804	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Patterns of expression and function of the p75 -LRB- NGFR -RRB- protein in pancreatic_cancer cells and tumours .
21178583	0	p75	6,9	NGFR	0,4	p75	NGFR	7133	4804	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	NGFR -LRB- p75 -RRB- expression in cutaneous scars ; Further evidence for a potential pitfall in evaluation of reexcision scars of cutaneous neoplasms , in particular desmoplastic_melanoma .
9605523	0	p75	39,42	NGF_receptor	25,37	p75	NGF receptor	3560	4804	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of the low-affinity NGF_receptor -LRB- p75 -RRB- in survival of retinal bipolar cells .
10773744	5	p75	1016,1019	NTR	1020,1023	p75	NTR	11168	4923	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	For this purpose , we studied paraffin sections of the SON in 32 postmortem brains of control patients ranging in age from 29 to 94 years with an anti-p75 -LRB- NTR -RRB- antibody and determined the area of p75 -LRB- NTR -RRB- immunoreactivity per neuron using an image analysis system .
11042591	0	p75	11,14	NTR	15,18	p75	NTR	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Absence of p75 -LRB- NTR -RRB- expression reduces nerve_growth_factor immunolocalization in cholinergic septal neurons .
11398197	0	p75	42,45	NTR	46,49	p75	NTR	7133	4923	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Molecular characterization of the loss of p75 -LRB- NTR -RRB- expression in human prostate_tumor cells .
11451944	0	p75	22,25	NTR	26,29	p75	NTR	7133	4923	Gene	Gene	apoptotic|amod|START_ENTITY apoptotic|appos|END_ENTITY	Characterization of a p75 -LRB- NTR -RRB- apoptotic signaling pathway using a novel cellular model .
11992464	0	p75	14,17	NTR	18,21	p75	NTR	11168	4923	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Dual role for p75 -LRB- NTR -RRB- signaling in survival and cell death : can intracellular mediators provide an explanation ?
18055214	0	p75	45,48	NTR	49,52	p75	NTR	11168	4923	Gene	Gene	fragment|nmod|START_ENTITY Palmitoylation|nmod|fragment regulates|nsubj|Palmitoylation regulates|dep|END_ENTITY	Palmitoylation of the C-terminal fragment of p75 -LRB- NTR -RRB- regulates death signaling and is required for subsequent cleavage by gamma-secretase .
18196575	0	p75	4,7	NTR	8,11	p75	NTR	7133	4923	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The p75 NTR neurotrophin receptor is a tumor suppressor in human and murine retinoblastoma development .
18378044	0	p75	45,48	NTR	49,52	p75	NTR	11168	4923	Gene	Gene	switch|amod|START_ENTITY switch|appos|END_ENTITY	Egr-1 and Hipk2 are required for the TrkA to p75 -LRB- NTR -RRB- switch that occurs downstream of IGF1-R .
18602709	0	p75	0,3	NTR	4,7	p75	NTR	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	p75 -LRB- NTR -RRB- activation of NF-kappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells .
19156869	0	p75	0,3	NTR	4,7	p75	NTR	7133	4923	Gene	Gene	expression|nummod|START_ENTITY expression|compound|END_ENTITY	p75 NTR expression is induced in isolated neurons of the penumbra after ischemia by cortical_devascularization .
19156869	14	p75	1669,1672	NTR	1673,1676	p75	NTR	7133	4923	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	In primary neuronal culture , it is clear that excitotoxicity and Sp1 are involved in induction of p75 -LRB- NTR -RRB- expression , although , in vivo , some additional mechanisms are likely to be involved in the control of p75 -LRB- NTR -RRB- expression in specific neurons in vivo .
19156869	5	p75	663,666	NTR	667,670	p75	NTR	7133	4923	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	In this study , we analyzed the spatiotemporal profile of p75 -LRB- NTR -RRB- expression after an ischemic_lesion induced by cortical_devascularization -LRB- CD -RRB- .
20659559	0	p75	124,127	NTR	128,131	p75	NTR	11168	4923	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	LINGO-1-mediated inhibition of oligodendrocyte differentiation does not require the leucine-rich repeats and is reversed by p75 -LRB- NTR -RRB- antagonists .
21658451	0	p75	0,3	NTR	4,7	p75	NTR	11168	4923	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p75 -LRB- NTR -RRB- expression and nuclear localization of p75 -LRB- NTR -RRB- intracellular_domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation .
21658451	0	p75	48,51	NTR	52,55	p75	NTR	11168	4923	Gene	Gene	intracellular_domain|amod|START_ENTITY intracellular_domain|appos|END_ENTITY	p75 -LRB- NTR -RRB- expression and nuclear localization of p75 -LRB- NTR -RRB- intracellular_domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation .
26057084	0	p75	24,27	NTR	28,31	p75	NTR	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Merlin status regulates p75 -LRB- NTR -RRB- expression and apoptotic signaling in Schwann cells following nerve_injury .
26119933	0	p75	32,35	NTR	63,66	p75	NTR	7133	4923	Gene	Gene	receptor|amod|START_ENTITY mediated|nmod|receptor Glioma_invasion|acl|mediated Glioma_invasion|appos|p75 p75|appos|END_ENTITY	Glioma_invasion mediated by the p75 neurotrophin receptor -LRB- p75 -LRB- NTR -RRB- / CD271 -RRB- requires regulated interaction with PDLIM1 .
26297037	0	p75	52,55	NTR	56,59	p75	NTR	7133	4923	Gene	Gene	Upregulation|compound|START_ENTITY Upregulation|appos|END_ENTITY	SORT1 Mutation Resulting in Sortilin Deficiency and p75 -LRB- NTR -RRB- Upregulation in a Family With Essential_Tremor .
27047921	0	p75	29,32	NTR	33,36	p75	NTR	11168	4923	Gene	Gene	SOX10/CD271|dep|START_ENTITY SOX10/CD271|appos|END_ENTITY	Coexpression of SOX10/CD271 -LRB- p75 -LRB- NTR -RRB- -RRB- and b-Galactosidase in Large to Giant Congenital Melanocytic Nevi of Pediatric Patients .
10713062	0	p75	68,71	Nerve_growth_factor	0,19	p75	Nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY kappaB|nmod|receptor activation|nmod|kappaB activation|amod|END_ENTITY	Nerve_growth_factor activation of nuclear factor kappaB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells .
11746763	0	p75	33,36	Nerve_growth_factor	0,19	p75	Nerve growth factor	11168	4803	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Nerve_growth_factor signaling of p75 induces differentiation and ceramide-mediated apoptosis in Schwann cells cultured from degenerating nerves .
11818506	0	p75	95,98	Nerve_growth_factor	0,19	p75	Nerve growth factor	7133	4803	Gene	Gene	lines|nmod|START_ENTITY expression|nmod|lines D|dep|expression regulates|dobj|D regulates|nsubj|END_ENTITY	Nerve_growth_factor regulates dopamine D -LRB- 2 -RRB- receptor expression in prolactinoma cell lines via p75 -LRB- NGFR -RRB- - mediated activation of nuclear_factor-kappaB .
19229990	0	p75	67,70	Nerve_growth_factor	0,19	p75	Nerve growth factor	7133	4803	Gene	Gene	receptor|amod|START_ENTITY astrocytes|nmod|receptor proliferation|nmod|astrocytes attenuates|dobj|proliferation attenuates|nsubj|END_ENTITY	Nerve_growth_factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor .
9061691	0	p75	49,52	Nerve_growth_factor	0,19	p75	Nerve growth factor	18053(Tax:10090)	18049(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|dobj|production	Nerve_growth_factor production and expression of p75 by Schwann cells and neurofibroblasts in response to M. _ leprae infection and macrophage secretory products .
9466406	0	p75	128,131	Nerve_growth_factor	0,19	p75	Nerve growth factor	18053(Tax:10090)	18049(Tax:10090)	Gene	Gene	neurons|nmod|START_ENTITY sites|nmod|neurons expression|nmod|sites regulates|dobj|expression regulates|nsubj|END_ENTITY	Nerve_growth_factor regulates the expression of bradykinin binding sites on adult sensory neurons via the neurotrophin receptor p75 .
9835221	0	p75	95,98	Nerve_growth_factor	0,19	p75	Nerve growth factor	18053(Tax:10090)	18049(Tax:10090)	Gene	Gene	lacking|dobj|START_ENTITY mice|acl|lacking evokes|nmod|mice evokes|nsubj|END_ENTITY	Nerve_growth_factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75 .
26120963	0	p75	35,38	TGF-b	62,67	p75	TGF-b	18053(Tax:10090)	21803(Tax:10090)	Gene	Gene	controls|amod|START_ENTITY END_ENTITY|nsubj|controls	Nuclear pore complex remodeling by p75 -LRB- NTR -RRB- cleavage controls TGF-b signaling and astrocyte functions .
23526821	0	p75	159,162	TNF	155,158	p75	TNF	7133	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like_graft-versus-host_disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor .
7706751	0	p75	96,99	TNF	100,103	p75	TNF	7133	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptor .
8381414	0	p75	59,62	TNF	23,26	p75	TNF	7133	7124	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|Tumor_necrosis_factor Tumor_necrosis_factor|appos|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- up-regulates the expression of p75 but not p55 TNF receptors , and both receptors mediate , independently of each other , up-regulation of transforming_growth_factor_alpha and epidermal_growth_factor_receptor mRNA .
22371757	0	p75	19,22	TNF-a	23,28	p75	TNF-a	7133	7124	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Do soluble p55 and p75 TNF-a receptor concentrations play a role in women with primary_sterility ?
10385602	0	p75	54,57	TNF-alpha	90,99	p75	TNF-alpha	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY downregulate|nsubj|receptors downregulate|dobj|activity activity|amod|END_ENTITY	Soluble tumor necrosis factor -LRB- TNF -RRB- receptors p55 and p75 and interleukin-10 downregulate TNF-alpha activity during the lung response to silica particles in NMRI mice .
12370348	0	p75	20,23	TNF-alpha	24,33	p75	TNF-alpha	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway_hyperresponsiveness by gamma delta T cells .
12598326	0	p75	28,31	TNF-alpha	32,41	p75	TNF-alpha	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|amod|END_ENTITY	Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen_activator_inhibitor-1 .
18928394	0	p75	44,47	TNF-alpha	34,43	p75	TNF-alpha	7133	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Early evolution of plasma soluble TNF-alpha p75 receptor as a marker of progression in treated HIV-infected patients .
8974008	0	p75	66,69	TNF-alpha	124,133	p75	TNF-alpha	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|p55 p55|nmod|END_ENTITY	In vitro comparison of inhibiting ability of soluble TNF receptor p75 -LRB- TBP_II -RRB- vs. soluble TNF receptor p55 -LRB- TBP_I -RRB- against TNF-alpha and TNF-beta .
11196666	0	p75	38,41	TNFR2	31,36	p75	TNFR2	7133	7133	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A bi-allelic VNTR in the human TNFR2 -LRB- p75 -RRB- gene promoter .
8300617	0	p75	58,61	Tumor_necrosis_factor	0,21	p75	Tumor necrosis factor	7133	7124	Gene	Gene	receptor|amod|START_ENTITY selective|nmod|receptor induces|dobj|selective induces|nsubj|END_ENTITY	Tumor_necrosis_factor induces a selective shedding of its p75 receptor from human neutrophils .
8381414	0	p75	59,62	Tumor_necrosis_factor	0,21	p75	Tumor necrosis factor	7133	7124	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Tumor_necrosis_factor -LRB- TNF -RRB- up-regulates the expression of p75 but not p55 TNF receptors , and both receptors mediate , independently of each other , up-regulation of transforming_growth_factor_alpha and epidermal_growth_factor_receptor mRNA .
15337528	0	p75	61,64	c-Cbl	0,5	p75	c-Cbl	11168	867	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination .
1430108	0	p75	27,30	interleukin-2	31,44	p75	interleukin-2	3560	3558	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Expression of a functional p75 interleukin-2 receptor on lung lymphocytes from patients with human_immunodeficiency_virus_type_1 _ -LRB- HIV-1 -RRB- _ infection .
1581584	0	p75	49,52	interleukin-2	67,80	p75	interleukin-2	3560	3558	Gene	Gene	expression|amod|START_ENTITY expression|nmod|receptors receptors|compound|END_ENTITY	Phorbol_esters up-regulate p55 and down-regulate p75 expression of interleukin-2 receptors in human T cells .
7509162	0	p75	133,136	interleukin-2	145,158	p75	interleukin-2	3560	3558	Gene	Gene	_|appos|START_ENTITY _|nmod|receptor receptor|compound|END_ENTITY	Inhibition of lymphokine-activated killer cells by human pulmonary macrophages : discordance between up-regulation of the beta_chain _ -LRB- p75 -RRB- of the interleukin-2 receptor on CD56 + cells and limited response to interleukin-2 .
2146981	0	p75	52,55	interleukin-2_receptor	67,89	p75	interleukin-2 receptor	3560	3559	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Cell membrane expression and functional role of the p75 subunit of interleukin-2_receptor in lymphoproliferative_disease_of_granular_lymphocytes .
1394125	0	p75	38,41	interleukin_2	42,55	p75	interleukin 2	3560	3558	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression and functional role of the p75 interleukin_2 receptor chain on leukemic hairy_cells .
1691679	0	p75	113,116	interleukin_2	34,47	p75	interleukin 2	3560	3558	Gene	Gene	receptor|amod|START_ENTITY interleukin_2|nmod|receptor respond|xcomp|interleukin_2 respond|nsubj|cells cells|acl|activated activated|nmod|treatment treatment|amod|END_ENTITY	Natural killer cells activated by interleukin_2 treatment in vivo respond to interleukin_2 primarily through the p75 receptor and maintain the p55 -LRB- TAC -RRB- negative phenotype .
1691679	0	p75	113,116	interleukin_2	77,90	p75	interleukin 2	3560	3558	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Natural killer cells activated by interleukin_2 treatment in vivo respond to interleukin_2 primarily through the p75 receptor and maintain the p55 -LRB- TAC -RRB- negative phenotype .
1831304	0	p75	53,56	interleukin_2	18,31	p75	interleukin 2	3560	3558	Gene	Gene	chain|appos|START_ENTITY chain|amod|END_ENTITY	Expression of the interleukin_2 receptor beta chain -LRB- p75 -RRB- in renal transplantation -- applicability of anti-interleukin-2_receptor_beta chain monoclonal antibody .
2319807	0	p75	32,35	interleukin_2	53,66	p75	interleukin 2	3560	3558	Gene	Gene	component|amod|START_ENTITY component|nmod|receptor receptor|amod|END_ENTITY	Human B lymphocytes express the p75 component of the interleukin_2 receptor .
3110786	0	p75	4,7	interleukin_2	36,49	p75	interleukin 2	3560	3558	Gene	Gene	peptide|amod|START_ENTITY expressed|nsubjpass|peptide expressed|dep|receptor receptor|nmod|END_ENTITY	The p75 peptide is the receptor for interleukin_2 expressed on large granular lymphocytes and is responsible for the interleukin_2 activation of these cells .
9816306	0	p75	94,97	interleukin_2	17,30	p75	interleukin 2	3560	3558	Gene	Gene	chimera|compound|START_ENTITY necrosis|dobj|chimera necrosis|nsubj|trial trial|nmod|END_ENTITY	Phase I trial of interleukin_2 in combination with the soluble tumor necrosis factor receptor p75 IgG chimera .
2037012	0	p75	92,95	interleukin_2_receptor	96,118	p75	interleukin 2 receptor	3560	3559	Gene	Gene	subunit|amod|START_ENTITY subunit|amod|END_ENTITY	Human eosinophils from hypereosinophilic patients spontaneously express the p55 but not the p75 interleukin_2_receptor subunit .
2833327	0	p75	22,25	interleukin_2_receptor	37,59	p75	interleukin 2 receptor	3560	3559	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The expression of the p75 subunit of interleukin_2_receptor in Tac negative leukemic cells of two patients with large_granular_lymphocytic_leukemia .
1707657	0	p75	60,63	interleukin_2_receptor_beta	31,58	p75	interleukin 2 receptor beta	3560	3560	Gene	Gene	chain|appos|START_ENTITY chain|amod|END_ENTITY	Differential expression of the interleukin_2_receptor_beta -LRB- p75 -RRB- chain on human peripheral blood natural killer subsets .
12028822	0	p75	58,61	low-affinity_nerve_growth_factor_receptor	72,113	p75	low-affinity nerve growth factor receptor	11168	4804	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Oxidative stress modulates tyrosine kinase receptor A and p75 receptor -LRB- low-affinity_nerve_growth_factor_receptor -RRB- expression in SHSY5Y neuroblastoma cells .
10888742	0	p75	96,99	nerve_growth_factor	10,29	p75	nerve growth factor	18053(Tax:10090)	18049(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY affected|nmod|presence affected|nsubjpass|Levels Levels|nmod|END_ENTITY	Levels of nerve_growth_factor and neurotrophin-3 are affected differentially by the presence of p75 in sympathetic neurons in vivo .
11042591	0	p75	11,14	nerve_growth_factor	39,58	p75	nerve growth factor	18053(Tax:10090)	18049(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Absence|nmod|expression reduces|nsubj|Absence reduces|dobj|immunolocalization immunolocalization|compound|END_ENTITY	Absence of p75 -LRB- NTR -RRB- expression reduces nerve_growth_factor immunolocalization in cholinergic septal neurons .
11435417	0	p75	49,52	nerve_growth_factor	107,126	p75	nerve growth factor	7133	4803	Gene	Gene	receptors|compound|START_ENTITY domains|nmod|receptors regulate|nsubj|domains regulate|xcomp|binding binding|nmod|END_ENTITY	The cytoplasmic and transmembrane domains of the p75 and Trk_A receptors regulate high affinity binding to nerve_growth_factor .
12671996	0	p75	117,120	nerve_growth_factor	31,50	p75	nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY pathway|nmod|receptor dependent|nmod|pathway dependent|nsubj|arrest arrest|nmod|cells cells|nmod|END_ENTITY	Growth arrest of PC12 cells by nerve_growth_factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor .
1424101	0	p75	37,40	nerve_growth_factor	148,167	p75	nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY density|nmod|receptors density|nmod|antibodies antibodies|nmod|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat spinal cord as a function of age and treatment with antibodies to nerve_growth_factor .
1424101	0	p75	37,40	nerve_growth_factor	41,60	p75	nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat spinal cord as a function of age and treatment with antibodies to nerve_growth_factor .
1446237	0	p75	37,40	nerve_growth_factor	142,161	p75	nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY density|nmod|receptors density|nmod|antibodies antibodies|nmod|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat brain as a function of age and treatment with antibodies to nerve_growth_factor .
1446237	0	p75	37,40	nerve_growth_factor	41,60	p75	nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Distribution and relative density of p75 nerve_growth_factor receptors in the rat brain as a function of age and treatment with antibodies to nerve_growth_factor .
15131306	0	p75	81,84	nerve_growth_factor	13,32	p75	nerve growth factor	7133	4803	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubj|Structure Structure|nmod|END_ENTITY	Structure of nerve_growth_factor complexed with the shared neurotrophin receptor p75 .
16763091	0	p75	125,128	nerve_growth_factor	129,148	p75	nerve growth factor	7133	4803	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Penta-acetyl_geniposide induce apoptosis in C6 glioma cells by modulating the activation of neutral_sphingomyelinase-induced p75 nerve_growth_factor receptor and protein kinase Cdelta pathway .
19210757	0	p75	62,65	nerve_growth_factor	33,52	p75	nerve growth factor	3560	4803	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|receptor receptor|compound|END_ENTITY	Localization of the low-affinity nerve_growth_factor receptor p75 in human limbal epithelial cells .
7473570	0	p75	96,99	nerve_growth_factor	50,69	p75	nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|nmod|receptor	Kynurenic_acid derivatives inhibit the binding of nerve_growth_factor -LRB- NGF -RRB- to the low-affinity p75 NGF receptor .
8614802	0	p75	92,95	nerve_growth_factor	38,57	p75	nerve growth factor	24596(Tax:10116)	310738(Tax:10116)	Gene	Gene	Selective|nmod|START_ENTITY Selective|nmod|END_ENTITY	Selective activation of NF-kappa B by nerve_growth_factor through the neurotrophin receptor p75 .
14699954	0	p75	4,7	neurotrophin	8,20	p75	neurotrophin	11168	627	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The p75 neurotrophin receptor : multiple interactors and numerous functions .
18171948	0	p75	0,3	neurotrophin	4,16	p75	neurotrophin	3560	627	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol_4 ,5 - bisphosphate .
18289033	0	p75	29,32	neurotrophin	33,45	p75	neurotrophin	7133	627	Gene	Gene	functions|amod|START_ENTITY functions|compound|END_ENTITY	Small molecule modulation of p75 neurotrophin receptor functions .
19067488	0	p75	101,104	neurotrophin	105,117	p75	neurotrophin	11168	627	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor .
19229990	0	p75	67,70	neurotrophin	71,83	p75	neurotrophin	7133	627	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Nerve_growth_factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor .
19376068	0	p75	18,21	neurotrophin	22,34	p75	neurotrophin	7133	627	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers .
23260665	0	p75	57,60	neurotrophin	22,34	p75	neurotrophin	7133	627	Gene	Gene	receptor|amod|START_ENTITY signaling|nmod|receptor dissection|acl|signaling dissection|nmod|END_ENTITY	Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor .
23260665	0	p75	57,60	neurotrophin	61,73	p75	neurotrophin	7133	627	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor .
26109945	0	p75	4,7	neurotrophin	8,20	p75	neurotrophin	11168	627	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	The p75 neurotrophin receptor : at the crossroad of neural repair and death .
7943171	0	p75	45,48	neurotrophin	22,34	p75	neurotrophin	7133	627	Gene	Gene	receptors|dobj|START_ENTITY receptors|nsubj|Identification Identification|nmod|END_ENTITY	Identification of the neurotrophin receptors p75 and trk in a series of Wilms ' _ tumors .
11211234	0	p75	52,55	p38beta2	59,67	p75	p38beta2	3560	5600	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities .
1581584	0	p75	49,52	p55	27,30	p75	p55	3560	3559	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Phorbol_esters up-regulate p55 and down-regulate p75 expression of interleukin-2 receptors in human T cells .
2469650	0	p75	87,90	p55	160,163	p75	p55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY sites|nmod|complex formation|nmod|sites Studies|nmod|formation Studies|dep|importance importance|nmod|determinant determinant|nmod|subunit subunit|amod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
2469650	0	p75	87,90	p55	81,84	p75	p55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	complex|amod|START_ENTITY complex|amod|IL-2_receptor IL-2_receptor|dep|+ +|nummod|END_ENTITY	Studies on the formation of high-affinity IL-2 binding sites of an IL-2_receptor p55 + p75 heterodimeric complex : functional importance of a determinant on the p55 subunit defined by a monoclonal antibody AHT-107 .
7836916	0	p75	130,133	p55	42,45	p75	p55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY novel|nmod|role identification|nmod|novel antibodies|dep|identification antibodies|dep|receptors receptors|amod|specific specific|nmod|END_ENTITY	Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors : identification of a novel in vivo role for p75 .
9531303	0	p75	75,78	p55	37,40	p75	p55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	TNF_receptor_type_2|appos|START_ENTITY role|nmod|TNF_receptor_type_2 role|appos|END_ENTITY	Crucial role of TNF_receptor_type_1 -LRB- p55 -RRB- , but not of TNF_receptor_type_2 -LRB- p75 -RRB- , in murine toxoplasmosis .
9712914	0	p75	82,85	p55	65,68	p75	p55	21938(Tax:10090)	21937(Tax:10090)	Gene	Gene	CD120a|appos|START_ENTITY CD120a|appos|END_ENTITY	Cooperative signaling by tumor necrosis factor receptors CD120a -LRB- p55 -RRB- and CD120b -LRB- p75 -RRB- in the expression of nitric_oxide and inducible nitric_oxide synthase by mouse macrophages .
18566344	0	p75	13,16	p75NTR	27,33	p75	p75NTR	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Neurotrophin p75 receptor -LRB- p75NTR -RRB- promotes endothelial cell apoptosis and inhibits angiogenesis : implications for diabetes-induced impaired_neovascularization in ischemic limb muscles .
12858186	0	p75	98,101	tumor_necrosis_factor	102,123	p75	tumor necrosis factor	21938(Tax:10090)	21926(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Electro-gene therapy of collagen-induced_arthritis by using an expression plasmid for the soluble p75 tumor_necrosis_factor receptor-Fc fusion protein .
7504889	0	p75	111,114	tumor_necrosis_factor	157,178	p75	tumor necrosis factor	7133	7124	Gene	Gene	receptor|amod|START_ENTITY contributes|nsubj|receptor contributes|xcomp|activation activation|nmod|concentration concentration|compound|END_ENTITY	Tumor_necrosis_factor activates human endothelial cells through the p55 tumor_necrosis_factor receptor but the p75 receptor contributes to activation at low tumor_necrosis_factor concentration .
7559483	0	p75	35,38	tumor_necrosis_factor	39,60	p75	tumor necrosis factor	7133	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Casein_kinase-1 phosphorylates the p75 tumor_necrosis_factor receptor and negatively regulates tumor_necrosis_factor signaling for apoptosis .
9219699	0	p75	91,94	tumor_necrosis_factor	59,80	p75	tumor necrosis factor	7133	7124	Gene	Gene	receptor|appos|START_ENTITY receptor|compound|END_ENTITY	Treatment of rheumatoid_arthritis with a recombinant human tumor_necrosis_factor receptor -LRB- p75 -RRB- - Fc fusion protein .
15642275	0	p75	92,95	tumor_necrosis_factor-alpha	17,44	p75	tumor necrosis factor-alpha	7133	7124	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Serum neopterin , tumor_necrosis_factor-alpha and soluble tumor necrosis factor receptor II -LRB- p75 -RRB- levels and disease activity in Egyptian female patients with systemic_lupus_erythematosus .
10637439	0	p75NTR	36,42	BDNF	71,75	p75NTR	BDNF	4804	627	Gene	Gene	mediated|nmod|START_ENTITY mediated|nmod|END_ENTITY	Neurotrophin_dependence mediated by p75NTR : contrast between rescue by BDNF and NGF .
16843677	0	p75NTR	72,78	BDNF	58,62	p75NTR	BDNF	4804	627	Gene	Gene	bound|nmod|START_ENTITY bound|nsubj|transport transport|nmod|END_ENTITY	The localization , trafficking and retrograde transport of BDNF bound to p75NTR in sympathetic neurons .
22548193	0	p75NTR	19,25	BDNF	47,51	p75NTR	BDNF	4804	627	Gene	Gene	receptors|amod|START_ENTITY roles|nmod|receptors roles|nmod|effects effects|nmod:poss|END_ENTITY	Divergent roles of p75NTR and Trk receptors in BDNF 's effects on dendritic spine density and morphology .
19570027	0	p75NTR	48,54	IL-1b	23,28	p75NTR	IL-1b	4804	3553	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Inflammatory cytokines IL-1b and TNF-a regulate p75NTR expression in CNS neurons and astrocytes by distinct cell-type-specific signalling mechanisms .
10764727	0	p75NTR	127,133	NADE	0,4	p75NTR	NADE	4804	27018	Gene	Gene	mediated|nmod|START_ENTITY transduction|acl|mediated involved|nmod|transduction involved|nsubjpass|END_ENTITY	NADE , a p75NTR-associated_cell_death_executor , is involved in signal transduction mediated by the common neurotrophin receptor p75NTR .
11224788	0	p75NTR	14,20	NADE	48,52	p75NTR	NADE	24596(Tax:10116)	117089(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of p75NTR and its associated protein NADE in the rat cochlea .
15707575	0	p75NTR	4,10	NF_kappa_B	73,83	p75NTR	NF kappa B	4804	4790	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|pathways pathways|compound|END_ENTITY	The p75NTR mediates a bifurcated signal transduction cascade through the NF_kappa_B and JNK pathways to inhibit cell survival .
19114034	0	p75NTR	19,25	PTEN	0,4	p75NTR	PTEN	4804	5728	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1 .
17082460	0	p75NTR	51,57	Par-3	21,26	p75NTR	Par-3	4804	2151	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The polarity protein Par-3 directly interacts with p75NTR to regulate myelination .
17696763	0	p75NTR	118,124	acid-sensing_ion_channel_3	14,40	p75NTR	acid-sensing ion channel 3	24596(Tax:10116)	286920(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of acid-sensing_ion_channel_3 -LRB- ASIC3 -RRB- in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling .
15953345	0	p75NTR	102,108	myelin-associated_glycoprotein	19,49	p75NTR	myelin-associated glycoprotein	18053(Tax:10090)	17136(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|Binding Binding|nmod|END_ENTITY	Binding of soluble myelin-associated_glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction .
9618141	0	p75NTR	65,71	nerve_growth_factor	14,33	p75NTR	nerve growth factor	18053(Tax:10090)	18049(Tax:10090)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of nerve_growth_factor and its low-affinity receptor -LRB- p75NTR -RRB- during myogenic differentiation .
17910636	0	p75NTR	35,41	nerve_growth_factor_receptor	5,33	p75NTR	nerve growth factor receptor	4804	4804	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	High nerve_growth_factor_receptor -LRB- p75NTR -RRB- expression is a favourable prognostic factor in paediatric B cell precursor-acute_lymphoblastic_leukaemia .
18566344	0	p75NTR	27,33	p75	13,16	p75NTR	p75	18053(Tax:10090)	18053(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Neurotrophin p75 receptor -LRB- p75NTR -RRB- promotes endothelial cell apoptosis and inhibits angiogenesis : implications for diabetes-induced impaired_neovascularization in ischemic limb muscles .
12821676	0	p75NTR	52,58	p75_neurotrophin_receptor	25,50	p75NTR	p75 neurotrophin receptor	4804	4804	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Osmotic swelling induces p75_neurotrophin_receptor -LRB- p75NTR -RRB- expression via nitric_oxide .
18081157	0	p75NTR	80,86	p75_neurotrophin_receptor	53,78	p75NTR	p75 neurotrophin receptor	4804	4804	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Evidence for association between genetic variants of p75_neurotrophin_receptor -LRB- p75NTR -RRB- gene and antidepressant treatment response in Chinese major_depressive_disorder .
18639597	0	p75NTR	96,102	p75_neurotrophin_receptor	69,94	p75NTR	p75 neurotrophin receptor	24596(Tax:10116)	24596(Tax:10116)	Gene	Gene	up-regulation|appos|START_ENTITY up-regulation|nmod|END_ENTITY	Identification and kainic_acid-induced up-regulation of low-affinity p75_neurotrophin_receptor -LRB- p75NTR -RRB- in the nigral dopamine neurons of adult rats .
9763613	0	p75TNF-R	59,67	p75_tumor_necrosis_factor_receptor	23,57	p75TNF-R	p75 tumor necrosis factor receptor	7133	7133	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	A critical role of the p75_tumor_necrosis_factor_receptor -LRB- p75TNF-R -RRB- in organ inflammation independent of TNF , _ lymphotoxin_alpha , or the p55TNF-R .
24333329	0	p75_NTR	64,71	TrkA	72,76	p75 NTR	TrkA	4804	4914	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	Type I interferons up-regulate the expression and signalling of p75_NTR / TrkA receptor complex in differentiated human SH-SY5Y neuroblastoma cells .
16273297	0	p75_TNF_receptor	22,38	TNFR2	40,45	p75 TNF receptor	TNFR2	7133	7133	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lovastatin stimulates p75_TNF_receptor -LRB- TNFR2 -RRB- expression in primary human endothelial cells .
12672017	0	p75_neurotrophin_receptor	0,25	NF-kappa_B	62,72	p75 neurotrophin receptor	NF-kappa B	18053(Tax:10090)	18033(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	p75_neurotrophin_receptor mediates neurotrophin activation of NF-kappa_B and induction of iNOS expression in P19 neurons .
10985348	0	p75_neurotrophin_receptor	48,73	NRAGE	0,5	p75 neurotrophin receptor	NRAGE	4804	9500	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	NRAGE , a novel MAGE protein , interacts with the p75_neurotrophin_receptor and facilitates nerve growth factor-dependent apoptosis .
12169297	0	p75_neurotrophin_receptor	35,60	Neurotrophin	0,12	p75 neurotrophin receptor	Neurotrophin	4804	627	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Neurotrophin signaling through the p75_neurotrophin_receptor .
15857712	0	p75_neurotrophin_receptor	23,48	c-jun	89,94	p75 neurotrophin receptor	c-jun	18053(Tax:10090)	16476(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	Differential effect of p75_neurotrophin_receptor on expression of pro-apoptotic proteins c-jun , p38 and caspase-3 in dorsal root ganglion cells after axotomy in experimental diabetes .
23785138	0	p75_neurotrophin_receptor	0,25	clock	31,36	p75 neurotrophin receptor	clock	18053(Tax:10090)	12753(Tax:10090)	Gene	Gene	gene|nsubj|START_ENTITY gene|compound|END_ENTITY	p75_neurotrophin_receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks .
12821676	0	p75_neurotrophin_receptor	25,50	p75NTR	52,58	p75 neurotrophin receptor	p75NTR	4804	4804	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Osmotic swelling induces p75_neurotrophin_receptor -LRB- p75NTR -RRB- expression via nitric_oxide .
18081157	0	p75_neurotrophin_receptor	53,78	p75NTR	80,86	p75 neurotrophin receptor	p75NTR	4804	4804	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence for association between genetic variants of p75_neurotrophin_receptor -LRB- p75NTR -RRB- gene and antidepressant treatment response in Chinese major_depressive_disorder .
18639597	0	p75_neurotrophin_receptor	69,94	p75NTR	96,102	p75 neurotrophin receptor	p75NTR	24596(Tax:10116)	24596(Tax:10116)	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Identification and kainic_acid-induced up-regulation of low-affinity p75_neurotrophin_receptor -LRB- p75NTR -RRB- in the nigral dopamine neurons of adult rats .
9763613	0	p75_tumor_necrosis_factor_receptor	23,57	p75TNF-R	59,67	p75 tumor necrosis factor receptor	p75TNF-R	7133	7133	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A critical role of the p75_tumor_necrosis_factor_receptor -LRB- p75TNF-R -RRB- in organ inflammation independent of TNF , _ lymphotoxin_alpha , or the p55TNF-R .
20697359	0	p76	38,41	MDM4	14,18	p76	MDM4	196463	4194	Gene	Gene	function|nmod|START_ENTITY function|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of MDM4 -LRB- MDMX -RRB- function by p76 -LRB- MDM2 -RRB- : a new facet in the control of p53 activity .
10942113	0	p78	72,75	MX1	85,88	p78	MX1	10445	4599	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Structure and polymorphism of the human gene for the interferon-induced p78 protein -LRB- MX1 -RRB- : evidence of association with alopecia areata in the Down syndrome region .
15493262	0	p80	95,98	CD4	76,79	p80	CD4	8161	920	Gene	Gene	CDw29|dep|START_ENTITY CDw29|compound|END_ENTITY	Maximal interferon-gamma production and early synthesis of interleukin-2 by CD4 + CDw29 - CD45R - p80 - human T lymphocytes .
10806077	0	p80	45,48	Coil	62,66	p80	Coil	12812(Tax:10090)	12812(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and characterization of the murine p80 coilin gene , Coil .
2142008	0	p80	60,63	IL-1	44,48	p80	IL-1	12812(Tax:10090)	111343(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	In vivo modulation with anti-interleukin-1 -LRB- IL-1 -RRB- receptor -LRB- p80 -RRB- antibody 35F5 of the response to IL-1 .
2142008	0	p80	60,63	IL-1	98,102	p80	IL-1	12812(Tax:10090)	111343(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY modulation|nmod|receptor modulation|dep|antibody antibody|nmod|response response|nmod|END_ENTITY	In vivo modulation with anti-interleukin-1 -LRB- IL-1 -RRB- receptor -LRB- p80 -RRB- antibody 35F5 of the response to IL-1 .
8805640	0	p80	94,97	TNF	98,101	p80	TNF	8161	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors .
9036990	0	p80	70,73	TNF	15,18	p80	TNF	8161	7124	Gene	Gene	cytotoxicity|nmod|START_ENTITY cytotoxicity|compound|END_ENTITY	Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80 : requirement of the TNF_receptor-associated_factor-2 binding site .
9531270	0	p80	22,25	TNF	26,29	p80	TNF	8161	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis , nuclear_factor-kappa_B activation , and c-Jun kinase activation .
8176381	0	p80	42,45	bovine_viral_diarrhoea_virus	13,41	p80	bovine viral diarrhoea virus	505638(Tax:9913)	105754165	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Detection of bovine_viral_diarrhoea_virus p80 protein in subpopulations of bovine leukocytes .
10806077	0	p80	45,48	coilin	49,55	p80	coilin	12812(Tax:10090)	12812(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Structure and characterization of the murine p80 coilin gene , Coil .
11522867	0	p80	28,31	erythropoietin	84,98	p80	erythropoietin	8161	2056	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	High blood soluble receptor p80 for tumour necrosis factor-alpha is associated with erythropoietin resistance in haemodialysis patients .
12757932	0	p80_coilin	0,10	ataxin-1	59,67	p80 coilin	ataxin-1	8161	6310	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	p80_coilin , a coiled body-specific protein , interacts with ataxin-1 , the SCA1 gene product .
20538862	0	p84	46,49	UL44	55,59	p84	UL44	9984	3077460(Tax:10359)	Gene	Gene	START_ENTITY|nmod|DNA DNA|compound|END_ENTITY	Role of the specific interaction of UL112-113 p84 with UL44 DNA polymerase processivity factor in promoting DNA replication of human_cytomegalovirus .
9852111	0	p85	4,7	Fc_receptor_gamma-chain	69,92	p85	Fc receptor gamma-chain	5296	2207	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc_receptor_gamma-chain and linker for activitor of T cells -LRB- LAT -RRB- in platelets stimulated by collagen and convulxin .
18420583	0	p85	115,118	Insulin-like_growth_factor-I	0,28	p85	Insulin-like growth factor-I	5296	3479	Gene	Gene	activation|nmod|START_ENTITY stimulates|dobj|activation stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor-I stimulates Shc-dependent phosphatidylinositol_3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells .
24550137	0	p85	21,24	MiR-503	0,7	p85	MiR-503	5296	574506	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MiR-503 targets PI3K p85 and IKK-b and suppresses progression of non-small cell lung_cancer .
17043656	0	p85	4,7	PI3K	30,34	p85	PI3K	5295	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals .
17170431	0	p85	124,127	PI3K	139,143	p85	PI3K	5296	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
24651434	0	p85	54,57	PI3K	80,84	p42	PI3K	23552	5293	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP .
25114970	0	p85	4,7	PI3K	30,34	p85	PI3K	5295	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	The p85 regulatory subunit of PI3K mediates cAMP-PKA and insulin biological effects on MCF-7 cell growth and motility .
19635806	0	p85	0,3	PTEN	37,41	p85	PTEN	5296	5728	Gene	Gene	Associates|amod|START_ENTITY Associates|nmod|END_ENTITY	p85 Associates with unphosphorylated PTEN and the PTEN-associated complex .
11679587	0	p85	30,33	Phosphatidylinositol_3-kinase	0,29	p85	Phosphatidylinositol 3-kinase	5296	5293	Gene	Gene	adaptor|amod|START_ENTITY adaptor|amod|END_ENTITY	Phosphatidylinositol_3-kinase p85 adaptor function in T-cells .
17170431	0	p85	124,127	phosphatidylinositol_3-kinase	44,73	p85	phosphatidylinositol 3-kinase	5296	5295	Gene	Gene	subunit|amod|START_ENTITY activates|nmod|subunit activates|dobj|pathway pathway|amod|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
18420583	0	p85	115,118	phosphatidylinositol_3-kinase	54,83	p85	phosphatidylinositol 3-kinase	5296	5295	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Insulin-like_growth_factor-I stimulates Shc-dependent phosphatidylinositol_3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells .
20212113	0	p85	42,45	phosphatidylinositol_3-kinase	57,86	p85	phosphatidylinositol 3-kinase	13601(Tax:10090)	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol_3-kinase .
22158866	0	p85	100,103	phosphatidylinositol_3-kinase	115,144	p85	phosphatidylinositol 3-kinase	5296	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- .
15388330	0	p85	104,107	phosphoinositide_3-kinase	119,144	p85	phosphoinositide 3-kinase	5296	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Association of the Src_homology_2_domain-containing_leukocyte_phosphoprotein_of_76_kD -LRB- SLP-76 -RRB- with the p85 subunit of phosphoinositide_3-kinase .
16006513	0	p85	83,86	phosphoinositide_3-kinase	110,135	p85	phosphoinositide 3-kinase	13601(Tax:10090)	18708(Tax:10090)	Gene	Gene	subunits|amod|START_ENTITY subunits|nmod|END_ENTITY	Modulation of epithelial_neoplasia and lymphoid_hyperplasia in PTEN + / - mice by the p85 regulatory subunits of phosphoinositide_3-kinase .
16473619	0	p85_alpha	48,57	phosphatidylinositol_3-kinase	69,98	p85 alpha	phosphatidylinositol 3-kinase	5295	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Assay and stimulation of the Rab5 GTPase by the p85_alpha subunit of phosphatidylinositol_3-kinase .
21057544	0	p85a	0,4	p300	38,42	p85a	p300	5295	2033	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	p85a mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response .
21077741	0	p85a	38,42	phosphatidylinositol_3-kinase	62,91	p85a	phosphatidylinositol 3-kinase	5295	5291	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Posttranscriptional regulation of the p85a adapter subunit of phosphatidylinositol_3-kinase in human leukemia cells .
19304514	0	p85alpha	6,14	PI3K	1,5	p85alpha	PI3K	5295	5295	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	-LSB- PI3K p85alpha expression and its role in the progression of colorectal_cancer -RSB- .
20007249	0	p85alpha	112,120	PI3K	143,147	p85alpha	PI3K	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Reduced T cell expansion by a superantigen as a result of impaired B cell development in mice deficient for the p85alpha regulatory subunit of PI3K .
16873706	0	p85alpha	127,135	insulin_receptor_substrate-1	70,98	p85alpha	insulin receptor substrate-1	5295	3667	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|expression expression|amod|END_ENTITY	Molecular mechanisms of insulin resistance : serine phosphorylation of insulin_receptor_substrate-1 and increased expression of p85alpha : the two sides of a coin .
9032108	0	p85alpha	58,66	phosphatidylinositol_3-kinase	89,118	p85alpha	phosphatidylinositol 3-kinase	5295	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Identification of a common amino_acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol_3-kinase : effects on glucose_disappearance constant , glucose effectiveness , and the insulin sensitivity index .
18538520	0	p85alpha	80,88	phosphoinositide-3_kinase	100,125	p85alpha	phosphoinositide-3 kinase	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Hyperactivity , memory_deficit and anxiety-related_behaviors in mice lacking the p85alpha subunit of phosphoinositide-3_kinase .
10525402	0	p85alpha	54,62	phosphoinositide_3-kinase	85,110	p85alpha	phosphoinositide 3-kinase	5295	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide_3-kinase : an SH2 domain mimicking its own substrate .
11555646	0	p85alpha	64,72	phosphoinositide_3-kinase	84,109	p85alpha	phosphoinositide 3-kinase	5295	5295	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide_3-kinase to phosphatidylinositol_3 ,4,5 - trisphosphate .
25385636	0	p85b	45,49	phosphatidylinositol_3-kinase	53,82	p85b	phosphatidylinositol 3-kinase	5296	5291	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Oncogenic activity of the regulatory subunit p85b of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- .
11752399	0	p85beta	46,53	phosphoinositide_3-kinase	65,90	p85beta	phosphoinositide 3-kinase	18709(Tax:10090)	18708(Tax:10090)	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	Increased_insulin_sensitivity in mice lacking p85beta subunit of phosphoinositide_3-kinase .
11231148	0	p90	40,43	Bub1	0,4	p90	Bub1	399376(Tax:8355)	398234(Tax:8355)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Bub1 is activated by the protein kinase p90 -LRB- Rsk -RRB- during Xenopus oocyte maturation .
19565011	0	p90	32,35	MDM2	27,31	p90	MDM2	57650	4193	Gene	Gene	protein|amod|START_ENTITY protein|nummod|END_ENTITY	Progesterone inhibition of MDM2 p90 protein in MCF-7 human breast_cancer cell line is dependent on p53 levels .
23970478	0	p90	4,7	RSK	8,11	p90	RSK	57650	6196	Gene	Gene	members|amod|START_ENTITY members|compound|END_ENTITY	The p90 RSK family members : common functions and isoform specificity .
10762642	0	p90	46,49	erbB-2	31,37	p90	erbB-2	57650	2064	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Tyrosine phosphorylation of an erbB-2 related p90 protein induced by estrogen in human breast epithelial cells .
15840586	0	p90RSK	33,39	cardiac_troponin_I	114,132	p90RSK	cardiac troponin I	20112(Tax:10090)	21954(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of p90_ribosomal_S6_kinase -LRB- p90RSK -RRB- in reactive oxygen species and protein_kinase_C_beta -LRB- PKC-beta -RRB- - mediated cardiac_troponin_I phosphorylation .
9218456	0	p90Rsk	47,53	Syk	0,3	p90Rsk	Syk	386579(Tax:9031)	427272(Tax:9031)	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Syk is required for BCR-mediated activation of p90Rsk , but not p70S6k , via a mitogen-activated protein kinase-independent pathway in B cells .
25578862	0	p90Rsk	48,54	p90_Ribosomal_S6_Kinase	23,46	p90Rsk	p90 Ribosomal S6 Kinase	6195	6195	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	RhoA Kinase -LRB- Rock -RRB- and p90_Ribosomal_S6_Kinase -LRB- p90Rsk -RRB- phosphorylation of the sodium_hydrogen exchanger -LRB- NHE1 -RRB- is required for lysophosphatidic_acid-induced transport , cytoskeletal organization and migration .
25578862	0	p90_Ribosomal_S6_Kinase	23,46	p90Rsk	48,54	p90 Ribosomal S6 Kinase	p90Rsk	6195	6195	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	RhoA Kinase -LRB- Rock -RRB- and p90_Ribosomal_S6_Kinase -LRB- p90Rsk -RRB- phosphorylation of the sodium_hydrogen exchanger -LRB- NHE1 -RRB- is required for lysophosphatidic_acid-induced transport , cytoskeletal organization and migration .
11260258	0	p90rsk1	26,33	Tob	80,83	p90rsk1	Tob	20111(Tax:10090)	22057(Tax:10090)	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob .
15956473	0	p94	10,13	Calpain_3	0,9	p94	Calpain 3	12335(Tax:10090)	12335(Tax:10090)	Gene	Gene	involved|nsubjpass|START_ENTITY END_ENTITY|parataxis|involved	Calpain_3 / p94 is not involved in postmortem proteolysis .
16533054	0	p94	30,33	calpain_3	19,28	p94	calpain 3	825	825	Gene	Gene	activation|appos|START_ENTITY activation|amod|END_ENTITY	Ca2 + dependency of calpain_3 -LRB- p94 -RRB- activation .
21556036	0	p97	4,7	EEA1	31,35	p97	EEA1	4241	8411	Gene	Gene	associates|amod|START_ENTITY associates|nmod|END_ENTITY	The p97 ATPase associates with EEA1 to regulate the size of early endosomes .
4045562	0	p97	63,66	Fab	51,54	p97	Fab	4241	2187	Gene	Gene	localization|nmod|START_ENTITY localization|nmod|END_ENTITY	Melanoma localization in nude_mice with monoclonal Fab against p97 .
9261175	0	p97	82,85	T-cell_protein_tyrosine_phosphatase	19,54	p97	T-cell protein tyrosine phosphatase	4241	5771	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the T-cell_protein_tyrosine_phosphatase with nuclear import factor p97 .
19174149	0	p97	12,15	UBXD1	0,5	p97	UBXD1	4241	80700	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	UBXD1 binds p97 through two independent binding sites .
26475856	0	p97	143,146	UBXD1	62,67	p97	UBXD1	4241	80700	Gene	Gene	Communication|nmod|START_ENTITY Modulates|dobj|Communication Modulates|nsubj|Region Region|nmod|UBX_Domain-containing_Protein_1 UBX_Domain-containing_Protein_1|appos|END_ENTITY	The N-terminal Region of the UBX_Domain-containing_Protein_1 -LRB- UBXD1 -RRB- Modulates Interdomain Communication within the Valosin-containing Protein p97 .
18656546	0	p97	40,43	Ubxd1	0,5	p97	Ubxd1	7415	80700	Gene	Gene	ATPase|amod|START_ENTITY co-factor|nmod|ATPase co-factor|nsubj|END_ENTITY	Ubxd1 is a novel co-factor of the human p97 ATPase .
27086594	0	p97	52,55	VCP	57,60	p97	VCP	7415	7415	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Strategic role of the ubiquitin-dependent segregase p97 -LRB- VCP or Cdc48 -RRB- in DNA replication .
26504085	0	p97	53,56	selenoprotein_K	26,41	p97	selenoprotein K	7415	58515	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Selenoprotein_S-dependent selenoprotein_K binding to p97 -LRB- VCP -RRB- is essential for endoplasmic reticulum-associated degradation .
14761919	0	p97	52,55	valosin-containing_protein	24,50	p97	valosin-containing protein	7415	7415	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of valosin-containing_protein -LRB- p97 -RRB- is associated with lymph node metastasis and prognosis of pancreatic_ductal_adenocarcinoma .
15131036	0	p97	51,54	valosin-containing_protein	23,49	p97	valosin-containing protein	7415	7415	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Elevated expression of valosin-containing_protein -LRB- p97 -RRB- is associated with poor prognosis of prostate_cancer .
16189643	0	p97	52,55	valosin-containing_protein	24,50	p97	valosin-containing protein	7415	7415	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Increased expression of valosin-containing_protein -LRB- p97 -RRB- is correlated with disease recurrence in follicular_thyroid_cancer .
17584300	0	p97	48,51	valosin-containing_protein	15,41	p97	valosin-containing protein	7415	7415	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of valosin-containing_protein -LRB- VCP -RRB- / p97 in the formation and clearance of abnormal protein aggregates .
7969157	0	p97MAPK	32,39	ERK-3	70,75	p97MAPK	ERK-3	5597	58840(Tax:10116)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	Cloning and characterization of p97MAPK , a novel human homolog of rat ERK-3 .
10738249	0	p9Ka	49,53	S100A4	41,47	p9Ka	S100A4	6275	6275	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Localisation by in situ hybridisation of S100A4 -LRB- p9Ka -RRB- mRNA in primary human breast_tumour specimens .
10749128	0	p9Ka	67,71	S100A4	59,65	p9Ka	S100A4	6275	6275	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Prognostic significance of the metastasis-inducing protein S100A4 -LRB- p9Ka -RRB- in human breast_cancer .
11875708	0	p9Ka	8,12	S100A4	0,6	p9Ka	S100A4	6275	6275	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	S100A4 -LRB- p9Ka -RRB- protein in colon_carcinoma and liver metastases : association with carcinoma cells and T-lymphocytes .
9242709	0	p9Ka	67,71	S100A4	59,65	p9Ka	S100A4	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	down-regulation|appos|START_ENTITY down-regulation|nmod|END_ENTITY	Transcriptional down-regulation of the metastasis-inducing S100A4 -LRB- p9Ka -RRB- in benign but not in malignant rat mammary epithelial cells by GC-factor .
9891019	0	p9Ka	127,131	S100A4	119,125	p9Ka	S100A4	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Differential reactivity of the rat S100A4 -LRB- p9Ka -RRB- gene to sodium_bisulfite is associated with differential levels of the S100A4 -LRB- p9Ka -RRB- mRNA in rat mammary epithelial cells .
9891019	0	p9Ka	42,46	S100A4	35,41	p9Ka	S100A4	24615(Tax:10116)	24615(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Differential reactivity of the rat S100A4 -LRB- p9Ka -RRB- gene to sodium_bisulfite is associated with differential levels of the S100A4 -LRB- p9Ka -RRB- mRNA in rat mammary epithelial cells .
7928629	0	pEL98	52,57	mts1	62,66	pEL98	mts1	20198(Tax:10090)	20198(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of S100-related calcium-binding protein pEL98 -LRB- or mts1 -RRB- in cell motility and tumor cell invasion .
21978279	0	pERK	14,18	YKL40	83,88	pERK	YKL40	9451	1116	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|correlation correlation|nmod|END_ENTITY	Expression of pERK and pAKT in pediatric high grade astrocytomas : correlation with YKL40 and prognostic significance .
19520849	0	pICLn	8,13	PRMT5	47,52	pICLn	PRMT5	1207	10419	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of pICLn in methylation of Sm proteins by PRMT5 .
21081503	0	pICln	87,92	PRMT5	119,124	pICln	PRMT5	1207	10419	Gene	Gene	START_ENTITY|nmod|composition composition|amod|END_ENTITY	RioK1 , a new interactor of protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- , competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity .
21081503	0	pICln	87,92	PRMT5	65,70	pICln	PRMT5	1207	10419	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|RioK1 RioK1|appos|interactor interactor|nmod|protein_arginine_methyltransferase_5 protein_arginine_methyltransferase_5|appos|END_ENTITY	RioK1 , a new interactor of protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- , competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity .
21081503	0	pICln	87,92	RioK1	0,5	pICln	RioK1	1207	83732	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	RioK1 , a new interactor of protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- , competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity .
15103747	0	pIgR	120,124	FcRn	75,79	pIgR	FcRn	100144764(Tax:9940)	100144766(Tax:9940)	Gene	Gene	receptor|appos|START_ENTITY receptor|appos|END_ENTITY	Effects of mycophenolic_acid -LRB- MPA -RRB- treatment on expression of Fc receptor -LRB- FcRn -RRB- and polymeric immunoglobulin receptor -LRB- pIgR -RRB- mRNA in adult sheep tissues .
26910773	0	pIgR	57,61	polymeric_immunoglobulin_receptor	22,55	pIgR	polymeric immunoglobulin receptor	5284	5284	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Reduced expression of polymeric_immunoglobulin_receptor -LRB- pIgR -RRB- in nasopharyngeal_carcinoma and its correlation with prognosis .
11570573	0	pRB	54,57	Cyclin	0,6	pRB	Cyclin	5925	5111	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Cyclin D1 expression and retinoblastoma gene protein -LRB- pRB -RRB- expression in esophageal_squamous_cell_carcinoma .
19433082	0	pRB	21,24	E2F4	0,4	pRB	E2F4	19645(Tax:10090)	104394(Tax:10090)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	E2F4 cooperates with pRB in the development of extra-embryonic tissues .
16510145	0	pRB	51,54	MdmX	11,15	pRB	MdmX	5925	4194	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of MdmX on Mdm2-mediated downregulation of pRB .
23634261	0	pRB	40,43	PP2A	0,4	pRB	PP2A	5925	5524	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|compound|END_ENTITY	PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs : Potential Implications for PP2A Disruption in Cancer .
23634261	0	pRB	40,43	PP2A	110,114	pRB	PP2A	5925	5524	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|dep|Implications Implications|nmod|Disruption Disruption|compound|END_ENTITY	PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs : Potential Implications for PP2A Disruption in Cancer .
25483052	0	pRB	43,46	PP2A	0,4	pRB	PP2A	5925	5524	Gene	Gene	proteins|compound|START_ENTITY switch|nmod|proteins END_ENTITY|dep|switch	PP2A : more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues .
11226218	0	pRB	0,3	Sp1	12,15	pRB	Sp1	5925	6667	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activity activity|amod|END_ENTITY	pRB induces Sp1 activity by relieving inhibition mediated by MDM2 .
12594215	0	pRB	71,74	cyclin_D1	34,43	pRB	cyclin D1	5925	595	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	NF-kappa_B-dependent induction of cyclin_D1 by retinoblastoma protein -LRB- pRB -RRB- family proteins and tumor-derived pRB mutants .
15845746	0	pRB	101,104	cyclin_D1	89,98	pRB	cyclin D1	5925	595	Gene	Gene	pathway|advmod|START_ENTITY >|amod|pathway >|dep|GSK-3beta GSK-3beta|dep|END_ENTITY	Progesterone inhibits the estrogen-induced phosphoinositide 3-kinase -- > AKT -- > GSK-3beta -- > cyclin_D1 -- > pRB pathway to block uterine epithelial cell proliferation .
10573135	0	pRB	23,26	cyclin_D3	45,54	pRB	cyclin D3	5925	896	Gene	Gene	Hypophosphorylation|nmod|START_ENTITY Hypophosphorylation|nmod|END_ENTITY	Hypophosphorylation of pRB and repression of cyclin_D3 and cdc25A during the granulocytic differentiation of human myeloblastic_leukemia ML-1 cells .
10573136	0	pRB	23,26	cyclin_D3	45,54	pRB	cyclin D3	5925	896	Gene	Gene	Hypophosphorylation|nmod|START_ENTITY Hypophosphorylation|nmod|END_ENTITY	Hypophosphorylation of pRB and repression of cyclin_D3 and cdc25A during the granulocytic differentiation of human myeloblastic_leukemia ML-1 cells .
10906146	0	pRB	94,97	p130	78,82	pRB	p130	5925	5934	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Cdk2-dependent phosphorylation and functional inactivation of the pRB-related p130 protein in pRB -LRB- - -RRB- , p16INK4A -LRB- + -RRB- tumor cells .
10547597	0	pRB	30,33	p16	14,17	pRB	p16	5925	1029	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of p16 and lack of pRB in primary small_cell_lung_cancer .
12016143	0	pRB	104,107	p16	93,96	pRB	p16	5925	1029	Gene	Gene	stimulates|dep|START_ENTITY stimulates|acl:relcl|serum serum|nmod|inactivation inactivation|nmod|END_ENTITY	Id-1 stimulates serum independent prostate_cancer cell proliferation through inactivation of p16 -LRB- INK4a -RRB- / pRB pathway .
12416540	0	pRB	106,109	p16	47,50	pRB	p16	5925	1029	Gene	Gene	expression|compound|START_ENTITY loss|nmod|expression results|nmod|loss results|nsubj|expression expression|nmod|END_ENTITY	Conditional expression of the tumor suppressor p16 in a heterotopic_glioblastoma model results in loss of pRB expression .
25291363	0	pRB	79,82	p16	119,122	pRB	p16	5925	1029	Gene	Gene	Phosphorylation|compound|START_ENTITY Phosphorylation|nmod|END_ENTITY	Polyomavirus-Associated Trichodysplasia Spinulosa Involves Hyperproliferation , pRB Phosphorylation and Upregulation of p16 and p21 .
11496322	0	pRB	80,83	p21	131,134	pRB	p21	5925	1026	Gene	Gene	phosphorylation|compound|START_ENTITY inhibition|nmod|phosphorylation inhibition|nmod|END_ENTITY	Doenjang hexane fraction-induced G1_arrest is associated with the inhibition of pRB phosphorylation and induction of Cdk inhibitor p21 in human breast_carcinoma MCF-7 cells .
12689523	0	pRB	90,93	p21	141,144	pRB	p21	5925	1026	Gene	Gene	phosphorylation|compound|START_ENTITY down-regulation|nmod|phosphorylation beta-lapachone|nmod|down-regulation END_ENTITY|amod|beta-lapachone	Suppression_of_human_prostate_cancer cell growth by beta-lapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21 -LRB- WAF1/CIP1 -RRB- .
15056456	0	pRb	49,52	COX-2	9,14	pRb	COX-2	5925	5743	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex .
9374720	0	pRb	37,40	Cyclin_D1	0,9	pRb	Cyclin D1	5925	595	Gene	Gene	growth|compound|START_ENTITY destabilizes|dobj|growth destabilizes|nsubj|RNA RNA|compound|END_ENTITY	Cyclin_D1 antisense RNA destabilizes pRb and retards lung_cancer cell growth .
20616879	0	pRb	27,30	E2F-1	0,5	pRb	E2F-1	5925	1869	Gene	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity .
20586193	0	pRb	10,13	E2F4	63,67	pRb	E2F4	5925	1874	Gene	Gene	mutation|compound|START_ENTITY induces|nsubj|mutation induces|nmod|END_ENTITY	-LSB- A pocket pRb mutation induces the increase in its affinity to E2F4 coupled with activation of muscle differentiation -RSB- .
16753023	0	pRb	21,24	HES1	0,4	pRb	HES1	5925	3280	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	HES1 cooperates with pRb to activate RUNX2-dependent transcription .
20948316	0	pRb	118,121	Hec1	38,42	pRb	Hec1	5925	10403	Gene	Gene	pathway|compound|START_ENTITY END_ENTITY|nmod|pathway	Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway .
15257544	0	pRb	122,125	INK4a	18,23	pRb	INK4a	5925	1029	Gene	Gene	status|compound|START_ENTITY END_ENTITY|nmod|status	Profiles of the 2 INK4a gene products , p16 and p14ARF , in human reference urothelium and bladder_carcinomas , according to pRb and p53 protein status .
12868001	0	pRb	121,124	MG132	86,91	pRb	MG132	5925	875581(Tax:243273)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of apoptosis in human osteosarcoma Saos-2 cells by the proteasome inhibitor MG132 and the protective effect of pRb .
12807244	0	pRb	173,176	PCNA	215,219	pRb	PCNA	5925	5111	Gene	Gene	correlation|nmod|START_ENTITY correlation|appos|END_ENTITY	Immunohistochemical expression of heat_shock protein 27 , in normal hyperplastic and neoplastic endometrium : correlation with estrogen and progesterone_receptor status , p53 , pRb and proliferation associated indices -LRB- PCNA , MIB1 -RRB- .
9258347	0	pRb	43,46	PITALRE	20,27	pRb	PITALRE	5925	1025	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	CDC2-related_kinase PITALRE phosphorylates pRb exclusively on serine and is widely expressed in human tissues .
15881662	0	pRb	78,81	RB1	36,39	pRb	RB1	5925	5925	Gene	Gene	gene|nmod|START_ENTITY gene|nummod|END_ENTITY	Altered structure and expression of RB1 gene and increased phosphorylation of pRb in human vestibular_schwannomas .
7555731	0	pRb	0,3	TGF-beta_1	55,65	pRb	TGF-beta 1	19645(Tax:10090)	21803(Tax:10090)	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	pRb is necessary for inhibition of N-myc expression by TGF-beta_1 in embryonic lung organ cultures .
11571651	0	pRb	76,79	UNP	15,18	pRb	UNP	19645(Tax:10090)	22258(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of UNP , a ubiquitin-specific protease , with the pocket proteins pRb , p107 and p130 .
11418138	0	pRb	0,3	c-Jun_N-terminal_kinase	95,118	pRb	c-Jun N-terminal kinase	5925	5599	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|advcl|inhibiting inhibiting|dobj|END_ENTITY	pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun_N-terminal_kinase .
11114723	0	pRb	43,46	catalytic_subunit_of_DNA_polymerase_delta	57,98	pRb	catalytic subunit of DNA polymerase delta	5925	7508	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the retinoblastoma protein -LRB- pRb -RRB- with the catalytic_subunit_of_DNA_polymerase_delta -LRB- p125 -RRB- .
15809880	0	pRb	65,68	cyclin_D1	20,29	pRb	cyclin D1	5925	595	Gene	Gene	status|compound|START_ENTITY value|nmod|status value|nmod|overexpression overexpression|amod|END_ENTITY	Prognostic value of cyclin_D1 overexpression in correlation with pRb and p53 status in non-small_cell_lung_cancer -LRB- NSCLC -RRB- .
17699765	0	pRb	10,13	cyclin_D1	36,45	pRb	cyclin D1	19645(Tax:10090)	12443(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The LxCxE pRb interaction domain of cyclin_D1 is dispensable for murine development .
16303160	0	pRb	91,94	cyclin_D3	81,90	pRb	cyclin D3	5925	896	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	SARS_coronavirus 7a protein blocks cell cycle progression at G0/G1 phase via the cyclin_D3 / pRb pathway .
17699777	0	pRb	52,55	estrogen_receptor-alpha	25,48	pRb	estrogen receptor-alpha	5925	2099	Gene	Gene	proteins|compound|START_ENTITY END_ENTITY|nmod|proteins	Epigenetic modulation of estrogen_receptor-alpha by pRb family proteins : a novel mechanism in breast_cancer .
10226946	0	pRb	68,71	p16	63,66	pRb	p16	5925	1029	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
16616093	0	pRb	21,24	p16	0,3	pRb	p16	5925	1029	Gene	Gene	retinoblastoma|appos|START_ENTITY END_ENTITY|appos|retinoblastoma	p16 , retinoblastoma -LRB- pRb -RRB- , and cyclin_D1 protein expression in human endometriotic and adenomyotic_lesions .
20703084	0	pRb	91,94	p16	31,34	pRb	p16	5925	1029	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|overexpression overexpression|amod|END_ENTITY	S-phase lengthening induced by p16 -LRB- INK4a -RRB- overexpression in malignant cells with wild-type pRb and p53 .
25675863	0	pRb	15,18	p16	4,7	pRb	p16	5925	1029	Gene	Gene	pathway|compound|START_ENTITY define|nsubj|pathway /|ccomp|define /|nsubj|END_ENTITY	The p16 -LRB- INK4A -RRB- / pRb pathway and telomerase activity define a subgroup of Ph + adult Acute_Lymphoblastic_Leukemia associated with inferior outcome .
7834615	0	pRb	36,39	p16	10,13	pRb	p16	5925	1029	Gene	Gene	alterations|compound|START_ENTITY correlate|nmod|alterations correlate|nsubj|levels levels|amod|END_ENTITY	Increased p16 levels correlate with pRb alterations in human urothelial cells .
7954450	0	pRb	129,132	p16	75,78	pRb	p16	5925	1029	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb .
7585516	0	pRb	43,46	p16INK4	8,15	pRb	p16INK4	5925	1029	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Lack of p16INK4 or retinoblastoma protein -LRB- pRb -RRB- , or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial_tumors and cell lines .
19130399	0	pRb	12,15	p16INK4A	17,25	pRb	p16INK4A	5925	1029	Gene	Gene	START_ENTITY|appos|proteins proteins|amod|END_ENTITY	Analysis of pRb , p16INK4A proteins and proliferating antigens : PCNA , Ki-67 and MCM5 expression in aggressive fibromatosis -LRB- desmoid_tumor -RRB- .
11329487	0	pRb	70,73	p21	32,35	pRb	p21	5925	644914	Gene	Gene	hyperphosphorylated|dobj|START_ENTITY hyperphosphorylated|nsubj|expression expression|nmod|END_ENTITY	Ethanol decreases expression of p21 and increases hyperphosphorylated pRb in cell lines of squamous_cell_carcinomas of the head and neck .
12383116	0	pRb	67,70	p21	14,17	pRb	p21	5925	1026	Gene	Gene	phosphorylation|compound|START_ENTITY inhibitors|nmod|phosphorylation derived|dobj|inhibitors END_ENTITY|acl|derived	Highly potent p21 -LRB- WAF1 -RRB- - derived peptide inhibitors of CDK-mediated pRb phosphorylation : delineation and structural insight into their interactions with cyclin_A .
15875733	0	pRb	49,52	p21	44,47	pRb	p21	5925	644914	Gene	Gene	p53|dep|START_ENTITY p53|dep|END_ENTITY	Correlations of cell cycle regulators -LRB- p53 , p21 , pRb and mdm2 -RRB- and c-erbB-2 with biological markers of proliferation and overall survival in breast_cancer .
9418909	0	pRb	80,83	p21	11,14	pRb	p21	5925	1026	Gene	Gene	determinant|nsubj|START_ENTITY transitions|parataxis|determinant transitions|nsubj|Effects Effects|nmod|Cip1/Waf1 Cip1/Waf1|amod|END_ENTITY	Effects of p21 -LRB- Cip1/Waf1 -RRB- at both the G1/S and the G2/M cell cycle transitions : pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication .
10226946	0	pRb	68,71	p27	78,81	pRb	p27	5925	3429	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
24229711	0	pRb	82,85	p27	24,27	pRb	p27	5925	3429	Gene	Gene	suppressors|compound|START_ENTITY absence|nmod|suppressors tumorigenesis|nmod|absence safeguard|ccomp|tumorigenesis safeguard|nsubj|END_ENTITY	Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors .
15868430	0	pRb	168,171	p27Kip1_and_decrease_in_retinoblastoma_protein	120,166	pRb	p27Kip1 and decrease in retinoblastoma protein	5925	5925;1027	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Inositol_hexaphosphate -LRB- IP6 -RRB- blocks proliferation of human breast_cancer cells through a PKCdelta-dependent increase in p27Kip1_and_decrease_in_retinoblastoma_protein -LRB- pRb -RRB- phosphorylation .
10226946	0	pRb	68,71	p53	73,76	pRb	p53	5925	7157	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Immunohistochemical analysis of cell cycle-associated proteins p16 , pRb , p53 , p27 and Ki-67 in oral_cancer and precancer with special reference to verrucous_carcinomas .
10353761	0	pRb	54,57	p53	97,100	pRb	p53	5925	7157	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|nmod|alteration alteration|compound|END_ENTITY	Loss of heterozygosity of the Rb gene correlates with pRb protein expression and associates with p53 alteration in human esophageal_cancer .
10611334	0	pRb	150,153	p53	28,31	pRb	p53	5925	7157	Gene	Gene	function|compound|START_ENTITY compromised|nmod|function cells|acl|compromised defective|nsubj|cells repair|dep|defective compromised|dobj|repair compromised|nmod|exhibit exhibit|compound|END_ENTITY	Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair , whereas cells compromised for pRb function are defective only in global repair .
10899671	0	pRb	20,23	p53	15,18	pRb	p53	5925	7157	Gene	Gene	Alterations|appos|START_ENTITY Alterations|nmod|END_ENTITY	Alterations of p53 , pRb , cyclin_D -LRB- 1 -RRB- and cdk4 in human oral and pharyngeal squamous_cell_carcinomas .
11121443	0	pRb	71,74	p53	0,3	pRb	p53	19645(Tax:10090)	22059(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY triggering|dobj|activity regulates|advcl|triggering regulates|nsubj|END_ENTITY	p53 regulates myogenesis by triggering the differentiation activity of pRb .
9649429	0	pRb	16,19	p53	0,3	pRb	p53	5925	7157	Gene	Gene	cleavage|compound|START_ENTITY cleavage|compound|END_ENTITY	p53 facilitates pRb cleavage in IL-3-deprived cells : novel pro-apoptotic activity of p53 .
9649429	0	pRb	16,19	p53	85,88	pRb	p53	5925	7157	Gene	Gene	cleavage|compound|START_ENTITY cleavage|dep|activity activity|nmod|END_ENTITY	p53 facilitates pRb cleavage in IL-3-deprived cells : novel pro-apoptotic activity of p53 .
16861234	0	pS2	100,103	PRMT1	112,117	pS2	PRMT1	7031	3276	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1 .
11310832	0	pS2	55,58	TFF1	60,64	pS2	TFF1	7031	7031	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Augmented intestinal_trefoil_factor -LRB- TFF3 -RRB- and loss of pS2 -LRB- TFF1 -RRB- expression precedes metaplastic differentiation of gastric epithelium .
17565651	0	pS2	23,26	TFF1	17,21	pS2	TFF1	7031	7031	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Up-regulation of TFF1 -LRB- pS2 -RRB- expression by TNF-alpha in gastric epithelial cells .
19132993	0	pS2	0,3	TFF1	5,9	pS2	TFF1	7031	7031	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	pS2 -LRB- TFF1 -RRB- expression in prostate_carcinoma : correlation with steroid receptor status .
9413220	0	pS2	35,38	cathepsin-D	22,33	pS2	cathepsin-D	338412	1509	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Relationships between cathepsin-D , pS2 protein and hormonal receptors in breast_cancer cytosols : inconsistency with their established prognostic significance .
2303034	0	pS2	38,41	hSP	0,3	pS2	hSP	338412	7190	Gene	Gene	protein|amod|START_ENTITY homolog|nmod|protein END_ENTITY|appos|homolog	hSP , the domain-duplicated homolog of pS2 protein , is co-expressed with pS2 in stomach but not in breast_carcinoma .
2303034	0	pS2	72,75	hSP	0,3	pS2	hSP	338412	7190	Gene	Gene	co-expressed|nmod|START_ENTITY co-expressed|nsubjpass|END_ENTITY	hSP , the domain-duplicated homolog of pS2 protein , is co-expressed with pS2 in stomach but not in breast_carcinoma .
9050913	0	pS2	55,58	hSP	98,101	pS2	hSP	7031	7190	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Close physical linkage of the genes encoding the pNR-2 / pS2 protein and human spasmolytic protein -LRB- hSP -RRB- .
12603742	0	pSAM2_immunity_factor	105,126	pif	95,98	pSAM2 immunity factor	pif	117159	117159	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Conjugal immunity of Streptomyces strains carrying the integrative element pSAM2 is due to the pif gene -LRB- pSAM2_immunity_factor -RRB- .
8012775	0	pT1	48,51	p53	33,36	pT1	p53	58492	7157	Gene	Gene	cell|amod|START_ENTITY END_ENTITY|nmod|cell	Immunohistological expression of p53 in primary pT1 transitional cell bladder_cancer in relation to tumour progression .
23922206	0	pTAC5	83,88	HSP21	37,42	pTAC5	HSP21	827001(Tax:3702)	828881(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Chloroplast small heat_shock protein HSP21 interacts with plastid nucleoid protein pTAC5 and is essential for chloroplast development in Arabidopsis under heat stress .
20047310	0	pVHL	68,72	Aurora-A_kinase	84,99	pVHL	Aurora-A kinase	7428	6790	Gene	Gene	protein|amod|START_ENTITY protein|nmod|END_ENTITY	Experimental and computational studies indicate specific binding of pVHL protein to Aurora-A_kinase .
16819549	0	pVHL	19,23	UCP	7,10	pVHL	UCP	7428	7350	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis .
15998523	0	pVHL	61,65	p53	14,17	pVHL	p53	7428	7157	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|Expression Expression|nmod|END_ENTITY	Expression of p53 in renal_carcinoma cells is independent of pVHL .
15955559	0	pVHL	33,37	von_Hippel_Lindau	14,31	pVHL	von Hippel Lindau	7428	7428	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	Expression of von_Hippel_Lindau -LRB- pVHL -RRB- protein in placentae from normal pregnant women and women with preeclampsia .
20942275	0	pain	68,72	SP_6	38,42	SP 6	SP 6	80320	80320	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect on moxibustion at Sanyinjiao -LRB- SP_6 -RRB- for uterine contraction pain in labor : a randomized controlled trial -RSB- .
15024693	0	paired-like_homeobox_2B	26,49	PHOX2B	51,57	paired-like homeobox 2B	PHOX2B	8929	8929	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Germline mutations of the paired-like_homeobox_2B -LRB- PHOX2B -RRB- gene in neuroblastoma .
15949893	0	paired-like_homeobox_2B	26,49	PHOX2B	51,57	paired-like homeobox 2B	PHOX2B	8929	8929	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Germline mutations of the paired-like_homeobox_2B -LRB- PHOX2B -RRB- gene in neuroblastoma .
20084168	0	paired-like_homeodomain_3	76,101	PITX3	103,108	paired-like homeodomain 3	PITX3	100422803	100422803	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like_homeodomain_3 -LRB- PITX3 -RRB- gene .
24570025	0	paired_box_3	30,42	PAX3	44,48	paired box 3	PAX3	540951(Tax:9913)	540951(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	SNP and haplotype analysis of paired_box_3 -LRB- PAX3 -RRB- gene provide evidence for association with growth traits in Chinese cattle .
25277182	0	paired_box_5	45,57	PAX5	59,63	paired box 5	PAX5	5079	5079	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Applicability of the methylated_CpG sites of paired_box_5 -LRB- PAX5 -RRB- promoter for prediction the prognosis of gastric_cancer .
24251689	0	paired_box_7	27,39	PAX7	41,45	paired box 7	PAX7	395942(Tax:9031)	395942(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel 31-bp indel in the paired_box_7 -LRB- PAX7 -RRB- gene is associated with chicken performance traits .
22105368	0	paired_box_gene_5	27,44	p53	108,111	paired box gene 5	p53	5079	7157	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Epigenetic inactivation of paired_box_gene_5 , a novel tumor suppressor gene , through direct upregulation of p53 is associated with prognosis in gastric_cancer patients .
20572292	0	paired_box_gene_8	11,28	PAX8	30,34	paired box gene 8	PAX8	7849	7849	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Utility of paired_box_gene_8 -LRB- PAX8 -RRB- expression in fluid and fine-needle aspiration cytology : an immunohistochemical study of metastatic ovarian_serous_carcinoma .
22396535	0	paired_immunoglobulin-like_receptor_a	25,62	PILRa	64,69	paired immunoglobulin-like receptor a	PILRa	29992	29992	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Evolutionarily conserved paired_immunoglobulin-like_receptor_a -LRB- PILRa -RRB- domain mediates its interaction with diverse sialylated ligands .
21050850	0	palladin	56,64	Akt2	0,4	palladin	Akt2	27143	208	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Akt2 regulates expression of the actin-bundling protein palladin .
10649502	0	palmitoyl-protein_thioesterase-1	47,79	PPT1	81,85	palmitoyl-protein thioesterase-1	PPT1	5538	5538	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of three novel mutations of the palmitoyl-protein_thioesterase-1 -LRB- PPT1 -RRB- gene in children with neuronal_ceroid-lipofuscinosis .
25350780	0	pan-Tropomyosin_Receptor_Kinases	68,100	Trk	102,105	pan-Tropomyosin Receptor Kinases	Trk	59109(Tax:10116)	59109(Tax:10116)	Gene	Gene	Inhibitors|compound|START_ENTITY Inhibitors|appos|END_ENTITY	Syntheses and Evaluation of Carbon-11 - and Fluorine-18-Radiolabeled pan-Tropomyosin_Receptor_Kinases -LRB- Trk -RRB- Inhibitors : Exploration of the 4-aza-2-Oxindole Scaffold as Trk PET Imaging Agents .
1688389	1	pancreas-specific_protein	74,99	PASP	101,105	pancreas-specific protein	PASP	1360	1360	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Serum concentrations of pancreas-specific_protein -LRB- PASP -RRB- in acute_pancreatitis and other abdominal_diseases .
1370825	1	pancreas-specific_protein	92,117	procarboxypeptidase_B	132,153	pancreas-specific protein	procarboxypeptidase B	1360	1360	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of pancreas-specific_protein as pancreatic procarboxypeptidase_B .
15885879	0	pancreas_duodenum_homeobox-1	65,93	Bridge-1	16,24	pancreas duodenum homeobox-1	Bridge-1	29535(Tax:10116)	161475(Tax:10116)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	The coactivator Bridge-1 increases transcriptional activation by pancreas_duodenum_homeobox-1 -LRB- PDX-1 -RRB- .
20844005	0	pancreatic-derived_factor	33,58	PANDER	60,66	pancreatic-derived factor	PANDER	52793(Tax:10090)	52793(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Liver-specific overexpression of pancreatic-derived_factor -LRB- PANDER -RRB- induces fasting hyperglycemia in mice .
8244568	0	pancreatic-secretory-trypsin-inhibitor	27,65	PSTI	67,71	pancreatic-secretory-trypsin-inhibitor	PSTI	6690	6690	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Specific expression of the pancreatic-secretory-trypsin-inhibitor -LRB- PSTI -RRB- gene in hepatocellular_carcinoma .
22669743	0	pancreatic_and_duodenal_homeobox-1	23,57	somatostatin_receptor_subtype_5	61,92	pancreatic and duodenal homeobox-1	somatostatin receptor subtype 5	3651	6755	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of pancreatic_and_duodenal_homeobox-1 by somatostatin_receptor_subtype_5 .
21664946	0	pancreatic_derived_factor	16,41	FAM3B	43,48	pancreatic derived factor	FAM3B	52793(Tax:10090)	52793(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of pancreatic_derived_factor -LRB- FAM3B -RRB- expression in pancreatic b-cells by MCP-1 -LRB- CCL2 -RRB- .
21756815	0	pancreatic_derived_factor	81,106	glucagon-like_peptide-1	12,35	pancreatic derived factor	glucagon-like peptide-1	52793(Tax:10090)	14526(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of glucagon-like_peptide-1 on the free fatty_acid-induced expression of pancreatic_derived_factor in cultured b-TC3 cell line -RSB- .
20644547	0	pancreatic_duodenal_homeobox-1	32,62	AMPK	0,4	pancreatic duodenal homeobox-1	AMPK	29535(Tax:10116)	78975(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	AMPK enhances the expression of pancreatic_duodenal_homeobox-1 via PPARalpha , but not PPARgamma , in rat_insulinoma cell line INS-1 .
1783385	0	pancreatic_lipase	20,37	PNLIP	44,49	pancreatic lipase	PNLIP	5406	5406	Gene	Gene	gene|compound|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of human pancreatic_lipase gene -LRB- PNLIP -RRB- to chromosome 10q24-q26 .
7308593	0	pancreatic_polypeptide	15,37	CCK	51,54	pancreatic polypeptide	CCK	5539	885	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nsubj|release	The release of pancreatic_polypeptide by exogenous CCK in man and dog .
9124345	0	pancreatic_polypeptide	53,75	Motilin	0,7	pancreatic polypeptide	Motilin	490944(Tax:9615)	481748(Tax:9615)	Gene	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Motilin is a biosignal controlling cyclic release of pancreatic_polypeptide via the vagus in fasted dogs .
7782089	0	pancreatic_polypeptide	66,88	PPY	95,98	pancreatic polypeptide	PPY	5539	5539	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gene duplication of the human peptide_YY gene -LRB- PYY -RRB- generated the pancreatic_polypeptide gene -LRB- PPY -RRB- on chromosome 17q21 .1 .
6946754	0	pancreatic_polypeptide	20,42	Secretin	0,8	pancreatic polypeptide	Secretin	5539	6343	Gene	Gene	stimulated|xcomp|START_ENTITY END_ENTITY|acl|stimulated	Secretin stimulated pancreatic_polypeptide : a test for chronic_pancreatitis .
2465985	0	pancreatic_polypeptide	220,242	VIP	202,205	pancreatic polypeptide	VIP	5539	7432	Gene	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
2390922	0	pancreatic_polypeptide	57,79	cholecystokinin	8,23	pancreatic polypeptide	cholecystokinin	490944(Tax:9615)	609547(Tax:9615)	Gene	Gene	secretion|amod|START_ENTITY Role|nmod|secretion Role|nmod|END_ENTITY	Role of cholecystokinin in bombesin - and meal-stimulated pancreatic_polypeptide secretion in dogs .
6103802	0	pancreatic_polypeptide	58,80	gastrin	11,18	pancreatic polypeptide	gastrin	490944(Tax:9615)	100685087	Gene	Gene	levels|nmod|START_ENTITY circulating|dobj|levels END_ENTITY|acl|circulating	Effects of gastrin on circulating levels of somatostatin , pancreatic_polypeptide , and vasoactive intestinal peptide in dogs .
2760512	0	pancreatic_polypeptide	101,123	gastrin-releasing_peptide	27,52	pancreatic polypeptide	gastrin-releasing peptide	5539	2922	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of synthetic human gastrin-releasing_peptide on pancreatic exocrine secretion and release of pancreatic_polypeptide in conscious rats .
6622284	0	pancreatic_polypeptide	105,127	gastrin-releasing_peptide	28,53	pancreatic polypeptide	gastrin-releasing peptide	490944(Tax:9615)	610154(Tax:9615)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of synthetic porcine gastrin-releasing_peptide on plasma levels of immunoreactive cholecystokinin pancreatic_polypeptide and gastrin in dogs .
3501746	0	pancreatic_polypeptide	9,31	hCRF	44,48	pancreatic polypeptide	hCRF	5539	1392	Gene	Gene	response|amod|START_ENTITY response|acl|END_ENTITY	Impaired pancreatic_polypeptide response to hCRF in type 2 diabetics : restoration to normal by an opioid antagonist .
2373268	0	pancreatic_polypeptide	27,49	secretin	17,25	pancreatic polypeptide	secretin	5539	6343	Gene	Gene	START_ENTITY|nsubj|Cholecystokinin Cholecystokinin|appos|END_ENTITY	Cholecystokinin , secretin , pancreatic_polypeptide in relation to gallbladder dynamics and gastrointestinal interdigestive motility .
6997022	0	pancreatic_polypeptide	34,56	secretin	22,30	pancreatic polypeptide	secretin	5539	6343	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Stimulatory effect of secretin on pancreatic_polypeptide in diabetic patients .
2465985	0	pancreatic_polypeptide	220,242	substance_P	207,218	pancreatic polypeptide	substance P	5539	6863	Gene	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
2257226	0	pancreatic_secretory_trypsin_inhibitor	14,52	PSTI	54,58	pancreatic secretory trypsin inhibitor	PSTI	6690	6690	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- in colorectal_cancer .
2403744	0	pancreatic_secretory_trypsin_inhibitor	29,67	PSTI	69,73	pancreatic secretory trypsin inhibitor	PSTI	6690	6690	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study on pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- in gastric_carcinomas .
2436966	0	pancreatic_secretory_trypsin_inhibitor	25,63	PSTI	65,69	pancreatic secretory trypsin inhibitor	PSTI	6690	6690	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated levels of serum pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- in patients with malabsorption_syndrome .
2734496	0	pancreatic_secretory_trypsin_inhibitor	18,56	PSTI	58,62	pancreatic secretory trypsin inhibitor	PSTI	6690	6690	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	-LSB- Changes in serum pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- during and after heart surgery -RSB- .
16823394	0	pancreatic_secretory_trypsin_inhibitor	45,83	SPINK1	85,91	pancreatic secretory trypsin inhibitor	SPINK1	6690	6690	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of a large genomic deletion in the pancreatic_secretory_trypsin_inhibitor -LRB- SPINK1 -RRB- gene .
1669448	0	pancreatic_secretory_trypsin_inhibitor	34,72	leukocyte_elastase	90,108	pancreatic secretory trypsin inhibitor	leukocyte elastase	574092(Tax:9913)	1991	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of the bovine and porcine pancreatic_secretory_trypsin_inhibitor -LRB- Kazal -RRB- to human leukocyte_elastase : a thermodynamic study .
8631368	0	pancreatic_spasmolytic_Polypeptide	11,45	PSP	47,50	pancreatic spasmolytic Polypeptide	PSP	24714(Tax:10116)	24714(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of pancreatic_spasmolytic_Polypeptide -LRB- PSP -RRB- on epithelial cell function .
1429019	0	pancreatic_spasmolytic_polypeptide	36,70	PSP	72,75	pancreatic spasmolytic polypeptide	PSP	397420(Tax:9823)	397420(Tax:9823)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of pancreatic_spasmolytic_polypeptide -LRB- PSP -RRB- in the pig .
12757156	0	pancreatitis-associated_protein	18,49	PAP	51,54	pancreatitis-associated protein	PAP	5068	5068	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of pancreatitis-associated_protein -LRB- PAP -RRB- in human pancreatic_ductal_adenocarcinoma .
8188210	0	pancreatitis-associated_protein	83,114	PAP	116,119	pancreatitis-associated protein	PAP	5068	5068	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , genomic organization , and chromosomal localization of the human pancreatitis-associated_protein -LRB- PAP -RRB- gene .
8241280	0	pancreatitis_associated_protein_III	4,39	PAP	71,74	pancreatitis associated protein III	PAP	24620(Tax:10116)	24618(Tax:10116)	Gene	Gene	START_ENTITY|dep|member member|nmod|family family|compound|END_ENTITY	The pancreatitis_associated_protein_III -LRB- PAP_III -RRB- , a new member of the PAP gene family .
22553206	0	pannexin-1	105,115	P2X7_receptor	23,36	pannexin-1	P2X7 receptor	55991(Tax:10090)	18439(Tax:10090)	Gene	Gene	dependence|nmod|START_ENTITY reveal|dobj|dependence reveal|nsubj|variants variants|nmod|END_ENTITY	Splice variants of the P2X7_receptor reveal differential agonist dependence and functional coupling with pannexin-1 .
16758184	0	pantothenate-kinase-associated_neurodegeneration	44,92	Pantothenate_kinase_2	0,21	pantothenate-kinase-associated neurodegeneration	Pantothenate kinase 2	80025	80025	Gene	Gene	mutation|nmod|START_ENTITY mutation|nsubj|END_ENTITY	Pantothenate_kinase_2 mutation with classic pantothenate-kinase-associated_neurodegeneration without ` eye-of-the-tiger ' sign on MRI in a pair of siblings .
12095677	0	pantothenate_kinase	11,30	Pank1	32,37	pantothenate kinase	Pank1	75735(Tax:10090)	75735(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The murine pantothenate_kinase -LRB- Pank1 -RRB- gene encodes two differentially regulated pantothenate_kinase isozymes .
19787094	0	par14	32,37	parvulin	48,56	par14	parvulin	5303	5303	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Small family with key contacts : par14 and par17 parvulin proteins , relatives of pin1 , now emerge in biomedical research .
22158899	0	paracaspase	92,103	MALT1	85,90	paracaspase	MALT1	10892	10892	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Crystal structure of the mucosa-associated_lymphoid_tissue_lymphoma_translocation_1 -LRB- MALT1 -RRB- paracaspase region .
17551748	0	paracellin-1	47,59	claudin-16	61,71	paracellin-1	claudin-16	10686	10686	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Identification and subcellular localization of paracellin-1 -LRB- claudin-16 -RRB- in human salivary glands .
21454477	0	paracingulin	42,54	ZO-1	11,15	paracingulin	ZO-1	84952	7082	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells .
9637778	0	paraneoplastic_cerebellar_degeneration-associated_antigen	21,78	PKN	0,3	paraneoplastic cerebellar degeneration-associated antigen	PKN	1039	5585	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PKN interacts with a paraneoplastic_cerebellar_degeneration-associated_antigen , which is a potential transcription factor .
17533519	0	paraoxonase	12,23	PON	25,28	paraoxonase	PON	5444	5444	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of paraoxonase -LRB- PON -RRB- enzyme in the extent and severity of the coronary_artery_disease in type-2 diabetic patients .
20458968	0	paraoxonase	17,28	PON-1	30,35	paraoxonase	PON-1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Polymorphism of paraoxonase -LRB- PON-1 -RRB- gene in Slavonic part of Kharkiv population -RSB- .
10421480	0	paraoxonase	12,23	PON1	25,29	paraoxonase	PON1	5444	5444	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of paraoxonase -LRB- PON1 -RRB- in the detoxication of organophosphates and its human polymorphism .
10634137	0	paraoxonase	17,28	PON1	30,34	paraoxonase	PON1	5444	5444	Gene	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	Determination of paraoxonase -LRB- PON1 -RRB- status requires more than genotyping .
10669651	0	paraoxonase	32,43	PON1	44,48	paraoxonase	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations .
10856521	0	paraoxonase	39,50	PON1	52,56	paraoxonase	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism upstream from the human paraoxonase -LRB- PON1 -RRB- gene and its association with PON1 expression .
10894822	0	paraoxonase	38,49	PON1	50,54	paraoxonase	PON1	5444	5444	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|compound|END_ENTITY	MRI cerebral white_matter_lesions and paraoxonase PON1 polymorphisms : three-year follow-up of the austrian_stroke prevention study .
10923642	0	paraoxonase	38,49	PON1	50,54	paraoxonase	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Promoter polymorphism T -LRB- -107 -RRB- C of the paraoxonase PON1 gene is a risk factor for coronary_heart_disease in type 2 diabetic patients .
12742701	0	paraoxonase	12,23	PON1	25,29	paraoxonase	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Human serum paraoxonase -LRB- PON1 -RRB- activity in acute organophosphorous insecticide poisoning .
12777966	0	paraoxonase	20,31	PON1	33,37	paraoxonase	PON1	5444	5444	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human paraoxonase -LRB- PON1 -RRB- during development .
15653099	0	paraoxonase	15,26	PON1	28,32	paraoxonase	PON1	5444	5444	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Measurement of paraoxonase -LRB- PON1 -RRB- status as a potential biomarker of susceptibility to organophosphate_toxicity .
15670573	0	paraoxonase	14,25	PON1	27,31	paraoxonase	PON1	5444	5444	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Modulation of paraoxonase -LRB- PON1 -RRB- activity .
15995178	0	paraoxonase	19,30	PON1	32,36	paraoxonase	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The correlation of paraoxonase -LRB- PON1 -RRB- activity with lipid and lipoprotein levels differs with vascular_disease status .
16112327	0	paraoxonase	8,19	PON1	21,25	paraoxonase	PON1	18979(Tax:10090)	18979(Tax:10090)	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Role of paraoxonase -LRB- PON1 -RRB- status in pesticide sensitivity : genetic and temporal determinants .
17183021	0	paraoxonase	23,34	PON1	36,40	paraoxonase	PON1	5444	5444	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The association of the paraoxonase -LRB- PON1 -RRB- Q192R polymorphism with depression in older women : findings from the British Women 's Heart and Health Study .
19371607	0	paraoxonase	61,72	PON1	74,78	paraoxonase	PON1	5444	5444	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Risk of carotid_atherosclerosis is associated with low serum paraoxonase -LRB- PON1 -RRB- activity among arsenic exposed residents in Southwestern Taiwan .
9443862	0	paraoxonase	25,36	PON1	44,48	paraoxonase	PON1	5444	5444	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	DNA polymorphisms in two paraoxonase genes -LRB- PON1 and PON2 -RRB- are associated with the risk of coronary_heart_disease .
12618279	0	paraoxonase	2,13	PON_1	33,38	paraoxonase	PON 1	5444	5444	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A paraoxonase gene polymorphism , PON_1 -LRB- 55 -RRB- , as an independent risk factor for increased carotid intima-media_thickness in middle-aged women .
15704252	0	paraoxonase-1	59,72	PON1	74,78	paraoxonase-1	PON1	5444	5444	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Determinants of homocysteine-thiolactonase activity of the paraoxonase-1 -LRB- PON1 -RRB- protein in humans .
16323636	0	paraoxonase-1	109,122	PON1	124,128	paraoxonase-1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Effects of oxidative DNA damage induced by polycyclic_aromatic_hydrocarbons and genetic polymorphism of the paraoxonase-1 -LRB- PON1 -RRB- gene on lung_cancer -RSB- .
19750105	0	paraoxonase-1	47,60	PON1	62,66	paraoxonase-1	PON1	5444	5444	Gene	Gene	status|amod|START_ENTITY status|appos|END_ENTITY	Serum cholinesterase inhibition in relation to paraoxonase-1 -LRB- PON1 -RRB- status among organophosphate-exposed agricultural pesticide handlers .
24905310	0	paraoxonase-1	38,51	PON1	53,57	paraoxonase-1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of calcium channel blockers on paraoxonase-1 -LRB- PON1 -RRB- activity and oxidative stress .
26417268	0	paraoxonase-1	64,77	PON1	79,83	paraoxonase-1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Arylesterase activity is associated with antioxidant intake and paraoxonase-1 -LRB- PON1 -RRB- gene methylation in metabolic_syndrome patients following an energy restricted diet .
27012115	0	paraoxonase-1	17,30	PON1	32,36	paraoxonase-1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Tobacco smoking , paraoxonase-1 -LRB- PON1 -RRB- activity and pleiotropic effects of simvastatin treatment in patients with stable coronary_artery_disease -LRB- CAD -RRB- .
23958245	0	paraoxonase-1	35,48	apolipoprotein_E	63,79	paraoxonase-1	apolipoprotein E	5444	348	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The positive relationship of serum paraoxonase-1 activity with apolipoprotein_E is abrogated in metabolic_syndrome .
17900266	0	paraoxonase-3	25,38	PON3	40,44	paraoxonase-3	PON3	5446	5446	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the paraoxonase-3 -LRB- PON3 -RRB- gene is associated with serum PON1 activity .
25230879	0	paraoxonase_1	16,29	HDL3	0,4	paraoxonase 1	HDL3	18979(Tax:10090)	114576(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	HDL3 stimulates paraoxonase_1 antiatherogenic catalytic and biological activities in a macrophage model system : In vivo and in vitro studies .
23791833	0	paraoxonase_1	26,39	Interleukin-6	0,13	paraoxonase 1	Interleukin-6	5444	3569	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-6 upregulates paraoxonase_1 gene expression via an AKT/NF-kB-dependent pathway .
12957679	0	paraoxonase_1	24,37	Leptin	0,6	paraoxonase 1	Leptin	84024(Tax:10116)	25608(Tax:10116)	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Leptin decreases plasma paraoxonase_1 -LRB- PON1 -RRB- activity and induces oxidative stress : the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia .
25487823	0	paraoxonase_1	45,58	PON-2	107,112	paraoxonase 1	PON-2	5444	5445	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|END_ENTITY	Measurement of activity and concentration of paraoxonase_1 -LRB- PON-1 -RRB- in seminal plasma and identification of PON-2 in the sperm of boar ejaculates .
11151764	0	paraoxonase_1	23,36	PON1	43,47	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of human paraoxonase_1 gene -LRB- PON1 -RRB- and susceptibility to diabetic_nephropathy in type_I_diabetes_mellitus .
12545199	0	paraoxonase_1	60,73	PON1	75,79	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Species - and substrate-specific stimulation of human plasma paraoxonase_1 -LRB- PON1 -RRB- activity by high chloride concentration .
17136774	0	paraoxonase_1	41,54	PON1	56,60	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Sex-specific QTL effects on variation in paraoxonase_1 -LRB- PON1 -RRB- activity in Mexican Americans .
18349088	0	paraoxonase_1	16,29	PON1	31,35	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relationship of paraoxonase_1 -LRB- PON1 -RRB- gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk .
19347607	0	paraoxonase_1	91,104	PON1	106,110	paraoxonase 1	PON1	100048952(Tax:9823)	100048952(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence identification , chromosomal mapping and tissue specific expression of the porcine paraoxonase_1 -LRB- PON1 -RRB- gene .
20375196	0	paraoxonase_1	67,80	PON1	82,86	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic association between single nucleotide polymorphisms in the paraoxonase_1 -LRB- PON1 -RRB- gene and small-for-gestational-age birth in related and unrelated subjects .
21044882	0	paraoxonase_1	58,71	PON1	73,77	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Human carotid lesion linoleic_acid_hydroperoxide inhibits paraoxonase_1 -LRB- PON1 -RRB- activity via reaction with PON1 free sulfhydryl_cysteine 284 .
21093416	0	paraoxonase_1	42,55	PON1	57,61	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Pharmacological and dietary modulators of paraoxonase_1 -LRB- PON1 -RRB- activity and expression : the hunt goes on .
21229382	0	paraoxonase_1	47,60	PON1	62,66	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of L55M and Q192R polymorphisms in paraoxonase_1 -LRB- PON1 -RRB- gene with breast_cancer risk and their clinical significance .
21655055	0	paraoxonase_1	48,61	PON1	63,67	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of intronic and exonic polymorphisms of paraoxonase_1 -LRB- PON1 -RRB- gene on serum PON1 activity in a Korean population .
21783258	0	paraoxonase_1	83,96	PON1	98,102	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between bipolar_I_disorder and the L55M and Q192R polymorphisms of the paraoxonase_1 -LRB- PON1 -RRB- gene .
22266287	0	paraoxonase_1	14,27	PON1	29,33	paraoxonase 1	PON1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of paraoxonase_1 -LRB- PON1 -RRB- in PCB_126-exposed male Sprague_Dawley_rats .
22956172	0	paraoxonase_1	26,39	PON1	41,45	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulatory regions of the paraoxonase_1 -LRB- PON1 -RRB- gene are associated with neovascular age-related_macular_degeneration -LRB- AMD -RRB- .
23182497	0	paraoxonase_1	24,37	PON1	39,43	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Positive correlation of paraoxonase_1 -LRB- PON1 -RRB- activity with serum insulin level and HOMA-IR in dementia .
23376056	0	paraoxonase_1	71,84	PON1	86,90	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Plasma protein hydroperoxides during aging in humans : correlation with paraoxonase_1 -LRB- PON1 -RRB- arylesterase activity and plasma total thiols .
24143103	0	paraoxonase_1	14,27	PON1	29,33	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Reduced serum paraoxonase_1 -LRB- PON1 -RRB- activity in patients with schizophrenia treated with olanzapine but not quetiapine .
24971380	0	paraoxonase_1	14,27	PON1	29,33	paraoxonase 1	PON1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Age-dependent paraoxonase_1 -LRB- PON1 -RRB- activity and LDL oxidation in Wistar_rats during their entire lifespan .
25395020	0	paraoxonase_1	6,19	PON1	21,25	paraoxonase 1	PON1	475234(Tax:9615)	475234(Tax:9615)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Serum paraoxonase_1 -LRB- PON1 -RRB- activity in acute pancreatitis of dogs .
26021888	0	paraoxonase_1	89,102	PON1	104,108	paraoxonase 1	PON1	523798(Tax:9913)	523798(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of single nucleotide polymorphisms in the promoter region of the bovine paraoxonase_1 -LRB- PON1 -RRB- gene affecting serum enzyme activity in dairy cows .
26021888	0	paraoxonase_1	89,102	PON1	104,108	paraoxonase 1	PON1	523798(Tax:9913)	523798(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of single nucleotide polymorphisms in the promoter region of the bovine paraoxonase_1 -LRB- PON1 -RRB- gene affecting serum enzyme activity in dairy cows .
26123170	0	paraoxonase_1	8,21	PON1	23,27	paraoxonase 1	PON1	5444	5444	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Lowered paraoxonase_1 -LRB- PON1 -RRB- activity is associated with increased cytokine levels in drug na ve first_episode_psychosis .
27022137	0	paraoxonase_1	32,45	PON1	47,51	paraoxonase 1	PON1	5444	5444	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The common variant Q192R at the paraoxonase_1 -LRB- PON1 -RRB- gene and its activity are responsible for a portion of the altered antioxidant status in type_2_diabetes .
12369742	0	paraoxonase_1	160,173	PON_1	175,180	paraoxonase 1	PON 1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effect of peroxisome proliferator-activated receptors alpha -LRB- PPARalpha -RRB- agonist , fenofibrate , on lipid peroxidation , total antioxidant capacity , and plasma paraoxonase_1 -LRB- PON_1 -RRB- activity .
26434531	0	paraoxonase_1	36,49	PXR	53,56	paraoxonase 1	PXR	5444	8856	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of human paraoxonase_1 by PXR and GR in human hepatoma cells .
22155455	0	paraoxonase_1	51,64	Urokinase-type_plasminogen_activator	0,36	paraoxonase 1	Urokinase-type plasminogen activator	5444	5328	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Urokinase-type_plasminogen_activator downregulates paraoxonase_1 expression in hepatocytes by stimulating peroxisome_proliferator-activated_receptor-y nuclear export .
19887823	0	paraoxonase_1	33,46	adiponectin	16,27	paraoxonase 1	adiponectin	5444	9370	Gene	Gene	Associations|nmod|START_ENTITY Associations|nmod|END_ENTITY	Associations of adiponectin with paraoxonase_1 and sE-selectin in hemodialyzed patients .
18608549	0	paraoxonase_1	29,42	bean	15,19	paraoxonase 1	bean	5444	146227	Gene	Gene	activity|amod|START_ENTITY Effects|nmod|activity Effects|nmod|END_ENTITY	Effects of soy bean on serum paraoxonase_1 activity and lipoproteins in hyperlipidemic postmenopausal women .
24615737	0	paraoxonase_1	52,65	pon1	67,71	paraoxonase 1	pon1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	The effect of in vitro dieldrin exposure on the rat paraoxonase_1 -LRB- pon1 -RRB- promoter .
20728021	0	paraoxonase_1	23,36	sterol_regulatory_element_binding_protein_2	57,100	paraoxonase 1	sterol regulatory element binding protein 2	5444	6721	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Quercetin up-regulates paraoxonase_1 gene expression via sterol_regulatory_element_binding_protein_2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase_1 promoter in HuH7 liver cells .
16970920	0	paraoxonase_2	86,99	PON2	101,105	paraoxonase 2	PON2	5445	5445	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	A biphasic U-shape effect of cellular oxidative stress on the macrophage anti-oxidant paraoxonase_2 -LRB- PON2 -RRB- enzymatic activity .
17292903	0	paraoxonase_2	11,24	PON2	26,30	paraoxonase 2	PON2	5445	5445	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Macrophage paraoxonase_2 -LRB- PON2 -RRB- expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR_gamma and AP-1 pathway activation .
18020951	0	paraoxonase_2	11,24	PON2	26,30	paraoxonase 2	PON2	5445	5445	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Macrophage paraoxonase_2 -LRB- PON2 -RRB- expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- pathway .
19546579	0	paraoxonase_2	31,44	PON2	46,50	paraoxonase 2	PON2	5445	5445	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of polymorphisms in paraoxonase_2 -LRB- PON2 -RRB- gene and their association with cardiovascular-renal_disease risk in Mexican Americans .
23047827	0	paraoxonase_2	53,66	PON2	68,72	paraoxonase 2	PON2	5445	5445	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Triglyceride accumulation in macrophages upregulates paraoxonase_2 -LRB- PON2 -RRB- expression via ROS-mediated JNK/c-Jun signaling pathway activation .
18436804	0	paraoxonase_2	44,57	Urokinase_plasminogen_activator	0,31	paraoxonase 2	Urokinase plasminogen activator	330260(Tax:10090)	18792(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Urokinase_plasminogen_activator upregulates paraoxonase_2 expression in macrophages via an NADPH oxidase-dependent mechanism .
19426787	0	paraoxonase_3	66,79	PON3	81,85	paraoxonase 3	PON3	269823(Tax:10090)	269823(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization and expression analysis of the porcine paraoxonase_3 -LRB- PON3 -RRB- gene .
23269439	0	paraplegin	38,48	SPG7	32,36	paraplegin	SPG7	6687	6687	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The p.Ala510Val mutation in the SPG7 -LRB- paraplegin -RRB- gene is the most common mutation causing adult onset neurogenetic_disease in patients of British ancestry .
10702317	0	parathyroid_hormone	28,47	AUF1	18,22	parathyroid hormone	AUF1	24694(Tax:10116)	79256(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY END_ENTITY|nmod|mRNA	Identification of AUF1 as a parathyroid_hormone mRNA 3 ' - untranslated region-binding protein that determines parathyroid_hormone mRNA stability .
25049079	0	parathyroid_hormone	72,91	CITED1	54,60	parathyroid hormone	CITED1	19226(Tax:10090)	12705(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Nuclear translocation of CBP/p300-interacting protein CITED1 induced by parathyroid_hormone requires serine phosphorylation at position 79 in its 63-84 domain .
25907930	0	parathyroid_hormone	81,100	CITED1	110,116	parathyroid hormone	CITED1	19226(Tax:10090)	12705(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY signaling|dobj|pathway C|acl|signaling Activation|nmod|C enhances|nsubj|Activation enhances|dobj|expression expression|nummod|END_ENTITY	-LSB- Activation of phospholipase C-independent protein kinase C signaling pathway of parathyroid_hormone enhances CITED1 expression in mouse osteoblasts -RSB- .
954281	0	parathyroid_hormone	71,90	Calcitonin	0,10	parathyroid hormone	Calcitonin	24694(Tax:10116)	24241(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	Calcitonin and the bone fluid compartment : effect of calcitonin and/or parathyroid_hormone on plasma radiocalcium changes .
19147675	0	parathyroid_hormone	46,65	Cxcl1	14,19	parathyroid hormone	Cxcl1	24694(Tax:10116)	81503(Tax:10116)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	The chemokine Cxcl1 is a novel target gene of parathyroid_hormone -LRB- PTH -RRB- / PTH-related protein in committed osteoblasts .
16492667	0	parathyroid_hormone	61,80	ERK1/2	101,107	parathyroid hormone	ERK1/2	5741	5595;5594	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Distinct beta-arrestin - and G protein-dependent pathways for parathyroid_hormone receptor-stimulated ERK1/2 activation .
17038311	0	parathyroid_hormone	27,46	ERK1/2	146,152	parathyroid hormone	ERK1/2	5741	5595;5594	Gene	Gene	motifs|nmod|START_ENTITY motifs|parataxis|terminus terminus|xcomp|mediate mediate|dobj|scaffolding scaffolding|nmod|activation activation|amod|c-Src c-Src|nmod|beta-arrestin2 beta-arrestin2|nmod|END_ENTITY	Proline-rich motifs in the parathyroid_hormone -LRB- PTH -RRB- / PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation .
22414806	0	parathyroid_hormone	14,33	ERK1/2	108,114	parathyroid hormone	ERK1/2	5741	5595;5594	Gene	Gene	phosphorylation|amod|START_ENTITY Disruption|nmod|phosphorylation prolongs|nsubj|Disruption prolongs|xcomp|activation activation|nsubj|MAPK MAPK|compound|END_ENTITY	Disruption of parathyroid_hormone and parathyroid_hormone-related peptide receptor phosphorylation prolongs ERK1/2 MAPK activation and enhances c-fos expression .
16878432	0	parathyroid_hormone	23,42	Endothelin-1	0,12	parathyroid hormone	Endothelin-1	5741	1906	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Endothelin-1 regulates parathyroid_hormone expression of human parathyroid cells .
17911404	0	parathyroid_hormone	38,57	Fibroblast_growth_factor-23	0,27	parathyroid hormone	Fibroblast growth factor-23	5741	530239(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Fibroblast_growth_factor-23 regulates parathyroid_hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells .
18375760	0	parathyroid_hormone	25,44	G_protein-coupled_receptor	52,78	parathyroid hormone	G protein-coupled receptor	403986(Tax:9615)	491678(Tax:9615)	Gene	Gene	recognition|nmod|START_ENTITY recognition|nmod|END_ENTITY	Molecular recognition of parathyroid_hormone by its G_protein-coupled_receptor .
18165223	0	parathyroid_hormone	31,50	Interleukin-18	0,14	parathyroid hormone	Interleukin-18	24694(Tax:10116)	29197(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Interleukin-18 is regulated by parathyroid_hormone and is required for its bone anabolic actions .
10379905	0	parathyroid_hormone	44,63	Interleukin-6	0,13	parathyroid hormone	Interleukin-6	280903(Tax:9913)	280826(Tax:9913)	Gene	Gene	secretion|compound|START_ENTITY suppression|nmod|secretion induced|dobj|suppression induced|nsubj|END_ENTITY	Interleukin-6 induced suppression of bovine parathyroid_hormone secretion .
19306294	0	parathyroid_hormone	83,102	MGP	64,67	parathyroid hormone	MGP	19226(Tax:10090)	17313(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Sp proteins and Runx2 mediate regulation of matrix_gla_protein -LRB- MGP -RRB- expression by parathyroid_hormone .
21852324	0	parathyroid_hormone	118,137	Mitogen-activated_protein_kinase_phosphatase_1	0,46	parathyroid hormone	Mitogen-activated protein kinase phosphatase 1	19226(Tax:10090)	19252(Tax:10090)	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase_1 regulates bone mass , osteoblast gene expression , and responsiveness to parathyroid_hormone .
18784102	0	parathyroid_hormone	45,64	NHERF1	0,6	parathyroid hormone	NHERF1	5741	9368	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	NHERF1 mutations and responsiveness of renal parathyroid_hormone .
19505977	0	parathyroid_hormone	57,76	Osx	41,44	parathyroid hormone	Osx	24694(Tax:10116)	300260(Tax:10116)	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Regulation of osterix -LRB- Osx , Sp7 -RRB- and the Osx promoter by parathyroid_hormone in osteoblasts .
16765661	0	parathyroid_hormone	25,44	PGC-1alpha	0,10	parathyroid hormone	PGC-1alpha	24694(Tax:10116)	83516(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	PGC-1alpha is induced by parathyroid_hormone and coactivates Nurr1-mediated promoter activity in osteoblasts .
20558332	0	parathyroid_hormone	67,86	PT-r	127,131	parathyroid hormone	PT-r	5741	374308	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Involvement of GCMB in the transcriptional regulation of the human parathyroid_hormone gene in a parathyroid-derived cell line PT-r : effects of calcium and 1,25 -LRB- OH -RRB- 2D3 .
10784412	0	parathyroid_hormone	54,73	PTH	75,78	parathyroid hormone	PTH	5741	5741	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10965877	0	parathyroid_hormone	47,66	PTH	68,71	parathyroid hormone	PTH	405886(Tax:7955)	405886(Tax:7955)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Evaluating the ligand specificity of zebrafish parathyroid_hormone -LRB- PTH -RRB- receptors : comparison of PTH , PTH-related_protein , and tuberoinfundibular peptide of 39 residues .
11186329	0	parathyroid_hormone	48,67	PTH	69,72	parathyroid hormone	PTH	5741	5741	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Developmental and tissue-specific regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene expression .
1300345	0	parathyroid_hormone	15,34	PTH	36,39	parathyroid hormone	PTH	5741	5741	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of parathyroid_hormone -LRB- PTH -RRB- in genetic models of hypertension .
15762185	0	parathyroid_hormone	6,25	PTH	27,30	parathyroid hormone	PTH	5741	5741	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Serum parathyroid_hormone -LRB- PTH -RRB- levels in smokers and non-smokers .
16027955	0	parathyroid_hormone	23,42	PTH	44,47	parathyroid hormone	PTH	5741	5741	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Economic evaluation of parathyroid_hormone -LRB- PTH -RRB- in the treatment of osteoporosis in postmenopausal women .
1660713	0	parathyroid_hormone	28,47	PTH	49,52	parathyroid hormone	PTH	24694(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Specific down-regulation of parathyroid_hormone -LRB- PTH -RRB- receptors and responses to PTH by tumour_necrosis factor alpha and retinoic_acid in UMR 106-06 osteoblast-like osteosarcoma cells .
16944755	0	parathyroid_hormone	11,30	PTH	32,35	parathyroid hormone	PTH	5741	5741	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of parathyroid_hormone -LRB- PTH 1-34 -RRB- on hemopoiesis in long-term cultures of human bone marrow -RSB- .
19958930	0	parathyroid_hormone	46,65	PTH	67,70	parathyroid hormone	PTH	5741	5741	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Serum aldosterone is correlated positively to parathyroid_hormone -LRB- PTH -RRB- levels in patients with primary_hyperparathyroidism .
20451678	0	parathyroid_hormone	37,56	PTH	58,61	parathyroid hormone	PTH	5741	5741	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Hip fracture type : important role of parathyroid_hormone -LRB- PTH -RRB- response to hypovitaminosis D. OBJECTIVE : To investigate whether clinical and laboratory characteristics , including serum 25-hydroxyvitamin_D -LRB- 25 -LRB- OH -RRB- _ D -RRB- , PTH and parameters of mineral and bone metabolism , differ by hip_fracture -LRB- HF -RRB- type .
2155920	0	parathyroid_hormone	28,47	PTH	49,52	parathyroid hormone	PTH	396436(Tax:9031)	396436(Tax:9031)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Potent mitogenic effects of parathyroid_hormone -LRB- PTH -RRB- on embryonic chick and rabbit chondrocytes .
22722080	0	parathyroid_hormone	35,54	PTH	61,64	parathyroid hormone	PTH	5741	5741	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel homozygous mutation in the parathyroid_hormone gene -LRB- PTH -RRB- in a girl with isolated_hypoparathyroidism .
23240707	0	parathyroid_hormone	31,50	PTH	52,55	parathyroid hormone	PTH	5741	5741	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Digoxin-associated decrease in parathyroid_hormone -LRB- PTH -RRB- concentrations in patients with atrial_fibrillation .
23483040	0	parathyroid_hormone	59,78	PTH	80,83	parathyroid hormone	PTH	100351309(Tax:9986)	100351309(Tax:9986)	Gene	Gene	level|compound|START_ENTITY level|appos|END_ENTITY	Ultrasound exposure during pregnancy affects rabbit foetal parathyroid_hormone -LRB- PTH -RRB- level .
23533279	0	parathyroid_hormone	17,36	PTH	38,41	parathyroid hormone	PTH	19226(Tax:10090)	19226(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of parathyroid_hormone -LRB- PTH -RRB- receptor-1 phosphorylation in regulating acute responses to PTH .
3002757	0	parathyroid_hormone	19,38	PTH	40,43	parathyroid hormone	PTH	280903(Tax:9913)	280903(Tax:9913)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Down-regulation of parathyroid_hormone -LRB- PTH -RRB- receptors in cultured bone cells is associated with agonist-specific intracellular processing of PTH-receptor complexes .
6353628	0	parathyroid_hormone	6,25	PTH	32,35	parathyroid hormone	PTH	5741	5741	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human parathyroid_hormone gene -LRB- PTH -RRB- is on short arm of chromosome 11 .
8182566	0	parathyroid_hormone	10,29	PTH	31,34	parathyroid hormone	PTH	24694(Tax:10116)	24694(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of parathyroid_hormone -LRB- PTH -RRB- on replantation of amputated legs in a rat model .
8544835	0	parathyroid_hormone	36,55	PTH	57,60	parathyroid hormone	PTH	24694(Tax:10116)	24694(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Homolog-scanning mutagenesis of the parathyroid_hormone -LRB- PTH -RRB- receptor reveals PTH - -LRB- 1-34 -RRB- binding determinants in the third extracellular loop .
9075739	0	parathyroid_hormone	74,93	PTH	95,98	parathyroid hormone	PTH	5741	5741	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9645678	0	parathyroid_hormone	41,60	PTH	62,65	parathyroid hormone	PTH	19226(Tax:10090)	19226(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The effect of cell-matrix interaction on parathyroid_hormone -LRB- PTH -RRB- receptor binding and PTH responsiveness in proximal_renal_tubular_cells_and_osteoblast-like_cells .
9737342	0	parathyroid_hormone	46,65	PTH	67,70	parathyroid hormone	PTH	5741	5741	Gene	Gene	START_ENTITY|dobj|PTH-related_peptide PTH-related_peptide|appos|END_ENTITY	Lymphoblastoid interferon-alpha downregulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor expression in human osteoblastic cells -LRB- Saos-2 -RRB- .
10487664	0	parathyroid_hormone	8,27	PTH-related_peptide	34,53	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	novel|dep|START_ENTITY novel|dep|mutation mutation|amod|END_ENTITY	A novel parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor mutation in Jansen 's _ metaphyseal_chondrodysplasia .
10784412	0	parathyroid_hormone	54,73	PTH-related_peptide	80,99	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
10875241	0	parathyroid_hormone	73,92	PTH-related_peptide	99,118	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	promoters|nmod|START_ENTITY Dissection|dep|promoters Dissection|parataxis|gene gene|amod|END_ENTITY	Dissection of differentially regulated -LRB- G+C -RRB- - rich promoters of the human parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene .
11014383	0	parathyroid_hormone	20,39	PTH-related_peptide	46,65	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	Association|nmod|START_ENTITY Association|dep|polymorphism polymorphism|amod|END_ENTITY	Association between parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene polymorphism and the extent of bone mass reduction in primary_hyperparathyroidism .
11159842	0	parathyroid_hormone	43,62	PTH-related_peptide	69,88	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	START_ENTITY|dep|receptor receptor|amod|END_ENTITY	Tuberoinfundibular peptide 39 binds to the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor , but functions as an antagonist .
11181543	0	parathyroid_hormone	22,41	PTH-related_peptide	48,67	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	Signal-selectivity|nmod|START_ENTITY Signal-selectivity|parataxis|immortalized immortalized|nsubj|regulation regulation|amod|END_ENTITY	Signal-selectivity of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor-mediated regulation of differentiation in conditionally immortalized growth-plate chondrocytes .
11186329	0	parathyroid_hormone	48,67	PTH-related_peptide	74,93	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	regulation|nmod|START_ENTITY /|nsubj|regulation /|dobj|expression expression|amod|END_ENTITY	Developmental and tissue-specific regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene expression .
7721741	0	parathyroid_hormone	54,73	PTH-related_peptide	80,99	parathyroid hormone	PTH-related peptide	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	Truncation|nmod|START_ENTITY Truncation|parataxis|enhances enhances|nsubj|receptor receptor|amod|END_ENTITY	Truncation of the carboxyl-terminal region of the rat parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C .
7745008	0	parathyroid_hormone	93,112	PTH-related_peptide	119,138	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	START_ENTITY|dep|gene gene|amod|END_ENTITY	Pseudohypoparathyroidism_type_Ib is not caused by mutations in the coding exons of the human parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene .
8137752	0	parathyroid_hormone	58,77	PTH-related_peptide	84,103	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	down-regulation|nmod|START_ENTITY Role|nmod|down-regulation Role|dep|acid acid|amod|END_ENTITY	Role of protein kinase-A in homologous down-regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells .
8275958	0	parathyroid_hormone	14,33	PTH-related_peptide	40,59	parathyroid hormone	PTH-related peptide	280903(Tax:9913)	286767(Tax:9913)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|acid acid|amod|END_ENTITY	Regulation of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2 .8 and OK cells .
8299582	0	parathyroid_hormone	47,66	PTH-related_peptide	73,92	parathyroid hormone	PTH-related peptide	24694(Tax:10116)	5744	Gene	Gene	region|nmod|START_ENTITY region|dep|determines determines|nsubj|receptor receptor|amod|END_ENTITY	The extracellular amino-terminal region of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor determines the binding affinity for carboxyl-terminal fragments of PTH - -LRB- 1-34 -RRB- .
8386606	0	parathyroid_hormone	25,44	PTH-related_peptide	51,70	parathyroid hormone	PTH-related peptide	399502(Tax:9823)	24695(Tax:10116)	Gene	Gene	expressed|dobj|START_ENTITY Cloned|acl|expressed Cloned|parataxis|activate activate|nsubj|receptors receptors|amod|END_ENTITY	Cloned , stably expressed parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells .
8732687	0	parathyroid_hormone	32,51	PTH-related_peptide	58,77	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	G_alpha_q|dobj|START_ENTITY receptors|dep|G_alpha_q receptors|compound|END_ENTITY	G_alpha_q family members couple parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide and calcitonin receptors to phospholipase C in COS-7 cells .
8969199	0	parathyroid_hormone	61,80	PTH-related_peptide	87,106	parathyroid hormone	PTH-related peptide	100462909	100462910	Gene	Gene	loop|nmod|START_ENTITY region|nmod|loop signal|nsubj|region signal|parataxis|critical critical|nsubj|receptor receptor|amod|END_ENTITY	The N-terminal region of the third intracellular loop of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor is critical for coupling to cAMP and inositol_phosphate / Ca2 + signal transduction pathways .
8977437	0	parathyroid_hormone	32,51	PTH-related_peptide	58,77	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	expression|nmod|START_ENTITY expression|dep|gene gene|amod|END_ENTITY	Cell-specific expression of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene in kidney from kidney-specific and ubiquitous promoters .
9075739	0	parathyroid_hormone	74,93	PTH-related_peptide	100,119	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9727064	0	parathyroid_hormone	36,55	PTH-related_peptide	62,81	parathyroid hormone	PTH-related peptide	5741	5744	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|dep|expression expression|amod|END_ENTITY	Developmental upregulation of human parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide receptor gene expression from conserved and human-specific promoters .
23235147	0	parathyroid_hormone	44,63	PTH-related_peptide_receptor	70,98	parathyroid hormone	PTH-related peptide receptor	19226(Tax:10090)	19228(Tax:10090)	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	The IRE1a-XBP1 pathway positively regulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide_receptor expression and is involved in pth-induced osteoclastogenesis .
25505558	0	parathyroid_hormone	166,185	PTH1	186,190	parathyroid hormone	PTH1	5741	5741	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Green fluorescent protein fused to peptide agonists of two dissimilar G protein-coupled receptors : novel ligands of the bradykinin B2 -LRB- rhodopsin family -RRB- receptor and parathyroid_hormone PTH1 -LRB- secretin family -RRB- receptor .
10497171	0	parathyroid_hormone	29,48	PTH1R	95,100	parathyroid hormone	PTH1R	405886(Tax:7955)	5745	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Zebrafish express the common parathyroid_hormone / parathyroid_hormone-related peptide receptor -LRB- PTH1R -RRB- and a novel receptor -LRB- PTH3R -RRB- that is preferentially activated by mammalian and fugufish parathyroid_hormone-related peptide .
26647715	0	parathyroid_hormone	7,26	PTH1R	94,99	parathyroid hormone	PTH1R	280903(Tax:9913)	507783(Tax:9913)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|advcl|modulating modulating|nmod|END_ENTITY	Bovine parathyroid_hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R .
7797535	0	parathyroid_hormone	79,98	PTH2_receptor	104,117	parathyroid hormone	PTH2 receptor	5741	5746	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Identification and functional expression of a receptor selectively recognizing parathyroid_hormone , the PTH2_receptor .
20156969	0	parathyroid_hormone	48,67	PTHR1	42,47	parathyroid hormone	PTHR1	5741	5745	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Immunohistochemical identification of the PTHR1 parathyroid_hormone receptor in normal and neoplastic human tissues .
10479735	0	parathyroid_hormone	26,45	PTHrP	73,78	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	studies|nmod|START_ENTITY studies|parataxis|point-mutated point-mutated|nsubj|PTH-related_protein PTH-related_protein|appos|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrP -RRB- point-mutated hybrids .
10784412	0	parathyroid_hormone	54,73	PTHrP	101,106	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel Van91 I polymorphism in the 1st intron of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene and its effect on the urinary cAMP response to PTH .
11435617	0	parathyroid_hormone	12,31	PTHrP	144,149	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|dep|receptor receptor|appos|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
7857076	0	parathyroid_hormone	42,61	PTHrP	104,109	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	synthesis|nmod|START_ENTITY hormone|compound|synthesis hormone|appos|END_ENTITY	-LSB- Regulation of synthesis and secretion of parathyroid_hormone -LRB- PTH -RRB- and of tumor hypercalcemia hormone -LRB- PTHrP -RRB- -RSB- .
9075739	0	parathyroid_hormone	74,93	PTHrP	121,126	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tissue-specific transcription start sites and alternative splicing of the parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor gene : a new PTH/PTHrP _ receptor splice variant that lacks the signal peptide .
9660083	0	parathyroid_hormone	54,73	PTHrP	101,106	parathyroid hormone	PTHrP	24694(Tax:10116)	24695(Tax:10116)	Gene	Gene	START_ENTITY|dep|mRNA mRNA|appos|END_ENTITY	Pamidronate corrects the down-regulation of the renal parathyroid_hormone -LRB- PTH -RRB- / PTH-related peptide -LRB- PTHrP -RRB- receptor mRNA in rats bearing Walker_tumors .
9737342	0	parathyroid_hormone	46,65	PTHrP	93,98	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	START_ENTITY|dobj|PTH-related_peptide PTH-related_peptide|appos|END_ENTITY	Lymphoblastoid interferon-alpha downregulates parathyroid_hormone -LRB- PTH -RRB- / PTH-related_peptide -LRB- PTHrP -RRB- receptor expression in human osteoblastic cells -LRB- Saos-2 -RRB- .
9747354	0	parathyroid_hormone	123,142	PTHrP	143,148	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	not|nmod|START_ENTITY not|parataxis|END_ENTITY	Human keratinocytes express transcripts for three isoforms of parathyroid_hormone-related protein -LRB- PTHrP -RRB- , but not for the parathyroid_hormone / PTHrP receptor : effects of 1,25 -LRB- OH -RRB- 2_vitamin_D3 .
9747354	0	parathyroid_hormone	123,142	PTHrP	99,104	parathyroid hormone	PTHrP	5741	5744	Gene	Gene	not|nmod|START_ENTITY express|dep|not express|nmod|isoforms isoforms|nmod|protein protein|appos|END_ENTITY	Human keratinocytes express transcripts for three isoforms of parathyroid_hormone-related protein -LRB- PTHrP -RRB- , but not for the parathyroid_hormone / PTHrP receptor : effects of 1,25 -LRB- OH -RRB- 2_vitamin_D3 .
10951329	0	parathyroid_hormone	26,45	PTHrp	73,78	parathyroid hormone	PTHrp	5741	5744	Gene	Gene	studies|nmod|START_ENTITY studies|parataxis|peptides peptides|nsubj|PTH-related_protein PTH-related_protein|appos|END_ENTITY	Conformational studies of parathyroid_hormone -LRB- PTH -RRB- / PTH-related_protein -LRB- PTHrp -RRB- chimeric peptides .
19770518	0	parathyroid_hormone	15,34	Pin1	0,4	parathyroid hormone	Pin1	19226(Tax:10090)	23988(Tax:10090)	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Pin1 regulates parathyroid_hormone mRNA stability .
26297833	0	parathyroid_hormone	72,91	Pregnancy-associated_plasma_protein-A	0,37	parathyroid hormone	Pregnancy-associated plasma protein-A	19226(Tax:10090)	18491(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY modulates|dobj|effects modulates|nsubj|END_ENTITY	Pregnancy-associated_plasma_protein-A modulates the anabolic effects of parathyroid_hormone in mouse bone .
6149694	0	parathyroid_hormone	25,44	Prolactin	0,9	parathyroid hormone	Prolactin	280903(Tax:9913)	280901(Tax:9913)	Gene	Gene	secretion|amod|START_ENTITY stimulation|nmod|secretion stimulation|compound|END_ENTITY	Prolactin stimulation of parathyroid_hormone secretion in bovine parathyroid cells .
7263847	0	parathyroid_hormone	38,57	Prolactin	0,9	parathyroid hormone	Prolactin	5741	5617	Gene	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Prolactin and calcitonin responses to parathyroid_hormone infusion in hypoparathyroid , pseudohypoparathyroid , and normal subjects .
22190112	0	parathyroid_hormone	28,47	RANKL	10,15	parathyroid hormone	RANKL	19226(Tax:10090)	21943(Tax:10090)	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Sustained RANKL response to parathyroid_hormone in oncostatin_M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo .
11573967	0	parathyroid_hormone	45,64	RGS2	10,14	parathyroid hormone	RGS2	24694(Tax:10116)	84583(Tax:10116)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Inducible RGS2 is a cross-talk regulator for parathyroid_hormone signaling in rat osteoblast-like UMR106 cells .
744127	0	parathyroid_hormone	17,36	Renin	0,5	parathyroid hormone	Renin	403986(Tax:9615)	403838(Tax:9615)	Gene	Gene	release|nmod|START_ENTITY release|nsubj|END_ENTITY	Renin release by parathyroid_hormone in the dog .
820704	0	parathyroid_hormone	38,57	Somatostatin	0,12	parathyroid hormone	Somatostatin	5741	6750	Gene	Gene	suppress|dobj|START_ENTITY suppress|nsubj|END_ENTITY	Somatostatin does not suppress plasma parathyroid_hormone .
21576356	0	parathyroid_hormone	69,88	TRPV5	45,50	parathyroid hormone	TRPV5	5741	56302	Gene	Gene	mechanisms|nmod|START_ENTITY mechanisms|nmod|END_ENTITY	Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid_hormone .
7736322	0	parathyroid_hormone	54,73	TWY	134,137	parathyroid hormone	TWY	19226(Tax:10090)	18605(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Elevation of alkaline phosphatase activity induced by parathyroid_hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY -LRB- twy/twy -RRB- .
16088955	0	parathyroid_hormone	64,83	amphiregulin	15,27	parathyroid hormone	amphiregulin	5741	374	Gene	Gene	cells|nmod|START_ENTITY expression|nmod|cells expression|compound|END_ENTITY	Stimulation of amphiregulin expression in osteoblastic cells by parathyroid_hormone requires the protein kinase A and cAMP response element-binding protein signaling pathway .
11226426	0	parathyroid_hormone	57,76	androgen_receptor	85,102	parathyroid hormone	androgen receptor	19226(Tax:10090)	11835(Tax:10090)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nmod|END_ENTITY	Testosterone inhibits osteoclast formation stimulated by parathyroid_hormone through androgen_receptor .
10067851	0	parathyroid_hormone	43,62	c-fos	23,28	parathyroid hormone	c-fos	5741	2353	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Increased osteoblastic c-fos expression by parathyroid_hormone requires protein kinase A phosphorylation of the cyclic_adenosine_3 ' ,5 ' - monophosphate response element-binding protein at serine 133 .
10318853	1	parathyroid_hormone	161,180	c-fos	89,94	parathyroid hormone	c-fos	5741	2353	Gene	Gene	pathway|amod|START_ENTITY potentiated|nmod|pathway potentiated|nsubjpass|induction induction|nmod|proto-oncogene proto-oncogene|amod|END_ENTITY	Their weak induction of the c-fos proto-oncogene via Ca2 + mobilization is strongly potentiated by a parathyroid_hormone / cAMP-dependent protein kinase pathway independently of mitogen-activated protein kinase .
10366042	0	parathyroid_hormone	40,59	c-fos	18,23	parathyroid hormone	c-fos	19226(Tax:10090)	14281(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|gene gene|amod|END_ENTITY	Expression of the c-fos gene induced by parathyroid_hormone in the bones of SAMP6 mice , a murine model for senile_osteoporosis .
7962120	0	parathyroid_hormone	54,73	c-fos	30,35	parathyroid hormone	c-fos	5741	2353	Gene	Gene	signaling|nmod|START_ENTITY signaling|nmod|induction induction|amod|END_ENTITY	Second messenger signaling of c-fos gene induction by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_peptide in osteoblastic_osteosarcoma cells : its role in osteoblast proliferation and osteoclast-like cell formation .
8854242	0	parathyroid_hormone	39,58	c-fos	75,80	parathyroid hormone	c-fos	5741	2353	Gene	Gene	START_ENTITY|xcomp|activate activate|dobj|gene gene|amod|END_ENTITY	Analysis of signaling pathways used by parathyroid_hormone to activate the c-fos gene in human SaOS2 osteoblast-like cells .
9389528	0	parathyroid_hormone	55,74	c-fos	15,20	parathyroid hormone	c-fos	19226(Tax:10090)	14281(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Proto-oncogene c-fos is transcriptionally regulated by parathyroid_hormone -LRB- PTH -RRB- and PTH-related_protein in a cyclic_adenosine_monophosphate-dependent manner in osteoblastic cells .
10940742	0	parathyroid_hormone	77,96	calcium-sensing_receptor	42,66	parathyroid hormone	calcium-sensing receptor	5741	846	Gene	Gene	secretion|amod|START_ENTITY gene|nmod|secretion gene|amod|END_ENTITY	Association of polymorphic alleles of the calcium-sensing_receptor gene with parathyroid_hormone secretion in hemodialysis patients .
12671051	0	parathyroid_hormone	87,106	calcium-sensing_receptor	4,28	parathyroid hormone	calcium-sensing receptor	19226(Tax:10090)	12374(Tax:10090)	Gene	Gene	homeostasis|nmod|START_ENTITY required|nmod|homeostasis required|nsubjpass|END_ENTITY	The calcium-sensing_receptor is required for normal calcium homeostasis independent of parathyroid_hormone .
15775479	0	parathyroid_hormone	82,101	calcium-sensing_receptor	25,49	parathyroid hormone	calcium-sensing receptor	5741	846	Gene	Gene	-RSB-|amod|START_ENTITY secretion|nmod|-RSB- cause|dobj|secretion cause|nsubj|mutations mutations|nmod|END_ENTITY	-LSB- Activating mutations of calcium-sensing_receptor cause insufficient secretion of parathyroid_hormone -RSB- .
16189180	0	parathyroid_hormone	129,148	calcium-sensing_receptor	33,57	parathyroid hormone	calcium-sensing receptor	19226(Tax:10090)	12374(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY suppressing|dobj|secretion parathyroid|advcl|suppressing parathyroid|dobj|expression expression|amod|END_ENTITY	Relationship between parathyroid calcium-sensing_receptor expression and potency of the calcimimetic , cinacalcet , in suppressing parathyroid_hormone secretion in an in vivo murine model of primary_hyperparathyroidism .
16983178	0	parathyroid_hormone	10,29	calcium-sensing_receptor	128,152	parathyroid hormone	calcium-sensing receptor	5741	846	Gene	Gene	administration|amod|START_ENTITY Effect|nmod|administration caused|nsubj|Effect caused|nmod|mutation mutation|nmod|END_ENTITY	Effect of parathyroid_hormone administration in a patient with severe hypoparathyroidism caused by gain-of-function mutation of calcium-sensing_receptor .
19397786	0	parathyroid_hormone	39,58	calcium-sensing_receptor	4,28	parathyroid hormone	calcium-sensing receptor	5741	846	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The calcium-sensing_receptor regulates parathyroid_hormone gene expression in transfected HEK293 cells .
19474191	0	parathyroid_hormone	125,144	calcium-sensing_receptor	16,40	parathyroid hormone	calcium-sensing receptor	19226(Tax:10090)	12374(Tax:10090)	Gene	Gene	vivo|nmod|START_ENTITY dampens|nmod|vivo dampens|nsubj|END_ENTITY	The full-length calcium-sensing_receptor dampens the calcemic response to 1alpha ,25 -LRB- OH -RRB- 2_vitamin_D3 in vivo independently of parathyroid_hormone .
19797241	0	parathyroid_hormone	101,120	calcium-sensing_receptor	4,28	parathyroid hormone	calcium-sensing receptor	19226(Tax:10090)	12374(Tax:10090)	Gene	Gene	secretion|amod|START_ENTITY regulation|nmod|secretion hypercalcemia|nmod|regulation defends|nmod|hypercalcemia defends|nsubj|END_ENTITY	The calcium-sensing_receptor -LRB- CaSR -RRB- defends against hypercalcemia independently of its regulation of parathyroid_hormone secretion .
21306167	0	parathyroid_hormone	106,125	calcium-sensing_receptor	44,68	parathyroid hormone	calcium-sensing receptor	24694(Tax:10116)	24247(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY stimulate|dobj|secretion Discovery|acl:relcl|stimulate Discovery|nmod|antagonists antagonists|amod|END_ENTITY	Discovery of novel and potent orally active calcium-sensing_receptor antagonists that stimulate pulselike parathyroid_hormone secretion : synthesis and structure-activity relationships of tetrahydropyrazolopyrimidine derivatives .
21810422	0	parathyroid_hormone	84,103	calcium-sensing_receptor	26,50	parathyroid hormone	calcium-sensing receptor	24694(Tax:10116)	24247(Tax:10116)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|JTT-305 JTT-305|appos|antagonist antagonist|amod|END_ENTITY	JTT-305 , an orally active calcium-sensing_receptor antagonist , stimulates transient parathyroid_hormone release and bone formation in ovariectomized rats .
837869	0	parathyroid_hormone	47,66	gastrin	15,22	parathyroid hormone	gastrin	399502(Tax:9823)	445524(Tax:9823)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of gastrin secretion in the pig by parathyroid_hormone and its inhibition by thyrocalcitonin .
9693065	0	parathyroid_hormone	31,50	hPTH	52,56	parathyroid hormone	hPTH	5741	5741	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	High-level production of human parathyroid_hormone -LRB- hPTH -RRB- by induced expression in Saccharomyces_cerevisiae .
21274331	0	parathyroid_hormone	87,106	insulin-like_growth_factor_binding_protein-4	12,56	parathyroid hormone	Insulin-like growth factor binding protein-4	5741	3487	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Circulating insulin-like_growth_factor_binding_protein-4 -LRB- IGFBP-4 -RRB- is not regulated by parathyroid_hormone and vitamin_D in vivo : evidence from children with rickets .
15956342	0	parathyroid_hormone	75,94	insulin-like_growth_factor_binding_protein-5	18,62	parathyroid hormone	insulin-like growth factor binding protein-5	24694(Tax:10116)	25285(Tax:10116)	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Activation of the insulin-like_growth_factor_binding_protein-5 promoter by parathyroid_hormone in osteosarcoma cells requires activation of an activated protein-2 element .
10804018	0	parathyroid_hormone	60,79	interleukin-6	32,45	parathyroid hormone	interleukin-6	24694(Tax:10116)	24498(Tax:10116)	Gene	Gene	kinase|nmod|START_ENTITY kinase|nmod|production production|amod|END_ENTITY	Protein kinase C involvement in interleukin-6 production by parathyroid_hormone and tumor_necrosis_factor-alpha in UMR-106 osteoblastic cells .
11450697	0	parathyroid_hormone	41,60	interleukin-6	15,28	parathyroid hormone	interleukin-6	24694(Tax:10116)	24498(Tax:10116)	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Stimulation of interleukin-6 promoter by parathyroid_hormone , tumor_necrosis_factor_alpha , and interleukin-1beta in UMR-106 osteoblastic cells is inhibited by protein_kinase_C antagonists .
12412787	0	parathyroid_hormone	120,139	interleukin-6	12,25	parathyroid hormone	interleukin-6	5741	3569	Gene	Gene	increased|advcl|START_ENTITY increased|nsubj|Role Role|nmod|system system|amod|END_ENTITY	Role of the interleukin-6 / interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid_hormone in perimenopausal women .
12412787	0	parathyroid_hormone	120,139	interleukin-6	26,39	parathyroid hormone	interleukin-6	5741	3569	Gene	Gene	increased|advcl|START_ENTITY increased|nsubj|Role Role|nmod|system system|amod|END_ENTITY	Role of the interleukin-6 / interleukin-6 soluble receptor cytokine system in mediating increased skeletal sensitivity to parathyroid_hormone in perimenopausal women .
8631918	0	parathyroid_hormone	15,34	interleukin-6	38,51	parathyroid hormone	interleukin-6	5741	3569	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Stimulation by parathyroid_hormone of interleukin-6 and leukemia_inhibitory_factor expression in osteoblasts is an immediate-early gene response induced by cAMP signal transduction .
8725172	0	parathyroid_hormone	27,46	interleukin-6	126,139	parathyroid hormone	interleukin-6	19226(Tax:10090)	16193(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY stimulate|nsubj|protein stimulate|nmod|osteoblasts osteoblasts|nmod|END_ENTITY	In vivo demonstration that parathyroid_hormone and parathyroid_hormone-related protein stimulate expression by osteoblasts of interleukin-6 and leukemia_inhibitory_factor .
9169347	0	parathyroid_hormone	46,65	interleukin-6	93,106	parathyroid hormone	interleukin-6	5741	3569	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Involvement of different second messengers in parathyroid_hormone - and interleukin-1-induced interleukin-6 and interleukin-11 production in human bone marrow stromal cells .
9989817	0	parathyroid_hormone	95,114	interstitial_collagenase	67,91	parathyroid hormone	interstitial collagenase	19226(Tax:10090)	17386(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nmod|induction induction|nmod|END_ENTITY	Both AP-1 and Cbfa1-like factors are required for the induction of interstitial_collagenase by parathyroid_hormone .
16612082	0	parathyroid_hormone	30,49	matrix_Gla_protein	8,26	parathyroid hormone	matrix Gla protein	19226(Tax:10090)	17313(Tax:10090)	Gene	Gene	inhibition|amod|START_ENTITY Role|nmod|inhibition Role|nmod|END_ENTITY	Role of matrix_Gla_protein in parathyroid_hormone inhibition of osteoblast mineralization .
19306294	0	parathyroid_hormone	83,102	matrix_gla_protein	44,62	parathyroid hormone	matrix gla protein	19226(Tax:10090)	17313(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Sp proteins and Runx2 mediate regulation of matrix_gla_protein -LRB- MGP -RRB- expression by parathyroid_hormone .
1333875	0	parathyroid_hormone	41,60	ornithine_decarboxylase	14,37	parathyroid hormone	ornithine decarboxylase	24694(Tax:10116)	24609(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of ornithine_decarboxylase by parathyroid_hormone in osteoblastic cell systems .
1654784	0	parathyroid_hormone	11,30	ornithine_decarboxylase	34,57	parathyroid hormone	ornithine decarboxylase	5741	4953	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|activity activity|amod|END_ENTITY	Effects of parathyroid_hormone on ornithine_decarboxylase activity in human osteosarcoma cells .
11454517	0	parathyroid_hormone	6,25	osteoprotegerin	91,106	parathyroid hormone	osteoprotegerin	5741	4982	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|expression expression|nmod|END_ENTITY	Serum parathyroid_hormone , but not menopausal status , is associated with the expression of osteoprotegerin and RANKL mRNA in human bone samples .
11746511	0	parathyroid_hormone	83,102	osteoprotegerin	122,137	parathyroid hormone	osteoprotegerin	24694(Tax:10116)	25341(Tax:10116)	Gene	Gene	START_ENTITY|dobj|inhibition inhibition|nmod|expression expression|amod|END_ENTITY	Identification of signal transduction pathways and promoter sequences that mediate parathyroid_hormone 1-38 inhibition of osteoprotegerin gene expression .
16137047	0	parathyroid_hormone	12,31	osteoprotegerin	35,50	parathyroid hormone	osteoprotegerin	5741	4982	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of parathyroid_hormone on osteoprotegerin expression and osteoprotegerin_ligand and their related cytokines in human osteoblasts -RSB- .
23682129	0	parathyroid_hormone	79,98	osterix	18,25	parathyroid hormone	osterix	5741	121340	Gene	Gene	promoter|nmod|START_ENTITY promoter|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of the osterix -LRB- Osx , Sp7 -RRB- promoter by osterix and its inhibition by parathyroid_hormone .
23682129	0	parathyroid_hormone	79,98	osterix	49,56	parathyroid hormone	osterix	5741	121340	Gene	Gene	promoter|nmod|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the osterix -LRB- Osx , Sp7 -RRB- promoter by osterix and its inhibition by parathyroid_hormone .
11098049	0	parathyroid_hormone	91,110	p38	33,36	parathyroid hormone	p38	5741	1432	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid_hormone .
23291186	0	parathyroid_hormone	50,69	paraoxonase-1	8,21	parathyroid hormone	paraoxonase-1	19226(Tax:10090)	18979(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|effects effects|amod|END_ENTITY	Role of paraoxonase-1 in bone anabolic effects of parathyroid_hormone in hyperlipidemic mice .
14739849	0	parathyroid_hormone	14,33	parathyroid_hormone	67,86	parathyroid hormone	parathyroid hormone	5741	5741	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Comparison of parathyroid_hormone levels from the intact and whole parathyroid_hormone assays after parathyroidectomy for primary and secondary hyperparathyroidism .
14739849	0	parathyroid_hormone	67,86	parathyroid_hormone	14,33	parathyroid hormone	parathyroid hormone	5741	5741	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Comparison of parathyroid_hormone levels from the intact and whole parathyroid_hormone assays after parathyroidectomy for primary and secondary hyperparathyroidism .
15157563	0	parathyroid_hormone	15,34	parathyroid_hormone	54,73	parathyroid hormone	parathyroid hormone	5741	5741	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|END_ENTITY	Measurement of parathyroid_hormone and application of parathyroid_hormone in intraoperative monitoring .
15157563	0	parathyroid_hormone	54,73	parathyroid_hormone	15,34	parathyroid hormone	parathyroid hormone	5741	5741	Gene	Gene	Measurement|nmod|START_ENTITY Measurement|nmod|END_ENTITY	Measurement of parathyroid_hormone and application of parathyroid_hormone in intraoperative monitoring .
233660	0	parathyroid_hormone	10,29	prolactin	40,49	parathyroid hormone	prolactin	5741	5617	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on plasma prolactin in man .
19861512	0	parathyroid_hormone	22,41	prostate-specific_antigen	79,104	parathyroid hormone	prostate-specific antigen	5741	354	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	The relation of serum parathyroid_hormone and serum calcium to serum levels of prostate-specific_antigen : a population-based study .
1727720	0	parathyroid_hormone	46,65	protein_kinase-C	4,20	parathyroid hormone	protein kinase-C	5741	112476	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	The protein_kinase-C activation domain of the parathyroid_hormone .
11435617	0	parathyroid_hormone	12,31	pth-related_peptide	123,142	parathyroid hormone	pth-related peptide	5741	5744	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|dep|receptor receptor|amod|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
24423297	0	parathyroid_hormone	64,83	renin	22,27	parathyroid hormone	renin	5741	5972	Gene	Gene	concentrations|compound|START_ENTITY associated|nmod|concentrations associated|nsubjpass|aldosterone aldosterone|nmod|ratio ratio|compound|END_ENTITY	A high aldosterone to renin ratio is associated with high serum parathyroid_hormone concentrations in the general population .
24979301	0	parathyroid_hormone	60,79	renin	101,106	parathyroid hormone	renin	24694(Tax:10116)	24715(Tax:10116)	Gene	Gene	increase|amod|START_ENTITY increase|nmod|END_ENTITY	High phosphate diet increases arterial blood pressure via a parathyroid_hormone mediated increase of renin .
426073	0	parathyroid_hormone	10,29	renin	40,45	parathyroid hormone	renin	280903(Tax:9913)	280909(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|compound|END_ENTITY	Effect of parathyroid_hormone on plasma renin activity and sodium excretion .
6342000	0	parathyroid_hormone	10,29	renin	33,38	parathyroid hormone	renin	280903(Tax:9913)	280909(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of parathyroid_hormone on renin secretion .
8382128	0	parathyroid_hormone	22,41	renin	45,50	parathyroid hormone	renin	24694(Tax:10116)	24715(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Stimulatory action of parathyroid_hormone on renin secretion in vitro : a study using isolated rat kidney , isolated rabbit glomeruli and superfused dispersed rat juxtaglomerular cells .
3993434	0	parathyroid_hormone	23,42	secretin	11,19	parathyroid hormone	secretin	5741	6343	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of secretin on parathyroid_hormone and calcium in normal subjects , patients with hyperparathyroidism and patients with gastrinoma .
105871	0	parathyroid_hormone	26,45	somatostatin	10,22	parathyroid hormone	somatostatin	5741	6750	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of somatostatin on parathyroid_hormone and calcitonin secretion .
6109693	0	parathyroid_hormone	45,64	somatostatin	18,30	parathyroid hormone	somatostatin	280903(Tax:9913)	280932(Tax:9913)	Gene	Gene	secretion|amod|START_ENTITY inhibiting|dobj|secretion Mode|acl|inhibiting Mode|nmod|END_ENTITY	Mode of action of somatostatin in inhibiting parathyroid_hormone secretion .
6126979	0	parathyroid_hormone	27,46	somatostatin	11,23	parathyroid hormone	somatostatin	280903(Tax:9913)	280932(Tax:9913)	Gene	Gene	levels|amod|START_ENTITY Effects|nmod|levels Effects|nmod|END_ENTITY	Effects of somatostatin on parathyroid_hormone levels and on responses of parathyroid_hormone to beta-adrenergic agonists and hypocalcaemia .
2055117	0	parathyroid_hormone-like_peptide	22,54	PTHLH	61,66	parathyroid hormone-like peptide	PTHLH	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the rat parathyroid_hormone-like_peptide gene -LRB- PTHLH -RRB- to chromosome 4 : evidence for conserved synteny between human chromosome 12 , mouse chromosome 6 , and rat chromosome 4 .
1354597	0	parathyroid_hormone-like_peptide	22,54	Pthlh	61,66	parathyroid hormone-like peptide	Pthlh	19227(Tax:10090)	19227(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of mouse parathyroid_hormone-like_peptide gene -LRB- Pthlh -RRB- to distal chromosome 6 using interspecific backcross mice and in situ hybridization .
1280327	0	parathyroid_hormone-related_peptide	14,49	PTHrP	51,56	parathyroid hormone-related peptide	PTHrP	5744	5744	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of parathyroid_hormone-related_peptide -LRB- PTHrP -RRB- gene transcription : cell - and tissue-specific promoter utilization mediated by multiple positive and negative cis-acting DNA elements .
9274527	0	parathyroid_hormone-related_peptide	14,49	PTHrP	51,56	parathyroid hormone-related peptide	PTHrP	5744	5744	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of parathyroid_hormone-related_peptide -LRB- PTHrP -RRB- in gastric_tumours .
25970319	0	parathyroid_hormone-related_peptide	56,91	TRPV1	116,121	parathyroid hormone-related peptide	TRPV1	19227(Tax:10090)	193034(Tax:10090)	Gene	Gene	START_ENTITY|nmod|upregulation upregulation|nmod|END_ENTITY	Induction of thermal and mechanical hypersensitivity by parathyroid_hormone-related_peptide through upregulation of TRPV1 function and trafficking .
20951345	0	parathyroid_hormone-related_peptide	44,79	Zfp521	0,6	parathyroid hormone-related peptide	Zfp521	19227(Tax:10090)	225207(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Zfp521 is a target gene and key effector of parathyroid_hormone-related_peptide signaling in growth plate chondrocytes .
17967876	0	parathyroid_hormone-related_peptide	78,113	extracellular_signal-regulated_kinase	125,162	parathyroid hormone-related peptide	extracellular signal-regulated kinase	19227(Tax:10090)	26413(Tax:10090)	Gene	Gene	suppresses|nsubj|START_ENTITY suppresses|dobj|activation activation|amod|END_ENTITY	A-raf_and_B-raf are dispensable for normal endochondral bone development , and parathyroid_hormone-related_peptide suppresses extracellular_signal-regulated_kinase activation in hypertrophic chondrocytes .
15879577	0	parathyroid_hormone-related_peptide_receptor_type_1	49,100	PTHR1	102,107	parathyroid hormone-related peptide receptor type 1	PTHR1	5745	5745	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Parathyroid_hormone-related_peptide -LRB- hPTHrP -RRB- and parathyroid_hormone-related_peptide_receptor_type_1 -LRB- PTHR1 -RRB- expression in human thymus .
8420973	0	parathyroid_hormone-related_protein	25,60	Angiotensin_II	0,14	parathyroid hormone-related protein	Angiotensin II	24695(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates parathyroid_hormone-related_protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms .
12850290	0	parathyroid_hormone-related_protein	16,51	Ets-1	0,5	parathyroid hormone-related protein	Ets-1	5744	2113	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Ets-1 activates parathyroid_hormone-related_protein gene expression in tumorigenic breast epithelial cells .
11813867	0	parathyroid_hormone-related_protein	14,49	PTHrP	51,56	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in parathyroid tissue under normal and pathological conditions .
11940209	0	parathyroid_hormone-related_protein	14,49	PTHrP	51,56	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in multiple_myeloma .
12243970	0	parathyroid_hormone-related_protein	17,52	PTHrP	54,59	parathyroid hormone-related protein	PTHrP	19227(Tax:10090)	19227(Tax:10090)	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	The influence of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- on tooth-germ development and osteoclastogenesis in alveolar bone of PTHrP-knock out and wild-type mice in vitro .
14518259	0	parathyroid_hormone-related_protein	119,154	PTHrP	156,161	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Detection of disseminated carcinoma cells in bone marrow and peripheral blood in primary breast_cancer with RT/PCR of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- -RSB- .
1544706	0	parathyroid_hormone-related_protein	34,69	PTHrP	71,76	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Immunohistochemical evaluation of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in the uterine cervix .
16462110	0	parathyroid_hormone-related_protein	14,49	PTHrP	51,56	parathyroid hormone-related protein	PTHrP	286767(Tax:9913)	286767(Tax:9913)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- mRNA in mammary gland of periparturient cows .
16704084	0	parathyroid_hormone-related_protein	21,56	PTHrP	58,63	parathyroid hormone-related protein	PTHrP	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Seasonal rhythms of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- expression in growing rats after functional mandibular protrusion -RSB- .
19519497	0	parathyroid_hormone-related_protein	12,47	PTHrP	49,54	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in the pathophysiology of diabetes_mellitus .
25867375	0	parathyroid_hormone-related_protein	69,104	PTHrP	111,116	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification , molecular characterization , and tissue expression of parathyroid_hormone-related_protein gene -LRB- PTHrP -RRB- from water_buffalo -LRB- Bubalus_bubalis -RRB- .
7799315	0	parathyroid_hormone-related_protein	10,45	PTHrP	47,52	parathyroid hormone-related protein	PTHrP	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- on the contractility of the myometrium and localization of PTHrP in the uterus of pregnant rats .
7824450	0	parathyroid_hormone-related_protein	36,71	PTHrP	73,78	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in human term placenta and membranes .
9162079	0	parathyroid_hormone-related_protein	33,68	PTHrP	70,75	parathyroid hormone-related protein	PTHrP	24695(Tax:10116)	24695(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Activity-dependent expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- in rat cerebellar granule neurons .
9397964	0	parathyroid_hormone-related_protein	28,63	PTHrP	65,70	parathyroid hormone-related protein	PTHrP	5744	5744	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dexamethasone regulation of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- expression in a squamous cancer cell line .
11590145	0	parathyroid_hormone-related_protein	42,77	Transforming_growth_factor_beta	0,31	parathyroid hormone-related protein	Transforming growth factor beta	5744	7040	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor_beta regulates parathyroid_hormone-related_protein expression in MDA-MB-231_breast_cancer cells through a novel Smad/Ets synergism .
8472867	0	parathyroid_hormone-related_protein	47,82	Transforming_growth_factor_beta	0,31	parathyroid hormone-related protein	Transforming growth factor beta	5744	7040	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Transforming_growth_factor_beta stimulation of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- : a paracrine regulator ?
1310016	0	parathyroid_hormone-related_protein	67,102	Tumor_necrosis_factor_alpha	0,27	parathyroid hormone-related protein	Tumor necrosis factor alpha	5744	7124	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha inhibits the stimulatory effect of the parathyroid_hormone-related_protein on cyclic_AMP formation in osteoblast-like cells via protein kinase C + .
14966569	0	parathyroid_hormone-related_protein	53,88	calcium-sensing_receptor	4,28	parathyroid hormone-related protein	calcium-sensing receptor	5744	846	Gene	Gene	production|amod|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The calcium-sensing_receptor regulates mammary gland parathyroid_hormone-related_protein production and calcium transport .
17645771	0	parathyroid_hormone-related_protein	74,109	cyclooxygenase-2	15,31	parathyroid hormone-related protein	cyclooxygenase-2	19227(Tax:10090)	19225(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid_hormone-related_protein in colon 26 carcinoma .
14675140	0	parathyroid_hormone-related_protein	14,49	osteoprotegerin	206,221	parathyroid hormone-related protein	osteoprotegerin	5744	4982	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- , osteoclast_differentiation_factor -LRB- ODF -RRB- / receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- and osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- in ameloblastomas .
11911944	0	parathyroid_hormone-related_protein	27,62	transforming_growth_factor-beta1	76,108	parathyroid hormone-related protein	transforming growth factor-beta1	5744	7040	Gene	Gene	stability|nmod|START_ENTITY regulated|nsubj|stability regulated|advcl|END_ENTITY	Messenger RNA stability of parathyroid_hormone-related_protein regulated by transforming_growth_factor-beta1 .
14968437	0	parathyroid_hormone-related_protein	47,82	transforming_growth_factor-beta1	11,43	parathyroid hormone-related protein	transforming growth factor-beta1	5744	7040	Gene	Gene	mRNA|amod|START_ENTITY END_ENTITY|nmod|mRNA	Effects of transforming_growth_factor-beta1 on parathyroid_hormone-related_protein mRNA expression and protein secretion in canine prostate epithelial , stromal , and carcinoma cells .
9741834	0	parathyroid_hormone-related_protein	46,81	transforming_growth_factor-beta1	10,42	parathyroid hormone-related protein	transforming growth factor-beta1	5744	7040	Gene	Gene	secretion|amod|START_ENTITY END_ENTITY|nmod|secretion	Effect of transforming_growth_factor-beta1 on parathyroid_hormone-related_protein secretion and mRNA expression by normal human keratinocytes in vitro .
9870872	0	parathyroid_hormone-related_protein	86,121	transforming_growth_factor_beta	162,193	parathyroid hormone-related protein	transforming growth factor beta	5744	7040	Gene	Gene	isoform|amod|START_ENTITY induced|nsubjpass|isoform induced|nmod|END_ENTITY	Parathyroid_hormone-related_proteins is abundant in osteoarthritic cartilage , and the parathyroid_hormone-related_protein 1-173 isoform is selectively induced by transforming_growth_factor_beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate .
23780896	0	parathyroid_hormone-related_protein	25,60	vascular_endothelial_growth_factor	109,143	parathyroid hormone-related protein	vascular endothelial growth factor	5744	7422	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|expression expression|amod|END_ENTITY	Paraneoplastic hormones : parathyroid_hormone-related_protein -LRB- PTHrP -RRB- and erythropoietin -LRB- EPO -RRB- are related to vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in clear_cell_renal_cell_carcinoma .
25462297	0	parathyroid_hormone_2_receptor	60,90	PTH2R	92,97	parathyroid hormone 2 receptor	PTH2R	5746	5746	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	PFOA and PFOS are associated with reduced expression of the parathyroid_hormone_2_receptor -LRB- PTH2R -RRB- gene in women .
22554804	0	parathyroid_hormone_receptor	71,99	Vav2	39,43	parathyroid hormone receptor	Vav2	5745	7410	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	The guanine_nucleotide exchange factor Vav2 is a negative regulator of parathyroid_hormone_receptor / Gq signaling .
10853826	0	parathyroid_hormone_related_peptide	43,78	Snail	0,5	parathyroid hormone related peptide	Snail	19227(Tax:10090)	20613(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Snail is an immediate early target gene of parathyroid_hormone_related_peptide signaling in parietal_endoderm formation .
15249318	0	parathyroid_hormone_related_protein	22,57	PTHrP	59,64	parathyroid hormone related protein	PTHrP	100009357(Tax:9986)	100009357(Tax:9986)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Sequential changes of parathyroid_hormone_related_protein -LRB- PTHrP -RRB- in articular cartilage during progression of inflammatory and degenerative_arthritis .
2051695	0	parathyroid_hormone_related_protein	30,65	PTHrP	67,72	parathyroid hormone related protein	PTHrP	5744	5744	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Immunohistochemical study of parathyroid_hormone_related_protein -LRB- PTHrP -RRB- in renal_cell_carcinoma -RSB- .
9693142	0	paraxial_protocadherin	10,32	spadetail	59,68	paraxial protocadherin	spadetail	30456(Tax:7955)	30264(Tax:7955)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Zebrafish paraxial_protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm .
20194754	0	parkin	11,17	PINK1	27,32	parkin	PINK1	40336(Tax:7227)	31607(Tax:7227)	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin .
15925106	0	parkin_co-regulated_gene	20,44	PACRG	46,51	parkin co-regulated gene	PACRG	135138	135138	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Genetic analysis of parkin_co-regulated_gene -LRB- PACRG -RRB- in patients with early-onset parkinsonism .
24564321	0	part_1	18,24	Hsp90	0,5	part 1	Hsp90	25859	3320	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Hsp90 inhibitors , part_1 : definition of 3-D QSAutogrid/R models as a tool for virtual screening .
22069106	0	part_1	44,50	VEGF	36,40	part 1	VEGF	25859	7422	Gene	Gene	Vascular_endothelial_growth_factor|dep|START_ENTITY Vascular_endothelial_growth_factor|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - part_1 : in physiology and pathophysiology .
24155988	0	part_1	43,49	filaggrin	63,72	part 1	filaggrin	25859	2312	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Atopic_dermatitis and the stratum corneum : part_1 : the role of filaggrin in the stratum corneum barrier and atopic skin .
25091320	0	parvalbumin	60,71	GAD67	40,45	parvalbumin	GAD67	697272(Tax:9544)	613030(Tax:9544)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regional and age-related differences in GAD67 expression of parvalbumin - and calbindin-expressing neurons in the rhesus_macaque auditory midbrain and brainstem .
19787094	0	parvulin	48,56	par14	32,37	parvulin	par14	5303	5303	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Small family with key contacts : par14 and par17 parvulin proteins , relatives of pin1 , now emerge in biomedical research .
11784037	0	pasilla	0,7	Nova-1	47,53	pasilla	Nova-1	44258(Tax:7227)	4857	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	pasilla , the Drosophila homologue of the human Nova-1 and Nova-2 proteins , is required for normal secretion in the salivary gland .
20803499	0	patatin-like_phospholipase_3	24,52	PNPLA3	59,65	patatin-like phospholipase 3	PNPLA3	80339	80339	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common variant in the patatin-like_phospholipase_3 gene -LRB- PNPLA3 -RRB- is associated with fatty_liver_disease in obese children and adolescents .
23734760	0	patatin-like_phospholipase_domain-containing_protein-3	25,79	PNPLA-3	81,88	patatin-like phospholipase domain-containing protein-3	PNPLA-3	80339	80339	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the patatin-like_phospholipase_domain-containing_protein-3 -LRB- PNPLA-3 -RRB- gene in Asian Indians with nonalcoholic_fatty_liver_disease .
10200051	0	patched	76,83	PTCH	85,89	patched	PTCH	5727	5727	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gorlin syndrome : identification of 4 novel germ-line mutations of the human patched -LRB- PTCH -RRB- gene .
10554356	0	patched	15,22	PTCH	24,28	patched	PTCH	5727	5727	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Involvement of patched -LRB- PTCH -RRB- gene in Gorlin_syndrome and related disorders : three family cases .
9192803	0	patched	6,13	PTCH	15,19	patched	PTCH	5727	5727	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Human patched -LRB- PTCH -RRB- mRNA is overexpressed consistently in tumor cells of both familial_and_sporadic_basal_cell_carcinoma .
17621626	0	paternally_expressed_gene_10	22,50	PEG10	52,57	paternally expressed gene 10	PEG10	23089	23089	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the paternally_expressed_gene_10 -LRB- PEG10 -RRB- from the imprinted locus on chromosome 7q21 in high-risk B-cell_chronic_lymphocytic_leukemia .
9813166	0	pax-8	15,20	Ref-1	0,5	pax-8	Ref-1	7849	328	Gene	Gene	activity|amod|START_ENTITY controls|dobj|activity controls|nsubj|END_ENTITY	Ref-1 controls pax-8 DNA-binding activity .
20525696	0	paxillin	78,86	ARNO	12,16	paxillin	ARNO	19303(Tax:10090)	19158(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY END_ENTITY|nmod|interaction	Cytohesin-2 / ARNO , through its interaction with focal adhesion adaptor protein paxillin , regulates preadipocyte migration via the downstream activation of Arf6 .
7525608	0	paxillin	54,62	Beta_2	0,6	paxillin	Beta 2	5829	10242	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Beta_2 integrin-dependent tyrosine phosphorylation of paxillin in human neutrophils treated with tumor necrosis factor .
11035932	0	paxillin	47,55	CEACAM1	23,30	paxillin	CEACAM1	5829	634	Gene	Gene	associates|nmod|START_ENTITY associates|compound|END_ENTITY	Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells .
10753946	0	paxillin	19,27	ERK	36,39	paxillin	ERK	19303(Tax:10090)	26413(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4_thymoma cells .
24344012	0	paxillin	26,34	EZH2	20,24	paxillin	EZH2	5829	2146	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Prognostic value of EZH2 , paxillin expression and DNA ploidy of breast_adenocarcinoma : correlation to pathologic predictors .
16537926	0	paxillin	99,107	Glycogen_synthase_kinase_3	0,26	paxillin	Glycogen synthase kinase 3	19303(Tax:10090)	56637(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Glycogen_synthase_kinase_3 - and extracellular_signal-regulated_kinase-dependent phosphorylation of paxillin regulates cytoskeletal rearrangement .
10092676	0	paxillin	9,17	Hic-5	0,5	paxillin	Hic-5	5829	7041	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Hic-5 , a paxillin homologue , binds to the protein-tyrosine_phosphatase_PEST -LRB- PTP-PEST -RRB- through its LIM 3 domain .
14718530	0	paxillin	21,29	Hsp72	0,5	paxillin	Hsp72	5829	3303	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Hsp72 interacts with paxillin and facilitates the reassembly of focal adhesions during recovery from ATP depletion .
15163899	0	paxillin	42,50	IL-4	14,18	paxillin	IL-4	517456(Tax:9913)	280824(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells .
22700880	0	paxillin	15,23	MLK3	0,4	paxillin	MLK3	19303(Tax:10090)	26403(Tax:10090)	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	MLK3 regulates paxillin phosphorylation in chemokine-mediated breast_cancer cell migration and invasion to drive metastasis .
9366396	0	paxillin	117,125	Proline-rich_tyrosine_kinase-2	0,30	paxillin	Proline-rich tyrosine kinase-2	5829	2185	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Proline-rich_tyrosine_kinase-2 activation by beta_1_integrin fibronectin receptor cross-linking and association with paxillin in human natural killer cells .
24795566	0	paxillin	97,105	SIRPa	61,66	paxillin	SIRPa	5829	140885	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Phagocytic receptors activate and immune inhibitory receptor SIRPa inhibits phagocytosis through paxillin and cofilin .
7525604	0	paxillin	116,124	beta_2	52,58	paxillin	beta 2	5829	10242	Gene	Gene	phosphorylation|nmod|START_ENTITY required|nmod|phosphorylation required|nsubjpass|receptor receptor|appos|Mac-1 Mac-1|dep|END_ENTITY	Complement receptor 3 -LRB- CR3 , Mac-1 , integrin alpha M beta_2 , CD11b/CD18 -RRB- is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils .
12198769	0	paxillin	76,84	phosphatase-2A	8,22	paxillin	phosphatase-2A	5829	5524	Gene	Gene	phosphorylation|nmod|START_ENTITY modulates|dobj|phosphorylation modulates|nsubj|END_ENTITY	Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis_lung_carcinoma tumor variants .
21597718	0	pcna	85,89	p53	33,36	pcna	p53	5111	7157	Gene	Gene	detection|appos|START_ENTITY detection|nmod|protein protein|compound|END_ENTITY	Immunohistochemical detection of p53 protein and proliferating_cell_nuclear_antigen -LRB- pcna -RRB- in salivary-gland_tumors .
22111549	0	pdcd4	84,89	programmed_cell_death_protein_4	51,82	pdcd4	programmed cell death protein 4	27250	27250	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Promoter cloning and characterization of the human programmed_cell_death_protein_4 -LRB- pdcd4 -RRB- gene : evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators .
12128230	0	pdgfr-alpha	47,58	Platelet-derived_growth_factor_receptor_alpha	0,45	pdgfr-alpha	Platelet-derived growth factor receptor alpha	386856(Tax:7955)	100148428(Tax:7955)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Platelet-derived_growth_factor_receptor_alpha -LRB- pdgfr-alpha -RRB- gene in zebrafish embryonic development .
9701587	0	pds1	35,39	p-hydroxyphenylpyruvate_dioxygenase	72,107	pds1	p-hydroxyphenylpyruvate dioxygenase	837168(Tax:3702)	837168(Tax:3702)	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	Complementation of the Arabidopsis pds1 mutation with the gene encoding p-hydroxyphenylpyruvate_dioxygenase .
18465999	0	ped	53,56	preimplantation-embryo-development	17,51	ped	preimplantation-embryo-development	110340(Tax:10090)	110340(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Influence of the preimplantation-embryo-development -LRB- ped -RRB- gene on mouse blastocyst differentiation .
12438745	0	pelota	6,12	Pelo	19,23	pelota	Pelo	34286(Tax:7227)	105083(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mouse pelota gene -LRB- Pelo -RRB- : cDNA cloning , genomic structure , and chromosomal localization .
10560468	0	pen	23,26	Insulin	0,7	pen	Insulin	340348	3630	Gene	Gene	devices|compound|START_ENTITY using|dobj|devices delivery|acl|using delivery|compound|END_ENTITY	Insulin delivery using pen devices .
17954427	0	pen	8,11	Insulin	0,7	pen	Insulin	340348	3630	Gene	Gene	devices|compound|START_ENTITY devices|amod|END_ENTITY	Insulin pen injection devices for management of patients with type 2 diabetes : considerations based on an endocrinologist 's practical experience in the United States .
19075079	0	pen	71,74	Insulin	0,7	pen	Insulin	340348	3630	Gene	Gene	therapy|nmod|START_ENTITY addressing|nmod|therapy devices|dep|addressing devices|compound|END_ENTITY	Insulin devices : addressing barriers to insulin therapy with the ideal pen .
19885358	0	pen	49,52	Insulin	0,7	pen	Insulin	340348	3630	Gene	Gene	wins|nsubj|START_ENTITY pen-the|parataxis|wins pen-the|nsubj|END_ENTITY	Insulin pen-the `` iPod '' for insulin delivery -LRB- why pen wins over syringe -RRB- .
20515313	0	pen	8,11	Insulin	0,7	pen	Insulin	340348	3630	Gene	Gene	use|compound|START_ENTITY use|compound|END_ENTITY	Insulin pen use for type 2 diabetes -- a clinical perspective .
20615098	0	pen	37,40	Insulin	0,7	pen	Insulin	340348	3630	Gene	Gene	length|compound|START_ENTITY leakage|nmod|length leakage|nsubj|END_ENTITY	Insulin leakage value in relation to pen needle length and administered dose after subcutaneous injection .
23790553	0	pen	8,11	Insulin	0,7	pen	Insulin	340348	3630	Gene	Gene	needles|compound|START_ENTITY needles|amod|END_ENTITY	Insulin pen needles : effects of extra-thin wall needle technology on preference , confidence , and other patient ratings .
24748824	0	pen	136,139	growth_hormone	161,175	pen	growth hormone	340348	2688	Gene	Gene	START_ENTITY|nmod|treatment treatment|nmod|deficiency deficiency|amod|END_ENTITY	Results from an international multicenter trial evaluating the ease-of-use of and preference for a newly developed disposable injection pen for the treatment of growth_hormone deficiency in treatment-na ve children and adults .
8563072	0	pen	38,41	growth_hormone	46,60	pen	growth hormone	340348	2688	Gene	Gene	START_ENTITY|nmod|treatment treatment|amod|END_ENTITY	Patient evaluation of a new injection pen for growth_hormone treatment in children and adults .
11433217	0	pen	9,12	insulin	41,48	pen	insulin	340348	3630	Gene	Gene	Syringe|appos|START_ENTITY Syringe|dep|evolution evolution|nmod|therapy therapy|compound|END_ENTITY	Syringe , pen , inhaler - the evolution of insulin therapy .
14693308	0	pen	151,154	insulin	189,196	pen	insulin	340348	3630	Gene	Gene	trial|nmod|START_ENTITY trial|nmod|injection injection|compound|END_ENTITY	A multicenter , randomized , open-label , comparative , two-period crossover trial of preference , efficacy , and safety profiles of a prefilled , disposable pen and conventional vial/syringe for insulin injection in patients with type 1 or 2 diabetes_mellitus .
15154947	0	pen	58,61	insulin	47,54	pen	insulin	340348	3630	Gene	Gene	injectors|compound|START_ENTITY assessment|nmod|injectors assessment|nmod|END_ENTITY	An assessment of the adequacy of suspension of insulin in pen injectors .
1642530	0	pen	90,93	insulin	12,19	pen	insulin	340348	3630	Gene	Gene	stabilization|nmod|START_ENTITY administration|dep|stabilization administration|compound|END_ENTITY	Independent insulin administration by the hemiplegic patient : stabilization of an insulin pen with a new device .
1751505	0	pen	11,14	insulin	45,52	pen	insulin	340348	3630	Gene	Gene	system|compound|START_ENTITY Use|nmod|system Use|nmod|therapy therapy|compound|END_ENTITY	Use of the pen delivery system for intensive insulin therapy in college-age students with type_I_diabetes .
19075079	0	pen	71,74	insulin	40,47	pen	insulin	340348	3630	Gene	Gene	therapy|nmod|START_ENTITY therapy|compound|END_ENTITY	Insulin devices : addressing barriers to insulin therapy with the ideal pen .
19580357	0	pen	28,31	insulin	20,27	pen	insulin	340348	3630	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	The prescription of insulin pen devices versus syringes for older people with diabetes .
19885358	0	pen	49,52	insulin	27,34	pen	insulin	340348	3630	Gene	Gene	wins|nsubj|START_ENTITY pen-the|parataxis|wins pen-the|xcomp|iPod iPod|dep|delivery delivery|compound|END_ENTITY	Insulin pen-the `` iPod '' for insulin delivery -LRB- why pen wins over syringe -RRB- .
20105044	0	pen	27,30	insulin	9,16	pen	insulin	340348	3630	Gene	Gene	device|compound|START_ENTITY device|compound|END_ENTITY	The best insulin injection pen device for caregivers : results of injection trials using five insulin injection devices .
20105044	0	pen	27,30	insulin	93,100	pen	insulin	340348	3630	Gene	Gene	device|compound|START_ENTITY device|dep|results results|nmod|trials trials|acl|using using|dobj|devices devices|compound|END_ENTITY	The best insulin injection pen device for caregivers : results of injection trials using five insulin injection devices .
20513316	0	pen	29,32	insulin	21,28	pen	insulin	340348	3630	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	Practical aspects of insulin pen devices .
22879787	0	pen	20,23	insulin	12,19	pen	insulin	340348	3630	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	A review of insulin pen devices and use in the elderly diabetic population .
22920819	0	pen	71,74	insulin	53,60	pen	insulin	340348	3630	Gene	Gene	devices|compound|START_ENTITY devices|compound|END_ENTITY	Analysis of comparison of patient preference for two insulin injection pen devices in relation to patient dexterity skills .
8306595	0	pen	42,45	insulin	10,17	pen	insulin	340348	3630	Gene	Gene	delivered|nmod|START_ENTITY delivered|nsubj|END_ENTITY	Pre-mixed insulin delivered by disposable pen in the management of children with diabetes .
8529495	0	pen	56,59	insulin	48,55	pen	insulin	340348	3630	Gene	Gene	START_ENTITY|nsubj|acceptability acceptability|nmod|END_ENTITY	Safety , efficacy , acceptability of a pre-filled insulin pen in diabetic patients over 60 years old .
24429827	0	pendrin	15,22	Sgk1	0,4	pendrin	Sgk1	23985(Tax:10090)	20393(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Sgk1 sensitive pendrin expression in murine platelets .
9358038	0	penicillin-binding_protein_1A	54,83	ponA	16,20	penicillin-binding protein 1A	ponA	881163(Tax:208964)	881163(Tax:208964)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Sequence of the ponA gene and characterization of the penicillin-binding_protein_1A of Pseudomonas_aeruginosa_PAO1 .
21920889	0	pentraxin-3	69,80	COPD	0,4	pentraxin-3	COPD	5806	260431	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubjpass|END_ENTITY	COPD is associated with reduced pulmonary interstitial expression of pentraxin-3 .
16647920	0	pentraxin_3	37,48	PTX3	50,54	pentraxin 3	PTX3	5806	5806	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated maternal levels of the long pentraxin_3 -LRB- PTX3 -RRB- in preeclampsia and intrauterine_growth_restriction .
18220316	0	pentraxin_3	14,25	PTX3	27,31	pentraxin 3	PTX3	5806	5806	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pentraxin_3 -LRB- PTX3 -RRB- in human atherosclerotic_lesions .
19327124	0	pentraxin_3	38,49	PTX3	51,55	pentraxin 3	PTX3	5806	5806	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Determination of physiological plasma pentraxin_3 -LRB- PTX3 -RRB- levels in healthy populations .
23285251	0	pentraxin_3	13,24	PTX3	26,30	pentraxin 3	PTX3	5806	5806	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Influence of pentraxin_3 -LRB- PTX3 -RRB- genetic variants on myocardial_infarction risk and PTX3 plasma levels .
24652286	0	pentraxin_3	27,38	PTX3	40,44	pentraxin 3	PTX3	5806	5806	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Constitutive expression of pentraxin_3 -LRB- PTX3 -RRB- protein by human amniotic membrane cells leads to formation of the heavy chain -LRB- HC -RRB- - hyaluronan -LRB- HA -RRB- - PTX3 complex .
22447522	0	pentraxin_3	30,41	Serum_amyloid_A	0,15	pentraxin 3	Serum amyloid A	5806	6287	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Serum_amyloid_A -LRB- SAA -RRB- induces pentraxin_3 -LRB- PTX3 -RRB- production in rheumatoid_synoviocytes .
23379644	0	pentraxin_3	16,27	insulin	33,40	pentraxin 3	insulin	5806	3630	Gene	Gene	START_ENTITY|nmod|sensitivity sensitivity|compound|END_ENTITY	Relationship of pentraxin_3 with insulin sensitivity in gestational diabetes .
22796679	0	pepN	110,114	aminopeptidase	95,109	pepN	aminopeptidase	290	10404	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Development of a primer system to study abundance and diversity of the gene coding for alanine aminopeptidase pepN gene in Gram-negative soil bacteria .
8238515	0	pepsinogen	68,78	gastrin	19,26	pepsinogen	gastrin	100328625(Tax:9986)	100345451(Tax:9986)	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Partial agonism by gastrin for a cholecystokinin receptor mediating pepsinogen secretion .
2612209	0	pepsinogen_C	20,32	PGC	34,37	pepsinogen C	PGC	5225	5225	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Assignment of human pepsinogen_C -LRB- PGC -RRB- gene to chromosome 6 .
7720628	0	peptide-23	23,33	reg	95,98	peptide-23	reg	24618(Tax:10116)	24714(Tax:10116)	Gene	Gene	changes|nmod|START_ENTITY END_ENTITY|nsubj|changes	Age-related changes in peptide-23 / pancreatitis-associated protein and pancreatic_stone_protein / reg gene expression in the rat and regulation by growth_hormone-releasing_hormone .
18022952	0	peptide_YY	30,40	PYY	42,45	peptide YY	PYY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of brainstem peptide_YY -LRB- PYY -RRB- neurons .
2704235	0	peptide_YY	23,33	PYY	35,38	peptide YY	PYY	607156(Tax:9615)	607156(Tax:9615)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Independent release of peptide_YY -LRB- PYY -RRB- into the circulation and ileal lumen of the awake dog .
3557189	0	peptide_YY	11,21	PYY	23,26	peptide YY	PYY	5697	5697	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of peptide_YY -LRB- PYY -RRB- on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers .
6956876	0	peptide_YY	16,26	PYY	28,31	peptide YY	PYY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of peptide_YY -LRB- PYY -RRB- in gastrointestinal endocrine cells and effects on intestinal blood flow and motility .
7694325	0	peptide_YY	31,41	PYY	43,46	peptide YY	PYY	100348019(Tax:9986)	100348019(Tax:9986)	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Cyclic_AMP-mediated release of peptide_YY -LRB- PYY -RRB- from the isolated perfused rabbit distal colon .
7782089	0	peptide_YY	30,40	PYY	47,50	peptide YY	PYY	5697	5697	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Gene duplication of the human peptide_YY gene -LRB- PYY -RRB- generated the pancreatic_polypeptide gene -LRB- PPY -RRB- on chromosome 17q21 .1 .
8097274	0	peptide_YY	91,101	PYY	103,106	peptide YY	PYY	5697	5697	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Proteolytic processing by dipeptidyl_aminopeptidase_IV generates receptor selectivity for peptide_YY -LRB- PYY -RRB- -RSB- .
8559783	0	peptide_YY	10,20	PYY	22,25	peptide YY	PYY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of peptide_YY -LRB- PYY -RRB- on food-associated conflict .
9874177	0	peptide_YY	52,62	Y5_receptor	96,107	peptide YY	Y5 receptor	287730(Tax:10116)	25340(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Pharmacological profile of the rat intestinal crypt peptide_YY receptor vs. the recombinant rat Y5_receptor .
7813861	0	peptide_YY	14,24	glucagon-like_peptide_1	39,62	peptide YY	glucagon-like peptide 1	287730(Tax:10116)	24952(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Secretion of peptide_YY and truncated glucagon-like_peptide_1 by isolated intestinal cells in rats -RSB- .
19273273	0	peptide_YY	2,12	renin	32,37	peptide YY	renin	5697	5972	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|compound|END_ENTITY	A peptide_YY inhibits the human renin activity in a pH dependent manner .
1307917	0	peptide_YY	21,31	secretin	74,82	peptide YY	secretin	607156(Tax:9615)	483407(Tax:9615)	Gene	Gene	action|nmod|START_ENTITY independent|nsubj|action independent|nmod|END_ENTITY	Inhibitory action of peptide_YY on pancreatic secretion is independent of secretin .
16253763	0	peptide_transporter_1	20,41	PEPT1	43,48	peptide transporter 1	PEPT1	6564	6564	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of human peptide_transporter_1 -LRB- PEPT1 -RRB- in gastric_cancer cells by anticancer drugs .
23234698	0	peptide_transporter_1	33,54	PepT1	56,61	peptide transporter 1	PepT1	397624(Tax:9823)	397624(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ontogeny of dipeptide uptake and peptide_transporter_1 -LRB- PepT1 -RRB- expression along the gastrointestinal tract in the neonatal Yucatan miniature pig .
17689997	0	peptidoglycan_recognition_protein	6,39	PGRP	41,45	peptidoglycan recognition protein	PGRP	100862794	100862794	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Three peptidoglycan_recognition_protein -LRB- PGRP -RRB- genes encoding potential amidase from eri-silkworm , Samia_cynthia_ricini .
23416224	0	peptidoglycan_recognition_protein	44,77	PGRP	79,83	peptidoglycan recognition protein	PGRP	105331238	105331238	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The first evidence of positive selection in peptidoglycan_recognition_protein -LRB- PGRP -RRB- genes of Crassostrea_gigas .
11872802	0	peptidoglycan_recognition_protein	18,51	Relish	62,68	peptidoglycan recognition protein	Relish	32534(Tax:7227)	41087(Tax:7227)	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	Requirement for a peptidoglycan_recognition_protein -LRB- PGRP -RRB- in Relish activation and antibacterial immune responses in Drosophila .
11742401	0	peptidoglycan_recognition_protein	77,110	Toll	11,15	peptidoglycan recognition protein	Toll	32534(Tax:7227)	43222(Tax:7227)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan_recognition_protein .
23407864	0	peptidyl-prolyl_isomerase	40,65	Pin1	35,39	peptidyl-prolyl isomerase	Pin1	51645	5300	Gene	Gene	domain|amod|START_ENTITY domain|amod|END_ENTITY	Non-catalytic participation of the Pin1 peptidyl-prolyl_isomerase domain in target binding .
16595688	0	peptidyl_prolyl_isomerase-like_protein_1	28,68	SKIP	108,112	peptidyl prolyl isomerase-like protein 1	SKIP	51645	22938	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Solution structure of human peptidyl_prolyl_isomerase-like_protein_1 and insights into its interaction with SKIP .
24298040	0	peptidylarginine_deiminase	29,55	PAD	57,60	peptidylarginine deiminase	PAD	23569	23569	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Methods for the detection of peptidylarginine_deiminase -LRB- PAD -RRB- activity and protein citrullination .
20668670	0	peptidylarginine_deiminase_2	19,47	PAD2	49,53	peptidylarginine deiminase 2	PAD2	11240	11240	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential role for peptidylarginine_deiminase_2 -LRB- PAD2 -RRB- in citrullination of canine mammary epithelial cell histones .
22126893	0	peptidylarginine_deiminase_4	31,59	PAD4	61,65	peptidylarginine deiminase 4	PAD4	23569	23569	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization and expression of peptidylarginine_deiminase_4 -LRB- PAD4 -RRB- in mammalian oocytes and preimplantation embryos .
17851584	0	peptidylarginine_deiminase_type_I	71,104	MZF1	17,21	peptidylarginine deiminase type I	MZF1	29943	7593	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene roles|nmod|regulation roles|nmod|END_ENTITY	Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine_deiminase_type_I gene -LRB- PADI1 -RRB- in human keratinocytes .
17851584	0	peptidylarginine_deiminase_type_I	71,104	PADI1	111,116	peptidylarginine deiminase type I	PADI1	29943	29943	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine_deiminase_type_I gene -LRB- PADI1 -RRB- in human keratinocytes .
16671893	0	peptidylarginine_deiminase_type_III	71,106	PADI3	113,118	peptidylarginine deiminase type III	PADI3	51702	51702	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine_deiminase_type_III gene -LRB- PADI3 -RRB- in human keratinocytes .
17456793	0	peptidylarginine_deiminase_type_IV	18,52	PADI4	59,64	peptidylarginine deiminase type IV	PADI4	23569	23569	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Estrogen-enhanced peptidylarginine_deiminase_type_IV gene -LRB- PADI4 -RRB- expression in MCF-7 cells is mediated by estrogen receptor-alpha-promoted transfactors activator_protein-1 , nuclear factor-Y , and Sp1 .
10639739	0	peptidylglycine_alpha-amidating_monooxygenase	35,80	PAM	82,85	peptidylglycine alpha-amidating monooxygenase	PAM	25508(Tax:10116)	25508(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Characterization and regulation of peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- expression in H9c2 cardiac myoblasts .
2925636	0	peptidylglycine_alpha-amidating_monooxygenase	28,73	PAM	75,78	peptidylglycine alpha-amidating monooxygenase	PAM	25508(Tax:10116)	25508(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Developmental regulation of peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- in rat heart atrium and ventricle .
8288234	0	peptidylglycine_alpha-amidating_monooxygenase	34,79	PAM	81,84	peptidylglycine alpha-amidating monooxygenase	PAM	5066	5066	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the gene encoding peptidylglycine_alpha-amidating_monooxygenase -LRB- PAM -RRB- to human chromosome 5q14-5q21 .
11278753	0	peptidylprolyl_isomerase	18,42	FKBP52	84,90	peptidylprolyl isomerase	FKBP52	2289	2288	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Evidence that the peptidylprolyl_isomerase domain of the hsp90-binding_immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid_receptor movement to the nucleus .
11876785	0	per1	42,46	Vasoactive_intestinal_polypeptide	0,33	per1	Vasoactive intestinal polypeptide	287422(Tax:10116)	117064(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Vasoactive_intestinal_polypeptide induces per1 and per2 gene expression in the rat suprachiasmatic nucleus late at night .
21828288	0	per1	47,51	period_1	37,45	per1	period 1	5187	5187	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of the circadian rhythm gene period_1 -LRB- per1 -RRB- on psychosocial stress-induced alcohol drinking .
23850797	0	per2	37,41	angiotensin_II	10,24	per2	angiotensin II	63840(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Effect of angiotensin_II on rhythmic per2 expression in the suprachiasmatic nucleus and heart and daily rhythm of activity in Wistar_rats .
21076970	0	per2	72,76	bmal1	78,83	per2	bmal1	63840(Tax:10116)	29657(Tax:10116)	Gene	Gene	ppara|compound|START_ENTITY ppara|dep|END_ENTITY	Effect of phase delay lighting rotation schedule on daily expression of per2 , bmal1 , rev-erba , ppara , and pdk4 genes in the heart and liver of Wistar_rats .
23073290	0	perforin	47,55	PRF1	42,46	perforin	PRF1	5551	5551	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Functional impact of A91V mutation of the PRF1 perforin gene .
2095003	0	perforin	77,85	Pfp	87,90	perforin	Pfp	18646(Tax:10090)	5551	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Novel putative promoter/enhancer sequences are shared by the mouse and human perforin -LRB- Pfp -RRB- genes .
24011642	0	periaxin	45,53	CMT4F	65,70	periaxin	CMT4F	57716	57716	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	-LSB- Charcot-Marie-Tooth_disease associated with periaxin mutations -LRB- CMT4F -RRB- : Clinical , electrophysiological and genetic analysis of 24 patients -RSB- .
20471352	0	pericentrin	24,35	Cdk5rap2	0,8	pericentrin	Cdk5rap2	5116	55755	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex .
18174396	0	pericentrin	17,28	PCNT	30,34	pericentrin	PCNT	5116	5116	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the pericentrin -LRB- PCNT -RRB- gene cause primordial dwarfism .
19448849	0	pericentrin	28,39	PCNT	41,45	pericentrin	PCNT	5116	5116	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Positive association of the pericentrin -LRB- PCNT -RRB- gene with major_depressive_disorder in the Japanese population .
19937158	0	pericentrin	30,41	PCNT	43,47	pericentrin	PCNT	5116	5116	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association study between the pericentrin -LRB- PCNT -RRB- gene and schizophrenia .
22184200	0	pericentrin	24,35	PLK1	0,4	pericentrin	PLK1	5116	5347	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nummod|END_ENTITY	PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis .
16251193	0	pericentrin	12,23	membrane_type-1_matrix_metalloproteinase	55,95	pericentrin	membrane type-1 matrix metalloproteinase	5116	4323	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Centrosomal pericentrin is a direct cleavage target of membrane_type-1_matrix_metalloproteinase in humans but not in mice : potential implications for tumorigenesis .
15770500	0	perilipin	57,66	PLIN	73,77	perilipin	PLIN	5346	5346	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Intragenic linkage disequilibrium structure of the human perilipin gene -LRB- PLIN -RRB- and haplotype association with increased obesity risk in a multiethnic Asian population .
21504789	0	perilipin	69,78	receptor-interacting_protein_140	12,44	perilipin	receptor-interacting protein 140	5346	8204	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cytoplasmic receptor-interacting_protein_140 -LRB- RIP140 -RRB- interacts with perilipin to regulate lipolysis .
23936516	0	perilipin-3	16,27	TIP47	29,34	perilipin-3	TIP47	10226	10226	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Crucial role of perilipin-3 -LRB- TIP47 -RRB- in formation of lipid_droplets and PGE2 production in HL-60-derived neutrophils .
21148142	0	perilipin-5	16,27	adipose_triglyceride_lipase	41,68	perilipin-5	adipose triglyceride lipase	440503	57104	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of perilipin-5 -LRB- Plin5 -RRB- with adipose_triglyceride_lipase .
20842447	0	perilipin_2	23,34	PLIN2	36,41	perilipin 2	PLIN2	397402(Tax:9823)	397402(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	New SNP of the porcine perilipin_2 -LRB- PLIN2 -RRB- gene , association with carcass traits and expression analysis in skeletal muscle .
21393244	0	perilipin_5	59,70	ATGL	50,54	perilipin 5	ATGL	440503	57104	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Unique regulation of adipose_triglyceride_lipase -LRB- ATGL -RRB- by perilipin_5 , a lipid_droplet-associated_protein .
21393244	0	perilipin_5	59,70	adipose_triglyceride_lipase	21,48	perilipin 5	adipose triglyceride lipase	440503	57104	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Unique regulation of adipose_triglyceride_lipase -LRB- ATGL -RRB- by perilipin_5 , a lipid_droplet-associated_protein .
15917222	0	period-1	111,119	Per1	121,125	period-1	Per1	5187	5187	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 -LRB- Per1 -RRB- protein .
19414365	0	period2	17,24	Clock	0,5	period2	Clock	18627(Tax:10090)	12753(Tax:10090)	Gene	Gene	overexpression|amod|START_ENTITY mouse|dep|overexpression mouse|compound|END_ENTITY	Clock gene mouse period2 overexpression inhibits growth of human pancreatic_cancer cells and has synergistic effect with cisplatin .
15809976	0	period_1	23,31	PER1	33,37	period 1	PER1	5187	5187	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abnormal expression of period_1 -LRB- PER1 -RRB- in endometrial_carcinoma .
21828288	0	period_1	37,45	per1	47,51	period 1	per1	5187	5187	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of the circadian rhythm gene period_1 -LRB- per1 -RRB- on psychosocial stress-induced alcohol drinking .
26403971	0	period_2	62,70	clock	51,56	period 2	clock	18627(Tax:10090)	12753(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Mitomycin_C modulates the circadian oscillation of clock gene period_2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts .
26930720	0	periostin	70,79	POSTN	63,68	periostin	POSTN	10631	10631	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	p73 promotes glioblastoma cell invasion by directly activating POSTN -LRB- periostin -RRB- expression .
10965884	0	peripheral-type_benzodiazepine_receptor	64,103	PBR	105,108	peripheral-type benzodiazepine receptor	PBR	24230(Tax:10116)	24230(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The peroxisome proliferator perfluorodecanoic_acid inhibits the peripheral-type_benzodiazepine_receptor -LRB- PBR -RRB- expression and hormone-stimulated mitochondrial cholesterol transport and steroid formation in Leydig cells .
1332905	0	peripheral-type_benzodiazepine_receptor	33,72	PBR	74,77	peripheral-type benzodiazepine receptor	PBR	12257(Tax:10090)	12257(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Cell surface localization of the peripheral-type_benzodiazepine_receptor -LRB- PBR -RRB- in adrenal cortex .
15769477	0	peripheral_benzodiazepine_receptor	35,69	PBR	71,74	peripheral benzodiazepine receptor	PBR	706	706	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Nuclear location-dependent role of peripheral_benzodiazepine_receptor -LRB- PBR -RRB- in hepatic_tumoral cell lines proliferation .
16511838	0	peripheral_benzodiazepine_receptor	31,65	PBR	67,70	peripheral benzodiazepine receptor	PBR	706	706	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence that variation in the peripheral_benzodiazepine_receptor -LRB- PBR -RRB- gene influences susceptibility to panic_disorder .
18492798	0	peripheral_benzodiazepine_receptor	4,38	constitutive_androstane_receptor	136,168	peripheral benzodiazepine receptor	constitutive androstane receptor	706	9970	Gene	Gene	antagonist|nsubj|START_ENTITY antagonist|nmod|END_ENTITY	The peripheral_benzodiazepine_receptor ligand 1 - -LRB- 2-chlorophenyl-methylpropyl -RRB- -3 - isoquinoline-carboxamide is a novel antagonist of human constitutive_androstane_receptor .
8583222	0	peripheral_myelin_protein-22	45,73	PMP-22	75,81	peripheral myelin protein-22	PMP-22	5376	5376	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deletion in chromosome 17p11 .2 including the peripheral_myelin_protein-22 -LRB- PMP-22 -RRB- gene in hereditary_neuropathy with liability_to_pressure_palsies .
12056842	0	peripheral_myelin_protein_22	47,75	PMP22	77,82	peripheral myelin protein 22	PMP22	18858(Tax:10090)	18858(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the regulatory region of the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- gene that directs temporal and spatial expression in development and regeneration of peripheral nerves .
14664827	0	peripheral_myelin_protein_22	25,53	PMP22	55,60	peripheral myelin protein 22	PMP22	5376	5376	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Distinct elements of the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- promoter regulate expression in Schwann cells and sensory neurons .
26458320	0	peripheral_myelin_protein_22	15,43	PMP22	45,50	peripheral myelin protein 22	PMP22	5376	5376	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Suppression of peripheral_myelin_protein_22 -LRB- PMP22 -RRB- expression by miR29 inhibits the progression of lung_cancer .
8275092	0	peripheral_myelin_protein_22	63,91	PMP22	93,98	peripheral myelin protein 22	PMP22	5376	5376	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dejerine-Sottas_syndrome associated with point mutation in the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- gene .
9040744	0	peripheral_myelin_protein_22	30,58	PMP22	60,65	peripheral myelin protein 22	PMP22	5376	5376	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel point mutation in the peripheral_myelin_protein_22 -LRB- PMP22 -RRB- gene associated with Charcot-Marie-Tooth_disease_type_1A .
21533463	0	peripheral_myelin_protein_22_kDa	4,36	PMP22	38,43	peripheral myelin protein 22 kDa	PMP22	5376	5376	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The peripheral_myelin_protein_22_kDa -LRB- PMP22 -RRB- gene is amplified in cell lines derived from glioma and osteogenic_sarcoma .
8858917	0	peripherin	36,46	Interleukin-6	0,13	peripherin	Interleukin-6	24688(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signaling to promote neuronal differentiation in PC12 cells .
10426285	0	peripherin	84,94	NF-M	111,115	peripherin	NF-M	5630	4741	Gene	Gene	assembly|compound|START_ENTITY assembly|nmod|END_ENTITY	Interactions between peripherin and neurofilaments in cultured cells : disruption of peripherin assembly by the NF-M and NF-H subunits .
20363051	0	peripherin	8,18	PRPH	25,29	peripherin	PRPH	5630	5630	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A novel peripherin gene -LRB- PRPH -RRB- mutation identified in one sporadic amyotrophic_lateral_sclerosis patient .
7806235	0	peripherin	27,37	PRPH	44,48	peripherin	PRPH	5630	5630	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The structure of the human peripherin gene -LRB- PRPH -RRB- and identification of potential regulatory elements .
2632231	0	peripherin	16,26	XIF3	0,4	peripherin	XIF3	380221(Tax:8355)	380221(Tax:8355)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	XIF3 , a Xenopus peripherin gene , requires an inductive signal for enhanced expression in anterior neural tissue .
9489716	0	peripherin	40,50	leukemia_inhibitory_factor	59,85	peripherin	leukemia inhibitory factor	19132(Tax:10090)	16878(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Transcriptional activation of the mouse peripherin gene by leukemia_inhibitory_factor : involvement of STAT proteins .
8698830	0	perlecan	62,70	heparan_sulfate_proteoglycan	32,60	perlecan	heparan sulfate proteoglycan	313641(Tax:10116)	25615(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Regulation of basement membrane heparan_sulfate_proteoglycan , perlecan , gene expression in glomerular epithelial cells by high glucose medium .
26530238	0	peroxidase	38,48	APX	50,53	peroxidase	APX	543959(Tax:4081)	778224(Tax:4081)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Roles of catalase -LRB- CAT -RRB- and ascorbate peroxidase -LRB- APX -RRB- genes in stress response of eggplant -LRB- Solanum melongena L. -RRB- against Cu -LRB- +2 -RRB- and Zn -LRB- +2 -RRB- heavy metal stresses .
24482432	0	peroxidase	78,88	FtSH4	58,63	peroxidase	FtSH4	816773(Tax:3702)	817154(Tax:3702)	Gene	Gene	accumulation|compound|START_ENTITY accumulation|amod|END_ENTITY	Perturbation of auxin homeostasis caused by mitochondrial FtSH4 gene-mediated peroxidase accumulation regulates arabidopsis architecture .
24080581	0	peroxidase	18,28	POD	30,33	peroxidase	POD	543959(Tax:4081)	543959(Tax:4081)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Fast detection of peroxidase -LRB- POD -RRB- activity in tomato leaves which infected with Botrytis_cinerea using hyperspectral imaging .
15257762	0	peroxidase	41,51	ZmPox3	28,34	peroxidase	ZmPox3	542029(Tax:4577)	542505(Tax:4577)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Nucleotide diversity of the ZmPox3 maize peroxidase gene : relationships between a MITE insertion in exon 2 and variation in forage maize digestibility .
12861054	0	peroxiredoxin-3	38,53	thioredoxin_peroxidase-2	55,79	peroxiredoxin-3	thioredoxin peroxidase-2	11757(Tax:10090)	18477(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Increased expression of mitochondrial peroxiredoxin-3 -LRB- thioredoxin_peroxidase-2 -RRB- protects cancer cells against hypoxia and drug-induced hydrogen_peroxide-dependent apoptosis .
16677601	0	peroxiredoxin-I	72,87	Transforming_growth_factor-beta1	0,32	peroxiredoxin-I	Transforming growth factor-beta1	5052	7040	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Transforming_growth_factor-beta1 induces the non-classical secretion of peroxiredoxin-I in A549 cells .
23227829	0	peroxiredoxin_3	56,71	MiR-383	0,7	peroxiredoxin 3	MiR-383	10935	494332	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nsubjpass|END_ENTITY	MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin_3 -LRB- PRDX3 -RRB- .
20354123	0	peroxiredoxin_6	29,44	Phospholipase_A2	0,16	peroxiredoxin 6	Phospholipase A2	9588	151056	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Phospholipase_A2 activity of peroxiredoxin_6 promotes invasion and metastasis of lung_cancer cells .
16186110	0	peroxiredoxin_6	140,155	Saitohin	0,8	peroxiredoxin 6	Saitohin	9588	246744	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Saitohin , which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative_diseases , interacts with peroxiredoxin_6 .
26398495	0	peroxiredoxin_6	6,21	anion_exchanger_1	37,54	peroxiredoxin 6	anion exchanger 1	11758(Tax:10090)	20533(Tax:10090)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Renal peroxiredoxin_6 interacts with anion_exchanger_1 and plays a novel role in pH homeostasis .
25637741	0	peroxiredoxin_6	47,62	phospholipase_A2	18,34	peroxiredoxin 6	phospholipase A2	11758(Tax:10090)	18784(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Inhibition of the phospholipase_A2 activity of peroxiredoxin_6 prevents lung_damage with exposure to hyperoxia .
17050172	0	peroxiredoxin_II	21,37	Prx_II	39,45	peroxiredoxin II	Prx II	21672(Tax:10090)	21672(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of peroxiredoxin_II -LRB- Prx_II -RRB- on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast -LRB- MEF -RRB- senescence .
18442801	0	peroxiredoxin_II	21,37	toll-like_receptor_4	67,87	peroxiredoxin II	toll-like receptor 4	21672(Tax:10090)	21898(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Differential role of peroxiredoxin_II -LRB- PrxII -RRB- on the expression of toll-like_receptor_4 -LRB- TLR4 -RRB- and B-cell_activating_factor -LRB- BAFF -RRB- in ovalbumin -LRB- OVA -RRB- - induced mouse asthma .
18195003	0	peroxiredoxin_III	17,34	FOXO3A	0,6	peroxiredoxin III	FOXO3A	10935	2309	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FOXO3A regulates peroxiredoxin_III expression in human cardiac fibroblasts .
22710126	0	peroxiredoxin_III	27,44	MicroRNA-23b	0,12	peroxiredoxin III	MicroRNA-23b	10935	407011	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	MicroRNA-23b downregulates peroxiredoxin_III in human prostate_cancer .
19408305	0	peroxiredoxin_III	41,58	c-MYC	22,27	peroxiredoxin III	c-MYC	10935	4609	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Downregulation of the c-MYC target gene , peroxiredoxin_III , contributes to arsenic_trioxide-induced apoptosis in acute_promyelocytic_leukemia .
9599016	0	peroxisomal_membrane_protein-1-like_protein	63,106	PXMP1-L	108,115	peroxisomal membrane protein-1-like protein	PXMP1-L	5826	5826	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and chromosomal localization of the human peroxisomal_membrane_protein-1-like_protein -LRB- PXMP1-L -RRB- gene encoding a peroxisomal ABC_transporter .
11389700	0	peroxisome-proliferator-activated_receptor	14,56	PPAR	58,62	peroxisome-proliferator-activated receptor	PPAR	5465	5465	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of peroxisome-proliferator-activated_receptor -LRB- PPAR -RRB- alpha by MK886 .
16277686	0	peroxisome-proliferator-activated_receptor	23,65	PPAR	67,71	peroxisome-proliferator-activated receptor	PPAR	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Contrasting effects of peroxisome-proliferator-activated_receptor -LRB- PPAR -RRB- gamma agonists on membrane-associated prostaglandin_E2 synthase-1 in IL-1beta-stimulated rat chondrocytes : evidence for PPARgamma-independent inhibition by 15-deoxy-Delta12 ,14 prostaglandin_J2 .
12678921	0	peroxisome-proliferator-activated_receptor-gamma_co-activator_1_beta	56,124	PGC1_beta	45,54	peroxisome-proliferator-activated receptor-gamma co-activator 1 beta	PGC1 beta	291567(Tax:10116)	291567(Tax:10116)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Characterization of the human , mouse and rat PGC1_beta -LRB- peroxisome-proliferator-activated_receptor-gamma_co-activator_1_beta -RRB- gene in vitro and in vivo .
15500444	0	peroxisome-proliferator-activated_receptor_alpha	54,102	CLOCK	0,5	peroxisome-proliferator-activated receptor alpha	CLOCK	19013(Tax:10090)	12753(Tax:10090)	Gene	Gene	transactivation|nmod|START_ENTITY involved|nmod|transactivation involved|nsubjpass|END_ENTITY	CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in mice .
12866036	0	peroxisome-proliferator_activated_receptor-gamma	14,62	PGC-1	107,112	peroxisome-proliferator activated receptor-gamma	PGC-1	5468	10891	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Expression of peroxisome-proliferator_activated_receptor-gamma -LRB- PPARgamma -RRB- and the PPARgamma co-activator , PGC-1 , in human breast_cancer correlates with clinical outcomes .
8043297	0	peroxisome_assembly_factor-1	38,66	PMP35	68,73	peroxisome assembly factor-1	PMP35	5828	5828	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Structure and expression of mammalian peroxisome_assembly_factor-1 -LRB- PMP35 -RRB- genes .
10408779	0	peroxisome_assembly_factor-2	72,100	PEX6	66,70	peroxisome assembly factor-2	PEX6	5190	5190	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Genomic structure and identification of 11 novel mutations of the PEX6 -LRB- peroxisome_assembly_factor-2 -RRB- gene in patients with peroxisome_biogenesis_disorders .
9702044	0	peroxisome_proliferation-activated_receptor	102,145	PPAR	147,151	peroxisome proliferation-activated receptor	PPAR	5465	5465	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Lipid metabolism related nuclear receptor -- the structure , function , expression and classification of peroxisome_proliferation-activated_receptor -LRB- PPAR -RRB- -RSB- .
10953038	0	peroxisome_proliferator-activated_receptor	13,55	PPAR	57,61	peroxisome proliferator-activated receptor	PPAR	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	proliferation|amod|START_ENTITY proliferation|appos|END_ENTITY	Evidence for peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- alpha-independent peroxisome proliferation : effects of PPARgamma/delta-specific agonists in PPARalpha-null mice .
11095972	0	peroxisome_proliferator-activated_receptor	20,62	PPAR	64,68	peroxisome proliferator-activated receptor	PPAR	5465	5465	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of human peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- subtypes by pioglitazone .
14646253	0	peroxisome_proliferator-activated_receptor	20,62	PPAR	64,68	peroxisome proliferator-activated receptor	PPAR	5465	5465	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of human peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- subtype selectivity of a variety of anti-inflammatory drugs based on a novel assay for PPAR_delta -LRB- beta -RRB- .
17663016	0	peroxisome_proliferator-activated_receptor	37,79	PPAR	81,85	peroxisome proliferator-activated receptor	PPAR	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Urine acidification has no effect on peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- signaling or epidermal_growth_factor -LRB- EGF -RRB- expression in rat urinary bladder urothelium .
17763950	0	peroxisome_proliferator-activated_receptor	13,55	PPAR	57,61	peroxisome proliferator-activated receptor	PPAR	5465	5465	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- gamma Plo12Ala polymorphism as a shared risk marker for both gastric_cancer and impaired_fasting_glucose -LRB- IFG -RRB- in Japanese .
19172665	0	peroxisome_proliferator-activated_receptor	89,131	PPAR	133,137	peroxisome proliferator-activated receptor	PPAR	5465	5465	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Identification of plant extracts with potential antidiabetic properties : effect on human peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- , adipocyte differentiation and insulin-stimulated glucose uptake .
21530275	0	peroxisome_proliferator-activated_receptor	117,159	PPAR	161,165	peroxisome proliferator-activated receptor	PPAR	5465	5465	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Structure-based design , synthesis , and nonalcoholic_steatohepatitis -LRB- NASH -RRB- - preventive effect of phenylpropanoic_acid peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- a-selective agonists .
8651933	0	peroxisome_proliferator-activated_receptor	18,60	PPAR	62,66	peroxisome proliferator-activated receptor	PPAR	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- in the mouse colonic mucosa .
23766515	0	peroxisome_proliferator-activated_receptor	37,79	Sphingosine_kinase_1	0,20	peroxisome proliferator-activated receptor	Sphingosine kinase 1	19013(Tax:10090)	20698(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Sphingosine_kinase_1 is regulated by peroxisome_proliferator-activated_receptor a in response to free fatty_acids and is essential for skeletal muscle interleukin-6 production and signaling in diet-induced obesity .
11840453	0	peroxisome_proliferator-activated_receptor	66,108	cyclooxygenase_2	122,138	peroxisome proliferator-activated receptor	cyclooxygenase 2	5465	5743	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Nimesulide , a preferential cyclooxygenase_2 inhibitor , suppresses peroxisome_proliferator-activated_receptor induction of cyclooxygenase_2 gene expression in human synovial fibroblasts : evidence for receptor antagonism .
12095700	0	peroxisome_proliferator-activated_receptor	53,95	p300	29,33	peroxisome proliferator-activated receptor	p300	5465	2033	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Major intestinal coactivator p300 strongly activates peroxisome_proliferator-activated_receptor in intestinal cell line , Caco-2 .
23681751	0	peroxisome_proliferator-activated_receptor-a	69,113	PPAR-a	115,121	peroxisome proliferator-activated receptor-a	PPAR-a	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Dill seed extract improves abnormalities in lipid metabolism through peroxisome_proliferator-activated_receptor-a -LRB- PPAR-a -RRB- activation in diabetic_obese mice .
21640707	0	peroxisome_proliferator-activated_receptor-a	14,58	PPARa	60,65	peroxisome proliferator-activated receptor-a	PPARa	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-a -LRB- PPARa -RRB- suppresses postprandial_lipidemia through fatty_acid oxidation in enterocytes .
19103650	0	peroxisome_proliferator-activated_receptor-alpha	14,62	MDM2	66,70	peroxisome proliferator-activated receptor-alpha	MDM2	19013(Tax:10090)	17246(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of peroxisome_proliferator-activated_receptor-alpha by MDM2 .
17261654	0	peroxisome_proliferator-activated_receptor-alpha	81,129	PGC-1alpha	130,140	peroxisome proliferator-activated receptor-alpha	PGC-1alpha	19013(Tax:10090)	19017(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome_proliferator-activated_receptor-alpha / PGC-1alpha gene regulatory pathway .
16369181	0	peroxisome_proliferator-activated_receptor-alpha	19,67	PPAR-alpha	69,79	peroxisome proliferator-activated receptor-alpha	PPAR-alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	ROLE|nmod|START_ENTITY ROLE|appos|END_ENTITY	ROLE of endogenous peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- ligands in the development of gut ischemia and reperfusion in mice .
16501055	0	peroxisome_proliferator-activated_receptor-alpha	16,64	PPAR-alpha	66,76	peroxisome proliferator-activated receptor-alpha	PPAR-alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- in the regulation of acute inflammation .
19503102	0	peroxisome_proliferator-activated_receptor-alpha	4,52	PPAR-alpha	54,64	peroxisome proliferator-activated receptor-alpha	PPAR-alpha	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	The peroxisome_proliferator-activated_receptor-alpha -LRB- PPAR-alpha -RRB- agonist , AVE8134 , attenuates the progression of heart_failure and increases survival in rats .
17317762	0	peroxisome_proliferator-activated_receptor-alpha	39,87	PPARA	94,99	peroxisome proliferator-activated receptor-alpha	PPARA	5465	5465	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms of the peroxisome_proliferator-activated_receptor-alpha gene -LRB- PPARA -RRB- influence the conversion from impaired_glucose_tolerance_to_type_2_diabetes : the STOP-NIDDM trial .
20654716	0	peroxisome_proliferator-activated_receptor-alpha	13,61	PPARa	63,68	peroxisome proliferator-activated receptor-alpha	PPARa	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Influence of peroxisome_proliferator-activated_receptor-alpha -LRB- PPARa -RRB- activity on adverse effects associated with amiodarone exposure in mice .
12740007	0	peroxisome_proliferator-activated_receptor-alpha	27,75	PPARalpha	77,86	peroxisome proliferator-activated receptor-alpha	PPARalpha	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Acute -LRB- 24 h -RRB- activation of peroxisome_proliferator-activated_receptor-alpha -LRB- PPARalpha -RRB- reverses high-fat feeding-induced insulin hypersecretion in vivo and in perifused pancreatic islets .
15447978	0	peroxisome_proliferator-activated_receptor-alpha	8,56	PPARalpha	58,67	peroxisome proliferator-activated receptor-alpha	PPARalpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of peroxisome_proliferator-activated_receptor-alpha -LRB- PPARalpha -RRB- in bezafibrate-induced hepatocarcinogenesis and cholestasis .
12756242	0	peroxisome_proliferator-activated_receptor-alpha	212,260	UCP-2	286,291	peroxisome proliferator-activated receptor-alpha	UCP-2	25747(Tax:10116)	54315(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|expression expression|compound|END_ENTITY	Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling_protein_2 -LRB- UCP-2 -RRB- expression : evidence for peroxisome_proliferator-activated_receptor-alpha independent induction of UCP-2 expression .
16150867	0	peroxisome_proliferator-activated_receptor-gamma	60,108	3-phosphoinositide-dependent_protein_kinase-1	0,45	peroxisome proliferator-activated receptor-gamma	3-phosphoinositide-dependent protein kinase-1	5468	5163	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	3-phosphoinositide-dependent_protein_kinase-1 activates the peroxisome_proliferator-activated_receptor-gamma and promotes adipocyte differentiation .
18495890	0	peroxisome_proliferator-activated_receptor-gamma	23,71	CITED2	0,6	peroxisome proliferator-activated receptor-gamma	CITED2	5468	10370	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	CITED2 signals through peroxisome_proliferator-activated_receptor-gamma to regulate death of cortical neurons after DNA damage .
10102684	0	peroxisome_proliferator-activated_receptor-gamma	48,96	Insulin	0,7	peroxisome proliferator-activated receptor-gamma	Insulin	5468	3630	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Insulin acutely regulates the expression of the peroxisome_proliferator-activated_receptor-gamma in human adipocytes .
12426306	0	peroxisome_proliferator-activated_receptor-gamma	39,87	KLF2	25,29	peroxisome proliferator-activated receptor-gamma	KLF2	5468	10365	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	The Kr ppel-like factor KLF2 inhibits peroxisome_proliferator-activated_receptor-gamma expression and adipogenesis .
11712859	0	peroxisome_proliferator-activated_receptor-gamma	11,59	PPAR-gamma	61,71	peroxisome proliferator-activated receptor-gamma	PPAR-gamma	5468	5468	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytes .
12609711	0	peroxisome_proliferator-activated_receptor-gamma	29,77	PPAR-gamma	79,89	peroxisome proliferator-activated receptor-gamma	PPAR-gamma	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR-gamma -RRB- gene and risk of prostate_cancer among men in a large cancer prevention study .
17921408	0	peroxisome_proliferator-activated_receptor-gamma	21,69	PPARG	76,81	peroxisome proliferator-activated receptor-gamma	PPARG	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ala12 variant of the peroxisome_proliferator-activated_receptor-gamma gene -LRB- PPARG -RRB- is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial_infarction .
19846795	0	peroxisome_proliferator-activated_receptor-gamma	46,94	PPARG2	96,102	peroxisome proliferator-activated receptor-gamma	PPARG2	5468	5468	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Breast-feeding modulates the influence of the peroxisome_proliferator-activated_receptor-gamma -LRB- PPARG2 -RRB- Pro12Ala polymorphism on adiposity in adolescents : The Healthy Lifestyle in Europe by Nutrition in Adolescence -LRB- HELENA -RRB- cross-sectional study .
14534304	1	peroxisome_proliferator-activated_receptor-gamma	71,119	PPAR_gamma	121,131	peroxisome proliferator-activated receptor-gamma	PPAR gamma	5468	5468	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor-gamma -LRB- PPAR_gamma -RRB- agonists and 9-cis-retinoic_acid .
16616945	0	peroxisome_proliferator-activated_receptor-gamma	14,62	PPARgamma	64,73	peroxisome proliferator-activated receptor-gamma	PPARgamma	5468	5468	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- induces cell death through MAPK-dependent mechanism in osteoblastic cells .
18072811	0	peroxisome_proliferator-activated_receptor-gamma	12,60	PPARgamma	62,71	peroxisome proliferator-activated receptor-gamma	PPARgamma	5468	5468	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- in Alzheimer 's _ disease : therapeutic implications .
18565023	0	peroxisome_proliferator-activated_receptor-gamma	8,56	PPARgamma	58,67	peroxisome proliferator-activated receptor-gamma	PPARgamma	25664(Tax:10116)	25664(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- during liver_regeneration in rats .
19104705	0	peroxisome_proliferator-activated_receptor-gamma	29,77	PPARgamma	79,88	peroxisome proliferator-activated receptor-gamma	PPARgamma	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- gene in inflammatory_bowel_disease .
15685547	0	peroxisome_proliferator-activated_receptor-gamma	11,59	SAMP1/YitFc	63,74	peroxisome proliferator-activated receptor-gamma	SAMP1/YitFc	19016(Tax:10090)	230917(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Linkage to peroxisome_proliferator-activated_receptor-gamma in SAMP1/YitFc mice and in human Crohn 's _ disease .
11815513	0	peroxisome_proliferator-activated_receptor-gamma	10,58	adiponectin	110,121	peroxisome proliferator-activated receptor-gamma	adiponectin	5468	9370	Gene	Gene	agonist|amod|START_ENTITY increases|nsubj|agonist increases|dobj|levels levels|nmod|END_ENTITY	Synthetic peroxisome_proliferator-activated_receptor-gamma agonist , rosiglitazone , increases plasma levels of adiponectin in type 2 diabetic patients .
17947702	0	peroxisome_proliferator-activated_receptor-gamma	102,150	adrenomedullin	19,33	peroxisome proliferator-activated receptor-gamma	adrenomedullin	5468	133	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Vasoactive hormone adrenomedullin and its binding protein : anti-inflammatory effects by up-regulating peroxisome_proliferator-activated_receptor-gamma .
19118280	0	peroxisome_proliferator-activated_receptor-gamma	15,63	angiotensin_II	76,90	peroxisome proliferator-activated receptor-gamma	angiotensin II	5468	183	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Suppression of peroxisome_proliferator-activated_receptor-gamma activity by angiotensin_II in vascular smooth muscle involves Bcr kinase : the fire that drowns the water .
12736714	0	peroxisome_proliferator-activated_receptor-gamma	49,97	cyclooxygenase-2	14,30	peroxisome proliferator-activated receptor-gamma	cyclooxygenase-2	5468	5743	Gene	Gene	synergistically|amod|START_ENTITY END_ENTITY|nmod|synergistically	Inhibition of cyclooxygenase-2 and activation of peroxisome_proliferator-activated_receptor-gamma synergistically induces apoptosis and inhibits growth of human breast_cancer cells .
14749268	0	peroxisome_proliferator-activated_receptor-gamma	38,86	glucokinase	6,17	peroxisome proliferator-activated receptor-gamma	glucokinase	25664(Tax:10116)	24385(Tax:10116)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Liver glucokinase can be activated by peroxisome_proliferator-activated_receptor-gamma .
12957321	0	peroxisome_proliferator-activated_receptor-gamma	38,86	insulin	105,112	peroxisome proliferator-activated receptor-gamma	insulin	5468	3630	Gene	Gene	role|nmod|START_ENTITY role|nmod|progression progression|nmod|resistance resistance|compound|END_ENTITY	The central role of fat and effect of peroxisome_proliferator-activated_receptor-gamma on progression of insulin resistance and cardiovascular_disease .
18310298	0	peroxisome_proliferator-activated_receptor-gamma	50,98	insulin_receptor	4,20	peroxisome proliferator-activated receptor-gamma	insulin receptor	5468	3643	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	The insulin_receptor : a new anticancer target for peroxisome_proliferator-activated_receptor-gamma -LRB- PPARgamma -RRB- and thiazolidinedione-PPARgamma agonists .
19289654	0	peroxisome_proliferator-activated_receptor-gamma	112,160	interleukin-6	50,63	peroxisome proliferator-activated receptor-gamma	interleukin-6	25664(Tax:10116)	24498(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|expression expression|amod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome_proliferator-activated_receptor-gamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta .
15504954	0	peroxisome_proliferator-activated_receptor-gamma	14,62	mammalian_target_of_rapamycin	75,104	peroxisome proliferator-activated receptor-gamma	mammalian target of rapamycin	5468	2475	Gene	Gene	activity|amod|START_ENTITY regulation|nmod|activity regulation|nmod|END_ENTITY	regulation of peroxisome_proliferator-activated_receptor-gamma activity by mammalian_target_of_rapamycin and amino_acids in adipogenesis .
15917242	0	peroxisome_proliferator-activated_receptor-gamma	4,52	pyruvate_carboxylase	70,90	peroxisome proliferator-activated receptor-gamma	pyruvate carboxylase	19016(Tax:10090)	18563(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The peroxisome_proliferator-activated_receptor-gamma regulates murine pyruvate_carboxylase gene expression in vivo and in vitro .
11416035	0	peroxisome_proliferator-activated_receptor-gamma	81,129	type_1_angiotensin_II_receptor	31,61	peroxisome proliferator-activated receptor-gamma	type 1 angiotensin II receptor	25664(Tax:10116)	24180(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcriptional suppression of type_1_angiotensin_II_receptor gene expression by peroxisome_proliferator-activated_receptor-gamma in vascular smooth muscle cells .
11596673	0	peroxisome_proliferator-activated_receptor-gamma2	44,93	PPAR-gamma2	95,106	peroxisome proliferator-activated receptor-gamma2	PPAR-gamma2	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Studies of the Pro12Ala polymorphism of the peroxisome_proliferator-activated_receptor-gamma2 -LRB- PPAR-gamma2 -RRB- gene in relation to insulin sensitivity among glucose tolerant caucasians .
20179158	0	peroxisome_proliferator-activated_receptor-gamma2	28,77	PPARG2	79,85	peroxisome proliferator-activated receptor-gamma2	PPARG2	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The association between the peroxisome_proliferator-activated_receptor-gamma2 -LRB- PPARG2 -RRB- Pro12Ala gene variant and type_2_diabetes_mellitus : a HuGE review and meta-analysis .
17439324	0	peroxisome_proliferator-activated_receptor-gamma2	29,78	PPARgamma-2	80,91	peroxisome proliferator-activated receptor-gamma2	PPARgamma-2	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pro12Ala polymorphism of the peroxisome_proliferator-activated_receptor-gamma2 -LRB- PPARgamma-2 -RRB- gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population .
16051671	0	peroxisome_proliferator-activated_receptor-gamma_coactivator-1alpha	154,221	Hepatocyte_nuclear_factor-4alpha	0,32	peroxisome proliferator-activated receptor-gamma coactivator-1alpha	Hepatocyte nuclear factor-4alpha	10891	3172	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Hepatocyte_nuclear_factor-4alpha regulates the human apolipoprotein_AV gene : identification of a novel response element and involvement in the control by peroxisome_proliferator-activated_receptor-gamma_coactivator-1alpha , AMP-activated_protein_kinase , and mitogen-activated protein kinase pathway .
21317313	0	peroxisome_proliferator-activated_receptor-y	85,129	Leptin	0,6	peroxisome proliferator-activated receptor-y	Leptin	5468	3952	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	Leptin promotes fibroproliferative acute_respiratory_distress_syndrome by inhibiting peroxisome_proliferator-activated_receptor-y .
19587804	0	peroxisome_proliferator-activated_receptor-y	25,69	PPARy	71,76	peroxisome proliferator-activated receptor-y	PPARy	5468	5468	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	New target genes for the peroxisome_proliferator-activated_receptor-y -LRB- PPARy -RRB- antitumour activity : Perspectives from the insulin_receptor .
25592041	0	peroxisome_proliferator-activated_receptor-y	14,58	PPARy	60,65	peroxisome proliferator-activated receptor-y	PPARy	5468	5468	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-y -LRB- PPARy -RRB- inhibits hepatoma cell growth via downregulation of SEPT2 expression .
26072064	0	peroxisome_proliferator-activated_receptor-y	18,62	TNF-a	96,101	peroxisome proliferator-activated receptor-y	TNF-a	5468	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Crosstalk between peroxisome_proliferator-activated_receptor-y and mineralcorticoid receptor in TNF-a activated renal tubular cell .
24424044	0	peroxisome_proliferator-activated_receptor_a	57,101	CREBH	36,41	peroxisome proliferator-activated receptor a	CREBH	19013(Tax:10090)	208677(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Liver-enriched transcription factor CREBH interacts with peroxisome_proliferator-activated_receptor_a to regulate metabolic hormone FGF21 .
20738325	0	peroxisome_proliferator-activated_receptor_a	50,94	Leptin	0,6	peroxisome proliferator-activated receptor a	Leptin	25747(Tax:10116)	25608(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY activating|dobj|pathway induces|advcl|activating induces|nsubj|END_ENTITY	Leptin induces hypertrophy through activating the peroxisome_proliferator-activated_receptor_a pathway in cultured neonatal rat cardiomyocytes .
22932900	0	peroxisome_proliferator-activated_receptor_a	14,58	PPARa	60,65	peroxisome proliferator-activated receptor a	PPARa	5465	5465	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_a -LRB- PPARa -RRB- suppresses hypoxia-inducible_factor-1a -LRB- HIF-1a -RRB- signaling in cancer cells .
24713062	0	peroxisome_proliferator-activated_receptor_a	39,83	liver_X_receptor_a	89,107	peroxisome proliferator-activated receptor a	liver X receptor a	5465	10062	Gene	Gene	heterodimerization|nmod|START_ENTITY heterodimerization|nmod|END_ENTITY	Ligand-regulated heterodimerization of peroxisome_proliferator-activated_receptor_a with liver_X_receptor_a .
23295386	0	peroxisome_proliferator-activated_receptor_alpha	83,131	CYP3A4	72,78	peroxisome proliferator-activated receptor alpha	CYP3A4	5465	1576	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Direct transcriptional regulation of human hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARa -RRB- .
17462989	0	peroxisome_proliferator-activated_receptor_alpha	137,185	Cidea	30,35	peroxisome proliferator-activated receptor alpha	Cidea	19013(Tax:10090)	12683(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Cidea , mitochondrial cell_death-inducing_DNA_fragmentation_factor_alpha-like_effector_A , in mouse liver by peroxisome_proliferator-activated_receptor_alpha and gamma .
16571721	0	peroxisome_proliferator-activated_receptor_alpha	104,152	MLDP	0,4	peroxisome proliferator-activated receptor alpha	MLDP	19013(Tax:10090)	66968(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	MLDP , a novel PAT family protein localized to lipid droplets and enriched in the heart , is regulated by peroxisome_proliferator-activated_receptor_alpha .
19819229	0	peroxisome_proliferator-activated_receptor_alpha	37,85	OCTN2	6,11	peroxisome proliferator-activated receptor alpha	OCTN2	19013(Tax:10090)	20518(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Mouse OCTN2 is directly regulated by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- via a PPRE located in the first intron .
18955051	0	peroxisome_proliferator-activated_receptor_alpha	44,92	PDZK1	24,29	peroxisome proliferator-activated receptor alpha	PDZK1	5465	5174	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of the human PDZK1 expression by peroxisome_proliferator-activated_receptor_alpha .
20087658	0	peroxisome_proliferator-activated_receptor_alpha	25,73	PPARA	80,85	peroxisome proliferator-activated receptor alpha	PPARA	374120(Tax:9031)	374120(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation of the peroxisome_proliferator-activated_receptor_alpha gene -LRB- PPARA -RRB- in chickens bred for different purposes .
10471118	0	peroxisome_proliferator-activated_receptor_alpha	16,64	PPAR_alpha	66,76	peroxisome proliferator-activated receptor alpha	PPAR alpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the peroxisome_proliferator-activated_receptor_alpha -LRB- PPAR_alpha -RRB- in the control of cardiac lipid metabolism .
9610365	0	peroxisome_proliferator-activated_receptor_alpha	14,62	PPAR_alpha	64,74	peroxisome proliferator-activated receptor alpha	PPAR alpha	5465	5465	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_alpha -LRB- PPAR_alpha -RRB- in primary cultures of human vascular endothelial cells .
11409711	0	peroxisome_proliferator-activated_receptor_alpha	30,78	PPARalpha	80,89	peroxisome proliferator-activated receptor alpha	PPARalpha	5465	5465	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism , L162V , in the peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- gene is associated with lower body mass index in patients with non-insulin-dependent_diabetes_mellitus .
11734553	0	peroxisome_proliferator-activated_receptor_alpha	11,59	PPARalpha	61,70	peroxisome proliferator-activated receptor alpha	PPARalpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- in the control of cardiac malonyl-CoA levels : reduced fatty_acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA_decarboxylase .
11994294	0	peroxisome_proliferator-activated_receptor_alpha	12,60	PPARalpha	62,71	peroxisome proliferator-activated receptor alpha	PPARalpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	agonist|compound|START_ENTITY agonist|appos|END_ENTITY	WY14 ,643 , a peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- agonist , improves hepatic and muscle_steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F -1 mice .
12580534	0	peroxisome_proliferator-activated_receptor_alpha	25,73	PPARalpha	75,84	peroxisome proliferator-activated receptor alpha	PPARalpha	5465	5465	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Functional activation of peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- by environmental chemicals in relation to their toxicities .
15837165	0	peroxisome_proliferator-activated_receptor_alpha	29,77	PPARalpha	79,88	peroxisome proliferator-activated receptor alpha	PPARalpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Reduced LPA expression after peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- activation in LPA-YAC transgenic_mice .
18602970	0	peroxisome_proliferator-activated_receptor_alpha	11,59	PPARalpha	61,70	peroxisome proliferator-activated receptor alpha	PPARalpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- agonists on leucine-induced phosphorylation of translational targets in C2C12 cells .
20637823	0	peroxisome_proliferator-activated_receptor_alpha	19,67	PPARalpha	69,78	peroxisome proliferator-activated receptor alpha	PPARalpha	19013(Tax:10090)	19013(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of prenatal peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- agonism on postnatal development .
19748481	0	peroxisome_proliferator-activated_receptor_alpha	47,95	SLC25A20	24,32	peroxisome proliferator-activated receptor alpha	SLC25A20	5465	788	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of the human SLC25A20 expression by peroxisome_proliferator-activated_receptor_alpha in human hepatoblastoma cells .
21540177	0	peroxisome_proliferator-activated_receptor_alpha	59,107	SREBP1c	6,13	peroxisome proliferator-activated receptor alpha	SREBP1c	5465	6720	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Human SREBP1c expression in liver is directly regulated by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARalpha -RRB- .
23295386	0	peroxisome_proliferator-activated_receptor_alpha	83,131	cytochrome_P450_3A4	51,70	peroxisome proliferator-activated receptor alpha	cytochrome P450 3A4	5465	1576	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Direct transcriptional regulation of human hepatic cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- by peroxisome_proliferator-activated_receptor_alpha -LRB- PPARa -RRB- .
17105827	0	peroxisome_proliferator-activated_receptor_alpha	0,48	endothelin-1	83,95	peroxisome proliferator-activated receptor alpha	endothelin-1	5465	1906	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|production production|amod|END_ENTITY	peroxisome_proliferator-activated_receptor_alpha activation-mediated regulation of endothelin-1 production via nitric_oxide and protein_kinase_C signaling pathways in piglet cerebral microvascular endothelial cell culture .
9354589	0	peroxisome_proliferator-activated_receptor_alpha	25,73	interleukin-1beta	88,105	peroxisome proliferator-activated receptor alpha	interleukin-1beta	25747(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|acl|END_ENTITY	Regulation of CYP4A1 and peroxisome_proliferator-activated_receptor_alpha expression by interleukin-1beta , interleukin-6 , and dexamethasone in cultured fetal rat hepatocytes .
9407140	0	peroxisome_proliferator-activated_receptor_alpha	40,88	p300	0,4	peroxisome proliferator-activated receptor alpha	p300	19013(Tax:10090)	328572(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	p300 functions as a coactivator for the peroxisome_proliferator-activated_receptor_alpha .
12753917	0	peroxisome_proliferator-activated_receptor_alpha	78,126	retinoid_X_receptor_alpha	33,58	peroxisome proliferator-activated receptor alpha	retinoid X receptor alpha	19013(Tax:10090)	20181(Tax:10090)	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	In vivo stabilization of nuclear retinoid_X_receptor_alpha in the presence of peroxisome_proliferator-activated_receptor_alpha .
19951549	0	peroxisome_proliferator-activated_receptor_beta	9,56	epidermal_growth_factor	85,108	peroxisome proliferator-activated receptor beta	epidermal growth factor	5467	1950	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|effect effect|nmod|END_ENTITY	-LSB- Role of peroxisome_proliferator-activated_receptor_beta in the inhibitory effect of epidermal_growth_factor on apoptosis of HaCaT -RSB- .
20308079	0	peroxisome_proliferator-activated_receptor_delta	59,107	Long_chain_acyl-CoA_synthetase-3	0,32	peroxisome proliferator-activated receptor delta	Long chain acyl-CoA synthetase-3	5467	2181	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Long_chain_acyl-CoA_synthetase-3 is a molecular target for peroxisome_proliferator-activated_receptor_delta in HepG2 hepatoma cells .
15733729	0	peroxisome_proliferator-activated_receptor_delta	19,67	PPAR_delta	69,79	peroxisome proliferator-activated receptor delta	PPAR delta	5467	5467	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Regulatory role of peroxisome_proliferator-activated_receptor_delta -LRB- PPAR_delta -RRB- in muscle metabolism .
14555539	0	peroxisome_proliferator-activated_receptor_gamma	41,89	COX-2	11,16	peroxisome proliferator-activated receptor gamma	COX-2	5468	4513	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Control of COX-2 gene expression through peroxisome_proliferator-activated_receptor_gamma in human cervical_cancer cells .
19056168	0	peroxisome_proliferator-activated_receptor_gamma	38,86	COX-2	14,19	peroxisome proliferator-activated receptor gamma	COX-2	5468	5743	Gene	Gene	synergistically|amod|START_ENTITY END_ENTITY|nmod|synergistically	Inhibition of COX-2 and activation of peroxisome_proliferator-activated_receptor_gamma synergistically inhibits proliferation and induces apoptosis of human pancreatic_carcinoma cells .
16260612	0	peroxisome_proliferator-activated_receptor_gamma	54,102	Cyclin_D3	0,9	peroxisome proliferator-activated receptor gamma	Cyclin D3	19016(Tax:10090)	12445(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|END_ENTITY	Cyclin_D3 promotes adipogenesis through activation of peroxisome_proliferator-activated_receptor_gamma .
25637537	0	peroxisome_proliferator-activated_receptor_gamma	71,119	Cysteine_dioxygenase_type_1	0,27	peroxisome proliferator-activated receptor gamma	Cysteine dioxygenase type 1	19016(Tax:10090)	1036	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Cysteine_dioxygenase_type_1 promotes adipogenesis via interaction with peroxisome_proliferator-activated_receptor_gamma .
20185831	0	peroxisome_proliferator-activated_receptor_gamma	66,114	Erk5	47,51	peroxisome proliferator-activated receptor gamma	Erk5	19016(Tax:10090)	23939(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- .
23562554	0	peroxisome_proliferator-activated_receptor_gamma	26,74	FAM3A	0,5	peroxisome proliferator-activated receptor gamma	FAM3A	5468	60343	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	FAM3A is a target gene of peroxisome_proliferator-activated_receptor_gamma .
12912973	0	peroxisome_proliferator-activated_receptor_gamma	19,67	HER2	0,4	peroxisome proliferator-activated receptor gamma	HER2	5468	2064	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nummod|END_ENTITY	HER2 regulation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression and sensitivity of breast_cancer cells to PPARgamma ligand therapy .
26417420	0	peroxisome_proliferator-activated_receptor_gamma	70,118	Homeodomain_interacting_protein_kinase_2	0,40	peroxisome proliferator-activated receptor gamma	Homeodomain interacting protein kinase 2	5468	28996	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nsubjpass|END_ENTITY	Homeodomain_interacting_protein_kinase_2 is downregulated through the peroxisome_proliferator-activated_receptor_gamma signaling pathway in an insulin-resistant population .
16335797	0	peroxisome_proliferator-activated_receptor_gamma	22,70	Leptin	0,6	peroxisome proliferator-activated receptor gamma	Leptin	5468	3952	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|dobj|levels	Leptin down-regulates peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- mRNA levels in primary human monocyte-derived macrophages .
19666473	0	peroxisome_proliferator-activated_receptor_gamma	153,201	MCP-1	0,5	peroxisome proliferator-activated receptor gamma	MCP-1	19016(Tax:10090)	20296(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	MCP-1 -LRB- monocyte_chemotactic_protein-1 -RRB- - induced protein , a recently identified zinc finger protein , induces adipogenesis in 3T3-L1 pre-adipocytes without peroxisome_proliferator-activated_receptor_gamma .
25387077	0	peroxisome_proliferator-activated_receptor_gamma	57,105	MicroRNA-130b	0,13	peroxisome proliferator-activated receptor gamma	MicroRNA-130b	5468	406920	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	MicroRNA-130b promotes cell aggressiveness by inhibiting peroxisome_proliferator-activated_receptor_gamma in human hepatocellular_carcinoma .
26653558	0	peroxisome_proliferator-activated_receptor_gamma	64,112	MicroRNA-130b	0,13	peroxisome proliferator-activated receptor gamma	MicroRNA-130b	5468	406920	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-130b promotes cell migration and invasion by targeting peroxisome_proliferator-activated_receptor_gamma in human glioma .
20558736	0	peroxisome_proliferator-activated_receptor_gamma	47,95	OCTN2	6,11	peroxisome proliferator-activated receptor gamma	OCTN2	5468	6584	Gene	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubj|expression expression|compound|END_ENTITY	Colon OCTN2 gene expression is up-regulated by peroxisome_proliferator-activated_receptor_gamma in humans and mice and contributes to local and systemic carnitine homeostasis .
9708794	0	peroxisome_proliferator-activated_receptor_gamma	31,79	PBP	169,172	peroxisome proliferator-activated receptor gamma	PBP	19016(Tax:10090)	19014(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Differential expression of the peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- and its coactivators steroid_receptor_coactivator-1 and PPAR-binding_protein PBP in the brown fat , urinary_bladder , colon , and breast of the mouse .
16335797	0	peroxisome_proliferator-activated_receptor_gamma	22,70	PPAR-gamma	72,82	peroxisome proliferator-activated receptor gamma	PPAR-gamma	5468	5468	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Leptin down-regulates peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- mRNA levels in primary human monocyte-derived macrophages .
17877580	0	peroxisome_proliferator-activated_receptor_gamma	14,62	PPAR-gamma	64,74	peroxisome proliferator-activated receptor gamma	PPAR-gamma	5468	5468	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR-gamma -RRB- in canine nasal_carcinomas .
19186181	0	peroxisome_proliferator-activated_receptor_gamma	32,80	PPARG	82,87	peroxisome proliferator-activated receptor gamma	PPARG	5468	5468	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Colorectal_cancer expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARG , PPARgamma -RRB- is associated with good prognosis .
22803842	0	peroxisome_proliferator-activated_receptor_gamma	84,132	PPARG	134,139	peroxisome proliferator-activated receptor gamma	PPARG	5468	5468	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A complicated pregnancy in a patient with lipodystrophic_diabetes attributable to a peroxisome_proliferator-activated_receptor_gamma -LRB- PPARG -RRB- mutation .
25182148	0	peroxisome_proliferator-activated_receptor_gamma	33,81	PPARG	83,88	peroxisome proliferator-activated receptor gamma	PPARG	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor_gamma -LRB- PPARG -RRB- gene in relation to obesity and metabolic phenotypes in a Taiwanese population .
10674402	0	peroxisome_proliferator-activated_receptor_gamma	72,120	PPAR_gamma	122,132	peroxisome proliferator-activated receptor gamma	PPAR gamma	19016(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prolactin enhances CCAAT enhancer-binding protein-beta -LRB- C/EBP _ beta -RRB- and peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR_gamma -RRB- messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells .
12457461	0	peroxisome_proliferator-activated_receptor_gamma	41,89	PPAR_gamma	91,101	peroxisome proliferator-activated receptor gamma	PPAR gamma	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Early stimulation and late inhibition of peroxisome_proliferator-activated_receptor_gamma -LRB- PPAR_gamma -RRB- gene expression by transforming_growth_factor_beta in human aortic smooth muscle cells : role of early_growth-response_factor-1 -LRB- Egr-1 -RRB- , activator_protein_1 -LRB- AP1 -RRB- and Smads .
11043863	0	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	64,73	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in normal human pancreatic islet cells .
11205925	0	peroxisome_proliferator-activated_receptor_gamma	33,81	PPARgamma	83,92	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Novel expression and function of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in human neuroblastoma cells .
12527853	1	peroxisome_proliferator-activated_receptor_gamma	48,96	PPARgamma	98,107	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- -RSB- .
12912973	0	peroxisome_proliferator-activated_receptor_gamma	19,67	PPARgamma	69,78	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	HER2 regulation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression and sensitivity of breast_cancer cells to PPARgamma ligand therapy .
14675851	0	peroxisome_proliferator-activated_receptor_gamma	25,73	PPARgamma	75,84	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Quantitative analysis of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- expression in arteries and hearts of patients with ischaemic or dilated_cardiomyopathy .
15899154	0	peroxisome_proliferator-activated_receptor_gamma	41,89	PPARgamma	91,100	peroxisome proliferator-activated receptor gamma	PPARgamma	25664(Tax:10116)	25664(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	15-Deoxy-Delta12 ,14 - prostaglandin_J2 and peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- levels in term placental tissues from control and diabetic rats : modulatory effects of a PPARgamma agonist on nitridergic and lipid placental metabolism .
16038777	0	peroxisome_proliferator-activated_receptor_gamma	16,64	PPARgamma	66,75	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Pivotal role of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in regulation of erythroid progenitor cell proliferation and differentiation .
16574647	0	peroxisome_proliferator-activated_receptor_gamma	15,63	PPARgamma	65,74	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	Attenuation|nmod|START_ENTITY Attenuation|appos|END_ENTITY	Attenuation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- mediates gastrin-stimulated colorectal_cancer cell proliferation .
17122083	0	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	64,73	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo .
18209083	0	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	64,73	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration_of_HIV-1_infected monocytes .
20028987	0	peroxisome_proliferator-activated_receptor_gamma	8,56	PPARgamma	58,67	peroxisome proliferator-activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	activation|compound|START_ENTITY activation|appos|END_ENTITY	Chronic peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent , UCP1-containing adipocytes molecularly distinct from classic brown adipocytes .
21572083	0	peroxisome_proliferator-activated_receptor_gamma	18,66	PPARgamma	68,77	peroxisome proliferator-activated receptor gamma	PPARgamma	19016(Tax:10090)	19016(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chemerin , a novel peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- target gene that promotes mesenchymal stem cell adipogenesis .
9642130	0	peroxisome_proliferator-activated_receptor_gamma	14,62	PPARgamma	64,73	peroxisome proliferator-activated receptor gamma	PPARgamma	25664(Tax:10116)	25664(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- in rat aortic smooth muscle cells .
23266668	0	peroxisome_proliferator-activated_receptor_gamma	30,78	PPARy	85,90	peroxisome proliferator-activated receptor gamma	PPARy	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The C161T polymorphism in the peroxisome_proliferator-activated_receptor_gamma gene -LRB- PPARy -RRB- is associated with risk of coronary_artery_disease : a meta-analysis .
17870167	0	peroxisome_proliferator-activated_receptor_gamma	106,154	Pigment_epithelium-derived_factor	0,33	peroxisome proliferator-activated receptor gamma	Pigment epithelium-derived factor	5468	57104	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	Pigment_epithelium-derived_factor induces THP-1 macrophage apoptosis and necrosis by the induction of the peroxisome_proliferator-activated_receptor_gamma .
19996102	0	peroxisome_proliferator-activated_receptor_gamma	43,91	Pin1	28,32	peroxisome proliferator-activated receptor gamma	Pin1	5468	5300	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Proline cis/trans-isomerase Pin1 regulates peroxisome_proliferator-activated_receptor_gamma activity through the direct binding to the activation function-1 domain .
14656714	0	peroxisome_proliferator-activated_receptor_gamma	37,85	Tumor_necrosis_factor-alpha	0,27	peroxisome proliferator-activated receptor gamma	Tumor necrosis factor-alpha	5468	7124	Gene	Gene	activity|amod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha inhibits peroxisome_proliferator-activated_receptor_gamma activity at a posttranslational level in hepatic stellate cells .
19321447	0	peroxisome_proliferator-activated_receptor_gamma	65,113	Tumor_necrosis_factor-alpha	0,27	peroxisome proliferator-activated receptor gamma	Tumor necrosis factor-alpha	5468	7124	Gene	Gene	cleavage|nmod|START_ENTITY induces|dobj|cleavage induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces caspase-mediated cleavage of peroxisome_proliferator-activated_receptor_gamma in adipocytes .
20608974	0	peroxisome_proliferator-activated_receptor_gamma	23,71	Visfatin	0,8	peroxisome proliferator-activated receptor gamma	Visfatin	5468	10135	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Visfatin is induced by peroxisome_proliferator-activated_receptor_gamma in human macrophages .
16508313	0	peroxisome_proliferator-activated_receptor_gamma	37,85	insulin	115,122	peroxisome proliferator-activated receptor gamma	insulin	25664(Tax:10116)	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|resistance resistance|compound|END_ENTITY	Effect of aging on the expression of peroxisome_proliferator-activated_receptor_gamma and the possible relation to insulin resistance .
15041706	0	peroxisome_proliferator-activated_receptor_gamma	40,88	p21	17,20	peroxisome proliferator-activated receptor gamma	p21	5468	644914	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Up-regulation of p21 gene expression by peroxisome_proliferator-activated_receptor_gamma in human lung_carcinoma cells .
12663371	0	peroxisome_proliferator-activated_receptor_gamma-2	40,90	PPARG2	92,98	peroxisome proliferator-activated receptor gamma-2	PPARG2	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alanine for proline substitution in the peroxisome_proliferator-activated_receptor_gamma-2 -LRB- PPARG2 -RRB- gene and the risk of incident myocardial_infarction .
23300871	0	peroxisome_proliferator-activated_receptor_gamma-2	33,83	PPARy2	90,96	peroxisome proliferator-activated receptor gamma-2	PPARy2	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Pro12Ala polymorphism in the peroxisome_proliferator-activated_receptor_gamma-2 gene -LRB- PPARy2 -RRB- is associated with increased risk of coronary_artery_disease : a meta-analysis .
15284209	0	peroxisome_proliferator-activated_receptor_gamma2	29,78	tumor_necrosis_factor_alpha	98,125	peroxisome proliferator-activated receptor gamma2	tumor necrosis factor alpha	19016(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcription suppression of peroxisome_proliferator-activated_receptor_gamma2 gene expression by tumor_necrosis_factor_alpha via an inhibition of CCAAT / enhancer-binding protein delta during the early stage of adipocyte differentiation .
16759305	0	peroxisome_proliferator-activated_receptor_gamma_co-activator_1beta	24,91	PPARGC1B	93,101	peroxisome proliferator-activated receptor gamma co-activator 1beta	PPARGC1B	133522	133522	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Putative association of peroxisome_proliferator-activated_receptor_gamma_co-activator_1beta -LRB- PPARGC1B -RRB- polymorphism with Type_2_diabetes_mellitus .
17479445	0	peroxisome_proliferator-activated_receptor_gamma_coactivator-1_alpha	4,72	PGC-1alpha	79,89	peroxisome proliferator-activated receptor gamma coactivator-1 alpha	PGC-1alpha	10891	10891	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The peroxisome_proliferator-activated_receptor_gamma_coactivator-1_alpha gene -LRB- PGC-1alpha -RRB- is not associated with type_2_diabetes_mellitus or body mass index among Hispanic and non Hispanic Whites from Colorado .
20438809	0	peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	71,138	AMP-activated_protein_kinase	0,28	peroxisome proliferator-activated receptor gamma coactivator-1alpha	AMP-activated protein kinase	83516(Tax:10116)	78975(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression mediates|dobj|regulation mediates|nsubj|END_ENTITY	AMP-activated_protein_kinase mediates activity-dependent regulation of peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha and nuclear_respiratory_factor_1 expression in rat visual cortical neurons .
12777397	0	peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	18,85	GLUT4	101,106	peroxisome proliferator-activated receptor gamma coactivator-1alpha	GLUT4	10891	6517	Gene	Gene	down-regulates|amod|START_ENTITY Overexpression|nmod|down-regulates END_ENTITY|nsubj|Overexpression	Overexpression of peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles .
15649578	0	peroxisome_proliferator-activated_receptor_gamma_coactivator_1alpha	45,112	PGC-1alpha	114,124	peroxisome proliferator-activated receptor gamma coactivator 1alpha	PGC-1alpha	10891	10891	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Studies of the Gly482Ser polymorphism of the peroxisome_proliferator-activated_receptor_gamma_coactivator_1alpha -LRB- PGC-1alpha -RRB- gene in Danish subjects with the metabolic_syndrome .
12734177	0	peroxisome_proliferator-activated_receptor_gamma_coactivators_1alpha_and_1beta	25,103	PGC-1alpha	105,115	peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta	PGC-1alpha	10891;133522	10891	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Bioenergetic analysis of peroxisome_proliferator-activated_receptor_gamma_coactivators_1alpha_and_1beta -LRB- PGC-1alpha and PGC-1beta -RRB- in muscle cells .
25547017	0	peroxisome_proliferator-activated_receptor_y	58,102	MicroRNA-130b	0,13	peroxisome proliferator-activated receptor y	MicroRNA-130b	5468	406920	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	MicroRNA-130b regulates scleroderma fibrosis by targeting peroxisome_proliferator-activated_receptor_y .
21104228	0	peroxisome_proliferator-activated_receptor_y	21,65	PPARy	67,72	peroxisome proliferator-activated receptor y	PPARy	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- gene are associated with osteoporosis .
23826177	0	peroxisome_proliferator-activated_receptor_y	42,86	PPARy	88,93	peroxisome proliferator-activated receptor y	PPARy	5468	5468	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Ligand binding reduces SUMOylation of the peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- activation function 1 -LRB- AF1 -RRB- domain .
24072712	0	peroxisome_proliferator-activated_receptor_y	69,113	PPARy	115,120	peroxisome proliferator-activated receptor y	PPARy	5468	5468	Gene	Gene	stability|amod|START_ENTITY stability|appos|END_ENTITY	Herpesvirus-associated_ubiquitin-specific_protease -LRB- HAUSP -RRB- modulates peroxisome_proliferator-activated_receptor_y -LRB- PPARy -RRB- stability through its deubiquitinating activity .
20853849	0	peroxisome_proliferator-activated_receptor_y	26,70	Serum_amyloid_A	0,15	peroxisome proliferator-activated receptor y	Serum amyloid A	5468	6287	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Serum_amyloid_A activates peroxisome_proliferator-activated_receptor_y through extracellularly regulated kinase 1/2 and COX-2 expression in hepatocytes .
25223794	0	peroxisome_proliferator-activated_receptor_y2	52,97	X-box_binding_protein_1	0,23	peroxisome proliferator-activated receptor y2	X-box binding protein 1	5468	7494	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	X-box_binding_protein_1 is a novel key regulator of peroxisome_proliferator-activated_receptor_y2 .
11007963	0	peroxisome_proliferator-activated_receptors	12,55	PPAR	57,61	peroxisome proliferator-activated receptors	PPAR	5465	5465	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the peroxisome_proliferator-activated_receptors -LRB- PPAR -RRB- in atherosclerosis .
24758429	0	peroxisome_proliferator-activated_receptors	36,79	PPAR	30,34	peroxisome proliferator-activated receptors	PPAR	5465	5465	Gene	Gene	synthesis|appos|START_ENTITY synthesis|nmod|END_ENTITY	Enantioselective synthesis of PPAR -LRB- peroxisome_proliferator-activated_receptors -RRB- agonists and antagonists .
14521714	0	peroxisome_proliferator_activated_receptor	37,79	PPAR	81,85	peroxisome proliferator activated receptor	PPAR	5465	5465	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Gamma -LRB- gamma -RRB- tocopherol upregulates peroxisome_proliferator_activated_receptor -LRB- PPAR -RRB- gamma -LRB- gamma -RRB- expression in SW 480 human colon_cancer cell lines .
16912428	0	peroxisome_proliferator_activated_receptor	10,52	PPAR	54,58	peroxisome proliferator activated receptor	PPAR	25747(Tax:10116)	25747(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of peroxisome_proliferator_activated_receptor -LRB- PPAR -RRB- gamma agonists on prostaglandins cascade in joint cells .
23921352	0	peroxisome_proliferator_activated_receptor	51,93	PPAR	95,99	peroxisome proliferator activated receptor	PPAR	5465	5465	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The effect of embryo presence on the expression of peroxisome_proliferator_activated_receptor -LRB- PPAR -RRB- genes in the porcine reproductive system during periimplantation .
9168928	0	peroxisome_proliferator_activated_receptor-gamma	68,116	hPPAR_gamma	118,129	peroxisome proliferator activated receptor-gamma	hPPAR gamma	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization and partial genomic structure of the human peroxisome_proliferator_activated_receptor-gamma -LRB- hPPAR_gamma -RRB- gene .
16338464	0	peroxisome_proliferator_activated_receptor-gamma	25,73	p38	11,14	peroxisome proliferator activated receptor-gamma	p38	5468	1432	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The kinase p38 regulates peroxisome_proliferator_activated_receptor-gamma in human trophoblasts .
17616429	0	peroxisome_proliferator_activated_receptor_alpha	29,77	Interleukin-6	0,13	peroxisome proliferator activated receptor alpha	Interleukin-6	5465	3569	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-6 inhibits human peroxisome_proliferator_activated_receptor_alpha gene expression via CCAAT/enhancer-binding proteins in hepatocytes .
18726867	0	peroxisome_proliferator_activated_receptor_alpha	30,78	PPARA	85,90	peroxisome proliferator activated receptor alpha	PPARA	5465	5465	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	The L162V polymorphism of the peroxisome_proliferator_activated_receptor_alpha gene -LRB- PPARA -RRB- is not associated with type 2 diabetes , BMI or body fat composition .
18853997	0	peroxisome_proliferator_activated_receptor_alpha	32,80	PPAR_alpha	82,92	peroxisome proliferator activated receptor alpha	PPAR alpha	5465	5465	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A Val227Ala substitution in the peroxisome_proliferator_activated_receptor_alpha -LRB- PPAR_alpha -RRB- gene associated with non-alcoholic_fatty_liver_disease and decreased waist circumference and waist-to-hip ratio .
18520060	0	peroxisome_proliferator_activated_receptor_alpha	45,93	SLC22A5	33,40	peroxisome proliferator activated receptor alpha	SLC22A5	25747(Tax:10116)	29726(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of Octn2 transporter -LRB- SLC22A5 -RRB- by peroxisome_proliferator_activated_receptor_alpha .
11409297	0	peroxisome_proliferator_activated_receptor_gamma	61,109	PPAR_gamma	111,121	peroxisome proliferator activated receptor gamma	PPAR gamma	5468	5468	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between the P12A and c1431t polymorphisms in the peroxisome_proliferator_activated_receptor_gamma -LRB- PPAR_gamma -RRB- gene and type 2 diabetes .
10762291	0	peroxisome_proliferator_activated_receptor_gamma	16,64	PPARgamma	66,75	peroxisome proliferator activated receptor gamma	PPARgamma	5468	5468	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the peroxisome_proliferator_activated_receptor_gamma -LRB- PPARgamma -RRB- gene in HAIRAN_syndrome with obesity .
15174093	0	peroxisome_proliferator_activated_receptor_gamma	24,72	cftr	76,80	peroxisome proliferator activated receptor gamma	cftr	19016(Tax:10090)	12638(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of peroxisome_proliferator_activated_receptor_gamma in cftr - / - mice .
9425261	0	peroxisome_proliferator_activated_receptor_gamma	32,80	hPPAR_gamma	82,93	peroxisome proliferator activated receptor gamma	hPPAR gamma	5468	5468	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Molecular scanning of the human peroxisome_proliferator_activated_receptor_gamma -LRB- hPPAR_gamma -RRB- gene in diabetic Caucasians : identification of a Pro12Ala PPAR_gamma 2 missense mutation .
10585775	0	peroxisome_proliferator_activated_receptor_gamma_coactivator_1	6,68	PPARGC1	70,77	peroxisome proliferator activated receptor gamma coactivator 1	PPARGC1	10891	10891	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human peroxisome_proliferator_activated_receptor_gamma_coactivator_1 -LRB- PPARGC1 -RRB- gene : cDNA sequence , genomic organization , chromosomal localization , and tissue expression .
22920733	0	peroxisome_proliferator_activator_receptor-a	75,119	PPARA	126,131	peroxisome proliferator activator receptor-a	PPARA	5465	5465	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of endocannabinoid system genes suggests association between peroxisome_proliferator_activator_receptor-a gene -LRB- PPARA -RRB- and schizophrenia .
2576634	0	pgm-1	58,63	D-amino-acid_oxidase	30,50	pgm-1	D-amino-acid oxidase	66681(Tax:10090)	13142(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|nmod|gene	Linkage of the Dao-1 gene for D-amino-acid_oxidase to the pgm-1 gene for phosphoglucomutase-1 on the mouse chromosome 5 .
2576634	0	pgm-1	58,63	phosphoglucomutase-1	73,93	pgm-1	phosphoglucomutase-1	66681(Tax:10090)	66681(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Linkage of the Dao-1 gene for D-amino-acid_oxidase to the pgm-1 gene for phosphoglucomutase-1 on the mouse chromosome 5 .
22115783	0	phafin1	23,30	Rab7	43,47	phafin1	Rab7	79156	338382	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Lysosomal targeting of phafin1 mediated by Rab7 induces autophagosome formation .
8661000	0	phenol_sulfotransferase	6,29	STP2	30,34	phenol sulfotransferase	STP2	6817	6799	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Human phenol_sulfotransferase STP2 gene : molecular cloning , structural characterization , and chromosomal localization .
6580988	0	phenol_sulfotransferase	9,32	catechol-O-methyltransferase	49,77	phenol sulfotransferase	catechol-O-methyltransferase	6817	1312	Gene	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	Platelet phenol_sulfotransferase and erythrocyte catechol-O-methyltransferase activities : correlation with methyldopa metabolism .
18801354	0	phenoloxidase	42,55	Serpin-28D	11,21	phenoloxidase	Serpin-28D	8680162	34091(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation .
24301035	0	phenylalanine_ammonia-lyase	18,45	PAL	47,50	phenylalanine ammonia-lyase	PAL	543380(Tax:4565)	543380(Tax:4565)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The estimation of phenylalanine_ammonia-lyase -LRB- PAL -RRB- activity in intact cells of higher plant tissue : III .
11139255	0	phenylalanine_hydroxylase	27,52	PAH	59,62	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ten novel mutations in the phenylalanine_hydroxylase gene -LRB- PAH -RRB- observed in Brazilian patients with phenylketonuria .
11180595	0	phenylalanine_hydroxylase	17,42	PAH	44,47	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene in Brazilian patients with phenylketonuria .
15730960	0	phenylalanine_hydroxylase	28,53	PAH	55,58	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Mutations in exon 7 of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene in chinese patients with phenylketonuria -RSB- .
16931086	0	phenylalanine_hydroxylase	62,87	PAH	89,92	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of large deletions in the phenylalanine_hydroxylase -LRB- PAH -RRB- gene by MLPA : evidence for both homologous and non-homologous mechanisms of rearrangement .
18294361	0	phenylalanine_hydroxylase	27,52	PAH	54,57	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A mutation analysis of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene in the Israeli population .
18299955	0	phenylalanine_hydroxylase	61,86	PAH	88,91	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotype-phenotype correlations analysis of mutations in the phenylalanine_hydroxylase -LRB- PAH -RRB- gene .
23898865	0	phenylalanine_hydroxylase	52,77	PAH	79,82	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible association between common variants of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene and memory performance in healthy adults .
24401910	0	phenylalanine_hydroxylase	29,54	PAH	56,59	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The mutation spectrum of the phenylalanine_hydroxylase -LRB- PAH -RRB- gene and associated haplotypes reveal ethnic heterogeneity in the Taiwanese population .
9781015	0	phenylalanine_hydroxylase	16,41	PAH	48,51	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation at the phenylalanine_hydroxylase gene -LRB- PAH -RRB- and its use to document population genetic variation : the Quebec experience .
9792411	0	phenylalanine_hydroxylase	121,146	PAH	153,156	phenylalanine hydroxylase	PAH	5053	5053	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Alterations in protein_aggregation and degradation due to mild and severe missense mutations -LRB- A104D , R157N -RRB- in the human phenylalanine_hydroxylase gene -LRB- PAH -RRB- .
1682495	0	phenylalanine_hydroxylase	24,49	aid	61,64	phenylalanine hydroxylase	aid	5053	57379	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Silent mutations in the phenylalanine_hydroxylase gene as an aid to the diagnosis of phenylketonuria .
7744747	0	phenylethanolamine_N-methyltransferase	60,98	Egr-1	29,34	phenylethanolamine N-methyltransferase	Egr-1	24661(Tax:10116)	24330(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of transcription factor Egr-1 in phorbol_ester-induced phenylethanolamine_N-methyltransferase gene expression .
1303174	0	phenylethanolamine_N-methyltransferase	38,76	PNMT	78,82	phenylethanolamine N-methyltransferase	PNMT	5409	5409	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Genetic linkage of the human gene for phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- , the adrenaline-synthesizing enzyme , to DNA markers on chromosome 17q21-q22 .
1358447	0	phenylethanolamine_N-methyltransferase	51,89	PNMT	91,95	phenylethanolamine N-methyltransferase	PNMT	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Glucocorticoids stimulate transcription of the rat phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- gene in vivo and in vitro .
17175506	0	phenylethanolamine_N-methyltransferase	53,91	PNMT	93,97	phenylethanolamine N-methyltransferase	PNMT	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Modulation by 6-hydroxydopamine of expression of the phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- gene in the rat heart during immobilization stress .
2816488	0	phenylethanolamine_N-methyltransferase	14,52	PNMT	54,58	phenylethanolamine N-methyltransferase	PNMT	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Regulation of phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- mRNA in the rat adrenal medulla by corticosterone .
3440206	0	phenylethanolamine_N-methyltransferase	26,64	PNMT	66,70	phenylethanolamine N-methyltransferase	PNMT	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Glucocorticoid effects on phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- in explants of embryonic_rat_medulla_oblongata .
6381173	0	phenylethanolamine_N-methyltransferase	29,67	PNMT	69,73	phenylethanolamine N-methyltransferase	PNMT	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Glucocorticoid regulation of phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- in organ culture of superior cervical ganglia .
8367022	0	phenylethanolamine_N-methyltransferase	26,64	PNMT	66,70	phenylethanolamine N-methyltransferase	PNMT	24661(Tax:10116)	24661(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Cold-induced increases in phenylethanolamine_N-methyltransferase -LRB- PNMT -RRB- mRNA are mediated by non-cholinergic mechanisms in the rat adrenal gland .
10933783	0	phenylpyruvate_tautomerase	17,43	macrophage_migration_inhibitory_factor	56,94	phenylpyruvate tautomerase	macrophage migration inhibitory factor	4282	4282	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Mechanism of the phenylpyruvate_tautomerase activity of macrophage_migration_inhibitory_factor : properties of the P1G , P1A , Y95F , and N97A mutants .
16780921	0	phenylpyruvate_tautomerase	20,46	macrophage_migration_inhibitory_factor	59,97	phenylpyruvate tautomerase	macrophage migration inhibitory factor	4282	4282	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Inactivation of the phenylpyruvate_tautomerase activity of macrophage_migration_inhibitory_factor by 2-oxo-4-phenyl-3-butynoate .
12145299	0	pho2	17,21	bas2	23,27	pho2	bas2	851452(Tax:4932)	851452(Tax:4932)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Mutations in the pho2 -LRB- bas2 -RRB- transcription factor that differentially affect activation with its partner proteins bas1 , pho4 , and swi5 .
12145299	0	pho4	120,124	bas1	114,118	pho4	bas1	850594(Tax:4932)	853974(Tax:4932)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Mutations in the pho2 -LRB- bas2 -RRB- transcription factor that differentially affect activation with its partner proteins bas1 , pho4 , and swi5 .
11872741	0	phocein	16,23	nucleoside-diphosphate_kinase	29,58	phocein	nucleoside-diphosphate kinase	171050(Tax:10116)	298410(Tax:10116)	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of phocein with nucleoside-diphosphate_kinase , Eps15 , and Dynamin_I .
8772720	0	phogrin	85,92	IDDM	40,44	phogrin	IDDM	5799	3630	Gene	Gene	protein|appos|START_ENTITY END_ENTITY|nmod|protein	Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein -LRB- phogrin -RRB- related to IA-2 .
10884381	0	phosducin	19,28	G_protein-coupled_receptor_kinase_2	59,94	phosducin	G protein-coupled receptor kinase 2	5132	156	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of phosducin and phosducin-like_protein by G_protein-coupled_receptor_kinase_2 .
8188267	0	phosducin	26,35	PDC	42,45	phosducin	PDC	5132	5132	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The sequence of the human phosducin gene -LRB- PDC -RRB- and its 5 ' - flanking region .
8288249	0	phosducin	18,27	PDC	29,32	phosducin	PDC	5132	5132	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the phosducin -LRB- PDC -RRB- gene to human chromosome 1q25-1q32 .1 by somatic cell hybridization and in situ hybridization .
8646891	0	phosducin	109,118	PDC	125,128	phosducin	PDC	5132	5132	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fine mapping of the autosomal_recessive_retinitis_pigmentosa locus -LRB- RP12 -RRB- on chromosome 1q ; exclusion of the phosducin gene -LRB- PDC -RRB- .
2394752	0	phosducin	40,49	Protein_kinase_A	0,16	phosducin	Protein kinase A	287007(Tax:9913)	25636(Tax:10116)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Protein_kinase_A phosphorylates retinal phosducin on serine 73 in situ .
10899582	0	phosducin-like_protein	52,74	hPhLP	76,81	phosducin-like protein	hPhLP	5132	5132	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Molecular cloning and characterization of the human phosducin-like_protein -LRB- hPhLP -RRB- promoter .
22174782	0	phosducin-like_protein_3	14,38	PhLP3	40,45	phosducin-like protein 3	PhLP3	79031	79031	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Modulation of phosducin-like_protein_3 -LRB- PhLP3 -RRB- levels promotes cytoskeletal remodelling in a MAPK and RhoA-dependent manner .
15226296	0	phosphatase-1	75,88	PP1	90,93	phosphatase-1	PP1	19047(Tax:10090)	19047(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
15226296	0	phosphatase-1	75,88	Spz1	48,52	phosphatase-1	Spz1	19047(Tax:10090)	79401(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|nmod|protein	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
12186863	0	phosphatase-2A	19,33	p38	37,40	phosphatase-2A	p38	5524	1432	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH -LRB- 2 -RRB- - terminal kinase pathway in human neutrophils .
12198769	0	phosphatase-2A	8,22	paxillin	76,84	phosphatase-2A	paxillin	5524	5829	Gene	Gene	modulates|nsubj|START_ENTITY modulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis_lung_carcinoma tumor variants .
10698523	0	phosphatase_2A	124,138	Axin	154,158	phosphatase 2A	Axin	5524	8312	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	GSK-3beta-dependent phosphorylation of adenomatous_polyposis_coli gene product can be modulated by beta-catenin and protein phosphatase_2A complexed with Axin .
10866685	0	phosphatase_2A	43,57	B56alpha	4,12	phosphatase 2A	B56alpha	5524	5525	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	The B56alpha regulatory subunit of protein phosphatase_2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR .
22583914	0	phosphatase_2A	38,52	Bb2	53,56	phosphatase 2A	Bb2	5524	2925	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|parataxis|regulates regulates|nsubj|END_ENTITY	N-terminal phosphorylation of protein phosphatase_2A / Bb2 regulates translocation to mitochondria , dynamin-related_protein_1 dephosphorylation , and neuronal survival .
15016329	0	phosphatase_2A	38,52	Bcl-2	21,26	phosphatase 2A	Bcl-2	5524	596	Gene	Gene	results|amod|START_ENTITY results|amod|END_ENTITY	Dephosphorylation of Bcl-2 by protein phosphatase_2A results in apoptosis resistance .
20160490	0	phosphatase_2A	48,62	CHK2	23,27	phosphatase 2A	CHK2	5524	11200	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	Negative regulation of CHK2 activity by protein phosphatase_2A is modulated by DNA damage .
22262175	0	phosphatase_2A	45,59	Cyclin_G-associated_kinase	0,26	phosphatase 2A	Cyclin G-associated kinase	5524	2580	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Cyclin_G-associated_kinase regulates protein phosphatase_2A by phosphorylation of its B ' y subunit .
12694872	0	phosphatase_2A	121,135	FHL2	63,67	phosphatase 2A	FHL2	5524	2274	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the coactivator four-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase_2A .
20404153	0	phosphatase_2A	80,94	Interleukin-23	0,14	phosphatase 2A	Interleukin-23	5524	27178	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|production production|amod|END_ENTITY	Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase_2A .
21044074	0	phosphatase_2A	22,36	LCMT1	52,57	phosphatase 2A	LCMT1	5524	51451	Gene	Gene	methylation|amod|START_ENTITY methylation|nmod|END_ENTITY	Regulation of protein phosphatase_2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells .
24928782	0	phosphatase_2A	24,38	PME-1	0,5	phosphatase 2A	PME-1	5524	51400	Gene	Gene	activity|amod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	PME-1 modulates protein phosphatase_2A activity to promote the malignant phenotype of endometrial_cancer cells .
24939844	0	phosphatase_2A	22,36	PP2A	38,42	phosphatase 2A	PP2A	5524	5524	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of protein phosphatase_2A -LRB- PP2A -RRB- prevents Mcl-1 protein dephosphorylation at the Thr-163 / Ser-159 phosphodegron , dramatically reducing expression in Mcl-1-amplified lymphoma cells .
11576548	0	phosphatase_2A	53,67	Src	14,17	phosphatase 2A	Src	5524	6714	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Src by direct interaction with protein phosphatase_2A .
25341065	0	phosphatase_2A	33,47	a1-Antitrypsin	0,14	phosphatase 2A	a1-Antitrypsin	5524	5265	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	a1-Antitrypsin activates protein phosphatase_2A to counter lung inflammatory responses .
18397887	0	phosphatase_2A	8,22	cell_division_control_protein_6	38,69	phosphatase 2A	cell division control protein 6	5524	990	Gene	Gene	targeted|nsubjpass|START_ENTITY targeted|nmod|END_ENTITY	Protein phosphatase_2A is targeted to cell_division_control_protein_6 by a calcium-binding regulatory subunit .
15364934	0	phosphatase_4	8,21	hematopoietic_progenitor_kinase_1	49,82	phosphatase 4	hematopoietic progenitor kinase 1	5531	11184	Gene	Gene	regulator|nsubj|START_ENTITY regulator|nmod|END_ENTITY	Protein phosphatase_4 is a positive regulator of hematopoietic_progenitor_kinase_1 .
19176521	0	phosphatase_5	8,21	53BP1	48,53	phosphatase 5	53BP1	5536	7158	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|function function|nmod|END_ENTITY	Protein phosphatase_5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage .
17079228	0	phosphatase_6	8,21	TAK1	37,41	phosphatase 6	TAK1	5537	6885	Gene	Gene	down-regulates|amod|START_ENTITY END_ENTITY|nsubj|down-regulates	Protein phosphatase_6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway .
9837938	0	phosphatase_X	8,21	c-Rel	37,42	phosphatase X	c-Rel	5531	5966	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Protein phosphatase_X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity .
26251180	0	phosphatase_and_tensin_homolog_deleted_on_chromosome_10	41,96	Focal_adhesion_kinase	0,21	phosphatase and tensin homolog deleted on chromosome 10	Focal adhesion kinase	19211(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Focal_adhesion_kinase phosphorylates the phosphatase_and_tensin_homolog_deleted_on_chromosome_10 under the control of p110 phosphoinositide-3 kinase .
26251180	0	phosphatase_and_tensin_homolog_deleted_on_chromosome_10	41,96	Focal_adhesion_kinase	0,21	phosphatase and tensin homolog deleted on chromosome 10	Focal adhesion kinase	19211(Tax:10090)	14083(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Focal_adhesion_kinase phosphorylates the phosphatase_and_tensin_homolog_deleted_on_chromosome_10 under the control of p110 phosphoinositide-3 kinase .
24929707	0	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	45,101	MiR-205	0,7	phosphatase and tensin homolog deleted on chromosome ten	MiR-205	5728	406988	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	MiR-205 inhibits cell apoptosis by targeting phosphatase_and_tensin_homolog_deleted_on_chromosome_ten in endometrial_cancer Ishikawa cells .
15849504	0	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	84,140	PTEN	78,82	phosphatase and tensin homolog deleted on chromosome ten	PTEN	5728	5728	Gene	Gene	down-regulation|appos|START_ENTITY down-regulation|nmod|END_ENTITY	Gastrin-releasing_peptide-induced down-regulation of tumor suppressor protein PTEN -LRB- phosphatase_and_tensin_homolog_deleted_on_chromosome_ten -RRB- in neuroblastomas .
16418168	0	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	23,79	PTEN	17,21	phosphatase and tensin homolog deleted on chromosome ten	PTEN	5728	5728	Gene	Gene	Up-regulation|appos|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of PTEN -LRB- phosphatase_and_tensin_homolog_deleted_on_chromosome_ten -RRB- mediates p38 MAPK stress signal-induced inhibition of insulin signaling .
25012292	0	phosphatase_and_tensin_homolog_deleted_on_chromosome_ten	19,75	PTEN	77,81	phosphatase and tensin homolog deleted on chromosome ten	PTEN	100156264(Tax:9823)	100156264(Tax:9823)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	The involvement of phosphatase_and_tensin_homolog_deleted_on_chromosome_ten -LRB- PTEN -RRB- in the regulation of inflammation following coronary microembolization .
21719054	0	phosphatase_and_tensin_homologue	33,65	Integrin-linked_kinase	0,22	phosphatase and tensin homologue	Integrin-linked kinase	5728	3611	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Integrin-linked_kinase regulates phosphatase_and_tensin_homologue activity to promote tumorigenesis in neuroblastoma cells .
23617834	0	phosphatase_and_tensin_homologue	31,63	MicroRNA-32	0,11	phosphatase and tensin homologue	MicroRNA-32	5728	407036	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-32 -LRB- miR-32 -RRB- regulates phosphatase_and_tensin_homologue -LRB- PTEN -RRB- expression and promotes growth , migration , and invasion in colorectal_carcinoma cells .
16107342	0	phosphatase_and_tensin_homologue	52,84	PTEN	86,90	phosphatase and tensin homologue	PTEN	5728	5728	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Cooperative phosphorylation of the tumor suppressor phosphatase_and_tensin_homologue -LRB- PTEN -RRB- by casein kinases and glycogen_synthase_kinase_3beta .
24588644	0	phosphatase_and_tensin_homologue	16,48	PTEN	50,54	phosphatase and tensin homologue	PTEN	5728	5728	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Interactions of phosphatase_and_tensin_homologue -LRB- PTEN -RRB- proteins with phosphatidylinositol_phosphates : insights from molecular dynamics simulations of PTEN and voltage sensitive phosphatase .
24830779	0	phosphatase_and_tensin_homologue	14,46	PTEN	48,52	phosphatase and tensin homologue	PTEN	5728	5728	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of phosphatase_and_tensin_homologue -LRB- PTEN -RRB- in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles .
17097286	0	phosphatase_and_tensin_homologue_deleted_on_chromosome_ten	25,83	PTEN	19,23	phosphatase and tensin homologue deleted on chromosome ten	PTEN	5728	5728	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Phosphorylation of PTEN -LRB- phosphatase_and_tensin_homologue_deleted_on_chromosome_ten -RRB- protein is enhanced in human fibromyomatous uteri .
20860603	0	phosphatase_of_regenerating_liver-3	15,50	nucleolin	85,94	phosphatase of regenerating liver-3	nucleolin	11156	4691	Gene	Gene	Requirement|nmod|START_ENTITY Requirement|nmod|END_ENTITY	Requirement of phosphatase_of_regenerating_liver-3 for the nucleolar localization of nucleolin during the progression of colorectal_carcinoma .
18253812	0	phosphatase_type_5	37,55	PP5	57,60	phosphatase type 5	PP5	5536	5536	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of serine/threonine protein phosphatase_type_5 -LRB- PP5 -RRB- in the regulation of stress-induced signaling networks and cancer .
17169329	0	phosphatidic_acid_phosphatase_2a	18,50	p73	120,123	phosphatidic acid phosphatase 2a	p73	8611	7161	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	The expression of phosphatidic_acid_phosphatase_2a , which hydrolyzes lipids to generate diacylglycerol , is regulated by p73 , a member of the p53 family .
20922461	0	phosphatidyl_inositol_3-kinase	4,34	AKT	35,38	phosphatidyl inositol 3-kinase	AKT	5293	207	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	The phosphatidyl_inositol_3-kinase / AKT signaling pathway in breast_cancer .
11420179	0	phosphatidylethanolamine_N-methyltransferase	70,114	PEMT	116,120	phosphatidylethanolamine N-methyltransferase	PEMT	10400	10400	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure , expression profile and alternative processing of the human phosphatidylethanolamine_N-methyltransferase -LRB- PEMT -RRB- gene .
24963152	0	phosphatidylethanolamine_N-methyltransferase	66,110	PEMT	112,116	phosphatidylethanolamine N-methyltransferase	PEMT	18618(Tax:10090)	18618(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Maternal_choline_supplementation programs greater activity of the phosphatidylethanolamine_N-methyltransferase -LRB- PEMT -RRB- pathway in adult Ts65Dn trisomic mice .
20150657	0	phosphatidylethanolamine_N-methyltransferase	48,92	Sp1	11,14	phosphatidylethanolamine N-methyltransferase	Sp1	18618(Tax:10090)	20683(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Sp1 in transcriptional regulation of phosphatidylethanolamine_N-methyltransferase in liver and 3T3-L1 adipocytes .
8738137	0	phosphatidylethanolamine_binding_protein	44,84	PBP	86,89	phosphatidylethanolamine binding protein	PBP	5037	5037	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Sequence analysis and immunolocalisation of phosphatidylethanolamine_binding_protein -LRB- PBP -RRB- in human brain tissue .
11739615	0	phosphatidylinositide_3-kinase	8,38	DARPP-32	84,92	phosphatidylinositide 3-kinase	DARPP-32	5293	84152	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Role of phosphatidylinositide_3-kinase in brain-derived_neurotrophic_factor-induced DARPP-32 expression in medium size spiny neurons in vitro .
23813545	0	phosphatidylinositide_3-kinase	25,55	PI3K	57,61	phosphatidylinositide 3-kinase	PI3K	5290	5290	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Molecular changes in the phosphatidylinositide_3-kinase -LRB- PI3K -RRB- pathway are common in gastric_cancer .
19117013	0	phosphatidylinositol-3-kinase	72,101	Akt	102,105	phosphatidylinositol-3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	activate|xcomp|START_ENTITY glycoprotein|acl:relcl|activate glycoprotein|parataxis|signaling signaling|nsubj|END_ENTITY	Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase / Akt signaling in skeletal muscle in a laminin-dependent manner .
24273605	0	phosphatidylinositol-3-kinase	79,108	Akt	109,112	phosphatidylinositol-3-kinase	Akt	5293	207	Gene	Gene	transduction|amod|START_ENTITY transduction|compound|END_ENTITY	Type II cGMP-dependent protein kinase inhibits epidermal growth factor-induced phosphatidylinositol-3-kinase / Akt signal transduction in gastric_cancer cells .
16882036	0	phosphatidylinositol-3-kinase	21,50	PI3K	52,56	phosphatidylinositol-3-kinase	PI3K	5293	5293	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Bivalent role of the phosphatidylinositol-3-kinase -LRB- PI3K -RRB- during influenza_virus_infection and host cell defence .
20797855	0	phosphatidylinositol-3-kinase	36,65	PI3K	67,71	phosphatidylinositol-3-kinase	PI3K	5293	5293	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
17426084	0	phosphatidylinositol-3-kinase	69,98	akt	99,102	phosphatidylinositol-3-kinase	akt	5290	207	Gene	Gene	/|amod|START_ENTITY genetic_alterations|nmod|/ prevalence|nmod|genetic_alterations END_ENTITY|nsubj|prevalence	High prevalence and mutual exclusivity of genetic_alterations in the phosphatidylinositol-3-kinase / akt pathway in thyroid_tumors .
20797855	0	phosphatidylinositol-3-kinase	36,65	mTOR	104,108	phosphatidylinositol-3-kinase	mTOR	5293	21977(Tax:10090)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
20797855	0	phosphatidylinositol-3-kinase	36,65	mammalian_target_of_rapamycin	73,102	phosphatidylinositol-3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	PKI-179 : an orally efficacious dual phosphatidylinositol-3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- inhibitor .
18653476	0	phosphatidylinositol-3-kinase	38,67	p110-alpha	16,26	phosphatidylinositol-3-kinase	p110-alpha	5290	5290	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport .
18542100	0	phosphatidylinositol-3-kinase-gamma	8,43	PI3Kgamma	45,54	phosphatidylinositol-3-kinase-gamma	PI3Kgamma	30955(Tax:10090)	30955(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of phosphatidylinositol-3-kinase-gamma -LRB- PI3Kgamma -RRB- - mediated pathway in 17beta-estradiol-induced killing of L. mexicana in macrophages from C57BL/6 mice .
16370391	0	phosphatidylinositol-3_kinase	14,43	Akt	44,47	phosphatidylinositol-3 kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Targeting the phosphatidylinositol-3_kinase / Akt pathway for the treatment of cancer .
18544676	0	phosphatidylinositol-3_kinase	91,120	Akt	121,124	phosphatidylinositol-3 kinase	Akt	85243(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathways|amod|START_ENTITY pathways|dep|END_ENTITY	Lithium protection of phencyclidine-induced neurotoxicity in developing brain : the role of phosphatidylinositol-3_kinase / Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways .
19065678	0	phosphatidylinositol-3_kinase	22,51	Akt	111,114	phosphatidylinositol-3 kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	size|amod|START_ENTITY size|amod|phosphoinositide-dependent_protein_kinase_1 phosphoinositide-dependent_protein_kinase_1|dep|modulate modulate|nsubj|END_ENTITY	The survival pathways phosphatidylinositol-3_kinase -LRB- PI3-K -RRB- / phosphoinositide-dependent_protein_kinase_1 -LRB- PDK1 -RRB- / Akt modulate liver_regeneration through hepatocyte size rather than proliferation .
20578891	0	phosphatidylinositol-3_kinase	27,56	Akt	57,60	phosphatidylinositol-3 kinase	Akt	5290	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Genetic alterations in the phosphatidylinositol-3_kinase / Akt pathway in thyroid_cancer .
24524196	0	phosphatidylinositol-3_kinase	69,98	Akt	99,102	phosphatidylinositol-3 kinase	Akt	5290	207	Gene	Gene	signals|amod|START_ENTITY signals|compound|END_ENTITY	Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3_kinase / Akt signals .
3042807	0	phosphatidylinositol-specific_phospholipase_C	69,114	carcinoembryonic_antigen	11,35	phosphatidylinositol-specific phospholipase C	carcinoembryonic antigen	23236	1084	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of carcinoembryonic_antigen from human colon_cancer cells by phosphatidylinositol-specific_phospholipase_C .
8215392	0	phosphatidylinositol-specific_phospholipase_C	62,107	carcinoembryonic_antigen	11,35	phosphatidylinositol-specific phospholipase C	carcinoembryonic antigen	23236	1084	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Release of carcinoembryonic_antigen from human tumor cells by phosphatidylinositol-specific_phospholipase_C : highly effective extraction and upregulation from LS-174T colonic_adenocarcinoma cells .
1688497	0	phosphatidylinositol-specific_phospholipase_C	61,106	membrane_inhibitor_of_reactive_lysis	12,48	phosphatidylinositol-specific phospholipase C	membrane inhibitor of reactive lysis	23236	966	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dep|effects	Erythrocyte membrane_inhibitor_of_reactive_lysis : effects of phosphatidylinositol-specific_phospholipase_C on the isolated and cell-associated protein .
11010972	0	phosphatidylinositol_3-Kinase	90,119	AKT	120,123	phosphatidylinositol 3-Kinase	AKT	5290	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol_3-Kinase / AKT pathway .
14668339	0	phosphatidylinositol_3-OH_kinase	53,85	Androgen_receptor	0,17	phosphatidylinositol 3-OH kinase	Androgen receptor	5295	367	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Androgen_receptor mediates non-genomic activation of phosphatidylinositol_3-OH_kinase in androgen-sensitive epithelial cells .
11034077	0	phosphatidylinositol_3-kinase	4,33	AKT	34,37	phosphatidylinositol 3-kinase	AKT	5293	207	Gene	Gene	transduction|amod|START_ENTITY transduction|compound|END_ENTITY	The phosphatidylinositol_3-kinase / AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel .
11118064	0	phosphatidylinositol_3-kinase	4,33	AKT	34,37	phosphatidylinositol 3-kinase	AKT	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The phosphatidylinositol_3-kinase / AKT kinase pathway in multiple_myeloma plasma cells : roles in cytokine-dependent survival and proliferative responses .
12869565	0	phosphatidylinositol_3-kinase	75,104	AKT	105,108	phosphatidylinositol 3-kinase	AKT	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	cascades|amod|START_ENTITY cascades|compound|END_ENTITY	Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol_3-kinase / AKT cascades .
16014629	0	phosphatidylinositol_3-kinase	20,49	AKT	50,53	phosphatidylinositol 3-kinase	AKT	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	activation|dep|START_ENTITY activation|compound|END_ENTITY	Presenilins mediate phosphatidylinositol_3-kinase / AKT and ERK activation via select signaling receptors .
16227402	0	phosphatidylinositol_3-kinase	177,206	AKT	54,57	phosphatidylinositol 3-kinase	AKT	5293	207	Gene	Gene	cascade|amod|START_ENTITY /|dobj|cascade up-regulating|xcomp|/ activate|advcl|up-regulating activate|dobj|kinase kinase|compound|END_ENTITY	Mammalian_target_of_rapamycin inhibitors activate the AKT kinase in multiple_myeloma cells by up-regulating the insulin-like growth factor receptor/insulin _ receptor_substrate-1 / phosphatidylinositol_3-kinase cascade .
18831514	0	phosphatidylinositol_3-kinase	69,98	AKT	99,102	phosphatidylinositol 3-kinase	AKT	5290	207	Gene	Gene	alterations|nmod|START_ENTITY Association|nmod|alterations Association|parataxis|signaling signaling|nsubj|END_ENTITY	Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol_3-kinase / AKT signaling pathway in thyroid_tumors .
20959404	0	phosphatidylinositol_3-kinase	73,102	AKT	103,106	phosphatidylinositol 3-kinase	AKT	5293	207	Gene	Gene	START_ENTITY|appos|confers confers|nsubj|END_ENTITY	cIAP2 upregulated by E6 oncoprotein via epidermal_growth_factor_receptor / phosphatidylinositol_3-kinase / AKT pathway confers resistance to cisplatin in human_papillomavirus_16 / 18-infected lung_cancer .
21042767	0	phosphatidylinositol_3-kinase	24,53	AKT	54,57	phosphatidylinositol 3-kinase	AKT	5293	207	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|parataxis|leads leads|nsubj|pathway pathway|compound|END_ENTITY	Inhibition of activated phosphatidylinositol_3-kinase / AKT pathway in malignant_pleural_mesothelioma leads to G1 cell cycle arrest .
24934342	0	phosphatidylinositol_3-kinase	14,43	AKT	44,47	phosphatidylinositol 3-kinase	AKT	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Targeting the phosphatidylinositol_3-kinase / AKT pathway for the treatment of multiple_myeloma .
25709476	0	phosphatidylinositol_3-kinase	60,89	AKT	90,93	phosphatidylinositol 3-kinase	AKT	5290	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Andrographolide inhibits hypoxia-inducible_factor-1 through phosphatidylinositol_3-kinase / AKT pathway and suppresses breast_cancer growth .
11067939	0	phosphatidylinositol_3-kinase	161,190	Akt	191,194	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	up-stream|amod|START_ENTITY up-stream|compound|END_ENTITY	Inhibition of TNF-alpha-induced neutrophil apoptosis by crystals of calcium_pyrophosphate_dihydrate is mediated by the extracellular signal-regulated kinase and phosphatidylinositol_3-kinase / Akt pathways up-stream of caspase_3 .
11278333	0	phosphatidylinositol_3-kinase	18,47	Akt	48,51	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Activation of the phosphatidylinositol_3-kinase / Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis .
11294857	0	phosphatidylinositol_3-kinase	38,67	Akt	68,71	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Hypoxia induces the activation of the phosphatidylinositol_3-kinase / Akt cell survival pathway in PC12 cells : protective role in apoptosis .
11356694	0	phosphatidylinositol_3-kinase	54,83	Akt	84,87	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	X-linked_inhibitor_of_apoptosis_protein activates the phosphatidylinositol_3-kinase / Akt pathway in rat granulosa cells during follicular development .
11368352	0	phosphatidylinositol_3-kinase	86,115	Akt	13,16	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	upstream|advcl|START_ENTITY occurs|advmod|upstream occurs|nsubj|Induction Induction|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol_3-kinase : no evidence for oxidative inhibition of PTEN .
11479306	0	phosphatidylinositol_3-kinase	62,91	Akt	92,95	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	Cyclic_AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol_3-kinase / Akt pathways by inhibiting Rap1 .
11585835	1	phosphatidylinositol_3-kinase	118,147	Akt	148,151	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Involvement of phosphatidylinositol_3-kinase / Akt pathway .
11593409	0	phosphatidylinositol_3-kinase	57,86	Akt	87,90	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	207	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol_3-kinase / Akt activation by growth factors .
12032135	0	phosphatidylinositol_3-kinase	23,52	Akt	53,56	phosphatidylinositol 3-kinase	Akt	5294	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Down-regulation of the phosphatidylinositol_3-kinase / Akt pathway is involved in retinoic_acid-induced phosphorylation , degradation , and transcriptional activity of retinoic_acid receptor gamma 2 .
12130673	0	phosphatidylinositol_3-kinase	99,128	Akt	129,132	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Insulin-like_growth_factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol_3-kinase / Akt kinase and role of this pathway in insulin-like_growth_factor-1-induced survival of cultured hippocampal neurons .
12446712	0	phosphatidylinositol_3-kinase	66,95	Akt	96,99	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	remodeling|amod|START_ENTITY remodeling|dep|END_ENTITY	Epstein-Barr_virus latent membrane protein 1 -LRB- LMP1 -RRB- activates the phosphatidylinositol_3-kinase / Akt pathway to promote cell survival and induce actin filament remodeling .
12591985	0	phosphatidylinositol_3-kinase	27,56	Akt	57,60	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of deguelin on the phosphatidylinositol_3-kinase / Akt pathway and apoptosis in premalignant human bronchial epithelial cells .
12624428	0	phosphatidylinositol_3-kinase	8,37	Akt	38,41	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Role of phosphatidylinositol_3-kinase / Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric_oxide synthase in vascular smooth muscle cells .
12637493	0	phosphatidylinositol_3-kinase	29,58	Akt	59,62	phosphatidylinositol 3-kinase	Akt	5295	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	CD40-dependent activation of phosphatidylinositol_3-kinase / Akt pathway mediates endothelial cell survival and in vitro angiogenesis .
12640124	0	phosphatidylinositol_3-kinase	35,64	Akt	65,68	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Caveolin-induced activation of the phosphatidylinositol_3-kinase / Akt pathway increases arsenite cytotoxicity .
12952968	0	phosphatidylinositol_3-kinase	84,113	Akt	114,117	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Epidermal_growth_factor_receptor-dependent , NF-kappaB-independent activation of the phosphatidylinositol_3-kinase / Akt pathway inhibits ultraviolet irradiation-induced caspases-3 , _ -8 , _ and _ -9 in human keratinocytes .
14555644	0	phosphatidylinositol_3-kinase	67,96	Akt	97,100	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Suppression versus induction of androgen_receptor functions by the phosphatidylinositol_3-kinase / Akt pathway in prostate_cancer LNCaP cells with different passage numbers .
14688281	0	phosphatidylinositol_3-kinase	54,83	Akt	84,87	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Regulation of heme_oxygenase-1 expression through the phosphatidylinositol_3-kinase / Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol .
15166238	0	phosphatidylinositol_3-kinase	37,66	Akt	67,70	phosphatidylinositol 3-kinase	Akt	5295	207	Gene	Gene	START_ENTITY|dep|I I|dep|END_ENTITY	Focal_adhesion_kinase is upstream of phosphatidylinositol_3-kinase / Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway .
15706421	0	phosphatidylinositol_3-kinase	15,44	Akt	45,48	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	Suppression|nmod|START_ENTITY Suppression|parataxis|determinant determinant|nsubj|signaling signaling|compound|END_ENTITY	Suppression of phosphatidylinositol_3-kinase / Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor , FK228 , in lung_adenocarcinoma cells .
15890643	0	phosphatidylinositol_3-kinase	216,245	Akt	247,250	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
15980035	0	phosphatidylinositol_3-kinase	55,84	Akt	85,88	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	p38 and EGF_receptor kinase-mediated activation of the phosphatidylinositol_3-kinase / Akt pathway is required for Zn2 + - induced cyclooxygenase-2 expression .
16061480	0	phosphatidylinositol_3-kinase	45,74	Akt	75,78	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	Induction|dep|START_ENTITY Induction|parataxis|substrate substrate|compound|END_ENTITY	Induction of androgen_receptor expression by phosphatidylinositol_3-kinase / Akt downstream substrate , FOXO3a , and their roles in apoptosis of LNCaP_prostate_cancer cells .
16115952	0	phosphatidylinositol_3-kinase	66,95	Akt	96,99	phosphatidylinositol 3-kinase	Akt	5295	207	Gene	Gene	inhibitors|nmod|START_ENTITY Response|nmod|inhibitors Response|dep|NH2-terminal NH2-terminal|amod|END_ENTITY	Response of non-small cell lung_cancer cells to the inhibitors of phosphatidylinositol_3-kinase / Akt - and MAPK kinase 4/c-Jun NH2-terminal kinase pathways : an effective therapeutic strategy for lung_cancer .
16155123	0	phosphatidylinositol_3-kinase	86,115	Akt	116,119	phosphatidylinositol 3-kinase	Akt	42446(Tax:7227)	41957(Tax:7227)	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol_3-kinase / Akt signaling .
16166311	0	phosphatidylinositol_3-kinase	18,47	Akt	48,51	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Inhibition of the phosphatidylinositol_3-kinase / Akt pathway by inositol_pentakisphosphate results in antiangiogenic and antitumor effects .
16546963	0	phosphatidylinositol_3-kinase	18,47	Akt	48,51	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Inhibition of the phosphatidylinositol_3-kinase / Akt pathway sensitizes MDA-MB468 human breast_cancer cells to cerulenin-induced apoptosis .
16650001	0	phosphatidylinositol_3-kinase	125,154	Akt	155,158	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol_3-kinase / Akt pathways .
16700876	0	phosphatidylinositol_3-kinase	93,122	Akt	123,126	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Hyperinsulinaemia increases the gene expression of endothelial nitric_oxide synthase and the phosphatidylinositol_3-kinase / Akt pathway in rat aorta .
16741926	0	phosphatidylinositol_3-kinase	14,43	Akt	51,54	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|amod|END_ENTITY	Regulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt and nuclear_factor-kappa_B signaling pathways in dystrophin-deficient_skeletal_muscle in response to mechanical stretch .
16924472	0	phosphatidylinositol_3-kinase	116,145	Akt	146,149	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via phosphatidylinositol_3-kinase / Akt pathway .
17170431	0	phosphatidylinositol_3-kinase	44,73	Akt	81,84	phosphatidylinositol 3-kinase	Akt	5295	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
17179158	0	phosphatidylinositol_3-kinase	45,74	Akt	85,88	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	signal|amod|START_ENTITY integrates|dobj|signal integrates|nmod|END_ENTITY	Statin-induced Ras activation integrates the phosphatidylinositol_3-kinase signal to Akt and MAPK for bone_morphogenetic_protein-2 expression in osteoblast differentiation .
17317825	0	phosphatidylinositol_3-kinase	50,79	Akt	80,83	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Genetic alterations and their relationship in the phosphatidylinositol_3-kinase / Akt pathway in thyroid_cancer .
17325368	0	phosphatidylinositol_3-kinase	14,43	Akt	44,47	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Effect of the phosphatidylinositol_3-kinase / Akt pathway on influenza_A_virus_propagation .
17640564	0	phosphatidylinositol_3-kinase	57,86	Akt	87,90	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	mediated|advcl|START_ENTITY Up-regulation|acl|mediated Up-regulation|parataxis|involved involved|nsubjpass|END_ENTITY	Up-regulation of aldose reductase expression mediated by phosphatidylinositol_3-kinase / Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage .
17896924	0	phosphatidylinositol_3-kinase	49,78	Akt	79,82	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Cross-talk between the androgen_receptor and the phosphatidylinositol_3-kinase / Akt pathway in prostate_cancer .
18198183	0	phosphatidylinositol_3-kinase	52,81	Akt	82,85	phosphatidylinositol 3-kinase	Akt	373752(Tax:8355)	399170(Tax:8355)	Gene	Gene	signal|amod|START_ENTITY signal|compound|END_ENTITY	Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol_3-kinase / Akt -LRB- PI3K/Akt -RRB- signal .
18216097	0	phosphatidylinositol_3-kinase	6,35	Akt	36,39	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|limits limits|nsubj|activation activation|compound|END_ENTITY	Early phosphatidylinositol_3-kinase / Akt pathway activation limits poliovirus-induced JNK-mediated cell death .
18243161	0	phosphatidylinositol_3-kinase	4,33	Akt	34,37	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The phosphatidylinositol_3-kinase / Akt pathway negatively regulates Nod2-mediated NF-kappaB pathway .
18332138	0	phosphatidylinositol_3-kinase	68,97	Akt	98,101	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	START_ENTITY|parataxis|signaling-dependent signaling-dependent|dep|END_ENTITY	Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol_3-kinase / Akt signaling-dependent .
18400376	0	phosphatidylinositol_3-kinase	102,131	Akt	132,135	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	intracellular|amod|START_ENTITY intracellular|compound|END_ENTITY	The release of fibroblast_growth_factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol_3-kinase / Akt intracellular signaling pathway .
18583416	0	phosphatidylinositol_3-kinase	70,99	Akt	100,103	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Modulation of caveolin-1 expression can affect signalling through the phosphatidylinositol_3-kinase / Akt pathway and cellular proliferation in response to insulin-like growth factor I .
19139118	0	phosphatidylinositol_3-kinase	16,45	Akt	46,49	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	Synergy|dep|START_ENTITY END_ENTITY|dep|Synergy	Synergy between phosphatidylinositol_3-kinase / Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung .
19458286	0	phosphatidylinositol_3-kinase	173,202	Akt	203,206	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	-LRB- S -RRB- -1 - -LRB- alpha-naphthylmethyl -RRB- -6,7 - dihydroxy-1 ,2,3,4 - tetrahydroisoquinoline -LRB- CKD712 -RRB- reduces rat myocardial apoptosis against ischemia and reperfusion injury by activation of phosphatidylinositol_3-kinase / Akt signaling and anti-inflammatory action in vivo .
19464003	0	phosphatidylinositol_3-kinase	19,48	Akt	49,52	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	related|advcl|START_ENTITY signaling|dep|related signaling|compound|END_ENTITY	Changes related to phosphatidylinositol_3-kinase / Akt signaling in leiomyomas : possible involvement of glycogen_synthase_kinase_3alpha and cyclin_D2 in the pathophysiology .
19584267	0	phosphatidylinositol_3-kinase	117,146	Akt	147,150	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Parathyroid_hormone-related_protein regulates cell survival pathways via integrin alpha6beta4-mediated activation of phosphatidylinositol_3-kinase / Akt signaling .
19661335	0	phosphatidylinositol_3-kinase	112,141	Akt	149,152	phosphatidylinositol 3-kinase	Akt	5290	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
20028853	0	phosphatidylinositol_3-kinase	29,58	Akt	59,62	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|parataxis|inhibit inhibit|nsubj|signaling signaling|compound|END_ENTITY	Small-molecule inhibitors of phosphatidylinositol_3-kinase / Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth .
20388520	0	phosphatidylinositol_3-kinase	115,144	Akt	145,148	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	mechanism|amod|START_ENTITY mechanism|dep|END_ENTITY	Inflammation and apoptosis in aortic tissues of aged type_II_diabetes : amelioration with alpha-lipoic_acid through phosphatidylinositol_3-kinase / Akt - dependent mechanism .
20406854	0	phosphatidylinositol_3-kinase	174,203	Akt	204,207	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	The farnesyltransferase inhibitor LB42708 suppresses vascular_endothelial_growth_factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol_3-kinase / Akt signal pathways .
20452332	0	phosphatidylinositol_3-kinase	82,111	Akt	112,115	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Meloxicam protects cell damage from 1-methyl-4-phenyl_pyridinium toxicity via the phosphatidylinositol_3-kinase / Akt pathway in human dopaminergic neuroblastoma SH-SY5Y cells .
20584208	0	phosphatidylinositol_3-kinase	37,66	Akt	67,70	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	Effects induced by inhibitors of the phosphatidylinositol_3-kinase / Akt and nitric_oxide synthase/guanylyl cyclase pathways on the isometric contraction in rat aorta : a comparative study .
21205925	0	phosphatidylinositol_3-kinase	14,43	Akt	44,47	phosphatidylinositol 3-kinase	Akt	5295	207	Gene	Gene	mediates|amod|START_ENTITY mediates|compound|END_ENTITY	Activation of phosphatidylinositol_3-kinase / Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular_carcinoma cells .
21618507	0	phosphatidylinositol_3-kinase	19,48	Akt	49,52	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|parataxis|signaling signaling|nsubj|END_ENTITY	Dual inhibition of phosphatidylinositol_3-kinase / Akt and mammalian_target_of_rapamycin signaling in human nonsmall cell lung_cancer cells by a dietary flavonoid_fisetin .
21908616	0	phosphatidylinositol_3-kinase	43,72	Akt	24,27	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	PDK1/mTORC2|amod|START_ENTITY independent|nmod|PDK1/mTORC2 sustain|dep|independent sustain|nsubj|END_ENTITY	IKBKE protein activates Akt independent of phosphatidylinositol_3-kinase / PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation .
22819846	0	phosphatidylinositol_3-kinase	113,142	Akt	143,146	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Hepatoma-derived_growth_factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of phosphatidylinositol_3-kinase / Akt pathway .
23123465	0	phosphatidylinositol_3-kinase	15,44	Akt	45,48	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Involvement of phosphatidylinositol_3-kinase / Akt pathway in gemcitabine-induced apoptosis-like cell death_in_insulinoma cell line INS-1 .
23192871	0	phosphatidylinositol_3-kinase	51,80	Akt	81,84	phosphatidylinositol 3-kinase	Akt	5295	207	Gene	Gene	progression|amod|START_ENTITY progression|dep|END_ENTITY	Varicella-zoster_virus ORF12 protein activates the phosphatidylinositol_3-kinase / Akt pathway to regulate cell cycle progression .
23426129	0	phosphatidylinositol_3-kinase	72,101	Akt	102,105	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Sulforaphane prevents human platelet_aggregation through inhibiting the phosphatidylinositol_3-kinase / Akt pathway .
23687303	0	phosphatidylinositol_3-kinase	9,38	Akt	46,49	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	Enhanced|dep|START_ENTITY Enhanced|parataxis|has has|nsubj|signaling signaling|compound|END_ENTITY	Enhanced phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress .
24080365	0	phosphatidylinositol_3-kinase	136,165	Akt	239,242	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	/|amod|START_ENTITY /|nmod|END_ENTITY	Insulin-like_growth_factor-1_receptor-mediated inhibition of A-type K -LRB- + -RRB- current induces sensory neuronal_hyperexcitability through the phosphatidylinositol_3-kinase and extracellular_signal-regulated_kinase_1 / 2 pathways , independently of Akt .
24338479	0	phosphatidylinositol_3-kinase	24,53	Akt	61,64	phosphatidylinositol 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	Manipulation|nmod|START_ENTITY Manipulation|parataxis|regulates regulates|nsubj|signaling signaling|compound|END_ENTITY	Manipulation of cardiac phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling by apoptosis_regulator_through_modulating_IAP_expression -LRB- ARIA -RRB- regulates cardiomyocyte_death during doxorubicin-induced cardiomyopathy .
24566006	0	phosphatidylinositol_3-kinase	120,149	Akt	150,153	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Anti-amyloidogenic effects of ID1201 , the ethanolic extract of the fruits of Melia toosendan , through activation of the phosphatidylinositol_3-kinase / Akt pathway .
25070581	0	phosphatidylinositol_3-kinase	14,43	Akt	44,47	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	Activation|nmod|START_ENTITY Activation|parataxis|mediates mediates|nsubj|signaling signaling|compound|END_ENTITY	Activation of phosphatidylinositol_3-kinase / Akt signaling mediates sorafenib-induced invasion and metastasis in hepatocellular_carcinoma .
26115885	0	phosphatidylinositol_3-kinase	88,117	Akt	143,146	phosphatidylinositol 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	/|amod|START_ENTITY B|compound|/ B|appos|END_ENTITY	Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / protein kinase B -LRB- Akt -RRB- signaling pathway .
26640543	0	phosphatidylinositol_3-kinase	94,123	Akt	124,127	phosphatidylinositol 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Inhibition of focal_adhesion_kinase induces apoptosis in bladder_cancer cells via Src and the phosphatidylinositol_3-kinase / Akt pathway .
24469394	0	phosphatidylinositol_3-kinase	20,49	Akt1	50,54	phosphatidylinositol 3-kinase	Akt1	5290	207	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Stat5 regulates the phosphatidylinositol_3-kinase / Akt1 pathway during mammary gland development and tumorigenesis .
25253337	0	phosphatidylinositol_3-kinase	29,58	Dlg1	10,14	phosphatidylinositol 3-kinase	Dlg1	5293	1739	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Hijacking Dlg1 for oncogenic phosphatidylinositol_3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins .
11535584	0	phosphatidylinositol_3-kinase	55,84	ERK	134,137	phosphatidylinositol 3-kinase	ERK	5290	2048	Gene	Gene	activities|amod|START_ENTITY exert|nsubj|activities exert|dobj|effects effects|nmod|pathway pathway|compound|END_ENTITY	Glial_cell_line-derived_neurotrophic_factor-stimulated phosphatidylinositol_3-kinase and Akt activities exert opposing effects on the ERK pathway : importance for the rescue of neuroectodermic cells .
19143758	0	phosphatidylinositol_3-kinase	119,148	ERK	51,54	phosphatidylinositol 3-kinase	ERK	5295	5594	Gene	Gene	inhibition|nmod|START_ENTITY lines|nmod|inhibition inhibits|nmod|lines inhibits|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	TGFbeta inhibits GM-CSF-induced phosphorylation of ERK and MEK in human myeloid_leukaemia cell lines via inhibition of phosphatidylinositol_3-kinase -LRB- PI3-k -RRB- .
15100294	0	phosphatidylinositol_3-kinase	58,87	Forkhead_box_O_3a	22,39	phosphatidylinositol 3-kinase	Forkhead box O 3a	18708(Tax:10090)	56484(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Reciprocal control of Forkhead_box_O_3a and c-Myc via the phosphatidylinositol_3-kinase pathway coordinately regulates p27Kip1 levels .
12704201	0	phosphatidylinositol_3-kinase	40,69	G_alpha_q	10,19	phosphatidylinositol 3-kinase	G alpha q	5295	2776	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Activated G_alpha_q inhibits p110 alpha phosphatidylinositol_3-kinase and Akt .
20018857	0	phosphatidylinositol_3-kinase	65,94	JNK1	131,135	phosphatidylinositol 3-kinase	JNK1	5293	5599	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol_3-kinase - and focal adhesion kinase-mediated JNK1 activation .
12209631	0	phosphatidylinositol_3-kinase	115,144	LAT	106,109	phosphatidylinositol 3-kinase	LAT	5294	27040	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	Lipid rafts as the signaling scaffold for NK cell activation : tyrosine phosphorylation and association of LAT with phosphatidylinositol_3-kinase and phospholipase C-gamma following CD2 stimulation .
15890643	0	phosphatidylinositol_3-kinase	216,245	MyD88	108,113	phosphatidylinositol 3-kinase	MyD88	298947(Tax:10116)	301059(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY expression|dep|factor expression|nmod|cells cells|nmod|receptor-associated receptor-associated|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
16644730	0	phosphatidylinositol_3-kinase	17,46	MyD88	8,13	phosphatidylinositol 3-kinase	MyD88	5293	4615	Gene	Gene	activation|amod|START_ENTITY END_ENTITY|nmod|activation	Role of MyD88 in phosphatidylinositol_3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells .
12533781	0	phosphatidylinositol_3-kinase	12,41	PI3K	43,47	phosphatidylinositol 3-kinase	PI3K	5293	5293	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- in CO2 stimulation of the Na + / HCO3 - _ cotransporter -LRB- NBC -RRB- .
16741926	0	phosphatidylinositol_3-kinase	14,43	PI3K	45,49	phosphatidylinositol 3-kinase	PI3K	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Regulation of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt and nuclear_factor-kappa_B signaling pathways in dystrophin-deficient_skeletal_muscle in response to mechanical stretch .
19661335	0	phosphatidylinositol_3-kinase	112,141	PI3K	143,147	phosphatidylinositol 3-kinase	PI3K	5290	5290	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Keratinocyte_growth_factor -LRB- KGF -RRB- regulates estrogen_receptor-alpha -LRB- ER-alpha -RRB- expression and cell apoptosis via phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway in human breast_cancer cells .
19919182	0	phosphatidylinositol_3-kinase	26,55	PI3K	57,61	phosphatidylinositol 3-kinase	PI3K	5293	5293	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Structural studies of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- SH3 domain in complex with a peptide ligand : role of the anchor residue in ligand binding .
21723579	0	phosphatidylinositol_3-kinase	46,75	PI3K	77,81	phosphatidylinositol 3-kinase	PI3K	5295	5295	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Infectious_bursal_disease_virus activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt signaling pathway by interaction of VP5 protein with the p85a subunit of PI3K .
21903247	0	phosphatidylinositol_3-kinase	16,45	PI3K	47,51	phosphatidylinositol 3-kinase	PI3K	5290	5290	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The role of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- pathway in the development and treatment of uterine cancer .
22929971	0	phosphatidylinositol_3-kinase	16,45	PI3K	47,51	phosphatidylinositol 3-kinase	PI3K	5290	5290	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	HS-173 , a novel phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis .
24361696	0	phosphatidylinositol_3-kinase	21,50	PI3K	52,56	phosphatidylinositol 3-kinase	PI3K	5293	5293	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	DW09849 , a selective phosphatidylinositol_3-kinase -LRB- PI3K -RRB- inhibitor , prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic mutation p110a -LRB- H1047R -RRB- .
20339116	0	phosphatidylinositol_3-kinase	66,95	Rac1	109,113	phosphatidylinositol 3-kinase	Rac1	298947(Tax:10116)	363875(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Insulin stabilizes microvascular endothelial barrier function via phosphatidylinositol_3-kinase / Akt-mediated Rac1 activation .
17698586	0	phosphatidylinositol_3-kinase	23,52	Reelin	0,6	phosphatidylinositol 3-kinase	Reelin	5293	5649	Gene	Gene	signals|nmod|START_ENTITY signals|nsubj|END_ENTITY	Reelin signals through phosphatidylinositol_3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth .
10488096	0	phosphatidylinositol_3-kinase	28,57	SHP-1	0,5	phosphatidylinositol 3-kinase	SHP-1	5295	5777	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	SHP-1 regulates Lck-induced phosphatidylinositol_3-kinase phosphorylation and activity .
10820390	0	phosphatidylinositol_3-kinase	38,67	STAT4	28,33	phosphatidylinositol 3-kinase	STAT4	5293	6775	Gene	Gene	pathways|amod|START_ENTITY END_ENTITY|nmod|pathways	IL-12 selectively regulates STAT4 via phosphatidylinositol_3-kinase and Ras-independent signal transduction pathways .
16288034	0	phosphatidylinositol_3-kinase	46,75	Smad2	94,99	phosphatidylinositol 3-kinase	Smad2	5293	4087	Gene	Gene	activation|nmod|START_ENTITY independent|nsubj|activation independent|nmod|END_ENTITY	Transforming_growth_factor-beta activation of phosphatidylinositol_3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated_kinase-2 .
16288034	0	phosphatidylinositol_3-kinase	46,75	Transforming_growth_factor-beta	0,31	phosphatidylinositol 3-kinase	Transforming growth factor-beta	5293	7040	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Transforming_growth_factor-beta activation of phosphatidylinositol_3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated_kinase-2 .
18358617	0	phosphatidylinositol_3-kinase	22,51	akt	52,55	phosphatidylinositol 3-kinase	akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	/|amod|START_ENTITY roles|nmod|/ END_ENTITY|nsubj|roles	Differential roles of phosphatidylinositol_3-kinase / akt pathway in retinal ganglion cell survival in rats with or without acute_ocular_hypertension .
19068483	0	phosphatidylinositol_3-kinase	4,33	akt	34,37	phosphatidylinositol 3-kinase	akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	cassette|amod|START_ENTITY cassette|compound|END_ENTITY	The phosphatidylinositol_3-kinase / akt cassette regulates purine nucleotide synthesis .
25824462	0	phosphatidylinositol_3-kinase	10,39	akt	40,43	phosphatidylinositol 3-kinase	akt	85243(Tax:10116)	24185(Tax:10116)	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	Activated phosphatidylinositol_3-kinase / akt inhibits the transition of endothelial progenitor cells to mesenchymal cells by regulating the forkhead box subgroup o-3a signaling .
15190125	0	phosphatidylinositol_3-kinase	95,124	bad	87,90	phosphatidylinositol 3-kinase	bad	298947(Tax:10116)	64639(Tax:10116)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	The bile_acid tauroursodeoxycholic_acid modulates phosphorylation and translocation of bad via phosphatidylinositol_3-kinase in glutamate-induced apoptosis of rat cortical neurons .
8557753	0	phosphatidylinositol_3-kinase	11,40	beta_1_integrin	62,77	phosphatidylinositol 3-kinase	beta 1 integrin	5293	3688	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|activity activity|amod|END_ENTITY	A role for phosphatidylinositol_3-kinase in the regulation of beta_1_integrin activity by the CD2 antigen .
15890643	0	phosphatidylinositol_3-kinase	216,245	c-Jun_N-terminal_kinase	252,275	phosphatidylinositol 3-kinase	c-Jun N-terminal kinase	298947(Tax:10116)	116554(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
15890643	0	phosphatidylinositol_3-kinase	216,245	c-Src	209,214	phosphatidylinositol 3-kinase	c-Src	298947(Tax:10116)	83805(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|amod|END_ENTITY	The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88 , interleukin-1 receptor-associated kinase , tumor necrosis factor receptor-associated factor 6 , c-Src , phosphatidylinositol_3-kinase , Akt , c-Jun_N-terminal_kinase , and activator_protein-1 signaling .
17991742	0	phosphatidylinositol_3-kinase	85,114	c-Src	0,5	phosphatidylinositol 3-kinase	c-Src	5293	6714	Gene	Gene	activation|nmod|START_ENTITY induced|dobj|activation tropomyosin_receptor_kinase_C|dep|induced required|nmod|tropomyosin_receptor_kinase_C required|dep|END_ENTITY	c-Src is required for tropomyosin_receptor_kinase_C -LRB- TrkC -RRB- - induced activation of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- - AKT pathway .
15091107	0	phosphatidylinositol_3-kinase	55,84	endothelial_nitric_oxide_synthase	17,50	phosphatidylinositol 3-kinase	endothelial nitric oxide synthase	5293	4846	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Up-regulation of endothelial_nitric_oxide_synthase via phosphatidylinositol_3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil hippocampus .
14688281	0	phosphatidylinositol_3-kinase	54,83	heme_oxygenase-1	14,30	phosphatidylinositol 3-kinase	heme oxygenase-1	18708(Tax:10090)	15368(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY expression|nmod|pathway expression|amod|END_ENTITY	Regulation of heme_oxygenase-1 expression through the phosphatidylinositol_3-kinase / Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol .
18972094	0	phosphatidylinositol_3-kinase	133,162	insulin	72,79	phosphatidylinositol 3-kinase	insulin	5293	3630	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Combined thiazolidinedione-metformin treatment synergistically improves insulin signalling to insulin_receptor_substrate-1-dependent phosphatidylinositol_3-kinase , atypical protein kinase C and protein kinase B/Akt in human diabetic muscle .
21062517	0	phosphatidylinositol_3-kinase	4,33	mammalian_target_of_rapamycin	34,63	phosphatidylinositol 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Can phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibition ERase them all ?
22452803	0	phosphatidylinositol_3-kinase	32,61	mammalian_target_of_rapamycin	62,91	phosphatidylinositol 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	NVP-BEZ235 and NVP-BGT226 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitors , enhance tumor and endothelial cell radiosensitivity .
23768063	0	phosphatidylinositol_3-kinase	17,46	mammalian_target_of_rapamycin	47,76	phosphatidylinositol 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|compound|END_ENTITY	NVP-BEZ235 , dual phosphatidylinositol_3-kinase / mammalian_target_of_rapamycin inhibitor , prominently enhances radiosensitivity of prostate_cancer cell line PC-3 .
17170431	0	phosphatidylinositol_3-kinase	44,73	p85	124,127	phosphatidylinositol 3-kinase	p85	5295	5296	Gene	Gene	pathway|amod|START_ENTITY activates|dobj|pathway activates|nmod|subunit subunit|amod|END_ENTITY	Influenza_A_virus NS1 protein activates the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt pathway by direct interaction with the p85 subunit of PI3K .
18420583	0	phosphatidylinositol_3-kinase	54,83	p85	115,118	phosphatidylinositol 3-kinase	p85	5295	5296	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Insulin-like_growth_factor-I stimulates Shc-dependent phosphatidylinositol_3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells .
20212113	0	phosphatidylinositol_3-kinase	57,86	p85	42,45	phosphatidylinositol 3-kinase	p85	5295	13601(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol_3-kinase .
22158866	0	phosphatidylinositol_3-kinase	115,144	p85	100,103	phosphatidylinositol 3-kinase	p85	5295	5296	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- .
16473619	0	phosphatidylinositol_3-kinase	69,98	p85_alpha	48,57	phosphatidylinositol 3-kinase	p85 alpha	5295	5295	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Assay and stimulation of the Rab5 GTPase by the p85_alpha subunit of phosphatidylinositol_3-kinase .
21077741	0	phosphatidylinositol_3-kinase	62,91	p85a	38,42	phosphatidylinositol 3-kinase	p85a	5291	5295	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Posttranscriptional regulation of the p85a adapter subunit of phosphatidylinositol_3-kinase in human leukemia cells .
9032108	0	phosphatidylinositol_3-kinase	89,118	p85alpha	58,66	phosphatidylinositol 3-kinase	p85alpha	5295	5295	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Identification of a common amino_acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol_3-kinase : effects on glucose_disappearance constant , glucose effectiveness , and the insulin sensitivity index .
25385636	0	phosphatidylinositol_3-kinase	53,82	p85b	45,49	phosphatidylinositol 3-kinase	p85b	5291	5296	Gene	Gene	activity|nmod|START_ENTITY activity|nmod|END_ENTITY	Oncogenic activity of the regulatory subunit p85b of phosphatidylinositol_3-kinase -LRB- PI3K -RRB- .
18828666	0	phosphatidylinositol_3-kinase	24,53	protein_kinase_B	63,79	phosphatidylinositol 3-kinase	protein kinase B	373752(Tax:8355)	399170(Tax:8355)	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|nsubj|involvement	Possible involvement of phosphatidylinositol_3-kinase , but not protein_kinase_B or glycogen_synthase_kinase_3beta , in progesterone-induced oocyte maturation in the Japanese brown frog , Rana japonica .
17008323	0	phosphatidylinositol_3-kinase	114,143	vascular_endothelial_growth_factor	24,58	phosphatidylinositol 3-kinase	vascular endothelial growth factor	5293	7422	Gene	Gene	Akt|amod|START_ENTITY induces|nmod|Akt induces|dobj|expression expression|compound|END_ENTITY	Ginsenoside-Rg1 induces vascular_endothelial_growth_factor expression through the glucocorticoid_receptor-related phosphatidylinositol_3-kinase / Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells .
19274678	0	phosphatidylinositol_3-kinase	108,137	vascular_endothelial_growth_factor	56,90	phosphatidylinositol 3-kinase	vascular endothelial growth factor	5293	7422	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Radix Astragali extract promotes angiogenesis involving vascular_endothelial_growth_factor receptor-related phosphatidylinositol_3-kinase / Akt-dependent pathway in human endothelial cells .
24890366	0	phosphatidylinositol_3-kinase	130,159	vascular_endothelial_growth_factor	69,103	phosphatidylinositol 3-kinase	vascular endothelial growth factor	5290	7422	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Gambogic_acid suppresses hypoxia-induced hypoxia-inducible_factor-1a / vascular_endothelial_growth_factor expression via inhibiting phosphatidylinositol_3-kinase / Akt/mammalian target protein of rapamycin pathway in multiple_myeloma cells .
20150971	0	phosphatidylinositol_3-kinase	108,137	zonula_occludens-1	84,102	phosphatidylinositol 3-kinase	zonula occludens-1	5293	7082	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Hypercholesterolaemic serum increases the permeability of endothelial cells through zonula_occludens-1 with phosphatidylinositol_3-kinase signaling pathway .
11042169	0	phosphatidylinositol_3-kinase_gamma	67,102	Janus_kinase_2	104,118	phosphatidylinositol 3-kinase gamma	Janus kinase 2	5294	3717	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol_3-kinase_gamma / Janus_kinase_2 / MEK-1-dependent pathway .
25068972	0	phosphatidylinositol_3_kinase	108,137	AKT	138,141	phosphatidylinositol 3 kinase	AKT	5294	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Effect of 2-arachidonoylglycerol on myosin_light_chain phosphorylation and platelet activation : The role of phosphatidylinositol_3_kinase / AKT pathway .
15635101	0	phosphatidylinositol_4-kinase_type-III_alpha	75,119	oxysterol_binding_protein	156,181	phosphatidylinositol 4-kinase type-III alpha	oxysterol binding protein	5297	5007	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	A plasma membrane pool of phosphatidylinositol_4-phosphate is generated by phosphatidylinositol_4-kinase_type-III_alpha : studies with the PH domains of the oxysterol_binding_protein and FAPP1 .
22539346	0	phosphatidylinositol_clathrin_assembly_lymphoid-myeloid_leukemia	8,72	APP	126,129	phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia	APP	233489(Tax:10090)	11820(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of phosphatidylinositol_clathrin_assembly_lymphoid-myeloid_leukemia -LRB- PICALM -RRB- in intracellular amyloid_precursor_protein -LRB- APP -RRB- processing and amyloid plaque pathogenesis .
18198489	0	phosphatidylinositol_glycan_Class_B	29,64	PIGB	66,70	phosphatidylinositol glycan Class B	PIGB	9488	9488	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	siRNA-mediated inhibition of phosphatidylinositol_glycan_Class_B -LRB- PIGB -RRB- confers resistance to methylmercury in HEK293 cells .
24241535	0	phosphatidylserine_synthase_1	34,63	PTDSS1	65,71	phosphatidylserine synthase 1	PTDSS1	9791	9791	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gain-of-function mutations in the phosphatidylserine_synthase_1 -LRB- PTDSS1 -RRB- gene cause Lenz-Majewski_syndrome .
12773045	0	phosphodiesterase-4	45,64	PDE4	66,70	phosphodiesterase-4	PDE4	5141	5141	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Optimization of a tertiary alcohol series of phosphodiesterase-4 -LRB- PDE4 -RRB- inhibitors : structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity .
18311187	0	phosphodiesterase-4	42,61	PDE4	63,67	phosphodiesterase-4	PDE4	5141	5141	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Short-term or long-term treatments with a phosphodiesterase-4 -LRB- PDE4 -RRB- inhibitor result in opposing agonist-induced Ca -LRB- 2 + -RRB- responses in endothelial cells .
23613014	0	phosphodiesterase-5	109,128	PDE-5	130,135	phosphodiesterase-5	PDE-5	8654	8654	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Decreased permeability surface area for glucose in obese women with postprandial_hyperglycemia : no effect of phosphodiesterase-5 -LRB- PDE-5 -RRB- inhibition .
25087294	0	phosphodiesterase-5	92,111	PDE-5	113,118	phosphodiesterase-5	PDE-5	8654	8654	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Exercise training improves erectile_dysfunction -LRB- ED -RRB- in patients with metabolic_syndrome on phosphodiesterase-5 -LRB- PDE-5 -RRB- inhibitors .
17690252	0	phosphodiesterase-5	14,33	PDE5	35,39	phosphodiesterase-5	PDE5	8654	8654	Gene	Gene	site|amod|START_ENTITY site|compound|END_ENTITY	Conversion of phosphodiesterase-5 -LRB- PDE5 -RRB- catalytic site to higher affinity by PDE5 inhibitors .
21602043	0	phosphodiesterase_10A	41,62	PDE10A	64,70	phosphodiesterase 10A	PDE10A	10846	10846	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Triazoloquinazolines as a novel class of phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
22365755	0	phosphodiesterase_10A	93,114	PDE10A	116,122	phosphodiesterase 10A	PDE10A	63885(Tax:10116)	63885(Tax:10116)	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of potent , selective , and metabolically stable 4 - -LRB- pyridin-3-yl -RRB- cinnolines as novel phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
24421319	0	phosphodiesterase_10A	49,70	PDE10A	72,78	phosphodiesterase 10A	PDE10A	10846	10846	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Pharmacology of JNJ-42314415 , a centrally active phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitor : a comparison of PDE10A inhibitors with D2 receptor blockers as potential antipsychotic drugs .
26077491	0	phosphodiesterase_10A	76,97	PDE10A	99,105	phosphodiesterase 10A	PDE10A	63885(Tax:10116)	63885(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Discovery of -LSB- -LRB- 11 -RRB- C -RSB- MK-8193 as a PET tracer to measure target engagement of phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
26113188	0	phosphodiesterase_10A	49,70	PDE10A	72,78	phosphodiesterase 10A	PDE10A	10846	10846	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
26113188	0	phosphodiesterase_10A	49,70	PDE10A	72,78	phosphodiesterase 10A	PDE10A	10846	10846	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	BN/CC isosterism in borazaronaphthalenes towards phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
26597534	0	phosphodiesterase_10A	122,143	PDE10A	145,151	phosphodiesterase 10A	PDE10A	10846	10846	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Fragment-assisted hit investigation involving integrated HTS and fragment screening : Application to the identification of phosphodiesterase_10A -LRB- PDE10A -RRB- inhibitors .
21960012	0	phosphodiesterase_1B	23,43	PDE1B	45,50	phosphodiesterase 1B	PDE1B	281970(Tax:9913)	281970(Tax:9913)	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Genetic association of phosphodiesterase_1B -LRB- PDE1B -RRB- with carcass traits in Korean cattle .
19741056	0	phosphodiesterase_1C	18,38	renin	48,53	phosphodiesterase 1C	renin	5137	5972	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|release release|compound|END_ENTITY	Calcium-dependent phosphodiesterase_1C inhibits renin release from isolated juxtaglomerular cells .
23986500	0	phosphodiesterase_4	18,37	ERK	0,3	phosphodiesterase 4	ERK	5141	5594	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	ERK regulation of phosphodiesterase_4 enhances dopamine-stimulated AMPA receptor membrane insertion .
8651945	0	phosphodiesterase_4	49,68	PDE4	70,74	phosphodiesterase 4	PDE4	5141	5141	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Association of the anti-inflammatory activity of phosphodiesterase_4 -LRB- PDE4 -RRB- inhibitors with either inhibition of PDE4 catalytic activity or competition for -LSB- 3H -RSB- rolipram binding .
26011935	0	phosphodiesterase_4B	12,32	IL-8	36,40	phosphodiesterase 4B	IL-8	5142	3576	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	phosphodiesterase_4B	12,32	IL-8	36,40	phosphodiesterase 4B	IL-8	5142	3576	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	phosphodiesterase_4B	99,119	IL-8	36,40	phosphodiesterase 4B	IL-8	5142	3576	Gene	Gene	inhibitor|amod|START_ENTITY evaluated|nmod|inhibitor role|parataxis|evaluated role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	phosphodiesterase_4B	99,119	IL-8	36,40	phosphodiesterase 4B	IL-8	5142	3576	Gene	Gene	inhibitor|amod|START_ENTITY evaluated|nmod|inhibitor role|parataxis|evaluated role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
18329668	0	phosphodiesterase_4B	35,55	PDE4B	28,33	phosphodiesterase 4B	PDE4B	5142	5142	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Positive association of the PDE4B -LRB- phosphodiesterase_4B -RRB- gene with schizophrenia in the Japanese population .
18785206	0	phosphodiesterase_4B	48,68	PDE4B	70,75	phosphodiesterase 4B	PDE4B	5142	5142	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gene expression and association analyses of the phosphodiesterase_4B -LRB- PDE4B -RRB- gene in major_depressive_disorder in the Japanese population .
26011935	0	phosphodiesterase_4B	12,32	phosphodiesterase_4B	99,119	phosphodiesterase 4B	phosphodiesterase 4B	5142	5142	Gene	Gene	role|nmod|START_ENTITY role|parataxis|evaluated evaluated|nmod|inhibitor inhibitor|amod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	phosphodiesterase_4B	12,32	phosphodiesterase_4B	99,119	phosphodiesterase 4B	phosphodiesterase 4B	5142	5142	Gene	Gene	role|nmod|START_ENTITY role|parataxis|evaluated evaluated|nmod|inhibitor inhibitor|amod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	phosphodiesterase_4B	99,119	phosphodiesterase_4B	12,32	phosphodiesterase 4B	phosphodiesterase 4B	5142	5142	Gene	Gene	inhibitor|amod|START_ENTITY evaluated|nmod|inhibitor role|parataxis|evaluated role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
26011935	0	phosphodiesterase_4B	99,119	phosphodiesterase_4B	12,32	phosphodiesterase 4B	phosphodiesterase 4B	5142	5142	Gene	Gene	inhibitor|amod|START_ENTITY evaluated|nmod|inhibitor role|parataxis|evaluated role|nmod|END_ENTITY	The role of phosphodiesterase_4B in IL-8 / LTB4-induced human neutrophil chemotaxis evaluated with a phosphodiesterase_4B inhibitor .
16543535	0	phosphodiesterase_4D	53,73	PDE4D	80,85	phosphodiesterase 4D	PDE4D	5144	5144	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of single nucleotide polymorphisms in the phosphodiesterase_4D gene -LRB- PDE4D -RRB- and their association with ischaemic_stroke in a large German cohort .
20540798	0	phosphodiesterase_4D	35,55	PDE4D	57,62	phosphodiesterase 4D	PDE4D	5144	5144	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Sex-differential genetic effect of phosphodiesterase_4D -LRB- PDE4D -RRB- on carotid_atherosclerosis .
23120769	0	phosphodiesterase_4D	39,59	PDE4D	61,66	phosphodiesterase 4D	PDE4D	5144	5144	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	-LSB- Association of cerebral_stroke with a phosphodiesterase_4D -LRB- PDE4D -RRB- gene polymorphism in the Moscow population -RSB- .
25126889	0	phosphodiesterase_4D	171,191	PDE4D	193,198	phosphodiesterase 4D	PDE4D	5144	5144	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis , biological evaluation , and molecular modeling of new 3 - -LRB- cyclopentyloxy -RRB- -4 - methoxybenzaldehyde_O - -LRB- 2 - -LRB- 2,6-dimethylmorpholino -RRB- -2 - oxoethyl -RRB- _ Oxime -LRB- GEBR-7b -RRB- related phosphodiesterase_4D -LRB- PDE4D -RRB- inhibitors .
16913726	0	phosphodiesterase_5	62,81	PDE5	83,87	phosphodiesterase 5	PDE5	8654	8654	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitory activity as potential agents for treatment of erectile_dysfunction .
20400309	0	phosphodiesterase_5	74,93	PDE5	95,99	phosphodiesterase 5	PDE5	8654	8654	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	1 - -LRB- 2 - -LRB- 2,2,2-trifluoroethoxy -RRB- ethyl-1H-pyrazolo -LSB- 4,3-d -RSB- pyrimidines as potent phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitors .
20443228	0	phosphodiesterase_5	58,77	PDE5	79,83	phosphodiesterase 5	PDE5	8654	8654	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	1 - -LRB- 2-Ethoxyethyl -RRB- -1 H-pyrazolo -LSB- 4,3-d -RSB- pyrimidines as potent phosphodiesterase_5 -LRB- PDE5 -RRB- inhibitors .
24497218	0	phosphodiesterase_8B	37,57	PDE8B	59,64	phosphodiesterase 8B	PDE8B	8622	8622	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Frequency and effect on serum TSH of phosphodiesterase_8B -LRB- PDE8B -RRB- gene polymorphisms in patients with sporadic nonautoimmune subclinical_hypothyroidism .
10417351	0	phosphodiesterase_type_3B	34,59	PDE3B	61,66	phosphodiesterase type 3B	PDE3B	29516(Tax:10116)	29516(Tax:10116)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation and activation of phosphodiesterase_type_3B -LRB- PDE3B -RRB- in adipocytes in response to serine/threonine phosphatase inhibitors : deactivation of PDE3B in vitro by protein phosphatase type 2A .
18854969	0	phosphodiesterase_type_5	15,39	PDE5	41,45	phosphodiesterase type 5	PDE5	8654	8654	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	-LSB- The basics of phosphodiesterase_type_5 -LRB- PDE5 -RRB- inhibition in urology -RSB- .
21714539	0	phosphodiesterase_type_5	92,116	PDE5	118,122	phosphodiesterase type 5	PDE5	8654	8654	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Utilization of halogen bond in lead optimization : a case study of rational design of potent phosphodiesterase_type_5 -LRB- PDE5 -RRB- inhibitors .
11137871	0	phosphodiesterase_type_5	52,76	T-1032	27,33	phosphodiesterase type 5	T-1032	171115(Tax:10116)	1070362(Tax:209261)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	Pharmacological profile of T-1032 , a novel specific phosphodiesterase_type_5 inhibitor , in isolated rat aorta and rabbit corpus cavernosum .
11430921	0	phosphodiesterase_type_5	25,49	T-1032	0,6	phosphodiesterase type 5	T-1032	171115(Tax:10116)	1070362(Tax:209261)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	T-1032 , a novel specific phosphodiesterase_type_5 inhibitor , increases venous compliance in anesthetized rats .
12419952	0	phosphodiesterase_type_5	55,79	T-1032	29,35	phosphodiesterase type 5	T-1032	171115(Tax:10116)	1070362(Tax:209261)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	Acute and chronic effects of T-1032 , a novel selective phosphodiesterase_type_5 inhibitor , on monocrotaline-induced pulmonary_hypertension in rats .
18554583	0	phosphodiesterase_type_5	69,93	T0156	50,55	phosphodiesterase type 5	T0156	171115(Tax:10116)	1067740(Tax:209261)	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	Prevention of nitroglycerin tolerance in vitro by T0156 , a selective phosphodiesterase_type_5 inhibitor .
18966765	0	phosphoenolpyruvate-carboxylase	25,56	PEPC	58,62	phosphoenolpyruvate-carboxylase	PEPC	5105	5105	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of the enzyme phosphoenolpyruvate-carboxylase -LRB- PEPC -RRB- by different pollutants .
16267049	0	phosphoenolpyruvate_carboxykinase	50,83	Estrogen-related_receptor_alpha	0,31	phosphoenolpyruvate carboxykinase	Estrogen-related receptor alpha	5106	2101	Gene	Gene	transcription|amod|START_ENTITY repressor|nmod|transcription repressor|nsubj|END_ENTITY	Estrogen-related_receptor_alpha is a repressor of phosphoenolpyruvate_carboxykinase gene transcription .
17095578	0	phosphoenolpyruvate_carboxykinase	18,51	Insulin	0,7	phosphoenolpyruvate carboxykinase	Insulin	5106	3630	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	Insulin represses phosphoenolpyruvate_carboxykinase gene transcription by causing the rapid disruption of an active transcription complex : a potential epigenetic effect .
1377912	0	phosphoenolpyruvate_carboxykinase	14,47	PEPCK	49,54	phosphoenolpyruvate carboxykinase	PEPCK	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- chimeras in renal epithelial cells .
14652357	0	phosphoenolpyruvate_carboxykinase	39,72	PEPCK	74,79	phosphoenolpyruvate carboxykinase	PEPCK	18534(Tax:10090)	18534(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	RNA_polymerase_II association with the phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- promoter is reduced in vitamin_A-deficient mice .
7982956	0	phosphoenolpyruvate_carboxykinase	77,110	PEPCK	112,117	phosphoenolpyruvate carboxykinase	PEPCK	5106	5106	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Potential convergence of insulin and cAMP signal transduction systems at the phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene promoter through CCAAT/enhancer binding protein -LRB- C/EBP -RRB- .
8114762	0	phosphoenolpyruvate_carboxykinase	147,180	PEPCK	182,187	phosphoenolpyruvate carboxykinase	PEPCK	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Involvement of 3 ' ,5 ' - cyclic_adenosine_monophosphate regulatory element binding protein -LRB- CREB -RRB- in both basal and hormone-mediated expression of the phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- gene .
8475501	0	phosphoenolpyruvate_carboxykinase	21,54	PEPCK	56,61	phosphoenolpyruvate carboxykinase	PEPCK	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Reduction of hepatic phosphoenolpyruvate_carboxykinase -LRB- PEPCK -RRB- activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin -LRB- TCDD -RRB- is due to decreased mRNA levels .
3569139	0	phosphoenolpyruvate_carboxykinase	52,85	PEPck	87,92	phosphoenolpyruvate carboxykinase	PEPck	362282(Tax:10116)	362282(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Nuclear 3,5,3 ' - triiodothyronine receptor occupancy , phosphoenolpyruvate_carboxykinase -LRB- PEPck -RRB- messenger ribonucleic acid levels and PEPck enzyme activity in rat liver .
2843505	1	phosphoenolpyruvate_carboxykinase	74,107	gene_33	132,139	phosphoenolpyruvate carboxykinase	gene 33	5106	54206	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Inhibition of the phosphoenolpyruvate_carboxykinase gene and stimulation of gene_33 in a single cell type .
11518712	0	phosphoenolpyruvate_carboxykinase	75,108	glucocorticoid_receptor	44,67	phosphoenolpyruvate carboxykinase	glucocorticoid receptor	5106	2908	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Accessory factors facilitate the binding of glucocorticoid_receptor to the phosphoenolpyruvate_carboxykinase gene promoter .
3331712	0	phosphoenolpyruvate_carboxykinase	18,51	insulin	96,103	phosphoenolpyruvate carboxykinase	insulin	5106	3630	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The inhibition of phosphoenolpyruvate_carboxykinase -LRB- guanosine_triphosphate -RRB- gene expression by insulin is not mediated by protein kinase C .
6353247	0	phosphoenolpyruvate_carboxykinase	35,68	insulin	77,84	phosphoenolpyruvate carboxykinase	insulin	5106	3630	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Inhibition of transcription of the phosphoenolpyruvate_carboxykinase gene by insulin .
10655271	0	phosphoenolpyruvate_carboxykinase	100,133	interleukin_6	83,96	phosphoenolpyruvate carboxykinase	interleukin 6	362282(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Phosphatidylinositol 3-kinase and protein kinase C contribute to the inhibition by interleukin_6 of phosphoenolpyruvate_carboxykinase gene expression in cultured rat hepatocytes .
16936335	0	phosphoenolpyruvate_carboxylase	39,70	PEPC	72,76	phosphoenolpyruvate carboxylase	PEPC	5105	5105	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Light regulation of the photosynthetic phosphoenolpyruvate_carboxylase -LRB- PEPC -RRB- in Hydrilla verticillata .
9252390	0	phosphofructokinase-M	15,36	caveolin-3	42,52	phosphofructokinase-M	caveolin-3	18642(Tax:10090)	12391(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of phosphofructokinase-M with caveolin-3 in differentiated_skeletal_myotubes .
16876970	0	phosphoglucomutase	47,65	PGM	67,70	phosphoglucomutase	PGM	105348078	105348078	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular identification and expression of the phosphoglucomutase -LRB- PGM -RRB- gene from the Pacific_oyster Crassostrea_gigas .
2576634	0	phosphoglucomutase-1	73,93	pgm-1	58,63	phosphoglucomutase-1	pgm-1	66681(Tax:10090)	66681(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Linkage of the Dao-1 gene for D-amino-acid_oxidase to the pgm-1 gene for phosphoglucomutase-1 on the mouse chromosome 5 .
2935481	0	phosphoglucomutase_1	41,61	PGM1	70,74	phosphoglucomutase 1	PGM1	5236	5236	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	A new partially deficient variant in the phosphoglucomutase_1 system , PGM1 * W31 .
12174217	0	phosphoglucomutase_3	24,44	N-acetylglucosamine-phosphate_mutase	55,91	phosphoglucomutase 3	N-acetylglucosamine-phosphate mutase	5238	5238	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human phosphoglucomutase_3 -LRB- PGM3 -RRB- as N-acetylglucosamine-phosphate_mutase -LRB- AGM1 -RRB- .
24589341	0	phosphoglucomutase_3	20,40	PGM3	42,46	phosphoglucomutase 3	PGM3	5238	5238	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Autosomal recessive phosphoglucomutase_3 -LRB- PGM3 -RRB- mutations link glycosylation defects to atopy , immune_deficiency , autoimmunity , and neurocognitive_impairment .
26482871	0	phosphoglucomutase_3	120,140	PGM3	142,146	phosphoglucomutase 3	PGM3	5238	5238	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Susceptibility to infections , without concomitant hyper-IgE , reported in 1976 , is caused by hypomorphic mutation in the phosphoglucomutase_3 -LRB- PGM3 -RRB- gene .
6462057	0	phosphoglucomutase_locus_1	13,39	PGM1	41,45	phosphoglucomutase locus 1	PGM1	5236	5236	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Subtyping of phosphoglucomutase_locus_1 -LRB- PGM1 -RRB- polymorphism in some populations of Rwanda : description of variant phenotypes , `` haplotype '' frequencies , and linkage disequilibrium data .
15613449	0	phosphoglucose_isomerase	45,69	autocrine_motility_factor	19,44	phosphoglucose isomerase	autocrine motility factor	2821	2821	Gene	Gene	roles|dep|START_ENTITY roles|nmod|END_ENTITY	Novel roles of the autocrine_motility_factor / phosphoglucose_isomerase in tumor_malignancy .
16126909	0	phosphoglucose_isomerase	14,38	autocrine_motility_factor	39,64	phosphoglucose isomerase	autocrine motility factor	2821	2821	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|compound|END_ENTITY	Regulation of phosphoglucose_isomerase / autocrine_motility_factor expression by hypoxia .
18301993	0	phosphoglucose_isomerase	155,179	autocrine_motility_factor	129,154	phosphoglucose isomerase	autocrine motility factor	2821	2821	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy : a possible association with autocrine_motility_factor / phosphoglucose_isomerase expression .
10770936	0	phosphoglucose_isomerase	25,49	neuroleukin	76,87	phosphoglucose isomerase	neuroleukin	14751(Tax:10090)	14751(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	The crystal structure of phosphoglucose_isomerase / autocrine_motility_factor / neuroleukin complexed with its carbohydrate_phosphate inhibitors suggests its substrate/receptor recognition .
25404730	0	phosphoglycerate_dehydrogenase	35,65	p53	0,3	phosphoglycerate dehydrogenase	p53	26227	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	p53 Protein-mediated regulation of phosphoglycerate_dehydrogenase -LRB- PHGDH -RRB- is crucial for the apoptotic response upon serine starvation .
2194802	0	phosphoglycerate_kinase	48,71	ATP4	13,17	phosphoglycerate kinase	ATP4	850370(Tax:4932)	856027(Tax:4932)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	The roles of ATP4 - and Mg2 + in control steps of phosphoglycerate_kinase .
1465095	0	phosphoglycerate_kinase	32,55	Pgk	57,60	phosphoglycerate kinase	Pgk	33461(Tax:7227)	33461(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and expression of the phosphoglycerate_kinase -LRB- Pgk -RRB- gene of Drosophila_melanogaster .
12174867	0	phosphoglycerate_kinase_1	24,49	PGK1	51,55	phosphoglycerate kinase 1	PGK1	5230	5230	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of human phosphoglycerate_kinase_1 -LRB- PGK1 -RRB- induces a multidrug resistance phenotype .
1765379	0	phosphoglycerate_kinase_1	69,94	PGK1	96,100	phosphoglycerate kinase 1	PGK1	5230	5230	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nucleotide sequence of the 3 ' nuclease-sensitive region of the human phosphoglycerate_kinase_1 -LRB- PGK1 -RRB- gene .
3559479	0	phosphohexose_isomerase	67,90	CSF	98,101	phosphohexose isomerase	CSF	2821	1437	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	Clinical significance and source of raised catalytic activities of phosphohexose_isomerase in the CSF in meningitis .
23119750	0	phosphohexose_isomerase	15,38	PHI	40,43	phosphohexose isomerase	PHI	2821	2821	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Study of serum phosphohexose_isomerase -LRB- PHI -RRB- levels in the management of head and neck_malignancies .
5988895	0	phosphohexose_isomerase	22,45	aminopeptidase	58,72	phosphohexose isomerase	aminopeptidase	2821	10404	Gene	Gene	START_ENTITY|dobj|levels levels|amod|END_ENTITY	-LSB- Changes in the serum phosphohexose_isomerase and leucine aminopeptidase levels during lysozyme treatment of viral hepatitis in childhood -RSB- .
10873589	0	phosphohexose_isomerase	40,63	autocrine_motility_factor	14,39	phosphohexose isomerase	autocrine motility factor	2821	2821	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of autocrine_motility_factor / phosphohexose_isomerase in Cos7 cells .
3191476	0	phosphohexose_isomerase	37,60	neuroleukin	133,144	phosphohexose isomerase	neuroleukin	2821	2821	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and characterization of phosphohexose_isomerase from human gastrointestinal_carcinoma and its potential relationship to neuroleukin .
17357072	0	phosphohippolin	112,127	FXYD6	91,96	phosphohippolin	FXYD6	53826	53826	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene , encoding phosphohippolin , in susceptibility to schizophrenia .
10962556	0	phosphoinositide-3-OH_kinase	28,56	PI3-K	58,63	phosphoinositide-3-OH kinase	PI3-K	5295	5295	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Inhibition of EGFR-mediated phosphoinositide-3-OH_kinase -LRB- PI3-K -RRB- signaling and glioblastoma phenotype by signal-regulatory proteins -LRB- SIRPs -RRB- .
25281324	0	phosphoinositide-3-kinase	114,139	AKT	140,143	phosphoinositide-3-kinase	AKT	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Biphasic modulation of paracellular claudin-5 expression in mouse brain endothelial cells is mediated through the phosphoinositide-3-kinase / AKT pathway .
17302912	0	phosphoinositide-3-kinase	50,75	Akt	76,79	phosphoinositide-3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	neuroprotective|amod|START_ENTITY neuroprotective|compound|END_ENTITY	Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase / Akt neuroprotective signaling pathway .
18644865	0	phosphoinositide-3_kinase	51,76	Akt	77,80	phosphoinositide-3 kinase	Akt	5290	207	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	The forkhead transcription factor FOXO3a increases phosphoinositide-3_kinase / Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression .
18538520	0	phosphoinositide-3_kinase	100,125	p85alpha	80,88	phosphoinositide-3 kinase	p85alpha	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Hyperactivity , memory_deficit and anxiety-related_behaviors in mice lacking the p85alpha subunit of phosphoinositide-3_kinase .
17531483	0	phosphoinositide-dependent_kinase-1	17,52	PDK1	54,58	phosphoinositide-dependent kinase-1	PDK1	5163	5163	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Indolinone based phosphoinositide-dependent_kinase-1 -LRB- PDK1 -RRB- inhibitors .
17544272	0	phosphoinositide-dependent_kinase-1	17,52	PDK1	54,58	phosphoinositide-dependent kinase-1	PDK1	5163	5163	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Indolinone based phosphoinositide-dependent_kinase-1 -LRB- PDK1 -RRB- inhibitors .
20044479	0	phosphoinositide-dependent_kinase-1	75,110	insulin-like_growth_factor-1	24,52	phosphoinositide-dependent kinase-1	insulin-like growth factor-1	5163	3479	Gene	Gene	signaling|nmod|START_ENTITY signaling|amod|END_ENTITY	Selective disruption of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- signaling via phosphoinositide-dependent_kinase-1 prevents the protective effect of IGF-1 on human cancer cell death .
19910471	0	phosphoinositide-dependent_kinase_1	16,51	c-Jun	0,5	phosphoinositide-dependent kinase 1	c-Jun	228026(Tax:10090)	16476(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	c-Jun regulates phosphoinositide-dependent_kinase_1 transcription : implication for Akt and protein kinase C activities and melanoma_tumorigenesis .
2558935	0	phosphoinositide-specific_phospholipase_C	28,69	Insulin	0,7	phosphoinositide-specific phospholipase C	Insulin	23236	3630	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Insulin does not activate a phosphoinositide-specific_phospholipase_C in adipocytes .
11306679	0	phosphoinositide_3-Kinase	84,109	c-Jun_N-terminal_kinase	34,57	phosphoinositide 3-Kinase	c-Jun N-terminal kinase	5294	5599	Gene	Gene	signaling|advcl|START_ENTITY END_ENTITY|acl|signaling	Zn -LRB- 2 + -RRB- induces stimulation of the c-Jun_N-terminal_kinase signaling pathway through phosphoinositide_3-Kinase .
12242282	0	phosphoinositide_3-kinase	20,45	AKT	46,49	phosphoinositide 3-kinase	AKT	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	v-Crk activates the phosphoinositide_3-kinase / AKT pathway by utilizing focal_adhesion_kinase and H-Ras .
16935846	0	phosphoinositide_3-kinase	103,128	AKT	129,132	phosphoinositide 3-kinase	AKT	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Regulation of the RAP1/RAF -1 / extracellularly regulated kinase-1 / 2 cascade and prolactin release by the phosphoinositide_3-kinase / AKT pathway in pituitary cells .
17018259	0	phosphoinositide_3-kinase	30,55	AKT	56,59	phosphoinositide 3-kinase	AKT	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Emodin negatively affects the phosphoinositide_3-kinase / AKT signalling pathway : a study on its mechanism of action .
20501798	0	phosphoinositide_3-kinase	10,35	AKT	36,39	phosphoinositide 3-kinase	AKT	5293	207	Gene	Gene	START_ENTITY|parataxis|confers confers|nsubj|signaling signaling|compound|END_ENTITY	Activated phosphoinositide_3-kinase / AKT signaling confers resistance to trastuzumab but not lapatinib .
10330402	0	phosphoinositide_3-kinase	26,51	Akt	70,73	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	protein_kinase_B|amod|START_ENTITY protein_kinase_B|appos|END_ENTITY	Changes in the balance of phosphoinositide_3-kinase / protein_kinase_B -LRB- Akt -RRB- and the mitogen-activated protein kinases -LRB- ERK/p38MAPK -RRB- determine a phenotype of visceral and vascular smooth muscle cells .
11062076	0	phosphoinositide_3-kinase	28,53	Akt	54,57	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Peroxynitrite activates the phosphoinositide_3-kinase / Akt pathway in human skin primary fibroblasts .
11815624	0	phosphoinositide_3-kinase	44,69	Akt	70,73	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Lack of evidence for the involvement of the phosphoinositide_3-kinase / Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension .
12738789	0	phosphoinositide_3-kinase	56,81	Akt	82,85	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Bcl-xL mediates a survival mechanism independent of the phosphoinositide_3-kinase / Akt pathway in prostate_cancer cells .
12773158	0	phosphoinositide_3-kinase	73,98	Akt	99,102	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	United at last : the tuberous_sclerosis complex gene products connect the phosphoinositide_3-kinase / Akt pathway to mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling .
12931221	0	phosphoinositide_3-kinase	4,29	Akt	30,33	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	The phosphoinositide_3-kinase / Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27 -LRB- Kip1 -RRB- and control of cyclin_D1 expression .
16288212	0	phosphoinositide_3-kinase	4,29	Akt	30,33	phosphoinositide 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|essential essential|nsubj|END_ENTITY	The phosphoinositide_3-kinase / Akt pathway is essential for the retinoic_acid-induced differentiation of F9 cells .
16707436	0	phosphoinositide_3-kinase	4,29	Akt	30,33	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	The phosphoinositide_3-kinase / Akt pathway : a new target in human renal_cell_carcinoma therapy .
16751276	0	phosphoinositide_3-kinase	50,75	Akt	76,79	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	signal|amod|START_ENTITY signal|compound|END_ENTITY	Ultrasensitive and absolute quantification of the phosphoinositide_3-kinase / Akt signal transduction pathway by mass spectrometry .
16820027	0	phosphoinositide_3-kinase	38,63	Akt	64,67	phosphoinositide 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	cascade|amod|START_ENTITY cascade|compound|END_ENTITY	Signalling mechanisms mediated by the phosphoinositide_3-kinase / Akt cascade in synaptic plasticity and memory in the rat .
17537408	0	phosphoinositide_3-kinase	121,146	Akt	147,150	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Osteopontin is a myosphere-derived secretory molecule that promotes angiogenic progenitor cell proliferation through the phosphoinositide_3-kinase / Akt pathway .
17581609	0	phosphoinositide_3-kinase	124,149	Akt	150,153	phosphoinositide 3-kinase	Akt	5291	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute_myeloid_leukemia cells via the phosphoinositide_3-kinase / Akt pathway .
18440486	0	phosphoinositide_3-kinase	54,79	Akt	80,83	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Clinicopathological significance of PTEN_loss and the phosphoinositide_3-kinase / Akt pathway in sporadic colorectal_neoplasms : is PTEN_loss predictor of local recurrence ?
18604870	0	phosphoinositide_3-kinase	101,126	Akt	127,130	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Epstein-Barr_virus upregulates phosphorylated heat_shock protein 27 kDa in carcinoma cells using the phosphoinositide_3-kinase / Akt pathway .
18953257	0	phosphoinositide_3-kinase	57,82	Akt	83,86	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Apigenin inhibits the GLUT-1 glucose transporter and the phosphoinositide_3-kinase / Akt pathway in human pancreatic_cancer cells .
19706758	0	phosphoinositide_3-kinase	27,52	Akt	146,149	phosphoinositide 3-kinase	Akt	5290	207	Gene	Gene	alterations|nmod|START_ENTITY alterations|parataxis|confer confer|nmod|therapeutic therapeutic|nmod|END_ENTITY	Genetic alterations in the phosphoinositide_3-kinase / Akt signaling pathway confer sensitivity of thyroid_cancer cells to therapeutic targeting of Akt and mammalian_target_of_rapamycin .
19706758	0	phosphoinositide_3-kinase	27,52	Akt	53,56	phosphoinositide 3-kinase	Akt	5290	207	Gene	Gene	alterations|nmod|START_ENTITY alterations|parataxis|confer confer|nsubj|signaling signaling|compound|END_ENTITY	Genetic alterations in the phosphoinositide_3-kinase / Akt signaling pathway confer sensitivity of thyroid_cancer cells to therapeutic targeting of Akt and mammalian_target_of_rapamycin .
20506627	0	phosphoinositide_3-kinase	27,52	Akt	53,56	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Cobalt_chloride stimulates phosphoinositide_3-kinase / Akt signaling through the epidermal_growth_factor_receptor in oral_squamous_cell_carcinoma .
21300751	0	phosphoinositide_3-kinase	91,116	Akt	117,120	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide_3-kinase / Akt signalling .
21695271	0	phosphoinositide_3-kinase	92,117	Akt	118,121	phosphoinositide 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Anti-malarial drug artesunate attenuates experimental allergic_asthma via inhibition of the phosphoinositide_3-kinase / Akt pathway .
22234835	0	phosphoinositide_3-kinase	65,90	Akt	91,94	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide_3-kinase / Akt pathway in hepatocellular_carcinoma .
23010818	0	phosphoinositide_3-kinase	82,107	Akt	108,111	phosphoinositide 3-kinase	Akt	18708(Tax:10090)	11651(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|dep|kinase kinase|amod|END_ENTITY	Polysaccharide from Ganoderma atrum induces tumor necrosis factor-a secretion via phosphoinositide_3-kinase / Akt , mitogen-activated protein kinase and nuclear factor-kB signaling pathways in RAW264 .7 cells .
24212403	0	phosphoinositide_3-kinase	145,170	Akt	171,174	phosphoinositide 3-kinase	Akt	298947(Tax:10116)	24185(Tax:10116)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	C1q tumor necrosis factor-related protein-3 protects mesenchymal stem cells against hypoxia - and serum deprivation-induced apoptosis through the phosphoinositide_3-kinase / Akt pathway .
24685819	0	phosphoinositide_3-kinase	106,131	Akt	132,135	phosphoinositide 3-kinase	Akt	5293	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Endothelium-independent hypoxic contraction of porcine coronary arteries may be mediated by activation of phosphoinositide_3-kinase / Akt pathway .
18697750	0	phosphoinositide_3-kinase	33,58	Gab2	0,4	phosphoinositide 3-kinase	Gab2	5293	9846	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Gab2 is involved in differential phosphoinositide_3-kinase signaling by two splice forms of c-Kit .
24223153	0	phosphoinositide_3-kinase	57,82	HSPB6	45,50	phosphoinositide 3-kinase	HSPB6	5295	126393	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Direct association of heat_shock protein 20 -LRB- HSPB6 -RRB- with phosphoinositide_3-kinase -LRB- PI3K -RRB- in human hepatocellular_carcinoma : regulation of the PI3K activity .
21714526	0	phosphoinositide_3-kinase	36,61	PI3K	63,67	phosphoinositide 3-kinase	PI3K	5293	5293	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure-activity relationships of phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors : investigations of various 6,5-heterocycles to improve metabolic stability .
21953448	0	phosphoinositide_3-kinase	188,213	PI3K	215,219	phosphoinositide 3-kinase	PI3K	5293	5293	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Hydrogen_sulfide and L-cysteine increase phosphatidylinositol_3 ,4,5 - trisphosphate -LRB- PIP3 -RRB- and glucose utilization by inhibiting phosphatase and tensin homolog -LRB- PTEN -RRB- protein and activating phosphoinositide_3-kinase -LRB- PI3K -RRB- / serine/threonine protein kinase -LRB- AKT -RRB- / protein kinase C / -LRB- PKC / -RRB- in 3T3l1 adipocytes .
22905224	0	phosphoinositide_3-kinase	69,94	PI3K	96,100	phosphoinositide 3-kinase	PI3K	5293	5293	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide_3-kinase -LRB- PI3K -RRB- inhibitors .
26236186	0	phosphoinositide_3-kinase	56,81	PI3K	83,87	phosphoinositide 3-kinase	PI3K	18708(Tax:10090)	18708(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Shiga toxin type-2 -LRB- Stx2 -RRB- induces glutamate release via phosphoinositide_3-kinase -LRB- PI3K -RRB- pathway in murine neurons .
16094730	0	phosphoinositide_3-kinase	27,52	Protein_kinase	0,14	phosphoinositide 3-kinase	Protein kinase	5293	1022	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Protein_kinase activity of phosphoinositide_3-kinase regulates beta-adrenergic receptor endocytosis .
12773158	0	phosphoinositide_3-kinase	73,98	mammalian_target_of_rapamycin	114,143	phosphoinositide 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	pathway|amod|START_ENTITY connect|dobj|pathway connect|nmod|END_ENTITY	United at last : the tuberous_sclerosis complex gene products connect the phosphoinositide_3-kinase / Akt pathway to mammalian_target_of_rapamycin -LRB- mTOR -RRB- signalling .
17971449	0	phosphoinositide_3-kinase	47,72	mammalian_target_of_rapamycin	12,41	phosphoinositide 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Coupling of mammalian_target_of_rapamycin with phosphoinositide_3-kinase signaling pathway regulates protein phosphatase 2A - and glycogen synthase kinase-3 - dependent phosphorylation of Tau .
19372588	0	phosphoinositide_3-kinase	29,54	mammalian_target_of_rapamycin	55,84	phosphoinositide 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|compound|END_ENTITY	Targeting melanoma with dual phosphoinositide_3-kinase / mammalian_target_of_rapamycin inhibitors .
19789349	0	phosphoinositide_3-kinase	5,30	mammalian_target_of_rapamycin	31,60	phosphoinositide 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	START_ENTITY|parataxis|strategy strategy|nsubj|blockade blockade|compound|END_ENTITY	Dual phosphoinositide_3-kinase / mammalian_target_of_rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small_cell_lung_cancer harboring K-RAS mutations .
21714526	0	phosphoinositide_3-kinase	36,61	mammalian_target_of_rapamycin	69,98	phosphoinositide 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Structure-activity relationships of phosphoinositide_3-kinase -LRB- PI3K -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- dual inhibitors : investigations of various 6,5-heterocycles to improve metabolic stability .
21854819	0	phosphoinositide_3-kinase	92,117	mammalian_target_of_rapamycin	118,147	phosphoinositide 3-kinase	mammalian target of rapamycin	5293	2475	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Insulin-induced neurite-like process outgrowth : acceleration of tau protein synthesis via a phosphoinositide_3-kinase ~ mammalian_target_of_rapamycin pathway .
23533654	0	phosphoinositide_3-kinase	5,30	mammalian_target_of_rapamycin	31,60	phosphoinositide 3-kinase	mammalian target of rapamycin	5290	2475	Gene	Gene	START_ENTITY|parataxis|has has|nsubj|NVP-BEZ235 NVP-BEZ235|amod|END_ENTITY	Dual phosphoinositide_3-kinase / mammalian_target_of_rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal_carcinoma .
16707418	0	phosphoinositide_3-kinase	98,123	matrix_metalloproteinase-2	56,82	phosphoinositide 3-kinase	matrix metalloproteinase-2	5293	4313	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Bcl-w promotes gastric_cancer cell invasion by inducing matrix_metalloproteinase-2 expression via phosphoinositide_3-kinase , Akt , and Sp1 .
19106103	0	phosphoinositide_3-kinase	66,91	myocyte_enhancer_factor_2	120,145	phosphoinositide 3-kinase	myocyte enhancer factor 2	5293	4205	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide_3-kinase / AKT-dependent activation of myocyte_enhancer_factor_2 .
19679877	0	phosphoinositide_3-kinase	8,33	p110alpha	35,44	phosphoinositide 3-kinase	p110alpha	18708(Tax:10090)	18706(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Reduced phosphoinositide_3-kinase -LRB- p110alpha -RRB- activation increases the susceptibility to atrial_fibrillation .
18544649	0	phosphoinositide_3-kinase	24,49	p110beta	4,12	phosphoinositide 3-kinase	p110beta	18708(Tax:10090)	74769(Tax:10090)	Gene	Gene	signals|amod|START_ENTITY isoform|nmod|signals isoform|amod|END_ENTITY	The p110beta isoform of phosphoinositide_3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma .
15388330	0	phosphoinositide_3-kinase	119,144	p85	104,107	phosphoinositide 3-kinase	p85	5295	5296	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Association of the Src_homology_2_domain-containing_leukocyte_phosphoprotein_of_76_kD -LRB- SLP-76 -RRB- with the p85 subunit of phosphoinositide_3-kinase .
16006513	0	phosphoinositide_3-kinase	110,135	p85	83,86	phosphoinositide 3-kinase	p85	18708(Tax:10090)	13601(Tax:10090)	Gene	Gene	subunits|nmod|START_ENTITY subunits|amod|END_ENTITY	Modulation of epithelial_neoplasia and lymphoid_hyperplasia in PTEN + / - mice by the p85 regulatory subunits of phosphoinositide_3-kinase .
10525402	0	phosphoinositide_3-kinase	85,110	p85alpha	54,62	phosphoinositide 3-kinase	p85alpha	5295	5295	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide_3-kinase : an SH2 domain mimicking its own substrate .
11555646	0	phosphoinositide_3-kinase	84,109	p85alpha	64,72	phosphoinositide 3-kinase	p85alpha	5295	5295	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Specific binding of the C-terminal Src homology 2 domain of the p85alpha subunit of phosphoinositide_3-kinase to phosphatidylinositol_3 ,4,5 - trisphosphate .
11752399	0	phosphoinositide_3-kinase	65,90	p85beta	46,53	phosphoinositide 3-kinase	p85beta	18708(Tax:10090)	18709(Tax:10090)	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Increased_insulin_sensitivity in mice lacking p85beta subunit of phosphoinositide_3-kinase .
16015604	0	phosphoinositol-3-kinase	20,44	EGFR	83,87	phosphoinositol-3-kinase	EGFR	5293	1956	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Independent role of phosphoinositol-3-kinase -LRB- PI3K -RRB- and casein kinase II -LRB- CK-2 -RRB- in EGFR and Her-2-mediated constitutive NF-kappaB activation in prostate_cancer cells .
11733139	0	phospholemman-like_protein	60,86	PLP	88,91	phospholemman-like protein	PLP	19227(Tax:10090)	19227(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of a novel member of the ATP1G1/PLM/MAT8 family , phospholemman-like_protein -LRB- PLP -RRB- gene , in the developmental process of mouse cerebellum .
11963834	0	phospholipase-A2	71,87	cyclooxygenase-2	37,53	phospholipase-A2	cyclooxygenase-2	151056	5743	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Site-specific augmentation of amnion cyclooxygenase-2 and decidua vera phospholipase-A2 expression in labor : possible contribution of mechanical stretch and interleukin-1 to amnion prostaglandin synthesis .
24673159	0	phospholipase_A	67,82	GPR120	90,96	phospholipase A	GPR120	57110	338557	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	The fish oil ingredient , docosahexaenoic_acid , activates cytosolic phospholipase_A via GPR120 receptor to produce prostaglandin_E and plays an anti-inflammatory role in macrophages .
9704070	0	phospholipase_A	39,54	Phospholipase_B	0,15	phospholipase A	Phospholipase B	57110	151056	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Phospholipase_B activity of a purified phospholipase_A from Vipera palestinae venom .
156639	0	phospholipase_A2	11,27	ATPase	65,71	phospholipase A2	ATPase	151056	1769	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of phospholipase_A2 and albumin on the calcium-dependent ATPase and the lipid composition of sarcoplasmic membranes .
8166641	0	phospholipase_A2	75,91	Angiotensin_II	0,14	phospholipase A2	Angiotensin II	151056	183	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates phosphorylation of high-molecular-mass cytosolic phospholipase_A2 in vascular smooth-muscle cells .
2302419	0	phospholipase_A2	46,62	Apolipoprotein_C-1	0,18	phospholipase A2	Apolipoprotein C-1	151056	341	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Apolipoprotein_C-1 inhibits the hydrolysis by phospholipase_A2 of phospholipids in liposomes and cell membranes .
10519652	0	phospholipase_A2	37,53	CNF	30,33	phospholipase A2	CNF	151056	4868	Gene	Gene	inhibitor|amod|START_ENTITY END_ENTITY|appos|inhibitor	Studies on the specificity of CNF , a phospholipase_A2 inhibitor isolated from the blood plasma of the South American rattlesnake -LRB- Crotalus durissus terrificus -RRB- .
7309712	0	phospholipase_A2	53,69	Ca2	41,44	phospholipase A2	Ca2	151056	760	Gene	Gene	+|nmod|START_ENTITY +|compound|END_ENTITY	pH dependence of the binding constant of Ca2 + to the phospholipase_A2 of A. halys blomhoffii .
21683684	0	phospholipase_A2	14,30	Hsp70	34,39	phospholipase A2	Hsp70	151056	3308	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of phospholipase_A2 by Hsp70 in vitro .
3257870	0	phospholipase_A2	24,40	Interleukin-1	0,13	phospholipase A2	Interleukin-1	151056	3552	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Interleukin-1 activates phospholipase_A2 in human synovial cells .
1575744	0	phospholipase_A2	40,56	Interleukin-1_beta	0,18	phospholipase A2	Interleukin-1 beta	151056	3553	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates cytosolic phospholipase_A2 in rheumatoid synovial fibroblasts .
2803314	0	phospholipase_A2	30,46	Interleukin-1_beta	0,18	phospholipase A2	Interleukin-1 beta	151056	100008990(Tax:9986)	Gene	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Interleukin-1_beta stimulates phospholipase_A2 mRNA synthesis in rabbit articular chondrocytes .
8185692	0	phospholipase_A2	37,53	Interleukin-1_beta	0,18	phospholipase A2	Interleukin-1 beta	151056	3553	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-1_beta induces cytosolic phospholipase_A2 and prostaglandin_H synthase in rheumatoid synovial fibroblasts .
1334462	0	phospholipase_A2	93,109	Macrophage_colony_stimulating_factor	0,36	phospholipase A2	Macrophage colony stimulating factor	151056	1435	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Macrophage_colony_stimulating_factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase_A2 .
1706672	0	phospholipase_A2	41,57	PLA2	59,63	phospholipase A2	PLA2	151056	151056	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The diagnostic value of serum pancreatic phospholipase_A2 -LRB- PLA2 -RRB- in pancreatic_diseases .
1847770	0	phospholipase_A2	71,87	PLA2	89,93	phospholipase A2	PLA2	151056	151056	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	A novel mechanism of glucocorticosteroid -LRB- GC -RRB- action in suppression of phospholipase_A2 -LRB- PLA2 -RRB- activity stimulated by Ca2 + ionophore A23187 : induction of protein phosphatases .
19747452	0	phospholipase_A2	45,61	PLA2	63,67	phospholipase A2	PLA2	151056	151056	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Assembly of an intact Golgi complex requires phospholipase_A2 -LRB- PLA2 -RRB- activity , membrane tubules , and dynein-mediated microtubule transport .
2011718	0	phospholipase_A2	28,44	PLA2	46,50	phospholipase A2	PLA2	151056	151056	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Immunoregulatory effects of phospholipase_A2 -LRB- PLA2 -RRB- on the proliferation of human lymphocytes .
2045888	0	phospholipase_A2	20,36	PLA2	38,42	phospholipase A2	PLA2	151056	151056	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Characterization of phospholipase_A2 -LRB- PLA2 -RRB- activity in gerbil brain : enhanced activities of cytosolic , mitochondrial , and microsomal forms after ischemia and reperfusion .
3115895	0	phospholipase_A2	14,30	PLA2	32,36	phospholipase A2	PLA2	18784(Tax:10090)	18784(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of phospholipase_A2 -LRB- PLA2 -RRB- activity by nifedipine and nisoldipine is independent of their calcium-channel-blocking activity .
8005604	0	phospholipase_A2	42,58	PLA2	60,64	phospholipase A2	PLA2	151056	151056	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	TaqI dimorphic site in a human pancreatic phospholipase_A2 -LRB- PLA2 -RRB- gene localized on chromosome 12 .
8234286	0	phospholipase_A2	33,49	PLA2	51,55	phospholipase A2	PLA2	151056	151056	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Inhibition of endosome fusion by phospholipase_A2 -LRB- PLA2 -RRB- inhibitors points to a role for PLA2 in endocytosis .
7542869	0	phospholipase_A2	74,90	Serum_amyloid_A_protein	0,23	phospholipase A2	Serum amyloid A protein	151056	6288	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Serum_amyloid_A_protein enhances the activity of secretory non-pancreatic phospholipase_A2 .
11137138	0	phospholipase_A2	24,40	TNF-alpha	84,93	phospholipase A2	TNF-alpha	151056	7124	Gene	Gene	effect|nmod|START_ENTITY level|nmod|effect level|nsubj|END_ENTITY	In vivo effect of snake phospholipase_A2 -LRB- crotoxin + cardiotoxin -RRB- on serum IL-1alpha , TNF-alpha and IL-1ra level in humans .
16564042	0	phospholipase_A2	10,26	TNF-alpha	53,62	phospholipase A2	TNF-alpha	18780(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Secretory phospholipase_A2 induces apoptosis through TNF-alpha and cytochrome c-mediated caspase cascade in murine macrophage RAW 264.7 cells .
1846897	0	phospholipase_A2	39,55	Tumor_necrosis_factor-alpha	0,27	phospholipase A2	Tumor necrosis factor-alpha	151056	7124	Gene	Gene	activation|amod|START_ENTITY priming|nmod|activation priming|amod|END_ENTITY	Tumor_necrosis_factor-alpha priming of phospholipase_A2 activation in human neutrophils .
3128274	0	phospholipase_A2	43,59	Tumour_necrosis_factor	0,22	phospholipase A2	Tumour necrosis factor	104974671	280943(Tax:9913)	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Tumour_necrosis_factor -LRB- cachectin -RRB- induces phospholipase_A2 activity and synthesis of a phospholipase_A2-activating protein in endothelial cells .
9099690	0	phospholipase_A2	24,40	annexin_V	44,53	phospholipase A2	annexin V	151056	308	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of cytosolic phospholipase_A2 by annexin_V in differentiated permeabilized HL-60 cells .
9425121	0	phospholipase_A2	30,46	annexin_V	56,65	phospholipase A2	annexin V	151056	308	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of human cytosolic phospholipase_A2 by human annexin_V .
15685208	0	phospholipase_A2	7,23	cPLA2	72,77	phospholipase A2	cPLA2	151056	5321	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Spinal phospholipase_A2 in inflammatory hyperalgesia : role of group IVA cPLA2 .
12381872	0	phospholipase_A2	86,102	enhancing_factor	53,69	phospholipase A2	enhancing factor	18780(Tax:10090)	18780(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|compound|END_ENTITY	Comparison of the activities of wild type and mutant enhancing_factor / mouse secretory phospholipase_A2 proteins .
1826422	0	phospholipase_A2	14,30	epidermal_growth_factor	43,66	phospholipase A2	epidermal growth factor	151056	1950	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Modulation of phospholipase_A2 activity by epidermal_growth_factor -LRB- EGF -RRB- in CHO cells transfected with human EGF_receptor .
1526278	0	phospholipase_A2	32,48	interferon-gamma	52,68	phospholipase A2	interferon-gamma	151056	3458	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|nmod|END_ENTITY	Stimulation of receptor-coupled phospholipase_A2 by interferon-gamma .
1618301	0	phospholipase_A2	9,25	interleukin-1_beta	37,55	phospholipase A2	interleukin-1 beta	151056	24494(Tax:10116)	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|fibroblasts fibroblasts|amod|END_ENTITY	Group II phospholipase_A2 induced by interleukin-1_beta in cultured rat gingival fibroblasts .
8832976	0	phospholipase_A2	48,64	interleukin-1_beta	86,104	phospholipase A2	interleukin-1 beta	151056	3553	Gene	Gene	Suppression|nmod|START_ENTITY reduces|nsubj|Suppression reduces|dobj|prostaglandin_E2 prostaglandin_E2|amod|END_ENTITY	Suppression of human synovial fibroblast 85 kDa phospholipase_A2 by antisense reduces interleukin-1_beta induced prostaglandin_E2 .
11407686	0	phospholipase_A2	26,42	macrophage_migration_inhibitory_factor	67,105	phospholipase A2	macrophage migration inhibitory factor	151056	4282	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of synoviocyte phospholipase_A2 and cyclooxygenase_2 by macrophage_migration_inhibitory_factor .
6418521	0	phospholipase_A2	81,97	melittin	55,63	phospholipase A2	melittin	104974671	406130(Tax:7460)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Stimulation of anterior pituitary prolactin release by melittin , an activator of phospholipase_A2 .
12882758	0	phospholipase_A2	64,80	nuclear_factor-kappaB	95,116	phospholipase A2	nuclear factor-kappaB	151056	4790	Gene	Gene	synthesis|amod|START_ENTITY synthesis|nmod|END_ENTITY	Surfactant_protein-A and phosphatidylglycerol suppress type IIA phospholipase_A2 synthesis via nuclear_factor-kappaB .
8380583	0	phospholipase_A2	66,82	p42	86,89	phospholipase A2	p42	151056	8814	Gene	Gene	START_ENTITY|nmod|protein protein|amod|END_ENTITY	Phosphorylation and activation of a high molecular weight form of phospholipase_A2 by p42 microtubule-associated protein 2 kinase and protein_kinase_C .
25637741	0	phospholipase_A2	18,34	peroxiredoxin_6	47,62	phospholipase A2	peroxiredoxin 6	18784(Tax:10090)	11758(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Inhibition of the phospholipase_A2 activity of peroxiredoxin_6 prevents lung_damage with exposure to hyperoxia .
17981679	0	phospholipase_A2	102,118	phospholipase_A2	161,177	phospholipase A2	phospholipase A2	151056	151056	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase_A2 receptor-mediated activation of cytosolic phospholipase_A2 .
17981679	0	phospholipase_A2	161,177	phospholipase_A2	102,118	phospholipase A2	phospholipase A2	151056	151056	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	MMP production in human fibrosarcoma cells and their invasiveness are regulated by group IB secretory phospholipase_A2 receptor-mediated activation of cytosolic phospholipase_A2 .
2945554	0	phospholipase_A2	14,30	protein_I	34,43	phospholipase A2	protein I	104974671	282689(Tax:9913)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phospholipase_A2 by protein_I .
7544805	0	phospholipase_A2	48,64	stem_cell_factor	108,124	phospholipase A2	stem cell factor	18780(Tax:10090)	17311(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Regulation of arachidonic_acid , eicosanoid , and phospholipase_A2 levels in murine mast cells by recombinant stem_cell_factor .
16330552	0	phospholipase_A2	67,83	surfactant_protein_A	15,35	phospholipase A2	surfactant protein A	151056	653509	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of surfactant_protein_A with peroxiredoxin_6 regulates phospholipase_A2 activity .
8590973	0	phospholipase_A2	108,124	transforming_growth_factor_beta_1	33,66	phospholipase A2	transforming growth factor beta 1	151056	7040	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Prostaglandin_E2 requirement for transforming_growth_factor_beta_1 inhibition of elicited macrophage 14 kDa phospholipase_A2 release .
1730604	0	phospholipase_A2	118,134	tumor_necrosis_factor	69,90	phospholipase A2	tumor necrosis factor	151056	7124	Gene	Gene	activation|nmod|START_ENTITY cause|dobj|activation END_ENTITY|acl|cause	Inhibitors of transcription and translation act synergistically with tumor_necrosis_factor to cause the activation of phospholipase_A2 .
7684376	0	phospholipase_A2	37,53	tumor_necrosis_factor	92,113	phospholipase A2	tumor necrosis factor	151056	7124	Gene	Gene	crucial|nsubj|START_ENTITY crucial|nmod|action action|nmod|END_ENTITY	Arachidonic_acid-selective cytosolic phospholipase_A2 is crucial in the cytotoxic action of tumor_necrosis_factor .
10571045	0	phospholipase_A2_activating_protein	21,56	hPLAP	58,63	phospholipase A2 activating protein	hPLAP	9373	9373	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the human phospholipase_A2_activating_protein -LRB- hPLAP -RRB- gene on the chromosome 9p21 melanoma deleted region .
22846677	0	phospholipase_A2_activating_protein	74,109	miR-203	0,7	phospholipase A2 activating protein	miR-203	18786(Tax:10090)	387199(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	miR-203 regulates nociceptive sensitization after incision by controlling phospholipase_A2_activating_protein expression .
23609358	0	phospholipase_A2_group_IIA	25,51	PLA2G2A	53,60	phospholipase A2 group IIA	PLA2G2A	5320	5320	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical significance of phospholipase_A2_group_IIA -LRB- PLA2G2A -RRB- expression in primary resected esophageal_squamous_cell_carcinoma .
19892737	0	phospholipase_C	26,41	Ceramide_kinase	0,15	phospholipase C	Ceramide kinase	31376(Tax:7227)	40640(Tax:7227)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Ceramide_kinase regulates phospholipase_C and phosphatidylinositol 4 , 5 , bisphosphate in phototransduction .
18184564	0	phospholipase_C	84,99	STOPS	21,26	phospholipase C	STOPS	31376(Tax:7227)	43683(Tax:7227)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase_C .
1513321	0	phospholipase_C-alpha	57,78	angiotensin_II	27,41	phospholipase C-alpha	angiotensin II	14827(Tax:10090)	11606(Tax:10090)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|receptors receptors|compound|END_ENTITY	Association of solubilized angiotensin_II receptors with phospholipase_C-alpha in murine neuroblastoma NIE-115 cells .
9685362	0	phospholipase_C-beta1	14,35	calcitonin_gene-related_peptide	82,113	phospholipase C-beta1	calcitonin gene-related peptide	23236	796	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of phospholipase_C-beta1 via Galphaq/11 during calcium mobilization by calcitonin_gene-related_peptide .
12716374	0	phospholipase_C-beta2	20,41	PAR1	94,98	phospholipase C-beta2	PAR1	5330	2149	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Role of Galphaq and phospholipase_C-beta2 in human platelets activation by thrombin receptors PAR1 and PAR4 : studies in human platelets_deficient in Galphaq and phospholipase_C-beta2 .
15322077	0	phospholipase_C-epsilon	24,47	RhoA	0,4	phospholipase C-epsilon	RhoA	5334	387	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	RhoA activates purified phospholipase_C-epsilon by a guanine_nucleotide-dependent mechanism .
16038803	0	phospholipase_C-gamma1	58,80	Grb2	0,4	phospholipase C-gamma1	Grb2	5335	2885	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Grb2 negatively regulates epidermal_growth_factor-induced phospholipase_C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase_C-gamma1 .
16000869	0	phospholipase_C-gamma1	46,68	PLC	95,98	phospholipase C-gamma1	PLC	5335	3339	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Inositol 5 ' - phosphatase , SHIP1 interacts with phospholipase_C-gamma1 and modulates EGF-induced PLC activity .
11409699	0	phospholipase_C-gamma1	4,26	PLCG1	33,38	phospholipase C-gamma1	PLCG1	5335	5335	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The phospholipase_C-gamma1 gene -LRB- PLCG1 -RRB- and lithium-responsive bipolar_disorder : re-examination of an intronic dinucleotide repeat polymorphism .
12061819	0	phospholipase_C-gamma1	29,51	c-Cbl	57,62	phospholipase C-gamma1	c-Cbl	18803(Tax:10090)	12402(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	EGF-dependent association of phospholipase_C-gamma1 with c-Cbl .
16038803	0	phospholipase_C-gamma1	150,172	phospholipase_C-gamma1	58,80	phospholipase C-gamma1	phospholipase C-gamma1	5335	5335	Gene	Gene	interaction|nmod|START_ENTITY regulates|nmod|interaction regulates|dobj|activity activity|amod|END_ENTITY	Grb2 negatively regulates epidermal_growth_factor-induced phospholipase_C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase_C-gamma1 .
16038803	0	phospholipase_C-gamma1	58,80	phospholipase_C-gamma1	150,172	phospholipase C-gamma1	phospholipase C-gamma1	5335	5335	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nmod|interaction interaction|nmod|END_ENTITY	Grb2 negatively regulates epidermal_growth_factor-induced phospholipase_C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase_C-gamma1 .
15872086	0	phospholipase_C-gamma1	136,158	src	60,63	phospholipase C-gamma1	src	5335	6714	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Calcium-induced human keratinocyte differentiation requires src - and fyn-mediated phosphatidylinositol_3-kinase-dependent activation of phospholipase_C-gamma1 .
7673364	0	phospholipase_C-gamma_1	67,90	Epidermal_growth_factor	0,23	phospholipase C-gamma 1	Epidermal growth factor	5335	1950	Gene	Gene	association|nmod|START_ENTITY induces|dobj|association induces|nsubj|END_ENTITY	Epidermal_growth_factor induces rapid and transient association of phospholipase_C-gamma_1 with EGF-receptor and filamentous actin at membrane ruffles of A431 cells .
8034732	0	phospholipase_C-gamma_1	66,89	Erythropoietin	0,14	phospholipase C-gamma 1	Erythropoietin	5335	2056	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Erythropoietin induces tyrosine phosphorylation and activation of phospholipase_C-gamma_1 in a human erythropoietin-dependent cell line .
9573541	0	phospholipase_C-gamma_1	62,85	Erythropoietin	0,14	phospholipase C-gamma 1	Erythropoietin	5335	2056	Gene	Gene	activation|nmod|START_ENTITY channels|dep|activation channels|amod|END_ENTITY	Erythropoietin receptor-operated Ca2 + channels : activation by phospholipase_C-gamma_1 .
7688472	0	phospholipase_C-gamma_1	40,63	LFA-1	16,21	phospholipase C-gamma 1	LFA-1	5335	3683	Gene	Gene	activation|amod|START_ENTITY signaling|nmod|activation END_ENTITY|acl|signaling	Beta_2-integrin LFA-1 signaling through phospholipase_C-gamma_1 activation .
1533389	0	phospholipase_C-gamma_1	26,49	PLC_gamma_1	51,62	phospholipase C-gamma 1	PLC gamma 1	5335	5335	Gene	Gene	tyrosine|amod|START_ENTITY tyrosine|appos|END_ENTITY	Regulation of CD3-induced phospholipase_C-gamma_1 -LRB- PLC_gamma_1 -RRB- tyrosine phosphorylation by CD4 and CD45 receptors .
7541047	0	phospholipase_C-gamma_1	82,105	angiotensin_II	53,67	phospholipase C-gamma 1	angiotensin II	25738(Tax:10116)	24179(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|amod|END_ENTITY	Electroporation of pp60c-src antibodies inhibits the angiotensin_II activation of phospholipase_C-gamma_1 in rat aortic smooth muscle cells .
8119714	0	phospholipase_C-gamma_1	56,79	epidermal_growth_factor_receptor	4,36	phospholipase C-gamma 1	epidermal growth factor receptor	5335	1956	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The epidermal_growth_factor_receptor is associated with phospholipase_C-gamma_1 in meningiomas .
7691952	1	phospholipase_C-gamma_1_and_PLC_phospholipase_C-gamma_2	146,201	CD20	95,99	phospholipase C-gamma 1 and PLC phospholipase C-gamma 2	CD20	5335	54474	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction via CD20 of tyrosine phosphorylation and activation of phospholipase_C-gamma_1_and_PLC_phospholipase_C-gamma_2 .
11128920	0	phospholipase_C_beta1	26,47	Cyclosporin_A	0,13	phospholipase C beta1	Cyclosporin A	23236	1161	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Cyclosporin_A upregulates phospholipase_C_beta1 in fibroblasts from gingival_overgrowth .
9003510	0	phospholipase_C_beta_3	43,65	PLCB3	67,72	phospholipase C beta 3	PLCB3	5331	5331	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Exclusion of the phosphoinositide-specific phospholipase_C_beta_3 -LRB- PLCB3 -RRB- gene as a candidate for multiple_endocrine_neoplasia_type_1 .
9535722	0	phospholipase_C_gamma-1	42,65	IRS-2	76,81	phospholipase C gamma-1	IRS-2	5335	8660	Gene	Gene	association|amod|START_ENTITY association|compound|END_ENTITY	IL-13 induces tyrosine phosphorylation of phospholipase_C_gamma-1 following IRS-2 association in human monocytes : relationship with the inhibitory effect of IL-13 on ROI production .
14704368	0	phospholipase_C_gamma2	45,67	MerTK	29,34	phospholipase C gamma2	MerTK	234779(Tax:10090)	17289(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The receptor tyrosine kinase MerTK activates phospholipase_C_gamma2 during recognition of apoptotic thymocytes by murine macrophages .
9600070	0	phospholipase_C_gamma_1	93,116	Bradykinin	0,10	phospholipase C gamma 1	Bradykinin	5335	3827	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Bradykinin stimulates the tyrosine phosphorylation and bradykinin B2_receptor association of phospholipase_C_gamma_1 in vascular endothelial cells .
8492120	0	phospholipase_C_gamma_1	25,48	brain-derived_neurotrophic_factor	52,85	phospholipase C gamma 1	brain-derived neurotrophic factor	25738(Tax:10116)	24225(Tax:10116)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Rapid phosphorylation of phospholipase_C_gamma_1 by brain-derived_neurotrophic_factor and neurotrophin-3 in cultures of embryonic rat cortical neurons .
23555801	0	phospholipase_C_gamma_2	26,49	BANK1	0,5	phospholipase C gamma 2	BANK1	5336	55024	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	BANK1 and BLK act through phospholipase_C_gamma_2 in B-cell signaling .
12049640	0	phospholipase_Cgamma2	100,121	glycoprotein_VI	61,76	phospholipase Cgamma2	glycoprotein VI	5336	51206	Gene	Gene	regulation|amod|START_ENTITY regulation|amod|END_ENTITY	Differential role of glycolipid-enriched membrane domains in glycoprotein_VI - and integrin-mediated phospholipase_Cgamma2 regulation in platelets .
16113073	0	phospholipase_D	18,33	ANG	0,3	phospholipase D	ANG	2822	283	Gene	Gene	START_ENTITY|nsubj|stimulates stimulates|compound|END_ENTITY	ANG II stimulates phospholipase_D through PKCzeta activation in VSMC : implications in adhesion , spreading , and hypertrophy .
21135091	0	phospholipase_D	61,76	Age1	40,44	phospholipase D	Age1	853902(Tax:4932)	852136(Tax:4932)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase_D for post-Golgi vesicular transport .
9973479	0	phospholipase_D	158,173	Beta_1_integrin	0,15	phospholipase D	Beta 1 integrin	2822	3688	Gene	Gene	role|nmod|START_ENTITY activity|dep|role activity|amod|END_ENTITY	Beta_1_integrin cross-linking inhibits CD16-induced phospholipase_D and secretory phospholipase A2 activity and granule exocytosis in human NK cells : role of phospholipase_D in CD16-triggered degranulation .
9973479	0	phospholipase_D	52,67	Beta_1_integrin	0,15	phospholipase D	Beta 1 integrin	2822	3688	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Beta_1_integrin cross-linking inhibits CD16-induced phospholipase_D and secretory phospholipase A2 activity and granule exocytosis in human NK cells : role of phospholipase_D in CD16-triggered degranulation .
11419696	0	phospholipase_D	60,75	Bradykinin	0,10	phospholipase D	Bradykinin	2822	3827	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Bradykinin induces protein kinase C-dependent activation of phospholipase_D in A-431 cells .
2307846	0	phospholipase_D	29,44	C5a	11,14	phospholipase D	C5a	2822	728	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Complement C5a activation of phospholipase_D in human neutrophils .
17627030	0	phospholipase_D	23,38	CCR5	0,4	phospholipase D	CCR5	2822	1234	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	CCR5 signaling through phospholipase_D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression .
20693286	0	phospholipase_D	32,47	ERK1/2	63,69	phospholipase D	ERK1/2	2822	5595;5594	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Protein_kinase_B -LRB- AKT -RRB- mediates phospholipase_D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells .
9624189	0	phospholipase_D	64,79	HARL1	129,134	phospholipase D	HARL1	2822	400	Gene	Gene	START_ENTITY|nmod|protein protein|appos|END_ENTITY	Phospholipid - and GTP-dependent activation of cholera_toxin and phospholipase_D by human ADP-ribosylation factor-like protein 1 -LRB- HARL1 -RRB- .
8178956	0	phospholipase_D	52,67	Interleukin-1	0,13	phospholipase D	Interleukin-1	2822	3552	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Interleukin-1 stimulates phosphatidic_acid-mediated phospholipase_D activity in human mesangial cells .
7882615	0	phospholipase_D	8,23	MMP-2	71,76	phospholipase D	MMP-2	2822	4313	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of phospholipase_D in laminin-induced production of gelatinase A -LRB- MMP-2 -RRB- in metastatic cells .
24009738	0	phospholipase_D	12,27	MTOR	46,50	phospholipase D	MTOR	2822	2475	Gene	Gene	START_ENTITY|advcl|modulating modulating|dobj|END_ENTITY	The role of phospholipase_D in modulating the MTOR signaling pathway in polycystic_kidney_disease .
14744865	0	phospholipase_D	19,34	Munc-18-1	0,9	phospholipase D	Munc-18-1	2822	6812	Gene	Gene	START_ENTITY|nsubj|inhibits inhibits|compound|END_ENTITY	Munc-18-1 inhibits phospholipase_D activity by direct interaction in an epidermal_growth_factor-reversible manner .
16113073	0	phospholipase_D	18,33	PKCzeta	42,49	phospholipase D	PKCzeta	2822	5590	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	ANG II stimulates phospholipase_D through PKCzeta activation in VSMC : implications in adhesion , spreading , and hypertrophy .
17431093	0	phospholipase_D	14,29	PLD	54,57	phospholipase D	PLD	2822	2822	Gene	Gene	START_ENTITY|dep|involvement involvement|compound|END_ENTITY	Understanding phospholipase_D -LRB- PLD -RRB- using leukocytes : PLD involvement in cell adhesion and chemotaxis .
24590739	0	phospholipase_D	42,57	PLD	59,62	phospholipase D	PLD	2822	2822	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Cloning and molecular characterization of phospholipase_D -LRB- PLD -RRB- delta gene from longan -LRB- Dimocarpus longan Lour . -RRB- .
8753790	0	phospholipase_D	32,47	PLD	49,52	phospholipase D	PLD	2822	2822	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential mRNA expression of phospholipase_D -LRB- PLD -RRB- isozymes during cAMP-induced differentiation in C6 glioma cells .
9145335	0	phospholipase_D	164,179	PLD	181,184	phospholipase D	PLD	2822	2822	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Differential expression of protein kinase C isozymes and small GTP-binding proteins during HL60 cell differentiation by retinoic_acid and cyclic_AMP : relation with phospholipase_D -LRB- PLD -RRB- activation .
9512645	0	phospholipase_D	29,44	PLD	46,49	phospholipase D	PLD	2822	2822	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased mRNA expression of phospholipase_D -LRB- PLD -RRB- isozymes during granulocytic differentiation of HL60 cells .
9642212	0	phospholipase_D	11,26	Pld1p	28,33	phospholipase D	Pld1p	853902(Tax:4932)	853902(Tax:4932)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for phospholipase_D -LRB- Pld1p -RRB- in growth , secretion , and regulation of membrane lipid synthesis in yeast .
20693286	0	phospholipase_D	32,47	Protein_kinase_B	0,16	phospholipase D	Protein kinase B	2822	2185	Gene	Gene	activation|amod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Protein_kinase_B -LRB- AKT -RRB- mediates phospholipase_D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells .
9469451	0	phospholipase_D	21,36	RANTES	0,6	phospholipase D	RANTES	2822	6352	Gene	Gene	cells|amod|START_ENTITY activation|nmod|cells activation|compound|END_ENTITY	RANTES activation of phospholipase_D in Jurkat T cells : requirement of GTP-binding proteins ARF and RhoA .
8955215	0	phospholipase_D	61,76	THP-1	135,140	phospholipase D	THP-1	2822	2736	Gene	Gene	START_ENTITY|nmod|line line|compound|END_ENTITY	Induction of the P2z/P2X7 nucleotide receptor and associated phospholipase_D activity by lipopolysaccharide and IFN-gamma in the human THP-1 monocytic cell line .
9873818	0	phospholipase_D	11,26	TNF-alpha	39,48	phospholipase D	TNF-alpha	2822	7124	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Changes of phospholipase_D activity in TNF-alpha and anti-Fas/Apo1 monoclonal antibody induced apoptosis in HL-60 and A20 cells .
8804365	0	phospholipase_D	73,88	Vascular_endothelial_growth_factor	0,34	phospholipase D	Vascular endothelial growth factor	2822	7422	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor stimulates protein kinase C-dependent phospholipase_D activity in endothelial cells .
7698316	0	phospholipase_D	69,84	bombesin	32,40	phospholipase D	bombesin	2822	2922	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Heterologous desensitization of bombesin - and vasopressin-stimulated phospholipase_D activity in Swiss 3T3 fibroblasts .
8753774	0	phospholipase_D	145,160	bradykinin	119,129	phospholipase D	bradykinin	2822	3827	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Activation of phospholipase_D in human fibroblasts by ceramide and sphingosine : evaluation of their modulatory role in bradykinin stimulation of phospholipase_D .
7812007	0	phospholipase_D	165,180	interleukin-8	111,124	phospholipase D	interleukin-8	2822	3576	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils : interleukin-8 , but not NAP-2 or GRO_alpha , stimulates phospholipase_D activity .
11550712	0	phospholipase_D	66,81	interleukin_1	10,23	phospholipase D	interleukin 1	2822	3552	Gene	Gene	activity|amod|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of interleukin_1 , lipopolysaccharide and phorbol_esters on phospholipase_D activity in chondrocytes .
15580312	0	phospholipase_D	12,27	mTOR	28,32	phospholipase D	mTOR	2822	21977(Tax:10090)	Gene	Gene	signal|dep|START_ENTITY signal|compound|END_ENTITY	Alternative phospholipase_D / mTOR survival signal in human breast_cancer cells .
16537399	0	phospholipase_D	12,27	mTOR	82,86	phospholipase D	mTOR	2822	21977(Tax:10090)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	The role of phospholipase_D and phosphatidic_acid in the mechanical activation of mTOR signaling in skeletal muscle .
9973479	0	phospholipase_D	158,173	phospholipase_D	52,67	phospholipase D	phospholipase D	2822	2822	Gene	Gene	role|nmod|START_ENTITY activity|dep|role activity|amod|END_ENTITY	Beta_1_integrin cross-linking inhibits CD16-induced phospholipase_D and secretory phospholipase A2 activity and granule exocytosis in human NK cells : role of phospholipase_D in CD16-triggered degranulation .
9973479	0	phospholipase_D	52,67	phospholipase_D	158,173	phospholipase D	phospholipase D	2822	2822	Gene	Gene	activity|amod|START_ENTITY activity|dep|role role|nmod|END_ENTITY	Beta_1_integrin cross-linking inhibits CD16-induced phospholipase_D and secretory phospholipase A2 activity and granule exocytosis in human NK cells : role of phospholipase_D in CD16-triggered degranulation .
23178798	0	phospholipase_D	11,26	protein_kinase_D	53,69	phospholipase D	protein kinase D	2822	5587	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|amod|END_ENTITY	A role for phospholipase_D in angiotensin_II-induced protein_kinase_D activation in adrenal glomerulosa cell models .
10919268	0	phospholipase_D-1	28,45	Interleukin-1beta	0,17	phospholipase D-1	Interleukin-1beta	25096(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-1beta regulates phospholipase_D-1 expression in rat pancreatic beta-cells .
9688545	0	phospholipase_D1	14,30	ADP-ribosylation_factor_1	58,83	phospholipase D1	ADP-ribosylation factor 1	5337	375	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of phospholipase_D1 by direct interaction with ADP-ribosylation_factor_1 and RalA .
16716806	0	phospholipase_D1	67,83	CD11c	46,51	phospholipase D1	CD11c	5337	3687	Gene	Gene	activation|amod|START_ENTITY expression|nmod|activation expression|amod|END_ENTITY	Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase_D1 activation in U937 cells .
25047119	0	phospholipase_D1	57,73	Leptin	0,6	phospholipase D1	Leptin	18805(Tax:10090)	16846(Tax:10090)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Leptin increases TNF-a expression and production through phospholipase_D1 in Raw 264.7 cells .
23793974	0	phospholipase_D1	59,75	P2X7_receptor	28,41	phospholipase D1	P2X7 receptor	5337	5027	Gene	Gene	stimulation|amod|START_ENTITY END_ENTITY|nmod|stimulation	CAY10593 inhibits the human P2X7_receptor independently of phospholipase_D1 stimulation .
11259428	0	phospholipase_D1	14,30	PKN	0,3	phospholipase D1	PKN	5337	5585	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	PKN regulates phospholipase_D1 through direct interaction .
16045763	0	phospholipase_D1	69,85	Peroxiredoxin_II	0,16	phospholipase D1	Peroxiredoxin II	5337	7001	Gene	Gene	functions|nmod|START_ENTITY functions|compound|END_ENTITY	Peroxiredoxin_II functions as a signal terminator for H2O2-activated phospholipase_D1 .
16449386	0	phospholipase_D1	18,34	Presenilin-1	0,12	phospholipase D1	Presenilin-1	5337	5663	Gene	Gene	uses|dobj|START_ENTITY uses|nsubj|END_ENTITY	Presenilin-1 uses phospholipase_D1 as a negative regulator of beta-amyloid formation .
10037681	0	phospholipase_D1	69,85	RhoA	35,39	phospholipase D1	RhoA	5337	387	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the small G protein RhoA with the C terminus of human phospholipase_D1 .
15150446	0	phospholipase_D1	19,35	RhoA	79,83	phospholipase D1	RhoA	5337	387	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|interaction interaction|nmod|END_ENTITY	Phosphorylation of phospholipase_D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase .
26763395	0	phospholipase_D1	73,89	interleukin-6	32,45	phospholipase D1	interleukin-6	5337	3569	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|amod|END_ENTITY	Cigarette smoke extract-induced interleukin-6 expression is regulated by phospholipase_D1 in human bronchial epithelial cells .
12782287	0	phospholipase_D1	76,92	p21	64,67	phospholipase D1	p21	18805(Tax:10090)	12575(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|dobj|gene gene|amod|END_ENTITY	Transcriptional repression of cyclin-dependent kinase inhibitor p21 gene by phospholipase_D1 and D2 .
21284604	0	phospholipase_D1	62,78	progesterone_receptor	4,25	phospholipase D1	progesterone receptor	5337	5241	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The progesterone_receptor as a transcription factor regulates phospholipase_D1 expression through independent activation of protein kinase A and Ras during 8-Br-cAMP-induced decidualization in human endometrial stromal cells .
25432699	0	phospholipase_D2	64,80	Hypoxia-inducible_factor_1-alpha	0,32	phospholipase D2	Hypoxia-inducible factor 1-alpha	5338	3091	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor_1-alpha up-regulates the expression of phospholipase_D2 in colon_cancer cells under hypoxic conditions .
12890682	0	phospholipase_D2	15,31	platelet-derived_growth_factor_receptor-beta	80,124	phospholipase D2	platelet-derived growth factor receptor-beta	5338	5159	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of phospholipase_D2 in lysophosphatidate-induced transactivation of platelet-derived_growth_factor_receptor-beta in human bronchial epithelial cells .
12009895	0	phospholipid_scramblase_1	16,41	epidermal_growth_factor_receptor	92,124	phospholipid scramblase 1	epidermal growth factor receptor	5359	1956	Gene	Gene	enriched|nsubjpass|START_ENTITY enriched|nmod|END_ENTITY	Plasma membrane phospholipid_scramblase_1 is enriched in lipid rafts and interacts with the epidermal_growth_factor_receptor .
12871937	0	phospholipid_scramblase_1	16,41	epidermal_growth_factor_receptor	97,129	phospholipid scramblase 1	epidermal growth factor receptor	22038(Tax:10090)	13649(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Plasma membrane phospholipid_scramblase_1 promotes EGF-dependent activation of c-Src through the epidermal_growth_factor_receptor .
16611984	0	phospholipid_scramblase_1	102,127	onzin	26,31	phospholipid scramblase 1	onzin	5359	51316	Gene	Gene	affects|nmod|START_ENTITY affects|nsubj|END_ENTITY	The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid_scramblase_1 .
24532668	0	phospholipid_transfer_protein	27,56	Cathepsin_G	0,11	phospholipid transfer protein	Cathepsin G	18830(Tax:10090)	13035(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Cathepsin_G degradation of phospholipid_transfer_protein -LRB- PLTP -RRB- augments pulmonary_inflammation .
19627602	0	phospholipid_transfer_protein	21,50	Haptoglobin	0,11	phospholipid transfer protein	Haptoglobin	5360	3240	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Haptoglobin inhibits phospholipid_transfer_protein activity in hyperlipidemic human plasma .
11254896	0	phospholipid_transfer_protein	14,43	PLTP	45,49	phospholipid transfer protein	PLTP	5360	5360	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	The impact of phospholipid_transfer_protein -LRB- PLTP -RRB- on HDL metabolism .
11566452	0	phospholipid_transfer_protein	19,48	PLTP	50,54	phospholipid transfer protein	PLTP	5360	5360	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of plasma phospholipid_transfer_protein -LRB- PLTP -RRB- in HDL remodeling in acute-phase patients .
17437182	0	phospholipid_transfer_protein	24,53	PLTP	98,102	phospholipid transfer protein	PLTP	18830(Tax:10090)	18830(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|effects effects|nmod|END_ENTITY	Inducible expression of phospholipid_transfer_protein -LRB- PLTP -RRB- in transgenic_mice : acute effects of PLTP on lipoprotein metabolism .
24532668	0	phospholipid_transfer_protein	27,56	PLTP	58,62	phospholipid transfer protein	PLTP	18830(Tax:10090)	18830(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	Cathepsin_G degradation of phospholipid_transfer_protein -LRB- PLTP -RRB- augments pulmonary_inflammation .
24842896	0	phospholipid_transfer_protein	82,111	serum_amyloid_A	50,65	phospholipid transfer protein	serum amyloid A	5360	6287	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	Polycystic_ovary_syndrome influences the level of serum_amyloid_A and activity of phospholipid_transfer_protein in HDL and HDL .
10429369	0	phosphomannomutase_2	64,84	PMM2	86,90	phosphomannomutase 2	PMM2	5373	5373	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An AciI polymorphism in the 3 ' untranslated region of the human phosphomannomutase_2 -LRB- PMM2 -RRB- gene .
9887379	0	phosphomannomutase_2	24,44	PMM2	46,50	phosphomannomutase 2	PMM2	5373	5373	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detailed mapping of the phosphomannomutase_2 -LRB- PMM2 -RRB- gene and mutation detection enable improved analysis for Scandinavian CDG type I families .
9600238	0	phosphorylase_kinase	103,123	PHKA2	124,129	phosphorylase kinase	PHKA2	5256	5256	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Variability of biochemical and clinical phenotype in X-linked_liver_glycogenosis with mutations in the phosphorylase_kinase PHKA2 gene .
11796108	0	phosphorylase_kinase	31,51	glycogen_phosphorylase_b	92,116	phosphorylase kinase	glycogen phosphorylase b	5256	5834	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Three-dimensional structure of phosphorylase_kinase at 22 A resolution and its complex with glycogen_phosphorylase_b .
23237778	0	phosphotyrosine_interaction_domain_containing_1	49,96	PID1	98,102	phosphotyrosine interaction domain containing 1	PID1	102171387	102171387	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and tissue distribution of the phosphotyrosine_interaction_domain_containing_1 -LRB- PID1 -RRB- gene in Tianfu goat .
11940579	0	phosphotyrosine_phosphatase	57,84	Insulin-like_growth_factor-binding_protein-3	0,44	phosphotyrosine phosphatase	Insulin-like growth factor-binding protein-3	995	3486	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Insulin-like_growth_factor-binding_protein-3 activates a phosphotyrosine_phosphatase .
8264566	0	phosphotyrosine_phosphatase	17,44	PTPase	46,52	phosphotyrosine phosphatase	PTPase	995	995	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Determination of phosphotyrosine_phosphatase -LRB- PTPase -RRB- activity in normal and transformed cells .
8635665	0	phosphotyrosine_phosphatase	26,53	PTPase	55,61	phosphotyrosine phosphatase	PTPase	995	995	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Decreased skeletal muscle phosphotyrosine_phosphatase -LRB- PTPase -RRB- activity towards insulin_receptors in insulin-resistant Zucker rats measured by delayed Europium fluorescence .
229914	0	phosvitin	53,62	cytochrome_c	15,27	phosvitin	cytochrome c	1460	54205	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of cytochrome_c with the phosphorprotein phosvitin .
2992394	0	phosvitin	68,77	cytochrome_c	27,39	phosvitin	cytochrome c	1460	54205	Gene	Gene	bound|nmod|START_ENTITY bound|nsubj|Oxidation Oxidation|nmod|END_ENTITY	Oxidation and reduction of cytochrome_c bound to the phosphoprotein phosvitin .
21666806	0	phot1	0,5	ABCB19	20,26	phot1	ABCB19	823721(Tax:3702)	822519(Tax:3702)	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	phot1 inhibition of ABCB19 primes lateral auxin fluxes in the shoot apex required for phototropism .
19086271	0	photoreceptor_cell-specific_nuclear_receptor	58,102	DHR51	0,5	photoreceptor cell-specific nuclear receptor	DHR51	10002	36702(Tax:7227)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	DHR51 , the Drosophila_melanogaster homologue of the human photoreceptor_cell-specific_nuclear_receptor , is a thiolate heme-binding protein .
11071390	0	photoreceptor_cell-specific_nuclear_receptor	4,48	PNR	55,58	photoreceptor cell-specific nuclear receptor	PNR	10002	10002	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The photoreceptor_cell-specific_nuclear_receptor gene -LRB- PNR -RRB- accounts for retinitis_pigmentosa in the Crypto-Jews from Portugal -LRB- Marranos -RRB- , survivors from the Spanish Inquisition .
23196397	0	phototropin2	30,42	LOV1	5,9	phototropin2	LOV1	835926(Tax:3702)	837635(Tax:3702)	Gene	Gene	domains|nmod|START_ENTITY domains|compound|END_ENTITY	Both LOV1 and LOV2 domains of phototropin2 function as the photosensory domain for hypocotyl phototropic responses in Arabidopsis_thaliana -LRB- Brassicaceae -RRB- .
12732216	0	phox	47,51	p47	43,46	phox	p47	5341	5341	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Differentiation-dependent up-regulation of p47 -LRB- phox -RRB- gene transcription is associated with changes in PU .1 phosphorylation and increased binding affinity .
16752909	0	phox	110,114	p47	106,109	phox	p47	5341	5341	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Small-angle X-ray scattering reveals an extended organization for the autoinhibitory resting state of the p47 -LRB- phox -RRB- modular protein .
17922419	0	phox	49,53	p47	45,48	phox	p47	5341	5341	Gene	Gene	polymorphism|appos|START_ENTITY polymorphism|amod|END_ENTITY	-LSB- The relationship between the exon 10 of the p47 -LRB- phox -RRB- polymorphism and stroke and the effect of the polymorphism on plasma lipid -RSB- .
23017837	0	phytochelatin_synthase	30,52	TaPCS1	59,65	phytochelatin synthase	TaPCS1	542834(Tax:4565)	542834(Tax:4565)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Heteroexpression of the wheat phytochelatin_synthase gene -LRB- TaPCS1 -RRB- in rice enhances cadmium sensitivity .
11889039	0	phytochrome_A	31,44	FAR1	114,118	phytochrome A	FAR1	837483(Tax:3702)	827173(Tax:3702)	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|interacting interacting|nmod|END_ENTITY	Arabidopsis FHY3 defines a key phytochrome_A signaling component directly interacting with its homologous partner FAR1 .
9881166	0	phytochrome_A_and_B	64,83	cryptochrome_1	24,38	phytochrome A and B	cryptochrome 1	837483;816394	826470(Tax:3702)	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	The blue light receptor cryptochrome_1 can act independently of phytochrome_A_and_B in Arabidopsis_thaliana .
24908267	0	phytochrome_B	38,51	CONSTANS-LIKE_7	0,15	phytochrome B	CONSTANS-LIKE 7	816394(Tax:3702)	831441(Tax:3702)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	CONSTANS-LIKE_7 -LRB- COL7 -RRB- is involved in phytochrome_B -LRB- phyB -RRB- - mediated light-quality regulation of auxin homeostasis .
19165330	0	phytochrome_B	48,61	PIF3	128,132	phytochrome B	PIF3	816394(Tax:3702)	837479(Tax:3702)	Gene	Gene	knot|nmod|START_ENTITY clustered|nmod|knot Residues|acl|clustered necessary|nsubj|Residues necessary|advcl|binding binding|advcl|signaling signaling|dobj|END_ENTITY	Residues clustered in the light-sensing knot of phytochrome_B are necessary for conformer-specific binding to signaling partner PIF3 .
17251203	0	phytochrome_B	43,56	phytochrome_B	81,94	phytochrome B	phytochrome B	816394(Tax:3702)	816394(Tax:3702)	Gene	Gene	START_ENTITY|nmod|interactions interactions|nmod|END_ENTITY	Roles for the N - and C-terminal domains of phytochrome_B in interactions between phytochrome_B and cryptochrome signaling cascades .
17251203	0	phytochrome_B	81,94	phytochrome_B	43,56	phytochrome B	phytochrome B	816394(Tax:3702)	816394(Tax:3702)	Gene	Gene	interactions|nmod|START_ENTITY END_ENTITY|nmod|interactions	Roles for the N - and C-terminal domains of phytochrome_B in interactions between phytochrome_B and cryptochrome signaling cascades .
22241480	0	phytoene_synthase	25,42	PSY	44,47	phytoene synthase	PSY	106371962	106371962	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Retention of triplicated phytoene_synthase -LRB- PSY -RRB- genes in Brassica_napus_L .
25454784	0	pickpocket	16,26	Balboa	0,6	pickpocket	Balboa	34843(Tax:7227)	38835(Tax:7227)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Balboa binds to pickpocket in vivo and is required for mechanical nociception in Drosophila larvae .
12603742	0	pif	95,98	pSAM2_immunity_factor	105,126	pif	pSAM2 immunity factor	117159	117159	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Conjugal immunity of Streptomyces strains carrying the integrative element pSAM2 is due to the pif gene -LRB- pSAM2_immunity_factor -RRB- .
20637211	0	pigment-dispersing_hormone	60,86	PDH	88,91	pigment-dispersing hormone	PDH	43193(Tax:7227)	43193(Tax:7227)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Precursor structure , distribution and possible functions of pigment-dispersing_hormone -LRB- PDH -RRB- in the terrestrial isopod Armadillidium vulgare -LRB- Latreille -RRB- .
10531367	0	pigment_epithelium-derived_factor	11,44	PEDF	46,50	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of pigment_epithelium-derived_factor -LRB- PEDF -RRB- to retinoblastoma cells and cerebellar granule neurons .
18677713	0	pigment_epithelium-derived_factor	16,49	PEDF	51,55	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are positively associated with visceral adiposity in Japanese patients with type 2 diabetes .
19073347	0	pigment_epithelium-derived_factor	16,49	PEDF	51,55	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are an independent determinant of insulin resistance in patients with essential hypertension .
19275665	0	pigment_epithelium-derived_factor	31,64	PEDF	66,70	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	Atheroprotective properties of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in cardiometabolic_disorders .
19685553	0	pigment_epithelium-derived_factor	19,52	PEDF	54,58	pigment epithelium-derived factor	PEDF	57104	287526(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Protective role of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in early phase of experimental diabetic_retinopathy .
20423314	0	pigment_epithelium-derived_factor	27,60	PEDF	62,66	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Pathophysiological role of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in hepatic_disorders .
22288782	0	pigment_epithelium-derived_factor	16,49	PEDF	51,55	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are positively associated with acanthosis nigricans in obese adolescents .
22547263	0	pigment_epithelium-derived_factor	53,86	PEDF	88,92	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Insulin resistance is associated with elevated serum pigment_epithelium-derived_factor -LRB- PEDF -RRB- levels in morbidly obese patients .
22884488	0	pigment_epithelium-derived_factor	16,49	PEDF	51,55	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are independently associated with procollagen III N-terminal peptide levels in patients with nonalcoholic_fatty_liver_disease .
23075882	0	pigment_epithelium-derived_factor	23,56	PEDF	58,62	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Hormonal regulation of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in granulosa cells .
23229538	0	pigment_epithelium-derived_factor	8,41	PEDF	43,47	pigment epithelium-derived factor	PEDF	287526(Tax:10116)	287526(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of pigment_epithelium-derived_factor -LRB- PEDF -RRB- in arsenic-induced cell apoptosis of liver and brain in a rat model .
23884140	0	pigment_epithelium-derived_factor	25,58	PEDF	60,64	pigment epithelium-derived factor	PEDF	20317(Tax:10090)	20317(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Protective role of small pigment_epithelium-derived_factor -LRB- PEDF -RRB- peptide in diabetic_renal_injury .
23887690	0	pigment_epithelium-derived_factor	47,80	PEDF	82,86	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Determination of mesenchymal stem cell fate by pigment_epithelium-derived_factor -LRB- PEDF -RRB- results in increased adiposity and reduced bone mineral content .
24769282	0	pigment_epithelium-derived_factor	23,56	PEDF	58,62	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hormonal regulation of pigment_epithelium-derived_factor -LRB- PEDF -RRB- expression in the endometrium .
25705004	0	pigment_epithelium-derived_factor	16,49	PEDF	51,55	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of pigment_epithelium-derived_factor -LRB- PEDF -RRB- are inversely associated with circulating levels of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- in humans .
8976566	0	pigment_epithelium-derived_factor	18,51	PEDF	80,84	pigment epithelium-derived factor	PEDF	57104	57104	Gene	Gene	START_ENTITY|dep|characterization characterization|nmod|END_ENTITY	Recombinant human pigment_epithelium-derived_factor -LRB- PEDF -RRB- : characterization of PEDF overexpressed and secreted by eukaryotic cells .
12670505	0	pigment_epithelium-derived_factor	47,80	VEGFR-1	96,103	pigment epithelium-derived factor	VEGFR-1	57104	2321	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Vascular_endothelial_growth_factor upregulates pigment_epithelium-derived_factor expression via VEGFR-1 in human retinal pigment epithelial cells .
12670505	0	pigment_epithelium-derived_factor	47,80	Vascular_endothelial_growth_factor	0,34	pigment epithelium-derived factor	Vascular endothelial growth factor	57104	7422	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor upregulates pigment_epithelium-derived_factor expression via VEGFR-1 in human retinal pigment epithelial cells .
11782462	0	pigment_epithelium-derived_factor	75,108	vascular_endothelial_growth_factor	19,53	pigment epithelium-derived factor	vascular endothelial growth factor	287526(Tax:10116)	83785(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of vascular_endothelial_growth_factor and up-regulation of pigment_epithelium-derived_factor : a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5 .
12779248	0	pigment_epithelium-derived_factor	75,108	vascular_endothelial_growth_factor	17,51	pigment epithelium-derived factor	vascular endothelial growth factor	57104	7422	Gene	Gene	levels|amod|START_ENTITY Up-regulation|nmod|levels Up-regulation|nmod|END_ENTITY	Up-regulation of vascular_endothelial_growth_factor and down-regulation of pigment_epithelium-derived_factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes .
17908464	0	pigment_epithelium-derived_factor	8,41	vascular_endothelial_growth_factor	119,153	pigment epithelium-derived factor	vascular endothelial growth factor	57104	7422	Gene	Gene	Role|nmod|START_ENTITY Role|acl|induced induced|nmod|END_ENTITY	Role of pigment_epithelium-derived_factor on proliferation and migration of choroidal capillary endothelium induced by vascular_endothelial_growth_factor in vitro .
21707863	0	pigment_epithelium-derived_factor	15,48	vascular_endothelial_growth_factor	144,178	pigment epithelium-derived factor	vascular endothelial growth factor	57104	7422	Gene	Gene	Combination|nmod|START_ENTITY enhances|nsubj|Combination enhances|advcl|downregulating downregulating|dobj|expression expression|compound|END_ENTITY	Combination of pigment_epithelium-derived_factor with radiotherapy enhances the antitumor effects on nasopharyngeal_carcinoma by downregulating vascular_endothelial_growth_factor expression and angiogenesis .
25948043	0	pigment_epithelium-derived_factor	12,45	vascular_endothelial_growth_factor	57,91	pigment epithelium-derived factor	vascular endothelial growth factor	57104	7422	Gene	Gene	PEDF|compound|START_ENTITY binds|nsubj|PEDF binds|dobj|END_ENTITY	Recombinant pigment_epithelium-derived_factor PEDF binds vascular_endothelial_growth_factor receptors 1 and 2 .
20141354	0	pigment_epithelium_derived_factor	35,68	PEDF	70,74	pigment epithelium derived factor	PEDF	57104	57104	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Protein_kinase_C_beta -LRB- PRKCB1 -RRB- and pigment_epithelium_derived_factor -LRB- PEDF -RRB- gene polymorphisms and diabetic_retinopathy in a south Indian cohort .
24078214	0	pigment_epithelium_derived_factor	11,44	PEDF	46,50	pigment epithelium derived factor	PEDF	57104	57104	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of pigment_epithelium_derived_factor -LRB- PEDF -RRB- on malignant_peripheral_nerve_sheath_tumours -LRB- MPNSTs -RRB- .
7588268	0	pim-1	19,24	prolactin	39,48	pim-1	prolactin	24649(Tax:10116)	24683(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|nmod|END_ENTITY	Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2_lymphoma cells .
16326834	0	pit-1	12,17	growth_hormone-releasing_hormone_receptor	47,88	pit-1	growth hormone-releasing hormone receptor	25517(Tax:10116)	25321(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	The role of pit-1 in the regulation of the rat growth_hormone-releasing_hormone_receptor gene transcription by glucocorticoids .
1321043	0	pituitary_adenylate-cyclase-activating-peptide	45,91	PACAP	93,98	pituitary adenylate-cyclase-activating-peptide	PACAP	116	116	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Structural requirements for the occupancy of pituitary_adenylate-cyclase-activating-peptide -LRB- PACAP -RRB- receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes .
15721490	0	pituitary_adenylate_cyclase-activating_peptide	8,54	PACAP	56,61	pituitary adenylate cyclase-activating peptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of pituitary_adenylate_cyclase-activating_peptide -LRB- PACAP -RRB- in the cyclic recruitment of immature follicles in the rat ovary .
19346254	0	pituitary_adenylate_cyclase-activating_polypeptide	29,79	Lot1	0,4	pituitary adenylate cyclase-activating polypeptide	Lot1	24166(Tax:10116)	25157(Tax:10116)	Gene	Gene	element|nmod|START_ENTITY element|dep|END_ENTITY	Lot1 is a key element of the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- / cyclic_AMP pathway that negatively regulates neuronal precursor proliferation .
10389149	0	pituitary_adenylate_cyclase-activating_polypeptide	22,72	PACAP	74,79	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Stimulatory effect of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the hypothalamus and cerebral cortex of four avians and rat .
10441752	0	pituitary_adenylate_cyclase-activating_polypeptide	37,87	PACAP	89,94	pituitary adenylate cyclase-activating polypeptide	PACAP	116	116	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization and localization of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- binding sites in the brain of the frog Rana ridibunda .
10909177	0	pituitary_adenylate_cyclase-activating_polypeptide	11,61	PACAP	63,68	pituitary adenylate cyclase-activating polypeptide	PACAP	101800734	101800734	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on cyclic_AMP formation in the duck and goose brain .
12951407	0	pituitary_adenylate_cyclase-activating_polypeptide	63,113	PACAP	115,120	pituitary adenylate cyclase-activating polypeptide	PACAP	116	116	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	Regional concentration and chromatographic characterization of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the brain of the bullfrog , Rana catesbeiana .
1331206	0	pituitary_adenylate_cyclase-activating_polypeptide	60,110	PACAP	112,117	pituitary adenylate cyclase-activating polypeptide	PACAP	116	116	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Immunohistochemical distribution and biological activity of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the central nervous system of the frog Rana ridibunda .
16124881	0	pituitary_adenylate_cyclase-activating_polypeptide	91,141	PACAP	143,148	pituitary adenylate cyclase-activating polypeptide	PACAP	11516(Tax:10090)	11516(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Epidermal_growth_factor -LRB- EGF -RRB- withdrawal masks gene expression differences in the study of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- activation of primary neural stem cell proliferation .
18313848	0	pituitary_adenylate_cyclase-activating_polypeptide	8,58	PACAP	60,65	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the action of ginsenoside_Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes .
19914336	0	pituitary_adenylate_cyclase-activating_polypeptide	33,83	PACAP	85,90	pituitary adenylate cyclase-activating polypeptide	PACAP	116	116	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible association between the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- gene and major_depressive_disorder .
21185294	0	pituitary_adenylate_cyclase-activating_polypeptide	12,62	PACAP	64,69	pituitary adenylate cyclase-activating polypeptide	PACAP	116	116	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the plasma and milk of ruminant animals .
7624029	0	pituitary_adenylate_cyclase-activating_polypeptide	39,89	PACAP	91,96	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Mitogenic and antimitogenic effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in adult rat chromaffin cell cultures .
8102056	0	pituitary_adenylate_cyclase-activating_polypeptide	22,72	PACAP	74,79	pituitary adenylate cyclase-activating polypeptide	PACAP	11516(Tax:10090)	11516(Tax:10090)	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Stimulatory action of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on thyroid gland .
8532586	0	pituitary_adenylate_cyclase-activating_polypeptide	36,86	PACAP	88,93	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the adrenal medulla of the rat .
8714702	0	pituitary_adenylate_cyclase-activating_polypeptide	48,98	PACAP	100,105	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Tissue-specific and developmental expression of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- receptors in rat brain .
8943280	0	pituitary_adenylate_cyclase-activating_polypeptide	44,94	PACAP	96,101	pituitary adenylate cyclase-activating polypeptide	PACAP	116	116	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Molecular cloning of a novel variant of the pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- receptor that stimulates calcium influx by activation of L-type calcium channels .
9191084	0	pituitary_adenylate_cyclase-activating_polypeptide	14,64	PACAP	66,71	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- in the mesencephalic trigeminal nucleus of the rat after transsection of the masseteric nerve .
9282945	0	pituitary_adenylate_cyclase-activating_polypeptide	14,64	PACAP	66,71	pituitary adenylate cyclase-activating polypeptide	PACAP	116	116	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- receptors and PACAP in human fetal retina .
9843161	0	pituitary_adenylate_cyclase-activating_polypeptide	44,94	PACAP	96,101	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neurotrophic and neuroprotective effects of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- on mesencephalic dopaminergic neurons .
9927311	0	pituitary_adenylate_cyclase-activating_polypeptide	28,78	PACAP	80,85	pituitary adenylate cyclase-activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Gonadotropin stimulation of pituitary_adenylate_cyclase-activating_polypeptide -LRB- PACAP -RRB- messenger ribonucleic_acid in the rat ovary and the role of PACAP as a follicle survival factor .
12122016	0	pituitary_adenylate_cyclase-activating_polypeptide	14,64	TTF-1	87,92	pituitary adenylate cyclase-activating polypeptide	TTF-1	24166(Tax:10116)	499766(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of pituitary_adenylate_cyclase-activating_polypeptide gene transcription by TTF-1 , a homeodomain-containing transcription factor .
25066643	0	pituitary_adenylate_cyclase-activating_polypeptide	40,90	VPAC1_receptor	109,123	pituitary adenylate cyclase-activating polypeptide	VPAC1 receptor	116	7433	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Augmented cystine-glutamate exchange by pituitary_adenylate_cyclase-activating_polypeptide signaling via the VPAC1_receptor .
17065411	0	pituitary_adenylate_cyclase-activating_polypeptide	45,95	vasoactive_intestinal_polypeptide	96,129	pituitary adenylate cyclase-activating polypeptide	vasoactive intestinal polypeptide	24166(Tax:10116)	117064(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|dep|receptors receptors|amod|END_ENTITY	Characterization and expression of different pituitary_adenylate_cyclase-activating_polypeptide / vasoactive_intestinal_polypeptide receptors in rat ovarian follicles .
7609919	0	pituitary_adenylate_cyclase-activating_polypeptide	95,145	vasoactive_intestinal_polypeptide	24,57	pituitary adenylate cyclase-activating polypeptide	vasoactive intestinal polypeptide	24166(Tax:10116)	117064(Tax:10116)	Gene	Gene	action|nmod|START_ENTITY stimulating|dobj|action stimulating|nsubj|involvement involvement|nmod|END_ENTITY	Possible involvement of vasoactive_intestinal_polypeptide in the central stimulating action of pituitary_adenylate_cyclase-activating_polypeptide on prolactin secretion in the rat .
17900711	0	pituitary_adenylate_cyclase-activating_polypeptide-specific_receptor	33,101	PAC1R	103,108	pituitary adenylate cyclase-activating polypeptide-specific receptor	PAC1R	117	117	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and localization of pituitary_adenylate_cyclase-activating_polypeptide-specific_receptor -LRB- PAC1R -RRB- in the rostral migratory stream of the infant mouse brain .
8728481	0	pituitary_adenylate_cyclase_activating_peptide	14,60	PACAP	62,67	pituitary adenylate cyclase activating peptide	PACAP	116	116	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of pituitary_adenylate_cyclase_activating_peptide -LRB- PACAP -RRB- on the nociceptive formalin test .
25215080	0	pituitary_adenylate_cyclase_activating_polypeptide	11,61	CD4	65,68	pituitary adenylate cyclase activating polypeptide	CD4	24166(Tax:10116)	24932(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of pituitary_adenylate_cyclase_activating_polypeptide on CD4 -LRB- + -RRB- / CD8 -LRB- + -RRB- T cell levels after traumatic_brain_injury in a rat model .
10219831	0	pituitary_adenylate_cyclase_activating_polypeptide	19,69	PACAP	71,76	pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Central effects of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- on gastric_motility and emptying in rats .
10945291	0	pituitary_adenylate_cyclase_activating_polypeptide	10,60	PACAP	62,67	pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- as a regulator of paracrine interactions between folliculo-stellate cells and gonadotropes through the control of activin-follistatin interactions .
11288374	0	pituitary_adenylate_cyclase_activating_polypeptide	49,99	PACAP	101,106	pituitary adenylate cyclase activating polypeptide	PACAP	116	116	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Structure , localization and physiologic role of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- -RSB- .
14560155	0	pituitary_adenylate_cyclase_activating_polypeptide	7,57	PACAP	59,64	pituitary adenylate cyclase activating polypeptide	PACAP	116	116	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Plasma pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- levels in chronic hepatitis_B patients under lamivudine treatment .
1522745	0	pituitary_adenylate_cyclase_activating_polypeptide	23,73	PACAP	75,80	pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Contrasting effects of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- on in vivo and in vitro prolactin and growth hormone release in male rats .
16888234	0	pituitary_adenylate_cyclase_activating_polypeptide	11,61	PACAP	63,68	pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- in detrusor_hyperreflexia after spinal_cord_injury -LRB- SCI -RRB- .
1730060	0	pituitary_adenylate_cyclase_activating_polypeptide	23,73	PACAP	75,80	pituitary adenylate cyclase activating polypeptide	PACAP	116	116	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure of the human pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- gene .
7724826	0	pituitary_adenylate_cyclase_activating_polypeptide	14,64	PACAP	66,71	pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- gene by rat spermatogenic cells .
8868261	0	pituitary_adenylate_cyclase_activating_polypeptide	24,74	PACAP	76,81	pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Facilitatory effects of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- on neurons in the magnocellular portion of the rat hypothalamic paraventricular nucleus -LRB- PVN -RRB- in vitro .
8951643	0	pituitary_adenylate_cyclase_activating_polypeptide	16,66	PACAP	68,73	pituitary adenylate cyclase activating polypeptide	PACAP	116	24166(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- immunoreactivity in the hypothalamus and extended amygdala of the rat .
9721947	0	pituitary_adenylate_cyclase_activating_polypeptide	14,64	PACAP	66,71	pituitary adenylate cyclase activating polypeptide	PACAP	24166(Tax:10116)	24166(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- in the postnatal and adult rat cerebellar cortex .
11048804	0	pituitary_homeo_box_1	14,35	Ptx1	37,41	pituitary homeo box 1	Ptx1	5307	5307	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pituitary_homeo_box_1 -LRB- Ptx1 -RRB- in human non-neoplastic pituitaries and pituitary_adenomas .
20807761	0	pituitary_transcription_factor_1	132,164	Pit-1	166,171	pituitary transcription factor 1	Pit-1	18736(Tax:10090)	18736(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MicroRNAs regulate pituitary development , and microRNA 26b specifically targets lymphoid_enhancer_factor_1 -LRB- Lef-1 -RRB- , which modulates pituitary_transcription_factor_1 -LRB- Pit-1 -RRB- expression .
12554778	0	pituitary_tumor-transforming_gene	6,39	PTTG1	41,46	pituitary tumor-transforming gene	PTTG1	9232	9232	Gene	Gene	motif|amod|START_ENTITY motif|compound|END_ENTITY	Human pituitary_tumor-transforming_gene -LRB- PTTG1 -RRB- motif suppresses prolactin expression .
23404407	0	pituitary_tumor_transforming_gene	14,47	PTTG	49,53	pituitary tumor transforming gene	PTTG	9232	9232	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pituitary_tumor_transforming_gene -LRB- PTTG -RRB- in human pituitary_macroadenomas .
24176776	0	pituitary_tumor_transforming_gene	18,51	PTTG	53,57	pituitary tumor transforming gene	PTTG	9232	9232	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of pituitary_tumor_transforming_gene -LRB- PTTG -RRB- is associated with tumor progression and poor prognosis in patients with esophageal_squamous_cell_carcinoma .
16378119	0	pituitary_tumor_transforming_gene_1	29,64	PTTG1	66,71	pituitary tumor transforming gene 1	PTTG1	9232	9232	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	-LSB- Regulation of expression of pituitary_tumor_transforming_gene_1 -LRB- PTTG1 -RRB- by androgen in prostate_cancer -RSB- .
16619532	0	pituitary_tumor_transforming_gene_1	16,51	PTTG1	53,58	pituitary tumor transforming gene 1	PTTG1	9232	9232	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of pituitary_tumor_transforming_gene_1 -LRB- PTTG1 -RRB- in prostate_cancer .
12590639	0	pituitary_tumour_transforming_gene	25,59	PTTG	61,65	pituitary tumour transforming gene	PTTG	9232	9232	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The relationship between pituitary_tumour_transforming_gene -LRB- PTTG -RRB- expression and in vitro hormone and vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from human pituitary_adenomas .
12617811	0	piwi	48,52	Ziwi	0,4	piwi	Ziwi	34521(Tax:7227)	368200(Tax:7955)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Ziwi , the zebrafish homologue of the Drosophila piwi : co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults .
14516689	0	piwi	48,52	Ziwi	0,4	piwi	Ziwi	34521(Tax:7227)	368200(Tax:7955)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Ziwi , the zebrafish homologue of the Drosophila piwi : co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults .
17266438	0	pkr	57,60	tlr3	49,53	pkr	tlr3	19106(Tax:10090)	142980(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Enlarged spleens without enlarged lymph nodes in tlr3 - / - pkr - / - mice .
26438258	0	pla	4,7	plasminogen_activator	23,44	pla	plasminogen activator	13917718	15151870	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The pla gene , encoding plasminogen_activator , is not specific to Yersinia_pestis .
6318674	0	placenta-specific_tissue_protein_12	10,45	PP12	47,51	placenta-specific tissue protein 12	PP12	3484	3484	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of placenta-specific_tissue_protein_12 -LRB- PP12 -RRB- in serum during normal pregnancy and in patients with trophoblastic_tumour .
8919031	0	placenta_growth_factor	16,38	PIGF	40,44	placenta growth factor	PIGF	5228	5281	Gene	Gene	Localisation|nmod|START_ENTITY Localisation|appos|END_ENTITY	Localisation of placenta_growth_factor -LRB- PIGF -RRB- in human term placenta .
9778119	0	placenta_growth_factor	8,30	PIGF	32,36	placenta growth factor	PIGF	5228	5281	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of placenta_growth_factor -LRB- PIGF -RRB- in human extravillous_trophoblast proliferation , migration and invasiveness .
15117604	0	placenta_growth_factor	24,46	PlGF	48,52	placenta growth factor	PlGF	5228	5228	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Prospective analysis of placenta_growth_factor -LRB- PlGF -RRB- concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia .
17917370	0	placenta_growth_factor	42,64	PlGF	66,70	placenta growth factor	PlGF	94203(Tax:10116)	94203(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Streptozotocin-induced diabetes decreases placenta_growth_factor -LRB- PlGF -RRB- levels in rat placenta .
8148155	0	placenta_growth_factor	26,48	PlGF-2	50,56	placenta growth factor	PlGF-2	5228	5228	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	A heparin-binding form of placenta_growth_factor -LRB- PlGF-2 -RRB- is expressed in human umbilical vein endothelial cells and in placenta .
15501243	0	placenta_growth_factor	14,36	VEGF	58,62	placenta growth factor	VEGF	5228	7422	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of placenta_growth_factor is regulated by both VEGF and hyperglycaemia via VEGFR-2 .
16164411	0	placenta_growth_factor	42,64	metal_responsive_transcription_factor-1	84,123	placenta growth factor	metal responsive transcription factor-1	5228	4520	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	NF-kappaB contributes to transcription of placenta_growth_factor and interacts with metal_responsive_transcription_factor-1 in hypoxic human cells .
23042533	0	placenta_growth_factor	15,37	oncostatin_M	52,64	placenta growth factor	oncostatin M	5228	5008	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Enhancement of placenta_growth_factor expression by oncostatin_M in human rheumatoid_arthritis synovial fibroblasts .
9049616	0	placental_alkaline_phosphatase	16,46	PLAP	48,52	placental alkaline phosphatase	PLAP	250	250	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Distribution of placental_alkaline_phosphatase -LRB- PLAP -RRB- gene frequencies in Andhra Pradesh -LRB- south India -RRB- .
9387432	0	placental_alkaline_phosphatase	18,48	PLAP	50,54	placental alkaline phosphatase	PLAP	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of placental_alkaline_phosphatase -LRB- PLAP -RRB- for detecting the damages of alveolar type I cells caused by smoke_inhalation -RSB- .
7802069	0	placental_anticoagulant_protein-I	24,57	annexin-V	13,22	placental anticoagulant protein-I	annexin-V	308	308	Gene	Gene	Reduction|appos|START_ENTITY Reduction|nmod|END_ENTITY	Reduction of annexin-V -LRB- placental_anticoagulant_protein-I -RRB- on placental villi of women with antiphospholipid antibodies and recurrent spontaneous_abortion .
2144635	0	placental_anticoagulant_protein-I	15,48	lipocortin_V	50,62	placental anticoagulant protein-I	lipocortin V	308	308	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of placental_anticoagulant_protein-I -LRB- lipocortin_V -RRB- with model membranes .
10695988	0	placental_bikunin	76,93	hepatocyte_growth_factor_activator_inhibitor_type-2	24,75	placental bikunin	hepatocyte growth factor activator inhibitor type-2	10653	10653	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Conserved expression of hepatocyte_growth_factor_activator_inhibitor_type-2 / placental_bikunin in human colorectal_carcinomas .
20500895	0	placental_growth_factor	45,68	Angiotensin_II	0,14	placental growth factor	Angiotensin II	5228	183	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Angiotensin_II upregulates the expression of placental_growth_factor in human vascular endothelial cells and smooth muscle cells .
13678785	0	placental_growth_factor	37,60	Bone_morphogenetic_protein_2	0,28	placental growth factor	Bone morphogenetic protein 2	5228	650	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Bone_morphogenetic_protein_2 induces placental_growth_factor in mesenchymal stem cells .
15938782	0	placental_growth_factor	39,62	Fas_antigen	15,26	placental growth factor	Fas antigen	5228	355	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of Fas_antigen and ligand , placental_growth_factor in placenta of pregnant women with pre-eclampsia -RSB- .
18160678	0	placental_growth_factor	31,54	PGF	56,59	placental growth factor	PGF	5228	5228	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Glial_cell_missing_1 regulates placental_growth_factor -LRB- PGF -RRB- gene transcription in human trophoblast .
26105949	0	placental_growth_factor	17,40	PlGF	42,46	placental growth factor	PlGF	5228	5228	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Determination of placental_growth_factor -LRB- PlGF -RRB- levels in healthy pregnant women without signs or symptoms of preeclampsia .
12783695	0	placental_growth_factor	49,72	interleukin-6	32,45	placental growth factor	interleukin-6	5228	3569	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Study on regulatory effects of interleukin-6 on placental_growth_factor expression in trophoblast cells -RSB- .
23452854	0	placental_growth_factor	10,33	neuropilin_1	34,46	placental growth factor	neuropilin 1	5228	8829	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	Targeting placental_growth_factor / neuropilin_1 pathway inhibits growth and spread of medulloblastoma .
14684734	0	placental_growth_factor	25,48	vascular_endothelial_growth_factor	77,111	placental growth factor	vascular endothelial growth factor	5228	7422	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|receptor-1 receptor-1|compound|END_ENTITY	The crystal structure of placental_growth_factor in complex with domain 2 of vascular_endothelial_growth_factor receptor-1 .
15710418	0	placental_growth_factor	16,39	vascular_endothelial_growth_factor	43,77	placental growth factor	vascular endothelial growth factor	18654(Tax:10090)	22339(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of placental_growth_factor by vascular_endothelial_growth_factor via a post-transcriptional mechanism .
20145150	0	placental_growth_factor	2,25	vascular_endothelial_growth_factor	54,88	placental growth factor	vascular endothelial growth factor	5228	7422	Gene	Gene	variant|compound|START_ENTITY variant|amod|unable unable|xcomp|recognize recognize|xcomp|receptor-1 receptor-1|nsubj|END_ENTITY	A placental_growth_factor variant unable to recognize vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization .
21513467	0	placental_growth_factor	6,29	vascular_endothelial_growth_factor	75,109	placental growth factor	vascular endothelial growth factor	5228	7422	Gene	Gene	START_ENTITY|appos|vascular_endothelial_growth_factor vascular_endothelial_growth_factor|appos|END_ENTITY	Serum placental_growth_factor , vascular_endothelial_growth_factor , soluble vascular_endothelial_growth_factor receptor-1 and -2 levels in periodontal_disease , and adverse pregnancy outcomes .
22433027	0	placental_growth_factor	24,47	vascular_endothelial_growth_factor	49,83	placental growth factor	vascular endothelial growth factor	5228	7422	Gene	Gene	kinase|compound|START_ENTITY kinase|dep|END_ENTITY	Accuracy of circulating placental_growth_factor , vascular_endothelial_growth_factor , soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia : a systematic review and meta-analysis .
10715552	0	placental_lactogen	36,54	Activator_protein-2	0,19	placental lactogen	Activator protein-2	1443	7020	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Activator_protein-2 regulates human placental_lactogen gene expression .
7957644	0	placental_lactogen	29,47	Angiotensin_II	0,14	placental lactogen	Angiotensin II	1443	183	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces human placental_lactogen and pregnancy-specific_beta_1-glycoprotein secretion via an angiotensin AT1 receptor .
7588308	0	placental_lactogen	30,48	Apolipoprotein_A-I	0,18	placental lactogen	Apolipoprotein A-I	1443	335	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Apolipoprotein_A-I stimulates placental_lactogen expression by human trophoblast cells .
9806357	0	placental_lactogen	36,54	Apolipoprotein_A-I	0,18	placental lactogen	Apolipoprotein A-I	1443	335	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Apolipoprotein_A-I stimulates human placental_lactogen release by activation of MAP kinase .
11985517	0	placental_lactogen	17,35	CD163	57,62	placental lactogen	CD163	1443	9332	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	Effects of human placental_lactogen on the expression of CD163 and CD14 on human monocytes in culture .
24408518	0	placental_lactogen	6,24	CYP2E1	33,39	placental lactogen	CYP2E1	1443	1571	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Human placental_lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes .
2543179	0	placental_lactogen	46,64	GHRH	7,11	placental lactogen	GHRH	1443	2691	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|appos|concentrations	Plasma GHRH , CRH , ACTH , beta-endorphin , human placental_lactogen , GH and cortisol concentrations at the third trimester of pregnancy .
1125152	0	placental_lactogen	30,48	HPL	50,53	placental lactogen	HPL	1443	3956	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	The prognostic value of human placental_lactogen -LRB- HPL -RRB- levels in threatened abortion .
187001	0	placental_lactogen	12,30	HPL	32,35	placental lactogen	HPL	1443	3956	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum human placental_lactogen -LRB- HPL -RRB- levels in patients with intact hydatidiform mole .
3902860	0	placental_lactogen	96,114	HPL	144,147	placental lactogen	HPL	1443	3956	Gene	Gene	START_ENTITY|dep|mediation mediation|nmod|action action|compound|END_ENTITY	Incorporation of -LSB- 3H -RSB- thymidine by isolated fetal myoblasts and fibroblasts in response to human placental_lactogen -LRB- HPL -RRB- : possible mediation of HPL action by release of immunoreactive SM-C .
4339409	0	placental_lactogen	32,50	HPL	52,55	placental lactogen	HPL	1443	3956	Gene	Gene	properties|nmod|START_ENTITY properties|appos|END_ENTITY	-LSB- Biological properties of human placental_lactogen -LRB- HPL ; human chorionic somatomammotropin -RRB- -RSB- .
4985807	2	placental_lactogen	72,90	HPL	92,95	placental lactogen	HPL	1443	3956	Gene	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|appos|END_ENTITY	Biosynthesis of human placental_lactogen -LRB- HPL -RRB- -RSB- .
7008399	0	placental_lactogen	7,25	HPL	27,30	placental lactogen	HPL	1443	3956	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Human placental_lactogen -LRB- HPL -RRB- levels in the maternal serum following long-term intake of xantinol_nicotinate -LRB- Complamin_Retard -RRB- -LRB- author 's transl -RRB- -RSB- .
7008458	0	placental_lactogen	20,38	HPL	40,43	placental lactogen	HPL	1443	3956	Gene	Gene	Behaviour|nmod|START_ENTITY Behaviour|appos|END_ENTITY	-LSB- Behaviour of human placental_lactogen -LRB- HPL -RRB- following continuous glucose infusion in late pregnancy -LRB- author 's transl -RRB- -RSB- .
7304144	0	placental_lactogen	26,44	HPL	46,49	placental lactogen	HPL	1443	3956	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of human placental_lactogen -LRB- HPL -RRB- in an unselected obstetrical population .
8033820	0	placental_lactogen	25,43	Interleukin-6	0,13	placental lactogen	Interleukin-6	1443	3569	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates placental_lactogen expression by human trophoblast cells .
10534168	0	placental_lactogen	61,79	growth_hormone	46,60	placental lactogen	growth hormone	1443	2688	Gene	Gene	pattern|dep|START_ENTITY pattern|nmod|END_ENTITY	The testis-specific expression pattern of the growth_hormone / placental_lactogen -LRB- GH/PL -RRB- gene cluster changes with malignancy .
8894644	0	placental_lactogen	39,57	growth_hormone	62,76	placental lactogen	growth hormone	443319(Tax:9940)	443329(Tax:9940)	Gene	Gene	_|compound|START_ENTITY _|compound|administration administration|amod|END_ENTITY	Differential effects of maternal ovine placental_lactogen and growth_hormone -LRB- GH -RRB- administration on GH_receptor , insulin-like_growth_factor _ -LRB- IGF -RRB- -1 and IGF binding protein-3 gene expression in the pregnant and fetal sheep .
9329365	0	placental_lactogen	25,43	growth_hormone	10,24	placental lactogen	growth hormone	1443	2688	Gene	Gene	transcription|compound|START_ENTITY transcription|dep|END_ENTITY	Selective growth_hormone / placental_lactogen gene transcription and hormone production in pre - and postmenopausal human ovaries .
9428574	0	placental_lactogen	20,38	growth_hormone	51,65	placental lactogen	growth hormone	1443	2688	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of human placental_lactogen and variant growth_hormone genes in placentas .
3554836	0	placental_lactogen	38,56	hPL	58,61	placental lactogen	hPL	1443	3956	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- A pregnancy without detectable human placental_lactogen -LRB- hPL -RRB- -RSB- .
3767004	0	placental_lactogen	61,79	hPL	81,84	placental lactogen	hPL	1443	3956	Gene	Gene	secretion|nmod|START_ENTITY observations|nmod|secretion observations|appos|END_ENTITY	Immunoelectron microscope observations on secretion of human placental_lactogen -LRB- hPL -RRB- in the human chorionic villi .
6851204	0	placental_lactogen	32,50	hPL	52,55	placental lactogen	hPL	1443	3956	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	-LSB- Clinical significance of human placental_lactogen -LRB- hPL -RRB- -RSB- .
7084559	0	placental_lactogen	37,55	hPL	57,60	placental lactogen	hPL	1443	3956	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	The synthesis and secretion of human placental_lactogen -LRB- hPL -RRB- in cultured term placenta .
10854711	0	placental_lactogen-1	55,75	PKC_delta	14,23	placental lactogen-1	PKC delta	53950(Tax:10116)	5580	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of PKC_delta expression by estrogen and rat placental_lactogen-1 in luteinized rat ovarian granulosa cells .
7492690	0	placental_lactogen-II	40,61	transforming_growth_factor_beta_1	75,108	placental lactogen-II	transforming growth factor beta 1	18776(Tax:10090)	21803(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Posttranscriptional inhibition of mouse placental_lactogen-II secretion by transforming_growth_factor_beta_1 : synergistic effects with epidermal_growth_factor and interleukin-6 .
1454826	0	placental_lactogen_I	41,61	Epidermal_growth_factor	0,23	placental lactogen I	Epidermal growth factor	18775(Tax:10090)	13645(Tax:10090)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates mouse placental_lactogen_I but inhibits mouse placental_lactogen_II secretion in vitro .
16794002	0	placental_lactogen_II	47,68	AP2_gamma	28,37	placental lactogen II	AP2 gamma	24283(Tax:10116)	362280(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|identification identification|nmod|END_ENTITY	Proteomic identification of AP2_gamma as a rat placental_lactogen_II trophoblast cell-specific enhancer binding protein .
8265646	0	placental_lactogen_II	29,50	Interleukin_6	0,13	placental lactogen II	Interleukin 6	18776(Tax:10090)	16193(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin_6 inhibits mouse placental_lactogen_II but not mouse placental_lactogen_I secretion in vitro .
3595528	0	placental_lactogen_II	31,52	growth_hormone	81,95	placental lactogen II	growth hormone	18776(Tax:10090)	14599(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	The lipolytic effects of mouse placental_lactogen_II , mouse prolactin , and mouse growth_hormone on adipose tissue from virgin and pregnant mice .
2343034	0	placental_lactogen_II	29,50	prolactin-like_proteins_A_and_B	59,90	placental lactogen II	prolactin-like proteins A and B	24283(Tax:10116)	24656;24657	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Cellular localization of rat placental_lactogen_II and rat prolactin-like_proteins_A_and_B by in situ hybridization .
12569180	0	placental_leucine_aminopeptidase	29,61	Interleukin-1beta	0,17	placental leucine aminopeptidase	Interleukin-1beta	4012	3553	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Interleukin-1beta stimulates placental_leucine_aminopeptidase / oxytocinase expression in BeWo choriocarcinoma cells .
16187279	0	placental_leucine_aminopeptidase	17,49	P-LAP	51,56	placental leucine aminopeptidase	P-LAP	4012	4012	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for placental_leucine_aminopeptidase -LRB- P-LAP -RRB- as a determinant of chemoresistance in endometrial_carcinoma cells .
6343531	0	placental_leucine_aminopeptidase	58,90	P-LAP	92,97	placental leucine aminopeptidase	P-LAP	4012	4012	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Changes in plasma renin activity -LRB- PRA -RRB- , angiotensin_I and placental_leucine_aminopeptidase -LRB- P-LAP -RRB- activity during normal pregnancy .
8926015	0	placental_leucine_aminopeptidase	51,83	P-LAP	85,90	placental leucine aminopeptidase	P-LAP	4012	4012	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Relationship between the changes in maternal serum placental_leucine_aminopeptidase -LRB- P-LAP -RRB- activity and umbilical artery waveforms in normal pregnancy .
12684429	0	placental_leucine_aminopeptidase	17,49	oxytocin	85,93	placental leucine aminopeptidase	oxytocin	4012	5020	Gene	Gene	role|nmod|START_ENTITY role|nmod|effect effect|nmod|END_ENTITY	Possible role of placental_leucine_aminopeptidase in the antiproliferative effect of oxytocin in human endometrial_adenocarcinoma .
11389728	0	placental_leucine_aminopeptidase	14,46	oxytocinase	47,58	placental leucine aminopeptidase	oxytocinase	171105(Tax:10116)	171105(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of placental_leucine_aminopeptidase / oxytocinase in neuronal cells and its action on neuronal peptides .
11481040	0	placental_leucine_aminopeptidase	108,140	oxytocinase	141,152	placental leucine aminopeptidase	oxytocinase	4012	4012	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Genomic organization of the human adipocyte-derived_leucine_aminopeptidase gene and its relationship to the placental_leucine_aminopeptidase / oxytocinase gene .
12569180	0	placental_leucine_aminopeptidase	29,61	oxytocinase	62,73	placental leucine aminopeptidase	oxytocinase	4012	4012	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Interleukin-1beta stimulates placental_leucine_aminopeptidase / oxytocinase expression in BeWo choriocarcinoma cells .
1731608	0	placental_leucine_aminopeptidase	24,56	oxytocinase	60,71	placental leucine aminopeptidase	oxytocinase	4012	4012	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human placental_leucine_aminopeptidase as oxytocinase .
9733056	0	placental_leucine_aminopeptidase	36,68	oxytocinase	69,80	placental leucine aminopeptidase	oxytocinase	4012	4012	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Immunohistochemical localization of placental_leucine_aminopeptidase / oxytocinase in normal human placental , fetal and adult tissues .
2016092	0	placental_protein_14	10,30	PP14	32,36	placental protein 14	PP14	5047	5047	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human placental_protein_14 -LRB- PP14 -RRB- gene is localized on chromosome 9q34 .
2307483	0	placental_protein_14	20,40	PP14	42,46	placental protein 14	PP14	5047	5047	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of human placental_protein_14 -LRB- PP14 -RRB- on the production of interleukin-1 from mitogenically stimulated mononuclear cell cultures .
3991471	0	placental_protein_14	20,40	PP14	42,46	placental protein 14	PP14	5047	5047	Gene	Gene	relationship|nmod|START_ENTITY relationship|appos|END_ENTITY	The relationship of placental_protein_14 -LRB- PP14 -RRB- in the mother and fetus to specific products of the human placenta .
8844133	0	placental_protein_14	6,26	PP14	28,32	placental protein 14	PP14	5047	5047	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum placental_protein_14 -LRB- PP14 -RRB- levels in patients with threatened abortion .
6601264	0	placental_protein_5	14,33	PP5	35,38	placental protein 5	PP5	7980	7980	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of placental_protein_5 -LRB- PP5 -RRB- by non-malignant human fibroblasts in culture .
22119253	0	plakophilin-2	17,30	plakophilin-3	54,67	plakophilin-2	plakophilin-3	5318	11187	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder_cancer .
22119253	0	plakophilin-3	54,67	plakophilin-2	17,30	plakophilin-3	plakophilin-2	11187	5318	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder_cancer .
25501895	0	plakophilin_3	43,56	c-Src	0,5	plakophilin 3	c-Src	11187	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	c-Src mediated tyrosine phosphorylation of plakophilin_3 as a new mechanism to control desmosome composition in cells exposed to oxidative stress .
17122425	0	plasma_glutathione_peroxidase	30,59	GPx-3	61,66	plasma glutathione peroxidase	GPx-3	2878	2878	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter polymorphisms in the plasma_glutathione_peroxidase -LRB- GPx-3 -RRB- gene : a novel risk factor for arterial_ischemic_stroke among young adults and children .
18096833	0	plasma_glutathione_peroxidase	38,67	GPx-3	69,74	plasma glutathione peroxidase	GPx-3	2878	2878	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of promoter polymorphisms in the plasma_glutathione_peroxidase -LRB- GPx-3 -RRB- gene as a risk factor for cerebral_venous_thrombosis .
9443814	0	plasma_hyaluronan-binding_protein	38,71	HABP2	85,90	plasma hyaluronan-binding protein	HABP2	3026	3026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the plasma_hyaluronan-binding_protein -LRB- PHBP -RRB- gene -LRB- HABP2 -RRB- .
9443814	0	plasma_hyaluronan-binding_protein	38,71	PHBP	73,77	plasma hyaluronan-binding protein	PHBP	3026	3026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the plasma_hyaluronan-binding_protein -LRB- PHBP -RRB- gene -LRB- HABP2 -RRB- .
11379758	0	plasma_hyaluronan_binding_protein	75,108	serine_protease	47,62	plasma hyaluronan binding protein	serine protease	3026	2147	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|activity activity|amod|END_ENTITY	Proteolytic activation and inactivation of the serine_protease activity of plasma_hyaluronan_binding_protein .
12176993	0	plasma_lysophospholipase_D	24,50	autotaxin	97,106	plasma lysophospholipase D	autotaxin	5168	5168	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of human plasma_lysophospholipase_D , a lysophosphatidic_acid-producing enzyme , as autotaxin , a multifunctional phosphodiesterase .
14555210	0	plasma_membrane_calcium_ATPase	56,86	Basic_fibroblast_growth_factor	0,30	plasma membrane calcium ATPase	Basic fibroblast growth factor	491	2247	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Basic_fibroblast_growth_factor -LRB- bFGF -RRB- regulation of the plasma_membrane_calcium_ATPase -LRB- PMCA -RRB- as part of an anti-apoptotic mechanism of action .
14555210	0	plasma_membrane_calcium_ATPase	56,86	PMCA	88,92	plasma membrane calcium ATPase	PMCA	491	491	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Basic_fibroblast_growth_factor -LRB- bFGF -RRB- regulation of the plasma_membrane_calcium_ATPase -LRB- PMCA -RRB- as part of an anti-apoptotic mechanism of action .
14555210	0	plasma_membrane_calcium_ATPase	56,86	bFGF	32,36	plasma membrane calcium ATPase	bFGF	491	2247	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Basic_fibroblast_growth_factor -LRB- bFGF -RRB- regulation of the plasma_membrane_calcium_ATPase -LRB- PMCA -RRB- as part of an anti-apoptotic mechanism of action .
25802735	0	plasma_membrane_monoamine_transporter	91,128	PMAT	130,134	plasma membrane monoamine transporter	PMAT	222962	222962	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Autism_spectrum_disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma_membrane_monoamine_transporter -LRB- PMAT -RRB- gene .
25802735	0	plasma_membrane_monoamine_transporter	91,128	SLC29A4	83,90	plasma membrane monoamine transporter	SLC29A4	222962	222962	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Autism_spectrum_disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma_membrane_monoamine_transporter -LRB- PMAT -RRB- gene .
20012264	0	plasma_membrane_monoamine_transporter	25,62	hPMAT	64,69	plasma membrane monoamine transporter	hPMAT	222962	222962	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the human plasma_membrane_monoamine_transporter -LRB- hPMAT -RRB- with antidepressants and antipsychotics .
25710294	0	plasma_phospholipid_protein	18,45	PLTP	47,51	plasma phospholipid protein	PLTP	5360	5360	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Elevated baseline plasma_phospholipid_protein -LRB- PLTP -RRB- levels are an independent predictor of long-term all-cause mortality in patients with diabetes_mellitus and known or suspected coronary_artery_disease .
23063469	0	plasmalemma_vesicle-associated_protein	12,50	PLVAP	52,57	plasmalemma vesicle-associated protein	PLVAP	84094(Tax:10090)	84094(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of plasmalemma_vesicle-associated_protein -LRB- PLVAP -RRB- in endothelial cells of Schlemm 's canal and ocular capillaries .
8142660	0	plasmin	83,90	5-lipoxygenase	56,70	plasmin	5-lipoxygenase	5340	240	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Contact activation triggers stimulation of the monocyte 5-lipoxygenase pathway via plasmin .
20553378	0	plasmin	28,35	ADAMTS13	16,24	plasmin	ADAMTS13	5340	11093	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic_thrombocytopenic_purpura .
2958955	0	plasmin	85,92	Fibrinogen	0,10	plasmin	Fibrinogen	5340	2244	Gene	Gene	degradation|compound|START_ENTITY calcium|nmod|degradation effect|nmod|calcium absence|nmod|effect variant|nmod|absence Haifa|dep|variant Haifa|compound|END_ENTITY	Fibrinogen Haifa : fibrinogen variant with absence of protective effect of calcium on plasmin degradation of gamma chains .
9184396	0	plasmin	92,99	Fibrinogen	0,10	plasmin	Fibrinogen	5340	2244	Gene	Gene	involved|nsubjpass|START_ENTITY evidence|dep|involved I|dep|evidence I|amod|END_ENTITY	Fibrinogen heterogeneity in homozygous plasminogen_deficiency type I : further evidence that plasmin is not involved in formation of LMW - and LMW ' - fibrinogen .
16598647	0	plasmin	42,49	Matrix_metalloproteinase-1	0,26	plasmin	Matrix metalloproteinase-1	5340	4312	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Matrix_metalloproteinase-1 activation via plasmin generated on alveolar epithelial cell surfaces .
23024298	0	plasmin	8,15	TRPV5	25,30	plasmin	TRPV5	5340	56302	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Urinary plasmin inhibits TRPV5 in nephrotic-range proteinuria .
1689102	0	plasmin	13,20	Thrombin	0,8	plasmin	Thrombin	5340	2147	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	Thrombin vs. plasmin generation in disseminated_intravascular_coagulation associated with various underlying disorders .
15870504	0	plasmin	48,55	Transforming_growth_factor-beta	0,31	plasmin	Transforming growth factor-beta	5340	7040	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Transforming_growth_factor-beta is activated by plasmin and inhibits smooth muscle cell death in human saphenous vein .
9667615	0	plasmin	70,77	Vitronectin	0,11	plasmin	Vitronectin	5340	7448	Gene	Gene	generation|compound|START_ENTITY inhibition|nmod|generation expression|dep|inhibition expression|compound|END_ENTITY	Vitronectin expression in rheumatoid arthritic synovia -- inhibition of plasmin generation by vitronectin produced in vitro .
4166088	0	plasmin	63,70	alpha-2-macroglobulin	14,35	plasmin	alpha-2-macroglobulin	5340	2	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of alpha-2-macroglobulin in human serum on trypsin , plasmin , and thrombin activities .
4166401	0	plasmin	14,21	alpha-2-macroglobulin	34,55	plasmin	alpha-2-macroglobulin	5340	2	Gene	Gene	activity|compound|START_ENTITY Inhibition|nmod|activity Inhibition|nmod|END_ENTITY	Inhibition of plasmin activity by alpha-2-macroglobulin .
7545523	0	plasmin	18,25	alpha-2-macroglobulin	41,62	plasmin	alpha-2-macroglobulin	5340	2	Gene	Gene	complexes|compound|START_ENTITY Concentration|nmod|complexes Concentration|acl|END_ENTITY	-LSB- Concentration of plasmin complexes with alpha-2-macroglobulin and alpha-2-antiplasmin in blood plasma and serum -RSB- .
1700488	0	plasmin	14,21	alpha_2-macroglobulin	94,115	plasmin	alpha 2-macroglobulin	5340	2	Gene	Gene	miniplasmin|compound|START_ENTITY Regulation|nmod|miniplasmin Regulation|nmod|END_ENTITY	Regulation of plasmin , miniplasmin , and streptokinase-plasmin complex by alpha_2-antiplasmin , alpha_2-macroglobulin , and antithrombin_III in the presence of heparin .
1708234	0	plasmin	52,59	alpha_2-macroglobulin	65,86	plasmin	alpha 2-macroglobulin	5340	2	Gene	Gene	reaction|nmod|START_ENTITY inhibit|dobj|reaction inhibit|advcl|END_ENTITY	Soluble fibrin preparations inhibit the reaction of plasmin with alpha_2-macroglobulin .
2441753	0	plasmin	68,75	alpha_2-macroglobulin	81,102	plasmin	alpha 2-macroglobulin	5340	2	Gene	Gene	modes|nmod|START_ENTITY modes|nmod|END_ENTITY	Some consequences of the covalent and non-covalent binding modes of plasmin with alpha_2-macroglobulin .
4228070	0	plasmin	20,27	alpha_2-macroglobulin	45,66	plasmin	alpha 2-macroglobulin	5340	2	Gene	Gene	Competition|nmod|START_ENTITY Competition|nmod|END_ENTITY	Competition between plasmin and thrombin for alpha_2-macroglobulin .
6196052	0	plasmin	60,67	alpha_2-macroglobulin	18,39	plasmin	alpha 2-macroglobulin	5340	2	Gene	Gene	Reaction|nmod|START_ENTITY Reaction|nmod|half-molecules half-molecules|amod|END_ENTITY	Reaction of human alpha_2-macroglobulin half-molecules with plasmin as a probe of protease binding site structure .
6197993	0	plasmin	21,28	alpha_2-macroglobulin	40,61	plasmin	alpha 2-macroglobulin	5340	2	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human plasmin with human alpha_2-macroglobulin .
1833569	0	plasmin	101,108	alpha_2_plasmin_inhibitor	109,134	plasmin	alpha 2 plasmin inhibitor	5340	5345	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	-LSB- Plasma levels of antithrombin III , thrombin-antithrombin III complex , alpha_2_plasmin_inhibitor and plasmin alpha_2_plasmin_inhibitor complex in normal and sick newborn infants -RSB- .
4339394	0	plasmin	33,40	angiotensin_II	15,29	plasmin	angiotensin II	5340	183	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of angiotensin_II by plasmin .
7512520	0	plasmin	49,56	aprotinin	20,29	plasmin	aprotinin	280897(Tax:9913)	404172(Tax:9913)	Gene	Gene	antibody|compound|START_ENTITY antibody|compound|END_ENTITY	Plasmin modulators , aprotinin and anti-catalytic plasmin antibody , efficiently inhibit destruction of bovine vascular endothelial cells by choriocarcinoma cells .
17991725	0	plasmin	145,152	catestatin	124,134	plasmin	catestatin	5340	1113	Gene	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	Proteolytic cleavage of human chromogranin_a containing naturally occurring catestatin variants : differential processing at catestatin region by plasmin .
12297497	0	plasmin	48,55	chromogranin_A	12,26	plasmin	chromogranin A	5340	1113	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Cleavage of chromogranin_A N-terminal domain by plasmin provides a new mechanism for regulating cell adhesion .
126232	0	plasmin	61,68	fibrinogen	36,46	plasmin	fibrinogen	5340	2244	Gene	Gene	re-examination|nmod|START_ENTITY re-examination|nmod|cleavage cleavage|nmod|END_ENTITY	A re-examination of the cleavage of fibrinogen and fibrin by plasmin .
1387746	0	plasmin	55,62	fibrinogen	41,51	plasmin	fibrinogen	5340	2244	Gene	Gene	-RSB-|compound|START_ENTITY -LSB-|nmod|-RSB- -LSB-|dobj|effect effect|nmod|arginine arginine|nmod|hydrolysis hydrolysis|nmod|END_ENTITY	-LSB- The effect of arginine on hydrolysis of fibrinogen by plasmin and mini-plasmin -RSB- .
148116	0	plasmin	29,36	fibrinogen	66,76	plasmin	fibrinogen	5340	2244	Gene	Gene	product|compound|START_ENTITY Radioimmunoassay|nmod|product Radioimmunoassay|nmod|END_ENTITY	Radioimmunoassay of an early plasmin degradation product of human fibrinogen , `` fragment A '' , and its clinical application .
149393	0	plasmin	59,66	fibrinogen	108,118	plasmin	fibrinogen	5340	2244	Gene	Gene	products|nmod|START_ENTITY characterization|nmod|products protease|nsubj|characterization protease|dobj|cleavage cleavage|nmod|END_ENTITY	Comparative immunochemical characterization of products of plasmin and leukocyte protease cleavage of human fibrinogen .
1531588	0	plasmin	111,118	fibrinogen	97,107	plasmin	fibrinogen	5340	2244	Gene	Gene	differing|nmod|START_ENTITY differing|nmod|digestion digestion|nmod|END_ENTITY	Generation of forms of fragment E with differing thrombin-binding properties during digestion of fibrinogen by plasmin .
16029886	0	plasmin	79,86	fibrinogen	30,40	plasmin	fibrinogen	5340	2244	Gene	Gene	generation|compound|START_ENTITY effect|nmod|generation processing|dep|effect processing|nmod|surfaces surfaces|amod|END_ENTITY	Electrochemical processing of fibrinogen modified-graphite surfaces : effect on plasmin generation from adsorbed plasminogen .
19809304	0	plasmin	12,19	fibrinogen	56,66	plasmin	fibrinogen	5340	2244	Gene	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Analysis of plasmin generation and clot lysis of plasma fibrinogen purified from a heterozygous dysfibrinogenemia , BbetaGly15Cys -LRB- Hamamatsu II -RRB- .
2143650	0	plasmin	14,21	fibrinogen	25,35	plasmin	fibrinogen	5340	2244	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of plasmin by fibrinogen .
2151408	0	plasmin	34,41	fibrinogen	45,55	plasmin	fibrinogen	5340	2244	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of soluble and immobilized plasmin on fibrinogen and platelets .
2478231	0	plasmin	82,89	fibrinogen	58,68	plasmin	fibrinogen	5340	2244	Gene	Gene	epitope|amod|START_ENTITY constitute|dobj|epitope constitute|nsubj|sequences sequences|nmod|chain chain|nmod|END_ENTITY	The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin .
2935535	0	plasmin	56,63	fibrinogen	24,34	plasmin	fibrinogen	5340	2244	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of adsorbed fibrinogen by surface-generated plasmin .
2938303	0	plasmin	63,70	fibrinogen	27,37	plasmin	fibrinogen	5340	2244	Gene	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|nsubj|characteristics characteristics|nmod|END_ENTITY	Kinetic characteristics of fibrinogen and fibrin hydrolysis by plasmin 1 and 2 and miniplasmin .
2958955	0	plasmin	85,92	fibrinogen	18,28	plasmin	fibrinogen	5340	2244	Gene	Gene	degradation|compound|START_ENTITY calcium|nmod|degradation effect|nmod|calcium absence|nmod|effect variant|nmod|absence variant|compound|END_ENTITY	Fibrinogen Haifa : fibrinogen variant with absence of protective effect of calcium on plasmin degradation of gamma chains .
4222714	0	plasmin	64,71	fibrinogen	38,48	plasmin	fibrinogen	5340	2244	Gene	Gene	-RSB-|compound|START_ENTITY proteolysis|nmod|-RSB- proteolysis|nsubj|products products|acl|forming forming|nmod|END_ENTITY	-LSB- Thermostable products forming during fibrinogen proteolysis by plasmin -RSB- .
4222954	0	plasmin	93,100	fibrinogen	66,76	plasmin	fibrinogen	5340	2244	Gene	Gene	use|nmod|START_ENTITY END_ENTITY|nmod|use	-LSB- Fractionation and properties of early products of proteolysis of fibrinogen with the use of plasmin -RSB- .
4229209	0	plasmin	62,69	fibrinogen	18,28	plasmin	fibrinogen	5340	2244	Gene	Gene	interaction|nmod|START_ENTITY Split|nmod|interaction Split|dobj|products products|nmod|END_ENTITY	Split products of fibrinogen after prolonged interaction with plasmin .
47328	0	plasmin	110,117	fibrinogen	72,82	plasmin	fibrinogen	5340	2244	Gene	Gene	cleavage|compound|START_ENTITY associated|nmod|cleavage associated|nsubj|modulation modulation|nmod|regions regions|nmod|END_ENTITY	Conformational and structural modulation of the NH2-terminal regions of fibrinogen and fibrin associated with plasmin cleavage .
6216917	0	plasmin	103,110	fibrinogen	91,101	plasmin	fibrinogen	5340	2244	Gene	Gene	fragments|compound|START_ENTITY END_ENTITY|dep|fragments	Anticoagulant and calcium-binding properties of high molecular weight derivatives of human fibrinogen -LRB- plasmin fragments Y -RRB- .
6219709	0	plasmin	46,53	fibrinogen	81,91	plasmin	fibrinogen	5340	2244	Gene	Gene	role|nmod|START_ENTITY role|nmod|hydrolysis hydrolysis|nmod|END_ENTITY	The role of the lysine binding sites of human plasmin in the hydrolysis of human fibrinogen .
6223426	0	plasmin	65,72	fibrinogen	27,37	plasmin	fibrinogen	5340	2244	Gene	Gene	-RSB-|compound|START_ENTITY hydrolysis|nmod|-RSB- hydrolysis|nsubj|evaluation evaluation|nmod|END_ENTITY	-LSB- Comparative evaluation of fibrinogen and fibrin hydrolysis with plasmin -RSB- .
6240993	0	plasmin	42,49	fibrinogen	55,65	plasmin	fibrinogen	5340	2244	Gene	Gene	START_ENTITY|nmod|E E|compound|END_ENTITY	-LSB- Interaction of heavy and light chains of plasmin with fibrinogen E and D fragments -RSB- .
6453618	0	plasmin	115,122	fibrinogen	91,101	plasmin	fibrinogen	5340	2244	Gene	Gene	produced|nmod|START_ENTITY produced|nsubj|properties properties|nmod|derivatives derivatives|nmod|END_ENTITY	Anticoagulant and calcium-binding properties of high molecular weight derivatives of human fibrinogen , produced by plasmin -LRB- fragments X -RRB- .
7798686	0	plasmin	68,75	fibrinogen	11,21	plasmin	fibrinogen	5340	2244	Gene	Gene	acquisition|nmod|START_ENTITY END_ENTITY|nmod|acquisition	A role for fibrinogen in the streptokinase-dependent acquisition of plasmin -LRB- ogen -RRB- by group A streptococci .
9679953	0	plasmin	101,108	matrix_metalloproteinase-2	54,80	plasmin	matrix metalloproteinase-2	5340	4313	Gene	Gene	degradation|nmod|START_ENTITY END_ENTITY|nmod|degradation	Tissue_inhibitor_of_metalloproteinase-2 protection of matrix_metalloproteinase-2 from degradation by plasmin is reversed by divalent cation chelator EDTA and the bisphosphonate_alendronate .
15659039	0	plasmin	92,99	plasminogen_activator_inhibitor-1	101,134	plasmin	plasminogen activator inhibitor-1	5340	5054	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Cultured pressure ulcer fibroblasts show replicative senescence with elevated production of plasmin , plasminogen_activator_inhibitor-1 , and transforming_growth_factor-beta1 .
8367835	0	plasmin	99,106	plasminogen_activator_inhibitor-1	12,45	plasmin	plasminogen activator inhibitor-1	5340	5054	Gene	Gene	effects|nmod|START_ENTITY platelets|nmod|effects protects|dobj|platelets protects|nsubj|END_ENTITY	Recombinant plasminogen_activator_inhibitor-1 protects platelets against the inhibitory effects of plasmin .
8091390	0	plasmin	50,57	protein_C	37,46	plasmin	protein C	5340	5554	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation and inactivation of human protein_C by plasmin .
1376317	0	plasmin	205,212	vitronectin	92,103	plasmin	vitronectin	5340	7448	Gene	Gene	formation|compound|START_ENTITY control|nmod|formation mechanism|nmod|control reveals|dobj|mechanism reveals|nsubj|Mapping Mapping|nmod|sites sites|nmod|heparin heparin|nmod|region region|nmod:poss|END_ENTITY	Mapping of binding sites for heparin , plasminogen_activator_inhibitor-1 , and plasminogen to vitronectin 's heparin-binding region reveals a novel vitronectin-dependent feedback mechanism for the control of plasmin formation .
7678553	0	plasmin	56,63	vitronectin	81,92	plasmin	vitronectin	5340	7448	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Synthetic peptides derived from the sequence around the plasmin cleavage site in vitronectin .
8612645	0	plasmin	8,15	vitronectin	31,42	plasmin	vitronectin	5340	7448	Gene	Gene	proteolysis|compound|START_ENTITY proteolysis|nmod|END_ENTITY	Limited plasmin proteolysis of vitronectin .
9030777	0	plasmin	88,95	vitronectin	19,30	plasmin	vitronectin	5340	7448	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|Phosphorylation Phosphorylation|nmod|END_ENTITY	Phosphorylation of vitronectin on Ser362 by protein_kinase_C attenuates its cleavage by plasmin .
9667615	0	plasmin	70,77	vitronectin	92,103	plasmin	vitronectin	5340	7448	Gene	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Vitronectin expression in rheumatoid arthritic synovia -- inhibition of plasmin generation by vitronectin produced in vitro .
17030725	0	plasminogen	68,79	PLG	81,84	plasminogen	PLG	5340	5340	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ligneous_conjunctivitis in a Mexican patient with a mutation in the plasminogen -LRB- PLG -RRB- gene .
26360520	0	plasminogen	101,112	PLG	114,117	plasminogen	PLG	403602(Tax:9615)	403602(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ligneous membranitis in Scottish Terriers is associated with a single nucleotide polymorphism in the plasminogen -LRB- PLG -RRB- gene .
8767722	0	plasminogen	20,31	PLG	33,36	plasminogen	PLG	5340	5340	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of plasminogen -LRB- PLG -RRB- polymorphism in the Namibian !
1654795	0	plasminogen	23,34	Plasmin	0,7	plasminogen	Plasmin	5340	5340	Gene	Gene	receptor|compound|START_ENTITY binding|nmod|receptor binding|compound|END_ENTITY	Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding .
9116283	0	plasminogen	14,25	interleukin-6	45,58	plasminogen	interleukin-6	5340	3569	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of plasminogen gene expression by interleukin-6 .
25407528	0	plasminogen	37,48	plasminogen	5,16	plasminogen	plasminogen	5340	5340	Gene	Gene	receptors|compound|START_ENTITY role|nmod|receptors role|nmod|END_ENTITY	From plasminogen to plasmin : role of plasminogen receptors in human cancer .
25407528	0	plasminogen	5,16	plasminogen	37,48	plasminogen	plasminogen	5340	5340	Gene	Gene	role|nmod|START_ENTITY role|nmod|receptors receptors|compound|END_ENTITY	From plasminogen to plasmin : role of plasminogen receptors in human cancer .
10880342	0	plasminogen-activator_inhibitor_type-1	50,88	PAI-1	90,95	plasminogen-activator inhibitor type-1	PAI-1	5054	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sp1-like activity mediates angiotensin-II-induced plasminogen-activator_inhibitor_type-1 -LRB- PAI-1 -RRB- gene expression in mesangial cells .
26438258	0	plasminogen_activator	23,44	pla	4,7	plasminogen activator	pla	15151870	13917718	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The pla gene , encoding plasminogen_activator , is not specific to Yersinia_pestis .
2418059	0	plasminogen_activator-inhibitor	22,53	Thrombin	0,8	plasminogen activator-inhibitor	Thrombin	5054	2147	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Thrombin induction of plasminogen_activator-inhibitor in cultured human endothelial cells .
7642963	0	plasminogen_activator-inhibitor-1	14,47	PAI-1	49,54	plasminogen activator-inhibitor-1	PAI-1	24617(Tax:10116)	24617(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of plasminogen_activator-inhibitor-1 -LRB- PAI-1 -RRB- during cellular remodeling in proliferative glomerulonephritis in the rat .
2515610	0	plasminogen_activator_inhibitor	17,48	PAI	50,53	plasminogen activator inhibitor	PAI	5054	5054	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Determination of plasminogen_activator_inhibitor -LRB- PAI -RRB- activity of human plasma after dilution in a PAI-depleted plasma .
8435984	0	plasminogen_activator_inhibitor	55,86	PAI-1	88,93	plasminogen activator inhibitor	PAI-1	5054	5054	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Insulin therapy in type 2 diabetic subjects suppresses plasminogen_activator_inhibitor -LRB- PAI-1 -RRB- activity and proinsulin-like molecules independently of glycaemic control .
3140909	0	plasminogen_activator_inhibitor	50,81	Tumor_necrosis_factor	0,21	plasminogen activator inhibitor	Tumor necrosis factor	5054	7124	Gene	Gene	production|nmod|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Tumor_necrosis_factor increases the production of plasminogen_activator_inhibitor in human endothelial cells in vitro and in rats in vivo .
1436316	0	plasminogen_activator_inhibitor	8,39	tumor_necrosis_factor	87,108	plasminogen activator inhibitor	tumor necrosis factor	24617(Tax:10116)	103694380	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of plasminogen_activator_inhibitor on nephrotoxic_nephritis and its modulation by tumor_necrosis_factor .
1491687	0	plasminogen_activator_inhibitor-1	28,61	Angiotensin-II	0,14	plasminogen activator inhibitor-1	Angiotensin-II	24617(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Angiotensin-II induction of plasminogen_activator_inhibitor-1 gene expression in astroglial cells of normotensive and spontaneously hypertensive rat brain .
12021572	0	plasminogen_activator_inhibitor-1	58,91	Angiotensin_II	0,14	plasminogen activator inhibitor-1	Angiotensin II	5054	183	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells stimulate|dobj|expression stimulate|nsubj|END_ENTITY	Angiotensin_II and IV stimulate expression and release of plasminogen_activator_inhibitor-1 in cultured human coronary artery endothelial cells .
1537291	0	plasminogen_activator_inhibitor-1	30,63	Angiotensin_II	0,14	plasminogen activator inhibitor-1	Angiotensin II	24617(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulation|nmod|expression stimulation|compound|END_ENTITY	Angiotensin_II stimulation of plasminogen_activator_inhibitor-1 gene expression in astroglial cells from the brain .
19246637	0	plasminogen_activator_inhibitor-1	29,62	Angiotensin_II	0,14	plasminogen activator inhibitor-1	Angiotensin II	24617(Tax:10116)	24179(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces renal plasminogen_activator_inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R. Angiotensin -LRB- Ang -RRB- II-induced fibrosis of the kidney is characterized by the enhanced expression of profibrotic and proinflammatory genes , including the serine protease inhibitor plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- and cyclooxygenase-2 -LRB- COX-2 -RRB- .
7884001	0	plasminogen_activator_inhibitor-1	43,76	Angiotensin_II	0,14	plasminogen activator inhibitor-1	Angiotensin II	5054	183	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates the expression of plasminogen_activator_inhibitor-1 in cultured endothelial cells .
8641204	0	plasminogen_activator_inhibitor-1	29,62	Angiotensin_II	0,14	plasminogen activator inhibitor-1	Angiotensin II	24617(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Angiotensin_II regulation of plasminogen_activator_inhibitor-1 gene expression in neurons of normotensive and spontaneously hypertensive rat brains .
9241756	0	plasminogen_activator_inhibitor-1	25,58	Angiotensin_II	0,14	plasminogen activator inhibitor-1	Angiotensin II	24617(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases plasminogen_activator_inhibitor-1 and tissue factor mRNA expression without changing that of tissue type plasminogen activator or tissue_factor_pathway_inhibitor in cultured rat aortic endothelial cells .
17949793	0	plasminogen_activator_inhibitor-1	29,62	C-reactive_protein	0,18	plasminogen activator inhibitor-1	C-reactive protein	5054	1401	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	C-reactive_protein increases plasminogen_activator_inhibitor-1 expression in human endothelial cells .
16879222	0	plasminogen_activator_inhibitor-1	55,88	C5a	25,28	plasminogen activator inhibitor-1	C5a	5054	728	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The complement component C5a induces the expression of plasminogen_activator_inhibitor-1 in human macrophages via NF-kappaB activation .
14644771	0	plasminogen_activator_inhibitor-1	79,112	ERK1/2	128,134	plasminogen activator inhibitor-1	ERK1/2	5054	5595;5594	Gene	Gene	START_ENTITY|acl|activating activating|dobj|END_ENTITY	Increased vascular_endothelial_growth_factor may account for elevated level of plasminogen_activator_inhibitor-1 via activating ERK1/2 in keloid fibroblasts .
20136501	0	plasminogen_activator_inhibitor-1	20,53	FOXO4	0,5	plasminogen activator inhibitor-1	FOXO4	5054	4303	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	FOXO4 induces human plasminogen_activator_inhibitor-1 gene expression via an indirect mechanism by modulating HIF-1alpha and CREB levels .
20522601	0	plasminogen_activator_inhibitor-1	31,64	HDL3	0,4	plasminogen activator inhibitor-1	HDL3	5054	53369	Gene	Gene	release|amod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	HDL3 , but not HDL2 , stimulates plasminogen_activator_inhibitor-1 release from adipocytes : the role of sphingosine-1-phosphate .
16914534	0	plasminogen_activator_inhibitor-1	32,65	IL-1	0,4	plasminogen activator inhibitor-1	IL-1	18787(Tax:10090)	111343(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	IL-1 and IL-6 induce hepatocyte plasminogen_activator_inhibitor-1 expression through independent signaling pathways converging on C/EBPdelta .
10102472	0	plasminogen_activator_inhibitor-1	18,51	IL-1beta	66,74	plasminogen activator inhibitor-1	IL-1beta	5054	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The activation of plasminogen_activator_inhibitor-1 expression by IL-1beta is attenuated by estrogen in hepatoblastoma HepG2 cells expressing estrogen_receptor_alpha .
26164207	0	plasminogen_activator_inhibitor-1	15,48	LRP1	86,90	plasminogen activator inhibitor-1	LRP1	5054	4035	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|recruitment recruitment|nmod|cells cells|nummod|END_ENTITY	Glioma-derived plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- regulates the recruitment of LRP1 positive mast cells .
26555266	0	plasminogen_activator_inhibitor-1	34,67	LRP1	134,138	plasminogen activator inhibitor-1	LRP1	5054	4035	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The high-affinity binding site on plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- for the low density lipoprotein receptor-related protein -LRB- LRP1 -RRB- is composed of four basic residues .
19540572	0	plasminogen_activator_inhibitor-1	32,65	Nox4	0,4	plasminogen activator inhibitor-1	Nox4	5054	50507	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Nox4 mediates the expression of plasminogen_activator_inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells .
10436140	0	plasminogen_activator_inhibitor-1	137,170	PAI-1	172,177	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Clinical implications of elevated PAI-1 revisited : multiple arterial_thrombosis in a patient with essential thrombocythemia and elevated plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels : a case report and review of the literature .
10494774	0	plasminogen_activator_inhibitor-1	18,51	PAI-1	53,58	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regular exercise , plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- activity and the 4G/5G promoter polymorphism in the PAI-1 gene .
11164859	0	plasminogen_activator_inhibitor-1	27,60	PAI-1	62,67	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vitamins_C_and_E attenuate plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in a hypercholesterolemic_porcine_model_of_angioplasty .
11244954	0	plasminogen_activator_inhibitor-1	19,52	PAI-1	54,59	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- The expression of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene in human astrocytomas -RSB- .
11470783	0	plasminogen_activator_inhibitor-1	82,115	PAI-1	117,122	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene by the alkylating agent N-methyl-N ' - nitro-N-nitrosoguanidine .
11972486	0	plasminogen_activator_inhibitor-1	26,59	PAI-1	61,66	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism 4G/5G in the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene is associated with IgE-mediated allergic_diseases and asthma in the Czech population .
12501010	0	plasminogen_activator_inhibitor-1	53,86	PAI-1	88,93	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cerivastatin , a HMG-CoA_reductase inhibitor , reduces plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in endothelial cells by down-regulation of cellular signaling and the inhibition of PAI-1 promoter activity .
12745658	0	plasminogen_activator_inhibitor-1	8,41	PAI-1	43,48	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Role of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels in the diagnosis of BMT-associated hepatic_veno-occlusive_disease and monitoring of subsequent therapy with defibrotide -LRB- DF -RRB- .
15191349	0	plasminogen_activator_inhibitor-1	39,72	PAI-1	74,79	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The prevalence of 4G5G polymorphism of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene in polycystic_ovarian_syndrome and its association with plasma PAI-1 levels .
15673060	0	plasminogen_activator_inhibitor-1	151,184	PAI-1	186,191	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of perindopril treatment on hemostatic function in patients with essential hypertension in relation to angiotensin_converting_enzyme -LRB- ACE -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene polymorphisms .
15745938	0	plasminogen_activator_inhibitor-1	92,125	PAI-1	127,132	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Testosterone does not adversely affect fibrinogen or tissue_plasminogen_activator -LRB- tPA -RRB- and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels in 46 men with chronic_stable_angina .
15950223	0	plasminogen_activator_inhibitor-1	88,121	PAI-1	123,128	plasminogen activator inhibitor-1	PAI-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Involvement of circadian clock gene Clock in diabetes-induced circadian augmentation of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in the mouse heart .
17848179	0	plasminogen_activator_inhibitor-1	8,41	PAI-1	43,48	plasminogen activator inhibitor-1	PAI-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	Chronic plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- overexpression dampens CD25 + lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung .
17848179	0	plasminogen_activator_inhibitor-1	8,41	PAI-1	43,48	plasminogen activator inhibitor-1	PAI-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	overexpression|amod|START_ENTITY overexpression|compound|END_ENTITY	Chronic plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- overexpression dampens CD25 + lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung .
17938813	0	plasminogen_activator_inhibitor-1	33,66	PAI-1	68,73	plasminogen activator inhibitor-1	PAI-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Food deprivation induces adipose plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression without accumulation of plasma PAI-1 in genetically obese and diabetic db/db mice .
17961204	0	plasminogen_activator_inhibitor-1	141,174	PAI-1	176,181	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Fish-oil esters of plant sterols differ from vegetable-oil sterol_esters in triglycerides lowering , carotenoid bioavailability and impact on plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- concentrations in hypercholesterolemic subjects .
19351570	0	plasminogen_activator_inhibitor-1	47,80	PAI-1	40,45	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Prognostic value of pre-surgical plasma PAI-1 -LRB- plasminogen_activator_inhibitor-1 -RRB- levels in breast_cancer .
1960012	0	plasminogen_activator_inhibitor-1	57,90	PAI-1	92,97	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Inverse relationship between cortisol excretion rate and plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- antigen and activity in premenopausal_obese women .
19728713	0	plasminogen_activator_inhibitor-1	49,82	PAI-1	84,89	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A citrus extract containing flavanones represses plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression and regulates multiple inflammatory , tissue repair , and fibrosis genes in human colon fibroblasts .
20216986	0	plasminogen_activator_inhibitor-1	40,73	PAI-1	75,80	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The adaptor protein Ruk/CIN85 activates plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression via hypoxia-inducible_factor-1alpha .
22078208	0	plasminogen_activator_inhibitor-1	57,90	PAI-1	92,97	plasminogen activator inhibitor-1	PAI-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Novel regulatory mechanism and functional implication of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression in CpG-ODN-stimulated macrophages .
24446892	0	plasminogen_activator_inhibitor-1	40,73	PAI-1	75,80	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The prevalence of 4G/5G polymorphism of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene in central serous_chorioretinopathy and its association with plasma PAI-1 levels .
24596353	0	plasminogen_activator_inhibitor-1	7,40	PAI-1	42,47	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Plasma plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels in breast_cancer - relationship with clinical outcome .
25723084	0	plasminogen_activator_inhibitor-1	30,63	PAI-1	65,70	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 4G/4G polymorphism of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene as an independent risk factor for placental_insufficiency , which triggers fetal hemodynamic centralization .
26456097	0	plasminogen_activator_inhibitor-1	130,163	PAI-1	165,170	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-a induced human aortic endothelial cell migration and decrease plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- levels .
3142242	0	plasminogen_activator_inhibitor-1	13,46	PAI-1	48,53	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	Reduction|nmod|START_ENTITY Reduction|appos|END_ENTITY	Reduction in plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- with omega-3_polyunsaturated_fatty_acid -LRB- PUFA -RRB- intake .
7740466	0	plasminogen_activator_inhibitor-1	13,46	PAI-1	48,53	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Detection of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- mRNA in human megakaryocytes by in situ hybridization .
8388372	0	plasminogen_activator_inhibitor-1	73,106	PAI-1	108,113	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The two allele sequences of a common polymorphism in the promoter of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene respond differently to interleukin-1 in HepG2 cells .
8571307	0	plasminogen_activator_inhibitor-1	54,87	PAI-1	89,94	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 4G/5G genetic polymorphism in the promoter of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene is associated with differences in plasma PAI-1 activity but not with risk of myocardial_infarction in the ECTIM study .
8852783	0	plasminogen_activator_inhibitor-1	28,61	PAI-1	63,68	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	-LSB- Prognostic significance of plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- in primary breast_carcinoma -RSB- .
9358004	0	plasminogen_activator_inhibitor-1	31,64	PAI-1	66,71	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differential regulation of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene expression by growth factors and progesterone in human endometrial stromal cells .
9569196	0	plasminogen_activator_inhibitor-1	42,75	PAI-1	77,82	plasminogen activator inhibitor-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common 4G allele in the promoter of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene as a risk factor for pulmonary_embolism and arterial_thrombosis in hereditary_protein_S_deficiency .
15631825	0	plasminogen_activator_inhibitor-1	67,100	PPARalpha	38,47	plasminogen activator inhibitor-1	PPARalpha	5054	5465	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	-LSB- An exploratory study on mechanism of PPARalpha activators-induced plasminogen_activator_inhibitor-1 expression in HepG-2 cells -RSB- .
22798504	0	plasminogen_activator_inhibitor-1	13,46	SERPINE1	48,56	plasminogen activator inhibitor-1	SERPINE1	5054	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Influence of plasminogen_activator_inhibitor-1 -LRB- SERPINE1 -RRB- 4G/5G polymorphism on circulating SERPINE-1 antigen expression in HCC associated with viral_infection .
10208482	0	plasminogen_activator_inhibitor-1	14,47	TNF-alpha	84,93	plasminogen activator inhibitor-1	TNF-alpha	5054	7124	Gene	Gene	tissue|amod|START_ENTITY Expression|nmod|tissue Expression|dep|role role|nmod|END_ENTITY	Expression of plasminogen_activator_inhibitor-1 in human adipose tissue : a role for TNF-alpha ?
10362602	0	plasminogen_activator_inhibitor-1	57,90	TNF-alpha	0,9	plasminogen activator inhibitor-1	TNF-alpha	5054	7124	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	TNF-alpha and insulin , alone and synergistically , induce plasminogen_activator_inhibitor-1 expression in adipocytes .
12527424	0	plasminogen_activator_inhibitor-1	27,60	TNF-alpha	91,100	plasminogen activator inhibitor-1	TNF-alpha	18787(Tax:10090)	21926(Tax:10090)	Gene	Gene	converting|amod|START_ENTITY converting|amod|END_ENTITY	Differential expression of plasminogen_activator_inhibitor-1 , tumor_necrosis_factor-alpha , TNF-alpha converting enzyme and ADAMTS family members in murine fat territories .
15677734	0	plasminogen_activator_inhibitor-1	36,69	TNF-alpha	0,9	plasminogen activator inhibitor-1	TNF-alpha	5054	7124	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	TNF-alpha , but not IL-6 , stimulates plasminogen_activator_inhibitor-1 expression in human subcutaneous adipose tissue .
10625711	0	plasminogen_activator_inhibitor-1	98,131	Tissue_plasminogen_activator	0,28	plasminogen activator inhibitor-1	Tissue plasminogen activator	5054	100128998	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	Tissue_plasminogen_activator , plasminogen_activator_inhibitor-1 , and tissue_plasminogen_activator / plasminogen_activator_inhibitor-1 complex as risk factors for the development of a first stroke .
17014662	0	plasminogen_activator_inhibitor-1	41,74	Transforming_growth_factor-beta3	0,32	plasminogen activator inhibitor-1	Transforming growth factor-beta3	18787(Tax:10090)	21809(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY affects|dobj|expression affects|nsubj|END_ENTITY	Transforming_growth_factor-beta3 affects plasminogen_activator_inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction .
9048615	0	plasminogen_activator_inhibitor-1	38,71	Tumor_necrosis_factor-alpha	0,27	plasminogen activator inhibitor-1	Tumor necrosis factor-alpha	24617(Tax:10116)	24835(Tax:10116)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates plasminogen_activator_inhibitor-1 in rat testicular peritubular cells .
14581407	0	plasminogen_activator_inhibitor-1	20,53	angiotensin_II	86,100	plasminogen activator inhibitor-1	angiotensin II	18787(Tax:10090)	11606(Tax:10090)	Gene	Gene	mediator|dep|START_ENTITY mediator|nmod|END_ENTITY	Aldosterone and not plasminogen_activator_inhibitor-1 is a critical mediator of early angiotensin_II / NG-nitro-L-arginine_methyl_ester-induced myocardial_injury .
19051364	0	plasminogen_activator_inhibitor-1	30,63	angiotensin_II	97,111	plasminogen activator inhibitor-1	angiotensin II	24617(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|amod|START_ENTITY depresses|dobj|production depresses|nmod|inhibition inhibition|nmod|END_ENTITY	Salvia miltiorrhiza depresses plasminogen_activator_inhibitor-1 production through inhibition of angiotensin_II .
20216986	0	plasminogen_activator_inhibitor-1	40,73	hypoxia-inducible_factor-1alpha	97,128	plasminogen activator inhibitor-1	hypoxia-inducible factor-1alpha	5054	3091	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The adaptor protein Ruk/CIN85 activates plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- expression via hypoxia-inducible_factor-1alpha .
15968405	0	plasminogen_activator_inhibitor-1	30,63	insulin-like_growth_factor-1	78,106	plasminogen activator inhibitor-1	insulin-like growth factor-1	5054	3479	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcriptional regulation of plasminogen_activator_inhibitor-1 expression by insulin-like_growth_factor-1 via MAP kinases and hypoxia-inducible_factor-1 in HepG2 cells .
1989604	0	plasminogen_activator_inhibitor-1	41,74	interleukin-1	18,31	plasminogen activator inhibitor-1	interleukin-1	5054	3552	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Recombinant human interleukin-1 inhibits plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- production by human articular cartilage and chondrocytes .
11470783	0	plasminogen_activator_inhibitor-1	82,115	p53	0,3	plasminogen activator inhibitor-1	p53	5054	7157	Gene	Gene	gene|amod|START_ENTITY induction|nmod|gene required|nmod|induction required|nsubjpass|Phosphorylation Phosphorylation|compound|END_ENTITY	p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen_activator_inhibitor-1 -LRB- PAI-1 -RRB- gene by the alkylating agent N-methyl-N ' - nitro-N-nitrosoguanidine .
15735814	0	plasminogen_activator_inhibitor-1	77,110	p53	154,157	plasminogen activator inhibitor-1	p53	18787(Tax:10090)	22060(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY activates|dobj|gene activates|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	The alkylating carcinogen N-methyl-N ' - nitro-N-nitrosoguanidine activates the plasminogen_activator_inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases .
18469003	0	plasminogen_activator_inhibitor-1	14,47	p53	87,90	plasminogen activator inhibitor-1	p53	5054	7157	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of plasminogen_activator_inhibitor-1 expression by tumor suppressor protein p53 .
15659039	0	plasminogen_activator_inhibitor-1	101,134	plasmin	92,99	plasminogen activator inhibitor-1	plasmin	5054	5340	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Cultured pressure ulcer fibroblasts show replicative senescence with elevated production of plasmin , plasminogen_activator_inhibitor-1 , and transforming_growth_factor-beta1 .
8367835	0	plasminogen_activator_inhibitor-1	12,45	plasmin	99,106	plasminogen activator inhibitor-1	plasmin	5054	5340	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|platelets platelets|nmod|effects effects|nmod|END_ENTITY	Recombinant plasminogen_activator_inhibitor-1 protects platelets against the inhibitory effects of plasmin .
9230112	0	plasminogen_activator_inhibitor-1	78,111	thrombin	127,135	plasminogen activator inhibitor-1	thrombin	5054	2147	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|END_ENTITY	The cluster of basic amino_acids in vitronectin contributes to its binding of plasminogen_activator_inhibitor-1 : evidence from thrombin - , elastase - and plasmin-cleaved vitronectins and anti-peptide antibodies .
11385207	0	plasminogen_activator_inhibitor-1	26,59	tissue-type_plasminogen_activator	108,141	plasminogen activator inhibitor-1	tissue-type plasminogen activator	5054	5327	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	4G/5G polymorphism of the plasminogen_activator_inhibitor-1 gene and insertion/deletion polymorphism of the tissue-type_plasminogen_activator gene in atherothrombotic_stroke .
1601844	0	plasminogen_activator_inhibitor-1	54,87	tissue-type_plasminogen_activator	129,162	plasminogen activator inhibitor-1	tissue-type plasminogen activator	5054	5327	Gene	Gene	form|nmod|START_ENTITY Identification|nmod|form acting|nsubj|Identification acting|nmod|substrate substrate|nmod|END_ENTITY	Identification of a conformationally distinct form of plasminogen_activator_inhibitor-1 , acting as a noninhibitory substrate for tissue-type_plasminogen_activator .
1648385	0	plasminogen_activator_inhibitor-1	116,149	tissue-type_plasminogen_activator	81,114	plasminogen activator inhibitor-1	tissue-type plasminogen activator	5054	5327	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Role of protein kinase C and cyclic_adenosine_monophosphate in the regulation of tissue-type_plasminogen_activator , plasminogen_activator_inhibitor-1 , and platelet-derived growth factor mRNA levels in human endothelial cells .
7662701	0	plasminogen_activator_inhibitor-1	106,139	tissue-type_plasminogen_activator	72,105	plasminogen activator inhibitor-1	tissue-type plasminogen activator	5054	5327	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Cathepsin_D-like aspartyl protease activity mediates the degradation of tissue-type_plasminogen_activator / plasminogen_activator_inhibitor-1 complexes in human monocytes .
9256087	0	plasminogen_activator_inhibitor-1	124,157	tissue-type_plasminogen_activator	174,207	plasminogen activator inhibitor-1	tissue-type plasminogen activator	5054	5327	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells : astragaloside_IV downregulates plasminogen_activator_inhibitor-1 and upregulates tissue-type_plasminogen_activator expression .
11138573	0	plasminogen_activator_inhibitor-1	112,145	tissue_plasminogen_activator	44,72	plasminogen activator inhibitor-1	tissue plasminogen activator	5054	100128998	Gene	Gene	complexes|amod|START_ENTITY /|dobj|complexes /|nsubj|END_ENTITY	Acute psychological_stress_decreases plasma tissue_plasminogen_activator -LRB- tPA -RRB- and tissue_plasminogen_activator / plasminogen_activator_inhibitor-1 -LRB- tPA/PAI -1 -RRB- complexes in cardiac patients .
11570875	0	plasminogen_activator_inhibitor-1	108,141	tissue_plasminogen_activator	148,176	plasminogen activator inhibitor-1	tissue plasminogen activator	5054	100128998	Gene	Gene	Resolution|amod|START_ENTITY Resolution|nmod|END_ENTITY	Resolution of Michaelis complex , acylation , and conformational change steps in the reactions of the serpin , plasminogen_activator_inhibitor-1 , with tissue_plasminogen_activator and trypsin .
18922856	0	plasminogen_activator_inhibitor-1	80,113	tissue_plasminogen_activator	29,57	plasminogen activator inhibitor-1	tissue plasminogen activator	5054	100128998	Gene	Gene	cells|amod|START_ENTITY Unique|nmod|cells Unique|dobj|dynamics dynamics|nmod|END_ENTITY	Unique secretory dynamics of tissue_plasminogen_activator and its modulation by plasminogen_activator_inhibitor-1 in vascular endothelial cells .
1951323	0	plasminogen_activator_inhibitor-1	60,93	tissue_plasminogen_activator	20,48	plasminogen activator inhibitor-1	tissue plasminogen activator	5054	100128998	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Increased levels of tissue_plasminogen_activator with a low plasminogen_activator_inhibitor-1 in a patient with postoperative_bleeding .
21193004	0	plasminogen_activator_inhibitor-1	149,182	tissue_plasminogen_activator	23,51	plasminogen activator inhibitor-1	tissue plasminogen activator	24617(Tax:10116)	25692(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|activity activity|compound|END_ENTITY	Biphasic regulation of tissue_plasminogen_activator activity in ischemic rat brain and in cultured neural cells : essential role of astrocyte-derived plasminogen_activator_inhibitor-1 .
3139401	0	plasminogen_activator_inhibitor-1	18,51	tissue_plasminogen_activator	66,94	plasminogen activator inhibitor-1	tissue plasminogen activator	5054	100128998	Gene	Gene	START_ENTITY|nmod|mutants mutants|nmod|END_ENTITY	Neutralization by plasminogen_activator_inhibitor-1 of mutants of tissue_plasminogen_activator .
9136968	0	plasminogen_activator_inhibitor-1	89,122	tissue_plasminogen_activator	38,66	plasminogen activator inhibitor-1	tissue plasminogen activator	5054	100128998	Gene	Gene	Protection|nmod|START_ENTITY Protection|nmod|alpha2-macroglobulin alpha2-macroglobulin|nmod|END_ENTITY	Protection by alpha2-macroglobulin of tissue_plasminogen_activator against inhibition by plasminogen_activator_inhibitor-1 .
11054406	0	plasminogen_activator_inhibitor-1	14,47	transforming_growth_factor-beta	62,93	plasminogen activator inhibitor-1	transforming growth factor-beta	5054	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of plasminogen_activator_inhibitor-1 expression by transforming_growth_factor-beta - induced physical and functional interactions between smads and Sp1 .
12781036	0	plasminogen_activator_inhibitor-1	56,89	transforming_growth_factor_beta1	15,47	plasminogen activator inhibitor-1	transforming growth factor beta1	5054	7040	Gene	Gene	induced|xcomp|START_ENTITY END_ENTITY|acl|induced	Rhein inhibits transforming_growth_factor_beta1 induced plasminogen_activator_inhibitor-1 in endothelial cells .
12527424	0	plasminogen_activator_inhibitor-1	27,60	tumor_necrosis_factor-alpha	62,89	plasminogen activator inhibitor-1	tumor necrosis factor-alpha	18787(Tax:10090)	21926(Tax:10090)	Gene	Gene	converting|amod|START_ENTITY converting|amod|END_ENTITY	Differential expression of plasminogen_activator_inhibitor-1 , tumor_necrosis_factor-alpha , TNF-alpha converting enzyme and ADAMTS family members in murine fat territories .
23789212	0	plasminogen_activator_inhibitor-1	78,111	tumor_necrosis_factor-alpha	49,76	plasminogen activator inhibitor-1	tumor necrosis factor-alpha	5054	7124	Gene	Gene	C-reactive_protein|amod|START_ENTITY C-reactive_protein|amod|END_ENTITY	Perilla oil and exercise decrease expressions of tumor_necrosis_factor-alpha , plasminogen_activator_inhibitor-1 and highly sensitive C-reactive_protein in patients with hyperlipidemia .
10831181	0	plasminogen_activator_inhibitor-1	79,112	tumor_necrosis_factor_alpha	10,37	plasminogen activator inhibitor-1	tumor necrosis factor alpha	5054	7124	Gene	Gene	secretion|amod|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor_alpha and transforming_growth_factor_beta_1 on plasminogen_activator_inhibitor-1 secretion from subcutaneous and omental human fat cells in suspension culture .
9718068	0	plasminogen_activator_inhibitor-1	93,126	u-PA	139,143	plasminogen activator inhibitor-1	u-PA	5054	5328	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Synoviocytes from osteoarthritis and rheumatoid_arthritis produce plasminogen activators and plasminogen_activator_inhibitor-1 and display u-PA receptors on their surface .
21199867	0	plasminogen_activator_inhibitor-1	76,109	urokinase-type_plasminogen_activator	36,72	plasminogen activator inhibitor-1	urokinase-type plasminogen activator	5054	5328	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recognition of urokinase-type_plasminogen_activator by plasminogen_activator_inhibitor-1 .
7482411	0	plasminogen_activator_inhibitor-1	48,81	vitronectin	18,29	plasminogen activator inhibitor-1	vitronectin	5054	7448	Gene	Gene	region|nmod|START_ENTITY region|compound|END_ENTITY	Localization of a vitronectin binding region of plasminogen_activator_inhibitor-1 .
10411006	0	plasminogen_activator_inhibitor-2	18,51	PAI-2	53,58	plasminogen activator inhibitor-2	PAI-2	18788(Tax:10090)	18788(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of the plasminogen_activator_inhibitor-2 -LRB- PAI-2 -RRB- gene in murine macrophages .
12225871	0	plasminogen_activator_inhibitor-2	92,125	PAI-2	127,132	plasminogen activator inhibitor-2	PAI-2	18788(Tax:10090)	18788(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Plasminogen mRNA induction in the mouse brain after kainate excitation : codistribution with plasminogen_activator_inhibitor-2 -LRB- PAI-2 -RRB- mRNA .
20494554	0	plasminogen_activator_inhibitor-2	8,41	PAI-2	43,48	plasminogen activator inhibitor-2	PAI-2	5055	5055	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of plasminogen_activator_inhibitor-2 -LRB- PAI-2 -RRB- in keratinocyte differentiation .
3149048	0	plasminogen_activator_inhibitor_1	36,69	Insulin	0,7	plasminogen activator inhibitor 1	Insulin	5054	3630	Gene	Gene	synthesis|nmod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Insulin stimulates the synthesis of plasminogen_activator_inhibitor_1 by the human hepatocellular cell line Hep G2 .
10971410	0	plasminogen_activator_inhibitor_1	77,110	PAI-1	112,117	plasminogen activator inhibitor 1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 4G/4G genotype at nucleotide position -675 in the promotor region of the plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- gene is less frequent in young patients with minor_stroke than in controls .
12506026	0	plasminogen_activator_inhibitor_1	37,70	PAI-1	72,77	plasminogen activator inhibitor 1	PAI-1	5054	5054	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Direct binding of Nur77/NAK -1 to the plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- promoter regulates TNF_alpha - induced PAI-1 expression .
1384159	0	plasminogen_activator_inhibitor_1	27,60	PAI-1	62,67	plasminogen activator inhibitor 1	PAI-1	5054	5054	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Progesterone regulation of plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- antigen and mRNA levels in human endometrial stromal cells .
21719525	0	plasminogen_activator_inhibitor_1	36,69	PAI-1	71,76	plasminogen activator inhibitor 1	PAI-1	5054	5054	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Role of fibrinolytic parameters and plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- promoter polymorphism on premature atherosclerosis in SLE patients .
22038782	0	plasminogen_activator_inhibitor_1	75,108	PAI-1	110,115	plasminogen activator inhibitor 1	PAI-1	5054	5054	Gene	Gene	production|amod|START_ENTITY production|dep|END_ENTITY	Xanthoangelols isolated from Angelica keiskei inhibit inflammatory-induced plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- production .
9139722	0	plasminogen_activator_inhibitor_1	68,101	Proteinase	0,10	plasminogen activator inhibitor 1	Proteinase	5054	100616101	Gene	Gene	mutants|nmod|START_ENTITY END_ENTITY|nmod|mutants	Proteinase specificity and functional diversity in point mutants of plasminogen_activator_inhibitor_1 .
14592829	0	plasminogen_activator_inhibitor_1	41,74	Thymosin_beta_4	0,15	plasminogen activator inhibitor 1	Thymosin beta 4	5054	7114	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Thymosin_beta_4 induces the synthesis of plasminogen_activator_inhibitor_1 in cultured endothelial cells and increases its extracellular expression .
9531054	0	plasminogen_activator_inhibitor_1	72,105	angiotensin_II	117,131	plasminogen activator inhibitor 1	angiotensin II	24617(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Atrial_natriuretic_peptide inhibits the expression of tissue factor and plasminogen_activator_inhibitor_1 induced by angiotensin_II in cultured rat aortic endothelial cells .
11303186	0	plasminogen_activator_inhibitor_1	14,47	epidermal_growth_factor	77,100	plasminogen activator inhibitor 1	epidermal growth factor	5054	1950	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of plasminogen_activator_inhibitor_1 expression by interaction of epidermal_growth_factor with progestin during decidualization of human endometrial stromal cells .
9746723	0	plasminogen_activator_inhibitor_1	82,115	urokinase_plasminogen_activator	50,81	plasminogen activator inhibitor 1	urokinase plasminogen activator	5054	5328	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|dep|complex	Human endothelial cell migration is stimulated by urokinase_plasminogen_activator : plasminogen_activator_inhibitor_1 complex released from endometrial stromal cells stimulated with transforming_growth_factor_beta1 ; possible mechanism for paracrine stimulation of endometrial angiogenesis .
7523190	0	plasminogen_activator_inhibitor_1	49,82	vitronectin	21,32	plasminogen activator inhibitor 1	vitronectin	5054	7448	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Determination of the vitronectin binding site on plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- .
9241752	0	plasminogen_activator_inhibitor_2	37,70	PAI-2	72,77	plasminogen activator inhibitor 2	PAI-2	5055	5055	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation , location and activity of plasminogen_activator_inhibitor_2 -LRB- PAI-2 -RRB- in peripheral blood monocytes , macrophages and foam cells .
11460477	0	plasminogen_activator_inhibitor_2	57,90	fibrinogen	42,52	plasminogen activator inhibitor 2	fibrinogen	5055	2244	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of crosslinking sites in fibrinogen for plasminogen_activator_inhibitor_2 -LRB- PAI-2 -RRB- .
15493875	0	plasminogen_activator_inhibitor_type-1	42,80	Non-muscle_alpha-actinin-4	0,26	plasminogen activator inhibitor type-1	Non-muscle alpha-actinin-4	5054	81	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Non-muscle_alpha-actinin-4 interacts with plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- .
17663760	0	plasminogen_activator_inhibitor_type-1	13,51	PAI-1	53,58	plasminogen activator inhibitor type-1	PAI-1	5054	5054	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- by hypoxia and irradiation in human head_and_neck_carcinoma cell lines .
19144865	0	plasminogen_activator_inhibitor_type-1	24,62	PAI-1	64,69	plasminogen activator inhibitor type-1	PAI-1	18787(Tax:10090)	18787(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	A profibrotic effect of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- in the heart .
21240498	0	plasminogen_activator_inhibitor_type-1	28,66	PAI-1	68,73	plasminogen activator inhibitor type-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- gene 4G/5G polymorphism and osteoarthritis .
3130610	0	plasminogen_activator_inhibitor_type-1	35,73	PAI-1	75,80	plasminogen activator inhibitor type-1	PAI-1	5054	5054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The regulatory region of the human plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- gene .
8261243	0	plasminogen_activator_inhibitor_type-1	29,67	PAI-1	69,74	plasminogen activator inhibitor type-1	PAI-1	5054	5054	Gene	Gene	biosynthesis|nmod|START_ENTITY biosynthesis|appos|END_ENTITY	Constitutive biosynthesis of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- by cultured human aortic endothelial cells independent of insulin .
10073956	0	plasminogen_activator_inhibitor_type-1	58,96	PPARgamma	0,9	plasminogen activator inhibitor type-1	PPARgamma	5054	5468	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|activation activation|compound|END_ENTITY	PPARgamma activation in human endothelial cells increases plasminogen_activator_inhibitor_type-1 expression : PPARgamma as a potential mediator in vascular_disease .
10073956	0	plasminogen_activator_inhibitor_type-1	58,96	PPARgamma	109,118	plasminogen activator inhibitor type-1	PPARgamma	5054	5468	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	PPARgamma activation in human endothelial cells increases plasminogen_activator_inhibitor_type-1 expression : PPARgamma as a potential mediator in vascular_disease .
7775119	0	plasminogen_activator_inhibitor_type-1	40,78	Transforming_growth_factor-beta	0,31	plasminogen activator inhibitor type-1	Transforming growth factor-beta	5054	7040	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-beta induces plasminogen_activator_inhibitor_type-1 in cultured human orbital fibroblasts .
1309426	0	plasminogen_activator_inhibitor_type-1	25,63	thrombin	83,91	plasminogen activator inhibitor type-1	thrombin	5054	2147	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells induction|nmod|END_ENTITY	Synergistic induction of plasminogen_activator_inhibitor_type-1 in HEP G2 cells by thrombin and transforming_growth_factor-beta .
8063785	0	plasminogen_activator_inhibitor_type-1	99,137	transforming_growth_factor-beta	41,72	plasminogen activator inhibitor type-1	transforming growth factor-beta	5054	7040	Gene	Gene	gene|amod|START_ENTITY element|nmod|gene element|amod|responsive responsive|advmod|END_ENTITY	A novel protein interacts with the major transforming_growth_factor-beta responsive element in the plasminogen_activator_inhibitor_type-1 gene .
15116265	0	plasminogen_activator_inhibitor_type_1	36,74	Adiponectin	0,11	plasminogen activator inhibitor type 1	Adiponectin	5054	9370	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Adiponectin is inversely related to plasminogen_activator_inhibitor_type_1 in patients with stable exertional angina .
17172275	0	plasminogen_activator_inhibitor_type_1	70,108	Akt	45,48	plasminogen activator inhibitor type 1	Akt	5054	207	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Phosphatidylinositol_3-kinase / protein kinase Akt negatively regulates plasminogen_activator_inhibitor_type_1 expression in vascular endothelial cells .
12802648	0	plasminogen_activator_inhibitor_type_1	13,51	CO2	0,3	plasminogen activator inhibitor type 1	CO2	5054	717	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	CO2 promotes plasminogen_activator_inhibitor_type_1 expression in human mesothelial cells .
8805664	0	plasminogen_activator_inhibitor_type_1	51,89	IFN-gamma	0,9	plasminogen activator inhibitor type 1	IFN-gamma	5054	3458	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IFN-gamma inhibits thrombin - and endotoxin-induced plasminogen_activator_inhibitor_type_1 in human endothelial cells .
17433639	0	plasminogen_activator_inhibitor_type_1	42,80	PAI-1	82,87	plasminogen activator inhibitor type 1	PAI-1	5054	5054	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	C-reactive_protein is directly related to plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene .
24695040	0	plasminogen_activator_inhibitor_type_1	24,62	PAI-1	64,69	plasminogen activator inhibitor type 1	PAI-1	5054	5054	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The association between plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- levels , PAI-1 4G/5G polymorphism , and myocardial_infarction : a Mendelian randomization meta-analysis .
9126661	0	plasminogen_activator_inhibitor_type_1	30,68	PAI-1	70,75	plasminogen activator inhibitor type 1	PAI-1	5054	5054	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Proinsulin-like molecules and plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- activity in diabetic and non-diabetic subjects with and without myocardial_infarction .
9355235	0	plasminogen_activator_inhibitor_type_1	43,81	PAI-1	83,88	plasminogen activator inhibitor type 1	PAI-1	5054	5054	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunoelectron microscopic localization of plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- in smooth muscle cells from morphologically normal and atherosclerotic human arteries .
14534369	0	plasminogen_activator_inhibitor_type_1	54,92	Tumor_necrosis_factor-alpha	0,27	plasminogen activator inhibitor type 1	Tumor necrosis factor-alpha	5054	7124	Gene	Gene	production|amod|START_ENTITY END_ENTITY|dobj|production	Tumor_necrosis_factor-alpha and troglitazone_regulate plasminogen_activator_inhibitor_type_1 production through extracellular_signal-regulated_kinase - and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells .
8980646	0	plasminogen_activator_inhibitor_type_1	37,75	factor_Xa	24,33	plasminogen activator inhibitor type 1	factor Xa	5054	2159	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	The inhibition of human factor_Xa by plasminogen_activator_inhibitor_type_1 in the presence of calcium ion , and its enhancement by heparin and vitronectin .
10075998	0	plasminogen_activator_inhibitor_type_2	37,75	PAI-2	77,82	plasminogen activator inhibitor type 2	PAI-2	5055	5055	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	An AU-rich sequence in the 3 ' - UTR of plasminogen_activator_inhibitor_type_2 -LRB- PAI-2 -RRB- mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR .
9037208	0	plasminogen_activator_inhibitor_type_2	42,80	PAI-2	82,87	plasminogen activator inhibitor type 2	PAI-2	5055	5055	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Urokinase-mediated transactivation of the plasminogen_activator_inhibitor_type_2 -LRB- PAI-2 -RRB- gene promoter in HT-1080 cells utilises AP-1 binding sites and potentiates phorbol_ester-mediated induction of endogenous PAI-2 mRNA .
9780231	0	plasminogen_activator_inhibitor_type_2	68,106	PAI-2	108,113	plasminogen activator inhibitor type 2	PAI-2	5055	5055	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNase I hypersensitive sites in the 5 ' flanking region of the human plasminogen_activator_inhibitor_type_2 -LRB- PAI-2 -RRB- gene are associated with basal and tumor_necrosis_factor-alpha-induced transcription in monocytes .
8870712	0	platelet-activating_factor	21,47	IL-4	13,17	platelet-activating factor	IL-4	9768	3565	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of IL-4 by platelet-activating_factor .
10533051	0	platelet-activating_factor	137,163	Interleukin-1_beta	0,18	platelet-activating factor	Interleukin-1 beta	300795(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
8613706	0	platelet-activating_factor	50,76	Interleukin-6	0,13	platelet-activating factor	Interleukin-6	9768	3569	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates neutrophil production of platelet-activating_factor .
14611633	0	platelet-activating_factor	10,36	PAF	38,41	platelet-activating factor	PAF	9768	9768	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of platelet-activating_factor -LRB- PAF -RRB- on stallion sperm motility , capacitation and the acrosome reaction .
1794301	0	platelet-activating_factor	11,37	PAF	39,42	platelet-activating factor	PAF	9768	9768	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of platelet-activating_factor -LRB- PAF -RRB- from human colon mucosa and its inhibition by 5-aminosalicylic_acid .
1819722	0	platelet-activating_factor	12,38	PAF	40,43	platelet-activating factor	PAF	9768	9768	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of platelet-activating_factor -LRB- PAF -RRB- in experimental glomerular_injury .
1819735	0	platelet-activating_factor	15,41	PAF	43,46	platelet-activating factor	PAF	9768	9768	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of platelet-activating_factor -LRB- PAF -RRB- in septic_shock and priming as indicated by the effect of hetrazepinoic_PAF antagonists .
2519900	0	platelet-activating_factor	26,52	PAF	54,57	platelet-activating factor	PAF	9768	9768	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated plasma levels of platelet-activating_factor -LRB- PAF -RRB- in breast_cancer patients with hypercalcemia .
2536413	0	platelet-activating_factor	14,40	PAF	42,45	platelet-activating factor	PAF	9768	9768	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of platelet-activating_factor -LRB- PAF -RRB- - induced chemotaxis and PAF binding to human eosinophils and neutrophils by the specific ginkgolide-derived PAF antagonist , BN_52021 .
2703999	0	platelet-activating_factor	8,34	PAF	36,39	platelet-activating factor	PAF	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of platelet-activating_factor -LRB- PAF -RRB- in the initiation of the decidual reaction in the rat .
6253571	0	platelet-activating_factor	26,52	PAF	54,57	platelet-activating factor	PAF	9768	9768	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and release of platelet-activating_factor -LRB- PAF -RRB- ; dissociation from degranulation and superoxide production in the human neutrophil .
7981886	0	platelet-activating_factor	12,38	PAF	40,43	platelet-activating factor	PAF	9768	9768	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of platelet-activating_factor -LRB- PAF -RRB- in interstitial_pulmonary_disease .
8358021	0	platelet-activating_factor	15,41	PAF	43,46	platelet-activating factor	PAF	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of platelet-activating_factor -LRB- PAF -RRB- in endotoxin - or ischaemia-induced intestinal hyperpermeability in the rat .
8390724	0	platelet-activating_factor	16,42	PAF	11,14	platelet-activating factor	PAF	9768	9768	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of PAF -LRB- platelet-activating_factor -RRB- on hemostasis .
8655220	0	platelet-activating_factor	18,44	PAF	46,49	platelet-activating factor	PAF	9768	9768	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	The production of platelet-activating_factor -LRB- PAF -RRB- during hemodialysis with cuprophane membrane .
9890553	0	platelet-activating_factor	14,40	PAF	42,45	platelet-activating factor	PAF	9768	9768	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Heterogeneous platelet-activating_factor -LRB- PAF -RRB- receptors and calcium increase in platelets and macrophages .
9892046	0	platelet-activating_factor	36,62	PAF	64,67	platelet-activating factor	PAF	109585(Tax:10090)	109585(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Effect of Y-24180 , an antagonist at platelet-activating_factor -LRB- PAF -RRB- receptors , on IgE-mediated cutaneous reactions in mice .
8507159	0	platelet-activating_factor	28,54	PAFAH	96,101	platelet-activating factor	PAFAH	9768	7941	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Increased plasma levels of platelet-activating_factor -LRB- PAF -RRB- and low serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adult patients with bronchial_asthma -RSB- .
8833165	0	platelet-activating_factor	26,52	PAFAH	100,105	platelet-activating factor	PAFAH	9768	7941	Gene	Gene	level|nmod|START_ENTITY PAF_acetylhydrolase|nsubj|level PAF_acetylhydrolase|parataxis|END_ENTITY	Increased plasma level of platelet-activating_factor -LRB- PAF -RRB- and decreased serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adults with bronchial_asthma .
8507159	0	platelet-activating_factor	28,54	PAF_acetylhydrolase	75,94	platelet-activating factor	PAF acetylhydrolase	9768	7941	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	-LSB- Increased plasma levels of platelet-activating_factor -LRB- PAF -RRB- and low serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adult patients with bronchial_asthma -RSB- .
8833165	0	platelet-activating_factor	26,52	PAF_acetylhydrolase	79,98	platelet-activating factor	PAF acetylhydrolase	9768	7941	Gene	Gene	level|nmod|START_ENTITY END_ENTITY|nsubj|level	Increased plasma level of platelet-activating_factor -LRB- PAF -RRB- and decreased serum PAF_acetylhydrolase -LRB- PAFAH -RRB- activity in adults with bronchial_asthma .
10533051	0	platelet-activating_factor	137,163	cyclooxygenase-2	194,210	platelet-activating factor	cyclooxygenase-2	300795(Tax:10116)	29527(Tax:10116)	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|expression expression|amod|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
10533051	0	platelet-activating_factor	137,163	cyclooxygenase-2	43,59	platelet-activating factor	cyclooxygenase-2	300795(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Interleukin-1_beta activates expression of cyclooxygenase-2 and inducible_nitric_oxide_synthase in primary hippocampal neuronal culture : platelet-activating_factor as a preferential mediator of cyclooxygenase-2 expression .
1356028	0	platelet-activating_factor	100,126	intercellular_adhesion_molecule-1	22,55	platelet-activating factor	intercellular adhesion molecule-1	9768	3383	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Possible induction of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression on endothelial cells by platelet-activating_factor -LRB- PAF -RRB- .
2117030	0	platelet-activating_factor	15,41	interferon-gamma	47,63	platelet-activating factor	interferon-gamma	9768	3458	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of platelet-activating_factor with interferon-gamma in the stimulation of interleukin-1 production by human monocytes .
9227331	0	platelet-activating_factor	56,82	interleukin-8	34,47	platelet-activating factor	interleukin-8	9768	3576	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Transcriptional activation of the interleukin-8 gene by platelet-activating_factor in human peripheral blood monocytes .
10781653	0	platelet-activating_factor_acetylhydrolase	28,70	PAF-AH	72,78	platelet-activating factor acetylhydrolase	PAF-AH	5048	5048	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Correlations between plasma platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity and PAF-AH genotype , age , and atherosclerosis in a Japanese population .
11580924	0	platelet-activating_factor_acetylhydrolase	6,48	PAF-AH	50,56	platelet-activating factor acetylhydrolase	PAF-AH	5048	5048	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Serum platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity in more than 3000 healthy Japanese .
12787800	0	platelet-activating_factor_acetylhydrolase	6,48	PAF-AH	50,56	platelet-activating factor acetylhydrolase	PAF-AH	5048	5048	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Serum platelet-activating_factor_acetylhydrolase -LRB- PAF-AH -RRB- activity in patients with hyperbilirubinemic_hepatobiliary_disease .
10643587	0	platelet-activating_factor_acetylhydrolase	55,97	interleukin-8	21,34	platelet-activating factor acetylhydrolase	interleukin-8	7941	3576	Gene	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	Inhibitory effect of interleukin-8 on the secretion of platelet-activating_factor_acetylhydrolase by human decidual macrophages .
14500680	0	platelet-activating_factor_receptor	33,68	Janus_kinase_2	0,14	platelet-activating factor receptor	Janus kinase 2	5724	3717	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Janus_kinase_2 activation by the platelet-activating_factor_receptor -LRB- PAFR -RRB- : roles of Tyk2 and PAFR C terminus .
23260771	0	platelet-activating_factor_receptor	12,47	PAFR	49,53	platelet-activating factor receptor	PAFR	19204(Tax:10090)	19204(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of platelet-activating_factor_receptor -LRB- PAFR -RRB- in lung pathology during experimental malaria .
12420294	0	platelet-activating_factor_receptor	64,99	PAFr	101,105	platelet-activating factor receptor	PAFr	5724	5724	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal location , structure , and temporal expression of the platelet-activating_factor_receptor -LRB- PAFr -RRB- gene in porcine endometrium and embryos relative to estrogen_receptor_alpha gene expression .
9920107	0	platelet-derived_endothelial_cell_growth_factor	14,61	PD-ECGF	63,70	platelet-derived endothelial cell growth factor	PD-ECGF	1890	1890	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of platelet-derived_endothelial_cell_growth_factor -LRB- PD-ECGF -RRB- related to angiogenesis in ovarian_endometriosis .
12118322	0	platelet-derived_endothelial_cell_growth_factor	14,61	thymidine_phosphorylase	62,85	platelet-derived endothelial cell growth factor	thymidine phosphorylase	1890	1890	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of platelet-derived_endothelial_cell_growth_factor / thymidine_phosphorylase in cervical_intraepithelial_neoplasia .
12644837	0	platelet-derived_endothelial_cell_growth_factor	8,55	thymidine_phosphorylase	56,79	platelet-derived endothelial cell growth factor	thymidine phosphorylase	1890	1890	Gene	Gene	Role|nmod|START_ENTITY Role|dep|END_ENTITY	Role of platelet-derived_endothelial_cell_growth_factor / thymidine_phosphorylase in fluoropyrimidine sensitivity .
8226792	0	platelet-derived_growth_factor	31,61	PDGF	63,67	platelet-derived growth factor	PDGF	397765(Tax:8355)	397765(Tax:8355)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Dominant-negative mutations of platelet-derived_growth_factor -LRB- PDGF -RRB- receptors .
9527059	0	platelet-derived_growth_factor-A	20,52	PDGF-A	54,60	platelet-derived growth factor-A	PDGF-A	5154	5154	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of platelet-derived_growth_factor-A -LRB- PDGF-A -RRB- in gastric_carcinoma .
18583239	0	platelet-derived_growth_factor-B	27,59	Angiotensin_II	1,15	platelet-derived growth factor-B	Angiotensin II	5155	183	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	-LSB- Angiotensin_II stimulates platelet-derived_growth_factor-B expression in hepatic stellate cells by activating EGR-1 -RSB- .
8403516	0	platelet-derived_growth_factor-B	37,69	PDGF-B	71,77	platelet-derived growth factor-B	PDGF-B	5155	5155	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Up-regulation of alveolar macrophage platelet-derived_growth_factor-B -LRB- PDGF-B -RRB- mRNA by interferon-gamma from Mycobacterium tuberculosis antigen -LRB- PPD -RRB- - stimulated lymphocytes .
8403516	0	platelet-derived_growth_factor-B	37,69	interferon-gamma	87,103	platelet-derived growth factor-B	interferon-gamma	5155	3458	Gene	Gene	mRNA|amod|START_ENTITY mRNA|nmod|END_ENTITY	Up-regulation of alveolar macrophage platelet-derived_growth_factor-B -LRB- PDGF-B -RRB- mRNA by interferon-gamma from Mycobacterium tuberculosis antigen -LRB- PPD -RRB- - stimulated lymphocytes .
18925432	0	platelet-derived_growth_factor-C	25,57	PDGF-C	59,65	platelet-derived growth factor-C	PDGF-C	56034	56034	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The molecular cloning of platelet-derived_growth_factor-C -LRB- PDGF-C -RRB- gene of Gekko japonicus and its expression change in the spinal cord after tail amputation .
16977580	0	platelet-derived_growth_factor-alpha	13,49	PDGF-A	51,57	platelet-derived growth factor-alpha	PDGF-A	25266(Tax:10116)	25266(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Detection of platelet-derived_growth_factor-alpha -LRB- PDGF-A -RRB- protein in cells of Leydig lineage in the postnatal rat testis .
7535092	0	platelet-derived_growth_factor_A	103,135	WT1	36,39	platelet-derived growth factor A	WT1	5154	7490	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Expression of the Wilms ' _ tumor gene WT1 in human malignant_mesothelioma cell lines and relationship to platelet-derived_growth_factor_A and insulin-like_growth_factor_2 expression .
2649516	0	platelet-derived_growth_factor_A-chain	13,51	angiotensin_II	82,96	platelet-derived growth factor A-chain	angiotensin II	25266(Tax:10116)	24179(Tax:10116)	Gene	Gene	expressions|amod|START_ENTITY expressions|nmod|END_ENTITY	Induction of platelet-derived_growth_factor_A-chain and c-myc gene expressions by angiotensin_II in cultured rat vascular smooth muscle cells .
8621696	0	platelet-derived_growth_factor_B-chain	59,97	c-sis	99,104	platelet-derived growth factor B-chain	c-sis	5155	5155	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Identification of a thrombin response element in the human platelet-derived_growth_factor_B-chain -LRB- c-sis -RRB- promoter .
8621696	0	platelet-derived_growth_factor_B-chain	59,97	thrombin	20,28	platelet-derived growth factor B-chain	thrombin	5155	2147	Gene	Gene	promoter|amod|START_ENTITY Identification|nmod|promoter Identification|nmod|element element|compound|END_ENTITY	Identification of a thrombin response element in the human platelet-derived_growth_factor_B-chain -LRB- c-sis -RRB- promoter .
10828062	0	platelet-derived_growth_factor_B-chain	13,51	transforming_growth_factor-beta	66,97	platelet-derived growth factor B-chain	transforming growth factor-beta	5155	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of platelet-derived_growth_factor_B-chain expression by transforming_growth_factor-beta involves transactivation by Smads .
10938893	0	platelet-derived_growth_factor_B_chain	28,66	c-sis	68,73	platelet-derived growth factor B chain	c-sis	5155	5155	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Translational regulation of platelet-derived_growth_factor_B_chain -LRB- c-sis -RRB- mRNA by short open reading frames in the 5 ' - untranslated region .
16189269	0	platelet-derived_growth_factor_D-chain	10,48	angiotensin_II	63,77	platelet-derived growth factor D-chain	angiotensin II	80310	183	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inducible platelet-derived_growth_factor_D-chain expression by angiotensin_II and hydrogen_peroxide involves transcriptional regulation by Ets-1 and Sp1 .
7546776	0	platelet-derived_growth_factor_alpha-receptor	94,139	IL-1_beta	20,29	platelet-derived growth factor alpha-receptor	IL-1 beta	25267(Tax:10116)	24494(Tax:10116)	Gene	Gene	upregulate|dobj|START_ENTITY upregulate|nsubj|END_ENTITY	Interleukin_1_beta -LRB- IL-1_beta -RRB- and the IL-1_beta-alpha_2-macroglobulin complex upregulate the platelet-derived_growth_factor_alpha-receptor on rat pulmonary fibroblasts .
8530514	0	platelet-derived_growth_factor_alpha-receptor	75,120	alpha_2-macroglobulin	30,51	platelet-derived growth factor alpha-receptor	alpha 2-macroglobulin	25267(Tax:10116)	24153(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Native and activated forms of alpha_2-macroglobulin increase expression of platelet-derived_growth_factor_alpha-receptor in vascular smooth muscle cells .
12149261	0	platelet-derived_growth_factor_receptor	87,126	PDGF-r	128,134	platelet-derived growth factor receptor	PDGF-r	5159	5159	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Insight into the role of low_molecular_weight_phosphotyrosine_phosphatase -LRB- LMW-PTP -RRB- on platelet-derived_growth_factor_receptor -LRB- PDGF-r -RRB- signaling .
10850862	0	platelet-derived_growth_factor_receptor-A	21,62	PDGFRA	64,70	platelet-derived growth factor receptor-A	PDGFRA	5156	5156	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Amplification of the platelet-derived_growth_factor_receptor-A -LRB- PDGFRA -RRB- gene occurs in oligodendrogliomas with grade IV anaplastic features .
25205714	0	platelet-derived_growth_factor_receptor-a	18,59	miR-126	0,7	platelet-derived growth factor receptor-a	miR-126	5156	406913	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	miR-126 regulates platelet-derived_growth_factor_receptor-a expression and migration of primary human osteoblasts .
14593115	0	platelet-derived_growth_factor_receptor-alpha	37,82	Fibroblast_growth_factor-2	0,26	platelet-derived growth factor receptor-alpha	Fibroblast growth factor-2	5156	2247	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	Fibroblast_growth_factor-2 represses platelet-derived_growth_factor_receptor-alpha -LRB- PDGFR-alpha -RRB- transcription via ERK1/2-dependent Sp1 phosphorylation and an atypical cis-acting element in the proximal PDGFR-alpha promoter .
16804324	0	platelet-derived_growth_factor_receptor-alpha	30,75	PDGFRalpha	77,87	platelet-derived growth factor receptor-alpha	PDGFRalpha	5156	5156	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variant in promoter region of platelet-derived_growth_factor_receptor-alpha -LRB- PDGFRalpha -RRB- gene is associated with the severity and allergic status of childhood_asthma .
16569213	0	platelet-derived_growth_factor_receptor-beta	69,113	Angiotensin_II	0,14	platelet-derived growth factor receptor-beta	Angiotensin II	5159	183	Gene	Gene	phosphorylation|nmod|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates phosphorylation of an ectodomain-truncated platelet-derived_growth_factor_receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells .
12381737	0	platelet-derived_growth_factor_receptor-beta	23,67	G_protein-coupled_receptor_kinase-2	108,143	platelet-derived growth factor receptor-beta	G protein-coupled receptor kinase-2	5159	156	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of the platelet-derived_growth_factor_receptor-beta and epidermal_growth_factor_receptor by G_protein-coupled_receptor_kinase-2 .
15994317	0	platelet-derived_growth_factor_receptor-beta	4,48	G_protein-coupled_receptor_kinase-2	78,113	platelet-derived growth factor receptor-beta	G protein-coupled receptor kinase-2	5159	156	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The platelet-derived_growth_factor_receptor-beta phosphorylates and activates G_protein-coupled_receptor_kinase-2 .
21729646	0	platelet-derived_growth_factor_receptor-beta	38,82	PDGFR-b	84,91	platelet-derived growth factor receptor-beta	PDGFR-b	5159	5159	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Immunohistochemical overexpression of platelet-derived_growth_factor_receptor-beta -LRB- PDGFR-b -RRB- is associated with PDGFRB gene copy number gain in sarcomatoid_non-small-cell_lung_cancer .
20510677	0	platelet-derived_growth_factor_receptor-beta	34,78	ZNF24	119,124	platelet-derived growth factor receptor-beta	ZNF24	5159	7572	Gene	Gene	repression|nmod|START_ENTITY repression|nmod|END_ENTITY	The transcriptional repression of platelet-derived_growth_factor_receptor-beta by the zinc finger transcription factor ZNF24 .
12890682	0	platelet-derived_growth_factor_receptor-beta	80,124	phospholipase_D2	15,31	platelet-derived growth factor receptor-beta	phospholipase D2	5159	5338	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of phospholipase_D2 in lysophosphatidate-induced transactivation of platelet-derived_growth_factor_receptor-beta in human bronchial epithelial cells .
21596750	0	platelet-derived_growth_factor_receptor_alpha	155,200	Casitas_B_lineage_lymphoma	4,30	platelet-derived growth factor receptor alpha	Casitas B lineage lymphoma	5156	867	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	The Casitas_B_lineage_lymphoma -LRB- Cbl -RRB- mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived_growth_factor_receptor_alpha and fibroblast_growth_factor_receptor_2 ubiquitination .
16354679	0	platelet-derived_growth_factor_receptor_alpha	19,64	Galpha12	109,117	platelet-derived growth factor receptor alpha	Galpha12	5156	2768	Gene	Gene	START_ENTITY|nmod|mutant mutant|nmod|END_ENTITY	Transactivation of platelet-derived_growth_factor_receptor_alpha by the GTPase-deficient activated mutant of Galpha12 .
18686281	0	platelet-derived_growth_factor_receptor_alpha	53,98	PDGFRA	100,106	platelet-derived growth factor receptor alpha	PDGFRA	5156	5156	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inflammatory fibroid_polyps harbour mutations in the platelet-derived_growth_factor_receptor_alpha -LRB- PDGFRA -RRB- gene .
22907756	0	platelet-derived_growth_factor_receptor_b	17,58	p19Arf	0,6	platelet-derived growth factor receptor b	p19Arf	18596(Tax:10090)	12578(Tax:10090)	Gene	Gene	represses|xcomp|START_ENTITY represses|nsubj|END_ENTITY	p19Arf represses platelet-derived_growth_factor_receptor_b by transcriptional and posttranscriptional mechanisms .
12542482	0	platelet-derived_growth_factor_receptor_beta	38,82	PDGFRB	84,90	platelet-derived growth factor receptor beta	PDGFRB	5159	5159	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Novel translocations that disrupt the platelet-derived_growth_factor_receptor_beta -LRB- PDGFRB -RRB- gene in BCR-ABL-negative chronic_myeloproliferative_disorders .
18262053	0	platelet-derived_growth_factor_receptor_beta	34,78	PDGFRB	85,91	platelet-derived growth factor receptor beta	PDGFRB	5159	5159	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fusion of PRKG2 and SPTBN1 to the platelet-derived_growth_factor_receptor_beta gene -LRB- PDGFRB -RRB- in imatinib-responsive atypical myeloproliferative_disorders .
9066919	0	platelet-endothelial_cell_adhesion_molecule-1	14,59	PECAM	61,66	platelet-endothelial cell adhesion molecule-1	PECAM	5175	5175	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM -RRB- by macaque trophoblast cells during invasion of the spiral arteries .
11795274	0	platelet-endothelial_cell_adhesion_molecule-1	21,66	PECAM-1	68,75	platelet-endothelial cell adhesion molecule-1	PECAM-1	5175	5175	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- gene , Asn563Ser and Gly670Arg , associated with myocardial_infarction in the Japanese .
17607964	0	platelet-endothelial_cell_adhesion_molecule-1	95,140	PECAM-1	142,149	platelet-endothelial cell adhesion molecule-1	PECAM-1	5175	5175	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
7507944	0	platelet-endothelial_cell_adhesion_molecule-1	14,59	PECAM-1	61,68	platelet-endothelial cell adhesion molecule-1	PECAM-1	5175	5175	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- during melanoma-induced angiogenesis in vivo .
9789258	0	platelet-endothelial_cell_adhesion_molecule-1	27,72	PECAM-1	74,81	platelet-endothelial cell adhesion molecule-1	PECAM-1	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- in murine tissues .
9243511	0	platelet-endothelial_cell_adhesion_molecule-1	65,110	Thrombospondin-1	0,16	platelet-endothelial cell adhesion molecule-1	Thrombospondin-1	18613(Tax:10090)	21825(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Thrombospondin-1 , a natural inhibitor of angiogenesis , regulates platelet-endothelial_cell_adhesion_molecule-1 expression and endothelial cell morphogenesis .
3490673	0	platelet_activating_factor	25,51	Interleukin_1	0,13	platelet activating factor	Interleukin 1	9768	3552	Gene	Gene	production|compound|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin_1 stimulates platelet_activating_factor production in cultured human endothelial cells .
15735601	0	platelet_activating_factor	17,43	PAF	45,48	platelet activating factor	PAF	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Direct action of platelet_activating_factor -LRB- PAF -RRB- induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis .
1843897	0	platelet_activating_factor	11,37	PAF	39,42	platelet activating factor	PAF	9768	9768	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of platelet_activating_factor -LRB- PAF -RRB- on granulocyte migration in vivo in patients with atopic_asthma -RSB- .
2554526	0	platelet_activating_factor	75,101	PAF	70,73	platelet activating factor	PAF	9768	9768	Gene	Gene	receptors|appos|START_ENTITY receptors|compound|END_ENTITY	Sheep platelets as a model for human platelets : evidence for specific PAF -LRB- platelet_activating_factor -RRB- receptors .
3402585	0	platelet_activating_factor	11,37	PAF	39,42	platelet activating factor	PAF	9768	9768	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of platelet_activating_factor -LRB- PAF -RRB- on human citrated whole blood .
3619905	0	platelet_activating_factor	22,48	PAF	50,53	platelet activating factor	PAF	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Spasmogenic effect of platelet_activating_factor -LRB- PAF -RRB- on isolated rat stomach fundus strip .
3947392	1	platelet_activating_factor	51,77	PAF	79,82	platelet activating factor	PAF	9768	9768	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of platelet_activating_factor -LRB- PAF -RRB- with human serum alpha-1-acid glycoprotein -LRB- AAG -RRB- .
6482659	0	platelet_activating_factor	10,36	PAF	38,41	platelet activating factor	PAF	300795(Tax:10116)	300795(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of platelet_activating_factor -LRB- PAF -RRB- on blood flow distribution in the spontaneously hypertensive rat .
8655890	0	platelet_activating_factor	82,108	myeloperoxidase	34,49	platelet activating factor	myeloperoxidase	9768	4353	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Nasal neutrophilia and release of myeloperoxidase induced by nasal challenge with platelet_activating_factor : different degrees of responsiveness in atopic and nonatopic subjects .
1476872	0	platelet_activating_factor	51,77	thyroglobulin	16,29	platelet activating factor	thyroglobulin	9768	7038	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effect of human thyroglobulin on the production of platelet_activating_factor from peripheral blood mononuclear cells from patients with autoimmune_thyroid_diseases .
6695148	0	platelet_aggregating_factor	37,64	PAF	32,35	platelet aggregating factor	PAF	9768	9768	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of the pure synthetic PAF -LRB- platelet_aggregating_factor -RRB- on clot retraction and platelet_aggregation .
11604562	0	platelet_collagen_receptor	12,38	glycoprotein_Ia	40,55	platelet collagen receptor	glycoprotein Ia	51206	22915	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of platelet_collagen_receptor -LRB- glycoprotein_Ia / IIa ; integrin alpha2 beta1 -RRB- polymorphisms in thrombotic_disease .
16136272	0	platelet_derived_growth_factor-B	46,78	Hypoxia_inducible_factor_1-alpha	0,32	platelet derived growth factor-B	Hypoxia inducible factor 1-alpha	5155	3091	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Hypoxia_inducible_factor_1-alpha regulates of platelet_derived_growth_factor-B in human glioblastoma cells .
24535964	0	platelet_derived_growth_factor_receptor-beta	18,62	PDGFRb	64,70	platelet derived growth factor receptor-beta	PDGFRb	5159	5159	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Image analysis of platelet_derived_growth_factor_receptor-beta -LRB- PDGFRb -RRB- expression to determine the grade and dynamics of myelofibrosis in bone marrow biopsy samples .
24810671	0	platelet_derived_growth_factor_receptor-beta	18,62	PDGFRb	64,70	platelet derived growth factor receptor-beta	PDGFRb	5159	5159	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Image analysis of platelet_derived_growth_factor_receptor-beta -LRB- PDGFRb -RRB- expression to determine the grade and dynamics of myelofibrosis in bone marrow biopsy samples .
14688220	0	platelet_endothelial_cell_adhesion_molecule	32,75	PECAM-1	77,84	platelet endothelial cell adhesion molecule	PECAM-1	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of platelet_endothelial_cell_adhesion_molecule -LRB- PECAM-1 , CD31 -RRB- in vascular endothelium .
21564091	0	platelet_endothelial_cell_adhesion_molecule	62,105	interleukin-10	121,135	platelet endothelial cell adhesion molecule	interleukin-10	29583(Tax:10116)	25325(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Nitric_oxide modulates lipopolysaccharide-induced endothelial platelet_endothelial_cell_adhesion_molecule expression via interleukin-10 .
17580308	0	platelet_endothelial_cell_adhesion_molecule-1	64,109	CD177	32,37	platelet endothelial cell adhesion molecule-1	CD177	5175	57126	Gene	Gene	counter-receptor|nmod|START_ENTITY counter-receptor|nsubj|END_ENTITY	The neutrophil-specific antigen CD177 is a counter-receptor for platelet_endothelial_cell_adhesion_molecule-1 -LRB- CD31 -RRB- .
15786495	0	platelet_endothelial_cell_adhesion_molecule-1	22,67	CD31	77,81	platelet endothelial cell adhesion molecule-1	CD31	18613(Tax:10090)	18613(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Kinetic expression of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 / CD31 -RRB- during embryonic_stem cell differentiation .
18243211	0	platelet_endothelial_cell_adhesion_molecule-1	32,77	Coupling_factor_6	0,17	platelet endothelial cell adhesion molecule-1	Coupling factor 6	5175	522	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	Coupling_factor_6 downregulates platelet_endothelial_cell_adhesion_molecule-1 via c-Src activation and acts as a proatherogenic molecule .
22396143	0	platelet_endothelial_cell_adhesion_molecule-1	16,61	ICAM-1	111,117	platelet endothelial cell adhesion molecule-1	ICAM-1	5175	3383	Gene	Gene	expressions|amod|START_ENTITY expressions|appos|END_ENTITY	Significance of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expressions in preeclamptic placentae .
9084985	0	platelet_endothelial_cell_adhesion_molecule-1	28,73	PECAM-1	75,82	platelet endothelial cell adhesion molecule-1	PECAM-1	282303(Tax:9913)	282303(Tax:9913)	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Tyrosine phosphorylation of platelet_endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- in mechanically stimulated vascular endothelial cells .
18243211	0	platelet_endothelial_cell_adhesion_molecule-1	32,77	c-Src	82,87	platelet endothelial cell adhesion molecule-1	c-Src	5175	6714	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Coupling_factor_6 downregulates platelet_endothelial_cell_adhesion_molecule-1 via c-Src activation and acts as a proatherogenic molecule .
8879215	0	platelet_endothelial_cell_adhesion_molecule_1	27,72	Interferon_gamma	0,16	platelet endothelial cell adhesion molecule 1	Interferon gamma	18613(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interferon_gamma regulates platelet_endothelial_cell_adhesion_molecule_1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas .
15591119	0	platelet_factor_4	83,100	LRP	109,112	platelet factor 4	LRP	5196	4035	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	Endothelial expression of E-selectin is induced by the platelet-specific chemokine platelet_factor_4 through LRP in an NF-kappaB-dependent manner .
2881257	0	platelet_factor_4	34,51	PF4	53,56	platelet factor 4	PF4	5196	5196	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An Eco R1 polymorphism of a human platelet_factor_4 -LRB- PF4 -RRB- gene .
3570037	0	platelet_factor_4	32,49	PF4	51,54	platelet factor 4	PF4	5196	5196	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Raised plasma concentrations of platelet_factor_4 -LRB- PF4 -RRB- in Crohn 's _ disease .
6743573	0	platelet_factor_4	14,31	PF4	33,36	platelet factor 4	PF4	5196	5196	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of platelet_factor_4 -LRB- PF4 -RRB- on assays of plasma heparin .
2968397	0	platelet_factor_4	31,48	beta-thromboglobulin	7,27	platelet factor 4	beta-thromboglobulin	5196	5473	Gene	Gene	ratios|amod|START_ENTITY END_ENTITY|nmod|ratios	Plasma beta-thromboglobulin to platelet_factor_4 ratios as indices of vascular_complications in essential hypertension .
1665594	0	platelet_factor_4	109,126	factor_Xa	55,64	platelet factor 4	factor Xa	5196	2159	Gene	Gene	effect|nmod|START_ENTITY weight|dep|effect weight|acl|heparin-catalyzed heparin-catalyzed|dobj|inactivation inactivation|nmod|END_ENTITY	Low molecular weight heparin-catalyzed inactivation of factor_Xa and thrombin by antithrombin III -- effect of platelet_factor_4 .
1329921	0	platelet_factor_4	116,133	thrombin	14,22	platelet factor 4	thrombin	5196	2147	Gene	Gene	absence|nmod|START_ENTITY heparins|nmod|absence heparins|nsubj|Inhibition Inhibition|nmod|generation generation|compound|END_ENTITY	Inhibition of thrombin generation by heparin and low molecular weight -LRB- LMW -RRB- heparins in the absence and presence of platelet_factor_4 -LRB- PF4 -RRB- .
19570917	0	plc-1	48,53	FOS-1	23,28	plc-1	FOS-1	181274(Tax:6239)	178987(Tax:6239)	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Caenorhabditis_elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation .
10455030	0	pleckstrin	108,118	pleckstrin	130,140	pleckstrin	pleckstrin	5341	5341	Gene	Gene	domain|amod|START_ENTITY domain|compound|END_ENTITY	Phosphotyrosine protein of molecular mass 30 kDa binds specifically to the positively charged region of the pleckstrin N-terminal pleckstrin homology domain .
10455030	0	pleckstrin	130,140	pleckstrin	108,118	pleckstrin	pleckstrin	5341	5341	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Phosphotyrosine protein of molecular mass 30 kDa binds specifically to the positively charged region of the pleckstrin N-terminal pleckstrin homology domain .
17008542	0	pleckstrin-2	15,27	PI3K	0,4	pleckstrin-2	PI3K	26499	5290	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization .
23184957	0	pleckstrin_homology_domain_leucine-rich_repeat_protein_phosphatase_2	63,131	Diacylglycerol_kinase	0,21	pleckstrin homology domain leucine-rich repeat protein phosphatase 2	Diacylglycerol kinase	23035	1607	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Diacylglycerol_kinase modulates Akt phosphorylation through pleckstrin_homology_domain_leucine-rich_repeat_protein_phosphatase_2 -LRB- PHLPP2 -RRB- .
19709076	0	plectin	53,60	BRCA2	0,5	plectin	BRCA2	5339	675	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization .
15681471	0	plectin	117,124	PLEC1	131,136	plectin	PLEC1	5339	5339	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Epidermolysis_bullosa simplex associated with pyloric_atresia is a novel clinical subtype caused by mutations in the plectin gene -LRB- PLEC1 -RRB- .
8894687	0	plectin	37,44	PLEC1	51,56	plectin	PLEC1	5339	5339	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Homozygous deletion mutations in the plectin gene -LRB- PLEC1 -RRB- in patients with epidermolysis_bullosa simplex associated with late-onset muscular_dystrophy .
18853744	0	plectin	15,22	cytokeratin_18	42,56	plectin	cytokeratin 18	5339	3875	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of plectin with modulation of cytokeratin_18 in human liver cells during staurosporine-induced apoptosis .
10578067	0	plectin	62,69	hemidesmosomal_500_kDa_protein	22,52	plectin	hemidesmosomal 500 kDa protein	786966(Tax:9913)	404126(Tax:9913)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the hemidesmosomal_500_kDa_protein -LRB- HD1 -RRB- as plectin .
24698102	0	pleiotrophin	23,35	CD19	60,64	pleiotrophin	CD19	5764	930	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Elevated expression of pleiotrophin in lymphocytic_leukemia CD19 + B cells .
1407714	0	pleiotrophin	22,34	HB-GAM	36,42	pleiotrophin	HB-GAM	5764	5764	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	The new growth factor pleiotrophin -LRB- HB-GAM -RRB- mRNA is selectively present in the meningothelial cells of human meningiomas .
16940294	0	pleiotrophin	33,45	Heparin_affin_regulatory_peptide	0,32	pleiotrophin	Heparin affin regulatory peptide	5764	5764	Gene	Gene	mediates|nsubj|START_ENTITY END_ENTITY|parataxis|mediates	Heparin_affin_regulatory_peptide / pleiotrophin mediates fibroblast_growth_factor_2 stimulatory effects on human prostate_cancer cells .
15985215	0	pleiotrophin	18,30	Midkine	0,7	pleiotrophin	Midkine	19242(Tax:10090)	17242(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Midkine regulates pleiotrophin organ-specific gene expression : evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family .
20369290	0	pleiotrophin	81,93	Neuroglycan_C	0,13	pleiotrophin	Neuroglycan C	24924(Tax:10116)	50568(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Neuroglycan_C , a brain-specific chondroitin sulfate proteoglycan , interacts with pleiotrophin , a heparin-binding growth factor .
10962555	1	pleiotrophin	104,116	PTN	65,68	pleiotrophin	PTN	5764	5764	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	PTN on the expression of growth factor pleiotrophin : a critical role of a retroviral Sp1-binding site .
11510908	0	pleiotrophin	46,58	PTN	60,63	pleiotrophin	PTN	19242(Tax:10090)	19242(Tax:10090)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of the angiogenetic factor pleiotrophin -LRB- PTN -RRB- in the growth plate of mice .
17251388	0	plekhh2	103,110	dendrin	80,87	plekhh2	dendrin	213556(Tax:10090)	13199(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	plekhh2	103,110	ehd3	89,93	plekhh2	ehd3	213556(Tax:10090)	57440(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	plekhh2	103,110	sh2d4a	95,101	plekhh2	sh2d4a	213556(Tax:10090)	72281(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
11868902	0	plenty_of_SH3s	45,59	DPOSH	61,66	plenty of SH3s	DPOSH	36990(Tax:7227)	36990(Tax:7227)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Neural-specific overexpression of drosophila plenty_of_SH3s -LRB- DPOSH -RRB- extends the longevity of adult flies .
18025083	0	plexin-B1	60,69	ErbB-2	0,6	plexin-B1	ErbB-2	5364	2064	Gene	Gene	signaling|nmod|START_ENTITY regulate|dobj|signaling regulate|nsubj|END_ENTITY	ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1 .
16055703	0	plexin-B1	14,23	PYK2	85,89	plexin-B1	PYK2	5364	2185	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|activation activation|nmod|END_ENTITY	Semaphorin_4D / plexin-B1 induces endothelial cell migration through the activation of PYK2 , Src , and the phosphatidylinositol_3-kinase-Akt pathway .
19388051	0	plexin-B1	108,117	Rac1	164,168	plexin-B1	Rac1	5364	5879	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Thermodynamic characterization of two homologous protein complexes : associations of the semaphorin receptor plexin-B1 RhoGTPase binding domain with Rnd1 and active Rac1 .
16055703	0	plexin-B1	14,23	Semaphorin_4D	0,13	plexin-B1	Semaphorin 4D	5364	10507	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Semaphorin_4D / plexin-B1 induces endothelial cell migration through the activation of PYK2 , Src , and the phosphatidylinositol_3-kinase-Akt pathway .
11292760	0	pneumococcal_surface_protein_A	52,82	lactoferrin	37,48	pneumococcal surface protein A	lactoferrin	653509	280846(Tax:9913)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of binding of human lactoferrin to pneumococcal_surface_protein_A .
25165882	0	poFUT1	16,22	LIF	0,3	poFUT1	LIF	23509	3976	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface .
19684413	0	podocalyxin	25,36	Cortactin	0,9	podocalyxin	Cortactin	192181(Tax:10116)	60465(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Cortactin interacts with podocalyxin and mediates morphological change of podocytes through its phosphorylation .
22412054	0	podocalyxin	36,47	ezrin	67,72	podocalyxin	ezrin	5420	7430	Gene	Gene	significance|nmod|START_ENTITY END_ENTITY|nsubj|significance	Clinicopathological significance of podocalyxin and phosphorylated ezrin in uterine endometrioid_adenocarcinoma .
26864383	0	podocalyxin-like	38,54	PODXL	56,61	podocalyxin-like	PODXL	192181(Tax:10116)	192181(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Discovery of a frameshift mutation in podocalyxin-like -LRB- PODXL -RRB- gene , coding for a neural_adhesion_molecule , as causal for autosomal-recessive_juvenile_Parkinsonism .
23975429	0	podoplanin	15,25	Ebp1	0,4	podoplanin	Ebp1	10630	5036	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Ebp1 activates podoplanin expression and contributes to oral tumorigenesis .
24944097	0	podoplanin	30,40	Prox1	55,60	podoplanin	Prox1	14726(Tax:10090)	19130(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional regulation of podoplanin expression by Prox1 in lymphatic endothelial cells .
20123990	0	podoplanin	12,22	SRC	0,3	podoplanin	SRC	14726(Tax:10090)	20779(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	SRC induces podoplanin expression to promote cell migration .
24932813	0	podoplanin	36,46	gp38	48,52	podoplanin	gp38	10630	10630	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinicopathological correlations of podoplanin -LRB- gp38 -RRB- expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk .
18158922	0	podoplanin	13,23	transforming_growth_factor-beta	27,58	podoplanin	transforming growth factor-beta	10630	7040	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of podoplanin by transforming_growth_factor-beta in human fibrosarcoma .
22561893	0	pol_b	21,26	DNA_polymerase_beta	0,19	pol b	DNA polymerase beta	5423	5423	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	DNA_polymerase_beta -LRB- pol_b -RRB- inhibitors : a comprehensive overview .
8771786	0	pollen_coat_protein	41,60	PCP	62,65	pollen coat protein	PCP	106300870	106300870	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Cloning of PCP1 , a member of a family of pollen_coat_protein -LRB- PCP -RRB- genes from Brassica_oleracea encoding novel cysteine-rich proteins involved in pollen-stigma interactions .
10383133	0	polo-like_kinase	27,43	PLK	45,48	polo-like kinase	PLK	5347	5347	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of polo-like_kinase -LRB- PLK -RRB- expression in squamous_cell_carcinomas of the head and neck .
9053852	0	polo-like_kinase	27,43	PLK	45,48	polo-like kinase	PLK	5347	5347	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of polo-like_kinase -LRB- PLK -RRB- expression in non-small_cell_lung_cancer .
9083047	0	polo-like_kinase	35,51	PLK	53,56	polo-like kinase	PLK	5347	5347	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Cell cycle regulation of the human polo-like_kinase -LRB- PLK -RRB- promoter .
24859762	0	polo-like_kinase_1	55,73	PLK1	75,79	polo-like kinase 1	PLK1	5347	5347	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Aromatic diacylhydrazine derivatives as a new class of polo-like_kinase_1 -LRB- PLK1 -RRB- inhibitors .
24160708	0	polo-like_kinase_1	16,34	Plk1	36,40	polo-like kinase 1	Plk1	5347	5347	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Developments of polo-like_kinase_1 -LRB- Plk1 -RRB- inhibitors as anti-cancer agents .
12447691	0	polo-like_kinase_1	54,72	cyclin_B1	115,124	polo-like kinase 1	cyclin B1	5347	891	Gene	Gene	activity|nmod|START_ENTITY phosphorylation|nmod|activity regulates|nsubj|phosphorylation regulates|dobj|localization localization|nmod|END_ENTITY	Cooperative phosphorylation including the activity of polo-like_kinase_1 regulates the subcellular localization of cyclin_B1 .
26754547	0	polo-like_kinase_1	10,28	p53	45,48	polo-like kinase 1	p53	5347	7157	Gene	Gene	START_ENTITY|appos|regulator regulator|nmod|END_ENTITY	Targeting polo-like_kinase_1 , a regulator of p53 , in the treatment of adrenocortical_carcinoma .
9315667	0	polycomb	50,58	hPc2	68,72	polycomb	hPc2	40358(Tax:7227)	8535	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Interference with the expression of a novel human polycomb protein , hPc2 , results in cellular transformation and apoptosis .
11158316	0	polycomb	10,18	iab-7	4,9	polycomb	iab-7	40358(Tax:7227)	47763(Tax:7227)	Gene	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity .
1349580	0	polycystic_kidney_disease	44,69	PKD1	76,80	polycystic kidney disease	PKD1	18763(Tax:10090)	18763(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human-mouse homologies in the region of the polycystic_kidney_disease gene -LRB- PKD1 -RRB- .
7896286	0	polycystic_kidney_disease	48,73	PKD1	80,84	polycystic kidney disease	PKD1	5310	5310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel cyclin gene -LRB- CCNF -RRB- in the region of the polycystic_kidney_disease gene -LRB- PKD1 -RRB- .
9521593	0	polycystic_kidney_disease	43,68	PKD1	37,41	polycystic kidney disease	PKD1	5310	5310	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Novel and recurrent mutations in the PKD1 -LRB- polycystic_kidney_disease -RRB- gene .
9716661	0	polycystic_kidney_disease	31,56	Pkd2	58,62	polycystic kidney disease	Pkd2	18764(Tax:10090)	18764(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the murine polycystic_kidney_disease -LRB- Pkd2 -RRB- gene .
14596619	0	polycystic_kidney_disease-1	66,93	PKD1	95,99	polycystic kidney disease-1	PKD1	5310	5310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transmembrane domain analysis of polycystin-1 , the product of the polycystic_kidney_disease-1 -LRB- PKD1 -RRB- gene : evidence for 11 membrane-spanning domains .
9773786	0	polycystic_kidney_disease-2	31,58	PKD2	60,64	polycystic kidney disease-2	PKD2	5311	5311	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A spectrum of mutations in the polycystic_kidney_disease-2 -LRB- PKD2 -RRB- gene from eight Canadian kindreds .
10923038	0	polycystic_kidney_disease_1	31,58	PKD1	60,64	polycystic kidney disease 1	PKD1	5310	5310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Screening the 3 ' region of the polycystic_kidney_disease_1 -LRB- PKD1 -RRB- gene in 41 Bulgarian and Australian kindreds reveals a prevalence of protein truncating mutations .
14695542	0	polycystic_kidney_disease_1	23,50	PKD1	52,56	polycystic kidney disease 1	PKD1	5310	5310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Large deletions in the polycystic_kidney_disease_1 -LRB- PKD1 -RRB- gene .
7835880	0	polycystic_kidney_disease_1	31,58	PKD1	60,64	polycystic kidney disease 1	PKD1	5310	5310	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	A large duplicated area in the polycystic_kidney_disease_1 -LRB- PKD1 -RRB- region of chromosome 16 is prone to rearrangement .
11438989	0	polycystic_kidney_disease_2	23,50	PKD2	52,56	polycystic kidney disease 2	PKD2	5311	5311	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations of the human polycystic_kidney_disease_2 -LRB- PKD2 -RRB- gene .
23315160	0	polycystic_kidney_disease_2	54,81	PKD2	83,87	polycystic kidney disease 2	PKD2	641309(Tax:9823)	641309(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Construction of a transgenic pig model overexpressing polycystic_kidney_disease_2 -LRB- PKD2 -RRB- gene .
9573526	0	polycystic_kidney_disease_2	69,96	PKD2	98,102	polycystic kidney disease 2	PKD2	5311	5311	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel frameshift mutation induced by an adenosine insertion in the polycystic_kidney_disease_2 -LRB- PKD2 -RRB- gene .
10532593	0	polycystin-1	24,36	PKD1	4,8	polycystin-1	PKD1	5310	5310	Gene	Gene	product|dep|START_ENTITY product|compound|END_ENTITY	The PKD1 gene product , `` polycystin-1 , '' is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal_epithelia .
16537653	0	polycystin-1	48,60	Polycystin-2	0,12	polycystin-1	Polycystin-2	5310	5311	Gene	Gene	motif|amod|START_ENTITY cilia|nmod|motif traffics|nmod|cilia traffics|nsubj|END_ENTITY	Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif .
23848298	0	polycystin-1	48,60	Polycystin-2	0,12	polycystin-1	Polycystin-2	5310	5311	Gene	Gene	change|nmod|START_ENTITY induces|dobj|change induces|nsubj|END_ENTITY	Polycystin-2 induces a conformational change in polycystin-1 .
17102641	0	polycystin-1	22,34	mTOR	14,18	polycystin-1	mTOR	5310	21977(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of mTOR by polycystin-1 : is polycystic_kidney_disease a case of futile repair ?
11786542	0	polycystin-1	41,53	polycystin-2	72,84	polycystin-1	polycystin-2	5310	5311	Gene	Gene	G-proteins|nmod|START_ENTITY activation|nmod|G-proteins antagonized|nsubjpass|activation antagonized|advcl|END_ENTITY	Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2 .
19491093	0	polycystin-2	49,61	Polycystin-1	0,12	polycystin-2	Polycystin-1	5311	5310	Gene	Gene	expression|amod|START_ENTITY modulated|nmod|expression modulated|nsubjpass|C-terminal C-terminal|compound|END_ENTITY	Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression .
25574838	0	polycystin-2	33,45	Polycystin-1	0,12	polycystin-2	Polycystin-1	18764(Tax:10090)	18763(Tax:10090)	Gene	Gene	requires|xcomp|START_ENTITY requires|nsubj|maturation maturation|amod|END_ENTITY	Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner .
11786542	0	polycystin-2	72,84	polycystin-1	41,53	polycystin-2	polycystin-1	5311	5310	Gene	Gene	antagonized|advcl|START_ENTITY antagonized|nsubjpass|activation activation|nmod|G-proteins G-proteins|nmod|END_ENTITY	Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2 .
20215348	0	polycystin_2	45,57	bicaudal_C	24,34	polycystin 2	bicaudal C	18764(Tax:10090)	83675(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The RNA-binding protein bicaudal_C regulates polycystin_2 in the kidney by antagonizing miR-17 activity .
15355434	0	polyglutamine-binding_protein_1	67,98	PQBP1	105,110	polyglutamine-binding protein 1	PQBP1	10084	10084	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotype-phenotype studies in three families with mutations in the polyglutamine-binding_protein_1 gene -LRB- PQBP1 -RRB- .
12138179	0	polymerase	37,47	p68	12,15	polymerase	p68	5422	10714	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Role of the p68 subunit of human DNA polymerase alpha-primase in simian_virus_40 DNA replication .
20564315	0	polymerase_1_and_transcript_release_factor	35,77	PTRF	79,83	polymerase 1 and transcript release factor	PTRF	284119	284119	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Changes in caveolae , caveolin , and polymerase_1_and_transcript_release_factor -LRB- PTRF -RRB- expression in prostate_cancer progression .
25131834	0	polymerase_delta_1	42,60	POLD1	62,67	polymerase delta 1	POLD1	5424	5424	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel mutation in the polymerase_delta_1 -LRB- POLD1 -RRB- gene in a lipodystrophic patient affected by mandibular_hypoplasia , deafness , progeroid_features _ -LRB- MDPL -RRB- _ syndrome .
14688158	0	polymerase_gamma	47,63	POLG	70,74	polymerase gamma	POLG	5428	5428	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	Frequent polymorphism of the mitochondrial DNA polymerase_gamma gene -LRB- POLG -RRB- in patients with normal spermiograms and unexplained subfertility .
18316366	0	polymerase_gamma	35,51	POLG	53,57	polymerase gamma	POLG	5428	5428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	CAG repeat length variation in the polymerase_gamma -LRB- POLG -RRB- gene : effect on semen quality .
17420318	0	polymerase_gamma-1	37,55	POLG1	57,62	polymerase gamma-1	POLG1	5428	5428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation of the linker region of the polymerase_gamma-1 -LRB- POLG1 -RRB- gene associated with progressive external ophthalmoplegia and Parkinsonism .
15972671	0	polymeric_Ig_receptor	18,39	TLRs_3_and_4	61,73	polymeric Ig receptor	TLRs 3 and 4	5284	7098;7099	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Regulation of the polymeric_Ig_receptor by signaling through TLRs_3_and_4 : linking innate and adaptive immune responses .
26239418	0	polymeric_immunoglobulin_receptor	62,95	Secretory_leukocyte_protease_inhibitor	0,38	polymeric immunoglobulin receptor	Secretory leukocyte protease inhibitor	5284	6590	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Secretory_leukocyte_protease_inhibitor inhibits expression of polymeric_immunoglobulin_receptor via the NF-kB signaling pathway .
14678201	0	polymeric_immunoglobulin_receptor	77,110	interleukin-4	37,50	polymeric immunoglobulin receptor	interleukin-4	397315(Tax:9823)	3565	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Nuclear_factor-kappaB contributes to interleukin-4 - and interferon-dependent polymeric_immunoglobulin_receptor expression in human intestinal epithelial cells .
26910773	0	polymeric_immunoglobulin_receptor	22,55	pIgR	57,61	polymeric immunoglobulin receptor	pIgR	5284	5284	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Reduced expression of polymeric_immunoglobulin_receptor -LRB- pIgR -RRB- in nasopharyngeal_carcinoma and its correlation with prognosis .
1372533	0	polymorphic_epithelial_mucin	38,66	MUC1	68,72	polymorphic epithelial mucin	MUC1	4582	4582	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Tissue-specific expression of a human polymorphic_epithelial_mucin -LRB- MUC1 -RRB- in transgenic_mice .
19410332	0	polyoma_enhancer_activator_3	63,91	FGF-10	52,58	polyoma enhancer activator 3	FGF-10	18612(Tax:10090)	14165(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Negative regulation of fibroblast_growth_factor_10 -LRB- FGF-10 -RRB- by polyoma_enhancer_activator_3 -LRB- PEA3 -RRB- .
19410332	0	polyoma_enhancer_activator_3	63,91	fibroblast_growth_factor_10	23,50	polyoma enhancer activator 3	fibroblast growth factor 10	18612(Tax:10090)	14165(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of fibroblast_growth_factor_10 -LRB- FGF-10 -RRB- by polyoma_enhancer_activator_3 -LRB- PEA3 -RRB- .
24619076	0	polypeptide_N-acetylgalactosaminyl_transferase-5	25,73	GalNAc-T5	75,84	polypeptide N-acetylgalactosaminyl transferase-5	GalNAc-T5	11227	11227	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Clinical significance of polypeptide_N-acetylgalactosaminyl_transferase-5 -LRB- GalNAc-T5 -RRB- expression in patients with gastric_cancer .
1658675	0	polypeptide_YY	16,30	PYY	32,35	polypeptide YY	PYY	287730(Tax:10116)	287730(Tax:10116)	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Acute action of polypeptide_YY -LRB- PYY -RRB- on rat adrenocortical cells : in vivo versus in vitro effects .
17426955	0	polyphenol_oxidase	21,39	PPO	41,44	polyphenol oxidase	PPO	543157(Tax:4565)	543157(Tax:4565)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Allelic variation of polyphenol_oxidase -LRB- PPO -RRB- genes located on chromosomes 2A and 2D and development of functional markers for the PPO genes in common_wheat .
23461298	0	polyphenol_oxidase	52,70	PPO	72,75	polyphenol oxidase	PPO	5498	5498	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Polyphenolic composition , antioxidant activity , and polyphenol_oxidase -LRB- PPO -RRB- activity of quince -LRB- Cydonia oblonga Miller -RRB- varieties .
25882427	0	polyphenol_oxidase	24,42	PPO	44,47	polyphenol oxidase	PPO	5498	5498	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Real-time evaluation of polyphenol_oxidase -LRB- PPO -RRB- activity in lychee pericarp based on weighted combination of spectral data and image features as determined by fuzzy neural network .
7507279	0	polyprotein	112,123	polyprotein	51,62	polyprotein	polyprotein	956513(Tax:11002)	956513(Tax:11002)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of infectious_pancreatic_necrosis_virus polyprotein and VP1 in insect cells and the detection of the polyprotein in purified virus .
7507279	0	polyprotein	51,62	polyprotein	112,123	polyprotein	polyprotein	956513(Tax:11002)	956513(Tax:11002)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of infectious_pancreatic_necrosis_virus polyprotein and VP1 in insect cells and the detection of the polyprotein in purified virus .
8649976	0	polypyrimidine_tract_binding	4,32	PTB	34,37	polypyrimidine tract binding	PTB	5725	5725	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	The polypyrimidine_tract_binding -LRB- PTB -RRB- protein interacts with single-stranded DNA in a sequence-specific manner .
11804786	0	polypyrimidine_tract_binding_protein	31,67	PTB	69,72	polypyrimidine tract binding protein	PTB	48571(Tax:7227)	48571(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Lineage-specific expression of polypyrimidine_tract_binding_protein -LRB- PTB -RRB- in Drosophila embryos .
24323452	0	polysaccharide-K	14,30	IL-1b	39,44	polysaccharide-K	IL-1b	9344	3553	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|END_ENTITY	Protein-bound polysaccharide-K induces IL-1b via TLR2 and NLRP3 inflammasome activation .
24615737	0	pon1	67,71	paraoxonase_1	52,65	pon1	paraoxonase 1	84024(Tax:10116)	84024(Tax:10116)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	The effect of in vitro dieldrin exposure on the rat paraoxonase_1 -LRB- pon1 -RRB- promoter .
9358038	0	ponA	16,20	penicillin-binding_protein_1A	54,83	ponA	penicillin-binding protein 1A	881163(Tax:208964)	881163(Tax:208964)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Sequence of the ponA gene and characterization of the penicillin-binding_protein_1A of Pseudomonas_aeruginosa_PAO1 .
22290329	0	popdc2	32,38	Popeye_domain_containing_2	4,30	popdc2	Popeye domain containing 2	793666(Tax:7955)	793666(Tax:7955)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The Popeye_domain_containing_2 -LRB- popdc2 -RRB- gene in zebrafish is required for heart and skeletal muscle development .
20480242	0	porcine_adipose_triglyceride_lipase	55,90	PNPLA2	92,98	porcine adipose triglyceride lipase	PNPLA2	57104	57104	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular characterization and association analysis of porcine_adipose_triglyceride_lipase -LRB- PNPLA2 -RRB- gene .
1691263	0	pore-forming_protein	27,47	CD8	90,93	pore-forming protein	CD8	5551	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Interleukin_2 induction of pore-forming_protein gene expression in human peripheral blood CD8 + T cells .
1691263	0	pore-forming_protein	27,47	Interleukin_2	0,13	pore-forming protein	Interleukin 2	5551	3558	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Interleukin_2 induction of pore-forming_protein gene expression in human peripheral blood CD8 + T cells .
8579600	0	porin	18,23	MAP2	46,50	porin	MAP2	7416	4133	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|site site|nmod|END_ENTITY	Identification of porin as a binding site for MAP2 .
7615541	0	porphobilinogen_deaminase	65,90	DNase-I	23,30	porphobilinogen deaminase	DNase-I	15288(Tax:10090)	13419(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY sites|nmod|gene sites|amod|END_ENTITY	Functional analysis of DNase-I hypersensitive sites at the mouse porphobilinogen_deaminase gene locus .
2542327	0	porphobilinogen_deaminase	98,123	PBG-D	125,130	porphobilinogen deaminase	PBG-D	3145	3145	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulated expression of the overlapping ubiquitous and erythroid transcription units of the human porphobilinogen_deaminase -LRB- PBG-D -RRB- gene introduced into non-erythroid and erythroid cells .
21193408	0	positive_cofactor_4	24,43	LHR	96,99	positive cofactor 4	LHR	10923	3973	Gene	Gene	START_ENTITY|nmod|gene gene|appos|END_ENTITY	Coactivator function of positive_cofactor_4 -LRB- PC4 -RRB- in Sp1-directed luteinizing_hormone_receptor -LRB- LHR -RRB- gene transcription .
21193408	0	positive_cofactor_4	24,43	luteinizing_hormone_receptor	66,94	positive cofactor 4	luteinizing hormone receptor	10923	3973	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Coactivator function of positive_cofactor_4 -LRB- PC4 -RRB- in Sp1-directed luteinizing_hormone_receptor -LRB- LHR -RRB- gene transcription .
23048031	0	positive_regulatory_domain_4	21,49	protein_arginine_methyltransferase_5	67,103	positive regulatory domain 4	protein arginine methyltransferase 5	11108	10419	Gene	Gene	recruits|nsubj|START_ENTITY recruits|dobj|END_ENTITY	Transcription factor positive_regulatory_domain_4 -LRB- PRDM4 -RRB- recruits protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- to mediate histone arginine methylation and control neural stem cell proliferation and differentiation .
19828640	0	positive_regulatory_domain_I-binding_factor_1	15,60	Blimp-1	61,68	positive regulatory domain I-binding factor 1	Blimp-1	639	639	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	PU .1 regulates positive_regulatory_domain_I-binding_factor_1 / Blimp-1 transcription in lymphoma cells .
26969072	0	post-synaptic_density_95	73,97	Akt	151,154	post-synaptic density 95	Akt	1742	207	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Lambda-cyhalothrin disrupts the up-regulation effect of 17b-estradiol on post-synaptic_density_95 protein expression via estrogen_receptor_a-dependent Akt pathway .
18172091	0	posterior_polymorphous_corneal_dystrophy_3	16,58	TCF8	65,69	posterior polymorphous corneal dystrophy 3	TCF8	6935	6935	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the posterior_polymorphous_corneal_dystrophy_3 gene , TCF8 , in late-onset Fuchs_endothelial_corneal_dystrophy .
21965656	0	postsynaptic_density-95	101,124	PSD-95	126,132	postsynaptic density-95	PSD-95	1742	1742	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Phosphorylation of a PDZ domain extension modulates binding affinity and interdomain interactions in postsynaptic_density-95 -LRB- PSD-95 -RRB- protein , a membrane-associated guanylate kinase -LRB- MAGUK -RRB- .
10844022	0	postsynaptic_density-95	19,42	guanylate_kinase_domain-associated_protein	43,85	postsynaptic density-95	guanylate kinase domain-associated protein	116681(Tax:10116)	65040(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|complex complex|amod|END_ENTITY	Interaction of the postsynaptic_density-95 / guanylate_kinase_domain-associated_protein complex with a light chain of myosin-V and dynein .
12122038	0	postsynaptic_density-95	23,46	stargazin	101,110	postsynaptic density-95	stargazin	1742	10369	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Phosphorylation of the postsynaptic_density-95 -LRB- PSD-95 -RRB- / discs large/zona _ occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors .
24980667	0	potassium_channel_modulatory_factor_1	59,96	MicroRNA-210	0,12	potassium channel modulatory factor 1	MicroRNA-210	56888	406992	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	MicroRNA-210 contributes to preeclampsia by downregulating potassium_channel_modulatory_factor_1 .
7623846	0	pp120	82,87	FER	32,35	pp120	FER	3192	2241	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors .
8380406	0	pp120/ecto-ATPase	0,17	insulin_receptor	50,66	pp120/ecto-ATPase	insulin receptor	81613(Tax:10116)	24954(Tax:10116)	Gene	Gene	START_ENTITY|appos|substrate substrate|nmod|kinase kinase|compound|END_ENTITY	pp120/ecto-ATPase , an endogenous substrate of the insulin_receptor tyrosine kinase , is expressed as two variably spliced isoforms .
21029396	0	pp125FAK	38,46	Plexin_B1	0,9	pp125FAK	Plexin B1	5747	5364	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Plexin_B1 inhibits integrin-dependent pp125FAK and Rho activity in melanoma .
21152064	0	pp32	0,4	ANP32A	6,12	pp32	ANP32A	8125	8125	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	pp32 -LRB- ANP32A -RRB- expression inhibits pancreatic_cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs .
11137562	0	pp52	65,69	LSP1	71,75	pp52	LSP1	4046	4046	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Aberrant expression and localization of the cytoskeleton-binding pp52 -LRB- LSP1 -RRB- protein in hairy_cell_leukemia .
11368895	0	pp52	37,41	LSP1	43,47	pp52	LSP1	4046	4046	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Leukocyte-specific expression of the pp52 -LRB- LSP1 -RRB- promoter is controlled by the cis-acting pp52 silencer and anti-silencer elements .
1372401	0	pp60c-src	106,115	pp60c-src	95,104	pp60c-src	pp60c-src	20779(Tax:10090)	20779(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src , pp60c-src + .
1372401	0	pp60c-src	95,104	pp60c-src	106,115	pp60c-src	pp60c-src	20779(Tax:10090)	20779(Tax:10090)	Gene	Gene	+|amod|START_ENTITY +|amod|END_ENTITY	Tyrosine phosphorylation of a 120,000 dalton membrane-associated protein by the neural form of pp60c-src , pp60c-src + .
18853954	0	pp65	49,53	CD8	54,57	pp65	CD8	18826(Tax:10090)	925	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Polyfunctional cytomegalovirus-specific CD4 + and pp65 CD8 + T cells protect against high-level replication after liver transplantation .
12220661	0	ppMCH	27,32	MCHR1	53,58	ppMCH	MCHR1	5367	2847	Gene	Gene	START_ENTITY|dobj|receptor receptor|compound|END_ENTITY	Human immune cells express ppMCH mRNA and functional MCHR1 receptor .
8906359	0	pr22	55,59	Op18	61,65	pr22	Op18	3925	3925	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional and post-transcriptional regulation of pr22 -LRB- Op18 -RRB- with proliferation control .
20836130	0	prdm1a	0,6	sox10	17,22	prdm1a	sox10	323473(Tax:7955)	140616(Tax:7955)	Gene	Gene	Regulates|nsubj|START_ENTITY Regulates|dobj|END_ENTITY	prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard_sensory_neurons .
10194127	0	pre-B	49,54	tumor_necrosis_factor-alpha	73,100	pre-B	tumor necrosis factor-alpha	10113	7124	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Suppression of growth and dissemination in human pre-B leukemia cells by tumor_necrosis_factor-alpha in scid mice .
24053186	0	pre-B-cell_colony-enhancing_factor	26,60	NAMPT	61,66	pre-B-cell colony-enhancing factor	NAMPT	10135	10135	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Mechanical stress induces pre-B-cell_colony-enhancing_factor / NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium .
22487217	0	pre-B-cell_colony-enhancing_factor	25,59	PBEF	61,65	pre-B-cell colony-enhancing factor	PBEF	10135	10135	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Pleiotropic functions of pre-B-cell_colony-enhancing_factor -LRB- PBEF -RRB- revealed by transcriptomics of human pulmonary microvascular endothelial cells treated with PBEFsiRNA .
10587355	0	pre-T_cell_receptor	62,81	Extracellular_signal-regulated_kinase	0,37	pre-T cell receptor	Extracellular signal-regulated kinase	6962	5594	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Extracellular_signal-regulated_kinase -LRB- ERK -RRB- activation by the pre-T_cell_receptor in developing thymocytes in vivo .
24718257	0	pre-mRNA_processing_factor_19	109,138	Small_kinetochore_associated_protein	0,36	pre-mRNA processing factor 19	Small kinetochore associated protein	27339	90417	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Small_kinetochore_associated_protein -LRB- SKAP -RRB- promotes UV-induced cell apoptosis through negatively regulating pre-mRNA_processing_factor_19 -LRB- Prp19 -RRB- .
3025666	0	prealbumin	37,47	transthyretin	49,62	prealbumin	transthyretin	22139(Tax:10090)	22139(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional control of the mouse prealbumin -LRB- transthyretin -RRB- gene : both promoter sequences and a distinct enhancer are cell specific .
10964938	0	precerebellin	29,42	Cbln3	0,5	precerebellin	Cbln3	12404(Tax:10090)	56410(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Cbln3 , a novel member of the precerebellin family that binds specifically to Cbln1 .
25660740	0	pregnancy-associated_glycoprotein	24,57	PAG	59,62	pregnancy-associated glycoprotein	PAG	517463(Tax:9913)	517463(Tax:9913)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Factors associated with pregnancy-associated_glycoprotein -LRB- PAG -RRB- levels in plasma and milk of Holstein cows during early pregnancy and their effect on the accuracy of pregnancy diagnosis .
17010415	0	pregnancy-associated_glycoprotein-1	7,42	PAG-1	44,49	pregnancy-associated glycoprotein-1	PAG-1	281964(Tax:9913)	281964(Tax:9913)	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Plasma pregnancy-associated_glycoprotein-1 -LRB- PAG-1 -RRB- concentrations during gestation in Neospora-infected dairy cows .
15541345	0	pregnancy-associated_plasma_protein-A	23,60	IGFBP-4	0,7	pregnancy-associated plasma protein-A	IGFBP-4	18491(Tax:10090)	16010(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	IGFBP-4 degradation by pregnancy-associated_plasma_protein-A in MC3T3 osteoblasts .
2420292	0	pregnancy-associated_plasma_protein-A	11,48	PAPP-A	50,56	pregnancy-associated plasma protein-A	PAPP-A	5069	5069	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- to placental subfractions .
2420432	0	pregnancy-associated_plasma_protein-A	41,78	PAPP-A	80,86	pregnancy-associated plasma protein-A	PAPP-A	5069	5069	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Circulating and tissue concentrations of pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- in tubal ectopic gestation .
2438194	0	pregnancy-associated_plasma_protein-A	14,51	PAPP-A	53,59	pregnancy-associated plasma protein-A	PAPP-A	5069	5069	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of pregnancy-associated_plasma_protein-A -LRB- PAPP-A -RRB- by cultured tumour granulosa cells .
24188108	0	pregnancy-associated_plasma_protein-A	25,62	Placental_growth_factor	0,23	pregnancy-associated plasma protein-A	Placental growth factor	5069	5228	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	Placental_growth_factor , pregnancy-associated_plasma_protein-A , soluble receptor for advanced glycation end products , extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high_mobility_group_box_1 levels in patients with acute_kidney_injury : a cross sectional study .
23401929	0	pregnancy-associated_plasma_protein_A	16,53	PAPP-A	55,61	pregnancy-associated plasma protein A	PAPP-A	5069	5069	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of pregnancy-associated_plasma_protein_A -LRB- PAPP-A -RRB- concentration determination in the assessment of final outcome of pregnancy .
6191321	0	pregnancy-associated_plasma_protein_A	17,54	PAPP-A	56,62	pregnancy-associated plasma protein A	PAPP-A	5069	5069	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Concentration of pregnancy-associated_plasma_protein_A -LRB- PAPP-A -RRB- in patients with pre-eclamptic_toxaemia .
6209702	0	pregnancy-associated_plasma_protein_A	36,73	PAPP-A	75,81	pregnancy-associated plasma protein A	PAPP-A	5069	5069	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of pregnancy-associated_plasma_protein_A -LRB- PAPP-A -RRB- in placentae from normal and pre-eclamptic pregnancies .
20197085	0	pregnancy-associated_plasma_protein_A	67,104	PappA	106,111	pregnancy-associated plasma protein A	PappA	18491(Tax:10090)	18491(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated_plasma_protein_A -LRB- PappA -RRB- gene .
21496272	0	pregnancy-associated_plasma_protein_A2	14,52	PAPPA2	54,60	pregnancy-associated plasma protein A2	PAPPA2	60676	60676	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of pregnancy-associated_plasma_protein_A2 -LRB- PAPPA2 -RRB- in a human placental trophoblast cell line -LRB- BeWo -RRB- .
3263130	0	pregnancy-specific_beta_1-glycoprotein	39,77	CEA	101,104	pregnancy-specific beta 1-glycoprotein	CEA	5673	5670	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Exon-intron organization of a gene for pregnancy-specific_beta_1-glycoprotein , a subfamily member of CEA family : implications for its characteristic repetitive domains and C-terminal sequences .
6416936	0	pregnancy-specific_beta_1-glycoprotein	16,54	SP1	56,59	pregnancy-specific beta 1-glycoprotein	SP1	653492	653492	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of pregnancy-specific_beta_1-glycoprotein -LRB- SP1 -RRB- in women with pregnancies at risk .
15647114	0	pregnancy-specific_glycoprotein	37,68	Psg	70,73	pregnancy-specific glycoprotein	Psg	26436(Tax:10090)	26436(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and evolution of the mouse pregnancy-specific_glycoprotein -LRB- Psg -RRB- gene locus .
17475324	0	pregnancy-specific_glycoprotein_5	23,56	RXRalpha	0,8	pregnancy-specific glycoprotein 5	RXRalpha	5673	6256	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	RXRalpha regulates the pregnancy-specific_glycoprotein_5 gene transcription through a functional retinoic_acid responsive element .
7684253	0	pregnancy_associated_plasma_protein_A	29,66	PAPP-A	68,74	pregnancy associated plasma protein A	PAPP-A	5069	5069	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Low maternal serum levels of pregnancy_associated_plasma_protein_A -LRB- PAPP-A -RRB- in the first trimester in association with abnormal fetal karyotype .
2306242	0	pregnancy_specific_beta_1_glycoprotein	20,58	PSG	60,63	pregnancy specific beta 1 glycoprotein	PSG	5673	5673	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Expression of human pregnancy_specific_beta_1_glycoprotein -LRB- PSG -RRB- genes during placental development .
22927137	0	pregnane-X-receptor	85,104	P-glycoprotein	55,69	pregnane-X-receptor	P-glycoprotein	84385(Tax:10116)	287115(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats .
18381611	0	pregnane-X_receptor	42,61	NR1I2	68,73	pregnane-X receptor	NR1I2	8856	8856	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of associations between the pregnane-X_receptor gene -LRB- NR1I2 -RRB- and Crohn 's _ disease in Canadian children using a gene-wide haplotype-based approach .
11706036	0	pregnane_X_receptor	89,108	ABCC2	57,62	pregnane X receptor	ABCC2	84385(Tax:10116)	25303(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of multidrug_resistance-associated_protein_2 -LRB- ABCC2 -RRB- by the nuclear receptors pregnane_X_receptor , farnesoid_X-activated_receptor , and constitutive_androstane_receptor .
11005856	0	pregnane_X_receptor	88,107	CXR	0,3	pregnane X receptor	CXR	8856	395439(Tax:9031)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	CXR , a chicken xenobiotic-sensing orphan nuclear receptor , is related to both mammalian pregnane_X_receptor -LRB- PXR -RRB- and constitutive_androstane_receptor -LRB- CAR -RRB- .
25424564	0	pregnane_X_receptor	8,27	CYP2	96,100	pregnane X receptor	CYP2	565875(Tax:7955)	415182(Tax:7955)	Gene	Gene	receptor|compound|START_ENTITY Role|nmod|receptor Role|nmod|END_ENTITY	Role of pregnane_X_receptor and aryl_hydrocarbon receptor in transcriptional regulation of pxr , CYP2 , and CYP3 genes in developing zebrafish .
11502872	0	pregnane_X_receptor	51,70	CYP2B6	24,30	pregnane X receptor	CYP2B6	8856	1555	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the human CYP2B6 gene by the nuclear pregnane_X_receptor .
11950789	0	pregnane_X_receptor	76,95	CYP3A	13,18	pregnane X receptor	CYP3A	18171(Tax:10090)	13112(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY Induction|dep|involvement Induction|nmod|expression expression|nummod|END_ENTITY	Induction of CYP3A expression by dehydroepiandrosterone : involvement of the pregnane_X_receptor .
14709622	0	pregnane_X_receptor	109,128	CYP3A	0,5	pregnane X receptor	CYP3A	18171(Tax:10090)	170509(Tax:10116)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|induction induction|nummod|END_ENTITY	CYP3A induction by liver_x_receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane_X_receptor .
15075359	0	pregnane_X_receptor	97,116	CYP3A	63,68	pregnane X receptor	CYP3A	8856	1576	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|nummod|END_ENTITY	Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane_X_receptor .
16547076	0	pregnane_X_receptor	69,88	CYP3A	37,42	pregnane X receptor	CYP3A	8856	1576	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|END_ENTITY	The mycoestrogen zearalenone induces CYP3A through activation of the pregnane_X_receptor .
20082578	0	pregnane_X_receptor	75,94	CYP3A	157,162	pregnane X receptor	CYP3A	8856	1576	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene region|acl|associated associated|nmod|variability variability|nmod|metabolism metabolism|appos|END_ENTITY	Identification of polymorphisms in the 3 ' - untranslated region of the human pregnane_X_receptor -LRB- PXR -RRB- gene associated with variability in cytochrome_P450_3A -LRB- CYP3A -RRB- metabolism .
21402137	0	pregnane_X_receptor	100,119	CYP3A	77,82	pregnane X receptor	CYP3A	84385(Tax:10116)	170509(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY inhibition|nmod|activation interacts|nmod|inhibition interacts|nmod|drugs drugs|nmod|END_ENTITY	3,4-methylenedioxymethamphetamine -LRB- MDMA -RRB- interacts with therapeutic drugs on CYP3A by inhibition of pregnane_X_receptor -LRB- PXR -RRB- activation and catalytic enzyme inhibition .
24853400	0	pregnane_X_receptor	74,93	CYP3A	14,19	pregnane X receptor	CYP3A	18171(Tax:10090)	13112(Tax:10090)	Gene	Gene	ligands|compound|START_ENTITY mediated|nmod|ligands mediated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane_X_receptor ligands formed by enhanced cholesterol metabolism .
10570062	0	pregnane_X_receptor	17,36	CYP3A4	80,86	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	The orphan human pregnane_X_receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module .
10908304	0	pregnane_X_receptor	149,168	CYP3A4	129,135	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	activators|compound|START_ENTITY induces|nmod|activators induces|dobj|expression expression|dep|increase increase|nmod|induction induction|compound|END_ENTITY	Dexamethasone induces pregnane_X_receptor and retinoid_X_receptor-alpha expression in human hepatocytes : synergistic increase of CYP3A4 induction by pregnane_X_receptor activators .
10908304	0	pregnane_X_receptor	22,41	CYP3A4	129,135	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	expression|compound|START_ENTITY expression|dep|increase increase|nmod|induction induction|compound|END_ENTITY	Dexamethasone induces pregnane_X_receptor and retinoid_X_receptor-alpha expression in human hepatocytes : synergistic increase of CYP3A4 induction by pregnane_X_receptor activators .
11602521	0	pregnane_X_receptor	28,47	CYP3A4	93,99	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	variants|nmod|START_ENTITY variants|nmod|activity activity|nmod|END_ENTITY	Natural protein variants of pregnane_X_receptor with altered transactivation activity toward CYP3A4 .
12065438	0	pregnane_X_receptor	49,68	CYP3A4	0,6	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	assay|compound|START_ENTITY correlation|nmod|assay induction|dep|correlation induction|nummod|END_ENTITY	CYP3A4 induction by drugs : correlation between a pregnane_X_receptor reporter gene assay and CYP3A4 expression in human hepatocytes .
12167569	0	pregnane_X_receptor	119,138	CYP3A4	37,43	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	element|compound|START_ENTITY interaction|nmod|element decreased|parataxis|interaction decreased|nsubjpass|induction induction|nmod|END_ENTITY	Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein : DNA interaction distinct from the pregnane_X_receptor response element .
16455805	0	pregnane_X_receptor	40,59	CYP3A4	24,30	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	talk|compound|START_ENTITY requires|dobj|talk requires|nsubj|induction induction|nmod|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
17293382	0	pregnane_X_receptor	20,39	CYP3A4	88,94	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	involvement|compound|START_ENTITY Assessment|nmod|involvement Assessment|nmod|gene gene|compound|END_ENTITY	Assessment of human pregnane_X_receptor involvement in pesticide-mediated activation of CYP3A4 gene .
17764444	0	pregnane_X_receptor	113,132	CYP3A4	36,42	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	responding|nmod|START_ENTITY co-ordinate|advcl|responding co-ordinate|nsubj|enhancers enhancers|nmod|gene gene|compound|END_ENTITY	The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane_X_receptor but differentially to hepatocyte_nuclear_factor-4alpha .
19077665	0	pregnane_X_receptor	81,100	CYP3A4	14,20	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	disruption|nmod|START_ENTITY mediated|nmod|disruption mediated|nsubjpass|Inhibition Inhibition|nmod|expression expression|nummod|END_ENTITY	Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane_X_receptor , steroid receptor coactivator-1 , and hepatocyte_nuclear_factor_4alpha interaction .
19297428	0	pregnane_X_receptor	77,96	CYP3A4	6,12	pregnane X receptor	CYP3A4	18171(Tax:10090)	1576	Gene	Gene	equol|nmod|START_ENTITY regulated|nmod|equol regulated|nsubjpass|END_ENTITY	Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane_X_receptor in a species-specific manner .
21920351	0	pregnane_X_receptor	21,40	CYP3A4	76,82	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	START_ENTITY|dep|transactivation transactivation|nmod|gene gene|compound|END_ENTITY	Metformin suppresses pregnane_X_receptor -LRB- PXR -RRB- - regulated transactivation of CYP3A4 gene .
22076448	0	pregnane_X_receptor	82,101	CYP3A4	42,48	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	activate|nmod|START_ENTITY activate|dobj|transcription transcription|nummod|END_ENTITY	Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane_X_receptor .
22363234	0	pregnane_X_receptor	131,150	CYP3A4	61,67	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	expression|nmod|START_ENTITY cytochrome_P450_3A4|dep|expression cytochrome_P450_3A4|appos|END_ENTITY	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
22648626	0	pregnane_X_receptor	40,59	CYP3A4	18,24	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Capsaicin induces CYP3A4 expression via pregnane_X_receptor and CCAAT/enhancer-binding _ protein_b activation .
23330538	0	pregnane_X_receptor	14,33	CYP3A4	49,55	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|dep|interactions interactions|compound|END_ENTITY	Evaluation of pregnane_X_receptor -LRB- PXR -RRB- - mediated CYP3A4 drug-drug interactions in drug development .
23928187	0	pregnane_X_receptor	109,128	CYP3A4	27,33	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	binding|xcomp|START_ENTITY binding|nsubj|regulation regulation|nmod|activity activity|compound|END_ENTITY	Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane_X_receptor .
23977680	0	pregnane_X_receptor	73,92	CYP3A4	113,119	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	activity|compound|START_ENTITY activity|nmod|element element|compound|END_ENTITY	A nonradioactive electrophoretic mobility shift assay for measurement of pregnane_X_receptor binding activity to CYP3A4 response element .
26782648	0	pregnane_X_receptor	15,34	CYP3A4	65,71	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	SUMOylation|nmod|START_ENTITY suppresses|nsubj|SUMOylation suppresses|dobj|END_ENTITY	SUMOylation of pregnane_X_receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells .
26987505	0	pregnane_X_receptor	93,112	CYP3A4	49,55	pregnane X receptor	CYP3A4	8856	1576	Gene	Gene	activates|nmod|START_ENTITY activates|dobj|transcription transcription|nummod|END_ENTITY	Indirubin , a component of Ban-Lan-Gen , activates CYP3A4 gene transcription through the human pregnane_X_receptor .
12766253	0	pregnane_X_receptor	106,125	CYP3A4_and_multiple_drug_resistance_protein_1	18,63	pregnane X receptor	CYP3A4 and multiple drug resistance protein 1	8856	1576	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Avasimibe induces CYP3A4_and_multiple_drug_resistance_protein_1 gene expression through activation of the pregnane_X_receptor .
15322103	0	pregnane_X_receptor	17,36	HNF-4	53,58	pregnane X receptor	HNF-4	8856	3172	Gene	Gene	interferes|nsubj|START_ENTITY interferes|nmod|END_ENTITY	Ligand-activated pregnane_X_receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha .
18187584	0	pregnane_X_receptor	106,125	Insig-1	135,142	pregnane X receptor	Insig-1	18171(Tax:10090)	231070(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Regulatory cross-talk between drug metabolism and lipid homeostasis : constitutive_androstane_receptor and pregnane_X_receptor increase Insig-1 expression .
10924340	0	pregnane_X_receptor	53,72	Interleukin-6	0,13	pregnane X receptor	Interleukin-6	8856	3569	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-6 negatively regulates the expression of pregnane_X_receptor and constitutively_activated_receptor in primary human hepatocytes .
18540626	0	pregnane_X_receptor	14,33	MDR1	51,55	pregnane X receptor	MDR1	8856	5243	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of pregnane_X_receptor and induction of MDR1 by dietary phytochemicals .
18220558	0	pregnane_X_receptor	27,46	NR1I2	48,53	pregnane X receptor	NR1I2	8856	8856	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A pharmacogenetic study of pregnane_X_receptor -LRB- NR1I2 -RRB- in Han Chinese .
26141049	0	pregnane_X_receptor	15,34	NR1I2	8,13	pregnane X receptor	NR1I2	8856	8856	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of NR1I2 -LRB- pregnane_X_receptor -RRB- polymorphisms in head_and_neck_squamous_cell_carcinoma .
15258100	0	pregnane_X_receptor	61,80	P-glycoprotein	27,41	pregnane X receptor	P-glycoprotein	8856	5243	Gene	Gene	independent|nmod|START_ENTITY independent|amod|END_ENTITY	Levothyroxine up-regulates P-glycoprotein independent of the pregnane_X_receptor .
20082578	0	pregnane_X_receptor	75,94	PXR	96,99	pregnane X receptor	PXR	8856	8856	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of polymorphisms in the 3 ' - untranslated region of the human pregnane_X_receptor -LRB- PXR -RRB- gene associated with variability in cytochrome_P450_3A -LRB- CYP3A -RRB- metabolism .
21402137	0	pregnane_X_receptor	100,119	PXR	121,124	pregnane X receptor	PXR	84385(Tax:10116)	84385(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	3,4-methylenedioxymethamphetamine -LRB- MDMA -RRB- interacts with therapeutic drugs on CYP3A by inhibition of pregnane_X_receptor -LRB- PXR -RRB- activation and catalytic enzyme inhibition .
21496454	0	pregnane_X_receptor	10,29	PXR	31,34	pregnane X receptor	PXR	18171(Tax:10090)	18171(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of pregnane_X_receptor -LRB- PXR -RRB- prototype agonists on chemoprotective and drug metabolizing enzymes in mice .
22829544	0	pregnane_X_receptor	14,33	PXR	35,38	pregnane X receptor	PXR	8856	8856	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of pregnane_X_receptor -LRB- PXR -RRB- function and UGT1A1 gene expression by posttranslational modification of PXR protein .
17003103	0	pregnane_X_receptor	135,154	cytochrome_P450_3A4	54,73	pregnane X receptor	cytochrome P450 3A4	8856	1576	Gene	Gene	involvement|nmod|START_ENTITY induces|nmod|involvement induces|dobj|evidence evidence|amod|END_ENTITY	Photochemotherapeutic agent 8-methoxypsoralen induces cytochrome_P450_3A4 and carboxylesterase HCE2 : evidence on an involvement of the pregnane_X_receptor .
18268015	0	pregnane_X_receptor	41,60	cytochrome_P450_3A4	100,119	pregnane X receptor	cytochrome P450 3A4	8856	1576	Gene	Gene	regulation|nmod|START_ENTITY affects|nsubj|regulation affects|dobj|expression expression|nmod|END_ENTITY	Post-transcriptional regulation of human pregnane_X_receptor by micro-RNA affects the expression of cytochrome_P450_3A4 .
20504912	0	pregnane_X_receptor	90,109	cytochrome_P450_3A4	24,43	pregnane X receptor	cytochrome P450 3A4	8856	1576	Gene	Gene	activation|nmod|START_ENTITY blocking|dobj|activation attenuates|advcl|blocking attenuates|dobj|induction induction|amod|END_ENTITY	Camptothecin attenuates cytochrome_P450_3A4 induction by blocking the activation of human pregnane_X_receptor .
21117944	0	pregnane_X_receptor	20,39	cytochrome_P450_3A4	60,79	pregnane X receptor	cytochrome P450 3A4	8856	1576	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of human pregnane_X_receptor and its target gene cytochrome_P450_3A4 by Chinese herbal compounds and a molecular docking study .
22363234	0	pregnane_X_receptor	131,150	cytochrome_P450_3A4	40,59	pregnane X receptor	cytochrome P450 3A4	8856	1576	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Fucoxanthin attenuates rifampin-induced cytochrome_P450_3A4 -LRB- CYP3A4 -RRB- and multiple_drug_resistance_1 -LRB- MDR1 -RRB- gene expression through pregnane_X_receptor -LRB- PXR -RRB- - mediated pathways in human hepatoma HepG2 and colon_adenocarcinoma LS174T cells .
23707768	0	pregnane_X_receptor	25,44	cytochrome_P450_3A4	73,92	pregnane X receptor	cytochrome P450 3A4	8856	1576	Gene	Gene	START_ENTITY|acl|induce induce|dobj|expression expression|nmod|END_ENTITY	Piperine activates human pregnane_X_receptor to induce the expression of cytochrome_P450_3A4 and multidrug_resistance_protein_1 .
12774017	0	pregnane_X_receptor	63,82	hepatocyte_nuclear_factor_4alpha	12,44	pregnane X receptor	hepatocyte nuclear factor 4alpha	8856	3172	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of the hepatocyte_nuclear_factor_4alpha in control of the pregnane_X_receptor during fetal liver development .
16455805	0	pregnane_X_receptor	40,59	hepatocyte_nuclear_factor_4alpha	76,108	pregnane X receptor	hepatocyte nuclear factor 4alpha	8856	3172	Gene	Gene	talk|compound|START_ENTITY talk|nmod|END_ENTITY	Rifampicin induction of CYP3A4 requires pregnane_X_receptor cross talk with hepatocyte_nuclear_factor_4alpha and coactivators , and suppression of small_heterodimer_partner gene expression .
11706036	0	pregnane_X_receptor	89,108	multidrug_resistance-associated_protein_2	14,55	pregnane X receptor	multidrug resistance-associated protein 2	84385(Tax:10116)	25303(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of multidrug_resistance-associated_protein_2 -LRB- ABCC2 -RRB- by the nuclear receptors pregnane_X_receptor , farnesoid_X-activated_receptor , and constitutive_androstane_receptor .
26920453	0	pregnane_X_receptor	4,23	organic_cation_transporter_1	39,67	pregnane X receptor	organic cation transporter 1	8856	6580	Gene	Gene	down-regulates|nsubj|START_ENTITY down-regulates|dobj|END_ENTITY	The pregnane_X_receptor down-regulates organic_cation_transporter_1 -LRB- SLC22A1 -RRB- in human hepatocytes by squelching SRC-1 coactivator .
23536728	0	pregnane_X_receptor	56,75	p53	25,28	pregnane X receptor	p53	8856	7157	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Tumor suppressor protein p53 negatively regulates human pregnane_X_receptor activity .
19144646	0	pregnane_X_receptor	53,72	protein_arginine_methyltransferase_1	76,112	pregnane X receptor	protein arginine methyltransferase 1	8856	3276	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of transcriptional activity of pregnane_X_receptor by protein_arginine_methyltransferase_1 .
12805410	0	pregnane_X_receptor	49,68	small_heterodimer_partner	4,29	pregnane X receptor	small heterodimer partner	8856	8431	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The small_heterodimer_partner interacts with the pregnane_X_receptor and represses its transcriptional activity .
16144941	0	pregnane_X_receptor	57,76	steroid_and_xenobiotic_receptor	18,49	pregnane X receptor	steroid and xenobiotic receptor	8856	8856	Gene	Gene	Activation|appos|START_ENTITY Activation|nmod|END_ENTITY	Activation of the steroid_and_xenobiotic_receptor -LRB- human pregnane_X_receptor -RRB- by nontaxane microtubule-stabilizing agents .
11807162	0	pregnane_x_receptor	46,65	cyp3a	14,19	pregnane x receptor	cyp3a	8856	1576	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|gene gene|amod|END_ENTITY	Regulation of cyp3a gene transcription by the pregnane_x_receptor .
3593832	0	preimplantation-embryo-development	15,49	Ped	51,54	preimplantation-embryo-development	Ped	110340(Tax:10090)	110340(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage of the preimplantation-embryo-development -LRB- Ped -RRB- gene to the mouse major histocompatibility complex -LRB- MHC -RRB- .
18465999	0	preimplantation-embryo-development	17,51	ped	53,56	preimplantation-embryo-development	ped	110340(Tax:10090)	110340(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Influence of the preimplantation-embryo-development -LRB- ped -RRB- gene on mouse blastocyst differentiation .
12135322	0	preproET-1	17,27	Galpha13	0,8	preproET-1	Galpha13	1906	10672	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Galpha13 induces preproET-1 gene expression via JNK .
12135322	0	preproET-1	17,27	JNK	48,51	preproET-1	JNK	1906	5599	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Galpha13 induces preproET-1 gene expression via JNK .
10894940	0	preprocortistatin	26,43	CORT	50,54	preprocortistatin	CORT	1325	1325	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Fine mapping of the human preprocortistatin gene -LRB- CORT -RRB- to neuroblastoma consensus deletion region 1p36 .3 -- > p36 .2 , but absence of mutations in primary_tumors .
10657497	0	preprodynorphin	59,74	Pdyn	76,80	preprodynorphin	Pdyn	18610(Tax:10090)	18610(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the mouse homolog of the preprodynorphin -LRB- Pdyn -RRB- gene .
9348182	0	preproendothelin-1	27,45	c-myc	54,59	preproendothelin-1	c-myc	24323(Tax:10116)	24577(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Biphasic regulation of the preproendothelin-1 gene by c-myc .
7943650	0	preproenkephalin_A	26,44	PENK	46,50	preproenkephalin A	PENK	5179	5179	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allele frequencies of the preproenkephalin_A -LRB- PENK -RRB- gene CA repeat in Asians , African-Americans , and Caucasians : lack of evidence for different allele frequencies in alcoholics .
18311511	0	preproinsulin	51,64	CD8	6,9	preproinsulin	CD8	3630	925	Gene	Gene	set|nmod|START_ENTITY epitope|acl|set responses|nmod|epitope responses|compound|END_ENTITY	Human CD8 responses to a complete epitope set from preproinsulin : implications for approaches to epitope discovery .
22522618	0	preproinsulin	12,25	CD8	50,53	preproinsulin	CD8	3630	925	Gene	Gene	signal|compound|START_ENTITY signal|acl:relcl|restricted restricted|nsubj|cells cells|compound|END_ENTITY	Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill b-cells .
22943201	0	preproinsulin	29,42	CD8	0,3	preproinsulin	CD8	3630	925	Gene	Gene	autoreactivity|nmod|START_ENTITY autoreactivity|compound|END_ENTITY	CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity .
12062800	0	prepronociceptin	41,57	Sp1	66,69	prepronociceptin	Sp1	5368	6667	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Regulation of transcription of the human prepronociceptin gene by Sp1 .
10984440	0	presenilin	49,59	filamin	36,43	presenilin	filamin	40260(Tax:7227)	42066(Tax:7227)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and genetic interaction of filamin with presenilin in Drosophila .
17947293	0	presenilin	22,32	ubiquilin	0,9	presenilin	ubiquilin	40260(Tax:7227)	32977(Tax:7227)	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila .
24462774	0	presenilin-1	12,24	ErbB4	48,53	presenilin-1	ErbB4	19164(Tax:10090)	13869(Tax:10090)	Gene	Gene	processing|amod|START_ENTITY processing|nmod|END_ENTITY	Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation .
8873134	0	presenilin-1	26,38	PS-1	40,44	presenilin-1	PS-1	5663	5663	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of Alzheimer 's presenilin-1 -LRB- PS-1 -RRB- gene to 14q24 .3 by fluorescence in situ hybridization .
10069390	1	presenilin-1	75,87	PS1	89,92	presenilin-1	PS1	5663	5663	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Five presenilin-1 -LRB- PS1 -RRB- mutations do not alter the sensitivity of PS1 to caspases .
10775535	0	presenilin-1	39,51	PSEN1	53,58	presenilin-1	PSEN1	5663	5663	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Alzheimer 's _ disease due to an intronic presenilin-1 -LRB- PSEN1 intron 4 -RRB- mutation : A clinicopathological study .
9073509	0	presenilin-1	80,92	PSEN1	99,104	presenilin-1	PSEN1	5663	5663	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the 5 ' sequence , genomic structure , and alternative splicing of the presenilin-1 gene -LRB- PSEN1 -RRB- associated with early onset Alzheimer_disease .
11083918	0	presenilin-1	37,49	X11_alpha	0,9	presenilin-1	X11 alpha	5663	320	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	X11_alpha and x11_beta interact with presenilin-1 via their PDZ domains .
12960155	0	presenilin-1	90,102	amyloid_precursor_protein	25,50	presenilin-1	amyloid precursor protein	5663	351	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Notch1 competes with the amyloid_precursor_protein for gamma-secretase and down-regulates presenilin-1 gene expression .
9738936	0	presenilin-1	22,34	beta-catenin	40,52	presenilin-1	beta-catenin	19164(Tax:10090)	12387(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of presenilin-1 with beta-catenin .
9790190	0	presenilin-1	48,60	beta-catenin	19,31	presenilin-1	beta-catenin	5663	1499	Gene	Gene	potentiates|amod|START_ENTITY mutations|nmod|potentiates END_ENTITY|nmod|mutations	Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis .
11116137	0	presenilin-1	81,93	cAMP-response_element-binding_protein	10,47	presenilin-1	cAMP-response element-binding protein	5663	1385	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Activated cAMP-response_element-binding_protein regulates neuronal expression of presenilin-1 .
10677567	0	presenilin-1	100,112	m-calpain	69,78	presenilin-1	m-calpain	5663	824	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Molecular interactions between presenilin and calpain : inhibition of m-calpain protease activity by presenilin-1 , 2 and cleavage of presenilin-1 by m - , mu-calpain .
11158238	0	presenilin-1	18,30	nerve_growth_factor	34,53	presenilin-1	nerve growth factor	29192(Tax:10116)	310738(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	The regulation of presenilin-1 by nerve_growth_factor .
9121700	0	presenilin-2	26,38	PS-2	40,44	presenilin-2	PS-2	5664	5664	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of Alzheimer 's presenilin-2 -LRB- PS-2 -RRB- gene to 1q42 .1 by fluorescence in situ hybridization .
12232783	0	presenilin-2	43,55	PSEN2	57,62	presenilin-2	PSEN2	5664	5664	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulatory region variability in the human presenilin-2 -LRB- PSEN2 -RRB- gene : potential contribution to the gene activity and risk for AD .
18087668	0	presenilin-2	21,33	PSEN2	40,45	presenilin-2	PSEN2	5664	5664	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two polymorphisms of presenilin-2 gene -LRB- PSEN2 -RRB- 5 ' regulatory region are not associated with Alzheimer 's _ disease -LRB- AD -RRB- in the Polish population .
19196715	0	presenilin_1	7,19	BACE1	61,66	presenilin 1	BACE1	19164(Tax:10090)	23821(Tax:10090)	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|expression expression|nmod|END_ENTITY	Mutant presenilin_1 increases the expression and activity of BACE1 .
16738488	0	presenilin_1	35,47	CREB-binding_protein	0,20	presenilin 1	CREB-binding protein	19164(Tax:10090)	12914(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	CREB-binding_protein activation by presenilin_1 but not by its M146L mutant .
11402035	0	presenilin_1	41,53	Glycogen_synthase_kinase-3beta	0,30	presenilin 1	Glycogen synthase kinase-3beta	5663	2932	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Glycogen_synthase_kinase-3beta regulates presenilin_1 C-terminal fragment levels .
9667772	0	presenilin_1	32,44	PS-1	46,50	presenilin 1	PS-1	5663	5663	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Lack of specific association of presenilin_1 -LRB- PS-1 -RRB- protein with plaques and tangles in Alzheimer 's _ disease .
11129109	0	presenilin_1	23,35	PS1	37,40	presenilin 1	PS1	5663	5663	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	No association between presenilin_1 -LRB- PS1 -RRB- intronic polymorphism and sporadic Alzheimer 's _ disease in Koreans .
16300890	0	presenilin_1	59,71	PS1	73,76	presenilin 1	PS1	29192(Tax:10116)	29192(Tax:10116)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Calcium oscillations in type-1 astrocytes , the effect of a presenilin_1 -LRB- PS1 -RRB- mutation .
19181896	0	presenilin_1	12,24	PS1	26,29	presenilin 1	PS1	19164(Tax:10090)	19164(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increase in presenilin_1 -LRB- PS1 -RRB- levels in senescence-accelerated mice -LRB- SAMP8 -RRB- may indirectly impair memory by affecting amyloid_precursor_protein -LRB- APP -RRB- processing .
7550356	0	presenilin_1	21,33	S182	35,39	presenilin 1	S182	5663	5663	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The structure of the presenilin_1 -LRB- S182 -RRB- gene and identification of six novel mutations in early onset AD families .
12354302	0	presenilin_1	22,34	SEL-10	0,6	presenilin 1	SEL-10	5663	55294	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	SEL-10 interacts with presenilin_1 , facilitates its ubiquitination , and alters A-beta peptide production .
17126306	0	presenilin_1	46,58	ZNF237	76,82	presenilin 1	ZNF237	5663	9205	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Analysis of transcriptional modulation of the presenilin_1 gene promoter by ZNF237 , a candidate binding partner of the Ets transcription factor ERM .
11912199	0	presenilin_1	166,178	alpha_7_nicotinic_receptor	85,111	presenilin 1	alpha 7 nicotinic receptor	5663	11441(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|amod|END_ENTITY	Accelerated plaque accumulation , associative learning_deficits , and up-regulation of alpha_7_nicotinic_receptor protein in transgenic_mice co-expressing mutant human presenilin_1 and amyloid precursor proteins .
12460547	0	presenilin_1	11,23	amyloid_precursor_protein	54,79	presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|delivery delivery|nmod|END_ENTITY	A role for presenilin_1 in regulating the delivery of amyloid_precursor_protein to the cell surface .
12831872	0	presenilin_1	91,103	amyloid_precursor_protein	65,90	presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	double-transgenic_mice|amod|START_ENTITY double-transgenic_mice|compound|END_ENTITY	Diffuse_amyloid_deposition , but not plaque number , is reduced in amyloid_precursor_protein / presenilin_1 double-transgenic_mice by pathway lesions .
15772361	0	presenilin_1	29,41	amyloid_precursor_protein	126,151	presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	mutations|nsubj|START_ENTITY mutations|nmod|END_ENTITY	Familial_Alzheimer 's _ disease presenilin_1 mutations cause alterations in the conformation of presenilin and interactions with amyloid_precursor_protein .
18304749	0	presenilin_1	87,99	amyloid_precursor_protein	61,86	presenilin 1	amyloid precursor protein	19164(Tax:10090)	351	Gene	Gene	model|amod|START_ENTITY model|amod|END_ENTITY	Acquisition of conditioned taste aversion is impaired in the amyloid_precursor_protein / presenilin_1 mouse model of Alzheimer 's _ disease .
18583063	0	presenilin_1	151,163	amyloid_precursor_protein	125,150	presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY /|dobj|transgenic_mice /|nsubj|depletion depletion|nmod|immunoreactivity immunoreactivity|nmod|gyrus gyrus|nmod|END_ENTITY	Subfield and layer-specific depletion in calbindin-D28K , calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid_precursor_protein / presenilin_1 transgenic_mice .
19181896	0	presenilin_1	12,24	amyloid_precursor_protein	119,144	presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY Increase|nmod|levels impair|nsubj|Increase impair|advcl|affecting affecting|dobj|END_ENTITY	Increase in presenilin_1 -LRB- PS1 -RRB- levels in senescence-accelerated mice -LRB- SAMP8 -RRB- may indirectly impair memory by affecting amyloid_precursor_protein -LRB- APP -RRB- processing .
20921220	0	presenilin_1	25,37	amyloid_precursor_protein	116,141	presenilin 1	amyloid precursor protein	5663	351	Gene	Gene	domain|amod|START_ENTITY analysis|nmod|domain reveals|nsubj|analysis reveals|dobj|spectrum spectrum|nmod|activity activity|nmod|substrates substrates|amod|END_ENTITY	Mutation analysis of the presenilin_1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid_precursor_protein and other substrates .
22702220	0	presenilin_1	148,160	amyloid_precursor_protein	122,147	presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer 's _ disease -LSB- amyloid_precursor_protein / presenilin_1 -LRB- PS1 -RRB- -RSB- .
26293690	0	presenilin_1	198,210	amyloid_precursor_protein	172,197	presenilin 1	amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|compound|END_ENTITY	By suppressing the expression of anterior_pharynx-defective-1a_and _ -1 b and inhibiting the aggregation of b-amyloid protein , magnesium ions inhibit the cognitive_decline of amyloid_precursor_protein / presenilin_1 transgenic_mice .
19276086	0	presenilin_1	29,41	beta-amyloid_precursor_protein	58,88	presenilin 1	beta-amyloid precursor protein	19164(Tax:10090)	11820(Tax:10090)	Gene	Gene	trafficking|nmod|START_ENTITY regulated|nsubjpass|trafficking regulated|nmod|END_ENTITY	Intracellular trafficking of presenilin_1 is regulated by beta-amyloid_precursor_protein and phospholipase_D1 .
11104755	0	presenilin_1	73,85	glycogen_synthase_kinase-3beta	18,48	presenilin 1	glycogen synthase kinase-3beta	5663	2932	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Substitution of a glycogen_synthase_kinase-3beta phosphorylation site in presenilin_1 separates presenilin function from beta-catenin signaling .
10366748	0	presenilin_1	27,39	notch_1	52,59	presenilin 1	notch 1	5663	4851	Gene	Gene	facilitates|nsubj|START_ENTITY facilitates|dobj|END_ENTITY	The Alzheimer-related gene presenilin_1 facilitates notch_1 in primary mammalian neurons .
10092585	0	presenilin_1	50,62	p0071	86,91	presenilin 1	p0071	5663	8502	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Alzheimer 's _ disease-related presenilin_1 with armadillo protein p0071 .
15246694	0	presenilin_1_and_2	16,34	Notch_receptors	57,72	presenilin 1 and 2	Notch receptors	5663;5664	4851	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|nmod|END_ENTITY	Distribution of presenilin_1_and_2 and their relation to Notch_receptors and ligands in human embryonic/foetal _ central_nervous_system .
8922407	0	presenilin_1_and_2	14,32	PS1	34,37	presenilin 1 and 2	PS1	5663;5664	5663	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of presenilin_1_and_2 -LRB- PS1 and PS2 -RRB- in human and murine tissues .
16212240	0	presenilin_2	7,19	acetylcholinesterase	30,50	presenilin 2	acetylcholinesterase	81751(Tax:10116)	83817(Tax:10116)	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Mutant presenilin_2 increases acetylcholinesterase activity in neuronal cells .
20359505	0	prestin	38,45	VAPA	74,78	prestin	VAPA	80979(Tax:10090)	30960(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between the motor protein prestin and the transporter protein VAPA .
22447932	0	prion_protein	9,22	ADAM8	60,65	prion protein	ADAM8	19122(Tax:10090)	11501(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Cellular prion_protein regulates its own a-cleavage through ADAM8 in skeletal muscle .
7609638	0	prion_protein	13,26	Bcl-2	54,59	prion protein	Bcl-2	5621	596	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	The cellular prion_protein -LRB- PrP -RRB- selectively binds to Bcl-2 in the yeast two-hybrid system .
9344576	0	prion_protein	96,109	Bcl-2	24,29	prion protein	Bcl-2	5621	596	Gene	Gene	vitro|nmod|START_ENTITY fragment|amod|vitro treated|nmod|fragment treated|nsubj|Effect Effect|nmod|flupirtine flupirtine|nmod|level level|amod|END_ENTITY	Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion_protein fragment -LRB- PrP106-126 -RRB- .
10970892	0	prion_protein	44,57	BiP	22,25	prion protein	BiP	5621	3309	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The chaperone protein BiP binds to a mutant prion_protein and mediates its degradation by the proteasome .
26740554	0	prion_protein	9,22	BiP	132,135	prion protein	BiP	5621	2662	Gene	Gene	mutants|compound|START_ENTITY inhibit|nsubj|mutants inhibit|advcl|depleting depleting|dobj|END_ENTITY	Familial prion_protein mutants inhibit Hrd1-mediated retrotranslocation of misfolded proteins by depleting misfolded protein sensor BiP .
15374100	0	prion_protein	15,28	CBP35	39,44	prion protein	CBP35	24686(Tax:10116)	83781(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Interaction of prion_protein mRNA with CBP35 and other cellular proteins : possible implications for prion replication and age-dependent changes .
18462346	0	prion_protein	13,26	CD25	63,67	prion protein	CD25	19122(Tax:10090)	16184(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
18462346	0	prion_protein	13,26	CD4	58,61	prion protein	CD4	19122(Tax:10090)	12504(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
11306558	0	prion_protein	74,87	Doppel	98,104	prion protein	Doppel	19122(Tax:10090)	26434(Tax:10090)	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion_protein homologue Doppel .
15161660	0	prion_protein	55,68	Doppel	69,75	prion protein	Doppel	19122(Tax:10090)	26434(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	Male_infertility and DNA damage in Doppel knockout and prion_protein / Doppel double-knockout mice .
18462346	0	prion_protein	13,26	Foxp3	69,74	prion protein	Foxp3	19122(Tax:10090)	20371(Tax:10090)	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|cells cells|compound|END_ENTITY	The cellular prion_protein is preferentially expressed by CD4 + CD25 + Foxp3 + regulatory T cells .
22036844	0	prion_protein	39,52	Hypoxia-inducible_factor-1_a	0,28	prion protein	Hypoxia-inducible factor-1 a	5621	3091	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor-1_a regulates prion_protein expression to protect against neuron cell damage .
12873216	0	prion_protein	68,81	PRNP	83,87	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Analysis of polymorphic microsatellites within the bovine and ovine prion_protein -LRB- PRNP -RRB- genes .
14727152	0	prion_protein	47,60	PRNP	67,71	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of sequence variability of the bovine prion_protein gene -LRB- PRNP -RRB- in German cattle breeds .
15644519	0	prion_protein	47,60	PRNP	67,71	prion protein	PRNP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The incidence of genotypes at codon 171 of the prion_protein gene -LRB- PRNP -RRB- in five breeds of sheep and production traits of ewes associated with those genotypes .
15739100	0	prion_protein	69,82	PRNP	89,93	prion protein	PRNP	5621	5621	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Creutzfeldt-Jakob_disease in a patient with an R208H mutation of the prion_protein gene -LRB- PRNP -RRB- and a 17-kDa prion_protein fragment .
16690731	0	prion_protein	20,33	PRNP	40,44	prion protein	PRNP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genotyping of ovine prion_protein gene -LRB- PRNP -RRB- variants by PCR with melting curve analysis .
17272863	0	prion_protein	39,52	PRNP	59,63	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	Deletion/insertion polymorphism of the prion_protein gene -LRB- PRNP -RRB- in Polish Holstein-Friesian cattle .
17605301	0	prion_protein	18,31	PRNP	38,42	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the prion_protein gene -LRB- PRNP -RRB- and cellular prion_protein -LRB- PrPc -RRB- in cattle and sheep fetuses and maternal tissues during pregnancy .
18256917	0	prion_protein	24,37	PRNP	39,43	prion protein	PRNP	101087310	101087310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The complete CDS of the prion_protein -LRB- PRNP -RRB- gene of African lion -LRB- Panthera leo -RRB- .
18817311	0	prion_protein	40,53	PRNP	60,64	prion protein	PRNP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphism -LRB- SNP -RRB- in prion_protein gene -LRB- PRNP -RRB- exon-3 in Gaddi sheep .
18941882	0	prion_protein	38,51	PRNP	58,62	prion protein	PRNP	102169975	102169975	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Complete genomic sequence of the goat prion_protein gene -LRB- PRNP -RRB- .
19507705	0	prion_protein	39,52	PRNP	59,63	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	Deletion/insertion polymorphism of the prion_protein gene -LRB- PRNP -RRB- in Polish red cattle , Polish White-backed cattle and European_bison -LRB- Bison_bonasus L. , 1758 -RRB- .
19534429	0	prion_protein	21,34	PRNP	35,39	prion protein	PRNP	5621	5621	Gene	Gene	Polymorphism|nmod|START_ENTITY END_ENTITY|nsubj|Polymorphism	-LSB- Polymorphism of the prion_protein PRNP gene and risk of multiple_sclerosis development in ethnic Russians from Bashkortostan -RSB- .
20198483	0	prion_protein	50,63	PRNP	70,74	prion protein	PRNP	5621	5621	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel seven-octapeptide repeat insertion in the prion_protein gene -LRB- PRNP -RRB- in a Dutch pedigree with Gerstmann-Str ussler-Scheinker disease phenotype : comparison with similar cases from the literature .
21120616	0	prion_protein	20,33	PRNP	40,44	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the prion_protein gene -LRB- PRNP -RRB- in two Chinese indigenous cattle breeds .
22170597	0	prion_protein	20,33	PRNP	40,44	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the prion_protein gene -LRB- PRNP -RRB- in Polish cattle affected by classical bovine_spongiform_encephalopathy .
22412936	0	prion_protein	49,62	PRNP	69,73	prion protein	PRNP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The 5 ' flanking region and intron1 of the bovine prion_protein gene -LRB- PRNP -RRB- are responsible for negative feedback regulation of the prion_protein .
23497519	0	prion_protein	42,55	PRNP	37,41	prion protein	PRNP	5621	5621	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Endoplasmic reticulum stress induces PRNP prion_protein gene expression in breast_cancer .
24287918	0	prion_protein	39,52	PRNP	34,38	prion protein	PRNP	5621	5621	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Up-regulation of mRNA ventricular PRNP prion_protein gene expression in air pollution highly exposed young urbanites : endoplasmic reticulum stress , glucose regulated protein 78 , and nanosized particles .
7485229	0	prion_protein	42,55	PRNP	62,66	prion protein	PRNP	5621	5621	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	SSCP analysis and sequencing of the human prion_protein gene -LRB- PRNP -RRB- detects two different 24 bp deletions in an atypical Alzheimer 's _ disease family .
7999319	0	prion_protein	129,142	PRNP	123,127	prion protein	PRNP	5621	5621	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	A novel mechanism of phenotypic heterogeneity demonstrated by the effect of a polymorphism on a pathogenic mutation in the PRNP -LRB- prion_protein gene -RRB- .
10400714	0	prion_protein	43,56	PrP	58,61	prion protein	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Species-independent inhibition of abnormal prion_protein -LRB- PrP -RRB- formation by a peptide containing a conserved PrP sequence .
11385461	0	prion_protein	70,83	PrP	85,88	prion protein	PrP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Deletion of the alpha -LRB- 1,3 -RRB- galactosyl_transferase -LRB- GGTA1 -RRB- gene and the prion_protein -LRB- PrP -RRB- gene in sheep .
12041690	0	prion_protein	38,51	PrP	53,56	prion protein	PrP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphic distribution of the ovine prion_protein -LRB- PrP -RRB- gene in scrapie-infected sheep flocks in which embryo transfer was used to circumvent the transmissions of scrapie .
12514748	0	prion_protein	38,51	PrP	53,56	prion protein	PrP	5621	5621	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic characterization of the human prion_protein -LRB- PrP -RRB- gene locus .
12679034	0	prion_protein	16,29	PrP	36,39	prion protein	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Soluble dimeric prion_protein binds PrP -LRB- Sc -RRB- in vivo and antagonizes prion disease .
17291697	0	prion_protein	28,41	PrP	43,46	prion protein	PrP	5621	5621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparative analysis of the prion_protein -LRB- PrP -RRB- gene in cetacean species .
17498663	0	prion_protein	65,78	PrP	80,83	prion protein	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Reduced response of splenocytes after mitogen-stimulation in the prion_protein -LRB- PrP -RRB- gene-deficient mouse : PrPLP/Doppel production and cerebral_degeneration .
18574558	0	prion_protein	28,41	PrP	43,46	prion protein	PrP	281427(Tax:9913)	281427(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and expression of a prion_protein -LRB- PrP -RRB- gene from Korean bovine -LRB- Bos_taurus coreanae -RRB- and production of rabbit anti-bovine PrP antibody .
19796688	0	prion_protein	35,48	PrP	50,53	prion protein	PrP	458076(Tax:9598)	458076(Tax:9598)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Inducible expression of chimpanzee prion_protein -LRB- PrP -RRB- in murine PrP knock-out cells .
19796688	0	prion_protein	35,48	PrP	65,68	prion protein	PrP	458076(Tax:9598)	19122(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Inducible expression of chimpanzee prion_protein -LRB- PrP -RRB- in murine PrP knock-out cells .
19956715	0	prion_protein	48,61	PrP	63,66	prion protein	PrP	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Implications of conflicting associations of the prion_protein -LRB- PrP -RRB- gene with scrapie susceptibility and fitness on the persistence of scrapie .
22144895	0	prion_protein	35,48	PrP	50,53	prion protein	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Follicular dendritic cell-specific prion_protein -LRB- PrP -RRB- expression alone is sufficient to sustain prion infection in the spleen .
7494265	0	prion_protein	39,52	PrP	54,57	prion protein	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	Accumulation|nmod|START_ENTITY Accumulation|appos|END_ENTITY	Accumulation of proteinase K-resistant prion_protein -LRB- PrP -RRB- is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob_disease agent .
7815814	0	prion_protein	79,92	PrP	94,97	prion protein	PrP	5621	5621	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A simple and rapid method for sequencing the entire coding region of the human prion_protein -LRB- PrP -RRB- gene .
7902565	0	prion_protein	16,29	PrP	31,34	prion protein	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Ablation of the prion_protein -LRB- PrP -RRB- gene in mice prevents scrapie and facilitates production of anti-PrP antibodies .
9031631	0	prion_protein	22,35	PrP	37,40	prion protein	PrP	100008658(Tax:9986)	100008658(Tax:9986)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a prion_protein -LRB- PrP -RRB- gene from rabbit ; a species with apparent resistance to infection by prions .
9321385	0	prion_protein	41,54	PrP	56,59	prion protein	PrP	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Astrocyte-specific expression of hamster prion_protein -LRB- PrP -RRB- renders PrP knockout mice susceptible to hamster scrapie .
15644272	0	prion_protein	39,52	PrPC	54,58	prion protein	PrPC	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Mitochondrial localization of cellular prion_protein -LRB- PrPC -RRB- invokes neuronal_apoptosis in aged transgenic_mice overexpressing PrPC .
16825956	0	prion_protein	34,47	PrPC	49,53	prion protein	PrPC	5621	5621	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of prion_protein -LRB- PrPC -RRB- in the human forebrain during development .
16957924	0	prion_protein	29,42	PrPC	44,48	prion protein	PrPC	5621	5621	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of the cellular prion_protein -LRB- PrPC -RRB- in brains of livestock and domesticated species .
20926176	0	prion_protein	37,50	PrPC	52,56	prion protein	PrPC	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and knockdown of cellular prion_protein -LRB- PrPC -RRB- in differentiating mouse embryonic stem cells .
26295309	0	prion_protein	35,48	PrPC	50,54	prion protein	PrPC	5621	5621	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Neuroprotective effect of cellular prion_protein -LRB- PrPC -RRB- is related with activation of alpha7 nicotinic acetylcholine receptor -LRB- a7nAchR -RRB- - mediated autophagy flux .
7595362	0	prion_protein	19,32	PrPC	34,38	prion protein	PrPC	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	A cellular form of prion_protein -LRB- PrPC -RRB- exists in many non-neuronal tissues of sheep .
10971411	0	prion_protein	20,33	PrPc	35,39	prion protein	PrPc	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Different levels of prion_protein -LRB- PrPc -RRB- expression on hamster , mouse and human blood cells .
15531106	0	prion_protein	25,38	PrPc	40,44	prion protein	PrPc	19122(Tax:10090)	19122(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of cellular prion_protein -LRB- PrPc -RRB- after focal cerebral_ischemia and influence of lesion severity .
17013787	0	prion_protein	45,58	PrPc	60,64	prion protein	PrPc	281427(Tax:9913)	5621	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression and localization of the cellular prion_protein -LRB- PrPc -RRB- in the cow 's central nervous system .
17875293	0	prion_protein	14,27	PrPc	28,32	prion protein	PrPc	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Functions of prion_protein PrPc -RSB- .
7788502	0	prion_protein	41,54	PrPc	56,60	prion protein	PrPc	5621	5621	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of cellular prion_protein -LRB- PrPc -RRB- in synaptic boutons of normal hamster hippocampus .
9506914	0	prion_protein	68,81	PrPc	83,87	prion protein	PrPc	5621	5621	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Distribution and submicroscopic immunogold localization of cellular prion_protein -LRB- PrPc -RRB- in extracerebral tissues .
9972829	0	prion_protein	41,54	PrPc	56,60	prion protein	PrPc	5621	5621	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Ultrastructural localization of cellular prion_protein -LRB- PrPc -RRB- at the neuromuscular junction .
12064254	0	prion_protein	17,30	Prnp	37,41	prion protein	Prnp	493887(Tax:9940)	493887(Tax:9940)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Influence of the prion_protein gene , Prnp , on scrapie susceptibility in sheep .
26237451	0	prion_protein	63,76	STIP1_homology_and_U-Box-containing_protein_1	113,158	prion protein	STIP1 homology and U-Box-containing protein 1	19122(Tax:10090)	56424;20867	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of novel putative-binding proteins for cellular prion_protein and a specific interaction with the STIP1_homology_and_U-Box-containing_protein_1 .
22985412	0	prion_protein	73,86	ScN2a	90,95	prion protein	ScN2a	5621	6326	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Cytochalasin D enhances the accumulation of a protease-resistant form of prion_protein in ScN2a cells : involvement of PI3 kinase/Akt signalling pathway .
22619325	0	prion_protein	16,29	Sprn	41,45	prion protein	Sprn	19122(Tax:10090)	212518(Tax:10090)	Gene	Gene	START_ENTITY|nmod|gene gene|amod|END_ENTITY	Knockout of the prion_protein -LRB- PrP -RRB- - like Sprn gene does not produce embryonic_lethality in combination with PrP -LRB- C -RRB- - deficiency .
21172064	0	prion_protein	52,65	fyn	69,72	prion protein	fyn	5621	2534	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Signal transduction in neurons : effects of cellular prion_protein on fyn kinase and ERK1/2 kinase .
9396609	0	prion_protein	63,76	laminin_receptor_precursor	17,43	prion protein	laminin receptor precursor	5621	3921	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The human 37-kDa laminin_receptor_precursor interacts with the prion_protein in eukaryotic cells .
11214923	0	prion_protein	65,78	proteinase	30,40	prion protein	proteinase	5621	100616101	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	Specific determination of the proteinase K-resistant form of the prion_protein using two-site immunometric assays .
24133259	0	prion_protein	4,17	stress-inducible_phosphoprotein_1	26,59	prion protein	stress-inducible phosphoprotein 1	19122(Tax:10090)	20867(Tax:10090)	Gene	Gene	ligand|compound|START_ENTITY ligand|amod|END_ENTITY	The prion_protein ligand , stress-inducible_phosphoprotein_1 , regulates amyloid-b oligomer toxicity .
19760599	0	prion_protein	28,41	stress-inducible_protein_1	58,84	prion protein	stress-inducible protein 1	19122(Tax:10090)	20867(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Developmental expression of prion_protein and its ligands stress-inducible_protein_1 and vitronectin .
20837487	0	prion_protein	80,93	stress-inducible_protein_1	111,137	prion protein	stress-inducible protein 1	5621	10963	Gene	Gene	interaction|compound|START_ENTITY induced|nmod|interaction induced|advcl|END_ENTITY	Role of alpha7_nicotinic_acetylcholine_receptor in calcium signaling induced by prion_protein interaction with stress-inducible_protein_1 .
21608082	0	prion_protein	110,123	stress-inducible_protein_1	74,100	prion protein	stress-inducible protein 1	19122(Tax:10090)	20867(Tax:10090)	Gene	Gene	self-renewal|nmod|START_ENTITY self-renewal|nmod|interaction interaction|nmod|END_ENTITY	Enhanced neural progenitor/stem cells self-renewal via the interaction of stress-inducible_protein_1 with the prion_protein .
21980981	0	prion_protein	70,83	tumour_necrosis_factor_a	19,43	prion protein	tumour necrosis factor a	5621	7124	Gene	Gene	apoptosis|nmod|START_ENTITY apoptosis|compound|END_ENTITY	Resistance against tumour_necrosis_factor_a apoptosis by the cellular prion_protein is cell-specific for oral , colon_and_kidney_cancer cell lines .
17504807	0	prion_protein	9,22	vitronectin	40,51	prion protein	vitronectin	19122(Tax:10090)	22370(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|nmod|END_ENTITY	Cellular prion_protein interaction with vitronectin supports axonal_growth and is compensated by integrins .
12623063	0	prion_protein-encoding	17,39	PRNP	41,45	prion protein-encoding	PRNP	5621	5621	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Stability of the prion_protein-encoding -LRB- PRNP -RRB- gene in HeLa cells .
3379103	0	pro-GRP	99,106	GRP	119,122	pro-GRP	GRP	2922	2922	Gene	Gene	synthesize|dobj|START_ENTITY synthesize|nmod|END_ENTITY	Swiss 3T3 mouse embryo fibroblasts transfected with a human prepro-GRP gene synthesize and secrete pro-GRP rather than GRP .
24723213	0	pro-gastrin_releasing_peptide	31,60	ProGRP	62,68	pro-gastrin releasing peptide	ProGRP	2922	2922	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Reference intervals for plasma pro-gastrin_releasing_peptide -LRB- ProGRP -RRB- levels in healthy adults of Chinese Han ethnicity .
8939968	0	pro-gelatinase_A	51,67	Membrane_type_matrix_metalloproteinase_1	0,40	pro-gelatinase A	Membrane type matrix metalloproteinase 1	4313	4323	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Membrane_type_matrix_metalloproteinase_1 activates pro-gelatinase_A without furin cleavage of the N-terminal domain .
25585051	0	pro-opiomelanocortin	32,52	Atg12	8,13	pro-opiomelanocortin	Atg12	18976(Tax:10090)	67526(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Loss of Atg12 , but not Atg5 , in pro-opiomelanocortin neurons exacerbates diet-induced obesity .
12844338	0	pro-opiomelanocortin	16,36	IGF-I	0,5	pro-opiomelanocortin	IGF-I	18976(Tax:10090)	16000(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	IGF-I regulates pro-opiomelanocortin and GH gene expression in the mouse pituitary gland .
9392508	0	pro-opiomelanocortin	30,50	Leptin	0,6	pro-opiomelanocortin	Leptin	18976(Tax:10090)	16846(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus .
21266325	0	pro-opiomelanocortin	20,40	Lkb1	12,16	pro-opiomelanocortin	Lkb1	18976(Tax:10090)	20869(Tax:10090)	Gene	Gene	neurons|amod|START_ENTITY END_ENTITY|nmod|neurons	Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice .
10395956	0	pro-opiomelanocortin	54,74	POMC	76,80	pro-opiomelanocortin	POMC	422011(Tax:9031)	422011(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the chicken pro-opiomelanocortin -LRB- POMC -RRB- gene .
11578531	0	pro-opiomelanocortin	22,42	POMC	44,48	pro-opiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Ablation of pituitary pro-opiomelanocortin -LRB- POMC -RRB- cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model .
11596869	0	pro-opiomelanocortin	12,32	POMC	34,38	pro-opiomelanocortin	POMC	5443	5443	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ontogeny of pro-opiomelanocortin -LRB- POMC -RRB- gene expression and translated products adrenocorticotrophin -LRB- ACTH -RRB- and alpha-melanocyte_stimulating_hormone -LRB- alpha-MSH -RRB- in the ovine fetal pituitary gland .
12032760	0	pro-opiomelanocortin	25,45	POMC	47,51	pro-opiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence analysis of the pro-opiomelanocortin -LRB- POMC -RRB- gene in obese/diabetic Japanese .
12165561	0	pro-opiomelanocortin	71,91	POMC	93,97	pro-opiomelanocortin	POMC	5443	5443	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin -LRB- POMC -RRB- increases susceptibility to early-onset obesity through a novel molecular mechanism .
15864412	0	pro-opiomelanocortin	77,97	POMC	104,108	pro-opiomelanocortin	POMC	5443	5443	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of single nucleotide polymorphisms in the promoter region of the pro-opiomelanocortin gene -LRB- POMC -RRB- with low bone_mineral_density in adult women .
21187100	0	pro-opiomelanocortin	41,61	POMC	63,67	pro-opiomelanocortin	POMC	422011(Tax:9031)	422011(Tax:9031)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Feather follicles express two classes of pro-opiomelanocortin -LRB- POMC -RRB- mRNA using alternative promoters in chickens .
23430746	0	pro-opiomelanocortin	95,115	POMC	117,121	pro-opiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MicroRNA 375 mediates the signaling pathway of corticotropin-releasing_factor -LRB- CRF -RRB- regulating pro-opiomelanocortin -LRB- POMC -RRB- expression by targeting mitogen-activated_protein_kinase_8 .
24094067	0	pro-opiomelanocortin	32,52	POMC	54,58	pro-opiomelanocortin	POMC	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Down-regulation of hypothalamic pro-opiomelanocortin -LRB- POMC -RRB- expression after weaning is associated with hyperphagia-induced obesity in JCR rats overexpressing neuropeptide_Y .
25377161	0	pro-opiomelanocortin	23,43	POMC	45,49	pro-opiomelanocortin	POMC	5443	5443	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Positive expression of pro-opiomelanocortin -LRB- POMC -RRB- is a novel independent poor prognostic marker in surgically resected non-small_cell_lung_cancer .
2542089	0	pro-opiomelanocortin	14,34	POMC	36,40	pro-opiomelanocortin	POMC	281416(Tax:9913)	281416(Tax:9913)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of pro-opiomelanocortin -LRB- POMC -RRB- by a vaccinia_virus transient expression system and in vitro processing of the expressed prohormone by POMC-converting enzyme .
2698828	0	pro-opiomelanocortin	32,52	POMC	54,58	pro-opiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Tissue-specific activity of the pro-opiomelanocortin -LRB- POMC -RRB- gene and repression by glucocorticoids .
2998878	0	pro-opiomelanocortin	21,41	POMC	43,47	pro-opiomelanocortin	POMC	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the rat pro-opiomelanocortin -LRB- POMC -RRB- gene .
7829983	0	pro-opiomelanocortin	36,56	POMC	58,62	pro-opiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	ANF -LRB- 1-28 -RRB- is a potent suppressor of pro-opiomelanocortin -LRB- POMC -RRB- mRNA but a weak inhibitor of beta EP-LI release from AtT-20 cells .
7958386	0	pro-opiomelanocortin	35,55	POMC	57,61	pro-opiomelanocortin	POMC	5443	5443	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Presence of the same transcript of pro-opiomelanocortin -LRB- POMC -RRB- genes in the porcine anterior and intermediate pituitary lobes .
9786167	0	pro-opiomelanocortin	14,34	POMC	36,40	pro-opiomelanocortin	POMC	5443	5443	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of pro-opiomelanocortin -LRB- POMC -RRB- in the cerebral_ganglion and ovary of a protochordate .
1475014	0	pro-opiomelanocortin	24,44	Prolactin	0,9	pro-opiomelanocortin	Prolactin	24664(Tax:10116)	24683(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Prolactin regulation of pro-opiomelanocortin gene expression in the arcuate nucleus of the rat hypothalamus .
8132649	0	pro-opiomelanocortin	114,134	RESP18	0,6	pro-opiomelanocortin	RESP18	24664(Tax:10116)	50561(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	RESP18 , a novel endocrine secretory protein transcript , and four other transcripts are regulated in parallel with pro-opiomelanocortin in melanotropes .
7492314	0	pro-opiomelanocortin	103,123	Translocon-associated_protein_TRAP_delta	0,40	pro-opiomelanocortin	Translocon-associated protein TRAP delta	380532(Tax:8355)	397945(Tax:8355)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Translocon-associated_protein_TRAP_delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary .
16033098	0	proGRP	31,37	SCC	108,111	proGRP	SCC	2922	6317	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Pro-gastrin-releasing_peptide -LRB- proGRP -RRB- in patients with benign and malignant diseases : comparison with CEA , SCC , CYFRA_21-1_and_NSE in patients with lung_cancer .
24174628	0	proMMP-9	124,132	TIMP-1	87,93	proMMP-9	TIMP-1	17395(Tax:10090)	7076	Gene	Gene	complexed|nmod|START_ENTITY END_ENTITY|acl|complexed	Angiogenic capacity of M1 - and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9 .
7798020	0	proTRH	93,99	prothyrotrophin-releasing_hormone	58,91	proTRH	prothyrotrophin-releasing hormone	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Starvation-induced changes in the hypothalamic content of prothyrotrophin-releasing_hormone -LRB- proTRH -RRB- mRNA and the hypothalamic release of proTRH-derived peptides : role of the adrenal gland .
12884364	0	probasin	40,48	p202	67,71	probasin	p202	54192(Tax:10090)	26388(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Prostate-specific antitumor activity by probasin promoter-directed p202 expression .
1370825	1	procarboxypeptidase_B	132,153	pancreas-specific_protein	92,117	procarboxypeptidase B	pancreas-specific protein	1360	1360	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of pancreas-specific_protein as pancreatic procarboxypeptidase_B .
12080079	0	procaspase-3	97,109	CD8	133,136	procaspase-3	CD8	836	925	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Selective inhibition of dipeptidyl_peptidase_I , not caspases , prevents the partial processing of procaspase-3 in CD3-activated human CD8 -LRB- + -RRB- T lymphocytes .
10803458	0	procaspase-3	80,92	Hsp27	0,5	procaspase-3	Hsp27	836	3315	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Hsp27 functions as a negative regulator of cytochrome_c-dependent activation of procaspase-3 .
25286301	0	procollagen_C-proteinase_enhancer-1	18,53	PCPE-1	55,61	procollagen C-proteinase enhancer-1	PCPE-1	5118	5118	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	The NTR domain of procollagen_C-proteinase_enhancer-1 -LRB- PCPE-1 -RRB- mediates PCPE-1 binding to syndecans-1 , _ -2 _ and _ -4 as well as fibronectin .
19468819	0	prodynorphin	22,34	PDYN	36,40	prodynorphin	PDYN	5173	5173	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|appos|END_ENTITY	Gene polymorphisms in prodynorphin -LRB- PDYN -RRB- are associated with episodic memory in the elderly .
25048760	0	prodynorphin	60,72	PDYN	74,78	prodynorphin	PDYN	5173	5173	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between VNTR polymorphism in promoter region of prodynorphin -LRB- PDYN -RRB- gene and heroin_dependence .
8476611	0	prodynorphin	100,112	c-fos	87,92	prodynorphin	c-fos	29190(Tax:10116)	314322(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Molecular mechanisms of pain : serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons .
2512642	0	proenkephalin	14,27	Fos	31,34	proenkephalin	Fos	5179	2353	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of proenkephalin by Fos and Jun. .
1478730	0	proenkephalin	29,42	Interleukin-1_beta	0,18	proenkephalin	Interleukin-1 beta	29237(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-1_beta regulates proenkephalin gene expression in astrocytes cultured from rat cortex .
11985352	0	proenkephalin	14,27	PENK	29,33	proenkephalin	PENK	18619(Tax:10090)	18619(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of proenkephalin -LRB- PENK -RRB- mRNA in inflammatory leukocytes during experimental peritonitis in Swiss mice .
1331650	0	proenkephalin	70,83	endothelin-1	122,134	proenkephalin	endothelin-1	5179	1906	Gene	Gene	expression|compound|START_ENTITY Stimulation|nmod|expression Stimulation|nmod|END_ENTITY	Stimulation of c-fos and c-jun gene expression and down-regulation of proenkephalin gene expression in C6 glioma cells by endothelin-1 .
7501282	0	proenkephalin_and_tyrosine_hydroxylase	34,72	c-fos	27,32	proenkephalin and tyrosine hydroxylase	c-fos	29237;25085	314322(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of c-fos , proenkephalin_and_tyrosine_hydroxylase gene expression by metrazole in the hamster adrenal and hippocampus .
18230613	0	profilin-1	76,86	STAT3	32,37	profilin-1	STAT3	64303(Tax:10116)	25125(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1 .
23430586	0	profilin_1	112,122	miRNA-182	38,47	profilin 1	miRNA-182	5216	406958	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Expression and regulatory function of miRNA-182 in triple-negative_breast_cancer cells through its targeting of profilin_1 .
7559545	0	progelatinase_A	35,50	Thrombin	0,8	progelatinase A	Thrombin	4313	2147	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Thrombin induces the activation of progelatinase_A in vascular endothelial cells .
11235994	0	progelatinase_A	38,53	membrane-type_1_matrix_metalloproteinase	66,106	progelatinase A	membrane-type 1 matrix metalloproteinase	4313	4323	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Enhanced production and activation of progelatinase_A mediated by membrane-type_1_matrix_metalloproteinase in human oral_squamous_cell_carcinomas : implications for lymph_node_metastasis .
9212749	0	progelatinase_A	73,88	membrane-type_1_matrix_metalloproteinase	14,54	progelatinase A	membrane-type 1 matrix metalloproteinase	4313	4323	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of membrane-type_1_matrix_metalloproteinase and activation of progelatinase_A in human osteoarthritic cartilage .
10363975	0	progelatinase_a	88,103	MT5-MMP	45,52	progelatinase a	MT5-MMP	4313	10893	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Identification and characterization of human MT5-MMP , a new membrane-bound activator of progelatinase_a overexpressed in brain_tumors .
3760122	0	progestagen-associated_endometrial_protein	33,75	PEP	77,80	progestagen-associated endometrial protein	PEP	5047	5047	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Luteal phase concentrations of a progestagen-associated_endometrial_protein -LRB- PEP -RRB- in the serum of cycling women with adequate or inadequate endometrium .
16109739	0	progesterone_receptor	54,75	BRCA1	38,43	progesterone receptor	BRCA1	5241	672	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The breast_cancer susceptibility gene BRCA1 regulates progesterone_receptor signaling in mammary epithelial cells .
16741564	0	progesterone_receptor	14,35	BRCA1	49,54	progesterone receptor	BRCA1	5241	672	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|acl|signaling signaling|nmod|END_ENTITY	Regulation of progesterone_receptor signaling by BRCA1 in mammary cancer .
21531767	0	progesterone_receptor	67,88	BRCA1	0,5	progesterone receptor	BRCA1	5241	672	Gene	Gene	leading|xcomp|START_ENTITY ubiquitination|acl|leading counteracts|nmod|ubiquitination counteracts|nsubj|END_ENTITY	BRCA1 counteracts progesterone action by ubiquitination leading to progesterone_receptor degradation and epigenetic silencing of target promoters .
24955763	0	progesterone_receptor	24,45	CRISPLD2	0,8	progesterone receptor	CRISPLD2	5241	83716	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	CRISPLD2 is a target of progesterone_receptor and its expression is decreased in women with endometriosis .
2631032	0	progesterone_receptor	37,58	Epidermal_growth_factor	1,24	progesterone receptor	Epidermal growth factor	100724945	100714471	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	-LSB- Epidermal_growth_factor induces the progesterone_receptor in fetal uterine cells in culture : antagonistic effect of antiestrogens -RSB- .
12706304	0	progesterone_receptor	41,62	Estrogen_receptor_alpha	0,23	progesterone receptor	Estrogen receptor alpha	5241	2099	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Estrogen_receptor_alpha and Sp1 regulate progesterone_receptor gene expression .
16452193	0	progesterone_receptor	24,45	GATA5	0,5	progesterone receptor	GATA5	5241	140628	Gene	Gene	promoter|compound|START_ENTITY activation|nmod|promoter activation|nummod|END_ENTITY	GATA5 activation of the progesterone_receptor gene promoter in breast_cancer cells is influenced by the +331 G/A polymorphism .
8164686	0	progesterone_receptor	39,60	HMG-1	24,29	progesterone receptor	HMG-1	5241	10354	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	The DNA-bending protein HMG-1 enhances progesterone_receptor binding to its target DNA sequences .
10875927	0	progesterone_receptor	34,55	HOXA5	0,5	progesterone receptor	HOXA5	5241	3202	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	HOXA5 regulates expression of the progesterone_receptor .
14500577	0	progesterone_receptor	46,67	Immune-responsive_gene_1	0,24	progesterone receptor	Immune-responsive gene 1	18667(Tax:10090)	16365(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Immune-responsive_gene_1 is a novel target of progesterone_receptor and plays a critical role during implantation in the mouse .
10722692	0	progesterone_receptor	29,50	JAB1	0,4	progesterone receptor	JAB1	5241	10987	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	JAB1 interacts with both the progesterone_receptor and SRC-1 .
16033068	0	progesterone_receptor	27,48	PGR	50,53	progesterone receptor	PGR	5241	5241	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the human progesterone_receptor -LRB- PGR -RRB- gene of two human prostate_adenocarcinoma cell lines .
16352595	0	progesterone_receptor	51,72	PPM1D	31,36	progesterone receptor	PPM1D	5241	8493	Gene	Gene	regulating|dobj|START_ENTITY END_ENTITY|acl|regulating	Dual roles for the phosphatase PPM1D in regulating progesterone_receptor function .
18621128	0	progesterone_receptor	51,72	PR	74,76	progesterone receptor	PR	100724945	100724945	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regional changes in the spatio-temporal pattern of progesterone_receptor -LRB- PR -RRB- expression in the guinea-pig genital tract as parturition approaches .
9717846	0	progesterone_receptor	21,42	PR	44,46	progesterone receptor	PR	25154(Tax:10116)	25154(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Hormone induction of progesterone_receptor -LRB- PR -RRB- messenger ribonucleic_acid and activation of PR promoter regions in ovarian granulosa cells : evidence for a role of cyclic_adenosine_3 ' ,5 ' - monophosphate but not estradiol .
25037596	0	progesterone_receptor	27,48	PgR	55,58	progesterone receptor	PgR	5241	5241	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the +331 G/A progesterone_receptor gene -LRB- PgR -RRB- polymorphism with risk of endometrial_cancer in Caucasian women : a meta-analysis .
20605949	0	progesterone_receptor	149,170	RANKL	10,15	progesterone receptor	RANKL	18667(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY absence|nmod|expression branching|nmod|absence ordered|xcomp|branching induces|dep|ordered induces|nsubj|END_ENTITY	Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone_receptor expression .
21550420	0	progesterone_receptor	14,35	cyclin_dependent_kinases_1_and_2	48,80	progesterone receptor	cyclin dependent kinases 1 and 2	5241	983;1017	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Regulation of progesterone_receptor activity by cyclin_dependent_kinases_1_and_2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus .
2783381	0	progesterone_receptor	33,54	epidermal_growth_factor	84,107	progesterone receptor	epidermal growth factor	5241	1950	Gene	Gene	production|compound|START_ENTITY Decrease|nmod|production Decrease|nmod|implication implication|amod|END_ENTITY	Decrease in estradiol-stimulated progesterone_receptor production in MCF-7 cells by epidermal_growth_factor and possible clinical implication for paracrine-regulated breast_cancer growth .
2783569	0	progesterone_receptor	95,116	epidermal_growth_factor	51,74	progesterone receptor	epidermal growth factor	5241	1950	Gene	Gene	induction|nmod|START_ENTITY antagonize|nmod|induction antagonize|dobj|effect effect|nmod|END_ENTITY	Antiestrogens antagonize the stimulatory effect of epidermal_growth_factor on the induction of progesterone_receptor in fetal uterine cells in culture .
19620495	0	progesterone_receptor	19,40	epidermal_growth_factor_receptor_2	48,82	progesterone receptor	epidermal growth factor receptor 2	5241	2064	Gene	Gene	Estrogen_receptor|appos|START_ENTITY Estrogen_receptor|appos|END_ENTITY	Estrogen_receptor , progesterone_receptor , human epidermal_growth_factor_receptor_2 -LRB- HER2 -RRB- , and epidermal_growth_factor_receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic_breast_cancer .
24351599	0	progesterone_receptor	35,56	epidermal_growth_factor_receptor_2	67,101	progesterone receptor	epidermal growth factor receptor 2	5241	2064	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	-LSB- Reliability of estrogen_receptor , progesterone_receptor and human epidermal_growth_factor_receptor_2 expression in breast_cancer evaluated by immunohistochemistry -RSB- .
10678068	0	progesterone_receptor	80,101	estrogen_receptor	61,78	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	START_ENTITY|nsubj|prediction prediction|amod|END_ENTITY	-LSB- Prognosis prediction of S-phase fraction and p53 , c-erbB-2 , estrogen_receptor , progesterone_receptor in axillary node-negative breast_cancer -RSB- .
12208729	0	progesterone_receptor	117,138	estrogen_receptor	14,31	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	correlation|nmod|START_ENTITY breast_cancer|dep|correlation cx|xcomp|breast_cancer cx|nsubj|Expression Expression|nmod|END_ENTITY	Expression of estrogen_receptor -LRB- ER -RRB- -LRB- beta -RRB- cx protein in ER -LRB- alpha -RRB- - positive breast_cancer : specific correlation with progesterone_receptor .
12385821	0	progesterone_receptor	60,81	estrogen_receptor	29,46	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Transdominant suppression of estrogen_receptor signaling by progesterone_receptor ligands in uterine leiomyoma cells .
15084345	0	progesterone_receptor	99,120	estrogen_receptor	23,40	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	B-isoform|amod|START_ENTITY expression|nmod|B-isoform mechanism|dep|expression mechanism|nmod|END_ENTITY	Molecular mechanism of estrogen_receptor -LRB- ER -RRB- alpha-specific , estradiol-dependent expression of the progesterone_receptor -LRB- PR -RRB- B-isoform .
17387718	0	progesterone_receptor	57,78	estrogen_receptor	24,41	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	negative|appos|START_ENTITY analysis|dep|negative analysis|nmod|END_ENTITY	Descriptive analysis of estrogen_receptor -LRB- ER -RRB- - negative , progesterone_receptor -LRB- PR -RRB- - negative , and HER2-negative invasive breast_cancer , the so-called triple-negative phenotype : a population-based study from the California_cancer Registry .
17638866	0	progesterone_receptor	86,107	estrogen_receptor	67,84	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	START_ENTITY|dep|expressed expressed|nmod|END_ENTITY	The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen_receptor / progesterone_receptor / HER-2 breast_carcinomas .
18413639	0	progesterone_receptor	57,78	estrogen_receptor	38,55	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	approximated|advmod|START_ENTITY approximated|nmod|END_ENTITY	Breast_cancer subtype approximated by estrogen_receptor , progesterone_receptor , and HER-2 is associated with local and distant recurrence after breast-conserving therapy .
1846309	0	progesterone_receptor	55,76	estrogen_receptor	36,53	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	determination|appos|START_ENTITY determination|nmod|END_ENTITY	Immunocytochemical determination of estrogen_receptor , progesterone_receptor , and_1 ,25 - dihydroxyvitamin_D3 receptor in breast_cancer and relationship to prognosis .
2018347	0	progesterone_receptor	87,108	estrogen_receptor	22,39	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	expression|nmod|START_ENTITY associated|nmod|expression associated|nsubj|change change|nmod|gene gene|compound|END_ENTITY	Somatic change in the estrogen_receptor gene associated with altered expression of the progesterone_receptor .
22931039	0	progesterone_receptor	46,67	estrogen_receptor	13,30	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	negative|appos|START_ENTITY Frequency|dep|negative Frequency|nmod|END_ENTITY	Frequency of estrogen_receptor -LRB- ER -RRB- - negative , progesterone_receptor -LRB- PR -RRB- - negative , and HER2-negative invasive breast_cancer , the so-called triple-negative phenotype : a population-based study from Trentino , North East Italy .
23818346	0	progesterone_receptor	46,67	estrogen_receptor	27,44	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	Ki-67|dep|START_ENTITY Ki-67|compound|END_ENTITY	Prognostic significance of estrogen_receptor , progesterone_receptor , HER2/neu , Ki-67 , and nm23 expression in patients with invasive_breast_cancer .
24570392	0	progesterone_receptor	52,73	estrogen_receptor	108,125	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	expression|nmod|START_ENTITY higher|nsubj|expression higher|nmod|that that|nmod|END_ENTITY	In pulmonary_lymphangioleiomyomatosis expression of progesterone_receptor is frequently higher than that of estrogen_receptor .
6261932	0	progesterone_receptor	125,146	estrogen_receptor	82,99	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|dep|localization	Most cystosarcoma_phyllodes and fibroadenomas have progesterone_receptor but lack estrogen_receptor : stromal localization of progesterone_receptor .
8745507	0	progesterone_receptor	57,78	estrogen_receptor	38,55	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	proliferation|dep|START_ENTITY proliferation|compound|END_ENTITY	-LSB- Research on the relationship between estrogen_receptor , progesterone_receptor , cell proliferation associated antigen in uterine leiomyoma and nuclear body density of myoma , serum reproductive hormone concentrations -RSB- .
8986784	0	progesterone_receptor	38,59	estrogen_receptor	83,100	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene parallel|nsubj|transcription parallel|dobj|occupancy occupancy|compound|END_ENTITY	Estrogen-induced transcription of the progesterone_receptor gene does not parallel estrogen_receptor occupancy .
9524123	0	progesterone_receptor	44,65	estrogen_receptor	86,103	progesterone receptor	estrogen receptor	5241	2099	Gene	Gene	pathway|nmod|START_ENTITY Activation|nmod|pathway Activation|nmod|END_ENTITY	Activation of the Src/p21ras/Erk pathway by progesterone_receptor via cross-talk with estrogen_receptor .
10459849	0	progesterone_receptor	75,96	insulin-like_growth_factor_binding_protein-1	18,62	progesterone receptor	insulin-like growth factor binding protein-1	5241	3484	Gene	Gene	promoter|nmod|START_ENTITY promoter|amod|END_ENTITY	Activation of the insulin-like_growth_factor_binding_protein-1 promoter by progesterone_receptor in decidualized human endometrial stromal cells .
12416559	0	progesterone_receptor	52,73	mdm2	18,22	progesterone receptor	mdm2	5241	4193	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Overexpression of mdm2 and p53 and association with progesterone_receptor expression in benign_meningiomas .
11479298	0	progesterone_receptor	14,35	p42_MAPK	52,60	progesterone receptor	p42 MAPK	373629(Tax:8355)	398985(Tax:8355)	Gene	Gene	associates|nsubj|START_ENTITY associates|nmod|END_ENTITY	The classical progesterone_receptor associates with p42_MAPK and is involved in phosphatidylinositol_3-kinase signaling in Xenopus oocytes .
21284604	0	progesterone_receptor	4,25	phospholipase_D1	62,78	progesterone receptor	phospholipase D1	5241	5337	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	The progesterone_receptor as a transcription factor regulates phospholipase_D1 expression through independent activation of protein kinase A and Ras during 8-Br-cAMP-induced decidualization in human endometrial stromal cells .
11668597	0	progesterone_receptor	96,117	prolactin_receptor	49,67	progesterone receptor	prolactin receptor	5241	5618	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Transcriptional and spatiotemporal regulation of prolactin_receptor mRNA and cooperativity with progesterone_receptor function during ductal branch growth in the mammary gland .
15668243	0	progesterone_receptor	112,133	protein-associated_splicing_factor	43,77	progesterone receptor	protein-associated splicing factor	5241	6421	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of the protein-associated_splicing_factor as a negative co-regulator of the progesterone_receptor .
21637418	0	progesterone_receptor_membrane_component_2	59,101	PGRMC2	103,109	progesterone receptor membrane component 2	PGRMC2	100048965(Tax:9823)	100048965(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning , mapping and molecular characterization of porcine progesterone_receptor_membrane_component_2 -LRB- PGRMC2 -RRB- gene .
21263073	0	programmed_cell_death-1	24,47	IFN-a	0,5	programmed cell death-1	IFN-a	18566(Tax:10090)	111654(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY promotes|dobj|transcription promotes|nsubj|END_ENTITY	IFN-a directly promotes programmed_cell_death-1 transcription and limits the duration of T cell-mediated immunity .
11854457	0	programmed_cell_death-2	10,33	PDCD2	35,40	programmed cell death-2	PDCD2	5134	5134	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human programmed_cell_death-2 -LRB- PDCD2 -RRB- gene is a target of BCL6 repression : implications for a role of BCL6 in the down-regulation of apoptosis .
23296900	0	programmed_cell_death_4	78,101	MicroRNA-182	0,12	programmed cell death 4	MicroRNA-182	27250	406958	Gene	Gene	targeting|dobj|START_ENTITY promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-182 promotes cell growth , invasion , and chemoresistance by targeting programmed_cell_death_4 -LRB- PDCD4 -RRB- in human ovarian_carcinomas .
18372920	0	programmed_cell_death_4	58,81	MicroRNA-21	0,11	programmed cell death 4	MicroRNA-21	27250	406991	Gene	Gene	gene|amod|START_ENTITY targeting|dobj|gene promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-21 promotes cell transformation by targeting the programmed_cell_death_4 gene .
24650454	0	programmed_cell_death_4	87,110	MicroRNA-21	0,11	programmed cell death 4	MicroRNA-21	27250	406991	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	MicroRNA-21 regulates biological behaviors in papillary_thyroid_carcinoma by targeting programmed_cell_death_4 .
25400316	0	programmed_cell_death_4	60,83	MicroRNA-21	0,11	programmed cell death 4	MicroRNA-21	18569(Tax:10090)	387140(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY targeting|dobj|gene promotes|advcl|targeting promotes|nsubj|END_ENTITY	MicroRNA-21 promotes cell growth and migration by targeting programmed_cell_death_4 gene in Kazakh 's esophageal_squamous_cell_carcinoma .
25738901	0	programmed_cell_death_4	73,96	MicroRNA-21	0,11	programmed cell death 4	MicroRNA-21	27250	406991	Gene	Gene	apoptosis|nmod|START_ENTITY modulates|dobj|apoptosis modulates|nsubj|END_ENTITY	MicroRNA-21 , induced by high glucose , modulates macrophage apoptosis via programmed_cell_death_4 .
20455770	0	programmed_cell_death_4	26,49	PDCD4	19,24	programmed cell death 4	PDCD4	18569(Tax:10090)	18569(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Decreased level of PDCD4 -LRB- programmed_cell_death_4 -RRB- protein activated cell proliferation in the lung of A/J mouse .
22586265	0	programmed_cell_death_4	22,45	PDCD4	47,52	programmed cell death 4	PDCD4	27250	27250	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulatory effects of programmed_cell_death_4 -LRB- PDCD4 -RRB- protein in interferon -LRB- IFN -RRB- - stimulated gene expression and generation of type I IFN responses .
23827854	0	programmed_cell_death_4	102,125	PDCD4	127,132	programmed cell death 4	PDCD4	27250	27250	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Aldose reductase inhibition suppresses colon_cancer cell viability by modulating microRNA-21 mediated programmed_cell_death_4 -LRB- PDCD4 -RRB- expression .
25519906	0	programmed_cell_death_4	35,58	PDCD4	60,65	programmed cell death 4	PDCD4	27250	27250	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Post-transcriptional regulation of programmed_cell_death_4 -LRB- PDCD4 -RRB- mRNA by the RNA-binding proteins human antigen R -LRB- HuR -RRB- and T-cell_intracellular_antigen_1 -LRB- TIA1 -RRB- .
26063221	0	programmed_cell_death_4	86,109	miR-183	0,7	programmed cell death 4	miR-183	27250	406959	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-183 regulates biological behavior in papillary_thyroid_carcinoma by targeting the programmed_cell_death_4 .
25175929	0	programmed_cell_death_4	21,44	miR-21	0,6	programmed cell death 4	miR-21	27250	406991	Gene	Gene	proliferation|amod|START_ENTITY increases|dep|proliferation increases|amod|END_ENTITY	miR-21 increases the programmed_cell_death_4 gene-regulated cell proliferation in head and neck squamous_carcinoma cell lines .
23877371	0	programmed_cell_death_4	78,101	microRNA-182	18,30	programmed cell death 4	microRNA-182	27250	406958	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|Downregulation Downregulation|nmod|END_ENTITY	Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed_cell_death_4 in human lung_adenocarcinoma cells .
21088996	0	programmed_cell_death_4	86,109	microRNA-21	13,24	programmed cell death 4	microRNA-21	27250	406991	Gene	Gene	death|nmod|START_ENTITY inhibits|dobj|death inhibits|nsubj|Knockdown Knockdown|nmod|END_ENTITY	Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed_cell_death_4 -LRB- PDCD4 -RRB- in pancreatic_ductal_adenocarcinoma .
23827854	0	programmed_cell_death_4	102,125	microRNA-21	81,92	programmed cell death 4	microRNA-21	27250	406991	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Aldose reductase inhibition suppresses colon_cancer cell viability by modulating microRNA-21 mediated programmed_cell_death_4 -LRB- PDCD4 -RRB- expression .
24786924	0	programmed_cell_death_4	101,124	microRNA-21	33,44	programmed cell death 4	microRNA-21	27250	406991	Gene	Gene	expression|amod|START_ENTITY associated|nmod|expression associated|nsubj|expression expression|nmod|END_ENTITY	Higher expression of whole blood microRNA-21 in patients with ankylosing_spondylitis associated with programmed_cell_death_4 mRNA expression and collagen cross-linked C-telopeptide concentration .
24959246	0	programmed_cell_death_4	56,79	microRNA-21	14,25	programmed cell death 4	microRNA-21	27250	406991	Gene	Gene	tensin|amod|START_ENTITY expression|nmod|tensin upregulates|dobj|expression upregulates|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of microRNA-21 upregulates the expression of programmed_cell_death_4 and phosphatase tensin homologue in the A431 squamous_cell_carcinoma cell line .
14601303	0	programmed_cell_death_5	21,44	PDCD5	46,51	programmed cell death 5	PDCD5	9141	9141	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Characterization of programmed_cell_death_5 -LRB- PDCD5 -RRB- gene in human cartilage and its possible significance -RSB- .
23327497	0	programmed_cell_death_5	26,49	PDCD5	51,56	programmed cell death 5	PDCD5	9141	9141	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Plasma and synovial fluid programmed_cell_death_5 -LRB- PDCD5 -RRB- levels are inversely associated with TNF-a and disease activity in patients with rheumatoid_arthritis .
23638963	0	programmed_cell_death_5	19,42	PDCD5	44,49	programmed cell death 5	PDCD5	9141	9141	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	The involvement of programmed_cell_death_5 -LRB- PDCD5 -RRB- in the regulation of apoptosis in cerebral_ischemia / reperfusion injury .
24614334	0	programmed_cell_death_5	21,44	PDCD5	46,51	programmed cell death 5	PDCD5	292814(Tax:10116)	292814(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Autophagic effect of programmed_cell_death_5 -LRB- PDCD5 -RRB- after focal cerebral ischemic_reperfusion_injury in rats .
19761702	0	programmed_cell_death_factor_4	15,45	PDCD4	47,52	programmed cell death factor 4	PDCD4	27250	27250	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of programmed_cell_death_factor_4 -LRB- PDCD4 -RRB- with hepatocellular_carcinoma and smoking in a Chinese male population .
26798582	0	programmed_cell_death_ligand-1	32,62	Programmed_cell_death_protein-1	0,31	programmed cell death ligand-1	Programmed cell death protein-1	29126	100513601	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|dep|pathway	Programmed_cell_death_protein-1 / programmed_cell_death_ligand-1 pathway inhibition and predictive biomarkers : understanding transforming_growth_factor-beta role .
24982420	0	programmed_cell_death_protein_4	31,62	PDCD4	64,69	programmed cell death protein 4	PDCD4	27250	27250	Gene	Gene	degradation|nmod|START_ENTITY degradation|appos|END_ENTITY	LPS induces the degradation of programmed_cell_death_protein_4 -LRB- PDCD4 -RRB- to release Twist2 , activating c-Maf transcription to promote interleukin-10 production .
22111549	0	programmed_cell_death_protein_4	51,82	pdcd4	84,89	programmed cell death protein 4	pdcd4	27250	27250	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter cloning and characterization of the human programmed_cell_death_protein_4 -LRB- pdcd4 -RRB- gene : evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators .
23656249	0	programmed_cell_death_protein_5	6,37	PDCD5	39,44	programmed cell death protein 5	PDCD5	9141	9141	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum programmed_cell_death_protein_5 -LRB- PDCD5 -RRB- levels is upregulated in liver_diseases .
20382886	0	programmed_death-1	107,125	CD25	59,63	programmed death-1	CD25	18566(Tax:10090)	16184(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY augment|parataxis|involvement augment|iobj|function function|nmod|+ +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20382886	0	programmed_death-1	107,125	CD4	54,57	programmed death-1	CD4	18566(Tax:10090)	12504(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY augment|parataxis|involvement augment|iobj|function function|nmod|+ +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
20713771	0	programmed_death-1	10,28	CD4	43,46	programmed death-1	CD4	5133	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Increased programmed_death-1 expression on CD4 + T cells in cutaneous_T-cell_lymphoma : implications for immune suppression .
20382886	0	programmed_death-1	107,125	Foxp3	65,70	programmed death-1	Foxp3	18566(Tax:10090)	20371(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY augment|parataxis|involvement augment|iobj|function function|nmod|+ +|compound|END_ENTITY	Endothelial cells augment the suppressive function of CD4 + CD25 + Foxp3 + regulatory T cells : involvement of programmed_death-1 and IL-10 .
12847138	0	programmed_death-1	21,39	PD-1	41,45	programmed death-1	PD-1	18566(Tax:10090)	18566(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Critical role of the programmed_death-1 -LRB- PD-1 -RRB- pathway in regulation of experimental autoimmune encephalomyelitis .
16265694	0	programmed_death-1	23,41	PD-L1	49,54	programmed death-1	PD-L1	5133	29126	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Enhanced expression of programmed_death-1 -LRB- PD-1 -RRB- / PD-L1 in salivary glands of patients with Sj __ gren 's _ syndrome .
24586872	0	programmed_death-1	16,34	PD1	36,39	programmed death-1	PD1	18566(Tax:10090)	18566(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Blockade of the programmed_death-1 -LRB- PD1 -RRB- pathway undermines potent genetic protection from type 1 diabetes .
16530813	0	programmed_death-1_ligand-1	36,63	PD-L1	65,70	programmed death-1 ligand-1	PD-L1	29126	29126	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of programmed_death-1_ligand-1 -LRB- PD-L1 -RRB- in gastric_carcinoma and its clinical significance .
16613922	0	programmed_death-ligand_2	15,40	PD-L2	42,47	programmed death-ligand 2	PD-L2	58205(Tax:10090)	58205(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of programmed_death-ligand_2 -LRB- PD-L2 -RRB- in the development of experimental_allergic_conjunctivitis in mice .
18455515	0	programmed_death_1	8,26	CD8	56,59	programmed death 1	CD8	5133	925	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	Dynamic programmed_death_1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis_B .
18799583	0	programmed_death_1	48,66	Nef	36,39	programmed death 1	Nef	5133	6285	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef induces programmed_death_1 expression through a p38 mitogen-activated protein kinase-dependent mechanism .
18799583	0	programmed_death_1	48,66	p38	88,91	programmed death 1	p38	5133	1432	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|mechanism mechanism|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef induces programmed_death_1 expression through a p38 mitogen-activated protein kinase-dependent mechanism .
18183624	0	progranulin	36,47	GRN	49,52	progranulin	GRN	2896	2896	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization of novel progranulin -LRB- GRN -RRB- mutations in frontotemporal_dementia .
21154232	0	progranulin	139,150	GRN	152,155	progranulin	GRN	2896	2896	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal_lobar_degeneration -LRB- FTLD -RRB- with progranulin -LRB- GRN -RRB- mutation .
22072213	0	progranulin	4,15	GRN	17,20	progranulin	GRN	2896	2896	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	The progranulin -LRB- GRN -RRB- Cys157LysfsX97 mutation is associated with nonfluent variant of primary progressive aphasia clinical phenotype .
20930269	0	progranulin	108,119	PGRN	126,130	progranulin	PGRN	2896	2896	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Intra-familial clinical heterogeneity due to FTLD-U with TDP-43_proteinopathy caused by a novel deletion in progranulin gene -LRB- PGRN -RRB- .
26600492	0	progranulin	10,21	PGRN	23,27	progranulin	PGRN	2896	2896	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of progranulin -LRB- PGRN -RRB- on the proliferation and senescence of cervical cancer cells .
21178100	0	progranulin	19,30	TMEM106B	0,8	progranulin	TMEM106B	2896	54664	Gene	Gene	levels|compound|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers .
22509390	0	progranulin	14,25	matrix_metalloproteinase-12	90,117	progranulin	matrix metalloproteinase-12	2896	4321	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix_metalloproteinase-12 -LRB- MMP-12 -RRB- .
22509390	0	progranulin	75,86	matrix_metalloproteinase-12	90,117	progranulin	matrix metalloproteinase-12	2896	4321	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix_metalloproteinase-12 -LRB- MMP-12 -RRB- .
22509390	0	progranulin	14,25	progranulin	75,86	progranulin	progranulin	2896	2896	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix_metalloproteinase-12 -LRB- MMP-12 -RRB- .
22509390	0	progranulin	75,86	progranulin	14,25	progranulin	progranulin	2896	2896	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix_metalloproteinase-12 -LRB- MMP-12 -RRB- .
17324931	0	prohibitin	42,52	Interleukin-6	0,13	prohibitin	Interleukin-6	5245	3569	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells .
24133204	0	prohibitin	29,39	MicroRNA-27	0,11	prohibitin	MicroRNA-27	5245	407018	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-27 -LRB- miR-27 -RRB- targets prohibitin and impairs adipocyte differentiation and mitochondrial function in human adipose-derived stem cells .
22431190	0	prohibitin	86,96	STAT3	101,106	prohibitin	STAT3	25344(Tax:10116)	25125(Tax:10116)	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|compound|END_ENTITY	Interleukin_6 protects H -LRB- 2 -RRB- O -LRB- 2 -RRB- - induced cardiomyocytes_injury through upregulation of prohibitin via STAT3 phosphorylation .
22388104	0	prohibitin	125,135	VP1	33,36	prohibitin	VP1	5245	65130(Tax:10116)	Gene	Gene	modulating|dobj|START_ENTITY suppresses|advcl|modulating suppresses|nsubj|END_ENTITY	Recombinant viral capsid protein VP1 suppresses migration and invasion of human cervical_cancer by modulating phosphorylated prohibitin in lipid rafts .
26751773	0	prohibitin	23,33	aP2	43,46	prohibitin	aP2	18673(Tax:10090)	21418(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Expression of a mutant prohibitin from the aP2 gene promoter leads to obesity-linked_tumor development in insulin resistance-dependent manner .
21914039	0	prohibitin	19,29	caspase-3	59,68	prohibitin	caspase-3	25344(Tax:10116)	25402(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|amod|END_ENTITY	Less expression of prohibitin is associated with increased caspase-3 expression and cell apoptosis in renal_interstitial_fibrosis rats .
15173318	0	prohibitin_2	10,22	Akt	0,3	prohibitin 2	Akt	12034(Tax:10090)	11651(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Akt binds prohibitin_2 and relieves its repression of MyoD and muscle differentiation .
21689744	0	prohibitin_2	23,35	CaMK_IV	0,7	prohibitin 2	CaMK IV	12034(Tax:10090)	12326(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	CaMK_IV phosphorylates prohibitin_2 and regulates prohibitin_2-mediated repression of MEF2 transcription .
7615876	0	prohormone_convertase	5,26	PC2	27,30	prohormone convertase	PC2	5126	5126	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Frog prohormone_convertase PC2 mRNA has a mammalian-like expression pattern in the central nervous system and is colocalized with a subset of thyrotropin-releasing_hormone-expressing neurons .
10630414	0	prohormone_convertase_1	14,37	PC1	39,42	prohormone convertase 1	PC1	18548(Tax:10090)	18548(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of prohormone_convertase_1 -LRB- PC1 -RRB- by gp130-related cytokines .
11120670	0	prohormone_convertase_1	14,37	PC1	39,42	prohormone convertase 1	PC1	25204(Tax:10116)	25204(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of prohormone_convertase_1 -LRB- PC1 -RRB- by thyroid hormone .
16274843	0	prohormone_convertase_1	14,37	PC1	39,42	prohormone convertase 1	PC1	5122	5122	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of prohormone_convertase_1 -LRB- PC1 -RRB- expression in cholecystokinin -LRB- CCK -RRB- expressing At-T20 cells decreased cellular content and secretion of CCK and caused a shift in molecular forms of CCK secreted .
9359835	0	prohormone_convertase_2	20,43	EGR-1	90,95	prohormone convertase 2	EGR-1	5126	1958	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of human prohormone_convertase_2 promoter activity by the transcription factor EGR-1 .
24047795	0	prohormone_convertase_2	26,49	PAX6	7,11	prohormone convertase 2	PAX6	18549(Tax:10090)	18508(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Mutant PAX6 downregulates prohormone_convertase_2 expression in mouse islets .
12586766	0	prohormone_convertase_2	83,106	cystatin-related_epididymal_spermatogenic_protein	4,53	prohormone convertase 2	cystatin-related epididymal spermatogenic protein	18549(Tax:10090)	13012(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	The cystatin-related_epididymal_spermatogenic_protein inhibits the serine protease prohormone_convertase_2 .
1374016	0	proinsulin	17,27	Galanin	0,7	proinsulin	Galanin	16334(Tax:10090)	14419(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I -LRB- 7-37 -RRB- in mouse_insulinoma beta_TC-1 cells .
16448523	0	proinsulin	20,30	IGFBP-1	59,66	proinsulin	IGFBP-1	3630	3484	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	The serum levels of proinsulin and their relationship with IGFBP-1 in obese children .
7828304	0	proinsulin	63,73	PAI-1	53,58	proinsulin	PAI-1	3630	5054	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of plasminogen_activator_inhibitor_type-1 _ -LRB- PAI-1 -RRB- by proinsulin and insulin in vivo .
9737940	0	proinsulin	115,125	PAI-1	100,105	proinsulin	PAI-1	3630	5054	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 -LRB- PAI-1 -RRB- gene by proinsulin and insulin in vivo .
26947243	0	proinsulin	53,63	PDIA6	20,25	proinsulin	PDIA6	3630	10130	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A prominent role of PDIA6 in processing of misfolded proinsulin .
4738897	0	proinsulin	19,29	Proinsulin	1,11	proinsulin	Proinsulin	397415(Tax:9823)	397415(Tax:9823)	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|dep|-RSB-	-LSB- Proinsulin -- swine proinsulin -RSB- .
8577925	0	proinsulin	22,32	galanin	11,18	proinsulin	galanin	16334(Tax:10090)	14419(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY END_ENTITY|nmod|mRNA	Effects of galanin on proinsulin mRNA and insulin biosynthesis in normal islets .
15579757	0	proinsulin	54,64	insulin	84,91	proinsulin	insulin	3630	3630	Gene	Gene	START_ENTITY|dep|ratio ratio|compound|END_ENTITY	Rosiglitazone , but not glyburide , reduces circulating proinsulin and the proinsulin : insulin ratio in type 2 diabetes .
632300	0	proinsulin	95,105	insulin-like_growth_factor_I	33,61	proinsulin	insulin-like growth factor I	3630	3479	Gene	Gene	sequence|nmod|START_ENTITY sequence|nmod|END_ENTITY	The amino_acid sequence of human insulin-like_growth_factor_I and its structural homology with proinsulin .
12727576	0	proinsulin	21,31	proinsulin	9,19	proinsulin	proinsulin	3630	3630	Gene	Gene	START_ENTITY|nsubj|Insulin Insulin|appos|END_ENTITY	Insulin , proinsulin , proinsulin : insulin ratio , and the risk of developing type_2_diabetes_mellitus in women .
12727576	0	proinsulin	9,19	proinsulin	21,31	proinsulin	proinsulin	3630	3630	Gene	Gene	Insulin|appos|START_ENTITY END_ENTITY|nsubj|Insulin	Insulin , proinsulin , proinsulin : insulin ratio , and the risk of developing type_2_diabetes_mellitus in women .
7799967	0	prointerleukin_1_beta	33,54	IL1B	61,65	prointerleukin 1 beta	IL1B	3553	3553	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Monocyte expression of the human prointerleukin_1_beta gene -LRB- IL1B -RRB- is dependent on promoter sequences which bind the hematopoietic transcription factor Spi-1 / PU .1 .
15031321	0	prolactin	27,36	Activin	0,7	prolactin	Activin	5617	83729	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Activin inhibits pituitary prolactin expression and cell growth through Smads , Pit-1_and_menin .
9402849	0	prolactin	61,70	CD4	121,124	prolactin	CD4	5617	920	Gene	Gene	correlate|compound|START_ENTITY correlate|nmod|expression expression|nmod|isoforms isoforms|nmod|blood blood|compound|END_ENTITY	Serum levels of interleukin-1_beta , luteinizing hormone , and prolactin correlate with the expression of CD45 isoforms on CD4 + peripheral blood T lymphocytes in healthy women .
21980073	0	prolactin	17,26	CEBPD	0,5	prolactin	CEBPD	24683(Tax:10116)	25695(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	CEBPD suppresses prolactin expression and prolactinoma cell proliferation .
21153249	0	prolactin	20,29	Calcitonin	0,10	prolactin	Calcitonin	24683(Tax:10116)	24241(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Calcitonin inhibits prolactin gene transcription in rat pituitary cells .
12606478	0	prolactin	71,80	Decysin	0,7	prolactin	Decysin	19109(Tax:10090)	58860(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Decysin , a new member of the metalloproteinase family , is regulated by prolactin and steroids during mouse pregnancy .
2965754	0	prolactin	45,54	Dopamine_D-1_receptor	0,21	prolactin	Dopamine D-1 receptor	5617	1812	Gene	Gene	secretion|compound|START_ENTITY stimulation|nmod|secretion stimulation|amod|END_ENTITY	Dopamine_D-1_receptor agonist stimulation of prolactin secretion in man .
1899191	0	prolactin	22,31	Endothelin-3	0,12	prolactin	Endothelin-3	24683(Tax:10116)	366270(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Endothelin-3 inhibits prolactin and stimulates LH , FSH and TSH secretion from pituitary cell culture .
2323487	0	prolactin	51,60	Epidermal_growth_factor	0,23	prolactin	Epidermal growth factor	24683(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Epidermal_growth_factor and phorbol_ester regulate prolactin gene expression via distinct pathways .
8388615	0	prolactin	39,48	Epidermal_growth_factor	0,23	prolactin	Epidermal growth factor	24683(Tax:10116)	25313(Tax:10116)	Gene	Gene	synthesis|amod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates the prolactin synthesis and secretion in rat pituitary cells in culture -LRB- GH4C1 cells -RRB- by increasing the intracellular concentration of free calcium .
15103226	0	prolactin	17,26	Ghrelin	0,7	prolactin	Ghrelin	24683(Tax:10116)	59301(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Ghrelin inhibits prolactin secretion in prepubertal rats .
15380861	0	prolactin	78,87	Growth_hormone	0,14	prolactin	Growth hormone	5617	2688	Gene	Gene	response|compound|START_ENTITY responses|dep|response responses|compound|END_ENTITY	Growth_hormone , cortisol and prolactin responses to physical exercise : higher prolactin response in depressed patients .
4030438	0	prolactin	79,88	Growth_hormone	0,14	prolactin	Growth hormone	5617	2688	Gene	Gene	hypersecretion|nmod|START_ENTITY pituitary_adenomas|nmod|hypersecretion pituitary_adenomas|amod|END_ENTITY	Growth_hormone producing pituitary_adenomas with concomitant hypersecretion of prolactin are particularly sensitive to photon irradiation .
6777767	0	prolactin	16,25	Growth_hormone	0,14	prolactin	Growth hormone	5617	2688	Gene	Gene	responses|compound|START_ENTITY END_ENTITY|dobj|responses	Growth_hormone , prolactin and thyrotrophin responses to thyrotrophin-releasing_hormone in diabetic patients .
2656248	0	prolactin	48,57	Insulin	0,7	prolactin	Insulin	5617	3630	Gene	Gene	synthesis|nmod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Insulin stimulates the synthesis and release of prolactin from human decidual cells .
9591782	0	prolactin	44,53	Insulin-like_growth_factor-1	0,28	prolactin	Insulin-like growth factor-1	24683(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor-1 stimulates rat prolactin gene expression by a Ras , ETS and phosphatidylinositol 3-kinase dependent mechanism .
26486515	0	prolactin	47,56	Insulin-like_growth_factor_1	0,28	prolactin	Insulin-like growth factor 1	791526(Tax:7955)	114433(Tax:7955)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Insulin-like_growth_factor_1 -LRB- IGF-1 -RRB- regulates prolactin , growth hormone , and IGF-1 receptor expression in the pituitary gland of the gilthead sea bream Sparus aurata .
2973977	0	prolactin	69,78	Insulin-like_growth_factor_I	0,28	prolactin	Insulin-like growth factor I	5617	3479	Gene	Gene	synthesis|nmod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Insulin-like_growth_factor_I stimulates the synthesis and release of prolactin from human decidual cells .
2342469	0	prolactin	94,103	Interferon-regulatory_factor_1	0,30	prolactin	Interferon-regulatory factor 1	19109(Tax:10090)	16362(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Interferon-regulatory_factor_1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells .
10022437	0	prolactin	52,61	Interleukin-2	0,13	prolactin	Interleukin-2	5617	3558	Gene	Gene	synthesis|nmod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Interleukin-2 inhibits the synthesis and release of prolactin from human decidual cells .
7508935	0	prolactin	58,67	JAK2	50,54	prolactin	JAK2	24683(Tax:10116)	24514(Tax:10116)	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Activation of receptor-associated tyrosine kinase JAK2 by prolactin .
17519522	0	prolactin	18,27	Janus_kinase_2	120,134	prolactin	Janus kinase 2	24683(Tax:10116)	24514(Tax:10116)	Gene	Gene	rats|amod|START_ENTITY effects|nmod|rats mediated|nsubjpass|effects mediated|nmod|activity activity|compound|END_ENTITY	Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance -LRB- HAA -RRB- rats may be mediated through Janus_kinase_2 -LRB- Jak2 -RRB- activity .
344872	0	prolactin	10,19	LH-RH	52,57	prolactin	LH-RH	5617	2796	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolactin on the LH response to synthetic LH-RH in ovariectomized ewes .
6300718	0	prolactin	146,155	LH-RH	0,5	prolactin	LH-RH	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	pituitary_tumor|amod|START_ENTITY bearing|dobj|pituitary_tumor levels|acl|bearing levels|amod|END_ENTITY	LH-RH and dopamine levels in hypophysial stalk plasma and their relationship to plasma gonadotrophins and prolactin levels in male rats bearing a prolactin - and adrenocorticotrophin-secreting pituitary_tumor .
189552	0	prolactin	76,85	LH_receptor	118,129	prolactin	LH receptor	24683(Tax:10116)	25477(Tax:10116)	Gene	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Localization of prolactin binding in prostate and testis : The role of serum prolactin concentration on the testicular LH_receptor .
12574225	0	prolactin	37,46	Leukemia_inhibitory_factor	0,26	prolactin	Leukemia inhibitory factor	5617	3976	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Leukemia_inhibitory_factor regulates prolactin secretion in prolactinoma and lactotroph cells .
24882100	0	prolactin	45,54	Macrophage_colony-stimulating_factor	0,36	prolactin	Macrophage colony-stimulating factor	24683(Tax:10116)	78965(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Macrophage_colony-stimulating_factor induces prolactin expression in rat pituitary gland .
7070589	0	prolactin	27,36	Neurotensin	0,11	prolactin	Neurotensin	24683(Tax:10116)	299757(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Neurotensin stimulation of prolactin secretion in vitro .
21146499	0	prolactin	53,62	Nur77	28,33	prolactin	Nur77	5617	3164	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells .
9757048	0	prolactin	23,32	Orphanin_FQ	0,11	prolactin	Orphanin FQ	24683(Tax:10116)	25516(Tax:10116)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Orphanin_FQ stimulates prolactin and growth hormone release in male and female rats .
23340249	0	prolactin	81,90	PAK1	23,27	prolactin	PAK1	5617	5058	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Tyrosyl phosphorylated PAK1 regulates breast_cancer cell motility in response to prolactin through filamin_A .
12970160	0	prolactin	14,23	PRL	25,28	prolactin	PRL	5617	5617	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of prolactin -LRB- PRL -RRB- - induced proliferative signals in breast_cancer cells by a molecular mimic of phosphorylated PRL , S179D-PRL .
16648817	0	prolactin	36,45	PRL	52,55	prolactin	PRL	280901(Tax:9913)	280901(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel polymorphism of the porcine prolactin gene -LRB- PRL -RRB- .
3137402	0	prolactin	73,82	PRL	84,87	prolactin	PRL	5617	5617	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Use of a pharmacokinetic model to characterize the thyrotropin -LRB- TSH -RRB- and prolactin -LRB- PRL -RRB- response to thyrotropin-releasing_hormone -LRB- THR -RRB- in man .
6196473	0	prolactin	14,23	PRL	25,28	prolactin	PRL	5617	5617	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of prolactin -LRB- PRL -RRB- on human fetal lung and liver protein synthesis in vitro .
6349706	0	prolactin	27,36	PRL	38,41	prolactin	PRL	5617	5617	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunofluorescent study on prolactin -LRB- PRL -RRB- synthesis in human fetal adenohypophysis .
7997234	0	prolactin	18,27	PRL	29,32	prolactin	PRL	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of rat prolactin -LRB- PRL -RRB- storage by coexpression of human PRL .
10936041	0	prolactin	33,42	Pit-1	66,71	prolactin	Pit-1	396453(Tax:9031)	374215(Tax:9031)	Gene	Gene	START_ENTITY|nmod|factor factor|amod|END_ENTITY	Molecular cloning of the chicken prolactin gene and activation by Pit-1 and cAMP-induced factor in GH3 cells .
8243297	0	prolactin	62,71	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	prolactin	Pituitary adenylate cyclase-activating polypeptide	24683(Tax:10116)	24166(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide stimulates prolactin gene expression in a rat pituitary cell line .
3091193	0	prolactin	159,168	Prl	170,173	prolactin	Prl	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	The effect of unilateral decortication on the patterns of pulsatile follicle stimulating hormone -LRB- FSH -RRB- and luteinizing hormone -LRB- LH -RRB- release and on mean plasma prolactin -LRB- Prl -RRB- levels in the ovariectomized rat .
10499541	0	prolactin	41,50	Progesterone_receptor	0,21	prolactin	Progesterone receptor	5617	5241	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Progesterone_receptor regulates decidual prolactin expression in differentiating human endometrial stromal cells .
8119890	0	prolactin	58,67	RAF-1	88,93	prolactin	RAF-1	24683(Tax:10116)	24703(Tax:10116)	Gene	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	Prolactin induces rapid phosphorylation and activation of prolactin receptor-associated RAF-1 kinase in a T-cell line .
15677474	0	prolactin	44,53	STAT5	112,117	prolactin	STAT5	5617	6776	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|interacting interacting|nmod|END_ENTITY	Suppressor_of_cytokine_signaling_7 inhibits prolactin , growth_hormone , and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation .
15855883	0	prolactin	11,20	STAT5	85,90	prolactin	STAT5	24683(Tax:10116)	24918(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|evidence evidence|nmod|modulation modulation|nmod|expression expression|nummod|END_ENTITY	Effects of prolactin on hypothalamic supraoptic neurones : evidence for modulation of STAT5 expression and electrical activity .
6150065	0	prolactin	22,31	Somatostatin	0,12	prolactin	Somatostatin	5617	6750	Gene	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Somatostatin inhibits prolactin release from the lactotroph primed with oestrogen and cyproterone_acetate in man .
11694349	0	prolactin	20,29	Sp1	0,3	prolactin	Sp1	5617	6667	Gene	Gene	activation|compound|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Sp1 is required for prolactin activation of the interferon_regulatory_factor-1 gene .
9175624	0	prolactin	29,38	Sp1	13,16	prolactin	Sp1	24683(Tax:10116)	24790(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Induction of Sp1 activity by prolactin and interleukin-2 in Nb2 T-cells : differential association of Sp1-DNA complexes with Stats .
15677474	0	prolactin	44,53	Suppressor_of_cytokine_signaling_7	0,34	prolactin	Suppressor of cytokine signaling 7	5617	30837	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Suppressor_of_cytokine_signaling_7 inhibits prolactin , growth_hormone , and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation .
18775765	0	prolactin	15,24	TEAD1	0,5	prolactin	TEAD1	5617	7003	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells .
1802676	0	prolactin	23,32	TNF-alpha	10,19	prolactin	TNF-alpha	24683(Tax:10116)	24835(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effect of TNF-alpha on prolactin secretion from rat anterior pituitary and dopamine release from the hypothalamus : comparison with the effect of interleukin-1_beta .
108096	0	prolactin	6,15	TRH	29,32	prolactin	TRH	5617	7200	Gene	Gene	responses|compound|START_ENTITY Serum|dobj|responses Serum|nmod|END_ENTITY	Serum prolactin responses to TRH in recurrent breast_cancer patients .
1332473	0	prolactin	58,67	TRH	81,84	prolactin	TRH	5617	7200	Gene	Gene	verapamil|nmod|START_ENTITY responses|amod|verapamil blockade|nmod|responses Effects|nmod|blockade Effects|nmod|END_ENTITY	Effects of calcium channel blockade with verapamil on the prolactin responses to TRH , L-dopa , and bromocriptine .
1355520	0	prolactin	83,92	TRH	164,167	prolactin	TRH	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY suppresses|dobj|secretion suppresses|nmod|END_ENTITY	Intraventricular administration of thyrotrophin-releasing_hormone -LRB- TRH -RRB- suppresses prolactin secretion and synthesis : a possible involvement of dopamine release by TRH from rat hypothalamus .
1355520	0	prolactin	83,92	TRH	67,70	prolactin	TRH	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY suppresses|dobj|secretion suppresses|nsubj|administration administration|appos|END_ENTITY	Intraventricular administration of thyrotrophin-releasing_hormone -LRB- TRH -RRB- suppresses prolactin secretion and synthesis : a possible involvement of dopamine release by TRH from rat hypothalamus .
19289102	0	prolactin	126,135	TRH	113,116	prolactin	TRH	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression involvement|acl|induced involvement|appos|END_ENTITY	Possible involvement of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced prolactin gene expression .
1947441	0	prolactin	15,24	TRH	68,71	prolactin	TRH	5617	7200	Gene	Gene	response|compound|START_ENTITY Changes|nmod|response Changes|appos|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- throughout the proliferative phases in the ovulatory and anovulatory menstrual cycle .
3119699	0	prolactin	10,19	TRH	69,72	prolactin	TRH	5617	7200	Gene	Gene	responsiveness|nsubj|START_ENTITY responsiveness|xcomp|thyrotropin-releasing_hormone thyrotropin-releasing_hormone|dobj|END_ENTITY	Subnormal prolactin responsiveness to thyrotropin-releasing_hormone -LRB- TRH -RRB- in women with primary_empty_sella_syndrome .
401551	0	prolactin	20,29	TRH	62,65	prolactin	TRH	5617	7200	Gene	Gene	thyrotrophin|amod|START_ENTITY response|nsubj|thyrotrophin response|xcomp|END_ENTITY	Serum thyrotrophin , prolactin and growth_hormone , response to TRH during oestrogen treatment .
404311	0	prolactin	15,24	TRH	68,71	prolactin	TRH	5617	7200	Gene	Gene	response|compound|START_ENTITY Changes|nmod|response Changes|appos|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- during the menstrual cycle of normal women .
6774631	1	prolactin	134,143	TRH	245,248	prolactin	TRH	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|compound|START_ENTITY Variation|nmod|content Variation|nmod|thyrotropin-releasing_hormone thyrotropin-releasing_hormone|appos|END_ENTITY	Variation in prolactin content of individual cell colonies , and dynamics of stimulation with thyrotropin-releasing_hormone -LRB- TRH -RRB- .
7511776	0	prolactin	17,26	TRH	0,3	prolactin	TRH	5617	7200	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|dep|mediator	TRH : mediator of prolactin in the prostate ?
20302576	0	prolactin	68,77	Thyrotropin-releasing_hormone	0,29	prolactin	Thyrotropin-releasing hormone	5617	7200	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Thyrotropin-releasing_hormone and oestrogen differentially regulate prolactin and prolactin_receptor expression in female human skin and hair follicles in vitro .
3096691	0	prolactin	45,54	Thyrotropin-releasing_hormone	0,29	prolactin	Thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY stimulation|nmod|secretion stimulation|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin secretion is coordinately but not synergistically regulated by an elevation of cytoplasmic calcium and 1,2-diacylglycerol .
3925367	0	prolactin	53,62	Thyrotropin-releasing_hormone	0,29	prolactin	Thyrotropin-releasing hormone	5617	7200	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Thyrotropin-releasing_hormone provocative release of prolactin and thyrotropin in acute head_injury .
6418746	1	prolactin	126,135	Thyrotropin-releasing_hormone	51,80	prolactin	Thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene stimulates|dobj|transcription stimulates|nsubj|END_ENTITY	Thyrotropin-releasing_hormone rapidly stimulates both transcription of the prolactin gene and the phosphorylation of a specific nuclear protein .
6787084	0	prolactin	45,54	Thyrotropin-releasing_hormone	0,29	prolactin	Thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|compound|START_ENTITY stimulation|nmod|release stimulation|amod|END_ENTITY	Thyrotropin-releasing_hormone stimulation of prolactin release from clonal rat pituitary cells : evidence for action independent of extracellular calcium .
6796963	0	prolactin	97,106	Thyrotropin-releasing_hormone	0,29	prolactin	Thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	transcript|compound|START_ENTITY production|nmod|transcript increase|dobj|production exerts|advcl|increase exerts|nsubj|END_ENTITY	Thyrotropin-releasing_hormone exerts rapid nuclear effects to increase production of the primary prolactin mRNA transcript .
8386115	0	prolactin	71,80	Thyrotropin-releasing_hormone	0,29	prolactin	Thyrotropin-releasing hormone	5617	7200	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Thyrotropin-releasing_hormone and epidermal_growth_factor induce human prolactin expression via identical multiple cis elements .
10595400	0	prolactin	46,55	Transforming_growth_factor-beta1	0,32	prolactin	Transforming growth factor-beta1	24683(Tax:10116)	59086(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta1 inhibits rat prolactin promoter activity in GH4 neuroendocrine cells .
9106266	0	prolactin	43,52	Transforming_growth_factor-beta_1	0,33	prolactin	Transforming growth factor-beta 1	24683(Tax:10116)	59086(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits prolactin secretion and lactotropic cell proliferation in the pituitary of oestrogen-treated Fischer 344 rats .
16254029	0	prolactin	48,57	Tumor_necrosis_factor-alpha	0,27	prolactin	Tumor necrosis factor-alpha	5617	7124	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha activates the human prolactin gene promoter via nuclear factor-kappaB signaling .
8032686	0	prolactin	56,65	Vasoactive_intestinal_polypeptide	0,33	prolactin	Vasoactive intestinal polypeptide	24683(Tax:10116)	117064(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY affects|dobj|mRNA affects|nsubj|antiserum antiserum|compound|END_ENTITY	Vasoactive_intestinal_polypeptide antiserum affects rat prolactin mRNA in 40-day but not 110-day diethylstilbestrol-induced prolactinoma tissue .
11266514	0	prolactin	59,68	activator_protein_1	92,111	prolactin	activator protein 1	5617	3725	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Identification of a decidua-specific enhancer on the human prolactin gene with two critical activator_protein_1 -LRB- AP-1 -RRB- binding sites .
7099389	0	prolactin	82,91	alpha-melanocyte-stimulating_hormone	10,46	prolactin	alpha-melanocyte-stimulating hormone	24683(Tax:10116)	24664(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Effect of alpha-melanocyte-stimulating_hormone on basal and stimulated release of prolactin : evidence for dopaminergic mediation .
11888852	0	prolactin	42,51	angiotensin_II	12,26	prolactin	angiotensin II	24683(Tax:10116)	24179(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|amod|END_ENTITY	Evidence of angiotensin_II involvement in prolactin secretion in response to hemorrhage in adrenodemedullated and guanethidine-treated rats .
1386737	0	prolactin	30,39	annexin_V	15,24	prolactin	annexin V	24683(Tax:10116)	25673(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of annexin_V with prolactin in the rat anterior pituitary gland .
2869031	0	prolactin	172,181	cAMP-dependent_vasoactive_intestinal_peptide	65,109	prolactin	cAMP-dependent vasoactive intestinal peptide	24683(Tax:10116)	117064(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent_vasoactive_intestinal_peptide and cAMP-independent thyrotropin_releasing_hormone-stimulated prolactin secretion of GH3 cells .
8592642	0	prolactin	78,87	corticotropin-releasing_factor	19,49	prolactin	corticotropin-releasing factor	24683(Tax:10116)	81648(Tax:10116)	Gene	Gene	release|compound|START_ENTITY role|nmod|release role|nmod|END_ENTITY	Permissive role of corticotropin-releasing_factor in the acute stress-induced prolactin release in female rats .
1907563	0	prolactin	14,23	endothelin-3	37,49	prolactin	endothelin-3	24683(Tax:10116)	366270(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Inhibition of prolactin secretion by endothelin-3 is pertussis toxin-sensitive .
7068102	0	prolactin	39,48	enkephalin	25,35	prolactin	enkephalin	24683(Tax:10116)	29237(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY effect|nmod|levels effect|nmod|END_ENTITY	The effect of methionine enkephalin on prolactin and luteinizing hormone levels in intact and castrated rats .
6328483	0	prolactin	157,166	epidermal_growth_factor	101,124	prolactin	epidermal growth factor	24683(Tax:10116)	25313(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Polypeptide hormone regulation of gene transcription : specific 5 ' genomic sequences are required for epidermal_growth_factor and phorbol_ester regulation of prolactin gene expression .
10632421	0	prolactin	10,19	follicle-stimulating_hormone_receptor	23,60	prolactin	follicle-stimulating hormone receptor	5617	2492	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|amod|END_ENTITY	Effect of prolactin on follicle-stimulating_hormone_receptor binding and progesterone production in cultured porcine granulosa cells .
6828449	0	prolactin	14,23	gastrin_releasing_peptide	37,62	prolactin	gastrin releasing peptide	24683(Tax:10116)	171101(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Inhibition of prolactin secretion by gastrin_releasing_peptide -LRB- GRP -RRB- in the rat .
9426156	0	prolactin	47,56	glucocorticoid_receptor	4,27	prolactin	glucocorticoid receptor	5617	2908	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	The glucocorticoid_receptor inhibits the human prolactin gene expression by interference with Pit-1 activity .
16444392	0	prolactin	11,20	gonadotropin-releasing_hormone	55,85	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	Pattern|nmod|START_ENTITY secretion|nsubj|Pattern secretion|nmod|administration administration|nmod|agonist agonist|amod|END_ENTITY	Pattern of prolactin secretion after administration of gonadotropin-releasing_hormone agonist at the preovulatory phase of intrauterine insemination cycles .
1901042	0	prolactin	6,15	gonadotropin-releasing_hormone	50,80	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	levels|compound|START_ENTITY treated|nsubj|levels treated|nmod|analogue analogue|amod|END_ENTITY	Serum prolactin levels in patients treated with a gonadotropin-releasing_hormone analogue for adenocarcinoma_of_the_prostate .
2114008	0	prolactin	21,30	gonadotropin-releasing_hormone	43,73	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Periovulatory plasma prolactin response to gonadotropin-releasing_hormone : role of endogenous opiates .
3087788	0	prolactin	20,29	gonadotropin-releasing_hormone	43,73	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of human prolactin secretion by gonadotropin-releasing_hormone in vitro .
3114203	0	prolactin	44,53	gonadotropin-releasing_hormone	10,40	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of gonadotropin-releasing_hormone on prolactin levels in males unrelated to stress or behavioral changes .
3147927	0	prolactin	69,78	gonadotropin-releasing_hormone	35,65	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Effect of exogenous and endogenous gonadotropin-releasing_hormone on prolactin secretion in perimenopausal women .
356613	0	prolactin	22,31	gonadotropin-releasing_hormone	117,147	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	levels|compound|START_ENTITY levels|nmod|hormone hormone|nmod|END_ENTITY	The effect of varying prolactin levels on pituitary luteinizing hormone and follicle-stimulating hormone response to gonadotropin-releasing_hormone .
6813347	0	prolactin	26,35	gonadotropin-releasing_hormone	48,78	prolactin	gonadotropin-releasing hormone	5617	2796	Gene	Gene	response|compound|START_ENTITY response|dep|END_ENTITY	Estrogen-dependent plasma prolactin response to gonadotropin-releasing_hormone in intact and castrated men .
8108395	0	prolactin	111,120	gonadotropin_hormone-releasing_hormone	14,52	prolactin	gonadotropin hormone-releasing hormone	5617	25194(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY neuronal|nmod|receptors neuronal|nsubj|Inhibition Inhibition|nmod|release release|amod|END_ENTITY	Inhibition of gonadotropin_hormone-releasing_hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors .
8108395	0	prolactin	64,73	gonadotropin_hormone-releasing_hormone	14,52	prolactin	gonadotropin hormone-releasing hormone	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Inhibition of gonadotropin_hormone-releasing_hormone release by prolactin from GT1 neuronal cell lines through prolactin receptors .
9022262	0	prolactin	104,113	granulocyte-macrophage_colony_stimulating_factor	10,58	prolactin	granulocyte-macrophage colony stimulating factor	24683(Tax:10116)	116630(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of granulocyte-macrophage_colony_stimulating_factor and granulocyte_colony_stimulating_factor on prolactin and adrenocorticotropic hormone secretion in rats : dose - and time-response in vivo studies .
10900161	0	prolactin	72,81	growth_hormone	83,97	prolactin	growth hormone	19109(Tax:10090)	14599(Tax:10090)	Gene	Gene	insulin-like_growth_factor-I|compound|START_ENTITY insulin-like_growth_factor-I|dep|END_ENTITY	Humoral and cell-mediated immunity in mice with genetic_deficiencies of prolactin , growth_hormone , insulin-like_growth_factor-I , and thyroid hormone .
12668880	0	prolactin	20,29	growth_hormone	32,46	prolactin	growth hormone	19109(Tax:10090)	14599(Tax:10090)	Gene	Gene	Body|nmod|START_ENTITY Ames|dep|Body Ames|amod|END_ENTITY	Body composition of prolactin - , growth_hormone , and thyrotropin-deficient Ames dwarf mice .
1428057	0	prolactin	48,57	growth_hormone	31,45	prolactin	growth hormone	5617	2688	Gene	Gene	pituitary_adenomas|compound|START_ENTITY pituitary_adenomas|compound|END_ENTITY	Ultrastructural study of mixed growth_hormone _ prolactin secreting pituitary_adenomas .
18063946	0	prolactin	21,30	growth_hormone	58,72	prolactin	growth hormone	5617	2688	Gene	Gene	pattern|nmod|START_ENTITY secretion|nsubj|pattern secretion|nmod|deficiency deficiency|amod|END_ENTITY	Circadian pattern of prolactin secretion in children with growth_hormone deficiency and congenital_organic_lesions in the hypothalamic-pituitary region .
18367632	0	prolactin	38,47	growth_hormone	89,103	prolactin	growth hormone	5617	2688	Gene	Gene	mechanism|amod|START_ENTITY Effects|nmod|mechanism Effects|nmod|mice mice|compound|END_ENTITY	Effects of every-other-day feeding on prolactin regulatory mechanism in transgenic human growth_hormone mice .
2004940	0	prolactin	69,78	growth_hormone	24,38	prolactin	growth hormone	5617	2688	Gene	Gene	irradiation|dep|START_ENTITY irradiation|nmod|adenomas adenomas|amod|producing producing|dep|END_ENTITY	External irradiation of growth_hormone producing pituitary adenomas : prolactin as a marker of hypothalamic and pituitary effects .
20138183	0	prolactin	91,100	growth_hormone	102,116	prolactin	growth hormone	100534523	100534452	Gene	Gene	START_ENTITY|appos|expression expression|amod|END_ENTITY	Acute salinity challenges in Mozambique and Nile_tilapia : differential responses of plasma prolactin , growth_hormone and branchial expression of ion transporters .
24959807	0	prolactin	31,40	growth_hormone	76,90	prolactin	growth hormone	5617	2688	Gene	Gene	rhythm|nmod|START_ENTITY Changes|nmod|rhythm dependent|nsubj|Changes dependent|nmod|secretion secretion|amod|END_ENTITY	Changes in circadian rhythm of prolactin in short children are dependent on growth_hormone secretion .
2676483	0	prolactin	10,19	growth_hormone	27,41	prolactin	growth hormone	24683(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of prolactin versus growth_hormone on islet function and the importance of using homologous mammosomatotropic hormones .
2909523	1	prolactin	178,187	growth_hormone	163,177	prolactin	growth hormone	5617	2688	Gene	Gene	family|compound|START_ENTITY family|amod|END_ENTITY	Flounder growth_hormone deduced from the cDNA sequence has the minimal size in the growth_hormone prolactin gene family .
2909523	1	prolactin	178,187	growth_hormone	89,103	prolactin	growth hormone	5617	2688	Gene	Gene	family|compound|START_ENTITY size|nmod|family has|dobj|size has|nsubj|END_ENTITY	Flounder growth_hormone deduced from the cDNA sequence has the minimal size in the growth_hormone prolactin gene family .
2969772	0	prolactin	17,26	growth_hormone	28,42	prolactin	growth hormone	5617	2688	Gene	Gene	cortisol|appos|START_ENTITY END_ENTITY|nsubj|cortisol	Plasma cortisol , prolactin , growth_hormone , and immunoreactive beta-endorphin response to fenfluramine challenge in depressed patients .
343464	0	prolactin	53,62	growth_hormone	37,51	prolactin	growth hormone	5617	2688	Gene	Gene	Variation|appos|START_ENTITY Variation|amod|END_ENTITY	Variation of blood glucose and serum growth_hormone , prolactin and insulin in subjects with insulin-dependent_diabetes , after OGTT and pretreatment with 2-Br-alpha-ergocryptine .
564386	0	prolactin	165,174	growth_hormone	11,25	prolactin	growth hormone	100861193	102171600	Gene	Gene	stimuli|nmod|START_ENTITY Release|appos|stimuli Release|nmod|END_ENTITY	Release of growth_hormone in lactating and non-lactating goats in relation to behaviour , stages of sleep , electroencephalograms , environmental stimuli and levels of prolactin , insulin , glucose and free fatty_acids in the circulation .
6310918	0	prolactin	12,21	growth_hormone	67,81	prolactin	growth hormone	5617	2688	Gene	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|amod|END_ENTITY	The role of prolactin in the inhibitory action of bromocriptine on growth_hormone secretion in acromegaly .
6310921	0	prolactin	34,43	growth_hormone	45,59	prolactin	growth hormone	24683(Tax:10116)	81668(Tax:10116)	Gene	Gene	trifluoperazine|nmod|START_ENTITY Effects|nmod|trifluoperazine thyroid|nsubj|Effects thyroid|advmod|END_ENTITY	Effects of trifluoperazine on rat prolactin , growth_hormone , thyroid stimulating hormone and adrenocorticotrophin secretion in vitro .
6424103	0	prolactin	60,69	growth_hormone	126,140	prolactin	growth hormone	5617	2688	Gene	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nmod|deficiency deficiency|compound|END_ENTITY	Synthetic hpGRF 1-40 stimulates growth_hormone and inhibits prolactin secretion in normal children and children with isolated growth_hormone deficiency .
6424103	0	prolactin	60,69	growth_hormone	32,46	prolactin	growth hormone	5617	2688	Gene	Gene	secretion|compound|START_ENTITY secretion|compound|END_ENTITY	Synthetic hpGRF 1-40 stimulates growth_hormone and inhibits prolactin secretion in normal children and children with isolated growth_hormone deficiency .
6807686	0	prolactin	20,29	growth_hormone	80,94	prolactin	growth hormone	5617	2688	Gene	Gene	levels|compound|START_ENTITY levels|nmod|prediction prediction|nmod|responsiveness responsiveness|nmod|END_ENTITY	The value of plasma prolactin levels in the prediction of the responsiveness of growth_hormone secretion to bromocriptine and TRH in acromegaly .
7002371	0	prolactin	4,13	growth_hormone	44,58	prolactin	growth hormone	5617	2688	Gene	Gene	response|compound|START_ENTITY response|acl|metoclopramide metoclopramide|nmod|END_ENTITY	The prolactin response to metoclopramide in growth_hormone deficient adolescent males .
7178369	0	prolactin	113,122	growth_hormone	54,68	prolactin	growth hormone	5617	2688	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|amod|phentolamine phentolamine|nmod|END_ENTITY	Inhibitory effect of phentolamine on diazepam-induced growth_hormone secretion and lack of effect of diazepam on prolactin secretion in man .
8055814	0	prolactin	85,94	growth_hormone	13,27	prolactin	growth hormone	5617	2688	Gene	Gene	levels|compound|START_ENTITY value|nmod|levels value|amod|END_ENTITY	-LSB- Response of growth_hormone to sandostatin and bromocriptine and prognostic value of prolactin levels in serum and thyroliberin test in patients with active acromegaly -RSB- .
8257923	0	prolactin	32,41	growth_hormone	43,57	prolactin	growth hormone	5617	2688	Gene	Gene	cannabidiol|nmod|START_ENTITY cannabidiol|amod|END_ENTITY	Effect of cannabidiol on plasma prolactin , growth_hormone and cortisol in human volunteers .
8416024	0	prolactin	106,115	growth_hormone	90,104	prolactin	growth hormone	5617	2688	Gene	Gene	hormone|dep|START_ENTITY hormone|dep|END_ENTITY	Influence of partial_sleep_deprivation on the secretion of thyrotropin , thyroid hormones , growth_hormone , prolactin , luteinizing hormone , follicle stimulating hormone , and estradiol in healthy young women .
8451535	0	prolactin	47,56	growth_hormone	31,45	prolactin	growth hormone	5617	2688	Gene	Gene	triiodothyronine|dep|START_ENTITY triiodothyronine|compound|END_ENTITY	Running-induced alterations in growth_hormone , prolactin , triiodothyronine , and thyroxine concentrations in trained and untrained men and women .
9062871	0	prolactin	34,43	growth_hormone	45,59	prolactin	growth hormone	24683(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|appos|levels levels|amod|END_ENTITY	Twenty-four hour rhythms of serum prolactin , growth_hormone and luteinizing hormone levels , and of medial basal hypothalamic corticotropin-releasing_hormone levels and dopamine and serotonin metabolism in rats neonatally administered melatonin .
7659094	0	prolactin	82,91	interferon_regulatory_factor-1	43,73	prolactin	interferon regulatory factor-1	5617	3659	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Biphasic transcriptional regulation of the interferon_regulatory_factor-1 gene by prolactin : involvement of gamma-interferon-activated sequence and Stat-related proteins .
21945780	0	prolactin	20,29	interleukin-6	33,46	prolactin	interleukin-6	5617	3569	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	-LSB- Influence of serum prolactin on interleukin-6 secretion by peripheral blood mononuclear cells in patients with systemic_lupus_erythematosus -RSB- .
1407372	0	prolactin	15,24	luteinizing_hormone-releasing_hormone	57,94	prolactin	luteinizing hormone-releasing hormone	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|pituitary pituitary|nmod|END_ENTITY	Stimulation of prolactin secretion from rat pituitary by luteinizing_hormone-releasing_hormone : evidence against mediation by angiotensin_II acting through a -LRB- Sar1-Ala8 -RRB- - angiotensin_II-sensitive receptor .
19210377	0	prolactin	89,98	luteinizing_hormone-releasing_hormone	110,147	prolactin	luteinizing hormone-releasing hormone	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	responsiveness|nmod|START_ENTITY Effects|nmod|responsiveness release|nsubj|Effects release|xcomp|END_ENTITY	Effects of estrogen and ectopic pituitary transplants on the responsiveness of pituitary prolactin release to luteinizing_hormone-releasing_hormone and dopamine .
2205478	0	prolactin	13,22	luteinizing_hormone-releasing_hormone	49,86	prolactin	luteinizing hormone-releasing hormone	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|release release|nmod|END_ENTITY	Hypothalamic prolactin stimulates the release of luteinizing_hormone-releasing_hormone from male rat hypothalamus .
2893378	0	prolactin	14,23	luteinizing_hormone-releasing_hormone	145,182	prolactin	luteinizing hormone-releasing hormone	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	Receptors|nmod|START_ENTITY Receptors|nmod|analogs analogs|nmod|END_ENTITY	Receptors for prolactin , somatostatin , and luteinizing_hormone-releasing_hormone in experimental prostate_cancer after treatment with analogs of luteinizing_hormone-releasing_hormone and somatostatin .
3116573	0	prolactin	15,24	luteinizing_hormone-releasing_hormone	38,75	prolactin	luteinizing hormone-releasing hormone	5617	2796	Gene	Gene	responses|compound|START_ENTITY responses|nmod|END_ENTITY	Abnormal serum prolactin responses to luteinizing_hormone-releasing_hormone -LRB- LHRH -RRB- in patients with anorexia_nervosa and bulimia .
8633105	0	prolactin	62,71	luteinizing_hormone-releasing_hormone	11,48	prolactin	luteinizing hormone-releasing hormone	24683(Tax:10116)	25194(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of luteinizing_hormone-releasing_hormone on pulsatile prolactin secretion in adult hyperprolactinemic female rats .
1905310	0	prolactin	8,17	luteinizing_hormone_releasing_hormone	40,77	prolactin	luteinizing hormone releasing hormone	5617	2796	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nsubj|response	Blunted prolactin response to exogenous luteinizing_hormone_releasing_hormone in superovulated women .
3745570	0	prolactin	90,99	milk	103,107	prolactin	milk	280901(Tax:9913)	100532204	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of dry period versus continuous milking on periparturient concentrations of bovine prolactin in milk from half udders .
2572126	0	prolactin	33,42	neurophysin-II	7,21	prolactin	neurophysin-II	24683(Tax:10116)	280728(Tax:9913)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Bovine neurophysin-II stimulates prolactin release without involvement of dopaminergic prolactin-release inhibiting factor receptor in the estradiol-primed male rat .
1482216	0	prolactin	16,25	ornithine_decarboxylase	29,52	prolactin	ornithine decarboxylase	24683(Tax:10116)	24609(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Acute effect of prolactin on ornithine_decarboxylase activity in the rat testis .
6145646	0	prolactin	22,31	ornithine_decarboxylase	45,68	prolactin	ornithine decarboxylase	24683(Tax:10116)	24609(Tax:10116)	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Cyclosporine inhibits prolactin induction of ornithine_decarboxylase in rat tissues .
6195664	0	prolactin	109,118	ornithine_decarboxylase	29,52	prolactin	ornithine decarboxylase	5617	4953	Gene	Gene	actions|nmod|START_ENTITY essential|nmod|actions essential|nsubj|action action|nmod|prolactin prolactin|nmod|activity activity|amod|END_ENTITY	Early action of prolactin on ornithine_decarboxylase activity is not essential for the subsequent actions of prolactin on casein and lipid biosynthesis .
6195664	0	prolactin	16,25	ornithine_decarboxylase	29,52	prolactin	ornithine decarboxylase	5617	4953	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Early action of prolactin on ornithine_decarboxylase activity is not essential for the subsequent actions of prolactin on casein and lipid biosynthesis .
8355506	0	prolactin	169,178	ornithine_decarboxylase	88,111	prolactin	ornithine decarboxylase	5617	4953	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Human promyelocytic cell line HL60 has the specific binding sites for prolactin and its ornithine_decarboxylase , DNA synthesis and cellular proliferation are induced by prolactin .
233660	0	prolactin	40,49	parathyroid_hormone	10,29	prolactin	parathyroid hormone	5617	5741	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on plasma prolactin in man .
7588268	0	prolactin	39,48	pim-1	19,24	prolactin	pim-1	24683(Tax:10116)	24649(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2_lymphoma cells .
12234101	0	prolactin	14,23	prolactin	74,83	prolactin	prolactin	19109(Tax:10090)	19109(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY Expression|nmod|receptors Expression|nmod|END_ENTITY	Expression of prolactin receptors and regulation of cell proliferation by prolactin , corticotropin-releasing_factor , and corticosterone in a neuroblastoma cell line .
12234101	0	prolactin	74,83	prolactin	14,23	prolactin	prolactin	19109(Tax:10090)	19109(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|receptors receptors|amod|END_ENTITY	Expression of prolactin receptors and regulation of cell proliferation by prolactin , corticotropin-releasing_factor , and corticosterone in a neuroblastoma cell line .
19675522	0	prolactin	51,60	prolactin	69,78	prolactin	prolactin	396965(Tax:9823)	396965(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|expression expression|compound|END_ENTITY	Effect of the polymorphism in 5 ' UTR region of pig prolactin gene on prolactin gene expression and reproduction performance in the female pig .
19675522	0	prolactin	69,78	prolactin	51,60	prolactin	prolactin	396965(Tax:9823)	396965(Tax:9823)	Gene	Gene	expression|compound|START_ENTITY gene|nmod|expression gene|compound|END_ENTITY	Effect of the polymorphism in 5 ' UTR region of pig prolactin gene on prolactin gene expression and reproduction performance in the female pig .
2982676	0	prolactin	13,22	prolactin	36,45	prolactin	prolactin	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|nmod|END_ENTITY	Induction of prolactin receptors by prolactin in the rat lung and liver : demonstration of separate receptor and antibody entities .
2982676	0	prolactin	36,45	prolactin	13,22	prolactin	prolactin	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	receptors|nmod|START_ENTITY receptors|compound|END_ENTITY	Induction of prolactin receptors by prolactin in the rat lung and liver : demonstration of separate receptor and antibody entities .
6694987	0	prolactin	24,33	prolactin	90,99	prolactin	prolactin	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Autofeedback effects of prolactin on basal , suckling-induced , and proestrous secretion of prolactin .
6694987	0	prolactin	90,99	prolactin	24,33	prolactin	prolactin	24683(Tax:10116)	24683(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Autofeedback effects of prolactin on basal , suckling-induced , and proestrous secretion of prolactin .
8930531	0	prolactin	38,47	prolactin	80,89	prolactin	prolactin	5617	5617	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Synthesis and release of glycosylated prolactin in transfected cells with human prolactin complementary deoxyribonucleic acid .
8930531	0	prolactin	80,89	prolactin	38,47	prolactin	prolactin	5617	5617	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Synthesis and release of glycosylated prolactin in transfected cells with human prolactin complementary deoxyribonucleic acid .
11051045	0	prolactin	42,51	prolactin_receptor	117,135	prolactin	prolactin receptor	5617	5618	Gene	Gene	levels|compound|START_ENTITY effects|nmod|levels effects|dep|evidence evidence|nmod|END_ENTITY	Structural and functional effects of high prolactin levels on injured endothelial cells : evidence for an endothelial prolactin_receptor .
15040892	0	prolactin	49,58	prolactin_receptor	14,32	prolactin	prolactin receptor	5617	5618	Gene	Gene	stimulation|compound|START_ENTITY Expression|nmod|stimulation Expression|nmod|END_ENTITY	Expression of prolactin_receptor and response to prolactin stimulation of human NK cell lines .
1595899	0	prolactin	29,38	prolactin_receptor	89,107	prolactin	prolactin receptor	100009394(Tax:9986)	100009046(Tax:9986)	Gene	Gene	START_ENTITY|xcomp|using using|dobj|END_ENTITY	Radioreceptor assay of serum prolactin using nitrocellulose membrane-immobilized mammary prolactin_receptor .
18407079	0	prolactin	74,83	prolactin_receptor	23,41	prolactin	prolactin receptor	5617	5618	Gene	Gene	action|compound|START_ENTITY mechanism|nmod|action insights|nmod|mechanism forms|dep|insights forms|nmod|END_ENTITY	Different forms of the prolactin_receptor : insights into the mechanism of prolactin action .
18765257	0	prolactin	12,21	prolactin_receptor	28,46	prolactin	prolactin receptor	24683(Tax:10116)	24684(Tax:10116)	Gene	Gene	Circulating|dobj|START_ENTITY END_ENTITY|advcl|Circulating	Circulating prolactin , MPOA prolactin_receptor expression and maternal_aggression in lactating rats .
1953642	0	prolactin	38,47	prolactin_receptor	78,96	prolactin	prolactin receptor	100009394(Tax:9986)	100009046(Tax:9986)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hormones on dissociation of prolactin from the rabbit mammary gland prolactin_receptor .
21068074	0	prolactin	108,117	prolactin_receptor	4,22	prolactin	prolactin receptor	5617	5618	Gene	Gene	role|nmod|START_ENTITY macrophages|dep|role expressed|nmod|macrophages expressed|nsubjpass|END_ENTITY	The prolactin_receptor is expressed in macrophages within human carotid atherosclerotic_plaques : a role for prolactin in atherogenesis ?
24735798	0	prolactin	162,171	prolactin_receptor	58,76	prolactin	prolactin receptor	5617	5618	Gene	Gene	induced|nmod|START_ENTITY Impact|acl|induced Impact|nmod|END_ENTITY	Impact of subdomain D1 of the short form S1b of the human prolactin_receptor on its inhibitory action on the function of the long form of the receptor induced by prolactin .
2620666	0	prolactin	20,29	prolactin_receptor	49,67	prolactin	prolactin receptor	100009394(Tax:9986)	100009046(Tax:9986)	Gene	Gene	Interaction|nmod|START_ENTITY END_ENTITY|nsubj|Interaction	Interaction between prolactin and rabbit mammary prolactin_receptor in the presence of environment-modifying agents .
2701177	0	prolactin	91,100	prolactin_receptor	45,63	prolactin	prolactin receptor	5617	5618	Gene	Gene	fragments|compound|START_ENTITY identification|nmod|fragments digestion|dep|identification digestion|nmod|END_ENTITY	Partial proteolytic digestion of the mammary prolactin_receptor : identification of smaller prolactin binding fragments .
2966772	0	prolactin	69,78	prolactin_receptor	12,30	prolactin	prolactin receptor	24683(Tax:10116)	24684(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY increase|nmod|levels content|nmod|increase END_ENTITY|dobj|content	High tumour prolactin_receptor content and lack of increase in serum prolactin levels as predictors of good response to endocrine therapy in rat mammary cancer .
6295905	0	prolactin	38,47	prolactin_receptor	66,84	prolactin	prolactin receptor	24683(Tax:10116)	24684(Tax:10116)	Gene	Gene	START_ENTITY|nmod|methods methods|compound|END_ENTITY	Characterization of -LSB- 125I -RSB- - iodo-ovine prolactin and evaluation of prolactin_receptor assay methods .
7664695	0	prolactin	133,142	prolactin_receptor	14,32	prolactin	prolactin receptor	24683(Tax:10116)	24684(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of prolactin_receptor mRNA expression in peripheral lymphocytes in rats in response to changes in serum concentrations of prolactin .
8206330	0	prolactin	31,40	prolactin_receptor	113,131	prolactin	prolactin receptor	100750601	100757415	Gene	Gene	Endocytosis|nmod|START_ENTITY transfected|nsubj|Endocytosis transfected|nmod|cDNA cDNA|compound|END_ENTITY	Endocytosis and degradation of prolactin and its receptor in Chinese_hamster_ovary cells stably transfected with prolactin_receptor cDNA .
17360981	0	prolactin	79,88	pyruvate_dehydrogenase_kinase_4	33,64	prolactin	pyruvate dehydrogenase kinase 4	19109(Tax:10090)	27273(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	The STAT5A-mediated induction of pyruvate_dehydrogenase_kinase_4 expression by prolactin or growth_hormone in adipocytes .
18321529	0	prolactin	47,56	serotonin_transporter	20,41	prolactin	serotonin transporter	5617	6532	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nmod|response	Relationship of the serotonin_transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence .
15996754	0	prolactin	116,125	serum_amyloid_A3	48,64	prolactin	serum amyloid A3	280901(Tax:9913)	281474(Tax:9913)	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|expression expression|nmod|END_ENTITY	Differential expression and secretion of bovine serum_amyloid_A3 -LRB- SAA3 -RRB- by mammary epithelial cells stimulated with prolactin or lipopolysaccharide .
217513	0	prolactin	16,25	somatomedin	35,46	prolactin	somatomedin	24683(Tax:10116)	24482(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of ovine prolactin on serum somatomedin bioactivity in hypophysectomized female rats .
3918138	0	prolactin	87,96	thyrotrophin-releasing_hormone	24,54	prolactin	thyrotrophin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	concentrations|nmod|START_ENTITY END_ENTITY|nmod|concentrations	Effects of antiserum to thyrotrophin-releasing_hormone on the concentrations of plasma prolactin , thyrotrophin and LH in the pro-oestrous rat .
6784427	0	prolactin	6,15	thyrotrophin-releasing_hormone	46,76	prolactin	thyrotrophin-releasing hormone	5617	7200	Gene	Gene	responses|compound|START_ENTITY Serum|dobj|responses Serum|xcomp|END_ENTITY	Serum prolactin and thyrotrophin responses to thyrotrophin-releasing_hormone at different times of the day in normal women .
10406461	0	prolactin	123,132	thyrotropin-releasing_hormone	76,105	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	promoter|compound|START_ENTITY stimulate|dobj|promoter mediating|advcl|stimulate mediating|dobj|ability ability|nmod|END_ENTITY	A role for the mitogen-activated protein kinase in mediating the ability of thyrotropin-releasing_hormone to stimulate the prolactin promoter .
177274	0	prolactin	91,100	thyrotropin-releasing_hormone	58,87	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|compound|START_ENTITY role|nmod|release role|nmod|END_ENTITY	A possible role of cyclic_AMP in mediating the effects of thyrotropin-releasing_hormone on prolactin release and on prolactin and growth_hormone synthesis in pituitary cells in culture .
1899114	0	prolactin	19,28	thyrotropin-releasing_hormone	50,79	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|acl|induced induced|nmod|potassium potassium|amod|END_ENTITY	Quinidine inhibits prolactin secretion induced by thyrotropin-releasing_hormone , high medium potassium or hyposmolarity in GH4C1 cells .
1908099	0	prolactin	22,31	thyrotropin-releasing_hormone	113,142	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	diethylstilbestrol-treated|nmod|START_ENTITY diethylstilbestrol-treated|nmod|administration administration|amod|END_ENTITY	Bioactivity of plasma prolactin in ovariectomized , diethylstilbestrol-treated Long-Evans and Holtzman rats after thyrotropin-releasing_hormone or bromocriptine administration .
1909855	0	prolactin	12,21	thyrotropin-releasing_hormone	34,63	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY Exaggerated|dobj|response Exaggerated|xcomp|END_ENTITY	Exaggerated prolactin response to thyrotropin-releasing_hormone in infertile women with the luteinized unruptured_follicle_syndrome .
19289102	0	prolactin	126,135	thyrotropin-releasing_hormone	82,111	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression involvement|acl|induced involvement|nmod|MKP-1 MKP-1|nmod|END_ENTITY	Possible involvement of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced prolactin gene expression .
1947441	0	prolactin	15,24	thyrotropin-releasing_hormone	37,66	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- throughout the proliferative phases in the ovulatory and anovulatory menstrual cycle .
20960102	0	prolactin	79,88	thyrotropin-releasing_hormone	114,143	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY transcription|acl|induced induced|nmod|END_ENTITY	The transcription factor prolactin_regulatory_element-binding_protein mediates prolactin transcription induced by thyrotropin-releasing_hormone in GH3 cells .
2446857	0	prolactin	50,59	thyrotropin-releasing_hormone	82,111	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene calcium|nmod|regulation role|nmod|calcium transcription|nsubj|role transcription|nmod|END_ENTITY	Preferential role of calcium in the regulation of prolactin gene transcription by thyrotropin-releasing_hormone in GH3 pituitary cells .
2492223	0	prolactin	131,140	thyrotropin-releasing_hormone	37,66	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	levels|compound|START_ENTITY significance|nmod|levels Factors|dep|significance Factors|acl|influencing influencing|dobj|effectiveness effectiveness|nmod|therapy therapy|amod|END_ENTITY	Factors influencing effectiveness of thyrotropin-releasing_hormone therapy for severe epilepsy in childhood : significance of serum prolactin levels .
2501668	0	prolactin	104,113	thyrotropin-releasing_hormone	27,56	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY cause|dobj|release ability|acl|cause lose|dobj|ability lose|nsubj|transients transients|acl|induced induced|nmod|END_ENTITY	Ca2 + transients induced by thyrotropin-releasing_hormone rapidly lose their ability to cause release of prolactin .
3086358	0	prolactin	48,57	thyrotropin-releasing_hormone	76,105	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY inhibits|dobj|response inhibits|nmod|END_ENTITY	Carbidopa plus L-dopa pretreatment inhibits the prolactin -LRB- PRL -RRB- response to thyrotropin-releasing_hormone and thus can not distinguish central from pituitary sites of prolactin stimulation .
3090397	0	prolactin	127,136	thyrotropin-releasing_hormone	76,105	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|compound|START_ENTITY induced|dobj|release induced|nsubj|comparison comparison|nmod|effects effects|nmod|antagonism antagonism|nmod|END_ENTITY	A comparison of the effects of suckling or transient dopamine antagonism on thyrotropin-releasing_hormone and suckling induced prolactin release in lactating rats .
3092268	0	prolactin	4,13	thyrotropin-releasing_hormone	26,55	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY END_ENTITY|nsubj|response	The prolactin response to thyrotropin-releasing_hormone in depressed patients and normal subjects .
3118231	0	prolactin	62,71	thyrotropin-releasing_hormone	21,50	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|compound|START_ENTITY actions|nmod|release actions|amod|END_ENTITY	Bradykinin parallels thyrotropin-releasing_hormone actions on prolactin release from rat anterior pituitary cells .
3119699	0	prolactin	10,19	thyrotropin-releasing_hormone	38,67	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	responsiveness|nsubj|START_ENTITY responsiveness|xcomp|END_ENTITY	Subnormal prolactin responsiveness to thyrotropin-releasing_hormone -LRB- TRH -RRB- in women with primary_empty_sella_syndrome .
3137402	0	prolactin	73,82	thyrotropin-releasing_hormone	101,130	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|amod|START_ENTITY response|dep|END_ENTITY	Use of a pharmacokinetic model to characterize the thyrotropin -LRB- TSH -RRB- and prolactin -LRB- PRL -RRB- response to thyrotropin-releasing_hormone -LRB- THR -RRB- in man .
3926294	1	prolactin	72,81	thyrotropin-releasing_hormone	100,129	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	Normalization|nmod|START_ENTITY responsiveness|nsubj|Normalization responsiveness|xcomp|END_ENTITY	Normalization of exaggerated prolactin responsiveness to thyrotropin-releasing_hormone .
3930485	0	prolactin	103,112	thyrotropin-releasing_hormone	39,68	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY mechanisms|nmod|transcription mechanisms|nmod|END_ENTITY	Molecular mechanisms of phorbol_ester , thyrotropin-releasing_hormone , and growth_factor stimulation of prolactin gene transcription .
3932125	0	prolactin	19,28	thyrotropin-releasing_hormone	85,114	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	START_ENTITY|nmod|ridibunda ridibunda|nmod|injection injection|nmod|END_ENTITY	In vivo release of prolactin in Rana ridibunda following an intravenous injection of thyrotropin-releasing_hormone .
3932452	0	prolactin	4,13	thyrotropin-releasing_hormone	26,55	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	The prolactin response to thyrotropin-releasing_hormone does not distinguish teenaged males with hypogonadotropic_hypogonadism from those with constitutional_delay_of_growth_and_development .
3938733	0	prolactin	24,33	thyrotropin-releasing_hormone	75,104	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	concentration|nmod|START_ENTITY concentration|nmod|infusion infusion|nmod|END_ENTITY	Plasma concentration of prolactin during four-day osmotic pump infusion of thyrotropin-releasing_hormone and vasoactive_intestinal_polypeptide in rats .
403069	0	prolactin	15,24	thyrotropin-releasing_hormone	78,107	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	Suppression|nmod|START_ENTITY secretion|nsubj|Suppression secretion|nmod|END_ENTITY	Suppression of prolactin and thyrotropin secretion in the rat by antiserum to thyrotropin-releasing_hormone .
404311	0	prolactin	15,24	thyrotropin-releasing_hormone	37,66	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- during the menstrual cycle of normal women .
410851	0	prolactin	25,34	thyrotropin-releasing_hormone	104,133	prolactin	thyrotropin-releasing hormone	280901(Tax:9913)	613414(Tax:9913)	Gene	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of bovine serum prolactin and growth hormone to duodenal , abomasal , and oral administration of thyrotropin-releasing_hormone .
4199418	0	prolactin	34,43	thyrotropin-releasing_hormone	56,85	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY inhibition|nmod|response inhibition|nmod|END_ENTITY	Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing_hormone .
4213193	0	prolactin	76,85	thyrotropin-releasing_hormone	15,44	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Interaction of thyrotropin-releasing_hormone and dopamine on the release of prolactin from the rat anterior pituitary in vitro .
4626583	0	prolactin	6,15	thyrotropin-releasing_hormone	147,176	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Human prolactin and thyrotropin concentrations in the serums of normal and hypopituitary children before and after the administration of synthetic thyrotropin-releasing_hormone .
6436062	0	prolactin	22,31	thyrotropin-releasing_hormone	55,84	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY Dissociation|nmod|response Dissociation|acl|sequential sequential|dobj|stimulation stimulation|amod|END_ENTITY	Dissociation of serum prolactin response to sequential thyrotropin-releasing_hormone and chlorpromazine stimulation in patients with primary_empty_sella_syndrome .
6436160	2	prolactin	63,72	thyrotropin-releasing_hormone	85,114	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY Restoration|nmod|response Restoration|acl|END_ENTITY	Restoration of the prolactin response to thyrotropin-releasing_hormone by low-dose dopamine infusion in women with pathological hyperprolactinemia .
6773747	0	prolactin	121,130	thyrotropin-releasing_hormone	14,43	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	Evidence|nmod|START_ENTITY Evidence|dep|function function|nsubj|END_ENTITY	Evidence that thyrotropin-releasing_hormone and a hypothalamic prolactin-releasing factor may function in the release of prolactin in the lactating rat .
6774631	1	prolactin	134,143	thyrotropin-releasing_hormone	214,243	prolactin	thyrotropin-releasing hormone	24683(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|compound|START_ENTITY Variation|nmod|content Variation|nmod|END_ENTITY	Variation in prolactin content of individual cell colonies , and dynamics of stimulation with thyrotropin-releasing_hormone -LRB- TRH -RRB- .
6778717	0	prolactin	12,21	thyrotropin-releasing_hormone	34,63	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Exaggerated prolactin response to thyrotropin-releasing_hormone and metoclopramide in primary testicular_failure .
6782838	0	prolactin	6,15	thyrotropin-releasing_hormone	45,74	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	responses|compound|START_ENTITY Serum|dobj|responses Serum|xcomp|END_ENTITY	Serum prolactin and thyrotropin responses to thyrotropin-releasing_hormone in men with alcoholic_cirrhosis .
6802681	0	prolactin	12,21	thyrotropin-releasing_hormone	34,63	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Exaggerated prolactin response of thyrotropin-releasing_hormone in women with anovulatory_cycles : possible role of endogenous estrogens and effect of bromocriptine .
6804899	0	prolactin	10,19	thyrotropin-releasing_hormone	32,61	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Increased prolactin response to thyrotropin-releasing_hormone in primary ovarian_failure .
808433	0	prolactin	7,16	thyrotropin-releasing_hormone	29,58	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	-LSB- Serum prolactin response to thyrotropin-releasing_hormone in normal subjects and in patients with thyroid_diseases -LRB- author 's transl -RRB- -RSB- .
809462	0	prolactin	77,86	thyrotropin-releasing_hormone	99,128	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY response|nmod|END_ENTITY	Effect of an oral water load on serum TSH in normal subjects , and on TSH and prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with primary_hypothyroidism .
8162388	0	prolactin	6,15	thyrotropin-releasing_hormone	28,57	prolactin	thyrotropin-releasing hormone	5617	7200	Gene	Gene	response|compound|START_ENTITY Serum|dobj|response Serum|xcomp|END_ENTITY	Serum prolactin response to thyrotropin-releasing_hormone during status_epilepticus .
20213525	0	prolactin	7,16	transferrin	50,61	prolactin	transferrin	5617	7018	Gene	Gene	promotes|nsubj|START_ENTITY promotes|dobj|expression expression|nmod|END_ENTITY	Bovine prolactin promotes the expression of human transferrin in the milk of transgenic_mice .
10770042	0	prolactin	108,117	transforming_growth_factor_beta_1	71,104	prolactin	transforming growth factor beta 1	5617	7040	Gene	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	In vitro differentiation of human endometrial stromal cells : effect of transforming_growth_factor_beta_1 on prolactin secretion .
3493951	0	prolactin	89,98	vasoactive_intestinal_polypeptide	19,52	prolactin	vasoactive intestinal polypeptide	5617	7432	Gene	Gene	secretion|compound|START_ENTITY histidine_isoleucine|nmod|secretion histidine_isoleucine|nsubj|effect effect|nmod|END_ENTITY	In vitro effect of vasoactive_intestinal_polypeptide and peptide histidine_isoleucine on prolactin secretion by the bullfrog pituitary gland .
3841194	0	prolactin	122,131	vasoactive_intestinal_polypeptide	30,63	prolactin	vasoactive intestinal polypeptide	24683(Tax:10116)	117064(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY attenuates|dobj|secretion attenuates|nsubj|Administration Administration|nmod|antisera antisera|acl|END_ENTITY	Administration of antisera to vasoactive_intestinal_polypeptide and peptide histidine_isoleucine attenuates ether-induced prolactin secretion in rats .
3872804	0	prolactin	70,79	vasoactive_intestinal_polypeptide	27,60	prolactin	vasoactive intestinal polypeptide	24683(Tax:10116)	117064(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY antiserum|nmod|secretion antiserum|acl|END_ENTITY	Inhibition by antiserum to vasoactive_intestinal_polypeptide -LRB- VIP -RRB- of prolactin secretion induced by serotonin in the rat .
4090907	0	prolactin	15,24	vasoactive_intestinal_polypeptide	60,93	prolactin	vasoactive intestinal polypeptide	5617	7432	Gene	Gene	response|compound|START_ENTITY Lack|nmod|response injected|nsubj|Lack injected|dobj|END_ENTITY	Lack of plasma prolactin response to intravenously injected vasoactive_intestinal_polypeptide in patients with prolactin-secreting adenoma .
6709640	0	prolactin	71,80	vasoactive_intestinal_polypeptide	28,61	prolactin	vasoactive intestinal polypeptide	24683(Tax:10116)	117064(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Involvement of hypothalamic vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in prolactin secretion induced by serotonin in rats .
7266772	0	prolactin	15,24	vasoactive_intestinal_polypeptide	56,89	prolactin	vasoactive intestinal polypeptide	707052(Tax:9544)	117064(Tax:10116)	Gene	Gene	Stimulation|nmod|START_ENTITY secretion|nsubj|Stimulation secretion|nmod|END_ENTITY	Stimulation of prolactin secretion in rhesus_monkeys by vasoactive_intestinal_polypeptide .
7609919	0	prolactin	149,158	vasoactive_intestinal_polypeptide	24,57	prolactin	vasoactive intestinal polypeptide	24683(Tax:10116)	117064(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY stimulating|nmod|secretion stimulating|nsubj|involvement involvement|nmod|END_ENTITY	Possible involvement of vasoactive_intestinal_polypeptide in the central stimulating action of pituitary_adenylate_cyclase-activating_polypeptide on prolactin secretion in the rat .
10406465	0	prolactin	30,39	vitamin_D_receptor	52,70	prolactin	vitamin D receptor	5617	7421	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Synergistic activation of the prolactin promoter by vitamin_D_receptor and GHF-1 : role of the coactivators , CREB-binding_protein and steroid_hormone_receptor_coactivator-1 -LRB- SRC-1 -RRB- .
10576657	0	prolactin-inducible_protein	23,50	PIP	52,55	prolactin-inducible protein	PIP	5304	5304	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The potential role for prolactin-inducible_protein -LRB- PIP -RRB- as a marker of human breast_cancer micrometastasis .
20052012	0	prolactin-inducible_protein	47,74	PIP	76,79	prolactin-inducible protein	PIP	18716(Tax:10090)	18716(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Generation and initial characterization of the prolactin-inducible_protein -LRB- PIP -RRB- null mouse : accompanying global changes in gene expression in the submandibular gland .
19854191	0	prolactin-like_protein	8,30	PRL-L	32,37	prolactin-like protein	PRL-L	417800(Tax:9031)	417800(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel prolactin-like_protein -LRB- PRL-L -RRB- gene in chickens and zebrafish : cloning and characterization of its tissue expression .
23523997	0	prolactin-like_protein	8,30	PRL-L	32,37	prolactin-like protein	PRL-L	417800(Tax:9031)	417800(Tax:9031)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of prolactin-like_protein -LRB- PRL-L -RRB- in cold-induced increase of muscle mass in chicks .
10906066	0	prolactin-like_protein_A	17,41	GATA-2	0,6	prolactin-like protein A	GATA-2	19110(Tax:10090)	14461(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY restricts|dobj|expression restricts|nsubj|END_ENTITY	GATA-2 restricts prolactin-like_protein_A expression to secondary trophoblast giant cells in the mouse .
11164105	0	prolactin-like_protein_E	7,31	thrombopoietin	54,68	prolactin-like protein E	thrombopoietin	19113(Tax:10090)	7066	Gene	Gene	synergizes|amod|START_ENTITY synergizes|nmod|END_ENTITY	Murine prolactin-like_protein_E synergizes with human thrombopoietin to stimulate expansion of human megakaryocytes and their precursors .
2343034	0	prolactin-like_proteins_A_and_B	59,90	placental_lactogen_II	29,50	prolactin-like proteins A and B	placental lactogen II	24656;24657	24283(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|localization localization|nmod|END_ENTITY	Cellular localization of rat placental_lactogen_II and rat prolactin-like_proteins_A_and_B by in situ hybridization .
15885496	0	prolactin-releasing_hormone	14,41	PRLH	43,47	prolactin-releasing hormone	PRLH	51052	51052	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Origin of the prolactin-releasing_hormone -LRB- PRLH -RRB- receptors : evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution .
14742914	0	prolactin-releasing_peptide	4,31	GPR10	42,47	prolactin-releasing peptide	GPR10	51052	226278(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	The prolactin-releasing_peptide receptor -LRB- GPR10 -RRB- regulates body weight homeostasis in mice .
10198200	0	prolactin-releasing_peptide	52,79	PrRP	81,85	prolactin-releasing peptide	PrRP	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and characterization of immunoreactive prolactin-releasing_peptide -LRB- PrRP -RRB- in rat tissue and plasma .
10501562	0	prolactin-releasing_peptide	22,49	PrRP	51,55	prolactin-releasing peptide	PrRP	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Cytochemical study of prolactin-releasing_peptide -LRB- PrRP -RRB- in the rat brain .
11186069	0	prolactin-releasing_peptide	11,38	PrRP	40,44	prolactin-releasing peptide	PrRP	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of prolactin-releasing_peptide -LRB- PrRP -RRB- on sleep regulation in rats .
15620420	0	prolactin-releasing_peptide	20,47	PrRP	49,53	prolactin-releasing peptide	PrRP	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Nicotine stimulates prolactin-releasing_peptide -LRB- PrRP -RRB- cells and non-PrRP cells in the solitary nucleus .
2123920	0	prolactin_and_TSH	20,37	growth_hormone	4,18	prolactin and TSH	growth hormone	5617	2688	Gene	Gene	response|amod|START_ENTITY response|amod|END_ENTITY	The growth_hormone , prolactin_and_TSH response to TRH and L-dopa in patients with hyperprolactinaemia and a normal-sized sella turcica may denote a pituitary_adenoma .
10433247	0	prolactin_receptor	69,87	B2036	36,41	prolactin receptor	B2036	5618	945235(Tax:511145)	Gene	Gene	interact|nmod|START_ENTITY interact|nsubj|END_ENTITY	The human growth_hormone antagonist B2036 does not interact with the prolactin_receptor .
2293027	0	prolactin_receptor	85,103	Growth_hormone	0,14	prolactin receptor	Growth hormone	24684(Tax:10116)	81668(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Growth_hormone pretranslationally regulates the sexually dimorphic expression of the prolactin_receptor gene in rat liver .
7925093	0	prolactin_receptor	68,86	JAK2	0,4	prolactin receptor	JAK2	5618	3717	Gene	Gene	dimerization|compound|START_ENTITY induced|nmod|dimerization induced|nsubj|activation activation|nummod|END_ENTITY	JAK2 activation and cell proliferation induced by antibody-mediated prolactin_receptor dimerization .
9099911	0	prolactin_receptor	82,100	JAK2	157,161	prolactin receptor	JAK2	100009046(Tax:9986)	100358134(Tax:9986)	Gene	Gene	part|nmod|START_ENTITY obligatory|nsubj|part obligatory|nmod|activation activation|compound|END_ENTITY	Prolactin signal transduction to milk protein genes : carboxy-terminal part of the prolactin_receptor and its tyrosine phosphorylation are not obligatory for JAK2 and STAT5 activation .
9202403	0	prolactin_receptor	98,116	JAK2	60,64	prolactin receptor	JAK2	5618	3717	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin_receptor .
7537736	0	prolactin_receptor	55,73	Jak2	31,35	prolactin receptor	Jak2	5618	3717	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Proline-rich sequence-mediated Jak2 association to the prolactin_receptor is required but not sufficient for signal transduction .
21793946	0	prolactin_receptor	54,72	Kisspeptin	0,10	prolactin receptor	Kisspeptin	443020(Tax:9940)	101107719	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	Kisspeptin cells in the ovine arcuate nucleus express prolactin_receptor but not melatonin receptor .
1406702	0	prolactin_receptor	16,34	Nb2	4,7	prolactin receptor	Nb2	24684(Tax:10116)	114589(Tax:10116)	Gene	Gene	form|nmod|START_ENTITY form|amod|END_ENTITY	The Nb2 form of prolactin_receptor is able to activate a milk protein gene promoter .
1718958	0	prolactin_receptor	72,90	Nb2	40,43	prolactin receptor	Nb2	24684(Tax:10116)	114589(Tax:10116)	Gene	Gene	form|nmod|START_ENTITY expresses|dobj|form expresses|nsubj|line line|appos|END_ENTITY	A prolactin-dependent immune cell line -LRB- Nb2 -RRB- expresses a mutant form of prolactin_receptor .
2394695	0	prolactin_receptor	65,83	Nb2	87,90	prolactin receptor	Nb2	24684(Tax:10116)	114589(Tax:10116)	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Mitogenic and binding properties of monoclonal antibodies to the prolactin_receptor in Nb2 rat lymphoma cells .
8987522	0	prolactin_receptor	16,34	PRL-R	36,41	prolactin receptor	PRL-R	19116(Tax:10090)	19116(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modification of prolactin_receptor -LRB- PRL-R -RRB- expression by PRL in the mouse liver : estimation of the ratio of two forms of PRL-R mRNAs by `` one-sided competitive PCR '' .
9603266	0	prolactin_receptor	49,67	PRL-R	69,74	prolactin receptor	PRL-R	5618	5618	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Developmental expression and localization of the prolactin_receptor -LRB- PRL-R -RRB- gene in ewe mammary gland during pregnancy and lactation : estimation of the ratio of the two forms of PRL-R messenger ribonucleic acid .
20349144	0	prolactin_receptor	39,57	PRLR	59,63	prolactin receptor	PRLR	281422(Tax:9913)	281422(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms of the prolactin_receptor -LRB- PRLR -RRB- gene and its association with growth traits in Chinese cattle .
21812980	0	prolactin_receptor	71,89	PRLr	91,95	prolactin receptor	PRLr	479363(Tax:9615)	479363(Tax:9615)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Luteal and placental function in the bitch : spatio-temporal changes in prolactin_receptor -LRB- PRLr -RRB- expression at dioestrus , pregnancy and normal and induced parturition .
11403105	0	prolactin_receptor	67,85	Prolactin	0,9	prolactin receptor	Prolactin	5618	5617	Gene	Gene	analysis|nmod|START_ENTITY analysis|nummod|END_ENTITY	Prolactin binding analysis and immunohistochemical localization of prolactin_receptor in porcine ovarian cells .
21775057	0	prolactin_receptor	82,100	Prolactin	0,9	prolactin receptor	Prolactin	5618	5617	Gene	Gene	type|compound|START_ENTITY importance|nmod|type survival|dep|importance increases|dobj|survival increases|nsubj|END_ENTITY	Prolactin increases survival and migration of ovarian_cancer cells : importance of prolactin_receptor type and therapeutic potential of S179D and G129R receptor antagonists .
24022869	0	prolactin_receptor	106,124	Prolactin	0,9	prolactin receptor	Prolactin	5618	5617	Gene	Gene	Contribution|nmod|START_ENTITY regulates|dobj|Contribution regulates|nsubj|END_ENTITY	Prolactin regulates TRPV1 , TRPA1 , and TRPM8 in sensory neurons in a sex-dependent manner : Contribution of prolactin_receptor to inflammatory_pain .
26567005	0	prolactin_receptor	55,73	Prolactin	0,9	prolactin receptor	Prolactin	19116(Tax:10090)	19109(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|transport transport|compound|END_ENTITY	Prolactin transport into mouse brain is independent of prolactin_receptor .
9723866	0	prolactin_receptor	127,145	Prolactin	0,9	prolactin receptor	Prolactin	100757415	100750601	Gene	Gene	expressing|dobj|START_ENTITY induces|xcomp|expressing induces|nsubj|END_ENTITY	Prolactin induces an inward current through voltage-independent Ca2 + channels in Chinese_hamster_ovary cells stably expressing prolactin_receptor .
11675469	0	prolactin_receptor	65,83	Prolactin_receptor	0,18	prolactin receptor	Prolactin receptor	5618	5618	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	Prolactin_receptor gene expression and immunolocalization of the prolactin_receptor in human luteinized granulosa cells .
12531430	0	prolactin_receptor	48,66	SHP-2	24,29	prolactin receptor	SHP-2	5618	5781	Gene	Gene	downstream|nmod|START_ENTITY downstream|compound|END_ENTITY	The adaptor function of SHP-2 downstream of the prolactin_receptor is required for the recruitment of p29 , a substrate of SHP-2 .
23499864	0	prolactin_receptor	30,48	cPRLR	50,55	prolactin receptor	cPRLR	395660(Tax:9031)	395660(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of prolactin_receptor -LRB- cPRLR -RRB- gene in chickens : gene structure , tissue expression , promoter analysis , and its interaction with chicken prolactin -LRB- cPRL -RRB- and prolactin-like_protein -LRB- cPRL-L -RRB- .
24683423	0	prolactin_receptor	96,114	growth_hormone	64,78	prolactin receptor	growth hormone	5618	2688	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|xcomp|binding	In silico investigation of pH-dependence of prolactin and human growth_hormone binding to human prolactin_receptor .
11668597	0	prolactin_receptor	49,67	progesterone_receptor	96,117	prolactin receptor	progesterone receptor	5618	5241	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Transcriptional and spatiotemporal regulation of prolactin_receptor mRNA and cooperativity with progesterone_receptor function during ductal branch growth in the mammary gland .
11051045	0	prolactin_receptor	117,135	prolactin	42,51	prolactin receptor	prolactin	5618	5617	Gene	Gene	evidence|nmod|START_ENTITY effects|dep|evidence effects|nmod|levels levels|compound|END_ENTITY	Structural and functional effects of high prolactin levels on injured endothelial cells : evidence for an endothelial prolactin_receptor .
15040892	0	prolactin_receptor	14,32	prolactin	49,58	prolactin receptor	prolactin	5618	5617	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|stimulation stimulation|compound|END_ENTITY	Expression of prolactin_receptor and response to prolactin stimulation of human NK cell lines .
1595899	0	prolactin_receptor	89,107	prolactin	29,38	prolactin receptor	prolactin	100009046(Tax:9986)	100009394(Tax:9986)	Gene	Gene	using|dobj|START_ENTITY END_ENTITY|xcomp|using	Radioreceptor assay of serum prolactin using nitrocellulose membrane-immobilized mammary prolactin_receptor .
18407079	0	prolactin_receptor	23,41	prolactin	74,83	prolactin receptor	prolactin	5618	5617	Gene	Gene	forms|nmod|START_ENTITY forms|dep|insights insights|nmod|mechanism mechanism|nmod|action action|compound|END_ENTITY	Different forms of the prolactin_receptor : insights into the mechanism of prolactin action .
18765257	0	prolactin_receptor	28,46	prolactin	12,21	prolactin receptor	prolactin	24684(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|advcl|Circulating Circulating|dobj|END_ENTITY	Circulating prolactin , MPOA prolactin_receptor expression and maternal_aggression in lactating rats .
1953642	0	prolactin_receptor	78,96	prolactin	38,47	prolactin receptor	prolactin	100009046(Tax:9986)	100009394(Tax:9986)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of hormones on dissociation of prolactin from the rabbit mammary gland prolactin_receptor .
21068074	0	prolactin_receptor	4,22	prolactin	108,117	prolactin receptor	prolactin	5618	5617	Gene	Gene	expressed|nsubjpass|START_ENTITY expressed|nmod|macrophages macrophages|dep|role role|nmod|END_ENTITY	The prolactin_receptor is expressed in macrophages within human carotid atherosclerotic_plaques : a role for prolactin in atherogenesis ?
24735798	0	prolactin_receptor	58,76	prolactin	162,171	prolactin receptor	prolactin	5618	5617	Gene	Gene	Impact|nmod|START_ENTITY Impact|acl|induced induced|nmod|END_ENTITY	Impact of subdomain D1 of the short form S1b of the human prolactin_receptor on its inhibitory action on the function of the long form of the receptor induced by prolactin .
2620666	0	prolactin_receptor	49,67	prolactin	20,29	prolactin receptor	prolactin	100009046(Tax:9986)	100009394(Tax:9986)	Gene	Gene	START_ENTITY|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction between prolactin and rabbit mammary prolactin_receptor in the presence of environment-modifying agents .
2701177	0	prolactin_receptor	45,63	prolactin	91,100	prolactin receptor	prolactin	5618	5617	Gene	Gene	digestion|nmod|START_ENTITY digestion|dep|identification identification|nmod|fragments fragments|compound|END_ENTITY	Partial proteolytic digestion of the mammary prolactin_receptor : identification of smaller prolactin binding fragments .
2966772	0	prolactin_receptor	12,30	prolactin	69,78	prolactin receptor	prolactin	24684(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|dobj|content content|nmod|increase increase|nmod|levels levels|compound|END_ENTITY	High tumour prolactin_receptor content and lack of increase in serum prolactin levels as predictors of good response to endocrine therapy in rat mammary cancer .
6295905	0	prolactin_receptor	66,84	prolactin	38,47	prolactin receptor	prolactin	24684(Tax:10116)	24683(Tax:10116)	Gene	Gene	methods|compound|START_ENTITY END_ENTITY|nmod|methods	Characterization of -LSB- 125I -RSB- - iodo-ovine prolactin and evaluation of prolactin_receptor assay methods .
7664695	0	prolactin_receptor	14,32	prolactin	133,142	prolactin receptor	prolactin	24684(Tax:10116)	24683(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of prolactin_receptor mRNA expression in peripheral lymphocytes in rats in response to changes in serum concentrations of prolactin .
8206330	0	prolactin_receptor	113,131	prolactin	31,40	prolactin receptor	prolactin	100757415	100750601	Gene	Gene	cDNA|compound|START_ENTITY transfected|nmod|cDNA transfected|nsubj|Endocytosis Endocytosis|nmod|END_ENTITY	Endocytosis and degradation of prolactin and its receptor in Chinese_hamster_ovary cells stably transfected with prolactin_receptor cDNA .
20643408	0	prolactin_regulatory_element-binding	23,59	ABCA1	99,104	prolactin regulatory element-binding	ABCA1	58842(Tax:10116)	313210(Tax:10116)	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Transcriptional factor prolactin_regulatory_element-binding protein-mediated gene transcription of ABCA1 via 3 ' ,5 ' - cyclic_adenosine-5 ' - monophosphate .
10194769	0	prolactin_regulatory_element_binding	49,85	PREB	43,47	prolactin regulatory element binding	PREB	58842(Tax:10116)	58842(Tax:10116)	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Expression cloning and characterization of PREB -LRB- prolactin_regulatory_element_binding -RRB- , a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity .
17475403	0	prolactin_releasing_peptide	20,47	PrRP	49,53	prolactin releasing peptide	PrRP	63850(Tax:10116)	63850(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of brain prolactin_releasing_peptide -LRB- PrRP -RRB- changes in the estrous cycle of female rats .
7295293	0	prolidase	22,31	PEP-4	33,38	prolidase	PEP-4	18624(Tax:10090)	18624(Tax:10090)	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic variation for prolidase -LRB- PEP-4 -RRB- in the mouse maps near the gene for glucosephosphate_isomerase -LRB- GPI-1 -RRB- on chromosome 7 .
12937166	0	proliferating_Cell_nuclear_antigen	10,44	p300	83,87	proliferating Cell nuclear antigen	p300	5111	2033	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	The human proliferating_Cell_nuclear_antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression .
11376153	0	proliferating_cell_nuclear_antigen	138,172	APE2	107,111	proliferating cell nuclear antigen	APE2	5111	27301	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria , while nuclear APE2 is partly associated with proliferating_cell_nuclear_antigen .
10480866	0	proliferating_cell_nuclear_antigen	22,56	DNA_polymerase_delta	102,122	proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|subunit subunit|nmod|END_ENTITY	Direct interaction of proliferating_cell_nuclear_antigen with the p125 catalytic subunit of mammalian DNA_polymerase_delta .
11595739	0	proliferating_cell_nuclear_antigen	13,47	DNA_polymerase_delta	173,193	proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	Mediation|nmod|START_ENTITY Mediation|dep|present present|nmod|subunit subunit|nmod|END_ENTITY	Mediation of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- - dependent DNA replication through a conserved p21 -LRB- Cip1 -RRB- - like PCNA-binding motif present in the third subunit of human DNA_polymerase_delta .
11986310	0	proliferating_cell_nuclear_antigen	22,56	DNA_polymerase_delta	83,103	proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|subunit subunit|nmod|END_ENTITY	Direct interaction of proliferating_cell_nuclear_antigen with the small subunit of DNA_polymerase_delta .
2563372	0	proliferating_cell_nuclear_antigen	96,130	DNA_polymerase_delta	36,56	proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	insensitive|xcomp|START_ENTITY form|acl:relcl|insensitive form|nmod|END_ENTITY	Characterization of a large form of DNA_polymerase_delta from HeLa cells that is insensitive to proliferating_cell_nuclear_antigen .
2891114	0	proliferating_cell_nuclear_antigen	20,54	DNA_polymerase_delta	109,129	proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	Autoantibody|nmod|START_ENTITY neutralizes|nsubj|Autoantibody neutralizes|dobj|activity activity|nmod|protein protein|nmod|END_ENTITY	Autoantibody to the proliferating_cell_nuclear_antigen neutralizes the activity of the auxiliary protein for DNA_polymerase_delta .
7915843	0	proliferating_cell_nuclear_antigen	46,80	DNA_polymerase_delta	127,147	proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	replication|compound|START_ENTITY replication|acl|catalyzed catalyzed|nmod|holoenzyme holoenzyme|compound|END_ENTITY	Cdk-interacting_protein_1 directly binds with proliferating_cell_nuclear_antigen and inhibits DNA replication catalyzed by the DNA_polymerase_delta holoenzyme .
8679582	0	proliferating_cell_nuclear_antigen	36,70	DNA_polymerase_delta	14,34	proliferating cell nuclear antigen	DNA polymerase delta	5111	5424	Gene	Gene	complex|dep|START_ENTITY complex|compound|END_ENTITY	The mammalian DNA_polymerase_delta -- proliferating_cell_nuclear_antigen -- template-primer complex : molecular characterization by direct binding .
9092615	0	proliferating_cell_nuclear_antigen	90,124	DNA_polymerase_delta	60,80	proliferating cell nuclear antigen	DNA polymerase delta	5111	7508	Gene	Gene	required|nmod|START_ENTITY required|nmod|interaction interaction|nmod|END_ENTITY	The small subunit is required for functional interaction of DNA_polymerase_delta with the proliferating_cell_nuclear_antigen .
10435153	0	proliferating_cell_nuclear_antigen	41,75	EGFR	34,38	proliferating cell nuclear antigen	EGFR	5111	1956	Gene	Gene	Epidermal_growth_factor_receptor|appos|START_ENTITY Epidermal_growth_factor_receptor|appos|END_ENTITY	Epidermal_growth_factor_receptor -LRB- EGFR -RRB- , proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- and Ki-67 antigen in laryngeal epithelial lesions .
20147293	0	proliferating_cell_nuclear_antigen	48,82	ELG1	6,10	proliferating cell nuclear antigen	ELG1	5111	79915	Gene	Gene	level|nmod|START_ENTITY regulates|dobj|level regulates|nsubj|END_ENTITY	Human ELG1 regulates the level of ubiquitinated proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- through Its interactions with PCNA and USP1 .
22692198	0	proliferating_cell_nuclear_antigen	42,76	Epidermal_growth_factor_receptor	0,32	proliferating cell nuclear antigen	Epidermal growth factor receptor	5111	1956	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Epidermal_growth_factor_receptor protects proliferating_cell_nuclear_antigen from cullin_4A protein-mediated proteolysis .
7673186	0	proliferating_cell_nuclear_antigen	109,143	FEN-1	100,105	proliferating cell nuclear antigen	FEN-1	5111	2237	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Lagging strand DNA synthesis at the eukaryotic replication fork involves binding and stimulation of FEN-1 by proliferating_cell_nuclear_antigen .
19125419	0	proliferating_cell_nuclear_antigen	22,56	KCTD10	0,6	proliferating cell nuclear antigen	KCTD10	5111	83892	Gene	Gene	interacts|nmod|START_ENTITY interacts|nummod|END_ENTITY	KCTD10 interacts with proliferating_cell_nuclear_antigen and its down-regulation could inhibit cell proliferation .
14642618	0	proliferating_cell_nuclear_antigen	47,81	P21	143,146	proliferating cell nuclear antigen	P21	5111	644914	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	In human hepatocellular_carcinoma in cirrhosis proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- is involved in cell proliferation and cooperates with P21 in DNA repair .
10468892	0	proliferating_cell_nuclear_antigen	34,68	PCNA	70,74	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Image cytometric DNA analysis and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in transitional cell carcinoma_of_the_bladder .
10821433	0	proliferating_cell_nuclear_antigen	40,74	PCNA	87,91	proliferating cell nuclear antigen	PCNA	25737(Tax:10116)	25737(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Butyrate inhibits proliferation-induced proliferating_cell_nuclear_antigen expression -LRB- PCNA -RRB- in rat vascular smooth muscle cells .
10899674	0	proliferating_cell_nuclear_antigen	14,48	PCNA	50,54	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in oral_submucous_fibrosis , oral epithelial_hyperkeratosis and oral_epithelial_dysplasia in Taiwan .
11130245	0	proliferating_cell_nuclear_antigen	18,52	PCNA	54,58	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in leukemia cell lines HL-60 and K-562 at the light and electron microscope level .
11578332	0	proliferating_cell_nuclear_antigen	35,69	PCNA	29,33	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunohistochemical study of PCNA -LRB- proliferating_cell_nuclear_antigen -RRB- in normal and abnormal endometrium .
1347557	0	proliferating_cell_nuclear_antigen	30,64	PCNA	66,70	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	-LSB- Immunohistochemical study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in gynecological tumors and their related lesions -RSB- .
1348631	0	proliferating_cell_nuclear_antigen	46,80	PCNA	82,86	proliferating cell nuclear antigen	PCNA	25737(Tax:10116)	25737(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of the 5 ' flanking region of the rat proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene .
1360848	0	proliferating_cell_nuclear_antigen	51,85	PCNA	87,91	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Influence of preoperative dexamethasone therapy on proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in comparison to other parameters in meningiomas .
1374182	0	proliferating_cell_nuclear_antigen	16,50	PCNA	52,56	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	Relationship of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in prostatic_carcinomas to various clinical parameters .
15857596	0	proliferating_cell_nuclear_antigen	20,54	PCNA	56,60	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in infiltrating ductal_carcinoma breast .
16269167	0	proliferating_cell_nuclear_antigen	29,63	PCNA	65,69	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in duckling liver fed with aflatoxin_B1 and esterified glucomannan .
16673899	0	proliferating_cell_nuclear_antigen	12,46	PCNA	48,52	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- associated with DNA .
1672277	0	proliferating_cell_nuclear_antigen	77,111	PCNA	113,117	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of an enhancer-like structure in the promoter region of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene .
1694073	0	proliferating_cell_nuclear_antigen	20,54	PCNA	56,60	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The promoter of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene is active in serum-derived cells .
1698875	0	proliferating_cell_nuclear_antigen	54,88	PCNA	90,94	proliferating cell nuclear antigen	PCNA	100339381(Tax:9986)	100339381(Tax:9986)	Gene	Gene	assay|nmod|START_ENTITY assay|appos|END_ENTITY	A sandwich type enzyme-linked immunosorbent assay for proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- / cyclin using monoclonal antibodies .
17098349	0	proliferating_cell_nuclear_antigen	17,51	PCNA	53,57	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- is closely associated with high-risk human_papillomavirus _ -LRB- HPV -RRB- and progression of cervical_intraepithelial_neoplasia -LRB- CIN -RRB- , but does not predict disease outcome in cervical_cancer .
17219721	0	proliferating_cell_nuclear_antigen	36,70	PCNA	72,76	proliferating cell nuclear antigen	PCNA	692192(Tax:9823)	692192(Tax:9823)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the pig ovary .
1970785	0	proliferating_cell_nuclear_antigen	26,60	PCNA	62,66	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The promoter of the human proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- gene is bidirectional .
21541548	0	proliferating_cell_nuclear_antigen	20,54	PCNA	56,60	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic value of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in unresectable hepatocellular_carcinoma .
26537947	0	proliferating_cell_nuclear_antigen	20,54	PCNA	56,60	proliferating cell nuclear antigen	PCNA	852385(Tax:4932)	852385(Tax:4932)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- from pathogenic yeast Candida_albicans and its functional analyses in S. _ Cerevisiae .
2869966	0	proliferating_cell_nuclear_antigen	47,81	PCNA	83,87	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Immunochemical and biochemical analysis of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in HeLa cells .
7474637	0	proliferating_cell_nuclear_antigen	15,49	PCNA	51,55	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in renal_cell_carcinoma -RSB- .
7596084	0	proliferating_cell_nuclear_antigen	29,63	PCNA	65,69	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	-LSB- Histochemical expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- for pre and post chemotherapeutic bladder_cancer -RSB- .
7603742	0	proliferating_cell_nuclear_antigen	76,110	PCNA	112,116	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Comparison of silver-staining nucleolar organizer region -LRB- AgNOR -RRB- counts and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in reactive mesothelial_hyperplasia and malignant_mesothelioma .
7789227	0	proliferating_cell_nuclear_antigen	15,49	PCNA	51,55	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in squamous_cell_carcinoma_of_the_oral_cavity -RSB- .
7835840	0	proliferating_cell_nuclear_antigen	27,61	PCNA	63,67	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in gliomas .
7907610	0	proliferating_cell_nuclear_antigen	19,53	PCNA	55,59	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p53 , c-myc p62 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in non-Hodgkin 's _ lymphomas .
7910645	0	proliferating_cell_nuclear_antigen	126,160	PCNA	162,166	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Expression of squamous_cell_carcinoma-associated antigen in bladder_cancer cells -- a comparative study with the expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- -RSB- .
7911055	0	proliferating_cell_nuclear_antigen	29,63	PCNA	65,69	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Clinicopathological study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- of hepatocytes in primary_biliary_cirrhosis .
7911730	0	proliferating_cell_nuclear_antigen	34,68	PCNA	70,74	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in intracranial_glioma and meningioma .
7919464	0	proliferating_cell_nuclear_antigen	11,45	PCNA	47,51	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The use of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression and intraepithelial lymphocyte count in the differential diagnosis of inflammatory_bowel_disease .
7919730	0	proliferating_cell_nuclear_antigen	20,54	PCNA	56,60	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in cancer of the ampulla of vater in terms of prognosis .
7987078	1	proliferating_cell_nuclear_antigen	171,205	PCNA	207,211	proliferating cell nuclear antigen	PCNA	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	A comparative study using immunohistochemical detection of bromodeoxyuridine -LRB- BrdU -RRB- incorporation and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression .
8096489	0	proliferating_cell_nuclear_antigen	29,63	PCNA	65,69	proliferating cell nuclear antigen	PCNA	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in endometrial_carcinoma with argyrophil cells .
8099466	0	proliferating_cell_nuclear_antigen	27,61	PCNA	63,67	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Prognostic significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in non-small_cell_lung_cancer .
8102179	0	proliferating_cell_nuclear_antigen	14,48	PCNA	50,54	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in dysplasia of the bronchial epithelium .
8587571	0	proliferating_cell_nuclear_antigen	25,59	PCNA	61,65	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Correlationship between proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression and clinicopathological factors in colorectal_cancer -RSB- .
8606541	0	proliferating_cell_nuclear_antigen	16,50	PCNA	52,56	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in gastric_cancer in relation to lymph node metastasis .
8634790	0	proliferating_cell_nuclear_antigen	13,47	PCNA	49,53	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Analysis of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in 24 cases of primary non-small_cell_pulmonary_carcinomas and correlation with survival -RSB- .
8745457	0	proliferating_cell_nuclear_antigen	15,49	PCNA	51,55	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in premalignant_lesions of laryngeal epithelium -RSB- .
8849474	0	proliferating_cell_nuclear_antigen	13,47	PCNA	49,53	proliferating cell nuclear antigen	PCNA	25737(Tax:10116)	25737(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Analysis of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in brain_tumors -RSB- .
8940694	0	proliferating_cell_nuclear_antigen	24,58	PCNA	60,64	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|nmod|START_ENTITY Study|nmod|expression Study|appos|END_ENTITY	-LSB- Study on expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in ovarian_cancer -RSB- .
9001344	0	proliferating_cell_nuclear_antigen	27,61	PCNA	63,67	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Prognostic significance of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in squamous_cell_carcinoma of the esophagus .
9042536	0	proliferating_cell_nuclear_antigen	27,61	PCNA	63,67	proliferating cell nuclear antigen	PCNA	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Abnormal expression of the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the spinal cord of the hypomyelinated Jimpy mutant mice .
9076780	0	proliferating_cell_nuclear_antigen	12,46	PCNA	48,52	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in differentiating idiopathic_orbital_inflammatory disease and lymphoid proliferations .
9350310	0	proliferating_cell_nuclear_antigen	14,48	PCNA	50,54	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in supraglottic_carcinoma .
9388366	0	proliferating_cell_nuclear_antigen	121,155	PCNA	157,161	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- The relationship between the estimated tumor growth speed and indices of bromodeoxyuridine -LRB- BrdU -RRB- incorporation and the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in superficial bladder_cancer -RSB- .
9487740	0	proliferating_cell_nuclear_antigen	12,46	PCNA	48,52	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Increase of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in HPV-18 positive oral_squamous_cell_carcinomas .
9578731	0	proliferating_cell_nuclear_antigen	98,132	PCNA	134,138	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Immunohistochemical study of the proliferation of breast_cancer cells based on the expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- -RSB- .
9589044	0	proliferating_cell_nuclear_antigen	170,204	PCNA	206,210	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Immunohistochemical study on the progression of colorectal_cancer -- with respect to apoptotic index , expression of apoptosis-related gene products , and labeling index of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- -RSB- .
9612805	0	proliferating_cell_nuclear_antigen	12,46	PCNA	48,52	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in predicting biologic behavior of lymphoid infiltrates of the orbit and ocular adnexae .
9617618	0	proliferating_cell_nuclear_antigen	66,100	PCNA	102,106	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- The relationship between the production of interleukin-6 and the proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression in renal_cell_carcinoma -RSB- .
9713473	0	proliferating_cell_nuclear_antigen	10,44	PCNA	46,50	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Bcl-2 and proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- expression correlates with subsequent local recurrence in nasopharyngeal_carcinomas .
9799997	0	proliferating_cell_nuclear_antigen	24,58	PCNA	60,64	proliferating cell nuclear antigen	PCNA	5111	5111	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The prognostic value of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- in the advanced cancer_of_larynx .
1362284	0	proliferating_cell_nuclear_antigen	16,50	PCNA/Cyclin	52,63	proliferating cell nuclear antigen	PCNA/Cyclin	5111	5111	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of proliferating_cell_nuclear_antigen -LRB- PCNA/Cyclin -RRB- in workshop cases of Hodgkin 's _ disease and non-Hodgkin 's _ lymphoma .
2566509	0	proliferating_cell_nuclear_antigen	45,79	PCNA/cyclin	81,92	proliferating cell nuclear antigen	PCNA/cyclin	394328(Tax:8355)	394328(Tax:8355)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Quantitation and subcellular localization of proliferating_cell_nuclear_antigen -LRB- PCNA/cyclin -RRB- in oocytes and eggs of Xenopus_laevis .
8105840	0	proliferating_cell_nuclear_antigen	38,72	PCNA/cyclin	74,85	proliferating cell nuclear antigen	PCNA/cyclin	5111	5111	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The immunohistochemical expression of proliferating_cell_nuclear_antigen -LRB- PCNA/cyclin -RRB- in malignant and benign_epithelial_ovarian_neoplasms and correlation with prognosis .
11554927	0	proliferating_cell_nuclear_antigen	88,122	Terminal_deoxynucleotidyltransferase	0,36	proliferating cell nuclear antigen	Terminal deoxynucleotidyltransferase	25737(Tax:10116)	294051(Tax:10116)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Terminal_deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating_cell_nuclear_antigen .
15293457	0	proliferating_cell_nuclear_antigen	15,49	bcl-2	50,55	proliferating cell nuclear antigen	bcl-2	5111	596	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	-LSB- Expression of proliferating_cell_nuclear_antigen / bcl-2 in gray gingival tissue -RSB- .
1968224	0	proliferating_cell_nuclear_antigen	11,45	cyclin	47,53	proliferating cell nuclear antigen	cyclin	37290(Tax:7227)	34924(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Drosophila proliferating_cell_nuclear_antigen -LRB- cyclin -RRB- gene : structure , expression during development , and specific binding of homeodomain proteins to its 5 ' - flanking region .
2564636	0	proliferating_cell_nuclear_antigen	15,49	cyclin	51,57	proliferating cell nuclear antigen	cyclin	394328(Tax:8355)	394328(Tax:8355)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of proliferating_cell_nuclear_antigen -LRB- cyclin -RRB- in DNA replication in living cells .
2571644	0	proliferating_cell_nuclear_antigen	14,48	cyclin	49,55	proliferating cell nuclear antigen	cyclin	5111	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of proliferating_cell_nuclear_antigen / cyclin in human keratinocytes .
2874992	0	proliferating_cell_nuclear_antigen	14,48	cyclin	56,62	proliferating cell nuclear antigen	cyclin	18538(Tax:10090)	18538(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of proliferating_cell_nuclear_antigen -LRB- PCNA -RRB- / cyclin during the cell cycle .
7553644	0	proliferating_cell_nuclear_antigen	139,173	cyclin_D1	89,98	proliferating cell nuclear antigen	cyclin D1	5111	595	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Immortalization of human fibroblasts by SV40 large T antigen results in the reduction of cyclin_D1 expression and subunit association with proliferating_cell_nuclear_antigen and Waf1 .
8655964	0	proliferating_cell_nuclear_antigen	22,56	epidermal_growth_factor_receptor	115,147	proliferating cell nuclear antigen	epidermal growth factor receptor	25737(Tax:10116)	24329(Tax:10116)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|nmod|END_ENTITY	The overexpression of proliferating_cell_nuclear_antigen in biliary_cirrhosis in the rat and its relationship with epidermal_growth_factor_receptor .
17636311	0	proliferating_cell_nuclear_antigen	44,78	estrogen_receptor_alpha	15,38	proliferating cell nuclear antigen	estrogen receptor alpha	5111	2099	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of estrogen_receptor_alpha with proliferating_cell_nuclear_antigen .
10744741	0	proliferating_cell_nuclear_antigen	18,52	flap_endonuclease_1	64,83	proliferating cell nuclear antigen	flap endonuclease 1	5111	2237	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|END_ENTITY	Mechanism whereby proliferating_cell_nuclear_antigen stimulates flap_endonuclease_1 .
16711022	0	proliferating_cell_nuclear_antigen	104,138	follicle-stimulating_hormone_receptor	45,82	proliferating cell nuclear antigen	follicle-stimulating hormone receptor	5111	2492	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effects of antisense oligodeoxynucleotide to follicle-stimulating_hormone_receptor on the expression of proliferating_cell_nuclear_antigen and vascular_endothelial_growth_factor in primary culture cells derived from human ovarian_mucinous_cystadenocarcinoma .
12509454	0	proliferating_cell_nuclear_antigen	19,53	p21	0,3	proliferating cell nuclear antigen	p21	18538(Tax:10090)	12575(Tax:10090)	Gene	Gene	level|compound|START_ENTITY Controls|dobj|level Controls|nsubj|END_ENTITY	p21 -LRB- CIP1 -RRB- Controls proliferating_cell_nuclear_antigen level in adult cardiomyocytes .
17166098	0	proliferating_cell_nuclear_antigen	90,124	transforming_growth_factor-alpha	15,47	proliferating cell nuclear antigen	transforming growth factor-alpha	5111	7124	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of transforming_growth_factor-alpha and epidermal_growth_factor_receptor with proliferating_cell_nuclear_antigen in human burn wounds .
16216562	0	proliferating_cell_nuclear_antigen	81,115	uracil-DNA_glycosylase	53,75	proliferating cell nuclear antigen	uracil-DNA glycosylase	5111	7374	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of human nuclear uracil-DNA_glycosylase with proliferating_cell_nuclear_antigen .
7546052	0	proliferation-associated_nuclear_antigen	36,76	p105	78,82	proliferation-associated nuclear antigen	p105	4790	4790	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Flow cytometric characterization of proliferation-associated_nuclear_antigen -LRB- p105 -RRB- during the cell cycle in normal lymphocytes and promyelocytic_leukemia cells -LRB- HL-60 -RRB- .
1367039	0	proliferation_suppressing_factor	36,68	PC-8	100,104	proliferation suppressing factor	PC-8	3490	9159	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification and some properties of proliferation_suppressing_factor from human lung_adenocarcinoma PC-8 .
8545595	0	proliferative_cell_nuclear_antigen	18,52	PCNA	54,58	proliferative cell nuclear antigen	PCNA	5111	5111	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the proliferative_cell_nuclear_antigen -LRB- PCNA -RRB- in adenocarcinoma_of_the_gallbladder , and its relationship to prognosis .
11316781	0	proliferin	34,44	mitogen-regulated_protein	8,33	proliferin	mitogen-regulated protein	18811(Tax:10090)	17250(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Mrp3 , a mitogen-regulated_protein / proliferin gene expressed in wound healing and in hair follicles .
1815996	0	proliferin	64,74	mitogen-regulated_protein	32,57	proliferin	mitogen-regulated protein	18811(Tax:10090)	17250(Tax:10090)	Gene	Gene	MRP|dep|START_ENTITY END_ENTITY|appos|MRP	Regulation of the expression of mitogen-regulated_protein -LRB- MRP ; proliferin -RRB- and cathepsin_L in cultured cells and in the murine placenta .
1550127	0	proline-rich_protein	78,98	PRP	100,103	proline-rich protein	PRP	722	722	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	PRB2/1 fusion gene : a product of unequal and homologous crossing-over between proline-rich_protein -LRB- PRP -RRB- genes PRB1 and PRB2 .
2613230	0	proline-rich_protein	5,25	Prp	0,3	proline-rich protein	Prp	19131(Tax:10090)	19131(Tax:10090)	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Prp -LRB- proline-rich_protein -RRB- genes linked to markers Es-12 -LRB- esterase-12 -RRB- , Ea-10 -LRB- erythrocyte alloantigen -RRB- , and loci on distal mouse chromosome 6 .
21372295	0	proline-rich_tyrosine_kinase	63,91	p300	211,215	proline-rich tyrosine kinase	p300	19229(Tax:10090)	328572(Tax:10090)	Gene	Gene	system|amod|START_ENTITY system|amod|END_ENTITY	Early inflammatory reactions in atherosclerosis are induced by proline-rich_tyrosine_kinase / reactive oxygen species-mediated release of tumor_necrosis_factor-alpha and subsequent activation of the p21Cip1/Ets -1 / p300 system .
12077257	0	proline-rich_tyrosine_kinase-2	23,53	Pyk2	55,59	proline-rich tyrosine kinase-2	Pyk2	2185	2185	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	TCR engagement induces proline-rich_tyrosine_kinase-2 -LRB- Pyk2 -RRB- translocation to the T cell-APC interface independently of Pyk2 activity and in an immunoreceptor tyrosine-based activation motif-mediated fashion .
19919693	0	proline-rich_tyrosine_kinase2	25,54	PYK2	56,60	proline-rich tyrosine kinase2	PYK2	2185	2185	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Functional activation of proline-rich_tyrosine_kinase2 -LRB- PYK2 -RRB- in peripheral blood mononuclear cells from patients with systemic_lupus_erythematosus .
17551499	0	proline-rich_tyrosine_kinase2	20,49	Pyk2	51,55	proline-rich tyrosine kinase2	Pyk2	2185	2185	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The significance of proline-rich_tyrosine_kinase2 -LRB- Pyk2 -RRB- on hepatocellular_carcinoma progression and recurrence .
19433356	0	proline-rich_tyrosine_kinase_2	100,130	PYK2	132,136	proline-rich tyrosine kinase 2	PYK2	2185	2185	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich_tyrosine_kinase_2 -LRB- PYK2 -RRB- inhibitors : retrospective analysis by CYP3A4 molecular docking , quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry .
19930834	0	proline-rich_tyrosine_kinase_2	29,59	PYK2	61,65	proline-rich tyrosine kinase 2	PYK2	2185	2185	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and activation of proline-rich_tyrosine_kinase_2 -LRB- PYK2 -RRB- in peripheral blood mononuclear cells from patients with systemic_lupus_erythematosus .
11311138	0	proline-rich_tyrosine_kinase_2	78,108	THP-1	112,117	proline-rich tyrosine kinase 2	THP-1	2185	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Monocyte_chemoattractant_protein_1 causes differential signalling mediated by proline-rich_tyrosine_kinase_2 in THP-1 cells .
15539082	0	proline-rich_tyrosine_kinase_2	50,80	beta1-integrins	116,131	proline-rich tyrosine kinase 2	beta1-integrins	2185	3688	Gene	Gene	phosphorylation|amod|START_ENTITY mediates|dobj|phosphorylation mediates|nmod|END_ENTITY	Phosphatidylinositol-3-kinase activation mediates proline-rich_tyrosine_kinase_2 phosphorylation and recruitment to beta1-integrins in human CD34 + cells .
21061267	0	proline_rich_15	23,38	Prr15	40,45	proline rich 15	Prr15	78004(Tax:10090)	78004(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression analysis of proline_rich_15 -LRB- Prr15 -RRB- in mouse and human gastrointestinal_tumors .
22096562	0	proline_rich_tyrosine_kinase_2	12,42	Pyk2	44,48	proline rich tyrosine kinase 2	Pyk2	19229(Tax:10090)	19229(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of proline_rich_tyrosine_kinase_2 -LRB- Pyk2 -RRB- on cisplatin resistance in hepatocellular_carcinoma .
10496079	0	proline_synthetase_co-transcribed	55,88	PROSC	48,53	proline synthetase co-transcribed	PROSC	114863(Tax:10090)	114863(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Cloning and characterization of human and mouse PROSC -LRB- proline_synthetase_co-transcribed -RRB- genes .
26966067	0	prolyl_4-hydroxylase_subunit_alpha-1	65,101	P4HA1	103,108	prolyl 4-hydroxylase subunit alpha-1	P4HA1	5033	5033	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl_4-hydroxylase_subunit_alpha-1 -LRB- P4HA1 -RRB- mRNA .
24024131	0	prolyl_carboxypeptidase	31,54	Ghrelin	0,7	prolyl carboxypeptidase	Ghrelin	72461(Tax:10090)	58991(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ghrelin regulates hypothalamic prolyl_carboxypeptidase expression in mice .
10499517	0	prolyl_endopeptidase	132,152	GnRH	168,172	prolyl endopeptidase	GnRH	83471(Tax:10116)	25194(Tax:10116)	Gene	Gene	degradation|amod|START_ENTITY degradation|nmod|END_ENTITY	Early prepubertal ontogeny of pulsatile gonadotropin-releasing_hormone -LRB- GnRH -RRB- secretion : I. Inhibitory autofeedback control through prolyl_endopeptidase degradation of GnRH .
10708824	0	prolyl_endopeptidase	43,63	PEP	65,68	prolyl endopeptidase	PEP	5550	5550	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of pregnancy and delivery on serum prolyl_endopeptidase -LRB- PEP -RRB- activity : alterations in serum PEP are related to increased anxiety in the early puerperium and to postpartum depression .
22360728	0	prolyl_hydroxylase_2	62,82	HIF-1	53,58	prolyl hydroxylase 2	HIF-1	54583	3091	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|regulation regulation|nmod|END_ENTITY	Role of reactive oxygen species in the regulation of HIF-1 by prolyl_hydroxylase_2 under mild hypoxia .
20404338	0	prolyl_hydroxylase_domain-containing_protein_2	49,95	PHD2	97,101	prolyl hydroxylase domain-containing protein 2	PHD2	54583	54583	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of hypoxia-inducible factor-targeting prolyl_hydroxylase_domain-containing_protein_2 -LRB- PHD2 -RRB- enhances matrix synthesis by human chondrocytes .
24753072	0	prolyl_hydroxylase_domain-containing_protein_2	30,76	Phd2	78,82	prolyl hydroxylase domain-containing protein 2	Phd2	112405(Tax:10090)	112405(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Conditional disruption of the prolyl_hydroxylase_domain-containing_protein_2 -LRB- Phd2 -RRB- gene defines its key role in skeletal development .
17933562	0	prolyl_hydroxylase_domain_protein_2	140,175	PHD2	177,181	prolyl hydroxylase domain protein 2	PHD2	54583	54583	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Disturbance in the HIF-1alpha pathway associated with erythrocytosis : further evidences brought by frameshift and nonsense mutations in the prolyl_hydroxylase_domain_protein_2 -LRB- PHD2 -RRB- gene .
21828119	0	prolyl_hydroxylase_domain_protein_2	107,142	PHD2	144,148	prolyl hydroxylase domain protein 2	PHD2	54583	54583	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolated erythrocytosis : study of 67 patients and identification of three novel germ-line mutations in the prolyl_hydroxylase_domain_protein_2 -LRB- PHD2 -RRB- gene .
19171072	0	prolylcarboxypeptidase	16,38	PRCP	40,44	prolylcarboxypeptidase	PRCP	5547	5547	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of prolylcarboxypeptidase -LRB- PRCP -RRB- in lipopolysaccharide -LRB- LPS -RRB- treated endothelium promotes inflammation .
23318676	0	prominin-1	45,55	CD133	56,61	prominin-1	CD133	8842	8842	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|END_ENTITY	Wnt interaction and extracellular release of prominin-1 / CD133 in human malignant_melanoma cells .
21215282	0	promyelocytic_leukemia	14,36	PML	38,41	promyelocytic leukemia	PML	5371	5371	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Regulation of promyelocytic_leukemia -LRB- PML -RRB- protein levels and cell morphology by bovine_herpesvirus_1 infected cell protein 0 -LRB- bICP0 -RRB- and mutant bICP0 proteins that do not localize to the nucleus .
21057547	0	promyelocytic_leukemia_protein	42,72	AXIN	0,4	promyelocytic leukemia protein	AXIN	5371	8312	Gene	Gene	co-activator|nmod|START_ENTITY co-activator|nsubj|END_ENTITY	AXIN is an essential co-activator for the promyelocytic_leukemia_protein in p53 activation .
22906876	0	promyelocytic_leukemia_protein	15,45	IL-6	65,69	promyelocytic leukemia protein	IL-6	5371	3569	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Association of promyelocytic_leukemia_protein with expression of IL-6 and resistance to treatment in multiple_myeloma .
22711534	0	promyelocytic_leukemia_protein	34,64	Interleukin_6	0,13	promyelocytic leukemia protein	Interleukin 6	5371	3569	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|signaling signaling|compound|END_ENTITY	Interleukin_6 signaling regulates promyelocytic_leukemia_protein gene expression in human normal and cancer cells .
15383670	0	promyelocytic_leukemia_protein	57,87	PML	89,92	promyelocytic leukemia protein	PML	5371	5371	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Establishment of papillomavirus_infection is enhanced by promyelocytic_leukemia_protein -LRB- PML -RRB- expression .
9819401	0	promyelocytic_leukemia_protein	4,34	Sp1	50,53	promyelocytic leukemia protein	Sp1	5371	6667	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The promyelocytic_leukemia_protein interacts with Sp1 and inhibits its transactivation of the epidermal_growth_factor_receptor promoter .
11485412	0	promyelocytic_leukemia_protein	60,90	p53	117,120	promyelocytic leukemia protein	p53	5371	7157	Gene	Gene	colocalizes|nmod|START_ENTITY bodies|nsubj|colocalizes bodies|dobj|END_ENTITY	Human-herpesvirus-8-encoded K8 protein colocalizes with the promyelocytic_leukemia_protein -LRB- PML -RRB- bodies and recruits p53 to the PML bodies .
12810724	0	promyelocytic_leukemia_protein	4,34	p53	44,47	promyelocytic leukemia protein	p53	5371	7157	Gene	Gene	protects|nsubj|START_ENTITY protects|dobj|END_ENTITY	The promyelocytic_leukemia_protein protects p53 from Mdm2-mediated inhibition and degradation .
21057547	0	promyelocytic_leukemia_protein	42,72	p53	76,79	promyelocytic leukemia protein	p53	5371	7157	Gene	Gene	START_ENTITY|nmod|activation activation|compound|END_ENTITY	AXIN is an essential co-activator for the promyelocytic_leukemia_protein in p53 activation .
14527952	0	promyelocytic_leukemia_zinc_finger	16,50	PLZF	60,64	promyelocytic leukemia zinc finger	PLZF	7704	7704	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Modification of promyelocytic_leukemia_zinc_finger protein -LRB- PLZF -RRB- by SUMO-1 conjugation regulates its transcriptional repressor activity .
24821727	0	promyelocytic_leukemia_zinc_finger	8,42	PLZF	44,48	promyelocytic leukemia zinc finger	PLZF	235320(Tax:10090)	235320(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of promyelocytic_leukemia_zinc_finger -LRB- PLZF -RRB- in cell proliferation and cyclin-dependent kinase inhibitor 1A -LRB- p21WAF/CDKN1A -RRB- gene repression .
23355739	0	promyelocytic_zinc_finger_transcription_factor	37,83	Ly108	11,16	promyelocytic zinc finger transcription factor	Ly108	235320(Tax:10090)	30925(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for Ly108 in the induction of promyelocytic_zinc_finger_transcription_factor in developing thymocytes .
17470519	0	proopiomelanocortin	63,82	Corticotropin-releasing_hormone	0,31	proopiomelanocortin	Corticotropin-releasing hormone	24664(Tax:10116)	81648(Tax:10116)	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Corticotropin-releasing_hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter .
10487685	0	proopiomelanocortin	74,93	POMC	100,104	proopiomelanocortin	POMC	5443	5443	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Normal variation in leptin levels in associated with polymorphisms in the proopiomelanocortin gene , POMC .
11244459	0	proopiomelanocortin	27,46	POMC	48,52	proopiomelanocortin	POMC	5443	5443	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular screening of the proopiomelanocortin -LRB- POMC -RRB- gene in Italian obese children : report of three new mutations .
17764572	0	proopiomelanocortin	12,31	POMC	33,37	proopiomelanocortin	POMC	5443	5443	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of proopiomelanocortin -LRB- POMC -RRB- neurones in feeding behaviour .
18688808	0	proopiomelanocortin	12,31	POMC	33,37	proopiomelanocortin	POMC	5443	5443	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of proopiomelanocortin -LRB- POMC -RRB- in sequentially dependent self-injurious behavior .
19036902	0	proopiomelanocortin	33,52	POMC	54,58	proopiomelanocortin	POMC	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Liver_X_receptor-alpha regulates proopiomelanocortin -LRB- POMC -RRB- gene transcription in the pituitary .
22570972	0	proopiomelanocortin	120,139	POMC	141,145	proopiomelanocortin	POMC	5443	5443	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A case of early-onset obesity , hypocortisolism , and skin pigmentation problem due to a novel homozygous mutation in the proopiomelanocortin -LRB- POMC -RRB- gene in an Indian boy .
23218956	0	proopiomelanocortin	27,46	POMC	48,52	proopiomelanocortin	POMC	5443	5443	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of proopiomelanocortin -LRB- POMC -RRB- transcriptional variants in human skin cells .
2527570	0	proopiomelanocortin	16,35	POMC	37,41	proopiomelanocortin	POMC	396863(Tax:9823)	396863(Tax:9823)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of proopiomelanocortin -LRB- POMC -RRB- immunoreactive neurons in the forebrain of the pig .
2545484	0	proopiomelanocortin	42,61	POMC	63,67	proopiomelanocortin	POMC	5443	5443	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cyclic_AMP-responsive region of the human proopiomelanocortin -LRB- POMC -RRB- gene .
2550299	0	proopiomelanocortin	41,60	POMC	62,66	proopiomelanocortin	POMC	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Effect of ethane_dimethane_sulphonate on proopiomelanocortin -LRB- POMC -RRB- mRNA and POMC-derived peptides in the rat testis .
26753719	0	proopiomelanocortin	83,102	POMC	109,113	proopiomelanocortin	POMC	5443	5443	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations among child_abuse , mental health , and epigenetic modifications in the proopiomelanocortin gene -LRB- POMC -RRB- : A study with children in Tanzania .
8003951	0	proopiomelanocortin	4,23	POMC	25,29	proopiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The proopiomelanocortin -LRB- POMC -RRB- gene expression of AtT20 mouse pituitary cells is dependent on cell culture conditions .
8094652	0	proopiomelanocortin	71,90	POMC	92,96	proopiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of corticotrophin-releasing_factor and arginine-vasopressin on proopiomelanocortin -LRB- POMC -RRB- mRNA levels , release and storage of adrenocorticotrophin from mouse anterior pituitary cells .
8413862	0	proopiomelanocortin	21,40	POMC	42,46	proopiomelanocortin	POMC	24664(Tax:10116)	24664(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Opioid regulation of proopiomelanocortin -LRB- POMC -RRB- gene expression in the rat brain as studied by in situ hybridization .
8536378	0	proopiomelanocortin	24,43	POMC	45,49	proopiomelanocortin	POMC	18976(Tax:10090)	18976(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Increased expression of proopiomelanocortin -LRB- POMC -RRB- mRNA in adrenal glands of mice undergoing graft-versus-host_disease -LRB- GVHD -RRB- : association with persistent elevated plasma corticosterone levels .
8781560	0	proopiomelanocortin	26,45	POMC	47,51	proopiomelanocortin	POMC	5443	5443	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and release of proopiomelanocortin -LRB- POMC -RRB- derived peptides by human melanocytes and keratinocytes in culture : regulation by ultraviolet B .
8094652	0	proopiomelanocortin	71,90	corticotrophin-releasing_factor	11,42	proopiomelanocortin	corticotrophin-releasing factor	18976(Tax:10090)	12917(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of corticotrophin-releasing_factor and arginine-vasopressin on proopiomelanocortin -LRB- POMC -RRB- mRNA levels , release and storage of adrenocorticotrophin from mouse anterior pituitary cells .
1628218	0	proopiomelanocortin	83,102	corticotropin-releasing_factor	12,42	proopiomelanocortin	corticotropin-releasing factor	24664(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of corticotropin-releasing_factor and vasopressin in hypoglycemia-induced proopiomelanocortin gene expression in the rat anterior pituitary gland .
10536983	0	proopiomelanocortin	14,33	corticotropin-releasing_hormone	35,66	proopiomelanocortin	corticotropin-releasing hormone	5443	1392	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of proopiomelanocortin , corticotropin-releasing_hormone -LRB- CRH -RRB- , and CRH receptor in melanoma cells , nevus cells , and normal human melanocytes .
16840545	0	proopiomelanocortin	65,84	corticotropin-releasing_hormone	235,266	proopiomelanocortin	corticotropin-releasing hormone	24664(Tax:10116)	404297(Tax:9031)	Gene	Gene	acid|nmod|START_ENTITY coexpressing|dobj|acid type|acl|coexpressing type|dep|decline decline|acl|vitro vitro|nmod|pressure pressure|nmod|END_ENTITY	A Pituitary cell type coexpressing messenger ribonucleic acid of proopiomelanocortin and the glycoprotein_hormone_alpha-subunit in neonatal rat and chicken : rapid decline with age and reappearance in vitro under regulatory pressure of corticotropin-releasing_hormone in the rat .
18827746	0	proopiomelanocortin	46,65	corticotropin-releasing_hormone	113,144	proopiomelanocortin	corticotropin-releasing hormone	5443	1392	Gene	Gene	derivatives|compound|START_ENTITY Release|nmod|derivatives Release|nmod|END_ENTITY	Release of melanotroph - and corticotroph-type proopiomelanocortin derivatives into blood after administration of corticotropin-releasing_hormone in patients with septic_shock without adrenocortical_insufficiency .
23891702	0	proopiomelanocortin	46,65	corticotropin-releasing_hormone	11,42	proopiomelanocortin	corticotropin-releasing hormone	5443	1392	Gene	Gene	derivatives|compound|START_ENTITY Effects|nmod|derivatives Effects|nmod|END_ENTITY	Effects of corticotropin-releasing_hormone on proopiomelanocortin derivatives and monocytic HLA-DR expression in patients with septic_shock .
2839542	0	proopiomelanocortin	64,83	corticotropin-releasing_hormone	11,42	proopiomelanocortin	corticotropin-releasing hormone	5443	1392	Gene	Gene	messenger|compound|START_ENTITY END_ENTITY|nmod|messenger	Effects of corticotropin-releasing_hormone and dexamethasone on proopiomelanocortin messenger RNA level in human corticotroph_adenoma cells in vitro .
2856398	0	proopiomelanocortin	40,59	corticotropin-releasing_hormone	82,113	proopiomelanocortin	corticotropin-releasing hormone	5443	1392	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene transcription|nsubj|regulation transcription|nmod|END_ENTITY	Tissue-specific regulation of pituitary proopiomelanocortin gene transcription by corticotropin-releasing_hormone , 3 ' ,5 ' - cyclic_adenosine_monophosphate , and glucocorticoids .
21211522	0	proopiomelanocortin	41,60	estrogen_receptor_a	4,23	proopiomelanocortin	estrogen receptor a	18976(Tax:10090)	13982(Tax:10090)	Gene	Gene	colocalizes|nmod|START_ENTITY colocalizes|nsubj|END_ENTITY	The estrogen_receptor_a colocalizes with proopiomelanocortin in hypothalamic neurons and binds to a conserved motif present in the neuron-specific enhancer nPE2 .
17332528	0	proopiomelanocortin	119,138	leptin	160,166	proopiomelanocortin	leptin	5443	3952	Gene	Gene	START_ENTITY|dep|effects effects|nmod|END_ENTITY	Glucose regulates AMP-activated protein kinase activity and gene expression in clonal , hypothalamic neurons expressing proopiomelanocortin : additive effects of leptin or insulin .
8218649	0	proopiomelanocortin	49,68	neuropeptide-Y	33,47	proopiomelanocortin	neuropeptide-Y	443212(Tax:9940)	443508(Tax:9940)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Influence of food restriction on neuropeptide-Y , proopiomelanocortin , and luteinizing hormone-releasing hormone gene expression in sheep_hypothalami .
1901963	0	proopiomelanocortin	27,46	neuropeptide_Y	72,86	proopiomelanocortin	neuropeptide Y	24664(Tax:10116)	24604(Tax:10116)	Gene	Gene	interactions|nmod|START_ENTITY interactions|dep|peptides peptides|advmod|END_ENTITY	Anatomical interactions of proopiomelanocortin -LRB- POMC -RRB- - related peptides , neuropeptide_Y -LRB- NPY -RRB- and dopamine beta-hydroxylase -LRB- D beta H -RRB- fibers and thyrotropin-releasing_hormone -LRB- TRH -RRB- neurons in the paraventricular nucleus of rat hypothalamus .
7773678	0	proopiomelanocortin	14,33	neuropeptide_Y	53,67	proopiomelanocortin	neuropeptide Y	24664(Tax:10116)	24604(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of proopiomelanocortin gene expression by neuropeptide_Y in the rat arcuate nucleus .
12697721	0	proopiomelanocortin	89,108	signal_transducer_and_activator_of_transcription_3	8,58	proopiomelanocortin	signal transducer and activator of transcription 3	24664(Tax:10116)	25125(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin .
3237219	0	properdin	37,46	complement_factor_P	16,35	properdin	complement factor P	5199	5199	Gene	Gene	Biosynthesis|appos|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of complement_factor_P -LRB- properdin -RRB- by the human pre-monocyte cell line -LRB- U-937 -RRB- .
16384867	0	prophet_of_Pit1	8,23	PROP1	25,30	prophet of Pit1	PROP1	19127(Tax:10090)	19127(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of prophet_of_Pit1 -LRB- PROP1 -RRB- in gonadotrope differentiation and puberty .
12191492	0	proprotein_convertase_2	66,89	PC2	91,94	proprotein convertase 2	PC2	5126	5126	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of a repressor element in the promoter region of proprotein_convertase_2 -LRB- PC2 -RRB- gene .
21122852	0	proprotein_convertase_subtilisin-kexin_type_9	45,90	apolipoprotein_M	23,39	proprotein convertase subtilisin-kexin type 9	apolipoprotein M	255738	55937	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|nmod|levels	Relationship of plasma apolipoprotein_M with proprotein_convertase_subtilisin-kexin_type_9 levels in non-diabetic subjects .
19768174	0	proprotein_convertase_subtilisin_kexin-9	38,78	PCSK9	80,85	proprotein convertase subtilisin kexin-9	PCSK9	255738	255738	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Statins and ezetimibe modulate plasma proprotein_convertase_subtilisin_kexin-9 -LRB- PCSK9 -RRB- levels .
26183252	0	proprotein_convertase_subtilisin_kexin_9	35,75	PCSK9	77,82	proprotein convertase subtilisin kexin 9	PCSK9	255738	255738	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Effect of statin therapy on plasma proprotein_convertase_subtilisin_kexin_9 -LRB- PCSK9 -RRB- concentrations : a systematic review and meta-analysis of clinical trials .
20579883	0	prorenin_receptor	68,85	dPRR	32,36	prorenin receptor	dPRR	10159	41104(Tax:7227)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Wnt/Frizzled signaling requires dPRR , the Drosophila homolog of the prorenin_receptor .
8641138	0	prosaposin	24,34	PSAP	41,45	prosaposin	PSAP	5660	5660	Gene	Gene	gene|compound|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of the human prosaposin gene -LRB- PSAP -RRB- to 10q22 .1 by fluorescence in situ hybridization .
12965054	0	prosaposin	111,121	SGP-1	123,128	prosaposin	SGP-1	25524(Tax:10116)	25524(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Regulation of gene expression in response to brain_injury : enhanced expression and alternative splicing of rat prosaposin -LRB- SGP-1 -RRB- mRNA in injured brain .
9266755	0	prosaposin	33,43	SGP-1	45,50	prosaposin	SGP-1	19156(Tax:10090)	109941(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structural analysis of the mouse prosaposin -LRB- SGP-1 -RRB- gene reveals the presence of an exon that is alternatively spliced in transcribed mRNAs .
8573994	0	prosaposin	49,59	sulfated_glycoprotein-1	18,41	prosaposin	sulfated glycoprotein-1	5660	25524(Tax:10116)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Molecular role of sulfated_glycoprotein-1 -LRB- SGP-1 / prosaposin -RRB- in Sertoli cells .
9313760	0	prostacyclin-stimulating_factor	29,60	PSF	62,65	prostacyclin-stimulating factor	PSF	3490	3490	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of prostacyclin-stimulating_factor -LRB- PSF -RRB- in the diabetic and atherosclerotic human coronary artery .
8248548	0	prostaglandin	60,73	interleukin-6	11,24	interleukin-6	interleukin-6	3569	3569	Gene	Gene	production|compound|START_ENTITY Effects|nmod|production Effects|nmod|END_ENTITY	Effects of interleukin-6 and tumor_necrosis_factor-alpha on prostaglandin production by cultured human fetal membranes .
20025057	0	prostaglandin-E_synthase	46,70	cyclooxygenase-2	14,30	prostaglandin-E synthase	cyclooxygenase-2	59103(Tax:10116)	29527(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	Expression of cyclooxygenase-2 and microsomal prostaglandin-E_synthase in amoeboid microglial cells in the developing brain and effects of cyclooxygenase-2 neutralization on BV-2 microglial cells .
24423291	0	prostaglandin-endoperoxidase_synthase_2	29,68	PTGS2	70,75	prostaglandin-endoperoxidase synthase 2	PTGS2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hormonal therapy deregulates prostaglandin-endoperoxidase_synthase_2 -LRB- PTGS2 -RRB- expression in endometriotic tissues .
21915288	0	prostaglandin-endoperoxidase_synthase_2	22,61	miR-143	0,7	prostaglandin-endoperoxidase synthase 2	miR-143	5743	406935	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	miR-143 regulation of prostaglandin-endoperoxidase_synthase_2 in the amnion : implications for human parturition at term .
24641411	0	prostaglandin-endoperoxide_synthase_2	54,91	PLA2G2A	134,141	prostaglandin-endoperoxide synthase 2	PLA2G2A	5743	5320	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association of single nucleotide polymorphisms in the prostaglandin-endoperoxide_synthase_2 -LRB- PTGS2 -RRB- and phospholipase A group IIA -LRB- PLA2G2A -RRB- genes with susceptibility to esophageal_squamous_cell_carcinoma .
16553209	0	prostaglandin-endoperoxide_synthase_2	29,66	PTGS2	68,73	prostaglandin-endoperoxide synthase 2	PTGS2	397590(Tax:9823)	397590(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variation of porcine prostaglandin-endoperoxide_synthase_2 -LRB- PTGS2 -RRB- gene and its association with reproductive traits in an Erhualian x Duroc F2 population .
20018844	0	prostaglandin-endoperoxide_synthase_2	28,65	Ptgs2	67,72	prostaglandin-endoperoxide synthase 2	Ptgs2	5743	5743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Growth factor regulation of prostaglandin-endoperoxide_synthase_2 -LRB- Ptgs2 -RRB- expression in colonic mesenchymal stem cells .
19342459	0	prostaglandin-endoperoxide_synthase_2	73,110	Runt-related_transcription_factor_1	0,35	prostaglandin-endoperoxide synthase 2	Runt-related transcription factor 1	29527(Tax:10116)	50662(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Runt-related_transcription_factor_1 regulates luteinized hormone-induced prostaglandin-endoperoxide_synthase_2 expression in rat periovulatory granulosa cells .
25698598	0	prostaglandin_D2	9,25	CRTH2	0,5	prostaglandin D2	CRTH2	19215(Tax:10090)	14764(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|appos|receptor	CRTH2 , a prostaglandin_D2 receptor , mediates depression-related behavior in mice .
7036145	0	prostaglandin_D2	14,30	PGD2	32,36	prostaglandin D2	PGD2	5730	5730	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of prostaglandin_D2 -LRB- PGD2 -RRB- as an anticoagulative agent for haemodialysis in comparison with prostaglandin_E1 -LRB- PGE1 -RRB- .
24029383	0	prostaglandin_D2	86,102	lipocalin-prostaglandin_D_synthase	40,74	prostaglandin D2	lipocalin-prostaglandin D synthase	19215(Tax:10090)	19215(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Nrf2 is essential for the expression of lipocalin-prostaglandin_D_synthase induced by prostaglandin_D2 .
7594606	0	prostaglandin_D2	97,113	prostaglandin_endoperoxide_synthase-2	129,166	prostaglandin D2	prostaglandin endoperoxide synthase-2	19215(Tax:10090)	19225(Tax:10090)	Gene	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin_D2 generation via prostaglandin_endoperoxide_synthase-2 .
22960220	0	prostaglandin_D2	19,35	retinoid-inducible_gene_1	54,79	prostaglandin D2	retinoid-inducible gene 1	5730	5920	Gene	Gene	pathway|amod|START_ENTITY pathway|nmod|END_ENTITY	Involvement of the prostaglandin_D2 signal pathway in retinoid-inducible_gene_1 -LRB- RIG1 -RRB- - mediated suppression of cell invasion in testis_cancer cells .
22370065	0	prostaglandin_D2_synthase	27,52	PTGDS	54,59	prostaglandin D2 synthase	PTGDS	5730	5730	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of prostaglandin_D2_synthase -LRB- PTGDS -RRB- in patients with attention_deficit-hyperactivity_disorder and bipolar_disorder .
17277314	0	prostaglandin_D_synthase	15,39	SOX9	0,4	prostaglandin D synthase	SOX9	19215(Tax:10090)	20682(Tax:10090)	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	SOX9 regulates prostaglandin_D_synthase gene transcription in vivo to ensure testis development .
17532558	0	prostaglandin_D_synthase	38,62	SOX9	63,67	prostaglandin D synthase	SOX9	5730	6662	Gene	Gene	role|nmod|START_ENTITY role|dep|pathway pathway|nummod|END_ENTITY	Expression and biological role of the prostaglandin_D_synthase / SOX9 pathway in human ovarian_cancer cells .
15087710	0	prostaglandin_D_synthase	53,77	interleukin-1beta	11,28	prostaglandin D synthase	interleukin-1beta	25526(Tax:10116)	24494(Tax:10116)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effects of interleukin-1beta and prostaglandin_E2 on prostaglandin_D_synthase production in cultivated rat leptomeningeal cells .
19201881	0	prostaglandin_E2	98,114	epidermal_growth_factor_receptor	52,84	Cyclooxygenase 2	epidermal growth factor receptor	5743	1956	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Lipopolysaccharide initiates a positive feedback of epidermal_growth_factor_receptor signaling by prostaglandin_E2 in human biliary_carcinoma cells .
14634592	0	prostaglandin_E2_receptor_type_4	37,69	EP4	71,74	prostaglandin E2 receptor type 4	EP4	84023(Tax:10116)	84023(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of the rat prostaglandin_E2_receptor_type_4 -LRB- EP4 -RRB- in pregnant cervical tissue .
12087061	0	prostaglandin_H_synthase-2	10,36	PHS-2	38,43	prostaglandin H synthase-2	PHS-2	19225(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Embryonic prostaglandin_H_synthase-2 -LRB- PHS-2 -RRB- expression and benzo -LSB- a -RSB- pyrene teratogenicity in PHS-2 knockout mice .
317602	0	prostaglandin_dehydrogenase	43,70	PGDH	72,76	prostaglandin dehydrogenase	PGDH	15446(Tax:10090)	15446(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Effect of ionizing radiation on 15-hydroxy prostaglandin_dehydrogenase -LRB- PGDH -RRB- activity in tissues .
6206113	0	prostaglandin_dehydrogenase	50,77	PGDH	79,83	prostaglandin dehydrogenase	PGDH	79242(Tax:10116)	79242(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Effect of exposure to diesel exhaust on pulmonary prostaglandin_dehydrogenase -LRB- PGDH -RRB- activity .
9068062	0	prostaglandin_endoperoxide_H_synthase-2	19,58	PHS-2	60,65	prostaglandin endoperoxide H synthase-2	PHS-2	5743	5743	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Induction of human prostaglandin_endoperoxide_H_synthase-2 -LRB- PHS-2 -RRB- mRNA by TCDD .
17982107	0	prostaglandin_endoperoxide_H_synthase_2	42,81	IL-1beta	30,38	prostaglandin endoperoxide H synthase 2	IL-1beta	5743	3553	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Jak2 dampens the induction by IL-1beta of prostaglandin_endoperoxide_H_synthase_2 expression in human orbital fibroblasts : evidence for divergent influence on the prostaglandin_E2 biosynthetic pathway .
7872783	0	prostaglandin_endoperoxide_synthase-1	24,61	cyclooxygenase-1	63,79	prostaglandin endoperoxide synthase-1	cyclooxygenase-1	19224(Tax:10090)	19224(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|dep|END_ENTITY	Selective inhibition of prostaglandin_endoperoxide_synthase-1 -LRB- cyclooxygenase-1 -RRB- by valerylsalicylic_acid .
8663219	0	prostaglandin_endoperoxide_synthase-2	27,64	PGS-2	66,71	prostaglandin endoperoxide synthase-2	PGS-2	29527(Tax:10116)	29527(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	An E-box region within the prostaglandin_endoperoxide_synthase-2 -LRB- PGS-2 -RRB- promoter is required for transcription in rat ovarian granulosa cells .
7594606	0	prostaglandin_endoperoxide_synthase-2	129,166	prostaglandin_D2	97,113	prostaglandin endoperoxide synthase-2	prostaglandin D2	19225(Tax:10090)	19215(Tax:10090)	Gene	Gene	generation|nmod|START_ENTITY generation|amod|END_ENTITY	IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin_D2 generation via prostaglandin_endoperoxide_synthase-2 .
10750035	0	prostaglandin_synthase_type-1	16,45	PGHS-1	47,53	prostaglandin synthase type-1	PGHS-1	443551(Tax:9940)	443551(Tax:9940)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of prostaglandin_synthase_type-1 -LRB- PGHS-1 -RRB- mRNA and prostaglandin_synthase_type-2 -LRB- PGHS-2 -RRB- mRNA in ovine myometrium and endometrium throughout gestation .
10750035	0	prostaglandin_synthase_type-2	64,93	PGHS-2	95,101	prostaglandin synthase type-2	PGHS-2	443460(Tax:9940)	443460(Tax:9940)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of prostaglandin_synthase_type-1 -LRB- PGHS-1 -RRB- mRNA and prostaglandin_synthase_type-2 -LRB- PGHS-2 -RRB- mRNA in ovine myometrium and endometrium throughout gestation .
21995456	0	prostaglandin_synthetase-2	29,55	COX-2	64,69	prostaglandin synthetase-2	COX-2	5743	4513	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the 3 ` UTR of the prostaglandin_synthetase-2 -LRB- PTGS-2 / COX-2 -RRB- gene in non-melanoma_skin_cancer after organ transplantation .
10484490	0	prostaglandin_transporter	17,42	PGT	43,46	prostaglandin transporter	PGT	24059(Tax:10090)	6578	Gene	Gene	cDNA|compound|START_ENTITY cDNA|compound|END_ENTITY	Cloning of mouse prostaglandin_transporter PGT cDNA : species-specific substrate affinities .
12002745	0	prostanoid_DP_receptor	71,93	haematopoietic_prostaglandin_D_synthase	21,60	prostanoid DP receptor	haematopoietic prostaglandin D synthase	5729	27306	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	New polymorphisms of haematopoietic_prostaglandin_D_synthase and human prostanoid_DP_receptor genes .
23973650	0	prostanoid_EP4_receptor	80,103	cyclooxygenase-2	13,29	prostanoid EP4 receptor	cyclooxygenase-2	5734	5743	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of cyclooxygenase-2 expression by prostaglandin_E2 stimulation of the prostanoid_EP4_receptor via coupling to Gai and transactivation of the epidermal_growth_factor_receptor in HCA-7 human colon_cancer cells .
23973650	0	prostanoid_EP4_receptor	80,103	epidermal_growth_factor_receptor	151,183	prostanoid EP4 receptor	epidermal growth factor receptor	5734	1956	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 expression by prostaglandin_E2 stimulation of the prostanoid_EP4_receptor via coupling to Gai and transactivation of the epidermal_growth_factor_receptor in HCA-7 human colon_cancer cells .
19911255	0	prostasin	17,26	Hepsin	0,6	prostasin	Hepsin	5652	3249	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Hepsin activates prostasin and cleaves the extracellular domain of the epidermal_growth_factor_receptor .
24898171	0	prostate-derived_Ets_factor	21,48	HOXB13	0,6	prostate-derived Ets factor	HOXB13	25803	10481	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	HOXB13 regulates the prostate-derived_Ets_factor : implications for prostate_cancer cell invasion .
15839913	0	prostate-specific_antigen	52,77	C-reactive_protein	0,18	prostate-specific antigen	C-reactive protein	354	1401	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	C-reactive_protein is significantly associated with prostate-specific_antigen and metastatic_disease in prostate_cancer .
16458609	0	prostate-specific_antigen	46,71	CD8	20,23	prostate-specific antigen	CD8	354	925	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Correlation between CD8 + T cells specific for prostate-specific_antigen and level of disease in patients with prostate_cancer .
12970746	0	prostate-specific_antigen	23,48	Interleukin-4	0,13	prostate-specific antigen	Interleukin-4	354	3565	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin-4 enhances prostate-specific_antigen expression by activation of the androgen_receptor and Akt pathway .
11909978	0	prostate-specific_antigen	21,46	NF-kappa_B	0,10	prostate-specific antigen	NF-kappa B	354	4790	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	NF-kappa_B activates prostate-specific_antigen expression and is upregulated in androgen-independent prostate_cancer .
10070886	0	prostate-specific_antigen	14,39	PSA	41,44	prostate-specific antigen	PSA	354	354	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of prostate-specific_antigen -LRB- PSA -RRB- correlates with poor response to tamoxifen therapy in recurrent breast_cancer .
10486959	0	prostate-specific_antigen	14,39	PSA	41,44	prostate-specific antigen	PSA	354	354	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of prostate-specific_antigen -LRB- PSA -RRB- membrane test assays for the forensic identification of seminal fluid .
11561687	0	prostate-specific_antigen	11,36	PSA	38,41	prostate-specific antigen	PSA	354	354	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Changes in prostate-specific_antigen -LRB- PSA -RRB- level correlate with growth inhibition of prostate_cancer cells treated in vitro with a novel anticancer drug , irofulven .
1379363	0	prostate-specific_antigen	23,48	PSA	50,53	prostate-specific antigen	PSA	354	354	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Hormonal regulation of prostate-specific_antigen -LRB- PSA -RRB- glycoprotein in the human prostatic_adenocarcinoma cell line , LNCaP .
14635070	0	prostate-specific_antigen	87,112	PSA	114,117	prostate-specific antigen	PSA	354	354	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Clinical features of patients who present with metastatic prostate_carcinoma and serum prostate-specific_antigen -LRB- PSA -RRB- levels < 10 ng/mL : the `` PSA negative '' patients .
18853950	0	prostate-specific_antigen	27,52	PSA	54,57	prostate-specific antigen	PSA	354	354	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The effect of sirolimus on prostate-specific_antigen -LRB- PSA -RRB- levels in male_renal_transplant_recipients_without_prostate_cancer .
22093091	0	prostate-specific_antigen	83,108	PSA	110,113	prostate-specific antigen	PSA	354	354	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Transperineal prostate biopsy detects significant cancer in patients with elevated prostate-specific_antigen _ -LRB- PSA -RRB- levels and previous negative transrectal biopsies .
22093144	0	prostate-specific_antigen	9,34	PSA	36,39	prostate-specific antigen	PSA	354	354	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Value of prostate-specific_antigen -LRB- PSA -RRB- mass ratio in the detection of prostate_cancer in men with PSA levels of < = 10 ng/mL .
8758241	0	prostate-specific_antigen	14,39	PSA	9,12	prostate-specific antigen	PSA	354	354	Gene	Gene	Value|appos|START_ENTITY Value|nmod|END_ENTITY	Value of PSA -LRB- prostate-specific_antigen -RRB- in the detection of prostate_cancer in patients with urological symptoms .
8647643	0	prostate-specific_antigen	65,90	Prostate-specific_antigen	0,25	prostate-specific antigen	Prostate-specific antigen	354	354	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Prostate-specific_antigen in breast cyst fluid : possible role of prostate-specific_antigen in hormone-dependent breast_cancer .
14680804	0	prostate-specific_antigen	59,84	TRPS1	26,31	prostate-specific antigen	TRPS1	354	7227	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The atypical GATA protein TRPS1 represses androgen-induced prostate-specific_antigen expression in LNCaP_prostate_cancer cells .
14744750	0	prostate-specific_antigen	71,96	insulin-like_growth_factor-I	6,34	prostate-specific antigen	insulin-like growth factor-I	354	3479	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Serum insulin-like_growth_factor-I is positively associated with serum prostate-specific_antigen in middle-aged men without evidence of prostate_cancer .
15994976	0	prostate-specific_antigen	59,84	interleukin-6	135,148	prostate-specific antigen	interleukin-6	354	3569	Gene	Gene	START_ENTITY|nmod|cells cells|acl|treated treated|xcomp|chronically chronically|advcl|END_ENTITY	p300 regulates androgen_receptor-independent expression of prostate-specific_antigen in prostate_cancer cells treated chronically with interleukin-6 .
21051589	0	prostate-specific_antigen	44,69	interleukin-6	20,33	prostate-specific antigen	interleukin-6	354	3569	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Mechanisms by which interleukin-6 regulates prostate-specific_antigen gene expression in prostate LNCaP carcinoma cells .
18602143	0	prostate-specific_antigen	14,39	junctional_adhesion_molecule_A	58,88	prostate-specific antigen	junctional adhesion molecule A	354	50848	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of prostate-specific_antigen expression by the junctional_adhesion_molecule_A .
15994976	0	prostate-specific_antigen	59,84	p300	0,4	prostate-specific antigen	p300	354	2033	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	p300 regulates androgen_receptor-independent expression of prostate-specific_antigen in prostate_cancer cells treated chronically with interleukin-6 .
19861512	0	prostate-specific_antigen	79,104	parathyroid_hormone	22,41	prostate-specific antigen	parathyroid hormone	354	5741	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	The relation of serum parathyroid_hormone and serum calcium to serum levels of prostate-specific_antigen : a population-based study .
26388370	0	prostate-specific_antigen	10,35	prostate-specific_antigen	51,76	prostate-specific antigen	prostate-specific antigen	354	354	Gene	Gene	detection|amod|START_ENTITY detection|nmod|END_ENTITY	Real-time prostate-specific_antigen detection with prostate-specific_antigen imprinted capacitive biosensors .
26388370	0	prostate-specific_antigen	10,35	prostate-specific_antigen	51,76	prostate-specific antigen	prostate-specific antigen	354	354	Gene	Gene	detection|amod|START_ENTITY detection|nmod|END_ENTITY	Real-time prostate-specific_antigen detection with prostate-specific_antigen imprinted capacitive biosensors .
26388370	0	prostate-specific_antigen	51,76	prostate-specific_antigen	10,35	prostate-specific antigen	prostate-specific antigen	354	354	Gene	Gene	detection|nmod|START_ENTITY detection|amod|END_ENTITY	Real-time prostate-specific_antigen detection with prostate-specific_antigen imprinted capacitive biosensors .
26388370	0	prostate-specific_antigen	51,76	prostate-specific_antigen	10,35	prostate-specific antigen	prostate-specific antigen	354	354	Gene	Gene	detection|nmod|START_ENTITY detection|amod|END_ENTITY	Real-time prostate-specific_antigen detection with prostate-specific_antigen imprinted capacitive biosensors .
8665956	0	prostate-specific_antigen	70,95	semenogelin_II	20,34	prostate-specific antigen	semenogelin II	354	6407	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of semenogelin_II and its molecular interaction with prostate-specific_antigen and protein_C_inhibitor .
10075006	0	prostate-specific_antigen	161,186	transforming_growth_factor_beta1	41,73	prostate-specific antigen	transforming growth factor beta1	354	7040	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|upregulation upregulation|nmod|END_ENTITY	Early castration-induced upregulation of transforming_growth_factor_beta1 and its receptors is associated with tumor cell apoptosis and a major decline in serum prostate-specific_antigen in prostate_cancer patients .
9815590	0	prostate-specific_antigen	112,137	transforming_growth_factor_beta1	55,87	prostate-specific antigen	transforming growth factor beta1	354	7040	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 13-cis-retinoic_acid and alpha-interferon on transforming_growth_factor_beta1 in patients with rising prostate-specific_antigen .
11350116	0	prostate-specific_membrane_antigen	34,68	FOLH1	75,80	prostate-specific membrane antigen	FOLH1	2346	2346	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A tissue-specific enhancer of the prostate-specific_membrane_antigen gene , FOLH1 .
8595888	0	prostate-specific_membrane_antigen	41,75	PSM	77,80	prostate-specific membrane antigen	PSM	2346	2346	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization and physical mapping of the prostate-specific_membrane_antigen -LRB- PSM -RRB- gene to human chromosome 11 .
14716746	0	prostate-specific_membrane_antigen	24,58	PSMA	60,64	prostate-specific membrane antigen	PSMA	2346	2346	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Comparative analysis of prostate-specific_membrane_antigen -LRB- PSMA -RRB- versus a prostate-specific_membrane_antigen-like gene .
18802790	0	prostate-specific_membrane_antigen	17,51	PSMA	53,57	prostate-specific membrane antigen	PSMA	2346	2346	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Heterogeneity of prostate-specific_membrane_antigen -LRB- PSMA -RRB- expression in prostate_carcinoma with distant metastasis .
20568777	0	prostate-specific_membrane_antigen	27,61	PSMA	63,67	prostate-specific membrane antigen	PSMA	2346	2346	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|appos|END_ENTITY	68Ga-labeled inhibitors of prostate-specific_membrane_antigen -LRB- PSMA -RRB- for imaging prostate_cancer .
22497258	0	prostate-specific_membrane_antigen	83,117	PSMA	119,123	prostate-specific membrane antigen	PSMA	2346	2346	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Structure-activity relationships of 2 ' ,5 ' - oligoadenylate analogue modifications of prostate-specific_membrane_antigen -LRB- PSMA -RRB- antagonists .
24425321	0	prostate-specific_membrane_antigen	33,67	PSMA	69,73	prostate-specific membrane antigen	PSMA	2346	2346	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Production of nanobodies against prostate-specific_membrane_antigen -LRB- PSMA -RRB- recognizing LnCaP cells .
26576996	0	prostate-specific_membrane_antigen	45,79	PSMA	81,85	prostate-specific membrane antigen	PSMA	2346	2346	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Alterations in androgen deprivation enhanced prostate-specific_membrane_antigen -LRB- PSMA -RRB- expression in prostate_cancer cells as a target for diagnostics and therapy .
10580145	0	prostate-specific_transglutaminase	65,99	TGM4	106,110	prostate-specific transglutaminase	TGM4	7047	7047	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An Sp1 binding site is essential for basal activity of the human prostate-specific_transglutaminase gene -LRB- TGM4 -RRB- promoter .
9721214	0	prostate-specific_transglutaminase	10,44	TGM4	51,55	prostate-specific transglutaminase	TGM4	7047	7047	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human prostate-specific_transglutaminase gene -LRB- TGM4 -RRB- : genomic organization , tissue-specific expression , and promoter characterization .
22766399	0	prostate_androgen-regulated_mucin-like_protein_1	47,95	Parm1	97,102	prostate androgen-regulated mucin-like protein 1	Parm1	25849	25849	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Murine expression and mutation analyses of the prostate_androgen-regulated_mucin-like_protein_1 -LRB- Parm1 -RRB- gene , a candidate for human epispadias .
20082875	0	prostate_apoptosis_response	14,41	Par-4	43,48	prostate apoptosis response	Par-4	5074	5074	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of prostate_apoptosis_response -LRB- Par-4 -RRB- is associated with progesterone_receptor in breast_cancer .
25135281	0	prostate_apoptosis_response-4	21,50	IDH1	82,86	prostate apoptosis response-4	IDH1	5074	3417	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The tumor suppressor prostate_apoptosis_response-4 -LRB- Par-4 -RRB- is regulated by mutant IDH1 and kills glioma stem cells .
21567071	0	prostate_apoptosis_response-4	61,90	Insulin-like_growth_factor-1	0,28	prostate apoptosis response-4	Insulin-like growth factor-1	5074	3479	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Insulin-like_growth_factor-1 and 17b-estradiol down-regulate prostate_apoptosis_response-4 expression in MCF-7 breast_cancer cells .
24282526	0	prostate_apoptosis_response_4	8,37	GRP78	58,63	prostate apoptosis response 4	GRP78	5074	3309	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of prostate_apoptosis_response_4 in translocation of GRP78 from the endoplasmic reticulum to the cell surface of trophoblastic cells .
17219052	0	prostate_apoptosis_response_protein_4	32,69	Par-4	71,76	prostate apoptosis response protein 4	Par-4	64513(Tax:10116)	64513(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of the expression of prostate_apoptosis_response_protein_4 -LRB- Par-4 -RRB- in rat granulosa cells .
11306358	0	prostate_cancer	46,61	Osteoprotegerin	0,15	osteoprotegerin	Osteoprotegerin	4982	4982	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Osteoprotegerin and rank_ligand expression in prostate_cancer .
14770085	0	prostate_specific_antigen	40,65	CD4	0,3	prostate specific antigen	CD4	354	920	Gene	Gene	recognition|nmod|START_ENTITY recognition|compound|END_ENTITY	CD4 and CD8 T-lymphocyte recognition of prostate_specific_antigen in granulomatous_prostatitis .
10188912	0	prostate_specific_antigen	51,76	KLK_3	44,49	prostate specific antigen	KLK 3	354	354	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	The promoter and the enhancer region of the KLK_3 -LRB- prostate_specific_antigen -RRB- gene is frequently mutated in breast_tumours and in breast_carcinoma cell lines .
11229650	0	prostate_specific_antigen	25,50	PSA	52,55	prostate specific antigen	PSA	354	354	Gene	Gene	increase|amod|START_ENTITY increase|appos|END_ENTITY	Tibia metastasis without prostate_specific_antigen -LRB- PSA -RRB- increase following radical vesiculo-prostatectomy .
11791186	0	prostate_specific_antigen	14,39	PSA	41,44	prostate specific antigen	PSA	354	354	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of prostate_specific_antigen -LRB- PSA -RRB- is negatively regulated by p53 .
15678849	0	prostate_specific_antigen	34,59	PSA	61,64	prostate specific antigen	PSA	354	354	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of prostate_specific_antigen -LRB- PSA -RRB- in benign and malignant_tumors of the prostate .
15751649	0	prostate_specific_antigen	80,105	PSA	107,110	prostate specific antigen	PSA	354	354	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Tumor markers in prostate_cancer -- clinical significance and future prospect of prostate_specific_antigen -LRB- PSA -RRB- -RSB- .
24573892	0	prostate_specific_antigen	9,34	PSA	36,39	prostate specific antigen	PSA	354	354	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Elevated prostate_specific_antigen -LRB- PSA -RRB- levels a risk factor for pathological hip_fracture in metastatic prostatic_carcinoma .
26506115	0	prostate_specific_antigen	19,44	PSA	46,49	prostate specific antigen	PSA	354	354	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	Clinical impact of prostate_specific_antigen -LRB- PSA -RRB- inter-assay variability on management of prostate_cancer .
7685140	0	prostate_specific_antigen	22,47	PSA	49,52	prostate specific antigen	PSA	354	354	Gene	Gene	Examination|nmod|START_ENTITY Examination|appos|END_ENTITY	-LSB- Examination of serum prostate_specific_antigen -LRB- PSA -RRB- in the mass screening for prostatic_diseases -RSB- .
9125863	0	prostate_specific_antigen	74,99	PSA	101,104	prostate specific antigen	PSA	354	354	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- A pilot study of mass screening program for prostatic_cancer by means of prostate_specific_antigen -LRB- PSA -RRB- filter paper method -RSB- .
9250498	0	prostate_specific_antigen	59,84	PSA	86,89	prostate specific antigen	PSA	354	354	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Diagnosis and follow-up of prostate_cancer patients using prostate_specific_antigen -LRB- PSA -RRB- -RSB- .
9772877	0	prostate_specific_antigen	13,38	PSA	69,72	prostate specific antigen	PSA	354	354	Gene	Gene	value|nmod|START_ENTITY value|dep|ratio ratio|compound|END_ENTITY	The value of prostate_specific_antigen -LRB- PSA -RRB- density and free : total PSA ratio in selecting patients with a normal digital rectal examination and intermediate total PSA levels for further investigation .
9872328	0	prostate_specific_antigen	48,73	PSA	75,78	prostate specific antigen	PSA	354	354	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Molecular and immunological analysis of genetic prostate_specific_antigen -LRB- PSA -RRB- vaccine .
20432434	0	prostate_specific_antigen	62,87	SRCAP	32,37	prostate specific antigen	SRCAP	354	10847	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dobj|expression	The chromatin remodeling factor SRCAP modulates expression of prostate_specific_antigen and cellular proliferation in prostate_cancer cells .
7527116	0	prostate_specific_antigen	24,49	alpha_1-antichymotrypsin	71,95	prostate specific antigen	alpha 1-antichymotrypsin	354	12	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|nmod|END_ENTITY	Serum concentrations of prostate_specific_antigen and its complex with alpha_1-antichymotrypsin before diagnosis of prostate_cancer .
17257635	0	prostate_specific_antigen	39,64	kallikrein-2_and_androgen_receptor	66,100	prostate specific antigen	kallikrein-2 and androgen receptor	354	367	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Is there an inter-relationship between prostate_specific_antigen , kallikrein-2_and_androgen_receptor gene polymorphisms with risk of prostate_cancer in north Indian population ?
11791186	0	prostate_specific_antigen	14,39	p53	73,76	prostate specific antigen	p53	354	7157	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of prostate_specific_antigen -LRB- PSA -RRB- is negatively regulated by p53 .
10751861	0	prostate_specific_antigen	10,35	prostate_specific_antigen	104,129	prostate specific antigen	prostate specific antigen	354	354	Gene	Gene	provides|nsubj|START_ENTITY provides|advcl|END_ENTITY	Complexed prostate_specific_antigen provides significant enhancement of specificity compared with total prostate_specific_antigen for detecting prostate_cancer .
10751861	0	prostate_specific_antigen	104,129	prostate_specific_antigen	10,35	prostate specific antigen	prostate specific antigen	354	354	Gene	Gene	provides|advcl|START_ENTITY provides|nsubj|END_ENTITY	Complexed prostate_specific_antigen provides significant enhancement of specificity compared with total prostate_specific_antigen for detecting prostate_cancer .
7504749	0	prostate_specific_antigen	21,46	prostate_specific_antigen	57,82	prostate specific antigen	prostate specific antigen	354	354	Gene	Gene	START_ENTITY|xcomp|using using|dobj|END_ENTITY	Measurement of serum prostate_specific_antigen using IMx prostate_specific_antigen assay .
7504749	0	prostate_specific_antigen	57,82	prostate_specific_antigen	21,46	prostate specific antigen	prostate specific antigen	354	354	Gene	Gene	using|dobj|START_ENTITY END_ENTITY|xcomp|using	Measurement of serum prostate_specific_antigen using IMx prostate_specific_antigen assay .
17725301	0	prostate_specific_membrane_antigen	68,102	Fab	47,50	prostate specific membrane antigen	Fab	2346	2187	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- Screening and characterization of human phage Fab antibody gene to prostate_specific_membrane_antigen -RSB- .
19242540	0	prostate_specific_membrane_antigen	4,38	IL-6	67,71	prostate specific membrane antigen	IL-6	2346	3569	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	The prostate_specific_membrane_antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways .
18076024	0	prostate_stem_cell_antigen	19,45	PSCA	47,51	prostate stem cell antigen	PSCA	8000	8000	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	The association of prostate_stem_cell_antigen -LRB- PSCA -RRB- mRNA expression and subsequent prostate_cancer risk in men with benign_prostatic_hyperplasia following transurethral resection of the prostate .
22536409	0	prostate_stem_cell_antigen	36,62	Yin_Yang_1	77,87	prostate stem cell antigen	Yin Yang 1	8000	7528	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Positive and negative regulation of prostate_stem_cell_antigen expression by Yin_Yang_1 in prostate epithelial cell lines .
17552366	0	prostate_transglutaminase	18,43	TGase-4	45,52	prostate transglutaminase	TGase-4	7047	7047	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the prostate_transglutaminase -LRB- TGase-4 -RRB- in prostate_cancer cells and its impact on the invasiveness of prostate_cancer .
15048720	0	prostein	63,71	CD8	38,41	prostein	CD8	85414	925	Gene	Gene	epitopes|nmod|START_ENTITY epitopes|nsubj|Identification Identification|nmod|cell cell|compound|END_ENTITY	Identification of naturally processed CD8 T cell epitopes from prostein , a prostate tissue-specific vaccine candidate .
22821757	0	prostein	25,33	SLC45A3	8,15	prostein	SLC45A3	85414	85414	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Loss of SLC45A3 protein -LRB- prostein -RRB- expression in prostate_cancer is associated with SLC45A3-ERG_gene_rearrangement and an unfavorable clinical course .
3350120	0	protamine_1	9,20	protamine_2	21,32	protamine 1	protamine 2	5619	5620	Gene	Gene	START_ENTITY|dep|ratios ratios|amod|END_ENTITY	Aberrant protamine_1 / protamine_2 ratios in sperm of infertile human males .
20667534	0	protamine_2	15,26	Protamine_1	0,11	protamine 2	Protamine 1	5620	5619	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|nmod|ratio	Protamine_1 to protamine_2 ratio correlates with dynamic aspects of DNA fragmentation in human sperm .
3350120	0	protamine_2	21,32	protamine_1	9,20	protamine 2	protamine 1	5620	5619	Gene	Gene	ratios|amod|START_ENTITY END_ENTITY|dep|ratios	Aberrant protamine_1 / protamine_2 ratios in sperm of infertile human males .
19263271	0	protease-activated-receptor_2	14,43	PAR-2	45,50	protease-activated-receptor 2	PAR-2	2150	2150	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of protease-activated-receptor_2 -LRB- PAR-2 -RRB- in human esophageal mucosa .
9105886	0	protease-activated_receptor	36,63	PAR-1	65,70	protease-activated receptor	PAR-1	25439(Tax:10116)	25439(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Pharmacological characterization of protease-activated_receptor -LRB- PAR-1 -RRB- in rat astrocytes .
18537828	0	protease-activated_receptor-1	18,47	EP2	131,134	protease-activated receptor-1	EP2	2149	5732	Gene	Gene	Downregulation|nmod|START_ENTITY mediated|nsubjpass|Downregulation mediated|nmod|END_ENTITY	Downregulation of protease-activated_receptor-1 in human lung fibroblasts is specifically mediated by the prostaglandin E receptor EP2 through cAMP elevation and protein kinase A .
24390664	0	protease-activated_receptor-1	39,68	PAR1	70,74	protease-activated receptor-1	PAR1	2149	2149	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Is there any diagnostic value of serum protease-activated_receptor-1 -LRB- PAR1 -RRB- levels on determination of epithelial_ovarian_carcinoma ?
23625915	0	protease-activated_receptor-1	44,73	STIM1	83,88	protease-activated receptor-1	STIM1	2149	6786	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|compound|END_ENTITY	Store-operated Ca2 + entry -LRB- SOCE -RRB- induced by protease-activated_receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38b mitogen-activated protein kinase .
24817013	0	protease-activated_receptor-1	63,92	ncRuPAR	0,7	protease-activated receptor-1	ncRuPAR	2149	100302746	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	ncRuPAR inhibits gastric_cancer progression by down-regulating protease-activated_receptor-1 .
15845904	0	protease-activated_receptor-1	102,131	thrombin	22,30	protease-activated receptor-1	thrombin	2149	2147	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubjpass|effect effect|nmod|END_ENTITY	Synergistic effect of thrombin on collagen-induced platelet_procoagulant activity is mediated through protease-activated_receptor-1 .
20412704	0	protease-activated_receptor-2	39,68	PAR-2	70,75	protease-activated receptor-2	PAR-2	2150	2150	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	The role of proteinase_3 -LRB- PR3 -RRB- and the protease-activated_receptor-2 -LRB- PAR-2 -RRB- pathway in dendritic cell -LRB- DC -RRB- maturation of human-DC-like monocytes and murine DC .
15765104	0	protease-activated_receptor-2	27,56	PAR2	117,121	protease-activated receptor-2	PAR2	2150	2150	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of a highly potent protease-activated_receptor-2 -LRB- PAR2 -RRB- activating peptide , -LSB- 3H -RSB- 2-furoyl-LIGRL-NH2 , to human PAR2 .
26742564	0	protease-activated_receptor-3	42,71	Thrombin	0,8	protease-activated receptor-3	Thrombin	2151	2147	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Thrombin stimulates insulin secretion via protease-activated_receptor-3 .
22860064	0	protease-activated_receptor_1	32,61	PAR1	63,67	protease-activated receptor 1	PAR1	558477(Tax:7955)	558477(Tax:7955)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Developmental role of zebrafish protease-activated_receptor_1 -LRB- PAR1 -RRB- in the cardio-vascular_system .
14597986	0	protease-activated_receptor_1	14,43	TRAP	124,128	protease-activated receptor 1	TRAP	2149	100187907	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of protease-activated_receptor_1 -LRB- PAR1 -RRB- on platelets and responsiveness to thrombin_receptor_activating_peptide -LRB- TRAP -RRB- during systemic inflammation in humans .
11023512	0	protease-activated_receptor_1	61,90	decay-accelerating_factor	13,38	protease-activated receptor 1	decay-accelerating factor	2149	1604	Gene	Gene	kinase|amod|START_ENTITY END_ENTITY|nmod|kinase	Induction of decay-accelerating_factor by thrombin through a protease-activated_receptor_1 and protein kinase C-dependent pathway protects vascular endothelial cells from complement-mediated injury .
22291441	0	protease-activated_receptor_1	20,49	hPar1	51,56	protease-activated receptor 1	hPar1	2149	2149	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of human protease-activated_receptor_1 -LRB- hPar1 -RRB- gene expression in breast_cancer by estrogen .
10669659	0	protease-activated_receptor_1	42,71	thrombin	23,31	protease-activated receptor 1	thrombin	2149	2147	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Protective effect of a thrombin receptor -LRB- protease-activated_receptor_1 -RRB- gene polymorphism toward venous thromboembolism .
10780327	0	protease-activated_receptor_1	92,121	thrombin	123,131	protease-activated receptor 1	thrombin	2149	2147	Gene	Gene	START_ENTITY|appos|receptor receptor|compound|END_ENTITY	Identification of a novel 33-kDa Ser/Thr kinase that phosphorylates the cytoplasmic tail of protease-activated_receptor_1 -LRB- thrombin receptor -RRB- in human platelets .
23204166	0	protease-activated_receptor_1	131,160	thrombin	108,116	protease-activated receptor 1	thrombin	2149	2147	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Enhanced effector function of CD8 -LRB- + -RRB- T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated_receptor_1 .
20118282	0	protease-activated_receptor_2	18,47	Insulin	0,7	protease-activated receptor 2	Insulin	14063(Tax:10090)	3630	Gene	Gene	signaling|amod|START_ENTITY modulates|dobj|signaling modulates|nsubj|END_ENTITY	Insulin modulates protease-activated_receptor_2 signaling : implications for the innate immune response .
17203209	0	protease-activated_receptor_2	29,58	Interleukin-8	0,13	protease-activated receptor 2	Interleukin-8	2150	3576	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Interleukin-8 production via protease-activated_receptor_2 in human esophageal epithelial cells .
21072196	0	protease-activated_receptor_2	37,66	PAR2	68,72	protease-activated receptor 2	PAR2	2150	2150	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Profiling gene expression induced by protease-activated_receptor_2 -LRB- PAR2 -RRB- activation in human kidney cells .
26631441	0	protease-activated_receptor_2	64,93	PAR2	95,99	protease-activated receptor 2	PAR2	14063(Tax:10090)	14063(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated_receptor_2 -LRB- PAR2 -RRB- antagonists .
22460072	0	protease-activated_receptor_2	66,95	TH2	107,110	protease-activated receptor 2	TH2	14063(Tax:10090)	15111(Tax:10090)	Gene	Gene	immunity|amod|START_ENTITY immunity|compound|END_ENTITY	Naive T cells sense the cysteine protease allergen papain through protease-activated_receptor_2 and propel TH2 immunity .
18212111	0	protease-activated_receptor_2	81,110	interleukin-8	55,68	protease-activated receptor 2	interleukin-8	2150	3576	Gene	Gene	mediated|advcl|START_ENTITY mediated|nsubj|Effect Effect|nmod|macrolides macrolides|nmod|production production|nmod|END_ENTITY	Effect of 14-membered-ring macrolides on production of interleukin-8 mediated by protease-activated_receptor_2 in human keratinocytes .
23475608	0	protease-activated_receptor_2	161,190	monocyte_chemoattractant_protein-1	101,135	protease-activated receptor 2	monocyte chemoattractant protein-1	2150	6347	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|nmod|END_ENTITY	Thromboxane_A2_receptor-mediated release of matrix_metalloproteinase-1 -LRB- MMP-1 -RRB- induces expression of monocyte_chemoattractant_protein-1 -LRB- MCP-1 -RRB- by activation of protease-activated_receptor_2 -LRB- PAR2 -RRB- in A549 human lung_adenocarcinoma cells .
16439712	0	protease-activated_receptor_2	25,54	tumor_necrosis_factor-alpha	59,86	protease-activated receptor 2	tumor necrosis factor-alpha	2150	7124	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Proangiogenic effects of protease-activated_receptor_2 are tumor_necrosis_factor-alpha and consecutively Tie2 dependent .
14726524	0	protease-activated_receptors_2_and_4	31,67	Trypsin_IV	0,10	protease-activated receptors 2 and 4	Trypsin IV	2150;9002	5646	Gene	Gene	agonist|nmod|START_ENTITY END_ENTITY|appos|agonist	Trypsin_IV , a novel agonist of protease-activated_receptors_2_and_4 .
15911126	0	protease_M	27,37	neurosin	38,46	protease M	neurosin	19144(Tax:10090)	19144(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Differential expression of protease_M / neurosin in oligodendrocytes and their progenitors in an animal model of multiple_sclerosis .
12176812	0	protease_activated_receptor-1	51,80	RANTES	31,37	protease activated receptor-1	RANTES	2149	6352	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Thrombin-induced expression of RANTES mRNA through protease_activated_receptor-1 in human synovial fibroblasts .
12586611	0	protease_activated_receptor-1	141,170	endothelial_protein_C_receptor	92,122	protease activated receptor-1	endothelial protein C receptor	2149	10544	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Activated_protein_C alters cytosolic calcium flux in human brain endothelium via binding to endothelial_protein_C_receptor and activation of protease_activated_receptor-1 .
11828045	0	protease_activated_receptor-2	14,43	PAR-2	45,50	protease activated receptor-2	PAR-2	2150	2150	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of protease_activated_receptor-2 -LRB- PAR-2 -RRB- in central airways of smokers and non-smokers .
16425301	0	protease_activated_receptor-2	14,43	PAR-2	45,50	protease activated receptor-2	PAR-2	2150	2150	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of protease_activated_receptor-2 -LRB- PAR-2 -RRB- in gastric_cancer .
25176330	0	protease_activated_receptor_4	33,62	PAR-4	64,69	protease activated receptor 4	PAR-4	9002	9002	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Substituted indoles as selective protease_activated_receptor_4 -LRB- PAR-4 -RRB- antagonists : Discovery and SAR of ML354 .
25138159	0	protease_nexin-1	70,86	PN-1	88,92	protease nexin-1	PN-1	5270	5270	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease_nexin-1 -LRB- PN-1 -RRB- inhibition .
16797167	0	protease_nexin-1	22,38	Serpin	2,8	protease nexin-1	Serpin	446824(Tax:8355)	373636(Tax:8355)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A Serpin family gene , protease_nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos .
12379479	0	proteasome_component_C8	44,67	Egr-1	14,19	proteasome component C8	Egr-1	5684	1958	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of Egr-1 by association with the proteasome_component_C8 .
9800328	0	proteasome_subunit_A4	12,33	PSMA4	35,40	proteasome subunit A4	PSMA4	397058(Tax:9823)	397058(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The porcine proteasome_subunit_A4 -LRB- PSMA4 -RRB- gene : isolation of a partial cDNA , linkage and physical mapping .
21256111	0	proteasome_subunit_alpha_type_7	37,68	Calcineurin_B	0,13	proteasome subunit alpha type 7	Calcineurin B	5688	5534	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Calcineurin_B subunit interacts with proteasome_subunit_alpha_type_7 and represses hypoxia-inducible_factor-1a activity via the proteasome pathway .
21256111	0	proteasome_subunit_alpha_type_7	37,68	hypoxia-inducible_factor-1a	83,110	proteasome subunit alpha type 7	hypoxia-inducible factor-1a	5688	3091	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Calcineurin_B subunit interacts with proteasome_subunit_alpha_type_7 and represses hypoxia-inducible_factor-1a activity via the proteasome pathway .
21098669	0	proteasome_subunit_beta-type_8	47,77	PSMB8	84,89	proteasome subunit beta-type 8	PSMB8	100049532(Tax:8090)	100049532(Tax:8090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transspecies dimorphic allelic lineages of the proteasome_subunit_beta-type_8 gene -LRB- PSMB8 -RRB- in the teleost genus Oryzias .
18565852	0	proteasome_subunit_beta5	42,66	PSMB5	68,73	proteasome subunit beta5	PSMB5	5693	5693	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular basis of bortezomib resistance : proteasome_subunit_beta5 -LRB- PSMB5 -RRB- gene mutation and overexpression of PSMB5 protein .
16646031	0	proteasome_subunit_beta5i	37,62	LMP7	64,68	proteasome subunit beta5i	LMP7	5696	5696	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|END_ENTITY	Tissue-specific up-regulation of the proteasome_subunit_beta5i -LRB- LMP7 -RRB- in Sj gren 's _ syndrome .
22322674	0	proteasome_subunit_beta_type-8	42,72	PSMB8	74,79	proteasome subunit beta type-8	PSMB8	399439(Tax:8355)	399439(Tax:8355)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Highly divergent dimorphic alleles of the proteasome_subunit_beta_type-8 -LRB- PSMB8 -RRB- gene of the bichir Polypterus senegalus : implication for evolution of the PSMB8 gene of jawed vertebrates .
22491037	0	proteasome_subunit_beta_type_8	39,69	PSMB8	71,76	proteasome subunit beta type 8	PSMB8	550488(Tax:7955)	550488(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Long-lived dichotomous lineages of the proteasome_subunit_beta_type_8 -LRB- PSMB8 -RRB- gene surviving more than 500 million years as alleles or paralogs .
9367687	0	proteasome_subunit_lmp10	75,99	Psmb10	101,107	proteasome subunit lmp10	Psmb10	19171(Tax:10090)	19171(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	DNA sequence , chromosomal localization , and tissue expression of the mouse proteasome_subunit_lmp10 -LRB- Psmb10 -RRB- gene .
10667419	0	protectin	24,33	CD59	35,39	protectin	CD59	966	966	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Decreased expression of protectin -LRB- CD59 -RRB- in gut epithelium in ulcerative_colitis and Crohn 's _ disease .
10958054	0	protectin	17,26	CD59	28,32	protectin	CD59	966	966	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Emerging role of protectin -LRB- CD59 -RRB- in humoral immunotherapy of solid malignancies .
11056001	0	protectin	18,27	CD59	29,33	protectin	CD59	966	966	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of protectin -LRB- CD59 -RRB- down-modulates the susceptibility of human melanoma cells to homologous complement .
7538980	0	protectin	14,23	CD59	25,29	protectin	CD59	966	966	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of protectin -LRB- CD59 -RRB- in human melanoma and its functional role in cell - and complement-mediated cytotoxicity .
12125076	0	protein-L-isoaspartyl_methyltransferase	25,64	PIMT	66,70	protein-L-isoaspartyl methyltransferase	PIMT	18537(Tax:10090)	18537(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Adenoviral expression of protein-L-isoaspartyl_methyltransferase -LRB- PIMT -RRB- partially attenuates the biochemical changes in PIMT-deficient mice .
21697082	0	protein-arginine_methyltransferase_I	42,78	PRMT1	80,85	protein-arginine methyltransferase I	PRMT1	3276	3276	Gene	Gene	product|compound|START_ENTITY product|appos|END_ENTITY	Investigation of the molecular origins of protein-arginine_methyltransferase_I -LRB- PRMT1 -RRB- product specificity reveals a role for two conserved methionine residues .
15668243	0	protein-associated_splicing_factor	43,77	progesterone_receptor	112,133	protein-associated splicing factor	progesterone receptor	6421	5241	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of the protein-associated_splicing_factor as a negative co-regulator of the progesterone_receptor .
20562109	0	protein-disulfide_isomerase	62,89	Ero1alpha	0,9	protein-disulfide isomerase	Ero1alpha	64714	30001	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Ero1alpha is expressed on blood platelets in association with protein-disulfide_isomerase and contributes to redox-controlled remodeling of alphaIIbbeta3 .
8102801	0	protein-tyrosine-phosphatase	55,83	Epidermal_growth_factor	0,23	protein-tyrosine-phosphatase	Epidermal growth factor	26191	1950	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates substrate-selective protein-tyrosine-phosphatase activity .
11278933	0	protein-tyrosine_phosphatase	54,82	ATF-7	0,5	protein-tyrosine phosphatase	ATF-7	26191	11016	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ATF-7 , a novel bZIP protein , interacts with the PRL-1 protein-tyrosine_phosphatase .
21102485	0	protein-tyrosine_phosphatase-1B	41,72	PTP1B	74,79	protein-tyrosine phosphatase-1B	PTP1B	24697(Tax:10116)	24697(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Chronic ethanol consumption up-regulates protein-tyrosine_phosphatase-1B -LRB- PTP1B -RRB- expression in rat skeletal muscle .
21849469	0	protein-tyrosine_phosphatase_1B	11,42	HER2/Neu	93,101	protein-tyrosine phosphatase 1B	HER2/Neu	19246(Tax:10090)	13866(Tax:10090)	Gene	Gene	contributes|nsubj|START_ENTITY contributes|nmod|END_ENTITY	Epithelial protein-tyrosine_phosphatase_1B contributes to the induction of mammary_tumors by HER2/Neu but is not essential for tumor maintenance .
8702859	0	protein-tyrosine_phosphatase_1D	44,75	GRB2	120,124	protein-tyrosine phosphatase 1D	GRB2	5781	2885	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Epidermal_growth_factor induces coupling of protein-tyrosine_phosphatase_1D to GRB2 via the COOH-terminal SH3 domain of GRB2 .
10092676	0	protein-tyrosine_phosphatase_PEST	42,75	Hic-5	0,5	protein-tyrosine phosphatase PEST	Hic-5	5782	7041	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Hic-5 , a paxillin homologue , binds to the protein-tyrosine_phosphatase_PEST -LRB- PTP-PEST -RRB- through its LIM 3 domain .
18568953	0	protein-zero_related	36,56	PZR	58,61	protein-zero related	PZR	9019	9019	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation and localization of protein-zero_related -LRB- PZR -RRB- in cultured endothelial cells .
16522789	0	protein_C	36,45	FoxA2	0,5	protein C	FoxA2	25268(Tax:10116)	25099(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|amod|END_ENTITY	FoxA2 involvement in suppression of protein_C , an outcome predictor in experimental sepsis .
11140943	0	protein_C	62,71	PROC	73,77	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of an intronic regulatory element in the human protein_C -LRB- PROC -RRB- gene .
1511988	0	protein_C	44,53	PROC	55,59	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel homozygous missense mutation in the protein_C -LRB- PROC -RRB- gene causing recurrent venous_thrombosis .
1511989	0	protein_C	51,60	PROC	62,66	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two different missense mutations at Arg 178 of the protein_C -LRB- PROC -RRB- gene causing recurrent venous_thrombosis .
24115609	0	protein_C	20,29	PROC	36,40	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in protein_C gene -LRB- PROC -RRB- causing severe phenotype in neonatal period .
3356168	0	protein_C	24,33	PROC	40,44	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human protein_C gene -LRB- PROC -RRB- to chromosome region 2q14 -- q21 by in situ hybridization .
7605880	0	protein_C	29,38	PROC	40,44	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Three novel mutations in the protein_C -LRB- PROC -RRB- gene causing venous_thrombosis .
7841323	0	protein_C	48,57	PROC	59,63	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A homozygous deletion/insertion mutation in the protein_C -LRB- PROC -RRB- gene causing neonatal Purpura fulminans : prenatal diagnosis in an at-risk pregnancy .
8462980	0	protein_C	33,42	PROC	44,48	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel nonsense mutation in the protein_C -LRB- PROC -RRB- gene -LRB- Trp-29 -- > term -RRB- causing recurrent venous_thrombosis .
8499568	0	protein_C	44,53	PROC	55,59	protein C	PROC	5624	5624	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A Gla domain mutation -LRB- Arg_15 -- > Trp -RRB- in the protein_C -LRB- PROC -RRB- gene causing type 2 protein_C_deficiency and recurrent venous_thrombosis .
2752479	0	protein_C	50,59	antithrombin_III	22,38	protein C	antithrombin III	5624	462	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of antithrombin_III , activated protein_C and heparin on the inhibition of the tissue thromboplastin-mediated coagulation .
9649198	0	protein_C	41,50	beta2-glycoprotein_I	55,75	protein C	beta2-glycoprotein I	5624	350	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of anticardiolipin antibodies to protein_C via beta2-glycoprotein_I -LRB- beta2-GPI -RRB- : a possible mechanism in the inhibitory effect of antiphospholipid antibodies on the protein_C system .
8950780	0	protein_C	153,162	epidermal_growth_factor	104,127	protein C	epidermal growth factor	5624	1950	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Functional consequences of mutations in amino_acid residues that stabilize calcium binding to the first epidermal_growth_factor homology domain of human protein_C .
9616153	0	protein_C	20,29	factor_Xa	33,42	protein C	factor Xa	5624	2159	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Rapid activation of protein_C by factor_Xa and thrombin in the presence of polyanionic compounds .
7881411	0	protein_C	68,77	hepatocyte_nuclear_factor_1	33,60	protein C	hepatocyte nuclear factor 1	5624	6927	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Disruption of a binding site for hepatocyte_nuclear_factor_1 in the protein_C gene promoter is associated with hereditary_thrombophilia .
8091390	0	protein_C	37,46	plasmin	50,57	protein C	plasmin	5554	5340	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation and inactivation of human protein_C by plasmin .
7521127	0	protein_C_inhibitor	25,44	acrosin	14,21	protein C inhibitor	acrosin	5104	49	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acrosin by protein_C_inhibitor and localization of protein_C_inhibitor to spermatozoa .
7521127	0	protein_C_inhibitor	65,84	acrosin	14,21	protein C inhibitor	acrosin	5104	49	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acrosin by protein_C_inhibitor and localization of protein_C_inhibitor to spermatozoa .
10456457	0	protein_C_inhibitor	120,139	anticoagulant_protein_C	52,75	protein C inhibitor	anticoagulant protein C	5104	5624	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of Lys 62 -LRB- 217 -RRB- and Lys 63 -LRB- 218 -RRB- of human anticoagulant_protein_C in heparin stimulation of inhibition by the protein_C_inhibitor .
7521127	0	protein_C_inhibitor	25,44	protein_C_inhibitor	65,84	protein C inhibitor	protein C inhibitor	5104	5104	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acrosin by protein_C_inhibitor and localization of protein_C_inhibitor to spermatozoa .
7521127	0	protein_C_inhibitor	65,84	protein_C_inhibitor	25,44	protein C inhibitor	protein C inhibitor	5104	5104	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of acrosin by protein_C_inhibitor and localization of protein_C_inhibitor to spermatozoa .
18703418	0	protein_D	19,28	CRISP1	56,62	protein D	CRISP1	64827(Tax:10116)	64827(Tax:10116)	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the protein_D and protein E forms of rat CRISP1 with epididymal sperm .
24585933	0	protein_D	86,95	Leukocyte-associated_Ig-like_receptor-1	0,39	protein D	Leukocyte-associated Ig-like receptor-1	10202	3903	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Leukocyte-associated_Ig-like_receptor-1 is a novel inhibitory receptor for surfactant protein_D .
22288595	0	protein_D	11,20	monocyte_chemoattractant_protein-1	57,91	protein D	monocyte chemoattractant protein-1	10202	6347	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Surfactant protein_D inhibits lipopolysaccharide-induced monocyte_chemoattractant_protein-1 expression in human renal tubular epithelial cells : implication for tubulointerstitial fibrosis .
1837850	0	protein_F1	24,34	GAP-43	36,42	protein F1	GAP-43	29423(Tax:10116)	29423(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Selective expression of protein_F1 / -LRB- GAP-43 -RRB- mRNA in pyramidal but not granule cells of the hippocampus .
2945554	0	protein_I	34,43	phospholipase_A2	14,30	protein I	phospholipase A2	282689(Tax:9913)	104974671	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of phospholipase_A2 by protein_I .
23684010	0	protein_O-fucosyltransferase_1	30,60	POFUT1	13,19	protein O-fucosyltransferase 1	POFUT1	403029(Tax:7955)	403029(Tax:7955)	Gene	Gene	Mutations|amod|START_ENTITY Mutations|nmod|END_ENTITY	Mutations in POFUT1 , encoding protein_O-fucosyltransferase_1 , cause generalized Dowling-Degos_disease .
24387993	0	protein_O-glucosyltransferase_1	31,62	POGLUT1	13,20	protein O-glucosyltransferase 1	POGLUT1	56983	56983	Gene	Gene	Mutations|amod|START_ENTITY Mutations|nmod|END_ENTITY	Mutations in POGLUT1 , encoding protein_O-glucosyltransferase_1 , cause autosomal-dominant Dowling-Degos_disease .
7579448	0	protein_S_alpha	39,54	PROS1	56,61	protein S alpha	PROS1	5627	5627	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The Ser_460_to_Pro substitution of the protein_S_alpha -LRB- PROS1 -RRB- gene is a frequent mutation associated with free protein S -LRB- type IIa -RRB- deficiency .
12529443	0	protein_arginine_N-methyltransferase_1	54,92	RNA_binding_protein	6,25	protein arginine N-methyltransferase 1	RNA binding protein	3276	5940	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Sam68 RNA_binding_protein is an in vivo substrate for protein_arginine_N-methyltransferase_1 .
26482848	0	protein_arginine_N-methyltransferase_5	18,56	RASSF1A	130,137	protein arginine N-methyltransferase 5	RASSF1A	10419	11186	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of protein_arginine_N-methyltransferase_5 -LRB- PRMT5 -RRB- as a novel interacting protein with the tumor suppressor protein RASSF1A .
26228443	0	protein_arginine_methyltransferase-5	70,106	PRMT5	108,113	protein arginine methyltransferase-5	PRMT5	480242(Tax:9615)	480242(Tax:9615)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
26294260	0	protein_arginine_methyltransferase-5	70,106	PRMT5	108,113	protein arginine methyltransferase-5	PRMT5	480242(Tax:9615)	480242(Tax:9615)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Species differences in metabolism of EPZ015666 , an oxetane-containing protein_arginine_methyltransferase-5 -LRB- PRMT5 -RRB- inhibitor .
19144646	0	protein_arginine_methyltransferase_1	76,112	pregnane_X_receptor	53,72	protein arginine methyltransferase 1	pregnane X receptor	3276	8856	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of transcriptional activity of pregnane_X_receptor by protein_arginine_methyltransferase_1 .
18347060	0	protein_arginine_methyltransferase_5	31,67	AJUBA	16,21	protein arginine methyltransferase 5	AJUBA	27374(Tax:10090)	16475(Tax:10090)	Gene	Gene	recruits|xcomp|START_ENTITY recruits|nsubj|END_ENTITY	The LIM protein AJUBA recruits protein_arginine_methyltransferase_5 to mediate SNAIL-dependent transcriptional repression .
15654770	0	protein_arginine_methyltransferase_5	64,100	IL-2	31,35	protein arginine methyltransferase 5	IL-2	10419	3558	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|compound|END_ENTITY	Arginine methylation regulates IL-2 gene expression : a role for protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- .
23048031	0	protein_arginine_methyltransferase_5	67,103	positive_regulatory_domain_4	21,49	protein arginine methyltransferase 5	positive regulatory domain 4	10419	11108	Gene	Gene	recruits|dobj|START_ENTITY recruits|nsubj|END_ENTITY	Transcription factor positive_regulatory_domain_4 -LRB- PRDM4 -RRB- recruits protein_arginine_methyltransferase_5 -LRB- PRMT5 -RRB- to mediate histone arginine methylation and control neural stem cell proliferation and differentiation .
17512914	0	protein_arginine_methyltransferase_8	34,70	PRMT8	72,77	protein arginine methyltransferase 8	PRMT8	381813(Tax:10090)	381813(Tax:10090)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Specific regional distribution of protein_arginine_methyltransferase_8 -LRB- PRMT8 -RRB- in the mouse brain .
17925405	0	protein_arginine_methyltransferase_8	14,50	PRMT8	52,57	protein arginine methyltransferase 8	PRMT8	56341	56341	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regulation of protein_arginine_methyltransferase_8 -LRB- PRMT8 -RRB- activity by its N-terminal domain .
22459602	0	protein_disulfide-isomerase	100,127	FUS	7,10	protein disulfide-isomerase	FUS	64714	2521	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Mutant FUS induces endoplasmic_reticulum_stress in amyotrophic_lateral_sclerosis and interacts with protein_disulfide-isomerase .
15845382	0	protein_disulfide_isomerase	29,56	ERp57	0,5	protein disulfide isomerase	ERp57	281373(Tax:9913)	281803(Tax:9913)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	ERp57 binds competitively to protein_disulfide_isomerase and calreticulin .
16740484	0	protein_disulfide_isomerase	25,52	ERp57	114,119	protein disulfide isomerase	ERp57	64714	2923	Gene	Gene	activity|compound|START_ENTITY role|nmod|activity role|dep|evidence evidence|nmod|participation participation|nmod|END_ENTITY	A role for sperm surface protein_disulfide_isomerase activity in gamete fusion : evidence for the participation of ERp57 .
23376309	0	protein_disulfide_isomerase	26,53	PDI	55,58	protein disulfide isomerase	PDI	64714	64714	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of radiolabeled protein_disulfide_isomerase -LRB- PDI -RRB- inhibitors as new potential PET agents for imaging of the enzyme PDI in neurological_disorders and cancer .
8188714	0	protein_disulfide_isomerase	13,40	PDI	42,45	protein disulfide isomerase	PDI	64714	64714	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of protein_disulfide_isomerase -LRB- PDI -RRB- on antibody folding in vitro .
8537405	0	protein_disulfide_isomerase	33,60	calreticulin	15,27	protein disulfide isomerase	calreticulin	64714	811	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of calreticulin with protein_disulfide_isomerase .
21299467	0	protein_disulfide_isomerase	146,173	transporter_associated_with_antigen_processing	42,88	protein disulfide isomerase	transporter associated with antigen processing	64714	6890	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Redox-regulated peptide transfer from the transporter_associated_with_antigen_processing to major histocompatibility complex class I molecules by protein_disulfide_isomerase .
19747560	0	protein_disulfide_isomerase_associated_3	29,69	PDIA3	71,76	protein disulfide isomerase associated 3	PDIA3	100316863(Tax:8030)	100316863(Tax:8030)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Stress-induced expression of protein_disulfide_isomerase_associated_3 -LRB- PDIA3 -RRB- in Atlantic_salmon -LRB- Salmo_salar L. -RRB- .
8687406	0	protein_disulphide_isomerase	30,58	ERp60	0,5	protein disulphide isomerase	ERp60	5034	171423	Gene	Gene	substitute|nmod|START_ENTITY substitute|nsubj|END_ENTITY	ERp60 does not substitute for protein_disulphide_isomerase as the beta-subunit of prolyl 4-hydroxylase .
22969086	0	protein_inhibitor_of_activated_STAT1	11,47	PIAS1	49,54	protein inhibitor of activated STAT1	PIAS1	56469(Tax:10090)	56469(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for protein_inhibitor_of_activated_STAT1 -LRB- PIAS1 -RRB- in lipogenic regulation through SUMOylation-independent suppression of liver X receptors .
22210188	0	protein_inhibitor_of_activated_STAT_2	15,52	PIAS2	54,59	protein inhibitor of activated STAT 2	PIAS2	9063	9063	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of protein_inhibitor_of_activated_STAT_2 -LRB- PIAS2 -RRB- with receptor_of_activated_C_kinase_1 , RACK1 .
22210188	0	protein_inhibitor_of_activated_STAT_2	15,52	receptor_of_activated_C_kinase_1	66,98	protein inhibitor of activated STAT 2	receptor of activated C kinase 1	9063	10399	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of protein_inhibitor_of_activated_STAT_2 -LRB- PIAS2 -RRB- with receptor_of_activated_C_kinase_1 , RACK1 .
11788578	0	protein_inhibitor_of_activated_Stat1	21,57	p53	14,17	protein inhibitor of activated Stat1	p53	8554	7157	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of p53 by protein_inhibitor_of_activated_Stat1 -LRB- PIAS1 -RRB- .
12578970	0	protein_interacting_with_C-kinase-1	109,144	acid-sensing_ion_channel-1	53,79	protein interacting with C-kinase-1	acid-sensing ion channel-1	9463	41	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|phosphorylation phosphorylation|nmod|END_ENTITY	cAMP-dependent protein kinase phosphorylation of the acid-sensing_ion_channel-1 regulates its binding to the protein_interacting_with_C-kinase-1 .
11802773	0	protein_interacting_with_C_kinase_1	43,78	PICK1	36,41	protein interacting with C kinase 1	PICK1	9463	9463	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of the synaptic protein PICK1 -LRB- protein_interacting_with_C_kinase_1 -RRB- with the non-voltage gated sodium channels BNC1 -LRB- brain Na + channel 1 -RRB- and ASIC -LRB- acid-sensing_ion_channel -RRB- .
11485312	0	protein_kinase	14,28	CKII	29,33	protein kinase	CKII	1022	1457	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of protein_kinase CKII by direct interaction with the C-terminal region of p47 -LRB- phox -RRB- .
20510015	0	protein_kinase	50,64	CKII	65,69	protein kinase	CKII	1022	1457	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Capsaicin , a component of red peppers , stimulates protein_kinase CKII activity .
7735325	0	protein_kinase	14,28	CKII	29,33	protein kinase	CKII	1022	1457	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of protein_kinase CKII during the cell division cycle .
10417823	0	protein_kinase	26,40	Melk	14,18	protein kinase	Melk	53859(Tax:10090)	17279(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Melk , a new protein_kinase , during early mouse development .
23139271	0	protein_kinase	45,59	connective_tissue_growth_factor	10,41	protein kinase	connective tissue growth factor	1022	1490	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of connective_tissue_growth_factor on protein_kinase expression and activity in human corneal fibroblasts .
9244377	0	protein_kinase	15,29	insulin_receptor	37,53	protein kinase	insulin receptor	64030(Tax:10116)	24954(Tax:10116)	Gene	Gene	CK2|amod|START_ENTITY CK2|nmod|preparations preparations|compound|END_ENTITY	Substrates for protein_kinase CK2 in insulin_receptor preparations from rat liver membranes : identification of a 210-kDa protein substrate as the dimeric form of endoplasmin .
12193414	0	protein_kinase-C	100,116	IGFBP-4	165,172	protein kinase-C	IGFBP-4	24681(Tax:10116)	360622(Tax:10116)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	Regulation of granulosa cell-derived insulin-like growth factor binding proteins -LRB- IGFBPs -RRB- : role for protein_kinase-C in the pre - and posttranslational modulation of IGFBP-4 and IGFBP-5 .
1379255	0	protein_kinase-C	8,24	insulin-like_growth_factor-binding_protein-1	42,86	protein kinase-C	insulin-like growth factor-binding protein-1	112476	3484	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|production production|amod|END_ENTITY	Role of protein_kinase-C in regulation of insulin-like_growth_factor-binding_protein-1 production by HepG2 cells .
1727720	0	protein_kinase-C	4,20	parathyroid_hormone	46,65	protein kinase-C	parathyroid hormone	112476	5741	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	The protein_kinase-C activation domain of the parathyroid_hormone .
11907174	0	protein_kinase_A	73,89	PKA	91,94	protein kinase A	PKA	25636(Tax:10116)	25636(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Differential effects of haloperidol and clozapine on -LSB- -LRB- 3 -RRB- H -RSB- cAMP binding , protein_kinase_A -LRB- PKA -RRB- activity , and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain .
9698155	0	protein_kinase_A	11,27	PKIalpha	39,47	protein kinase A	PKIalpha	25636(Tax:10116)	114906(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Endogenous protein_kinase_A inhibitor -LRB- PKIalpha -RRB- modulates synaptic activity .
16610234	0	protein_kinase_A	86,102	Parathyroid_hormone	0,19	protein kinase A	Parathyroid hormone	25636(Tax:10116)	24694(Tax:10116)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Parathyroid_hormone regulates osterix and Runx2 mRNA expression predominantly through protein_kinase_A signaling in osteoblast-like cells .
11937500	0	protein_kinase_A	11,27	cystic_fibrosis_transmembrane_conductance_regulator	60,111	protein kinase A	cystic fibrosis transmembrane conductance regulator	25636(Tax:10116)	24255(Tax:10116)	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Reciprocal protein_kinase_A regulatory interactions between cystic_fibrosis_transmembrane_conductance_regulator and Na + / H + exchanger isoform 3 in a renal polarized epithelial cell model .
15634677	0	protein_kinase_A	41,57	moesin	96,102	protein kinase A	moesin	25636(Tax:10116)	81521(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Chloride conductance is required for the protein_kinase_A and Rac1-dependent phosphorylation of moesin at Thr-558 by KCl in PC12 cells .
16463401	0	protein_kinase_A	57,73	serotonin_transporter	23,44	protein kinase A	serotonin transporter	25636(Tax:10116)	25553(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	In vitro regulation of serotonin_transporter activity by protein_kinase_A and nicotinic acetylcholine receptors in the prefrontal cortex of rats .
8536719	0	protein_kinase_A	110,126	steroidogenic_acute_regulatory_protein	159,197	protein kinase A	steroidogenic acute regulatory protein	25636(Tax:10116)	25557(Tax:10116)	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Diethylumbelliferyl_phosphate inhibits steroidogenesis by interfering with a long-lived factor acting between protein_kinase_A activation and induction of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- .
19818097	0	protein_kinase_A_RIIa	29,50	PRKAR2A	52,59	protein kinase A RIIa	PRKAR2A	5576	5576	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic modulation of the protein_kinase_A_RIIa -LRB- PRKAR2A -RRB- gene by histone_deacetylases_1_and_2 in human smooth muscle cells .
15723830	0	protein_kinase_A_catalytic_subunit_beta	18,57	p73	88,91	protein kinase A catalytic subunit beta	p73	5567	7161	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of protein_kinase_A_catalytic_subunit_beta as a novel binding partner of p73 and regulation of p73 function .
12458207	0	protein_kinase_B	49,65	AKT	66,69	protein kinase B	AKT	2185	207	Gene	Gene	regulation|nmod|START_ENTITY regulation|parataxis|leads leads|nsubj|END_ENTITY	Negative regulation of mixed_lineage_kinase_3 by protein_kinase_B / AKT leads to cell survival .
26450699	0	protein_kinase_B	129,145	AKT1	147,151	protein kinase B	AKT1	2185	207	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	MicroRNA-derived network analysis of differentially methylated genes in schizophrenia , implicating GABA_receptor_B1 -LSB- GABBR1 -RSB- and protein_kinase_B -LSB- AKT1 -RSB- .
10467260	0	protein_kinase_B	23,39	Akt	18,21	protein kinase B	Akt	2185	207	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of Akt -LRB- protein_kinase_B -RRB- confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli .
11313479	0	protein_kinase_B	32,48	Akt	50,53	protein kinase B	Akt	2185	207	Gene	Gene	import|nmod|START_ENTITY Inhibition|nmod|import Inhibition|appos|END_ENTITY	Inhibition of nuclear import by protein_kinase_B -LRB- Akt -RRB- regulates the subcellular distribution and activity of the forkhead transcription factor AFX .
11574400	0	protein_kinase_B	109,125	Akt	126,129	protein kinase B	Akt	2185	207	Gene	Gene	inhibition|nmod|START_ENTITY not|nmod|inhibition activity|dep|not END_ENTITY|nsubj|activity	A role for protein phosphatase 2A-like activity , but not atypical protein kinase Czeta , in the inhibition of protein_kinase_B / Akt and glycogen synthesis by palmitate .
11694510	0	protein_kinase_B	71,87	Akt	88,91	protein kinase B	Akt	2185	207	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Inhibition of cAMP-response_element-binding_protein activity decreases protein_kinase_B / Akt expression in 3T3-L1 adipocytes and induces apoptosis .
12082147	0	protein_kinase_B	36,52	Akt	53,56	protein kinase B	Akt	2185	207	Gene	Gene	targeting|dobj|START_ENTITY consequence|acl|targeting consequence|parataxis|vesicles vesicles|nsubj|END_ENTITY	Functional consequence of targeting protein_kinase_B / Akt to GLUT4 vesicles .
12086620	0	protein_kinase_B	42,58	Akt	59,62	protein kinase B	Akt	2185	207	Gene	Gene	regulation|nmod|START_ENTITY mechanism|nmod|regulation mechanism|dep|END_ENTITY	Molecular mechanism for the regulation of protein_kinase_B / Akt by hydrophobic motif phosphorylation .
12479697	0	protein_kinase_B	27,43	Akt	44,47	protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|parataxis|apoptosis apoptosis|nsubj|END_ENTITY	Indole-3-carbinol inhibits protein_kinase_B / Akt and induces apoptosis in the human breast_tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line .
14611643	0	protein_kinase_B	87,103	Akt	105,108	protein kinase B	Akt	2185	207	Gene	Gene	PKB|appos|START_ENTITY PKB|dep|substrate substrate|dep|END_ENTITY	WNK1 , the kinase mutated in an inherited_high-blood-pressure_syndrome , is a novel PKB -LRB- protein_kinase_B -RRB- / Akt substrate .
15367694	0	protein_kinase_B	101,117	Akt	96,99	protein kinase B	Akt	2185	207	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Protein phosphatase 2A negatively regulates insulin 's metabolic signaling pathway by inhibiting Akt -LRB- protein_kinase_B -RRB- activity in 3T3-L1 adipocytes .
15583002	0	protein_kinase_B	28,44	Akt	45,48	protein kinase B	Akt	2185	207	Gene	Gene	dynamics|nmod|START_ENTITY dynamics|parataxis|revealed revealed|nsubj|signaling signaling|compound|END_ENTITY	Spatio-temporal dynamics of protein_kinase_B / Akt signaling revealed by a genetically encoded fluorescent reporter .
16397254	0	protein_kinase_B	97,113	Akt	114,117	protein kinase B	Akt	2185	207	Gene	Gene	dependence|nmod|START_ENTITY dependence|dep|activation activation|compound|END_ENTITY	Preferential dependence of breast_cancer cells versus normal cells on integrin-linked_kinase for protein_kinase_B / Akt activation and cell survival .
16619501	0	protein_kinase_B	48,64	Akt	65,68	protein kinase B	Akt	2185	207	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Tumour suppressor PTEN regulates cell cycle and protein_kinase_B / Akt pathway in breast_cancer cells .
17567589	0	protein_kinase_B	54,70	Akt	71,74	protein kinase B	Akt	2185	207	Gene	Gene	START_ENTITY|dep|involvement involvement|compound|END_ENTITY	p53 response to arsenic exposure in epithelial cells : protein_kinase_B / Akt involvement .
18250332	0	protein_kinase_B	61,77	Akt	78,81	protein kinase B	Akt	2185	207	Gene	Gene	receptors|nmod|START_ENTITY Phosphorylation|dep|receptors Phosphorylation|parataxis|inhibits inhibits|nsubj|END_ENTITY	Phosphorylation of inositol_1 ,4,5 - trisphosphate receptors by protein_kinase_B / Akt inhibits Ca2 + release and apoptosis .
19703999	0	protein_kinase_B	97,113	Akt	114,117	protein kinase B	Akt	2185	207	Gene	Gene	regulates|dobj|START_ENTITY kinase|acl:relcl|regulates binding|nmod|kinase signaling|amod|binding signaling|compound|END_ENTITY	Phosphoinositide -LRB- 3,4,5 -RRB- - triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein_kinase_B / Akt signaling threshold that dictates T-cell migration , not proliferation .
21380726	0	protein_kinase_B	20,36	Akt	37,40	protein kinase B	Akt	2185	207	Gene	Gene	effect|nmod|START_ENTITY effect|parataxis|signal-regulated signal-regulated|nsubj|END_ENTITY	Different effect of protein_kinase_B / Akt and extracellular signal-regulated kinase inhibition on trichostatin_A-induced apoptosis in epithelial_ovarian_carcinoma cell lines .
22280833	0	protein_kinase_B	14,30	Akt	31,34	protein kinase B	Akt	2185	207	Gene	Gene	Activation|nmod|START_ENTITY Activation|dep|END_ENTITY	Activation of protein_kinase_B / Akt by alpha1-adrenoceptors in the human prostate .
10385529	0	protein_kinase_B	16,32	B_cell_antigen_receptor	51,74	protein kinase B	B cell antigen receptor	2185	613	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	The dynamics of protein_kinase_B regulation during B_cell_antigen_receptor engagement .
10567225	0	protein_kinase_B	53,69	Mammalian_target_of_rapamycin	0,29	protein kinase B	Mammalian target of rapamycin	2185	2475	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Mammalian_target_of_rapamycin is a direct target for protein_kinase_B : identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation .
11781306	0	protein_kinase_B	67,83	PKB	85,88	protein kinase B	PKB	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Phosphatidylinositol -LRB- 3,4,5 -RRB- P3 is essential but not sufficient for protein_kinase_B -LRB- PKB -RRB- activation ; phosphatidylinositol -LRB- 3,4 -RRB- P2 is required for PKB phosphorylation at Ser-473 : studies using cells from SH2-containing_inositol-5-phosphatase knockout mice .
16902245	0	protein_kinase_B	47,63	PKB/AKT	65,72	protein kinase B	PKB/AKT	2185	207	Gene	Gene	inhibitors|nmod|START_ENTITY Identification|nmod|inhibitors Identification|appos|END_ENTITY	Identification of small-molecule inhibitors of protein_kinase_B -LRB- PKB/AKT -RRB- in an AlphaScreenTM high-throughput screen .
16842970	0	protein_kinase_B	14,30	PTEN	43,47	protein kinase B	PTEN	2185	5728	Gene	Gene	activity|amod|START_ENTITY Regulation|nmod|activity Regulation|nmod|END_ENTITY	Regulation of protein_kinase_B activity by PTEN and SHIP2 in human prostate-derived cell lines .
20687898	0	protein_kinase_B	67,83	insulin	45,52	protein kinase B	insulin	2185	3630	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|activation activation|nmod|END_ENTITY	Heart 6-phosphofructo-2-kinase activation by insulin requires PKB -LRB- protein_kinase_B -RRB- , but not SGK3 -LRB- serum - _ and_glucocorticoid-induced_protein_kinase_3 -RRB- .
15036397	0	protein_kinase_B	44,60	mammalian_target_of_rapamycin	67,96	protein kinase B	mammalian target of rapamycin	2185	2475	Gene	Gene	Effects|nmod|START_ENTITY Effects|parataxis|signaling signaling|nsubj|END_ENTITY	Effects of aerobic exercise training on the protein_kinase_B -LRB- PKB -RRB- / mammalian_target_of_rapamycin -LRB- mTOR -RRB- signaling pathway in aged skeletal muscle .
22657251	0	protein_kinase_B	5,21	mammalian_target_of_rapamycin	81,110	protein kinase B	mammalian target of rapamycin	2185	2475	Gene	Gene	Akt|appos|START_ENTITY isoform|nsubj|Akt isoform|dobj|downstream downstream|nmod|mTOR mTOR|appos|END_ENTITY	Akt -LRB- protein_kinase_B -RRB- isoform phosphorylation and signaling downstream of mTOR -LRB- mammalian_target_of_rapamycin -RRB- in denervated atrophic and hypertrophic mouse skeletal muscle .
23920219	0	protein_kinase_B	134,150	mammalian_target_of_rapamycin	153,182	protein kinase B	mammalian target of rapamycin	2185	2475	Gene	Gene	Akt|appos|START_ENTITY 3-kinase|appos|Akt 3-kinase|acl|END_ENTITY	Insights into insulin-mediated regulation of CYP2E1 : miR-132 / -212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase , Akt -LRB- protein_kinase_B -RRB- , mammalian_target_of_rapamycin signaling in regulating miR-132 / -212 and miR-122 / -181 a expression in primary cultured rat hepatocytes .
9636226	0	protein_kinase_B	113,129	mammalian_target_of_rapamycin	69,98	protein kinase B	mammalian target of rapamycin	2185	2475	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|Evidence Evidence|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Evidence of insulin-stimulated phosphorylation and activation of the mammalian_target_of_rapamycin mediated by a protein_kinase_B signaling pathway .
12458207	0	protein_kinase_B	49,65	mixed_lineage_kinase_3	23,45	protein kinase B	mixed lineage kinase 3	2185	4296	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of mixed_lineage_kinase_3 by protein_kinase_B / AKT leads to cell survival .
18828666	0	protein_kinase_B	63,79	phosphatidylinositol_3-kinase	24,53	protein kinase B	phosphatidylinositol 3-kinase	399170(Tax:8355)	373752(Tax:8355)	Gene	Gene	START_ENTITY|nsubj|involvement involvement|nmod|END_ENTITY	Possible involvement of phosphatidylinositol_3-kinase , but not protein_kinase_B or glycogen_synthase_kinase_3beta , in progesterone-induced oocyte maturation in the Japanese brown frog , Rana japonica .
20153226	0	protein_kinase_B-alpha	47,69	Akt1	71,75	protein kinase B-alpha	Akt1	207	207	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	A comprehensive structure-activity analysis of protein_kinase_B-alpha -LRB- Akt1 -RRB- inhibitors .
11997518	0	protein_kinase_B_alpha	24,46	AKT-1	18,23	protein kinase B alpha	AKT-1	11651(Tax:10090)	11651(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Essential role of AKT-1 / protein_kinase_B_alpha in PTEN-controlled tumorigenesis .
9857186	0	protein_kinase_Balpha	38,59	PKBalpha	61,69	protein kinase Balpha	PKBalpha	207	207	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|appos|END_ENTITY	Inactivation and dephosphorylation of protein_kinase_Balpha -LRB- PKBalpha -RRB- promoted by hyperosmotic stress .
10523666	0	protein_kinase_Bbeta	11,31	Akt2	32,36	protein kinase Bbeta	Akt2	25233(Tax:10116)	25233(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for protein_kinase_Bbeta / Akt2 in insulin-stimulated GLUT4 translocation in adipocytes .
12733988	0	protein_kinase_C	328,344	CPI-17	345,351	protein kinase C	CPI-17	112476	94274	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Differential signalling by muscarinic receptors in smooth muscle : m2-mediated inactivation of myosin_light_chain_kinase via Gi3 , Cdc42/Rac1 and p21-activated_kinase_1 pathway , and m3-mediated MLC20 -LRB- 20_kDa_regulatory_light_chain_of_myosin_II -RRB- phosphorylation via Rho-associated kinase/myosin _ phosphatase_targeting_subunit 1 and protein_kinase_C / CPI-17 pathway .
11560479	0	protein_kinase_C	54,70	CYP3A4	44,50	protein kinase C	CYP3A4	112476	1576	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of native and heme-modified CYP3A4 by protein_kinase_C : a mass spectrometric characterization of the phosphorylated peptides .
7613626	0	protein_kinase_C	11,27	GAP-43	63,69	protein kinase C	GAP-43	24681(Tax:10116)	29423(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY END_ENTITY|dep|Changes	Changes in protein_kinase_C and its presynaptic substrate B-50 / GAP-43 after intrauterine exposure to methylazoxy-methanol , a treatment inducing cortical and hippocampal_damage and cognitive_deficit in rats .
1850304	0	protein_kinase_C	12,28	Mac-1	122,127	protein kinase C	Mac-1	112476	3684	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	The role of protein_kinase_C activation and inositol_phosphate production in the regulation of cell-surface expression of Mac-1 by complement fragment C5a .
12757721	1	protein_kinase_C	74,90	PK-C	92,96	protein kinase C	PK-C	112476	112476	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect on protein_kinase_C -LRB- PK-C -RRB- binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones .
24825907	0	protein_kinase_C	40,56	PKC	60,63	protein kinase C	PKC	112476	112476	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of oncogenic protein_kinase_C -LRB- PKC -RRB- by STAT1 and Sp1 proteins .
8562306	0	protein_kinase_C	16,32	PKC	34,37	protein kinase C	PKC	24681(Tax:10116)	24681(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	The heat-stable protein_kinase_C -LRB- PKC -RRB- stimulatory factor in the rat ovary may allow PKC to be active independent of cell membrane lipids .
24825907	0	protein_kinase_C	40,56	STAT1	70,75	protein kinase C	STAT1	112476	6772	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|proteins proteins|compound|END_ENTITY	Transcriptional regulation of oncogenic protein_kinase_C -LRB- PKC -RRB- by STAT1 and Sp1 proteins .
1310621	0	protein_kinase_C	14,30	annexin_V	34,43	protein kinase C	annexin V	112476	308	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of protein_kinase_C by annexin_V .
2474543	0	protein_kinase_C	13,29	interferon-alpha_A	90,108	protein kinase C	interferon-alpha A	112476	3440	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	A functional protein_kinase_C is required for induction of 2-5A synthetase by recombinant interferon-alpha_A in Daudi cells .
3130982	0	protein_kinase_C	8,24	vinculin	47,55	protein kinase C	vinculin	112476	7414	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of protein_kinase_C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells .
21756056	0	protein_kinase_C-Eta	40,60	PRKCH	62,67	protein kinase C-Eta	PRKCH	5583	5583	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Contribution of 1425G/A polymorphism in protein_kinase_C-Eta -LRB- PRKCH -RRB- gene and brain white_matter_lesions to the risk of sudden_sensorineural_hearing_loss in a Japanese nested case-control study .
12623995	0	protein_kinase_C-alpha	89,111	Akt	16,19	protein kinase C-alpha	Akt	5578	207	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|activation activation|compound|END_ENTITY	Insulin-induced Akt activation is inhibited by angiotensin_II in the vasculature through protein_kinase_C-alpha .
19699794	0	protein_kinase_C-alpha	24,46	ERK1/2	14,20	protein kinase C-alpha	ERK1/2	5578	5595;5594	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of ERK1/2 by protein_kinase_C-alpha in response to hydrogen_peroxide-induced cell death in human gingival fibroblasts .
11290387	0	protein_kinase_C-alpha	94,116	PKC-alpha	118,127	protein kinase C-alpha	PKC-alpha	5578	5578	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Effects of apolipoprotein_E _ -LRB- apoE -RRB- _ isoforms , _ beta-amyloid _ -LRB- Abeta -RRB- and apoE/Abeta complexes on protein_kinase_C-alpha -LRB- PKC-alpha -RRB- translocation and amyloid_precursor_protein -LRB- APP -RRB- processing in human SH-SY5Y neuroblastoma cells and fibroblasts .
14687784	0	protein_kinase_C-alpha	12,34	PKC-alpha	36,45	protein kinase C-alpha	PKC-alpha	5578	5578	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of protein_kinase_C-alpha -LRB- PKC-alpha -RRB- in malignancies of the gastrointestinal tract .
15057036	0	protein_kinase_C-alpha	12,34	PKC-alpha	36,45	protein kinase C-alpha	PKC-alpha	5578	5578	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of protein_kinase_C-alpha -LRB- PKC-alpha -RRB- in melanoma .
15180529	0	protein_kinase_C-alpha	12,34	PKC-alpha	36,45	protein kinase C-alpha	PKC-alpha	5578	5578	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of protein_kinase_C-alpha -LRB- PKC-alpha -RRB- in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen .
14670076	0	protein_kinase_C-alpha	61,83	Syndecan-4	0,10	protein kinase C-alpha	Syndecan-4	5578	6385	Gene	Gene	localization|nmod|START_ENTITY regulates|dobj|localization regulates|nsubj|END_ENTITY	Syndecan-4 regulates localization , activity and stability of protein_kinase_C-alpha .
12939231	0	protein_kinase_C-alpha	108,130	TGF-beta1	16,25	protein kinase C-alpha	TGF-beta1	18750(Tax:10090)	21803(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|END_ENTITY	Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein_kinase_C-alpha .
17942932	0	protein_kinase_C-alpha	61,83	epidermal_growth_factor_receptor	15,47	protein kinase C-alpha	epidermal growth factor receptor	5578	1956	Gene	Gene	activation|amod|START_ENTITY signaling|nmod|activation END_ENTITY|acl|signaling	Suppression of epidermal_growth_factor_receptor signaling by protein_kinase_C-alpha activation requires CD82 , caveolin-1 , and ganglioside .
8978751	0	protein_kinase_C-alpha	14,36	myristoylated_alanine-rich_C-kinase_substrate	62,107	protein kinase C-alpha	myristoylated alanine-rich C-kinase substrate	5578	4082	Gene	Gene	START_ENTITY|nmod|correlate correlate|amod|END_ENTITY	Activation of protein_kinase_C-alpha and translocation of the myristoylated_alanine-rich_C-kinase_substrate correlate with phorbol_ester-enhanced noradrenaline release from SH-SY5Y human neuroblastoma cells .
17313671	0	protein_kinase_C-beta	26,47	PKC-beta	49,57	protein kinase C-beta	PKC-beta	5579	5579	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Retrospective analysis of protein_kinase_C-beta -LRB- PKC-beta -RRB- expression in lymphoid_malignancies and its association with survival in diffuse large B-cell_lymphomas .
16567829	0	protein_kinase_C-beta	21,42	PRKCB1	49,55	protein kinase C-beta	PRKCB1	5579	5579	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the protein_kinase_C-beta gene -LRB- PRKCB1 -RRB- accelerate kidney disease in type 2 diabetes without overt proteinuria .
9139733	0	protein_kinase_C-delta	82,104	GAP-43	52,58	protein kinase C-delta	GAP-43	5580	2596	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Regulated binding of the protein kinase C substrate GAP-43 to the V0/C2 region of protein_kinase_C-delta .
15850832	0	protein_kinase_C-delta	8,30	PKC-delta	32,41	protein kinase C-delta	PKC-delta	5580	5580	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of protein_kinase_C-delta -LRB- PKC-delta -RRB- in the generation of the effects of IFN-alpha in chronic_myelogenous_leukemia cells .
17407153	0	protein_kinase_C-delta	93,115	PKC-delta	117,126	protein kinase C-delta	PKC-delta	5580	5580	Gene	Gene	signal|amod|START_ENTITY signal|appos|END_ENTITY	Expression of cyclin_D3 through Sp1 sites by histone deacetylase inhibitors is mediated with protein_kinase_C-delta -LRB- PKC-delta -RRB- signal pathway .
9692543	0	protein_kinase_C-delta	190,212	Src	160,163	protein kinase C-delta	Src	170538(Tax:10116)	83805(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	protein_kinase_C-delta	190,212	Src	96,99	protein kinase C-delta	Src	170538(Tax:10116)	83805(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY regulation|nmod|activity phosphorylation-dependent|dep|regulation phosphorylation-dependent|dep|associations associations|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	protein_kinase_C-delta	68,90	Src	160,163	protein kinase C-delta	Src	170538(Tax:10116)	83805(Tax:10116)	Gene	Gene	associations|nmod|START_ENTITY phosphorylation-dependent|dep|associations phosphorylation-dependent|dep|regulation regulation|nmod|activity activity|compound|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	protein_kinase_C-delta	68,90	Src	96,99	protein kinase C-delta	Src	170538(Tax:10116)	83805(Tax:10116)	Gene	Gene	associations|nmod|START_ENTITY associations|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
12151312	0	protein_kinase_C-delta	62,84	cyclin_D1	35,44	protein kinase C-delta	cyclin D1	505708(Tax:9913)	524530(Tax:9913)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of airway smooth muscle cyclin_D1 transcription by protein_kinase_C-delta .
19169273	0	protein_kinase_C-delta	81,103	cyclooxygenase-2	34,50	protein kinase C-delta	cyclooxygenase-2	5580	5743	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|induction induction|amod|END_ENTITY	Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein_kinase_C-delta .
9692543	0	protein_kinase_C-delta	190,212	protein_kinase_C-delta	68,90	protein kinase C-delta	protein kinase C-delta	170538(Tax:10116)	170538(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY regulation|nmod|activity phosphorylation-dependent|dep|regulation phosphorylation-dependent|dep|associations associations|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
9692543	0	protein_kinase_C-delta	68,90	protein_kinase_C-delta	190,212	protein kinase C-delta	protein kinase C-delta	170538(Tax:10116)	170538(Tax:10116)	Gene	Gene	associations|nmod|START_ENTITY phosphorylation-dependent|dep|associations phosphorylation-dependent|dep|regulation regulation|nmod|activity activity|nmod|END_ENTITY	Tyrosine phosphorylation-dependent and - independent associations of protein_kinase_C-delta with Src family kinases in the RBL-2H3 mast cell line : regulation of Src family kinase activity by protein_kinase_C-delta .
12036603	0	protein_kinase_C-epsilon	74,98	B_cell_antigen_receptor	106,129	protein kinase C-epsilon	B cell antigen receptor	5581	613	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Activation and phosphatidylinositol 3-kinase-dependent phosphorylation of protein_kinase_C-epsilon by the B_cell_antigen_receptor .
15542537	0	protein_kinase_C-epsilon	8,32	PKCepsilon	34,44	protein kinase C-epsilon	PKCepsilon	29340(Tax:10116)	29340(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of protein_kinase_C-epsilon -LRB- PKCepsilon -RRB- in isoflurane-induced cardioprotection .
11356906	0	protein_kinase_C-epsilon	15,39	thrombopoietin	66,80	protein kinase C-epsilon	thrombopoietin	18754(Tax:10090)	21832(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of protein_kinase_C-epsilon in signal transduction of thrombopoietin in enhancement of interleukin-3-dependent proliferation of primitive hematopoietic progenitors .
10818102	0	protein_kinase_C-related_kinase_2	33,66	MEK_kinase_2	0,12	protein kinase C-related kinase 2	MEK kinase 2	5586	10746	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	MEK_kinase_2 binds and activates protein_kinase_C-related_kinase_2 .
10716728	0	protein_kinase_C-theta	83,105	NF-kappa_B	0,10	protein kinase C-theta	NF-kappa B	5588	4790	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|activation activation|amod|END_ENTITY	NF-kappa_B activation induced by T cell receptor/CD28 costimulation is mediated by protein_kinase_C-theta .
21645497	0	protein_kinase_C-zeta	38,59	PKC	61,64	protein kinase C-zeta	PKC	5590	5590	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|appos|END_ENTITY	Differential dephosphorylation of the protein_kinase_C-zeta -LRB- PKC -RRB- in an integrin aIIbb3-dependent manner in platelets .
8797581	0	protein_kinase_C-zeta	18,39	PKC-zeta	41,49	protein kinase C-zeta	PKC-zeta	25522(Tax:10116)	25522(Tax:10116)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of protein_kinase_C-zeta -LRB- PKC-zeta -RRB- inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells .
12952980	0	protein_kinase_C_alpha	29,51	Apolipoprotein_A-I	0,18	protein kinase C alpha	Apolipoprotein A-I	5578	335	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Apolipoprotein_A-I activates protein_kinase_C_alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly .
17324928	0	protein_kinase_C_alpha	87,109	Munc18c	129,136	protein kinase C alpha	Munc18c	5578	6814	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Alcohol/cholecystokinin-evoked pancreatic acinar basolateral exocytosis is mediated by protein_kinase_C_alpha phosphorylation of Munc18c .
15755906	0	protein_kinase_C_alpha	151,173	Neurotensin	0,11	protein kinase C alpha	Neurotensin	5578	4922	Gene	Gene	involvement|nmod|START_ENTITY stimulates|parataxis|involvement stimulates|nsubj|END_ENTITY	Neurotensin stimulates interleukin-8 expression through modulation of I_kappa_B_alpha phosphorylation and p65 transcriptional activity : involvement of protein_kinase_C_alpha .
16740968	0	protein_kinase_C_alpha	15,37	PKC_alpha	171,180	protein kinase C alpha	PKC alpha	18750(Tax:10090)	18750(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of protein_kinase_C_alpha -LRB- PKC_alpha -RRB- in the early action of angiotensin II type 2 -LRB- AT2 -RRB- effects on neurite outgrowth in NG108-15 cells : AT2-receptor inhibits PKC_alpha and p21ras activity .
15155525	0	protein_kinase_C_alpha	15,37	PRKCA	39,44	protein kinase C alpha	PRKCA	5578	5578	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of protein_kinase_C_alpha -LRB- PRKCA -RRB- gene with multiple_sclerosis in a UK population .
18401527	0	protein_kinase_C_alpha	89,111	Smac	156,160	protein kinase C alpha	Smac	5578	56616	Gene	Gene	activation|dep|START_ENTITY activation|nmod|END_ENTITY	Inhibition of fibroblast_growth_factor_2-induced apoptosis involves survivin expression , protein_kinase_C_alpha activation and subcellular translocation of Smac in human small_cell_lung_cancer cells .
9486481	0	protein_kinase_C_alpha	18,40	amyloid_precursor_protein	88,113	protein kinase C alpha	amyloid precursor protein	5578	351	Gene	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|nmod|END_ENTITY	Specific role for protein_kinase_C_alpha in the constitutive and regulated secretion of amyloid_precursor_protein in human skin fibroblasts .
9593858	0	protein_kinase_C_alpha	8,30	endothelin-1	34,46	protein kinase C alpha	endothelin-1	5578	1906	Gene	Gene	START_ENTITY|nmod|stimulation stimulation|amod|END_ENTITY	Role of protein_kinase_C_alpha in endothelin-1 stimulation of cytosolic_phospholipase_A2 and arachidonic_acid release in cultured cat iris sphincter smooth muscle cells .
14751567	0	protein_kinase_C_alpha	44,66	estrogen_receptor_alpha	15,38	protein kinase C alpha	estrogen receptor alpha	5578	2099	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of estrogen_receptor_alpha with protein_kinase_C_alpha and c-Src in osteoblasts during differentiation .
20382690	0	protein_kinase_C_alpha	61,83	oxytocin	47,55	protein kinase C alpha	oxytocin	5578	5020	Gene	Gene	manner|compound|START_ENTITY END_ENTITY|nmod|manner	Melatonin sensitizes human myometrial cells to oxytocin in a protein_kinase_C_alpha / extracellular-signal regulated kinase-dependent manner .
9571186	0	protein_kinase_C_alpha	33,55	p53	18,21	protein kinase C alpha	p53	18750(Tax:10090)	22060(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Regulation of the p53 protein by protein_kinase_C_alpha and protein kinase C zeta .
7790386	0	protein_kinase_C_alpha	8,30	transforming_growth_factor_beta_1	79,112	protein kinase C alpha	transforming growth factor beta 1	5578	7040	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of protein_kinase_C_alpha in the induction of carcinoembryonic_antigen by transforming_growth_factor_beta_1 .
9856494	0	protein_kinase_C_beta	63,84	PRKCB	91,96	protein kinase C beta	PRKCB	5579	5579	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Elucidation of the exon-intron structure and size of the human protein_kinase_C_beta gene -LRB- PRKCB -RRB- .
1809396	0	protein_kinase_C_beta_1	97,120	Endothelin-1	0,12	protein kinase C beta 1	Endothelin-1	25023(Tax:10116)	24323(Tax:10116)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Endothelin-1 activates phospholipase_D and thymidine incorporation in fibroblasts overexpressing protein_kinase_C_beta_1 .
19995395	0	protein_kinase_C_delta	13,35	NOTCH2	0,6	protein kinase C delta	NOTCH2	5580	4853	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	NOTCH2 links protein_kinase_C_delta to the expression of CD23 in chronic_lymphocytic_leukaemia -LRB- CLL -RRB- cells .
17959229	0	protein_kinase_C_delta	12,34	PKC_delta	36,45	protein kinase C delta	PKC delta	5580	5580	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Analysis of protein_kinase_C_delta -LRB- PKC_delta -RRB- expression in endometrial_tumors .
10713064	0	protein_kinase_C_delta	15,37	PKCdelta	39,47	protein kinase C delta	PKCdelta	5580	5580	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of protein_kinase_C_delta -LRB- PKCdelta -RRB- in phorbol_ester-induced apoptosis in LNCaP_prostate_cancer cells .
25116760	0	protein_kinase_C_delta	20,42	PRKCD	44,49	protein kinase C delta	PRKCD	505708(Tax:9913)	505708(Tax:9913)	Gene	Gene	requirement|nmod|START_ENTITY requirement|appos|END_ENTITY	The requirement for protein_kinase_C_delta -LRB- PRKCD -RRB- during preimplantation bovine embryo development .
8188219	0	protein_kinase_C_delta	18,40	PRKCD	59,64	protein kinase C delta	PRKCD	5580	5580	Gene	Gene	gene|compound|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of the protein_kinase_C_delta polypeptide gene -LRB- PRKCD -RRB- to human chromosome 3 and mouse chromosome 14 .
11812791	0	protein_kinase_C_delta	33,55	Src	0,3	protein kinase C delta	Src	18753(Tax:10090)	20779(Tax:10090)	Gene	Gene	phosphorylate|dobj|START_ENTITY END_ENTITY|ccomp|phosphorylate	Src family kinases phosphorylate protein_kinase_C_delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes .
20196639	0	protein_kinase_C_delta	9,31	UGT1A6	68,74	protein kinase C delta	UGT1A6	5580	54578	Gene	Gene	START_ENTITY|nmod|activity activity|nmod|END_ENTITY	Role for protein_kinase_C_delta in the functional activity of human UGT1A6 : implications for drug-drug interactions between PKC inhibitors and UGT1A6 .
9153199	0	protein_kinase_C_delta	27,49	gonadotropin-releasing_hormone	81,111	protein kinase C delta	gonadotropin-releasing hormone	5580	2796	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	Differential activation of protein_kinase_C_delta and epsilon gene expression by gonadotropin-releasing_hormone in alphaT3-1 cells .
19458088	0	protein_kinase_C_delta	24,46	protein_kinase_D1	79,96	protein kinase C delta	protein kinase D1	5580	5587	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|nmod|END_ENTITY	Sprouty2 interacts with protein_kinase_C_delta and disrupts phosphorylation of protein_kinase_D1 .
7516899	0	protein_kinase_C_delta	44,66	src	90,93	protein kinase C delta	src	5580	6714	Gene	Gene	phosphorylation|nmod|START_ENTITY Tyrosine|dobj|phosphorylation Tyrosine|nmod|END_ENTITY	Tyrosine phosphorylation and stimulation of protein_kinase_C_delta from porcine spleen by src in vitro .
17508994	0	protein_kinase_C_gamma	10,32	PRKCG	39,44	protein kinase C gamma	PRKCG	5582	5582	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human protein_kinase_C_gamma gene -LRB- PRKCG -RRB- as a susceptibility locus for behavioral_disinhibition .
24925028	0	protein_kinase_Ca	22,39	MicroRNA-200b	0,13	protein kinase Ca	MicroRNA-200b	5578	406984	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-200b targets protein_kinase_Ca and suppresses triple-negative breast_cancer metastasis .
26323260	0	protein_kinase_Ca	102,119	PKCa	121,125	protein kinase Ca	PKCa	5578	5578	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Reversal of efflux of an anticancer drug in human drug-resistant breast cancer cells by inhibition of protein_kinase_Ca -LRB- PKCa -RRB- activity .
26323260	0	protein_kinase_Ca	102,119	PKCa	121,125	protein kinase Ca	PKCa	5578	5578	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Reversal of efflux of an anticancer drug in human drug-resistant breast cancer cells by inhibition of protein_kinase_Ca -LRB- PKCa -RRB- activity .
18458086	0	protein_kinase_Cepsilon	34,57	MyD88	13,18	protein kinase Cepsilon	MyD88	18754(Tax:10090)	17874(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The scaffold MyD88 acts to couple protein_kinase_Cepsilon to Toll-like receptors .
10438519	0	protein_kinase_Cepsilon	15,38	PKCepsilon	40,50	protein kinase Cepsilon	PKCepsilon	5581	5581	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of protein_kinase_Cepsilon -LRB- PKCepsilon -RRB- in thyroid cell death .
11839754	0	protein_kinase_Cepsilon	39,62	PKCepsilon	209,219	protein kinase Cepsilon	PKCepsilon	100009103(Tax:9986)	100009103(Tax:9986)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Nitric_oxide -LRB- NO -RRB- induces nitration of protein_kinase_Cepsilon -LRB- PKCepsilon -RRB- , facilitating PKCepsilon translocation via enhanced PKCepsilon - RACK2 interactions : a novel mechanism of no-triggered activation of PKCepsilon .
15467523	0	protein_kinase_Cgamma	80,101	connexin46	32,42	protein kinase Cgamma	connexin46	5582	2700	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Differential phosphorylation of connexin46 and connexin50 by H2O2 activation of protein_kinase_Cgamma .
14670960	0	protein_kinase_Ciota	18,38	Bcr-Abl	0,7	protein kinase Ciota	Bcr-Abl	5584	25	Gene	Gene	transcription|amod|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	Bcr-Abl regulates protein_kinase_Ciota -LRB- PKCiota -RRB- transcription via an Elk1 site in the PKCiota promoter .
18050214	0	protein_kinase_Czeta	15,35	ADAMTS-4	70,78	protein kinase Czeta	ADAMTS-4	5590	9507	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|END_ENTITY	Involvement of protein_kinase_Czeta in interleukin-1beta induction of ADAMTS-4 and type 2 nitric_oxide synthase via NF-kappaB signaling in primary human osteoarthritic chondrocytes .
18397319	0	protein_kinase_Czeta	82,102	AKAP12	0,6	protein kinase Czeta	AKAP12	5590	9590	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	AKAP12 in astrocytes induces barrier functions in human endothelial cells through protein_kinase_Czeta .
18568943	0	protein_kinase_Czeta	81,101	Sp1	58,61	protein kinase Czeta	Sp1	5590	6667	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein_kinase_Czeta modulates membrane_type_1-matrix_metalloproteinase in endothelial cells .
21189263	0	protein_kinase_D	15,31	ATP7B	65,70	protein kinase D	ATP7B	5587	540	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of protein_kinase_D in expression and trafficking of ATP7B -LRB- copper ATPase -RRB- .
11903052	0	protein_kinase_D	15,31	Fc_gamma-receptor	35,52	protein kinase D	Fc gamma-receptor	5587	2209	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Involvement of protein_kinase_D in Fc_gamma-receptor activation of the NADPH oxidase in neutrophils .
11912133	0	protein_kinase_D	47,63	Neurotensin	0,11	protein kinase D	Neurotensin	5587	4922	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Neurotensin induces protein_kinase_C-dependent protein_kinase_D activation and DNA synthesis in human pancreatic_carcinoma cell line PANC-1 .
12407104	0	protein_kinase_D	32,48	Protein_kinase_C	0,16	protein kinase D	Protein kinase C	5587	112476	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	Protein_kinase_C phosphorylates protein_kinase_D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain .
21209314	0	protein_kinase_D	8,24	Rab_interactor_1	70,86	protein kinase D	Rab interactor 1	5587	9610	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	A novel protein_kinase_D phosphorylation site in the tumor suppressor Rab_interactor_1 is critical for coordination of cell migration .
16772297	0	protein_kinase_D	83,99	RhoA	29,33	protein kinase D	RhoA	18760(Tax:10090)	11848(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY Differential|advcl|localization Differential|dobj|requirement requirement|nmod|GTPase GTPase|compound|END_ENTITY	Differential requirement for RhoA GTPase depending on the cellular localization of protein_kinase_D .
12431976	0	protein_kinase_D	25,41	Thrombin	0,8	protein kinase D	Thrombin	5587	2147	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Thrombin rapidly induces protein_kinase_D phosphorylation , and protein_kinase_C_delta mediates the activation .
17494074	0	protein_kinase_D	95,111	X-box-binding_protein_1	0,23	protein kinase D	X-box-binding protein 1	5587	7494	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	X-box-binding_protein_1 activates lytic Epstein-Barr_virus gene expression in combination with protein_kinase_D .
15123666	0	protein_kinase_D	12,28	neurotensin	32,43	protein kinase D	neurotensin	5587	4922	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	The role of protein_kinase_D in neurotensin secretion mediated by protein_kinase_C-alpha / - delta_and_Rho / Rho kinase .
23178798	0	protein_kinase_D	53,69	phospholipase_D	11,26	protein kinase D	phospholipase D	5587	2822	Gene	Gene	activation|amod|START_ENTITY role|nmod|activation role|nmod|END_ENTITY	A role for phospholipase_D in angiotensin_II-induced protein_kinase_D activation in adrenal glomerulosa cell models .
26443497	0	protein_kinase_D1	55,72	Heat_shock_protein_20	0,21	protein kinase D1	Heat shock protein 20	5587	126393	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Heat_shock_protein_20 -LRB- HSP20 -RRB- is a novel substrate for protein_kinase_D1 -LRB- PKD1 -RRB- .
19767773	0	protein_kinase_D1	75,92	Heat_shock_protein_27	0,21	protein kinase D1	Heat shock protein 27	5587	3315	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Heat_shock_protein_27 mediates repression of androgen_receptor function by protein_kinase_D1 in prostate_cancer cells .
19173301	0	protein_kinase_D1	77,94	NF-kappaB	35,44	protein kinase D1	NF-kappaB	5587	4790	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein_kinase_D1 .
19458088	0	protein_kinase_D1	79,96	protein_kinase_C_delta	24,46	protein kinase D1	protein kinase C delta	5587	5580	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Sprouty2 interacts with protein_kinase_C_delta and disrupts phosphorylation of protein_kinase_D1 .
24337579	0	protein_kinase_D3	9,26	PKD3	28,32	protein kinase D3	PKD3	23683	23683	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Elevated protein_kinase_D3 -LRB- PKD3 -RRB- expression supports proliferation of triple-negative_breast_cancer cells and contributes to mTORC1-S6K1 pathway activation .
10924361	0	protein_kinase_N	66,82	CPI-17	19,25	protein kinase N	CPI-17	5585	94274	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of CPI-17 , an inhibitor of myosin phosphatase , by protein_kinase_N .
12176338	0	protein_kinase_b	63,79	akt	80,83	protein kinase b	akt	2185	207	Gene	Gene	domain|nmod|START_ENTITY structure|nmod|domain structure|dep|bound bound|advmod|END_ENTITY	High-resolution structure of the pleckstrin homology domain of protein_kinase_b / akt bound to phosphatidylinositol _ -LRB- 3,4,5 -RRB- - trisphosphate .
12185081	0	protein_kinase_cepsilon	55,78	caveolin-1	14,24	protein kinase cepsilon	caveolin-1	5581	857	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of caveolin-1 expression and secretion by a protein_kinase_cepsilon signaling pathway in human prostate_cancer cells .
8224813	0	protein_phosphatase_1	17,38	87B	47,50	protein phosphatase 1	87B	49260(Tax:7227)	49260(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Mutations in the protein_phosphatase_1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila_melanogaster .
16530423	0	protein_phosphatase_1	57,78	DCX	49,52	protein phosphatase 1	DCX	5464	1641	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|appos|END_ENTITY	Site-specific dephosphorylation of doublecortin -LRB- DCX -RRB- by protein_phosphatase_1 -LRB- PP1 -RRB- .
16530423	0	protein_phosphatase_1	57,78	doublecortin	35,47	protein phosphatase 1	doublecortin	5464	1641	Gene	Gene	dephosphorylation|nmod|START_ENTITY dephosphorylation|nmod|END_ENTITY	Site-specific dephosphorylation of doublecortin -LRB- DCX -RRB- by protein_phosphatase_1 -LRB- PP1 -RRB- .
25846879	0	protein_phosphatase_1_regulatory_subunit_3C	61,104	PPP1R3C	106,113	protein phosphatase 1 regulatory subunit 3C	PPP1R3C	5507	5507	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The effect of high glucose levels on the hypermethylation of protein_phosphatase_1_regulatory_subunit_3C -LRB- PPP1R3C -RRB- gene in colorectal_cancer .
9339378	0	protein_phosphatase_1c_gamma	59,87	Ppp1cc	89,95	protein phosphatase 1c gamma	Ppp1cc	19047(Tax:10090)	19047(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and functional analysis of the murine protein_phosphatase_1c_gamma -LRB- Ppp1cc -RRB- gene .
17456047	0	protein_phosphatase_2Cepsilon	54,83	apoptosis_signal-regulating_kinase_1	14,50	protein phosphatase 2Cepsilon	apoptosis signal-regulating kinase 1	151742	4217	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of apoptosis_signal-regulating_kinase_1 by protein_phosphatase_2Cepsilon .
24514563	0	protein_phosphatase_3_catalytic_subunit_alpha_isoform	64,117	PPP3CA	119,125	protein phosphatase 3 catalytic subunit alpha isoform	PPP3CA	102176770	102176770	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , structural analysis and tissue expression of protein_phosphatase_3_catalytic_subunit_alpha_isoform -LRB- PPP3CA -RRB- gene in Tianfu goat muscle .
17965019	0	protein_phosphatase_I	13,34	NOM1	0,4	protein phosphatase I	NOM1	5464	64434	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	NOM1 targets protein_phosphatase_I to the nucleolus .
11278334	0	protein_phosphatase_inhibitor-1	19,50	Cdk5	54,58	protein phosphatase inhibitor-1	Cdk5	5502	1020	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of protein_phosphatase_inhibitor-1 by Cdk5 .
16627590	0	protein_targeting_to_glycogen	24,53	PTG	55,58	protein targeting to glycogen	PTG	53412(Tax:10090)	53412(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the mouse protein_targeting_to_glycogen -LRB- PTG -RRB- promoter by the FoxA2 forkhead protein and by 3 ' ,5 ' - cyclic_adenosine_5 ' - monophosphate in H4IIE hepatoma cells .
9242697	0	protein_targeting_to_glycogen	8,37	PTG	39,42	protein targeting to glycogen	PTG	5507	5507	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of protein_targeting_to_glycogen -LRB- PTG -RRB- in the regulation of protein phosphatase-1 activity .
12707376	0	protein_tyrosine-kinase	13,36	PTK	38,41	protein tyrosine-kinase	PTK	2264	2264	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of protein_tyrosine-kinase -LRB- PTK -RRB- gene expression pattern in normal and malignant T lymphocytes by combined PTK-specific polymerase chain reaction and parallel denaturing gradient gel electrophoresis .
8742077	0	protein_tyrosine_kinase	45,68	c-src	81,86	protein tyrosine kinase	c-src	2046	6714	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	A solid-phase assay for the determination of protein_tyrosine_kinase activity of c-src using scintillating microtitration plates .
7957666	0	protein_tyrosine_kinase	110,133	monocyte_chemoattractant_protein-1	19,53	protein tyrosine kinase	monocyte chemoattractant protein-1	2046	6347	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Gene expression of monocyte_chemoattractant_protein-1 in human monocytes is regulated by cell density through protein_tyrosine_kinase and protein_kinase_C .
18781181	0	protein_tyrosine_kinase_6	20,45	PTK6	47,51	protein tyrosine kinase 6	PTK6	5753	5753	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of protein_tyrosine_kinase_6 -LRB- PTK6 -RRB- for long-term survival of breast_cancer patients .
23525678	0	protein_tyrosine_kinase_6	14,39	PTK6	41,45	protein tyrosine kinase 6	PTK6	5753	5753	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of protein_tyrosine_kinase_6 -LRB- PTK6 -RRB- in nonsmall_cell_lung_cancer and their clinical and prognostic significance .
17997837	0	protein_tyrosine_kinase_6	89,114	Signal_transducer_and_activator_of_transcription_5b	0,51	protein tyrosine kinase 6	Signal transducer and activator of transcription 5b	5753	6777	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Signal_transducer_and_activator_of_transcription_5b : a new target of breast_tumor_kinase / protein_tyrosine_kinase_6 .
12207342	0	protein_tyrosine_phosphatase	18,46	CD45	13,17	protein tyrosine phosphatase	CD45	26191	5788	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Targeting of CD45 protein_tyrosine_phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling .
7533193	0	protein_tyrosine_phosphatase	39,67	CD45	34,38	protein tyrosine phosphatase	CD45	26191	5788	Gene	Gene	activity|compound|START_ENTITY activity|nummod|END_ENTITY	Non-radioactive method to measure CD45 protein_tyrosine_phosphatase activity isolated directly from cells .
23261816	0	protein_tyrosine_phosphatase	48,76	PTPN22	77,83	protein tyrosine phosphatase	PTPN22	26191	26191	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The putative role of the C1858T polymorphism of protein_tyrosine_phosphatase PTPN22 gene in autoimmunity .
16573649	0	protein_tyrosine_phosphatase	4,32	brain-derived_neurotrophic_factor	107,140	protein tyrosine phosphatase	brain-derived neurotrophic factor	26191	627	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	The protein_tyrosine_phosphatase , Shp2 , is required for the complete activation of the RAS/MAPK pathway by brain-derived_neurotrophic_factor .
12920200	0	protein_tyrosine_phosphatase	94,122	cAMP-dependent_protein_kinase	128,157	protein tyrosine phosphatase	cAMP-dependent protein kinase	24697(Tax:10116)	171150(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Adenosine-A2a_receptor down-regulates cerebral smooth muscle L-type Ca2 + channel activity via protein_tyrosine_phosphatase , not cAMP-dependent_protein_kinase .
12612081	0	protein_tyrosine_phosphatase	48,76	insulin_receptor	14,30	protein tyrosine phosphatase	insulin receptor	26191	3643	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of insulin_receptor signaling by the protein_tyrosine_phosphatase TCPTP .
7814416	0	protein_tyrosine_phosphatase	11,39	nerve_growth_factor	51,70	protein tyrosine phosphatase	nerve growth factor	24697(Tax:10116)	310738(Tax:10116)	Gene	Gene	induced|nsubj|START_ENTITY induced|nmod|END_ENTITY	A neuronal protein_tyrosine_phosphatase induced by nerve_growth_factor .
11000134	0	protein_tyrosine_phosphatase	54,82	p38alpha	103,111	protein tyrosine phosphatase	p38alpha	26191	1432	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Adenosine induces endothelial apoptosis by activating protein_tyrosine_phosphatase : a possible role of p38alpha .
20123020	0	protein_tyrosine_phosphatase_1B	14,45	I-kappa-Balpha	94,108	protein tyrosine phosphatase 1B	I-kappa-Balpha	5770	4792	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	NGF-activated protein_tyrosine_phosphatase_1B mediates the phosphorylation and degradation of I-kappa-Balpha coupled to NF-kappa-B activation , thereby controlling dendrite morphology .
23702782	0	protein_tyrosine_phosphatase_1B	8,39	IGF-I	50,55	protein tyrosine phosphatase 1B	IGF-I	19246(Tax:10090)	16000(Tax:10090)	Gene	Gene	increases|amod|START_ENTITY Loss|nmod|increases END_ENTITY|nsubj|Loss	Loss of protein_tyrosine_phosphatase_1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal_defects in IRS2-deficient mice .
24948418	0	protein_tyrosine_phosphatase_1B	73,104	JAK2	37,41	protein tyrosine phosphatase 1B	JAK2	19246(Tax:10090)	16452(Tax:10090)	Gene	Gene	signalling|nmod|START_ENTITY END_ENTITY|acl|signalling	Regulation of growth_hormone induced JAK2 and mTOR signalling by hepatic protein_tyrosine_phosphatase_1B .
12617932	0	protein_tyrosine_phosphatase_1B	49,80	PTP1B	82,87	protein tyrosine phosphatase 1B	PTP1B	5770	5770	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Modification of the N-terminus of peptidomimetic protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- inhibitors : identification of analogues with cellular activity .
16076179	0	protein_tyrosine_phosphatase_1B	41,72	PTP1B	74,79	protein tyrosine phosphatase 1B	PTP1B	5770	5770	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	A chemical model for redox regulation of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- activity .
21571537	0	protein_tyrosine_phosphatase_1B	54,85	PTP1B	87,92	protein tyrosine phosphatase 1B	PTP1B	5770	5770	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	New 5-deoxyflavonoids and their inhibitory effects on protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- activity .
22263876	0	protein_tyrosine_phosphatase_1B	34,65	PTP1B	67,72	protein tyrosine phosphatase 1B	PTP1B	5770	5770	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Specific inhibition of sensitized protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- with a biarsenical probe .
23022281	0	protein_tyrosine_phosphatase_1B	32,63	PTP1B	65,70	protein tyrosine phosphatase 1B	PTP1B	5770	5770	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	New prenylated isoflavonoids as protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- inhibitors from Erythrina addisoniae .
24625984	0	protein_tyrosine_phosphatase_1B	16,47	PTP1B	49,54	protein tyrosine phosphatase 1B	PTP1B	5770	5770	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Pivotal role of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- in the macrophage response to pro-inflammatory and anti-inflammatory challenge .
17634210	0	protein_tyrosine_phosphatase_1B	25,56	PTPN1	58,63	protein tyrosine phosphatase 1B	PTPN1	5770	5770	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms within the protein_tyrosine_phosphatase_1B -LRB- PTPN1 -RRB- gene promoter : functional characterization and association with type_2_diabetes and related metabolic traits .
21538175	0	protein_tyrosine_phosphatase_1B	174,205	RBP4	245,249	protein tyrosine phosphatase 1B	RBP4	19246(Tax:10090)	19662(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Susceptibility to diet-induced obesity and glucose_intolerance in the APP -LRB- SWE -RRB- / PSEN1 -LRB- A246E -RRB- mouse model of Alzheimer 's _ disease is associated with increased brain levels of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- and retinol-binding_protein_4 -LRB- RBP4 -RRB- , and basal phosphorylation of S6 ribosomal protein .
17339486	0	protein_tyrosine_phosphatase_1B	38,69	VCAM-1	0,6	protein tyrosine phosphatase 1B	VCAM-1	5770	7412	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	VCAM-1 activation of endothelial cell protein_tyrosine_phosphatase_1B .
17576811	0	protein_tyrosine_phosphatase_1B	29,60	calpain-1	90,99	protein tyrosine phosphatase 1B	calpain-1	19246(Tax:10090)	12333(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Double knockouts reveal that protein_tyrosine_phosphatase_1B is a physiological target of calpain-1 in platelets .
16828971	0	protein_tyrosine_phosphatase_1B	40,71	insulin_receptor	83,99	protein tyrosine phosphatase 1B	insulin receptor	5770	3643	Gene	Gene	inhibit|xcomp|START_ENTITY inhibit|ccomp|enhancing enhancing|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Ursolic_acid and its derivative inhibit protein_tyrosine_phosphatase_1B , enhancing insulin_receptor phosphorylation and stimulating glucose uptake .
21466649	0	protein_tyrosine_phosphatase_1B	94,125	insulin_receptor	53,69	protein tyrosine phosphatase 1B	insulin receptor	24697(Tax:10116)	24954(Tax:10116)	Gene	Gene	regulation|amod|START_ENTITY increasing|nmod|regulation increasing|dobj|phosphorylation phosphorylation|compound|END_ENTITY	Vitamin_A improves insulin sensitivity by increasing insulin_receptor phosphorylation through protein_tyrosine_phosphatase_1B regulation at early age in obese rats of WNIN/Ob strain .
21487008	0	protein_tyrosine_phosphatase_1B	52,83	insulin_receptor	127,143	protein tyrosine phosphatase 1B	insulin receptor	5770	3643	Gene	Gene	mutant|nmod|START_ENTITY reveals|nsubj|mutant reveals|dobj|autoactivation autoactivation|nmod|precursor precursor|compound|END_ENTITY	A new highly efficient substrate-trapping mutant of protein_tyrosine_phosphatase_1B -LRB- PTP1B -RRB- reveals full autoactivation of the insulin_receptor precursor .
18451337	0	protein_tyrosine_phosphatase_1B	8,39	vascular_endothelial_growth_factor	43,77	protein tyrosine phosphatase 1B	vascular endothelial growth factor	5770	7422	Gene	Gene	START_ENTITY|nmod|signaling signaling|compound|END_ENTITY	Role of protein_tyrosine_phosphatase_1B in vascular_endothelial_growth_factor signaling and cell-cell adhesions in endothelial cells .
8627166	0	protein_tyrosine_phosphatase_1C	21,52	CD22	0,4	protein tyrosine phosphatase 1C	CD22	5777	933	Gene	Gene	associates|nmod|START_ENTITY associates|nummod|END_ENTITY	CD22 associates with protein_tyrosine_phosphatase_1C , Syk , and phospholipase_C-gamma -LRB- 1 -RRB- upon B cell activation .
17130234	0	protein_tyrosine_phosphatase_PEST	72,105	Caspase-3	0,9	protein tyrosine phosphatase PEST	Caspase-3	5782	836	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Caspase-3 regulates catalytic activity and scaffolding functions of the protein_tyrosine_phosphatase_PEST , a novel modulator of the apoptotic response .
14676845	0	protein_tyrosine_phosphatase_gamma	46,80	PTPgamma	82,90	protein tyrosine phosphatase gamma	PTPgamma	5793	5793	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Function analysis of estrogenically regulated protein_tyrosine_phosphatase_gamma -LRB- PTPgamma -RRB- in human breast_cancer cell line MCF-7 .
17394498	0	protein_tyrosine_phosphatase_gamma	28,62	PTPgamma	64,72	protein tyrosine phosphatase gamma	PTPgamma	5793	5793	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of transmembrane protein_tyrosine_phosphatase_gamma -LRB- PTPgamma -RRB- in normal and neoplastic human tissues .
16404719	0	protein_tyrosine_phosphatase_kappa	114,148	N-acetylglucosaminyl_transferase_V	37,71	protein tyrosine phosphatase kappa	N-acetylglucosaminyl transferase V	5796	4249	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of target proteins of N-acetylglucosaminyl_transferase_V in human colon_cancer and implications of protein_tyrosine_phosphatase_kappa in enhanced cancer cell migration .
17909891	0	protein_tyrosine_phosphatase_kappa	27,61	Ptprk	63,68	protein tyrosine phosphatase kappa	Ptprk	360302(Tax:10116)	360302(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A deletion mutation of the protein_tyrosine_phosphatase_kappa -LRB- Ptprk -RRB- gene is responsible for T-helper immunodeficiency -LRB- thid -RRB- in the LEC rat .
11860281	0	protein_tyrosine_phosphatase_mu	50,81	Protein_kinase_C_delta	0,22	protein tyrosine phosphatase mu	Protein kinase C delta	5797	5580	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Protein_kinase_C_delta -LRB- PKCdelta -RRB- is required for protein_tyrosine_phosphatase_mu -LRB- PTPmu -RRB- - dependent neurite outgrowth .
18578611	0	protein_tyrosine_phosphatase_nonreceptor_22	16,59	PTPN22	61,67	protein tyrosine phosphatase nonreceptor 22	PTPN22	26191	26191	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations of protein_tyrosine_phosphatase_nonreceptor_22 -LRB- PTPN22 -RRB- gene polymorphisms with susceptibility to Graves ' _ disease in a Japanese population .
11719468	0	proteinase	27,37	Endothelin-1	0,12	proteinase	Endothelin-1	100616101	1906	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Endothelin-1 induces tumor proteinase activation and invasiveness_of_ovarian_carcinoma cells .
11943586	0	proteinase	28,38	LEKTI	0,5	proteinase	LEKTI	100616101	11005	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|dep|inhibitor	LEKTI : a multidomain serine proteinase inhibitor with pathophysiological relevance .
20069636	0	proteinase	17,27	LEKTI	38,43	proteinase	LEKTI	100616101	11005	Gene	Gene	inhibitor|amod|START_ENTITY Synthesis|nmod|inhibitor END_ENTITY|nsubj|Synthesis	Synthesis of the proteinase inhibitor LEKTI domain 6 by the fragment condensation method and regioselective disulfide bond formation .
21997416	0	proteinase	86,96	LEKTI	36,41	proteinase	LEKTI	100616101	11005	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	When activity requires breaking up : LEKTI proteolytic activation cascade for specific proteinase inhibition .
9727401	0	proteinase	61,71	cathepsin_V	40,51	proteinase	cathepsin V	100616101	1515	Gene	Gene	Isolation|dep|START_ENTITY Isolation|nmod|END_ENTITY	Isolation and characterization of human cathepsin_V : a major proteinase in corneal epithelium .
12479412	0	proteinase	15,25	cystatin_C	67,77	proteinase	cystatin C	100616101	1471	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Enhancement of proteinase inhibitory activity of recombinant human cystatin_C using random-centroid optimization .
11214923	0	proteinase	30,40	prion_protein	65,78	proteinase	prion protein	100616101	5621	Gene	Gene	form|amod|START_ENTITY form|nmod|END_ENTITY	Specific determination of the proteinase K-resistant form of the prion_protein using two-site immunometric assays .
20685328	1	proteinase	116,126	proteinase	163,173	proteinase	proteinase	100616101	100616101	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|amod|END_ENTITY	A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors .
20685328	1	proteinase	163,173	proteinase	116,126	proteinase	proteinase	100616101	100616101	Gene	Gene	inhibitors|amod|START_ENTITY END_ENTITY|nmod|inhibitors	A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors .
8393902	0	proteinase	88,98	stratum_corneum_chymotryptic_enzyme	49,84	proteinase	stratum corneum chymotryptic enzyme	100616101	5650	Gene	Gene	characterization|dep|START_ENTITY characterization|nmod|END_ENTITY	Purification and preliminary characterization of stratum_corneum_chymotryptic_enzyme : a proteinase that may be involved in desquamation .
9336411	0	proteinase	60,70	thrombospondin_1	32,48	proteinase	thrombospondin 1	100616101	7057	Gene	Gene	START_ENTITY|nsubj|correlation correlation|nmod|END_ENTITY	Significant correlation between thrombospondin_1 and serine proteinase expression in rheumatoid_synovium .
8100709	0	proteinase-3	59,71	secretory_leukocyte_protease_inhibitor	15,53	proteinase-3	secretory leukocyte protease inhibitor	5657	6590	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of secretory_leukocyte_protease_inhibitor with proteinase-3 .
21501162	0	proteinase-activated_receptor-2	8,39	interferon-y	90,102	proteinase-activated receptor-2	interferon-y	2150	3458	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of proteinase-activated_receptor-2 in anti-bacterial and immunomodulatory effects of interferon-y on human neutrophils and monocytes .
20578818	0	proteinase-activated_receptor-2	77,108	vascular_endothelial_growth_factor	27,61	proteinase-activated receptor-2	vascular endothelial growth factor	2150	7422	Gene	Gene	kinase|amod|START_ENTITY expression|nmod|kinase expression|compound|END_ENTITY	beta-Tryptase up-regulates vascular_endothelial_growth_factor expression via proteinase-activated_receptor-2 and mitogen-activated protein kinase pathways in bone marrow stromal cells in acute_myeloid_leukemia .
20128804	0	proteinase-activated_receptor_1	23,54	Thrombin	0,8	proteinase-activated receptor 1	Thrombin	2149	2147	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Thrombin activation of proteinase-activated_receptor_1 potentiates the myofilament Ca2 + sensitivity and induces vasoconstriction in porcine pulmonary arteries .
21546388	0	proteinase-activated_receptor_2	15,46	PAR2	48,52	proteinase-activated receptor 2	PAR2	2150	2150	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TGF-b1 induces proteinase-activated_receptor_2 -LRB- PAR2 -RRB- expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6 .
22411985	0	proteinase-activated_receptor_2	15,46	PAR2	48,52	proteinase-activated receptor 2	PAR2	2150	2150	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Novel role for proteinase-activated_receptor_2 -LRB- PAR2 -RRB- in membrane trafficking of proteinase-activated_receptor_4 -LRB- PAR4 -RRB- .
21546388	0	proteinase-activated_receptor_2	15,46	TGF-b1	0,6	proteinase-activated receptor 2	TGF-b1	2150	7040	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	TGF-b1 induces proteinase-activated_receptor_2 -LRB- PAR2 -RRB- expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6 .
24643912	0	proteinase-activated_receptor_2	105,136	kallikrein-related_peptidase_6	56,86	proteinase-activated receptor 2	kallikrein-related peptidase 6	2150	5653	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Growth and survival of lung_cancer cells : regulation by kallikrein-related_peptidase_6 via activation of proteinase-activated_receptor_2 and the epidermal_growth_factor_receptor .
10792393	0	proteinase_3	150,162	Granulocyte-macrophage_colony-stimulating_factor	0,48	proteinase 3	Granulocyte-macrophage colony-stimulating factor	5657	1437	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- but not granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- induces plasma membrane expression of proteinase_3 -LRB- PR3 -RRB- on neutrophils in vitro .
17244676	0	proteinase_3	52,64	NB1	0,3	proteinase 3	NB1	5657	57126	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	NB1 mediates surface expression of the ANCA antigen proteinase_3 on human neutrophils .
10103046	0	proteinase_3	30,42	PR3	44,47	proteinase 3	PR3	5657	5657	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of purified human proteinase_3 -LRB- PR3 -RRB- with reconstituted lipid bilayers .
8629812	0	proteinase_3	4,16	PRTN3	18,23	proteinase 3	PRTN3	5657	5657	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The proteinase_3 -LRB- PRTN3 -RRB- gene is localized on 19p13 .3 and is distal to the E2A gene .
9330712	0	proteinase_3	63,75	TGF_beta	48,56	proteinase 3	TGF beta	5657	7040	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of transforming_growth_factor_beta -LRB- TGF_beta -RRB- with proteinase_3 .
12067299	0	proteinase_3	6,18	TNF-alpha	45,54	proteinase 3	TNF-alpha	5657	7124	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|production production|amod|END_ENTITY	Human proteinase_3 can inhibits LPS-mediated TNF-alpha production through CD14 degradation : lack of influence of antineutrophil cytoplasmic antibodies .
19950280	0	proteinase_3	73,85	interleukin-1beta	135,152	proteinase 3	interleukin-1beta	19152(Tax:10090)	16176(Tax:10090)	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Inflammatory arthritis in caspase_1 gene-deficient mice : contribution of proteinase_3 to caspase_1-independent production of bioactive interleukin-1beta .
20412702	0	proteinase_3	9,21	mPR3	23,27	proteinase 3	mPR3	5657	19152(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Membrane proteinase_3 -LRB- mPR3 -RRB- expression on neutrophils is not increased in localized Wegener 's _ granulomatosis -LRB- WG -RRB- and Churg-Strauss_syndrome -LRB- CSS -RRB- .
2258701	0	proteinase_3	20,32	serine_protease	36,51	proteinase 3	serine protease	5657	2147	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|dep|END_ENTITY	Cloning of cDNA for proteinase_3 : a serine_protease , antibiotic , and autoantigen from human neutrophils .
9330712	0	proteinase_3	63,75	transforming_growth_factor_beta	15,46	proteinase 3	transforming growth factor beta	5657	7040	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of transforming_growth_factor_beta -LRB- TGF_beta -RRB- with proteinase_3 .
12005059	0	proteinase_A	129,141	PEP4	148,152	proteinase A	PEP4	855949(Tax:4932)	855949(Tax:4932)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Construction of protease-deficient Candida boidinii strains useful for recombinant protein production : cloning and disruption of proteinase_A gene -LRB- PEP4 -RRB- and proteinase_B gene -LRB- PRBI -RRB- .
24131465	0	proteinase_activated_receptor-2	15,46	sphingosine_1-phosphate	75,98	proteinase activated receptor-2	sphingosine 1-phosphate	14063(Tax:10090)	13609(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of proteinase_activated_receptor-2 in the vascular response to sphingosine_1-phosphate .
16245157	0	proteinase_inhibitor	79,99	PIN2	101,105	proteinase inhibitor	PIN2	102581269	102581269	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assessment of nematode resistance in wheat transgenic plants expressing potato proteinase_inhibitor -LRB- PIN2 -RRB- gene .
19956856	0	proteinase_inhibitor-9	14,36	serpinB9	37,45	proteinase inhibitor-9	serpinB9	5272	5272	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of proteinase_inhibitor-9 / serpinB9 in non-small_cell_lung_carcinoma cells and tissues .
9442015	0	proteinase_inhibitor_8	49,71	furin	34,39	proteinase inhibitor 8	furin	5271	5045	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of soluble recombinant furin by human proteinase_inhibitor_8 .
11278311	0	proteinase_inhibitor_9	116,138	granzyme_B	39,49	proteinase inhibitor 9	granzyme B	5272	3002	Gene	Gene	loop|amod|START_ENTITY mutagenesis|nmod|loop scanning|dobj|mutagenesis revealed|advcl|scanning revealed|nsubj|Importance Importance|nmod|residue residue|nmod|inhibitors inhibitors|compound|END_ENTITY	Importance of the P4 ' residue in human granzyme_B inhibitors and substrates revealed by scanning mutagenesis of the proteinase_inhibitor_9 reactive center loop .
12517944	0	proteinase_inhibitor_9	40,62	granzyme_B	18,28	proteinase inhibitor 9	granzyme B	5272	3002	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|compound|END_ENTITY	The intracellular granzyme_B inhibitor , proteinase_inhibitor_9 , is up-regulated during accessory cell maturation and effector cell degranulation , and its overexpression enhances CTL potency .
16306080	0	proteinase_inhibitor_9	48,70	granzyme_B	26,36	proteinase inhibitor 9	granzyme B	5272	3002	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	Estrogen induction of the granzyme_B inhibitor , proteinase_inhibitor_9 , protects cells against apoptosis mediated by cytotoxic T lymphocytes and natural killer cells .
2186666	0	proteoglycan	31,43	PG-M	45,49	proteoglycan	PG-M	395565(Tax:9031)	395565(Tax:9031)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of mesenchyme proteoglycan -LRB- PG-M -RRB- during wing bud outgrowth .
2436234	0	proteoglycan	2,14	cytotactin	83,93	proteoglycan	cytotactin	395565(Tax:9031)	396440(Tax:9031)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	A proteoglycan with HNK-1 antigenic determinants is a neuron-associated ligand for cytotactin .
21041994	0	proteoglycan-4	27,41	IL-1a	56,61	proteoglycan-4	IL-1a	289104(Tax:10116)	24493(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Differential regulation of proteoglycan-4 expression by IL-1a and TGF-b1 in rat condylar chondrocytes .
11124536	0	proteoglycan_4	69,83	PRG4	63,67	proteoglycan 4	PRG4	10216	10216	Gene	Gene	genes|nummod|START_ENTITY genes|compound|END_ENTITY	Isolation , characterization and mapping of the mouse and human PRG4 -LRB- proteoglycan_4 -RRB- genes .
8333831	0	proteoglycan_core_protein	11,36	PCP	38,41	proteoglycan core protein	PCP	1634	1634	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in proteoglycan_core_protein -LRB- PCP -RRB- mRNA levels during HL-60 cell differentiation .
10818135	0	proteolipid_protein	88,107	DM-20	67,72	proteolipid protein	DM-20	5354	18823(Tax:10090)	Gene	Gene	replace|dobj|START_ENTITY replace|nsubj|END_ENTITY	The evolution of lipophilin genes from invertebrates to tetrapods : DM-20 can not replace proteolipid_protein in CNS myelin .
10441741	0	proteolipid_protein	34,53	PLP	55,58	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular analysis of the porcine proteolipid_protein -LRB- PLP -RRB- gene .
10826694	0	proteolipid_protein	60,79	PLP	81,84	proteolipid protein	PLP	281410(Tax:9913)	281410(Tax:9913)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structural analysis and transcript processing of the bovine proteolipid_protein -LRB- PLP -RRB- gene .
1376553	0	proteolipid_protein	29,48	PLP	50,53	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	New variant in exon 3 of the proteolipid_protein -LRB- PLP -RRB- gene in a family with Pelizaeus-Merzbacher_disease .
1378839	0	proteolipid_protein	56,75	PLP	77,80	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of cis-regulatory elements in the myelin proteolipid_protein -LRB- PLP -RRB- gene .
1707231	0	proteolipid_protein	22,41	PLP	43,46	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new mutation in the proteolipid_protein -LRB- PLP -RRB- gene in a German family with Pelizaeus-Merzbacher_disease .
1719156	0	proteolipid_protein	24,43	PLP	45,48	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Induction of the myelin proteolipid_protein -LRB- PLP -RRB- gene in C6 glioblastoma cells : functional analysis of the PLP promotor .
7541731	0	proteolipid_protein	64,83	PLP	85,88	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Pelizaeus-Merzbacher_disease : a point mutation in exon 6 of the proteolipid_protein -LRB- PLP -RRB- gene .
7705847	0	proteolipid_protein	25,44	PLP	46,49	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	MvaI polymorphism in the proteolipid_protein -LRB- PLP -RRB- gene .
9747038	0	proteolipid_protein	76,95	PLP	97,100	proteolipid protein	PLP	5354	5354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Connatal Pelizaeus-Merzbacher_disease : a missense mutation in exon 4 of the proteolipid_protein -LRB- PLP -RRB- gene .
11180600	0	proteolipid_protein	26,45	PLP1	47,51	proteolipid protein	PLP1	5354	5354	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new polymorphism in the proteolipid_protein -LRB- PLP1 -RRB- gene and its use for carrier detection of PLP1 gene duplication in Pelizaeus-Merzbacher_disease .
12966435	0	proteolysis-inducing_factor	79,106	PIF	108,111	proteolysis-inducing factor	PIF	100126829(Tax:10090)	100126829(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing_factor -LRB- PIF -RRB- is associated with activation of the transcription factor NF-kappaB .
17572893	0	prothrombin	28,39	Factor_V_Leiden	0,15	prothrombin	Factor V Leiden	2147	2153	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Factor_V_Leiden and G20210A prothrombin mutations in patients with recurrent_pregnancy_loss : data from the southeast of Turkey .
6439669	0	prothrombin	100,111	Factor_Xa	115,124	prothrombin	Factor Xa	2147	2159	Gene	Gene	proteolysis|nmod|START_ENTITY accompanying|dobj|proteolysis accompanying|nmod|END_ENTITY	Origin of a fluorescence increase accompanying the limited proteolysis of fluorescein-labeled human prothrombin by Factor_Xa .
14531686	0	prothrombin	180,191	antithrombin	150,162	prothrombin	antithrombin	2147	462	Gene	Gene	peptide|nmod|START_ENTITY peptide|compound|END_ENTITY	Probing the kinetic landscape of transient peptide-protein interactions by use of peptide -LRB- 15 -RRB- n NMR relaxation dispersion spectroscopy : binding of an antithrombin peptide to human prothrombin .
17290027	0	prothrombin	21,32	factor_V_Leiden	4,19	prothrombin	factor V Leiden	2147	2153	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	The factor_V_Leiden , prothrombin gene 20210GA , methylenetetrahydrofolate_reductase 677CT and platelet glycoprotein IIIa 1565TC mutations in patients with acute ischemic_stroke and atrial_fibrillation .
15897196	0	prothrombin	87,98	factor_Xa	102,111	prothrombin	factor Xa	2147	2159	Gene	Gene	cleavage|nmod|START_ENTITY required|nmod|cleavage required|nmod|END_ENTITY	Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor_Xa .
16042383	0	prothrombin	148,159	factor_Xa	65,74	prothrombin	factor Xa	2147	2159	Gene	Gene	site|nmod|START_ENTITY evidence|dep|site mapping|dep|evidence mapping|nmod|residues residues|nmod|sequence sequence|nmod|END_ENTITY	Functional mapping of charged residues of the 82-116 sequence in factor_Xa : evidence that lysine 96 is a factor Va independent recognition site for prothrombin in the prothrombinase complex .
3787558	0	prothrombin	21,32	factor_Xa	80,89	prothrombin	factor Xa	2147	2159	Gene	Gene	variant|compound|START_ENTITY variant|nmod|END_ENTITY	Prothrombin Clamart : prothrombin variant with defective Arg 320-IIe cleavage by factor_Xa .
489543	0	prothrombin	36,47	factor_Xa	69,78	prothrombin	factor Xa	2147	2159	Gene	Gene	activation|nmod|START_ENTITY Kinetics|nmod|activation Kinetics|nmod|END_ENTITY	Kinetics of the activation of human prothrombin by human coagulation factor_Xa .
7852276	0	prothrombin	88,99	factor_Xa	18,27	prothrombin	factor Xa	2147	2159	Gene	Gene	domain|nmod|START_ENTITY sequence|nmod|domain interacts|nmod|sequence interacts|nsubj|END_ENTITY	Blood_coagulation factor_Xa interacts with a linear sequence of the kringle 2 domain of prothrombin .
11278943	0	prothrombin	11,22	prothrombinase	91,105	prothrombin	prothrombinase	2147	2159	Gene	Gene	use|nmod|START_ENTITY labeled|nsubj|use labeled|xcomp|study study|dobj|inhibition inhibition|nmod|END_ENTITY	The use of prothrombin -LRB- S525C -RRB- labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation .
11278943	0	prothrombin	129,140	prothrombinase	91,105	prothrombin	prothrombinase	2147	2159	Gene	Gene	activation|compound|START_ENTITY study|nmod|activation study|dobj|inhibition inhibition|nmod|END_ENTITY	The use of prothrombin -LRB- S525C -RRB- labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation .
12750382	0	prothrombin	16,27	prothrombinase	78,92	prothrombin	prothrombinase	2147	2159	Gene	Gene	Proexosite-1|nmod|START_ENTITY site|nsubj|Proexosite-1 site|nmod|complex complex|amod|END_ENTITY	Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex .
15897196	0	prothrombin	87,98	prothrombinase	32,46	prothrombin	prothrombinase	2147	2159	Gene	Gene	cleavage|nmod|START_ENTITY required|nmod|cleavage required|nsubjpass|Incorporation Incorporation|nmod|Va Va|nmod|END_ENTITY	Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor_Xa .
16006504	0	prothrombin	108,119	prothrombinase	123,137	prothrombin	prothrombinase	2147	2159	Gene	Gene	cleavage|nmod|START_ENTITY directs|dobj|cleavage directs|nmod|END_ENTITY	Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase .
17848548	0	prothrombin	90,101	prothrombinase	105,119	prothrombin	prothrombinase	2147	2159	Gene	Gene	cleavage|nmod|START_ENTITY enforces|dobj|cleavage enforces|nmod|END_ENTITY	Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase .
21531712	0	prothrombin	20,31	prothrombinase	41,55	prothrombin	prothrombinase	2147	14190(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo .
23940050	0	prothrombin	20,31	prothrombinase	73,87	prothrombin	prothrombinase	2147	2159	Gene	Gene	binding|nmod|START_ENTITY mediates|nsubj|binding mediates|advcl|END_ENTITY	Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage .
21469939	0	prothrombinase	4,18	FGL2	31,35	prothrombinase	FGL2	14190(Tax:10090)	14190(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	The prothrombinase activity of FGL2 contributes to the pathogenesis of experimental arthritis .
7836355	0	prothrombinase	26,40	Prothrombin	0,11	prothrombinase	Prothrombin	2159	2147	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|END_ENTITY	Prothrombin activation by prothrombinase in a tubular flow reactor .
9167017	0	prothrombinase	48,62	Prothrombin	0,11	prothrombinase	Prothrombin	2159	2147	Gene	Gene	conditions|nmod|START_ENTITY conversion|nmod|conditions conversion|compound|END_ENTITY	Prothrombin conversion under flow conditions by prothrombinase assembled on adherent platelets .
7559509	0	prothrombinase	74,88	factor_Xa	57,66	prothrombinase	factor Xa	2159	2159	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Protease nexin-2 / amyloid beta-protein precursor inhibits factor_Xa in the prothrombinase complex .
9782336	0	prothrombinase	48,62	fgl2	18,22	prothrombinase	fgl2	14190(Tax:10090)	14190(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the fgl2 and its protein product -LRB- prothrombinase -RRB- in tissues during murine hepatitis virus strain-3 -LRB- MHV-3 -RRB- infection .
11278943	0	prothrombinase	91,105	prothrombin	11,22	prothrombinase	prothrombin	2159	2147	Gene	Gene	inhibition|nmod|START_ENTITY study|dobj|inhibition labeled|xcomp|study labeled|nsubj|use use|nmod|END_ENTITY	The use of prothrombin -LRB- S525C -RRB- labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation .
11278943	0	prothrombinase	91,105	prothrombin	129,140	prothrombinase	prothrombin	2159	2147	Gene	Gene	inhibition|nmod|START_ENTITY study|dobj|inhibition study|nmod|activation activation|compound|END_ENTITY	The use of prothrombin -LRB- S525C -RRB- labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation .
12750382	0	prothrombinase	78,92	prothrombin	16,27	prothrombinase	prothrombin	2159	2147	Gene	Gene	complex|amod|START_ENTITY site|nmod|complex site|nsubj|Proexosite-1 Proexosite-1|nmod|END_ENTITY	Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex .
15897196	0	prothrombinase	32,46	prothrombin	87,98	prothrombinase	prothrombin	2159	2147	Gene	Gene	Va|nmod|START_ENTITY Incorporation|nmod|Va required|nsubjpass|Incorporation required|nmod|cleavage cleavage|nmod|END_ENTITY	Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor_Xa .
16006504	0	prothrombinase	123,137	prothrombin	108,119	prothrombinase	prothrombin	2159	2147	Gene	Gene	directs|nmod|START_ENTITY directs|dobj|cleavage cleavage|nmod|END_ENTITY	Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase .
17848548	0	prothrombinase	105,119	prothrombin	90,101	prothrombinase	prothrombin	2159	2147	Gene	Gene	enforces|nmod|START_ENTITY enforces|dobj|cleavage cleavage|nmod|END_ENTITY	Restricted active site docking by enzyme-bound substrate enforces the ordered cleavage of prothrombin by prothrombinase .
21531712	0	prothrombinase	41,55	prothrombin	20,31	prothrombinase	prothrombin	14190(Tax:10090)	2147	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo .
23940050	0	prothrombinase	73,87	prothrombin	20,31	prothrombinase	prothrombin	2159	2147	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|binding binding|nmod|END_ENTITY	Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage .
12579833	0	prothymosin_alpha	23,40	IFN-gamma	57,66	prothymosin alpha	IFN-gamma	19231(Tax:10090)	15978(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of recombinant prothymosin_alpha on secretion of IFN-gamma , IFN-alpha and TNF-alpha in vitro -RSB- .
7798020	0	prothyrotrophin-releasing_hormone	58,91	proTRH	93,99	prothyrotrophin-releasing hormone	proTRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Starvation-induced changes in the hypothalamic content of prothyrotrophin-releasing_hormone -LRB- proTRH -RRB- mRNA and the hypothalamic release of proTRH-derived peptides : role of the adrenal gland .
9075462	0	protirelin	54,64	thyrotropin-releasing_hormone	23,52	protirelin	thyrotropin-releasing hormone	7200	7200	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of intrathecal thyrotropin-releasing_hormone -LRB- protirelin -RRB- in refractory depressed patients .
2542296	0	proto-oncogene_c-jun	32,52	Nerve_growth_factor	0,19	proto-oncogene c-jun	Nerve growth factor	24516(Tax:10116)	310738(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Nerve_growth_factor induces the proto-oncogene_c-jun in PC12 cells .
2119001	0	proto-oncogene_c-jun	17,37	angiotensin_II	41,55	proto-oncogene c-jun	angiotensin II	24516(Tax:10116)	24179(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of the proto-oncogene_c-jun by angiotensin_II .
8607968	0	proto-oncogene_c-mos	54,74	Oct-3	100,105	proto-oncogene c-mos	Oct-3	17451(Tax:10090)	18999(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Primate reproductive organs reveal a novel pattern of proto-oncogene_c-mos and transcription factor Oct-3 mRNA expression .
12070150	0	proto-oncogene_c-myc	4,24	p27	82,85	proto-oncogene c-myc	p27	4609	10671	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The proto-oncogene_c-myc acts through the cyclin-dependent kinase -LRB- Cdk -RRB- inhibitor p27 -LRB- Kip1 -RRB- to facilitate the activation of Cdk4/6 and early G -LRB- 1 -RRB- phase progression .
7835139	0	proto-oncogene_c-myc	15,35	tumor_necrosis_factor-alpha	70,97	proto-oncogene c-myc	tumor necrosis factor-alpha	4609	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	-LSB- Inhibition of proto-oncogene_c-myc expression with recombinant human tumor_necrosis_factor-alpha and interferon-gamma in HL-60 cell lines and acute myelocytic_leukemic fresh cells -RSB- .
15749076	0	protocadherin	46,59	Fat	66,69	protocadherin	Fat	406172(Tax:7955)	406172(Tax:7955)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning and expression of the large zebrafish protocadherin gene , Fat .
18729229	0	protocadherin-1	14,29	Pcdh1	31,36	protocadherin-1	Pcdh1	75599(Tax:10090)	75599(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of protocadherin-1 -LRB- Pcdh1 -RRB- during mouse development .
23321168	0	protocadherin-10	40,56	PCDH10	58,64	protocadherin-10	PCDH10	57575	57575	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Clinical and prognostic significance of protocadherin-10 -LRB- PCDH10 -RRB- promoter methylation in bladder_cancer .
24940003	0	protocadherin-15	19,35	CD2	4,7	protocadherin-15	CD2	65217	914	Gene	Gene	isoform|nmod|START_ENTITY isoform|compound|END_ENTITY	The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells .
23569129	0	protocadherin-8	25,40	PCDH8	42,47	protocadherin-8	PCDH8	5100	5100	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Clinical significance of protocadherin-8 -LRB- PCDH8 -RRB- promoter methylation in bladder_cancer .
19151506	0	protocadherin_15	97,113	Pcdh15	115,121	protocadherin 15	Pcdh15	690865(Tax:10116)	690865(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the Kyoto circling -LRB- KCI -RRB- rat carrying a spontaneous nonsense mutation in the protocadherin_15 -LRB- Pcdh15 -RRB- gene .
25114259	0	protocadherin_15	17,33	TMC1	85,89	protocadherin 15	TMC1	368476(Tax:7955)	567237(Tax:7955)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Tip-link protein protocadherin_15 interacts with transmembrane channel-like proteins TMC1 and TMC2 .
12884975	0	protocadherin_8	20,35	PCDH8	37,42	protocadherin 8	PCDH8	5100	5100	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Screening the human protocadherin_8 -LRB- PCDH8 -RRB- gene in schizophrenia .
12230809	0	proton_pump	37,48	ATP1AL1	14,21	proton pump	ATP1AL1	479	479	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of ATP1AL1 , a non-gastric proton_pump , in human colorectum .
12655566	0	protoporphyrinogen_oxidase	100,126	PPOX	128,132	protoporphyrinogen oxidase	PPOX	5498	5498	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic analysis of variegate_porphyria -LRB- VP -RRB- in Italy : identification of six novel mutations in the protoporphyrinogen_oxidase -LRB- PPOX -RRB- gene .
8575762	0	protoporphyrinogen_oxidase	10,36	PPOX	43,47	protoporphyrinogen oxidase	PPOX	5498	5498	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human protoporphyrinogen_oxidase gene -LRB- PPOX -RRB- : organization and location to chromosome 1 .
17234762	0	prx1	6,10	Nrf2	31,35	prx1	Nrf2	5052	4780	Gene	Gene	gene|amod|START_ENTITY target|nsubj|gene target|nmod|END_ENTITY	Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation : implication to tumor biology .
24675077	0	psoralen_4	22,32	hPso4	34,39	psoralen 4	hPso4	27339	27339	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The role of the human psoralen_4 -LRB- hPso4 -RRB- protein complex in replication stress and homologous recombination .
26653889	0	psoriasis_susceptibility_1_candidate_1	26,64	PSORS1C1	66,74	psoriasis susceptibility 1 candidate 1	PSORS1C1	170679	170679	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism within the psoriasis_susceptibility_1_candidate_1 -LRB- PSORS1C1 -RRB- gene is not linked to HLA-B * 58:01 in an Australian cohort .
10395791	0	ptc1	18,22	Shh	45,48	ptc1	Shh	5727	6469	Gene	Gene	Overexpression|nmod|START_ENTITY inhibits|nsubj|Overexpression inhibits|dobj|induction induction|nmod|genes genes|compound|END_ENTITY	Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube .
9760199	0	pterin-4alpha-carbinolamine_dehydratase	17,56	PCBD	58,62	pterin-4alpha-carbinolamine dehydratase	PCBD	5092	5092	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the pterin-4alpha-carbinolamine_dehydratase -LRB- PCBD -RRB- gene cause a benign form of hyperphenylalaninemia .
11435617	0	pth	118,121	PTHrP	144,149	pth	PTHrP	5741	5744	Gene	Gene	domains|nmod|START_ENTITY role|nmod|domains differentiates|dobj|role Analysis|dep|differentiates Analysis|dep|receptor receptor|appos|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
11435617	0	pth-related_peptide	123,142	PTHrP	144,149	pth-related peptide	PTHrP	5744	5744	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
11435617	0	pth-related_peptide	123,142	parathyroid_hormone	12,31	pth-related peptide	parathyroid hormone	5744	5741	Gene	Gene	receptor|amod|START_ENTITY Analysis|dep|receptor Analysis|nmod|END_ENTITY	Analysis of parathyroid_hormone -LRB- PTH -RRB- / secretin_receptor chimeras differentiates the role of functional domains in the pth / pth-related_peptide -LRB- PTHrP -RRB- receptor on hormone binding and receptor activation .
9811450	0	pttg	32,36	hpttg	0,5	pttg	hpttg	64193(Tax:10116)	9232	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	hpttg , a human homologue of rat pttg , is overexpressed in hematopoietic_neoplasms .
19958819	0	pulmonary_activation-regulated_chemokine	23,63	CC-chemokine_ligand_18	0,22	pulmonary activation-regulated chemokine	CC-chemokine ligand 18	6362	6362	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	CC-chemokine_ligand_18 / pulmonary_activation-regulated_chemokine expression in the CNS with special reference to traumatic_brain_injuries and neoplastic_disorders .
11713256	0	pulmonary_surfactant_protein-A	64,94	SP-A	96,100	pulmonary surfactant protein-A	SP-A	653509	653509	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary_surfactant_protein-A -LRB- SP-A -RRB- gene by thyroid_transcription_factor-1 -LRB- TTF-1 -RRB- .
9475280	0	pulmonary_surfactant_protein_A	15,45	SP-A	47,51	pulmonary surfactant protein A	SP-A	653509	653509	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of pulmonary_surfactant_protein_A -LRB- SP-A -RRB- gene and respiratory_distress_syndrome : interaction with SP-B .
3120506	0	purine_nucleoside_phosphorylase	39,70	PNP	72,75	purine nucleoside phosphorylase	PNP	4860	4860	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	8-Amino-9-substituted_guanines : potent purine_nucleoside_phosphorylase -LRB- PNP -RRB- inhibitors .
8931706	0	purine_nucleoside_phosphorylase	68,99	PNP	101,104	purine nucleoside phosphorylase	PNP	4860	4860	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two novel missense and frameshift mutations in exons 5 and 6 of the purine_nucleoside_phosphorylase -LRB- PNP -RRB- gene in a severe_combined_immunodeficiency -LRB- SCID -RRB- patient .
26151598	0	purinergic_receptor_P2X3	48,72	Pirt	0,4	purinergic receptor P2X3	Pirt	228139(Tax:10090)	193003(Tax:10090)	Gene	Gene	reduces|nmod|START_ENTITY reduces|nsubj|END_ENTITY	Pirt reduces bladder_overactivity by inhibiting purinergic_receptor_P2X3 .
10784606	0	px19	40,44	PRELI	0,5	px19	PRELI	27166	27166	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	PRELI , the human homologue of the avian px19 , is expressed by germinal center B lymphocytes .
23606517	0	pyhin1	44,50	pyrin_and_HIN_domain_family_member_1	6,42	pyhin1	pyrin and HIN domain family member 1	236312(Tax:10090)	236312;54483	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Mouse pyrin_and_HIN_domain_family_member_1 -LRB- pyhin1 -RRB- protein positively regulates LPS-induced IFN-b and NO production in macrophages .
10430614	0	pyk2	28,32	TNF	94,97	pyk2	TNF	2185	7124	Gene	Gene	kinase|dobj|START_ENTITY kinase|nmod|END_ENTITY	Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF .
23606517	0	pyrin_and_HIN_domain_family_member_1	6,42	pyhin1	44,50	pyrin and HIN domain family member 1	pyhin1	236312;54483	236312(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Mouse pyrin_and_HIN_domain_family_member_1 -LRB- pyhin1 -RRB- protein positively regulates LPS-induced IFN-b and NO production in macrophages .
15305021	0	pyroglutamyl_aminopeptidase_I	24,53	thyrotropin-releasing_hormone	71,100	pyroglutamyl aminopeptidase I	thyrotropin-releasing hormone	290648(Tax:10116)	25569(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Marginal involvement of pyroglutamyl_aminopeptidase_I in metabolism of thyrotropin-releasing_hormone in rat brain .
8071580	0	pyrophosphatase	38,53	alkaline_phosphatase	17,37	pyrophosphatase	alkaline phosphatase	5464	250	Gene	Gene	activity|compound|START_ENTITY activity|amod|END_ENTITY	-LSB- Implications of alkaline_phosphatase pyrophosphatase activity : intracellular functions of alkaline_phosphatase -RSB- .
8071580	0	pyrophosphatase	38,53	alkaline_phosphatase	91,111	pyrophosphatase	alkaline phosphatase	5464	250	Gene	Gene	activity|compound|START_ENTITY Implications|nmod|activity Implications|dep|functions functions|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Implications of alkaline_phosphatase pyrophosphatase activity : intracellular functions of alkaline_phosphatase -RSB- .
3732509	0	pyruvate_carboxylase	59,79	Avidin	0,6	pyruvate carboxylase	Avidin	374263(Tax:9031)	396260(Tax:9031)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Avidin as a probe of the conformational changes induced in pyruvate_carboxylase by acetyl-CoA and pyruvate .
7698008	0	pyruvate_carboxylase	24,44	PC	51,53	pyruvate carboxylase	PC	5091	5091	Gene	Gene	gene|compound|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of the human pyruvate_carboxylase gene -LRB- PC -RRB- to 11q13 .4 by fluorescence in situ hybridisation .
15917242	0	pyruvate_carboxylase	70,90	peroxisome_proliferator-activated_receptor-gamma	4,52	pyruvate carboxylase	peroxisome proliferator-activated receptor-gamma	18563(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The peroxisome_proliferator-activated_receptor-gamma regulates murine pyruvate_carboxylase gene expression in vivo and in vitro .
11991544	0	pyruvate_dehydrogenase	14,36	PDH	38,41	pyruvate dehydrogenase	PDH	54704	54704	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regulation of pyruvate_dehydrogenase -LRB- PDH -RRB- activity in human skeletal muscle during exercise .
8936413	0	pyruvate_dehydrogenase	44,66	PDH	77,80	pyruvate dehydrogenase	PDH	54704	54704	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Effect of duration of cerebral_ischemia on pyruvate_dehydrogenase activity -LRB- PDH -RRB- and metabolites in the gerbil brain -RSB- .
25088999	0	pyruvate_dehydrogenase	39,61	PHD3	19,23	pyruvate dehydrogenase	PHD3	54704	112399	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Prolyl-hydroxylase PHD3 interacts with pyruvate_dehydrogenase -LRB- PDH -RRB- - E1b and regulates the cellular PDH activity .
11708858	0	pyruvate_dehydrogenase	27,49	Pdha1	51,56	pyruvate dehydrogenase	Pdha1	18597(Tax:10090)	18597(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inactivation of the murine pyruvate_dehydrogenase -LRB- Pdha1 -RRB- gene and its effect on early embryonic development .
11577086	0	pyruvate_dehydrogenase	109,131	insulin	86,93	pyruvate dehydrogenase	insulin	54704	3630	Gene	Gene	activity|amod|START_ENTITY stimulation|nmod|activity stimulation|compound|END_ENTITY	Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate_dehydrogenase complex activity in muscle and liver cells .
9438382	0	pyruvate_dehydrogenase	29,51	insulin	64,71	pyruvate dehydrogenase	insulin	54704	3630	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	G proteins and regulation of pyruvate_dehydrogenase activity by insulin in human circulating lymphocytes .
10542321	0	pyruvate_dehydrogenase_alpha-subunit	83,119	PDHA-2	121,127	pyruvate dehydrogenase alpha-subunit	PDHA-2	5161	5161	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the regulatory region of the human testis-specific form of the pyruvate_dehydrogenase_alpha-subunit -LRB- PDHA-2 -RRB- gene .
15047604	0	pyruvate_dehydrogenase_kinase-4	38,69	Protein_kinase_B-alpha	0,22	pyruvate dehydrogenase kinase-4	Protein kinase B-alpha	5166	207	Gene	Gene	induction|amod|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Protein_kinase_B-alpha inhibits human pyruvate_dehydrogenase_kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors .
24395567	0	pyruvate_dehydrogenase_kinase_1	52,83	PDK1	85,89	pyruvate dehydrogenase kinase 1	PDK1	116551(Tax:10116)	116551(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Resveratrol restores sirtuin_1 -LRB- SIRT1 -RRB- activity and pyruvate_dehydrogenase_kinase_1 -LRB- PDK1 -RRB- expression after hemorrhagic_injury in a rat model .
26740179	0	pyruvate_dehydrogenase_kinase_4	23,54	JNK	104,107	pyruvate dehydrogenase kinase 4	JNK	27273(Tax:10090)	26419(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inflammation increases pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- expression via the Jun N-Terminal Kinase -LRB- JNK -RRB- pathway in C2C12 cells .
16757381	0	pyruvate_dehydrogenase_kinase_4	87,118	PDK4	120,124	pyruvate dehydrogenase kinase 4	PDK4	5166	5166	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Retinoic_acids and trichostatin_A -LRB- TSA -RRB- , a histone deacetylase inhibitor , induce human pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- gene expression .
21586575	0	pyruvate_dehydrogenase_kinase_4	14,45	PDK4	47,51	pyruvate dehydrogenase kinase 4	PDK4	89813(Tax:10116)	89813(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- by CCAAT/enhancer-binding _ protein_beta -LRB- C/EBPbeta -RRB- .
26740179	0	pyruvate_dehydrogenase_kinase_4	23,54	PDK4	56,60	pyruvate dehydrogenase kinase 4	PDK4	27273(Tax:10090)	27273(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inflammation increases pyruvate_dehydrogenase_kinase_4 -LRB- PDK4 -RRB- expression via the Jun N-Terminal Kinase -LRB- JNK -RRB- pathway in C2C12 cells .
17360981	0	pyruvate_dehydrogenase_kinase_4	33,64	prolactin	79,88	pyruvate dehydrogenase kinase 4	prolactin	27273(Tax:10090)	19109(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|nmod|END_ENTITY	The STAT5A-mediated induction of pyruvate_dehydrogenase_kinase_4 expression by prolactin or growth_hormone in adipocytes .
23297365	0	pyruvate_dehydrogenase_kinase_isoenzyme_3	100,141	PDK3	143,147	pyruvate dehydrogenase kinase isoenzyme 3	PDK3	5165	5165	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new locus for X-linked dominant Charcot-Marie-Tooth_disease -LRB- CMTX6 -RRB- is caused by mutations in the pyruvate_dehydrogenase_kinase_isoenzyme_3 -LRB- PDK3 -RRB- gene .
9209064	0	pyruvate_kinase	103,118	Mck1	0,4	pyruvate kinase	Mck1	851193(Tax:4932)	855409(Tax:4932)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Mck1 , a member of the glycogen synthase kinase 3 family of protein kinases , is a negative regulator of pyruvate_kinase in the yeast Saccharomyces_cerevisiae .
24658033	0	pyruvate_kinase_M2	21,39	HSP40	0,5	pyruvate kinase M2	HSP40	5315	171221	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	HSP40 interacts with pyruvate_kinase_M2 and regulates glycolysis and cell proliferation in tumor cells .
20962042	0	pyruvate_kinase_M2	31,49	Prolactin	0,9	pyruvate kinase M2	Prolactin	5315	5617	Gene	Gene	activity|nmod|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	Prolactin inhibits activity of pyruvate_kinase_M2 to stimulate cell proliferation .
23640882	0	pyruvate_kinase_M2	42,60	Protein_tyrosine_phosphatase_1B	0,31	pyruvate kinase M2	Protein tyrosine phosphatase 1B	5315	5770	Gene	Gene	phosphorylation|amod|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Protein_tyrosine_phosphatase_1B regulates pyruvate_kinase_M2 tyrosine phosphorylation .
25784116	0	pyruvate_kinase_M2	19,37	fibroblast_growth_factor_receptor_1	69,104	pyruvate kinase M2	fibroblast growth factor receptor 1	5315	2260	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of pyruvate_kinase_M2 and lactate_dehydrogenase_a by fibroblast_growth_factor_receptor_1 in benign and malignant thyroid tissue .
25880801	0	pyruvate_kinase_M2	19,37	fibroblast_growth_factor_receptor_1	69,104	pyruvate kinase M2	fibroblast growth factor receptor 1	5315	2260	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of pyruvate_kinase_M2 and lactate_dehydrogenase_A by fibroblast_growth_factor_receptor_1 in benign and malignant thyroid tissue .
25880801	0	pyruvate_kinase_M2	19,37	fibroblast_growth_factor_receptor_1	69,104	pyruvate kinase M2	fibroblast growth factor receptor 1	5315	2260	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of pyruvate_kinase_M2 and lactate_dehydrogenase_A by fibroblast_growth_factor_receptor_1 in benign and malignant thyroid tissue .
22574221	0	pyruvate_kinase_M2	63,81	mammalian_target_of_rapamycin	100,129	pyruvate kinase M2	mammalian target of rapamycin	5315	2475	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Resveratrol inhibits cancer cell metabolism by down regulating pyruvate_kinase_M2 via inhibition of mammalian_target_of_rapamycin .
25263439	0	pyruvate_kinase_isoform_M2	22,48	TRIM35	0,6	pyruvate kinase isoform M2	TRIM35	5315	23087	Gene	Gene	Interacts|nmod|START_ENTITY Interacts|compound|END_ENTITY	TRIM35 Interacts with pyruvate_kinase_isoform_M2 to suppress the Warburg effect and tumorigenicity in hepatocellular_carcinoma .
6208068	0	quaking	40,47	Myelin_basic_protein	0,20	quaking	Myelin basic protein	19317(Tax:10090)	17196(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Myelin_basic_protein gene expression in quaking , jimpy , and myelin_synthesis-deficient mice .
1717701	0	quaking	69,76	myelin_basic_protein	24,44	quaking	myelin basic protein	19317(Tax:10090)	17196(Tax:10090)	Gene	Gene	oligodendrocytes|amod|START_ENTITY distribution|nmod|oligodendrocytes distribution|nmod|mRNA mRNA|compound|END_ENTITY	Spatial distribution of myelin_basic_protein mRNA and polypeptide in quaking oligodendrocytes in culture .
6170761	0	quaking	79,86	myelin_basic_protein	25,45	quaking	myelin basic protein	19317(Tax:10090)	17196(Tax:10090)	Gene	Gene	system|nmod|START_ENTITY distribution|nmod|system distribution|nmod|END_ENTITY	Regional distribution of myelin_basic_protein in the central nervous system of quaking , jimpy , and normal mice during development and aging .
9878249	0	quiescin_Q6	4,15	QSCN6	22,27	quiescin Q6	QSCN6	5768	5768	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The quiescin_Q6 gene -LRB- QSCN6 -RRB- is a fusion of two ancient gene families : thioredoxin and ERV1 .
17868694	0	quinolinate_phosphoribosyltransferase	43,80	hQPRTase	82,90	quinolinate phosphoribosyltransferase	hQPRTase	23475	23475	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Structural and kinetic characterization of quinolinate_phosphoribosyltransferase -LRB- hQPRTase -RRB- from homo_sapiens .
24793335	0	quinone_reductase	13,30	QR	32,34	quinone reductase	QR	12972(Tax:10090)	12972(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of quinone_reductase -LRB- QR -RRB- by withanolides isolated from Physalis angulata L. var .
10913150	0	quinone_reductase_2	56,75	MT3	45,48	quinone reductase 2	MT3	4835	4504	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the melatonin-binding site MT3 as the quinone_reductase_2 .
8921402	0	rBAT	48,52	SLC3A1	59,65	rBAT	SLC3A1	29725(Tax:10116)	6519	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure and organization of the human rBAT gene -LRB- SLC3A1 -RRB- .
12615066	0	rBSPRY	28,34	zetin_1	20,27	rBSPRY	zetin 1	64027(Tax:10116)	64027(Tax:10116)	Gene	Gene	START_ENTITY|dep|Characterization Characterization|nmod|END_ENTITY	Characterization of zetin_1 / rBSPRY , a novel binding partner of 14-3-3 proteins .
2295841	0	rCD4	36,40	CD4	31,34	rCD4	CD4	24932(Tax:10116)	24932(Tax:10116)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of recombinant soluble CD4 -LRB- rCD4 -RRB- on HIV-1_infection of monocyte/macrophages .
15778849	0	rCx39	35,40	connexin_39	22,33	rCx39	connexin 39	266707(Tax:10116)	266707(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Expression of the rat connexin_39 -LRB- rCx39 -RRB- gene in myoblasts and myotubes in developing and regenerating skeletal muscles : an in situ hybridization study .
15207918	0	rEAAC1	45,51	glutamate_transporter	23,44	rEAAC1	glutamate transporter	25550(Tax:10116)	29483(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dobj|expression	Modulation of neuronal glutamate_transporter rEAAC1 mRNA expression in rat brain by amitriptyline .
12145338	0	rFSHbeta	48,56	FSHbeta	39,46	rFSHbeta	FSHbeta	25447(Tax:10116)	25447(Tax:10116)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Pituitary homeobox 1 activates the rat FSHbeta -LRB- rFSHbeta -RRB- gene through both direct and indirect interactions with the rFSHbeta gene promoter .
1282572	0	rG-CSF	83,89	granulocyte_colony-stimulating_factor	44,81	rG-CSF	granulocyte colony-stimulating factor	25610(Tax:10116)	1440	Gene	Gene	significance|dep|START_ENTITY significance|nmod|END_ENTITY	-LSB- Clinical significance of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- in the chemotherapy of patients with malignant_lymphoma -RSB- .
1693062	0	rG-CSF	68,74	granulocyte_colony-stimulating_factor	29,66	rG-CSF	granulocyte colony-stimulating factor	25610(Tax:10116)	1440	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on chemotherapy-induced neutropenia in patients with lung_cancer -RSB- .
1704477	0	rG-CSF	78,84	granulocyte_colony-stimulating_factor	39,76	rG-CSF	granulocyte colony-stimulating factor	25610(Tax:10116)	1440	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	Protective effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- against various microbial infections in neutropenic mice .
1705488	0	rG-CSF	61,67	granulocyte_colony-stimulating_factor	22,59	rG-CSF	granulocyte colony-stimulating factor	25610(Tax:10116)	1440	Gene	Gene	Effect|dep|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on chemotherapy-induced neutropenia in patients with urogenital_cancer .
1717812	0	rG-CSF	91,97	granulocyte_colony-stimulating_factor	52,89	rG-CSF	granulocyte colony-stimulating factor	25610(Tax:10116)	1440	Gene	Gene	Mechanism|dep|START_ENTITY Mechanism|nmod|effect effect|nmod|END_ENTITY	Mechanism of protective effect of recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on Pseudomonas_infection .
2450817	0	rG-CSF	84,90	granulocyte_colony-stimulating_factor	45,82	rG-CSF	granulocyte colony-stimulating factor	25610(Tax:10116)	1440	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	Proliferative effects of a recombinant human granulocyte_colony-stimulating_factor -LRB- rG-CSF -RRB- on highly enriched hematopoietic progenitor cells .
9106172	0	rGM-CSF	64,71	granulocyte-macrophage_colony_stimulating_factor	14,62	rGM-CSF	granulocyte-macrophage colony stimulating factor	116630(Tax:10116)	1437	Gene	Gene	effect|dep|START_ENTITY effect|nmod|END_ENTITY	The effect of granulocyte-macrophage_colony_stimulating_factor -LRB- rGM-CSF -RRB- on macrophage function in microbial_disease .
9817598	0	rHOX	33,37	bone_morphogenetic_protein_2	135,163	rHOX	bone morphogenetic protein 2	266813(Tax:10116)	12156(Tax:10090)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|protein protein|amod|END_ENTITY	Expression of rat homeobox gene , rHOX , in developing and adult tissues in mice and regulation of its mRNA expression in osteoblasts by bone_morphogenetic_protein_2 and parathyroid hormone-related protein .
16315640	0	rHSP60	35,41	CD4	0,3	rHSP60	CD4	63868(Tax:10116)	920	Gene	Gene	T|nmod|START_ENTITY T|nsubj|END_ENTITY	CD4 and CD8 T cell response to the rHSP60 from Klebsiella_pneumoniae in peripheral blood mononuclear cells from patients with ankylosing_spondylitis .
1530794	0	rIFN-gamma	33,43	IFN-gamma	22,31	rIFN-gamma	IFN-gamma	25712(Tax:10116)	3458	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of recombinant IFN-gamma -LRB- rIFN-gamma -RRB- on the mechanism of human macrophage IgG FcRI-mediated cytotoxicity .
1373347	0	rIGF-I	80,86	IGF_binding_protein_3	0,21	rIGF-I	IGF binding protein 3	24482(Tax:10116)	3486	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|dep|effect	IGF_binding_protein_3 in patients with Laron_type_dwarfism : effect of exogenous rIGF-I .
8573611	0	rIL-2	16,21	CD4	31,34	rIL-2	CD4	116562(Tax:10116)	920	Gene	Gene	+|amod|START_ENTITY +|compound|END_ENTITY	Transduction of rIL-2 expanded CD4 + and CD8 + ovarian TIL-derived T cell lines with the G1Na -LRB- neor -RRB- replication-deficient retroviral vector .
18208763	0	rIL-2	39,44	interleukin-2	24,37	rIL-2	interleukin-2	116562(Tax:10116)	3558	Gene	Gene	Efficacy|dep|START_ENTITY Efficacy|nmod|END_ENTITY	Efficacy of recombinant interleukin-2 -LRB- rIL-2 -RRB- in patients with advanced_HIV-1_infection and blunted immune response to HAART .
2122928	0	rIL-2	75,80	interleukin-2	31,44	rIL-2	interleukin-2	116562(Tax:10116)	3558	Gene	Gene	activation|nmod|START_ENTITY trial|dep|activation trial|nmod|END_ENTITY	Phase I trial with recombinant interleukin-2 -LRB- rIL-2 -RRB- : immune activation by rIL-2 alone or following pretreatment with recombinant interferon-gamma .
2402104	0	rIL-2	53,58	interleukin-2	38,51	rIL-2	interleukin-2	116562(Tax:10116)	3558	Gene	Gene	Study|dep|START_ENTITY Study|nmod|cytotoxicity cytotoxicity|nmod|END_ENTITY	-LSB- Study of cytotoxicity of recombinant interleukin-2 -LRB- rIL-2 -RRB- expanded tumor infiltrating lymphocytes -LRB- TIL -RRB- in renal_cell_cancer -RSB- .
7820116	0	rIL-2	159,164	interleukin-2	54,67	rIL-2	interleukin-2	116562(Tax:10116)	16183(Tax:10090)	Gene	Gene	antibody|nmod|START_ENTITY monoclonal|dobj|antibody monoclonal|nsubj|Enhancement Enhancement|nmod|activity activity|nmod|END_ENTITY	Enhancement of the anti-tumor activity of recombinant interleukin-2 -LRB- rIL-2 -RRB- by immunocomplexing with an F -LRB- ab ' -RRB- 2 fragment of murine monoclonal antibody against rIL-2 .
7820116	0	rIL-2	69,74	interleukin-2	54,67	rIL-2	interleukin-2	116562(Tax:10116)	16183(Tax:10090)	Gene	Gene	Enhancement|dep|START_ENTITY Enhancement|nmod|activity activity|nmod|END_ENTITY	Enhancement of the anti-tumor activity of recombinant interleukin-2 -LRB- rIL-2 -RRB- by immunocomplexing with an F -LRB- ab ' -RRB- 2 fragment of murine monoclonal antibody against rIL-2 .
8280492	0	rIL-2	84,89	interleukin-2	30,43	rIL-2	interleukin-2	116562(Tax:10116)	3558	Gene	Gene	muteins|amod|START_ENTITY study|nmod|muteins Reconstitution|dep|study Reconstitution|nmod|END_ENTITY	Reconstitution of recombinant interleukin-2 -LRB- rIL-2 -RRB- : a comparative study of various rIL-2 muteins .
8292462	0	rIL-2	127,132	interleukin-2	50,63	rIL-2	interleukin-2	116562(Tax:10116)	16183(Tax:10090)	Gene	Gene	antibody|nmod|START_ENTITY immunocomplexing|nmod|antibody Enhancement|advcl|immunocomplexing Enhancement|nmod|activity activity|nmod|END_ENTITY	Enhancement of anti-tumor activity of recombinant interleukin-2 -LRB- rIL-2 -RRB- by immunocomplexing with a monoclonal antibody against rIL-2 .
9038610	0	rIL-2	52,57	interleukin-2	37,50	rIL-2	interleukin-2	116562(Tax:10116)	3558	Gene	Gene	effects|dep|START_ENTITY effects|nmod|END_ENTITY	The cognitive effects of recombinant interleukin-2 -LRB- rIL-2 -RRB- therapy : a controlled clinical trial using computerised assessments .
9414409	0	rIL-2	122,127	interleukin-2	50,63	rIL-2	interleukin-2	116562(Tax:10116)	16183(Tax:10090)	Gene	Gene	administration|amod|START_ENTITY time|nmod|administration dependent|nmod|time dependent|nsubj|success success|nmod|therapy therapy|compound|END_ENTITY	The success of locoregional , low-dose recombinant interleukin-2 therapy in tumor-bearing mice is dependent on the time of rIL-2 administration .
2467489	0	rIL-2	76,81	interleukin_2	61,74	rIL-2	interleukin 2	116562(Tax:10116)	3558	Gene	Gene	treated|dep|START_ENTITY treated|nmod|END_ENTITY	A case of cutaneous_T_cell_lymphoma treated with recombinant interleukin_2 -LRB- rIL-2 -RRB- .
2788945	0	rIL-2	69,74	interleukin_2	54,67	rIL-2	interleukin 2	116562(Tax:10116)	3558	Gene	Gene	cells|dep|START_ENTITY cells|amod|END_ENTITY	A phase II study of the administration of recombinant interleukin_2 -LRB- rIL-2 -RRB- plus lymphokine activated killer -LRB- LAK -RRB- cells in stage IV melanoma patients .
3100633	0	rIL_2	73,78	interleukin_2	58,71	rIL 2	interleukin 2	116562(Tax:10116)	3558	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Phenotypic and functional characterization of recombinant interleukin_2 -LRB- rIL_2 -RRB- - induced activated killer cells : analysis at the population and clonal levels .
10940388	0	rNUDE	129,134	LIS1	22,26	rNUDE	LIS1	83836(Tax:10116)	5048	Gene	Gene	START_ENTITY|nsubj|association association|nmod|END_ENTITY	Direct association of LIS1 , the lissencephaly gene product , with a mammalian homologue of a fungal nuclear distribution protein , rNUDE .
16325760	0	rOAT1	62,67	organic_anion_transporter_1	33,60	rOAT1	organic anion transporter 1	29509(Tax:10116)	29509(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Functional expression of the rat organic_anion_transporter_1 -LRB- rOAT1 -RRB- in Saccharomyces_cerevisiae .
11961115	0	rOat3	79,84	organic_anion_transporter_3	50,77	rOat3	organic anion transporter 3	83500(Tax:10116)	83500(Tax:10116)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Expression and functional characterization of rat organic_anion_transporter_3 -LRB- rOat3 -RRB- in the choroid_plexus .
18230276	0	rOct2	60,65	organic_cation_transporter_2	30,58	rOct2	organic cation transporter 2	29503(Tax:10116)	29503(Tax:10116)	Gene	Gene	involvement|appos|START_ENTITY involvement|nmod|END_ENTITY	Functional involvement of the organic_cation_transporter_2 -LRB- rOct2 -RRB- in the renal uptake of organic cations in rats .
11237868	0	rPICK1	88,94	TIS21	19,24	rPICK1	TIS21	84591(Tax:10116)	12227(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|protein protein|compound|END_ENTITY	Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1 .
6507005	0	rT3	19,22	T3	15,17	rT3	T3	24754(Tax:10116)	24754(Tax:10116)	Gene	Gene	T4|appos|START_ENTITY T4|appos|END_ENTITY	Serum free T4 , T3 , rT3 , 3,3 ' - diiodothyronine and 3 ' ,5 ' - diiodothyronine measured by ultrafiltration .
11242177	0	rTBP-1	59,65	TNF-alpha	32,41	rTBP-1	TNF-alpha	29677(Tax:10116)	7124	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	In vitro effects of recombinant TNF-alpha binding protein -LRB- rTBP-1 -RRB- on hematopoiesis of HIV-infected patients .
3216223	0	rTNF	81,85	TNF	0,3	rTNF	TNF	24835(Tax:10116)	7124	Gene	Gene	combination|nmod|START_ENTITY TNF|nmod|combination induces|dep|TNF induces|nsubj|END_ENTITY	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
3216223	0	rTNF	81,85	TNF	111,114	rTNF	TNF	24835(Tax:10116)	21926(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY TNF|nmod|combination TNF|nmod|END_ENTITY	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
3216223	0	rTNF	81,85	TNF	23,26	rTNF	TNF	24835(Tax:10116)	7124	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	TNF induces endogenous TNF in vivo : the basis of EET therapy as a combination of rTNF together with endogenous TNF .
1561804	0	rTNF_alpha	65,75	interferon-gamma	96,112	rTNF alpha	interferon-gamma	24835(Tax:10116)	3458	Gene	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	In transit metastases of malignant melanoma treated by high dose rTNF_alpha in combination with interferon-gamma and melphalan in isolation perfusion .
16804107	0	rZip10	76,82	Slc39a10	84,92	rZip10	Slc39a10	100008565(Tax:10116)	363229(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular cloning and functional characterization of novel zinc transporter rZip10 -LRB- Slc39a10 -RRB- involved in zinc uptake across rat renal brush-border membrane .
12656988	0	rab1	15,19	Golgin-84	0,9	rab1	Golgin-84	5861	9950	Gene	Gene	partner|amod|START_ENTITY partner|nsubj|END_ENTITY	Golgin-84 is a rab1 binding partner involved in Golgi structure .
15796781	0	rab1	81,85	Iporin	39,45	rab1	Iporin	5861	9853	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of Iporin as a novel interaction partner for rab1 .
8384302	0	rab3A	53,58	p25	59,62	rab3A	p25	282029(Tax:9913)	280968(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Rabphilin-3A , a putative target protein for smg_p25A / rab3A p25 small GTP-binding protein related to synaptotagmin .
8384302	0	rab3A	53,58	smg_p25A	44,52	rab3A	smg p25A	282029(Tax:9913)	282029(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Rabphilin-3A , a putative target protein for smg_p25A / rab3A p25 small GTP-binding protein related to synaptotagmin .
15207266	0	rab3a	43,48	alpha-synuclein	9,24	rab3a	alpha-synuclein	5864	6622	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse_Lewy_body_disease .
14636058	0	rabaptin-5	50,60	GGA1	29,33	rabaptin-5	GGA1	9135	26088	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The interaction of the human GGA1 GAT domain with rabaptin-5 is mediated by residues on its three-helix bundle .
10608812	0	rabaptin-5	6,16	caspase-3	43,52	rabaptin-5	caspase-3	9135	836	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|advcl|END_ENTITY	Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis .
8292018	0	rabphilin-3A	16,28	Rab3A	60,65	rabphilin-3A	Rab3A	171039(Tax:10116)	25531(Tax:10116)	Gene	Gene	START_ENTITY|appos|protein protein|nmod|END_ENTITY	Localization of rabphilin-3A , a putative target protein for Rab3A , at the sites of Ca -LRB- 2 + -RRB- - dependent exocytosis in PC12 cells .
8943213	0	rabphilin-3A	39,51	alpha-actinin	57,70	rabphilin-3A	alpha-actinin	22895	87	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of rabphilin-3A with alpha-actinin .
15572663	0	rac1	14,18	Brk	0,3	rac1	Brk	5879	5753	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin .
20004474	0	rac1	35,39	Transglutaminase_II	0,19	rac1	Transglutaminase II	363875(Tax:10116)	56083(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transglutaminase_II interacts with rac1 , regulates production of reactive oxygen species , expression of snail , secretion of Th2 cytokines and mediates in vitro and in vivo_allergic_inflammation .
10232579	0	rad17	75,80	HRad17	0,6	rad17	HRad17	5884	5884	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	HRad17 , a human homologue of the Schizosaccharomyces_pombe checkpoint gene rad17 , is overexpressed in colon_carcinoma .
8846774	0	rad17	14,19	RAD24	50,55	rad17	RAD24	854550(Tax:4932)	856920(Tax:4932)	Gene	Gene	START_ENTITY|dep|homologue homologue|nmod|END_ENTITY	Fission_yeast rad17 : a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins .
11243849	0	rad21	6,11	hHR21	18,23	rad21	hHR21	5885	5885	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Human rad21 gene , hHR21 -LRB- SP -RRB- , is downregulated by hypoxia in human tumor cells .
20109539	0	radixin	20,27	ezrin	14,19	radixin	ezrin	5962	7430	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream .
22012890	0	radixin	34,41	ezrin	27,32	radixin	ezrin	5962	7430	Gene	Gene	domain|dep|START_ENTITY domain|dep|END_ENTITY	Unfurling of the band_4 .1 , ezrin , radixin , moesin -LRB- FERM -RRB- domain of the merlin tumor suppressor .
22089331	0	radixin	21,28	miR-31	6,12	radixin	miR-31	5962	407035	Gene	Gene	START_ENTITY|nsubj|targets targets|amod|END_ENTITY	Human miR-31 targets radixin and inhibits migration and invasion of glioma cells .
20109539	0	radixin	20,27	moesin	28,34	radixin	moesin	5962	4478	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream .
16757329	0	raf	43,46	Raf_kinase_inhibitor_protein	0,28	raf	Raf kinase inhibitor protein	22882	5037	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Raf_kinase_inhibitor_protein regulation of raf and MAPK signaling .
9261098	0	raf-1	33,38	14-3-3_zeta	0,11	raf-1	14-3-3 zeta	5894	7534	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	14-3-3_zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain .
9312114	0	raf-1	10,15	HMGI-C	88,94	raf-1	HMGI-C	5894	8091	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Oncogenic raf-1 induces the expression of non-histone chromosomal architectural protein HMGI-C via a p44/p42 mitogen-activated protein kinase-dependent pathway in salivary epithelial cells .
1639773	0	raf-1	79,84	Interleukin-2	0,13	raf-1	Interleukin-2	5894	3558	Gene	Gene	translocation|nmod|START_ENTITY induces|dobj|translocation induces|nsubj|END_ENTITY	Interleukin-2 -LRB- IL-2 -RRB- induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2_receptor into the cytosol .
21331358	0	rag-2	92,97	jak3	98,102	rag-2	jak3	5897	3718	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2 / jak3 double-deficient mice .
9271224	0	ragged	175,181	Ra	183,185	ragged	Ra	20672(Tax:10090)	20672(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Tissue-specific expression of the human laminin_alpha5-chain , and mapping of the gene to human chromosome 20q13.2-13 .3 and to distal mouse chromosome 2 near the locus for the ragged -LRB- Ra -RRB- mutation .
9735344	0	ragged	49,55	Ra	57,59	ragged	Ra	20672(Tax:10090)	20672(Tax:10090)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Evaluation of Lama5 as a candidate for the mouse ragged -LRB- Ra -RRB- mutation .
12892706	0	rap	6,9	Rap1	11,15	rap	Rap1	4043	5906	Gene	Gene	START_ENTITY|dep|signaling signaling|compound|END_ENTITY	A bad rap : Rap1 signaling and oncogenesis .
3045729	0	rap1	12,16	Dras3	60,65	rap1	Dras3	38244(Tax:7227)	38244(Tax:7227)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the ` effector ' region .
7539769	0	rap1B	40,45	SIN-1	49,54	rap1B	SIN-1	5908	79109	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Synergistic phosphorylation of platelet rap1B by SIN-1 and iloprost .
8812503	0	rapsyn	31,37	RAPSN	57,62	rapsyn	RAPSN	5913	5913	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Cloning of cDNA encoding human rapsyn and mapping of the RAPSN gene locus to chromosome 11p11.2-p11 .1 .
15282317	0	rapsyn	18,24	kaiso	37,42	rapsyn	kaiso	19400(Tax:10090)	56805(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY Regulation|nmod|promoter Regulation|nmod|END_ENTITY	Regulation of the rapsyn promoter by kaiso and delta-catenin .
26344902	0	raptor	83,89	AMPK	40,44	raptor	AMPK	57521	5563	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells : Reversal by oleate is similar to metformin .
26344902	0	raptor	83,89	AMPK	40,44	raptor	AMPK	57521	5563	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells : Reversal by oleate is similar to metformin .
12150925	0	raptor	20,26	mTOR	0,4	raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery .
12604610	0	raptor	50,56	mTOR	35,39	raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	partner|appos|START_ENTITY partner|appos|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
12604610	0	raptor	50,56	mTOR	68,72	raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	partner|appos|START_ENTITY binds|nsubj|partner binds|ccomp|substrates substrates|nsubj|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
15066126	0	raptor	16,22	mTOR	83,87	raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	Dissociation|nmod|START_ENTITY mechanism|nsubj|Dissociation mechanism|nmod|inhibition inhibition|nmod|function function|compound|END_ENTITY	Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function .
16824195	0	raptor	114,120	mTOR	144,148	raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY 4E-BP1|nmod|association 4E-BP1|nmod|END_ENTITY	Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size .
19346248	0	raptor	96,102	mTOR	106,110	raptor	mTOR	57521	21977(Tax:10090)	Gene	Gene	phosphorylation|nmod|START_ENTITY associated|nmod|phosphorylation associated|nmod|END_ENTITY	Mammalian_target_of_rapamycin complex 1 -LRB- mTORC1 -RRB- activity is associated with phosphorylation of raptor by mTOR .
23440873	0	raptor	57,63	mTOR	32,36	raptor	mTOR	74370(Tax:10090)	21977(Tax:10090)	Gene	Gene	Distribution|appos|START_ENTITY Distribution|nmod|END_ENTITY	Distribution and association of mTOR with its cofactors , raptor and rictor , in cumulus cells and oocytes during meiotic maturation in mice .
12604610	0	raptor	50,56	mammalian_target_of_rapamycin	4,33	raptor	mammalian target of rapamycin	57521	2475	Gene	Gene	partner|appos|START_ENTITY partner|compound|END_ENTITY	The mammalian_target_of_rapamycin -LRB- mTOR -RRB- partner , raptor , binds the mTOR substrates p70_S6_kinase and 4E-BP1 through their TOR_signaling -LRB- TOS -RRB- motif .
16455309	0	raraa	53,58	rarab	60,65	raraa	rarab	30680(Tax:7955)	555364(Tax:7955)	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|nsubj|Characterization	Characterization of the retinoic_acid receptor genes raraa , rarab and rarg during zebrafish development .
16455309	0	rarab	60,65	raraa	53,58	rarab	raraa	555364(Tax:7955)	30680(Tax:7955)	Gene	Gene	START_ENTITY|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of the retinoic_acid receptor genes raraa , rarab and rarg during zebrafish development .
8420353	0	ras	14,17	p21	27,30	ras	p21	3265	644914	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues : correlation with histopathologic features and receptors for estrogen , progesterone , and epidermal growth factor .
9689648	0	rasGAP	62,68	rasGTPase_activating_protein	32,60	rasGAP	rasGTPase activating protein	5921	5921	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Immunohistochemical analysis of rasGTPase_activating_protein -LRB- rasGAP -RRB- in prostate_cancer .
9689648	0	rasGTPase_activating_protein	32,60	rasGAP	62,68	rasGTPase activating protein	rasGAP	5921	5921	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Immunohistochemical analysis of rasGTPase_activating_protein -LRB- rasGAP -RRB- in prostate_cancer .
11279364	0	ras_guanyl_releasing_protein	16,44	RasGRP	46,52	ras guanyl releasing protein	RasGRP	29434(Tax:10116)	29434(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Distribution of ras_guanyl_releasing_protein -LRB- RasGRP -RRB- mRNA in the adult rat central nervous system .
8759895	0	rb1	25,28	retinoblastoma	4,18	rb1	retinoblastoma	5925	5925	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The retinoblastoma gene -LRB- rb1 -RRB- in acute_myeloid_leukaemia : analysis of gene rearrangements , protein expression and comparison of disease outcome .
19731076	0	rbp1	103,107	Bmrbp1	45,51	rbp1	Bmrbp1	41294(Tax:7227)	733053(Tax:7091)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and expression analysis of Bmrbp1 , the Bombyx_mori homologue of the Drosophila gene rbp1 .
10645722	0	rca	29,32	Rubisco_activase	0,16	rca	Rubisco activase	5717936(Tax:3055)	5717936(Tax:3055)	Gene	Gene	transcript|appos|START_ENTITY transcript|amod|END_ENTITY	Rubisco_activase transcript -LRB- rca -RRB- abundance increases when the marine unicellular green alga Chlorococcum littorale is grown under high-CO2 stress .
9000053	0	rca1	48,52	Cyclin_A	63,71	rca1	Cyclin A	33959(Tax:7227)	39340(Tax:7227)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	Control of G1 in the developing Drosophila eye : rca1 regulates Cyclin_A .
20238051	0	rd1	71,74	Pde6b	63,68	rd1	Pde6b	18587(Tax:10090)	18587(Tax:10090)	Gene	Gene	mouse|appos|START_ENTITY mouse|amod|END_ENTITY	Do calcium channel blockers rescue dying photoreceptors in the Pde6b -LRB- rd1 -RRB- mouse ?
9477305	0	rd5	16,19	tub	11,14	rd5	tub	22141(Tax:10090)	22141(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	The murine tub -LRB- rd5 -RRB- mutation is not associated with a primary axonemal_defect .
7914867	0	rdgB	169,173	retinal_degeneration_B	140,162	rdgB	retinal degeneration B	32340(Tax:7227)	32340(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Localization of the gene encoding human phosphatidylinositol transfer protein -LRB- PITPN -RRB- to 17p13 .3 : a gene showing homology to the Drosophila retinal_degeneration_B gene -LRB- rdgB -RRB- .
17270348	0	rdh9	12,16	Crad3	18,23	rdh9	Crad3	103142(Tax:10090)	103142(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ontogeny of rdh9 -LRB- Crad3 -RRB- expression : ablation causes changes in retinoid and steroid metabolizing enzymes , but RXR and androgen signaling seem normal .
8112464	0	rds	64,67	retinal_degeneration_slow	37,62	rds	retinal degeneration slow	19133(Tax:10090)	19133(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|mRNA mRNA|nmod|END_ENTITY	Diurnal expression of NGF1-A mRNA in retinal_degeneration_slow -LRB- rds -RRB- mutant mouse retina .
25824963	0	reactive_oxygen_species_modulator_1	21,56	Romo-1	58,64	reactive oxygen species modulator 1	Romo-1	140823	140823	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The rs6060566 of the reactive_oxygen_species_modulator_1 -LRB- Romo-1 -RRB- gene affects Romo-1 expression and the development of diabetic_retinopathy in Caucasians with type 2 diabetes .
3755133	0	recA	12,16	recA	42,46	recA	recA	5888	5888	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Exchange of recA protein between adjacent recA protein-single-stranded DNA complexes .
3755133	0	recA	42,46	recA	12,16	recA	recA	5888	5888	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Exchange of recA protein between adjacent recA protein-single-stranded DNA complexes .
10092526	0	rec_A	109,114	RAD51	115,120	rec A	RAD51	19361(Tax:10090)	19361(Tax:10090)	Gene	Gene	family|compound|START_ENTITY family|compound|END_ENTITY	Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene , a member of the rec_A / RAD51 gene family .
9023342	0	receptor	43,51	P2Y2	27,31	receptor	P2Y2	18436(Tax:10090)	18442(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Transient up-regulation of P2Y2 nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes .
18042005	0	receptor	40,48	neurokinin-1	27,39	receptor	neurokinin-1	6869	6863	Gene	Gene	antagonist|compound|START_ENTITY antagonist|amod|END_ENTITY	Fosaprepitant -LRB- MK-0517 -RRB- : a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea_and_vomiting .
11579214	0	receptor-associated_protein	39,66	RAP	113,116	receptor-associated protein	RAP	116565(Tax:10116)	116565(Tax:10116)	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Binding of the low density lipoprotein receptor-associated_protein -LRB- RAP -RRB- to thyroglobulin -LRB- Tg -RRB- : putative role of RAP in the Tg secretory pathway .
12801688	0	receptor-associated_protein	15,42	RAP	44,47	receptor-associated protein	RAP	4043	4043	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Mapping of the receptor-associated_protein -LRB- RAP -RRB- binding proteins on living fibroblast cells using an atomic force microscope .
15383619	0	receptor-associated_protein	22,49	RAP	51,54	receptor-associated protein	RAP	16976(Tax:10090)	16976(Tax:10090)	Gene	Gene	transfer|nmod|START_ENTITY transfer|appos|END_ENTITY	Efficient transfer of receptor-associated_protein -LRB- RAP -RRB- across the blood-brain barrier .
16260783	0	receptor-interacting_protein	89,117	TAK1	0,4	receptor-interacting protein	TAK1	8737	6885	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	TAK1 is recruited to the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- _ receptor_1 complex in a receptor-interacting_protein -LRB- RIP -RRB- - dependent manner and cooperates with MEKK3 leading to NF-kappaB activation .
19780716	0	receptor-interacting_protein_140	55,87	RIP140	89,95	receptor-interacting protein 140	RIP140	268903(Tax:10090)	268903(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	MicroRNA mir-346 targets the 5 ' - untranslated region of receptor-interacting_protein_140 -LRB- RIP140 -RRB- mRNA and up-regulates its protein expression .
21504789	0	receptor-interacting_protein_140	12,44	perilipin	69,78	receptor-interacting protein 140	perilipin	8204	5346	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cytoplasmic receptor-interacting_protein_140 -LRB- RIP140 -RRB- interacts with perilipin to regulate lipolysis .
26170965	0	receptor-interacting_protein_4	28,58	interleukin-17	10,24	receptor-interacting protein 4	interleukin-17	54101	3605	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of interleukin-17 on receptor-interacting_protein_4 expression and keratinocyte proliferation .
22237751	0	receptor-interacting_protein_kinase_1	6,43	Rip1	0,4	receptor-interacting protein kinase 1	Rip1	19766(Tax:10090)	19766(Tax:10090)	Gene	Gene	mediates|dep|START_ENTITY mediates|amod|END_ENTITY	Rip1 -LRB- receptor-interacting_protein_kinase_1 -RRB- mediates necroptosis and contributes to renal_ischemia / reperfusion injury .
17031460	0	receptor-like_kinase	99,119	RLK	125,128	receptor-like kinase	RLK	836863(Tax:3702)	836863(Tax:3702)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Domain-specific positive selection contributes to the evolution of Arabidopsis leucine-rich repeat receptor-like_kinase -LRB- LRR RLK -RRB- genes .
16477135	0	receptor-like_kinase_gene	57,82	RLK	84,87	receptor-like kinase gene	RLK	100286391(Tax:4565)	100286391(Tax:4565)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Cloning , characterization and expression analysis of the receptor-like_kinase_gene -LRB- RLK -RRB- in common_wheat .
7681159	0	receptor-like_tyrosine_kinase	59,88	flk2	53,57	receptor-like tyrosine kinase	flk2	6259	2322	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the protein encoded by the flt3 -LRB- flk2 -RRB- receptor-like_tyrosine_kinase gene .
7681159	0	receptor-like_tyrosine_kinase	59,88	flt3	47,51	receptor-like tyrosine kinase	flt3	6259	2322	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Characterization of the protein encoded by the flt3 -LRB- flk2 -RRB- receptor-like_tyrosine_kinase gene .
7918100	0	receptor-protein_tyrosine_kinase	22,54	eck	61,64	receptor-protein tyrosine kinase	eck	14257(Tax:10090)	13836(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The expression of the receptor-protein_tyrosine_kinase gene , eck , is highly restricted during early mouse development .
22326262	0	receptor_activator_of_NF-kB_ligand	65,99	RANKL	101,106	receptor activator of NF-kB ligand	RANKL	8600	8600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- / S1P_receptor_1 signaling regulates receptor_activator_of_NF-kB_ligand -LRB- RANKL -RRB- expression in rheumatoid_arthritis .
22326262	0	receptor_activator_of_NF-kB_ligand	65,99	S1P_receptor_1	30,44	receptor activator of NF-kB ligand	S1P receptor 1	8600	1901	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sphingosine_1-phosphate -LRB- S1P -RRB- / S1P_receptor_1 signaling regulates receptor_activator_of_NF-kB_ligand -LRB- RANKL -RRB- expression in rheumatoid_arthritis .
17485464	0	receptor_activator_of_NF-kappaB_ligand	31,69	NF-kappaB_p50	0,13	receptor activator of NF-kappaB ligand	NF-kappaB p50	8600	4790	Gene	Gene	regulate|dobj|START_ENTITY regulate|nsubj|END_ENTITY	NF-kappaB_p50 and p52 regulate receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- and tumor_necrosis_factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1 .
17182555	0	receptor_activator_of_NF-kappaB_ligand	43,81	Osteoprotegerin	0,15	receptor activator of NF-kappaB ligand	Osteoprotegerin	21943(Tax:10090)	18383(Tax:10090)	Gene	Gene	level|nmod|START_ENTITY reduces|dobj|level reduces|nsubj|END_ENTITY	Osteoprotegerin reduces the serum level of receptor_activator_of_NF-kappaB_ligand derived from osteoblasts .
11920576	0	receptor_activator_of_NF-kappaB_ligand	33,71	RANKL	73,78	receptor activator of NF-kappaB ligand	RANKL	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of activation-induced receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- expression in T cells .
15205949	0	receptor_activator_of_NF-kappaB_ligand	14,52	RANKL	54,59	receptor activator of NF-kappaB ligand	RANKL	8600	8600	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- mRNA in human multiple_myeloma cells .
23295770	0	receptor_activator_of_NF-kappaB_ligand	85,123	RANKL	125,130	receptor activator of NF-kappaB ligand	RANKL	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	proliferation|amod|START_ENTITY proliferation|appos|END_ENTITY	Atorvastatin-induced increase in progenitor cell levels is rather caused by enhanced receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- cell proliferation than by bone marrow mobilization .
15544627	0	receptor_activator_of_NF-kappaB_ligand	24,62	osteoprotegerin	113,128	receptor activator of NF-kappaB ligand	osteoprotegerin	8600	4982	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Increased expression of receptor_activator_of_NF-kappaB_ligand -LRB- RANKL -RRB- , its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn 's _ disease patients .
12244151	0	receptor_activator_of_NF-kappa_B	49,81	RANK	83,87	receptor activator of NF-kappa B	RANK	21934(Tax:10090)	21934(Tax:10090)	Gene	Gene	interactions|amod|START_ENTITY interactions|appos|END_ENTITY	Regulation of mucosal dendritic cell function by receptor_activator_of_NF-kappa_B -LRB- RANK -RRB- / RANK ligand interactions : impact on tolerance induction .
10574572	0	receptor_activator_of_NF_kappa_B_ligand	23,62	RANKL	16,21	receptor activator of NF kappa B ligand	RANKL	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Localization Localization|nmod|END_ENTITY	Localization of RANKL -LRB- receptor_activator_of_NF_kappa_B_ligand -RRB- mRNA and protein in skeletal and extraskeletal tissues .
20857484	0	receptor_activator_of_NFkB	22,48	RANK	50,54	receptor activator of NFkB	RANK	8792	8792	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of receptor_activator_of_NFkB -LRB- RANK -RRB- in a series of primary solid_tumors and related bone metastases .
21533547	0	receptor_activator_of_nuclear_factor-kB_ligand	63,109	Hypoxia_inducible_factor-1a	0,27	receptor activator of nuclear factor-kB ligand	Hypoxia inducible factor-1a	8600	3091	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Hypoxia_inducible_factor-1a directly induces the expression of receptor_activator_of_nuclear_factor-kB_ligand in periodontal ligament fibroblasts .
25776619	0	receptor_activator_of_nuclear_factor-kappa-B_ligand	42,93	RANKL	95,100	receptor activator of nuclear factor-kappa-B ligand	RANKL	8600	8600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CCAAT/enhancer-binding protein b promotes receptor_activator_of_nuclear_factor-kappa-B_ligand -LRB- RANKL -RRB- expression and osteoclast formation in the synovium in rheumatoid_arthritis .
25811130	0	receptor_activator_of_nuclear_factor-kappa-B_ligand	42,93	RANKL	95,100	receptor activator of nuclear factor-kappa-B ligand	RANKL	8600	8600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CCAAT/enhancer-binding protein b promotes receptor_activator_of_nuclear_factor-kappa-B_ligand -LRB- RANKL -RRB- expression and osteoclast formation in the synovium in rheumatoid_arthritis .
13679377	0	receptor_activator_of_nuclear_factor-kappaB_ligand	23,73	RANKL	75,80	receptor activator of nuclear factor-kappaB ligand	RANKL	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	isoforms|amod|START_ENTITY isoforms|amod|END_ENTITY	Multimerization of the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- isoforms and regulation of osteoclastogenesis .
22768778	0	receptor_activator_of_nuclear_factor-kappaB_ligand	74,124	Toll-like_receptor_2	11,31	receptor activator of nuclear factor-kappaB ligand	Toll-like receptor 2	8600	7097	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of Toll-like_receptor_2 and Toll-like_receptor_4 on expression of receptor_activator_of_nuclear_factor-kappaB_ligand in human periodontal ligament fibroblasts induced by lipopolysaccharide -RSB- .
15068113	0	receptor_activator_of_nuclear_factor-kappaB_ligand	78,128	interleukin-1beta	22,39	receptor activator of nuclear factor-kappaB ligand	interleukin-1beta	8600	3553	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of interleukin-1beta and prostaglandin_E2 on expression of receptor_activator_of_nuclear_factor-kappaB_ligand in human periodontal ligament cells .
14675140	0	receptor_activator_of_nuclear_factor-kappaB_ligand	99,149	osteoprotegerin	206,221	receptor activator of nuclear factor-kappaB ligand	osteoprotegerin	8600	4982	Gene	Gene	osteoclast_differentiation_factor|dep|START_ENTITY END_ENTITY|nsubj|osteoclast_differentiation_factor	Expression of parathyroid_hormone-related_protein -LRB- PTHrP -RRB- , osteoclast_differentiation_factor -LRB- ODF -RRB- / receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- and osteoclastogenesis_inhibitory_factor -LRB- OCIF -RRB- / osteoprotegerin -LRB- OPG -RRB- in ameloblastomas .
17453373	0	receptor_activator_of_nuclear_factor-kappaB_ligand	63,113	osteoprotegerin	122,137	receptor activator of nuclear factor-kappaB ligand	osteoprotegerin	8600	4982	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Abnormal bone remodeling process is due to an imbalance in the receptor_activator_of_nuclear_factor-kappaB_ligand -LRB- RANKL -RRB- / osteoprotegerin -LRB- OPG -RRB- axis in patients with solid tumors metastatic to the skeleton .
15327520	0	receptor_activator_of_nuclear_factor-kappa_B_ligand	8,59	osteoprotegerin	69,84	receptor activator of nuclear factor-kappa B ligand	osteoprotegerin	8600	4982	Gene	Gene	1-alpha|amod|START_ENTITY 1-alpha|amod|END_ENTITY	Role of receptor_activator_of_nuclear_factor-kappa_B_ligand -LRB- RANKL -RRB- , osteoprotegerin and macrophage protein 1-alpha -LRB- MIP-1a -RRB- in monoclonal_gammopathy_of_undetermined_significance -LRB- MGUS -RRB- .
24693367	0	receptor_activator_of_nuclear_factor-kappa_B_ligand	61,112	osteoprotegerin	33,48	receptor activator of nuclear factor-kappa B ligand	osteoprotegerin	8600	4982	Gene	Gene	START_ENTITY|nsubj|Effect Effect|acl|breastfeeding breastfeeding|nmod|serum serum|amod|END_ENTITY	Effect of breastfeeding on serum osteoprotegerin and soluble receptor_activator_of_nuclear_factor-kappa_B_ligand in full term neonates .
26123746	0	receptor_activator_of_nuclear_factor_kB_ligand	54,100	BMP-2	123,128	receptor activator of nuclear factor kB ligand	Smad1	8600	4086	Gene	Gene	expression|amod|START_ENTITY expression|acl|induced induced|nmod|END_ENTITY	RNA interference-mediated knockdown of Smad1 inhibits receptor_activator_of_nuclear_factor_kB_ligand expression induced by BMP-2 in primary osteoblasts .
23360112	0	receptor_activator_of_nuclear_factor_kB_ligand	6,52	RANKL	54,59	receptor activator of nuclear factor kB ligand	RANKL	8600	8600	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum receptor_activator_of_nuclear_factor_kB_ligand -LRB- RANKL -RRB- levels predict biochemical recurrence in patients undergoing radical prostatectomy .
11870668	0	receptor_activator_of_nuclear_factor_kappa-B_ligand	29,80	RANK-L	82,88	receptor activator of nuclear factor kappa-B ligand	RANK-L	8600	8600	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunohistochemical study of receptor_activator_of_nuclear_factor_kappa-B_ligand -LRB- RANK-L -RRB- in human osteolytic bone_tumors .
21708014	0	receptor_activator_of_nuclear_factor_kappa-B_ligand	66,117	RANKL	119,124	receptor activator of nuclear factor kappa-B ligand	RANKL	8600	8600	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Potential role and mechanism of IFN-gamma inducible protein-10 on receptor_activator_of_nuclear_factor_kappa-B_ligand -LRB- RANKL -RRB- expression in rheumatoid_arthritis .
17549607	0	receptor_activator_of_nuclear_factor_kappaB_ligand	63,113	Macrophage_inflammatory_protein-1alpha	0,38	receptor activator of nuclear factor kappaB ligand	Macrophage inflammatory protein-1alpha	21943(Tax:10090)	20302(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Macrophage_inflammatory_protein-1alpha -LRB- MIP-1alpha -RRB- enhances a receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways .
17549607	0	receptor_activator_of_nuclear_factor_kappaB_ligand	63,113	RANKL	115,120	receptor activator of nuclear factor kappaB ligand	RANKL	21943(Tax:10090)	21943(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Macrophage_inflammatory_protein-1alpha -LRB- MIP-1alpha -RRB- enhances a receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathways .
18072013	0	receptor_activator_of_nuclear_factor_kappaB_ligand	16,66	RANKL	68,73	receptor activator of nuclear factor kappaB ligand	RANKL	8600	8600	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- in healthy women and men .
10693864	0	receptor_activator_of_nuclear_factor_kappaB_ligand	15,65	osteoclast_differentiation_factor	66,99	receptor activator of nuclear factor kappaB ligand	osteoclast differentiation factor	8600	8600	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of receptor_activator_of_nuclear_factor_kappaB_ligand / osteoclast_differentiation_factor in osteoclastogenesis from synoviocytes in rheumatoid_arthritis .
11393778	0	receptor_activator_of_nuclear_factor_kappaB_ligand	37,87	osteoprotegerin	91,106	receptor activator of nuclear factor kappaB ligand	osteoprotegerin	8600	4982	Gene	Gene	START_ENTITY|nmod|correlates correlates|compound|END_ENTITY	The ratio of messenger RNA levels of receptor_activator_of_nuclear_factor_kappaB_ligand to osteoprotegerin correlates with bone remodeling indices in normal human cancellous bone but not in osteoarthritis .
14741739	0	receptor_activator_of_nuclear_factor_kappaB_ligand	90,140	osteoprotegerin	43,58	receptor activator of nuclear factor kappaB ligand	osteoprotegerin	21943(Tax:10090)	18383(Tax:10090)	Gene	Gene	involvement|nmod|START_ENTITY activity|dep|involvement activity|acl|induced induced|nmod|END_ENTITY	Cellular activity and signaling induced by osteoprotegerin in osteoclasts : involvement of receptor_activator_of_nuclear_factor_kappaB_ligand and MAPK .
15930166	0	receptor_activator_of_nuclear_factor_kappaB_ligand	71,121	osteoprotegerin	122,137	receptor activator of nuclear factor kappaB ligand	osteoprotegerin	8600	4982	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Alpha-lipoic_acid suppresses osteoclastogenesis despite increasing the receptor_activator_of_nuclear_factor_kappaB_ligand / osteoprotegerin ratio in human bone marrow stromal cells .
16828054	0	receptor_activator_of_nuclear_factor_kappaB_ligand	126,176	osteoprotegerin	20,35	receptor activator of nuclear factor kappaB ligand	osteoprotegerin	8600	4982	Gene	Gene	interactions|nmod|START_ENTITY role|nmod|interactions resonance|dep|role binding|nmod|resonance binding|nsubj|Characterization Characterization|nmod|END_ENTITY	Characterization of osteoprotegerin binding to glycosaminoglycans by surface plasmon resonance : role in the interactions with receptor_activator_of_nuclear_factor_kappaB_ligand -LRB- RANKL -RRB- and RANK .
18166509	0	receptor_activator_of_nuclear_factor_kappaB_ligand	74,124	osteoprotegerin	125,140	receptor activator of nuclear factor kappaB ligand	osteoprotegerin	117516(Tax:10116)	25341(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY ratio|compound|END_ENTITY	Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor_activator_of_nuclear_factor_kappaB_ligand / osteoprotegerin ratio .
12490655	0	receptor_activator_of_nuclear_factor_kappa_B_ligand	47,98	IL-7	0,4	receptor activator of nuclear factor kappa B ligand	IL-7	21943(Tax:10090)	16196(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	IL-7 induces bone_loss in vivo by induction of receptor_activator_of_nuclear_factor_kappa_B_ligand and tumor_necrosis_factor_alpha from T cells .
17251392	0	receptor_activity-modifying_protein_2	21,58	endothelin-1	90,102	receptor activity-modifying protein 2	endothelin-1	10266	1906	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Hypoxic induction of receptor_activity-modifying_protein_2 alters regulation of pulmonary endothelin-1 by adrenomedullin : induction under normoxia versus inhibition under hypoxia .
16075364	0	receptor_activity_modifying_protein-3	28,65	Parathyroid_hormone	0,19	receptor activity modifying protein-3	Parathyroid hormone	56089(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Parathyroid_hormone induces receptor_activity_modifying_protein-3 -LRB- RAMP3 -RRB- expression primarily via 3 ' ,5 ' - cyclic_adenosine_monophosphate signaling in osteoblasts .
16075364	0	receptor_activity_modifying_protein-3	28,65	RAMP3	67,72	receptor activity modifying protein-3	RAMP3	56089(Tax:10090)	56089(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Parathyroid_hormone induces receptor_activity_modifying_protein-3 -LRB- RAMP3 -RRB- expression primarily via 3 ' ,5 ' - cyclic_adenosine_monophosphate signaling in osteoblasts .
11997247	0	receptor_activity_modifying_protein-3	61,98	adrenomedullin_receptor	20,43	receptor activity modifying protein-3	adrenomedullin receptor	56820(Tax:10116)	29307(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|nmod|END_ENTITY	Novel regulation of adrenomedullin_receptor by PDGF : role of receptor_activity_modifying_protein-3 .
24454825	0	receptor_activity_modifying_protein_1	8,45	calcium_sensing_receptor	65,89	receptor activity modifying protein 1	calcium sensing receptor	10267	846	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of receptor_activity_modifying_protein_1 in function of the calcium_sensing_receptor in the human TT_thyroid_carcinoma cell line .
3000665	2	receptor_and_transferrin_receptor	53,86	Interleukin_2	39,52	receptor and transferrin receptor	Interleukin 2	3558	3558	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Interleukin_2 receptor_and_transferrin_receptor expression on T cells and production of interleukin_2 in patients with acquired_immune_deficiency_syndrome -LRB- AIDS -RRB- and AIDS-related_complex .
3000665	2	receptor_and_transferrin_receptor	53,86	interleukin_2	127,140	receptor and transferrin receptor	interleukin 2	3558	3558	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Interleukin_2 receptor_and_transferrin_receptor expression on T cells and production of interleukin_2 in patients with acquired_immune_deficiency_syndrome -LRB- AIDS -RRB- and AIDS-related_complex .
17201176	0	receptor_for_activated_C-kinase_1	61,94	RACK1	96,101	receptor for activated C-kinase 1	RACK1	10399	10399	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The prion-like protein Doppel -LRB- Dpl -RRB- interacts with the human receptor_for_activated_C-kinase_1 -LRB- RACK1 -RRB- protein .
17158877	0	receptor_for_advanced_glycated_end_products	47,90	calgranulin_C	10,23	receptor for advanced glycated end products	calgranulin C	177	6283	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Hexameric calgranulin_C -LRB- S100A12 -RRB- binds to the receptor_for_advanced_glycated_end_products -LRB- RAGE -RRB- using symmetric hydrophobic target-binding patches .
25930197	0	receptor_for_advanced_glycation_end-products	10,54	IL-33	92,97	receptor for advanced glycation end-products	IL-33	177	77125(Tax:10090)	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Pulmonary receptor_for_advanced_glycation_end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells .
19164451	0	receptor_for_advanced_glycation_end-products	35,79	RAGE	81,85	receptor for advanced glycation end-products	RAGE	177	11596(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative splicing of the murine receptor_for_advanced_glycation_end-products -LRB- RAGE -RRB- gene .
22116960	0	receptor_for_advanced_glycation_end-products	28,72	RAGE	74,78	receptor for advanced glycation end-products	RAGE	177	177	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	2245G/A polymorphism of the receptor_for_advanced_glycation_end-products -LRB- RAGE -RRB- gene is associated with diabetic_retinopathy in the Malaysian population .
19201044	0	receptor_for_advanced_glycation_end_products	52,96	C-reactive_protein	0,18	receptor for advanced glycation end products	C-reactive protein	177	1401	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	C-reactive_protein -LRB- CRP -RRB- up-regulates expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- and its inflammatory ligand EN-RAGE in THP-1 cells : inhibitory effects of atorvastatin .
15341523	0	receptor_for_advanced_glycation_end_products	28,72	HNK-1	113,118	receptor for advanced glycation end products	HNK-1	11596(Tax:10090)	76898(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- , amphoterin and sulfoglucuronyl -LRB- HNK-1 -RRB- carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration .
20726326	0	receptor_for_advanced_glycation_end_products	19,63	RAGE	122,126	receptor for advanced glycation end products	RAGE	177	177	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of the receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- -374 _ T/A gene polymorphism and circulating soluble RAGE with nephropathy in type 1 diabetic patients .
20972729	0	receptor_for_advanced_glycation_end_products	19,63	RAGE	65,69	receptor for advanced glycation end products	RAGE	11596(Tax:10090)	11596(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of the receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- on bone metabolism under physiological and diabetic conditions .
22742537	0	receptor_for_advanced_glycation_end_products	99,143	RAGE	145,149	receptor for advanced glycation end products	RAGE	11596(Tax:10090)	11596(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Ligand-based design , synthesis , and biological evaluation of 2-aminopyrimidines , a novel series of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- inhibitors .
25718338	1	receptor_for_advanced_glycation_end_products	18,62	RAGE	64,68	receptor for advanced glycation end products	RAGE	177	177	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in intestinal fibrosis .
25888859	0	receptor_for_advanced_glycation_end_products	8,52	RAGE	54,58	receptor for advanced glycation end products	RAGE	177	177	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in liver_disease .
25888859	0	receptor_for_advanced_glycation_end_products	8,52	RAGE	54,58	receptor for advanced glycation end products	RAGE	177	177	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- in liver_disease .
9299542	0	receptor_for_advanced_glycation_end_products	50,94	RAGE	96,100	receptor for advanced glycation end products	RAGE	177	177	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Type II alveolar epithelial cells in lung express receptor_for_advanced_glycation_end_products -LRB- RAGE -RRB- gene .
23382057	0	receptor_for_hyaluronan-mediated_motility	14,55	RHAMM	57,62	receptor for hyaluronan-mediated motility	RHAMM	3161	3161	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of receptor_for_hyaluronan-mediated_motility -LRB- RHAMM -RRB- in ossifying fibromas .
24676428	0	receptor_for_hyaluronan-mediated_motility	8,49	RHAMM	51,56	receptor for hyaluronan-mediated motility	RHAMM	3161	3161	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of receptor_for_hyaluronan-mediated_motility -LRB- RHAMM -RRB- in human head_and_neck_cancers .
19339267	0	receptor_interacting_protein_1	4,34	p53	44,47	receptor interacting protein 1	p53	8737	7157	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|induction induction|compound|END_ENTITY	The receptor_interacting_protein_1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma .
9521594	0	receptor_interacting_protein_140	16,48	RIP140	50,56	receptor interacting protein 140	RIP140	8204	8204	Gene	Gene	Localisation|nmod|START_ENTITY Localisation|appos|END_ENTITY	Localisation of receptor_interacting_protein_140 -LRB- RIP140 -RRB- within 100 kb of D21S13 on 21q11 , a gene-poor region of the human genome .
22210188	0	receptor_of_activated_C_kinase_1	66,98	PIAS2	54,59	receptor of activated C kinase 1	PIAS2	10399	9063	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of protein_inhibitor_of_activated_STAT_2 -LRB- PIAS2 -RRB- with receptor_of_activated_C_kinase_1 , RACK1 .
22210188	0	receptor_of_activated_C_kinase_1	66,98	protein_inhibitor_of_activated_STAT_2	15,52	receptor of activated C kinase 1	protein inhibitor of activated STAT 2	10399	9063	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of protein_inhibitor_of_activated_STAT_2 -LRB- PIAS2 -RRB- with receptor_of_activated_C_kinase_1 , RACK1 .
21555911	0	receptor_tyrosine_kinase	68,92	AXL	64,67	receptor tyrosine kinase	AXL	5979	558	Gene	Gene	START_ENTITY|nsubj|Heritability Heritability|nmod|environment environment|nmod|methylation methylation|nmod|END_ENTITY	Heritability and role for the environment in DNA methylation in AXL receptor_tyrosine_kinase .
18522535	0	receptor_tyrosine_kinase	10,34	Axl	35,38	receptor tyrosine kinase	Axl	5979	558	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The human receptor_tyrosine_kinase Axl gene -- promoter characterization and regulation of constitutive expression by Sp1 , Sp3 and CpG methylation .
21135257	0	receptor_tyrosine_kinase	10,34	Axl	35,38	receptor tyrosine kinase	Axl	5979	558	Gene	Gene	START_ENTITY|ccomp|active active|nsubj|END_ENTITY	The novel receptor_tyrosine_kinase Axl is constitutively active in B-cell_chronic_lymphocytic_leukemia and acts as a docking site of nonreceptor kinases : implications for therapy .
22844123	0	receptor_tyrosine_kinase	98,122	Axl	94,97	receptor tyrosine kinase	Axl	5979	558	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Prostaglandin_E induces oncostatin_M expression in human chronic wound macrophages through Axl receptor_tyrosine_kinase pathway .
9130617	0	receptor_tyrosine_kinase	38,62	Axl	31,34	receptor tyrosine kinase	Axl	5979	558	Gene	Gene	progress|appos|START_ENTITY progress|nmod|role role|nmod|END_ENTITY	Recent progress on the role of Axl , a receptor_tyrosine_kinase , in malignant_transformation_of_myeloid_leukemias .
23690991	0	receptor_tyrosine_kinase	20,44	EGFR	66,70	receptor tyrosine kinase	EGFR	5979	1956	Gene	Gene	START_ENTITY|advcl|targeting targeting|dobj|END_ENTITY	miR-219-5p inhibits receptor_tyrosine_kinase pathway by targeting EGFR in glioblastoma .
15723799	0	receptor_tyrosine_kinase	58,82	ERK	30,33	receptor tyrosine kinase	ERK	38559(Tax:7227)	3354888(Tax:7227)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	Ras-independent activation of ERK signaling via the torso receptor_tyrosine_kinase is mediated by Rap1 .
25120806	0	receptor_tyrosine_kinase	24,48	EphB1	52,57	receptor tyrosine kinase	EphB1	5979	2047	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|protein protein|amod|END_ENTITY	Decreased expression of receptor_tyrosine_kinase of EphB1 protein in renal_cell_carcinomas .
12917021	0	receptor_tyrosine_kinase	27,51	HER-2	17,22	receptor tyrosine kinase	HER-2	5979	2064	Gene	Gene	phosphorylation|amod|START_ENTITY neu|dobj|phosphorylation inhibits|parataxis|neu inhibits|xcomp|END_ENTITY	-LSB- SUCI02 inhibits HER-2 / neu receptor_tyrosine_kinase phosphorylation and growth of HER-2 / neu-overexpressing breast_cancer cells -RSB- .
12917021	0	receptor_tyrosine_kinase	27,51	HER-2	82,87	receptor tyrosine kinase	HER-2	5979	2064	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	-LSB- SUCI02 inhibits HER-2 / neu receptor_tyrosine_kinase phosphorylation and growth of HER-2 / neu-overexpressing breast_cancer cells -RSB- .
8626139	0	receptor_tyrosine_kinase	62,86	HER-2	52,57	receptor tyrosine kinase	HER-2	5979	2064	Gene	Gene	induces|nsubj|START_ENTITY Transfection|parataxis|induces Transfection|nmod|END_ENTITY	Transfection of human ovarian_cancer cells with the HER-2 / neu receptor_tyrosine_kinase induces a selective increase in PTP-H1 , PTP-1B , PTP-alpha expression .
16166596	0	receptor_tyrosine_kinase	6,30	IGF-1	0,5	receptor tyrosine kinase	IGF-1	5979	3479	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	IGF-1 receptor_tyrosine_kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple_myeloma cells .
11522667	0	receptor_tyrosine_kinase	18,42	KIT	43,46	receptor tyrosine kinase	KIT	22174(Tax:10090)	16590(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of the receptor_tyrosine_kinase KIT in mature beta-cells and in the pancreas in development .
22179835	0	receptor_tyrosine_kinase	4,28	Mer	0,3	receptor tyrosine kinase	Mer	5979	10461	Gene	Gene	inhibition|compound|START_ENTITY inhibition|compound|END_ENTITY	Mer receptor_tyrosine_kinase inhibition impedes glioblastoma multiforme migration and alters cellular morphology .
7633441	0	receptor_tyrosine_kinase	29,53	RET	25,28	receptor tyrosine kinase	RET	5979	5979	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|END_ENTITY	Mutation analysis of the RET receptor_tyrosine_kinase in Hirschsprung_disease .
11082293	0	receptor_tyrosine_kinase	41,65	RON	37,40	receptor tyrosine kinase	RON	5979	4486	Gene	Gene	START_ENTITY|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression and activation of the RON receptor_tyrosine_kinase in a panel of human colorectal_carcinoma cell lines .
11281194	0	receptor_tyrosine_kinase	52,76	RON	48,51	receptor tyrosine kinase	RON	5979	4486	Gene	Gene	START_ENTITY|nsubj|analysis analysis|nmod|distribution distribution|nmod|END_ENTITY	Immunohistochemical analysis of distribution of RON receptor_tyrosine_kinase in human digestive organs .
20363625	0	receptor_tyrosine_kinase	47,71	RON	43,46	receptor tyrosine kinase	RON	5979	4486	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Identification of a novel series of potent RON receptor_tyrosine_kinase inhibitors .
27102439	0	receptor_tyrosine_kinase	41,65	RUNX2	25,30	receptor tyrosine kinase	RUNX2	5979	860	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The transcription factor RUNX2 regulates receptor_tyrosine_kinase expression in melanoma .
11786211	0	receptor_tyrosine_kinase	18,42	Ret	14,17	receptor tyrosine kinase	Ret	24716(Tax:10116)	24716(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Ret receptor_tyrosine_kinase after transient forebrain_ischemia is modulated by glial_cell_line-derived_neurotrophic_factor in rat hippocampus .
16879925	0	receptor_tyrosine_kinase	16,40	Ret	12,15	receptor tyrosine kinase	Ret	24716(Tax:10116)	24716(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	The role of Ret receptor_tyrosine_kinase in dopaminergic neuron development .
20434834	0	receptor_tyrosine_kinase	43,67	Ron	39,42	receptor tyrosine kinase	Ron	22174(Tax:10090)	19882(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Acts Acts|nmod|synergy synergy|nmod|END_ENTITY	Chk2 * 1100delC Acts in synergy with the Ron receptor_tyrosine_kinase to accelerate mammary tumorigenesis in mice .
20689759	0	receptor_tyrosine_kinase	4,28	Ron	0,3	receptor tyrosine kinase	Ron	5979	4486	Gene	Gene	activation|compound|START_ENTITY activation|compound|END_ENTITY	Ron receptor_tyrosine_kinase activation confers resistance to tamoxifen in breast_cancer cell lines .
24739671	0	receptor_tyrosine_kinase	26,50	Ron	22,25	receptor tyrosine kinase	Ron	5979	4486	Gene	Gene	START_ENTITY|nsubj|Autoinhibition Autoinhibition|nmod|END_ENTITY	Autoinhibition of the Ron receptor_tyrosine_kinase by the juxtamembrane domain .
10949653	0	receptor_tyrosine_kinase	6,30	SHP2	59,63	receptor tyrosine kinase	SHP2	5979	5781	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Tie-1 receptor_tyrosine_kinase endodomain interaction with SHP2 : potential signalling mechanisms and roles in angiogenesis .
15031289	0	receptor_tyrosine_kinase	75,99	Shp2	0,4	receptor tyrosine kinase	Shp2	5979	5781	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Shp2 , an SH2-containing protein-tyrosine phosphatase , positively regulates receptor_tyrosine_kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty .
11071380	0	receptor_tyrosine_kinase	123,147	TRKA	94,98	receptor tyrosine kinase	TRKA	5979	4914	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with congenital_insensitivity_to_pain_with_anhidrosis .
11159935	0	receptor_tyrosine_kinase	129,153	TRKA	67,71	receptor tyrosine kinase	TRKA	5979	4914	Gene	Gene	autophosphorylation|nmod|START_ENTITY missense|nmod|autophosphorylation missense|nsubj|Congenital_insensitivity Congenital_insensitivity|dep|effect effect|nmod|END_ENTITY	Congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : effect of TRKA -LRB- NTRK1 -RRB- missense mutations on autophosphorylation of the receptor_tyrosine_kinase for nerve_growth_factor .
11748840	0	receptor_tyrosine_kinase	138,162	TRKA	107,111	receptor tyrosine kinase	TRKA	5979	4914	Gene	Gene	encoding|dobj|START_ENTITY mutations|acl|encoding mutations|nmod|gene gene|compound|END_ENTITY	Molecular basis of congenital_insensitivity to pain with anhidrosis -LRB- CIPA -RRB- : mutations and polymorphisms in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve_growth_factor .
12102460	1	receptor_tyrosine_kinase	213,237	TRKA	183,187	receptor tyrosine kinase	TRKA	5979	4914	Gene	Gene	encoding|dobj|START_ENTITY aspects|acl|encoding aspects|nmod|mutations mutations|nmod|gene gene|compound|END_ENTITY	Clinical , biological and molecular aspects of mutations in TRKA -LRB- NTRK1 -RRB- gene encoding the receptor_tyrosine_kinase for nerve growth factor .
12210794	0	receptor_tyrosine_kinase	48,72	TRKA	19,23	receptor tyrosine kinase	TRKA	5979	4914	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	No mutation in the TRKA -LRB- NTRK1 -RRB- gene encoding a receptor_tyrosine_kinase for nerve growth factor in a patient with hereditary_sensory_and_autonomic_neuropathy_type_V .
9233584	0	receptor_tyrosine_kinase	16,40	Tie	12,15	receptor tyrosine kinase	Tie	5979	7075	Gene	Gene	START_ENTITY|nsubj|Analysis Analysis|nmod|END_ENTITY	Analysis of Tie receptor_tyrosine_kinase in haemopoietic progenitor and leukaemia cells .
10949653	0	receptor_tyrosine_kinase	6,30	Tie-1	0,5	receptor tyrosine kinase	Tie-1	5979	7075	Gene	Gene	interaction|amod|START_ENTITY interaction|amod|END_ENTITY	Tie-1 receptor_tyrosine_kinase endodomain interaction with SHP2 : potential signalling mechanisms and roles in angiogenesis .
9292513	0	receptor_tyrosine_kinase	30,54	TrkA	25,29	receptor tyrosine kinase	TrkA	5979	4914	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of functional TrkA receptor_tyrosine_kinase in the HMC-1 human mast cell line and in human mast cells .
16230391	0	receptor_tyrosine_kinase	23,47	axl	48,51	receptor tyrosine kinase	axl	5979	558	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	Multiple roles for the receptor_tyrosine_kinase axl in tumor formation .
1384789	0	receptor_tyrosine_kinase	31,55	tie	27,30	receptor tyrosine kinase	tie	5979	7075	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Enhanced expression of the tie receptor_tyrosine_kinase in endothelial cells during neovascularization .
9301679	0	receptor_tyrosine_kinase	18,42	tie	14,17	receptor tyrosine kinase	tie	5979	7075	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of tie receptor_tyrosine_kinase in human leukemia cell lines .
8833149	0	receptor_tyrosine_phosphatase_gamma	23,58	PTPRG	65,70	receptor tyrosine phosphatase gamma	PTPRG	5793	5793	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the human receptor_tyrosine_phosphatase_gamma gene -LRB- PTPRG -RRB- and relation to the familial_RCC_t -LRB- 3 ; 8 -RRB- chromosome translocation .
8934654	0	recombinase-activating_gene	18,45	RAG-1	47,52	recombinase-activating gene	RAG-1	19373(Tax:10090)	19373(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the recombinase-activating_gene -LRB- RAG-1 -RRB- in murine early embryogenesis .
12244173	0	recombination-activating_gene-2	59,90	c-Myb	114,119	recombination-activating gene-2	c-Myb	5897	4602	Gene	Gene	promoter|amod|START_ENTITY activates|dobj|promoter activates|nmod|END_ENTITY	Lymphoid_enhancer-binding_factor-1 binds and activates the recombination-activating_gene-2 promoter together with c-Myb and Pax-5 in immature B cells .
1986864	0	recombination_activating_gene-1	4,35	RAG-1	37,42	recombination activating gene-1	RAG-1	19373(Tax:10090)	19373(Tax:10090)	Gene	Gene	transcript|amod|START_ENTITY transcript|compound|END_ENTITY	The recombination_activating_gene-1 -LRB- RAG-1 -RRB- transcript is present in the murine central nervous system .
10219001	0	recombination_activating_gene_1	18,49	RAG-1	51,56	recombination activating gene 1	RAG-1	19373(Tax:10090)	19373(Tax:10090)	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Activation of the recombination_activating_gene_1 -LRB- RAG-1 -RRB- transcript in bone marrow of senescent C57BL/6 mice by recombinant interleukin-7 .
1280427	0	recoverin	73,82	hippocalcin	21,32	recoverin	hippocalcin	140936(Tax:10116)	29177(Tax:10116)	Gene	Gene	family|compound|START_ENTITY protein|nmod|family END_ENTITY|appos|protein	Molecular cloning of hippocalcin , a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus .
8617359	0	recoverin	14,23	rhodopsin	32,41	recoverin	rhodopsin	5957	6010	Gene	Gene	targets|compound|START_ENTITY END_ENTITY|nsubj|targets	Calcium-bound recoverin targets rhodopsin kinase to membranes to inhibit rhodopsin phosphorylation .
23148211	0	redox_factor-1	96,110	Protein-disulfide_isomerase	0,27	redox factor-1	Protein-disulfide isomerase	79116(Tax:10116)	25506(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Protein-disulfide_isomerase regulates the thyroid hormone receptor-mediated gene expression via redox_factor-1 through thiol reduction-oxidation .
19687280	0	reduced_folate_carrier	134,156	reduced_folate_carrier	45,67	reduced folate carrier	reduced folate carrier	424034(Tax:9031)	424034(Tax:9031)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and tissue distribution of reduced_folate_carrier and effect of dietary folate supplementation on the expression of reduced_folate_carrier in laying hens .
19687280	0	reduced_folate_carrier	45,67	reduced_folate_carrier	134,156	reduced folate carrier	reduced folate carrier	424034(Tax:9031)	424034(Tax:9031)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and tissue distribution of reduced_folate_carrier and effect of dietary folate supplementation on the expression of reduced_folate_carrier in laying hens .
16741749	0	reductase	106,115	FRO2	122,126	reductase	FRO2	547911(Tax:3847)	839411(Tax:3702)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular and phenotypic characterization of transgenic soybean expressing the Arabidopsis ferric chelate reductase gene , FRO2 .
16102527	0	reelin	10,16	Apoer2	0,6	reelin	Apoer2	5649	7804	Gene	Gene	receptor|amod|START_ENTITY END_ENTITY|dep|receptor	Apoer2 : a reelin receptor to remember .
9728912	0	reelin	15,21	BDNF	0,4	reelin	BDNF	19699(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	BDNF regulates reelin expression and Cajal-Retzius cell development in the cerebral cortex .
17182786	0	reelin	47,53	Collapsin_response_mediator_protein_1	0,37	reelin	Collapsin response mediator protein 1	19699(Tax:10090)	12933(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Collapsin_response_mediator_protein_1 mediates reelin signaling in cortical neuronal migration .
11074872	0	reelin	12,18	GAD67	54,59	reelin	GAD67	5649	2571	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Decrease in reelin and glutamic_acid decarboxylase67 -LRB- GAD67 -RRB- expression in schizophrenia and bipolar_disorder : a postmortem brain study .
15717292	0	reelin	24,30	RELN	32,36	reelin	RELN	5649	5649	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Hypermethylation of the reelin -LRB- RELN -RRB- promoter in the brain of schizophrenic patients : a preliminary report .
20734148	0	reelin	22,28	RELN	30,34	reelin	RELN	5649	5649	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Reduced expression of reelin -LRB- RELN -RRB- gene is associated with high recurrence rate of hepatocellular_carcinoma .
21863557	0	reelin	51,57	RELN	59,63	reelin	RELN	5649	5649	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new single-nucleotide mutation -LRB- rs362719 -RRB- of the reelin -LRB- RELN -RRB- gene associated with schizophrenia in female Chinese Han .
15175076	0	reelin	4,10	disabled-1	30,40	reelin	disabled-1	5649	1600	Gene	Gene	components|amod|START_ENTITY components|amod|END_ENTITY	The reelin pathway components disabled-1 and p35 in gangliogliomas -- a mutation and expression analysis .
18237558	0	reelin	12,18	reelin	95,101	reelin	reelin	5649	5649	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|compound|END_ENTITY	The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene .
18237558	0	reelin	95,101	reelin	12,18	reelin	reelin	5649	5649	Gene	Gene	gene|compound|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	The role of reelin in adult synaptic function and the genetic and epigenetic regulation of the reelin gene .
21753853	0	reg	67,70	CCL28	55,60	reg	CCL28	5967	56477	Gene	Gene	cells|compound|START_ENTITY cells|compound|END_ENTITY	Tumour_hypoxia promotes tolerance and angiogenesis via CCL28 and T -LRB- reg -RRB- cells .
7720628	0	reg	95,98	peptide-23	23,33	reg	peptide-23	24714(Tax:10116)	24618(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|changes changes|nmod|END_ENTITY	Age-related changes in peptide-23 / pancreatitis-associated protein and pancreatic_stone_protein / reg gene expression in the rat and regulation by growth_hormone-releasing_hormone .
21779798	0	regucalcin	46,56	RGN	58,61	regucalcin	RGN	100653478	100653478	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparative molecular characterization of the regucalcin -LRB- RGN -RRB- gene in rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- and maraena whitefish -LRB- Coregonus marena -RRB- .
21951853	0	regucalcin	37,47	RGN	49,52	regucalcin	RGN	403070(Tax:7955)	403070(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Senescence marker protein 30 -LRB- SMP30 -RRB- / regucalcin -LRB- RGN -RRB- expression decreases with aging , acute liver_injuries and tumors in zebrafish .
24412152	0	regulated_in_development_and_DNA_damage_response_2	54,104	Interferon_regulatory_factor-1	0,30	regulated in development and DNA damage response 2	Interferon regulatory factor-1	73284(Tax:10090)	16362(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- interacts with regulated_in_development_and_DNA_damage_response_2 -LRB- REDD2 -RRB- in the cytoplasm of mouse bone marrow cells .
19268525	0	regulated_in_development_and_DNA_damage_response_2	4,54	REDD2	56,61	regulated in development and DNA damage response 2	REDD2	115265	115265	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The regulated_in_development_and_DNA_damage_response_2 -LRB- REDD2 -RRB- gene mediates human monocyte cell death through a reduction in thioredoxin-1 expression .
16602627	0	regulated_upon_activation_normal_T_cell_expressed_and_secreted	34,96	TNF-alpha	112,121	regulated upon activation normal T cell expressed and secreted	TNF-alpha	81780(Tax:10116)	24835(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Rat peritoneal mast cells release regulated_upon_activation_normal_T_cell_expressed_and_secreted -LRB- RANTES -RRB- after TNF-alpha activation .
21620966	0	regulator_of_G-protein_signaling-17	35,70	RGS17	72,77	regulator of G-protein signaling-17	RGS17	26575	26575	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Altered expression and function of regulator_of_G-protein_signaling-17 -LRB- RGS17 -RRB- in hepatocellular_carcinoma .
11968023	0	regulator_of_G-protein_signaling-2	12,46	RGS-2	48,53	regulator of G-protein signaling-2	RGS-2	84583(Tax:10116)	84583(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of regulator_of_G-protein_signaling-2 -LRB- RGS-2 -RRB- expression and function in osteoblastic cells .
22057271	0	regulator_of_G-protein_signaling-2	49,83	RGS2	85,89	regulator of G-protein signaling-2	RGS2	5997	5997	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Identification of a cAMP-response element in the regulator_of_G-protein_signaling-2 -LRB- RGS2 -RRB- promoter as a key cis-regulatory element for RGS2 transcriptional regulation by angiotensin_II in cultured vascular smooth muscles .
23533674	0	regulator_of_G-protein_signaling_10	79,114	RGS10	116,121	regulator of G-protein signaling 10	RGS10	6001	6001	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional suppression , DNA methylation , and histone deacetylation of the regulator_of_G-protein_signaling_10 -LRB- RGS10 -RRB- gene in ovarian_cancer cells .
17294519	0	regulator_of_G-protein_signaling_2	8,42	RGS2	44,48	regulator of G-protein signaling 2	RGS2	5997	5997	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of regulator_of_G-protein_signaling_2 -LRB- RGS2 -RRB- in periodontal ligament cells under mechanical stress .
11326297	0	regulator_of_G-protein_signaling_4	28,62	RGS4	64,68	regulator of G-protein signaling 4	RGS4	5999	5999	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Disease-specific changes in regulator_of_G-protein_signaling_4 -LRB- RGS4 -RRB- expression in schizophrenia .
24229325	0	regulator_of_G-protein_signaling_4	42,76	RGS4	78,82	regulator of G-protein signaling 4	RGS4	5999	5999	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nsubj|inhibition	Modification and functional inhibition of regulator_of_G-protein_signaling_4 -LRB- RGS4 -RRB- by 4-hydroxy-2-nonenal .
17071056	0	regulator_of_G-protein_signalling_4	22,57	RGS4	59,63	regulator of G-protein signalling 4	RGS4	5999	5999	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Altered expression of regulator_of_G-protein_signalling_4 -LRB- RGS4 -RRB- mRNA in the superior temporal gyrus in schizophrenia .
12968938	0	regulator_of_G-protein_signalling_protein_2	14,57	RGS2	59,63	regulator of G-protein signalling protein 2	RGS2	19735(Tax:10090)	19735(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of regulator_of_G-protein_signalling_protein_2 -LRB- RGS2 -RRB- in the mouse uterus at implantation sites .
18398336	0	regulator_of_G_protein_signaling-2	10,44	angiotensin_II	63,77	regulator of G protein signaling-2	angiotensin II	5997	183	Gene	Gene	increases|nsubj|START_ENTITY increases|dobj|END_ENTITY	Silencing regulator_of_G_protein_signaling-2 -LRB- RGS-2 -RRB- increases angiotensin_II signaling : insights into hypertension from findings in Bartter 's / Gitelman 's _ syndromes .
23817783	0	regulator_of_G_protein_signaling_14	38,73	RGS14	75,80	regulator of G protein signaling 14	RGS14	51791(Tax:10090)	51791(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Postnatal developmental expression of regulator_of_G_protein_signaling_14 -LRB- RGS14 -RRB- in the mouse brain .
20562099	0	regulator_of_G_protein_signaling_19	11,46	RGS19	48,53	regulator of G protein signaling 19	RGS19	56470(Tax:10090)	56470(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of regulator_of_G_protein_signaling_19 -LRB- RGS19 -RRB- on heart development and function .
23587726	0	regulator_of_G_protein_signaling_2	32,66	HSF1	109,113	regulator of G protein signaling 2	HSF1	5997	3297	Gene	Gene	transcription|nmod|START_ENTITY transcription|nmod|END_ENTITY	Stress-induced transcription of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- by heat_shock transcription factor HSF1 .
19175184	0	regulator_of_G_protein_signaling_2	66,100	LH_receptor	14,25	regulator of G protein signaling 2	LH receptor	5997	3973	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of LH_receptor and PGF2alpha_receptor signaling by the regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- in human and mouse granulosa cells .
15292238	0	regulator_of_G_protein_signaling_2	8,42	RGS2	134,138	regulator of G protein signaling 2	RGS2	19735(Tax:10090)	19735(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- in Ca -LRB- 2 + -RRB- oscillations and adaptation of Ca -LRB- 2 + -RRB- signaling to reduce excitability of RGS2 - / - cells .
18726905	0	regulator_of_G_protein_signaling_2	58,92	RGS2	94,98	regulator of G protein signaling 2	RGS2	19735(Tax:10090)	19735(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the transcriptional regulation of the regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- gene during 3T3-L1 preadipocyte differentiation .
20032508	0	regulator_of_G_protein_signaling_2	17,51	RGS2	53,57	regulator of G protein signaling 2	RGS2	84583(Tax:10116)	84583(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Ischemia induces regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- protein upregulation and enhances apoptosis in astrocytes .
23587726	0	regulator_of_G_protein_signaling_2	32,66	RGS2	68,72	regulator of G protein signaling 2	RGS2	5997	5997	Gene	Gene	transcription|nmod|START_ENTITY transcription|appos|END_ENTITY	Stress-induced transcription of regulator_of_G_protein_signaling_2 -LRB- RGS2 -RRB- by heat_shock transcription factor HSF1 .
23977258	0	regulator_of_G_protein_signaling_4	67,101	RGS4	103,107	regulator of G protein signaling 4	RGS4	29480(Tax:10116)	29480(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Splicing factor transformer-2b -LRB- Tra2b -RRB- regulates the expression of regulator_of_G_protein_signaling_4 -LRB- RGS4 -RRB- gene and is induced by morphine .
12880183	0	regulator_of_G_protein_signaling_8	16,50	RGS8	52,56	regulator of G protein signaling 8	RGS8	54297(Tax:10116)	54297(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Distribution of regulator_of_G_protein_signaling_8 -LRB- RGS8 -RRB- protein in the cerebellum .
15095478	0	regulator_of_G_protein_signalling_protein_5	14,57	RGS5	59,63	regulator of G protein signalling protein 5	RGS5	8490	8490	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of regulator_of_G_protein_signalling_protein_5 -LRB- RGS5 -RRB- in the tumour vasculature of human renal_cell_carcinoma .
21890628	0	regulator_of_calcineurin_1	4,30	cAMP_response_element-binding_protein	59,96	regulator of calcineurin 1	cAMP response element-binding protein	1827	1385	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The regulator_of_calcineurin_1 -LRB- RCAN1/DSCR1 -RRB- activates the cAMP_response_element-binding_protein -LRB- CREB -RRB- pathway .
11336674	0	regulator_of_chromosome_condensation	63,99	Ran	52,55	regulator of chromosome condensation	Ran	1104	5901	Gene	Gene	exchange|nmod|START_ENTITY exchange|nmod|END_ENTITY	Structural basis for guanine_nucleotide exchange on Ran by the regulator_of_chromosome_condensation -LRB- RCC1 -RRB- .
17338827	0	regulator_of_telomere_length_elongation_helicase	46,94	RTEL	101,105	regulator of telomere length elongation helicase	RTEL	51750	505721(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterization of bovine regulator_of_telomere_length_elongation_helicase gene -LRB- RTEL -RRB- : molecular cloning , expression distribution , splice variants and DNA methylation profile .
14992813	0	regulators_of_G-protein_signaling	24,57	RGS	59,62	regulators of G-protein signaling	RGS	5308	5308	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Selective expression of regulators_of_G-protein_signaling -LRB- RGS -RRB- in the human central nervous system .
9207071	0	regulators_of_G_protein_signaling	4,37	RGS4	55,59	regulators of G protein signaling	RGS4	5308	5999	Gene	Gene	domains|compound|START_ENTITY domains|nmod|END_ENTITY	The regulators_of_G_protein_signaling -LRB- RGS -RRB- domains of RGS4 , RGS10 , and GAIP retain GTPase activating protein activity in vitro .
15830230	0	regulators_of_G_protein_signalling	27,61	RGS	63,66	regulators of G protein signalling	RGS	5308	5308	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Effector antagonism by the regulators_of_G_protein_signalling -LRB- RGS -RRB- proteins causes desensitization of mu-opioid receptors in the CNS .
8035474	0	rel	97,100	NF-kappa_B	86,96	rel	NF-kappa B	5966	4790	Gene	Gene	proteins|compound|START_ENTITY induction|dep|proteins induction|dep|modulation modulation|nmod|transcription transcription|nmod|END_ENTITY	Viral induction of the human beta interferon promoter : modulation of transcription by NF-kappa_B / rel proteins and interferon regulatory factors .
8352966	0	rel	29,32	NF-kappa_B	18,28	rel	NF-kappa B	5966	4790	Gene	Gene	factor|compound|START_ENTITY Regulation|dep|factor Regulation|nmod|END_ENTITY	Regulation of the NF-kappa_B / rel transcription factor and I kappa B inhibitor system .
8918242	0	relA	22,26	NF-kappa_B	32,42	relA	NF-kappa B	19697(Tax:10090)	18033(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the murine relA -LRB- p65 NF-kappa_B -RRB- gene and comparison to the human gene reveals a distinct first intron .
8833654	0	rel_A	69,74	p65	98,101	rel A	p65	309165(Tax:10116)	25716(Tax:10116)	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
9242628	0	related_adhesion_focal_tyrosine_kinase	4,42	p130Cas	73,80	related adhesion focal tyrosine kinase	p130Cas	2185	9564	Gene	Gene	phosphorylates|nsubj|START_ENTITY phosphorylates|dobj|END_ENTITY	The related_adhesion_focal_tyrosine_kinase differentially phosphorylates p130Cas and the Cas-like protein , p105HEF1 .
8995252	0	related_adhesion_focal_tyrosine_kinase	4,42	p130cas	127,134	related adhesion focal tyrosine kinase	p130cas	2185	9564	Gene	Gene	tyrosine-phosphorylated|nsubjpass|START_ENTITY tyrosine-phosphorylated|nmod|END_ENTITY	The related_adhesion_focal_tyrosine_kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas .
8345459	0	relaxin	37,44	relaxin	72,79	relaxin	relaxin	396891(Tax:9823)	396891(Tax:9823)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Stimulation of collagen secretion by relaxin and effect of oestrogen on relaxin binding in uterine cervical cells of pigs .
8345459	0	relaxin	72,79	relaxin	37,44	relaxin	relaxin	396891(Tax:9823)	396891(Tax:9823)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Stimulation of collagen secretion by relaxin and effect of oestrogen on relaxin binding in uterine cervical cells of pigs .
20214940	0	relaxin-3	23,32	Fos	41,44	relaxin-3	Fos	117579	314322(Tax:10116)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake .
15367576	0	relaxin-3	36,45	GPCR135	62,69	relaxin-3	GPCR135	117579	51289	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Pharmacological characterization of relaxin-3 / INSL7 receptors GPCR135 and GPCR142 from different mammalian species .
16679775	0	relaxin-3	120,129	GPCR135	162,169	relaxin-3	GPCR135	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	ligand|nsubj|START_ENTITY ligand|nmod|END_ENTITY	G-protein-coupled receptor -LRB- GPCR -RRB- -142 does not contribute to relaxin-3 binding in the mouse brain : further support that relaxin-3 is the physiological ligand for GPCR135 .
14522967	0	relaxin-3	18,27	INSL7	28,33	relaxin-3	INSL7	117579	117579	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of relaxin-3 / INSL7 as a ligand for GPCR142 .
22257012	0	relaxin-3	22,31	RXFP3	133,138	relaxin-3	RXFP3	117579	51289	Gene	Gene	Minimization|nmod|START_ENTITY Minimization|nmod|relaxin-family_peptide_3_receptor relaxin-family_peptide_3_receptor|appos|END_ENTITY	Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family_peptide_3_receptor -LRB- RXFP3 -RRB- over RXFP1 .
22854307	0	relaxin-3	94,103	RXFP3	85,90	relaxin-3	RXFP3	266997(Tax:10116)	294807(Tax:10116)	Gene	Gene	peptides|amod|START_ENTITY weight_gain|nmod|peptides weight_gain|nmod|activation activation|nmod|END_ENTITY	Increased feeding and body weight_gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides : functional and therapeutic implications .
23380674	0	relaxin-3	8,17	RXFP3	28,33	relaxin-3	RXFP3	266997(Tax:10116)	294807(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Central relaxin-3 receptor -LRB- RXFP3 -RRB- activation decreases_anxiety - _ and_depressive-like_behaviours in the rat .
23440673	0	relaxin-3	15,24	RXFP3	76,81	relaxin-3	RXFP3	117579	51289	Gene	Gene	interactions|amod|START_ENTITY Elucidation|nmod|interactions Elucidation|nmod|END_ENTITY	Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3 .
24615237	0	relaxin-3	173,182	RXFP3	92,97	relaxin-3	RXFP3	117579	51289	Gene	Gene	residues|nmod|START_ENTITY charged|dobj|residues positively|acl|charged charged|nmod|positively charged|dobj|Glu141 Glu141|nmod|interact interact|compound|END_ENTITY	The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3 .
24681162	0	relaxin-3	21,30	RXFP3	41,46	relaxin-3	RXFP3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY injection|nmod|receptor injection|appos|END_ENTITY	Central injection of relaxin-3 receptor -LRB- RXFP3 -RRB- antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice .
25257104	0	relaxin-3	111,120	RXFP3	121,126	relaxin-3	RXFP3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
26057358	0	relaxin-3	8,17	RXFP3	28,33	relaxin-3	RXFP3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Central relaxin-3 receptor -LRB- RXFP3 -RRB- activation reduces elevated , but not basal , anxiety-like behaviour in C57BL/6J mice .
26607097	0	relaxin-3	8,17	RXFP3	18,23	relaxin-3	RXFP3	266997(Tax:10116)	294807(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|system system|nummod|END_ENTITY	Role of relaxin-3 / RXFP3 system in stress-induced binge-like eating in female rats .
25257104	0	relaxin-3	111,120	Rxfp3	20,25	relaxin-3	Rxfp3	212108(Tax:10090)	239336(Tax:10090)	Gene	Gene	signalling|amod|START_ENTITY role|nmod|signalling Implications|nmod|role receptor|dep|Implications receptor|appos|END_ENTITY	Relaxin-3 receptor -LRB- Rxfp3 -RRB- gene knockout mice display reduced running wheel activity : Implications for role of relaxin-3 / RXFP3 signalling in sustained arousal .
15708846	0	relaxin-like_factor	30,49	LGR8	0,4	relaxin-like factor	LGR8	6018	122042	Gene	Gene	signal|nmod|START_ENTITY signal|nsubj|END_ENTITY	LGR8 signal activation by the relaxin-like_factor .
10542371	0	relaxin-like_factor	36,55	RLF	57,60	relaxin-like factor	RLF	114215(Tax:10116)	114215(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure and expression of the rat relaxin-like_factor -LRB- RLF -RRB- gene .
10759163	0	relaxin-like_factor	35,54	RLF	56,59	relaxin-like factor	RLF	6018	6018	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common polymorphism in the human relaxin-like_factor -LRB- RLF -RRB- gene : no relationship with cryptorchidism .
17870193	0	relaxin_3	56,65	INSL7	66,71	relaxin 3	INSL7	266997(Tax:10116)	266997(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Developmental expression and serotonergic regulation of relaxin_3 / INSL7 in the nucleus incertus of rat brain .
1544318	0	renal_dipeptidase	24,41	DPEP1	48,53	renal dipeptidase	DPEP1	1800	1800	Gene	Gene	gene|compound|START_ENTITY Assignment|nmod|gene Assignment|appos|END_ENTITY	Assignment of the human renal_dipeptidase gene -LRB- DPEP1 -RRB- to band q24 of chromosome 16 .
7649582	0	renin	25,30	Amylin	0,6	renin	Amylin	5972	3375	Gene	Gene	concentration|compound|START_ENTITY stimulates|dobj|concentration stimulates|nsubj|END_ENTITY	Amylin stimulates plasma renin concentration in humans .
8779889	0	renin	94,99	Amylin	0,6	renin	Amylin	24715(Tax:10116)	24476(Tax:10116)	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Amylin binding in rat renal cortex , stimulation of adenylyl cyclase , and activation of plasma renin .
11799102	0	renin	58,63	Angiotensin_II	0,14	renin	Angiotensin II	5972	183	Gene	Gene	Aliskiren|compound|START_ENTITY humans|nmod|Aliskiren suppression|nmod|humans suppression|compound|END_ENTITY	Angiotensin_II suppression in humans by the orally active renin inhibitor Aliskiren -LRB- SPP100 -RRB- : comparison with enalapril .
12010742	0	renin	55,60	Angiotensin_II	0,14	renin	Angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	COX-2|compound|START_ENTITY regulator|nmod|COX-2 regulator|nsubj|feedback feedback|compound|END_ENTITY	Angiotensin_II feedback is a regulator of renocortical renin , COX-2 , and nNOS expression .
15238629	0	renin	35,40	Angiotensin_II	0,14	renin	Angiotensin II	5972	183	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Angiotensin_II activates the human renin promoter in an in vitro model : the role of c-Jun-N-terminal_kinase .
17376010	0	renin	119,124	Angiotensin_II	0,14	renin	Angiotensin II	5972	183	Gene	Gene	inhibition|compound|START_ENTITY reactivation|parataxis|inhibition reactivation|compound|END_ENTITY	Angiotensin_II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade : is oral renin inhibition the solution ?
21282553	0	renin	26,31	Angiotensin_II	0,14	renin	Angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates renin in inner medullary collecting duct cells via protein kinase C and independent of epithelial sodium channel and mineralocorticoid receptor activity .
2260680	0	renin	25,30	Angiotensin_II	0,14	renin	Angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Angiotensin_II regulates renin gene expression .
23266540	0	renin	38,43	Angiotensin_II	0,14	renin	Angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY independent|nmod|activity END_ENTITY|appos|independent	Angiotensin_II , independent of plasma renin activity , contributes to the hypertension of autonomic_failure .
474181	0	renin	63,68	Angiotensin_II	0,14	renin	Angiotensin II	5972	183	Gene	Gene	electrolytes|compound|START_ENTITY relationship|nmod|electrolytes END_ENTITY|appos|relationship	Angiotensin_II in primary hypertension , relationship to plasma renin activity , aldosterone and urinary electrolytes .
6170618	0	renin	30,35	Angiotensin_II	0,14	renin	Angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	cells|appos|START_ENTITY END_ENTITY|nmod|cells	Angiotensin_II in epitheloid -LRB- renin containing -RRB- cells of rat kidney .
6752538	0	renin	48,53	Angiotensin_II	0,14	renin	Angiotensin II	5972	183	Gene	Gene	coexisting|nmod|START_ENTITY END_ENTITY|acl|coexisting	Angiotensin_II immunoreactivity coexisting with renin in the human juxtaglomerular epithelioid cells .
7022457	0	renin	46,51	Angiotensin_II	0,14	renin	Angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	coexists|nmod|START_ENTITY coexists|nsubj|END_ENTITY	Angiotensin_II immunoreactivity coexists with renin in the juxtaglomerular granular cells of the kidney .
846071	0	renin	54,59	Angiotensin_II	0,14	renin	Angiotensin II	5972	183	Gene	Gene	interaction|nmod|START_ENTITY blockade|dep|interaction blockade|compound|END_ENTITY	Angiotensin_II blockade in normal man : interaction of renin and sodium in maintaining blood pressure .
2698948	0	renin	130,135	Angiotensin_converting_enzyme	0,29	renin	Angiotensin converting enzyme	5972	1636	Gene	Gene	levels|compound|START_ENTITY autonomic_failure|nmod|levels patients|nmod|autonomic_failure lowers|nmod|patients lowers|nsubj|inhibition inhibition|amod|END_ENTITY	Angiotensin_converting_enzyme inhibition lowers blood pressure in patients with primary autonomic_failure independently of plasma renin levels and sympathetic nervous activity .
8833654	0	renin	147,152	Angiotensinogen	0,15	renin	Angiotensinogen	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	loop|compound|START_ENTITY mechanism|nmod|loop factor|dep|mechanism mediated|nmod|factor mediated|nsubjpass|activation activation|compound|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
9781693	0	renin	28,33	Angiotensinogen	0,15	renin	Angiotensinogen	5972	183	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Angiotensinogen cleavage by renin : importance of a structurally constrained N-terminus .
9886872	0	renin	105,110	Angiotensinogen	0,15	renin	Angiotensinogen	5972	183	Gene	Gene	polymorphisms|nmod|START_ENTITY polymorphisms|nsubj|END_ENTITY	Angiotensinogen -LRB- M235T -RRB- and angiotensin-converting_enzyme -LRB- I/D -RRB- polymorphisms in association with plasma renin and prorenin levels .
2476609	0	renin	72,77	Atrial_natriuretic_factor	0,25	renin	Atrial natriuretic factor	5972	4878	Gene	Gene	activity|compound|START_ENTITY attenuates|dobj|activity attenuates|nsubj|END_ENTITY	Atrial_natriuretic_factor attenuates prostaglandin_E2-stimulated plasma renin activity in humans .
2571299	0	renin	59,64	Atrial_natriuretic_factor	0,25	renin	Atrial natriuretic factor	403838(Tax:9615)	608289(Tax:9615)	Gene	Gene	release|compound|START_ENTITY stimulation|nmod|release suppresses|dobj|stimulation suppresses|nsubj|END_ENTITY	Atrial_natriuretic_factor suppresses neural stimulation of renin release in dogs .
2535241	0	renin	35,40	Atrial_natriuretic_peptide	0,26	renin	Atrial natriuretic peptide	5972	4878	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|appos|activity	Atrial_natriuretic_peptide , plasma renin activity , plasma volume , systemic vascular resistance and cardiac output in patients with cirrhosis .
2949634	0	renin	34,39	Atrial_natriuretic_peptide	0,26	renin	Atrial natriuretic peptide	24715(Tax:10116)	24602(Tax:10116)	Gene	Gene	response|compound|START_ENTITY blocks|dobj|response blocks|nsubj|END_ENTITY	Atrial_natriuretic_peptide blocks renin response to renal_hypotension .
12434137	0	renin	67,72	COX-2	29,34	renin	COX-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Effects of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on plasma and renal renin in diabetes .
2841355	0	renin	51,56	Calcitonin_gene-related_peptide	0,31	renin	Calcitonin gene-related peptide	24715(Tax:10116)	24241(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY stimulator|nmod|secretion stimulator|nsubj|END_ENTITY	Calcitonin_gene-related_peptide is a stimulator of renin secretion .
10406830	0	renin	38,43	Cyclooxygenase-2	0,16	renin	Cyclooxygenase-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	content|compound|START_ENTITY decreases|dobj|content decreases|nsubj|inhibition inhibition|amod|END_ENTITY	Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular_hypertension .
12560203	0	renin	41,46	Cyclooxygenase-2	0,16	renin	Cyclooxygenase-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Cyclooxygenase-2 contributes to elevated renin in the early postnatal period in rats .
1145901	0	renin	37,42	Dopamine-beta-hydroxylase	0,25	renin	Dopamine-beta-hydroxylase	5972	1621	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Dopamine-beta-hydroxylase and plasma renin activity in twenty hypertensive subjects .
428086	0	renin	37,42	Dopamine_beta-hydroxylase	0,25	renin	Dopamine beta-hydroxylase	5972	1621	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Dopamine_beta-hydroxylase and plasma renin activity in patients with low - , normal - , and high-renin essential_hypertension .
8724359	0	renin	55,60	Interferon-gamma	0,16	renin	Interferon-gamma	5972	3458	Gene	Gene	synthesis|nmod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits the synthesis and release of renin from human decidual cells .
26537340	0	renin	19,24	Jagged1	8,15	renin	Jagged1	5972	182	Gene	Gene	progenitors|compound|START_ENTITY END_ENTITY|nmod|progenitors	Loss of Jagged1 in renin progenitors leads to focal kidney_fibrosis .
7898071	0	renin	41,46	Neuropeptide_Y	0,14	renin	Neuropeptide Y	24715(Tax:10116)	24604(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY decreases|dobj|activity decreases|nsubj|infusion infusion|amod|END_ENTITY	Neuropeptide_Y infusion decreases plasma renin activity in postmyocardial_infarction rats .
1714830	0	renin	64,69	Parathyroid_hormone	0,19	renin	Parathyroid hormone	24715(Tax:10116)	24694(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY control|nmod|secretion interactions|nmod|control END_ENTITY|dep|interactions	Parathyroid_hormone and calcium : interactions in the control of renin secretion in the isolated , nonfiltering rat kidney .
22649069	0	renin	54,59	Parathyroid_hormone-related_protein	0,35	renin	Parathyroid hormone-related protein	24715(Tax:10116)	24695(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Parathyroid_hormone-related_protein stimulates plasma renin activity via its anorexic effects on sodium_chloride intake .
26102248	0	renin	45,50	REN	52,55	renin	REN	5972	5972	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The C4280A -LRB- rs5705 -RRB- gene polymorphism of the renin -LRB- REN -RRB- gene is associated with risk of developing coronary_artery_disease , but not with restenosis after coronary stenting .
1026364	0	renin	7,12	Renin	0,5	renin	Renin	5972	5972	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	Renin , renin substrate and angiotensin_II concentration in renal venous blood .
6385771	0	renin	33,38	Renin	0,5	renin	Renin	5972	5972	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
1322277	0	renin	78,83	Transforming_growth_factor-beta_1	0,33	renin	Transforming growth factor-beta 1	280909(Tax:9913)	282089(Tax:9913)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 inhibits aldosterone and stimulates adrenal renin in cultured bovine zona glomerulosa cells .
10450835	0	renin	122,127	angiotensin_II	141,155	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Angiotensin_II_type_1_receptor expression in two cases of juxtaglomerular_cell_tumor : correlation to negative feedback of renin secretion by angiotensin_II .
10536699	0	renin	73,78	angiotensin_II	169,183	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	synthesize|dobj|START_ENTITY rat|acl:relcl|synthesize rat|dep|evidence evidence|nmod|cardiomyocyte cardiomyocyte|nmod|END_ENTITY	Cultured neonatal rat cardiac myocytes and fibroblasts do not synthesize renin or angiotensinogen : evidence for stretch-induced cardiomyocyte hypertrophy independent of angiotensin_II .
10555568	0	renin	54,59	angiotensin_II	73,87	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY inhibition|nmod|secretion attenuate|dobj|inhibition attenuate|nmod|END_ENTITY	Chloride channel blockers attenuate the inhibition of renin secretion by angiotensin_II .
1071608	0	renin	48,53	angiotensin_II	22,36	renin	angiotensin II	5972	183	Gene	Gene	START_ENTITY|nsubj|Dissociation Dissociation|nmod|END_ENTITY	Dissociation of blood angiotensin_II and plasma renin activity during chronic treatment in essential hypertension .
1077776	0	renin	20,25	angiotensin_II	75,89	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	response|nmod|START_ENTITY response|dep|systems systems|nmod|rats rats|nmod|injection injection|nmod|antibodies antibodies|amod|END_ENTITY	The response of the renin -- angiotensin systems in rats to the injection of angiotensin_II antibodies .
1126059	0	renin	23,28	angiotensin_II	7,21	renin	angiotensin II	5972	183	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|appos|concentrations	Plasma angiotensin_II , renin , renin-substrate and aldosterone concentrations in acute_renal_failure in man .
11403100	0	renin	23,28	angiotensin_II	7,21	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|appos|activity	Plasma angiotensin_II , renin activity and serum angiotensin-converting_enzyme activity in non-insulin_dependent_diabetes_mellitus patients with diabetic_nephropathy .
11702851	0	renin	116,121	angiotensin_II	68,82	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	receptors|appos|START_ENTITY receptors|amod|END_ENTITY	Nitric_oxide synthase mRNA levels correlate with gene expression of angiotensin_II type-1 but not type-2 receptors , renin or angiotensin converting enzyme in selected brain areas .
12045255	0	renin	99,104	angiotensin_II	47,61	renin	angiotensin II	5972	183	Gene	Gene	_|nmod|START_ENTITY _|nmod|production production|amod|END_ENTITY	Pivotal role of the renin/prorenin _ receptor in angiotensin_II production and cellular responses to renin .
1262200	0	renin	5,10	angiotensin_II	33,47	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|acl|accompanying accompanying|dobj|inhibition inhibition|amod|END_ENTITY	High renin activity accompanying angiotensin_II inhibition in rats with ischemic_renal_failure .
1312512	0	renin	28,33	angiotensin_II	10,24	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Effect of angiotensin_II on renin production by rat adrenal glomerulosa cells in culture .
15023936	0	renin	61,66	angiotensin_II	79,93	renin	angiotensin II	5972	183	Gene	Gene	response|compound|START_ENTITY phenotyping|dobj|response phenotyping|nmod|blockade blockade|amod|END_ENTITY	Integrating drug pharmacokinetics for phenotyping individual renin response to angiotensin_II blockade in humans .
15644940	0	renin	14,19	angiotensin_II	50,64	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	Conversion|nmod|START_ENTITY substrate|nsubj|Conversion substrate|xcomp|tetradecapeptide tetradecapeptide|nmod|END_ENTITY	Conversion of renin substrate tetradecapeptide to angiotensin_II by rat MAB elastase-2 .
15901242	0	renin	45,50	angiotensin_II	11,25	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY suppress|dobj|activity Failure|acl|suppress Failure|nmod|END_ENTITY	Failure of angiotensin_II to suppress plasma renin activity in normotensive subjects with a positive family history of hypertension .
16344366	0	renin	31,36	angiotensin_II	62,76	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	hypertension|compound|START_ENTITY oxidase|nmod|hypertension H|amod|oxidase H|dep|link link|nmod|END_ENTITY	Reduced NAD -LRB- P -RRB- H oxidase in low renin hypertension : link among angiotensin_II , atherogenesis , and blood pressure .
176034	0	renin	30,35	angiotensin_II	138,152	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY aldosterone|appos|activity Effect|nmod|aldosterone induced|nsubj|Effect induced|nmod|infusion infusion|nmod|END_ENTITY	Effect on plasma aldosterone , renin activity and cortisol of acute volume depletion induced by ethacrynic_acid under constant infusion of angiotensin_II and dexamethasone in man .
1856110	0	renin	12,17	angiotensin_II	36,50	renin	angiotensin II	5972	183	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of renin , angiotensinogen , angiotensin_II in the lamb anterior pituitary gland : immunocytochemical study after cryoultramicrotomy .
2171863	0	renin	71,76	angiotensin_II	9,23	renin	angiotensin II	5972	183	Gene	Gene	substrate|compound|START_ENTITY renin|dobj|substrate renin|nsubj|END_ENTITY	Platelet angiotensin_II binding and plasma renin concentration , plasma renin substrate and plasma angiotensin_II in human pregnancy .
21865264	0	renin	10,15	angiotensin_II	63,77	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	excretion|compound|START_ENTITY associated|nsubjpass|excretion associated|nmod|levels levels|compound|END_ENTITY	Increased renin excretion is associated with augmented urinary angiotensin_II levels in chronic angiotensin_II-infused hypertensive rats .
22222314	0	renin	61,66	angiotensin_II	94,108	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	inhibition|compound|START_ENTITY inhibition|nmod|receptors receptors|amod|END_ENTITY	Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin_II receptors in mRen2.Lewis hypertensive rats .
2447408	0	renin	32,37	angiotensin_II	49,63	renin	angiotensin II	5972	183	Gene	Gene	Inhibition|nmod|START_ENTITY release|nsubj|Inhibition release|nmod|END_ENTITY	Inhibition of captopril-induced renin release by angiotensin_II .
2537331	0	renin	58,63	angiotensin_II	24,38	renin	angiotensin II	5972	183	Gene	Gene	levels|compound|START_ENTITY infusion|nmod|levels infusion|nsubj|effect effect|nmod|END_ENTITY	No effect of short term angiotensin_II infusion on plasma renin substrate levels in man .
26268270	0	renin	105,110	angiotensin_II	75,89	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	PKC-a-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin_II stimulation of renin in the collecting_duct .
26377797	0	renin	55,60	angiotensin_II	21,35	renin	angiotensin II	5972	183	Gene	Gene	synthesis|compound|START_ENTITY collecting|dobj|synthesis END_ENTITY|acl|collecting	Reciprocal effect of angiotensin_II in collecting duct renin synthesis .
2843564	0	renin	12,17	angiotensin_II	96,110	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	granules|amod|START_ENTITY Presence|nmod|granules adrenal|nsubj|Presence adrenal|nmod|END_ENTITY	Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin_II but not by adrenocorticotropin .
2843564	0	renin	77,82	angiotensin_II	96,110	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY gland|nmod|secretion adrenal|dobj|gland adrenal|nmod|END_ENTITY	Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin_II but not by adrenocorticotropin .
2852078	0	renin	66,71	angiotensin_II	13,27	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	synthesis|compound|START_ENTITY Influence|nmod|synthesis Influence|nmod|END_ENTITY	Influence of angiotensin_II -LRB- AII -RRB- and angiotensin_I -LRB- AI -RRB- on renal renin synthesis and release .
3895792	0	renin	127,132	angiotensin_II	89,103	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY Relationships|appos|activity Relationships|appos|concentrations concentrations|amod|END_ENTITY	Relationships between blood pressure , heart rate and plasma epinephrine , norepinephrine , angiotensin_II concentrations , plasma renin activity during chronic guanfacine therapy in patients with essential arterial hypertension .
393505	0	renin	111,116	angiotensin_II	14,28	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY pressure|appos|activity isoleucine|nmod|pressure isoleucine|nsubj|Effects Effects|nmod|antagonist antagonist|amod|END_ENTITY	Effects of an angiotensin_II antagonist ; -LSB- sarcosine 1 , isoleucine 8 -RSB- angiotensin_II , on blood pressure , plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive subjects taking oral contraceptives .
393505	0	renin	111,116	angiotensin_II	69,83	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY pressure|appos|activity isoleucine|nmod|pressure isoleucine|dobj|END_ENTITY	Effects of an angiotensin_II antagonist ; -LSB- sarcosine 1 , isoleucine 8 -RSB- angiotensin_II , on blood pressure , plasma renin activity and plasma aldosterone concentration in hypertensive and normotensive subjects taking oral contraceptives .
4119172	0	renin	14,19	angiotensin_II	31,45	renin	angiotensin II	5972	183	Gene	Gene	substrate|compound|START_ENTITY renin|appos|substrate END_ENTITY|nsubj|renin	Plasma renin , renin substrate , angiotensin_II , and aldosterone in hypertensive disease of pregnancy .
4156503	0	renin	7,12	angiotensin_II	43,57	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nmod|blockade blockade|nmod|END_ENTITY	Plasma renin response to acute blockade of angiotensin_II in the anaesthetized rat .
429480	0	renin	71,76	angiotensin_II	35,49	renin	angiotensin II	5972	183	Gene	Gene	hypertension|amod|START_ENTITY patients|nmod|hypertension END_ENTITY|nmod|patients	Enhanced adrenal responsiveness to angiotensin_II in patients with low renin essential hypertension .
4331508	0	renin	11,16	angiotensin_II	60,74	renin	angiotensin II	5972	183	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|effect effect|nmod|END_ENTITY	Release of renin by human kidney slices , in vitro effect of angiotensin_II , norepinephrine and aldosterone .
4373995	0	renin	29,34	angiotensin_II	72,86	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY correlation|nmod|activity correlation|nmod|END_ENTITY	A correlation between plasma renin activity and the pressor response to angiotensin_II .
613577	0	renin	15,20	angiotensin_II	47,61	renin	angiotensin II	5972	183	Gene	Gene	START_ENTITY|nmod|blockade blockade|amod|END_ENTITY	-LSB- Hemodynamics , renin and aldosterone following angiotensin_II blockade and sodium_chloride deficiency in hypertensive subjects -RSB- .
618602	0	renin	11,16	angiotensin_II	32,46	renin	angiotensin II	5972	183	Gene	Gene	Failure|nmod|START_ENTITY suppression|nsubj|Failure suppression|nmod|END_ENTITY	Failure of renin suppression by angiotensin_II in hypertension .
6400371	0	renin	43,48	angiotensin_II	11,25	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY reduce|dobj|activity Failure|acl|reduce Failure|nmod|END_ENTITY	Failure of angiotensin_II to reduce plasma renin activity in hypertensive pregnant women .
6400372	0	renin	131,136	angiotensin_II	52,66	renin	angiotensin II	5972	183	Gene	Gene	ratio|compound|START_ENTITY determining|dobj|ratio factors|acl|determining secretion|dep|factors secretion|nmod|END_ENTITY	Renal secretion of inactive renin and extraction of angiotensin_II in renal_artery_stenosis in man : factors determining renal vein renin ratio .
6400372	0	renin	28,33	angiotensin_II	52,66	renin	angiotensin II	5972	183	Gene	Gene	secretion|nmod|START_ENTITY secretion|nmod|END_ENTITY	Renal secretion of inactive renin and extraction of angiotensin_II in renal_artery_stenosis in man : factors determining renal vein renin ratio .
657448	0	renin	60,65	angiotensin_II	24,38	renin	angiotensin II	5972	183	Gene	Gene	hypertension|amod|START_ENTITY patients|nmod|hypertension response|nmod|patients response|nmod|END_ENTITY	The pressor response to angiotensin_II in patients with low renin essential hypertension .
6756705	0	renin	27,32	angiotensin_II	59,73	renin	angiotensin II	5972	183	Gene	Gene	START_ENTITY|nmod|infusion infusion|nmod|END_ENTITY	Plasma active and inactive renin in man during infusion of angiotensin_II with and without prior administration of nifedipine .
7018685	0	renin	74,79	angiotensin_II	44,58	renin	angiotensin II	5972	183	Gene	Gene	subgroups|compound|START_ENTITY effects|nmod|subgroups effects|appos|analog analog|amod|END_ENTITY	Hemodynamic effects of -LSB- Sar1 , Ile8 -RSB- AII , an angiotensin_II analog , in the renin subgroups of essential hypertension .
7047005	0	renin	91,96	angiotensin_II	30,44	renin	angiotensin II	5972	183	Gene	Gene	hypertension|amod|START_ENTITY subjects|nmod|hypertension END_ENTITY|nmod|subjects	Aldosterone responsiveness to angiotensin_II after sodium restriction in subjects with low renin essential hypertension .
7584907	0	renin	69,74	angiotensin_II	38,52	renin	angiotensin II	5972	183	Gene	Gene	substrates|amod|START_ENTITY generate|nmod|substrates generate|dobj|END_ENTITY	Human urinary kallikrein can generate angiotensin_II from homologous renin substrates .
7644529	0	renin	21,26	angiotensin_II	103,117	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression counteracted|nsubjpass|stimulation counteracted|nmod|END_ENTITY	Tonic stimulation of renin gene expression by nitric_oxide is counteracted by tonic inhibition through angiotensin_II .
7659950	0	renin	63,68	angiotensin_II	33,47	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|ZENECA_ZD8731 ZENECA_ZD8731|appos|antagonist antagonist|amod|END_ENTITY	The effects of ZENECA_ZD8731 , an angiotensin_II antagonist , on renin expression by juxtaglomerular cells in the rat : comparison of protein and mRNA expression as detected by immunohistochemistry and in situ hybridization .
7759857	0	renin	34,39	angiotensin_II	125,139	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY depletion|nmod|levels depletion|dep|evidence evidence|nmod|stimulation stimulation|nmod|angiotensinogen angiotensinogen|nmod|END_ENTITY	Angiotensinogen depletion by high renin levels in hypertensive rats : no evidence for tonic stimulation of angiotensinogen by angiotensin_II .
7922810	0	renin	8,13	angiotensin_II	30,44	renin	angiotensin II	5972	183	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	-LSB- Plasma renin activity -LRB- PRA -RRB- , angiotensin_II -LRB- AII -RRB- , atrial natriuretic peptide -LRB- ANP -RRB- and AII/ANP ratio in severely burned patients -RSB- .
8031544	0	renin	19,24	angiotensin_II	53,67	renin	angiotensin II	5972	183	Gene	Gene	inhibitor|compound|START_ENTITY R-PEP-27|appos|inhibitor decreases|nsubj|R-PEP-27 decreases|dobj|END_ENTITY	R-PEP-27 , a potent renin inhibitor , decreases plasma angiotensin_II and blood pressure in normal volunteers .
8456103	0	renin	134,139	angiotensin_II	33,47	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	actions|nmod|START_ENTITY drinking|dobj|actions Effect|acl|drinking Effect|appos|antagonist antagonist|amod|END_ENTITY	Effect of Losartan , a nonpeptide angiotensin_II receptor antagonist , on drinking behavior and renal actions of centrally administered renin .
8833654	0	renin	147,152	angiotensin_II	35,49	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	loop|compound|START_ENTITY mechanism|nmod|loop factor|dep|mechanism mediated|nmod|factor mediated|nsubjpass|activation activation|nmod|END_ENTITY	Angiotensinogen gene activation by angiotensin_II is mediated by the rel_A -LRB- nuclear factor-kappaB p65 -RRB- transcription factor : one mechanism for the renin angiotensin system positive feedback loop in hepatocytes .
886656	0	renin	78,83	angiotensin_II	110,124	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nmod|antagonist antagonist|amod|END_ENTITY	Role of renin-angiotensin system in experimental hypertension in rats : plasma renin and hypotensive effect of angiotensin_II antagonist .
9136670	0	renin	54,59	angiotensin_II	12,26	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	The role of angiotensin_II in the feedback control of renin gene expression .
9226634	0	renin	7,12	angiotensin_II	54,68	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|dobj|rate rate|nmod|END_ENTITY	Plasma renin activity and metabolic clearance rate of angiotensin_II in the unstressed aging rat .
9431853	0	renin	54,59	angiotensin_II	70,84	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	system|compound|START_ENTITY stimulation|nmod|system Role|nmod|stimulation Role|nmod|blockade blockade|amod|END_ENTITY	Role of sympathetic nerves for the stimulation of the renin system by angiotensin_II receptor blockade .
9440700	0	renin	58,63	angiotensin_II	6,20	renin	angiotensin II	24715(Tax:10116)	24179(Tax:10116)	Gene	Gene	uptake|compound|START_ENTITY role|nmod|uptake generation|dep|role generation|compound|END_ENTITY	Local angiotensin_II generation in the rat heart : role of renin uptake .
9740600	0	renin	125,130	angiotensin_II	13,27	renin	angiotensin II	5972	183	Gene	Gene	system|compound|START_ENTITY interruption|nmod|system evidence|nmod|interruption Pathways|dep|evidence Pathways|nmod|generation generation|amod|END_ENTITY	Pathways for angiotensin_II generation in intact human tissue : evidence from comparative pharmacological interruption of the renin system .
1847704	0	renin	129,134	angiotensin_converting_enzyme	22,51	renin	angiotensin converting enzyme	5972	1636	Gene	Gene	response|compound|START_ENTITY enhances|dobj|response enhances|nsubj|Effects Effects|nmod|changes changes|nmod|activity activity|amod|END_ENTITY	Effects of changes in angiotensin_converting_enzyme activity on renin release : pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects .
1847704	0	renin	64,69	angiotensin_converting_enzyme	22,51	renin	angiotensin converting enzyme	5972	1636	Gene	Gene	release|compound|START_ENTITY activity|nmod|release activity|amod|END_ENTITY	Effects of changes in angiotensin_converting_enzyme activity on renin release : pretreatment with dexamethasone enhances a plasma renin activity response to captopril in normal subjects .
21169387	0	renin	7,12	angiotensin_converting_enzyme	63,92	renin	angiotensin converting enzyme	5972	1636	Gene	Gene	START_ENTITY|acl|inhibition inhibition|xcomp|END_ENTITY	Direct renin inhibition in addition to or as an alternative to angiotensin_converting_enzyme inhibition in patients with chronic systolic heart_failure : rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart_failuRE -LRB- ATMOSPHERE -RRB- study .
24175935	0	renin	65,70	angiotensin_converting_enzyme	24,53	renin	angiotensin converting enzyme	100054248(Tax:9796)	100064801(Tax:9796)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Effects of quinapril on angiotensin_converting_enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite , quinaprilat , after intravenous and oral administration to mature horses .
2666614	0	renin	57,62	angiotensin_converting_enzyme	94,123	renin	angiotensin converting enzyme	403838(Tax:9615)	610668(Tax:9615)	Gene	Gene	inhibition|compound|START_ENTITY action|nmod|inhibition lowering|dobj|action lowering|nmod|inhibition inhibition|amod|END_ENTITY	Characteristics of the blood pressure lowering action of renin inhibition and comparison with angiotensin_converting_enzyme inhibition .
7910063	0	renin	114,119	angiotensin_converting_enzyme	27,56	renin	angiotensin converting enzyme	5972	1636	Gene	Gene	status|compound|START_ENTITY relation|nmod|status response|dep|relation response|nmod|inhibitor inhibitor|amod|END_ENTITY	Blood pressure response to angiotensin_converting_enzyme inhibitor in essential hypertension : its relation to the renin status and natriuresis during acute sodium loading .
8845072	0	renin	34,39	angiotensin_converting_enzyme	98,127	renin	angiotensin converting enzyme	24715(Tax:10116)	24310(Tax:10116)	Gene	Gene	level|compound|START_ENTITY Reversal|nmod|level Reversal|nmod|inhibition inhibition|amod|END_ENTITY	Reversal of the suppressed kidney renin level in the hypertensive transgenic rat TGR -LRB- mRen-2 -RRB- 27 by angiotensin_converting_enzyme inhibition .
9231029	0	renin	11,16	angiotensin_converting_enzyme	40,69	renin	angiotensin converting enzyme	403838(Tax:9615)	610668(Tax:9615)	Gene	Gene	inhibition|compound|START_ENTITY Effects|nmod|inhibition compared|nsubj|Effects compared|xcomp|END_ENTITY	Effects of renin inhibition compared to angiotensin_converting_enzyme inhibition in conscious dogs with pacing-induced heart_failure .
11230308	0	renin	47,52	angiotensin_ii	66,80	renin	angiotensin ii	5972	183	Gene	Gene	regulation|nmod|START_ENTITY transgene|nsubj|regulation transgene|nmod|END_ENTITY	Paradoxical regulation of short promoter human renin transgene by angiotensin_ii .
12037697	0	renin	23,28	angiotensinogen	66,81	renin	angiotensinogen	5972	183	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Heritability of plasma renin activity and plasma concentration of angiotensinogen and angiotensin-converting_enzyme .
15775783	0	renin	90,95	angiotensinogen	24,39	renin	angiotensinogen	5972	183	Gene	Gene	function|nmod|START_ENTITY Significance|nmod|function Significance|nmod|END_ENTITY	Significance of urinary angiotensinogen in essential hypertension as a function of plasma renin and aldosterone status .
1583541	0	renin	78,83	angiotensinogen	55,70	renin	angiotensinogen	5972	183	Gene	Gene	START_ENTITY|nsubj|simulation simulation|nmod|behaviour behaviour|nmod|END_ENTITY	Computer simulation of the conformational behaviour of angiotensinogen -LRB- 6-13 -RRB- renin substrate .
15942685	0	renin	96,101	angiotensinogen	54,69	renin	angiotensinogen	5972	183	Gene	Gene	reaction|nmod|START_ENTITY Roles|nmod|reaction Roles|nmod|END_ENTITY	Roles of His9 -LRB- P2 subsite -RRB- and His13 -LRB- P3 ' subsite -RRB- in angiotensinogen for catalytic reaction of renin .
16109805	0	renin	71,76	angiotensinogen	27,42	renin	angiotensinogen	5972	11606(Tax:10090)	Gene	Gene	transgenic_mice|compound|START_ENTITY pressure|nmod|transgenic_mice lowers|dobj|pressure lowers|nsubj|ablation ablation|nmod|END_ENTITY	Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic_mice .
17261087	0	renin	98,103	angiotensinogen	25,40	renin	angiotensinogen	5972	183	Gene	Gene	specificity|nmod|START_ENTITY determinant|nmod|specificity determinant|nsubj|motif motif|nmod|END_ENTITY	The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin .
1812721	0	renin	148,153	angiotensinogen	37,52	renin	angiotensinogen	5972	183	Gene	Gene	inhibitors|nmod|START_ENTITY discovery|nmod|inhibitors END_ENTITY|nmod|discovery	Exploiting the molecular template of angiotensinogen in the discovery and design of peptidyl , pseudopeptidyl and peptidimimetic inhibitors of human renin : a structure-activity perspective .
1824738	0	renin	123,128	angiotensinogen	4,19	renin	angiotensinogen	5972	183	Gene	Gene	measurements|compound|START_ENTITY implications|nmod|measurements severity|dep|implications related|nmod|severity related|nsubjpass|levels levels|compound|END_ENTITY	Low angiotensinogen levels are related to the severity and liver_dysfunction of congestive_heart_failure : implications for renin measurements .
1856110	0	renin	12,17	angiotensinogen	19,34	renin	angiotensinogen	5972	183	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of renin , angiotensinogen , angiotensin_II in the lamb anterior pituitary gland : immunocytochemical study after cryoultramicrotomy .
19303904	0	renin	88,93	angiotensinogen	50,65	renin	angiotensinogen	5972	183	Gene	Gene	reduces|dobj|START_ENTITY reduces|nsubj|exposure exposure|nmod|cells cells|nmod|renin renin|nmod|END_ENTITY	Prolonged exposure of cardiac cells to renin plus angiotensinogen reduces intracellular renin in the failing heart .
2016704	0	renin	29,34	angiotensinogen	198,213	renin	angiotensinogen	5972	183	Gene	Gene	peptides|compound|START_ENTITY peptides|dep|carboxymethyl carboxymethyl|dep|L-prolyl-L-phenylalanyl-L-histidinamide L-prolyl-L-phenylalanyl-L-histidinamide|nmod|restriction restriction|nmod|portion portion|nmod|template template|compound|END_ENTITY	Conformationally constrained renin inhibitory peptides : cyclic _ -LRB- 3-1 -RRB- -1 - -LRB- carboxymethyl -RRB- - L-prolyl-L-phenylalanyl-L-histidinamide as a conformational restriction at the P2-P4 tripeptide portion of the angiotensinogen template .
2085885	0	renin	19,24	angiotensinogen	46,61	renin	angiotensinogen	5972	183	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|dep|containing containing|nsubj|analogs analogs|amod|END_ENTITY	Synthesis of human renin inhibitory peptides , angiotensinogen transition-state analogs containing a retro-inverso_amide bond .
2120440	0	renin	20,25	angiotensinogen	50,65	renin	angiotensinogen	5972	183	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|acl|derived derived|nmod|state state|amod|END_ENTITY	Orally potent human renin inhibitors derived from angiotensinogen transition state : design , synthesis , and mode of interaction .
22026939	0	renin	14,19	angiotensinogen	49,64	renin	angiotensinogen	5972	183	Gene	Gene	activity|compound|START_ENTITY activity|nmod|analogues analogues|amod|END_ENTITY	Synthesis and renin inhibitory activity of novel angiotensinogen transition state analogues modified at the P -LRB- 2 -RRB- - histidine position .
2407641	0	renin	117,122	angiotensinogen	43,58	renin	angiotensinogen	5972	183	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene Assignment|dobj|region Assignment|nmod|hybridization hybridization|nmod|gene gene|compound|END_ENTITY	Assignment by in situ hybridization of the angiotensinogen gene to chromosome band 1q4 , the same region as the human renin gene .
24154707	0	renin	110,115	angiotensinogen	116,131	renin	angiotensinogen	5972	183	Gene	Gene	transgenic_mice|compound|START_ENTITY transgenic_mice|compound|END_ENTITY	Renin inhibition ameliorates renal damage through prominent suppression of both angiotensin_I and II in human renin angiotensinogen transgenic_mice with high salt loading .
3275468	0	renin	138,143	angiotensinogen	71,86	renin	angiotensinogen	5972	183	Gene	Gene	influence|nmod|START_ENTITY influence|nsubj|residues residues|nmod|side side|nmod|site site|nmod|END_ENTITY	The amino-acid residues on the C-terminal side of the cleavage site of angiotensinogen influence the species specificity of reaction with renin .
3290486	0	renin	14,19	angiotensinogen	43,58	renin	angiotensinogen	5972	183	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Synthesis and renin inhibitory activity of angiotensinogen analogues having dehydrostatine , Leu psi -LSB- CH2S -RSB- Val , or Leu psi -LSB- CH2SO -RSB- Val at the P1-P1 ' cleavage site .
3314712	0	renin	75,80	angiotensinogen	14,29	renin	angiotensinogen	5972	183	Gene	Gene	substrates|nmod|START_ENTITY Comparison|nmod|substrates Comparison|nmod|END_ENTITY	Comparison of angiotensinogen and tetradecapeptide as substrates for human renin .
3514748	0	renin	21,26	angiotensinogen	3,18	renin	angiotensinogen	5972	183	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nsubj|END_ENTITY	Is angiotensinogen a renin inhibitor and not the substrate for renin ?
3912982	0	renin	14,19	angiotensinogen	31,46	renin	angiotensinogen	5972	183	Gene	Gene	substrate|compound|START_ENTITY Evidence|dep|substrate Evidence|appos|END_ENTITY	Evidence that renin substrate -LRB- angiotensinogen -RRB- may be a precursor of erythropoietin .
6159648	0	renin	23,28	angiotensinogen	35,50	renin	angiotensinogen	5972	183	Gene	Gene	START_ENTITY|nmod|analog analog|compound|END_ENTITY	Specific inhibition of renin by an angiotensinogen analog : studies in sodium depletion and renin-dependent hypertension .
6352942	0	renin	14,19	angiotensinogen	23,38	renin	angiotensinogen	5972	183	Gene	Gene	START_ENTITY|nmod|peptide peptide|compound|END_ENTITY	Inhibition of renin by angiotensinogen peptide fragments containing the hydroxy_amino_acid residue 5-amino-3-hydroxy-7-methyloctanoic_acid .
6380499	0	renin	57,62	angiotensinogen	26,41	renin	angiotensinogen	5972	183	Gene	Gene	activity|amod|START_ENTITY analogues|nmod|activity analogues|nsubj|aspects aspects|nmod|END_ENTITY	Conformational aspects of angiotensinogen analogues with renin inhibitory activity .
6385771	0	renin	161,166	angiotensinogen	68,83	renin	angiotensinogen	5972	183	Gene	Gene	specific|compound|START_ENTITY END_ENTITY|acl:relcl|specific	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
6385771	0	renin	33,38	angiotensinogen	68,83	renin	angiotensinogen	5972	183	Gene	Gene	cleavage|nmod|START_ENTITY substrate|nsubj|cleavage substrate|xcomp|analogous analogous|nmod|END_ENTITY	Renin cleavage of a human kidney renin substrate analogous to human angiotensinogen , H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Ser-OH , that is human renin specific and is resistant to cathepsin_D .
6751323	0	renin	14,19	angiotensinogen	64,79	renin	angiotensinogen	5972	183	Gene	Gene	START_ENTITY|nmod|analogues analogues|nmod|END_ENTITY	Inhibition of renin by conformationally restricted analogues of angiotensinogen .
7635534	0	renin	17,22	angiotensinogen	71,86	renin	angiotensinogen	5972	183	Gene	Gene	Effects|nmod|START_ENTITY Effects|amod|transgenic transgenic|nmod|END_ENTITY	Effects of human renin in the vasculature of rats transgenic for human angiotensinogen .
9095095	0	renin	22,27	angiotensinogen	57,72	renin	angiotensinogen	5972	183	Gene	Gene	effects|nmod|START_ENTITY effects|amod|transgenic transgenic|nmod|END_ENTITY	Dose effects of human renin in rats transgenic for human angiotensinogen .
9757569	0	renin	93,98	angiotensinogen	64,79	renin	angiotensinogen	5972	183	Gene	Gene	reaction|compound|START_ENTITY END_ENTITY|nmod|reaction	Effects of glycosylation of the residue at position 14 in ovine angiotensinogen on the human renin reaction .
9931123	0	renin	26,31	angiotensinogen	78,93	renin	angiotensinogen	5972	183	Gene	Gene	pressure|compound|START_ENTITY pressure|nmod|END_ENTITY	Appropriate regulation of renin and blood pressure in 45-kb human renin/human angiotensinogen transgenic_mice .
9972250	0	renin	69,74	angiotensinogen	50,65	renin	angiotensinogen	5972	183	Gene	Gene	activity|compound|START_ENTITY Effects|nmod|activity Effects|nmod|Val_for_Leu11 Val_for_Leu11|nmod|END_ENTITY	Effects of substitution of Val_for_Leu11 of ovine angiotensinogen on renin activity .
19851787	0	renin	91,96	antidiuretic_hormone	30,50	renin	antidiuretic hormone	5972	551	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Influence of season on plasma antidiuretic_hormone , angiotensin_II , aldosterone and plasma renin activity in young volunteers .
6368208	0	renin	67,72	antidiuretic_hormone	7,27	renin	antidiuretic hormone	5972	551	Gene	Gene	hypertension|amod|START_ENTITY END_ENTITY|nmod|hypertension	Plasma antidiuretic_hormone levels in patients with normal and low renin essential hypertension , and secondary hypertension .
10555096	0	renin	14,19	atrial_natriuretic_factor	33,58	renin	atrial natriuretic factor	403838(Tax:9615)	608289(Tax:9615)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Modulation of renin secretion by atrial_natriuretic_factor prohormone fragment 31-67 .
1438145	0	renin	48,53	atrial_natriuretic_factor	11,36	renin	atrial natriuretic factor	403838(Tax:9615)	608289(Tax:9615)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Changes in atrial_natriuretic_factor and plasma renin activity in dogs infected with Trypanosoma_brucei .
2148294	0	renin	82,87	atrial_natriuretic_factor	55,80	renin	atrial natriuretic factor	5972	4878	Gene	Gene	activity|amod|START_ENTITY Relationship|dobj|activity Relationship|nmod|END_ENTITY	Relationship between natriuresis and changes in plasma atrial_natriuretic_factor , renin activity and aldosterone levels in fasting obese subjects .
2473345	0	renin	39,44	atrial_natriuretic_factor	10,35	renin	atrial natriuretic factor	24715(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on renin and aldosterone .
2522364	0	renin	75,80	atrial_natriuretic_factor	38,63	renin	atrial natriuretic factor	403838(Tax:9615)	608289(Tax:9615)	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Effects of hypoxia and hypercapnia on atrial_natriuretic_factor and plasma renin activity in conscious dogs .
2546456	0	renin	27,32	atrial_natriuretic_factor	60,85	renin	atrial natriuretic factor	403838(Tax:9615)	608289(Tax:9615)	Gene	Gene	response|compound|START_ENTITY inhibition|nmod|response Mechanism|nmod|inhibition Mechanism|acl|hypotension hypotension|nmod|END_ENTITY	Mechanism of inhibition of renin response to hypotension by atrial_natriuretic_factor .
2856722	0	renin	39,44	atrial_natriuretic_factor	10,35	renin	atrial natriuretic factor	403838(Tax:9615)	608289(Tax:9615)	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_factor on renin secretion , plasma renin and aldosterone in dogs with acute unilateral renal artery constriction .
2941270	0	renin	37,42	atrial_natriuretic_factor	8,33	renin	atrial natriuretic factor	24715(Tax:10116)	24602(Tax:10116)	Gene	Gene	release|compound|START_ENTITY Role|nmod|release Role|nmod|END_ENTITY	Role of atrial_natriuretic_factor in renin release .
2941371	0	renin	36,41	atrial_natriuretic_factor	55,80	renin	atrial natriuretic factor	403838(Tax:9615)	608289(Tax:9615)	Gene	Gene	suppression|nmod|START_ENTITY mechanisms|nmod|suppression secretion|nsubj|mechanisms secretion|nmod|END_ENTITY	Renal mechanisms for suppression of renin secretion by atrial_natriuretic_factor .
2945679	0	renin	98,103	atrial_natriuretic_factor	30,55	renin	atrial natriuretic factor	24715(Tax:10116)	24602(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY Effect|appos|activity Effect|nmod|infusion infusion|nmod|END_ENTITY	Effect of chronic infusion of atrial_natriuretic_factor on plasma and urinary aldosterone , plasma renin activity , blood pressure and sodium excretion in 2-K , 1-C hypertensive rats .
2977168	0	renin	154,159	atrial_natriuretic_factor	19,44	renin	atrial natriuretic factor	5972	4878	Gene	Gene	activity|compound|START_ENTITY effect|nmod|activity Increase|dep|effect Increase|nmod|END_ENTITY	Increase in plasma atrial_natriuretic_factor and right atrial area during endogenous and exogenous volume loading in healthy volunteers : effect on plasma renin activity , aldosterone and antidiuretic_hormone .
2990872	0	renin	70,75	atrial_natriuretic_factor	14,39	renin	atrial natriuretic factor	24715(Tax:10116)	24602(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY inhibits|nmod|secretion inhibits|nsubj|END_ENTITY	Synthetic rat atrial_natriuretic_factor inhibits in vitro and in vivo renin secretion in rats .
3015641	0	renin	41,46	atrial_natriuretic_factor	4,29	renin	atrial natriuretic factor	24715(Tax:10116)	24602(Tax:10116)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Rat atrial_natriuretic_factor stimulates renin release from renal cortical slices .
2166655	0	renin	48,53	atrial_natriuretic_peptide	10,36	renin	atrial natriuretic peptide	24715(Tax:10116)	24602(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of atrial_natriuretic_peptide on adrenal renin and aldosterone .
3156142	0	renin	33,38	beta-Endorphin	0,14	renin	beta-Endorphin	5972	5443	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	beta-Endorphin stimulates plasma renin and aldosterone release in normal human subjects .
2853751	0	renin	15,20	beta_1-adrenoceptor	78,97	renin	beta 1-adrenoceptor	5972	153	Gene	Gene	Stimulation|nmod|START_ENTITY Stimulation|dep|role role|nmod|END_ENTITY	Stimulation of renin by blockade of alpha 2-adrenoceptors in man : role of the beta_1-adrenoceptor .
3023226	0	renin	7,12	beta_1-adrenoceptor	88,107	renin	beta 1-adrenoceptor	5972	153	Gene	Gene	START_ENTITY|nmod|blockade blockade|amod|END_ENTITY	Plasma renin activity , active and inactive renin concentrations , and their responses to beta_1-adrenoceptor blockade with metoprolol in hyperthyroidism .
1864303	0	renin	40,45	brain_natriuretic_peptide	11,36	renin	brain natriuretic peptide	403838(Tax:9615)	487441(Tax:9615)	Gene	Gene	secretion|compound|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of brain_natriuretic_peptide on renin secretion in normal and hypertonic saline-infused kidney .
9690204	0	renin	53,58	c-Jun	17,22	renin	c-Jun	5972	16476(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY role|nmod|gene role|nmod|END_ENTITY	Possible role of c-Jun in transcription of the mouse renin gene .
10564233	0	renin	38,43	cyclooxygenase-2	85,101	renin	cyclooxygenase-2	5972	5743	Gene	Gene	Inhibition|nmod|START_ENTITY secretion|nsubj|Inhibition secretion|nmod|blockade blockade|nmod|END_ENTITY	Inhibition of macula densa-stimulated renin secretion by pharmacological blockade of cyclooxygenase-2 .
10954003	0	renin	65,70	cyclooxygenase-2	8,24	renin	cyclooxygenase-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	blunts|dobj|START_ENTITY blunts|nsubj|inhibition inhibition|amod|END_ENTITY	Chronic cyclooxygenase-2 inhibition blunts low sodium-stimulated renin without changing renal haemodynamics .
11316844	0	renin	96,101	cyclooxygenase-2	21,37	renin	cyclooxygenase-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY resistance|nmod|secretion resistance|amod|END_ENTITY	Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion .
11680616	0	renin	95,100	cyclooxygenase-2	14,30	renin	cyclooxygenase-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY affecting|dobj|expression prostanoid_excretion|advcl|affecting prostanoid_excretion|nsubj|Inhibition Inhibition|nmod|attenuates attenuates|amod|END_ENTITY	Inhibition of cyclooxygenase-2 attenuates urinary prostanoid_excretion without affecting renal renin expression .
12434137	0	renin	67,72	cyclooxygenase-2	11,27	renin	cyclooxygenase-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Effects of cyclooxygenase-2 -LRB- COX-2 -RRB- inhibition on plasma and renal renin in diabetes .
12456386	0	renin	43,48	cyclooxygenase-2	14,30	renin	cyclooxygenase-2	443310(Tax:9940)	443460(Tax:9940)	Gene	Gene	secretion|compound|START_ENTITY effects|nmod|secretion Inhibition|dep|effects Inhibition|nmod|END_ENTITY	Inhibition of cyclooxygenase-2 : effects on renin secretion and expression in fetal lambs .
19861503	0	renin	112,117	cyclooxygenase-2	58,74	renin	cyclooxygenase-2	24715(Tax:10116)	29527(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Glucose promotes the production of interleukine-1beta and cyclooxygenase-2 in mesangial cells via enhanced -LRB- Pro -RRB- renin receptor expression .
1738400	0	renin	41,46	erythropoietin	16,30	renin	erythropoietin	5972	2056	Gene	Gene	activity|compound|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Acute effect of erythropoietin on plasma renin activity and aldosterone levels in end-stage_renal_disease .
989773	0	renin	10,15	erythropoietin	30,44	renin	erythropoietin	24715(Tax:10116)	24335(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|production production|compound|END_ENTITY	Effect of renin on extrarenal erythropoietin production .
10831629	0	renin	35,40	growth_hormone	11,25	renin	growth hormone	24715(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of growth_hormone on renal renin gene expression in normal rats and rats with myocardial_infarction .
19673942	0	renin	127,132	inducible_nitric_oxide_synthase	52,83	renin	inducible nitric oxide synthase	5972	18126(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cellular expression of renal , cardiac and pulmonary inducible_nitric_oxide_synthase in double-transgenic_mice expressing human renin and angiotensinogen genes .
12715277	0	renin	55,60	insulin_and_insulin-like_growth_factor-I	11,51	renin	insulin and insulin-like growth factor-I	5972	3630	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of insulin_and_insulin-like_growth_factor-I on renin gene expression in the renal cortical cells of ovine fetuses .
2087934	0	renin	7,12	kallikrein	34,44	renin	kallikrein	5972	9622	Gene	Gene	START_ENTITY|dobj|excretion excretion|compound|END_ENTITY	Plasma renin activity and urinary kallikrein excretion in response to intravenous furosemide in diabetic patients .
2676859	0	renin	62,67	kallikrein	35,45	renin	kallikrein	5972	9622	Gene	Gene	hypertension|amod|START_ENTITY activity|nmod|hypertension activity|compound|END_ENTITY	Mechanisms of suppression of renal kallikrein activity in low renin essential hypertension and renoparenchymal hypertension .
6432545	0	renin	150,155	kallikrein	43,53	renin	kallikrein	5972	9622	Gene	Gene	relation|nmod|START_ENTITY measurement|dep|relation measurement|nmod|excretion excretion|compound|END_ENTITY	Direct and indirect measurement of urinary kallikrein excretion in patients with essential hypertension and normotensives : relation to age and plasma renin and aldosterone levels .
7007236	0	renin	84,89	kallikrein	17,27	renin	kallikrein	5972	9622	Gene	Gene	activity|compound|START_ENTITY related|nmod|activity related|nsubjpass|END_ENTITY	Abnormal urinary kallikrein in hypertension is not related to aldosterone or plasma renin activity .
7008062	0	renin	72,77	kallikrein	11,21	renin	kallikrein	5972	9622	Gene	Gene	plasma|dobj|START_ENTITY plasma|nsubj|renin renin|dep|END_ENTITY	The renin -- kallikrein -- prostaglandin system : plasma active and inactive renin and urinary kallikrein during prostacyclin infusion in man .
7021413	0	renin	32,37	kallikrein	47,57	renin	kallikrein	5972	9622	Gene	Gene	acid-activation|nmod|START_ENTITY Mechanism|nmod|acid-activation Mechanism|dep|role role|nmod|END_ENTITY	Mechanism of acid-activation of renin : role of kallikrein in renin activation .
7021413	0	renin	61,66	kallikrein	47,57	renin	kallikrein	5972	9622	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|nmod|activation	Mechanism of acid-activation of renin : role of kallikrein in renin activation .
7037811	0	renin	40,45	kallikrein	69,79	renin	kallikrein	5972	9622	Gene	Gene	Responses|nmod|START_ENTITY Responses|nmod|END_ENTITY	Responses of active and inactive plasma renin and changes in urinary kallikrein and plasma prekallikrein to various conditions in normal subjects .
7584907	0	renin	69,74	kallikrein	14,24	renin	kallikrein	5972	9622	Gene	Gene	substrates|amod|START_ENTITY generate|nmod|substrates generate|nsubj|END_ENTITY	Human urinary kallikrein can generate angiotensin_II from homologous renin substrates .
912848	0	renin	29,34	kallikrein	8,18	renin	kallikrein	5972	9622	Gene	Gene	hypertension|amod|START_ENTITY END_ENTITY|nmod|hypertension	Urinary kallikrein in normal renin essential hypertension .
1325309	0	renin	50,55	neuropeptide_Y	21,35	renin	neuropeptide Y	24715(Tax:10116)	24604(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY effect|nmod|secretion effect|nmod|END_ENTITY	Inhibitory effect of neuropeptide_Y on stimulated renin secretion of awake rats .
24423297	0	renin	22,27	parathyroid_hormone	64,83	renin	parathyroid hormone	5972	5741	Gene	Gene	ratio|compound|START_ENTITY aldosterone|nmod|ratio associated|nsubjpass|aldosterone associated|nmod|concentrations concentrations|compound|END_ENTITY	A high aldosterone to renin ratio is associated with high serum parathyroid_hormone concentrations in the general population .
24979301	0	renin	101,106	parathyroid_hormone	60,79	renin	parathyroid hormone	24715(Tax:10116)	24694(Tax:10116)	Gene	Gene	increase|nmod|START_ENTITY increase|amod|END_ENTITY	High phosphate diet increases arterial blood pressure via a parathyroid_hormone mediated increase of renin .
426073	0	renin	40,45	parathyroid_hormone	10,29	renin	parathyroid hormone	280909(Tax:9913)	280903(Tax:9913)	Gene	Gene	activity|compound|START_ENTITY Effect|nmod|activity Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on plasma renin activity and sodium excretion .
6342000	0	renin	33,38	parathyroid_hormone	10,29	renin	parathyroid hormone	280909(Tax:9913)	280903(Tax:9913)	Gene	Gene	secretion|compound|START_ENTITY Effect|nmod|secretion Effect|nmod|END_ENTITY	Effect of parathyroid_hormone on renin secretion .
8382128	0	renin	45,50	parathyroid_hormone	22,41	renin	parathyroid hormone	24715(Tax:10116)	24694(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY END_ENTITY|nmod|secretion	Stimulatory action of parathyroid_hormone on renin secretion in vitro : a study using isolated rat kidney , isolated rabbit glomeruli and superfused dispersed rat juxtaglomerular cells .
19273273	0	renin	32,37	peptide_YY	2,12	renin	peptide YY	5972	5697	Gene	Gene	activity|compound|START_ENTITY inhibits|dobj|activity inhibits|nsubj|END_ENTITY	A peptide_YY inhibits the human renin activity in a pH dependent manner .
19741056	0	renin	48,53	phosphodiesterase_1C	18,38	renin	phosphodiesterase 1C	5972	5137	Gene	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Calcium-dependent phosphodiesterase_1C inhibits renin release from isolated juxtaglomerular cells .
15076197	0	renin	27,32	renin	7,12	renin	renin	5972	5972	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	Active renin versus plasma renin activity to define aldosterone-to-renin ratio for primary_aldosteronism .
15076197	0	renin	7,12	renin	27,32	renin	renin	5972	5972	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Active renin versus plasma renin activity to define aldosterone-to-renin ratio for primary_aldosteronism .
1655341	0	renin	35,40	renin	7,12	renin	renin	5972	5972	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Kidney renin gene expression after renin inhibition in the marmoset .
1655341	0	renin	7,12	renin	35,40	renin	renin	5972	5972	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Kidney renin gene expression after renin inhibition in the marmoset .
18698213	0	renin	26,31	renin	46,51	renin	renin	5972	5972	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Prorenin engages the -LRB- pro -RRB- renin receptor like renin and both ligand activities are unopposed by aliskiren .
18698213	0	renin	46,51	renin	26,31	renin	renin	5972	5972	Gene	Gene	receptor|nmod|START_ENTITY receptor|compound|END_ENTITY	Prorenin engages the -LRB- pro -RRB- renin receptor like renin and both ligand activities are unopposed by aliskiren .
19893565	0	renin	16,21	renin	29,34	renin	renin	5972	5972	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	The increase in renin during renin inhibition : does it result in harmful effects by the -LRB- pro -RRB- renin receptor ?
19893565	0	renin	29,34	renin	16,21	renin	renin	5972	5972	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	The increase in renin during renin inhibition : does it result in harmful effects by the -LRB- pro -RRB- renin receptor ?
2412015	0	renin	53,58	renin	75,80	renin	renin	5972	5972	Gene	Gene	START_ENTITY|nmod|inhibitor inhibitor|compound|END_ENTITY	In vitro and in vivo inhibition of human and primate renin by a new potent renin inhibitor : SR_42128 .
2412015	0	renin	75,80	renin	53,58	renin	renin	5972	5972	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|nmod|inhibitor	In vitro and in vivo inhibition of human and primate renin by a new potent renin inhibitor : SR_42128 .
2987126	0	renin	17,22	renin	30,35	renin	renin	5972	5972	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Increased plasma renin during renin inhibition .
2987126	0	renin	30,35	renin	17,22	renin	renin	5972	5972	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Increased plasma renin during renin inhibition .
3282115	0	renin	51,56	renin	92,97	renin	renin	5972	5972	Gene	Gene	START_ENTITY|nmod|levels levels|nmod|END_ENTITY	-LSB- Correlation of the total activity of blood plasma renin with levels of active and inactive renin , angiotensinogen and angiotensin_II under different functional loads in patients with hypertension -RSB- .
3282115	0	renin	92,97	renin	51,56	renin	renin	5972	5972	Gene	Gene	levels|nmod|START_ENTITY END_ENTITY|nmod|levels	-LSB- Correlation of the total activity of blood plasma renin with levels of active and inactive renin , angiotensinogen and angiotensin_II under different functional loads in patients with hypertension -RSB- .
3905453	0	renin	43,48	renin	80,85	renin	renin	5972	5972	Gene	Gene	characterization|nmod|START_ENTITY END_ENTITY|nsubj|characterization	Electrophoretic characterization of active renin from human kidney and inactive renin from a human chorionic cell culture .
3905453	0	renin	80,85	renin	43,48	renin	renin	5972	5972	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Electrophoretic characterization of active renin from human kidney and inactive renin from a human chorionic cell culture .
4119172	0	renin	14,19	renin	7,12	renin	renin	5972	5972	Gene	Gene	substrate|compound|START_ENTITY END_ENTITY|appos|substrate	Plasma renin , renin substrate , angiotensin_II , and aldosterone in hypertensive disease of pregnancy .
4119172	0	renin	7,12	renin	14,19	renin	renin	5972	5972	Gene	Gene	START_ENTITY|appos|substrate substrate|compound|END_ENTITY	Plasma renin , renin substrate , angiotensin_II , and aldosterone in hypertensive disease of pregnancy .
6400372	0	renin	131,136	renin	28,33	renin	renin	5972	5972	Gene	Gene	ratio|compound|START_ENTITY determining|dobj|ratio factors|acl|determining secretion|dep|factors secretion|nmod|END_ENTITY	Renal secretion of inactive renin and extraction of angiotensin_II in renal_artery_stenosis in man : factors determining renal vein renin ratio .
6400372	0	renin	28,33	renin	131,136	renin	renin	5972	5972	Gene	Gene	secretion|nmod|START_ENTITY secretion|dep|factors factors|acl|determining determining|dobj|ratio ratio|compound|END_ENTITY	Renal secretion of inactive renin and extraction of angiotensin_II in renal_artery_stenosis in man : factors determining renal vein renin ratio .
747665	0	renin	19,24	renin	51,56	renin	renin	403838(Tax:9615)	403838(Tax:9615)	Gene	Gene	Conversion|nmod|START_ENTITY END_ENTITY|nsubj|Conversion	Conversion between renin and high-molecular-weight renin in the dog .
747665	0	renin	51,56	renin	19,24	renin	renin	403838(Tax:9615)	403838(Tax:9615)	Gene	Gene	START_ENTITY|nsubj|Conversion Conversion|nmod|END_ENTITY	Conversion between renin and high-molecular-weight renin in the dog .
7814847	0	renin	102,107	renin	111,116	renin	renin	24715(Tax:10116)	24715(Tax:10116)	Gene	Gene	START_ENTITY|nmod|inhibitors inhibitors|compound|END_ENTITY	Identification of vascular renin-binding proteins by chemical cross-linking : inhibition of binding of renin by renin inhibitors .
7814847	0	renin	111,116	renin	102,107	renin	renin	24715(Tax:10116)	24715(Tax:10116)	Gene	Gene	inhibitors|compound|START_ENTITY END_ENTITY|nmod|inhibitors	Identification of vascular renin-binding proteins by chemical cross-linking : inhibition of binding of renin by renin inhibitors .
9719044	0	renin	32,37	renin	83,88	renin	renin	5972	5972	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Appropriate regulation of human renin gene expression and secretion in 45-kb human renin transgenic_mice .
9719044	0	renin	83,88	renin	32,37	renin	renin	5972	5972	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Appropriate regulation of human renin gene expression and secretion in 45-kb human renin transgenic_mice .
1587805	0	renin	124,129	renin-binding_protein	40,61	renin	renin-binding protein	5972	19703(Tax:10090)	Gene	Gene	transfected|nmod|START_ENTITY transfected|nsubj|Modulation Modulation|nmod|secretion secretion|nmod|END_ENTITY	Modulation of active renin secretion by renin-binding_protein -LRB- RnBP -RRB- in mouse pituitary AtT-20 cells transfected with human renin and RnBP cDNAs .
1587805	0	renin	21,26	renin-binding_protein	40,61	renin	renin-binding protein	5972	19703(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|END_ENTITY	Modulation of active renin secretion by renin-binding_protein -LRB- RnBP -RRB- in mouse pituitary AtT-20 cells transfected with human renin and RnBP cDNAs .
7028749	0	renin	69,74	renin-binding_protein	16,37	renin	renin-binding protein	5972	5973	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nsubj|END_ENTITY	A 56,000-dalton renin-binding_protein in hog kidney is an endogenous renin inhibitor .
2872161	0	renin	36,41	vasopressin	17,28	renin	vasopressin	5972	551	Gene	Gene	hypertension|amod|START_ENTITY END_ENTITY|nmod|hypertension	Increased plasma vasopressin in low renin essential hypertension .
3513487	0	renin	82,87	vasopressin	49,60	renin	vasopressin	5972	551	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Cardiovascular haemodynamics and the response of vasopressin , aldosterone , plasma renin activity and plasma catecholamines to head-up tilt in young and old healthy subjects .
6367368	0	renin	60,65	vasopressin	17,28	renin	vasopressin	5972	551	Gene	Gene	type|compound|START_ENTITY uric_acid|nmod|type uric_acid|nsubj|END_ENTITY	Increased plasma vasopressin and serum uric_acid in the low renin type of essential hypertension .
11098137	0	renin-binding_protein	51,72	Renin	0,5	renin-binding protein	Renin	5973	5972	Gene	Gene	2-epimerase|appos|START_ENTITY inhibits|dobj|2-epimerase inhibits|nsubj|END_ENTITY	Renin inhibits N-acetyl-D-glucosamine 2-epimerase -LRB- renin-binding_protein -RRB- .
1587805	0	renin-binding_protein	40,61	renin	124,129	renin-binding protein	renin	19703(Tax:10090)	5972	Gene	Gene	secretion|nmod|START_ENTITY Modulation|nmod|secretion transfected|nsubj|Modulation transfected|nmod|END_ENTITY	Modulation of active renin secretion by renin-binding_protein -LRB- RnBP -RRB- in mouse pituitary AtT-20 cells transfected with human renin and RnBP cDNAs .
1587805	0	renin-binding_protein	40,61	renin	21,26	renin-binding protein	renin	19703(Tax:10090)	5972	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Modulation of active renin secretion by renin-binding_protein -LRB- RnBP -RRB- in mouse pituitary AtT-20 cells transfected with human renin and RnBP cDNAs .
7028749	0	renin-binding_protein	16,37	renin	69,74	renin-binding protein	renin	5973	5972	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|compound|END_ENTITY	A 56,000-dalton renin-binding_protein in hog kidney is an endogenous renin inhibitor .
6274571	0	renin_and_angiotensin_II	23,47	ACTH	0,4	renin and angiotensin II	ACTH	5972;183	5443	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	ACTH stimulates plasma renin_and_angiotensin_II in man .
3924907	0	renin_binding_protein	11,32	RnBP	34,38	renin binding protein	RnBP	5973	5973	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A study on renin_binding_protein -LRB- RnBP -RRB- in the human kidney .
15479830	0	rep	57,60	PCNA	0,4	rep	PCNA	991136(Tax:33726)	5111	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	PCNA interacts with Indian mung_bean_yellow_mosaic_virus rep and downregulates Rep activity .
17981954	0	replication_protein_A	12,33	RPA	35,38	replication protein A	RPA	6117	6117	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of replication_protein_A -LRB- RPA -RRB- in human spermatogenesis .
12077133	0	replication_protein_A	30,51	Rad52	0,5	replication protein A	Rad52	6117	5893	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Rad52 protein associates with replication_protein_A -LRB- RPA -RRB- - single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation .
7876167	0	replication_protein_A	29,50	XPA	19,22	replication protein A	XPA	6117	7507	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	DNA repair protein XPA binds replication_protein_A -LRB- RPA -RRB- .
22684010	0	replication_protein_A2	71,93	4E-BP3	0,6	replication protein A2	4E-BP3	6118	8637	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	4E-BP3 regulates eIF4E-mediated nuclear mRNA export and interacts with replication_protein_A2 .
10336450	0	replication_protein_A_middle_subunit	19,55	RPA32	57,62	replication protein A middle subunit	RPA32	6118	6118	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of replication_protein_A_middle_subunit -LRB- RPA32 -RRB- leads to a disassembly of the RPA heterotrimer .
14643653	0	repressor_element_1-silencing_transcription_factor	19,69	REST	71,75	repressor element 1-silencing transcription factor	REST	5978	5978	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of the repressor_element_1-silencing_transcription_factor -LRB- REST -RRB- with target genes .
23233483	0	reptin	23,29	ATPase	4,10	reptin	ATPase	10856	1769	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	The ATPase activity of reptin is required for its effects on tumor cell growth and viability_in_hepatocellular_carcinoma .
25085051	0	repulsive_guidance_molecule_b	14,43	RGMb	45,49	repulsive guidance molecule b	RGMb	681433(Tax:10116)	681433(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of repulsive_guidance_molecule_b -LRB- RGMb -RRB- in the uterus and ovary during the estrous cycle in rats .
24424064	0	resistin	24,32	Endothelin-1	0,12	resistin	Endothelin-1	56729	1906	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Endothelin-1 stimulates resistin gene expression .
14602788	0	resistin	6,14	FIZZ3	16,21	resistin	FIZZ3	56729	56729	Gene	Gene	protein|amod|START_ENTITY protein|compound|END_ENTITY	Serum resistin -LRB- FIZZ3 -RRB- protein is increased in obese humans .
24465803	0	resistin	26,34	Heparanase	0,10	resistin	Heparanase	56729	10855	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Heparanase interacts with resistin and augments its activity .
15585589	0	resistin	20,28	IGF-I	0,5	resistin	IGF-I	56729	3479	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	IGF-I downregulates resistin gene expression and protein secretion .
11444881	0	resistin	58,66	Insulin	0,7	resistin	Insulin	56729	3630	Gene	Gene	related|xcomp|START_ENTITY related|nsubjpass|resistance resistance|compound|END_ENTITY	Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle .
12627322	0	resistin	114,122	Insulin	0,7	resistin	Insulin	56729	3630	Gene	Gene	mRNA|compound|START_ENTITY degradation|nmod|mRNA accelerate|dobj|degradation protein|acl:relcl|accelerate synthesis|nmod|protein down-regulates|nmod|synthesis down-regulates|nsubj|END_ENTITY	Insulin down-regulates resistin mRNA through the synthesis of protein -LRB- s -RRB- that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes .
12627322	0	resistin	23,31	Insulin	0,7	resistin	Insulin	56729	3630	Gene	Gene	mRNA|compound|START_ENTITY down-regulates|dobj|mRNA down-regulates|nsubj|END_ENTITY	Insulin down-regulates resistin mRNA through the synthesis of protein -LRB- s -RRB- that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes .
17107342	0	resistin	71,79	Oct-2	17,22	resistin	Oct-2	57264(Tax:10090)	18987(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A novel role for Oct-2 in the lipopolysaccharide-mediated induction of resistin gene expression in RAW264 .7 cells .
11558907	0	resistin	39,47	RSTN	49,53	resistin	RSTN	57264(Tax:10090)	57264(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms of the resistin -LRB- RSTN -RRB- gene .
22493735	0	resistin	15,23	Sirt1	0,5	resistin	Sirt1	56729	23411	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Sirt1 inhibits resistin expression in aortic_stenosis .
11689013	0	resistin	55,63	Tumor_necrosis_factor_alpha	0,27	resistin	Tumor necrosis factor alpha	56729	7124	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes .
16914597	0	resistin	32,40	adiponectin	19,30	resistin	adiponectin	56729	9370	Gene	Gene	interleukin_6|dep|START_ENTITY interleukin_6|compound|END_ENTITY	Normative data for adiponectin , resistin , interleukin_6 , and leptin/receptor ratio in a healthy Spanish pediatric population : relationship with sex steroids .
18583069	0	resistin	16,24	adiponectin	50,61	resistin	adiponectin	56729	9370	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Serum levels of resistin and its correlation with adiponectin and insulin in healthy full term neonates .
22944288	0	resistin	19,27	adiponectin	6,17	resistin	adiponectin	56729	9370	Gene	Gene	concentration|dep|START_ENTITY concentration|compound|END_ENTITY	Serum adiponectin , resistin , leptin concentration and central adiposity parameters in Barrett 's _ esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD .
26376464	0	resistin	79,87	adiponectin	45,56	resistin	adiponectin	56729	9370	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Liraglutide treatment causes upregulation of adiponectin and downregulation of resistin in Chinese_type_2_diabetes .
25677700	0	resistin	21,29	cystatin_C	35,45	resistin	cystatin C	56729	1471	Gene	Gene	START_ENTITY|nmod|ratio ratio|amod|END_ENTITY	Association of serum resistin with cystatin_C and urinary albumin-to-creatinine ratio in elderly Chinese men with essential hypertension .
12050208	0	resistin	6,14	insulin	75,82	resistin	insulin	56729	3630	Gene	Gene	gene|compound|START_ENTITY gene|dep|scanning scanning|nmod|association association|nmod|sensitivity sensitivity|compound|END_ENTITY	Human resistin gene : molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians .
12829623	0	resistin	58,66	insulin	76,83	resistin	insulin	56729	3630	Gene	Gene	link|dobj|START_ENTITY link|nmod|resistance resistance|compound|END_ENTITY	A promoter genotype and oxidative stress potentially link resistin to human insulin resistance .
12830457	0	resistin	10,18	insulin	56,63	resistin	insulin	56729	3630	Gene	Gene	levels|compound|START_ENTITY associated|nsubjpass|levels associated|nmod|resistance resistance|compound|END_ENTITY	Increased resistin blood levels are not associated with insulin resistance in patients with renal_disease .
14671216	0	resistin	44,52	insulin	67,74	resistin	insulin	56729	3630	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Resistin and type 2 diabetes : regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes .
16625816	0	resistin	12,20	insulin	40,47	resistin	insulin	56729	3630	Gene	Gene	role|nmod|START_ENTITY role|nmod|resistance resistance|compound|END_ENTITY	The role of resistin in obesity-induced insulin resistance .
17445546	0	resistin	6,14	insulin	40,47	resistin	insulin	56729	3630	Gene	Gene	level|compound|START_ENTITY associated|nsubjpass|level associated|nmod|sensitivity sensitivity|compound|END_ENTITY	Serum resistin level is associated with insulin sensitivity in Japanese patients with type_2_diabetes_mellitus .
20113417	0	resistin	21,29	insulin	53,60	resistin	insulin	56729	3630	Gene	Gene	levels|amod|START_ENTITY Relationship|nmod|levels Relationship|nmod|resistance resistance|compound|END_ENTITY	Relationship between resistin and aPAI-1 levels with insulin resistance in Saudi children .
22866969	0	resistin	7,15	insulin	43,50	resistin	insulin	56729	3630	Gene	Gene	levels|compound|START_ENTITY associated|nsubjpass|levels associated|nmod|resistance resistance|compound|END_ENTITY	Plasma resistin levels are associated with insulin resistance in older Japanese men from a rural village .
23178185	0	resistin	15,23	insulin	48,55	resistin	insulin	56729	3630	Gene	Gene	gene|compound|START_ENTITY Association|nmod|gene polymorphisms|nsubj|Association polymorphisms|nmod|resistance resistance|compound|END_ENTITY	Association of resistin gene polymorphisms with insulin resistance in Egyptian_obese patients .
16227702	0	resistin	144,152	resistin	49,57	resistin	resistin	56729	56729	Gene	Gene	levels|compound|START_ENTITY Effect|nmod|levels Effect|nmod|END_ENTITY	Effect of atorvastatin on in vitro expression of resistin in adipocytes and monocytes/macrophages and effect of atorvastatin treatment on serum resistin levels in patients with type 2 diabetes .
16227702	0	resistin	49,57	resistin	144,152	resistin	resistin	56729	56729	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of atorvastatin on in vitro expression of resistin in adipocytes and monocytes/macrophages and effect of atorvastatin treatment on serum resistin levels in patients with type 2 diabetes .
26256230	0	resistin	28,36	resistin	59,67	resistin	resistin	100142685(Tax:9685)	100142685(Tax:9685)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of feline resistin and the expression of resistin , leptin , and adiponectin in the adipose tissue of normal and obese cats .
26256230	0	resistin	59,67	resistin	28,36	resistin	resistin	100142685(Tax:9685)	100142685(Tax:9685)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of feline resistin and the expression of resistin , leptin , and adiponectin in the adipose tissue of normal and obese cats .
16116950	0	resistin	41,49	tumor_necrosis_factor-alpha	10,37	resistin	tumor necrosis factor-alpha	56729	7124	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha on resistin expression in 3T3-L1 adipocytes and its mechanism .
23069678	0	rest	14,18	NCX1	0,4	rest	NCX1	5978	6546	Gene	Gene	gene|compound|START_ENTITY gene|nsubj|END_ENTITY	NCX1 is a new rest target gene : role in cerebral_ischemia .
17393088	0	restin	32,38	p53	42,45	restin	p53	28986	7157	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|nmod|END_ENTITY	Transcriptional upregulation of restin by p53 .
12701883	0	ret	101,104	GFR_alpha_1	67,78	ret	GFR alpha 1	19713(Tax:10090)	14585(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Internalization of glial cell-derived neurotrophic factor receptor GFR_alpha_1 in the absence of the ret tyrosine kinase coreceptor .
10465268	0	ret	53,56	shc	84,87	ret	shc	5979	6464	Gene	Gene	START_ENTITY|nmod|specific specific|nmod|domain domain|amod|END_ENTITY	The role of amino_acids surrounding tyrosine 1062 in ret in specific binding of the shc phosphotyrosine-binding domain .
11850190	0	ret_finger_protein-like_4	4,29	Rfpl4	36,41	ret finger protein-like 4	Rfpl4	192658(Tax:10090)	192658(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The ret_finger_protein-like_4 gene , Rfpl4 , encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells .
18561328	0	reticulocalbin_1	28,44	TNF-alpha	119,128	reticulocalbin 1	TNF-alpha	5954	7124	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Novel surface expression of reticulocalbin_1 on bone endothelial cells and human prostate_cancer cells is regulated by TNF-alpha .
18561328	0	reticulocalbin_1	28,44	TNF-alpha	119,128	reticulocalbin 1	TNF-alpha	5954	7124	Gene	Gene	expression|nmod|START_ENTITY regulated|nsubjpass|expression regulated|nmod|END_ENTITY	Novel surface expression of reticulocalbin_1 on bone endothelial cells and human prostate_cancer cells is regulated by TNF-alpha .
14986927	0	reticulon_3	24,35	hRTN3	37,42	reticulon 3	hRTN3	10313	10313	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of human reticulon_3 -LRB- hRTN3 -RRB- in astrocytoma .
9514702	0	retinal_S-antigen	57,74	IL-4	100,104	retinal S-antigen	IL-4	25539(Tax:10116)	287287(Tax:10116)	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Regulatory cells generated by testicular tolerization to retinal_S-antigen : possible involvement of IL-4 , IL-10 , and TGF-beta in the suppression of experimental autoimmune uveoretinitis .
7914867	0	retinal_degeneration_B	140,162	rdgB	169,173	retinal degeneration B	rdgB	32340(Tax:7227)	32340(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of the gene encoding human phosphatidylinositol transfer protein -LRB- PITPN -RRB- to 17p13 .3 : a gene showing homology to the Drosophila retinal_degeneration_B gene -LRB- rdgB -RRB- .
8112464	0	retinal_degeneration_slow	37,62	NGF1-A	22,28	retinal degeneration slow	NGF1-A	19133(Tax:10090)	13653(Tax:10090)	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Diurnal expression of NGF1-A mRNA in retinal_degeneration_slow -LRB- rds -RRB- mutant mouse retina .
23650562	0	retinal_degeneration_slow	18,43	RDS	45,48	retinal degeneration slow	RDS	19133(Tax:10090)	19133(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Overexpression of retinal_degeneration_slow -LRB- RDS -RRB- protein adversely affects rods in the rd7 model of enhanced_S-cone_syndrome .
8485576	0	retinal_degeneration_slow	23,48	RDS	50,53	retinal degeneration slow	RDS	5961	5961	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mutations in the human retinal_degeneration_slow -LRB- RDS -RRB- gene can cause either retinitis_pigmentosa or macular_dystrophy .
8112464	0	retinal_degeneration_slow	37,62	rds	64,67	retinal degeneration slow	rds	19133(Tax:10090)	19133(Tax:10090)	Gene	Gene	mRNA|nmod|START_ENTITY expression|nmod|mRNA expression|appos|END_ENTITY	Diurnal expression of NGF1-A mRNA in retinal_degeneration_slow -LRB- rds -RRB- mutant mouse retina .
24788806	0	retinal_dehydrogenase_2	45,68	RALDH2	70,76	retinal dehydrogenase 2	RALDH2	19378(Tax:10090)	19378(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Retinoic_acid and GM-CSF coordinately induce retinal_dehydrogenase_2 -LRB- RALDH2 -RRB- expression through cooperation between the RAR/RXR complex and Sp1 in dendritic cells .
11983430	0	retinal_dehydrogenase_type-2	26,54	RALDH2	56,62	retinal dehydrogenase type-2	RALDH2	19378(Tax:10090)	19378(Tax:10090)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Kinetic analysis of mouse retinal_dehydrogenase_type-2 -LRB- RALDH2 -RRB- for retinal substrates .
10783262	0	retinal_fascin	26,40	FSCN2	47,52	retinal fascin	FSCN2	337926(Tax:9913)	25794	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of human retinal_fascin gene -LRB- FSCN2 -RRB- at 17q25 : close physical linkage of fascin and cytoplasmic actin genes .
16460036	0	retinal_guanylate_cyclase	59,84	rhodopsin	12,21	retinal guanylate cyclase	rhodopsin	3000	6010	Gene	Gene	activation|nmod|START_ENTITY required|nmod|activation required|nsubjpass|END_ENTITY	Illuminated rhodopsin is required for strong activation of retinal_guanylate_cyclase by guanylate cyclase-activating proteins .
22451137	0	retinal_short-chain_dehydrogenase_reductase	16,59	RDHE2	61,66	retinal short-chain dehydrogenase reductase	RDHE2	525500(Tax:9913)	525500(Tax:9913)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Major effect of retinal_short-chain_dehydrogenase_reductase -LRB- RDHE2 -RRB- on bovine fat colour .
9106168	0	retinaldehyde_dehydrogenase_type_2	70,104	RALDH-2	106,113	retinaldehyde dehydrogenase type 2	RALDH-2	19378(Tax:10090)	19378(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Restricted expression and retinoic_acid-induced downregulation of the retinaldehyde_dehydrogenase_type_2 -LRB- RALDH-2 -RRB- gene during mouse development .
11960024	0	retinitis_pigmentosa-1	135,157	Rp1	159,162	retinitis pigmentosa-1	Rp1	19888(Tax:10090)	19888(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Progressive photoreceptor_degeneration , outer_segment_dysplasia , and rhodopsin mislocalization in mice with targeted disruption of the retinitis_pigmentosa-1 -LRB- Rp1 -RRB- gene .
12724644	0	retinitis_pigmentosa_1	63,85	RP1	87,90	retinitis pigmentosa 1	RP1	6101	6101	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of RP1L1 , a highly polymorphic paralog of the retinitis_pigmentosa_1 -LRB- RP1 -RRB- gene .
12634863	0	retinitis_pigmentosa_1-like1	43,71	RP1L1	78,83	retinitis pigmentosa 1-like1	RP1L1	94137	94137	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification and characterisation of the retinitis_pigmentosa_1-like1 gene -LRB- RP1L1 -RRB- : a novel candidate for retinal_degenerations .
21282572	0	retinitis_pigmentosa_2	43,65	RP2	67,70	retinitis pigmentosa 2	RP2	406755(Tax:7955)	406755(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Knockdown of the zebrafish ortholog of the retinitis_pigmentosa_2 -LRB- RP2 -RRB- gene results in retinal_degeneration .
21738648	0	retinitis_pigmentosa_2	23,45	RP2	47,50	retinitis pigmentosa 2	RP2	6102	6102	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Functional analysis of retinitis_pigmentosa_2 -LRB- RP2 -RRB- protein reveals variable pathogenic potential of disease-associated missense variants .
26383048	0	retinitis_pigmentosa_2	8,30	RP2	32,35	retinitis pigmentosa 2	RP2	19889(Tax:10090)	19889(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Loss of retinitis_pigmentosa_2 -LRB- RP2 -RRB- protein affects cone photoreceptor sensory cilium elongation in mice .
20200501	0	retinitis_pigmentosa_GTPase_regulator_interacting_protein_1	4,63	RPGR	80,84	retinitis pigmentosa GTPase regulator interacting protein 1	RPGR	568018(Tax:7955)	571327(Tax:7955)	Gene	Gene	links|nsubj|START_ENTITY links|dobj|END_ENTITY	The retinitis_pigmentosa_GTPase_regulator_interacting_protein_1 -LRB- RPGRIP1 -RRB- links RPGR to the nephronophthisis protein network .
8649843	0	retinoblastoma	18,32	Bcl-3	52,57	retinoblastoma	Bcl-3	5925	602	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Activation of the retinoblastoma gene expression by Bcl-3 : implication for muscle cell differentiation .
19190782	0	retinoblastoma	40,54	KIF14	0,5	retinoblastoma	KIF14	5925	9928	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association .
7970718	0	retinoblastoma	13,27	MyoD	0,4	retinoblastoma	MyoD	5925	4654	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	MyoD induces retinoblastoma gene expression during myogenic differentiation .
8528059	0	retinoblastoma	4,18	RB-1	25,29	retinoblastoma	RB-1	5925	5925	Gene	Gene	status|compound|START_ENTITY status|appos|END_ENTITY	The retinoblastoma gene -LRB- RB-1 -RRB- status in multiple_myeloma : a report on 35 cases .
14660307	0	retinoblastoma	26,40	RB1	47,50	retinoblastoma	RB1	5925	5925	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Methylation status of the retinoblastoma gene -LRB- RB1 -RRB- in osteosarcoma : no evidence for hypermethylation .
26208635	0	retinoblastoma	15,29	Rbf1	39,43	retinoblastoma	Rbf1	31027(Tax:7227)	31027(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Drosophila retinoblastoma protein , Rbf1 , induces a debcl and drp1-dependent mitochondrial apoptosis .
26208635	0	retinoblastoma	15,29	Rbf1	39,43	retinoblastoma	Rbf1	31027(Tax:7227)	31027(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The Drosophila retinoblastoma protein , Rbf1 , induces a debcl and drp1-dependent mitochondrial apoptosis .
1565477	0	retinoblastoma	56,70	Transforming_growth_factor_beta_1	0,33	retinoblastoma	Transforming growth factor beta 1	5925	7040	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- inhibits retinoblastoma gene expression but not pRB phosphorylation in TGF-beta_1-growth stimulated colon_carcinoma cells .
8674005	0	retinoblastoma	15,29	p16	36,39	retinoblastoma	p16	5925	1029	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of retinoblastoma , p53 , p16 -LRB- CDKN2 -RRB- , and p15 genes in human astrocytomas .
12847100	0	retinoblastoma	112,126	p21Cip1	82,89	retinoblastoma	p21Cip1	5925	1026	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein .
8674005	0	retinoblastoma	15,29	p53	31,34	retinoblastoma	p53	5925	7157	Gene	Gene	Alterations|nmod|START_ENTITY Alterations|appos|END_ENTITY	Alterations of retinoblastoma , p53 , p16 -LRB- CDKN2 -RRB- , and p15 genes in human astrocytomas .
8759895	0	retinoblastoma	4,18	rb1	25,28	retinoblastoma	rb1	5925	5925	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The retinoblastoma gene -LRB- rb1 -RRB- in acute_myeloid_leukaemia : analysis of gene rearrangements , protein expression and comparison of disease outcome .
16873370	0	retinoblastoma-binding_protein_1	53,85	RBBP1	87,92	retinoblastoma-binding protein 1	RBBP1	5926	5926	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Estrogen receptor isoform-specific regulation of the retinoblastoma-binding_protein_1 -LRB- RBBP1 -RRB- gene : roles of AF1 and enhancer elements .
8031579	0	retinoblastoma_1	26,42	RB1	49,52	retinoblastoma 1	RB1	19645(Tax:10090)	19645(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal assignment of retinoblastoma_1 gene -LRB- RB1 -RRB- to mouse 14D3 and rat 15q12 by fluorescence in situ hybridization .
24068189	0	retinoblastoma_binding_protein_2	20,52	a-smooth_muscle_actin	81,102	retinoblastoma binding protein 2	a-smooth muscle actin	5927	58	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|nmod|END_ENTITY	Histone demethylase retinoblastoma_binding_protein_2 regulates the expression of a-smooth_muscle_actin and vimentin in cirrhotic livers .
21676486	0	retinoblastoma_binding_protein_6	27,59	RBBP6	61,66	retinoblastoma binding protein 6	RBBP6	5930	5930	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of retinoblastoma_binding_protein_6 -LRB- RBBP6 -RRB- in human lung_cancer .
11135439	0	retinoblastoma_protein_interacting_zinc_finger	9,55	RIZ	0,3	retinoblastoma protein interacting zinc finger	RIZ	7799	7799	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	RIZ , the retinoblastoma_protein_interacting_zinc_finger gene , is mutated in genetically unstable cancers of the pancreas , stomach , and colorectum .
7925417	0	retinoic-acid-induced-heparin-binding	42,79	RIHB	81,85	retinoic-acid-induced-heparin-binding	RIHB	423196(Tax:9031)	423196(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Organisation and promoter activity of the retinoic-acid-induced-heparin-binding -LRB- RIHB -RRB- gene .
15370293	0	retinoic_acid-inducible_gene-I	25,55	Interferon-gamma	0,16	retinoic acid-inducible gene-I	Interferon-gamma	23586	3458	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interferon-gamma induces retinoic_acid-inducible_gene-I in endothelial cells .
16210631	0	retinoic_acid-inducible_gene-I	79,109	Lgp2	17,21	retinoic acid-inducible gene-I	Lgp2	230073(Tax:10090)	80861(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic_acid-inducible_gene-I .
17182220	0	retinoic_acid-inducible_gene-I	23,53	RIG-I	55,60	retinoic acid-inducible gene-I	RIG-I	23586	23586	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Cytokine modulation of retinoic_acid-inducible_gene-I -LRB- RIG-I -RRB- expression in human epidermal keratinocytes .
22391244	0	retinoic_acid-inducible_gene-I	20,50	RIG-I	52,57	retinoic acid-inducible gene-I	RIG-I	23586	23586	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Characterization of retinoic_acid-inducible_gene-I -LRB- RIG-I -RRB- expression corresponding to viral_infection and UVB in human keratinocytes .
19126414	0	retinoic_acid-inducible_gene-I	36,66	Tumor-necrosis_factor-alpha	0,27	retinoic acid-inducible gene-I	Tumor-necrosis factor-alpha	23586	7124	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Tumor-necrosis_factor-alpha induces retinoic_acid-inducible_gene-I in rheumatoid fibroblast-like synoviocytes .
15219805	0	retinoic_acid-inducible_gene-I	14,44	interferon-gamma	93,109	retinoic acid-inducible gene-I	interferon-gamma	23586	3458	Gene	Gene	Expression|nmod|START_ENTITY stimulated|nsubj|Expression stimulated|nmod|END_ENTITY	Expression of retinoic_acid-inducible_gene-I in vascular smooth muscle cells stimulated with interferon-gamma .
15297736	0	retinoic_acid-inducible_gene-I	16,46	interferon-gamma	102,118	retinoic acid-inducible gene-I	interferon-gamma	23586	3458	Gene	Gene	Upregulation|nmod|START_ENTITY stimulated|nsubj|Upregulation stimulated|nmod|END_ENTITY	Upregulation of retinoic_acid-inducible_gene-I in T24 urinary_bladder_carcinoma cells stimulated with interferon-gamma .
11994980	0	retinoic_acid_4-hydroxylase	61,88	CYP26	90,95	retinoic acid 4-hydroxylase	CYP26	1592	1592	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	all-trans-Retinoic_acid-induced expression and regulation of retinoic_acid_4-hydroxylase -LRB- CYP26 -RRB- in human promyelocytic_leukemia .
25900241	0	retinoic_acid_induced_16	50,74	heat_shock_protein_70	103,124	retinoic acid induced 16	heat shock protein 70	64760	3308	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Anchoring of both PKA-RIIa and 14-3-3 regulates retinoic_acid_induced_16 mediated phosphorylation of heat_shock_protein_70 .
17516545	0	retinoic_acid_inducible_gene-I	70,100	IRF-1	48,53	retinoic acid inducible gene-I	IRF-1	23586	3659	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Central role of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in controlling retinoic_acid_inducible_gene-I -LRB- RIG-I -RRB- expression .
17516545	0	retinoic_acid_inducible_gene-I	70,100	interferon_regulatory_factor-1	16,46	retinoic acid inducible gene-I	interferon regulatory factor-1	23586	3659	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Central role of interferon_regulatory_factor-1 -LRB- IRF-1 -RRB- in controlling retinoic_acid_inducible_gene-I -LRB- RIG-I -RRB- expression .
8149483	0	retinoic_acid_nuclear_receptors	77,108	Retinoic_acid_nuclear_receptors	0,31	retinoic acid nuclear receptors	Retinoic acid nuclear receptors	19401(Tax:10090)	19401(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Retinoic_acid_nuclear_receptors and tumor promotion : decreased expression of retinoic_acid_nuclear_receptors by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate .
21053424	0	retinoic_acid_receptor	62,84	Tribbles_homolog_1	6,24	retinoic acid receptor	Tribbles homolog 1	5914	10221	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Human Tribbles_homolog_1 functions as a negative regulator of retinoic_acid_receptor .
19799861	0	retinoic_acid_receptor	48,70	thioredoxin_glutathione_reductase	74,107	retinoic acid receptor	thioredoxin glutathione reductase	19401(Tax:10090)	232223(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Redox regulation of transcriptional activity of retinoic_acid_receptor by thioredoxin_glutathione_reductase -LRB- TGR -RRB- .
16805833	0	retinoic_acid_receptor	54,76	tyrosine_hydroxylase	14,34	retinoic acid receptor	tyrosine hydroxylase	5914	7054	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of tyrosine_hydroxylase gene expression by retinoic_acid_receptor .
10976918	0	retinoic_acid_receptor-alpha	40,68	AF-1	4,8	retinoic acid receptor-alpha	AF-1	5914	3460	Gene	Gene	domains|nmod|START_ENTITY domains|amod|END_ENTITY	The AF-1 and AF-2 activating domains of retinoic_acid_receptor-alpha -LRB- RARalpha -RRB- and their phosphorylation are differentially involved in parietal endodermal differentiation of F9 cells and retinoid-induced expression of target genes .
15613498	0	retinoic_acid_receptor-alpha	74,102	VEGF	31,35	retinoic acid receptor-alpha	VEGF	534280(Tax:9913)	281572(Tax:9913)	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|expression expression|amod|END_ENTITY	Visible light exposure induces VEGF gene expression through activation of retinoic_acid_receptor-alpha in retinoblastoma Y79 cells .
19596122	0	retinoic_acid_receptor-alpha	19,47	corticotropin-releasing_hormone	51,82	retinoic acid receptor-alpha	corticotropin-releasing hormone	5914	1392	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|expression expression|amod|END_ENTITY	The involvement of retinoic_acid_receptor-alpha in corticotropin-releasing_hormone gene expression and affective_disorders .
10969805	0	retinoic_acid_receptor-alpha	13,41	granulocyte_macrophage_colony-stimulating_factor	45,93	retinoic acid receptor-alpha	granulocyte macrophage colony-stimulating factor	5914	1437	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of retinoic_acid_receptor-alpha by granulocyte_macrophage_colony-stimulating_factor in human myeloid_leukemia cell lines .
12076325	0	retinoic_acid_receptor-beta	4,31	RAR-beta	33,41	retinoic acid receptor-beta	RAR-beta	5915	5915	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The retinoic_acid_receptor-beta -LRB- RAR-beta -RRB- mRNA expression in the oral_squamous_cell_carcinoma associated with betel quid use .
17608728	0	retinoic_acid_receptor-beta	145,172	tumor-suppressor	173,189	retinoic acid receptor-beta	tumor-suppressor	5915	7248	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The DNA-binding epidermal_growth_factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic_acid_receptor-beta tumor-suppressor gene in breast_cancer cells .
20332535	0	retinoic_acid_receptor-related_orphan_receptor_alpha	48,100	FGF21	14,19	retinoic acid receptor-related orphan receptor alpha	FGF21	6095	26291	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of FGF21 expression and secretion by retinoic_acid_receptor-related_orphan_receptor_alpha .
25300573	0	retinoic_acid_receptor_alpha	23,51	RARA	53,57	retinoic acid receptor alpha	RARA	5914	5914	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of retinoic_acid_receptor_alpha -LRB- RARA -RRB- induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures .
10192433	0	retinoic_acid_receptor_alpha	19,47	RAR_alpha	49,58	retinoic acid receptor alpha	RAR alpha	5914	5914	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alterations of the retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- gene in myeloid and lymphoid_malignancies .
9387294	0	retinoic_acid_receptor_alpha	88,116	RAR_alpha	118,127	retinoic acid receptor alpha	RAR alpha	5914	5914	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	-LSB- Growth inhibitory effect of retinoic_acid in human breast_cancer cells correlates with retinoic_acid_receptor_alpha -LRB- RAR_alpha -RRB- expression -RSB- .
10397747	0	retinoic_acid_receptor_alpha	28,56	RARalpha	58,66	retinoic acid receptor alpha	RARalpha	19401(Tax:10090)	19401(Tax:10090)	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of wild-type retinoic_acid_receptor_alpha -LRB- RARalpha -RRB- recapitulates retinoic_acid-sensitive transformation of primary myeloid progenitors by acute_promyelocytic_leukemia RARalpha-fusion genes .
9434940	0	retinoic_acid_receptor_alpha	58,86	Rara	88,92	retinoic acid receptor alpha	Rara	19401(Tax:10090)	19401(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A new mutation Rim3 resembling Re -LRB- den -RRB- is mapped close to retinoic_acid_receptor_alpha -LRB- Rara -RRB- gene on mouse chromosome 11 .
8912864	0	retinoic_acid_receptor_alpha	24,52	estrogen	65,73	retinoic acid receptor alpha	RARalpha	5914	5914	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Regulation of the human retinoic_acid_receptor_alpha gene in the estrogen receptor negative human breast_carcinoma cell lines SKBR-3 and MDA-MB-435 .
26969398	0	retinoic_acid_receptor_alpha	47,75	vitamin_D_receptor	14,32	retinoic acid receptor alpha	vitamin D receptor	5914	7421	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of vitamin_D_receptor expression by retinoic_acid_receptor_alpha in acute_myeloid_leukemia cells .
21319187	0	retinoic_acid_receptor_b	32,56	Nur77	14,19	retinoic acid receptor b	Nur77	5915	3164	Gene	Gene	mediated|nmod|START_ENTITY END_ENTITY|acl|mediated	Enrichment of Nur77 mediated by retinoic_acid_receptor_b leads to apoptosis of human hepatocellular_carcinoma cells induced by fenretinide and histone deacetylase inhibitors .
17804711	0	retinoic_acid_receptor_beta	34,61	HOXA5	0,5	retinoic acid receptor beta	HOXA5	5915	3202	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	HOXA5 acts directly downstream of retinoic_acid_receptor_beta and contributes to retinoic_acid-induced apoptosis and growth inhibition .
19623543	0	retinoic_acid_receptor_beta	32,59	Myc	25,28	retinoic acid receptor beta	Myc	5915	4609	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Epigenetic regulation of Myc on retinoic_acid_receptor_beta and PDLIM4 in RWPE1 cells .
9511735	0	retinoic_acid_receptor_beta	32,59	RAR_beta	61,69	retinoic acid receptor beta	RAR beta	5915	5915	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Transcriptional upregulation of retinoic_acid_receptor_beta -LRB- RAR_beta -RRB- expression by phenylacetate in human neuroblastoma cells .
9822923	0	retinoic_acid_receptor_beta	22,49	RAR_beta	59,67	retinoic acid receptor beta	RAR beta	5915	5915	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Reduced expression of retinoic_acid_receptor_beta protein -LRB- RAR_beta -RRB- in human papillary_thyroid_carcinoma : immunohistochemical and western blot study .
9240560	0	retinoic_acid_receptor_beta	12,39	RARbeta	41,48	retinoic acid receptor beta	RARbeta	218772(Tax:10090)	218772(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the retinoic_acid_receptor_beta -LRB- RARbeta -RRB- during mouse development .
9361192	0	retinoic_acid_receptor_beta	39,66	c-jun	24,29	retinoic acid receptor beta	c-jun	5915	3725	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of c-jun , but not retinoic_acid_receptor_beta , is associated with F9_teratocarcinoma stem cell differentiation induced by polyamine depletion .
10748061	0	retinoic_acid_receptor_gamma	25,53	TFIIH	0,5	retinoic acid receptor gamma	TFIIH	5916	2966	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	TFIIH interacts with the retinoic_acid_receptor_gamma and phosphorylates its AF-1-activating domain through cdk7 .
9924183	0	retinoid-X_receptor_alpha	25,50	RXRalpha	52,60	retinoid-X receptor alpha	RXRalpha	25271(Tax:10116)	25271(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Glucocorticoids increase retinoid-X_receptor_alpha -LRB- RXRalpha -RRB- expression and enhance thyroid hormone action in primary cultured rat hepatocytes .
22960220	0	retinoid-inducible_gene_1	54,79	prostaglandin_D2	19,35	retinoid-inducible gene 1	prostaglandin D2	5920	5730	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	Involvement of the prostaglandin_D2 signal pathway in retinoid-inducible_gene_1 -LRB- RIG1 -RRB- - mediated suppression of cell invasion in testis_cancer cells .
22869035	0	retinoid-related_orphan_receptor_alpha	81,119	RORA	121,125	retinoid-related orphan receptor alpha	RORA	6095	6095	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A genome-wide association study of post-traumatic_stress_disorder identifies the retinoid-related_orphan_receptor_alpha -LRB- RORA -RRB- gene as a significant risk locus .
25125681	0	retinoid_X_receptor	16,35	AEG-1	0,5	retinoid X receptor	AEG-1	6256	92140	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	AEG-1 regulates retinoid_X_receptor and inhibits retinoid signaling .
9812988	0	retinoid_X_receptor	70,89	Bcl3	0,4	retinoid X receptor	Bcl3	6256	602	Gene	Gene	coactivator|nmod|START_ENTITY END_ENTITY|nmod|coactivator	Bcl3 , an IkappaB protein , as a novel transcription coactivator of the retinoid_X_receptor .
7852380	0	retinoid_X_receptor	40,59	RAR	35,38	retinoid X receptor	RAR	6256	5914	Gene	Gene	receptor|dep|START_ENTITY receptor|appos|END_ENTITY	Endogenous retinoic_acid receptor -LRB- RAR -RRB- - retinoid_X_receptor -LRB- RXR -RRB- heterodimers are the major functional forms regulating retinoid-responsive elements in adult human keratinocytes .
19791803	0	retinoid_X_receptor	59,78	RXR	80,83	retinoid X receptor	RXR	6256	6256	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Modeling , synthesis and biological evaluation of potential retinoid_X_receptor -LRB- RXR -RRB- selective agonists : novel analogues of 4 - -LSB- 1 - -LRB- 3,5,5,8,8-pentamethyl-5 ,6,7,8 - tetrahydro-2-naphthyl -RRB- ethynyl -RSB- benzoic_acid -LRB- bexarotene -RRB- .
24180745	0	retinoid_X_receptor	60,79	RXR	81,84	retinoid X receptor	RXR	6256	6256	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Modeling , synthesis , and biological evaluation of potential retinoid_X_receptor -LRB- RXR -RRB- selective agonists : novel analogues of 4 - -LSB- 1 - -LRB- 3,5,5,8,8-pentamethyl-5 ,6,7,8 - tetrahydro-2-naphthyl -RRB- ethynyl -RSB- benzoic_acid -LRB- bexarotene -RRB- and -LRB- E -RRB- -3 - -LRB- 3 - -LRB- 1,2,3,4-tetrahydro-1 ,1,4,4,6 - pentamethylnaphthalen-7-yl -RRB- -4 - hydroxyphenyl -RRB- acrylic_acid -LRB- CD3254 -RRB- .
26159320	0	retinoid_X_receptor	49,68	RXR	70,73	retinoid X receptor	RXR	6256	6256	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and expression analysis of the retinoid_X_receptor -LRB- RXR -RRB- gene in golden pompano Trachinotus ovatus fed Artemia nauplii with different enrichments .
18832669	0	retinoid_X_receptor	66,85	TSLP	47,51	retinoid X receptor	TSLP	6256	85480	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Cutting edge : Inhibition of NF-kappaB-mediated TSLP expression by retinoid_X_receptor .
10900149	0	retinoid_X_receptor	4,23	aldehyde_dehydrogenase_2	54,78	retinoid X receptor	aldehyde dehydrogenase 2	6256	217	Gene	Gene	element|compound|START_ENTITY element|nmod|promoter promoter|amod|END_ENTITY	The retinoid_X_receptor response element in the human aldehyde_dehydrogenase_2 promoter is antagonized by the chicken ovalbumin upstream promoter family of orphan receptors .
14754907	0	retinoid_X_receptor	52,71	lysosomal_phospholipase_A2	13,39	retinoid X receptor	lysosomal phospholipase A2	6256	23659	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of lysosomal_phospholipase_A2 through the retinoid_X_receptor in THP-1 cells .
21402532	0	retinoid_X_receptor-a	62,83	TRb1	54,58	retinoid X receptor-a	TRb1	6256	10221	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The cloning , expression and the binding ability with TRb1 of retinoid_X_receptor-a gene -RSB- .
23977068	0	retinoid_X_receptor_alpha	42,67	RXRa	69,73	retinoid X receptor alpha	RXRa	20181(Tax:10090)	20181(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Sexually dimorphic genome-wide binding of retinoid_X_receptor_alpha -LRB- RXRa -RRB- determines male-female differences in the expression of hepatic lipid processing genes in mice .
21561764	0	retinoid_X_receptor_alpha	15,40	b-catenin	54,63	retinoid X receptor alpha	b-catenin	6256	1499	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Suppression of retinoid_X_receptor_alpha and aberrant b-catenin expression significantly associates with progression of colorectal_carcinoma .
19767119	0	retinoid_X_receptor_alpha	134,159	cJun-N-terminal_kinase_1_and_2	20,50	retinoid X receptor alpha	cJun-N-terminal kinase 1 and 2	20181(Tax:10090)	26419;26420	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Redundant roles for cJun-N-terminal_kinase_1_and_2 in interleukin-1beta-mediated reduction and modification of murine hepatic nuclear retinoid_X_receptor_alpha .
12753917	0	retinoid_X_receptor_alpha	33,58	peroxisome_proliferator-activated_receptor_alpha	78,126	retinoid X receptor alpha	peroxisome proliferator-activated receptor alpha	20181(Tax:10090)	19013(Tax:10090)	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	In vivo stabilization of nuclear retinoid_X_receptor_alpha in the presence of peroxisome_proliferator-activated_receptor_alpha .
15107851	0	retinoid_X_receptor_beta	69,93	Cnot7	47,52	retinoid X receptor beta	Cnot7	20182(Tax:10090)	18983(Tax:10090)	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Oligo-astheno-teratozoospermia in mice lacking Cnot7 , a regulator of retinoid_X_receptor_beta .
19571381	0	retinoid_x_receptor	91,110	adipose_differentiation-related_protein	29,68	retinoid x receptor	adipose differentiation-related protein	6256	123	Gene	Gene	activation|nmod|START_ENTITY induces|nmod|activation induces|dobj|END_ENTITY	Docosahexaenoic_acid induces adipose_differentiation-related_protein through activation of retinoid_x_receptor in human choriocarcinoma BeWo cells .
7010968	0	retinol-binding_protein	17,40	RBP	42,45	retinol-binding protein	RBP	5950	5950	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	-LSB- Localization of retinol-binding_protein -LRB- RBP -RRB- in ocular tissues .
17339024	0	retinol-binding_protein	35,58	STRA6	0,5	retinol-binding protein	STRA6	5950	64220	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	STRA6 , a cell-surface receptor for retinol-binding_protein : the plot thickens .
3558401	1	retinol-binding_protein	145,168	cytoplasmic_retinol-binding_protein	172,207	retinol-binding protein	cytoplasmic retinol-binding protein	281444(Tax:9913)	537379(Tax:9913)	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Retinol transfer from plasma retinol-binding_protein to cytoplasmic_retinol-binding_protein with retinyl-ester formation as the intermediate step .
1483476	0	retinol-binding_protein	146,169	retinol-binding_protein	55,78	retinol-binding protein	retinol-binding protein	5950	100135913(Tax:8022)	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The primary structure of piscine -LRB- Oncorhynchus_mykiss -RRB- retinol-binding_protein and a comparison with the three-dimensional structure of mammalian retinol-binding_protein .
1483476	0	retinol-binding_protein	55,78	retinol-binding_protein	146,169	retinol-binding protein	retinol-binding protein	100135913(Tax:8022)	5950	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	The primary structure of piscine -LRB- Oncorhynchus_mykiss -RRB- retinol-binding_protein and a comparison with the three-dimensional structure of mammalian retinol-binding_protein .
8770937	0	retinol-binding_protein	40,63	retinol-binding_protein	65,88	retinol-binding protein	retinol-binding protein	25703(Tax:10116)	25703(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Regulation and localization of cellular retinol-binding_protein , retinol-binding_protein , cellular retinoic_acid-binding protein -LRB- CRABP -RRB- , and CRABP_II in the uterus of the pseudopregnant rat .
8770937	0	retinol-binding_protein	65,88	retinol-binding_protein	40,63	retinol-binding protein	retinol-binding protein	25703(Tax:10116)	25703(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Regulation and localization of cellular retinol-binding_protein , retinol-binding_protein , cellular retinoic_acid-binding protein -LRB- CRABP -RRB- , and CRABP_II in the uterus of the pseudopregnant rat .
20544399	0	retinol-binding_protein-4	15,40	RBP4	42,46	retinol-binding protein-4	RBP4	5950	5950	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of retinol-binding_protein-4 -LRB- RBP4 -RRB- with lipid parameters in obese women .
23584360	0	retinol-binding_protein_4	7,32	RBP4	34,38	retinol-binding protein 4	RBP4	5950	5950	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Plasma retinol-binding_protein_4 -LRB- RBP4 -RRB- levels and risk of coronary_heart_disease : a prospective analysis among women in the nurses ' health study .
23707795	0	retinol-binding_protein_4	62,87	RBP4	89,93	retinol-binding protein 4	RBP4	396166(Tax:9031)	396166(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ontogenic expression pattern and genetic polymorphisms of the retinol-binding_protein_4 -LRB- RBP4 -RRB- gene in Erlang mountainous chickens .
19846170	0	retinol-binding_protein_4	20,45	adiponectin	70,81	retinol-binding protein 4	adiponectin	5950	9370	Gene	Gene	Elevation|nmod|START_ENTITY Elevation|nmod|END_ENTITY	Elevation of plasma retinol-binding_protein_4 and reduction of plasma adiponectin in subjects with cerebral_infarction .
20376890	0	retinol-binding_protein_4	22,47	adiponectin	88,99	retinol-binding protein 4	adiponectin	5950	9370	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of plasma retinol-binding_protein_4 , adiponectin , and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients .
26770384	0	retinol-binding_protein_4	26,51	glucose_transporter_type_4	68,94	retinol-binding protein 4	glucose transporter type 4	25703(Tax:10116)	25139(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Sitagliptin downregulates retinol-binding_protein_4 and upregulates glucose_transporter_type_4 expression in a type_2_diabetes_mellitus rat model .
19766271	0	retinol-binding_protein_4	15,40	insulin	60,67	retinol-binding protein 4	insulin	5950	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Elevated serum retinol-binding_protein_4 is associated with insulin resistance in older women .
21711373	0	retinol-binding_protein_4	21,46	insulin	52,59	retinol-binding protein 4	insulin	5950	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Association of serum retinol-binding_protein_4 with insulin resistance and metabolic parameters during olanzapine therapy .
26619134	0	retinol_binding_protein_4	100,125	RBP4	127,131	retinol binding protein 4	RBP4	19662(Tax:10090)	19662(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Male mice are susceptible to high fat diet-induced hyperglycaemia and display increased circulatory retinol_binding_protein_4 -LRB- RBP4 -RRB- levels and its expression in visceral adipose depots .
17661007	0	retinol_binding_protein_4	14,39	adiponectin	82,93	retinol binding protein 4	adiponectin	5950	9370	Gene	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of retinol_binding_protein_4 production in primary human adipocytes by adiponectin , troglitazone and TNF-alpha .
14596915	0	retinol_dehydrogenase_10	52,76	RDH10	78,83	retinol dehydrogenase 10	RDH10	157506	157506	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and transcription of the human retinol_dehydrogenase_10 -LRB- RDH10 -RRB- gene .
17849458	0	retinol_dehydrogenase_10	25,49	Rdh10	51,56	retinol dehydrogenase 10	Rdh10	98711(Tax:10090)	98711(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the murine retinol_dehydrogenase_10 -LRB- Rdh10 -RRB- gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation .
18779497	0	retinol_dehydrogenase_12	39,63	RDH12	65,70	retinol dehydrogenase 12	RDH12	145226	145226	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a novel mutation in the retinol_dehydrogenase_12 -LRB- RDH12 -RRB- gene with autosomal_dominant_retinitis_pigmentosa .
18834580	0	retinoschisin	116,129	X-linked_retinoschisis	54,76	retinoschisin	X-linked retinoschisis	6247	6247	Gene	Gene	Relation|nmod|START_ENTITY Relation|nmod|END_ENTITY	Relation of response to treatment with dorzolamide in X-linked_retinoschisis to the mechanism of functional loss in retinoschisin .
19293990	0	reversion-induced_LIM_protein	16,45	RIL	47,50	reversion-induced LIM protein	RIL	24915(Tax:10116)	24915(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of reversion-induced_LIM_protein -LRB- RIL -RRB- in the rat central nervous system .
17329256	0	reversion-inducing_cysteine-rich_protein_with_Kazal_motifs	4,62	membrane_type_1_matrix_metalloproteinase	85,125	reversion-inducing cysteine-rich protein with Kazal motifs	membrane type 1 matrix metalloproteinase	8434	4323	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The reversion-inducing_cysteine-rich_protein_with_Kazal_motifs -LRB- RECK -RRB- interacts with membrane_type_1_matrix_metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways .
16046057	0	reversion-inducing_cysteine-rich_protein_with_kazal_motifs	15,73	EMMPRIN	133,140	reversion-inducing cysteine-rich protein with kazal motifs	EMMPRIN	8434	682	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of reversion-inducing_cysteine-rich_protein_with_kazal_motifs -LRB- RECK -RRB- and extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- , with MMP-2 , MMP-9 , and survival in colorectal_cancer .
16046057	0	reversion-inducing_cysteine-rich_protein_with_kazal_motifs	15,73	MMP-2	148,153	reversion-inducing cysteine-rich protein with kazal motifs	MMP-2	8434	4313	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of reversion-inducing_cysteine-rich_protein_with_kazal_motifs -LRB- RECK -RRB- and extracellular_matrix_metalloproteinase_inducer -LRB- EMMPRIN -RRB- , with MMP-2 , MMP-9 , and survival in colorectal_cancer .
6442022	0	rhesus-system_antigen_D	87,110	RhO	111,114	rhesus-system antigen D	RhO	6010	6010	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Ultrastructure and cytochemical indices of lymphocytes from donors immunized with the rhesus-system_antigen_D -LRB- RhO -RRB- -RSB- .
15146061	0	rho	85,88	Rho_kinase	0,10	rho	Rho kinase	212541(Tax:10090)	19878(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY regulates|nmod|activation regulates|nsubj|END_ENTITY	Rho_kinase regulates the intracellular micromechanical response of adherent cells to rho activation .
26804998	0	rho-kinase	89,99	angiotensin_II	52,66	rho-kinase	angiotensin II	19878(Tax:10090)	11606(Tax:10090)	Gene	Gene	pathways|amod|START_ENTITY END_ENTITY|nmod|pathways	Methylmercury affects cerebrovascular reactivity to angiotensin_II and acetylcholine via rho-kinase and nitric_oxide pathways in mice .
19331812	0	rhoA	67,71	Ornithine_decarboxylase	0,23	rhoA	Ornithine decarboxylase	117273(Tax:10116)	24609(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Ornithine_decarboxylase regulates the activity and localization of rhoA via polyamination .
11854031	0	rhoGAP	56,62	ARHGAP12	32,40	rhoGAP	ARHGAP12	392	94134	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Cloning and characterization of ARHGAP12 , a novel human rhoGAP gene .
7488186	0	rhodanese	6,15	Tst	22,25	rhodanese	Tst	22117(Tax:10090)	22117(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mouse rhodanese gene -LRB- Tst -RRB- : cDNA cloning , sequencing , and recombinant protein expression .
7608189	0	rhodanese	88,97	mercaptopyruvate_sulfurtransferase	10,44	rhodanese	mercaptopyruvate sulfurtransferase	25274(Tax:10116)	192172(Tax:10116)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	Cytosolic mercaptopyruvate_sulfurtransferase is evolutionarily related to mitochondrial rhodanese .
7608189	1	rhodanese	225,234	mercaptopyruvate_sulfurtransferase	178,212	rhodanese	mercaptopyruvate sulfurtransferase	25274(Tax:10116)	192172(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Striking similarity in active site amino_acid sequence and the increase in the mercaptopyruvate_sulfurtransferase activity of rhodanese by site-directed mutagenesis .
19234347	0	rhodopsin	76,85	AP-1	120,124	rhodopsin	AP-1	493763(Tax:9615)	609429(Tax:9615)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|compound|END_ENTITY	Steroids do not prevent photoreceptor_degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition .
10750831	0	rhodopsin	4,13	IRBP	36,40	rhodopsin	IRBP	212541(Tax:10090)	19661(Tax:10090)	Gene	Gene	cycle|compound|START_ENTITY preserved|nsubjpass|cycle preserved|nmod|mice mice|amod|END_ENTITY	The rhodopsin cycle is preserved in IRBP `` knockout '' mice despite abnormalities in retinal structure and function .
1623951	0	rhodopsin	37,46	IRBP	96,100	rhodopsin	IRBP	509933(Tax:9913)	281443(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Early expression and localization of rhodopsin and interphotoreceptor_retinoid-binding_protein -LRB- IRBP -RRB- in the developing fetal bovine retina .
8150029	0	rhodopsin	60,69	IRBP	45,49	rhodopsin	IRBP	6010	5949	Gene	Gene	regeneration|compound|START_ENTITY enhances|dobj|regeneration enhances|nsubj|Interphotoreceptor_retinoid_binding_protein Interphotoreceptor_retinoid_binding_protein|appos|END_ENTITY	Interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- enhances rhodopsin regeneration in the experimentally detached retina .
9352446	0	rhodopsin	8,17	IRBP	104,108	rhodopsin	IRBP	212541(Tax:10090)	19661(Tax:10090)	Gene	Gene	regeneration|compound|START_ENTITY regeneration|nmod|interphotoreceptor_retinoid_binding_protein interphotoreceptor_retinoid_binding_protein|appos|END_ENTITY	Delayed rhodopsin regeneration and altered distribution of interphotoreceptor_retinoid_binding_protein -LRB- IRBP -RRB- in the mi -LRB- vit -RRB- / mi -LRB- vit -RRB- -LRB- vitiligo -RRB- mouse .
15277472	0	rhodopsin	79,88	Kruppel-like_factor_15	0,22	rhodopsin	Kruppel-like factor 15	509933(Tax:9913)	407241(Tax:9913)	Gene	Gene	represses|dobj|START_ENTITY represses|nsubj|END_ENTITY	Kruppel-like_factor_15 , a zinc-finger transcriptional regulator , represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters .
8552602	0	rhodopsin	80,89	Nrl	52,55	rhodopsin	Nrl	6010	4901	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression .
8939891	0	rhodopsin	45,54	Nrl	30,33	rhodopsin	Nrl	509933(Tax:9913)	521544(Tax:9913)	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures .
8617359	0	rhodopsin	32,41	recoverin	14,23	rhodopsin	recoverin	6010	5957	Gene	Gene	START_ENTITY|nsubj|targets targets|compound|END_ENTITY	Calcium-bound recoverin targets rhodopsin kinase to membranes to inhibit rhodopsin phosphorylation .
16460036	0	rhodopsin	12,21	retinal_guanylate_cyclase	59,84	rhodopsin	retinal guanylate cyclase	6010	3000	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|activation activation|nmod|END_ENTITY	Illuminated rhodopsin is required for strong activation of retinal_guanylate_cyclase by guanylate cyclase-activating proteins .
26105054	0	rhodopsin	32,41	rhodopsin	66,75	rhodopsin	rhodopsin	6010	509933(Tax:9913)	Gene	Gene	pathway|nmod|START_ENTITY pathway|nmod|END_ENTITY	The activation pathway of human rhodopsin in comparison to bovine rhodopsin .
26105054	0	rhodopsin	66,75	rhodopsin	32,41	rhodopsin	rhodopsin	509933(Tax:9913)	6010	Gene	Gene	pathway|nmod|START_ENTITY pathway|nmod|END_ENTITY	The activation pathway of human rhodopsin in comparison to bovine rhodopsin .
9159393	0	rhodopsin_1	21,32	Pax-6	36,41	rhodopsin 1	Pax-6	42367(Tax:7227)	43833(Tax:7227)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Direct regulation of rhodopsin_1 by Pax-6 / eyeless in Drosophila : evidence for a conserved function in photoreceptors .
10591629	0	rhophilin	46,55	Ropporin	0,8	rhophilin	Ropporin	14787(Tax:10090)	76378(Tax:10090)	Gene	Gene	protein|nmod|START_ENTITY END_ENTITY|appos|protein	Ropporin , a sperm-specific binding protein of rhophilin , that is localized in the fibrous_sheath of sperm_flagella .
22892871	0	riboflavin_kinase	20,37	riboflavin_kinase	73,90	riboflavin kinase	riboflavin kinase	55312	55312	Gene	Gene	site|amod|START_ENTITY site|nmod|END_ENTITY	Key residues at the riboflavin_kinase catalytic site of the bifunctional riboflavin_kinase / FMN_adenylyltransferase from Corynebacterium_ammoniagenes .
22892871	0	riboflavin_kinase	73,90	riboflavin_kinase	20,37	riboflavin kinase	riboflavin kinase	55312	55312	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Key residues at the riboflavin_kinase catalytic site of the bifunctional riboflavin_kinase / FMN_adenylyltransferase from Corynebacterium_ammoniagenes .
24761851	0	riboflavin_transporter_2	31,55	hRFT2	56,61	riboflavin transporter 2	hRFT2	113278	113278	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Epigenetic regulation of human riboflavin_transporter_2 -LRB- hRFT2 -RRB- in cervical_cancers from Uighur women .
17585908	0	ribokinase	102,112	ribokinase	45,55	ribokinase	ribokinase	64080	64080	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of human ribokinase and comparison of its properties with E. _ coli ribokinase and human adenosine_kinase .
17585908	0	ribokinase	45,55	ribokinase	102,112	ribokinase	ribokinase	64080	64080	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification and characterization of human ribokinase and comparison of its properties with E. _ coli ribokinase and human adenosine_kinase .
25078100	0	ribonuclease	13,25	ribonuclease_1	61,75	ribonuclease	ribonuclease 1	6035	6035	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Bovine brain ribonuclease is the functional homolog of human ribonuclease_1 .
25078100	0	ribonuclease_1	61,75	ribonuclease	13,25	ribonuclease 1	ribonuclease	6035	6035	Gene	Gene	homolog|nmod|START_ENTITY homolog|nsubj|END_ENTITY	Bovine brain ribonuclease is the functional homolog of human ribonuclease_1 .
2675933	0	ribonucleotide_reductase	120,144	RNR2	145,149	ribonucleotide reductase	RNR2	853427(Tax:4932)	853427(Tax:4932)	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Relationships between sensitivity to hydroxyurea and 4-methyl-5-amino-1-formylisoquinoline_thiosemicarbazone -LRB- MAIO -RRB- and ribonucleotide_reductase RNR2 mRNA levels in strains of Saccharomyces_cerevisiae .
25881688	0	ribophorin_II	44,57	RPN2	59,63	ribophorin II	RPN2	6185	6185	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The expression and clinical significance of ribophorin_II -LRB- RPN2 -RRB- in human breast_cancer .
2066112	0	ribophorin_II	15,28	RPN_II	30,36	ribophorin II	RPN II	6185	6185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the ribophorin_II -LRB- RPN_II -RRB- gene to human chromosome 20q12-q13 .1 by in-situ hybridization .
21994950	0	ribosomal_S6_kinase	100,119	ORF45/RSK	121,130	ribosomal S6 kinase	ORF45/RSK	6196	4961474(Tax:37296)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4B -LRB- EIF4B -RRB- by open reading frame 45/p90 ribosomal_S6_kinase -LRB- ORF45/RSK -RRB- signaling axis facilitates protein translation during Kaposi_sarcoma-associated herpesvirus -LRB- KSHV -RRB- lytic replication .
11964089	0	ribosomal_S6_kinase	14,33	RSK	35,38	ribosomal S6 kinase	RSK	6196	6196	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of ribosomal_S6_kinase -LRB- RSK -RRB- during porcine oocyte maturation .
9792677	0	ribosomal_S6_kinase	15,34	RSK-B	0,5	ribosomal S6 kinase	RSK-B	6196	8986	Gene	Gene	member|amod|START_ENTITY END_ENTITY|appos|member	RSK-B , a novel ribosomal_S6_kinase family member , is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase -LRB- p38alphaMAPK -RRB- .
21994950	0	ribosomal_S6_kinase	100,119	eukaryotic_translation_initiation_factor_4B	19,62	ribosomal S6 kinase	eukaryotic translation initiation factor 4B	6196	1975	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of eukaryotic_translation_initiation_factor_4B -LRB- EIF4B -RRB- by open reading frame 45/p90 ribosomal_S6_kinase -LRB- ORF45/RSK -RRB- signaling axis facilitates protein translation during Kaposi_sarcoma-associated herpesvirus -LRB- KSHV -RRB- lytic replication .
21075852	0	ribosomal_S6_kinase_1	22,43	RSK1	45,49	ribosomal S6 kinase 1	RSK1	6195	6195	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Regulatory effects of ribosomal_S6_kinase_1 -LRB- RSK1 -RRB- in IFN signaling .
12842086	0	ribosomal_protein_L11	35,56	HDM2	14,18	ribosomal protein L11	HDM2	6135	4193	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activity activity|compound|END_ENTITY	Regulation of HDM2 activity by the ribosomal_protein_L11 .
15152193	0	ribosomal_protein_L11	18,39	p53	79,82	ribosomal protein L11	p53	6135	7157	Gene	Gene	role|nmod|START_ENTITY role|nmod|activation activation|compound|END_ENTITY	Essential role of ribosomal_protein_L11 in mediating growth inhibition-induced p53 activation .
9920051	0	ribosomal_protein_L14	51,72	RPL14	79,84	ribosomal protein L14	RPL14	9045	9045	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Trinucleotide repeat length variation in the human ribosomal_protein_L14 gene -LRB- RPL14 -RRB- : localization to 3p21 .3 and loss of heterozygosity in lung and oral_cancers .
11170736	0	ribosomal_protein_L16A	20,42	rpl16a	4,10	ribosomal protein L16A	rpl16a	854673(Tax:4932)	854673(Tax:4932)	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The rpl16a gene for ribosomal_protein_L16A identified from expressed sequence tags is differentially expressed during sexual development of Aspergillus_nidulans .
15314174	0	ribosomal_protein_L23	44,65	HDM2	14,18	ribosomal protein L23	HDM2	9349	4193	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of HDM2 and activation of p53 by ribosomal_protein_L23 .
15314174	0	ribosomal_protein_L23	44,65	p53	37,40	ribosomal protein L23	p53	9349	7157	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of HDM2 and activation of p53 by ribosomal_protein_L23 .
8325365	0	ribosomal_protein_L32	60,81	rpL32	83,88	ribosomal protein L32	rpL32	852185(Tax:4932)	852185(Tax:4932)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Direct binding of yeast transcription factor -LRB- TFIID -RRB- to the ribosomal_protein_L32 -LRB- rpL32 -RRB- TATA-less promoter sequence .
15308643	0	ribosomal_protein_L5	66,86	p53	28,31	ribosomal protein L5	p53	6125	7157	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|ubiquitination ubiquitination|compound|END_ENTITY	Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal_protein_L5 .
20554519	0	ribosomal_protein_L5	53,73	p53	93,96	ribosomal protein L5	p53	6125	7157	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Perturbation of 60 S ribosomal biogenesis results in ribosomal_protein_L5 - and L11-dependent p53 activation .
3883346	0	ribosomal_protein_L7	15,35	L12	36,39	ribosomal protein L7	L12	6129	6136	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of ribosomal_protein_L7 / L12 in control of translational accuracy .
19789271	0	ribosomal_protein_P0	25,45	Mrt4	82,86	ribosomal protein P0	Mrt4	851052(Tax:4932)	853860(Tax:4932)	Gene	Gene	Role|nmod|START_ENTITY END_ENTITY|nsubj|Role	Role and dynamics of the ribosomal_protein_P0 and its related trans-acting factor Mrt4 during ribosome assembly in Saccharomyces_cerevisiae .
9915854	0	ribosomal_protein_S10	58,79	Pituitary_tumor-transforming_gene	0,33	ribosomal protein S10	Pituitary tumor-transforming gene	6204	9232	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Pituitary_tumor-transforming_gene protein associates with ribosomal_protein_S10 and a novel human homologue of DnaJ in testicular cells .
19912438	0	ribosomal_protein_S13	6,27	p27	83,86	ribosomal protein S13	p27	6207	3429	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Human ribosomal_protein_S13 promotes gastric_cancer growth through down-regulating p27 -LRB- Kip1 -RRB- .
19953637	0	ribosomal_protein_S17	41,62	RPS17	69,74	ribosomal protein S17	RPS17	6218	6218	Gene	Gene	gene|amod|START_ENTITY mutation|nmod|gene mutation|appos|END_ENTITY	A novel initiation codon mutation in the ribosomal_protein_S17 gene -LRB- RPS17 -RRB- in a patient with Diamond-Blackfan_anemia .
2507396	0	ribosomal_protein_S17	48,69	RPS17	28,33	ribosomal protein S17	RPS17	39088(Tax:7227)	39088(Tax:7227)	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	The Drosophila_melanogaster RPS17 gene encoding ribosomal_protein_S17 .
11716516	0	ribosomal_protein_S19	47,68	Fibroblast_growth_factor-2	0,26	ribosomal protein S19	Fibroblast growth factor-2	6223	2247	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fibroblast_growth_factor-2 interacts with free ribosomal_protein_S19 .
12358933	0	ribosomal_protein_S19	155,176	RPS19	178,183	ribosomal protein S19	RPS19	6223	6223	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Familial_transient_erythroblastopenia of childhood is associated with the chromosome 19q13 .2 region but not caused by mutations in coding sequences of the ribosomal_protein_S19 -LRB- RPS19 -RRB- gene .
19101821	0	ribosomal_protein_S25	53,74	RPS25	81,86	ribosomal protein S25	RPS25	100465707	100465707	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	cDNA , genomic sequence cloning and overexpression of ribosomal_protein_S25 gene -LRB- RPS25 -RRB- from the Giant_Panda .
23728348	0	ribosomal_protein_S26	4,25	p53	36,39	ribosomal protein S26	p53	6231	7157	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|compound|END_ENTITY	The ribosomal_protein_S26 regulates p53 activity in response to DNA damage .
23188828	0	ribosomal_protein_S3	19,39	TRAF2	58,63	ribosomal protein S3	TRAF2	6188	7186	Gene	Gene	mediates|amod|START_ENTITY mediates|compound|END_ENTITY	Phosphorylation of ribosomal_protein_S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung_cancer cells .
18973764	0	ribosomal_protein_S3	6,26	uracil-DNA_glycosylase	50,72	ribosomal protein S3	uracil-DNA glycosylase	6188	7374	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human ribosomal_protein_S3 -LRB- hRpS3 -RRB- interacts with uracil-DNA_glycosylase -LRB- hUNG -RRB- and stimulates its glycosylase activity .
17087515	0	ribosomal_protein_S6	57,77	Death-associated_protein_kinase	0,31	ribosomal protein S6	Death-associated protein kinase	6194	1612	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Death-associated_protein_kinase phosphorylates mammalian ribosomal_protein_S6 and reduces protein synthesis .
21233202	0	ribosomal_protein_S6	14,34	casein_kinase_1	54,69	ribosomal protein S6	casein kinase 1	6194	122011	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Regulation of ribosomal_protein_S6 phosphorylation by casein_kinase_1 and protein phosphatase 1 .
24557881	0	ribosomal_protein_S6	42,62	mTORC2	16,22	ribosomal protein S6	mTORC2	20104(Tax:10090)	74343(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Pivotal role of mTORC2 and involvement of ribosomal_protein_S6 in cardioprotective signaling .
26241676	0	ribosomal_protein_S6	90,110	nucleosome_assembly_protein_1	18,47	ribosomal protein S6	nucleosome assembly protein 1	829298(Tax:3702)	818077(Tax:3702)	Gene	Gene	partner|nmod|START_ENTITY Identification|nmod|partner Identification|nmod|END_ENTITY	Identification of nucleosome_assembly_protein_1 -LRB- NAP1 -RRB- as an interacting partner of plant ribosomal_protein_S6 -LRB- RPS6 -RRB- and a positive regulator of rDNA transcription .
11705993	0	ribosomal_protein_S6	78,98	p70_S6K	115,122	ribosomal protein S6	p70 S6K	6194	6198	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	The activated glucocorticoid_receptor modulates presumptive autoregulation of ribosomal_protein_S6 protein kinase , p70_S6K .
14522890	0	ribosomal_protein_S6_and_4E-BP1	52,83	mammalian_target_of_rapamycin	130,159	ribosomal protein S6 and 4E-BP1	mammalian target of rapamycin	6194;1978	2475	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Bcr-Abl kinase modulates the translation regulators ribosomal_protein_S6_and_4E-BP1 in chronic_myelogenous_leukemia cells via the mammalian_target_of_rapamycin .
23747103	0	ribosomal_protein_S8	81,101	RPS8	103,107	ribosomal protein S8	RPS8	101117800	101117800	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Discrimination between ovine Babesia and Theileria species in China based on the ribosomal_protein_S8 -LRB- RPS8 -RRB- gene .
22709790	0	ribosome_binding_protein_1	18,44	RRBP1	46,51	ribosome binding protein 1	RRBP1	6238	6238	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of ribosome_binding_protein_1 -LRB- RRBP1 -RRB- in breast_cancer .
10899132	0	ribosome_recycling_factor	8,33	RRF	35,38	ribosome recycling factor	RRF	92399	92399	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of ribosome_recycling_factor -LRB- RRF -RRB- in translational coupling .
12960150	0	ribosome_recycling_factor	26,51	elongation_factor_G	55,74	ribosome recycling factor	elongation factor G	92399	85476	Gene	Gene	Release|nmod|START_ENTITY Release|nmod|END_ENTITY	Release of ribosome-bound ribosome_recycling_factor by elongation_factor_G .
18948280	0	ribosome_recycling_factor	64,89	elongation_factor_G	101,120	ribosome recycling factor	elongation factor G	92399	85476	Gene	Gene	RRF|appos|START_ENTITY RRF|appos|END_ENTITY	The role of GTP in transient splitting of 70S ribosomes by RRF -LRB- ribosome_recycling_factor -RRB- and EF-G -LRB- elongation_factor_G -RRB- .
11710833	0	ribozyme	44,52	Fas-L	19,24	ribozyme	Fas-L	356	14103(Tax:10090)	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Down-regulation of Fas-L in glioma cells by ribozyme reduces cell apoptosis , tumour-infiltrating cells , and liver_damage but accelerates tumour formation in nude_mice .
12971991	0	ric-8	14,19	synembryn	21,30	ric-8	synembryn	101489(Tax:10090)	101489(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of ric-8 -LRB- synembryn -RRB- gene in the nervous system of developing and adult mouse .
25714006	0	rictor	18,24	Polo-like_kinase_1	49,67	rictor	Polo-like kinase 1	253260	5347	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of rictor as a novel substrate of Polo-like_kinase_1 .
10838093	0	rlst-1	135,141	Oatp4	60,65	rlst-1	Oatp4	58978(Tax:10116)	58978(Tax:10116)	Gene	Gene	Identification|dep|START_ENTITY Identification|nmod|END_ENTITY	Identification of organic_anion_transporting_polypeptide_4 -LRB- Oatp4 -RRB- as a major full-length isoform of the liver-specific_transporter-1 -LRB- rlst-1 -RRB- in rat liver .
20949100	0	rod-derived_cone_viability_factor	14,47	CRX	62,65	rod-derived cone viability factor	CRX	234404(Tax:10090)	12951(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|role role|nmod|END_ENTITY	Expression of rod-derived_cone_viability_factor : dual role of CRX in regulating promoter activity and cell-type specificity .
19117942	0	rod_1	9,14	vimentin	31,39	rod 1	vimentin	9991	7431	Gene	Gene	interactions|amod|START_ENTITY interactions|nmod|END_ENTITY	Head and rod_1 interactions in vimentin : identification of contact sites , structure , and changes with phosphorylation using site-directed spin labeling and electron paramagnetic resonance .
8261797	0	rod_cGMP_phosphodiesterase_beta_subunit	20,59	PDE_beta	61,69	rod cGMP phosphodiesterase beta subunit	PDE beta	399653(Tax:9615)	399653(Tax:9615)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Confirmation of the rod_cGMP_phosphodiesterase_beta_subunit -LRB- PDE_beta -RRB- nonsense mutation in affected rcd-1 Irish setters in the UK and development of a diagnostic test .
9230076	0	rolling_stone	29,42	rost	44,48	rolling stone	rost	34222(Tax:7227)	34222(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The mesodermal expression of rolling_stone -LRB- rost -RRB- is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein .
7946348	0	rop	0,3	Sec1	35,39	rop	Sec1	111335(Tax:10090)	851742(Tax:4932)	Gene	Gene	START_ENTITY|appos|homolog homolog|nmod|END_ENTITY	rop , a Drosophila homolog of yeast Sec1 and vertebrate n-Sec1 / Munc-18 proteins , is a negative regulator of neurotransmitter release in vivo .
9230076	0	rost	44,48	rolling_stone	29,42	rost	rolling stone	34222(Tax:7227)	34222(Tax:7227)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	The mesodermal expression of rolling_stone -LRB- rost -RRB- is essential for myoblast fusion in Drosophila and encodes a potential transmembrane protein .
10366449	0	rotated_abdomen	52,67	POMT1	74,79	rotated abdomen	POMT1	39297(Tax:7227)	39297(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a human homolog of the Drosophila rotated_abdomen gene -LRB- POMT1 -RRB- encoding a putative protein O-mannosyl-transferase , and assignment to human chromosome 9q34 .1 .
11606707	0	roughex	46,53	cyclin_A	21,29	roughex	cyclin A	31535(Tax:7227)	39340(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Rapid evolution of a cyclin_A inhibitor gene , roughex , in Drosophila .
19112492	0	rpL10A	33,39	NIK1	52,56	rpL10A	NIK1	837993(Tax:3702)	831457(Tax:3702)	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus .
19112492	0	rpL10A	33,39	NIK1	52,56	rpL10A	NIK1	837993(Tax:3702)	831457(Tax:3702)	Gene	Gene	START_ENTITY|acl|mediated mediated|nmod|END_ENTITY	Regulated nuclear trafficking of rpL10A mediated by NIK1 represents a defense strategy of plant cells against virus .
8325365	0	rpL32	83,88	ribosomal_protein_L32	60,81	rpL32	ribosomal protein L32	852185(Tax:4932)	852185(Tax:4932)	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Direct binding of yeast transcription factor -LRB- TFIID -RRB- to the ribosomal_protein_L32 -LRB- rpL32 -RRB- TATA-less promoter sequence .
8586415	0	rpL7A	116,121	Surf3	123,128	rpL7A	Surf3	27176(Tax:10090)	27176(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Surf5 : a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A -LRB- Surf3 -RRB- gene .
7739520	0	rpL7a	78,83	Surf-3	85,91	rpL7a	Surf-3	31588(Tax:7227)	6130	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The genomic organization of the region containing the Drosophila_melanogaster rpL7a -LRB- Surf-3 -RRB- gene differs from those of the mammalian and avian Surfeit loci .
24021814	0	rpS3	49,53	Yar1	84,88	rpS3	Yar1	855543(Tax:4932)	855837(Tax:4932)	Gene	Gene	ribosomal|dobj|START_ENTITY ribosomal|nmod|END_ENTITY	Crystal structure of the yeast ribosomal protein rpS3 in complex with its chaperone Yar1 .
25217631	0	rpS6	0,4	MMP-9	64,69	rpS6	MMP-9	6194	4318	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	rpS6 regulates blood-testis barrier dynamics via its effects on MMP-9 mediated by Akt signaling .
24386828	0	rpS6	66,70	p70s6k	58,64	rpS6	p70s6k	29304(Tax:10116)	83840(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- Swimming training enhances muscle growth and potentiates p70s6k , rpS6 protein expression in rat skeletal muscle -RSB- .
11170736	0	rpl16a	4,10	ribosomal_protein_L16A	20,42	rpl16a	ribosomal protein L16A	854673(Tax:4932)	854673(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	The rpl16a gene for ribosomal_protein_L16A identified from expressed sequence tags is differentially expressed during sexual development of Aspergillus_nidulans .
25945329	0	rpsA	45,49	Ribosomal_Protein_S1_Gene	18,43	rpsA	Ribosomal Protein S1 Gene	5964809(Tax:561007)	5964809(Tax:561007)	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the Ribosomal_Protein_S1_Gene -LRB- rpsA -RRB- as a Novel Biomarker for Mycobacterium Species Identification .
25945329	0	rpsA	45,49	Ribosomal_Protein_S1_Gene	18,43	rpsA	Ribosomal Protein S1 Gene	5964809(Tax:561007)	5964809(Tax:561007)	Gene	Gene	Evaluation|appos|START_ENTITY Evaluation|nmod|END_ENTITY	Evaluation of the Ribosomal_Protein_S1_Gene -LRB- rpsA -RRB- as a Novel Biomarker for Mycobacterium Species Identification .
15525759	0	rsk	11,14	S6KII	4,9	rsk	S6KII	33139(Tax:7227)	33139(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The S6KII -LRB- rsk -RRB- gene of Drosophila_melanogaster differentially affects an operant and a classical learning task .
11230806	0	rtARNT	126,132	aryl_hydrocarbon_receptor_nuclear_translocator	78,124	rtARNT	aryl hydrocarbon receptor nuclear translocator	100136759(Tax:8022)	100136759(Tax:8022)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Functional analysis of activation and repression domains of the rainbow_trout aryl_hydrocarbon_receptor_nuclear_translocator -LRB- rtARNT -RRB- protein isoforms .
23100440	0	rugose	11,17	Neurobeachin	55,67	rugose	Neurobeachin	44531(Tax:7227)	26960	Gene	Gene	homolog|nsubj|START_ENTITY homolog|nmod|END_ENTITY	Drosophila rugose is a functional homolog of mammalian Neurobeachin and affects synaptic architecture , brain morphology , and associative learning .
9706692	0	runt	15,19	orthodenticle	30,43	runt	orthodenticle	33059(Tax:7227)	31802(Tax:7227)	Gene	Gene	restricts|nsubj|START_ENTITY restricts|dobj|expression expression|amod|END_ENTITY	Pair-rule gene runt restricts orthodenticle expression to the presumptive head of the Drosophila embryo .
25424126	0	runt-related_transcription_factor-2	144,179	histone_deacetylase_4	108,129	runt-related transcription factor-2	histone deacetylase 4	860	9759	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|amod|END_ENTITY	Decreased histone_deacetylase_4 is associated with human osteoarthritis cartilage_degeneration by releasing histone_deacetylase_4 inhibition of runt-related_transcription_factor-2 and increasing osteoarthritis-related genes : a novel mechanism of human osteoarthritis cartilage_degeneration .
23549984	0	runt-related_transcription_factor_3	27,62	MicroRNA-148a	0,13	runt-related transcription factor 3	MicroRNA-148a	864	406940	Gene	Gene	expression|amod|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	MicroRNA-148a can regulate runt-related_transcription_factor_3 gene expression via modulation of DNA methyltransferase 1 in gastric_cancer .
22253448	0	runt-related_transcription_factor_3	8,43	RUNX3	45,50	runt-related transcription factor 3	RUNX3	864	864	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of runt-related_transcription_factor_3 -LRB- RUNX3 -RRB- in transcription regulation of natural_cytotoxicity_receptor_1 -LRB- NCR1/NKp46 -RRB- , an activating natural_killer _ -LRB- NK -RRB- _ cell_receptor .
22713854	0	runt_related_transcription_factor_2	13,48	RUNX2	50,55	runt related transcription factor 2	RUNX2	367218(Tax:10116)	367218(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role for runt_related_transcription_factor_2 -LRB- RUNX2 -RRB- as a transcriptional repressor in luteinizing granulosa cells .
19342447	0	runx2	36,41	CYP11A1	106,113	runx2	CYP11A1	12393(Tax:10090)	13070(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|nmod|END_ENTITY	The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism , including CYP11A1 in osteoblasts .
24692107	0	runx2	31,36	Dlx5	0,4	runx2	Dlx5	12393(Tax:10090)	13395(Tax:10090)	Gene	Gene	enhancer|amod|START_ENTITY regulate|dobj|enhancer regulate|nsubj|END_ENTITY	Dlx5 and mef2 regulate a novel runx2 enhancer for osteoblast-specific expression .
15292260	0	runx2	37,42	Histone_deacetylase_3	0,21	runx2	Histone deacetylase 3	860	8841	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Histone_deacetylase_3 interacts with runx2 to repress the osteocalcin promoter and regulate osteoblast differentiation .
17042739	0	runx2	56,61	nell-1	33,39	runx2	nell-1	860	4745	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Craniosynostosis-associated gene nell-1 is regulated by runx2 .
1382471	0	rutabaga	42,50	mushroom_bodies	59,74	rutabaga	mushroom bodies	32406(Tax:7227)	40436(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Preferential expression of the Drosophila rutabaga gene in mushroom_bodies , neural centers for learning in insects .
21707617	0	ryanodine_receptor	48,66	Dopamine_D1_receptor	0,20	ryanodine receptor	Dopamine D1 receptor	20190(Tax:10090)	13488(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Dopamine_D1_receptor signaling system regulates ryanodine_receptor expression after intermittent exposure to methamphetamine in primary cultures of midbrain and cerebral cortical neurons .
11279144	0	ryanodine_receptor	25,43	FKBP12	0,6	ryanodine receptor	FKBP12	6261	2280	Gene	Gene	channel|compound|START_ENTITY modulates|dobj|channel modulates|nsubj|binding binding|compound|END_ENTITY	FKBP12 binding modulates ryanodine_receptor channel gating .
11751303	0	ryanodine_receptor	49,67	FKBP12	0,6	ryanodine receptor	FKBP12	6261	2280	Gene	Gene	START_ENTITY|nsubj|modulation modulation|nummod|END_ENTITY	FKBP12 modulation of the binding of the skeletal ryanodine_receptor onto the II-III loop of the dihydropyridine_receptor .
7669046	0	ryanodine_receptor	29,47	FKBP12	141,147	ryanodine receptor	FKBP12	6261	2280	Gene	Gene	purification|nmod|START_ENTITY purification|parataxis|skeletal skeletal|advcl|association association|nmod|END_ENTITY	Affinity purification of the ryanodine_receptor / calcium release channel from fast twitch skeletal muscle based on its tight association with FKBP12 .
19296124	0	ryanodine_receptor	35,53	Homer1	66,72	ryanodine receptor	Homer1	6261	9456	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	In vitro modulation of the cardiac ryanodine_receptor activity by Homer1 .
1354642	0	ryanodine_receptor	81,99	RYR1	101,105	ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms and deduced amino_acid substitutions in the coding sequence of the ryanodine_receptor -LRB- RYR1 -RRB- gene in individuals with malignant_hyperthermia .
21157159	0	ryanodine_receptor	35,53	RYR1	60,64	ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Molecular genetic analysis of the ryanodine_receptor gene -LRB- RYR1 -RRB- in Korean malignant_hyperthermia families -RSB- .
8994903	0	ryanodine_receptor	127,145	RYR1	147,151	ryanodine receptor	RYR1	396718(Tax:9823)	396718(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Technical note : use of a PCR-single strand conformation polymorphism -LRB- PCR-SSCP -RRB- for detection of a point mutation in the swine ryanodine_receptor -LRB- RYR1 -RRB- gene .
24254650	0	ryanodine_receptor	75,93	RyR	95,98	ryanodine receptor	RyR	6261	6261	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	A comparative study indicates both positive and purifying selection within ryanodine_receptor -LRB- RyR -RRB- genes , as well as correlated evolution .
18419777	0	ryanodine_receptor	57,75	RyR2	77,81	ryanodine receptor	RyR2	20191(Tax:10090)	20191(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Physiological consequences of the P2328S mutation in the ryanodine_receptor -LRB- RyR2 -RRB- gene in genetically modified murine hearts .
25463374	0	ryanodine_receptor	76,94	RyR2	96,100	ryanodine receptor	RyR2	6262	6262	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	Short-coupled polymorphic_ventricular_tachycardia at rest linked to a novel ryanodine_receptor -LRB- RyR2 -RRB- mutation : Leaky RyR2 channels under non-stress conditions .
16481613	0	ryanodine_receptor	34,52	calstabin2	12,22	ryanodine receptor	calstabin2	20190(Tax:10090)	14226(Tax:10090)	Gene	Gene	Analysis|dep|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of calstabin2 -LRB- FKBP12 .6 -RRB- - ryanodine_receptor interactions : rescue of heart_failure by calstabin2 in mice .
16481613	0	ryanodine_receptor	34,52	calstabin2	94,104	ryanodine receptor	calstabin2	20190(Tax:10090)	14226(Tax:10090)	Gene	Gene	Analysis|dep|START_ENTITY Analysis|dep|rescue rescue|nmod|heart_failure heart_failure|nmod|END_ENTITY	Analysis of calstabin2 -LRB- FKBP12 .6 -RRB- - ryanodine_receptor interactions : rescue of heart_failure by calstabin2 in mice .
24176615	0	ryanodine_receptor_1	15,35	RYR1	37,41	ryanodine receptor 1	RYR1	396718(Tax:9823)	396718(Tax:9823)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	The effects of ryanodine_receptor_1 -LRB- RYR1 -RRB- mutation on plasma cytokines and catecholamines during prolonged restraint in pigs .
22222782	0	ryanodine_receptor_2	34,54	RYR2	56,60	ryanodine receptor 2	RYR2	6262	6262	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Postmortem genetic testing of the ryanodine_receptor_2 -LRB- RYR2 -RRB- gene in a cohort of sudden unexplained death cases .
10902927	0	ryanodine_receptor_3	47,67	RYR3	74,78	ryanodine receptor 3	RYR3	6263	6263	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure of the 5 ' end of the porcine ryanodine_receptor_3 gene -LRB- RYR3 -RRB- .
19931341	0	ryanodine_receptor_type_1	48,73	RYR1	75,79	ryanodine receptor type 1	RYR1	6261	6261	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Postmortem molecular screening for mutations in ryanodine_receptor_type_1 -LRB- RYR1 -RRB- gene in psychiatric patients suspected of having died of neuroleptic_malignant_syndrome .
17707505	0	ryanodine_receptor_type_1	22,47	RyR1	49,53	ryanodine receptor type 1	RyR1	6261	6261	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Dynamic regulation of ryanodine_receptor_type_1 -LRB- RyR1 -RRB- channel activity by Homer_1 .
9515741	0	ryanodine_receptor_type_3	41,66	RYR3	68,72	ryanodine receptor type 3	RYR3	6263	6263	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	cDNA cloning and sequencing of the human ryanodine_receptor_type_3 -LRB- RYR3 -RRB- reveals a novel alternative splice site in the RYR3 gene .
21479549	0	sEH	122,125	soluble_epoxide_hydrolase	95,120	sEH	soluble epoxide hydrolase	2053	2053	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|amod|END_ENTITY	Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble_epoxide_hydrolase -LRB- sEH -RRB- inhibitors .
23045145	0	sEH	42,45	soluble_epoxide_hydrolase	15,40	sEH	soluble epoxide hydrolase	2053	2053	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Measurement of soluble_epoxide_hydrolase -LRB- sEH -RRB- activity .
25329693	0	sFLT1	35,40	VEGF	12,16	sFLT1	VEGF	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Endometrial VEGF induces placental sFLT1 and leads to pregnancy complications .
9853965	0	sFRP-2	0,6	Wnt-4	26,31	sFRP-2	Wnt-4	20319(Tax:10090)	22417(Tax:10090)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney .
24625818	0	sFRP1	16,21	MiR-27a	0,7	sFRP1	MiR-27a	6422	407018	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MiR-27a targets sFRP1 in hFOB cells to regulate proliferation , apoptosis and differentiation .
26394112	0	sFRP2	37,42	sFRP2	95,100	sFRP2	sFRP2	6423	6423	Gene	Gene	Functions|appos|START_ENTITY Functions|dep|Role Role|nmod|END_ENTITY	Secreted_Frizzled-Related_Protein_2 -LRB- sFRP2 -RRB- Functions as a Melanogenic Stimulator ; The Role of sFRP2 in UV-Induced Hyperpigmentary_Disorders .
26394112	0	sFRP2	95,100	sFRP2	37,42	sFRP2	sFRP2	6423	6423	Gene	Gene	Role|nmod|START_ENTITY Functions|dep|Role Functions|appos|END_ENTITY	Secreted_Frizzled-Related_Protein_2 -LRB- sFRP2 -RRB- Functions as a Melanogenic Stimulator ; The Role of sFRP2 in UV-Induced Hyperpigmentary_Disorders .
26763443	0	sFRP2	37,42	sFRP2	95,100	sFRP2	sFRP2	6423	6423	Gene	Gene	Functions|appos|START_ENTITY Functions|dep|Role Role|nmod|END_ENTITY	Secreted_Frizzled-Related_Protein_2 -LRB- sFRP2 -RRB- Functions as a Melanogenic Stimulator ; the Role of sFRP2 in UV-Induced Hyperpigmentary_Disorders .
26763443	0	sFRP2	95,100	sFRP2	37,42	sFRP2	sFRP2	6423	6423	Gene	Gene	Role|nmod|START_ENTITY Functions|dep|Role Functions|appos|END_ENTITY	Secreted_Frizzled-Related_Protein_2 -LRB- sFRP2 -RRB- Functions as a Melanogenic Stimulator ; the Role of sFRP2 in UV-Induced Hyperpigmentary_Disorders .
26126628	0	sFRP5	62,67	JNK	111,114	sFRP5	JNK	309377(Tax:10116)	116554(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
26126628	0	sFRP5	62,67	secreted_frizzled-related_protein_5	25,60	sFRP5	secreted frizzled-related protein 5	309377(Tax:10116)	309377(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
14528319	0	sFlt-1	48,54	VEGF	31,35	sFlt-1	VEGF	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Adenoviral delivery of soluble VEGF receptor 1 -LRB- sFlt-1 -RRB- abrogates disease activity in murine collagen-induced_arthritis .
15352169	0	sFlt-1	46,52	vascular_endothelial_growth_factor	81,115	sFlt-1	vascular endothelial growth factor	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|appos|inhibitor inhibitor|nmod|END_ENTITY	Post-transcriptional control of expression of sFlt-1 , an endogenous inhibitor of vascular_endothelial_growth_factor .
16234975	0	sFlt1	23,28	VEGF	0,4	sFlt1	VEGF	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	inhibits|nsubj|START_ENTITY improves|advcl|inhibits improves|nsubj|END_ENTITY	VEGF improves , whereas sFlt1 inhibits , BMP2-induced bone formation and bone healing through modulation of angiogenesis .
21548585	0	sFlt1	37,42	VEGF	20,24	sFlt1	VEGF	14254(Tax:10090)	22339(Tax:10090)	Gene	Gene	1|appos|START_ENTITY receptor|dobj|1 receptor|nsubj|Delivery Delivery|nmod|END_ENTITY	Delivery of soluble VEGF receptor 1 -LRB- sFlt1 -RRB- by gene electrotransfer as a new antiangiogenic cancer therapy .
24481121	0	sLZIP	12,17	c-Jun	51,56	sLZIP	c-Jun	10488	3725	Gene	Gene	START_ENTITY|nmod|Regulation Regulation|nmod|END_ENTITY	The Role of sLZIP in Transcriptional Regulation of c-Jun and Involvement in Migration and Invasion of Cervical_Cancer Cells .
22349239	0	sMEK1	56,61	BLU	17,20	sMEK1	BLU	55671	51364	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Tumor suppressor BLU enhances pro-apoptotic activity of sMEK1 through physical interaction .
12967936	0	sPLA2	87,92	COX-1	94,99	sPLA2	COX-1	29692(Tax:10116)	26195(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2 , COX-1 and COX-2 selective inhibitors , and an LTC4 receptor antagonist .
12676927	0	sPLA2	186,191	cPLA2_alpha	202,213	sPLA2	cPLA2 alpha	18780(Tax:10090)	18783(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|activity activity|amod|END_ENTITY	Cross-talk between cytosolic phospholipase_A2 alpha -LRB- cPLA2_alpha -RRB- and secretory phospholipase_A2 -LRB- sPLA2 -RRB- in hydrogen_peroxide-induced arachidonic_acid release in murine mesangial cells : sPLA2 regulates cPLA2_alpha activity that is responsible for arachidonic_acid release .
12676927	0	sPLA2	98,103	cPLA2_alpha	53,64	sPLA2	cPLA2 alpha	18780(Tax:10090)	18783(Tax:10090)	Gene	Gene	alpha|appos|START_ENTITY alpha|appos|END_ENTITY	Cross-talk between cytosolic phospholipase_A2 alpha -LRB- cPLA2_alpha -RRB- and secretory phospholipase_A2 -LRB- sPLA2 -RRB- in hydrogen_peroxide-induced arachidonic_acid release in murine mesangial cells : sPLA2 regulates cPLA2_alpha activity that is responsible for arachidonic_acid release .
8301116	0	sag	20,23	Mtv-7	14,19	sag	Mtv-7	20215(Tax:10090)	111375(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of Mtv-7 sag gene in vivo using a retroviral vector results in selective inactivation of superantigen reactive T cells .
25848046	0	salivary_agglutinin	40,59	DMBT1	66,71	salivary agglutinin	DMBT1	1755	1755	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evolution of the rapidly mutating human salivary_agglutinin gene -LRB- DMBT1 -RRB- and population subsistence strategy .
16501170	0	sall4	0,5	tbx5	25,29	sall4	tbx5	572527(Tax:7955)	30071(Tax:7955)	Gene	Gene	acts|nsubj|START_ENTITY acts|dobj|downstream downstream|nmod|END_ENTITY	sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth .
22121809	0	salviandic_acid_B	12,29	SA-B	31,35	salviandic acid B	SA-B	117186(Tax:10116)	117186(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of salviandic_acid_B -LRB- SA-B -RRB- on activity of basement membrane-type collagenase and impact of regulatory factors in rats with cardiac_hypertrophy -RSB- .
14969849	0	salvianolic_acid_B	10,28	Smad3	32,37	salvianolic acid B	Smad3	9467	4088	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of salvianolic_acid_B on Smad3 expression in hepatic stellate cells .
16483709	0	sarcolectin	11,22	SCL	24,27	sarcolectin	SCL	3855	3855	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of sarcolectin -LRB- SCL -RRB- on human peripheral blood mononuclear cells .
15546552	0	sarcoma_protein	101,116	Src	96,99	sarcoma protein	Src	20779(Tax:10090)	20779(Tax:10090)	Gene	Gene	activation|appos|START_ENTITY activation|compound|END_ENTITY	Extracellular pressure stimulates colon_cancer cell adhesion in vitro and to surgical wounds by Src -LRB- sarcoma_protein -RRB- activation .
20704701	0	scFv	72,76	DNA-PKcs	99,107	scFv	DNA-PKcs	652070	5591	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo .
9184171	0	scFv	48,52	ETA	59,62	scFv	ETA	652070	1909	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Construction and functional characterization of scFv -LRB- 14E1 -RRB- - ETA - a novel , highly potent antibody-toxin specific for the EGF_receptor .
26071785	0	scFv	59,63	Single_Chain_Variable_Fragment_Antibody	18,57	scFv	Single Chain Variable Fragment Antibody	652070	652070	Gene	Gene	Construction|appos|START_ENTITY Construction|nmod|END_ENTITY	Construction of a Single_Chain_Variable_Fragment_Antibody -LRB- scFv -RRB- against Carbaryl and Its Interaction with Carbaryl .
9219032	0	scFv	33,37	c-myc	104,109	scFv	c-myc	652070	4609	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nsubj|expression	Primary structure and functional scFv antibody expression of an antibody against the human protooncogen c-myc .
24555933	0	scFv	26,30	p24	39,42	scFv	p24	652070	13088(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of recombinant scFv against p24 of human_immunodeficiency_virus_type_1 by phage display technology .
16755932	0	scFv	83,87	transferrin_receptor	62,82	scFv	transferrin receptor	652070	7037	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Expression , purification and activity analysis of anti-human transferrin_receptor scFv -RSB- .
9405365	0	scaffold_attachment_factor_A	32,60	SAF-A	62,67	scaffold attachment factor A	SAF-A	3192	3192	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The novel SAR-binding domain of scaffold_attachment_factor_A -LRB- SAF-A -RRB- is a target in apoptotic nuclear breakdown .
18295233	0	scapinin	39,47	Phactr3	49,56	scapinin	Phactr3	74189(Tax:10090)	74189(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Paramutation-like effects at the mouse scapinin -LRB- Phactr3 -RRB- locus .
11438654	0	scatter_factor	68,82	c-Met	84,89	scatter factor	c-Met	403441(Tax:9615)	403438(Tax:9615)	Gene	Gene	factor|appos|START_ENTITY factor|dep|END_ENTITY	The multisubstrate adapter Gab1 regulates hepatocyte growth factor -LRB- scatter_factor -RRB- - c-Met signaling for cell survival and DNA repair .
7515877	0	scatter_factor	95,109	c-Met	79,84	scatter factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	receptor|dep|START_ENTITY receptor|amod|END_ENTITY	Regulatory role of major tyrosine autophosphorylation site of kinase domain of c-Met receptor -LRB- scatter_factor / hepatocyte growth factor receptor -RRB- .
7689722	0	scatter_factor	48,62	c-Met	139,144	scatter factor	c-Met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	triggered|nmod|START_ENTITY dissociation|acl|triggered dissociation|parataxis|mediated mediated|nmod|domain domain|nmod|receptor receptor|amod|END_ENTITY	The cell dissociation and motility triggered by scatter_factor / hepatocyte_growth_factor are mediated through the cytoplasmic domain of the c-Met receptor .
7678980	0	scatter_factor	94,108	c-met	34,39	scatter factor	c-met	15234(Tax:10090)	17295(Tax:10090)	Gene	Gene	START_ENTITY|dep|Expression Expression|nmod|END_ENTITY	Expression of the proto-oncogenes c-met and c-kit and their ligands , hepatocyte_growth_factor / scatter_factor and stem_cell_factor , in SCLC cell lines and xenografts .
9548586	0	scavenger_receptor	54,72	SR-A	74,78	scavenger receptor	SR-A	4481	4481	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A naturally occurring isoform of the human macrophage scavenger_receptor -LRB- SR-A -RRB- gene generated by alternative splicing blocks modified LDL uptake .
25852127	0	scavenger_receptor-B1	52,73	ABCA1	27,32	scavenger receptor-B1	ABCA1	949	19	Gene	Gene	cells|nmod|START_ENTITY END_ENTITY|nmod|cells	Lipoprotein -LRB- a -RRB- upregulates ABCA1 in liver cells via scavenger_receptor-B1 through its oxidised phospholipids .
26056009	0	scavenger_receptor_A	17,37	miR-29a	0,7	scavenger receptor A	miR-29a	4481	407021	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	miR-29a promotes scavenger_receptor_A expression by targeting QKI -LRB- quaking -RRB- during monocyte-macrophage differentiation .
19576750	0	scavenger_receptor_B1	140,161	TNF-alpha	176,185	scavenger receptor B1	TNF-alpha	949	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK , JAK/STAT , AP-1 and IRF-1 , and depends on up-regulation of scavenger_receptor_B1 expression in TNF-alpha - and IFN-gamma-stimulated C6 glioma cells .
11279034	0	scavenger_receptor_BI	114,135	A-II	15,19	scavenger receptor BI	A-II	20778(Tax:10090)	11847(Tax:10090)	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Apolipoprotein A-II modulates the binding and selective lipid uptake of reconstituted high density lipoprotein by scavenger_receptor_BI .
12801960	0	scavenger_receptor_class_B_type_I	29,62	SR-BI	64,69	scavenger receptor class B type I	SR-BI	20778(Tax:10090)	20778(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and regulation of scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- in gall bladder epithelium .
12809509	0	scavenger_receptor_class_B_type_I	36,69	SR-BI	71,76	scavenger receptor class B type I	SR-BI	949	20778(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of human and mouse hepatic scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- in the selective uptake of low-density lipoprotein-cholesteryl_esters .
14592533	0	scavenger_receptor_class_B_type_I	12,45	SR-BI	47,52	scavenger receptor class B type I	SR-BI	949	949	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- in lipid trafficking .
24738490	0	scavenger_receptor_class_B_type_I	46,79	SR-BI	81,86	scavenger receptor class B type I	SR-BI	949	949	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	The age effect on the association between the scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- polymorphism and HDL-C level : Tehran_Lipid_and_Glucose_Study .
8969220	0	scavenger_receptor_class_B_type_I	71,104	SR-BI	106,111	scavenger receptor class B type I	SR-BI	20778(Tax:10090)	20778(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger_receptor_class_B_type_I -LRB- SR-BI -RRB- , a high density lipoprotein receptor , in steroidogenic cells of the murine adrenal gland .
11795294	0	scavenger_receptor_for_phosphatidylserine_and_oxidized_lipoprotein	14,80	SR-PSOX	82,89	scavenger receptor for phosphatidylserine and oxidized lipoprotein	SR-PSOX	58191	58191	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of scavenger_receptor_for_phosphatidylserine_and_oxidized_lipoprotein -LRB- SR-PSOX -RRB- in human atheroma .
8621257	0	schwannoma-derived_growth_factor	24,56	SDGF	58,62	schwannoma-derived growth factor	SDGF	29183(Tax:10116)	29183(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Increased expression of schwannoma-derived_growth_factor -LRB- SDGF -RRB- mRNA in rat tumor cells : involvement of SDGF in the growth promotion of rat gliomas .
12118253	0	schwannomin	15,26	Paxillin	0,8	schwannomin	Paxillin	4771	5829	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology .
9537418	0	schwannomin	38,49	betaII-spectrin	65,80	schwannomin	betaII-spectrin	4771	6711	Gene	Gene	interacts|compound|START_ENTITY interacts|nmod|END_ENTITY	Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin .
26071314	0	sclerostin	26,36	SOST	38,42	sclerostin	SOST	50964	50964	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	DNA methylation regulates sclerostin -LRB- SOST -RRB- expression in osteoarthritic chondrocytes by bone_morphogenetic_protein_2 -LRB- BMP-2 -RRB- induced changes in Smads binding affinity to the CpG region of SOST promoter .
22155511	0	sclerostin	16,26	TGF-b	0,5	sclerostin	TGF-b	80722(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	TGF-b regulates sclerostin expression via the ECR5 enhancer .
22735261	0	sclerostin	34,44	TNF-a	0,5	sclerostin	TNF-a	74499(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY stimulation|nmod|expression mediates|dobj|stimulation mediates|nsubj|END_ENTITY	TNF-a mediates the stimulation of sclerostin expression in an estrogen-deficient_condition .
24446199	0	sclerostin	18,28	TNF-a	0,5	sclerostin	TNF-a	74499(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	TNF-a upregulates sclerostin expression in obese mice fed a high-fat diet .
19292615	0	sclerostin	161,171	TNF-related_weak_inducer_of_apoptosis	27,64	sclerostin	TNF-related weak inducer of apoptosis	50964	8742	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Pro-inflammatory cytokines TNF-related_weak_inducer_of_apoptosis -LRB- TWEAK -RRB- and TNFalpha induce the mitogen-activated protein kinase -LRB- MAPK -RRB- - dependent expression of sclerostin in human osteoblasts .
26071314	0	sclerostin	26,36	bone_morphogenetic_protein_2	89,117	sclerostin	bone morphogenetic protein 2	50964	650	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	DNA methylation regulates sclerostin -LRB- SOST -RRB- expression in osteoarthritic chondrocytes by bone_morphogenetic_protein_2 -LRB- BMP-2 -RRB- induced changes in Smads binding affinity to the CpG region of SOST promoter .
20951118	0	sclerostin	65,75	erbB-3	46,52	sclerostin	erbB-3	74499(Tax:10090)	13867(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Sclerostin-erbB-3 interactions : modulation of erbB-3 activity by sclerostin .
21221677	0	sclerostin_domain-containing_protein_1	20,58	SOSTDC1	60,67	sclerostin domain-containing protein 1	SOSTDC1	25928	25928	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Contribution of the sclerostin_domain-containing_protein_1 -LRB- SOSTDC1 -RRB- gene to normal variation of peak bone mineral density in Chinese women and men .
11937021	0	scribble	15,23	GUK-holder	69,79	scribble	GUK-holder	44448(Tax:7227)	53563(Tax:7227)	Gene	Gene	Recruitment|nmod|START_ENTITY requires|nsubj|Recruitment requires|dobj|END_ENTITY	Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder , a novel DLG binding protein .
10467350	0	sdi1	26,30	p21	22,25	sdi1	p21	1026	1026	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells : implication for senescence-directed molecular therapy for cancer .
11053466	0	sec24	7,12	CEF	0,3	sec24	CEF	854697(Tax:4932)	823559(Tax:3702)	Gene	Gene	homologue|amod|START_ENTITY END_ENTITY|appos|homologue	CEF , a sec24 homologue of Arabidopsis_thaliana , enhances the survival of yeast under oxidative stress conditions .
10364170	0	sec7	38,42	p200	53,57	sec7	p200	9267	10565	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Brefeldin_A inhibited activity of the sec7 domain of p200 , a mammalian guanine_nucleotide-exchange_protein for ADP-ribosylation_factors .
18356147	0	secreted_frizzled-related_protein-5	31,66	SFRP5	68,73	secreted frizzled-related protein-5	SFRP5	6425	6425	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic inactivation of the secreted_frizzled-related_protein-5 -LRB- SFRP5 -RRB- gene in human breast_cancer is associated with unfavorable prognosis .
16567562	0	secreted_frizzled-related_protein_1	8,43	SFRP1	45,50	secreted frizzled-related protein 1	SFRP1	20377(Tax:10090)	20377(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of secreted_frizzled-related_protein_1 -LRB- SFRP1 -RRB- in wound healing .
17848950	0	secreted_frizzled-related_protein_2	36,71	SFRP2	73,78	secreted frizzled-related protein 2	SFRP2	6423	6423	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Frequent epigenetic inactivation of secreted_frizzled-related_protein_2 -LRB- SFRP2 -RRB- by promoter methylation in human gastric_cancer .
19480240	0	secreted_frizzled-related_protein_4	14,49	SFRP4	51,56	secreted frizzled-related protein 4	SFRP4	6424	6424	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of secreted_frizzled-related_protein_4 -LRB- SFRP4 -RRB- in primary_serous_ovarian_tumours .
25408147	0	secreted_frizzled-related_protein_4	15,50	SFRP4	52,57	secreted frizzled-related protein 4	SFRP4	6424	6424	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of secreted_frizzled-related_protein_4 -LRB- SFRP4 -RRB- with type 2 diabetes in patients with stable coronary_artery_disease .
26126628	0	secreted_frizzled-related_protein_5	25,60	Angiotensin_II	0,14	secreted frizzled-related protein 5	Angiotensin II	309377(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
26126628	0	secreted_frizzled-related_protein_5	25,60	JNK	111,114	secreted frizzled-related protein 5	JNK	309377(Tax:10116)	116554(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
26126628	0	secreted_frizzled-related_protein_5	25,60	sFRP5	62,67	secreted frizzled-related protein 5	sFRP5	309377(Tax:10116)	309377(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II increases secreted_frizzled-related_protein_5 -LRB- sFRP5 -RRB- expression through AT1 receptor/Rho/ROCK1 / JNK signaling in cardiomyocytes .
16410723	0	secreted_frizzled_related_protein_1	26,61	SFRP1	63,68	secreted frizzled related protein 1	SFRP1	6422	6422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Epigenetic suppression of secreted_frizzled_related_protein_1 -LRB- SFRP1 -RRB- expression in human breast_cancer .
14561758	0	secreted_frizzled_related_protein_2	4,39	SFRP2	41,46	secreted frizzled related protein 2	SFRP2	6423	6423	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The secreted_frizzled_related_protein_2 -LRB- SFRP2 -RRB- gene is a target of the Pax2 transcription factor .
25750188	0	secreted_modular_calcium-binding_protein_1	8,50	SMOC1	52,57	secreted modular calcium-binding protein 1	SMOC1	64075(Tax:10090)	64075(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of secreted_modular_calcium-binding_protein_1 -LRB- SMOC1 -RRB- in transforming growth factor b signalling and angiogenesis .
15062857	0	secreted_phosphoprotein_24	30,56	SPP2	63,67	secreted phosphoprotein 24	SPP2	281500(Tax:9913)	6694	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the human secreted_phosphoprotein_24 gene -LRB- SPP2 -RRB- and comparison of the protein sequence in nine species .
20087345	0	secreted_protein_acidic_and_rich_in_cysteine	51,95	MMP-9	12,17	secreted protein acidic and rich in cysteine	MMP-9	6678	4318	Gene	Gene	effect|nmod|START_ENTITY role|nmod|effect role|nmod|END_ENTITY	The role of MMP-9 in the anti-angiogenic effect of secreted_protein_acidic_and_rich_in_cysteine .
10757117	0	secreted_protein_acidic_and_rich_in_cysteine	16,60	SPARC	62,67	secreted protein acidic and rich in cysteine	SPARC	24791(Tax:10116)	24791(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Localization of secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- expression in the rat eye .
16735494	0	secreted_protein_acidic_and_rich_in_cysteine	68,112	SPARC	114,119	secreted protein acidic and rich in cysteine	SPARC	6678	6678	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential zonal expression and adrenocorticotropin regulation of secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- , a matricellular protein , in the midgestation human fetal adrenal gland : implications for adrenal development .
17041094	0	secreted_protein_acidic_and_rich_in_cysteine	57,101	SPARC	103,108	secreted protein acidic and rich in cysteine	SPARC	6678	6678	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Expression of a suicidal gene under control of the human secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- promoter in tumor or stromal cells led to the inhibition of tumor cell growth .
22145659	0	secreted_protein_acidic_and_rich_in_cysteine	13,57	SPARC	59,64	secreted protein acidic and rich in cysteine	SPARC	6678	6678	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Knockdown of secreted_protein_acidic_and_rich_in_cysteine -LRB- SPARC -RRB- expression diminishes radiosensitivity of glioma cells .
12482979	0	secretin	58,66	BETA2/NeuroD	38,50	secretin	BETA2/NeuroD	6343	4760	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB -1 .
6105428	0	secretin	20,28	Insulin	0,7	secretin	Insulin	6343	3630	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Insulin response to secretin , a possible basis for diagnostic test of primary_hyperparathyroidism .
3042579	0	secretin	35,43	Pancreatic_polypeptide	0,22	secretin	Pancreatic polypeptide	6343	5539	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Pancreatic_polypeptide response to secretin in obesity : effects of glucose_intolerance .
3671783	0	secretin	26,34	Peptide_YY	0,10	secretin	Peptide YY	483407(Tax:9615)	607156(Tax:9615)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Peptide_YY interacts with secretin and duodenal acidification to inhibit gastric_acid secretion .
1672662	0	secretin	22,30	Prolactin	0,9	secretin	Prolactin	6343	5617	Gene	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to secretin during the spontaneous menstrual cycle in women .
16888198	0	secretin	28,36	cyclin-dependent_kinase_1	86,111	secretin	cyclin-dependent kinase 1	6343	983	Gene	Gene	expression|amod|START_ENTITY mediated|nsubjpass|expression mediated|advcl|END_ENTITY	Retinoic_acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent_kinase_1 .
7924740	0	secretin	10,18	epidermal_growth_factor	52,75	secretin	epidermal growth factor	24769(Tax:10116)	25313(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|nmod|END_ENTITY	Effect of secretin and somatostatin on secretion of epidermal_growth_factor from Brunner 's glands in the rat .
6138366	0	secretin	33,41	gastrin	14,21	secretin	gastrin	24769(Tax:10116)	25320(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|compound|END_ENTITY	Inhibition of gastrin release by secretin is mediated by somatostatin in cultured rat antral mucosa .
1052690	0	secretin	37,45	insulin	49,56	secretin	insulin	6343	3630	Gene	Gene	effect|nmod|START_ENTITY -LSB-|dobj|effect -LSB-|nmod|secretion secretion|compound|END_ENTITY	-LSB- The effect of natural and synthetic secretin on insulin secretion -LRB- author 's transl -RRB- -RSB- .
744171	0	secretin	10,18	insulin	29,36	secretin	insulin	6343	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of secretin on plasma insulin and glucagon in man .
8364	0	secretin	86,94	insulin	7,14	secretin	insulin	6343	3630	Gene	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Plasma insulin concentration during physiological variations in immunoreactive plasma secretin .
2373268	0	secretin	17,25	pancreatic_polypeptide	27,49	secretin	pancreatic polypeptide	6343	5539	Gene	Gene	Cholecystokinin|appos|START_ENTITY END_ENTITY|nsubj|Cholecystokinin	Cholecystokinin , secretin , pancreatic_polypeptide in relation to gallbladder dynamics and gastrointestinal interdigestive motility .
6997022	0	secretin	22,30	pancreatic_polypeptide	34,56	secretin	pancreatic polypeptide	6343	5539	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Stimulatory effect of secretin on pancreatic_polypeptide in diabetic patients .
3993434	0	secretin	11,19	parathyroid_hormone	23,42	secretin	parathyroid hormone	6343	5741	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of secretin on parathyroid_hormone and calcium in normal subjects , patients with hyperparathyroidism and patients with gastrinoma .
1307917	0	secretin	74,82	peptide_YY	21,31	secretin	peptide YY	483407(Tax:9615)	607156(Tax:9615)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|action action|nmod|END_ENTITY	Inhibitory action of peptide_YY on pancreatic secretion is independent of secretin .
675202	0	secretin	53,61	somatostatin	11,23	secretin	somatostatin	483407(Tax:9615)	403993(Tax:9615)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	-LSB- Effect of somatostatin on the endogenous release of secretin and pancreatic polypeptide in the dog -RSB- .
8361528	0	secretin	49,57	vasoactive_intestinal_polypeptide	8,41	secretin	vasoactive intestinal polypeptide	483407(Tax:9615)	484038(Tax:9615)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- , secretin and gastrin in the genesis of the late exocrine pancreatic_hypersecretion , _ food_intake dependent in conscious dogs .
8930157	0	secretin_receptor	113,130	vasoactive_intestinal_polypeptide	68,101	secretin receptor	vasoactive intestinal polypeptide	81779(Tax:10116)	117064(Tax:10116)	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis and species specificity of high affinity binding of vasoactive_intestinal_polypeptide by the rat secretin_receptor .
21170691	0	secretoglobin_3A2	32,49	SCGB3A2	51,58	secretoglobin 3A2	SCGB3A2	117156	117156	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The -112 G > A polymorphism of the secretoglobin_3A2 -LRB- SCGB3A2 -RRB- gene encoding uteroglobin-related_protein_1 -LRB- UGRP1 -RRB- increases risk for the development of Graves ' _ disease in subsets of patients with elevated levels of immunoglobulin_E .
3608978	0	secretogranin_I	31,46	chromogranin_A	81,95	secretogranin I	chromogranin B	1114	1114	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	The primary structure of human secretogranin_I -LRB- chromogranin_B -RRB- : comparison with chromogranin_A reveals homologous terminal domains and a large intervening variable region .
2335203	0	secretogranin_I	46,61	chromogranin_B	30,44	secretogranin I	chromogranin B	12653(Tax:10090)	12653(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The organisation of the mouse chromogranin_B -LRB- secretogranin_I -RRB- gene .
19215537	0	secretogranin_I	49,64	chromogranin_a	14,28	secretogranin I	chromogranin a	281071(Tax:9913)	281070(Tax:9913)	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of chromogranin_a and chromogranin_B -LRB- secretogranin_I -RRB- synthesis in bovine cultured chromaffin cells .
7575410	0	secretogranin_II	59,75	PC2	38,41	secretogranin II	PC2	24765(Tax:10116)	25121(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Characterization of the endopeptidase PC2 activity towards secretogranin_II in stably transfected PC12 cells .
17200173	0	secretogranin_III	50,67	SCG3	69,73	secretogranin III	SCG3	29106	29106	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional single-nucleotide polymorphisms in the secretogranin_III -LRB- SCG3 -RRB- gene that form secretory granules with appetite-related neuropeptides are associated with obesity .
19357184	0	secretogranin_III	26,43	Secretogranin_II	0,16	secretogranin III	Secretogranin II	20255(Tax:10090)	20254(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|compound|END_ENTITY	Secretogranin_II binds to secretogranin_III and forms secretory granules with orexin , neuropeptide_Y , and POMC .
7883050	0	secretoneurin	93,106	PC1	72,75	secretoneurin	PC1	7857	5122	Gene	Gene	generation|nmod|START_ENTITY END_ENTITY|nmod|generation	Processing of secretogranin_II by prohormone convertases : importance of PC1 in generation of secretoneurin .
9657850	0	secretory_carrier_membrane_protein_1	50,86	SCAMP1	93,99	secretory carrier membrane protein 1	SCAMP1	9522	9522	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural and functional analysis of the porcine secretory_carrier_membrane_protein_1 gene -LRB- SCAMP1 -RRB- .
10704052	0	secretory_leucocyte_protease_inhibitor	14,52	SLPI	54,58	secretory leucocyte protease inhibitor	SLPI	6590	6590	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of secretory_leucocyte_protease_inhibitor -LRB- SLPI -RRB- in human pancreatic beta-cells .
14500739	0	secretory_leukocyte_protease_inhibitor	17,55	SLPI	124,128	secretory leukocyte protease inhibitor	SLPI	84386(Tax:10116)	84386(Tax:10116)	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	Up-regulation of secretory_leukocyte_protease_inhibitor -LRB- SLPI -RRB- in the brain after ischemic_stroke : adenoviral expression of SLPI protects brain from ischemic_injury .
19505578	0	secretory_leukocyte_protease_inhibitor	53,91	SLPI	93,97	secretory leukocyte protease inhibitor	SLPI	6590	6590	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and characterization of recombinant human secretory_leukocyte_protease_inhibitor -LRB- SLPI -RRB- protein from Pichia_pastoris .
8808424	0	secretory_leukocyte_protease_inhibitor	31,69	SLPI	71,75	secretory leukocyte protease inhibitor	SLPI	6590	6590	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of immunoreactive secretory_leukocyte_protease_inhibitor -LRB- SLPI -RRB- in intestinal mucosa .
8100709	0	secretory_leukocyte_protease_inhibitor	15,53	proteinase-3	59,71	secretory leukocyte protease inhibitor	proteinase-3	6590	5657	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of secretory_leukocyte_protease_inhibitor with proteinase-3 .
24285265	0	secretory_leukoprotease_inhibitor	27,60	SLPI	62,66	secretory leukoprotease inhibitor	SLPI	20568(Tax:10090)	20568(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation and activity of secretory_leukoprotease_inhibitor -LRB- SLPI -RRB- is altered in smokers .
3947055	0	secretory_protein-I	70,89	chromogranin_A	39,53	secretory protein-I	chromogranin A	1113	1113	Gene	Gene	START_ENTITY|nsubj|characterization characterization|nmod|END_ENTITY	Structural characterization of adrenal chromogranin_A and parathyroid secretory_protein-I as homologs .
12355087	0	securin	6,13	p53	29,32	securin	p53	9232	7157	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis .
12403781	0	securin	33,40	p53	67,70	securin	p53	9232	7157	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression mediated|nsubjpass|inhibition mediated|nmod|END_ENTITY	DNA damage-induced inhibition of securin expression is mediated by p53 .
21334315	0	seizure-related_gene_6	24,46	Sez-6	48,53	seizure-related gene 6	Sez-6	20370(Tax:10090)	20370(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The distribution of the seizure-related_gene_6 -LRB- Sez-6 -RRB- protein during postnatal development of the mouse forebrain suggests multiple functions for this protein : an analysis using a new antibody .
8722778	0	sel-1	27,32	lin-12	63,69	sel-1	lin-12	179720(Tax:6239)	176282(Tax:6239)	Gene	Gene	gene|amod|START_ENTITY gene|appos|regulator regulator|acl|END_ENTITY	The Caenorhabditis_elegans sel-1 gene , a negative regulator of lin-12 and glp-1 , encodes a predicted extracellular protein .
11568451	0	selD	43,47	selenophosphate_synthetase	15,41	selD	selenophosphate synthetase	36587(Tax:7227)	36587(Tax:7227)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	The Drosophila selenophosphate_synthetase -LRB- selD -RRB- gene is required for development and cell proliferation .
16407971	0	seladin-1	12,21	DHCR24	22,28	seladin-1	DHCR24	74754(Tax:10090)	74754(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of seladin-1 / DHCR24 in cholesterol biosynthesis , APP processing and Abeta generation in vivo .
18762779	0	seladin-1	36,45	DHCR24	46,52	seladin-1	DHCR24	1718	1718	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Androgen_receptor regulation of the seladin-1 / DHCR24 gene : altered expression in prostate_cancer .
22512980	0	selenium-binding_protein_1	10,36	glutathione_peroxidase_1	46,70	selenium-binding protein 1	glutathione peroxidase 1	8991	2876	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|activity activity|amod|END_ENTITY	Decreased selenium-binding_protein_1 enhances glutathione_peroxidase_1 activity and downregulates HIF-1a to promote hepatocellular_carcinoma invasiveness .
19696890	0	selenocysteine_tRNA	49,68	Trsp	75,79	selenocysteine tRNA	Trsp	22069(Tax:10090)	22069(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Osteo-chondroprogenitor-specific deletion of the selenocysteine_tRNA gene , Trsp , leads to chondronecrosis and abnormal skeletal development : a putative model for Kashin-Beck_disease .
11568451	0	selenophosphate_synthetase	15,41	selD	43,47	selenophosphate synthetase	selD	36587(Tax:7227)	36587(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	The Drosophila selenophosphate_synthetase -LRB- selD -RRB- gene is required for development and cell proliferation .
26264612	0	selenoprotein_15-kDa	62,82	Sep15	84,89	selenoprotein 15-kDa	Sep15	9403	9403	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The 811_C / T polymorphism in the 3 ' untranslated region of the selenoprotein_15-kDa -LRB- Sep15 -RRB- gene and breast_cancer in Caucasian women .
26504085	0	selenoprotein_K	26,41	p97	53,56	selenoprotein K	p97	58515	7415	Gene	Gene	START_ENTITY|amod|binding binding|nmod|END_ENTITY	Selenoprotein_S-dependent selenoprotein_K binding to p97 -LRB- VCP -RRB- is essential for endoplasmic reticulum-associated degradation .
17661913	0	selenoprotein_S	16,31	SELS	33,37	selenoprotein S	SELS	55829	55829	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of the selenoprotein_S -LRB- SELS -RRB- gene -105 G > A promoter polymorphism in inflammatory_bowel_disease and regulation of SELS gene expression in intestinal inflammation .
20619427	0	selenoprotein_S	18,33	SELS	35,39	selenoprotein S	SELS	55829	55829	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the selenoprotein_S -LRB- SELS -RRB- gene in subcutaneous adipose tissue and SELS genotype are associated with metabolic risk factors .
20956524	0	selenoprotein_W	30,45	MyoD	49,53	selenoprotein W	MyoD	20364(Tax:10090)	17927(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of selenoprotein_W by MyoD during early skeletal muscle differentiation .
22311084	0	selenoprotein_W	26,41	SPS-1	109,114	selenoprotein W	SPS-1	100310814(Tax:9031)	426612(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of chicken selenoprotein_W , selenocysteine-synthase -LRB- SecS -RRB- , and selenophosphate_synthetase-1 -LRB- SPS-1 -RRB- in CHO-K1 cells .
26945060	0	semaphorin3A	25,37	PlexinA4	56,64	semaphorin3A	PlexinA4	10371	91584	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	TrkA mediates retrograde semaphorin3A signaling through PlexinA4 to regulate dendritic branching .
26945060	0	semaphorin3A	25,37	TrkA	0,4	semaphorin3A	TrkA	10371	4914	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	TrkA mediates retrograde semaphorin3A signaling through PlexinA4 to regulate dendritic branching .
11886873	0	semaphorin_3A	76,89	neuropilin-1	20,32	semaphorin 3A	neuropilin-1	537777(Tax:9913)	539369(Tax:9913)	Gene	Gene	binding|nmod|START_ENTITY confer|xcomp|binding features|acl:relcl|confer features|amod|END_ENTITY	Characterization of neuropilin-1 structural features that confer binding to semaphorin_3A and vascular endothelial growth factor 165 .
12456642	0	semaphorin_3A	79,92	neuropilin-1	38,50	semaphorin 3A	neuropilin-1	10371	8829	Gene	Gene	axonal|nmod|START_ENTITY axonal|nsubj|interactions interactions|nmod|L1 L1|nmod|control control|amod|END_ENTITY	Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin_3A .
24093675	0	semaphorin_3A	15,28	neuropilin-1	102,114	semaphorin 3A	neuropilin-1	10371	8829	Gene	Gene	inducer|nsubj|START_ENTITY inducer|nmod|permeability permeability|nmod|diabetic_retinopathy diabetic_retinopathy|nmod|END_ENTITY	Neuron-derived semaphorin_3A is an early inducer of vascular permeability in diabetic_retinopathy via neuropilin-1 .
24276892	0	semaphorin_3A	25,38	neuropilin-1	12,24	semaphorin 3A	neuropilin-1	10371	8829	Gene	Gene	signaling|nsubj|START_ENTITY role|parataxis|signaling role|nmod|END_ENTITY	The role of neuropilin-1 / semaphorin_3A signaling in lymphatic vessel development and maturation .
26723579	0	semaphorin_3B	88,101	Tumor_necrosis_factor_alpha	0,27	semaphorin 3B	Tumor necrosis factor alpha	7869	7124	Gene	Gene	inhibiting|dobj|START_ENTITY suppresses|advcl|inhibiting suppresses|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha suppresses osteogenic differentiation of MSCs by inhibiting semaphorin_3B via Wnt/b-catenin signaling in estrogen-deficiency induced osteoporosis .
19915008	0	semaphorin_3C	16,29	ADAMTS1	41,48	semaphorin 3C	ADAMTS1	10512	9510	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	The cleavage of semaphorin_3C induced by ADAMTS1 promotes cell migration .
16557299	0	semaphorin_3C	17,30	GATA-6	0,6	semaphorin 3C	GATA-6	10512	2627	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	GATA-6 regulates semaphorin_3C and is required in cardiac neural crest for cardiovascular morphogenesis .
21829538	0	semaphorin_3a	47,60	amyloid_precursor_protein	15,40	semaphorin 3a	amyloid precursor protein	10371	351	Gene	Gene	START_ENTITY|nsubj|binds binds|compound|END_ENTITY	Secreted human amyloid_precursor_protein binds semaphorin_3a and prevents semaphorin-induced growth cone collapse .
17213806	0	semaphorin_4B	21,34	CLCP1	0,5	semaphorin 4B	CLCP1	10509	266626	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CLCP1 interacts with semaphorin_4B and regulates motility of lung_cancer cells .
15218527	0	semaphorin_5A	39,52	Plexin-B3	0,9	semaphorin 5A	Plexin-B3	9037	5365	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Plexin-B3 is a functional receptor for semaphorin_5A .
16481103	0	semaphorin_5A	16,29	Sema5A	31,37	semaphorin 5A	Sema5A	9037	9037	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism in semaphorin_5A -LRB- Sema5A -RRB- gene is not a marker of Parkinson 's _ disease risk .
11350127	0	semaphorin_6B	6,19	SEMA6B	26,32	semaphorin 6B	SEMA6B	10501	10501	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	Human semaphorin_6B -LSB- -LRB- HSA -RRB- SEMA6B -RSB- , a novel human class 6 semaphorin gene : alternative splicing and all-trans-retinoic_acid-dependent downregulation in glioblastoma cell lines .
9856463	0	semaphorin_IV	31,44	Neuropilin-2	0,12	semaphorin IV	Neuropilin-2	6405	8828	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Neuropilin-2 is a receptor for semaphorin_IV : insight into the structural basis of receptor function and specificity .
22075473	0	semenogelin	52,63	EPPIN	41,46	semenogelin	EPPIN	6406	57119	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Loss of calcium in human spermatozoa via EPPIN , the semenogelin receptor .
8665956	0	semenogelin_II	20,34	prostate-specific_antigen	70,95	semenogelin II	prostate-specific antigen	6407	354	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of semenogelin_II and its molecular interaction with prostate-specific_antigen and protein_C_inhibitor .
10391401	0	semicarbazide-sensitive_amine_oxidase	16,53	SSAO	55,59	semicarbazide-sensitive amine oxidase	SSAO	314	314	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Elevated plasma semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity in Type_2_diabetes_mellitus complicated by retinopathy .
11042135	0	semicarbazide-sensitive_amine_oxidase	33,70	SSAO	72,76	semicarbazide-sensitive amine oxidase	SSAO	314	314	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Time-dependent activation of the semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- from ox lung microsomes .
12491790	0	semicarbazide-sensitive_amine_oxidase	76,113	SSAO	115,119	semicarbazide-sensitive amine oxidase	SSAO	314	314	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Various mammalian tissues contain cell membrane-bound amine oxidase termed semicarbazide-sensitive_amine_oxidase -LRB- SSAO , EC 1.4.3.6 -RRB- -RSB- .
14697907	0	semicarbazide-sensitive_amine_oxidase	39,76	SSAO	78,82	semicarbazide-sensitive amine oxidase	SSAO	314	314	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Selective inhibitors of membrane-bound semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity in mammalian tissues .
15456951	0	semicarbazide-sensitive_amine_oxidase	6,43	SSAO	45,49	semicarbazide-sensitive amine oxidase	SSAO	314	314	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Serum semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity correlates with VEGF in non-small-cell lung_cancer patients .
16487546	0	semicarbazide-sensitive_amine_oxidase	13,50	SSAO	52,56	semicarbazide-sensitive amine oxidase	SSAO	314	314	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Diabetes and semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity : a review .
16524643	0	semicarbazide-sensitive_amine_oxidase	8,45	SSAO	47,51	semicarbazide-sensitive amine oxidase	SSAO	29473(Tax:10116)	29473(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Soluble semicarbazide-sensitive_amine_oxidase -LRB- SSAO -RRB- activity is related to oxidative stress and subchronic_inflammation in streptozotocin-induced diabetic rats .
25572340	0	semicarbazide-sensitive_amine_oxidase	105,142	VAP-1	99,104	semicarbazide-sensitive amine oxidase	VAP-1	8639	8639	Gene	Gene	inhibition|amod|START_ENTITY inhibition|compound|END_ENTITY	Glitazones inhibit human monoamine oxidase but their anti-inflammatory actions are not mediated by VAP-1 / semicarbazide-sensitive_amine_oxidase inhibition .
20079884	0	semicarbazide-sensitive_amine_oxidase	53,90	elastin	36,43	semicarbazide-sensitive amine oxidase	elastin	8639	2006	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive_amine_oxidase in the context of its vascular-adhesion and tissue maturation functions .
12604697	0	semicarbazide-sensitive_amine_oxidase	14,51	tumor_necrosis_factor-alpha	66,93	semicarbazide-sensitive amine oxidase	tumor necrosis factor-alpha	11754(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of semicarbazide-sensitive_amine_oxidase expression by tumor_necrosis_factor-alpha in adipocytes : functional consequences on glucose transport .
10026171	0	seminal_vesicle_secretory_protein_II	106,142	megalin	69,76	seminal vesicle secretory protein II	megalin	25013(Tax:10116)	29216(Tax:10116)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	Identification of low_density_lipoprotein_receptor-related_protein-2 / megalin as an endocytic receptor for seminal_vesicle_secretory_protein_II .
18663494	0	senataxin	47,56	SETX	58,62	senataxin	SETX	23064	23064	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification and characterisation of a large senataxin -LRB- SETX -RRB- gene duplication in ataxia_with_ocular_apraxia_type_2 -LRB- AOA2 -RRB- .
15944925	0	senescence_marker_protein-30	36,64	SMP30	66,71	senescence marker protein-30	SMP30	19733(Tax:10090)	19733(Tax:10090)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of senescence_marker_protein-30 -LRB- SMP30 -RRB- in the submandibular gland and ultrastructural changes of the granular duct cells in SMP30 knockout mice .
19482009	0	senescence_marker_protein-30	51,79	SMP30	81,86	senescence marker protein-30	SMP30	19733(Tax:10090)	19733(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Effects of vitamin_C deficiency on the skin of the senescence_marker_protein-30 -LRB- SMP30 -RRB- knockout mouse .
11112409	0	sentrin	49,56	Daxx	15,19	sentrin	Daxx	7341	1616	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of Daxx , a Fas_binding_protein , with sentrin and Ubc9 .
11112409	0	sentrin	49,56	Fas_binding_protein	23,42	sentrin	Fas binding protein	7341	1616	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of Daxx , a Fas_binding_protein , with sentrin and Ubc9 .
22542101	0	separase	33,41	Kendrin	0,7	separase	Kendrin	9700	5116	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Kendrin is a novel substrate for separase involved in the licensing of centriole duplication .
11581162	0	separase	11,19	PIM	77,80	separase	PIM	38640(Tax:7227)	34404(Tax:7227)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Drosophila separase is required for sister chromatid separation and binds to PIM and THR .
11533655	0	separase	41,49	Slk19	79,84	separase	Slk19	852990(Tax:4932)	854370(Tax:4932)	Gene	Gene	cleavage|amod|START_ENTITY cleavage|nmod|END_ENTITY	Orchestrating anaphase and mitotic exit : separase cleavage and localization of Slk19 .
17974570	0	separase	78,86	cyclin_B1	37,46	separase	cyclin B1	9700	891	Gene	Gene	domain|nmod|START_ENTITY END_ENTITY|nmod|domain	Phosphorylation-dependent binding of cyclin_B1 to a Cdc6-like domain of human separase .
21782285	0	sepiapterin_reductase	8,29	PARK3	42,47	sepiapterin reductase	PARK3	6697	5072	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Role of sepiapterin_reductase gene at the PARK3 locus in Parkinson 's _ disease .
15241655	0	sepiapterin_reductase	51,72	SPR	79,82	sepiapterin reductase	SPR	6697	6697	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Heterozygous mutation in 5 ' - untranslated region of sepiapterin_reductase gene -LRB- SPR -RRB- in a patient with dopa-responsive_dystonia .
11241314	0	seprase	52,59	fibroblast_activation_protein	22,51	seprase	fibroblast activation protein	2191	2191	Gene	Gene	associated|nsubjpass|START_ENTITY expression|parataxis|associated expression|nmod|END_ENTITY	Stromal expression of fibroblast_activation_protein / seprase , a cell membrane serine proteinase and gelatinase , is associated with longer survival in patients with invasive_ductal_carcinoma of breast .
9247085	0	seprase	21,28	serine_integral_membrane_protease	32,65	seprase	serine integral membrane protease	2191	2191	Gene	Gene	cloning|nmod|START_ENTITY cloning|dep|END_ENTITY	Molecular cloning of seprase : a serine_integral_membrane_protease from human melanoma .
18938227	0	septin_4	135,143	dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A	28,89	septin 4	dual-specificity tyrosine phosphorylation-regulated kinase 1A	5414	1859	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	The Down syndrome candidate dual-specificity_tyrosine_phosphorylation-regulated_kinase_1A phosphorylates the neurodegeneration-related septin_4 .
20971078	0	sequestosome-1	31,45	WDFY3	95,100	sequestosome-1	WDFY3	8878	23001	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|END_ENTITY	Functional interaction between sequestosome-1 / p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts .
17002577	0	sequestosome_1	78,92	P62	93,96	sequestosome 1	P62	8878	8878	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Canine_distemper_virus induces human osteoclastogenesis through NF-kappaB and sequestosome_1 / P62 activation .
23147249	0	sequestosome_1	11,25	p62	26,29	sequestosome 1	p62	8878	8878	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for sequestosome_1 / p62 in mitochondrial dynamics , import and genome integrity .
23564079	0	sequestosome_1	45,59	p62	60,63	sequestosome 1	p62	8878	8878	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|dep|END_ENTITY	Bcl-2-dependent upregulation of autophagy by sequestosome_1 / p62 in vitro .
11593403	0	ser15	13,18	p53	47,50	ser15	p53	3190208(Tax:176280)	7157	Gene	Gene	modifications|amod|START_ENTITY Induction|nmod|modifications Induction|nmod|END_ENTITY	Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation .
12388539	1	serglycin	109,118	granzyme_B	93,103	serglycin	granzyme B	5552	3002	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of the macromolecular complex of granzyme_B with serglycin .
23070540	0	sericin-1	73,82	SGF-3	137,142	sericin-1	SGF-3	693057(Tax:7091)	693025(Tax:7091)	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Inhibition of the binding of MSG-intermolt-specific complex , MIC , to the sericin-1 gene promoter and sericin-1 gene expression by POU-M1 / SGF-3 .
18606591	0	serine-protease	27,42	Htra2	21,26	serine-protease	Htra2	2147	27429	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon_cancer cells .
17906693	0	serine-threonine_kinase_38	44,70	MEKK1/2	23,30	serine-threonine kinase 38	MEKK1/2	11329	4214;10746	Gene	Gene	signaling|nmod|START_ENTITY regulation|acl|signaling regulation|nmod|END_ENTITY	Negative regulation of MEKK1/2 signaling by serine-threonine_kinase_38 -LRB- STK38 -RRB- .
21148321	0	serine-threonine_kinase_receptor-associated_protein	27,78	B-MYB	0,5	serine-threonine kinase receptor-associated protein	B-MYB	11171	4605	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	B-MYB positively regulates serine-threonine_kinase_receptor-associated_protein -LRB- STRAP -RRB- activity through direct interaction .
21148321	0	serine-threonine_kinase_receptor-associated_protein	27,78	STRAP	80,85	serine-threonine kinase receptor-associated protein	STRAP	11171	11171	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	B-MYB positively regulates serine-threonine_kinase_receptor-associated_protein -LRB- STRAP -RRB- activity through direct interaction .
9247085	0	serine_integral_membrane_protease	32,65	seprase	21,28	serine integral membrane protease	seprase	2191	2191	Gene	Gene	cloning|dep|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning of seprase : a serine_integral_membrane_protease from human melanoma .
8921873	0	serine_palmitoyltransferase	108,135	Lcb2	92,96	serine palmitoyltransferase	Lcb2	189	9517	Gene	Gene	subunit|nmod|START_ENTITY subunit|amod|END_ENTITY	Sphingolipid synthesis : identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine_palmitoyltransferase .
2788607	0	serine_protease	54,69	CSPB	76,80	serine protease	CSPB	2147	3002	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and chromosomal assignment for a serine_protease gene -LRB- CSPB -RRB- expressed by human cytotoxic lymphocytes .
10786627	0	serine_protease	46,61	DISP	63,67	serine protease	DISP	50908(Tax:10090)	30943(Tax:10090)	Gene	Gene	Characterisation|nmod|START_ENTITY END_ENTITY|nsubj|Characterisation	Characterisation of a novel murine intestinal serine_protease , DISP .
20238298	0	serine_protease	17,32	HTRA1	8,13	serine protease	HTRA1	50908(Tax:10090)	56213(Tax:10090)	Gene	Gene	Role|appos|START_ENTITY Role|nmod|END_ENTITY	Role of HTRA1 , a serine_protease , in the progression of articular cartilage degeneration .
18786092	0	serine_protease	37,52	HtrA2	14,19	serine protease	HtrA2	2147	27429	Gene	Gene	START_ENTITY|nsubj|Activation Activation|nmod|END_ENTITY	Activation of HtrA2 , a mitochondrial serine_protease mediates apoptosis : current knowledge on HtrA2 mediated myocardial_ischemia / reperfusion injury .
2394468	0	serine_protease	20,35	IL-2	52,56	serine protease	IL-2	2147	3558	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|production production|compound|END_ENTITY	A chymotryptic-type serine_protease is required for IL-2 production by Jurkat T cells .
12147714	0	serine_protease	24,39	KLK8	52,56	serine protease	KLK8	2147	11202	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Epidermal expression of serine_protease , neuropsin -LRB- KLK8 -RRB- in normal and pathological skin samples .
20940292	0	serine_protease	51,66	KLK8	32,36	serine protease	KLK8	2147	11202	Gene	Gene	START_ENTITY|nsubj|Kallikrein-related_peptidase-8 Kallikrein-related_peptidase-8|appos|END_ENTITY	Kallikrein-related_peptidase-8 -LRB- KLK8 -RRB- is an active serine_protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade .
11215739	0	serine_protease	66,81	NS3	62,65	serine protease	NS3	2147	3845	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Mutations at vicinity of catalytic sites of hepatitis_C_virus NS3 serine_protease gene isolated from hepatocellular_carcinoma tissue .
15537383	0	serine_protease	22,37	PAR-2	58,63	serine protease	PAR-2	2147	2150	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The membrane-anchored serine_protease , TMPRSS2 , activates PAR-2 in prostate_cancer cells .
10095086	0	serine_protease	16,31	PRSS12	42,48	serine protease	PRSS12	50908(Tax:10090)	19142(Tax:10090)	Gene	Gene	START_ENTITY|appos|motopsin motopsin|nummod|END_ENTITY	Expression of a serine_protease -LRB- motopsin PRSS12 -RRB- mRNA in the mouse brain : in situ hybridization histochemical study .
16756256	0	serine_protease	40,55	PRSS12	67,73	serine protease	PRSS12	50908(Tax:10090)	19142(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of a motoneuron-specific serine_protease , motopsin -LRB- PRSS12 -RRB- , after facial_nerve_axotomy in mice .
9490672	0	serine_protease	66,81	STAT5beta	19,28	serine protease	STAT5beta	2147	6777	Gene	Gene	generated|nmod|START_ENTITY generated|nsubjpass|END_ENTITY	Carboxyl-truncated STAT5beta is generated by a nucleus-associated serine_protease in early hematopoietic progenitors .
12098703	0	serine_protease	65,80	Toll	25,29	serine protease	Toll	43545(Tax:7227)	43222(Tax:7227)	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of Drosophila Toll during fungal_infection by a blood serine_protease .
3924993	0	serine_protease	68,83	dipeptidyl_peptidase_II	93,116	serine protease	dipeptidyl peptidase II	292866(Tax:10116)	83799(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|dep|END_ENTITY	Cytochemical localization and biochemical evaluation of a lysosomal serine_protease in lung : dipeptidyl_peptidase_II in the normal rat .
2492450	0	serine_protease	32,47	easter	12,18	serine protease	easter	43545(Tax:7227)	41858(Tax:7227)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of easter , an apparent serine_protease , in organizing the dorsal-ventral pattern of the Drosophila embryo .
9094756	0	serine_protease	36,51	endothelin-1	18,30	serine protease	endothelin-1	2147	1906	Gene	Gene	Hydrolysis|nmod|START_ENTITY Hydrolysis|nmod|END_ENTITY	Hydrolysis of big endothelin-1 by a serine_protease in the membrane fraction of human lung .
17976375	0	serine_protease	48,63	nucleosome_releasing_factor	9,36	serine protease	nucleosome releasing factor	2147	55922	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	A plasma nucleosome_releasing_factor -LRB- NRF -RRB- with serine_protease activity is instrumental in removal of nucleosomes from secondary necrotic cells .
2258701	0	serine_protease	36,51	proteinase_3	20,32	serine protease	proteinase 3	2147	5657	Gene	Gene	Cloning|dep|START_ENTITY Cloning|nmod|END_ENTITY	Cloning of cDNA for proteinase_3 : a serine_protease , antibiotic , and autoantigen from human neutrophils .
15652673	0	serine_protease	2,17	serpin	29,35	serine protease	serpin	100008705(Tax:9986)	100009515(Tax:9986)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A serine_protease inhibitor -LRB- serpin -RRB- from Haemaphysalis longicornis as an anti-tick vaccine .
24831437	0	serine_protease_inhibitor_Kazal-type_5	18,56	TSLP	100,104	serine protease inhibitor Kazal-type 5	TSLP	11005	85480	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Epistasis between serine_protease_inhibitor_Kazal-type_5 -LRB- SPINK5 -RRB- and thymic_stromal_lymphopoietin -LRB- TSLP -RRB- genes contributes to childhood asthma .
15980664	0	serine_protease_inhibitor_Kazal_Type_1	17,55	SPINK1	57,63	serine protease inhibitor Kazal Type 1	SPINK1	6690	6690	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the serine_protease_inhibitor_Kazal_Type_1 -LRB- SPINK1 -RRB- gene in Japanese patients with pancreatitis .
26663388	0	serine_protease_inhibitor_Kazal_type_1	38,76	Interleukin-6	0,13	serine protease inhibitor Kazal type 1	Interleukin-6	6690	3569	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-6 increases expression of serine_protease_inhibitor_Kazal_type_1 through STAT3 in colorectal_adenocarcinoma .
20543535	0	serine_protease_inhibitor_Kazal_type_1	67,105	SPINK1	107,113	serine protease inhibitor Kazal type 1	SPINK1	6690	6690	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Phenotypic variability of the homozygous IVS3 +2 T > C mutation in the serine_protease_inhibitor_Kazal_type_1 -LRB- SPINK1 -RRB- gene in patients with chronic pancreatitis .
22673501	0	serine_protease_inhibitor_Kazal_type_1	21,59	SPINK1	61,67	serine protease inhibitor Kazal type 1	SPINK1	6690	6690	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The NS34 mutation of serine_protease_inhibitor_Kazal_type_1 -LRB- SPINK1 -RRB- gene and alcoholic_chronic_pancreatitis .
18386042	0	serine_protease_inhibitor_kazal_type_3	22,60	Spink3	62,68	serine protease inhibitor kazal type 3	Spink3	20730(Tax:10090)	20730(Tax:10090)	Gene	Gene	pattern|nmod|START_ENTITY pattern|appos|END_ENTITY	Expression pattern of serine_protease_inhibitor_kazal_type_3 -LRB- Spink3 -RRB- during mouse embryonic development .
9785760	0	serine_proteinase_inhibitor_2	44,73	Spi-2	75,80	serine proteinase inhibitor 2	Spi-2	24794(Tax:10116)	24794(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	One Lewis rat with homozygous defect of the serine_proteinase_inhibitor_2 -LRB- Spi-2 -RRB- gene and two Lewis rats with heterozygous Spi-2 gene defect .
7619083	0	serine_proteinase_inhibitor_3	22,51	interferon_gamma	60,76	serine proteinase inhibitor 3	interferon gamma	24795(Tax:10116)	25712(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Activation of the rat serine_proteinase_inhibitor_3 gene by interferon_gamma via the interleukin_6-responsive element .
22212898	0	serine_proteinase_inhibitor_Kazal-type_6	67,107	SPINK6	109,115	serine proteinase inhibitor Kazal-type 6	SPINK6	404203	404203	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression , purification and characterization of recombinant human serine_proteinase_inhibitor_Kazal-type_6 -LRB- SPINK6 -RRB- in Pichia_pastoris .
12622403	0	serotonin-2A_receptor	38,59	5-HT2A	66,72	serotonin-2A receptor	5-HT2A	3356	3356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Family-based association study of the serotonin-2A_receptor gene -LRB- 5-HT2A -RRB- and bipolar_disorder .
12167522	0	serotonin-2A_receptor	20,41	HTR2A	48,53	serotonin-2A receptor	HTR2A	3356	3356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the serotonin-2A_receptor gene -LRB- HTR2A -RRB- associated with childhood attention_deficit_hyperactivity_disorder -LRB- ADHD -RRB- in adult women with seasonal_affective_disorder .
26738766	0	serotonin_2A_receptor	46,67	HTR2A	74,79	serotonin 2A receptor	HTR2A	3356	3356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and expression of the human serotonin_2A_receptor gene -LRB- HTR2A -RRB- locus : identification of novel HTR2A and antisense -LRB- HTR2A-AS1 -RRB- exons .
20218802	0	serotonin_5-HT2A_receptor	20,45	DAT1	77,81	serotonin 5-HT2A receptor	DAT1	3356	6531	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interaction between serotonin_5-HT2A_receptor gene and dopamine_transporter -LRB- DAT1 -RRB- gene polymorphisms influences personality trait of persistence in Austrian Caucasians .
16697352	0	serotonin_5-HT2A_receptor	52,77	HTR2A	84,89	serotonin 5-HT2A receptor	HTR2A	3356	3356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the regulatory region of the human serotonin_5-HT2A_receptor gene -LRB- HTR2A -RRB- influence gene expression .
18006541	0	serotonin_5-HT2A_receptor	26,51	HTR2A	58,63	serotonin 5-HT2A receptor	HTR2A	3356	3356	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variations in the serotonin_5-HT2A_receptor gene -LRB- HTR2A -RRB- are associated with rheumatoid_arthritis .
8170356	0	serotonin_N-acetyltransferase	29,58	Nat-2	69,74	serotonin N-acetyltransferase	Nat-2	11298(Tax:10090)	17961(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The locus controlling pineal serotonin_N-acetyltransferase activity -LRB- Nat-2 -RRB- is located on mouse chromosome 11 .
12692162	0	serotonin_receptor_1A	45,66	htr1A	73,78	serotonin receptor 1A	htr1A	487230(Tax:9615)	487230(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the canine serotonin_receptor_1A gene -LRB- htr1A -RRB- .
16251523	0	serotonin_receptor_1A	95,116	htr1A	123,128	serotonin receptor 1A	htr1A	487230(Tax:9615)	487230(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and variation of three canine genes involved in serotonin binding and transport : the serotonin_receptor_1A gene -LRB- htr1A -RRB- , serotonin_receptor_2A gene -LRB- htr2A -RRB- , and serotonin transporter gene -LRB- slc6A4 -RRB- .
11247661	0	serotonin_receptor_1B	31,52	HTR1B	54,59	serotonin receptor 1B	HTR1B	3351	3351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic diversity of the human serotonin_receptor_1B -LRB- HTR1B -RRB- gene .
12437478	0	serotonin_receptor_1B	50,71	HTR1B	73,78	serotonin receptor 1B	HTR1B	3351	3351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA variation and psychopharmacology of the human serotonin_receptor_1B -LRB- HTR1B -RRB- gene .
14593427	0	serotonin_receptor_1B	57,78	HTR1B	80,85	serotonin receptor 1B	HTR1B	3351	3351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the 5 ' - untranslated region of the human serotonin_receptor_1B -LRB- HTR1B -RRB- gene affect gene expression .
14729271	0	serotonin_receptor_1B	45,66	htr1B	73,78	serotonin receptor 1B	htr1B	403741(Tax:9615)	403741(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the canine serotonin_receptor_1B gene -LRB- htr1B -RRB- .
16251523	0	serotonin_receptor_2A	131,152	htr2A	159,164	serotonin receptor 2A	htr2A	403882(Tax:9615)	403882(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and variation of three canine genes involved in serotonin binding and transport : the serotonin_receptor_1A gene -LRB- htr1A -RRB- , serotonin_receptor_2A gene -LRB- htr2A -RRB- , and serotonin transporter gene -LRB- slc6A4 -RRB- .
23774082	0	serotonin_receptor_2B	45,66	HTR2B	68,73	serotonin receptor 2B	HTR2B	3357	3357	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	No association between a polymorphism in the serotonin_receptor_2B -LRB- HTR2B -RRB- gene and personality traits in healthy Japanese subjects .
14557147	0	serotonin_receptor_3A	22,43	HTR3A	45,50	serotonin receptor 3A	HTR3A	3359	3359	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A polymorphism in the serotonin_receptor_3A -LRB- HTR3A -RRB- gene and its association with harm avoidance in women .
26631964	0	serotonin_reuptake_transporter	21,51	MicroRNA-24	0,11	serotonin reuptake transporter	MicroRNA-24	6532	407012	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	MicroRNA-24 inhibits serotonin_reuptake_transporter expression and aggravates irritable_bowel_syndrome .
12660809	0	serotonin_reuptake_transporter	30,60	SERT	62,66	serotonin reuptake transporter	SERT	6532	6532	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Ovarian steroid regulation of serotonin_reuptake_transporter -LRB- SERT -RRB- binding , distribution , and function in female macaques .
24246466	0	serotonin_transporter	34,55	5-HT1B_receptor	0,15	serotonin transporter	5-HT1B receptor	15567(Tax:10090)	15551(Tax:10090)	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	5-HT1B_receptor modulation of the serotonin_transporter in vivo : studies using KO mice .
20150867	0	serotonin_transporter	4,25	5-HTT	32,37	serotonin transporter	5-HTT	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The serotonin_transporter gene -LRB- 5-HTT -RRB- variant and psychiatric_disorders : review of current literature .
9603609	0	serotonin_transporter	78,99	5-HTT	106,111	serotonin transporter	5-HTT	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of a novel functional polymorphism within the promoter region of the serotonin_transporter gene -LRB- 5-HTT -RRB- in Brazilian patients affected by bipolar_disorder and schizophrenia .
10089017	0	serotonin_transporter	39,60	5-HTTLPR	62,70	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Neuroticism is not associated with the serotonin_transporter -LRB- 5-HTTLPR -RRB- polymorphism .
11343612	0	serotonin_transporter	85,106	5-HTTLPR	68,76	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	Obsessive-compulsive_disorder and the promoter region polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter gene -LRB- SLC6A4 -RRB- : a negative association study in the Afrikaner population .
12962916	0	serotonin_transporter	39,60	5-HTTLPR	98,106	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Despite the general correlation of the serotonin_transporter gene regulatory region polymorphism -LRB- 5-HTTLPR -RRB- and platelet serotonin concentration , lower platelet serotonin concentration in migraine patients is independent of the 5-HTTLPR variants .
14593433	0	serotonin_transporter	33,54	5-HTTLPR	16,24	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	A polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter promoter gene is associated with DSM-IV depression subtypes in seasonal_affective_disorder .
14966478	0	serotonin_transporter	47,68	5-HTTLPR	88,96	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	A meta-analysis of the association between the serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and trait anxiety .
15172105	0	serotonin_transporter	41,62	5-HTTLPR	69,77	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of evidence for association between serotonin_transporter gene -LRB- 5-HTTLPR -RRB- and obsessive-compulsive_disorder by case control and family association study in humans .
15691525	0	serotonin_transporter	83,104	5-HTTLPR	74,82	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|amod|END_ENTITY	The power of sample size and homogenous sampling : association between the 5-HTTLPR serotonin_transporter polymorphism and major_depressive_disorder .
17216342	0	serotonin_transporter	46,67	5-HTTLPR	87,95	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Family based association analyses between the serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and neuroticism , anxiety and depression .
17728423	0	serotonin_transporter	17,38	5-HTTLPR	53,61	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Association of a serotonin_transporter polymorphism -LRB- 5-HTTLPR -RRB- with depression , perceived stress , and norepinephrine in patients with coronary_disease : the Heart and Soul Study .
18628678	0	serotonin_transporter	21,42	5-HTTLPR	49,57	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Polymorphisms of the serotonin_transporter gene -LRB- 5-HTTLPR , A/G SNP in 5-HTTLPR , and STin2 VNTR -RRB- and their relation to personality traits in healthy individuals from Russia .
19125107	0	serotonin_transporter	43,64	5-HTTLPR	14,22	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|amod|END_ENTITY	Effect of the 5-HTTLPR polymorphism in the serotonin_transporter gene on major_depressive_disorder and related comorbid_disorders .
19209991	0	serotonin_transporter	24,45	5-HTTLPR	69,77	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Association between the serotonin_transporter promoter polymorphism -LRB- 5-HTTLPR -RRB- and adult unresolved attachment .
19252508	0	serotonin_transporter	37,58	5-HTTLPR	28,36	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|nummod|END_ENTITY	Possible association of the 5-HTTLPR serotonin_transporter promoter gene polymorphism with premature_ejaculation in a Turkish population .
19439997	0	serotonin_transporter	24,45	5-HTTLPR	52,60	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between the serotonin_transporter gene -LRB- 5-HTTLPR -RRB- and anger-related traits in Korean schizophrenic patients .
19531786	0	serotonin_transporter	24,45	5-HTTLPR	52,60	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Interaction between the serotonin_transporter gene -LRB- 5-HTTLPR -RRB- , stressful life events , and risk of depression : a meta-analysis .
19699062	0	serotonin_transporter	4,25	5-HTTLPR	45,53	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	The serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and affective symptoms among women diagnosed with borderline_personality_disorder .
20598814	0	serotonin_transporter	2,23	5-HTTLPR	38,46	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	A serotonin_transporter polymorphism -LRB- 5-HTTLPR -RRB- predicts the development of adolescent alcohol use .
21142930	0	serotonin_transporter	4,25	5-HTTLPR	52,60	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	The serotonin_transporter gene length polymorphism -LRB- 5-HTTLPR -RRB- and life events : no evidence for an interaction effect on neuroticism and anxious_depressive_symptoms .
21562513	0	serotonin_transporter	42,63	5-HTTLPR	25,33	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	Functional polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter gene is associated with subjective well-being : evidence from a US nationally representative sample .
22032950	0	serotonin_transporter	14,35	5-HTTLPR	37,45	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	impact|nmod|START_ENTITY impact|appos|END_ENTITY	The impact of serotonin_transporter -LRB- 5-HTTLPR -RRB- genotype on the development of resting-state functional connectivity in children and adolescents : a preliminary report .
22072907	0	serotonin_transporter	20,41	5-HTTLPR	56,64	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Modulation of human serotonin_transporter expression by 5-HTTLPR in colon cells .
23080078	0	serotonin_transporter	44,65	5-HTTLPR	85,93	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Relational security moderates the effect of serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- on stress generation and depression among adolescents .
23953022	0	serotonin_transporter	20,41	5-HTTLPR	61,69	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Working conditions , serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and anxiety_disorders : a prospective cohort study .
24015179	0	serotonin_transporter	31,52	5-HTTLPR	59,67	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|appos|END_ENTITY	A functional polymorphism in a serotonin_transporter gene -LRB- 5-HTTLPR -RRB- interacts with 9/11 to predict gun-carrying behavior .
24098925	0	serotonin_transporter	33,54	5-HTTLPR	4,12	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|amod|END_ENTITY	The 5-HTTLPR polymorphism in the serotonin_transporter gene moderates the association between emotional behavior and changes in marital satisfaction over time .
24512255	0	serotonin_transporter	4,25	5-HTTLPR	45,53	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	The serotonin_transporter gene polymorphism -LRB- 5-HTTLPR -RRB- and irritable_bowel_syndrome : a meta-analysis of 25 studies .
24842237	0	serotonin_transporter	49,70	5-HTTLPR	103,111	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Anxiety_disorders and anxiety-related_traits and serotonin_transporter gene-linked polymorphic region -LRB- 5-HTTLPR -RRB- in adolescents : case-control and trio studies .
25154585	0	serotonin_transporter	20,41	5-HTTLPR	74,82	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Interaction between serotonin_transporter gene-linked polymorphic region -LRB- 5-HTTLPR -RRB- and job-related stress in insomnia : a cross-sectional study in Sichuan , China .
26767356	0	serotonin_transporter	20,41	5-HTTLPR	48,56	serotonin transporter	5-HTTLPR	6532	6532	Gene	Gene	gene|compound|START_ENTITY Polymorphism|nmod|gene Polymorphism|appos|END_ENTITY	Polymorphism of the serotonin_transporter gene -LRB- 5-HTTLPR -RRB- in major depressive_disorder patients in Malaysia .
25481722	0	serotonin_transporter	15,36	5HTT	43,47	serotonin transporter	5HTT	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of serotonin_transporter gene -LRB- 5HTT -RRB- polymorphism and juvenile_myoclonic_epilepsy : a case-control study .
12090814	0	serotonin_transporter	20,41	5HTTLPR	70,77	serotonin transporter	5HTTLPR	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Association between serotonin_transporter gene promoter polymorphism -LRB- 5HTTLPR -RRB- and behavioral responses to tryptophan_depletion in healthy women with and without family history of depression .
21273531	0	serotonin_transporter	36,57	Epidermal_growth_factor	0,23	serotonin transporter	Epidermal growth factor	6532	1950	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Epidermal_growth_factor upregulates serotonin_transporter in human intestinal epithelial cells via transcriptional mechanisms .
25309082	0	serotonin_transporter	36,57	Epidermal_growth_factor	0,23	serotonin transporter	Epidermal growth factor	25553(Tax:10116)	25313(Tax:10116)	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Epidermal_growth_factor upregulates serotonin_transporter and its association with visceral_hypersensitivity in irritable_bowel_syndrome .
23410504	0	serotonin_transporter	16,37	IL-10	0,5	serotonin transporter	IL-10	6532	3586	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	IL-10 modulates serotonin_transporter activity and molecular expression in intestinal epithelial cells .
18581270	0	serotonin_transporter	51,72	M6B	22,25	serotonin transporter	M6B	6532	2824	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Membrane glycoprotein M6B interacts with the human serotonin_transporter .
16432527	0	serotonin_transporter	22,43	SERT	45,49	serotonin transporter	SERT	6532	6532	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Allelic expression of serotonin_transporter -LRB- SERT -RRB- mRNA in human pons : lack of correlation with the polymorphism SERTLPR .
21093224	0	serotonin_transporter	95,116	SERT	118,122	serotonin transporter	SERT	15567(Tax:10090)	15567(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Cerebral metabolic responses to 5-HT2A / C receptor activation in mice with genetically modified serotonin_transporter -LRB- SERT -RRB- expression .
21129470	0	serotonin_transporter	76,97	SERT	99,103	serotonin transporter	SERT	25553(Tax:10116)	25553(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Bacopa monniera leaf extract up-regulates tryptophan hydroxylase -LRB- TPH2 -RRB- and serotonin_transporter -LRB- SERT -RRB- expression : implications in memory formation .
23217646	0	serotonin_transporter	10,31	SERT	38,42	serotonin transporter	SERT	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Increased serotonin_transporter gene -LRB- SERT -RRB- DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood : a longitudinal study of discordant monozygotic twins .
24075737	0	serotonin_transporter	20,41	SERT	43,47	serotonin transporter	SERT	6532	6532	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association between serotonin_transporter -LRB- SERT -RRB- gene polymorphism and idiopathic_pulmonary_arterial_hypertension : a meta-analysis and review of the literature .
24138674	0	serotonin_transporter	27,48	SERT	50,54	serotonin transporter	SERT	6532	6532	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of platelet serotonin_transporter -LRB- SERT -RRB- in human obesity .
10771115	0	serotonin_transporter	59,80	SET	82,85	serotonin transporter	SET	6532	6532	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Involvement of the actin cytoskeleton in the regulation of serotonin_transporter -LRB- SET -RRB- activity : possible mechanism underlying SET regulation by protein kinase C .
10713891	0	serotonin_transporter	29,50	SLC6A4	52,58	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Refined mapping of the human serotonin_transporter -LRB- SLC6A4 -RRB- gene within 17q11 adjacent to the CPD and NF1 genes .
11343612	0	serotonin_transporter	85,106	SLC6A4	113,119	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Obsessive-compulsive_disorder and the promoter region polymorphism -LRB- 5-HTTLPR -RRB- in the serotonin_transporter gene -LRB- SLC6A4 -RRB- : a negative association study in the Afrikaner population .
16082508	0	serotonin_transporter	18,39	SLC6A4	46,52	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	No association of serotonin_transporter gene -LRB- SLC6A4 -RRB- with schizophrenia and bipolar_disorder in Japanese patients : association analysis based on linkage disequilibrium .
16820721	0	serotonin_transporter	103,124	SLC6A4	126,132	serotonin transporter	SLC6A4	100033848(Tax:9796)	100033848(Tax:9796)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism identification , RH mapping , and association analysis with the anxiety trait of the equine serotonin_transporter -LRB- SLC6A4 -RRB- gene .
18663369	0	serotonin_transporter	38,59	SLC6A4	66,72	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Panic_disorder is associated with the serotonin_transporter gene -LRB- SLC6A4 -RRB- but not the promoter region -LRB- 5-HTTLPR -RRB- .
18824000	0	serotonin_transporter	108,129	SLC6A4	96,102	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4 , the serotonin_transporter gene , which functions to influence all cellular serotonin systems .
18983505	0	serotonin_transporter	109,130	SLC6A4	102,108	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|compound|END_ENTITY	Effect of the selective serotonin reuptake inhibitor paroxetine on platelet function is modified by a SLC6A4 serotonin_transporter polymorphism .
20303273	0	serotonin_transporter	138,159	SLC6A4	166,172	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The association between personality , pain threshold and a single nucleotide polymorphism -LRB- rs3813034 -RRB- in the 3 ' - untranslated region of the serotonin_transporter gene -LRB- SLC6A4 -RRB- .
22311265	0	serotonin_transporter	17,38	SLC6A4	45,51	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Investigation of serotonin_transporter gene -LRB- SLC6A4 -RRB- by child_abuse history interaction with body mass index and diabetes_mellitus of White female depressed psychiatric inpatients .
22594806	0	serotonin_transporter	45,66	SLC6A4	73,79	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between a genetic variant in the serotonin_transporter gene -LRB- SLC6A4 -RRB- and suicidal behavior in patients with schizophrenia .
23630162	0	serotonin_transporter	31,52	SLC6A4	59,65	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Common and rare alleles of the serotonin_transporter gene , SLC6A4 , associated with Tourette 's _ disorder .
24069428	0	serotonin_transporter	2,23	SLC6A4	30,36	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	A serotonin_transporter gene -LRB- SLC6A4 -RRB- polymorphism is associated with reduced risk of irritable_bowel_syndrome in American and Asian population : a meta-analysis .
24392134	0	serotonin_transporter	21,42	SLC6A4	43,49	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Association study of serotonin_transporter SLC6A4 gene with Chinese_Han_irritable_bowel_syndrome .
26261165	0	serotonin_transporter	15,36	SLC6A4	38,44	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of serotonin_transporter -LRB- SLC6A4 -RRB- _ receptor -LRB- 5HTR1A , 5HTR2A -RRB- polymorphisms with response to treatment with escitalopram in patients with major_depressive_disorder : A preliminary study .
9672904	0	serotonin_transporter	44,65	SLC6A4	80,86	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Evidence for linkage disequilibrium between serotonin_transporter protein gene -LRB- SLC6A4 -RRB- and obsessive_compulsive_disorder .
9787878	0	serotonin_transporter	31,52	SLC6A4	69,75	serotonin transporter	SLC6A4	6532	6532	Gene	Gene	promoter|compound|START_ENTITY promoter|nmod|END_ENTITY	Functional polymorphism in the serotonin_transporter promoter at the SLC6A4 locus and mood_disorders .
23338678	0	serotonin_transporter	81,102	TNF-a	30,35	serotonin transporter	TNF-a	6532	7124	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	The pro-inflammatory cytokine TNF-a regulates the activity and expression of the serotonin_transporter -LRB- SERT -RRB- in astrocytes .
18363639	0	serotonin_transporter	16,37	Trypsinogen_IV	0,14	serotonin transporter	Trypsinogen IV	6532	5646	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Trypsinogen_IV , serotonin_transporter transcript levels and serotonin content are increased in small intestine of irritable_bowel_syndrome patients .
9322234	0	serotonin_transporter	53,74	hSERT	81,86	serotonin transporter	hSERT	6532	6532	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Association studies of bipolar_disorder at the human serotonin_transporter gene -LRB- hSERT ; 5HTT -RRB- .
7488148	0	serotonin_transporter	24,45	interleukin-1_beta	49,67	serotonin transporter	interleukin-1 beta	6532	3553	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the human serotonin_transporter by interleukin-1_beta .
11133008	0	serotonin_transporter	67,88	monoamine_oxidase_A	31,50	serotonin transporter	monoamine oxidase A	6532	4128	Gene	Gene	not|nmod|START_ENTITY expression|dep|not expression|nmod|END_ENTITY	The expression and activity of monoamine_oxidase_A , but not of the serotonin_transporter , is decreased in human placenta from pre-eclamptic pregnancies .
18429609	0	serotonin_transporter	19,40	norepinephrine_transporter	79,105	serotonin transporter	norepinephrine transporter	6532	6530	Gene	Gene	citalopram|compound|START_ENTITY citalopram|nmod|talopram talopram|compound|END_ENTITY	From the selective serotonin_transporter inhibitor citalopram to the selective norepinephrine_transporter inhibitor talopram : synthesis and structure-activity relationship studies .
21129446	0	serotonin_transporter	59,80	norepinephrine_transporter	23,49	serotonin transporter	norepinephrine transporter	15567(Tax:10090)	20538(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A greater role for the norepinephrine_transporter than the serotonin_transporter in murine nociception .
15634764	0	serotonin_transporter	73,94	p38_mitogen-activated_protein_kinase	11,47	serotonin transporter	p38 mitogen-activated protein kinase	6532	1432	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	A role for p38_mitogen-activated_protein_kinase in the regulation of the serotonin_transporter : evidence for distinct cellular mechanisms involved in transporter surface expression .
18321529	0	serotonin_transporter	20,41	prolactin	47,56	serotonin transporter	prolactin	6532	5617	Gene	Gene	START_ENTITY|nmod|response response|compound|END_ENTITY	Relationship of the serotonin_transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence .
16463401	0	serotonin_transporter	23,44	protein_kinase_A	57,73	serotonin transporter	protein kinase A	25553(Tax:10116)	25636(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	In vitro regulation of serotonin_transporter activity by protein_kinase_A and nicotinic acetylcholine receptors in the prefrontal cortex of rats .
12175857	0	serotonin_transporter	23,44	syntaxin_1A	8,19	serotonin transporter	syntaxin 1A	6532	6804	Gene	Gene	expression|compound|START_ENTITY Role|nmod|expression Role|nmod|END_ENTITY	Role of syntaxin_1A on serotonin_transporter expression in developing thalamocortical neurons .
20052688	0	serotonin_transporter	25,46	tryptophan_hydroxylase_1_and_2	48,78	serotonin transporter	tryptophan hydroxylase 1 and 2	6532	7166;121278	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|expression expression|amod|END_ENTITY	Simultaneous analysis of serotonin_transporter , tryptophan_hydroxylase_1_and_2 gene expression in the ventral prefrontal cortex of suicide victims .
22177971	0	serotonin_transporter_protein	21,50	SERT	52,56	serotonin transporter protein	SERT	6532	6532	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the serotonin_transporter_protein -LRB- SERT -RRB- gene in patients with pulmonary_arterial_hypertension .
15652673	0	serpin	29,35	serine_protease	2,17	serpin	serine protease	100009515(Tax:9986)	100008705(Tax:9986)	Gene	Gene	inhibitor|appos|START_ENTITY inhibitor|amod|END_ENTITY	A serine_protease inhibitor -LRB- serpin -RRB- from Haemaphysalis longicornis as an anti-tick vaccine .
22203995	0	serpinB2	66,74	TANK-binding_kinase_1	0,21	serpinB2	TANK-binding kinase 1	18788(Tax:10090)	56480(Tax:10090)	Gene	Gene	controls|nmod|START_ENTITY controls|nsubj|END_ENTITY	TANK-binding_kinase_1 -LRB- TBK1 -RRB- controls cell survival through PAI-2 / serpinB2 and transglutaminase_2 .
19956856	0	serpinB9	37,45	proteinase_inhibitor-9	14,36	serpinB9	proteinase inhibitor-9	5272	5272	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of proteinase_inhibitor-9 / serpinB9 in non-small_cell_lung_carcinoma cells and tissues .
15795238	0	serpina1	27,35	Serine_protease	0,15	serpina1	Serine protease	5265	2147	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Serine_protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization .
7780034	0	serum_amyloid_A	43,58	Ciliary_neurotrophic_factor	0,27	serum amyloid A	Ciliary neurotrophic factor	111345(Tax:10090)	12803(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Ciliary_neurotrophic_factor -LRB- CNTF -RRB- induces serum_amyloid_A , hypoglycaemia and anorexia , and potentiates IL-1 induced corticosterone and IL-6 production in mice .
14733913	0	serum_amyloid_A	65,80	IL-6	0,4	serum amyloid A	IL-6	6287	3569	Gene	Gene	induction|nmod|START_ENTITY role|nmod|induction plays|dobj|role plays|nsubj|END_ENTITY	IL-6 plays a critical role in the synergistic induction of human serum_amyloid_A -LRB- SAA -RRB- gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system .
25484067	0	serum_amyloid_A	69,84	IL-6	46,50	serum amyloid A	IL-6	111345(Tax:10090)	16193(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY secretion|amod|END_ENTITY	An affibody-adalimumab hybrid blocks combined IL-6 and TNF-triggered serum_amyloid_A secretion in vivo .
7790046	0	serum_amyloid_A	26,41	IL-6	51,55	serum amyloid A	IL-6	6287	3569	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Synergistic activation of serum_amyloid_A -LRB- SAA -RRB- by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line .
10487231	0	serum_amyloid_A	33,48	SAA	50,53	serum amyloid A	SAA	6287	6287	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of recombinant feline serum_amyloid_A -LRB- SAA -RRB- protein .
11298127	0	serum_amyloid_A	24,39	SAA	41,44	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Impaired degradation of serum_amyloid_A -LRB- SAA -RRB- protein by cytokine-stimulated monocytes .
12736442	0	serum_amyloid_A	21,36	SAA	38,41	serum amyloid A	SAA	678660(Tax:9685)	678660(Tax:9685)	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of feline serum_amyloid_A -LRB- SAA -RRB- as an inflammatory marker .
12874643	0	serum_amyloid_A	21,36	SAA	38,41	serum amyloid A	SAA	6287	6287	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	-LSB- Association between serum_amyloid_A -LRB- SAA -RRB- in salivary glands and high levels of circulating beta_2-microglobulin in patients with Sj gren syndrome -RSB- .
1720442	0	serum_amyloid_A	47,62	SAA	64,67	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A monoclonal antibody sandwich immunoassay for serum_amyloid_A -LRB- SAA -RRB- protein .
1995703	0	serum_amyloid_A	37,52	SAA	54,57	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	A solid phase enzyme immunoassay for serum_amyloid_A -LRB- SAA -RRB- protein .
20075072	0	serum_amyloid_A	16,31	SAA	33,36	serum amyloid A	SAA	6287	6287	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	CD36 is a novel serum_amyloid_A -LRB- SAA -RRB- receptor mediating SAA binding and SAA-induced signaling in human and rodent cells .
2017667	0	serum_amyloid_A	40,55	SAA	57,60	serum amyloid A	SAA	6287	6287	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Highly polymorphic domains of the human serum_amyloid_A -LRB- SAA -RRB- gene GSAA1 .
2502829	0	serum_amyloid_A	32,47	SAA	49,52	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The primary structure of equine serum_amyloid_A -LRB- SAA -RRB- protein .
3423742	0	serum_amyloid_A	27,42	SAA	44,47	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The amino_acid sequence of serum_amyloid_A -LRB- SAA -RRB- protein in mink .
7769239	0	serum_amyloid_A	56,71	SAA	73,76	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Quantification and mapping of antigenic determinants of serum_amyloid_A -LRB- SAA -RRB- protein utilizing sequence-specific immunoglobulins and Eu3 + as a specific probe for time-resolved fluorometric immunoassay .
7790046	0	serum_amyloid_A	26,41	SAA	43,46	serum amyloid A	SAA	6287	6287	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Synergistic activation of serum_amyloid_A -LRB- SAA -RRB- by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line .
7851899	0	serum_amyloid_A	94,109	SAA	111,114	serum amyloid A	SAA	6287	6287	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Use of somatic cell hybrids and fluorescence in situ hybridization to localize the functional serum_amyloid_A -LRB- SAA -RRB- genes to chromosome 11p15.4-p15 .1 and the entire SAA superfamily to chromosome 11p15 .
8188253	0	serum_amyloid_A	17,32	SAA	34,37	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Evolution of the serum_amyloid_A -LRB- SAA -RRB- protein superfamily .
8316768	0	serum_amyloid_A	35,50	SAA	52,55	serum amyloid A	SAA	6287	6287	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The revised amino_acid sequence of serum_amyloid_A -LRB- SAA -RRB- protein in mink .
9360966	0	serum_amyloid_A	13,28	SAA	30,33	serum amyloid A	SAA	6287	6287	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Induction of serum_amyloid_A -LRB- SAA -RRB- gene by SAA-activating sequence-binding factor -LRB- SAF -RRB- in monocyte/macrophage cells .
9472687	0	serum_amyloid_A	6,21	SAA	23,26	serum amyloid A	SAA	111345(Tax:10090)	111345(Tax:10090)	Gene	Gene	proteins|compound|START_ENTITY proteins|appos|END_ENTITY	Mouse serum_amyloid_A -LRB- SAA -RRB- proteins isolated by two-dimensional electrophoresis : characterization of isotypes and the effect of separate and combined administrations of cytokines , dexamethasone and lipopolysaccharide -LRB- LPS -RRB- on serum levels and isotype distribution .
7686132	0	serum_amyloid_A	141,156	SAA2	171,175	serum amyloid A	SAA2	6287	6289	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A constitutively expressed serum_amyloid_A protein gene -LRB- SAA4 -RRB- is closely linked to , and shares structural similarities with , an acute-phase serum_amyloid_A protein gene -LRB- SAA2 -RRB- .
1755958	0	serum_amyloid_A	27,42	SAA3	50,54	serum amyloid A	SAA3	6287	6290	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Nonexpression of the human serum_amyloid_A three -LRB- SAA3 -RRB- gene .
7686132	0	serum_amyloid_A	27,42	SAA4	57,61	serum amyloid A	SAA4	6287	6291	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A constitutively expressed serum_amyloid_A protein gene -LRB- SAA4 -RRB- is closely linked to , and shares structural similarities with , an acute-phase serum_amyloid_A protein gene -LRB- SAA2 -RRB- .
16236134	0	serum_amyloid_A	62,77	STAT3	18,23	serum amyloid A	STAT3	6287	6774	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum_amyloid_A gene expression .
18566366	0	serum_amyloid_A	60,75	TLR2	14,18	serum amyloid A	TLR2	6287	7097	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Cutting edge : TLR2 is a functional receptor for acute-phase serum_amyloid_A .
22622619	0	serum_amyloid_A	131,146	Toll-like_receptors_2_and_4	63,90	serum amyloid A	Toll-like receptors 2 and 4	6290	7097;7099	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Herpes_simplex_virus_type_1 induces simultaneous activation of Toll-like_receptors_2_and_4 and expression of the endogenous ligand serum_amyloid_A in astrocytes .
8006883	0	serum_amyloid_A	53,68	fibrinogen	97,107	serum amyloid A	fibrinogen	6287	2244	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	Synergism of interleukin_1 and interleukin_6 induces serum_amyloid_A production while depressing fibrinogen : a quantitative analysis .
24096654	0	serum_amyloid_A	44,59	interleukin-6	92,105	serum amyloid A	interleukin-6	6287	3569	Gene	Gene	synthesis|compound|START_ENTITY upregulates|dobj|synthesis upregulates|nmod|activation activation|nmod|END_ENTITY	Calcitonin_gene-related_peptide upregulates serum_amyloid_A synthesis through activation of interleukin-6 .
9933631	0	serum_amyloid_A	192,207	interleukin-6	175,188	serum amyloid A	interleukin-6	6287	3569	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Activation of Sp1 and its functional co-operation with serum_amyloid_A-activating sequence binding factor in synoviocyte cells trigger synergistic action of interleukin-1 and interleukin-6 in serum_amyloid_A gene expression .
12857601	0	serum_amyloid_A	56,71	interleukin-8	31,44	serum amyloid A	interleukin-8	6287	3576	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	mRNA expression and release of interleukin-8 induced by serum_amyloid_A in neutrophils and monocytes .
24842896	0	serum_amyloid_A	50,65	phospholipid_transfer_protein	82,111	serum amyloid A	phospholipid transfer protein	6287	5360	Gene	Gene	level|nmod|START_ENTITY level|nmod|END_ENTITY	Polycystic_ovary_syndrome influences the level of serum_amyloid_A and activity of phospholipid_transfer_protein in HDL and HDL .
19513118	0	serum_amyloid_A3	14,30	SAA3	32,36	serum amyloid A3	SAA3	20210(Tax:10090)	20210(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of serum_amyloid_A3 -LRB- SAA3 -RRB- in mouse colonic epithelium and adipose tissue by the intestinal microbiota .
14749357	0	serum_amyloid_A3	36,52	Tumor_necrosis_factor-alpha	0,27	serum amyloid A3	Tumor necrosis factor-alpha	20210(Tax:10090)	21926(Tax:10090)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces serum_amyloid_A3 in mouse granulosa cells .
15996754	0	serum_amyloid_A3	48,64	prolactin	116,125	serum amyloid A3	prolactin	281474(Tax:9913)	280901(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY stimulated|nsubj|expression stimulated|nmod|END_ENTITY	Differential expression and secretion of bovine serum_amyloid_A3 -LRB- SAA3 -RRB- by mammary epithelial cells stimulated with prolactin or lipopolysaccharide .
4086942	0	serum_amyloid_A_protein	11,34	SAA	36,39	serum amyloid A protein	SAA	6288	6288	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of serum_amyloid_A_protein -LRB- SAA -RRB- on composition , size , and density of high density lipoproteins in subjects with myocardial_infarction .
428149	0	serum_amyloid_A_protein	14,37	SAA	39,42	serum amyloid A protein	SAA	6288	6288	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of the serum_amyloid_A_protein -LRB- SAA -RRB- in normal persons of different age groups .
7775864	0	serum_amyloid_A_protein	39,62	SAA4	64,68	serum amyloid A protein	SAA4	6291	6291	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of constitutive human serum_amyloid_A_protein -LRB- SAA4 -RRB- as an apolipoprotein .
118839	0	serum_amyloid_P-component	11,36	SAP	38,41	serum amyloid P-component	SAP	325	325	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of serum_amyloid_P-component -LRB- SAP -RRB- by amyloid fibrils .
3143483	0	serum_amyloid_P-component	60,85	SAP	87,90	serum amyloid P-component	SAP	20219(Tax:10090)	20219(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY binding|appos|END_ENTITY	Receptor-mediated binding of the acute-phase reactant mouse serum_amyloid_P-component -LRB- SAP -RRB- to macrophages .
4054960	0	serum_amyloid_P-component	6,31	SAP	33,36	serum amyloid P-component	SAP	20219(Tax:10090)	20219(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Mouse serum_amyloid_P-component -LRB- SAP -RRB- levels controlled by a locus on chromosome 1 .
6600258	2	serum_amyloid_P-component	56,81	SAP	83,86	serum amyloid P-component	SAP	20219(Tax:10090)	20219(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Strain dependence of serum_amyloid_P-component -LRB- SAP -RRB- levels and response to inflammation .
3759147	0	serum_amyloid_P_component	44,69	APCS	76,80	serum amyloid P component	APCS	325	325	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human C-reactive_protein gene -LRB- CRP -RRB- and serum_amyloid_P_component gene -LRB- APCS -RRB- are located on the proximal long arm of chromosome 1 .
6467904	0	serum_amyloid_a_protein	23,46	SAA	48,51	serum amyloid a protein	SAA	6288	6288	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A comparative study of serum_amyloid_a_protein -LRB- SAA -RRB- from mink and man .
15871460	0	serum_and_glucocorticoid-inducible_kinase-like_kinase	18,71	Sgkl	73,77	serum and glucocorticoid-inducible kinase-like kinase	Sgkl	27219(Tax:10090)	27219(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A mutation in the serum_and_glucocorticoid-inducible_kinase-like_kinase -LRB- Sgkl -RRB- gene is associated with defective hair growth in mice .
18614997	0	serum_and_glucocorticoid-inducible_kinase_1	73,116	CLC-K1	61,67	serum and glucocorticoid-inducible kinase 1	CLC-K1	20393(Tax:10090)	12733(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY induces|nmod|pathway induces|dobj|END_ENTITY	High osmolality induces the kidney-specific chloride channel CLC-K1 by a serum_and_glucocorticoid-inducible_kinase_1 MAPK pathway .
11335130	0	serum_and_glucocorticoid-inducible_protein_kinase	62,111	Sgk	113,116	serum and glucocorticoid-inducible protein kinase	Sgk	20393(Tax:10090)	20393(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Tissue-specific expression of the transcriptionally regulated serum_and_glucocorticoid-inducible_protein_kinase -LRB- Sgk -RRB- during mouse embryogenesis .
15576372	0	serum_and_glucocorticoid-regulated_kinase	32,73	SGK	75,78	serum and glucocorticoid-regulated kinase	SGK	6446	6446	Gene	Gene	ubiquitination|amod|START_ENTITY ubiquitination|appos|END_ENTITY	Nedd4-2 phosphorylation induces serum_and_glucocorticoid-regulated_kinase -LRB- SGK -RRB- ubiquitination and degradation .
10996431	0	serum_and_glucocorticoid-regulated_kinase	22,63	sgk	65,68	serum and glucocorticoid-regulated kinase	sgk	6446	6446	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Rapid upregulation of serum_and_glucocorticoid-regulated_kinase -LRB- sgk -RRB- gene expression by corticosteroids in vivo .
15107590	0	serum_and_glucocorticoid_regulated_kinase	19,60	sgk1	62,66	serum and glucocorticoid regulated kinase	sgk1	6446	6446	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the serum_and_glucocorticoid_regulated_kinase -LRB- sgk1 -RRB- gene with QT interval .
3958137	0	serum_carboxypeptidase_N	23,47	SCPN	49,53	serum carboxypeptidase N	SCPN	1369	1369	Gene	Gene	synthesis|nmod|START_ENTITY synthesis|appos|END_ENTITY	Decreased synthesis of serum_carboxypeptidase_N -LRB- SCPN -RRB- in familial SCPN_deficiency .
10330138	0	serum_response_factor	41,62	Basic_fibroblast_growth_factor	0,30	serum response factor	Basic fibroblast growth factor	6722	2247	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor activates serum_response_factor gene expression by multiple distinct signaling mechanisms .
9388250	0	serum_response_factor	51,72	CREB-binding_protein	4,24	serum response factor	CREB-binding protein	6722	1387	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	The CREB-binding_protein -LRB- CBP -RRB- cooperates with the serum_response_factor for transactivation of the c-fos serum response element .
2200737	0	serum_response_factor	54,75	Casein_kinase_II	0,16	serum response factor	Casein kinase II	6722	1457	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Casein_kinase_II enhances the DNA binding activity of serum_response_factor .
12955073	0	serum_response_factor	14,35	CrkII	0,5	serum response factor	CrkII	20807(Tax:10090)	12928(Tax:10090)	Gene	Gene	activation|compound|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	CrkII induces serum_response_factor activation and cellular transformation through its function in Rho activation .
19359245	0	serum_response_factor	30,51	Enhancer_of_polycomb1	0,21	serum response factor	Enhancer of polycomb1	20807(Tax:10090)	13831(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Enhancer_of_polycomb1 acts on serum_response_factor to regulate skeletal muscle differentiation .
23946491	0	serum_response_factor	40,61	Foxf1	25,30	serum response factor	Foxf1	20807(Tax:10090)	15227(Tax:10090)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	The transcription factor Foxf1 binds to serum_response_factor and myocardin to regulate gene transcription in visceral smooth muscle cells .
16456537	0	serum_response_factor	60,81	H-Ras	95,100	serum response factor	H-Ras	20807(Tax:10090)	15461(Tax:10090)	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Suppression of Egr-1 transcription through targeting of the serum_response_factor by oncogenic H-Ras .
10318869	0	serum_response_factor	31,52	MAPKAP_kinase_2	0,15	serum response factor	MAPKAP kinase 2	20807(Tax:10090)	17164(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	MAPKAP_kinase_2 phosphorylates serum_response_factor in vitro and in vivo .
25868726	0	serum_response_factor	17,38	Malat1	0,6	serum response factor	Malat1	20807(Tax:10090)	72289(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Malat1 regulates serum_response_factor through miR-133 as a competing endogenous RNA in myogenesis .
12039949	0	serum_response_factor	17,38	RhoA	111,115	serum response factor	RhoA	20807(Tax:10090)	11848(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY regulated|nsubjpass|activity regulated|nmod|signaling signaling|compound|END_ENTITY	High activity of serum_response_factor in the mesenchymal transition of epithelial_tumor cells is regulated by RhoA signaling .
9804789	0	serum_response_factor	19,40	RhoA	0,4	serum response factor	RhoA	20807(Tax:10090)	11848(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY signaling|compound|END_ENTITY	RhoA signaling via serum_response_factor plays an obligatory role in myogenic differentiation .
19783823	0	serum_response_factor	53,74	SMYD1	0,5	serum response factor	SMYD1	20807(Tax:10090)	12180(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	SMYD1 , the myogenic activator , is a direct target of serum_response_factor and myogenin .
21329726	0	serum_response_factor	11,32	SRF	34,37	serum response factor	SRF	20807(Tax:10090)	20807(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of serum_response_factor -LRB- SRF -RRB- deletion on conditioned reinforcement .
18035064	0	serum_response_factor	22,43	TGF-beta	0,8	serum response factor	TGF-beta	6722	7040	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	TGF-beta up-regulates serum_response_factor in activated hepatic stellate cells .
19151320	0	serum_response_factor	17,38	TGF-beta	93,101	serum response factor	TGF-beta	6722	7040	Gene	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|END_ENTITY	Critical role of serum_response_factor in pulmonary myofibroblast differentiation induced by TGF-beta .
7565750	0	serum_response_factor	35,56	YY1	0,3	serum response factor	YY1	20807(Tax:10090)	22632(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY facilitates|dobj|association facilitates|nsubj|END_ENTITY	YY1 facilitates the association of serum_response_factor with the c-fos serum response element .
10777594	0	serum_response_factor	16,37	c-FOS	110,115	serum response factor	c-FOS	6722	2353	Gene	Gene	Cleavage|nmod|START_ENTITY results|nsubj|Cleavage results|nmod|inhibition inhibition|nmod|activity activity|amod|END_ENTITY	Cleavage of the serum_response_factor during death receptor-induced apoptosis results in an inhibition of the c-FOS promoter transcriptional activity .
2845402	0	serum_response_factor	19,40	c-FOS	99,104	serum response factor	c-FOS	6722	2353	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|factor factor|acl:relcl|binds binds|nmod|element element|nmod|enhancer enhancer|amod|END_ENTITY	Phosphorylation of serum_response_factor , a factor that binds to the serum response element of the c-FOS enhancer .
12051724	0	serum_response_factor	107,128	c-fos	23,28	serum response factor	c-fos	6722	2353	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum_response_factor in MCF-7 breast_cancer cells .
1328862	0	serum_response_factor	80,101	c-fos	33,38	serum response factor	c-fos	6722	2353	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|stimulation stimulation|nmod|element element|amod|END_ENTITY	Maximal serum stimulation of the c-fos serum response element requires both the serum_response_factor and a novel binding factor , SRE-binding protein .
2169025	0	serum_response_factor	61,82	c-fos	14,19	serum response factor	c-fos	6722	2353	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|transcription transcription|amod|END_ENTITY	Inhibition of c-fos transcription and phosphorylation of the serum_response_factor by an inhibitor of phospholipase C-type reactions .
2493627	0	serum_response_factor	45,66	c-fos	39,44	serum response factor	c-fos	6722	2353	Gene	Gene	site|compound|START_ENTITY site|compound|END_ENTITY	Point mutational analysis of the human c-fos serum_response_factor binding site .
7565750	0	serum_response_factor	35,56	c-fos	66,71	serum response factor	c-fos	20807(Tax:10090)	14281(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY facilitates|dobj|association facilitates|nmod|element element|amod|END_ENTITY	YY1 facilitates the association of serum_response_factor with the c-fos serum response element .
9388250	0	serum_response_factor	51,72	c-fos	100,105	serum response factor	c-fos	6722	2353	Gene	Gene	START_ENTITY|nmod|transactivation transactivation|nmod|element element|amod|END_ENTITY	The CREB-binding_protein -LRB- CBP -RRB- cooperates with the serum_response_factor for transactivation of the c-fos serum response element .
21984848	0	serum_response_factor	132,153	myocardin	154,163	serum response factor	myocardin	6722	93649	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	Transforming_growth_factor-b1-induced_transcript_1 protein , a novel marker for smooth muscle contractile phenotype , is regulated by serum_response_factor / myocardin protein .
8670842	0	serum_response_factor	18,39	p65/NF-kappaB	43,56	serum response factor	p65/NF-kappaB	6722	5970;4790	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of the serum_response_factor by p65/NF-kappaB .
9314842	0	serum_response_factor	78,99	smooth_muscle_alpha-actin	38,63	serum response factor	smooth muscle alpha-actin	501099(Tax:10116)	81633(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Angiotensin_II-induced stimulation of smooth_muscle_alpha-actin expression by serum_response_factor and the homeodomain transcription factor MHox .
22385615	0	serum_response_factor	30,51	tip	88,91	serum response factor	tip	6722	261726	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Actin-dependent activation of serum_response_factor in T cells by the viral oncoprotein tip .
6207196	0	serum_spreading_factor	6,28	somatomedin_B	46,59	serum spreading factor	somatomedin B	7448	7448	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Human serum_spreading_factor : relationship to somatomedin_B .
23959424	0	sestrin-2	16,25	P53	41,44	sestrin-2	P53	83667	7157	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of sestrin-2 expression via P53 protects against 1-methyl-4-phenylpyridinium -LRB- MPP + -RRB- neurotoxicity .
16752048	0	seven_in_absentia_homolog_1	25,52	SIAH1	54,59	seven in absentia homolog 1	SIAH1	6477	6477	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation analysis of the seven_in_absentia_homolog_1 -LRB- SIAH1 -RRB- gene in Parkinson 's _ disease .
8239073	0	sex-determining_region_Y	4,28	SRY	30,33	sex-determining region Y	SRY	100625818	100625818	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The sex-determining_region_Y -LRB- SRY -RRB- gene is mapped to p12-p13 of the Y chromosome in pig -LRB- Sus_scrofa_domestica -RRB- by in situ hybridization .
8434602	0	sex-determining_region_Y	104,128	SRY	130,133	sex-determining region Y	SRY	6736	6736	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the transcriptional unit , structural organization , and promoter sequence of the human sex-determining_region_Y -LRB- SRY -RRB- gene , using a reverse genetic approach .
25291942	0	sex-determining_region_Y-box_17	28,59	SOX17	61,66	sex-determining region Y-box 17	SOX17	64321	64321	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Abnormal methylation of the sex-determining_region_Y-box_17 -LRB- SOX17 -RRB- promoter predicts poor prognosis in myelodysplastic_syndrome .
10428169	0	sex-determining_region_on_Y	8,35	SRY	37,40	sex-determining region on Y	SRY	6736	6736	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A novel sex-determining_region_on_Y -LRB- SRY -RRB- nonsense mutation identified in a 45 , X/47 , XYY female .
9093193	0	sex-determining_region_on_Y	47,74	SRY	76,79	sex-determining region on Y	SRY	6736	6736	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Paternal somatic and germ-line mosaicism for a sex-determining_region_on_Y -LRB- SRY -RRB- missense mutation leading to recurrent 46 , XY sex reversal .
1483288	0	sex-hormone-binding_globulin	47,75	SHBG	77,81	sex-hormone-binding globulin	SHBG	6462	6462	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Subtle changes in serum thyrotrophin -LRB- TSH -RRB- and sex-hormone-binding_globulin -LRB- SHBG -RRB- levels during long-term follow-up after radioactive_iodine in multinodular non-toxic goitre .
12645926	0	sex-lethal	24,34	Antizyme	0,8	sex-lethal	Antizyme	3772180(Tax:7227)	36307(Tax:7227)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin_B .
12645926	0	sex-lethal	116,126	hedgehog	95,103	sex-lethal	hedgehog	3772180(Tax:7227)	42737(Tax:7227)	Gene	Gene	regulate|dobj|START_ENTITY END_ENTITY|xcomp|regulate	Antizyme is a target of sex-lethal in the Drosophila germline and appears to act downstream of hedgehog to regulate sex-lethal and cyclin_B .
3998475	0	sex-limited_protein	22,41	SLP	43,46	sex-limited protein	SLP	625018(Tax:10090)	625018(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mice constitutive for sex-limited_protein -LRB- SLP -RRB- expression contain multiple Slp gene sequences .
10521447	0	sex-limited_protein	89,108	Slp	110,113	sex-limited protein	Slp	625018(Tax:10090)	625018(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited_protein -LRB- Slp -RRB- gene .
7877972	0	sex-limited_protein	65,84	Slp	60,63	sex-limited protein	Slp	625018(Tax:10090)	625018(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Sexually dimorphic DNA demethylation in the promoter of the Slp -LRB- sex-limited_protein -RRB- gene in mouse liver .
9286679	0	sex-peptide	28,39	Acp70A	41,47	sex-peptide	Acp70A	39494(Tax:7227)	39494(Tax:7227)	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Evolutionary history of the sex-peptide -LRB- Acp70A -RRB- gene region in Drosophila_melanogaster .
9573377	0	sex-peptide	4,15	Acp70A	22,28	sex-peptide	Acp70A	39494(Tax:7227)	39494(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The sex-peptide gene -LRB- Acp70A -RRB- is duplicated in Drosophila subobscura .
9718726	0	sex-peptide	42,53	Acp70A	55,61	sex-peptide	Acp70A	39494(Tax:7227)	39494(Tax:7227)	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Molecular evolution of a duplication : the sex-peptide -LRB- Acp70A -RRB- gene region of Drosophila subobscura and Drosophila madeirensis .
25986942	0	sex_determining_region_Y-box_2	91,121	Akt	70,73	sex determining region Y-box 2	Akt	499593(Tax:10116)	24185(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|amod|END_ENTITY	In oesophageal squamous cells , nitric_oxide causes S-nitrosylation of Akt and blocks SOX2 -LRB- sex_determining_region_Y-box_2 -RRB- expression .
25986942	0	sex_determining_region_Y-box_2	91,121	SOX2	85,89	sex determining region Y-box 2	SOX2	499593(Tax:10116)	499593(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	In oesophageal squamous cells , nitric_oxide causes S-nitrosylation of Akt and blocks SOX2 -LRB- sex_determining_region_Y-box_2 -RRB- expression .
22902540	0	sex_hormone-binding_globulin	24,52	HNF-4a	78,84	sex hormone-binding globulin	HNF-4a	6462	3172	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	IL1b down-regulation of sex_hormone-binding_globulin production by decreasing HNF-4a via MEK-1 / 2 and JNK MAPK pathways .
14671199	0	sex_hormone-binding_globulin	55,83	SHBG	85,89	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the -LRB- TAAAA -RRB- n repeat polymorphism in the sex_hormone-binding_globulin -LRB- SHBG -RRB- gene with polycystic_ovary_syndrome and relation to SHBG serum levels .
15149727	0	sex_hormone-binding_globulin	14,42	SHBG	44,48	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of sex_hormone-binding_globulin -LRB- SHBG -RRB- in human granulosa-lutein cells .
15807883	0	sex_hormone-binding_globulin	16,44	SHBG	46,50	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of sex_hormone-binding_globulin -LRB- SHBG -RRB- are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men .
16028066	0	sex_hormone-binding_globulin	22,50	SHBG	52,56	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of sex_hormone-binding_globulin -LRB- SHBG -RRB- in human ovarian follicles and corpus luteum .
19679209	0	sex_hormone-binding_globulin	32,60	SHBG	62,66	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of polymorphisms of the sex_hormone-binding_globulin -LRB- SHBG -RRB- gene on free estradiol and bone_mineral_density .
20974254	0	sex_hormone-binding_globulin	70,98	SHBG	100,104	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the -LRB- TAAAA -RRB- n repeat and Asp327Asn polymorphisms in the sex_hormone-binding_globulin -LRB- SHBG -RRB- gene with idiopathic_male_infertility and relation to serum SHBG concentrations .
2106280	0	sex_hormone-binding_globulin	10,38	SHBG	40,44	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	Assay|nmod|START_ENTITY Assay|appos|END_ENTITY	-LSB- Assay of sex_hormone-binding_globulin -LRB- SHBG -RRB- in human serum .
23001781	0	sex_hormone-binding_globulin	23,51	SHBG	58,62	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common variants in the sex_hormone-binding_globulin gene -LRB- SHBG -RRB- and polycystic_ovary_syndrome -LRB- PCOS -RRB- in Mediterranean women .
7505768	0	sex_hormone-binding_globulin	75,103	SHBG	105,109	sex hormone-binding globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of a MspI restriction fragment length polymorphism for the human sex_hormone-binding_globulin -LRB- SHBG -RRB- gene .
9002628	0	sex_hormone-binding_globulin	56,84	androgen-binding_protein	31,55	sex hormone-binding globulin	androgen-binding protein	20415(Tax:10090)	11354(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression and distribution of androgen-binding_protein / sex_hormone-binding_globulin in the female rodent reproductive system .
22210320	0	sex_hormone-binding_globulin	60,88	tumor_necrosis_factor-a	18,41	sex hormone-binding globulin	tumor necrosis factor-a	6462	7124	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of tumor_necrosis_factor-a in downregulating sex_hormone-binding_globulin .
1637726	0	sex_hormone_binding_globulin	15,43	SHBG	45,49	sex hormone binding globulin	SHBG	6462	6462	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of sex_hormone_binding_globulin -LRB- SHBG -RRB- on testosterone transport into the cerebrospinal fluid .
18056923	0	sex_hormone_binding_globulin	22,50	SHBG	52,56	sex hormone binding globulin	SHBG	6462	6462	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Associations of serum sex_hormone_binding_globulin -LRB- SHBG -RRB- levels with SHBG gene polymorphisms in the CARDIA Male Hormone Study .
1958578	0	sex_hormone_binding_globulin	11,39	SHBG	41,45	sex hormone binding globulin	SHBG	6462	6462	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of sex_hormone_binding_globulin -LRB- SHBG -RRB- on human prostatic_carcinoma .
19933169	0	sex_hormone_binding_globulin	29,57	SHBG	59,63	sex hormone binding globulin	SHBG	6462	6462	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Genetic evidence that raised sex_hormone_binding_globulin -LRB- SHBG -RRB- levels reduce the risk of type 2 diabetes .
2391961	0	sex_hormone_binding_globulin	24,52	SHBG	54,58	sex hormone binding globulin	SHBG	6462	6462	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Direct effect of plasma sex_hormone_binding_globulin -LRB- SHBG -RRB- on the metabolic clearance rate of 17_beta-estradiol in the primate .
24456771	0	sex_hormone_binding_globulin	16,44	SHBG	46,50	sex hormone binding globulin	SHBG	6462	6462	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of sex_hormone_binding_globulin -LRB- SHBG -RRB- are not predictive of prostate_cancer diagnosis and aggressiveness : results from an Italian biopsy cohort .
3747520	0	sex_steroid_binding_protein	34,61	SBP	63,66	sex steroid binding protein	SBP	100009224(Tax:9986)	100009224(Tax:9986)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Molecular characterization of the sex_steroid_binding_protein -LRB- SBP -RRB- of plasma .
8647846	0	sgk	40,43	p53	0,3	sgk	p53	29517(Tax:10116)	301300(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	p53 stimulates promoter activity of the sgk .
10996431	0	sgk	65,68	serum_and_glucocorticoid-regulated_kinase	22,63	sgk	serum and glucocorticoid-regulated kinase	6446	6446	Gene	Gene	upregulation|appos|START_ENTITY upregulation|nmod|END_ENTITY	Rapid upregulation of serum_and_glucocorticoid-regulated_kinase -LRB- sgk -RRB- gene expression by corticosteroids in vivo .
15107590	0	sgk1	62,66	serum_and_glucocorticoid_regulated_kinase	19,60	sgk1	serum and glucocorticoid regulated kinase	6446	6446	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Association of the serum_and_glucocorticoid_regulated_kinase -LRB- sgk1 -RRB- gene with QT interval .
25823168	0	sglt2	30,35	Sodium_glucose_transporter_2	0,28	sglt2	Sodium glucose transporter 2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|amod|END_ENTITY	Sodium_glucose_transporter_2 -LRB- sglt2 -RRB- inhibitors : Current status in clinical practice .
17251388	0	sh2d4a	95,101	dendrin	80,87	sh2d4a	dendrin	72281(Tax:10090)	13199(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	sh2d4a	95,101	ehd3	89,93	sh2d4a	ehd3	72281(Tax:10090)	57440(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
17251388	0	sh2d4a	95,101	plekhh2	103,110	sh2d4a	plekhh2	72281(Tax:10090)	213556(Tax:10090)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Expression and subcellular distribution of novel glomerulus-associated proteins dendrin , ehd3 , sh2d4a , plekhh2 , and 2310066E14Rik .
22367317	0	shadow_of_prion_protein_homology	23,55	SPRN	17,21	shadow of prion protein homology	SPRN	100302330(Tax:9940)	100302330(Tax:9940)	Gene	Gene	Polymorphisms|appos|START_ENTITY Polymorphisms|nmod|END_ENTITY	Polymorphisms of SPRN -LRB- shadow_of_prion_protein_homology -RRB- in three breeds of sheep in China .
8774437	0	shal	41,45	shal	8,12	shal	shal	40129(Tax:7227)	40129(Tax:7227)	Gene	Gene	comparison|nmod|START_ENTITY END_ENTITY|dep|comparison	Lobster shal : comparison with Drosophila shal and native potassium currents in identified neurons .
8774437	0	shal	8,12	shal	41,45	shal	shal	40129(Tax:7227)	40129(Tax:7227)	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Lobster shal : comparison with Drosophila shal and native potassium currents in identified neurons .
12504591	0	shank1	57,63	IRSp53	31,37	shank1	IRSp53	50944	10458	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42 .
7748792	0	shavenbaby	144,154	ovo	0,3	shavenbaby	ovo	31429(Tax:7227)	31429(Tax:7227)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	ovo , a Drosophila gene required for ovarian development , is specifically expressed in the germline and shares most of its coding sequences with shavenbaby , a gene involved in embryo patterning .
18191273	6	shc	858,861	p66	854,857	shc	p66	20416(Tax:10090)	20416(Tax:10090)	Gene	Gene	results|appos|START_ENTITY results|amod|END_ENTITY	These data suggest that prevention of apoptosis conferred by ablation of p66 -LRB- shc -RRB- results from changed ROS-scavenging , but not inhibition of ROS generation .
21439852	0	shc	25,28	p66	21,24	shc	p66	6464	10714	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Hemodialysis induces p66 -LRB- shc -RRB- gene expression in nondiabetic humans : correlations with oxidative stress and systemic inflammation .
10465268	0	shc	84,87	ret	53,56	shc	ret	6464	5979	Gene	Gene	domain|amod|START_ENTITY specific|nmod|domain END_ENTITY|nmod|specific	The role of amino_acids surrounding tyrosine 1062 in ret in specific binding of the shc phosphotyrosine-binding domain .
15272389	0	shh	73,76	sonic_hedgehog	57,71	shh	sonic hedgehog	30269(Tax:7955)	30269(Tax:7955)	Gene	Gene	expression|appos|START_ENTITY END_ENTITY|dobj|expression	Scale development in fish : a review , with description of sonic_hedgehog _ -LRB- shh -RRB- expression in the zebrafish -LRB- Danio_rerio -RRB- .
17055402	0	short-chain_3-hydroxyacyl-CoA_dehydrogenase	74,117	SCHAD	67,72	short-chain 3-hydroxyacyl-CoA dehydrogenase	SCHAD	3033	3033	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Homicide followed by freezing and burning : usefulness of measuring SCHAD -LRB- short-chain_3-hydroxyacyl-CoA_dehydrogenase -RRB- activity .
12706376	0	short-chain_acyl-CoA_dehydrogenase	14,48	SCAD	50,54	short-chain acyl-CoA dehydrogenase	SCAD	11409(Tax:10090)	11409(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Expression of short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- proteins in the liver of SCAD deficient mice after hydrodynamic gene transfer .
17462936	0	short-chain_acyl-CoA_dehydrogenase	18,52	SCAD	54,58	short-chain acyl-CoA dehydrogenase	SCAD	35	35	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Handling of human short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- variant proteins in transgenic_mice .
9499414	0	short-chain_acyl-CoA_dehydrogenase	44,78	SCAD	80,84	short-chain acyl-CoA dehydrogenase	SCAD	35	35	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of four new mutations in the short-chain_acyl-CoA_dehydrogenase -LRB- SCAD -RRB- gene in two patients : one of the variant alleles , 511C -- > T , is present at an unexpectedly high frequency in the general population , as was the case for 625G -- > A , together conferring susceptibility to ethylmalonic_aciduria .
11574686	0	short_heterodimer_partner	63,88	sterol_12alpha-hydroxylase	15,41	short heterodimer partner	sterol 12alpha-hydroxylase	8431	1582	Gene	Gene	transcription|nmod|START_ENTITY transcription|amod|END_ENTITY	Suppression of sterol_12alpha-hydroxylase transcription by the short_heterodimer_partner : insights into the repression mechanism .
14985507	0	siah-1b	114,121	p53	46,49	siah-1b	p53	20438(Tax:10090)	7157	Gene	Gene	promoter|amod|START_ENTITY element|nmod|promoter identification|nmod|element target|dep|identification target|nmod|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
14985507	0	siah-1b	114,121	p53	84,87	siah-1b	p53	20438(Tax:10090)	7157	Gene	Gene	promoter|amod|START_ENTITY element|nmod|promoter element|amod|functional functional|dep|END_ENTITY	Siah-1b is a direct transcriptional target of p53 : identification of the functional p53 responsive element in the siah-1b promoter .
20087405	0	sialic_acid-binding_immunoglobulin-like_lectin-8	21,69	Siglec-8	71,79	sialic acid-binding immunoglobulin-like lectin-8	Siglec-8	27181	27181	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the sialic_acid-binding_immunoglobulin-like_lectin-8 -LRB- Siglec-8 -RRB- gene are associated with susceptibility to asthma .
10880365	0	sialomucin	62,72	Muc4	85,89	sialomucin	Muc4	295490(Tax:10116)	303887(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Cloning and characterization of the 5 ' flanking region of the sialomucin complex/rat Muc4 gene : promoter activity in cultured cells .
2241892	0	sialophorin	23,34	CD43	36,40	sialophorin	CD43	6693	6693	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the human sialophorin -LRB- CD43 -RRB- gene .
8157205	0	sialophorin	20,31	CD43	33,37	sialophorin	CD43	6693	6693	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of human sialophorin -LRB- CD43 -RRB- in a human x mouse somatic cell hybrid .
16229822	0	sialyltransferase_8B	64,84	SIAT8B	86,92	sialyltransferase 8B	SIAT8B	8128	8128	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between polymorphisms in the promoter region of the sialyltransferase_8B -LRB- SIAT8B -RRB- gene and schizophrenia .
12039050	0	sideroflexin_5	10,24	SFXN5	26,31	sideroflexin 5	SFXN5	94097	94097	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human sideroflexin_5 -LRB- SFXN5 -RRB- gene : sequence , expression analysis and exclusion as a candidate for PARK3 .
25151382	0	siglec-4a	40,49	myelin-associated_glycoprotein	8,38	siglec-4a	myelin-associated glycoprotein	17136(Tax:10090)	17136(Tax:10090)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of myelin-associated_glycoprotein -LRB- siglec-4a -RRB- in the nervous system .
21314692	0	sigma-1_receptor	81,97	CA1	124,127	sigma-1 receptor	CA1	29336(Tax:10116)	310218(Tax:10116)	Gene	Gene	activation|amod|START_ENTITY activation|nmod|neurons neurons|compound|END_ENTITY	Ethanol exposure in early adolescence inhibits intrinsic neuronal plasticity via sigma-1_receptor activation in hippocampal CA1 neurons .
16879472	0	sigma-1_receptor	21,37	c-Fos	71,76	sigma-1 receptor	c-Fos	18391(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Propofol acts at the sigma-1_receptor and inhibits pentazocine-induced c-Fos expression in the mouse posterior cingulate and retrosplenial cortices .
26792723	0	sigma_1_receptor	122,138	Tumor_necrosis_factor-related_apoptosis-inducing_ligand	0,55	sigma 1 receptor	Tumor necrosis factor-related apoptosis-inducing ligand	10280	8743	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- activates caspases in human prostate_cancer cells through sigma_1_receptor .
12446684	0	signal-regulatory_protein-alpha	26,57	SHPS-1	70,76	signal-regulatory protein-alpha	SHPS-1	19261(Tax:10090)	19261(Tax:10090)	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	Dominant negative form of signal-regulatory_protein-alpha -LRB- SIRPalpha / SHPS-1 -RRB- inhibits tumor_necrosis_factor-mediated apoptosis by activation of NF-kappa_B .
10921027	0	signal-regulatory_protein_alpha	15,46	SIRP_alpha	48,58	signal-regulatory protein alpha	SIRP alpha	140885	140885	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of signal-regulatory_protein_alpha -LRB- SIRP_alpha -RRB- in hepatocellular_carcinoma -RSB- .
11298125	0	signal-transducer_and_activator_of_transcription_1	14,64	STAT1	66,71	signal-transducer and activator of transcription 1	STAT1	6772	6772	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of signal-transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- in pouchitis .
17403676	0	signal-transducing_adaptor_molecule	20,55	Rin1	0,4	signal-transducing adaptor molecule	Rin1	8027	9610	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Rin1 interacts with signal-transducing_adaptor_molecule -LRB- STAM -RRB- and mediates epidermal_growth_factor_receptor trafficking and degradation .
25541225	0	signal_peptide-Cub-Egf_domain-containing_protein-1	27,77	SCUBE-1	79,86	signal peptide-Cub-Egf domain-containing protein-1	SCUBE-1	80274	80274	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Diagnostic value of plasma signal_peptide-Cub-Egf_domain-containing_protein-1 -LRB- SCUBE-1 -RRB- in an experimental model of acute ischemic_stroke .
12972007	0	signal_peptide_peptidase	34,58	SPP	60,63	signal peptide peptidase	SPP	14950(Tax:10090)	14950(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the presenilin-like signal_peptide_peptidase -LRB- SPP -RRB- in mouse adult brain and during development .
24768597	0	signal_peptide_peptidase	14,38	SPP	40,43	signal peptide peptidase	SPP	81502	81502	Gene	Gene	Inhibitors|nmod|START_ENTITY Inhibitors|appos|END_ENTITY	Inhibitors of signal_peptide_peptidase -LRB- SPP -RRB- affect HSV-1 infectivity in vitro and in vivo .
23132852	0	signal_peptide_peptidase-like_3	48,79	envelope_protein	12,28	signal peptide peptidase-like 3	envelope protein	121665	64006	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Foamy virus envelope_protein is a substrate for signal_peptide_peptidase-like_3 -LRB- SPPL3 -RRB- .
14764731	0	signal_regulatory_protein_alpha	92,123	CD47	69,73	signal regulatory protein alpha	CD47	140885	961	Gene	Gene	blocking|nmod|START_ENTITY blocking|dobj|interactions interactions|nummod|END_ENTITY	Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal_regulatory_protein_alpha .
17098740	0	signal_regulatory_protein_alpha	56,87	CD47	27,31	signal regulatory protein alpha	CD47	140885	961	Gene	Gene	interactions|nmod|START_ENTITY interactions|nummod|END_ENTITY	Phylogenetic divergence of CD47 interactions with human signal_regulatory_protein_alpha reveals locus of species specificity .
20826801	0	signal_regulatory_protein_alpha	32,63	CD47	90,94	signal regulatory protein alpha	CD47	140885	961	Gene	Gene	dimerization|nmod|START_ENTITY role|nmod|dimerization role|nmod|END_ENTITY	The role of cis dimerization of signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- in binding to CD47 .
17369261	0	signal_regulatory_protein_alpha	32,63	SIRPalpha	65,74	signal regulatory protein alpha	SIRPalpha	140885	140885	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The structure of the macrophage signal_regulatory_protein_alpha -LRB- SIRPalpha -RRB- inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors .
11382751	0	signal_tranducer_and_activator_of_transcription_3	136,185	extracellular_signal-regulated_kinase	15,52	signal tranducer and activator of transcription 3	extracellular signal-regulated kinase	6774	5594	Gene	Gene	activation|amod|START_ENTITY kinases|nmod|activation kinases|nsubj|role role|nmod|protein protein|amod|END_ENTITY	A role for the extracellular_signal-regulated_kinase and p38 mitogen-activated protein kinases in interleukin-1_beta-stimulated delayed signal_tranducer_and_activator_of_transcription_3 activation , atrial_natriuretic_factor expression , and cardiac myocyte morphology .
9461509	0	signal_transducer_and_activator_of_transcription-3	46,96	STAT-3	98,104	signal transducer and activator of transcription-3	STAT-3	6774	6774	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	The nuclear factor interleukin-6 -LRB- NF-IL6 -RRB- and signal_transducer_and_activator_of_transcription-3 -LRB- STAT-3 -RRB- signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat_shock .
18413761	0	signal_transducer_and_activator_of_transcription-3	78,128	STAT3	130,135	signal transducer and activator of transcription-3	STAT3	6774	6774	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Triterpenoid_CDDO-methyl_ester inhibits the Janus-activated kinase-1 -LRB- JAK1 -RRB- -- > signal_transducer_and_activator_of_transcription-3 -LRB- STAT3 -RRB- pathway by direct inhibition of JAK1 and STAT3 .
7488223	0	signal_transducer_and_activator_of_transcription-3	14,64	Stat3	66,71	signal transducer and activator of transcription-3	Stat3	6774	6774	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- expression by interferon-gamma and interleukin-6 in hepatoma cells .
7488223	0	signal_transducer_and_activator_of_transcription-3	14,64	interferon-gamma	87,103	signal transducer and activator of transcription-3	interferon-gamma	6774	3458	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription-3 -LRB- Stat3 -RRB- expression by interferon-gamma and interleukin-6 in hepatoma cells .
14984365	0	signal_transducer_and_activator_of_transcription_1	69,119	STAT1	62,67	signal transducer and activator of transcription 1	STAT1	25124(Tax:10116)	25124(Tax:10116)	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Hypoxia/re-oxygenation-induced , redox-dependent activation of STAT1 -LRB- signal_transducer_and_activator_of_transcription_1 -RRB- confers resistance to apoptotic cell death via hsp70 induction .
17033032	0	signal_transducer_and_activator_of_transcription_1	15,65	STAT1	67,72	signal transducer and activator of transcription 1	STAT1	510814(Tax:9913)	510814(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of the signal_transducer_and_activator_of_transcription_1 -LRB- STAT1 -RRB- gene on milk production traits in Holstein dairy cattle .
15096606	0	signal_transducer_and_activator_of_transcription_3	41,91	Cyclin-dependent_kinase_5	0,25	signal transducer and activator of transcription 3	Cyclin-dependent kinase 5	20848(Tax:10090)	12568(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	Cyclin-dependent_kinase_5 phosphorylates signal_transducer_and_activator_of_transcription_3 and regulates its transcriptional activity .
16510571	0	signal_transducer_and_activator_of_transcription_3	89,139	Cyclin_D1	0,9	signal transducer and activator of transcription 3	Cyclin D1	6774	595	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Cyclin_D1 is transcriptionally regulated by and required for transformation by activated signal_transducer_and_activator_of_transcription_3 .
17909010	0	signal_transducer_and_activator_of_transcription_3	49,99	Epidermal_growth_factor_receptor	0,32	signal transducer and activator of transcription 3	Epidermal growth factor receptor	6774	1956	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Epidermal_growth_factor_receptor cooperates with signal_transducer_and_activator_of_transcription_3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression .
12867595	0	signal_transducer_and_activator_of_transcription_3	52,102	GRIM-19	25,32	signal transducer and activator of transcription 3	GRIM-19	6774	51079	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	The cell death regulator GRIM-19 is an inhibitor of signal_transducer_and_activator_of_transcription_3 .
16840717	0	signal_transducer_and_activator_of_transcription_3	58,108	Interleukin-6	0,13	signal transducer and activator of transcription 3	Interleukin-6	6774	3569	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|induction induction|amod|END_ENTITY	Interleukin-6 induction of protein s is regulated through signal_transducer_and_activator_of_transcription_3 .
24168060	0	signal_transducer_and_activator_of_transcription_3	119,169	Interleukin-6	0,13	signal transducer and activator of transcription 3	Interleukin-6	25125(Tax:10116)	24498(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY stem|nmod|signaling induces|ccomp|stem induces|nsubj|END_ENTITY	Interleukin-6 induces malignant transformation of rat mesenchymal stem cells in association with enhanced signaling of signal_transducer_and_activator_of_transcription_3 .
17082312	0	signal_transducer_and_activator_of_transcription_3	64,114	Leptin	0,6	signal transducer and activator of transcription 3	Leptin	25125(Tax:10116)	25608(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY responses|compound|signaling uncoupling|nmod|responses reveals|dobj|uncoupling reveals|nsubj|antagonist antagonist|compound|END_ENTITY	Leptin antagonist reveals an uncoupling between leptin receptor signal_transducer_and_activator_of_transcription_3 signaling and metabolic responses with central leptin resistance .
23622344	0	signal_transducer_and_activator_of_transcription_3	62,112	Leptin	0,6	signal transducer and activator of transcription 3	Leptin	6774	3952	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Leptin stimulates interleukin-6 production via janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 in rheumatoid synovial fibroblasts .
22396544	0	signal_transducer_and_activator_of_transcription_3	95,145	Leukotriene_B4_receptor-2	0,25	signal transducer and activator of transcription 3	Leukotriene B4 receptor-2	6774	56413	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Leukotriene_B4_receptor-2 promotes invasiveness and metastasis of ovarian_cancer cells through signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- - dependent up-regulation of matrix_metalloproteinase_2 .
18356286	0	signal_transducer_and_activator_of_transcription_3	43,93	Nescient_helix-loop-helix_2	0,27	signal transducer and activator of transcription 3	Nescient helix-loop-helix 2	20848(Tax:10090)	18072(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nescient_helix-loop-helix_2 interacts with signal_transducer_and_activator_of_transcription_3 to regulate transcription of prohormone_convertase_1 / 3 .
21399864	0	signal_transducer_and_activator_of_transcription_3	68,118	Oncostatin_M	0,12	signal transducer and activator of transcription 3	Oncostatin M	6774	5008	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Oncostatin_M promotes proliferation of ovarian_cancer cells through signal_transducer_and_activator_of_transcription_3 .
12894500	0	signal_transducer_and_activator_of_transcription_3	12,62	STAT3	64,69	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in gastrointestinal_stromal_tumors .
16705451	0	signal_transducer_and_activator_of_transcription_3	8,58	STAT3	60,65	signal transducer and activator of transcription 3	STAT3	20848(Tax:10090)	20848(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in stretch_injury to bladder smooth muscle cells .
19223541	0	signal_transducer_and_activator_of_transcription_3	36,86	STAT3	88,93	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Sustained Src inhibition results in signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding .
20149460	0	signal_transducer_and_activator_of_transcription_3	24,74	STAT3	76,81	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel mutation in the signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- gene , in hyper-IgE_syndrome .
20693278	0	signal_transducer_and_activator_of_transcription_3	53,103	STAT3	105,110	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Microtubule-targeted chemotherapeutic agents inhibit signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- signaling .
21107604	0	signal_transducer_and_activator_of_transcription_3	105,155	STAT3	157,162	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Destructive pulmonary_staphylococcal_infection in a boy with hyper-IgE_syndrome : a novel mutation in the signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- gene -LRB- p.Y657S -RRB- .
22179221	0	signal_transducer_and_activator_of_transcription_3	98,148	STAT3	150,155	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	The peroxisome_proliferator-activated_receptor -LRB- PPAR -RRB- b / agonist GW501516 inhibits IL-6-induced signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation and insulin resistance in human liver cells .
24124070	0	signal_transducer_and_activator_of_transcription_3	29,79	STAT3	81,86	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|appos|END_ENTITY	Effective down-regulation of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast_tumor cells to conventional chemotherapy .
24167124	0	signal_transducer_and_activator_of_transcription_3	29,79	STAT3	81,86	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	down-regulation|nmod|START_ENTITY down-regulation|appos|END_ENTITY	Effective down-regulation of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast_tumor cells to conventional chemotherapy .
24658061	0	signal_transducer_and_activator_of_transcription_3	43,93	STAT3	95,100	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Raf_kinase_inhibitor_protein -LRB- RKIP -RRB- blocks signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in breast_and_prostate_cancer .
25555814	0	signal_transducer_and_activator_of_transcription_3	20,70	STAT3	72,77	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of fish signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- in nodavirus_infection_induced_cell_death .
26500281	0	signal_transducer_and_activator_of_transcription_3	85,135	STAT3	137,142	signal transducer and activator of transcription 3	STAT3	6774	6774	Gene	Gene	signalling|amod|START_ENTITY signalling|appos|END_ENTITY	Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- signalling in HER2-overexpressing BT-474 breast_cancer cells .
19571399	0	signal_transducer_and_activator_of_transcription_3	98,148	Silencing_mediator_of_retinoic_acid_and_thyroid_hormone_receptor	0,64	signal transducer and activator of transcription 3	Silencing mediator of retinoic acid and thyroid hormone receptor	6774	9612	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Silencing_mediator_of_retinoic_acid_and_thyroid_hormone_receptor regulates enhanced activation of signal_transducer_and_activator_of_transcription_3 by epstein-barr_virus-derived epstein-barr nuclear antigen 2 .
21486047	0	signal_transducer_and_activator_of_transcription_3	100,150	Src	69,72	signal transducer and activator of transcription 3	Src	6774	6714	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 -LRB- SH2 -RRB- domain of signal_transducer_and_activator_of_transcription_3 .
20063378	0	signal_transducer_and_activator_of_transcription_3	14,64	Stat3	66,71	signal transducer and activator of transcription 3	Stat3	6774	6774	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Activation of signal_transducer_and_activator_of_transcription_3 -LRB- Stat3 -RRB- pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis .
12707028	0	signal_transducer_and_activator_of_transcription_3	12,62	Stat_3	64,70	signal transducer and activator of transcription 3	Stat 3	6774	6774	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Analysis of signal_transducer_and_activator_of_transcription_3 -LRB- Stat_3 -RRB- pathway in multiple_myeloma : Stat_3 activation and cyclin_D1 dysregulation are mutually exclusive events .
17683382	0	signal_transducer_and_activator_of_transcription_3	58,108	Suppressor_of_cytokine_signaling_3	0,34	signal transducer and activator of transcription 3	Suppressor of cytokine signaling 3	6774	9021	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Suppressor_of_cytokine_signaling_3 negative regulation of signal_transducer_and_activator_of_transcription_3 in platelet-derived growth factor-induced fibroblast migration .
19258507	0	signal_transducer_and_activator_of_transcription_3	35,85	Toll-like_receptor_9	0,20	signal transducer and activator of transcription 3	Toll-like receptor 9	20848(Tax:10090)	81897(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Toll-like_receptor_9 activation of signal_transducer_and_activator_of_transcription_3 constrains its agonist-based immunotherapy .
12873986	0	signal_transducer_and_activator_of_transcription_3	39,89	epidermal_growth_factor_receptor	119,151	signal transducer and activator of transcription 3	epidermal growth factor receptor	6774	1956	Gene	Gene	sites|amod|START_ENTITY Identification|nmod|sites Identification|nmod|END_ENTITY	Identification and characterization of signal_transducer_and_activator_of_transcription_3 recruitment sites within the epidermal_growth_factor_receptor .
16278387	0	signal_transducer_and_activator_of_transcription_3	41,91	interleukin-6	95,108	signal transducer and activator of transcription 3	interleukin-6	6774	3569	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|lung_cancer lung_cancer|amod|END_ENTITY	Cyclooxygenase-2-dependent activation of signal_transducer_and_activator_of_transcription_3 by interleukin-6 in non-small cell lung_cancer .
17935227	0	signal_transducer_and_activator_of_transcription_3	118,168	interleukin-6	104,117	signal transducer and activator of transcription 3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Gut-derived commensal bacterial products inhibit liver dendritic cell maturation by stimulating hepatic interleukin-6 / signal_transducer_and_activator_of_transcription_3 activity .
19147545	0	signal_transducer_and_activator_of_transcription_3	66,116	interleukin-6	40,53	signal transducer and activator of transcription 3	interleukin-6	6774	3569	Gene	Gene	activate|dobj|START_ENTITY END_ENTITY|xcomp|activate	The Fer tyrosine kinase cooperates with interleukin-6 to activate signal_transducer_and_activator_of_transcription_3 and promote human prostate_cancer cell growth .
21940958	0	signal_transducer_and_activator_of_transcription_3	48,98	interleukin-6	19,32	signal transducer and activator of transcription 3	interleukin-6	20848(Tax:10090)	16193(Tax:10090)	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|Neuroprotection Neuroprotection|nmod|END_ENTITY	Neuroprotection by interleukin-6 is mediated by signal_transducer_and_activator_of_transcription_3 and antioxidative signaling in ischemic_stroke .
23622344	0	signal_transducer_and_activator_of_transcription_3	62,112	interleukin-6	18,31	signal transducer and activator of transcription 3	interleukin-6	6774	3569	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Leptin stimulates interleukin-6 production via janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 in rheumatoid synovial fibroblasts .
20921429	0	signal_transducer_and_activator_of_transcription_3	111,161	janus_kinase_2	96,110	signal transducer and activator of transcription 3	janus kinase 2	20848(Tax:10090)	16452(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Interleukin_6 knockout prevents angiotensin_II hypertension : role of renal vasoconstriction and janus_kinase_2 / signal_transducer_and_activator_of_transcription_3 activation .
14764629	0	signal_transducer_and_activator_of_transcription_3	8,58	leptin	112,118	signal transducer and activator of transcription 3	leptin	25125(Tax:10116)	25608(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_3 in regulation of hypothalamic trh gene expression by leptin .
17082312	0	signal_transducer_and_activator_of_transcription_3	64,114	leptin	162,168	signal transducer and activator of transcription 3	leptin	25125(Tax:10116)	25608(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY responses|compound|signaling uncoupling|nmod|responses reveals|dobj|uncoupling reveals|nmod|resistance resistance|compound|END_ENTITY	Leptin antagonist reveals an uncoupling between leptin receptor signal_transducer_and_activator_of_transcription_3 signaling and metabolic responses with central leptin resistance .
17082312	0	signal_transducer_and_activator_of_transcription_3	64,114	leptin	48,54	signal transducer and activator of transcription 3	leptin	25125(Tax:10116)	25608(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Leptin antagonist reveals an uncoupling between leptin receptor signal_transducer_and_activator_of_transcription_3 signaling and metabolic responses with central leptin resistance .
18096691	0	signal_transducer_and_activator_of_transcription_3	33,83	leptin	87,93	signal transducer and activator of transcription 3	leptin	20848(Tax:10090)	16846(Tax:10090)	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|neurons neurons|amod|END_ENTITY	Specific physiological roles for signal_transducer_and_activator_of_transcription_3 in leptin receptor-expressing neurons .
21163886	0	signal_transducer_and_activator_of_transcription_3	117,167	leptin	52,58	signal transducer and activator of transcription 3	leptin	6774	3952	Gene	Gene	activation|nmod|START_ENTITY suppressing|dobj|activation inhibits|advcl|suppressing inhibits|dobj|actions actions|nmod|END_ENTITY	Benzyl_isothiocyanate inhibits oncogenic actions of leptin in human breast_cancer cells by suppressing activation of signal_transducer_and_activator_of_transcription_3 .
12697721	0	signal_transducer_and_activator_of_transcription_3	8,58	proopiomelanocortin	89,108	signal transducer and activator of transcription 3	proopiomelanocortin	25125(Tax:10116)	24664(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin .
18436865	0	signal_transducer_and_activator_of_transcription_5	18,68	CD34	80,84	signal transducer and activator of transcription 5	CD34	6776	947	Gene	Gene	START_ENTITY|nmod|cells cells|nummod|+ +|compound|END_ENTITY	Downregulation of signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- in CD34 + cells promotes megakaryocytic development , whereas activation of STAT5 drives erythropoiesis .
15976008	0	signal_transducer_and_activator_of_transcription_5	69,119	EGF	139,142	signal transducer and activator of transcription 5	EGF	6776	1950	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|cells cells|compound|END_ENTITY	Estrogen negatively regulates epidermal growth factor -LRB- EGF -RRB- - mediated signal_transducer_and_activator_of_transcription_5 signaling in human EGF family receptor-overexpressing breast_cancer cells .
15976008	0	signal_transducer_and_activator_of_transcription_5	69,119	EGF	55,58	signal transducer and activator of transcription 5	EGF	6776	1950	Gene	Gene	factor|dep|START_ENTITY factor|appos|END_ENTITY	Estrogen negatively regulates epidermal growth factor -LRB- EGF -RRB- - mediated signal_transducer_and_activator_of_transcription_5 signaling in human EGF family receptor-overexpressing breast_cancer cells .
15016718	0	signal_transducer_and_activator_of_transcription_5	59,109	Janus_tyrosine_kinase_2	35,58	signal transducer and activator of transcription 5	Janus tyrosine kinase 2	20850(Tax:10090)	16452(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY Suppression|parataxis|signaling Suppression|nmod|END_ENTITY	Suppression of growth_hormone -LRB- GH -RRB- Janus_tyrosine_kinase_2 / signal_transducer_and_activator_of_transcription_5 signaling pathway in transgenic_mice overexpressing bovine GH .
11435608	0	signal_transducer_and_activator_of_transcription_5	109,159	STAT5	102,107	signal transducer and activator of transcription 5	STAT5	6776	6776	Gene	Gene	mechanism|appos|START_ENTITY mechanism|nmod|END_ENTITY	Interleukin-2 inhibits glucocorticoid_receptor transcriptional activity through a mechanism involving STAT5 -LRB- signal_transducer_and_activator_of_transcription_5 -RRB- but not AP-1 .
24753251	0	signal_transducer_and_activator_of_transcription_5	86,136	STAT5	138,143	signal transducer and activator of transcription 5	STAT5	6776	6776	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Regulation of the interferon_regulatory_factor-8 -LRB- IRF-8 -RRB- tumor suppressor gene by the signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- transcription factor in chronic_myeloid_leukemia .
25087955	0	signal_transducer_and_activator_of_transcription_5	63,113	STAT5	115,120	signal transducer and activator of transcription 5	STAT5	6776	6776	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Serotonin suppresses b-casein expression via inhibition of the signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- protein phosphorylation in human mammary epithelial cells MCF-12A .
9774439	0	signal_transducer_and_activator_of_transcription_5	49,99	STAT5	101,106	signal transducer and activator of transcription 5	STAT5	6776	6776	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Proteasomes regulate erythropoietin_receptor and signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- activation .
18586824	0	signal_transducer_and_activator_of_transcription_5	63,113	epidermal_growth_factor_receptor	8,40	signal transducer and activator of transcription 5	epidermal growth factor receptor	6776	1956	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Nuclear epidermal_growth_factor_receptor -LRB- EGFR -RRB- interacts with signal_transducer_and_activator_of_transcription_5 -LRB- STAT5 -RRB- in activating Aurora-A gene expression .
19047094	0	signal_transducer_and_activator_of_transcription_5	27,77	epidermal_growth_factor_receptor	160,192	signal transducer and activator of transcription 5	epidermal growth factor receptor	6776	1956	Gene	Gene	activation|nmod|START_ENTITY contributes|nsubj|activation contributes|xcomp|END_ENTITY	Constitutive activation of signal_transducer_and_activator_of_transcription_5 contributes to tumor growth , epithelial-mesenchymal transition , and resistance to epidermal_growth_factor_receptor targeting .
11522649	0	signal_transducer_and_activator_of_transcription_5	8,58	nucleophosmin	62,75	signal transducer and activator of transcription 5	nucleophosmin	20850(Tax:10090)	18148(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of signal_transducer_and_activator_of_transcription_5 in nucleophosmin / anaplastic_lymphoma_kinase-mediated malignant transformation of lymphoid cells .
16457814	0	signal_transducer_and_activator_of_transcription_5A	73,124	Peroxisome_proliferator-activated_receptor_gamma	0,48	signal transducer and activator of transcription 5A	Peroxisome proliferator-activated receptor gamma	20850(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma regulates expression of signal_transducer_and_activator_of_transcription_5A .
16882096	0	signal_transducer_and_activator_of_transcription_5B	57,108	STAT5B	115,121	signal transducer and activator of transcription 5B	STAT5B	20851(Tax:10090)	20851(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism and chromosomal localization of the porcine signal_transducer_and_activator_of_transcription_5B gene -LRB- STAT5B -RRB- .
16123156	0	signal_transducer_and_activator_of_transcription_5b	33,84	Prolactin	0,9	signal transducer and activator of transcription 5b	Prolactin	25126(Tax:10116)	24683(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Prolactin specifically activates signal_transducer_and_activator_of_transcription_5b in neuroendocrine dopaminergic neurons .
19630967	0	signal_transducer_and_activator_of_transcription_5b	17,68	STAT5b	70,76	signal transducer and activator of transcription 5b	STAT5b	6777	6777	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for signal_transducer_and_activator_of_transcription_5b -LRB- STAT5b -RRB- in beta1-integrin-mediated human breast_cancer cell migration .
11682625	0	signal_transducer_and_activator_of_transcription_5b	79,130	Stat5b	132,138	signal transducer and activator of transcription 5b	Stat5b	25126(Tax:10116)	25126(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	PRL-induced ERalpha gene expression is mediated by Janus_kinase_2 -LRB- Jak2 -RRB- while signal_transducer_and_activator_of_transcription_5b -LRB- Stat5b -RRB- phosphorylation involves Jak2 and a second tyrosine kinase .
26915678	0	signal_transducer_and_activator_of_transcription_6	53,103	STAT-6	105,111	signal transducer and activator of transcription 6	STAT-6	6778	6778	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Nonsteroidal anti-inflammatory-induced inhibition of signal_transducer_and_activator_of_transcription_6 -LRB- STAT-6 -RRB- phosphorylation in aspirin-exacerbated respiratory_disease .
21762972	0	signal_transducer_and_activator_of_transcription_6	4,54	STAT6	61,66	signal transducer and activator of transcription 6	STAT6	20852(Tax:10090)	6778	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The signal_transducer_and_activator_of_transcription_6 gene -LRB- STAT6 -RRB- increases the propensity of patients with atopic dermatitis toward disseminated viral skin_infections .
24107646	0	signal_transducer_and_activator_of_transcription_6	32,82	interleukin-4	18,31	signal transducer and activator of transcription 6	interleukin-4	6778	3565	Gene	Gene	signaling|nsubj|START_ENTITY Activation|parataxis|signaling Activation|nmod|END_ENTITY	Activation of the interleukin-4 / signal_transducer_and_activator_of_transcription_6 signaling pathway and homeodomain-interacting_protein_kinase_2 production by tonsillar mononuclear cells in IgA_nephropathy .
11104703	0	signal_transducer_and_activator_of_transcription_factor_1	123,180	IL-1beta	38,46	signal transducer and activator of transcription factor 1	IL-1beta	6772	3553	Gene	Gene	inhibits|dobj|START_ENTITY signalling|parataxis|inhibits signalling|nsubj|Cross-talk Cross-talk|nmod|END_ENTITY	Cross-talk between interleukin_1beta -LRB- IL-1beta -RRB- and IL-6 signalling pathways : IL-1beta selectively inhibits IL-6-activated signal_transducer_and_activator_of_transcription_factor_1 -LRB- STAT1 -RRB- by a proteasome-dependent mechanism .
11104703	0	signal_transducer_and_activator_of_transcription_factor_1	123,180	IL-1beta	78,86	signal transducer and activator of transcription factor 1	IL-1beta	6772	3553	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Cross-talk between interleukin_1beta -LRB- IL-1beta -RRB- and IL-6 signalling pathways : IL-1beta selectively inhibits IL-6-activated signal_transducer_and_activator_of_transcription_factor_1 -LRB- STAT1 -RRB- by a proteasome-dependent mechanism .
24451065	0	signal_transducers_and_activators_of_transcription_1	9,61	C-C_motif_chemokine_ligand_2	88,116	signal transducers and activators of transcription 1	C-C motif chemokine ligand 2	6772	6347	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Elevated signal_transducers_and_activators_of_transcription_1 correlates with increased C-C_motif_chemokine_ligand_2 and C-X-C_motif_chemokine_10 levels in peripheral blood of patients with systemic_lupus_erythematosus .
17699108	0	signal_transducers_and_activators_of_transcription_3	10,62	CD46	81,85	signal transducers and activators of transcription 3	CD46	6774	4179	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Activated signal_transducers_and_activators_of_transcription_3 signaling induces CD46 expression and protects human cancer cells from complement-dependent cytotoxicity .
21586572	0	signal_transducers_and_activators_of_transcription_3	147,199	MK2	107,110	signal transducers and activators of transcription 3	MK2	6774	9261	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	Distinct functions of the mitogen-activated protein kinase-activated protein -LRB- MAPKAP -RRB- kinases MK2 and MK3 : MK2 mediates lipopolysaccharide-induced signal_transducers_and_activators_of_transcription_3 -LRB- STAT3 -RRB- activation by preventing negative regulatory effects of MK3 .
21577321	0	signal_transducers_and_activators_of_transcription_3	20,72	STAT3	74,79	signal transducers and activators of transcription 3	STAT3	6774	6774	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Upregulation of the signal_transducers_and_activators_of_transcription_3 -LRB- STAT3 -RRB- pathway in lymphatic metastases of papillary thyroid_cancer .
23166328	0	signal_transducers_and_activators_of_transcription_3	60,112	STAT3	114,119	signal transducers and activators of transcription 3	STAT3	6774	6774	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Cytokine response is determined by duration of receptor and signal_transducers_and_activators_of_transcription_3 -LRB- STAT3 -RRB- activation .
10479532	0	signaling_lymphocytic_activation_molecule	8,49	SLAM	51,55	signaling lymphocytic activation molecule	SLAM	6504	6504	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Altered signaling_lymphocytic_activation_molecule -LRB- SLAM -RRB- expression in HIV_infection and redirection of HIV-specific responses via SLAM triggering .
19155483	0	signaling_lymphocytic_activation_molecule-associated_protein	21,81	IFN-gamma	98,107	signaling lymphocytic activation molecule-associated protein	IFN-gamma	20400(Tax:10090)	15978(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|production production|amod|END_ENTITY	The adaptor molecule signaling_lymphocytic_activation_molecule-associated_protein -LRB- SAP -RRB- regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression .
11435691	0	silencing_mediator_of_retinoid_and_thyroid_hormone_receptor	85,144	SMRT	146,150	silencing mediator of retinoid and thyroid hormone receptor	SMRT	9612	9612	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization and refined mapping of the human nuclear_corepressor_2 -LRB- NCOR2 -RRB- / silencing_mediator_of_retinoid_and_thyroid_hormone_receptor -LRB- SMRT -RRB- gene on chromosome 12q24 .3 .
16373395	0	silencing_mediator_of_retinoid_and_thyroid_hormone_receptor	17,76	androgen_receptor	177,194	silencing mediator of retinoid and thyroid hormone receptor	androgen receptor	9612	367	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	The corepressors silencing_mediator_of_retinoid_and_thyroid_hormone_receptor and nuclear receptor corepressor are involved in agonist - and antagonist-regulated transcription by androgen_receptor .
19940103	0	silent_mating_type_information_regulation-1	54,97	nuclear_transcription_factor-kappaB	117,152	silent mating type information regulation-1	nuclear transcription factor-kappaB	93759(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Resveratrol -LRB- trans-3 ,5,4 ' - trihydroxystilbene -RRB- induces silent_mating_type_information_regulation-1 and down-regulates nuclear_transcription_factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis .
7982564	0	sin_1	0,5	mod_1	76,81	sin 1	mod 1	839574(Tax:3702)	815152(Tax:3702)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	sin_1 , a mutation affecting female fertility in Arabidopsis , interacts with mod_1 , its recessive modifier .
7895278	0	sina	59,63	Siah-2	14,20	sina	Siah-2	39884(Tax:7227)	20439(Tax:10090)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Expression of Siah-2 , a vertebrate homologue of Drosophila sina , in germ cells of the mouse ovary and testis .
8661114	0	single-minded	14,27	SIM	29,32	single-minded	SIM	6493	6493	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The mammalian single-minded -LRB- SIM -RRB- gene : mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome .
1533042	0	single-minded	77,90	snail	56,61	single-minded	snail	41612(Tax:7227)	34908(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY protein|nmod|gene protein|compound|END_ENTITY	Dorsal-ventral patterning in Drosophila : DNA binding of snail protein to the single-minded gene .
11091086	0	single-minded	128,141	xSim	49,53	single-minded	xSim	41612(Tax:7227)	373634(Tax:8355)	Gene	Gene	related|nmod|START_ENTITY related|nsubj|expression expression|nmod|END_ENTITY	Characterization and developmental expression of xSim , a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded .
10915774	0	single-minded_2	61,76	Sim2	83,87	single-minded 2	Sim2	20465(Tax:10090)	20465(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mice trisomic for a bacterial artificial chromosome with the single-minded_2 gene -LRB- Sim2 -RRB- show phenotypes similar to some of those present in the partial_trisomy_16 mouse models of Down_syndrome .
1375330	0	single-stranded_DNA-binding_protein	10,45	DNA_polymerase_alpha	89,109	single-stranded DNA-binding protein	DNA polymerase alpha	6117	5422	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|END_ENTITY	HeLa cell single-stranded_DNA-binding_protein increases the accuracy of DNA synthesis by DNA_polymerase_alpha in vitro .
11854290	0	single-stranded_DNA-binding_protein	89,124	SSB	126,129	single-stranded DNA-binding protein	SSB	20466802	20466802	Gene	Gene	START_ENTITY|appos|protein protein|compound|END_ENTITY	Complete inhibition of Streptococcus_pneumoniae RecA protein-catalyzed ATP hydrolysis by single-stranded_DNA-binding_protein -LRB- SSB protein -RRB- : implications for the mechanism of SSB protein-stimulated DNA strand exchange .
24821721	0	single_immunoglobulin_interleukin-1_receptor-related_molecule	29,90	SIGIRR	92,98	single immunoglobulin interleukin-1 receptor-related molecule	SIGIRR	59307	59307	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
24821721	0	single_immunoglobulin_interleukin-1_receptor-related_molecule	29,90	specificity_protein_1	126,147	single immunoglobulin interleukin-1 receptor-related molecule	specificity protein 1	59307	6667	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
9488676	0	single_strand_DNA_binding_protein	44,77	MucB	24,28	single strand DNA binding protein	MucB	11027484	3861227(Tax:562)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The mutagenesis protein MucB interacts with single_strand_DNA_binding_protein and induces a major conformational change in its complex with single-stranded DNA .
26627546	0	sirtuin-1	10,19	IL-4	30,34	sirtuin-1	IL-4	23411	3565	Gene	Gene	increases|amod|START_ENTITY END_ENTITY|nsubj|increases	Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma .
25356114	0	sirtuin_1	69,78	Interleukin_6	0,13	sirtuin 1	Interleukin 6	309757(Tax:10116)	24498(Tax:10116)	Gene	Gene	increases|nmod|START_ENTITY increases|nsubj|END_ENTITY	Interleukin_6 increases dysfunction of organs in sepsis rats through sirtuin_1 .
20506278	0	sirtuin_1	39,48	Nicotinamide_phosphoribosyltransferase	0,38	sirtuin 1	Nicotinamide phosphoribosyltransferase	23411	10135	Gene	Gene	involved|nsubjpass|START_ENTITY END_ENTITY|parataxis|involved	Nicotinamide_phosphoribosyltransferase / sirtuin_1 pathway is involved in human_immunodeficiency_virus_type_1 Tat-mediated long terminal repeat transactivation .
22640422	0	sirtuin_1	25,34	SIRT1	36,41	sirtuin 1	SIRT1	309757(Tax:10116)	309757(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Metabolic programming of sirtuin_1 -LRB- SIRT1 -RRB- expression by moderate energy restriction during gestation in rats may be related to obesity susceptibility in later life .
24145124	0	sirtuin_1	18,27	SIRT1	29,34	sirtuin 1	SIRT1	23411	23411	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of mammalian sirtuin_1 -LRB- SIRT1 -RRB- in lipids metabolism and cell proliferation of goose primary hepatocytes .
24395567	0	sirtuin_1	21,30	SIRT1	32,37	sirtuin 1	SIRT1	309757(Tax:10116)	309757(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Resveratrol restores sirtuin_1 -LRB- SIRT1 -RRB- activity and pyruvate_dehydrogenase_kinase_1 -LRB- PDK1 -RRB- expression after hemorrhagic_injury in a rat model .
26105582	0	sirtuin_1	96,105	fetuin_A	106,114	sirtuin 1	fetuin A	23411	197	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Fenofibrate reduces inflammation in obese patients with or without type_2_diabetes_mellitus via sirtuin_1 / fetuin_A axis .
26105582	0	sirtuin_1	96,105	fetuin_A	106,114	sirtuin 1	fetuin A	23411	197	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Fenofibrate reduces inflammation in obese patients with or without type_2_diabetes_mellitus via sirtuin_1 / fetuin_A axis .
19498162	0	sirtuin_1	93,102	hypoxia-inducible_factor_2alpha	14,45	sirtuin 1	hypoxia-inducible factor 2alpha	93759(Tax:10090)	13819(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY Regulation|acl|signaling Regulation|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor_2alpha signaling by the stress-responsive deacetylase sirtuin_1 .
21471201	0	sirtuin_1	149,158	mammalian_target_of_rapamycin	88,117	sirtuin 1	mammalian target of rapamycin	23411	2475	Gene	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|dep|Inhibition	Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian_target_of_rapamycin -LRB- mTOR -RRB- - dependent Inhibition of sirtuin_1 .
16484774	0	sirtuin_5	44,53	SIRT5	60,65	sirtuin 5	SIRT5	23408	23408	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the NAD-dependent deacetylase sirtuin_5 gene -LRB- SIRT5 -RRB- to human chromosome band 6p23 by in situ hybridization .
10944850	0	site-1_protease	55,70	S1P	72,75	site-1 protease	S1P	8720	8720	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosomal mapping of the human site-1_protease -LRB- S1P -RRB- gene .
20304921	0	six_transmembrane_epithelial_antigen_of_prostate_4	22,72	STEAP4	74,80	six transmembrane epithelial antigen of prostate 4	STEAP4	117167(Tax:10090)	117167(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of hepatic six_transmembrane_epithelial_antigen_of_prostate_4 -LRB- STEAP4 -RRB- expression by STAT3 and CCAAT/enhancer-binding protein alpha .
21044749	0	six_transmembrane_epithelial_antigen_of_prostate_4	14,64	STEAP4	66,72	six transmembrane epithelial antigen of prostate 4	STEAP4	79689	79689	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Variations of six_transmembrane_epithelial_antigen_of_prostate_4 -LRB- STEAP4 -RRB- gene are associated with metabolic_syndrome in a female Uygur general population .
23262293	0	six_transmembrane_epithelial_antigen_of_prostate_4	62,112	STEAP4	114,120	six transmembrane epithelial antigen of prostate 4	STEAP4	117167(Tax:10090)	117167(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional analysis and transcriptional regulation of porcine six_transmembrane_epithelial_antigen_of_prostate_4 -LRB- STEAP4 -RRB- gene and its novel variant in hepatocytes .
12011100	0	skNAC	71,76	m-Bop	0,5	skNAC	m-Bop	17938(Tax:10090)	12180(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	m-Bop , a repressor protein essential for cardiogenesis , interacts with skNAC , a heart - and muscle-specific transcription factor .
14764074	0	skeletal_muscle_glycogen_synthase	30,63	GYS1	70,74	skeletal muscle glycogen synthase	GYS1	2997	2997	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Characterization of the human skeletal_muscle_glycogen_synthase gene -LRB- GYS1 -RRB- promoter .
8940056	0	skeletal_muscle_glycogen_synthase	45,78	Jun_N-terminal_kinase	0,21	skeletal muscle glycogen synthase	Jun N-terminal kinase	2997	5599	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	Jun_N-terminal_kinase mediates activation of skeletal_muscle_glycogen_synthase by insulin in vivo .
24400695	0	skeletal_muscle_ryanodine_receptor	26,60	IL-1a	0,5	skeletal muscle ryanodine receptor	IL-1a	6261	3552	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	IL-1a reversibly inhibits skeletal_muscle_ryanodine_receptor .
17376685	0	skeletal_muscle_ryanodine_receptor	65,99	RYR1	101,105	skeletal muscle ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Centronuclear_myopathy due to a de novo dominant mutation in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
19303294	0	skeletal_muscle_ryanodine_receptor	90,124	RYR1	126,130	skeletal muscle ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Late-onset axial_myopathy with cores due to a novel heterozygous dominant mutation in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
20080402	0	skeletal_muscle_ryanodine_receptor	94,128	RYR1	130,134	skeletal muscle ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Multi-minicore disease and atypical periodic_paralysis associated with novel mutations in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
20461000	0	skeletal_muscle_ryanodine_receptor	44,78	RYR1	22,26	skeletal muscle ryanodine receptor	RYR1	6261	6261	Gene	Gene	mutations|nmod|START_ENTITY mutations|nummod|END_ENTITY	Functional studies of RYR1 mutations in the skeletal_muscle_ryanodine_receptor using human RYR1 complementary DNA .
21514828	0	skeletal_muscle_ryanodine_receptor	59,93	RYR1	95,99	skeletal muscle ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	King-Denborough_syndrome with and without mutations in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
23329375	0	skeletal_muscle_ryanodine_receptor	67,101	RYR1	103,107	skeletal muscle ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel late-onset axial_myopathy associated with mutations in the skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
8661021	0	skeletal_muscle_ryanodine_receptor	41,75	RYR1	77,81	skeletal muscle ryanodine receptor	RYR1	6261	6261	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The structural organization of the human skeletal_muscle_ryanodine_receptor -LRB- RYR1 -RRB- gene .
9737879	0	skeletal_muscle_ryanodine_receptor	23,57	triadin	61,68	skeletal muscle ryanodine receptor	triadin	100009540(Tax:9986)	100009519(Tax:9986)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dual regulation of the skeletal_muscle_ryanodine_receptor by triadin and calsequestrin .
9534887	0	skin-derived_antileukoproteinase	14,46	SKALP	48,53	skin-derived antileukoproteinase	SKALP	5266	5266	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of skin-derived_antileukoproteinase -LRB- SKALP -RRB- in reconstructed human epidermis and its value as a marker for skin irritation .
8523512	0	skn-1a	107,113	Epoc-1	100,106	skn-1a	Epoc-1	25833	25833	Gene	Gene	Regulation|parataxis|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of human_papillomavirus transcription by the differentiation-dependent epithelial factor Epoc-1 / skn-1a .
10772955	0	skp2	86,90	kip1	103,107	skp2	kip1	6502	1027	Gene	Gene	SCF|appos|START_ENTITY SCF|nmod|p27 p27|appos|END_ENTITY	Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF -LRB- skp2 -RRB- toward p27 -LRB- kip1 -RRB- .
10772955	0	skp2	86,90	p27	99,102	skp2	p27	6502	10671	Gene	Gene	SCF|appos|START_ENTITY SCF|nmod|END_ENTITY	Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF -LRB- skp2 -RRB- toward p27 -LRB- kip1 -RRB- .
11152631	0	slbo	29,33	Jing	0,4	slbo	Jing	37889(Tax:7227)	35555(Tax:7227)	Gene	Gene	target|nmod|START_ENTITY END_ENTITY|dep|target	Jing : a downstream target of slbo required for developmental control of border cell migration .
15486076	0	slc22a5	75,82	octn2	68,73	slc22a5	octn2	6584	6584	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression , localization , and function of the carnitine transporter octn2 -LRB- slc22a5 -RRB- in human placenta .
25428902	0	slc39A14	20,28	ZIP14	13,18	slc39A14	ZIP14	213053(Tax:10090)	213053(Tax:10090)	Gene	Gene	Influence|appos|START_ENTITY Influence|nmod|END_ENTITY	Influence of ZIP14 -LRB- slc39A14 -RRB- on intestinal zinc processing and barrier function .
25208640	0	slimb	96,101	Debcl	36,41	slimb	Debcl	42504(Tax:7227)	53585(Tax:7227)	Gene	Gene	targeted|nmod|START_ENTITY targeted|nsubjpass|END_ENTITY	The drosophila Bcl-2 family protein Debcl is targeted to the proteasome by the b-TrCP homologue slimb .
17525203	0	slug	69,73	E-cadherin	43,53	slug	E-cadherin	6591	999	Gene	Gene	expression|amod|START_ENTITY production|nmod|expression production|amod|END_ENTITY	Transforming_growth_factor-beta1 represses E-cadherin production via slug expression in lens epithelial cells .
19389926	0	slug	144,148	E-cadherin	91,101	slug	E-cadherin	6591	999	Gene	Gene	transactivation|nmod|START_ENTITY modulating|nmod|transactivation modulating|dobj|expression expression|amod|END_ENTITY	Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis , modulating E-cadherin expression through the transactivation of slug .
25086032	0	slug	97,101	E-cadherin	134,144	slug	E-cadherin	6591	999	Gene	Gene	START_ENTITY|dobj|transcription transcription|nmod|degradation degradation|amod|END_ENTITY	Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation : dual role of scaffold/matrix _ attachment_region-binding_protein_1 -LRB- SMAR1 -RRB- in breast_cancer cells .
25086032	0	slug	97,101	E-cadherin	54,64	slug	E-cadherin	6591	999	Gene	Gene	repression|acl|START_ENTITY up-regulation|nmod|repression up-regulation|amod|END_ENTITY	Inhibition of epithelial to mesenchymal transition by E-cadherin up-regulation via repression of slug transcription and inhibition of E-cadherin degradation : dual role of scaffold/matrix _ attachment_region-binding_protein_1 -LRB- SMAR1 -RRB- in breast_cancer cells .
16924233	0	slug	121,125	tight_junction_protein_occludin	34,65	slug	tight junction protein occludin	6591	100506658	Gene	Gene	activation|nmod|START_ENTITY END_ENTITY|nmod|activation	Raf_1 represses expression of the tight_junction_protein_occludin via activation of the zinc-finger transcription factor slug .
9693045	0	sm22alpha	11,20	Tagln	22,27	sm22alpha	Tagln	21345(Tax:10090)	21345(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Paralogous sm22alpha -LRB- Tagln -RRB- genes map to mouse chromosomes 1 and 9 : further evidence for a paralogous relationship .
8570636	0	sma-2	29,34	sma-3	36,41	sma-2	sma-3	176229(Tax:6239)	175955(Tax:6239)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Caenorhabditis_elegans genes sma-2 , sma-3 , and sma-4 define a conserved family of transforming growth factor beta pathway components .
8570636	0	sma-3	36,41	sma-2	29,34	sma-3	sma-2	175955(Tax:6239)	176229(Tax:6239)	Gene	Gene	genes|nummod|START_ENTITY genes|nummod|END_ENTITY	Caenorhabditis_elegans genes sma-2 , sma-3 , and sma-4 define a conserved family of transforming growth factor beta pathway components .
15871184	0	smac	16,20	HSP70	1,6	smac	HSP70	66593(Tax:10090)	15511(Tax:10090)	Gene	Gene	release|amod|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	-LSB- HSP70 inhibits smac release from the mitochondria and protects against H2O2-induced apoptosis in C2C12 myogenic cells -RSB- .
15934312	0	smad2	53,58	TGFbeta1	23,31	smad2	TGFbeta1	29357(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Influence of exogenous TGFbeta1 on the expression of smad2 and smad3 in rat bone marrow-derived mesenchymal stem cells .
10767528	0	smad2	42,47	smad3	49,54	smad2	smad3	30639(Tax:7955)	58092(Tax:7955)	Gene	Gene	zebrafish|nummod|START_ENTITY zebrafish|nummod|END_ENTITY	Cloning and characterization of zebrafish smad2 , smad3 and smad4 .
25374926	0	smad3	73,78	TGF-b	0,5	smad3	TGF-b	17127(Tax:10090)	21803(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|induction induction|amod|END_ENTITY	TGF-b induction of FGF-2 expression in stromal cells requires integrated smad3 and MAPK pathways .
10797313	0	smad3	15,20	TGF-beta	150,158	smad3	TGF-beta	4088	7040	Gene	Gene	Interaction|nmod|START_ENTITY _|nsubj|Interaction _|dobj|promoter promoter|acl|required required|nmod|END_ENTITY	Interaction of smad3 with a proximal smad-binding element of the human alpha2 -LRB- I -RRB- _ procollagen gene promoter required for transcriptional activation by TGF-beta .
10767528	0	smad3	49,54	smad2	42,47	smad3	smad2	58092(Tax:7955)	30639(Tax:7955)	Gene	Gene	zebrafish|nummod|START_ENTITY zebrafish|nummod|END_ENTITY	Cloning and characterization of zebrafish smad2 , smad3 and smad4 .
26531758	0	smad7	77,82	MicroRNA-21	0,11	smad7	MicroRNA-21	4092	406991	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	MicroRNA-21 induces breast_cancer cell invasion and migration by suppressing smad7 via EGF and TGF-b pathways .
18269587	0	small_breast_epithelial_mucin	14,43	SBEM	45,49	small breast epithelial mucin	SBEM	118430	118430	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of small_breast_epithelial_mucin -LRB- SBEM -RRB- protein in tissue microarrays -LRB- TMAs -RRB- of primary invasive breast_cancers .
14752053	0	small_heterodimer_partner	24,49	BETA2/neuroD	121,133	small heterodimer partner	BETA2/neuroD	8431	4760	Gene	Gene	START_ENTITY|appos|corepressor corepressor|nmod|END_ENTITY	Orphan nuclear receptor small_heterodimer_partner , a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD .
22577560	0	small_heterodimer_partner	51,76	orphan_nuclear_receptor	27,50	small heterodimer partner	orphan nuclear receptor	8431	2103	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A pleiotropic role for the orphan_nuclear_receptor small_heterodimer_partner in lipid homeostasis and metabolic pathways .
12805410	0	small_heterodimer_partner	4,29	pregnane_X_receptor	49,68	small heterodimer partner	pregnane X receptor	8431	8856	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The small_heterodimer_partner interacts with the pregnane_X_receptor and represses its transcriptional activity .
2071154	0	small_inducible_cytokine_A2	24,51	SCYA2	58,63	small inducible cytokine A2	SCYA2	6347	6347	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human small_inducible_cytokine_A2 gene , SCYA2 -LRB- encoding JE or MCP-1 -RRB- , to 17q11.2-12 : evolutionary relatedness of cytokines clustered at the same locus .
22004728	0	small_leucine_zipper_protein	54,82	ADP-ribosylation_factor_4	14,39	small leucine zipper protein	ADP-ribosylation factor 4	10488	378	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of ADP-ribosylation_factor_4 expression by small_leucine_zipper_protein and involvement in breast_cancer cell migration .
10617653	0	small_nuclear_RING_finger_protein	12,45	Sp1	63,66	small nuclear RING finger protein	Sp1	6047	6667	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Coregulator small_nuclear_RING_finger_protein -LRB- SNURF -RRB- enhances Sp1 - and steroid receptor-mediated transcription by different mechanisms .
8384302	0	smg_p25A	44,52	p25	59,62	smg p25A	p25	282029(Tax:9913)	280968(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Rabphilin-3A , a putative target protein for smg_p25A / rab3A p25 small GTP-binding protein related to synaptotagmin .
8384302	0	smg_p25A	44,52	rab3A	53,58	smg p25A	rab3A	282029(Tax:9913)	282029(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Rabphilin-3A , a putative target protein for smg_p25A / rab3A p25 small GTP-binding protein related to synaptotagmin .
9354432	0	smoh	65,69	Patched	0,7	smoh	Patched	6608	5727	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Patched -LRB- ptch -RRB- - associated preferential expression of smoothened -LRB- smoh -RRB- in human basal_cell_carcinoma_of_the_skin .
21074607	0	smooth_muscle_a-actin	39,60	NADPH_oxidase_4	0,15	smooth muscle a-actin	NADPH oxidase 4	6606	50507	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	NADPH_oxidase_4 mediates TGF-b-induced smooth_muscle_a-actin via p38MAPK and serum_response_factor .
19608972	0	smooth_muscle_alpha-actin	59,84	Sphingosine-1-phosphate_receptor-2	0,34	smooth muscle alpha-actin	Sphingosine-1-phosphate receptor-2	20589(Tax:10090)	14739(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sphingosine-1-phosphate_receptor-2 regulates expression of smooth_muscle_alpha-actin after arterial_injury .
9314842	0	smooth_muscle_alpha-actin	38,63	serum_response_factor	78,99	smooth muscle alpha-actin	serum response factor	81633(Tax:10116)	501099(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulation|nmod|expression stimulation|nmod|END_ENTITY	Angiotensin_II-induced stimulation of smooth_muscle_alpha-actin expression by serum_response_factor and the homeodomain transcription factor MHox .
15327999	0	smoothelin	74,84	CHASM	45,50	smoothelin	CHASM	6525	219537	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Modulation of smooth muscle contractility by CHASM , a novel member of the smoothelin family of proteins .
23033319	0	smoothelin	19,29	SMTN	31,35	smoothelin	SMTN	6525	6525	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the smoothelin -LRB- SMTN -RRB- gene with cerebral_infarction in men : a haplotype-based case-control study .
10965129	0	smoothelin	53,63	Smtn	37,41	smoothelin	Smtn	29856(Tax:10090)	29856(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	Structure and chromosome location of Smtn , the mouse smoothelin gene .
17960137	0	smoothened	19,29	Hedgehog	0,8	smoothened	Hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	activity|amod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Hedgehog regulates smoothened activity by inducing a conformational switch .
20375059	0	smoothened	74,84	Rab23	58,63	smoothened	Rab23	319757(Tax:10090)	19335(Tax:10090)	Gene	Gene	levels|amod|START_ENTITY regulates|dobj|levels regulates|nsubj|END_ENTITY	Differential role of Rab proteins in ciliary trafficking : Rab23 regulates smoothened levels .
8700230	0	smoothened	0,10	hedgehog	67,75	smoothened	hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	encodes|nsubj|START_ENTITY encodes|dobj|protein protein|acl|required required|advcl|END_ENTITY	smoothened encodes a receptor-like serpentine protein required for hedgehog signalling .
8706127	0	smoothened	15,25	hedgehog	98,106	smoothened	hedgehog	33196(Tax:7227)	42737(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY encodes|nsubj|gene encodes|dobj|protein protein|appos|receptor receptor|nmod|signal signal|amod|END_ENTITY	The Drosophila smoothened gene encodes a seven-pass membrane protein , a putative receptor for the hedgehog signal .
24502520	0	smoothened_receptor	52,71	SMO	73,76	smoothened receptor	SMO	6608	6608	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Development of a concise , asymmetric synthesis of a smoothened_receptor -LRB- SMO -RRB- inhibitor : enzymatic transamination of a 4-piperidinone with dynamic kinetic resolution .
12065578	0	sn-glycerol-3-phosphate_acyltransferase	52,91	AMP-activated_protein_kinase	123,151	sn-glycerol-3-phosphate acyltransferase	AMP-activated protein kinase	29653(Tax:10116)	78975(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Coordinate regulation of malonyl-CoA_decarboxylase , sn-glycerol-3-phosphate_acyltransferase , and acetyl-CoA carboxylase by AMP-activated_protein_kinase in rat tissues in response to exercise .
26725010	0	snRNP	28,33	KAP1	0,4	snRNP	KAP1	57819	10155	Gene	Gene	Recruitment|nmod|START_ENTITY Recruitment|compound|END_ENTITY	KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II .
26479860	0	snRNP	63,68	U11	59,62	snRNP	U11	57819	26824	Gene	Gene	mediate|compound|START_ENTITY mediate|compound|END_ENTITY	Evolutionarily conserved exon definition interactions with U11 snRNP mediate alternative splicing regulation on U11-48K and U11/U12 -65 K genes .
17576664	0	snRNP	57,62	p100	37,41	snRNP	p100	57819	27044	Gene	Gene	proteins|compound|START_ENTITY interacts|nmod|proteins interacts|nsubj|END_ENTITY	Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome .
26729198	0	snai1	39,44	miR-204	0,7	snai1	miR-204	6615	406987	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-204 regulates the EMT by targeting snai1 to suppress the invasion and migration of gastric_cancer .
23288509	0	snail	13,18	ALX1	0,4	snail	ALX1	6615	8092	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	ALX1 induces snail expression to promote epithelial-to-mesenchymal transition and invasion of ovarian_cancer cells .
26722397	0	snail	77,82	ALX1	0,4	snail	ALX1	6615	8092	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|nsubj|END_ENTITY	ALX1 promotes migration and invasion of lung_cancer cells through increasing snail expression .
25502082	0	snail	16,21	B-Myb	0,5	snail	B-Myb	6615	4605	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	B-Myb regulates snail expression to promote epithelial-to-mesenchymal transition and invasion of breast_cancer cell .
20305697	0	snail	68,73	CK1	8,11	snail	CK1	6615	3848	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail .
10655586	0	snail	25,30	E-cadherin	89,99	snail	E-cadherin	20613(Tax:10090)	12550(Tax:10090)	Gene	Gene	controls|nsubj|START_ENTITY controls|advcl|repressing repressing|dobj|expression expression|amod|END_ENTITY	The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression .
10655587	0	snail	25,30	E-cadherin	49,59	snail	E-cadherin	6615	999	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|expression expression|amod|END_ENTITY	The transcription factor snail is a repressor of E-cadherin gene expression in epithelial_tumour cells .
11244511	0	snail	143,148	E-cadherin	121,131	snail	E-cadherin	6615	999	Gene	Gene	suppresses|parataxis|START_ENTITY suppresses|dobj|transcription transcription|nmod|repressor repressor|amod|END_ENTITY	Inhibition of integrin_linked_kinase -LRB- ILK -RRB- suppresses beta-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor , snail , in APC - / - human colon_carcinoma cells .
16849535	0	snail	65,70	E-cadherin	51,61	snail	E-cadherin	6615	999	Gene	Gene	interfere|nmod|START_ENTITY interfere|nmod|repression repression|nmod|END_ENTITY	SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug : a potential mechanism for aberrant mesenchymal to epithelial transition in human synovial_sarcoma .
18321996	0	snail	127,132	E-cadherin	70,80	snail	E-cadherin	6615	999	Gene	Gene	induction|nmod|START_ENTITY down-regulates|nmod|induction down-regulates|dobj|END_ENTITY	Inhibition of CCN6 -LRB- Wnt-1-induced_signaling_protein_3 -RRB- down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1 .
22969242	0	snail	80,85	E-cadherin	45,55	snail	E-cadherin	6615	999	Gene	Gene	expression|compound|START_ENTITY enhancing|dobj|expression reduce|advcl|enhancing reduce|dobj|expression expression|amod|END_ENTITY	Prostaglandin_E -LRB- 2 -RRB- and interleukin-1b reduce E-cadherin expression by enhancing snail expression in gastric_cancer cells .
22199300	0	snail	45,50	EP4	27,30	snail	EP4	20613(Tax:10090)	19219(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY expression|nmod|signaling expression|compound|END_ENTITY	Modulation of PGE2-induced EP4 expression on snail signaling and the impact on epithelial-mesenchymal transition : significance of EP4 antagonism .
23979441	0	snail	16,21	HIF-1a	71,77	snail	HIF-1a	6615	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Hypoxia-induced snail expression through transcriptional regulation by HIF-1a in pancreatic_cancer cells .
15833848	0	snail	100,105	Pak1	0,4	snail	Pak1	6615	5058	Gene	Gene	localization|nmod:poss|START_ENTITY modulates|dobj|localization modulates|nsubj|phosphorylation phosphorylation|amod|END_ENTITY	Pak1 phosphorylation of snail , a master regulator of epithelial-to-mesenchyme transition , modulates snail 's subcellular localization and functions .
15833848	0	snail	24,29	Pak1	0,4	snail	Pak1	6615	5058	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Pak1 phosphorylation of snail , a master regulator of epithelial-to-mesenchyme transition , modulates snail 's subcellular localization and functions .
18234959	0	snail	108,113	Transforming_growth_factor-beta_1	0,33	snail	Transforming growth factor-beta 1	6615	7040	Gene	Gene	expression|compound|START_ENTITY promotes|nmod|expression promotes|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 promotes matrix_metalloproteinase-9-mediated oral_cancer invasion through snail expression .
25280941	0	snail	13,18	XBP1	0,4	snail	XBP1	6615	7494	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	XBP1 induces snail expression to promote epithelial - to-mesenchymal transition and invasion of breast_cancer cells .
19208738	0	snail	39,44	Yin_yang_1	0,10	snail	Yin yang 1	6615	7528	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Yin_yang_1 regulates the expression of snail through a distal enhancer .
1533042	0	snail	56,61	single-minded	77,90	snail	single-minded	34908(Tax:7227)	41612(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|nmod|gene gene|amod|END_ENTITY	Dorsal-ventral patterning in Drosophila : DNA binding of snail protein to the single-minded gene .
1803271	0	snail	109,114	vasopressin	26,37	snail	vasopressin	6615	551	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of an analog of vasopressin on the reaction of command neurons of defensive behavior of the edible snail during the stimulation of nerves .
2174617	0	snail	115,120	vasopressin	17,28	snail	vasopressin	6615	551	Gene	Gene	behavior|nmod|START_ENTITY neurons|nmod|behavior neurons|csubj|-LSB- -LSB-|dobj|effect effect|nmod|analog analog|compound|END_ENTITY	-LSB- The effect of a vasopressin analog on the reaction of the command neurons in the defensive behavior of the edible snail during nerve stimulation -RSB- .
15102850	0	snapin	18,24	BLOS1	51,56	snapin	BLOS1	20615(Tax:10090)	14533(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of snapin and three novel proteins -LRB- BLOS1 , BLOS2 , and BLOS3/reduced pigmentation -RRB- as subunits of biogenesis_of_lysosome-related_organelles_complex-1 -LRB- BLOC-1 -RRB- .
18166085	0	snoRNA	24,30	MBII-85	16,23	snoRNA	MBII-85	85389	100616072	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal_growth_retardation .
20588305	0	snoRNA	99,105	SNORD116	82,90	snoRNA	SNORD116	85391	692236	Gene	Gene	cluster|compound|START_ENTITY cluster|compound|END_ENTITY	Paternally inherited microdeletion at 15q11 .2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader-Willi_syndrome .
19482358	0	socs1	40,45	Sp2	0,3	socs1	Sp2	8651	6668	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Sp2 regulates interferon-gamma-mediated socs1 gene expression .
21167140	0	sod1	10,14	atp7a	74,79	sod1	atp7a	30553(Tax:7955)	564924(Tax:7955)	Gene	Gene	modulated|nsubjpass|START_ENTITY modulated|nmod|END_ENTITY	Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper_status .
20069550	0	sodium-dependent_glucose_co-transporter	93,132	SGLT1	133,138	sodium-dependent glucose co-transporter	SGLT1	100008981(Tax:9986)	100008981(Tax:9986)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Protein kinase C mediated intracellular signaling pathways are involved in the regulation of sodium-dependent_glucose_co-transporter SGLT1 activity .
19700318	0	sodium-dependent_glucose_co-transporter_2	35,76	SGLT2	78,83	sodium-dependent glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	O-Spiro_C-aryl_glucosides as novel sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
19896374	0	sodium-dependent_glucose_co-transporter_2	74,115	SGLT2	117,122	sodium-dependent glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Exploration of O-spiroketal_C-arylglucosides as novel and selective renal sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
20576578	0	sodium-dependent_glucose_co-transporter_2	73,114	SGLT2	116,121	sodium-dependent glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	ortho-Substituted_C-aryl_glucosides as highly potent and selective renal sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
21090651	0	sodium-dependent_glucose_co-transporter_2	27,68	SGLT2	70,75	sodium-dependent glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of non-glycoside sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors by ligand-based virtual screening .
21737266	0	sodium-dependent_glucose_co-transporter_2	79,120	SGLT2	122,127	sodium-dependent glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	C-aryl_glucosides substituted at the 4 ' - position as potent and selective renal sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors for the treatment of type 2 diabetes .
22120948	0	sodium-dependent_glucose_co-transporter_2	34,75	SGLT2	77,82	sodium-dependent glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	A specific pharmacophore model of sodium-dependent_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
18260618	0	sodium-dependent_glucose_cotransporter_2	54,94	SGLT2	96,101	sodium-dependent glucose cotransporter 2	SGLT2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Discovery of dapagliflozin : a potent , selective renal sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
19785435	0	sodium-dependent_glucose_cotransporter_2	40,80	SGLT2	82,87	sodium-dependent glucose cotransporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel L-xylose derivatives as selective sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitors for the treatment of type 2 diabetes .
20180760	0	sodium-dependent_glucose_cotransporter_2	6,46	SGLT2	48,53	sodium-dependent glucose cotransporter 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Renal sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitors for new anti-diabetic agent .
21873071	0	sodium-dependent_glucose_cotransporter_2	48,88	SGLT2	90,95	sodium-dependent glucose cotransporter 2	SGLT2	246787(Tax:10090)	246787(Tax:10090)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	5a-Carba-b-D-glucopyranose derivatives as novel sodium-dependent_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitors for the treatment of type 2 diabetes .
9109390	0	sodium-glucose-linked_transporter	47,80	SGLT1	82,87	sodium-glucose-linked transporter	SGLT1	25552(Tax:10116)	25552(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transcriptional and translational control over sodium-glucose-linked_transporter -LRB- SGLT1 -RRB- gene expression in adult rat small intestine .
26209767	0	sodium-glucose_co-transporter_2	64,95	SGLT-2	97,103	sodium-glucose co-transporter 2	SGLT-2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A quantitative LC-MS/MS method for determining ipragliflozin , a sodium-glucose_co-transporter_2 -LRB- SGLT-2 -RRB- inhibitor , and its application to a pharmacokinetic study in rats .
26989857	0	sodium-glucose_co-transporter_2	70,101	SGLT-2	103,109	sodium-glucose co-transporter 2	SGLT-2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	A validated LC-MS/MS method for the determination of canagliflozin , a sodium-glucose_co-transporter_2 -LRB- SGLT-2 -RRB- inhibitor , in a lower volume of rat plasma : application to pharmacokinetic studies in rats .
24991224	0	sodium-glucose_co-transporter_2	21,52	SGLT2	54,59	sodium-glucose co-transporter 2	SGLT2	6524	6524	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Empagliflozin : a new sodium-glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitor for the treatment of type 2 diabetes .
22429686	0	sodium-glucose_cotransporter	31,59	SGLT2	61,66	sodium-glucose cotransporter	SGLT2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ursodeoxycholic_acid decreases sodium-glucose_cotransporter -LRB- SGLT2 -RRB- expression and oxidative stress in the kidney of diabetic rats .
23563279	0	sodium-glucose_cotransporter-2	24,54	SGLT2	56,61	sodium-glucose cotransporter-2	SGLT2	6524	6524	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|appos|END_ENTITY	Ipragliflozin and other sodium-glucose_cotransporter-2 -LRB- SGLT2 -RRB- inhibitors in the treatment of type 2 diabetes : preclinical and clinical data .
24829965	0	sodium-glucose_cotransporter_2	59,89	SGLT-2	91,97	sodium-glucose cotransporter 2	SGLT-2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	The safety of dipeptidyl_peptidase-4 -LRB- DPP-4 -RRB- inhibitors or sodium-glucose_cotransporter_2 -LRB- SGLT-2 -RRB- inhibitors added to metformin background therapy in patients with type_2_diabetes_mellitus : a systematic review and meta-analysis .
21410690	0	sodium-glucose_cotransporter_2	46,76	SGLT2	78,83	sodium-glucose cotransporter 2	SGLT2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	TS-071 is a novel , potent and selective renal sodium-glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor with anti-hyperglycaemic activity .
21606218	0	sodium-glucose_cotransporter_2	8,38	SGLT_2	40,46	sodium-glucose cotransporter 2	SGLT 2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Role of sodium-glucose_cotransporter_2 -LRB- SGLT_2 -RRB- inhibitors in the treatment of type 2 diabetes .
24420910	0	sodium-glucose_cotransporters_type_2	28,64	SGLT2	66,71	sodium-glucose cotransporters type 2	SGLT2	6524	6524	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Drug-drug interactions with sodium-glucose_cotransporters_type_2 -LRB- SGLT2 -RRB- inhibitors , new oral glucose-lowering agents for the management of type_2_diabetes_mellitus .
7675626	0	sodium-glucose_transporter	42,68	SGLT1	70,75	sodium-glucose transporter	SGLT1	25552(Tax:10116)	25552(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The effects of streptozotocin diabetes on sodium-glucose_transporter -LRB- SGLT1 -RRB- expression and function in rat jejunal and ileal villus-attached enterocytes .
8812438	0	sodium_channel_alpha-subunit	6,34	Scn9a	41,46	sodium channel alpha-subunit	Scn9a	110880(Tax:10090)	20274(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A new sodium_channel_alpha-subunit gene -LRB- Scn9a -RRB- from Schwann cells maps to the Scn1a , Scn2a , Scn3a cluster of mouse chromosome 2 .
16380256	0	sodium_glucose_co-transporter_2	27,58	SGLT2	60,65	sodium glucose co-transporter 2	SGLT2	64522(Tax:10116)	64522(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Indole-glucosides as novel sodium_glucose_co-transporter_2 -LRB- SGLT2 -RRB- inhibitors .
23253948	0	sodium_glucose_cotransporter-2	37,67	SGLT2	69,74	sodium glucose cotransporter-2	SGLT2	6524	6524	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Pharmacokinetics of empagliflozin , a sodium_glucose_cotransporter-2 -LRB- SGLT2 -RRB- inhibitor , and metformin following co-administration in healthy volunteers .
24964723	0	sodium_glucose_cotransporter_2	49,79	SGLT2	81,86	sodium glucose cotransporter 2	SGLT2	6524	6524	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	Exposure-response modelling for empagliflozin , a sodium_glucose_cotransporter_2 -LRB- SGLT2 -RRB- inhibitor , in patients with type 2 diabetes .
16218878	0	sodium_taurocholate_cotransporting_polypeptide	19,65	NTCP	67,71	sodium taurocholate cotransporting polypeptide	NTCP	6554	6554	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|appos|END_ENTITY	Degradation of the sodium_taurocholate_cotransporting_polypeptide -LRB- NTCP -RRB- by the ubiquitin-proteasome system .
10871044	0	soluble_aminopeptidase_P	50,74	XPNPEP1	81,88	soluble aminopeptidase P	XPNPEP1	7511	7511	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning , chromosomal sublocalization of the human soluble_aminopeptidase_P gene -LRB- XPNPEP1 -RRB- to 10q25 .3 and conservation of the putative proton shuttle and metal ligand binding sites with XPNPEP2 .
17495027	0	soluble_epoxide_hydrolase	28,53	Angiotensin_II	0,14	soluble epoxide hydrolase	Angiotensin II	65030(Tax:10116)	24179(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Angiotensin_II up-regulates soluble_epoxide_hydrolase in vascular endothelium in vitro and in vivo .
23454652	0	soluble_epoxide_hydrolase	125,150	CYP2C23	152,159	soluble epoxide hydrolase	CYP2C23	65030(Tax:10116)	83790(Tax:10116)	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	5,14-HEDGE , a 20-HETE mimetic , reverses hypotension and improves survival in a rodent model of septic_shock : contribution of soluble_epoxide_hydrolase , CYP2C23 , MEK1/ERK1/2 / IKKb/IkB-a/NF-kB pathway , and proinflammatory cytokine formation .
21479549	0	soluble_epoxide_hydrolase	95,120	sEH	122,125	soluble epoxide hydrolase	sEH	2053	2053	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble_epoxide_hydrolase -LRB- sEH -RRB- inhibitors .
23045145	0	soluble_epoxide_hydrolase	15,40	sEH	42,45	soluble epoxide hydrolase	sEH	2053	2053	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Measurement of soluble_epoxide_hydrolase -LRB- sEH -RRB- activity .
9038227	0	soluble_guanylate_cyclase	30,55	Nerve_growth_factor	0,19	soluble guanylate cyclase	Nerve growth factor	25206(Tax:10116)	310738(Tax:10116)	Gene	Gene	decreases|dobj|START_ENTITY decreases|nsubj|END_ENTITY	Nerve_growth_factor decreases soluble_guanylate_cyclase in rat pheochromocytoma PC12 cells .
10578147	0	soluble_guanylyl_cyclase	83,107	YC-1	61,65	soluble guanylyl cyclase	YC-1	497757(Tax:10116)	24421(Tax:10116)	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	Release of nitric_oxide from endothelial cells stimulated by YC-1 , an activator of soluble_guanylyl_cyclase .
23093275	0	soluble_mesothelin-related_protein	58,92	SMRP	94,98	soluble mesothelin-related protein	SMRP	10232	10232	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	A predictive equation to adjust for clinical variables in soluble_mesothelin-related_protein -LRB- SMRP -RRB- levels .
24157454	0	solute_carrier_2A2	66,84	Slc2a2	86,92	solute carrier 2A2	Slc2a2	25351(Tax:10116)	25351(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hepatocyte nuclear factors 1a/4a and forkhead_box_A2 regulate the solute_carrier_2A2 -LRB- Slc2a2 -RRB- gene expression in the liver and kidney of diabetic rats .
15950021	0	solute_carrier_family_1-member_3	32,64	SLC1A3	66,72	solute carrier family 1-member 3	SLC1A3	6507	6507	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A family based study implicates solute_carrier_family_1-member_3 -LRB- SLC1A3 -RRB- gene in attention-deficit/hyperactivity _ disorder .
17378896	0	solute_carrier_family_11_member_1	10,43	SLC11A1	53,60	solute carrier family 11 member 1	SLC11A1	6556	6556	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The human solute_carrier_family_11_member_1 protein -LRB- SLC11A1 -RRB- : linking infections , autoimmunity and cancer ?
20338449	0	solute_carrier_family_11_member_1	64,97	SLC11A1	99,106	solute carrier family 11 member 1	SLC11A1	282470(Tax:9913)	282470(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of single nucleotide polymorphisms in the bovine solute_carrier_family_11_member_1 -LRB- SLC11A1 -RRB- gene and their association with infection by Mycobacterium_avium subspecies paratuberculosis .
17065791	0	solute_carrier_family_27_member_1	57,90	SLC27A1	92,99	solute carrier family 27 member 1	SLC27A1	513787(Tax:9913)	513787(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural and functional characterization of the bovine solute_carrier_family_27_member_1 -LRB- SLC27A1 -RRB- gene .
16340170	0	solute_carrier_family_6_member_18	39,72	SLC6A18	74,81	solute carrier family 6 member 18	SLC6A18	22598(Tax:10090)	22598(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A nonsense polymorphism -LRB- Y319X -RRB- of the solute_carrier_family_6_member_18 -LRB- SLC6A18 -RRB- gene is not associated with hypertension and blood pressure in Japanese .
23114911	0	somatic_cell_score	59,77	MBL1	88,92	somatic cell score	MBL1	100532666	497014(Tax:9913)	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	SNPs identification and its correlation analysis with milk somatic_cell_score in bovine MBL1 gene .
711693	0	somatomedin	17,28	multiplication-stimulating_activity	42,77	somatomedin	multiplication-stimulating activity	100008668(Tax:9986)	24483(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|nmod|END_ENTITY	Demonstration of somatomedin activity of `` multiplication-stimulating_activity '' in rabbit costal chondrocytes in culture .
217513	0	somatomedin	35,46	prolactin	16,25	somatomedin	prolactin	24482(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of ovine prolactin on serum somatomedin bioactivity in hypophysectomized female rats .
1342592	0	somatomedin-C	56,69	growth_hormone	96,110	somatomedin-C	growth hormone	3479	2688	Gene	Gene	generation|amod|START_ENTITY generation|nmod|END_ENTITY	Effects of testosterone on growth_hormone secretion and somatomedin-C generation in prepubertal growth_hormone deficient male patients .
2033295	0	somatomedin-C	55,68	growth_hormone	39,53	somatomedin-C	growth hormone	3479	2688	Gene	Gene	level|amod|START_ENTITY level|nmod|END_ENTITY	Correlation between the level of serum growth_hormone ; somatomedin-C ; anthropometric measurements and the liver functions in chronic liver_diseases .
6749882	0	somatomedin-C	52,65	insulin-like_growth_factor-I	23,51	somatomedin-C	insulin-like growth factor-I	3479	3479	Gene	Gene	Characterization|dep|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of an insulin-like_growth_factor-I / somatomedin-C radioimmunoassay specific for the C-peptide region .
22262087	0	somatomedin_B	37,50	ENPP1	62,67	somatomedin B	ENPP1	7448	5167	Gene	Gene	domains|amod|START_ENTITY domains|nmod|END_ENTITY	In silico analysis of the two tandem somatomedin_B domains of ENPP1 reveals hints on the homodimerization of the protein .
6207196	0	somatomedin_B	46,59	serum_spreading_factor	6,28	somatomedin B	serum spreading factor	7448	7448	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Human serum_spreading_factor : relationship to somatomedin_B .
15157085	0	somatomedin_B	54,67	vitronectin	84,95	somatomedin B	vitronectin	7448	7448	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Disulfide bonding arrangements in active forms of the somatomedin_B domain of human vitronectin .
15173163	0	somatomedin_B	52,65	vitronectin	83,94	somatomedin B	vitronectin	7448	7448	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	Assignment of the four disulfides in the N-terminal somatomedin_B domain of native vitronectin isolated from human plasma .
16519524	0	somatomedin_B	23,36	vitronectin	47,58	somatomedin B	vitronectin	7448	7448	Gene	Gene	domain|compound|START_ENTITY domain|nmod|END_ENTITY	The reduced , denatured somatomedin_B domain of vitronectin refolds into a stable , biologically active molecule .
17189256	0	somatomedin_B	46,59	vitronectin	76,87	somatomedin B	vitronectin	7448	7448	Gene	Gene	domain|amod|START_ENTITY domain|nmod|END_ENTITY	Defining the native disulfide topology in the somatomedin_B domain of human vitronectin .
17344041	0	somatomedin_B	25,38	vitronectin	49,60	somatomedin B	vitronectin	7448	7448	Gene	Gene	region|amod|START_ENTITY region|nmod|END_ENTITY	The uPA receptor and the somatomedin_B region of vitronectin direct the localization of uPA to focal adhesions in microvessel endothelial cells .
2523786	0	somatomedin_C	25,38	IGF-1	40,45	somatomedin C	IGF-1	3479	3479	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Insulin increases plasma somatomedin_C -LRB- IGF-1 -RRB- concentrations in adult type 1 diabetic patients .
2850224	0	somatomedin_C	62,75	IGF-1	55,60	somatomedin C	IGF-1	3479	3479	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Studies on the roles of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- / somatomedin_C -LRB- SMC -RRB- during pregnancy -RSB- .
8730136	0	somatomedin_C	30,43	Insulin-like_growth_factor-I	0,28	somatomedin C	Insulin-like growth factor-I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Insulin-like_growth_factor-I -LRB- somatomedin_C -RRB- levels in chronic_fatigue_syndrome and fibromyalgia .
3926476	0	somatomedin_C	14,27	growth_hormone	86,100	somatomedin C	growth hormone	3479	2688	Gene	Gene	responses|amod|START_ENTITY responses|nmod|END_ENTITY	Plasma GH and somatomedin_C responses to single and repeated administrations of human growth_hormone releasing factor -LRB- hGRF -RRB- .
2850224	0	somatomedin_C	62,75	insulin-like_growth_factor-1	25,53	somatomedin C	insulin-like growth factor-1	3479	3479	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Studies on the roles of insulin-like_growth_factor-1 -LRB- IGF-1 -RRB- / somatomedin_C -LRB- SMC -RRB- during pregnancy -RSB- .
7674231	0	somatomedin_C	24,37	insulin-like_growth_factor_I	38,66	somatomedin C	insulin-like growth factor I	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Cyclosporin_A increases somatomedin_C insulin-like_growth_factor_I levels in chronic rheumatic_diseases .
7709860	0	somatomedin_c	86,99	IGF-1	101,106	somatomedin c	IGF-1	3479	3479	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Prevalence of malaria and its relationship to anemia , blood glucose levels , and serum somatomedin_c -LRB- IGF-1 -RRB- levels in the Solomon Islands .
9575857	0	somatostatin	32,44	CCK	58,61	somatostatin	CCK	443006(Tax:9940)	101116683	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of fundic and antral somatostatin secretion by CCK and gastrin .
2573431	0	somatostatin	22,34	CREB	76,80	somatostatin	CREB	24797(Tax:10116)	81646(Tax:10116)	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Cyclic_AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133 .
7799950	0	somatostatin	109,121	CREB	54,58	somatostatin	CREB	24797(Tax:10116)	81646(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene repressor|nmod|transcription END_ENTITY|dobj|repressor	Impaired cyclic_AMP-dependent phosphorylation renders CREB a repressor of C/EBP-induced transcription of the somatostatin gene in an insulinoma cell line .
1974080	0	somatostatin	13,25	EGF	55,58	somatostatin	EGF	6750	1950	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of somatostatin and epidermal_growth_factor -LRB- EGF -RRB- on the proliferation of thyroid follicular cells in organ culture .
2894712	0	somatostatin	13,25	EGF	55,58	somatostatin	EGF	24797(Tax:10116)	25313(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of somatostatin and epidermal_growth_factor -LRB- EGF -RRB- on the proliferation of follicular cells in the organ-cultured rat thyroid .
1973420	0	somatostatin	31,43	GH	100,102	somatostatin	GH	6750	2688	Gene	Gene	effects|nmod|START_ENTITY effects|parataxis|releasing releasing|dobj|stimulation stimulation|nmod|secretion secretion|compound|END_ENTITY	Impaired inhibitory effects of somatostatin on growth_hormone -LRB- GH -RRB- - releasing hormone stimulation of GH secretion after short term infusion .
1973420	0	somatostatin	31,43	GH	63,65	somatostatin	GH	6750	2688	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Impaired inhibitory effects of somatostatin on growth_hormone -LRB- GH -RRB- - releasing hormone stimulation of GH secretion after short term infusion .
2566942	0	somatostatin	241,253	GH	129,131	somatostatin	GH	6750	2688	Gene	Gene	release|nmod|START_ENTITY act|nmod|release man|appos|act releasing|nmod|man effect|acl|releasing effect|appos|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2566942	0	somatostatin	241,253	GH	159,161	somatostatin	GH	6750	2688	Gene	Gene	release|nmod|START_ENTITY act|nmod|release man|appos|act releasing|nmod|man releasing|dobj|secretion secretion|compound|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2906083	0	somatostatin	53,65	GH	39,41	somatostatin	GH	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	infusion|compound|START_ENTITY release|nmod|infusion release|appos|END_ENTITY	The rebound release of growth_hormone -LRB- GH -RRB- following somatostatin infusion in rats involves hypothalamic GH-releasing_factor release .
2908268	0	somatostatin	137,149	GH	77,79	somatostatin	GH	6750	2688	Gene	Gene	factor|compound|START_ENTITY effects|nmod|factor studies|dep|effects studies|nmod|expression expression|amod|growth_hormone growth_hormone|dep|END_ENTITY	Quantitative in-situ hybridization histochemistry studies on growth_hormone -LRB- GH -RRB- gene expression in acromegalic somatotrophs : effects of somatostatin , GH-releasing factor and cortisol .
6146235	0	somatostatin	107,119	GH	37,39	somatostatin	GH	6750	2688	Gene	Gene	administration|nmod|START_ENTITY secretion|nmod|administration secretion|nsubj|Inhibition Inhibition|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Inhibition of foetal growth_hormone -LRB- GH -RRB- and thyrotrophin -LRB- TSH -RRB- secretion after maternal administration of somatostatin .
667280	0	somatostatin	10,22	GH	67,69	somatostatin	GH	6750	2688	Gene	Gene	Action|nmod|START_ENTITY Action|nmod|secretion secretion|appos|END_ENTITY	Action of somatostatin , levodopa and pyridoxine on growth_hormone -LRB- GH -RRB- secretion in newborn infants .
7901787	0	somatostatin	193,205	GH	42,44	somatostatin	GH	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY control|nmod|release evidence|nmod|control potentiates|parataxis|evidence potentiates|dobj|response response|appos|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
7788012	0	somatostatin	155,167	Growth_hormone	0,14	somatostatin	Growth hormone	6750	2688	Gene	Gene	increase|compound|START_ENTITY evidence|nmod|increase response|dep|evidence response|amod|END_ENTITY	Growth_hormone response to growth_hormone-releasing_hormone -LRB- GHRH -RRB- , insulin , clonidine and arginine after GHRH pretreatment in obese children : evidence of somatostatin increase ?
9518881	0	somatostatin	109,121	Growth_hormone	0,14	somatostatin	Growth hormone	403993(Tax:9615)	403795(Tax:9615)	Gene	Gene	infusion|compound|START_ENTITY effect|nmod|infusion responses|dep|effect responses|amod|END_ENTITY	Growth_hormone responses to growth_hormone-releasing_hormone and hexarelin in fed and fasted dogs : effect of somatostatin infusion or pretreatment with pirenzepine .
2893728	0	somatostatin	70,82	Growth_hormone-releasing_factor	0,31	somatostatin	Growth hormone-releasing factor	24797(Tax:10116)	29446(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulate|dobj|expression regulate|nsubj|END_ENTITY	Growth_hormone-releasing_factor and fibroblast growth factor regulate somatostatin gene expression .
12947725	0	somatostatin	11,23	IL-10	41,46	somatostatin	IL-10	24797(Tax:10116)	25325(Tax:10116)	Gene	Gene	START_ENTITY|nmod|modulation modulation|nmod|END_ENTITY	-LSB- Effect of somatostatin on modulation of IL-10 and TGF-beta_1 during acute pancreatitis -RSB- .
2875137	0	somatostatin	20,32	NPY	14,17	somatostatin	NPY	100730851	100724008	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	Topography of NPY - , somatostatin - , and VIP-immunoreactive , neuronal subpopulations in the guinea_pig celiac-superior mesenteric ganglion and their projection to the pylorus .
25019573	0	somatostatin	32,44	Pancreatic_polypeptide	0,22	somatostatin	Pancreatic polypeptide	20604(Tax:10090)	19064(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY inhibits|dobj|secretion inhibits|nsubj|END_ENTITY	Pancreatic_polypeptide inhibits somatostatin secretion .
7777168	0	somatostatin	42,54	SSTR1	26,31	somatostatin	SSTR1	24797(Tax:10116)	25033(Tax:10116)	Gene	Gene	subtypes|compound|START_ENTITY subtypes|compound|END_ENTITY	Patterns of expression of SSTR1 and SSTR2 somatostatin receptor subtypes in the hypothalamus of the adult rat : relationship to neuroendocrine function .
18521573	0	somatostatin	18,30	SSTR4	12,17	somatostatin	SSTR4	20604(Tax:10090)	20608(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Hippocampal SSTR4 somatostatin receptors control the selection of memory strategies .
12799848	0	somatostatin	14,26	Substance_P	1,12	somatostatin	Substance P	6750	6863	Gene	Gene	transmitters|compound|START_ENTITY END_ENTITY|appos|transmitters	-LSB- Substance_P , somatostatin and monoaminergic transmitters in the cerebrospinal fluid of patients with chronic idiopathic_trigeminal_neuralgia -RSB- .
9834121	0	somatostatin	22,34	Substance_P	0,11	somatostatin	Substance P	20604(Tax:10090)	21333(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Substance_P regulates somatostatin expression in inflammation .
18283262	0	somatostatin	11,23	VEGF	63,67	somatostatin	VEGF	6750	7422	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of somatostatin on vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from non-functioning pituitary tumoral cells incubated in vitro .
11597765	0	somatostatin	35,47	VIP	15,18	somatostatin	VIP	24797(Tax:10116)	117064(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Involvement of VIP on BDNF-induced somatostatin gene expression in cultured fetal rat cerebral cortical cells .
2881616	0	somatostatin	47,59	VIP	25,28	somatostatin	VIP	24797(Tax:10116)	117064(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	-LSB- Effect of forskolin and VIP on the release of somatostatin and the cAMP content of cultured rat diencephalon neurons -RSB- .
21143993	0	somatostatin	42,54	XAF1	0,4	somatostatin	XAF1	6750	54739	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate_cancer cells .
21143993	0	somatostatin	42,54	XAF1	58,62	somatostatin	XAF1	6750	54739	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate_cancer cells .
26009453	0	somatostatin	22,34	XAF1	38,42	somatostatin	XAF1	6750	54739	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Regulatory effects of somatostatin on XAF1 in prostate_cancer .
21184749	0	somatostatin	14,26	brain_derived_neurotrophic_factor	46,79	somatostatin	brain derived neurotrophic factor	24797(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of somatostatin gene expression by brain_derived_neurotrophic_factor in fetal rat cerebrocortical cells .
9533810	0	somatostatin	46,58	calcitonin_gene-related_peptide	11,42	somatostatin	calcitonin gene-related peptide	24797(Tax:10116)	24241(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of calcitonin_gene-related_peptide on somatostatin and gastrin gene expression in rat antrum .
7846294	0	somatostatin	48,60	cholecystokinin	21,36	somatostatin	cholecystokinin	6750	885	Gene	Gene	secretion|compound|START_ENTITY stimulated|dobj|secretion END_ENTITY|acl|stimulated	Loxiglumide inhibits cholecystokinin stimulated somatostatin secretion and simultaneously enhances gastric_acid secretion in humans .
1682134	0	somatostatin	14,26	gastrin	40,47	somatostatin	gastrin	443006(Tax:9940)	101119230	Gene	Gene	Regulation|nmod|START_ENTITY secretion|nsubj|Regulation secretion|nmod|END_ENTITY	Regulation of somatostatin secretion by gastrin - and acid-dependent mechanisms .
1683168	0	somatostatin	24,36	gastrin	62,69	somatostatin	gastrin	24797(Tax:10116)	25320(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY mediated|nsubjpass|secretion mediated|nmod|END_ENTITY	Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus .
2881824	0	somatostatin	49,61	gastrin	86,93	somatostatin	gastrin	494469(Tax:9823)	445524(Tax:9823)	Gene	Gene	secretion|compound|START_ENTITY secretion|nmod|secretion control|nmod|secretion control|nmod|END_ENTITY	Autonomic nervous control of fundic secretion of somatostatin and antral secretion of gastrin and somatostatin in pigs .
6141956	0	somatostatin	11,23	gastrin	73,80	somatostatin	gastrin	403993(Tax:9615)	100685087	Gene	Gene	Effect|nmod|START_ENTITY hydrochloric_acid|nsubj|Effect hydrochloric_acid|dobj|concentration concentration|compound|END_ENTITY	-LSB- Effect of somatostatin on gastric hydrochloric_acid secretion and serum gastrin concentration in the dog -RSB- .
6142851	0	somatostatin	13,25	gastrin	61,68	somatostatin	gastrin	403993(Tax:9615)	100685087	Gene	Gene	doses|nmod|START_ENTITY suppress|nsubj|doses suppress|dobj|levels levels|compound|END_ENTITY	Low doses of somatostatin do not suppress postprandial serum gastrin levels in dogs .
6151425	0	somatostatin	22,34	gastrin	64,71	somatostatin	gastrin	6750	2520	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Inhibitory effect of somatostatin on the secretion of duodenal gastrin -RSB- .
863377	0	somatostatin	49,61	gastrin	30,37	somatostatin	gastrin	101096911	105260099	Gene	Gene	induced|nmod|START_ENTITY induced|dobj|release release|compound|END_ENTITY	Inhibition of vagally induced gastrin release by somatostatin in cats .
913912	0	somatostatin	11,23	gastrin	34,41	somatostatin	gastrin	6750	2520	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of somatostatin and human gastrin I on the lower esophageal sphincter in man .
9886974	0	somatostatin	31,43	gastrin	53,60	somatostatin	gastrin	443006(Tax:9940)	101119230	Gene	Gene	elevation|nmod|START_ENTITY prevents|nsubj|elevation prevents|dobj|stimulation stimulation|compound|END_ENTITY	Concurrent elevation of fundic somatostatin prevents gastrin stimulation by GRP .
1138156	0	somatostatin	48,60	growth_hormone	64,78	somatostatin	growth hormone	6750	2688	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Dose-response study of the inhibiting effect of somatostatin on growth_hormone and insulin secretion in normal subjects and acromegalic patients .
11416047	0	somatostatin	98,110	growth_hormone	66,80	somatostatin	growth hormone	6750	2688	Gene	Gene	secretion|nmod|START_ENTITY END_ENTITY|nmod|secretion	A novel function of prolactin-releasing peptide in the control of growth_hormone via secretion of somatostatin from the hypothalamus .
12200751	0	somatostatin	36,48	growth_hormone	96,110	somatostatin	growth hormone	6750	2688	Gene	Gene	activity|compound|START_ENTITY inhibition|nmod|activity responsible|nsubj|inhibition responsible|nmod|response response|amod|END_ENTITY	Complete inhibition of hypothalamic somatostatin activity is only partially responsible for the growth_hormone response to strenuous exercise .
14977577	0	somatostatin	28,40	growth_hormone	10,24	somatostatin	growth hormone	6750	2688	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	The serum growth_hormone to somatostatin ratio is skewed upward in rheumatoid_arthritis patients .
15103227	0	somatostatin	27,39	growth_hormone	68,82	somatostatin	growth hormone	6750	2688	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor subtype|nsubj|Expression subtype|nmod|pituitary_tumors pituitary_tumors|amod|END_ENTITY	Expression and function of somatostatin receptor subtype 1 in human growth_hormone secreting pituitary_tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs .
15580171	0	somatostatin	74,86	growth_hormone	51,65	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	causes|nmod|START_ENTITY causes|dobj|END_ENTITY	Intermittent hypoxia causes a suppressed pituitary growth_hormone through somatostatin .
1675149	0	somatostatin	34,46	growth_hormone	66,80	somatostatin	growth hormone	6750	2688	Gene	Gene	precursor|compound|START_ENTITY precursor|nmod|pituitary_gland_tumor pituitary_gland_tumor|compound|END_ENTITY	-LSB- Presence and characterization of somatostatin precursor in human growth_hormone secreting pituitary_gland_tumor -RSB- .
1684144	2	somatostatin	78,90	growth_hormone	94,108	somatostatin	growth hormone	443006(Tax:9940)	443329(Tax:9940)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|levels levels|compound|END_ENTITY	Effect of somatostatin on growth_hormone and glucose levels .
1684229	0	somatostatin	9,21	growth_hormone	88,102	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	Roles|nmod|START_ENTITY stress|nsubj|Roles stress|dobj|inhibition inhibition|nmod|release release|amod|END_ENTITY	Roles of somatostatin and growth_hormone-releasing_factor in ether stress inhibition of growth_hormone release .
1969759	0	somatostatin	36,48	growth_hormone	52,66	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	infusions|nmod|START_ENTITY Effect|nmod|infusions Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of intermittent infusions of somatostatin on growth_hormone secretion in unrestrained male rats with hypothalamic deafferentation .
1976218	0	somatostatin	22,34	growth_hormone	38,52	somatostatin	growth hormone	6750	2688	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|amod|END_ENTITY	Physiological role of somatostatin on growth_hormone regulation in humans .
23696563	0	somatostatin	11,23	growth_hormone	85,99	somatostatin	growth hormone	20604(Tax:10090)	14599(Tax:10090)	Gene	Gene	critical|nsubj|START_ENTITY critical|advcl|regulating regulating|nmod|release release|compound|END_ENTITY	Endogenous somatostatin is critical in regulating the acute effects of L-arginine on growth_hormone and insulin release in mice .
23855876	0	somatostatin	29,41	growth_hormone	119,133	somatostatin	growth hormone	20604(Tax:10090)	14599(Tax:10090)	Gene	Gene	mRNA|compound|START_ENTITY distribution|nmod|mRNA neurones|nsubj|distribution neurones|nmod|secretion secretion|compound|END_ENTITY	Hypothalamic distribution of somatostatin mRNA expressing neurones relative to pubertal and adult changes in pulsatile growth_hormone secretion in mice .
2564339	0	somatostatin	120,132	growth_hormone	39,53	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY action|dep|interaction action|nmod|secretion secretion|amod|END_ENTITY	Insulin-like growth factor-I action on growth_hormone secretion and messenger ribonucleic_acid levels : interaction with somatostatin .
2566942	0	somatostatin	241,253	growth_hormone	113,127	somatostatin	growth hormone	6750	2688	Gene	Gene	release|nmod|START_ENTITY act|nmod|release man|appos|act releasing|nmod|man effect|acl|releasing effect|nmod|END_ENTITY	Activation of cholinergic neurotransmission by pyridostigmine reverses the inhibitory effect of hyperglycemia on growth_hormone -LRB- GH -RRB- releasing hormone-induced GH secretion in man : does acute hyperglycemia act through hypothalamic release of somatostatin ?
2571099	0	somatostatin	131,143	growth_hormone	102,116	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|compound|START_ENTITY triggering|dobj|release END_ENTITY|acl|triggering	Physiological role of somatostatin-mediated autofeedback regulation for growth_hormone : importance of growth_hormone in triggering somatostatin release during a trough period of pulsatile growth_hormone release in conscious male rats .
2571099	0	somatostatin	131,143	growth_hormone	188,202	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|compound|START_ENTITY triggering|dobj|release triggering|nmod|period period|nmod|release release|compound|END_ENTITY	Physiological role of somatostatin-mediated autofeedback regulation for growth_hormone : importance of growth_hormone in triggering somatostatin release during a trough period of pulsatile growth_hormone release in conscious male rats .
2571099	0	somatostatin	131,143	growth_hormone	72,86	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|compound|START_ENTITY triggering|dobj|release growth_hormone|acl|triggering importance|nmod|growth_hormone role|dep|importance role|nmod|regulation regulation|nmod|END_ENTITY	Physiological role of somatostatin-mediated autofeedback regulation for growth_hormone : importance of growth_hormone in triggering somatostatin release during a trough period of pulsatile growth_hormone release in conscious male rats .
2575238	0	somatostatin	29,41	growth_hormone	81,95	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	actions|nmod|START_ENTITY actions|nmod|secretion secretion|amod|END_ENTITY	Intrahypothalamic actions of somatostatin and growth_hormone_releasing_factor on growth_hormone secretion .
2860119	0	somatostatin	4,16	growth_hormone	70,84	somatostatin	growth hormone	6750	2688	Gene	Gene	201-995|compound|START_ENTITY induces|nsubj|201-995 induces|dobj|inhibition inhibition|nmod|secretion secretion|amod|END_ENTITY	The somatostatin analog SMS 201-995 induces long-acting inhibition of growth_hormone secretion without rebound hypersecretion in acromegalic patients .
2874559	0	somatostatin	54,66	growth_hormone	125,139	somatostatin	growth hormone	6750	2688	Gene	Gene	caused|nmod|START_ENTITY caused|ccomp|END_ENTITY	Hyperpolarization of the membrane potential caused by somatostatin in dissociated human pituitary_adenoma cells that secrete growth_hormone .
2878009	0	somatostatin	63,75	growth_hormone	22,36	somatostatin	growth hormone	6750	2688	Gene	Gene	SMS_201-995|compound|START_ENTITY END_ENTITY|nmod|SMS_201-995	The response of serum growth_hormone levels to the long-acting somatostatin analog SMS_201-995 in acromegaly .
2885995	0	somatostatin	18,30	growth_hormone	60,74	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	SMS_201-995|compound|START_ENTITY effect|nmod|SMS_201-995 effect|nmod|secretion secretion|compound|END_ENTITY	The effect of the somatostatin analog SMS_201-995 on normal growth_hormone secretion in the rat .
2898964	0	somatostatin	11,23	growth_hormone	37,51	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	antiserum|compound|START_ENTITY antiserum|nmod|levels levels|amod|END_ENTITY	Effects of somatostatin antiserum on growth_hormone levels in rats with periventricular lesions in the anterior hypothalamus .
2903171	0	somatostatin	61,73	growth_hormone	33,47	somatostatin	growth hormone	6750	2688	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Comparison Comparison|nmod|sensitivity sensitivity|nmod|END_ENTITY	Comparison of the sensitivity of growth_hormone secretion to somatostatin in vivo and in vitro in acromegaly .
2903866	0	somatostatin	71,83	growth_hormone	20,34	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY suppressing|dobj|secretion stimulates|advcl|suppressing stimulates|dobj|secretion secretion|amod|END_ENTITY	Arginine stimulates growth_hormone secretion by suppressing endogenous somatostatin secretion .
2906083	0	somatostatin	53,65	growth_hormone	23,37	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	infusion|compound|START_ENTITY release|nmod|infusion release|nmod|END_ENTITY	The rebound release of growth_hormone -LRB- GH -RRB- following somatostatin infusion in rats involves hypothalamic GH-releasing_factor release .
2907415	0	somatostatin	49,61	growth_hormone	25,39	somatostatin	growth hormone	6750	2688	Gene	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	The suppression of blood growth_hormone level by somatostatin infusion in patients with active acromegaly .
2908268	0	somatostatin	137,149	growth_hormone	61,75	somatostatin	growth hormone	6750	2688	Gene	Gene	factor|compound|START_ENTITY effects|nmod|factor studies|dep|effects studies|nmod|expression expression|amod|END_ENTITY	Quantitative in-situ hybridization histochemistry studies on growth_hormone -LRB- GH -RRB- gene expression in acromegalic somatotrophs : effects of somatostatin , GH-releasing factor and cortisol .
391394	0	somatostatin	47,59	growth_hormone	76,90	somatostatin	growth hormone	20604(Tax:10090)	14599(Tax:10090)	Gene	Gene	correlation|nmod|START_ENTITY END_ENTITY|nsubj|correlation	Developmental correlation between hypothalamic somatostatin and hypophysial growth_hormone .
4514982	0	somatostatin	21,33	growth_hormone	99,113	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	structure|nmod|START_ENTITY structure|appos|peptide peptide|acl:relcl|inhibits inhibits|dobj|secretion secretion|nmod|END_ENTITY	Primary structure of somatostatin , a hypothalamic peptide that inhibits the secretion of pituitary growth_hormone .
6113951	0	somatostatin	78,90	growth_hormone	39,53	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	analogs|compound|START_ENTITY secretion|nmod|analogs secretion|nsubj|inhibition inhibition|nmod|END_ENTITY	Potent , highly selective inhibition of growth_hormone secretion by position 4 somatostatin analogs .
6115330	0	somatostatin	24,36	growth_hormone	86,100	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nsubj|effects	Differential effects of somatostatin on the release of bioactive and immunoactive rat growth_hormone in vitro .
6116553	0	somatostatin	48,60	growth_hormone	64,78	somatostatin	growth hormone	6750	2688	Gene	Gene	analogue|nmod|START_ENTITY Effect|nmod|analogue Effect|nmod|hormones hormones|amod|pancreatic pancreatic|dep|END_ENTITY	Effect of a long-acting octapeptide analogue of somatostatin on growth_hormone and pancreatic and gastrointestinal hormones in man .
6141133	0	somatostatin	11,23	growth_hormone	87,101	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	Failure|nmod|START_ENTITY antiserum|nsubj|Failure antiserum|xcomp|reverse reverse|dobj|inhibition inhibition|nmod|secretion secretion|compound|END_ENTITY	Failure of somatostatin antiserum to reverse histamine-induced inhibition of pulsatile growth_hormone secretion .
6143299	0	somatostatin	28,40	growth_hormone	76,90	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|secretion secretion|amod|END_ENTITY	Involvement of hypothalamic somatostatin in glucagon-induced suppression of growth_hormone secretion in conscious rats .
6146235	0	somatostatin	107,119	growth_hormone	21,35	somatostatin	growth hormone	6750	2688	Gene	Gene	administration|nmod|START_ENTITY secretion|nmod|administration secretion|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of foetal growth_hormone -LRB- GH -RRB- and thyrotrophin -LRB- TSH -RRB- secretion after maternal administration of somatostatin .
658886	0	somatostatin	22,34	growth_hormone	56,70	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	-LSB- Role of hypothalamic somatostatin in the regulation of growth_hormone secretion in the rat -LRB- author 's transl -RRB- -RSB- .
667280	0	somatostatin	10,22	growth_hormone	51,65	somatostatin	growth hormone	6750	2688	Gene	Gene	Action|nmod|START_ENTITY Action|nmod|secretion secretion|amod|END_ENTITY	Action of somatostatin , levodopa and pyridoxine on growth_hormone -LRB- GH -RRB- secretion in newborn infants .
7901787	0	somatostatin	193,205	growth_hormone	26,40	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY control|nmod|release evidence|nmod|control potentiates|parataxis|evidence potentiates|dobj|response response|compound|END_ENTITY	Clonidine potentiates the growth_hormone -LRB- GH -RRB- response to GH-releasing hormone in norepinephrine synthesis-inhibited rats : evidence for an alpha-2-adrenergic control of hypothalamic release of somatostatin .
815507	0	somatostatin	45,57	growth_hormone	11,25	somatostatin	growth hormone	6750	2688	Gene	Gene	factor|appos|START_ENTITY factor|compound|END_ENTITY	Effects of growth_hormone inhibiting factor -LRB- somatostatin -RRB- on the release of growth_hormone and prolactin from pituitaries of the domestic fowl in vitro .
815507	0	somatostatin	45,57	growth_hormone	77,91	somatostatin	growth hormone	6750	2688	Gene	Gene	factor|appos|START_ENTITY Effects|nmod|factor Effects|nmod|END_ENTITY	Effects of growth_hormone inhibiting factor -LRB- somatostatin -RRB- on the release of growth_hormone and prolactin from pituitaries of the domestic fowl in vitro .
9200665	0	somatostatin	102,114	growth_hormone	13,27	somatostatin	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY Influence|dep|involvement Influence|nmod|END_ENTITY	Influence of growth_hormone on cysteamine-induced gastro-duodenal_lesions in rats : the involvement of somatostatin .
166088	0	somatostatin	11,23	insulin	55,62	somatostatin	insulin	6750	3630	Gene	Gene	Failure|nmod|START_ENTITY Failure|acl|inhibit inhibit|dobj|secretion secretion|compound|END_ENTITY	Failure of somatostatin to inhibit tolbutamide-induced insulin secretion in patients with insulinomas : a possible diagnostic tool .
1685991	0	somatostatin	96,108	insulin	14,21	somatostatin	insulin	6750	3630	Gene	Gene	infusion|nmod|START_ENTITY studies|nmod|infusion effect|dep|studies effect|nmod|suppression suppression|compound|END_ENTITY	The effect of insulin suppression on postprandial nutrient metabolism : studies with infusion of somatostatin and insulin .
437378	1	somatostatin	59,71	insulin	94,101	somatostatin	insulin	6750	3630	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of somatostatin and somatostatin plus insulin .
6132675	0	somatostatin	20,32	insulin	50,57	somatostatin	insulin	6750	3630	Gene	Gene	role|nmod|START_ENTITY role|nmod|depression depression|nmod|levels levels|compound|END_ENTITY	A possible role for somatostatin in depression of insulin and glucagon levels during hemorrhage .
8764190	0	somatostatin	11,23	insulin	37,44	somatostatin	insulin	403993(Tax:9615)	483665(Tax:9615)	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effects of somatostatin on pulsatile insulin secretion : elective inhibition of insulin burst mass .
8764190	0	somatostatin	11,23	insulin	79,86	somatostatin	insulin	403993(Tax:9615)	483665(Tax:9615)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|inhibition inhibition|nmod|mass mass|compound|END_ENTITY	Effects of somatostatin on pulsatile insulin secretion : elective inhibition of insulin burst mass .
908478	0	somatostatin	23,35	insulin	61,68	somatostatin	insulin	6750	3630	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|nmod|ajunct ajunct|nmod|END_ENTITY	Clinical evaluation of somatostatin as a potential ajunct to insulin in the management of diabetes_mellitus .
934480	0	somatostatin	55,67	insulin	29,36	somatostatin	insulin	6750	3630	Gene	Gene	induced|nmod|START_ENTITY levels|acl|induced levels|compound|END_ENTITY	-LSB- Changes in blood sugar , and insulin levels induced by somatostatin in normal , diabetic and acromegalic subjects -RSB- .
7903432	0	somatostatin	49,61	interleukin-2	17,30	somatostatin	interleukin-2	6750	3558	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	The influence of interleukin-2 on the release of somatostatin and growth hormone-releasing hormone by mediobasal_hypothalamus .
2872717	1	somatostatin	149,161	motilin	93,100	somatostatin	motilin	6750	4295	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	A study of plasma motilin and somatostatin during intravenous infusion of somatostatin , secretin , cholecystokinin , and gastric inhibitory polypeptide .
105871	0	somatostatin	10,22	parathyroid_hormone	26,45	somatostatin	parathyroid hormone	6750	5741	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of somatostatin on parathyroid_hormone and calcitonin secretion .
6109693	0	somatostatin	18,30	parathyroid_hormone	45,64	somatostatin	parathyroid hormone	280932(Tax:9913)	280903(Tax:9913)	Gene	Gene	Mode|nmod|START_ENTITY Mode|acl|inhibiting inhibiting|dobj|secretion secretion|amod|END_ENTITY	Mode of action of somatostatin in inhibiting parathyroid_hormone secretion .
6126979	0	somatostatin	11,23	parathyroid_hormone	27,46	somatostatin	parathyroid hormone	280932(Tax:9913)	280903(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|amod|END_ENTITY	Effects of somatostatin on parathyroid_hormone levels and on responses of parathyroid_hormone to beta-adrenergic agonists and hypocalcaemia .
675202	0	somatostatin	11,23	secretin	53,61	somatostatin	secretin	403993(Tax:9615)	483407(Tax:9615)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	-LSB- Effect of somatostatin on the endogenous release of secretin and pancreatic polypeptide in the dog -RSB- .
10194497	0	somatostatin	11,23	somatostatin	68,80	somatostatin	somatostatin	6750	6750	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of somatostatin , somatostatin analogs , and endothelial cell somatostatin gene transfer on smooth_muscle_cell proliferation in vitro .
10194497	0	somatostatin	68,80	somatostatin	11,23	somatostatin	somatostatin	6750	6750	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of somatostatin , somatostatin analogs , and endothelial cell somatostatin gene transfer on smooth_muscle_cell proliferation in vitro .
355782	0	somatostatin	13,25	somatostatin	99,111	somatostatin	somatostatin	24797(Tax:10116)	24797(Tax:10116)	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|END_ENTITY	Secretion of somatostatin by rat islets of Langerhans and gastric mucosa and a role for pancreatic somatostatin in the regulation of glucagon release .
355782	0	somatostatin	99,111	somatostatin	13,25	somatostatin	somatostatin	24797(Tax:10116)	24797(Tax:10116)	Gene	Gene	Secretion|nmod|START_ENTITY Secretion|nmod|END_ENTITY	Secretion of somatostatin by rat islets of Langerhans and gastric mucosa and a role for pancreatic somatostatin in the regulation of glucagon release .
6155261	0	somatostatin	60,72	substance_P	11,22	somatostatin	substance P	6750	6863	Gene	Gene	release|nmod|START_ENTITY Effects|nmod|release Effects|nmod|peptides peptides|compound|END_ENTITY	Effects of substance_P and other peptides on the release of somatostatin , insulin , and glucagon in vitro .
9209609	0	somatostatin	7,19	thyrotropin-releasing_hormone	87,116	somatostatin	thyrotropin-releasing hormone	6750	7200	Gene	Gene	correlates|nsubj|START_ENTITY correlates|nmod|END_ENTITY	Plasma somatostatin correlates with blunted thyrotropin secretion after stimulation by thyrotropin-releasing_hormone in critical_illness .
6108897	0	somatostatin	11,23	vasopressin	118,129	somatostatin	vasopressin	6750	551	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis_of_the_liver : comparison with vasopressin .
14614908	0	somatostatin-14	82,97	PC2	26,29	somatostatin-14	PC2	6750	5126	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer 's _ disease .
9576606	0	somatostatin-14	41,56	somatostatin-14	74,89	somatostatin-14	somatostatin-14	6750	6750	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effects of the two somatostatin variants somatostatin-14 and -LSB- Pro2 , Met13 -RSB- somatostatin-14 on receptor binding , adenylyl cyclase activity and growth_hormone release from the frog pituitary .
9576606	0	somatostatin-14	74,89	somatostatin-14	41,56	somatostatin-14	somatostatin-14	6750	6750	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Effects of the two somatostatin variants somatostatin-14 and -LSB- Pro2 , Met13 -RSB- somatostatin-14 on receptor binding , adenylyl cyclase activity and growth_hormone release from the frog pituitary .
1356334	0	somatostatin_and_GH-releasing_factor	73,109	growth_hormone	113,127	somatostatin and GH-releasing factor	growth hormone	6750	2688	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effectors of ATP-sensitive K + channels inhibit the regulatory effects of somatostatin_and_GH-releasing_factor on growth_hormone secretion .
2881773	0	somatostatin_and_GH-releasing_factor	75,111	growth_hormone	33,47	somatostatin and GH-releasing factor	growth hormone	24797(Tax:10116)	81668(Tax:10116)	Gene	Gene	roles|nmod|START_ENTITY Mechanisms|dep|roles Mechanisms|nmod|suppression suppression|amod|END_ENTITY	Mechanisms of calcitonin-induced growth_hormone -LRB- GH -RRB- suppression : roles of somatostatin_and_GH-releasing_factor .
23112170	0	somatostatin_receptor-5	46,69	ghrelin_receptor	16,32	somatostatin receptor-5	ghrelin receptor	6755	2693	Gene	Gene	signaling|advcl|START_ENTITY END_ENTITY|acl|signaling	Modification of ghrelin_receptor signaling by somatostatin_receptor-5 regulates insulin release .
10866997	0	somatostatin_receptor_1	52,75	Tst-1	36,41	somatostatin receptor 1	Tst-1	6751	100526790	Gene	Gene	expression|amod|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	The POU domain transcription factor Tst-1 activates somatostatin_receptor_1 gene expression in pancreatic beta - cells .
9681962	0	somatostatin_receptor_1	20,43	sst1	45,49	somatostatin receptor 1	sst1	25033(Tax:10116)	25033(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	The localization of somatostatin_receptor_1 -LRB- sst1 -RRB- immunoreactivity in the rat brain using an N-terminal specific antibody .
10604740	0	somatostatin_receptor_2	125,148	SSTR2	149,154	somatostatin receptor 2	SSTR2	6752	6752	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma , but does not involve mutations in the somatostatin_receptor_2 -LRB- SSTR2 -RRB- gene at 17q24 .
8961277	0	somatostatin_receptor_3	96,119	p53	41,44	somatostatin receptor 3	p53	6753	7157	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Subtype-selective induction of wild-type p53 and apoptosis , but not cell cycle arrest , by human somatostatin_receptor_3 .
12192619	0	somatostatin_receptor_5	27,50	SSTR5	52,57	somatostatin receptor 5	SSTR5	6755	6755	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel polymorphisms in the somatostatin_receptor_5 -LRB- SSTR5 -RRB- gene associated with bipolar_affective_disorder .
12898583	0	somatostatin_receptor_5	55,78	SSTR5	80,85	somatostatin receptor 5	SSTR5	6755	6755	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of transmission of novel polymorphisms in the somatostatin_receptor_5 -LRB- SSTR5 -RRB- gene in patients with autism .
21693197	0	somatostatin_receptor_subtype_2	49,80	SSTR_2	82,88	somatostatin receptor subtype 2	SSTR 2	100499615	100499615	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Isolation , characterization , and distribution of somatostatin_receptor_subtype_2 -LRB- SSTR_2 -RRB- mRNA in rainbow_trout -LRB- Oncorhynchus_mykiss -RRB- , and regulation of its expression by glucose .
10373412	0	somatostatin_receptor_subtype_2	41,72	cortactin-binding_protein_1	78,105	somatostatin receptor subtype 2	cortactin-binding protein 1	54305(Tax:10116)	171093(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Agonist-dependent interaction of the rat somatostatin_receptor_subtype_2 with cortactin-binding_protein_1 .
26036598	0	somatostatin_receptor_subtype_2	14,45	miR-185	114,121	somatostatin receptor subtype 2	miR-185	54305(Tax:10116)	100314243(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of somatostatin_receptor_subtype_2 in growth_hormone-secreting pituitary_adenoma and the regulation of miR-185 .
12110536	0	somatostatin_receptor_subtype_5	46,77	GLP-1	26,31	somatostatin receptor subtype 5	GLP-1	25354(Tax:10116)	24952(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Somatostatin-28 regulates GLP-1 secretion via somatostatin_receptor_subtype_5 in rat intestinal cultures .
22669743	0	somatostatin_receptor_subtype_5	61,92	pancreatic_and_duodenal_homeobox-1	23,57	somatostatin receptor subtype 5	pancreatic and duodenal homeobox-1	6755	3651	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Negative regulation of pancreatic_and_duodenal_homeobox-1 by somatostatin_receptor_subtype_5 .
18289730	0	somatostatin_receptor_subtypes_2_and_5	55,93	Urotensin_II	0,12	somatostatin receptor subtypes 2 and 5	Urotensin II	6755	10911	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Urotensin_II and urotensin_II-related_peptide activate somatostatin_receptor_subtypes_2_and_5 .
10446977	0	somatostatin_receptor_type_2	27,55	sst_2	57,62	somatostatin receptor type 2	sst 2	20606(Tax:10090)	20606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differential regulation of somatostatin_receptor_type_2 -LRB- sst_2 -RRB- expression in AR4-2J tumor cells implanted into mice during octreotide treatment .
14680841	0	somite_Maf_1	35,47	MafA	6,10	somite Maf 1	MafA	100000492(Tax:7955)	114467(Tax:7955)	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Mouse MafA , homologue of zebrafish somite_Maf_1 , contributes to the specific transcriptional activity through the insulin promoter .
25756958	0	sonic_hedgehog	28,42	SHH	44,47	sonic hedgehog	SHH	6469	6469	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Proteomic analysis of human sonic_hedgehog -LRB- SHH -RRB- medulloblastoma stem-like cells .
25756958	0	sonic_hedgehog	28,42	SHH	44,47	sonic hedgehog	SHH	6469	6469	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Proteomic analysis of human sonic_hedgehog -LRB- SHH -RRB- medulloblastoma stem-like cells .
12889063	0	sonic_hedgehog	40,54	neurogenin-1	13,25	sonic hedgehog	neurogenin-1	6469	4762	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of neurogenin-1 expression by sonic_hedgehog : Its role in development of trigeminal sensory neurons .
15272389	0	sonic_hedgehog	57,71	shh	73,76	sonic hedgehog	shh	30269(Tax:7955)	30269(Tax:7955)	Gene	Gene	START_ENTITY|dobj|expression expression|appos|END_ENTITY	Scale development in fish : a review , with description of sonic_hedgehog _ -LRB- shh -RRB- expression in the zebrafish -LRB- Danio_rerio -RRB- .
11532984	0	sorbin_and_SH3-domain-containing-1	32,66	SORBS1	68,74	sorbin and SH3-domain-containing-1	SORBS1	10580	10580	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular scanning of the human sorbin_and_SH3-domain-containing-1 -LRB- SORBS1 -RRB- gene : positive association of the T228A polymorphism with obesity and type 2 diabetes .
18394047	0	sorbin_and_SH3-domain-containing-1	20,54	SORBS1	56,62	sorbin and SH3-domain-containing-1	SORBS1	10580	10580	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the sorbin_and_SH3-domain-containing-1 -LRB- SORBS1 -RRB- gene and the risk of brain_infarction in the Japanese population : the Fukuoka Stroke Registry and the Hisayama study .
11374898	0	sorbin_and_SH3_domain_containing_1	52,86	SORBS1	88,94	sorbin and SH3 domain containing 1	SORBS1	10580	10580	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning , mapping , and characterization of the human sorbin_and_SH3_domain_containing_1 -LRB- SORBS1 -RRB- gene : a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B .
7782086	0	sorbitol_dehydrogenase	37,59	SORD	66,70	sorbitol dehydrogenase	SORD	6652	6652	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structural organization of the human sorbitol_dehydrogenase gene -LRB- SORD -RRB- .
10188938	0	sorcin	116,122	N-methyl-D-aspartate_receptor	0,29	sorcin	N-methyl-D-aspartate receptor	683667(Tax:10116)	24408(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|dep|localization	N-methyl-D-aspartate_receptor 1 in the caudate-putamen nucleus : ultrastructural localization and co-expression with sorcin , a 22,000 mol .
18938222	0	sortilin-1	27,37	SORL1	39,44	sortilin-1	SORL1	6272	6272	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Allelic mRNA expression of sortilin-1 -LRB- SORL1 -RRB- mRNA in Alzheimer 's autopsy brain tissues .
23477787	0	sorting_nexin_1	21,36	CLASP	0,5	sorting nexin 1	CLASP	830501(Tax:3702)	816539(Tax:3702)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CLASP interacts with sorting_nexin_1 to link microtubules and auxin transport via PIN2 recycling in Arabidopsis_thaliana .
11110793	0	sorting_nexin_1	19,34	Hrs	0,3	sorting nexin 1	Hrs	6642	9146	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Hrs interacts with sorting_nexin_1 and regulates degradation of epidermal_growth_factor_receptor .
17077144	0	sorting_nexin_13	26,42	RGS-PX1	18,25	sorting nexin 13	RGS-PX1	217463(Tax:10090)	217463(Tax:10090)	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	Essential role of RGS-PX1 / sorting_nexin_13 in mouse development and regulation of endocytosis dynamics .
25059659	0	sorting_nexin_17	39,55	KRIT1	127,132	sorting nexin 17	KRIT1	9784	889	Gene	Gene	binding|nmod|START_ENTITY Krev_interaction_trapped_1|amod|binding Krev_interaction_trapped_1|appos|END_ENTITY	Structural determinants for binding of sorting_nexin_17 -LRB- SNX17 -RRB- to the cytoplasmic_adaptor protein Krev_interaction_trapped_1 -LRB- KRIT1 -RRB- .
25059659	0	sorting_nexin_17	39,55	Krev_interaction_trapped_1	99,125	sorting nexin 17	Krev interaction trapped 1	9784	889	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Structural determinants for binding of sorting_nexin_17 -LRB- SNX17 -RRB- to the cytoplasmic_adaptor protein Krev_interaction_trapped_1 -LRB- KRIT1 -RRB- .
25183008	0	sorting_nexin_2	85,100	Biogenesis_of_lysosome-related_organelles_complex-1_subunit_1	0,61	sorting nexin 2	Biogenesis of lysosome-related organelles complex-1 subunit 1	67804(Tax:10090)	14533(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Biogenesis_of_lysosome-related_organelles_complex-1_subunit_1 -LRB- BLOS1 -RRB- interacts with sorting_nexin_2 and the endosomal sorting complex required for transport-I -LRB- ESCRT-I -RRB- component TSG101 to mediate the sorting of epidermal_growth_factor_receptor into endosomal compartments .
15133132	0	sorting_nexin_5	87,102	CHC22	17,22	sorting nexin 5	CHC22	27131	8218	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Clathrin isoform CHC22 , a component of neuromuscular and myotendinous junctions , binds sorting_nexin_5 and has increased expression during myogenesis and muscle regeneration .
20354142	0	sorting_nexin_6	28,43	APP	86,89	sorting nexin 6	APP	58533	351	Gene	Gene	identification|nmod|START_ENTITY END_ENTITY|nsubj|identification	Proteomic identification of sorting_nexin_6 as a negative regulator of BACE1-mediated APP processing .
16730713	0	sorting_nexin_6	94,109	translationally_controlled_tumor_protein	50,90	sorting nexin 6	translationally controlled tumor protein	58533	7178	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Na,K-ATPase-suppressive activity of translationally_controlled_tumor_protein by sorting_nexin_6 .
24362679	0	sorting_nexin_8	27,42	SNX8	44,48	sorting nexin 8	SNX8	29886	29886	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of neuronal sorting_nexin_8 -LRB- SNX8 -RRB- exacerbates abnormal cholesterol levels .
20491914	0	sorting_nexin_9	39,54	Itch	24,28	sorting nexin 9	Itch	51429	83737	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	The E3 ubiquitin ligase Itch regulates sorting_nexin_9 through an unconventional substrate recognition domain .
20836130	0	sox10	17,22	prdm1a	0,6	sox10	prdm1a	140616(Tax:7955)	323473(Tax:7955)	Gene	Gene	Regulates|dobj|START_ENTITY Regulates|nsubj|END_ENTITY	prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard_sensory_neurons .
10559493	0	sox11A	33,39	sox11B	41,47	sox11A	sox11B	30602(Tax:7955)	30603(Tax:7955)	Gene	Gene	zebrafish|nummod|START_ENTITY zebrafish|nummod|END_ENTITY	Expression patterns of zebrafish sox11A , sox11B and sox21 .
10559493	0	sox11B	41,47	sox11A	33,39	sox11B	sox11A	30603(Tax:7955)	30602(Tax:7955)	Gene	Gene	zebrafish|nummod|START_ENTITY zebrafish|nummod|END_ENTITY	Expression patterns of zebrafish sox11A , sox11B and sox21 .
21028992	0	sox2	14,18	Akt	0,3	sox2	Akt	6657	207	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Akt increases sox2 expression in adult hippocampal neural progenitor cells , but increased sox2 does not promote proliferation .
18927476	0	sox2	29,33	Gli2	0,4	sox2	Gli2	20674(Tax:10090)	14633(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells .
25339068	0	sox2	67,71	Slug	0,4	sox2	Slug	6657	6591	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Slug promotes hepatocellular_cancer cell progression by increasing sox2 and nanog expression .
18992330	0	sox2	23,27	Sox3	8,12	sox2	Sox3	398000(Tax:8355)	399335(Tax:8355)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives .
24662752	0	sox6	14,18	cyclin_dependent_kinase_5	22,47	sox6	cyclin dependent kinase 5	20679(Tax:10090)	12568(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of sox6 by cyclin_dependent_kinase_5 in brain .
27058905	0	sox7	80,84	MicroRNA-452	0,12	sox7	MicroRNA-452	83595	574412	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	MicroRNA-452 promotes stem-like cells of hepatocellular_carcinoma by inhibiting sox7 involving wnt/b-catenin signaling pathway .
17534446	0	sp1	57,60	AKT	100,103	sp1	AKT	6667	207	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Membrane-type_1_matrix_metalloproteinase is regulated by sp1 through the differential activation of AKT , JNK , and ERK pathways in human prostate_tumor cells .
10552902	0	sp1	41,44	Thrombin	0,8	sp1	Thrombin	6667	2147	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Thrombin activates transcription factors sp1 , NF-kappaB , and CREB : importance of the use of phosphatase inhibitors during nuclear protein extraction for the assessment of transcription factor DNA-binding activities .
15372625	0	sp1	99,102	Transforming_growth_factor_beta	0,31	sp1	Transforming growth factor beta	6667	7040	Gene	Gene	factors|amod|START_ENTITY mediated|nmod|factors mediated|nsubj|stimulation stimulation|compound|END_ENTITY	Transforming_growth_factor_beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors .
9693142	0	spadetail	59,68	paraxial_protocadherin	10,32	spadetail	paraxial protocadherin	30264(Tax:7955)	30456(Tax:7955)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Zebrafish paraxial_protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm .
19580544	0	spartin	11,18	AIP4	116,120	spartin	AIP4	23111	83737	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	Endogenous spartin -LRB- SPG20 -RRB- is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5 .
16036216	0	spartin	36,43	Eps15	59,64	spartin	Eps15	23111	2060	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The Troyer_syndrome -LRB- SPG20 -RRB- protein spartin interacts with Eps15 .
20719964	0	spartin	14,21	Ist1	69,73	spartin	Ist1	23111	9798	Gene	Gene	recruited|nsubjpass|START_ENTITY recruited|nmod|END_ENTITY	SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis .
18997780	0	spastin	42,49	CHMP1B	75,81	spastin	CHMP1B	6683	57132	Gene	Gene	targeting|nmod|START_ENTITY targeting|nmod|END_ENTITY	Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B .
20200447	0	spastin	46,53	REEP1	39,44	spastin	REEP1	362700(Tax:10116)	362384(Tax:10116)	Gene	Gene	proteins|nummod|START_ENTITY proteins|nummod|END_ENTITY	Hereditary spastic_paraplegia proteins REEP1 , spastin , and atlastin-1 coordinate microtubule interactions with the tubular ER network .
11723204	0	spastin	88,95	SPG4	97,101	spastin	SPG4	6683	6683	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A large family with hereditary_spastic_paraparesis due to a frame shift mutation of the spastin -LRB- SPG4 -RRB- gene : association with multiple_sclerosis in two affected siblings and epilepsy in other affected family members .
24729451	0	special_AT-rich_binding_protein_1	24,57	SATB1	59,64	special AT-rich binding protein 1	SATB1	20230(Tax:10090)	20230(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Multiple effects of the special_AT-rich_binding_protein_1 -LRB- SATB1 -RRB- in colon_carcinoma .
6973005	0	specific_beta_1-glycoprotein	32,60	SP1	62,65	specific beta 1-glycoprotein	SP1	6667	6667	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Circulating levels of pregnancy specific_beta_1-glycoprotein -LRB- SP1 -RRB- in normal pregnancy and in intrauterine_growth_retardation .
16964286	0	specificity_protein-1	79,100	KiSS-1	30,36	specificity protein-1	KiSS-1	6667	3814	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity_protein-1 and its coactivator DRIP-130 .
16269451	0	specificity_protein-1	128,149	hormone-sensitive_lipase	80,104	specificity protein-1	hormone-sensitive lipase	6667	3991	Gene	Gene	involvement|nmod|START_ENTITY END_ENTITY|nmod|involvement	Peroxisome_proliferator-activated_receptor-gamma transcriptionally up-regulates hormone-sensitive_lipase via the involvement of specificity_protein-1 .
19049975	0	specificity_protein_1	110,131	FoxO1	0,5	specificity protein 1	FoxO1	6667	2308	Gene	Gene	blocking|nmod|START_ENTITY inhibits|advcl|blocking inhibits|nsubj|END_ENTITY	FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity_protein_1 .
24821721	0	specificity_protein_1	126,147	SIGIRR	92,98	specificity protein 1	SIGIRR	6667	59307	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
21618058	0	specificity_protein_1	80,101	SP1	103,106	specificity protein 1	SP1	24790(Tax:10116)	24790(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Rat pancreatic level of cystathionine y-lyase is regulated by glucose level via specificity_protein_1 -LRB- SP1 -RRB- phosphorylation .
15013634	0	specificity_protein_1	134,155	Sp1	157,160	specificity protein 1	Sp1	6667	6667	Gene	Gene	factor|amod|START_ENTITY factor|appos|END_ENTITY	Transcriptional control of the human pregnancy-specific_glycoprotein_5 gene is dependent on two GT-boxes recognized by the ubiquitous specificity_protein_1 -LRB- Sp1 -RRB- transcription factor .
25428991	0	specificity_protein_1	23,44	midkine	111,118	specificity protein 1	midkine	6667	4192	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	Transcriptional factor specificity_protein_1 -LRB- SP1 -RRB- promotes the proliferation of glioma cells by up-regulating midkine -LRB- MDK -RRB- .
24821721	0	specificity_protein_1	126,147	p38	190,193	specificity protein 1	p38	6667	1432	Gene	Gene	START_ENTITY|dep|pathway pathway|amod|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
24821721	0	specificity_protein_1	126,147	single_immunoglobulin_interleukin-1_receptor-related_molecule	29,90	specificity protein 1	single immunoglobulin interleukin-1 receptor-related molecule	6667	59307	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Lipopolysaccharide decreases single_immunoglobulin_interleukin-1_receptor-related_molecule -LRB- SIGIRR -RRB- expression by suppressing specificity_protein_1 -LRB- Sp1 -RRB- via the Toll-like_receptor_4 -LRB- TLR4 -RRB- - p38 pathway in monocytes and neutrophils .
18997279	0	speckle-type_POZ_protein	18,42	SPOP	44,48	speckle-type POZ protein	SPOP	8405	8405	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	BTB/POZ domain of speckle-type_POZ_protein -LRB- SPOP -RRB- confers proapoptotic function in HeLa cells .
17196711	0	spectrin_alpha_II_chain	55,78	dihydropyrimidinase-related_protein_2	16,53	spectrin alpha II chain	dihydropyrimidinase-related protein 2	64159(Tax:10116)	66027(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Upregulation of dihydropyrimidinase-related_protein_2 , spectrin_alpha_II_chain , heat_shock cognate protein 70 pseudogene 1 and tropomodulin_2 after focal cerebral_ischemia in rats -- a proteomics approach .
16643671	0	sperm_associated_antigen_11	65,92	SPAG11	94,100	sperm associated antigen 11	SPAG11	246305(Tax:10116)	246305(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Identification , cloning and functional characterization of novel sperm_associated_antigen_11 -LRB- SPAG11 -RRB- isoforms in the rat .
24424245	0	sperm_associated_antigen_5	58,84	OSBP-related_protein_8	0,22	sperm associated antigen 5	OSBP-related protein 8	10615	114882	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	OSBP-related_protein_8 -LRB- ORP8 -RRB- interacts with Homo_sapiens sperm_associated_antigen_5 -LRB- SPAG5 -RRB- and mediates oxysterol interference of HepG2 cell cycle .
19548270	0	sperm_associated_antigen_8	50,76	SPAG8	78,83	sperm associated antigen 8	SPAG8	26206	26206	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Regulation of the G2/M phase of the cell cycle by sperm_associated_antigen_8 -LRB- SPAG8 -RRB- protein .
11940662	0	sperm_mitochondrion-associated_cysteine-rich_protein	56,108	Smcp	110,114	sperm mitochondrion-associated cysteine-rich protein	Smcp	17235(Tax:10090)	17235(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Asthenozoospermia in mice with targeted deletion of the sperm_mitochondrion-associated_cysteine-rich_protein -LRB- Smcp -RRB- gene .
15257753	0	sperm_protein_17	15,31	A-kinase_anchoring_protein_3	37,65	sperm protein 17	A-kinase anchoring protein 3	53340	10566	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of sperm_protein_17 with A-kinase_anchoring_protein_3 in flagella .
14712480	0	sperm_protein_17	14,30	Sp17	32,36	sperm protein 17	Sp17	53340	53340	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of sperm_protein_17 -LRB- Sp17 -RRB- in ovarian_cancer .
12393185	0	sperm_protein_17	45,61	Sp17-1	68,74	sperm protein 17	Sp17-1	53340	53340	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of an intron-containing sperm_protein_17 gene -LRB- Sp17-1 -RRB- and an intronless pseudogene -LRB- Sp17-2 -RRB- in humans : a new model .
12393185	0	sperm_protein_17	45,61	Sp17-2	106,112	sperm protein 17	Sp17-2	53340	171424	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic organization of an intron-containing sperm_protein_17 gene -LRB- Sp17-1 -RRB- and an intronless pseudogene -LRB- Sp17-2 -RRB- in humans : a new model .
15704685	0	sperm_protein_22	28,44	SP22	46,50	sperm protein 22	SP22	10935	10935	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Advances in the studies of sperm_protein_22 -LRB- SP22 -RRB- -RSB- .
17609507	0	sperm_protein_22	14,30	SP22	32,36	sperm protein 22	SP22	117287(Tax:10116)	117287(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of sperm_protein_22 -LRB- SP22 -RRB- in the rat ovary during different reproductive states .
12771232	0	spermatogenesis_associated_6	73,101	Spata6	108,114	spermatogenesis associated 6	Spata6	67946(Tax:10090)	67946(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization , expression pattern and chromosomal localization of the spermatogenesis_associated_6 gene -LRB- Spata6 -RRB- .
15226296	0	spermatogenic_zip_protein	22,47	Spz1	48,52	spermatogenic zip protein	Spz1	79401(Tax:10090)	79401(Tax:10090)	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification of the spermatogenic_zip_protein Spz1 as a putative protein phosphatase-1 -LRB- PP1 -RRB- regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis .
9073064	0	spermidine_synthase	109,128	SPE3	98,102	spermidine synthase	SPE3	856182(Tax:4932)	856182(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Spermidine biosynthesis in Saccharomyces cerevisae : polyamine requirement of a null mutant of the SPE3 gene -LRB- spermidine_synthase -RRB- .
3142228	1	spermidine_synthase	81,100	diamine_oxidase	108,123	spermidine synthase	diamine oxidase	6723	26	Gene	Gene	START_ENTITY|nmod|assay assay|amod|END_ENTITY	Part I : Interference of spermidine_synthase on the diamine_oxidase activity assay using putrescine as substrate .
9573363	0	spermine_synthase	99,116	SPE4	88,92	spermine synthase	SPE4	850838(Tax:4932)	850838(Tax:4932)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Spermine is not essential for growth of Saccharomyces_cerevisiae : identification of the SPE4 gene -LRB- spermine_synthase -RRB- and characterization of a spe4 deletion mutant .
3771578	0	sphingolipid_activator_protein-2	28,60	SAP-2	62,67	sphingolipid activator protein-2	SAP-2	2004	2004	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis and processing of sphingolipid_activator_protein-2 -LRB- SAP-2 -RRB- in cultured human fibroblasts .
2109697	0	sphingolipid_activator_protein_2	35,67	SAP-2	69,74	sphingolipid activator protein 2	SAP-2	2004	2004	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of sphingolipid_activator_protein_2 -LRB- SAP-2 -RRB- in normal and SAP-deficient fibroblasts .
12607113	0	sphingomyelin_phosphodiesterase-1	31,64	SMPD1	66,71	sphingomyelin phosphodiesterase-1	SMPD1	6609	6609	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Compound heterozygosity at the sphingomyelin_phosphodiesterase-1 -LRB- SMPD1 -RRB- gene is associated with low HDL cholesterol .
23618813	0	sphingomyelin_phosphodiesterase_1	16,49	SMPD1	56,61	sphingomyelin phosphodiesterase 1	SMPD1	6609	6609	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the sphingomyelin_phosphodiesterase_1 gene -LRB- SMPD1 -RRB- in Turkish Niemann-Pick_disease patients : mutation profile and description of a novel mutation .
16025116	0	sphingomyelin_phosphodiesterase_3	32,65	Smpd3	67,72	sphingomyelin phosphodiesterase 3	Smpd3	58994(Tax:10090)	58994(Tax:10090)	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	A deletion in the gene encoding sphingomyelin_phosphodiesterase_3 -LRB- Smpd3 -RRB- results in osteogenesis and dentinogenesis imperfecta in the mouse .
17616479	0	sphingomyelin_synthase	14,36	SMS	38,41	sphingomyelin synthase	SMS	6611	6611	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of sphingomyelin_synthase -LRB- SMS -RRB- affects intracellular sphingomyelin accumulation and plasma membrane lipid organization .
18694848	0	sphingomyelin_synthase	27,49	SMS	51,54	sphingomyelin synthase	SMS	6611	6611	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	The domain responsible for sphingomyelin_synthase -LRB- SMS -RRB- activity .
25831888	0	sphingomyelin_synthase_1	15,39	SGMS1	41,46	sphingomyelin synthase 1	SGMS1	259230	259230	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	-LSB- Expression of sphingomyelin_synthase_1 -LRB- SGMS1 -RRB- gene varies in human lung and oesophagus_cancer -RSB- .
20068174	0	sphingosine-1-phosphate	43,66	S1P	0,3	sphingosine-1-phosphate	S1P	13609(Tax:10090)	13609(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	S1P -LRB- 2 -RRB- , the G protein-coupled receptor for sphingosine-1-phosphate , negatively regulates tumor angiogenesis and tumor growth in vivo in mice .
16682185	0	sphingosine-1-phosphate_1	40,65	S1P1	67,71	sphingosine-1-phosphate 1	S1P1	1901	1901	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Highly selective and potent agonists of sphingosine-1-phosphate_1 -LRB- S1P1 -RRB- receptor .
23723450	0	sphingosine-1-phosphate_receptor_2	17,51	S1PR2	53,58	sphingosine-1-phosphate receptor 2	S1PR2	9294	9294	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of sphingosine-1-phosphate_receptor_2 -LRB- S1PR2 -RRB- in acute vascular_inflammation .
18922980	0	sphingosine-1-phosphate_receptor_2	99,133	connective_tissue_growth_factor	31,62	sphingosine-1-phosphate receptor 2	connective tissue growth factor	9294	1490	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|compound|END_ENTITY	Induction of antiproliferative connective_tissue_growth_factor expression in Wilms ' _ tumor cells by sphingosine-1-phosphate_receptor_2 .
21256191	0	sphingosine_1-phosphate	49,72	ERK1/2	20,26	sphingosine 1-phosphate	ERK1/2	13609(Tax:10090)	26417;26413	Gene	Gene	induced|nmod|START_ENTITY activation|acl|induced activation|nummod|END_ENTITY	Redox regulation of ERK1/2 activation induced by sphingosine_1-phosphate in fibroblasts : involvement of NADPH oxidase and platelet-derived growth factor receptor .
24131465	0	sphingosine_1-phosphate	75,98	proteinase_activated_receptor-2	15,46	sphingosine 1-phosphate	proteinase activated receptor-2	13609(Tax:10090)	14063(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of proteinase_activated_receptor-2 in the vascular response to sphingosine_1-phosphate .
24468113	0	sphingosine_1-phosphate_lyase	42,71	sphingosine_kinase-1	8,28	sphingosine 1-phosphate lyase	sphingosine kinase-1	8879	8877	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Reduced sphingosine_kinase-1 and enhanced sphingosine_1-phosphate_lyase expression demonstrate deregulated sphingosine_1-phosphate signaling in Alzheimer 's _ disease .
25890801	0	sphingosine_1-phosphate_receptor_1	42,76	S1P1	78,82	sphingosine 1-phosphate receptor 1	S1P1	29733(Tax:10116)	29733(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of heterocyclic_sulfonamides as sphingosine_1-phosphate_receptor_1 -LRB- S1P1 -RRB- antagonists .
25601519	0	sphingosine_1-phosphate_receptor_5	106,140	CTGF	80,84	sphingosine 1-phosphate receptor 5	CTGF	53637	1490	Gene	Gene	requires|dobj|START_ENTITY connective_tissue_growth_factor|acl:relcl|requires connective_tissue_growth_factor|appos|END_ENTITY	Transforming_growth_factor_b2 -LRB- TGF-b2 -RRB- - induced connective_tissue_growth_factor -LRB- CTGF -RRB- expression requires sphingosine_1-phosphate_receptor_5 -LRB- S1P5 -RRB- in human mesangial cells .
25601519	0	sphingosine_1-phosphate_receptor_5	106,140	connective_tissue_growth_factor	47,78	sphingosine 1-phosphate receptor 5	connective tissue growth factor	53637	1490	Gene	Gene	requires|dobj|START_ENTITY END_ENTITY|acl:relcl|requires	Transforming_growth_factor_b2 -LRB- TGF-b2 -RRB- - induced connective_tissue_growth_factor -LRB- CTGF -RRB- expression requires sphingosine_1-phosphate_receptor_5 -LRB- S1P5 -RRB- in human mesangial cells .
26130058	0	sphingosine_1_phosphate_receptor-1	17,51	S1P1	53,57	sphingosine 1 phosphate receptor-1	S1P1	1901	1901	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Dysregulation of sphingosine_1_phosphate_receptor-1 -LRB- S1P1 -RRB- signaling and regulatory lymphocyte-dependent immunosuppression in a model of post-fingolimod MS rebound .
17719579	0	sphingosine_kinase	78,96	Tumor_necrosis_factor-alpha	0,27	sphingosine kinase	Tumor necrosis factor-alpha	8877	7124	Gene	Gene	myoblasts|nmod|START_ENTITY action|nmod|myoblasts action|amod|END_ENTITY	Tumor_necrosis_factor-alpha exerts pro-myogenic action in C2C12 myoblasts via sphingosine_kinase / S1P2 signaling .
16636149	0	sphingosine_kinase-1	89,109	EGFR	24,28	sphingosine kinase-1	EGFR	8877	1956	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Estrogen transactivates EGFR via the sphingosine_1-phosphate receptor Edg-3 : the role of sphingosine_kinase-1 .
21936950	0	sphingosine_kinase-1	17,37	SPHK1	39,44	sphingosine kinase-1	SPHK1	8877	8877	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	An novel role of sphingosine_kinase-1 -LRB- SPHK1 -RRB- in the invasion and metastasis of esophageal_carcinoma .
16414307	0	sphingosine_kinase-1	39,59	epidermal_growth_factor	4,27	sphingosine kinase-1	epidermal growth factor	8877	1950	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	The epidermal_growth_factor stimulates sphingosine_kinase-1 expression and activity in the human mammary carcinoma cell line MCF7 .
24337110	0	sphingosine_kinase-1	77,97	insulin-like_growth_factor-binding_protein-3	14,58	sphingosine kinase-1	insulin-like growth factor-binding protein-3	20698(Tax:10090)	16009(Tax:10090)	Gene	Gene	signaling|advcl|START_ENTITY END_ENTITY|acl|signaling	Inhibition of insulin-like_growth_factor-binding_protein-3 signaling through sphingosine_kinase-1 sensitizes triple-negative_breast_cancer cells to EGF receptor blockade .
24468113	0	sphingosine_kinase-1	8,28	sphingosine_1-phosphate_lyase	42,71	sphingosine kinase-1	sphingosine 1-phosphate lyase	8877	8879	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Reduced sphingosine_kinase-1 and enhanced sphingosine_1-phosphate_lyase expression demonstrate deregulated sphingosine_1-phosphate signaling in Alzheimer 's _ disease .
26540633	0	sphingosine_kinase_1	86,106	HULC	20,24	sphingosine kinase 1	HULC	8877	728655	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Long non-coding RNA HULC promotes tumor angiogenesis in liver_cancer by up-regulating sphingosine_kinase_1 -LRB- SPHK1 -RRB- .
19074142	0	sphingosine_kinase_1	42,62	Interleukin-1	0,13	sphingosine kinase 1	Interleukin-1	8877	3552	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-1 regulates the expression of sphingosine_kinase_1 in glioblastoma cells .
21418911	0	sphingosine_kinase_1	15,35	MUC5AC	71,77	sphingosine kinase 1	MUC5AC	8877	4586	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Regulation of sphingosine_kinase_1 in the TNF-a-induced expression of MUC5AC in airway epithelial cells -RSB- .
26549227	0	sphingosine_kinase_1	63,83	SPHK1	85,90	sphingosine kinase 1	SPHK1	8877	8877	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	MiR-506 suppresses liver_cancer angiogenesis through targeting sphingosine_kinase_1 -LRB- SPHK1 -RRB- mRNA .
16313513	0	sphingosine_kinase_1	14,34	neurotrophin-3	52,66	sphingosine kinase 1	neurotrophin-3	8877	4908	Gene	Gene	START_ENTITY|nmod|mediator mediator|nmod|action action|amod|END_ENTITY	Novel role of sphingosine_kinase_1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors .
25363242	0	sphingosine_kinase_2	68,88	S1P_receptor_2	31,45	sphingosine kinase 2	S1P receptor 2	56632(Tax:10090)	14739(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Conjugated bile_acid-activated S1P_receptor_2 is a key regulator of sphingosine_kinase_2 and hepatic gene expression .
15951439	0	sphingosine_kinase_2	8,28	epidermal_growth_factor	54,77	sphingosine kinase 2	epidermal growth factor	56848	1950	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of sphingosine_kinase_2 in cell migration toward epidermal_growth_factor .
17220882	0	spichthyin	11,21	BMP	31,34	spichthyin	BMP	34681(Tax:7227)	33432(Tax:7227)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules .
15514462	0	spinocerebellar_ataxia_type-1	24,53	SCA1	55,59	spinocerebellar ataxia type-1	SCA1	25049(Tax:10116)	25049(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Prominent expression of spinocerebellar_ataxia_type-1 -LRB- SCA1 -RRB- gene encoding ataxin-1 in LH-producing cells , LbetaT2 .
23719801	0	spinocerebellar_ataxia_type_1	67,96	Nemo-like_kinase	47,63	spinocerebellar ataxia type 1	Nemo-like kinase	20238(Tax:10090)	18099(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nmod|END_ENTITY	Polyglutamine disease toxicity is regulated by Nemo-like_kinase in spinocerebellar_ataxia_type_1 .
8615077	0	spinocerebellar_ataxia_type_1	89,118	SCA-1	120,125	spinocerebellar ataxia type 1	SCA-1	6310	6310	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Structural and immunocytochemical features of olivopontocerebellar_atrophy caused by the spinocerebellar_ataxia_type_1 -LRB- SCA-1 -RRB- mutation define a unique phenotype .
10335546	0	spinocerebellar_ataxia_type_1	80,109	SCA1	111,115	spinocerebellar ataxia type 1	SCA1	6310	6310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible association between schizophrenia and a CAG repeat polymorphism in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene on human chromosome 6p23 .
19597981	0	spinocerebellar_ataxia_type_1	32,61	SCA1	63,67	spinocerebellar ataxia type 1	SCA1	6310	6310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expansion of CAG repeats in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene in idiopathic oligozoospermia patients .
9187671	0	spinocerebellar_ataxia_type_1	54,83	SCA1	85,89	spinocerebellar ataxia type 1	SCA1	6310	6310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of amino-acid and nucleotide variants in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene in schizophrenic patients .
9342197	0	spinocerebellar_ataxia_type_1	46,75	SCA1	77,81	spinocerebellar ataxia type 1	SCA1	6310	6310	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparative studies of the CAG repeats in the spinocerebellar_ataxia_type_1 -LRB- SCA1 -RRB- gene .
8789437	0	spinocerebellar_ataxia_type_1	75,104	Sca1	111,115	spinocerebellar ataxia type 1	Sca1	20238(Tax:10090)	20238(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and developmental expression analysis of the murine homolog of the spinocerebellar_ataxia_type_1 gene -LRB- Sca1 -RRB- .
11136710	0	spinocerebellar_ataxia_type_1	4,33	ataxin-1	43,51	spinocerebellar ataxia type 1	ataxin-1	20238(Tax:10090)	20238(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	The spinocerebellar_ataxia_type_1 protein , ataxin-1 , has RNA-binding activity that is inversely affected by the length of its polyglutamine tract .
18577575	0	spinocerebellar_ataxia_type_14	23,53	PKC_gamma	0,9	spinocerebellar ataxia type 14	PKC gamma	5582	5582	Gene	Gene	mutations|nmod|START_ENTITY mutations|compound|END_ENTITY	PKC_gamma mutations in spinocerebellar_ataxia_type_14 affect C1 domain accessibility and kinase activity leading to aberrant MAPK signaling .
14967767	0	spinocerebellar_ataxia_type_17	105,135	TATA-binding_protein	76,96	spinocerebellar ataxia type 17	TATA-binding protein	6314	6908	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Possible reduced penetrance of expansion of 44 to 47 CAG/CAA repeats in the TATA-binding_protein gene in spinocerebellar_ataxia_type_17 .
20016785	0	spinocerebellar_ataxia_type_2	24,53	ATXN2	55,60	spinocerebellar ataxia type 2	ATXN2	6311	6311	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variance in the spinocerebellar_ataxia_type_2 -LRB- ATXN2 -RRB- gene in children with severe early onset obesity .
23100324	0	spinocerebellar_ataxia_type_3	68,97	ataxin-3	17,25	spinocerebellar ataxia type 3	ataxin-3	110616(Tax:10090)	110616(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar_ataxia_type_3 -LRB- SCA3 -RRB- .
10222783	0	spinocerebellar_ataxia_type_6	60,89	SCA6	91,95	spinocerebellar ataxia type 6	SCA6	773	773	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Clinical , neuropathological and genetic characteristics of spinocerebellar_ataxia_type_6 -LRB- SCA6 -RRB- -RSB- .
15612520	0	spinocerebellar_ataxia_type_6	34,63	SCA6	65,69	spinocerebellar ataxia type 6	SCA6	773	773	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Molecular physiopathology of the spinocerebellar_ataxia_type_6 -LRB- SCA6 -RRB- -RSB- .
24990830	0	spinocerebellar_ataxia_type_6	93,122	SCA6	124,128	spinocerebellar ataxia type 6	SCA6	773	773	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Clinical features and MRI findings in spinocerebellar_ataxia_type_31 -LRB- SCA31 -RRB- comparing with spinocerebellar_ataxia_type_6 -LRB- SCA6 -RRB- -RSB- .
9847668	0	spinocerebellar_ataxia_type_6	35,64	SCA_6	66,71	spinocerebellar ataxia type 6	SCA 6	773	773	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Periodic alternating nystagmus in spinocerebellar_ataxia_type_6 -LRB- SCA_6 -RRB- -RSB- .
12039035	0	spinocerebellar_ataxia_type_7	61,90	SCA7	92,96	spinocerebellar ataxia type 7	SCA7	246103(Tax:10090)	246103(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and expression analysis of the murine homolog of the spinocerebellar_ataxia_type_7 -LRB- SCA7 -RRB- gene .
24374739	0	spinocerebellar_ataxia_type_7	43,72	SCA7	74,78	spinocerebellar ataxia type 7	SCA7	6314	6314	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Founder effect and ancestral origin of the spinocerebellar_ataxia_type_7 -LRB- SCA7 -RRB- mutation in Mexican families .
26154322	0	spleen_tyrosine_kinase	14,36	Syk	38,41	spleen tyrosine kinase	Syk	6850	6850	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of spleen_tyrosine_kinase -LRB- Syk -RRB- at fertilization in Rhinella arenarum eggs .
18439897	0	splicing_factor_SF2	4,23	ASF	24,27	splicing factor SF2	ASF	55147	6426	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|END_ENTITY	The splicing_factor_SF2 / ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1 .
7909605	0	splotch	19,26	Pax-3	43,48	splotch	Pax-3	18505(Tax:10090)	5077	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	Molecular basis of splotch and Waardenburg Pax-3 mutations .
9463628	0	splotch	55,62	Pax3	64,68	splotch	Pax3	18505(Tax:10090)	18505(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Development of a lethal congenital_heart_defect in the splotch -LRB- Pax3 -RRB- mutant mouse .
24069507	0	spp1	43,47	osteopontin	30,41	spp1	osteopontin	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Transgenic mammary epithelial osteopontin -LRB- spp1 -RRB- expression induces proliferation and alveologenesis .
9525990	0	spp1	69,73	osteopontin	51,62	spp1	osteopontin	20750(Tax:10090)	20750(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Altered wound healing in mice lacking a functional osteopontin gene -LRB- spp1 -RRB- .
18253966	0	spp24	19,24	BMP-2	51,56	spp24	BMP-2	281500(Tax:9913)	615037(Tax:9913)	Gene	Gene	spp24|amod|START_ENTITY inhibits|nsubj|spp24 inhibits|dobj|END_ENTITY	Full-length bovine spp24 -LSB- spp24 -LRB- 24-203 -RRB- -RSB- inhibits BMP-2 induced bone formation .
18253966	0	spp24	26,31	BMP-2	51,56	spp24	BMP-2	281500(Tax:9913)	615037(Tax:9913)	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|END_ENTITY	Full-length bovine spp24 -LSB- spp24 -LRB- 24-203 -RRB- -RSB- inhibits BMP-2 induced bone formation .
20162696	0	spp24	52,57	BMP-2	95,100	spp24	BMP-2	6694	650	Gene	Gene	secreted_phosphoprotein-24_kDa|appos|START_ENTITY terminus|nmod|secreted_phosphoprotein-24_kDa essential|nsubj|terminus essential|nmod|inhibition inhibition|nmod|activity activity|compound|END_ENTITY	Carboxy terminus of secreted_phosphoprotein-24_kDa -LRB- spp24 -RRB- is essential for full inhibition of BMP-2 activity .
11231087	0	sprint	26,32	RIN1	60,64	sprint	RIN1	31987(Tax:7227)	31987(Tax:7227)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Cloning and expression of sprint , a Drosophila homologue of RIN1 .
18048363	0	sprouty_2	14,23	H-Ras	62,67	sprouty 2	H-Ras	10253	3265	Gene	Gene	necessary|nsubj|START_ENTITY necessary|nmod|END_ENTITY	Evidence that sprouty_2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts .
12027893	0	sprouty_4	6,15	TESK1	90,95	sprouty 4	TESK1	81848	7016	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human sprouty_4 , a new ras antagonist on 5q31 , interacts with the dual specificity kinase TESK1 .
12083769	0	squalene_epoxidase	67,85	SREBP-2	0,7	squalene epoxidase	SREBP-2	6713	6721	Gene	Gene	regulation|nmod|START_ENTITY involved|nmod|regulation involved|nsubjpass|END_ENTITY	SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene_epoxidase .
24006490	0	srGAP1	0,6	Rac1	82,86	srGAP1	Rac1	57522	5879	Gene	Gene	regulates|nsubj|START_ENTITY regulates|advcl|modulating modulating|dobj|activity activity|amod|END_ENTITY	srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity .
20944010	0	srGAP1	95,101	Slit2	0,5	srGAP1	Slit2	57522	9353	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Slit2 regulates attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung_inflammation .
23505444	0	srGAP2	33,39	srGAP3	53,59	srGAP2	srGAP3	14270(Tax:10090)	259302(Tax:10090)	Gene	Gene	acts|nsubj|START_ENTITY acts|nmod|END_ENTITY	The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells .
23505444	0	srGAP3	53,59	srGAP2	33,39	srGAP3	srGAP2	259302(Tax:10090)	14270(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells .
8388373	0	src	59,62	Phospholipase_C-gamma_1	0,23	src	Phospholipase C-gamma 1	83805(Tax:10116)	25738(Tax:10116)	Gene	Gene	associates|nmod|START_ENTITY associates|amod|END_ENTITY	Phospholipase_C-gamma_1 associates with viral and cellular src kinases .
9584165	0	src	111,114	RACK1	0,5	src	RACK1	20779(Tax:10090)	14694(Tax:10090)	Gene	Gene	kinases|compound|START_ENTITY activity|nmod|kinases inhibits|dobj|activity inhibits|nsubj|END_ENTITY	RACK1 , a receptor_for_activated_C_kinase and a homolog of the beta subunit of G proteins , inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells .
3493323	1	src	111,114	abl	96,99	src	abl	20779(Tax:10090)	11350(Tax:10090)	Gene	Gene	erbB|dep|START_ENTITY erbB|compound|END_ENTITY	Association with expression of abl , ras , fes , src , erbB , and Cas NS-1 oncogenes but not with myc .
2106069	0	src	74,77	epidermal_growth_factor_receptor	14,46	src	epidermal growth factor receptor	83805(Tax:10116)	24329(Tax:10116)	Gene	Gene	product|compound|START_ENTITY caused|nmod|product caused|nsubj|Inhibition Inhibition|nmod|biosynthesis biosynthesis|compound|END_ENTITY	Inhibition of epidermal_growth_factor_receptor biosynthesis caused by the src oncogene product , pp60v-src .
2973411	0	src	40,43	p36	0,3	src	p36	6714	302	Gene	Gene	kinase|compound|START_ENTITY substrate|nmod|kinase END_ENTITY|appos|substrate	p36 , the major cytoplasmic substrate of src tyrosine protein kinase , binds to its p11 regulatory subunit via a short amino-terminal amphiphatic helix .
15872086	0	src	60,63	phospholipase_C-gamma1	136,158	src	phospholipase C-gamma1	6714	5335	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Calcium-induced human keratinocyte differentiation requires src - and fyn-mediated phosphatidylinositol_3-kinase-dependent activation of phospholipase_C-gamma1 .
7516899	0	src	90,93	protein_kinase_C_delta	44,66	src	protein kinase C delta	6714	5580	Gene	Gene	Tyrosine|nmod|START_ENTITY Tyrosine|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	Tyrosine phosphorylation and stimulation of protein_kinase_C_delta from porcine spleen by src in vitro .
6087323	0	src	52,55	src	82,85	src	src	396442(Tax:9031)	396442(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Rous_sarcoma_virus variants that carry the cellular src gene instead of the viral src gene can not transform chicken embryo fibroblasts .
6087323	0	src	82,85	src	52,55	src	src	396442(Tax:9031)	396442(Tax:9031)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|gene gene|compound|END_ENTITY	Rous_sarcoma_virus variants that carry the cellular src gene instead of the viral src gene can not transform chicken embryo fibroblasts .
9681962	0	sst1	45,49	somatostatin_receptor_1	20,43	sst1	somatostatin receptor 1	25033(Tax:10116)	25033(Tax:10116)	Gene	Gene	immunoreactivity|appos|START_ENTITY immunoreactivity|amod|END_ENTITY	The localization of somatostatin_receptor_1 -LRB- sst1 -RRB- immunoreactivity in the rat brain using an N-terminal specific antibody .
10446977	0	sst_2	57,62	somatostatin_receptor_type_2	27,55	sst 2	somatostatin receptor type 2	20606(Tax:10090)	20606(Tax:10090)	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Differential regulation of somatostatin_receptor_type_2 -LRB- sst_2 -RRB- expression in AR4-2J tumor cells implanted into mice during octreotide treatment .
10687849	0	stAR	251,255	steroidogenic_acute_regulatory	219,249	stAR	steroidogenic acute regulatory	6770	6770	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Mechanisms underlying the steroidogenic synergy of insulin and luteinizing hormone in porcine granulosa cells : joint amplification of pivotal sterol-regulatory genes encoding the low-density_lipoprotein _ -LRB- LDL -RRB- _ receptor , steroidogenic_acute_regulatory -LRB- stAR -RRB- protein and cytochrome P450 side-chain cleavage -LRB- P450scc -RRB- enzyme .
9657854	0	stannin	53,60	Snn	62,65	stannin	Snn	20621(Tax:10090)	20621(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Chromosomal localization and characterization of the stannin -LRB- Snn -RRB- gene .
9753616	0	stanniocalcin	36,49	STC2	61,65	stanniocalcin	STC2	8614	8614	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Molecular cloning of a second human stanniocalcin homologue -LRB- STC2 -RRB- .
21465530	0	stanniocalcin-1	36,51	Sp1	0,3	stanniocalcin-1	Sp1	6781	6667	Gene	Gene	expression|amod|START_ENTITY repressor|nmod|expression repressor|nsubj|END_ENTITY	Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon_cancer cells , HT29 .
18164591	0	stanniocalcin-1	45,60	Vascular_endothelial_growth_factor	0,34	stanniocalcin-1	Vascular endothelial growth factor	6781	7422	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Vascular_endothelial_growth_factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast_growth_factor-2 .
21474827	0	stanniocalcin-1	63,78	Vascular_endothelial_growth_factor	0,34	stanniocalcin-1	Vascular endothelial growth factor	6781	7422	Gene	Gene	VEGF-A|amod|START_ENTITY stimulates|dobj|VEGF-A D|acl:relcl|stimulates END_ENTITY|dep|D	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- - D stimulates VEGF-A , stanniocalcin-1 , and neuropilin-2 and has potent angiogenic effects .
22493143	0	stanniocalcin_1	41,56	p53	22,25	stanniocalcin 1	p53	6781	7157	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Synergistic effect of p53 on TSA-induced stanniocalcin_1 expression in human nasopharyngeal_carcinoma cells , CNE2 .
24899578	0	star	37,41	NR2F2	21,26	star	NR2F2	20845(Tax:10090)	11819(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY activates|dobj|expression activates|nsubj|END_ENTITY	The nuclear receptor NR2F2 activates star expression and steroidogenesis in mouse MA-10 and MLTC-1 Leydig cells .
11695844	0	star	136,140	steroidogenic_acute_regulatory_protein	96,134	star	steroidogenic acute regulatory protein	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|compound|END_ENTITY	Inhibition of steroidogenesis in Leydig cells by exogenous nitric_oxide occurs independently of steroidogenic_acute_regulatory_protein -LRB- star -RRB- mRNA .
12122038	0	stargazin	101,110	postsynaptic_density-95	23,46	stargazin	postsynaptic density-95	10369	1742	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Phosphorylation of the postsynaptic_density-95 -LRB- PSD-95 -RRB- / discs large/zona _ occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors .
10674401	0	stat1	110,115	IRF-1	186,191	stat1	IRF-1	6772	3659	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|promoter promoter|compound|END_ENTITY	Association of 2 ' ,5 ' - oligoadenylate_synthetase with the prolactin _ -LRB- PRL -RRB- _ receptor : alteration in PRL-inducible stat1 -LRB- signal_transducer_and_activator_of_transcription_1 -RRB- signaling to the IRF-1 -LRB- interferon-regulatory_factor_1 -RRB- promoter .
22279540	0	stat3	24,29	14-3-3	0,6	stat3	14-3-3	6774	10971	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	14-3-3 interacts with stat3 and regulates its constitutive activation in multiple myeloma cells .
21622714	0	stat3	100,105	Caveolin-1	0,10	stat3	Caveolin-1	6774	857	Gene	Gene	inhibition|amod|START_ENTITY mediates|nmod|inhibition mediates|nsubj|upregulation upregulation|amod|END_ENTITY	Caveolin-1 upregulation mediates suppression of primary breast_tumor growth and brain metastases by stat3 inhibition .
20979115	0	stat3	41,46	ERK1/2	82,88	stat3	ERK1/2	6774	5595;5594	Gene	Gene	activate|dobj|START_ENTITY activate|nmod|cells cells|nmod|receptors receptors|compound|END_ENTITY	HDL and sphingosine-1-phosphate activate stat3 in prostate_cancer DU145 cells via ERK1/2 and S1P receptors , and promote cell migration and invasion .
7528668	0	stat3	76,81	Interleukin-2	0,13	stat3	Interleukin-2	6774	3558	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes .
10639195	0	stat3	79,84	Interleukin-6	0,13	stat3	Interleukin-6	6774	3569	Gene	Gene	activation|nmod|START_ENTITY accompanied|nmod|activation growth|acl|accompanied induces|dobj|growth induces|nsubj|END_ENTITY	Interleukin-6 induces prostate_cancer cell growth accompanied by activation of stat3 signaling pathway .
11150513	0	stat3	105,110	Leukemia_inhibitory_factor	0,26	stat3	Leukemia inhibitory factor	6774	3976	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Leukemia_inhibitory_factor enhances mast cell growth in a mast cell/fibroblast co-culture system through stat3 signaling pathway of fibroblasts .
16397019	0	stat3	14,19	SRC	124,127	stat3	SRC	6774	6714	Gene	Gene	Activation|nmod|START_ENTITY associated|nsubjpass|Activation associated|nmod|levels levels|nmod|END_ENTITY	Activation of stat3 in primary tumors from high-risk breast_cancer patients is associated with elevated levels of activated SRC and survivin expression .
26909593	0	stat3	68,73	egfr	34,38	stat3	egfr	20848(Tax:10090)	13649(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY inhibition|nmod|pathway monotherapy|nmod|inhibition monotherapy|nsubj|resistance resistance|nmod|END_ENTITY	Overcoming resistance of targeted egfr monotherapy by inhibition of stat3 escape pathway in soft tissue sarcoma .
10704821	0	stat3	14,19	gp130	107,112	stat3	gp130	6774	3572	Gene	Gene	Activation|nmod|START_ENTITY DNA|nsubj|Activation DNA|nmod|cytokines cytokines|amod|END_ENTITY	Activation of stat3 and stat1 DNA binding and transcriptional activity in human brain_tumour cell lines by gp130 cytokines .
19400741	0	stat3	43,48	nanog	18,23	stat3	nanog	20848(Tax:10090)	71950(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Nogo-66 regulates nanog expression through stat3 pathway in murine embryonic stem cells .
9915797	1	stat5b	253,259	Growth_hormone	177,191	stat5b	Growth hormone	6777	2688	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubj|inhibition inhibition|amod|END_ENTITY	Growth_hormone inhibition of pparalpha transcriptional activity mediated by stat5b .
11846485	0	stat92E	29,36	STAT	15,19	stat92E	STAT	42428(Tax:7227)	42428(Tax:7227)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	The Drosophila STAT protein , stat92E , regulates follicle cell differentiation during oogenesis .
23637896	0	ste-20	11,17	hippo	41,46	ste-20	hippo	32631(Tax:7227)	37247(Tax:7227)	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Drosophila ste-20 family protein kinase , hippo , modulates fat cell proliferation .
19577469	0	stearoyl-CoA_desaturase	45,68	SCD	70,73	stearoyl-CoA desaturase	SCD	83792(Tax:10116)	83792(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Potent , orally bioavailable , liver-selective stearoyl-CoA_desaturase -LRB- SCD -RRB- inhibitors .
23124221	0	stearoyl-CoA_desaturase	33,56	SCD	58,61	stearoyl-CoA desaturase	SCD	396670(Tax:9823)	396670(Tax:9823)	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of the gene encoding stearoyl-CoA_desaturase -LRB- SCD -RRB- with fatty_acid composition in an intercross population between Landrace and Korean native pigs .
18825276	0	stearoyl-CoA_desaturase	28,51	SCD1	53,57	stearoyl-CoA desaturase	SCD1	6319	6319	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Significant associations of stearoyl-CoA_desaturase -LRB- SCD1 -RRB- gene with fat deposition and composition in skeletal muscle .
15333742	0	stearoyl-CoA_desaturase-1	47,72	Leptin	0,6	stearoyl-CoA desaturase-1	Leptin	6319	3952	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Leptin and the control of metabolism : role for stearoyl-CoA_desaturase-1 -LRB- SCD-1 -RRB- .
24769897	0	stearoyl-CoA_desaturase-1	35,60	ORCTL3	20,26	stearoyl-CoA desaturase-1	ORCTL3	6319	9390	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	The anticancer gene ORCTL3 targets stearoyl-CoA_desaturase-1 for tumour-specific apoptosis .
16741579	0	stearoyl-CoA_desaturase-1	17,42	SCD1	44,48	stearoyl-CoA desaturase-1	SCD1	246074(Tax:10116)	246074(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Critical role of stearoyl-CoA_desaturase-1 -LRB- SCD1 -RRB- in the onset of diet-induced hepatic insulin resistance .
24405703	0	stearoyl-CoA_desaturase-1	76,101	SCD1	103,107	stearoyl-CoA desaturase-1	SCD1	246074(Tax:10116)	246074(Tax:10116)	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	4-Bicyclic_heteroaryl-piperidine derivatives as potent , orally bioavailable stearoyl-CoA_desaturase-1 -LRB- SCD1 -RRB- inhibitors : part 2 .
20723706	0	stearoyl-CoA_desaturase_1	49,74	SCD1	76,80	stearoyl-CoA desaturase 1	SCD1	100860763	100860763	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the polymorphism of the goat stearoyl-CoA_desaturase_1 -LRB- SCD1 -RRB- gene and milk fatty_acid composition in Murciano-Granadina_goats .
7677988	0	steel_factor	42,54	SLF	56,59	steel factor	SLF	17311(Tax:10090)	17311(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Follicle-stimulating hormone induction of steel_factor -LRB- SLF -RRB- mRNA in mouse Sertoli cells and stimulation of DNA synthesis in spermatogonia by soluble SLF .
8639822	0	steel_factor	65,77	Thrombopoietin	0,14	steel factor	Thrombopoietin	17311(Tax:10090)	21832(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Thrombopoietin , the ligand for the Mpl receptor , synergizes with steel_factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice .
8695789	0	steel_factor	93,105	Thrombopoietin	0,14	steel factor	Thrombopoietin	4254	7066	Gene	Gene	supports|nmod|START_ENTITY supports|nsubj|END_ENTITY	Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel_factor and/or interleukin-3 .
7678261	0	steel_factor	77,89	granulocyte-macrophage_colony-stimulating_factor	110,158	steel factor	granulocyte-macrophage colony-stimulating factor	4254	1437	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of immediate-early gene expression in the synergistic effects of steel_factor in combination with granulocyte-macrophage_colony-stimulating_factor or interleukin-3 on proliferation of a human factor-dependent cell line .
1382699	0	steel_factor	93,105	interleukin-9	18,31	steel factor	interleukin-9	4254	3578	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel_factor to stimulate proliferation of the human factor-dependent cell line , M07e .
7535148	0	steel_factor	12,24	stem_cell_factor	26,42	steel factor	stem cell factor	17311(Tax:10090)	17311(Tax:10090)	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of steel_factor -LRB- stem_cell_factor -RRB- isoforms in the hematopoietic microenvironment .
8313966	0	stefin_B	55,63	cathepsin_S	33,44	stefin B	cathepsin S	512805(Tax:9913)	327711(Tax:9913)	Gene	Gene	Kinetics|nmod|START_ENTITY Kinetics|nmod|END_ENTITY	Kinetics of inhibition of bovine cathepsin_S by bovine stefin_B .
25288807	0	stefin_B	11,19	cystatin_B	21,31	stefin B	cystatin B	13014(Tax:10090)	13014(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for stefin_B -LRB- cystatin_B -RRB- in inflammation and endotoxemia .
22907757	0	stem-loop_binding_protein	34,59	Pin1	21,25	stem-loop binding protein	Pin1	7884	5300	Gene	Gene	targets|xcomp|START_ENTITY targets|nsubj|END_ENTITY	The prolyl isomerase Pin1 targets stem-loop_binding_protein -LRB- SLBP -RRB- to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitination .
22238460	0	stem_cell_antigen-1	91,110	ERK	111,114	stem cell antigen-1	ERK	110454(Tax:10090)	26413(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Alcohol impairs the myeloid proliferative response to bacteremia in mice by inhibiting the stem_cell_antigen-1 / ERK pathway .
10729991	0	stem_cell_factor	103,119	C-Kit	59,64	stem cell factor	C-Kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	study|nmod|START_ENTITY cells|dep|study +|dep|cells +|appos|END_ENTITY	Thrombopoietin stimulates murine lineage negative , Sca-1 + , C-Kit + , CD34 - cells : comparative study with stem_cell_factor or interleukin-3 .
10720698	0	stem_cell_factor	104,120	CD34	85,89	stem cell factor	CD34	4254	947	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Effective ex vivo generation of megakaryocytic cells from mobilized peripheral blood CD34 -LRB- + -RRB- cells with stem_cell_factor and promegapoietin .
10729991	0	stem_cell_factor	103,119	CD34	67,71	stem cell factor	CD34	17311(Tax:10090)	12490(Tax:10090)	Gene	Gene	study|nmod|START_ENTITY cells|dep|study +|dep|cells +|appos|C-Kit C-Kit|nummod|END_ENTITY	Thrombopoietin stimulates murine lineage negative , Sca-1 + , C-Kit + , CD34 - cells : comparative study with stem_cell_factor or interleukin-3 .
11796924	0	stem_cell_factor	76,92	CD34	138,142	stem cell factor	CD34	4254	947	Gene	Gene	increase|nmod|START_ENTITY increase|nmod|expansion expansion|nmod|cells cells|compound|END_ENTITY	Decrease in apoptosis and increase in polyploidization of megakaryocytes by stem_cell_factor during ex vivo expansion of human cord blood CD34 + cells using thrombopoietin .
12047434	0	stem_cell_factor	117,133	CD34	75,79	stem cell factor	CD34	4254	947	Gene	Gene	presence|nmod|START_ENTITY cultured|nmod|presence cells|dep|cultured cells|compound|END_ENTITY	Characterization of ` adult-type ' mast cells derived from human bone marrow CD34 -LRB- + -RRB- cells cultured in the presence of stem_cell_factor and interleukin-6 .
12050184	0	stem_cell_factor	51,67	CD34	12,16	stem cell factor	CD34	4254	947	Gene	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated cells|compound|END_ENTITY	Bone marrow CD34 + progenitor cells stimulated with stem_cell_factor and GM-CSF have the capacity to activate IgD - B cells through direct cellular interaction .
12804177	0	stem_cell_factor	150,166	CD34	71,75	stem cell factor	CD34	4254	947	Gene	Gene	amounts|nmod|START_ENTITY presence|nmod|amounts cells|nmod|presence expansion|dep|cells expansion|nmod|megakaryocytes megakaryocytes|nmod|+ +|compound|END_ENTITY	Preferential ex vivo expansion of megakaryocytes from human cord blood CD34 + - enriched cells in the presence of thrombopoietin and limiting amounts of stem_cell_factor and Flt-3_ligand .
1375106	0	stem_cell_factor	126,142	CD34	66,70	stem cell factor	CD34	4254	947	Gene	Gene	presence|nmod|START_ENTITY +|nmod|presence +|nsubj|generation generation|nmod|colony-forming_cells colony-forming_cells|nmod|culture culture|nmod|END_ENTITY	Long-term generation of colony-forming_cells in liquid culture of CD34 + cord blood cells in the presence of recombinant human stem_cell_factor .
1379853	0	stem_cell_factor	34,50	CD34	94,98	stem cell factor	CD34	4254	947	Gene	Gene	c-kit_ligand|appos|START_ENTITY mediates|nsubj|c-kit_ligand mediates|dobj|expansion expansion|nmod|types types|compound|END_ENTITY	A c-kit_ligand , recombinant human stem_cell_factor , mediates reversible expansion of multiple CD34 + colony-forming cell types in blood and marrow of baboons .
1383918	0	stem_cell_factor	24,40	CD34	124,128	stem cell factor	CD34	4254	947	Gene	Gene	effects|nmod|START_ENTITY myeloid|nsubj|effects myeloid|nmod|blood blood|compound|END_ENTITY	The in vitro effects of stem_cell_factor and PIXY321 on myeloid progenitor formation -LRB- CFU-GM -RRB- from immunomagnetic separated CD34 + cord blood .
15196280	0	stem_cell_factor	208,224	CD34	163,167	stem cell factor	CD34	4254	947	Gene	Gene	presence|nmod|START_ENTITY cultured|nmod|presence progenitors|dep|cultured progenitors|compound|END_ENTITY	Functional expression of high-affinity receptor for immunoglobulin E on mast cells precedes that of tryptase during differentiation from human bone marrow-derived CD34 progenitors cultured in the presence of stem_cell_factor and interleukin-6 .
15831091	0	stem_cell_factor	24,40	CD34	0,4	stem cell factor	CD34	4254	947	Gene	Gene	cultured|nmod|START_ENTITY cells|acl|cultured cells|nummod|END_ENTITY	CD34 + cells cultured in stem_cell_factor and interleukin-2 generate CD56 + cells with antiproliferative effects on tumor cell lines .
1710148	0	stem_cell_factor	18,34	CD34	155,159	stem cell factor	CD34	4254	947	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|lin lin|compound|END_ENTITY	Recombinant human stem_cell_factor enhances the formation of colonies by CD34 + and CD34 + lin - cells , and the generation of colony-forming cell progeny from CD34 + lin - cells cultured with interleukin-3 , granulocyte_colony-stimulating_factor , or granulocyte-macrophage_colony-stimulating_factor .
1710148	0	stem_cell_factor	18,34	CD34	73,77	stem cell factor	CD34	4254	947	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|formation formation|nmod|colonies colonies|nmod|+ +|compound|END_ENTITY	Recombinant human stem_cell_factor enhances the formation of colonies by CD34 + and CD34 + lin - cells , and the generation of colony-forming cell progeny from CD34 + lin - cells cultured with interleukin-3 , granulocyte_colony-stimulating_factor , or granulocyte-macrophage_colony-stimulating_factor .
21963880	0	stem_cell_factor	31,47	CD34	89,93	stem cell factor	CD34	574254(Tax:9544)	713858(Tax:9544)	Gene	Gene	START_ENTITY|xcomp|improve improve|nmod|transplantation transplantation|compound|END_ENTITY	Keratinocyte_growth_factor and stem_cell_factor to improve thymopoiesis after autologous CD34 + cell transplantation in rhesus_macaques .
7524746	0	stem_cell_factor	106,122	CD34	67,71	stem cell factor	CD34	4254	947	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|generation generation|nmod|cells cells|nmod|cultures cultures|nmod|cells cells|compound|END_ENTITY	Long-term generation of human mast cells in serum-free cultures of CD34 + cord blood cells stimulated with stem_cell_factor and interleukin-3 .
7525328	0	stem_cell_factor	58,74	CD34	107,111	stem cell factor	CD34	4254	947	Gene	Gene	exit|nmod|START_ENTITY confers|dep|exit confers|nmod|cells cells|compound|END_ENTITY	Rapid exit from G0/G1 phases of cell cycle in response to stem_cell_factor confers on umbilical cord blood CD34 + cells an enhanced ex vivo expansion potential .
7552984	0	stem_cell_factor	47,63	CD34	108,112	stem cell factor	CD34	574254(Tax:9544)	713858(Tax:9544)	Gene	Gene	START_ENTITY|nmod|transduction transduction|nmod|cells cells|compound|END_ENTITY	Influence of interleukin-3 , interleukin-6 , and stem_cell_factor on retroviral transduction of rhesus_monkey CD34 + hematopoietic progenitor cells measured in vitro and in vivo .
7694867	0	stem_cell_factor	117,133	CD34	67,71	stem cell factor	CD34	4254	947	Gene	Gene	cells|nmod|START_ENTITY proliferation|dep|cells proliferation|nmod|+ +|compound|END_ENTITY	Interleukin-11 stimulates the proliferation of human hematopoietic CD34 + and CD34 + CD33-DR - cells and synergizes with stem_cell_factor , interleukin-3 , and granulocyte-macrophage_colony-stimulating_factor .
9885212	0	stem_cell_factor	47,63	CD34	88,92	stem cell factor	CD34	4254	947	Gene	Gene	combination|nmod|START_ENTITY production|nmod|combination production|nmod|END_ENTITY	Neutrophilic cell production by combination of stem_cell_factor and thrombopoietin from CD34 -LRB- + -RRB- cord blood cells in long-term serum-deprived liquid culture .
9933129	0	stem_cell_factor	38,54	CD34	98,102	stem cell factor	CD34	4254	947	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|growth growth|nmod|cells cells|compound|END_ENTITY	Role of physiologic concentrations of stem_cell_factor in leukemic type growth of myelodysplastic CD34 + cells .
9256427	0	stem_cell_factor	20,36	Chymase	0,7	stem cell factor	Chymase	4254	1215	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Chymase cleavage of stem_cell_factor yields a bioactive , soluble product .
19492092	0	stem_cell_factor	30,46	Erythropoietin	0,14	stem cell factor	Erythropoietin	17311(Tax:10090)	13856(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Erythropoietin down-regulates stem_cell_factor receptor -LRB- Kit -RRB- expression in the leukemic proerythroblast : role of Lyn kinase .
7507758	0	stem_cell_factor	12,28	G-CSF	96,101	stem cell factor	G-CSF	17311(Tax:10090)	100036204(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|synergy synergy|nmod|END_ENTITY	The role of stem_cell_factor in mobilization of peripheral blood progenitor cells : synergy with G-CSF .
7681048	0	stem_cell_factor	23,39	G-CSF	70,75	stem cell factor	G-CSF	60427(Tax:10116)	25610(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	Hematologic effects of stem_cell_factor alone and in combination with G-CSF and GM-CSF in vivo and in vitro in rodents .
9712486	0	stem_cell_factor	111,127	G-CSF	101,106	stem cell factor	G-CSF	17311(Tax:10090)	100036204(Tax:10090)	Gene	Gene	as|nmod:npmod|START_ENTITY mobilized|advmod|as mobilized|nmod|END_ENTITY	Superior antileukemic activity of murine peripheral blood progenitor cell -LRB- PBPC -RRB- grafts mobilized by G-CSF and stem_cell_factor -LRB- SCF -RRB- as compared to G-CSF alone .
1704845	0	stem_cell_factor	18,34	GM-CSF	51,57	stem cell factor	GM-CSF	4254	1437	Gene	Gene	synergises|nsubj|START_ENTITY synergises|nmod|END_ENTITY	Recombinant human stem_cell_factor synergises with GM-CSF , G-CSF , IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages .
23565130	0	stem_cell_factor	58,74	Granulocyte-colony_stimulating_factor	0,37	stem cell factor	Granulocyte-colony stimulating factor	60427(Tax:10116)	25610(Tax:10116)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Granulocyte-colony_stimulating_factor in combination with stem_cell_factor confers greater neuroprotection after hypoxic-ischemic_brain_damage in the neonatal rats than a solitary treatment .
14688333	0	stem_cell_factor	108,124	IL-3	126,130	stem cell factor	IL-3	4254	3562	Gene	Gene	IL-4|compound|START_ENTITY IL-4|dep|END_ENTITY	Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem_cell_factor , IL-3 , IL-4 , and nerve growth factor .
10749580	0	stem_cell_factor	50,66	IL-6	120,124	stem cell factor	IL-6	4254	3569	Gene	Gene	cells|nmod|START_ENTITY Expansion|nmod|cells _|nsubj|Expansion _|dobj|receptor receptor|amod|END_ENTITY	Expansion of human NOD/SCID-repopulating cells by stem_cell_factor , Flk2/Flt3 _ ligand , thrombopoietin , IL-6 , and soluble IL-6 receptor .
8913284	0	stem_cell_factor	145,161	IL-8	116,120	stem cell factor	IL-8	17311(Tax:10090)	20309(Tax:10090)	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nmod|END_ENTITY	Improved survival of lethally irradiated recipient mice transplanted with circulating progenitor cells mobilized by IL-8 after pretreatment with stem_cell_factor .
21092510	0	stem_cell_factor	54,70	Insulin-like_growth_factor_1	1,29	stem cell factor	Insulin-like growth factor 1	60427(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	-LSB- Insulin-like_growth_factor_1 regulates expression of stem_cell_factor through ERKMAPK signaling pathway in gastric smooth muscle cell -RSB- .
7694867	0	stem_cell_factor	117,133	Interleukin-11	0,14	stem cell factor	Interleukin-11	4254	3589	Gene	Gene	cells|nmod|START_ENTITY proliferation|dep|cells stimulates|dobj|proliferation stimulates|nsubj|END_ENTITY	Interleukin-11 stimulates the proliferation of human hematopoietic CD34 + and CD34 + CD33-DR - cells and synergizes with stem_cell_factor , interleukin-3 , and granulocyte-macrophage_colony-stimulating_factor .
25418470	0	stem_cell_factor	60,76	Interleukin-1_beta	0,18	stem cell factor	Interleukin-1 beta	4254	3553	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_beta induces the expression and production of stem_cell_factor by epithelial cells : crucial involvement of the PI-3K / mTOR pathway and HIF-1 transcription complex .
11166453	0	stem_cell_factor	60,76	Interleukin-6	0,13	stem cell factor	Interleukin-6	17311(Tax:10090)	3569	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Interleukin-6 and the soluble interleukin-6 receptor induce stem_cell_factor and Flt-3L expression in vivo and in vitro .
8519688	0	stem_cell_factor	63,79	Interleukin_4	0,13	stem cell factor	Interleukin 4	4254	3565	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Interleukin_4 down-regulates expression of c-kit and autocrine stem_cell_factor in human colorectal_carcinoma cells .
11874486	0	stem_cell_factor	120,136	KIT	137,140	stem cell factor	KIT	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	proliferation|nmod|START_ENTITY proliferation|dep|END_ENTITY	Transforming_growth_factor_beta1 regulates melanocyte proliferation and differentiation in mouse neural crest cells via stem_cell_factor / KIT signaling .
12444320	0	stem_cell_factor	39,55	KIT	66,69	stem cell factor	KIT	4254	3815	Gene	Gene	receptor|compound|START_ENTITY cells|nmod|receptor Activation|nmod|cells Activation|appos|END_ENTITY	Activation of human mast cells through stem_cell_factor receptor -LRB- KIT -RRB- is associated with expression of bcl-2 .
17662946	0	stem_cell_factor	71,87	KIT	64,67	stem cell factor	KIT	4254	3815	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Structural basis for activation of the receptor tyrosine kinase KIT by stem_cell_factor .
18830255	0	stem_cell_factor	16,32	KIT	33,36	stem cell factor	KIT	4254	3815	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	The key role of stem_cell_factor / KIT signaling in the proliferation of blast cells from Down syndrome-related_leukemia .
20857409	0	stem_cell_factor	51,67	KIT	0,3	stem cell factor	KIT	4254	3815	Gene	Gene	growth|compound|START_ENTITY activation|nmod|growth activation|nsubj|receptor receptor|compound|END_ENTITY	KIT receptor activation by autocrine and paracrine stem_cell_factor stimulates growth of merkel_cell_carcinoma in vitro .
16647379	0	stem_cell_factor	27,43	KIT_ligand	44,54	stem cell factor	KIT ligand	4254	4254	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Investigation of the human stem_cell_factor KIT_ligand gene , KITLG , in women with 46 , XX spontaneous premature_ovarian_failure .
18602222	0	stem_cell_factor	14,30	KIT_ligand	40,50	stem cell factor	KIT ligand	4254	4254	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- , a KIT_ligand , in gastrointestinal_stromal_tumors -LRB- GISTs -RRB- : a potential marker for tumor proliferation .
11307935	0	stem_cell_factor	36,52	Kit	14,17	stem cell factor	Kit	281885(Tax:9913)	280832(Tax:9913)	Gene	Gene	receptor|nmod|START_ENTITY Expression|appos|receptor Expression|nmod|END_ENTITY	Expression of Kit , the receptor for stem_cell_factor , in bovine peripheral blood .
24999927	0	stem_cell_factor	4,20	Kit	21,24	stem cell factor	Kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|regulates regulates|nsubj|signalling signalling|compound|END_ENTITY	The stem_cell_factor / Kit signalling pathway regulates mitochondrial function and energy expenditure .
8636116	0	stem_cell_factor	6,22	Kit	109,112	stem cell factor	Kit	4254	3815	Gene	Gene	dimer|compound|START_ENTITY forms|nsubj|dimer forms|dobj|domain domain|nmod|receptor receptor|appos|END_ENTITY	Human stem_cell_factor dimer forms a complex with two molecules of the extracellular domain of its receptor , Kit .
16533754	0	stem_cell_factor	18,34	RabGEF1	0,7	stem cell factor	RabGEF1	17311(Tax:10090)	56715(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	RabGEF1 regulates stem_cell_factor / c-Kit-mediated signaling events and biological responses in mast cells .
1375477	0	stem_cell_factor	26,42	SCF	44,47	stem cell factor	SCF	4254	4254	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of recombinant stem_cell_factor -LRB- SCF -RRB- on purified CD34-positive human umbilical cord blood progenitor cells .
14563684	0	stem_cell_factor	17,33	SCF	35,38	stem cell factor	SCF	4254	4254	Gene	Gene	Transcription|nmod|START_ENTITY Transcription|appos|END_ENTITY	Transcription of stem_cell_factor -LRB- SCF -RRB- is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element .
14662725	0	stem_cell_factor	46,62	SCF	64,67	stem cell factor	SCF	4254	4254	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Paradoxical early glucocorticoid induction of stem_cell_factor -LRB- SCF -RRB- expression in inflammatory conditions .
1717499	0	stem_cell_factor	29,45	SCF	47,50	stem cell factor	SCF	4254	4254	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of recombinant human stem_cell_factor -LRB- SCF -RRB- on the growth of human progenitor cells in vitro .
18602222	0	stem_cell_factor	14,30	SCF	32,35	stem cell factor	SCF	4254	4254	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of stem_cell_factor -LRB- SCF -RRB- , a KIT_ligand , in gastrointestinal_stromal_tumors -LRB- GISTs -RRB- : a potential marker for tumor proliferation .
7517201	0	stem_cell_factor	11,27	SCF	29,32	stem cell factor	SCF	4254	4254	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of stem_cell_factor -LRB- SCF -RRB- on human marrow neutrophil , neutrophil/macrophage mixed , macrophage and eosinophil progenitor cell growth .
7693028	0	stem_cell_factor	11,27	SCF	29,32	stem cell factor	SCF	4254	4254	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of stem_cell_factor -LRB- SCF -RRB- on the in vitro growth of leukemic blast progenitors in acute_non-lymphocytic_leukemia .
9209436	0	stem_cell_factor	12,28	SCF	30,33	stem cell factor	SCF	4254	4254	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Role of the stem_cell_factor -LRB- SCF -RRB- receptor and the alternative forms of its ligand -LRB- SCF -RRB- in the induction of long-term growth by stroma cells .
9209436	0	stem_cell_factor	12,28	SCF	85,88	stem cell factor	SCF	4254	4254	Gene	Gene	receptor|compound|START_ENTITY Role|nmod|receptor Role|appos|END_ENTITY	Role of the stem_cell_factor -LRB- SCF -RRB- receptor and the alternative forms of its ligand -LRB- SCF -RRB- in the induction of long-term growth by stroma cells .
16155937	0	stem_cell_factor	144,160	bone_morphogenetic_protein_type_II_receptor	75,118	stem cell factor	bone morphogenetic protein type II receptor	17311(Tax:10090)	12168(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Interaction and functional cooperation between the serine/threonine kinase bone_morphogenetic_protein_type_II_receptor with the tyrosine kinase stem_cell_factor receptor .
17145782	0	stem_cell_factor	102,118	c-Jun	35,40	stem cell factor	c-Jun	17311(Tax:10090)	16476(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induces|nmod|induction induces|nsubj|END_ENTITY	Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem_cell_factor .
26592659	0	stem_cell_factor	28,44	c-KIT	51,56	stem cell factor	c-KIT	4254	3815	Gene	Gene	down-regulate|dep|START_ENTITY down-regulate|dep|system system|amod|END_ENTITY	Estrogens down-regulate the stem_cell_factor -LRB- SCF -RRB- / c-KIT system in prostate cells : Evidence of antiproliferative and proapoptotic effects .
8889703	0	stem_cell_factor	36,52	c-KIT	14,19	stem cell factor	c-KIT	4254	3815	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of c-KIT and its ligand , stem_cell_factor , in normal and subfertile human testicular tissue .
15145934	0	stem_cell_factor	9,25	c-Kit	26,31	stem cell factor	c-Kit	4254	3815	Gene	Gene	Roles|nmod|START_ENTITY Roles|dep|END_ENTITY	Roles of stem_cell_factor / c-Kit and effects of Glivec/STI571 in human uveal_melanoma cell tumorigenesis .
15308671	0	stem_cell_factor	22,38	c-Kit	154,159	stem cell factor	c-Kit	4254	3815	Gene	Gene	growth|nmod|START_ENTITY involves|nsubj|growth involves|nmod|END_ENTITY	Synergistic growth of stem_cell_factor and granulocyte_macrophage_colony-stimulating_factor involves kinase-dependent and - independent contributions from c-Kit .
17493588	0	stem_cell_factor	18,34	c-Kit	41,46	stem cell factor	c-Kit	4254	3815	Gene	Gene	inhibited|dep|START_ENTITY inhibited|dep|proliferation proliferation|amod|END_ENTITY	Chrysin inhibited stem_cell_factor -LRB- SCF -RRB- / c-Kit complex-induced cell proliferation in human myeloid_leukemia cells .
18054864	0	stem_cell_factor	22,38	c-Kit	39,44	stem cell factor	c-Kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	tuning|nmod|START_ENTITY END_ENTITY|dep|tuning	Nociceptive tuning by stem_cell_factor / c-Kit signaling .
18598300	0	stem_cell_factor	37,53	c-Kit	54,59	stem cell factor	c-Kit	4254	3815	Gene	Gene	enhances|nmod|START_ENTITY END_ENTITY|dep|enhances	Geniposide enhances melanogenesis by stem_cell_factor / c-Kit signalling in norepinephrine-exposed normal human epidermal melanocyte .
24626629	0	stem_cell_factor	20,36	c-Kit	78,83	stem cell factor	c-Kit	4254	3815	Gene	Gene	Co-stimulation|nmod|START_ENTITY enhances|nsubj|Co-stimulation enhances|dobj|migration migration|nmod|END_ENTITY	Co-stimulation with stem_cell_factor and erythropoietin enhances migration of c-Kit expressing cervical cancer cells through the sustained activation of ERK1/2 .
24921944	0	stem_cell_factor	42,58	c-Kit	69,74	stem cell factor	c-Kit	4254	3815	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A human monoclonal antibody targeting the stem_cell_factor receptor -LRB- c-Kit -RRB- blocks_tumor cell signaling and inhibits tumor growth .
27040393	0	stem_cell_factor	38,54	c-Kit	4,9	Stem Cell Factor	c-Kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY level|acl|induced level|amod|END_ENTITY	Low c-Kit expression level induced by stem_cell_factor does not compromise transplantation of hematopoietic stem cells .
7542059	0	stem_cell_factor	34,50	c-Kit	12,17	stem cell factor	c-Kit	4254	3815	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	The role of c-Kit and its ligand , stem_cell_factor , in mast cell apoptosis .
10792276	0	stem_cell_factor	102,118	c-kit	29,34	stem cell factor	c-kit	4254	3815	Gene	Gene	characterized|nmod|START_ENTITY characterized|nsubjpass|cells cells|acl|bearing bearing|dobj|mutation mutation|amod|END_ENTITY	Mastocytosis cells bearing a c-kit activating point mutation are characterized by hypersensitivity to stem_cell_factor and increased apoptosis .
11286626	0	stem_cell_factor	22,38	c-kit	39,44	stem cell factor	c-kit	4254	3815	Gene	Gene	role|nmod|START_ENTITY role|parataxis|signaling signaling|nsubj|END_ENTITY	The paracrine role of stem_cell_factor / c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation .
12199785	0	stem_cell_factor	185,201	c-kit	52,57	stem cell factor	c-kit	4254	3815	Gene	Gene	express|nmod|START_ENTITY express|dobj|receptors receptors|amod|END_ENTITY	Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin 's _ disease-involved lymph nodes through soluble and membrane-bound stem_cell_factor .
12322893	0	stem_cell_factor	40,56	c-kit	57,62	stem cell factor	c-kit	4254	3815	Gene	Gene	START_ENTITY|dep|system system|amod|END_ENTITY	Molecular genetics of male_infertility : stem_cell_factor / c-kit system .
1280476	0	stem_cell_factor	22,38	c-kit	15,20	stem cell factor	c-kit	4254	3815	Gene	Gene	ligand|appos|START_ENTITY ligand|nmod|END_ENTITY	The ligand for c-kit , stem_cell_factor , stimulates the circulation of cells that engraft lethally irradiated baboons .
1375244	0	stem_cell_factor	70,86	c-kit	105,110	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	START_ENTITY|appos|ligand ligand|nmod|receptor receptor|amod|END_ENTITY	Stimulation of mouse connective tissue-type mast cells by hemopoietic stem_cell_factor , a ligand for the c-kit receptor .
1375870	0	stem_cell_factor	18,34	c-kit	98,103	stem cell factor	c-kit	4254	3815	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|growth growth|nmod|line line|acl|expressing expressing|dobj|protooncogene protooncogene|amod|END_ENTITY	Recombinant human stem_cell_factor stimulates growth of a human glioblastoma cell line expressing c-kit protooncogene .
1378316	0	stem_cell_factor	42,58	c-kit	71,76	stem cell factor	c-kit	4254	3815	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Nonhematopoietic_tumor cell lines express stem_cell_factor and display c-kit receptors .
14666642	0	stem_cell_factor	14,30	c-kit	43,48	stem cell factor	c-kit	4254	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|expression expression|amod|END_ENTITY	Expression of stem_cell_factor and lack of c-kit expression in malignant_fibrous_histiocytoma of soft tissues .
17026507	0	stem_cell_factor	14,30	c-kit	49,54	stem cell factor	c-kit	4254	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of stem_cell_factor and its receptor , c-kit , in human oral mesenchymal cells .
17044945	0	stem_cell_factor	4,20	c-kit	21,26	stem cell factor	c-kit	4254	3815	Gene	Gene	START_ENTITY|parataxis|enhances enhances|nsubj|receptor receptor|amod|END_ENTITY	The stem_cell_factor / c-kit receptor pathway enhances proliferation and invasion of pancreatic_cancer cells .
1714329	0	stem_cell_factor	44,60	c-kit	73,78	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	hematopoiesis|nmod|START_ENTITY effects|nmod|hematopoiesis effects|dep|ligand ligand|nmod|END_ENTITY	The effects on hematopoiesis of recombinant stem_cell_factor -LRB- ligand for c-kit -RRB- administered in vivo to mice either alone or in combination with granulocyte_colony-stimulating_factor .
1715219	0	stem_cell_factor	80,96	c-kit	109,114	stem cell factor	c-kit	60427(Tax:10116)	16590(Tax:10090)	Gene	Gene	culture|nmod|START_ENTITY formation|nmod|culture Enhancement|nmod|formation ligand|nsubj|Enhancement ligand|nmod|END_ENTITY	Enhancement of murine blast cell colony formation in culture by recombinant rat stem_cell_factor , ligand for c-kit .
18006465	0	stem_cell_factor	19,35	c-kit	95,100	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	injection|nmod|START_ENTITY improves|nsubj|injection improves|ccomp|delivered delivered|iobj|bone bone|amod|END_ENTITY	Local injection of stem_cell_factor -LRB- SCF -RRB- improves myocardial homing of systemically delivered c-kit + bone marrow-derived stem cells .
18423881	0	stem_cell_factor	15,31	c-kit	65,70	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY tyrosine|nsubj|Involvement tyrosine|dobj|END_ENTITY	Involvement of stem_cell_factor and its receptor tyrosine kinase c-kit in pain regulation .
19675587	0	stem_cell_factor	21,37	c-kit	38,43	stem cell factor	c-kit	4254	3815	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|dep|expression expression|amod|END_ENTITY	Relationship between stem_cell_factor / c-kit expression in peripheral blood and blood pressure .
20377480	0	stem_cell_factor	10,26	c-kit	94,99	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	improves|nsubj|START_ENTITY improves|nmod|blockade blockade|nmod|END_ENTITY	Exogenous stem_cell_factor improves interstitial cells of Cajal restoration after blockade of c-kit signaling pathway .
20596251	0	stem_cell_factor	14,30	c-kit	31,36	stem cell factor	c-kit	4254	3815	Gene	Gene	Expression|nmod|START_ENTITY Expression|parataxis|signaling signaling|nsubj|END_ENTITY	Expression of stem_cell_factor / c-kit signaling pathway components in diabetic_fibrovascular_epiretinal_membranes .
22349512	0	stem_cell_factor	66,82	c-kit	17,22	stem cell factor	c-kit	4254	3815	Gene	Gene	secretion|nmod|START_ENTITY controlling|dobj|secretion regulates|advcl|controlling regulates|dobj|expression expression|amod|END_ENTITY	Rab27b regulates c-kit expression by controlling the secretion of stem_cell_factor .
22562362	0	stem_cell_factor	77,93	c-kit	94,99	stem cell factor	c-kit	4254	3815	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Endothelial cell-fatty_acid_binding_protein_4 promotes angiogenesis : role of stem_cell_factor / c-kit pathway .
26428235	0	stem_cell_factor	72,88	c-kit	10,15	stem cell factor	c-kit	4254	3815	Gene	Gene	using|dobj|START_ENTITY neuroblastomas|acl|using Targeting|nmod|neuroblastomas Targeting|dobj|receptor receptor|amod|END_ENTITY	Targeting c-kit receptor in neuroblastomas and colorectal_cancers using stem_cell_factor -LRB- SCF -RRB- - based recombinant bacterial toxins .
26705118	0	stem_cell_factor	14,30	c-kit	31,36	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	Antagonism|nmod|START_ENTITY Antagonism|parataxis|neonatal neonatal|nsubj|attenuates attenuates|amod|END_ENTITY	Antagonism of stem_cell_factor / c-kit signaling attenuates neonatal chronic hypoxia-induced pulmonary_vascular remodeling .
7506674	0	stem_cell_factor	43,59	c-kit	89,94	stem cell factor	c-kit	4254	3815	Gene	Gene	differentiation|nmod|START_ENTITY Inhibition|nmod|differentiation Inhibition|acl|expressing expressing|dobj|gene gene|amod|END_ENTITY	Inhibition of erythroid differentiation by stem_cell_factor in K562 cells expressing the c-kit gene .
7514454	0	stem_cell_factor	33,49	c-kit	60,65	stem cell factor	c-kit	4254	3815	Gene	Gene	receptor|compound|START_ENTITY density|nmod|receptor Regulation|nmod|density Regulation|appos|END_ENTITY	Regulation of the density of the stem_cell_factor receptor -LRB- c-kit -RRB- by tumor_necrosis_factor_alpha on a human myeloid cell line .
7527665	0	stem_cell_factor	23,39	c-kit	178,183	stem cell factor	c-kit	4254	3815	Gene	Gene	actions|nmod|START_ENTITY +|nsubj|actions +|dobj|progenitors progenitors|acl|expressing expressing|dobj|levels levels|nmod|protein protein|amod|END_ENTITY	Synergistic actions of stem_cell_factor and other burst-promoting activities on proliferation of CD34 + highly purified blood progenitors expressing HLA-DR or different levels of c-kit protein .
7527782	0	stem_cell_factor	15,31	c-kit	0,5	stem cell factor	c-kit	4254	3815	Gene	Gene	receptor|compound|START_ENTITY protein|appos|receptor protein|amod|END_ENTITY	c-kit protein -LRB- stem_cell_factor receptor -RRB- expression on cells with erythroid characteristics and on normal human bone marrow without the use of monoclonal antibodies .
7543307	0	stem_cell_factor	63,79	c-kit	11,16	stem cell factor	c-kit	4254	3815	Gene	Gene	proliferative|advcl|START_ENTITY proliferative|nsubj|Absence Absence|nmod|receptor receptor|amod|END_ENTITY	Absence of c-kit receptor and absent proliferative response to stem_cell_factor in childhood Burkitt 's lymphoma cells .
7680037	0	stem_cell_factor	94,110	c-kit	8,13	stem cell factor	c-kit	4254	3815	Gene	Gene	site|nmod|START_ENTITY confine|dobj|site confine|nsubj|proteins proteins|amod|END_ENTITY	Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem_cell_factor .
7680956	0	stem_cell_factor	18,34	c-kit	118,123	stem cell factor	c-kit	4254	3815	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|chemotaxis chemotaxis|nmod|lines lines|acl|expressing expressing|dobj|protooncogene protooncogene|amod|END_ENTITY	Recombinant human stem_cell_factor mediates chemotaxis of small-cell_lung_cancer cell lines aberrantly expressing the c-kit protooncogene .
7682764	0	stem_cell_factor	20,36	c-kit	4,9	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	The c-kit receptor , stem_cell_factor , and mast cells .
7687925	0	stem_cell_factor	89,105	c-kit	179,184	stem cell factor	c-kit	4254	3815	Gene	Gene	activity|nmod|START_ENTITY interferes|nmod|activity interferes|nmod|down-regulation down-regulation|nmod|product product|amod|END_ENTITY	Transforming_growth_factor-beta_1 interferes with the proliferation-inducing activity of stem_cell_factor in myelogenous_leukemia blasts through functional down-regulation of the c-kit proto-oncogene product .
8519688	0	stem_cell_factor	63,79	c-kit	43,48	stem cell factor	c-kit	4254	3815	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Interleukin_4 down-regulates expression of c-kit and autocrine stem_cell_factor in human colorectal_carcinoma cells .
8605335	0	stem_cell_factor	31,47	c-kit	85,90	stem cell factor	c-kit	4254	16590(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY mimics|nsubj|expression mimics|dobj|mutations mutations|amod|END_ENTITY	Xenogeneic expression of human stem_cell_factor in transgenic_mice mimics codominant c-kit mutations .
8605337	0	stem_cell_factor	137,153	c-kit	154,159	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	interaction|compound|START_ENTITY interaction|amod|END_ENTITY	A novel hematopoietic multilineage clone , Myl-D-7 , is stromal cell-dependent and supported by an alternative mechanism -LRB- s -RRB- independent of stem_cell_factor / c-kit interaction .
8691142	0	stem_cell_factor	11,27	c-kit	35,40	stem cell factor	c-kit	17311(Tax:10090)	16590(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|interaction interaction|amod|END_ENTITY	A role for stem_cell_factor -LRB- SCF -RRB- : c-kit interaction -LRB- s -RRB- in the intestinal tract response to Salmonella_typhimurium infection .
8780889	0	stem_cell_factor	154,170	c-kit	72,77	stem cell factor	c-kit	4254	3815	Gene	Gene	cells|nmod|START_ENTITY express|nmod|cells express|dobj|receptors receptors|amod|END_ENTITY	Human osteoclasts and preosteoclast cells -LRB- FLG 29.1 -RRB- express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem_cell_factor .
9004081	0	stem_cell_factor	14,30	c-kit	41,46	stem cell factor	c-kit	17311(Tax:10090)	3815	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|appos|END_ENTITY	Expression of stem_cell_factor receptor -LRB- c-kit -RRB- by the malignant mast cells from spontaneous canine mast_cell_tumours .
9221761	0	stem_cell_factor	75,91	c-kit	56,61	stem cell factor	c-kit	4254	3815	Gene	Gene	receptor|nmod|START_ENTITY receptor|amod|END_ENTITY	Human peripheral blood eosinophils express a functional c-kit receptor for stem_cell_factor that stimulates very late antigen 4 -LRB- VLA-4 -RRB- - mediated cell adhesion to fibronectin and vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- .
9444944	0	stem_cell_factor	30,46	c-kit	195,200	stem cell factor	c-kit	4254	3815	Gene	Gene	synergism|nmod|START_ENTITY Analysis|nmod|synergism Analysis|dep|increase increase|nmod|phosphorylation phosphorylation|nmod|subunit subunit|nmod|END_ENTITY	Analysis of synergism between stem_cell_factor and granulocyte-macrophage_colony-stimulating_factor on human megakaryoblastic cells : an increase in tyrosine phosphorylation of 145 kDa subunit of c-kit in two-factor combination .
9697876	0	stem_cell_factor	60,76	c-kit	29,34	stem cell factor	c-kit	4254	3815	Gene	Gene	Expression|acl|START_ENTITY Expression|nmod|receptor receptor|amod|END_ENTITY	Expression and regulation of c-kit receptor and response to stem_cell_factor in childhood malignant T-lymphoblastic cells .
9746752	0	stem_cell_factor	12,28	c-kit	39,44	stem cell factor	c-kit	4254	3815	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Ontogeny of stem_cell_factor receptor -LRB- c-kit -RRB- messenger ribonucleic_acid in the ovine corpus luteum .
9797132	0	stem_cell_factor	14,30	c-kit	49,54	stem cell factor	c-kit	4254	3815	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of stem_cell_factor and expression of c-kit in human rhabdomyosarcoma cells : lack of autocrine growth modulation .
17556359	0	stem_cell_factor	50,66	early_growth_response_factor-1	4,34	stem cell factor	early growth response factor-1	17311(Tax:10090)	13653(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The early_growth_response_factor-1 is involved in stem_cell_factor -LRB- SCF -RRB- - induced interleukin_13 production by mast cells , but is dispensable for SCF-dependent mast cell growth .
16356735	0	stem_cell_factor	31,47	erythropoietin	59,73	stem cell factor	erythropoietin	4254	2056	Gene	Gene	expression|nmod|START_ENTITY fused|nsubj|expression fused|nmod|peptide peptide|compound|END_ENTITY	High-level expression of human stem_cell_factor fused with erythropoietin mimetic peptide in Escherichia_coli .
7528591	0	stem_cell_factor	45,61	erythropoietin	14,28	stem cell factor	erythropoietin	4254	2056	Gene	Gene	Synergy|appos|START_ENTITY Synergy|nmod|END_ENTITY	Synergy among erythropoietin , interleukin_3 , stem_cell_factor -LRB- c-kit_ligand -RRB- and interferon-gamma on early human hematopoiesis .
9642254	0	stem_cell_factor	101,117	erythropoietin	83,97	stem cell factor	erythropoietin	4254	2056	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|gene gene|nmod|responsiveness responsiveness|nmod|END_ENTITY	Induction of the erythropoietin_receptor gene and acquisition of responsiveness to erythropoietin by stem_cell_factor in HML/SE , a human leukemic cell line .
9816264	0	stem_cell_factor	42,58	erythropoietin	127,141	stem cell factor	erythropoietin	4254	2056	Gene	Gene	erythropoiesis|nmod|START_ENTITY stimulation|nmod|erythropoiesis serum|nmod|stimulation serum|nsubj|END_ENTITY	In vitro stimulation of erythropoiesis by stem_cell_factor alone in myelodysplastic_syndrome patients with elevated endogenous erythropoietin serum levels .
26727404	0	stem_cell_factor	8,24	fibroblast_growth_factor_2	88,114	stem cell factor	fibroblast growth factor 2	396028(Tax:9031)	396413(Tax:9031)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|nmod|END_ENTITY	Chicken stem_cell_factor enhances primordial germ cell proliferation cooperatively with fibroblast_growth_factor_2 .
10770625	0	stem_cell_factor	132,148	granulocyte-macrophage_colony-stimulating_factor	149,197	stem cell factor	granulocyte-macrophage colony-stimulating factor	17311(Tax:10090)	12981(Tax:10090)	Gene	Gene	transfer|compound|START_ENTITY transfer|amod|END_ENTITY	Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting_cells through stem_cell_factor / granulocyte-macrophage_colony-stimulating_factor gene transfer .
15019293	0	stem_cell_factor	113,129	granulocyte-macrophage_colony-stimulating_factor	63,111	stem cell factor	granulocyte-macrophage colony-stimulating factor	17311(Tax:10090)	12981(Tax:10090)	Gene	Gene	hematopoietic_progenitor_cells|nsubj|START_ENTITY hematopoietic_progenitor_cells|nmod|induction induction|nmod|differentiation differentiation|nmod|END_ENTITY	In vitro induction of inhibitory macrophage differentiation by granulocyte-macrophage_colony-stimulating_factor , stem_cell_factor and interferon-gamma from lineage phenotypes-negative c-kit-positive murine hematopoietic_progenitor_cells .
7532035	0	stem_cell_factor	106,122	granulocyte-macrophage_colony-stimulating_factor	171,219	stem cell factor	granulocyte-macrophage colony-stimulating factor	4254	1437	Gene	Gene	abrogates|compound|START_ENTITY expressing|dobj|abrogates line|acl|expressing interaction|nmod|line cytokine|nsubj|interaction cytokine|xcomp|dependency dependency|nmod|production production|amod|END_ENTITY	Cell-to-cell interaction of cytokine-dependent myeloblastic line constitutively expressing membrane-bound stem_cell_factor abrogates cytokine dependency partially through granulocyte-macrophage_colony-stimulating_factor production .
7693027	0	stem_cell_factor	24,40	granulocyte-macrophage_colony-stimulating_factor	77,125	stem cell factor	granulocyte-macrophage colony-stimulating factor	4254	1437	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of c-kit_ligand -LRB- stem_cell_factor -RRB- in combination with interleukin-5 , granulocyte-macrophage_colony-stimulating_factor , and interleukin-3 , on eosinophil lineage .
12130497	0	stem_cell_factor	186,202	granulocyte_colony-stimulating_factor	128,165	stem cell factor	granulocyte colony-stimulating factor	4254	1440	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nmod|granulocyte_colony-stimulating_factor granulocyte_colony-stimulating_factor|nmod|END_ENTITY	Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte_colony-stimulating_factor alone versus granulocyte_colony-stimulating_factor in combination with stem_cell_factor .
12130497	0	stem_cell_factor	186,202	granulocyte_colony-stimulating_factor	77,114	stem cell factor	granulocyte colony-stimulating factor	4254	1440	Gene	Gene	mobilized|nmod|START_ENTITY mobilized|nmod|END_ENTITY	Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte_colony-stimulating_factor alone versus granulocyte_colony-stimulating_factor in combination with stem_cell_factor .
12634728	0	stem_cell_factor	83,99	granulocyte_colony-stimulating_factor	166,203	stem cell factor	granulocyte colony-stimulating factor	4254	1440	Gene	Gene	ancestim|appos|START_ENTITY ancestim|nmod|patients patients|acl:relcl|failed failed|nmod|filgrastim filgrastim|appos|END_ENTITY	Successful mobilization of peripheral blood stem cells after addition of ancestim -LRB- stem_cell_factor -RRB- in patients who had failed a prior mobilization with filgrastim -LRB- granulocyte_colony-stimulating_factor -RRB- alone or with chemotherapy plus filgrastim .
16787870	0	stem_cell_factor	40,56	granulocyte_colony-stimulating_factor	71,108	stem cell factor	granulocyte colony-stimulating factor	4254	1440	Gene	Gene	administration|nmod|START_ENTITY response|nmod|administration combined|nsubj|response combined|nmod|END_ENTITY	Stable response after administration of stem_cell_factor combined with granulocyte_colony-stimulating_factor in aplastic_anemia .
1714329	0	stem_cell_factor	44,60	granulocyte_colony-stimulating_factor	145,182	stem cell factor	granulocyte colony-stimulating factor	17311(Tax:10090)	1440	Gene	Gene	hematopoiesis|nmod|START_ENTITY effects|nmod|hematopoiesis administered|nsubj|effects administered|nmod|END_ENTITY	The effects on hematopoiesis of recombinant stem_cell_factor -LRB- ligand for c-kit -RRB- administered in vivo to mice either alone or in combination with granulocyte_colony-stimulating_factor .
7519076	0	stem_cell_factor	91,107	granulocyte_colony-stimulating_factor	113,150	stem cell factor	granulocyte colony-stimulating factor	17311(Tax:10090)	1440	Gene	Gene	combination|nmod|START_ENTITY mice|nmod|combination cells|nmod|mice Mobilization|nmod|cells Mobilization|nmod|END_ENTITY	Mobilization of long-term hematopoietic reconstituting cells in mice by the combination of stem_cell_factor plus granulocyte_colony-stimulating_factor .
7691233	0	stem_cell_factor	16,32	granulocyte_colony-stimulating_factor	67,104	stem cell factor	granulocyte colony-stimulating factor	60427(Tax:10116)	1440	Gene	Gene	synergizes|nsubj|START_ENTITY synergizes|nmod|END_ENTITY	Recombinant rat stem_cell_factor synergizes with recombinant human granulocyte_colony-stimulating_factor in vivo in mice to mobilize peripheral blood progenitor cells that have enhanced repopulating potential .
9195779	0	stem_cell_factor	98,114	interleukin-11	11,25	stem cell factor	interleukin-11	60427(Tax:10116)	171040(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interleukin-11 on carboplatin-induced thrombocytopenia in rats and in combination with stem_cell_factor .
1710148	0	stem_cell_factor	18,34	interleukin-3	185,198	stem cell factor	interleukin-3	4254	3562	Gene	Gene	enhances|nsubj|START_ENTITY enhances|parataxis|cultured cultured|advcl|END_ENTITY	Recombinant human stem_cell_factor enhances the formation of colonies by CD34 + and CD34 + lin - cells , and the generation of colony-forming cell progeny from CD34 + lin - cells cultured with interleukin-3 , granulocyte_colony-stimulating_factor , or granulocyte-macrophage_colony-stimulating_factor .
7507298	0	stem_cell_factor	59,75	interleukin-3	11,24	stem cell factor	interleukin-3	17311(Tax:10090)	16187(Tax:10090)	Gene	Gene	c-kit_ligand|appos|START_ENTITY END_ENTITY|nmod|c-kit_ligand	Effects of interleukin-3 with or without the c-kit_ligand , stem_cell_factor , on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro .
7514543	0	stem_cell_factor	22,38	interleukin-3	44,57	stem cell factor	interleukin-3	17311(Tax:10090)	16187(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Synergistic effect of stem_cell_factor with interleukin-3 or granulocyte-macrophage_colony-stimulating_factor on the proliferation of murine primitive hematopoietic progenitors .
7522690	0	stem_cell_factor	14,30	interleukin-3	74,87	stem cell factor	interleukin-3	4254	3562	Gene	Gene	formation|compound|START_ENTITY Inhibition|nmod|formation Inhibition|nmod|END_ENTITY	Inhibition of stem_cell_factor dependent formation of human mast cells by interleukin-3 and interleukin-4 .
7694867	0	stem_cell_factor	117,133	interleukin-3	135,148	stem cell factor	interleukin-3	4254	3562	Gene	Gene	cells|nmod|START_ENTITY proliferation|dep|cells proliferation|amod|END_ENTITY	Interleukin-11 stimulates the proliferation of human hematopoietic CD34 + and CD34 + CD33-DR - cells and synergizes with stem_cell_factor , interleukin-3 , and granulocyte-macrophage_colony-stimulating_factor .
10394106	0	stem_cell_factor	87,103	interleukin_13	53,67	stem cell factor	interleukin 13	4254	3596	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|nmod|presence	Cord-blood-derived human cultured mast cells produce interleukin_13 in the presence of stem_cell_factor .
1379243	0	stem_cell_factor	90,106	kit	35,38	stem cell factor	kit	4254	3815	Gene	Gene	Dimerization|nmod|START_ENTITY Dimerization|nmod|receptor receptor|compound|END_ENTITY	Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem_cell_factor .
10819761	0	stem_cell_factor	36,52	kit_ligand	25,35	stem cell factor	kit ligand	4254	4254	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression and action of kit_ligand / stem_cell_factor in normal human and bovine ovarian_surface_epithelium and ovarian_cancer .
25683915	0	stem_cell_factor	112,128	miR-34c	13,20	stem cell factor	miR-34c	60427(Tax:10116)	100314014(Tax:10116)	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	The microRNA miR-34c inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia by targeting stem_cell_factor .
7544805	0	stem_cell_factor	108,124	phospholipase_A2	48,64	stem cell factor	phospholipase A2	17311(Tax:10090)	18780(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Regulation of arachidonic_acid , eicosanoid , and phospholipase_A2 levels in murine mast cells by recombinant stem_cell_factor .
7535148	0	stem_cell_factor	26,42	steel_factor	12,24	stem cell factor	steel factor	17311(Tax:10090)	17311(Tax:10090)	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of steel_factor -LRB- stem_cell_factor -RRB- isoforms in the hematopoietic microenvironment .
7789184	0	stem_cell_tyrosine_kinase-1	26,53	FLT3	60,64	stem cell tyrosine kinase-1	FLT3	2322	2322	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Localization of the human stem_cell_tyrosine_kinase-1 gene -LRB- FLT3 -RRB- to 13q12 -- > q13 .
26738774	0	stem_cell_zinc_finger_1	4,27	ZNF589	35,41	stem cell zinc finger 1	ZNF589	51385	51385	Gene	Gene	protein|compound|START_ENTITY protein|compound|END_ENTITY	The stem_cell_zinc_finger_1 -LRB- SZF1 -RRB- / ZNF589 protein has a human-specific evolutionary nucleotide DNA change and acts as a regulator of cell viability in the hematopoietic system .
115376	0	steroid-binding_protein	39,62	SBP	64,67	steroid-binding protein	SBP	8991	8991	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Immunochemical characterization of sex steroid-binding_protein -LRB- SBP -RRB- of human sera .
4041533	0	steroid-binding_protein	62,85	SBP	87,90	steroid-binding protein	SBP	100009224(Tax:9986)	100009224(Tax:9986)	Gene	Gene	localization|nmod|START_ENTITY studies|nmod|localization studies|appos|END_ENTITY	Light and electron microscopic studies on the localization of steroid-binding_protein -LRB- SBP -RRB- in rabbit spermatozoa .
23449887	0	steroid-sensitive_gene-1	18,42	Ccdc80	43,49	steroid-sensitive gene-1	Ccdc80	151887	151887	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of steroid-sensitive_gene-1 / Ccdc80 as a JAK2-binding protein .
1986928	0	steroid_17_alpha-hydroxylase	61,89	Transforming_growth_factor_beta_1	0,33	steroid 17 alpha-hydroxylase	Transforming growth factor beta 1	281739(Tax:9913)	282089(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 is a negative regulator of steroid_17_alpha-hydroxylase expression in bovine adrenocortical cells .
2249999	0	steroid_21-hydroxylase	56,78	CYP21	85,90	steroid 21-hydroxylase	CYP21	1589	1589	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Determination of functional effects of mutations in the steroid_21-hydroxylase gene -LRB- CYP21 -RRB- using recombinant vaccinia_virus .
19272182	0	steroid_21-hydroxylase	35,57	CYP21A2	64,71	steroid 21-hydroxylase	CYP21A2	1589	1589	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel 9-bp insertion detected in steroid_21-hydroxylase gene -LRB- CYP21A2 -RRB- : prediction of its structural and functional implications by computational methods .
23342490	0	steroid_21-hydroxylase	8,30	CYP21A2	36,43	steroid 21-hydroxylase	CYP21A2	1589	1589	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|compound|END_ENTITY	-LSB- Unique steroid_21-hydroxylase gene CYP21A2 polymorphism in patients with hyperandrogenism signs -RSB- .
25210767	0	steroid_21-hydroxylase	37,59	CYP21A2	66,73	steroid 21-hydroxylase	CYP21A2	1589	1589	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variants of the human steroid_21-hydroxylase gene -LRB- CYP21A2 -RRB- are related to differences in circulating hormone levels .
8380897	0	steroid_21-hydroxylase	77,99	NGFI-B	28,34	steroid 21-hydroxylase	NGFI-B	13079(Tax:10090)	15370(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The orphan nuclear receptor NGFI-B regulates expression of the gene encoding steroid_21-hydroxylase .
1937474	0	steroid_21-hydroxylase	38,60	P450c21B	64,72	steroid 21-hydroxylase	P450c21B	1589	1589	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Substitution of Ile-172_to_Asn in the steroid_21-hydroxylase B -LRB- P450c21B -RRB- gene in a Finnish patient with the simple virilizing form of congenital_adrenal_hyperplasia .
16018939	0	steroid_5-alpha_reductase_type_II	42,75	SRD5A2	77,83	steroid 5-alpha reductase type II	SRD5A2	6716	6716	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Associations between polymorphisms in the steroid_5-alpha_reductase_type_II -LRB- SRD5A2 -RRB- gene and benign_prostatic_hyperplasia and prostate_cancer .
11196450	0	steroid_acute_regulatory	60,84	StAR	86,90	steroid acute regulatory	StAR	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Properties of an adrenal medullary protein immunorelated to steroid_acute_regulatory -LRB- StAR -RRB- protein .
21205914	0	steroid_and_xenobiotic_X_receptor	85,118	Cyp3a11	64,71	steroid and xenobiotic X receptor	Cyp3a11	18171(Tax:10090)	13112(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid_and_xenobiotic_X_receptor humanized mice .
23562850	0	steroid_and_xenobiotic_receptor	74,105	multidrug_resistance_1	109,131	steroid and xenobiotic receptor	multidrug resistance 1	8856	5243	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Interaction of silencing mediator for retinoid and thyroid receptors with steroid_and_xenobiotic_receptor on multidrug_resistance_1 promoter .
16397270	0	steroid_and_xenobiotic_receptor	18,49	organic_anion_transporting_polypeptide-A	80,120	steroid and xenobiotic receptor	organic anion transporting polypeptide-A	8856	6579	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the steroid_and_xenobiotic_receptor and its possible target gene , organic_anion_transporting_polypeptide-A , in human breast_carcinoma .
16144941	0	steroid_and_xenobiotic_receptor	18,49	pregnane_X_receptor	57,76	steroid and xenobiotic receptor	pregnane X receptor	8856	8856	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of the steroid_and_xenobiotic_receptor -LRB- human pregnane_X_receptor -RRB- by nontaxane microtubule-stabilizing agents .
15634719	0	steroid_hormone-binding_globulin	36,68	SHBG	70,74	steroid hormone-binding globulin	SHBG	6462	6462	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Common genetic variation in the sex steroid_hormone-binding_globulin -LRB- SHBG -RRB- gene and circulating shbg levels among postmenopausal women : the Multiethnic Cohort .
20219889	0	steroid_receptor_RNA_activator	94,124	SRA	126,129	steroid receptor RNA activator	SRA	10011	10011	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Research resource : expression profiling reveals unexpected targets and functions of the human steroid_receptor_RNA_activator -LRB- SRA -RRB- gene .
11196413	0	steroid_receptor_coactivator-1	30,60	SRC-1	62,67	steroid receptor coactivator-1	SRC-1	313929(Tax:10116)	313929(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of steroid_receptor_coactivator-1 -LRB- SRC-1 -RRB- in glucocorticoid action .
9506940	0	steroid_receptor_coactivator-1	58,88	SRC-1	90,95	steroid receptor coactivator-1	SRC-1	17977(Tax:10090)	17977(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Partial hormone resistance in mice with disruption of the steroid_receptor_coactivator-1 -LRB- SRC-1 -RRB- gene .
24740565	0	steroid_receptor_coactivator-3	23,53	MicroRNA-195	0,12	steroid receptor coactivator-3	MicroRNA-195	17979(Tax:10090)	406971	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	MicroRNA-195 regulates steroid_receptor_coactivator-3 protein expression in hepatocellular_carcinoma cells .
19716257	0	steroid_receptor_coactivator-3	12,42	SRC-3	44,49	steroid receptor coactivator-3	SRC-3	8202	8202	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of steroid_receptor_coactivator-3 -LRB- SRC-3 -RRB- in human malignant_disease .
2767285	0	steroid_sulfatase	14,31	STS	33,36	steroid sulfatase	STS	412	412	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Study on the steroid_sulfatase -LRB- STS -RRB- activity in normal individuals and patients with abnormal sexual differentiation -RSB- .
20155394	0	steroid_sulfatase	58,75	Sts	77,80	steroid sulfatase	Sts	20905(Tax:10090)	20905(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Brain pathways mediating the pro-aggressive effect of the steroid_sulfatase -LRB- Sts -RRB- gene .
9658401	0	steroidogenic_acute_regulatory	52,82	Atrial_natriuretic_peptide	0,26	steroidogenic acute regulatory	Atrial natriuretic peptide	281507(Tax:9913)	281355(Tax:9913)	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Atrial_natriuretic_peptide inhibits calcium-induced steroidogenic_acute_regulatory protein gene transcription in adrenal_glomerulosa cells .
12580761	0	steroidogenic_acute_regulatory	30,60	Interleukin-1alpha	0,18	steroidogenic acute regulatory	Interleukin-1alpha	25557(Tax:10116)	24493(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-1alpha stimulates steroidogenic_acute_regulatory protein expression via p38 MAP kinase in immature rat Leydig cells .
19179481	0	steroidogenic_acute_regulatory	49,79	STAR	81,85	steroidogenic acute regulatory	STAR	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	cAMP-dependent posttranscriptional regulation of steroidogenic_acute_regulatory -LRB- STAR -RRB- protein by the zinc finger protein ZFP36L1/TIS11b .
10026215	1	steroidogenic_acute_regulatory	115,145	StAR	147,151	steroidogenic acute regulatory	StAR	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Involvement of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein .
10220047	0	steroidogenic_acute_regulatory	19,49	StAR	51,55	steroidogenic acute regulatory	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Down-regulation of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in rat Leydig cells : implications for regulation of testosterone production during aging .
10919257	0	steroidogenic_acute_regulatory	66,96	StAR	98,102	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Interactive stimulation by luteinizing hormone and insulin of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein and 17alpha-hydroxylase/17 ,20 - lyase -LRB- CYP17 -RRB- genes in porcine theca cells .
10940480	0	steroidogenic_acute_regulatory	29,59	StAR	61,65	steroidogenic acute regulatory	StAR	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Expression of adrenocortical steroidogenic_acute_regulatory -LRB- StAR -RRB- protein is influenced by chromaffin cells .
11054639	0	steroidogenic_acute_regulatory	71,101	StAR	103,107	steroidogenic acute regulatory	StAR	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic_acute_regulatory -LRB- StAR -RRB- gene .
11410589	0	steroidogenic_acute_regulatory	80,110	StAR	112,116	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	ERKs regulate cyclic_AMP-induced steroid synthesis through transcription of the steroidogenic_acute_regulatory -LRB- StAR -RRB- gene .
11911955	0	steroidogenic_acute_regulatory	38,68	StAR	70,74	steroidogenic acute regulatory	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional repression of the rat steroidogenic_acute_regulatory -LRB- StAR -RRB- protein gene by the AP-1 family member c-Fos .
12810543	0	steroidogenic_acute_regulatory	79,109	StAR	111,115	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic_acute_regulatory -LRB- StAR -RRB- protein and steroidogenesis .
20416921	0	steroidogenic_acute_regulatory	14,44	StAR	54,58	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY Expression|nmod|protein Expression|appos|END_ENTITY	Expression of steroidogenic_acute_regulatory protein -LRB- StAR -RRB- in male American bullfrog -LRB- Rana catesbeiana -RRB- and preliminary evaluation of the response to TNT .
21153110	0	steroidogenic_acute_regulatory	26,56	StAR	58,62	steroidogenic acute regulatory	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Prostaglandin_F2a reduces steroidogenic_acute_regulatory -LRB- StAR -RRB- protein messenger ribonucleic acid expression in the rat ovary .
21153282	0	steroidogenic_acute_regulatory	23,53	StAR	55,59	steroidogenic acute regulatory	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Hormonal regulation of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein messenger ribonucleic acid expression in the rat ovary .
23415713	0	steroidogenic_acute_regulatory	24,54	StAR	56,60	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression and roles of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in ` non-classical ' , extra-adrenal and extra-gonadal cells and tissues .
7548191	0	steroidogenic_acute_regulatory	10,40	StAR	42,46	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human steroidogenic_acute_regulatory -LRB- StAR -RRB- gene is expressed in the urogenital system and encodes a mitochondrial polypeptide .
7588386	0	steroidogenic_acute_regulatory	18,48	StAR	50,54	steroidogenic acute regulatory	StAR	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expression of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein : a novel LH-induced mitochondrial protein required for the acute regulation of steroidogenesis in mouse Leydig_tumor cells .
8660356	0	steroidogenic_acute_regulatory	32,62	StAR	64,68	steroidogenic acute regulatory	StAR	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Regulation of expression of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein by ACTH in bovine adrenal_fasciculata cells .
8828518	0	steroidogenic_acute_regulatory	72,102	StAR	104,108	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in Leydig cells .
8969904	0	steroidogenic_acute_regulatory	93,123	StAR	125,129	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	ATP and a mitochondrial electrochemical gradient are required for functional activity of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in isolated mitochondria .
8969905	0	steroidogenic_acute_regulatory	47,77	StAR	79,83	steroidogenic acute regulatory	StAR	6770	6770	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Adrenocorticotropin regulates the level of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein mRNA in hamster adrenals .
9622308	0	steroidogenic_acute_regulatory	102,132	StAR	134,138	steroidogenic acute regulatory	StAR	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Possible involvement of calcium/calmodulin-dependent protein kinase in ACTH-induced expression of the steroidogenic_acute_regulatory -LRB- StAR -RRB- protein in bovine adrenal_fasciculata cells .
11162896	0	steroidogenic_acute_regulatory	41,71	Transforming_growth_factor_beta	0,31	steroidogenic acute regulatory	Transforming growth factor beta	6770	7040	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor_beta inhibits steroidogenic_acute_regulatory -LRB- StAR -RRB- protein expression in human ovarian thecal cells .
11861536	0	steroidogenic_acute_regulatory	18,48	Yin_Yang_1	98,108	steroidogenic acute regulatory	Yin Yang 1	25557(Tax:10116)	24919(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY Repression|nmod|gene Repression|nmod|END_ENTITY	Repression of the steroidogenic_acute_regulatory gene by the multifunctional transcription factor Yin_Yang_1 .
11595506	0	steroidogenic_acute_regulatory	56,86	arylhydrocarbon_receptor	18,42	steroidogenic acute regulatory	arylhydrocarbon receptor	6770	196	Gene	Gene	activity|amod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	The effect of the arylhydrocarbon_receptor on the human steroidogenic_acute_regulatory gene promoter activity .
12790807	0	steroidogenic_acute_regulatory	40,70	cAMP_response-element_binding_protein	91,128	steroidogenic acute regulatory	cAMP response-element binding protein	20845(Tax:10090)	12912(Tax:10090)	Gene	Gene	START_ENTITY|nmod|factor factor|amod|END_ENTITY	Transcriptional regulation of the mouse steroidogenic_acute_regulatory protein gene by the cAMP_response-element_binding_protein and steroidogenic factor 1 .
10687849	0	steroidogenic_acute_regulatory	219,249	stAR	251,255	steroidogenic acute regulatory	stAR	6770	6770	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Mechanisms underlying the steroidogenic synergy of insulin and luteinizing hormone in porcine granulosa cells : joint amplification of pivotal sterol-regulatory genes encoding the low-density_lipoprotein _ -LRB- LDL -RRB- _ receptor , steroidogenic_acute_regulatory -LRB- stAR -RRB- protein and cytochrome P450 side-chain cleavage -LRB- P450scc -RRB- enzyme .
19325001	0	steroidogenic_acute_regulatory	64,94	thromboxane_A2_receptor	19,42	steroidogenic acute regulatory	thromboxane A2 receptor	20845(Tax:10090)	21390(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression Involvement|nmod|regulation Involvement|nmod|END_ENTITY	Involvement of the thromboxane_A2_receptor in the regulation of steroidogenic_acute_regulatory gene expression in murine Leydig cells .
17452987	0	steroidogenic_acute_regulatory_protein	71,109	ERK1/2	27,33	steroidogenic acute regulatory protein	ERK1/2	6770	5595;5594	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|compound|END_ENTITY	Human adipocytes induce an ERK1/2 MAP kinases-mediated upregulation of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- and an angiotensin_II-sensitization in human adrenocortical cells .
21719703	0	steroidogenic_acute_regulatory_protein	185,223	Gonadotropin-regulated_testicular_RNA_helicase	0,46	steroidogenic acute regulatory protein	Gonadotropin-regulated testicular RNA helicase	20845(Tax:10090)	30959(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Gonadotropin-regulated_testicular_RNA_helicase -LRB- GRTH/DDX25 -RRB- , a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells : central role of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- .
20421306	0	steroidogenic_acute_regulatory_protein	63,101	Group_X_secretory_phospholipase_A2	0,34	steroidogenic acute regulatory protein	Group X secretory phospholipase A2	20845(Tax:10090)	26565(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Group_X_secretory_phospholipase_A2 regulates the expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in mouse adrenal glands .
10098503	0	steroidogenic_acute_regulatory_protein	25,63	Growth_hormone	0,14	steroidogenic acute regulatory protein	Growth hormone	25557(Tax:10116)	81668(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Growth_hormone regulates steroidogenic_acute_regulatory_protein expression and steroidogenesis in Leydig cell progenitors .
15181096	0	steroidogenic_acute_regulatory_protein	53,91	Liver_receptor_homolog-1	0,24	steroidogenic acute regulatory protein	Liver receptor homolog-1	6770	2494	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Liver_receptor_homolog-1 regulates the expression of steroidogenic_acute_regulatory_protein in human granulosa cells .
11172811	0	steroidogenic_acute_regulatory_protein	60,98	MG132	25,30	steroidogenic acute regulatory protein	MG132	6770	875581(Tax:243273)	Gene	Gene	accumulation|nmod|START_ENTITY promotes|dobj|accumulation promotes|nsubj|END_ENTITY	The proteasome inhibitor MG132 promotes accumulation of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- and steroidogenesis .
16740656	0	steroidogenic_acute_regulatory_protein	45,83	SNF2L	29,34	steroidogenic acute regulatory protein	SNF2L	6770	6594	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The imitation_switch protein SNF2L regulates steroidogenic_acute_regulatory_protein expression during terminal differentiation of ovarian granulosa cells .
16155961	0	steroidogenic_acute_regulatory_protein	27,65	STAR	67,71	steroidogenic acute regulatory protein	STAR	396597(Tax:9823)	396597(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression analysis of the steroidogenic_acute_regulatory_protein -LRB- STAR -RRB- gene in developing porcine conceptuses .
22575868	0	steroidogenic_acute_regulatory_protein	51,89	STARD1	91,97	steroidogenic acute regulatory protein	STARD1	6770	6770	Gene	Gene	inhibitors|nmod|START_ENTITY Identification|nmod|inhibitors Identification|appos|END_ENTITY	Identification of small-molecule inhibitors of the steroidogenic_acute_regulatory_protein -LRB- STARD1 -RRB- by structure-based design .
10364248	0	steroidogenic_acute_regulatory_protein	90,128	StAR	130,134	steroidogenic acute regulatory protein	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	CCAAT enhancer-binding protein beta and GATA-4 binding regions within the promoter of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene are required for transcription in rat ovarian cells .
10473624	0	steroidogenic_acute_regulatory_protein	65,103	StAR	105,109	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	CCAAT/enhancer-binding _ proteins regulate expression of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene .
10541561	0	steroidogenic_acute_regulatory_protein	118,156	StAR	158,162	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Insulin and insulin-like growth factor-I and - II modulate human granulosa-lutein cell steroidogenesis : enhancement of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- expression .
10954035	0	steroidogenic_acute_regulatory_protein	14,52	StAR	54,58	steroidogenic acute regulatory protein	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in rat granulosa cells .
11196424	0	steroidogenic_acute_regulatory_protein	54,92	StAR	94,98	steroidogenic acute regulatory protein	StAR	443122(Tax:9940)	443122(Tax:9940)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	N-proopiomelanocortin -LRB- 1-77 -RRB- suppresses expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- mRNA in the adrenal gland of the fetal sheep .
16682116	0	steroidogenic_acute_regulatory_protein	34,72	StAR	74,78	steroidogenic acute regulatory protein	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : GATA-4 and CCAAT/enhancer-binding _ protein_beta confer synergistic responsiveness in hormone-treated rat granulosa and HEK293 cell models .
17196197	0	steroidogenic_acute_regulatory_protein	27,65	StAR	67,71	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Hormonal regulation of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in gonadal tissues of the Atlantic croaker -LRB- Micropogonias undulatus -RRB- .
21647419	0	steroidogenic_acute_regulatory_protein	32,70	StAR	26,30	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of novel StAR -LRB- steroidogenic_acute_regulatory_protein -RRB- mutations causing non-classic lipoid_adrenal_hyperplasia .
25786521	0	steroidogenic_acute_regulatory_protein	42,80	StAR	82,86	steroidogenic acute regulatory protein	StAR	20845(Tax:10090)	20845(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cadmium up-regulates transcription of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene through phosphorylated CREB rather than SF-1 in K28 cells .
26100237	0	steroidogenic_acute_regulatory_protein	39,77	StAR	79,83	steroidogenic acute regulatory protein	StAR	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lysosomes are involved in induction of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene expression and progesterone synthesis through low-density lipoprotein in cultured bovine granulosa cells .
7547998	0	steroidogenic_acute_regulatory_protein	23,61	StAR	63,67	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Structure of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : StAR stimulates mitochondrial cholesterol 27-hydroxylase activity .
8573184	0	steroidogenic_acute_regulatory_protein	12,50	StAR	52,56	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in steroidogenesis .
8703908	0	steroidogenic_acute_regulatory_protein	64,102	StAR	104,108	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Steroidogenic_factor_1-dependent promoter activity of the human steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene .
8923870	0	steroidogenic_acute_regulatory_protein	14,52	StAR	54,58	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in the human ovary .
9029708	0	steroidogenic_acute_regulatory_protein	32,70	StAR	72,76	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regulation of expression of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene : a central role for steroidogenic_factor_1 .
9077535	1	steroidogenic_acute_regulatory_protein	169,207	StAR	209,213	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene .
9097960	0	steroidogenic_acute_regulatory_protein	16,54	StAR	56,60	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- gene in Japanese patients with congenital_lipoid_adrenal_hyperplasia .
9328229	0	steroidogenic_acute_regulatory_protein	69,107	StAR	109,113	steroidogenic acute regulatory protein	StAR	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Molecular cloning , characterization and cellular distribution of rat steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in the ovary .
9405483	0	steroidogenic_acute_regulatory_protein	19,57	StAR	59,63	steroidogenic acute regulatory protein	StAR	6770	6770	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- modulates its steroidogenic activity .
9888538	0	steroidogenic_acute_regulatory_protein	18,56	StAR	58,62	steroidogenic acute regulatory protein	StAR	281507(Tax:9913)	281507(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- in bovine adrenocortical cells .
17431006	0	steroidogenic_acute_regulatory_protein	35,73	clock	10,15	steroidogenic acute regulatory protein	clock	395421(Tax:9031)	373991(Tax:9031)	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Circadian clock gene regulation of steroidogenic_acute_regulatory_protein gene expression in preovulatory ovarian follicles .
8536719	0	steroidogenic_acute_regulatory_protein	159,197	protein_kinase_A	110,126	steroidogenic acute regulatory protein	protein kinase A	25557(Tax:10116)	25636(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|compound|END_ENTITY	Diethylumbelliferyl_phosphate inhibits steroidogenesis by interfering with a long-lived factor acting between protein_kinase_A activation and induction of the steroidogenic_acute_regulatory_protein -LRB- StAR -RRB- .
11695844	0	steroidogenic_acute_regulatory_protein	96,134	star	136,140	steroidogenic acute regulatory protein	star	25557(Tax:10116)	25557(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Inhibition of steroidogenesis in Leydig cells by exogenous nitric_oxide occurs independently of steroidogenic_acute_regulatory_protein -LRB- star -RRB- mRNA .
23219870	0	steroidogenic_factor-1	22,44	NR5A1	46,51	steroidogenic factor-1	NR5A1	2516	2516	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Distinct functions of steroidogenic_factor-1 -LRB- NR5A1 -RRB- in the nucleus and the centrosome .
16613990	0	steroidogenic_factor_1	53,75	Isl-1	29,34	steroidogenic factor 1	Isl-1	2516	3670	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	The LIM-homeodomain proteins Isl-1 and Lhx3 act with steroidogenic_factor_1 to enhance gonadotrope-specific activity of the gonadotropin-releasing_hormone_receptor gene promoter .
9468515	0	steroidogenic_factor_1	40,62	P450scc	24,31	steroidogenic factor 1	P450scc	2516	1583	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of the human P450scc gene by steroidogenic_factor_1 is mediated by CBP/p300 .
11328853	0	steroidogenic_factor_1	72,94	follicle-stimulating_hormone_receptor	22,59	steroidogenic factor 1	follicle-stimulating hormone receptor	117855(Tax:10116)	25449(Tax:10116)	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Activation of the rat follicle-stimulating_hormone_receptor promoter by steroidogenic_factor_1 is blocked by protein kinase a and requires upstream stimulatory factor binding to a proximal E box element .
12048207	0	sterol-regulatory_element-binding_protein-1c	12,56	SREBP-1C	58,66	sterol-regulatory element-binding protein-1c	SREBP-1C	6720	6720	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Insulin and sterol-regulatory_element-binding_protein-1c -LRB- SREBP-1C -RRB- regulation of gene expression in 3T3-L1 adipocytes .
10051404	0	sterol_12alpha-hydroxylase	44,70	CYP8B1	77,83	sterol 12alpha-hydroxylase	CYP8B1	1582	1582	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and chromosomal assignment of the sterol_12alpha-hydroxylase gene -LRB- CYP8B1 -RRB- in human and mouse : eukaryotic cytochrome_P-450 gene devoid of introns .
11535594	0	sterol_12alpha-hydroxylase	40,66	CYP8B1	73,79	sterol 12alpha-hydroxylase	CYP8B1	1582	1582	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the human sterol_12alpha-hydroxylase gene -LRB- CYP8B1 -RRB- : roles of heaptocyte nuclear factor 4alpha in mediating bile_acid repression .
11574686	0	sterol_12alpha-hydroxylase	15,41	short_heterodimer_partner	63,88	sterol 12alpha-hydroxylase	short heterodimer partner	1582	8431	Gene	Gene	transcription|amod|START_ENTITY transcription|nmod|END_ENTITY	Suppression of sterol_12alpha-hydroxylase transcription by the short_heterodimer_partner : insights into the repression mechanism .
10788789	0	sterol_14alpha-demethylase	21,47	CYP51	49,54	sterol 14alpha-demethylase	CYP51	403334(Tax:9823)	403334(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure of the pig sterol_14alpha-demethylase -LRB- CYP51 -RRB- gene and its expression in the testis and other tissues .
19149177	0	sterol_14alpha-demethylase	13,39	CYP51	41,46	sterol 14alpha-demethylase	CYP51	1595	1595	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Advances in sterol_14alpha-demethylase -LRB- CYP51 -RRB- -RSB- .
10519880	0	sterol_27-hydroxylase	16,37	CYP27	44,49	sterol 27-hydroxylase	CYP27	1593	1593	Gene	Gene	results|amod|START_ENTITY results|appos|END_ENTITY	Mutation of the sterol_27-hydroxylase gene -LRB- CYP27 -RRB- results in truncation of mRNA expressed in leucocytes in a Japanese family with cerebrotendinous_xanthomatosis .
11395030	0	sterol_27-hydroxylase	40,61	CYP27	68,73	sterol 27-hydroxylase	CYP27	1593	1593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of the human sterol_27-hydroxylase gene -LRB- CYP27 -RRB- and promoter mapping .
11486904	0	sterol_27-hydroxylase	88,109	CYP27	116,121	sterol 27-hydroxylase	CYP27	1593	1593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frontal lobe dementia with abnormal cholesterol metabolism and heterozygous mutation in sterol_27-hydroxylase gene -LRB- CYP27 -RRB- .
9790667	0	sterol_27-hydroxylase	34,55	CYP27	62,67	sterol 27-hydroxylase	CYP27	1593	1593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel Arg362Ser mutation in the sterol_27-hydroxylase gene -LRB- CYP27 -RRB- : its effects on pre-mRNA splicing and enzyme activity .
16549062	0	sterol_27-hydroxylase	31,52	CYP27A1	54,61	sterol 27-hydroxylase	CYP27A1	1593	1593	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of sterol_27-hydroxylase -LRB- CYP27A1 -RRB- in monkey retina .
9521761	0	sterol_27-hydroxylase	38,59	CYP_27	66,72	sterol 27-hydroxylase	CYP 27	1593	1593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Silent nucleotide substitution in the sterol_27-hydroxylase gene -LRB- CYP_27 -RRB- leads to alternative pre-mRNA splicing by activating a cryptic 5 ' splice site at the mutant codon in cerebrotendinous_xanthomatosis patients .
9548584	0	sterol_27-hydroxylase	37,58	CYP_27	65,71	sterol 27-hydroxylase	CYP 27	1593	1593	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative pre-mRNA splicing of the sterol_27-hydroxylase gene -LRB- CYP_27 -RRB- caused by a G to A mutation at the last nucleotide of exon 6 in a patient with cerebrotendinous_xanthomatosis -LRB- CTX -RRB- .
7488641	0	sterol_carrier_protein-2	81,105	non-specific_lipid_transfer_protein	44,79	sterol carrier protein-2	non-specific lipid transfer protein	25541(Tax:10116)	25541(Tax:10116)	Gene	Gene	localization|dep|START_ENTITY localization|nmod|END_ENTITY	The immunohistochemical localization of the non-specific_lipid_transfer_protein -LRB- sterol_carrier_protein-2 -RRB- in rat small intestine enterocytes .
10585416	0	sterol_carrier_protein-2	75,99	sterol_carrier_protein-x	100,124	sterol carrier protein-2	sterol carrier protein-x	20280(Tax:10090)	20280(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Aberrant oxidation of the cholesterol side chain in bile_acid synthesis of sterol_carrier_protein-2 / sterol_carrier_protein-x knockout mice .
15574183	0	sterol_carrier_protein-2	91,115	sterol_carrier_protein-x	116,140	sterol carrier protein-2	sterol carrier protein-x	20280(Tax:10090)	20280(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Phytanic_acid accumulation is associated with conduction delay and sudden_cardiac_death in sterol_carrier_protein-2 / sterol_carrier_protein-x deficient mice .
9553048	0	sterol_carrier_protein-2	87,111	sterol_carrier_protein-x	112,136	sterol carrier protein-2	sterol carrier protein-x	20280(Tax:10090)	20280(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Defective peroxisomal catabolism of branched fatty_acyl coenzyme A in mice lacking the sterol_carrier_protein-2 / sterol_carrier_protein-x gene function .
10585416	0	sterol_carrier_protein-x	100,124	sterol_carrier_protein-2	75,99	sterol carrier protein-x	sterol carrier protein-2	20280(Tax:10090)	20280(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Aberrant oxidation of the cholesterol side chain in bile_acid synthesis of sterol_carrier_protein-2 / sterol_carrier_protein-x knockout mice .
15574183	0	sterol_carrier_protein-x	116,140	sterol_carrier_protein-2	91,115	sterol carrier protein-x	sterol carrier protein-2	20280(Tax:10090)	20280(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Phytanic_acid accumulation is associated with conduction delay and sudden_cardiac_death in sterol_carrier_protein-2 / sterol_carrier_protein-x deficient mice .
9553048	0	sterol_carrier_protein-x	112,136	sterol_carrier_protein-2	87,111	sterol carrier protein-x	sterol carrier protein-2	20280(Tax:10090)	20280(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Defective peroxisomal catabolism of branched fatty_acyl coenzyme A in mice lacking the sterol_carrier_protein-2 / sterol_carrier_protein-x gene function .
3371541	0	sterol_carrier_protein2	14,37	SCP2	39,43	sterol carrier protein2	SCP2	25541(Tax:10116)	25541(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Regulation of sterol_carrier_protein2 -LRB- SCP2 -RRB- levels in the soluble fraction of rat Leydig cells .
8640304	0	sterol_carrier_protein_2	14,38	SCP2	40,44	sterol carrier protein 2	SCP2	6342	6342	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of sterol_carrier_protein_2 -LRB- SCP2 -RRB- in human adrenocortical tissue .
2628429	0	sterol_carrier_protein_2	52,76	nonspecific_lipid_transfer_protein	16,50	sterol carrier protein 2	nonspecific lipid transfer protein	25541(Tax:10116)	25541(Tax:10116)	Gene	Gene	Biosynthesis|appos|START_ENTITY Biosynthesis|nmod|END_ENTITY	Biosynthesis of nonspecific_lipid_transfer_protein -LRB- sterol_carrier_protein_2 -RRB- on free polyribosomes as a larger precursor in rat liver .
26144236	0	sterol_carrier_protein_type_2	71,100	SCP-2	102,107	sterol carrier protein type 2	SCP-2	6342	6342	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Synthesis , purification and crystallographic studies of the C-terminal sterol_carrier_protein_type_2 -LRB- SCP-2 -RRB- domain of human hydroxysteroid_dehydrogenase-like_protein_2 .
10947952	0	sterol_regulatory-element-binding_protein-1c	19,63	SREBP-1c	65,73	sterol regulatory-element-binding protein-1c	SREBP-1c	78968(Tax:10116)	78968(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Insulin effects on sterol_regulatory-element-binding_protein-1c -LRB- SREBP-1c -RRB- transcriptional activity in rat hepatocytes .
12941932	0	sterol_regulatory_element-binding_protein-1	77,120	Protein-tyrosine_phosphatase_1B	0,31	sterol regulatory element-binding protein-1	Protein-tyrosine phosphatase 1B	78968(Tax:10116)	24697(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Protein-tyrosine_phosphatase_1B as new activator for hepatic lipogenesis via sterol_regulatory_element-binding_protein-1 gene expression .
22511764	0	sterol_regulatory_element-binding_protein-1c	15,59	FoxO1	0,5	sterol regulatory element-binding protein-1c	FoxO1	20787(Tax:10090)	56458(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	FoxO1 inhibits sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene expression via transcription factors Sp1 and SREBP-1c .
11371634	0	sterol_regulatory_element-binding_protein-1c	53,97	SREBP-1c	99,107	sterol regulatory element-binding protein-1c	SREBP-1c	6720	6720	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Unsaturated fatty_acids inhibit transcription of the sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene by antagonizing ligand-dependent activation of the LXR .
22511764	0	sterol_regulatory_element-binding_protein-1c	15,59	Sp1	113,116	sterol regulatory element-binding protein-1c	Sp1	20787(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	FoxO1 inhibits sterol_regulatory_element-binding_protein-1c -LRB- SREBP-1c -RRB- gene expression via transcription factors Sp1 and SREBP-1c .
24993831	0	sterol_regulatory_element-binding_protein-1c	75,119	Srebp-1c	121,129	sterol regulatory element-binding protein-1c	Srebp-1c	20787(Tax:10090)	20787(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hepatic differentiated embryo-chondrocyte-expressed gene 1 -LRB- Dec1 -RRB- inhibits sterol_regulatory_element-binding_protein-1c -LRB- Srebp-1c -RRB- expression and alleviates fatty_liver phenotype .
16806080	0	sterol_regulatory_element-binding_protein-2	14,57	SREBP-2	59,66	sterol regulatory element-binding protein-2	SREBP-2	6721	6721	Gene	Gene	regulation|amod|START_ENTITY regulation|appos|END_ENTITY	Mechanisms of sterol_regulatory_element-binding_protein-2 -LRB- SREBP-2 -RRB- regulation of human prostasin gene expression .
11171976	0	sterol_regulatory_element-binding_protein_1c	14,58	SREBP-1c	60,68	sterol regulatory element-binding protein 1c	SREBP-1c	78968(Tax:10116)	78968(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of sterol_regulatory_element-binding_protein_1c -LRB- SREBP-1c -RRB- mRNA in rat hepatoma cells requires endogenous LXR ligands .
10570913	0	sterol_regulatory_element_binding_protein	55,96	SCAP	134,138	sterol regulatory element binding protein	SCAP	7555	22937	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and chromosomal mapping of the human sterol_regulatory_element_binding_protein -LRB- SREBP -RRB- cleavage-activating protein -LRB- SCAP -RRB- gene .
26601584	0	sterol_regulatory_element_binding_protein_1	26,69	SREBP1	18,24	sterol regulatory element binding protein 1	SREBP1	100860908	100860908	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of SREBP1 -LRB- sterol_regulatory_element_binding_protein_1 -RRB- promotes de novo fatty_acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells .
24972343	0	sterol_regulatory_element_binding_protein_2	108,151	SREBP2	153,159	sterol regulatory element binding protein 2	SREBP2	6721	6721	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Lupin peptides lower low-density lipoprotein -LRB- LDL -RRB- cholesterol through an up-regulation of the LDL_receptor / sterol_regulatory_element_binding_protein_2 -LRB- SREBP2 -RRB- pathway at HepG2 cell line .
20728021	0	sterol_regulatory_element_binding_protein_2	57,100	paraoxonase_1	23,36	sterol regulatory element binding protein 2	paraoxonase 1	6721	5444	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Quercetin up-regulates paraoxonase_1 gene expression via sterol_regulatory_element_binding_protein_2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase_1 promoter in HuH7 liver cells .
20728021	0	sterol_regulatory_element_binding_protein_2	57,100	paraoxonase_1	245,258	sterol regulatory element binding protein 2	paraoxonase 1	6721	5444	Gene	Gene	START_ENTITY|acl:relcl|translocates translocates|advcl|interacts interacts|nmod|sequence sequence|nmod|promoter promoter|amod|END_ENTITY	Quercetin up-regulates paraoxonase_1 gene expression via sterol_regulatory_element_binding_protein_2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase_1 promoter in HuH7 liver cells .
26827839	0	stimulator_of_interferon_gene	23,52	STING	54,59	stimulator of interferon gene	STING	533661(Tax:9913)	533661(Tax:9913)	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	The function of feline stimulator_of_interferon_gene -LRB- STING -RRB- is evolutionarily conserved .
14499607	0	stn-1	4,9	syntrophin	10,20	stn-1	syntrophin	266844(Tax:6239)	181029(Tax:6239)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin .
8786142	0	stomatin	64,72	Epb72	79,84	stomatin	Epb72	13830(Tax:10090)	13830(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and 5 ' - flanking DNA sequence of the murine stomatin gene -LRB- Epb72 -RRB- .
19696025	0	stomatin	39,47	Stomatin-like_protein-1	0,23	stomatin	Stomatin-like protein-1	2040	9399	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Stomatin-like_protein-1 interacts with stomatin and is targeted to late endosomes .
15694024	0	stomatin-like_protein_2	11,34	SLP-2	36,41	stomatin-like protein 2	SLP-2	30968	30968	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Effect of stomatin-like_protein_2 -LRB- SLP-2 -RRB- gene on growth and proliferation of esophageal_squamous_carcinoma cell line TE12 -RSB- .
15631619	0	stoned-B	82,90	intersectin	112,123	stoned-B	intersectin	4379834(Tax:7227)	35378(Tax:7227)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Molecular and genetic characterization of the interactions between the Drosophila stoned-B protein and DAP-160 -LRB- intersectin -RRB- .
11454741	0	stoned_B	6,14	AP-2	30,34	stoned B	AP-2	4379834(Tax:7227)	7020	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Human stoned_B interacts with AP-2 and synaptotagmin and facilitates clathrin-coated vesicle uncoating .
18780375	0	storage_protein_1	31,48	SP1	50,53	storage protein 1	SP1	6667	6667	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of storage_protein_1 -LRB- SP1 -RRB- in differentiated fat body tissues of red hairy caterpillar , Amsacta albistriga Walker .
15646039	0	stratifin	53,62	Insulin	0,7	stratifin	Insulin	2810	3630	Gene	Gene	effect|nmod|START_ENTITY suppresses|dobj|effect suppresses|nsubj|END_ENTITY	Insulin suppresses collagenase stimulatory effect of stratifin in dermal fibroblasts .
8393902	0	stratum_corneum_chymotryptic_enzyme	49,84	proteinase	88,98	stratum corneum chymotryptic enzyme	proteinase	5650	100616101	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Purification and preliminary characterization of stratum_corneum_chymotryptic_enzyme : a proteinase that may be involved in desquamation .
8557667	0	stress-activated_protein_kinase	67,98	mitogen-activated_protein_kinase_phosphatase_1	13,59	stress-activated protein kinase	mitogen-activated protein kinase phosphatase 1	5601	1843	Gene	Gene	pathway|amod|START_ENTITY END_ENTITY|nmod|pathway	Induction of mitogen-activated_protein_kinase_phosphatase_1 by the stress-activated_protein_kinase signaling pathway but not by extracellular_signal-regulated_kinase in fibroblasts .
9305750	0	stress-activated_protein_kinase-1	27,60	SKK4	0,4	stress-activated protein kinase-1	SKK4	5599	5609	Gene	Gene	activator|nmod|START_ENTITY END_ENTITY|appos|activator	SKK4 , a novel activator of stress-activated_protein_kinase-1 -LRB- SAPK1/JNK -RRB- .
11718727	0	stress-activated_protein_kinase-beta	33,69	SCG10	141,146	stress-activated protein kinase-beta	SCG10	5602	11075	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	c-Jun_N-terminal_kinase-3 -LRB- JNK3 -RRB- / stress-activated_protein_kinase-beta -LRB- SAPKbeta -RRB- binds and phosphorylates the neuronal microtubule regulator SCG10 .
8598210	0	stress-activated_protein_kinases	53,85	CD40	14,18	stress-activated protein kinases	CD40	5601	958	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Cross-linking CD40 on B cells preferentially induces stress-activated_protein_kinases rather than mitogen-activated protein kinases .
11557757	0	stress-induced_protein	49,71	SIP	73,76	stress-induced protein	SIP	60599(Tax:10090)	60599(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular and functional characterization of the stress-induced_protein -LRB- SIP -RRB- gene and its two transcripts generated by alternative splicing .
24133259	0	stress-inducible_phosphoprotein_1	26,59	prion_protein	4,17	stress-inducible phosphoprotein 1	prion protein	20867(Tax:10090)	19122(Tax:10090)	Gene	Gene	ligand|amod|START_ENTITY ligand|compound|END_ENTITY	The prion_protein ligand , stress-inducible_phosphoprotein_1 , regulates amyloid-b oligomer toxicity .
20615969	0	stress-inducible_protein_1	31,57	Prion_protein	0,13	stress-inducible protein 1	Prion protein	10963	5621	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Prion_protein interaction with stress-inducible_protein_1 enhances neuronal protein synthesis via mTOR .
19760599	0	stress-inducible_protein_1	58,84	prion_protein	28,41	stress-inducible protein 1	prion protein	20867(Tax:10090)	19122(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Developmental expression of prion_protein and its ligands stress-inducible_protein_1 and vitronectin .
20837487	0	stress-inducible_protein_1	111,137	prion_protein	80,93	stress-inducible protein 1	prion protein	10963	5621	Gene	Gene	induced|advcl|START_ENTITY induced|nmod|interaction interaction|compound|END_ENTITY	Role of alpha7_nicotinic_acetylcholine_receptor in calcium signaling induced by prion_protein interaction with stress-inducible_protein_1 .
21608082	0	stress-inducible_protein_1	74,100	prion_protein	110,123	stress-inducible protein 1	prion protein	20867(Tax:10090)	19122(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY self-renewal|nmod|interaction self-renewal|nmod|END_ENTITY	Enhanced neural progenitor/stem cells self-renewal via the interaction of stress-inducible_protein_1 with the prion_protein .
15070962	0	stresscopin	28,39	urocortin_III	14,27	stresscopin	urocortin III	114131	114131	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of urocortin_III / stresscopin in human heart and kidney .
11283016	0	striated_muscle_RING_zinc_finger_protein	14,54	SMT3b	77,82	striated muscle RING zinc finger protein	SMT3b	84676	6613	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	A novel human striated_muscle_RING_zinc_finger_protein , SMRZ , interacts with SMT3b via its RING domain .
7490079	0	striatum-enriched_phosphatase	44,73	STEP	75,79	striatum-enriched phosphatase	STEP	84867	84867	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning of the human homolog of a striatum-enriched_phosphatase -LRB- STEP -RRB- gene and chromosomal mapping of the human and murine loci .
23042661	0	stroke	46,52	CXCL12	7,13	CXCL12	CXCL12	6387	6387	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	Plasma CXCL12 levels as a predictor of future stroke .
15157323	0	stroma_cell_drived_factor_1	23,50	SDF-1	52,57	stroma cell drived factor 1	SDF-1	6387	6387	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	-LSB- Inhibiting effects of stroma_cell_drived_factor_1 -LRB- SDF-1 -RRB- on proliferation of human acute_myelocytic_leukemia cell HL-60 -RSB- .
19835865	0	stromal-derived_factor-1	12,36	CXCR7	38,43	stromal-derived factor-1	CXCR7	6387	57007	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|nummod|END_ENTITY	The role of stromal-derived_factor-1 -- CXCR7 axis in development and cancer .
26002466	0	stromal-derived_factor-1	92,116	Transforming_growth_factor_b-activated_kinase_1	0,47	stromal-derived factor-1	Transforming growth factor b-activated kinase 1	24772(Tax:10116)	313121(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor_b-activated_kinase_1 negatively regulates interleukin-1a-induced stromal-derived_factor-1 expression in vascular smooth muscle cells .
10382744	0	stromal_cell-derived_factor-1	38,67	CXCR4	14,19	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	progenitors|amod|START_ENTITY receptor|nmod|progenitors Expression|appos|receptor Expression|nmod|END_ENTITY	Expression of CXCR4 , the receptor for stromal_cell-derived_factor-1 on fetal and adult human lympho-hematopoietic progenitors .
10602415	0	stromal_cell-derived_factor-1	138,167	CXCR4	41,46	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	response|nmod|START_ENTITY associated|nmod|response associated|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of the chemokine receptor CXCR4 in B_cell_chronic_lymphocytic_leukemia is associated with increased functional response to stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
10997965	0	stromal_cell-derived_factor-1	43,72	CXCR4	139,144	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	correlates|amod|START_ENTITY blasts|nmod|correlates response|nmod|blasts response|nmod|END_ENTITY	Functional response of leukaemic blasts to stromal_cell-derived_factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic_leukaemia .
11591806	0	stromal_cell-derived_factor-1	60,89	CXCR4	20,25	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	role|amod|START_ENTITY role|nmod|END_ENTITY	A possible role for CXCR4 and its ligand , the CXC chemokine stromal_cell-derived_factor-1 , in the development of bone marrow metastases in neuroblastoma .
14555820	0	stromal_cell-derived_factor-1	14,43	CXCR4	69,74	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	SDF-1|amod|START_ENTITY Production|nmod|SDF-1 Production|nmod|END_ENTITY	Production of stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- and expression of CXCR4 in human bone marrow endothelial cells .
15033938	0	stromal_cell-derived_factor-1	125,154	CXCR4	13,18	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	CXC|amod|START_ENTITY binds|dobj|CXC binds|nsubj|complex complex|compound|END_ENTITY	A syndecan-4 / CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC chemokine stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
16513519	0	stromal_cell-derived_factor-1	82,111	CXCR4	30,35	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	stem|nmod|START_ENTITY stem|nsubj|molecule molecule|amod|mesenchymal mesenchymal|nmod:npmod|stimulates stimulates|nummod|END_ENTITY	The surface adhesion molecule CXCR4 stimulates mesenchymal stem cell migration to stromal_cell-derived_factor-1 in vitro but does not decrease apoptosis under serum deprivation .
17016644	0	stromal_cell-derived_factor-1	49,78	CXCR4	79,84	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Epithelial-mesenchymal transition induced by the stromal_cell-derived_factor-1 / CXCR4 system in oral_squamous_cell_carcinoma cells .
17046575	0	stromal_cell-derived_factor-1	41,70	CXCR4	142,147	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	Cloning|dobj|START_ENTITY Cloning|parataxis|plays plays|nmod|END_ENTITY	Cloning and characterizing mutated human stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- : C-terminal alpha-helix of SDF-1alpha plays a critical role in CXCR4 activation and signaling , but not in CXCR4 binding affinity .
17916907	0	stromal_cell-derived_factor-1	45,74	CXCR4	75,80	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|pathway pathway|nummod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in stromal_cell-derived_factor-1 / CXCR4 pathway of lung_cancer metastasis .
18464929	0	stromal_cell-derived_factor-1	52,81	CXCR4	82,87	stromal cell-derived factor-1	CXCR4	20315(Tax:10090)	12767(Tax:10090)	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	p21Cip1 modulates arterial wound repair through the stromal_cell-derived_factor-1 / CXCR4 axis in mice .
18974109	0	stromal_cell-derived_factor-1	20,49	CXCR4	125,130	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	chemotaxis|amod|START_ENTITY chemotaxis|nmod|receptors receptors|compound|END_ENTITY	Bryostatin-5 blocks stromal_cell-derived_factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors .
19497995	0	stromal_cell-derived_factor-1	48,77	CXCR4	78,83	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	ligand/receptor|amod|START_ENTITY ligand/receptor|compound|END_ENTITY	The influence of tumor-host interactions in the stromal_cell-derived_factor-1 / CXCR4 ligand/receptor axis in determining metastatic risk in breast_cancer .
20484957	0	stromal_cell-derived_factor-1	93,122	CXCR4	123,128	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Pancreatic stellate cells increase the invasion of human pancreatic_cancer cells through the stromal_cell-derived_factor-1 / CXCR4 axis .
20558135	0	stromal_cell-derived_factor-1	75,104	CXCR4	105,110	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Migration of human umbilical cord blood mesenchymal stem cells mediated by stromal_cell-derived_factor-1 / CXCR4 axis via Akt , ERK , and p38 signal transduction pathways .
22664794	0	stromal_cell-derived_factor-1	134,163	CXCR4	164,169	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	axis|amod|START_ENTITY axis|compound|END_ENTITY	Angiotensin_II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal_cell-derived_factor-1 / CXCR4 axis in intrahepatic_cholangiocarcinoma .
23576796	0	stromal_cell-derived_factor-1	101,130	CXCR4	18,23	stromal cell-derived factor-1	CXCR4	24772(Tax:10116)	60628(Tax:10116)	Gene	Gene	gradient|amod|START_ENTITY promotes|nmod|gradient promotes|nsubj|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of CXCR4 in tracheal epithelial cells promotes their proliferation and migration to a stromal_cell-derived_factor-1 gradient .
9886389	0	stromal_cell-derived_factor-1	42,71	CXCR4	116,121	stromal cell-derived factor-1	CXCR4	6387	7852	Gene	Gene	inhibits|advcl|START_ENTITY inhibits|parataxis|evidence evidence|nmod|regulation regulation|nmod|END_ENTITY	TCR activation inhibits chemotaxis toward stromal_cell-derived_factor-1 : evidence for reciprocal regulation between CXCR4 and the TCR .
23098564	0	stromal_cell-derived_factor-1	24,53	CXC_chemokine_ligand_12	0,23	stromal cell-derived factor-1	CXC chemokine ligand 12	6387	6387	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|parataxis|regulates	CXC_chemokine_ligand_12 / stromal_cell-derived_factor-1 regulates cell adhesion in human colon_cancer cells by induction of intercellular_adhesion_molecule-1 .
21041659	0	stromal_cell-derived_factor-1	23,52	SDF-1	54,59	stromal cell-derived factor-1	SDF-1	6387	6387	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Autocrine TGF-beta and stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts .
23599431	0	stromal_cell-derived_factor-1	62,91	SDF-1	93,98	stromal cell-derived factor-1	SDF-1	20315(Tax:10090)	20315(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Induction of C-X-C_chemokine_receptor_type_7 -LRB- CXCR7 -RRB- switches stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- signaling and phagocytic activity in macrophages linked to atherosclerosis .
24929539	0	stromal_cell-derived_factor-1	17,46	Toll-like_receptor_4	66,86	stromal cell-derived factor-1	Toll-like receptor 4	6387	7099	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Resistin-induced stromal_cell-derived_factor-1 expression through Toll-like_receptor_4 and activation of p38 MAPK / NFkB signaling pathway in gastric_cancer cells .
23042611	0	stromal_cell-derived_factor-1	17,46	Visfatin	0,8	stromal cell-derived factor-1	Visfatin	6387	10135	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Visfatin induces stromal_cell-derived_factor-1 expression by b1 integrin signaling in colorectal_cancer cells .
17916907	0	stromal_cell-derived_factor-1	45,74	matrix_metalloproteinase-9	15,41	stromal cell-derived factor-1	matrix metalloproteinase-9	6387	4318	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of matrix_metalloproteinase-9 in stromal_cell-derived_factor-1 / CXCR4 pathway of lung_cancer metastasis .
18709383	0	stromal_cell-derived_factor_1	16,45	SDF-1	47,52	stromal cell-derived factor 1	SDF-1	24772(Tax:10116)	24772(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- expression in microvasculature endothelial cells in retinal_ischemia-reperfusion_injury .
18928845	0	stromal_cell-derived_factor_1	18,47	SDF-1	49,54	stromal cell-derived factor 1	SDF-1	6387	6387	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- in inflamed human dental pulp .
24114538	0	stromal_cell-derived_factor_1	12,41	SDF-1	43,48	stromal cell-derived factor 1	SDF-1	6387	6387	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulated stromal_cell-derived_factor_1 -LRB- SDF-1 -RRB- expression and its interaction with CXCR4 contribute to the pathogenesis of severe pterygia .
7490086	0	stromal_cell-derived_factor_1	52,81	SDF1	83,87	stromal cell-derived factor 1	SDF1	6387	6387	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and chromosomal localization of the human stromal_cell-derived_factor_1 -LRB- SDF1 -RRB- gene .
17284717	0	stromal_cell-derived_factor_1	40,69	fibroblast_growth_factor_2	10,36	stromal cell-derived factor 1	fibroblast growth factor 2	20315(Tax:10090)	14173(Tax:10090)	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Effect of fibroblast_growth_factor_2 on stromal_cell-derived_factor_1 production by bone marrow stromal cells and hematopoiesis .
17553309	0	stromal_cell_derived_factor-1	13,42	CXCR4	43,48	stromal cell derived factor-1	CXCR4	6387	7852	Gene	Gene	role|nmod|START_ENTITY role|dep|axis axis|nummod|END_ENTITY	-LSB- The role of stromal_cell_derived_factor-1 / CXCR4 biological axis in tumor metastasis of non-Hodgkin_lymphoma -RSB- .
23958169	0	stromal_cell_derived_factor_1	47,76	Transforming_growth_factor_b1	1,30	stromal cell derived factor 1	Transforming growth factor b1	6387	7040	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	-LSB- Transforming_growth_factor_b1 cooperates with stromal_cell_derived_factor_1 to affect the proliferation of hepatic oval cells via b-catenin inactivation -RSB- .
23447534	0	stromal_interaction_molecule_1	79,109	Orai1	45,50	stromal interaction molecule 1	Orai1	6786	84876	Gene	Gene	interacting|nmod|START_ENTITY protein|acl|interacting protein|amod|END_ENTITY	Differential roles of the C and N termini of Orai1 protein in interacting with stromal_interaction_molecule_1 -LRB- STIM1 -RRB- for Ca2 + release-activated Ca2 + -LRB- CRAC -RRB- channel activation .
24996186	0	stromal_interaction_molecule_1	52,82	Orai1	100,105	stromal interaction molecule 1	Orai1	6786	84876	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Atomic force microscopy -LRB- AFM -RRB- imaging suggests that stromal_interaction_molecule_1 -LRB- STIM1 -RRB- binds to Orai1 with sixfold symmetry .
17689489	0	stromal_interaction_molecule_1	19,49	STIM1	51,56	stromal interaction molecule 1	STIM1	6786	6786	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Functional role of stromal_interaction_molecule_1 -LRB- STIM1 -RRB- in vascular smooth muscle cells .
24114840	0	stromal_interaction_molecule_1	42,72	STIM1	74,79	stromal interaction molecule 1	STIM1	6786	6786	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	17b-Estradiol inhibits phosphorylation of stromal_interaction_molecule_1 -LRB- STIM1 -RRB- protein : implication for store-operated calcium entry and chronic lung_diseases .
9644265	0	stromal_membrane-associated_protein	15,50	SMAP-1	52,58	stromal membrane-associated protein	SMAP-1	98366(Tax:10090)	98366(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of stromal_membrane-associated_protein -LRB- SMAP-1 -RRB- in erythropoietic microenvironment .
21998657	0	stromelysin-2	7,20	MMP-10	0,6	stromelysin-2	MMP-10	4319	4319	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|appos|promotes	MMP-10 / stromelysin-2 promotes invasion of head_and_neck_cancer .
9662124	0	stromelysin-2	26,39	MMP-10	41,47	stromelysin-2	MMP-10	4319	4319	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Stromelysin-1 _ -LRB- MMP-3 -RRB- and stromelysin-2 -LRB- MMP-10 -RRB- expression in developing human bone : potential roles in skeletal development .
15272933	0	stromelysin-3	23,36	MMP-11	15,21	stromelysin-3	MMP-11	17385(Tax:10090)	17385(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|compound|END_ENTITY	Stimulation of MMP-11 -LRB- stromelysin-3 -RRB- expression in mouse fibroblasts by cytokines , collagen and co-culture with human breast_cancer cell lines .
16165118	0	stromelysin-3	14,27	matrix_metalloproteinase-11	29,56	stromelysin-3	matrix metalloproteinase-11	17385(Tax:10090)	17385(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of stromelysin-3 -LRB- matrix_metalloproteinase-11 -RRB- in macrophages of murine thymus following thymocyte apoptosis .
1639418	0	stromelysin_3	24,37	STMY3	39,44	stromelysin 3	STMY3	4320	4320	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human stromelysin_3 -LRB- STMY3 -RRB- gene to the q11 .2 region of chromosome 22 .
1382977	0	substance_K	136,147	substance_P	124,135	substance K	substance P	6863	6863	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance_P / substance_K receptors .
11597586	0	substance_P	49,60	C-FOS	0,5	substance P	C-FOS	6863	314322(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	C-FOS expression in the rat brain in response to substance_P and neurokinin_B .
19524871	0	substance_P	45,56	CCL2	32,36	substance P	CCL2	6863	6347	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Stimulation of CCL2 -LRB- MCP-1 -RRB- and CCL2 mRNA by substance_P in LAD2 human mast cells .
24577568	0	substance_P	101,112	CD163	84,89	substance P	CD163	6863	9332	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	HIV_infection of macrophages is enhanced in the presence of increased expression of CD163 induced by substance_P .
9852236	0	substance_P	23,34	CD34	38,42	substance P	CD34	6863	947	Gene	Gene	START_ENTITY|nmod|proliferation proliferation|compound|END_ENTITY	Stimulatory effects of substance_P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function .
9700764	0	substance_P	18,29	Cpe	56,59	substance P	Cpe	21333(Tax:10090)	12876(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY levels|dep|END_ENTITY	Reduced levels of substance_P in the brains of Cpe -LRB- fat -RRB- / Cpe -LRB- fat -RRB- mice .
10565569	0	substance_P	29,40	IL-8	122,126	substance P	IL-8	6863	3576	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of the neuropeptides substance_P , calcitonin_gene-related_peptide and alpha-melanocyte-stimulating_hormone on the IL-8 / IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts .
10565569	0	substance_P	29,40	IL-8	127,131	substance P	IL-8	6863	3576	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|system system|compound|END_ENTITY	Effects of the neuropeptides substance_P , calcitonin_gene-related_peptide and alpha-melanocyte-stimulating_hormone on the IL-8 / IL-8 receptor system in a cultured human keratinocyte cell line and dermal fibroblasts .
14743438	0	substance_P	14,25	NF-kappa_B	75,85	substance P	NF-kappa B	6863	4790	Gene	Gene	antagonist|compound|START_ENTITY inhibits|nsubj|antagonist inhibits|dobj|activation activation|amod|END_ENTITY	A non-peptide substance_P antagonist -LRB- CP-96 ,345 -RRB- inhibits morphine-induced NF-kappa_B promoter activation in human NT2-N neurons .
9366421	0	substance_P	17,28	NF-kappa_B	60,70	substance P	NF-kappa B	6863	4790	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	The neuropeptide substance_P activates transcription factor NF-kappa_B and kappa B-dependent gene expression in human astrocytoma cells .
1657150	0	substance_P	6,17	NK-1	28,32	substance P	NK-1	6863	6869	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Human substance_P receptor -LRB- NK-1 -RRB- : organization of the gene , chromosome localization , and functional expression of cDNA clones .
11352645	0	substance_P	23,34	NK-1_receptor	48,61	substance P	NK-1 receptor	6863	6869	Gene	Gene	analogues|compound|START_ENTITY analogues|nmod|END_ENTITY	Internalization of -LSB- 3H -RSB- substance_P analogues in NK-1_receptor transfected CHO cells .
14635685	0	substance_P	65,76	NK-1_receptor	11,24	substance P	NK-1 receptor	21333(Tax:10090)	21336(Tax:10090)	Gene	Gene	significance|nmod|START_ENTITY assess|dobj|significance null|xcomp|assess null|nsubj|use use|nmod|END_ENTITY	The use of NK-1_receptor null mice to assess the significance of substance_P in the carotid body function .
14640725	0	substance_P	43,54	NK-1_receptor	109,122	substance P	NK-1 receptor	6863	6869	Gene	Gene	tags|nmod|START_ENTITY analogues|nsubj|tags analogues|xcomp|identify identify|nmod|END_ENTITY	Isotope and affinity tags in photoreactive substance_P analogues to identify the covalent linkage within the NK-1_receptor by MALDI-TOF analysis .
15911376	0	substance_P	72,83	NK-1_receptor	97,110	substance P	NK-1 receptor	6863	6869	Gene	Gene	tripeptide|nmod|START_ENTITY analysis|nmod|tripeptide bound|nsubj|analysis bound|nmod|END_ENTITY	Conformational analysis of the C-terminal Gly-Leu-Met-NH2 tripeptide of substance_P bound to the NK-1_receptor .
19528498	0	substance_P	15,26	NK-1_receptor	27,40	substance P	NK-1 receptor	6863	6869	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	A role for the substance_P / NK-1_receptor complex in cell proliferation in oral_squamous_cell_carcinoma .
7525569	0	substance_P	69,80	NK-1_receptor	48,61	substance P	NK-1 receptor	6863	6869	Gene	Gene	competition|compound|START_ENTITY affect|dobj|competition affect|nsubj|Mutations Mutations|nmod|II II|nmod|END_ENTITY	Mutations along transmembrane segment II of the NK-1_receptor affect substance_P competition with non-peptide antagonists but not substance_P binding .
7678597	0	substance_P	56,67	NK-1_receptor	94,107	substance P	NK-1 receptor	6863	6869	Gene	Gene	response|nmod|START_ENTITY microglia|nmod|response interleukin-1|nmod|microglia Production|nmod|interleukin-1 Production|dep|role role|nmod|END_ENTITY	Production of interleukin-1 by microglia in response to substance_P : role for a non-classical NK-1_receptor .
8863485	0	substance_P	53,64	NK-1_receptor	109,122	substance P	NK-1 receptor	6863	6869	Gene	Gene	site|compound|START_ENTITY exhibit|dobj|site exhibit|nmod|characteristics characteristics|nmod|END_ENTITY	Human astrocytoma cells -LRB- U-87 MG -RRB- exhibit a specific substance_P binding site with the characteristics of an NK-1_receptor .
9022979	0	substance_P	62,73	NK-1_receptor	11,24	substance P	NK-1 receptor	6863	6869	Gene	Gene	analogues|nmod|START_ENTITY probed|nmod|analogues probed|nsubj|END_ENTITY	Tachykinin NK-1_receptor probed with constrained analogues of substance_P .
9622661	0	substance_P	33,44	NK1	46,49	substance P	NK1	6863	6869	Gene	Gene	localisation|nmod|START_ENTITY localisation|appos|END_ENTITY	Autoradiographic localisation of substance_P -LRB- NK1 -RRB- receptors in human primary visual cortex .
12020057	0	substance_P	42,53	NK1_receptor	55,67	substance P	NK1 receptor	6863	6869	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Elucidating the antidepressant actions of substance_P -LRB- NK1_receptor -RRB- antagonists .
12056558	0	substance_P	48,59	NK1_receptor	61,73	substance P	NK1 receptor	21333(Tax:10090)	21336(Tax:10090)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	New insights into the antidepressant actions of substance_P -LRB- NK1_receptor -RRB- antagonists .
12091546	0	substance_P	25,36	PPT-A	40,45	substance P	PPT-A	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|amod|END_ENTITY	Long-term deprivation of substance_P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network .
7531454	0	substance_P	193,204	Somatostatin	0,12	substance P	Somatostatin	6863	6750	Gene	Gene	morphometry|nmod|START_ENTITY histidine_isoleucine|dep|morphometry histidine_isoleucine|compound|END_ENTITY	Somatostatin , galanin and peptide histidine_isoleucine in the newborn and adult human trigeminal ganglion and spinal nucleus : immunohistochemistry , neuronal morphometry and colocalization with substance_P .
10880748	0	substance_P	76,87	Stem_cell_factor	0,16	substance P	Stem cell factor	21333(Tax:10090)	17311(Tax:10090)	Gene	Gene	responsiveness|nmod|START_ENTITY responsiveness|compound|END_ENTITY	Stem_cell_factor and interleukin-4 increase responsiveness of mast cells to substance_P .
9758897	0	substance_P	43,54	TNF-alpha	30,39	substance P	TNF-alpha	6863	7124	Gene	Gene	produce|nmod|START_ENTITY produce|dobj|END_ENTITY	Human skin mast cells produce TNF-alpha by substance_P .
22878644	0	substance_P	99,110	TRPV1	69,74	substance P	TRPV1	21333(Tax:10090)	193034(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY alters|dobj|expression alters|nsubj|deletion deletion|nmod|receptor receptor|compound|END_ENTITY	Quantitative mass spectrometry analysis reveals that deletion of the TRPV1 receptor in mice alters substance_P and neurokinin_A expression in the central nervous system .
9973426	0	substance_P	111,122	VCAM-1	0,6	substance P	VCAM-1	6863	7412	Gene	Gene	up-regulated|nmod|START_ENTITY up-regulated|nsubj|expression expression|compound|END_ENTITY	VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance_P .
2465985	0	substance_P	207,218	VIP	202,205	substance P	VIP	6863	7432	Gene	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
356933	0	substance_P	19,30	VIP	0,3	substance P	VIP	21333(Tax:10090)	22353(Tax:10090)	Gene	Gene	-|appos|START_ENTITY -|compound|END_ENTITY	VIP - , enkephalin - , substance_P - and somatostatin-like immunoreactivity in neurons intrinsic to the intestine : immunohistochemical evidence from organotypic tissue cultures .
15761654	0	substance_P	64,75	calcitonin_gene-related_peptide	24,55	substance P	calcitonin gene-related peptide	6863	796	Gene	Gene	association|appos|START_ENTITY association|nmod|END_ENTITY	The association between calcitonin_gene-related_peptide -LRB- CGRP -RRB- , substance_P and headache in pituitary_tumours .
2430307	0	substance_P	109,120	dipeptidyl_peptidase_IV	63,86	substance P	dipeptidyl peptidase IV	6863	1803	Gene	Gene	hydrolysis|nmod|START_ENTITY hydrolysis|amod|END_ENTITY	Contamination of highly purified human serum cholinesterase by dipeptidyl_peptidase_IV causing hydrolysis of substance_P .
20074437	0	substance_P	93,104	dopamine_transporter	115,135	substance P	dopamine transporter	6863	6531	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Candidate-gene approach in fibromyalgia syndrome : association analysis of the genes encoding substance_P receptor , dopamine_transporter and alpha1-antitrypsin .
9439602	0	substance_P	89,100	focal_adhesion_kinase	36,57	substance P	focal adhesion kinase	6863	5747	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of phosphorylation of focal_adhesion_kinase and paxillin by combination of substance_P and IGF-1 in SV-40 transformed human corneal_epithelial cells .
11710915	0	substance_P	29,40	nerve_growth_factor	87,106	substance P	nerve growth factor	21333(Tax:10090)	18049(Tax:10090)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|END_ENTITY	The neurosensory tachykinins substance_P and neurokinin_A directly induce keratinocyte nerve_growth_factor .
1379628	0	substance_P	45,56	neurokinin-1	57,69	substance P	neurokinin-1	6863	6863	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Modulatory role of glutathione on mu-opioid , substance_P / neurokinin-1 , and kainic_acid receptor binding sites .
17370082	0	substance_P	9,20	neurokinin-1	38,50	substance P	neurokinin-1	6863	6863	Gene	Gene	Study|nmod|START_ENTITY END_ENTITY|nsubj|Study	Study of substance_P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus .
11588191	0	substance_P	62,73	neurokinin_1	75,87	substance P	neurokinin 1	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	5-hydroxytryptamine -LRB- 5-HT -RRB- 1A autoreceptor adaptive changes in substance_P -LRB- neurokinin_1 -RRB- receptor knock-out mice mimic antidepressant-induced desensitization .
15030389	0	substance_P	12,23	neurokinin_1	25,37	substance P	neurokinin 1	21333(Tax:10090)	21333(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Blockade of substance_P -LRB- neurokinin_1 -RRB- receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor : an in vivo microdialysis study in mice .
2465985	0	substance_P	207,218	pancreatic_polypeptide	220,242	substance P	pancreatic polypeptide	6863	5539	Gene	Gene	neurotensin|dep|START_ENTITY neurotensin|dep|END_ENTITY	Chronic_pancreatitis and diabetes_mellitus : plasma and gastroduodenal_mucosal profiles of regulatory peptides -LRB- gastrin , motilin , secretin , cholecystokinin , gastric inhibitory polypeptide , somatostatin , VIP , substance_P , pancreatic_polypeptide , glucagon , enteroglucagon , neurotensin -RRB- .
6155261	0	substance_P	11,22	somatostatin	60,72	substance P	somatostatin	6863	6750	Gene	Gene	peptides|compound|START_ENTITY Effects|nmod|peptides Effects|nmod|release release|nmod|END_ENTITY	Effects of substance_P and other peptides on the release of somatostatin , insulin , and glucagon in vitro .
1382977	0	substance_P	124,135	substance_K	136,147	substance P	substance K	6863	6863	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance_P / substance_K receptors .
2425412	0	substance_P	20,31	substance_P	75,86	substance P	substance P	6863	6863	Gene	Gene	concentration|compound|START_ENTITY concentration|nmod|END_ENTITY	Flushing and plasma substance_P concentration during infusion of synthetic substance_P in normal man .
2425412	0	substance_P	75,86	substance_P	20,31	substance P	substance P	6863	6863	Gene	Gene	concentration|nmod|START_ENTITY concentration|compound|END_ENTITY	Flushing and plasma substance_P concentration during infusion of synthetic substance_P in normal man .
12906843	0	substance_P_and_vanilloid_receptor	14,48	VR1	50,53	substance P and vanilloid receptor	VR1	21336(Tax:10090)	193034(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of substance_P_and_vanilloid_receptor -LRB- VR1 -RRB- in trigeminal sensory neurons projecting to the mouse nasal mucosa .
7683074	0	substance_P_receptor	20,40	NK-1_receptor	42,55	substance P receptor	NK-1 receptor	24807(Tax:10116)	24807(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of the substance_P_receptor -LRB- NK-1_receptor -RRB- in the central nervous system .
10564361	0	substance_P_receptor	18,38	neurokinin-1	40,52	substance P receptor	neurokinin-1	21336(Tax:10090)	21333(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Disruption of the substance_P_receptor -LRB- neurokinin-1 -RRB- gene does not prevent upregulation of preprotachykinin-A mRNA in the spinal cord of mice following peripheral inflammation .
2384736	0	succinate_dehydrogenase	4,27	SDH	29,32	succinate dehydrogenase	SDH	6390	6390	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Low succinate_dehydrogenase -LRB- SDH -RRB- activity in a patient with a hereditary_myopathy with paroxysmal myoglobinuria .
23612575	0	succinate_dehydrogenase	57,80	SDHD	44,48	succinate dehydrogenase	SDHD	6390	6392	Gene	Gene	complex|amod|START_ENTITY END_ENTITY|nmod|complex	Analysis of all subunits , SDHA , SDHB , SDHC , SDHD , of the succinate_dehydrogenase complex in KIT/PDGFRA wild-type GIST .
23747254	0	succinate_dehydrogenase	75,98	TRAP1	28,33	succinate dehydrogenase	TRAP1	6390	10131	Gene	Gene	inhibiting|dobj|START_ENTITY promotes|advcl|inhibiting promotes|nsubj|END_ENTITY	The mitochondrial chaperone TRAP1 promotes neoplastic_growth by inhibiting succinate_dehydrogenase .
22804613	0	succinate_dehydrogenase_subunit_B	8,41	SDHB	43,47	succinate dehydrogenase subunit B	SDHB	6390	6390	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of succinate_dehydrogenase_subunit_B -LRB- SDHB -RRB- expression is limited to a distinctive subset of gastric wild-type gastrointestinal_stromal_tumours : a comprehensive genotype-phenotype correlation study .
21792967	0	succinate_dehydrogenase_subunit_D	30,63	SDHD	65,69	succinate dehydrogenase subunit D	SDHD	6392	6392	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Is the c. 3G > C mutation in the succinate_dehydrogenase_subunit_D -LRB- SDHD -RRB- gene due to a founder effect in Chinese head_and_neck_paraganglioma patients ?
14635103	0	succinate_semialdehyde_dehydrogenase	27,63	ALDH5A1	65,72	succinate semialdehyde dehydrogenase	ALDH5A1	7915	7915	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutational spectrum of the succinate_semialdehyde_dehydrogenase -LRB- ALDH5A1 -RRB- gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH_deficiency .
19040727	0	succinate_semialdehyde_dehydrogenase	42,78	SSADH	80,85	succinate semialdehyde dehydrogenase	SSADH	214579(Tax:10090)	214579(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Neurotransmitter alterations in embryonic succinate_semialdehyde_dehydrogenase -LRB- SSADH -RRB- deficiency suggest a heightened excitatory state during development .
4465902	0	succinic_dehydrogenase	26,48	SDH	50,53	succinic dehydrogenase	SDH	6390	6390	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	The effect of malonate on succinic_dehydrogenase -LRB- SDH -RRB- activity during the multiplication of influenza and herpes viruses in the embryonate hen egg .
6425114	1	succinic_dehydrogenase	120,142	SDH	144,147	succinic dehydrogenase	SDH	6390	6390	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	I. Effect of T4 and thiourea on succinic_dehydrogenase -LRB- SDH -RRB- activity and protein content .
12534938	0	succinyl_CoA_transferase	27,51	SCOT	53,57	succinyl CoA transferase	SCOT	64059(Tax:10090)	64059(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Differential expression of succinyl_CoA_transferase -LRB- SCOT -RRB- genes in somatic and germline cells of the mouse testis .
26972481	0	sulfakinin	47,57	Insulin_receptor	0,16	sulfakinin	Insulin receptor	103313277	661524(Tax:7070)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Insulin_receptor regulates food intake through sulfakinin signaling in the red_flour_beetle , Tribolium_castaneum .
19373441	0	sulfatase_1	39,50	SULF1	52,57	sulfatase 1	SULF1	23213	23213	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	The tumor suppressor function of human sulfatase_1 -LRB- SULF1 -RRB- in carcinogenesis .
7702875	0	sulfated_glycoprotein-1	8,31	SGP-1	33,38	sulfated glycoprotein-1	SGP-1	25524(Tax:10116)	25524(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of sulfated_glycoprotein-1 -LRB- SGP-1 -RRB- in the disposal of residual bodies by Sertoli cells of the rat .
8573994	0	sulfated_glycoprotein-1	18,41	prosaposin	49,59	sulfated glycoprotein-1	prosaposin	25524(Tax:10116)	5660	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Molecular role of sulfated_glycoprotein-1 -LRB- SGP-1 / prosaposin -RRB- in Sertoli cells .
17558187	0	sulfated_glycoprotein-2	22,45	SGP-2	47,52	sulfated glycoprotein-2	SGP-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression pattern of sulfated_glycoprotein-2 -LRB- SGP-2 -RRB- mRNA in rat testes exposed to endocrine disruptors .
9037392	0	sulfated_glycoprotein-2	58,81	clusterin	83,92	sulfated glycoprotein-2	clusterin	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The effect of estradiol-induced hypothalamic pathology on sulfated_glycoprotein-2 -LRB- clusterin -RRB- expression in the hypothalamus .
9713325	0	sulfated_glycoprotein-2	35,58	clusterin	24,33	sulfated glycoprotein-2	clusterin	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Transient expression of clusterin -LRB- sulfated_glycoprotein-2 -RRB- during development of rat pancreas .
15262279	0	sulfonylurea_receptor	20,41	SUR	43,46	sulfonylurea receptor	SUR	34350(Tax:7227)	34350(Tax:7227)	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	Significance of the sulfonylurea_receptor -LRB- SUR -RRB- as the target of diflubenzuron in chitin synthesis inhibition in Drosophila_melanogaster and Blattella_germanica .
8635661	0	sulfonylurea_receptor	25,46	SUR	48,51	sulfonylurea receptor	SUR	6833	6833	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sequence variants in the sulfonylurea_receptor -LRB- SUR -RRB- gene are associated with NIDDM in Caucasians .
9851882	0	sulfonylurea_receptor	129,150	SUR	152,155	sulfonylurea receptor	SUR	6833	6833	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A human succinate-ubiquinone oxidoreductase CII-3 subunit gene ending in a polymorphic dinucleotide repeat is located within the sulfonylurea_receptor -LRB- SUR -RRB- gene .
9769320	0	sulfonylurea_receptor	25,46	SUR1	48,52	sulfonylurea receptor	SUR1	6833	6833	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Paternal mutation of the sulfonylurea_receptor -LRB- SUR1 -RRB- gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous_hyperplasia .
11030411	0	sulfonylurea_receptor_1	43,66	SUR1	68,72	sulfonylurea receptor 1	SUR1	6833	6833	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of a variant in exon 31 of the sulfonylurea_receptor_1 -LRB- SUR1 -RRB- gene with type_2_diabetes_mellitus in French Caucasians .
12149601	0	sulfonylurea_receptor_1	36,59	SUR1	61,65	sulfonylurea receptor 1	SUR1	6833	6833	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic variation in exon 18 of the sulfonylurea_receptor_1 -LRB- SUR1 -RRB- gene , insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects .
17496234	0	sulfonylurea_receptor_1	129,152	syntaxin-1A	107,118	sulfonylurea receptor 1	syntaxin-1A	25559(Tax:10116)	116470(Tax:10116)	Gene	Gene	acting|nmod|START_ENTITY acting|amod|END_ENTITY	The actions of a novel potent islet beta-cell specific ATP-sensitive K + channel opener can be modulated by syntaxin-1A acting on sulfonylurea_receptor_1 .
8459652	0	sulfotransferase	52,68	ST1A1	70,75	sulfotransferase	ST1A1	83783(Tax:10116)	83783(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Expression and functional characterization of a rat sulfotransferase -LRB- ST1A1 -RRB- cDNA for sulfations of phenolic substrates in COS-1 cells .
15878968	0	sulfotransferase	53,69	SULT2A1	71,78	sulfotransferase	SULT2A1	6822	6822	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- by estrogen-related_receptor_alpha .
23436881	0	sulfotransferase	42,58	SULT2A1	59,66	sulfotransferase	SULT2A1	6822	6822	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Relationship between polymorphisms in the sulfotransferase SULT2A1 gene and dehydroepiandrosterone_sulfate concentration in children .
15878968	0	sulfotransferase	53,69	estrogen-related_receptor_alpha	83,114	sulfotransferase	estrogen-related receptor alpha	6822	2101	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of dehydroepiandrosterone sulfotransferase -LRB- SULT2A1 -RRB- by estrogen-related_receptor_alpha .
17963788	0	sulfotransferase_1A3	19,39	SULT1A3	41,48	sulfotransferase 1A3	SULT1A3	6818	6818	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of human sulfotransferase_1A3 -LRB- SULT1A3 -RRB- by glucocorticoids .
19420132	0	sulfotransferase_2A1	18,38	SULT2A1	40,47	sulfotransferase 2A1	SULT2A1	6822	6822	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Selective role of sulfotransferase_2A1 -LRB- SULT2A1 -RRB- in the N-sulfoconjugation of quinolone drugs in humans .
19439498	0	sulfotransferase_4A1	15,35	Pin1	91,95	sulfotransferase 4A1	Pin1	25830	5300	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	Cytosolic Aryl sulfotransferase_4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1 .
18407553	0	sulphamidase	32,44	SGSH	51,55	sulphamidase	SGSH	6448	6448	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The mutation p.Ser298Pro in the sulphamidase gene -LRB- SGSH -RRB- is associated with a slowly progressive clinical phenotype in mucopolysaccharidosis_type_IIIA -LRB- Sanfilippo_A_syndrome -RRB- .
11959419	0	super_cervical_ganglion-10	14,40	SCG-10	42,48	super cervical ganglion-10	SCG-10	11075	11075	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of super_cervical_ganglion-10 -LRB- SCG-10 -RRB- mRNA in the monkey cerebral cortex during postnatal development .
22490392	0	superficial_zone_protein	13,37	SZP	39,42	superficial zone protein	SZP	10216	10216	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of superficial_zone_protein -LRB- SZP -RRB- / lubricin/PRG _ 4 in muscle-derived mesenchymal stem/progenitor cells by transforming_growth_factor-b1 and bone_morphogenetic_protein-7 .
23848497	0	superficial_zone_protein	46,70	TGF-b1	97,103	superficial zone protein	TGF-b1	10216	7040	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|explants explants|nmod|END_ENTITY	Induction of chondrogenesis and expression of superficial_zone_protein in synovial explants with TGF-b1 and BMP-7 .
19702511	0	superficial_zone_protein	152,176	lubricin	177,185	superficial zone protein	lubricin	10216	10216	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Mesenchymal progenitor cells derived from synovium and infrapatellar fat pad as a source for superficial zone cartilage tissue engineering : analysis of superficial_zone_protein / lubricin expression .
10601249	0	superoxide_dismutase	10,30	SOD	32,35	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	A gain of superoxide_dismutase -LRB- SOD -RRB- activity obtained with CCS , the copper_metallochaperone for SOD1 .
12624786	0	superoxide_dismutase	121,141	SOD	143,146	superoxide dismutase	SOD	6647	6647	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Immunohistochemical expression of inducible nitric_oxide synthase -LRB- iNOS -RRB- in human brain_tumors : relationships of iNOS to superoxide_dismutase -LRB- SOD -RRB- proteins -LRB- SOD1 and SOD2 -RRB- , Ki-67 antigen -LRB- MIB-1 -RRB- and p53 protein .
17395009	0	superoxide_dismutase	36,56	SOD	58,61	superoxide dismutase	SOD	6647	6647	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|appos|END_ENTITY	Inactivation and nitration of human superoxide_dismutase -LRB- SOD -RRB- by fluxes of nitric_oxide and superoxide .
19049830	0	superoxide_dismutase	19,39	SOD	41,44	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Increased level of superoxide_dismutase -LRB- SOD -RRB- activity in larvae of Chironomus ramosus -LRB- Diptera : Chironomidae -RRB- subjected to ionizing radiation .
2130521	0	superoxide_dismutase	68,88	SOD	90,93	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	In vivo effect of free radical scavenger hepatoprotective agents on superoxide_dismutase -LRB- SOD -RRB- activity in patients .
21565362	0	superoxide_dismutase	14,34	SOD	36,39	superoxide dismutase	SOD	6647	6647	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Expression of superoxide_dismutase -LRB- SOD -RRB- genes from the copper-exposed polychaete , Neanthes succinea .
2625108	0	superoxide_dismutase	18,38	SOD	40,43	superoxide dismutase	SOD	6647	6647	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of superoxide_dismutase -LRB- SOD -RRB- in serum of cancer patients by microchemical luminescence -RSB- .
2733245	0	superoxide_dismutase	13,33	SOD	35,38	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Human plasma superoxide_dismutase -LRB- SOD -RRB- activity on reperfusion_injury with successful thrombolysis in acute myocardial_infarction .
3495372	0	superoxide_dismutase	41,61	SOD	63,66	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Relationship between melanin content and superoxide_dismutase -LRB- SOD -RRB- activity in the liver of various species of animals .
7921164	0	superoxide_dismutase	7,27	SOD	29,32	superoxide dismutase	SOD	6647	6647	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Normal superoxide_dismutase -LRB- SOD -RRB- gene in pregnancy-induced hypertension : is the decreased SOD activity a secondary phenomenon ?
8033747	0	superoxide_dismutase	51,71	SOD	73,76	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	-LSB- Study on correlation and clinical significance of superoxide_dismutase -LRB- SOD -RRB- activity and content in 102 patients with leukemia -RSB- .
8292974	0	superoxide_dismutase	60,80	SOD	82,85	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effect of the natural bioflavonoid antioxidant silymarin on superoxide_dismutase -LRB- SOD -RRB- activity and expression in vitro .
8372889	0	superoxide_dismutase	14,34	SOD	36,39	superoxide dismutase	SOD	6647	6647	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of superoxide_dismutase -LRB- SOD -RRB- in adenomyosis .
8920222	0	superoxide_dismutase	54,74	SOD	76,79	superoxide dismutase	SOD	6647	6647	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	An improved technique for the assay of red blood cell superoxide_dismutase -LRB- SOD -RRB- activity .
6883177	0	superoxide_dismutase	14,34	SOD-1	36,41	superoxide dismutase	SOD-1	397036(Tax:9823)	397036(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of superoxide_dismutase -LRB- SOD-1 -RRB- gene to chromosome No. 9 of domestic_pig .
16564582	0	superoxide_dismutase	44,64	SOD1	66,70	superoxide dismutase	SOD1	106057618	106057618	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Biomphalaria_glabrata cytosolic copper/zinc _ superoxide_dismutase -LRB- SOD1 -RRB- gene : association of SOD1 alleles with resistance/susceptibility to Schistosoma_mansoni .
22542607	0	superoxide_dismutase	67,87	SOD1	91,95	superoxide dismutase	SOD1	6647	403559(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Degenerative_myelopathy associated with a missense mutation in the superoxide_dismutase 1 -LRB- SOD1 -RRB- gene progresses to peripheral_neuropathy in Pembroke Welsh corgis and boxers .
23264618	0	superoxide_dismutase	57,77	SOD1	79,83	superoxide dismutase	SOD1	6647	6647	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Disulfide scrambling describes the oligomer formation of superoxide_dismutase -LRB- SOD1 -RRB- proteins in the familial form of amyotrophic_lateral_sclerosis .
23394364	0	superoxide_dismutase	30,50	SOD1	54,58	superoxide dismutase	SOD1	397036(Tax:9823)	397036(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Potential role of the porcine superoxide_dismutase 1 -LRB- SOD1 -RRB- gene in pig reproduction .
3707996	0	superoxide_dismutase	82,102	Sod	104,107	superoxide dismutase	Sod	100274012(Tax:4577)	100274012(Tax:4577)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Effect of the free radical-generating herbicide paraquat on the expression of the superoxide_dismutase -LRB- Sod -RRB- genes in maize .
7989831	0	superoxide_dismutase	36,56	adenosine_deaminase	6,25	superoxide dismutase	adenosine deaminase	6647	100	Gene	Gene	activities|compound|START_ENTITY activities|compound|END_ENTITY	Serum adenosine_deaminase and total superoxide_dismutase activities before and after surgical removal of cancerous laryngeal tissue .
14684739	0	superoxide_dismutase-1	85,107	NEDL1	0,5	superoxide dismutase-1	NEDL1	6647	23072	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	NEDL1 , a novel ubiquitin-protein isopeptide ligase for dishevelled-1 , targets mutant superoxide_dismutase-1 .
11771762	0	superoxide_dismutase-1	37,59	SOD-1	61,66	superoxide dismutase-1	SOD-1	6647	6647	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Antioxidant proteins in fetal brain : superoxide_dismutase-1 -LRB- SOD-1 -RRB- protein is not overexpressed in fetal Down syndrome .
22608880	0	superoxide_dismutase-1	22,44	SOD1	46,50	superoxide dismutase-1	SOD1	6647	6647	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic variations in superoxide_dismutase-1 -LRB- SOD1 -RRB- gene and renal and cardiovascular_morbidity and mortality in type 2 diabetic subjects .
25908445	0	superoxide_dismutase_1	4,26	AUF-1	136,141	superoxide dismutase 1	AUF-1	6647	3184	Gene	Gene	expression|amod|START_ENTITY expression|dep|involvement involvement|nmod|END_ENTITY	The superoxide_dismutase_1 3 ` UTR maintains high expression of the SOD1 gene in cancer cells : The involvement of the RNA-binding_protein AUF-1 .
10944535	0	superoxide_dismutase_1	21,43	SOD1	45,49	superoxide dismutase 1	SOD1	853568(Tax:4932)	853568(Tax:4932)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Copper activation of superoxide_dismutase_1 -LRB- SOD1 -RRB- in vivo .
25908445	0	superoxide_dismutase_1	4,26	SOD1	66,70	superoxide dismutase 1	SOD1	6647	6647	Gene	Gene	expression|amod|START_ENTITY expression|nmod|gene gene|compound|END_ENTITY	The superoxide_dismutase_1 3 ` UTR maintains high expression of the SOD1 gene in cancer cells : The involvement of the RNA-binding_protein AUF-1 .
7608718	0	superoxide_dismutase_1	16,38	SOD_1	40,45	superoxide dismutase 1	SOD 1	6647	6647	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence of the superoxide_dismutase_1 -LRB- SOD_1 -RRB- gene in familial Parkinson 's _ disease .
24339725	0	superoxide_dismutase_1	12,34	dual-specificity_phosphatase_1	36,66	superoxide dismutase 1	dual-specificity phosphatase 1	6647	1843	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|amod|END_ENTITY	Analysis of superoxide_dismutase_1 , dual-specificity_phosphatase_1 , and transforming_growth_factor , _ beta_1 genes expression in keratoconic and non-keratoconic corneas .
19546220	0	suppression_of_tumorigenicity_14	6,38	ST14	0,4	suppression of tumorigenicity 14	ST14	6768	6768	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	ST14 -LRB- suppression_of_tumorigenicity_14 -RRB- gene is a target for miR-27b , and the inhibitory effect of ST14 on cell growth is independent of miR-27b regulation .
20959556	0	suppression_of_tumorigenicity_2	8,39	ST2	41,44	suppression of tumorigenicity 2	ST2	17082(Tax:10090)	17082(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Loss of suppression_of_tumorigenicity_2 -LRB- ST2 -RRB- gene reverses sepsis-induced inhibition of lung host defense in mice .
26085211	0	suppressor_of_cytokine_signaling	108,140	SOCS	142,146	suppressor of cytokine signaling	SOCS	12700(Tax:10090)	12700(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Kinase inhibition , competitive binding and proteasomal degradation : resolving the molecular function of the suppressor_of_cytokine_signaling -LRB- SOCS -RRB- proteins .
23134344	0	suppressor_of_cytokine_signaling	127,159	SOCS-1	161,167	suppressor of cytokine signaling	SOCS-1	1154	8651	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Overexpression of signal transducer and activator of transcription -LRB- STAT-3 and STAT-5 -RRB- transcription factors and alteration of suppressor_of_cytokine_signaling -LRB- SOCS-1 -RRB- protein in prostate_cancer .
10403376	0	suppressor_of_cytokine_signaling	16,48	SOCS-2	50,56	suppressor of cytokine signaling	SOCS-2	8835	8835	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Dual effects of suppressor_of_cytokine_signaling -LRB- SOCS-2 -RRB- on growth_hormone signal transduction .
17126530	0	suppressor_of_cytokine_signaling-1	33,67	IL-21	14,19	suppressor of cytokine signaling-1	IL-21	12703(Tax:10090)	60505(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Regulation of IL-21 signaling by suppressor_of_cytokine_signaling-1 -LRB- SOCS1 -RRB- in CD8 -LRB- + -RRB- T lymphocytes .
21385099	0	suppressor_of_cytokine_signaling-1	39,73	SOCS-1	75,81	suppressor of cytokine signaling-1	SOCS-1	8651	8651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Methylation-mediated gene silencing of suppressor_of_cytokine_signaling-1 -LRB- SOCS-1 -RRB- gene in esophageal_squamous_cell_carcinoma patients of Kashmir valley .
17469064	0	suppressor_of_cytokine_signaling-2	44,78	SOCS2	80,85	suppressor of cytokine signaling-2	SOCS2	100855737	100855737	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of variation in the canine suppressor_of_cytokine_signaling-2 -LRB- SOCS2 -RRB- gene .
24484474	0	suppressor_of_cytokine_signaling-2	16,50	TrkA	72,76	suppressor of cytokine signaling-2	TrkA	84607(Tax:10116)	59109(Tax:10116)	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	A novel role of suppressor_of_cytokine_signaling-2 in the regulation of TrkA neurotrophin receptor biology .
17114447	0	suppressor_of_cytokine_signaling-3	84,118	IL-10	0,5	suppressor of cytokine signaling-3	IL-10	9021	3586	Gene	Gene	induction|nmod|START_ENTITY inhibits|nmod|induction inhibits|nsubj|END_ENTITY	IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor_of_cytokine_signaling-3 .
18237746	0	suppressor_of_cytokine_signaling-3	34,68	SOCS-3	70,76	suppressor of cytokine signaling-3	SOCS-3	9021	9021	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the suppressor_of_cytokine_signaling-3 -LRB- SOCS-3 -RRB- gene via STAT3 is increased in F9 REX1 -LRB- ZFP-42 -RRB- knockout teratocarcinoma stem cells relative to wild-type cells .
15535835	0	suppressor_of_cytokine_signaling_1	80,114	CD4	118,121	suppressor of cytokine signaling 1	CD4	8651	920	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor_of_cytokine_signaling_1 in CD4 + T cells from patients with rheumatoid_arthritis .
24997329	0	suppressor_of_cytokine_signaling_1	19,53	SOCS1	55,60	suppressor of cytokine signaling 1	SOCS1	8651	8651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- gene polymorphisms with acute_coronary_syndrome in Mexican patients .
25701091	0	suppressor_of_cytokine_signaling_1	14,48	SOCS1	50,55	suppressor of cytokine signaling 1	SOCS1	8651	8651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of suppressor_of_cytokine_signaling_1 -LRB- SOCS1 -RRB- gene dramatically increases in relapsing-remitting multiple_sclerosis .
18843197	0	suppressor_of_cytokine_signaling_1	33,67	Socs1	69,74	suppressor of cytokine signaling 1	Socs1	252971(Tax:10116)	252971(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic downregulation of the suppressor_of_cytokine_signaling_1 -LRB- Socs1 -RRB- gene is associated with the STAT3 activation and development of hepatocellular_carcinoma induced by methyl-deficiency in rats .
16406727	0	suppressor_of_cytokine_signaling_2	54,88	SOCS2	90,95	suppressor of cytokine signaling 2	SOCS2	8835	8835	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of single-nucleotide polymorphisms in the suppressor_of_cytokine_signaling_2 -LRB- SOCS2 -RRB- gene with type_2_diabetes in the Japanese .
15972659	0	suppressor_of_cytokine_signaling_3	71,105	Heat_shock_protein_60	0,21	suppressor of cytokine signaling 3	Heat shock protein 60	12702(Tax:10090)	15510(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Heat_shock_protein_60 activates cytokine-associated negative regulator suppressor_of_cytokine_signaling_3 in T cells : effects on signaling , chemotaxis , and inflammation .
16493033	0	suppressor_of_cytokine_signaling_3	81,115	IL-27	0,5	suppressor of cytokine signaling 3	IL-27	12702(Tax:10090)	246779(Tax:10090)	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	IL-27 suppresses CD28-mediated -LSB- correction of medicated -RSB- IL-2 production through suppressor_of_cytokine_signaling_3 .
12626585	0	suppressor_of_cytokine_signaling_3	98,132	IL-6	23,27	suppressor of cytokine signaling 3	IL-6	9021	3569	Gene	Gene	modulated|nmod|START_ENTITY modulated|nsubjpass|Activation Activation|nmod|STAT3 STAT3|nmod|END_ENTITY	Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor_of_cytokine_signaling_3 .
26774658	0	suppressor_of_cytokine_signaling_3	91,125	IL-6	0,4	suppressor of cytokine signaling 3	IL-6	9021	3569	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor_of_cytokine_signaling_3 .
17609438	0	suppressor_of_cytokine_signaling_3	14,48	SOC3	50,54	suppressor of cytokine signaling 3	SOC3	9021	9021	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOC3 -RRB- by growth_hormone in pro-B cells .
26797799	0	suppressor_of_cytokine_signaling_3	36,70	SOCS3	72,77	suppressor of cytokine signaling 3	SOCS3	9021	9021	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the anti-inflammatory suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- in human clear_cell_renal_cell_carcinoma .
17312125	0	suppressor_of_cytokine_signaling_3	14,48	TNF-alpha	75,84	suppressor of cytokine signaling 3	TNF-alpha	9021	7124	Gene	Gene	stability|amod|START_ENTITY stability|nmod|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOCS3 -RRB- mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade .
24839265	0	suppressor_of_cytokine_signaling_3	12,46	gp130	61,66	suppressor of cytokine signaling 3	gp130	12702(Tax:10090)	16195(Tax:10090)	Gene	Gene	START_ENTITY|acl|regulating regulating|dobj|END_ENTITY	Key role of suppressor_of_cytokine_signaling_3 in regulating gp130 cytokine-induced signaling and limiting chondrocyte responses during murine inflammatory_arthritis .
17609438	0	suppressor_of_cytokine_signaling_3	14,48	growth_hormone	59,73	suppressor of cytokine signaling 3	growth hormone	9021	2688	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of suppressor_of_cytokine_signaling_3 -LRB- SOC3 -RRB- by growth_hormone in pro-B cells .
12591901	0	suppressor_of_cytokine_signaling_3	10,44	interleukin_2	80,93	suppressor of cytokine signaling 3	interleukin 2	12702(Tax:10090)	16183(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|production production|amod|END_ENTITY	A role of suppressor_of_cytokine_signaling_3 -LRB- SOCS3/CIS3/SSI3 -RRB- in CD28-mediated interleukin_2 production .
25377316	0	suppressor_of_cytokine_signaling_3	22,56	tumor_necrosis_factor-a	97,120	suppressor of cytokine signaling 3	tumor necrosis factor-a	9021	7124	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Intestinal epithelial suppressor_of_cytokine_signaling_3 enhances microbial-induced inflammatory tumor_necrosis_factor-a , contributing to epithelial barrier dysfunction .
12865927	0	suppressor_of_cytokine_signalling-1	24,59	SOCS-1	61,67	suppressor of cytokine signalling-1	SOCS-1	8651	8651	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aberrant methylation of suppressor_of_cytokine_signalling-1 -LRB- SOCS-1 -RRB- gene in pancreatic_ductal_neoplasms .
17030374	0	suppressor_of_cytokine_signalling-1	4,39	SOCS-1	41,47	suppressor of cytokine signalling-1	SOCS-1	8651	8651	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The suppressor_of_cytokine_signalling-1 -LRB- SOCS-1 -RRB- gene is overexpressed in Philadelphia chromosome negative chronic_myeloproliferative_disorders .
19470084	0	suppressor_of_cytokine_signalling_2	28,63	SOCS-2	65,71	suppressor of cytokine signalling 2	SOCS-2	216233(Tax:10090)	216233(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Heterogeneous expression of suppressor_of_cytokine_signalling_2 -LRB- SOCS-2 -RRB- in liver tissue .
16309496	0	suppressor_of_cytokine_signalling_3	22,57	SOCS3	59,64	suppressor of cytokine signalling 3	SOCS3	9021	9021	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- in severe atopic_dermatitis .
23782265	0	suppressor_of_cytokine_signalling_3	36,71	SOCS3	73,78	suppressor of cytokine signalling 3	SOCS3	9021	9021	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Flavanoids induce expression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- gene and suppress IL-6-activated signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in vascular endothelial cells .
23782265	0	suppressor_of_cytokine_signalling_3	36,71	STAT3	165,170	suppressor of cytokine signalling 3	STAT3	9021	6774	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Flavanoids induce expression of the suppressor_of_cytokine_signalling_3 -LRB- SOCS3 -RRB- gene and suppress IL-6-activated signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- activation in vascular endothelial cells .
9806929	0	sur-2	86,91	lin-25	23,29	sur-2	lin-25	173345(Tax:6239)	179732(Tax:6239)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Caenorhabditis_elegans lin-25 : cellular focus , protein expression and requirement for sur-2 during induction of vulval fates .
1289235	0	surfactant-associated_protein	25,54	SP-A	56,60	surfactant-associated protein	SP-A	729238	729238	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of pulmonary surfactant-associated_protein -LRB- SP-A -RRB- with surfactant lipids .
2188684	0	surfactant-associated_protein_B	31,62	SP-B	64,68	surfactant-associated protein B	SP-B	6439	507398(Tax:9913)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of mature pulmonary surfactant-associated_protein_B -LRB- SP-B -RRB- in Escherichia_coli using truncated human SP-B cDNAs .
8216208	0	surfactant-associated_protein_B	15,46	SP-B	48,52	surfactant-associated protein B	SP-B	6439	6439	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|appos|END_ENTITY	Degradation of surfactant-associated_protein_B -LRB- SP-B -RRB- during in vitro conversion of large to small surfactant aggregates .
1540386	0	surfactant-associated_protein_C	16,47	SP-C	49,53	surfactant-associated protein C	SP-C	100009162(Tax:9986)	100009162(Tax:9986)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of surfactant-associated_protein_C -LRB- SP-C -RRB- mRNA in fetal rabbit lung tissue by in situ hybridization .
2167698	0	surfactant_protein	13,31	SP-A	33,37	surfactant protein	SP-A	24773(Tax:10116)	24773(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of surfactant_protein -LRB- SP-A -RRB- biosynthesis and SP-A mRNA in activated type II cells during acute silicosis in rats .
16916954	0	surfactant_protein-A	41,61	Estrogen_related_receptor-alpha	0,31	surfactant protein-A	Estrogen related receptor-alpha	653509	2101	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Estrogen_related_receptor-alpha enhances surfactant_protein-A gene expression in fetal lung type II cells .
10101009	0	surfactant_protein-A	23,43	Glycoprotein-340	0,16	surfactant protein-A	Glycoprotein-340	653509	1755	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Glycoprotein-340 binds surfactant_protein-A -LRB- SP-A -RRB- and stimulates alveolar macrophage migration in an SP-A-independent manner .
8996657	0	surfactant_protein-A	50,70	Interleukin-1_alpha	0,19	surfactant protein-A	Interleukin-1 alpha	100009044(Tax:9986)	100009250(Tax:9986)	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-1_alpha upregulates the expression of surfactant_protein-A in rabbit lung explants .
15047952	0	surfactant_protein-A	53,73	SP-A	75,79	surfactant protein-A	SP-A	653509	653509	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Linkage of neutrophil serine proteases and decreased surfactant_protein-A -LRB- SP-A -RRB- levels in inflammatory_lung_disease .
16621351	4	surfactant_protein-A	394,414	SP-A	416,420	surfactant protein-C	SP-C	6440	6440	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	There are four non-serum proteins surfactant_protein-A -LRB- SP-A -RRB- , surfactant_protein-B -LRB- SP-B -RRB- , surfactant_protein-C -LRB- SP-C -RRB- and surfactant_protein-D -LRB- SP-D -RRB- named in chronologic order of discovery .
17307210	0	surfactant_protein-A	8,28	SP-A	30,34	surfactant protein-A	SP-A	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of surfactant_protein-A -LRB- SP-A -RRB- in lung_injury in response to acute ozone exposure of SP-A deficient mice .
18079322	0	surfactant_protein-A	53,73	SP-A	75,79	surfactant protein-A	SP-A	653509	653509	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Glucocorticoid/glucocorticoid _ receptor inhibition of surfactant_protein-A -LRB- SP-A -RRB- gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter .
15700120	0	surfactant_protein-D	27,47	SFTPD	49,54	surfactant protein-D	SFTPD	6441	6441	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the human surfactant_protein-D -LRB- SFTPD -RRB- gene : strong evidence that serum levels of surfactant_protein-D -LRB- SP-D -RRB- are genetically influenced .
18785967	0	surfactant_protein-D	42,62	SFTPD	64,69	surfactant protein-D	SFTPD	6441	6441	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of polymorphisms in the human surfactant_protein-D -LRB- SFTPD -RRB- gene and postnatal pulmonary adaptation in the preterm infant .
11967276	0	surfactant_protein-D	22,42	SP-D	44,48	surfactant protein-D	SP-D	6441	6441	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of surfactant_protein-D -LRB- SP-D -RRB- in human fetal , newborn , and adult tissues .
9844346	0	surfactant_protein-D	23,43	SP-D	45,49	surfactant protein-D	SP-D	6441	6441	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	-LSB- Significance of serum surfactant_protein-D -LRB- SP-D -RRB- level in patients with pulmonary_tuberculosis -RSB- .
16263772	0	surfactant_protein_A	65,85	11Beta-hydroxysteroid_dehydrogenase_type_2	0,42	surfactant protein A	11Beta-hydroxysteroid dehydrogenase type 2	653509	3291	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	11Beta-hydroxysteroid_dehydrogenase_type_2 and the regulation of surfactant_protein_A by dexamethasone metabolites .
10625644	0	surfactant_protein_A	34,54	GATA-6	0,6	surfactant protein A	GATA-6	20387(Tax:10090)	14465(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	GATA-6 activates transcription of surfactant_protein_A .
10762543	0	surfactant_protein_A	24,44	SP-A	46,50	surfactant protein A	SP-A	653509	653509	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the surfactant_protein_A -LRB- SP-A -RRB- gene locus and respiratory-distress_syndrome in the Finnish population .
11028547	0	surfactant_protein_A	10,30	SP-A	32,36	surfactant protein A	SP-A	653509	653509	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of surfactant_protein_A -LRB- SP-A -RRB- on the production of cytokines by human pulmonary macrophages .
11751208	0	surfactant_protein_A	48,68	SP-A	70,74	surfactant protein A	SP-A	653509	653509	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Intracellular and intraalveolar localization of surfactant_protein_A -LRB- SP-A -RRB- in the parenchymal region of the human lung .
12020822	0	surfactant_protein_A	91,111	SP-A	113,117	surfactant protein A	SP-A	24773(Tax:10116)	24773(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant_protein_A -LRB- SP-A -RRB- genes .
15932345	0	surfactant_protein_A	21,41	SP-A	15,19	surfactant protein A	SP-A	653509	653509	Gene	Gene	Interaction|appos|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of SP-A -LRB- surfactant_protein_A -RRB- with bacterial rough lipopolysaccharide -LRB- Re-LPS -RRB- , and effects of SP-A on the binding of Re-LPS to CD14 and LPS-binding_protein .
1846339	0	surfactant_protein_A	29,49	SP-A	51,55	surfactant protein A	SP-A	653509	24773(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Specific interaction of lung surfactant_protein_A -LRB- SP-A -RRB- with rat alveolar macrophages .
18581277	0	surfactant_protein_A	46,66	SP-A	68,72	surfactant protein A	SP-A	653509	653509	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Histological findings and immunohistochemical surfactant_protein_A -LRB- SP-A -RRB- expression in asphyxia : its application in the diagnosis of drowning .
21402781	0	surfactant_protein_A	25,45	SP-A	52,56	surfactant protein A	SP-A	653509	653509	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Epigenetic regulation of surfactant_protein_A gene -LRB- SP-A -RRB- expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia .
23328842	0	surfactant_protein_A	99,119	SP-A	121,125	surfactant protein A	SP-A	653509	653509	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant_protein_A -LRB- SP-A -RRB- gene .
24007361	0	surfactant_protein_A	37,57	SP-A	59,63	surfactant protein A	SP-A	653509	653509	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pilot study exploring lung allograft surfactant_protein_A -LRB- SP-A -RRB- expression in association with lung transplant outcome .
7532637	0	surfactant_protein_A	16,36	SP-A	38,42	surfactant protein A	SP-A	24773(Tax:10116)	24773(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of surfactant_protein_A -LRB- SP-A -RRB- in alveolar_macrophage subpopulations of normal and fibrotic rat lung .
7896788	0	surfactant_protein_A	44,64	SP-A	66,70	surfactant protein A	SP-A	20387(Tax:10090)	20387(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lung cell-specific expression of the murine surfactant_protein_A -LRB- SP-A -RRB- gene is mediated by interactions between the SP-A promoter and thyroid_transcription_factor-1 .
1930130	0	surfactant_protein_A	65,85	Surfactant_protein_D	0,20	surfactant protein A	Surfactant protein D	24773(Tax:10116)	25350(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY counteracts|dobj|effect counteracts|nsubj|END_ENTITY	Surfactant_protein_D -LRB- SP-D -RRB- counteracts the inhibitory effect of surfactant_protein_A -LRB- SP-A -RRB- on phospholipid secretion by alveolar type II cells .
1536863	0	surfactant_protein_A	41,61	Transforming_growth_factor-beta	0,31	surfactant protein A	Transforming growth factor-beta	653509	7040	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits surfactant_protein_A expression in vitro .
18407667	0	surfactant_protein_A	15,35	desmin	68,74	surfactant protein A	desmin	653509	1674	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of surfactant_protein_A with the intermediate filaments desmin and vimentin .
16087679	0	surfactant_protein_A	22,42	myosin	78,84	surfactant protein A	myosin	653509	79784	Gene	Gene	receptor|compound|START_ENTITY Identification|nmod|receptor 210|nsubj|Identification 210|nmod|18A 18A|amod|END_ENTITY	Identification of the surfactant_protein_A receptor 210 as the unconventional myosin 18A .
7946398	0	surfactant_protein_A	15,35	myosin	50,56	surfactant protein A	myosin	653509	79784	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of surfactant_protein_A with cellular myosin .
16330552	0	surfactant_protein_A	15,35	phospholipase_A2	67,83	surfactant protein A	phospholipase A2	653509	151056	Gene	Gene	Interaction|nmod|START_ENTITY regulates|nsubj|Interaction regulates|dobj|activity activity|amod|END_ENTITY	Interaction of surfactant_protein_A with peroxiredoxin_6 regulates phospholipase_A2 activity .
24438626	0	surfactant_protein_A	10,30	tumor_necrosis_factor-a	61,84	surfactant protein A	tumor necrosis factor-a	653509	7124	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of surfactant_protein_A on lipopolysaccharide-induced tumor_necrosis_factor-a expression in human proximal tubular epithelial cells .
20036966	0	surfactant_protein_A_and_D	8,34	SP-A	36,40	surfactant protein A and D	SP-A	653509;6441	653509	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of surfactant_protein_A_and_D -LRB- SP-A and SP-D -RRB- in human antiviral host defense .
18256027	0	surfactant_protein_B	39,59	Pepsinogen_C	0,12	surfactant protein B	Pepsinogen C	6439	5225	Gene	Gene	processing|nmod|START_ENTITY processing|amod|END_ENTITY	Pepsinogen_C proteolytic processing of surfactant_protein_B .
1850607	0	surfactant_protein_B	24,44	SP-B	46,50	surfactant protein B	SP-B	192155(Tax:10116)	192155(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Hormonal effects on the surfactant_protein_B -LRB- SP-B -RRB- mRNA in cultured fetal rat lung .
23272120	0	surfactant_protein_B	68,88	SP-B	90,94	surfactant protein B	SP-B	6439	6439	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	Synergistic effect of caffeine and glucocorticoids on expression of surfactant_protein_B -LRB- SP-B -RRB- mRNA .
9006959	0	surfactant_protein_B	23,43	SP-B	45,49	surfactant protein B	SP-B	6439	6439	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Functional analysis of surfactant_protein_B -LRB- SP-B -RRB- promoter .
11788590	0	surfactant_protein_B	35,55	STAT3	64,69	surfactant protein B	STAT3	6439	6774	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional stimulation of the surfactant_protein_B gene by STAT3 in respiratory epithelial cells .
12161428	0	surfactant_protein_B	51,71	Transforming_growth_factor-beta	0,31	surfactant protein B	Transforming growth factor-beta	6439	7040	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta inhibits pulmonary surfactant_protein_B gene transcription through SMAD3 interactions with NKX2 .1 and HNF-3 transcription factors .
18400946	0	surfactant_protein_C	99,119	ERdj4	0,5	surfactant protein C	ERdj4	6440	4189	Gene	Gene	degradation|nmod|START_ENTITY required|nmod|degradation required|nsubjpass|END_ENTITY	ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant_protein_C .
21707890	1	surfactant_protein_C	220,240	SFTPC	242,247	surfactant protein C	hSP-C	6440	6440	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interstitial_lung_disease in both children and adults has been linked to mutations in the lung-specific surfactant_protein_C -LRB- SFTPC -RRB- gene .
24347240	0	surfactant_protein_C	38,58	SFTPC	60,65	surfactant protein C	SFTPC	6440	6440	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Survival of an infant with homozygous surfactant_protein_C -LRB- SFTPC -RRB- mutation .
14742512	0	surfactant_protein_D	63,83	SP-D	85,89	surfactant protein D	SP-D	6441	6441	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding and agglutination of Streptococcus_pneumoniae by human surfactant_protein_D -LRB- SP-D -RRB- vary between strains , but SP-D fails to enhance killing by neutrophils .
1527377	0	surfactant_protein_D	35,55	SP-D	57,61	surfactant protein D	SP-D	25350(Tax:10116)	25350(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of surfactant_protein_D -LRB- SP-D -RRB- in type II cells , Clara cells , and alveolar macrophages of rat lung .
25134376	0	surfactant_protein_D	24,44	SP-D	46,50	surfactant protein D	SP-D	6441	6441	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	The evaluation of serum surfactant_protein_D -LRB- SP-D -RRB- levels as a biomarker of lung_injury in tuberculosis and different lung_diseases .
15173172	0	surfactant_protein_D	67,87	Sftpd	94,99	surfactant protein D	Sftpd	20390(Tax:10090)	20390(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Nuclear factor of activated T cells regulates transcription of the surfactant_protein_D gene -LRB- Sftpd -RRB- via direct interaction with thyroid_transcription_factor-1 in lung epithelial cells .
11355171	0	surfactant_protein_D	56,76	T-cadherin	0,10	surfactant protein D	T-cadherin	6441	1012	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	T-cadherin -LRB- CDH13 , H-cadherin -RRB- expression downregulated surfactant_protein_D in bronchioloalveolar cells .
25782381	0	surfactant_protein_D	93,113	interleukin-13	64,78	surfactant protein D	interleukin-13	6441	3596	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Expression of surfactant_protein_D in airways of asthmatics and interleukin-13 modulation of surfactant_protein_D in human models of airway epithelium .
25848896	0	surfactant_protein_D	93,113	interleukin-13	64,78	surfactant protein D	interleukin-13	6441	3596	Gene	Gene	modulation|nmod|START_ENTITY modulation|amod|END_ENTITY	Expression of surfactant_protein_D in airways of asthmatics and interleukin-13 modulation of surfactant_protein_D in human models of airway epithelium .
17567900	0	surfactant_protein_D	29,49	mannose_binding_lectin	61,83	surfactant protein D	mannose binding lectin	6441	4153	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	AIDS patients have increased surfactant_protein_D but normal mannose_binding_lectin levels in lung fluid .
10632746	0	surfactant_proteins_A_and_B	142,169	Thyroid_transcription_factor-1	0,30	surfactant proteins A and B	Thyroid transcription factor-1	6439;653509	7080	Gene	Gene	marker|acl|START_ENTITY marker|nsubj|END_ENTITY	Thyroid_transcription_factor-1 is the superior immunohistochemical marker for pulmonary_adenocarcinomas and large_cell_carcinomas compared to surfactant_proteins_A_and_B .
10734235	0	survival_motor_neuron	4,25	FUSE_binding_protein	68,88	survival motor neuron	FUSE binding protein	6606	8880	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The survival_motor_neuron protein interacts with the transactivator FUSE_binding_protein from human fetal brain .
10749974	0	survival_motor_neuron	74,95	SMN	97,100	survival motor neuron	SMN	6606	6606	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Characterization of the Schizosaccharomyces_pombe orthologue of the human survival_motor_neuron -LRB- SMN -RRB- protein .
11085591	0	survival_motor_neuron	4,25	SMN	27,30	survival motor neuron	SMN	6606	6606	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The survival_motor_neuron -LRB- SMN -RRB- protein : effect of exon loss and mutation on protein localization .
14742439	0	survival_motor_neuron	124,145	SMN	147,150	survival motor neuron	SMN	6606	6606	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel cyclic_AMP-response element -LRB- CRE-II -RRB- and the role of CREB-1 in the cAMP-induced expression of the survival_motor_neuron -LRB- SMN -RRB- gene .
15361068	0	survival_motor_neuron	24,45	SMN	47,50	survival motor neuron	SMN	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Characterization of the survival_motor_neuron -LRB- SMN -RRB- promoter provides evidence for complex combinatorial regulation in undifferentiated and differentiated P19 cells .
21082361	0	survival_motor_neuron	17,38	SMN	40,43	survival motor neuron	SMN	6606	6606	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Mutations in the survival_motor_neuron -LRB- SMN -RRB- protein alter the dynamic nature of nuclear bodies .
9600994	0	survival_motor_neuron	74,95	SMN	97,100	survival motor neuron	SMN	6606	6606	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Heterogeneity of subcellular localization and electrophoretic mobility of survival_motor_neuron -LRB- SMN -RRB- protein in mammalian neural cells and tissues .
15586177	0	survival_motor_neuron	53,74	SMN1	76,80	survival motor neuron	SMN1	6606	6606	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Somatic mosaicism for a heterozygous deletion of the survival_motor_neuron -LRB- SMN1 -RRB- gene .
12952942	0	survival_motor_neuron	17,38	Smn	40,43	survival motor neuron	Smn	30432(Tax:7955)	30432(Tax:7955)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Knockdown of the survival_motor_neuron -LRB- Smn -RRB- protein in zebrafish causes defects in motor axon outgrowth and pathfinding .
9070939	0	survival_motor_neuron	70,91	Smn	98,101	survival motor neuron	Smn	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	cDNA isolation , expression , and chromosomal localization of the mouse survival_motor_neuron gene -LRB- Smn -RRB- .
18794368	0	survival_motor_neuron_2	75,98	SMN2	100,104	survival motor neuron 2	SMN2	6607	6607	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The RNA binding protein hnRNP_Q modulates the utilization of exon 7 in the survival_motor_neuron_2 -LRB- SMN2 -RRB- gene .
15767679	0	survival_motor_neurons	71,93	SMN	95,98	survival motor neurons	SMN	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	ZPR1 is essential for survival and is required for localization of the survival_motor_neurons -LRB- SMN -RRB- protein to Cajal bodies .
11181573	0	survival_of_motor_neuron	17,41	SMN	43,46	survival of motor neuron	SMN	6606	6606	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Co-regulation of survival_of_motor_neuron -LRB- SMN -RRB- protein and its interactor SIP1 during development and in spinal_muscular_atrophy .
12030329	0	survival_of_motor_neuron	18,42	SMN	44,47	survival of motor neuron	SMN	64301(Tax:10116)	64301(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the survival_of_motor_neuron -LRB- SMN -RRB- gene in primary neurons and increase in SMN levels by activation of the N-methyl-D-aspartate_glutamate receptor .
12221125	0	survival_of_motor_neuron	19,43	SMN	45,48	survival of motor neuron	SMN	6606	6606	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The product of the survival_of_motor_neuron -LRB- SMN -RRB- gene is a human telomerase-associated protein .
14697339	0	survival_of_motor_neuron	72,96	SMN	98,101	survival of motor neuron	SMN	6606	6606	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Ultrastructural characterisation of a nuclear domain highly enriched in survival_of_motor_neuron -LRB- SMN -RRB- protein .
20826664	0	survival_of_motor_neuron	8,32	SMN	34,37	survival of motor neuron	SMN	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Reduced survival_of_motor_neuron -LRB- SMN -RRB- protein in motor neuronal progenitors functions cell autonomously to cause spinal_muscular_atrophy in model mice expressing the human centromeric -LRB- SMN2 -RRB- gene .
23897586	0	survival_of_motor_neuron	12,36	SMN	38,41	survival of motor neuron	SMN	20595(Tax:10090)	20595(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Dynamics of survival_of_motor_neuron -LRB- SMN -RRB- protein interaction with the mRNA-binding protein IMP1 facilitates its trafficking into motor neuron axons .
10942426	0	survival_of_motor_neurons	57,82	SMN	84,87	survival of motor neurons	SMN	6606	6606	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Characterization of a nuclear 20S complex containing the survival_of_motor_neurons -LRB- SMN -RRB- protein and a specific subset of spliceosomal Sm proteins .
11509230	0	survival_of_motor_neurons	4,29	fibrillarin	79,90	survival of motor neurons	fibrillarin	6606	2091	Gene	Gene	protein|compound|START_ENTITY interacts|nsubj|protein interacts|nmod|END_ENTITY	The survival_of_motor_neurons -LRB- SMN -RRB- protein interacts with the snoRNP proteins fibrillarin and GAR1 .
11581300	0	survivin	25,33	p53	113,116	survivin	p53	11799(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY counteracts|nsubj|expression counteracts|nmod|loss loss|nmod|END_ENTITY	Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53 .
16585159	0	survivin	20,28	p53	71,74	survivin	p53	11799(Tax:10090)	22060(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Mitosis-independent survivin gene expression in vivo and regulation by p53 .
15729715	0	survivin	30,38	tax	107,110	survivin	tax	11799(Tax:10090)	1491938(Tax:11908)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|pathway pathway|nmod|END_ENTITY	Transcriptional activation of survivin through the NF-kappaB pathway by human_T-cell_leukemia_virus_type_I tax .
20947812	0	survivor_motor_neuron_2	20,43	SMN2	45,49	survivor motor neuron 2	SMN2	6607	6607	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between survivor_motor_neuron_2 -LRB- SMN2 -RRB- gene homozygous deletion and sporadic lower_motor_neuron_disease in a Korean population .
23131994	0	sushi_domain_containing_2	22,47	SUSD2	49,54	sushi domain containing 2	SUSD2	71733(Tax:10090)	71733(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Multiple functions of sushi_domain_containing_2 -LRB- SUSD2 -RRB- in breast tumorigenesis .
19795139	0	synapse-associated_protein_102	47,77	DLG3	24,28	synapse-associated protein 102	DLG3	1741	1741	Gene	Gene	encoding|dobj|START_ENTITY gene|acl|encoding gene|compound|END_ENTITY	A novel mutation in the DLG3 gene encoding the synapse-associated_protein_102 -LRB- SAP102 -RRB- causes non-syndromic_mental_retardation .
12070168	0	synapse-associated_protein_97	21,50	GluR-A	54,60	synapse-associated protein 97	GluR-A	1739	2890	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Selective binding of synapse-associated_protein_97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole_propionate receptor subunit is determined by a novel sequence motif .
18665322	0	synapse-associated_protein_97	27,56	SAP97	58,63	synapse-associated protein 97	SAP97	1739	1739	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An association analysis of synapse-associated_protein_97 -LRB- SAP97 -RRB- gene in schizophrenia .
22225629	0	synapse-associated_protein_97	61,90	SAP97	92,97	synapse-associated protein 97	SAP97	1739	1739	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Further evidence for a male-selective genetic association of synapse-associated_protein_97 -LRB- SAP97 -RRB- gene with schizophrenia .
3130468	0	synapsin_I	30,40	P38	68,71	synapsin I	P38	6853	1432	Gene	Gene	START_ENTITY|appos|protein protein|nummod|END_ENTITY	The synaptic vesicle proteins synapsin_I and synaptophysin -LRB- protein P38 -RRB- are concentrated both in efferent and afferent nerve endings of the skeletal muscle .
23250796	0	synapsin_I	56,66	SYN1	73,77	synapsin I	SYN1	20964(Tax:10090)	20964(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Specificity_protein_1 -LRB- Sp1 -RRB- - dependent activation of the synapsin_I gene -LRB- SYN1 -RRB- is modulated by RE1-silencing_transcription_factor -LRB- REST -RRB- and 5 ' - cytosine-phosphoguanine -LRB- CpG -RRB- methylation .
16963290	0	synapsin_I	70,80	Sim2	29,33	synapsin I	Sim2	24949(Tax:10116)	304071(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of overexpression of Sim2 on spatial memory and expression of synapsin_I in rat hippocampus .
7587399	0	synapsin_II	11,22	SYN2	24,28	synapsin II	SYN2	6854	6854	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Mapping of synapsin_II -LRB- SYN2 -RRB- genes to human chromosome 3p and mouse chromosome 6 band F. Synapsins are neuron-specific phosphoproteins of small synaptic vesicles encoded by two different genes .
19013223	0	synaptic_vesicle-2-associated_protein	26,63	Msvop	65,70	synaptic vesicle-2-associated protein	Msvop	734235(Tax:8355)	68666(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of mouse synaptic_vesicle-2-associated_protein -LRB- Msvop -RRB- specifically expressed in the mouse central nervous system .
11748641	0	synaptic_vesicle_protein_2	14,40	SV2	42,45	synaptic vesicle protein 2	SV2	9900	9900	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of synaptic_vesicle_protein_2 -LRB- SV2 -RRB- in neuroendocrine_tumours of the gastrointestinal tract and pancreas .
19751703	0	synaptic_vesicle_protein_2A	41,68	SV2A	70,74	synaptic vesicle protein 2A	SV2A	64051(Tax:10090)	64051(Tax:10090)	Gene	Gene	increase|nmod|START_ENTITY increase|appos|END_ENTITY	Preferential increase in the hippocampal synaptic_vesicle_protein_2A -LRB- SV2A -RRB- by pentylenetetrazole kindling .
19357284	0	synaptogyrin-3	102,116	dopamine_transporter	48,68	synaptogyrin-3	dopamine transporter	20974(Tax:10090)	13162(Tax:10090)	Gene	Gene	interaction|amod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction between the dopamine_transporter and the synaptic vesicle protein synaptogyrin-3 .
21932368	0	synaptojanin-1	59,73	NAP-22	21,27	synaptojanin-1	NAP-22	8867	10409	Gene	Gene	activity|nmod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Inhibitory effect of NAP-22 on the phosphatase activity of synaptojanin-1 .
14704270	0	synaptojanin_1	14,28	cyclin-dependent_kinase_5	32,57	synaptojanin 1	cyclin-dependent kinase 5	8867	1020	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of synaptojanin_1 by cyclin-dependent_kinase_5 at synapses .
22670862	0	synaptonemal_complex_protein_3	34,64	SYCP3	66,71	synaptonemal complex protein 3	SYCP3	50511	50511	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Investigation of mutations in the synaptonemal_complex_protein_3 -LRB- SYCP3 -RRB- gene among azoospermic infertile male patients in the Turkish population .
19019428	0	synaptophysin	30,43	Nerve_growth_factor	0,19	synaptophysin	Nerve growth factor	24804(Tax:10116)	310738(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nerve_growth_factor regulates synaptophysin expression in developing trigeminal_ganglion neurons in vitro .
12492469	0	synaptophysin	59,72	RE-1_silencing_transcription_factor	0,35	synaptophysin	RE-1 silencing transcription factor	6855	5978	Gene	Gene	transcription|compound|START_ENTITY regulates|dobj|transcription regulates|nsubj|END_ENTITY	RE-1_silencing_transcription_factor -LRB- REST -RRB- regulates human synaptophysin gene transcription through an intronic sequence-specific DNA-binding site .
25755825	0	synaptophysin	41,54	Siah-1	20,26	synaptophysin	Siah-1	6855	6477	Gene	Gene	expression|compound|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	E3 ubiquitin ligase Siah-1 downregulates synaptophysin expression under high glucose and hypoxia .
7848269	0	synaptophysin	77,90	Vesicle-associated_membrane_protein-2	0,37	synaptophysin	Vesicle-associated membrane protein-2	6855	6844	Gene	Gene	complex|nmod|START_ENTITY forms|dobj|complex forms|nsubj|END_ENTITY	Vesicle-associated_membrane_protein-2 -LRB- synaptobrevin-2 -RRB- forms a complex with synaptophysin .
17585539	0	synaptophysin	59,72	chromogranin_A	18,32	synaptophysin	chromogranin A	6855	1113	Gene	Gene	product|dep|START_ENTITY product|compound|END_ENTITY	Selected markers -LRB- chromogranin_A , neuron-specific_enolase , synaptophysin , protein gene product 9.5 -RRB- in diagnosis and prognosis of neuroendocrine_pulmonary_tumours .
12498786	0	synaptophysin	15,28	gamma-adaptin	59,72	synaptophysin	gamma-adaptin	6855	164	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin .
18829074	0	synaptophysin	40,53	p38	63,66	synaptophysin	p38	6855	1432	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	The immunohistochemical localization of synaptophysin protein -LRB- p38 -RRB- in the gastro-entero-pancreatic _ -LRB- GEP -RRB- _ system of reptiles .
1908264	0	synaptophysin	35,48	p38	58,61	synaptophysin	p38	24804(Tax:10116)	81649(Tax:10116)	Gene	Gene	START_ENTITY|appos|protein protein|nummod|END_ENTITY	Immunocytochemical localization of synaptophysin -LRB- protein p38 -RRB- and synapsin_I in nerve terminals of rat neurohypophysis .
2115313	0	synaptophysin	36,49	p38	51,54	synaptophysin	p38	6855	1432	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of synaptophysin -LRB- p38 -RRB- in the pineal gland of the Mongolian gerbil -LRB- Meriones unguiculatus -RRB- .
3139837	0	synaptophysin	19,32	p38	42,45	synaptophysin	p38	24804(Tax:10116)	81649(Tax:10116)	Gene	Gene	START_ENTITY|appos|protein protein|nummod|END_ENTITY	In adrenal medulla synaptophysin -LRB- protein p38 -RRB- is present in chromaffin granules and in a special vesicle population .
8102940	0	synaptophysin	32,45	p38	56,59	synaptophysin	p38	24804(Tax:10116)	81649(Tax:10116)	Gene	Gene	immunoreactivity|nmod|START_ENTITY Changes|nmod|immunoreactivity Changes|dep|protein protein|nummod|END_ENTITY	Changes of immunoreactivity for synaptophysin -LRB- ` protein p38 ' -RRB- following a transient cerebral_ischemia in the rat striatum .
8213090	0	synaptophysin	63,76	p38	86,89	synaptophysin	p38	24804(Tax:10116)	81649(Tax:10116)	Gene	Gene	START_ENTITY|appos|protein protein|nummod|END_ENTITY	Distinct neuronal subset reveals perikaryal immunostaining for synaptophysin -LRB- protein p38 -RRB- in the striatum of rats .
1918133	0	synaptophysin	18,31	transferrin	37,48	synaptophysin	transferrin	6855	7018	Gene	Gene	START_ENTITY|nmod|receptors receptors|compound|END_ENTITY	Colocalization of synaptophysin with transferrin receptors : implications for synaptic vesicle biogenesis .
11696420	0	synaptopodin	12,24	Myopodin	0,8	synaptopodin	Myopodin	11346	171024	Gene	Gene	homologue|compound|START_ENTITY END_ENTITY|appos|homologue	Myopodin , a synaptopodin homologue , is frequently deleted in invasive prostate_cancers .
16777346	0	synaptoporin	106,118	synaptoporin	27,39	synaptoporin	synaptoporin	66030(Tax:10116)	66030(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral_nerve_injury .
16777346	0	synaptoporin	27,39	synaptoporin	106,118	synaptoporin	synaptoporin	66030(Tax:10116)	66030(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of synaptoporin and synaptophysin in primary sensory neurons and up-regulation of synaptoporin after peripheral_nerve_injury .
9639508	0	synaptosomal-associated_protein-23_kD	13,50	SNAP-23	52,59	synaptosomal-associated protein-23 kD	SNAP-23	8773	8773	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of synaptosomal-associated_protein-23_kD -LRB- SNAP-23 -RRB- by various cytokines .
19482079	0	synaptosomal-associated_protein_25	19,53	SNAP-25	55,62	synaptosomal-associated protein 25	SNAP-25	25012(Tax:10116)	25012(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Gene expression of synaptosomal-associated_protein_25 -LRB- SNAP-25 -RRB- in the prefrontal cortex of the spontaneously hypertensive rat -LRB- SHR -RRB- .
22311984	0	synaptosomal-associated_protein_25	76,110	SNAP-25	112,119	synaptosomal-associated protein 25	SNAP-25	25012(Tax:10116)	25012(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Phospholipase_C-related_but_catalytically_inactive_protein -LRB- PRIP -RRB- modulates synaptosomal-associated_protein_25 -LRB- SNAP-25 -RRB- phosphorylation and exocytosis .
23135794	0	synaptosomal-associated_protein_25	44,78	Snap25	80,86	synaptosomal-associated protein 25	Snap25	25012(Tax:10116)	25012(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental and diurnal expression of the synaptosomal-associated_protein_25 -LRB- Snap25 -RRB- in the rat pineal gland .
20333500	0	synaptosomal_protein	22,42	SNAP-25	44,51	synaptosomal protein	SNAP-25	6616	6616	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association between a synaptosomal_protein -LRB- SNAP-25 -RRB- gene polymorphism and verbal memory and attention in patients with endogenous psychoses and mentally healthy subjects .
9712836	0	synaptotagmin-1	76,91	fibroblast_growth_factor-1	41,67	synaptotagmin-1	fibroblast growth factor-1	20979(Tax:10090)	14164(Tax:10090)	Gene	Gene	release|amod|START_ENTITY release|amod|END_ENTITY	S100A13 is involved in the regulation of fibroblast_growth_factor-1 and p40 synaptotagmin-1 release in vitro .
11502761	0	synaptotagmin_1	24,39	AP2	4,7	synaptotagmin 1	AP2	25716(Tax:10116)	79451(Tax:10116)	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	The AP2 binding site of synaptotagmin_1 is not an internalization signal but a regulator of endocytosis .
19632983	0	synaptotagmin_1	21,36	Ca2	4,7	synaptotagmin 1	Ca2	6857	760	Gene	Gene	affinity|nmod|START_ENTITY affinity|amod|END_ENTITY	The Ca2 + affinity of synaptotagmin_1 is markedly increased by a specific interaction of its C2B domain with phosphatidylinositol_4 ,5 - bisphosphate .
15466855	0	synaptotagmin_1	15,30	SV2B	0,4	synaptotagmin 1	SV2B	20979(Tax:10090)	64176(Tax:10090)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	SV2B regulates synaptotagmin_1 by direct interaction .
15350218	0	synaptotagmin_2	20,35	WNK1	0,4	synaptotagmin 2	WNK1	127833	65125	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	WNK1 phosphorylates synaptotagmin_2 and modulates its membrane binding .
11805296	0	synaptotagmin_I	96,111	C2B	82,85	synaptotagmin I	C2B	6857	100130342	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	C2A activates a cryptic Ca -LRB- 2 + -RRB- - triggered membrane penetration activity within the C2B domain of synaptotagmin_I .
15056279	0	synaptotagmin_I	69,84	C2B	47,50	synaptotagmin I	C2B	6857	100130342	Gene	Gene	variant|nmod|START_ENTITY splice|dobj|variant splice|nsubj|Identification Identification|nmod|END_ENTITY	Identification and characterization of a novel C2B splice variant of synaptotagmin_I .
15456828	0	synaptotagmin_I	32,47	C2B	18,21	synaptotagmin I	C2B	20979(Tax:10090)	233090(Tax:10090)	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Dual roles of the C2B domain of synaptotagmin_I in synchronizing Ca2 + - dependent neurotransmitter release .
22475172	0	synaptotagmin_I	83,98	C2B	63,66	synaptotagmin I	C2B	6857	100130342	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|domain domain|compound|END_ENTITY	Molecular level interaction of inositol_hexaphosphate with the C2B domain of human synaptotagmin_I .
9144250	0	synaptotagmin_I	80,95	C2B	66,69	synaptotagmin I	C2B	6857	100130342	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Interaction of the synprint site of N-type Ca2 + channels with the C2B domain of synaptotagmin_I .
19631636	0	syndecan	6,14	SDN-1	0,5	syndecan	SDN-1	181259(Tax:6239)	181259(Tax:6239)	Gene	Gene	regulates|nsubj|START_ENTITY END_ENTITY|appos|regulates	SDN-1 / syndecan regulates growth factor signaling in distal tip cell migrations in C. _ elegans .
16280658	0	syndecan-1	11,21	CD138	23,28	syndecan-1	CD138	6382	6382	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Utility of syndecan-1 -LRB- CD138 -RRB- expression in the diagnosis of undifferentiated malignant_neoplasms : a tissue microarray study of 1,754 cases .
19342678	0	syndecan-1	41,51	CD138	53,58	syndecan-1	CD138	20969(Tax:10090)	20969(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the heparan sulfate proteoglycan syndecan-1 -LRB- CD138 -RRB- in delayed-type_hypersensitivity .
19860843	0	syndecan-1	8,18	CD138	20,25	syndecan-1	CD138	6382	6382	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of syndecan-1 -LRB- CD138 -RRB- in cell survival of human urothelial_carcinoma .
21334435	0	syndecan-1	59,69	Extracellular_superoxide_dismutase	0,34	syndecan-1	Extracellular superoxide dismutase	20969(Tax:10090)	20657(Tax:10090)	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Extracellular_superoxide_dismutase protects cardiovascular syndecan-1 from oxidative shedding .
22912899	0	syndecan-1	50,60	PDGF-B	14,20	syndecan-1	PDGF-B	20969(Tax:10090)	18591(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase , Topors .
9409233	0	syndecan-1	20,30	Thrombin	0,8	syndecan-1	Thrombin	25216(Tax:10116)	29251(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Thrombin stimulates syndecan-1 promotor activity and expression of a form of syndecan-1 that binds antithrombin_III in vascular smooth muscle cells .
12652971	0	syndecan-1	38,48	heparan_sulfate_proteoglycan	8,36	syndecan-1	heparan sulfate proteoglycan	482986(Tax:9615)	25216(Tax:10116)	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of heparan_sulfate_proteoglycan -LRB- syndecan-1 -RRB- on the renal epithelial cells during calcium_oxalate monohydrate crystal attachment .
11830493	0	syndecan-1	26,36	hepatocyte_growth_factor	46,70	syndecan-1	hepatocyte growth factor	6382	3082	Gene	Gene	mediates|amod|START_ENTITY END_ENTITY|nsubj|mediates	Cell surface proteoglycan syndecan-1 mediates hepatocyte_growth_factor binding and promotes Met signaling in multiple_myeloma .
14527339	0	syndecan-2	23,33	Interleukin-8	0,13	syndecan-2	Interleukin-8	6383	3576	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Interleukin-8 binds to syndecan-2 on human endothelial cells .
22493442	0	syndecan-2	73,83	Melanocortin_1_receptor	0,23	syndecan-2	Melanocortin 1 receptor	15529(Tax:10090)	17199(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|nmod|expression regulates|nsubj|END_ENTITY	Melanocortin_1_receptor regulates melanoma cell migration by controlling syndecan-2 expression .
10446183	0	syndecan-2	70,80	fibroglycan	82,93	syndecan-2	fibroglycan	6383	6383	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Inducible expression of the cell surface heparan sulfate proteoglycan syndecan-2 -LRB- fibroglycan -RRB- on human activated macrophages can regulate fibroblast growth factor action .
24613844	0	syndecan-2	50,60	matrix_metalloproteinase-7	78,104	syndecan-2	matrix metalloproteinase-7	6383	4316	Gene	Gene	START_ENTITY|nmod|induction induction|nmod|expression expression|amod|END_ENTITY	Interleukin-1a promotes extracellular shedding of syndecan-2 via induction of matrix_metalloproteinase-7 expression .
16226436	0	syndecan-3	40,50	BMP	60,63	syndecan-3	BMP	9672	649	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation .
21200028	0	syndecan-3	29,39	GDNF	64,68	syndecan-3	GDNF	20970(Tax:10090)	14573(Tax:10090)	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF , neurturin , and artemin .
15033938	0	syndecan-4	2,12	CXCR4	13,18	syndecan-4	CXCR4	6385	7852	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	A syndecan-4 / CXCR4 complex expressed on human primary lymphocytes and macrophages and HeLa cell line binds the CXC chemokine stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- .
15694365	0	syndecan-4	26,36	Dynamin_II	0,10	syndecan-4	Dynamin II	6385	1785	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dynamin_II interacts with syndecan-4 , a regulator of focal adhesion and stress-fiber formation .
21939780	0	syndecan-4	70,80	Fibroblast_growth_factor_2	0,26	syndecan-4	Fibroblast growth factor 2	100126249(Tax:9103)	100550388	Gene	Gene	modulation|amod|START_ENTITY involved|nmod|modulation involved|nsubjpass|END_ENTITY	Fibroblast_growth_factor_2 and protein_kinase_C_alpha are involved in syndecan-4 cytoplasmic domain modulation of turkey myogenic satellite cell proliferation .
21949132	0	syndecan-4	136,146	TNF-a	0,5	syndecan-4	TNF-a	6385	7124	Gene	Gene	promote|nmod|START_ENTITY promote|nsubj|END_ENTITY	TNF-a and IL-1b promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc .
23576453	0	syndecan-4	24,34	TNF-a	51,56	syndecan-4	TNF-a	6385	7124	Gene	Gene	upregulation|amod|START_ENTITY mechanisms|nmod|upregulation mechanisms|nmod|END_ENTITY	Molecular mechanisms of syndecan-4 upregulation by TNF-a in the endothelium-like EAhy926 cells .
25449226	0	syndecan-4	34,44	Transglutaminase_2	0,18	syndecan-4	Transglutaminase 2	6385	7052	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Transglutaminase_2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells .
18753452	0	syndecan-4	71,81	fibroblast_growth_factor_2	14,40	syndecan-4	fibroblast growth factor 2	100126249(Tax:9103)	100550388	Gene	Gene	expression|acl|START_ENTITY END_ENTITY|nmod|expression	The effect of fibroblast_growth_factor_2 on the in vitro expression of syndecan-4 and glypican-1 in turkey satellite cells .
23772770	0	syndecan-4	103,113	fibroblast_growth_factor_2	43,69	syndecan-4	fibroblast growth factor 2	100126249(Tax:9103)	100550388	Gene	Gene	age|amod|START_ENTITY Changes|nmod|age Changes|nmod|responsiveness responsiveness|amod|END_ENTITY	Changes in proliferation , differentiation , fibroblast_growth_factor_2 responsiveness and expression of syndecan-4 and glypican-1 with turkey satellite cell age .
24235146	0	syndecan-4	159,169	syntenin	170,178	syndecan-4	syntenin	20971(Tax:10090)	53378(Tax:10090)	Gene	Gene	pathways|amod|START_ENTITY pathways|compound|END_ENTITY	Angiopoietin-2 secretion by endothelial cell exosomes : regulation by the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt/endothelial _ nitric_oxide_synthase -LRB- eNOS -RRB- and syndecan-4 / syntenin pathways .
23137022	0	syndecan_1	39,49	CD138	51,56	syndecan 1	CD138	6382	6382	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Hepatic expression and serum levels of syndecan_1 -LRB- CD138 -RRB- in patients with nonalcoholic_fatty_liver_disease .
8344959	0	syndecan_3	12,22	basic_fibroblast_growth_factor	54,84	syndecan 3	basic fibroblast growth factor	116673(Tax:10116)	54250(Tax:10116)	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	N-syndecan -LRB- syndecan_3 -RRB- from neonatal rat brain binds basic_fibroblast_growth_factor .
12971991	0	synembryn	21,30	ric-8	14,19	synembryn	ric-8	101489(Tax:10090)	101489(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Expression of ric-8 -LRB- synembryn -RRB- gene in the nervous system of developing and adult mouse .
7738119	0	synexin	44,51	annexin_VII	31,42	synexin	annexin VII	310	310	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of annexin_VII -LRB- synexin -RRB- in muscle cells .
19762560	0	synphilin-1	17,28	alpha-synuclein	61,76	synphilin-1	alpha-synuclein	9627	6622	Gene	Gene	formation|amod|START_ENTITY formation|nmod|END_ENTITY	Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein : mechanistic insights and pathological implication .
8730101	0	syntaxin	6,14	Pep12p	26,32	syntaxin	Pep12p	851219(Tax:4932)	854201(Tax:4932)	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Novel syntaxin homologue , Pep12p , required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast .
11432826	0	syntaxin	22,30	Tlg2p	41,46	syntaxin	Tlg2p	851219(Tax:4932)	854142(Tax:4932)	Gene	Gene	START_ENTITY|acl|homologue homologue|dobj|END_ENTITY	Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation .
11460165	0	syntaxin	16,24	UNC-13	54,60	syntaxin	UNC-13	172663(Tax:6239)	172497(Tax:6239)	Gene	Gene	form|nmod|START_ENTITY bypasses|nsubj|form bypasses|dobj|requirement requirement|nmod|END_ENTITY	An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming .
16271476	0	syntaxin	24,32	UNC-13	0,6	syntaxin	UNC-13	172663(Tax:6239)	172497(Tax:6239)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	UNC-13 interaction with syntaxin is required for synaptic transmission .
9506516	0	syntaxin	52,60	Ufe1p	69,74	syntaxin	Ufe1p	851219(Tax:4932)	854242(Tax:4932)	Gene	Gene	START_ENTITY|acl|homolog homolog|dobj|END_ENTITY	Organelle membrane fusion : a novel function for the syntaxin homolog Ufe1p in ER membrane fusion .
11432826	0	syntaxin	22,30	Vps45p	0,6	syntaxin	Vps45p	851219(Tax:4932)	852785(Tax:4932)	Gene	Gene	stabilizes|dobj|START_ENTITY stabilizes|nsubj|END_ENTITY	Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation .
17496234	0	syntaxin-1A	107,118	sulfonylurea_receptor_1	129,152	syntaxin-1A	sulfonylurea receptor 1	116470(Tax:10116)	25559(Tax:10116)	Gene	Gene	acting|amod|START_ENTITY acting|nmod|END_ENTITY	The actions of a novel potent islet beta-cell specific ATP-sensitive K + channel opener can be modulated by syntaxin-1A acting on sulfonylurea_receptor_1 .
19033398	0	syntaxin-4	15,25	DOC2B	0,5	syntaxin-4	DOC2B	6810	8447	Gene	Gene	protein|amod|START_ENTITY END_ENTITY|dep|protein	DOC2B : a novel syntaxin-4 binding protein mediating insulin-regulated GLUT4 vesicle fusion in adipocytes .
12832401	0	syntaxin4	36,45	Tomosyn	0,7	syntaxin4	Tomosyn	6810	134957	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation .
19967551	0	syntaxin_11	6,17	STX11	24,29	syntaxin 11	STX11	8676	8676	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Novel syntaxin_11 gene -LRB- STX11 -RRB- mutation in three Argentinean patients with hemophagocytic_lymphohistiocytosis .
9070225	0	syntaxin_1A	14,25	HPC-1	26,31	syntaxin 1A	HPC-1	20907(Tax:10090)	20907(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|inhibits inhibits|nsubj|END_ENTITY	Overexpressed syntaxin_1A / HPC-1 inhibits insulin secretion via a regulated pathway , but does not influence glucose metabolism and intracellular Ca2 + in insulinoma cell line beta_TC3 cells .
12209004	0	syntaxin_1A	50,61	SNAP-23	42,49	syntaxin 1A	SNAP-23	6804	8773	Gene	Gene	complex|amod|START_ENTITY complex|compound|END_ENTITY	CFTR chloride channels are regulated by a SNAP-23 / syntaxin_1A complex .
9177791	0	syntaxin_1A	27,38	STX1A	45,50	syntaxin 1A	STX1A	6804	6804	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping of the human HPC-1 / syntaxin_1A gene -LRB- STX1A -RRB- to chromosome 7 band q11 .2 .
9763659	0	syntaxin_1A	33,44	STX1A	51,56	syntaxin 1A	STX1A	6804	6804	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hemizygous deletion of the HPC-1 / syntaxin_1A gene -LRB- STX1A -RRB- in patients with Williams_syndrome .
15620717	0	syntaxin_1A	12,23	chromogranins_A_and_B	87,108	syntaxin 1A	chromogranins A and B	6804	1113;1114	Gene	Gene	Presence|nmod|START_ENTITY Presence|nmod|END_ENTITY	Presence of syntaxin_1A in secretory granules of chromaffin cells and interaction with chromogranins_A_and_B .
17032905	0	syntaxin_1A	159,170	norepinephrine_transporter	92,118	syntaxin 1A	norepinephrine transporter	6804	6530	Gene	Gene	complexes|amod|START_ENTITY changes|nmod|complexes linked|nmod|changes expression|acl|linked expression|compound|END_ENTITY	Amphetamine induces a calcium/calmodulin-dependent _ protein_kinase_II-dependent reduction in norepinephrine_transporter surface expression linked to changes in syntaxin_1A / transporter complexes .
17188889	0	syntaxin_1A	76,87	norepinephrine_transporter	44,70	syntaxin 1A	norepinephrine transporter	6804	6530	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Calcium-dependent interactions of the human norepinephrine_transporter with syntaxin_1A .
12175857	0	syntaxin_1A	8,19	serotonin_transporter	23,44	syntaxin 1A	serotonin transporter	6804	6532	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of syntaxin_1A on serotonin_transporter expression in developing thalamocortical neurons .
18277055	0	syntaxin_2	99,109	epimorphin	110,120	syntaxin 2	epimorphin	13852(Tax:10090)	13852(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A new ENU-induced mutant mouse with defective spermatogenesis caused by a nonsense mutation of the syntaxin_2 / epimorphin -LRB- Stx2/Epim -RRB- gene .
25674084	0	syntaxin_3	11,21	IL-6	42,46	syntaxin 3	IL-6	6809	3569	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for syntaxin_3 in the secretion of IL-6 from dendritic cells following activation of toll-like receptors .
10788461	0	syntaxin_3	34,44	Munc18-2	0,8	syntaxin 3	Munc18-2	6809	6813	Gene	Gene	partner|nmod|START_ENTITY END_ENTITY|appos|partner	Munc18-2 , a functional partner of syntaxin_3 , controls apical membrane trafficking in epithelial cells .
9168999	0	syntaxin_4	40,50	Munc18c	54,61	syntaxin 4	Munc18c	6810	6814	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of the binding of SNAP-23 to syntaxin_4 by Munc18c .
11063739	0	syntaxin_4	32,42	Rab4	22,26	syntaxin 4	Rab4	81803(Tax:10116)	25532(Tax:10116)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Direct interaction of Rab4 with syntaxin_4 .
12082176	0	syntaxin_6	60,70	SNAP-25	74,81	syntaxin 6	SNAP-25	10228	6616	Gene	Gene	START_ENTITY|appos|homolog homolog|compound|END_ENTITY	Three-dimensional structure of the amino-terminal domain of syntaxin_6 , a SNAP-25 C homolog .
26680738	0	syntaxin_7	24,34	Munc13-4	0,8	syntaxin 7	Munc13-4	8417	201294	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Munc13-4 interacts with syntaxin_7 , regulates late endosomal maturation , endosomal signaling and TLR9-initiated cellular responses .
15897714	0	syntaxin_binding_protein_1	4,30	Stxbp1	37,43	syntaxin binding protein 1	Stxbp1	20910(Tax:10090)	20910(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The syntaxin_binding_protein_1 gene -LRB- Stxbp1 -RRB- is a candidate for an ethanol preference drinking locus on mouse chromosome 2 .
22938480	0	syntenin	6,14	Mda-9	0,5	syntenin	Mda-9	6386	6386	Gene	Gene	promotes|nsubj|START_ENTITY END_ENTITY|parataxis|promotes	Mda-9 / syntenin promotes human brain_glioma migration through focal adhesion kinase -LRB- FAK -RRB- - JNK and FAK-AKT signaling .
18256285	0	syntenin	62,70	frizzled_7	95,105	syntenin	frizzled 7	447442(Tax:8355)	378787(Tax:8355)	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled_7 and supports noncanonical Wnt signaling .
24235146	0	syntenin	170,178	syndecan-4	159,169	syntenin	syndecan-4	53378(Tax:10090)	20971(Tax:10090)	Gene	Gene	pathways|compound|START_ENTITY pathways|amod|END_ENTITY	Angiopoietin-2 secretion by endothelial cell exosomes : regulation by the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- / Akt/endothelial _ nitric_oxide_synthase -LRB- eNOS -RRB- and syndecan-4 / syntenin pathways .
16034076	0	syntenin-1	43,53	CD6	24,27	syntenin-1	CD6	6386	923	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The lymphocyte receptor CD6 interacts with syntenin-1 , a scaffolding protein containing PDZ domains .
15276154	0	syntenin-1	73,83	glycine_transporter_2	13,34	syntenin-1	glycine transporter 2	83841(Tax:10116)	171148(Tax:10116)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The neuronal glycine_transporter_2 interacts with the PDZ domain protein syntenin-1 .
11152476	0	syntenin-1	64,74	neurofascin	37,48	syntenin-1	neurofascin	6386	23114	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2 , both of which reveal self-associating activity .
14499607	0	syntrophin	10,20	stn-1	4,9	syntrophin	stn-1	181029(Tax:6239)	266844(Tax:6239)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin .
11016747	0	synuclein_gamma	31,46	SNCG	48,52	synuclein gamma	SNCG	6623	6623	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Transcriptional suppression of synuclein_gamma -LRB- SNCG -RRB- expression in human breast_cancer cells by the growth inhibitory cytokine oncostatin_M .
22174421	0	systemic_RNA_interference-defective-1_transmembrane_family_member_1	13,80	SIDT1	82,87	systemic RNA interference-defective-1 transmembrane family member 1	SIDT1	54847	54847	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Homo_sapiens systemic_RNA_interference-defective-1_transmembrane_family_member_1 -LRB- SIDT1 -RRB- protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance .
3147883	0	t-PA	24,28	DHFR	0,4	t-PA	DHFR	281407(Tax:9913)	508809(Tax:9913)	Gene	Gene	coamplification|nmod|START_ENTITY coamplification|amod|END_ENTITY	DHFR coamplification of t-PA in DHFR + bovine endothelial cells : in vitro characterization of the purified serine protease .
3147883	0	t-PA	24,28	DHFR	32,36	t-PA	DHFR	281407(Tax:9913)	508809(Tax:9913)	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	DHFR coamplification of t-PA in DHFR + bovine endothelial cells : in vitro characterization of the purified serine protease .
10453514	0	t-PA	12,16	PAI-1	18,23	t-PA	PAI-1	25692(Tax:10116)	24617(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|expression expression|compound|END_ENTITY	-LSB- Changes in t-PA , PAI-1 gene expression of coronary arteries with preconditioning in acute myocardial_infarction rat -RSB- .
11208392	0	t-PA	24,28	PAI-1	78,83	t-PA	PAI-1	5327	5054	Gene	Gene	activators|dep|START_ENTITY activators|nsubj|activators activators|dobj|inhibitors inhibitors|dep|END_ENTITY	Plasminogen activators -LRB- t-PA and u-PA -RRB- and plasminogen activators inhibitors -LRB- PAI-1 and PAI-2 -RRB- in some myeloproliferative_syndromes .
1623118	0	t-PA	39,43	PAI-1	91,96	t-PA	PAI-1	5327	5054	Gene	Gene	activators|dep|START_ENTITY activators|appos|END_ENTITY	The release of plasminogen activators -LRB- t-PA and u-PA -RRB- and plasminogen activator inhibitor -LRB- PAI-1 -RRB- after venous_stasis .
1796399	0	t-PA	135,139	PAI-1	0,5	t-PA	PAI-1	5327	5054	Gene	Gene	concentration|nmod|START_ENTITY controlling|dobj|concentration plays|advcl|controlling plays|nsubj|END_ENTITY	PAI-1 plays an important role in the expression of t-PA activity in the euglobulin clot lysis by controlling the concentration of free t-PA .
1796399	0	t-PA	51,55	PAI-1	0,5	t-PA	PAI-1	5327	5054	Gene	Gene	activity|amod|START_ENTITY expression|nmod|activity role|nmod|expression plays|iobj|role plays|nsubj|END_ENTITY	PAI-1 plays an important role in the expression of t-PA activity in the euglobulin clot lysis by controlling the concentration of free t-PA .
1907771	0	t-PA	100,104	PAI-1	54,59	t-PA	PAI-1	5327	5054	Gene	Gene	inhibitor-1|appos|START_ENTITY inhibitor-1|appos|END_ENTITY	Molecular forms of plasminogen activator inhibitor-1 -LRB- PAI-1 -RRB- and tissue-type_plasminogen_activator -LRB- t-PA -RRB- in human plasma .
2500878	0	t-PA	86,90	PAI-1	41,46	t-PA	PAI-1	5327	5054	Gene	Gene	Quantification|appos|START_ENTITY Quantification|nmod|inhibitor inhibitor|appos|END_ENTITY	-LSB- Quantification of a specific inhibitor -LRB- PAI-1 -RRB- of tissue-type plasminogen activator -LRB- t-PA -RRB- in the plasma -RSB- .
2503541	0	t-PA	129,133	PAI-1	60,65	t-PA	PAI-1	5327	5054	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY bound|dep|tissue-type_plasminogen_activator plasminogen_activator_inhibitor_type_1|dep|bound plasminogen_activator_inhibitor_type_1|appos|END_ENTITY	Interaction between plasminogen_activator_inhibitor_type_1 -LRB- PAI-1 -RRB- bound to fibrin and either tissue-type_plasminogen_activator -LRB- t-PA -RRB- or urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
2510360	0	t-PA	17,21	PAI-1	60,65	t-PA	PAI-1	5327	5054	Gene	Gene	PAI-1|amod|START_ENTITY levels|nmod|PAI-1 levels|nmod|t-PA t-PA|nmod|END_ENTITY	Plasma levels of t-PA free PAI-1 and a complex of t-PA with PAI-1 in human males and females at various ages .
2510360	0	t-PA	50,54	PAI-1	27,32	t-PA	PAI-1	5327	5054	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Plasma levels of t-PA free PAI-1 and a complex of t-PA with PAI-1 in human males and females at various ages .
3133814	0	t-PA	68,72	PAI-1	105,110	t-PA	PAI-1	5327	5054	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Daytime fluctuations in blood of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and its fast-acting inhibitor -LRB- PAI-1 -RRB- .
7474459	0	t-PA	49,53	PAI-1	94,99	t-PA	PAI-1	5327	5054	Gene	Gene	activator|appos|START_ENTITY Changes|nmod|activator inhibitor|nsubj|Changes inhibitor|dobj|1 1|appos|END_ENTITY	-LSB- Changes in plasma tissue plasminogen activator -LRB- t-PA -RRB- and plasminogen activator inhibitor 1 -LRB- PAI-1 -RRB- by the interferon treatment for chronic hepatitis_C -RSB- .
7740461	0	t-PA	68,72	PAI-1	113,118	t-PA	PAI-1	5327	5054	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	The role of the finger domain of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- in initiation and progression of thrombolysis .
8165591	0	t-PA	72,76	PAI-1	117,122	t-PA	PAI-1	5327	5054	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Effect of isotretinoin on endogenous tissue-type_plasminogen_activator -LRB- t-PA -RRB- and plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- in humans .
8236140	0	t-PA	61,65	PAI-1	34,39	t-PA	PAI-1	25692(Tax:10116)	24617(Tax:10116)	Gene	Gene	variant|nmod|START_ENTITY variant|amod|resistant resistant|amod|END_ENTITY	A slow clearing , fibrin-specific , PAI-1 resistant variant of t-PA -LRB- T103N , KHRR 296-299 AAAA -RRB- .
8569037	0	t-PA	85,89	PAI-1	108,113	t-PA	PAI-1	5327	5054	Gene	Gene	PAI-1|compound|START_ENTITY levels|compound|PAI-1 levels|compound|END_ENTITY	-LSB- Studies on the mechanism of hyperfibrinolysis in liver_cirrhosis -- changes of plasma t-PA , PAI-1 and active PAI-1 levels in liver_cirrhosis -RSB- .
8725727	0	t-PA	49,53	PAI-1	99,104	t-PA	PAI-1	25692(Tax:10116)	24617(Tax:10116)	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Production of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and type-1 plasminogen activator inhibitor -LRB- PAI-1 -RRB- in mildly cirrhotic rat liver .
9184262	0	t-PA	48,52	PAI-1	82,87	t-PA	PAI-1	5327	5054	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Imbalance of tissue-type_plasminogen_activator -LRB- t-PA -RRB- and its specific inhibitor -LRB- PAI-1 -RRB- in patients with rheumatoid_arthritis associated with disease activity .
25702149	0	t-PA	37,41	Receptor-associated_protein	0,27	t-PA	Receptor-associated protein	25692(Tax:10116)	116565(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Receptor-associated_protein promotes t-PA expression , reduces PAI-1 expression and improves neurorecovery after acute ischemic_stroke .
24601228	0	t-PA	0,4	VEGF	16,20	t-PA	VEGF	5327	7422	Gene	Gene	stimulates|amod|START_ENTITY END_ENTITY|nsubj|stimulates	t-PA stimulates VEGF expression in endothelial cells via ERK2/p38 signaling pathways .
11522025	0	t-PA	123,127	t-PA	25,29	t-PA	t-PA	281407(Tax:9913)	281407(Tax:9913)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Synergistic induction of t-PA by vascular_endothelial_growth_factor and basic_fibroblast_growth_factor and localization of t-PA to Weibel-Palade_bodies in bovine microvascular endothelial cells .
11522025	0	t-PA	25,29	t-PA	123,127	t-PA	t-PA	281407(Tax:9913)	281407(Tax:9913)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Synergistic induction of t-PA by vascular_endothelial_growth_factor and basic_fibroblast_growth_factor and localization of t-PA to Weibel-Palade_bodies in bovine microvascular endothelial cells .
11450845	0	t-PA	144,148	tissue-type_plasminogen_activator	109,142	t-PA	tissue-type plasminogen activator	5327	5327	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Linkage disequilibrium and haplotype analysis among eight novel single-nucleotide polymorphisms in the human tissue-type_plasminogen_activator -LRB- t-PA -RRB- gene .
19931890	0	t-PA	46,50	tissue-type_plasminogen_activator	11,44	t-PA	tissue-type plasminogen activator	397121(Tax:9823)	397121(Tax:9823)	Gene	Gene	Release|appos|START_ENTITY Release|nmod|END_ENTITY	Release of tissue-type_plasminogen_activator -LRB- t-PA -RRB- in the splanchnic circulation of the anaesthetised pig during high sympathetic tone .
3937265	0	t-PA	50,54	tissue-type_plasminogen_activator	15,48	t-PA	tissue-type plasminogen activator	5327	5327	Gene	Gene	Assay|appos|START_ENTITY Assay|nmod|END_ENTITY	Assay of human tissue-type_plasminogen_activator -LRB- t-PA -RRB- with an enzyme-linked immunosorbent assay -LRB- ELISA -RRB- based on three murine monoclonal antibodies to t-PA .
9099997	0	t-PA	50,54	tissue-type_plasminogen_activator	15,48	t-PA	tissue-type plasminogen activator	5327	5327	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Enhancement of tissue-type_plasminogen_activator -LRB- t-PA -RRB- activity by purified t-PA receptor expressed in human endothelial cells .
2493685	0	t-PA	29,33	u-PA	23,27	t-PA	u-PA	5327	5328	Gene	Gene	concentrations|compound|START_ENTITY END_ENTITY|appos|concentrations	Placental and decidual u-PA , t-PA , PAI-1 and PAI-2 concentrations , as affected by cervical dilatation with laminaria tents or Hegar dilators .
3132969	0	t-PA	69,73	u-PA	90,94	t-PA	u-PA	5327	5328	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Artificial exon shuffling between tissue-type_plasminogen_activator -LRB- t-PA -RRB- and urokinase -LRB- u-PA -RRB- : a comparative study on the fibrinolytic properties of t-PA/u-PA hybrid proteins .
9674732	0	t-PA	78,82	u-PA	58,62	t-PA	u-PA	5327	5328	Gene	Gene	contrast|nmod|START_ENTITY END_ENTITY|nmod|contrast	Plasminogen activator in acute myeloid leukaemic marrows : u-PA in contrast to t-PA in normal marrow .
3653076	0	t-complex	33,42	TCP1	49,53	t-complex	TCP1	20998(Tax:10090)	21454(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human homologue of the mouse t-complex gene , TCP1 , is located on chromosome 6 but is not near the HLA region .
1773933	0	tM2	53,56	tM3	58,61	tM2	tM3	22003(Tax:10090)	22003(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Characterization of novel partial t-haplotypes tM1 , tM2 , tM3 , tM4 -RSB- .
1773933	0	tM3	58,61	tM2	53,56	tM3	tM2	22003(Tax:10090)	22003(Tax:10090)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Characterization of novel partial t-haplotypes tM1 , tM2 , tM3 , tM4 -RSB- .
16444599	0	tNOX	0,4	COX-2	31,36	tNOX	COX-2	10495	4513	Gene	Gene	START_ENTITY|appos|target target|nmod|END_ENTITY	tNOX , an alternative target to COX-2 to explain the anticancer activities of non-steroidal anti-inflammatory drugs -LRB- NSAIDS -RRB- .
22846226	0	tNOX	123,127	ENOX2	129,134	tNOX	ENOX2	10495	10495	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Chemotherapeutic agents enhance cell migration and epithelial-to-mesenchymal transition through transient up-regulation of tNOX -LRB- ENOX2 -RRB- protein .
21735133	0	tNOX	50,54	tumor-associated_NADH_oxidase	19,48	tNOX	tumor-associated NADH oxidase	10495	10495	Gene	Gene	Down-regulation|appos|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of tumor-associated_NADH_oxidase , tNOX -LRB- ENOX2 -RRB- , enhances capsaicin-induced inhibition of gastric_cancer cell growth .
10390010	0	tPA	55,58	PAI-1	103,108	tPA	PAI-1	5327	5054	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY value|nmod|tissue-type_plasminogen_activator value|appos|END_ENTITY	Prognostic value of tissue-type_plasminogen_activator -LRB- tPA -RRB- and its complex with the type-1 inhibitor -LRB- PAI-1 -RRB- in breast_cancer .
17689411	0	tPA	78,81	PAI-1	15,20	tPA	PAI-1	5327	5054	Gene	Gene	levels|compound|START_ENTITY polymorphism|nmod|levels G/A|dobj|polymorphism G/A|nsubj|Association Association|nmod|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphism and changes in PAI-1 / tPA levels in stroke : a case-control study .
17689411	0	tPA	78,81	PAI-1	72,77	tPA	PAI-1	5327	5054	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphism and changes in PAI-1 / tPA levels in stroke : a case-control study .
24922319	0	tPA	53,56	PAI-1	14,19	tPA	PAI-1	5327	5054	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of PAI-1 antiproteolytic activity against tPA by RNA aptamers .
26491796	0	tPA	13,16	PAI-1	30,35	tPA	PAI-1	5327	5054	Gene	Gene	release|compound|START_ENTITY release|appos|degradation degradation|amod|END_ENTITY	Overwhelming tPA release , not PAI-1 degradation , is responsible for hyperfibrinolysis in severely injured trauma patients .
9461198	0	tPA	30,33	Tissue_plasminogen_activator	0,28	tPA	Tissue plasminogen activator	18791(Tax:10090)	18791(Tax:10090)	Gene	Gene	increases|appos|START_ENTITY increases|amod|END_ENTITY	Tissue_plasminogen_activator -LRB- tPA -RRB- increases neuronal_damage after focal cerebral_ischemia in wild-type and tPA-deficient mice .
20845058	0	tPA	32,35	albumin	44,51	tPA	albumin	5327	213	Gene	Gene	IL-6|appos|START_ENTITY END_ENTITY|nsubj|IL-6	Gingival crevicular fluid IL-6 , tPA , PAI-2 , albumin levels following initial periodontal treatment in chronic_periodontitis patients with or without type 2 diabetes .
12408467	0	tPA	62,65	tissue-type_plasminogen_activator	27,60	tPA	tissue-type plasminogen activator	5327	5327	Gene	Gene	content|appos|START_ENTITY content|amod|END_ENTITY	Prognostic significance of tissue-type_plasminogen_activator -LRB- tPA -RRB- content in gastric_cancer and surrounding mucosa .
21519332	0	tPA	80,83	tissue-type_plasminogen_activator	45,78	tPA	tissue-type plasminogen activator	18791(Tax:10090)	18791(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Compartment - and context-specific changes in tissue-type_plasminogen_activator -LRB- tPA -RRB- activity following brain_injury and pharmacological stimulation .
3137452	0	tPA	63,66	tissue-type_plasminogen_activator	28,61	tPA	tissue-type plasminogen activator	25692(Tax:10116)	25692(Tax:10116)	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	Dexamethasone inhibition of tissue-type_plasminogen_activator -LRB- tPA -RRB- activity : paradoxical induction of both tPA antigen and plasminogen activator inhibitor .
14529669	0	tPA	72,75	tissue_plasminogen_activator	42,70	tPA	tissue plasminogen activator	100128998	100128998	Gene	Gene	concentration|appos|START_ENTITY concentration|nmod|END_ENTITY	High preoperative plasma concentration of tissue_plasminogen_activator -LRB- tPA -RRB- is an independent marker for shorter overall survival in patients with ovarian_cancer .
14690546	0	tPA	45,48	tissue_plasminogen_activator	15,43	tPA	tissue plasminogen activator	100128998	100128998	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	High levels of tissue_plasminogen_activator -LRB- tPA -RRB- antigen precede the development of type 2 diabetes in a longitudinal population study .
23906635	0	tPA	70,73	tissue_plasminogen_activator	40,68	tPA	tissue plasminogen activator	18791(Tax:10090)	18791(Tax:10090)	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Dopamine_D3_receptor deletion increases tissue_plasminogen_activator -LRB- tPA -RRB- activity in prefrontal cortex and hippocampus .
24152103	0	tPA	50,53	tissue_plasminogen_activator	20,48	tPA	tissue plasminogen activator	100128998	100128998	Gene	Gene	Production|appos|START_ENTITY Production|nmod|END_ENTITY	Production of human tissue_plasminogen_activator -LRB- tPA -RRB- in Cucumis_sativus .
12819782	0	tRNA_synthetase_cofactor_p38	52,80	FUSE-binding_protein	18,38	tRNA synthetase cofactor p38	FUSE-binding protein	26416(Tax:10090)	51886(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of FUSE-binding_protein and c-myc by tRNA_synthetase_cofactor_p38 is required for lung cell differentiation .
16914140	0	tTG	54,57	VEGF	186,190	tTG	VEGF	7052	7422	Gene	Gene	II|appos|START_ENTITY formation|nmod|II formation|dep|mechanism mechanism|nmod|END_ENTITY	Complex formation between tissue_transglutaminase II -LRB- tTG -RRB- and vascular_endothelial_growth_factor_receptor_2 -LRB- VEGFR-2 -RRB- : proposed mechanism for modulation of endothelial cell response to VEGF .
16914140	0	tTG	54,57	VEGFR-2	110,117	tTG	VEGFR-2	7052	3791	Gene	Gene	II|appos|START_ENTITY II|appos|END_ENTITY	Complex formation between tissue_transglutaminase II -LRB- tTG -RRB- and vascular_endothelial_growth_factor_receptor_2 -LRB- VEGFR-2 -RRB- : proposed mechanism for modulation of endothelial cell response to VEGF .
16696340	0	tTG	46,49	tissue_transglutaminase	21,44	tTG	tissue transglutaminase	281528(Tax:9913)	281528(Tax:9913)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of tissue_transglutaminase -LRB- tTG -RRB- antisense oligodeoxynucleotides on tTG expression in cultured bovine trabecular meshwork cells .
16696340	0	tTG	46,49	tissue_transglutaminase	21,44	tTG	tissue transglutaminase	281528(Tax:9913)	281528(Tax:9913)	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	Inhibitory effect of tissue_transglutaminase -LRB- tTG -RRB- antisense oligodeoxynucleotides on tTG expression in cultured bovine trabecular meshwork cells .
19654435	0	tTG	41,44	tissue_transglutaminase	16,39	tTG	tissue transglutaminase	21817(Tax:10090)	21817(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of tissue_transglutaminase -LRB- tTG -RRB- in kidney of ICR-derived_glomerulonephritis -LRB- ICGN -RRB- mice .
2164120	0	tac_antigen	143,154	interleukin-2	23,36	tac antigen	interleukin-2	3559	3558	Gene	Gene	express|dobj|START_ENTITY phenotype|acl:relcl|express dependent|nmod|phenotype END_ENTITY|amod|dependent	Characterization of an interleukin-2 dependent human leukemic cell line , PER-315 , with an immature T cell phenotype which does not express the tac_antigen .
2825998	0	tac_antigen	46,57	interleukin-2	14,27	tac antigen	interleukin-2	3559	3558	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of interleukin-2 and expression of tac_antigen in Hodgkin_disease .
20660792	0	tachykinin_4	25,37	TAC4	44,48	tachykinin 4	TAC4	93670(Tax:10090)	93670(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Targeted deletion of the tachykinin_4 gene -LRB- TAC4 - / - -RRB- influences the early stages of B lymphocyte development .
24817687	0	tachykinin_receptor_1	27,48	TACR1	49,54	tachykinin receptor 1	TACR1	6869	6869	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Genetic association of the tachykinin_receptor_1 TACR1 gene in bipolar_disorder , attention deficit_hyperactivity_disorder , and the alcohol_dependence_syndrome .
9628820	0	tailless	38,46	TLX	53,56	tailless	TLX	43656(Tax:7227)	4179	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human homologue of the Drosophila tailless gene -LRB- TLX -RRB- : characterization and mapping to a region of common deletion in human lymphoid_leukemia on chromosome 6q21 .
20133786	0	takeout	26,33	Pdp1epsilon	50,61	takeout	Pdp1epsilon	43036(Tax:7227)	45588(Tax:7227)	Gene	Gene	regulated|nsubjpass|START_ENTITY regulated|nmod|END_ENTITY	The circadian output gene takeout is regulated by Pdp1epsilon .
12816868	0	tal-1	43,48	NF-kappaB	0,9	tal-1	NF-kappaB	21349(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappaB activation in premalignant mouse tal-1 / scl thymocytes and tumors .
26386044	0	talpid3	40,47	KIAA0586	54,62	talpid3	KIAA0586	423540(Tax:9031)	423540(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in human homologue of chicken talpid3 gene -LRB- KIAA0586 -RRB- cause a hybrid ciliopathy with overlapping features of Jeune and Joubert_syndromes .
7531049	0	tamm-horsfall_protein	18,39	THP	41,44	tamm-horsfall protein	THP	281567(Tax:9913)	281567(Tax:9913)	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Bovine and rodent tamm-horsfall_protein -LRB- THP -RRB- genes : cloning , structural analysis , and promoter identification .
10853965	0	tartrate-resistant_acid_phosphatase	25,60	Acp_5	62,67	tartrate-resistant acid phosphatase	Acp 5	11433(Tax:10090)	11433(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Widespread expression of tartrate-resistant_acid_phosphatase -LRB- Acp_5 -RRB- in the mouse embryo .
19801646	0	tartrate-resistant_acid_phosphatase	22,57	TRAP	59,63	tartrate-resistant acid phosphatase	TRAP	11433(Tax:10090)	11433(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
19801646	0	tartrate-resistant_acid_phosphatase	22,57	interleukin_4	79,92	tartrate-resistant acid phosphatase	interleukin 4	11433(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Complex regulation of tartrate-resistant_acid_phosphatase -LRB- TRAP -RRB- expression by interleukin_4 -LRB- IL-4 -RRB- : IL-4 indirectly suppresses receptor activator of NF-kappaB ligand -LRB- RANKL -RRB- - mediated TRAP expression but modestly induces its expression directly .
12767454	0	task_2	60,66	P300	16,20	task 2	P300	8645	2033	Gene	Gene	activity|nmod|START_ENTITY activity|nummod|END_ENTITY	An MEG study of P300 activity during a color discrimination task_2 : source localization study .
16537915	0	taspase_1	35,44	TFIIA	10,15	taspase 1	TFIIA	734301(Tax:8355)	398704(Tax:8355)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Uncleaved TFIIA is a substrate for taspase_1 and active in transcription .
21556531	0	tata-binding_protein	42,62	oncoprotein_mdm2	6,22	tata-binding protein	oncoprotein mdm2	6908	4193	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human oncoprotein_mdm2 interacts with the tata-binding_protein in-vitro and in-vivo .
8468346	0	tau	8,11	tau	80,83	tau	tau	4137	4137	Gene	Gene	START_ENTITY|nmod|cells cells|acl|expressing expressing|dobj|END_ENTITY	A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau .
12408968	0	tauCstF-64	76,86	CstF-64	44,51	tauCstF-64	CstF-64	23283	1478	Gene	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The gene CSTF2T , encoding the human_variant CstF-64 polyadenylation protein tauCstF-64 , lacks introns and may be associated with male sterility .
8774855	0	taurine_transporter	32,51	TAUT	53,57	taurine transporter	TAUT	21366(Tax:10090)	21366(Tax:10090)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the mouse retinal taurine_transporter -LRB- TAUT -RRB- by protein kinases in Xenopus oocytes .
23180277	0	taurine_transporter	14,33	TauT	35,39	taurine transporter	TauT	6533	6533	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of taurine_transporter -LRB- TauT -RRB- is modulated by heat_shock_factor_1 -LRB- HSF1 -RRB- in motor neurons of ALS .
15142033	0	taurine_transporter	14,33	TonEBP	94,100	taurine transporter	TonEBP	6533	10725	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of taurine_transporter is regulated through the TonE -LRB- tonicity-responsive element -RRB- / TonEBP -LRB- TonE-binding_protein -RRB- pathway and contributes to cytoprotection in HepG2 cells .
11097423	0	tax	80,83	CBP	46,49	tax	CBP	6900	1387	Gene	Gene	function|nmod|START_ENTITY function|nmod|END_ENTITY	Insight into the tumor suppressor function of CBP through the viral oncoprotein tax .
15239133	0	tax	147,150	CCL5	99,103	tax	CCL5	1491938(Tax:11908)	6352	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Elevated expression of CCL5/RANTES in adult_T-cell_leukemia cells : possible transactivation of the CCL5 gene by human_T-cell_leukemia_virus_type_I tax .
10666215	0	tax	9,12	CD4	35,38	tax	CD4	1491938(Tax:11908)	920	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|nummod|END_ENTITY	Abundant tax protein expression in CD4 + T cells infected with human_T-cell_lymphotropic_virus_type_I _ -LRB- HTLV-I -RRB- is prevented by cytotoxic T lymphocytes .
10336413	0	tax	71,74	IKKgamma	0,8	tax	IKKgamma	1491938(Tax:11908)	8517	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T_cell_leukemia_virus_type_1 .
24416335	0	tax	16,19	IL-15	0,5	tax	IL-15	21367(Tax:10090)	16168(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY mice|compound|END_ENTITY	IL-15 deficient tax mice reveal a role for IL-1a in tumor immunity .
8670878	0	tax	47,50	IL-2	18,22	tax	IL-2	1491938(Tax:11908)	3558	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element .
8628274	0	tax	35,38	IkappaBbeta	16,27	tax	IkappaBbeta	1491938(Tax:11908)	4793	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|nmod|protein	Inactivation of IkappaBbeta by the tax protein of human_T-cell_leukemia_virus_type_1 : a potential mechanism for constitutive induction of NF-kappaB .
10572100	0	tax	40,43	NF-kappaB	65,74	tax	NF-kappaB	1491938(Tax:11908)	4790	Gene	Gene	cascade|nmod|START_ENTITY cascade|nmod|induction induction|nmod|translocation translocation|amod|END_ENTITY	Inhibition of caspase cascade by HTLV-I tax through induction of NF-kappaB nuclear translocation .
14963024	0	tax	39,42	NF-kappaB	76,85	tax	NF-kappaB	6900	4790	Gene	Gene	induction|compound|START_ENTITY induction|nmod|END_ENTITY	Human_T-cell_lymphotropic_virus_type_1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65 .
16287853	0	tax	136,139	NF-kappaB	80,89	tax	NF-kappaB	6900	4790	Gene	Gene	oncoprotein|compound|START_ENTITY mediate|nmod|oncoprotein mediate|dobj|activation activation|amod|END_ENTITY	Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell_leukemia_virus tax oncoprotein .
8628274	0	tax	35,38	NF-kappaB	138,147	tax	NF-kappaB	1491938(Tax:11908)	4790	Gene	Gene	protein|compound|START_ENTITY IkappaBbeta|nmod|protein Inactivation|nmod|IkappaBbeta Inactivation|dep|mechanism mechanism|nmod|induction induction|nmod|END_ENTITY	Inactivation of IkappaBbeta by the tax protein of human_T-cell_leukemia_virus_type_1 : a potential mechanism for constitutive induction of NF-kappaB .
18375384	0	tax	47,50	ZNF268	61,67	tax	ZNF268	6900	10795	Gene	Gene	represses|nsubj|START_ENTITY represses|dobj|expression expression|compound|END_ENTITY	Human_T-cell_leukemia_virus_type_1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive_element-binding_protein / activating transcription factor pathway .
12805427	0	tax	151,154	p21	0,3	Tax	p21	25356(Tax:10116)	1026	Gene	Gene	type|dep|START_ENTITY transformed|nmod|type cells|acl|transformed prevents|nmod|cells prevents|nsubj|END_ENTITY	p21 -LRB- Waf1/Cip1/Sdi1 -RRB- prevents apoptosis as well as stimulates growth in cells transformed or immortalized by human T-cell_leukemia virus type 1-encoded tax .
15729715	0	tax	107,110	survivin	30,38	tax	survivin	1491938(Tax:11908)	11799(Tax:10090)	Gene	Gene	pathway|nmod|START_ENTITY activation|nmod|pathway activation|nmod|END_ENTITY	Transcriptional activation of survivin through the NF-kappaB pathway by human_T-cell_leukemia_virus_type_I tax .
10567539	0	tax	20,23	tax	39,42	tax	tax	6900	6900	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner .
10567539	0	tax	39,42	tax	20,23	tax	tax	6900	6900	Gene	Gene	transactivation|compound|START_ENTITY transactivation|compound|END_ENTITY	PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner .
8427983	0	tax	143,146	tax	159,162	tax	tax	1491938(Tax:11908)	1491938(Tax:11908)	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human_T-cell_leukemia_virus_type_I _ -LRB- HTLV-I -RRB- tax and HTLV-II tax proteins .
8427983	0	tax	159,162	tax	143,146	tax	tax	1491938(Tax:11908)	1491938(Tax:11908)	Gene	Gene	proteins|compound|START_ENTITY proteins|compound|END_ENTITY	Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human_T-cell_leukemia_virus_type_I _ -LRB- HTLV-I -RRB- tax and HTLV-II tax proteins .
12874278	0	tax-interacting_protein-1	16,41	beta-catenin	51,63	tax-interacting protein-1	beta-catenin	30851	1499	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|activity activity|amod|END_ENTITY	The PDZ protein tax-interacting_protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal_cancer cells .
2101630	0	tax1	97,101	NF-kappa_B	21,31	tax1	NF-kappa B	6900	4790	Gene	Gene	protein|amod|START_ENTITY DNA|nmod|protein DNA|nsubj|Induction Induction|nmod|END_ENTITY	Induction of nuclear NF-kappa_B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein .
19806788	0	tazarotene-induced_gene_1	42,67	TIG1	36,40	tazarotene-induced gene 1	TIG1	5918	5918	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Expression and mutation analysis of TIG1 -LRB- tazarotene-induced_gene_1 -RRB- in human gastric_cancer .
9245618	0	tbpA	36,40	transferrin	117,128	tbpA	transferrin	7276	7018	Gene	Gene	gene|compound|START_ENTITY analysis|nmod|gene analysis|dep|topology topology|nmod|receptors receptors|nmod|acquisition acquisition|amod|END_ENTITY	Sequence analysis of the structural tbpA gene : protein topology and variable regions within neisserial receptors for transferrin iron acquisition .
18347092	0	tbx2b	25,30	Foxn4	0,5	tbx2b	Foxn4	30253(Tax:7955)	30315(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Foxn4 directly regulates tbx2b expression and atrioventricular_canal_formation .
16501170	0	tbx5	25,29	sall4	0,5	tbx5	sall4	30071(Tax:7955)	572527(Tax:7955)	Gene	Gene	downstream|nmod|START_ENTITY acts|dobj|downstream acts|nsubj|END_ENTITY	sall4 acts downstream of tbx5 and is required for pectoral fin outgrowth .
9828136	0	telencephalin	23,36	ICAM-5	15,21	telencephalin	ICAM-5	7087	7087	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Mapping of the ICAM-5 -LRB- telencephalin -RRB- gene , a neuronal member of the ICAM family , to a location between ICAM-1 and ICAM-3 on human chromosome 19p13 .2 .
23019340	0	telencephalin	130,143	Vitronectin	0,11	telencephalin	Vitronectin	7087	7448	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin .
8995416	0	telencephalin	55,68	lymphocyte_function-associated_antigen-1	106,146	telencephalin	lymphocyte function-associated antigen-1	7087	3683	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte_function-associated_antigen-1 .
18849585	0	telethonin	54,64	Siva	21,25	telethonin	Siva	8557	10572	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection .
11964068	0	telokin	43,50	kinase-related_protein	19,41	telokin	kinase-related protein	4638	4638	Gene	Gene	Phosphorylation|appos|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation of kinase-related_protein -LRB- telokin -RRB- in tonic and phasic smooth muscles .
9288757	0	telomerase_catalytic_subunit	26,54	hEST2	0,5	telomerase catalytic subunit	hEST2	7015	7015	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|appos|gene	hEST2 , the putative human telomerase_catalytic_subunit gene , is up-regulated in tumor cells and during immortalization .
11497281	0	telomerase_catalytic_subunit	34,62	hTERT	64,69	telomerase catalytic subunit	hTERT	7015	7015	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	FADD gene therapy using the human telomerase_catalytic_subunit -LRB- hTERT -RRB- gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo .
12209957	0	telomerase_catalytic_subunit	30,58	hTERT	60,65	telomerase catalytic subunit	hTERT	7015	7015	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hypermethylation of the human telomerase_catalytic_subunit -LRB- hTERT -RRB- gene correlates with telomerase activity .
15322345	0	telomerase_catalytic_subunit	22,50	hTERT	52,57	telomerase catalytic subunit	hTERT	7015	7015	Gene	Gene	Activity|nmod|START_ENTITY Activity|dep|END_ENTITY	Activity of the human telomerase_catalytic_subunit -LRB- hTERT -RRB- gene promoter could be increased by the SV40 enhancer .
24361335	0	telomerase_reverse_transcriptase	57,89	58-kda_microspherule_protein	4,32	telomerase reverse transcriptase	58-kda microspherule protein	7015	10445	Gene	Gene	expression|amod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The 58-kda_microspherule_protein -LRB- MSP58 -RRB- represses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene expression and cell proliferation by interacting with telomerase_transcriptional_element-interacting_factor -LRB- TEIF -RRB- .
19184104	0	telomerase_reverse_transcriptase	28,60	Alpha-fetoprotein	0,17	telomerase reverse transcriptase	Alpha-fetoprotein	7015	174	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Alpha-fetoprotein and human telomerase_reverse_transcriptase mRNA levels in peripheral blood of patients with hepatocellular_carcinoma .
12646176	0	telomerase_reverse_transcriptase	20,52	BRCA1	72,77	telomerase reverse transcriptase	BRCA1	7015	672	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of human telomerase_reverse_transcriptase gene expression by BRCA1 in human ovarian_cancer cells .
20938050	0	telomerase_reverse_transcriptase	37,69	Grainyhead-like_2	0,17	telomerase reverse transcriptase	Grainyhead-like 2	7015	79977	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Grainyhead-like_2 enhances the human telomerase_reverse_transcriptase gene expression by inhibiting DNA methylation at the 5 ' - CpG island in normal human keratinocytes .
18158869	0	telomerase_reverse_transcriptase	67,99	HBXIP	35,40	telomerase reverse transcriptase	HBXIP	7015	10542	Gene	Gene	upregulation|nmod|START_ENTITY END_ENTITY|nmod|upregulation	Promotion of cell proliferation by HBXIP via upregulation of human telomerase_reverse_transcriptase in human mesenchymal stem cells .
20723213	0	telomerase_reverse_transcriptase	99,131	Leptin	0,6	telomerase reverse transcriptase	Leptin	7015	3952	Gene	Gene	modulation|nmod|START_ENTITY END_ENTITY|nmod|modulation	Leptin as a critical regulator of hepatocellular_carcinoma development through modulation of human telomerase_reverse_transcriptase .
16061629	0	telomerase_reverse_transcriptase	75,107	Signal_transducer_and_activator_of_transcription_3	0,50	telomerase reverse transcriptase	Signal transducer and activator of transcription 3	7015	6774	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- regulates human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in human cancer and primary cells .
11468156	0	telomerase_reverse_transcriptase	22,54	TERT	56,60	telomerase reverse transcriptase	TERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transfer of the human telomerase_reverse_transcriptase -LRB- TERT -RRB- gene into T lymphocytes results in extension of replicative potential .
11859209	0	telomerase_reverse_transcriptase	14,46	TERT	48,52	telomerase reverse transcriptase	TERT	7015	7015	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of telomerase_reverse_transcriptase -LRB- TERT -RRB- in malignant mesotheliomas .
12808208	0	telomerase_reverse_transcriptase	32,64	TERT	66,70	telomerase reverse transcriptase	TERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning of the feline telomerase_reverse_transcriptase -LRB- TERT -RRB- gene and its expression in cell lines and normal tissues .
16026073	0	telomerase_reverse_transcriptase	33,65	TERT	67,71	telomerase reverse transcriptase	TERT	7015	7015	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Immunohistochemical detection of telomerase_reverse_transcriptase -LRB- TERT -RRB- protein in benign and malignant_tumor cells of the breast .
18042045	0	telomerase_reverse_transcriptase	23,55	TERT	57,61	telomerase reverse transcriptase	TERT	7015	7015	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Brm transactivates the telomerase_reverse_transcriptase -LRB- TERT -RRB- gene and modulates the splicing patterns of its transcripts in concert with p54 -LRB- nrb -RRB- .
20460502	0	telomerase_reverse_transcriptase	20,52	TERT	54,58	telomerase reverse transcriptase	TERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Deregulation of the telomerase_reverse_transcriptase -LRB- TERT -RRB- gene by chromosomal translocations in B-cell malignancies .
20964812	0	telomerase_reverse_transcriptase	58,90	TERT	92,96	telomerase reverse transcriptase	TERT	420972(Tax:9031)	420972(Tax:9031)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Alternative splicing and nonsense-mediated_decay regulate telomerase_reverse_transcriptase -LRB- TERT -RRB- expression during virus-induced lymphomagenesis in vivo .
18422743	0	telomerase_reverse_transcriptase	74,106	Tax	43,46	telomerase reverse transcriptase	Tax	7015	1491938(Tax:11908)	Gene	Gene	gene|amod|START_ENTITY Role|nmod|gene Role|nmod|END_ENTITY	Role of human_T-cell_leukemia_virus_type_I Tax in expression of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in human T-cells .
16785237	0	telomerase_reverse_transcriptase	49,81	Transforming_growth_factor_beta	0,31	telomerase reverse transcriptase	Transforming growth factor beta	7015	7040	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|nsubj|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
22894902	0	telomerase_reverse_transcriptase	6,38	b-catenin	67,76	telomerase reverse transcriptase	b-catenin	7015	1499	Gene	Gene	gene|nsubj|START_ENTITY gene|nmod|END_ENTITY	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- is a target gene of b-catenin in human colorectal_tumors .
12479216	0	telomerase_reverse_transcriptase	61,93	c-MYC	45,50	telomerase reverse transcriptase	c-MYC	7015	4609	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|amod|END_ENTITY	The cationic porphyrin_TMPyP4 down-regulates c-MYC and human telomerase_reverse_transcriptase expression and inhibits tumor growth in vivo .
15645079	0	telomerase_reverse_transcriptase	31,63	c-myc	67,72	telomerase reverse transcriptase	c-myc	7015	4609	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcript regulation of human telomerase_reverse_transcriptase by c-myc and mad1 .
10220433	0	telomerase_reverse_transcriptase	41,73	hTERT	75,80	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive and regulated expression of telomerase_reverse_transcriptase -LRB- hTERT -RRB- in human lymphocytes .
10626795	0	telomerase_reverse_transcriptase	61,93	hTERT	95,100	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA methylation analysis of the promoter region of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene .
10861477	0	telomerase_reverse_transcriptase	28,60	hTERT	62,67	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Quantitative measurement of telomerase_reverse_transcriptase -LRB- hTERT -RRB- mRNA in urothelial_cell_carcinomas .
11290757	0	telomerase_reverse_transcriptase	88,120	hTERT	122,127	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Cutting edge : telomerase activation in human T lymphocytes does not require increase in telomerase_reverse_transcriptase -LRB- hTERT -RRB- protein but is associated with hTERT phosphorylation and nuclear translocation .
11855854	0	telomerase_reverse_transcriptase	65,97	hTERT	99,104	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The histone deacetylase inhibitor trichostatin_A derepresses the telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in human cells .
12032853	0	telomerase_reverse_transcriptase	26,58	hTERT	60,65	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Tamoxifen regulates human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene expression differently in breast and endometrial_cancer cells .
12566315	0	telomerase_reverse_transcriptase	46,78	hTERT	80,85	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A chromosome 3-encoded repressor of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene controls the state of hTERT chromatin .
12802289	0	telomerase_reverse_transcriptase	90,122	hTERT	124,129	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Integrations of the hepatitis_B virus -LRB- HBV -RRB- and human_papillomavirus _ -LRB- HPV -RRB- into the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in liver_and_cervical_cancers .
15026805	0	telomerase_reverse_transcriptase	27,59	hTERT	61,66	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of telomerase_reverse_transcriptase -LRB- hTERT -RRB- in lung_tumours .
15142451	0	telomerase_reverse_transcriptase	32,64	hTERT	66,71	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	-LSB- Inhibition of anti-sense human telomerase_reverse_transcriptase -LRB- hTERT -RRB- retroviral vector on lung_cancer cells -RSB- .
16061629	0	telomerase_reverse_transcriptase	75,107	hTERT	109,114	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Signal_transducer_and_activator_of_transcription_3 -LRB- STAT3 -RRB- regulates human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in human cancer and primary cells .
16708388	0	telomerase_reverse_transcriptase	40,72	hTERT	74,79	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Enhanced antitumor effect against human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by vaccination with chemotactic-hTERT gene-modified tumor cell and the combination with anti-4-1BB monoclonal antibodies .
16785237	0	telomerase_reverse_transcriptase	49,81	hTERT	83,88	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	suppresses|dobj|START_ENTITY suppresses|dep|END_ENTITY	Transforming_growth_factor_beta suppresses human telomerase_reverse_transcriptase -LRB- hTERT -RRB- by Smad3 interactions with c-Myc and the hTERT gene .
16798059	0	telomerase_reverse_transcriptase	20,52	hTERT	54,59	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- protein is significantly associated with the progression , recurrence and prognosis of oral_squamous_cell_carcinoma in Taiwan .
17204238	0	telomerase_reverse_transcriptase	101,133	hTERT	135,140	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Human normal T lymphocytes and lymphoid cell lines do express alternative splicing variants of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- mRNA .
17429837	0	telomerase_reverse_transcriptase	33,65	hTERT	67,72	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Loss of heterozygosity and human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in bronchial mucosa of heavy smokers .
18154939	0	telomerase_reverse_transcriptase	19,51	hTERT	53,58	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Detection of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in tissue and pancreatic juice from pancreatic_cancer .
18161862	0	telomerase_reverse_transcriptase	129,161	hTERT	163,168	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Mixed ductal-endocrine_carcinoma derived from intraductal_papillary_mucinous_neoplasm -LRB- IPMN -RRB- of the pancreas identified by human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression .
18197256	0	telomerase_reverse_transcriptase	91,123	hTERT	125,130	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lysine-specific_demethylase_1 -LRB- LSD1 -RRB- Is required for the transcriptional repression of the telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene .
18204433	0	telomerase_reverse_transcriptase	50,82	hTERT	84,89	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Distribution and prognostic significance of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in giant-cell_tumor_of_bone .
18422743	0	telomerase_reverse_transcriptase	74,106	hTERT	108,113	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Role of human_T-cell_leukemia_virus_type_I Tax in expression of the human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene in human T-cells .
19301721	0	telomerase_reverse_transcriptase	6,38	hTERT	40,45	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	START_ENTITY|dobj|expression expression|amod|END_ENTITY	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in borderline_ovarian_tumors : an immunohistochemical study .
19843528	0	telomerase_reverse_transcriptase	47,79	hTERT	30,35	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	activation|appos|START_ENTITY activation|nmod|END_ENTITY	Transcriptional activation of hTERT , the human telomerase_reverse_transcriptase , by nuclear factor of activated T cells .
20052289	0	telomerase_reverse_transcriptase	100,132	hTERT	134,139	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Interferon-inducible IFI16 , a negative regulator of cell growth , down-regulates expression of human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene .
20814747	0	telomerase_reverse_transcriptase	90,122	hTERT	124,129	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	p21 WAF1 is involved in interferon-b-induced attenuation of telomerase activity and human telomerase_reverse_transcriptase -LRB- hTERT -RRB- expression in ovarian_cancer .
26487723	0	telomerase_reverse_transcriptase	6,38	hTERT	40,45	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	transcription|amod|START_ENTITY transcription|compound|END_ENTITY	Human telomerase_reverse_transcriptase -LRB- hTERT -RRB- transcription requires Sp1/Sp3 binding to the promoter and a permissive chromatin environment .
27016301	0	telomerase_reverse_transcriptase	23,55	hTERT	57,62	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	Polymorphisms|nmod|START_ENTITY END_ENTITY|nsubj|Polymorphisms	Polymorphisms in human telomerase_reverse_transcriptase -LRB- hTERT -RRB- gene and susceptibility to gastric_cancer in a Turkish population : Hospital-based case-control study .
9751630	0	telomerase_reverse_transcriptase	63,95	hTERT	97,102	telomerase reverse transcriptase	hTERT	7015	7015	Gene	Gene	transcription|compound|START_ENTITY transcription|compound|END_ENTITY	Telomerase activity in human development is regulated by human telomerase_reverse_transcriptase -LRB- hTERT -RRB- transcription and by alternate splicing of hTERT transcripts .
26481359	0	telomerase_reverse_transcriptase	6,38	hTR	64,67	telomerase reverse transcriptase	hTR	7015	7012	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	Human telomerase_reverse_transcriptase binds to a pre-organized hTR in vivo exposing its template .
15586405	0	telomere_repeat_binding_factor_1	15,47	TRF1	49,53	telomere repeat binding factor 1	TRF1	7013	7013	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	-LSB- Expression of telomere_repeat_binding_factor_1 -LRB- TRF1 -RRB- protein in kidney_cancer -RSB- .
12881513	0	telopeptide_lysyl_hydroxylase	27,56	PLOD2	18,23	telopeptide lysyl hydroxylase	PLOD2	5352	5352	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of PLOD2 as telopeptide_lysyl_hydroxylase , an important enzyme in fibrosis .
25824049	0	ten-eleven_translocation_1	70,96	TET1	98,102	ten-eleven translocation 1	TET1	80312	80312	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	MiR-520b suppresses proliferation of hepatoma cells through targeting ten-eleven_translocation_1 -LRB- TET1 -RRB- mRNA .
19564637	0	ten-eleven_translocation_2	16,42	TET2	44,48	ten-eleven translocation 2	TET2	54790	54790	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the ten-eleven_translocation_2 -LRB- TET2 -RRB- gene in familial_myeloproliferative_neoplasms .
10341219	0	ten-m	68,73	Teneurin-1	0,10	ten-m	Teneurin-1	40464(Tax:7227)	10178	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	Teneurin-1 , a vertebrate homologue of the Drosophila pair-rule gene ten-m , is a neuronal protein with a novel type of heparin-binding domain .
7530615	0	tenascin	18,26	HXB	33,36	tenascin	HXB	102160657	397460(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the tenascin gene -LRB- HXB -RRB- to swine chromosome 1q21 .1 -- > q21 .3 by fluorescence in situ hybridization .
16374482	0	tenascin-C	16,26	IL-13	41,46	tenascin-C	IL-13	3371	3596	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein_kinase_C signaling pathways .
9215732	0	tenascin-C	11,21	NCAM	58,62	tenascin-C	NCAM	3371	4684	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of tenascin-C in cultured hippocampal astrocytes : NCAM and fibronectin immunoreactivity changes .
23043956	0	tenascin-C	17,27	TN-C	29,33	tenascin-C	TN-C	3371	3371	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Postmortem serum tenascin-C -LRB- TN-C -RRB- concentrations in forensic autopsy cases : A pilot study .
16091738	0	tenascin-C	41,51	beta-Catenin	0,12	tenascin-C	beta-Catenin	3371	1499	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	beta-Catenin regulates the expression of tenascin-C in human colorectal_tumors .
10980128	0	tenascin-C	59,69	elastin	121,128	tenascin-C	elastin	116640(Tax:10116)	25043(Tax:10116)	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Inhibition of matrix metalloproteinase activity attenuates tenascin-C production and calcification of implanted purified elastin in rats .
15081471	0	tenascin-C	45,55	elastin	59,66	tenascin-C	elastin	116640(Tax:10116)	25043(Tax:10116)	Gene	Gene	START_ENTITY|nmod|calcification calcification|compound|END_ENTITY	Involvement of matrix metalloproteinases and tenascin-C in elastin calcification .
18061975	0	tenascin-C	14,24	tumor_necrosis_factor-alpha	39,66	tenascin-C	tumor necrosis factor-alpha	3371	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of tenascin-C expression by tumor_necrosis_factor-alpha in cultured human osteoarthritis chondrocytes .
19690384	0	tenascin_C	84,94	PDGFR	95,100	tenascin C	PDGFR	21923(Tax:10090)	18596(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin_C / PDGFR pathway .
18632986	0	teneurin	23,31	ina-1	142,147	teneurin	ina-1	175953(Tax:6239)	176296(Tax:6239)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|END_ENTITY	Caenorhabditis_elegans teneurin , ten-1 , is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1 .
21651764	0	teneurin-1	6,16	EMX2	73,77	teneurin-1	EMX2	10178	2018	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	Human teneurin-1 is a direct target of the homeobox transcription factor EMX2 at a novel alternate promoter .
16876153	0	tenomodulin	49,60	Scleraxis	0,9	tenomodulin	Scleraxis	404530(Tax:9031)	374101(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Scleraxis positively regulates the expression of tenomodulin , a differentiation marker of tenocytes .
19129671	0	tensin2	28,35	nephrin	71,78	tensin2	nephrin	209039(Tax:10090)	54631(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice .
16417922	0	terminal_deoxynucleotidyl_transferase	22,59	CD34	80,84	terminal deoxynucleotidyl transferase	CD34	1791	947	Gene	Gene	expression|amod|START_ENTITY expression|nmod|+ +|compound|END_ENTITY	Evaluation of CD7 and terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- expression in CD34 + myeloblasts from patients with myelodysplastic_syndrome .
7194115	0	terminal_deoxynucleotidyl_transferase	15,52	DNA_polymerase_alpha	58,78	terminal deoxynucleotidyl transferase	DNA polymerase alpha	1791	5422	Gene	Gene	Cooperation|nmod|START_ENTITY Cooperation|nmod|END_ENTITY	Cooperation of terminal_deoxynucleotidyl_transferase with DNA_polymerase_alpha in the replication of ultraviolet-irradiated DNA .
12960389	0	terminal_deoxynucleotidyl_transferase	64,101	Pso4	14,18	terminal deoxynucleotidyl transferase	Pso4	1791	27339	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of human Pso4 in mammalian DNA repair and association with terminal_deoxynucleotidyl_transferase .
1249420	0	terminal_deoxynucleotidyl_transferase	20,57	TdT	59,62	terminal deoxynucleotidyl transferase	TdT	294051(Tax:10116)	294051(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- among subsets of thymocytes in the rat .
1473158	0	terminal_deoxynucleotidyl_transferase	40,77	TdT	79,82	terminal deoxynucleotidyl transferase	TdT	1791	1791	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Immunocytochemical study of recombinant terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- synthesized by baculovirus-infected insect cells .
16417922	0	terminal_deoxynucleotidyl_transferase	22,59	TdT	61,64	terminal deoxynucleotidyl transferase	TdT	1791	1791	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Evaluation of CD7 and terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- expression in CD34 + myeloblasts from patients with myelodysplastic_syndrome .
1841845	0	terminal_deoxynucleotidyl_transferase	22,59	TdT	61,64	terminal deoxynucleotidyl transferase	TdT	1791	1791	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Quantitative assay of terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- activity using monoclonal antibodies .
25999030	0	terminal_deoxynucleotidyl_transferase	35,72	TdT	74,77	terminal deoxynucleotidyl transferase	TdT	1791	1791	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	A luminescence switch-on probe for terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- activity detection by using an iridium -LRB- iii -RRB- - based i-motif probe .
291471	0	terminal_deoxynucleotidyl_transferase	8,45	TdT	47,50	terminal deoxynucleotidyl transferase	TdT	1791	1791	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Loss of terminal_deoxynucleotidyl_transferase -LRB- TdT -RRB- activity as a predictor of emergence of resistance to chemotherapy in a case of chronic_myelogenous_leukemia in blast_crisis .
8514336	0	terminal_deoxynucleotidyltransferase	60,96	TdT	98,101	terminal deoxynucleotidyltransferase	TdT	1791	1791	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Phorbol_ester-induced effects on cell cycle progression and terminal_deoxynucleotidyltransferase -LRB- TdT -RRB- activity in KM-3 pre-B cell line .
8887642	0	terminal_transferase	30,50	Elf-1	21,26	terminal transferase	Elf-1	1791	1997	Gene	Gene	regulation|amod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	A potential role for Elf-1 in terminal_transferase gene regulation .
8217792	0	terminal_transferase	27,47	TdT	49,52	terminal transferase	TdT	1791	1791	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of terminal_transferase -LRB- TdT -RRB- in acute_lymphocytic_leukaemia expressing myeloid antigens and TdT positive acute_myeloid_leukaemia as compared to myeloid antigen negative acute_lymphocytic_leukaemia .
8241275	0	testicular_H1_histone	38,59	H1t	66,69	testicular H1 histone	H1t	107970(Tax:10090)	3010	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and expression of the mouse testicular_H1_histone gene -LRB- H1t -RRB- .
11195349	0	testicular_cell_adhesion_molecule-1	63,98	TCAM-1	100,106	testicular cell adhesion molecule-1	TCAM-1	75870(Tax:10090)	75870(Tax:10090)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Structure , expression , and conserved physical linkage of mouse testicular_cell_adhesion_molecule-1 -LRB- TCAM-1 -RRB- gene .
12748127	0	testicular_haploid_expressed_gene	28,61	Theg	22,26	testicular haploid expressed gene	Theg	21830(Tax:10090)	21830(Tax:10090)	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Male mice lacking the Theg -LRB- testicular_haploid_expressed_gene -RRB- protein undergo normal spermatogenesis and are fertile .
11418599	0	testicular_protein_kinase_2	63,90	Cofilin	0,7	testicular protein kinase 2	Cofilin	10420	1072	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Cofilin phosphorylation and actin reorganization activities of testicular_protein_kinase_2 and its predominant expression in testicular Sertoli cells .
24605775	0	testis-specific_high-mobility-group_protein	8,51	inducible_nitric_oxide_synthase	85,116	testis-specific high-mobility-group protein	inducible nitric oxide synthase	21780(Tax:10090)	18126(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of testis-specific_high-mobility-group_protein in transcriptional regulation of inducible_nitric_oxide_synthase expression in the liver of endotoxic_shock mice .
15599558	0	testis-specific_phosphoglycerate_kinase_2	42,83	PGK2	85,89	testis-specific phosphoglycerate kinase 2	PGK2	396673(Tax:9823)	396673(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of the porcine testis-specific_phosphoglycerate_kinase_2 -LRB- PGK2 -RRB- gene and its association with male fertility .
9705840	0	testis-specific_protein_kinase_1	29,61	TESK1	63,68	testis-specific protein kinase 1	TESK1	29460(Tax:10116)	29460(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Stage-specific expression of testis-specific_protein_kinase_1 -LRB- TESK1 -RRB- in rat spermatogenic cells .
15563848	0	testis-specific_ribbon_protein	55,85	Trib	87,91	testis-specific ribbon protein	Trib	67747(Tax:10090)	67747(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic structure and expression analysis of the mouse testis-specific_ribbon_protein -LRB- Trib -RRB- gene .
8652672	0	testosterone-repressed_prostate_message-2	52,93	TRPM-2	95,101	testosterone-repressed prostate message-2	TRPM-2	24854(Tax:10116)	24854(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Modification of the alternative splicing process of testosterone-repressed_prostate_message-2 -LRB- TRPM-2 -RRB- gene by protein synthesis inhibitors and heat_shock treatment .
9415971	0	testosterone-repressed_prostate_message-2	60,101	TRPM-2	103,109	testosterone-repressed prostate message-2	TRPM-2	1191	1191	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Effect of heat shock treatment on the production of variant testosterone-repressed_prostate_message-2 -LRB- TRPM-2 -RRB- mRNA in culture cells .
20485522	0	tetherin	52,60	BST-2	46,51	tetherin	BST-2	684	684	Gene	Gene	START_ENTITY|amod|/ /|amod|END_ENTITY	The great escape : viral strategies to counter BST-2 / tetherin .
20386718	0	tetherin	14,22	Vpu	55,58	tetherin	Vpu	684	155945(Tax:11676)	Gene	Gene	restriction|compound|START_ENTITY restriction|nmod|release release|nmod|END_ENTITY	Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment .
22530020	0	tetherin	17,25	Vpu	104,107	tetherin	Vpu	684	155945(Tax:11676)	Gene	Gene	activity|amod|START_ENTITY Counteraction|nmod|activity SIVs|nsubj|Counteraction SIVs|xcomp|differing differing|nmod|presence presence|nmod|gene gene|compound|END_ENTITY	Counteraction of tetherin antiviral activity by two closely related SIVs differing by the presence of a Vpu gene .
23284757	0	tetherin	40,48	Vpu	0,3	tetherin	Vpu	684	155945(Tax:11676)	Gene	Gene	envelope|compound|START_ENTITY targets|appos|envelope downmodulates|dobj|targets downmodulates|nsubj|END_ENTITY	Vpu downmodulates two distinct targets , tetherin and gibbon_ape_leukemia_virus envelope , through shared features in the Vpu cytoplasmic tail .
23284757	0	tetherin	40,48	Vpu	120,123	tetherin	Vpu	684	155945(Tax:11676)	Gene	Gene	envelope|compound|START_ENTITY targets|appos|envelope downmodulates|dobj|targets downmodulates|nmod|features features|nmod|tail tail|compound|END_ENTITY	Vpu downmodulates two distinct targets , tetherin and gibbon_ape_leukemia_virus envelope , through shared features in the Vpu cytoplasmic tail .
23633949	0	tetherin	22,30	Vpu	0,3	tetherin	Vpu	684	155945(Tax:11676)	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Vpu binds directly to tetherin and displaces it from nascent virions .
24465210	0	tetherin	16,24	Vpu	67,70	tetherin	Vpu	684	155945(Tax:11676)	Gene	Gene	Preservation|nmod|START_ENTITY counter-activities|nsubj|Preservation counter-activities|advcl|circulating circulating|dobj|alleles alleles|compound|END_ENTITY	Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1_infected individuals .
15480416	0	tetraspanin	35,46	Tsp68C	48,54	tetraspanin	Tsp68C	35614(Tax:7227)	117407(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of Drosophila tetraspanin , Tsp68C , suppresses the abnormal proliferation of ytr-deficient and Ras/Raf-activated hemocytes .
7695637	0	thermolabile_phenol_sulfotransferase	6,42	STM	49,52	thermolabile phenol sulfotransferase	STM	445329	6818	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Human thermolabile_phenol_sulfotransferase gene -LRB- STM -RRB- : molecular cloning and structural characterization .
3162891	0	thermolabile_phenol_sulfotransferase	30,66	TL_PST	68,74	thermolabile phenol sulfotransferase	TL PST	445329	445329	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Inheritance of human platelet thermolabile_phenol_sulfotransferase -LRB- TL_PST -RRB- activity .
2759428	0	thermostable_phenol_sulfotransferase	40,76	TS_PST	78,84	thermostable phenol sulfotransferase	TS PST	6799	6799	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Genetic polymorphism for human platelet thermostable_phenol_sulfotransferase -LRB- TS_PST -RRB- activity .
24874140	0	thiamine_monophosphatase	43,67	TMPase	69,75	thiamine monophosphatase	TMPase	56780(Tax:10116)	56780(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of neonatal capsaicin treatment on thiamine_monophosphatase -LRB- TMPase -RRB- activity in the substantia gelatinosa of the rat spinal cord .
17295612	0	thiamine_pyrophosphokinase	57,83	TPK1	90,94	thiamine pyrophosphokinase	TPK1	27010	27010	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Three common intronic variants in the maternal and fetal thiamine_pyrophosphokinase gene -LRB- TPK1 -RRB- are associated with birth weight .
22993230	0	thioesterase_superfamily_member_1	31,64	Acyl-CoA_thioesterase_11	65,89	thioesterase superfamily member 1	Acyl-CoA thioesterase 11	329910(Tax:10090)	329910(Tax:10090)	Gene	Gene	characterization|nmod|START_ENTITY characterization|dep|END_ENTITY	Functional characterization of thioesterase_superfamily_member_1 / Acyl-CoA_thioesterase_11 : implications for metabolic regulation .
23901139	0	thioesterase_superfamily_member_2	52,85	Phosphatidylcholine_transfer_protein	0,36	thioesterase superfamily member 2	Phosphatidylcholine transfer protein	66834(Tax:10090)	18559(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Phosphatidylcholine_transfer_protein interacts with thioesterase_superfamily_member_2 to attenuate insulin signaling .
1496000	0	thioltransferase	82,98	Glutaredoxin	0,12	thioltransferase	Glutaredoxin	2745	3707602(Tax:10245)	Gene	Gene	activities|amod|START_ENTITY enzyme|nmod|activities enzyme|nsubj|homolog homolog|compound|END_ENTITY	Glutaredoxin homolog encoded by vaccinia_virus is a virion-associated enzyme with thioltransferase and dehydroascorbate reductase activities .
16605247	0	thioltransferase	61,77	glutaredoxin	47,59	thioltransferase	glutaredoxin	2745	2745	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Computational and mutational analysis of human glutaredoxin -LRB- thioltransferase -RRB- : probing the molecular basis of the low pKa of cysteine 22 and its role in catalysis .
18586881	0	thioltransferase	10,26	glutaredoxin	28,40	thioltransferase	glutaredoxin	93692(Tax:10090)	93692(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thioltransferase -LRB- glutaredoxin -RRB- deletion on cellular sensitivity to oxidative stress and cell proliferation in lens epithelial cells of thioltransferase knockout mouse .
2403567	0	thioltransferase	35,51	glutaredoxin	53,65	thioltransferase	glutaredoxin	397463(Tax:9823)	2745	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	High-level expression of pig liver thioltransferase -LRB- glutaredoxin -RRB- in Escherichia_coli .
11043513	0	thiopurine_S-methyltransferase	77,107	TPMT	109,113	thiopurine S-methyltransferase	TPMT	7172	7172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and multiple single-nucleotide polymorphisms -LRB- SNPs -RRB- of the thiopurine_S-methyltransferase -LRB- TPMT -RRB- gene .
16517227	0	thiopurine_S-methyltransferase	17,47	TPMT	49,53	thiopurine S-methyltransferase	TPMT	7172	7172	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Determination of thiopurine_S-methyltransferase -LRB- TPMT -RRB- activity by comparing various normalization factors : reference values for Estonian population using HPLC-UV assay .
9453052	0	thiopurine_S-methyltransferase	45,75	TPMT	77,81	thiopurine S-methyltransferase	TPMT	7172	7172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter and intronic sequences of the human thiopurine_S-methyltransferase -LRB- TPMT -RRB- gene isolated from a human PAC1 genomic library .
9780226	0	thiopurine_S-methyltransferase	41,71	TPMT	73,77	thiopurine S-methyltransferase	TPMT	7172	7172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional characterization of the human thiopurine_S-methyltransferase -LRB- TPMT -RRB- gene promoter .
11337944	0	thiopurine_methyltransferase	28,56	TPMT	58,62	thiopurine methyltransferase	TPMT	7172	7172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelotype frequency of the thiopurine_methyltransferase -LRB- TPMT -RRB- gene in Japanese .
12949626	0	thiopurine_methyltransferase	24,52	TPMT	54,58	thiopurine methyltransferase	TPMT	7172	7172	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic variants of the thiopurine_methyltransferase -LRB- TPMT -RRB- gene in the Colombian population .
16795981	0	thiopurine_methyltransferase	57,85	TPMT	87,91	thiopurine methyltransferase	TPMT	7172	7172	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Choice of azathioprine or 6-mercaptopurine dose based on thiopurine_methyltransferase -LRB- TPMT -RRB- activity to avoid myelosuppression .
10688666	0	thioredoxin	162,173	ASK1	52,56	thioredoxin	ASK1	7295	4217	Gene	Gene	dissociation|nmod|START_ENTITY requires|dobj|dissociation receptor-associated|ccomp|requires receptor-associated|nsubj|Activation Activation|nmod|factor factor|amod|apoptosis_signal-regulating_kinase_1 apoptosis_signal-regulating_kinase_1|dep|END_ENTITY	Activation of apoptosis_signal-regulating_kinase_1 -LRB- ASK1 -RRB- by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin .
25037217	0	thioredoxin	134,145	ASK1	96,100	thioredoxin	ASK1	7295	4217	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Biophysical and structural characterization of the thioredoxin-binding domain of protein kinase ASK1 and its interaction with reduced thioredoxin .
7694770	0	thioredoxin	53,64	ATL-derived_factor	25,43	thioredoxin	ATL-derived factor	7295	7295	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Astroglial expression of ATL-derived_factor , a human thioredoxin homologue , in the gerbil brain after transient global ischemia .
24103856	0	thioredoxin	53,64	Calreticulin	0,12	thioredoxin	Calreticulin	7295	811	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|compound|END_ENTITY	Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular_endothelial_growth_factor in peripheral blood mononuclear cells .
12761212	0	thioredoxin	74,85	ERp18	31,36	thioredoxin	ERp18	7295	51060	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Functional characterization of ERp18 , a new endoplasmic reticulum-located thioredoxin superfamily member .
16677078	0	thioredoxin	47,58	ERp29	0,5	thioredoxin	ERp29	7295	10961	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	ERp29 , an unusual redox-inactive member of the thioredoxin family .
18209488	0	thioredoxin	104,115	IFN-gamma	13,22	thioredoxin	IFN-gamma	7295	3458	Gene	Gene	response|nmod|START_ENTITY regulation|nmod|response Induction|dep|regulation Induction|nmod|expression expression|amod|END_ENTITY	Induction of IFN-gamma gene expression by thioredoxin : positive feed-back regulation of Th1 response by thioredoxin and IFN-gamma .
18209488	0	thioredoxin	42,53	IFN-gamma	13,22	thioredoxin	IFN-gamma	7295	3458	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of IFN-gamma gene expression by thioredoxin : positive feed-back regulation of Th1 response by thioredoxin and IFN-gamma .
1700994	0	thioredoxin	60,71	IL-1_beta	11,20	thioredoxin	IL-1 beta	7295	3553	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of IL-1_beta to alpha-macroglobulins and release by thioredoxin .
11063742	0	thioredoxin	83,94	NF-kappaB	98,107	thioredoxin	NF-kappaB	7295	4790	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	c-Jun NH2-terminal kinase-mediated redox-dependent degradation of IkappaB : role of thioredoxin in NF-kappaB activation .
14669993	0	thioredoxin	82,93	NF-kappaB	21,30	thioredoxin	NF-kappaB	7295	4790	Gene	Gene	levels|nmod|START_ENTITY results|nmod|levels results|nsubj|action action|nmod|END_ENTITY	Suboptimal action of NF-kappaB in Fanconi_anemia cells results from low levels of thioredoxin .
15581626	0	thioredoxin	81,92	NF-kappaB	0,9	thioredoxin	NF-kappaB	7295	4790	Gene	Gene	increase|nmod|START_ENTITY stress|nmod|increase prevents|dobj|stress prevents|nsubj|activation activation|amod|END_ENTITY	NF-kappaB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFalpha-treated Ewing_sarcoma cells .
9388242	0	thioredoxin	34,45	NF-kappaB	60,69	thioredoxin	NF-kappaB	7295	4790	Gene	Gene	role|nmod|START_ENTITY peroxidase|nsubj|role peroxidase|nmod|activation activation|amod|END_ENTITY	Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation .
8127864	0	thioredoxin	20,31	NF-kappa_B	92,102	thioredoxin	NF-kappa B	7295	4790	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa_B and AP-1 .
19470473	0	thioredoxin	20,31	NTRC	0,4	thioredoxin	NTRC	824267(Tax:3702)	818766(Tax:3702)	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	NTRC links built-in thioredoxin to light and sucrose in regulating starch synthesis in chloroplasts and amyloplasts .
17567240	0	thioredoxin	23,34	Nucleoredoxin	0,13	thioredoxin	Nucleoredoxin	7295	64359	Gene	Gene	member|compound|START_ENTITY END_ENTITY|appos|member	Nucleoredoxin , a novel thioredoxin family member involved in cell growth and differentiation .
23901112	0	thioredoxin	46,57	PTP1B	33,38	thioredoxin	PTP1B	7295	5770	Gene	Gene	system|compound|START_ENTITY END_ENTITY|nmod|system	Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-b receptor tyrosine kinase signaling .
8736558	0	thioredoxin	32,43	Ref-1	75,80	thioredoxin	Ref-1	7295	7980	Gene	Gene	START_ENTITY|acl|complexed complexed|nmod|END_ENTITY	The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal .
10781815	0	thioredoxin	16,27	TRX	29,32	thioredoxin	TRX	116484(Tax:10116)	116484(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Upregulation of thioredoxin -LRB- TRX -RRB- expression in giant cell myocarditis in rats .
11407728	0	thioredoxin	6,17	TRX	19,22	thioredoxin	TRX	7295	7295	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum thioredoxin -LRB- TRX -RRB- levels in patients with heart_failure .
21250889	0	thioredoxin	26,37	TRX	39,42	thioredoxin	TRX	7295	7295	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Changes in maternal serum thioredoxin -LRB- TRX -RRB- levels after delivery in preeclamptic and normotensive pregnant women .
18209488	0	thioredoxin	104,115	Th1	88,91	thioredoxin	Th1	7295	51497	Gene	Gene	response|nmod|START_ENTITY response|amod|END_ENTITY	Induction of IFN-gamma gene expression by thioredoxin : positive feed-back regulation of Th1 response by thioredoxin and IFN-gamma .
16766796	0	thioredoxin	19,30	Txnip	36,41	thioredoxin	Txnip	7295	10628	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of thioredoxin with Txnip .
19254690	0	thioredoxin	107,118	Txnip	50,55	thioredoxin	Txnip	7295	10628	Gene	Gene	activity|compound|START_ENTITY contributes|nmod|activity contributes|nsubj|Up-regulation Up-regulation|nmod|thioredoxin_interacting_protein thioredoxin_interacting_protein|appos|END_ENTITY	Up-regulation of thioredoxin_interacting_protein -LRB- Txnip -RRB- by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells .
11306079	0	thioredoxin	33,44	aldose_reductase	48,64	thioredoxin	aldose reductase	280950(Tax:9913)	616199(Tax:9913)	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of bovine small intestine thioredoxin on aldose_reductase activity .
15803370	0	thioredoxin	74,85	bcl-2	10,15	thioredoxin	bcl-2	7295	596	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Antisense bcl-2 transfection up-regulates anti-apoptotic and anti-oxidant thioredoxin in neuroblastoma cells .
18976655	0	thioredoxin	19,30	monocyte_chemoattractant_protein-1	55,89	thioredoxin	monocyte chemoattractant protein-1	7295	6347	Gene	Gene	role|nmod|START_ENTITY role|nmod|secretion secretion|amod|END_ENTITY	Regulatory role of thioredoxin in homocysteine-induced monocyte_chemoattractant_protein-1 secretion in monocytes/macrophages .
24316195	0	thioredoxin	98,109	thioredoxin_3	31,44	thioredoxin	thioredoxin 3	189905(Tax:6239)	187389(Tax:6239)	Gene	Gene	characterization|appos|START_ENTITY characterization|nmod|END_ENTITY	Functional characterization of thioredoxin_3 -LRB- TRX-3 -RRB- , a Caenorhabditis_elegans intestine-specific thioredoxin .
15684606	0	thioredoxin	26,37	thioredoxin_reductase	4,25	thioredoxin	thioredoxin reductase	7295	25824	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	The thioredoxin_reductase / thioredoxin system : novel redox targets for cancer therapy .
16458876	0	thioredoxin	11,22	thioredoxin_reductase	31,52	thioredoxin	thioredoxin reductase	7295	25824	Gene	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	High redox thioredoxin but low thioredoxin_reductase activities in the serum of patients with rheumatoid_arthritis .
20851179	0	thioredoxin	72,83	thioredoxin_reductase	25,46	thioredoxin	thioredoxin reductase	7295	25824	Gene	Gene	protein|compound|START_ENTITY complexes|nmod|protein targeting|dep|complexes targeting|nmod|END_ENTITY	Noble metal targeting of thioredoxin_reductase -- covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin .
22975630	0	thioredoxin	135,146	thioredoxin_reductase	148,169	thioredoxin	thioredoxin reductase	7295	25824	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Methylseleninic_acid -LRB- MSA -RRB- inhibits 17b-estradiol-induced cell growth in breast_cancer T47D cells via enhancement of the antioxidative thioredoxin / thioredoxin_reductase system .
23912593	0	thioredoxin	51,62	thioredoxin_reductase	81,102	thioredoxin	thioredoxin reductase	7295	25824	Gene	Gene	overexpression|nmod|START_ENTITY activity|nmod|overexpression Regulation|nmod|activity independent|nsubj|Regulation independent|nmod|status status|amod|END_ENTITY	Regulation of HIF-1a activity by overexpression of thioredoxin is independent of thioredoxin_reductase status .
2475107	0	thioredoxin	61,72	thioredoxin_reductase	39,60	thioredoxin	thioredoxin reductase	7295	25824	Gene	Gene	transfer|compound|START_ENTITY transfer|amod|END_ENTITY	EF-hands calcium binding regulates the thioredoxin_reductase / thioredoxin electron transfer in human keratinocytes .
21908620	0	thioredoxin	50,61	transglutaminase_2	28,46	thioredoxin	transglutaminase 2	7295	7052	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of extracellular transglutaminase_2 by thioredoxin .
21908620	0	thioredoxin	50,61	transglutaminase_2	28,46	thioredoxin	transglutaminase 2	7295	7052	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of extracellular transglutaminase_2 by thioredoxin .
16263712	0	thioredoxin-1	46,59	Cathepsin_D	0,11	thioredoxin-1	Cathepsin D	7295	1509	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Cathepsin_D and H2O2 stimulate degradation of thioredoxin-1 : implication for endothelial cell apoptosis .
24689038	0	thioredoxin-1	10,23	HSP90	38,43	thioredoxin-1	HSP90	7295	3320	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Decreased thioredoxin-1 and increased HSP90 expression in skeletal muscle in subjects with type 2 diabetes or impaired_glucose_tolerance .
16474438	0	thioredoxin-1	51,64	TRX	66,69	thioredoxin-1	TRX	22166(Tax:10090)	22166(Tax:10090)	Gene	Gene	transgenic_mice|amod|START_ENTITY transgenic_mice|appos|END_ENTITY	Redox regulation of mast cell histamine release in thioredoxin-1 -LRB- TRX -RRB- transgenic_mice .
16207716	0	thioredoxin-1	20,33	interleukin-1beta	70,87	thioredoxin-1	interleukin-1beta	7295	3553	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|dobj|expression expression|amod|END_ENTITY	Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human_monocyte-derived_macrophages .
16624730	0	thioredoxin-binding_protein-2	14,43	vitamin_D3_upregulated_protein-1	44,76	thioredoxin-binding protein-2	vitamin D3 upregulated protein-1	10628	10628	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of thioredoxin-binding_protein-2 / vitamin_D3_upregulated_protein-1 in peripheral blood eosinophils of asthma patients .
24897113	0	thioredoxin-interacting_protein	50,81	Ets1	21,25	thioredoxin-interacting protein	Ets1	56338(Tax:10090)	23871(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transcription factor Ets1 regulates expression of thioredoxin-interacting_protein and inhibits insulin secretion in pancreatic b-cells .
23387972	0	thioredoxin-interacting_protein	46,77	Focal_adhesion_kinase	0,21	thioredoxin-interacting protein	Focal adhesion kinase	10628	5747	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Focal_adhesion_kinase regulates expression of thioredoxin-interacting_protein -LRB- TXNIP -RRB- in cancer cells .
22883233	0	thioredoxin-interacting_protein	14,45	IRE1a	0,5	thioredoxin-interacting protein	IRE1a	56338(Tax:10090)	78943(Tax:10090)	Gene	Gene	induces|xcomp|START_ENTITY induces|nsubj|END_ENTITY	IRE1a induces thioredoxin-interacting_protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress .
22883233	0	thioredoxin-interacting_protein	14,45	NLRP3	62,67	thioredoxin-interacting protein	NLRP3	56338(Tax:10090)	216799(Tax:10090)	Gene	Gene	START_ENTITY|xcomp|activate activate|dobj|inflammasome inflammasome|compound|END_ENTITY	IRE1a induces thioredoxin-interacting_protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress .
25499441	0	thioredoxin-interacting_protein	60,91	NLRP3	92,97	thioredoxin-interacting protein	NLRP3	10628	114548	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting_protein / NLRP3 inflammasome activation with regulation of AMPK in endothelial cells .
12810848	0	thioredoxin-interacting_protein	16,47	TXNIP	49,54	thioredoxin-interacting protein	TXNIP	10628	10628	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Localization of thioredoxin-interacting_protein -LRB- TXNIP -RRB- mRNA in epithelium of human gastrointestinal tract .
22246375	0	thioredoxin-interacting_protein	15,46	TXNIP	48,53	thioredoxin-interacting protein	TXNIP	10628	10628	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of thioredoxin-interacting_protein -LRB- TXNIP -RRB- in glucocorticoid-mediated beta cell death .
26806835	0	thioredoxin-interacting_protein	29,60	TXNIP	62,67	thioredoxin-interacting protein	TXNIP	56338(Tax:10090)	56338(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic regulation of the thioredoxin-interacting_protein -LRB- TXNIP -RRB- gene by hyperglycemia in kidney .
23715727	0	thioredoxin-interacting_protein	11,42	Txnip	44,49	thioredoxin-interacting protein	Txnip	56338(Tax:10090)	56338(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A role for thioredoxin-interacting_protein -LRB- Txnip -RRB- in cellular creatine homeostasis .
23461678	0	thioredoxin-interacting_protein	15,46	insulin	106,113	thioredoxin-interacting protein	insulin	10628	3630	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|resistance resistance|compound|END_ENTITY	Elevated serum thioredoxin-interacting_protein in women with polycystic_ovary_syndrome is associated with insulin resistance .
18528843	0	thioredoxin-like_2	35,53	MC3	97,100	thioredoxin-like 2	MC3	347736	4159	Gene	Gene	Identification|nmod|START_ENTITY END_ENTITY|nsubj|Identification	Identification and distribution of thioredoxin-like_2 as the antigen for the monoclonal antibody MC3 specific to colorectal_cancer .
22492997	0	thioredoxin_1	13,26	DJ-1	0,4	thioredoxin 1	DJ-1	7295	11315	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	DJ-1 induces thioredoxin_1 expression through the Nrf2 pathway .
19165900	0	thioredoxin_2	29,42	TXN2	44,48	thioredoxin 2	TXN2	25828	25828	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic polymorphisms in the thioredoxin_2 -LRB- TXN2 -RRB- gene and risk for spina_bifida .
24316195	0	thioredoxin_3	31,44	thioredoxin	98,109	thioredoxin 3	thioredoxin	187389(Tax:6239)	189905(Tax:6239)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of thioredoxin_3 -LRB- TRX-3 -RRB- , a Caenorhabditis_elegans intestine-specific thioredoxin .
19799861	0	thioredoxin_glutathione_reductase	74,107	retinoic_acid_receptor	48,70	thioredoxin glutathione reductase	retinoic acid receptor	232223(Tax:10090)	19401(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Redox regulation of transcriptional activity of retinoic_acid_receptor by thioredoxin_glutathione_reductase -LRB- TGR -RRB- .
17381501	0	thioredoxin_interacting_protein	21,52	TXNIP	54,59	thioredoxin interacting protein	TXNIP	10628	10628	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic variation in thioredoxin_interacting_protein -LRB- TXNIP -RRB- is associated with hypertriglyceridaemia and blood pressure in diabetes_mellitus .
23454121	0	thioredoxin_interacting_protein	63,94	mTOR	33,37	thioredoxin interacting protein	mTOR	10628	21977(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|compound|END_ENTITY	Mechanistic target of rapamycin -LRB- mTOR -RRB- dependent regulation of thioredoxin_interacting_protein -LRB- TXNIP -RRB- transcription in hypoxia .
11877442	0	thioredoxin_peroxidase-1	54,78	Thioredoxin-2	0,13	thioredoxin peroxidase-1	Thioredoxin-2	53578(Tax:7227)	34281(Tax:7227)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Thioredoxin-2 but not thioredoxin-1 is a substrate of thioredoxin_peroxidase-1 from Drosophila_melanogaster : isolation and characterization of a second thioredoxin in D. _ Melanogaster and evidence for distinct biological functions of Trx-1 and Trx-2 .
12861054	0	thioredoxin_peroxidase-2	55,79	peroxiredoxin-3	38,53	thioredoxin peroxidase-2	peroxiredoxin-3	18477(Tax:10090)	11757(Tax:10090)	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Increased expression of mitochondrial peroxiredoxin-3 -LRB- thioredoxin_peroxidase-2 -RRB- protects cancer cells against hypoxia and drug-induced hydrogen_peroxide-dependent apoptosis .
17671363	0	thioredoxin_peroxidase_1	80,104	Tsa1	106,110	thioredoxin peroxidase 1	Tsa1	854980(Tax:4932)	854980(Tax:4932)	Gene	Gene	form|nmod|START_ENTITY form|appos|END_ENTITY	Crystallization and preliminary X-ray analysis of a decameric form of cytosolic thioredoxin_peroxidase_1 -LRB- Tsa1 -RRB- , C47S mutant , from Saccharomyces_cerevisiae .
2188973	0	thioredoxin_reductase	47,68	Protein_disulfide-isomerase	0,27	thioredoxin reductase	Protein disulfide-isomerase	282885(Tax:9913)	20468271	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Protein_disulfide-isomerase is a substrate for thioredoxin_reductase and has thioredoxin-like activity .
26130523	0	thioredoxin_reductase	4,25	Thioredoxin	28,39	thioredoxin reductase	Thioredoxin	25824	7295	Gene	Gene	START_ENTITY|parataxis|cleaves cleaves|nsubj|system system|compound|END_ENTITY	The thioredoxin_reductase - Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles .
15684606	0	thioredoxin_reductase	4,25	thioredoxin	26,37	thioredoxin reductase	thioredoxin	25824	7295	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	The thioredoxin_reductase / thioredoxin system : novel redox targets for cancer therapy .
16458876	0	thioredoxin_reductase	31,52	thioredoxin	11,22	thioredoxin reductase	thioredoxin	25824	7295	Gene	Gene	activities|amod|START_ENTITY activities|amod|END_ENTITY	High redox thioredoxin but low thioredoxin_reductase activities in the serum of patients with rheumatoid_arthritis .
20851179	0	thioredoxin_reductase	25,46	thioredoxin	72,83	thioredoxin reductase	thioredoxin	25824	7295	Gene	Gene	targeting|nmod|START_ENTITY targeting|dep|complexes complexes|nmod|protein protein|compound|END_ENTITY	Noble metal targeting of thioredoxin_reductase -- covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin .
22975630	0	thioredoxin_reductase	148,169	thioredoxin	135,146	thioredoxin reductase	thioredoxin	25824	7295	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	Methylseleninic_acid -LRB- MSA -RRB- inhibits 17b-estradiol-induced cell growth in breast_cancer T47D cells via enhancement of the antioxidative thioredoxin / thioredoxin_reductase system .
23912593	0	thioredoxin_reductase	81,102	thioredoxin	51,62	thioredoxin reductase	thioredoxin	25824	7295	Gene	Gene	status|amod|START_ENTITY independent|nmod|status independent|nsubj|Regulation Regulation|nmod|activity activity|nmod|overexpression overexpression|nmod|END_ENTITY	Regulation of HIF-1a activity by overexpression of thioredoxin is independent of thioredoxin_reductase status .
2475107	0	thioredoxin_reductase	39,60	thioredoxin	61,72	thioredoxin reductase	thioredoxin	25824	7295	Gene	Gene	transfer|amod|START_ENTITY transfer|compound|END_ENTITY	EF-hands calcium binding regulates the thioredoxin_reductase / thioredoxin electron transfer in human keratinocytes .
15521073	0	thioredoxin_reductase_1	30,53	NF-E2-related_factor-2	115,137	thioredoxin reductase 1	NF-E2-related factor-2	7296	4780	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|dep|role role|nmod|END_ENTITY	Transcriptional regulation of thioredoxin_reductase_1 expression by cadmium in vascular endothelial cells : role of NF-E2-related_factor-2 .
23697945	0	thioredoxin_reductase_1	14,37	NRF2	117,121	thioredoxin reductase 1	NRF2	50493(Tax:10090)	18024(Tax:10090)	Gene	Gene	Disruption|nmod|START_ENTITY protects|nsubj|Disruption protects|nmod|activity activity|compound|END_ENTITY	Disruption of thioredoxin_reductase_1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity .
16219762	0	thioredoxin_reductase_1	107,130	Nrf2	149,153	thioredoxin reductase 1	Nrf2	58819(Tax:10116)	83619(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin_reductase_1 via activation of Nrf2 .
17382897	0	thioredoxin_reductase_1	10,33	glucocorticoid_receptor	37,60	thioredoxin reductase 1	glucocorticoid receptor	7296	2908	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	Effect of thioredoxin_reductase_1 on glucocorticoid_receptor activity in human outer root sheath cells .
25703281	0	thioredoxin_reductase_2	15,38	TXNRD2	40,46	thioredoxin reductase 2	TXNRD2	10587	10587	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of thioredoxin_reductase_2 -LRB- TXNRD2 -RRB- gene polymorphisms with myocardial_infarction in Slovene patients with type_2_diabetes_mellitus .
25231974	0	third_intracellular_loop_determine_anoctamin_1	19,65	TMEM16A	67,74	third intracellular loop determine anoctamin 1	TMEM16A	55107	55107	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Two helices in the third_intracellular_loop_determine_anoctamin_1 -LRB- TMEM16A -RRB- activation by calcium .
15388580	0	thrombin	40,48	ADAMTS13	28,36	thrombin	ADAMTS13	2147	11093	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	Proteolytic inactivation of ADAMTS13 by thrombin and plasmin .
2482548	0	thrombin	63,71	Alpha-2-macroglobulin	0,21	thrombin	Alpha-2-macroglobulin	2147	2	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Alpha-2-macroglobulin is an important progressive inhibitor of thrombin in neonatal and infant plasma .
12195697	0	thrombin	14,22	Antithrombin	65,77	thrombin	Antithrombin	2147	462	Gene	Gene	generation|compound|START_ENTITY Inhibition|nmod|generation Inhibition|nmod|formation formation|appos|I I|compound|END_ENTITY	Inhibition of thrombin generation in plasma by fibrin formation -LRB- Antithrombin I -RRB- .
18292407	0	thrombin	34,42	Antithrombin	0,12	thrombin	Antithrombin	2147	462	Gene	Gene	activity|compound|START_ENTITY increases|dobj|activity increases|nsubj|deficiency deficiency|compound|END_ENTITY	Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass .
3360140	0	thrombin	104,112	Antithrombin	0,12	thrombin	Antithrombin	2147	462	Gene	Gene	activity|compound|START_ENTITY affinity|nmod|activity variant|nmod|affinity Glasgow|dep|variant Glasgow|compound|END_ENTITY	Antithrombin Glasgow , 393_Arg_to_His : a P1 reactive site variant with increased heparin affinity but no thrombin inhibitory activity .
1926061	0	thrombin	41,49	Antithrombin_III	0,16	thrombin	Antithrombin III	280685(Tax:9913)	540261(Tax:9913)	Gene	Gene	effect|nmod|START_ENTITY modulates|dobj|effect modulates|nsubj|END_ENTITY	Antithrombin_III modulates the effect of thrombin on the metabolism of glycosaminoglycans in cultured endothelial cells .
18383370	0	thrombin	30,38	Beta2-glycoprotein_I	0,20	thrombin	Beta2-glycoprotein I	2147	350	Gene	Gene	protects|dobj|START_ENTITY protects|nsubj|END_ENTITY	Beta2-glycoprotein_I protects thrombin from inhibition by heparin_cofactor_II : potentiation of this effect in the presence of anti-beta2-glycoprotein_I autoantibodies .
26045608	0	thrombin	62,70	Cartilage_oligomeric_matrix_protein	0,35	thrombin	Cartilage oligomeric matrix protein	14061(Tax:10090)	12845(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Cartilage_oligomeric_matrix_protein is a natural inhibitor of thrombin .
25212232	0	thrombin	75,83	Disabled-2	0,10	thrombin	Disabled-2	14061(Tax:10090)	13132(Tax:10090)	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|END_ENTITY	Disabled-2 is required for efficient hemostasis and platelet activation by thrombin in mice .
7503720	0	thrombin	67,75	Endothelin-1	0,12	thrombin	Endothelin-1	2147	1906	Gene	Gene	receptor|compound|START_ENTITY internalization|nmod|receptor induces|dobj|internalization induces|nsubj|END_ENTITY	Endothelin-1 induces rapid and long lasting internalization of the thrombin receptor in human glomerular epithelial cells .
22247769	0	thrombin	79,87	Factor_Xa	0,9	thrombin	Factor Xa	2147	2159	Gene	Gene	evaluation|amod|START_ENTITY discriminator|nmod|evaluation generation|dep|discriminator generation|compound|END_ENTITY	Factor_Xa generation by computational modeling : an additional discriminator to thrombin generation evaluation .
13359405	1	thrombin	78,86	Fibrinogen	66,76	thrombin	Fibrinogen	2147	2244	Gene	Gene	albumin|compound|START_ENTITY END_ENTITY|appos|albumin	I. Fibrinogen , thrombin and plasma albumin .
1670992	0	thrombin	30,38	Fibrinogen	0,10	thrombin	Fibrinogen	2147	2244	Gene	Gene	generation|compound|START_ENTITY deposition|nmod|generation deposition|nsubj|END_ENTITY	Fibrinogen deposition without thrombin generation in primary human breast_cancer tissue .
2588959	0	thrombin	163,171	Fibrinogen	0,10	thrombin	Fibrinogen	2147	2244	Gene	Gene	A|nmod|START_ENTITY release|nmod|A arginine-16_by_histidine|nmod|release replacement|nmod|arginine-16_by_histidine characterized|nmod|replacement dysfibrinogenemia|acl|characterized Sapporo|dep|dysfibrinogenemia Sapporo|compound|END_ENTITY	Fibrinogen Sapporo : dysfibrinogenemia characterized by the replacement of A alpha arginine-16_by_histidine resulting in the delayed release of fibrinopeptide A by thrombin .
6236859	0	thrombin	131,139	Fibrinogen	0,10	thrombin	Fibrinogen	2147	2244	Gene	Gene	stimulated|nmod|START_ENTITY complex|acl:relcl|stimulated factor|nmod|complex competes|nmod|factor competes|nsubj|END_ENTITY	Fibrinogen competes with von_Willebrand factor for binding to the glycoprotein IIb/IIIa complex when platelets are stimulated with thrombin .
8091386	0	thrombin	40,48	Fibrinogen	0,10	thrombin	Fibrinogen	2147	2244	Gene	Gene	activation|compound|START_ENTITY marker|nmod|activation levels|nmod|marker levels|amod|END_ENTITY	Fibrinogen plasma levels as a marker of thrombin activation : new insights on the role of fibrinogen as a cardiovascular_risk factor .
8314016	0	thrombin	40,48	Fibrinogen	0,10	thrombin	Fibrinogen	2147	2244	Gene	Gene	activation|compound|START_ENTITY marker|nmod|activation levels|nmod|marker levels|amod|END_ENTITY	Fibrinogen plasma levels as a marker of thrombin activation in diabetes .
989630	0	thrombin	73,81	Fibrinogen	0,10	thrombin	Fibrinogen	2147	2244	Gene	Gene	generation|nmod|START_ENTITY cofactors|nmod|generation END_ENTITY|dep|cofactors	Fibrinogen and its derivatives : cofactors in the intrinsic generation of thrombin .
10349131	0	thrombin	24,32	Heparin_cofactor_II	1,20	thrombin	Heparin Cofactor II	2147	3053	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	-LSB- Heparin_cofactor_II , a thrombin inhibitor with a still not clarified physiologic role -RSB- .
1896960	0	thrombin	55,63	Heparin_cofactor_II	0,19	thrombin	Heparin cofactor II	2147	100009170(Tax:9986)	Gene	Gene	inhibition|nmod|START_ENTITY significance|nmod|inhibition significance|nsubj|END_ENTITY	Heparin_cofactor_II significance for the inhibition of thrombin at the injured vessel wall .
12783117	0	thrombin	72,80	ICAM-1	35,41	thrombin	ICAM-1	2147	3383	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|expression expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- expression is upregulated by thrombin in human monocytes and THP-1 cells in vitro and in pregnant subjects in vivo .
17393023	0	thrombin	68,76	IL-10	9,14	thrombin	IL-10	2147	3586	Gene	Gene	generation|compound|START_ENTITY lipopolysaccharide|dobj|generation produced|xcomp|lipopolysaccharide produced|nsubj|END_ENTITY	Monocyte IL-10 produced in response to lipopolysaccharide modulates thrombin generation by inhibiting tissue factor expression and release of active tissue factor-bound microparticles .
14736878	0	thrombin	53,61	Macrophage_migration_inhibitory_factor	0,38	thrombin	Macrophage migration inhibitory factor	2147	4282	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Macrophage_migration_inhibitory_factor is induced by thrombin and factor_Xa in endothelial cells .
19762781	0	thrombin	46,54	Matrix_metalloproteinase-10	0,27	thrombin	Matrix metalloproteinase-10	2147	4319	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Matrix_metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation .
8093037	0	thrombin	18,26	NF-kappa_B	58,68	thrombin	NF-kappa B	2147	4790	Gene	Gene	signals|amod|START_ENTITY antagonizes|dobj|signals antagonizes|advcl|inhibiting inhibiting|dobj|activation activation|amod|END_ENTITY	E5510 antagonizes thrombin receptor signals by inhibiting NF-kappa_B activation .
9186620	0	thrombin	126,134	NF-kappa_B	19,29	thrombin	NF-kappa B	2147	4790	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Thrombin activates NF-kappa_B through thrombin receptor and results in proliferation of vascular smooth muscle cells : role of thrombin in atherosclerosis and restenosis .
9186620	0	thrombin	38,46	NF-kappa_B	19,29	thrombin	NF-kappa B	2147	4790	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	Thrombin activates NF-kappa_B through thrombin receptor and results in proliferation of vascular smooth muscle cells : role of thrombin in atherosclerosis and restenosis .
10764685	0	thrombin	123,131	PAI-1	144,149	thrombin	PAI-1	2147	5054	Gene	Gene	activity|compound|START_ENTITY activity|nmod|complexes complexes|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
10764685	0	thrombin	18,26	PAI-1	144,149	thrombin	PAI-1	2147	5054	Gene	Gene	Colocalization|nmod|START_ENTITY Colocalization|dep|mechanism mechanism|nmod|activity activity|nmod|complexes complexes|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
12212221	0	thrombin	11,19	PAI-1	84,89	thrombin	PAI-1	2147	5054	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Effect of thrombin on cell proliferation and plasminogen activator inhibitor type -LRB- PAI-1 -RRB- expression in human embryonic glomerular mesangial cells -RSB- .
19359598	0	thrombin	24,32	PAK1	47,51	thrombin	PAK1	2147	5058	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	A role for Gab1/SHP2 in thrombin activation of PAK1 : gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis .
11015310	0	thrombin	19,27	PAR-1	173,178	thrombin	PAR-1	29251(Tax:10116)	25439(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY muscularis|nsubj|modulation muscularis|nmod|END_ENTITY	Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors -LRB- PARs -RRB- : a novel role for PAR-4 as opposed to PAR-1 .
11360179	0	thrombin	4,12	PAR-1	23,28	thrombin	PAR-1	14061(Tax:10090)	14062(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The thrombin receptor , PAR-1 , causes transformation by activation of Rho-mediated signaling pathways .
11591503	0	thrombin	82,90	PAR-1	101,106	thrombin	PAR-1	2147	2149	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor -LRB- PAR-1 -RRB- antagonists .
11672764	0	thrombin	89,97	PAR-1	79,84	thrombin	PAR-1	2147	2149	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|degradation degradation|nmod|receptor receptor|appos|END_ENTITY	Aptamer inhibits degradation of platelet proteolytically activatable receptor , PAR-1 , by thrombin .
14961162	0	thrombin	134,142	PAR-1	153,158	thrombin	PAR-1	2147	2149	Gene	Gene	cleavage|nmod|START_ENTITY due|nmod|cleavage receptor|amod|due receptor|appos|END_ENTITY	Platelets in patients with acute ischemic_stroke are exhausted and refractory to thrombin , due to cleavage of the seven-transmembrane thrombin receptor -LRB- PAR-1 -RRB- .
14961162	0	thrombin	81,89	PAR-1	153,158	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Platelets in patients with acute ischemic_stroke are exhausted and refractory to thrombin , due to cleavage of the seven-transmembrane thrombin receptor -LRB- PAR-1 -RRB- .
15317288	0	thrombin	62,70	PAR-1	112,117	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Discovery of potent peptide-mimetic antagonists for the human thrombin receptor , protease-activated_receptor-1 -LRB- PAR-1 -RRB- .
18005014	0	thrombin	12,20	PAR-1	62,67	thrombin	PAR-1	2147	2149	Gene	Gene	gene|compound|START_ENTITY gene|dep|receptor receptor|appos|END_ENTITY	Effect of a thrombin receptor -LRB- protease-activated receptor 1 , PAR-1 -RRB- gene polymorphism in chronic hepatitis_C liver_fibrosis .
18570113	0	thrombin	23,31	PAR-1	42,47	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Over-expression of the thrombin receptor -LRB- PAR-1 -RRB- in the placenta in preeclampsia : a mechanism for the intersection of coagulation and inflammation .
18612544	0	thrombin	52,60	PAR-1	31,36	thrombin	PAR-1	2147	2149	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Protease_activated_receptor_1 -LRB- PAR-1 -RRB- activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial_protein_C_receptor is occupied by its natural ligand .
19705342	0	thrombin	14,22	PAR-1	33,38	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	SCH-530348 , a thrombin receptor -LRB- PAR-1 -RRB- antagonist for the prevention and treatment of atherothrombosis .
19882073	0	thrombin	113,121	PAR-1	156,161	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY antagonist|nsubj|receptor antagonist|nmod|END_ENTITY	Improving antiplatelet therapy for atherothrombotic_disease : preclinical results with SCH_530348 , the first oral thrombin receptor antagonist selective for PAR-1 .
24435325	0	thrombin	15,23	PAR-1	59,64	thrombin	PAR-1	2147	2149	Gene	Gene	potential|compound|START_ENTITY potential|nmod|regulation regulation|compound|END_ENTITY	Association of thrombin generation potential with platelet PAR-1 regulation and P-selectin expression in patients on dual antiplatelet therapy .
9308764	0	thrombin	101,109	PAR-1	34,39	thrombin	PAR-1	2147	2149	Gene	Gene	activated|nmod|START_ENTITY platelets|acl|activated surface|nmod|platelets N-terminus|nmod|surface N-terminus|nsubj|Release Release|appos|END_ENTITY	Release of the thrombin receptor -LRB- PAR-1 -RRB- N-terminus from the surface of human platelets activated by thrombin .
9308764	0	thrombin	15,23	PAR-1	34,39	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY Release|nmod|receptor Release|appos|END_ENTITY	Release of the thrombin receptor -LRB- PAR-1 -RRB- N-terminus from the surface of human platelets activated by thrombin .
9486128	0	thrombin	64,72	PAR-1	83,88	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Protein kinase C beta regulates heterologous desensitization of thrombin receptor -LRB- PAR-1 -RRB- in endothelial cells .
9721728	0	thrombin	56,64	PAR-1	75,80	thrombin	PAR-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Injury-related factors and conditions down-regulate the thrombin receptor -LRB- PAR-1 -RRB- in a human neuronal cell line .
9886918	0	thrombin	52,60	PAR-1	71,76	thrombin	PAR-1	2147	2149	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Time course of recovery of endothelial cell surface thrombin receptor -LRB- PAR-1 -RRB- expression .
11015310	0	thrombin	19,27	PAR-4	153,158	thrombin	PAR-4	29251(Tax:10116)	116498(Tax:10116)	Gene	Gene	modulation|nmod|START_ENTITY muscularis|nsubj|modulation muscularis|dobj|mucosae mucosae|dep|role role|nmod|END_ENTITY	Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors -LRB- PARs -RRB- : a novel role for PAR-4 as opposed to PAR-1 .
24990321	0	thrombin	32,40	PAR-4	50,55	thrombin	PAR-4	2147	347745	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes .
10205017	0	thrombin	38,46	PAR1	101,105	thrombin	PAR1	29251(Tax:10116)	25439(Tax:10116)	Gene	Gene	actions|nmod|START_ENTITY actions|dep|role role|nmod|proteinase-activated_receptor-1 proteinase-activated_receptor-1|appos|END_ENTITY	Pro- and anti-inflammatory actions of thrombin : a distinct role for proteinase-activated_receptor-1 -LRB- PAR1 -RRB- .
11005807	0	thrombin	41,49	PAR1	36,40	thrombin	PAR1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Substrate-assisted catalysis of the PAR1 thrombin receptor .
12563219	0	thrombin	101,109	PAR1	23,27	thrombin	PAR1	2147	2149	Gene	Gene	stimulant|advcl|START_ENTITY stimulant|nsubj|peptide peptide|nmod|END_ENTITY	The cleaved peptide of PAR1 is a more potent stimulant of platelet-endothelial cell adhesion than is thrombin .
15262827	0	thrombin	47,55	PAR1	66,70	thrombin	PAR1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY inhibition|nmod|receptor inhibition|appos|END_ENTITY	Clinical inhibition of the seven-transmembrane thrombin receptor -LRB- PAR1 -RRB- by intravenous aprotinin during cardiothoracic surgery .
17595115	0	thrombin	15,23	PAR1	29,33	thrombin	PAR1	2147	2149	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site .
17595115	0	thrombin	50,58	PAR1	29,33	thrombin	PAR1	2147	2149	Gene	Gene	site|compound|START_ENTITY Interaction|nmod|site Interaction|nmod|END_ENTITY	Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site .
18293826	0	thrombin	4,12	PAR1	13,17	thrombin	PAR1	2147	2149	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Why thrombin PAR1 receptors are important to the cardiac surgical patient .
20236938	0	thrombin	21,29	PAR1	79,83	thrombin	PAR1	2147	2149	Gene	Gene	structure|nmod|START_ENTITY bound|nsubj|structure bound|nmod|fragment fragment|nmod|END_ENTITY	Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1 .
18398001	0	thrombin	11,19	PI3K	38,42	thrombin	PI3K	14061(Tax:10090)	18708(Tax:10090)	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells .
7665170	0	thrombin	24,32	PI7	44,47	thrombin	PI7	2147	5270	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	The gene for the serpin thrombin inhibitor -LRB- PI7 -RRB- , protease_nexin_I , is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes .
25118676	0	thrombin	135,143	PLA2	26,30	thrombin	PLA2	2147	151056	Gene	Gene	inhibit|dobj|START_ENTITY different|xcomp|inhibit exhibit|xcomp|different exhibit|nsubj|isoenzymes isoenzymes|compound|END_ENTITY	Two acidic , anticoagulant PLA2 isoenzymes purified from the venom of monocled cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor_Xa via phospholipids independent , non-enzymatic mechanism .
9139985	0	thrombin	64,72	PLA2	104,108	thrombin	PLA2	2147	151056	Gene	Gene	activation|compound|START_ENTITY activation|dep|END_ENTITY	Lysophosphatidylcholine accumulation in cardiomyocytes requires thrombin activation of Ca2 + - independent PLA2 .
11084032	0	thrombin	11,19	Par-1	69,74	thrombin	Par-1	2147	145624	Gene	Gene	Binding|nmod|START_ENTITY accelerates|nsubj|Binding accelerates|dobj|hydrolysis hydrolysis|nmod|END_ENTITY	Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets .
19189342	0	thrombin	39,47	Par-1	73,78	thrombin	Par-1	2147	2149	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase .
24969778	0	thrombin	76,84	Platelet_endothelial_cell_adhesion_molecule-1	0,45	thrombin	Platelet endothelial cell adhesion molecule-1	14061(Tax:10090)	18613(Tax:10090)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Platelet_endothelial_cell_adhesion_molecule-1 inhibits platelet response to thrombin and von_Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3 / dynamin and integrin aIIbb3 .
21041299	0	thrombin	120,128	Platelet_factor_4	0,17	thrombin	Platelet factor 4	2147	5196	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Platelet_factor_4 inhibits thrombomodulin-dependent activation of thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- by thrombin .
14632180	0	thrombin	31,39	Protease-activated_receptor-1	0,29	thrombin	Protease-activated receptor-1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Protease-activated_receptor-1 -LRB- thrombin receptor -RRB- is expressed in mesenchymal portions of human hair follicle .
10079109	0	thrombin	78,86	Protease-activated_receptors_1_and_4	0,36	thrombin	Protease-activated receptors 1 and 4	2147	2149;9002	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Protease-activated_receptors_1_and_4 mediate activation of human platelets by thrombin .
18612544	0	thrombin	52,60	Protease_activated_receptor_1	0,29	thrombin	Protease activated receptor 1	2147	2149	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Protease_activated_receptor_1 -LRB- PAR-1 -RRB- activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial_protein_C_receptor is occupied by its natural ligand .
7704602	0	thrombin	27,35	Protease_nexin-1	0,16	thrombin	Protease nexin-1	2147	5270	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Protease_nexin-1 , a potent thrombin inhibitor , is reduced around cerebral blood vessels in Alzheimer 's _ disease .
8360185	0	thrombin	20,28	Protease_nexin-1	0,16	thrombin	Protease nexin-1	2147	5270	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Protease_nexin-1 , a thrombin inhibitor , is regulated by interleukin-1_and_dexamethasone in normal human fibroblasts .
16484615	0	thrombin	154,162	Sgk-1	47,52	thrombin	Sgk-1	14061(Tax:10090)	20393(Tax:10090)	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	The serum - and glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary_vascular_remodeling : role in redox-sensitive regulation of tissue factor by thrombin .
12614335	0	thrombin	63,71	Src	56,59	thrombin	Src	29251(Tax:10116)	83805(Tax:10116)	Gene	Gene	signalling|compound|START_ENTITY END_ENTITY|nmod|signalling	The role of the Ca2 + - sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes .
7831680	0	thrombin	30,38	TFPI	22,26	thrombin	TFPI	2147	7035	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	Inhibitory effects of TFPI on thrombin and factor_Xa generation in vitro -- modulatory action of glycosaminoglycans .
12467301	0	thrombin	48,56	Thrombin	0,8	thrombin	Thrombin	2147	2147	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|dep|activation	Thrombin as a survival factor for cancer cells : thrombin activation in malignant effusions in vivo and inhibition of idarubicin-induced cell death in vitro .
11257732	0	thrombin	28,36	Thrombomodulin	0,14	thrombin	Thrombomodulin	2147	7056	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Thrombomodulin -- endothelial thrombin receptor in blood of patients with unstable angina_pectoris .
1320301	0	thrombin	33,41	Thrombomodulin	0,14	thrombin	Thrombomodulin	100009146(Tax:9986)	100008887(Tax:9986)	Gene	Gene	degradation|compound|START_ENTITY cofactor|nmod|degradation cofactor|nsubj|END_ENTITY	Thrombomodulin is a cofactor for thrombin degradation of recombinant single-chain urokinase plasminogen activator `` in vitro '' and in a perfused rabbit heart model .
14523228	0	thrombin	74,82	Thrombomodulin	0,14	thrombin	Thrombomodulin	2147	7056	Gene	Gene	activity|nmod|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin .
16274226	0	thrombin	28,36	Thrombomodulin	0,14	thrombin	Thrombomodulin	2147	7056	Gene	Gene	loops|amod|START_ENTITY tightens|dobj|loops tightens|nsubj|END_ENTITY	Thrombomodulin tightens the thrombin active site loops to promote protein C activation .
21788337	0	thrombin	80,88	Thrombomodulin	0,14	thrombin	Thrombomodulin	14061(Tax:10090)	21824(Tax:10090)	Gene	Gene	domain|compound|START_ENTITY linked|nmod|domain mechanism|acl|linked metastasis|nmod|mechanism determinant|nmod|metastasis determinant|nsubj|END_ENTITY	Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain .
22178578	0	thrombin	62,70	Thrombomodulin	0,14	thrombin	Thrombomodulin	14061(Tax:10090)	21824(Tax:10090)	Gene	Gene	W215A/E217A|amod|START_ENTITY activity|nmod|W215A/E217A required|nmod|activity required|nsubjpass|END_ENTITY	Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial_thrombosis .
6313646	0	thrombin	37,45	Thrombomodulin	0,14	thrombin	Thrombomodulin	2147	7056	Gene	Gene	ability|nmod|START_ENTITY blocks|dobj|ability blocks|nsubj|END_ENTITY	Thrombomodulin blocks the ability of thrombin to activate platelets .
9425093	0	thrombin	37,45	Thrombomodulin	0,14	thrombin	Thrombomodulin	2147	7056	Gene	Gene	inhibition|compound|START_ENTITY rate|nmod|inhibition increases|dobj|rate increases|nsubj|END_ENTITY	Thrombomodulin increases the rate of thrombin inhibition by BPTI .
9569203	0	thrombin	51,59	Thrombomodulin	0,14	thrombin	Thrombomodulin	2147	7056	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Thrombomodulin modulates the mitogenic response to thrombin of human umbilical vein endothelial cells .
21515313	0	thrombin	48,56	Tissue_factor_pathway_inhibitor_2	0,33	thrombin	Tissue factor pathway inhibitor 2	2147	7980	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Tissue_factor_pathway_inhibitor_2 is induced by thrombin in human macrophages .
137671	0	thrombin	32,40	VIII	69,73	thrombin	VIII	2147	1351	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|END_ENTITY	In vivo and in vitro effects of thrombin and plasmin on human factor VIII -LRB- AHF -RRB- .
24354535	0	thrombin	131,139	VIII	96,100	thrombin	VIII	2147	1351	Gene	Gene	generation|compound|START_ENTITY correlation|nmod|generation concentrate|dobj|correlation concentrate|nsubj|scores scores|nmod|cohort cohort|nmod|Pakistan Pakistan|nmod|access access|nmod|factor factor|nummod|END_ENTITY	Joint health scores in a haemophilia_A cohort from Pakistan with minimal or no access to factor VIII concentrate : correlation with thrombin generation and underlying mutation .
3082357	1	thrombin	82,90	VIII	170,174	thrombin	VIII	2147	1351	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|activity activity|nummod|END_ENTITY	Correlation of specific cleavages by thrombin , factor_Xa , and activated_protein_C with activation and inactivation of factor VIII coagulant activity .
3085715	0	thrombin	71,79	VIII	25,29	thrombin	VIII	2147	1351	Gene	Gene	produced|nmod|START_ENTITY produced|nsubj|size size|nmod|heterodimers heterodimers|compound|END_ENTITY	The size of human factor VIII heterodimers and the effects produced by thrombin .
3099625	2	thrombin	116,124	VIII	96,100	thrombin	VIII	2147	1351	Gene	Gene	proteolysis|nmod|START_ENTITY proteolysis|nummod|END_ENTITY	Antibody binding prevents factor VIII proteolysis by thrombin .
505400	0	thrombin	17,25	VIII	79,83	thrombin	VIII	2147	1351	Gene	Gene	influence|nmod|START_ENTITY influence|nmod|activity activity|nmod|END_ENTITY	The influence of thrombin on the platelet-aggregating activity of human factor VIII .
505401	0	thrombin	76,84	VIII	23,27	thrombin	VIII	2147	1351	Gene	Gene	generation|nmod|START_ENTITY independent|nmod|generation END_ENTITY|nmod|independent	Inactivation of factor VIII by a mechanism independent of the generation of thrombin .
6778941	0	thrombin	14,22	VIII	39,43	thrombin	VIII	2147	1351	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of thrombin on human factor VIII .
6779877	0	thrombin	90,98	VIII	48,52	thrombin	VIII	2147	1351	Gene	Gene	inhibitors|nmod|START_ENTITY effect|nmod|inhibitors activation|dep|effect activation|nmod|END_ENTITY	The activation and inactivation of human factor VIII by thrombin : effect of inhibitors of thrombin .
6794678	0	thrombin	97,105	VIII	78,82	thrombin	VIII	2147	1351	Gene	Gene	activation|nmod|START_ENTITY activation|nummod|END_ENTITY	Combined factor V-VIII deficiency : a case report with studies of factor V and VIII activation by thrombin .
8907177	0	thrombin	109,117	VIII	88,92	thrombin	VIII	2147	1351	Gene	Gene	V|nmod|START_ENTITY V|nsubj|Effect Effect|nmod|glycosaminoglycan glycosaminoglycan|nmod|activation activation|nmod|END_ENTITY	Effect of depolymerized holothurian glycosaminoglycan -LRB- DHG -RRB- on the activation of factor VIII and factor V by thrombin .
6193011	0	thrombin	53,61	alpha_2-macroglobulin	30,51	thrombin	alpha 2-macroglobulin	2147	2	Gene	Gene	complex|compound|START_ENTITY complex|amod|END_ENTITY	Structural arrangement in the alpha_2-macroglobulin -- thrombin complex .
10037709	0	thrombin	62,70	antithrombin	108,120	thrombin	antithrombin	2147	462	Gene	Gene	protection|nmod|START_ENTITY essential|nmod|protection essential|nmod|END_ENTITY	Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II .
10064273	0	thrombin	41,49	antithrombin	11,23	thrombin	antithrombin	2147	462	Gene	Gene	generation|compound|START_ENTITY Effects|nmod|generation Effects|nmod|END_ENTITY	Effects of antithrombin and protein_C on thrombin generation in newborn and adult plasma .
10691099	0	thrombin	28,36	antithrombin	94,106	thrombin	antithrombin	2147	462	Gene	Gene	generation|compound|START_ENTITY modulation|nmod|generation associated|nsubj|modulation associated|nmod|END_ENTITY	Pharmacologic modulation of thrombin generation associated with human clots by human purified antithrombin alone or in the presence of low molecular weight heparin or unfractionated heparin .
10784436	0	thrombin	16,24	antithrombin	57,69	thrombin	antithrombin	2147	462	Gene	Gene	activity|amod|START_ENTITY inhibited|nsubjpass|activity inhibited|nmod|END_ENTITY	Most clot-bound thrombin activity is inhibited by plasma antithrombin during clot aging , but a very small fraction survives .
11278930	0	thrombin	53,61	antithrombin	36,48	thrombin	antithrombin	2147	462	Gene	Gene	independent|compound|START_ENTITY END_ENTITY|nmod|independent	Heparin enhances the specificity of antithrombin for thrombin and factor_Xa independent of the reactive center loop sequence .
11739542	0	thrombin	116,124	antithrombin	128,140	thrombin	antithrombin	2147	462	Gene	Gene	inactivation|nmod|START_ENTITY interfere|nmod|inactivation interfere|nmod|END_ENTITY	Identification of anti-thrombin antibodies in the antiphospholipid_syndrome that interfere with the inactivation of thrombin by antithrombin .
12871499	0	thrombin	92,100	antithrombin	61,73	thrombin	antithrombin	2147	462	Gene	Gene	generation|compound|START_ENTITY allows|dobj|generation allows|advmod|together together|nmod|END_ENTITY	Low tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- together with low antithrombin allows sufficient thrombin generation in neonates .
16078853	0	thrombin	75,83	antithrombin	48,60	thrombin	antithrombin	2147	462	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|compound|END_ENTITY	Mechanism of poly -LRB- acrylic_acid -RRB- acceleration of antithrombin inhibition of thrombin : implications for the design of novel heparin mimics .
16413239	0	thrombin	40,48	antithrombin	18,30	thrombin	antithrombin	2147	462	Gene	Gene	formation|amod|START_ENTITY inhibits|iobj|formation inhibits|nsubj|END_ENTITY	Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia .
16856890	0	thrombin	51,59	antithrombin	120,132	thrombin	antithrombin	2147	462	Gene	Gene	inhibitor|compound|START_ENTITY Comparison|nmod|inhibitor Comparison|nmod|deficiency deficiency|compound|END_ENTITY	Comparison of the anticoagulant effect of a direct thrombin inhibitor and a low molecular weight heparin in an acquired antithrombin deficiency in children with acute_lymphoblastic_leukaemia treated with L-asparaginase : an in vitro study .
17689549	0	thrombin	71,79	antithrombin	83,95	thrombin	antithrombin	2147	462	Gene	Gene	START_ENTITY|nmod|DNA DNA|compound|END_ENTITY	Surface plasmon resonance spectroscopy study of interfacial binding of thrombin to antithrombin DNA aptamers .
18180618	0	thrombin	201,209	antithrombin	18,30	thrombin	antithrombin	2147	462	Gene	Gene	II|nmod|START_ENTITY directing|nmod|II existence|dep|directing existence|nmod|antibody antibody|compound|END_ENTITY	Sole existence of antithrombin antibody in patients with systemic_lupus_erythematosus showing tendency of its antigenic determinants directing against exosite II -LRB- antithrombin/heparin binding site -RRB- of thrombin .
22978548	0	thrombin	139,147	antithrombin	167,179	thrombin	antithrombin	2147	462	Gene	Gene	protects|dobj|START_ENTITY protects|nmod|END_ENTITY	By increasing the affinity of heparin for fibrin , Zn -LRB- 2 + -RRB- promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin .
25402190	0	thrombin	52,60	antithrombin	102,114	thrombin	antithrombin	2147	462	Gene	Gene	generation|compound|START_ENTITY increase|nmod|generation increase|acl:relcl|correlated correlated|nmod|levels levels|compound|END_ENTITY	Patients with cirrhosis show a relative increase in thrombin generation that is correlated with lower antithrombin levels .
3584126	1	thrombin	81,89	antithrombin	149,161	thrombin	antithrombin	2147	462	Gene	Gene	cleavage|nmod|START_ENTITY induce|dep|cleavage induce|nmod|region region|nmod|END_ENTITY	I. Does cleavage by thrombin induce structural changes in the heparin-binding region of antithrombin ?
3584127	2	thrombin	161,169	antithrombin	113,125	thrombin	antithrombin	2147	462	Gene	Gene	inactivation|nmod|START_ENTITY required|nmod|inactivation END_ENTITY|acl|required	Is the heparin-induced conformational change in antithrombin required for rapid inactivation of thrombin ?
3955055	0	thrombin	71,79	antithrombin	83,95	thrombin	antithrombin	2147	462	Gene	Gene	inhibition|nmod|START_ENTITY regulate|dobj|inhibition regulate|nmod|END_ENTITY	Thrombin-reactive polypeptides of platelets may regulate inhibition of thrombin by antithrombin .
4052633	0	thrombin	30,38	antithrombin	42,54	thrombin	antithrombin	2147	462	Gene	Gene	kinetics|nmod|START_ENTITY kinetics|nmod|END_ENTITY	The kinetics of inhibition of thrombin by antithrombin in the presence of components of the hemostatic system .
5932766	0	thrombin	20,28	antithrombin	56,68	thrombin	antithrombin	2147	462	Gene	Gene	time|compound|START_ENTITY time|amod|due due|nmod|END_ENTITY	-LSB- Lengthening of the thrombin time due to an anti-equine antithrombin in a case of hyperthrombocytic myelosis -RSB- .
6688430	1	thrombin	120,128	antithrombin	143,155	thrombin	antithrombin	2147	462	Gene	Gene	inhibition|compound|START_ENTITY domains|nmod|inhibition charge|dobj|domains charge|nmod|END_ENTITY	Independence of heparin charge density and antithrombin-binding domains in thrombin inhibition by antithrombin and heparin_cofactor_II .
7364749	0	thrombin	69,77	antithrombin	20,32	thrombin	antithrombin	2147	462	Gene	Gene	inactivation|compound|START_ENTITY required|nmod|inactivation required|nsubjpass|bond bond|nmod|END_ENTITY	A disulfide bond in antithrombin is required for heparin-accelerated thrombin inactivation .
7974394	0	thrombin	51,59	antithrombin	21,33	thrombin	antithrombin	2147	462	Gene	Gene	generation|compound|START_ENTITY concentration|nmod|generation concentration|compound|END_ENTITY	The effect of plasma antithrombin concentration on thrombin generation and fibrin gel structure .
8136018	0	thrombin	15,23	antithrombin	29,41	thrombin	antithrombin	2147	462	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin with antithrombin , heparin_cofactor_II , and protein_C_inhibitor .
8288594	0	thrombin	47,55	antithrombin	104,116	thrombin	antithrombin	2147	462	Gene	Gene	residues|nmod|START_ENTITY Identification|nmod|residues essential|nsubj|Identification essential|nmod|III III|compound|END_ENTITY	Identification of basic amino_acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III .
8987163	0	thrombin	14,22	antithrombin	75,87	thrombin	antithrombin	2147	462	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|amod|fused fused|nmod|END_ENTITY	Inhibition of thrombin by hirudin genetically fused to wild-type or mutant antithrombin .
9031720	0	thrombin	13,21	antithrombin	36,48	thrombin	antithrombin	2147	462	Gene	Gene	Mechanism|nmod|START_ENTITY inhibition|nsubj|Mechanism inhibition|nmod|END_ENTITY	Mechanism of thrombin inhibition by antithrombin and heparin_cofactor_II in the presence of heparin .
9214615	0	thrombin	4,12	antithrombin	111,123	thrombin	antithrombin	2147	462	Gene	Gene	complex|compound|START_ENTITY reveals|nsubj|complex reveals|dobj|rearrangements rearrangements|dep|implications implications|nmod|interaction interaction|nmod|END_ENTITY	The thrombin E192Q-BPTI complex reveals gross structural rearrangements : implications for the interaction with antithrombin and thrombomodulin .
9361370	0	thrombin	84,92	antithrombin	66,78	thrombin	antithrombin	2147	462	Gene	Gene	positions|nmod|START_ENTITY positions|nmod|reaction reaction|nmod|END_ENTITY	Impact of mutations at the P4_and_P5 positions on the reaction of antithrombin with thrombin and elastase .
8473344	0	thrombin	34,42	antithrombin-III	82,98	thrombin	antithrombin-III	2147	462	Gene	Gene	Dissociation|nmod|START_ENTITY Dissociation|nmod|END_ENTITY	Dissociation of heparin-dependent thrombin and factor_Xa inhibitory activities of antithrombin-III by mutations in the reactive site .
11051806	0	thrombin	78,86	antithrombin_III	38,54	thrombin	antithrombin III	2147	462	Gene	Gene	methods|compound|START_ENTITY measured|nmod|methods measured|nsubj|Effect Effect|nmod|heparin_cofactor_II heparin_cofactor_II|nmod|activities activities|amod|END_ENTITY	-LSB- Effect of heparin_cofactor_II on the antithrombin_III activities measured by thrombin methods or factor_Xa methods -- fundamental studies and clinical studies using the plasma of pregnant women -RSB- .
2020936	0	thrombin	70,78	antithrombin_III	11,27	thrombin	antithrombin III	100144442(Tax:9823)	100125972(Tax:9823)	Gene	Gene	inhibitor|nmod|START_ENTITY complex|nmod|inhibitor END_ENTITY|dep|complex	A purified antithrombin_III -- heparin complex as a potent inhibitor of thrombin in porcine endotoxin shock .
2081384	0	thrombin	19,27	antithrombin_III	100,116	thrombin	antithrombin III	2147	462	Gene	Gene	time|compound|START_ENTITY Sensitivity|nmod|time Sensitivity|nmod|END_ENTITY	Sensitivity of the thrombin clotting time and activated partial thromboplastin time to low level of antithrombin_III during heparin therapy .
2154059	0	thrombin	58,66	antithrombin_III	76,92	thrombin	antithrombin III	2147	462	Gene	Gene	inactivation|nmod|START_ENTITY effect|nmod|inactivation effect|nmod|END_ENTITY	The effect of human thrombomodulin on the inactivation of thrombin by human antithrombin_III .
2476159	0	thrombin	80,88	antithrombin_III	139,155	thrombin	antithrombin III	2147	462	Gene	Gene	inactivation|nmod|START_ENTITY sulfate|nmod|inactivation sulfate|nmod|END_ENTITY	The molecular-mass dependence of dextran sulfate enhancement of inactivation of thrombin and fibrinogen and on factor_Xa neutralization by antithrombin_III .
2910581	0	thrombin	94,102	antithrombin_III	123,139	thrombin	antithrombin III	2147	462	Gene	Gene	assay|compound|START_ENTITY assay|nmod|END_ENTITY	Increased concentrations of heparin cofactor II in diabetic patients , and possible effects on thrombin inhibition assay of antithrombin_III .
2973155	0	thrombin	18,26	antithrombin_III	30,46	thrombin	antithrombin III	2147	462	Gene	Gene	Neutralization|nmod|START_ENTITY Neutralization|nmod|END_ENTITY	Neutralization of thrombin by antithrombin_III in the presence of cultured human fibroblasts .
3754869	1	thrombin	108,116	antithrombin_III	135,151	thrombin	antithrombin III	2147	462	Gene	Gene	Protection|nmod|START_ENTITY Protection|nmod|inactivation inactivation|amod|END_ENTITY	Protection of thrombin by S-protein from antithrombin_III inactivation .
3790599	0	thrombin	106,114	antithrombin_III	89,105	thrombin	antithrombin III	280685(Tax:9913)	540261(Tax:9913)	Gene	Gene	reaction|compound|START_ENTITY /|dobj|reaction /|nsubj|Comparison Comparison|nmod|behavior behavior|nmod|proteins proteins|nmod|END_ENTITY	Comparison of the kinetic behavior of human and bovine proteins in the heparin-catalyzed antithrombin_III / thrombin reaction .
6166063	0	thrombin	66,74	antithrombin_III	20,36	thrombin	antithrombin III	2147	462	Gene	Gene	inactivation|compound|START_ENTITY roles|nmod|inactivation roles|nmod|END_ENTITY	Respective roles of antithrombin_III and alpha_2_macroglobulin in thrombin inactivation .
6209818	0	thrombin	73,81	antithrombin_III	56,72	thrombin	antithrombin III	2147	462	Gene	Gene	reaction|compound|START_ENTITY reaction|nmod|Abolition Abolition|nmod|sulfate sulfate|nmod|END_ENTITY	Abolition by dextran sulfate of the heparin-accelerated antithrombin_III / thrombin reaction .
6719385	0	thrombin	31,39	antithrombin_III	51,67	thrombin	antithrombin III	2147	462	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of immobilized thrombin with human antithrombin_III .
7540283	0	thrombin	67,75	antithrombin_III	46,62	thrombin	antithrombin III	2147	462	Gene	Gene	regulation|compound|START_ENTITY END_ENTITY|nmod|regulation	alpha_2-Macroglobulin remains as important as antithrombin_III for thrombin regulation in cord plasma in the presence of endothelial cell surfaces .
8259541	0	thrombin	124,132	antithrombin_III	70,86	thrombin	antithrombin III	2147	462	Gene	Gene	associates|nmod|START_ENTITY END_ENTITY|dep|associates	Recombinant human soluble thrombomodulin delivers bounded thrombin to antithrombin_III : thrombomodulin associates with free thrombin and is recycled to activate protein_c .
8259541	0	thrombin	58,66	antithrombin_III	70,86	thrombin	antithrombin III	2147	462	Gene	Gene	delivers|dobj|START_ENTITY delivers|nmod|END_ENTITY	Recombinant human soluble thrombomodulin delivers bounded thrombin to antithrombin_III : thrombomodulin associates with free thrombin and is recycled to activate protein_c .
8286739	0	thrombin	21,29	antithrombin_III	147,163	thrombin	antithrombin III	2147	462	Gene	Gene	generation|compound|START_ENTITY generation|dep|risk risk|nmod|thrombotic_complications thrombotic_complications|nmod|deficiency deficiency|compound|END_ENTITY	Increased endogenous thrombin generation in children with acute_lymphoblastic_leukemia : risk of thrombotic_complications in L'Asparaginase-induced antithrombin_III deficiency .
8470046	0	thrombin	160,168	antithrombin_III	109,125	thrombin	antithrombin III	2147	462	Gene	Gene	inhibition|compound|START_ENTITY based|nmod|inhibition assay|acl|based identify|nmod|assay identify|dobj|deficiency deficiency|compound|END_ENTITY	An antithrombin_III assay based on factor_Xa inhibition provides a more reliable test to identify congenital antithrombin_III deficiency than an assay based on thrombin inhibition .
8470046	0	thrombin	160,168	antithrombin_III	3,19	thrombin	antithrombin III	2147	462	Gene	Gene	inhibition|compound|START_ENTITY based|nmod|inhibition assay|acl|based identify|nmod|assay provides|advcl|identify provides|nsubj|assay assay|amod|END_ENTITY	An antithrombin_III assay based on factor_Xa inhibition provides a more reliable test to identify congenital antithrombin_III deficiency than an assay based on thrombin inhibition .
8470059	0	thrombin	103,111	antithrombin_III	12,28	thrombin	antithrombin III	2147	462	Gene	Gene	generation|compound|START_ENTITY quenching|dobj|generation ineffective|advcl|quenching ineffective|nsubj|levels levels|compound|END_ENTITY	Supranormal antithrombin_III levels induced by concentrate administration are ineffective in quenching thrombin generation in acute_promyelocytic_leukemia .
2844832	0	thrombin	69,77	bombesin	53,61	thrombin	bombesin	2147	2922	Gene	Gene	response|nmod|START_ENTITY response|nmod|END_ENTITY	Differential response of normal human fibroblasts to bombesin versus thrombin .
11755956	0	thrombin	33,41	bradykinin	71,81	thrombin	bradykinin	2147	3827	Gene	Gene	START_ENTITY|nmod|analogs analogs|compound|END_ENTITY	Developing peptide inhibitors to thrombin activation of platelets from bradykinin analogs .
3040721	0	thrombin	76,84	c-sis	57,62	thrombin	c-sis	2147	5155	Gene	Gene	induction|nmod|START_ENTITY induction|nsubj|Agents Agents|dep|block block|dobj|END_ENTITY	Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta .
8621696	0	thrombin	20,28	c-sis	99,104	thrombin	c-sis	2147	5155	Gene	Gene	element|compound|START_ENTITY Identification|nmod|element Identification|nmod|promoter promoter|appos|END_ENTITY	Identification of a thrombin response element in the human platelet-derived_growth_factor_B-chain -LRB- c-sis -RRB- promoter .
8400294	0	thrombin	123,131	cathepsin_G	29,40	thrombin	cathepsin G	2147	1511	Gene	Gene	comparison|nmod|START_ENTITY Effects|dep|comparison Effects|nmod|END_ENTITY	Effects of leukocyte-derived cathepsin_G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes : a comparison with thrombin .
11798640	0	thrombin	91,99	endothelin-1	26,38	thrombin	endothelin-1	2147	1906	Gene	Gene	stimulated|nmod|START_ENTITY proliferation|acl|stimulated END_ENTITY|nmod|proliferation	-LSB- The mediation effects of endothelin-1 on human mesangial cell proliferation stimulated by thrombin -RSB- .
1472106	0	thrombin	22,30	endothelin-1	34,46	thrombin	endothelin-1	280685(Tax:9913)	281137(Tax:9913)	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|nmod|biosynthesis biosynthesis|amod|END_ENTITY	Cellular mechanism of thrombin on endothelin-1 biosynthesis and release in bovine endothelial cell .
1571476	0	thrombin	78,86	endothelin-1	21,33	thrombin	endothelin-1	2147	1906	Gene	Gene	stimulation|nmod|START_ENTITY Release|nmod|stimulation Release|dobj|mechanism mechanism|nmod|endothelin-1 endothelin-1|amod|END_ENTITY	Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells .
1571476	0	thrombin	78,86	endothelin-1	42,54	thrombin	endothelin-1	2147	1906	Gene	Gene	stimulation|nmod|START_ENTITY Release|nmod|stimulation Release|dobj|mechanism mechanism|nmod|END_ENTITY	Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells .
16222888	0	thrombin	69,77	endothelin-1	31,43	thrombin	endothelin-1	2147	1906	Gene	Gene	stimulated|nmod|START_ENTITY production|acl|stimulated production|amod|END_ENTITY	Electromagnetic_fields inhibit endothelin-1 production stimulated by thrombin in endothelial cells .
1725395	0	thrombin	22,30	endothelin-1	34,46	thrombin	endothelin-1	29251(Tax:10116)	24323(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|production production|amod|END_ENTITY	Stimulatory effect of thrombin on endothelin-1 production in isolated glomeruli and cultured mesangial cells of rats .
8156101	0	thrombin	42,50	endothelin-1	15,27	thrombin	endothelin-1	2147	1906	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Stimulation of endothelin-1 production by thrombin , but lack of interference by high ambient glucose in vitro .
10929041	0	thrombin	120,128	extracellular_signal-related_kinase_2	151,188	thrombin	extracellular signal-related kinase 2	2147	5594	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|activation activation|nmod|END_ENTITY	Porcine von_Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase -LRB- JNK/SAPK -RRB- whereas only thrombin induces activation of extracellular_signal-related_kinase_2 -LRB- ERK2 -RRB- in human platelets .
8631976	0	thrombin	19,27	factor_XI	53,62	thrombin	factor XI	2147	2160	Gene	Gene	START_ENTITY|nmod|domain domain|nmod|END_ENTITY	A binding site for thrombin in the apple 1 domain of factor_XI .
10089309	0	thrombin	14,22	factor_Xa	82,91	thrombin	factor Xa	2147	2159	Gene	Gene	Structures|nmod|START_ENTITY retro-inhibited|nsubj|Structures retro-inhibited|advcl|relate relate|nmod|END_ENTITY	Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor_Xa binding .
15882894	0	thrombin	59,67	factor_Xa	27,36	thrombin	factor Xa	2147	2159	Gene	Gene	generation|compound|START_ENTITY DX-9065a|nmod|generation inhibitor|xcomp|DX-9065a inhibitor|nsubj|Effect Effect|nmod|END_ENTITY	Effect of the novel direct factor_Xa inhibitor DX-9065a on thrombin generation and inhibition among patients with stable atherosclerotic_coronary_artery_disease .
17388799	0	thrombin	23,31	factor_Xa	104,113	thrombin	factor Xa	2147	2159	Gene	Gene	generation|compound|START_ENTITY inhibition|nmod|generation activation|nmod|inhibition activation|nmod|rivaroxaban rivaroxaban|compound|END_ENTITY	In vitro inhibition of thrombin generation , after tissue factor pathway activation , by the oral , direct factor_Xa inhibitor rivaroxaban .
17462889	0	thrombin	77,85	factor_Xa	34,43	thrombin	factor Xa	2147	2159	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|nmod|inhibitors inhibitors|nsubj|END_ENTITY	From selective substrate analogue factor_Xa inhibitors to dual inhibitors of thrombin and factor_Xa .
19561526	0	thrombin	76,84	factor_Xa	55,64	thrombin	factor Xa	2147	2159	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|compound|END_ENTITY	Novel anticoagulants in clinical development : focus on factor_Xa and direct thrombin inhibitors .
2459011	0	thrombin	37,45	factor_Xa	4,13	thrombin	factor Xa	2147	2159	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|inhibitors inhibitors|compound|END_ENTITY	Are factor_Xa inhibitors superior to thrombin inhibitors in anticoagulation ?
25457584	0	thrombin	140,148	factor_Xa	164,173	thrombin	factor Xa	2147	2159	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|nmod|inhibitors inhibitors|compound|END_ENTITY	A meta-analysis of phase III randomized controlled trials with novel oral anticoagulants in atrial_fibrillation : Comparisons between direct thrombin inhibitors vs. factor_Xa inhibitors and different dosing regimens .
2968979	0	thrombin	36,44	factor_Xa	136,145	thrombin	factor Xa	2147	2159	Gene	Gene	complex|amod|START_ENTITY structure|nmod|complex explains|nsubj|structure explains|dobj|mechanisms mechanisms|nmod|inhibition inhibition|nmod|thrombin thrombin|appos|END_ENTITY	A predicted tertiary structure of a thrombin inhibitor-trypsin complex explains the mechanisms of the selective inhibition of thrombin , factor_Xa , plasmin , and trypsin .
7641380	0	thrombin	8,16	factor_Xa	31,40	thrombin	factor Xa	2147	2159	Gene	Gene	Role|nmod|START_ENTITY compared|nsubj|Role compared|nmod|END_ENTITY	Role of thrombin compared with factor_Xa in the procoagulant activity of whole blood_clots .
8470046	0	thrombin	160,168	factor_Xa	35,44	thrombin	factor Xa	2147	2159	Gene	Gene	inhibition|compound|START_ENTITY based|nmod|inhibition assay|acl|based identify|nmod|assay provides|advcl|identify provides|nsubj|assay assay|nmod|inhibition inhibition|compound|END_ENTITY	An antithrombin_III assay based on factor_Xa inhibition provides a more reliable test to identify congenital antithrombin_III deficiency than an assay based on thrombin inhibition .
9364987	0	thrombin	14,22	factor_Xa	61,70	thrombin	factor Xa	2147	2159	Gene	Gene	generation|compound|START_ENTITY Inhibition|nmod|generation Inhibition|nmod|inhibitors inhibitors|nmod|END_ENTITY	Inhibition of thrombin generation in plasma by inhibitors of factor_Xa .
17873238	0	thrombin	80,88	factor_xa	28,37	thrombin	factor xa	2147	2159	Gene	Gene	generation|compound|START_ENTITY rivaroxaban|nmod|generation rivaroxaban|nsubj|Effects Effects|nmod|inhibitor inhibitor|compound|END_ENTITY	Effects of the oral , direct factor_xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity .
10637	0	thrombin	62,70	fibrinogen	14,24	thrombin	fibrinogen	2147	2244	Gene	Gene	absence|nmod|START_ENTITY Reactivity|nmod|absence Reactivity|nmod|sites sites|amod|END_ENTITY	Reactivity of fibrinogen crosslinking sites in the absence of thrombin .
10837485	0	thrombin	43,51	fibrinogen	12,22	thrombin	fibrinogen	2147	2244	Gene	Gene	specificity|compound|START_ENTITY dictates|nsubj|specificity reveal|ccomp|dictates reveal|nsubj|studies studies|compound|END_ENTITY	Recombinant fibrinogen studies reveal that thrombin specificity dictates order of fibrinopeptide release .
10891092	0	thrombin	29,37	fibrinogen	50,60	thrombin	fibrinogen	2147	2244	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Mutation of W215 compromises thrombin cleavage of fibrinogen , but not of PAR-1 or protein C. W215 is a highly conserved residue that shapes the S3 and S4 specificity sites of thrombin and participates in an edge-to-face interaction with residue F8 of the fibrinogen Aalpha chain .
11460501	0	thrombin	29,37	fibrinogen	50,60	thrombin	fibrinogen	2147	2244	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Mutation of W215 compromises thrombin cleavage of fibrinogen , but not of PAR1 or protein C. W215 is a highly conserved residue that shapes the S3 and S4 specificity sites of thrombin .
1149268	0	thrombin	50,58	fibrinogen	30,40	thrombin	fibrinogen	2147	2244	Gene	Gene	measurement|amod|START_ENTITY based|nmod|measurement based|nsubj|method method|nmod|END_ENTITY	An improved method for plasma fibrinogen based on thrombin time measurement .
1587268	0	thrombin	19,27	fibrinogen	33,43	thrombin	fibrinogen	2147	2244	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of thrombin with fibrinogen .
1621283	0	thrombin	96,104	fibrinogen	19,29	thrombin	fibrinogen	2147	2244	Gene	Gene	stimulated|nmod|START_ENTITY Role|acl|stimulated Role|nmod|exogenous exogenous|acl|END_ENTITY	-LSB- Role of exogenous fibrinogen in the processes of degranulation of thrombocytes stimulated with thrombin .
1634610	0	thrombin	63,71	fibrinogen	19,29	thrombin	fibrinogen	2147	2244	Gene	Gene	associated|nmod|START_ENTITY associated|nsubj|basis basis|nmod|Naples Naples|compound|END_ENTITY	Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia .
16962697	0	thrombin	21,29	fibrinogen	46,56	thrombin	fibrinogen	2147	2244	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|peptide peptide|nmod:poss|gamma gamma|amod|END_ENTITY	Crystal structure of thrombin in complex with fibrinogen gamma ' peptide .
1706295	0	thrombin	15,23	fibrinogen	66,76	thrombin	fibrinogen	2147	2244	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|presence presence|nmod|END_ENTITY	Interaction of thrombin with endothelial cells in the presence of fibrinogen and alpha_2-macroglobulin .
19513421	0	thrombin	97,105	fibrinogen	26,36	thrombin	fibrinogen	2147	2244	Gene	Gene	effect|nmod|START_ENTITY inhibits|nmod|effect inhibits|nsubj|modification modification|nmod|END_ENTITY	Oxidative modification of fibrinogen inhibits its transformation into fibrin under the effect of thrombin .
2053103	0	thrombin	64,72	fibrinogen	22,32	thrombin	fibrinogen	2147	2244	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|analog analog|nmod|27-50 27-50|amod|alpha alpha|dep|END_ENTITY	A synthetic analog of fibrinogen alpha 27-50 is an inhibitor of thrombin .
21086376	0	thrombin	35,43	fibrinogen	14,24	thrombin	fibrinogen	2147	2244	Gene	Gene	START_ENTITY|dep|Use Use|nmod|END_ENTITY	-LSB- Use of human fibrinogen and human thrombin for urethral reconstructive surgery . -RSB-
22439748	0	thrombin	49,57	fibrinogen	65,75	thrombin	fibrinogen	2147	2244	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|chain chain|nmod:poss|y y|compound|END_ENTITY	Role of electrostatic interactions in binding of thrombin to the fibrinogen y ' chain .
23360261	0	thrombin	199,207	fibrinogen	2,12	thrombin	fibrinogen	2147	2244	Gene	Gene	induced|nmod|START_ENTITY fibrinolysis|acl|induced reverse|nmod|fibrinolysis concentrate|ccomp|reverse concentrate|nsubj|END_ENTITY	A fibrinogen concentrate Haemocomplettan -LRB- Riastap -RRB- or a Factor XIII concentrate Fibrogammin combined with a mini dose of tranexamic_acid can reverse the fibrin instability to fibrinolysis induced by thrombin - or FXa-inhibitor .
25239831	0	thrombin	61,69	fibrinogen	36,46	thrombin	fibrinogen	2147	2244	Gene	Gene	affect|nmod|START_ENTITY affect|dobj|hydrolysis hydrolysis|compound|END_ENTITY	How does association process affect fibrinogen hydrolysis by thrombin ?
2642712	0	thrombin	71,79	fibrinogen	16,26	thrombin	fibrinogen	2147	2244	Gene	Gene	substrate|compound|START_ENTITY Expression|dep|substrate Expression|nmod|peptide peptide|amod|END_ENTITY	Expression of a fibrinogen fusion peptide in Escherichia_coli : a model thrombin substrate for structure/function analysis .
3053360	0	thrombin	116,124	fibrinogen	24,34	thrombin	fibrinogen	2147	2244	Gene	Gene	presence|nmod|START_ENTITY derived|nmod|presence derived|nsubj|interaction interaction|nmod|peptides peptides|compound|END_ENTITY	The interaction between fibrinogen and 3H-L-arginine cationic peptides derived from fibrosarcoma in the presence of thrombin .
3738860	0	thrombin	44,52	fibrinogen	8,18	thrombin	fibrinogen	2147	2244	Gene	Gene	generated|nmod|START_ENTITY derivatives|acl|generated derivatives|compound|END_ENTITY	Soluble fibrinogen derivatives generated by thrombin : affinity for elastin .
3750276	0	thrombin	28,36	fibrinogen	96,106	thrombin	fibrinogen	2147	2244	Gene	Gene	platelets|amod|START_ENTITY Adhesion|nmod|platelets Adhesion|dep|evaluation evaluation|nmod|END_ENTITY	Adhesion and aggregation of thrombin prestimulated human platelets : evaluation of surface-bound fibrinogen and surface-bound albumin .
3886645	1	thrombin	94,102	fibrinogen	78,88	thrombin	fibrinogen	2147	2244	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|interaction interaction|nmod|END_ENTITY	Effect on the interaction of fibrinogen with thrombin from diethyl_pyrocarbonate-modified prothrombin .
3983914	0	thrombin	75,83	fibrinogen	32,42	thrombin	fibrinogen	2147	2244	Gene	Gene	enhanced|dep|START_ENTITY thiol|acl|enhanced gelation|dep|thiol gelation|nmod|END_ENTITY	FXIII induced gelation of human fibrinogen -- an alternative thiol enhanced , thrombin independent pathway .
4074798	0	thrombin	93,101	fibrinogen	16,26	thrombin	fibrinogen	2147	2244	Gene	Gene	-RSB-|compound|START_ENTITY differing|nmod|-RSB- Interaction|acl|differing Interaction|nmod|END_ENTITY	-LSB- Interaction of fibrinogen with two forms of fibrin differing in the degree of activation by thrombin -RSB- .
4750457	0	thrombin	30,38	fibrinogen	49,59	thrombin	fibrinogen	2147	2244	Gene	Gene	estimating|dobj|START_ENTITY method|acl|estimating clottable|nsubj|method clottable|dobj|END_ENTITY	A batch method for estimating thrombin clottable fibrinogen .
5014617	0	thrombin	100,108	fibrinogen	12,22	thrombin	fibrinogen	2147	2244	Gene	Gene	Increase|nmod|START_ENTITY Increase|nmod|antigen antigen|compound|END_ENTITY	Increase in fibrinogen and fibrin-related antigen in human serum due to in vitro lysis of fibrin by thrombin .
5862557	0	thrombin	109,117	fibrinogen	13,23	thrombin	fibrinogen	2147	2244	Gene	Gene	adenosine_diphosphate|appos|START_ENTITY induced|nmod|adenosine_diphosphate induced|nsubj|Influence Influence|nmod|END_ENTITY	Influence of fibrinogen on the aggregation of washed human blood platelets induced by adenosine_diphosphate , thrombin , collagen , and adrenaline .
6417869	0	thrombin	59,67	fibrinogen	11,21	thrombin	fibrinogen	2147	2244	Gene	Gene	Sources|nmod|START_ENTITY Sources|nmod|END_ENTITY	Sources of fibrinogen for coagulum pyelolithotomy , without thrombin .
6444358	0	thrombin	35,43	fibrinogen	67,77	thrombin	fibrinogen	2147	2244	Gene	Gene	converted|nmod|START_ENTITY converted|nmod|END_ENTITY	Localizaton of fibrin converted by thrombin from released platelet fibrinogen .
6453297	0	thrombin	55,63	fibrinogen	28,38	thrombin	fibrinogen	2147	2244	Gene	Gene	chain|nmod|START_ENTITY chain|nsubj|proteolysis proteolysis|nmod|beta beta|amod|END_ENTITY	Relative proteolysis of the fibrinogen B beta chain by thrombin and plasmin as a determinant of thrombosis .
6626500	0	thrombin	23,31	fibrinogen	35,45	thrombin	fibrinogen	2147	2244	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of thrombin on fibrinogen .
6783348	1	thrombin	110,118	fibrinogen	129,139	thrombin	fibrinogen	2147	2244	Gene	Gene	technique|nmod|START_ENTITY comparison|nmod|technique clottable|nsubj|comparison clottable|dobj|END_ENTITY	A comparison of the technique against thrombin clottable fibrinogen with spectrophotometry and radial immuno-diffusion .
6800197	0	thrombin	46,54	fibrinogen	76,86	thrombin	fibrinogen	2147	2244	Gene	Gene	assay|compound|START_ENTITY conditions|nmod|assay study|nmod|conditions study|nmod|END_ENTITY	A study of the conditions and accuracy of the thrombin time assay of plasma fibrinogen .
7117668	0	thrombin	14,22	fibrinogen	124,134	thrombin	fibrinogen	2147	2244	Gene	Gene	cleavage|compound|START_ENTITY Inhibition|nmod|cleavage Inhibition|dep|interaction interaction|nmod|residues residues|nmod|END_ENTITY	Inhibition of thrombin cleavage of fibrinogen by polyestradiol_phosphate ; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage .
7117668	0	thrombin	14,22	fibrinogen	35,45	thrombin	fibrinogen	2147	2244	Gene	Gene	cleavage|compound|START_ENTITY cleavage|nmod|END_ENTITY	Inhibition of thrombin cleavage of fibrinogen by polyestradiol_phosphate ; interaction with the crucial arginine residues in fibrinogen required for enzymic cleavage .
7150549	0	thrombin	23,31	fibrinogen	35,45	thrombin	fibrinogen	2147	2244	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of thrombin on fibrinogen .
7190836	0	thrombin	23,31	fibrinogen	35,45	thrombin	fibrinogen	2147	2244	Gene	Gene	Mechanism|nmod|START_ENTITY Mechanism|nmod|END_ENTITY	Mechanism of action of thrombin on fibrinogen .
7900079	0	thrombin	133,141	fibrinogen	17,27	thrombin	fibrinogen	2147	2244	Gene	Gene	system|nmod|START_ENTITY activation|nmod|system evidence|nmod|activation influence|dep|evidence influence|nmod|END_ENTITY	The influence of fibrinogen and fibrin on thrombin generation -- evidence for feedback activation of the clotting system by clot bound thrombin .
7900079	0	thrombin	42,50	fibrinogen	17,27	thrombin	fibrinogen	2147	2244	Gene	Gene	generation|compound|START_ENTITY influence|nmod|generation influence|nmod|END_ENTITY	The influence of fibrinogen and fibrin on thrombin generation -- evidence for feedback activation of the clotting system by clot bound thrombin .
7967434	0	thrombin	10,18	fibrinogen	37,47	thrombin	fibrinogen	2147	2244	Gene	Gene	generation|compound|START_ENTITY generation|nmod|recovery recovery|compound|END_ENTITY	Increased thrombin generation during fibrinogen and platelet recovery as an explanation for hypercoagulability in children with L-asparaginase therapy for ALL or NHL : a preliminary report .
8091386	0	thrombin	40,48	fibrinogen	89,99	thrombin	fibrinogen	2147	2244	Gene	Gene	activation|compound|START_ENTITY marker|nmod|activation levels|nmod|marker levels|dep|insights insights|nmod|role role|nmod|END_ENTITY	Fibrinogen plasma levels as a marker of thrombin activation : new insights on the role of fibrinogen as a cardiovascular_risk factor .
8362369	0	thrombin	86,94	fibrinogen	61,71	thrombin	fibrinogen	2147	2244	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|nmod|E E|amod|END_ENTITY	Comparison of the sequence of fibrinopeptide A cleavage from fibrinogen fragment E by thrombin , atroxin , or batroxobin .
8364489	0	thrombin	85,93	fibrinogen	15,25	thrombin	fibrinogen	2147	2244	Gene	Gene	conversion|nmod|START_ENTITY sialic_acid|nmod|conversion effects|nmod|sialic_acid Sialic_acid|dep|effects Sialic_acid|nmod|END_ENTITY	Sialic_acid in fibrinogen : effects of sialic_acid on fibrinogen-fibrin conversion by thrombin and properties of asialofibrin clot .
8652575	0	thrombin	91,99	fibrinogen	55,65	thrombin	fibrinogen	2147	2244	Gene	Gene	substrates|compound|START_ENTITY variants|nmod|substrates variants|amod|END_ENTITY	Strategy for recombinant multichain protein synthesis : fibrinogen B beta-chain variants as thrombin substrates .
8662661	0	thrombin	31,39	fibrinogen	54,64	thrombin	fibrinogen	2147	2244	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Transient intermediates in the thrombin activation of fibrinogen .
8703074	0	thrombin	73,81	fibrinogen	48,58	thrombin	fibrinogen	2147	2244	Gene	Gene	modulator|compound|START_ENTITY cleavage|nmod|modulator cleavage|nsubj|activation activation|nmod|END_ENTITY	Enhanced protein C activation and inhibition of fibrinogen cleavage by a thrombin modulator .
8865525	0	thrombin	20,28	fibrinogen	110,120	thrombin	fibrinogen	2147	2244	Gene	Gene	generation|compound|START_ENTITY reduces|dobj|generation reduces|advcl|influencing influencing|dobj|END_ENTITY	Gemfibrozil reduces thrombin generation in patients with combined_hyperlipidaemia , without influencing plasma fibrinogen , fibrin gel structure or coagulation_factor_VII .
89993	0	thrombin	14,22	fibrinogen	48,58	thrombin	fibrinogen	2147	2244	Gene	Gene	increased|nsubj|START_ENTITY increased|ccomp|count count|nsubj|aggregates aggregates|compound|END_ENTITY	Short heparin thrombin clotting time , increased fibrinogen and platelet aggregates count in coronary_disease : a probable hypercoagulable state .
9175247	0	thrombin	69,77	fibrinogen	44,54	thrombin	fibrinogen	2147	2244	Gene	Gene	related|xcomp|START_ENTITY related|nsubjpass|release release|nmod|END_ENTITY	Fibrinopeptide_A release from intraplatelet fibrinogen is related to thrombin platelet activation .
9242618	0	thrombin	53,61	fibrinogen	18,28	thrombin	fibrinogen	2147	2244	Gene	Gene	clotting|nmod|START_ENTITY loss|acl|clotting loss|nmod|END_ENTITY	Selective loss of fibrinogen clotting in a loop-less thrombin .
9401064	0	thrombin	14,22	fibrinogen	87,97	thrombin	fibrinogen	2147	2244	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|exchange exchange|nmod|END_ENTITY	The effect of thrombin on the dynamic exchange between intraplatelet and extraplatelet fibrinogen .
9753458	0	thrombin	87,95	fibrinogen	130,140	thrombin	fibrinogen	2147	2244	Gene	Gene	cleavage|compound|START_ENTITY fibrinopeptide|nmod|cleavage fibrinopeptide|nmod|END_ENTITY	Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen .
16113793	0	thrombin	54,62	glycoprotein_VI	78,93	thrombin	glycoprotein VI	2147	51206	Gene	Gene	generation|compound|START_ENTITY generation|nmod|END_ENTITY	Fibrillar type I collagens enhance platelet-dependent thrombin generation via glycoprotein_VI with direct support of alpha2beta1 but not alphaIIbbeta3 integrin .
3718412	0	thrombin	40,48	growth_hormone	52,66	thrombin	growth hormone	2147	2688	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Biochemistry of tumor cell thrombosis : thrombin as growth_hormone -RSB- .
10209287	0	thrombin	71,79	heparin_cofactor_II	23,42	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inhibition|compound|START_ENTITY stimulation|nmod|inhibition required|nmod|stimulation required|nsubj|residues residues|nmod|END_ENTITY	Amino_acid residues of heparin_cofactor_II required for stimulation of thrombin inhibition by sulphated polyanions .
10488098	0	thrombin	66,74	heparin_cofactor_II	91,110	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inactivation|compound|START_ENTITY catalysis|nmod|inactivation sulfate-mediated|dobj|catalysis sulfate-mediated|nmod|END_ENTITY	Comparison of heparin - and dermatan sulfate-mediated catalysis of thrombin inactivation by heparin_cofactor_II .
11051806	0	thrombin	78,86	heparin_cofactor_II	11,30	thrombin	heparin cofactor II	2147	3053	Gene	Gene	methods|compound|START_ENTITY measured|nmod|methods measured|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of heparin_cofactor_II on the antithrombin_III activities measured by thrombin methods or factor_Xa methods -- fundamental studies and clinical studies using the plasma of pregnant women -RSB- .
11068038	0	thrombin	31,39	heparin_cofactor_II	74,93	thrombin	heparin cofactor II	2147	3053	Gene	Gene	Effect|nmod|START_ENTITY aptamer|nsubj|Effect aptamer|nmod|END_ENTITY	Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin_cofactor_II and antithrombin .
11068038	0	thrombin	51,59	heparin_cofactor_II	74,93	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inhibition|compound|START_ENTITY aptamer|nmod|inhibition aptamer|nmod|END_ENTITY	Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin_cofactor_II and antithrombin .
12095635	0	thrombin	110,118	heparin_cofactor_II	49,68	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Contribution of basic residues of the A helix of heparin_cofactor_II to heparin - or dermatan sulfate-mediated thrombin inhibition .
14701814	0	thrombin	71,79	heparin_cofactor_II	83,102	thrombin	heparin cofactor II	2147	3053	Gene	Gene	pathway|nmod|START_ENTITY pathway|nmod|END_ENTITY	The preferred pathway of glycosaminoglycan-accelerated inactivation of thrombin by heparin_cofactor_II .
1646716	1	thrombin	102,110	heparin_cofactor_II	127,146	thrombin	heparin cofactor II	100009146(Tax:9986)	100009170(Tax:9986)	Gene	Gene	inactivation|compound|START_ENTITY effects|nmod|inactivation effects|nmod|END_ENTITY	Their glycosaminoglycan-dependent modulatory effects on thrombin inactivation by heparin_cofactor_II and antithrombin III .
16981704	0	thrombin	160,168	heparin_cofactor_II	68,87	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inhibition|compound|START_ENTITY rate|nmod|inhibition increases|dobj|rate increases|nsubj|fusion fusion|nmod|extension extension|nmod|END_ENTITY	The transferable tail : fusion of the N-terminal acidic extension of heparin_cofactor_II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition .
18000606	0	thrombin	186,194	heparin_cofactor_II	28,47	thrombin	heparin cofactor II	14061(Tax:10090)	15160(Tax:10090)	Gene	Gene	M358R|nmod|START_ENTITY reactivity|nmod|M358R increase|dobj|reactivity combine|xcomp|increase combine|nsubj|region region|nmod|END_ENTITY	The appended tail region of heparin_cofactor_II and additional reactive centre loop mutations combine to increase the reactivity and specificity of alpha1-proteinase inhibitor M358R for thrombin .
18383370	0	thrombin	30,38	heparin_cofactor_II	58,77	thrombin	heparin cofactor II	2147	3053	Gene	Gene	protects|dobj|START_ENTITY protects|nmod|inhibition inhibition|nmod|END_ENTITY	Beta2-glycoprotein_I protects thrombin from inhibition by heparin_cofactor_II : potentiation of this effect in the presence of anti-beta2-glycoprotein_I autoantibodies .
19046760	0	thrombin	13,21	heparin_cofactor_II	36,55	thrombin	heparin cofactor II	2147	3053	Gene	Gene	dermatan|compound|START_ENTITY dermatan|amod|inhibition inhibition|nmod|END_ENTITY	Mechanism of thrombin inhibition by heparin_cofactor_II and antithrombin in the presence of the ray -LRB- Raja radula -RRB- skin dermatan sulfate .
20053992	0	thrombin	44,52	heparin_cofactor_II	69,88	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inactivation|compound|START_ENTITY accelerates|dobj|inactivation accelerates|nmod|END_ENTITY	Sucrose_octasulfate selectively accelerates thrombin inactivation by heparin_cofactor_II .
2512688	0	thrombin	15,23	heparin_cofactor_II	29,48	thrombin	heparin cofactor II	2147	3053	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of thrombin with heparin_cofactor_II and antithrombin_III on prostacyclin production by cultured endothelial cells .
3401503	0	thrombin	71,79	heparin_cofactor_II	94,113	thrombin	heparin cofactor II	2147	3053	Gene	Gene	Studies|nmod|START_ENTITY Studies|acl|inhibition inhibition|nmod|END_ENTITY	Studies on the structural requirements of heparin for the catalysis of thrombin inhibition by heparin_cofactor_II .
3675584	0	thrombin	48,56	heparin_cofactor_II	60,79	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inhibition|nmod|START_ENTITY accelerate|dobj|inhibition accelerate|nmod|END_ENTITY	Carboxylate polyanions accelerate inhibition of thrombin by heparin_cofactor_II .
3691797	0	thrombin	122,130	heparin_cofactor_II	134,153	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inhibition|nmod|START_ENTITY essential|nmod|inhibition essential|nmod|END_ENTITY	Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin_cofactor_II .
3691797	0	thrombin	42,50	heparin_cofactor_II	134,153	thrombin	heparin cofactor II	2147	3053	Gene	Gene	sulfate|nmod|START_ENTITY Binding|nmod|sulfate essential|nsubj|Binding essential|nmod|END_ENTITY	Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin_cofactor_II .
7781777	0	thrombin	76,84	heparin_cofactor_II	24,43	thrombin	heparin cofactor II	100009146(Tax:9986)	100009170(Tax:9986)	Gene	Gene	serpin|compound|START_ENTITY size|nmod|serpin defining|dobj|size mutagenesis|parataxis|defining mutagenesis|nmod|END_ENTITY	Deletion mutagenesis of heparin_cofactor_II : defining the minimum size of a thrombin inhibiting serpin .
7974347	0	thrombin	73,81	heparin_cofactor_II	43,62	thrombin	heparin cofactor II	100009146(Tax:9986)	100009170(Tax:9986)	Gene	Gene	inhibitor|compound|START_ENTITY cloning|dep|inhibitor cloning|nmod|END_ENTITY	Molecular cloning and expression of rabbit heparin_cofactor_II : a plasma thrombin inhibitor highly conserved between species .
8792767	0	thrombin	69,77	heparin_cofactor_II	92,111	thrombin	heparin cofactor II	2147	3053	Gene	Gene	inhibition|compound|START_ENTITY accelerate|dobj|inhibition accelerate|nmod|END_ENTITY	Arterial smooth muscle cell heparan_sulfate proteoglycans accelerate thrombin inhibition by heparin_cofactor_II .
8995378	0	thrombin	45,53	heparin_cofactor_II	103,122	thrombin	heparin cofactor II	2147	3053	Gene	Gene	START_ENTITY|nmod|mutant mutant|nmod|END_ENTITY	Heparin promotes proteolytic inactivation by thrombin of a reactive site mutant -LRB- L444R -RRB- of recombinant heparin_cofactor_II .
9068899	0	thrombin	13,21	heparin_cofactor_II	36,55	thrombin	heparin cofactor II	2147	3053	Gene	Gene	Mechanism|nmod|START_ENTITY inhibition|nsubj|Mechanism inhibition|nmod|END_ENTITY	Mechanism of thrombin inhibition by heparin_cofactor_II in the presence of dermatan sulphates , native or oversulphated , and a heparin-like dextran derivative .
9623718	0	thrombin	60,68	heparin_cofactor_II	31,50	thrombin	heparin cofactor II	29251(Tax:10116)	79224(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	Effects of dermatan_sulfate , a heparin_cofactor_II mediated thrombin inhibitor , on the endotoxin-induced disseminated_intravascular_coagulation model in the rat : comparison with low-molecular weight heparin , nafamostat_mesilate and argathroban .
7855791	0	thrombin	44,52	high_molecular_weight_kininogen	72,103	thrombin	high molecular weight kininogen	2147	3827	Gene	Gene	START_ENTITY|nmod|presence presence|nmod|END_ENTITY	Surface independent factor XI activation by thrombin in the presence of high_molecular_weight_kininogen .
15998775	0	thrombin	21,29	interleukin-11	61,75	thrombin	interleukin-11	2147	3589	Gene	Gene	production|amod|START_ENTITY production|amod|END_ENTITY	Progestin suppresses thrombin - and interleukin-1beta-induced interleukin-11 production in term decidual cells : implications for preterm_delivery .
18206982	0	thrombin	8,16	interleukin-5	20,33	thrombin	interleukin-5	2147	3567	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of thrombin in interleukin-5 expression from basophils .
2266131	0	thrombin	39,47	leuserpin-2	27,38	thrombin	leuserpin-2	2147	3053	Gene	Gene	interaction|compound|START_ENTITY END_ENTITY|dep|interaction	Glycosaminoglycan-mediated leuserpin-2 / thrombin interaction .
12900518	1	thrombin	161,169	mast_cell_protease_4	137,157	thrombin	mast cell protease 4	14061(Tax:10090)	17227(Tax:10090)	Gene	Gene	regulation|amod|START_ENTITY role|nmod|regulation role|nmod|END_ENTITY	A role for mouse mast_cell_protease_4 in thrombin regulation and fibronectin turnover .
22492089	0	thrombin	22,30	matrix_metalloproteinase-10	62,89	thrombin	matrix metalloproteinase-10	2147	4319	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|amod|END_ENTITY	Synergistic effect of thrombin and CD40_ligand on endothelial matrix_metalloproteinase-10 expression and microparticle generation in vitro and in vivo .
8003007	0	thrombin	65,73	microtubule_associated_protein_tau	27,61	thrombin	microtubule associated protein tau	2147	4137	Gene	Gene	degradation|nmod|START_ENTITY degradation|nmod|END_ENTITY	Proteolytic degradation of microtubule_associated_protein_tau by thrombin .
22687405	0	thrombin	194,202	monocyte_chemoattractant_protein-1	107,141	thrombin	monocyte chemoattractant protein-1	29251(Tax:10116)	24770(Tax:10116)	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|increase increase|nmod|stimulated stimulated|amod|END_ENTITY	Mizoribine suppresses proliferation of rat glomerular epithelial cells in culture and inhibits increase of monocyte_chemoattractant_protein-1 and macrophage_inflammatory_protein-2 stimulated by thrombin .
8632154	0	thrombin	36,44	nerve_growth_factor	62,81	thrombin	nerve growth factor	2147	4803	Gene	Gene	secretion|amod|START_ENTITY secretion|compound|END_ENTITY	Transduction mechanisms involved in thrombin receptor-induced nerve_growth_factor secretion and cell division in primary cultures of astrocytes .
8428900	0	thrombin	47,55	p72syk	24,30	thrombin	p72syk	2147	6850	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2 + mobilization in platelets .
1309426	0	thrombin	83,91	plasminogen_activator_inhibitor_type-1	25,63	thrombin	plasminogen activator inhibitor type-1	2147	5054	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|cells cells|amod|END_ENTITY	Synergistic induction of plasminogen_activator_inhibitor_type-1 in HEP G2 cells by thrombin and transforming_growth_factor-beta .
8621696	0	thrombin	20,28	platelet-derived_growth_factor_B-chain	59,97	thrombin	platelet-derived growth factor B-chain	2147	5155	Gene	Gene	element|compound|START_ENTITY Identification|nmod|element Identification|nmod|promoter promoter|amod|END_ENTITY	Identification of a thrombin response element in the human platelet-derived_growth_factor_B-chain -LRB- c-sis -RRB- promoter .
1329921	0	thrombin	14,22	platelet_factor_4	116,133	thrombin	platelet factor 4	2147	5196	Gene	Gene	generation|compound|START_ENTITY Inhibition|nmod|generation heparins|nsubj|Inhibition heparins|nmod|absence absence|nmod|END_ENTITY	Inhibition of thrombin generation by heparin and low molecular weight -LRB- LMW -RRB- heparins in the absence and presence of platelet_factor_4 -LRB- PF4 -RRB- .
15845904	0	thrombin	22,30	protease-activated_receptor-1	102,131	thrombin	protease-activated receptor-1	2147	2149	Gene	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|advcl|END_ENTITY	Synergistic effect of thrombin on collagen-induced platelet_procoagulant activity is mediated through protease-activated_receptor-1 .
10669659	0	thrombin	23,31	protease-activated_receptor_1	42,71	thrombin	protease-activated receptor 1	2147	2149	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Protective effect of a thrombin receptor -LRB- protease-activated_receptor_1 -RRB- gene polymorphism toward venous thromboembolism .
10780327	0	thrombin	123,131	protease-activated_receptor_1	92,121	thrombin	protease-activated receptor 1	2147	2149	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	Identification of a novel 33-kDa Ser/Thr kinase that phosphorylates the cytoplasmic tail of protease-activated_receptor_1 -LRB- thrombin receptor -RRB- in human platelets .
23204166	0	thrombin	108,116	protease-activated_receptor_1	131,160	thrombin	protease-activated receptor 1	2147	2149	Gene	Gene	activation|compound|START_ENTITY activation|nmod|END_ENTITY	Enhanced effector function of CD8 -LRB- + -RRB- T cells from healthy controls and HIV-infected patients occurs through thrombin activation of protease-activated_receptor_1 .
10365287	0	thrombin	35,43	thrombin	81,89	thrombin	thrombin	2147	2147	Gene	Gene	START_ENTITY|nmod|generation generation|compound|END_ENTITY	The effect of a low molecular mass thrombin inhibitor , inogatran , and heparin on thrombin generation and fibrin turnover in patients with unstable coronary_artery_disease .
10365287	0	thrombin	81,89	thrombin	35,43	thrombin	thrombin	2147	2147	Gene	Gene	generation|compound|START_ENTITY END_ENTITY|nmod|generation	The effect of a low molecular mass thrombin inhibitor , inogatran , and heparin on thrombin generation and fibrin turnover in patients with unstable coronary_artery_disease .
17595115	0	thrombin	15,23	thrombin	50,58	thrombin	thrombin	2147	2147	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|site site|compound|END_ENTITY	Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site .
17595115	0	thrombin	50,58	thrombin	15,23	thrombin	thrombin	2147	2147	Gene	Gene	site|compound|START_ENTITY Interaction|nmod|site Interaction|nmod|END_ENTITY	Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site .
18440754	0	thrombin	28,36	thrombin	47,55	thrombin	thrombin	280685(Tax:9913)	280685(Tax:9913)	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures .
18440754	0	thrombin	47,55	thrombin	28,36	thrombin	thrombin	280685(Tax:9913)	280685(Tax:9913)	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures .
7833057	0	thrombin	71,79	thrombin	93,101	thrombin	thrombin	2147	2147	Gene	Gene	START_ENTITY|nmod|receptor receptor|compound|END_ENTITY	The anion-binding exosite is critical for the high affinity binding of thrombin to the human thrombin receptor .
7833057	0	thrombin	93,101	thrombin	71,79	thrombin	thrombin	2147	2147	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|nmod|receptor	The anion-binding exosite is critical for the high affinity binding of thrombin to the human thrombin receptor .
16772741	0	thrombin	13,21	thrombin-activatable_fibrinolysis_inhibitor	68,111	thrombin	thrombin-activatable fibrinolysis inhibitor	2147	1361	Gene	Gene	formation|amod|START_ENTITY formation|nmod|END_ENTITY	Evolution of thrombin formation and fibrinolysis markers , including thrombin-activatable_fibrinolysis_inhibitor , during severe meningococcemia .
8756541	0	thrombin	71,79	thrombin_receptor	27,44	thrombin	thrombin receptor	29251(Tax:10116)	25439(Tax:10116)	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Rat uterine stromal cells : thrombin_receptor and growth stimulation by thrombin .
11013045	0	thrombin	89,97	thrombomodulin	12,26	thrombin	thrombomodulin	2147	7056	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Recombinant thrombomodulin inhibits arterial smooth muscle cell proliferation induced by thrombin .
12068020	0	thrombin	4,12	thrombomodulin	33,47	thrombin	thrombomodulin	2147	7056	Gene	Gene	epitope|compound|START_ENTITY epitope|acl|recognizing recognizing|dobj|END_ENTITY	The thrombin epitope recognizing thrombomodulin is a highly cooperative hot spot in exosite I .
1317850	0	thrombin	102,110	thrombomodulin	50,64	thrombin	thrombomodulin	2147	7056	Gene	Gene	exosite|nmod|START_ENTITY factor-like|nmod|exosite factor-like|dobj|domains domains|nmod|bind bind|compound|END_ENTITY	The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity .
15307903	0	thrombin	108,116	thrombomodulin	39,53	thrombin	thrombomodulin	29251(Tax:10116)	83580(Tax:10116)	Gene	Gene	implicates|dobj|START_ENTITY implicates|nsubj|effects effects|nmod|END_ENTITY	Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal_cord_injury implicates thrombin signaling .
16376423	0	thrombin	91,99	thrombomodulin	34,48	thrombin	thrombomodulin	2147	7056	Gene	Gene	generation|amod|START_ENTITY inhibit|dobj|generation inhibit|nsubj|films films|acl|containing containing|dobj|END_ENTITY	Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model .
1660464	0	thrombin	19,27	thrombomodulin	55,69	thrombin	thrombomodulin	2147	7056	Gene	Gene	site|nmod|START_ENTITY altered|nsubjpass|site altered|nmod|END_ENTITY	The active site of thrombin is altered upon binding to thrombomodulin .
1678522	0	thrombin	31,39	thrombomodulin	79,93	thrombin	thrombomodulin	2147	7056	Gene	Gene	substitution|nmod|START_ENTITY mimics|nsubj|substitution mimics|dobj|switch switch|acl|induced induced|nmod|END_ENTITY	Glu-192 -- Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin .
18444940	0	thrombin	31,39	thrombomodulin	4,18	thrombin	thrombomodulin	2147	7056	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI .
1964460	0	thrombin	81,89	thrombomodulin	32,46	thrombin	thrombomodulin	2147	7056	Gene	Gene	sites|nmod|START_ENTITY recognize|iobj|sites antibodies|acl:relcl|recognize antibodies|nmod|END_ENTITY	Monoclonal antibodies for human thrombomodulin which recognize binding sites for thrombin and protein C. Monoclonal antibodies for human thrombomodulin , a cofactor for thrombin-catalyzed activation of protein C , were prepared and their epitopes characterized .
19656282	0	thrombin	53,61	thrombomodulin	19,33	thrombin	thrombomodulin	2147	7056	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|activation activation|compound|END_ENTITY	Molecular basis of thrombomodulin activation of slow thrombin .
21130429	0	thrombin	10,18	thrombomodulin	58,72	thrombin	thrombomodulin	2147	7056	Gene	Gene	generation|compound|START_ENTITY measured|nsubj|generation measured|nmod|presence presence|nmod|END_ENTITY	Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy_loss .
2154059	0	thrombin	58,66	thrombomodulin	20,34	thrombin	thrombomodulin	2147	7056	Gene	Gene	inactivation|nmod|START_ENTITY effect|nmod|inactivation effect|nmod|END_ENTITY	The effect of human thrombomodulin on the inactivation of thrombin by human antithrombin_III .
2161655	0	thrombin	10,18	thrombomodulin	44,58	thrombin	thrombomodulin	2147	7056	Gene	Gene	affinity|compound|START_ENTITY affinity|nmod|END_ENTITY	Decreased thrombin affinity of cell-surface thrombomodulin following treatment of cultured endothelial cells with beta-D-xyloside .
25193406	0	thrombin	159,167	thrombomodulin	96,110	thrombin	thrombomodulin	2147	7056	Gene	Gene	generation|compound|START_ENTITY increase|nmod|generation unrelated|nmod|increase unrelated|nsubj|effect effect|nmod|dabigatran dabigatran|nmod|presence presence|nmod|END_ENTITY	The paradoxical antifibrinolytic effect of dabigatran and argatroban in the presence of soluble thrombomodulin is unrelated to protein_C-dependent increase of thrombin generation .
2538465	0	thrombin	102,110	thrombomodulin	70,84	thrombin	thrombomodulin	2147	7056	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|domain domain|acl|composed composed|nmod|structures structures|nmod|END_ENTITY	A domain composed of epidermal growth factor-like structures of human thrombomodulin is essential for thrombin binding and for protein C activation .
2829375	0	thrombin	59,67	thrombomodulin	21,35	thrombin	thrombomodulin	2147	7056	Gene	Gene	inactivation|nmod|START_ENTITY END_ENTITY|nmod|inactivation	The effects of human thrombomodulin on the inactivation of thrombin by its serum inhibitors .
2847349	0	thrombin	22,30	thrombomodulin	42,56	thrombin	thrombomodulin	2147	7056	Gene	Gene	Modification|nmod|START_ENTITY Modification|dep|effect effect|nmod|END_ENTITY	Modification of human thrombin : effect on thrombomodulin binding .
2848597	0	thrombin	38,46	thrombomodulin	11,25	thrombin	thrombomodulin	100009146(Tax:9986)	100008887(Tax:9986)	Gene	Gene	functions|compound|START_ENTITY END_ENTITY|nmod|functions	-LSB- Effect of thrombomodulin on specific thrombin functions : fibrinogen coagulation and thrombocyte aggregation -RSB- .
2984256	0	thrombin	83,91	thrombomodulin	6,20	thrombin	thrombomodulin	2147	7056	Gene	Gene	activity|nmod|START_ENTITY inhibitor|nmod|activity inhibitor|nsubj|END_ENTITY	Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin .
3005304	0	thrombin	65,73	thrombomodulin	21,35	thrombin	thrombomodulin	280685(Tax:9913)	281529(Tax:9913)	Gene	Gene	specificity|nmod|START_ENTITY effect|nmod|specificity effect|nmod|END_ENTITY	The effect of bovine thrombomodulin on the specificity of bovine thrombin .
3028582	0	thrombin	54,62	thrombomodulin	127,141	thrombin	thrombomodulin	100009146(Tax:9986)	100008887(Tax:9986)	Gene	Gene	inhibition|nmod|START_ENTITY thrombomodulin|nmod|inhibition Effect|nmod|thrombomodulin Effect|dep|role role|nmod|domain domain|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of rabbit thrombomodulin on the inhibition of thrombin by the antithrombin-heparin complex : role of the acid domain of thrombomodulin -RSB- .
3028582	0	thrombin	54,62	thrombomodulin	18,32	thrombin	thrombomodulin	100009146(Tax:9986)	100008887(Tax:9986)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	-LSB- Effect of rabbit thrombomodulin on the inhibition of thrombin by the antithrombin-heparin complex : role of the acid domain of thrombomodulin -RSB- .
7947765	0	thrombin	88,96	thrombomodulin	58,72	thrombin	thrombomodulin	2147	7056	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubj|Structure Structure|nmod|nonadecapeptide nonadecapeptide|nmod|domain domain|nmod|END_ENTITY	Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin .
8259542	0	thrombin	75,83	thrombomodulin	116,130	thrombin	thrombomodulin	2147	7056	Gene	Gene	generation|compound|START_ENTITY inhibition|nmod|generation amplifies|dobj|inhibition amplifies|nmod|END_ENTITY	Evidence that the protein C activation pathway amplifies the inhibition of thrombin generation by recombinant human thrombomodulin in plasma .
8381406	0	thrombin	76,84	thrombomodulin	34,48	thrombin	thrombomodulin	2147	7056	Gene	Gene	molecule|nmod|START_ENTITY binds|dobj|molecule binds|nsubj|moiety moiety|nmod|END_ENTITY	The chondroitin_sulfate moiety of thrombomodulin binds a second molecule of thrombin .
8384442	0	thrombin	154,162	thrombomodulin	43,57	thrombin	thrombomodulin	2147	7056	Gene	Gene	activator|nmod|START_ENTITY activator|nsubj|Role Role|nmod|component component|nmod|END_ENTITY	Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thrombin .
8391310	0	thrombin	87,95	thrombomodulin	18,32	thrombin	thrombomodulin	2147	7056	Gene	Gene	attenuates|nmod|START_ENTITY attenuates|nsubj|END_ENTITY	Recombinant human thrombomodulin attenuates human endothelial cell activation by human thrombin .
8940162	0	thrombin	50,58	thrombomodulin	13,27	thrombin	thrombomodulin	2147	7056	Gene	Gene	shape|nmod|START_ENTITY shape|nmod|END_ENTITY	The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy .
9712290	0	thrombin	73,81	thrombomodulin	112,126	thrombin	thrombomodulin	2147	7056	Gene	Gene	activator|nmod|START_ENTITY inactivation|nmod|activator inactivation|dep|effect effect|nmod|END_ENTITY	The inactivation of single-chain urokinase-type plasminogen activator by thrombin in a plasma milieu : effect of thrombomodulin .
10678148	0	thrombin	140,148	thrombospondin	114,128	thrombin	thrombospondin	2147	7057	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Dauricine inhibits redistribution of platelet membrane glycoprotein_IV and release of intracellular alpha-granule thrombospondin induced by thrombin .
11522018	0	thrombin	139,147	thrombospondin	38,52	thrombin	thrombospondin	2147	7057	Gene	Gene	concentrations|compound|START_ENTITY stimulated|nmod|concentrations stimulated|nsubj|END_ENTITY	Complementary roles for fibrin -LRB- ogen -RRB- , thrombospondin and vWF in mediating shear-dependent aggregation of platelets stimulated at threshold thrombin concentrations .
3705001	0	thrombin	110,118	thrombospondin	26,40	thrombin	thrombospondin	2147	7057	Gene	Gene	concentrations|nmod|START_ENTITY induced|nmod|concentrations induced|nsubj|involvement involvement|nmod|END_ENTITY	Functional involvement of thrombospondin in platelet_aggregation induced by low versus high concentrations of thrombin .
7654703	0	thrombin	140,148	thrombospondin	106,120	thrombin	thrombospondin	2147	7057	Gene	Gene	interactions|nmod|START_ENTITY resonance|dep|interactions resonance|nmod|environment environment|nmod|groups groups|nmod|END_ENTITY	Electron spin resonance and fluorescence studies of the conformational environment of the thiol groups of thrombospondin : interactions with thrombin .
17922340	0	thrombin	74,82	thrombospondin-1	46,62	thrombin	thrombospondin-1	2147	7057	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells .
11601238	0	thrombin	15,23	tissue_factor	27,40	thrombin	tissue factor	280685(Tax:9913)	101909187	Gene	Gene	START_ENTITY|nmod|activity activity|compound|END_ENTITY	-LSB- The effect of thrombin on tissue_factor activity in cultured bovine aortic endothelial cells and its correlation with PKC pathway -RSB- .
9684808	0	thrombin	58,66	tissue_plasminogen_activator	98,126	thrombin	tissue plasminogen activator	29251(Tax:10116)	25692(Tax:10116)	Gene	Gene	inhibitor|compound|START_ENTITY BCH-2763|appos|inhibitor BCH-2763|nmod|combination combination|nmod|END_ENTITY	Effective use of BCH-2763 , a new potent injectable direct thrombin inhibitor , in combination with tissue_plasminogen_activator -LRB- tPA -RRB- in a rat arterial thrombolysis model .
23131192	0	thrombin	57,65	transforming_growth_factor_beta_1	93,126	thrombin	transforming growth factor beta 1	280685(Tax:9913)	282089(Tax:9913)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Evaluation of the effect of calcium_gluconate and bovine thrombin on the temporal release of transforming_growth_factor_beta_1 and platelet-derived growth factor isoform BB from feline platelet concentrates .
10996659	0	thrombin	73,81	urokinase-type_plasminogen_activator	33,69	thrombin	urokinase-type plasminogen activator	2147	5328	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	The inactivation of single-chain urokinase-type_plasminogen_activator by thrombin on cultured human endothelial cells .
12213885	0	thrombin	24,32	vascular_endothelial_growth_factor	98,132	thrombin	vascular endothelial growth factor	2147	7422	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Differential effects of thrombin and hypoxia on endometrial stromal and glandular epithelial cell vascular_endothelial_growth_factor expression .
10764685	0	thrombin	123,131	vitronectin	150,161	thrombin	vitronectin	2147	7448	Gene	Gene	activity|compound|START_ENTITY activity|nmod|complexes complexes|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
10764685	0	thrombin	18,26	vitronectin	150,161	thrombin	vitronectin	2147	7448	Gene	Gene	Colocalization|nmod|START_ENTITY Colocalization|dep|mechanism mechanism|nmod|activity activity|nmod|complexes complexes|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
15386385	0	thrombin	58,66	von_Hippel-Lindau	0,17	thrombin	von Hippel-Lindau	2147	7428	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|amod|END_ENTITY	von_Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation .
12645517	0	thrombin-activable_fibrinolysis_inhibitor	31,72	TAFI	74,78	thrombin-activable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Acute phase mediators modulate thrombin-activable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene expression in HepG2 cells .
11565542	0	thrombin-activatable_fibrinolysis_inhibitor	89,132	TAFI	134,138	thrombin-activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel , possibly functional , single nucleotide polymorphism in the coding region of the thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene is also associated with TAFI levels .
17264944	0	thrombin-activatable_fibrinolysis_inhibitor	21,64	TAFI	66,70	thrombin-activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	variation|nmod|START_ENTITY variation|appos|END_ENTITY	Genetic variation in thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- is associated with the risk of splanchnic_vein_thrombosis .
18612536	0	thrombin-activatable_fibrinolysis_inhibitor	104,147	TAFI	149,153	thrombin-activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Absolute risk of venous and arterial thromboembolism in thrombophilic families is not increased by high thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- levels .
19967152	0	thrombin-activatable_fibrinolysis_inhibitor	14,57	TAFI	59,63	thrombin-activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of thrombin-activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- is up-regulated by increase in intracellular cyclic_AMP levels in cultured HepG2 cells .
16772741	0	thrombin-activatable_fibrinolysis_inhibitor	68,111	thrombin	13,21	thrombin-activatable fibrinolysis inhibitor	thrombin	1361	2147	Gene	Gene	formation|nmod|START_ENTITY formation|amod|END_ENTITY	Evolution of thrombin formation and fibrinolysis markers , including thrombin-activatable_fibrinolysis_inhibitor , during severe meningococcemia .
19233920	0	thrombin-activatable_fibrinolysis_inhibitor	102,145	tissue_factor_pathway_inhibitor	55,86	thrombin-activatable fibrinolysis inhibitor	tissue factor pathway inhibitor	1361	7035	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Increased plasminogen_activator_inhibitor-1 , decreased tissue_factor_pathway_inhibitor , and unchanged thrombin-activatable_fibrinolysis_inhibitor levels in patients with primary_hyperparathyroidism .
11341503	0	thrombin_activatable_fibrinolysis_inhibitor	14,57	TAFI	59,63	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Low levels of thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- in patients with chronic liver_disease .
12871455	0	thrombin_activatable_fibrinolysis_inhibitor	8,51	TAFI	53,57	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- in patients with acute_pulmonary_embolism .
14669439	0	thrombin_activatable_fibrinolysis_inhibitor	18,61	TAFI	63,67	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	-LSB- Concentration of thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- in cord blood and maternal blood during labor -RSB- .
14719174	0	thrombin_activatable_fibrinolysis_inhibitor	53,96	TAFI	98,102	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The impact of single nucleotide polymorphisms of the thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene on TAFI antigen levels in healthy children and pediatric oncology patients .
16803573	0	thrombin_activatable_fibrinolysis_inhibitor	38,81	TAFI	83,87	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The effect of genetic variants in the thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- gene on TAFI-antigen levels , clot lysis time and the risk of venous_thrombosis .
16959692	0	thrombin_activatable_fibrinolysis_inhibitor	18,61	TAFI	63,67	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Decrements in the thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- levels in association with orlistat treatment in obesity .
17090955	0	thrombin_activatable_fibrinolysis_inhibitor	9,52	TAFI	54,58	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Elevated thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- antigen levels in overt and subclinical_hypothyroid patients were reduced by levothyroxine replacement .
17579260	0	thrombin_activatable_fibrinolysis_inhibitor	29,72	TAFI	74,78	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Plasma levels of unactivated thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- are down-regulated in young adult women : analysis of a normal Japanese population .
23256818	0	thrombin_activatable_fibrinolysis_inhibitor	32,75	TAFI	77,81	thrombin activatable fibrinolysis inhibitor	TAFI	1361	1361	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Effect of warfarin treatment on thrombin_activatable_fibrinolysis_inhibitor -LRB- TAFI -RRB- activation and TAFI-mediated inhibition of fibrinolysis .
8058766	0	thrombin_receptor	78,95	Granzyme_A	0,10	thrombin receptor	Granzyme A	14062(Tax:10090)	14938(Tax:10090)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Granzyme_A released upon stimulation of cytotoxic T lymphocytes activates the thrombin_receptor on neuronal cells and astrocytes .
11598900	0	thrombin_receptor	18,35	PAR-1	37,42	thrombin receptor	PAR-1	25439(Tax:10116)	25439(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the thrombin_receptor -LRB- PAR-1 -RRB- during rat skeletal muscle differentiation .
11733402	0	thrombin_receptor	92,109	PAR-1	111,116	thrombin receptor	PAR-1	25439(Tax:10116)	25439(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin_receptor -LRB- PAR-1 -RRB- expression : role of the glucocorticoid receptor .
11967197	0	thrombin_receptor	36,53	Thrombin	0,8	thrombin receptor	Thrombin	526585(Tax:9913)	280685(Tax:9913)	Gene	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Thrombin generation and presence of thrombin_receptor in ovarian follicles .
9178727	0	thrombin_receptor	82,99	Thrombin	0,8	thrombin receptor	Thrombin	526585(Tax:9913)	280685(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin_receptor in cultured bovine smooth muscle cells .
8756541	0	thrombin_receptor	27,44	thrombin	71,79	thrombin receptor	thrombin	25439(Tax:10116)	29251(Tax:10116)	Gene	Gene	stimulation|compound|START_ENTITY stimulation|nmod|END_ENTITY	Rat uterine stromal cells : thrombin_receptor and growth stimulation by thrombin .
9178727	0	thrombin_receptor	82,99	thrombomodulin	17,31	thrombin receptor	thrombomodulin	526585(Tax:9913)	281529(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin_receptor in cultured bovine smooth muscle cells .
19278588	0	thrombomodulin	32,46	C5a	11,14	thrombomodulin	C5a	7056	728	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	-LSB- Effect of C5a on expression of thrombomodulin in endothelial cells in vitro -RSB- .
23844043	0	thrombomodulin	52,66	ERK1/2	26,32	thrombomodulin	ERK1/2	7056	5595;5594	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	UVB irradiation regulates ERK1/2 - and p53-dependent thrombomodulin expression in human keratinocytes .
18579691	0	thrombomodulin	39,53	HuR	20,23	thrombomodulin	HuR	7056	1994	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	RNA-binding protein HuR interacts with thrombomodulin 5 ` untranslated region and represses internal ribosome entry site-mediated translation under IL-1_beta treatment .
7669668	0	thrombomodulin	31,45	Major_basic_protein	0,19	thrombomodulin	Major basic protein	7056	4155	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Major_basic_protein binding to thrombomodulin potentially contributes to the thrombosis in patients with eosinophilia .
19638712	0	thrombomodulin	66,80	P-selectin	10,20	thrombomodulin	P-selectin	7056	6403	Gene	Gene	START_ENTITY|nsubj|expression expression|amod|END_ENTITY	Increased P-selectin expression on platelets and decreased plasma thrombomodulin in Fontan patients .
17379830	0	thrombomodulin	32,46	Protease_nexin-1	0,16	thrombomodulin	Protease nexin-1	7056	5270	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protease_nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect .
17287633	0	thrombomodulin	114,128	THP-1	147,152	thrombomodulin	THP-1	7056	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|line line|amod|monocytic monocytic|amod|END_ENTITY	Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes : effect of serum on thrombomodulin expression in the THP-1 monocytic cell line .
17287633	0	thrombomodulin	38,52	THP-1	147,152	thrombomodulin	THP-1	7056	2736	Gene	Gene	expression|compound|START_ENTITY down-regulates|dep|expression down-regulates|dep|effect effect|nmod|serum serum|nmod|expression expression|nmod|line line|amod|monocytic monocytic|amod|END_ENTITY	Lipopolysaccharide down-regulates the thrombomodulin expression of peripheral blood monocytes : effect of serum on thrombomodulin expression in the THP-1 monocytic cell line .
9594445	0	thrombomodulin	54,68	THP-1	106,111	thrombomodulin	THP-1	7056	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cell cell|compound|END_ENTITY	Differential effect of tumor_necrosis_factor-alpha on thrombomodulin gene expression by human monocytoid -LRB- THP-1 -RRB- cell versus endothelial cells .
1328724	0	thrombomodulin	22,36	TM	38,40	thrombomodulin	TM	7056	7056	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	-LSB- Evaluation of plasma thrombomodulin -LRB- TM -RRB- levels in patients with liver_disease -RSB- .
20116378	0	thrombomodulin	19,33	TM	35,37	thrombomodulin	TM	7056	7056	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	JNK-ATF-2 inhibits thrombomodulin -LRB- TM -RRB- expression by recruiting histone_deacetylase4 -LRB- HDAC4 -RRB- and forming a transcriptional repression complex in the TM promoter .
7680353	0	thrombomodulin	41,55	TM	57,59	thrombomodulin	TM	7056	7056	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Relationship of thyroid states and serum thrombomodulin -LRB- TM -RRB- levels in patients with Graves ' _ disease : TM , a possible new marker of the peripheral activity of thyroid hormones .
9022347	0	thrombomodulin	16,30	TM	31,33	thrombomodulin	TM	7056	7056	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Study of serum thrombomodulin -LRB- TM -RRB- levels in patients with hyper - _ or_hypo - _ thyroidism -RSB- .
15733976	0	thrombomodulin	55,69	TNF-alpha	11,20	thrombomodulin	TNF-alpha	7056	7124	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial_protein_C_receptor in human endothelial cells .
10464282	0	thrombomodulin	24,38	Thrombin	0,8	thrombomodulin	Thrombin	7056	2147	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Thrombin interacts with thrombomodulin , protein C , and thrombin-activatable_fibrinolysis_inhibitor via specific and distinct domains .
18568955	0	thrombomodulin	23,37	Thrombin	0,8	thrombomodulin	Thrombin	7056	2147	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells .
7613475	0	thrombomodulin	44,58	Thrombin	0,8	thrombomodulin	Thrombin	7056	2147	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|END_ENTITY	Thrombin inhibition by cyclic peptides from thrombomodulin .
9178727	0	thrombomodulin	17,31	Thrombin	0,8	thrombomodulin	Thrombin	281529(Tax:9913)	280685(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin_receptor in cultured bovine smooth muscle cells .
2854203	0	thrombomodulin	54,68	Tumor_necrosis_factor	0,21	thrombomodulin	Tumor necrosis factor	7056	7124	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene suppresses|dobj|transcription suppresses|nsubj|END_ENTITY	Tumor_necrosis_factor suppresses transcription of the thrombomodulin gene in endothelial cells .
2154059	0	thrombomodulin	20,34	antithrombin_III	76,92	thrombomodulin	antithrombin III	7056	462	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of human thrombomodulin on the inactivation of thrombin by human antithrombin_III .
8052962	0	thrombomodulin	37,51	antithrombin_III	150,166	thrombomodulin	antithrombin III	7056	304917(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|levels levels|nmod|END_ENTITY	Effects of recombinant human soluble thrombomodulin -LRB- rhs-TM -RRB- on a rat model of disseminated_intravascular_coagulation with decreased levels of plasma antithrombin_III .
2536746	1	thrombomodulin	100,114	epidermal_growth_factor	47,70	thrombomodulin	epidermal growth factor	7056	1950	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Residues 310-486 from the epidermal_growth_factor precursor homology domain of thrombomodulin will accelerate protein C activation .
2822406	0	thrombomodulin	14,28	fibrinogen	48,58	thrombomodulin	fibrinogen	7056	2244	Gene	Gene	START_ENTITY|nmod|cleavage cleavage|nmod|END_ENTITY	The effect of thrombomodulin on the cleavage of fibrinogen and fibrinogen fragments by thrombin .
23339448	0	thrombomodulin	153,167	high_mobility_group_box_1	14,39	thrombomodulin	high mobility group box 1	7056	3146	Gene	Gene	systemic_inflammatory_response_syndrome|nmod|START_ENTITY complicated|nmod|systemic_inflammatory_response_syndrome complicated|nsubj|Role Role|nmod|END_ENTITY	Role of serum high_mobility_group_box_1 in hematological_malignancies complicated with systemic_inflammatory_response_syndrome and effect of recombinant thrombomodulin .
23607598	0	thrombomodulin	83,97	high_mobility_group_box_1	15,40	thrombomodulin	high mobility group box 1	21824(Tax:10090)	15289(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of high_mobility_group_box_1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory_distress_syndrome .
24498917	0	thrombomodulin	8,22	high_mobility_group_box_1	96,121	thrombomodulin	high mobility group box 1	83580(Tax:10116)	25459(Tax:10116)	Gene	Gene	attenuates|compound|START_ENTITY sinusoidal_obstruction_syndrome|nsubj|attenuates sinusoidal_obstruction_syndrome|nmod|suppression suppression|nmod|END_ENTITY	Soluble thrombomodulin attenuates sinusoidal_obstruction_syndrome in rat through suppression of high_mobility_group_box_1 .
11013045	0	thrombomodulin	12,26	thrombin	89,97	thrombomodulin	thrombin	7056	2147	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Recombinant thrombomodulin inhibits arterial smooth muscle cell proliferation induced by thrombin .
12068020	0	thrombomodulin	33,47	thrombin	4,12	thrombomodulin	thrombin	7056	2147	Gene	Gene	recognizing|dobj|START_ENTITY epitope|acl|recognizing epitope|compound|END_ENTITY	The thrombin epitope recognizing thrombomodulin is a highly cooperative hot spot in exosite I .
1317850	0	thrombomodulin	50,64	thrombin	102,110	thrombomodulin	thrombin	7056	2147	Gene	Gene	bind|compound|START_ENTITY domains|nmod|bind factor-like|dobj|domains factor-like|nmod|exosite exosite|nmod|END_ENTITY	The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity .
15307903	0	thrombomodulin	39,53	thrombin	108,116	thrombomodulin	thrombin	83580(Tax:10116)	29251(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY implicates|nsubj|effects implicates|dobj|END_ENTITY	Neuroprotective effects of recombinant thrombomodulin in controlled contusion spinal_cord_injury implicates thrombin signaling .
16376423	0	thrombomodulin	34,48	thrombin	91,99	thrombomodulin	thrombin	7056	2147	Gene	Gene	containing|dobj|START_ENTITY films|acl|containing inhibit|nsubj|films inhibit|dobj|generation generation|amod|END_ENTITY	Membrane-mimetic films containing thrombomodulin and heparin inhibit tissue factor-induced thrombin generation in a flow model .
1660464	0	thrombomodulin	55,69	thrombin	19,27	thrombomodulin	thrombin	7056	2147	Gene	Gene	altered|nmod|START_ENTITY altered|nsubjpass|site site|nmod|END_ENTITY	The active site of thrombin is altered upon binding to thrombomodulin .
1678522	0	thrombomodulin	79,93	thrombin	31,39	thrombomodulin	thrombin	7056	2147	Gene	Gene	induced|nmod|START_ENTITY switch|acl|induced mimics|dobj|switch mimics|nsubj|substitution substitution|nmod|END_ENTITY	Glu-192 -- Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin .
18444940	0	thrombomodulin	4,18	thrombin	31,39	thrombomodulin	thrombin	7056	2147	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI .
1964460	0	thrombomodulin	32,46	thrombin	81,89	thrombomodulin	thrombin	7056	2147	Gene	Gene	antibodies|nmod|START_ENTITY antibodies|acl:relcl|recognize recognize|iobj|sites sites|nmod|END_ENTITY	Monoclonal antibodies for human thrombomodulin which recognize binding sites for thrombin and protein C. Monoclonal antibodies for human thrombomodulin , a cofactor for thrombin-catalyzed activation of protein C , were prepared and their epitopes characterized .
19656282	0	thrombomodulin	19,33	thrombin	53,61	thrombomodulin	thrombin	7056	2147	Gene	Gene	activation|compound|START_ENTITY basis|nmod|activation basis|nmod|END_ENTITY	Molecular basis of thrombomodulin activation of slow thrombin .
21130429	0	thrombomodulin	58,72	thrombin	10,18	thrombomodulin	thrombin	7056	2147	Gene	Gene	presence|nmod|START_ENTITY measured|nmod|presence measured|nsubj|generation generation|compound|END_ENTITY	Increased thrombin generation measured in the presence of thrombomodulin in women with early pregnancy_loss .
2154059	0	thrombomodulin	20,34	thrombin	58,66	thrombomodulin	thrombin	7056	2147	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|inactivation inactivation|nmod|END_ENTITY	The effect of human thrombomodulin on the inactivation of thrombin by human antithrombin_III .
2161655	0	thrombomodulin	44,58	thrombin	10,18	thrombomodulin	thrombin	7056	2147	Gene	Gene	affinity|nmod|START_ENTITY affinity|compound|END_ENTITY	Decreased thrombin affinity of cell-surface thrombomodulin following treatment of cultured endothelial cells with beta-D-xyloside .
25193406	0	thrombomodulin	96,110	thrombin	159,167	thrombomodulin	thrombin	7056	2147	Gene	Gene	presence|nmod|START_ENTITY dabigatran|nmod|presence effect|nmod|dabigatran unrelated|nsubj|effect unrelated|nmod|increase increase|nmod|generation generation|compound|END_ENTITY	The paradoxical antifibrinolytic effect of dabigatran and argatroban in the presence of soluble thrombomodulin is unrelated to protein_C-dependent increase of thrombin generation .
2538465	0	thrombomodulin	70,84	thrombin	102,110	thrombomodulin	thrombin	7056	2147	Gene	Gene	structures|nmod|START_ENTITY composed|nmod|structures domain|acl|composed essential|nsubj|domain essential|nmod|END_ENTITY	A domain composed of epidermal growth factor-like structures of human thrombomodulin is essential for thrombin binding and for protein C activation .
2829375	0	thrombomodulin	21,35	thrombin	59,67	thrombomodulin	thrombin	7056	2147	Gene	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	The effects of human thrombomodulin on the inactivation of thrombin by its serum inhibitors .
2847349	0	thrombomodulin	42,56	thrombin	22,30	thrombomodulin	thrombin	7056	2147	Gene	Gene	effect|nmod|START_ENTITY Modification|dep|effect Modification|nmod|END_ENTITY	Modification of human thrombin : effect on thrombomodulin binding .
2848597	0	thrombomodulin	11,25	thrombin	38,46	thrombomodulin	thrombin	100008887(Tax:9986)	100009146(Tax:9986)	Gene	Gene	START_ENTITY|nmod|functions functions|compound|END_ENTITY	-LSB- Effect of thrombomodulin on specific thrombin functions : fibrinogen coagulation and thrombocyte aggregation -RSB- .
2984256	0	thrombomodulin	6,20	thrombin	83,91	thrombomodulin	thrombin	7056	2147	Gene	Gene	inhibitor|nsubj|START_ENTITY inhibitor|nmod|activity activity|nmod|END_ENTITY	Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin .
3005304	0	thrombomodulin	21,35	thrombin	65,73	thrombomodulin	thrombin	281529(Tax:9913)	280685(Tax:9913)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|specificity specificity|nmod|END_ENTITY	The effect of bovine thrombomodulin on the specificity of bovine thrombin .
3028582	0	thrombomodulin	127,141	thrombin	54,62	thrombomodulin	thrombin	100008887(Tax:9986)	100009146(Tax:9986)	Gene	Gene	-RSB-|compound|START_ENTITY domain|nmod|-RSB- role|nmod|domain Effect|dep|role Effect|nmod|thrombomodulin thrombomodulin|nmod|inhibition inhibition|nmod|END_ENTITY	-LSB- Effect of rabbit thrombomodulin on the inhibition of thrombin by the antithrombin-heparin complex : role of the acid domain of thrombomodulin -RSB- .
3028582	0	thrombomodulin	18,32	thrombin	54,62	thrombomodulin	thrombin	100008887(Tax:9986)	100009146(Tax:9986)	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	-LSB- Effect of rabbit thrombomodulin on the inhibition of thrombin by the antithrombin-heparin complex : role of the acid domain of thrombomodulin -RSB- .
7947765	0	thrombomodulin	58,72	thrombin	88,96	thrombomodulin	thrombin	7056	2147	Gene	Gene	domain|nmod|START_ENTITY nonadecapeptide|nmod|domain Structure|nmod|nonadecapeptide complexed|nsubj|Structure complexed|nmod|END_ENTITY	Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin .
8259542	0	thrombomodulin	116,130	thrombin	75,83	thrombomodulin	thrombin	7056	2147	Gene	Gene	amplifies|nmod|START_ENTITY amplifies|dobj|inhibition inhibition|nmod|generation generation|compound|END_ENTITY	Evidence that the protein C activation pathway amplifies the inhibition of thrombin generation by recombinant human thrombomodulin in plasma .
8381406	0	thrombomodulin	34,48	thrombin	76,84	thrombomodulin	thrombin	7056	2147	Gene	Gene	moiety|nmod|START_ENTITY binds|nsubj|moiety binds|dobj|molecule molecule|nmod|END_ENTITY	The chondroitin_sulfate moiety of thrombomodulin binds a second molecule of thrombin .
8384442	0	thrombomodulin	43,57	thrombin	154,162	thrombomodulin	thrombin	7056	2147	Gene	Gene	component|nmod|START_ENTITY Role|nmod|component activator|nsubj|Role activator|nmod|END_ENTITY	Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thrombin .
8391310	0	thrombomodulin	18,32	thrombin	87,95	thrombomodulin	thrombin	7056	2147	Gene	Gene	attenuates|nsubj|START_ENTITY attenuates|nmod|END_ENTITY	Recombinant human thrombomodulin attenuates human endothelial cell activation by human thrombin .
8940162	0	thrombomodulin	13,27	thrombin	50,58	thrombomodulin	thrombin	7056	2147	Gene	Gene	shape|nmod|START_ENTITY shape|nmod|END_ENTITY	The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy .
9712290	0	thrombomodulin	112,126	thrombin	73,81	thrombomodulin	thrombin	7056	2147	Gene	Gene	effect|nmod|START_ENTITY inactivation|dep|effect inactivation|nmod|activator activator|nmod|END_ENTITY	The inactivation of single-chain urokinase-type plasminogen activator by thrombin in a plasma milieu : effect of thrombomodulin .
9178727	0	thrombomodulin	17,31	thrombin_receptor	82,99	thrombomodulin	thrombin receptor	281529(Tax:9913)	526585(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Thrombin induces thrombomodulin mRNA expression via the proteolytically activated thrombin_receptor in cultured bovine smooth muscle cells .
9848877	0	thrombomodulin	14,28	thrombomodulin	94,108	thrombomodulin	thrombomodulin	7056	7056	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of thrombomodulin in atherosclerotic_lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells .
9848877	0	thrombomodulin	94,108	thrombomodulin	14,28	thrombomodulin	thrombomodulin	7056	7056	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of thrombomodulin in atherosclerotic_lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells .
1846762	0	thrombomodulin	14,28	tumor_necrosis_factor	85,106	thrombomodulin	tumor necrosis factor	7056	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|effects effects|nmod|END_ENTITY	Expression of thrombomodulin by smooth muscle cells in culture : different effects of tumor_necrosis_factor and cyclic_adenosine_monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture .
1846762	0	thrombomodulin	145,159	tumor_necrosis_factor	85,106	thrombomodulin	tumor necrosis factor	7056	7124	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Expression of thrombomodulin by smooth muscle cells in culture : different effects of tumor_necrosis_factor and cyclic_adenosine_monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture .
9594445	0	thrombomodulin	54,68	tumor_necrosis_factor-alpha	23,50	thrombomodulin	tumor necrosis factor-alpha	7056	7124	Gene	Gene	expression|compound|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Differential effect of tumor_necrosis_factor-alpha on thrombomodulin gene expression by human monocytoid -LRB- THP-1 -RRB- cell versus endothelial cells .
10494762	0	thrombomodulin_and_von_Willebrand_factor	63,103	tissue_factor_pathway_inhibitor	30,61	thrombomodulin and von Willebrand factor	tissue factor pathway inhibitor	7056;7450	7035	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Transcriptional expression of tissue_factor_pathway_inhibitor , thrombomodulin_and_von_Willebrand_factor in normal human tissues .
25485912	0	thrombopoietin	46,60	Ashwell-Morell_receptor	4,27	thrombopoietin	Ashwell-Morell receptor	7066	11318	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	The Ashwell-Morell_receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling .
11380418	0	thrombopoietin	108,122	CD34	90,94	thrombopoietin	CD34	7066	947	Gene	Gene	using|dobj|START_ENTITY END_ENTITY|xcomp|using	Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34 + cells using thrombopoietin .
11841696	0	thrombopoietin	87,101	CD34	69,73	thrombopoietin	CD34	7066	947	Gene	Gene	using|dobj|START_ENTITY END_ENTITY|xcomp|using	Megakaryothrombopoiesis during ex vivo expansion of human cord blood CD34 + cells using thrombopoietin .
10841078	0	thrombopoietin	24,38	Interleukin-6	0,13	thrombopoietin	Interleukin-6	7066	3569	Gene	Gene	production|compound|START_ENTITY increases|dobj|production increases|nsubj|END_ENTITY	Interleukin-6 increases thrombopoietin production in human hepatoma cells HepG2 and Hep3B .
7534285	0	thrombopoietin	18,32	Jak2	73,77	thrombopoietin	Jak2	21832(Tax:10090)	16452(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|phosphorylation phosphorylation|nmod|END_ENTITY	The c-Mpl_ligand -LRB- thrombopoietin -RRB- stimulates tyrosine phosphorylation of Jak2 , Shc , and c-Mpl .
10736563	0	thrombopoietin	44,58	MPL	76,79	thrombopoietin	MPL	7066	4352	Gene	Gene	interactions|nmod|START_ENTITY Determination|nmod|interactions END_ENTITY|nsubj|Determination	Determination of interactions between human thrombopoietin and its receptor MPL by yeast two-hybrid system and affinity biosensor .
22389068	0	thrombopoietin	53,67	MPL	20,23	thrombopoietin	MPL	7066	4352	Gene	Gene	sensitivity|compound|START_ENTITY results|nmod|sensitivity results|nsubj|mutation mutation|nmod|END_ENTITY	A novel mutation in MPL -LRB- Y252H -RRB- results in increased thrombopoietin sensitivity in essential thrombocythemia .
8637239	0	thrombopoietin	71,85	MPL	27,30	thrombopoietin	MPL	7066	4352	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|dobj|effects	Expression of the receptor MPL and proliferative effects of its ligand thrombopoietin on human leukemia cells .
8960108	0	thrombopoietin	14,28	MPL	57,60	thrombopoietin	MPL	7066	4352	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression of thrombopoietin and thrombopoietin receptor MPL in human leukemia-lymphoma and solid tumor cell lines .
10216080	0	thrombopoietin	79,93	Mpl	25,28	thrombopoietin	Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|nsubj|expression expression|nmod|END_ENTITY	High-level expression of Mpl in platelets and megakaryocytes is independent of thrombopoietin .
10381535	0	thrombopoietin	135,149	Mpl	83,86	thrombopoietin	Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	growth|nmod|START_ENTITY results|nmod|growth results|nsubj|Deletion Deletion|nmod|receptor receptor|nmod|END_ENTITY	Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding .
10671297	0	thrombopoietin	109,123	Mpl	59,62	thrombopoietin	Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	high-affinity|nmod|START_ENTITY essential|nmod|high-affinity essential|nsubj|loop loop|nmod|END_ENTITY	Tyrosine 462 of the membrane-proximal F ' - G ' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin .
10971406	0	thrombopoietin	17,31	Mpl	42,45	thrombopoietin	Mpl	7066	4352	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Mutations in the thrombopoietin receptor , Mpl , in children with congenital_amegakaryocytic_thrombocytopenia .
12006617	0	thrombopoietin	20,34	Mpl	79,82	thrombopoietin	Mpl	7066	4352	Gene	Gene	effects|nmod|START_ENTITY Distinct|dobj|effects Distinct|advcl|level level|nmod|END_ENTITY	Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells .
15071178	0	thrombopoietin	117,131	Mpl	21,24	thrombopoietin	Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY platelets|nmod|absence production|nmod|platelets causes|dobj|production causes|nsubj|screen screen|nmod|END_ENTITY	Suppressor screen in Mpl - / - mice : c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling .
20667107	0	thrombopoietin	26,40	Mpl	51,54	thrombopoietin	Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY pattern|nmod|receptor pattern|appos|END_ENTITY	Expression pattern of the thrombopoietin receptor -LRB- Mpl -RRB- in the murine central nervous system .
9685168	0	thrombopoietin	80,94	Mpl	0,3	thrombopoietin	Mpl	7066	4352	Gene	Gene	isolation|nmod|START_ENTITY virus|nmod|isolation END_ENTITY|nmod|virus	Mpl : from an acute myeloproliferative virus to the isolation of the long sought thrombopoietin .
10648384	0	thrombopoietin	57,71	Stromal_cell-derived_factor-1	0,29	thrombopoietin	Stromal cell-derived factor-1	21832(Tax:10090)	20315(Tax:10090)	Gene	Gene	acts|nmod|START_ENTITY acts|nsubj|END_ENTITY	Stromal_cell-derived_factor-1 -LRB- SDF-1 -RRB- acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells -LRB- CFU-MK -RRB- .
10936442	0	thrombopoietin	42,56	TPO	58,61	thrombopoietin	TPO	7066	7066	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Stressful delivery influences circulating thrombopoietin -LRB- TPO -RRB- levels in newborns : possible role for cortisol in TPO-mpl binding .
12101178	0	thrombopoietin	21,35	TPO	37,40	thrombopoietin	TPO	7066	7066	Gene	Gene	domain|nmod|START_ENTITY domain|appos|END_ENTITY	The glycan domain of thrombopoietin -LRB- TPO -RRB- acts in trans to enhance secretion of the hormone and other cytokines .
7498368	0	thrombopoietin	14,28	TPO	30,33	thrombopoietin	TPO	81811(Tax:10116)	81811(Tax:10116)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of thrombopoietin -LRB- TPO -RRB- by rat hepatocytes and hepatoma cell lines .
8950771	0	thrombopoietin	6,20	TPO	22,25	thrombopoietin	TPO	7066	7066	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum thrombopoietin -LRB- TPO -RRB- levels in patients with amegakaryocytic_thrombocytopenia are much higher than those with immune_thrombocytopenic_purpura .
20236022	0	thrombopoietin	24,38	Tpo	40,43	thrombopoietin	Tpo	81811(Tax:10116)	81811(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inflammation stimulates thrombopoietin -LRB- Tpo -RRB- expression in rat brain-derived microvascular endothelial cells , but suppresses Tpo in astrocytes and microglia .
14764528	0	thrombopoietin	145,159	c-MPL	98,103	thrombopoietin	c-MPL	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY encodes|nmod|receptor gene|acl:relcl|encodes gene|amod|END_ENTITY	Familial_essential_thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene , which encodes for the receptor for thrombopoietin .
10554816	0	thrombopoietin	34,48	c-Mpl	59,64	thrombopoietin	c-Mpl	7066	4352	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Human dendritic cells express the thrombopoietin receptor , c-Mpl .
10611229	0	thrombopoietin	95,109	c-Mpl	31,36	thrombopoietin	c-Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY Role|nmod|production Role|nmod|half half|nmod|domain domain|amod|END_ENTITY	Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo .
10918061	0	thrombopoietin	73,87	c-Mpl	98,103	thrombopoietin	c-Mpl	7066	4352	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor , c-Mpl .
11012212	0	thrombopoietin	21,35	c-Mpl	15,20	thrombopoietin	c-Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation .
12068799	0	thrombopoietin	34,48	c-Mpl	81,86	thrombopoietin	c-Mpl	7066	4352	Gene	Gene	measurement|nmod|START_ENTITY measurement|nmod|END_ENTITY	Simultaneous measurement of serum thrombopoietin and expression of megakaryocyte c-Mpl with clinical and laboratory correlates for myelofibrosis_with_myeloid_metaplasia .
15531462	0	thrombopoietin	9,23	c-Mpl	80,85	thrombopoietin	c-Mpl	7066	4352	Gene	Gene	levels|compound|START_ENTITY levels|nmod|sequence sequence|nmod|receptor receptor|appos|END_ENTITY	Elevated thrombopoietin levels and alterations in the sequence of its receptor , c-Mpl , in patients with Diamond-Blackfan_anemia .
16480521	0	thrombopoietin	4,18	c-Mpl	29,34	thrombopoietin	c-Mpl	7066	4352	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The thrombopoietin receptor , c-Mpl , is a selective surface marker for human hematopoietic stem cells .
18726378	0	thrombopoietin	47,61	c-Mpl	71,76	thrombopoietin	c-Mpl	7066	4352	Gene	Gene	receptor|compound|START_ENTITY interact|nmod|receptor proteins|acl:relcl|interact Screening|nmod|proteins END_ENTITY|nsubj|Screening	Screening of proteins that interact with human thrombopoietin receptor c-Mpl using yeast two-hybrid system .
25468569	0	thrombopoietin	23,37	c-Mpl	107,112	thrombopoietin	c-Mpl	7066	4352	Gene	Gene	response|compound|START_ENTITY regulates|dobj|response regulates|nmod|splicing splicing|nmod|END_ENTITY	Ott1 -LRB- Rbm15 -RRB- regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl .
7862460	0	thrombopoietin	87,101	c-Mpl	65,70	thrombopoietin	c-Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Structure and transcription of the genomic locus encoding murine c-Mpl , a receptor for thrombopoietin .
9448308	0	thrombopoietin	77,91	c-Mpl	53,58	thrombopoietin	c-Mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Hematopoietic stem cell deficiencies in mice lacking c-Mpl , the receptor for thrombopoietin .
9401284	0	thrombopoietin	10,24	c-Mpl_ligand	26,38	thrombopoietin	c-Mpl ligand	7066	7066	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of thrombopoietin -LRB- c-Mpl_ligand -RRB- alone and in combination with other hematopoietic growth factors on human megakaryocytopoiesis in serum-free cultures .
15071178	0	thrombopoietin	117,131	c-Myb	34,39	thrombopoietin	c-Myb	21832(Tax:10090)	17863(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY platelets|nmod|absence production|nmod|platelets causes|dobj|production causes|nsubj|screen screen|nmod|Mpl Mpl|dep|mutation mutation|amod|END_ENTITY	Suppressor screen in Mpl - / - mice : c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling .
10460590	0	thrombopoietin	15,29	c-mpl	48,53	thrombopoietin	c-mpl	7066	4352	Gene	Gene	START_ENTITY|nmod|receptor receptor|amod|END_ENTITY	Interaction of thrombopoietin with the platelet c-mpl receptor in plasma : binding , internalization , stability and pharmacokinetics .
14995067	0	thrombopoietin	45,59	c-mpl	20,25	thrombopoietin	c-mpl	7066	4352	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Modulation of human c-mpl gene expression by thrombopoietin through protein kinase C .
15102474	0	thrombopoietin	68,82	c-mpl	110,115	thrombopoietin	c-mpl	7066	4352	Gene	Gene	action|nmod|START_ENTITY necessary|nmod|action necessary|xcomp|lacking lacking|dobj|END_ENTITY	A functional erythropoietin_receptor is necessary for the action of thrombopoietin on erythroid cells lacking c-mpl .
8759880	0	thrombopoietin	34,48	c-mpl	27,32	thrombopoietin	c-mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	Activity|acl|START_ENTITY Activity|nmod|ligand ligand|nmod|END_ENTITY	Activity of the ligand for c-mpl , thrombopoietin , in early haemopoiesis .
8784480	0	thrombopoietin	75,89	c-mpl	8,13	thrombopoietin	c-mpl	7066	4352	Gene	Gene	Lack|nmod|START_ENTITY Lack|nmod|transcripts transcripts|amod|END_ENTITY	Lack of c-mpl proto-oncogene transcripts and growth-stimulatory effects of thrombopoietin on human small_cell_lung_cancer cell lines .
9196139	0	thrombopoietin	43,57	c-mpl	14,19	thrombopoietin	c-mpl	7066	4352	Gene	Gene	receptor|nmod|START_ENTITY mRNA|appos|receptor mRNA|amod|END_ENTITY	Expression of c-mpl mRNA , the receptor for thrombopoietin , in acute_myeloid_leukemia blasts identifies a group of patients with poor response to intensive chemotherapy .
9446653	0	thrombopoietin	115,129	c-mpl	33,38	thrombopoietin	c-mpl	21832(Tax:10090)	17480(Tax:10090)	Gene	Gene	evidence|nmod|START_ENTITY cells|dep|evidence expressed|nmod|cells expressed|nsubjpass|Thrombopoietin Thrombopoietin|appos|END_ENTITY	Thrombopoietin and its receptor , c-mpl , are constitutively expressed by mouse liver endothelial cells : evidence of thrombopoietin as a growth factor for liver endothelial cells .
9737683	0	thrombopoietin	91,105	c-mpl	170,175	thrombopoietin	c-mpl	7066	4352	Gene	Gene	differentiation|nmod|START_ENTITY differentiation|nmod|differentiation Inhibition|nmod|differentiation regulated|nsubjpass|Inhibition regulated|nmod|mechanisms mechanisms|nmod|lines lines|amod|UT-7 UT-7|dep|END_ENTITY	Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7 / c-mpl and TF-1 / c-mpl cell lines .
9737683	0	thrombopoietin	91,105	c-mpl	185,190	thrombopoietin	c-mpl	7066	4352	Gene	Gene	differentiation|nmod|START_ENTITY differentiation|nmod|differentiation Inhibition|nmod|differentiation regulated|nsubjpass|Inhibition regulated|nmod|mechanisms mechanisms|nmod|lines lines|amod|END_ENTITY	Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7 / c-mpl and TF-1 / c-mpl cell lines .
9260579	0	thrombopoietin	11,25	c-mpl_ligand	27,39	thrombopoietin	c-mpl ligand	7066	7066	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of thrombopoietin -LRB- c-mpl_ligand -RRB- on growth of blast cells from patients with transient abnormal_myelopoiesis and acute_myeloblastic_leukemia .
11474308	0	thrombopoietin	43,57	erythropoietin	72,86	thrombopoietin	erythropoietin	7066	2056	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	The role of the liver in the production of thrombopoietin compared with erythropoietin .
11554233	0	thrombopoietin	26,40	erythropoietin	64,78	thrombopoietin	erythropoietin	7066	2056	Gene	Gene	START_ENTITY|nmod|erythropoiesis erythropoiesis|nmod|END_ENTITY	The synergistic effect of thrombopoietin in erythropoiesis with erythropoietin and/or IL-3 and myelopoiesis with G-CSF or IL-3 from umbilical cord blood cells of full-term neonates .
12186362	0	thrombopoietin	26,40	erythropoietin	64,78	thrombopoietin	erythropoietin	7066	2056	Gene	Gene	START_ENTITY|nmod|erythropoiesis erythropoiesis|nmod|END_ENTITY	The synergistic effect of thrombopoietin in erythropoiesis with erythropoietin and/or IL-3 and myelopoiesis with G-CSF or IL-3 from umbilical cord blood cells of premature neonates .
15879702	0	thrombopoietin	15,29	erythropoietin	64,78	thrombopoietin	erythropoietin	7066	2056	Gene	Gene	cDNA|compound|START_ENTITY Half|nmod|cDNA confers|nsubj|Half confers|dobj|expression expression|nmod|END_ENTITY	3 ' - Half of the thrombopoietin cDNA confers higher expression of erythropoietin at the RNA level but not at the protein level .
19878361	0	thrombopoietin	7,21	erythropoietin	102,116	thrombopoietin	erythropoietin	7066	2056	Gene	Gene	START_ENTITY|nmod|patients patients|acl|receiving receiving|dobj|END_ENTITY	Plasma thrombopoietin level and platelet indices in hemodialysis patients receiving recombinant human erythropoietin .
10554817	0	thrombopoietin	87,101	flt3-ligand	103,114	thrombopoietin	flt3-ligand	7066	2323	Gene	Gene	granulocyte-colony_stimulating_factor|compound|START_ENTITY granulocyte-colony_stimulating_factor|amod|END_ENTITY	Myeloid differentiation of human cord blood CD34 + cells during ex vivo expansion using thrombopoietin , flt3-ligand and/or granulocyte-colony_stimulating_factor .
10216073	0	thrombopoietin	18,32	granulocyte_colony-stimulating_factor	53,90	thrombopoietin	granulocyte colony-stimulating factor	7066	1440	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Recombinant human thrombopoietin in combination with granulocyte_colony-stimulating_factor enhances mobilization of peripheral blood progenitor cells , increases peripheral blood platelet concentration , and accelerates hematopoietic recovery following high-dose chemotherapy .
10458926	0	thrombopoietin	56,70	megakaryocyte_growth_and_development_factor	11,54	thrombopoietin	megakaryocyte growth and development factor	21832(Tax:10090)	21832(Tax:10090)	Gene	Gene	Effects|appos|START_ENTITY Effects|nmod|END_ENTITY	Effects of megakaryocyte_growth_and_development_factor -LRB- thrombopoietin -RRB- on liver endothelial cells in vitro .
9678719	0	thrombopoietin	57,71	megakaryocyte_growth_and_development_factor	12,55	thrombopoietin	megakaryocyte growth and development factor	7066	7066	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of megakaryocyte_growth_and_development_factor -LRB- thrombopoietin -RRB- effects on blast cell and megakaryocyte growth in myelodysplasia .
11164105	0	thrombopoietin	54,68	prolactin-like_protein_E	7,31	thrombopoietin	prolactin-like protein E	7066	19113(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|amod|END_ENTITY	Murine prolactin-like_protein_E synergizes with human thrombopoietin to stimulate expansion of human megakaryocytes and their precursors .
11356906	0	thrombopoietin	66,80	protein_kinase_C-epsilon	15,39	thrombopoietin	protein kinase C-epsilon	21832(Tax:10090)	18754(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of protein_kinase_C-epsilon in signal transduction of thrombopoietin in enhancement of interleukin-3-dependent proliferation of primitive hematopoietic progenitors .
1379600	1	thrombospondin	101,115	CD36	91,95	thrombospondin	CD36	7057	948	Gene	Gene	receptor|compound|START_ENTITY Role|nmod|receptor Role|nmod|END_ENTITY	Role of CD36 as a thrombospondin receptor .
7688364	0	thrombospondin	27,41	CD36	118,122	thrombospondin	CD36	7057	948	Gene	Gene	SVTCG|nmod|START_ENTITY SVTCG|nmod|site site|nmod|receptor receptor|appos|END_ENTITY	Identification of SVTCG in thrombospondin as the conformation-dependent , high affinity binding site for its receptor , CD36 .
9609460	0	thrombospondin	43,57	TGF-beta	76,84	thrombospondin	TGF-beta	7057	7040	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	The fibronectin production is increased by thrombospondin via activation of TGF-beta in cultured human mesangial cells .
21526452	0	thrombospondin	27,41	THBS1	43,48	thrombospondin	THBS1	7057	7057	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of thrombospondin -LRB- THBS1 -RRB- in tumorigenic and nontumorigenic prostate epithelial cells in response to a chromatin-binding soy peptide .
10678148	0	thrombospondin	114,128	thrombin	140,148	thrombospondin	thrombin	7057	2147	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Dauricine inhibits redistribution of platelet membrane glycoprotein_IV and release of intracellular alpha-granule thrombospondin induced by thrombin .
11522018	0	thrombospondin	38,52	thrombin	139,147	thrombospondin	thrombin	7057	2147	Gene	Gene	stimulated|nsubj|START_ENTITY stimulated|nmod|concentrations concentrations|compound|END_ENTITY	Complementary roles for fibrin -LRB- ogen -RRB- , thrombospondin and vWF in mediating shear-dependent aggregation of platelets stimulated at threshold thrombin concentrations .
3705001	0	thrombospondin	26,40	thrombin	110,118	thrombospondin	thrombin	7057	2147	Gene	Gene	involvement|nmod|START_ENTITY induced|nsubj|involvement induced|nmod|concentrations concentrations|nmod|END_ENTITY	Functional involvement of thrombospondin in platelet_aggregation induced by low versus high concentrations of thrombin .
7654703	0	thrombospondin	106,120	thrombin	140,148	thrombospondin	thrombin	7057	2147	Gene	Gene	groups|nmod|START_ENTITY environment|nmod|groups resonance|nmod|environment resonance|dep|interactions interactions|nmod|END_ENTITY	Electron spin resonance and fluorescence studies of the conformational environment of the thiol groups of thrombospondin : interactions with thrombin .
14517432	0	thrombospondin	73,87	vascular_endothelial_growth_factor	28,62	thrombospondin	vascular endothelial growth factor	7057	7422	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding and displacement of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by thrombospondin : effect on human microvascular endothelial cell proliferation and angiogenesis .
14583433	0	thrombospondin-1	23,39	Angiotensin_II	0,14	thrombospondin-1	Angiotensin II	7057	183	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Angiotensin_II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK : a mechanism for activation of latent TGF-beta1 .
9245797	0	thrombospondin-1	49,65	CD36	0,4	thrombospondin-1	CD36	7057	948	Gene	Gene	effects|nmod|START_ENTITY mediates|dobj|effects mediates|nsubj|END_ENTITY	CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells .
9747513	0	thrombospondin-1	33,49	CD36	0,4	thrombospondin-1	CD36	21825(Tax:10090)	12491(Tax:10090)	Gene	Gene	binding|nmod|START_ENTITY mediates|dobj|binding mediates|nsubj|END_ENTITY	CD36 mediates binding of soluble thrombospondin-1 but not cell adhesion and haptotaxis on immobilized thrombospondin-1 .
12924949	0	thrombospondin-1	37,53	CD47	63,67	thrombospondin-1	CD47	7057	961	Gene	Gene	displays|amod|START_ENTITY domain|nmod|displays END_ENTITY|nsubj|domain	An amyloid-like C-terminal domain of thrombospondin-1 displays CD47 agonist activity requiring both VVM motifs .
16835222	0	thrombospondin-1	87,103	CD47	0,4	thrombospondin-1	CD47	21825(Tax:10090)	16423(Tax:10090)	Gene	Gene	necessary|advcl|START_ENTITY necessary|nsubj|END_ENTITY	CD47 is necessary for inhibition of nitric_oxide-stimulated vascular cell responses by thrombospondin-1 .
17916772	0	thrombospondin-1	9,25	CD47	26,30	thrombospondin-1	CD47	21825(Tax:10090)	16423(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|alleviates alleviates|nsubj|signaling signaling|compound|END_ENTITY	Blocking thrombospondin-1 / CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia .
18438125	0	thrombospondin-1	48,64	CD47	18,22	thrombospondin-1	CD47	7057	961	Gene	Gene	survival|amod|START_ENTITY Gene|nmod|survival Gene|nmod|ligation ligation|compound|END_ENTITY	Gene silencing of CD47 and antibody ligation of thrombospondin-1 enhance ischemic tissue survival in a porcine model : implications for human disease .
18855617	0	thrombospondin-1	51,67	CD47	68,72	thrombospondin-1	CD47	21825(Tax:10090)	16423(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY Enhancing|nmod|inhibition END_ENTITY|dep|Enhancing	Enhancing cardiovascular dynamics by inhibition of thrombospondin-1 / CD47 signaling .
19081017	0	thrombospondin-1	59,75	CD47	76,80	thrombospondin-1	CD47	21825(Tax:10090)	16423(Tax:10090)	Gene	Gene	limiting|xcomp|START_ENTITY injury|acl|limiting Treatment|nmod|injury Treatment|parataxis|signaling signaling|nsubj|END_ENTITY	Treatment of liver_ischemia-reperfusion injury by limiting thrombospondin-1 / CD47 signaling .
21343308	0	thrombospondin-1	124,140	CD47	59,63	thrombospondin-1	CD47	7057	961	Gene	Gene	signaling|advcl|START_ENTITY necessary|xcomp|signaling necessary|nsubj|modification modification|nmod|END_ENTITY	Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1 .
22266027	0	thrombospondin-1	26,42	CD47	114,118	thrombospondin-1	CD47	21825(Tax:10090)	16423(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|stress stress|nmod|END_ENTITY	The matricellular protein thrombospondin-1 globally regulates cardiovascular function and responses to stress via CD47 .
25779848	0	thrombospondin-1	29,45	CD47	55,59	thrombospondin-1	CD47	21825(Tax:10090)	16423(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY targeting|nmod|receptor END_ENTITY|nsubj|targeting	Therapeutic targeting of the thrombospondin-1 receptor CD47 to treat liver_cancer .
11134179	0	thrombospondin-1	66,82	Histidine-rich_glycoprotein	0,27	thrombospondin-1	Histidine-rich glycoprotein	7057	3273	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	Histidine-rich_glycoprotein inhibits the antiangiogenic effect of thrombospondin-1 .
16650813	0	thrombospondin-1	15,31	IL-18	0,5	thrombospondin-1	IL-18	7057	3606	Gene	Gene	production|amod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	IL-18 enhances thrombospondin-1 production in human gastric_cancer via JNK pathway .
14563713	0	thrombospondin-1	46,62	Integrin-associated_protein	0,27	thrombospondin-1	Integrin-associated protein	7057	961	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Integrin-associated_protein binding domain of thrombospondin-1 enhances insulin-like_growth_factor-I receptor signaling in vascular smooth muscle cells .
9478926	0	thrombospondin-1	45,61	Lysosomal_integral_membrane_protein_II	0,38	thrombospondin-1	Lysosomal integral membrane protein II	7057	950	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Lysosomal_integral_membrane_protein_II binds thrombospondin-1 .
9724633	0	thrombospondin-1	88,104	Muskelin	0,8	thrombospondin-1	Muskelin	21825(Tax:10090)	36386(Tax:7227)	Gene	Gene	mediator|nmod|START_ENTITY END_ENTITY|appos|mediator	Muskelin , a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1 .
23085760	0	thrombospondin-1	65,81	NOL7	27,31	thrombospondin-1	NOL7	7057	51406	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression .
23372933	0	thrombospondin-1	67,83	Peroxisome_proliferator-activated_receptor_gamma	0,48	thrombospondin-1	Peroxisome proliferator-activated receptor gamma	7057	5468	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARy -RRB- regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation .
12173300	0	thrombospondin-1	17,33	TSP-1	35,40	thrombospondin-1	TSP-1	7057	7057	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increased plasma thrombospondin-1 -LRB- TSP-1 -RRB- levels are associated with the TNF_alpha-308A allele in children with juvenile_dermatomyositis .
18652777	0	thrombospondin-1	25,41	TSP-1	43,48	thrombospondin-1	TSP-1	445442(Tax:10116)	445442(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of cilostazol on thrombospondin-1 -LRB- TSP-1 -RRB- expression changes in the myocardium of diabetic rats .
19762163	0	thrombospondin-1	83,99	TSP-1	101,106	thrombospondin-1	TSP-1	7057	7057	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vascular_endothelial_growth_factor -LRB- VEGF -RRB- , matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- , and thrombospondin-1 -LRB- TSP-1 -RRB- expression in urothelial_carcinomas .
21333695	0	thrombospondin-1	43,59	TSP-1	61,66	thrombospondin-1	TSP-1	7057	7057	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Role of JNK/ATF -2 pathway in inhibition of thrombospondin-1 -LRB- TSP-1 -RRB- expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells .
15817447	0	thrombospondin-1	62,78	Thrombin	0,8	thrombospondin-1	Thrombin	7057	2147	Gene	Gene	cells|amod|START_ENTITY genes|nmod|cells set|nmod|genes expression|nmod|set modulates|dobj|expression modulates|nsubj|END_ENTITY	Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascular endothelial cells .
11704858	0	thrombospondin-1	46,62	VEGF	29,33	thrombospondin-1	VEGF	7057	7422	Gene	Gene	production|amod|START_ENTITY END_ENTITY|dobj|production	p73 Overexpression increases VEGF and reduces thrombospondin-1 production : implications for tumor angiogenesis .
11530112	0	thrombospondin-1	27,43	angiotensin_II	63,77	thrombospondin-1	angiotensin II	445442(Tax:10116)	24179(Tax:10116)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|subtypes subtypes|amod|END_ENTITY	Differential regulation of thrombospondin-1 and fibronectin by angiotensin_II receptor subtypes in cultured endothelial cells .
17640965	0	thrombospondin-1	2,18	angiotensin_II	133,147	thrombospondin-1	angiotensin II	445442(Tax:10116)	24179(Tax:10116)	Gene	Gene	antagonist|amod|START_ENTITY antagonist|acl|transforming transforming|nmod|rats rats|nmod|END_ENTITY	A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin_II .
9223624	0	thrombospondin-1	14,30	angiotensin_II	45,59	thrombospondin-1	angiotensin II	445442(Tax:10116)	24179(Tax:10116)	Gene	Gene	production|amod|START_ENTITY Regulation|nmod|production Regulation|nmod|END_ENTITY	Regulation of thrombospondin-1 production by angiotensin_II in rat heart endothelial cells .
10849431	0	thrombospondin-1	75,91	beta-1	50,56	thrombospondin-1	beta-1	21825(Tax:10090)	15129(Tax:10090)	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Activation of platelet-transforming growth factor beta-1 in the absence of thrombospondin-1 .
18583030	0	thrombospondin-1	69,85	c-Myc	19,24	thrombospondin-1	c-Myc	7057	4609	Gene	Gene	START_ENTITY|nmod|regulation regulation|nmod|END_ENTITY	Down regulation of c-Myc and induction of an angiogenesis inhibitor , thrombospondin-1 , by 5-FU in human colon_cancer KM12C cells .
10393860	0	thrombospondin-1	56,72	p53	117,120	thrombospondin-1	p53	7057	7157	Gene	Gene	independent|amod|START_ENTITY independent|nmod|END_ENTITY	Human_cytomegalovirus infection decreases expression of thrombospondin-1 independent of the tumor suppressor protein p53 .
17922340	0	thrombospondin-1	46,62	thrombin	74,82	thrombospondin-1	thrombin	7057	2147	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells .
18467703	0	thrombospondin-1	70,86	thrombospondin-3	88,104	thrombospondin-1	thrombospondin-3	21825(Tax:10090)	21827(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Skeletal_abnormalities in mice lacking extracellular matrix proteins , thrombospondin-1 , _ thrombospondin-3 , _ thrombospondin-5 , and type IX collagen .
18467703	0	thrombospondin-1	70,86	thrombospondin-5	106,122	thrombospondin-1	thrombospondin-5	21825(Tax:10090)	12845(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Skeletal_abnormalities in mice lacking extracellular matrix proteins , thrombospondin-1 , _ thrombospondin-3 , _ thrombospondin-5 , and type IX collagen .
10194419	0	thrombospondin-1	138,154	transforming_growth_factor_beta1	13,45	thrombospondin-1	transforming growth factor beta1	7057	7040	Gene	Gene	synthesis|amod|START_ENTITY thyroid|nmod|synthesis thyroid|nsubj|Influence Influence|nmod|TGF-beta1 TGF-beta1|amod|END_ENTITY	Influence of transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- on the behaviour of porcine thyroid epithelial cells in primary culture through thrombospondin-1 synthesis .
16733556	1	thrombospondin-1	200,216	transforming_growth_factor_beta1	145,177	thrombospondin-1	transforming growth factor beta1	7057	7040	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	The involvement of transforming_growth_factor_beta1 and its activation by thrombospondin-1 .
10917542	0	thrombospondin-1	12,28	urokinase_plasminogen_activator_receptor	85,125	thrombospondin-1	urokinase plasminogen activator receptor	7057	5329	Gene	Gene	regulates|nsubj|START_ENTITY regulates|nmod|END_ENTITY	Tumour cell thrombospondin-1 regulates tumour cell adhesion and invasion through the urokinase_plasminogen_activator_receptor .
12873985	0	thrombospondin-1	115,131	vascular_endothelial_growth_factor	29,63	thrombospondin-1	vascular endothelial growth factor	7057	7422	Gene	Gene	limits|nmod|START_ENTITY limits|nsubj|inhibition inhibition|nmod|END_ENTITY	SiRNA-mediated inhibition of vascular_endothelial_growth_factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth .
12963968	0	thrombospondin-1	25,41	vascular_endothelial_growth_factor	68,102	thrombospondin-1	vascular endothelial growth factor	7057	7422	Gene	Gene	expression|amod|START_ENTITY significance|nmod|expression significance|nmod|relation relation|nmod|END_ENTITY	Clinical significance of thrombospondin-1 expression in relation to vascular_endothelial_growth_factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal_carcinoma .
21378271	0	thrombospondin-1	71,87	vascular_endothelial_growth_factor	15,49	thrombospondin-1	vascular endothelial growth factor	7057	7422	Gene	Gene	signaling|nmod|START_ENTITY Priming|acl|signaling Priming|nmod|END_ENTITY	Priming of the vascular_endothelial_growth_factor signaling pathway by thrombospondin-1 , CD36 , and spleen_tyrosine_kinase .
18467703	0	thrombospondin-3	88,104	thrombospondin-1	70,86	thrombospondin-3	thrombospondin-1	21827(Tax:10090)	21825(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Skeletal_abnormalities in mice lacking extracellular matrix proteins , thrombospondin-1 , _ thrombospondin-3 , _ thrombospondin-5 , and type IX collagen .
18467703	0	thrombospondin-3	88,104	thrombospondin-5	106,122	thrombospondin-3	thrombospondin-5	21827(Tax:10090)	12845(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Skeletal_abnormalities in mice lacking extracellular matrix proteins , thrombospondin-1 , _ thrombospondin-3 , _ thrombospondin-5 , and type IX collagen .
18467703	0	thrombospondin-5	106,122	thrombospondin-1	70,86	thrombospondin-5	thrombospondin-1	12845(Tax:10090)	21825(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Skeletal_abnormalities in mice lacking extracellular matrix proteins , thrombospondin-1 , _ thrombospondin-3 , _ thrombospondin-5 , and type IX collagen .
18467703	0	thrombospondin-5	106,122	thrombospondin-3	88,104	thrombospondin-5	thrombospondin-3	12845(Tax:10090)	21827(Tax:10090)	Gene	Gene	proteins|amod|START_ENTITY proteins|amod|END_ENTITY	Skeletal_abnormalities in mice lacking extracellular matrix proteins , thrombospondin-1 , _ thrombospondin-3 , _ thrombospondin-5 , and type IX collagen .
24587387	0	thrombospondin-related_adhesive_protein	30,69	TRAP	71,75	thrombospondin-related adhesive protein	TRAP	100187907	100187907	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Diversifying selection on the thrombospondin-related_adhesive_protein -LRB- TRAP -RRB- gene of Plasmodium_falciparum in Thailand .
20976175	0	thrombospondin_1	25,41	E2F-1	0,5	thrombospondin 1	E2F-1	7057	1869	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	E2F-1 directly regulates thrombospondin_1 expression .
20370578	0	thrombospondin_1	53,69	Fibroblast_growth_factor_8	0,26	thrombospondin 1	Fibroblast growth factor 8	7057	2253	Gene	Gene	downregulation|nmod|START_ENTITY downregulation|amod|END_ENTITY	Fibroblast_growth_factor_8 induced downregulation of thrombospondin_1 is mediated by the MEK/ERK and PI3K pathways in breast_cancer cells .
23677673	0	thrombospondin_1	47,63	FoxO1	12,17	thrombospondin 1	FoxO1	21825(Tax:10090)	56458(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulator|nmod|expression regulator|nsubj|END_ENTITY	Endothelial FoxO1 is an intrinsic regulator of thrombospondin_1 expression that restrains angiogenesis in ischemic muscle .
12101446	0	thrombospondin_1	99,115	SPARC	133,138	thrombospondin 1	SPARC	7057	6678	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Pathobiology of epiretinal and subretinal membranes : possible roles for the matricellular proteins thrombospondin_1 and osteonectin -LRB- SPARC -RRB- .
15526350	0	thrombospondin_1	45,61	TSP-1	63,68	thrombospondin 1	TSP-1	7057	7057	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Hepatocyte_growth_factor -LRB- HGF -RRB- downregulates thrombospondin_1 -LRB- TSP-1 -RRB- expression in thyroid_papillary_carcinoma cells .
12443715	0	thrombospondin_1	47,63	matrix_metalloproteinase_9	17,43	thrombospondin 1	matrix metalloproteinase 9	7057	4318	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of matrix_metalloproteinase_9 by thrombospondin_1 in gastric_cancer .
9336411	0	thrombospondin_1	32,48	proteinase	60,70	thrombospondin 1	proteinase	7057	100616101	Gene	Gene	correlation|nmod|START_ENTITY END_ENTITY|nsubj|correlation	Significant correlation between thrombospondin_1 and serine proteinase expression in rheumatoid_synovium .
7706271	0	thrombospondin_1	82,98	transforming_growth_factor-beta	14,45	thrombospondin 1	transforming growth factor-beta	7057	7040	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|activation activation|amod|END_ENTITY	Regulation of transforming_growth_factor-beta activation by discrete sequences of thrombospondin_1 .
24806621	0	thrombospondin_2	122,138	MiR-1246	0,8	thrombospondin 2	MiR-1246	7058	100302142	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	MiR-1246 promotes SiHa_cervical_cancer cell proliferation , invasion , and migration through suppression of its target gene thrombospondin_2 .
9249061	0	thrombospondin_2	68,84	THBS2	91,96	thrombospondin 2	THBS2	7058	7058	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the promoter and transcription start sites of the human thrombospondin_2 gene -LRB- THBS2 -RRB- .
12792739	0	thrombospondin_2	22,38	TSP2	40,44	thrombospondin 2	TSP2	7058	7058	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Overexpression of the thrombospondin_2 -LRB- TSP2 -RRB- gene modulated by the matrix metalloproteinase family expression and production in human colon_carcinoma cell line .
7558000	0	thrombospondin_3	40,56	THBS3	63,68	thrombospondin 3	THBS3	7059	7059	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structure and organization of the human thrombospondin_3 gene -LRB- THBS3 -RRB- .
8468055	0	thrombospondin_3	44,60	Thbs3	62,67	thrombospondin 3	Thbs3	21827(Tax:10090)	21827(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of the mouse thrombospondin_3 -LRB- Thbs3 -RRB- gene .
20590159	0	thromboxane_A2_receptor	90,113	Galphaq	56,63	thromboxane A2 receptor	Galphaq	6915	2776	Gene	Gene	complex|nmod|START_ENTITY END_ENTITY|nmod|complex	Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane_A2_receptor provides evidence of constitutive activity .
18698092	0	thromboxane_A2_receptor	24,47	Sp1	56,59	thromboxane A2 receptor	Sp1	6915	6667	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of the human thromboxane_A2_receptor gene by Sp1 , Egr1 , NF-E2 , GATA-1 , and Ets-1 in megakaryocytes .
21070398	0	thromboxane_A2_receptor	15,38	TBXA2R	40,46	thromboxane A2 receptor	TBXA2R	6915	6915	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of thromboxane_A2_receptor -LRB- TBXA2R -RRB- gene polymorphism in patients with aspirin-intolerant acute urticaria .
19325001	0	thromboxane_A2_receptor	19,42	steroidogenic_acute_regulatory	64,94	thromboxane A2 receptor	steroidogenic acute regulatory	21390(Tax:10090)	20845(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|regulation regulation|nmod|expression expression|amod|END_ENTITY	Involvement of the thromboxane_A2_receptor in the regulation of steroidogenic_acute_regulatory gene expression in murine Leydig cells .
8566050	0	thymic_stromal-derived_lymphopoietin	20,56	TSLP	58,62	thymic stromal-derived lymphopoietin	TSLP	53603(Tax:10090)	53603(Tax:10090)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of thymic_stromal-derived_lymphopoietin -LRB- TSLP -RRB- in murine B cell development in vitro .
21274737	0	thymic_stromal_lymphopoietin	6,34	CD80	58,62	thymic stromal lymphopoietin	CD80	85480	941	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|expression expression|nmod|END_ENTITY	Human thymic_stromal_lymphopoietin enhances expression of CD80 in human CD14 + monocytes/macrophages .
22888172	0	thymic_stromal_lymphopoietin	43,71	Interleukin-1b	0,14	thymic stromal lymphopoietin	Interleukin-1b	85480	3553	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	Interleukin-1b stimulates the secretion of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- from endometrioma stromal cells : possible involvement of TSLP in endometriosis .
17617600	0	thymic_stromal_lymphopoietin	47,75	TLR3	0,4	thymic stromal lymphopoietin	TLR3	85480	7098	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	TLR3 - and Th2 cytokine-dependent production of thymic_stromal_lymphopoietin in human airway epithelial cells .
21691053	0	thymic_stromal_lymphopoietin	34,62	TLR3	145,149	thymic stromal lymphopoietin	TLR3	85480	7098	Gene	Gene	expression|compound|START_ENTITY trigger|dobj|expression trigger|nmod|epithelium epithelium|dep|role role|nmod|END_ENTITY	Viral stimuli trigger exaggerated thymic_stromal_lymphopoietin expression by chronic_obstructive_pulmonary_disease epithelium : role of endosomal TLR3 and cytosolic RIG-I-like helicases .
19857905	0	thymic_stromal_lymphopoietin	23,51	TSLP	53,57	thymic stromal lymphopoietin	TSLP	85480	85480	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The regulatory role of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- in maternal-fetal_immune_tolerance during early human pregnancy .
21109412	0	thymic_stromal_lymphopoietin	12,40	TSLP	42,46	thymic stromal lymphopoietin	TSLP	85480	85480	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- in allergic_disorders .
21161346	0	thymic_stromal_lymphopoietin	8,36	TSLP	38,42	thymic stromal lymphopoietin	TSLP	53603(Tax:10090)	53603(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- in palifermin-mediated immune modulation and protection from acute murine graft-versus-host_disease .
24647421	0	thymic_stromal_lymphopoietin	12,40	TSLP	42,46	thymic stromal lymphopoietin	TSLP	85480	85480	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	-LSB- Effects of thymic_stromal_lymphopoietin -LRB- TSLP -RRB- genotypes on asthma phenotypes defined by the atopy cluster - influence of smoking habits - -RSB- .
2543766	0	thymidine_kinase	42,58	TK	60,62	thymidine kinase	TK	1487380(Tax:10320)	1487380(Tax:10320)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of the bovine_herpesvirus_type_1 thymidine_kinase -LRB- TK -RRB- gene from wild-type virus and TK-deficient mutants .
12527796	0	thymidine_kinase	43,59	TK-2	61,65	thymidine kinase	TK-2	24271467	7084	Gene	Gene	inhibitors|nmod|START_ENTITY inhibitors|appos|END_ENTITY	Non-nucleoside inhibitors of mitochondrial thymidine_kinase -LRB- TK-2 -RRB- differentially inhibit the closely related herpes_simplex_virus_type_1 TK and Drosophila_melanogaster multifunctional deoxynucleoside kinase .
17322372	0	thymidine_kinase	52,68	TK2	70,73	thymidine kinase	TK2	57813(Tax:10090)	57813(Tax:10090)	Gene	Gene	overexpression|nmod|START_ENTITY overexpression|appos|END_ENTITY	Targeted transgenic overexpression of mitochondrial thymidine_kinase -LRB- TK2 -RRB- alters mitochondrial DNA -LRB- mtDNA -RRB- and mitochondrial polypeptide abundance : transgenic TK2 , mtDNA , and antiretrovirals .
23932787	0	thymidine_kinase	129,145	TK2	147,150	thymidine kinase	TK2	7084	7084	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular and clinical characterization of the myopathic form of mitochondrial_DNA_depletion_syndrome caused by mutations in the thymidine_kinase -LRB- TK2 -RRB- gene .
22143937	0	thymidine_kinase_1	5,23	TK1	25,28	thymidine kinase 1	TK1	7083	7083	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	High thymidine_kinase_1 -LRB- TK1 -RRB- expression is a predictor of poor survival in patients with pT1 of lung_adenocarcinoma .
11389691	0	thymidine_kinase_1	21,39	p21	45,48	thymidine kinase 1	p21	7083	1026	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of human thymidine_kinase_1 with p21 -LRB- Waf1 -RRB- .
12820387	0	thymidine_phosphorylase	12,35	TP	37,39	thymidine phosphorylase	TP	1890	1890	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of thymidine_phosphorylase -LRB- TP -RRB- mRNA expression in angiogenesis of prostate_cancer .
10810442	0	thymidine_phosphorylase	98,121	Vascular_endothelial_growth_factor	0,34	thymidine phosphorylase	Vascular endothelial growth factor	1890	7422	Gene	Gene	expression|amod|START_ENTITY correlation|nmod|expression expression|dep|correlation expression|amod|END_ENTITY	Vascular_endothelial_growth_factor expression in progression of cervical_cancer : correlation with thymidine_phosphorylase expression , angiogenesis , tumor cell proliferation , and apoptosis .
18630517	0	thymidine_phosphorylase	30,53	dihydropyrimidine_dehydrogenase	77,108	thymidine phosphorylase	dihydropyrimidine dehydrogenase	1890	1806	Gene	Gene	expression|nmod|START_ENTITY Changes|nmod|expression thymidylate_synthase|nsubj|Changes thymidylate_synthase|dep|END_ENTITY	Changes of gene expression of thymidine_phosphorylase , thymidylate_synthase , dihydropyrimidine_dehydrogenase after the administration of 5 ' - deoxy-5-fluorouridine , paclitaxel and its combination in human gastric_cancer xenografts .
21791367	0	thymidine_phosphorylase	55,78	dihydropyrimidine_dehydrogenase	22,53	thymidine phosphorylase	dihydropyrimidine dehydrogenase	1890	1806	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
21791367	0	thymidine_phosphorylase	55,78	orotate_phosphoribosyltransferase	80,113	thymidine phosphorylase	orotate phosphoribosyltransferase	1890	7372	Gene	Gene	expression|dep|START_ENTITY expression|dep|END_ENTITY	Thymidylate synthase , dihydropyrimidine_dehydrogenase , thymidine_phosphorylase , orotate_phosphoribosyltransferase mRNA expression in lung cancer metastatic lymph node samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration : a pilot study .
12118322	0	thymidine_phosphorylase	62,85	platelet-derived_endothelial_cell_growth_factor	14,61	thymidine phosphorylase	platelet-derived endothelial cell growth factor	1890	1890	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of platelet-derived_endothelial_cell_growth_factor / thymidine_phosphorylase in cervical_intraepithelial_neoplasia .
12644837	0	thymidine_phosphorylase	56,79	platelet-derived_endothelial_cell_growth_factor	8,55	thymidine phosphorylase	platelet-derived endothelial cell growth factor	1890	1890	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of platelet-derived_endothelial_cell_growth_factor / thymidine_phosphorylase in fluoropyrimidine sensitivity .
11061344	0	thymidine_phosphorylase	66,89	vascular_endothelial_growth_factor	27,61	thymidine phosphorylase	vascular endothelial growth factor	1890	7422	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Angiogenic interactions of vascular_endothelial_growth_factor , of thymidine_phosphorylase , and of p53 protein expression in locally advanced gastric_cancer .
23385749	0	thymidylate_kinase	99,117	TTHA1607	119,127	thymidylate kinase	TTHA1607	3169786(Tax:300852)	3169786(Tax:300852)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Cloning , expression , purification , crystallization and preliminary X-ray crystallographic study of thymidylate_kinase -LRB- TTHA1607 -RRB- from Thermus_thermophilus_HB8 .
10873110	0	thymidylate_synthase	14,34	TS	36,38	thymidylate synthase	TS	22171(Tax:10090)	22171(Tax:10090)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Comparison of thymidylate_synthase -LRB- TS -RRB- protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues .
15682292	0	thymidylate_synthase	48,68	TYMS	70,74	thymidylate synthase	TYMS	7298	7298	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common insertion/deletion polymorphism of the thymidylate_synthase -LRB- TYMS -RRB- gene is a determinant of red blood cell folate and homocysteine concentrations .
17018589	0	thymidylate_synthase	42,62	TYMS	64,68	thymidylate synthase	TYMS	7298	7298	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic copy number changes affecting the thymidylate_synthase -LRB- TYMS -RRB- gene in cancer : a model for patient classification to aid fluoropyrimidine therapy .
25762627	0	thymidylate_synthase	18,38	TYMS	40,44	thymidylate synthase	TYMS	7298	7298	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of thymidylate_synthase -LRB- TYMS -RRB- is associated with aggressive_tumor features and early PSA recurrence in prostate_cancer .
3339615	0	thymidylate_synthase	21,41	dihydrofolate_reductase	52,75	thymidylate synthase	dihydrofolate reductase	22171(Tax:10090)	1719	Gene	Gene	Inhibition|nmod|START_ENTITY END_ENTITY|nsubj|Inhibition	Inhibition of murine thymidylate_synthase and human dihydrofolate_reductase by 5,8-dideaza analogues of folic_acid and aminopterin .
9260894	0	thymidylate_synthase	20,40	p53	76,79	thymidylate synthase	p53	22171(Tax:10090)	22060(Tax:10090)	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Inhibition of mouse thymidylate_synthase promoter activity by the wild-type p53 tumor suppressor protein .
10360221	0	thymine-DNA_glycosylase	24,47	TDG	49,52	thymine-DNA glycosylase	TDG	6996	6996	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic analysis of the thymine-DNA_glycosylase -LRB- TDG -RRB- gene on 12q22-q24 .1 in human pancreatic_ductal_adenocarcinoma .
15569683	0	thymine_DNA_glycosylase	39,62	SUMO-1	12,18	thymine DNA glycosylase	SUMO-1	6996	7341	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Noncovalent SUMO-1 binding activity of thymine_DNA_glycosylase -LRB- TDG -RRB- is required for its SUMO-1 modification and colocalization with the promyelocytic_leukemia_protein .
15569683	0	thymine_DNA_glycosylase	39,62	SUMO-1	89,95	thymine DNA glycosylase	SUMO-1	6996	7341	Gene	Gene	activity|nmod|START_ENTITY required|nsubjpass|activity required|nmod|modification modification|compound|END_ENTITY	Noncovalent SUMO-1 binding activity of thymine_DNA_glycosylase -LRB- TDG -RRB- is required for its SUMO-1 modification and colocalization with the promyelocytic_leukemia_protein .
23165212	0	thymine_DNA_glycosylase	30,53	TDG	55,58	thymine DNA glycosylase	TDG	6996	6996	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of thymine_DNA_glycosylase -LRB- TDG -RRB- by the tumor suppressor protein p53 .
23165212	0	thymine_DNA_glycosylase	30,53	p53	92,95	thymine DNA glycosylase	p53	6996	7157	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of thymine_DNA_glycosylase -LRB- TDG -RRB- by the tumor suppressor protein p53 .
17984099	0	thymosin_beta4	29,43	Ku80	0,4	thymosin beta4	Ku80	7114	7520	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|nmod|receptor	Ku80 as a novel receptor for thymosin_beta4 that mediates its intracellular activity different from G-actin sequestering .
10623805	0	thymus-expressed_chemokine	38,64	CCR9	7,11	thymus-expressed chemokine	CCR9	20300(Tax:10090)	12769(Tax:10090)	Gene	Gene	receptor|nmod|START_ENTITY END_ENTITY|appos|receptor	Murine CCR9 , a chemokine receptor for thymus-expressed_chemokine that is up-regulated following pre-TCR signaling .
11046037	0	thymus-expressed_chemokine	12,38	CCR9	56,60	thymus-expressed chemokine	CCR9	6370	10803	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|nsubj|role	The role of thymus-expressed_chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system .
7737270	0	thymus-leukemia_antigen	54,77	TAP2	96,100	thymus-leukemia antigen	TAP2	15043(Tax:10090)	21355(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY independent|nsubj|expression independent|nmod|END_ENTITY	Surface expression of beta_2-microglobulin-associated thymus-leukemia_antigen is independent of TAP2 .
11642275	0	thymus_and_activation-regulated_chemokine	28,69	TARC	71,75	thymus and activation-regulated chemokine	TARC	403586(Tax:9615)	403586(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Molecular cloning of canine thymus_and_activation-regulated_chemokine -LRB- TARC -RRB- gene and its expression in various tissues .
12390321	0	thymus_and_activation-regulated_chemokine	19,60	TARC	62,66	thymus and activation-regulated chemokine	TARC	6361	6361	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Elevated levels of thymus_and_activation-regulated_chemokine -LRB- TARC -RRB- in pleural_effusion samples from patients infested with Paragonimus_westermani .
25219597	0	thymus_and_activation-regulated_chemokine	14,55	TARC	57,61	thymus and activation-regulated chemokine	TARC	6361	6361	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of thymus_and_activation-regulated_chemokine -LRB- TARC -RRB- by human dermal cells , but not epidermal keratinocytes .
2161422	0	thyroglobulin	46,59	Interferon-gamma	0,16	thyroglobulin	Interferon-gamma	7038	3458	Gene	Gene	transcription|compound|START_ENTITY inhibits|dobj|transcription inhibits|nsubj|END_ENTITY	Interferon-gamma inhibits thyrotropin-induced thyroglobulin gene transcription in cultured human thyrocytes .
2788696	0	thyroglobulin	50,63	Interleukin-1	0,13	thyroglobulin	Interleukin-1	7038	3552	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-1 inhibits thyrotrophin-induced human thyroglobulin gene expression .
15008249	0	thyroglobulin	9,22	RAP	137,140	thyroglobulin	RAP	24826(Tax:10116)	116565(Tax:10116)	Gene	Gene	START_ENTITY|dep|evidence evidence|nmod|role role|nmod|END_ENTITY	Impaired thyroglobulin -LRB- Tg -RRB- secretion by FRTL-5 cells transfected with soluble receptor associated protein -LRB- RAP -RRB- : evidence for a role of RAP in the Tg biosynthetic pathway .
3961413	0	thyroglobulin	13,26	TGL	28,31	thyroglobulin	TGL	7038	7038	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	The value of thyroglobulin -LRB- TGL -RRB- assay in following the post-therapeutic course of differentiated thyroid_cancer .
17495424	0	thyroglobulin	41,54	Tg	56,58	thyroglobulin	Tg	21819(Tax:10090)	21819(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	TGF-beta-like transcriptional effects of thyroglobulin -LRB- Tg -RRB- in mouse mesangial cells .
3082636	0	thyroglobulin	29,42	Tg	44,46	thyroglobulin	Tg	7038	7038	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Critical evaluation of serum thyroglobulin -LRB- Tg -RRB- levels during thyroid hormone suppression therapy versus Tg levels after hormone withdrawal and total_body_scan : results in 291 patients with thyroid_cancer .
1476872	0	thyroglobulin	16,29	platelet_activating_factor	51,77	thyroglobulin	platelet activating factor	7038	9768	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Effect of human thyroglobulin on the production of platelet_activating_factor from peripheral blood mononuclear cells from patients with autoimmune_thyroid_diseases .
17077133	0	thyroglobulin	11,24	thyroglobulin	115,128	thyroglobulin	thyroglobulin	7038	7038	Gene	Gene	has|nsubj|START_ENTITY has|nmod|END_ENTITY	Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human tsh-stimulated thyroglobulin in follow-up of thyroid_cancer patients .
17077133	0	thyroglobulin	115,128	thyroglobulin	11,24	thyroglobulin	thyroglobulin	7038	7038	Gene	Gene	has|nmod|START_ENTITY has|nsubj|END_ENTITY	Monitoring thyroglobulin in a sensitive immunoassay has comparable sensitivity to recombinant human tsh-stimulated thyroglobulin in follow-up of thyroid_cancer patients .
7711079	0	thyroid-specific_enhancer-binding_protein	46,87	T/EBP	89,94	thyroid-specific enhancer-binding protein	T/EBP	21869(Tax:10090)	21869(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The complete nucleotide sequence of the mouse thyroid-specific_enhancer-binding_protein -LRB- T/EBP -RRB- gene : extensive identity of the deduced amino_acid sequence with the human protein .
8779840	0	thyroid_hormone	36,51	SERCA_2	14,21	thyroid hormone	SERCA 2	396436(Tax:9031)	396446(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Regulation of SERCA_2 expression by thyroid_hormone in cultured chick embryo cardiomyocytes .
11811657	0	thyroid_hormone-responsive_protein	44,78	THRP	80,84	thyroid hormone-responsive protein	THRP	286928(Tax:10116)	286928(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	mRNA differential display identification of thyroid_hormone-responsive_protein -LRB- THRP -RRB- gene in association with early phase of long-term potentiation .
17872380	0	thyroid_hormone_receptor-alpha	4,34	TRalpha	36,43	thyroid hormone receptor-alpha	TRalpha	21833(Tax:10090)	14685(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The thyroid_hormone_receptor-alpha -LRB- TRalpha -RRB- gene encoding TRalpha1 controls deoxyribonucleic acid damage-induced tissue repair .
17872380	0	thyroid_hormone_receptor-alpha	4,34	TRalpha1	59,67	thyroid hormone receptor-alpha	TRalpha1	21833(Tax:10090)	21833(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|acl|encoding encoding|dobj|END_ENTITY	The thyroid_hormone_receptor-alpha -LRB- TRalpha -RRB- gene encoding TRalpha1 controls deoxyribonucleic acid damage-induced tissue repair .
24075770	0	thyroid_hormone_receptor-b	95,121	MGL-3196	68,76	thyroid hormone receptor-b	MGL-3196	7068	5853958(Tax:425265)	Gene	Gene	agonist|amod|START_ENTITY END_ENTITY|appos|agonist	Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196 , a liver-targeted thyroid_hormone_receptor-b agonist .
19725132	0	thyroid_hormone_receptor_beta	116,145	THRB	147,151	thyroid hormone receptor beta	THRB	7068	7068	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Multiple genomic aberrations in a patient with mental_retardation and hypogonadism : 45 , X/46 , X , psu dic -LRB- Y -RRB- karyotype , thyroid_hormone_receptor_beta -LRB- THRB -RRB- mutation and heterozygosity for Wilson_disease .
23806029	0	thyroid_hormone_receptor_beta	31,60	THRB	62,66	thyroid hormone receptor beta	THRB	7068	7068	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Incidental identification of a thyroid_hormone_receptor_beta -LRB- THRB -RRB- gene variant in a family with autoimmune_thyroid_disease .
25302749	0	thyroid_hormone_receptor_beta	59,88	THRb	90,94	thyroid hormone receptor beta	THRb	7068	7068	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between promoter methylation and expression of thyroid_hormone_receptor_beta -LRB- THRb -RRB- gene in patients with gastric_cancer in an Iranian population .
12698219	0	thyroid_hormone_responsive_protein	10,44	THRP	46,50	thyroid hormone responsive protein	THRP	286928(Tax:10116)	286928(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of thyroid_hormone_responsive_protein -LRB- THRP -RRB- expression on PC12 cell survival .
9630690	0	thyroid_hormone_responsive_protein	23,57	THRP	59,63	thyroid hormone responsive protein	THRP	286928(Tax:10116)	286928(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Age-related changes in thyroid_hormone_responsive_protein -LRB- THRP -RRB- expression in cerebral tissue of rats .
17012164	0	thyroid_hormone_responsive_spot_14	51,85	THRSP	87,92	thyroid hormone responsive spot 14	THRSP	101800066	101800066	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Molecular cloning and expression of the duplicated thyroid_hormone_responsive_spot_14 -LRB- THRSP -RRB- genes in ducks .
19273419	0	thyroid_hormone_responsive_spot_14	15,49	THRSP	51,56	thyroid hormone responsive spot 14	THRSP	404755(Tax:9031)	404755(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	-LSB- Progresses on thyroid_hormone_responsive_spot_14 -LRB- THRSP -RRB- gene in chickens and ducks -RSB- .
17121535	0	thyroid_oxidase_2	57,74	THOX2	76,81	thyroid oxidase 2	THOX2	50506	50506	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Congenital_hypothyroidism caused by new mutations in the thyroid_oxidase_2 -LRB- THOX2 -RRB- gene .
10323395	0	thyroid_peroxidase	9,27	TPO	51,54	thyroid peroxidase	TPO	22018(Tax:10090)	22018(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Cellular thyroid_peroxidase -LRB- TPO -RRB- , unlike purified TPO and adjuvant , induces antibodies in mice that resemble autoantibodies in human autoimmune_thyroid_disease .
17381485	0	thyroid_peroxidase	90,108	TPO	110,113	thyroid peroxidase	TPO	7173	7173	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Clinical and genetic characteristics of congenital_hypothyroidism due to mutations in the thyroid_peroxidase -LRB- TPO -RRB- gene in Israelis .
19243353	0	thyroid_peroxidase	33,51	TPO	53,56	thyroid peroxidase	TPO	7173	7173	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two novel mutations in the human thyroid_peroxidase -LRB- TPO -RRB- gene : genetics and clinical findings in four children .
23223904	0	thyroid_peroxidase	2,20	TPO	22,25	thyroid peroxidase	TPO	403521(Tax:9615)	403521(Tax:9615)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A thyroid_peroxidase -LRB- TPO -RRB- mutation in dogs reveals a canid-specific gene structure .
24420335	0	thyroid_peroxidase	20,38	TPO	40,43	thyroid peroxidase	TPO	7173	7173	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic analysis of thyroid_peroxidase -LRB- TPO -RRB- gene in patients whose hypothyroidism was found in adulthood in West Bengal , India .
24482635	0	thyroid_peroxidase	50,68	TPO	70,73	thyroid peroxidase	TPO	7173	7173	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	Detection of heterozygous c. 1708C > T and c. 1978C > G thyroid_peroxidase -LRB- TPO -RRB- mutations in Iraqi patients with toxic and nontoxic_goiter .
8440133	0	thyroid_peroxidase	38,56	TPO	63,66	thyroid peroxidase	TPO	7173	7173	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regional sublocalization of the human thyroid_peroxidase gene -LRB- TPO -RRB- by tritium and fluorescence in situ hybridization to chromosome 2p25 -- > p24 .
17204413	0	thyroid_peroxidase	53,71	TPOX	73,77	thyroid peroxidase	TPOX	7173	7173	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Determination of microsatellite repeats in the human thyroid_peroxidase -LRB- TPOX -RRB- gene using an automated gene analysis system with nanoscale engineered biomagnetite .
2369842	0	thyroid_stimulating_hormone_beta_subunit	42,82	TSHB	84,88	thyroid stimulating hormone beta subunit	TSHB	7252	7252	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosome regional mapping for the human thyroid_stimulating_hormone_beta_subunit -LRB- TSHB -RRB- gene .
2249847	0	thyroid_stimulating_hormone_receptor	24,60	TSHR	62,66	thyroid stimulating hormone receptor	TSHR	7253	7253	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the human thyroid_stimulating_hormone_receptor -LRB- TSHR -RRB- gene to chromosome 14q31 .
11713256	0	thyroid_transcription_factor-1	110,140	CBP/p300	8,16	thyroid transcription factor-1	CBP/p300	7080	1387;2033	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary_surfactant_protein-A -LRB- SP-A -RRB- gene by thyroid_transcription_factor-1 -LRB- TTF-1 -RRB- .
9988700	0	thyroid_transcription_factor-1	54,84	Calreticulin	0,12	thyroid transcription factor-1	Calreticulin	7080	811	Gene	Gene	activity|nmod|START_ENTITY enhances|dobj|activity enhances|nsubj|END_ENTITY	Calreticulin enhances the transcriptional activity of thyroid_transcription_factor-1 by binding to its homeodomain .
9915795	0	thyroid_transcription_factor-1	34,64	GATA-6	0,6	thyroid transcription factor-1	GATA-6	7080	2627	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	GATA-6 activates transcription of thyroid_transcription_factor-1 .
11584016	0	thyroid_transcription_factor-1	43,73	Nestin	0,6	thyroid transcription factor-1	Nestin	21869(Tax:10090)	18008(Tax:10090)	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Nestin is a neuroepithelial target gene of thyroid_transcription_factor-1 , a homeoprotein required for forebrain organogenesis .
12882447	0	thyroid_transcription_factor-1	15,45	TAP26	66,71	thyroid transcription factor-1	TAP26	7080	29080	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	BR22 , a 26 kDa thyroid_transcription_factor-1 associated protein -LRB- TAP26 -RRB- , is expressed in human lung cells .
24901475	0	thyroid_transcription_factor-1	42,72	cytokeratin_20	8,22	thyroid transcription factor-1	cytokeratin 20	7080	54474	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Loss of cytokeratin_20 and acquisition of thyroid_transcription_factor-1 expression in a merkel cell carcinoma metastasis to the brain .
12051626	0	thyroid_transcription_factor-1	111,141	thyroid_transcription_factor-1	29,59	thyroid transcription factor-1	thyroid transcription factor-1	7080	7080	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|dep|expression	Immunohistochemical study of thyroid_transcription_factor-1 and HER2/neu in non-small_cell_lung_cancer : strong thyroid_transcription_factor-1 expression predicts better survival .
12051626	0	thyroid_transcription_factor-1	29,59	thyroid_transcription_factor-1	111,141	thyroid transcription factor-1	thyroid transcription factor-1	7080	7080	Gene	Gene	START_ENTITY|dep|expression expression|amod|END_ENTITY	Immunohistochemical study of thyroid_transcription_factor-1 and HER2/neu in non-small_cell_lung_cancer : strong thyroid_transcription_factor-1 expression predicts better survival .
25489257	0	thyroid_transcription_factor_1	16,46	EGFR	50,54	thyroid transcription factor 1	EGFR	7080	1956	Gene	Gene	START_ENTITY|nmod|status status|amod|END_ENTITY	Relationship of thyroid_transcription_factor_1 to EGFR status in non-small-cell_lung_cancer .
23625920	0	thyroid_transcription_factor_1	86,116	MicroRNA-33a	0,12	thyroid transcription factor 1	MicroRNA-33a	7080	407039	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	MicroRNA-33a mediates the regulation of high_mobility_group_AT-hook_2 gene -LRB- HMGA2 -RRB- by thyroid_transcription_factor_1 -LRB- TTF-1 / NKX2-1 -RRB- .
11834746	0	thyroid_transcription_factor_1	50,80	Redox_effector_factor-1	0,23	thyroid transcription factor 1	Redox effector factor-1	7080	328	Gene	Gene	activity|nmod|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	Redox_effector_factor-1 regulates the activity of thyroid_transcription_factor_1 by controlling the redox state of the N transcriptional activation domain .
10403172	0	thyroid_transcription_factor_2	83,113	TITF2	120,125	thyroid transcription factor 2	TITF2	2304	2304	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning , chromosomal localization and identification of polymorphisms in the human thyroid_transcription_factor_2 gene -LRB- TITF2 -RRB- .
3920581	0	thyroliberin	25,37	TRH	39,42	thyroliberin	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	Developmental changes of thyroliberin -LRB- TRH -RRB- in the rat brain .
10698171	0	thyroperoxidase	43,58	Calnexin	0,8	thyroperoxidase	Calnexin	7173	821	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Calnexin and calreticulin binding to human thyroperoxidase is required for its first folding step -LRB- s -RRB- but is not sufficient to promote efficient cell surface expression .
10924503	0	thyroperoxidase	36,51	Pax_8	17,22	thyroperoxidase	Pax 8	7173	7849	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Role for p300 in Pax_8 induction of thyroperoxidase gene expression .
10924503	0	thyroperoxidase	36,51	p300	9,13	thyroperoxidase	p300	7173	2033	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression END_ENTITY|nmod|induction	Role for p300 in Pax_8 induction of thyroperoxidase gene expression .
6774889	0	thyrotrophic-releasing_hormone	11,41	TRH	43,46	thyrotrophic-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of thyrotrophic-releasing_hormone -LRB- TRH -RRB- on thermoregulation in the rat .
6131565	0	thyrotrophin-releasing_hormone	14,44	TRH	46,49	thyrotrophin-releasing hormone	TRH	7200	7200	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of thyrotrophin-releasing_hormone -LRB- TRH -RRB- on pancreatic hormone secretion in normal subjects .
6404539	0	thyrotrophin-releasing_hormone	22,52	TRH	54,57	thyrotrophin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Stimulatory effect of thyrotrophin-releasing_hormone -LRB- TRH -RRB- on the release of luteinizing hormone -LRB- LH -RRB- from rat anterior pituitary cells in vitro .
8781630	0	thyrotrophin-releasing_hormone	27,57	TRH	59,62	thyrotrophin-releasing hormone	TRH	7200	7200	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of lithium and oral thyrotrophin-releasing_hormone -LRB- TRH -RRB- on serum thyrotrophin -LRB- TSH -RRB- and radioiodine uptake in patients with well differentiated thyroid_carcinoma .
3923149	0	thyrotrophin-releasing_hormone	53,83	growth_hormone	25,39	thyrotrophin-releasing hormone	growth hormone	101122470	443329(Tax:9940)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|control control|nmod|END_ENTITY	Physiological control of growth_hormone secretion by thyrotrophin-releasing_hormone in the domestic fowl .
3918138	0	thyrotrophin-releasing_hormone	24,54	prolactin	87,96	thyrotrophin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|nmod|concentrations concentrations|nmod|END_ENTITY	Effects of antiserum to thyrotrophin-releasing_hormone on the concentrations of plasma prolactin , thyrotrophin and LH in the pro-oestrous rat .
6784427	0	thyrotrophin-releasing_hormone	46,76	prolactin	6,15	thyrotrophin-releasing hormone	prolactin	7200	5617	Gene	Gene	Serum|xcomp|START_ENTITY Serum|dobj|responses responses|compound|END_ENTITY	Serum prolactin and thyrotrophin responses to thyrotrophin-releasing_hormone at different times of the day in normal women .
5935575	0	thyrotropic_hormone-releasing_factor	12,48	TRF	50,53	thyrotropic hormone-releasing factor	TRF	7200	7200	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of thyrotropic_hormone-releasing_factor -LRB- TRF -RRB- in porcine hypothalamus .
3930271	0	thyrotropin-releasing-hormone	38,67	Prolactin	0,9	thyrotropin-releasing-hormone	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin and thyrotropin response to thyrotropin-releasing-hormone in adolescent females with insulin-treated diabetes_mellitus .
4209106	0	thyrotropin-releasing_factor	16,44	TRF	46,49	thyrotropin-releasing factor	TRF	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of thyrotropin-releasing_factor -LRB- TRF -RRB- in the hypothalamus of the rat .
3106117	0	thyrotropin-releasing_factor	19,47	TRH	49,52	thyrotropin-releasing factor	TRH	7200	7200	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Biphasic effect of thyrotropin-releasing_factor -LRB- TRH -RRB- on alpha-melanotropin secretion from frog intermediate lobe in vitro .
16337947	0	thyrotropin-releasing_factor	45,73	corticotropin-releasing_hormone	8,39	thyrotropin-releasing factor	corticotropin-releasing hormone	7200	1392	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of corticotropin-releasing_hormone as a thyrotropin-releasing_factor in non-mammalian vertebrates .
2907311	0	thyrotropin-releasing_factor	88,116	growth_hormone	120,134	thyrotropin-releasing factor	growth hormone	7200	2688	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Synergism and diurnal variations of human growth_hormone-releasing factor -LRB- 1-29 -RRB- NH2 and thyrotropin-releasing_factor on growth_hormone release in dairy calves .
18041110	0	thyrotropin-releasing_hormone	18,47	Ca2	0,3	thyrotropin-releasing hormone	Ca2	7200	760	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Ca2 + responses to thyrotropin-releasing_hormone and angiotensin_II : the role of plasma membrane integrity and effect of G11alpha protein overexpression on homologous and heterologous desensitization .
16603724	0	thyrotropin-releasing_hormone	79,108	EGF_receptor	27,39	thyrotropin-releasing hormone	EGF receptor	22044(Tax:10090)	13649(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|mechanism mechanism|nmod|END_ENTITY	The molecular mechanism of EGF_receptor activation in pancreatic beta-cells by thyrotropin-releasing_hormone .
19446581	0	thyrotropin-releasing_hormone	24,53	Follistatin	0,11	thyrotropin-releasing hormone	Follistatin	25569(Tax:10116)	24373(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Follistatin , induced by thyrotropin-releasing_hormone -LRB- TRH -RRB- , plays no role in prolactin expression but affects gonadotropin FSHbeta expression as a paracrine factor in pituitary somatolactotroph GH3 cells .
14551231	0	thyrotropin-releasing_hormone	91,120	GH	51,53	thyrotropin-releasing hormone	GH	100346454(Tax:9986)	100356068(Tax:9986)	Gene	Gene	effects|amod|START_ENTITY effects|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Endocrine and metabolic effects of growth_hormone -LRB- GH -RRB- compared with GH-releasing peptide , thyrotropin-releasing_hormone , and insulin infusion in a rabbit model of prolonged critical_illness .
1624675	0	thyrotropin-releasing_hormone	182,211	GH	23,25	thyrotropin-releasing hormone	GH	7200	2688	Gene	Gene	corticotropin-releasing_hormone|nmod|START_ENTITY growth_hormone|advcl|corticotropin-releasing_hormone growth_hormone|dobj|responses responses|appos|END_ENTITY	Plasma growth_hormone -LRB- GH -RRB- responses to corticotropin-releasing_hormone in patients with acromegaly -- the effect of dexamethasone pretreatment and the comparison with GH responses to thyrotropin-releasing_hormone , gonadotropin-releasing_hormone and GH-releasing_hormone .
2512341	0	thyrotropin-releasing_hormone	51,80	GH	44,46	thyrotropin-releasing hormone	GH	7200	2688	Gene	Gene	growth_hormone|acl|START_ENTITY growth_hormone|appos|END_ENTITY	The paradoxical response of growth_hormone -LRB- GH -RRB- to thyrotropin-releasing_hormone -LRB- TRH -RRB- in constitutionally tall children involves a cholinergic pathway .
3108068	0	thyrotropin-releasing_hormone	93,122	GH	160,162	thyrotropin-releasing hormone	GH	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|appos|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
3917270	0	thyrotropin-releasing_hormone	126,155	GH	27,29	thyrotropin-releasing hormone	GH	7200	2688	Gene	Gene	comparison|nmod|START_ENTITY Changes|dep|comparison Changes|nmod|secretion secretion|appos|END_ENTITY	Changes in growth_hormone -LRB- GH -RRB- secretion induced by human pancreatic GH releasing hormone-44 in acromegaly : a comparison with thyrotropin-releasing_hormone and bromocriptine .
3923021	0	thyrotropin-releasing_hormone	82,111	GH	162,164	thyrotropin-releasing hormone	GH	7200	2688	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|growth_hormone growth_hormone|appos|END_ENTITY	Different responses of growth_hormone secretion to guanfacine , bromocriptine , and thyrotropin-releasing_hormone in acromegalic patients with pure growth_hormone -LRB- GH -RRB- - containing and mixed GH/prolactin-containing pituitary_adenomas .
7991070	0	thyrotropin-releasing_hormone	205,234	GH	140,142	thyrotropin-releasing hormone	GH	7200	2688	Gene	Gene	responses|nmod|START_ENTITY comparison|nmod|responses Lack|dep|comparison Lack|nmod|involvement involvement|nmod|mechanism mechanism|nmod|responses responses|appos|END_ENTITY	Lack of involvement of the cholinergic mechanism in vasoactive intestinal peptide - and peptide-histidine_methionine-induced growth_hormone -LRB- GH -RRB- responses in acromegaly : comparison with the GH responses to thyrotropin-releasing_hormone and GH-releasing_hormone .
7991070	0	thyrotropin-releasing_hormone	205,234	GH	189,191	thyrotropin-releasing hormone	GH	7200	2688	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Lack of involvement of the cholinergic mechanism in vasoactive intestinal peptide - and peptide-histidine_methionine-induced growth_hormone -LRB- GH -RRB- responses in acromegaly : comparison with the GH responses to thyrotropin-releasing_hormone and GH-releasing_hormone .
1398470	0	thyrotropin-releasing_hormone	27,56	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	7200	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in acromegalic patients : reproducibility and dose-response study .
3096046	0	thyrotropin-releasing_hormone	27,56	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	7200	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in children and adolescents : a reappraisal .
3135504	0	thyrotropin-releasing_hormone	36,65	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	induced|nmod|START_ENTITY secretion|acl|induced secretion|amod|END_ENTITY	Growth_hormone secretion induced by thyrotropin-releasing_hormone in adult chickens : evidence of dose-dependent induction of either refractoriness or sensitization .
3924582	0	thyrotropin-releasing_hormone	27,56	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in the urethane-anesthetized rat : effect of thyroid status .
404131	0	thyrotropin-releasing_hormone	37,66	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY releasing|dobj|activity END_ENTITY|xcomp|releasing	Growth_hormone releasing activity of thyrotropin-releasing_hormone in rats with hypothalamic_lesions .
6128295	0	thyrotropin-releasing_hormone	27,56	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	7200	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone in liver cirrhosis : unique alteration in anterior pituitary responsiveness to hypothalamic hormones .
6401755	0	thyrotropin-releasing_hormone	27,56	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	7200	2688	Gene	Gene	tests|amod|START_ENTITY END_ENTITY|nmod|tests	Growth_hormone response to thyrotropin-releasing_hormone and oral glucose-loading tests in tall children and adolescents .
6769068	0	thyrotropin-releasing_hormone	27,56	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	7200	2688	Gene	Gene	stimulation|amod|START_ENTITY response|nmod|stimulation response|amod|END_ENTITY	Growth_hormone response to thyrotropin-releasing_hormone and gonadotropin-releasing_hormone stimulation in heroin addicts .
6780591	0	thyrotropin-releasing_hormone	80,109	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	7200	2688	Gene	Gene	determinant|acl|START_ENTITY determinant|nsubj|status status|amod|END_ENTITY	Growth_hormone secretory status is a determinant of the thyrotropin response to thyrotropin-releasing_hormone in euthyroid patients with hypothalamic-pituitary_disease .
803976	0	thyrotropin-releasing_hormone	56,85	Growth_hormone	0,14	thyrotropin-releasing hormone	Growth hormone	7200	2688	Gene	Gene	injection|nmod|START_ENTITY release|nmod|injection release|nsubj|END_ENTITY	Growth_hormone and prolactin release after injection of thyrotropin-releasing_hormone in patients with depression .
117409	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in normal and complicated late pregnancies .
12244566	0	thyrotropin-releasing_hormone	99,128	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	stimulated|nmod|START_ENTITY subpopulations|acl|stimulated change|nmod|subpopulations change|nsubj|secretion secretion|compound|END_ENTITY	Prolactin secretion and intracellular Ca -LRB- 2 + -RRB- change in rat lactotroph subpopulations stimulated by thyrotropin-releasing_hormone .
16484326	0	thyrotropin-releasing_hormone	33,62	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	22044(Tax:10090)	19109(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY mice|nmod|deficiency secretion|nmod|mice secretion|nsubj|END_ENTITY	Prolactin secretion in mice with thyrotropin-releasing_hormone deficiency .
1906673	0	thyrotropin-releasing_hormone	23,52	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin responses to thyrotropin-releasing_hormone in multi-infarct_dementia and senile_dementia of the Alzheimer_type .
3094215	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in early and advanced human breast_cancer .
3106094	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	response|xcomp|START_ENTITY response|nsubj|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in women with infertility and/or randomly elevated serum prolactin levels .
3917409	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with hypothalamic-pituitary_disease .
3922866	0	thyrotropin-releasing_hormone	38,67	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin and thyrotropin response to thyrotropin-releasing_hormone in premenopausal women with fibrocystic_disease of the breast .
6233752	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in children with gynecomastia , premature_thelarche and idiopathic_precocious_puberty .
6420042	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	stimulation|amod|START_ENTITY response|nmod|stimulation response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone stimulation and dopaminergic inhibition in benign_breast_disease .
6425749	0	thyrotropin-releasing_hormone	39,68	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone during the peripartal period .
6434573	0	thyrotropin-releasing_hormone	39,68	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone and metoclopramide in men with chronic alcoholism .
6807677	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone in children with Turner 's _ syndrome and hyperthyroidism .
6811338	0	thyrotropin-releasing_hormone	42,71	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	hyperstimulation|xcomp|START_ENTITY hyperstimulation|nsubj|END_ENTITY	Prolactin hyperstimulation in response to thyrotropin-releasing_hormone in patients with endometriosis .
819453	0	thyrotropin-releasing_hormone	39,68	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Prolactin and thyrotropin responses to thyrotropin-releasing_hormone in patients with secondary amenorrhea : the effect of bromocriptine .
9433398	0	thyrotropin-releasing_hormone	22,51	Prolactin	0,9	thyrotropin-releasing hormone	Prolactin	7200	5617	Gene	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	Prolactin response to thyrotropin-releasing_hormone as a guideline for cyclical mastalgia treatment .
11738621	0	thyrotropin-releasing_hormone	29,58	TRH	60,63	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis and biology of new thyrotropin-releasing_hormone -LRB- TRH -RRB- analogues .
117895	0	thyrotropin-releasing_hormone	36,65	TRH	67,70	thyrotropin releasing hormone	TRH	7200	7200	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of thyrotropin-releasing_hormone -LRB- TRH -RRB- in skin of Rana pipiens .
12124766	0	thyrotropin-releasing_hormone	16,45	TRH	47,50	thyrotropin-releasing hormone	TRH	266721(Tax:7955)	266721(Tax:7955)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- immunoreactivity in the brain of the zebrafish -LRB- Danio_rerio -RRB- .
12697690	0	thyrotropin-releasing_hormone	27,56	TRH	58,61	thyrotropin-releasing hormone	TRH	397780(Tax:8355)	397780(Tax:8355)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Pharmacological studies of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors from Xenopus_laevis : is xTRHR3 a TRH_receptor ?
1324930	0	thyrotropin-releasing_hormone	14,43	TRH	45,48	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation by thyrotropin-releasing_hormone -LRB- TRH -RRB- of TRH_receptor mRNA degradation in rat pituitary GH3 cells .
1359733	0	thyrotropin-releasing_hormone	56,85	TRH	87,90	thyrotropin-releasing hormone	TRH	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Adrenergic and non-adrenergic cardiovascular effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- in the anaesthetized rabbit .
1370611	0	thyrotropin-releasing_hormone	13,42	TRH	44,47	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Detection of thyrotropin-releasing_hormone -LRB- TRH -RRB- mRNA by the reverse transcription-polymerase chain reaction in the human normal and tumoral anterior pituitary .
1526263	0	thyrotropin-releasing_hormone	24,53	TRH	55,58	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Time-related effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the pituitary-thyroid_axis and extrathyroidal targets .
1651844	0	thyrotropin-releasing_hormone	55,84	TRH	86,89	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Epidermal_growth_factor decreases the concentration of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors and TRH responses in pituitary GH4C1 cells .
17474321	0	thyrotropin-releasing_hormone	13,42	TRH	44,47	thyrotropin-releasing hormone	TRH	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of thyrotropin-releasing_hormone -LRB- TRH -RRB- dialyzed into the hippocampus on memory processes in rabbit .
1803344	0	thyrotropin-releasing_hormone	30,59	TRH	61,64	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The cardiovascular effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- are attenuated by cimetidine in rats .
18382103	0	thyrotropin-releasing_hormone	16,45	TRH	47,50	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- immunoreactivity in the brain of urodele amphibians .
1850699	0	thyrotropin-releasing_hormone	19,48	TRH	50,53	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Down-regulation of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in spinal cord after transection as revealed by quantitative autoradiography .
18744	0	thyrotropin-releasing_hormone	43,72	TRH	74,77	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Lack of effect of chronically administered thyrotropin-releasing_hormone -LRB- TRH -RRB- on regional rat brain tyrosine_hydroxylase activity .
2108785	0	thyrotropin-releasing_hormone	22,51	TRH	53,56	thyrotropin-releasing hormone	TRH	100717613	100717613	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Excitatory effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- in hypoglossal motoneurons .
2112792	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on motor performance of hemiparetic_stroke patients .
2113675	0	thyrotropin-releasing_hormone	69,98	TRH	100,103	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	The effect of repeated administration of antidepressant drugs on the thyrotropin-releasing_hormone -LRB- TRH -RRB- content of rat brain structures .
2119425	0	thyrotropin-releasing_hormone	11,40	TRH	42,45	thyrotropin-releasing hormone	TRH	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on EEG topography -RSB- .
2124333	0	thyrotropin-releasing_hormone	34,63	TRH	65,68	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	The effect of fenfluramine on the thyrotropin-releasing_hormone -LRB- TRH -RRB- content in the rat brain structures and lumbar spinal cord .
2124486	0	thyrotropin-releasing_hormone	42,71	TRH	73,76	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Ca2 -LRB- + -RRB- - independent secretory mechanism of thyrotropin-releasing_hormone -LRB- TRH -RRB- involves protein_kinase_C in rat pituitary cells .
2156726	0	thyrotropin-releasing_hormone	17,46	TRH	48,51	thyrotropin-releasing hormone	TRH	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in brain thyrotropin-releasing_hormone -LRB- TRH -RRB- of seizure-prone El mice .
23000398	0	thyrotropin-releasing_hormone	37,66	TRH	68,71	thyrotropin-releasing hormone	TRH	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Family members CREB and CREM control thyrotropin-releasing_hormone -LRB- TRH -RRB- expression in the hypothalamus .
231172	0	thyrotropin-releasing_hormone	24,53	TRH	55,58	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	The direct influence of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the smooth muscle of rat duodenum .
24923830	0	thyrotropin-releasing_hormone	23,52	TRH	54,57	thyrotropin-releasing hormone	TRH	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Hypothalamic levels of thyrotropin-releasing_hormone -LRB- TRH -RRB- in male albino mice of different social status .
2501498	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the chemiluminescence -LRB- CL -RRB- activity of human mononuclear cells .
26216015	0	thyrotropin-releasing_hormone	24,53	TRH	55,58	thyrotropin-releasing hormone	TRH	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of CNS active thyrotropin-releasing_hormone -LRB- TRH -RRB- - like peptides : Biological evaluation and effect on cognitive_impairment induced by cerebral_ischemia in mice .
2834594	0	thyrotropin-releasing_hormone	17,46	TRH	48,51	thyrotropin-releasing hormone	TRH	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in brain thyrotropin-releasing_hormone -LRB- TRH -RRB- of El mice .
2864309	0	thyrotropin-releasing_hormone	44,73	TRH	75,78	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Correlative studies between the presence of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors and the in vitro stimulation of growth-hormone -LRB- GH -RRB- secretion in human GH-secreting adenomas .
2983260	0	thyrotropin-releasing_hormone	33,62	TRH	64,67	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Autoradiographic localization of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in human spinal cord .
2986203	0	thyrotropin-releasing_hormone	17,46	TRH	48,51	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Up-regulation of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in rat spinal cord after codepletion of serotonin and TRH .
3001843	0	thyrotropin-releasing_hormone	15,44	TRH	46,49	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of thyrotropin-releasing_hormone -LRB- TRH -RRB- neural system of the brain in pentylenetetrazol-induced seizures .
3085285	0	thyrotropin-releasing_hormone	29,58	TRH	60,63	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Acute and chronic effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on stabilogram in spinocerebellar_degenerations .
3098925	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Action|nmod|START_ENTITY Action|appos|END_ENTITY	Action of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the occurrence of fibrillation potentials and miniature end-plate potentials -LRB- MEPPs -RRB- .
3126225	0	thyrotropin-releasing_hormone	16,45	TRH	47,50	thyrotropin-releasing hormone	TRH	100717613	100717613	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- immunoreactivity in the thoracic spinal cord of guinea_pig .
3934717	0	thyrotropin-releasing_hormone	45,74	TRH	76,79	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Intraventricular 6-hydroxydopamine increases thyrotropin-releasing_hormone -LRB- TRH -RRB- content in regions of rat brain .
401667	0	thyrotropin-releasing_hormone	28,57	TRH	59,62	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Subcellular distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- in rat brain and hypothalamus .
4977749	0	thyrotropin-releasing_hormone	15,44	TRH	46,49	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Studies on the thyrotropin-releasing_hormone -LRB- TRH -RRB- activity in peripheral blood .
6104604	0	thyrotropin-releasing_hormone	11,40	TRH	42,45	thyrotropin-releasing hormone	TRH	100717613	100717613	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the isolated small intestine and taenia coli of the guinea_pig .
6322932	0	thyrotropin-releasing_hormone	16,45	TRH	47,50	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Localization of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in the septal nucleus of the rat brain .
6414881	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the synthesis and secretion of polysaccharides by the integument of gastropods .
6427443	0	thyrotropin-releasing_hormone	14,43	TRH	73,76	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	START_ENTITY|nmod|administration administration|nmod|END_ENTITY	Absorption of thyrotropin-releasing_hormone after oral administration of TRH tartrate monohydrate in the rat , dog and human .
6435101	0	thyrotropin-releasing_hormone	20,49	TRH	51,54	thyrotropin-releasing hormone	TRH	702455(Tax:9544)	702455(Tax:9544)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- in the rhesus_monkey spinal cord .
6778968	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on local cerebral glucose utilization , by the autoradiographic 2-deoxy -LSB- 14C -RSB- glucose method , in conscious and pentobarbitalized rats .
6801738	0	thyrotropin-releasing_hormone	22,51	TRH	53,56	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Seasonal variation in thyrotropin-releasing_hormone -LRB- TRH -RRB- content of different brain regions and the pineal in the mammalian hibernator , Citellus lateralis .
7805643	0	thyrotropin-releasing_hormone	14,43	TRH	45,48	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on limbic status_epilepticus in rats .
7884045	0	thyrotropin-releasing_hormone	16,45	TRH	47,50	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- - containing cells and fibers in the human hypothalamus .
805438	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	613414(Tax:9913)	613414(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on bovine plasma thyroxine levels at 18.5 and 35 C. Six mature nonlactating Holstein cows were subjected to a test procedure of a sham period -LRB- saline injection -RRB- of 10 days that prededed and followed each 14 day TRH treatment period at 18.5 and 35 degrees .
805836	0	thyrotropin-releasing_hormone	11,40	TRH	42,45	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of thyrotropin-releasing_hormone -LRB- TRH -RRB- on the actions of pentobarbital and other centrally acting drugs .
806923	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	613414(Tax:9913)	613414(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on plasma glucocorticoids and thyroxine in cattle .
8282969	0	thyrotropin-releasing_hormone	29,58	TRH	60,63	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Neuroendocrine regulation of thyrotropin-releasing_hormone -LRB- TRH -RRB- in the tuberoinfundibular system .
8294406	0	thyrotropin-releasing_hormone	32,61	TRH	63,66	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	interaction|nmod|START_ENTITY interaction|appos|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
8301363	0	thyrotropin-releasing_hormone	31,60	TRH	62,65	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Early postnatal development of thyrotropin-releasing_hormone -LRB- TRH -RRB- expression , TRH receptor binding , and TRH responses in neurons of rat brainstem .
8956461	0	thyrotropin-releasing_hormone	10,39	TRH	41,44	thyrotropin-releasing hormone	TRH	7200	7200	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- on cerebral blood flow in spinocerebellar_degeneration and cerebrovascular_disease .
8976533	0	thyrotropin-releasing_hormone	36,65	TRH	67,70	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Differential effects of intrathecal thyrotropin-releasing_hormone -LRB- TRH -RRB- on perineal reflexes in male rats .
9013814	0	thyrotropin-releasing_hormone	16,45	TRH	47,50	thyrotropin-releasing hormone	TRH	22044(Tax:10090)	22044(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Distribution of thyrotropin-releasing_hormone -LRB- TRH -RRB- receptors in the brain of the ataxic mutant mouse , rolling mouse Nagoya .
9225129	0	thyrotropin-releasing_hormone	28,57	TRH	59,62	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Serotonin -LRB- 5-HT -RRB- stimulates thyrotropin-releasing_hormone -LRB- TRH -RRB- gene transcription in rat embryonic cardiomyocytes .
9421422	0	thyrotropin-releasing_hormone	18,47	TRH	49,52	thyrotropin-releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of rat thyrotropin-releasing_hormone -LRB- TRH -RRB- gene in TRH-producing tissues of transgenic_mice requires sequences located in exon 1 .
1324930	0	thyrotropin-releasing_hormone	14,43	TRH_receptor	53,65	thyrotropin-releasing hormone	TRH receptor	25569(Tax:10116)	25570(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|degradation degradation|compound|END_ENTITY	Regulation by thyrotropin-releasing_hormone -LRB- TRH -RRB- of TRH_receptor mRNA degradation in rat pituitary GH3 cells .
8294406	0	thyrotropin-releasing_hormone	32,61	TRH_receptor	107,119	thyrotropin-releasing hormone	TRH receptor	7200	7201	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Hydrogen bonding interaction of thyrotropin-releasing_hormone -LRB- TRH -RRB- with transmembrane_tyrosine 106 of the TRH_receptor .
3123067	0	thyrotropin-releasing_hormone	55,84	Thyroid-stimulating_hormone_and_prolactin	0,41	thyrotropin-releasing hormone	Thyroid-stimulating hormone and prolactin	7200	5617	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Thyroid-stimulating_hormone_and_prolactin responses to thyrotropin-releasing_hormone in common migraine .
6401174	0	thyrotropin-releasing_hormone	183,212	alpha_MSH	162,171	thyrotropin-releasing hormone	alpha MSH	7200	5443	Gene	Gene	release|nmod|START_ENTITY release|amod|END_ENTITY	Catecholaminergic control of alpha-melanocyte-stimulating_hormone -LRB- alpha_MSH -RRB- release by frog neurointermediate lobe in vitro : evidence for direct stimulation of alpha_MSH release by thyrotropin-releasing_hormone .
6401174	0	thyrotropin-releasing_hormone	183,212	alpha_MSH	67,76	thyrotropin-releasing hormone	alpha MSH	7200	5443	Gene	Gene	release|nmod|START_ENTITY stimulation|nmod|release evidence|nmod|stimulation control|dep|evidence control|nmod|release release|appos|END_ENTITY	Catecholaminergic control of alpha-melanocyte-stimulating_hormone -LRB- alpha_MSH -RRB- release by frog neurointermediate lobe in vitro : evidence for direct stimulation of alpha_MSH release by thyrotropin-releasing_hormone .
10831641	0	thyrotropin-releasing_hormone	123,152	growth_hormone	29,43	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	modify|advcl|START_ENTITY modify|nsubj|therapy therapy|compound|END_ENTITY	Short-term recombinant human growth_hormone therapy does not modify growth_hormone , thyrotropin and prolactin responses to thyrotropin-releasing_hormone in adult dialysis patients .
10831641	0	thyrotropin-releasing_hormone	123,152	growth_hormone	68,82	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	modify|advcl|START_ENTITY modify|dobj|responses responses|compound|END_ENTITY	Short-term recombinant human growth_hormone therapy does not modify growth_hormone , thyrotropin and prolactin responses to thyrotropin-releasing_hormone in adult dialysis patients .
109274	2	thyrotropin-releasing_hormone	52,81	growth_hormone	122,136	thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of thyrotropin-releasing_hormone on in vitro biosynthesis and release of growth_hormone and prolactin .
11979395	0	thyrotropin-releasing_hormone	40,69	growth_hormone	13,27	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Preoperative growth_hormone response to thyrotropin-releasing_hormone and oral glucose tolerance test in acromegaly : a retrospective evaluation of 50 patients .
122426	0	thyrotropin-releasing_hormone	10,39	growth_hormone	65,79	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|compound|END_ENTITY	Effect of thyrotropin-releasing_hormone and bromoergocriptine on growth_hormone and prolactin secretion in perfused pituitary adenoma tissues of acromegaly .
1345574	0	thyrotropin-releasing_hormone	70,99	growth_hormone	14,28	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	responding|nmod|START_ENTITY levels|acl|responding levels|compound|END_ENTITY	Lower 24-hour growth_hormone levels in type I diabetics responding to thyrotropin-releasing_hormone -LRB- TRH -RRB- .
1355581	0	thyrotropin-releasing_hormone	85,114	growth_hormone	58,72	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	inhibition|acl|START_ENTITY inhibition|nmod|response response|compound|END_ENTITY	Corticotropin-releasing_hormone inhibition of paradoxical growth_hormone response to thyrotropin-releasing_hormone in insulin-dependent diabetics .
14551231	0	thyrotropin-releasing_hormone	91,120	growth_hormone	35,49	thyrotropin-releasing hormone	growth hormone	100346454(Tax:9986)	100356068(Tax:9986)	Gene	Gene	effects|amod|START_ENTITY effects|nmod|END_ENTITY	Endocrine and metabolic effects of growth_hormone -LRB- GH -RRB- compared with GH-releasing peptide , thyrotropin-releasing_hormone , and insulin infusion in a rabbit model of prolonged critical_illness .
15595273	0	thyrotropin-releasing_hormone	43,72	growth_hormone	14,28	thyrotropin-releasing hormone	growth hormone	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	Pit-1|amod|START_ENTITY Regulation|nmod|Pit-1 Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of growth_hormone expression by thyrotropin-releasing_hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary .
1624675	0	thyrotropin-releasing_hormone	182,211	growth_hormone	7,21	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	corticotropin-releasing_hormone|nmod|START_ENTITY END_ENTITY|advcl|corticotropin-releasing_hormone	Plasma growth_hormone -LRB- GH -RRB- responses to corticotropin-releasing_hormone in patients with acromegaly -- the effect of dexamethasone pretreatment and the comparison with GH responses to thyrotropin-releasing_hormone , gonadotropin-releasing_hormone and GH-releasing_hormone .
1696695	0	thyrotropin-releasing_hormone	143,172	growth_hormone	116,130	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	hormone|amod|START_ENTITY response|nmod|hormone response|amod|END_ENTITY	The natural course of growth_hormone-secreting pituitary_adenomas after surgery alone -- clinical significance of the growth_hormone response to thyrotropin-releasing_hormone and luteinizing hormone-releasing hormone .
1902488	0	thyrotropin-releasing_hormone	117,146	growth_hormone	24,38	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	peptide|amod|START_ENTITY effects|nmod|peptide comparison|nmod|effects response|dep|comparison response|nmod|histidine_methionine histidine_methionine|amod|peptide peptide|amod|END_ENTITY	Paradoxical response of growth_hormone to peptide histidine_methionine in acromegaly : comparison with the effects of thyrotropin-releasing_hormone and vasoactive intestinal peptide .
2128417	0	thyrotropin-releasing_hormone	100,129	growth_hormone	46,60	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	reduces|advcl|START_ENTITY reduces|dobj|levels levels|compound|END_ENTITY	Triiodothyronine administration reduces serum growth_hormone levels and growth_hormone responses to thyrotropin-releasing_hormone in patients with anorexia_nervosa .
2494101	0	thyrotropin-releasing_hormone	31,60	growth_hormone	106,120	thyrotropin-releasing hormone	growth hormone	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Triiodothyronine inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in anesthetized chickens .
2572506	0	thyrotropin-releasing_hormone	27,56	growth_hormone	102,116	thyrotropin-releasing hormone	growth hormone	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Somatostatin inhibition of thyrotropin-releasing_hormone - and growth_hormone-releasing factor-induced growth_hormone secretion in young and adult anesthetized chickens .
2862016	0	thyrotropin-releasing_hormone	105,134	growth_hormone	54,68	thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|suppression suppression|nmod|secretion secretion|amod|END_ENTITY	Hypothalamic somatostatin mediates the suppression of growth_hormone secretion by centrally administered thyrotropin-releasing_hormone in conscious rats .
3085739	0	thyrotropin-releasing_hormone	48,77	growth_hormone	21,35	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	response|acl|START_ENTITY response|compound|END_ENTITY	Is there paradoxical growth_hormone response to thyrotropin-releasing_hormone in depression ?
3097564	0	thyrotropin-releasing_hormone	22,51	growth_hormone	85,99	thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	evidence|amod|START_ENTITY participate|nsubj|evidence participate|nmod|regulation regulation|nmod|secretion secretion|amod|END_ENTITY	Further evidence that thyrotropin-releasing_hormone participate in the regulation of growth_hormone secretion in the rat .
3101755	0	thyrotropin-releasing_hormone	56,85	growth_hormone	28,42	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Thyrotropin , prolactin , and growth_hormone responses to thyrotropin-releasing_hormone in anorexia_nervosa and bulimia .
3102991	0	thyrotropin-releasing_hormone	10,39	growth_hormone	43,57	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Effect of thyrotropin-releasing_hormone on growth_hormone release in normal subjects pretreated with human pancreatic growth_hormone-releasing factor 1-44 pulsatile administration .
3106949	0	thyrotropin-releasing_hormone	33,62	growth_hormone	73,87	thyrotropin-releasing hormone	growth hormone	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of orally administered thyrotropin-releasing_hormone on plasma growth_hormone , thyroid hormones , growth , feed efficiency , and organ weights of broiler_chickens .
3107300	0	thyrotropin-releasing_hormone	61,90	growth_hormone	25,39	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|mediation mediation|nmod|secretion secretion|amod|END_ENTITY	Cholinergic mediation of growth_hormone secretion induced by thyrotropin-releasing_hormone in cirrhotic patients .
3108068	0	thyrotropin-releasing_hormone	93,122	growth_hormone	144,158	thyrotropin-releasing hormone	growth hormone	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|secretion secretion|amod|END_ENTITY	Effects of insulin-like_growth_factor_I -LRB- IGF-I -RRB- on growth_hormone-releasing factor -LRB- GRF -RRB- and thyrotropin-releasing_hormone -LRB- TRH -RRB- stimulation of growth_hormone -LRB- GH -RRB- secretion in the domestic fowl -LRB- Gallus_domesticus -RRB- .
3114818	0	thyrotropin-releasing_hormone	67,96	growth_hormone	40,54	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Effect|acl|START_ENTITY Effect|nmod|psychological_stress psychological_stress|nmod|response response|compound|END_ENTITY	Effect of psychological_stress on human growth_hormone response to thyrotropin-releasing_hormone in normal controls .
3917270	0	thyrotropin-releasing_hormone	126,155	growth_hormone	11,25	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	comparison|nmod|START_ENTITY Changes|dep|comparison Changes|nmod|secretion secretion|amod|END_ENTITY	Changes in growth_hormone -LRB- GH -RRB- secretion induced by human pancreatic GH releasing hormone-44 in acromegaly : a comparison with thyrotropin-releasing_hormone and bromocriptine .
3923021	0	thyrotropin-releasing_hormone	82,111	growth_hormone	146,160	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	START_ENTITY|nmod|patients patients|nmod|END_ENTITY	Different responses of growth_hormone secretion to guanfacine , bromocriptine , and thyrotropin-releasing_hormone in acromegalic patients with pure growth_hormone -LRB- GH -RRB- - containing and mixed GH/prolactin-containing pituitary_adenomas .
3932951	0	thyrotropin-releasing_hormone	71,100	growth_hormone	44,58	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	Thyroid-stimulating hormone , prolactin , and growth_hormone response to thyrotropin-releasing_hormone in treated children with congenital_hypothyroidism .
4007781	0	thyrotropin-releasing_hormone	41,70	growth_hormone	15,29	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of growth_hormone release by thyrotropin-releasing_hormone in elderly subjects .
403195	0	thyrotropin-releasing_hormone	51,80	growth_hormone	19,33	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	injection|amod|START_ENTITY levels|nmod|injection levels|compound|END_ENTITY	Increase in plasma growth_hormone levels following thyrotropin-releasing_hormone injection in children with primary_hypothyroidism .
405552	0	thyrotropin-releasing_hormone	69,98	growth_hormone	42,56	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Lack|acl|START_ENTITY Lack|nmod|effect effect|nmod|hormones hormones|nmod|response response|amod|END_ENTITY	Lack of effect of thyroid hormones on the growth_hormone response to thyrotropin-releasing_hormone in acromegaly .
406268	0	thyrotropin-releasing_hormone	11,40	growth_hormone	68,82	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|release release|compound|END_ENTITY	Effects of thyrotropin-releasing_hormone on sleep and sleep-related growth_hormone release in normal subjects .
6244936	0	thyrotropin-releasing_hormone	182,211	growth_hormone	147,161	thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	caused|nmod|START_ENTITY synthesis|acl|caused synthesis|amod|END_ENTITY	Action of cholera toxin on hormone synthesis and release in GH cells : evidence that adenosine_3 ' ,5 ' - monophosphate does not mediate the decrease in growth_hormone synthesis caused by thyrotropin-releasing_hormone .
6422486	0	thyrotropin-releasing_hormone	56,85	growth_hormone	21,35	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	infusion|amod|START_ENTITY secretion|nmod|infusion secretion|amod|END_ENTITY	Diurnal variation of growth_hormone secretion following thyrotropin-releasing_hormone infusion in normal men .
6434581	0	thyrotropin-releasing_hormone	31,60	growth_hormone	4,18	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	The growth_hormone response to thyrotropin-releasing_hormone in insulin-dependent diabetics involves a cholinergic mechanism .
6773980	0	thyrotropin-releasing_hormone	38,67	growth_hormone	10,24	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	responses|nmod|START_ENTITY responses|compound|END_ENTITY	Anomalous growth_hormone responses to thyrotropin-releasing_hormone and glucose in cirrhotic patients : the effect of metergoline .
6804479	0	thyrotropin-releasing_hormone	30,59	growth_hormone	12,26	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Response|acl|START_ENTITY Response|nmod|END_ENTITY	Response of growth_hormone to thyrotropin-releasing_hormone during fetal life .
7569294	0	thyrotropin-releasing_hormone	97,126	growth_hormone	26,40	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	stimulating|xcomp|START_ENTITY stimulating|nsubj|modulation modulation|nmod|END_ENTITY	Cholinergic modulation of growth_hormone , prolactin and thyroid stimulating hormone responses to thyrotropin-releasing_hormone in normal aging .
7853798	0	thyrotropin-releasing_hormone	74,103	growth_hormone	56,70	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Influence|acl|START_ENTITY Influence|nmod|erythropoietin erythropoietin|nmod|responses responses|nmod|END_ENTITY	Influence of erythropoietin on paradoxical responses of growth_hormone to thyrotropin-releasing_hormone in uremic patients .
7885285	0	thyrotropin-releasing_hormone	72,101	growth_hormone	45,59	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Effect|acl|START_ENTITY Effect|nmod|glucocorticoids glucocorticoids|nmod|response response|compound|END_ENTITY	Effect of glucocorticoids on the paradoxical growth_hormone response to thyrotropin-releasing_hormone in patients with acromegaly .
7991070	0	thyrotropin-releasing_hormone	205,234	growth_hormone	124,138	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	responses|nmod|START_ENTITY comparison|nmod|responses Lack|dep|comparison Lack|nmod|involvement involvement|nmod|mechanism mechanism|nmod|responses responses|compound|END_ENTITY	Lack of involvement of the cholinergic mechanism in vasoactive intestinal peptide - and peptide-histidine_methionine-induced growth_hormone -LRB- GH -RRB- responses in acromegaly : comparison with the GH responses to thyrotropin-releasing_hormone and GH-releasing_hormone .
8159113	0	thyrotropin-releasing_hormone	74,103	growth_hormone	47,61	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	Influence|acl|START_ENTITY Influence|nmod|status status|nmod|response response|compound|END_ENTITY	Influence of thyroid status on the paradoxical growth_hormone response to thyrotropin-releasing_hormone in human obesity .
816640	0	thyrotropin-releasing_hormone	41,70	growth_hormone	15,29	thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of growth_hormone release by thyrotropin-releasing_hormone in the hypophysectomized rat bearing an ectopic pituitary .
819245	0	thyrotropin-releasing_hormone	38,67	growth_hormone	71,85	thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Stimulating and inhibiting effects of thyrotropin-releasing_hormone on growth_hormone release in rats .
819251	0	thyrotropin-releasing_hormone	87,116	growth_hormone	53,67	thyrotropin-releasing hormone	growth hormone	25569(Tax:10116)	81668(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Effects Effects|nmod|hyperthyroidism hyperthyroidism|nmod|release release|compound|END_ENTITY	Effects of hyperthyroidism and hypothyroidism on rat growth_hormone release induced by thyrotropin-releasing_hormone .
820711	0	thyrotropin-releasing_hormone	15,44	growth_hormone	54,68	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	START_ENTITY|nmod|release release|amod|END_ENTITY	Suppression by thyrotropin-releasing_hormone -LRB- TRH -RRB- of growth_hormone release induced by arginine and insulin-induced hypoglycemia in man .
9675567	1	thyrotropin-releasing_hormone	80,109	growth_hormone	53,67	thyrotropin-releasing hormone	growth hormone	7200	2688	Gene	Gene	response|acl|START_ENTITY response|amod|END_ENTITY	II : Paradoxical growth_hormone response to thyrotropin-releasing_hormone .
98725	0	thyrotropin-releasing_hormone	14,43	growth_hormone	78,92	thyrotropin-releasing hormone	growth hormone	414344(Tax:9031)	378781(Tax:9031)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	The effect of thyrotropin-releasing_hormone -LRB- TRH -RRB- and somatostatin -LRB- GHRIH -RRB- on growth_hormone and prolactin secretion in vitro and in vivo in the domestic fowl -LRB- Gallus_domesticus -RRB- .
3131150	0	thyrotropin-releasing_hormone	98,127	growth_hormone-releasing_hormone	11,43	thyrotropin-releasing hormone	growth hormone-releasing hormone	25569(Tax:10116)	29446(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Effects of growth_hormone-releasing_hormone and corticotropin-releasing_hormone on the release of thyrotropin-releasing_hormone from the rat hypothalamus in vitro .
8127401	0	thyrotropin-releasing_hormone	15,44	interleukin-1-beta	64,82	thyrotropin-releasing hormone	interleukin-1-beta	25569(Tax:10116)	24494(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Suppression of thyrotropin-releasing_hormone gene expression by interleukin-1-beta in the rat : implications for nonthyroidal_illness .
11134186	0	thyrotropin-releasing_hormone	34,63	leptin	72,78	thyrotropin-releasing hormone	leptin	25569(Tax:10116)	25608(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of the thyrotropin-releasing_hormone gene by leptin and melanocortin signaling .
3140144	0	thyrotropin-releasing_hormone	16,45	neurotensin	57,68	thyrotropin-releasing hormone	neurotensin	25569(Tax:10116)	299757(Tax:10116)	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions of thyrotropin-releasing_hormone -LRB- TRH -RRB- with neurotensin and dopamine in the central nucleus of the amygdala during stress ulcer formation in rats .
3148872	0	thyrotropin-releasing_hormone	44,73	neurotensin	14,25	thyrotropin-releasing hormone	neurotensin	100346454(Tax:9986)	100354423(Tax:9986)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Antagonism Antagonism|nmod|END_ENTITY	Antagonism of neurotensin induced miosis by thyrotropin-releasing_hormone -LRB- TRH -RRB- in rabbits .
10598828	0	thyrotropin-releasing_hormone	23,52	orexin_A	11,19	thyrotropin-releasing hormone	orexin A	25569(Tax:10116)	25723(Tax:10116)	Gene	Gene	secretion|compound|START_ENTITY Effects|nmod|secretion Effects|nmod|END_ENTITY	Effects of orexin_A on thyrotropin-releasing_hormone and thyrotropin secretion in rats .
10406461	0	thyrotropin-releasing_hormone	76,105	prolactin	123,132	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	ability|nmod|START_ENTITY mediating|dobj|ability mediating|advcl|stimulate stimulate|dobj|promoter promoter|compound|END_ENTITY	A role for the mitogen-activated protein kinase in mediating the ability of thyrotropin-releasing_hormone to stimulate the prolactin promoter .
177274	0	thyrotropin-releasing_hormone	58,87	prolactin	91,100	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|nmod|release release|compound|END_ENTITY	A possible role of cyclic_AMP in mediating the effects of thyrotropin-releasing_hormone on prolactin release and on prolactin and growth_hormone synthesis in pituitary cells in culture .
1899114	0	thyrotropin-releasing_hormone	50,79	prolactin	19,28	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	potassium|amod|START_ENTITY induced|nmod|potassium secretion|acl|induced secretion|compound|END_ENTITY	Quinidine inhibits prolactin secretion induced by thyrotropin-releasing_hormone , high medium potassium or hyposmolarity in GH4C1 cells .
1908099	0	thyrotropin-releasing_hormone	113,142	prolactin	22,31	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	administration|amod|START_ENTITY diethylstilbestrol-treated|nmod|administration diethylstilbestrol-treated|nmod|END_ENTITY	Bioactivity of plasma prolactin in ovariectomized , diethylstilbestrol-treated Long-Evans and Holtzman rats after thyrotropin-releasing_hormone or bromocriptine administration .
1909855	0	thyrotropin-releasing_hormone	34,63	prolactin	12,21	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	Exaggerated|xcomp|START_ENTITY Exaggerated|dobj|response response|compound|END_ENTITY	Exaggerated prolactin response to thyrotropin-releasing_hormone in infertile women with the luteinized unruptured_follicle_syndrome .
19289102	0	thyrotropin-releasing_hormone	82,111	prolactin	126,135	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	MKP-1|nmod|START_ENTITY involvement|nmod|MKP-1 involvement|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Possible involvement of mitogen-activated_protein_kinase_phosphatase-1 -LRB- MKP-1 -RRB- in thyrotropin-releasing_hormone -LRB- TRH -RRB- - induced prolactin gene expression .
1947441	0	thyrotropin-releasing_hormone	37,66	prolactin	15,24	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- throughout the proliferative phases in the ovulatory and anovulatory menstrual cycle .
20960102	0	thyrotropin-releasing_hormone	114,143	prolactin	79,88	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY transcription|acl|induced transcription|compound|END_ENTITY	The transcription factor prolactin_regulatory_element-binding_protein mediates prolactin transcription induced by thyrotropin-releasing_hormone in GH3 cells .
2446857	0	thyrotropin-releasing_hormone	82,111	prolactin	50,59	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|role role|nmod|calcium calcium|nmod|regulation regulation|nmod|gene gene|compound|END_ENTITY	Preferential role of calcium in the regulation of prolactin gene transcription by thyrotropin-releasing_hormone in GH3 pituitary cells .
2492223	0	thyrotropin-releasing_hormone	37,66	prolactin	131,140	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	therapy|amod|START_ENTITY effectiveness|nmod|therapy influencing|dobj|effectiveness Factors|acl|influencing Factors|dep|significance significance|nmod|levels levels|compound|END_ENTITY	Factors influencing effectiveness of thyrotropin-releasing_hormone therapy for severe epilepsy in childhood : significance of serum prolactin levels .
2501668	0	thyrotropin-releasing_hormone	27,56	prolactin	104,113	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY transients|acl|induced lose|nsubj|transients lose|dobj|ability ability|acl|cause cause|dobj|release release|nmod|END_ENTITY	Ca2 + transients induced by thyrotropin-releasing_hormone rapidly lose their ability to cause release of prolactin .
3086358	0	thyrotropin-releasing_hormone	76,105	prolactin	48,57	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|response response|compound|END_ENTITY	Carbidopa plus L-dopa pretreatment inhibits the prolactin -LRB- PRL -RRB- response to thyrotropin-releasing_hormone and thus can not distinguish central from pituitary sites of prolactin stimulation .
3090397	0	thyrotropin-releasing_hormone	76,105	prolactin	127,136	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	antagonism|nmod|START_ENTITY effects|nmod|antagonism comparison|nmod|effects induced|nsubj|comparison induced|dobj|release release|compound|END_ENTITY	A comparison of the effects of suckling or transient dopamine antagonism on thyrotropin-releasing_hormone and suckling induced prolactin release in lactating rats .
3092268	0	thyrotropin-releasing_hormone	26,55	prolactin	4,13	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	START_ENTITY|nsubj|response response|compound|END_ENTITY	The prolactin response to thyrotropin-releasing_hormone in depressed patients and normal subjects .
3118231	0	thyrotropin-releasing_hormone	21,50	prolactin	62,71	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	actions|amod|START_ENTITY actions|nmod|release release|compound|END_ENTITY	Bradykinin parallels thyrotropin-releasing_hormone actions on prolactin release from rat anterior pituitary cells .
3119699	0	thyrotropin-releasing_hormone	38,67	prolactin	10,19	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|END_ENTITY	Subnormal prolactin responsiveness to thyrotropin-releasing_hormone -LRB- TRH -RRB- in women with primary_empty_sella_syndrome .
3137402	0	thyrotropin-releasing_hormone	101,130	prolactin	73,82	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|dep|START_ENTITY response|amod|END_ENTITY	Use of a pharmacokinetic model to characterize the thyrotropin -LRB- TSH -RRB- and prolactin -LRB- PRL -RRB- response to thyrotropin-releasing_hormone -LRB- THR -RRB- in man .
3926294	1	thyrotropin-releasing_hormone	100,129	prolactin	72,81	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	responsiveness|xcomp|START_ENTITY responsiveness|nsubj|Normalization Normalization|nmod|END_ENTITY	Normalization of exaggerated prolactin responsiveness to thyrotropin-releasing_hormone .
3930485	0	thyrotropin-releasing_hormone	39,68	prolactin	103,112	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	mechanisms|nmod|START_ENTITY mechanisms|nmod|transcription transcription|amod|END_ENTITY	Molecular mechanisms of phorbol_ester , thyrotropin-releasing_hormone , and growth_factor stimulation of prolactin gene transcription .
3932125	0	thyrotropin-releasing_hormone	85,114	prolactin	19,28	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	injection|nmod|START_ENTITY ridibunda|nmod|injection END_ENTITY|nmod|ridibunda	In vivo release of prolactin in Rana ridibunda following an intravenous injection of thyrotropin-releasing_hormone .
3932452	0	thyrotropin-releasing_hormone	26,55	prolactin	4,13	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	The prolactin response to thyrotropin-releasing_hormone does not distinguish teenaged males with hypogonadotropic_hypogonadism from those with constitutional_delay_of_growth_and_development .
3938733	0	thyrotropin-releasing_hormone	75,104	prolactin	24,33	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	infusion|nmod|START_ENTITY concentration|nmod|infusion concentration|nmod|END_ENTITY	Plasma concentration of prolactin during four-day osmotic pump infusion of thyrotropin-releasing_hormone and vasoactive_intestinal_polypeptide in rats .
403069	0	thyrotropin-releasing_hormone	78,107	prolactin	15,24	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Suppression Suppression|nmod|END_ENTITY	Suppression of prolactin and thyrotropin secretion in the rat by antiserum to thyrotropin-releasing_hormone .
404311	0	thyrotropin-releasing_hormone	37,66	prolactin	15,24	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Changes in the prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- during the menstrual cycle of normal women .
410851	0	thyrotropin-releasing_hormone	104,133	prolactin	25,34	thyrotropin-releasing hormone	prolactin	613414(Tax:9913)	280901(Tax:9913)	Gene	Gene	Response|nmod|START_ENTITY Response|nmod|END_ENTITY	Response of bovine serum prolactin and growth hormone to duodenal , abomasal , and oral administration of thyrotropin-releasing_hormone .
4199418	0	thyrotropin-releasing_hormone	56,85	prolactin	34,43	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|response response|compound|END_ENTITY	Thyroid hormone inhibition of the prolactin response to thyrotropin-releasing_hormone .
4213193	0	thyrotropin-releasing_hormone	15,44	prolactin	76,85	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|nmod|release release|nmod|END_ENTITY	Interaction of thyrotropin-releasing_hormone and dopamine on the release of prolactin from the rat anterior pituitary in vitro .
4626583	0	thyrotropin-releasing_hormone	147,176	prolactin	6,15	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	administration|nmod|START_ENTITY END_ENTITY|nmod|administration	Human prolactin and thyrotropin concentrations in the serums of normal and hypopituitary children before and after the administration of synthetic thyrotropin-releasing_hormone .
6436062	0	thyrotropin-releasing_hormone	55,84	prolactin	22,31	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	stimulation|amod|START_ENTITY sequential|dobj|stimulation Dissociation|acl|sequential Dissociation|nmod|response response|compound|END_ENTITY	Dissociation of serum prolactin response to sequential thyrotropin-releasing_hormone and chlorpromazine stimulation in patients with primary_empty_sella_syndrome .
6436160	2	thyrotropin-releasing_hormone	85,114	prolactin	63,72	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	Restoration|acl|START_ENTITY Restoration|nmod|response response|compound|END_ENTITY	Restoration of the prolactin response to thyrotropin-releasing_hormone by low-dose dopamine infusion in women with pathological hyperprolactinemia .
6773747	0	thyrotropin-releasing_hormone	14,43	prolactin	121,130	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	function|nsubj|START_ENTITY Evidence|dep|function Evidence|nmod|END_ENTITY	Evidence that thyrotropin-releasing_hormone and a hypothalamic prolactin-releasing factor may function in the release of prolactin in the lactating rat .
6774631	1	thyrotropin-releasing_hormone	214,243	prolactin	134,143	thyrotropin-releasing hormone	prolactin	25569(Tax:10116)	24683(Tax:10116)	Gene	Gene	Variation|nmod|START_ENTITY Variation|nmod|content content|compound|END_ENTITY	Variation in prolactin content of individual cell colonies , and dynamics of stimulation with thyrotropin-releasing_hormone -LRB- TRH -RRB- .
6778717	0	thyrotropin-releasing_hormone	34,63	prolactin	12,21	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Exaggerated prolactin response to thyrotropin-releasing_hormone and metoclopramide in primary testicular_failure .
6782838	0	thyrotropin-releasing_hormone	45,74	prolactin	6,15	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	Serum|xcomp|START_ENTITY Serum|dobj|responses responses|compound|END_ENTITY	Serum prolactin and thyrotropin responses to thyrotropin-releasing_hormone in men with alcoholic_cirrhosis .
6802681	0	thyrotropin-releasing_hormone	34,63	prolactin	12,21	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Exaggerated prolactin response of thyrotropin-releasing_hormone in women with anovulatory_cycles : possible role of endogenous estrogens and effect of bromocriptine .
6804899	0	thyrotropin-releasing_hormone	32,61	prolactin	10,19	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Increased prolactin response to thyrotropin-releasing_hormone in primary ovarian_failure .
808433	0	thyrotropin-releasing_hormone	29,58	prolactin	7,16	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	-LSB- Serum prolactin response to thyrotropin-releasing_hormone in normal subjects and in patients with thyroid_diseases -LRB- author 's transl -RRB- -RSB- .
809462	0	thyrotropin-releasing_hormone	99,128	prolactin	77,86	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	response|nmod|START_ENTITY response|compound|END_ENTITY	Effect of an oral water load on serum TSH in normal subjects , and on TSH and prolactin response to thyrotropin-releasing_hormone -LRB- TRH -RRB- in patients with primary_hypothyroidism .
8162388	0	thyrotropin-releasing_hormone	28,57	prolactin	6,15	thyrotropin-releasing hormone	prolactin	7200	5617	Gene	Gene	Serum|xcomp|START_ENTITY Serum|dobj|response response|compound|END_ENTITY	Serum prolactin response to thyrotropin-releasing_hormone during status_epilepticus .
9075462	0	thyrotropin-releasing_hormone	23,52	protirelin	54,64	thyrotropin-releasing hormone	protirelin	7200	7200	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of intrathecal thyrotropin-releasing_hormone -LRB- protirelin -RRB- in refractory depressed patients .
15305021	0	thyrotropin-releasing_hormone	71,100	pyroglutamyl_aminopeptidase_I	24,53	thyrotropin-releasing hormone	pyroglutamyl aminopeptidase I	25569(Tax:10116)	290648(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Marginal involvement of pyroglutamyl_aminopeptidase_I in metabolism of thyrotropin-releasing_hormone in rat brain .
9209609	0	thyrotropin-releasing_hormone	87,116	somatostatin	7,19	thyrotropin-releasing hormone	somatostatin	7200	6750	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	Plasma somatostatin correlates with blunted thyrotropin secretion after stimulation by thyrotropin-releasing_hormone in critical_illness .
10371211	0	thyrotropin-releasing_hormone_receptor	27,65	TRHR	67,71	thyrotropin-releasing hormone receptor	TRHR	25570(Tax:10116)	25570(Tax:10116)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Expression analysis of the thyrotropin-releasing_hormone_receptor -LRB- TRHR -RRB- in the immune system using agonist anti-TRHR monoclonal antibodies .
11064370	0	thyrotropin-releasing_hormone_receptor_2	14,54	TRH-R2	56,62	thyrotropin-releasing hormone receptor 2	TRH-R2	252859(Tax:10116)	252859(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of thyrotropin-releasing_hormone_receptor_2 -LRB- TRH-R2 -RRB- in the central nervous system of rats .
11716039	0	thyrotropin_receptor	25,45	Interleukin-6	0,13	thyrotropin receptor	Interleukin-6	7253	3569	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Interleukin-6 stimulates thyrotropin_receptor expression in human orbital preadipocyte fibroblasts from patients with Graves ' _ ophthalmopathy .
8135775	0	thyrotropin_receptor	13,33	TSH-R	35,40	thyrotropin receptor	TSH-R	22095(Tax:10090)	22095(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of thyrotropin_receptor -LRB- TSH-R -RRB- autoantibodies and thyroiditis in mice immunised with the recombinant TSH-R .
15911145	0	thyrotropin_receptor	27,47	TSHR	21,25	thyrotropin receptor	TSHR	7253	7253	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Polymorphisms in the TSHR -LRB- thyrotropin_receptor -RRB- gene on chromosome 14q31 are not associated with mental_retardation in the iodine-deficient areas of China .
16320156	0	thyrotropin_receptor	91,111	TSHR	113,117	thyrotropin receptor	TSHR	7253	7253	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Mild congenital primary_hypothyroidism in a Turkish family caused by a homozygous missense thyrotropin_receptor -LRB- TSHR -RRB- gene mutation -LRB- A593_V -RRB- .
23329763	0	thyrotropin_receptor	69,89	TSHR	91,95	thyrotropin receptor	TSHR	7253	7253	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mild and severe congenital primary_hypothyroidism in two patients by thyrotropin_receptor -LRB- TSHR -RRB- gene mutation .
8981017	0	thyrotropin_receptor	17,37	TSHR	39,43	thyrotropin receptor	TSHR	7253	7253	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The gene for the thyrotropin_receptor -LRB- TSHR -RRB- as a candidate gene for congenital_hypothyroidism with thyroid_dysgenesis .
12383251	0	thyrotropin_receptor	19,39	calnexin	45,53	thyrotropin receptor	calnexin	7253	821	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of the thyrotropin_receptor with calnexin , calreticulin and BiP .
7919995	0	thyrotropin_receptor	32,52	hTSHR	54,59	thyrotropin receptor	hTSHR	7253	7253	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphism of a variant human thyrotropin_receptor -LRB- hTSHR -RRB- gene .
11158064	0	thyrotropin_receptor	127,147	tumor_necrosis_factor-alpha	10,37	thyrotropin receptor	tumor necrosis factor-alpha	7253	7124	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha , interferon-gamma , and transforming_growth_factor-beta on adipogenesis and expression of thyrotropin_receptor in human orbital preadipocyte fibroblasts .
5003680	2	thyrotropin_releasing_factor	90,118	TRF	120,123	thyrotropin releasing factor	TRF	7200	7200	Gene	Gene	action|nmod|START_ENTITY action|appos|END_ENTITY	Biological action of synthetic thyrotropin_releasing_factor -LRB- TRF -RRB- in vivo and in vitro .
5841237	0	thyrotropin_releasing_factor	10,38	TRF	40,43	thyrotropin releasing factor	TRF	280825(Tax:9913)	280825(Tax:9913)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of thyrotropin_releasing_factor -LRB- TRF -RRB- of ovine , bovine , porcine and human origin on thyrotropin release in vitro and in vivo .
15256781	0	thyrotropin_releasing_hormone	19,48	Annexin_5	0,9	thyrotropin releasing hormone	Annexin 5	25569(Tax:10116)	25673(Tax:10116)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Annexin_5 inhibits thyrotropin_releasing_hormone -LRB- TRH -RRB- stimulated prolactin release in the primary culture of rat anterior pituitary cells .
1620073	0	thyrotropin_releasing_hormone	63,92	Growth_hormone	1,15	thyrotropin releasing hormone	Growth hormone	7200	2688	Gene	Gene	administration|nmod|START_ENTITY secretion|nmod|administration secretion|nsubj|END_ENTITY	-LSB- Growth_hormone secretion in response to the administration of thyrotropin_releasing_hormone -LRB- TRH -RRB- in children with insulin-dependent_diabetes_mellitus -RSB- .
111817	0	thyrotropin_releasing_hormone	17,46	TRH	48,51	thyrotropin releasing hormone	TRH	7200	7200	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	-LSB- Distribution of thyrotropin_releasing_hormone -LRB- TRH -RRB- , alpha-melanocyte-stimulating_hormone -LRB- alpha-MSH -RRB- and somatostatin in the skin of the green frog -LRB- Rana esculenta -RRB- -RSB- .
2889280	0	thyrotropin_releasing_hormone	11,40	TRH	42,45	thyrotropin releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of thyrotropin_releasing_hormone -LRB- TRH -RRB- on glutamate-induced seizures in rats .
3126991	0	thyrotropin_releasing_hormone	12,41	TRH	43,46	thyrotropin releasing hormone	TRH	7200	7200	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	-LSB- Release of thyrotropin_releasing_hormone -LRB- TRH -RRB- from human prolactin-secreting pituitary_adenoma cells .
822448	0	thyrotropin_releasing_hormone	13,42	TRH	44,47	thyrotropin releasing hormone	TRH	100346454(Tax:9986)	100346454(Tax:9986)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of thyrotropin_releasing_hormone -LRB- TRH -RRB- on drug-induced narcosis and hypothermia in rabbits .
8589718	0	thyrotropin_releasing_hormone	22,51	TRH	53,56	thyrotropin releasing hormone	TRH	25569(Tax:10116)	25569(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Ectopic expression of thyrotropin_releasing_hormone -LRB- TRH -RRB- receptors in liver modulates organ function to regulate blood glucose by TRH .
2500677	0	thyrotropin_releasing_hormone	81,110	growth_hormone	53,67	thyrotropin releasing hormone	growth hormone	7200	2688	Gene	Gene	responses|acl|START_ENTITY responses|amod|END_ENTITY	Abnormal_thyroid stimulating hormone , prolactin , and growth_hormone responses to thyrotropin_releasing_hormone in abstinent alcoholic men with cerebral_atrophy .
11916615	0	thyroxine-binding_globulin	26,52	TBG	54,57	thyroxine-binding globulin	TBG	6906	6906	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two novel variants in the thyroxine-binding_globulin -LRB- TBG -RRB- gene behind the diagnosis of TBG_deficiency .
6201364	0	thyroxine-binding_globulin	23,49	TBG	51,54	thyroxine-binding globulin	TBG	6906	6906	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Clinical evaluation of thyroxine-binding_globulin -LRB- TBG -RRB- as a marker of liver_tumors .
1384789	0	tie	27,30	receptor_tyrosine_kinase	31,55	tie	receptor tyrosine kinase	7075	5979	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Enhanced expression of the tie receptor_tyrosine_kinase in endothelial cells during neovascularization .
9301679	0	tie	14,17	receptor_tyrosine_kinase	18,42	tie	receptor tyrosine kinase	7075	5979	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of tie receptor_tyrosine_kinase in human leukemia cell lines .
15013125	0	tie-2	65,70	angiopoietin	43,55	tie-2	angiopoietin	7010	284	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Plasma angiopoietin-1 , angiopoietin-2 , and angiopoietin receptor tie-2 levels in congestive_heart_failure .
15548809	0	tie-2	93,98	vascular_endothelial_growth_factor	7,41	tie-2	vascular endothelial growth factor	7010	7422	Gene	Gene	receptor|dep|START_ENTITY receptor|compound|END_ENTITY	Plasma vascular_endothelial_growth_factor , angiopoietin-2 , and soluble angiopoietin receptor tie-2 in diabetic_retinopathy : effects of laser photocoagulation and angiotensin receptor blockade .
11334054	0	tie2	117,121	angiopoietin-1	88,102	tie2	angiopoietin-1	21687(Tax:10090)	11600(Tax:10090)	Gene	Gene	ligand|nmod|START_ENTITY END_ENTITY|appos|ligand	The 3T3-L1 fibroblast to adipocyte conversion is accompanied by increased expression of angiopoietin-1 , a ligand for tie2 .
11943723	0	tie2	18,22	angiopoietin-1	35,49	tie2	angiopoietin-1	7010	284	Gene	Gene	receptor|amod|START_ENTITY receptor|nmod|END_ENTITY	Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs_squamous_cell_carcinoma growth .
11705455	0	tight-skin	36,46	Tsk	48,51	tight-skin	Tsk	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Reduction in dermal fibrosis in the tight-skin -LRB- Tsk -RRB- mouse after local application of halofuginone .
1617705	0	tight-skin	95,105	Tsk	107,110	tight-skin	Tsk	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Granulated metrial gland cells in the pregnant uterus of mice expressing the collagen mutation tight-skin -LRB- Tsk / + -RRB- .
6604585	0	tight-skin	71,81	Tsk	83,86	tight-skin	Tsk	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Delayed-type_hypersensitivity to elastase-soluble lung peptides in the tight-skin -LRB- Tsk -RRB- mouse .
16924233	0	tight_junction_protein_occludin	34,65	Raf_1	0,5	tight junction protein occludin	Raf 1	100506658	5894	Gene	Gene	expression|nmod|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	Raf_1 represses expression of the tight_junction_protein_occludin via activation of the zinc-finger transcription factor slug .
16924233	0	tight_junction_protein_occludin	34,65	slug	121,125	tight junction protein occludin	slug	100506658	6591	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Raf_1 represses expression of the tight_junction_protein_occludin via activation of the zinc-finger transcription factor slug .
9405934	0	tight_skin	48,58	TSK	60,63	tight skin	TSK	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Structure of the mutant fibrillin-1 gene in the tight_skin -LRB- TSK -RRB- mouse .
17705049	0	tight_skin	38,48	Tsk	50,53	tight skin	Tsk	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mouse|amod|START_ENTITY mouse|appos|END_ENTITY	Marfan-like skeletal phenotype in the tight_skin -LRB- Tsk -RRB- mouse .
7902327	0	tight_skin	4,14	Tsk	16,19	tight skin	Tsk	14118(Tax:10090)	14118(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	The tight_skin -LRB- Tsk -RRB- mutation in the mouse , a model for human fibrotic_diseases , is tightly linked to the beta 2-microglobulin -LRB- B2m -RRB- gene on chromosome 2 .
16127425	0	tight_skin	16,26	Tsk1	28,32	tight skin	Tsk1	14118(Tax:10090)	22114(Tax:10090)	Gene	Gene	START_ENTITY|appos|+ +|compound|END_ENTITY	Analysis of the tight_skin -LRB- Tsk1 / + -RRB- mouse as a model for testing antifibrotic agents .
9504927	0	tim	35,38	clock	40,45	tim	clock	33571(Tax:7227)	38872(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Conserved regions of the timeless -LRB- tim -RRB- clock gene in Drosophila analyzed through phylogenetic and functional studies .
9504927	0	tim	35,38	timeless	25,33	tim	timeless	33571(Tax:7227)	33571(Tax:7227)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Conserved regions of the timeless -LRB- tim -RRB- clock gene in Drosophila analyzed through phylogenetic and functional studies .
22371007	0	tim-3	91,96	galectin-9	80,90	tim-3	galectin-9	84868	3965	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	The impaired immune regulation of autoimmune_hepatitis is linked to a defective galectin-9 / tim-3 pathway .
9891984	0	timeless	61,69	Timeless1	76,85	timeless	Timeless1	33571(Tax:7227)	33571(Tax:7227)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of the mammalian homologues of the Drosophila timeless gene , Timeless1 .
21359199	0	timeless	41,49	clock	27,32	timeless	clock	8914	9575	Gene	Gene	START_ENTITY|nsubj|role role|nmod|protein protein|compound|END_ENTITY	An unexpected role for the clock protein timeless in developmental apoptosis .
9504927	0	timeless	25,33	clock	40,45	timeless	clock	33571(Tax:7227)	38872(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Conserved regions of the timeless -LRB- tim -RRB- clock gene in Drosophila analyzed through phylogenetic and functional studies .
9504927	0	timeless	25,33	tim	35,38	timeless	tim	33571(Tax:7227)	33571(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Conserved regions of the timeless -LRB- tim -RRB- clock gene in Drosophila analyzed through phylogenetic and functional studies .
8557695	0	tip	76,79	p56lck	38,44	tip	p56lck	10524	3932	Gene	Gene	kinase|nmod|START_ENTITY kinase|dobj|END_ENTITY	Selective activation of T cell kinase p56lck by Herpesvirus_saimiri protein tip .
22385615	0	tip	88,91	serum_response_factor	30,51	tip	serum response factor	261726	6722	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Actin-dependent activation of serum_response_factor in T cells by the viral oncoprotein tip .
11004006	0	tissue-nonspecific_alkaline_phosphatase	11,50	PC-1	77,81	tissue-nonspecific alkaline phosphatase	PC-1	11647(Tax:10090)	18605(Tax:10090)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	Osteoblast tissue-nonspecific_alkaline_phosphatase antagonizes and regulates PC-1 .
10567438	0	tissue-nonspecific_alkaline_phosphatase	40,79	TNAP	81,85	tissue-nonspecific alkaline phosphatase	TNAP	25586(Tax:10116)	25586(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression and activity of tissue-nonspecific_alkaline_phosphatase -LRB- TNAP -RRB- in rat odontogenic cells in vivo .
10094560	0	tissue-nonspecific_alkaline_phosphatase	133,172	TNSALP	174,180	tissue-nonspecific alkaline phosphatase	TNSALP	249	249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of eleven novel mutations -LRB- M45L , R119H , 544delG , G145V , H154Y , C184Y , D289V , 862 +5 A , 1172delC , R411X , E459K -RRB- in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene in patients with severe hypophosphatasia .
10679946	0	tissue-nonspecific_alkaline_phosphatase	146,185	TNSALP	187,193	tissue-nonspecific alkaline phosphatase	TNSALP	249	249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Fifteen new mutations -LRB- -195 C > T , L-12X , 298-2A > G , T117N , A159T , R229S , 997 +2 T > A , E274X , A331T , H364R , D389G , 1256delC , R433H , N461I , C472S -RRB- in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene in patients with hypophosphatasia .
11745997	0	tissue-nonspecific_alkaline_phosphatase	175,214	TNSALP	216,222	tissue-nonspecific alkaline phosphatase	TNSALP	249	249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Perinatal hypophosphatasia : radiology , pathology and molecular biology studies in a family harboring a splicing mutation -LRB- 648 +1 A -RRB- and a novel missense mutation -LRB- N400S -RRB- in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene .
12357339	0	tissue-nonspecific_alkaline_phosphatase	37,76	TNSALP	78,84	tissue-nonspecific alkaline phosphatase	TNSALP	249	249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence of a founder effect for the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene E174K mutation in hypophosphatasia patients .
12416636	0	tissue-nonspecific_alkaline_phosphatase	48,87	TNSALP	89,95	tissue-nonspecific alkaline phosphatase	TNSALP	249	249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Severe hypophosphatasia due to mutations in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene .
9781036	0	tissue-nonspecific_alkaline_phosphatase	49,88	TNSALP	90,96	tissue-nonspecific alkaline phosphatase	TNSALP	249	249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of fifteen novel mutations in the tissue-nonspecific_alkaline_phosphatase -LRB- TNSALP -RRB- gene in European patients with severe hypophosphatasia .
8094535	0	tissue-plasminogen_activator	65,93	Thrombin	0,8	tissue-plasminogen activator	Thrombin	100128998	2147	Gene	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Thrombin generation and myocardial_infarction during infusion of tissue-plasminogen_activator .
8185344	0	tissue-polypeptide_antigen	22,48	TPA	50,53	tissue-polypeptide antigen	TPA	5327	5327	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	-LSB- Measurement of serum tissue-polypeptide_antigen -LRB- TPA -RRB- levels by EIA employing monoclonal antibody -RSB- .
9359841	0	tissue-type_plasminogen_activator	53,86	Calnexin	0,8	tissue-type plasminogen activator	Calnexin	5327	821	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	Calnexin and calreticulin bind to enzymically active tissue-type_plasminogen_activator during biosynthesis and are not required for folding to the native conformation .
8874752	0	tissue-type_plasminogen_activator	31,64	Interleukin-1_beta	0,18	tissue-type plasminogen activator	Interleukin-1 beta	5327	3553	Gene	Gene	upregulates|dobj|START_ENTITY upregulates|nsubj|END_ENTITY	Interleukin-1_beta upregulates tissue-type_plasminogen_activator in a keratinocyte cell line -LRB- HaCaT -RRB- .
3109496	0	tissue-type_plasminogen_activator	58,91	Interleukin_1	0,13	tissue-type plasminogen activator	Interleukin 1	5327	3552	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Interleukin_1 preferentially stimulates the production of tissue-type_plasminogen_activator by human articular chondrocytes .
10390010	0	tissue-type_plasminogen_activator	20,53	PAI-1	103,108	tissue-type plasminogen activator	PAI-1	5327	5054	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of tissue-type_plasminogen_activator -LRB- tPA -RRB- and its complex with the type-1 inhibitor -LRB- PAI-1 -RRB- in breast_cancer .
3124286	0	tissue-type_plasminogen_activator	62,95	Plasminogen_activator_inhibitor-1	0,33	tissue-type plasminogen activator	Plasminogen activator inhibitor-1	5327	5054	Gene	Gene	inhibitor|nmod|START_ENTITY inhibitor|nsubj|END_ENTITY	Plasminogen_activator_inhibitor-1 is the primary inhibitor of tissue-type_plasminogen_activator in pregnancy plasma .
9045716	0	tissue-type_plasminogen_activator	77,110	lipoprotein_receptor-related_protein	12,48	tissue-type plasminogen activator	lipoprotein receptor-related protein	5327	4035	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Low density lipoprotein_receptor-related_protein modulates the expression of tissue-type_plasminogen_activator in human colon fibroblasts .
16209928	0	tissue-type_plasminogen_activator	19,52	neuroserpin	64,75	tissue-type plasminogen activator	neuroserpin	5327	5274	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	The brain-specific tissue-type_plasminogen_activator inhibitor , neuroserpin , protects neurons against excitotoxicity both in vitro and in vivo .
11385207	0	tissue-type_plasminogen_activator	108,141	plasminogen_activator_inhibitor-1	26,59	tissue-type plasminogen activator	plasminogen activator inhibitor-1	5327	5054	Gene	Gene	gene|amod|START_ENTITY gene|nmod|gene gene|amod|END_ENTITY	4G/5G polymorphism of the plasminogen_activator_inhibitor-1 gene and insertion/deletion polymorphism of the tissue-type_plasminogen_activator gene in atherothrombotic_stroke .
1601844	0	tissue-type_plasminogen_activator	129,162	plasminogen_activator_inhibitor-1	54,87	tissue-type plasminogen activator	plasminogen activator inhibitor-1	5327	5054	Gene	Gene	substrate|nmod|START_ENTITY acting|nmod|substrate acting|nsubj|Identification Identification|nmod|form form|nmod|END_ENTITY	Identification of a conformationally distinct form of plasminogen_activator_inhibitor-1 , acting as a noninhibitory substrate for tissue-type_plasminogen_activator .
1648385	0	tissue-type_plasminogen_activator	81,114	plasminogen_activator_inhibitor-1	116,149	tissue-type plasminogen activator	plasminogen activator inhibitor-1	5327	5054	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Role of protein kinase C and cyclic_adenosine_monophosphate in the regulation of tissue-type_plasminogen_activator , plasminogen_activator_inhibitor-1 , and platelet-derived growth factor mRNA levels in human endothelial cells .
7662701	0	tissue-type_plasminogen_activator	72,105	plasminogen_activator_inhibitor-1	106,139	tissue-type plasminogen activator	plasminogen activator inhibitor-1	5327	5054	Gene	Gene	complexes|amod|START_ENTITY complexes|amod|END_ENTITY	Cathepsin_D-like aspartyl protease activity mediates the degradation of tissue-type_plasminogen_activator / plasminogen_activator_inhibitor-1 complexes in human monocytes .
9256087	0	tissue-type_plasminogen_activator	174,207	plasminogen_activator_inhibitor-1	124,157	tissue-type plasminogen activator	plasminogen activator inhibitor-1	5327	5054	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells : astragaloside_IV downregulates plasminogen_activator_inhibitor-1 and upregulates tissue-type_plasminogen_activator expression .
11450845	0	tissue-type_plasminogen_activator	109,142	t-PA	144,148	tissue-type plasminogen activator	t-PA	5327	5327	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage disequilibrium and haplotype analysis among eight novel single-nucleotide polymorphisms in the human tissue-type_plasminogen_activator -LRB- t-PA -RRB- gene .
19931890	0	tissue-type_plasminogen_activator	11,44	t-PA	46,50	tissue-type plasminogen activator	t-PA	397121(Tax:9823)	397121(Tax:9823)	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of tissue-type_plasminogen_activator -LRB- t-PA -RRB- in the splanchnic circulation of the anaesthetised pig during high sympathetic tone .
3937265	0	tissue-type_plasminogen_activator	15,48	t-PA	50,54	tissue-type plasminogen activator	t-PA	5327	5327	Gene	Gene	Assay|nmod|START_ENTITY Assay|appos|END_ENTITY	Assay of human tissue-type_plasminogen_activator -LRB- t-PA -RRB- with an enzyme-linked immunosorbent assay -LRB- ELISA -RRB- based on three murine monoclonal antibodies to t-PA .
9099997	0	tissue-type_plasminogen_activator	15,48	t-PA	50,54	tissue-type plasminogen activator	t-PA	5327	5327	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Enhancement of tissue-type_plasminogen_activator -LRB- t-PA -RRB- activity by purified t-PA receptor expressed in human endothelial cells .
12408467	0	tissue-type_plasminogen_activator	27,60	tPA	62,65	tissue-type plasminogen activator	tPA	5327	5327	Gene	Gene	content|amod|START_ENTITY content|appos|END_ENTITY	Prognostic significance of tissue-type_plasminogen_activator -LRB- tPA -RRB- content in gastric_cancer and surrounding mucosa .
21519332	0	tissue-type_plasminogen_activator	45,78	tPA	80,83	tissue-type plasminogen activator	tPA	18791(Tax:10090)	18791(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Compartment - and context-specific changes in tissue-type_plasminogen_activator -LRB- tPA -RRB- activity following brain_injury and pharmacological stimulation .
3137452	0	tissue-type_plasminogen_activator	28,61	tPA	63,66	tissue-type plasminogen activator	tPA	25692(Tax:10116)	25692(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Dexamethasone inhibition of tissue-type_plasminogen_activator -LRB- tPA -RRB- activity : paradoxical induction of both tPA antigen and plasminogen activator inhibitor .
8953506	0	tissue-type_plasminogen_activator	30,63	tissue-type_plasminogen_activator	79,112	tissue-type plasminogen activator	tissue-type plasminogen activator	482840(Tax:9615)	482840(Tax:9615)	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative study of a mutant tissue-type_plasminogen_activator , YM866 , with a tissue-type_plasminogen_activator in a canine model of femoral arterial_thrombosis .
8953506	0	tissue-type_plasminogen_activator	79,112	tissue-type_plasminogen_activator	30,63	tissue-type plasminogen activator	tissue-type plasminogen activator	482840(Tax:9615)	482840(Tax:9615)	Gene	Gene	study|nmod|START_ENTITY study|nmod|END_ENTITY	Comparative study of a mutant tissue-type_plasminogen_activator , YM866 , with a tissue-type_plasminogen_activator in a canine model of femoral arterial_thrombosis .
3114253	0	tissue-type_plasminogen_activator	73,106	urokinase-type_plasminogen_activator	137,173	tissue-type plasminogen activator	urokinase-type plasminogen activator	5327	5328	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a recombinant fusion protein of the finger domain of tissue-type_plasminogen_activator with a truncated single chain urokinase-type_plasminogen_activator .
3146822	0	tissue-type_plasminogen_activator	111,144	urokinase-type_plasminogen_activator	213,249	tissue-type plasminogen activator	urokinase-type plasminogen activator	5327	5328	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a chimaeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type_plasminogen_activator -LRB- amino_acids 173 through 262 -RRB- between residues Asp130 and Ser139 of urokinase-type_plasminogen_activator .
18550154	0	tissue_factor	110,123	Protein_disulfide_isomerase	0,27	tissue factor	Protein disulfide isomerase	101909187	281373(Tax:9913)	Gene	Gene	has|nmod|START_ENTITY has|nsubj|END_ENTITY	Protein_disulfide_isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue_factor .
11601238	0	tissue_factor	27,40	thrombin	15,23	tissue factor	thrombin	101909187	280685(Tax:9913)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	-LSB- The effect of thrombin on tissue_factor activity in cultured bovine aortic endothelial cells and its correlation with PKC pathway -RSB- .
12212197	0	tissue_factor	80,93	tumor_necrosis_factor_alpha	105,132	tissue factor	tumor necrosis factor alpha	101909187	280943(Tax:9913)	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	-LSB- Effects of Buyang huanwu decoction on the release of vWF and the expression of tissue_factor induced by tumor_necrosis_factor_alpha in cultured bovine aortic endothelial cells -RSB- .
16520718	0	tissue_factor_pathway_inhibitor	58,89	C-reactive_protein	21,39	tissue factor pathway inhibitor	C-reactive protein	7035	1401	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Inhibitory effect of C-reactive_protein on the release of tissue_factor_pathway_inhibitor from human endothelial cells : reversal by low molecular weight heparin .
9423800	0	tissue_factor_pathway_inhibitor	6,37	FXa	62,65	tissue factor pathway inhibitor	FXa	7035	2159	Gene	Gene	binds|nsubj|START_ENTITY binds|dobj|END_ENTITY	Human tissue_factor_pathway_inhibitor fused to CD4 binds both FXa and TF/FVIIa at the cell surface .
9716152	0	tissue_factor_pathway_inhibitor	22,53	Factor_Xa	0,9	tissue factor pathway inhibitor	Factor Xa	7035	2159	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	Factor_Xa cleavage of tissue_factor_pathway_inhibitor is associated with loss of anticoagulant activity .
17479196	0	tissue_factor_pathway_inhibitor	73,104	GATA-2	17,23	tissue factor pathway inhibitor	GATA-2	7035	2624	Gene	Gene	roles|nmod|START_ENTITY roles|nmod|END_ENTITY	Crucial roles of GATA-2 and SP1 in adrenomedullin-affected expression of tissue_factor_pathway_inhibitor in human umbilical vein endothelial cells exposed to lipopolysaccharide .
18217145	0	tissue_factor_pathway_inhibitor	19,50	Heparanase	0,10	tissue factor pathway inhibitor	Heparanase	7035	10855	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Heparanase induces tissue_factor_pathway_inhibitor expression and extracellular accumulation in endothelial and tumor cells .
10195910	0	tissue_factor_pathway_inhibitor	21,52	TFPI	54,58	tissue factor pathway inhibitor	TFPI	7035	7035	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of the tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- gene in patients with acute_coronary_syndromes and in healthy subjects : impact of the V264M substitution on plasma levels of TFPI .
11372675	0	tissue_factor_pathway_inhibitor	32,63	TFPI	65,69	tissue factor pathway inhibitor	TFPI	7035	7035	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Plasma levels of total and free tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- as individual pharmacological parameters of various heparins .
12560220	0	tissue_factor_pathway_inhibitor	14,45	TFPI	47,51	tissue factor pathway inhibitor	TFPI	7035	7035	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Low levels of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- increase the risk of venous_thrombosis .
1332210	0	tissue_factor_pathway_inhibitor	10,41	TFPI	43,47	tissue factor pathway inhibitor	TFPI	7035	7035	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- in the HEPTEST assay and in an amidolytic anti factor Xa assay for LMW heparin .
1412217	0	tissue_factor_pathway_inhibitor	16,47	TFPI	119,123	tissue factor pathway inhibitor	TFPI	7035	100009401(Tax:9986)	Gene	Gene	Purification|nmod|START_ENTITY Purification|nmod|END_ENTITY	Purification of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- from rabbit plasma and characterization of its differences from TFPI isolated from human plasma .
16581344	0	tissue_factor_pathway_inhibitor	25,56	TFPI	103,107	tissue factor pathway inhibitor	TFPI	7035	7035	Gene	Gene	Impact|nmod|START_ENTITY Impact|nmod|END_ENTITY	Impact of native VLDL on tissue_factor_pathway_inhibitor in endothelial cells and interactions between TFPI and lipoprotein_lipase .
8588202	0	tissue_factor_pathway_inhibitor	14,45	TFPI	47,51	tissue factor pathway inhibitor	TFPI	7035	7035	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Low levels of tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- in two out of three members of a family with thrombophilia .
9974373	0	tissue_factor_pathway_inhibitor	42,73	TFPI	75,79	tissue factor pathway inhibitor	TFPI	21788(Tax:10090)	21788(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	TFPIbeta , a second product from the mouse tissue_factor_pathway_inhibitor -LRB- TFPI -RRB- gene .
7583589	0	tissue_factor_pathway_inhibitor	57,88	Thrombin	0,8	tissue factor pathway inhibitor	Thrombin	7035	2147	Gene	Gene	release|nmod|START_ENTITY induces|dobj|release induces|nsubj|END_ENTITY	Thrombin induces the redistribution and acute release of tissue_factor_pathway_inhibitor from specific granules within human endothelial cells in culture .
11816723	0	tissue_factor_pathway_inhibitor	14,45	interleukin-1	88,101	tissue factor pathway inhibitor	interleukin-1	7035	3552	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of tissue_factor_pathway_inhibitor in cardiomyocytes and its upregulation by interleukin-1 .
23374966	0	tissue_factor_pathway_inhibitor	14,45	monocyte_chemotactic_protein-3	67,97	tissue factor pathway inhibitor	monocyte chemotactic protein-3	7035	6354	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	The effect of tissue_factor_pathway_inhibitor on the expression of monocyte_chemotactic_protein-3 and IkB-a stimulated by tumour_necrosis_factor-a in cultured vascular smooth muscle cells .
19233920	0	tissue_factor_pathway_inhibitor	55,86	thrombin-activatable_fibrinolysis_inhibitor	102,145	tissue factor pathway inhibitor	thrombin-activatable fibrinolysis inhibitor	7035	1361	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Increased plasminogen_activator_inhibitor-1 , decreased tissue_factor_pathway_inhibitor , and unchanged thrombin-activatable_fibrinolysis_inhibitor levels in patients with primary_hyperparathyroidism .
10494762	0	tissue_factor_pathway_inhibitor	30,61	thrombomodulin_and_von_Willebrand_factor	63,103	tissue factor pathway inhibitor	thrombomodulin and von Willebrand factor	7035	7056;7450	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Transcriptional expression of tissue_factor_pathway_inhibitor , thrombomodulin_and_von_Willebrand_factor in normal human tissues .
25036127	0	tissue_factor_pathway_inhibitor-2	14,47	LSD1	108,112	tissue factor pathway inhibitor-2	LSD1	7980	23028	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
11448060	0	tissue_factor_pathway_inhibitor-2	8,41	TFPI-2	43,49	tissue factor pathway inhibitor-2	TFPI-2	7980	7980	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- in amelanotic_melanoma -LRB- C-32 -RRB- invasion .
11687973	0	tissue_factor_pathway_inhibitor-2	20,53	TFPI-2	55,61	tissue factor pathway inhibitor-2	TFPI-2	7980	7980	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	A novel function of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- in human glioma_invasion .
25036127	0	tissue_factor_pathway_inhibitor-2	14,47	TFPI-2	49,55	tissue factor pathway inhibitor-2	TFPI-2	7980	7980	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
25036127	0	tissue_factor_pathway_inhibitor-2	14,47	lysine-specific_demethylase_1	71,100	tissue factor pathway inhibitor-2	lysine-specific demethylase 1	7980	23028	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of tissue_factor_pathway_inhibitor-2 -LRB- TFPI-2 -RRB- expression by lysine-specific_demethylase_1 and 2 -LRB- LSD1 and LSD2 -RRB- .
15735751	0	tissue_factor_pathway_inhibitor_2	71,104	TFPI-2	106,112	tissue factor pathway inhibitor 2	TFPI-2	7980	7980	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Sequential 5-Aza_2 ' - deoxycytidine/depsipeptide FK228 treatment induces tissue_factor_pathway_inhibitor_2 -LRB- TFPI-2 -RRB- expression in cancer cells .
17154296	0	tissue_inhibitor-2_of_matrix_metalloproteinases	98,145	MMP-2	80,85	tissue inhibitor-2 of matrix metalloproteinases	MMP-2	282093(Tax:9913)	282872(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Quantitative analysis of messenger RNA expression of matrix metalloproteinases -LRB- MMP-2 and MMP-9 -RRB- , tissue_inhibitor-2_of_matrix_metalloproteinases -LRB- TIMP-2 -RRB- , and steroidogenic enzymes in bovine placentomes during gestation and postpartum .
24283658	0	tissue_inhibitor_of_MMP-1	37,62	TIMP-1	64,70	tissue inhibitor of MMP-1	TIMP-1	7076	7076	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Matrix_metalloproteinase _ -LRB- MMP -RRB- -8 and tissue_inhibitor_of_MMP-1 -LRB- TIMP-1 -RRB- gene polymorphisms in generalized aggressive periodontitis : gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy .
14674693	0	tissue_inhibitor_of_matrix_metalloproteinase-1	61,107	TIMP-1	109,115	tissue inhibitor of matrix metalloproteinase-1	TIMP-1	282092(Tax:9913)	282092(Tax:9913)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Identification , purification and partial characterization of tissue_inhibitor_of_matrix_metalloproteinase-1 -LRB- TIMP-1 -RRB- in bovine pulmonary artery smooth muscle .
21731773	0	tissue_inhibitor_of_metalloproteases-1	37,75	TIMP-1	77,83	tissue inhibitor of metalloproteases-1	TIMP-1	7076	7076	Gene	Gene	degradation|amod|START_ENTITY degradation|appos|END_ENTITY	Mechanism of heparin acceleration of tissue_inhibitor_of_metalloproteases-1 -LRB- TIMP-1 -RRB- degradation by the human neutrophil elastase .
21631912	0	tissue_inhibitor_of_metalloproteinase	39,76	TIMP	78,82	tissue inhibitor of metalloproteinase	TIMP	7076	7076	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A dual role for microglia in promoting tissue_inhibitor_of_metalloproteinase -LRB- TIMP -RRB- expression in glial cells in response to neuroinflammatory stimuli .
22823240	0	tissue_inhibitor_of_metalloproteinase	45,82	TIMP-1	84,90	tissue inhibitor of metalloproteinase	TIMP-1	7076	7076	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Stromelysin -LRB- matrix metalloproteinase-3 -RRB- and tissue_inhibitor_of_metalloproteinase -LRB- TIMP-1 -RRB- mRNA expression in scleritis .
8808115	0	tissue_inhibitor_of_metalloproteinase	25,62	TIMP-1	64,70	tissue inhibitor of metalloproteinase	TIMP-1	116510(Tax:10116)	116510(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Glomerular expression of tissue_inhibitor_of_metalloproteinase -LRB- TIMP-1 -RRB- in normal and diabetic rats .
10222217	0	tissue_inhibitor_of_metalloproteinase-1	98,137	TIMP-1	139,145	tissue inhibitor of metalloproteinase-1	TIMP-1	100009047(Tax:9986)	100009047(Tax:9986)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The effects of hyaluronan on matrix_metalloproteinase-3 -LRB- MMP-3 -RRB- , interleukin-1beta -LRB- IL-1beta -RRB- , and tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- gene expression during the development of osteoarthritis .
11988491	0	tissue_inhibitor_of_metalloproteinase-1	96,135	TIMP-1	137,143	tissue inhibitor of metalloproteinase-1	TIMP-1	21857(Tax:10090)	21857(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- gene .
1330702	0	tissue_inhibitor_of_metalloproteinase-1	13,52	TIMP-1	54,60	tissue inhibitor of metalloproteinase-1	TIMP-1	7076	7076	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in human hepatoma cells -LRB- HepG2 -RRB- .
19485944	0	tissue_inhibitor_of_metalloproteinase-1	34,73	TIMP-1	75,81	tissue inhibitor of metalloproteinase-1	TIMP-1	7076	7076	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in invasive breast_carcinoma .
8879438	0	tissue_inhibitor_of_metalloproteinase-1	13,52	TIMP-1	54,60	tissue inhibitor of metalloproteinase-1	TIMP-1	100009047(Tax:9986)	100009047(Tax:9986)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of tissue_inhibitor_of_metalloproteinase-1 -LRB- TIMP-1 -RRB- in rabbit aortic neointima after selective de-endothelialization .
11160345	0	tissue_inhibitor_of_metalloproteinase-1	10,49	alpha-chymase	96,109	tissue inhibitor of metalloproteinase-1	alpha-chymase	21857(Tax:10090)	17228(Tax:10090)	Gene	Gene	cleaved|nsubjpass|START_ENTITY cleaved|nmod|END_ENTITY	Mast cell tissue_inhibitor_of_metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase .
10808169	0	tissue_inhibitor_of_metalloproteinase-1	35,74	matrix_metalloproteinase-9	7,33	tissue inhibitor of metalloproteinase-1	matrix metalloproteinase-9	7076	4318	Gene	Gene	ratio|amod|START_ENTITY ratio|dep|END_ENTITY	Sputum matrix_metalloproteinase-9 : tissue_inhibitor_of_metalloproteinase-1 ratio in acute asthma .
9057817	0	tissue_inhibitor_of_metalloproteinase-1	33,72	oncostatin_M	107,119	tissue inhibitor of metalloproteinase-1	oncostatin M	100770193	100758591	Gene	Gene	cells|amod|START_ENTITY induction|nmod|cells induction|nmod|END_ENTITY	Autocrine/paracrine induction of tissue_inhibitor_of_metalloproteinase-1 in Chinese_hamster ovary cells by oncostatin_M .
11823524	0	tissue_inhibitor_of_metalloproteinase-2	36,75	IL-4	0,4	tissue inhibitor of metalloproteinase-2	IL-4	7077	3565	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	IL-4 up-regulates the expression of tissue_inhibitor_of_metalloproteinase-2 in dermal fibroblasts via the p38_mitogen-activated_protein_kinase dependent pathway .
17325663	0	tissue_inhibitor_of_metalloproteinase-2	31,70	TIMP-2	72,78	tissue inhibitor of metalloproteinase-2	TIMP-2	7077	7077	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Epigenetic inactivation of the tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- gene in human prostate_tumors .
19751965	0	tissue_inhibitor_of_metalloproteinase-2	12,51	TIMP-2	53,59	tissue inhibitor of metalloproteinase-2	TIMP-2	7077	7077	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Increase in tissue_inhibitor_of_metalloproteinase-2 -LRB- TIMP-2 -RRB- levels and inhibition of MMP-2 activity in a metastatic breast_cancer cell line by an anti-invasive small molecule SR13179 .
15714128	0	tissue_inhibitor_of_metalloproteinase-3	19,58	TIMP3	60,65	tissue inhibitor of metalloproteinase-3	TIMP3	7078	7078	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alterations of the tissue_inhibitor_of_metalloproteinase-3 -LRB- TIMP3 -RRB- gene in pancreatic_adenocarcinomas .
10931526	0	tissue_inhibitor_of_metalloproteinase-3	14,53	Timp-3	55,61	tissue inhibitor of metalloproteinase-3	Timp-3	25358(Tax:10116)	25358(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Regulation of tissue_inhibitor_of_metalloproteinase-3 -LRB- Timp-3 -RRB- mRNA expression during rat CNS development .
9693046	0	tissue_inhibitor_of_metalloproteinase-4	21,60	TIMP4	67,72	tissue inhibitor of metalloproteinase-4	TIMP4	7079	7079	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning of the human tissue_inhibitor_of_metalloproteinase-4 gene -LRB- TIMP4 -RRB- and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6 , respectively .
15051730	0	tissue_inhibitor_of_metalloproteinase_1	14,53	RUNX1	76,81	tissue inhibitor of metalloproteinase 1	RUNX1	7076	861	Gene	Gene	gene|amod|START_ENTITY Regulation|nmod|gene transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of tissue_inhibitor_of_metalloproteinase_1 gene transcription by RUNX1 and RUNX2 .
12515831	0	tissue_inhibitor_of_metalloproteinase_1	27,66	TIMP-1	68,74	tissue inhibitor of metalloproteinase 1	TIMP-1	7076	7076	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Protein engineering of the tissue_inhibitor_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- inhibitory domain .
23017058	0	tissue_inhibitor_of_metalloproteinase_1	106,145	cathepsin_B	79,90	tissue inhibitor of metalloproteinase 1	cathepsin B	21857(Tax:10090)	13030(Tax:10090)	Gene	Gene	degradation|nmod|START_ENTITY degradation|amod|END_ENTITY	Activation of the P2X receptor induces migration of glial cells by inducing cathepsin_B degradation of tissue_inhibitor_of_metalloproteinase_1 .
25153068	0	tissue_inhibitor_of_metalloproteinase_2	97,136	TIMP2	138,143	tissue inhibitor of metalloproteinase 2	TIMP2	7077	7077	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	A chromatin modifier regulates Sertoli cell response to mono - -LRB- 2-ethylhexyl -RRB- _ phthalate -LRB- MEHP -RRB- via tissue_inhibitor_of_metalloproteinase_2 -LRB- TIMP2 -RRB- signaling .
2166509	0	tissue_inhibitor_of_metalloproteinases	41,79	Interleukin_6	0,13	tissue inhibitor of metalloproteinases	Interleukin 6	7076	3569	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interleukin_6 enhances the production of tissue_inhibitor_of_metalloproteinases -LRB- TIMP -RRB- but not that of matrix metalloproteinases by human fibroblasts .
3894382	0	tissue_inhibitor_of_metalloproteinases	22,60	TIMP	62,66	tissue inhibitor of metalloproteinases	TIMP	7076	7076	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of tissue_inhibitor_of_metalloproteinases -LRB- TIMP -RRB- in human cells .
1654118	0	tissue_inhibitor_of_metalloproteinases	65,103	Transforming_growth_factor_beta	0,31	tissue inhibitor of metalloproteinases	Transforming growth factor beta	7076	7040	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Transforming_growth_factor_beta stimulates the production of the tissue_inhibitor_of_metalloproteinases -LRB- TIMP -RRB- by human synovial and skin fibroblasts .
3903517	0	tissue_inhibitor_of_metalloproteinases	18,56	erythroid-potentiating_activity	77,108	tissue inhibitor of metalloproteinases	erythroid-potentiating activity	7076	7076	Gene	Gene	Sequence|nmod|START_ENTITY Sequence|nmod|END_ENTITY	Sequence of human tissue_inhibitor_of_metalloproteinases and its identity to erythroid-potentiating_activity .
10866818	0	tissue_inhibitor_of_metalloproteinases-1	33,73	TIMP-1	75,81	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Mechanisms of induction of human tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- gene expression by all-trans_retinoic_acid in combination with basic_fibroblast_growth_factor .
14669077	0	tissue_inhibitor_of_metalloproteinases-1	16,56	TIMP-1	58,64	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in colorectal_cancer patients .
17160480	0	tissue_inhibitor_of_metalloproteinases-1	31,71	TIMP-1	73,79	tissue inhibitor of metalloproteinases-1	TIMP-1	116510(Tax:10116)	116510(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibitory effect of emodin on tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- expression in rat hepatic stellate cells .
24998777	0	tissue_inhibitor_of_metalloproteinases-1	77,117	TIMP-1	119,125	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Purification and characterization of bioactive his6-tagged recombinant human tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- protein expressed at high yields in mammalian cells .
7614380	0	tissue_inhibitor_of_metalloproteinases-1	18,58	TIMP-1	60,66	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of a tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in bladder_cancer patients .
8518299	0	tissue_inhibitor_of_metalloproteinases-1	23,63	TIMP-1	65,71	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Structural analysis of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- by tryptic peptide mapping .
8532127	0	tissue_inhibitor_of_metalloproteinases-1	14,54	TIMP-1	56,62	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- by human astrocytic_tumors .
8559663	0	tissue_inhibitor_of_metalloproteinases-1	77,117	TIMP-1	119,125	tissue inhibitor of metalloproteinases-1	TIMP-1	116510(Tax:10116)	116510(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Identification of the interleukin-6 / oncostatin_M response element in the rat tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- promoter .
8608981	0	tissue_inhibitor_of_metalloproteinases-1	27,67	TIMP-1	69,75	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced RNA expression of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in human breast_cancer .
9547291	0	tissue_inhibitor_of_metalloproteinases-1	38,78	TIMP-1	80,86	tissue inhibitor of metalloproteinases-1	TIMP-1	7076	7076	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|appos|END_ENTITY	Cell cycle-associated accumulation of tissue_inhibitor_of_metalloproteinases-1 -LRB- TIMP-1 -RRB- in the nuclei of human gingival fibroblasts .
10428785	0	tissue_inhibitor_of_metalloproteinases-1	99,139	Timp-1	141,147	tissue inhibitor of metalloproteinases-1	Timp-1	21857(Tax:10090)	21857(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A sequence-selective single-strand DNA-binding protein regulates basal transcription of the murine tissue_inhibitor_of_metalloproteinases-1 -LRB- Timp-1 -RRB- gene .
8129795	0	tissue_inhibitor_of_metalloproteinases-1	44,84	Transforming_growth_factor_beta_1	0,33	tissue inhibitor of metalloproteinases-1	Transforming growth factor beta 1	7076	7040	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Transforming_growth_factor_beta_1 regulates tissue_inhibitor_of_metalloproteinases-1 expression in differentiated human articular chondrocytes .
10409697	0	tissue_inhibitor_of_metalloproteinases-2	78,118	TIMP-2	120,126	tissue inhibitor of metalloproteinases-2	TIMP-2	7077	7077	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biophysical and functional characterization of full-length , recombinant human tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- produced in Escherichia_coli .
16043896	0	tissue_inhibitor_of_metalloproteinases-2	22,62	TIMP-2	64,70	tissue inhibitor of metalloproteinases-2	TIMP-2	21858(Tax:10090)	21858(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Beneficial effects of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- on chronic_dermatitis .
7490456	0	tissue_inhibitor_of_metalloproteinases-2	17,57	TIMP-2	59,65	tissue inhibitor of metalloproteinases-2	TIMP-2	29543(Tax:10116)	29543(Tax:10116)	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in experimental animals using monoclonal antibodies against TIMP-2-specific oligopeptides .
8761971	0	tissue_inhibitor_of_metalloproteinases-2	20,60	TIMP-2	62,68	tissue inhibitor of metalloproteinases-2	TIMP-2	7077	7077	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	The distribution of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in the human placenta .
8886690	0	tissue_inhibitor_of_metalloproteinases-2	36,76	TIMP-2	78,84	tissue inhibitor of metalloproteinases-2	TIMP-2	7077	7077	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- in first trimester human placental decidua .
9872597	0	tissue_inhibitor_of_metalloproteinases-2	119,159	TIMP-2	161,167	tissue inhibitor of metalloproteinases-2	TIMP-2	7077	7077	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of matrix_metalloproteinase-2 -LRB- gelatinase A , MMP-2 -RRB- , membrane-type_matrix_metalloproteinase-1 -LRB- MT1-MMP -RRB- and tissue_inhibitor_of_metalloproteinases-2 -LRB- TIMP-2 -RRB- expression by elastin-derived peptides in human HT-1080 fibrosarcoma cell line .
10830727	0	tissue_inhibitor_of_metalloproteinases-2	75,115	U87	141,144	tissue inhibitor of metalloproteinases-2	U87	7077	641648	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Antitumoral effects of defective_herpes_simplex_virus-mediated transfer of tissue_inhibitor_of_metalloproteinases-2 gene in malignant_glioma U87 in vitro : consequences for anti-cancer gene therapy .
11353449	0	tissue_inhibitor_of_metalloproteinases-3	45,85	TIMP-3	87,93	tissue inhibitor of metalloproteinases-3	TIMP-3	7078	7078	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Systematic search for mutations in the human tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- gene on chromosome 22 and association study with schizophrenia .
9006089	0	tissue_inhibitor_of_metalloproteinases-3	77,117	TIMP-3	119,125	tissue inhibitor of metalloproteinases-3	TIMP-3	21859(Tax:10090)	21859(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of a putative p53 binding site in the promoter of the mouse tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- gene : TIMP-3 is not a p53 target gene .
9540985	0	tissue_inhibitor_of_metalloproteinases-3	14,54	TIMP-3	56,62	tissue inhibitor of metalloproteinases-3	TIMP-3	7078	7078	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Activation of tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP-3 -RRB- mRNA expression in scleroderma skin fibroblasts .
9573343	0	tissue_inhibitor_of_metalloproteinases-3	40,80	TIMP3	82,87	tissue inhibitor of metalloproteinases-3	TIMP3	373596(Tax:8355)	373596(Tax:8355)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Cloning and developmental regulation of tissue_inhibitor_of_metalloproteinases-3 -LRB- TIMP3 -RRB- in Xenopus_laevis early embryos .
8985117	0	tissue_inhibitor_of_metalloproteinases-3	14,54	transforming_growth_factor-beta	74,105	tissue inhibitor of metalloproteinases-3	transforming growth factor-beta	282094(Tax:9913)	7040	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of tissue_inhibitor_of_metalloproteinases-3 gene expression by transforming_growth_factor-beta and dexamethasone in bovine and human articular chondrocytes .
18471442	0	tissue_inhibitor_of_metalloproteinases-3	49,89	transforming_growth_factor_beta	104,135	tissue inhibitor of metalloproteinases-3	transforming growth factor beta	7078	7040	Gene	Gene	regulation|amod|START_ENTITY regulation|nmod|END_ENTITY	Smad signaling pathway is a pivotal component of tissue_inhibitor_of_metalloproteinases-3 regulation by transforming_growth_factor_beta in human chondrocytes .
11988080	0	tissue_inhibitor_of_metalloproteinases-4	80,120	Timp-4	122,128	tissue inhibitor of metalloproteinases-4	Timp-4	110595(Tax:10090)	110595(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of an initiator-like element essential for the expression of the tissue_inhibitor_of_metalloproteinases-4 -LRB- Timp-4 -RRB- gene .
15386409	0	tissue_inhibitor_of_metalloproteinases_1	16,56	TIMP-1	58,64	tissue inhibitor of metalloproteinases 1	TIMP-1	7076	7076	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of tissue_inhibitor_of_metalloproteinases_1 -LRB- TIMP-1 -RRB- in human colorectal_adenoma and adenocarcinoma .
9182725	0	tissue_inhibitor_of_metalloproteinases_1	38,78	TIMP-1	80,86	tissue inhibitor of metalloproteinases 1	TIMP-1	7076	7076	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional activity of the human tissue_inhibitor_of_metalloproteinases_1 -LRB- TIMP-1 -RRB- gene in fibroblasts involves elements in the promoter , exon 1 and intron 1 .
15203191	0	tissue_inhibitor_of_metalloproteinases_3	46,86	Transforming_growth_factor_Beta1	0,32	tissue inhibitor of metalloproteinases 3	Transforming growth factor Beta1	7078	7040	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Transforming_growth_factor_Beta1 induction of tissue_inhibitor_of_metalloproteinases_3 in articular chondrocytes is mediated by reactive oxygen species .
20164040	0	tissue_inhibitors_of_metalloproteinase_1	14,54	TIMP-1	56,62	tissue inhibitors of metalloproteinase 1	TIMP-1	7076	7076	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of tissue_inhibitors_of_metalloproteinase_1 -LRB- TIMP-1 -RRB- in gastric_cancer tissue .
11311239	0	tissue_inhibitors_of_metalloproteinases	41,80	ADAMTS4	14,21	tissue inhibitors of metalloproteinases	ADAMTS4	7076	9507	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of ADAMTS4 -LRB- aggrecanase-1 -RRB- by tissue_inhibitors_of_metalloproteinases -LRB- TIMP-1 , _ 2 , _ 3_and_4 -RRB- .
20210014	0	tissue_inhibitors_of_metalloproteinases	11,50	TIMP	52,56	tissue inhibitors of metalloproteinases	TIMP	7076	7076	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of tissue_inhibitors_of_metalloproteinases -LRB- TIMP -RRB- on course and prognosis of head_and_neck_squamous_cell_carcinoma -RSB- .
11311239	0	tissue_inhibitors_of_metalloproteinases	41,80	aggrecanase-1	23,36	tissue inhibitors of metalloproteinases	aggrecanase-1	7076	9507	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition of ADAMTS4 -LRB- aggrecanase-1 -RRB- by tissue_inhibitors_of_metalloproteinases -LRB- TIMP-1 , _ 2 , _ 3_and_4 -RRB- .
8898012	0	tissue_kallikrein	55,72	kininogen	27,36	tissue kallikrein	kininogen	292855(Tax:10116)	288001(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	High-salt diet upregulates kininogen and downregulates tissue_kallikrein expression in Dahl-SS and SHR rats .
22016393	0	tissue_metalloproteinase_inhibitor_1	84,120	Hyaluronan_synthase_2	0,21	tissue metalloproteinase inhibitor 1	Hyaluronan synthase 2	7076	3037	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	Hyaluronan_synthase_2 -LRB- HAS2 -RRB- promotes breast_cancer cell invasion by suppression of tissue_metalloproteinase_inhibitor_1 -LRB- TIMP-1 -RRB- .
10373228	0	tissue_plasminogen_activator	22,50	Bradykinin	0,10	tissue plasminogen activator	Bradykinin	100128998	3827	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Bradykinin stimulates tissue_plasminogen_activator release in human vasculature .
11056091	0	tissue_plasminogen_activator	22,50	Bradykinin	0,10	tissue plasminogen activator	Bradykinin	100128998	3827	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Bradykinin stimulates tissue_plasminogen_activator release from human forearm vasculature through B -LRB- 2 -RRB- receptor-dependent , NO synthase-independent , and cyclooxygenase-independent pathway .
11345366	0	tissue_plasminogen_activator	37,65	Bradykinin	0,10	tissue plasminogen activator	Bradykinin	100128998	3827	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Bradykinin stimulates the release of tissue_plasminogen_activator in human coronary circulation : effects of angiotensin-converting_enzyme inhibitors .
20671252	0	tissue_plasminogen_activator	33,61	Erythropoietin	0,14	tissue plasminogen activator	Erythropoietin	25692(Tax:10116)	24335(Tax:10116)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Erythropoietin in combination of tissue_plasminogen_activator exacerbates brain_hemorrhage when treatment is initiated 6 hours after stroke .
19171142	0	tissue_plasminogen_activator	46,74	Galectin-1	0,10	tissue plasminogen activator	Galectin-1	100128998	3956	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Galectin-1 is a novel functional receptor for tissue_plasminogen_activator in pancreatic_cancer .
11340211	0	tissue_plasminogen_activator	42,70	Insulin	0,7	tissue plasminogen activator	Insulin	100128998	3630	Gene	Gene	resistance|nmod|START_ENTITY resistance|amod|END_ENTITY	Insulin resistance and elevated levels of tissue_plasminogen_activator in first-degree relatives of South Asian patients with ischemic cerebrovascular_disease .
19929406	0	tissue_plasminogen_activator	79,107	PAI-1	15,20	tissue plasminogen activator	PAI-1	100128998	5054	Gene	Gene	levels|compound|START_ENTITY Association|dep|levels Association|nmod|polymorphisms polymorphisms|amod|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphisms and changes in PAI-1 / tissue_plasminogen_activator levels in myocardial_infarction : a case-control study .
19929406	0	tissue_plasminogen_activator	79,107	PAI-1	73,78	tissue plasminogen activator	PAI-1	100128998	5054	Gene	Gene	levels|compound|START_ENTITY Association|dep|levels Association|nmod|polymorphisms polymorphisms|nmod|END_ENTITY	Association of PAI-1 4G/5G and -844 G/A gene polymorphisms and changes in PAI-1 / tissue_plasminogen_activator levels in myocardial_infarction : a case-control study .
2124638	0	tissue_plasminogen_activator	41,69	PAI-1	127,132	tissue plasminogen activator	PAI-1	100128998	5054	Gene	Gene	activity|nmod|START_ENTITY correlation|nmod|activity -LSB-|dobj|correlation -RSB-|advcl|-LSB- -RSB-|nsubj|levels levels|nmod|antigen antigen|appos|END_ENTITY	-LSB- The correlation between the activity of tissue_plasminogen_activator -LRB- TPA -RRB- , levels of tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- antigen and serum lipids in healthy subjects -RSB- .
2124638	0	tissue_plasminogen_activator	87,115	PAI-1	127,132	tissue plasminogen activator	PAI-1	100128998	5054	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	-LSB- The correlation between the activity of tissue_plasminogen_activator -LRB- TPA -RRB- , levels of tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- antigen and serum lipids in healthy subjects -RSB- .
8965977	0	tissue_plasminogen_activator	41,69	PAI-1	81,86	tissue plasminogen activator	PAI-1	100128998	5054	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|appos|END_ENTITY	-LSB- Tissue_plasminogen_activator _ -LRB- T-PA -RRB- and tissue_plasminogen_activator inhibitor -LRB- PAI-1 -RRB- in patients after head_injury -RSB- .
9264480	0	tissue_plasminogen_activator	13,41	PAI-1	171,176	tissue plasminogen activator	PAI-1	100128998	5054	Gene	Gene	Clearance|nmod|START_ENTITY Clearance|dep|relationship relationship|nmod|patients patients|nmod|levels levels|compound|END_ENTITY	Clearance of tissue_plasminogen_activator -LRB- TPA -RRB- and TPA/plasminogen _ activator_inhibitor_type_1 -LRB- PAI-1 -RRB- complex : relationship to elevated TPA antigen in patients with high PAI-1 activity levels .
22245243	0	tissue_plasminogen_activator	15,43	PDE4	0,4	tissue plasminogen activator	PDE4	100128998	5141	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	PDE4 regulates tissue_plasminogen_activator expression of human brain microvascular endothelial cells .
2501229	0	tissue_plasminogen_activator	29,57	Thrombin	0,8	tissue plasminogen activator	Thrombin	281407(Tax:9913)	280685(Tax:9913)	Gene	Gene	release|nmod|START_ENTITY enhances|dobj|release enhances|nsubj|END_ENTITY	Thrombin enhances release of tissue_plasminogen_activator from bovine corneal endothelial cells .
6542570	0	tissue_plasminogen_activator	20,48	Thrombin	0,8	tissue plasminogen activator	Thrombin	100128998	2147	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Thrombin stimulates tissue_plasminogen_activator release from cultured human endothelial cells .
8880017	0	tissue_plasminogen_activator	30,58	Tissue_plasminogen_activator	0,28	tissue plasminogen activator	Tissue plasminogen activator	100128998	100128998	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Tissue_plasminogen_activator , tissue_plasminogen_activator inhibitor and lipoprotein -LRB- a -RRB- in patients with coronary , epiaortic and peripheral_occlusive_artery_disease .
15055254	0	tissue_plasminogen_activator	92,120	bradykinin	136,146	tissue plasminogen activator	bradykinin	100128998	3827	Gene	Gene	release|nmod|START_ENTITY modulates|dobj|release modulates|nmod|END_ENTITY	Angiotensin-converting_enzyme insertion/deletion polymorphism modulates coronary release of tissue_plasminogen_activator in response to bradykinin .
21615740	0	tissue_plasminogen_activator	28,56	brain-derived_neurotrophic_factor	60,93	tissue plasminogen activator	brain-derived neurotrophic factor	100128998	627	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Zinc-triggered induction of tissue_plasminogen_activator by brain-derived_neurotrophic_factor and metalloproteinases .
2107597	0	tissue_plasminogen_activator	29,57	fibrinogen	15,25	tissue plasminogen activator	fibrinogen	100128998	2244	Gene	Gene	Degradation|nmod|START_ENTITY Degradation|nmod|END_ENTITY	Degradation of fibrinogen by tissue_plasminogen_activator .
21174006	0	tissue_plasminogen_activator	12,40	neuroserpin	51,62	tissue plasminogen activator	neuroserpin	100128998	5274	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|amod|END_ENTITY	The natural tissue_plasminogen_activator inhibitor neuroserpin and acute ischaemic_stroke outcome .
26528129	0	tissue_plasminogen_activator	40,68	neuroserpin	87,98	tissue plasminogen activator	neuroserpin	100128998	5274	Gene	Gene	roles|nmod|START_ENTITY END_ENTITY|nsubj|roles	Physiological and pathological roles of tissue_plasminogen_activator and its inhibitor neuroserpin in the nervous system .
11138573	0	tissue_plasminogen_activator	44,72	plasminogen_activator_inhibitor-1	112,145	tissue plasminogen activator	plasminogen activator inhibitor-1	100128998	5054	Gene	Gene	/|nsubj|START_ENTITY /|dobj|complexes complexes|amod|END_ENTITY	Acute psychological_stress_decreases plasma tissue_plasminogen_activator -LRB- tPA -RRB- and tissue_plasminogen_activator / plasminogen_activator_inhibitor-1 -LRB- tPA/PAI -1 -RRB- complexes in cardiac patients .
11570875	0	tissue_plasminogen_activator	148,176	plasminogen_activator_inhibitor-1	108,141	tissue plasminogen activator	plasminogen activator inhibitor-1	100128998	5054	Gene	Gene	Resolution|nmod|START_ENTITY Resolution|amod|END_ENTITY	Resolution of Michaelis complex , acylation , and conformational change steps in the reactions of the serpin , plasminogen_activator_inhibitor-1 , with tissue_plasminogen_activator and trypsin .
18922856	0	tissue_plasminogen_activator	29,57	plasminogen_activator_inhibitor-1	80,113	tissue plasminogen activator	plasminogen activator inhibitor-1	100128998	5054	Gene	Gene	dynamics|nmod|START_ENTITY Unique|dobj|dynamics Unique|nmod|cells cells|amod|END_ENTITY	Unique secretory dynamics of tissue_plasminogen_activator and its modulation by plasminogen_activator_inhibitor-1 in vascular endothelial cells .
1951323	0	tissue_plasminogen_activator	20,48	plasminogen_activator_inhibitor-1	60,93	tissue plasminogen activator	plasminogen activator inhibitor-1	100128998	5054	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|END_ENTITY	Increased levels of tissue_plasminogen_activator with a low plasminogen_activator_inhibitor-1 in a patient with postoperative_bleeding .
21193004	0	tissue_plasminogen_activator	23,51	plasminogen_activator_inhibitor-1	149,182	tissue plasminogen activator	plasminogen activator inhibitor-1	25692(Tax:10116)	24617(Tax:10116)	Gene	Gene	activity|compound|START_ENTITY regulation|nmod|activity regulation|dep|role role|nmod|END_ENTITY	Biphasic regulation of tissue_plasminogen_activator activity in ischemic rat brain and in cultured neural cells : essential role of astrocyte-derived plasminogen_activator_inhibitor-1 .
3139401	0	tissue_plasminogen_activator	66,94	plasminogen_activator_inhibitor-1	18,51	tissue plasminogen activator	plasminogen activator inhibitor-1	100128998	5054	Gene	Gene	mutants|nmod|START_ENTITY END_ENTITY|nmod|mutants	Neutralization by plasminogen_activator_inhibitor-1 of mutants of tissue_plasminogen_activator .
9136968	0	tissue_plasminogen_activator	38,66	plasminogen_activator_inhibitor-1	89,122	tissue plasminogen activator	plasminogen activator inhibitor-1	100128998	5054	Gene	Gene	alpha2-macroglobulin|nmod|START_ENTITY Protection|nmod|alpha2-macroglobulin Protection|nmod|END_ENTITY	Protection by alpha2-macroglobulin of tissue_plasminogen_activator against inhibition by plasminogen_activator_inhibitor-1 .
14529669	0	tissue_plasminogen_activator	42,70	tPA	72,75	tissue plasminogen activator	tPA	100128998	100128998	Gene	Gene	concentration|nmod|START_ENTITY concentration|appos|END_ENTITY	High preoperative plasma concentration of tissue_plasminogen_activator -LRB- tPA -RRB- is an independent marker for shorter overall survival in patients with ovarian_cancer .
14690546	0	tissue_plasminogen_activator	15,43	tPA	45,48	tissue plasminogen activator	tPA	100128998	100128998	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	High levels of tissue_plasminogen_activator -LRB- tPA -RRB- antigen precede the development of type 2 diabetes in a longitudinal population study .
23906635	0	tissue_plasminogen_activator	40,68	tPA	70,73	tissue plasminogen activator	tPA	18791(Tax:10090)	18791(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Dopamine_D3_receptor deletion increases tissue_plasminogen_activator -LRB- tPA -RRB- activity in prefrontal cortex and hippocampus .
24152103	0	tissue_plasminogen_activator	20,48	tPA	50,53	tissue plasminogen activator	tPA	100128998	100128998	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production of human tissue_plasminogen_activator -LRB- tPA -RRB- in Cucumis_sativus .
9684808	0	tissue_plasminogen_activator	98,126	thrombin	58,66	tissue plasminogen activator	thrombin	25692(Tax:10116)	29251(Tax:10116)	Gene	Gene	combination|nmod|START_ENTITY BCH-2763|nmod|combination BCH-2763|appos|inhibitor inhibitor|compound|END_ENTITY	Effective use of BCH-2763 , a new potent injectable direct thrombin inhibitor , in combination with tissue_plasminogen_activator -LRB- tPA -RRB- in a rat arterial thrombolysis model .
2346288	0	tissue_polypeptide_antigen	16,42	TPA	44,47	tissue polypeptide antigen	TPA	5327	5327	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Significance of tissue_polypeptide_antigen -LRB- TPA -RRB- levels in nasopharyngeal_cancer .
3908587	0	tissue_polypeptide_antigen	36,62	TPA	64,67	tissue polypeptide antigen	TPA	5327	5327	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immuno-histological localization of tissue_polypeptide_antigen -LRB- TPA -RRB- in gynecological malignancies .
6721513	0	tissue_polypeptide_antigen	21,47	TPA	49,52	tissue polypeptide antigen	TPA	5327	5327	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	-LSB- Evaluation of serum tissue_polypeptide_antigen -LRB- TPA -RRB- in patients with urogenital_cancer -RSB- .
7317745	0	tissue_polypeptide_antigen	29,55	TPA	57,60	tissue polypeptide antigen	TPA	5327	5327	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The clinical significance of tissue_polypeptide_antigen -LRB- TPA -RRB- in the urine of bladder_cancer patients .
2887447	0	tissue_transglutaminase	51,74	Beta_B1_crystallin	0,18	tissue transglutaminase	Beta B1 crystallin	281528(Tax:9913)	282205(Tax:9913)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Beta_B1_crystallin is an amine-donor substrate for tissue_transglutaminase .
9541024	0	tissue_transglutaminase	52,75	C-CAM	27,32	tissue transglutaminase	C-CAM	21817(Tax:10090)	26365(Tax:10090)	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	The cell adhesion molecule C-CAM is a substrate for tissue_transglutaminase .
16757564	0	tissue_transglutaminase	53,76	GPR56	0,5	tissue transglutaminase	GPR56	7052	9289	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	GPR56 , an atypical G protein-coupled receptor , binds tissue_transglutaminase , TG2 , and inhibits melanoma_tumor growth and metastasis .
16757564	0	tissue_transglutaminase	53,76	GPR56	0,5	tissue transglutaminase	GPR56	7052	9289	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	GPR56 , an atypical G protein-coupled receptor , binds tissue_transglutaminase , TG2 , and inhibits melanoma_tumor growth and metastasis .
23454274	0	tissue_transglutaminase	41,64	Protein_kinase_C_delta	0,22	tissue transglutaminase	Protein kinase C delta	7052	5580	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Protein_kinase_C_delta is a substrate of tissue_transglutaminase and a novel autoantigen in coeliac_disease .
21046178	0	tissue_transglutaminase	12,35	TG2	37,40	tissue transglutaminase	TG2	21817(Tax:10090)	21817(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of tissue_transglutaminase -LRB- TG2 -RRB- in regulating the tumour progression of the mouse colon_carcinoma CT26 .
2867824	0	tissue_transglutaminase	14,37	THP-1	70,75	tissue transglutaminase	THP-1	7052	2736	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Expression of tissue_transglutaminase in cultured monocytic_leukemia -LRB- THP-1 -RRB- cells during differentiation .
15469694	0	tissue_transglutaminase	19,42	TNF-alpha	72,81	tissue transglutaminase	TNF-alpha	7052	7124	Gene	Gene	role|nmod|START_ENTITY induced|nsubj|role induced|nmod|END_ENTITY	Protective role of tissue_transglutaminase in the cell death induced by TNF-alpha in SH-SY5Y neuroblastoma cells .
19931242	0	tissue_transglutaminase	35,58	angiocidin	19,29	tissue transglutaminase	angiocidin	7052	5710	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of angiocidin with tissue_transglutaminase .
6166622	0	tissue_transglutaminase	45,68	beta_2-microglobulin	6,26	tissue transglutaminase	beta 2-microglobulin	7052	567	Gene	Gene	substrate|nmod|START_ENTITY substrate|nsubj|END_ENTITY	Human beta_2-microglobulin is a substrate of tissue_transglutaminase : polymerization in solution and on the cell surface .
15272014	0	tissue_transglutaminase	16,39	epidermal_growth_factor	69,92	tissue transglutaminase	epidermal growth factor	7052	1950	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Augmentation of tissue_transglutaminase expression and activation by epidermal_growth_factor inhibit doxorubicin-induced apoptosis in human breast_cancer cells .
21896482	0	tissue_transglutaminase	64,87	heat_shock_protein_70	18,39	tissue transglutaminase	heat shock protein 70	7052	3308	Gene	Gene	START_ENTITY|nsubj|role role|nmod|END_ENTITY	A unique role for heat_shock_protein_70 and its binding partner tissue_transglutaminase in cancer cell migration .
10100610	0	tissue_transglutaminase	15,38	importin-alpha3	70,85	tissue transglutaminase	importin-alpha3	7052	3839	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of tissue_transglutaminase with nuclear transport protein importin-alpha3 .
16696340	0	tissue_transglutaminase	21,44	tTG	46,49	tissue transglutaminase	tTG	281528(Tax:9913)	281528(Tax:9913)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of tissue_transglutaminase -LRB- tTG -RRB- antisense oligodeoxynucleotides on tTG expression in cultured bovine trabecular meshwork cells .
16696340	0	tissue_transglutaminase	21,44	tTG	46,49	tissue transglutaminase	tTG	281528(Tax:9913)	281528(Tax:9913)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Inhibitory effect of tissue_transglutaminase -LRB- tTG -RRB- antisense oligodeoxynucleotides on tTG expression in cultured bovine trabecular meshwork cells .
19654435	0	tissue_transglutaminase	16,39	tTG	41,44	tissue transglutaminase	tTG	21817(Tax:10090)	21817(Tax:10090)	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of tissue_transglutaminase -LRB- tTG -RRB- in kidney of ICR-derived_glomerulonephritis -LRB- ICGN -RRB- mice .
11597946	0	tissue_transglutaminase	21,44	tissue_transglutaminase	88,111	tissue transglutaminase	tissue transglutaminase	7052	7052	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Thrombin upregulates tissue_transglutaminase in endothelial cells : a potential role for tissue_transglutaminase in stability of atherosclerotic_plaque .
11597946	0	tissue_transglutaminase	88,111	tissue_transglutaminase	21,44	tissue transglutaminase	tissue transglutaminase	7052	7052	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Thrombin upregulates tissue_transglutaminase in endothelial cells : a potential role for tissue_transglutaminase in stability of atherosclerotic_plaque .
16044913	0	titin	23,28	Cyclosporin_a	1,14	titin	Cyclosporin a	7273	1161	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	-LSB- Cyclosporin_a induces titin expression in human trophoblast cells through the MEK/ERK1/2 signal pathway -RSB- .
11927605	0	titin	45,50	Muscle-specific_RING_finger-1	0,29	titin	Muscle-specific RING finger-1	7273	84676	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Muscle-specific_RING_finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid_modulatory_element_binding_protein-1 .
23975875	0	titin	21,26	TTN	33,36	titin	TTN	7273	7273	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Recessive truncating titin gene , TTN , mutations presenting as centronuclear_myopathy .
10819994	0	titin	28,33	alpha-actinin	11,24	titin	alpha-actinin	7273	87	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of alpha-actinin to titin : implications for Z-disk assembly .
3320056	2	titin	125,130	alpha-actinin	99,112	titin	alpha-actinin	424126(Tax:9031)	396024(Tax:9031)	Gene	Gene	dots|nmod|START_ENTITY dots|amod|END_ENTITY	Generation of alpha-actinin dots within titin spots at the time of the first myofibril formation .
9245597	0	titin	78,83	alpha-actinin	31,44	titin	alpha-actinin	7273	87	Gene	Gene	properties|nmod|START_ENTITY properties|amod|END_ENTITY	Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin : implications for the nature of vertebrate Z-discs .
9438132	0	titin	43,48	alpha-actinin	15,28	titin	alpha-actinin	7273	87	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of alpha-actinin with cellular titin .
9501083	0	titin	59,64	alpha-actinin	113,126	titin	alpha-actinin	7273	87	Gene	Gene	interactions|compound|START_ENTITY types|nmod|interactions Z-disk|dep|types structure|nmod|Z-disk lead|nsubj|structure lead|nmod|asymmetrical asymmetrical|nmod|END_ENTITY	Molecular structure of the sarcomeric Z-disk : two types of titin interactions lead to an asymmetrical sorting of alpha-actinin .
11945023	0	titin	101,106	alpha_B-crystallin	51,69	titin	alpha B-crystallin	84015(Tax:10116)	25420(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Ischemia-induced association of the stress protein alpha_B-crystallin with I-band portion of cardiac titin .
1527215	0	titin	42,47	connectin	31,40	titin	connectin	7273	7273	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization and elasticity of connectin -LRB- titin -RRB- filaments in skinned frog muscle fibres subjected to partial depolymerization of thick filaments .
2592979	0	titin	35,40	connectin	24,33	titin	connectin	7273	7273	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	Immunochemical study of connectin -LRB- titin -RRB- in neuromuscular_diseases using a monoclonal antibody : connectin is degraded extensively in Duchenne_muscular_dystrophy .
11037792	0	titin	37,42	nebulin	14,21	titin	nebulin	7273	4703	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of nebulin and connectin -LRB- titin -RRB- for assembly of actin filaments during myofibrillogenesis .
17266438	0	tlr3	49,53	pkr	57,60	tlr3	pkr	142980(Tax:10090)	19106(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Enlarged spleens without enlarged lymph nodes in tlr3 - / - pkr - / - mice .
18330929	0	tmie	29,33	transmembrane_inner_ear	4,27	tmie	transmembrane inner ear	555430(Tax:7955)	555430(Tax:7955)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	The transmembrane_inner_ear -LRB- tmie -RRB- gene contributes to vestibular and lateral line development and function in the zebrafish -LRB- Danio_rerio -RRB- .
21607299	0	tnf-alpha	96,105	icam-1	37,43	tnf-alpha	icam-1	7124	3383	Gene	Gene	treatment|nmod|START_ENTITY Shedding|nmod|treatment Shedding|nmod|molecules molecules|amod|END_ENTITY	Shedding of tnf-receptor and soluble icam-1 molecules in response to treatment with recombinant tnf-alpha and IFN-gamma in patients with colorectal-cancer .
24802997	0	tnfr2	23,28	Tnfa	0,4	tnfr2	Tnfa	7133	7124	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation .
17068331	0	toll	2,6	Toll5A	32,38	toll	Toll5A	43222(Tax:7227)	5569408(Tax:7159)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	A toll receptor and a cytokine , Toll5A and Spz1C , are involved in toll antifungal immune signaling in the mosquito Aedes_aegypti .
17068331	0	toll	66,70	Toll5A	32,38	toll	Toll5A	43222(Tax:7227)	5569408(Tax:7159)	Gene	Gene	signaling|nsubj|START_ENTITY involved|advcl|signaling involved|nsubjpass|receptor receptor|appos|END_ENTITY	A toll receptor and a cytokine , Toll5A and Spz1C , are involved in toll antifungal immune signaling in the mosquito Aedes_aegypti .
20580721	0	toll-like_receptor-4	53,73	Nucleotide-binding_oligomerization_domain-2	0,43	toll-like receptor-4	Nucleotide-binding oligomerization domain-2	21898(Tax:10090)	257632(Tax:10090)	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	Nucleotide-binding_oligomerization_domain-2 inhibits toll-like_receptor-4 signaling in the intestinal epithelium .
16433852	0	toll-like_receptor-4	66,86	Signal_transducer_and_activator_of_transcription_6	0,50	toll-like receptor-4	Signal transducer and activator of transcription 6	7099	6778	Gene	Gene	expression|amod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Signal_transducer_and_activator_of_transcription_6 down-regulates toll-like_receptor-4 expression of a monocytic cell line .
25280922	0	toll-like_receptor-4	35,55	TLR-4	57,62	toll-like receptor-4	TLR-4	7099	7099	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Evaluation of four a-diketones for toll-like_receptor-4 -LRB- TLR-4 -RRB- activation in a human transfected cell line .
16870179	0	toll-like_receptor-9	14,34	Akt	89,92	toll-like receptor-9	Akt	54106	207	Gene	Gene	Activation|nmod|START_ENTITY induces|nsubj|Activation induces|nmod|END_ENTITY	Activation of toll-like_receptor-9 induces matrix_metalloproteinase-9 expression through Akt and tumor_necrosis_factor-alpha signaling .
15142865	0	toll-like_receptor_2	13,33	A20	0,3	toll-like receptor 2	A20	7097	7128	Gene	Gene	synthesis|amod|START_ENTITY inhibits|dobj|synthesis inhibits|nsubj|END_ENTITY	A20 inhibits toll-like_receptor_2 - and 4-mediated interleukin-8 synthesis in airway epithelial cells .
15388451	0	toll-like_receptor_2	62,82	NF-kappaB	108,117	toll-like receptor 2	NF-kappaB	7097	4790	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Human_immunodeficiency_virus_type_1 protease inhibitors block toll-like_receptor_2 -LRB- TLR2 -RRB- - and TLR4-Induced NF-kappaB activation .
15190028	0	toll-like_receptor_2	45,65	TLR2	67,71	toll-like receptor 2	TLR2	7097	7097	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	The glycopeptide vancomycin does not enhance toll-like_receptor_2 -LRB- TLR2 -RRB- activation by Streptococcus_pneumoniae .
18096121	0	toll-like_receptor_2	14,34	TLR2	36,40	toll-like receptor 2	TLR2	24088(Tax:10090)	24088(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of toll-like_receptor_2 -LRB- TLR2 -RRB- in porcine leukocyte subsets and tissues .
25180613	0	toll-like_receptor_2	39,59	TLR2	61,65	toll-like receptor 2	TLR2	7097	7097	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms in the toll-like_receptor_2 -LRB- TLR2 -RRB- gene are associated with microscopic_polyangiitis in the northern Han Chinese population .
17460566	0	toll-like_receptor_2	45,65	angiotensin_II	13,27	toll-like receptor 2	angiotensin II	310553(Tax:10116)	24179(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of angiotensin_II on expression of toll-like_receptor_2 and maturation of dendritic cells in chronic cyclosporine nephropathy .
22350388	0	toll-like_receptor_2	14,34	interleukin-10	55,69	toll-like receptor 2	interleukin-10	7097	3586	Gene	Gene	level|amod|START_ENTITY level|nmod|END_ENTITY	Expression of toll-like_receptor_2 and plasma level of interleukin-10 are associated with outcome in tuberculosis .
19472082	0	toll-like_receptor_3	8,28	IL-8	79,83	toll-like receptor 3	IL-8	7098	3576	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of toll-like_receptor_3 , RIG-I , and MDA5 in the expression of mesothelial IL-8 induced by viral RNA .
21822148	0	toll-like_receptor_4	68,88	AT1_receptor	6,18	toll-like receptor 4	AT1 receptor	21898(Tax:10090)	11610(Tax:10090)	Gene	Gene	activates|nmod|START_ENTITY activates|nsubj|END_ENTITY	Brain AT1_receptor activates the sympathetic nervous system through toll-like_receptor_4 in mice with heart_failure .
18992185	0	toll-like_receptor_4	24,44	Angiotensin_II	1,15	toll-like receptor 4	Angiotensin II	21898(Tax:10090)	11606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	-LSB- Angiotensin_II induces toll-like_receptor_4 expression and myeloperoxidase activity in RAW264 .7 cells -RSB- .
20580035	0	toll-like_receptor_4	85,105	C-reactive_protein	56,74	toll-like receptor 4	C-reactive protein	7099	1401	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Adding exercise to rosuvastatin treatment : influence on C-reactive_protein , monocyte toll-like_receptor_4 expression , and inflammatory monocyte -LRB- CD14 + CD16 + -RRB- population .
24813219	0	toll-like_receptor_4	36,56	CCL2	104,108	toll-like receptor 4	CCL2	281536(Tax:9913)	281043(Tax:9913)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genetic polymorphisms in the bovine toll-like_receptor_4 -LRB- TLR4 -RRB- and monocyte chemo attractant protein-1 -LRB- CCL2 -RRB- genes : SNPs distribution analysis in Bos_indicus Sahiwal cattle breed .
12404174	0	toll-like_receptor_4	6,26	CD14	45,49	toll-like receptor 4	CD14	7099	929	Gene	Gene	mutations|amod|START_ENTITY mutations|nmod|polymorphisms polymorphisms|nummod|END_ENTITY	Human toll-like_receptor_4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections .
18976692	0	toll-like_receptor_4	33,53	CD14	25,29	toll-like receptor 4	CD14	21898(Tax:10090)	12475(Tax:10090)	Gene	Gene	neuropathic_pain|amod|START_ENTITY role|nmod|neuropathic_pain role|nmod|END_ENTITY	The contributing role of CD14 in toll-like_receptor_4 dependent neuropathic_pain .
23508573	0	toll-like_receptor_4	55,75	CD14	100,104	toll-like receptor 4	CD14	7099	929	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nsubj|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
24103748	0	toll-like_receptor_4	58,78	Ephrin-A1	0,9	toll-like receptor 4	Ephrin-A1	7099	1942	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|expression expression|amod|END_ENTITY	Ephrin-A1 expression induced by S100A8 is mediated by the toll-like_receptor_4 .
22574597	0	toll-like_receptor_4	76,96	ICAM-1	163,169	toll-like receptor 4	ICAM-1	7099	3383	Gene	Gene	signal|amod|START_ENTITY signal|acl|transduction transduction|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of yiqi huoxue compound contained drug serum on the expressions of toll-like_receptor_4 and downstream signal transduction pathway , and LOX-1 , TNF-alpha , ICAM-1 in the human vein endothelial cells -RSB- .
26813112	0	toll-like_receptor_4	112,132	Macrophage_migration_inhibitory_factor	0,38	toll-like receptor 4	Macrophage migration inhibitory factor	7099	4282	Gene	Gene	inducing|xcomp|START_ENTITY enhances|advcl|inducing enhances|nsubj|END_ENTITY	Macrophage_migration_inhibitory_factor enhances lipopolysaccharide-induced fibroblast proliferation by inducing toll-like_receptor_4 .
25887269	0	toll-like_receptor_4	69,89	NF-kappaB	90,99	toll-like receptor 4	NF-kappaB	7099	4790	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Daidzein attenuates lipopolysaccharide-induced acute_lung_injury via toll-like_receptor_4 / NF-kappaB pathway .
18174680	0	toll-like_receptor_4	82,102	TLR4	104,108	toll-like receptor 4	TLR4	7099	7099	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	The c.1-260C > T promoter variant of CD14 but not the c. 896A > G -LRB- p.D299G -RRB- variant of toll-like_receptor_4 -LRB- TLR4 -RRB- genes is associated with inflammatory_bowel_disease .
18493843	0	toll-like_receptor_4	29,49	TLR4	51,55	toll-like receptor 4	TLR4	7099	7099	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery and development of toll-like_receptor_4 -LRB- TLR4 -RRB- antagonists : a new paradigm for treating sepsis_and_other_diseases .
22872782	0	toll-like_receptor_4	51,71	TLR4	73,77	toll-like receptor 4	TLR4	7099	7099	Gene	Gene	fusion|amod|START_ENTITY fusion|appos|END_ENTITY	Respiratory_syncytial_virus fusion protein-induced toll-like_receptor_4 -LRB- TLR4 -RRB- signaling is inhibited by the TLR4 antagonists Rhodobacter_sphaeroides lipopolysaccharide and eritoran -LRB- E5564 -RRB- and requires direct interaction with MD-2 .
24259392	0	toll-like_receptor_4	66,86	TLR4	88,92	toll-like receptor 4	TLR4	29260(Tax:10116)	29260(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Epigallocatechin_gallate improves insulin signaling by decreasing toll-like_receptor_4 -LRB- TLR4 -RRB- activity in adipose tissues of high-fat diet rats .
25241065	0	toll-like_receptor_4	64,84	TLR4	86,90	toll-like receptor 4	TLR4	29260(Tax:10116)	29260(Tax:10116)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Activation of adult rat CNS endothelial cells by opioid-induced toll-like_receptor_4 -LRB- TLR4 -RRB- signaling induces proinflammatory , biochemical , morphological , and behavioral sequelae .
15935092	0	toll-like_receptor_4	47,67	TNF-alpha	83,92	toll-like receptor 4	TNF-alpha	29260(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Chlamydophila_pneumoniae induces expression of toll-like_receptor_4 and release of TNF-alpha and MIP-2 via an NF-kappaB pathway in rat type II pneumocytes .
16285897	0	toll-like_receptor_4	144,164	TNF-alpha	98,107	toll-like receptor 4	TNF-alpha	7099	7124	Gene	Gene	pathway|nmod|START_ENTITY not|nmod|pathway elicit|dep|not elicit|dobj|release release|amod|END_ENTITY	Lipopolysaccharide could be internalized into human peripheral blood mononuclear cells and elicit TNF-alpha release , but not via the pathway of toll-like_receptor_4 on the cell surface .
19106809	0	toll-like_receptor_4	19,39	TNF-alpha	0,9	toll-like receptor 4	TNF-alpha	7099	7124	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	TNF-alpha inhibits toll-like_receptor_4 expression on monocytic cells via tristetraprolin during cardiopulmonary bypass .
20550956	0	toll-like_receptor_4	9,29	TNF-alpha	33,42	toll-like receptor 4	TNF-alpha	21898(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Role for toll-like_receptor_4 in TNF-alpha secretion by murine macrophages in response to polysaccharide Krestin , a Trametes versicolor mushroom extract .
22574597	0	toll-like_receptor_4	76,96	TNF-alpha	152,161	toll-like receptor 4	TNF-alpha	7099	7124	Gene	Gene	signal|amod|START_ENTITY signal|acl|transduction transduction|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effects of yiqi huoxue compound contained drug serum on the expressions of toll-like_receptor_4 and downstream signal transduction pathway , and LOX-1 , TNF-alpha , ICAM-1 in the human vein endothelial cells -RSB- .
26346361	0	toll-like_receptor_4	30,50	a-synuclein	10,21	toll-like receptor 4	a-synuclein	7099	6622	Gene	Gene	responses|amod|START_ENTITY induces|dobj|responses induces|nsubj|END_ENTITY	Exogenous a-synuclein induces toll-like_receptor_4 dependent inflammatory responses in astrocytes .
26346361	0	toll-like_receptor_4	30,50	a-synuclein	10,21	toll-like receptor 4	a-synuclein	7099	6622	Gene	Gene	responses|amod|START_ENTITY induces|dobj|responses induces|nsubj|END_ENTITY	Exogenous a-synuclein induces toll-like_receptor_4 dependent inflammatory responses in astrocytes .
23508573	0	toll-like_receptor_4	55,75	high_mobility_group_box_1	13,38	toll-like receptor 4	high mobility group box 1	7099	3146	Gene	Gene	Signaling|nmod|START_ENTITY Signaling|nmod|END_ENTITY	Signaling of high_mobility_group_box_1 -LRB- HMGB1 -RRB- through toll-like_receptor_4 in macrophages requires CD14 .
20887801	0	toll-like_receptor_4	59,79	interleukin_6_and_8	111,130	toll-like receptor 4	interleukin 6 and 8	7099	3569;3576	Gene	Gene	upregulation|amod|START_ENTITY upregulation|nmod|END_ENTITY	Opisthorchis viverrini excretory/secretory products induce toll-like_receptor_4 upregulation and production of interleukin_6_and_8 in cholangiocyte .
21046243	0	toll-like_receptor_4	88,108	interleukin_8	141,154	toll-like receptor 4	interleukin 8	7099	3576	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Small_intestinal_bacterial_overgrowth in nonalcoholic_steatohepatitis : association with toll-like_receptor_4 expression and plasma levels of interleukin_8 .
25979559	0	toll-like_receptor_4	39,59	p38	0,3	toll-like receptor 4	p38	7099	1432	Gene	Gene	pathway|nmod|START_ENTITY pathway|amod|END_ENTITY	p38 and interleukin-1_beta pathway via toll-like_receptor_4 contributed to the skin and muscle incision and retraction-induced allodynia .
18442801	0	toll-like_receptor_4	67,87	peroxiredoxin_II	21,37	toll-like receptor 4	peroxiredoxin II	21898(Tax:10090)	21672(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Differential role of peroxiredoxin_II -LRB- PrxII -RRB- on the expression of toll-like_receptor_4 -LRB- TLR4 -RRB- and B-cell_activating_factor -LRB- BAFF -RRB- in ovalbumin -LRB- OVA -RRB- - induced mouse asthma .
10756091	0	toll-like_receptor_5	43,63	Tlr5	65,69	toll-like receptor 5	Tlr5	53791(Tax:10090)	53791(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of the murine toll-like_receptor_5 -LRB- Tlr5 -RRB- gene : sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice .
19130296	0	toll-like_receptor_9	78,98	TLR9	100,104	toll-like receptor 9	TLR9	54106	54106	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of a single nucleotide polymorphism in the exon 2 region of toll-like_receptor_9 -LRB- TLR9 -RRB- gene with susceptibility to systemic_lupus_erythematosus among Chinese .
26643105	0	toll-like_receptors_2_and_4	55,82	PRG4	113,117	toll-like receptors 2 and 4	PRG4	7097;7099	10216	Gene	Gene	interaction|nmod|START_ENTITY interaction|dep|role role|nmod|END_ENTITY	The interaction of lubricin/proteoglycan _ 4 -LRB- PRG4 -RRB- with toll-like_receptors_2_and_4 : an anti-inflammatory role of PRG4 in synovial fluid .
14563850	0	tollip	54,60	Tom1	0,4	tollip	Tom1	54472	10043	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Tom1 , a VHS domain-containing protein , interacts with tollip , ubiquitin , and clathrin .
8174772	0	tolloid	121,128	bone_morphogenetic_protein-1	30,58	tolloid	bone morphogenetic protein-1	42945(Tax:7227)	12153(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|expression expression|nmod|END_ENTITY	Embryonic expression of mouse bone_morphogenetic_protein-1 -LRB- BMP-1 -RRB- , which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase .
1840509	0	tolloid	46,53	bone_morphogenetic_protein_1	74,102	tolloid	bone morphogenetic protein 1	42945(Tax:7227)	649	Gene	Gene	related|nsubjpass|START_ENTITY related|nmod|END_ENTITY	The Drosophila dorsal-ventral patterning gene tolloid is related to human bone_morphogenetic_protein_1 .
25095751	0	tonoplast_intrinsic_protein	36,63	TIP	65,68	tonoplast intrinsic protein	TIP	10524	10524	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genome-wide comparative analysis of tonoplast_intrinsic_protein -LRB- TIP -RRB- genes in plants .
2555773	0	topoisomerase_1	15,30	HSP_70	77,83	topoisomerase 1	HSP 70	32458(Tax:7227)	44920(Tax:7227)	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Interaction of topoisomerase_1 with the transcribed region of the Drosophila HSP_70 heat_shock gene .
18676842	0	topoisomerase_1	15,30	Par-4	0,5	topoisomerase 1	Par-4	7150	5074	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Par-4 binds to topoisomerase_1 and attenuates its DNA relaxation activity .
25777400	0	topoisomerase_1	149,164	TOP1	166,170	topoisomerase 1	TOP1	7150	7150	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2 - negative breast_cancer and increased copy numbers of the topoisomerase_1 -LRB- TOP1 -RRB- gene : a study protocol .
25885574	0	topoisomerase_1	149,164	TOP1	166,170	topoisomerase 1	TOP1	7150	7150	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2 - negative breast_cancer and increased copy numbers of the topoisomerase_1 -LRB- TOP1 -RRB- gene : a study protocol .
23577133	0	topoisomerase_I	14,29	TOP1	31,35	topoisomerase I	TOP1	7150	7150	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Mechanisms of topoisomerase_I -LRB- TOP1 -RRB- gene copy number increase in a stage III colorectal_cancer patient cohort .
27017547	0	topoisomerase_I	68,83	TopI	85,89	topoisomerase I	TopI	7150	7150	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and biological evaluation of indeno -LSB- 1,5 -RSB- naphthyridines as topoisomerase_I -LRB- TopI -RRB- inhibitors with antiproliferative activity .
24801450	0	topoisomerase_IIb	32,49	Specificity_protein_1	0,21	topoisomerase IIb	Specificity protein 1	7155	6667	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Specificity_protein_1 regulates topoisomerase_IIb expression in SH-SY5Y cells during neuronal differentiation .
23277395	0	topoisomerase_IIb_binding_protein_1	54,89	TopBP1	91,97	topoisomerase IIb binding protein 1	TopBP1	11073	11073	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the c. * 229C > T polymorphism of the topoisomerase_IIb_binding_protein_1 -LRB- TopBP1 -RRB- gene and breast_cancer .
15930383	0	torsinA	43,50	DYT1	60,64	torsinA	DYT1	30931(Tax:10090)	30931(Tax:10090)	Gene	Gene	expressing|dobj|START_ENTITY expressing|nmod|mutation mutation|compound|END_ENTITY	Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation .
19965758	0	torso	64,69	PTTH	24,28	torso	PTTH	35717(Tax:7227)	33238(Tax:7227)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis .
12747415	0	tpi	115,118	triosephosphate_isomerase	88,113	tpi	triosephosphate isomerase	7167	7167	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Genotypic differentiation of twelve Clostridium species by polymorphism analysis of the triosephosphate_isomerase -LRB- tpi -RRB- gene .
17038507	0	trace_amine-associated_receptor1	51,83	TAAR1	142,147	trace amine-associated receptor1	TAAR1	134864	113914(Tax:10116)	Gene	Gene	characterization|nmod|START_ENTITY characterization|nmod|END_ENTITY	Pharmacologic characterization of the cloned human trace_amine-associated_receptor1 -LRB- TAAR1 -RRB- and evidence for species differences with the rat TAAR1 .
18524885	0	trace_amine-associated_receptor_1	61,94	TAAR1	96,101	trace amine-associated receptor 1	TAAR1	134864	134864	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Pharmacological characterization of membrane-expressed human trace_amine-associated_receptor_1 -LRB- TAAR1 -RRB- by a bioluminescence resonance energy transfer cAMP biosensor .
26302754	0	trace_amine-associated_receptor_1	24,57	TAAR1	59,64	trace amine-associated receptor 1	TAAR1	134864	134864	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Methamphetamine induces trace_amine-associated_receptor_1 -LRB- TAAR1 -RRB- expression in human T lymphocytes : role in immunomodulation .
17097106	0	trace_amine_associated_receptor_6	19,52	TAAR6	54,59	trace amine associated receptor 6	TAAR6	319100	319100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the trace_amine_associated_receptor_6 -LRB- TAAR6 -RRB- gene with schizophrenia and bipolar_disorder in a Korean case control sample .
15329799	0	trace_amine_receptor_4	21,43	TRAR4	45,50	trace amine receptor 4	TRAR4	319100	319100	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the trace_amine_receptor_4 -LRB- TRAR4 -RRB- gene on chromosome 6q23 .2 are associated with susceptibility to schizophrenia .
21674298	0	tracheal_antimicrobial_peptide	39,69	oct-1	12,17	tracheal antimicrobial peptide	oct-1	286837(Tax:9913)	519461(Tax:9913)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	The role of oct-1 in the regulation of tracheal_antimicrobial_peptide -LRB- TAP -RRB- and lingual_antimicrobial_peptide -LRB- LAP -RRB- expression in bovine mammary epithelial cells .
9161404	0	tracheo-bronchial_mucin	30,53	TBM	55,58	tracheo-bronchial mucin	TBM	4586	4586	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional regulation of tracheo-bronchial_mucin -LRB- TBM -RRB- gene by ethanol .
10479402	0	trail	27,32	APO-2_ligand	14,26	trail	APO-2 ligand	8743	8743	Gene	Gene	expression|compound|START_ENTITY Regulation|dep|expression Regulation|nmod|END_ENTITY	Regulation of APO-2_ligand / trail expression in NK cells-involvement in NK cell-mediated cytotoxicity .
15123692	0	transactivation-responsive_RNA-binding_protein	43,89	Merlin	0,6	transactivation-responsive RNA-binding protein	Merlin	21357(Tax:10090)	18016(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Merlin , a tumor suppressor , interacts with transactivation-responsive_RNA-binding_protein and inhibits its oncogenic activity .
9339383	0	transaldolase	10,23	TALDO1	30,36	transaldolase	TALDO1	6888	6888	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The human transaldolase gene -LRB- TALDO1 -RRB- is located on chromosome 11 at p15.4-p15 .5 .
19274320	0	transcobalamin_2	79,95	TC2	97,100	transcobalamin 2	TC2	6948	6948	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	A80G polymorphism of reduced folate carrier 1 -LRB- RFC1 -RRB- and C776G polymorphism of transcobalamin_2 -LRB- TC2 -RRB- genes in Down 's _ syndrome etiology .
11287214	0	transcobalamin_II	47,64	intrinsic_factor	27,43	transcobalamin II	intrinsic factor	6948	2694	Gene	Gene	Transfer|nmod|START_ENTITY Transfer|nmod|END_ENTITY	Transfer of cobalamin from intrinsic_factor to transcobalamin_II .
2556942	0	transcobalamin_II	56,73	intrinsic_factor	23,39	transcobalamin II	intrinsic factor	64365(Tax:10116)	29319(Tax:10116)	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Cobalamin release from intrinsic_factor and transfer to transcobalamin_II within the rat enterocyte .
7695633	0	transcobalamin_II	27,44	intrinsic_factor	66,82	transcobalamin II	intrinsic factor	6948	2694	Gene	Gene	structure|nmod|START_ENTITY structure|dep|comparison comparison|nmod|END_ENTITY	Genomic structure of human transcobalamin_II : comparison to human intrinsic_factor and transcobalamin_I .
6812601	0	transcortin	81,92	CBG	94,97	transcortin	CBG	866	866	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	Immunoglobulin levels in breast cyst fluid : apparent connection with intracystic transcortin -LRB- CBG -RRB- binding activity .
24157263	0	transcription_factor-7-like_2	17,46	TCF7L2	48,54	transcription factor-7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms of transcription_factor-7-like_2 -LRB- TCF7L2 -RRB- gene in Tunisian women with polycystic_ovary_syndrome -LRB- PCOS -RRB- .
7490085	0	transcription_factor_3	38,60	TFE3	62,66	transcription factor 3	TFE3	6929	7030	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The genomic organization of the human transcription_factor_3 -LRB- TFE3 -RRB- gene .
23185296	0	transcription_factor_4	51,73	TCF4	75,79	transcription factor 4	TCF4	6925	6925	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A common trinucleotide repeat expansion within the transcription_factor_4 -LRB- TCF4 , E2-2 -RRB- gene predicts Fuchs_corneal_dystrophy .
16936216	0	transcription_factor_7-like_2	11,40	TCF7L2	42,48	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variant of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and the risk of type 2 diabetes in large cohorts of U.S. women and men .
16936218	0	transcription_factor_7-like_2	21,50	TCF7L2	52,58	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene are associated with type 2 diabetes in the Amish : replication and evidence for a role in both insulin secretion and insulin resistance .
17130514	0	transcription_factor_7-like_2	20,49	TCF7L2	51,57	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with reduced insulin secretion in nondiabetic women .
17259383	0	transcription_factor_7-like_2	14,43	TCF7L2	45,51	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Haplotypes of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans .
17342473	0	transcription_factor_7-like_2	17,46	TCF7L2	48,54	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A variant in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with an increased risk of gestational_diabetes_mellitus .
17579206	0	transcription_factor_7-like_2	54,83	TCF7L2	85,91	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of the genetic polymorphisms of the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and type 2 diabetes in the Chinese population .
17601994	0	transcription_factor_7-like_2	16,45	TCF7L2	47,53	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene are associated with type 2 diabetes in an African-American population enriched for nephropathy .
17725629	0	transcription_factor_7-like_2	4,33	TCF7L2	35,41	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with Type 2 diabetes in UK community-based cases , but the risk allele frequency is reduced compared with UK cases selected for genetic studies .
17934151	0	transcription_factor_7-like_2	17,46	TCF7L2	48,54	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A variant of the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and the risk of posttransplantation diabetes_mellitus in renal allograft recipients .
18302196	0	transcription_factor_7-like_2	31,60	TCF7L2	62,68	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evaluation of a variant in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and prostate_cancer risk in a population-based study .
21301999	0	transcription_factor_7-like_2	22,51	TCF7L2	53,59	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variations in transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene : association of TCF7L2 rs12255372 -LRB- G/T -RRB- or rs7903146 -LRB- C/T -RRB- with breast_cancer risk and clinico-pathological parameters .
21399856	0	transcription_factor_7-like_2	12,41	TCF7L2	43,49	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Variants of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene and incident glucose_intolerance in Japanese-Brazilians .
21855162	0	transcription_factor_7-like_2	18,47	TCF7L2	49,55	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- in fat and placental tissue from women with gestational_diabetes .
23855352	0	transcription_factor_7-like_2	45,74	TCF7L2	76,82	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the rs7903146 polymorphism in transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene with gestational_diabetes_mellitus : a meta-analysis .
25934528	0	transcription_factor_7-like_2	20,49	TCF7L2	51,57	transcription factor 7-like 2	TCF7L2	6934	6934	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the transcription_factor_7-like_2 -LRB- TCF7L2 -RRB- gene is associated with impaired_proinsulin_conversion-A meta-analysis .
24770416	0	transcription_factor_EB	63,86	TFEB	88,92	transcription factor EB	TFEB	7942	7942	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	The phytoestrogen genistein modulates lysosomal metabolism and transcription_factor_EB -LRB- TFEB -RRB- activation .
26264650	0	transcription_factor_EB	24,47	TFEB	49,53	transcription factor EB	TFEB	7942	7942	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of transcription_factor_EB -LRB- TFEB -RRB- is associated with autophagy , migratory phenotype and poor prognosis in non-small cell lung_cancer .
9765510	0	transcription_factor_IIB	45,69	aryl_hydrocarbon_receptor	4,29	transcription factor IIB	aryl hydrocarbon receptor	29105	196	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The aryl_hydrocarbon_receptor interacts with transcription_factor_IIB .
9013769	0	transcription_factor_IIB	25,49	vitamin_D_receptor	94,112	transcription factor IIB	vitamin D receptor	29105	7421	Gene	Gene	domain|nmod|START_ENTITY required|nsubjpass|domain required|nmod|END_ENTITY	The N-terminal domain of transcription_factor_IIB is required for direct interaction with the vitamin_D_receptor and participates in vitamin_D-mediated transcription .
22581837	0	transcriptional_intermediary_factor_2	56,93	cyclin_D1	106,115	transcriptional intermediary factor 2	cyclin D1	10499	595	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Nuclear epidermal_growth_factor_receptor interacts with transcriptional_intermediary_factor_2 to activate cyclin_D1 gene expression triggered by the oncoprotein latent_membrane_protein_1 .
22581837	0	transcriptional_intermediary_factor_2	56,93	epidermal_growth_factor_receptor	8,40	transcriptional intermediary factor 2	epidermal growth factor receptor	10499	1956	Gene	Gene	interacts|nmod|START_ENTITY interacts|compound|END_ENTITY	Nuclear epidermal_growth_factor_receptor interacts with transcriptional_intermediary_factor_2 to activate cyclin_D1 gene expression triggered by the oncoprotein latent_membrane_protein_1 .
10333295	0	transferrin	40,51	Butyrylcholinesterase	0,21	transferrin	Butyrylcholinesterase	7018	590	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubjpass|END_ENTITY	Butyrylcholinesterase is complexed with transferrin in chicken serum .
12939601	0	transferrin	40,51	GADD153	60,67	transferrin	GADD153	7018	1649	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells .
10556042	0	transferrin	46,57	HFE	28,31	transferrin	HFE	7018	3077	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	The hemochromatosis protein HFE competes with transferrin for binding to the transferrin_receptor .
1283808	2	transferrin	67,78	Haptoglobin	54,65	transferrin	Haptoglobin	7018	3240	Gene	Gene	protein|dep|START_ENTITY protein|compound|END_ENTITY	Haptoglobin , transferrin , alpha-1-feto protein , alpha-1-acid glycoprotein and caeruloplasmin levels .
7800164	0	transferrin	78,89	IL-2	91,95	transferrin	IL-2	7018	3558	Gene	Gene	START_ENTITY|appos|receptor receptor|amod|END_ENTITY	Psychoimmune investigation in obsessive-compulsive_disorder : assays of plasma transferrin , IL-2 and IL-6 receptor , and IL-1_beta and IL-6 concentrations .
3259477	0	transferrin	28,39	IL_2	74,78	transferrin	IL 2	7018	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|nmod|END_ENTITY	Simultaneous measurement of transferrin receptor and DNA content of human IL_2 dependent T cells by flow cytometry .
19535202	0	transferrin	23,34	Interleukin-18	0,14	transferrin	Interleukin-18	7018	3606	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-18 induces transferrin expression in breast_cancer cell line MCF-7 .
9511831	0	transferrin	43,54	TbpA	128,132	transferrin	TbpA	7018	7276	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|proteins proteins|appos|END_ENTITY	Differential binding of apo and holo human transferrin to meningococci and co-localisation of the transferrin-binding proteins -LRB- TbpA and TbpB -RRB- .
9766237	0	transferrin	110,121	TbpA	78,82	transferrin	TbpA	7018	7276	Gene	Gene	iron|compound|START_ENTITY uptake|nmod|iron Cooperation|nmod|uptake Cooperation|nmod|components components|nmod|receptor receptor|appos|END_ENTITY	Cooperation between the components of the meningococcal transferrin receptor , TbpA and TbpB , in the uptake of transferrin iron by the 37-kDa ferric-binding protein -LRB- FbpA -RRB- .
9766237	0	transferrin	56,67	TbpA	78,82	transferrin	TbpA	7018	7276	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Cooperation between the components of the meningococcal transferrin receptor , TbpA and TbpB , in the uptake of transferrin iron by the 37-kDa ferric-binding protein -LRB- FbpA -RRB- .
21056642	0	transferrin	13,24	Tf	26,28	transferrin	Tf	22041(Tax:10090)	22041(Tax:10090)	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of transferrin -LRB- Tf -RRB- conjugated liposomes via Staudinger ligation .
3662433	0	transferrin	16,27	Tf	29,31	transferrin	Tf	7018	7018	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of transferrin -LRB- Tf -RRB- subtypes in several Mongoloid populations of East Asia .
8675172	0	transferrin	52,63	Transferrin	0,11	transferrin	Transferrin	7018	7018	Gene	Gene	uptake|nmod|START_ENTITY uptake|amod|END_ENTITY	Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression .
7043719	0	transferrin	32,43	alpha-1-antitrypsin	9,28	transferrin	alpha-1-antitrypsin	7018	5265	Gene	Gene	Ratio|acl|START_ENTITY Ratio|nmod|END_ENTITY	Ratio of alpha-1-antitrypsin to transferrin in gingival fluid and in blood from patients with periodontal_disease .
6362658	0	transferrin	15,26	aminopeptidase	39,53	transferrin	aminopeptidase	7018	10404	Gene	Gene	Reliability|nmod|START_ENTITY END_ENTITY|nsubj|Reliability	Reliability of transferrin and leucine aminopeptidase phenotyping in wild meadow voles -LRB- Microtus pennsylvanicus -RRB- .
7726472	0	transferrin	84,95	beta-2	77,83	transferrin	beta-2	7018	10242	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- Perilymph fistula : diagnosis by detection of perilymph in the middle ear by beta-2 transferrin immunofixation -RSB- .
2064352	0	transferrin	28,39	c-myc	21,26	transferrin	c-myc	7018	4609	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Coordinate change of c-myc , transferrin receptor and H3 gene expression precedes induction of haemoglobin-producing cells of the leukaemia K562 cell line treated with cis-diamminedichloroplatinum _ -LRB- II -RRB- .
6265934	0	transferrin	82,93	cell_surface_glycoprotein	6,31	transferrin	cell surface glycoprotein	7018	9308	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Human cell_surface_glycoprotein related to cell proliferation is the receptor for transferrin .
12935417	0	transferrin	11,22	epidermal_growth_factor	97,120	transferrin	epidermal growth factor	7018	1950	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of transferrin on the growth and proliferation of porcine hepatocytes : a comparison with epidermal_growth_factor and nicotinamide .
3743768	0	transferrin	30,41	gastrin	11,18	transferrin	gastrin	7018	2520	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding of gastrin to gastric transferrin .
25737095	0	transferrin	73,84	granulocyte_macrophage_colony-stimulating_factor	24,72	transferrin	granulocyte macrophage colony-stimulating factor	7018	1437	Gene	Gene	proteins|compound|START_ENTITY proteins|amod|END_ENTITY	Engineering superactive granulocyte_macrophage_colony-stimulating_factor transferrin fusion proteins as orally-delivered candidate agents for treating neurodegenerative_disease .
7376785	0	transferrin	38,49	growth_hormone	51,65	transferrin	growth hormone	7018	2688	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|nsubj|relationship	A possible relationship between serum transferrin , growth_hormone secretion and height velocity in children .
12230555	0	transferrin	39,50	melanotransferrin	62,79	transferrin	melanotransferrin	7018	4241	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	The soluble form of the membrane-bound transferrin homologue , melanotransferrin , inefficiently donates iron to cells via nonspecific internalization and degradation of the protein .
12688510	0	transferrin	59,70	melanotransferrin	82,99	transferrin	melanotransferrin	7018	4241	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Iron uptake by melanoma cells from the soluble form of the transferrin homologue , melanotransferrin .
15716025	0	transferrin	39,50	melanotransferrin	62,79	transferrin	melanotransferrin	22041(Tax:10090)	4241	Gene	Gene	homologue|compound|START_ENTITY homologue|appos|END_ENTITY	Examination of the distribution of the transferrin homologue , melanotransferrin -LRB- tumour antigen p97 -RRB- , in mouse and human .
20213525	0	transferrin	50,61	prolactin	7,16	transferrin	prolactin	7018	5617	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Bovine prolactin promotes the expression of human transferrin in the milk of transgenic_mice .
1918133	0	transferrin	37,48	synaptophysin	18,31	transferrin	synaptophysin	7018	6855	Gene	Gene	receptors|compound|START_ENTITY END_ENTITY|nmod|receptors	Colocalization of synaptophysin with transferrin receptors : implications for synaptic vesicle biogenesis .
9245618	0	transferrin	117,128	tbpA	36,40	transferrin	tbpA	7018	7276	Gene	Gene	acquisition|amod|START_ENTITY receptors|nmod|acquisition topology|nmod|receptors analysis|dep|topology analysis|nmod|gene gene|compound|END_ENTITY	Sequence analysis of the structural tbpA gene : protein topology and variable regions within neisserial receptors for transferrin iron acquisition .
15957506	0	transferrin	16,27	transferrin	40,51	transferrin	transferrin	7018	7018	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Serum ferritin , transferrin and soluble transferrin receptor levels in multiple_sclerosis patients .
15957506	0	transferrin	40,51	transferrin	16,27	transferrin	transferrin	7018	7018	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Serum ferritin , transferrin and soluble transferrin receptor levels in multiple_sclerosis patients .
2332107	0	transferrin	104,115	transferrin	61,72	transferrin	transferrin	7018	7018	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of the structure and properties of normal human transferrin and a genetic variant of human transferrin .
2332107	0	transferrin	61,72	transferrin	104,115	transferrin	transferrin	7018	7018	Gene	Gene	comparison|nmod|START_ENTITY comparison|nmod|END_ENTITY	A comparison of the structure and properties of normal human transferrin and a genetic variant of human transferrin .
24264112	0	transferrin	16,27	transferrin	37,48	transferrin	transferrin	7018	7018	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of iron transferrin and zinc transferrin on ferritin synthesis by human lymphocytes .
24264112	0	transferrin	37,48	transferrin	16,27	transferrin	transferrin	7018	7018	Gene	Gene	START_ENTITY|nsubj|Effects Effects|nmod|END_ENTITY	Effects of iron transferrin and zinc transferrin on ferritin synthesis by human lymphocytes .
8424669	0	transferrin	31,42	transferrin	48,59	transferrin	transferrin	7018	7018	Gene	Gene	receptors|amod|START_ENTITY receptors|compound|END_ENTITY	Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells .
8424669	0	transferrin	48,59	transferrin	31,42	transferrin	transferrin	7018	7018	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Adriamycin conjugates of human transferrin bind transferrin receptors and kill K562 and HL60 cells .
10556042	0	transferrin	46,57	transferrin_receptor	77,97	transferrin	transferrin receptor	7018	7037	Gene	Gene	START_ENTITY|nmod|binding binding|nmod|END_ENTITY	The hemochromatosis protein HFE competes with transferrin for binding to the transferrin_receptor .
1510382	0	transferrin	98,109	transferrin_receptor	45,65	transferrin	transferrin receptor	7018	7037	Gene	Gene	modulating|nmod|START_ENTITY END_ENTITY|acl|modulating	Entry of iron into cells : a new role for the transferrin_receptor in modulating iron release from transferrin .
16164555	0	transferrin	92,103	transferrin_receptor	26,46	transferrin	transferrin receptor	477071(Tax:9615)	403703(Tax:9615)	Gene	Gene	uptake|nmod|START_ENTITY allow|dobj|uptake change|advcl|allow change|dobj|expression expression|compound|END_ENTITY	Trypanosomes change their transferrin_receptor expression to allow effective uptake of host transferrin .
16336271	0	transferrin	86,97	transferrin_receptor	111,131	transferrin	transferrin receptor	7018	7037	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the epitope of a monoclonal antibody that disrupts binding of human transferrin to the human transferrin_receptor .
19693784	0	transferrin	36,47	transferrin_receptor	79,99	transferrin	transferrin receptor	7018	7037	Gene	Gene	N-lobe|nmod|START_ENTITY loop|nmod|N-lobe critical|nsubj|loop critical|advcl|binding binding|nmod|END_ENTITY	A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin_receptor as revealed by mutagenesis , isothermal titration calorimetry , and epitope mapping .
1988034	0	transferrin	68,79	transferrin_receptor	19,39	transferrin	transferrin receptor	7018	7037	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A new role for the transferrin_receptor in the release of iron from transferrin .
21699959	0	transferrin	30,41	transferrin_receptor	55,75	transferrin	transferrin receptor	7018	7037	Gene	Gene	START_ENTITY|acl|bound bound|nmod|END_ENTITY	Kinetics of iron release from transferrin bound to the transferrin_receptor at endosomal pH. BACKGROUND : Human serum transferrin -LRB- hTF -RRB- is a bilobal glycoprotein that reversibly binds Fe -LRB- 3 + -RRB- and delivers it to cells by the process of receptor-mediated endocytosis .
21788477	0	transferrin	25,36	transferrin_receptor	48,68	transferrin	transferrin receptor	7018	7037	Gene	Gene	the|nmod|START_ENTITY primes|nsubj|the primes|dobj|END_ENTITY	How the binding of human transferrin primes the transferrin_receptor potentiating iron release at endosomal pH. Delivery of iron to cells requires binding of two iron-containing human transferrin -LRB- hTF -RRB- molecules to the specific homodimeric transferrin_receptor -LRB- TFR -RRB- on the cell surface .
2604716	0	transferrin	111,122	transferrin_receptor	45,65	transferrin	transferrin receptor	7018	7037	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the kinetics of cycling of the transferrin_receptor in the presence or absence of bound diferric transferrin .
2857182	0	transferrin	70,81	transferrin_receptor	25,45	transferrin	transferrin receptor	7018	7037	Gene	Gene	absence|nmod|START_ENTITY END_ENTITY|nmod|absence	Rapid endocytosis of the transferrin_receptor in the absence of bound transferrin .
3013902	0	transferrin	135,146	transferrin_receptor	73,93	transferrin	transferrin receptor	7018	7037	Gene	Gene	internalization|compound|START_ENTITY evidence|nmod|internalization Demonstration|dep|evidence Demonstration|nmod|specific specific|nmod|transferrin transferrin|nmod|END_ENTITY	Demonstration of the specific binding of bovine transferrin to the human transferrin_receptor in K562 cells : evidence for interspecies transferrin internalization .
3671994	0	transferrin	26,37	transferrin_receptor	39,59	transferrin	transferrin receptor	7018	7037	Gene	Gene	Analysis|nmod|START_ENTITY Analysis|appos|END_ENTITY	Analysis of the genes for transferrin , transferrin_receptor as well as H and L subunits of ferritin in idiopathic_hemochromatosis .
7530542	0	transferrin	67,78	transferrin_receptor	111,131	transferrin	transferrin receptor	7018	7037	Gene	Gene	antibody|compound|START_ENTITY antibody|acl:relcl|competes competes|nmod|END_ENTITY	Cloning , characterization , and modeling of a monoclonal anti-human transferrin antibody that competes with the transferrin_receptor .
8681959	0	transferrin	70,81	transferrin_receptor	33,53	transferrin	transferrin receptor	7018	7037	Gene	Gene	recycling|compound|START_ENTITY rates|nmod|recycling END_ENTITY|nmod|rates	Effects of overexpression of the transferrin_receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron .
8912898	2	transferrin	166,177	transferrin_receptor	203,223	transferrin	transferrin receptor	24825(Tax:10116)	64678(Tax:10116)	Gene	Gene	barrier|nmod|START_ENTITY transcytosis|nmod|barrier transcytosis|nmod|END_ENTITY	Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferrin and antibody against the transferrin_receptor .
15319290	0	transferrin	9,20	transferrin_receptor_2	31,53	transferrin	transferrin receptor 2	7018	7036	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|stability stability|amod|END_ENTITY	Diferric transferrin regulates transferrin_receptor_2 protein stability .
7770514	0	transferrin_receptor	12,32	CD71	34,38	transferrin receptor	CD71	7037	7037	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of transferrin_receptor -LRB- CD71 -RRB- in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic_acid -LRB- ALA -RRB- .
19339555	0	transferrin_receptor	31,51	ClC-4	22,27	transferrin receptor	ClC-4	22042(Tax:10090)	12727(Tax:10090)	Gene	Gene	function|compound|START_ENTITY END_ENTITY|nmod|function	An essential role for ClC-4 in transferrin_receptor function revealed in studies of fibroblasts derived from Clcn4-null mice .
14746681	0	transferrin_receptor	26,46	Erythropoietin	1,15	transferrin receptor	Erythropoietin	7037	2056	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	-LSB- Erythropoietin increases transferrin_receptor expression and the impact of erythropoietin on K562 leukemic cell cycle -RSB- .
11997026	0	transferrin_receptor	21,41	GABARAP	47,54	transferrin receptor	GABARAP	7037	11337	Gene	Gene	Association|nmod|START_ENTITY Association|nmod|END_ENTITY	Association of human transferrin_receptor with GABARAP .
10369785	0	transferrin_receptor	4,24	HFE	41,44	transferrin receptor	HFE	7037	3077	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The transferrin_receptor binding site on HFE , the class I MHC-related protein mutated in hereditary_hemochromatosis .
10638746	0	transferrin_receptor	80,100	HFE	61,64	transferrin receptor	HFE	7037	3077	Gene	Gene	complexed|nmod|START_ENTITY complexed|nsubj|structure structure|nmod|END_ENTITY	Crystal structure of the hereditary_haemochromatosis protein HFE complexed with transferrin_receptor .
9546397	0	transferrin_receptor	98,118	HFE	49,52	transferrin receptor	HFE	7037	3077	Gene	Gene	structure|nmod|START_ENTITY structure|nmod|END_ENTITY	Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin_receptor .
8948438	0	transferrin_receptor	38,58	Hsp-70	0,6	transferrin receptor	Hsp-70	7037	3308	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	Hsp-70 is closely associated with the transferrin_receptor in exosomes from maturing reticulocytes .
16680451	0	transferrin_receptor	47,67	Superoxide_dismutase_1	0,22	transferrin receptor	Superoxide dismutase 1	7037	6647	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Superoxide_dismutase_1 modulates expression of transferrin_receptor .
18261259	0	transferrin_receptor	40,60	erythropoietin	121,135	transferrin receptor	erythropoietin	7037	2056	Gene	Gene	START_ENTITY|nmod|reticulocytes reticulocytes|nmod|patients patients|acl|given given|dobj|END_ENTITY	A peculiar pattern of expression of the transferrin_receptor -LRB- CD71 -RRB- by reticulocytes in patients given recombinant human erythropoietin -LRB- rHuEPO -RRB- : a novel marker for abuse in sport ?
7936843	0	transferrin_receptor	37,57	erythropoietin	87,101	transferrin receptor	erythropoietin	7037	2056	Gene	Gene	concentration|nmod|START_ENTITY rise|nmod|concentration induced|nsubj|rise induced|nmod|END_ENTITY	Early rise in serum concentration of transferrin_receptor induced by recombinant human erythropoietin in very-low-birth-weight_infants .
8400253	0	transferrin_receptor	119,139	erythropoietin	50,64	transferrin receptor	erythropoietin	7037	2056	Gene	Gene	prediction|nmod|START_ENTITY prediction|nmod|END_ENTITY	Early prediction of response to recombinant human erythropoietin in patients with the anemia of renal_failure by serum transferrin_receptor and fibrinogen .
8921926	0	transferrin_receptor	12,32	erythropoietin	40,54	transferrin receptor	erythropoietin	7037	2056	Gene	Gene	Circulating|dobj|START_ENTITY Circulating|nmod|medication medication|compound|END_ENTITY	Circulating transferrin_receptor during erythropoietin medication of anemic patients with rheumatoid_arthritis .
9002972	0	transferrin_receptor	116,136	erythropoietin	42,56	transferrin receptor	erythropoietin	7037	2056	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression Regulation|dep|activation Regulation|nmod|metabolism metabolism|nmod|END_ENTITY	Regulation of cellular iron metabolism by erythropoietin : activation of iron-regulatory protein and upregulation of transferrin_receptor expression in erythroid cells .
22062951	0	transferrin_receptor	72,92	glyceraldehyde-3-phosphate_dehydrogenase	20,60	transferrin receptor	glyceraldehyde-3-phosphate dehydrogenase	7037	2597	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of glyceraldehyde-3-phosphate_dehydrogenase as a novel transferrin_receptor .
1701357	0	transferrin_receptor	17,37	granulocyte_colony-stimulating_factor	57,94	transferrin receptor	granulocyte colony-stimulating factor	7037	1440	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Up-regulation of transferrin_receptor gene expression by granulocyte_colony-stimulating_factor in human myeloid_leukemia cells .
3134021	0	transferrin_receptor	13,33	interferon_gamma	48,64	transferrin receptor	interferon gamma	7037	3458	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Reduction of transferrin_receptor expression by interferon_gamma in a human cell line sensitive to its antiproliferative effect .
16755932	0	transferrin_receptor	62,82	scFv	83,87	transferrin receptor	scFv	7037	652070	Gene	Gene	-RSB-|compound|START_ENTITY -RSB-|compound|END_ENTITY	-LSB- Expression , purification and activity analysis of anti-human transferrin_receptor scFv -RSB- .
10556042	0	transferrin_receptor	77,97	transferrin	46,57	transferrin receptor	transferrin	7037	7018	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|nmod|binding	The hemochromatosis protein HFE competes with transferrin for binding to the transferrin_receptor .
1510382	0	transferrin_receptor	45,65	transferrin	98,109	transferrin receptor	transferrin	7037	7018	Gene	Gene	START_ENTITY|acl|modulating modulating|nmod|END_ENTITY	Entry of iron into cells : a new role for the transferrin_receptor in modulating iron release from transferrin .
16164555	0	transferrin_receptor	26,46	transferrin	92,103	transferrin receptor	transferrin	403703(Tax:9615)	477071(Tax:9615)	Gene	Gene	expression|compound|START_ENTITY change|dobj|expression change|advcl|allow allow|dobj|uptake uptake|nmod|END_ENTITY	Trypanosomes change their transferrin_receptor expression to allow effective uptake of host transferrin .
16336271	0	transferrin_receptor	111,131	transferrin	86,97	transferrin receptor	transferrin	7037	7018	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the epitope of a monoclonal antibody that disrupts binding of human transferrin to the human transferrin_receptor .
19693784	0	transferrin_receptor	79,99	transferrin	36,47	transferrin receptor	transferrin	7037	7018	Gene	Gene	binding|nmod|START_ENTITY critical|advcl|binding critical|nsubj|loop loop|nmod|N-lobe N-lobe|nmod|END_ENTITY	A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin_receptor as revealed by mutagenesis , isothermal titration calorimetry , and epitope mapping .
1988034	0	transferrin_receptor	19,39	transferrin	68,79	transferrin receptor	transferrin	7037	7018	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A new role for the transferrin_receptor in the release of iron from transferrin .
21699959	0	transferrin_receptor	55,75	transferrin	30,41	transferrin receptor	transferrin	7037	7018	Gene	Gene	bound|nmod|START_ENTITY END_ENTITY|acl|bound	Kinetics of iron release from transferrin bound to the transferrin_receptor at endosomal pH. BACKGROUND : Human serum transferrin -LRB- hTF -RRB- is a bilobal glycoprotein that reversibly binds Fe -LRB- 3 + -RRB- and delivers it to cells by the process of receptor-mediated endocytosis .
21788477	0	transferrin_receptor	48,68	transferrin	25,36	transferrin receptor	transferrin	7037	7018	Gene	Gene	primes|dobj|START_ENTITY primes|nsubj|the the|nmod|END_ENTITY	How the binding of human transferrin primes the transferrin_receptor potentiating iron release at endosomal pH. Delivery of iron to cells requires binding of two iron-containing human transferrin -LRB- hTF -RRB- molecules to the specific homodimeric transferrin_receptor -LRB- TFR -RRB- on the cell surface .
2604716	0	transferrin_receptor	45,65	transferrin	111,122	transferrin receptor	transferrin	7037	7018	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of the kinetics of cycling of the transferrin_receptor in the presence or absence of bound diferric transferrin .
2857182	0	transferrin_receptor	25,45	transferrin	70,81	transferrin receptor	transferrin	7037	7018	Gene	Gene	START_ENTITY|nmod|absence absence|nmod|END_ENTITY	Rapid endocytosis of the transferrin_receptor in the absence of bound transferrin .
3013902	0	transferrin_receptor	73,93	transferrin	135,146	transferrin receptor	transferrin	7037	7018	Gene	Gene	transferrin|nmod|START_ENTITY specific|nmod|transferrin Demonstration|nmod|specific Demonstration|dep|evidence evidence|nmod|internalization internalization|compound|END_ENTITY	Demonstration of the specific binding of bovine transferrin to the human transferrin_receptor in K562 cells : evidence for interspecies transferrin internalization .
3671994	0	transferrin_receptor	39,59	transferrin	26,37	transferrin receptor	transferrin	7037	7018	Gene	Gene	Analysis|appos|START_ENTITY Analysis|nmod|END_ENTITY	Analysis of the genes for transferrin , transferrin_receptor as well as H and L subunits of ferritin in idiopathic_hemochromatosis .
7530542	0	transferrin_receptor	111,131	transferrin	67,78	transferrin receptor	transferrin	7037	7018	Gene	Gene	competes|nmod|START_ENTITY antibody|acl:relcl|competes antibody|compound|END_ENTITY	Cloning , characterization , and modeling of a monoclonal anti-human transferrin antibody that competes with the transferrin_receptor .
8681959	0	transferrin_receptor	33,53	transferrin	70,81	transferrin receptor	transferrin	7037	7018	Gene	Gene	START_ENTITY|nmod|rates rates|nmod|recycling recycling|compound|END_ENTITY	Effects of overexpression of the transferrin_receptor on the rates of transferrin recycling and uptake of non-transferrin-bound iron .
8912898	2	transferrin_receptor	203,223	transferrin	166,177	transferrin receptor	transferrin	64678(Tax:10116)	24825(Tax:10116)	Gene	Gene	transcytosis|nmod|START_ENTITY transcytosis|nmod|barrier barrier|nmod|END_ENTITY	Receptor-mediated transcytosis through the blood-brain barrier of blood-borne transferrin and antibody against the transferrin_receptor .
25635054	0	transferrin_receptor_2	38,60	CD81	0,4	transferrin receptor 2	CD81	7036	975	Gene	Gene	degradation|nmod|START_ENTITY promotes|dobj|degradation promotes|nsubj|END_ENTITY	CD81 promotes both the degradation of transferrin_receptor_2 -LRB- TfR2 -RRB- and the Tfr2-mediated maintenance of hepcidin expression .
18353247	0	transferrin_receptor_2	21,43	HFE	0,3	transferrin receptor 2	HFE	100752766	100762132	Gene	Gene	association|nmod|START_ENTITY association|compound|END_ENTITY	HFE association with transferrin_receptor_2 increases cellular uptake of transferrin-bound iron .
15319290	0	transferrin_receptor_2	31,53	transferrin	9,20	transferrin receptor 2	transferrin	7036	7018	Gene	Gene	stability|amod|START_ENTITY regulates|dobj|stability regulates|nsubj|END_ENTITY	Diferric transferrin regulates transferrin_receptor_2 protein stability .
11903063	0	transforming_acidic_coiled-coil_1	19,52	TACC1	54,59	transforming acidic coiled-coil 1	TACC1	6867	6867	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Interaction of the transforming_acidic_coiled-coil_1 -LRB- TACC1 -RRB- protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells .
15223781	0	transforming_growth_beta-induced_factor	25,64	TGIF	66,70	transforming growth beta-induced factor	TGIF	7050	7050	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence variants in the transforming_growth_beta-induced_factor -LRB- TGIF -RRB- gene are not associated with high_myopia .
18325497	0	transforming_growth_factor-alpha	52,84	Amphiregulin	0,12	transforming growth factor-alpha	Amphiregulin	7124	374	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Amphiregulin is much more abundantly expressed than transforming_growth_factor-alpha and epidermal_growth_factor in human follicular fluid obtained from patients undergoing in vitro fertilization-embryo transfer .
3262504	0	transforming_growth_factor-alpha	34,66	Interleukin-1	0,13	transforming growth factor-alpha	Interleukin-1	7124	3552	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Interleukin-1 in combination with transforming_growth_factor-alpha produces enhanced bone resorption in vitro .
11892999	0	transforming_growth_factor-alpha	23,55	Interleukin-6	0,13	transforming growth factor-alpha	Interleukin-6	7124	3569	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin-6 enhances transforming_growth_factor-alpha mRNA expression in macrophage-like human monocytoid -LRB- U-937-1 -RRB- cells .
10732760	0	transforming_growth_factor-alpha	29,61	TGF-alpha	63,72	transforming growth factor-alpha	TGF-alpha	7124	7039	Gene	Gene	perspectives|nmod|START_ENTITY perspectives|appos|END_ENTITY	Role and new perspectives of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in adenocarcinoma of the gastro-oesophageal junction .
15294092	0	transforming_growth_factor-alpha	11,43	TGF-alpha	45,54	transforming growth factor-alpha	TGF-alpha	21802(Tax:10090)	21802(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in vitro and in vivo on reovirus replication .
2064983	0	transforming_growth_factor-alpha	8,40	TGF-alpha	185,194	transforming growth factor-alpha	TGF-alpha	7124	24827(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|dep|studies studies|acl|using using|dobj|antibodies antibodies|compound|END_ENTITY	Role of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in basal and hormone-stimulated growth by estradiol , prolactin and progesterone in human and rat mammary tumor cells : studies using TGF-alpha and EGF_receptor antibodies .
9765263	0	transforming_growth_factor-alpha	32,64	TGF-alpha	66,75	transforming growth factor-alpha	TGF-alpha	7124	7039	Gene	Gene	minimization|nmod|START_ENTITY minimization|appos|END_ENTITY	Structure-based minimization of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- through NMR analysis of the receptor-bound ligand .
9797711	0	transforming_growth_factor-alpha	15,47	TGF-alpha	49,58	transforming growth factor-alpha	TGF-alpha	7124	7039	Gene	Gene	mRNA|compound|START_ENTITY mRNA|appos|END_ENTITY	High levels of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- mRNA may predict local relapses in early stage urinary bladder_cancer .
9850316	0	transforming_growth_factor-alpha	14,46	TGF-alpha	48,57	transforming growth factor-alpha	TGF-alpha	7124	7039	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of transforming_growth_factor-alpha -LRB- TGF-alpha -RRB- in cholesteatoma .
7829602	0	transforming_growth_factor-alpha	76,108	TGF_alpha	179,188	transforming growth factor-alpha	TGF alpha	7124	7039	Gene	Gene	acid|appos|START_ENTITY Expression|nmod|acid Expression|dep|role role|nmod|END_ENTITY	Expression of messenger ribonucleic acid for epidermal_growth_factor -LRB- EGF -RRB- , transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- , and EGF_receptor in human amnion cells : possible role of TGF_alpha in prostaglandin_E2 synthesis and cell proliferation .
8137635	0	transforming_growth_factor-alpha	14,46	TGF_alpha	48,57	transforming growth factor-alpha	TGF alpha	100009150(Tax:9986)	100009482(Tax:9986)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- on rabbit and primate lens epithelial cells in vitro .
8326464	0	transforming_growth_factor-alpha	29,61	TGF_alpha	63,72	transforming growth factor-alpha	TGF alpha	24827(Tax:10116)	24827(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|appos|END_ENTITY	Intrahepatic distribution of transforming_growth_factor-alpha -LRB- TGF_alpha -RRB- during liver_regeneration following carbon_tetrachloride-induced necrosis .
8358733	0	transforming_growth_factor-alpha	42,74	Transforming_growth_factor-beta_1	0,33	transforming growth factor-alpha	Transforming growth factor-beta 1	7124	7040	Gene	Gene	activity|amod|START_ENTITY induces|dobj|activity induces|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 induces transforming_growth_factor-alpha promoter activity and transforming_growth_factor-alpha secretion in the human colon_adenocarcinoma cell line FET .
2168868	0	transforming_growth_factor-alpha	98,130	epidermal_growth_factor	67,90	transforming growth factor-alpha	epidermal growth factor	7124	1950	Gene	Gene	START_ENTITY|nsubj|Induction Induction|nmod|END_ENTITY	Induction of growth factor-receptor and metalloproteinase genes by epidermal_growth_factor and/or transforming_growth_factor-alpha in human gastric_carcinoma cell line MKN-28 .
8625491	0	transforming_growth_factor-alpha	18,50	epidermal_growth_factor	97,120	transforming growth factor-alpha	epidermal growth factor	7124	1950	Gene	Gene	Overexpression|nmod|START_ENTITY END_ENTITY|nsubj|Overexpression	Overexpression of transforming_growth_factor-alpha and epidermal_growth_factor_receptor , but not epidermal_growth_factor , in exocrine pancreatic_tumours in hamsters .
12202486	0	transforming_growth_factor-alpha	131,163	epidermal_growth_factor_receptor	23,55	transforming growth factor-alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	release|nmod|START_ENTITY requires|dobj|release requires|nsubj|Transactivation Transactivation|nmod|END_ENTITY	Transactivation of the epidermal_growth_factor_receptor in colonic epithelial cells by carbachol requires extracellular release of transforming_growth_factor-alpha .
12944410	0	transforming_growth_factor-alpha	39,71	epidermal_growth_factor_receptor	72,104	transforming growth factor-alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	activates|dobj|START_ENTITY activates|dep|growth growth|dep|END_ENTITY	Hypoxia inducible factor activates the transforming_growth_factor-alpha / epidermal_growth_factor_receptor growth stimulatory pathway in VHL -LRB- - / - -RRB- renal_cell_carcinoma cells .
8702723	0	transforming_growth_factor-alpha	45,77	epidermal_growth_factor_receptor	4,36	transforming growth factor-alpha	epidermal growth factor receptor	21802(Tax:10090)	13649(Tax:10090)	Gene	Gene	factor|amod|START_ENTITY couples|dobj|factor couples|nsubj|END_ENTITY	The epidermal_growth_factor_receptor couples transforming_growth_factor-alpha , heparin-binding epidermal growth factor-like factor , and amphiregulin to Neu , ErbB-3 , and ErbB-4 .
12099554	0	transforming_growth_factor-alpha	13,45	matrix_metalloproteinase-9	91,117	transforming growth factor-alpha	matrix metalloproteinase-9	21802(Tax:10090)	17395(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Influence of transforming_growth_factor-alpha on expression of matrix_metalloproteinase-2 , matrix_metalloproteinase-9 , and epidermal_growth_factor_receptor gene in the mouse blastocysts .
17166098	0	transforming_growth_factor-alpha	15,47	proliferating_cell_nuclear_antigen	90,124	transforming growth factor-alpha	proliferating cell nuclear antigen	7124	5111	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of transforming_growth_factor-alpha and epidermal_growth_factor_receptor with proliferating_cell_nuclear_antigen in human burn wounds .
25234355	0	transforming_growth_factor-b	102,130	ALK5	155,159	transforming growth factor-b	ALK5	7040	7046	Gene	Gene	kinase|amod|START_ENTITY kinase|appos|END_ENTITY	Design , synthesis and evaluation of small molecule imidazo -LSB- 2,1-b -RSB- -LSB- 1,3,4 -RSB- thiadiazoles as inhibitors of transforming_growth_factor-b type-I receptor kinase -LRB- ALK5 -RRB- .
26251265	0	transforming_growth_factor-b	35,63	CD73	111,115	transforming growth factor-b	CD73	7040	4907	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	1a,25-dihydroxyvitamin _ D3 acts via transforming_growth_factor-b to up-regulate expression of immunosuppressive CD73 on human CD4 -LRB- + -RRB- Foxp3 -LRB- - -RRB- T cells .
24509415	0	transforming_growth_factor-b	16,44	GATA-2	0,6	transforming growth factor-b	GATA-2	7040	2624	Gene	Gene	inhibits|xcomp|START_ENTITY inhibits|nsubj|END_ENTITY	GATA-2 inhibits transforming_growth_factor-b signaling pathway through interaction with Smad4 .
22391036	0	transforming_growth_factor-b	92,120	JunB	0,4	transforming growth factor-b	JunB	7040	3726	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming_growth_factor-b .
25858550	0	transforming_growth_factor-b	7,35	LTBP-1	54,60	transforming growth factor-b	LTBP-1	7040	4052	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Latent transforming_growth_factor-b binding proteins -LRB- LTBP-1 and LTBP-2 -RRB- and gingiva keratinization .
25858550	0	transforming_growth_factor-b	7,35	LTBP-1	54,60	transforming growth factor-b	LTBP-1	7040	4052	Gene	Gene	proteins|amod|START_ENTITY proteins|dep|END_ENTITY	Latent transforming_growth_factor-b binding proteins -LRB- LTBP-1 and LTBP-2 -RRB- and gingiva keratinization .
23904368	0	transforming_growth_factor-b	46,74	MG132	33,38	transforming growth factor-b	MG132	7040	875581(Tax:243273)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of the protease inhibitor MG132 on the transforming_growth_factor-b / Smad signaling pathway in HSC-T6 cells .
25082541	0	transforming_growth_factor-b	84,112	SHON	0,4	transforming growth factor-b	SHON	7040	3092	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	SHON , a novel secreted protein , regulates epithelial-mesenchymal transition through transforming_growth_factor-b signaling in human breast_cancer cells .
22781750	0	transforming_growth_factor-b	54,82	SMAD3	32,37	transforming growth factor-b	SMAD3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	pathway|amod|START_ENTITY function|nmod|pathway function|compound|END_ENTITY	Protein phosphatase 5 modulates SMAD3 function in the transforming_growth_factor-b pathway .
24550394	0	transforming_growth_factor-b	96,124	SMAD3	153,158	transforming growth factor-b	SMAD3	7040	4088	Gene	Gene	leads|nmod|START_ENTITY pathway|acl:relcl|leads pathway|acl|signaling signaling|advcl|promoting promoting|dobj|activation activation|compound|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming_growth_factor-b -LRB- TGF-b -RRB- signaling promoting SMAD3 activation and fibrosis via Gremlin protein .
22778267	0	transforming_growth_factor-b	11,39	Smad3	48,53	transforming growth factor-b	Smad3	21803(Tax:10090)	17127(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
24811173	0	transforming_growth_factor-b	24,52	Smad3	61,66	transforming growth factor-b	Smad3	7040	4088	Gene	Gene	START_ENTITY|dep|protein protein|amod|END_ENTITY	Caerulomycin_A enhances transforming_growth_factor-b -LRB- TGF-b -RRB- - Smad3 protein signaling by suppressing interferon-y -LRB- IFN-y -RRB- - signal transducer and activator of transcription 1 -LRB- STAT1 -RRB- protein signaling to expand regulatory T cells -LRB- Tregs -RRB- .
20458184	0	transforming_growth_factor-b	27,55	TGF-b	57,62	transforming growth factor-b	TGF-b	7040	7040	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Regulation of autophagy by transforming_growth_factor-b -LRB- TGF-b -RRB- signaling .
22707720	0	transforming_growth_factor-b	46,74	TGF-b	76,81	transforming growth factor-b	TGF-b	7040	7040	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Coated pit-mediated endocytosis of the type I transforming_growth_factor-b -LRB- TGF-b -RRB- receptor depends on a di-leucine family signal and is not required for signaling .
22778267	0	transforming_growth_factor-b	11,39	TGF-b	41,46	transforming growth factor-b	TGF-b	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Zyxin is a transforming_growth_factor-b -LRB- TGF-b -RRB- / Smad3 target gene that regulates lung_cancer cell motility via integrin a5b1 .
25714613	0	transforming_growth_factor-b	35,63	TGF-b	65,70	transforming growth factor-b	TGF-b	7040	7040	Gene	Gene	function|nmod|START_ENTITY function|appos|END_ENTITY	The immune suppressive function of transforming_growth_factor-b -LRB- TGF-b -RRB- in human diseases .
23250756	0	transforming_growth_factor-b	95,123	TGFb	125,129	transforming growth factor-b	TGFb	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	The transcription factor paired-related_homeobox_1 -LRB- Prrx1 -RRB- inhibits adipogenesis by activating transforming_growth_factor-b -LRB- TGFb -RRB- signaling .
26081960	0	transforming_growth_factor-b1	52,81	E-cadherin	19,29	transforming growth factor-b1	E-cadherin	7040	999	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The expression of E-cadherin , vimentin , b-catenin , transforming_growth_factor-b1 in oral_squamous_cell_carcinomas -RSB- .
21109948	0	transforming_growth_factor-b1	80,109	L1CAM	126,131	transforming growth factor-b1	L1CAM	7040	3897	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
21109948	0	transforming_growth_factor-b1	80,109	Slug	36,40	transforming growth factor-b1	Slug	7040	6591	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|Binding Binding|acl|END_ENTITY	Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming_growth_factor-b1 -LRB- TGF-b -RRB- - induced L1CAM expression in human pancreatic_ductal_adenocarcinoma cells .
22942286	0	transforming_growth_factor-b1	137,166	Smad_anchor_for_receptor_activation	69,104	transforming growth factor-b1	Smad anchor for receptor activation	7040	9372	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Phosphatidylinositol_3-kinase and Rab5 GTPase inversely regulate the Smad_anchor_for_receptor_activation -LRB- SARA -RRB- protein independently of transforming_growth_factor-b1 .
22465044	0	transforming_growth_factor-b1	29,58	TGF-b1	60,66	transforming growth factor-b1	TGF-b1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The T29C polymorphism of the transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- gene is associated with genetic susceptibility to acute_coronary_syndrome in Mexican patients .
25449332	0	transforming_growth_factor-b1	41,70	TGF-b1	72,78	transforming growth factor-b1	TGF-b1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The T29C -LRB- rs1800470 -RRB- polymorphism of the transforming_growth_factor-b1 -LRB- TGF-b1 -RRB- gene is associated with restenosis after coronary stenting in Mexican patients .
26048435	0	transforming_growth_factor-b1	28,57	TGFB1	59,64	transforming growth factor-b1	TGFB1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	c. 29C > T polymorphism in the transforming_growth_factor-b1 -LRB- TGFB1 -RRB- gene correlates with increased risk of urinary bladder_cancer .
26081960	0	transforming_growth_factor-b1	52,81	b-catenin	41,50	transforming growth factor-b1	b-catenin	7040	1499	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|amod|END_ENTITY	-LSB- The expression of E-cadherin , vimentin , b-catenin , transforming_growth_factor-b1 in oral_squamous_cell_carcinomas -RSB- .
24582746	0	transforming_growth_factor-b1	60,89	homeobox_B9	14,25	transforming growth factor-b1	homeobox B9	7040	3219	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Overexpressed homeobox_B9 regulates oncogenic activities by transforming_growth_factor-b1 in gliomas .
26097586	0	transforming_growth_factor-b1	18,47	miR-144	0,7	transforming growth factor-b1	miR-144	7040	406936	Gene	Gene	activation|amod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	miR-144 regulates transforming_growth_factor-b1 iduced hepatic stellate cell activation in human fibrotic liver .
25197353	0	transforming_growth_factor-b2	11,40	myocilin	44,52	transforming growth factor-b2	myocilin	7042	4653	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Effects of transforming_growth_factor-b2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells .
12242728	0	transforming_growth_factor-beta	51,82	Bcl-2	0,5	transforming growth factor-beta	Bcl-2	7040	596	Gene	Gene	effect|nmod|START_ENTITY antagonizes|dobj|effect antagonizes|nsubj|END_ENTITY	Bcl-2 antagonizes the combined apoptotic effect of transforming_growth_factor-beta and dihydrotestosterone in prostate_cancer cells .
2170518	0	transforming_growth_factor-beta	70,101	C-reactive_protein	37,55	transforming growth factor-beta	C-reactive protein	7040	1401	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|amod|END_ENTITY	Regulation of cytokine-induced human C-reactive_protein production by transforming_growth_factor-beta .
25878769	0	transforming_growth_factor-beta	63,94	C/EBPb	109,115	transforming growth factor-beta	C/EBPb	7040	1051	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Retinoic_acid promotes myogenesis in myoblasts by antagonizing transforming_growth_factor-beta signaling via C/EBPb .
25878769	0	transforming_growth_factor-beta	63,94	C/EBPb	109,115	transforming growth factor-beta	C/EBPb	7040	1051	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Retinoic_acid promotes myogenesis in myoblasts by antagonizing transforming_growth_factor-beta signaling via C/EBPb .
16416233	0	transforming_growth_factor-beta	42,73	CD4	135,138	transforming growth factor-beta	CD4	7040	920	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Flow cytometric analysis of expression of transforming_growth_factor-beta and glucocorticoid-induced_tumor_necrosis_factor_receptor on CD4 -LRB- + -RRB- CD25 -LRB- + -RRB- T cells of patients with inflammatory_bowel_disease .
15298857	0	transforming_growth_factor-beta	60,91	Connective_tissue_growth_factor	0,31	transforming growth factor-beta	Connective tissue growth factor	7040	1490	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Connective_tissue_growth_factor expression and induction by transforming_growth_factor-beta is abrogated by simvastatin via a Rho signaling mechanism .
11290559	0	transforming_growth_factor-beta	84,115	Cyclooxygenase-2	0,16	transforming growth factor-beta	Cyclooxygenase-2	7040	5743	Gene	Gene	response|nmod|START_ENTITY loss|nmod|response results|nmod|loss results|amod|END_ENTITY	Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming_growth_factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary_fibrosis in mice .
2139455	0	transforming_growth_factor-beta	59,90	Fc_gamma_RIII	23,36	transforming growth factor-beta	Fc gamma RIII	7040	2214	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Selective induction of Fc_gamma_RIII on human monocytes by transforming_growth_factor-beta .
12021267	1	transforming_growth_factor-beta	122,153	Fibulin-5	98,107	transforming growth factor-beta	Fibulin-5	7040	10516	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Fibulin-5 is induced by transforming_growth_factor-beta and affects protein kinase cascades .
10518526	0	transforming_growth_factor-beta	33,64	Glucocorticoid_receptor	0,23	transforming growth factor-beta	Glucocorticoid receptor	7040	2908	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Glucocorticoid_receptor inhibits transforming_growth_factor-beta signaling by directly targeting the transcriptional activation function of Smad3 .
1653804	0	transforming_growth_factor-beta	65,96	IL-4	0,4	transforming growth factor-beta	IL-4	7040	3565	Gene	Gene	antagonizes|nmod|START_ENTITY antagonizes|nsubj|END_ENTITY	IL-4 antagonizes induction of Fc_gamma_RIII -LRB- CD16 -RRB- expression by transforming_growth_factor-beta on human monocytes .
9344494	0	transforming_growth_factor-beta	69,100	IL-8	40,44	transforming growth factor-beta	IL-8	7040	3576	Gene	Gene	role|nmod|START_ENTITY production|dep|role production|compound|END_ENTITY	Cocaine inhibits human endothelial cell IL-8 production : the role of transforming_growth_factor-beta .
1880476	0	transforming_growth_factor-beta	115,146	Insulin-like_growth_factor-I	0,28	transforming growth factor-beta	Insulin-like growth factor-I	7040	3479	Gene	Gene	regulation|nmod|START_ENTITY production|dep|regulation production|amod|END_ENTITY	Insulin-like_growth_factor-I production and action in porcine thyroid follicular cells in monolayer : regulation by transforming_growth_factor-beta .
2124978	0	transforming_growth_factor-beta	93,124	Interferon-gamma	0,16	transforming growth factor-beta	Interferon-gamma	7040	3458	Gene	Gene	reverses|nmod|START_ENTITY reverses|nsubj|END_ENTITY	Interferon-gamma reverses the stimulation of collagen but not fibronectin gene expression by transforming_growth_factor-beta in normal human fibroblasts .
8194369	0	transforming_growth_factor-beta	39,70	Interferon-gamma	0,16	transforming growth factor-beta	Interferon-gamma	7040	3458	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interferon-gamma induces high-affinity transforming_growth_factor-beta receptor expression on human corneal fibroblasts .
11145962	1	transforming_growth_factor-beta	126,157	MMP-13	102,108	transforming growth factor-beta	MMP-13	7040	4322	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	a role for matrix vesicle-associated MMP-13 in activation of transforming_growth_factor-beta .
1694856	0	transforming_growth_factor-beta	82,113	PDGF-A	8,14	transforming growth factor-beta	PDGF-A	7040	5154	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming_growth_factor-beta .
16788944	0	transforming_growth_factor-beta	27,58	Smad2	18,23	transforming growth factor-beta	Smad2	7040	4087	Gene	Gene	signaling|amod|START_ENTITY END_ENTITY|nmod|signaling	Lack of activated Smad2 in transforming_growth_factor-beta signaling is an unfavorable prognostic factor in patients with esophageal_squamous_cell_carcinoma .
10518526	0	transforming_growth_factor-beta	33,64	Smad3	140,145	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	START_ENTITY|acl|signaling signaling|advcl|targeting targeting|dobj|function function|nmod|END_ENTITY	Glucocorticoid_receptor inhibits transforming_growth_factor-beta signaling by directly targeting the transcriptional activation function of Smad3 .
10531318	0	transforming_growth_factor-beta	15,46	Smad3	0,5	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Smad3 inhibits transforming_growth_factor-beta and activin signaling by competing with Smad4 for FAST-2 binding .
11248024	0	transforming_growth_factor-beta	5,36	Smad3	85,90	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	coregulator|nmod|START_ENTITY coregulator|nsubj|identification identification|nmod|END_ENTITY	From transforming_growth_factor-beta signaling to androgen action : identification of Smad3 as an androgen_receptor coregulator in prostate_cancer cells .
11555647	0	transforming_growth_factor-beta	19,50	Smad3	91,96	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	Cross-talk|nmod|START_ENTITY Cross-talk|acl|signaling signaling|nmod|END_ENTITY	Cross-talk between transforming_growth_factor-beta and estrogen_receptor signaling through Smad3 .
12876289	0	transforming_growth_factor-beta	67,98	Smad3	179,184	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	responses|nmod|START_ENTITY inhibits|dobj|responses inhibits|nmod|suppression suppression|nmod|activation activation|nmod|END_ENTITY	Insulin-like_growth_factor-I inhibits transcriptional responses of transforming_growth_factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2 .
14980084	0	transforming_growth_factor-beta	107,138	Smad3	62,67	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	signaling|amod|START_ENTITY Contribution|nmod|signaling Contribution|nmod|degradation degradation|nmod|END_ENTITY	Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming_growth_factor-beta signaling .
15001984	0	transforming_growth_factor-beta	27,58	Smad3	96,101	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	upregulation|nmod|START_ENTITY involves|nsubj|upregulation involves|dobj|END_ENTITY	Tenascin-C upregulation by transforming_growth_factor-beta in human dermal fibroblasts involves Smad3 , Sp1 , and Ets1 .
19458083	0	transforming_growth_factor-beta	31,62	Smad3	112,117	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	control|nmod|START_ENTITY synthase|nsubj|control synthase|dobj|phosphorylation phosphorylation|compound|END_ENTITY	A negative feedback control of transforming_growth_factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204 .
20037158	0	transforming_growth_factor-beta	88,119	Smad3	0,5	transforming growth factor-beta	Smad3	7040	4088	Gene	Gene	responses|amod|START_ENTITY dictate|dobj|responses modulated|xcomp|dictate modulated|nsubjpass|levels levels|amod|END_ENTITY	Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming_growth_factor-beta responses .
15592526	0	transforming_growth_factor-beta	118,149	Smad4	0,5	transforming growth factor-beta	Smad4	7040	4089	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Smad4 silencing in pancreatic_cancer cell lines using stable RNA interference and gene expression profiles induced by transforming_growth_factor-beta .
12547835	0	transforming_growth_factor-beta	46,77	Smads_2_and_3	0,13	transforming growth factor-beta	Smads 2 and 3	7040	4087;4088	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Smads_2_and_3 are differentially activated by transforming_growth_factor-beta -LRB- TGF-beta -RRB- in quiescent and activated hepatic stellate cells .
10193412	0	transforming_growth_factor-beta	22,53	TGF-beta	55,63	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Inhibitory effects of transforming_growth_factor-beta -LRB- TGF-beta -RRB- on certain functions of intraepithelial lymphocytes .
10793000	0	transforming_growth_factor-beta	8,39	TGF-beta	41,49	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Loss of transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptor type I mediates TGF-beta resistance in human_papillomavirus_type_16-transformed human keratinocytes at late stages of in vitro progression .
12675860	0	transforming_growth_factor-beta	15,46	TGF-beta	48,56	Transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of transforming_growth_factor-beta -LRB- TGF-beta -RRB- T869C -LRB- Leu_10Pro -RRB- gene polymorphisms with type 2 diabetic_nephropathy in Chinese .
1310325	0	transforming_growth_factor-beta	49,80	TGF-beta	82,90	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Subtypes of betaglycan and of type I and type II transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors with different affinities for TGF-beta_1 and TGF-beta_2 are exhibited by human placental trophoblast cells .
1333844	0	transforming_growth_factor-beta	20,51	TGF-beta	53,61	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Characterization of transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors on BeWo choriocarcinoma cells including the identification of a novel 38-kDa TGF-beta binding glycoprotein .
1433985	0	transforming_growth_factor-beta	65,96	TGF-beta	98,106	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Function , molecular structure and gene expression regulation of transforming_growth_factor-beta -LRB- TGF-beta -RRB- -RSB- .
15808954	0	transforming_growth_factor-beta	28,59	TGF-beta	61,69	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	Functions|nmod|START_ENTITY Functions|appos|END_ENTITY	Functions and regulation of transforming_growth_factor-beta -LRB- TGF-beta -RRB- in the prostate .
16162149	0	transforming_growth_factor-beta	21,52	TGF-beta	59,67	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the transforming_growth_factor-beta gene -LRB- TGF-beta -RRB- and the risk of advanced alcoholic_liver_disease .
1906362	0	transforming_growth_factor-beta	37,68	TGF-beta	70,78	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	-LSB- Immunohistochemical localization of transforming_growth_factor-beta -LRB- TGF-beta -RRB- in smooth muscle tissue -RSB- .
7697928	0	transforming_growth_factor-beta	23,54	TGF-beta	56,64	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	production|nmod|START_ENTITY production|appos|END_ENTITY	Enhanced production of transforming_growth_factor-beta -LRB- TGF-beta -RRB- during autologous mixed lymphocyte reaction of systemic sclerosis patients .
7721333	0	transforming_growth_factor-beta	13,44	TGF-beta	46,54	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of transforming_growth_factor-beta -LRB- TGF-beta -RRB- on the immunoglobulin production by EBV-infected B cell cultures .
8050825	0	transforming_growth_factor-beta	14,45	TGF-beta	47,55	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression of transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors , TGF-beta_1 and TGF-beta_2 production and autocrine growth control in osteosarcoma cells .
8149667	0	transforming_growth_factor-beta	59,90	TGF-beta	92,100	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Increased levels of interferon-gamma -LRB- IFN-gamma -RRB- , IL-4 and transforming_growth_factor-beta -LRB- TGF-beta -RRB- mRNA expressing blood mononuclear cells in human HIV_infection .
8576191	0	transforming_growth_factor-beta	15,46	TGF-beta	48,56	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Requirement of transforming_growth_factor-beta -LRB- TGF-beta -RRB- type II receptor for TGF-beta-induced proliferation and growth inhibition .
9570266	0	transforming_growth_factor-beta	8,39	TGF-beta	41,49	transforming growth factor-beta	TGF-beta	7040	7040	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	Ovarian transforming_growth_factor-beta -LRB- TGF-beta -RRB- receptors : in-vitro effects of follicle stimulating hormone , epidermal growth factor and TGF-beta on receptor expression in human preantral follicles .
16891311	0	transforming_growth_factor-beta	45,76	TGF_beta	78,86	transforming growth factor-beta	TGF beta	7040	7040	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Requirement of Smad3 and CREB-1 in mediating transforming_growth_factor-beta -LRB- TGF_beta -RRB- induction of TGF_beta 3 secretion .
21321980	0	transforming_growth_factor-beta	12,43	TGFb	45,49	transforming growth factor-beta	TGFb	7040	7040	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Blockade of transforming_growth_factor-beta -LRB- TGFb -RRB- signaling inhibits osteoblastic tumorigenesis by a novel human prostate_cancer cell line .
19088080	0	transforming_growth_factor-beta	17,48	TGFbeta	50,57	transforming growth factor-beta	TGFbeta	7040	7040	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Silencing of the transforming_growth_factor-beta -LRB- TGFbeta -RRB- receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling .
19787707	0	transforming_growth_factor-beta	12,43	TGFbeta	45,52	transforming growth factor-beta	TGFbeta	7040	7040	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	The tale of transforming_growth_factor-beta -LRB- TGFbeta -RRB- signaling : a soign enigma .
17203972	0	transforming_growth_factor-beta	15,46	TbetaRI	64,71	transforming growth factor-beta	TbetaRI	7040	7046	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Interactome of transforming_growth_factor-beta type I receptor -LRB- TbetaRI -RRB- : inhibition of TGFbeta signaling by Epac1 .
15001984	0	transforming_growth_factor-beta	27,58	Tenascin-C	0,10	transforming growth factor-beta	Tenascin-C	7040	3371	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Tenascin-C upregulation by transforming_growth_factor-beta in human dermal fibroblasts involves Smad3 , Sp1 , and Ets1 .
9075121	0	transforming_growth_factor-beta	34,65	Thrombin	0,8	transforming growth factor-beta	Thrombin	7040	2147	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Thrombin stimulates production of transforming_growth_factor-beta by cultured human mesangial cells .
15221015	0	transforming_growth_factor-beta	23,54	WW_domain-containing_protein_1	79,109	transforming growth factor-beta	WW domain-containing protein 1	7040	11059	Gene	Gene	regulation|nmod|START_ENTITY regulation|acl|signaling signaling|nmod|END_ENTITY	Negative regulation of transforming_growth_factor-beta -LRB- TGF-beta -RRB- signaling by WW_domain-containing_protein_1 -LRB- WWP1 -RRB- .
17657819	0	transforming_growth_factor-beta	14,45	activin_receptor-like_kinase_5	46,76	transforming growth factor-beta	activin receptor-like kinase 5	7040	7046	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Profibrogenic transforming_growth_factor-beta / activin_receptor-like_kinase_5 signaling via connective_tissue_growth_factor expression in hepatocytes .
9582381	0	transforming_growth_factor-beta	37,68	alpha2-macroglobulin	78,98	transforming growth factor-beta	alpha2-macroglobulin	7040	2	Gene	Gene	Localization|nmod|START_ENTITY Localization|nmod|END_ENTITY	Localization of the binding site for transforming_growth_factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region .
2473082	0	transforming_growth_factor-beta	91,122	alpha_2-macroglobulin	123,144	transforming growth factor-beta	alpha 2-macroglobulin	7040	2	Gene	Gene	complex|amod|START_ENTITY complex|amod|END_ENTITY	Transforming_growth_factor-beta activity is potentiated by heparin via dissociation of the transforming_growth_factor-beta / alpha_2-macroglobulin inactive complex .
12140283	0	transforming_growth_factor-beta	63,94	biglycan	35,43	transforming growth factor-beta	biglycan	7040	633	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Smad4/DPC4-dependent regulation of biglycan gene expression by transforming_growth_factor-beta in pancreatic_tumor cells .
12538652	0	transforming_growth_factor-beta	42,73	biglycan	14,22	transforming growth factor-beta	biglycan	7040	633	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of biglycan gene expression by transforming_growth_factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling .
16051607	0	transforming_growth_factor-beta	70,101	biglycan	42,50	transforming growth factor-beta	biglycan	7040	633	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming_growth_factor-beta .
17900349	0	transforming_growth_factor-beta	103,134	bone_morphogenic_protein	135,159	transforming growth factor-beta	bone morphogenic protein	7040	649	Gene	Gene	signalling|amod|START_ENTITY signalling|compound|END_ENTITY	Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling , WNT and transforming_growth_factor-beta / bone_morphogenic_protein signalling .
14667198	0	transforming_growth_factor-beta	61,92	c-kit	15,20	transforming growth factor-beta	c-kit	7040	3815	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Correlation of c-kit expression and cell cycle regulation by transforming_growth_factor-beta in CD34 + CD38 - human bone marrow cells .
7544639	0	transforming_growth_factor-beta	66,97	c-kit	123,128	transforming growth factor-beta	c-kit	7040	3815	Gene	Gene	downmodulates|nsubj|START_ENTITY downmodulates|dobj|cells cells|compound|END_ENTITY	Early CD34high cells can be separated into KIThigh cells in which transforming_growth_factor-beta -LRB- TGF-beta -RRB- downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit .
7544639	0	transforming_growth_factor-beta	66,97	c-kit	181,186	transforming growth factor-beta	c-kit	7040	3815	Gene	Gene	downmodulates|nsubj|START_ENTITY downmodulates|dobj|cells cells|acl:relcl|upmodulates upmodulates|xcomp|END_ENTITY	Early CD34high cells can be separated into KIThigh cells in which transforming_growth_factor-beta -LRB- TGF-beta -RRB- downmodulates c-kit and KITlow cells in which anti-TGF-beta upmodulates c-kit .
2334536	0	transforming_growth_factor-beta	118,149	carcinoembryonic_antigen	13,37	transforming growth factor-beta	carcinoembryonic antigen	7040	1084	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of carcinoembryonic_antigen and its crossreactive gene products in human colonic_adenomas and carcinomas by transforming_growth_factor-beta .
3289738	0	transforming_growth_factor-beta	164,195	carcinoembryonic_antigen	13,37	transforming growth factor-beta	carcinoembryonic antigen	7040	1084	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|secretion secretion|compound|END_ENTITY	Induction of carcinoembryonic_antigen secretion and modulation of protein secretion/expression and fibronectin/laminin expression in human colon_carcinoma cells by transforming_growth_factor-beta .
16196369	0	transforming_growth_factor-beta	62,93	cathepsin_D	10,21	transforming growth factor-beta	cathepsin D	7040	1509	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of cathepsin_D and prostate_specific_antigen on latent transforming_growth_factor-beta in breast_cancer cell lines .
10809757	0	transforming_growth_factor-beta	91,122	connective_tissue_growth_factor	56,87	transforming growth factor-beta	connective tissue growth factor	7040	1490	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|dobj|induction induction|nmod|END_ENTITY	Tumor_necrosis factor alpha suppresses the induction of connective_tissue_growth_factor by transforming_growth_factor-beta in normal and scleroderma fibroblasts .
11673871	0	transforming_growth_factor-beta	30,61	connective_tissue_growth_factor	77,108	transforming growth factor-beta	connective tissue growth factor	7040	1490	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|expression expression|compound|END_ENTITY	Signaling events required for transforming_growth_factor-beta stimulation of connective_tissue_growth_factor expression by cultured human lung fibroblasts .
16217483	0	transforming_growth_factor-beta	94,125	connective_tissue_growth_factor	45,76	transforming growth factor-beta	connective tissue growth factor	7040	1490	Gene	Gene	stimulation|amod|START_ENTITY increased|nmod|stimulation increased|dobj|expression expression|compound|END_ENTITY	Hypertrophic_scar fibroblasts have increased connective_tissue_growth_factor expression after transforming_growth_factor-beta stimulation .
17657819	0	transforming_growth_factor-beta	14,45	connective_tissue_growth_factor	91,122	transforming growth factor-beta	connective tissue growth factor	7040	1490	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nmod|expression expression|compound|END_ENTITY	Profibrogenic transforming_growth_factor-beta / activin_receptor-like_kinase_5 signaling via connective_tissue_growth_factor expression in hepatocytes .
16489006	0	transforming_growth_factor-beta	59,90	cyclooxygenase-2	15,31	transforming growth factor-beta	cyclooxygenase-2	7040	5743	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of cyclooxygenase-2 expression by bone-derived transforming_growth_factor-beta enhances bone metastases in breast_cancer .
17959708	0	transforming_growth_factor-beta	33,64	cyclooxygenase-2	103,119	transforming growth factor-beta	cyclooxygenase-2	7040	5743	Gene	Gene	administration|nmod|START_ENTITY evokes|nsubj|administration evokes|nmod|induction induction|nmod|cells cells|amod|END_ENTITY	Intracisternal administration of transforming_growth_factor-beta evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells .
17209135	0	transforming_growth_factor-beta	39,70	elastin	14,21	transforming growth factor-beta	elastin	7040	2006	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|Activation Activation|nmod|END_ENTITY	Activation of elastin transcription by transforming_growth_factor-beta in human lung fibroblasts .
3496959	0	transforming_growth_factor-beta	66,97	epidermal_growth_factor_receptor	14,46	transforming growth factor-beta	epidermal growth factor receptor	7040	1956	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Modulation of epidermal_growth_factor_receptor gene expression by transforming_growth_factor-beta in a human breast_carcinoma cell line .
9075708	0	transforming_growth_factor-beta	12,43	estrogen_receptor	65,82	transforming growth factor-beta	estrogen receptor	7040	2099	Gene	Gene	role|nmod|START_ENTITY role|nmod|regulation regulation|nmod|expression expression|compound|END_ENTITY	The role of transforming_growth_factor-beta in the regulation of estrogen_receptor expression in the MCF-7_breast_cancer cell line .
12379279	0	transforming_growth_factor-beta	82,113	glucocorticoid_receptor	14,37	transforming growth factor-beta	glucocorticoid receptor	7040	2908	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nsubj|Antagonism Antagonism|nmod|transactivity transactivity|amod|END_ENTITY	Antagonism of glucocorticoid_receptor transactivity and cell growth inhibition by transforming_growth_factor-beta through AP-1-mediated transcriptional repression .
12902338	0	transforming_growth_factor-beta	81,112	glucocorticoid_receptor	18,41	transforming growth factor-beta	glucocorticoid receptor	7040	2908	Gene	Gene	action|amod|START_ENTITY transrepression|nmod|action involved|nmod|transrepression involved|nsubj|Identification Identification|nmod|domains domains|compound|END_ENTITY	Identification of glucocorticoid_receptor domains involved in transrepression of transforming_growth_factor-beta action .
11715528	0	transforming_growth_factor-beta	22,53	glucose_transporter-1	67,88	transforming growth factor-beta	glucose transporter-1	7040	6513	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Modulatory effect of transforming_growth_factor-beta and Rhein on glucose_transporter-1 in human glomerular mesangial cells -RSB- .
8811049	0	transforming_growth_factor-beta	20,51	gp160	6,11	transforming growth factor-beta	gp160	7040	155971(Tax:11676)	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	HIV-1 gp160 induces transforming_growth_factor-beta production in human PBMC .
8163576	0	transforming_growth_factor-beta	86,117	heme_oxygenase-1	24,40	transforming growth factor-beta	heme oxygenase-1	7040	3162	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Increased expression of heme_oxygenase-1 in human retinal pigment epithelial cells by transforming_growth_factor-beta .
15716278	0	transforming_growth_factor-beta	110,141	inhibitor-1	39,50	transforming growth factor-beta	inhibitor-1	7040	5502	Gene	Gene	up-regulation|nmod|START_ENTITY END_ENTITY|nmod|up-regulation	Smad6s regulates plasminogen activator inhibitor-1 through a protein_kinase_C-beta-dependent up-regulation of transforming_growth_factor-beta .
7527411	0	transforming_growth_factor-beta	136,167	insulin-like_growth_factor-binding_protein-4	4,48	transforming growth factor-beta	insulin-like growth factor-binding protein-4	7040	3487	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|dep|regulation	The insulin-like_growth_factor-binding_protein-4 -LRB- IGFBP-4 -RRB- - IGFBP-4 protease system in normal human osteoblast-like cells : regulation by transforming_growth_factor-beta .
7627807	0	transforming_growth_factor-beta	48,79	interferon-gamma	10,26	transforming growth factor-beta	interferon-gamma	7040	3458	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of interferon-gamma on the expression of transforming_growth_factor-beta by human corneal fibroblasts : role in corneal immunoseclusion .
25633651	0	transforming_growth_factor-beta	44,75	interleukin-10	28,42	transforming growth factor-beta	interleukin-10	7040	3586	Gene	Gene	polymorphisms|amod|START_ENTITY polymorphisms|amod|END_ENTITY	Lack of association between interleukin-10 , transforming_growth_factor-beta gene polymorphisms and juvenile-onset_systemic_lupus_erythematosus .
10878024	0	transforming_growth_factor-beta	83,114	p21	54,57	transforming growth factor-beta	p21	7040	1026	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Role of Smad proteins and transcription factor Sp1 in p21 -LRB- Waf1/Cip1 -RRB- regulation by transforming_growth_factor-beta .
20398565	0	transforming_growth_factor-beta	84,115	p21	45,48	transforming growth factor-beta	p21	7040	1026	Gene	Gene	system|amod|START_ENTITY inhibited|nmod|system inhibited|dobj|expression expression|amod|END_ENTITY	-LSB- Platelet-derived growth factor-BB inhibited p21 -LRB- WAF1 -RRB- expression partially through transforming_growth_factor-beta signalling system in vascular smooth muscle cell -RSB- .
7727777	0	transforming_growth_factor-beta	17,48	p53	161,164	transforming growth factor-beta	p53	7040	7157	Gene	Gene	sensitivity|amod|START_ENTITY induces|dobj|sensitivity induces|parataxis|associated associated|nmod|downregulation downregulation|nmod|END_ENTITY	Anti-IgM induces transforming_growth_factor-beta sensitivity in a human B-lymphoma cell line : inhibition of growth is associated with a downregulation of mutant p53 .
11054406	0	transforming_growth_factor-beta	62,93	plasminogen_activator_inhibitor-1	14,47	transforming growth factor-beta	plasminogen activator inhibitor-1	7040	5054	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of plasminogen_activator_inhibitor-1 expression by transforming_growth_factor-beta - induced physical and functional interactions between smads and Sp1 .
11776328	0	transforming_growth_factor-beta	80,111	plasminogen_activator_inhibitor-1	27,60	transforming growth factor-beta	plasminogen activator inhibitor-1	7040	5054	Gene	Gene	activation|nmod|START_ENTITY activation|nsubj|mechanisms mechanisms|nmod|gene gene|amod|END_ENTITY	Differential mechanisms of plasminogen_activator_inhibitor-1 gene activation by transforming_growth_factor-beta and tumor_necrosis_factor-alpha in endothelial cells .
8179182	0	transforming_growth_factor-beta	13,44	plasminogen_activator_inhibitor-1	76,109	transforming growth factor-beta	plasminogen activator inhibitor-1	7040	5054	Gene	Gene	cells|amod|START_ENTITY assay|nmod|cells transfected|nsubj|assay transfected|nmod|construct construct|amod|END_ENTITY	An assay for transforming_growth_factor-beta using cells transfected with a plasminogen_activator_inhibitor-1 promoter-luciferase construct .
9792626	0	transforming_growth_factor-beta	29,60	plasminogen_activator_inhibitor-1	157,190	transforming growth factor-beta	plasminogen activator inhibitor-1	7040	5054	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|direct direct|nmod|element element|nmod|promoter promoter|amod|END_ENTITY	Smad4/DPC4 and Smad3 mediate transforming_growth_factor-beta -LRB- TGF-beta -RRB- signaling through direct binding to a novel TGF-beta-responsive element in the human plasminogen_activator_inhibitor-1 promoter .
8063785	0	transforming_growth_factor-beta	41,72	plasminogen_activator_inhibitor_type-1	99,137	transforming growth factor-beta	plasminogen activator inhibitor type-1	7040	5054	Gene	Gene	responsive|advmod|START_ENTITY element|amod|responsive element|nmod|gene gene|amod|END_ENTITY	A novel protein interacts with the major transforming_growth_factor-beta responsive element in the plasminogen_activator_inhibitor_type-1 gene .
10828062	0	transforming_growth_factor-beta	66,97	platelet-derived_growth_factor_B-chain	13,51	transforming growth factor-beta	platelet-derived growth factor B-chain	7040	5155	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of platelet-derived_growth_factor_B-chain expression by transforming_growth_factor-beta involves transactivation by Smads .
18158922	0	transforming_growth_factor-beta	27,58	podoplanin	13,23	transforming growth factor-beta	podoplanin	7040	10630	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of podoplanin by transforming_growth_factor-beta in human fibrosarcoma .
7706271	0	transforming_growth_factor-beta	14,45	thrombospondin_1	82,98	transforming growth factor-beta	thrombospondin 1	7040	7057	Gene	Gene	activation|amod|START_ENTITY Regulation|nmod|activation Regulation|nmod|END_ENTITY	Regulation of transforming_growth_factor-beta activation by discrete sequences of thrombospondin_1 .
8985117	0	transforming_growth_factor-beta	74,105	tissue_inhibitor_of_metalloproteinases-3	14,54	transforming growth factor-beta	tissue inhibitor of metalloproteinases-3	7040	282094(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of tissue_inhibitor_of_metalloproteinases-3 gene expression by transforming_growth_factor-beta and dexamethasone in bovine and human articular chondrocytes .
7560304	0	transforming_growth_factor-beta	72,103	transforming_growth_factor-beta_1	27,60	transforming growth factor-beta	transforming growth factor-beta 1	7040	7040	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Muscle fibre expression of transforming_growth_factor-beta_1 and latent transforming_growth_factor-beta binding protein in canine masticatory muscle_myositis .
12754205	0	transforming_growth_factor-beta	49,80	tristetraprolin	30,45	transforming growth factor-beta	tristetraprolin	7040	7538	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of tristetraprolin by transforming_growth_factor-beta in human T cells .
8077765	0	transforming_growth_factor-beta	86,117	tumor_necrosis_factor-alpha	38,65	transforming growth factor-beta	tumor necrosis factor-alpha	7040	7124	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of c-myc expression by tumor_necrosis_factor-alpha in combination with transforming_growth_factor-beta or interferon-gamma with concomitant inhibition of proliferation in human cell lines .
19861314	0	transforming_growth_factor-beta-1	28,61	VEGF	114,118	transforming growth factor-beta-1	VEGF	7040	7422	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Functional polymorphisms in transforming_growth_factor-beta-1 -LRB- TGFbeta-1 -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- genes modify risk of renal_parenchymal_scarring following childhood urinary_tract_infection .
19374881	0	transforming_growth_factor-beta1	51,83	Angiotensin_II	0,14	transforming growth factor-beta1	Angiotensin II	59086(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases collagen I expression via transforming_growth_factor-beta1 and extracellular_signal-regulated_kinase in cardiac fibroblasts .
16484225	0	transforming_growth_factor-beta1	44,76	CCN2	0,4	transforming growth factor-beta1	CCN2	21803(Tax:10090)	14219(Tax:10090)	Gene	Gene	necessary|nmod|START_ENTITY necessary|nsubj|END_ENTITY	CCN2 is necessary for adhesive responses to transforming_growth_factor-beta1 in embryonic fibroblasts .
12542531	0	transforming_growth_factor-beta1	57,89	CD34	121,125	transforming growth factor-beta1	CD34	7040	947	Gene	Gene	cooperation|nmod|START_ENTITY factor|nmod|cooperation induces|nsubj|factor induces|ccomp|+ +|nsubj|differentiation differentiation|nmod|END_ENTITY	Macrophage colony-stimulating factor in cooperation with transforming_growth_factor-beta1 induces the differentiation of CD34 + hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage_colony-stimulating_factor .
18473105	0	transforming_growth_factor-beta1	28,60	CD4	64,67	transforming growth factor-beta1	CD4	7040	920	Gene	Gene	START_ENTITY|nmod|CD25 CD25|compound|END_ENTITY	Expression of intracellular transforming_growth_factor-beta1 in CD4 + CD25 + cells in patients with systemic_lupus_erythematosus .
20438517	0	transforming_growth_factor-beta1	140,172	Connective_tissue_growth_factor	0,31	transforming growth factor-beta1	Connective tissue growth factor	7040	1490	Gene	Gene	cells|amod|START_ENTITY induced|nmod|cells production|acl|induced attenuated|dobj|production attenuated|nsubj|knockdown knockdown|compound|END_ENTITY	Connective_tissue_growth_factor knockdown attenuated matrix protein production and vascular_endothelial_growth_factor expression induced by transforming_growth_factor-beta1 in cultured human peritoneal mesothelial cells .
20553715	0	transforming_growth_factor-beta1	26,58	DEDD	0,4	transforming growth factor-beta1	DEDD	7040	9191	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	DEDD negatively regulates transforming_growth_factor-beta1 signaling by interacting with Smad3 .
16367920	0	transforming_growth_factor-beta1	71,103	E-cadherin	23,33	transforming growth factor-beta1	E-cadherin	7040	999	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Aberrant expression of E-cadherin and beta-catenin in association with transforming_growth_factor-beta1 in urinary_bladder_lesions in humans after the Chernobyl accident .
17376778	0	transforming_growth_factor-beta1	47,79	Endoglin	0,8	transforming growth factor-beta1	Endoglin	7040	2022	Gene	Gene	signaling|amod|START_ENTITY modulates|dobj|signaling modulates|nsubj|END_ENTITY	Endoglin differentially modulates antagonistic transforming_growth_factor-beta1 and BMP-7 signaling .
17113264	0	transforming_growth_factor-beta1	43,75	FAK	28,31	transforming growth factor-beta1	FAK	7040	5747	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Combinatorial activation of FAK and AKT by transforming_growth_factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts .
10098836	0	transforming_growth_factor-beta1	59,91	Glial_fibrillary_acidic_protein	0,31	transforming growth factor-beta1	Glial fibrillary acidic protein	59086(Tax:10116)	24387(Tax:10116)	Gene	Gene	responses|nmod|START_ENTITY responses|amod|END_ENTITY	Glial_fibrillary_acidic_protein transcription responses to transforming_growth_factor-beta1 and interleukin-1beta are mediated by a nuclear factor-1-like site in the near-upstream promoter .
19206163	0	transforming_growth_factor-beta1	66,98	PTEN	58,62	transforming growth factor-beta1	PTEN	7040	5728	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Post-transcriptional and post-translational regulation of PTEN by transforming_growth_factor-beta1 .
11145590	0	transforming_growth_factor-beta1	63,95	Pax-8	0,5	transforming growth factor-beta1	Pax-8	59086(Tax:10116)	81819(Tax:10116)	Gene	Gene	essential|advcl|START_ENTITY essential|nsubj|END_ENTITY	Pax-8 is essential for regulation of the thyroglobulin gene by transforming_growth_factor-beta1 .
20676968	0	transforming_growth_factor-beta1	112,144	Smad2	145,150	transforming growth factor-beta1	Smad2	59086(Tax:10116)	29357(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	The nonpeptide AVE0991 attenuates myocardial_hypertrophy as induced by angiotensin_II through downregulation of transforming_growth_factor-beta1 / Smad2 expression .
11438473	0	transforming_growth_factor-beta1	14,46	Smad3	84,89	transforming growth factor-beta1	Smad3	397078(Tax:9823)	397260(Tax:9823)	Gene	Gene	response|amod|START_ENTITY Alteration|nmod|response involves|nsubj|Alteration involves|dobj|down-regulation down-regulation|nmod|END_ENTITY	Alteration of transforming_growth_factor-beta1 response involves down-regulation of Smad3 signaling in myofibroblasts from skin fibrosis .
20553715	0	transforming_growth_factor-beta1	26,58	Smad3	89,94	transforming growth factor-beta1	Smad3	7040	4088	Gene	Gene	regulates|xcomp|START_ENTITY regulates|xcomp|signaling signaling|advcl|interacting interacting|nmod|END_ENTITY	DEDD negatively regulates transforming_growth_factor-beta1 signaling by interacting with Smad3 .
17567933	0	transforming_growth_factor-beta1	86,118	Specificity_protein_1	0,21	transforming growth factor-beta1	Specificity protein 1	7040	6667	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Specificity_protein_1 and Smad-dependent regulation of human heme_oxygenase-1 gene by transforming_growth_factor-beta1 in renal epithelial cells .
26753996	0	transforming_growth_factor-beta1	14,46	TGF-b1	48,54	transforming growth factor-beta1	TGF-b1	7040	7040	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of transforming_growth_factor-beta1 -LRB- TGF-b1 -RRB- - induced pro-fibrotic activities by circadian clock gene BMAL1 .
14769885	0	transforming_growth_factor-beta1	37,69	TGF-beta1	71,80	transforming growth factor-beta1	TGF-beta1	7040	7040	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Hepatitis_B virus X antigen promotes transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- activity by up-regulation of TGF-beta1 and down-regulation of alpha2-macroglobulin .
15288191	0	transforming_growth_factor-beta1	50,82	TGF-beta1	84,93	transforming growth factor-beta1	TGF-beta1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The promoter region -LRB- -800 , -509 -RRB- polymorphisms of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- gene and recurrent spontaneous_abortion .
9792792	0	transforming_growth_factor-beta1	70,102	TGF-beta1	104,113	transforming growth factor-beta1	TGF-beta1	7040	7040	Gene	Gene	mediates|amod|START_ENTITY mediates|appos|END_ENTITY	Upregulated expression of fibroblast growth factor -LRB- FGF -RRB- receptors by transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- mediates enhanced mitogenic responses to FGFs in cultured human lung fibroblasts .
11311337	0	transforming_growth_factor-beta1	26,58	TGFB1	60,65	transforming growth factor-beta1	TGFB1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence variation in the transforming_growth_factor-beta1 -LRB- TGFB1 -RRB- gene and multiple_sclerosis susceptibility .
22105716	0	transforming_growth_factor-beta1	103,135	Thrombospondin-1	0,16	transforming growth factor-beta1	Thrombospondin-1	21803(Tax:10090)	21825(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY regulator|nmod|activation regulator|nsubj|END_ENTITY	Thrombospondin-1 is a novel negative regulator of liver_regeneration after partial hepatectomy through transforming_growth_factor-beta1 activation in mice .
15653932	0	transforming_growth_factor-beta1	36,68	Tumor_necrosis_factor-alpha	0,27	transforming growth factor-beta1	Tumor necrosis factor-alpha	21803(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces transforming_growth_factor-beta1 expression in lung fibroblasts through the extracellular_signal-regulated_kinase pathway .
14769885	0	transforming_growth_factor-beta1	37,69	alpha2-macroglobulin	144,164	transforming growth factor-beta1	alpha2-macroglobulin	7040	2	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Hepatitis_B virus X antigen promotes transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- activity by up-regulation of TGF-beta1 and down-regulation of alpha2-macroglobulin .
9145908	0	transforming_growth_factor-beta1	10,42	aryl_hydrocarbon_receptor	60,85	transforming growth factor-beta1	aryl hydrocarbon receptor	7040	196	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of transforming_growth_factor-beta1 on expression of aryl_hydrocarbon_receptor and genes of Ah gene battery : clues for independent down-regulation in A549 cells .
19335981	0	transforming_growth_factor-beta1	79,111	beta-catenin	11,23	transforming growth factor-beta1	beta-catenin	7040	1499	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|nsubj|Effect Effect|nmod|END_ENTITY	-LSB- Effect of beta-catenin on the activation of hepatic stellate cells induced by transforming_growth_factor-beta1 -RSB- .
10576418	0	transforming_growth_factor-beta1	11,43	biglycan	79,87	transforming growth factor-beta1	biglycan	59086(Tax:10116)	25181(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effects of transforming_growth_factor-beta1 on the gene expression of decorin , biglycan , and alkaline phosphatase in osteoblast precursor cells and more differentiated osteoblast cells .
9135069	0	transforming_growth_factor-beta1	135,167	c-Fos	2,7	transforming growth factor-beta1	c-Fos	21803(Tax:10090)	14281(Tax:10090)	Gene	Gene	mediates|advcl|START_ENTITY mediates|nsubj|component component|amod|END_ENTITY	A c-Fos - and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming_growth_factor-beta1 .
17332318	0	transforming_growth_factor-beta1	137,169	c-fms	182,187	transforming growth factor-beta1	c-fms	7040	1436	Gene	Gene	START_ENTITY|advcl|inducing inducing|dobj|END_ENTITY	Elevated expression of the oncogene c-fms and its ligand , the macrophage colony-stimulating factor-1 , in cervical cancer and the role of transforming_growth_factor-beta1 in inducing c-fms expression .
10460009	0	transforming_growth_factor-beta1	59,91	c-fos	14,19	transforming growth factor-beta1	c-fos	59086(Tax:10116)	314322(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Regulation of c-fos gene induction and mitogenic effect of transforming_growth_factor-beta1 in rat articular chondrocyte .
12475893	0	transforming_growth_factor-beta1	37,69	connective_tissue_growth_factor	94,125	transforming growth factor-beta1	connective tissue growth factor	21803(Tax:10090)	14219(Tax:10090)	Gene	Gene	through|amod|START_ENTITY attenuation|amod|through attenuation|nmod|induction induction|compound|END_ENTITY	Hepatocyte_growth_factor counteracts transforming_growth_factor-beta1 , through attenuation of connective_tissue_growth_factor induction , and prevents renal fibrogenesis in 5/6 nephrectomized mice .
12760970	0	transforming_growth_factor-beta1	92,124	connective_tissue_growth_factor	49,80	transforming growth factor-beta1	connective tissue growth factor	7040	1490	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	C-Jun-NH2-terminal kinase mediates expression of connective_tissue_growth_factor induced by transforming_growth_factor-beta1 in human lung fibroblasts .
19210343	0	transforming_growth_factor-beta1	10,42	connective_tissue_growth_factor	64,95	transforming growth factor-beta1	connective tissue growth factor	7040	1490	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	Effect of transforming_growth_factor-beta1 on expression of the connective_tissue_growth_factor -LRB- CCN2/CTGF -RRB- gene in normal human gingival fibroblasts and periodontal ligament cells .
19466435	0	transforming_growth_factor-beta1	72,104	connective_tissue_growth_factor	118,149	transforming growth factor-beta1	connective tissue growth factor	7040	1490	Gene	Gene	induction|amod|START_ENTITY induction|nmod|matrix matrix|compound|END_ENTITY	Activation of peroxisome_proliferator-activated_receptor-gamma inhibits transforming_growth_factor-beta1 induction of connective_tissue_growth_factor and extracellular matrix in hypertrophic_scar_fibroblasts in vitro .
24224514	0	transforming_growth_factor-beta1	69,101	connective_tissue_growth_factor	36,67	transforming growth factor-beta1	connective tissue growth factor	59086(Tax:10116)	64032(Tax:10116)	Gene	Gene	localization|amod|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of connective_tissue_growth_factor , transforming_growth_factor-beta1 and phosphorylated-smad2 / 3 in the developing periodontium of rats .
9268374	0	transforming_growth_factor-beta1	44,76	cyclin_A	23,31	transforming growth factor-beta1	cyclin A	7040	890	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Down-regulation of the cyclin_A promoter by transforming_growth_factor-beta1 is associated with a reduction in phosphorylated activating_transcription_factor-1 and cyclic_AMP-responsive element-binding protein .
10877000	0	transforming_growth_factor-beta1	10,42	cytochrome_P450	46,61	transforming growth factor-beta1	cytochrome P450	59086(Tax:10116)	25251(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Effect of transforming_growth_factor-beta1 on cytochrome_P450 expression : inhibition of CYP1 mRNA and protein expression in primary rat hepatocytes .
20156938	0	transforming_growth_factor-beta1	85,117	endoglin	54,62	transforming growth factor-beta1	endoglin	59086(Tax:10116)	497010(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Mechanism Mechanism|nmod|effect effect|nmod|atorvastatin atorvastatin|nmod|expression expression|compound|END_ENTITY	Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming_growth_factor-beta1 in cultured cardiac fibroblasts .
10566662	0	transforming_growth_factor-beta1	14,46	granulocyte_macrophage-colony-stimulating_factor	61,109	transforming growth factor-beta1	granulocyte macrophage-colony-stimulating factor	7040	1437	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of transforming_growth_factor-beta1 expression by granulocyte_macrophage-colony-stimulating_factor in leiomyoma and myometrial smooth muscle cells .
17567933	0	transforming_growth_factor-beta1	86,118	heme_oxygenase-1	61,77	transforming growth factor-beta1	heme oxygenase-1	7040	3162	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|gene gene|amod|END_ENTITY	Specificity_protein_1 and Smad-dependent regulation of human heme_oxygenase-1 gene by transforming_growth_factor-beta1 in renal epithelial cells .
9721696	0	transforming_growth_factor-beta1	69,101	heme_oxygenase-1	13,29	transforming growth factor-beta1	heme oxygenase-1	59086(Tax:10116)	24451(Tax:10116)	Gene	Gene	downregulated|advcl|START_ENTITY downregulated|nsubjpass|Induction Induction|nmod|END_ENTITY	Induction of heme_oxygenase-1 during endotoxemia is downregulated by transforming_growth_factor-beta1 .
9670861	0	transforming_growth_factor-beta1	10,42	interleukin-6	46,59	transforming growth factor-beta1	interleukin-6	7040	3569	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of transforming_growth_factor-beta1 on interleukin-6 secretion in human myoblasts .
11423724	0	transforming_growth_factor-beta1	86,118	matrix_metalloproteinase-2	23,49	transforming growth factor-beta1	matrix metalloproteinase-2	59086(Tax:10116)	81686(Tax:10116)	Gene	Gene	cells|nmod|START_ENTITY decreases|nmod|cells decreases|dobj|activity activity|amod|END_ENTITY	High glucose decreases matrix_metalloproteinase-2 activity in rat mesangial cells via transforming_growth_factor-beta1 .
15226662	0	transforming_growth_factor-beta1	52,84	matrix_metalloproteinase-2	88,114	transforming growth factor-beta1	matrix metalloproteinase-2	7040	4313	Gene	Gene	START_ENTITY|nmod|activity activity|amod|END_ENTITY	Effect of cyclical mechanical stretch and exogenous transforming_growth_factor-beta1 on matrix_metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head .
9202299	0	transforming_growth_factor-beta1	80,112	nerve_growth_factor	116,135	transforming growth factor-beta1	nerve growth factor	7040	4803	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Effect of calcitriol in combination with corticosterone , interleukin-1beta , and transforming_growth_factor-beta1 on nerve_growth_factor secretion in an astroglial cell line .
9333119	0	transforming_growth_factor-beta1	12,44	osteogenic_protein-1	117,137	transforming growth factor-beta1	osteogenic protein-1	101006627	655	Gene	Gene	induces|nsubj|START_ENTITY induces|nmod|END_ENTITY	Recombinant transforming_growth_factor-beta1 induces endochondral bone_in_the_baboon_and_synergizes with recombinant osteogenic_protein-1 -LRB- bone_morphogenetic_protein-7 -RRB- to initiate rapid bone formation .
11911944	0	transforming_growth_factor-beta1	76,108	parathyroid_hormone-related_protein	27,62	transforming growth factor-beta1	parathyroid hormone-related protein	7040	5744	Gene	Gene	regulated|advcl|START_ENTITY regulated|nsubj|stability stability|nmod|END_ENTITY	Messenger RNA stability of parathyroid_hormone-related_protein regulated by transforming_growth_factor-beta1 .
14968437	0	transforming_growth_factor-beta1	11,43	parathyroid_hormone-related_protein	47,82	transforming growth factor-beta1	parathyroid hormone-related protein	7040	5744	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Effects of transforming_growth_factor-beta1 on parathyroid_hormone-related_protein mRNA expression and protein secretion in canine prostate epithelial , stromal , and carcinoma cells .
9741834	0	transforming_growth_factor-beta1	10,42	parathyroid_hormone-related_protein	46,81	transforming growth factor-beta1	parathyroid hormone-related protein	7040	5744	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effect of transforming_growth_factor-beta1 on parathyroid_hormone-related_protein secretion and mRNA expression by normal human keratinocytes in vitro .
10526273	0	transforming_growth_factor-beta1	18,50	vascular_endothelial_growth_factor	102,136	transforming growth factor-beta1	vascular endothelial growth factor	7040	7422	Gene	Gene	expression|nmod|START_ENTITY correlated|nsubj|expression correlated|nmod|expression expression|nmod|END_ENTITY	The expression of transforming_growth_factor-beta1 is significantly correlated with the expression of vascular_endothelial_growth_factor and poor prognosis of patients with advanced gastric_carcinoma .
15504975	0	transforming_growth_factor-beta1	114,146	vascular_endothelial_growth_factor	17,51	transforming growth factor-beta1	vascular endothelial growth factor	21803(Tax:10090)	22339(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Podocyte-derived vascular_endothelial_growth_factor mediates the stimulation of alpha3 -LRB- IV -RRB- collagen production by transforming_growth_factor-beta1 in mouse podocytes .
10567368	0	transforming_growth_factor-beta2	34,66	cAMP-responsive_element-binding_protein	79,118	transforming growth factor-beta2	cAMP-responsive element-binding protein	7042	1385	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Transcriptional regulation of the transforming_growth_factor-beta2 promoter by cAMP-responsive_element-binding_protein -LRB- CREB -RRB- and activating_transcription_factor-1 -LRB- ATF-1 -RRB- is modulated by protein kinases and the coactivators p300 and CREB-binding_protein .
15196415	0	transforming_growth_factor-beta2	14,46	tumor_necrosis_factor-alpha	64,91	transforming growth factor-beta2	tumor necrosis factor-alpha	7042	7124	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of transforming_growth_factor-beta2 on production of tumor_necrosis_factor-alpha and interferon-gamma from placenta of intrahepatic_cholestasis_of_pregnancy -RSB- .
18005096	0	transforming_growth_factor-beta_1	143,176	Alpha-smooth_muscle_actin	0,25	transforming growth factor-beta 1	Alpha-smooth muscle actin	59086(Tax:10116)	25365(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Alpha-smooth_muscle_actin -LRB- alpha-SMA -RRB- and nestin expression in reactive astrocytes in multiple_sclerosis lesions : potential regulatory role of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- .
8645162	0	transforming_growth_factor-beta_1	42,75	Betaglycan	0,10	transforming growth factor-beta 1	Betaglycan	7040	7049	Gene	Gene	sites|nmod|START_ENTITY has|dobj|sites has|nsubj|END_ENTITY	Betaglycan has multiple binding sites for transforming_growth_factor-beta_1 .
7912547	0	transforming_growth_factor-beta_1	23,56	CD4	101,104	transforming growth factor-beta 1	CD4	7040	920	Gene	Gene	T|amod|START_ENTITY T|compound|END_ENTITY	Differential effect of transforming_growth_factor-beta_1 on the activation of human naive and memory CD4 + T lymphocytes .
8642767	0	transforming_growth_factor-beta_1	27,60	CD4	181,184	transforming growth factor-beta 1	CD4	7040	920	Gene	Gene	level|amod|START_ENTITY level|appos|CD3 CD3|dep|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
8675229	0	transforming_growth_factor-beta_1	29,62	CD4	99,102	transforming growth factor-beta 1	CD4	7040	920	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	Growth regulatory effects of transforming_growth_factor-beta_1 and interleukin-2 on IL-2 dependent CD4 + T lymphoblastoid cell line .
8642767	0	transforming_growth_factor-beta_1	27,60	CD8	186,189	transforming growth factor-beta 1	CD8	7040	925	Gene	Gene	level|amod|START_ENTITY level|appos|CD3 CD3|dep|END_ENTITY	-LSB- Measurement of the plasma transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- level in patients of gastric_carcinoma -- compared with the serum IAP level and the lymphocyte subsets -LRB- CD3 , CD4 , CD8 -RRB- -RSB- .
8468369	0	transforming_growth_factor-beta_1	64,97	Hsp70	22,27	transforming growth factor-beta 1	Hsp70	100873157	423504(Tax:9031)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of chicken Hsp70 and Hsp90 family gene expression by transforming_growth_factor-beta_1 .
12468382	0	transforming_growth_factor-beta_1	11,44	SPARC	64,69	transforming growth factor-beta 1	SPARC	7040	6678	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of transforming_growth_factor-beta_1 and fibronectin on SPARC expression in cultures of human periodontal ligament cells .
21529804	0	transforming_growth_factor-beta_1	9,42	TGF-b1	44,50	transforming growth factor-beta 1	TGF-b1	7040	7040	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Elevated transforming_growth_factor-beta_1 -LRB- TGF-b1 -RRB- levels in human fracture healing .
24310505	0	transforming_growth_factor-beta_1	31,64	TGF-b1	66,72	transforming growth factor-beta 1	TGF-b1	7040	7040	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Clinical significance of serum transforming_growth_factor-beta_1 -LRB- TGF-b1 -RRB- levels in patients with epithelial_ovarian_cancer .
24771267	0	transforming_growth_factor-beta_1	6,39	TGF-b1	41,47	transforming growth factor-beta 1	TGF-b1	7040	7040	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum transforming_growth_factor-beta_1 -LRB- TGF-b1 -RRB- levels have diagnostic , predictive , and possible prognostic roles in patients with melanoma .
11730838	0	transforming_growth_factor-beta_1	12,45	TGF-beta1	47,56	transforming growth factor-beta 1	TGF-beta1	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- expression in human monocytes infected with Mycobacterium_avium at a single cell level by ELISPOT assay .
12358852	0	transforming_growth_factor-beta_1	40,73	TGF-beta1	75,84	transforming growth factor-beta 1	TGF-beta1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in codons 10 and 25 of the transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- gene in patients with invasive squamous_cell_carcinoma_of_the_uterine_cervix .
9717976	0	transforming_growth_factor-beta_1	77,110	TGF-beta1	112,121	transforming growth factor-beta 1	TGF-beta1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Aminoguanidine reduces glomerular inducible_nitric_oxide_synthase -LRB- iNOS -RRB- and transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- mRNA expression and diminishes glomerulosclerosis in NZB/W F1 mice .
1851752	0	transforming_growth_factor-beta_1	27,60	TGF-beta_1	62,72	transforming growth factor-beta 1	TGF-beta 1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Differential expression of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- receptors in murine myeloid cell lines transformed with oncogenes .
7729516	0	transforming_growth_factor-beta_1	23,56	TGF-beta_1	11,21	transforming growth factor-beta 1	TGF-beta 1	7040	7040	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of TGF-beta_1 -LRB- transforming_growth_factor-beta_1 -RRB- on the cell cycle regulation of human breast_adenocarcinoma -LRB- MCF-7 -RRB- cells .
7980578	0	transforming_growth_factor-beta_1	14,47	TGF-beta_1	49,59	transforming growth factor-beta 1	TGF-beta 1	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression with a novel TGF-beta_1 complementary DNA .
7980578	0	transforming_growth_factor-beta_1	14,47	TGF-beta_1	85,95	transforming growth factor-beta 1	TGF-beta 1	7040	7040	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression END_ENTITY|nsubj|Regulation	Regulation of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- expression with a novel TGF-beta_1 complementary DNA .
8050182	0	transforming_growth_factor-beta_1	30,63	TGF-beta_1	65,75	transforming growth factor-beta 1	TGF-beta 1	7040	7040	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Intraglomerular expression of transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- mRNA in patients with glomerulonephritis : quantitative analysis by competitive polymerase chain reaction .
8086280	0	transforming_growth_factor-beta_1	84,117	TGF-beta_1	119,129	transforming growth factor-beta 1	TGF-beta 1	100008645(Tax:9986)	100008645(Tax:9986)	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Different phosphorylated forms of inositolphosphate_glycan could be involved in the transforming_growth_factor-beta_1 -LRB- TGF-beta_1 -RRB- signalling pathway .
12938093	0	transforming_growth_factor-beta_1	36,69	TGFB1	71,76	transforming growth factor-beta 1	TGFB1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of novel variants in transforming_growth_factor-beta_1 -LRB- TGFB1 -RRB- gene and association analysis with bone mineral density .
1370602	0	transforming_growth_factor-beta_1	11,44	alpha_2-macroglobulin	66,87	transforming growth factor-beta 1	alpha 2-macroglobulin	7040	2	Gene	Gene	immobilized|amod|START_ENTITY END_ENTITY|amod|immobilized	Binding of transforming_growth_factor-beta_1 to immobilized human alpha_2-macroglobulin .
1718991	0	transforming_growth_factor-beta_1	15,48	alpha_2-macroglobulin	54,75	transforming growth factor-beta 1	alpha 2-macroglobulin	21803(Tax:10090)	232345(Tax:10090)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of transforming_growth_factor-beta_1 with alpha_2-macroglobulin .
7492983	0	transforming_growth_factor-beta_1	30,63	angiotensin_II	8,22	transforming growth factor-beta 1	angiotensin II	59086(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Role of angiotensin_II in the transforming_growth_factor-beta_1 expression of rat kidney in anti-glomerular basement membrane antiserum-induced glomerulonephritis .
1380512	0	transforming_growth_factor-beta_1	28,61	carcinoembryonic_antigen	75,99	transforming growth factor-beta 1	carcinoembryonic antigen	7040	1084	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	Role of protein_kinase_C in transforming_growth_factor-beta_1 induction of carcinoembryonic_antigen in human colon_carcinoma cells .
15975819	0	transforming_growth_factor-beta_1	80,113	interleukin-8	23,36	transforming growth factor-beta 1	interleukin-8	7040	3576	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|expression expression|amod|END_ENTITY	Selective induction of interleukin-8 expression in metastatic melanoma cells by transforming_growth_factor-beta_1 .
8768866	0	transforming_growth_factor-beta_1	143,176	interleukin-8	73,86	transforming growth factor-beta 1	interleukin-8	7040	3576	Gene	Gene	synthesis|advcl|START_ENTITY synthesis|amod|END_ENTITY	Modulation of the levels of interleukin-8 messenger ribonucleic_acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming_growth_factor-beta_1 .
12127997	0	transforming_growth_factor-beta_1	66,99	monocyte_chemoattractant_protein_1	16,50	transforming growth factor-beta 1	monocyte chemoattractant protein 1	7040	6347	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of monocyte_chemoattractant_protein_1 and effects of transforming_growth_factor-beta_1 in Peyronie 's _ disease .
7560304	0	transforming_growth_factor-beta_1	27,60	transforming_growth_factor-beta	72,103	transforming growth factor-beta 1	transforming growth factor-beta	7040	7040	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Muscle fibre expression of transforming_growth_factor-beta_1 and latent transforming_growth_factor-beta binding protein in canine masticatory muscle_myositis .
2808430	0	transforming_growth_factor-beta_1	41,74	transforming_growth_factor-beta_1	83,116	transforming growth factor-beta 1	transforming growth factor-beta 1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Activation of the second promoter of the transforming_growth_factor-beta_1 gene by transforming_growth_factor-beta_1 and phorbol_ester occurs through the same target sequences .
2808430	0	transforming_growth_factor-beta_1	83,116	transforming_growth_factor-beta_1	41,74	transforming growth factor-beta 1	transforming growth factor-beta 1	7040	7040	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Activation of the second promoter of the transforming_growth_factor-beta_1 gene by transforming_growth_factor-beta_1 and phorbol_ester occurs through the same target sequences .
1280203	0	transforming_growth_factor-beta_2	39,72	TGF-beta_2	74,84	transforming growth factor-beta 2	TGF-beta 2	81809(Tax:10116)	81809(Tax:10116)	Gene	Gene	messenger|amod|START_ENTITY messenger|appos|END_ENTITY	Porcine granulosa cells do not express transforming_growth_factor-beta_2 -LRB- TGF-beta_2 -RRB- messenger ribonucleic_acid : molecular basis for their inability to produce TGF-beta activity comparable to that of rat granulosa cells .
20848923	0	transforming_growth_factor-beta_3	26,59	activin_receptor-like_kinase_5	61,91	transforming growth factor-beta 3	activin receptor-like kinase 5	21809(Tax:10090)	21812(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	-LSB- The preliminary study on transforming_growth_factor-beta_3 , activin_receptor-like_kinase_5 expression in 2 , 3 , 7 , 8-tetrachloro-p-dibenzodioxin and dexamethasone induced palatal_cleft in mice -RSB- .
9524286	0	transforming_growth_factor-beta_5	65,98	TGF-beta_5	100,110	transforming growth factor-beta 5	TGF-beta 5	397778(Tax:8355)	397778(Tax:8355)	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	Characterization of the 5 ' flanking region of the Xenopus_laevis transforming_growth_factor-beta_5 -LRB- TGF-beta_5 -RRB- gene .
16083599	0	transforming_growth_factor-beta_receptor_II	59,102	Smad4	15,20	transforming growth factor-beta receptor II	Smad4	7048	4089	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	-LSB- Expression of Smad4 and transforming_growth_factor-beta1 , transforming_growth_factor-beta_receptor_II in cholangiocarcinoma tissue and its biological significance -RSB- .
11496185	0	transforming_growth_factor-beta_receptors_I_and_II	27,77	Smad_3	96,102	transforming growth factor-beta receptors I and II	Smad 3	7046;7048	4088	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of transforming_growth_factor-beta_receptors_I_and_II and activation of Smad_3 in keloid fibroblasts .
10226558	0	transforming_growth_factor-beta_type_II_receptor	8,56	TGF-beta_RII	58,70	transforming growth factor-beta type II receptor	TGF-beta RII	7048	7048	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Reduced transforming_growth_factor-beta_type_II_receptor -LRB- TGF-beta_RII -RRB- expression in adenocarcinoma_of_the_lung .
12414627	0	transforming_growth_factor_Beta	15,46	smad4	85,90	transforming growth factor Beta	smad4	7040	4089	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|expression expression|nmod|END_ENTITY	Restoration of transforming_growth_factor_Beta signaling by functional expression of smad4 induces anoikis .
8179588	0	transforming_growth_factor_alpha	35,67	Hepatocyte_growth_factor	0,24	transforming growth factor alpha	Hepatocyte growth factor	7124	3082	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Hepatocyte_growth_factor regulates transforming_growth_factor_alpha in HepG2 hepatic cells .
8100806	0	transforming_growth_factor_alpha	22,54	Igk	65,68	transforming growth factor alpha	Igk	21802(Tax:10090)	243469(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|nmod|END_ENTITY	Linkage of the murine transforming_growth_factor_alpha gene with Igk , Ly-2 , and Fabp1 on chromosome 6 .
10369712	0	transforming_growth_factor_alpha	61,93	TFF1	13,17	transforming growth factor alpha	TFF1	21802(Tax:10090)	21784(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of TFF1 gene expression in pancreas overexpressing transforming_growth_factor_alpha .
10221672	0	transforming_growth_factor_alpha	10,42	TGF-alpha	44,53	transforming growth factor alpha	TGF-alpha	7124	7039	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- in human cerebrospinal fluid .
7858746	0	transforming_growth_factor_alpha	11,43	TGF-alpha	45,54	transforming growth factor alpha	TGF-alpha	7124	7039	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- on DNA synthesis and thyrotropin-induced iodine metabolism in cultured porcine thyroid cells .
8455929	0	transforming_growth_factor_alpha	8,40	TGF-alpha	42,51	transforming growth factor alpha	TGF-alpha	24827(Tax:10116)	24827(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- in the transformation of ras-transfected rat intestinal epithelial cells .
9147239	0	transforming_growth_factor_alpha	14,46	TGF-alpha	48,57	transforming growth factor alpha	TGF-alpha	21802(Tax:10090)	21802(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- gene in mouse embryonic development .
9399568	0	transforming_growth_factor_alpha	16,48	TGF-alpha	50,59	transforming growth factor alpha	TGF-alpha	7124	7039	Gene	Gene	Construction|nmod|START_ENTITY Construction|appos|END_ENTITY	Construction of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- phage library and identification of high binders of epidermal_growth_factor_receptor -LRB- EGFR -RRB- by phage display .
9820173	0	transforming_growth_factor_alpha	33,65	TGF-alpha	67,76	transforming growth factor alpha	TGF-alpha	7124	7039	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Lack of interleukin_6 -LRB- IL-6 -RRB- and transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- expression in chromophobe renal_cell_carcinomas .
1524218	0	transforming_growth_factor_alpha	76,108	TGF_alpha	110,119	transforming growth factor alpha	TGF alpha	7124	7039	Gene	Gene	modulators|nmod|START_ENTITY modulators|appos|END_ENTITY	Characterization of a scintillation proximity assay to detect modulators of transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- binding .
2043488	0	transforming_growth_factor_alpha	14,46	TGF_alpha	48,57	transforming growth factor alpha	TGF alpha	7124	7039	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- in breast_cancer .
2324504	0	transforming_growth_factor_alpha	61,93	TGF_alpha	95,104	transforming growth factor alpha	TGF alpha	7124	7039	Gene	Gene	assay|nmod|START_ENTITY assay|appos|END_ENTITY	A new sandwich enzyme-linked immunosorbent assay -LRB- ELISA -RRB- for transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- based upon conformational modification by antibody binding .
7702037	0	transforming_growth_factor_alpha	21,53	TGF_alpha	55,64	transforming growth factor alpha	TGF alpha	7124	7039	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Association study of transforming_growth_factor_alpha -LRB- TGF_alpha -RRB- TaqI polymorphism and oral clefts : indication of gene-environment interaction in a population-based sample of infants with birth_defects .
8360257	0	transforming_growth_factor_alpha	14,46	TGF_alpha	106,115	transforming growth factor alpha	TGF alpha	7124	7039	Gene	Gene	mRNA|compound|START_ENTITY Expression|nmod|mRNA inhibits|nsubj|Expression inhibits|dobj|production production|nmod|END_ENTITY	Expression of transforming_growth_factor_alpha antisense mRNA inhibits the estrogen-induced production of TGF_alpha and estrogen-induced proliferation of estrogen-responsive human breast_cancer cells .
8430098	0	transforming_growth_factor_alpha	54,86	Tumor_necrosis_factor_alpha	0,27	transforming growth factor alpha	Tumor necrosis factor alpha	7124	7124	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha induces the expression of transforming_growth_factor_alpha and the epidermal_growth_factor_receptor in human pancreatic_cancer cells .
2433030	0	transforming_growth_factor_alpha	13,45	epidermal_growth_factor	74,97	transforming growth factor alpha	epidermal growth factor	7124	1950	Gene	Gene	Elevation|nmod|START_ENTITY Elevation|nmod|END_ENTITY	Elevation of transforming_growth_factor_alpha and its relationship to the epidermal_growth_factor and alpha-fetoprotein levels in patients with hepatocellular_carcinoma .
10436007	0	transforming_growth_factor_alpha	29,61	epidermal_growth_factor_receptor	76,108	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	release|nmod|START_ENTITY activates|nsubj|release activates|dobj|END_ENTITY	Radiation-induced release of transforming_growth_factor_alpha activates the epidermal_growth_factor_receptor and mitogen-activated protein kinase pathway in carcinoma cells , leading to increased proliferation and protection from radiation-induced cell death .
10621852	0	transforming_growth_factor_alpha	31,63	epidermal_growth_factor_receptor	65,97	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	neu|dep|START_ENTITY neu|dep|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
10924142	0	transforming_growth_factor_alpha	48,80	epidermal_growth_factor_receptor	90,122	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	START_ENTITY|nmod|domain domain|compound|END_ENTITY	Real-time kinetic studies on the interaction of transforming_growth_factor_alpha with the epidermal_growth_factor_receptor extracellular domain reveal a conformational change model .
11522647	0	transforming_growth_factor_alpha	100,132	epidermal_growth_factor_receptor	67,99	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	expression|compound|START_ENTITY kinases|dep|expression kinases|dep|association association|nmod|END_ENTITY	Activated extracellular signal-regulated kinases : association with epidermal_growth_factor_receptor / transforming_growth_factor_alpha expression in head and neck squamous_carcinoma and inhibition by anti-epidermal_growth_factor_receptor treatments .
12297049	0	transforming_growth_factor_alpha	96,128	epidermal_growth_factor_receptor	33,65	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	bound|nmod|START_ENTITY bound|nsubj|structure structure|nmod|domain domain|compound|END_ENTITY	Crystal structure of a truncated epidermal_growth_factor_receptor extracellular domain bound to transforming_growth_factor_alpha .
1390737	0	transforming_growth_factor_alpha	23,55	epidermal_growth_factor_receptor	63,95	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Multidomain binding of transforming_growth_factor_alpha to the epidermal_growth_factor_receptor .
14519647	0	transforming_growth_factor_alpha	102,134	epidermal_growth_factor_receptor	135,167	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	abrogation|nmod|START_ENTITY retinoid|nmod|abrogation Responsiveness|acl|retinoid Responsiveness|parataxis|signaling signaling|nsubj|autocrine autocrine|compound|END_ENTITY	Responsiveness to the retinoic_acid receptor-selective retinoid LGD1550 correlates with abrogation of transforming_growth_factor_alpha / epidermal_growth_factor_receptor autocrine signaling in head and neck squamous_carcinoma cells .
1677800	1	transforming_growth_factor_alpha	119,151	epidermal_growth_factor_receptor	152,184	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	effects|nmod|START_ENTITY Inhibition|nmod|effects Inhibition|parataxis|pathways pathways|nsubj|END_ENTITY	Inhibition of keratinocyte cell-cycle progression in G1 independent of effects on transforming_growth_factor_alpha / epidermal_growth_factor_receptor pathways .
1718591	0	transforming_growth_factor_alpha	15,47	epidermal_growth_factor_receptor	48,80	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|mechanism mechanism|amod|END_ENTITY	Involvement of transforming_growth_factor_alpha / epidermal_growth_factor_receptor autocrine growth mechanism in an ovarian_cancer cell line in vitro .
1933859	0	transforming_growth_factor_alpha	14,46	epidermal_growth_factor_receptor	47,79	transforming growth factor alpha	epidermal growth factor receptor	21802(Tax:10090)	13649(Tax:10090)	Gene	Gene	Importance|nmod|START_ENTITY Importance|dep|mechanism mechanism|amod|END_ENTITY	Importance of transforming_growth_factor_alpha / epidermal_growth_factor_receptor autocrine growth mechanism in an ovarian_cancer cell line in vivo .
7519440	0	transforming_growth_factor_alpha	79,111	epidermal_growth_factor_receptor	112,144	transforming growth factor alpha	epidermal growth factor receptor	24827(Tax:10116)	24329(Tax:10116)	Gene	Gene	START_ENTITY|dep|alpha alpha|dep|receptors receptors|compound|END_ENTITY	Hepatic regeneration in vitamin_A-deficient rats : changes in the expression of transforming_growth_factor_alpha / epidermal_growth_factor_receptor and retinoic_acid receptors alpha and beta .
7728756	0	transforming_growth_factor_alpha	10,42	epidermal_growth_factor_receptor	134,166	transforming growth factor alpha	epidermal growth factor receptor	21802(Tax:10090)	13649(Tax:10090)	Gene	Gene	dispensible|nsubj|START_ENTITY dispensible|nmod|neoplasia neoplasia|dep|involvement involvement|nmod|ligands ligands|compound|END_ENTITY	Autocrine transforming_growth_factor_alpha is dispensible for v-rasHa-induced epidermal neoplasia : potential involvement of alternate epidermal_growth_factor_receptor ligands .
7829492	0	transforming_growth_factor_alpha	20,52	epidermal_growth_factor_receptor	104,136	transforming growth factor alpha	epidermal growth factor receptor	414743(Tax:9031)	396494(Tax:9031)	Gene	Gene	Contribution|nmod|START_ENTITY B-loop|nsubj|Contribution B-loop|xcomp|beta-sheet beta-sheet|nmod|binding binding|nmod|END_ENTITY	Contribution of the transforming_growth_factor_alpha B-loop beta-sheet to binding and activation of the epidermal_growth_factor_receptor .
7947089	0	transforming_growth_factor_alpha	85,117	epidermal_growth_factor_receptor	118,150	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	pathway|amod|START_ENTITY pathway|compound|END_ENTITY	Autocrine stimulation of a human lung_mesothelioma cell line is mediated through the transforming_growth_factor_alpha / epidermal_growth_factor_receptor mitogenic pathway .
8879184	0	transforming_growth_factor_alpha	39,71	epidermal_growth_factor_receptor	101,133	transforming growth factor alpha	epidermal growth factor receptor	21802(Tax:10090)	13649(Tax:10090)	Gene	Gene	mice|compound|START_ENTITY Reversal_of_lung_lesions|nmod|mice Reversal_of_lung_lesions|nmod|END_ENTITY	Reversal_of_lung_lesions in transgenic transforming_growth_factor_alpha mice by expression of mutant epidermal_growth_factor_receptor .
9100135	0	transforming_growth_factor_alpha	74,106	epidermal_growth_factor_receptor	25,57	transforming growth factor alpha	epidermal growth factor receptor	24827(Tax:10116)	24329(Tax:10116)	Gene	Gene	ontogeny|appos|START_ENTITY ontogeny|nmod|END_ENTITY	Prenatal ontogeny of the epidermal_growth_factor_receptor and its ligand , transforming_growth_factor_alpha , in the rat brain .
9399568	0	transforming_growth_factor_alpha	16,48	epidermal_growth_factor_receptor	113,145	transforming growth factor alpha	epidermal growth factor receptor	7124	1956	Gene	Gene	Construction|nmod|START_ENTITY phage|nsubj|Construction phage|dobj|library library|nmod|binders binders|nmod|END_ENTITY	Construction of transforming_growth_factor_alpha -LRB- TGF-alpha -RRB- phage library and identification of high binders of epidermal_growth_factor_receptor -LRB- EGFR -RRB- by phage display .
11421874	0	transforming_growth_factor_alpha	40,72	hepatocyte_growth_factor	14,38	transforming growth factor alpha	hepatocyte growth factor	7124	3082	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of hepatocyte_growth_factor , transforming_growth_factor_alpha , apoptosis related proteins Bax and Bcl-2 , and gastrin in human gastric_cancer .
8640940	0	transforming_growth_factor_alpha	14,46	hepatocyte_growth_factor	81,105	transforming growth factor alpha	hepatocyte growth factor	7124	3082	Gene	Gene	START_ENTITY|dep|epidermal_growth_factor_receptor epidermal_growth_factor_receptor|appos|END_ENTITY	Expression of transforming_growth_factor_alpha / epidermal_growth_factor_receptor , hepatocyte_growth_factor / c-met and acidic_fibroblast_growth_factor / fibroblast growth factor receptors during hepatocarcinogenesis .
7473417	0	transforming_growth_factor_alpha	62,94	insulin-like_growth_factor_I	11,39	transforming growth factor alpha	insulin-like growth factor I	414743(Tax:9031)	100327329(Tax:9031)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of insulin-like_growth_factor_I and interactions with transforming_growth_factor_alpha and LH on proliferation of chicken granulosa cells and production of progesterone in culture .
2263621	0	transforming_growth_factor_alpha	15,47	luteinizing_hormone-releasing_hormone	66,103	transforming growth factor alpha	luteinizing hormone-releasing hormone	24827(Tax:10116)	25194(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of transforming_growth_factor_alpha in the release of luteinizing_hormone-releasing_hormone from the developing female hypothalamus .
16581947	0	transforming_growth_factor_alpha	101,133	nuclear_factor-kappaB	163,184	transforming growth factor alpha	nuclear factor-kappaB	7124	4790	Gene	Gene	expression|compound|START_ENTITY expression|nmod|activation activation|nmod|END_ENTITY	Hepatitis_C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming_growth_factor_alpha expression via activation of nuclear_factor-kappaB .
10621852	0	transforming_growth_factor_alpha	31,63	p53	26,29	transforming growth factor alpha	p53	7124	7157	Gene	Gene	neu|dep|START_ENTITY neu|compound|END_ENTITY	Expression of biomarkers -LRB- p53 , transforming_growth_factor_alpha , epidermal_growth_factor_receptor , c-erbB-2 / neu and the proliferative cell nuclear antigen -RRB- in oropharyngeal_squamous_cell_carcinomas .
23816882	0	transforming_growth_factor_b	29,57	CTGF	0,4	transforming growth factor b	CTGF	21803(Tax:10090)	14219(Tax:10090)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	CTGF mediates Smad-dependent transforming_growth_factor_b signaling to regulate mesenchymal cell proliferation during palate development .
22549363	0	transforming_growth_factor_b	56,84	JAK-2	0,5	transforming growth factor b	JAK-2	7040	3717	Gene	Gene	effects|nmod|START_ENTITY END_ENTITY|nmod|effects	JAK-2 as a novel mediator of the profibrotic effects of transforming_growth_factor_b in systemic_sclerosis .
21081531	0	transforming_growth_factor_b	20,48	TGF-b	49,54	transforming growth factor b	TGF-b	7040	7040	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Altered dynamics of transforming_growth_factor_b -LRB- TGF-b -RRB- receptors in scleroderma fibroblasts .
23212909	0	transforming_growth_factor_b	56,84	four_and_a_half_LIM-only_protein_2	4,38	transforming growth factor b	four and a half LIM-only protein 2	7040	2274	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	The four_and_a_half_LIM-only_protein_2 -LRB- FHL2 -RRB- activates transforming_growth_factor_b -LRB- TGF-b -RRB- signaling by regulating ubiquitination of the E3 ligase Arkadia .
26114584	0	transforming_growth_factor_b-activated_kinase_1	62,109	TAK1	111,115	transforming growth factor b-activated kinase 1	TAK1	6885	6885	Gene	Gene	inhibition|amod|START_ENTITY inhibition|appos|END_ENTITY	Disruption of thioredoxin metabolism enhances the toxicity of transforming_growth_factor_b-activated_kinase_1 -LRB- TAK1 -RRB- inhibition in KRAS-mutated colon_cancer cells .
22883070	0	transforming_growth_factor_b1	52,81	C-reactive_protein	12,30	transforming growth factor b1	C-reactive protein	7040	1401	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effects of C-reactive_protein on the expression of transforming_growth_factor_b1 and receptors on human renal tubular epithelial cells -RSB- .
23572561	0	transforming_growth_factor_b1	20,49	LOXL4	0,5	transforming growth factor b1	LOXL4	7040	84171	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	LOXL4 is induced by transforming_growth_factor_b1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling .
21468608	0	transforming_growth_factor_b1	83,112	Smad2	0,5	transforming growth factor b1	Smad2	7040	4087	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Smad2 and Smad3 as mediators of the response of adventitial fibroblasts induced by transforming_growth_factor_b1 .
23917667	0	transforming_growth_factor_b1	26,55	TGFb1	57,62	transforming growth factor b1	TGFb1	282089(Tax:9913)	282089(Tax:9913)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin_10 -LRB- IL10 -RRB- and transforming_growth_factor_b1 -LRB- TGFb1 -RRB- gene polymorphisms in persistent IgE-mediated cow 's milk_allergy .
24628581	0	transforming_growth_factor_b1	34,63	TGFb1	65,70	transforming growth factor b1	TGFb1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Potential neuroprotective role of transforming_growth_factor_b1 -LRB- TGFb1 -RRB- in the brain .
15993878	0	transforming_growth_factor_beta	57,88	ALK5	103,107	transforming growth factor beta	ALK5	7040	7046	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Altered primordial germ cell migration in the absence of transforming_growth_factor_beta signaling via ALK5 .
10938097	0	transforming_growth_factor_beta	21,52	BF-1	0,4	transforming growth factor beta	BF-1	7040	2290	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	BF-1 interferes with transforming_growth_factor_beta signaling by associating with Smad partners .
11243465	0	transforming_growth_factor_beta	14,45	Bcl-2	136,141	transforming growth factor beta	Bcl-2	7040	596	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|role role|nmod|END_ENTITY	Inhibition of transforming_growth_factor_beta signaling in MCF-7 cells results in resistance to tumor_necrosis_factor_alpha : a role for Bcl-2 .
17030617	0	transforming_growth_factor_beta	13,44	Cripto	0,6	transforming growth factor beta	Cripto	7040	6997	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Cripto binds transforming_growth_factor_beta -LRB- TGF-beta -RRB- and inhibits TGF-beta signaling .
16616811	0	transforming_growth_factor_beta	52,83	Cyr61	10,15	transforming growth factor beta	Cyr61	7040	3491	Gene	Gene	target|nmod|START_ENTITY target|nsubj|gene gene|amod|END_ENTITY	The human Cyr61 gene is a transcriptional target of transforming_growth_factor_beta in cancer cells .
15037657	0	transforming_growth_factor_beta	23,54	Cystatin_C	0,10	transforming growth factor beta	Cystatin C	7040	1471	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Cystatin_C antagonizes transforming_growth_factor_beta signaling in normal and cancer cells .
9895299	0	transforming_growth_factor_beta	29,60	Dermatopontin	0,13	transforming growth factor beta	Dermatopontin	7040	1805	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Dermatopontin interacts with transforming_growth_factor_beta and enhances its biological activity .
10974035	0	transforming_growth_factor_beta	44,75	E-selectin	14,24	transforming growth factor beta	E-selectin	7040	6401	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of E-selectin gene expression by transforming_growth_factor_beta in endothelial cells involves coactivator integration of Smad and nuclear_factor_kappaB-mediated signals .
8587240	0	transforming_growth_factor_beta	94,125	EDA	72,75	transforming growth factor beta	EDA	7040	1896	Gene	Gene	variant|nmod|START_ENTITY variant|compound|END_ENTITY	Fibronectin synthesis in tubular epithelial cells : up-regulation of the EDA splice variant by transforming_growth_factor_beta .
17591701	0	transforming_growth_factor_beta	15,46	Erbin	0,5	transforming growth factor beta	Erbin	7040	55914	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Erbin inhibits transforming_growth_factor_beta signaling through a novel Smad-interacting_domain .
17038665	0	transforming_growth_factor_beta	37,68	Fibroblast_growth_factor_2	0,26	transforming growth factor beta	Fibroblast growth factor 2	7040	14173(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	Fibroblast_growth_factor_2 modulates transforming_growth_factor_beta signaling in mouse embryonic fibroblasts and human ESCs -LRB- hESCs -RRB- to support hESC self-renewal .
21127043	0	transforming_growth_factor_beta	97,128	GATA6	0,5	transforming growth factor beta	GATA6	7040	2627	Gene	Gene	suppression|nmod|START_ENTITY promotes|nmod|suppression promotes|nsubj|END_ENTITY	GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming_growth_factor_beta / activin_receptor-like_kinase_5 signaling .
22293942	0	transforming_growth_factor_beta	125,156	IL-8	118,122	transforming growth factor beta	IL-8	7040	3576	Gene	Gene	expression|appos|START_ENTITY expression|appos|END_ENTITY	Association of glutathione_S-transferase 1-1 polymorphisms -LRB- A140D and E208K -RRB- with the expression of interleukin-8 -LRB- IL-8 -RRB- , transforming_growth_factor_beta -LRB- TGF-b -RRB- , and apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- in humans chronically exposed to arsenic in drinking water .
14612425	0	transforming_growth_factor_beta	41,72	PAK2	33,37	transforming growth factor beta	PAK2	7040	5062	Gene	Gene	independent|compound|START_ENTITY activation|nmod|independent activation|nmod|END_ENTITY	Cell-type-specific activation of PAK2 by transforming_growth_factor_beta independent of Smad2 and Smad3 .
16368780	0	transforming_growth_factor_beta	9,40	SMAD4	96,101	transforming growth factor beta	SMAD4	7040	4089	Gene	Gene	signalling|compound|START_ENTITY carcinogenesis|nsubj|signalling carcinogenesis|xcomp|due due|nmod|inactivation inactivation|compound|END_ENTITY	Impaired transforming_growth_factor_beta signalling in Barrett 's _ carcinogenesis due to frequent SMAD4 inactivation .
14612425	0	transforming_growth_factor_beta	41,72	Smad2	88,93	transforming growth factor beta	Smad2	7040	4087	Gene	Gene	independent|compound|START_ENTITY activation|nmod|independent activation|nmod|END_ENTITY	Cell-type-specific activation of PAK2 by transforming_growth_factor_beta independent of Smad2 and Smad3 .
11234879	0	transforming_growth_factor_beta	34,65	Smad4	10,15	transforming growth factor beta	Smad4	7040	4089	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Preserved Smad4 expression in the transforming_growth_factor_beta signaling pathway is a favorable prognostic factor in patients with advanced gastric_cancer .
9482899	0	transforming_growth_factor_beta	52,83	Smad4	21,26	transforming growth factor beta	Smad4	7040	4089	Gene	Gene	required|nmod|START_ENTITY shows|ccomp|required shows|nsubj|deletion deletion|nmod|END_ENTITY	Targeted deletion of Smad4 shows it is required for transforming_growth_factor_beta and activin signaling in colorectal_cancer cells .
17438144	0	transforming_growth_factor_beta	18,49	Smad7	0,5	transforming growth factor beta	Smad7	7040	4092	Gene	Gene	antagonizes|dobj|START_ENTITY antagonizes|nsubj|END_ENTITY	Smad7 antagonizes transforming_growth_factor_beta signaling in the nucleus by interfering with functional Smad-DNA complex formation .
21324108	0	transforming_growth_factor_beta	14,45	Sp1	159,162	transforming growth factor beta	Sp1	7040	6667	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|dep|involvement involvement|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
21324108	0	transforming_growth_factor_beta	204,235	Sp1	159,162	transforming growth factor beta	Sp1	7040	6667	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
21324108	0	transforming_growth_factor_beta	74,105	Sp1	159,162	transforming growth factor beta	Sp1	7040	6667	Gene	Gene	signalling|nmod|START_ENTITY Modulation|acl|signalling Modulation|dep|involvement involvement|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
16952379	0	transforming_growth_factor_beta	14,45	TGF-b1	47,53	transforming growth factor beta	TGF-b1	7040	7040	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of transforming_growth_factor_beta -LRB- TGF-b1 -RRB- by human preterm lung inflammatory cells .
11984735	0	transforming_growth_factor_beta	14,45	TGF-beta	47,55	transforming growth factor beta	TGF-beta	7040	7040	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of transforming_growth_factor_beta -LRB- TGF-beta -RRB- may contribute , in part , to the variations in histogenesis and the prevalence of peritoneal dissemination in human gastric_carcinoma .
12539688	0	transforming_growth_factor_beta	15,46	TGF-beta	47,55	transforming growth factor beta	TGF-beta	7040	7040	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of transforming_growth_factor_beta -LRB- TGF-beta -RRB- subtypes in oral_squamous_cell_carcinoma -RSB- .
14676202	0	transforming_growth_factor_beta	23,54	TGF-beta	56,64	transforming growth factor beta	TGF-beta	7040	7040	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Differential effect of transforming_growth_factor_beta -LRB- TGF-beta -RRB- on the genes encoding hyaluronan synthases and utilization of the p38 MAPK pathway in TGF-beta-induced hyaluronan_synthase_1 activation .
8389483	0	transforming_growth_factor_beta	21,52	TGF-beta	54,62	transforming growth factor beta	TGF-beta	7040	7040	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Growth inhibition by transforming_growth_factor_beta -LRB- TGF-beta -RRB- type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta_receptor_type_II cDNA .
8670764	0	transforming_growth_factor_beta	28,59	TGF-beta	61,69	transforming growth factor beta	TGF-beta	7040	7040	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	Production and secretion of transforming_growth_factor_beta -LRB- TGF-beta -RRB- by the human lacrimal gland .
2169765	0	transforming_growth_factor_beta	19,50	TGF_beta	52,60	transforming growth factor beta	TGF beta	7040	7040	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Protective role of transforming_growth_factor_beta -LRB- TGF_beta -RRB- in tumor-induced degradation of basement membranes .
8120044	0	transforming_growth_factor_beta	46,77	TGF_beta	79,87	transforming growth factor beta	TGF beta	7040	7040	Gene	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	Characterization and autoregulation of latent transforming_growth_factor_beta -LRB- TGF_beta -RRB- complexes in osteoblast-like cell lines .
8268968	0	transforming_growth_factor_beta	8,39	TGF_beta	41,49	transforming growth factor beta	TGF beta	7040	7040	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of transforming_growth_factor_beta -LRB- TGF_beta -RRB- in systemic autoimmunity .
8388229	0	transforming_growth_factor_beta	14,45	TGF_beta	47,55	transforming growth factor beta	TGF beta	7040	7040	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression of transforming_growth_factor_beta -LRB- TGF_beta -RRB- receptors and expression of TGF_beta_1 , TGF_beta_2 and TGF_beta 3 in human small_cell_lung_cancer_cell lines .
9330712	0	transforming_growth_factor_beta	15,46	TGF_beta	48,56	transforming growth factor beta	TGF beta	7040	7040	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of transforming_growth_factor_beta -LRB- TGF_beta -RRB- with proteinase_3 .
12707256	0	transforming_growth_factor_beta	61,92	TGFbeta	147,154	transforming growth factor beta	TGFbeta	7040	21803(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor leads|nsubj|expression leads|xcomp|paradoxical paradoxical|dobj|activation activation|nmod|END_ENTITY	Fibroblast-specific expression of a kinase-deficient type II transforming_growth_factor_beta -LRB- TGFbeta -RRB- receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic_mice .
12707256	0	transforming_growth_factor_beta	61,92	TGFbeta	94,101	transforming growth factor beta	TGFbeta	7040	21803(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Fibroblast-specific expression of a kinase-deficient type II transforming_growth_factor_beta -LRB- TGFbeta -RRB- receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic_mice .
16686283	0	transforming_growth_factor_beta	14,45	TGFbeta1	47,55	transforming growth factor beta	TGFbeta1	7040	7040	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Inhibition of transforming_growth_factor_beta -LRB- TGFbeta1 -RRB- expression and extracellular matrix secretion in human peritoneal mesothelial cells by pcDU6 vector-mediated TGFbeta1 shRNA and by pcDNA3 .1 -LRB- - -RRB- - mediated antisense TGFbeta1 RNA .
19498318	0	transforming_growth_factor_beta	141,172	adiponectin	16,27	transforming growth factor beta	adiponectin	7040	9370	Gene	Gene	levels|nmod|START_ENTITY levels|compound|END_ENTITY	The relation of adiponectin and tumor_necrosis_factor_alpha levels between endothelial_nitric_oxide_synthase , angiotensin-converting_enzyme , transforming_growth_factor_beta , and tumor_necrosis_factor_alpha gene polymorphism in adrenal_incidentalomas .
16868985	0	transforming_growth_factor_beta	163,194	allograft_inflammatory_factor_1	14,45	transforming growth factor beta	allograft inflammatory factor 1	7040	199	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of allograft_inflammatory_factor_1 in tissues from patients with systemic_sclerosis and in vitro differential expression of its isoforms in response to transforming_growth_factor_beta .
12177061	0	transforming_growth_factor_beta	91,122	apolipoprotein_B	61,77	transforming growth factor beta	apolipoprotein B	7040	338	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|regulation regulation|nmod|END_ENTITY	Differential , tissue-specific , transcriptional regulation of apolipoprotein_B secretion by transforming_growth_factor_beta .
11767002	0	transforming_growth_factor_beta	8,39	basic_fibroblast_growth_factor	97,127	transforming growth factor beta	basic fibroblast growth factor	7040	2247	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of transforming_growth_factor_beta in the growth inhibition of human breast_cancer cells by basic_fibroblast_growth_factor .
8226781	0	transforming_growth_factor_beta	16,47	betaglycan	64,74	transforming growth factor beta	betaglycan	7040	7049	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Localization of transforming_growth_factor_beta binding site in betaglycan .
9858615	0	transforming_growth_factor_beta	36,67	cdc25A	82,88	transforming growth factor beta	cdc25A	7040	993	Gene	Gene	repression|compound|START_ENTITY repression|nmod|END_ENTITY	E2F and histone deacetylase mediate transforming_growth_factor_beta repression of cdc25A during keratinocyte cell cycle arrest .
11046139	0	transforming_growth_factor_beta	105,136	cdk4	183,187	transforming growth factor beta	cdk4	7040	1019	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	p53 binds selectively to the 5 ' untranslated region of cdk4 , an RNA element necessary and sufficient for transforming_growth_factor_beta - and p53-mediated translational inhibition of cdk4 .
19821534	0	transforming_growth_factor_beta	68,99	connective_tissue_growth_factor	19,50	transforming growth factor beta	connective tissue growth factor	7040	1490	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Down-regulation of connective_tissue_growth_factor by inhibition of transforming_growth_factor_beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular_carcinoma .
24037310	0	transforming_growth_factor_beta	57,88	cysteine-rich_protein_61	21,45	transforming growth factor beta	cysteine-rich protein 61	7040	3491	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The up-regulation of cysteine-rich_protein_61 induced by transforming_growth_factor_beta enhances osteosarcoma cell migration .
11834172	0	transforming_growth_factor_beta	65,96	epidermal_growth_factor_receptor	31,63	transforming growth factor beta	epidermal growth factor receptor	7040	1956	Gene	Gene	oncogene|dep|START_ENTITY oncogene|compound|END_ENTITY	-LSB- Significance of expression of epidermal_growth_factor_receptor , transforming_growth_factor_beta , c-erbB-2 oncogene in myoepithelioma of salivary gland -RSB- .
2613750	0	transforming_growth_factor_beta	112,143	epidermal_growth_factor_receptor	71,103	transforming growth factor beta	epidermal growth factor receptor	7040	1956	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Modulation of transforming_growth_factor_alpha-dependent expression of epidermal_growth_factor_receptor gene by transforming_growth_factor_beta , triiodothyronine , and retinoic_acid .
17984934	0	transforming_growth_factor_beta	37,68	fibrillin-1	109,120	transforming growth factor beta	fibrillin-1	7040	2200	Gene	Gene	domain|amod|START_ENTITY domain|nmod|gene gene|amod|END_ENTITY	Novel non-synonymous mutation in the transforming_growth_factor_beta binding protein-like -LRB- TB -RRB- domain of the fibrillin-1 -LRB- FBN1 -RRB- gene in a Han Chinese family with Marfan_syndrome -LRB- MFS -RRB- .
11874241	0	transforming_growth_factor_beta	83,114	fibroblast_growth_factor_2	14,40	transforming growth factor beta	fibroblast growth factor 2	7040	2247	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|receptors receptors|amod|END_ENTITY	Regulation of fibroblast_growth_factor_2 and fibroblast growth factor receptors by transforming_growth_factor_beta in human osteoblastic MG-63 cells .
20193171	0	transforming_growth_factor_beta	36,67	interferon-gamma	12,28	transforming growth factor beta	interferon-gamma	7040	3458	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	-LSB- Effects of interferon-gamma on the transforming_growth_factor_beta / Smad pathway in keloid-derived fibroblasts -RSB- .
8100485	0	transforming_growth_factor_beta	61,92	interferon_gamma	21,37	transforming growth factor beta	interferon gamma	7040	3458	Gene	Gene	Interactions|nmod|START_ENTITY Interactions|nmod|END_ENTITY	Interactions between interferon_gamma and retinoic_acid with transforming_growth_factor_beta in the induction of immune recognition molecules .
8380285	0	transforming_growth_factor_beta	79,110	interleukin-2	29,42	transforming growth factor beta	interleukin-2	7040	3558	Gene	Gene	inhibition|compound|START_ENTITY END_ENTITY|nmod|inhibition	Effect of anti-CD3 / anti-CD28 / interleukin-2 stimulation of mononuclear cells on transforming_growth_factor_beta inhibition of lymphokine-activated killer cell generation .
2390123	0	transforming_growth_factor_beta	47,78	interleukin-4	14,27	transforming growth factor beta	interleukin-4	7040	3565	Gene	Gene	levels|nmod|START_ENTITY levels|nmod|levels levels|compound|END_ENTITY	Low levels of interleukin-4 and high levels of transforming_growth_factor_beta in rheumatoid_synovitis .
22293942	0	transforming_growth_factor_beta	125,156	interleukin-8	103,116	transforming growth factor beta	interleukin-8	7040	3576	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Association of glutathione_S-transferase 1-1 polymorphisms -LRB- A140D and E208K -RRB- with the expression of interleukin-8 -LRB- IL-8 -RRB- , transforming_growth_factor_beta -LRB- TGF-b -RRB- , and apoptotic_protease-activating_factor_1 -LRB- Apaf-1 -RRB- in humans chronically exposed to arsenic in drinking water .
7749575	0	transforming_growth_factor_beta	68,99	interleukin_6	40,53	transforming growth factor beta	interleukin 6	7040	3569	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|production production|amod|END_ENTITY	Regulation of monocyte and keratinocyte interleukin_6 production by transforming_growth_factor_beta .
10623468	0	transforming_growth_factor_beta	40,71	keratin_15	15,25	transforming growth factor beta	keratin 15	7040	3866	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Suppression of keratin_15 expression by transforming_growth_factor_beta in vitro and by cutaneous injury in vivo .
9846835	0	transforming_growth_factor_beta	90,121	monocyte_chemoattractant_protein-1	24,58	transforming growth factor beta	monocyte chemoattractant protein-1	7040	6347	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|nmod|END_ENTITY	Astrocyte expression of monocyte_chemoattractant_protein-1 is differentially regulated by transforming_growth_factor_beta .
12217602	0	transforming_growth_factor_beta	130,161	p21	91,94	transforming growth factor beta	p21	7040	1026	Gene	Gene	effect|nmod|START_ENTITY down-regulation|dep|effect down-regulation|amod|END_ENTITY	Infection of HepG2 cells with recombinant adenovirus encoding the HCV core protein induces p21 -LRB- WAF1 -RRB- down-regulation -- effect of transforming_growth_factor_beta .
16284627	0	transforming_growth_factor_beta	63,94	p21	30,33	transforming growth factor beta	p21	7040	1026	Gene	Gene	pathway|compound|START_ENTITY mediated|nmod|pathway mediated|nsubjpass|activation activation|nmod|END_ENTITY	Transcriptional activation of p21 by Tranilast is mediated via transforming_growth_factor_beta signal pathway .
9819384	0	transforming_growth_factor_beta	94,125	p21	0,3	transforming growth factor beta	p21	7040	1026	Gene	Gene	element|amod|START_ENTITY upregulated|nmod|element upregulated|nsubjpass|END_ENTITY	p21 -LRB- WAF1/CIP1 -RRB- is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming_growth_factor_beta - and Sp1-responsive element : involvement of the small GTPase rhoA .
10920185	0	transforming_growth_factor_beta	72,103	p21CIP1	41,48	transforming growth factor beta	p21CIP1	7040	1026	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming_growth_factor_beta - induced cell-cycle arrest .
9870872	0	transforming_growth_factor_beta	162,193	parathyroid_hormone-related_protein	86,121	transforming growth factor beta	parathyroid hormone-related protein	7040	5744	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|isoform isoform|amod|END_ENTITY	Parathyroid_hormone-related_proteins is abundant in osteoarthritic cartilage , and the parathyroid_hormone-related_protein 1-173 isoform is selectively induced by transforming_growth_factor_beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate .
9330712	0	transforming_growth_factor_beta	15,46	proteinase_3	63,75	transforming growth factor beta	proteinase 3	7040	5657	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction of transforming_growth_factor_beta -LRB- TGF_beta -RRB- with proteinase_3 .
18471442	0	transforming_growth_factor_beta	104,135	tissue_inhibitor_of_metalloproteinases-3	49,89	transforming growth factor beta	tissue inhibitor of metalloproteinases-3	7040	7078	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	Smad signaling pathway is a pivotal component of tissue_inhibitor_of_metalloproteinases-3 regulation by transforming_growth_factor_beta in human chondrocytes .
21324108	0	transforming_growth_factor_beta	14,45	transforming_growth_factor_beta	204,235	transforming growth factor beta	transforming growth factor beta	7040	7040	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|dep|involvement involvement|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
21324108	0	transforming_growth_factor_beta	204,235	transforming_growth_factor_beta	14,45	transforming growth factor beta	transforming growth factor beta	7040	7040	Gene	Gene	involvement|nmod|START_ENTITY Modulation|dep|involvement Modulation|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
21324108	0	transforming_growth_factor_beta	204,235	transforming_growth_factor_beta	74,105	transforming growth factor beta	transforming growth factor beta	7040	7040	Gene	Gene	involvement|nmod|START_ENTITY Modulation|dep|involvement Modulation|acl|signalling signalling|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
21324108	0	transforming_growth_factor_beta	74,105	transforming_growth_factor_beta	204,235	transforming growth factor beta	transforming growth factor beta	7040	7040	Gene	Gene	signalling|nmod|START_ENTITY Modulation|acl|signalling Modulation|dep|involvement involvement|nmod|END_ENTITY	Modulation of transforming_growth_factor_beta signalling pathway genes by transforming_growth_factor_beta in human osteoarthritic chondrocytes : involvement of Sp1 in both early and late response cells to transforming_growth_factor_beta .
10843986	0	transforming_growth_factor_beta	46,77	transforming_growth_factor_beta_1	82,115	transforming growth factor beta	transforming growth factor beta 1	7040	7040	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Requirement of Ras/MAPK pathway activation by transforming_growth_factor_beta for transforming_growth_factor_beta_1 production in a Smad-dependent pathway .
11243465	0	transforming_growth_factor_beta	14,45	tumor_necrosis_factor_alpha	96,123	transforming growth factor beta	tumor necrosis factor alpha	7040	7124	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|END_ENTITY	Inhibition of transforming_growth_factor_beta signaling in MCF-7 cells results in resistance to tumor_necrosis_factor_alpha : a role for Bcl-2 .
9665972	0	transforming_growth_factor_beta	102,133	tumor_necrosis_factor_alpha	46,73	transforming growth factor beta	tumor necrosis factor alpha	7040	7124	Gene	Gene	bovis|nmod|START_ENTITY bovis|dobj|secretion secretion|compound|END_ENTITY	Inhibition of Mycobacterium bovis BCG-induced tumor_necrosis_factor_alpha secretion in human cells by transforming_growth_factor_beta .
8818797	0	transforming_growth_factor_beta-1	99,132	IGFBP-3	144,151	transforming growth factor beta-1	IGFBP-3	7040	3486	Gene	Gene	production|amod|START_ENTITY production|compound|END_ENTITY	Cultured porcine myogenic cells produce insulin-like_growth_factor_binding_protein-3 -LRB- IGFBP-3 -RRB- and transforming_growth_factor_beta-1 stimulates IGFBP-3 production .
17651487	0	transforming_growth_factor_beta-1	20,53	TGF-beta-1	55,65	transforming growth factor beta-1	TGF-beta-1	7040	7040	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	` Correction : ' Serum transforming_growth_factor_beta-1 -LRB- TGF-beta-1 -RRB- levels in diabetic patients are not associated with pre-existent coronary_artery_disease .
7895806	0	transforming_growth_factor_beta-1	46,79	TGF-beta_1	81,91	transforming growth factor beta-1	TGF-beta 1	59086(Tax:10116)	59086(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Cytokines in cerebral_ischemia : expression of transforming_growth_factor_beta-1 -LRB- TGF-beta_1 -RRB- mRNA in the postischemic adult rat hippocampus .
22503347	0	transforming_growth_factor_beta-1	37,70	TGFb1	72,77	transforming growth factor beta-1	TGFb1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Promoter region polymorphisms in the transforming_growth_factor_beta-1 -LRB- TGFb1 -RRB- gene and serum TGFb1 concentration in preeclamptic and control Iranian women .
15177960	0	transforming_growth_factor_beta-induced	75,114	BIGH3	116,121	transforming growth factor beta-induced	BIGH3	7045	7045	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphic corneal_amyloidosis : a disorder due to a novel mutation in the transforming_growth_factor_beta-induced -LRB- BIGH3 -RRB- gene .
15885785	0	transforming_growth_factor_beta-induced	102,141	TGFBI	143,148	transforming growth factor beta-induced	TGFBI	7045	7045	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A unique corneal_dystrophy of Bowman 's layer and stroma associated with the Gly623Asp mutation in the transforming_growth_factor_beta-induced -LRB- TGFBI -RRB- gene .
11855979	0	transforming_growth_factor_beta1	42,74	ALK5	104,108	transforming growth factor beta1	ALK5	7040	7046	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Identification of novel inhibitors of the transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- type 1 receptor -LRB- ALK5 -RRB- .
16157589	0	transforming_growth_factor_beta1	95,127	JNK1	75,79	transforming growth factor beta1	JNK1	7040	5599	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- inhibits c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation by transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 -LRB- TAK1 -RRB- .
11073979	0	transforming_growth_factor_beta1	28,60	Runx2	0,5	transforming growth factor beta1	Runx2	21803(Tax:10090)	12393(Tax:10090)	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Runx2 is a common target of transforming_growth_factor_beta1 and bone_morphogenetic_protein_2 , and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12 .
15481772	0	transforming_growth_factor_beta1	33,65	TGF-beta1	67,76	transforming growth factor beta1	TGF-beta1	7040	7040	Gene	Gene	concentrations|nmod|START_ENTITY concentrations|appos|END_ENTITY	Reduced plasma concentrations of transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- in obese women .
17891595	0	transforming_growth_factor_beta1	14,46	TGF-beta1	48,57	transforming growth factor beta1	TGF-beta1	100008645(Tax:9986)	100008645(Tax:9986)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- on the regenerate bone in distraction osteogenesis .
11675471	0	transforming_growth_factor_beta1	18,50	TGFbeta1	52,60	transforming growth factor beta1	TGFbeta1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Quantification of transforming_growth_factor_beta1 -LRB- TGFbeta1 -RRB- mRNA expression in mouse preimplantation embryos and determination of TGFbeta receptor -LRB- type I and type II -RRB- expression in mouse embryos and reproductive tract .
15015581	0	transforming_growth_factor_beta1	90,122	TGFbeta1	124,132	transforming growth factor beta1	TGFbeta1	7040	7040	Gene	Gene	signal|amod|START_ENTITY signal|appos|END_ENTITY	The inhibitory effects of gossypol on human prostate_cancer cells-PC3 are associated with transforming_growth_factor_beta1 -LRB- TGFbeta1 -RRB- signal transduction pathway .
19383262	0	transforming_growth_factor_beta1	10,42	Tgfb1	77,82	transforming growth factor beta1	Tgfb1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	replacement|compound|START_ENTITY replacement|nmod|END_ENTITY	Exogenous transforming_growth_factor_beta1 replacement and fertility in male Tgfb1 null mutant mice .
10926856	0	transforming_growth_factor_beta1	35,67	Thrombospondin_1	0,16	transforming growth factor beta1	Thrombospondin 1	59086(Tax:10116)	445442(Tax:10116)	Gene	Gene	activate|dobj|START_ENTITY activate|nsubj|END_ENTITY	Thrombospondin_1 does not activate transforming_growth_factor_beta1 in a chemically defined system or in smooth-muscle-cell cultures .
16157589	0	transforming_growth_factor_beta1	95,127	c-Jun_N-terminal_kinase_1	48,73	transforming growth factor beta1	c-Jun N-terminal kinase 1	7040	5599	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	X-linked_inhibitor_of_apoptosis -LRB- XIAP -RRB- inhibits c-Jun_N-terminal_kinase_1 -LRB- JNK1 -RRB- activation by transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 -LRB- TAK1 -RRB- .
17920062	0	transforming_growth_factor_beta1	16,48	cholesterol_7alpha-hydroxylase	88,118	transforming growth factor beta1	cholesterol 7alpha-hydroxylase	7040	1581	Gene	Gene	role|nmod|START_ENTITY role|nmod|gene gene|amod|END_ENTITY	A novel role of transforming_growth_factor_beta1 in transcriptional repression of human cholesterol_7alpha-hydroxylase gene .
9030534	0	transforming_growth_factor_beta1	171,203	epidermal_growth_factor	114,137	transforming growth factor beta1	epidermal growth factor	21803(Tax:10090)	13645(Tax:10090)	Gene	Gene	hormone|dep|START_ENTITY hormone|dep|END_ENTITY	Hyaluronan synthesis by mouse cumulus cells is regulated by interactions between follicle-stimulating hormone -LRB- or epidermal_growth_factor -RRB- and a soluble oocyte factor -LRB- or transforming_growth_factor_beta1 -RRB- .
16900348	0	transforming_growth_factor_beta1	39,71	galectin-1	14,24	transforming growth factor beta1	galectin-1	7040	3956	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of galectin-1 expression by transforming_growth_factor_beta1 in metastatic mammary_adenocarcinoma cells : implications for tumor-immune escape .
9603256	0	transforming_growth_factor_beta1	8,40	granulocyte-macrophage_colony-stimulating_factor	52,100	transforming growth factor beta1	granulocyte-macrophage colony-stimulating factor	21803(Tax:10090)	12981(Tax:10090)	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|production production|amod|END_ENTITY	Seminal transforming_growth_factor_beta1 stimulates granulocyte-macrophage_colony-stimulating_factor production and inflammatory cell recruitment in the murine uterus .
25048558	0	transforming_growth_factor_beta1	117,149	interleukin-1beta	70,87	transforming growth factor beta1	interleukin-1beta	7040	3553	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Topical ALA-PDT modifies neutrophils ' chemiluminescence , lymphocytes ' interleukin-1beta secretion and serum level of transforming_growth_factor_beta1 in patients with nonmelanoma skin_malignancies A clinical study .
12781036	0	transforming_growth_factor_beta1	15,47	plasminogen_activator_inhibitor-1	56,89	transforming growth factor beta1	plasminogen activator inhibitor-1	7040	5054	Gene	Gene	START_ENTITY|acl|induced induced|xcomp|END_ENTITY	Rhein inhibits transforming_growth_factor_beta1 induced plasminogen_activator_inhibitor-1 in endothelial cells .
10075006	0	transforming_growth_factor_beta1	41,73	prostate-specific_antigen	161,186	transforming growth factor beta1	prostate-specific antigen	7040	354	Gene	Gene	upregulation|nmod|START_ENTITY associated|nsubjpass|upregulation associated|nmod|END_ENTITY	Early castration-induced upregulation of transforming_growth_factor_beta1 and its receptors is associated with tumor cell apoptosis and a major decline in serum prostate-specific_antigen in prostate_cancer patients .
9815590	0	transforming_growth_factor_beta1	55,87	prostate-specific_antigen	112,137	transforming growth factor beta1	prostate-specific antigen	7040	354	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of 13-cis-retinoic_acid and alpha-interferon on transforming_growth_factor_beta1 in patients with rising prostate-specific_antigen .
10194419	0	transforming_growth_factor_beta1	13,45	thrombospondin-1	138,154	transforming growth factor beta1	thrombospondin-1	7040	7057	Gene	Gene	TGF-beta1|amod|START_ENTITY Influence|nmod|TGF-beta1 thyroid|nsubj|Influence thyroid|nmod|synthesis synthesis|amod|END_ENTITY	Influence of transforming_growth_factor_beta1 -LRB- TGF-beta1 -RRB- on the behaviour of porcine thyroid epithelial cells in primary culture through thrombospondin-1 synthesis .
16733556	1	transforming_growth_factor_beta1	145,177	thrombospondin-1	200,216	transforming growth factor beta1	thrombospondin-1	7040	7057	Gene	Gene	involvement|nmod|START_ENTITY involvement|nmod|END_ENTITY	The involvement of transforming_growth_factor_beta1 and its activation by thrombospondin-1 .
9215644	0	transforming_growth_factor_beta3	126,158	alpha-actin	28,39	transforming growth factor beta3	alpha-actin	396438(Tax:9031)	423787(Tax:9031)	Gene	Gene	role|nmod|START_ENTITY Expression|dep|role Expression|nmod|END_ENTITY	Expression of smooth muscle alpha-actin in mesenchymal cells during formation of avian endocardial cushion tissue : a role for transforming_growth_factor_beta3 .
9111519	0	transforming_growth_factor_beta_1	67,100	Basic_fibroblast_growth_factor	0,30	transforming growth factor beta 1	Basic fibroblast growth factor	7040	2247	Gene	Gene	release|nmod|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor stimulates the release of preformed transforming_growth_factor_beta_1 from human proximal tubular cells in the absence of de novo gene transcription or mRNA translation .
1404666	0	transforming_growth_factor_beta_1	86,119	C-jun	18,23	transforming growth factor beta 1	C-jun	7040	3725	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|mRNA mRNA|amod|END_ENTITY	The expression of C-jun and junB mRNA in renal_cell_cancer and in vitro regulation by transforming_growth_factor_beta_1 and tumor_necrosis_factor_alpha 1 .
22106837	0	transforming_growth_factor_beta_1	20,53	TGF-b1	55,61	transforming growth factor beta 1	TGF-b1	7040	7040	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Prognostic value of transforming_growth_factor_beta_1 -LSB- TGF-b1 -RSB- and matrix_metalloproteinase_9 -LSB- MMP-9 -RSB- in oral_squamous_cell_carcinoma .
25266958	0	transforming_growth_factor_beta_1	29,62	TGF-b1	64,70	transforming growth factor beta 1	TGF-b1	7040	7040	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Placental gene expression of transforming_growth_factor_beta_1 -LRB- TGF-b1 -RRB- in small for gestational age newborns .
20517890	0	transforming_growth_factor_beta_1	12,45	TGF-beta1	47,56	transforming growth factor beta 1	TGF-beta1	7040	7040	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of transforming_growth_factor_beta_1 -LRB- TGF-beta1 -RRB- gene polymorphisms in Turkish patients with scleroderma .
1525582	0	transforming_growth_factor_beta_1	15,48	TGF-beta_1	50,60	transforming growth factor beta 1	TGF-beta 1	443417(Tax:9940)	443417(Tax:9940)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Iodide induces transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- mRNA in sheep thyroid cells .
2358774	0	transforming_growth_factor_beta_1	23,56	TGF-beta_1	58,68	transforming growth factor beta 1	TGF-beta 1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transactivation of the transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- gene by human_T_lymphotropic_virus_type_1 tax : a potential mechanism for the increased production of TGF-beta_1 in adult_T_cell_leukemia .
9169066	0	transforming_growth_factor_beta_1	30,63	TGF-beta_1	65,75	transforming growth factor beta 1	TGF-beta 1	21803(Tax:10090)	21803(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of liver-associated transforming_growth_factor_beta_1 -LRB- TGF-beta_1 -RRB- mRNA expression by carbon_tetrachloride leads to the inhibition of T helper 2 cell-associated lymphokines .
18284942	0	transforming_growth_factor_beta_1	65,98	TGFB1	105,110	transforming growth factor beta 1	TGFB1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Large-scale analysis of association between polymorphisms in the transforming_growth_factor_beta_1 gene -LRB- TGFB1 -RRB- and osteoporosis : the GENOMOS study .
23597094	0	transforming_growth_factor_beta_1	57,90	TGFb1	92,97	transforming growth factor beta 1	TGFb1	7040	7040	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Gene-environment interaction between body mass index and transforming_growth_factor_beta_1 -LRB- TGFb1 -RRB- gene in knee and hip_osteoarthritis .
2161812	0	transforming_growth_factor_beta_1	34,67	c-myc	14,19	transforming growth factor beta 1	c-myc	7040	4609	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|nmod|expression expression|amod|END_ENTITY	Modulation of c-myc expression by transforming_growth_factor_beta_1 in human hepatoma cell lines .
12697724	0	transforming_growth_factor_beta_1	123,156	calcitonin	160,170	transforming growth factor beta 1	calcitonin	59086(Tax:10116)	24241(Tax:10116)	Gene	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Antiproliferative action of calcitonin on lactotrophs of the rat anterior pituitary gland : evidence for the involvement of transforming_growth_factor_beta_1 in calcitonin action .
7986746	0	transforming_growth_factor_beta_1	68,101	epidermal_growth_factor_receptor	13,45	transforming growth factor beta 1	epidermal growth factor receptor	59086(Tax:10116)	24329(Tax:10116)	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Induction of epidermal_growth_factor_receptor gene transcription by transforming_growth_factor_beta_1 : association with loss of protein binding to a negative regulatory element .
9462692	0	transforming_growth_factor_beta_1	13,46	insulin-like_growth_factor-1	50,78	transforming growth factor beta 1	insulin-like growth factor-1	7040	3479	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of transforming_growth_factor_beta_1 by insulin-like_growth_factor-1 in dermal fibroblasts .
12733346	0	transforming_growth_factor_beta_1	12,45	integrin_beta_3	67,82	transforming growth factor beta 1	integrin beta 3	7040	3690	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of transforming_growth_factor_beta_1 on the expression of integrin_beta_3 and the activity of focal_adhesion_kinase on human vascular endothelial cell -RSB- .
15300203	0	transforming_growth_factor_beta_1	20,53	p21	122,125	transforming growth factor beta 1	p21	21803(Tax:10090)	12575(Tax:10090)	Gene	Gene	exposure|nmod|START_ENTITY confers|nsubj|exposure confers|nmod|downregulation downregulation|nmod|END_ENTITY	Chronic exposure of transforming_growth_factor_beta_1 confers a more aggressive tumor phenotype through downregulation of p21 -LRB- WAF1/CIP1 -RRB- in conditionally immortalized pancreatic epithelial cells .
8641969	0	transforming_growth_factor_beta_1	29,62	p21	111,114	transforming growth factor beta 1	p21	7040	1026	Gene	Gene	growth|nmod|START_ENTITY Inhibition|nmod|growth associated|nsubjpass|Inhibition associated|nmod|induction induction|nmod|END_ENTITY	Inhibition of cell growth by transforming_growth_factor_beta_1 is associated with p53-independent induction of p21 in gastric_carcinoma cells .
8590973	0	transforming_growth_factor_beta_1	33,66	phospholipase_A2	108,124	transforming growth factor beta 1	phospholipase A2	7040	151056	Gene	Gene	inhibition|amod|START_ENTITY inhibition|nmod|END_ENTITY	Prostaglandin_E2 requirement for transforming_growth_factor_beta_1 inhibition of elicited macrophage 14 kDa phospholipase_A2 release .
7492690	0	transforming_growth_factor_beta_1	75,108	placental_lactogen-II	40,61	transforming growth factor beta 1	placental lactogen-II	21803(Tax:10090)	18776(Tax:10090)	Gene	Gene	secretion|nmod|START_ENTITY secretion|compound|END_ENTITY	Posttranscriptional inhibition of mouse placental_lactogen-II secretion by transforming_growth_factor_beta_1 : synergistic effects with epidermal_growth_factor and interleukin-6 .
10770042	0	transforming_growth_factor_beta_1	71,104	prolactin	108,117	transforming growth factor beta 1	prolactin	7040	5617	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|secretion secretion|compound|END_ENTITY	In vitro differentiation of human endometrial stromal cells : effect of transforming_growth_factor_beta_1 on prolactin secretion .
7790386	0	transforming_growth_factor_beta_1	79,112	protein_kinase_C_alpha	8,30	transforming growth factor beta 1	protein kinase C alpha	7040	5578	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of protein_kinase_C_alpha in the induction of carcinoembryonic_antigen by transforming_growth_factor_beta_1 .
23131192	0	transforming_growth_factor_beta_1	93,126	thrombin	57,65	transforming growth factor beta 1	thrombin	282089(Tax:9913)	280685(Tax:9913)	Gene	Gene	release|nmod|START_ENTITY END_ENTITY|nmod|release	Evaluation of the effect of calcium_gluconate and bovine thrombin on the temporal release of transforming_growth_factor_beta_1 and platelet-derived growth factor isoform BB from feline platelet concentrates .
10843986	0	transforming_growth_factor_beta_1	82,115	transforming_growth_factor_beta	46,77	transforming growth factor beta 1	transforming growth factor beta	7040	7040	Gene	Gene	production|amod|START_ENTITY END_ENTITY|nmod|production	Requirement of Ras/MAPK pathway activation by transforming_growth_factor_beta for transforming_growth_factor_beta_1 production in a Smad-dependent pathway .
8416744	0	transforming_growth_factor_beta_1	43,76	transforming_growth_factor_beta_1	88,121	transforming growth factor beta 1	transforming growth factor beta 1	7040	7040	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Immunoelectron microscopic localization of transforming_growth_factor_beta_1 and latent transforming_growth_factor_beta_1 binding protein in human gastrointestinal_carcinomas : qualitative difference between cancer cells and stromal cells .
8416744	0	transforming_growth_factor_beta_1	88,121	transforming_growth_factor_beta_1	43,76	transforming growth factor beta 1	transforming growth factor beta 1	7040	7040	Gene	Gene	protein|amod|START_ENTITY protein|amod|END_ENTITY	Immunoelectron microscopic localization of transforming_growth_factor_beta_1 and latent transforming_growth_factor_beta_1 binding protein in human gastrointestinal_carcinomas : qualitative difference between cancer cells and stromal cells .
11983447	0	transforming_growth_factor_beta_1	89,122	urokinase-type_plasminogen_activator	14,50	transforming growth factor beta 1	urokinase-type plasminogen activator	21803(Tax:10090)	18792(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of urokinase-type_plasminogen_activator delays expression of c-jun , activated transforming_growth_factor_beta_1 , and matrix_metalloproteinase_2 during post-hepatectomy liver_regeneration in mice .
24302499	0	transforming_growth_factor_beta_induced	97,136	TGFBI	138,143	transforming growth factor beta induced	TGFBI	7045	7045	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Comparison of two phenotypically distinct lattice corneal_dystrophies caused by mutations in the transforming_growth_factor_beta_induced -LRB- TGFBI -RRB- gene .
16341765	0	transforming_growth_factor_beta_receptor_1	39,81	TGFBR1	83,89	transforming growth factor beta receptor 1	TGFBR1	396665(Tax:9823)	396665(Tax:9823)	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Structure and polymorphism analysis of transforming_growth_factor_beta_receptor_1 -LRB- TGFBR1 -RRB- in pigs .
24037531	0	transforming_growth_factor_beta_receptor_II	53,96	Androgen_receptor	0,17	transforming growth factor beta receptor II	Androgen receptor	7048	367	Gene	Gene	expression|amod|START_ENTITY downregulates|dobj|expression downregulates|nsubj|END_ENTITY	Androgen_receptor and microRNA-21 axis downregulates transforming_growth_factor_beta_receptor_II -LRB- TGFBR2 -RRB- expression in prostate_cancer .
24037531	0	transforming_growth_factor_beta_receptor_II	53,96	TGFBR2	98,104	transforming growth factor beta receptor II	TGFBR2	7048	7048	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Androgen_receptor and microRNA-21 axis downregulates transforming_growth_factor_beta_receptor_II -LRB- TGFBR2 -RRB- expression in prostate_cancer .
17566598	0	transforming_growth_factor_beta_type_II_receptor	24,72	TGFBR2	74,80	transforming growth factor beta type II receptor	TGFBR2	7048	7048	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Defective expression of transforming_growth_factor_beta_type_II_receptor -LRB- TGFBR2 -RRB- in the large cell variant of non-small_cell_lung_carcinoma .
16950575	0	transforming_growth_factor_beta_type_I_receptor	56,103	TGFBR1	105,111	transforming growth factor beta type I receptor	TGFBR1	396665(Tax:9823)	396665(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Isolation and molecular characterization of the porcine transforming_growth_factor_beta_type_I_receptor -LRB- TGFBR1 -RRB- gene .
22292700	0	transforming_growth_factor_beta_type_I_receptor	27,74	TGFBR1	76,82	transforming growth factor beta type I receptor	TGFBR1	396665(Tax:9823)	396665(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association of the porcine transforming_growth_factor_beta_type_I_receptor -LRB- TGFBR1 -RRB- gene with growth and carcass traits .
20924204	0	transgelin	21,31	SM22a	14,19	transgelin	SM22a	25123(Tax:10116)	25123(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of SM22a -LRB- transgelin -RRB- in glomerular and interstitial renal_injury .
22205114	0	transgelin	45,55	SM22a	38,43	transgelin	SM22a	6876	6876	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Quantitative histological analysis of SM22a -LRB- transgelin -RRB- in an adriamycin-induced focal_segmental_glomerulosclerosis model .
9170110	0	transglutaminase	22,38	cytostatic_factor	71,88	transglutaminase	cytostatic factor	7051	1437	Gene	Gene	START_ENTITY|nmod|development development|nmod|END_ENTITY	Role of amphibian egg transglutaminase in the development of secondary cytostatic_factor in vitro .
7765354	0	transglutaminase	74,90	interleukin-6	19,32	transglutaminase	interleukin-6	100379228(Tax:10141)	106027696	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Increase caused by interleukin-6 in promoter activity of guinea_pig liver transglutaminase gene .
21840417	0	transglutaminase-2	23,41	c-Jun_N-terminal_kinase	50,73	transglutaminase-2	c-Jun N-terminal kinase	7052	5599	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Novel participation of transglutaminase-2 through c-Jun_N-terminal_kinase activation in sphingosylphosphorylcholine-induced keratin reorganization of PANC-1 cells .
12162878	0	transglutaminase_2	18,36	IFN-gamma	0,9	transglutaminase 2	IFN-gamma	56083(Tax:10116)	25712(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IFN-gamma induces transglutaminase_2 expression in rat small intestinal cells .
19208340	0	transglutaminase_2	8,26	Sp1	99,102	transglutaminase 2	Sp1	21817(Tax:10090)	20683(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of transglutaminase_2 in liver_injury via cross-linking and silencing of transcription factor Sp1 .
20395409	0	transglutaminase_2	49,67	TG2	69,72	transglutaminase 2	TG2	7052	7052	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	A profiling platform for the characterization of transglutaminase_2 -LRB- TG2 -RRB- inhibitors .
12386092	0	transglutaminase_2	23,41	TGF-beta	91,99	transglutaminase 2	TGF-beta	7052	7040	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Enhanced expression of transglutaminase_2 in anterior_polar_cataracts and its induction by TGF-beta in vitro .
18353867	0	transglutaminase_2	31,49	TGFbeta	0,7	transglutaminase 2	TGFbeta	21817(Tax:10090)	21803(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY mediates|dobj|activation mediates|nsubj|END_ENTITY	TGFbeta mediates activation of transglutaminase_2 in response to oxidative stress that leads to protein_aggregation .
18174247	0	transglutaminase_2	4,22	TGM2	29,33	transglutaminase 2	TGM2	7052	7052	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The transglutaminase_2 gene -LRB- TGM2 -RRB- , a potential molecular marker for chemotherapeutic drug sensitivity , is epigenetically silenced in breast_cancer .
18405667	0	transglutaminase_2	14,32	beta-catenin	43,55	transglutaminase 2	beta-catenin	7052	1499	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|END_ENTITY	Extracellular transglutaminase_2 activates beta-catenin signaling in calcifying vascular smooth muscle cells .
15069073	0	transglutaminase_2	73,91	insulin-like_growth_factor-binding_protein-3	98,142	transglutaminase 2	insulin-like growth factor-binding protein-3	7052	3486	Gene	Gene	START_ENTITY|nmod|kinase kinase|amod|END_ENTITY	Tissue_transglutaminase has intrinsic kinase activity : identification of transglutaminase_2 as an insulin-like_growth_factor-binding_protein-3 kinase .
21908620	0	transglutaminase_2	28,46	thioredoxin	50,61	transglutaminase 2	thioredoxin	7052	7295	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of extracellular transglutaminase_2 by thioredoxin .
21908620	0	transglutaminase_2	28,46	thioredoxin	50,61	transglutaminase 2	thioredoxin	7052	7295	Gene	Gene	Activation|nmod|START_ENTITY Activation|nmod|END_ENTITY	Activation of extracellular transglutaminase_2 by thioredoxin .
22307675	0	transglutaminase_2	90,108	transglutaminases_1_and_4	49,74	transglutaminase 2	transglutaminases 1 and 4	56083(Tax:10116)	60335;64679	Gene	Gene	express|nmod|START_ENTITY express|dobj|END_ENTITY	Vena cava and aortic smooth muscle cells express transglutaminases_1_and_4 in addition to transglutaminase_2 .
15084592	0	transglutaminase_3	21,39	GMP	56,59	transglutaminase 3	GMP	7053	22978	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Crystal structure of transglutaminase_3 in complex with GMP : structural basis for nucleotide specificity .
11350930	0	transglutaminase_II	8,27	RhoA-associated_kinase-2	67,91	transglutaminase II	RhoA-associated kinase-2	7051	9475	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of transglutaminase_II in retinoic_acid-induced activation of RhoA-associated_kinase-2 .
22307675	0	transglutaminases_1_and_4	49,74	transglutaminase_2	90,108	transglutaminases 1 and 4	transglutaminase 2	60335;64679	56083(Tax:10116)	Gene	Gene	express|dobj|START_ENTITY express|nmod|END_ENTITY	Vena cava and aortic smooth muscle cells express transglutaminases_1_and_4 in addition to transglutaminase_2 .
11042129	0	transient_receptor_potential_4	36,66	TRP4	68,72	transient receptor potential 4	TRP4	7223	7223	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and expression of the human transient_receptor_potential_4 -LRB- TRP4 -RRB- gene : localization and functional expression of human TRP4 and TRP3 .
20056530	0	transient_receptor_potential_A1	23,54	TRPA1	56,61	transient receptor potential A1	TRPA1	8989	8989	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	The involvement of the transient_receptor_potential_A1 -LRB- TRPA1 -RRB- in the maintenance of mechanical and cold_hyperalgesia in persistent inflammation .
24884675	0	transient_receptor_potential_A1	113,144	TRPA1	146,151	transient receptor potential A1	TRPA1	8989	8989	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery , optimization , and biological evaluation of 5 - -LRB- 2 - -LRB- trifluoromethyl -RRB- phenyl -RRB- indazoles as a novel class of transient_receptor_potential_A1 -LRB- TRPA1 -RRB- antagonists .
20884333	0	transient_receptor_potential_A1	71,102	Transient_receptor_potential_V1	0,31	transient receptor potential A1	Transient receptor potential V1	100751384	100771135	Gene	Gene	activation|nmod|START_ENTITY regulates|dobj|activation regulates|nsubj|END_ENTITY	Transient_receptor_potential_V1 regulates activation and modulation of transient_receptor_potential_A1 by Ca2 + .
23541125	0	transient_receptor_potential_ankyrin-1	14,52	TRPA1	54,59	transient receptor potential ankyrin-1	TRPA1	8989	8989	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of transient_receptor_potential_ankyrin-1 -LRB- TRPA1 -RRB- in lung cells by wood_smoke particulate material .
18086308	0	transient_receptor_potential_ankyrin_1	72,110	TRPA1	112,117	transient receptor potential ankyrin 1	TRPA1	8989	8989	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Species-specific pharmacology of Trichloro -LRB- sulfanyl -RRB- ethyl_benzamides as transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- antagonists .
22641084	0	transient_receptor_potential_ankyrin_1	51,89	TRPA1	91,96	transient receptor potential ankyrin 1	TRPA1	277328(Tax:10090)	277328(Tax:10090)	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	H -LRB- 2 -RRB- S functions as a nociceptive messenger through transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- activation .
22721614	0	transient_receptor_potential_ankyrin_1	12,50	TRPA1	52,57	transient receptor potential ankyrin 1	TRPA1	312896(Tax:10116)	312896(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	The role of transient_receptor_potential_ankyrin_1 -LRB- TRPA1 -RRB- receptor activation in hydrogen-sulphide-induced CGRP-release and vasodilation .
22843691	0	transient_receptor_potential_ankyrin_repeat_1	48,93	Hypoxia-inducible_factor-1a	0,27	transient receptor potential ankyrin repeat 1	Hypoxia-inducible factor-1a	8989	3091	Gene	Gene	switches|nmod|START_ENTITY switches|nsubj|END_ENTITY	Hypoxia-inducible_factor-1a -LRB- HIF1a -RRB- switches on transient_receptor_potential_ankyrin_repeat_1 -LRB- TRPA1 -RRB- gene expression via a hypoxia response element-like motif to modulate cytokine release .
16899508	0	transient_receptor_potential_canonical_1	17,57	TRPC1	59,64	transient receptor potential canonical 1	TRPC1	7220	7220	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|appos|END_ENTITY	Up-regulation of transient_receptor_potential_canonical_1 -LRB- TRPC1 -RRB- following sarco -LRB- endo -RRB- plasmic_reticulum_Ca2 + _ ATPase 2 gene silencing promotes cell survival : a potential role for TRPC1 in Darier 's _ disease .
17289052	0	transient_receptor_potential_canonical_1	15,55	TRPC1	57,62	transient receptor potential canonical 1	TRPC1	7220	7220	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of transient_receptor_potential_canonical_1 -LRB- TRPC1 -RRB- in angiotensin_II-induced vascular smooth muscle cell hypertrophy .
24563462	0	transient_receptor_potential_canonical_4	78,118	TRPC4	120,125	transient receptor potential canonical 4	TRPC4	22066(Tax:10090)	22066(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Trans-activation_response _ -LRB- TAR -RRB- _ RNA-binding_protein_2 is a novel modulator of transient_receptor_potential_canonical_4 -LRB- TRPC4 -RRB- protein .
18177730	0	transient_receptor_potential_canonical_type_3	15,60	TRPC3	62,67	transient receptor potential canonical type 3	TRPC3	7222	7222	Gene	Gene	Association|nmod|START_ENTITY Association|appos|END_ENTITY	Association of transient_receptor_potential_canonical_type_3 -LRB- TRPC3 -RRB- channel transcripts with proinflammatory cytokines .
25897313	0	transient_receptor_potential_cation_channel	53,96	TRPA1	46,51	transient receptor potential cation channel	TRPA1	8989	8989	Gene	Gene	activity|appos|START_ENTITY activity|compound|END_ENTITY	The role of flavor and fragrance chemicals in TRPA1 -LRB- transient_receptor_potential_cation_channel , member A1 -RRB- activity associated with allergies .
22298783	0	transient_receptor_potential_cation_channel_subfamily_V_member_4	12,76	TRPV4	78,83	transient receptor potential cation channel subfamily V member 4	TRPV4	59341	59341	Gene	Gene	Function|nmod|START_ENTITY Function|appos|END_ENTITY	Function of transient_receptor_potential_cation_channel_subfamily_V_member_4 -LRB- TRPV4 -RRB- as a mechanical transducer in flow-sensitive segments of renal collecting duct system .
24242951	0	transient_receptor_potential_channel_1	8,46	TRPC1	48,53	transient receptor potential channel 1	TRPC1	22063(Tax:10090)	22063(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of transient_receptor_potential_channel_1 -LRB- TRPC1 -RRB- in glutamate-induced cell death in the hippocampal cell line HT22 .
12529379	0	transient_receptor_potential_melastatin_2	42,83	TRPM2	85,90	transient receptor potential melastatin 2	TRPM2	7226	7226	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Critical intracellular Ca2 + dependence of transient_receptor_potential_melastatin_2 -LRB- TRPM2 -RRB- cation channel activation .
22421018	0	transient_receptor_potential_melastatin_8	58,99	TRPM8	101,106	transient receptor potential melastatin 8	TRPM8	171384(Tax:10116)	171384(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	The design and synthesis of novel , phosphonate-containing transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- antagonists .
23411075	0	transient_receptor_potential_melastatin_8	34,75	TRPM8	77,82	transient receptor potential melastatin 8	TRPM8	486170(Tax:9615)	486170(Tax:9615)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Arylglycine derivatives as potent transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- antagonists .
24597733	0	transient_receptor_potential_melastatin_8	81,122	TRPM8	124,129	transient receptor potential melastatin 8	TRPM8	79054	79054	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient_receptor_potential_melastatin_8 -LRB- TRPM8 -RRB- antagonists .
22329507	0	transient_receptor_potential_melastatin_type_8	66,112	TRPM8	114,119	transient receptor potential melastatin type 8	TRPM8	171384(Tax:10116)	171384(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Fused piperidines as a novel class of potent and orally available transient_receptor_potential_melastatin_type_8 -LRB- TRPM8 -RRB- antagonists .
16174775	0	transient_receptor_potential_melastatine_family_member_8	37,93	TRPM8	95,100	transient receptor potential melastatine family member 8	TRPM8	79054	79054	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Novel role of cold/menthol-sensitive transient_receptor_potential_melastatine_family_member_8 -LRB- TRPM8 -RRB- in the activation of store-operated channels in LNCaP human prostate_cancer epithelial cells .
25837939	0	transient_receptor_potential_subfamily_C_member_3	78,127	TRPC3	129,134	transient receptor potential subfamily C member 3	TRPC3	7222	7222	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between the rs1465040 single-nucleotide polymorphism close to the transient_receptor_potential_subfamily_C_member_3 -LRB- TRPC3 -RRB- gene and postoperative analgesic requirements .
23058884	0	transient_receptor_potential_vanilloid	50,88	TRPV1	90,95	transient receptor potential vanilloid	TRPV1	7442	7442	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Discovery of novel pyrrolopyridazine scaffolds as transient_receptor_potential_vanilloid -LRB- TRPV1 -RRB- antagonists .
17660385	0	transient_receptor_potential_vanilloid-1	161,201	TRPV1	203,208	transient receptor potential vanilloid-1	TRPV1	7442	7442	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	-LSB- 3H -RSB- A-778317 -LSB- 1 - -LRB- -LRB- R -RRB- -5 - tert-butyl-indan-1-yl -RRB- -3 - isoquinolin-5-yl-urea -RSB- : a novel , stereoselective , high-affinity antagonist is a useful radioligand for the human transient_receptor_potential_vanilloid-1 -LRB- TRPV1 -RRB- receptor .
22870787	0	transient_receptor_potential_vanilloid_1	59,99	TRPV-1	101,107	transient receptor potential vanilloid 1	TRPV-1	7442	7442	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between single nucleotide polymorphisms of the transient_receptor_potential_vanilloid_1 -LRB- TRPV-1 -RRB- gene and patients with irritable_bowel_syndrome in Korean populations .
15913603	0	transient_receptor_potential_vanilloid_1	18,58	TRPV1	60,65	transient receptor potential vanilloid 1	TRPV1	7442	7442	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- in LNCaP and PC-3_prostate_cancer cells and in human prostate tissue .
16037081	0	transient_receptor_potential_vanilloid_1	14,54	TRPV1	56,61	transient receptor potential vanilloid 1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- by resiniferatoxin .
17560936	0	transient_receptor_potential_vanilloid_1	14,54	TRPV1	56,61	transient receptor potential vanilloid 1	TRPV1	7442	7442	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- in synovial fibroblasts from patients with osteoarthritis and rheumatoid_arthritis .
17937985	0	transient_receptor_potential_vanilloid_1	30,70	TRPV1	72,77	transient receptor potential vanilloid 1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Trisubstituted_pyrimidines as transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists with improved solubility .
18386885	0	transient_receptor_potential_vanilloid_1	48,88	TRPV1	90,95	transient receptor potential vanilloid 1	TRPV1	7442	7442	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Design and synthesis of peripherally restricted transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists .
19344705	0	transient_receptor_potential_vanilloid_1	19,59	TRPV1	61,66	transient receptor potential vanilloid 1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|appos|END_ENTITY	Involvement of the transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- in the development of acute_visceral_hyperalgesia during colorectal_distension in rats .
20411352	0	transient_receptor_potential_vanilloid_1	12,52	TRPV1	54,59	transient receptor potential vanilloid 1	TRPV1	193034(Tax:10090)	193034(Tax:10090)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	The role of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- receptors in dextran sulfate-induced colitis in mice .
20534382	0	transient_receptor_potential_vanilloid_1	10,50	TRPV1	52,57	transient receptor potential vanilloid 1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Effect of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- receptor antagonist compounds SB705498 , BCTC and AMG9810 in rat models of thermal_hyperalgesia measured with an increasing-temperature water bath .
22528458	0	transient_receptor_potential_vanilloid_1	84,124	TRPV1	126,131	transient receptor potential vanilloid 1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Effect of surgical and chemical sensory denervation on non-neural expression of the transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- receptors in the rat .
22957803	0	transient_receptor_potential_vanilloid_1	63,103	TRPV1	105,110	transient receptor potential vanilloid 1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	2 - -LRB- 3-fluoro-4-methylsulfonylaminophenyl -RRB- propanamides as potent transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists : structure-activity relationships of 2-amino derivatives in the N - -LRB- 6-trifluoromethylpyridin-3-ylmethyl -RRB- C-region .
23796768	0	transient_receptor_potential_vanilloid_1	142,182	TRPV1	184,189	transient receptor potential vanilloid 1	TRPV1	7442	7442	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Design and synthesis of conformationally restricted capsaicin analogues based in the 1 , _ 3 , _ 4-thiadiazole heterocycle reveal a novel family of transient_receptor_potential_vanilloid_1 -LRB- TRPV1 -RRB- antagonists .
18355916	0	transient_receptor_potential_vanilloid_4	44,84	TRPV4	86,91	transient receptor potential vanilloid 4	TRPV4	59341	59341	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Dependence of regulatory volume decrease on transient_receptor_potential_vanilloid_4 -LRB- TRPV4 -RRB- expression in human corneal epithelial cells .
23288842	0	transient_receptor_potential_vanilloid_4	49,89	TRPV4	91,96	transient receptor potential vanilloid 4	TRPV4	59341	59341	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Protease-activated_receptor_2 -LRB- PAR2 -RRB- protein and transient_receptor_potential_vanilloid_4 -LRB- TRPV4 -RRB- protein coupling is required for sustained inflammatory signaling .
21795703	0	transient_receptor_potential_vanilloid_5	12,52	TRPV5	54,59	transient receptor potential vanilloid 5	TRPV5	56302	56302	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Role of the transient_receptor_potential_vanilloid_5 -LRB- TRPV5 -RRB- protein N terminus in channel activity , tetramerization , and trafficking .
24340836	0	transient_receptor_potential_vanilloid_receptor-1	40,89	TRPV1	91,96	transient receptor potential vanilloid receptor-1	TRPV1	7442	7442	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of the M3151 variant in the transient_receptor_potential_vanilloid_receptor-1 -LRB- TRPV1 -RRB- gene with type 1 diabetes in an Ashkenazi Jewish population .
26563747	0	transient_receptor_potential_vanilloid_type_1	23,68	TRPV1	70,75	transient receptor potential vanilloid type 1	TRPV1	7442	7442	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Dopamine modulation of transient_receptor_potential_vanilloid_type_1 -LRB- TRPV1 -RRB- receptor in dorsal root ganglia neurons .
24981175	0	transketolase	38,51	Akt	0,3	transketolase	Akt	7086	207	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Akt phosphorylation and regulation of transketolase is a nodal point for amino_acid control of purine synthesis .
26212545	0	transketolase	49,62	ERK	80,83	transketolase	ERK	7086	5594	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate_carcinoma cells .
9521875	0	transketolase	10,23	TKT	25,28	transketolase	TKT	21881(Tax:10090)	21881(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The mouse transketolase -LRB- TKT -RRB- gene : cloning , characterization , and functional promoter analysis .
17351395	0	transketolase	32,45	TKTL1	4,9	transketolase	TKTL1	7086	8277	Gene	Gene	activity|compound|START_ENTITY influences|dobj|activity influences|nsubj|gene gene|compound|END_ENTITY	The TKTL1 gene influences total transketolase activity and cell proliferation in human colon_cancer LoVo cells .
23261987	0	transketolase	38,51	TKTL1	31,36	transketolase	TKTL1	7086	8277	Gene	Gene	protein|appos|START_ENTITY protein|appos|END_ENTITY	Is transketolase-like protein , TKTL1 , transketolase ?
9387133	0	transketolase	58,71	erythropoietin	147,161	transketolase	erythropoietin	7086	2056	Gene	Gene	START_ENTITY|nmod|therapy therapy|compound|END_ENTITY	Comparison of the thiamine level in blood and erythrocyte transketolase activity in hemodialyzed and nondialyzed patients during recombinant human erythropoietin therapy .
20592357	0	transketolase-like_1_protein	14,42	TKTL1	44,49	transketolase-like 1 protein	TKTL1	8277	8277	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of transketolase-like_1_protein -LRB- TKTL1 -RRB- in human endometrial_cancer .
15006423	0	translationally_controlled_tumor_protein	63,103	TCTP	105,109	translationally controlled tumor protein	TCTP	7178	7178	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and expression of a mammalian homologue of a translationally_controlled_tumor_protein -LRB- TCTP -RRB- gene from Penaeus_monodon shrimp .
17894822	0	translationally_controlled_tumor_protein	13,53	TCTP	55,59	translationally controlled tumor protein	TCTP	7178	7178	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of translationally_controlled_tumor_protein -LRB- TCTP -RRB- by transcriptional and post-transcriptional mechanisms .
18630514	0	translationally_controlled_tumor_protein	28,68	TCTP	70,74	translationally controlled tumor protein	TCTP	116646(Tax:10116)	116646(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Messenger RNA expression of translationally_controlled_tumor_protein -LRB- TCTP -RRB- in liver regeneration and cancer .
19060111	0	translationally_controlled_tumor_protein	30,70	TCTP	20,24	translationally controlled tumor protein	TCTP	820916(Tax:3702)	820916(Tax:3702)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of TCTP , the translationally_controlled_tumor_protein , from Arabidopsis_thaliana .
21865235	0	translationally_controlled_tumor_protein	14,54	TCTP	56,60	translationally controlled tumor protein	TCTP	22070(Tax:10090)	22070(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of translationally_controlled_tumor_protein -LRB- TCTP -RRB- in the uterus of mice of early pregnancy and its possible significance during embryo implantation .
23933269	0	translationally_controlled_tumor_protein	95,135	TCTP	137,141	translationally controlled tumor protein	TCTP	7178	7178	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	cDNA cloning , genomic organization and expression analysis during somatic embryogenesis of the translationally_controlled_tumor_protein -LRB- TCTP -RRB- gene from Japanese larch -LRB- Larix leptolepis -RRB- .
24623877	0	translationally_controlled_tumor_protein	14,54	TCTP	56,60	translationally controlled tumor protein	TCTP	7178	7178	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of translationally_controlled_tumor_protein -LRB- TCTP -RRB- gene of Dirofilaria_immitis guided by transcriptomic screening .
16730713	0	translationally_controlled_tumor_protein	50,90	sorting_nexin_6	94,109	translationally controlled tumor protein	sorting nexin 6	7178	58533	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of Na,K-ATPase-suppressive activity of translationally_controlled_tumor_protein by sorting_nexin_6 .
22889834	0	translin-associated_factor_X	74,102	Cb1	14,17	translin-associated factor X	Cb1	7257	1268	Gene	Gene	linked|nmod|START_ENTITY linked|nsubjpass|END_ENTITY	Phospholipase Cb1 is linked to RNA interference of specific genes through translin-associated_factor_X .
11278549	0	translin-associated_factor_X	6,34	TB-RBP	94,100	translin-associated factor X	TB-RBP	7257	7247	Gene	Gene	Trax|appos|START_ENTITY inhibits|nsubj|Trax inhibits|dobj|the the|nmod|END_ENTITY	Trax -LRB- translin-associated_factor_X -RRB- , a primarily cytoplasmic protein , inhibits the binding of TB-RBP -LRB- translin -RRB- to RNA .
22427937	0	translin-associated_factor_X	48,76	TRAX	78,82	translin-associated factor X	TRAX	7257	7257	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Identification of nucleic acid binding sites on translin-associated_factor_X -LRB- TRAX -RRB- protein .
21683752	0	translin-associated_factor_X	28,56	TSNAX	63,68	translin-associated factor X	TSNAX	7257	7257	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Lack of association between translin-associated_factor_X gene -LRB- TSNAX -RRB- and methamphetamine dependence in the Japanese population .
9419343	0	translocase_of_inner_mitochondrial_membrane	30,73	Tim44	75,80	translocase of inner mitochondrial membrane	Tim44	10469	10469	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of mammalian translocase_of_inner_mitochondrial_membrane -LRB- Tim44 -RRB- isolated from diabetic_newborn_mouse_kidney .
21338289	0	translocated_in_liposarcoma	17,44	PGC-1a	0,6	translocated in liposarcoma	PGC-1a	2521	10891	Gene	Gene	activity|compound|START_ENTITY regulates|dobj|activity regulates|nsubj|END_ENTITY	PGC-1a regulates translocated_in_liposarcoma activity : role in oxidative stress gene expression .
11278855	0	translocated_in_liposarcoma	40,67	TLS	35,38	translocated in liposarcoma	TLS	2521	2521	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the pro-oncoprotein TLS -LRB- translocated_in_liposarcoma -RRB- in nuclear factor-kappa B p65-mediated transcription as a coactivator .
21320609	0	translocator_protein	39,59	TSPO	61,65	translocator protein	TSPO	706	706	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Age and disease related changes in the translocator_protein -LRB- TSPO -RRB- system in the human brain : positron emission tomography measurements with -LSB- 11C -RSB- vinpocetine .
21417480	0	translocator_protein	38,58	TSPO	60,64	translocator protein	TSPO	706	12257(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of the 18 kDa translocator_protein -LRB- TSPO -RRB- by neoplastic and inflammatory cells in mouse tumors of breast_cancer .
23525219	0	translocator_protein	34,54	TSPO	56,60	translocator protein	TSPO	24230(Tax:10116)	24230(Tax:10116)	Gene	Gene	activation|nmod|START_ENTITY activation|appos|END_ENTITY	Drug ligand-induced activation of translocator_protein -LRB- TSPO -RRB- stimulates steroid production by aged brown Norway_rat Leydig cells .
25889665	0	translocator_protein	27,47	TSPO	49,53	translocator protein	TSPO	706	706	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Anxiolytic-like effects of translocator_protein -LRB- TSPO -RRB- ligand ZBD-2 in an animal model of chronic_pain .
25889665	0	translocator_protein	27,47	TSPO	49,53	translocator protein	TSPO	706	706	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Anxiolytic-like effects of translocator_protein -LRB- TSPO -RRB- ligand ZBD-2 in an animal model of chronic_pain .
22378763	0	translocator_protein	30,50	Tspo	52,56	translocator protein	Tspo	12257(Tax:10090)	12257(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|appos|END_ENTITY	Transcriptional regulation of translocator_protein -LRB- Tspo -RRB- via a SINE B2-mediated natural antisense transcript in MA-10 Leydig cells .
20600583	0	translocator_protein_18_kDa	14,41	TSPO	43,47	translocator protein 18 kDa	TSPO	706	706	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of translocator_protein_18_kDa -LRB- TSPO -RRB- expression in health and disease states .
22348614	0	translocator_protein_18_kDa	32,59	TSPO	61,65	translocator protein 18 kDa	TSPO	706	706	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of the translocator_protein_18_kDa -LRB- TSPO -RRB- in testicular germ cells .
18330929	0	transmembrane_inner_ear	4,27	tmie	29,33	transmembrane inner ear	tmie	555430(Tax:7955)	555430(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The transmembrane_inner_ear -LRB- tmie -RRB- gene contributes to vestibular and lateral line development and function in the zebrafish -LRB- Danio_rerio -RRB- .
20386877	0	transmembrane_protein_27	12,36	TMEM27	38,44	transmembrane protein 27	TMEM27	57393	57393	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of transmembrane_protein_27 -LRB- TMEM27 -RRB- in islet physiology and its potential use as a beta cell mass biomarker .
11741327	0	transmembrane_tryptase	35,57	MITF	10,14	transmembrane tryptase	MITF	26945(Tax:10090)	17342(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY Effect|nmod|gene Effect|nmod|END_ENTITY	Effect of MITF on transcription of transmembrane_tryptase gene in cultured mast cells of mice .
12194977	0	transmembrane_tryptase	53,75	TMT	77,80	transmembrane tryptase	TMT	25823	25823	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Biochemical and functional characterization of human transmembrane_tryptase -LRB- TMT -RRB- / tryptase gamma .
9562372	0	transporter_associated_with_antigen_presentation	69,117	TAP	119,122	transporter associated with antigen presentation	TAP	8615	8615	Gene	Gene	polymorphism|compound|START_ENTITY polymorphism|appos|END_ENTITY	Peptide transport in human lymphoblastoid and tumor cells : effect of transporter_associated_with_antigen_presentation -LRB- TAP -RRB- polymorphism .
14558951	0	transporter_associated_with_antigen_processing	15,61	TAP	63,66	transporter associated with antigen processing	TAP	6890	6890	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of transporter_associated_with_antigen_processing -LRB- TAP -RRB- in childhood acute_leukemia and its clinical significance -RSB- .
14579270	0	transporter_associated_with_antigen_processing	53,99	TAP	101,104	transporter associated with antigen processing	TAP	100329838(Tax:8355)	100329838(Tax:8355)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Two highly divergent ancient allelic lineages of the transporter_associated_with_antigen_processing -LRB- TAP -RRB- gene in Xenopus : further evidence for co-evolution among MHC class I region genes .
16690408	0	transporter_associated_with_antigen_processing	42,88	TAP	90,93	transporter associated with antigen processing	TAP	6890	6890	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	Pemphigus_vulgaris is associated with the transporter_associated_with_antigen_processing -LRB- TAP -RRB- system .
24196954	0	transporter_associated_with_antigen_processing	41,87	TAP	89,92	transporter associated with antigen processing	TAP	6890	6890	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Analyses of conformational states of the transporter_associated_with_antigen_processing -LRB- TAP -RRB- protein in a native cellular membrane environment .
8267790	0	transporter_associated_with_antigen_processing	28,74	TAP	76,79	transporter associated with antigen processing	TAP	6890	6890	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Haplotypic variation of the transporter_associated_with_antigen_processing -LRB- TAP -RRB- genes and their extension of HLA class II region haplotypes .
10220507	0	transporter_associated_with_antigen_processing	15,61	TAP2	65,69	transporter associated with antigen processing	TAP2	6890	6891	Gene	Gene	gene|compound|START_ENTITY gene|compound|END_ENTITY	Involvement of transporter_associated_with_antigen_processing 2 -LRB- TAP2 -RRB- gene polymorphisms in hepatitis_C_virus infection .
21299467	0	transporter_associated_with_antigen_processing	42,88	protein_disulfide_isomerase	146,173	transporter associated with antigen processing	protein disulfide isomerase	6890	64714	Gene	Gene	transfer|nmod|START_ENTITY transfer|nmod|END_ENTITY	Redox-regulated peptide transfer from the transporter_associated_with_antigen_processing to major histocompatibility complex class I molecules by protein_disulfide_isomerase .
18071882	0	transporter_associated_with_antigen_processing_2	16,64	TAP2	66,70	transporter associated with antigen processing 2	TAP2	6891	6891	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Significance of transporter_associated_with_antigen_processing_2 -LRB- TAP2 -RRB- gene polymorphisms in susceptibility to dengue_viral_infection .
22872640	0	transportin_3	39,52	TNPO3	62,67	transportin 3	TNPO3	23534	23534	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Interaction of the HIV-1 intasome with transportin_3 protein -LRB- TNPO3 or TRN-SR2 -RRB- .
12553440	0	transthyretin	22,35	C-reactive_protein	0,18	transthyretin	C-reactive protein	7276	1401	Gene	Gene	ratio|compound|START_ENTITY END_ENTITY|nmod|ratio	C-reactive_protein to transthyretin ratio for the early diagnosis and follow-up of postoperative_infection .
10675660	0	transthyretin	45,58	TTR	60,63	transthyretin	TTR	7276	7276	Gene	Gene	mutations|compound|START_ENTITY mutations|appos|END_ENTITY	A new diagnostic procedure to detect unknown transthyretin -LRB- TTR -RRB- mutations in familial_amyloidotic_polyneuropathy -LRB- FAP -RRB- .
1618497	0	transthyretin	27,40	TTR	42,45	transthyretin	TTR	7276	7276	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Molecular diagnosis of the transthyretin -LRB- TTR -RRB- Met111 mutation in familial_amyloid_cardiomyopathy of Danish origin .
27051017	0	transthyretin	66,79	TTR	81,84	transthyretin	TTR	7276	7276	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between a point mutation at the -743 - bp region of the transthyretin -LRB- TTR -RRB- gene and familial_vitreous_amyloidosis .
3025666	0	transthyretin	49,62	prealbumin	37,47	transthyretin	prealbumin	22139(Tax:10090)	22139(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Transcriptional control of the mouse prealbumin -LRB- transthyretin -RRB- gene : both promoter sequences and a distinct enhancer are cell specific .
15319482	0	transthyretin-like_protein	16,42	BRASSINOSTEROID-INSENSITIVE_1	71,100	transthyretin-like protein	BRASSINOSTEROID-INSENSITIVE 1	835934(Tax:3702)	830095(Tax:3702)	Gene	Gene	substrate|nsubj|START_ENTITY substrate|nmod|END_ENTITY	The Arabidopsis transthyretin-like_protein is a potential substrate of BRASSINOSTEROID-INSENSITIVE_1 .
9023354	0	trap	24,28	alpha-E-catenin	3,18	trap	alpha-E-catenin	11433(Tax:10090)	12385(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY mutation|amod|END_ENTITY	An alpha-E-catenin gene trap mutation defines its function in preimplantation development .
22842654	0	trefoil_factor_1	68,84	trefoil_factor_1	8,24	trefoil factor 1	trefoil factor 1	7031	7031	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of trefoil_factor_1 in gastric_cancer and relationship between trefoil_factor_1 and gastrokine_1 .
22842654	0	trefoil_factor_1	8,24	trefoil_factor_1	68,84	trefoil factor 1	trefoil factor 1	7031	7031	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of trefoil_factor_1 in gastric_cancer and relationship between trefoil_factor_1 and gastrokine_1 .
23000412	0	trefoil_factor_2	18,34	Sp3	74,77	trefoil factor 2	Sp3	7032	6670	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	The regulation of trefoil_factor_2 expression by the transcription factor Sp3 .
12054609	0	trefoil_factor_2	21,37	TFF2	39,43	trefoil factor 2	TFF2	7032	7032	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Autoinduction of the trefoil_factor_2 -LRB- TFF2 -RRB- promoter requires an upstream cis-acting element .
24738314	0	trefoil_factor_3	36,52	CXCR4	63,68	trefoil factor 3	CXCR4	7033	7852	Gene	Gene	expression|nmod|START_ENTITY -LSB-|dobj|expression axis|dep|-LSB- axis|nummod|END_ENTITY	-LSB- The expression and significance of trefoil_factor_3 and SDF-1 / CXCR4 biological axis in papillary_thyroid_carcinoma -RSB- .
12663147	0	trefoil_factor_3	36,52	ITF	53,56	trefoil factor 3	ITF	7033	7033	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Ontogeny and prenatal expression of trefoil_factor_3 / ITF in the human intestine .
15177874	0	trefoil_factor_family_1	32,55	TFF1	57,61	trefoil factor family 1	TFF1	7031	117270(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Synergistic effects of systemic trefoil_factor_family_1 -LRB- TFF1 -RRB- peptide and epidermal_growth_factor in a rat model of colitis .
17118693	0	trefoil_factor_family_2	71,94	Peroxisome_proliferator-activated_receptor_gamma	0,48	trefoil factor family 2	Peroxisome proliferator-activated receptor gamma	7032	5468	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- regulates trefoil_factor_family_2 -LRB- TFF2 -RRB- expression in gastric epithelial cells .
17118693	0	trefoil_factor_family_2	71,94	TFF2	96,100	trefoil factor family 2	TFF2	7032	7032	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma -LRB- PPARgamma -RRB- regulates trefoil_factor_family_2 -LRB- TFF2 -RRB- expression in gastric epithelial cells .
15821928	0	trefoil_factor_family_protein_1	12,43	TFF1	45,49	trefoil factor family protein 1	TFF1	7031	7031	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Analysis of trefoil_factor_family_protein_1 -LRB- TFF1 , pS2 -RRB- expression in chronic cholecystitis and gallbladder_carcinoma .
11404018	0	trehalase	51,60	Treh	62,66	trehalase	Treh	58866(Tax:10090)	58866(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Cloning , characterization and mapping of the mouse trehalase -LRB- Treh -RRB- gene .
10901163	0	trehalose-6-phosphate_synthase	78,108	TPS1	110,114	trehalose-6-phosphate synthase	TPS1	852423(Tax:4932)	852423(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic engineering of drought resistant potato plants by introduction of the trehalose-6-phosphate_synthase -LRB- TPS1 -RRB- gene from Saccharomyces_cerevisiae .
24951963	0	trehalose-6-phosphate_synthase	60,90	TPS1	97,101	trehalose-6-phosphate synthase	TPS1	852423(Tax:4932)	852423(Tax:4932)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Enhanced freeze tolerance of baker 's _ yeast by overexpressed trehalose-6-phosphate_synthase gene -LRB- TPS1 -RRB- and deleted trehalase genes in frozen dough .
15752068	0	triacylglycerol_hydrolase	42,67	C/EBPalpha	0,10	triacylglycerol hydrolase	C/EBPalpha	104158(Tax:10090)	12606(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY activates|dobj|transcription activates|nsubj|END_ENTITY	C/EBPalpha activates the transcription of triacylglycerol_hydrolase in 3T3-L1 adipocytes .
9737879	0	triadin	61,68	skeletal_muscle_ryanodine_receptor	23,57	triadin	skeletal muscle ryanodine receptor	100009519(Tax:9986)	100009540(Tax:9986)	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Dual regulation of the skeletal_muscle_ryanodine_receptor by triadin and calsequestrin .
9513081	0	triakontatetraneuropeptide	14,40	TTN	42,45	triakontatetraneuropeptide	TTN	25045(Tax:10116)	25045(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of the triakontatetraneuropeptide -LRB- TTN -RRB- on corticosteroid secretion by the frog adrenal gland .
18593568	0	tribbles	25,33	Trb2	0,4	tribbles	Trb2	43999(Tax:7227)	217410(Tax:10090)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	Trb2 , a mouse homolog of tribbles , is dispensable for kidney and mouse development .
20675060	0	tribbles_homolog_3	12,30	TRIB3	32,37	tribbles homolog 3	TRIB3	106505984	106505984	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The porcine tribbles_homolog_3 -LRB- TRIB3 -RRB- gene : Identification of a missense mutation and association analysis with meat quality and production traits in Italian heavy pigs .
21549750	0	triggering_receptor_expressed_on_myeloid_cells-1	27,75	TREM-1	77,83	triggering receptor expressed on myeloid cells-1	TREM-1	54210	54210	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and function of triggering_receptor_expressed_on_myeloid_cells-1 -LRB- TREM-1 -RRB- on canine neutrophils .
20197606	0	triggering_receptor_expressed_on_myeloid_cells-1	63,111	calcitonin_gene-related_peptide	10,41	triggering receptor expressed on myeloid cells-1	calcitonin gene-related peptide	54210	796	Gene	Gene	expression|nmod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of calcitonin_gene-related_peptide on the expression of triggering_receptor_expressed_on_myeloid_cells-1 in lipopolysaccharide-induced macrophages .
22989616	0	trio	19,23	CXCL11	62,68	trio	CXCL11	7204	6373	Gene	Gene	START_ENTITY|dep|crosstalk crosstalk|nmod|END_ENTITY	Chemokine_receptor trio : CXCR3 , CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12 .
21984829	0	triose-phosphate_isomerase	101,127	TIM	129,132	triose-phosphate isomerase	TIM	3169211(Tax:300852)	3169211(Tax:300852)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	In vivo , in vitro , and x-ray crystallographic analyses suggest the involvement of an uncharacterized triose-phosphate_isomerase -LRB- TIM -RRB- barrel protein in protection against oxidative stress .
9864381	0	triosephosphate_isomerase	14,39	TPI	65,68	triosephosphate isomerase	TPI	7167	7167	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of triosephosphate_isomerase -LRB- TPI -RRB- gene expression in TPI deficient_lymphoblastoid_cells .
12747415	0	triosephosphate_isomerase	88,113	tpi	115,118	triosephosphate isomerase	tpi	7167	7167	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotypic differentiation of twelve Clostridium species by polymorphism analysis of the triosephosphate_isomerase -LRB- tpi -RRB- gene .
24449583	0	tripartite_motif-containing_protein_21	30,68	Estrogen_receptor_a	0,19	tripartite motif-containing protein 21	Estrogen receptor a	6737	2099	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Estrogen_receptor_a regulates tripartite_motif-containing_protein_21 expression , contributing to dysregulated cytokine production in systemic_lupus_erythematosus .
14766228	0	tristetraprolin	22,37	CAN/Nup214	59,69	tristetraprolin	CAN/Nup214	22695(Tax:10090)	8021	Gene	Gene	association|nmod|START_ENTITY association|nmod|END_ENTITY	Direct association of tristetraprolin with the nucleoporin CAN/Nup214 .
21515794	0	tristetraprolin	72,87	IFN-gamma	54,63	tristetraprolin	IFN-gamma	7538	3458	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Posttranscriptional regulation of IL-23 expression by IFN-gamma through tristetraprolin .
21515794	0	tristetraprolin	72,87	IL-23	34,39	tristetraprolin	IL-23	7538	51561	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|regulation regulation|nmod|END_ENTITY	Posttranscriptional regulation of IL-23 expression by IFN-gamma through tristetraprolin .
14688255	0	tristetraprolin	31,46	MAPKAP_kinase_2	0,15	tristetraprolin	MAPKAP kinase 2	22695(Tax:10090)	17164(Tax:10090)	Gene	Gene	phosphorylates|dobj|START_ENTITY phosphorylates|nsubj|END_ENTITY	MAPKAP_kinase_2 phosphorylates tristetraprolin on in vivo sites including Ser178 , a site required for 14-3-3 binding .
19738286	0	tristetraprolin	25,40	NF-kappaB	62,71	tristetraprolin	NF-kappaB	22695(Tax:10090)	18033(Tax:10090)	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|END_ENTITY	RNA-destabilizing factor tristetraprolin negatively regulates NF-kappaB signaling .
21964062	0	tristetraprolin	24,39	Protor-2	0,8	tristetraprolin	Protor-2	7538	79899	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress .
17517366	0	tristetraprolin	26,41	TTP	43,46	tristetraprolin	TTP	7538	7538	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Comparative expression of tristetraprolin -LRB- TTP -RRB- family member transcripts in normal human tissues and cancer cell lines .
24978456	0	tristetraprolin	23,38	hnRNP_F	0,7	tristetraprolin	hnRNP F	7538	3185	Gene	Gene	complexes|nmod|START_ENTITY complexes|compound|END_ENTITY	hnRNP_F complexes with tristetraprolin and stimulates ARE-mRNA decay .
19435930	0	tristetraprolin	14,29	interleukin-1_beta	44,62	tristetraprolin	interleukin-1 beta	7538	3553	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Regulation of tristetraprolin expression by interleukin-1_beta and dexamethasone in human pulmonary epithelial cells : roles for nuclear factor-kappa B and p38_mitogen-activated_protein_kinase .
23102618	0	tristetraprolin	49,64	mTOR	0,4	tristetraprolin	mTOR	7538	21977(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	mTOR regulates cellular iron homeostasis through tristetraprolin .
12754205	0	tristetraprolin	30,45	transforming_growth_factor-beta	49,80	tristetraprolin	transforming growth factor-beta	7538	7040	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of tristetraprolin by transforming_growth_factor-beta in human T cells .
14679154	0	tristetraprolin	48,63	tumor_necrosis_factor-alpha	82,109	tristetraprolin	tumor necrosis factor-alpha	7538	7124	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor_necrosis_factor-alpha expression .
12699618	0	trithorax	33,42	ATX-1	0,5	trithorax	ATX-1	41737(Tax:7227)	842940(Tax:3702)	Gene	Gene	homolog|nmod|START_ENTITY END_ENTITY|appos|homolog	ATX-1 , an Arabidopsis homolog of trithorax , activates flower homeotic genes .
17246389	0	trithorax	78,87	bithorax	65,73	trithorax	bithorax	41737(Tax:7227)	42034(Tax:7227)	Gene	Gene	Locus|dep|START_ENTITY Locus|amod|END_ENTITY	Homoeosis in Drosophila : The Lethal Syndrome of the Regulator of bithorax -LRB- or trithorax -RRB- Locus and Its Interaction with Other Homoeotic Loci .
1715690	0	trk	40,43	Nerve_growth_factor	0,19	trk	Nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Nerve_growth_factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase_C_gamma_1 .
7508936	0	trk	48,51	alpha_2-macroglobulin	20,41	trk	alpha 2-macroglobulin	59109(Tax:10116)	24153(Tax:10116)	Gene	Gene	START_ENTITY|nsubj|binds binds|amod|END_ENTITY	Monoamine-activated alpha_2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction .
1649007	0	trk	4,7	nerve_growth_factor	69,88	trk	nerve growth factor	18211(Tax:10090)	18049(Tax:10090)	Gene	Gene	kinase|amod|START_ENTITY mediates|nsubj|kinase mediates|dobj|properties properties|nmod|END_ENTITY	The trk tyrosine protein kinase mediates the mitogenic properties of nerve_growth_factor and neurotrophin-3 .
1849459	0	trk	4,7	nerve_growth_factor	46,65	trk	nerve growth factor	4914	310738(Tax:10116)	Gene	Gene	proto-oncogene|compound|START_ENTITY encodes|nsubj|proto-oncogene encodes|dobj|receptor receptor|nmod|END_ENTITY	The trk proto-oncogene encodes a receptor for nerve_growth_factor .
8730779	0	trk	18,21	neurotrophin	32,44	trk	neurotrophin	4914	627	Gene	Gene	family|compound|START_ENTITY Expression|nmod|family Expression|nmod|receptors receptors|compound|END_ENTITY	Expression of the trk family of neurotrophin receptors in developing and adult dorsal root ganglion neurons .
1653651	0	trk	26,29	trkC	0,4	trk	trkC	4914	4916	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	trkC , a new member of the trk family of tyrosine protein kinases , is a receptor for neurotrophin-3 .
11859925	0	trkA	18,22	NGF	49,52	trkA	NGF	4914	4803	Gene	Gene	mutant|nsubj|START_ENTITY mutant|xcomp|exhibiting exhibiting|dobj|binding binding|amod|END_ENTITY	A double cysteine trkA mutant exhibiting reduced NGF binding and delayed Erk signaling .
7985814	0	trkA	85,89	NGF	46,49	trkA	NGF	4914	4803	Gene	Gene	proteins|amod|START_ENTITY binding|dobj|proteins binding|nsubj|changes changes|appos|END_ENTITY	Developmental changes in nerve_growth_factor -LRB- NGF -RRB- binding and NGF receptor proteins trkA and p75 in the facial nerve .
14511333	0	trkA	30,34	Neurotrophin-3	0,14	trkA	Neurotrophin-3	59109(Tax:10116)	81737(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY down-regulates|dobj|mRNA down-regulates|nsubj|END_ENTITY	Neurotrophin-3 down-regulates trkA mRNA , NGF high-affinity binding sites , and associated phenotype in adult DRG neurons .
7868185	0	trkA	87,91	nerve_growth_factor	13,32	trkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	proto-oncogene|compound|START_ENTITY expression|nmod|proto-oncogene responsiveness|nmod|expression responsiveness|nsubj|Induction Induction|nmod|END_ENTITY	Induction of nerve_growth_factor responsiveness in C6-2B glioma cells by expression of trkA proto-oncogene .
7985814	0	trkA	85,89	nerve_growth_factor	25,44	trkA	nerve growth factor	4914	4803	Gene	Gene	proteins|amod|START_ENTITY binding|dobj|proteins binding|nsubj|changes changes|nmod|END_ENTITY	Developmental changes in nerve_growth_factor -LRB- NGF -RRB- binding and NGF receptor proteins trkA and p75 in the facial nerve .
8195465	0	trkA	35,39	nerve_growth_factor	118,137	trkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY detection|nmod|mRNA distribution|nmod|detection distribution|acl|colocalization colocalization|nmod|END_ENTITY	In situ hybridization detection of trkA mRNA in brain : distribution , colocalization with p75NGFR and up-regulation by nerve_growth_factor .
8847739	0	trkA	49,53	nerve_growth_factor	8,27	trkA	nerve growth factor	59109(Tax:10116)	310738(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY expression|nmod|mRNA Role|nmod|expression Role|nmod|END_ENTITY	Role of nerve_growth_factor in the expression of trkA mRNA in cultured embryonic rat basal forebrain cholinergic neurons .
8940397	0	trkA	61,65	nerve_growth_factor	15,34	trkA	nerve growth factor	4914	4803	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|dep|activation	Involvement of nerve_growth_factor in the ovulatory cascade : trkA receptor activation inhibits gap junctional communication between thecal cells .
9204927	0	trkA	4,8	nerve_growth_factor	76,95	trkA	nerve growth factor	396337(Tax:9031)	396466(Tax:9031)	Gene	Gene	receptor|compound|START_ENTITY mediates|nsubj|receptor mediates|dobj|cone cone|acl|turning turning|nmod|source source|nmod|END_ENTITY	The trkA receptor mediates growth cone turning toward a localized source of nerve_growth_factor .
10564362	0	trkB	108,112	BDNF	36,40	trkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells results|dep|expression results|nmod|changes changes|nmod|expression expression|amod|END_ENTITY	Axotomy results in major changes in BDNF expression by dorsal root ganglion cells : BDNF expression in large trkB and trkC cells , in pericellular baskets , and in projections to deep dorsal horn and dorsal column nuclei .
10564362	0	trkB	108,112	BDNF	83,87	trkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Axotomy results in major changes in BDNF expression by dorsal root ganglion cells : BDNF expression in large trkB and trkC cells , in pericellular baskets , and in projections to deep dorsal horn and dorsal column nuclei .
11356095	0	trkB	48,52	BDNF	19,23	trkB	BDNF	100519209	397495(Tax:9823)	Gene	Gene	RNAs|compound|START_ENTITY effect|nmod|RNAs mRNA|nmod|effect mRNA|compound|END_ENTITY	Down-regulation of BDNF mRNA , with no effect on trkB or glucocorticoid receptor m RNAs , in the porcine hippocampus after acute dexamethasone treatment .
11532338	0	trkB	78,82	BDNF	151,155	trkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	tyrosine_kinase_B|appos|START_ENTITY tyrosine_kinase_B|appos|receptor receptor|nmod|brain_derived_neurotrophic_factor brain_derived_neurotrophic_factor|appos|END_ENTITY	Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine_kinase_B -LRB- trkB -RRB- , the high-affinity receptor for brain_derived_neurotrophic_factor -LRB- BDNF -RRB- .
15927371	0	trkB	28,32	BDNF	0,4	trkB	BDNF	396157(Tax:9031)	396186(Tax:9031)	Gene	Gene	levels|amod|START_ENTITY regulation|nmod|levels regulation|compound|END_ENTITY	BDNF and NT-3 regulation of trkB and trkC mRNA levels in the developing chick spinal cord .
21039416	0	trkB	40,44	BDNF	120,124	trkB	BDNF	4915	627	Gene	Gene	antibodies|compound|START_ENTITY characterization|nmod|antibodies reveals|nsubj|characterization reveals|dobj|class class|nmod|agents agents|nmod|study study|nmod|receptor receptor|compound|END_ENTITY	Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptor .
8000564	0	trkB	25,29	BDNF	122,126	trkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	mRNA|amod|START_ENTITY hybridization|nmod|mRNA END_ENTITY|nmod|hybridization	In situ hybridization of trkB and trkC receptor mRNA in rat forebrain and association with high-affinity binding of -LSB- 125I -RSB- BDNF , -LSB- 125I -RSB- NT-4 / 5 and -LSB- 125I -RSB- NT-3 .
8010414	0	trkB	11,15	BDNF	117,121	trkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	immunoreactivity|amod|START_ENTITY Pattern|nmod|immunoreactivity Pattern|appos|END_ENTITY	Pattern of trkB protein-like immunoreactivity in vivo and the in vitro effects of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- on developing cochlear and vestibular neurons .
8625822	0	trkB	18,22	BDNF	47,51	trkB	BDNF	396157(Tax:9031)	396186(Tax:9031)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo .
9728915	0	trkB	18,22	BDNF	93,97	trkB	BDNF	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	mutation|nmod|START_ENTITY causes|nsubj|mutation causes|nmod|effects effects|nmod|responses responses|compound|END_ENTITY	Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses .
9813329	0	trkB	8,12	BDNF	126,130	trkB	BDNF	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|dep|pattern pattern|nmod|expression expression|compound|END_ENTITY	Highest trkB mRNA expression in the entorhinal cortex among hippocampal subregions in the adult rat : contrasting pattern with BDNF mRNA expression .
18752299	0	trkB	117,121	Brain-derived_neurotrophic_factor	0,33	trkB	Brain-derived neurotrophic factor	4915	627	Gene	Gene	mediated|nmod|START_ENTITY mediated|nsubjpass|effects effects|amod|END_ENTITY	Brain-derived_neurotrophic_factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway .
14678891	0	trkB	61,65	brain-derived_neurotrophic_factor	18,51	trkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	-LSB- Amplification of brain-derived_neurotrophic_factor receptor trkB gene and construction of its eukaryotic expression vector -RSB- .
1645620	0	trkB	98,102	brain-derived_neurotrophic_factor	25,58	trkB	brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	tyrosine|amod|START_ENTITY receptor|amod|tyrosine ligands|nmod|receptor ligands|nsubj|factors factors|amod|END_ENTITY	The neurotrophic factors brain-derived_neurotrophic_factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor .
1649702	0	trkB	4,8	brain-derived_neurotrophic_factor	51,84	trkB	brain-derived neurotrophic factor	18212(Tax:10090)	12064(Tax:10090)	Gene	Gene	tyrosine|amod|START_ENTITY kinase|amod|tyrosine receptor|nsubj|kinase receptor|nmod|END_ENTITY	The trkB tyrosine protein kinase is a receptor for brain-derived_neurotrophic_factor and neurotrophin-3 .
1710174	0	trkB	0,4	brain-derived_neurotrophic_factor	39,72	trkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	encodes|nsubj|START_ENTITY encodes|dobj|receptor receptor|nmod|END_ENTITY	trkB encodes a functional receptor for brain-derived_neurotrophic_factor and neurotrophin-3 but not nerve_growth_factor .
8627351	0	trkB	30,34	brain-derived_neurotrophic_factor	81,114	trkB	brain-derived neurotrophic factor	379266(Tax:8355)	378585(Tax:8355)	Gene	Gene	receptors|compound|START_ENTITY occurring|dobj|receptors have|csubj|occurring have|nmod|signaling signaling|amod|END_ENTITY	Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived_neurotrophic_factor signaling .
8670834	0	trkB	46,50	brain-derived_neurotrophic_factor	82,115	trkB	brain-derived neurotrophic factor	4915	627	Gene	Gene	START_ENTITY|nmod|specificity specificity|nmod|END_ENTITY	A splice variant of the neurotrophin receptor trkB with increased specificity for brain-derived_neurotrophic_factor .
8954962	0	trkB	16,20	brain-derived_neurotrophic_factor	66,99	trkB	brain-derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|acl|encoding encoding|nmod|END_ENTITY	Mutation of the trkB gene encoding the high-affinity receptor for brain-derived_neurotrophic_factor in stroke-prone spontaneously hypertensive rats .
1653651	0	trkC	0,4	neurotrophin-3	84,98	trkC	neurotrophin-3	4916	4908	Gene	Gene	receptor|nsubj|START_ENTITY receptor|nmod|END_ENTITY	trkC , a new member of the trk family of tyrosine protein kinases , is a receptor for neurotrophin-3 .
7529173	0	trkC	56,60	neurotrophin-3	24,38	trkC	neurotrophin-3	4916	4908	Gene	Gene	receptors|amod|START_ENTITY END_ENTITY|nmod|receptors	The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin .
8093043	0	trkC	14,18	neurotrophin-3	73,87	trkC	neurotrophin-3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of trkC in a mouse osteoblastic cell line and its response to neurotrophin-3 .
8223273	0	trkC	0,4	neurotrophin-3	21,35	trkC	neurotrophin-3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	trkC , a receptor for neurotrophin-3 , is widely expressed in the developing nervous system and in non-neuronal tissues .
8344249	0	trkC	0,4	neurotrophin-3	22,36	trkC	neurotrophin-3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	encodes|nsubj|START_ENTITY encodes|dobj|receptors receptors|amod|END_ENTITY	trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities .
8494648	0	trkC	8,12	neurotrophin-3	95,109	trkC	neurotrophin-3	29613(Tax:10116)	81737(Tax:10116)	Gene	Gene	locus|compound|START_ENTITY encodes|nsubj|locus encodes|dobj|receptors receptors|acl:relcl|exhibit exhibit|nmod|cells cells|amod|END_ENTITY	The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells .
8621424	0	trkC	127,131	neurotrophin-3	11,25	trkC	neurotrophin-3	4916	4908	Gene	Gene	recognized|nmod|START_ENTITY epitope|acl|recognized mediated|nmod|epitope mediated|nsubj|Binding Binding|nmod|END_ENTITY	Binding of neurotrophin-3 to p75LNGFR , TrkA , and TrkB mediated by a single functional epitope distinct from that recognized by trkC .
9125498	0	trkC	83,87	neurotrophin-3	154,168	trkC	neurotrophin-3	29613(Tax:10116)	81737(Tax:10116)	Gene	Gene	agonists|amod|START_ENTITY neurotrophin-3|nmod|agonists determinants|nmod|neurotrophin-3 determinants|advcl|changing changing|nmod|analogs analogs|amod|END_ENTITY	Specificity determinants in neurotrophin-3 and design of nerve_growth_factor-based trkC agonists by changing central beta-strand bundle residues to their neurotrophin-3 analogs .
9125498	0	trkC	83,87	neurotrophin-3	28,42	trkC	neurotrophin-3	29613(Tax:10116)	81737(Tax:10116)	Gene	Gene	agonists|amod|START_ENTITY END_ENTITY|nmod|agonists	Specificity determinants in neurotrophin-3 and design of nerve_growth_factor-based trkC agonists by changing central beta-strand bundle residues to their neurotrophin-3 analogs .
9405689	0	trkC	41,45	neurotrophin-3	105,119	trkC	neurotrophin-3	18213(Tax:10090)	18205(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY isoforms|nmod|gene deletion|nmod|isoforms suggests|nsubj|deletion suggests|nmod|END_ENTITY	Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis .
1653651	0	trkC	0,4	trk	26,29	trkC	trk	4916	4914	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	trkC , a new member of the trk family of tyrosine protein kinases , is a receptor for neurotrophin-3 .
8682498	0	trkE	25,29	NTRK4	18,23	trkE	NTRK4	780	780	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Assignment of the NTRK4 -LRB- trkE -RRB- gene to chromosome 6p21 .
9842718	0	trol	38,42	eve	25,28	trol	eve	45320(Tax:7227)	36039(Tax:7227)	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Drosophila homeobox gene eve enhances trol , an activator of neuroblast proliferation in the larval CNS .
11327080	0	tropoelastin	42,54	Basic_fibroblast_growth_factor	0,30	tropoelastin	Basic fibroblast growth factor	2006	2247	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Basic_fibroblast_growth_factor suppresses tropoelastin gene expression in cultured human periodontal fibroblasts .
19627254	0	tropoelastin	38,50	Fibulin-4	0,9	tropoelastin	Fibulin-4	2006	30008	Gene	Gene	gene|compound|START_ENTITY expression|nmod|gene regulates|dobj|expression regulates|nsubj|END_ENTITY	Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts .
1945563	0	tropoelastin	17,29	IGF-I	0,5	tropoelastin	IGF-I	25043(Tax:10116)	24482(Tax:10116)	Gene	Gene	synthesis|compound|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	IGF-I stimulates tropoelastin synthesis in neonatal rat pulmonary fibroblasts .
3652657	0	tropoelastin	70,82	Insulin-like_growth_factor_I	0,28	tropoelastin	Insulin-like growth factor I	396441(Tax:9031)	100327329(Tax:9031)	Gene	Gene	synthesis|nmod|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Insulin-like_growth_factor_I , somatomedin_C , induces the synthesis of tropoelastin in aortic tissue .
24148803	0	tropoelastin	21,33	LTBP-2	0,6	tropoelastin	LTBP-2	2006	4053	Gene	Gene	competes|nmod|START_ENTITY competes|nsubj|END_ENTITY	LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin , and is a negative modulator of elastinogenesis .
15233806	0	tropoelastin	49,61	Microfibril-associated_glycoprotein-1	0,37	tropoelastin	Microfibril-associated glycoprotein-1	2006	4237	Gene	Gene	binding|nmod|START_ENTITY binding|compound|END_ENTITY	Microfibril-associated_glycoprotein-1 binding to tropoelastin : multiple binding sites and the role of divalent cations .
15381155	0	tropoelastin	74,86	Microfibril-associated_glycoprotein-1	0,37	tropoelastin	Microfibril-associated glycoprotein-1	2006	4237	Gene	Gene	deposition|compound|START_ENTITY associated|nmod|deposition associated|nsubjpass|END_ENTITY	Microfibril-associated_glycoprotein-1 and fibrillin-2 are associated with tropoelastin deposition in vitro .
25984768	0	tropoelastin	30,42	hTE	44,47	tropoelastin	hTE	2006	10005	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of synthetic human tropoelastin -LRB- hTE -RRB- protein in Nicotiana_tabacum .
25984768	0	tropoelastin	30,42	hTE	44,47	tropoelastin	hTE	2006	10005	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of synthetic human tropoelastin -LRB- hTE -RRB- protein in Nicotiana_tabacum .
20736303	0	tropomodulin-1	32,46	Leiomodin-2	0,11	tropomodulin-1	Leiomodin-2	7111	442721	Gene	Gene	antagonist|nmod|START_ENTITY antagonist|nsubj|END_ENTITY	Leiomodin-2 is an antagonist of tropomodulin-1 at the pointed end of the thin filaments in cardiac muscle .
24801982	0	tropomyosin-related_kinase_B	49,77	Brain-derived_neurotrophic_factor	0,33	tropomyosin-related kinase B	Brain-derived neurotrophic factor	4915	627	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|dep|signaling	Brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced tropomyosin-related_kinase_B -LRB- Trk_B -RRB- signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal_cancer .
23086941	0	tropomyosin-related_kinase_B	36,64	LIM_kinase_1	0,12	tropomyosin-related kinase B	LIM kinase 1	4915	3984	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	LIM_kinase_1 -LRB- LIMK1 -RRB- interacts with tropomyosin-related_kinase_B -LRB- TrkB -RRB- and Mediates brain-derived_neurotrophic_factor -LRB- BDNF -RRB- - induced axonal elongation .
22015740	0	tropomyosin-related_kinase_B	48,76	brain-derived_neurotrophic_factor	14,47	tropomyosin-related kinase B	brain-derived neurotrophic factor	396157(Tax:9031)	396186(Tax:9031)	Gene	Gene	signaling|nsubj|START_ENTITY Activation|parataxis|signaling Activation|nmod|END_ENTITY	Activation of brain-derived_neurotrophic_factor / tropomyosin-related_kinase_B signaling accompanying filial imprinting in domestic chicks -LRB- Gallus_gallus_domesticus -RRB- .
17363372	0	tropomyosin_1	46,59	MicroRNA-21	0,11	tropomyosin 1	MicroRNA-21	7168	406991	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-21 targets the tumor_suppressor gene tropomyosin_1 -LRB- TPM1 -RRB- .
20951040	0	tropomyosin_3	69,82	TPM3	84,88	tropomyosin 3	TPM3	7170	7170	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Congenital fibre_type_disproportion associated with mutations in the tropomyosin_3 -LRB- TPM3 -RRB- gene mimicking congenital_myasthenia .
26286016	0	tropomyosin_receptor_kinase_A	13,42	TrkA	44,48	Tropomyosin receptor kinase A	TrkA	59109(Tax:10116)	59109(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Blocking the tropomyosin_receptor_kinase_A -LRB- TrkA -RRB- receptor inhibits pain behaviour in two rat models of osteoarthritis .
17991742	0	tropomyosin_receptor_kinase_C	22,51	c-Src	0,5	tropomyosin receptor kinase C	c-Src	4916	6714	Gene	Gene	required|nmod|START_ENTITY required|dep|END_ENTITY	c-Src is required for tropomyosin_receptor_kinase_C -LRB- TrkC -RRB- - induced activation of the phosphatidylinositol_3-kinase -LRB- PI3K -RRB- - AKT pathway .
20540510	0	tropomysin_receptor_kinase_C	32,60	TrkC	62,66	tropomysin receptor kinase C	TrkC	4916	4916	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Bivalent diketopiperazine-based tropomysin_receptor_kinase_C -LRB- TrkC -RRB- antagonists .
1856208	0	troponin_C	88,98	troponin_I	127,137	troponin C	troponin I	100301551(Tax:9986)	100009581(Tax:9986)	Gene	Gene	START_ENTITY|nmod|region region|nmod|END_ENTITY	Cross-linking_of_residue_57 in the regulatory domain of a mutant rabbit skeletal muscle troponin_C to the inhibitory region of troponin_I .
8780504	0	troponin_C	172,182	troponin_I	148,158	troponin C	troponin I	100301551(Tax:9986)	100009581(Tax:9986)	Gene	Gene	fragments|nmod|START_ENTITY fragments|amod|END_ENTITY	Photo-cross-linking of rabbit skeletal troponin_I deletion mutants with troponin_C and its thiol mutants : the inhibitory region enhances binding of troponin_I fragments to troponin_C .
9543552	0	troponin_I	41,51	TNNI2	58,63	troponin I	TNNI2	7136	7136	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of the fast skeletal muscle troponin_I gene -LRB- TNNI2 -RRB- to 11p15 .5 : genes for troponin_I and T are organized in pairs .
1856208	0	troponin_I	127,137	troponin_C	88,98	troponin I	troponin C	100009581(Tax:9986)	100301551(Tax:9986)	Gene	Gene	region|nmod|START_ENTITY END_ENTITY|nmod|region	Cross-linking_of_residue_57 in the regulatory domain of a mutant rabbit skeletal muscle troponin_C to the inhibitory region of troponin_I .
8780504	0	troponin_I	148,158	troponin_C	172,182	troponin I	troponin C	100009581(Tax:9986)	100301551(Tax:9986)	Gene	Gene	fragments|amod|START_ENTITY fragments|nmod|END_ENTITY	Photo-cross-linking of rabbit skeletal troponin_I deletion mutants with troponin_C and its thiol mutants : the inhibitory region enhances binding of troponin_I fragments to troponin_C .
25430424	0	troponin_T1	68,79	TNNT1	81,86	troponin T1	TNNT1	7138	7138	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of a novel nemaline_myopathy-Causing mutation in the troponin_T1 -LRB- TNNT1 -RRB- gene : A case outside of the old order amish .
7958943	0	trp1	84,88	TRP1	41,45	trp1	TRP1	851570(Tax:4932)	851570(Tax:4932)	Gene	Gene	gene|nmod|START_ENTITY gene|compound|END_ENTITY	Characterization of the Candida_albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation .
6172356	0	trypsin-pancreatic_secretory_trypsin_inhibitor	56,102	PSTI	104,108	trypsin-pancreatic secretory trypsin inhibitor	PSTI	6690	6690	Gene	Gene	complexes|amod|START_ENTITY complexes|appos|END_ENTITY	Studies on the interaction of Trasylol -LRB- aprotinin -RRB- with trypsin-pancreatic_secretory_trypsin_inhibitor -LRB- PSTI -RRB- complexes and with alpha_2-macroglobulin-trypsin-PSTI-complexes .
8439623	0	trypsin_inhibitor	38,55	acrosin	14,21	trypsin inhibitor	acrosin	83716	49	Gene	Gene	activity|nmod|START_ENTITY activity|compound|END_ENTITY	Inhibition of acrosin activity with a trypsin_inhibitor blocks human sperm penetration of the zona pellucida .
999042	0	trypsin_inhibitor	36,53	acrosin	12,19	trypsin inhibitor	acrosin	83716	49	Gene	Gene	START_ENTITY|nsubj|Studies Studies|nmod|sperm sperm|compound|END_ENTITY	-LSB- Studies of acrosin and human sperm trypsin_inhibitor activity in human semen .
16534247	0	trypsinogen_1	28,41	Cathepsin_B	0,11	trypsinogen 1	Cathepsin B	5644	1508	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Cathepsin_B activates human trypsinogen_1 but not proelastase 2 or procarboxypeptidase_B .
9279212	0	tryptase	22,30	Lactoferrin	0,11	tryptase	Lactoferrin	443433(Tax:9940)	554321(Tax:9940)	Gene	Gene	inhibitor|compound|START_ENTITY END_ENTITY|appos|inhibitor	Lactoferrin , a potent tryptase inhibitor , abolishes late-phase airway responses in allergic sheep .
22796107	0	tryptophan_hydroxylase-1	77,101	TPH-1	103,108	tryptophan hydroxylase-1	TPH-1	21990(Tax:10090)	21990(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Selective estrogen_receptor-beta -LRB- SERM-beta -RRB- compounds modulate raphe nuclei tryptophan_hydroxylase-1 -LRB- TPH-1 -RRB- mRNA expression and cause antidepressant-like effects in the forced swim test .
16759340	0	tryptophan_hydroxylase-2	30,54	TPH2	56,60	tryptophan hydroxylase-2	TPH2	121278	121278	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of variations in the tryptophan_hydroxylase-2 -LRB- TPH2 -RRB- gene in cocaine_dependence .
17870198	0	tryptophan_hydroxylase_1	4,28	TPH1	30,34	tryptophan hydroxylase 1	TPH1	7166	7166	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The tryptophan_hydroxylase_1 -LRB- TPH1 -RRB- gene and risk of schizophrenia : a moderate-scale case-control study and meta-analysis .
19526457	0	tryptophan_hydroxylase_1	4,28	TPH1	30,34	tryptophan hydroxylase 1	TPH1	7166	7166	Gene	Gene	gene|nummod|START_ENTITY gene|compound|END_ENTITY	The tryptophan_hydroxylase_1 -LRB- TPH1 -RRB- gene , schizophrenia susceptibility , and suicidal behavior : a multi-centre case-control study and meta-analysis .
20052688	0	tryptophan_hydroxylase_1_and_2	48,78	serotonin_transporter	25,46	tryptophan hydroxylase 1 and 2	serotonin transporter	7166;121278	6532	Gene	Gene	expression|amod|START_ENTITY analysis|appos|expression analysis|nmod|END_ENTITY	Simultaneous analysis of serotonin_transporter , tryptophan_hydroxylase_1_and_2 gene expression in the ventral prefrontal cortex of suicide victims .
19763617	0	tryptophan_hydroxylase_2	15,39	TPH2	41,45	tryptophan hydroxylase 2	TPH2	121278	121278	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Involvement of tryptophan_hydroxylase_2 -LRB- TPH2 -RRB- gene polymorphisms in susceptibility to coronary_artery_lesions in Korean children with Kawasaki_disease .
21765945	0	tryptophan_hydroxylase_2	20,44	TPH2	46,50	tryptophan hydroxylase 2	TPH2	467070(Tax:9598)	467070(Tax:9598)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism of the tryptophan_hydroxylase_2 -LRB- TPH2 -RRB- gene is associated with chimpanzee neuroticism .
22361444	0	tryptophan_hydroxylase_2	44,68	TPH2	70,74	tryptophan hydroxylase 2	TPH2	121278	121278	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A detailed association analysis between the tryptophan_hydroxylase_2 -LRB- TPH2 -RRB- gene and autism_spectrum_disorders in a Japanese population .
22721547	0	tryptophan_hydroxylase_2	24,48	TPH2	55,59	tryptophan hydroxylase 2	TPH2	121278	121278	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variants in the tryptophan_hydroxylase_2 gene -LRB- TPH2 -RRB- and depression during and after pregnancy .
15476687	0	tryptophan_hydroxylase_isoform	65,95	TPH2	97,101	tryptophan hydroxylase isoform	TPH2	121278	121278	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphism and haplotype analysis of a novel tryptophan_hydroxylase_isoform -LRB- TPH2 -RRB- gene in suicide victims .
8646895	0	tryptophanyl-tRNA_synthetase	24,52	WARS	59,63	tryptophanyl-tRNA synthetase	WARS	7453	7453	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Assignment of the human tryptophanyl-tRNA_synthetase gene -LRB- WARS -RRB- to chromosome 14q32 .2 -- > q32 .32 .
9699517	0	ts13	99,103	epidermal_growth_factor_receptor	26,58	ts13	epidermal growth factor receptor	7896	1956	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	CCG1/TAF -LRB- II -RRB- 250 regulates epidermal_growth_factor_receptor gene transcription in cell cycle mutant ts13 .
1358794	0	tub	64,67	Ins-2	27,32	tub	Ins-2	22141(Tax:10090)	16334(Tax:10090)	Gene	Gene	Localization|appos|START_ENTITY Localization|nmod|END_ENTITY	Localization of insulin-2 -LRB- Ins-2 -RRB- and the obesity mutant tubby -LRB- tub -RRB- to distinct regions of mouse chromosome 7 .
9477305	0	tub	11,14	rd5	16,19	tub	rd5	22141(Tax:10090)	22141(Tax:10090)	Gene	Gene	mutation|compound|START_ENTITY mutation|appos|END_ENTITY	The murine tub -LRB- rd5 -RRB- mutation is not associated with a primary axonemal_defect .
8180620	0	tubB1	75,80	tubulin	61,68	tubB1	tubulin	100776983	547844(Tax:3847)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Hypocotyl expression and light downregulation of the soybean tubulin gene , tubB1 .
11483369	0	tubby-like_protein_1	58,78	tulp1	80,85	tubby-like protein 1	tulp1	395321(Tax:9031)	395321(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular cloning , expression and regulation of the avian tubby-like_protein_1 -LRB- tulp1 -RRB- gene .
7591959	0	tuberous_sclerosis	20,38	Tsc2	40,44	tuberous sclerosis	Tsc2	24855(Tax:10116)	24855(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allelic loss at the tuberous_sclerosis -LRB- Tsc2 -RRB- gene locus in spontaneous uterine_leiomyosarcomas and pituitary_adenomas in the Eker rat model .
9809973	0	tuberous_sclerosis_1	29,49	TSC1	51,55	tuberous sclerosis 1	TSC1	60445(Tax:10116)	60445(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Hamartin , the product of the tuberous_sclerosis_1 -LRB- TSC1 -RRB- gene , interacts with tuberin and appears to be localized to cytoplasmic vesicles .
10029074	0	tuberous_sclerosis_1	63,83	Tsc1	90,94	tuberous sclerosis 1	Tsc1	7248	7248	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Isolation and characterization of a rat homologue of the human tuberous_sclerosis_1 gene -LRB- Tsc1 -RRB- and analysis of its mutations in rat renal carcinomas .
10732801	0	tuberous_sclerosis_2	42,62	TSC2	64,68	tuberous sclerosis 2	TSC2	7249	7249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation and polymorphism analysis in the tuberous_sclerosis_2 -LRB- TSC2 -RRB- gene .
7558029	0	tuberous_sclerosis_2	28,48	TSC2	50,54	tuberous sclerosis 2	TSC2	7249	7249	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alternative splicing of the tuberous_sclerosis_2 -LRB- TSC2 -RRB- gene in human and mouse tissues .
7972075	0	tuberous_sclerosis_2	93,113	TSC2	115,119	tuberous sclerosis 2	TSC2	24855(Tax:10116)	24855(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Predisposition to renal_carcinoma in the Eker rat is determined by germ-line mutation of the tuberous_sclerosis_2 -LRB- TSC2 -RRB- gene .
12842888	0	tuberous_sclerosis_complex_2	11,39	Rheb	0,4	tuberous sclerosis complex 2	Rheb	7249	6009	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Rheb binds tuberous_sclerosis_complex_2 -LRB- TSC2 -RRB- and promotes S6 kinase activation in a rapamycin - and farnesylation-dependent manner .
17942919	0	tuberous_sclerosis_complex_2	34,62	Rheb	118,122	tuberous sclerosis complex 2	Rheb	22084(Tax:10090)	19744(Tax:10090)	Gene	Gene	cells|amod|START_ENTITY growth|nmod|cells inhibition|nmod|growth associated|nsubjpass|inhibition associated|nmod|END_ENTITY	Selective inhibition of growth of tuberous_sclerosis_complex_2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity .
8180620	0	tubulin	61,68	tubB1	75,80	tubulin	tubB1	547844(Tax:3847)	100776983	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Hypocotyl expression and light downregulation of the soybean tubulin gene , tubB1 .
12446740	0	tubulin-specific_chaperone_E	25,53	Tbce	55,59	tubulin-specific chaperone E	Tbce	70430(Tax:10090)	70430(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Missense mutation in the tubulin-specific_chaperone_E -LRB- Tbce -RRB- gene in the mouse mutant progressive motor_neuronopathy , a model of human motoneuron_disease .
22880023	0	tubulin_cofactor_A	18,36	TBCA	38,42	tubulin cofactor A	TBCA	21371(Tax:10090)	21371(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of tubulin_cofactor_A -LRB- TBCA -RRB- is regulated by a noncoding antisense Tbca RNA during testis maturation .
16303566	0	tubulin_folding_cofactor_B	25,51	Gigaxonin	0,9	tubulin folding cofactor B	Gigaxonin	1155	8139	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Gigaxonin interacts with tubulin_folding_cofactor_B and controls its degradation through the ubiquitin-proteasome pathway .
11054573	0	tubulin_tyrosine_ligase-like_1	30,60	TTLL1	67,72	tubulin tyrosine ligase-like 1	TTLL1	25809	25809	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the human tubulin_tyrosine_ligase-like_1 gene -LRB- TTLL1 -RRB- mapping to 22q13 .1 .
12489194	0	tuftelin	10,18	tuftelin	46,54	tuftelin	tuftelin	7286	7286	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues .
12489194	0	tuftelin	46,54	tuftelin	10,18	tuftelin	tuftelin	7286	7286	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues .
11483369	0	tulp1	80,85	tubby-like_protein_1	58,78	tulp1	tubby-like protein 1	395321(Tax:9031)	395321(Tax:9031)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Molecular cloning , expression and regulation of the avian tubby-like_protein_1 -LRB- tulp1 -RRB- gene .
22517003	0	tumor	105,110	EpCAM	72,77	EpCAM	EpCAM	4072	4072	Gene	Gene	cells|compound|START_ENTITY cells|appos|END_ENTITY	-LSB- Detection and clinical value of epithelial_cellular_adhesion_molecule -LRB- EpCAM -RRB- mRNA positive circulating tumor cells in metastatic breast_cancer -RSB- .
26493689	0	tumor	13,18	TIM-3	41,46	TIM-3	TIM-3	171285(Tax:10090)	171285(Tax:10090)	Gene	Gene	+|compound|START_ENTITY +|compound|END_ENTITY	Apoptosis of tumor infiltrating effector TIM-3 + CD8 + T cells in colon_cancer .
15330186	0	tumor	53,58	VEGF	73,77	COX-2	VEGF	4513	7422	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Survival in small_cell_lung_cancer is independent of tumor expression of VEGF and COX-2 .
22517003	0	tumor	105,110	epithelial_cellular_adhesion_molecule	33,70	EpCAM	epithelial cellular adhesion molecule	4072	4072	Gene	Gene	cells|compound|START_ENTITY cells|amod|END_ENTITY	-LSB- Detection and clinical value of epithelial_cellular_adhesion_molecule -LRB- EpCAM -RRB- mRNA positive circulating tumor cells in metastatic breast_cancer -RSB- .
24229711	0	tumor	94,99	p27	24,27	Pirh2	p27	25898	3429	Gene	Gene	suppressors|compound|START_ENTITY absence|nmod|suppressors tumorigenesis|nmod|absence safeguard|ccomp|tumorigenesis safeguard|nsubj|END_ENTITY	Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors .
16705155	0	tumor	44,49	p53	40,43	SRCAP	p53	10847	7157	Gene	Gene	pathway|compound|START_ENTITY pathway|compound|END_ENTITY	GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation .
21735133	0	tumor-associated_NADH_oxidase	19,48	tNOX	50,54	tumor-associated NADH oxidase	tNOX	10495	10495	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|appos|END_ENTITY	Down-regulation of tumor-associated_NADH_oxidase , tNOX -LRB- ENOX2 -RRB- , enhances capsaicin-induced inhibition of gastric_cancer cell growth .
1780685	0	tumor-associated_trypsin_inhibitor	14,48	CA125	61,66	tumor-associated trypsin inhibitor	CA125	6690	94025	Gene	Gene	Comparison|nmod|START_ENTITY Comparison|nmod|END_ENTITY	Comparison of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- with CA125 as a marker for diagnosis and monitoring of epithelial_ovarian_cancer .
15963628	0	tumor-associated_trypsin_inhibitor	18,52	TATI	54,58	tumor-associated trypsin inhibitor	TATI	6690	6690	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Urinary levels of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- in the detection of transitional cell carcinoma_of_the_urinary_bladder .
1780683	0	tumor-associated_trypsin_inhibitor	14,48	TATI	50,54	tumor-associated trypsin inhibitor	TATI	6690	6690	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- in women with benign and malignant_gynecological_disease .
2717042	0	tumor-associated_trypsin_inhibitor	18,52	TATI	54,58	tumor-associated trypsin inhibitor	TATI	6690	6690	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of tumor-associated_trypsin_inhibitor -LRB- TATI -RRB- in subjects with gastrointestinal_diseases .
15138999	0	tumor-suppressor	67,83	EPB41L3	58,65	tumor-suppressor	EPB41L3	7248	23136	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allele-specific loss of heterozygosity at the DAL-1 / 4.1 B -LRB- EPB41L3 -RRB- tumor-suppressor gene locus in the absence of mutation .
9788631	0	tumor-suppressor	32,48	INK4A	25,30	tumor-suppressor	INK4A	7248	1029	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inactivation of the p16 -LRB- INK4A -RRB- tumor-suppressor gene in pancreatic_duct_lesions : loss of intranuclear expression .
9679752	0	tumor-suppressor	48,64	IRF-1	65,70	tumor-suppressor	IRF-1	7248	3659	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric_cancer .
16324214	0	tumor-suppressor	82,98	NF2	77,80	tumor-suppressor	NF2	7248	4771	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evolution and origin of merlin , the product of the Neurofibromatosis_type_2 -LRB- NF2 -RRB- tumor-suppressor gene .
7829260	0	tumor-suppressor	20,36	NF2	16,19	tumor-suppressor	NF2	7248	4771	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Analysis of the NF2 tumor-suppressor gene and of chromosome 22 deletions in gliomas .
16324214	0	tumor-suppressor	82,98	Neurofibromatosis_type_2	51,75	tumor-suppressor	Neurofibromatosis type 2	7248	4771	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Evolution and origin of merlin , the product of the Neurofibromatosis_type_2 -LRB- NF2 -RRB- tumor-suppressor gene .
22243968	0	tumor-suppressor	48,64	SMAD4	42,47	tumor-suppressor	SMAD4	7248	4089	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	A restricted spectrum of mutations in the SMAD4 tumor-suppressor gene underlies Myhre_syndrome .
8162331	0	tumor-suppressor	5,21	TP53	0,4	tumor-suppressor	TP53	7248	7157	Gene	Gene	gene|amod|START_ENTITY END_ENTITY|dep|gene	TP53 tumor-suppressor gene and human carcinogenesis .
11054685	0	tumor-suppressor	28,44	Von_Hippel-Lindau	4,21	tumor-suppressor	Von Hippel-Lindau	7248	7428	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The Von_Hippel-Lindau -LRB- VHL -RRB- tumor-suppressor gene is not mutated in sporadic human colon_adenocarcinomas .
13679459	0	tumor-suppressor	23,39	p16	4,7	tumor-suppressor	p16	7248	1029	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The p16 -LRB- CDKN2a/INK4a -RRB- tumor-suppressor gene in head_and_neck_squamous_cell_carcinoma : a promoter methylation and protein expression study in 100 cases .
22705216	0	tumor-suppressor	24,40	p16	20,23	tumor-suppressor	p16	7248	1029	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Hypermethylation of p16 tumor-suppressor gene in ameloblastic_carcinoma , ameloblastoma , and dental follicles .
23190892	0	tumor-suppressor	59,75	p16	42,45	tumor-suppressor	p16	7248	1029	Gene	Gene	functions|amod|START_ENTITY uncouple|dobj|functions uncouple|nsubj|mutations mutations|nmod|END_ENTITY	Familial_melanoma-associated mutations in p16 uncouple its tumor-suppressor functions .
9788631	0	tumor-suppressor	32,48	p16	20,23	tumor-suppressor	p16	7248	1029	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Inactivation of the p16 -LRB- INK4A -RRB- tumor-suppressor gene in pancreatic_duct_lesions : loss of intranuclear expression .
17608728	0	tumor-suppressor	173,189	retinoic_acid_receptor-beta	145,172	tumor-suppressor	retinoic acid receptor-beta	7248	5915	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	The DNA-binding epidermal_growth_factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic_acid_receptor-beta tumor-suppressor gene in breast_cancer cells .
20632125	0	tumor-suppressor	28,44	von_Hippel-Lindau	4,21	tumor-suppressor	von Hippel-Lindau	7248	7428	Gene	Gene	gene|amod|START_ENTITY down-regulated|nsubjpass|gene _|ccomp|down-regulated _|nsubj|_ _|amod|END_ENTITY	The von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa .
3141056	0	tumor_growth_inhibitory_factor	13,43	TGIF	45,49	tumor growth inhibitory factor	TGIF	3586	3586	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of tumor_growth_inhibitory_factor -LRB- TGIF -RRB- in human mononuclear cells by OK-432 , a streptococcal preparation .
1381359	0	tumor_necrosis_factor	34,55	A20	93,96	tumor necrosis factor	A20	7124	7128	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Transcriptional activation of the tumor_necrosis_factor alpha-inducible zinc finger protein , A20 , is mediated by kappa B elements .
3260938	0	tumor_necrosis_factor	28,49	C5a	0,3	tumor necrosis factor	C5a	7124	728	Gene	Gene	secretion|nmod|START_ENTITY stimulates|dobj|secretion stimulates|nsubj|END_ENTITY	C5a stimulates secretion of tumor_necrosis_factor from human mononuclear cells in vitro .
8614033	0	tumor_necrosis_factor	70,91	CD14	8,12	tumor necrosis factor	CD14	21926(Tax:10090)	12475(Tax:10090)	Gene	Gene	response|compound|START_ENTITY Role|nmod|response Role|nmod|END_ENTITY	Role of CD14 in hemorrhagic_shock-induced alterations of the monocyte tumor_necrosis_factor response to endotoxin .
24339053	0	tumor_necrosis_factor	18,39	CD25	145,149	tumor necrosis factor	CD25	21926(Tax:10090)	16184(Tax:10090)	Gene	Gene	START_ENTITY|ccomp|contributes contributes|xcomp|inhibition inhibition|nmod|pulmonary_fibrosis pulmonary_fibrosis|nmod|+ +|compound|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
10438843	0	tumor_necrosis_factor	184,205	CD4	131,134	tumor necrosis factor	CD4	7124	920	Gene	Gene	role|nmod|START_ENTITY thymocytes|dep|role thymocytes|amod|human_immunodeficiency_virus human_immunodeficiency_virus|nmod|CD8 CD8|compound|END_ENTITY	Thymocyte-thymic epithelial cell interaction leads to high-level replication of human_immunodeficiency_virus exclusively in mature CD4 -LRB- + -RRB- CD8 -LRB- - -RRB- CD3 -LRB- + -RRB- thymocytes : a critical role for tumor_necrosis_factor and interleukin-7 .
10562322	0	tumor_necrosis_factor	22,43	CD4	148,151	tumor necrosis factor	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	required|nsubjpass|START_ENTITY required|nmod|gene gene|acl:relcl|T T|nsubj|mice mice|nmod|transfer transfer|nmod|CD45RB CD45RB|compound|END_ENTITY	Nonlymphocyte-derived tumor_necrosis_factor is required for induction of colitis in recombination activating gene -LRB- RAG -RRB- 2 -LRB- - / - -RRB- mice upon transfer of CD4 -LRB- + -RRB- CD45RB -LRB- hi -RRB- T cells .
11037976	0	tumor_necrosis_factor	8,29	CD4	142,145	tumor necrosis factor	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	prevents|nsubj|START_ENTITY prevents|ccomp|bacillus bacillus|dobj|infection infection|nmod|mice mice|compound|END_ENTITY	A novel tumor_necrosis_factor -LRB- TNF -RRB- mimetic peptide prevents recrudescence of Mycobacterium_bovis bacillus Calmette-Guerin -LRB- BCG -RRB- infection in CD4 + T cell-depleted mice .
23494522	0	tumor_necrosis_factor	112,133	CD4	52,55	tumor necrosis factor	CD4	7124	920	Gene	Gene	gradients|compound|START_ENTITY follow|dobj|gradients enables|xcomp|follow enables|nsubj|expression expression|nmod|cells cells|nummod|END_ENTITY	Tumor_necrosis_factor receptor type I expression of CD4 + T cells in rheumatoid_arthritis enables them to follow tumor_necrosis_factor gradients into the rheumatoid synovium .
24339053	0	tumor_necrosis_factor	18,39	CD4	140,143	tumor necrosis factor	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|ccomp|contributes contributes|xcomp|inhibition inhibition|nmod|pulmonary_fibrosis pulmonary_fibrosis|nmod|+ +|compound|END_ENTITY	Locally instilled tumor_necrosis_factor a antisense oligonucleotide contributes to inhibition of TH 2-driven pulmonary_fibrosis via induced CD4 + CD25 + Foxp3 + regulatory T cells .
1804390	0	tumor_necrosis_factor	91,112	CPT-11	46,52	tumor necrosis factor	CPT-11	7124	963084(Tax:115711)	Gene	Gene	Augmentation|nmod|START_ENTITY Augmentation|nmod|activity activity|nmod|END_ENTITY	Augmentation of antiproliferative activity of CPT-11 , a new derivative of camptothecin , by tumor_necrosis_factor against proliferation of gynecologic_tumor cell lines .
8952522	0	tumor_necrosis_factor	25,46	Cardiotrophin-1	0,15	tumor necrosis factor	Cardiotrophin-1	21926(Tax:10090)	13019(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Cardiotrophin-1 inhibits tumor_necrosis_factor production in the heart and serum of lipopolysaccharide-treated mice and in vitro in mouse blood cells .
8529123	0	tumor_necrosis_factor	58,79	Ciliary_neurotrophic_factor	0,27	tumor necrosis factor	Ciliary neurotrophic factor	21926(Tax:10090)	12803(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Ciliary_neurotrophic_factor inhibits brain and peripheral tumor_necrosis_factor production and , when coadministered with its soluble receptor , protects mice from lipopolysaccharide toxicity .
1730654	0	tumor_necrosis_factor	32,53	Egr-1	18,23	tumor necrosis factor	Egr-1	7124	1958	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|gene gene|compound|END_ENTITY	Regulation of the Egr-1 gene by tumor_necrosis_factor and interferons in primary human fibroblasts .
15548538	0	tumor_necrosis_factor	67,88	FXR1P	26,31	tumor necrosis factor	FXR1P	21926(Tax:10090)	14359(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor_necrosis_factor expression at the post-transcriptional level .
15627641	0	tumor_necrosis_factor	48,69	Granulocyte_colony-stimulating_factor	0,37	tumor necrosis factor	Granulocyte colony-stimulating factor	7124	1440	Gene	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor decreases tumor_necrosis_factor production in whole blood : role of interleukin-10 and prostaglandin_E -LRB- 2 -RRB- .
9185715	0	tumor_necrosis_factor	52,73	ICAM-1	24,30	tumor necrosis factor	ICAM-1	7124	3383	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Decreased expression of ICAM-1 and its induction by tumor_necrosis_factor on breast-cancer cells in vitro .
9414135	0	tumor_necrosis_factor	11,32	ICAM-1	55,61	tumor necrosis factor	ICAM-1	7124	3383	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|expression expression|compound|END_ENTITY	Effects of tumor_necrosis_factor and pentoxifylline on ICAM-1 expression on human polymorphonuclear granulocytes .
17725274	0	tumor_necrosis_factor	86,107	IL-6	136,140	tumor necrosis factor	IL-6	7124	3569	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|interleukin_6 interleukin_6|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
12423273	0	tumor_necrosis_factor	58,79	Interferon-gamma	0,16	tumor necrosis factor	Interferon-gamma	7124	3458	Gene	Gene	receptors|compound|START_ENTITY releasing|dobj|receptors regulates|advcl|releasing regulates|nsubj|END_ENTITY	Interferon-gamma regulates apoptosis by releasing soluble tumor_necrosis_factor receptors in a gastric epithelial cell line .
1330686	0	tumor_necrosis_factor	67,88	Interferon-gamma	0,16	tumor necrosis factor	Interferon-gamma	7124	3458	Gene	Gene	receptors|compound|START_ENTITY types|nmod|receptors expression|nmod|types induces|dobj|expression induces|nsubj|END_ENTITY	Interferon-gamma induces cell surface expression for both types of tumor_necrosis_factor receptors .
3005410	0	tumor_necrosis_factor	63,84	Interferon-gamma	0,16	tumor necrosis factor	Interferon-gamma	7124	3458	Gene	Gene	receptors|nmod|START_ENTITY expression|nmod|receptors enhances|dobj|expression enhances|nsubj|END_ENTITY	Interferon-gamma enhances expression of cellular receptors for tumor_necrosis_factor .
3117888	2	tumor_necrosis_factor	90,111	Interferon-gamma	64,80	tumor necrosis factor	Interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	requires|dobj|START_ENTITY requires|nsubj|END_ENTITY	Interferon-gamma requires tumor_necrosis_factor to restrain tumor cell growth in peritoneal cell cultures from tumor-dormant mice .
11254592	0	tumor_necrosis_factor	83,104	Interleukin-10	0,14	tumor necrosis factor	Interleukin-10	7124	3586	Gene	Gene	down-modulation|compound|START_ENTITY replication|nmod|down-modulation Coxiella_burnetii|acl|replication Coxiella_burnetii|compound|END_ENTITY	Interleukin-10 stimulates Coxiella_burnetii replication in human monocytes through tumor_necrosis_factor down-modulation : role in microbicidal defect of Q_fever .
8646564	0	tumor_necrosis_factor	51,72	Interleukin-10	0,14	tumor necrosis factor	Interleukin-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	inhibits|dobj|START_ENTITY inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits lipopolysaccharide-induced tumor_necrosis_factor and interleukin-1 beta production in the brain without affecting the activation of the hypothalamus-pituitary-adrenal_axis .
8648229	0	tumor_necrosis_factor	27,48	Interleukin-10	0,14	tumor necrosis factor	Interleukin-10	7124	3586	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Interleukin-10 and soluble tumor_necrosis_factor receptors in cerebrospinal fluid of children with bacterial_meningitis .
8699123	0	tumor_necrosis_factor	46,67	Interleukin-10	0,14	tumor necrosis factor	Interleukin-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-10 inhibits interleukin-2-induced tumor_necrosis_factor production but does not reduce toxicity in C3H/HeN mice .
1524837	0	tumor_necrosis_factor	51,72	Interleukin-6	0,13	tumor necrosis factor	Interleukin-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	lethality|nmod|START_ENTITY mice|amod|lethality marker|nmod|mice marker|nsubj|END_ENTITY	Interleukin-6 is a better marker of lethality than tumor_necrosis_factor in endotoxin treated mice .
1653625	0	tumor_necrosis_factor	41,62	Interleukin-6	0,13	tumor necrosis factor	Interleukin-6	7124	3569	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors enhances|dobj|expression enhances|nsubj|END_ENTITY	Interleukin-6 enhances the expression of tumor_necrosis_factor receptors on hepatoma cells and hepatocytes .
2192263	0	tumor_necrosis_factor	27,48	Interleukin-6	0,13	tumor necrosis factor	Interleukin-6	7124	3569	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Interleukin-6 induction by tumor_necrosis_factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence .
8274730	0	tumor_necrosis_factor	117,138	Interleukin-6	0,13	tumor necrosis factor	Interleukin-6	7124	3569	Gene	Gene	p55|compound|START_ENTITY circulating|dobj|p55 induction|acl|circulating END_ENTITY|dep|induction	Interleukin-6 -LRB- IL-6 -RRB- as an anti-inflammatory cytokine : induction of circulating IL-1_receptor_antagonist and soluble tumor_necrosis_factor receptor p55 .
1937586	0	tumor_necrosis_factor	22,43	Interleukin_2	0,13	tumor necrosis factor	Interleukin 2	21926(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_2 induces tumor_necrosis_factor gene expression in vivo .
12417721	0	tumor_necrosis_factor	108,129	Jun_kinase	86,96	tumor necrosis factor	Jun kinase	7124	5601	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	The p65/RelA subunit of NF-kappaB suppresses the sustained , antiapoptotic activity of Jun_kinase induced by tumor_necrosis_factor .
14966426	0	tumor_necrosis_factor	46,67	Macrophage_colony-stimulating_factor	0,36	tumor necrosis factor	Macrophage colony-stimulating factor	21926(Tax:10090)	12977(Tax:10090)	Gene	Gene	production|compound|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Macrophage_colony-stimulating_factor inhibits tumor_necrosis_factor production and prolongs skin graft survival .
11000208	0	tumor_necrosis_factor	82,103	Nef	36,39	tumor necrosis factor	Nef	7124	6285	Gene	Gene	expression|nmod|START_ENTITY mediates|dobj|expression mediates|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 Nef mediates sustained membrane expression of tumor_necrosis_factor and the related cytokine LIGHT on activated T cells .
1310388	0	tumor_necrosis_factor	62,83	P60	132,135	tumor necrosis factor	P60	7124	7984	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|forms forms|nmod|END_ENTITY	Inhibition of ligand binding and antiproliferative effects of tumor_necrosis_factor and lymphotoxin by soluble forms of recombinant P60 and P80 receptors .
2121330	0	tumor_necrosis_factor	49,70	Phospholipase_A2	0,16	tumor necrosis factor	Phospholipase A2	7124	151056	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|amod|END_ENTITY	Phospholipase_A2 activation and autoinduction of tumor_necrosis_factor gene expression by tumor_necrosis_factor .
2121330	0	tumor_necrosis_factor	90,111	Phospholipase_A2	0,16	tumor necrosis factor	Phospholipase A2	7124	151056	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Phospholipase_A2 activation and autoinduction of tumor_necrosis_factor gene expression by tumor_necrosis_factor .
8824249	0	tumor_necrosis_factor	57,78	Plasminogen_activator_inhibitor_type_2	0,38	tumor necrosis factor	Plasminogen activator inhibitor type 2	7124	5055	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Plasminogen_activator_inhibitor_type_2 gene induction by tumor_necrosis_factor and phorbol_ester involves transcriptional and post-transcriptional events .
24338472	0	tumor_necrosis_factor	66,87	Polo-like_kinase_2	0,18	tumor necrosis factor	Polo-like kinase 2	7124	10769	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Polo-like_kinase_2 , a novel ADAM17 signaling component , regulates tumor_necrosis_factor a ectodomain shedding .
12032139	0	tumor_necrosis_factor	89,110	Suppressor_of_cytokine_signaling-1	0,34	tumor necrosis factor	Suppressor of cytokine signaling-1	7124	8651	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Suppressor_of_cytokine_signaling-1 regulates the sensitivity of pancreatic beta cells to tumor_necrosis_factor .
10100747	0	tumor_necrosis_factor	9,30	THP-1	93,98	tumor necrosis factor	THP-1	7124	2736	Gene	Gene	inhibitor|compound|START_ENTITY released|nsubj|inhibitor released|xcomp|END_ENTITY	A 63 kDa tumor_necrosis_factor inhibitor released from a human monocytic_leukemia cell line , THP-1 .
1894940	0	tumor_necrosis_factor	26,47	THP-1	53,58	tumor necrosis factor	THP-1	7124	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Differences in release of tumor_necrosis_factor from THP-1 cells stimulated by filtrates of antibiotic-killed Escherichia_coli .
2228228	0	tumor_necrosis_factor	51,72	THP-1	99,104	tumor necrosis factor	THP-1	7124	2736	Gene	Gene	START_ENTITY|nmod|line line|appos|END_ENTITY	Mycoplasmas induce transcription and production of tumor_necrosis_factor in a monocytic cell line , THP-1 , by a protein kinase C-independent pathway .
7806621	0	tumor_necrosis_factor	11,32	THP-1	122,127	tumor necrosis factor	THP-1	7124	2736	Gene	Gene	Effect|nmod|START_ENTITY _|nsubj|Effect _|dobj|expression expression|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Effect of tumor_necrosis_factor and interferon-gamma on platelet-derived growth factor -LRB- PDGF -RRB- _ A_and_B gene expression in THP-1 monocytic cells -RSB- .
8660816	0	tumor_necrosis_factor	31,52	THP-1	89,94	tumor necrosis factor	THP-1	7124	2736	Gene	Gene	receptor|compound|START_ENTITY regulation|nmod|receptor release|nsubj|regulation release|nmod|cells cells|compound|END_ENTITY	Prostaglandin-E2 regulation of tumor_necrosis_factor receptor release in human monocytic THP-1 cells .
11041560	0	tumor_necrosis_factor	12,33	TNF	35,38	tumor necrosis factor	TNF	103694380	103694380	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of tumor_necrosis_factor -LRB- TNF -RRB- in the febrile and metabolic responses of rats to intraperitoneal injection of a high dose of lipopolysaccharide .
11181695	0	tumor_necrosis_factor	72,93	TNF	111,114	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	START_ENTITY|nmod|level level|compound|END_ENTITY	Uncoupling the proinflammatory from the immunosuppressive properties of tumor_necrosis_factor -LRB- TNF -RRB- at the p55 TNF receptor level : implications for pathogenesis and therapy of autoimmune_demyelination .
12890427	1	tumor_necrosis_factor	75,96	TNF	109,112	tumor necrosis factor	TNF	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Modulation of tumor_necrosis_factor and soluble TNF receptors .
1330568	0	tumor_necrosis_factor	87,108	TNF	110,113	tumor necrosis factor	TNF	7124	7124	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Involvement of an Asn/Val cleavage site in the production of a soluble form of a human tumor_necrosis_factor -LRB- TNF -RRB- receptor .
15381183	0	tumor_necrosis_factor	20,41	TNF	43,46	tumor necrosis factor	TNF	7124	7124	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of different tumor_necrosis_factor -LRB- TNF -RRB- reactive agents on reverse signaling of membrane integrated TNF in monocytes .
15759114	0	tumor_necrosis_factor	8,29	TNF	31,34	tumor necrosis factor	TNF	554167(Tax:7955)	554167(Tax:7955)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A novel tumor_necrosis_factor -LRB- TNF -RRB- gene present in tandem with theTNF-alpha gene on the same chromosome in teleosts .
15902922	0	tumor_necrosis_factor	12,33	TNF	35,38	tumor necrosis factor	TNF	7124	7124	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relation of tumor_necrosis_factor -LRB- TNF -RRB- gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers .
16093436	0	tumor_necrosis_factor	82,103	TNF	131,134	tumor necrosis factor	TNF	7124	7124	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	The immunocytokine scFv23/TNF sensitizes HER-2 / neu-overexpressing SKBR-3 cells to tumor_necrosis_factor -LRB- TNF -RRB- via up-regulation of TNF receptor-1 .
16385350	0	tumor_necrosis_factor	32,53	TNF	55,58	tumor necrosis factor	TNF	7124	7124	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	-LSB- Differences in pharmacology of tumor_necrosis_factor -LRB- TNF -RRB- antagonists -RSB- .
20012512	0	tumor_necrosis_factor	20,41	TNF	43,46	tumor necrosis factor	TNF	7124	7124	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Delayed addition of tumor_necrosis_factor -LRB- TNF -RRB- antagonists inhibits the generation of CD11c + dendritic cells derived from CD34 + cells exposed to TNF-alpha .
20038584	0	tumor_necrosis_factor	9,30	TNF	65,68	tumor necrosis factor	TNF	7124	7124	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|processing processing|nmod|END_ENTITY	Membrane tumor_necrosis_factor -LRB- TNF -RRB- induces p100 processing via TNF receptor-2 -LRB- TNFR2 -RRB- .
20712570	0	tumor_necrosis_factor	17,38	TNF	40,43	tumor necrosis factor	TNF	7124	7124	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The dual role of tumor_necrosis_factor -LRB- TNF -RRB- in cancer biology .
2280608	0	tumor_necrosis_factor	22,43	TNF	45,48	tumor necrosis factor	TNF	7124	7124	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A regulatory role for tumor_necrosis_factor -LRB- TNF -RRB- in ML-1 human myeloblastic_leukemia cell maturation .
24453410	0	tumor_necrosis_factor	13,34	TNF	36,39	tumor necrosis factor	TNF	7124	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of tumor_necrosis_factor -LRB- TNF -RRB- release from subtypes of T cells by agonists of proteinase activated receptors .
25985765	0	tumor_necrosis_factor	71,92	TNF	94,97	tumor necrosis factor	TNF	7124	7124	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	New strategies to address the pharmacodynamics and pharmacokinetics of tumor_necrosis_factor -LRB- TNF -RRB- inhibitors : A systematic analysis .
2703526	0	tumor_necrosis_factor	10,31	TNF	33,36	tumor necrosis factor	TNF	103694380	103694380	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of tumor_necrosis_factor -LRB- TNF -RRB- on lipid metabolism in the diabetic rat .
2840563	0	tumor_necrosis_factor	11,32	TNF	34,37	tumor necrosis factor	TNF	103694380	103694380	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of tumor_necrosis_factor -LRB- TNF -RRB- on lipolytic activities of rat heart .
2884771	0	tumor_necrosis_factor	11,32	TNF	34,37	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of tumor_necrosis_factor -LRB- TNF -RRB- on transplanted tumors induced by methylcholanthrene in mice .
3099988	0	tumor_necrosis_factor	22,43	TNF	45,48	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- Protective effect of tumor_necrosis_factor -LRB- TNF -RRB- obtained by genetic recombination against experimental bacterial_or_fungal_infection -RSB- .
3117378	0	tumor_necrosis_factor	14,35	TNF	37,40	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
3192948	0	tumor_necrosis_factor	125,146	TNF	148,151	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY activity|appos|END_ENTITY	A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor_necrosis_factor -LRB- TNF -RRB- activity .
3710767	0	tumor_necrosis_factor	11,32	TNF	34,37	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of tumor_necrosis_factor -LRB- TNF -RRB- into mouse peritoneal fluids by OK-432 , a streptococcal preparation .
6481965	0	tumor_necrosis_factor	14,35	TNF	37,40	tumor necrosis factor	TNF	7124	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	-LSB- Induction of tumor_necrosis_factor -LRB- TNF -RRB- by OK-432 -RSB- .
8088324	0	tumor_necrosis_factor	80,101	TNF	103,106	tumor necrosis factor	TNF	7124	7124	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Control of established experimental allergic_encephalomyelitis by inhibition of tumor_necrosis_factor -LRB- TNF -RRB- activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins .
8205115	2	tumor_necrosis_factor	99,120	TNF	122,125	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Increment of tumor_necrosis_factor -LRB- TNF -RRB- activity in mouse sera by carboxamide-methylated light chain .
8319779	0	tumor_necrosis_factor	21,42	TNF	97,100	tumor necrosis factor	TNF	7124	7124	Gene	Gene	Induction|nmod|START_ENTITY END_ENTITY|nsubj|Induction	Induction of surface tumor_necrosis_factor -LRB- TNF -RRB- expression and possible facilitation of surface TNF release from human monocytic cells by granulocyte-macrophage_colony-stimulating_factor or gamma interferon in combination with 1,25-dihydroxyvitamin _ D3 .
8357820	0	tumor_necrosis_factor	35,56	TNF	30,33	tumor necrosis factor	TNF	7124	7124	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	In vitro cytostatic effect of TNF -LRB- tumor_necrosis_factor -RRB- entrapped in immunoliposomes on cells normally insensitive to TNF .
8574755	0	tumor_necrosis_factor	35,56	TNF	58,61	tumor necrosis factor	TNF	100009088(Tax:9986)	100009088(Tax:9986)	Gene	Gene	response|amod|START_ENTITY response|appos|END_ENTITY	Alterations in alveolar macrophage tumor_necrosis_factor -LRB- TNF -RRB- response following hemorrhagic_shock .
8912851	0	tumor_necrosis_factor	69,90	TNF	92,95	tumor necrosis factor	TNF	7124	7124	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor_necrosis_factor -LRB- TNF -RRB- gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells .
9101449	0	tumor_necrosis_factor	20,41	TNF	43,46	tumor necrosis factor	TNF	103694380	103694380	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	The significance of tumor_necrosis_factor -LRB- TNF -RRB- levels for rejection of joint allograft .
9199176	0	tumor_necrosis_factor	68,89	TNF	91,94	tumor necrosis factor	TNF	7124	7124	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Induced expression of trimerized intracellular domains of the human tumor_necrosis_factor -LRB- TNF -RRB- p55 receptor elicits TNF effects .
9876493	0	tumor_necrosis_factor	15,36	TNF	38,41	tumor necrosis factor	TNF	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|appos|END_ENTITY	-LSB- Production of tumor_necrosis_factor -LRB- TNF -RRB- by macrophages and T-lymphocytes of rodents as affected by acute gamma-irradiation -RSB- .
1453299	0	tumor_necrosis_factor	148,169	TNF-alpha	171,180	tumor necrosis factor	TNF-alpha	7124	7124	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Human choriogonadotropin -LRB- hCG -RRB- and placental_lactogen -LRB- hPL -RRB- inhibit interleukin-2 -LRB- IL-2 -RRB- and increase interleukin-1_beta -LRB- IL-1_beta -RRB- , -6 -LRB- IL-6 -RRB- and tumor_necrosis_factor -LRB- TNF-alpha -RRB- expression in monocyte cell cultures .
15230148	0	tumor_necrosis_factor	17,38	TNF-alpha	40,49	tumor necrosis factor	TNF-alpha	7124	7124	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	-LSB- Significance of tumor_necrosis_factor -LRB- TNF-alpha -RRB- in rheumatoid_arthritis -RSB- .
1666506	0	tumor_necrosis_factor	14,35	TNF-alpha	37,46	tumor necrosis factor	TNF-alpha	7124	7124	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of tumor_necrosis_factor -LRB- TNF-alpha -RRB- on calcium -LRB- Ca2 + -RRB- level .
1768744	1	tumor_necrosis_factor	60,81	TNF-alpha	83,92	tumor necrosis factor	TNF-alpha	7124	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of tumor_necrosis_factor -LRB- TNF-alpha -RRB- on human leucocytes .
9391689	0	tumor_necrosis_factor	18,39	TNFR	74,78	tumor necrosis factor	TNFR	7124	7132	Gene	Gene	receptor|compound|START_ENTITY Fc|nsubj|receptor Fc|dobj|protein protein|appos|END_ENTITY	Recombinant human tumor_necrosis_factor receptor -LRB- p75 -RRB- Fc fusion protein -LRB- TNFR : Fc -RRB- in rheumatoid_arthritis .
9684796	0	tumor_necrosis_factor	12,33	TNFR	63,67	tumor necrosis factor	TNFR	7124	7132	Gene	Gene	protein|compound|START_ENTITY protein|appos|END_ENTITY	Recombinant tumor_necrosis_factor receptor p75 fusion protein -LRB- TNFR : Fc -RRB- alters endotoxin-induced activation of the kinin , fibrinolytic , and coagulation systems in normal humans .
15906094	0	tumor_necrosis_factor	54,75	TNFR2	86,91	tumor necrosis factor	TNFR2	7124	7133	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Association tests of interleukin-6 -LRB- IL-6 -RRB- and type II tumor_necrosis_factor receptor -LRB- TNFR2 -RRB- genes with bone_mineral_density in Caucasians using a re-sampling approach .
18056447	0	tumor_necrosis_factor	36,57	Traf1	0,5	tumor necrosis factor	Traf1	7124	7185	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Traf1 induction and protection from tumor_necrosis_factor by nuclear factor-kappaB p65 is independent of serine 536 phosphorylation .
17725274	0	tumor_necrosis_factor	86,107	VEGF	79,83	tumor necrosis factor	VEGF	7124	7422	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
8806891	0	tumor_necrosis_factor	11,32	angiotensin_II	82,96	tumor necrosis factor	angiotensin II	103694380	24179(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY induced|nsubj|Effects induced|nmod|END_ENTITY	Effects of tumor_necrosis_factor and interleukin-1 on the constriction induced by angiotensin_II in rat aorta .
8208546	0	tumor_necrosis_factor	90,111	bcl-2	126,131	tumor necrosis factor	bcl-2	21926(Tax:10090)	12043(Tax:10090)	Gene	Gene	fibroblasts|nmod|START_ENTITY sensitivity|nmod|fibroblasts sensitivity|dep|induction induction|nmod|c-myc c-myc|amod|END_ENTITY	Differential sensitivity of normal and Ha-ras-transformed C3H_mouse embryo fibroblasts to tumor_necrosis_factor : induction of bcl-2 , c-myc , and manganese_superoxide dismutase in resistant cells .
2244888	0	tumor_necrosis_factor	10,31	cachectin	32,41	tumor necrosis factor	cachectin	7124	7124	Gene	Gene	Effect|nmod|START_ENTITY Effect|dep|END_ENTITY	Effect of tumor_necrosis_factor / cachectin on the activity of the low_density_lipoprotein_receptor on human skin fibroblasts .
2307938	1	tumor_necrosis_factor	69,90	cachectin	91,100	tumor necrosis factor	cachectin	7124	7124	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Cell surface expression of tumor_necrosis_factor / cachectin by activated normal human T cells .
2785120	0	tumor_necrosis_factor	12,33	cachectin	34,43	tumor necrosis factor	cachectin	103694380	24835(Tax:10116)	Gene	Gene	Infusion|nmod|START_ENTITY Infusion|parataxis|promotes promotes|nsubj|END_ENTITY	Infusion of tumor_necrosis_factor / cachectin promotes muscle catabolism in the rat .
3132919	0	tumor_necrosis_factor	14,35	cachectin	36,45	tumor necrosis factor	cachectin	103694380	24835(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|dep|END_ENTITY	The effect of tumor_necrosis_factor / cachectin on follicle-stimulating hormone-induced aromatase activity in cultured rat granulosa cells .
3202418	0	tumor_necrosis_factor	31,52	cachectin	53,62	tumor necrosis factor	cachectin	7124	7124	Gene	Gene	expression|nmod|START_ENTITY expression|dep|gene gene|compound|END_ENTITY	Differential expression of the tumor_necrosis_factor / cachectin gene by blood and lung mononuclear phagocytes .
3263462	0	tumor_necrosis_factor	14,35	cachectin	36,45	tumor necrosis factor	cachectin	7124	7124	Gene	Gene	Production|nmod|START_ENTITY Production|dep|END_ENTITY	Production of tumor_necrosis_factor / cachectin by human B cell lines and tonsillar B cells .
17122196	0	tumor_necrosis_factor	137,158	connexin40	18,28	tumor necrosis factor	connexin40	21926(Tax:10090)	14613(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of connexin40 and increased prevalence of atrial_arrhythmias in transgenic_mice with cardiac-restricted overexpression of tumor_necrosis_factor .
8970973	0	tumor_necrosis_factor	101,122	cytosolic_phospholipase_A2	16,42	tumor necrosis factor	cytosolic phospholipase A2	7124	5321	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|activity activity|nmod|END_ENTITY	The activity of cytosolic_phospholipase_A2 is required for the lysis of adenovirus-infected cells by tumor_necrosis_factor .
7706752	0	tumor_necrosis_factor	94,115	early_growth_response_1	51,74	tumor necrosis factor	early growth response 1	7124	1958	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Activation of serine/threonine protein kinases and early_growth_response_1 gene expression by tumor_necrosis_factor in human myeloid_leukemia cells .
1966932	0	tumor_necrosis_factor	117,138	granulocyte-macrophage_colony-stimulating_factor	24,72	tumor necrosis factor	granulocyte-macrophage colony-stimulating factor	7124	1437	Gene	Gene	production|compound|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Differential effects of granulocyte-macrophage_colony-stimulating_factor and macrophage_colony-stimulating_factor on tumor_necrosis_factor and interleukin-1 production in human monocytes .
7691787	0	tumor_necrosis_factor	47,68	granulocyte_colony-stimulating_factor	107,144	tumor necrosis factor	granulocyte colony-stimulating factor	7124	1440	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Enhanced antitumor effect of recombinant human tumor_necrosis_factor in combination with recombinant human granulocyte_colony-stimulating_factor in BALB/c mice .
2332411	0	tumor_necrosis_factor	21,42	hormone_sensitive_lipase	65,89	tumor necrosis factor	hormone sensitive lipase	7124	3991	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|nmod|END_ENTITY	Inhibitory effect of tumor_necrosis_factor on gene expression of hormone_sensitive_lipase in 3T3-L1 adipocytes .
10374812	0	tumor_necrosis_factor	61,82	interferon-gamma	20,36	tumor necrosis factor	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|compound|START_ENTITY effects|nmod|production effects|nmod|END_ENTITY	Opposite effects of interferon-gamma and prostaglandin_E2 on tumor_necrosis_factor and interleukin-10 production in microglia : a regulatory loop controlling microglia pro- and anti-inflammatory activities .
1790143	0	tumor_necrosis_factor	34,55	interferon-gamma	94,110	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	evaluation|nmod|START_ENTITY given|nsubj|evaluation given|nmod|END_ENTITY	Phase I evaluation of recombinant tumor_necrosis_factor given in combination with recombinant interferon-gamma .
2121882	0	tumor_necrosis_factor	88,109	interferon-gamma	140,156	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	encoding|nmod|START_ENTITY encoding|nmod|END_ENTITY	Gene regulation in macrophage activation : differential regulation of genes encoding for tumor_necrosis_factor , interleukin-1 , JE , and KC by interferon-gamma and lipopolysaccharide .
2497979	0	tumor_necrosis_factor	27,48	interferon-gamma	79,95	tumor necrosis factor	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|mice mice|nmod|END_ENTITY	Induction of an endogenous tumor_necrosis_factor in mice by murine recombinant interferon-gamma combined with a lipid_A subunit analog -LRB- GLA-60 -RRB- of low toxicity .
3005411	0	tumor_necrosis_factor	30,51	interferon-gamma	65,81	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	receptors|compound|START_ENTITY synthesis|nmod|receptors Induction|nmod|synthesis Induction|nmod|END_ENTITY	Induction of the synthesis of tumor_necrosis_factor receptors by interferon-gamma .
3108017	0	tumor_necrosis_factor	45,66	interferon-gamma	82,98	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	caused|nmod|START_ENTITY fragmentation|acl|caused enhanced|nsubjpass|fragmentation enhanced|nmod|END_ENTITY	DNA fragmentation and cytotoxicity caused by tumor_necrosis_factor is enhanced by interferon-gamma .
3112245	0	tumor_necrosis_factor	64,85	interferon-gamma	12,28	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Recombinant interferon-gamma stimulates the production of human tumor_necrosis_factor in vitro .
3117378	0	tumor_necrosis_factor	14,35	interferon-gamma	54,70	tumor necrosis factor	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|dep|END_ENTITY	Regulation of tumor_necrosis_factor -LRB- TNF -RRB- expression : interferon-gamma enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages .
3121361	0	tumor_necrosis_factor	16,37	interferon-gamma	89,105	tumor necrosis factor	interferon-gamma	103694380	25712(Tax:10116)	Gene	Gene	Cytotoxicity|nmod|START_ENTITY Cytotoxicity|nmod|END_ENTITY	Cytotoxicity of tumor_necrosis_factor for thyroid epithelial cells and its regulation by interferon-gamma .
3121562	0	tumor_necrosis_factor	100,121	interferon-gamma	147,163	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	lines|nmod|START_ENTITY and/or|nsubj|lines and/or|dobj|END_ENTITY	In vitro growth inhibition of cisplatin-resistant human lung_cancer cell lines by recombinant human tumor_necrosis_factor and/or recombinant human interferon-gamma by virtue of collateral sensitivity .
3131488	0	tumor_necrosis_factor	56,77	interferon-gamma	109,125	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	activity|nmod|START_ENTITY Augmentation|nmod|activity Augmentation|nmod|END_ENTITY	Augmentation of cytotoxic activity of recombinant human tumor_necrosis_factor -LRB- rHu-TNF -RRB- by recombinant human interferon-gamma -LRB- rHu-IFN-gamma -RRB- .
3137565	0	tumor_necrosis_factor	23,44	interferon-gamma	68,84	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	START_ENTITY|nmod|influence influence|nmod|amplifies amplifies|amod|END_ENTITY	Autocrine secretion of tumor_necrosis_factor under the influence of interferon-gamma amplifies HLA-DR gene induction in human monocytes .
8847144	0	tumor_necrosis_factor	23,44	interferon-gamma	65,81	tumor necrosis factor	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Anti-tumor activity of tumor_necrosis_factor in combination with interferon-gamma is not affected by prior tolerization .
9459614	0	tumor_necrosis_factor	61,82	interferon-gamma	96,112	tumor necrosis factor	interferon-gamma	7124	3458	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors expression|nmod|END_ENTITY	Regulation of expression of transmembrane and soluble 75 kDa tumor_necrosis_factor receptors by interferon-gamma and granulocyte-macrophage_colony-stimulating_factor involves transcriptional activation .
17218947	0	tumor_necrosis_factor	88,109	interferon_gamma	110,126	tumor necrosis factor	interferon gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	therapy|amod|START_ENTITY therapy|compound|END_ENTITY	The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor_necrosis_factor / interferon_gamma antitumor therapy .
15627641	0	tumor_necrosis_factor	48,69	interleukin-10	105,119	tumor necrosis factor	interleukin-10	7124	3586	Gene	Gene	production|compound|START_ENTITY decreases|dobj|production decreases|parataxis|role role|nmod|END_ENTITY	Granulocyte_colony-stimulating_factor decreases tumor_necrosis_factor production in whole blood : role of interleukin-10 and prostaglandin_E -LRB- 2 -RRB- .
8764378	0	tumor_necrosis_factor	47,68	interleukin-10	20,34	tumor necrosis factor	interleukin-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Enhanced release of interleukin-10 and soluble tumor_necrosis_factor receptors as novel principles of methylxanthine action in murine models of endotoxic_shock .
9086171	0	tumor_necrosis_factor	75,96	interleukin-10	43,57	tumor necrosis factor	interleukin-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Differential effects of pentoxifylline and interleukin-10 on production of tumor_necrosis_factor and inducible nitric_oxide synthase by murine macrophages .
3265420	0	tumor_necrosis_factor	25,46	interleukin-2	104,117	tumor necrosis factor	interleukin-2	7124	3558	Gene	Gene	circulating|dobj|START_ENTITY circulating|nmod|END_ENTITY	Induction of circulating tumor_necrosis_factor -LRB- TNF_alpha -RRB- as the mechanism for the febrile response to interleukin-2 -LRB- IL-2 -RRB- in cancer patients .
11007957	0	tumor_necrosis_factor	23,44	interleukin-6	94,107	tumor necrosis factor	interleukin-6	7124	3569	Gene	Gene	regulation|compound|START_ENTITY regulation|nmod|END_ENTITY	Signal transduction by tumor_necrosis_factor and gene regulation of the inflammatory cytokine interleukin-6 .
12923493	0	tumor_necrosis_factor	109,130	interleukin-6	185,198	tumor necrosis factor	interleukin-6	7124	3569	Gene	Gene	evokes|compound|START_ENTITY monocytes|nmod|evokes expression|nmod|monocytes Modulation|nmod|expression lipopolysaccharide|nsubj|Modulation lipopolysaccharide|advcl|enhances enhances|nsubj|END_ENTITY	Modulation of toll-like_receptor_4 expression on human monocytes by tumor_necrosis_factor and interleukin-6 : tumor_necrosis_factor evokes lipopolysaccharide hyporesponsiveness , whereas interleukin-6 enhances lipopolysaccharide activity .
12923493	0	tumor_necrosis_factor	68,89	interleukin-6	185,198	tumor necrosis factor	interleukin-6	7124	3569	Gene	Gene	evokes|compound|START_ENTITY monocytes|nmod|evokes expression|nmod|monocytes Modulation|nmod|expression lipopolysaccharide|nsubj|Modulation lipopolysaccharide|advcl|enhances enhances|nsubj|END_ENTITY	Modulation of toll-like_receptor_4 expression on human monocytes by tumor_necrosis_factor and interleukin-6 : tumor_necrosis_factor evokes lipopolysaccharide hyporesponsiveness , whereas interleukin-6 enhances lipopolysaccharide activity .
15906094	0	tumor_necrosis_factor	54,75	interleukin-6	21,34	tumor necrosis factor	interleukin-6	7124	3569	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Association tests of interleukin-6 -LRB- IL-6 -RRB- and type II tumor_necrosis_factor receptor -LRB- TNFR2 -RRB- genes with bone_mineral_density in Caucasians using a re-sampling approach .
7852449	1	tumor_necrosis_factor	43,64	interleukin-6	81,94	tumor necrosis factor	interleukin-6	100135630(Tax:10141)	106027696	Gene	Gene	interleukin-1|compound|START_ENTITY interleukin-1|nummod|END_ENTITY	The production of tumor_necrosis_factor , interleukin-1 , interleukin-6 , and prostaglandin_E2 by isolated enterocytes and gut macrophages : effect of lipopolysaccharide and thermal_injury .
8034659	0	tumor_necrosis_factor	52,73	interleukin-6	30,43	tumor necrosis factor	interleukin-6	7124	3569	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|gene gene|amod|END_ENTITY	Differential induction of the interleukin-6 gene by tumor_necrosis_factor and interleukin-1 .
9811328	0	tumor_necrosis_factor	199,220	interleukin-6	119,132	tumor necrosis factor	interleukin-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	superfamily|compound|START_ENTITY ligands|nmod|superfamily comparison|nmod|ligands mice|dep|comparison induces|nmod|mice induces|dobj|END_ENTITY	Intracerebroventricular injection of anti-Fas activates the hypothalamus-pituitary-adrenal_axis and induces peripheral interleukin-6 and serum_amyloid_A in mice : comparison with other ligands of the tumor_necrosis_factor / nerve growth factor receptor superfamily .
3494060	0	tumor_necrosis_factor	50,71	interleukin_1	33,46	tumor necrosis factor	interleukin 1	7124	3552	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of membrane-associated interleukin_1 by tumor_necrosis_factor in human fibroblasts .
2263237	0	tumor_necrosis_factor	151,172	interleukin_2	110,123	tumor necrosis factor	interleukin 2	21926(Tax:10090)	16183(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	-LSB- Induction of lymphokine activated killer -LRB- LAK -RRB- and prolongation of its activity by intrasplenic injection of interleukin_2 -LRB- IL-2 -RRB- in combination with tumor_necrosis_factor -LRB- TNF -RRB- -RSB- .
3121359	0	tumor_necrosis_factor	12,33	interleukin_2	45,58	tumor necrosis factor	interleukin 2	103694380	116562(Tax:10116)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|amod|END_ENTITY	Recombinant tumor_necrosis_factor can induce interleukin_2 receptor expression and cytolytic activity in a rat x mouse T cell hybrid .
17725274	0	tumor_necrosis_factor	86,107	interleukin_6	121,134	tumor necrosis factor	interleukin 6	7124	3569	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY vascular_endothelial_growth_factor|appos|END_ENTITY	-LSB- The assessment of the correlation between vascular_endothelial_growth_factor -LRB- VEGF -RRB- , tumor_necrosis_factor -LRB- TNF-alpha -RRB- , interleukin_6 -LRB- IL-6 -RRB- , glycaemic control -LRB- HbA1c -RRB- and the development of the diabetic_retinopathy in children with diabetes_mellitus_type_1 -RSB- .
1991487	0	tumor_necrosis_factor	82,103	interleukin_6	111,124	tumor necrosis factor	interleukin 6	7124	3569	Gene	Gene	START_ENTITY|dobj|stimulation stimulation|amod|END_ENTITY	L-arginine-dependent destruction of intrahepatic malaria parasites in response to tumor_necrosis_factor and/or interleukin_6 stimulation .
2364381	0	tumor_necrosis_factor	49,70	interleukin_6	91,104	tumor necrosis factor	interleukin 6	103694380	24498(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY mediators|nmod|effects Search|nmod|mediators Search|dep|role role|nmod|END_ENTITY	Search for mediators of the lipogenic effects of tumor_necrosis_factor : potential role for interleukin_6 .
2334896	0	tumor_necrosis_factor	38,59	interleukins_2_and_4	14,34	tumor necrosis factor	interleukins 2 and 4	21926(Tax:10090)	16183;16189	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Influences of interleukins_2_and_4 on tumor_necrosis_factor production by murine mononuclear phagocytes .
1618817	0	tumor_necrosis_factor	81,102	low_density_lipoprotein_receptor	13,45	tumor necrosis factor	low density lipoprotein receptor	7124	3949	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of low_density_lipoprotein_receptor and a transcription factor SP-1 by tumor_necrosis_factor in human microvascular endothelial cells .
1912581	0	tumor_necrosis_factor	118,139	macrophage_colony-stimulating_factor	73,109	tumor necrosis factor	macrophage colony-stimulating factor	7124	1435	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Involvement of a nuclear_factor-kappa_B-like protein in induction of the macrophage_colony-stimulating_factor gene by tumor_necrosis_factor .
10501470	0	tumor_necrosis_factor	111,132	p55	144,147	tumor necrosis factor	p55	103694380	25625(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|dep|END_ENTITY	Effects of circulating tumor_necrosis_factor on the neuronal activity and expression of the genes encoding the tumor_necrosis_factor receptors -LRB- p55 and p75 -RRB- in the rat brain : a view from the blood-brain barrier .
10501470	0	tumor_necrosis_factor	23,44	p55	144,147	tumor necrosis factor	p55	103694380	25625(Tax:10116)	Gene	Gene	circulating|dobj|START_ENTITY circulating|nmod|activity activity|nmod|genes genes|acl|encoding encoding|dobj|receptors receptors|dep|END_ENTITY	Effects of circulating tumor_necrosis_factor on the neuronal activity and expression of the genes encoding the tumor_necrosis_factor receptors -LRB- p55 and p75 -RRB- in the rat brain : a view from the blood-brain barrier .
11078604	0	tumor_necrosis_factor	32,53	p55	20,23	tumor necrosis factor	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Divergent roles for p55 and p75 tumor_necrosis_factor receptors in the pathogenesis of MOG -LRB- 35-55 -RRB- - induced experimental_autoimmune_encephalomyelitis .
21594476	0	tumor_necrosis_factor	38,59	p55	61,64	tumor necrosis factor	p55	7124	7132	Gene	Gene	receptors|nmod|START_ENTITY levels|nmod|receptors levels|dep|END_ENTITY	Serum levels of soluble receptors for tumor_necrosis_factor -LRB- p55 and p75 sTNFr -RRB- in patients with cervical_cancer .
24856420	0	tumor_necrosis_factor	10,31	p55	41,44	tumor necrosis factor	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Impact of tumor_necrosis_factor receptor p55 deficiency in susceptibility of C57BL/6 mice to infection with Leishmania -LRB- Leishmania -RRB- amazonensis .
7504889	0	tumor_necrosis_factor	72,93	p55	68,71	tumor necrosis factor	p55	7124	7132	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Tumor_necrosis_factor activates human endothelial cells through the p55 tumor_necrosis_factor receptor but the p75 receptor contributes to activation at low tumor_necrosis_factor concentration .
8920779	0	tumor_necrosis_factor	38,59	p55	61,64	tumor necrosis factor	p55	7124	7132	Gene	Gene	receptors|nmod|START_ENTITY levels|nmod|receptors levels|dep|END_ENTITY	Serum levels of soluble receptors for tumor_necrosis_factor -LRB- p55 and p75 sTNFr -RRB- in endometrial_cancer .
9348317	0	tumor_necrosis_factor	22,43	p55	66,69	tumor necrosis factor	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY mediated|nsubjpass|activity mediated|nmod|TNF_receptors TNF_receptors|amod|END_ENTITY	Antiviral activity of tumor_necrosis_factor -LRB- TNF -RRB- is mediated via p55 and p75 TNF_receptors .
11438547	0	tumor_necrosis_factor	24,45	p60	55,58	tumor necrosis factor	p60	21926(Tax:10090)	109679(Tax:10090)	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Genetic deletion of the tumor_necrosis_factor receptor p60 or p80 abrogates ligand-mediated activation of nuclear factor-kappa B and of mitogen-activated protein kinases in macrophages .
7780141	0	tumor_necrosis_factor	49,70	p60	28,31	tumor necrosis factor	p60	7124	7984	Gene	Gene	receptors|compound|START_ENTITY forms|nmod|receptors forms|amod|END_ENTITY	Retinoids downregulate both p60 and p80 forms of tumor_necrosis_factor receptors in human histiocytic lymphoma U-937 cells .
8051124	0	tumor_necrosis_factor	85,106	p60	81,84	tumor necrosis factor	p60	7124	8878	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Identification of a protein kinase associated with the cytoplasmic domain of the p60 tumor_necrosis_factor receptor .
12858186	0	tumor_necrosis_factor	102,123	p75	98,101	tumor necrosis factor	p75	21926(Tax:10090)	21938(Tax:10090)	Gene	Gene	protein|compound|START_ENTITY protein|amod|END_ENTITY	Electro-gene therapy of collagen-induced_arthritis by using an expression plasmid for the soluble p75 tumor_necrosis_factor receptor-Fc fusion protein .
7504889	0	tumor_necrosis_factor	157,178	p75	111,114	tumor necrosis factor	p75	7124	7133	Gene	Gene	concentration|compound|START_ENTITY activation|nmod|concentration contributes|xcomp|activation contributes|nsubj|receptor receptor|amod|END_ENTITY	Tumor_necrosis_factor activates human endothelial cells through the p55 tumor_necrosis_factor receptor but the p75 receptor contributes to activation at low tumor_necrosis_factor concentration .
7559483	0	tumor_necrosis_factor	39,60	p75	35,38	tumor necrosis factor	p75	7124	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Casein_kinase-1 phosphorylates the p75 tumor_necrosis_factor receptor and negatively regulates tumor_necrosis_factor signaling for apoptosis .
9219699	0	tumor_necrosis_factor	59,80	p75	91,94	tumor necrosis factor	p75	7124	7133	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Treatment of rheumatoid_arthritis with a recombinant human tumor_necrosis_factor receptor -LRB- p75 -RRB- - Fc fusion protein .
1730604	0	tumor_necrosis_factor	69,90	phospholipase_A2	118,134	tumor necrosis factor	phospholipase A2	7124	151056	Gene	Gene	START_ENTITY|acl|cause cause|dobj|activation activation|nmod|END_ENTITY	Inhibitors of transcription and translation act synergistically with tumor_necrosis_factor to cause the activation of phospholipase_A2 .
7684376	0	tumor_necrosis_factor	92,113	phospholipase_A2	37,53	tumor necrosis factor	phospholipase A2	7124	151056	Gene	Gene	action|nmod|START_ENTITY crucial|nmod|action crucial|nsubj|END_ENTITY	Arachidonic_acid-selective cytosolic phospholipase_A2 is crucial in the cytotoxic action of tumor_necrosis_factor .
1436316	0	tumor_necrosis_factor	87,108	plasminogen_activator_inhibitor	8,39	tumor necrosis factor	plasminogen activator inhibitor	103694380	24617(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of plasminogen_activator_inhibitor on nephrotoxic_nephritis and its modulation by tumor_necrosis_factor .
1846762	0	tumor_necrosis_factor	85,106	thrombomodulin	14,28	tumor necrosis factor	thrombomodulin	7124	7056	Gene	Gene	effects|nmod|START_ENTITY Expression|dep|effects Expression|nmod|END_ENTITY	Expression of thrombomodulin by smooth muscle cells in culture : different effects of tumor_necrosis_factor and cyclic_adenosine_monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture .
1846762	0	tumor_necrosis_factor	85,106	thrombomodulin	145,159	tumor necrosis factor	thrombomodulin	7124	7056	Gene	Gene	effects|nmod|START_ENTITY effects|nmod|expression expression|compound|END_ENTITY	Expression of thrombomodulin by smooth muscle cells in culture : different effects of tumor_necrosis_factor and cyclic_adenosine_monophosphate on thrombomodulin expression by endothelial cells and smooth muscle cells in culture .
12362984	0	tumor_necrosis_factor	52,73	tumor_necrosis_factor	82,103	tumor necrosis factor	tumor necrosis factor	101843732	101843732	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Molecular cloning and sequencing of partial cDNA of tumor_necrosis_factor and p75 tumor_necrosis_factor receptor of Syrian_golden_hamster -LRB- Mesocricetus_auratus -RRB- with the use of universal primers .
12362984	0	tumor_necrosis_factor	82,103	tumor_necrosis_factor	52,73	tumor necrosis factor	tumor necrosis factor	101843732	101843732	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Molecular cloning and sequencing of partial cDNA of tumor_necrosis_factor and p75 tumor_necrosis_factor receptor of Syrian_golden_hamster -LRB- Mesocricetus_auratus -RRB- with the use of universal primers .
2121330	0	tumor_necrosis_factor	49,70	tumor_necrosis_factor	90,111	tumor necrosis factor	tumor necrosis factor	7124	7124	Gene	Gene	expression|compound|START_ENTITY activation|nmod|expression activation|nmod|END_ENTITY	Phospholipase_A2 activation and autoinduction of tumor_necrosis_factor gene expression by tumor_necrosis_factor .
2121330	0	tumor_necrosis_factor	90,111	tumor_necrosis_factor	49,70	tumor necrosis factor	tumor necrosis factor	7124	7124	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|expression expression|compound|END_ENTITY	Phospholipase_A2 activation and autoinduction of tumor_necrosis_factor gene expression by tumor_necrosis_factor .
3932069	0	tumor_necrosis_factor	42,63	tumor_necrosis_factor	90,111	tumor necrosis factor	tumor necrosis factor	7124	21926(Tax:10090)	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and expression of human tumor_necrosis_factor and comparison with mouse tumor_necrosis_factor .
3932069	0	tumor_necrosis_factor	90,111	tumor_necrosis_factor	42,63	tumor necrosis factor	tumor necrosis factor	21926(Tax:10090)	7124	Gene	Gene	cloning|nmod|START_ENTITY cloning|nmod|END_ENTITY	Molecular cloning and expression of human tumor_necrosis_factor and comparison with mouse tumor_necrosis_factor .
7683925	0	tumor_necrosis_factor	28,49	urokinase-type_plasminogen_activator	80,116	tumor necrosis factor	urokinase-type plasminogen activator	7124	5328	Gene	Gene	induction|compound|START_ENTITY Role|nmod|induction Role|nmod|END_ENTITY	Role of protein_kinase_C in tumor_necrosis_factor induction of endothelial cell urokinase-type_plasminogen_activator .
22386367	0	tumor_necrosis_factor-a	33,56	CD44	14,18	tumor necrosis factor-a	CD44	7124	960	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|compound|END_ENTITY	Regulation of CD44 expression by tumor_necrosis_factor-a and its potential role in breast_cancer cell migration .
21570957	0	tumor_necrosis_factor-a	19,42	CYP3A11	106,113	tumor necrosis factor-a	CYP3A11	21926(Tax:10090)	13112(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Selective role for tumor_necrosis_factor-a , but not interleukin-1 or Kupffer cells , in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a noninvasive intestinal pathogen .
25399891	0	tumor_necrosis_factor-a	89,112	Ezrin	9,14	tumor necrosis factor-a	Ezrin	24835(Tax:10116)	54319(Tax:10116)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Role Role|nmod|END_ENTITY	-LSB- Role of Ezrin in the injury of rat pulmonary microvascular endothelial cells induced by tumor_necrosis_factor-a and the impact of Rac_1 -RSB- .
23664593	0	tumor_necrosis_factor-a	24,47	FGL2	8,12	tumor necrosis factor-a	FGL2	7124	10875	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|END_ENTITY	Soluble FGL2 induced by tumor_necrosis_factor-a and interferon-y in CD4 + T cells through MAPK pathway in human renal allograft acute rejection .
25026345	0	tumor_necrosis_factor-a	32,55	ICAM-1	121,127	tumor necrosis factor-a	ICAM-1	7124	3383	Gene	Gene	START_ENTITY|dep|expression expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
23647831	0	tumor_necrosis_factor-a	23,46	Interleukin-1b	0,14	tumor necrosis factor-a	Interleukin-1b	24835(Tax:10116)	24494(Tax:10116)	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Interleukin-1b induces tumor_necrosis_factor-a secretion from rat hepatocytes .
21428909	0	tumor_necrosis_factor-a	76,99	MMP-9	28,33	tumor necrosis factor-a	MMP-9	7124	4318	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Double-stranded RNA induces MMP-9 gene expression in HaCaT keratinocytes by tumor_necrosis_factor-a .
22508410	0	tumor_necrosis_factor-a	15,38	Nramp1	90,96	tumor necrosis factor-a	Nramp1	7124	6556	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	High levels of tumor_necrosis_factor-a downregulate antimicrobial iron transport protein , Nramp1 , in chronic hemodialysis patients : a key factor for infection risk .
23677169	0	tumor_necrosis_factor-a	44,67	Pituitary_tumor_transforming_gene_1	0,35	tumor necrosis factor-a	Pituitary tumor transforming gene 1	7124	9232	Gene	Gene	production|amod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Pituitary_tumor_transforming_gene_1 induces tumor_necrosis_factor-a production from keratinocytes : implication for involvement in the pathophysiology of psoriasis .
22948157	0	tumor_necrosis_factor-a	59,82	Prolyl_hydroxylase_3	0,20	tumor necrosis factor-a	Prolyl hydroxylase 3	7124	112399	Gene	Gene	effects|nmod|START_ENTITY modulates|dobj|effects modulates|nsubj|END_ENTITY	Prolyl_hydroxylase_3 -LRB- PHD3 -RRB- modulates catabolic effects of tumor_necrosis_factor-a -LRB- TNF-a -RRB- on cells of the nucleus pulposus through co-activation of nuclear factor kB -LRB- NF-kB -RRB- / p65 signaling .
20674553	0	tumor_necrosis_factor-a	46,69	TNF-a	71,76	tumor necrosis factor-a	TNF-a	7124	7124	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of cell growth and potentiation of tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced apoptosis by a phenanthroindolizidine_alkaloid antofine in human colon_cancer cells .
21731245	0	tumor_necrosis_factor-a	14,37	TNF-a	39,44	tumor necrosis factor-a	TNF-a	7124	7124	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Evaluation of tumor_necrosis_factor-a -LRB- TNF-a -RRB- levels in plasma and their correlation with periodontal status in obese and non-obese subjects .
24469604	0	tumor_necrosis_factor-a	40,63	TNF-a	65,70	tumor necrosis factor-a	TNF-a	7124	7124	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Comparative effectiveness of cycling of tumor_necrosis_factor-a -LRB- TNF-a -RRB- inhibitors versus switching to non-TNF biologics in rheumatoid_arthritis patients with inadequate response to TNF-a inhibitor using a Bayesian approach .
25859403	0	tumor_necrosis_factor-a	61,84	TNF-a	86,91	tumor necrosis factor-a	TNF-a	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Oral administration of melatonin modulates the expression of tumor_necrosis_factor-a -LRB- TNF-a -RRB- gene in irradiated rat cervical spinal cord .
8988238	0	tumor_necrosis_factor-a	7,30	TNF-a	32,37	tumor necrosis factor-a	TNF-a	7124	7124	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Plasma tumor_necrosis_factor-a -LRB- TNF-a -RRB- levels in Gaucher_disease .
25398810	0	tumor_necrosis_factor-a	21,44	TNFA	46,50	tumor necrosis factor-a	TNFA	7124	7124	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Relationship between tumor_necrosis_factor-a -LRB- TNFA -RRB- gene polymorphisms and cardiac_sarcoidosis .
22460559	0	tumor_necrosis_factor-a	68,91	TRAF4	106,111	tumor necrosis factor-a	TRAF4	7124	9618	Gene	Gene	signaling|amod|START_ENTITY signaling|nmod|END_ENTITY	Divergent effects of p47 -LRB- phox -RRB- phosphorylation at S303-4 or S379 on tumor_necrosis_factor-a signaling via TRAF4 and MAPK in endothelial cells .
21518085	0	tumor_necrosis_factor-a	124,147	Transforming_growth_factor-b1	0,29	tumor necrosis factor-a	Transforming growth factor-b1	24835(Tax:10116)	59086(Tax:10116)	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Transforming_growth_factor-b1 suppresses the up-regulation of matrix_metalloproteinase-2 by lung fibroblasts in response to tumor_necrosis_factor-a .
23770055	0	tumor_necrosis_factor-a	75,98	VCAM-1	107,113	tumor necrosis factor-a	VCAM-1	7124	7412	Gene	Gene	START_ENTITY|acl|induced induced|dobj|expression expression|amod|END_ENTITY	Sphingosine-1-phosphate_receptor-2 mediated NFkB activation contributes to tumor_necrosis_factor-a induced VCAM-1 and ICAM-1 expression in endothelial cells .
24566135	0	tumor_necrosis_factor-a	29,52	calreticulin	8,20	tumor necrosis factor-a	calreticulin	7124	811	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Soluble calreticulin induces tumor_necrosis_factor-a -LRB- TNF-a -RRB- and interleukin _ -LRB- IL -RRB- -6 production by macrophages through mitogen-activated protein kinase -LRB- MAPK -RRB- and NFkB signaling pathways .
22154272	0	tumor_necrosis_factor-a	114,137	chemerin	164,172	tumor necrosis factor-a	chemerin	7124	5919	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Increased levels of chemerin_and_its_receptor , _ chemokine-like_receptor-1 , in obesity are related to inflammation : tumor_necrosis_factor-a stimulates mRNA levels of chemerin in visceral adipocytes from obese patients .
22154272	0	tumor_necrosis_factor-a	114,137	chemerin	164,172	tumor necrosis factor-a	chemerin	7124	5919	Gene	Gene	levels|amod|START_ENTITY levels|nmod|END_ENTITY	Increased levels of chemerin_and_its_receptor , _ chemokine-like_receptor-1 , in obesity are related to inflammation : tumor_necrosis_factor-a stimulates mRNA levels of chemerin in visceral adipocytes from obese patients .
25504041	0	tumor_necrosis_factor-a	70,93	coagulation_factor_VII	18,40	tumor necrosis factor-a	coagulation factor VII	21926(Tax:10090)	14068(Tax:10090)	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|production production|nmod|END_ENTITY	The production of coagulation_factor_VII by adipocytes is enhanced by tumor_necrosis_factor-a or isoproterenol .
25026345	0	tumor_necrosis_factor-a	32,55	intercellular_adhesion_molecule-1	86,119	tumor necrosis factor-a	intercellular adhesion molecule-1	7124	3383	Gene	Gene	START_ENTITY|dep|expression expression|nmod|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
23602201	0	tumor_necrosis_factor-a	5,28	interleukin-10	29,43	tumor necrosis factor-a	interleukin-10	7124	3586	Gene	Gene	START_ENTITY|parataxis|associated associated|nsubjpass|ratio ratio|amod|END_ENTITY	High tumor_necrosis_factor-a / interleukin-10 ratio is associated with hepatocellular_carcinoma in patients with chronic_hepatitis_C .
25547245	0	tumor_necrosis_factor-a	111,134	interleukin-34	14,28	tumor necrosis factor-a	interleukin-34	7124	146433	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Expression of interleukin-34 and colony_stimulating_factor-1 in the stimulated periodontal ligament cells with tumor_necrosis_factor-a UNASSIGNED : Tumor_necrosis_factor-a -LRB- TNF-a -RRB- directly and indirectly plays a crucial role in osteoclastogenesis .
24891006	0	tumor_necrosis_factor-a	46,69	interleukin-6	13,26	tumor necrosis factor-a	interleukin-6	7124	3569	Gene	Gene	Elevation|nmod|START_ENTITY Elevation|nmod|END_ENTITY	Elevation of interleukin-6 and attenuation of tumor_necrosis_factor-a during wheelchair half marathon in athletes with cervical spinal_cord_injuries .
23878869	0	tumor_necrosis_factor-a	58,81	microRNA-146a	27,40	tumor necrosis factor-a	microRNA-146a	24835(Tax:10116)	100314241(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of transfection of microRNA-146a on expression of tumor_necrosis_factor-a in alveolar macrophages -RSB- .
25384061	0	tumor_necrosis_factor-a	43,66	myocardin	19,28	tumor necrosis factor-a	myocardin	7124	93649	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Dual regulation of myocardin expression by tumor_necrosis_factor-a in vascular smooth muscle cells .
25026345	0	tumor_necrosis_factor-a	32,55	p53	130,133	tumor necrosis factor-a	p53	7124	7157	Gene	Gene	START_ENTITY|dep|expression expression|appos|END_ENTITY	DaoTan decoction -LRB- DTD -RRB- inhibits tumor_necrosis_factor-a -LRB- TNF-a -RRB- - induced expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- , p53 and p21 , in human umbilical vein endothelia cells -LRB- HUVECs -RRB- .
22210320	0	tumor_necrosis_factor-a	18,41	sex_hormone-binding_globulin	60,88	tumor necrosis factor-a	sex hormone-binding globulin	7124	6462	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Potential role of tumor_necrosis_factor-a in downregulating sex_hormone-binding_globulin .
25377316	0	tumor_necrosis_factor-a	97,120	suppressor_of_cytokine_signaling_3	22,56	tumor necrosis factor-a	suppressor of cytokine signaling 3	7124	9021	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Intestinal epithelial suppressor_of_cytokine_signaling_3 enhances microbial-induced inflammatory tumor_necrosis_factor-a , contributing to epithelial barrier dysfunction .
24438626	0	tumor_necrosis_factor-a	61,84	surfactant_protein_A	10,30	tumor necrosis factor-a	surfactant protein A	7124	653509	Gene	Gene	expression|amod|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of surfactant_protein_A on lipopolysaccharide-induced tumor_necrosis_factor-a expression in human proximal tubular epithelial cells .
17940218	0	tumor_necrosis_factor-alpha	60,87	Adiponectin	0,11	tumor necrosis factor-alpha	Adiponectin	7124	9370	Gene	Gene	induced|nmod|START_ENTITY activation|acl|induced suppresses|dobj|activation suppresses|nsubj|END_ENTITY	Adiponectin suppresses IkappaB kinase activation induced by tumor_necrosis_factor-alpha or high glucose in endothelial cells : role of cAMP and AMP kinase signaling .
18174285	0	tumor_necrosis_factor-alpha	46,73	Adiponectin	0,11	tumor necrosis factor-alpha	Adiponectin	7124	9370	Gene	Gene	effect|nmod|START_ENTITY effect|dep|antagonizes antagonizes|compound|END_ENTITY	Adiponectin antagonizes stimulatory effect of tumor_necrosis_factor-alpha on vascular smooth muscle cell calcification : regulation of growth_arrest-specific_gene_6-mediated survival pathway by adenosine_5 ' - monophosphate-activated protein kinase .
18088351	0	tumor_necrosis_factor-alpha	49,76	Antithrombin	0,12	tumor necrosis factor-alpha	Antithrombin	7124	462	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Antithrombin inhibits lipopolysaccharide-induced tumor_necrosis_factor-alpha production by monocytes in vitro through inhibition of Egr-1 expression .
10428302	0	tumor_necrosis_factor-alpha	18,45	CCR2	58,62	tumor necrosis factor-alpha	CCR2	7124	729230	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Downregulation by tumor_necrosis_factor-alpha of monocyte CCR2 expression and monocyte_chemotactic_protein-1-induced transendothelial migration is antagonized by oxidized low-density lipoprotein : a potential mechanism of monocyte retention in atherosclerotic_lesions .
15145213	0	tumor_necrosis_factor-alpha	98,125	CD34	81,85	tumor necrosis factor-alpha	CD34	7124	947	Gene	Gene	cells|nmod|START_ENTITY cells|compound|END_ENTITY	Codevelopment of dendritic cells along with erythroid differentiation from human CD34 -LRB- + -RRB- cells by tumor_necrosis_factor-alpha .
8723796	0	tumor_necrosis_factor-alpha	135,162	CD34	74,78	tumor necrosis factor-alpha	CD34	7124	947	Gene	Gene	induction|nmod|START_ENTITY mediated|nmod|induction mediated|nsubj|effects effects|nmod|interleukin interleukin|nmod|transduction transduction|nmod|progenitors progenitors|compound|END_ENTITY	Inhibitory effects of interleukin 12 on retroviral gene transduction into CD34 cord blood myeloid progenitors mediated by induction of tumor_necrosis_factor-alpha .
9285527	0	tumor_necrosis_factor-alpha	134,161	CD36	44,48	tumor necrosis factor-alpha	CD36	7124	948	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|domain domain|nmod|END_ENTITY	The carboxyl-terminal cytoplasmic domain of CD36 is required for oxidized low-density lipoprotein modulation of NF-kappaB activity by tumor_necrosis_factor-alpha .
16291871	0	tumor_necrosis_factor-alpha	71,98	CD38	0,4	tumor necrosis factor-alpha	CD38	7124	952	Gene	Gene	treated|nmod|START_ENTITY cells|acl|treated steroid|nmod|cells insensitive|xcomp|steroid insensitive|nsubj|expression expression|compound|END_ENTITY	CD38 expression is insensitive to steroid action in cells treated with tumor_necrosis_factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform .
16571778	0	tumor_necrosis_factor-alpha	49,76	CD38	30,34	tumor necrosis factor-alpha	CD38	7124	952	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Transcriptional regulation of CD38 expression by tumor_necrosis_factor-alpha in human airway smooth muscle cells : role of NF-kappaB and sensitivity to glucocorticoids .
11796758	0	tumor_necrosis_factor-alpha	14,41	CD40	56,60	tumor necrosis factor-alpha	CD40	7124	958	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of tumor_necrosis_factor-alpha expression by CD40 ligation in BV-2 microglial cells .
15923644	0	tumor_necrosis_factor-alpha	148,175	CD44	207,211	tumor necrosis factor-alpha	CD44	7124	960	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Differential involvement of calmodulin-dependent protein kinase II-activated AP-1 and c-Jun_N-terminal_kinase-activated EGR-1 signaling pathways in tumor_necrosis_factor-alpha and lipopolysaccharide-induced CD44 expression in human monocytic cells .
7542295	0	tumor_necrosis_factor-alpha	36,63	CD44	17,21	tumor necrosis factor-alpha	CD44	7124	960	Gene	Gene	expression|nmod|START_ENTITY expression|nummod|END_ENTITY	Up-regulation of CD44 expression by tumor_necrosis_factor-alpha is neutralized by interleukin-10 in Langerhans cells .
8766549	0	tumor_necrosis_factor-alpha	77,104	CD45	64,68	tumor necrosis factor-alpha	CD45	7124	5788	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Epitope-specific engagement of the protein tyrosine phosphatase CD45 induces tumor_necrosis_factor-alpha gene expression via transcriptional mechanisms .
10782809	0	tumor_necrosis_factor-alpha	68,95	CD68	124,128	tumor necrosis factor-alpha	CD68	7124	968	Gene	Gene	START_ENTITY|acl|produced produced|nmod|cells cells|compound|END_ENTITY	Synovial_hyperplasia in HTLV-I associated arthropathy is induced by tumor_necrosis_factor-alpha produced by HTLV-I infected CD68 + cells .
15504546	0	tumor_necrosis_factor-alpha	24,51	CDK6	75,79	tumor necrosis factor-alpha	CDK6	7124	1021	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	In human immature BFU-E tumor_necrosis_factor-alpha not only downregulates CDK6 but also directly produces apoptosis which is prevented by stem_cell_factor .
10785514	0	tumor_necrosis_factor-alpha	33,60	Cyclooxygenase-2	0,16	tumor necrosis factor-alpha	Cyclooxygenase-2	7124	5743	Gene	Gene	proliferation|amod|START_ENTITY required|nmod|proliferation required|nsubjpass|END_ENTITY	Cyclooxygenase-2 is required for tumor_necrosis_factor-alpha - and angiotensin_II-mediated proliferation of vascular smooth muscle cells .
19218340	0	tumor_necrosis_factor-alpha	113,140	Cyclooxygenase-2	0,16	tumor necrosis factor-alpha	Cyclooxygenase-2	7124	5743	Gene	Gene	induced|nmod|START_ENTITY cholangiocarcinoma|acl|induced involved|nmod|cholangiocarcinoma involved|nsubjpass|END_ENTITY	Cyclooxygenase-2 is involved in the up-regulation of matrix_metalloproteinase-9 in cholangiocarcinoma induced by tumor_necrosis_factor-alpha .
14669262	0	tumor_necrosis_factor-alpha	122,149	E-selectin	44,54	tumor necrosis factor-alpha	E-selectin	7124	6401	Gene	Gene	stimulated|nmod|START_ENTITY stimulated|nsubj|effects effects|nmod|flavonoids flavonoids|nmod|expression expression|amod|END_ENTITY	Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor_necrosis_factor-alpha .
17170373	0	tumor_necrosis_factor-alpha	87,114	E-selectin	73,83	tumor necrosis factor-alpha	E-selectin	100009088(Tax:9986)	6401	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|induction induction|nmod|END_ENTITY	Vascular_endothelial_growth_factor synergistically enhances induction of E-selectin by tumor_necrosis_factor-alpha .
9848873	0	tumor_necrosis_factor-alpha	14,41	E-selectin	81,91	tumor necrosis factor-alpha	E-selectin	7124	6401	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibition of tumor_necrosis_factor-alpha - and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents .
12506117	0	tumor_necrosis_factor-alpha	73,100	Endothelial_nitric-oxide_synthase	0,33	tumor necrosis factor-alpha	Endothelial nitric-oxide synthase	21926(Tax:10090)	18127(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Endothelial_nitric-oxide_synthase enhances lipopolysaccharide-stimulated tumor_necrosis_factor-alpha expression via cAMP-mediated p38_MAPK pathway in cardiomyocytes .
14597634	0	tumor_necrosis_factor-alpha	123,150	Erk	89,92	tumor necrosis factor-alpha	Erk	7124	5594	Gene	Gene	stimulated|nmod|START_ENTITY cells|acl|stimulated END_ENTITY|nmod|cells	Cytosolic peroxiredoxin attenuates the activation of Jnk and p38 but potentiates that of Erk in Hela cells stimulated with tumor_necrosis_factor-alpha .
19061883	0	tumor_necrosis_factor-alpha	81,108	Erythropoietin	0,14	tumor necrosis factor-alpha	Erythropoietin	7124	2056	Gene	Gene	expression|amod|START_ENTITY inhibiting|dobj|expression induced|advcl|inhibiting ischemia-reperfusion|acl|induced attenuates|dobj|ischemia-reperfusion attenuates|nsubj|END_ENTITY	Erythropoietin attenuates ischemia-reperfusion induced lung_injury by inhibiting tumor_necrosis_factor-alpha and matrix_metalloproteinase-9 expression .
19631208	0	tumor_necrosis_factor-alpha	88,115	Erythropoietin	0,14	tumor necrosis factor-alpha	Erythropoietin	7124	2056	Gene	Gene	cytotoxicity|nmod|START_ENTITY protects|nmod|cytotoxicity protects|nsubj|END_ENTITY	Erythropoietin protects myocardin-expressing cardiac stem cells against cytotoxicity of tumor_necrosis_factor-alpha .
2338132	0	tumor_necrosis_factor-alpha	75,102	Erythropoietin	0,14	tumor necrosis factor-alpha	Erythropoietin	21926(Tax:10090)	13856(Tax:10090)	Gene	Gene	exposed|nmod|START_ENTITY mice|acl|exposed reverse|nmod|mice fails|xcomp|reverse fails|nsubj|END_ENTITY	Erythropoietin fails to reverse the anemia in mice continuously exposed to tumor_necrosis_factor-alpha in vivo .
11242125	0	tumor_necrosis_factor-alpha	102,129	Fas_associated_death_domain_protein	31,66	tumor necrosis factor-alpha	Fas associated death domain protein	21926(Tax:10090)	14082(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|expression expression|nmod|END_ENTITY	mRNA and protein expression of Fas_associated_death_domain_protein in apoptosic hepatocyte induced by tumor_necrosis_factor-alpha .
11734667	0	tumor_necrosis_factor-alpha	48,75	Fibrinogen	0,10	tumor necrosis factor-alpha	Fibrinogen	7124	2244	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Fibrinogen increases lipopolysaccharide-induced tumor_necrosis_factor-alpha and interleukin-8 release , and enhances tissue factor activity in monocytes in a modified whole blood system .
11502212	0	tumor_necrosis_factor-alpha	103,130	Focal_adhesion_kinase	0,21	tumor necrosis factor-alpha	Focal adhesion kinase	7124	5747	Gene	Gene	apoptosis|amod|START_ENTITY SMMC-7721|nmod|apoptosis sensitivity|nmod|SMMC-7721 affects|dobj|sensitivity affects|nsubj|END_ENTITY	Focal_adhesion_kinase affects the sensitivity of human hepatocellular_carcinoma cell line SMMC-7721 to tumor_necrosis_factor-alpha / cycloheximide-induced apoptosis by regulating protein_kinase_B levels .
7867077	0	tumor_necrosis_factor-alpha	101,128	Granulocyte-macrophage_colony-stimulating_factor	0,48	tumor necrosis factor-alpha	Granulocyte-macrophage colony-stimulating factor	7124	1437	Gene	Gene	region|amod|START_ENTITY regulate|dobj|region regulate|nsubj|END_ENTITY	Granulocyte-macrophage_colony-stimulating_factor and interleukin-4 differentially regulate the human tumor_necrosis_factor-alpha promoter region .
7545022	0	tumor_necrosis_factor-alpha	117,144	Granulocyte_colony-stimulating_factor	0,37	tumor necrosis factor-alpha	Granulocyte colony-stimulating factor	7124	1440	Gene	Gene	production|amod|START_ENTITY inhibition|nmod|production downregulates|nmod|inhibition downregulates|nsubj|END_ENTITY	Granulocyte_colony-stimulating_factor downregulates allogeneic immune responses by posttranscriptional inhibition of tumor_necrosis_factor-alpha production .
14975942	0	tumor_necrosis_factor-alpha	18,45	HLA-DP	88,94	tumor necrosis factor-alpha	HLA-DP	7124	3115	Gene	Gene	production|amod|START_ENTITY mediated|nsubjpass|production mediated|nmod|END_ENTITY	Beryllium-induced tumor_necrosis_factor-alpha production by CD4 + T cells is mediated by HLA-DP .
1421280	0	tumor_necrosis_factor-alpha	54,81	HNP-1	27,32	tumor necrosis factor-alpha	HNP-1	7124	574045	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	-LSB- Effects of human defensin HNP-1 on the production of tumor_necrosis_factor-alpha by human blood monocytes in vitro -RSB- .
10769087	0	tumor_necrosis_factor-alpha	24,51	ICAM-1	87,93	tumor necrosis factor-alpha	ICAM-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	release|amod|START_ENTITY correlation|nmod|release correlation|appos|upregulation upregulation|nmod|END_ENTITY	Temporal correlation of tumor_necrosis_factor-alpha release , upregulation of pulmonary ICAM-1 and VCAM-1 , neutrophil sequestration , and lung_injury in diet-induced pancreatitis .
12738545	0	tumor_necrosis_factor-alpha	73,100	ICAM-1	25,31	tumor necrosis factor-alpha	ICAM-1	7124	3383	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|Expression Expression|nmod|END_ENTITY	Expression of functional ICAM-1 on cultured human keratocytes induced by tumor_necrosis_factor-alpha .
17607964	0	tumor_necrosis_factor-alpha	229,256	ICAM-1	77,83	tumor necrosis factor-alpha	ICAM-1	7124	3383	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|csubj|-LSB- -LSB-|nmod|intercellular_adhesion_molecule-1 intercellular_adhesion_molecule-1|appos|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
1980110	0	tumor_necrosis_factor-alpha	115,142	ICAM-1	82,88	tumor necrosis factor-alpha	ICAM-1	7124	3383	Gene	Gene	release|nmod|START_ENTITY modulates|dobj|release modulates|nsubj|antibody antibody|appos|END_ENTITY	A monoclonal antibody directed against the human intercellular_adhesion_molecule -LRB- ICAM-1 -RRB- modulates the release of tumor_necrosis_factor-alpha , interferon-gamma and interleukin_1 .
7930472	0	tumor_necrosis_factor-alpha	104,131	ICAM-1	93,99	tumor necrosis factor-alpha	ICAM-1	24835(Tax:10116)	25464(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY rat|nmod|stimulation rat|dobj|cells cells|appos|END_ENTITY	Cultured rat hepatic sinusoidal endothelial cells express intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by tumor_necrosis_factor-alpha or interleukin-1_alpha stimulation .
10933609	0	tumor_necrosis_factor-alpha	72,99	IFN-gamma	0,9	tumor necrosis factor-alpha	IFN-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY PGE2|nmod|production effects|nmod|PGE2 inhibits|dobj|effects inhibits|nsubj|END_ENTITY	IFN-gamma inhibits the suppressive effects of PGE2 on the production of tumor_necrosis_factor-alpha by mouse macrophages .
15806975	0	tumor_necrosis_factor-alpha	80,107	IFN-gamma	68,77	tumor necrosis factor-alpha	IFN-gamma	7124	3458	Gene	Gene	interferon-gamma|appos|START_ENTITY interferon-gamma|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
15812247	0	tumor_necrosis_factor-alpha	97,124	IFN-gamma	40,49	tumor necrosis factor-alpha	IFN-gamma	7124	3458	Gene	Gene	NF-kappaB|nmod|START_ENTITY activation|nmod|NF-kappaB influences|nmod|activation influences|nmod|END_ENTITY	Cholera toxin potentiates influences of IFN-gamma through activation of NF-kappaB and release of tumor_necrosis_factor-alpha .
2201834	0	tumor_necrosis_factor-alpha	141,168	IL-1	114,118	tumor necrosis factor-alpha	IL-1	7124	3552	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Hemopoietin-1 activity of interleukin-1 -LRB- IL-1 -RRB- on acute_myeloid_leukemia colony-forming cells -LRB- AML-CFU -RRB- in vitro : IL-1 induces production of tumor_necrosis_factor-alpha which synergizes with IL-3 or granulocyte-macrophage_colony-stimulating_factor .
2201834	0	tumor_necrosis_factor-alpha	141,168	IL-1	41,45	tumor necrosis factor-alpha	IL-1	7124	3552	Gene	Gene	production|nmod|START_ENTITY activity|dep|production activity|nmod|END_ENTITY	Hemopoietin-1 activity of interleukin-1 -LRB- IL-1 -RRB- on acute_myeloid_leukemia colony-forming cells -LRB- AML-CFU -RRB- in vitro : IL-1 induces production of tumor_necrosis_factor-alpha which synergizes with IL-3 or granulocyte-macrophage_colony-stimulating_factor .
8175024	0	tumor_necrosis_factor-alpha	42,69	IL-1	152,156	tumor necrosis factor-alpha	IL-1	7124	3552	Gene	Gene	cells|nmod|START_ENTITY Transfection|nmod|cells antisense|nsubj|Transfection antisense|ccomp|abolishes abolishes|dobj|response response|nmod|_ _|appos|END_ENTITY	Transfection of ovarian_cancer cells with tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- antisense mRNA abolishes the proliferative response to interleukin-1 _ -LRB- IL-1 -RRB- but not TNF-alpha .
8889469	0	tumor_necrosis_factor-alpha	87,114	IL-1	27,31	tumor necrosis factor-alpha	IL-1	7124	3553	Gene	Gene	keratinocytes|nmod|START_ENTITY keratinocytes|nsubj|regulation regulation|nmod|END_ENTITY	Differential regulation of IL-1 and IL-1_receptor_antagonist in HaCaT keratinocytes by tumor_necrosis_factor-alpha and transforming_growth_factor-beta_1 .
8683105	0	tumor_necrosis_factor-alpha	84,111	IL-10	0,5	tumor necrosis factor-alpha	IL-10	7124	3586	Gene	Gene	enhanced|nmod|START_ENTITY enhanced|nsubjpass|production production|compound|END_ENTITY	IL-10 production is enhanced in human T cells by IL-12 and IL-6 and in monocytes by tumor_necrosis_factor-alpha .
8496597	0	tumor_necrosis_factor-alpha	80,107	IL-1_beta	109,118	tumor necrosis factor-alpha	IL-1 beta	7124	3553	Gene	Gene	IL-8|compound|START_ENTITY IL-8|dep|END_ENTITY	Differential action of cycloheximide and activation stimuli on transcription of tumor_necrosis_factor-alpha , IL-1_beta , IL-8 , and P53 genes in human monocytes .
9435641	0	tumor_necrosis_factor-alpha	70,97	IL-1_beta	39,48	tumor necrosis factor-alpha	IL-1 beta	7124	3553	Gene	Gene	roles|nmod|START_ENTITY production|dep|roles production|compound|END_ENTITY	Epinephrine inhibits endotoxin-induced IL-1_beta production : roles of tumor_necrosis_factor-alpha and IL-10 .
15806975	0	tumor_necrosis_factor-alpha	80,107	IL-2	135,139	tumor necrosis factor-alpha	IL-2	7124	3558	Gene	Gene	interferon-gamma|appos|START_ENTITY efficacy|appos|interferon-gamma interleukin-2|nsubj|efficacy interleukin-2|dobj|levels levels|appos|END_ENTITY	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
7482719	0	tumor_necrosis_factor-alpha	31,58	IL-2	60,64	tumor necrosis factor-alpha	IL-2	7124	3558	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	The relation of interleukin-6 , tumor_necrosis_factor-alpha , IL-2 , and IL-2_receptor levels to cellular rejection , allograft_dysfunction , and clinical events early after cardiac transplantation .
18176176	0	tumor_necrosis_factor-alpha	22,49	IL-6	15,19	tumor necrosis factor-alpha	IL-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY Interleukin-6|appos|levels Interleukin-6|appos|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
9773833	0	tumor_necrosis_factor-alpha	76,103	IL-6	129,133	tumor necrosis factor-alpha	IL-6	7124	3569	Gene	Gene	_|amod|START_ENTITY expression|nmod|_ expression|dep|beta beta|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
9773833	0	tumor_necrosis_factor-alpha	76,103	IL-8	135,139	tumor necrosis factor-alpha	IL-8	7124	3576	Gene	Gene	_|amod|START_ENTITY expression|nmod|_ expression|dep|beta beta|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
11755467	0	tumor_necrosis_factor-alpha	56,83	Interferon-alpha_2b	0,19	tumor necrosis factor-alpha	Interferon-alpha 2b	7124	3440	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Interferon-alpha_2b and vesnarinone influence levels of tumor_necrosis_factor-alpha , apoptosis , or interleukin_6 in ESKOL , a hairy cell leukemic cell line .
12960156	0	tumor_necrosis_factor-alpha	93,120	Interferon-gamma	0,16	tumor necrosis factor-alpha	Interferon-gamma	7124	3458	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|differentially differentially|amod|END_ENTITY	Interferon-gamma differentially regulates monocyte matrix metalloproteinase-1 and -9 through tumor_necrosis_factor-alpha and caspase_8 .
1516623	1	tumor_necrosis_factor-alpha	107,134	Interferon-gamma	54,70	tumor necrosis factor-alpha	Interferon-gamma	7124	3458	Gene	Gene	cytokine|appos|START_ENTITY combination|nmod|cytokine END_ENTITY|nmod|combination	I. Interferon-gamma in combination with a cytokine -LRB- not tumor_necrosis_factor-alpha -RRB- is required , but can not act alone in the inhibition of intracellular forms of L. aethiopica in THP1 cells .
16525716	0	tumor_necrosis_factor-alpha	46,73	Interferon-gamma	0,16	tumor necrosis factor-alpha	Interferon-gamma	24835(Tax:10116)	25712(Tax:10116)	Gene	Gene	enzyme/a|amod|START_ENTITY expression|nmod|enzyme/a expression|amod|END_ENTITY	Interferon-gamma down-regulates expression of tumor_necrosis_factor-alpha converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats .
17051336	0	tumor_necrosis_factor-alpha	72,99	Interferon-gamma	0,16	tumor necrosis factor-alpha	Interferon-gamma	7124	3458	Gene	Gene	activation|amod|START_ENTITY line|nmod|activation sensitizes|dobj|line sensitizes|nsubj|END_ENTITY	Interferon-gamma sensitizes the human salivary gland cell line , HSG , to tumor_necrosis_factor-alpha induced activation of dual apoptotic pathways .
7693830	0	tumor_necrosis_factor-alpha	65,92	Interferon-gamma	0,16	tumor necrosis factor-alpha	Interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	synergizes|nmod|START_ENTITY synergizes|nsubj|END_ENTITY	Interferon-gamma , but not interferon-alpha_beta , synergizes with tumor_necrosis_factor-alpha and lipid_A in the induction of nitric_oxide production by murine L929 cells .
18787467	0	tumor_necrosis_factor-alpha	133,160	Interleukin-10	0,14	tumor necrosis factor-alpha	Interleukin-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY interleukin-10|nmod|ratio fatty_liver_disease|amod|interleukin-10 biomarker|nmod|fatty_liver_disease biomarker|nsubj|END_ENTITY	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
18787467	0	tumor_necrosis_factor-alpha	18,45	Interleukin-10	0,14	tumor necrosis factor-alpha	Interleukin-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|nmod|ratio	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
1774433	0	tumor_necrosis_factor-alpha	47,74	Interleukin-1_alpha	0,19	tumor necrosis factor-alpha	Interleukin-1 alpha	21926(Tax:10090)	16175(Tax:10090)	Gene	Gene	hepatotoxicity|nmod|START_ENTITY enhances|dobj|hepatotoxicity enhances|nsubj|END_ENTITY	Interleukin-1_alpha enhances hepatotoxicity of tumor_necrosis_factor-alpha in galactosamine-sensitized mice .
12845752	0	tumor_necrosis_factor-alpha	20,47	Interleukin-1_beta	0,18	tumor necrosis factor-alpha	Interleukin-1 beta	280943(Tax:9913)	281251(Tax:9913)	Gene	Gene	induce|nsubj|START_ENTITY induce|advmod|END_ENTITY	Interleukin-1_beta , tumor_necrosis_factor-alpha and lipopolysaccharide induce expression of monocyte_chemoattractant_protein-1 in calf aortic smooth muscle cells .
1732280	0	tumor_necrosis_factor-alpha	32,59	Interleukin-1_beta	0,18	tumor necrosis factor-alpha	Interleukin-1 beta	7124	3553	Gene	Gene	expression|amod|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Interleukin-1_beta induction of tumor_necrosis_factor-alpha gene expression in human astroglioma cells .
8796819	0	tumor_necrosis_factor-alpha	51,78	Interleukin-1_beta	0,18	tumor necrosis factor-alpha	Interleukin-1 beta	715467(Tax:9544)	704701(Tax:9544)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|infusion infusion|amod|END_ENTITY	Interleukin-1_beta intra-amniotic infusion induces tumor_necrosis_factor-alpha , prostaglandin production , and preterm contractions in pregnant rhesus_monkeys .
1571090	0	tumor_necrosis_factor-alpha	39,66	Interleukin-4	0,13	tumor necrosis factor-alpha	Interleukin-4	7124	3565	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Interleukin-4 differentially regulates tumor_necrosis_factor-alpha gene expression by human T lymphocytes and monocytes .
15816837	0	tumor_necrosis_factor-alpha	119,146	Interleukin-4	0,13	tumor necrosis factor-alpha	Interleukin-4	7124	3565	Gene	Gene	induced|nmod|START_ENTITY synthesis|acl|induced enhancement|nmod|synthesis suppresses|dobj|enhancement suppresses|nsubj|END_ENTITY	Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor_necrosis_factor-alpha and interferon-gamma in human epidermis .
1601643	0	tumor_necrosis_factor-alpha	69,96	Interleukin-6	0,13	tumor necrosis factor-alpha	Interleukin-6	7124	3569	Gene	Gene	production|nmod|START_ENTITY prime|nmod|production prime|nsubj|END_ENTITY	Interleukin-6 can prime THP-1 macrophages for enhanced production of tumor_necrosis_factor-alpha in response to LPS .
18176176	0	tumor_necrosis_factor-alpha	22,49	Interleukin-6	0,13	tumor necrosis factor-alpha	Interleukin-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY END_ENTITY|appos|levels	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
8386026	0	tumor_necrosis_factor-alpha	100,127	Interleukin-6	0,13	tumor necrosis factor-alpha	Interleukin-6	7124	3569	Gene	Gene	beta|amod|START_ENTITY induced|nmod|beta proliferation|acl:relcl|induced inhibits|dobj|proliferation inhibits|nsubj|END_ENTITY	Interleukin-6 inhibits the proliferation of B-chronic_lymphocytic_leukemia cells that is induced by tumor_necrosis_factor-alpha or - beta .
21271591	0	tumor_necrosis_factor-alpha	40,67	Interleukin-8	0,13	tumor necrosis factor-alpha	Interleukin-8	7124	3576	Gene	Gene	production|acl|START_ENTITY production|amod|END_ENTITY	Interleukin-8 production in response to tumor_necrosis_factor-alpha by cholesteatoma keratinocytes in cell culture .
8228354	0	tumor_necrosis_factor-alpha	78,105	Interleukin-8	0,13	tumor necrosis factor-alpha	Interleukin-8	7124	3576	Gene	Gene	response|nmod|START_ENTITY cells|nmod|response production|nmod|cells production|amod|END_ENTITY	Interleukin-8 production by human peritoneal mesothelial cells in response to tumor_necrosis_factor-alpha , interleukin-1 , and medium conditioned by macrophages cocultured with Staphylococcus_epidermidis .
15196924	0	tumor_necrosis_factor-alpha	23,50	Ipaf	0,4	tumor necrosis factor-alpha	Ipaf	7124	58484	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Ipaf is upregulated by tumor_necrosis_factor-alpha in human leukemia cells .
8793801	0	tumor_necrosis_factor-alpha	8,35	MCP-1	54,59	tumor necrosis factor-alpha	MCP-1	7124	6347	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	Role of tumor_necrosis_factor-alpha on mesangial cell MCP-1 expression and monocyte migration : mechanisms mediated by signal transduction .
11908571	0	tumor_necrosis_factor-alpha	32,59	MMP-1	91,96	tumor necrosis factor-alpha	MMP-1	7124	4312	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	Synthesis of interleukin_1beta , tumor_necrosis_factor-alpha , and interstitial collagenase -LRB- MMP-1 -RRB- is eicosanoid dependent in human osteoarthritis synovial membrane explants : interactions with antiinflammatory cytokines .
11297541	0	tumor_necrosis_factor-alpha	38,65	MMP-9	116,121	tumor necrosis factor-alpha	MMP-9	7124	4318	Gene	Gene	Transforming_growth_factor-beta|dep|START_ENTITY mediated|nsubj|Transforming_growth_factor-beta mediated|dobj|activation activation|nmod|END_ENTITY	Transforming_growth_factor-beta - and tumor_necrosis_factor-alpha - mediated induction and proteolytic activation of MMP-9 in human skin .
9917505	0	tumor_necrosis_factor-alpha	101,128	MMP-9	30,35	tumor necrosis factor-alpha	MMP-9	7124	4318	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Transcriptional regulation of MMP-9 expression in stromal cells of human giant_cell_tumor_of_bone by tumor_necrosis_factor-alpha .
10880020	0	tumor_necrosis_factor-alpha	21,48	Mdr1	0,4	tumor necrosis factor-alpha	Mdr1	7124	5243	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Mdr1 promoter-driven tumor_necrosis_factor-alpha expression for a chemotherapy-controllable combined in vivo gene therapy and chemotherapy of tumors .
2222450	0	tumor_necrosis_factor-alpha	53,80	Mn-superoxide_dismutase	15,38	tumor necrosis factor-alpha	Mn-superoxide dismutase	7124	6648	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Stimulation of Mn-superoxide_dismutase expression by tumor_necrosis_factor-alpha : quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA .
10748079	0	tumor_necrosis_factor-alpha	25,52	NF-kappa_B	143,153	tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	expression|amod|START_ENTITY suppress|dobj|expression suppress|advcl|suppressing suppressing|nmod|END_ENTITY	Glucocorticoids suppress tumor_necrosis_factor-alpha expression by human monocytic THP-1 cells by suppressing transactivation through adjacent NF-kappa_B and c-Jun-activating transcription factor-2 binding sites in the promoter .
11390371	0	tumor_necrosis_factor-alpha	79,106	NF-kappa_B	138,148	tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	activation|amod|START_ENTITY activation|amod|END_ENTITY	Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor_necrosis_factor-alpha - and interleukin-1beta-induced NF-kappa_B activation .
11402028	0	tumor_necrosis_factor-alpha	92,119	NF-kappa_B	156,166	tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	secretion|amod|START_ENTITY coordinates|dobj|secretion coordinates|nmod|regulation regulation|nmod|END_ENTITY	Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor_necrosis_factor-alpha secretion through IKK regulation of NF-kappa_B .
11445585	0	tumor_necrosis_factor-alpha	157,184	NF-kappa_B	120,130	tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	regulating|nmod|START_ENTITY regulating|dobj|activation activation|amod|END_ENTITY	Atypical lambda/iota PKC conveys 5-lipoxygenase/leukotriene B4-mediated cross-talk between phospholipase_A2s regulating NF-kappa_B activation in response to tumor_necrosis_factor-alpha and interleukin-1beta .
11729200	0	tumor_necrosis_factor-alpha	53,80	NF-kappa_B	90,100	tumor necrosis factor-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	mechanism|nmod|START_ENTITY oxidase|nmod|mechanism induced|dep|oxidase induced|dobj|activation activation|amod|END_ENTITY	Role of neutrophil NADPH oxidase in the mechanism of tumor_necrosis_factor-alpha - induced NF-kappa_B activation and intercellular_adhesion_molecule-1 expression in endothelial cells .
12093792	0	tumor_necrosis_factor-alpha	81,108	NF-kappa_B	47,57	tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	cytokines|amod|START_ENTITY modulates|nmod|cytokines modulates|dobj|induction induction|amod|END_ENTITY	A novel PAAD-containing protein that modulates NF-kappa_B induction by cytokines tumor_necrosis_factor-alpha and interleukin-1beta .
16464740	0	tumor_necrosis_factor-alpha	24,51	NF-kappa_B	65,75	tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	START_ENTITY|nmod|I_kappa_B_alpha I_kappa_B_alpha|compound|END_ENTITY	Differential effects of tumor_necrosis_factor-alpha and CD40L on NF-kappa_B inhibitory proteins I_kappa_B_alpha , beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt_lymphoma cells .
7797515	0	tumor_necrosis_factor-alpha	55,82	NF-kappa_B	9,19	tumor necrosis factor-alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role for NF-kappa_B in the regulation of ferritin_H by tumor_necrosis_factor-alpha .
9990294	0	tumor_necrosis_factor-alpha	39,66	NF-kappa_B	94,104	tumor necrosis factor-alpha	NF-kappa B	7124	4790	Gene	Gene	synthesis|nmod|START_ENTITY Stimulation|nmod|synthesis mediated|nsubjpass|Stimulation mediated|nmod|complex complex|amod|END_ENTITY	Stimulation of hyaluronan synthesis by tumor_necrosis_factor-alpha is mediated by the p50/p65 NF-kappa_B complex in MRC-5 myofibroblasts .
10199558	0	tumor_necrosis_factor-alpha	78,105	NFkappaB	8,16	tumor necrosis factor-alpha	NFkappaB	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	factor|nmod|START_ENTITY stimulating|dobj|factor stimulating|nsubj|Role Role|nmod|END_ENTITY	Role of NFkappaB in the regulation of macrophage colony stimulating factor by tumor_necrosis_factor-alpha in ST2 bone stromal cells .
17706953	0	tumor_necrosis_factor-alpha	75,102	Osteoprotegerin	0,15	tumor necrosis factor-alpha	Osteoprotegerin	7124	4982	Gene	Gene	upregulates|nmod|START_ENTITY upregulates|nsubj|END_ENTITY	Osteoprotegerin upregulates endothelial cell adhesion molecule response to tumor_necrosis_factor-alpha associated with induction of angiopoietin-2 .
15124210	0	tumor_necrosis_factor-alpha	10,37	P-glycoprotein	73,87	tumor necrosis factor-alpha	P-glycoprotein	7124	5243	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of tumor_necrosis_factor-alpha and interferon-gamma on intestinal P-glycoprotein expression , activity , and localization in Caco-2 cells .
10221563	0	tumor_necrosis_factor-alpha	25,52	PC3	56,59	tumor necrosis factor-alpha	PC3	7124	57332	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	Cytotoxic sensitivity to tumor_necrosis_factor-alpha in PC3 and LNCaP prostatic_cancer cells is regulated by extracellular levels of SGP-2 -LRB- clusterin -RRB- .
8554585	0	tumor_necrosis_factor-alpha	33,60	Phospholipase_A2	0,16	tumor necrosis factor-alpha	Phospholipase A2	7124	151056	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Phospholipase_A2 is activated by tumor_necrosis_factor-alpha in primary hepatocytes stimulated by a deleted form of hepatocyte growth factor .
12788307	0	tumor_necrosis_factor-alpha	98,125	Prolactin	0,9	tumor necrosis factor-alpha	Prolactin	7124	5617	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Prolactin enhances production of interferon-gamma , interleukin-12 , and interleukin-10 , but not of tumor_necrosis_factor-alpha , in a stimulus-specific manner .
20686703	0	tumor_necrosis_factor-alpha	94,121	RelB	37,41	tumor necrosis factor-alpha	RelB	21926(Tax:10090)	5971	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Nuclear_factor-kappa_B family member RelB inhibits human_immunodeficiency_virus-1 Tat-induced tumor_necrosis_factor-alpha production .
9006895	0	tumor_necrosis_factor-alpha	111,138	SAPK	153,157	tumor necrosis factor-alpha	SAPK	7124	5601	Gene	Gene	activation|amod|START_ENTITY activation|nmod|END_ENTITY	Actin-binding_protein-280 binds the stress-activated_protein_kinase -LRB- SAPK -RRB- activator SEK-1 and is required for tumor_necrosis_factor-alpha activation of SAPK in melanoma cells .
11749970	0	tumor_necrosis_factor-alpha	106,133	SCYA20	63,69	tumor necrosis factor-alpha	SCYA20	7124	6364	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Human macrophage_inflammatory_protein-3alpha / CCL20/LARC/Exodus / SCYA20 is transcriptionally upregulated by tumor_necrosis_factor-alpha via a non-standard NF-kappaB site .
11777919	0	tumor_necrosis_factor-alpha	53,80	Sphingosine_kinase	0,18	tumor necrosis factor-alpha	Sphingosine kinase	7124	8877	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Sphingosine_kinase interacts with TRAF2 and dissects tumor_necrosis_factor-alpha signaling .
20544543	0	tumor_necrosis_factor-alpha	100,127	Stat1	14,19	tumor necrosis factor-alpha	Stat1	7124	6772	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of Stat1 , IRF-1 , and NF-kappaB is required for the induction of uridine phosphorylase by tumor_necrosis_factor-alpha and interferon-gamma .
16260783	0	tumor_necrosis_factor-alpha	25,52	TAK1	0,4	tumor necrosis factor-alpha	TAK1	7124	6885	Gene	Gene	recruited|nmod|START_ENTITY recruited|nsubjpass|END_ENTITY	TAK1 is recruited to the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- _ receptor_1 complex in a receptor-interacting_protein -LRB- RIP -RRB- - dependent manner and cooperates with MEKK3 leading to NF-kappaB activation .
17927494	0	tumor_necrosis_factor-alpha	9,36	TAZ	48,51	tumor necrosis factor-alpha	TAZ	7124	6901	Gene	Gene	suppresses|amod|START_ENTITY END_ENTITY|nsubj|suppresses	Elevated tumor_necrosis_factor-alpha suppresses TAZ expression and impairs osteogenic potential of Flk-1 + mesenchymal stem cells in patients with multiple_myeloma .
12161343	0	tumor_necrosis_factor-alpha	19,46	TNF	48,51	tumor necrosis factor-alpha	TNF	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY involvement|appos|END_ENTITY	The involvement of tumor_necrosis_factor-alpha -LRB- TNF -RRB- as an intraovarian regulator of oocyte apoptosis in the neonatal rat .
7843077	0	tumor_necrosis_factor-alpha	14,41	TNF	43,46	tumor necrosis factor-alpha	TNF	7124	7124	Gene	Gene	Evaluation|nmod|START_ENTITY Evaluation|appos|END_ENTITY	Evaluation of tumor_necrosis_factor-alpha -LRB- TNF -RRB- as an exposure or risk marker in three French coal mining regions .
15353169	0	tumor_necrosis_factor-alpha	18,45	TNF-R1	58,64	tumor necrosis factor-alpha	TNF-R1	7124	7132	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Ethanol increases tumor_necrosis_factor-alpha receptor-1 -LRB- TNF-R1 -RRB- levels in hepatic , intestinal , and cardiac cells .
21850623	0	tumor_necrosis_factor-alpha	20,47	TNF-a	49,54	tumor necrosis factor-alpha	TNF-a	7124	7124	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Plasma visfatin and tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- levels in metabolic_syndrome .
23032984	0	tumor_necrosis_factor-alpha	61,88	TNF-a	90,95	tumor necrosis factor-alpha	TNF-a	7124	7124	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	T-cell_non-Hodgkin 's _ lymphomas reported to the FDA AERS with tumor_necrosis_factor-alpha -LRB- TNF-a -RRB- inhibitors : results of the REFURBISH study .
10463815	0	tumor_necrosis_factor-alpha	17,44	TNF-alpha	46,55	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in serum by a highly sensitive enzyme amplified lanthanide luminescence immunoassay .
10488740	0	tumor_necrosis_factor-alpha	67,94	TNF-alpha	96,105	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Significant association of a single nucleotide polymorphism in the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene promoter with human narcolepsy .
10751892	0	tumor_necrosis_factor-alpha	58,85	TNF-alpha	87,96	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Frequent genotype changes at -308 , and 488 regions of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene in patients with prostate_cancer .
10880890	0	tumor_necrosis_factor-alpha	17,44	TNF-alpha	46,55	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Plasma levels of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- are essentially dependent on visceral fat amount in type 2 diabetic patients .
11457927	0	tumor_necrosis_factor-alpha	12,39	TNF-alpha	41,50	tumor necrosis factor-alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in skeletal muscle regeneration .
11838052	0	tumor_necrosis_factor-alpha	49,76	TNF-alpha	77,86	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Response of keloid fibroblasts to the effect of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
12213594	0	tumor_necrosis_factor-alpha	13,40	TNF-alpha	42,51	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	translocation|amod|START_ENTITY translocation|appos|END_ENTITY	Reduction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- related nuclear_factor-kappaB -LRB- NF-kappaB -RRB- translocation but not inhibitor kappa-B -LRB- Ikappa-B -RRB- - degradation by Rho protein inhibition in human endothelial cells .
12527424	0	tumor_necrosis_factor-alpha	62,89	TNF-alpha	91,100	tumor necrosis factor-alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	converting|amod|START_ENTITY converting|amod|END_ENTITY	Differential expression of plasminogen_activator_inhibitor-1 , tumor_necrosis_factor-alpha , TNF-alpha converting enzyme and ADAMTS family members in murine fat territories .
12657115	0	tumor_necrosis_factor-alpha	50,77	TNF-alpha	79,88	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism at the -308 - promoter position of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene and cervical_cancer .
12871593	0	tumor_necrosis_factor-alpha	13,40	TNF-alpha	42,51	tumor necrosis factor-alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Induction|nmod|START_ENTITY Induction|appos|END_ENTITY	Induction of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- by interleukin-12 p40 monomer and homodimer in microglia and macrophages .
14757367	0	tumor_necrosis_factor-alpha	55,82	TNF-alpha	84,93	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Serum_amyloid_A-induced mRNA expression and release of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in human neutrophils .
15319168	0	tumor_necrosis_factor-alpha	21,48	TNF-alpha	50,59	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Relation between the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene and protein expression , and clinical , biochemical , and genetic markers : age , body mass index and uric_acid are independent predictors for an elevated TNF-alpha plasma level in a complex risk model .
15627647	0	tumor_necrosis_factor-alpha	52,79	TNF-alpha	81,90	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The -308 polymorphism in the promoter region of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene and ex vivo lipopolysaccharide-induced TNF-alpha expression in patients with aggressive_periodontitis and/or type 1 diabetes_mellitus .
16422104	0	tumor_necrosis_factor-alpha	37,64	TNF-alpha	66,75	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Building immune microsphere against tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
16705808	0	tumor_necrosis_factor-alpha	55,82	TNF-alpha	84,93	tumor necrosis factor-alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Diesel exhaust particles induce the over expression of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene in alveolar macrophages and failed to induce apoptosis through activation of nuclear_factor-kappaB -LRB- NF-kappaB -RRB- .
16932925	0	tumor_necrosis_factor-alpha	49,76	TNF-alpha	78,87	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Family and case-control association study of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- gene with schizophrenia and response to antipsychotic medication .
1747479	0	tumor_necrosis_factor-alpha	14,41	TNF-alpha	43,52	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	Synthesis|nmod|START_ENTITY Synthesis|appos|END_ENTITY	-LSB- Synthesis of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- by human monocytes in vitro -RSB- .
17537727	0	tumor_necrosis_factor-alpha	72,99	TNF-alpha	101,110	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
17607964	0	tumor_necrosis_factor-alpha	229,256	TNF-alpha	258,267	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
18176176	0	tumor_necrosis_factor-alpha	22,49	TNF-alpha	51,60	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Interleukin-6 -LRB- IL-6 -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- levels and IL-6 , TNF-polymorphisms in children with thrombosis .
18510047	0	tumor_necrosis_factor-alpha	15,42	TNF-alpha	44,53	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- on peritoneal fluid mononuclear cells in women with endometriosis -RSB- .
18618248	0	tumor_necrosis_factor-alpha	18,45	TNF-alpha	47,56	tumor necrosis factor-alpha	TNF-alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	The expression of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- by the intrathecal injection of lipopolysaccharide in the rat spinal cord .
18791857	0	tumor_necrosis_factor-alpha	43,70	TNF-alpha	72,81	tumor necrosis factor-alpha	TNF-alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Lipopolysaccharide-induced upregulation of tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in rat spinal cord .
20097764	0	tumor_necrosis_factor-alpha	42,69	TNF-alpha	71,80	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Histone_deacetylase-3 activation promotes tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression in cardiomyocytes during lipopolysaccharide stimulation .
8522236	0	tumor_necrosis_factor-alpha	26,53	TNF-alpha	15,24	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	effect|appos|START_ENTITY effect|nmod|END_ENTITY	-LSB- The effect of TNF-alpha -LRB- tumor_necrosis_factor-alpha -RRB- on progesterone synthesis in vitro by cells from ovarian follicular fluid in women -RSB- .
9355965	0	tumor_necrosis_factor-alpha	39,66	TNF-alpha	68,77	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	DNA polymorphisms and mutations of the tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- promoter in Langerhans_cell_histiocytosis -LRB- LCH -RRB- .
9528902	0	tumor_necrosis_factor-alpha	2,29	TNF-alpha	31,40	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	A tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- promoter polymorphism is associated with chronic hepatitis_B_infection .
9667368	0	tumor_necrosis_factor-alpha	8,35	TNF-alpha	37,46	tumor necrosis factor-alpha	TNF-alpha	7124	7124	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Soluble tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- receptors in human colostrum and milk bind to TNF-alpha and neutralize TNF-alpha bioactivity .
11393654	0	tumor_necrosis_factor-alpha	137,164	TNFA	171,175	tumor necrosis factor-alpha	TNFA	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism -LRB- SNP -RRB- sites in the tumor_necrosis_factor-alpha gene -LRB- TNFA -RRB- promoter .
8275935	0	tumor_necrosis_factor-alpha	14,41	TNF_alpha	88,97	tumor necrosis factor-alpha	TNF alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|amod|START_ENTITY effect|nmod|END_ENTITY	Expression of tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- receptors and selective effect of TNF_alpha on the inner cell mass in mouse blastocysts .
8837058	0	tumor_necrosis_factor-alpha	34,61	TNF_alpha	63,72	tumor necrosis factor-alpha	TNF alpha	100009088(Tax:9986)	100009088(Tax:9986)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Preliminary morphometric study of tumor_necrosis_factor-alpha -LRB- TNF_alpha -RRB- - induced rabbit optic_neuropathy .
10329406	0	tumor_necrosis_factor-alpha	82,109	Thioredoxin	0,11	tumor necrosis factor-alpha	Thioredoxin	21926(Tax:10090)	22166(Tax:10090)	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Thioredoxin negatively regulates p38 MAP kinase activation and IL-6 production by tumor_necrosis_factor-alpha .
15485822	0	tumor_necrosis_factor-alpha	31,58	Toll-like_receptor_9	0,20	tumor necrosis factor-alpha	Toll-like receptor 9	21926(Tax:10090)	81897(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Toll-like_receptor_9 regulates tumor_necrosis_factor-alpha expression by different mechanisms .
17204997	0	tumor_necrosis_factor-alpha	87,114	Transforming_growth_factor-beta1	0,32	tumor necrosis factor-alpha	Transforming growth factor-beta1	7124	7040	Gene	Gene	induced|nmod|START_ENTITY induced|nsubj|blocks blocks|amod|END_ENTITY	Transforming_growth_factor-beta1 blocks in vitro cardiac myocyte depression induced by tumor_necrosis_factor-alpha , interleukin-1beta , and human septic_shock serum .
9848725	0	tumor_necrosis_factor-alpha	73,100	Transforming_growth_factor-beta1	0,32	tumor necrosis factor-alpha	Transforming growth factor-beta1	7124	7040	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|resistance resistance|amod|END_ENTITY	Transforming_growth_factor-beta1 resistance in a thyroid_cancer model of tumor_necrosis_factor-alpha resistance .
16288471	0	tumor_necrosis_factor-alpha	51,78	VCAM-1	30,36	tumor necrosis factor-alpha	VCAM-1	7124	7412	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Transcriptional regulation of VCAM-1 expression by tumor_necrosis_factor-alpha in human tracheal smooth muscle cells : involvement of MAPKs , NF-kappaB , p300 , and histone acetylation .
9396925	0	tumor_necrosis_factor-alpha	22,49	VCAM-1	168,174	tumor necrosis factor-alpha	VCAM-1	7124	7412	Gene	Gene	Circulating|dobj|START_ENTITY _|advcl|Circulating _|dobj|END_ENTITY	Circulating bioactive tumor_necrosis_factor-alpha , tumor_necrosis_factor-alpha_receptors , _ fibronectin , _ and_tumor_necrosis_factor-alpha inducible cell adhesion molecule VCAM-1 in uncomplicated pregnancy .
17170373	0	tumor_necrosis_factor-alpha	87,114	Vascular_endothelial_growth_factor	0,34	tumor necrosis factor-alpha	Vascular endothelial growth factor	100009088(Tax:9986)	100008899(Tax:9986)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Vascular_endothelial_growth_factor synergistically enhances induction of E-selectin by tumor_necrosis_factor-alpha .
9201618	0	tumor_necrosis_factor-alpha	82,109	Vascular_endothelial_growth_factor	0,34	tumor necrosis factor-alpha	Vascular endothelial growth factor	7124	7422	Gene	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced inhibits|dobj|apoptosis inhibits|nsubj|END_ENTITY	Vascular_endothelial_growth_factor inhibits endothelial cell apoptosis induced by tumor_necrosis_factor-alpha : balance between growth and death signals .
19339243	0	tumor_necrosis_factor-alpha	54,81	WISP1	0,5	tumor necrosis factor-alpha	WISP1	7124	8840	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	WISP1 , a pro-mitogenic , pro-survival factor , mediates tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- - stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte_death .
12818375	0	tumor_necrosis_factor-alpha	16,43	YC-1	58,62	tumor necrosis factor-alpha	YC-1	24835(Tax:10116)	24421(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Potentiation of tumor_necrosis_factor-alpha expression by YC-1 in alveolar macrophages through a cyclic_GMP-independent pathway .
9468519	0	tumor_necrosis_factor-alpha	107,134	activating_protein-1	8,28	tumor necrosis factor-alpha	activating protein-1	7124	3725	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|amod|END_ENTITY	Role of activating_protein-1 in the regulation of the vascular_cell_adhesion_molecule-1 gene expression by tumor_necrosis_factor-alpha .
16254197	0	tumor_necrosis_factor-alpha	56,83	adiponectin	135,146	tumor necrosis factor-alpha	adiponectin	7124	9370	Gene	Gene	gene|amod|START_ENTITY gene|nmod|polymorphism polymorphism|nmod|gene gene|compound|END_ENTITY	Interaction of the -308 G/A promoter polymorphism of the tumor_necrosis_factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene : effect on serum adiponectin concentrations in a Spanish population .
16254197	0	tumor_necrosis_factor-alpha	56,83	adiponectin	169,180	tumor necrosis factor-alpha	adiponectin	7124	9370	Gene	Gene	gene|amod|START_ENTITY polymorphism|nmod|gene Interaction|nmod|polymorphism Interaction|dep|effect effect|nmod|concentrations concentrations|compound|END_ENTITY	Interaction of the -308 G/A promoter polymorphism of the tumor_necrosis_factor-alpha gene with single-nucleotide polymorphism 45 of the adiponectin gene : effect on serum adiponectin concentrations in a Spanish population .
17537727	0	tumor_necrosis_factor-alpha	72,99	adiponectin	50,61	tumor necrosis factor-alpha	adiponectin	7124	9370	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|treatment treatment|nmod|macrophages macrophages|nmod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
18334666	0	tumor_necrosis_factor-alpha	97,124	adiponectin	37,48	tumor necrosis factor-alpha	adiponectin	24835(Tax:10116)	9370	Gene	Gene	cytokines|amod|START_ENTITY decrease|dobj|cytokines decrease|nsubj|increases increases|nmod|END_ENTITY	Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor_necrosis_factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells .
21274300	0	tumor_necrosis_factor-alpha	44,71	adiponectin	148,159	tumor necrosis factor-alpha	adiponectin	7124	9370	Gene	Gene	levels|dep|START_ENTITY relationship|nmod|levels relationship|parataxis|marker marker|nsubj|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
21274300	0	tumor_necrosis_factor-alpha	44,71	adiponectin	31,42	tumor necrosis factor-alpha	adiponectin	7124	9370	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
19026557	0	tumor_necrosis_factor-alpha	79,106	adipose_triglyceride_lipase	4,31	tumor necrosis factor-alpha	adipose triglyceride lipase	21926(Tax:10090)	66853(Tax:10090)	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nsubjpass|END_ENTITY	The adipose_triglyceride_lipase , adiponectin and visfatin are downregulated by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- in vivo .
19087720	0	tumor_necrosis_factor-alpha	12,39	adipose_triglyceride_lipase	70,97	tumor necrosis factor-alpha	adipose triglyceride lipase	21926(Tax:10090)	66853(Tax:10090)	Gene	Gene	resistance|amod|START_ENTITY resistance|nmod|END_ENTITY	-LSB- Effects of tumor_necrosis_factor-alpha induced insulin resistance on adipose_triglyceride_lipase in mice -RSB- .
9045742	0	tumor_necrosis_factor-alpha	42,69	alpha-MSH	0,9	tumor necrosis factor-alpha	alpha-MSH	21926(Tax:10090)	18976(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|modulates modulates|amod|END_ENTITY	alpha-MSH modulates local and circulating tumor_necrosis_factor-alpha in experimental brain_inflammation .
12816950	0	tumor_necrosis_factor-alpha	73,100	alpha-Melanocyte-stimulating_hormone	0,36	tumor necrosis factor-alpha	alpha-Melanocyte-stimulating hormone	7124	5443	Gene	Gene	production|amod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	alpha-Melanocyte-stimulating_hormone inhibits lipopolysaccharide-induced tumor_necrosis_factor-alpha production in leukocytes by modulating protein kinase A , p38 kinase , and nuclear_factor_kappa_B signaling pathways .
17466926	0	tumor_necrosis_factor-alpha	66,93	angiopoietin-1	14,28	tumor necrosis factor-alpha	angiopoietin-1	7124	284	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of angiopoietin-1 in osteoblasts and its inhibition by tumor_necrosis_factor-alpha and interferon-gamma .
14519430	0	tumor_necrosis_factor-alpha	24,51	angiotensin_II	64,78	tumor necrosis factor-alpha	angiotensin II	7124	183	Gene	Gene	promoter|amod|START_ENTITY promoter|nmod|END_ENTITY	Regulation of the human tumor_necrosis_factor-alpha promoter by angiotensin_II and lipopolysaccharide in cardiac fibroblasts : different cis-acting promoter sequences and transcriptional factors .
11798464	0	tumor_necrosis_factor-alpha	31,58	antithrombin_III	11,27	tumor necrosis factor-alpha	antithrombin III	7124	462	Gene	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Effects of antithrombin_III on tumor_necrosis_factor-alpha and interleukin-1beta synthesis in vascular smooth muscle cells .
15302609	0	tumor_necrosis_factor-alpha	76,103	arylsulfatase-A	119,134	tumor necrosis factor-alpha	arylsulfatase-A	7124	410	Gene	Gene	activity|amod|START_ENTITY activity|compound|END_ENTITY	Determination of diagnostic and prognostic values of urinary interleukin-8 , tumor_necrosis_factor-alpha , and leukocyte arylsulfatase-A activity in patients with bladder_cancer .
15837568	0	tumor_necrosis_factor-alpha	75,102	beta-amyloid_precursor_protein	15,45	tumor necrosis factor-alpha	beta-amyloid precursor protein	7124	351	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Antibody-bound beta-amyloid_precursor_protein stimulates the production of tumor_necrosis_factor-alpha and monocyte_chemoattractant_protein-1 by cortical neurons .
18567888	0	tumor_necrosis_factor-alpha	37,64	beta-defensin-2	14,29	tumor necrosis factor-alpha	beta-defensin-2	7124	1673	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of human beta-defensin-2 during tumor_necrosis_factor-alpha / NF-kappaB-mediated innate antiviral response against human_respiratory_syncytial_virus .
12608646	0	tumor_necrosis_factor-alpha	15,42	beta2-adrenoceptor	46,64	tumor necrosis factor-alpha	beta2-adrenoceptor	24835(Tax:10116)	24176(Tax:10116)	Gene	Gene	START_ENTITY|nmod|activation activation|amod|END_ENTITY	Suppression of tumor_necrosis_factor-alpha by beta2-adrenoceptor activation : role of mitogen-activated protein kinases in renal mesangial cells .
15851600	0	tumor_necrosis_factor-alpha	120,147	bone_morphogenetic_protein-2	14,42	tumor necrosis factor-alpha	bone morphogenetic protein-2	7124	650	Gene	Gene	activation|nmod|START_ENTITY role|nmod|activation Regulation|dep|role Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of bone_morphogenetic_protein-2 expression in endothelial cells : role of nuclear factor-kappaB activation by tumor_necrosis_factor-alpha , H2O2 , and high intravascular pressure .
16835229	0	tumor_necrosis_factor-alpha	26,53	bone_morphogenetic_protein-2	62,90	tumor necrosis factor-alpha	bone morphogenetic protein-2	7124	650	Gene	Gene	induces|nsubj|START_ENTITY induces|xcomp|END_ENTITY	Pro-inflammatory cytokine tumor_necrosis_factor-alpha induces bone_morphogenetic_protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation .
18191973	0	tumor_necrosis_factor-alpha	18,45	c-Jun	179,184	tumor necrosis factor-alpha	c-Jun	7124	3725	Gene	Gene	expressions|amod|START_ENTITY inhibits|dobj|expressions inhibits|nmod|suppression suppression|nmod|phosphorylation phosphorylation|amod|END_ENTITY	Ketamine inhibits tumor_necrosis_factor-alpha and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like_receptor_4-mediated c-Jun N-terminal kinase phosphorylation and activator_protein-1 activation .
20219981	0	tumor_necrosis_factor-alpha	65,92	c-Jun_N-terminal_protein_kinase	19,50	tumor necrosis factor-alpha	c-Jun N-terminal protein kinase	7124	5599	Gene	Gene	prevents|nmod|START_ENTITY prevents|dobj|activation activation|amod|END_ENTITY	Exendin-4 prevents c-Jun_N-terminal_protein_kinase activation by tumor_necrosis_factor-alpha -LRB- TNFalpha -RRB- and inhibits TNFalpha-induced apoptosis in insulin-secreting cells .
3402392	0	tumor_necrosis_factor-alpha	11,38	cachectin	39,48	tumor necrosis factor-alpha	cachectin	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of tumor_necrosis_factor-alpha / cachectin on thyroid hormone metabolism in mice .
3495589	0	tumor_necrosis_factor-alpha	21,48	cachectin	49,58	tumor necrosis factor-alpha	cachectin	7124	7124	Gene	Gene	effects|nmod|START_ENTITY effects|dep|END_ENTITY	Disparate effects of tumor_necrosis_factor-alpha / cachectin and tumor_necrosis_factor-beta / lymphotoxin on hematopoietic_growth_factor production and neutrophil adhesion molecule expression by cultured human endothelial cells .
16288025	0	tumor_necrosis_factor-alpha	26,53	chemokine_receptor	64,82	tumor necrosis factor-alpha	chemokine receptor	7124	7852	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|compound|END_ENTITY	The inflammatory cytokine tumor_necrosis_factor-alpha regulates chemokine_receptor expression on ovarian_cancer cells .
10501211	0	tumor_necrosis_factor-alpha	109,136	cyclooxygenase-2	207,223	tumor necrosis factor-alpha	cyclooxygenase-2	7124	5743	Gene	Gene	involved|nmod|START_ENTITY mechanisms|acl|involved mechanisms|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Signaling mechanisms involved in the activation of arachidonic_acid metabolism in human astrocytoma cells by tumor_necrosis_factor-alpha : phosphorylation of cytosolic_phospholipase_A2 and transactivation of cyclooxygenase-2 .
11289153	0	tumor_necrosis_factor-alpha	66,93	cyclooxygenase-2	27,43	tumor necrosis factor-alpha	cyclooxygenase-2	7124	5743	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Differential expression of cyclooxygenase-2 and its regulation by tumor_necrosis_factor-alpha in normal and malignant prostate cells .
12384076	0	tumor_necrosis_factor-alpha	55,82	cyclooxygenase-2	148,164	tumor necrosis factor-alpha	cyclooxygenase-2	7124	5743	Gene	Gene	production|amod|START_ENTITY Modulation|nmod|production associated|nsubjpass|Modulation associated|nmod|expression expression|nummod|END_ENTITY	Modulation of lipopolysaccharide-stimulated macrophage tumor_necrosis_factor-alpha production by omega-3_fatty_acid is associated with differential cyclooxygenase-2 protein expression and is independent of interleukin-10 .
16093422	0	tumor_necrosis_factor-alpha	85,112	cyclooxygenase-2	16,32	tumor necrosis factor-alpha	cyclooxygenase-2	24835(Tax:10116)	29527(Tax:10116)	Gene	Gene	action|nmod|START_ENTITY mediate|dobj|action mediate|nsubj|Upregulation Upregulation|nmod|production production|amod|END_ENTITY	Upregulation of cyclooxygenase-2 and thromboxane_A2 production mediate the action of tumor_necrosis_factor-alpha in isolated rat myenteric ganglia .
19174152	0	tumor_necrosis_factor-alpha	116,143	cyclooxygenase-2	77,93	tumor necrosis factor-alpha	cyclooxygenase-2	21926(Tax:10090)	19225(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor_necrosis_factor-alpha .
9875706	0	tumor_necrosis_factor-alpha	34,61	cyclooxygenase-2	77,93	tumor necrosis factor-alpha	cyclooxygenase-2	24835(Tax:10116)	29527(Tax:10116)	Gene	Gene	slow-wave_sleep|nmod|START_ENTITY Enhancement|nmod|slow-wave_sleep mediated|nsubjpass|Enhancement mediated|nmod|END_ENTITY	Enhancement of slow-wave_sleep by tumor_necrosis_factor-alpha is mediated by cyclooxygenase-2 in rats .
10501211	0	tumor_necrosis_factor-alpha	109,136	cytosolic_phospholipase_A2	157,183	tumor necrosis factor-alpha	cytosolic phospholipase A2	7124	5321	Gene	Gene	involved|nmod|START_ENTITY mechanisms|acl|involved mechanisms|dep|phosphorylation phosphorylation|nmod|END_ENTITY	Signaling mechanisms involved in the activation of arachidonic_acid metabolism in human astrocytoma cells by tumor_necrosis_factor-alpha : phosphorylation of cytosolic_phospholipase_A2 and transactivation of cyclooxygenase-2 .
7726846	0	tumor_necrosis_factor-alpha	169,196	cytosolic_phospholipase_A2	105,131	tumor necrosis factor-alpha	cytosolic phospholipase A2	7124	5321	Gene	Gene	stimulated|nmod|START_ENTITY neutrophils|acl|stimulated involved|nmod|neutrophils involved|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	A mitogen-activated protein kinase independent pathway involved in the phosphorylation and activation of cytosolic_phospholipase_A2 in human neutrophils stimulated with tumor_necrosis_factor-alpha .
11254538	0	tumor_necrosis_factor-alpha	66,93	early_growth-response_factor_1	25,55	tumor necrosis factor-alpha	early growth-response factor 1	21926(Tax:10090)	13653(Tax:10090)	Gene	Gene	modulates|dobj|START_ENTITY modulates|nsubj|END_ENTITY	The transcription factor early_growth-response_factor_1 modulates tumor_necrosis_factor-alpha , immunoglobulin E , and airway responsiveness in mice .
12218613	0	tumor_necrosis_factor-alpha	39,66	epidermal_growth_factor	14,37	tumor necrosis factor-alpha	epidermal growth factor	7124	1950	Gene	Gene	START_ENTITY|nsubj|Expression Expression|nmod|END_ENTITY	Expression of epidermal_growth_factor , tumor_necrosis_factor-alpha , and interleukin-1alpha in chronic_otitis_media with or without cholesteatoma .
17607964	0	tumor_necrosis_factor-alpha	229,256	erythropoietin	18,32	tumor necrosis factor-alpha	erythropoietin	7124	2056	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|csubj|-LSB- -LSB-|dobj|influence influence|nmod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
18399174	0	tumor_necrosis_factor-alpha	14,41	erythropoietin	66,80	tumor necrosis factor-alpha	erythropoietin	7124	2056	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|production production|compound|END_ENTITY	-LSB- Influence of tumor_necrosis_factor-alpha and interferon-gamma on erythropoietin production and erythropoiesis in cancer patients with anemia -RSB- .
2303102	0	tumor_necrosis_factor-alpha	41,68	erythropoietin	106,120	tumor necrosis factor-alpha	erythropoietin	21926(Tax:10090)	13856(Tax:10090)	Gene	Gene	erythropoiesis|nmod|START_ENTITY suppression|nmod|erythropoiesis reversal|nmod|suppression reversal|nmod|END_ENTITY	In vivo suppression of erythropoiesis by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- : reversal with exogenous erythropoietin -LRB- EPO -RRB- .
17202889	0	tumor_necrosis_factor-alpha	8,35	focal_adhesion_kinase	77,98	tumor necrosis factor-alpha	focal adhesion kinase	7124	5747	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Role of tumor_necrosis_factor-alpha , interleukin-8 , and dexamethasone in the focal_adhesion_kinase expression by human nucleus pulposus cells .
11311510	0	tumor_necrosis_factor-alpha	28,55	fractalkine	81,92	tumor necrosis factor-alpha	fractalkine	7124	6376	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|nmod|expression expression|amod|END_ENTITY	Synergistic stimulation , by tumor_necrosis_factor-alpha and interferon-gamma , of fractalkine expression in human astrocytes .
16601113	0	tumor_necrosis_factor-alpha	85,112	glycogen_synthase_kinase-3beta	33,63	tumor necrosis factor-alpha	glycogen synthase kinase-3beta	21926(Tax:10090)	56637(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY END_ENTITY|nmod|inhibition	Novel anti-inflammatory role for glycogen_synthase_kinase-3beta in the inhibition of tumor_necrosis_factor-alpha - and interleukin-1beta-induced inflammatory gene expression .
16873189	0	tumor_necrosis_factor-alpha	72,99	gp120	58,63	tumor necrosis factor-alpha	gp120	7124	3700	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Human_immunodeficiency_virus_type_1 envelope glycoprotein gp120 induces tumor_necrosis_factor-alpha in astrocytes .
7704970	0	tumor_necrosis_factor-alpha	95,122	gp120	21,26	tumor necrosis factor-alpha	gp120	7124	155971(Tax:11676)	Gene	Gene	production|compound|START_ENTITY requirements|nmod|production Interaction|dep|requirements Interaction|nmod|fragments fragments|amod|END_ENTITY	Interaction of HIV-1 gp120 molecule fragments with human monocytes : different requirements for tumor_necrosis_factor-alpha and IL-6 production .
1709645	0	tumor_necrosis_factor-alpha	14,41	granulocyte-macrophage_colony-stimulating_factor	81,129	tumor necrosis factor-alpha	granulocyte-macrophage colony-stimulating factor	7124	1437	Gene	Gene	START_ENTITY|nmod|production production|nmod|END_ENTITY	Modulation by tumor_necrosis_factor-alpha of human astroglial cell production of granulocyte-macrophage_colony-stimulating_factor -LRB- GM-CSF -RRB- and granulocyte_colony-stimulating_factor -LRB- G-CSF -RRB- .
1915559	0	tumor_necrosis_factor-alpha	102,129	granulocyte-macrophage_colony-stimulating_factor	14,62	tumor necrosis factor-alpha	granulocyte-macrophage colony-stimulating factor	7124	1437	Gene	Gene	regulation|nmod|START_ENTITY Expression|dep|regulation Expression|nmod|END_ENTITY	Expression of granulocyte-macrophage_colony-stimulating_factor in rheumatoid_arthritis : regulation by tumor_necrosis_factor-alpha .
19590023	0	tumor_necrosis_factor-alpha	11,38	granulocyte-macrophage_colony-stimulating_factor	72,120	tumor necrosis factor-alpha	granulocyte-macrophage colony-stimulating factor	21926(Tax:10090)	12981(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	Macrophage tumor_necrosis_factor-alpha induces epithelial expression of granulocyte-macrophage_colony-stimulating_factor : impact on alveolar epithelial repair .
7541223	0	tumor_necrosis_factor-alpha	72,99	granulocyte_colony-stimulating_factor	25,62	tumor necrosis factor-alpha	granulocyte colony-stimulating factor	7124	1440	Gene	Gene	release|amod|START_ENTITY suppress|dobj|release suppress|nsubj|Neutrophils Neutrophils|acl|activated activated|nmod|END_ENTITY	Neutrophils activated by granulocyte_colony-stimulating_factor suppress tumor_necrosis_factor-alpha release from monocytes stimulated by endotoxin .
8551973	0	tumor_necrosis_factor-alpha	14,41	granulocyte_colony-stimulating_factor	120,157	tumor necrosis factor-alpha	granulocyte colony-stimulating factor	21926(Tax:10090)	12985(Tax:10090)	Gene	Gene	Production|nmod|START_ENTITY Production|nmod|END_ENTITY	Production of tumor_necrosis_factor-alpha in granulocytopenic mice with pulmonary_candidiasis and its modification with granulocyte_colony-stimulating_factor .
9773833	0	tumor_necrosis_factor-alpha	76,103	granulocyte_colony-stimulating_factor	37,74	tumor necrosis factor-alpha	granulocyte colony-stimulating factor	7124	1440	Gene	Gene	_|amod|START_ENTITY _|amod|END_ENTITY	Plasma levels and gene expression of granulocyte_colony-stimulating_factor , tumor_necrosis_factor-alpha , interleukin _ -LRB- IL -RRB- -1 beta , IL-6 , IL-8 , and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis .
9588867	0	tumor_necrosis_factor-alpha	41,68	hTNFalpha	70,79	tumor necrosis factor-alpha	hTNFalpha	7124	7124	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	In vitro and in vivo evaluation of human tumor_necrosis_factor-alpha -LRB- hTNFalpha -RRB- chemically conjugated to monoclonal antibody .
9530200	0	tumor_necrosis_factor-alpha	10,37	heme_oxygenase-1	65,81	tumor necrosis factor-alpha	heme oxygenase-1	7124	3162	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|amod|END_ENTITY	Effect of tumor_necrosis_factor-alpha and interleukin-1_alpha on heme_oxygenase-1 expression in human endothelial cells .
12397608	0	tumor_necrosis_factor-alpha	116,143	inducible_nitric_oxide_synthase	145,176	tumor necrosis factor-alpha	inducible nitric oxide synthase	7124	4843	Gene	Gene	c-myc|compound|START_ENTITY c-myc|dep|END_ENTITY	Hydrostatic_pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor_necrosis_factor-alpha , inducible_nitric_oxide_synthase , p53 , c-myc , and bax-alpha , and suppression of bcl-2 .
8895324	0	tumor_necrosis_factor-alpha	85,112	insulin-like_growth_factor-I	29,57	tumor necrosis factor-alpha	insulin-like growth factor-I	7124	3479	Gene	Gene	production|amod|START_ENTITY effect|nmod|production effect|nmod|END_ENTITY	Direct stimulatory effect of insulin-like_growth_factor-I on monocyte and macrophage tumor_necrosis_factor-alpha production .
10407627	0	tumor_necrosis_factor-alpha	9,36	intercellular_adhesion_molecule-1	87,120	tumor necrosis factor-alpha	intercellular adhesion molecule-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	factor-beta|compound|START_ENTITY factor-beta|acl|regulating regulating|dobj|expression expression|amod|END_ENTITY	Roles of tumor_necrosis_factor-alpha and transforming growth factor-beta in regulating intercellular_adhesion_molecule-1 expression on murine peritoneal macrophages infected with M. _ leprae .
10860946	0	tumor_necrosis_factor-alpha	18,45	intercellular_adhesion_molecule-1	130,163	tumor necrosis factor-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	receptor-1|amod|START_ENTITY Activation|nmod|receptor-1 necrosis|nsubj|Activation necrosis|dobj|expression expression|amod|END_ENTITY	Activation of p55 tumor_necrosis_factor-alpha receptor-1 coupled to tumor necrosis factor receptor-associated factor 2 stimulates intercellular_adhesion_molecule-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle cells .
17607964	0	tumor_necrosis_factor-alpha	229,256	intercellular_adhesion_molecule-1	42,75	tumor necrosis factor-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	-RSB-|amod|START_ENTITY induced|nmod|-RSB- induced|csubj|-LSB- -LSB-|nmod|END_ENTITY	-LSB- The influence of erythropoietin -LRB- Epo -RRB- on intercellular_adhesion_molecule-1 -LRB- ICAM-1 , CD54 -RRB- and platelet-endothelial_cell_adhesion_molecule-1 -LRB- PECAM-1 , CD31 -RRB- expression on human umbilical vein endothelial cells -LRB- HUVEC -RRB- induced by tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- -RSB- .
20045926	0	tumor_necrosis_factor-alpha	93,120	intercellular_adhesion_molecule-1	48,81	tumor necrosis factor-alpha	intercellular adhesion molecule-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Deoxypodophyllotoxin inhibits the expression of intercellular_adhesion_molecule-1 induced by tumor_necrosis_factor-alpha in murine lung epithelial cells .
7910170	0	tumor_necrosis_factor-alpha	67,94	intercellular_adhesion_molecule-1	14,47	tumor necrosis factor-alpha	intercellular adhesion molecule-1	24835(Tax:10116)	25464(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|expression expression|amod|END_ENTITY	Regulation of intercellular_adhesion_molecule-1 gene expression by tumor_necrosis_factor-alpha , interleukin-1_beta , and interferon-gamma in astrocytes .
7915264	0	tumor_necrosis_factor-alpha	21,48	intercellular_adhesion_molecule-1	172,205	tumor necrosis factor-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	increases|nsubj|START_ENTITY increases|nmod|lysis lysis|dep|expression expression|nmod|cells cells|amod|END_ENTITY	Transfection-induced tumor_necrosis_factor-alpha increases the susceptibility of human glioma cells to lysis by lymphokine-activated killer cells : continuous expression of intercellular_adhesion_molecule-1 on the glioma cells .
7930472	0	tumor_necrosis_factor-alpha	104,131	intercellular_adhesion_molecule-1	58,91	tumor necrosis factor-alpha	intercellular adhesion molecule-1	24835(Tax:10116)	25464(Tax:10116)	Gene	Gene	stimulation|amod|START_ENTITY rat|nmod|stimulation rat|dobj|cells cells|amod|END_ENTITY	Cultured rat hepatic sinusoidal endothelial cells express intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- by tumor_necrosis_factor-alpha or interleukin-1_alpha stimulation .
8102141	0	tumor_necrosis_factor-alpha	40,67	intercellular_adhesion_molecule-1	103,136	tumor necrosis factor-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	mediated|nsubj|START_ENTITY mediated|dobj|induction induction|nmod|expression expression|amod|END_ENTITY	Histamine and cis-urocanic_acid augment tumor_necrosis_factor-alpha mediated induction of keratinocyte intercellular_adhesion_molecule-1 expression .
9056676	0	tumor_necrosis_factor-alpha	56,83	intercellular_adhesion_molecule-1	14,47	tumor necrosis factor-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	Regulation of intercellular_adhesion_molecule-1 gene by tumor_necrosis_factor-alpha is mediated by the nuclear factor-kappaB heterodimers p65/p65 and p65/c-Rel in the absence of p50 .
9886187	0	tumor_necrosis_factor-alpha	97,124	intercellular_adhesion_molecule-1	39,72	tumor necrosis factor-alpha	intercellular adhesion molecule-1	21926(Tax:10090)	15894(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|levels levels|amod|END_ENTITY	Correlation of increased expression of intercellular_adhesion_molecule-1 , but not high levels of tumor_necrosis_factor-alpha , with lethality of Plasmodium_yoelii 17XL , a rodent model of cerebral_malaria .
9919421	0	tumor_necrosis_factor-alpha	125,152	intercellular_adhesion_molecule-1	14,47	tumor necrosis factor-alpha	intercellular adhesion molecule-1	7124	3383	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of intercellular_adhesion_molecule-1 in human coronary endothelial and smooth muscle cells after stimulation with tumor_necrosis_factor-alpha .
10865190	0	tumor_necrosis_factor-alpha	13,40	interferon-gamma	137,153	tumor necrosis factor-alpha	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	synthase|compound|START_ENTITY Induction|nmod|synthase fails|nsubj|Induction fails|xcomp|prevent prevent|nmod|absence absence|nmod|END_ENTITY	Induction of tumor_necrosis_factor-alpha and inducible nitric_oxide synthase fails to prevent toxoplasmic_encephalitis in the absence of interferon-gamma in genetically resistant BALB/c mice .
11830590	0	tumor_necrosis_factor-alpha	17,44	interferon-gamma	63,79	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	role|nmod|START_ENTITY role|nmod|END_ENTITY	Critical role of tumor_necrosis_factor-alpha and NF-kappa_B in interferon-gamma - induced CD40 expression in microglia/macrophages .
12788307	0	tumor_necrosis_factor-alpha	98,125	interferon-gamma	33,49	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|production production|nmod|END_ENTITY	Prolactin enhances production of interferon-gamma , interleukin-12 , and interleukin-10 , but not of tumor_necrosis_factor-alpha , in a stimulus-specific manner .
1281560	0	tumor_necrosis_factor-alpha	22,49	interferon-gamma	51,67	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	expression|nmod|START_ENTITY biopsies|nmod|expression biopsies|nsubj|END_ENTITY	In situ expression of tumor_necrosis_factor-alpha , interferon-gamma , and interleukin-2 receptors in renal allograft biopsies .
14602203	0	tumor_necrosis_factor-alpha	49,76	interferon-gamma	138,154	tumor necrosis factor-alpha	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY Active|dobj|induction Active|dobj|modulation modulation|nmod|END_ENTITY	Active and inactive influenza virus induction of tumor_necrosis_factor-alpha and nitric_oxide in J774 .1 murine macrophages : modulation by interferon-gamma and failure to induce apoptosis .
2107993	0	tumor_necrosis_factor-alpha	50,77	interferon-gamma	107,123	tumor necrosis factor-alpha	interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	Enhancement|nmod|START_ENTITY Enhancement|nmod|END_ENTITY	Enhancement of experimental metastatic ability by tumor_necrosis_factor-alpha alone or in combination with interferon-gamma .
2121884	0	tumor_necrosis_factor-alpha	144,171	interferon-gamma	8,24	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	production|nmod|START_ENTITY counteracting|nmod|production END_ENTITY|acl|counteracting	Role of interferon-gamma in counteracting the suppressive effects of transforming_growth_factor-beta_2 and glucocorticoids on the production of tumor_necrosis_factor-alpha .
2143498	0	tumor_necrosis_factor-alpha	113,140	interferon-gamma	91,107	tumor necrosis factor-alpha	interferon-gamma	7124	15978(Tax:10090)	Gene	Gene	synergistically|amod|START_ENTITY mice|dep|synergistically mice|amod|END_ENTITY	Myelopoiesis-associated suppressor-cell activity in mice with Lewis_lung_carcinoma tumors : interferon-gamma plus tumor_necrosis_factor-alpha synergistically reduce suppressor cell activity .
22507322	0	tumor_necrosis_factor-alpha	116,143	interferon-gamma	54,70	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	monocytes|amod|START_ENTITY percentages|dep|monocytes percentages|dep|-LSB- -LSB-|compound|END_ENTITY	Increased percentages of tumor_necrosis_factor-alpha + / interferon-gamma + T -LSB- corrected -RSB- lymphocytes and calprotectin + / tumor_necrosis_factor-alpha + monocytes in patients with acute Kawasaki_disease .
22507322	0	tumor_necrosis_factor-alpha	25,52	interferon-gamma	54,70	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	+|amod|START_ENTITY percentages|nmod|+ percentages|dep|-LSB- -LSB-|compound|END_ENTITY	Increased percentages of tumor_necrosis_factor-alpha + / interferon-gamma + T -LSB- corrected -RSB- lymphocytes and calprotectin + / tumor_necrosis_factor-alpha + monocytes in patients with acute Kawasaki_disease .
2455573	0	tumor_necrosis_factor-alpha	149,176	interferon-gamma	211,227	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	stimulating|nmod|START_ENTITY colony|acl|stimulating Enhancement|nmod|colony Enhancement|dep|synergism synergism|nmod|END_ENTITY	Enhancement of release from MHC class II antigen-positive monocytes of hematopoietic colony stimulating factors CSF-1 and G-CSF by recombinant human tumor_necrosis_factor-alpha : synergism with recombinant human interferon-gamma .
2502555	0	tumor_necrosis_factor-alpha	13,40	interferon-gamma	146,162	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of tumor_necrosis_factor-alpha on the modulation by interferon-gamma of HLA class II molecules in human thyroid cells and its effect on interferon-gamma binding .
2502555	0	tumor_necrosis_factor-alpha	13,40	interferon-gamma	62,78	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of tumor_necrosis_factor-alpha on the modulation by interferon-gamma of HLA class II molecules in human thyroid cells and its effect on interferon-gamma binding .
3138311	0	tumor_necrosis_factor-alpha	45,72	interferon-gamma	126,142	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	effects|nmod|START_ENTITY effects|dep|synergism synergism|nmod|END_ENTITY	The suppressive effects of recombinant human tumor_necrosis_factor-alpha on normal and malignant myelopoiesis : synergism with interferon-gamma .
7549119	0	tumor_necrosis_factor-alpha	17,44	interferon-gamma	74,90	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	Efficacy|nmod|START_ENTITY associated|nsubj|Efficacy associated|nmod|END_ENTITY	-LSB- Efficacy of the tumor_necrosis_factor-alpha -LRB- rTNF-alpha -RRB- associated with interferon-gamma and chemotherapy in extracorporeal circulation in the limb in inoperable malignant_melanoma , soft tissue sarcoma and epidermoid_carcinoma .
8874324	0	tumor_necrosis_factor-alpha	39,66	interferon-gamma	87,103	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	START_ENTITY|nmod|combination combination|nmod|END_ENTITY	Isolated limb perfusion with high-dose tumor_necrosis_factor-alpha in combination with interferon-gamma and melphalan for nonresectable extremity_soft_tissue_sarcomas : a multicenter trial .
8972008	0	tumor_necrosis_factor-alpha	121,148	interferon-gamma	77,93	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	treated|nmod|START_ENTITY treated|nmod|END_ENTITY	Augmented procoagulant activity in cancer patients , treated with recombinant interferon-gamma in addition to recombinant tumor_necrosis_factor-alpha and melphalan .
9550262	0	tumor_necrosis_factor-alpha	93,120	interferon-gamma	178,194	tumor necrosis factor-alpha	interferon-gamma	7124	3458	Gene	Gene	response|amod|START_ENTITY distinct|nmod|response element|amod|distinct promoter|appos|element element|nmod|promoter mediates|nsubj|element mediates|nmod|END_ENTITY	A proximal element within the human alpha_2 -LRB- I -RRB- _ collagen -LRB- COL1A2 -RRB- promoter , distinct from the tumor_necrosis_factor-alpha response element , mediates transcriptional repression by interferon-gamma .
10547095	0	tumor_necrosis_factor-alpha	49,76	interleukin-10	26,40	tumor necrosis factor-alpha	interleukin-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	production|amod|START_ENTITY reduces|dobj|production reduces|nsubj|END_ENTITY	Systemically administered interleukin-10 reduces tumor_necrosis_factor-alpha production and significantly improves functional recovery following traumatic spinal_cord_injury in rats .
10614840	0	tumor_necrosis_factor-alpha	106,133	interleukin-10	71,85	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	association|nmod|START_ENTITY END_ENTITY|nmod|association	Anti-inflammatory cytokine profile in human heart_failure : behavior of interleukin-10 in association with tumor_necrosis_factor-alpha .
10798783	0	tumor_necrosis_factor-alpha	31,58	interleukin-10	60,74	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	The effect of polymorphisms in tumor_necrosis_factor-alpha , interleukin-10 , and transforming_growth_factor-beta1 genes in acute hepatic allograft rejection .
11546981	0	tumor_necrosis_factor-alpha	21,48	interleukin-10	113,127	tumor necrosis factor-alpha	interleukin-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY mediated|nsubjpass|effect mediated|advcl|END_ENTITY	Protective effect of tumor_necrosis_factor-alpha against subsequent endotoxemia in mice is mediated , in part , by interleukin-10 .
11727843	0	tumor_necrosis_factor-alpha	38,65	interleukin-10	22,36	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Longitudinal study of interleukin-10 , tumor_necrosis_factor-alpha , anti-U1-snRNP antibody levels and disease activity in patients with mixed_connective_tissue_disease .
12161227	0	tumor_necrosis_factor-alpha	46,73	interleukin-10	10,24	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	production|nmod|START_ENTITY END_ENTITY|nmod|production	Effect of interleukin-10 on the production of tumor_necrosis_factor-alpha by peripheral blood mononuclear cells from patients with chronic_heart_failure .
14668613	0	tumor_necrosis_factor-alpha	26,53	interleukin-10	97,111	tumor necrosis factor-alpha	interleukin-10	397086(Tax:9823)	397106(Tax:9823)	Gene	Gene	synthesis|nmod|START_ENTITY inhibited|nsubj|synthesis inhibited|nmod|END_ENTITY	Intrahepatic synthesis of tumor_necrosis_factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase -LRB- Jak -RRB- / signal transducers and activator of transcription -LRB- STAT -RRB- pathway .
15100460	0	tumor_necrosis_factor-alpha	39,66	interleukin-10	68,82	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Ethnic differences in polymorphisms of tumor_necrosis_factor-alpha , interleukin-10 , and transforming_growth_factor-beta1 genes in patients with chronic_hepatitis_C_virus_infection .
15331655	0	tumor_necrosis_factor-alpha	84,111	interleukin-10	168,182	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	independent|amod|START_ENTITY independent|nmod|increase increase|nmod|END_ENTITY	Methylenedioxymethamphetamine suppresses production of the proinflammatory cytokine tumor_necrosis_factor-alpha independent of a beta-adrenoceptor-mediated increase in interleukin-10 .
17099512	0	tumor_necrosis_factor-alpha	87,114	interleukin-10	135,149	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	Protective effects of heme-oxygenase expression against endotoxic_shock : inhibition of tumor_necrosis_factor-alpha and augmentation of interleukin-10 .
17209781	0	tumor_necrosis_factor-alpha	12,39	interleukin-10	74,88	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	Analysis|nmod|START_ENTITY transforming|nsubj|Analysis transforming|dobj|factor-beta factor-beta|amod|IL-6 IL-6|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , transforming growth factor-beta , interleukin-10 , IL-6 , and interferon-gamma gene polymorphisms in patients with chronic_periodontitis .
17537727	0	tumor_necrosis_factor-alpha	72,99	interleukin-10	211,225	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nmod|production production|amod|END_ENTITY	Short-term treatment of RAW264 .7 macrophages with adiponectin increases tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- expression via ERK1/2 activation and Egr-1 expression : role of TNF-alpha in adiponectin-stimulated interleukin-10 production .
18787467	0	tumor_necrosis_factor-alpha	133,160	interleukin-10	115,129	tumor necrosis factor-alpha	interleukin-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY END_ENTITY|nmod|ratio	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
18787467	0	tumor_necrosis_factor-alpha	18,45	interleukin-10	115,129	tumor necrosis factor-alpha	interleukin-10	24835(Tax:10116)	25325(Tax:10116)	Gene	Gene	ratio|amod|START_ENTITY Interleukin-10|nmod|ratio biomarker|nsubj|Interleukin-10 biomarker|nmod|fatty_liver_disease fatty_liver_disease|amod|END_ENTITY	Interleukin-10 to tumor_necrosis_factor-alpha ratio is a predictive biomarker in nonalcoholic fatty_liver_disease : interleukin-10 to tumor_necrosis_factor-alpha ratio in steatohepatitis .
19817985	0	tumor_necrosis_factor-alpha	90,117	interleukin-10	74,88	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	genes|amod|START_ENTITY development|dep|genes polymorphisms|dep|development polymorphisms|nmod|class class|amod|END_ENTITY	Impact of polymorphisms of the major histocompatibility complex class II , interleukin-10 , tumor_necrosis_factor-alpha and cytotoxic_T-lymphocyte_antigen-4 genes on inhibitor development in severe hemophilia_A . .
20163933	0	tumor_necrosis_factor-alpha	32,59	interleukin-10	61,75	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	cluster|amod|START_ENTITY cluster|amod|END_ENTITY	Polymorphisms of genes encoding tumor_necrosis_factor-alpha , interleukin-10 , cluster of differentiation-14 and interleukin-1ra in critically_ill patients .
20684180	0	tumor_necrosis_factor-alpha	111,138	interleukin-10	12,26	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	patients|nmod|START_ENTITY mortality|nmod|patients association|nmod|mortality END_ENTITY|dep|association	Circulating interleukin-10 : association with higher mortality in systolic heart_failure patients with elevated tumor_necrosis_factor-alpha .
7542295	0	tumor_necrosis_factor-alpha	36,63	interleukin-10	82,96	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	expression|nmod|START_ENTITY Up-regulation|nmod|expression neutralized|nsubjpass|Up-regulation neutralized|nmod|cells cells|amod|END_ENTITY	Up-regulation of CD44 expression by tumor_necrosis_factor-alpha is neutralized by interleukin-10 in Langerhans cells .
7589088	0	tumor_necrosis_factor-alpha	70,97	interleukin-10	27,41	tumor necrosis factor-alpha	interleukin-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Lipopolysaccharide-induced interleukin-10 in mice : role of endogenous tumor_necrosis_factor-alpha .
7590660	0	tumor_necrosis_factor-alpha	53,80	interleukin-10	27,41	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	overproduction|amod|START_ENTITY release|nmod|overproduction release|amod|END_ENTITY	Role of defective monocyte interleukin-10 release in tumor_necrosis_factor-alpha overproduction in alcoholics cirrhosis .
8865287	0	tumor_necrosis_factor-alpha	126,153	interleukin-10	10,24	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	production|nmod|START_ENTITY relationship|nmod|production production|dep|relationship production|amod|END_ENTITY	Decreased interleukin-10 production by neonatal monocytes and T cells : relationship to decreased production and expression of tumor_necrosis_factor-alpha and its receptors .
9063693	0	tumor_necrosis_factor-alpha	15,42	interleukin-10	57,71	tumor necrosis factor-alpha	interleukin-10	7124	3586	Gene	Gene	production|amod|START_ENTITY production|nmod|END_ENTITY	Suppression of tumor_necrosis_factor-alpha production by interleukin-10 is enhanced by cAMP-elevating agents .
9420870	0	tumor_necrosis_factor-alpha	45,72	interleukin-1_alpha	24,43	tumor necrosis factor-alpha	interleukin-1 alpha	7124	3552	Gene	Gene	hydrocortisone|dep|START_ENTITY hydrocortisone|compound|END_ENTITY	Differential effects of interleukin-1_alpha , tumor_necrosis_factor-alpha , indomethacin , hydrocortisone , and macrophage co-culture on the proliferation of human fibroblasts and peritoneal mesothelial cells .
9751191	0	tumor_necrosis_factor-alpha	48,75	interleukin-1_alpha	77,96	tumor necrosis factor-alpha	interleukin-1 alpha	21926(Tax:10090)	16175(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|amod|END_ENTITY	Cellular localization and temporal elevation of tumor_necrosis_factor-alpha , interleukin-1_alpha , and transforming_growth_factor-beta_1 mRNA in hippocampal_injury response induced by trimethyltin .
14611111	0	tumor_necrosis_factor-alpha	93,120	interleukin-1_beta	122,140	tumor necrosis factor-alpha	interleukin-1 beta	7124	3553	Gene	Gene	exposure|nmod|START_ENTITY exposure|amod|END_ENTITY	Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor_necrosis_factor-alpha , interleukin-1_beta and cholecystokinin-8 : the possible role of NGF in the inflammatory response .
1490727	0	tumor_necrosis_factor-alpha	48,75	interleukin-1_beta	87,105	tumor necrosis factor-alpha	interleukin-1 beta	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	down-regulation|nmod|START_ENTITY release|nsubj|down-regulation release|advcl|END_ENTITY	Indirect and selective down-regulation of serum tumor_necrosis_factor-alpha release by interleukin-1_beta .
2121675	0	tumor_necrosis_factor-alpha	101,128	interleukin-1_beta	38,56	tumor necrosis factor-alpha	interleukin-1 beta	7124	3553	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Antitumor effect of recombinant human interleukin-1_beta alone and in combination with natural human tumor_necrosis_factor-alpha .
8380885	0	tumor_necrosis_factor-alpha	14,41	interleukin-1_beta	43,61	tumor necrosis factor-alpha	interleukin-1 beta	7124	3553	Gene	Gene	expression|amod|START_ENTITY expression|amod|_ _|dep|END_ENTITY	Modulation of tumor_necrosis_factor-alpha , interleukin-1_beta , interleukin-6 , interleukin-8 , and granulocyte/macrophage _ colony-stimulating_factor expression in human monocytes by an endogenous anxiogenic benzodiazepine ligand , triakontatetraneuropeptide : evidence for a role of prostaglandins .
8865966	0	tumor_necrosis_factor-alpha	77,104	interleukin-1_beta	106,124	tumor necrosis factor-alpha	interleukin-1 beta	7124	3553	Gene	Gene	START_ENTITY|appos|interleukin-10 interleukin-10|amod|END_ENTITY	Regulation of human monocyte functions by acute ethanol treatment : decreased tumor_necrosis_factor-alpha , interleukin-1_beta and elevated interleukin-10 , and transforming_growth_factor-beta production .
9051688	0	tumor_necrosis_factor-alpha	15,42	interleukin-1_beta	44,62	tumor necrosis factor-alpha	interleukin-1 beta	100009088(Tax:9986)	100008990(Tax:9986)	Gene	Gene	interleukin-8|amod|START_ENTITY interleukin-8|amod|END_ENTITY	Involvement of tumor_necrosis_factor-alpha , interleukin-1_beta , interleukin-8 , and interleukin-1 receptor antagonist in acute_lung_injury caused by local Shwartzman reaction .
15716832	0	tumor_necrosis_factor-alpha	12,39	interleukin-1beta	56,73	tumor necrosis factor-alpha	interleukin-1beta	7124	3553	Gene	Gene	tumor|amod|START_ENTITY tumor|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , interleukin-6 , interleukin-1beta , soluble tumor necrosis factor receptors I and II , interleukin-6 soluble receptor , interleukin-1 soluble receptor type II , interleukin-1 receptor antagonist , and protein in the synovial fluid of patients with temporomandibular_joint_disorders .
10569139	0	tumor_necrosis_factor-alpha	24,51	interleukin-2	184,197	tumor necrosis factor-alpha	interleukin-2	7124	3558	Gene	Gene	concentrations|nmod|START_ENTITY control|nsubj|concentrations control|nmod|END_ENTITY	Blood concentrations of tumor_necrosis_factor-alpha in malignant_lymphomas and their decrease as a predictor of disease control in response to low-dose subcutaneous immunotherapy with interleukin-2 .
15806975	0	tumor_necrosis_factor-alpha	80,107	interleukin-2	121,134	tumor necrosis factor-alpha	interleukin-2	7124	3558	Gene	Gene	interferon-gamma|appos|START_ENTITY efficacy|appos|interferon-gamma END_ENTITY|nsubj|efficacy	-LSB- Clinical efficacy and T-lymphocyte subset , serum interferon-gamma -LRB- IFN-gamma -RRB- , tumor_necrosis_factor-alpha -LRB- TNF-alpha -RRB- , interleukin-2 -LRB- IL-2 -RRB- levels on treatment of chronic_aplastic_anemia patients by shenfu injection combined with stanozol and cyclosporin_A -RSB- .
19922107	0	tumor_necrosis_factor-alpha	45,72	interleukin-2	85,98	tumor necrosis factor-alpha	interleukin-2	7124	3558	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Clinical significance of measuring levels of tumor_necrosis_factor-alpha and soluble interleukin-2 receptor in nasopharyngeal_carcinoma .
2056069	0	tumor_necrosis_factor-alpha	95,122	interleukin-2	65,78	tumor necrosis factor-alpha	interleukin-2	7124	3558	Gene	Gene	levels|amod|START_ENTITY levels|dep|levels levels|compound|END_ENTITY	Serum cytokine levels in chronic_progressive_multiple_sclerosis : interleukin-2 levels parallel tumor_necrosis_factor-alpha levels .
18722671	0	tumor_necrosis_factor-alpha	10,37	interleukin-4	58,71	tumor necrosis factor-alpha	interleukin-4	7124	3565	Gene	Gene	concentrations|amod|START_ENTITY concentrations|nmod|concentrations concentrations|compound|END_ENTITY	Increased tumor_necrosis_factor-alpha concentrations with interleukin-4 concentrations in exacerbations of schizophrenia .
8413882	0	tumor_necrosis_factor-alpha	129,156	interleukin-4	85,98	tumor necrosis factor-alpha	interleukin-4	7124	3565	Gene	Gene	interferon-gamma|amod|START_ENTITY Modulation|nmod|interferon-gamma Modulation|nmod|glioblastoma glioblastoma|nmod|END_ENTITY	Modulation of proliferation and antigen expression of a cloned human glioblastoma by interleukin-4 alone and in combination with tumor_necrosis_factor-alpha and/or interferon-gamma .
10669346	0	tumor_necrosis_factor-alpha	45,72	interleukin-6	74,87	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	concentrations|dep|START_ENTITY concentrations|amod|END_ENTITY	Prognostic value of cytokine concentrations -LRB- tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-10 -RRB- and clinical parameters in severe melioidosis .
11071592	0	tumor_necrosis_factor-alpha	131,158	interleukin-6	117,130	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	response|compound|START_ENTITY response|amod|END_ENTITY	Survival of malnourished_head_and_neck_cancer patients can be predicted by human leukocyte antigen-DR expression and interleukin-6 / tumor_necrosis_factor-alpha response of the monocyte .
11549342	0	tumor_necrosis_factor-alpha	83,110	interleukin-6	18,31	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	increase|nmod|START_ENTITY Overexpression|dep|increase Overexpression|nmod|viral_myocarditis viral_myocarditis|amod|END_ENTITY	Overexpression of interleukin-6 aggravates viral_myocarditis : impaired increase in tumor_necrosis_factor-alpha .
14692886	0	tumor_necrosis_factor-alpha	27,54	interleukin-6	56,69	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	interleukin-10|compound|START_ENTITY interleukin-10|dep|END_ENTITY	Investigation of cytokine -LRB- tumor_necrosis_factor-alpha , interleukin-6 , interleukin-10 -RRB- concentrations in the cerebrospinal fluid of female patients with multiple_sclerosis and systemic_lupus_erythematosus .
15102517	0	tumor_necrosis_factor-alpha	114,141	interleukin-6	47,60	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	levels|nmod|START_ENTITY glucocorticoid|nmod|levels glucocorticoid|dobj|sensitivity sensitivity|nmod|release release|amod|END_ENTITY	Reduced glucocorticoid sensitivity of monocyte interleukin-6 release in male employees with high plasma levels of tumor_necrosis_factor-alpha .
15190958	0	tumor_necrosis_factor-alpha	153,180	interleukin-6	106,119	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Hyperglycemia at admission to the intensive care unit is associated with elevated serum concentrations of interleukin-6 and reduced ex vivo secretion of tumor_necrosis_factor-alpha .
15203561	0	tumor_necrosis_factor-alpha	16,43	interleukin-6	45,58	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	levels|nmod|START_ENTITY levels|amod|END_ENTITY	Serum levels of tumor_necrosis_factor-alpha , interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter_pylori-associated gastritis .
15716832	0	tumor_necrosis_factor-alpha	12,39	interleukin-6	41,54	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	tumor|amod|START_ENTITY tumor|amod|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , interleukin-6 , interleukin-1beta , soluble tumor necrosis factor receptors I and II , interleukin-6 soluble receptor , interleukin-1 soluble receptor type II , interleukin-1 receptor antagonist , and protein in the synovial fluid of patients with temporomandibular_joint_disorders .
16731080	0	tumor_necrosis_factor-alpha	36,63	interleukin-6	98,111	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Multilocus interactions at maternal tumor_necrosis_factor-alpha , tumor necrosis factor receptors , interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm_labor in European-American women .
1727819	0	tumor_necrosis_factor-alpha	20,47	interleukin-6	102,115	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|release release|nmod|gonadotropin gonadotropin|acl|using using|dobj|END_ENTITY	Trophoblast-derived tumor_necrosis_factor-alpha induces release of human chorionic gonadotropin using interleukin-6 -LRB- IL-6 -RRB- and IL-6-receptor-dependent system in the normal human trophoblasts .
1768380	0	tumor_necrosis_factor-alpha	77,104	interleukin-6	6,19	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	elevated|nmod|START_ENTITY elevated|nsubjpass|concentrations concentrations|amod|END_ENTITY	Serum interleukin-6 concentrations are elevated and associated with elevated tumor_necrosis_factor-alpha and immunoglobulin G and A concentrations in children with HIV_infection .
18162526	0	tumor_necrosis_factor-alpha	29,56	interleukin-6	162,175	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	increases|nsubj|START_ENTITY increases|xcomp|transporter-4 transporter-4|nmod|surface surface|nmod|cells cells|nmod|changes changes|nmod|END_ENTITY	The proinflammatory cytokine tumor_necrosis_factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6 .
18515973	0	tumor_necrosis_factor-alpha	91,118	interleukin-6	30,43	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	those|nmod|START_ENTITY distinct|nmod|those mechanisms|acl:relcl|distinct END_ENTITY|nmod|mechanisms	7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor_necrosis_factor-alpha , in vascular smooth muscle cells .
18534002	0	tumor_necrosis_factor-alpha	37,64	interleukin-6	66,79	tumor necrosis factor-alpha	interleukin-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	immunoglobulin|amod|START_ENTITY immunoglobulin|amod|END_ENTITY	Therapeutic effects of antibodies to tumor_necrosis_factor-alpha , interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate_isomerase induced arthritis .
2226778	0	tumor_necrosis_factor-alpha	76,103	interleukin-6	27,40	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|amod|END_ENTITY	Differential regulation of interleukin-6 expression in human fibroblasts by tumor_necrosis_factor-alpha and lymphotoxin .
7482719	0	tumor_necrosis_factor-alpha	31,58	interleukin-6	16,29	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	The relation of interleukin-6 , tumor_necrosis_factor-alpha , IL-2 , and IL-2_receptor levels to cellular rejection , allograft_dysfunction , and clinical events early after cardiac transplantation .
8015641	0	tumor_necrosis_factor-alpha	52,79	interleukin-6	81,94	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	secretion|amod|START_ENTITY secretion|amod|END_ENTITY	Effect of hemodialysis on peripheral blood monocyte tumor_necrosis_factor-alpha , interleukin-6 , and interleukin-8 secretion in vitro .
8649562	0	tumor_necrosis_factor-alpha	39,66	interleukin-6	81,94	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	START_ENTITY|dobj|production production|amod|END_ENTITY	Interferon-beta 1b treatment decreases tumor_necrosis_factor-alpha and increases interleukin-6 production in multiple_sclerosis .
9226842	0	tumor_necrosis_factor-alpha	23,50	interleukin-6	52,65	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	production|nmod|START_ENTITY stimulated|nmod|production stimulated|nsubj|cells cells|amod|END_ENTITY	In vitro production of tumor_necrosis_factor-alpha , interleukin-6 and interleukin-8 from normal human peripheral blood mononuclear cells stimulated by Rhodococcus_equi .
9588580	0	tumor_necrosis_factor-alpha	12,39	interleukin-6	110,123	tumor necrosis factor-alpha	interleukin-6	7124	3569	Gene	Gene	levels|amod|START_ENTITY levels|dep|relation relation|nmod|receptor receptor|amod|END_ENTITY	Circulating tumor_necrosis_factor-alpha levels in chronic_heart_failure : relation to its soluble receptor II , interleukin-6 , and neurohumoral variables .
11460304	0	tumor_necrosis_factor-alpha	11,38	interleukin-8	104,117	tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	factor|amod|START_ENTITY factor|nmod|production production|amod|END_ENTITY	Effects of tumor_necrosis_factor-alpha , epidermal growth factor and transforming growth factor-alpha on interleukin-8 production by , and human rhinovirus replication in , bronchial epithelial cells .
15302609	0	tumor_necrosis_factor-alpha	76,103	interleukin-8	61,74	tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	activity|amod|START_ENTITY activity|amod|END_ENTITY	Determination of diagnostic and prognostic values of urinary interleukin-8 , tumor_necrosis_factor-alpha , and leukocyte arylsulfatase-A activity in patients with bladder_cancer .
15845864	0	tumor_necrosis_factor-alpha	85,112	interleukin-8	39,52	tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	hyperresponsive|nmod|START_ENTITY hyperresponsive|dobj|production production|amod|END_ENTITY	Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor_necrosis_factor-alpha in structural lung cells .
1702929	0	tumor_necrosis_factor-alpha	56,83	interleukin-8	25,38	tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Cellular localization of interleukin-8 and its inducer , tumor_necrosis_factor-alpha in psoriasis .
17671691	0	tumor_necrosis_factor-alpha	39,66	interleukin-8	13,26	tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	CXCL-8|nmod|START_ENTITY CXCL-8|amod|END_ENTITY	Induction of interleukin-8 -LRB- CXCL-8 -RRB- by tumor_necrosis_factor-alpha and leukemia_inhibitory_factor in pancreatic_carcinoma cells : Impact of CXCL-8 as an autocrine growth factor .
8832978	0	tumor_necrosis_factor-alpha	21,48	interleukin-8	73,86	tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|monocyte_chemoattractant_protein-1 monocyte_chemoattractant_protein-1|amod|END_ENTITY	Antioxidants inhibit tumor_necrosis_factor-alpha mediated stimulation of interleukin-8 , monocyte_chemoattractant_protein-1 , and collagenase expression in cultured human synovial cells .
9081478	0	tumor_necrosis_factor-alpha	11,38	interleukin-8	55,68	tumor necrosis factor-alpha	interleukin-8	7124	3576	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Effect of tumor_necrosis_factor-alpha on synthesis of interleukin-8 by human monocytes and lymphocytes in vitro -RSB- .
8202660	0	tumor_necrosis_factor-alpha	36,63	interleukin_1-beta	16,34	tumor necrosis factor-alpha	interleukin 1-beta	7124	3553	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Serum levels of interleukin_1-beta , tumor_necrosis_factor-alpha , soluble interleukin 2 receptor and soluble CD8 in seronegative spondylarthropathies .
1976521	0	tumor_necrosis_factor-alpha	149,176	interleukin_1_alpha	115,134	tumor necrosis factor-alpha	interleukin 1 alpha	21926(Tax:10090)	16175(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
1976521	0	tumor_necrosis_factor-alpha	149,176	interleukin_1_alpha	27,46	tumor necrosis factor-alpha	interleukin 1 alpha	21926(Tax:10090)	16175(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY enhancement|nmod|production expression|dep|enhancement expression|nmod|END_ENTITY	Differential expression of interleukin_1_alpha by Thy-1 + and Thy-1 - lung fibroblast subpopulations : enhancement of interleukin_1_alpha production by tumor_necrosis_factor-alpha .
10526261	0	tumor_necrosis_factor-alpha	107,134	leptin	26,32	tumor necrosis factor-alpha	leptin	7124	3952	Gene	Gene	effect|nmod|START_ENTITY release|dep|effect release|nmod|END_ENTITY	Depot-specific release of leptin from subcutaneous and omental adipocytes in suspension culture : effect of tumor_necrosis_factor-alpha and transforming_growth_factor-beta1 .
11758007	0	tumor_necrosis_factor-alpha	65,92	leptin	32,38	tumor necrosis factor-alpha	leptin	7124	3952	Gene	Gene	circulating|nmod|START_ENTITY circulating|dobj|receptors receptors|amod|END_ENTITY	Association between circulating leptin and soluble receptors for tumor_necrosis_factor-alpha in hemodialysis patients .
11959686	0	tumor_necrosis_factor-alpha	60,87	leptin	50,56	tumor necrosis factor-alpha	leptin	21926(Tax:10090)	16846(Tax:10090)	Gene	Gene	inhibit|nmod|START_ENTITY inhibit|dobj|induction induction|nmod|END_ENTITY	Anti-inflammatory agents inhibit the induction of leptin by tumor_necrosis_factor-alpha .
21274300	0	tumor_necrosis_factor-alpha	44,71	leptin	73,79	tumor necrosis factor-alpha	leptin	7124	3952	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	The relationship between serum adiponectin , tumor_necrosis_factor-alpha , leptin levels and insulin sensitivity in childhood and adolescent obesity : adiponectin is a marker of metabolic_syndrome .
11371414	0	tumor_necrosis_factor-alpha	12,39	lymphotoxin-alpha	41,58	tumor necrosis factor-alpha	lymphotoxin-alpha	7124	4049	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Analysis of tumor_necrosis_factor-alpha , lymphotoxin-alpha , tumor necrosis factor receptor II , and interleukin-6 polymorphisms in patients with idiopathic pulmonary_fibrosis .
8110470	0	tumor_necrosis_factor-alpha	78,105	macrophage_inflammatory_protein-2	107,140	tumor necrosis factor-alpha	macrophage inflammatory protein-2	24835(Tax:10116)	114105(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Cytokine expression by neutrophils and macrophages in vivo : endotoxin induces tumor_necrosis_factor-alpha , macrophage_inflammatory_protein-2 , interleukin-1_beta , and interleukin-6 but not RANTES or transforming_growth_factor-beta_1 mRNA expression in acute_lung_inflammation .
16861224	0	tumor_necrosis_factor-alpha	91,118	macrophage_migration_inhibitory_factor	30,68	tumor necrosis factor-alpha	macrophage migration inhibitory factor	7124	4282	Gene	Gene	stimulation|nmod|START_ENTITY neutrophils|nmod|stimulation neutrophils|dobj|END_ENTITY	Apoptotic neutrophils release macrophage_migration_inhibitory_factor upon stimulation with tumor_necrosis_factor-alpha .
9196042	0	tumor_necrosis_factor-alpha	96,123	macrophage_migration_inhibitory_factor	18,56	tumor necrosis factor-alpha	macrophage migration inhibitory factor	24835(Tax:10116)	103694877	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of macrophage_migration_inhibitory_factor in adipose tissue and its induction by tumor_necrosis_factor-alpha .
16368650	0	tumor_necrosis_factor-alpha	29,56	matrix_metalloproteinase-12	58,85	tumor necrosis factor-alpha	matrix metalloproteinase-12	21926(Tax:10090)	17381(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	Immunohistochemical study of tumor_necrosis_factor-alpha , matrix_metalloproteinase-12 , and tissue_inhibitor_of_metalloproteinase-2 on alveolar macrophages of BALB/c mice exposed to short-term cigarette smoke .
17237282	0	tumor_necrosis_factor-alpha	88,115	mdr1	64,68	tumor necrosis factor-alpha	mdr1	7124	5243	Gene	Gene	expression|amod|START_ENTITY promoter-regulated|dobj|expression promoter-regulated|nsubj|Heat-inducible Heat-inducible|nmod|therapy therapy|nmod|colon_carcinoma colon_carcinoma|nmod|END_ENTITY	Heat-inducible in vivo gene therapy of colon_carcinoma by human mdr1 promoter-regulated tumor_necrosis_factor-alpha expression .
12399621	0	tumor_necrosis_factor-alpha	32,59	monocyte_chemoattractant_protein-1	91,125	tumor necrosis factor-alpha	monocyte chemoattractant protein-1	7124	6347	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Exogenous nitric_oxide inhibits tumor_necrosis_factor-alpha - or interleukin-1-beta-induced monocyte_chemoattractant_protein-1 expression in human mesangial cells .
12845752	0	tumor_necrosis_factor-alpha	20,47	monocyte_chemoattractant_protein-1	92,126	tumor necrosis factor-alpha	monocyte chemoattractant protein-1	280943(Tax:9913)	281043(Tax:9913)	Gene	Gene	induce|nsubj|START_ENTITY induce|dobj|expression expression|nmod|cells cells|amod|END_ENTITY	Interleukin-1_beta , tumor_necrosis_factor-alpha and lipopolysaccharide induce expression of monocyte_chemoattractant_protein-1 in calf aortic smooth muscle cells .
16436659	0	tumor_necrosis_factor-alpha	63,90	monocyte_chemoattractant_protein-1	14,48	tumor necrosis factor-alpha	monocyte chemoattractant protein-1	7124	6347	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of monocyte_chemoattractant_protein-1 expression by tumor_necrosis_factor-alpha and interleukin-1beta in first trimester human decidual cells : implications for preeclampsia .
21544387	0	tumor_necrosis_factor-alpha	59,86	monocyte_chemoattractant_protein-1	10,44	tumor necrosis factor-alpha	monocyte chemoattractant protein-1	7124	6347	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Increased monocyte_chemoattractant_protein-1 expression by tumor_necrosis_factor-alpha can mediate macrophage infiltration in gliomas .
8832978	0	tumor_necrosis_factor-alpha	21,48	monocyte_chemoattractant_protein-1	88,122	tumor necrosis factor-alpha	monocyte chemoattractant protein-1	7124	6347	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	Antioxidants inhibit tumor_necrosis_factor-alpha mediated stimulation of interleukin-8 , monocyte_chemoattractant_protein-1 , and collagenase expression in cultured human synovial cells .
15698590	0	tumor_necrosis_factor-alpha	39,66	nuclear_factor-kappaB	85,106	tumor necrosis factor-alpha	nuclear factor-kappaB	7124	4790	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Fluvastatin inhibits the expression of tumor_necrosis_factor-alpha and activation of nuclear_factor-kappaB in human endothelial cells stimulated by C-reactive_protein .
12421491	0	tumor_necrosis_factor-alpha	46,73	p27	39,42	tumor necrosis factor-alpha	p27	7124	3429	Gene	Gene	-RSB-|amod|START_ENTITY END_ENTITY|nmod|-RSB-	-LSB- The effect of cyclin kinase inhibitor p27 on tumor_necrosis_factor-alpha induced mesangial cell proliferation -RSB- .
12506117	0	tumor_necrosis_factor-alpha	73,100	p38_MAPK	130,138	tumor necrosis factor-alpha	p38 MAPK	21926(Tax:10090)	26416(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|pathway pathway|amod|END_ENTITY	Endothelial_nitric-oxide_synthase enhances lipopolysaccharide-stimulated tumor_necrosis_factor-alpha expression via cAMP-mediated p38_MAPK pathway in cardiomyocytes .
10783388	0	tumor_necrosis_factor-alpha	67,94	p38_mitogen-activated_protein_kinase	14,50	tumor necrosis factor-alpha	p38 mitogen-activated protein kinase	7124	1432	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|Activation Activation|nmod|END_ENTITY	Activation of p38_mitogen-activated_protein_kinase is required for tumor_necrosis_factor-alpha - supported proliferation of leukemia and lymphoma cell lines .
11373433	0	tumor_necrosis_factor-alpha	31,58	p38_mitogen-activated_protein_kinase	147,183	tumor necrosis factor-alpha	p38 mitogen-activated protein kinase	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	inhibitor|nmod|START_ENTITY Effects|nmod|inhibitor Effects|dep|involvement involvement|nmod|pathway pathway|amod|END_ENTITY	Effects of a dual inhibitor of tumor_necrosis_factor-alpha and interleukin-1 on lipopolysaccharide-induced lung_injury in rats : involvement of the p38_mitogen-activated_protein_kinase pathway .
16480618	0	tumor_necrosis_factor-alpha	82,109	p38_mitogen-activated_protein_kinase	24,60	tumor necrosis factor-alpha	p38 mitogen-activated protein kinase	24835(Tax:10116)	81649(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	-LSB- The modulating role of p38_mitogen-activated_protein_kinase in the expression of tumor_necrosis_factor-alpha in hepatic cells and its role in hepatic_injury in severely burned rats -RSB- .
10428056	0	tumor_necrosis_factor-alpha	17,44	p53	0,3	tumor necrosis factor-alpha	p53	7124	7157	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	p53 induction by tumor_necrosis_factor-alpha and involvement of p53 in cell death of human oligodendrocytes .
10428056	0	tumor_necrosis_factor-alpha	17,44	p53	64,67	tumor necrosis factor-alpha	p53	7124	7157	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	p53 induction by tumor_necrosis_factor-alpha and involvement of p53 in cell death of human oligodendrocytes .
11391531	0	tumor_necrosis_factor-alpha	33,60	p53	98,101	tumor necrosis factor-alpha	p53	24835(Tax:10116)	301300(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY Induction|nmod|expression independent|nsubj|Induction independent|nmod|END_ENTITY	Induction of Mdr1b expression by tumor_necrosis_factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling .
12397608	0	tumor_necrosis_factor-alpha	116,143	p53	178,181	tumor necrosis factor-alpha	p53	7124	7157	Gene	Gene	c-myc|compound|START_ENTITY c-myc|dep|END_ENTITY	Hydrostatic_pressure induces apoptosis in human chondrocytes from osteoarthritic cartilage through up-regulation of tumor_necrosis_factor-alpha , inducible_nitric_oxide_synthase , p53 , c-myc , and bax-alpha , and suppression of bcl-2 .
17283168	0	tumor_necrosis_factor-alpha	67,94	p53	0,3	tumor necrosis factor-alpha	p53	397086(Tax:9823)	7157	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|peptide peptide|compound|END_ENTITY	p53 short peptide -LRB- p53pep164 -RRB- regulates lipopolysaccharide-induced tumor_necrosis_factor-alpha factor/cytokine expression .
21541574	0	tumor_necrosis_factor-alpha	41,68	p53	13,16	tumor necrosis factor-alpha	p53	7124	7157	Gene	Gene	DNA-binding|nmod|START_ENTITY DNA-binding|nsubj|Induction Induction|nmod|END_ENTITY	Induction of p53 DNA-binding activity by tumor_necrosis_factor-alpha .
9924699	0	tumor_necrosis_factor-alpha	30,57	p53	147,150	tumor necrosis factor-alpha	p53	7124	7157	Gene	Gene	effects|nmod|START_ENTITY effects|acl|mutated mutated|dobj|END_ENTITY	Combined cytotoxic effects of tumor_necrosis_factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53 .
15249730	0	tumor_necrosis_factor-alpha	164,191	p55	192,195	tumor necrosis factor-alpha	p55	21926(Tax:10090)	21937(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|amod|END_ENTITY	Corticosterone changes in response to stressors , acute and protracted actions of tumor_necrosis_factor-alpha , and lipopolysaccharide treatments in mice lacking the tumor_necrosis_factor-alpha p55 receptor gene .
9881743	0	tumor_necrosis_factor-alpha	7,34	p55	52,55	tumor necrosis factor-alpha	p55	7124	7132	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|concentrations concentrations|amod|END_ENTITY	Plasma tumor_necrosis_factor-alpha soluble receptor p55 -LRB- sTNFp55 -RRB- concentrations in eclamptic , preeclamptic and normotensive pregnant Zimbabwean women .
15642275	0	tumor_necrosis_factor-alpha	17,44	p75	92,95	tumor necrosis factor-alpha	p75	7124	7133	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum neopterin , tumor_necrosis_factor-alpha and soluble tumor necrosis factor receptor II -LRB- p75 -RRB- levels and disease activity in Egyptian female patients with systemic_lupus_erythematosus .
12527424	0	tumor_necrosis_factor-alpha	62,89	plasminogen_activator_inhibitor-1	27,60	tumor necrosis factor-alpha	plasminogen activator inhibitor-1	21926(Tax:10090)	18787(Tax:10090)	Gene	Gene	converting|amod|START_ENTITY converting|amod|END_ENTITY	Differential expression of plasminogen_activator_inhibitor-1 , tumor_necrosis_factor-alpha , TNF-alpha converting enzyme and ADAMTS family members in murine fat territories .
23789212	0	tumor_necrosis_factor-alpha	49,76	plasminogen_activator_inhibitor-1	78,111	tumor necrosis factor-alpha	plasminogen activator inhibitor-1	7124	5054	Gene	Gene	C-reactive_protein|amod|START_ENTITY C-reactive_protein|amod|END_ENTITY	Perilla oil and exercise decrease expressions of tumor_necrosis_factor-alpha , plasminogen_activator_inhibitor-1 and highly sensitive C-reactive_protein in patients with hyperlipidemia .
10194127	0	tumor_necrosis_factor-alpha	73,100	pre-B	49,54	tumor necrosis factor-alpha	pre-B	7124	10113	Gene	Gene	cells|nmod|START_ENTITY cells|amod|END_ENTITY	Suppression of growth and dissemination in human pre-B leukemia cells by tumor_necrosis_factor-alpha in scid mice .
16439712	0	tumor_necrosis_factor-alpha	59,86	protease-activated_receptor_2	25,54	tumor necrosis factor-alpha	protease-activated receptor 2	7124	2150	Gene	Gene	START_ENTITY|nsubj|effects effects|nmod|END_ENTITY	Proangiogenic effects of protease-activated_receptor_2 are tumor_necrosis_factor-alpha and consecutively Tie2 dependent .
7835139	0	tumor_necrosis_factor-alpha	70,97	proto-oncogene_c-myc	15,35	tumor necrosis factor-alpha	proto-oncogene c-myc	7124	4609	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Inhibition of proto-oncogene_c-myc expression with recombinant human tumor_necrosis_factor-alpha and interferon-gamma in HL-60 cell lines and acute myelocytic_leukemic fresh cells -RSB- .
16116950	0	tumor_necrosis_factor-alpha	10,37	resistin	41,49	tumor necrosis factor-alpha	resistin	7124	56729	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of tumor_necrosis_factor-alpha on resistin expression in 3T3-L1 adipocytes and its mechanism .
12604697	0	tumor_necrosis_factor-alpha	66,93	semicarbazide-sensitive_amine_oxidase	14,51	tumor necrosis factor-alpha	semicarbazide-sensitive amine oxidase	21926(Tax:10090)	11754(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of semicarbazide-sensitive_amine_oxidase expression by tumor_necrosis_factor-alpha in adipocytes : functional consequences on glucose transport .
18061975	0	tumor_necrosis_factor-alpha	39,66	tenascin-C	14,24	tumor necrosis factor-alpha	tenascin-C	7124	3371	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Regulation of tenascin-C expression by tumor_necrosis_factor-alpha in cultured human osteoarthritis chondrocytes .
9594445	0	tumor_necrosis_factor-alpha	23,50	thrombomodulin	54,68	tumor necrosis factor-alpha	thrombomodulin	7124	7056	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Differential effect of tumor_necrosis_factor-alpha on thrombomodulin gene expression by human monocytoid -LRB- THP-1 -RRB- cell versus endothelial cells .
11158064	0	tumor_necrosis_factor-alpha	10,37	thyrotropin_receptor	127,147	tumor necrosis factor-alpha	thyrotropin receptor	7124	7253	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of tumor_necrosis_factor-alpha , interferon-gamma , and transforming_growth_factor-beta on adipogenesis and expression of thyrotropin_receptor in human orbital preadipocyte fibroblasts .
8077765	0	tumor_necrosis_factor-alpha	38,65	transforming_growth_factor-beta	86,117	tumor necrosis factor-alpha	transforming growth factor-beta	7124	7040	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of c-myc expression by tumor_necrosis_factor-alpha in combination with transforming_growth_factor-beta or interferon-gamma with concomitant inhibition of proliferation in human cell lines .
9736031	0	tumor_necrosis_factor-alpha	12,39	transforming_growth_factor-beta1	145,177	tumor necrosis factor-alpha	transforming growth factor-beta1	24835(Tax:10116)	59086(Tax:10116)	Gene	Gene	Transfer|nmod|START_ENTITY induces|nsubj|Transfer induces|nmod|induction induction|nmod|END_ENTITY	Transfer of tumor_necrosis_factor-alpha to rat lung induces severe pulmonary_inflammation and patchy interstitial fibrogenesis with induction of transforming_growth_factor-beta1 and myofibroblasts .
15196415	0	tumor_necrosis_factor-alpha	64,91	transforming_growth_factor-beta2	14,46	tumor necrosis factor-alpha	transforming growth factor-beta2	7124	7042	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	-LSB- Influence of transforming_growth_factor-beta2 on production of tumor_necrosis_factor-alpha and interferon-gamma from placenta of intrahepatic_cholestasis_of_pregnancy -RSB- .
14679154	0	tumor_necrosis_factor-alpha	82,109	tristetraprolin	48,63	tumor necrosis factor-alpha	tristetraprolin	7124	7538	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor_necrosis_factor-alpha expression .
14767994	0	tumor_necrosis_factor-alpha	13,40	tumor_necrosis_factor-alpha	92,119	tumor necrosis factor-alpha	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|dep|studies studies|nmod|mice mice|amod|END_ENTITY	Dual role of tumor_necrosis_factor-alpha in hepatic_ischemia-reperfusion injury : studies in tumor_necrosis_factor-alpha gene knockout mice .
14767994	0	tumor_necrosis_factor-alpha	92,119	tumor_necrosis_factor-alpha	13,40	tumor necrosis factor-alpha	tumor necrosis factor-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY studies|nmod|mice role|dep|studies role|nmod|END_ENTITY	Dual role of tumor_necrosis_factor-alpha in hepatic_ischemia-reperfusion injury : studies in tumor_necrosis_factor-alpha gene knockout mice .
24798036	0	tumor_necrosis_factor-alpha	10,37	tumor_necrosis_factor-alpha	81,108	tumor necrosis factor-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	protects|nsubj|START_ENTITY protects|nmod|END_ENTITY	Low level tumor_necrosis_factor-alpha protects cardiomyocytes against high level tumor_necrosis_factor-alpha : brief insight into a beneficial paradox .
24798036	0	tumor_necrosis_factor-alpha	81,108	tumor_necrosis_factor-alpha	10,37	tumor necrosis factor-alpha	tumor necrosis factor-alpha	7124	7124	Gene	Gene	protects|nmod|START_ENTITY protects|nsubj|END_ENTITY	Low level tumor_necrosis_factor-alpha protects cardiomyocytes against high level tumor_necrosis_factor-alpha : brief insight into a beneficial paradox .
11324713	0	tumor_necrosis_factor-alpha	70,97	tumor_necrosis_factor_receptor_type_2	13,50	tumor necrosis factor-alpha	tumor necrosis factor receptor type 2	24835(Tax:10116)	156767(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of tumor_necrosis_factor_receptor_type_2 gene expression by tumor_necrosis_factor-alpha in rat primary astrocytes .
9496711	0	tumor_necrosis_factor-alpha	81,108	tumor_necrosis_factor_receptor_type_II	23,61	tumor necrosis factor-alpha	tumor necrosis factor receptor type II	7124	7133	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Selective induction of tumor_necrosis_factor_receptor_type_II gene expression by tumor_necrosis_factor-alpha in C6 glioma cells .
22093181	0	tumor_necrosis_factor-alpha	17,44	vascular_cell_adhesion_molecule-1	70,103	tumor necrosis factor-alpha	vascular cell adhesion molecule-1	7124	7412	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Insulin augments tumor_necrosis_factor-alpha stimulated expression of vascular_cell_adhesion_molecule-1 in vascular endothelial cells .
15576639	0	tumor_necrosis_factor-alpha	136,163	vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1	48,124	tumor necrosis factor-alpha	vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1	7124	7412	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Superoxide_dismutase inhibits the expression of vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1 induced by tumor_necrosis_factor-alpha in human endothelial cells through the JNK/p38 pathways .
19553068	0	tumor_necrosis_factor-alpha	32,59	vascular_endothelial_growth_factor	82,116	tumor necrosis factor-alpha	vascular endothelial growth factor	7124	7422	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	JNK/AP -1 pathway is involved in tumor_necrosis_factor-alpha induced expression of vascular_endothelial_growth_factor in MCF7 cells .
16737974	0	tumor_necrosis_factor-alpha-converting_enzyme	78,123	TACE	125,129	tumor necrosis factor-alpha-converting enzyme	TACE	6868	6868	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	5-HT2A_receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor_necrosis_factor-alpha-converting_enzyme -LRB- TACE -RRB- activation and heparin-bound epidermal growth factor-like growth factor -LRB- HB-EGF -RRB- shedding in mesangial cells .
22631659	0	tumor_necrosis_factor-alpha-induced_protein_8	14,59	epithelial_growth_factor_receptor	105,138	tumor necrosis factor-alpha-induced protein 8	epithelial growth factor receptor	25816	1956	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|levels levels|compound|END_ENTITY	Expression of tumor_necrosis_factor-alpha-induced_protein_8 in pancreas tissues and its correlation with epithelial_growth_factor_receptor levels .
17884817	0	tumor_necrosis_factor-alpha_converting_enzyme	95,140	ADAM17	141,147	tumor necrosis factor-alpha converting enzyme	ADAM17	6868	6868	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Hypoxia-inducible factor mediates hypoxic and tumor_necrosis_factor_alpha-induced increases in tumor_necrosis_factor-alpha_converting_enzyme / ADAM17 expression by synovial cells .
12814963	0	tumor_necrosis_factor-alpha_converting_enzyme	38,83	CYP3A	0,5	tumor necrosis factor-alpha converting enzyme	CYP3A	6868	1576	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|acl|induction	CYP3A induction by N-hydroxyformamide tumor_necrosis_factor-alpha_converting_enzyme / matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans .
17822026	0	tumor_necrosis_factor-alpha_converting_enzyme	97,142	TACE	144,148	tumor necrosis factor-alpha converting enzyme	TACE	6868	6868	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Inhibition of proliferation , adhesion and invasion ability of human lung_carcinoma cell A549 by tumor_necrosis_factor-alpha_converting_enzyme -LRB- TACE -RRB- -RSB- .
17140746	0	tumor_necrosis_factor-beta	37,63	lymphotoxin-alpha	18,35	tumor necrosis factor-beta	lymphotoxin-alpha	4049	4049	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Potential role of lymphotoxin-alpha -LRB- tumor_necrosis_factor-beta -RRB- in the development of schizophrenia .
19349318	0	tumor_necrosis_factor-like_weak_inducer_of_apoptosis	17,69	TWEAK	71,76	tumor necrosis factor-like weak inducer of apoptosis	TWEAK	8742	8742	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A novel role for tumor_necrosis_factor-like_weak_inducer_of_apoptosis -LRB- TWEAK -RRB- in the development of cardiac_dysfunction and failure .
12907654	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	99,154	Apo2_ligand	87,98	tumor necrosis factor-related apoptosis-inducing ligand	Apo2 ligand	8743	8743	Gene	Gene	induction|parataxis|START_ENTITY induction|nmod|END_ENTITY	Apoptosis induction in prostate_cancer cells and xenografts by combined treatment with Apo2_ligand / tumor_necrosis_factor-related_apoptosis-inducing_ligand and CPT-11 .
12670926	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	53,108	Bax	38,41	tumor necrosis factor-related apoptosis-inducing ligand	Bax	22035(Tax:10090)	12028(Tax:10090)	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of proapoptotic molecules Bax and Bak in tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced mitochondrial disruption and apoptosis : differential regulation of cytochrome c and Smac/DIABLO release .
10506136	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	54,109	Interleukin-1	0,13	tumor necrosis factor-related apoptosis-inducing ligand	Interleukin-1	8743	3552	Gene	Gene	apoptosis|amod|START_ENTITY protects|nmod|apoptosis protects|nsubj|END_ENTITY	Interleukin-1 protects transformed keratinocytes from tumor_necrosis_factor-related_apoptosis-inducing_ligand - and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis .
17066095	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	56,111	MLL	35,38	tumor necrosis factor-related apoptosis-inducing ligand	MLL	8743	4297	Gene	Gene	rearrangement|nmod|START_ENTITY rearrangement|compound|END_ENTITY	Resistance of infant_leukemia with MLL rearrangement to tumor_necrosis_factor-related_apoptosis-inducing_ligand : a possible mechanism for poor sensitivity to antitumor immunity .
11309289	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	48,103	TRAIL	105,110	tumor necrosis factor-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Antitumor activity and bystander effects of the tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- gene .
12615731	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	94,149	TRAIL	151,156	tumor necrosis factor-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Induction of caspase_8 by interferon_gamma renders some neuroblastoma -LRB- NB -RRB- cells sensitive to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB .
15037583	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	29,84	TRAIL	86,91	tumor necrosis factor-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Uveal_melanoma expression of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptors and susceptibility to TRAIL-induced apoptosis .
16996498	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	33,88	TRAIL	90,95	tumor necrosis factor-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Generation of a novel proform of tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- protein that can be reactivated by matrix metalloproteinases .
20542572	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	45,100	TRAIL	102,107	tumor necrosis factor-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The proteasome inhibitor bortezomib disrupts tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- expression and natural killer -LRB- NK -RRB- cell killing of TRAIL receptor-positive multiple_myeloma cells .
22027835	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	86,141	TRAIL	143,148	tumor necrosis factor-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	GDP-mannose-4 ,6 - dehydratase -LRB- GMDS -RRB- deficiency renders colon_cancer cells resistant to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- receptor - and CD95-mediated apoptosis by inhibiting complex II formation .
20082449	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	65,120	XIAP-Associated_factor_1	17,41	tumor necrosis factor-related apoptosis-inducing ligand	XIAP-Associated factor 1	22035(Tax:10090)	327959(Tax:10090)	Gene	Gene	cooperates|advcl|START_ENTITY cooperates|nsubj|END_ENTITY	Tumor suppressor XIAP-Associated_factor_1 -LRB- XAF1 -RRB- cooperates with tumor_necrosis_factor-related_apoptosis-inducing_ligand to suppress colon_cancer growth and trigger tumor regression .
11245427	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	14,69	caspase-8	145,154	tumor necrosis factor-related apoptosis-inducing ligand	caspase-8	8743	841	Gene	Gene	START_ENTITY|dep|apoptosis apoptosis|nmod|expression expression|amod|END_ENTITY	Resistance to tumor_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- - induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression .
17420249	0	tumor_necrosis_factor-related_apoptosis-inducing_ligand	35,90	galectin-3	15,25	tumor necrosis factor-related apoptosis-inducing ligand	galectin-3	8743	3958	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Phosphorylated galectin-3 mediates tumor_necrosis_factor-related_apoptosis-inducing_ligand signaling by regulating phosphatase and tensin homologue deleted on chromosome 10 in human breast_carcinoma cells .
22408249	0	tumor_necrosis_factor-related_apoptosis_inducing_ligand	95,150	TRAIL	152,157	tumor necrosis factor-related apoptosis inducing ligand	TRAIL	8743	8743	Gene	Gene	signaling|amod|START_ENTITY signaling|appos|END_ENTITY	Proteasome inhibition can impair caspase-8 activation upon submaximal stimulation of apoptotic tumor_necrosis_factor-related_apoptosis_inducing_ligand -LRB- TRAIL -RRB- signaling .
24213015	0	tumor_necrosis_factor-stimulated_gene-6	14,53	TSG-6	55,60	tumor necrosis factor-stimulated gene-6	TSG-6	7130	7130	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Modulation of tumor_necrosis_factor-stimulated_gene-6 -LRB- TSG-6 -RRB- expression in human endometrium .
24732836	0	tumor_necrosis_factor_a	16,39	ADAMTS-4	62,70	tumor necrosis factor a	ADAMTS-4	7124	9507	Gene	Gene	Upregulation|nmod|START_ENTITY END_ENTITY|nsubj|Upregulation	Upregulation of tumor_necrosis_factor_a and ADAMTS-5 , but not ADAMTS-4 , in human intervertebral cartilage_endplate with modic changes .
22589541	0	tumor_necrosis_factor_a	111,134	Promyelocytic_leukemia_protein	0,30	tumor necrosis factor a	Promyelocytic leukemia protein	7124	5371	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Promyelocytic_leukemia_protein -LRB- PML -RRB- regulates endothelial cell network formation and migration in response to tumor_necrosis_factor_a -LRB- TNFa -RRB- and interferon a -LRB- IFNa -RRB- .
20801629	0	tumor_necrosis_factor_a	8,31	TNFa	33,37	tumor necrosis factor a	TNFa	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of tumor_necrosis_factor_a -LRB- TNFa -RRB- in the onset of fructose-induced nonalcoholic_fatty_liver_disease in mice .
22886597	0	tumor_necrosis_factor_a-induced_adipose-related_protein	7,62	tumor_necrosis_factor_a-induced_protein_9	64,105	tumor necrosis factor a-induced adipose-related protein	tumor necrosis factor a-induced protein 9	117167(Tax:10090)	117167(Tax:10090)	Gene	Gene	deficiency|amod|START_ENTITY deficiency|compound|END_ENTITY	Murine tumor_necrosis_factor_a-induced_adipose-related_protein -LRB- tumor_necrosis_factor_a-induced_protein_9 -RRB- deficiency leads to arthritis via interleukin-6 overproduction with enhanced NF-kB , STAT-3 signaling , and dysregulated apoptosis of macrophages .
22886597	0	tumor_necrosis_factor_a-induced_protein_9	64,105	tumor_necrosis_factor_a-induced_adipose-related_protein	7,62	tumor necrosis factor a-induced protein 9	tumor necrosis factor a-induced adipose-related protein	117167(Tax:10090)	117167(Tax:10090)	Gene	Gene	deficiency|compound|START_ENTITY deficiency|amod|END_ENTITY	Murine tumor_necrosis_factor_a-induced_adipose-related_protein -LRB- tumor_necrosis_factor_a-induced_protein_9 -RRB- deficiency leads to arthritis via interleukin-6 overproduction with enhanced NF-kB , STAT-3 signaling , and dysregulated apoptosis of macrophages .
17884764	0	tumor_necrosis_factor_alpha	49,76	AT2	9,12	tumor necrosis factor alpha	AT2	24835(Tax:10116)	24182(Tax:10116)	Gene	Gene	receptors|nmod|START_ENTITY receptors|nummod|END_ENTITY	-LSB- Role of AT2 receptors on angiotensin II-induced tumor_necrosis_factor_alpha and interleukin_1_beta secretion in adult rat cardiac fibroblasts -RSB- .
15539519	0	tumor_necrosis_factor_alpha	44,71	Bikunin	0,7	tumor necrosis factor alpha	Bikunin	7124	259	Gene	Gene	induction|compound|START_ENTITY inhibits|dobj|induction inhibits|nsubj|END_ENTITY	Bikunin inhibits lipopolysaccharide-induced tumor_necrosis_factor_alpha induction in macrophages .
11399015	0	tumor_necrosis_factor_alpha	86,113	CD4	181,184	tumor necrosis factor alpha	CD4	7124	920	Gene	Gene	START_ENTITY|nmod|predictors predictors|nmod|patients patients|nmod|T-cell T-cell|compound|END_ENTITY	Usefulness of route of transmission , absolute CD8 + T-cell counts , and levels of serum tumor_necrosis_factor_alpha as predictors of survival_of_HIV-1-infected patients with very low CD4 + T-cell counts .
17198884	0	tumor_necrosis_factor_alpha	32,59	CD4	6,9	tumor necrosis factor alpha	CD4	21926(Tax:10090)	12504(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|compound|END_ENTITY	Donor CD4 + T-cell production of tumor_necrosis_factor_alpha significantly contributes to the early proinflammatory events of graft-versus-host_disease .
18512781	0	tumor_necrosis_factor_alpha	81,108	CD4	26,29	tumor necrosis factor alpha	CD4	7124	920	Gene	Gene	discriminated|nmod|START_ENTITY discriminated|nsubjpass|activity activity|nmod|cells cells|compound|END_ENTITY	Suppressor activity among CD4 + , CD25 + + T cells is discriminated by membrane-bound tumor_necrosis_factor_alpha .
21482826	0	tumor_necrosis_factor_alpha	171,198	CD4	148,151	tumor necrosis factor alpha	CD4	7124	920	Gene	Gene	affecting|dobj|START_ENTITY expressed|xcomp|affecting expressed|nmod|cells cells|compound|END_ENTITY	HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3 , syndecan-2 , and syndecan-4 proteoglycans expressed on human activated CD4 + T cells affecting tumor_necrosis_factor_alpha and interleukin_2 production .
9616162	0	tumor_necrosis_factor_alpha	12,39	CD4	233,236	tumor necrosis factor alpha	CD4	7124	920	Gene	Gene	role|nmod|START_ENTITY function|nsubj|role function|advcl|presenting presenting|nmod|cells cells|compound|END_ENTITY	The role of tumor_necrosis_factor_alpha in modulating the quantity of peripheral blood-derived , cytokine-driven human dendritic cells and its role in enhancing the quality of dendritic cell function in presenting soluble antigens to CD4 + T cells in vitro .
12697681	0	tumor_necrosis_factor_alpha	40,67	CD40	0,4	tumor necrosis factor alpha	CD40	21926(Tax:10090)	21939(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY apoptosis|acl|induced apoptosis|compound|END_ENTITY	CD40 ligand blocks apoptosis induced by tumor_necrosis_factor_alpha , glucocorticoids , and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4 .
8666832	0	tumor_necrosis_factor_alpha	75,102	CD8	46,49	tumor necrosis factor alpha	CD8	7124	925	Gene	Gene	lymphocytes|dobj|START_ENTITY lymphocytes|nsubj|Detection Detection|nmod|T T|compound|END_ENTITY	Detection and quantification of blood-derived CD8 + T lymphocytes secreting tumor_necrosis_factor_alpha in response to HLA-A2 .1 - binding melanoma and viral peptide antigens .
10760264	0	tumor_necrosis_factor_alpha	85,112	CREB-binding_protein	29,49	tumor necrosis factor alpha	CREB-binding protein	21926(Tax:10090)	12914(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression role|nmod|END_ENTITY	A stimulus-specific role for CREB-binding_protein -LRB- CBP -RRB- in T cell receptor-activated tumor_necrosis_factor_alpha gene expression .
18039708	0	tumor_necrosis_factor_alpha	48,75	DIF2	93,97	tumor necrosis factor alpha	DIF2	7124	8870	Gene	Gene	START_ENTITY|acl|signaling signaling|nmod|promoter promoter|compound|END_ENTITY	Retinoic_acid modulates chromatin to potentiate tumor_necrosis_factor_alpha signaling on the DIF2 promoter .
8105469	0	tumor_necrosis_factor_alpha	75,102	ERBB2	28,33	tumor necrosis factor alpha	ERBB2	7124	2064	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Inverse regulation of human ERBB2 and epidermal_growth_factor_receptors by tumor_necrosis_factor_alpha .
20332214	0	tumor_necrosis_factor_alpha	96,123	Egr-1	21,26	tumor necrosis factor alpha	Egr-1	7124	1958	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	Transcription factor Egr-1 is essential for maximal matrix_metalloproteinase-9 transcription by tumor_necrosis_factor_alpha .
19760502	0	tumor_necrosis_factor_alpha	37,64	ErbB-2	19,25	tumor necrosis factor alpha	ErbB-2	7124	2064	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	Transactivation of ErbB-2 induced by tumor_necrosis_factor_alpha promotes NF-kappaB activation and breast_cancer cell proliferation .
11709312	0	tumor_necrosis_factor_alpha	132,159	IL-10	177,182	tumor necrosis factor alpha	IL-10	7124	3586	Gene	Gene	START_ENTITY|dep|-RSB- -RSB-|compound|END_ENTITY	Activation by 9 - -LRB- R -RRB- - -LSB- 2 - -LRB- phosphonomethoxy -RRB- propyl -RSB- adenine of chemokine -LRB- RANTES , macrophage_inflammatory_protein_1alpha -RRB- and cytokine -LRB- tumor_necrosis_factor_alpha , interleukin-10 -LSB- IL-10 -RSB- , IL-1beta -RRB- production .
7954438	0	tumor_necrosis_factor_alpha	165,192	IL-10	158,163	tumor necrosis factor alpha	IL-10	21926(Tax:10090)	16153(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
7954438	0	tumor_necrosis_factor_alpha	165,192	IL-4	140,144	tumor necrosis factor alpha	IL-4	21926(Tax:10090)	16189(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|compound|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
7954438	0	tumor_necrosis_factor_alpha	165,192	IL-6	146,150	tumor necrosis factor alpha	IL-6	21926(Tax:10090)	16193(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
7954438	0	tumor_necrosis_factor_alpha	165,192	IL-7	152,156	tumor necrosis factor alpha	IL-7	21926(Tax:10090)	16196(Tax:10090)	Gene	Gene	factor|dep|START_ENTITY factor|dep|END_ENTITY	Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin _ -LRB- IL -RRB- -2 , IL-4 , IL-6 , IL-7 , IL-10 , tumor_necrosis_factor_alpha , granulocyte-macrophage colony-stimulating factor , and gamma-interferon gene or admixed with conventional adjuvants .
11877397	0	tumor_necrosis_factor_alpha	40,67	IRF-7	15,20	tumor necrosis factor alpha	IRF-7	7124	3665	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Stimulation of IRF-7 gene expression by tumor_necrosis_factor_alpha : requirement for NFkappa_B transcription factor and gene accessibility .
14872485	0	tumor_necrosis_factor_alpha	33,60	Interleukin-18	0,14	tumor necrosis factor alpha	Interleukin-18	7124	3606	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Interleukin-18 enhances monocyte tumor_necrosis_factor_alpha and interleukin-1beta production induced by direct contact with T lymphocytes : implications in rheumatoid_arthritis .
15050606	0	tumor_necrosis_factor_alpha	38,65	Interleukin-1_beta	0,18	tumor necrosis factor alpha	Interleukin-1 beta	21926(Tax:10090)	16176(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1_beta -LRB- IL-1beta -RRB- induces tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation .
8630401	0	tumor_necrosis_factor_alpha	30,57	Interleukin-3	0,13	tumor necrosis factor alpha	Interleukin-3	7124	3562	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|compound|END_ENTITY	Interleukin-3 cooperates with tumor_necrosis_factor_alpha for the development of human dendritic/Langerhans cells from cord blood CD34 + hematopoietic_progenitor_cells .
23711851	0	tumor_necrosis_factor_alpha	63,90	Interleukin-33	0,14	tumor necrosis factor alpha	Interleukin-33	7124	90865	Gene	Gene	enhances|dobj|START_ENTITY enhances|nsubj|END_ENTITY	Interleukin-33 synergistically enhances immune complex-induced tumor_necrosis_factor_alpha and interleukin-8 production in cultured human synovium-derived mast cells .
8049357	0	tumor_necrosis_factor_alpha	60,87	Interleukin-8	0,13	tumor necrosis factor alpha	Interleukin-8	7124	3576	Gene	Gene	induced|nmod|START_ENTITY burst|acl|induced down-regulates|dobj|burst down-regulates|nsubj|END_ENTITY	Interleukin-8 down-regulates the oxidative burst induced by tumor_necrosis_factor_alpha in neutrophils adherent to fibronectin .
24459820	0	tumor_necrosis_factor_alpha	29,56	Interleukin_33	0,14	tumor necrosis factor alpha	Interleukin 33	21926(Tax:10090)	77125(Tax:10090)	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	Interleukin_33 is induced by tumor_necrosis_factor_alpha and interferon_gamma in keratinocytes and contributes to allergic_contact_dermatitis .
15570615	0	tumor_necrosis_factor_alpha	64,91	Matrix_metalloproteinase-2	0,26	tumor necrosis factor alpha	Matrix metalloproteinase-2	280943(Tax:9913)	282872(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Matrix_metalloproteinase-2 -LRB- MMP-2 -RRB- expression and regulation by tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- in the bovine corpus luteum .
16857167	0	tumor_necrosis_factor_alpha	42,69	Matrix_metalloproteinase-2	0,26	tumor necrosis factor alpha	Matrix metalloproteinase-2	24835(Tax:10116)	81686(Tax:10116)	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Matrix_metalloproteinase-2 contributes to tumor_necrosis_factor_alpha induced apoptosis in cultured rat cardiac myocytes .
14977922	0	tumor_necrosis_factor_alpha	28,55	MyD88	8,13	tumor necrosis factor alpha	MyD88	7124	4615	Gene	Gene	production|compound|START_ENTITY END_ENTITY|nmod|production	Role of MyD88 in diminished tumor_necrosis_factor_alpha production by newborn mononuclear cells in response to lipopolysaccharide .
7935377	0	tumor_necrosis_factor_alpha	75,102	NF-IL6	0,6	tumor necrosis factor alpha	NF-IL6	7124	1051	Gene	Gene	modulate|nmod|START_ENTITY modulate|nsubj|END_ENTITY	NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor_necrosis_factor_alpha and interleukin-1 .
11450703	0	tumor_necrosis_factor_alpha	170,197	NF-kappaB	141,150	tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	effect|compound|START_ENTITY abrogation|nmod|effect HCS-2|dep|abrogation HCS-2|dep|cells cells|nmod|END_ENTITY	Tumor_necrosis_factor_alpha induces expression of genes for matrix degradation in human chondrocyte-like HCS-2 / 8 cells through activation of NF-kappaB : abrogation of the tumor_necrosis_factor_alpha effect by proteasome inhibitors .
17481363	0	tumor_necrosis_factor_alpha	64,91	NF-kappaB	29,38	tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	cells|amod|START_ENTITY Analysis|nmod|cells Analysis|nmod|translocation translocation|amod|END_ENTITY	Analysis and quantitation of NF-kappaB nuclear translocation in tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- activated vascular endothelial cells .
19211746	0	tumor_necrosis_factor_alpha	117,144	NF-kappaB	93,102	tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	suppress|nmod|START_ENTITY suppress|dobj|activation activation|amod|END_ENTITY	Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor_necrosis_factor_alpha but is independent of its host range function .
21715489	0	tumor_necrosis_factor_alpha	95,122	NF-kappaB	0,9	tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	apoptosis|compound|START_ENTITY keratinocytes|nmod|apoptosis protects|dobj|keratinocytes protects|nsubj|END_ENTITY	NF-kappaB protects human papillomavirus type 38 E6/E7-immortalized human keratinocytes against tumor_necrosis_factor_alpha and UV-mediated apoptosis .
9653166	0	tumor_necrosis_factor_alpha	74,101	NF-kappaB	140,149	tumor necrosis factor alpha	NF-kappaB	7124	4790	Gene	Gene	production|compound|START_ENTITY dependent|nsubj|production dependent|advmod|END_ENTITY	Efficient adenoviral_infection with IkappaB_alpha reveals that macrophage tumor_necrosis_factor_alpha production in rheumatoid_arthritis is NF-kappaB dependent .
12566451	0	tumor_necrosis_factor_alpha	59,86	NF-kappa_B	9,19	tumor necrosis factor alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Impaired NF-kappa_B activation and increased production of tumor_necrosis_factor_alpha in transgenic_mice expressing keratin K10 in the basal layer of the epidermis .
12917325	0	tumor_necrosis_factor_alpha	52,79	NF-kappa_B	139,149	tumor necrosis factor alpha	NF-kappa B	7124	4790	Gene	Gene	downregulated|nmod|START_ENTITY downregulated|nmod|END_ENTITY	Expression of MIS in the testis is downregulated by tumor_necrosis_factor_alpha through the negative regulation of SF-1 transactivation by NF-kappa_B .
1653056	0	tumor_necrosis_factor_alpha	25,52	NF-kappa_B	0,10	tumor necrosis factor alpha	NF-kappa B	7124	4790	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	NF-kappa_B activation by tumor_necrosis_factor_alpha in the Jurkat T cell line is independent of protein kinase A , protein_kinase_C , and Ca -LRB- 2 + -RRB- - regulated kinases .
7624137	0	tumor_necrosis_factor_alpha	52,79	NF-kappa_B	95,105	tumor necrosis factor alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY downstream|nmod|gene located|dobj|downstream element|acl|located element|dep|pattern pattern|amod|END_ENTITY	Conserved kappa B element located downstream of the tumor_necrosis_factor_alpha gene : distinct NF-kappa_B binding pattern and enhancer activity in LPS activated murine macrophages .
7724598	0	tumor_necrosis_factor_alpha	86,113	NF-kappa_B	129,139	tumor necrosis factor alpha	NF-kappa B	21926(Tax:10090)	18033(Tax:10090)	Gene	Gene	encoding|nmod|START_ENTITY gene|acl|encoding Induction|nmod|gene mediated|nsubjpass|Induction mediated|nmod|proteins proteins|amod|END_ENTITY	Induction of the gene encoding mucosal_vascular_addressin_cell_adhesion_molecule_1 by tumor_necrosis_factor_alpha is mediated by NF-kappa_B proteins .
8816436	0	tumor_necrosis_factor_alpha	43,70	NFATp	102,107	tumor necrosis factor alpha	NFATp	7124	4773	Gene	Gene	gene|compound|START_ENTITY regulation|nmod|gene regulation|nmod|END_ENTITY	Cell-type-specific regulation of the human tumor_necrosis_factor_alpha gene in B cells and T cells by NFATp and ATF-2 / JUN. .
14673992	0	tumor_necrosis_factor_alpha	33,60	Oncostatin_M	0,12	tumor necrosis factor alpha	Oncostatin M	21926(Tax:10090)	18413(Tax:10090)	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Oncostatin_M in combination with tumor_necrosis_factor_alpha induces cartilage_damage and matrix metalloproteinase expression in vitro and in vivo .
18177935	0	tumor_necrosis_factor_alpha	117,144	Ornithine_decarboxylase	0,23	tumor necrosis factor alpha	Ornithine decarboxylase	7124	4953	Gene	Gene	interferes|nmod|START_ENTITY interferes|nsubj|END_ENTITY	Ornithine_decarboxylase interferes with macrophage-like differentiation and matrix_metalloproteinase-9 expression by tumor_necrosis_factor_alpha via NF-kappaB .
16279946	0	tumor_necrosis_factor_alpha	33,60	PAI-1	13,18	tumor necrosis factor alpha	PAI-1	7124	5054	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of PAI-1 expression by tumor_necrosis_factor_alpha in endothelial cells is mediated by its responsive element located in the 4G/5G site .
24696476	0	tumor_necrosis_factor_alpha	78,105	PD-L1	26,31	tumor necrosis factor alpha	PD-L1	7124	60533(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	HIV-1 Tat protein induces PD-L1 _ -LRB- B7-H1 -RRB- expression on dendritic cells through tumor_necrosis_factor_alpha - and toll-like_receptor_4-mediated mechanisms .
11045567	0	tumor_necrosis_factor_alpha	45,72	Peg3	19,23	tumor necrosis factor alpha	Peg3	21926(Tax:10090)	18616(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	The imprinted gene Peg3 is not essential for tumor_necrosis_factor_alpha signaling .
14585994	0	tumor_necrosis_factor_alpha	46,73	RIP1	24,28	tumor necrosis factor alpha	RIP1	21926(Tax:10090)	19766(Tax:10090)	Gene	Gene	essential|nmod|START_ENTITY essential|nsubj|END_ENTITY	The death domain kinase RIP1 is essential for tumor_necrosis_factor_alpha signaling to p38 mitogen-activated protein kinase .
11453646	0	tumor_necrosis_factor_alpha	20,47	Rac	0,3	tumor necrosis factor alpha	Rac	21926(Tax:10090)	11651(Tax:10090)	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Rac is activated by tumor_necrosis_factor_alpha and is involved in activation of Erk .
10559188	0	tumor_necrosis_factor_alpha	26,53	Sp1	2,5	tumor necrosis factor alpha	Sp1	7124	6667	Gene	Gene	functions|amod|START_ENTITY site|nmod|functions site|amod|END_ENTITY	A Sp1 binding site of the tumor_necrosis_factor_alpha promoter functions as a nitric_oxide response element .
11998373	0	tumor_necrosis_factor_alpha	74,101	THP-1	135,140	tumor necrosis factor alpha	THP-1	7124	2736	Gene	Gene	production|nmod|START_ENTITY ochratoxin_A|nmod|production influence|nmod|ochratoxin_A studies|nmod|influence studies|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- In vitro studies into the influence of ochratoxin_A on the production of tumor_necrosis_factor_alpha by the human monocytic cell line THP-1 -RSB- .
21481849	0	tumor_necrosis_factor_alpha	108,135	THP-1	149,154	tumor necrosis factor alpha	THP-1	7124	2736	Gene	Gene	START_ENTITY|nmod|cells cells|compound|END_ENTITY	aVb3-integrin expression through ERK activation mediates cell attachment and is necessary for production of tumor_necrosis_factor_alpha in monocytic THP-1 cells stimulated by phorbol_myristate_acetate .
7703311	0	tumor_necrosis_factor_alpha	37,64	THP-1	114,119	tumor necrosis factor alpha	THP-1	7124	2736	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|cells cells|compound|END_ENTITY	Estrogen modulates the expression of tumor_necrosis_factor_alpha mRNA in phorbol_ester-stimulated human monocytic THP-1 cells .
10027781	0	tumor_necrosis_factor_alpha	24,51	TNF	53,56	tumor necrosis factor alpha	TNF	7124	7124	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Polymorphism within the tumor_necrosis_factor_alpha -LRB- TNF -RRB- promoter region in patients with ankylosing_spondylitis .
18362084	0	tumor_necrosis_factor_alpha	26,53	TNF	55,58	tumor necrosis factor alpha	TNF	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interleukin-10 -LRB- IL10 -RRB- and tumor_necrosis_factor_alpha -LRB- TNF -RRB- gene polymorphisms in Parkinson 's _ disease patients .
21254282	0	tumor_necrosis_factor_alpha	17,44	TNF	46,49	tumor necrosis factor alpha	TNF	7124	7124	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Cancer risk with tumor_necrosis_factor_alpha -LRB- TNF -RRB- inhibitors : meta-analysis of randomized controlled trials of adalimumab , etanercept , and infliximab using patient level data .
11566620	0	tumor_necrosis_factor_alpha	18,45	TNF-alpha	47,56	tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Direct effects of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- on murine skeletal muscle cell lines .
11750953	0	tumor_necrosis_factor_alpha	20,47	TNF-alpha	49,58	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Predictive value of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- in preeclampsia .
12644782	0	tumor_necrosis_factor_alpha	103,130	TNF-alpha	132,141	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	Hereditary , familial , and idiopathic_chronic_pancreatitis are not associated with polymorphisms in the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- promoter region or the TNF_receptor_1 -LRB- TNFR1 -RRB- gene .
1467365	0	tumor_necrosis_factor_alpha	11,38	TNF-alpha	40,49	tumor necrosis factor alpha	TNF-alpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- on collagen_arthritis .
14767724	0	tumor_necrosis_factor_alpha	65,92	TNF-alpha	94,103	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis of the -308 G > A promoter polymorphism of the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- gene in Japanese patients with schizophrenia .
15050606	0	tumor_necrosis_factor_alpha	38,65	TNF-alpha	67,76	tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Interleukin-1_beta -LRB- IL-1beta -RRB- induces tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation .
15659876	0	tumor_necrosis_factor_alpha	18,45	TNF-alpha	47,56	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Direct effects of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- on L6 myotubes .
15865250	0	tumor_necrosis_factor_alpha	13,40	TNF-alpha	52,61	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|appos|END_ENTITY	-LSB- The role of tumor_necrosis_factor_alpha receptors -LRB- TNF-alpha -RRB- in psoriasis and other skin_disorders -RSB- .
1740661	0	tumor_necrosis_factor_alpha	21,48	TNF-alpha	50,59	tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphisms in the tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- gene correlate with murine resistance to development of toxoplasmic_encephalitis and with levels of TNF-alpha mRNA in infected brain tissue .
17481363	0	tumor_necrosis_factor_alpha	64,91	TNF-alpha	93,102	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	cells|amod|START_ENTITY cells|appos|END_ENTITY	Analysis and quantitation of NF-kappaB nuclear translocation in tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- activated vascular endothelial cells .
18560829	0	tumor_necrosis_factor_alpha	68,95	TNF-alpha	97,106	tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Establishment of a cell-based assay for examining the expression of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- gene .
20926563	0	tumor_necrosis_factor_alpha	21,48	TNF-alpha	50,59	tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Genomic profiling of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus_infection .
21502320	0	tumor_necrosis_factor_alpha	54,81	TNF-alpha	83,92	tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
2164226	0	tumor_necrosis_factor_alpha	22,49	TNF-alpha	51,60	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	inhibitor|amod|START_ENTITY inhibitor|appos|END_ENTITY	Characterization of a tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- inhibitor : evidence of immunological cross-reactivity with the TNF receptor .
2822458	0	tumor_necrosis_factor_alpha	11,38	TNF-alpha	40,49	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- to high-affinity receptors on polymorphonuclear cells .
8360023	0	tumor_necrosis_factor_alpha	26,53	TNF-alpha	55,64	tumor necrosis factor alpha	TNF-alpha	21926(Tax:10090)	21926(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The paradoxical effect of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- in endotoxin-induced uveitis .
8768061	0	tumor_necrosis_factor_alpha	17,44	TNF-alpha	46,55	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	-LSB- Significance of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- in endometriosis -RSB- .
9037662	0	tumor_necrosis_factor_alpha	15,42	TNF-alpha	44,53	tumor necrosis factor alpha	TNF-alpha	7124	7124	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	The release of tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- by interferon_gamma _ -LRB- IFN-gamma -RRB- induced THP-1 cells stimulated with smooth lipopolysaccharide is inhibited by MAbs against HLA-DR and CD14 receptors on the effector cell .
7557979	0	tumor_necrosis_factor_alpha	57,84	TNFA	86,90	tumor necrosis factor alpha	TNFA	7124	7124	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Detection of a C-insertion polymorphism within the human tumor_necrosis_factor_alpha -LRB- TNFA -RRB- gene .
9184006	0	tumor_necrosis_factor_alpha	61,88	TNFA	90,94	tumor necrosis factor alpha	TNFA	7124	7124	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	NcoI restriction fragment length polymorphism at -308 of the tumor_necrosis_factor_alpha -LRB- TNFA -RRB- promoter region in Korean .
10403560	0	tumor_necrosis_factor_alpha	15,42	TNF_alpha	44,53	tumor necrosis factor alpha	TNF alpha	7124	7124	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|appos|END_ENTITY	Correlation of tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- with high Caspase_3-like activity in myelodysplastic_syndromes .
7575990	0	tumor_necrosis_factor_alpha	44,71	TNF_alpha	73,82	tumor necrosis factor alpha	TNF alpha	7124	7124	Gene	Gene	association|amod|START_ENTITY association|appos|END_ENTITY	Effects of interferon_gamma -LRB- IFN_gamma -RRB- and tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- association in intraperitoneal radioimmunotherapy : studies on an in vitro micrometastasis model .
8832970	0	tumor_necrosis_factor_alpha	17,44	TNF_alpha	46,55	tumor necrosis factor alpha	TNF alpha	7124	7124	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Relevance of the tumor_necrosis_factor_alpha -LRB- TNF_alpha -RRB- -308 promoter polymorphism in TNF_alpha gene regulation .
8621742	0	tumor_necrosis_factor_alpha	14,41	TNFalpha	43,51	tumor necrosis factor alpha	TNFalpha	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Inhibition of tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- activity in rat brain is associated with cerebroprotection after closed_head_injury .
11494032	0	tumor_necrosis_factor_alpha	27,54	WNT10A	17,23	tumor necrosis factor alpha	WNT10A	7124	80326	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|END_ENTITY	Up-regulation of WNT10A by tumor_necrosis_factor_alpha and Helicobacter_pylori in gastric_cancer .
20236926	0	tumor_necrosis_factor_alpha	79,106	acid_sphingomyelinase	23,44	tumor necrosis factor alpha	acid sphingomyelinase	21926(Tax:10090)	20597(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Studies on the role of acid_sphingomyelinase and ceramide in the regulation of tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- - converting enzyme activity and TNFalpha secretion in macrophages .
10318823	0	tumor_necrosis_factor_alpha	19,46	activating_transcription_factor_2	61,94	tumor necrosis factor alpha	activating transcription factor 2	7124	1386	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Down-regulation of tumor_necrosis_factor_alpha expression by activating_transcription_factor_2 increases UVC-induced apoptosis of late-stage melanoma cells .
16475830	0	tumor_necrosis_factor_alpha	51,78	apolipoprotein_AI	14,31	tumor necrosis factor alpha	apolipoprotein AI	7124	335	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Inhibition of apolipoprotein_AI gene expression by tumor_necrosis_factor_alpha : roles for MEK/ERK and JNK signaling .
8054359	1	tumor_necrosis_factor_alpha	142,169	basic_fibroblast_growth_factor	220,250	tumor necrosis factor alpha	basic fibroblast growth factor	7124	2247	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation by tumor_necrosis_factor_alpha and up-regulation by transforming_growth_factor-B basic_fibroblast_growth_factor .
8065303	0	tumor_necrosis_factor_alpha	61,88	c-Myc	8,13	tumor necrosis factor alpha	c-Myc	7124	4609	Gene	Gene	cytotoxicity|nmod|START_ENTITY role|nmod|cytotoxicity plays|dobj|role plays|nsubj|END_ENTITY	Nuclear c-Myc plays an important role in the cytotoxicity of tumor_necrosis_factor_alpha in tumor cells .
2672004	0	tumor_necrosis_factor_alpha	12,39	c-abl	87,92	tumor necrosis factor alpha	c-abl	7124	25	Gene	Gene	START_ENTITY|nmod|mRNA mRNA|amod|END_ENTITY	Recombinant tumor_necrosis_factor_alpha and interleukin_1_alpha increase expression of c-abl protooncogene mRNA in cultured human marrow stromal cells .
7514454	0	tumor_necrosis_factor_alpha	70,97	c-kit	60,65	tumor necrosis factor alpha	c-kit	7124	3815	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of the density of the stem_cell_factor receptor -LRB- c-kit -RRB- by tumor_necrosis_factor_alpha on a human myeloid cell line .
3474039	0	tumor_necrosis_factor_alpha	18,45	c-myc	56,61	tumor necrosis factor alpha	c-myc	7124	4609	Gene	Gene	regulates|nsubj|START_ENTITY regulates|dobj|expression expression|amod|END_ENTITY	Recombinant human tumor_necrosis_factor_alpha regulates c-myc expression in HL-60 cells at the level of transcription .
2104745	0	tumor_necrosis_factor_alpha	26,53	cachectin	54,63	tumor necrosis factor alpha	cachectin	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	Identification|nmod|START_ENTITY Identification|dep|END_ENTITY	Identification of a novel tumor_necrosis_factor_alpha / cachectin from the livers of burned and infected rats .
8140855	0	tumor_necrosis_factor_alpha	10,37	cachectin	38,47	tumor necrosis factor alpha	cachectin	7124	7124	Gene	Gene	Levels|nmod|START_ENTITY Levels|dep|END_ENTITY	Levels of tumor_necrosis_factor_alpha / cachectin -LRB- TNF_alpha -RRB- in sera from patients with sickle_cell_disease .
11509128	0	tumor_necrosis_factor_alpha	12,39	connective_tissue_growth_factor	61,92	tumor necrosis factor alpha	connective tissue growth factor	24835(Tax:10116)	64032(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- Effects of tumor_necrosis_factor_alpha on the expression of connective_tissue_growth_factor in hepatic stellate cells -RSB- .
23929182	0	tumor_necrosis_factor_alpha	28,55	era	21,24	tumor necrosis factor alpha	era	7124	26284	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Leishmaniasis in the era of tumor_necrosis_factor_alpha antagonist therapy -- a research agenda for Europe .
14990112	0	tumor_necrosis_factor_alpha	153,180	erythropoietin	184,198	tumor necrosis factor alpha	erythropoietin	7124	2056	Gene	Gene	START_ENTITY|nmod|-RSB- -RSB-|compound|END_ENTITY	-LSB- Relationship between tumor_necrosis_factor_alpha , interleukin-6 and erythropoietin in children 's with chronic anemia and influence of recombinant human tumor_necrosis_factor_alpha on erythropoietin gene expression -RSB- .
18939362	0	tumor_necrosis_factor_alpha	98,125	insulin-like_growth_factor_1	14,42	tumor necrosis factor alpha	insulin-like growth factor 1	7124	3479	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	-LSB- Influence of insulin-like_growth_factor_1 on PECAM-1 and ICAM-1 adhesion molecules expression in tumor_necrosis_factor_alpha and hyperglycemia induced umbilical vein endothelial cells -RSB- .
7902093	0	tumor_necrosis_factor_alpha	17,44	intercellular_adhesion_molecule_1	48,81	tumor necrosis factor alpha	intercellular adhesion molecule 1	7124	3383	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	Up-regulation by tumor_necrosis_factor_alpha of intercellular_adhesion_molecule_1 expression and function in synovial fibroblasts and its inhibition by glucocorticoids .
15466213	0	tumor_necrosis_factor_alpha	86,113	interferon_gamma	17,33	tumor necrosis factor alpha	interferon gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	synergism|nmod|START_ENTITY role|nmod|synergism role|nmod|END_ENTITY	Crucial role for interferon_gamma in the synergism between tumor vasculature-targeted tumor_necrosis_factor_alpha -LRB- NGR-TNF -RRB- and doxorubicin .
9626770	0	tumor_necrosis_factor_alpha	24,51	interferon_gamma	64,80	tumor necrosis factor alpha	interferon gamma	7124	3458	Gene	Gene	production|nmod|START_ENTITY production|nmod|END_ENTITY	Increased production of tumor_necrosis_factor_alpha , and not of interferon_gamma , preceding disease activity in patients with multiple_sclerosis .
10089067	0	tumor_necrosis_factor_alpha	73,100	interleukin-6	29,42	tumor necrosis factor alpha	interleukin-6	7124	3569	Gene	Gene	infusion|nmod|START_ENTITY END_ENTITY|nmod|infusion	Transient increase of plasma interleukin-6 after infusion of recombinant tumor_necrosis_factor_alpha in advanced cancer patients .
15938966	0	tumor_necrosis_factor_alpha	20,47	interleukin-6	49,62	tumor necrosis factor alpha	interleukin-6	24835(Tax:10116)	24498(Tax:10116)	Gene	Gene	-LSB-|nmod|START_ENTITY -RSB-|advcl|-LSB- -RSB-|nsubj|levels levels|amod|END_ENTITY	-LSB- The changes in the tumor_necrosis_factor_alpha , interleukin-6 and interleukin-8 levels in the lymph and of the dynamics of the lymphokines during shock stage of rats with major burns -RSB- .
10477716	0	tumor_necrosis_factor_alpha	78,105	interleukin-8	45,58	tumor necrosis factor alpha	interleukin-8	7124	3576	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor_necrosis_factor_alpha : evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation .
12767906	0	tumor_necrosis_factor_alpha	134,161	interleukin-8	93,106	tumor necrosis factor alpha	interleukin-8	7124	3576	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Insulin-like growth factor-1 downregulates nuclear factor kappa B activation and upregulates interleukin-8 gene expression induced by tumor_necrosis_factor_alpha .
9712752	0	tumor_necrosis_factor_alpha	159,186	interleukin-8	47,60	tumor necrosis factor alpha	interleukin-8	280943(Tax:9913)	280828(Tax:9913)	Gene	Gene	due|nmod|START_ENTITY due|nsubj|pattern pattern|nmod|macrophages macrophages|amod|END_ENTITY	The biphasic mRNA expression pattern of bovine interleukin-8 in Pasteurella_haemolytica lipopolysaccharide-stimulated alveolar macrophages is primarily due to tumor_necrosis_factor_alpha .
7504295	0	tumor_necrosis_factor_alpha	84,111	interleukin_3	17,30	tumor necrosis factor alpha	interleukin 3	7124	3562	Gene	Gene	induced|nmod|START_ENTITY induced|nmod|END_ENTITY	The receptor for interleukin_3 is selectively induced in human endothelial cells by tumor_necrosis_factor_alpha and potentiates interleukin_8 secretion and neutrophil transmigration .
11058554	0	tumor_necrosis_factor_alpha	27,54	lactate_dehydrogenase_A	77,100	tumor necrosis factor alpha	lactate dehydrogenase A	7124	3939	Gene	Gene	effect|compound|START_ENTITY effect|nmod|expression expression|compound|END_ENTITY	Role of sphingosine in the tumor_necrosis_factor_alpha stimulatory effect on lactate_dehydrogenase_A expression and activity in porcine Sertoli cells .
10490793	0	tumor_necrosis_factor_alpha	11,38	leptin	42,48	tumor necrosis factor alpha	leptin	24835(Tax:10116)	25608(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|amod|END_ENTITY	Effects of tumor_necrosis_factor_alpha on leptin secretion and gene expression : relationship to changes of glucose metabolism in isolated rat adipocytes .
9529118	0	tumor_necrosis_factor_alpha	89,116	leptin	10,16	tumor necrosis factor alpha	leptin	21926(Tax:10090)	16846(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|expression expression|compound|END_ENTITY	Increased leptin expression in mice with bacterial_peritonitis is partially regulated by tumor_necrosis_factor_alpha .
7527452	0	tumor_necrosis_factor_alpha	13,40	lipoprotein_lipase	60,78	tumor necrosis factor alpha	lipoprotein lipase	21926(Tax:10090)	16956(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of tumor_necrosis_factor_alpha gene expression by lipoprotein_lipase requires protein_kinase_C activation .
8169531	0	tumor_necrosis_factor_alpha	13,40	lipoprotein_lipase	60,78	tumor necrosis factor alpha	lipoprotein lipase	21926(Tax:10090)	16956(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of tumor_necrosis_factor_alpha gene expression by lipoprotein_lipase .
20332214	0	tumor_necrosis_factor_alpha	96,123	matrix_metalloproteinase-9	52,78	tumor necrosis factor alpha	matrix metalloproteinase-9	7124	4318	Gene	Gene	essential|nmod|START_ENTITY essential|nmod|transcription transcription|amod|END_ENTITY	Transcription factor Egr-1 is essential for maximal matrix_metalloproteinase-9 transcription by tumor_necrosis_factor_alpha .
21502320	0	tumor_necrosis_factor_alpha	54,81	matrix_metalloproteinase-9	107,133	tumor necrosis factor alpha	matrix metalloproteinase-9	21926(Tax:10090)	17395(Tax:10090)	Gene	Gene	induction|amod|START_ENTITY induction|nmod|END_ENTITY	The interferon-gamma-induced GTPase , mGBP-2 , inhibits tumor_necrosis_factor_alpha -LRB- TNF-alpha -RRB- induction of matrix_metalloproteinase-9 -LRB- MMP-9 -RRB- by inhibiting NF-kappaB and Rac protein .
17975021	0	tumor_necrosis_factor_alpha	107,134	nuclear_factor-kappaB	13,34	tumor necrosis factor alpha	nuclear factor-kappaB	7124	4790	Gene	Gene	Interplay|nmod|START_ENTITY Interplay|nmod|END_ENTITY	Interplay of nuclear_factor-kappaB and B-myb in the negative regulation of androgen_receptor expression by tumor_necrosis_factor_alpha .
15087380	0	tumor_necrosis_factor_alpha	50,77	nuclear_factor_kappaB	109,130	tumor necrosis factor alpha	nuclear factor kappaB	7124	4790	Gene	Gene	stimulation|compound|START_ENTITY response|nmod|stimulation cleavage|nmod|response counteracted|nsubjpass|cleavage counteracted|nmod|END_ENTITY	Caspase-8-dependent HER-2 cleavage in response to tumor_necrosis_factor_alpha stimulation is counteracted by nuclear_factor_kappaB through c-FLIP-L expression .
17363555	0	tumor_necrosis_factor_alpha	56,83	nuclear_factor_kappaB	20,41	tumor necrosis factor alpha	nuclear factor kappaB	7124	4790	Gene	Gene	enhances|nmod|START_ENTITY enhances|dobj|activation activation|amod|END_ENTITY	Mutant p53 enhances nuclear_factor_kappaB activation by tumor_necrosis_factor_alpha in cancer cells .
10806119	0	tumor_necrosis_factor_alpha	59,86	occludin	26,34	tumor necrosis factor alpha	occludin	7124	100506658	Gene	Gene	affected|nmod|START_ENTITY affected|nsubjpass|Expression Expression|nmod|promoter promoter|compound|END_ENTITY	Expression from the human occludin promoter is affected by tumor_necrosis_factor_alpha and interferon_gamma .
17663824	0	tumor_necrosis_factor_alpha	15,42	occludin	105,113	tumor necrosis factor alpha	occludin	21926(Tax:10090)	18260(Tax:10090)	Gene	Gene	START_ENTITY|nmod|expression expression|nmod|END_ENTITY	-LSB- The impact of tumor_necrosis_factor_alpha on expression of intestinal epithelial tight junction protein occludin in fulminant_hepatic_failure mice model -RSB- .
20545441	0	tumor_necrosis_factor_alpha	34,61	p27	21,24	tumor necrosis factor alpha	p27	7124	3429	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Avian_leukosis virus p27 inhibits tumor_necrosis_factor_alpha expression in RAW264 .7 macrophages after stimulation with lipopolysaccharide .
11716533	0	tumor_necrosis_factor_alpha	15,42	p53	130,133	tumor necrosis factor alpha	p53	7124	7157	Gene	Gene	alpha|compound|START_ENTITY Combination|nmod|alpha induces|nsubj|Combination induces|nmod|pathway pathway|nmod|line line|compound|END_ENTITY	Combination of tumor_necrosis_factor_alpha and interferon alpha induces apoptotic cell death through a c-myc-dependent pathway in p53 mutant H226br non-small-cell_lung_cancer cell line .
17363555	0	tumor_necrosis_factor_alpha	56,83	p53	7,10	tumor necrosis factor alpha	p53	7124	7157	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Mutant p53 enhances nuclear_factor_kappaB activation by tumor_necrosis_factor_alpha in cancer cells .
17897950	0	tumor_necrosis_factor_alpha	115,142	p53	78,81	tumor necrosis factor alpha	p53	7124	7157	Gene	Gene	response|nmod|START_ENTITY signaling|nmod|response END_ENTITY|acl|signaling	The deubiquitinating enzyme USP11 controls an IkappaB_kinase_alpha -LRB- IKKalpha -RRB- - p53 signaling pathway in response to tumor_necrosis_factor_alpha -LRB- TNFalpha -RRB- .
15284209	0	tumor_necrosis_factor_alpha	98,125	peroxisome_proliferator-activated_receptor_gamma2	29,78	tumor necrosis factor alpha	peroxisome proliferator-activated receptor gamma2	21926(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transcription suppression of peroxisome_proliferator-activated_receptor_gamma2 gene expression by tumor_necrosis_factor_alpha via an inhibition of CCAAT / enhancer-binding protein delta during the early stage of adipocyte differentiation .
10831181	0	tumor_necrosis_factor_alpha	10,37	plasminogen_activator_inhibitor-1	79,112	tumor necrosis factor alpha	plasminogen activator inhibitor-1	7124	5054	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of tumor_necrosis_factor_alpha and transforming_growth_factor_beta_1 on plasminogen_activator_inhibitor-1 secretion from subcutaneous and omental human fat cells in suspension culture .
12212197	0	tumor_necrosis_factor_alpha	105,132	tissue_factor	80,93	tumor necrosis factor alpha	tissue factor	280943(Tax:9913)	101909187	Gene	Gene	induced|nmod|START_ENTITY END_ENTITY|acl|induced	-LSB- Effects of Buyang huanwu decoction on the release of vWF and the expression of tissue_factor induced by tumor_necrosis_factor_alpha in cultured bovine aortic endothelial cells -RSB- .
11243465	0	tumor_necrosis_factor_alpha	96,123	transforming_growth_factor_beta	14,45	tumor necrosis factor alpha	transforming growth factor beta	7124	7040	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of transforming_growth_factor_beta signaling in MCF-7 cells results in resistance to tumor_necrosis_factor_alpha : a role for Bcl-2 .
9665972	0	tumor_necrosis_factor_alpha	46,73	transforming_growth_factor_beta	102,133	tumor necrosis factor alpha	transforming growth factor beta	7124	7040	Gene	Gene	secretion|compound|START_ENTITY bovis|dobj|secretion bovis|nmod|END_ENTITY	Inhibition of Mycobacterium bovis BCG-induced tumor_necrosis_factor_alpha secretion in human cells by transforming_growth_factor_beta .
8547644	0	tumor_necrosis_factor_alpha	83,110	vascular_cell_adhesion_molecule-1	27,60	tumor necrosis factor alpha	vascular cell adhesion molecule-1	7124	7412	Gene	Gene	transcription|nmod|START_ENTITY transcription|nsubj|regulation regulation|nmod|gene gene|amod|END_ENTITY	Differential regulation of vascular_cell_adhesion_molecule-1 gene transcription by tumor_necrosis_factor_alpha and interleukin-1_alpha in dermal microvascular endothelial cells .
8910439	0	tumor_necrosis_factor_alpha	51,78	vascular_endothelial_growth_factor	13,47	tumor necrosis factor alpha	vascular endothelial growth factor	7124	7422	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by tumor_necrosis_factor_alpha in human glioma cells .
20139367	0	tumor_necrosis_factor_receptor-1	100,132	lymphotoxin_beta-receptor	133,158	tumor necrosis factor receptor-1	lymphotoxin beta-receptor	21937(Tax:10090)	17000(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY signaling|compound|END_ENTITY	Mouse aorta smooth_muscle_cells differentiate into lymphoid tissue organizer-like cells on combined tumor_necrosis_factor_receptor-1 / lymphotoxin_beta-receptor NF-kappaB signaling .
21810480	0	tumor_necrosis_factor_receptor-associated_factor_2	14,64	AWP1	0,4	tumor necrosis factor receptor-associated factor 2	AWP1	7186	54469	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	AWP1 binds to tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- and is involved in TRAF2-mediated nuclear factor-kappaB signaling .
12960157	0	tumor_necrosis_factor_receptor-associated_factor_2	42,92	CD40	0,4	tumor necrosis factor receptor-associated factor 2	CD40	7186	958	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	CD40 signaling through a newly identified tumor_necrosis_factor_receptor-associated_factor_2 -LRB- TRAF2 -RRB- binding site .
23896866	0	tumor_necrosis_factor_receptor-associated_factor_6	114,164	OX40	179,183	tumor necrosis factor receptor-associated factor 6	OX40	7189	7293	Gene	Gene	expression|amod|START_ENTITY expression|compound|END_ENTITY	Enhanced activity of Akt in Teff cells from children with lupus_nephritis is associated with reduced induction of tumor_necrosis_factor_receptor-associated_factor_6 and increased OX40 expression .
15858021	0	tumor_necrosis_factor_receptor_1	202,234	FasL	195,199	tumor necrosis factor receptor 1	FasL	21937(Tax:10090)	14103(Tax:10090)	Gene	Gene	Fas|dep|START_ENTITY Fas|dep|END_ENTITY	The Nef-mediated AIDS-like_disease of CD4C/human immunodeficiency virus transgenic_mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas - , FasL - , tumor_necrosis_factor_receptor_1 - , or interleukin-1beta-converting_enzyme-deficient or Bcl2-expressing transgenic_mice .
11110059	0	tumor_necrosis_factor_receptor_1	67,99	TNFR1	101,106	tumor necrosis factor receptor 1	TNFR1	7132	7132	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Treatment with the pure antiestrogen faslodex -LRB- ICI_182780 -RRB- induces tumor_necrosis_factor_receptor_1 -LRB- TNFR1 -RRB- expression in MCF-7 breast_cancer cells .
18641653	0	tumor_necrosis_factor_receptor_1	43,75	TRADD	16,21	tumor necrosis factor receptor 1	TRADD	21937(Tax:10090)	71609(Tax:10090)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	The function of TRADD in signaling through tumor_necrosis_factor_receptor_1 and TRIF-dependent Toll-like receptors .
18641654	0	tumor_necrosis_factor_receptor_1	21,53	TRADD	12,17	tumor necrosis factor receptor 1	TRADD	21937(Tax:10090)	71609(Tax:10090)	Gene	Gene	signaling|amod|START_ENTITY Function|nmod|signaling Function|nmod|END_ENTITY	Function of TRADD in tumor_necrosis_factor_receptor_1 signaling and in TRIF-dependent inflammatory responses .
21712071	0	tumor_necrosis_factor_receptor_1	70,102	monocyte_chemoattractant_protein-1	14,48	tumor necrosis factor receptor 1	monocyte chemoattractant protein-1	25625(Tax:10116)	24770(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of monocyte_chemoattractant_protein-1 and its induction by tumor_necrosis_factor_receptor_1 in sensory neurons in the ventral rhizotomy model of neuropathic_pain .
14644624	0	tumor_necrosis_factor_receptor_1	8,40	p55	42,45	tumor necrosis factor receptor 1	p55	21937(Tax:10090)	21937(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of tumor_necrosis_factor_receptor_1 -LRB- p55 -RRB- in hepatocyte proliferation during acetaminophen-induced toxicity in mice .
19473970	0	tumor_necrosis_factor_receptor_2	49,81	FOXO3a	0,6	tumor necrosis factor receptor 2	FOXO3a	7133	2309	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FOXO3a regulates oxygen-responsive expression of tumor_necrosis_factor_receptor_2 in human dermal microvascular endothelial cells .
24520376	0	tumor_necrosis_factor_receptor_2	49,81	Myosin_light_chain_kinase	0,25	tumor necrosis factor receptor 2	Myosin light chain kinase	7133	4638	Gene	Gene	induced|nmod|START_ENTITY expression|acl|induced expression|amod|END_ENTITY	Myosin_light_chain_kinase expression induced via tumor_necrosis_factor_receptor_2 signaling in the epithelial cells regulates the development of colitis-associated_carcinogenesis .
11144293	0	tumor_necrosis_factor_receptor_2	31,63	TNFR2	65,70	tumor necrosis factor receptor 2	TNFR2	7133	7133	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Significant association of the tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- gene with human narcolepsy .
11781288	0	tumor_necrosis_factor_receptor_2	8,40	TNFR2	42,47	tumor necrosis factor receptor 2	TNFR2	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- in colonic_epithelial_hyperplasia_and_chronic_intestinal_inflammation in mice .
12218076	0	tumor_necrosis_factor_receptor_2	12,44	TNFR2	46,51	tumor necrosis factor receptor 2	TNFR2	21938(Tax:10090)	21938(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of the tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- in cerebral_malaria in mice .
7927340	0	tumor_necrosis_factor_receptor_2	23,55	TNFR2	57,62	tumor necrosis factor receptor 2	TNFR2	7133	7133	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Linkage mapping of the tumor_necrosis_factor_receptor_2 -LRB- TNFR2 -RRB- gene to 1p36 .2 using the single-strand conformation polymorphism technique .
15603867	0	tumor_necrosis_factor_receptor_II	25,58	TNF-RII	60,67	tumor necrosis factor receptor II	TNF-RII	7133	7133	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Relationship between the tumor_necrosis_factor_receptor_II -LRB- TNF-RII -RRB- gene polymorphism and sTNF-RII plasma levels in healthy controls and in rheumatoid_arthritis .
11568974	0	tumor_necrosis_factor_receptor_superfamily_6	24,68	APT1	70,74	tumor necrosis factor receptor superfamily 6	APT1	355	355	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Hypermethylation of the tumor_necrosis_factor_receptor_superfamily_6 -LRB- APT1 , Fas , CD95/Apo -1 -RRB- gene promoter at rel/nuclear _ factor_kappaB sites in prostatic_carcinoma .
19494827	0	tumor_necrosis_factor_receptor_superfamily_member_13B	60,113	TNFRSF13B	115,124	tumor necrosis factor receptor superfamily member 13B	TNFRSF13B	23495	23495	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	An evolutionary approach to the medical implications of the tumor_necrosis_factor_receptor_superfamily_member_13B -LRB- TNFRSF13B -RRB- gene .
25915578	0	tumor_necrosis_factor_receptor_superfamily_member_8	62,113	TNFRSF8	115,122	tumor necrosis factor receptor superfamily member 8	TNFRSF8	943	943	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The potential of interleukin_12_receptor_beta_2 -LRB- IL12RB2 -RRB- and tumor_necrosis_factor_receptor_superfamily_member_8 -LRB- TNFRSF8 -RRB- gene as diagnostic biomarkers of oral_lichen_planus -LRB- OLP -RRB- .
25915578	0	tumor_necrosis_factor_receptor_superfamily_member_8	62,113	TNFRSF8	115,122	tumor necrosis factor receptor superfamily member 8	TNFRSF8	943	943	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The potential of interleukin_12_receptor_beta_2 -LRB- IL12RB2 -RRB- and tumor_necrosis_factor_receptor_superfamily_member_8 -LRB- TNFRSF8 -RRB- gene as diagnostic biomarkers of oral_lichen_planus -LRB- OLP -RRB- .
11324713	0	tumor_necrosis_factor_receptor_type_2	13,50	tumor_necrosis_factor-alpha	70,97	tumor necrosis factor receptor type 2	tumor necrosis factor-alpha	156767(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of tumor_necrosis_factor_receptor_type_2 gene expression by tumor_necrosis_factor-alpha in rat primary astrocytes .
9496711	0	tumor_necrosis_factor_receptor_type_II	23,61	tumor_necrosis_factor-alpha	81,108	tumor necrosis factor receptor type II	tumor necrosis factor-alpha	7133	7124	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Selective induction of tumor_necrosis_factor_receptor_type_II gene expression by tumor_necrosis_factor-alpha in C6 glioma cells .
21988644	0	tumor_necrosis_factor_related_apoptosis-inducing_ligand	48,103	Bcl-2	122,127	tumor necrosis factor related apoptosis-inducing ligand	Bcl-2	8743	596	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of lentivirus-mediated expression of tumor_necrosis_factor_related_apoptosis-inducing_ligand and shRNA against Bcl-2 on the growth of lymphoma cells .
24188478	0	tumor_necrosis_factor_related_apoptosis-inducing_ligand	40,95	death_receptor_5	116,132	tumor necrosis factor related apoptosis-inducing ligand	death receptor 5	8743	8795	Gene	Gene	START_ENTITY|nmod|up-regulation up-regulation|nmod|END_ENTITY	Cariporide sensitizes leukemic cells to tumor_necrosis_factor_related_apoptosis-inducing_ligand by up-regulation of death_receptor_5 via endoplasmic reticulum stress-CCAAT/enhancer _ binding_protein_homologous_protein dependent mechanism .
17349692	0	tumor_necrosis_factor_superfamily_15	31,67	TNFSF15	69,76	tumor necrosis factor superfamily 15	TNFSF15	417247(Tax:9031)	417247(Tax:9031)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Functional characterization of tumor_necrosis_factor_superfamily_15 -LRB- TNFSF15 -RRB- induced by lipopolysaccharides and Eimeria infection .
15778223	0	tumor_progression_locus_2	6,31	Tpl2	0,4	tumor progression locus 2	Tpl2	1326	1326	Gene	Gene	phosphorylation|appos|START_ENTITY phosphorylation|amod|END_ENTITY	Tpl2 -LRB- tumor_progression_locus_2 -RRB- phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B_Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals .
9053445	0	tumor_rejection_antigen	52,75	tyrosinase-related_protein_2	18,46	tumor rejection antigen	tyrosinase-related protein 2	55578	1638	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of tyrosinase-related_protein_2 as a tumor_rejection_antigen for the B16_melanoma .
12810384	0	tumor_suppressor	11,27	KAI1	33,37	tumor suppressor	KAI1	7248	3732	Gene	Gene	gene|compound|START_ENTITY Effect|nmod|gene END_ENTITY|nsubj|Effect	-LSB- Effect of tumor_suppressor gene KAI1 on the biological behaviors of human colorectal_carcinoma -RSB- .
17069699	0	tumor_suppressor	14,30	PTEN	36,40	tumor suppressor	PTEN	7248	5728	Gene	Gene	mutations|compound|START_ENTITY mutations|compound|END_ENTITY	-LSB- Mutations of tumor_suppressor gene PTEN mutations in hepatocellular_carcinoma and its implications in tumor proliferation and apoptosis -RSB- .
19281769	0	tumor_suppressor	50,66	Pten	35,39	tumor suppressor	Pten	7248	19211(Tax:10090)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Simultaneous haploinsufficiency of Pten and Trp53 tumor_suppressor genes accelerates tumorigenesis in a mouse model of prostate_cancer .
11280725	0	tumor_suppressor	30,46	RIZ1	22,26	tumor suppressor	RIZ1	7248	7799	Gene	Gene	therapy|compound|START_ENTITY END_ENTITY|nmod|therapy	Adenovirus expressing RIZ1 in tumor_suppressor gene therapy of microsatellite-unstable colorectal_cancers .
15208665	0	tumor_suppressor_candidate_1	90,118	TUSC1	125,130	tumor suppressor candidate 1	TUSC1	286319	286319	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identifying novel homozygous_deletions by microsatellite analysis and characterization of tumor_suppressor_candidate_1 gene , TUSC1 , on chromosome 9p in human lung_cancer .
15535129	0	tumor_suppressor_in_lung_cancer-1	8,41	TSLC1	43,48	tumor suppressor in lung cancer-1	TSLC1	23705	23705	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Loss of tumor_suppressor_in_lung_cancer-1 -LRB- TSLC1 -RRB- expression in meningioma correlates with increased malignancy grade and reduced patient survival .
22851235	0	tumor_suppressor_in_lung_cancer_1	19,52	TSLC1	54,59	tumor suppressor in lung cancer 1	TSLC1	23705	23705	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Down-regulation of tumor_suppressor_in_lung_cancer_1 -LRB- TSLC1 -RRB- expression correlates with poor prognosis in patients with colon_cancer .
17267202	0	tumour-associated_trypsin_inhibitor	18,53	TATI	55,59	tumour-associated trypsin inhibitor	TATI	6690	6690	Gene	Gene	Overexpression|nmod|START_ENTITY Overexpression|appos|END_ENTITY	Overexpression of tumour-associated_trypsin_inhibitor -LRB- TATI -RRB- enhances tumour growth and is associated with portal vein invasion , early recurrence and a stage-independent prognostic factor of hepatocellular_carcinoma .
11695989	0	tumour-necrosis-factor-alpha-related_apoptosis-inducing_ligand	28,90	Interleukin-10	0,14	tumour-necrosis-factor-alpha-related apoptosis-inducing ligand	Interleukin-10	22035(Tax:10090)	16153(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- gene expression in mammary epithelial cells at the involution stage .
17852877	0	tumour_necrosis_factor	41,63	B_cell-activating_factor	9,33	tumour necrosis factor	B cell-activating factor	7124	10673	Gene	Gene	family|compound|START_ENTITY END_ENTITY|nmod|family	Elevated B_cell-activating_factor of the tumour_necrosis_factor family in coeliac_disease .
10433809	0	tumour_necrosis_factor	14,36	CD120a	48,54	tumour necrosis factor	CD120a	7124	7132	Gene	Gene	receptors|compound|START_ENTITY Expression|nmod|receptors Expression|dep|END_ENTITY	Expression of tumour_necrosis_factor receptors -LRB- CD120a and CD120b -RRB- on bronchoalveolar cells .
16771860	0	tumour_necrosis_factor	26,48	CD45	0,4	tumour necrosis factor	CD45	21926(Tax:10090)	19264(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	CD45 negatively regulates tumour_necrosis_factor and interleukin-6 production in dendritic cells .
17412608	0	tumour_necrosis_factor	33,55	Interferon-gamma	0,16	tumour necrosis factor	Interferon-gamma	21926(Tax:10090)	15978(Tax:10090)	Gene	Gene	synergises|nmod|START_ENTITY synergises|nsubj|END_ENTITY	Interferon-gamma synergises with tumour_necrosis_factor and lymphotoxin-alpha to enhance the mRNA and protein expression of adhesion molecules in mouse brain endothelial cells .
8022202	0	tumour_necrosis_factor	105,127	NF-kappa_B	84,94	tumour necrosis factor	NF-kappa B	7124	4790	Gene	Gene	treatment|compound|START_ENTITY END_ENTITY|nmod|treatment	Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa_B following tumour_necrosis_factor treatment of chronic B-leukaemia cells .
22385341	0	tumour_necrosis_factor	59,81	Rv0652	27,33	tumour necrosis factor	Rv0652	21926(Tax:10090)	888078(Tax:83332)	Gene	Gene	production|nmod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Mycobacterium_tuberculosis Rv0652 stimulates production of tumour_necrosis_factor and monocytes chemoattractant protein-1 in macrophages through the Toll-like receptor 4 pathway .
7576814	0	tumour_necrosis_factor	26,48	THP-1	81,86	tumour necrosis factor	THP-1	7124	2736	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of alpha-human tumour_necrosis_factor -LRB- TNF-alpha -RRB- by human monocytes -LRB- THP-1 -RRB- exposed to 2-chloroethyl_ethyl_sulphide -LRB- H-MG -RRB- .
10369700	0	tumour_necrosis_factor	14,36	TNF	38,41	tumour necrosis factor	TNF	7124	7124	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of tumour_necrosis_factor -LRB- TNF -RRB- induced apoptosis by soluble TNF receptors in Helicobacter_pylori_infection .
10457886	0	tumour_necrosis_factor	36,58	TNF	60,63	tumour necrosis factor	TNF	7124	7124	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Analysis of the polymorphism of the tumour_necrosis_factor -LRB- TNF -RRB- gene and promoter and of circulating TNF-alpha levels in heart-transplant patients suffering or not suffering from severe rejection .
12966432	0	tumour_necrosis_factor	17,39	TNF	41,44	tumour necrosis factor	TNF	7124	7124	Gene	Gene	Polymorphisms|nmod|START_ENTITY Polymorphisms|appos|END_ENTITY	Polymorphisms in tumour_necrosis_factor -LRB- TNF -RRB- are associated with risk of bladder_cancer and grade of tumour at presentation .
24528189	0	tumour_necrosis_factor	136,158	TNF	160,163	tumour necrosis factor	TNF	7124	7124	Gene	Gene	antagonists|amod|START_ENTITY antagonists|appos|END_ENTITY	Multi-functional flow cytometry analysis of CD4 + T cells as an immune biomarker for latent_tuberculosis status in patients treated with tumour_necrosis_factor -LRB- TNF -RRB- antagonists .
7569774	0	tumour_necrosis_factor	77,99	TNF	101,104	tumour necrosis factor	TNF	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Metalloproteases and serineproteases are involved in the cleavage of the two tumour_necrosis_factor -LRB- TNF -RRB- receptors to soluble forms in the myeloid cell lines U-937 and THP-1 .
8608636	0	tumour_necrosis_factor	42,64	TNF	66,69	tumour necrosis factor	TNF	7124	7124	Gene	Gene	genes|compound|START_ENTITY genes|appos|END_ENTITY	Distribution of four polymorphisms in the tumour_necrosis_factor -LRB- TNF -RRB- genes in patients with inflammatory_bowel_disease -LRB- IBD -RRB- .
9692151	0	tumour_necrosis_factor	10,32	TNF	45,48	tumour necrosis factor	TNF	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Levels of tumour_necrosis_factor and soluble TNF receptors during malaria_fever_episodes in the community .
23056223	0	tumour_necrosis_factor	83,105	TNF-a	107,112	tumour necrosis factor	TNF-a	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Anti diabetic effect of CL 316,243 -LRB- a b3-adrenergic agonist -RRB- by down regulation of tumour_necrosis_factor -LRB- TNF-a -RRB- expression .
3426563	0	tumour_necrosis_factor	27,49	cachectin	51,60	tumour necrosis factor	cachectin	24835(Tax:10116)	24835(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of recombinant tumour_necrosis_factor -LRB- cachectin -RRB- on metabolism in isolated rat adipocyte , hepatocyte and muscle preparations .
1333789	0	tumour_necrosis_factor	21,43	interleukin-2	76,89	tumour necrosis factor	interleukin-2	7124	3558	Gene	Gene	receptors|compound|START_ENTITY Induction|nmod|receptors Induction|nmod|END_ENTITY	Induction of soluble tumour_necrosis_factor receptors during treatment with interleukin-2 .
2265482	0	tumour_necrosis_factor	66,88	interleukin-6	34,47	tumour necrosis factor	interleukin-6	7124	3569	Gene	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Dose-dependent increase in plasma interleukin-6 after recombinant tumour_necrosis_factor infusion in humans .
7772629	0	tumour_necrosis_factor	84,106	interleukin-6	108,121	tumour necrosis factor	interleukin-6	100135630(Tax:10141)	106027696	Gene	Gene	production|nmod|START_ENTITY production|amod|END_ENTITY	Effect of hepatocytes from normal or endotoxin treated animals on the production of tumour_necrosis_factor , interleukin-6 , and prostaglandin-E2 by macrophages incubated in vitro with various fatty_acids .
7833306	0	tumour_necrosis_factor	15,37	tumour_necrosis_factor	50,72	tumour necrosis factor	tumour necrosis factor	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Interleukin-6 , tumour_necrosis_factor and soluble tumour_necrosis_factor receptors in women with pre-eclampsia .
7833306	0	tumour_necrosis_factor	50,72	tumour_necrosis_factor	15,37	tumour necrosis factor	tumour necrosis factor	7124	7124	Gene	Gene	receptors|compound|START_ENTITY receptors|compound|END_ENTITY	Interleukin-6 , tumour_necrosis_factor and soluble tumour_necrosis_factor receptors in women with pre-eclampsia .
21506940	0	tumour_necrosis_factor-a	42,66	Interleukin-27	0,14	tumour necrosis factor-a	Interleukin-27	7124	246778	Gene	Gene	production|nmod|START_ENTITY enhances|dobj|production enhances|nsubj|END_ENTITY	Interleukin-27 enhances the production of tumour_necrosis_factor-a and interferon-y by bone marrow T lymphocytes in aplastic_anaemia .
21320120	0	tumour_necrosis_factor-a	57,81	Sp1	112,115	tumour necrosis factor-a	Sp1	21926(Tax:10090)	20683(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nmod|END_ENTITY	Lipopolysaccharide-induced miR-1224 negatively regulates tumour_necrosis_factor-a gene expression by modulating Sp1 .
21030411	0	tumour_necrosis_factor-a	8,32	TNFa	34,38	tumour necrosis factor-a	TNFa	280943(Tax:9913)	280943(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of tumour_necrosis_factor-a -LRB- TNFa -RRB- in the functional properties of hyalocytes .
21320120	0	tumour_necrosis_factor-a	57,81	miR-1224	27,35	tumour necrosis factor-a	miR-1224	21926(Tax:10090)	100316739(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Lipopolysaccharide-induced miR-1224 negatively regulates tumour_necrosis_factor-a gene expression by modulating Sp1 .
19656161	0	tumour_necrosis_factor-related_apoptosis-inducing_ligand	17,73	TRAIL	75,80	tumour necrosis factor-related apoptosis-inducing ligand	TRAIL	8743	8743	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Emerging role of tumour_necrosis_factor-related_apoptosis-inducing_ligand -LRB- TRAIL -RRB- as a key regulator of inflammatory responses .
21980981	0	tumour_necrosis_factor_a	19,43	prion_protein	70,83	tumour necrosis factor a	prion protein	7124	5621	Gene	Gene	apoptosis|compound|START_ENTITY apoptosis|nmod|END_ENTITY	Resistance against tumour_necrosis_factor_a apoptosis by the cellular prion_protein is cell-specific for oral , colon_and_kidney_cancer cell lines .
9300817	0	tumour_necrosis_factor_receptor-associated_factor_1	26,77	TRAF1	79,84	tumour necrosis factor receptor-associated factor 1	TRAF1	7185	7185	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Organization of the human tumour_necrosis_factor_receptor-associated_factor_1 -LRB- TRAF1 -RRB- gene and mapping to chromosome 9q33-34 .
9743209	0	tumour_necrosis_factor_receptor_2	23,56	TNF-R2	58,64	tumour necrosis factor receptor 2	TNF-R2	7133	7133	Gene	Gene	proliferation|amod|START_ENTITY proliferation|appos|END_ENTITY	Antioestrogens enhance tumour_necrosis_factor_receptor_2 -LRB- TNF-R2 -RRB- expression and TNF-R2-mediated proliferation in activated T cells .
21631498	0	tumour_necrosis_factor_receptor_type_2	46,84	CD4	99,102	tumour necrosis factor receptor type 2	CD4	7133	920	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	The phenotypic and functional consequences of tumour_necrosis_factor_receptor_type_2 expression on CD4 -LRB- + -RRB- FoxP3 -LRB- + -RRB- regulatory T cells .
12622693	0	tumour_necrosis_factor_stimulated_gene_6	8,48	TSG-6	50,55	tumour necrosis factor stimulated gene 6	TSG-6	7130	7130	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of tumour_necrosis_factor_stimulated_gene_6 -LRB- TSG-6 -RRB- in the coupling of inter-alpha-trypsin_inhibitor to hyaluronan in human follicular fluid .
17393983	0	tumour_protein_p53-induced_nuclear_protein_1	14,58	TP53INP1	60,68	tumour protein p53-induced nuclear protein 1	TP53INP1	94241	94241	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	High level of tumour_protein_p53-induced_nuclear_protein_1 -LRB- TP53INP1 -RRB- expression in anaplastic_carcinoma of the thyroid .
11597145	0	tweety	61,67	TTYH2	0,5	tweety	TTYH2	33109(Tax:7227)	94015	Gene	Gene	homologue|nmod|START_ENTITY END_ENTITY|appos|homologue	TTYH2 , a human homologue of the Drosophila_melanogaster gene tweety , is located on 17q24 and upregulated in renal_cell_carcinoma .
10198632	0	twin_of_eyeless	0,15	Pax-6	26,31	twin of eyeless	Pax-6	43833(Tax:7227)	43833(Tax:7227)	Gene	Gene	START_ENTITY|appos|gene gene|compound|END_ENTITY	twin_of_eyeless , a second Pax-6 gene of Drosophila , acts upstream of eyeless in the control of eye development .
26959880	0	twist1	96,102	p38_mitogen-activated_protein_kinase	59,95	twist1	p38 mitogen-activated protein kinase	7291	1432	Gene	Gene	pathway|amod|START_ENTITY pathway|amod|END_ENTITY	Prp19 facilitates invasion_of_hepatocellular_carcinoma via p38_mitogen-activated_protein_kinase / twist1 pathway .
21227728	0	twisted_gastrulation_homolog_1	45,75	TWSG1	77,82	twisted gastrulation homolog 1	TWSG1	57045	57045	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Minimal evidence for a direct involvement of twisted_gastrulation_homolog_1 -LRB- TWSG1 -RRB- gene in human holoprosencephaly .
7543512	0	tyk2	46,50	IL-10	0,5	tyk2	IL-10	7297	3586	Gene	Gene	phosphorylation|nmod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes .
24853614	0	type-I_procollagen	57,75	matrix_metalloproteinase-1	93,119	type-I procollagen	matrix metalloproteinase-1	1278	4312	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|nmod|END_ENTITY	CopA3 peptide prevents ultraviolet-induced inhibition of type-I_procollagen and induction of matrix_metalloproteinase-1 in human skin fibroblasts .
11416035	0	type_1_angiotensin_II_receptor	31,61	peroxisome_proliferator-activated_receptor-gamma	81,129	type 1 angiotensin II receptor	peroxisome proliferator-activated receptor-gamma	24180(Tax:10116)	25664(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Transcriptional suppression of type_1_angiotensin_II_receptor gene expression by peroxisome_proliferator-activated_receptor-gamma in vascular smooth muscle cells .
9295356	0	type_3_ryanodine_receptor	20,45	RyR3	47,51	type 3 ryanodine receptor	RyR3	100009545(Tax:9986)	100009545(Tax:9986)	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of type_3_ryanodine_receptor -LRB- RyR3 -RRB- of sarcoplasmic reticulum from rabbit skeletal muscles .
8200916	0	type_5_acid_phosphatase	24,47	Interleukin_4	0,13	type 5 acid phosphatase	Interleukin 4	11433(Tax:10090)	16189(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin_4 increases type_5_acid_phosphatase mRNA expression in murine bone marrow macrophages .
15277720	0	type_II_GnRH_receptor	6,27	GnRH	48,52	type II GnRH receptor	GnRH	114814	2796	Gene	Gene	mediates|nsubj|START_ENTITY mediates|dobj|effects effects|nmod|END_ENTITY	Human type_II_GnRH_receptor mediates effects of GnRH on cell proliferation .
27049030	0	type_II_collagen	33,49	cathepsin_K	6,17	type II collagen	cathepsin K	791241(Tax:9796)	100054991(Tax:9796)	Gene	Gene	degradation|nmod|START_ENTITY degradation|compound|END_ENTITY	Early cathepsin_K degradation of type_II_collagen in vitro and in vivo in articular cartilage .
9200478	0	type_II_phospholipase_A2	168,192	TNF-alpha	128,137	type II phospholipase A2	TNF-alpha	100135599(Tax:10141)	100135630(Tax:10141)	Gene	Gene	synthesis|amod|START_ENTITY END_ENTITY|nmod|synthesis	Endotoxin induces expression of type_II_phospholipase_A2 in macrophages during acute_lung_injury in guinea_pigs : involvement of TNF-alpha in lipopolysaccharide-induced type_II_phospholipase_A2 synthesis .
20708591	0	type_IV_collagen	18,34	BMP	44,47	type IV collagen	BMP	33727(Tax:7227)	33432(Tax:7227)	Gene	Gene	enhances|nsubj|START_ENTITY enhances|dobj|END_ENTITY	Hemocyte-secreted type_IV_collagen enhances BMP signaling to guide renal tubule morphogenesis in Drosophila .
2220807	0	type_I_procollagen	188,206	COL1A1	213,219	type I procollagen	COL1A1	1278	1277	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phenotypic heterogeneity in osteogenesis_imperfecta : the mildly affected mother of a proband with a lethal variant has the same mutation substituting cysteine for alpha 1-glycine 904 in a type_I_procollagen gene -LRB- COL1A1 -RRB- .
18434090	0	type_I_procollagen	63,81	Caveolin-1	0,10	type I procollagen	Caveolin-1	1278	857	Gene	Gene	expression|nmod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Caveolin-1 increases basal and TGF-beta1-induced expression of type_I_procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts .
18164189	0	type_I_procollagen	53,71	MMP-1	30,35	type I procollagen	MMP-1	1278	4312	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Berberine prevents UV-induced MMP-1 and reduction of type_I_procollagen expression in human dermal fibroblasts .
16447258	0	tyrosinase	37,47	ADF	19,22	tyrosinase	ADF	7299	11034	Gene	Gene	express|dobj|START_ENTITY express|nsubj|cells cells|compound|END_ENTITY	Human glioblastoma ADF cells express tyrosinase , L-tyrosine hydroxylase and melanosomes and are sensitive to L-tyrosine and phenylthiourea .
1328399	0	tyrosinase	71,81	Alpha-MSH	0,9	tyrosinase	Alpha-MSH	22173(Tax:10090)	18976(Tax:10090)	Gene	Gene	mediate|nmod|START_ENTITY mediate|nsubj|END_ENTITY	Alpha-MSH and other melanogenic activators mediate opposite effects on tyrosinase and dopachrome_tautomerase in B16/F10 mouse melanoma cells .
22895365	0	tyrosinase	32,42	Diacylglycerol_kinase	0,21	tyrosinase	Diacylglycerol kinase	7299	1607	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Diacylglycerol_kinase regulates tyrosinase expression and function in human melanocytes .
21988805	0	tyrosinase	62,72	ERK	103,106	tyrosinase	ERK	22173(Tax:10090)	26413(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38_MAPK signaling pathways .
24445257	0	tyrosinase	108,118	MITF	171,175	tyrosinase	MITF	22173(Tax:10090)	17342(Tax:10090)	Gene	Gene	expressions|amod|START_ENTITY expressions|appos|END_ENTITY	Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor -LRB- MITF -RRB- expressions and the activation of caspase-3 , _ -8 _ and _ -9 .
7969144	0	tyrosinase	113,123	Microphthalmia-associated_transcription_factor	0,46	tyrosinase	Microphthalmia-associated transcription factor	7299	4286	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Microphthalmia-associated_transcription_factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene .
11041207	0	tyrosinase	4,14	OCA1	56,60	tyrosinase	OCA1	7299	7299	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The tyrosinase gene and oculocutaneous_albinism_type_1 -LRB- OCA1 -RRB- : A model for understanding the molecular biology of melanin formation .
25761752	0	tyrosinase	38,48	SC-1	97,101	tyrosinase	SC-1	7299	6941	Gene	Gene	Cloning|nmod|START_ENTITY Cloning|nmod|END_ENTITY	Cloning and identification of a novel tyrosinase and its overexpression in Streptomyces kathirae SC-1 for enhancing melanin production .
16573534	0	tyrosinase	64,74	TYR	76,79	tyrosinase	TYR	751100(Tax:9685)	751100(Tax:9685)	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	Albinism in the domestic_cat -LRB- Felis_catus -RRB- is associated with a tyrosinase -LRB- TYR -RRB- mutation .
3009169	0	tyrosinase	92,102	alpha-MSH	15,24	tyrosinase	alpha-MSH	7299	5443	Gene	Gene	activates|dobj|START_ENTITY melanotropin|dep|activates END_ENTITY|dep|melanotropin	-LSB- Nle4 , D-Phe7 -RSB- - alpha-MSH : a superpotent melanotropin that `` irreversibly '' activates melanoma tyrosinase .
402759	0	tyrosinase	27,37	alpha-MSH	10,19	tyrosinase	alpha-MSH	22173(Tax:10090)	18976(Tax:10090)	Gene	Gene	activity|amod|START_ENTITY END_ENTITY|nmod|activity	Effect of alpha-MSH on the tyrosinase activity and the rate of melanin accumulation of melanoma cells in vitro .
8789740	0	tyrosinase	77,87	alpha-MSH	40,49	tyrosinase	alpha-MSH	7299	5443	Gene	Gene	activity|compound|START_ENTITY stimulates|dobj|activity stimulates|nsubj|peptide peptide|appos|END_ENTITY	The melanotropic peptide , -LSB- Nle4,D-Phe7 -RSB- alpha-MSH , stimulates human melanoma tyrosinase activity and inhibits cell proliferation .
8875950	0	tyrosinase	14,24	alpha-melanocyte-stimulating_hormone	57,93	tyrosinase	alpha-melanocyte-stimulating hormone	22173(Tax:10090)	18976(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY Regulation|nmod|mRNA Regulation|nmod|END_ENTITY	Regulation of tyrosinase mRNA in mouse melanoma cells by alpha-melanocyte-stimulating_hormone .
8541720	0	tyrosinase	42,52	c-Kit	31,36	tyrosinase	c-Kit	7299	3815	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Coordinated mRNA expression of c-Kit with tyrosinase and TRP-1 in melanin pigmentation of normal and malignant human melanocytes and transient activation of tyrosinase by Kit/SCF-R .
6192633	0	tyrosinase	46,56	catalase	14,22	tyrosinase	catalase	7299	847	Gene	Gene	inactivation|nmod|START_ENTITY effect|nmod|inactivation effect|nmod|END_ENTITY	The effect of catalase on the inactivation of tyrosinase by ascorbic_acid and by cysteine or glutathione .
7615964	0	tyrosinase	99,109	gp75	34,38	tyrosinase	gp75	7299	7306	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Melanocyte differentiation marker gp75 , the brown locus protein , can be regulated independently of tyrosinase and pigmentation .
26278531	0	tyrosinase	186,196	microphthalmia-associated_transcription_factor	106,152	tyrosinase	microphthalmia-associated transcription factor	22173(Tax:10090)	17342(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|glycogen_synthase_kinase_3_beta glycogen_synthase_kinase_3_beta|dep|END_ENTITY	N - -LRB- 4-bromophenethyl -RRB- _ caffeamide inhibits melanogenesis by regulating AKT / glycogen_synthase_kinase_3_beta / microphthalmia-associated_transcription_factor and tyrosinase-related_protein_1 / tyrosinase .
26278531	0	tyrosinase	186,196	microphthalmia-associated_transcription_factor	106,152	tyrosinase	microphthalmia-associated transcription factor	22173(Tax:10090)	17342(Tax:10090)	Gene	Gene	START_ENTITY|nsubj|glycogen_synthase_kinase_3_beta glycogen_synthase_kinase_3_beta|dep|END_ENTITY	N - -LRB- 4-bromophenethyl -RRB- _ caffeamide inhibits melanogenesis by regulating AKT / glycogen_synthase_kinase_3_beta / microphthalmia-associated_transcription_factor and tyrosinase-related_protein_1 / tyrosinase .
8995290	0	tyrosinase	122,132	microphthalmia-associated_transcription_factor	23,69	tyrosinase	microphthalmia-associated transcription factor	7299	4286	Gene	Gene	genes|amod|START_ENTITY transcription|nmod|genes analysis|nmod|transcription analysis|nmod|END_ENTITY	Functional analysis of microphthalmia-associated_transcription_factor in pigment cell-specific transcription of the human tyrosinase family genes .
10886507	0	tyrosinase-related_protein-2	67,95	DOPAchrome_tautomerase	96,118	tyrosinase-related protein-2	DOPAchrome tautomerase	1638	1638	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Human melanocytes and melanomas express novel mRNA isoforms of the tyrosinase-related_protein-2 / DOPAchrome_tautomerase gene : molecular and functional characterization .
12011806	0	tyrosinase-related_protein_1	29,57	TYRP1	59,64	tyrosinase-related protein 1	TYRP1	7306	7306	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA sequence variants in the tyrosinase-related_protein_1 -LRB- TYRP1 -RRB- gene are not associated with human pigmentary_glaucoma .
11004520	0	tyrosinase-related_protein_2	52,80	DOPAchrome_tautomerase	81,103	tyrosinase-related protein 2	DOPAchrome tautomerase	1638	1638	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Identification of a composite enhancer of the human tyrosinase-related_protein_2 / DOPAchrome_tautomerase gene .
11180971	0	tyrosinase-related_protein_2	14,42	DOPAchrome_tautomerase	43,65	tyrosinase-related protein 2	DOPAchrome tautomerase	1638	1638	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of tyrosinase-related_protein_2 / DOPAchrome_tautomerase in the retinoblastoma .
19953128	0	tyrosinase-related_protein_2	78,106	DOPAchrome_tautomerase	109,131	tyrosinase-related protein 2	DOPAchrome tautomerase	100170232(Tax:9940)	100170232(Tax:9940)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	Molecular cloning , sequence characteristics , and polymorphism analyses of the tyrosinase-related_protein_2 / DOPAchrome_tautomerase gene of black-boned sheep -LRB- Ovis_aries -RRB- .
10897046	0	tyrosinase-related_protein_2	72,100	TRP2	102,106	tyrosinase-related protein 2	TRP2	1638	1638	Gene	Gene	antigen|amod|START_ENTITY antigen|appos|END_ENTITY	Identification of a new HLA-A -LRB- * -RRB- 0201-restricted T-cell epitope from the tyrosinase-related_protein_2 -LRB- TRP2 -RRB- melanoma antigen .
9053445	0	tyrosinase-related_protein_2	18,46	tumor_rejection_antigen	52,75	tyrosinase-related protein 2	tumor rejection antigen	1638	55578	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of tyrosinase-related_protein_2 as a tumor_rejection_antigen for the B16_melanoma .
7860080	0	tyrosinase_related_protein-1	63,91	TYRP	93,97	tyrosinase related protein-1	TYRP	7306	7306	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Detection of a Tsp509I polymorphism in the 3 ' UTR of the human tyrosinase_related_protein-1 -LRB- TYRP -RRB- gene .
10644000	0	tyrosinase_related_protein-1	4,32	Tyrp1	34,39	tyrosinase related protein-1	Tyrp1	22178(Tax:10090)	22178(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	The tyrosinase_related_protein-1 -LRB- Tyrp1 -RRB- promoter in transgenic experiments : targeted expression to the retinal_pigment_epithelium .
21748932	0	tyrosine_hydroxylase	68,88	Alpha-synuclein	0,15	tyrosine hydroxylase	Alpha-synuclein	7054	6622	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Alpha-synuclein functions as a negative regulator for expression of tyrosine_hydroxylase .
8754788	0	tyrosine_hydroxylase	29,49	Angiotensin_II	0,14	tyrosine hydroxylase	Angiotensin II	25085(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|compound|END_ENTITY	Angiotensin_II regulation of tyrosine_hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats .
23160220	0	tyrosine_hydroxylase	10,30	CD4	49,52	tyrosine hydroxylase	CD4	21823(Tax:10090)	12504(Tax:10090)	Gene	Gene	silencing|amod|START_ENTITY silencing|nmod|T T|compound|END_ENTITY	Effect of tyrosine_hydroxylase gene silencing in CD4 + T lymphocytes on differentiation and function of helper T cells .
23940951	0	tyrosine_hydroxylase	26,46	CD4	50,53	tyrosine hydroxylase	CD4	21823(Tax:10090)	12504(Tax:10090)	Gene	Gene	START_ENTITY|nmod|T T|compound|END_ENTITY	-LSB- Changes in expression of tyrosine_hydroxylase by CD4 + T lymphocytes in lymphoid tissues of DBA/1 mice with collagen-induced_arthritis -RSB- .
24227652	0	tyrosine_hydroxylase	37,57	COUP-TFI	0,8	tyrosine hydroxylase	COUP-TFI	21823(Tax:10090)	13865(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY controls|dobj|expression controls|nsubj|END_ENTITY	COUP-TFI controls activity-dependent tyrosine_hydroxylase expression in adult dopaminergic olfactory bulb interneurons .
15447670	0	tyrosine_hydroxylase	18,38	Cdk5	72,76	tyrosine hydroxylase	Cdk5	25085(Tax:10116)	140908(Tax:10116)	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|substrate substrate|nmod|END_ENTITY	Identification of tyrosine_hydroxylase as a physiological substrate for Cdk5 .
9058055	0	tyrosine_hydroxylase	52,72	Choline_acetyltransferase	0,25	tyrosine hydroxylase	Choline acetyltransferase	25085(Tax:10116)	290567(Tax:10116)	Gene	Gene	calcitonin|amod|START_ENTITY calcitonin|amod|END_ENTITY	Choline_acetyltransferase , glutamate_decarboxylase , tyrosine_hydroxylase , calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea-pig .
11070336	0	tyrosine_hydroxylase	121,141	Corticotropin-releasing_hormone	0,31	tyrosine hydroxylase	Corticotropin-releasing hormone	25085(Tax:10116)	81648(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY decrease|nsubj|levels rise|advcl|decrease rise|nsubj|levels levels|amod|END_ENTITY	Corticotropin-releasing_hormone mRNA levels in response to chronic mild stress rise in male but not in female rats while tyrosine_hydroxylase mRNA levels decrease in both sexes .
22888292	0	tyrosine_hydroxylase	21,41	DBH	75,78	tyrosine hydroxylase	DBH	280707(Tax:9913)	280758(Tax:9913)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Genetic diversity of tyrosine_hydroxylase -LRB- TH -RRB- and dopamine_b-hydroxylase -LRB- DBH -RRB- genes in cattle breeds .
6102094	0	tyrosine_hydroxylase	32,52	Epidermal_growth_factor	0,23	tyrosine hydroxylase	Epidermal growth factor	7054	1950	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Epidermal_growth_factor induces tyrosine_hydroxylase in a clonal pheochromocytoma cell line , PC-G2 .
19285077	0	tyrosine_hydroxylase	16,36	FOXO3a	95,101	tyrosine hydroxylase	FOXO3a	7054	2309	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|nmod|END_ENTITY	SIRT1 regulates tyrosine_hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a .
20799851	0	tyrosine_hydroxylase	18,38	Fos	0,3	tyrosine hydroxylase	Fos	21823(Tax:10090)	14281(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Fos expression in tyrosine_hydroxylase containing hypothalamic neurons in CRH-KO mice : effect of immobilization stress .
8810303	0	tyrosine_hydroxylase	44,64	Inducible_cAMP_early_repressor	0,30	tyrosine hydroxylase	Inducible cAMP early repressor	25085(Tax:10116)	25620(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY modulate|dobj|expression modulate|nsubj|END_ENTITY	Inducible_cAMP_early_repressor can modulate tyrosine_hydroxylase gene expression after stimulation of cAMP synthesis .
9853519	0	tyrosine_hydroxylase	90,110	L-amino_acid_decarboxylase	124,150	tyrosine hydroxylase	L-amino acid decarboxylase	25085(Tax:10116)	24311(Tax:10116)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Behavioral recovery in 6-hydroxydopamine-lesioned rats by cotransduction of striatum with tyrosine_hydroxylase and aromatic L-amino_acid_decarboxylase genes using two separate adeno-associated virus vectors .
7909910	0	tyrosine_hydroxylase	77,97	Pituitary_adenylate_cyclase_activating_polypeptide	0,50	tyrosine hydroxylase	Pituitary adenylate cyclase activating polypeptide	280707(Tax:9913)	615187(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- potently enhances tyrosine_hydroxylase -LRB- TH -RRB- expression in adrenal chromaffin cells .
11299318	0	tyrosine_hydroxylase	22,42	Pitx3	0,5	tyrosine hydroxylase	Pitx3	21823(Tax:10090)	18742(Tax:10090)	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Pitx3 activates mouse tyrosine_hydroxylase promoter via a high-affinity binding site .
15950611	0	tyrosine_hydroxylase	16,36	Pitx3	0,5	tyrosine hydroxylase	Pitx3	21823(Tax:10090)	18742(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Pitx3 regulates tyrosine_hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development .
17184956	0	tyrosine_hydroxylase	13,33	Pitx3	73,78	tyrosine hydroxylase	Pitx3	7054	5309	Gene	Gene	expression|amod|START_ENTITY Induction|nmod|expression Induction|nmod|END_ENTITY	Induction of tyrosine_hydroxylase expression by the transcription factor Pitx3 .
10800925	0	tyrosine_hydroxylase	72,92	Ptx3	60,64	tyrosine hydroxylase	Ptx3	21823(Tax:10090)	19288(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY END_ENTITY|nmod|promoter	A response element for the homeodomain transcription factor Ptx3 in the tyrosine_hydroxylase gene promoter .
19285077	0	tyrosine_hydroxylase	16,36	SIRT1	0,5	tyrosine hydroxylase	SIRT1	7054	23411	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	SIRT1 regulates tyrosine_hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a .
15749808	0	tyrosine_hydroxylase	72,92	Smad3	112,117	tyrosine hydroxylase	Smad3	21823(Tax:10090)	17127(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Synergistic activity of activin A and basic_fibroblast_growth_factor on tyrosine_hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways .
12468040	0	tyrosine_hydroxylase	20,40	TGF-beta1	0,9	tyrosine hydroxylase	TGF-beta1	7054	7040	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	TGF-beta1 increases tyrosine_hydroxylase expression by a mechanism blocked by BMP-2 in human neuroblastoma SH-SY5Y cells .
11207940	0	tyrosine_hydroxylase	46,66	TH	68,70	tyrosine hydroxylase	TH	25085(Tax:10116)	25085(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of chronic bromocriptine treatment on tyrosine_hydroxylase -LRB- TH -RRB- mRNA expression , TH activity and median eminence dopamine concentrations in ageing rats .
11207940	0	tyrosine_hydroxylase	46,66	TH	89,91	tyrosine hydroxylase	TH	25085(Tax:10116)	25085(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of chronic bromocriptine treatment on tyrosine_hydroxylase -LRB- TH -RRB- mRNA expression , TH activity and median eminence dopamine concentrations in ageing rats .
15744773	0	tyrosine_hydroxylase	69,89	TH	91,93	tyrosine hydroxylase	TH	7054	7054	Gene	Gene	promoter|amod|START_ENTITY promoter|appos|END_ENTITY	Characterization of five evolutionary conserved regions of the human tyrosine_hydroxylase -LRB- TH -RRB- promoter : implications for the engineering of a human TH minimal promoter assembled in a self-inactivating lentiviral vector system .
16210796	0	tyrosine_hydroxylase	7,27	TH	29,31	tyrosine hydroxylase	TH	403444(Tax:9615)	403444(Tax:9615)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Canine tyrosine_hydroxylase -LRB- TH -RRB- gene and dopamine_beta _ - hydroxylase -LRB- DBH -RRB- gene : their sequences , genetic polymorphisms , and diversities among five different dog breeds .
18208403	0	tyrosine_hydroxylase	37,57	TH	59,61	tyrosine hydroxylase	TH	7054	7054	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A functional intronic variant in the tyrosine_hydroxylase -LRB- TH -RRB- gene confers risk of essential hypertension in the Northern Chinese Han population .
21310168	0	tyrosine_hydroxylase	24,44	TH	46,48	tyrosine hydroxylase	TH	7054	7054	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Effects of manganese on tyrosine_hydroxylase -LRB- TH -RRB- activity and TH-phosphorylation in a dopaminergic neural cell line .
7909910	0	tyrosine_hydroxylase	77,97	TH	99,101	tyrosine hydroxylase	TH	280707(Tax:9913)	280707(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pituitary_adenylate_cyclase_activating_polypeptide -LRB- PACAP -RRB- potently enhances tyrosine_hydroxylase -LRB- TH -RRB- expression in adrenal chromaffin cells .
15809070	0	tyrosine_hydroxylase	20,40	Urocortin_2	0,11	tyrosine hydroxylase	Urocortin 2	25085(Tax:10116)	170896(Tax:10116)	Gene	Gene	phosphorylation|amod|START_ENTITY induces|dobj|phosphorylation induces|nsubj|END_ENTITY	Urocortin_2 induces tyrosine_hydroxylase phosphorylation in PC12 cells .
17592526	0	tyrosine_hydroxylase	54,74	alpha-synuclein	10,25	tyrosine hydroxylase	alpha-synuclein	7054	6622	Gene	Gene	gene|amod|START_ENTITY Effect|nmod|gene Effect|nmod|END_ENTITY	Effect of alpha-synuclein on the promoter activity of tyrosine_hydroxylase gene .
18357527	0	tyrosine_hydroxylase	51,71	alpha-synuclein	10,25	tyrosine hydroxylase	alpha-synuclein	7054	6622	Gene	Gene	activity|amod|START_ENTITY enhances|dobj|activity enhances|csubj|Silencing Silencing|dobj|expression expression|amod|END_ENTITY	Silencing alpha-synuclein gene expression enhances tyrosine_hydroxylase activity in MN9D cells .
18406059	0	tyrosine_hydroxylase	98,118	alpha-synuclein	51,66	tyrosine hydroxylase	alpha-synuclein	7054	6622	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|increase increase|nmod|END_ENTITY	Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine_hydroxylase in SK-N-SH cells .
21656370	0	tyrosine_hydroxylase	75,95	alpha-synuclein	16,31	tyrosine hydroxylase	alpha-synuclein	7054	6622	Gene	Gene	expression|amod|START_ENTITY signaling|nmod|expression CREB|acl|signaling END_ENTITY|nmod|CREB	Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine_hydroxylase gene expression in SK-N-BE -LRB- 2 -RRB- C cells .
16356647	0	tyrosine_hydroxylase	50,70	androgen_receptor	79,96	tyrosine hydroxylase	androgen receptor	7054	367	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Regulation of the transcriptional activity of the tyrosine_hydroxylase gene by androgen_receptor .
10986016	0	tyrosine_hydroxylase	16,36	choline_acetyltransferase	59,84	tyrosine hydroxylase	choline acetyltransferase	25085(Tax:10116)	290567(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of tyrosine_hydroxylase and downregulation of choline_acetyltransferase in lead-exposed PC12 cells : the role of PKC activation .
2573410	0	tyrosine_hydroxylase	161,181	choline_acetyltransferase	110,135	tyrosine hydroxylase	choline acetyltransferase	25085(Tax:10116)	290567(Tax:10116)	Gene	Gene	activity|amod|START_ENTITY increase|nmod|activity increase|nmod|activity activity|amod|END_ENTITY	Cholinergic differentiation of clonal rat pheochromocytoma cells -LRB- PC12 -RRB- induced by retinoic_acid : increase of choline_acetyltransferase activity and decrease of tyrosine_hydroxylase activity .
8093234	0	tyrosine_hydroxylase	73,93	ciliary_neurotrophic_factor	23,50	tyrosine hydroxylase	ciliary neurotrophic factor	25085(Tax:10116)	25707(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY END_ENTITY|nmod|expression	Cooperative effects of ciliary_neurotrophic_factor and norepinephrine on tyrosine_hydroxylase expression in cultured rat locus coeruleus neurons .
1671867	0	tyrosine_hydroxylase	80,100	corticotropin-releasing_hormone	47,78	tyrosine hydroxylase	corticotropin-releasing hormone	25085(Tax:10116)	81648(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Long-term antidepressant administration alters corticotropin-releasing_hormone , tyrosine_hydroxylase , and mineralocorticoid receptor gene expression in rat brain .
9058055	0	tyrosine_hydroxylase	52,72	glutamate_decarboxylase	27,50	tyrosine hydroxylase	glutamate decarboxylase	25085(Tax:10116)	24957(Tax:10116)	Gene	Gene	calcitonin|amod|START_ENTITY calcitonin|amod|END_ENTITY	Choline_acetyltransferase , glutamate_decarboxylase , tyrosine_hydroxylase , calcitonin gene-related peptide and opioid peptides coexist in lateral efferent neurons of rat and guinea-pig .
16764822	0	tyrosine_hydroxylase	20,40	neuron-restrictive_silencer_factor	49,83	tyrosine hydroxylase	neuron-restrictive silencer factor	7054	5978	Gene	Gene	gene|compound|START_ENTITY Regulation|nmod|gene Regulation|nmod|END_ENTITY	Regulation of human tyrosine_hydroxylase gene by neuron-restrictive_silencer_factor .
7909929	0	tyrosine_hydroxylase	70,90	neuropeptide_Y	21,35	tyrosine hydroxylase	neuropeptide Y	25085(Tax:10116)	24604(Tax:10116)	Gene	Gene	activity|nmod|START_ENTITY effect|nmod|activity effect|nmod|END_ENTITY	Inhibitory effect of neuropeptide_Y -LRB- NPY -RRB- on the in vitro activity of tyrosine_hydroxylase .
11769329	0	tyrosine_hydroxylase	34,54	neurotensin	63,74	tyrosine hydroxylase	neurotensin	7054	4922	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	Transcriptional regulation of the tyrosine_hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells .
16805833	0	tyrosine_hydroxylase	14,34	retinoic_acid_receptor	54,76	tyrosine hydroxylase	retinoic acid receptor	7054	5914	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of tyrosine_hydroxylase gene expression by retinoic_acid_receptor .
25656651	0	tyrosine_kinase	8,23	Bcr-Abl	0,7	tyrosine kinase	Bcr-Abl	7294	25	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	Bcr-Abl tyrosine_kinase inhibitors : a patent review .
17148773	0	tyrosine_kinase	64,79	EGFR	59,63	tyrosine kinase	EGFR	7294	1956	Gene	Gene	inhibitors|compound|START_ENTITY inhibitors|amod|END_ENTITY	CYP3A phenotyping approach to predict systemic exposure to EGFR tyrosine_kinase inhibitors .
19716804	0	tyrosine_kinase	24,39	EGFR	19,23	tyrosine kinase	EGFR	7294	1956	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|compound|END_ENTITY	Erkitinib , a novel EGFR tyrosine_kinase inhibitor screened using a ProteoChip system from a phytochemical library .
18337055	0	tyrosine_kinase	61,76	Fyn	57,60	tyrosine kinase	Fyn	7294	2534	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Inhibition of DNA methyltransferase activity upregulates Fyn tyrosine_kinase expression in Hut-78 T-lymphoma cells .
12412144	0	tyrosine_kinase	33,48	TrkA	50,54	tyrosine kinase	TrkA	59109(Tax:10116)	59109(Tax:10116)	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|appos|END_ENTITY	Cystitis-induced upregulation of tyrosine_kinase -LRB- TrkA , TrkB -RRB- receptor expression and phosphorylation in rat micturition pathways .
9733596	0	tyrosine_kinase	63,78	focal_adhesion_kinase	96,117	tyrosine kinase	focal adhesion kinase	7294	5747	Gene	Gene	signals|amod|START_ENTITY signals|compound|END_ENTITY	Human Caco-2 intestinal epithelial motility is associated with tyrosine_kinase and cytoskeletal focal_adhesion_kinase signals .
26623053	0	tyrosine_kinase	65,80	insulin-like_growth_factor_1_receptor	27,64	tyrosine kinase	insulin-like growth factor 1 receptor	7294	3480	Gene	Gene	domain|compound|START_ENTITY domain|amod|END_ENTITY	Mutational analysis of the insulin-like_growth_factor_1_receptor tyrosine_kinase domain in non-small_cell_lung_cancer patients .
19440814	0	tyrosine_kinase_2	28,45	TYK2	47,51	tyrosine kinase 2	TYK2	7297	7297	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Lack of association between tyrosine_kinase_2 -LRB- TYK2 -RRB- gene polymorphisms and susceptibility to SLE in a Japanese population .
21239439	0	tyrosine_kinase_B	34,51	Brain-derived_neurotrophic_factor	0,33	tyrosine kinase B	Brain-derived neurotrophic factor	4915	627	Gene	Gene	signaling|compound|START_ENTITY regulates|nsubj|signaling END_ENTITY|appos|regulates	Brain-derived_neurotrophic_factor / tyrosine_kinase_B signaling regulates human trophoblast growth in an in vivo animal model of ectopic pregnancy .
11532338	0	tyrosine_kinase_B	59,76	brain_derived_neurotrophic_factor	116,149	tyrosine kinase B	brain derived neurotrophic factor	25054(Tax:10116)	24225(Tax:10116)	Gene	Gene	START_ENTITY|appos|receptor receptor|nmod|END_ENTITY	Serotonergic cells of the rat raphe nuclei express mRNA of tyrosine_kinase_B -LRB- trkB -RRB- , the high-affinity receptor for brain_derived_neurotrophic_factor -LRB- BDNF -RRB- .
23022575	0	tyrosine_kinase_receptor	15,39	Trk	41,44	tyrosine kinase receptor	Trk	4914	4914	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Alterations in tyrosine_kinase_receptor -LRB- Trk -RRB- expression induced by insulin-like_growth_factor-1 in cultured dorsal root ganglion neurons .
23769847	0	tyrosine_kinase_receptor	67,91	Trk	93,96	tyrosine kinase receptor	Trk	4914	4914	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Neuroprotective effect of insulin-like_growth_factor-1 : effects on tyrosine_kinase_receptor -LRB- Trk -RRB- expression in dorsal root ganglion neurons with glutamate-induced excitotoxicity in vitro .
12397596	0	tyrosine_phosphatase	34,54	OST-PTP	61,68	tyrosine phosphatase	OST-PTP	13924(Tax:10090)	13924(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcriptional activation of the tyrosine_phosphatase gene , OST-PTP , during osteoblast differentiation .
22678720	0	tyrosine_protein_kinase_B	70,95	TrkB	97,101	tyrosine protein kinase B	TrkB	25054(Tax:10116)	25054(Tax:10116)	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Postnatal development of brain-derived_neurotrophic_factor -LRB- BDNF -RRB- and tyrosine_protein_kinase_B -LRB- TrkB -RRB- receptor immunoreactivity in multiple brain stem respiratory-related nuclei of the rat .
24355542	0	tyrosyl-DNA-phosphodiesterase_1	39,70	TDP1	72,76	tyrosyl-DNA-phosphodiesterase 1	TDP1	55775	55775	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|appos|END_ENTITY	Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase_1 -LRB- TDP1 -RRB- in human lung_cancer cells from the NCI-60 panel .
21041670	0	tyrosyl-DNA_phosphodiesterase	8,37	TDP1	39,43	tyrosyl-DNA phosphodiesterase	TDP1	55775	55775	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of tyrosyl-DNA_phosphodiesterase -LRB- TDP1 -RRB- in mitochondria .
17576665	0	tyrosyl-DNA_phosphodiesterase	80,109	Tdp1	111,115	tyrosyl-DNA phosphodiesterase	Tdp1	55775	55775	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA_phosphodiesterase -LRB- Tdp1 -RRB- inhibitors and characterization of furamidine -LRB- NSC_305831 -RRB- as an inhibitor of Tdp1 .
24637157	0	tyrosyl-DNA_phosphodiesterase_1	85,116	TDP1	118,122	tyrosyl-DNA phosphodiesterase 1	TDP1	55775	55775	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA_phosphodiesterase_1 -LRB- TDP1 -RRB- inhibitors .
15333041	0	u-PA	72,76	FGF-2	31,36	u-PA	FGF-2	5328	2247	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA , u-PAR , and PAI-1 in endothelial cells .
21965736	0	u-PA	29,33	Oncostatin_M	0,12	u-PA	Oncostatin M	5328	5008	Gene	Gene	induce|dobj|START_ENTITY induce|nsubj|END_ENTITY	Oncostatin_M and IL-6 induce u-PA and VEGF in prostate_cancer cells and correlate in vivo .
9674732	0	u-PA	58,62	Plasminogen	0,11	u-PA	Plasminogen	5328	5340	Gene	Gene	activator|dep|START_ENTITY activator|compound|END_ENTITY	Plasminogen activator in acute myeloid leukaemic marrows : u-PA in contrast to t-PA in normal marrow .
9718068	0	u-PA	139,143	plasminogen_activator_inhibitor-1	93,126	u-PA	plasminogen activator inhibitor-1	5328	5054	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Synoviocytes from osteoarthritis and rheumatoid_arthritis produce plasminogen activators and plasminogen_activator_inhibitor-1 and display u-PA receptors on their surface .
2493685	0	u-PA	23,27	t-PA	29,33	u-PA	t-PA	5328	5327	Gene	Gene	START_ENTITY|appos|concentrations concentrations|compound|END_ENTITY	Placental and decidual u-PA , t-PA , PAI-1 and PAI-2 concentrations , as affected by cervical dilatation with laminaria tents or Hegar dilators .
3132969	0	u-PA	90,94	t-PA	69,73	u-PA	t-PA	5328	5327	Gene	Gene	tissue-type_plasminogen_activator|appos|START_ENTITY tissue-type_plasminogen_activator|appos|END_ENTITY	Artificial exon shuffling between tissue-type_plasminogen_activator -LRB- t-PA -RRB- and urokinase -LRB- u-PA -RRB- : a comparative study on the fibrinolytic properties of t-PA/u-PA hybrid proteins .
9674732	0	u-PA	58,62	t-PA	78,82	u-PA	t-PA	5328	5327	Gene	Gene	START_ENTITY|nmod|contrast contrast|nmod|END_ENTITY	Plasminogen activator in acute myeloid leukaemic marrows : u-PA in contrast to t-PA in normal marrow .
11113278	0	u-PA	80,84	urokinase-plasminogen_activator	47,78	u-PA	urokinase-plasminogen activator	5328	5328	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	Differences between neonates and adults in the urokinase-plasminogen_activator -LRB- u-PA -RRB- pathway of the fibrinolytic system .
1518351	0	u-PA	50,54	urokinase-type_plasminogen_activator	12,48	u-PA	urokinase-type plasminogen activator	102188193	102188193	Gene	Gene	Presence|appos|START_ENTITY Presence|nmod|END_ENTITY	Presence of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- in tissue extracts of antrochoanal_polyp .
1902597	0	u-PA	79,83	urokinase-type_plasminogen_activator	41,77	u-PA	urokinase-type plasminogen activator	5328	5328	Gene	Gene	levels|appos|START_ENTITY levels|amod|END_ENTITY	Physical exercise induces enhancement of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- levels in plasma .
8849586	0	u-PA	101,105	urokinase-type_plasminogen_activator	63,99	u-PA	urokinase-type plasminogen activator	396985(Tax:9823)	396985(Tax:9823)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Expression of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- and urokinase-type_plasminogen_activator -LRB- u-PA -RRB- genes during arterial repair in the pig .
21937508	0	u-PAR	14,19	H2A.Z	39,44	u-PAR	H2A.Z	5329	3015	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of u-PAR gene expression by H2A.Z is modulated by the MEK-ERK/AP -1 pathway .
18824154	0	uPA	38,41	Esophageal_Cancer-Related_Gene_2	53,85	uPA	Esophageal Cancer-Related Gene 2	5328	84651	Gene	Gene	protein|compound|START_ENTITY protein|nmod|END_ENTITY	Mapping the putative binding site for uPA protein in Esophageal_Cancer-Related_Gene_2 by heteronuclear NMR method .
11758807	0	uPA	19,22	IL-1beta	0,8	uPA	IL-1beta	5328	3553	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	IL-1beta increases uPA and uPA receptor expression in human gingival fibroblasts .
16763560	0	uPA	38,41	Plasminogen	0,11	uPA	Plasminogen	18792(Tax:10090)	18815(Tax:10090)	Gene	Gene	independent|nmod|START_ENTITY independent|compound|END_ENTITY	Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice .
11694645	0	uPA	74,77	TIMP-1	79,85	uPA	TIMP-1	5328	7076	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
11694645	0	uPA	74,77	TIMP-2	87,93	uPA	TIMP-2	5328	7077	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
26575094	0	uPA	88,91	Urokinase_Plasminogen_Activator	55,86	uPA	Urokinase Plasminogen Activator	5328	5328	Gene	Gene	Discovery|appos|START_ENTITY Discovery|nmod|END_ENTITY	Discovery and SAR of Novel and Selective Inhibitors of Urokinase_Plasminogen_Activator -LRB- uPA -RRB- with an Imidazo -LSB- 1,2-a -RSB- pyridine Scaffold .
15110861	0	uPA	65,68	Urokinase_plasminogen_activator	32,63	uPA	Urokinase plasminogen activator	5328	5328	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	3D-QSAR CoMFA/CoMSIA studies on Urokinase_plasminogen_activator -LRB- uPA -RRB- inhibitors : a strategic design in novel anticancer agents .
21091771	0	uPA	54,57	p38_MAPK	66,74	uPA	p38 MAPK	5328	1432	Gene	Gene	expression|nmod|START_ENTITY regulate|dobj|expression regulate|nmod|END_ENTITY	Integrin b3 and its ligand regulate the expression of uPA through p38_MAPK in breast_cancer .
11694645	0	uPA	74,77	p53	102,105	uPA	p53	5328	7157	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	Short-chain fatty_acids inhibit invasive human colon_cancer by modulating uPA , TIMP-1 , TIMP-2 , mutant p53 , Bcl-2 , Bax , p21 and PCNA protein expression in an in vitro cell culture model .
10896774	0	uPA	25,28	uPAR	20,24	uPA	uPAR	5328	5329	Gene	Gene	Involvement|dep|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of the -LSB- uPAR : uPA : PAI-1 : LRP -RSB- complex in human myogenic cell motility .
21798065	0	uPA	81,84	ulinastatin	11,22	uPA	ulinastatin	118471	11699(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ulinastatin and docetaxel on breast_cancer invasion and expression of uPA , uPAR and ERK .
12743986	0	uPA	62,65	urokinase-type_plasminogen_activator	24,60	uPA	urokinase-type plasminogen activator	5328	5328	Gene	Gene	value|appos|START_ENTITY value|nmod|END_ENTITY	A high cytosol value of urokinase-type_plasminogen_activator -LRB- uPA -RRB- may be predictive of early relapse in primary breast_cancer .
1526511	0	uPA	63,66	urokinase-type_plasminogen_activator	25,61	uPA	urokinase-type plasminogen activator	5328	5328	Gene	Gene	significance|appos|START_ENTITY significance|nmod|END_ENTITY	Clinical significance of urokinase-type_plasminogen_activator -LRB- uPA -RRB- in invasive_cervical_cancer_of_the_uterus .
17098546	0	uPA	49,52	urokinase-type_plasminogen_activator	11,47	uPA	urokinase-type plasminogen activator	5328	5328	Gene	Gene	transfer|compound|START_ENTITY transfer|amod|END_ENTITY	Adenoviral urokinase-type_plasminogen_activator -LRB- uPA -RRB- gene transfer enhances venous thrombus resolution .
19701247	0	uPA	88,91	urokinase-type_plasminogen_activator	50,86	uPA	urokinase-type plasminogen activator	5328	5328	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Downregulation of miR-193b contributes to enhance urokinase-type_plasminogen_activator -LRB- uPA -RRB- expression and tumor progression and invasion in human breast_cancer .
19997513	0	uPA	55,58	urokinase-type_plasminogen_activator	17,53	uPA	urokinase-type plasminogen activator	5328	5328	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A pilot study of urokinase-type_plasminogen_activator -LRB- uPA -RRB- overexpression in the brush cytology of patients with malignant pancreatic_or_biliary_strictures .
8018952	0	uPA	75,78	urokinase-type_plasminogen_activator	37,73	uPA	urokinase-type plasminogen activator	5328	5328	Gene	Gene	assay|appos|START_ENTITY assay|nmod|END_ENTITY	Enzyme-linked immunosorbent assay of urokinase-type_plasminogen_activator -LRB- uPA -RRB- in cytosolic extracts of human breast_cancer tissue .
10457348	0	uPA	47,50	urokinase_plasminogen_activator	14,45	uPA	urokinase plasminogen activator	5328	5328	Gene	Gene	activity|appos|START_ENTITY activity|amod|END_ENTITY	Regulation of urokinase_plasminogen_activator -LRB- uPA -RRB- activity by E-cadherin and hormones in mammary epithelial cells .
22013113	0	uPA	111,114	urokinase_plasminogen_activator	73,104	uPA	urokinase plasminogen activator	5328	5328	Gene	Gene	activation|compound|START_ENTITY END_ENTITY|dep|activation	Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase_plasminogen_activator -LRB- uPA -RRB- / uPA receptor-dependent activation of TGF-b and potentiates fibrosis .
9560322	0	uPA	85,88	urokinase_plasminogen_activator	52,83	uPA	urokinase plasminogen activator	18792(Tax:10090)	18792(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Synergistic transcriptional activation of the mouse urokinase_plasminogen_activator -LRB- uPA -RRB- gene and of its enhancer activator_protein_1 -LRB- AP1 -RRB- site by cAMP and retinoic_acid .
16810742	0	uPA	23,26	vascular_endothelial_growth_factor	62,96	uPA	vascular endothelial growth factor	5328	7422	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	Correlative studies on uPA mRNA and uPAR mRNA expression with vascular_endothelial_growth_factor , microvessel density , progression and survival time of patients with gastric_cancer .
15085180	0	uPAR	13,17	300_kDa_mannose_6-phosphate_receptor	63,99	uPAR	300 kDa mannose 6-phosphate receptor	5329	3482	Gene	Gene	Structure|nmod|START_ENTITY Structure|nmod|END_ENTITY	Structure of uPAR , plasminogen , and sugar-binding sites of the 300_kDa_mannose_6-phosphate_receptor .
18725541	0	uPAR	0,4	DOCK180	75,82	uPAR	DOCK180	5329	1793	Gene	Gene	promotes|nsubj|START_ENTITY promotes|nmod|END_ENTITY	uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180 .
12952933	0	uPAR	13,17	Endo180	27,34	uPAR	Endo180	5329	9902	Gene	Gene	requires|nsubj|START_ENTITY requires|dobj|END_ENTITY	GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis .
20228268	0	uPAR	45,49	Factor_XII	0,10	uPAR	Factor XII	18793(Tax:10090)	58992(Tax:10090)	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Factor_XII stimulates ERK1/2 and Akt through uPAR , integrins , and the EGFR to initiate angiogenesis .
12198772	0	uPAR	118,122	ICAM-1	59,65	uPAR	ICAM-1	50692(Tax:10116)	25464(Tax:10116)	Gene	Gene	intercellular_adhesion_molecule-1|appos|START_ENTITY intercellular_adhesion_molecule-1|appos|END_ENTITY	Decreased expression of intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and urokinase-type plasminogen activator receptor -LRB- uPAR -RRB- is associated with tumor cell spreading in vivo .
21711236	0	uPAR	38,42	LDL_receptor-related_protein-1	47,77	uPAR	LDL receptor-related protein-1	5329	4035	Gene	Gene	Regulation|appos|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the urokinase receptor -LRB- uPAR -RRB- by LDL_receptor-related_protein-1 -LRB- LRP1 -RRB- .
18718938	0	uPAR	158,162	SRPX2	112,117	uPAR	SRPX2	18793(Tax:10090)	68792(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Epileptic_and_developmental_disorders of the speech cortex : ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR .
25575713	0	uPAR	47,51	Urokinase-type_plasminogen_activator_receptor	0,45	uPAR	Urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- expression is associated with T-stage and survival in urothelial carcinoma_of_the_bladder .
16689831	0	uPAR	42,46	Urokinase_plasminogen_activator_receptor	0,40	uPAR	Urokinase plasminogen activator receptor	5329	5329	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Urokinase_plasminogen_activator_receptor -LRB- uPAR -RRB- expression is reduced by tyrosine kinase inhibitors .
25671694	0	uPAR	27,31	Vitronectin	103,114	uPAR	Vitronectin	5329	7448	Gene	Gene	Class|nmod|START_ENTITY uPA|nsubj|Class uPA|dobj|Inhibitors Inhibitors|nmod|Interaction Interaction|compound|END_ENTITY	A New Class of Orthosteric uPAR uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR Vitronectin Interaction .
25671694	0	uPAR	97,101	Vitronectin	103,114	uPAR	Vitronectin	5329	7448	Gene	Gene	Interaction|compound|START_ENTITY Interaction|compound|END_ENTITY	A New Class of Orthosteric uPAR uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR Vitronectin Interaction .
10896774	0	uPAR	20,24	uPA	25,28	uPAR	uPA	5329	5328	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of the -LSB- uPAR : uPA : PAI-1 : LRP -RSB- complex in human myogenic cell motility .
12950675	0	uPAR	116,120	uPAR	52,56	uPAR	uPAR	18793(Tax:10090)	18793(Tax:10090)	Gene	Gene	receptor|dep|START_ENTITY receptor|appos|END_ENTITY	Generation of antibodies to the urokinase receptor -LRB- uPAR -RRB- by DNA immunization of uPAR knockout mice : membrane-bound uPAR is not required for an antibody response .
12950675	0	uPAR	52,56	uPAR	116,120	uPAR	uPAR	18793(Tax:10090)	18793(Tax:10090)	Gene	Gene	receptor|appos|START_ENTITY receptor|dep|END_ENTITY	Generation of antibodies to the urokinase receptor -LRB- uPAR -RRB- by DNA immunization of uPAR knockout mice : membrane-bound uPAR is not required for an antibody response .
25671694	0	uPAR	27,31	uPAR	97,101	uPAR	uPAR	5329	5329	Gene	Gene	Class|nmod|START_ENTITY uPA|nsubj|Class uPA|dobj|Inhibitors Inhibitors|nmod|Interaction Interaction|compound|END_ENTITY	A New Class of Orthosteric uPAR uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR Vitronectin Interaction .
25671694	0	uPAR	97,101	uPAR	27,31	uPAR	uPAR	5329	5329	Gene	Gene	Interaction|compound|START_ENTITY Inhibitors|nmod|Interaction uPA|dobj|Inhibitors uPA|nsubj|Class Class|nmod|END_ENTITY	A New Class of Orthosteric uPAR uPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPAR Vitronectin Interaction .
19717562	0	uPAR	91,95	urokinase-type_plasmin_activator_receptor	48,89	uPAR	urokinase-type plasmin activator receptor	5329	5329	Gene	Gene	pathway|appos|START_ENTITY pathway|amod|END_ENTITY	ECRG2 regulates cell migration/invasion through urokinase-type_plasmin_activator_receptor -LRB- uPAR -RRB- / beta1_integrin pathway .
10339491	0	uPAR	149,153	urokinase-type_plasminogen_activator	72,108	uPAR	urokinase-type plasminogen activator	5329	5328	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Characterization of cell-associated plasminogen activation catalyzed by urokinase-type_plasminogen_activator , but independent of urokinase receptor -LRB- uPAR , CD87 -RRB- .
11437407	0	uPAR	68,72	urokinase-type_plasminogen_activator	21,57	uPAR	urokinase-type plasminogen activator	5328	5328	Gene	Gene	receptor|appos|START_ENTITY receptor|amod|END_ENTITY	Prognostic impact of urokinase-type_plasminogen_activator receptor -LRB- uPAR -RRB- in cytosols and pellet extracts derived from primary breast_tumours .
9165076	0	uPAR	95,99	urokinase-type_plasminogen_activator	33,69	uPAR	urokinase-type plasminogen activator	5329	5328	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|interaction interaction|nmod|uPA uPA|amod|END_ENTITY	Inhibition of the interaction of urokinase-type_plasminogen_activator -LRB- uPA -RRB- with its receptor -LRB- uPAR -RRB- by synthetic peptides .
10417621	0	uPAR	61,65	urokinase-type_plasminogen_activator_receptor	14,59	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	UVB increases urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- expression .
12665524	0	uPAR	58,62	urokinase-type_plasminogen_activator_receptor	11,56	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	Binding|appos|START_ENTITY Binding|nmod|END_ENTITY	Binding of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- to the mannose_6-phosphate / insulin-like growth factor II receptor : contrasting interactions of full-length and soluble forms of uPAR .
15543615	0	uPAR	91,95	urokinase-type_plasminogen_activator_receptor	44,89	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	Real-time quantitative PCR determination of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- expression of isolated micrometastatic cells from bone marrow of breast_cancer patients .
15894933	0	uPAR	61,65	urokinase-type_plasminogen_activator_receptor	14,59	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- in primary central_nervous_system_neoplasms .
18189329	0	uPAR	180,184	urokinase-type_plasminogen_activator_receptor	133,178	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Endothelial cells and normal breast epithelial cells enhance invasion of breast_carcinoma cells by CXCR-4-dependent up-regulation of urokinase-type_plasminogen_activator_receptor -LRB- uPAR , CD87 -RRB- expression .
19435784	0	uPAR	68,72	urokinase-type_plasminogen_activator_receptor	21,66	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Amplification of the urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- gene in ductal pancreatic_carcinomas identifies a clinically high-risk group .
23852693	0	uPAR	63,67	urokinase-type_plasminogen_activator_receptor	16,61	uPAR	urokinase-type plasminogen activator receptor	18793(Tax:10090)	18793(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Inactivation of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- gene induces dermal and pulmonary_fibrosis_and_peripheral_microvasculopathy in mice : a new model of experimental scleroderma ?
24474395	0	uPAR	72,76	urokinase-type_plasminogen_activator_receptor	25,70	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	study|appos|START_ENTITY study|nmod|END_ENTITY	A retrospective study of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- as a prognostic factor in cancer_of_the_uterine_cervix .
9846056	0	uPAR	82,86	urokinase-type_plasminogen_activator_receptor	35,80	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and localization of the urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- in the human placenta .
9869396	0	uPAR	69,73	urokinase-type_plasminogen_activator_receptor	22,67	uPAR	urokinase-type plasminogen activator receptor	5329	5329	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Stromal expression of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- is associated with invasive_growth in primary_liver_cancer .
11313929	0	uPAR	95,99	urokinase_plasminogen_activator_receptor	53,93	uPAR	urokinase plasminogen activator receptor	5329	5329	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	The small-GTPase RalA activates transcription of the urokinase_plasminogen_activator_receptor -LRB- uPAR -RRB- gene via an AP1-dependent mechanism .
16756681	0	uPAR	60,64	urokinase_receptor	40,58	uPAR	urokinase receptor	5329	5329	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The superoxide scavenger TEMPOL induces urokinase_receptor -LRB- uPAR -RRB- expression in human prostate_cancer cells .
16893520	0	uPAR	81,85	urokinase_type_plasminogen_activator_receptor	34,79	uPAR	urokinase type plasminogen activator receptor	5329	5329	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Aspirin upregulates expression of urokinase_type_plasminogen_activator_receptor -LRB- uPAR -RRB- gene in human colon_cancer cells through AP1 .
10722842	0	uPAR	36,40	vitronectin	88,99	uPAR	vitronectin	18793(Tax:10090)	22370(Tax:10090)	Gene	Gene	urokinase_receptor|appos|START_ENTITY Domain|nmod|urokinase_receptor required|nsubjpass|Domain required|nmod|cell cell|nmod|END_ENTITY	Domain 1 of the urokinase_receptor -LRB- uPAR -RRB- is required for uPAR-mediated cell binding to vitronectin .
7528215	2	uPAR	304,308	vitronectin	360,371	uPAR	vitronectin	5329	7448	Gene	Gene	urokinase_receptor|appos|START_ENTITY receptor|nsubj|urokinase_receptor receptor|nmod|END_ENTITY	We now report that the urokinase_receptor -LRB- uPAR -RRB- is also a high affinity -LRB- Kd < 30 nM -RRB- receptor for vitronectin .
17947293	0	ubiquilin	0,9	presenilin	22,32	ubiquilin	presenilin	32977(Tax:7227)	40260(Tax:7227)	Gene	Gene	antagonizes|nsubj|START_ENTITY antagonizes|dobj|END_ENTITY	ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila .
9491072	0	ubiquitin	22,31	Grr1	0,4	ubiquitin	Grr1	850620(Tax:4932)	853552(Tax:4932)	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Grr1 functions in the ubiquitin pathway in Saccharomyces_cerevisiae through association with Skp1 .
16407276	0	ubiquitin	58,67	Rabex-5	44,51	ubiquitin	Rabex-5	850620(Tax:4932)	27342	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	The Rab5 guanine_nucleotide exchange factor Rabex-5 binds ubiquitin -LRB- Ub -RRB- and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain .
12654912	0	ubiquitin	17,26	Vps9p	0,5	ubiquitin	Vps9p	850620(Tax:4932)	854876(Tax:4932)	Gene	Gene	binding|compound|START_ENTITY binding|compound|END_ENTITY	Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic .
1544321	0	ubiquitin-activating_enzyme_E1	10,40	UBE1	47,51	ubiquitin-activating enzyme E1	UBE1	7318	7318	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The human ubiquitin-activating_enzyme_E1 gene -LRB- UBE1 -RRB- mapped to band Xp11 .3 -- p11 .23 by fluorescence in situ hybridization .
1617221	0	ubiquitin-activating_enzyme_E1	30,60	Ube1	62,66	ubiquitin-activating enzyme E1	Ube1	22201(Tax:10090)	22201(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mapping and expression of the ubiquitin-activating_enzyme_E1 -LRB- Ube1 -RRB- gene in the mouse .
16129784	0	ubiquitin-conjugating_enzyme	50,78	Ubc13	23,28	ubiquitin-conjugating enzyme	Ubc13	7316	7334	Gene	Gene	functions|nmod|START_ENTITY functions|amod|END_ENTITY	Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating_enzyme variants Mms2 and Uev1A .
18331723	0	ubiquitin-conjugating_enzyme_E2C	14,46	UbcH10	47,53	ubiquitin-conjugating enzyme E2C	UbcH10	11065	11065	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of ubiquitin-conjugating_enzyme_E2C / UbcH10 in astrocytic_tumors .
19189687	0	ubiquitin-like_5	49,65	UBL5	43,47	ubiquitin-like 5	UBL5	59286	59286	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Identification of sequence variants in the UBL5 -LRB- ubiquitin-like_5 or BEACON -RRB- gene in obese children by PCR-SSCP : no evidence for association with obesity .
24458823	0	ubiquitin-like_5	8,24	UBL5	26,30	ubiquitin-like 5	UBL5	100513004	100513004	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Porcine ubiquitin-like_5 -LRB- UBL5 -RRB- gene : genomic organization , polymorphisms , mRNA cloning , splicing variants and association study .
20111060	0	ubiquitin-specific_peptidase_46	21,52	USP46	54,59	ubiquitin-specific peptidase 46	USP46	69727(Tax:10090)	69727(Tax:10090)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Association study of ubiquitin-specific_peptidase_46 -LRB- USP46 -RRB- with bipolar_disorder and schizophrenia in a Japanese population .
25981749	0	ubiquitin-specific_protease_18	77,107	USP18	109,114	ubiquitin-specific protease 18	USP18	100334535(Tax:7955)	100334535(Tax:7955)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Expression characterization , genomic structure and function analysis of fish ubiquitin-specific_protease_18 -LRB- USP18 -RRB- genes .
19995917	0	ubiquitin-specific_protease_7	51,80	GMP_synthetase	20,34	ubiquitin-specific protease 7	GMP synthetase	32169(Tax:7227)	45830(Tax:7227)	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	Biosynthetic enzyme GMP_synthetase cooperates with ubiquitin-specific_protease_7 in transcriptional regulation of ecdysteroid target genes .
17449248	0	ubiquitin_C-terminal_hydrolase-L1	87,120	UCH-L1	122,128	ubiquitin C-terminal hydrolase-L1	UCH-L1	7345	7345	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Structure-activity relationship , kinetic mechanism , and selectivity for a new class of ubiquitin_C-terminal_hydrolase-L1 -LRB- UCH-L1 -RRB- inhibitors .
18985619	0	ubiquitin_C-terminal_hydrolase-L1	28,61	UCH-L1	63,69	ubiquitin C-terminal hydrolase-L1	UCH-L1	7345	7345	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A new role for the neuronal ubiquitin_C-terminal_hydrolase-L1 -LRB- UCH-L1 -RRB- in podocyte process formation and podocyte injury in human glomerulopathies .
21309726	0	ubiquitin_C-terminal_hydrolase-L1	23,56	UCH-L1	58,64	ubiquitin C-terminal hydrolase-L1	UCH-L1	7345	7345	Gene	Gene	analysis|nmod|START_ENTITY analysis|appos|END_ENTITY	Biokinetic analysis of ubiquitin_C-terminal_hydrolase-L1 -LRB- UCH-L1 -RRB- in severe traumatic_brain_injury patient biofluids .
23996067	0	ubiquitin_C-terminal_hydrolase_L1	24,57	UCH-L1	59,65	ubiquitin C-terminal hydrolase L1	UCH-L1	7345	7345	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Prognostic relevance of ubiquitin_C-terminal_hydrolase_L1 -LRB- UCH-L1 -RRB- mRNA and protein expression in breast_cancer patients .
10900392	0	ubiquitin_carboxy-terminal_hydrolase_L1	38,77	UCH-L1	79,85	ubiquitin carboxy-terminal hydrolase L1	UCH-L1	7345	7345	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between a polymorphism of ubiquitin_carboxy-terminal_hydrolase_L1 -LRB- UCH-L1 -RRB- gene and sporadic Parkinson 's _ disease .
24950120	0	ubiquitin_carboxy-terminal_hydrolase_L1	60,99	UCHL1	101,106	ubiquitin carboxy-terminal hydrolase L1	UCHL1	7345	7345	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin_carboxy-terminal_hydrolase_L1 -LRB- UCHL1 -RRB- expression in the pathogenesis of Alzheimer 's _ disease .
11979512	0	ubiquitin_fusion_degradation_1_like	63,98	UFD1L	105,110	ubiquitin fusion degradation 1 like	UFD1L	7353	7353	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional characterization of the 5 ' flanking region of human ubiquitin_fusion_degradation_1_like gene -LRB- UFD1L -RRB- .
18501710	0	ubiquitin_ligase	4,20	WWP1	27,31	ubiquitin ligase	WWP1	422131(Tax:9031)	420212(Tax:9031)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The ubiquitin_ligase gene -LRB- WWP1 -RRB- is responsible for the chicken muscular_dystrophy .
25084275	0	ubiquitin_protein_ligase_E3_component_N-recognin_4	47,97	UBR4	99,103	ubiquitin protein ligase E3 component N-recognin 4	UBR4	69116(Tax:10090)	69116(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Time-of-day - and light-dependent expression of ubiquitin_protein_ligase_E3_component_N-recognin_4 -LRB- UBR4 -RRB- in the suprachiasmatic nucleus circadian clock .
15354349	0	ubiquitin_specific_protease_31	28,58	USP31	60,65	ubiquitin specific protease 31	USP31	84196	84196	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of the human ubiquitin_specific_protease_31 -LRB- USP31 -RRB- gene : structure , sequence and expression analysis .
20302626	0	ubiquitous_mitochondrial_creatine_kinase	20,60	ASB9	0,4	ubiquitous mitochondrial creatine kinase	ASB9	1159	140462	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ASB9 interacts with ubiquitous_mitochondrial_creatine_kinase and inhibits mitochondrial function .
21878341	0	ucp2	85,89	uncoupling_protein_2	63,83	ucp2	uncoupling protein 2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Alterations in anxiety-like behavior following knockout of the uncoupling_protein_2 -LRB- ucp2 -RRB- gene in mice .
8818087	0	ulinastatin	20,31	CRP	42,45	ulinastatin	CRP	259	1401	Gene	Gene	Changes|nmod|START_ENTITY END_ENTITY|nsubj|Changes	-LSB- Changes of urinary ulinastatin and serum CRP after elective surgery for gastric_cancer -RSB- .
20819433	0	ulinastatin	11,22	CXC_chemokine_receptor_4_and_matrix_metalloproteinase-9	103,158	ulinastatin	CXC chemokine receptor 4 and matrix metalloproteinase-9	11699(Tax:10090)	17395(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ulinastatin and cyclophosphamide on the growth of xenograft breast_cancer and expression of CXC_chemokine_receptor_4_and_matrix_metalloproteinase-9 in cancers .
21798065	0	ulinastatin	11,22	uPA	81,84	ulinastatin	uPA	11699(Tax:10090)	118471	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of ulinastatin and docetaxel on breast_cancer invasion and expression of uPA , uPAR and ERK .
15039447	0	ultrabithorax	25,38	Hox	0,3	ultrabithorax	Hox	42034(Tax:7227)	42536(Tax:7227)	Gene	Gene	Ib|compound|START_ENTITY Ib|compound|END_ENTITY	Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected_interacting_protein_1 , a double-stranded RNA-binding protein .
17050628	0	ultrabithorax	4,17	Hox	18,21	ultrabithorax	Hox	42034(Tax:7227)	42536(Tax:7227)	Gene	Gene	gene|amod|START_ENTITY gene|compound|END_ENTITY	The ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway .
2754728	0	unc-15	17,23	Paramyosin	0,10	unc-15	Paramyosin	172491(Tax:6239)	172491(Tax:6239)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Paramyosin gene -LRB- unc-15 -RRB- of Caenorhabditis_elegans .
7472434	0	unc-33	86,92	TOAD-64	0,7	unc-33	TOAD-64	177112(Tax:6239)	25416(Tax:10116)	Gene	Gene	related|nmod|START_ENTITY related|nsubjpass|END_ENTITY	TOAD-64 , a gene expressed early in neuronal differentiation in the rat , is related to unc-33 , a C. _ elegans gene involved in axon outgrowth .
15329462	0	uncoupling_protein-1	39,59	UCP1	61,65	uncoupling protein-1	UCP1	22227(Tax:10090)	22227(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Effects of ethanol on the induction of uncoupling_protein-1 -LRB- UCP1 -RRB- mRNA in the mouse brown adipose tissue .
18839467	0	uncoupling_protein-2	23,43	UCP2	45,49	uncoupling protein-2	UCP2	7351	7351	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role for mitochondrial uncoupling_protein-2 -LRB- UCP2 -RRB- in hyperhomocysteinemia and venous_thrombosis risk ?
23088859	0	uncoupling_protein-2	37,57	UCP2	59,63	uncoupling protein-2	UCP2	7351	7351	Gene	Gene	Localisation|nmod|START_ENTITY Localisation|appos|END_ENTITY	Localisation and characterisation of uncoupling_protein-2 -LRB- UCP2 -RRB- in the human preterm placenta .
10027754	0	uncoupling_protein-2	61,81	hUCP2	83,88	uncoupling protein-2	hUCP2	7351	7351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Structural organization and mutational analysis of the human uncoupling_protein-2 -LRB- hUCP2 -RRB- gene .
24642125	0	uncoupling_protein-2	76,96	hnRNP-K	24,31	uncoupling protein-2	hnRNP-K	7351	3190	Gene	Gene	regulation|nmod|START_ENTITY mediates|dobj|regulation mediates|nsubj|END_ENTITY	The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling_protein-2 by angiopoietin-1 .
9177227	0	uncoupling_protein-2	23,43	leptin	13,19	uncoupling protein-2	leptin	54315(Tax:10116)	25608(Tax:10116)	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction by leptin of uncoupling_protein-2 and enzymes of fatty_acid oxidation .
10454128	0	uncoupling_protein-3	32,52	UCP3	54,58	uncoupling protein-3	UCP3	7352	7352	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Uncoupling_protein-2 -LRB- UCP2 -RRB- and uncoupling_protein-3 -LRB- UCP3 -RRB- expression in adipose tissue and skeletal muscle in humans .
9618150	0	uncoupling_protein_1	67,87	IGF-I	41,46	uncoupling protein 1	IGF-I	7350	3479	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling_protein_1 gene expression in brown adipocytes .
17456798	0	uncoupling_protein_1	57,77	Receptor_interacting_protein_140	0,32	uncoupling protein 1	Receptor interacting protein 140	7350	8204	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Receptor_interacting_protein_140 regulates expression of uncoupling_protein_1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha .
24825887	0	uncoupling_protein_1	18,38	Sestrin2	0,8	uncoupling protein 1	Sestrin2	7350	83667	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Sestrin2 inhibits uncoupling_protein_1 expression through suppressing reactive oxygen species .
11369767	0	uncoupling_protein_1	82,102	UCP1	104,108	uncoupling protein 1	UCP1	7350	7350	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	beta-Adrenergic activation of p38_MAP_kinase in adipocytes : cAMP induction of the uncoupling_protein_1 -LRB- UCP1 -RRB- gene requires p38_MAP_kinase .
16933999	0	uncoupling_protein_1	4,24	UCP1	31,35	uncoupling protein 1	UCP1	751863(Tax:9823)	751863(Tax:9823)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The uncoupling_protein_1 gene -LRB- UCP1 -RRB- is disrupted in the pig lineage : a genetic explanation for poor thermoregulation in piglets .
22790465	0	uncoupling_protein_1	16,36	UCP1	38,42	uncoupling protein 1	UCP1	7350	7350	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of the uncoupling_protein_1 -LRB- UCP1 -RRB- on the development of obesity and type_2_diabetes_mellitus .
9665669	0	uncoupling_protein_1	24,44	UCP1	46,50	uncoupling protein 1	UCP1	7350	7350	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	DNA polymorphism in the uncoupling_protein_1 -LRB- UCP1 -RRB- gene has no effect on obesity related phenotypes in the Swedish Obese Subjects cohorts .
11784294	0	uncoupling_protein_1	18,38	aP2	48,51	uncoupling protein 1	aP2	22227(Tax:10090)	21418(Tax:10090)	Gene	Gene	START_ENTITY|nmod|promoter promoter|amod|END_ENTITY	Expression of the uncoupling_protein_1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo .
23625627	0	uncoupling_protein_2	51,71	Forkhead_box_protein_A1	0,23	uncoupling protein 2	Forkhead box protein A1	7351	3169	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Forkhead_box_protein_A1 inhibits the expression of uncoupling_protein_2 in hydrogen_peroxide-induced A549 cell line .
22318764	0	uncoupling_protein_2	62,82	Peroxisome_proliferator-activated_receptor_alpha	0,48	uncoupling protein 2	Peroxisome proliferator-activated receptor alpha	22228(Tax:10090)	19013(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Peroxisome_proliferator-activated_receptor_alpha induction of uncoupling_protein_2 protects against acetaminophen-induced liver toxicity .
25077985	0	uncoupling_protein_2	48,68	TNF-alpha	23,32	uncoupling protein 2	TNF-alpha	22228(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY effect|nmod|expression effect|nmod|END_ENTITY	Antagonistic effect of TNF-alpha and insulin on uncoupling_protein_2 -LRB- UCP-2 -RRB- expression and vascular_damage .
12756242	0	uncoupling_protein_2	158,178	UCP-2	180,185	uncoupling protein 2	UCP-2	54315(Tax:10116)	54315(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling_protein_2 -LRB- UCP-2 -RRB- expression : evidence for peroxisome_proliferator-activated_receptor-alpha independent induction of UCP-2 expression .
17916951	0	uncoupling_protein_2	166,186	UCP-2	188,193	uncoupling protein 2	UCP-2	7351	7351	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Increased plasma manganese , partially reduced ascorbate , 1 and absence of mitochondrial oxidative stress in type 2 diabetes_mellitus : implications for the superoxide uncoupling_protein_2 -LRB- UCP-2 -RRB- pathway .
25077985	0	uncoupling_protein_2	48,68	UCP-2	70,75	uncoupling protein 2	UCP-2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Antagonistic effect of TNF-alpha and insulin on uncoupling_protein_2 -LRB- UCP-2 -RRB- expression and vascular_damage .
10849580	0	uncoupling_protein_2	61,81	UCP2	83,87	uncoupling protein 2	UCP2	7351	7351	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Depot-related and thiazolidinedione-responsive expression of uncoupling_protein_2 -LRB- UCP2 -RRB- in human adipocytes .
15231722	0	uncoupling_protein_2	8,28	UCP2	30,34	uncoupling protein 2	UCP2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Role of uncoupling_protein_2 -LRB- UCP2 -RRB- expression and 1alpha , 25-dihydroxyvitamin_D3 in modulating adipocyte apoptosis .
21779625	0	uncoupling_protein_2	12,32	UCP2	34,38	uncoupling protein 2	UCP2	7351	7351	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of uncoupling_protein_2 -LRB- UCP2 -RRB- on the development of type_2_diabetes_mellitus and its chronic complications .
22134120	0	uncoupling_protein_2	53,73	UCP2	75,79	uncoupling protein 2	UCP2	7351	7351	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The presence of the -866 A/55Val/Ins haplotype in the uncoupling_protein_2 -LRB- UCP2 -RRB- gene is associated with decreased UCP2 gene expression in human retina .
23314523	0	uncoupling_protein_2	14,34	UCP2	36,40	uncoupling protein 2	UCP2	7351	7351	Gene	Gene	associated|nsubjpass|START_ENTITY associated|dep|END_ENTITY	Mitochondrial uncoupling_protein_2 -LRB- UCP2 -RRB- gene polymorphisms are associated with childhood obesity and related metabolic_disorders .
9710252	0	uncoupling_protein_2	56,76	UCP2	78,82	uncoupling protein 2	UCP2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genomic organization and promoter function of the mouse uncoupling_protein_2 -LRB- UCP2 -RRB- gene .
22266335	0	uncoupling_protein_2	36,56	hUCP2	58,63	uncoupling protein 2	hUCP2	7351	7351	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	A neuroprotective role of the human uncoupling_protein_2 -LRB- hUCP2 -RRB- in a Drosophila Parkinson 's _ disease model .
24965893	0	uncoupling_protein_2	36,56	hUCP2	58,63	uncoupling protein 2	hUCP2	7351	7351	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The neuroprotective effect of human uncoupling_protein_2 -LRB- hUCP2 -RRB- requires cAMP-dependent protein kinase in a toxin model of Parkinson 's _ disease .
21878341	0	uncoupling_protein_2	63,83	ucp2	85,89	uncoupling protein 2	ucp2	22228(Tax:10090)	22228(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Alterations in anxiety-like behavior following knockout of the uncoupling_protein_2 -LRB- ucp2 -RRB- gene in mice .
10329378	0	uncoupling_protein_3	68,88	UCP3	90,94	uncoupling protein 3	UCP3	7352	7352	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of the 5 ' flanking region of the human uncoupling_protein_3 -LRB- UCP3 -RRB- gene .
11151767	0	uncoupling_protein_3	52,72	UCP3	74,78	uncoupling protein 3	UCP3	7352	7352	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Evidence that single nucleotide polymorphism in the uncoupling_protein_3 -LRB- UCP3 -RRB- gene influences fat distribution in women of European and Asian origin .
22811361	0	uncoupling_protein_3	39,59	UCP3	61,65	uncoupling protein 3	UCP3	7352	7352	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Relationship of -55 C/T polymorphism of uncoupling_protein_3 -LRB- UCP3 -RRB- gene with metabolic_syndrome by ATP III classification .
9642158	0	uncoupling_protein_3	17,37	UCP3	39,43	uncoupling protein 3	UCP3	22229(Tax:10090)	22229(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Up-regulation of uncoupling_protein_3 -LRB- UCP3 -RRB- mRNA by exercise training and down-regulation of UCP3 by denervation in skeletal muscles .
12163152	0	uncoupling_protein_3	22,42	mitochondrial_thioesterase-1	69,97	uncoupling protein 3	mitochondrial thioesterase-1	25708(Tax:10116)	192272(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY associated|nsubjpass|expression associated|nmod|expression expression|amod|END_ENTITY	De novo expression of uncoupling_protein_3 is associated to enhanced mitochondrial_thioesterase-1 expression and fatty_acid metabolism in liver of fenofibrate-treated rats .
15650878	0	ung	95,98	msh2	103,107	ung	msh2	7374	4436	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The mutation spectrum of purified AID is similar to the mutability index in Ramos cells and in ung -LRB- - / - -RRB- msh2 -LRB- - / - -RRB- mice .
16894013	0	ung	111,114	msh2	103,107	ung	msh2	22256(Tax:10090)	17685(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY mice|amod|END_ENTITY	The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2 - / - ung - / - mice .
8934551	0	unr	21,24	ALL-1	0,5	unr	ALL-1	7812	100310785	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	ALL-1 interacts with unr , a protein containing multiple cold shock domains .
10226592	0	up-regulated_in_metastasis	37,63	URIM	18,22	up-regulated in metastasis	URIM	64976	64976	Gene	Gene	START_ENTITY|nsubj|Identification Identification|nmod|END_ENTITY	Identification of URIM , a novel gene up-regulated_in_metastasis .
17289164	0	upstream_stimulating_factor	34,61	IL-10	14,19	upstream stimulating factor	IL-10	7391	3586	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Regulation of IL-10 expression by upstream_stimulating_factor -LRB- USF-1 -RRB- in glioma-associated microglia .
17289164	0	upstream_stimulating_factor	34,61	USF-1	63,68	upstream stimulating factor	USF-1	7391	7391	Gene	Gene	expression|nmod|START_ENTITY Regulation|nmod|expression Regulation|appos|END_ENTITY	Regulation of IL-10 expression by upstream_stimulating_factor -LRB- USF-1 -RRB- in glioma-associated microglia .
11557042	0	upstream_stimulatory_factor	87,114	DNA_topoisomerase_III_alpha	40,67	upstream stimulatory factor	DNA topoisomerase III alpha	7391	7156	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|expression expression|compound|END_ENTITY	Cell type-dependent regulation of human DNA_topoisomerase_III_alpha gene expression by upstream_stimulatory_factor 2 .
8486371	0	upstream_stimulatory_factor	34,61	USF	63,66	upstream stimulatory factor	USF	7391	7391	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of the gene-encoding upstream_stimulatory_factor -LRB- USF -RRB- to human chromosome 1q22-q23 .
24747958	0	uracil-DNA_glycosylase	30,52	E2A	70,73	uracil-DNA glycosylase	E2A	7374	6929	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression and recruitment of uracil-DNA_glycosylase are regulated by E2A during antibody diversification .
11104908	0	uracil-DNA_glycosylase	32,54	UNG	56,59	uracil-DNA glycosylase	UNG	7374	7374	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Sequence variation in the human uracil-DNA_glycosylase -LRB- UNG -RRB- gene .
19411194	0	uracil-DNA_glycosylase	84,106	UNG	108,111	uracil-DNA glycosylase	UNG	7374	7374	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA_glycosylase -LRB- UNG -RRB- gene through a mechanism involving derepression .
7819187	0	uracil-DNA_glycosylase	34,56	UNG	66,69	uracil-DNA glycosylase	UNG	7374	7374	Gene	Gene	START_ENTITY|nmod|gene gene|compound|END_ENTITY	Properties of a recombinant human uracil-DNA_glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA_glycosylase .
16216562	0	uracil-DNA_glycosylase	53,75	proliferating_cell_nuclear_antigen	81,115	uracil-DNA glycosylase	proliferating cell nuclear antigen	7374	5111	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Physical and functional interaction of human nuclear uracil-DNA_glycosylase with proliferating_cell_nuclear_antigen .
18973764	0	uracil-DNA_glycosylase	50,72	ribosomal_protein_S3	6,26	uracil-DNA glycosylase	ribosomal protein S3	7374	6188	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Human ribosomal_protein_S3 -LRB- hRpS3 -RRB- interacts with uracil-DNA_glycosylase -LRB- hUNG -RRB- and stimulates its glycosylase activity .
16326701	0	uracil_DNA_glycosylase	15,37	A20	57,60	uracil DNA glycosylase	A20	7374	28935	Gene	Gene	START_ENTITY|nmod|protein protein|compound|END_ENTITY	Vaccinia_virus uracil_DNA_glycosylase interacts with the A20 protein to form a heterodimeric processivity factor for the viral DNA polymerase .
12565992	0	uracil_DNA_glycosylase	14,36	UDG	38,41	uracil DNA glycosylase	UDG	7374	7374	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of uracil_DNA_glycosylase -LRB- UDG -RRB- does not affect cellular sensitivity to thymidylate_synthase -LRB- TS -RRB- inhibition .
1924305	0	uracil_DNA_glycosylase	16,38	glyceraldehyde-3-phosphate_dehydrogenase	64,104	uracil DNA glycosylase	glyceraldehyde-3-phosphate dehydrogenase	7374	2597	Gene	Gene	subunit|nsubj|START_ENTITY subunit|nmod|END_ENTITY	A human nuclear uracil_DNA_glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate_dehydrogenase .
16703794	0	urate_transporter_1	29,48	URAT1	50,55	urate transporter 1	URAT1	116085	116085	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Analysis of mutations in the urate_transporter_1 -LRB- URAT1 -RRB- gene of Japanese patients with hypouricemia in northern Japan and review of the literature .
19833602	0	urate_transporter_1	54,73	hURAT1	75,81	urate transporter 1	hURAT1	116085	116085	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Multiple single_nucleotide_polymorphisms in the human urate_transporter_1 -LRB- hURAT1 -RRB- gene are associated with hyperuricaemia in Han Chinese .
23298683	0	uridine_diphosphate_glycosyltransferase	39,78	UGT	80,83	uridine diphosphate glycosyltransferase	UGT	7361	7361	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Functional and structural variation of uridine_diphosphate_glycosyltransferase -LRB- UGT -RRB- gene of Stevia rebaudiana-UGTSr involved in the synthesis of rebaudioside_A .
19602572	0	uridine_phosphorylase	169,190	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha	0,67	uridine phosphorylase	Peroxisome proliferator-activated receptor gamma coactivator-1alpha	7378	10891	Gene	Gene	induction|nmod|START_ENTITY enhances|nmod|induction enhances|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor_gamma_coactivator-1alpha enhances antiproliferative activity of 5 ' - deoxy-5-fluorouridine in cancer cells through induction of uridine_phosphorylase .
8144524	0	urinary-type_plasminogen_activator	48,82	mast_cell_tryptase	6,24	urinary-type plasminogen activator	mast cell tryptase	5328	25823	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Human mast_cell_tryptase activates single-chain urinary-type_plasminogen_activator -LRB- pro-urokinase -RRB- .
14555790	0	urocortin	27,36	CT-1	59,63	urocortin	CT-1	7349	1489	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|nmod|END_ENTITY	The cardioprotective agent urocortin induces expression of CT-1 .
10650129	0	urocortin	104,113	Fos	0,3	urocortin	Fos	29151(Tax:10116)	314322(Tax:10116)	Gene	Gene	injection|nmod|START_ENTITY induction|nmod|injection induction|nsubj|END_ENTITY	Fos induction in selective hypothalamic neuroendocrine and medullary nuclei by intravenous injection of urocortin and corticotropin-releasing_factor in rats .
12887419	0	urocortin	14,23	Fos	58,61	urocortin	Fos	22226(Tax:10090)	14281(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY END_ENTITY|nsubj|effect	The effect of urocortin on ingestive behaviours and brain Fos immunoreactivity in mice .
17952632	0	urocortin	62,71	Stat3	43,48	urocortin	Stat3	7349	6774	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Unexpected amplification of leptin-induced Stat3 signaling by urocortin : implications for obesity .
16488667	0	urocortin	23,32	angiotensin-converting_enzyme	36,65	urocortin	angiotensin-converting enzyme	29151(Tax:10116)	24310(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of intravenous urocortin on angiotensin-converting_enzyme in rats .
20237592	0	urocortin	35,44	angiotensin-converting_enzyme	72,101	urocortin	angiotensin-converting enzyme	29151(Tax:10116)	24310(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|activity activity|nmod|END_ENTITY	Effect of long-term treatment with urocortin on the activity of somatic angiotensin-converting_enzyme in spontaneously hypertensive rats .
25189177	0	urocortin	36,45	corticotrophin-releasing_factor	4,35	urocortin	corticotrophin-releasing factor	22226(Tax:10090)	12917(Tax:10090)	Gene	Gene	system|compound|START_ENTITY regulates|nsubj|system END_ENTITY|parataxis|regulates	The corticotrophin-releasing_factor / urocortin system regulates white fat browning in mice through paracrine mechanisms .
12746287	0	urocortin	61,70	corticotropin-releasing_hormone	28,59	urocortin	corticotropin-releasing hormone	7349	1392	Gene	Gene	levels|appos|START_ENTITY levels|nmod|END_ENTITY	High levels of intrauterine corticotropin-releasing_hormone , urocortin , tryptase , and interleukin-8 in spontaneous_abortions .
19232696	0	urocortin	107,116	urocortin	27,36	urocortin	urocortin	7349	7349	Gene	Gene	role|nmod|START_ENTITY expression|dep|role expression|nmod|END_ENTITY	Differential expression of urocortin in human testicular germ cells in course of spermatogenesis : role for urocortin in male fertility ?
19232696	0	urocortin	27,36	urocortin	107,116	urocortin	urocortin	7349	7349	Gene	Gene	expression|nmod|START_ENTITY expression|dep|role role|nmod|END_ENTITY	Differential expression of urocortin in human testicular germ cells in course of spermatogenesis : role for urocortin in male fertility ?
15070962	0	urocortin_III	14,27	stresscopin	28,39	urocortin III	stresscopin	114131	114131	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of urocortin_III / stresscopin in human heart and kidney .
21106860	0	uroguanylin	121,132	GC-C	103,107	uroguanylin	GC-C	64055(Tax:10116)	25711(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	The rat kidney contains high levels of prouroguanylin -LRB- the uroguanylin precursor -RRB- but does not express GC-C -LRB- the enteric uroguanylin receptor -RRB- .
9344659	0	uroguanylin	4,15	Guca1b	22,28	uroguanylin	Guca1b	14916(Tax:10090)	107477(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The uroguanylin gene -LRB- Guca1b -RRB- is linked to guanylin -LRB- Guca2 -RRB- on mouse chromosome 4 .
11113278	0	urokinase-plasminogen_activator	47,78	u-PA	80,84	urokinase-plasminogen activator	u-PA	5328	5328	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	Differences between neonates and adults in the urokinase-plasminogen_activator -LRB- u-PA -RRB- pathway of the fibrinolytic system .
19717562	0	urokinase-type_plasmin_activator_receptor	48,89	uPAR	91,95	urokinase-type plasmin activator receptor	uPAR	5329	5329	Gene	Gene	pathway|amod|START_ENTITY pathway|appos|END_ENTITY	ECRG2 regulates cell migration/invasion through urokinase-type_plasmin_activator_receptor -LRB- uPAR -RRB- / beta1_integrin pathway .
11583973	0	urokinase-type_plasminogen_activator	25,61	Angiotensin_II	0,14	urokinase-type plasminogen activator	Angiotensin II	5328	11606(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases urokinase-type_plasminogen_activator expression and induces aneurysm in the abdominal aorta of apolipoprotein_E-deficient mice .
17013094	0	urokinase-type_plasminogen_activator	21,57	Autotaxin	0,9	urokinase-type plasminogen activator	Autotaxin	5328	5168	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Autotaxin stimulates urokinase-type_plasminogen_activator expression through phosphoinositide_3-kinase-Akt-nuclear -LSB- corrected -RSB- factor kappa B signaling cascade in human melanoma cells .
21567400	0	urokinase-type_plasminogen_activator	83,119	CXC_receptor_4	30,44	urokinase-type plasminogen activator	CXC receptor 4	5328	7852	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Stromal_cell-derived_factor-1 / CXC_receptor_4 and b1 integrin interaction regulates urokinase-type_plasminogen_activator expression in human colorectal_cancer cells .
1900515	0	urokinase-type_plasminogen_activator	102,138	Cathepsin_B	0,11	urokinase-type plasminogen activator	Cathepsin B	5328	1508	Gene	Gene	form|nmod|START_ENTITY activates|dobj|form activates|nsubj|efficiently efficiently|compound|END_ENTITY	Cathepsin_B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type_plasminogen_activator -LRB- Pro-uPA -RRB- .
11399944	0	urokinase-type_plasminogen_activator	39,75	ETS-1	14,19	urokinase-type plasminogen activator	ETS-1	5328	2113	Gene	Gene	prognosis|amod|START_ENTITY correlated|nmod|prognosis correlated|nsubjpass|Expression Expression|nmod|END_ENTITY	Expression of ETS-1 is correlated with urokinase-type_plasminogen_activator and poor prognosis in pulmonary_adenocarcinoma .
15491342	0	urokinase-type_plasminogen_activator	35,71	Epidermal_growth_factor	0,23	urokinase-type plasminogen activator	Epidermal growth factor	5328	1950	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Epidermal_growth_factor stimulates urokinase-type_plasminogen_activator expression in human gingival fibroblasts .
10218628	0	urokinase-type_plasminogen_activator	41,77	Ets-1	0,5	urokinase-type plasminogen activator	Ets-1	5328	2113	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Ets-1 positively regulates expression of urokinase-type_plasminogen_activator -LRB- uPA -RRB- and invasiveness of astrocytic_tumors .
15042617	0	urokinase-type_plasminogen_activator	114,150	HGF	96,99	urokinase-type plasminogen activator	HGF	5328	3082	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	Enhanced invasion of hormone refractory_prostate_cancer cells through hepatocyte_growth_factor -LRB- HGF -RRB- induction of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
18202522	0	urokinase-type_plasminogen_activator	20,56	IL-1beta	0,8	urokinase-type plasminogen activator	IL-1beta	5328	3553	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	IL-1beta stimulates urokinase-type_plasminogen_activator expression and secretion in human dental pulp cells .
1953736	0	urokinase-type_plasminogen_activator	24,60	Oncostatin_M	0,12	urokinase-type plasminogen activator	Oncostatin M	5328	5008	Gene	Gene	activity|amod|START_ENTITY stimulates|dobj|activity stimulates|nsubj|END_ENTITY	Oncostatin_M stimulates urokinase-type_plasminogen_activator activity in human synovial fibroblasts .
14704150	0	urokinase-type_plasminogen_activator	47,83	Osteopontin	0,11	urokinase-type plasminogen activator	Osteopontin	5328	6696	Gene	Gene	secretion|nmod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Osteopontin induces AP-1-mediated secretion of urokinase-type_plasminogen_activator through c-Src-dependent epidermal_growth_factor_receptor transactivation in breast_cancer cells .
8635500	0	urokinase-type_plasminogen_activator	93,129	Plasminogen_activator_inhibitor_type-2	0,38	urokinase-type plasminogen activator	Plasminogen activator inhibitor type-2	5328	5055	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Plasminogen_activator_inhibitor_type-2 -LRB- PAI-2 -RRB- in human keratinocytes regulates pericellular urokinase-type_plasminogen_activator .
8847146	0	urokinase-type_plasminogen_activator	49,85	Prostate-specific_antigen	0,25	urokinase-type plasminogen activator	Prostate-specific antigen	5328	354	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Prostate-specific_antigen activates single-chain urokinase-type_plasminogen_activator .
10467419	0	urokinase-type_plasminogen_activator	83,119	RalA	0,4	urokinase-type plasminogen activator	RalA	18792(Tax:10090)	56044(Tax:10090)	Gene	Gene	requirement|nmod|START_ENTITY requirement|compound|END_ENTITY	RalA requirement for v-Src - and v-Ras-induced tumorigenicity and overproduction of urokinase-type_plasminogen_activator : involvement of metalloproteases .
1908092	0	urokinase-type_plasminogen_activator	43,79	Transforming_growth_factor_beta	0,31	urokinase-type plasminogen activator	Transforming growth factor beta	5328	7040	Gene	Gene	synthesis|compound|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Transforming_growth_factor_beta stimulates urokinase-type_plasminogen_activator and DNA synthesis , but not prostaglandin_E2 production , in human synovial fibroblasts .
1732009	0	urokinase-type_plasminogen_activator	52,88	Tumor_necrosis_factor	0,21	urokinase-type plasminogen activator	Tumor necrosis factor	5328	7124	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Tumor_necrosis_factor induction of endothelial cell urokinase-type_plasminogen_activator mediated proteolysis of extracellular matrix and its antagonism by gamma-interferon .
1801706	0	urokinase-type_plasminogen_activator	35,71	Tumor_necrosis_factor	0,21	urokinase-type plasminogen activator	Tumor necrosis factor	5328	7124	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Tumor_necrosis_factor induction of urokinase-type_plasminogen_activator in human endothelial cells .
2140060	0	urokinase-type_plasminogen_activator	48,84	Tumor_necrosis_factor	0,21	urokinase-type plasminogen activator	Tumor necrosis factor	5328	7124	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Tumor_necrosis_factor induces the production of urokinase-type_plasminogen_activator by human endothelial cells .
7860647	0	urokinase-type_plasminogen_activator	54,90	basic_fibroblast_growth_factor	126,156	urokinase-type plasminogen activator	basic fibroblast growth factor	281408(Tax:9913)	281161(Tax:9913)	Gene	Gene	expression|amod|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Transcriptional and posttranscriptional regulation of urokinase-type_plasminogen_activator expression in endothelial cells by basic_fibroblast_growth_factor .
8168613	0	urokinase-type_plasminogen_activator	38,74	c-fos	13,18	urokinase-type plasminogen activator	c-fos	5328	2353	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Induction of c-fos gene expression by urokinase-type_plasminogen_activator in human ovarian_cancer cells .
18616803	0	urokinase-type_plasminogen_activator	75,111	cathepsin_B	49,60	urokinase-type plasminogen activator	cathepsin B	5328	1508	Gene	Gene	activator|dep|START_ENTITY activator|compound|END_ENTITY	Tumor marker utility and prognostic relevance of cathepsin_B , cathepsin_L , urokinase-type_plasminogen_activator , plasminogen activator inhibitor type-1 , CEA and CA 19-9 in colorectal_cancer .
18714186	0	urokinase-type_plasminogen_activator	29,65	cathepsin_B	6,17	urokinase-type plasminogen activator	cathepsin B	5328	1508	Gene	Gene	levels|compound|START_ENTITY levels|compound|END_ENTITY	Serum cathepsin_B and plasma urokinase-type_plasminogen_activator levels in gastrointestinal_tract_cancers .
9180162	0	urokinase-type_plasminogen_activator	90,126	hK2	21,24	urokinase-type plasminogen activator	hK2	5328	58164	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Prostatic kallikrein hK2 , but not prostate-specific_antigen -LRB- hK3 -RRB- , activates single-chain urokinase-type_plasminogen_activator .
15042617	0	urokinase-type_plasminogen_activator	114,150	hepatocyte_growth_factor	70,94	urokinase-type plasminogen activator	hepatocyte growth factor	5328	3082	Gene	Gene	induction|nmod|START_ENTITY induction|amod|END_ENTITY	Enhanced invasion of hormone refractory_prostate_cancer cells through hepatocyte_growth_factor -LRB- HGF -RRB- induction of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- .
1384490	0	urokinase-type_plasminogen_activator	74,110	interleukin-1_alpha	29,48	urokinase-type plasminogen activator	interleukin-1 alpha	5328	3552	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Gamma-interferon counteracts interleukin-1_alpha stimulated expression of urokinase-type_plasminogen_activator in human endothelial cells in vitro .
17332916	0	urokinase-type_plasminogen_activator	58,94	interleukin-8	44,57	urokinase-type plasminogen activator	interleukin-8	5328	3576	Gene	Gene	pathway|amod|START_ENTITY pathway|dep|END_ENTITY	Cyclooxygenase-2 uses the protein_kinase_C / interleukin-8 / urokinase-type_plasminogen_activator pathway to increase the invasiveness of breast_cancer cells .
21199867	0	urokinase-type_plasminogen_activator	36,72	plasminogen_activator_inhibitor-1	76,109	urokinase-type plasminogen activator	plasminogen activator inhibitor-1	5328	5054	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Structural basis for recognition of urokinase-type_plasminogen_activator by plasminogen_activator_inhibitor-1 .
10996659	0	urokinase-type_plasminogen_activator	33,69	thrombin	73,81	urokinase-type plasminogen activator	thrombin	5328	2147	Gene	Gene	inactivation|nmod|START_ENTITY inactivation|nmod|END_ENTITY	The inactivation of single-chain urokinase-type_plasminogen_activator by thrombin on cultured human endothelial cells .
3114253	0	urokinase-type_plasminogen_activator	137,173	tissue-type_plasminogen_activator	73,106	urokinase-type plasminogen activator	tissue-type plasminogen activator	5328	5327	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a recombinant fusion protein of the finger domain of tissue-type_plasminogen_activator with a truncated single chain urokinase-type_plasminogen_activator .
3146822	0	urokinase-type_plasminogen_activator	213,249	tissue-type_plasminogen_activator	111,144	urokinase-type plasminogen activator	tissue-type plasminogen activator	5328	5327	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of a chimaeric plasminogen activator obtained by insertion of the second kringle structure of tissue-type_plasminogen_activator -LRB- amino_acids 173 through 262 -RRB- between residues Asp130 and Ser139 of urokinase-type_plasminogen_activator .
11983447	0	urokinase-type_plasminogen_activator	14,50	transforming_growth_factor_beta_1	89,122	urokinase-type plasminogen activator	transforming growth factor beta 1	18792(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Inhibition of urokinase-type_plasminogen_activator delays expression of c-jun , activated transforming_growth_factor_beta_1 , and matrix_metalloproteinase_2 during post-hepatectomy liver_regeneration in mice .
7683925	0	urokinase-type_plasminogen_activator	80,116	tumor_necrosis_factor	28,49	urokinase-type plasminogen activator	tumor necrosis factor	5328	7124	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|induction induction|compound|END_ENTITY	Role of protein_kinase_C in tumor_necrosis_factor induction of endothelial cell urokinase-type_plasminogen_activator .
1518351	0	urokinase-type_plasminogen_activator	12,48	u-PA	50,54	urokinase-type plasminogen activator	u-PA	102188193	102188193	Gene	Gene	Presence|nmod|START_ENTITY Presence|appos|END_ENTITY	Presence of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- in tissue extracts of antrochoanal_polyp .
1902597	0	urokinase-type_plasminogen_activator	41,77	u-PA	79,83	urokinase-type plasminogen activator	u-PA	5328	5328	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Physical exercise induces enhancement of urokinase-type_plasminogen_activator -LRB- u-PA -RRB- levels in plasma .
8849586	0	urokinase-type_plasminogen_activator	63,99	u-PA	101,105	urokinase-type plasminogen activator	u-PA	396985(Tax:9823)	396985(Tax:9823)	Gene	Gene	genes|amod|START_ENTITY genes|amod|END_ENTITY	Expression of transforming_growth_factor-beta1 -LRB- TGF-beta1 -RRB- and urokinase-type_plasminogen_activator -LRB- u-PA -RRB- genes during arterial repair in the pig .
12743986	0	urokinase-type_plasminogen_activator	24,60	uPA	62,65	urokinase-type plasminogen activator	uPA	5328	5328	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	A high cytosol value of urokinase-type_plasminogen_activator -LRB- uPA -RRB- may be predictive of early relapse in primary breast_cancer .
1526511	0	urokinase-type_plasminogen_activator	25,61	uPA	63,66	urokinase-type plasminogen activator	uPA	5328	5328	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of urokinase-type_plasminogen_activator -LRB- uPA -RRB- in invasive_cervical_cancer_of_the_uterus .
17098546	0	urokinase-type_plasminogen_activator	11,47	uPA	49,52	urokinase-type plasminogen activator	uPA	5328	5328	Gene	Gene	transfer|amod|START_ENTITY transfer|compound|END_ENTITY	Adenoviral urokinase-type_plasminogen_activator -LRB- uPA -RRB- gene transfer enhances venous thrombus resolution .
19701247	0	urokinase-type_plasminogen_activator	50,86	uPA	88,91	urokinase-type plasminogen activator	uPA	5328	5328	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Downregulation of miR-193b contributes to enhance urokinase-type_plasminogen_activator -LRB- uPA -RRB- expression and tumor progression and invasion in human breast_cancer .
19997513	0	urokinase-type_plasminogen_activator	17,53	uPA	55,58	urokinase-type plasminogen activator	uPA	5328	5328	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A pilot study of urokinase-type_plasminogen_activator -LRB- uPA -RRB- overexpression in the brush cytology of patients with malignant pancreatic_or_biliary_strictures .
8018952	0	urokinase-type_plasminogen_activator	37,73	uPA	75,78	urokinase-type plasminogen activator	uPA	5328	5328	Gene	Gene	assay|nmod|START_ENTITY assay|appos|END_ENTITY	Enzyme-linked immunosorbent assay of urokinase-type_plasminogen_activator -LRB- uPA -RRB- in cytosolic extracts of human breast_cancer tissue .
10339491	0	urokinase-type_plasminogen_activator	72,108	uPAR	149,153	urokinase-type plasminogen activator	uPAR	5328	5329	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Characterization of cell-associated plasminogen activation catalyzed by urokinase-type_plasminogen_activator , but independent of urokinase receptor -LRB- uPAR , CD87 -RRB- .
11437407	0	urokinase-type_plasminogen_activator	21,57	uPAR	68,72	urokinase-type plasminogen activator	uPAR	5328	5328	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Prognostic impact of urokinase-type_plasminogen_activator receptor -LRB- uPAR -RRB- in cytosols and pellet extracts derived from primary breast_tumours .
9165076	0	urokinase-type_plasminogen_activator	33,69	uPAR	95,99	urokinase-type plasminogen activator	uPAR	5328	5329	Gene	Gene	uPA|amod|START_ENTITY interaction|nmod|uPA Inhibition|nmod|interaction Inhibition|appos|END_ENTITY	Inhibition of the interaction of urokinase-type_plasminogen_activator -LRB- uPA -RRB- with its receptor -LRB- uPAR -RRB- by synthetic peptides .
16006865	0	urokinase-type_plasminogen_activator	14,50	urokinase-type_plasminogen_activator	52,88	urokinase-type plasminogen activator	urokinase-type plasminogen activator	5328	5328	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression of urokinase-type_plasminogen_activator , urokinase-type_plasminogen_activator receptor and plasminogen activator inhibitors in patients with renal_cell_carcinoma : correlation with tumor associated macrophage and prognosis .
16006865	0	urokinase-type_plasminogen_activator	52,88	urokinase-type_plasminogen_activator	14,50	urokinase-type plasminogen activator	urokinase-type plasminogen activator	5328	5328	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Expression of urokinase-type_plasminogen_activator , urokinase-type_plasminogen_activator receptor and plasminogen activator inhibitors in patients with renal_cell_carcinoma : correlation with tumor associated macrophage and prognosis .
22906080	0	urokinase-type_plasminogen_activator	127,163	urokinase-type_plasminogen_activator	90,126	urokinase-type plasminogen activator	urokinase-type plasminogen activator	5328	5328	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Aggregated low-density lipoprotein induce impairment of the cytoskeleton dynamics through urokinase-type_plasminogen_activator / urokinase-type_plasminogen_activator receptor in human vascular smooth muscle cell .
22906080	0	urokinase-type_plasminogen_activator	90,126	urokinase-type_plasminogen_activator	127,163	urokinase-type plasminogen activator	urokinase-type plasminogen activator	5328	5328	Gene	Gene	receptor|amod|START_ENTITY receptor|compound|END_ENTITY	Aggregated low-density lipoprotein induce impairment of the cytoskeleton dynamics through urokinase-type_plasminogen_activator / urokinase-type_plasminogen_activator receptor in human vascular smooth muscle cell .
23190581	0	urokinase-type_plasminogen_activator	36,72	urokinase-type_plasminogen_activator	74,110	urokinase-type plasminogen activator	urokinase-type plasminogen activator	5328	5328	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Immunohistochemical localization of urokinase-type_plasminogen_activator , urokinase-type_plasminogen_activator receptor and a2-antiplasmin in human corneal perforation : a case report .
23190581	0	urokinase-type_plasminogen_activator	74,110	urokinase-type_plasminogen_activator	36,72	urokinase-type plasminogen activator	urokinase-type plasminogen activator	5328	5328	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Immunohistochemical localization of urokinase-type_plasminogen_activator , urokinase-type_plasminogen_activator receptor and a2-antiplasmin in human corneal perforation : a case report .
10417621	0	urokinase-type_plasminogen_activator_receptor	14,59	uPAR	61,65	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	UVB increases urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- expression .
12665524	0	urokinase-type_plasminogen_activator_receptor	11,56	uPAR	58,62	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- to the mannose_6-phosphate / insulin-like growth factor II receptor : contrasting interactions of full-length and soluble forms of uPAR .
15543615	0	urokinase-type_plasminogen_activator_receptor	44,89	uPAR	91,95	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Real-time quantitative PCR determination of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- expression of isolated micrometastatic cells from bone marrow of breast_cancer patients .
15894933	0	urokinase-type_plasminogen_activator_receptor	14,59	uPAR	61,65	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- in primary central_nervous_system_neoplasms .
18189329	0	urokinase-type_plasminogen_activator_receptor	133,178	uPAR	180,184	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Endothelial cells and normal breast epithelial cells enhance invasion of breast_carcinoma cells by CXCR-4-dependent up-regulation of urokinase-type_plasminogen_activator_receptor -LRB- uPAR , CD87 -RRB- expression .
19435784	0	urokinase-type_plasminogen_activator_receptor	21,66	uPAR	68,72	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Amplification of the urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- gene in ductal pancreatic_carcinomas identifies a clinically high-risk group .
23852693	0	urokinase-type_plasminogen_activator_receptor	16,61	uPAR	63,67	urokinase-type plasminogen activator receptor	uPAR	18793(Tax:10090)	18793(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Inactivation of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- gene induces dermal and pulmonary_fibrosis_and_peripheral_microvasculopathy in mice : a new model of experimental scleroderma ?
24474395	0	urokinase-type_plasminogen_activator_receptor	25,70	uPAR	72,76	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A retrospective study of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- as a prognostic factor in cancer_of_the_uterine_cervix .
9846056	0	urokinase-type_plasminogen_activator_receptor	35,80	uPAR	82,86	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and localization of the urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- in the human placenta .
9869396	0	urokinase-type_plasminogen_activator_receptor	22,67	uPAR	69,73	urokinase-type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Stromal expression of urokinase-type_plasminogen_activator_receptor -LRB- uPAR -RRB- is associated with invasive_growth in primary_liver_cancer .
14973118	0	urokinase_plasminogen_activator	48,79	Beta-catenin	0,12	urokinase plasminogen activator	Beta-catenin	5328	1499	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Beta-catenin up-regulates the expression of the urokinase_plasminogen_activator in human colorectal_tumors .
22797075	0	urokinase_plasminogen_activator	61,92	CFTR	0,4	urokinase plasminogen activator	CFTR	5328	1080	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	CFTR suppresses tumor progression through miR-193b targeting urokinase_plasminogen_activator -LRB- uPA -RRB- in prostate_cancer .
10457348	0	urokinase_plasminogen_activator	14,45	E-cadherin	64,74	urokinase plasminogen activator	E-cadherin	5328	999	Gene	Gene	activity|amod|START_ENTITY activity|nmod|END_ENTITY	Regulation of urokinase_plasminogen_activator -LRB- uPA -RRB- activity by E-cadherin and hormones in mammary epithelial cells .
18988861	0	urokinase_plasminogen_activator	42,73	PLAU	80,84	urokinase plasminogen activator	PLAU	5328	5328	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Quebec_platelet_disorder is linked to the urokinase_plasminogen_activator gene -LRB- PLAU -RRB- and increases expression of the linked allele in megakaryocytes .
15988036	0	urokinase_plasminogen_activator	49,80	Platelet-derived_growth_factor_D	0,32	urokinase plasminogen activator	Platelet-derived growth factor D	5328	80310	Gene	Gene	activated|nmod|START_ENTITY activated|nsubjpass|END_ENTITY	Platelet-derived_growth_factor_D is activated by urokinase_plasminogen_activator in prostate_carcinoma cells .
10524682	0	urokinase_plasminogen_activator	23,54	insulin-like_growth_factor_1	58,86	urokinase plasminogen activator	insulin-like growth factor 1	5328	3479	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Abnormal regulation of urokinase_plasminogen_activator by insulin-like_growth_factor_1 in human osteoarthritic_subchondral_osteoblasts .
9746723	0	urokinase_plasminogen_activator	50,81	plasminogen_activator_inhibitor_1	82,115	urokinase plasminogen activator	plasminogen activator inhibitor 1	5328	5054	Gene	Gene	START_ENTITY|dep|complex complex|amod|END_ENTITY	Human endothelial cell migration is stimulated by urokinase_plasminogen_activator : plasminogen_activator_inhibitor_1 complex released from endometrial stromal cells stimulated with transforming_growth_factor_beta1 ; possible mechanism for paracrine stimulation of endometrial angiogenesis .
10457348	0	urokinase_plasminogen_activator	14,45	uPA	47,50	urokinase plasminogen activator	uPA	5328	5328	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	Regulation of urokinase_plasminogen_activator -LRB- uPA -RRB- activity by E-cadherin and hormones in mammary epithelial cells .
22013113	0	urokinase_plasminogen_activator	73,104	uPA	111,114	urokinase plasminogen activator	uPA	5328	5328	Gene	Gene	START_ENTITY|dep|activation activation|compound|END_ENTITY	Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase_plasminogen_activator -LRB- uPA -RRB- / uPA receptor-dependent activation of TGF-b and potentiates fibrosis .
9560322	0	urokinase_plasminogen_activator	52,83	uPA	85,88	urokinase plasminogen activator	uPA	18792(Tax:10090)	18792(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Synergistic transcriptional activation of the mouse urokinase_plasminogen_activator -LRB- uPA -RRB- gene and of its enhancer activator_protein_1 -LRB- AP1 -RRB- site by cAMP and retinoic_acid .
11204271	0	urokinase_plasminogen_activator	60,91	urokinase_plasminogen_activator	92,123	urokinase plasminogen activator	urokinase plasminogen activator	5328	5328	Gene	Gene	system|amod|START_ENTITY system|compound|END_ENTITY	Cell invasion is affected by differential expression of the urokinase_plasminogen_activator / urokinase_plasminogen_activator receptor system in muscle satellite cells from normal and dystrophic patients .
11204271	0	urokinase_plasminogen_activator	92,123	urokinase_plasminogen_activator	60,91	urokinase plasminogen activator	urokinase plasminogen activator	5328	5328	Gene	Gene	system|compound|START_ENTITY system|amod|END_ENTITY	Cell invasion is affected by differential expression of the urokinase_plasminogen_activator / urokinase_plasminogen_activator receptor system in muscle satellite cells from normal and dystrophic patients .
21638078	0	urokinase_plasminogen_activator_receptor	8,48	CD87	50,54	urokinase plasminogen activator receptor	CD87	5329	5329	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of urokinase_plasminogen_activator_receptor -LRB- CD87 -RRB- as a prognostic marker in acute_myeloid_leukemia .
19903858	0	urokinase_plasminogen_activator_receptor	70,110	MMP-2	131,136	urokinase plasminogen activator receptor	MMP-2	5329	4313	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase_plasminogen_activator_receptor signaling-dependent MMP-2 activation .
15172186	0	urokinase_plasminogen_activator_receptor	62,102	Thrombospondin-1	0,16	urokinase plasminogen activator receptor	Thrombospondin-1	5329	7057	Gene	Gene	up-regulates|nmod|START_ENTITY up-regulates|nsubj|END_ENTITY	Thrombospondin-1 up-regulates tumor cell invasion through the urokinase_plasminogen_activator_receptor in head_and_neck cancer cells .
14660675	0	urokinase_plasminogen_activator_receptor	19,59	bcl-2	0,5	urokinase plasminogen activator receptor	bcl-2	5329	596	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	bcl-2 induction of urokinase_plasminogen_activator_receptor expression in human cancer cells through Sp1 activation : involvement of ERK1/ERK2 activity .
10917542	0	urokinase_plasminogen_activator_receptor	85,125	thrombospondin-1	12,28	urokinase plasminogen activator receptor	thrombospondin-1	5329	7057	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Tumour cell thrombospondin-1 regulates tumour cell adhesion and invasion through the urokinase_plasminogen_activator_receptor .
11313929	0	urokinase_plasminogen_activator_receptor	53,93	uPAR	95,99	urokinase plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The small-GTPase RalA activates transcription of the urokinase_plasminogen_activator_receptor -LRB- uPAR -RRB- gene via an AP1-dependent mechanism .
16756681	0	urokinase_receptor	40,58	uPAR	60,64	urokinase receptor	uPAR	5329	5329	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The superoxide scavenger TEMPOL induces urokinase_receptor -LRB- uPAR -RRB- expression in human prostate_cancer cells .
7528215	0	urokinase_receptor	22,40	vitronectin	69,80	urokinase receptor	vitronectin	5329	7448	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the urokinase_receptor as an adhesion receptor for vitronectin .
16893520	0	urokinase_type_plasminogen_activator_receptor	34,79	uPAR	81,85	urokinase type plasminogen activator receptor	uPAR	5329	5329	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Aspirin upregulates expression of urokinase_type_plasminogen_activator_receptor -LRB- uPAR -RRB- gene in human colon_cancer cells through AP1 .
8382593	0	uromodulin	30,40	UMOD	47,51	uromodulin	UMOD	7369	7369	Gene	Gene	gene|compound|START_ENTITY assignment|nmod|gene assignment|appos|END_ENTITY	Chromosomal assignment of the uromodulin gene -LRB- UMOD -RRB- to 16p13 .11 .
18535602	0	uromodulin-like_1	58,75	UMODL1	77,83	uromodulin-like 1	UMODL1	89766	89766	Gene	Gene	region|amod|START_ENTITY region|appos|END_ENTITY	New susceptibility locus for high_myopia is linked to the uromodulin-like_1 -LRB- UMODL1 -RRB- gene region on chromosome 21q22 .3 .
2037278	0	uroporphyrinogen_III_synthase	33,62	UROS	64,68	uroporphyrinogen III synthase	UROS	7390	7390	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Regional assignment of the human uroporphyrinogen_III_synthase -LRB- UROS -RRB- gene to chromosome 10q25 .2 -- q26 .3 .
23275732	0	uroporphyrinogen_III_synthase	25,54	UROS	56,60	uroporphyrinogen III synthase	UROS	7390	7390	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Phylogenetic analysis of uroporphyrinogen_III_synthase -LRB- UROS -RRB- gene .
11929044	0	uroporphyrinogen_decarboxylase	10,40	URO-D	42,47	uroporphyrinogen decarboxylase	URO-D	7389	7389	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of uroporphyrinogen_decarboxylase -LRB- URO-D -RRB- in erythrocytes of Italian porphyria cutanea tarda patients .
11295834	0	uroporphyrinogen_decarboxylase	35,65	UROD	67,71	uroporphyrinogen decarboxylase	UROD	7389	7389	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Seven novel point mutations in the uroporphyrinogen_decarboxylase -LRB- UROD -RRB- gene in patients with familial_porphyria_cutanea_tarda -LRB- f-PCT -RRB- .
16026339	0	uroporphyrinogen_decarboxylase	42,72	UROD	74,78	uroporphyrinogen decarboxylase	UROD	100514239	100514239	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of a mutation in the ovine uroporphyrinogen_decarboxylase -LRB- UROD -RRB- gene associated with a type of porphyria .
21965295	0	urotensin-II	80,92	FoxO3a	28,34	urotensin-II	FoxO3a	24111(Tax:10090)	56484(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|dobj|activation activation|nmod|END_ENTITY	NOX4 mediates activation of FoxO3a and matrix_metalloproteinase-2 expression by urotensin-II .
22399808	0	urotensin-II	56,68	NOX2	21,25	urotensin-II	NOX2	24111(Tax:10090)	13058(Tax:10090)	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II .
21965295	0	urotensin-II	80,92	NOX4	0,4	urotensin-II	NOX4	24111(Tax:10090)	50490(Tax:10090)	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	NOX4 mediates activation of FoxO3a and matrix_metalloproteinase-2 expression by urotensin-II .
23333481	0	urotensin-II	61,73	UTS-II	75,81	urotensin-II	UTS-II	10911	10911	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Thr21Met -LRB- T21M -RRB- but not Ser89Asn -LRB- S89N -RRB- polymorphisms of the urotensin-II -LRB- UTS-II -RRB- gene are associated with Behcet 's _ disease -LRB- BD -RRB- .
22587369	0	urotensin-II	63,75	UTS2	77,81	urotensin-II	UTS2	10911	10911	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between Thr21Met and Ser89Asn polymorphisms of the urotensin-II -LRB- UTS2 -RRB- gene , diabetes_mellitus , and diabetic_retinopathy .
10581185	0	urotensin_II	18,30	GPR14	98,103	urotensin II	GPR14	10911	2837	Gene	Gene	Identification|nmod|START_ENTITY ligand|nsubj|Identification ligand|nmod|END_ENTITY	Identification of urotensin_II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14 .
12495432	0	urotensin_II	23,35	GPR14	36,41	urotensin II	GPR14	29180(Tax:10116)	57305(Tax:10116)	Gene	Gene	Photolabelling|dobj|START_ENTITY receptor|dep|Photolabelling receptor|nummod|END_ENTITY	Photolabelling the rat urotensin_II / GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain .
15273242	0	urotensin_II	66,78	GPR14	25,30	urotensin II	GPR14	29180(Tax:10116)	57305(Tax:10116)	Gene	Gene	distribution|nmod|START_ENTITY distribution|nmod|END_ENTITY	Cellular distribution of GPR14 and the positive inotropic role of urotensin_II in the myocardium in adult rat .
15306183	0	urotensin_II	24,36	GPR14	62,67	urotensin II	GPR14	10911	2837	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Increased expression of urotensin_II and its cognate receptor GPR14 in atherosclerotic_lesions of the human aorta .
21559414	0	urotensin_II	24,36	UTS2	43,47	urotensin II	UTS2	10911	10911	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association analysis of urotensin_II gene -LRB- UTS2 -RRB- and flanking regions with biochemical parameters related to insulin resistance .
16266462	0	urotensin_II	11,23	adrenomedullin	40,54	urotensin II	adrenomedullin	10911	133	Gene	Gene	START_ENTITY|nmod|secretion secretion|nmod|END_ENTITY	-LSB- Effect of urotensin_II on secretion of adrenomedullin from human vascular endothelial cells -RSB- .
15525466	0	urotensin_II	15,27	eNOS	60,64	urotensin II	eNOS	29180(Tax:10116)	24600(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY END_ENTITY|nsubj|Effects	Effects of rat urotensin_II on coronary_flow and myocardial eNOS protein expression in isolated rat heart .
22319601	0	urotensin_II	11,23	eNOS	72,76	urotensin II	eNOS	10911	4846	Gene	Gene	modulates|nsubj|START_ENTITY modulates|nmod|END_ENTITY	Endogenous urotensin_II selectively modulates erectile function through eNOS .
21158070	0	urotensin_II	11,23	iNOS	27,31	urotensin II	iNOS	10911	4843	Gene	Gene	START_ENTITY|nmod|expression expression|amod|END_ENTITY	-LSB- Effect of urotensin_II on iNOS expression in human umbilical vein endothelial cells -RSB- .
20878108	0	urotensin_II	102,114	urotensin_II	14,26	urotensin II	urotensin II	10911	10911	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of urotensin_II and its receptor in human lung_adenocarcinoma A549 cells and the effect of urotensin_II on lung_adenocarcinoma growth in vitro and in vivo .
20878108	0	urotensin_II	14,26	urotensin_II	102,114	urotensin II	urotensin II	10911	10911	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of urotensin_II and its receptor in human lung_adenocarcinoma A549 cells and the effect of urotensin_II on lung_adenocarcinoma growth in vitro and in vivo .
22433941	0	urotensin_II-related_peptide	45,73	URP	75,78	urotensin II-related peptide	URP	100001008(Tax:7955)	100001008(Tax:7955)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization of the true ortholog of the urotensin_II-related_peptide -LRB- URP -RRB- gene in teleosts .
17389776	0	uterine_sensitization-associated_gene-1	14,53	USAG-1	55,61	uterine sensitization-associated gene-1	USAG-1	66042(Tax:10090)	66042(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of uterine_sensitization-associated_gene-1 -LRB- USAG-1 -RRB- in the mouse uterus during the peri-implantation period .
7587387	0	uteroferrin	18,29	ACP5	36,40	uteroferrin	ACP5	397414(Tax:9823)	397414(Tax:9823)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Assignment of the uteroferrin gene -LRB- ACP5 -RRB- to swine chromosome 2q12 -- > q21 by fluorescence in situ hybridization .
21170691	0	uteroglobin-related_protein_1	74,103	UGRP1	105,110	uteroglobin-related protein 1	UGRP1	117156	117156	Gene	Gene	increases|amod|START_ENTITY increases|appos|END_ENTITY	The -112 G > A polymorphism of the secretoglobin_3A2 -LRB- SCGB3A2 -RRB- gene encoding uteroglobin-related_protein_1 -LRB- UGRP1 -RRB- increases risk for the development of Graves ' _ disease in subsets of patients with elevated levels of immunoglobulin_E .
15811345	0	uteroglobin-related_protein_2	13,42	EGF_and_TGFalpha	65,81	uteroglobin-related protein 2	EGF and TGFalpha	68662(Tax:10090)	13645(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- expression by EGF_and_TGFalpha .
16237061	0	uteroglobin-related_protein_2	13,42	Th2	74,77	uteroglobin-related protein 2	Th2	68662(Tax:10090)	15111(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- gene expression by the Th2 cytokines IL-4 and IL-13 .
15811345	0	uteroglobin-related_protein_2	13,42	Ugrp2	44,49	uteroglobin-related protein 2	Ugrp2	68662(Tax:10090)	68662(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Induction of uteroglobin-related_protein_2 -LRB- Ugrp2 -RRB- expression by EGF_and_TGFalpha .
8012192	0	utrophin	87,95	50_kDa_dystrophin-associated_glycoprotein	18,59	utrophin	50 kDa dystrophin-associated glycoprotein	7402	6442	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Deficiency of the 50_kDa_dystrophin-associated_glycoprotein and abnormal expression of utrophin in two south Asian cousins with variable expression of severe childhood autosomal_recessive_muscular_dystrophy .
8186702	0	utrophin	43,51	Dystrophin	0,10	utrophin	Dystrophin	7402	1756	Gene	Gene	protein|appos|START_ENTITY protein|amod|END_ENTITY	Dystrophin and dystrophin-related protein -LRB- utrophin -RRB- distribution in normal and dystrophin-deficient_skeletal_muscles .
9447606	0	utrophin	26,34	Dystrophin	0,10	utrophin	Dystrophin	398351(Tax:8355)	100355731(Tax:9986)	Gene	Gene	replaced|nmod|START_ENTITY replaced|nsubjpass|END_ENTITY	Dystrophin is replaced by utrophin in frog heart ; implications for muscular_dystrophy .
15963030	0	utrophin	26,34	RhoA	11,15	utrophin	RhoA	22288(Tax:10090)	11848(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	The GTPase RhoA increases utrophin expression and stability , as well as its localization at the plasma membrane .
19409875	0	utrophin	50,58	RhoA	0,4	utrophin	RhoA	22288(Tax:10090)	11848(Tax:10090)	Gene	Gene	up-regulation|nmod|START_ENTITY leads|nmod|up-regulation leads|nsubj|END_ENTITY	RhoA leads to up-regulation and relocalization of utrophin in muscle fibers .
10369873	0	utrophin	41,49	dystrophin	88,98	utrophin	dystrophin	7402	1756	Gene	Gene	transcripts|nmod|START_ENTITY transcripts|acl:relcl|homologues homologues|nmod|forms forms|nmod|END_ENTITY	Up71 and up140 , two novel transcripts of utrophin that are homologues of short forms of dystrophin .
10423348	0	utrophin	6,14	dystrophin	54,64	utrophin	dystrophin	7402	1756	Gene	Gene	rescue|nsubj|START_ENTITY rescue|nmod|mutations mutations|amod|END_ENTITY	Could utrophin rescue the myocardium of patients with dystrophin gene mutations ?
11223239	0	utrophin	17,25	dystrophin	4,14	utrophin	dystrophin	7402	42327(Tax:7227)	Gene	Gene	homologues|nsubj|START_ENTITY END_ENTITY|parataxis|homologues	The dystrophin / utrophin homologues in Drosophila and in sea urchin .
8300622	0	utrophin	15,23	dystrophin	37,47	utrophin	dystrophin	7402	1756	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of utrophin and multiple dystrophin short forms with the mammalian M -LRB- r -RRB- 58,000 dystrophin-associated protein -LRB- syntrophin -RRB- .
8557116	0	utrophin	45,53	dystrophin	27,37	utrophin	dystrophin	100351667(Tax:9986)	100355731(Tax:9986)	Gene	Gene	products|compound|START_ENTITY and/or|dobj|products and/or|nsubj|Presence Presence|nmod|END_ENTITY	Presence of long and short dystrophin and/or utrophin products in Torpedo marmorata peripheral nerves .
10077665	0	utrophin	13,21	heregulin	41,50	utrophin	heregulin	7402	211323(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Induction of utrophin gene expression by heregulin in skeletal muscle cells : role of the N-box motif and GA binding protein .
1918074	0	uvomorulin	43,53	E-cadherin	55,65	uvomorulin	E-cadherin	999	999	Gene	Gene	Biosynthesis|nmod|START_ENTITY Biosynthesis|appos|END_ENTITY	Biosynthesis of the cell adhesion molecule uvomorulin -LRB- E-cadherin -RRB- in Madin-Darby canine kidney epithelial cells .
8144691	0	uvomorulin	44,54	E-cadherin	32,42	uvomorulin	E-cadherin	12550(Tax:10090)	12550(Tax:10090)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of recombinant E-cadherin -LRB- uvomorulin -RRB- expressed in insect cells .
26092939	0	v-ATPase	34,42	Mitf	0,4	v-ATPase	Mitf	40679(Tax:7227)	3885647(Tax:7227)	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	Mitf is a master regulator of the v-ATPase forming an Mitf/v-ATPase/TORC1 control module for cellular homeostasis .
18403249	0	v-Abl	42,47	c-Cbl	0,5	v-Abl	c-Cbl	25	867	Gene	Gene	effects|nmod|START_ENTITY effects|amod|END_ENTITY	c-Cbl facilitates cytoskeletal effects in v-Abl transformed fibroblast through Rac1 - and Rap1-mediated signaling .
8524218	0	v-Abl	0,5	c-myc	16,21	v-Abl	c-myc	25	4609	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|amod|END_ENTITY	v-Abl activates c-myc transcription through the E2F site .
1408148	0	v-Raf	50,55	Egr-1	32,37	v-Raf	Egr-1	110157(Tax:10090)	13653(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|promoter promoter|compound|END_ENTITY	Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements .
7739532	0	v-myb	58,63	Retinoic_acid_receptor_alpha	0,28	v-myb	Retinoic acid receptor alpha	4602	5914	Gene	Gene	suppresses|nmod|START_ENTITY suppresses|nsubj|END_ENTITY	Retinoic_acid_receptor_alpha suppresses transformation by v-myb .
17403668	0	vCCL2	111,116	lymphotactin_receptor	51,72	vCCL2	lymphotactin receptor	4961514(Tax:37296)	2829	Gene	Gene	targets|nmod|START_ENTITY targets|dobj|END_ENTITY	Kaposi_sarcoma-associated_herpes_virus targets the lymphotactin_receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3 .
12776188	0	vFLIP	48,53	IL-6	71,75	vFLIP	IL-6	4961494(Tax:37296)	3569	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus encoded vFLIP induces cellular IL-6 expression : the role of the NF-kappaB and JNK/AP1 pathways .
16809323	0	vFLIP	38,43	NF-kappaB	14,23	vFLIP	NF-kappaB	4961494(Tax:37296)	4790	Gene	Gene	gene|compound|START_ENTITY END_ENTITY|nmod|gene	Activation of NF-kappaB by the latent vFLIP gene of Kaposi 's _ sarcoma-associated_herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype .
15231571	0	vGPCR	70,75	Rac1	17,21	vGPCR	Rac1	4961465(Tax:37296)	5879	Gene	Gene	links|dobj|START_ENTITY links|nsubj|END_ENTITY	The small GTPase Rac1 links the Kaposi_sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia .
26053743	0	vGluT2	49,55	Vesicular_Glutamate_Transporter_2	14,47	vGluT2	Vesicular Glutamate Transporter 2	84487(Tax:10116)	84487(Tax:10116)	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of Vesicular_Glutamate_Transporter_2 -LRB- vGluT2 -RRB- on Large Dense-Core Vesicles within GnRH Neuroterminals of Aging Female Rats .
21618220	0	vGluT2	71,77	vesicular_glutamate_transporter_2	36,69	vGluT2	vesicular glutamate transporter 2	102093241	102093241	Gene	Gene	localization|appos|START_ENTITY localization|nmod|END_ENTITY	Immunohistochemical localization of vesicular_glutamate_transporter_2 -LRB- vGluT2 -RRB- in the central nervous system of the pigeon -LRB- Columba_livia -RRB- .
8622679	0	vHNF1	27,32	COUP-TF1	66,74	vHNF1	COUP-TF1	6928	7025	Gene	Gene	promoter|amod|START_ENTITY regulation|nmod|promoter regulation|nmod|END_ENTITY	Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1 / Ear3 and COUP-TFII/Arp1 .
12065843	0	vIII	31,35	epidermal_growth_factor_receptor	54,86	vIII	epidermal growth factor receptor	1351	1956	Gene	Gene	mutation|amod|START_ENTITY mutation|nmod|END_ENTITY	A new antibody recognizing the vIII mutation of human epidermal_growth_factor_receptor .
14668346	0	vIRF-3	48,54	IRF-3	107,112	vIRF-3	IRF-3	4961493(Tax:37296)	3661	Gene	Gene	stimulates|nsubj|START_ENTITY stimulates|dobj|activity activity|nmod|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus-encoded vIRF-3 stimulates the transcriptional activity of cellular IRF-3 and IRF-7 .
11358512	0	vMIP-II	59,66	CCR2	0,4	vMIP-II	CCR2	4961514(Tax:37296)	729230	Gene	Gene	properties|nmod|START_ENTITY properties|nummod|END_ENTITY	CCR2 and CCR5 receptor-binding properties of herpesvirus-8 vMIP-II based on sequence analysis and its solution structure .
20682599	0	vWF	31,34	FVIII	98,103	vWF	FVIII	7450	2157	Gene	Gene	genes|compound|START_ENTITY Polymorphisms|nmod|genes Polymorphisms|nmod|levels levels|nmod|END_ENTITY	Polymorphisms and mutations in vWF and ADAMTS13 genes and their correlation with plasma levels of FVIII and vWF in patients with deep_venous_thrombosis .
2104761	0	vWF	29,32	FVIII	72,77	vWF	FVIII	7450	2157	Gene	Gene	_|appos|START_ENTITY _|nsubj|_ _|dobj|defect defect|nmod|deficiency deficiency|amod|patient patient|nmod|factor_VIII factor_VIII|appos|END_ENTITY	A new von_Willebrand_factor _ -LRB- vWF -RRB- _ defect in a patient with factor_VIII -LRB- FVIII -RRB- deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF .
11916084	0	vWF	116,119	Proline-rich_tyrosine_kinase_2	0,30	vWF	Proline-rich tyrosine kinase 2	7450	2185	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Proline-rich_tyrosine_kinase_2 and focal_adhesion_kinase are involved in different phases of platelet activation by vWF .
17273877	0	vWF	63,66	von_Willebrand_factor	40,61	vWF	von Willebrand factor	7450	7450	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Complex variability of intron 40 of the von_Willebrand_factor -LRB- vWF -RRB- gene .
23223570	0	vaccinia-related_kinase_1	105,130	Mitogen-activated_protein_kinase_phosphatase_2	0,46	vaccinia-related kinase 1	Mitogen-activated protein kinase phosphatase 2	7443	1846	Gene	Gene	regulates|advcl|START_ENTITY regulates|nsubj|END_ENTITY	Mitogen-activated_protein_kinase_phosphatase_2 regulates histone H3 phosphorylation via interaction with vaccinia-related_kinase_1 .
15378002	0	vaccinia-related_kinase_1	35,60	c-Jun	0,5	vaccinia-related kinase 1	c-Jun	7443	3725	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	c-Jun phosphorylation by the human vaccinia-related_kinase_1 -LRB- VRK1 -RRB- and its cooperation with the N-terminal_kinase_of_c-Jun -LRB- JNK -RRB- .
24077878	0	vacuolar_protein_sorting_4B	26,53	VPS4B	55,60	vacuolar protein sorting 4B	VPS4B	360834(Tax:10116)	360834(Tax:10116)	Gene	Gene	changes|nmod|START_ENTITY changes|appos|END_ENTITY	The expression changes of vacuolar_protein_sorting_4B -LRB- VPS4B -RRB- following middle_cerebral_artery_occlusion -LRB- MCAO -RRB- in adult rats brain hippocampus .
15367889	0	vacuole_membrane_protein_1	14,40	VMP1	42,46	vacuole membrane protein 1	VMP1	192129(Tax:10116)	192129(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vacuole_membrane_protein_1 -LRB- VMP1 -RRB- in spontaneous chronic_pancreatitis in the WBN/Kob rat .
22854957	0	vacuole_protein_sorting_18	12,38	Vps18	40,45	vacuole protein sorting 18	Vps18	228545(Tax:10090)	228545(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Ablation of vacuole_protein_sorting_18 -LRB- Vps18 -RRB- gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes .
23293021	0	valosin-containing_protein	47,73	Fas-associated_factor_1	11,34	valosin-containing protein	Fas-associated factor 1	7415	11124	Gene	Gene	proteins|amod|START_ENTITY END_ENTITY|nmod|proteins	Complex of Fas-associated_factor_1 -LRB- FAF1 -RRB- with valosin-containing_protein -LRB- VCP -RRB- - Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation -LRB- ERAD -RRB- .
20833645	0	valosin-containing_protein	23,49	Strumpellin	0,11	valosin-containing protein	Strumpellin	7415	9897	Gene	Gene	partner|amod|START_ENTITY partner|nsubj|END_ENTITY	Strumpellin is a novel valosin-containing_protein binding partner linking hereditary_spastic_paraplegia to protein_aggregation_diseases .
23293021	0	valosin-containing_protein	47,73	VCP	75,78	valosin-containing protein	VCP	7415	7415	Gene	Gene	proteins|amod|START_ENTITY proteins|appos|END_ENTITY	Complex of Fas-associated_factor_1 -LRB- FAF1 -RRB- with valosin-containing_protein -LRB- VCP -RRB- - Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation -LRB- ERAD -RRB- .
14761919	0	valosin-containing_protein	24,50	p97	52,55	valosin-containing protein	p97	7415	7415	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of valosin-containing_protein -LRB- p97 -RRB- is associated with lymph node metastasis and prognosis of pancreatic_ductal_adenocarcinoma .
15131036	0	valosin-containing_protein	23,49	p97	51,54	valosin-containing protein	p97	7415	7415	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elevated expression of valosin-containing_protein -LRB- p97 -RRB- is associated with poor prognosis of prostate_cancer .
16189643	0	valosin-containing_protein	24,50	p97	52,55	valosin-containing protein	p97	7415	7415	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of valosin-containing_protein -LRB- p97 -RRB- is correlated with disease recurrence in follicular_thyroid_cancer .
17584300	0	valosin-containing_protein	15,41	p97	48,51	valosin-containing protein	p97	7415	7415	Gene	Gene	Involvement|nmod|START_ENTITY Involvement|dep|END_ENTITY	Involvement of valosin-containing_protein -LRB- VCP -RRB- / p97 in the formation and clearance of abnormal protein aggregates .
9988688	0	valyl-tRNA_synthetase	36,57	EF-1alpha	81,90	valyl-tRNA synthetase	EF-1alpha	7407	1917	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Functional interaction of mammalian valyl-tRNA_synthetase with elongation factor EF-1alpha in the complex with EF-1H .
12926020	0	vanilloid_receptor	20,38	VR1	40,43	vanilloid receptor	VR1	7442	7442	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of the vanilloid_receptor -LRB- VR1 -RRB- in the gastrointestinal tract .
15857679	0	vanilloid_receptor_1	31,51	TRPV1	53,58	vanilloid receptor 1	TRPV1	83810(Tax:10116)	83810(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression and distribution of vanilloid_receptor_1 -LRB- TRPV1 -RRB- in the adult rat brain .
14514756	0	vanilloid_receptor_1	14,34	VR1	36,39	vanilloid receptor 1	VR1	7442	7442	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of vanilloid_receptor_1 -LRB- VR1 -RRB- by eugenol .
24751833	0	vanin-1	35,42	PPAR-alpha	0,10	vanin-1	PPAR-alpha	22361(Tax:10090)	19013(Tax:10090)	Gene	Gene	regulation|nmod|START_ENTITY regulation|amod|END_ENTITY	PPAR-alpha dependent regulation of vanin-1 mediates hepatic lipid metabolism .
14588248	0	vasa	26,30	Fat_facets	0,10	vasa	Fat facets	26067080	43749(Tax:7227)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Fat_facets interacts with vasa in the Drosophila pole plasm and protects it from degradation .
10719731	0	vascular-endothelial-growth-factor	8,42	VEGF	44,48	vascular-endothelial-growth-factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	p53 and vascular-endothelial-growth-factor -LRB- VEGF -RRB- expression predicts outcome in 833 patients with primary breast_carcinoma .
9839166	0	vascular-endothelial_cadherin	33,62	epithelial_cadherin	75,94	vascular-endothelial cadherin	epithelial cadherin	1003	999	Gene	Gene	presence|nmod|START_ENTITY presence|nmod|END_ENTITY	Epithelioid_sarcoma : presence of vascular-endothelial_cadherin and lack of epithelial_cadherin .
21556619	0	vascular-permeability_factor	28,56	vpf	58,61	vascular-permeability factor	vpf	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	The selective-inhibition of vascular-permeability_factor -LRB- vpf -RRB- expression in ovarian-carcinoma cell-lines by gonadotropin-releasing-hormone -LRB- GnRH -RRB- agonist .
12493764	0	vascular_adhesion_molecule-1	24,52	Thrombin	0,8	vascular adhesion molecule-1	Thrombin	7412	2147	Gene	Gene	stimulation|nmod|START_ENTITY stimulation|compound|END_ENTITY	Thrombin stimulation of vascular_adhesion_molecule-1 in endothelial cells is mediated by protein_kinase_C _ -LRB- PKC -RRB- - delta-NF-kappa B and PKC-zeta-GATA signaling pathways .
19861682	0	vascular_adhesion_protein-1	28,55	Siglec-10	6,15	vascular adhesion protein-1	Siglec-10	8639	89790	Gene	Gene	bind|nmod|START_ENTITY bind|nsubj|END_ENTITY	Human Siglec-10 can bind to vascular_adhesion_protein-1 and serves as its substrate .
19761765	0	vascular_adhesion_protein-1	16,43	VAP-1	45,50	vascular adhesion protein-1	VAP-1	8639	8639	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- in the human eye .
23337801	0	vascular_adhesion_protein-1	55,82	VAP-1	84,89	vascular adhesion protein-1	VAP-1	8639	8639	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and SAR study of new thiazole derivatives as vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- inhibitors for the treatment of diabetic macular_edema .
23540955	0	vascular_adhesion_protein-1	55,82	VAP-1	84,89	vascular adhesion protein-1	VAP-1	8639	8639	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Synthesis and SAR study of new thiazole derivatives as vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- inhibitors for the treatment of diabetic_macular_edema : part 2 .
23664164	0	vascular_adhesion_protein-1	66,93	VAP-1	95,100	vascular adhesion protein-1	VAP-1	8639	8639	Gene	Gene	inhibitors|amod|START_ENTITY inhibitors|appos|END_ENTITY	Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular_adhesion_protein-1 -LRB- VAP-1 -RRB- inhibitors for diabetic_macular_edema treatment .
23421430	0	vascular_cell_adhesion_molecule	28,59	IL-17	0,5	vascular cell adhesion molecule	IL-17	7412	3605	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	IL-17 induces expression of vascular_cell_adhesion_molecule through signalling pathway of NF-kB , but not Akt1 and TAK1 in vascular smooth muscle cells .
7679554	0	vascular_cell_adhesion_molecule	14,45	VCAM-1	47,53	vascular cell adhesion molecule	VCAM-1	7412	7412	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_cell_adhesion_molecule -LRB- VCAM-1 -RRB- in liver and pancreas allograft rejection .
18227124	0	vascular_cell_adhesion_molecule-1	75,108	Akt	127,130	vascular cell adhesion molecule-1	Akt	7412	207	Gene	Gene	START_ENTITY|nmod|activation activation|nmod|END_ENTITY	Tumor_necrosis_factor-alpha enhances neutrophil adhesiveness : induction of vascular_cell_adhesion_molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone_deacetylase_4 in human tracheal smooth muscle cells .
10484544	0	vascular_cell_adhesion_molecule-1	23,56	Angiotensin_II	0,14	vascular cell adhesion molecule-1	Angiotensin II	25361(Tax:10116)	24179(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Angiotensin_II induces vascular_cell_adhesion_molecule-1 expression in rat vasculature : A potential link between the renin-angiotensin system and atherosclerosis .
10712386	0	vascular_cell_adhesion_molecule-1	38,71	Angiotensin_II	0,14	vascular cell adhesion molecule-1	Angiotensin II	7412	183	Gene	Gene	stimulates|dobj|START_ENTITY stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates endothelial vascular_cell_adhesion_molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress .
16894036	0	vascular_cell_adhesion_molecule-1	42,75	Apolipoprotein_CIII	0,19	vascular cell adhesion molecule-1	Apolipoprotein CIII	7412	345	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	Apolipoprotein_CIII induces expression of vascular_cell_adhesion_molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells .
23313051	0	vascular_cell_adhesion_molecule-1	13,46	CCN4	0,4	vascular cell adhesion molecule-1	CCN4	7412	8840	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	CCN4 induces vascular_cell_adhesion_molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion .
16430914	0	vascular_cell_adhesion_molecule-1	75,108	CD32	128,132	vascular cell adhesion molecule-1	CD32	7412	2212	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	C-reactive_protein activates the nuclear factor-kappaB pathway and induces vascular_cell_adhesion_molecule-1 expression through CD32 in human umbilical vein endothelial cells and aortic endothelial cells .
18269829	0	vascular_cell_adhesion_molecule-1	41,74	CD40L	27,32	vascular cell adhesion molecule-1	CD40L	7412	959	Gene	Gene	expression|amod|START_ENTITY induced|dobj|expression END_ENTITY|acl|induced	-LSB- Simvastatin downregulates CD40L induced vascular_cell_adhesion_molecule-1 expression and adhesive function in human umbilical vein endothelial cells -RSB- .
10206185	0	vascular_cell_adhesion_molecule-1	22,55	Endothelin-1	0,12	vascular cell adhesion molecule-1	Endothelin-1	7412	1906	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Endothelin-1 enhances vascular_cell_adhesion_molecule-1 expression in tumor_necrosis_factor_alpha-stimulated vascular endothelial cells .
7529288	0	vascular_cell_adhesion_molecule-1	26,59	IL-13	0,5	vascular cell adhesion molecule-1	IL-13	7412	3596	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	IL-13 selectively induces vascular_cell_adhesion_molecule-1 expression in human endothelial cells .
10430178	0	vascular_cell_adhesion_molecule-1	13,46	IL-4	61,65	vascular cell adhesion molecule-1	IL-4	7412	3565	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of vascular_cell_adhesion_molecule-1 expression by IL-4 in human aortic smooth muscle cells is not associated with increased nuclear NF-kappaB levels .
1698865	0	vascular_cell_adhesion_molecule-1	117,150	IL-4	0,4	vascular cell adhesion molecule-1	IL-4	7412	3565	Gene	Gene	induction|nmod|START_ENTITY microvascular|nmod|induction promote|advcl|microvascular acts|xcomp|promote acts|nsubj|END_ENTITY	IL-4 acts synergistically with IL-1_beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular_cell_adhesion_molecule-1 .
7529260	0	vascular_cell_adhesion_molecule-1	14,47	IL-4	62,66	vascular cell adhesion molecule-1	IL-4	7412	3565	Gene	Gene	expression|amod|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vascular_cell_adhesion_molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells .
8639787	0	vascular_cell_adhesion_molecule-1	101,134	IL-4	15,19	vascular cell adhesion molecule-1	IL-4	7412	3565	Gene	Gene	induction|amod|START_ENTITY mediating|dobj|induction Interleukin-4|acl|mediating Interleukin-4|appos|END_ENTITY	Interleukin-4 -LRB- IL-4 -RRB- and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular_cell_adhesion_molecule-1 induction in the absence of the common_gamma_chain .
7556668	0	vascular_cell_adhesion_molecule-1	34,67	Interleukin-4	0,13	vascular cell adhesion molecule-1	Interleukin-4	7412	3565	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Interleukin-4 induces endothelial vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by an NF-kappa_b-independent mechanism .
8639787	0	vascular_cell_adhesion_molecule-1	101,134	Interleukin-4	0,13	vascular cell adhesion molecule-1	Interleukin-4	7412	3565	Gene	Gene	induction|amod|START_ENTITY mediating|dobj|induction END_ENTITY|acl|mediating	Interleukin-4 -LRB- IL-4 -RRB- and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular_cell_adhesion_molecule-1 induction in the absence of the common_gamma_chain .
9569232	0	vascular_cell_adhesion_molecule-1	57,90	Interleukin-4	0,13	vascular cell adhesion molecule-1	Interleukin-4	7412	3565	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression synergize|xcomp|induce synergize|nsubj|END_ENTITY	Interleukin-4 and lipopolysaccharide synergize to induce vascular_cell_adhesion_molecule-1 expression in human lung microvascular endothelial cells .
7537041	0	vascular_cell_adhesion_molecule-1	83,116	Tumor_necrosis_factor_alpha	0,27	vascular cell adhesion molecule-1	Tumor necrosis factor alpha	22329(Tax:10090)	21926(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Tumor_necrosis_factor_alpha and interleukin-1_beta but not interferon_gamma induce vascular_cell_adhesion_molecule-1 expression on primary cultured murine hepatocytes .
10022460	0	vascular_cell_adhesion_molecule-1	61,94	VCAM-1	96,102	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Selective estrogen receptor modulators : different actions on vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human endothelial cells .
11223433	0	vascular_cell_adhesion_molecule-1	36,69	VCAM-1	71,77	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Selective inhibition by probucol of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human vascular endothelial cells .
11590165	0	vascular_cell_adhesion_molecule-1	55,88	VCAM-1	90,96	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Cell-derived apolipoprotein_E -LRB- ApoE -RRB- particles inhibit vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression in human endothelial cells .
15001568	0	vascular_cell_adhesion_molecule-1	92,125	VCAM-1	127,133	vascular cell adhesion molecule-1	VCAM-1	25361(Tax:10116)	25361(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Angiotensin_II differentially regulates interleukin-1-beta-inducible_NO_synthase -LRB- iNOS -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression : role of p38 MAPK .
15372288	0	vascular_cell_adhesion_molecule-1	14,47	VCAM-1	49,55	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	concentrations|amod|START_ENTITY concentrations|appos|END_ENTITY	Serum soluble vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- concentrations in children with reflux_nephropathy .
15553662	0	vascular_cell_adhesion_molecule-1	111,144	VCAM-1	146,152	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Nifedipine inhibits tumor_necrosis_factor-alpha-induced leukocyte adhesion to endothelial cells by suppressing vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression .
22970700	0	vascular_cell_adhesion_molecule-1	26,59	VCAM-1	61,67	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	domain|amod|START_ENTITY domain|appos|END_ENTITY	Distinct sites within the vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- cytoplasmic domain regulate VCAM-1 activation of calcium fluxes versus Rac1 during leukocyte transendothelial migration .
7508348	0	vascular_cell_adhesion_molecule-1	47,80	VCAM-1	82,88	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Intercellular_adhesion_molecule-1 -LRB- ICAM-1 -RRB- and vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression and function on cultured human glomerular epithelial cells .
7530745	0	vascular_cell_adhesion_molecule-1	31,64	VCAM-1	66,72	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Cytokine-induced expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by astrocytes and astrocytoma cell lines .
7542574	0	vascular_cell_adhesion_molecule-1	64,97	VCAM-1	99,105	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Allergen-stimulated T lymphocytes from allergic patients induce vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- expression and IL-6 production by endothelial cells .
7551271	0	vascular_cell_adhesion_molecule-1	25,58	VCAM-1	60,66	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Concentration of soluble vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- correlated with expression of VCAM-1 mRNA in the human atherosclerotic aorta .
7556668	0	vascular_cell_adhesion_molecule-1	34,67	VCAM-1	69,75	vascular cell adhesion molecule-1	VCAM-1	7412	7412	Gene	Gene	induces|dobj|START_ENTITY induces|dep|END_ENTITY	Interleukin-4 induces endothelial vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- by an NF-kappa_b-independent mechanism .
9050772	0	vascular_cell_adhesion_molecule-1	14,47	VCAM-1	49,55	vascular cell adhesion molecule-1	VCAM-1	100008901(Tax:9986)	100008901(Tax:9986)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM-1 -RRB- in the aortae of hypercholesterolemic rabbits with high -LRB- HAR -RRB- and low -LRB- LAR -RRB- atherosclerotic response .
7506959	0	vascular_cell_adhesion_molecule-1	64,97	VCAM1	99,104	vascular cell adhesion molecule-1	VCAM1	7412	7412	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Expression and functional characterization of recombinant human vascular_cell_adhesion_molecule-1 -LRB- VCAM1 -RRB- synthesized by baculovirus-infected insect cells .
24554512	0	vascular_cell_adhesion_molecule-1	132,165	c-reactive_protein	86,104	vascular cell adhesion molecule-1	c-reactive protein	7412	1401	Gene	Gene	concentrations|amod|START_ENTITY concentrations|amod|END_ENTITY	Effects of metformin or an oral contraceptive containing cyproterone_acetate on serum c-reactive_protein , interleukin-6 and soluble vascular_cell_adhesion_molecule-1 concentrations in women with polycystic_ovary_syndrome .
23117931	0	vascular_cell_adhesion_molecule-1	97,130	cyclooxygenase-2	79,95	vascular cell adhesion molecule-1	cyclooxygenase-2	7412	5743	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The androgen metabolite , 5a-androstane-3b ,17 b-diol , decreases cytokine-induced cyclooxygenase-2 , vascular_cell_adhesion_molecule-1 expression , and P-glycoprotein expression in male human brain microvascular endothelial cells .
11775908	0	vascular_cell_adhesion_molecule-1	97,130	intercellular_cell_adhesion_molecule-1	57,95	vascular cell adhesion molecule-1	intercellular cell adhesion molecule-1	7412	3383	Gene	Gene	cells|amod|START_ENTITY cells|amod|END_ENTITY	-LSB- Inhibitory effects of ligustrazine on the expression of intercellular_cell_adhesion_molecule-1 , vascular_cell_adhesion_molecule-1 in human umbilical vein endothelial cells induced by preeclamptic plasma -RSB- .
22595111	0	vascular_cell_adhesion_molecule-1	14,47	interleukin-1b	72,86	vascular cell adhesion molecule-1	interleukin-1b	7412	3553	Gene	Gene	cells|amod|START_ENTITY cells|nmod|END_ENTITY	Regulation of vascular_cell_adhesion_molecule-1 in dental pulp cells by interleukin-1b : the role of prostanoids .
12006387	0	vascular_cell_adhesion_molecule-1	113,146	isoprenylcysteine_carboxyl_methyltransferase	8,52	vascular cell adhesion molecule-1	isoprenylcysteine carboxyl methyltransferase	7412	23463	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of isoprenylcysteine_carboxyl_methyltransferase in tumor_necrosis_factor-alpha stimulation of expression of vascular_cell_adhesion_molecule-1 in endothelial cells .
17085432	0	vascular_cell_adhesion_molecule-1	92,125	neutral_sphingomyelinase-2	9,35	vascular cell adhesion molecule-1	neutral sphingomyelinase-2	7412	55512	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Role for neutral_sphingomyelinase-2 in tumor_necrosis_factor_alpha-stimulated expression of vascular_cell_adhesion_molecule-1 -LRB- VCAM -RRB- and intercellular_adhesion_molecule-1 -LRB- ICAM -RRB- in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 .
22093181	0	vascular_cell_adhesion_molecule-1	70,103	tumor_necrosis_factor-alpha	17,44	vascular cell adhesion molecule-1	tumor necrosis factor-alpha	7412	7124	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells expression|amod|END_ENTITY	Insulin augments tumor_necrosis_factor-alpha stimulated expression of vascular_cell_adhesion_molecule-1 in vascular endothelial cells .
8547644	0	vascular_cell_adhesion_molecule-1	27,60	tumor_necrosis_factor_alpha	83,110	vascular cell adhesion molecule-1	tumor necrosis factor alpha	7412	7124	Gene	Gene	gene|amod|START_ENTITY regulation|nmod|gene transcription|nsubj|regulation transcription|nmod|END_ENTITY	Differential regulation of vascular_cell_adhesion_molecule-1 gene transcription by tumor_necrosis_factor_alpha and interleukin-1_alpha in dermal microvascular endothelial cells .
15576639	0	vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1	48,124	Superoxide_dismutase	0,20	vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1	Superoxide dismutase	7412	6647	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Superoxide_dismutase inhibits the expression of vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1 induced by tumor_necrosis_factor-alpha in human endothelial cells through the JNK/p38 pathways .
15576639	0	vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1	48,124	tumor_necrosis_factor-alpha	136,163	vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1	tumor necrosis factor-alpha	7412	7124	Gene	Gene	START_ENTITY|acl|induced induced|nmod|END_ENTITY	Superoxide_dismutase inhibits the expression of vascular_cell_adhesion_molecule-1_and_intracellular_cell_adhesion_molecule-1 induced by tumor_necrosis_factor-alpha in human endothelial cells through the JNK/p38 pathways .
7692229	0	vascular_cell_adhesion_molecule_1	27,60	NF-kappa_B	89,99	vascular cell adhesion molecule 1	NF-kappa B	7412	4790	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Differential regulation of vascular_cell_adhesion_molecule_1 gene expression by specific NF-kappa_B subunits in endothelial and epithelial cells .
12547825	0	vascular_cell_adhesion_molecule_1	83,116	VCAM-1	118,124	vascular cell adhesion molecule 1	VCAM-1	7412	7412	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	17-epiestriol , an estrogen metabolite , is more potent than estradiol in inhibiting vascular_cell_adhesion_molecule_1 -LRB- VCAM-1 -RRB- mRNA expression .
17785844	0	vascular_endothelial_cadherin	41,70	Src	17,20	vascular endothelial cadherin	Src	1003	6714	Gene	Gene	phosphorylation|compound|START_ENTITY phosphorylation|amod|END_ENTITY	ICAM-1-mediated , Src - and Pyk2-dependent vascular_endothelial_cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration .
11950700	0	vascular_endothelial_cadherin	64,93	Vascular_endothelial_growth_factor	0,34	vascular endothelial cadherin	Vascular endothelial growth factor	1003	7422	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Vascular_endothelial_growth_factor induces SHC association with vascular_endothelial_cadherin : a potential feedback mechanism to control vascular_endothelial_growth_factor receptor-2 signaling .
20811903	0	vascular_endothelial_cadherin	72,101	Wt1	22,25	vascular endothelial cadherin	Wt1	12562(Tax:10090)	22431(Tax:10090)	Gene	Gene	transcription|nmod|START_ENTITY stimulates|dobj|transcription stimulates|nsubj|END_ENTITY	Wilms ' _ tumour protein Wt1 stimulates transcription of the gene encoding vascular_endothelial_cadherin .
11950700	0	vascular_endothelial_cadherin	64,93	vascular_endothelial_growth_factor	137,171	vascular endothelial cadherin	vascular endothelial growth factor	1003	7422	Gene	Gene	induces|nmod|START_ENTITY induces|advcl|control control|dobj|signaling signaling|amod|END_ENTITY	Vascular_endothelial_growth_factor induces SHC association with vascular_endothelial_cadherin : a potential feedback mechanism to control vascular_endothelial_growth_factor receptor-2 signaling .
18180305	0	vascular_endothelial_cadherin	16,45	vascular_endothelial_growth_factor	105,139	vascular endothelial cadherin	vascular endothelial growth factor	1003	7422	Gene	Gene	START_ENTITY|acl|modulating modulating|dobj|activation activation|nmod|END_ENTITY	A novel role of vascular_endothelial_cadherin in modulating c-Src activation and downstream signaling of vascular_endothelial_growth_factor .
10748050	0	vascular_endothelial_cell_growth_factor	85,124	Flt1	47,51	vascular endothelial cell growth factor	Flt1	7422	2321	Gene	Gene	receptor|compound|START_ENTITY expression|nmod|receptor expression|amod|END_ENTITY	Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- receptor mRNAs by VEGF .
16258288	0	vascular_endothelial_cell_growth_factor	26,65	Thrombopoietin	0,14	vascular endothelial cell growth factor	Thrombopoietin	7422	7066	Gene	Gene	production|amod|START_ENTITY stimulates|dobj|production stimulates|nsubj|END_ENTITY	Thrombopoietin stimulates vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- production in hematopoietic stem cells .
10748050	0	vascular_endothelial_cell_growth_factor	85,124	VEGF	126,130	vascular endothelial cell growth factor	VEGF	7422	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Homeostatic modulation of cell surface KDR and Flt1 expression and expression of the vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- receptor mRNAs by VEGF .
24574253	0	vascular_endothelial_cell_growth_factor	27,66	VEGF	68,72	vascular endothelial cell growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Constitutive expression of vascular_endothelial_cell_growth_factor -LRB- VEGF -RRB- gene family ligand and receptors on human upper and lower airway epithelial cells .
11742867	0	vascular_endothelial_cell_growth_factor	89,128	kinase_insert_domain-containing_receptor	143,183	vascular endothelial cell growth factor	kinase insert domain-containing receptor	7422	3791	Gene	Gene	receptor-2|compound|START_ENTITY receptor-2|appos|END_ENTITY	Vascular_endothelial_cell_growth_factor-driven endothelial tube formation is mediated by vascular_endothelial_cell_growth_factor receptor-2 , a kinase_insert_domain-containing_receptor .
12213803	0	vascular_endothelial_cell_growth_factor	12,51	vascular_permeability_factor	52,80	vascular endothelial cell growth factor	vascular permeability factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	START_ENTITY|parataxis|signaling signaling|nsubj|END_ENTITY	Deciphering vascular_endothelial_cell_growth_factor / vascular_permeability_factor signaling to vascular permeability .
26483143	0	vascular_endothelial_growth_factor	25,59	ANGPTL-4	0,8	vascular endothelial growth factor	ANGPTL-4	7422	51129	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|END_ENTITY	ANGPTL-4 correlates with vascular_endothelial_growth_factor in patients with proliferative diabetic_retinopathy .
19883500	0	vascular_endothelial_growth_factor	101,135	Adiponectin	0,11	vascular endothelial growth factor	Adiponectin	7422	9370	Gene	Gene	stimulating|xcomp|START_ENTITY contribute|advcl|stimulating contribute|nsubj|END_ENTITY	Adiponectin may contribute to synovitis and joint destruction in rheumatoid_arthritis by stimulating vascular_endothelial_growth_factor , matrix metalloproteinase-1 , and matrix_metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators .
10347193	0	vascular_endothelial_growth_factor	52,86	Akt	0,3	vascular endothelial growth factor	Akt	7422	207	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Akt mediates cytoprotection of endothelial cells by vascular_endothelial_growth_factor in an anchorage-dependent manner .
17008323	0	vascular_endothelial_growth_factor	24,58	Akt	144,147	vascular endothelial growth factor	Akt	7422	207	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|END_ENTITY	Ginsenoside-Rg1 induces vascular_endothelial_growth_factor expression through the glucocorticoid_receptor-related phosphatidylinositol_3-kinase / Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells .
17203218	0	vascular_endothelial_growth_factor	138,172	Akt	133,136	vascular endothelial growth factor	Akt	22339(Tax:10090)	207	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	S-1 inhibits tumorigenicity and angiogenesis of human oral_squamous_cell_carcinoma cells by suppressing expression of phosphorylated Akt , vascular_endothelial_growth_factor and fibroblast_growth_factor-2 .
17483438	0	vascular_endothelial_growth_factor	27,61	Akt	65,68	vascular endothelial growth factor	Akt	7422	207	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|inhibitors inhibitors|compound|END_ENTITY	Differential regulation of vascular_endothelial_growth_factor by Akt and mammalian_target_of_rapamycin inhibitors in cell lines derived from childhood solid_tumors .
21351097	0	vascular_endothelial_growth_factor	14,48	Akt3	0,4	vascular endothelial growth factor	Akt3	7422	10000	Gene	Gene	secretion|compound|START_ENTITY controls|dobj|secretion controls|nsubj|END_ENTITY	Akt3 controls vascular_endothelial_growth_factor secretion and angiogenesis in ovarian_cancer cells .
15095288	0	vascular_endothelial_growth_factor	54,88	Angiopoietin-2	0,14	vascular endothelial growth factor	Angiopoietin-2	22339(Tax:10090)	11601(Tax:10090)	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	Angiopoietin-2 enhances retinal vessel sensitivity to vascular_endothelial_growth_factor .
17704802	0	vascular_endothelial_growth_factor	25,59	Angiopoietin-2	0,14	vascular endothelial growth factor	Angiopoietin-2	7422	285	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Angiopoietin-2 decreases vascular_endothelial_growth_factor expression by modulating HIF-1_alpha levels in gliomas .
21163623	0	vascular_endothelial_growth_factor	87,121	Angiopoietin-2	0,14	vascular endothelial growth factor	Angiopoietin-2	22339(Tax:10090)	11601(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY affecting|dobj|expression inhibits|advcl|affecting inhibits|nsubj|END_ENTITY	Angiopoietin-2 inhibits the growth of tongue_carcinoma without affecting expression of vascular_endothelial_growth_factor .
12065685	0	vascular_endothelial_growth_factor	50,84	Angiotensin_II	0,14	vascular endothelial growth factor	Angiotensin II	22339(Tax:10090)	11606(Tax:10090)	Gene	Gene	pathways|amod|START_ENTITY involves|dobj|pathways involves|nsubj|effect effect|compound|END_ENTITY	Angiotensin_II angiogenic effect in vivo involves vascular_endothelial_growth_factor - and inflammation-related pathways .
12110003	0	vascular_endothelial_growth_factor	29,63	Angiotensin_II	0,14	vascular endothelial growth factor	Angiotensin II	83785(Tax:10116)	24179(Tax:10116)	Gene	Gene	Flt-1|compound|START_ENTITY regulation|nmod|Flt-1 regulation|compound|END_ENTITY	Angiotensin_II regulation of vascular_endothelial_growth_factor and receptors Flt-1 and KDR/Flk -1 in cyclosporine nephrotoxicity .
16115033	0	vascular_endothelial_growth_factor	25,59	Angiotensin_II	0,14	vascular endothelial growth factor	Angiotensin II	83785(Tax:10116)	24179(Tax:10116)	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Angiotensin_II regulates vascular_endothelial_growth_factor via hypoxia-inducible factor-1alpha induction and redox mechanisms in the kidney .
16595708	0	vascular_endothelial_growth_factor	43,77	Angiotensin_II	0,14	vascular endothelial growth factor	Angiotensin II	22339(Tax:10090)	11606(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY stimulates|dobj|synthesis stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates the synthesis of vascular_endothelial_growth_factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytes .
18026817	0	vascular_endothelial_growth_factor	23,57	Angiotensin_II	0,14	vascular endothelial growth factor	Angiotensin II	83785(Tax:10116)	24179(Tax:10116)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Angiotensin_II induces vascular_endothelial_growth_factor in pancreatic_cancer cells through an angiotensin_II_type_1_receptor and ERK1/2 signaling .
18973754	0	vascular_endothelial_growth_factor	23,57	Angiotensin_II	0,14	vascular endothelial growth factor	Angiotensin II	7422	183	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Angiotensin_II induces vascular_endothelial_growth_factor synthesis in mesenchymal stem cells .
12393646	0	vascular_endothelial_growth_factor	30,64	BCR/ABL	0,7	vascular endothelial growth factor	BCR/ABL	7422	25	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	BCR/ABL induces expression of vascular_endothelial_growth_factor and its transcriptional activator , hypoxia inducible factor-1alpha , through a pathway involving phosphoinositide 3-kinase and the mammalian_target_of_rapamycin .
11127202	0	vascular_endothelial_growth_factor	42,76	Basic_fibroblast_growth_factor	0,30	vascular endothelial growth factor	Basic fibroblast growth factor	22339(Tax:10090)	14173(Tax:10090)	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor stimulates vascular_endothelial_growth_factor release in osteoblasts : divergent regulation by p42/p44 mitogen-activated protein kinase and p38 mitogen-activated protein kinase .
11263242	0	vascular_endothelial_growth_factor	62,96	Basic_fibroblast_growth_factor	0,30	vascular endothelial growth factor	Basic fibroblast growth factor	83785(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY up-regulates|dobj|expression up-regulates|nsubj|END_ENTITY	Basic_fibroblast_growth_factor up-regulates the expression of vascular_endothelial_growth_factor in primary cultured rat astrocytes .
10744622	0	vascular_endothelial_growth_factor	65,99	Bcl-2	0,5	vascular endothelial growth factor	Bcl-2	7422	596	Gene	Gene	expression|compound|START_ENTITY act|nmod|expression act|nsubj|overexpression overexpression|compound|END_ENTITY	Bcl-2 overexpression and hypoxia synergistically act to modulate vascular_endothelial_growth_factor expression and in vivo angiogenesis in a breast_carcinoma line .
25225463	0	vascular_endothelial_growth_factor	59,93	Bcl2	53,57	vascular endothelial growth factor	Bcl2	7422	596	Gene	Gene	epidermal|dep|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
22943534	0	vascular_endothelial_growth_factor	54,88	Bone_morphogenetic_protein_4	0,28	vascular endothelial growth factor	Bone morphogenetic protein 4	281572(Tax:9913)	407216(Tax:9913)	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Bone_morphogenetic_protein_4 -LRB- BMP-4 -RRB- and BMP-7 induce vascular_endothelial_growth_factor expression in bovine granulosa cells .
24225154	0	vascular_endothelial_growth_factor	20,54	Bradykinin	0,10	vascular endothelial growth factor	Bradykinin	7422	3827	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Bradykinin promotes vascular_endothelial_growth_factor expression and increases angiogenesis in human prostate_cancer cells .
16618748	0	vascular_endothelial_growth_factor	61,95	Brain-derived_neurotrophic_factor	0,33	vascular endothelial growth factor	Brain-derived neurotrophic factor	7422	627	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|activation activation|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
25150213	0	vascular_endothelial_growth_factor	44,78	Brain-derived_neurotrophic_factor	0,33	vascular endothelial growth factor	Brain-derived neurotrophic factor	7422	627	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor increases vascular_endothelial_growth_factor expression and enhances angiogenesis in human chondrosarcoma cells .
19302556	0	vascular_endothelial_growth_factor	6,40	C-reactive_protein	116,134	vascular endothelial growth factor	C-reactive protein	7422	1401	Gene	Gene	START_ENTITY|dep|comparison comparison|nmod|END_ENTITY	Serum vascular_endothelial_growth_factor in adult haematological patients with neutropenic_fever : a comparison with C-reactive_protein .
25444917	0	vascular_endothelial_growth_factor	14,48	CCL5	0,4	vascular endothelial growth factor	CCL5	7422	6352	Gene	Gene	expression|compound|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	CCL5 promotes vascular_endothelial_growth_factor expression and induces angiogenesis by down-regulating miR-199a in human chondrosarcoma cells .
10799861	0	vascular_endothelial_growth_factor	66,100	CD40	0,4	vascular endothelial growth factor	CD40	7422	958	Gene	Gene	production|nmod|START_ENTITY engagement|nmod|production engagement|nsubj|END_ENTITY	CD40 engagement on synovial fibroblast up-regulates production of vascular_endothelial_growth_factor .
11090063	0	vascular_endothelial_growth_factor	43,77	CD40	12,16	vascular endothelial growth factor	CD40	7422	958	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|Ligation Ligation|nmod|END_ENTITY	Ligation of CD40 induces the expression of vascular_endothelial_growth_factor by endothelial cells and monocytes and promotes angiogenesis in vivo .
11830495	0	vascular_endothelial_growth_factor	38,72	CD40	0,4	vascular endothelial growth factor	CD40	7422	958	Gene	Gene	secretion|compound|START_ENTITY induces|dobj|secretion induces|nsubj|activation activation|compound|END_ENTITY	CD40 activation induces p53-dependent vascular_endothelial_growth_factor secretion in human multiple_myeloma cells .
18079224	0	vascular_endothelial_growth_factor	39,73	CD40	24,28	vascular endothelial growth factor	CD40	7422	958	Gene	Gene	ligand|nmod|START_ENTITY ligand|nsubj|Relationship Relationship|nmod|END_ENTITY	Relationship of soluble CD40 ligand to vascular_endothelial_growth_factor , angiopoietins , and tissue factor in atrial_fibrillation : a link among platelet activation , angiogenesis , and thrombosis ?
20303602	0	vascular_endothelial_growth_factor	24,58	CD40	0,4	vascular endothelial growth factor	CD40	7422	958	Gene	Gene	regulator|nmod|START_ENTITY regulator|nsubj|END_ENTITY	CD40 is a regulator for vascular_endothelial_growth_factor in the tumor microenvironment of glioma .
20364320	0	vascular_endothelial_growth_factor	13,47	CD47	83,87	vascular endothelial growth factor	CD47	7422	961	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor and matrix_metalloproteinase-9 via CD47 signaling in neurovascular cells .
20978203	0	vascular_endothelial_growth_factor	86,120	COUP-TFII	17,26	vascular endothelial growth factor	COUP-TFII	7422	7026	Gene	Gene	regulating|dobj|START_ENTITY controls|advcl|regulating controls|nsubj|END_ENTITY	Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular_endothelial_growth_factor / vascular_endothelial_growth_factor receptor-2 signaling .
16084492	0	vascular_endothelial_growth_factor	92,126	CXCR4	33,38	vascular endothelial growth factor	CXCR4	7422	7852	Gene	Gene	production|nmod|START_ENTITY promotes|dobj|production promotes|nsubj|Activation Activation|nmod|END_ENTITY	Activation of chemokine receptor CXCR4 in malignant_glioma cells promotes the production of vascular_endothelial_growth_factor .
21087342	0	vascular_endothelial_growth_factor	77,111	CXCR4	18,23	vascular endothelial growth factor	CXCR4	7422	7852	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	The expression of CXCR4 and its relationship with matrix_metalloproteinase-9 / vascular_endothelial_growth_factor in esophageal squamous_cell_cancer .
16904202	0	vascular_endothelial_growth_factor	60,94	Calcitonin_gene-related_peptide	0,31	vascular endothelial growth factor	Calcitonin gene-related peptide	7422	796	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Calcitonin_gene-related_peptide regulates the expression of vascular_endothelial_growth_factor in human HaCaT keratinocytes by activation of ERK1/2 MAPK .
19035510	0	vascular_endothelial_growth_factor	66,100	Cited2	0,6	vascular endothelial growth factor	Cited2	83785(Tax:10116)	114490(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Cited2 modulates hypoxia-inducible factor-dependent expression of vascular_endothelial_growth_factor in nucleus pulposus cells of the rat intervertebral disc .
11744618	0	vascular_endothelial_growth_factor	38,72	Connective_tissue_growth_factor	0,31	vascular endothelial growth factor	Connective tissue growth factor	22339(Tax:10090)	14219(Tax:10090)	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Connective_tissue_growth_factor binds vascular_endothelial_growth_factor -LRB- VEGF -RRB- and inhibits VEGF-induced angiogenesis .
12605268	0	vascular_endothelial_growth_factor	73,107	Connective_tissue_growth_factor	0,31	vascular endothelial growth factor	Connective tissue growth factor	7422	1490	Gene	Gene	presence|nmod|START_ENTITY END_ENTITY|dep|presence	Connective_tissue_growth_factor in pterygium : simultaneous presence with vascular_endothelial_growth_factor - possible contributing factor to conjunctival scarring .
19852986	0	vascular_endothelial_growth_factor	43,77	Corticotropin-releasing_hormone	0,31	vascular endothelial growth factor	Corticotropin-releasing hormone	7422	1392	Gene	Gene	START_ENTITY|nsubj|attenuates attenuates|amod|END_ENTITY	Corticotropin-releasing_hormone attenuates vascular_endothelial_growth_factor release from human HaCaT keratinocytes .
23991063	0	vascular_endothelial_growth_factor	38,72	Cyclin_A1	0,9	vascular endothelial growth factor	Cyclin A1	7422	8900	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Cyclin_A1 modulates the expression of vascular_endothelial_growth_factor and promotes hormone-dependent growth and angiogenesis of breast_cancer .
10821793	0	vascular_endothelial_growth_factor	100,134	Cyclo-oxygenase-2	0,17	vascular endothelial growth factor	Cyclo-oxygenase-2	83785(Tax:10116)	29527(Tax:10116)	Gene	Gene	induction|nmod|START_ENTITY enhances|nmod|induction enhances|nsubj|END_ENTITY	Cyclo-oxygenase-2 enhances basic_fibroblast_growth_factor-induced angiogenesis through induction of vascular_endothelial_growth_factor in rat sponge implants .
11957147	0	vascular_endothelial_growth_factor	104,138	Cyclooxygenase-2	0,16	vascular endothelial growth factor	Cyclooxygenase-2	7422	5743	Gene	Gene	correlation|nmod|START_ENTITY expression|dep|correlation expression|amod|END_ENTITY	Cyclooxygenase-2 expression in endometrial_cancer : correlation with microvessel count and expression of vascular_endothelial_growth_factor and thymidine_phosphorylase .
12811205	0	vascular_endothelial_growth_factor	48,82	Cyclooxygenase-2	0,16	vascular endothelial growth factor	Cyclooxygenase-2	7422	5743	Gene	Gene	expression|compound|START_ENTITY correlates|nmod|expression correlates|amod|END_ENTITY	Cyclooxygenase-2 overexpression correlates with vascular_endothelial_growth_factor expression and tumor angiogenesis in gastric_cancer .
14532971	0	vascular_endothelial_growth_factor	29,63	Cyclooxygenase-2	0,16	vascular endothelial growth factor	Cyclooxygenase-2	7422	5743	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Cyclooxygenase-2 upregulates vascular_endothelial_growth_factor expression and angiogenesis in human gastric_carcinoma .
15375582	0	vascular_endothelial_growth_factor	124,158	Cyclooxygenase-2	0,16	vascular endothelial growth factor	Cyclooxygenase-2	7422	5743	Gene	Gene	expression|nmod|START_ENTITY density|appos|expression correlations|nmod|density END_ENTITY|dep|correlations	Cyclooxygenase-2 in human malignant_fibrous_histiocytoma : correlations with intratumoral microvessel density , expression of vascular_endothelial_growth_factor and thymidine_phosphorylase .
15883203	0	vascular_endothelial_growth_factor	37,71	Cyclooxygenase-2	0,16	vascular endothelial growth factor	Cyclooxygenase-2	7422	5743	Gene	Gene	expression|compound|START_ENTITY inhibitors|dobj|expression inhibitors|nsubj|END_ENTITY	Cyclooxygenase-2 inhibitors decrease vascular_endothelial_growth_factor expression in colon_cancer cells by enhanced degradation of Sp1 and Sp4 proteins .
15968728	0	vascular_endothelial_growth_factor	53,87	Cyclooxygenase-2	0,16	vascular endothelial growth factor	Cyclooxygenase-2	7422	5743	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Cyclooxygenase-2 promotes angiogenesis by increasing vascular_endothelial_growth_factor and predicts prognosis in gallbladder_carcinoma .
21219643	0	vascular_endothelial_growth_factor	30,64	Cyclooxygenase-2	0,16	vascular endothelial growth factor	Cyclooxygenase-2	7422	5743	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Cyclooxygenase-2 up-regulates vascular_endothelial_growth_factor via a protein_kinase_C pathway in non-small_cell_lung_cancer .
18233956	0	vascular_endothelial_growth_factor	77,111	DEC2	51,55	vascular endothelial growth factor	DEC2	22339(Tax:10090)	79362(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Basic-helix-loop-helix -LRB- bHLH -RRB- transcription factor DEC2 negatively regulates vascular_endothelial_growth_factor expression .
16574895	0	vascular_endothelial_growth_factor	52,86	Dimethylarginine_dimethylaminohydrolase_2	0,41	vascular endothelial growth factor	Dimethylarginine dimethylaminohydrolase 2	7422	23564	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Dimethylarginine_dimethylaminohydrolase_2 increases vascular_endothelial_growth_factor expression through Sp1 transcription factor in endothelial cells .
16778084	0	vascular_endothelial_growth_factor	14,48	EMMPRIN	63,70	vascular endothelial growth factor	EMMPRIN	7422	682	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by EMMPRIN via the PI3K-Akt signaling pathway .
10733912	0	vascular_endothelial_growth_factor	24,58	ERK	77,80	vascular endothelial growth factor	ERK	7422	5594	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Different regulation of vascular_endothelial_growth_factor expression by the ERK and p38 kinase pathways in v-ras , v-raf , and v-myc transformed cells .
21263382	0	vascular_endothelial_growth_factor	49,83	ERK	98,101	vascular endothelial growth factor	ERK	22339(Tax:10090)	26413(Tax:10090)	Gene	Gene	production|compound|START_ENTITY stem|dobj|production stem|nmod|- -|compound|END_ENTITY	IL-6 and TGF-a costimulate mesenchymal stem cell vascular_endothelial_growth_factor production by ERK - , JNK - , and PI3K-mediated mechanisms .
19148513	0	vascular_endothelial_growth_factor	18,52	Efp	102,105	vascular endothelial growth factor	Efp	7422	7706	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of the vascular_endothelial_growth_factor and growth by estrogen and antiestrogens through Efp in Ishikawa endometrial_carcinoma cells .
15737464	0	vascular_endothelial_growth_factor	32,66	Egr-1	71,76	vascular endothelial growth factor	Egr-1	83785(Tax:10116)	24330(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Prolactin-induced expression of vascular_endothelial_growth_factor via Egr-1 .
15876483	0	vascular_endothelial_growth_factor	64,98	Endostatin	0,10	vascular endothelial growth factor	Endostatin	22339(Tax:10090)	12822(Tax:10090)	Gene	Gene	secretion|compound|START_ENTITY induces|dobj|secretion induces|nsubj|transfer transfer|compound|END_ENTITY	Endostatin gene transfer in murine lung_carcinoma cells induces vascular_endothelial_growth_factor secretion resulting in up-regulation of in vivo tumorigenecity .
16410224	0	vascular_endothelial_growth_factor	115,149	Endostatin	0,10	vascular endothelial growth factor	Endostatin	7422	80781	Gene	Gene	endostatin|nmod|START_ENTITY influence|nmod|endostatin cells|dep|influence cyclase|nmod|cells down-regulates|nsubj|cyclase down-regulates|dep|END_ENTITY	Endostatin down-regulates soluble guanylate cyclase -LRB- sGC -RRB- in endothelial cells in vivo : influence of endostatin on vascular_endothelial_growth_factor -LRB- VEGF -RRB- signaling .
10889466	0	vascular_endothelial_growth_factor	21,55	Endothelin-1	0,12	vascular endothelial growth factor	Endothelin-1	22339(Tax:10090)	13614(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|nsubj|END_ENTITY	Endothelin-1 induces vascular_endothelial_growth_factor synthesis in osteoblasts : involvement of p38 mitogen-activated protein kinase .
12023962	0	vascular_endothelial_growth_factor	21,55	Endothelin-1	0,12	vascular endothelial growth factor	Endothelin-1	7422	1906	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Endothelin-1 induces vascular_endothelial_growth_factor by increasing hypoxia-inducible_factor-1alpha in ovarian_carcinoma cells .
21174590	0	vascular_endothelial_growth_factor	27,61	Endothelin-1	0,12	vascular endothelial growth factor	Endothelin-1	7422	1906	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Endothelin-1 expression by vascular_endothelial_growth_factor in human umbilical vein endothelial cells and aortic smooth muscle cells .
11330643	0	vascular_endothelial_growth_factor	52,86	Epidermal_growth_factor	0,23	vascular endothelial growth factor	Epidermal growth factor	7422	1950	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Epidermal_growth_factor modulates the expression of vascular_endothelial_growth_factor in the human prostate .
22707988	0	vascular_endothelial_growth_factor	147,181	Erythropoietin	0,14	vascular endothelial growth factor	Erythropoietin	83785(Tax:10116)	24335(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY mediates|nmod|expression mediates|nsubj|END_ENTITY	Erythropoietin mediates neurobehavioral recovery and neurovascular remodeling following traumatic_brain_injury in rats by increasing expression of vascular_endothelial_growth_factor .
19429439	0	vascular_endothelial_growth_factor	58,92	Estrogen-related_receptor_alpha	0,31	vascular endothelial growth factor	Estrogen-related receptor alpha	7422	2101	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Estrogen-related_receptor_alpha induces the expression of vascular_endothelial_growth_factor in breast_cancer cells .
10329444	0	vascular_endothelial_growth_factor	78,112	FLT	149,152	vascular endothelial growth factor	FLT	7422	2321	Gene	Gene	vitro|nmod|START_ENTITY vitro|nmod|upregulation upregulation|nmod|END_ENTITY	Inhibition of hepatic stellate cell contraction during activation in vitro by vascular_endothelial_growth_factor in association with upregulation of FLT tyrosine kinase receptor family , FLT-1 .
10329444	0	vascular_endothelial_growth_factor	78,112	FLT-1	186,191	vascular endothelial growth factor	FLT-1	7422	2321	Gene	Gene	vitro|nmod|START_ENTITY family|amod|vitro activation|nmod|family stellate|nmod|activation stellate|xcomp|END_ENTITY	Inhibition of hepatic stellate cell contraction during activation in vitro by vascular_endothelial_growth_factor in association with upregulation of FLT tyrosine kinase receptor family , FLT-1 .
11026652	0	vascular_endothelial_growth_factor	14,48	FLT-1	91,96	vascular endothelial growth factor	FLT-1	7422	2321	Gene	Gene	activity|compound|START_ENTITY Inhibition|nmod|activity Inhibition|nmod|gene gene|compound|END_ENTITY	Inhibition of vascular_endothelial_growth_factor activity by transfection with the soluble FLT-1 gene .
12494887	0	vascular_endothelial_growth_factor	37,71	FLT-1	94,99	vascular endothelial growth factor	FLT-1	7422	2321	Gene	Gene	VEGFR-1|compound|START_ENTITY VEGFR-1|appos|END_ENTITY	Modulation of human NK cell lines by vascular_endothelial_growth_factor and receptor VEGFR-1 -LRB- FLT-1 -RRB- .
14674128	0	vascular_endothelial_growth_factor	49,83	FLT-1	138,143	vascular endothelial growth factor	FLT-1	7422	2321	Gene	Gene	activity|nmod|START_ENTITY Correlation|nmod|activity Correlation|dep|END_ENTITY	-LSB- Correlation between transcriptional activity of vascular_endothelial_growth_factor -LRB- VEFG -RRB- and transcriptional activity of its receptors -LRB- FLT-1 and FLK-1 -RRB- in low-grade squamous intraepithelial_lesions -LRB- LSIL -RRB- of uterine cervix -RSB- .
16269656	0	vascular_endothelial_growth_factor	8,42	FLT-1	90,95	vascular endothelial growth factor	FLT-1	7422	2321	Gene	Gene	receptor-1|compound|START_ENTITY mediates|nsubj|receptor-1 mediates|dobj|downregulation downregulation|nmod|END_ENTITY	Soluble vascular_endothelial_growth_factor receptor-1 -LRB- sFLT-1 -RRB- mediates downregulation of FLT-1 and prevents activated neutrophils from women with preeclampsia from additional migration by VEGF .
10541969	0	vascular_endothelial_growth_factor	34,68	FLT-1_and_KDR	87,100	vascular endothelial growth factor	FLT-1 and KDR	7422	2321;3791	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nsubj|expression	Melanoma-associated expression of vascular_endothelial_growth_factor and its receptors FLT-1_and_KDR .
15073283	0	vascular_endothelial_growth_factor	39,73	Fas_ligand	14,24	vascular endothelial growth factor	Fas ligand	7422	356	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of Fas_ligand expression by vascular_endothelial_growth_factor in endometrial stromal cells in vitro .
9647657	0	vascular_endothelial_growth_factor	43,77	Fibroblast_growth_factor-2	0,26	vascular endothelial growth factor	Fibroblast growth factor-2	22339(Tax:10090)	14173(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the endothelial cells of forming capillaries : an autocrine mechanism contributing to angiogenesis .
11204275	0	vascular_endothelial_growth_factor	54,88	Fibroblast_growth_factor_2	0,26	vascular endothelial growth factor	Fibroblast growth factor 2	7422	2247	Gene	Gene	START_ENTITY|nsubj|activation activation|amod|END_ENTITY	Fibroblast_growth_factor_2 activation of stromal cell vascular_endothelial_growth_factor expression and angiogenesis .
11723743	0	vascular_endothelial_growth_factor	14,48	Flk-1	106,111	vascular endothelial growth factor	Flk-1	7422	3791	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor KDR -LRB- kinase_domain-containing_receptor -RRB- / Flk-1 -LRB- fetal_liver_kinase-1 -RRB- as prognostic factors in human colorectal_cancer .
12378509	0	vascular_endothelial_growth_factor	18,52	Flk-1	64,69	vascular endothelial growth factor	Flk-1	7422	3791	Gene	Gene	receptor-2|compound|START_ENTITY Expression|nmod|receptor-2 Expression|dep|END_ENTITY	Expression of the vascular_endothelial_growth_factor receptor-2 / Flk-1 in breast_carcinomas : correlation with proliferation .
15111299	0	vascular_endothelial_growth_factor	4,38	Flk-1	81,86	vascular endothelial growth factor	Flk-1	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	Flt-1|amod|START_ENTITY modulates|nsubj|Flt-1 modulates|dobj|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
15681497	0	vascular_endothelial_growth_factor	33,67	Flk-1	83,88	vascular endothelial growth factor	Flk-1	7422	3791	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Enhanced bronchial expression of vascular_endothelial_growth_factor and receptors -LRB- Flk-1 and Flt-1 -RRB- in patients with chronic_obstructive_pulmonary_disease .
16394178	0	vascular_endothelial_growth_factor	18,52	Flk-1	69,74	vascular endothelial growth factor	Flk-1	7422	3791	Gene	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor END_ENTITY|nsubj|Regulation	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16786328	0	vascular_endothelial_growth_factor	36,70	Flk-1	88,93	vascular endothelial growth factor	Flk-1	7422	3791	Gene	Gene	localization|nmod|START_ENTITY END_ENTITY|nsubj|localization	Immunohistochemical localization of vascular_endothelial_growth_factor and its receptor Flk-1 in the amphibian developing principal and accessory olfactory system .
23250775	0	vascular_endothelial_growth_factor	54,88	Flk-1	149,154	vascular endothelial growth factor	Flk-1	7422	3791	Gene	Gene	analysis|nmod|START_ENTITY follow-up|nmod|analysis follow-up|appos|KDR KDR|compound|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
9442048	0	vascular_endothelial_growth_factor	24,58	Flk-1	70,75	vascular endothelial growth factor	Flk-1	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	mRNA|compound|START_ENTITY mRNA|compound|END_ENTITY	Two functional forms of vascular_endothelial_growth_factor receptor-2 / Flk-1 mRNA are expressed in normal rat retina .
9637783	0	vascular_endothelial_growth_factor	14,48	Flk-1	61,66	vascular endothelial growth factor	Flk-1	281572(Tax:9913)	407170(Tax:9913)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|expression expression|appos|END_ENTITY	Regulation of vascular_endothelial_growth_factor receptor-2 -LRB- Flk-1 -RRB- expression in vascular endothelial cells .
9892193	0	vascular_endothelial_growth_factor	50,84	Flk-1	95,100	vascular endothelial growth factor	Flk-1	7422	3791	Gene	Gene	receptor|compound|START_ENTITY inhibitor|nmod|receptor inhibitor|appos|KDR KDR|compound|END_ENTITY	SU5416 is a potent and selective inhibitor of the vascular_endothelial_growth_factor receptor -LRB- Flk-1 / KDR -RRB- that inhibits tyrosine kinase catalysis , tumor vascularization , and growth of multiple tumor types .
10554042	0	vascular_endothelial_growth_factor	121,155	Flt-1	114,119	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	synthesis|compound|START_ENTITY Fms-like_tyrosine_kinase-1|dep|synthesis Fms-like_tyrosine_kinase-1|appos|END_ENTITY	Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like_tyrosine_kinase-1 -LRB- Flt-1 -RRB- / vascular_endothelial_growth_factor receptor-1 synthesis and neoangiogenesis .
11294698	0	vascular_endothelial_growth_factor	42,76	Flt-1	87,92	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	receptor|compound|START_ENTITY Measurement|nmod|receptor Measurement|appos|END_ENTITY	Measurement of free and complexed soluble vascular_endothelial_growth_factor receptor , Flt-1 , in fluid samples : development and application of two new immunoassays .
11468554	0	vascular_endothelial_growth_factor	14,48	Flt-1	67,72	vascular endothelial growth factor	Flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of vascular_endothelial_growth_factor and its receptors Flt-1 and KDR/Flk -1 in chronic cyclosporine nephrotoxicity .
12454810	0	vascular_endothelial_growth_factor	14,48	Flt-1	95,100	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of vascular_endothelial_growth_factor , placental_growth_factor , and their receptors Flt-1 and KDR in human placenta under pathologic conditions .
12606384	0	vascular_endothelial_growth_factor	14,48	Flt-1	72,77	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	isoforms|compound|START_ENTITY Expression|nmod|isoforms END_ENTITY|nsubj|Expression	Expression of vascular_endothelial_growth_factor isoforms and receptors Flt-1 and KDR during the peri-implantation period in the mink , Mustela vison .
12910290	0	vascular_endothelial_growth_factor	44,78	Flt-1	14,19	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|receptors receptors|amod|END_ENTITY	Expression of Flt-1 and Flk-1 receptors for vascular_endothelial_growth_factor on tumor cells as a new prognostic criterion for locally advanced breast_cancer .
15192019	0	vascular_endothelial_growth_factor	96,130	Flt-1	149,154	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	transactivation|nmod|START_ENTITY promotes|nmod|transactivation promotes|xcomp|END_ENTITY	Endothelial_PAS_domain_protein_1 gene promotes angiogenesis through the transactivation of both vascular_endothelial_growth_factor and its receptor , Flt-1 .
15492987	0	vascular_endothelial_growth_factor	14,48	Flt-1	84,89	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	START_ENTITY|dep|-RSB- -RSB-|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
16210956	0	vascular_endothelial_growth_factor	16,50	Flt-1	61,66	vascular endothelial growth factor	Flt-1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Function of the vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 / KDR in the alloimmune response in vivo .
17031660	0	vascular_endothelial_growth_factor	20,54	Flt-1	100,105	vascular endothelial growth factor	Flt-1	100462897	100732326	Gene	Gene	expression|amod|START_ENTITY alterations|nmod|expression alterations|dep|END_ENTITY	Fast alterations of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and that of its receptors -LRB- Flt-1 , Flk-1 and Neuropilin -RRB- in the cochlea of guinea_pigs after moderate noise exposure .
17402857	0	vascular_endothelial_growth_factor	16,50	Flt-1	61,66	vascular endothelial growth factor	Flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 in rat hippocampus after transient forebrain_ischemia .
17409380	0	vascular_endothelial_growth_factor	16,50	Flt-1	61,66	vascular endothelial growth factor	Flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY receptors|nsubj|Upregulation receptors|dobj|END_ENTITY	Upregulation of vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 following acute spinal_cord_contusion in rats .
17651752	0	vascular_endothelial_growth_factor	27,61	Flt-1	73,78	vascular endothelial growth factor	Flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY Expression|nmod|receptors Expression|dep|END_ENTITY	Expression and function of vascular_endothelial_growth_factor receptors -LRB- Flt-1 and Flk-1 -RRB- in vascular adventitial fibroblasts .
17854994	0	vascular_endothelial_growth_factor	14,48	Flt-1	59,64	vascular endothelial growth factor	Flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	receptors|compound|START_ENTITY receptors|amod|END_ENTITY	Expression of vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 in embryonic rat forebrain .
18726395	0	vascular_endothelial_growth_factor	19,53	Flt-1	70,75	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	Screening|nmod|START_ENTITY receptor|nsubj|Screening receptor|dobj|domain domain|compound|END_ENTITY	Screening of human vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 domain and study on its biological activity .
21515041	0	vascular_endothelial_growth_factor	83,117	Flt-1	56,61	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	diagnosis|nmod|START_ENTITY biosensor|dep|diagnosis biosensor|appos|END_ENTITY	A new impedimetric biosensor utilizing VEGF receptor-1 -LRB- Flt-1 -RRB- : early diagnosis of vascular_endothelial_growth_factor in breast_cancer .
8058332	0	vascular_endothelial_growth_factor	97,131	Flt-1	173,178	vascular endothelial growth factor	Flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	liver|nmod|START_ENTITY cells|nmod|liver system|nmod|cells tyrosine|nsubj|system tyrosine|dobj|family family|dep|END_ENTITY	A new communication system between hepatocytes and sinusoidal endothelial cells in liver through vascular_endothelial_growth_factor and Flt tyrosine kinase receptor family -LRB- Flt-1 and KDR/Flk -1 -RRB- .
8822205	0	vascular_endothelial_growth_factor	102,136	Flt-1	0,5	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	related|nmod|START_ENTITY factor|acl:relcl|related receptor|nmod|factor receptor|nsubj|END_ENTITY	Flt-1 but not KDR/Flk -1 tyrosine kinase is a receptor for placenta growth factor , which is related to vascular_endothelial_growth_factor .
9452434	0	vascular_endothelial_growth_factor	77,111	Flt-1	144,149	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	domain|nmod|START_ENTITY Mapping|nmod|domain END_ENTITY|dep|Mapping	Mapping the charged residues in the second immunoglobulin-like domain of the vascular_endothelial_growth_factor / placenta_growth_factor receptor Flt-1 required for binding and structural stability .
9620838	0	vascular_endothelial_growth_factor	82,116	Flt-1	127,132	vascular endothelial growth factor	Flt-1	7422	2321	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular_endothelial_growth_factor receptor , Flt-1 .
10554042	0	vascular_endothelial_growth_factor	121,155	Fms-like_tyrosine_kinase-1	86,112	vascular endothelial growth factor	Fms-like tyrosine kinase-1	7422	2321	Gene	Gene	synthesis|compound|START_ENTITY END_ENTITY|dep|synthesis	Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like_tyrosine_kinase-1 -LRB- Flt-1 -RRB- / vascular_endothelial_growth_factor receptor-1 synthesis and neoangiogenesis .
12949227	0	vascular_endothelial_growth_factor	77,111	Focal_adhesion_kinase	0,21	vascular endothelial growth factor	Focal adhesion kinase	7422	5747	Gene	Gene	porcine|nmod|START_ENTITY porcine|nsubj|mediates mediates|amod|END_ENTITY	Focal_adhesion_kinase mediates porcine venular_hyperpermeability elicited by vascular_endothelial_growth_factor .
18974115	0	vascular_endothelial_growth_factor	35,69	FoxM1B	0,6	vascular endothelial growth factor	FoxM1B	7422	2305	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	FoxM1B transcriptionally regulates vascular_endothelial_growth_factor expression and promotes the angiogenesis and growth of glioma cells .
24730523	0	vascular_endothelial_growth_factor	71,105	G-protein_coupled_receptor_124	0,30	vascular endothelial growth factor	G-protein coupled receptor 124	7422	25960	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	G-protein_coupled_receptor_124 -LRB- GPR124 -RRB- in endothelial cells regulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced tumor angiogenesis .
17178724	0	vascular_endothelial_growth_factor	38,72	Gab1	24,28	vascular endothelial growth factor	Gab1	281572(Tax:9913)	540085(Tax:9913)	Gene	Gene	mediates|dobj|START_ENTITY mediates|nsubj|END_ENTITY	The scaffolding adapter Gab1 mediates vascular_endothelial_growth_factor signaling and is required for endothelial cell migration and capillary formation .
16183188	0	vascular_endothelial_growth_factor	17,51	GnRH	88,92	vascular endothelial growth factor	GnRH	7422	2796	Gene	Gene	concentrations|compound|START_ENTITY increased|nsubjpass|concentrations increased|nmod|cycles cycles|amod|END_ENTITY	Follicular fluid vascular_endothelial_growth_factor concentrations are increased during GnRH antagonist/FSH ovarian stimulation cycles .
18321491	0	vascular_endothelial_growth_factor	8,42	GnRH	61,65	vascular endothelial growth factor	GnRH	7422	2796	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Altered vascular_endothelial_growth_factor expression during GnRH antagonist protocol in women of reproductive age with normal baseline hormone profiles .
19509297	0	vascular_endothelial_growth_factor	16,50	HDAC4	0,5	vascular endothelial growth factor	HDAC4	7422	9759	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	HDAC4 represses vascular_endothelial_growth_factor expression in chondrosarcoma by modulating RUNX2 activity .
15001987	0	vascular_endothelial_growth_factor	42,76	Heparin_affin_regulatory_peptide	0,32	vascular endothelial growth factor	Heparin affin regulatory peptide	7422	5764	Gene	Gene	binds|nmod|START_ENTITY binds|nsubj|END_ENTITY	Heparin_affin_regulatory_peptide binds to vascular_endothelial_growth_factor -LRB- VEGF -RRB- and inhibits VEGF-induced angiogenesis .
11834731	0	vascular_endothelial_growth_factor	51,85	HuR	94,97	vascular endothelial growth factor	HuR	7422	1994	Gene	Gene	mRNA|compound|START_ENTITY mRNA|nmod|END_ENTITY	A 40-bp RNA element that mediates stabilization of vascular_endothelial_growth_factor mRNA by HuR .
16306087	0	vascular_endothelial_growth_factor	117,151	HuR	83,86	vascular endothelial growth factor	HuR	7422	1994	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Antagonistic functions of tetradecanoyl_phorbol_acetate-inducible-sequence 11b and HuR in the hormonal regulation of vascular_endothelial_growth_factor messenger ribonucleic acid stability by adrenocorticotropin .
9497373	0	vascular_endothelial_growth_factor	25,59	HuR	92,95	vascular endothelial growth factor	HuR	7422	1994	Gene	Gene	mRNA|compound|START_ENTITY stabilization|nmod|mRNA stabilization|nmod|END_ENTITY	Hypoxic stabilization of vascular_endothelial_growth_factor mRNA by the RNA-binding protein HuR .
18339868	0	vascular_endothelial_growth_factor	82,116	Hypoxia-inducible_factor-1	0,26	vascular endothelial growth factor	Hypoxia-inducible factor-1	7422	3091	Gene	Gene	inhibition|compound|START_ENTITY response|nmod|inhibition genes|nmod|response genes|amod|END_ENTITY	Hypoxia-inducible_factor-1 target genes as indicators of tumor vessel response to vascular_endothelial_growth_factor inhibition .
15265376	0	vascular_endothelial_growth_factor	55,89	Hypoxia-inducible_factor-1_alpha	0,32	vascular endothelial growth factor	Hypoxia-inducible factor-1 alpha	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY regulates|dobj|role regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor-1_alpha regulates the role of vascular_endothelial_growth_factor on pulmonary arteries of rats with hypoxia-induced pulmonary_hypertension .
21765015	0	vascular_endothelial_growth_factor	61,95	Hypoxia-inducible_factor-2a	0,27	vascular endothelial growth factor	Hypoxia-inducible factor-2a	22339(Tax:10090)	13819(Tax:10090)	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor-2a regulates GM-CSF-derived soluble vascular_endothelial_growth_factor receptor 1 production from macrophages and inhibits tumor growth and angiogenesis .
12499918	0	vascular_endothelial_growth_factor	37,71	Hypoxia-inducible_factor_1	0,26	vascular endothelial growth factor	Hypoxia-inducible factor 1	7422	3091	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Hypoxia-inducible_factor_1 regulates vascular_endothelial_growth_factor expression in human pancreatic_cancer .
15175080	0	vascular_endothelial_growth_factor	32,66	Hypoxia-inducible_factor_1alpha	0,31	vascular endothelial growth factor	Hypoxia-inducible factor 1alpha	7422	3091	Gene	Gene	axis|nsubj|START_ENTITY END_ENTITY|parataxis|axis	Hypoxia-inducible_factor_1alpha / vascular_endothelial_growth_factor axis in astrocytomas .
22379030	0	vascular_endothelial_growth_factor	40,74	IL-17A	0,6	vascular endothelial growth factor	IL-17A	7422	3605	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	IL-17A differentially regulates corneal vascular_endothelial_growth_factor -LRB- VEGF -RRB- - A and soluble VEGF receptor 1 expression and promotes corneal_angiogenesis_after_herpes_simplex_virus_infection .
12102661	0	vascular_endothelial_growth_factor	50,84	IL-4	0,4	vascular endothelial growth factor	IL-4	7422	3565	Gene	Gene	release|compound|START_ENTITY modulate|dobj|release modulate|nsubj|END_ENTITY	IL-4 and interferon-gamma differentially modulate vascular_endothelial_growth_factor release from normal human keratinocytes and fibroblasts .
23177780	0	vascular_endothelial_growth_factor	32,66	IL-6	0,4	vascular endothelial growth factor	IL-6	7422	3569	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	IL-6 promotes the expression of vascular_endothelial_growth_factor through the p38 signalling pathway in hypertrophied adenoids in children .
15217908	0	vascular_endothelial_growth_factor	16,50	IQGAP1	0,6	vascular endothelial growth factor	IQGAP1	83785(Tax:10116)	361598(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|appos|receptor	IQGAP1 , a novel vascular_endothelial_growth_factor receptor binding protein , is involved in reactive oxygen species -- dependent endothelial migration and proliferation .
17145808	0	vascular_endothelial_growth_factor	84,118	Id-1	30,34	vascular endothelial growth factor	Id-1	7422	3397	Gene	Gene	up-regulation|compound|START_ENTITY END_ENTITY|nmod|up-regulation	Regulation of angiogenesis by Id-1 through hypoxia-inducible_factor-1alpha-mediated vascular_endothelial_growth_factor up-regulation in hepatocellular_carcinoma .
17426247	0	vascular_endothelial_growth_factor	37,71	Inhibitor_of_DNA_binding_1	0,26	vascular endothelial growth factor	Inhibitor of DNA binding 1	7422	3397	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Inhibitor_of_DNA_binding_1 activates vascular_endothelial_growth_factor through enhancing the stability and activity of hypoxia-inducible_factor-1alpha .
10329259	0	vascular_endothelial_growth_factor	108,142	Insulin	0,7	vascular endothelial growth factor	Insulin	7422	3630	Gene	Gene	stimulates|nmod|START_ENTITY stimulates|nsubj|END_ENTITY	Insulin stimulates the growth and tube formation of human microvascular endothelial cells through autocrine vascular_endothelial_growth_factor .
10777488	0	vascular_endothelial_growth_factor	48,82	Insulin	0,7	vascular endothelial growth factor	Insulin	7422	3630	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	Insulin and insulin-like growth factor-I induce vascular_endothelial_growth_factor mRNA expression via different signaling pathways .
11232025	0	vascular_endothelial_growth_factor	21,55	Insulin	0,7	vascular endothelial growth factor	Insulin	7422	3630	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|compound|END_ENTITY	Insulin up-regulates vascular_endothelial_growth_factor and stabilizes its messengers in endometrial_adenocarcinoma cells .
14633819	0	vascular_endothelial_growth_factor	43,77	Insulin	0,7	vascular endothelial growth factor	Insulin	7422	3630	Gene	Gene	metalloproteinase-9|compound|START_ENTITY concentration|nmod|metalloproteinase-9 suppresses|dobj|concentration suppresses|nsubj|END_ENTITY	Insulin suppresses plasma concentration of vascular_endothelial_growth_factor and matrix metalloproteinase-9 .
15473891	0	vascular_endothelial_growth_factor	18,52	Insulin	0,7	vascular endothelial growth factor	Insulin	83785(Tax:10116)	3630	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Insulin activates vascular_endothelial_growth_factor in vascular smooth muscle cells : influence of nitric_oxide and of insulin resistance .
16713312	0	vascular_endothelial_growth_factor	39,73	Insulin-like_growth_factor-I	0,28	vascular endothelial growth factor	Insulin-like growth factor-I	7422	3479	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Insulin-like_growth_factor-I regulates vascular_endothelial_growth_factor secretion by human oviductal epithelial cells and stromal fibroblasts .
22494072	0	vascular_endothelial_growth_factor	56,90	Insulin-like_growth_factor_binding_protein-3	0,44	vascular endothelial growth factor	Insulin-like growth factor binding protein-3	22339(Tax:10090)	16009(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY suppresses|dobj|expression suppresses|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 suppresses vascular_endothelial_growth_factor expression and tumor angiogenesis in head_and_neck_squamous_cell_carcinoma .
17390208	0	vascular_endothelial_growth_factor	40,74	Interleukin-1	0,13	vascular endothelial growth factor	Interleukin-1	7422	3552	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-1 induces the expression of vascular_endothelial_growth_factor in human pericardial mesothelial cells .
16368150	0	vascular_endothelial_growth_factor	41,75	Interleukin-18	0,14	vascular endothelial growth factor	Interleukin-18	7422	3606	Gene	Gene	production|nmod|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	Interleukin-18 induces the production of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in rheumatoid_arthritis synovial fibroblasts via AP-1-dependent pathways .
10198191	0	vascular_endothelial_growth_factor	53,87	Interleukin-1_beta	0,18	vascular endothelial growth factor	Interleukin-1 beta	7422	3553	Gene	Gene	expression|nmod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Interleukin-1_beta upregulates cardiac expression of vascular_endothelial_growth_factor and its receptor KDR/flk -1 via activation of protein tyrosine kinases .
16006751	0	vascular_endothelial_growth_factor	61,95	Interleukin-1_receptor_antagonist	0,33	vascular endothelial growth factor	Interleukin-1 receptor antagonist	7422	3557	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Interleukin-1_receptor_antagonist inhibits the expression of vascular_endothelial_growth_factor in colorectal_carcinoma .
17071533	0	vascular_endothelial_growth_factor	28,62	Interleukin-1beta	0,17	vascular endothelial growth factor	Interleukin-1beta	7422	3553	Gene	Gene	secretion|amod|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Interleukin-1beta regulates vascular_endothelial_growth_factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts .
11149012	0	vascular_endothelial_growth_factor	51,85	Interleukin-4	0,13	vascular endothelial growth factor	Interleukin-4	7422	3565	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Interleukin-4 inhibits the increased production of vascular_endothelial_growth_factor by peripheral blood mononuclear cells in patients with inflammatory_bowel_disease .
11426961	0	vascular_endothelial_growth_factor	56,90	Interleukin-6	0,13	vascular endothelial growth factor	Interleukin-6	7422	3569	Gene	Gene	relationship|nmod|START_ENTITY END_ENTITY|dep|relationship	Interleukin-6 in cervical_cancer : the relationship with vascular_endothelial_growth_factor .
15153787	0	vascular_endothelial_growth_factor	24,58	Interleukin-6	0,13	vascular endothelial growth factor	Interleukin-6	7422	3569	Gene	Gene	increases|dobj|START_ENTITY increases|nsubj|END_ENTITY	Interleukin-6 increases vascular_endothelial_growth_factor and angiogenesis in gastric_carcinoma .
15688401	0	vascular_endothelial_growth_factor	52,86	Interleukin-6	0,13	vascular endothelial growth factor	Interleukin-6	22339(Tax:10090)	16193(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY induces|dobj|activation induces|nsubj|END_ENTITY	Interleukin-6 induces transcriptional activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1 .
23219526	0	vascular_endothelial_growth_factor	22,56	Interleukin-6	0,13	vascular endothelial growth factor	Interleukin-6	7422	3569	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin-6 induces vascular_endothelial_growth_factor expression and promotes angiogenesis through apoptosis_signal-regulating_kinase_1 in human osteosarcoma .
18307536	0	vascular_endothelial_growth_factor	24,58	Interleukin-8	0,13	vascular endothelial growth factor	Interleukin-8	7422	3576	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Interleukin-8 increases vascular_endothelial_growth_factor and neuropilin expression and stimulates ERK activation in human pancreatic_cancer .
8557680	0	vascular_endothelial_growth_factor	40,74	Interleukin_6	0,13	vascular endothelial growth factor	Interleukin 6	7422	3569	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Interleukin_6 induces the expression of vascular_endothelial_growth_factor .
20709526	0	vascular_endothelial_growth_factor	79,113	JAK3	155,159	vascular endothelial growth factor	JAK3	7422	3718	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	STAT3 activation induced by Epstein-Barr_virus latent membrane protein1 causes vascular_endothelial_growth_factor expression and cellular invasiveness via JAK3 And ERK signaling .
24136993	0	vascular_endothelial_growth_factor	48,82	JunB	8,12	vascular endothelial growth factor	JunB	22339(Tax:10090)	16477(Tax:10090)	Gene	Gene	production|compound|START_ENTITY Role|nmod|production Role|nmod|END_ENTITY	Role of JunB in adenosine A2B receptor-mediated vascular_endothelial_growth_factor production .
10799512	0	vascular_endothelial_growth_factor	97,131	KDR	62,65	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	antibodies|compound|START_ENTITY interaction|nmod|antibodies important|nmod|interaction Identification|amod|important Identification|nmod|residues residues|nmod|region region|nmod|END_ENTITY	Identification of the residues in the extracellular region of KDR important for interaction with vascular_endothelial_growth_factor and neutralizing anti-KDR antibodies .
12135291	0	vascular_endothelial_growth_factor	18,52	KDR	87,90	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Overexpression|nmod|START_ENTITY END_ENTITY|nsubj|Overexpression	Overexpression of vascular_endothelial_growth_factor and its endothelial cell receptor KDR in type 1 leprosy reaction .
12226078	0	vascular_endothelial_growth_factor	19,53	KDR	76,79	vascular endothelial growth factor	KDR	281572(Tax:9913)	407170(Tax:9913)	Gene	Gene	Flk-1|amod|START_ENTITY Transactivation|nmod|Flk-1 Transactivation|parataxis|involved involved|nsubjpass|END_ENTITY	Transactivation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR is involved in sphingosine_1-phosphate-stimulated phosphorylation of Akt and endothelial_nitric-oxide_synthase -LRB- eNOS -RRB- .
12439912	0	vascular_endothelial_growth_factor	14,48	KDR	67,70	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of vascular_endothelial_growth_factor and its receptors KDR and Flt-1 in gastric_cancer cells .
12859876	0	vascular_endothelial_growth_factor	15,49	KDR	68,71	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	-LSB- Expression of vascular_endothelial_growth_factor and its receptors KDR and Flt1 in acute_myeloid_leukemia -RSB- .
15946674	0	vascular_endothelial_growth_factor	102,136	KDR	157,160	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptor-2|compound|START_ENTITY receptor-2|appos|END_ENTITY	Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular_endothelial_growth_factor receptor-2 -LRB- VEGFR-2 / KDR -RRB- .
16210956	0	vascular_endothelial_growth_factor	16,50	KDR	77,80	vascular endothelial growth factor	KDR	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	receptors|compound|START_ENTITY Function|nmod|receptors Function|dep|END_ENTITY	Function of the vascular_endothelial_growth_factor receptors Flt-1 and Flk-1 / KDR in the alloimmune response in vivo .
16394178	0	vascular_endothelial_growth_factor	18,52	KDR	75,78	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor Flk-1|nsubj|Regulation Flk-1|dobj|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16556453	0	vascular_endothelial_growth_factor	12,46	KDR	70,73	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The role of vascular_endothelial_growth_factor and its receptor Flk-1 / KDR in promoting tumour angiogenesis in feline and canine mammary carcinomas : a preliminary study of autocrine and paracrine loops .
18763120	0	vascular_endothelial_growth_factor	16,50	KDR	68,71	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Coexpression|nmod|START_ENTITY END_ENTITY|nsubj|Coexpression	Coexpression of vascular_endothelial_growth_factor and its receptor KDR on gastric_adenocarcinoma MGC803 cell line and stimulation of exogenous VEGF -LRB- 165 -RRB- to MGC803 cells .
19218116	0	vascular_endothelial_growth_factor	15,49	KDR	73,76	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	-LSB- Expression of vascular_endothelial_growth_factor and its receptor Flk-1 / KDR in benign and malignant_breast_neoplasms -RSB- .
20538805	0	vascular_endothelial_growth_factor	10,44	KDR	62,65	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Effect|nmod|START_ENTITY END_ENTITY|nsubj|Effect	Effect of vascular_endothelial_growth_factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo .
23250775	0	vascular_endothelial_growth_factor	54,88	KDR	155,158	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	analysis|nmod|START_ENTITY follow-up|nmod|analysis follow-up|appos|END_ENTITY	Long-term follow-up of immunocytochemical analysis of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and its two receptors , VEGF-R1 -LRB- Flt-1 -RRB- and VEGF-R2 -LRB- Flk-1 / KDR -RRB- , in oesophagogastric_cancer .
23393131	0	vascular_endothelial_growth_factor	63,97	KDR	147,150	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	activation|amod|START_ENTITY activation|appos|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
7585655	0	vascular_endothelial_growth_factor	18,52	KDR	75,78	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor gene , KDR , in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation .
7664263	0	vascular_endothelial_growth_factor	14,48	KDR	67,70	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor , KDR , correlates with vascularity , metastasis , and proliferation of human colon_cancer .
7929268	1	vascular_endothelial_growth_factor	40,74	KDR	162,165	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	bioactivity|compound|START_ENTITY Potentiation|nmod|bioactivity END_ENTITY|dep|Potentiation	Potentiation of vascular_endothelial_growth_factor bioactivity , in vitro and in vivo , and high affinity binding to Flt-1 but not to Flk-1 / KDR .
7929439	0	vascular_endothelial_growth_factor	76,110	KDR	44,47	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptors|nmod|START_ENTITY properties|appos|receptors properties|nmod|END_ENTITY	Different signal transduction properties of KDR and Flt1 , two receptors for vascular_endothelial_growth_factor .
8621427	0	vascular_endothelial_growth_factor	18,52	KDR	78,81	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	Identification|nmod|START_ENTITY determinants|nsubj|Identification determinants|nmod|END_ENTITY	Identification of vascular_endothelial_growth_factor determinants for binding KDR and FLT-1 receptors .
8806634	0	vascular_endothelial_growth_factor	48,82	KDR	132,135	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY form|nmod|receptor Identification|nmod|form Identification|nmod|END_ENTITY	Identification of a natural soluble form of the vascular_endothelial_growth_factor receptor , FLT-1 , and its heterodimerization with KDR .
8840857	0	vascular_endothelial_growth_factor	31,65	KDR	75,78	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY upregulation|nmod|receptor END_ENTITY|nsubj|upregulation	Functional upregulation of the vascular_endothelial_growth_factor receptor KDR by hypoxia .
9732240	0	vascular_endothelial_growth_factor	14,48	KDR	58,61	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY Regulation|nmod|receptor END_ENTITY|nsubj|Regulation	Regulation of vascular_endothelial_growth_factor receptor KDR in vitro by a soluble factor in confluent endothelial cells .
9846628	0	vascular_endothelial_growth_factor	14,48	KDR	67,70	vascular endothelial growth factor	KDR	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor , KDR , following retinal_ischemia-reperfusion injury in the rat .
9889193	0	vascular_endothelial_growth_factor	8,42	KDR	127,130	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	encoded|nsubj|START_ENTITY encoded|nmod|Orf_virus Orf_virus|appos|angiogenesis angiogenesis|acl|signalling signalling|nmod|VEGFR-2 VEGFR-2|appos|END_ENTITY	A novel vascular_endothelial_growth_factor encoded by Orf_virus , VEGF-E , mediates angiogenesis via signalling through VEGFR-2 -LRB- KDR -RRB- but not VEGFR-1 -LRB- Flt-1 -RRB- receptor tyrosine kinases .
9892193	0	vascular_endothelial_growth_factor	50,84	KDR	101,104	vascular endothelial growth factor	KDR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY inhibitor|nmod|receptor inhibitor|appos|END_ENTITY	SU5416 is a potent and selective inhibitor of the vascular_endothelial_growth_factor receptor -LRB- Flk-1 / KDR -RRB- that inhibits tyrosine kinase catalysis , tumor vascularization , and growth of multiple tumor types .
12482580	0	vascular_endothelial_growth_factor	24,58	Kip2	79,83	vascular endothelial growth factor	Kip2	22339(Tax:10090)	12577(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Increased expression of vascular_endothelial_growth_factor in placentas of p57 -LRB- Kip2 -RRB- null embryos .
22864925	0	vascular_endothelial_growth_factor	72,106	LGALS3BP	0,8	vascular endothelial growth factor	LGALS3BP	7422	3959	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	LGALS3BP , lectin_galactoside-binding soluble 3 binding protein , induces vascular_endothelial_growth_factor in human breast_cancer cells and promotes angiogenesis .
26120271	0	vascular_endothelial_growth_factor	36,70	LRP6	9,13	vascular endothelial growth factor	LRP6	7422	4040	Gene	Gene	correlate|nmod|START_ENTITY correlate|nsubj|levels levels|compound|END_ENTITY	Elevated LRP6 levels correlate with vascular_endothelial_growth_factor in the vitreous of proliferative_diabetic_retinopathy .
12928417	0	vascular_endothelial_growth_factor	14,48	M-CSF	0,5	vascular endothelial growth factor	M-CSF	7422	1435	Gene	Gene	production|compound|START_ENTITY induces|dobj|production induces|nsubj|END_ENTITY	M-CSF induces vascular_endothelial_growth_factor production and angiogenic activity from human monocytes .
23780984	0	vascular_endothelial_growth_factor	142,176	MCT4	85,89	vascular endothelial growth factor	MCT4	7422	9122	Gene	Gene	contributes|nmod|START_ENTITY contributes|nsubj|END_ENTITY	Expression of monocarboxylate_transporter _ -LRB- MCT -RRB- -4 in colorectal_cancer and its role : MCT4 contributes to the growth of colorectal_cancer with vascular_endothelial_growth_factor .
21986500	0	vascular_endothelial_growth_factor	15,49	MDM2	0,4	vascular endothelial growth factor	MDM2	7422	4193	Gene	Gene	stabilization|compound|START_ENTITY regulates|dobj|stabilization regulates|nsubj|END_ENTITY	MDM2 regulates vascular_endothelial_growth_factor mRNA stabilization in hypoxia .
22472569	0	vascular_endothelial_growth_factor	21,55	MicroRNA-145	0,12	vascular endothelial growth factor	MicroRNA-145	7422	406937	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	MicroRNA-145 targets vascular_endothelial_growth_factor and inhibits invasion and metastasis of osteosarcoma cells .
17702744	0	vascular_endothelial_growth_factor	20,54	Myoferlin	0,9	vascular endothelial growth factor	Myoferlin	22339(Tax:10090)	226101(Tax:10090)	Gene	Gene	regulates|xcomp|START_ENTITY regulates|nsubj|END_ENTITY	Myoferlin regulates vascular_endothelial_growth_factor receptor-2 stability and function .
18454179	0	vascular_endothelial_growth_factor	73,107	NADPH_oxidase_1	0,15	vascular endothelial growth factor	NADPH oxidase 1	83785(Tax:10116)	114243(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY role|nmod|expression plays|dobj|role plays|nsubj|END_ENTITY	NADPH_oxidase_1 plays a critical mediating role in oncogenic Ras-induced vascular_endothelial_growth_factor expression .
27035511	0	vascular_endothelial_growth_factor	45,79	Nemo-like_kinase	0,16	vascular endothelial growth factor	Nemo-like kinase	22339(Tax:10090)	18099(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nemo-like_kinase regulates the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in alveolar epithelial cells .
16935322	0	vascular_endothelial_growth_factor	86,120	Nerve_growth_factor	0,19	vascular endothelial growth factor	Nerve growth factor	7422	4803	Gene	Gene	expression|compound|START_ENTITY control|nmod|expression participate|nmod|control participate|nsubj|END_ENTITY	Nerve_growth_factor and its high-affinity receptor trkA participate in the control of vascular_endothelial_growth_factor expression in epithelial_ovarian_cancer .
24615084	0	vascular_endothelial_growth_factor	48,82	Nerve_growth_factor	0,19	vascular endothelial growth factor	Nerve growth factor	7422	4803	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Nerve_growth_factor regulates the expression of vascular_endothelial_growth_factor in human HaCaT keratinocytes via PI3K/mTOR pathway .
11986311	0	vascular_endothelial_growth_factor	19,53	Neuropilin-1	0,12	vascular endothelial growth factor	Neuropilin-1	7422	8829	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Neuropilin-1 binds vascular_endothelial_growth_factor 165 , placenta growth factor-2 , and heparin via its b1b2 domain .
15522955	0	vascular_endothelial_growth_factor	78,112	Neuropilin-1	0,12	vascular endothelial growth factor	Neuropilin-1	7422	8829	Gene	Gene	receptor-2|compound|START_ENTITY cells|nmod|receptor-2 regulates|nmod|cells regulates|nsubj|END_ENTITY	Neuropilin-1 regulates attachment in human endothelial cells independently of vascular_endothelial_growth_factor receptor-2 .
19857463	0	vascular_endothelial_growth_factor	34,68	Neuropilin-1	0,12	vascular endothelial growth factor	Neuropilin-1	7422	8829	Gene	Gene	cells|amod|START_ENTITY complexes|nmod|cells forms|dobj|complexes forms|nsubj|END_ENTITY	Neuropilin-1 forms complexes with vascular_endothelial_growth_factor receptor-2 during megakaryocytic differentiation of UT-7 / TPO cells .
9529250	0	vascular_endothelial_growth_factor	93,127	Neuropilin-1	0,12	vascular endothelial growth factor	Neuropilin-1	7422	8829	Gene	Gene	receptor|nmod|START_ENTITY expressed|nmod|receptor expressed|nsubjpass|END_ENTITY	Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular_endothelial_growth_factor .
10748121	0	vascular_endothelial_growth_factor	35,69	Neuropilin-2	0,12	vascular endothelial growth factor	Neuropilin-2	7422	8828	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Neuropilin-2 is a receptor for the vascular_endothelial_growth_factor -LRB- VEGF -RRB- forms VEGF-145 and VEGF-165 -LSB- corrected -RSB- .
14603252	0	vascular_endothelial_growth_factor	26,60	Oncostatin-M	0,12	vascular endothelial growth factor	Oncostatin-M	7422	5008	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|amod|END_ENTITY	Oncostatin-M induction of vascular_endothelial_growth_factor expression in astroglioma cells .
15985268	0	vascular_endothelial_growth_factor	77,111	PEDF	35,39	vascular endothelial growth factor	PEDF	7422	57104	Gene	Gene	expression|amod|START_ENTITY apoptosis|nmod|expression Pigment_epithelium-derived_factor|dep|apoptosis Pigment_epithelium-derived_factor|appos|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16624340	0	vascular_endothelial_growth_factor	73,107	PEDF	35,39	vascular endothelial growth factor	PEDF	7422	5176	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|factor factor|appos|END_ENTITY	Pigment-epithelium-derived factor -LRB- PEDF -RRB- inhibits angiotensin-II-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MOLT-3 T cells through anti-oxidative properties .
25948043	0	vascular_endothelial_growth_factor	57,91	PEDF	46,50	vascular endothelial growth factor	PEDF	7422	57104	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	Recombinant pigment_epithelium-derived_factor PEDF binds vascular_endothelial_growth_factor receptors 1 and 2 .
22763125	0	vascular_endothelial_growth_factor	51,85	PTP-MEG2	21,29	vascular endothelial growth factor	PTP-MEG2	7422	5780	Gene	Gene	receptor|compound|START_ENTITY regulates|dobj|receptor regulates|nsubj|END_ENTITY	Tyrosine phosphatase PTP-MEG2 negatively regulates vascular_endothelial_growth_factor receptor signaling and function in endothelial cells .
24403062	0	vascular_endothelial_growth_factor	51,85	PTP4A3	34,40	vascular endothelial growth factor	PTP4A3	22339(Tax:10090)	19245(Tax:10090)	Gene	Gene	promotes|dobj|START_ENTITY promotes|dep|END_ENTITY	Protein-tyrosine_phosphatase_4A3 -LRB- PTP4A3 -RRB- promotes vascular_endothelial_growth_factor signaling and enables endothelial cell motility .
18550647	0	vascular_endothelial_growth_factor	51,85	Parathyroid_hormone-related_protein	0,35	vascular endothelial growth factor	Parathyroid hormone-related protein	22339(Tax:10090)	19227(Tax:10090)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Parathyroid_hormone-related_protein interacts with vascular_endothelial_growth_factor to promote fibrogenesis in the obstructed mouse kidney .
18651620	0	vascular_endothelial_growth_factor	106,140	Parathyroid_hormone-related_protein	0,35	vascular endothelial growth factor	Parathyroid hormone-related protein	7422	5744	Gene	Gene	receptor-2|compound|START_ENTITY activation|nmod|receptor-2 increases|nmod|activation increases|nsubj|END_ENTITY	Parathyroid_hormone-related_protein -LRB- 107-139 -RRB- increases human osteoblastic cell survival by activation of vascular_endothelial_growth_factor receptor-2 .
12612059	0	vascular_endothelial_growth_factor	96,130	Phosphatidylinositol_3-kinase	0,29	vascular endothelial growth factor	Phosphatidylinositol 3-kinase	7422	5293	Gene	Gene	synthesis|compound|START_ENTITY END_ENTITY|dep|synthesis	Phosphatidylinositol_3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular_endothelial_growth_factor synthesis in prostate epithelial cells : a role for hypoxia-inducible factor-1 ?
12711260	0	vascular_endothelial_growth_factor	86,120	Pigment_epithelium-derived_factor	0,33	vascular endothelial growth factor	Pigment epithelium-derived factor	7422	57104	Gene	Gene	expression|compound|START_ENTITY suppressing|dobj|expression inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	Pigment_epithelium-derived_factor inhibits leptin-induced angiogenesis by suppressing vascular_endothelial_growth_factor gene expression through anti-oxidative properties .
15985268	0	vascular_endothelial_growth_factor	77,111	Pigment_epithelium-derived_factor	0,33	vascular endothelial growth factor	Pigment epithelium-derived factor	7422	57104	Gene	Gene	expression|amod|START_ENTITY apoptosis|nmod|expression END_ENTITY|dep|apoptosis	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16707486	0	vascular_endothelial_growth_factor	162,196	Pigment_epithelium-derived_factor	0,33	vascular endothelial growth factor	Pigment epithelium-derived factor	83785(Tax:10116)	287526(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY blocking|dobj|expression inhibits|advcl|blocking inhibits|nsubj|END_ENTITY	Pigment_epithelium-derived_factor inhibits advanced glycation end product-induced retinal_vascular_hyperpermeability by blocking reactive oxygen species-mediated vascular_endothelial_growth_factor expression .
18294451	0	vascular_endothelial_growth_factor	13,47	Pin1	77,81	vascular endothelial growth factor	Pin1	7422	5300	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by peptidyl-prolyl isomerase Pin1 in breast_cancer cells .
7478581	0	vascular_endothelial_growth_factor	16,50	PlGF	104,108	vascular endothelial growth factor	PlGF	7422	5228	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|appos|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and downregulation of placenta_growth_factor -LRB- PlGF -RRB- associated with malignancy in human thyroid_tumors and cell lines .
10606981	0	vascular_endothelial_growth_factor	38,72	Placenta_growth_factor	0,22	vascular endothelial growth factor	Placenta growth factor	7422	5228	Gene	Gene	secretion|amod|START_ENTITY induces|dobj|secretion induces|nsubj|END_ENTITY	Placenta_growth_factor -LRB- PlGF -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid .
16650817	0	vascular_endothelial_growth_factor	40,74	Protease-activated_receptor-2	0,29	vascular endothelial growth factor	Protease-activated receptor-2	7422	2150	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Protease-activated_receptor-2 regulates vascular_endothelial_growth_factor expression in MDA-MB-231 cells via MAPK pathways .
22941376	0	vascular_endothelial_growth_factor	52,86	Protease-activated_receptor-2	0,29	vascular endothelial growth factor	Protease-activated receptor-2	7422	2150	Gene	Gene	expression|nmod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Protease-activated_receptor-2 induces expression of vascular_endothelial_growth_factor and cyclooxygenase-2 via the mitogen-activated protein kinase pathway in gastric_cancer cells .
16443190	0	vascular_endothelial_growth_factor	10,44	RANK	48,52	vascular endothelial growth factor	RANK	7422	8792	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|expression expression|compound|END_ENTITY	Effect of vascular_endothelial_growth_factor on RANK gene expression in osteoclast precursors and on osteoclastogenesis .
20358644	0	vascular_endothelial_growth_factor	43,77	RON	4,7	vascular endothelial growth factor	RON	7422	4486	Gene	Gene	production|compound|START_ENTITY regulates|dobj|production regulates|nsubj|receptor receptor|compound|END_ENTITY	The RON tyrosine kinase receptor regulates vascular_endothelial_growth_factor production in pancreatic_cancer cells .
17085650	0	vascular_endothelial_growth_factor	33,67	RUNX3	0,5	vascular endothelial growth factor	RUNX3	7422	864	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	RUNX3 inhibits the expression of vascular_endothelial_growth_factor and reduces the angiogenesis , growth , and metastasis of human gastric_cancer .
23652833	0	vascular_endothelial_growth_factor	36,70	Resistin	0,8	vascular endothelial growth factor	Resistin	7422	56729	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Resistin promotes the expression of vascular_endothelial_growth_factor in ovary_carcinoma cells .
17203218	0	vascular_endothelial_growth_factor	138,172	S-1	0,3	vascular endothelial growth factor	S-1	22339(Tax:10090)	5707	Gene	Gene	expression|amod|START_ENTITY suppressing|dobj|expression inhibits|advcl|suppressing inhibits|nsubj|END_ENTITY	S-1 inhibits tumorigenicity and angiogenesis of human oral_squamous_cell_carcinoma cells by suppressing expression of phosphorylated Akt , vascular_endothelial_growth_factor and fibroblast_growth_factor-2 .
9792673	0	vascular_endothelial_growth_factor	60,94	SPARC	0,5	vascular endothelial growth factor	SPARC	7422	6678	Gene	Gene	effect|nmod|START_ENTITY inhibits|dobj|effect inhibits|nsubj|END_ENTITY	SPARC -LRB- BM-40 , osteonectin -RRB- inhibits the mitogenic effect of vascular_endothelial_growth_factor on microvascular endothelial cells .
17169602	0	vascular_endothelial_growth_factor	66,100	Signal_transducers_and_activators_of_transcription_3	0,52	vascular endothelial growth factor	Signal transducers and activators of transcription 3	7422	6774	Gene	Gene	START_ENTITY|nsubj|up-regulates up-regulates|amod|END_ENTITY	Signal_transducers_and_activators_of_transcription_3 up-regulates vascular_endothelial_growth_factor production and tumor angiogenesis in head_and_neck_squamous_cell_carcinoma .
11304689	0	vascular_endothelial_growth_factor	40,74	Somatostatin	0,12	vascular endothelial growth factor	Somatostatin	7422	6750	Gene	Gene	production|nmod|START_ENTITY inhibits|dobj|production inhibits|nsubj|END_ENTITY	Somatostatin inhibits the production of vascular_endothelial_growth_factor in human glioma cells .
12482909	0	vascular_endothelial_growth_factor	90,124	Sp1	10,13	vascular endothelial growth factor	Sp1	7422	6667	Gene	Gene	phosphorylation|dep|START_ENTITY phosphorylation|amod|END_ENTITY	Increased Sp1 phosphorylation as a mechanism of hepatocyte growth factor -LRB- HGF/SF -RRB- - induced vascular_endothelial_growth_factor -LRB- VEGF/VPF -RRB- transcription .
9271438	0	vascular_endothelial_growth_factor	82,116	Sp1	67,70	vascular endothelial growth factor	Sp1	32876(Tax:7227)	31913(Tax:7227)	Gene	Gene	activity|compound|START_ENTITY END_ENTITY|nmod|activity	The von_Hippel-Lindau_tumor_suppressor_gene product interacts with Sp1 to repress vascular_endothelial_growth_factor promoter activity .
11696015	0	vascular_endothelial_growth_factor	28,62	Src	0,3	vascular endothelial growth factor	Src	7422	6714	Gene	Gene	mediates|nmod|START_ENTITY mediates|nsubj|END_ENTITY	Src mediates stimulation by vascular_endothelial_growth_factor of the phosphorylation of focal_adhesion_kinase at tyrosine 861 , and migration and anti-apoptosis in endothelial cells .
16054437	0	vascular_endothelial_growth_factor	56,90	Src	14,17	vascular endothelial growth factor	Src	7422	20779(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY kinase|nmod|expression kinase|nsubj|Inhibition Inhibition|nmod|END_ENTITY	Inhibition of Src kinase activity by Ad-mda7 suppresses vascular_endothelial_growth_factor expression in prostate_carcinoma cells .
16909109	0	vascular_endothelial_growth_factor	71,105	Src	0,3	vascular endothelial growth factor	Src	7422	6714	Gene	Gene	response|nmod|START_ENTITY endothelial-cadherin|nmod|response phosphorylates|dobj|endothelial-cadherin phosphorylates|nsubj|kinase kinase|compound|END_ENTITY	Src kinase phosphorylates vascular endothelial-cadherin in response to vascular_endothelial_growth_factor : identification of tyrosine 685 as the unique target site .
9933439	0	vascular_endothelial_growth_factor	88,122	TGF-beta	60,68	vascular endothelial growth factor	TGF-beta	7422	7040	Gene	Gene	cytokine|dep|START_ENTITY cytokine|dep|END_ENTITY	Hypoxia augments cytokine -LRB- transforming_growth_factor-beta -LRB- TGF-beta -RRB- and IL-1 -RRB- - induced vascular_endothelial_growth_factor secretion by human synovial fibroblasts .
19836147	0	vascular_endothelial_growth_factor	14,48	TGFbeta3	164,172	vascular endothelial growth factor	TGFbeta3	7422	7043	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- , hypoxia_inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- , and transforming growth factors beta1 -LRB- TGFbeta1 -RRB- and beta3 -LRB- TGFbeta3 -RRB- in gestational_trophoblastic_disease .
12957716	0	vascular_endothelial_growth_factor	21,55	THP-1	85,90	vascular endothelial growth factor	THP-1	7422	2736	Gene	Gene	expression|compound|START_ENTITY expression|nmod|macrophages macrophages|compound|END_ENTITY	Homocysteine induces vascular_endothelial_growth_factor expression in differentiated THP-1 macrophages .
19446005	0	vascular_endothelial_growth_factor	21,55	TRPC1	89,94	vascular endothelial growth factor	TRPC1	7422	7220	Gene	Gene	START_ENTITY|dep|involvement involvement|nmod|END_ENTITY	Hypoxia up-regulates vascular_endothelial_growth_factor in U-87 MG cells : involvement of TRPC1 .
15705785	0	vascular_endothelial_growth_factor	38,72	Thrombopoietin	0,14	vascular endothelial growth factor	Thrombopoietin	22339(Tax:10090)	21832(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Thrombopoietin enhances expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in primitive hematopoietic cells through induction of HIF-1alpha .
11856116	0	vascular_endothelial_growth_factor	18,52	Thrombospondin-1	0,16	vascular endothelial growth factor	Thrombospondin-1	7422	7057	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Thrombospondin-1 , vascular_endothelial_growth_factor expression and their relationship with p53 status in_prostate_cancer and benign_prostatic_hyperplasia .
12814678	0	vascular_endothelial_growth_factor	18,52	Thrombospondin-1	0,16	vascular endothelial growth factor	Thrombospondin-1	7422	7057	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|appos|expression	Thrombospondin-1 , vascular_endothelial_growth_factor expression and microvessel density in renal_cell_carcinoma and their relationship with multifocality .
19528255	0	vascular_endothelial_growth_factor	27,61	Thrombospondin-1	0,16	vascular endothelial growth factor	Thrombospondin-1	22339(Tax:10090)	21825(Tax:10090)	Gene	Gene	activity|compound|START_ENTITY modulates|dobj|activity modulates|nsubj|END_ENTITY	Thrombospondin-1 modulates vascular_endothelial_growth_factor activity at the receptor level .
17023682	0	vascular_endothelial_growth_factor	52,86	Tissue_factor_pathway_inhibitor-2	0,33	vascular endothelial growth factor	Tissue factor pathway inhibitor-2	7422	7980	Gene	Gene	upregulated|nmod|START_ENTITY upregulated|nsubjpass|END_ENTITY	Tissue_factor_pathway_inhibitor-2 is upregulated by vascular_endothelial_growth_factor and suppresses growth factor-induced proliferation of endothelial cells .
14566975	0	vascular_endothelial_growth_factor	54,88	Transforming_growth_factor-beta	0,31	vascular endothelial growth factor	Transforming growth factor-beta	7422	7040	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Transforming_growth_factor-beta induces expression of vascular_endothelial_growth_factor in human retinal pigment epithelial cells : involvement of mitogen-activated protein kinases .
10516092	0	vascular_endothelial_growth_factor	61,95	Transforming_growth_factor-beta1	0,32	vascular endothelial growth factor	Transforming growth factor-beta1	83785(Tax:10116)	59086(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	Transforming_growth_factor-beta1 modulates the expression of vascular_endothelial_growth_factor by osteoblasts .
10971326	0	vascular_endothelial_growth_factor	85,119	Transforming_growth_factor-beta1	0,32	vascular endothelial growth factor	Transforming growth factor-beta1	7422	7040	Gene	Gene	production|nmod|START_ENTITY increase|dobj|production increase|nsubj|END_ENTITY	Transforming_growth_factor-beta1 and ultraviolet A1 radiation increase production of vascular_endothelial_growth_factor but not endothelin-1 in human dermal fibroblasts .
15143069	0	vascular_endothelial_growth_factor	44,78	Transforming_growth_factor-beta1	0,32	vascular endothelial growth factor	Transforming growth factor-beta1	22339(Tax:10090)	21803(Tax:10090)	Gene	Gene	164|compound|START_ENTITY 164|amod|END_ENTITY	Transforming_growth_factor-beta1 stimulates vascular_endothelial_growth_factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells .
18023419	0	vascular_endothelial_growth_factor	42,76	Transforming_growth_factor-beta1	0,32	vascular endothelial growth factor	Transforming growth factor-beta1	7422	7040	Gene	Gene	synthesis|compound|START_ENTITY synthesis|amod|END_ENTITY	Transforming_growth_factor-beta1 enhanced vascular_endothelial_growth_factor synthesis in mesenchymal stem cells .
14610327	0	vascular_endothelial_growth_factor	42,76	Transforming_growth_factor-beta_1	0,33	vascular endothelial growth factor	Transforming growth factor-beta 1	22339(Tax:10090)	21803(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 induces vascular_endothelial_growth_factor expression in murine proximal tubular epithelial cells .
19180561	0	vascular_endothelial_growth_factor	75,109	Transforming_growth_factor-beta_1	0,33	vascular endothelial growth factor	Transforming growth factor-beta 1	7422	7040	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Transforming_growth_factor-beta_1 -LRB- TGF-beta1 -RRB- induces angiogenesis through vascular_endothelial_growth_factor -LRB- VEGF -RRB- - mediated apoptosis .
16618748	0	vascular_endothelial_growth_factor	61,95	TrkB	48,52	vascular endothelial growth factor	TrkB	7422	4915	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|activation activation|nmod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
12208766	0	vascular_endothelial_growth_factor	144,178	Trx-1	102,107	vascular endothelial growth factor	Trx-1	7422	7295	Gene	Gene	production|compound|START_ENTITY results|nmod|production results|compound|END_ENTITY	The redox protein thioredoxin-1 -LRB- Trx-1 -RRB- increases hypoxia-inducible factor 1alpha protein expression : Trx-1 overexpression results in increased vascular_endothelial_growth_factor production and enhanced tumor angiogenesis .
17084400	0	vascular_endothelial_growth_factor	38,72	Tumor_necrosis_factor-alpha	0,27	vascular endothelial growth factor	Tumor necrosis factor-alpha	7422	7124	Gene	Gene	secretion|compound|START_ENTITY regulates|dobj|secretion regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates vascular_endothelial_growth_factor secretion by human oviductal epithelial cells and stromal fibroblasts .
21740086	0	vascular_endothelial_growth_factor	62,96	Tumor_necrosis_factor-alpha	0,27	vascular endothelial growth factor	Tumor necrosis factor-alpha	7422	7124	Gene	Gene	inducing|dobj|START_ENTITY promotes|advcl|inducing promotes|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha promotes tumor growth by inducing vascular_endothelial_growth_factor .
10408392	0	vascular_endothelial_growth_factor	94,128	VEGF	130,134	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- mRNA in cervical_cancer cell lines .
10452500	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in human thyroid_neoplasms .
10454244	0	vascular_endothelial_growth_factor	51,85	VEGF	87,91	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Progestins suppress estrogen-induced expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- subtypes in uterine endometrial_cancer cells .
10674116	0	vascular_endothelial_growth_factor	74,108	VEGF	110,114	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	-LSB- Therapeutic angiogenesis through intramuscular injection of the gene for vascular_endothelial_growth_factor -LRB- VEGF -RRB- -RSB- .
10801078	0	vascular_endothelial_growth_factor	12,46	VEGF	48,52	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in abnormal vascular changes in the adult rat eye .
10804088	0	vascular_endothelial_growth_factor	12,46	VEGF	48,52	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in AIDS-related Kaposi 's _ sarcoma .
10930302	0	vascular_endothelial_growth_factor	43,77	VEGF	79,83	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Identification of polymorphisms within the vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene : correlation with variation in VEGF protein production .
10952783	0	vascular_endothelial_growth_factor	20,54	VEGF	56,60	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic value of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in head and neck squamous_cell_carcinomas .
10954034	0	vascular_endothelial_growth_factor	8,42	VEGF	44,48	vascular endothelial growth factor	VEGF	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in endothelial cell protection against cytotoxic agents .
10995484	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene transcription by estrogen receptors alpha and beta .
11188930	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- as a novel approach for cancer therapy .
11261591	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Postnatal changes of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the retinae of normal and hypertensive rats .
11286562	0	vascular_endothelial_growth_factor	28,62	VEGF	64,68	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Developmental expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors and VEGF binding in ovine placenta and fetal membranes .
11299827	0	vascular_endothelial_growth_factor	30,64	VEGF	77,81	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Microvessel density -LRB- MVD -RRB- and vascular_endothelial_growth_factor expression -LRB- VEGF -RRB- in human oral_squamous_cell_carcinoma .
11344490	0	vascular_endothelial_growth_factor	17,51	VEGF	53,57	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Concentration|nmod|START_ENTITY Concentration|appos|END_ENTITY	Concentration of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the serum of patients with malignant_bone_tumors .
11423976	0	vascular_endothelial_growth_factor	29,63	VEGF	65,69	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Ionizing radiation modulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression through multiple mitogen activated protein kinase dependent pathways .
11571674	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Peripheral levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- are higher in gonadotropin stimulated as compared to natural ovarian cycles .
11578859	0	vascular_endothelial_growth_factor	12,46	VEGF	48,52	vascular endothelial growth factor	VEGF	30682(Tax:7955)	30682(Tax:7955)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in vasculogenesis , angiogenesis , and hematopoiesis in zebrafish development .
11732982	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors in rat corpus luteum : regulation by oestradiol during mid-pregnancy .
11777931	0	vascular_endothelial_growth_factor	46,80	VEGF	82,86	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Paracrine and autocrine functions of neuronal vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the central nervous system .
11827068	0	vascular_endothelial_growth_factor	15,49	VEGF	51,55	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Differences of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression between liver and abdominal metastases from colon_cancer .
11896832	0	vascular_endothelial_growth_factor	19,53	VEGF	55,59	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Salivary levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in recurrent aphthous ulceration .
11970755	0	vascular_endothelial_growth_factor	12,46	VEGF	48,52	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in tumor angiogenesis and early clinical development of VEGF-receptor kinase inhibitors .
11973650	0	vascular_endothelial_growth_factor	23,57	VEGF	59,63	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Enhanced expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- plays a critical role in the tumor progression potential induced by simian_virus_40 large T antigen .
12163680	0	vascular_endothelial_growth_factor	19,53	VEGF	55,59	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Green tea inhibits vascular_endothelial_growth_factor -LRB- VEGF -RRB- induction in human breast_cancer cells .
12228014	0	vascular_endothelial_growth_factor	7,41	VEGF	43,47	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Plasma vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA .
12411422	0	vascular_endothelial_growth_factor	24,58	VEGF	60,64	vascular endothelial growth factor	VEGF	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	mechanism|nmod|START_ENTITY mechanism|appos|END_ENTITY	Inhibitory mechanism of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by bucillamine .
12445161	0	vascular_endothelial_growth_factor	95,129	VEGF	131,135	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Macrophage_migration_inhibitory_factor -LRB- MIF -RRB- expression in human glioblastomas correlates with vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
12476614	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in human thyroid_tumors .
12497000	0	vascular_endothelial_growth_factor	16,50	VEGF	52,56	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in prostate_disease .
12668286	0	vascular_endothelial_growth_factor	32,66	VEGF	68,72	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	The significance of circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in gastric_cancer .
12684411	0	vascular_endothelial_growth_factor	18,52	VEGF	54,58	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of soluble vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor 1 in astrocytic_tumors and its relation to malignancy , vascularity , and VEGF-A .
12839674	0	vascular_endothelial_growth_factor	15,49	VEGF	51,55	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	-LSB- Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- C and VEGF receptor 3 in non-small_cell_lung_cancer -RSB- .
12871881	0	vascular_endothelial_growth_factor	10,44	VEGF	46,50	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Levels|nmod|START_ENTITY Levels|appos|END_ENTITY	Levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in serum of patients with endometriosis .
12917032	0	vascular_endothelial_growth_factor	9,43	VEGF	45,49	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	-LSB- Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in development and progress of refractory acute_myeloid_leukemia -RSB- .
12924491	0	vascular_endothelial_growth_factor	52,86	VEGF	88,92	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Effects of oxygen administration on the circulating vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in patients with obstructive_sleep_apnea_syndrome .
14518267	0	vascular_endothelial_growth_factor	18,52	VEGF	54,58	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	-LSB- Determination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- concentration in serum of patients with colorectal_carcinoma -RSB- .
14600832	0	vascular_endothelial_growth_factor	17,51	VEGF	53,57	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Determination|nmod|START_ENTITY Determination|appos|END_ENTITY	Determination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- overexpression in soft tissue sarcomas and the role of overexpression in leiomyosarcoma .
14666713	0	vascular_endothelial_growth_factor	37,71	VEGF	73,77	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	determination|nmod|START_ENTITY determination|appos|END_ENTITY	Immunohistochemical determination of vascular_endothelial_growth_factor -LRB- VEGF -RRB- overexpression in malignant_melanoma .
14746189	0	vascular_endothelial_growth_factor	13,47	VEGF	49,53	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	-LSB- The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- -RSB- .
14990072	0	vascular_endothelial_growth_factor	59,93	VEGF	1,5	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	-LSB- VEGF antisense oligonucleotide inhibits the expression of vascular_endothelial_growth_factor in human leukemic cell lines -RSB- .
15050460	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Umbilical cord serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in normal pregnancies and in pregnancies complicated by preterm_delivery or pre-eclampsia .
15053061	0	vascular_endothelial_growth_factor	11,45	VEGF	47,51	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in vascular_endothelial_growth_factor -LRB- VEGF -RRB- after chemoendocrine therapy in breast_cancer .
15066146	0	vascular_endothelial_growth_factor	27,61	VEGF	63,67	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Neuroprotective effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- upon dopaminergic neurons in a rat model of Parkinson 's _ disease .
15111299	0	vascular_endothelial_growth_factor	4,38	VEGF	40,44	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Flt-1|amod|START_ENTITY Flt-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
15149314	0	vascular_endothelial_growth_factor	12,46	VEGF	48,52	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in renal pathophysiology .
15157322	0	vascular_endothelial_growth_factor	22,56	VEGF	58,62	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- Inhibiting effect of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotides on VEGF expression in U937 cell -RSB- .
15200265	0	vascular_endothelial_growth_factor	28,62	VEGF	64,68	vascular endothelial growth factor	VEGF	403802(Tax:9615)	403802(Tax:9615)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	Preliminary study of plasma vascular_endothelial_growth_factor -LRB- VEGF -RRB- during low - and high-dose radiation therapy of dogs with spontaneous tumors .
15350962	0	vascular_endothelial_growth_factor	11,45	VEGF	47,51	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on motor neuron_degeneration .
15583935	0	vascular_endothelial_growth_factor	127,161	VEGF	163,167	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Anti-angiogenic effects of SN38 -LRB- active metabolite of irinotecan -RRB- : inhibition of hypoxia-inducible_factor_1_alpha -LRB- HIF-1alpha -RRB- / vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression of glioma and growth of endothelial cells .
15646494	1	vascular_endothelial_growth_factor	46,80	VEGF	82,86	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- -RSB- .
15673292	0	vascular_endothelial_growth_factor	37,71	VEGF	73,77	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	functions|nmod|START_ENTITY functions|appos|END_ENTITY	Autocrine and paracrine functions of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in renal tubular epithelial cells .
15702434	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- does not affect early renal changes in a rat model of lean type 2 diabetes .
15716999	0	vascular_endothelial_growth_factor	25,59	VEGF	61,65	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in sera of patients with pediatric_malignancies .
15760668	0	vascular_endothelial_growth_factor	36,70	VEGF	72,76	vascular endothelial growth factor	VEGF	397157(Tax:9823)	397157(Tax:9823)	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Fasting influences steroidogenesis , vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels and mRNAs expression for VEGF , VEGF receptor type 2 -LRB- VEGFR-2 -RRB- , endothelin-1 -LRB- ET-1 -RRB- , endothelin_receptor_type_A -LRB- ET-A -RRB- and endothelin_converting_enzyme-1 -LRB- ECE-1 -RRB- in newly formed pig corpora lutea .
15921007	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in vulvar_squamous_cancer and VIN .
15985268	0	vascular_endothelial_growth_factor	77,111	VEGF	113,117	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Pigment_epithelium-derived_factor -LRB- PEDF -RRB- - induced apoptosis and inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in MG63 human osteosarcoma cells .
16144770	0	vascular_endothelial_growth_factor	12,46	VEGF	48,52	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in oral_dysplasia and oral_squamous_cell_carcinoma .
16267616	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Activation|nmod|START_ENTITY Activation|appos|END_ENTITY	Activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by the ER-alpha variant , ERDelta3 .
16394178	0	vascular_endothelial_growth_factor	18,52	VEGF	54,58	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Regulation of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flk-1 / KDR by estradiol through VEGF in uterus .
16468311	0	vascular_endothelial_growth_factor	24,58	VEGF	60,64	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	-LSB- Targeted inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human osteosarcoma cell line by antisense VEGF165 cDNA promoted by hypoxia reaction element -RSB- .
16496371	0	vascular_endothelial_growth_factor	86,120	VEGF	122,126	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Correlations of oral_tongue_cancer invasion with matrix metalloproteinases -LRB- MMPs -RRB- and vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
16801663	0	vascular_endothelial_growth_factor	41,75	VEGF	77,81	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Possible gender-dependent association of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene and ALS .
16835467	0	vascular_endothelial_growth_factor	24,58	VEGF	60,64	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Signal transduction via vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors and their roles in atherogenesis .
16954806	0	vascular_endothelial_growth_factor	12,46	VEGF	48,52	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in inflammatory_bowel_disease .
16981238	0	vascular_endothelial_growth_factor	28,62	VEGF	64,68	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	induction|nmod|START_ENTITY induction|appos|END_ENTITY	TLR-2-mediated induction of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in cartilage in septic_joint_disease .
17031660	0	vascular_endothelial_growth_factor	20,54	VEGF	56,60	vascular endothelial growth factor	VEGF	100462897	100462897	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fast alterations of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and that of its receptors -LRB- Flt-1 , Flk-1 and Neuropilin -RRB- in the cochlea of guinea_pigs after moderate noise exposure .
17065408	0	vascular_endothelial_growth_factor	16,50	VEGF	52,56	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Localization of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors in normal and adenomatous_pituitaries : detection of a non-endothelial function of VEGF in pituitary_tumours .
17070126	0	vascular_endothelial_growth_factor	96,130	VEGF	132,136	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Growth and differentiation factor-5 -LRB- GDF-5 -RRB- stimulates osteogenic differentiation and increases vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels in fat-derived stromal cells in vitro .
17127464	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of vascular_endothelial_growth_factor , VEGF , gene promoter by the tumor suppressor , WT1 .
17141472	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in normal oral mucosa , oral_dysplasia and oral_squamous_cell_carcinoma .
17275223	0	vascular_endothelial_growth_factor	39,73	VEGF	75,79	vascular endothelial growth factor	VEGF	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Progesterone induces the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- 120 and Flk-1 , its receptor , in bovine granulosa cells .
17683807	0	vascular_endothelial_growth_factor	46,80	VEGF	82,86	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Vasoactive intestinal peptide -LRB- VIP -RRB- increases vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and secretion in human breast_cancer cells .
17822316	0	vascular_endothelial_growth_factor	34,68	VEGF	70,74	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- does not correlate with microvessel density in renal_cell_carcinoma .
18273500	0	vascular_endothelial_growth_factor	34,68	VEGF	70,74	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in intestinal type gastric_carcinoma .
18301455	0	vascular_endothelial_growth_factor	34,68	VEGF	70,74	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	evaluation|nmod|START_ENTITY evaluation|appos|END_ENTITY	Immunohistochemical evaluation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in colorectal_carcinoma .
18317965	0	vascular_endothelial_growth_factor	6,40	VEGF	42,46	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels correlate with tumor VEGF and p53 overexpression in endocrine positive primary breast_cancer .
18317965	0	vascular_endothelial_growth_factor	6,40	VEGF	76,80	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|compound|START_ENTITY correlate|nsubj|levels correlate|nmod|END_ENTITY	Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels correlate with tumor VEGF and p53 overexpression in endocrine positive primary breast_cancer .
18419602	0	vascular_endothelial_growth_factor	18,52	VEGF	54,58	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Overexpression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors on keratinocytes in psoriasis : regulated by calcium independent of VEGF .
18546007	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	system|amod|START_ENTITY system|appos|END_ENTITY	The clinical role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- system in the pathogenesis of retinopathy_of_prematurity .
19112107	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	CXCL8/IL8 stimulates vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM -LRB- Carma3/Bcl10/Malt1 -RRB- complex .
19486605	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	100860957	100860957	Gene	Gene	receptor|amod|START_ENTITY receptor|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor in goat ovaries and improvement of in vitro caprine preantral follicle survival and growth with VEGF .
19734078	0	vascular_endothelial_growth_factor	45,79	VEGF	81,85	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	Investigating the differential activation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors .
19764591	0	vascular_endothelial_growth_factor	37,71	VEGF	73,77	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	-LSB- Prognostic significance of cellular vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the course of chronic_myeloid_leukaemia -RSB- .
19834063	0	vascular_endothelial_growth_factor	35,69	VEGF	71,75	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of increased renal tubular vascular_endothelial_growth_factor -LRB- VEGF -RRB- on fibrosis , cyst_formation , _ and_glomerular_disease .
19899967	0	vascular_endothelial_growth_factor	56,90	VEGF	92,96	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effect of zeaxanthin and antioxidant supplementation on vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in apolipoprotein-E deficient mice .
19967101	0	vascular_endothelial_growth_factor	13,47	VEGF	49,53	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on gastroprotection in stress-induced gastric_mucosal_ulcers in rats .
20156197	0	vascular_endothelial_growth_factor	16,50	VEGF	10,14	vascular endothelial growth factor	VEGF	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|END_ENTITY	Effect of VEGF -LRB- vascular_endothelial_growth_factor -RRB- on expression of IL-8 -LRB- interleukin-8 -RRB- , IL-1beta and their receptors in bovine theca cells .
20417686	0	vascular_endothelial_growth_factor	24,58	VEGF	60,64	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	Direct survival role of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on rat ovarian follicular cells .
20563616	0	vascular_endothelial_growth_factor	34,68	VEGF	70,74	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in different types_of_odontogenic_cysts .
20819828	0	vascular_endothelial_growth_factor	6,40	VEGF	42,46	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- levels correlate with number and location of micrometastases in a murine model of uveal_melanoma .
20976598	0	vascular_endothelial_growth_factor	46,80	VEGF	82,86	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Microencapsulated myoblasts transduced by the vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene for the ischemic skin flap .
21040465	0	vascular_endothelial_growth_factor	11,45	VEGF	47,51	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on MC3T3-E1 .
21273213	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	281572(Tax:9913)	281572(Tax:9913)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- is sufficient to completely restore barrier malfunction induced by growth factors in microvascular retinal endothelial cells .
21378364	0	vascular_endothelial_growth_factor	18,52	VEGF	54,58	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene in epithelial_ovarian_cancer : an approach to anti-VEGF therapy .
21487788	0	vascular_endothelial_growth_factor	8,42	VEGF	126,130	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	inhibits|nsubj|START_ENTITY inhibits|nmod|END_ENTITY	Soluble vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-1 inhibits migration of human monocytic THP-1 cells in response to VEGF .
21696760	0	vascular_endothelial_growth_factor	35,69	VEGF	71,75	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	inhibition|nmod|START_ENTITY inhibition|appos|END_ENTITY	Mesenchymal-specific inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- attenuates growth in neonatal mice .
21703259	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced endothelial proliferation , arterial relaxation , vascular permeability and angiogenesis by dobesilate .
21969375	0	vascular_endothelial_growth_factor	31,65	VEGF	67,71	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	b-hairpin peptide that targets vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors : design , NMR characterization , and biological activity .
21978756	0	vascular_endothelial_growth_factor	17,51	VEGF	53,57	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	influence|nmod|START_ENTITY influence|appos|END_ENTITY	The influence of vascular_endothelial_growth_factor -LRB- VEGF -RRB- polymorphism on the progression of chronic glomerulonephritides .
22056013	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- transcript and protein in the testis of several vertebrates , including endangered species .
22153388	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Atorvastatin reduces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human non-small_cell_lung_carcinomas -LRB- NSCLCs -RRB- via inhibition of reactive oxygen species -LRB- ROS -RRB- production .
22272053	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- associated with histopathological changes in rodent models of osteoarthritis .
22286233	0	vascular_endothelial_growth_factor	11,45	VEGF	47,51	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Changes|nmod|START_ENTITY Changes|appos|END_ENTITY	Changes in vascular_endothelial_growth_factor -LRB- VEGF -RRB- induced by the Morris water maze task .
22379030	0	vascular_endothelial_growth_factor	40,74	VEGF	96,100	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	START_ENTITY|dep|expression expression|compound|END_ENTITY	IL-17A differentially regulates corneal vascular_endothelial_growth_factor -LRB- VEGF -RRB- - A and soluble VEGF receptor 1 expression and promotes corneal_angiogenesis_after_herpes_simplex_virus_infection .
22534085	0	vascular_endothelial_growth_factor	97,131	VEGF	133,137	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Paraneoplastic_symptoms : cachexia , polycythemia , and hypercalcemia are , respectively , related to vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in renal_clear_cell_carcinoma .
22558473	0	vascular_endothelial_growth_factor	27,61	VEGF	63,67	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Expressional evaluation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in urinary_bladder_carcinoma patients exposed to cigarette smoke .
22925497	0	vascular_endothelial_growth_factor	16,50	VEGF	52,56	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	The relation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle_cell_disease .
22992725	0	vascular_endothelial_growth_factor	92,126	VEGF	128,132	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Elevated SP-1 transcription factor expression and activity drives basal and hypoxia-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in non-small_cell_lung_cancer .
23061308	0	vascular_endothelial_growth_factor	13,47	VEGF	49,53	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Study of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression and microvascular density -LRB- MVD -RRB- in primary colorectal_cancer specimens .
23161411	0	vascular_endothelial_growth_factor	57,91	VEGF	93,97	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between bevacizumab-related hypertension and vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphisms in Japanese patients with metastatic colorectal_cancer .
23456015	0	vascular_endothelial_growth_factor	41,75	VEGF	77,81	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Prognostic and predictive value of serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- in squamous_cell_carcinoma of the head_and_neck .
23459872	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of autocrine vascular_endothelial_growth_factor -LRB- VEGF -RRB- in non-small_cell_lung_cancer cell line A549 .
23719599	0	vascular_endothelial_growth_factor	15,49	VEGF	95,99	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Association|nmod|START_ENTITY END_ENTITY|nsubj|Association	Association of vascular_endothelial_growth_factor -LRB- VEGF -RRB- gene polymorphism and increased serum VEGF concentration with pancreatic_adenocarcinoma .
23758212	0	vascular_endothelial_growth_factor	17,51	VEGF	53,57	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of salivary vascular_endothelial_growth_factor -LRB- VEGF -RRB- in palatal_mucosal_wound healing .
23780896	0	vascular_endothelial_growth_factor	109,143	VEGF	145,149	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Paraneoplastic hormones : parathyroid_hormone-related_protein -LRB- PTHrP -RRB- and erythropoietin -LRB- EPO -RRB- are related to vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in clear_cell_renal_cell_carcinoma .
23926105	0	vascular_endothelial_growth_factor	136,170	VEGF	172,176	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Loss of epigenetic Kruppel-like factor 4 histone deacetylase -LRB- KLF-4-HDAC -RRB- - mediated transcriptional suppression is crucial in increasing vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in breast_cancer .
24240584	0	vascular_endothelial_growth_factor	29,63	VEGF	65,69	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Positive association between vascular_endothelial_growth_factor -LRB- VEGF -RRB- -2578 _ C/A variant and prostate_cancer .
24557071	0	vascular_endothelial_growth_factor	23,57	VEGF	59,63	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Elevated expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- 120 in parthenogenetic porcine placentas .
24601908	0	vascular_endothelial_growth_factor	36,70	VEGF	72,76	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Protective or pathogenic effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- as potential biomarker in cerebral_malaria .
24833243	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in patients with oral_squamous_cell_carcinoma and its clinical significance .
24857790	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Discovery|nmod|START_ENTITY Discovery|appos|END_ENTITY	Discovery of a novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- with no affinity to heparin in Gloydius tsushimaensis venom .
25653803	0	vascular_endothelial_growth_factor	123,157	VEGF	159,163	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Level|compound|START_ENTITY Level|appos|END_ENTITY	One Possible Mechanism of Pulsed Dye Laser Treatment on Infantile_Hemangioma : Induction of Endothelial Apoptosis and Serum vascular_endothelial_growth_factor -LRB- VEGF -RRB- Level Changes .
25845216	0	vascular_endothelial_growth_factor	88,122	VEGF	124,128	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	-LSB- Effects of electroacupuncture on learning-memory ability and expression of hippocampal vascular_endothelial_growth_factor -LRB- VEGF -RRB- , VEGF receptor 1 and 2 genes in vascular cognitive_impairment rats -RSB- .
25870249	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in prostate_cancer .
26588326	0	vascular_endothelial_growth_factor	15,49	VEGF	51,55	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	The effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on human orbital preadipocyte .
26617878	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- under hypoxia in placenta with intrahepatic_cholestasis_of_pregnancy and its clinically pathological significance .
26788968	0	vascular_endothelial_growth_factor	15,49	VEGF	51,55	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Coffee induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in human neuroblastama SH-SY5Y cells .
7585655	0	vascular_endothelial_growth_factor	18,52	VEGF	54,58	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Expression of the vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor gene , KDR , in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation .
7623107	0	vascular_endothelial_growth_factor	66,100	VEGF	102,106	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Development of retinal vasculature is mediated by hypoxia-induced vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression by neuroglia .
8621443	0	vascular_endothelial_growth_factor	26,60	VEGF	62,66	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain .
8641698	0	vascular_endothelial_growth_factor	26,60	VEGF	67,71	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Localization of the human vascular_endothelial_growth_factor gene , VEGF , at chromosome 6p12 .
8958842	0	vascular_endothelial_growth_factor	35,69	VEGF	71,75	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization and expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the ovine corpus luteum .
8988772	0	vascular_endothelial_growth_factor	10,44	VEGF	46,50	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vascular_endothelial_growth_factor -LRB- VEGF -RRB- on survival of random extension of axial pattern skin flaps in the rat .
8994354	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in retinoblastoma but not in posterior uveal_melanoma .
9155049	0	vascular_endothelial_growth_factor	94,128	VEGF	130,134	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Neoangiogenesis and p53 protein_in_lung_cancer : their prognostic role and their relation with vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression .
9238051	0	vascular_endothelial_growth_factor	25,59	VEGF	61,65	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Conditional switching of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in tumors : induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal .
9386988	0	vascular_endothelial_growth_factor	13,47	VEGF	49,53	vascular endothelial growth factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Detection of vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina .
9395496	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vascular_endothelial_growth_factor -LRB- VEGF -RRB- - induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of VEGF165 .
9476086	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- during folliculogenesis and corpus luteum formation in the human ovary .
9647657	0	vascular_endothelial_growth_factor	43,77	VEGF	79,83	vascular endothelial growth factor	VEGF	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Fibroblast_growth_factor-2 -LRB- FGF-2 -RRB- induces vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in the endothelial cells of forming capillaries : an autocrine mechanism contributing to angiogenesis .
9674707	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Regulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression is mediated by internal initiation of translation and alternative initiation of transcription .
9711425	0	vascular_endothelial_growth_factor	34,68	VEGF	70,74	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Strongly enhanced serum levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- after polytrauma and burn .
9813373	0	vascular_endothelial_growth_factor	21,55	VEGF	57,61	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Hypoxic induction of vascular_endothelial_growth_factor -LRB- VEGF -RRB- protein in astroglial cultures .
9823983	0	vascular_endothelial_growth_factor	20,54	VEGF	56,60	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	value|nmod|START_ENTITY value|appos|END_ENTITY	Predictive value of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in metastasis and prognosis of human colorectal_cancer .
9879835	0	vascular_endothelial_growth_factor	14,48	VEGF	50,54	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in various compartments of the human hair follicle .
9973154	0	vascular_endothelial_growth_factor	16,50	VEGF	52,56	vascular endothelial growth factor	VEGF	7422	7422	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Serum levels of vascular_endothelial_growth_factor -LRB- VEGF -RRB- are markedly elevated in patients with Wegener 's _ granulomatosis .
15492987	0	vascular_endothelial_growth_factor	14,48	VEGF-R1	75,82	vascular endothelial growth factor	VEGF-R1	7422	2321	Gene	Gene	START_ENTITY|dep|-RSB- -RSB-|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and its receptors -LRB- VEGF-R1 -LSB- Flt-1 -RSB- and VEGF-R2 -LSB- KDR/Flk -1 -RSB- -RRB- in tumorlets and in neuroendocrine_cell_hyperplasia of the lung .
19700204	0	vascular_endothelial_growth_factor	61,95	VEGFA	97,102	vascular endothelial growth factor	VEGFA	7422	7422	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Haplotype analysis of single nucleotide polymorphisms in the vascular_endothelial_growth_factor -LRB- VEGFA -RRB- gene and antidepressant treatment response in major depressive_disorder .
22038228	0	vascular_endothelial_growth_factor	81,115	VEGFR	126,131	vascular endothelial growth factor	VEGFR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Nephrotic_syndrome unfavorable course correlates with downregulation of podocyte vascular_endothelial_growth_factor receptor -LRB- VEGFR -RRB- -2 .
27059553	0	vascular_endothelial_growth_factor	32,66	VEGFR	77,82	vascular endothelial growth factor	VEGFR	7422	3791	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Safety and clinical activity of vascular_endothelial_growth_factor receptor -LRB- VEGFR -RRB- - tyrosine kinase inhibitors after programmed cell death 1 inhibitor treatment in patients with metastatic clear_cell_renal_cell_carcinoma .
10747927	0	vascular_endothelial_growth_factor	36,70	VEGFR-1	83,90	vascular endothelial growth factor	VEGFR-1	7422	2321	Gene	Gene	receptor-1|compound|START_ENTITY receptor-1|appos|END_ENTITY	Receptor chimeras indicate that the vascular_endothelial_growth_factor receptor-1 -LRB- VEGFR-1 -RRB- modulates mitogenic activity of VEGFR-2 in endothelial cells .
15111299	0	vascular_endothelial_growth_factor	4,38	VEGFR-1	62,69	vascular endothelial growth factor	VEGFR-1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	Flt-1|amod|START_ENTITY Flt-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
16274253	0	vascular_endothelial_growth_factor	27,61	VEGFR-1	126,133	vascular endothelial growth factor	VEGFR-1	281572(Tax:9913)	503620(Tax:9913)	Gene	Gene	receptors|compound|START_ENTITY regulation|nmod|receptors revealed|nsubj|regulation revealed|nmod|interference interference|dep|interactions interactions|nmod|END_ENTITY	Differential regulation of vascular_endothelial_growth_factor receptors -LRB- VEGFR -RRB- revealed by RNA interference : interactions of VEGFR-1 and VEGFR-2 in endothelial cell signaling .
17599955	0	vascular_endothelial_growth_factor	76,110	VEGFR-1	154,161	vascular endothelial growth factor	VEGFR-1	7422	2321	Gene	Gene	variants|amod|START_ENTITY expression|nmod|variants study|nmod|expression study|dep|END_ENTITY	Quantitative real-time reverse transcription PCR study of the expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- splice variants and VEGF receptors -LRB- VEGFR-1 and VEGFR-2 -RRB- in non_small_cell_lung_cancer .
18317954	0	vascular_endothelial_growth_factor	35,69	VEGFR-1	97,104	vascular endothelial growth factor	VEGFR-1	7422	2321	Gene	Gene	value|nmod|START_ENTITY value|appos|levels levels|amod|END_ENTITY	Prognostic and predictive value of vascular_endothelial_growth_factor and its soluble receptors , VEGFR-1 and VEGFR-2 levels in the sera of small_cell_lung_cancer patients .
18413304	0	vascular_endothelial_growth_factor	35,69	VEGFR-1	82,89	vascular endothelial growth factor	VEGFR-1	7422	2321	Gene	Gene	receptor-1|compound|START_ENTITY receptor-1|appos|END_ENTITY	Hypoxia is responsible for soluble vascular_endothelial_growth_factor receptor-1 -LRB- VEGFR-1 -RRB- but not for soluble endoglin induction in villous trophoblast .
18715621	0	vascular_endothelial_growth_factor	15,49	VEGFR-1	69,76	vascular endothelial growth factor	VEGFR-1	7422	2321	Gene	Gene	levels|nmod|START_ENTITY levels|dep|END_ENTITY	High levels of vascular_endothelial_growth_factor and its receptors -LRB- VEGFR-1 , VEGFR-2 , neuropilin-1 -RRB- are associated with worse outcome in breast_cancer .
20615131	0	vascular_endothelial_growth_factor	24,58	VEGFR-1	78,85	vascular endothelial growth factor	VEGFR-1	7422	2321	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Increased expression of vascular_endothelial_growth_factor and its receptors , VEGFR-1 and VEGFR-2 , in medullary_thyroid_carcinoma .
17036392	0	vascular_endothelial_growth_factor	14,48	VEGFR-1_and_2	67,80	vascular endothelial growth factor	VEGFR-1 and 2	7422	2321;3791	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression of vascular_endothelial_growth_factor and its receptors VEGFR-1_and_2 in gastrointestinal_stromal_tumors , leiomyomas and schwannomas .
10747927	0	vascular_endothelial_growth_factor	36,70	VEGFR-2	124,131	vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	receptor-1|compound|START_ENTITY modulates|nsubj|receptor-1 modulates|dobj|activity activity|nmod|END_ENTITY	Receptor chimeras indicate that the vascular_endothelial_growth_factor receptor-1 -LRB- VEGFR-1 -RRB- modulates mitogenic activity of VEGFR-2 in endothelial cells .
12551914	0	vascular_endothelial_growth_factor	47,81	VEGFR-2	151,158	vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	set|nmod|START_ENTITY essential|nsubj|set essential|nmod|activation activation|nmod|signaling signaling|compound|END_ENTITY	A set of loop-1 and -3 structures in the novel vascular_endothelial_growth_factor -LRB- VEGF -RRB- family member , VEGF-ENZ-7 , is essential for the activation of VEGFR-2 signaling .
15111299	0	vascular_endothelial_growth_factor	4,38	VEGFR-2	88,95	vascular endothelial growth factor	VEGFR-2	22339(Tax:10090)	16542(Tax:10090)	Gene	Gene	Flt-1|amod|START_ENTITY modulates|nsubj|Flt-1 modulates|dobj|Flk-1 Flk-1|appos|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor Flt-1 -LRB- VEGFR-1 -RRB- modulates Flk-1 -LRB- VEGFR-2 -RRB- signaling during blood vessel formation .
15946674	0	vascular_endothelial_growth_factor	102,136	VEGFR-2	149,156	vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	receptor-2|compound|START_ENTITY receptor-2|appos|KDR KDR|compound|END_ENTITY	Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular_endothelial_growth_factor receptor-2 -LRB- VEGFR-2 / KDR -RRB- .
18715621	0	vascular_endothelial_growth_factor	15,49	VEGFR-2	78,85	vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	levels|nmod|START_ENTITY levels|dep|VEGFR-1 VEGFR-1|dep|END_ENTITY	High levels of vascular_endothelial_growth_factor and its receptors -LRB- VEGFR-1 , VEGFR-2 , neuropilin-1 -RRB- are associated with worse outcome in breast_cancer .
19818105	0	vascular_endothelial_growth_factor	40,74	VEGFR-2	122,129	vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	mediated|nsubj|START_ENTITY mediated|xcomp|signaling signaling|nmod|END_ENTITY	Alzheimer 's beta-amyloid_peptide blocks vascular_endothelial_growth_factor mediated signaling via direct interaction with VEGFR-2 .
8617204	0	vascular_endothelial_growth_factor	8,42	VEGFR-2	96,103	vascular endothelial growth factor	VEGFR-2	7422	3791	Gene	Gene	kinases|nsubj|START_ENTITY kinases|amod|ligand ligand|nmod|Flt4 Flt4|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
8617204	0	vascular_endothelial_growth_factor	8,42	VEGFR-3	78,85	vascular endothelial growth factor	VEGFR-3	7422	2324	Gene	Gene	kinases|nsubj|START_ENTITY kinases|amod|ligand ligand|nmod|Flt4 Flt4|appos|END_ENTITY	A novel vascular_endothelial_growth_factor , VEGF-C , is a ligand for the Flt4 -LRB- VEGFR-3 -RRB- and KDR -LRB- VEGFR-2 -RRB- receptor tyrosine kinases .
16104843	0	vascular_endothelial_growth_factor	4,38	VEGF_receptor	46,59	vascular endothelial growth factor	VEGF receptor	7422	3791	Gene	Gene	START_ENTITY|dep|system system|compound|END_ENTITY	The vascular_endothelial_growth_factor -LRB- VEGF -RRB- / VEGF_receptor system and its role under physiological and pathological conditions .
9323935	0	vascular_endothelial_growth_factor	148,182	Vascular_endothelial_growth_factor	0,34	vascular endothelial growth factor	Vascular endothelial growth factor	7422	7422	Gene	Gene	role|nmod|START_ENTITY END_ENTITY|dep|role	Vascular_endothelial_growth_factor and severity of nonproliferative_diabetic_retinopathy mediate retinal hemodynamics in vivo : a potential role for vascular_endothelial_growth_factor in the progression of nonproliferative_diabetic_retinopathy .
12461084	0	vascular_endothelial_growth_factor	29,63	Vascular_permeability_factor	0,28	vascular endothelial growth factor	Vascular permeability factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY END_ENTITY|parataxis|induces	Vascular_permeability_factor / vascular_endothelial_growth_factor induces lymphangiogenesis as well as angiogenesis .
9426404	0	vascular_endothelial_growth_factor	29,63	Vascular_permeability_factor	0,28	vascular endothelial growth factor	Vascular permeability factor	7422	7422	Gene	Gene	/|dobj|START_ENTITY /|nsubj|END_ENTITY	Vascular_permeability_factor / vascular_endothelial_growth_factor and its receptors in oral and laryngeal_squamous_cell_carcinoma and dysplasia .
10096773	0	vascular_endothelial_growth_factor	22,56	Vasopressin	0,11	vascular endothelial growth factor	Vasopressin	7422	551	Gene	Gene	secretion|compound|START_ENTITY increases|dobj|secretion increases|nsubj|END_ENTITY	Vasopressin increases vascular_endothelial_growth_factor secretion from human vascular smooth muscle cells .
16019439	0	vascular_endothelial_growth_factor	55,89	WISH	109,113	vascular endothelial growth factor	WISH	7422	51517	Gene	Gene	START_ENTITY|nmod|cells cells|appos|END_ENTITY	The effect of epidermal_growth_factor on production of vascular_endothelial_growth_factor by amnion-derived -LRB- WISH -RRB- cells .
17127464	0	vascular_endothelial_growth_factor	14,48	WT1	95,98	vascular endothelial growth factor	WT1	7422	7490	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|appos|END_ENTITY	Regulation of vascular_endothelial_growth_factor , VEGF , gene promoter by the tumor suppressor , WT1 .
10667597	0	vascular_endothelial_growth_factor	45,79	ZK7	0,3	vascular endothelial growth factor	ZK7	7422	7678	Gene	Gene	induced|nmod|START_ENTITY induced|nsubjpass|END_ENTITY	ZK7 , a novel zinc finger gene , is induced by vascular_endothelial_growth_factor and inhibits apoptotic death in hematopoietic cells .
25821324	0	vascular_endothelial_growth_factor	39,73	adiponectin	10,21	vascular endothelial growth factor	adiponectin	7422	9370	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effect of adiponectin on expression of vascular_endothelial_growth_factor and pigment epithelium-derived factor : An in vitro study .
21558971	0	vascular_endothelial_growth_factor	43,77	adrenomedullin	20,34	vascular endothelial growth factor	adrenomedullin	22339(Tax:10090)	11535(Tax:10090)	Gene	Gene	induction|compound|START_ENTITY roles|nmod|induction roles|nmod|END_ENTITY	Angiogenic roles of adrenomedullin through vascular_endothelial_growth_factor induction .
20413783	0	vascular_endothelial_growth_factor	18,52	afadin	8,14	vascular endothelial growth factor	afadin	7422	17356(Tax:10090)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of afadin in vascular_endothelial_growth_factor - and sphingosine_1-phosphate-induced angiogenesis .
10862607	0	vascular_endothelial_growth_factor	69,103	alpha_2-macroglobulin	42,63	vascular endothelial growth factor	alpha 2-macroglobulin	7422	2	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The conformation-dependent interaction of alpha_2-macroglobulin with vascular_endothelial_growth_factor .
16278385	0	vascular_endothelial_growth_factor	55,89	androgen_receptor	4,21	vascular endothelial growth factor	androgen receptor	7422	367	Gene	Gene	associated|nmod|START_ENTITY associated|nsubjpass|END_ENTITY	The androgen_receptor is significantly associated with vascular_endothelial_growth_factor and hypoxia sensing via hypoxia-inducible factors HIF-1a , HIF-2a , and the prolyl hydroxylases in human prostate_cancer .
12810677	0	vascular_endothelial_growth_factor	14,48	angiopoietin-2	62,76	vascular endothelial growth factor	angiopoietin-2	7422	285	Gene	Gene	up-regulates|compound|START_ENTITY up-regulates|amod|END_ENTITY	Tumor-derived vascular_endothelial_growth_factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature , supporting angiogenesis in ovarian_cancer .
11805186	0	vascular_endothelial_growth_factor	76,110	angiopoietin_1	24,38	vascular endothelial growth factor	angiopoietin 1	7422	284	Gene	Gene	regulator|nmod|START_ENTITY END_ENTITY|appos|regulator	Human podocytes express angiopoietin_1 , a potential regulator of glomerular vascular_endothelial_growth_factor .
10203356	0	vascular_endothelial_growth_factor	56,90	angiotensin_II	15,29	vascular endothelial growth factor	angiotensin II	7422	183	Gene	Gene	production|compound|START_ENTITY stretch|nmod|production stretch|nsubj|Interaction Interaction|nmod|END_ENTITY	Interaction of angiotensin_II and mechanical stretch on vascular_endothelial_growth_factor production by human mesangial cells .
15572520	0	vascular_endothelial_growth_factor	28,62	angiotensin_II	103,117	vascular endothelial growth factor	angiotensin II	7422	183	Gene	Gene	expression|compound|START_ENTITY regulation|nmod|expression regulation|nmod|END_ENTITY	Translational regulation of vascular_endothelial_growth_factor expression in renal epithelial cells by angiotensin_II .
16085213	0	vascular_endothelial_growth_factor	37,71	angiotensin_II	19,33	vascular endothelial growth factor	angiotensin II	7422	183	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Essential roles of angiotensin_II in vascular_endothelial_growth_factor expression in sleep_apnea_syndrome .
17581920	0	vascular_endothelial_growth_factor	87,121	angiotensin_II	57,71	vascular endothelial growth factor	angiotensin II	7422	183	Gene	Gene	translation|compound|START_ENTITY stimulation|nmod|translation stimulation|amod|END_ENTITY	Heterogeneous_nuclear_ribonucleoprotein_K contributes to angiotensin_II stimulation of vascular_endothelial_growth_factor mRNA translation .
22382381	0	vascular_endothelial_growth_factor	24,58	angiotensin_II	114,128	vascular endothelial growth factor	angiotensin II	7422	183	Gene	Gene	secretion|compound|START_ENTITY stimulates|dobj|secretion stimulates|nmod|fibroblasts fibroblasts|nmod|synergy synergy|nmod|END_ENTITY	Urotensin_II stimulates vascular_endothelial_growth_factor secretion from adventitial fibroblasts in synergy with angiotensin_II .
9531974	0	vascular_endothelial_growth_factor	16,50	angiotensin_II	54,68	vascular endothelial growth factor	angiotensin II	83785(Tax:10116)	24179(Tax:10116)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor by angiotensin_II in rat heart endothelial cells .
11479208	0	vascular_endothelial_growth_factor	37,71	basic_fibroblast_growth_factor	88,118	vascular endothelial growth factor	basic fibroblast growth factor	7422	2247	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|appos|independent independent|nmod|END_ENTITY	HIF-1alpha-mediated up-regulation of vascular_endothelial_growth_factor , independent of basic_fibroblast_growth_factor , is important in the switch to the angiogenic phenotype during early tumorigenesis .
11774282	0	vascular_endothelial_growth_factor	30,64	basic_fibroblast_growth_factor	105,135	vascular endothelial growth factor	basic fibroblast growth factor	7422	2247	Gene	Gene	START_ENTITY|xcomp|induce induce|ccomp|END_ENTITY	Human chondrosarcoma secretes vascular_endothelial_growth_factor to induce tumor angiogenesis and stores basic_fibroblast_growth_factor for regulation of its own growth .
25271020	0	vascular_endothelial_growth_factor	35,69	basic_fibroblast_growth_factor	70,100	vascular endothelial growth factor	basic fibroblast growth factor	22339(Tax:10090)	14173(Tax:10090)	Gene	Gene	production|nmod|START_ENTITY production|parataxis|peptide peptide|nsubj|complex complex|compound|END_ENTITY	Soluble production and function of vascular_endothelial_growth_factor / basic_fibroblast_growth_factor complex peptide .
8636009	0	vascular_endothelial_growth_factor	92,126	basic_fibroblast_growth_factor	127,157	vascular endothelial growth factor	basic fibroblast growth factor	7422	2247	Gene	Gene	/|compound|START_ENTITY /|amod|END_ENTITY	Dual pathways of tubular morphogenesis of vascular endothelial cells by human glioma cells : vascular_endothelial_growth_factor / basic_fibroblast_growth_factor and interleukin-8 .
12810642	0	vascular_endothelial_growth_factor	23,57	beta-Catenin	0,12	vascular endothelial growth factor	beta-Catenin	7422	1499	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	beta-Catenin regulates vascular_endothelial_growth_factor expression in colon_cancer .
15662032	0	vascular_endothelial_growth_factor	92,126	beta-catenin	30,42	vascular endothelial growth factor	beta-catenin	7422	1499	Gene	Gene	activation|nmod|START_ENTITY promotes|nmod|activation promotes|nsubj|axis axis|amod|END_ENTITY	Glycogen-Synthase_Kinase3beta / beta-catenin axis promotes angiogenesis through activation of vascular_endothelial_growth_factor signaling in endothelial cells .
22041018	0	vascular_endothelial_growth_factor	66,100	bone_morphogenetic_protein-2	12,40	vascular endothelial growth factor	bone morphogenetic protein-2	7422	650	Gene	Gene	up-regulation|nmod|START_ENTITY up-regulation|amod|END_ENTITY	Recombinant bone_morphogenetic_protein-2 induces up-regulation of vascular_endothelial_growth_factor and interleukin_6 in human pre-osteoblasts : role of reactive oxygen species .
11255225	0	vascular_endothelial_growth_factor	70,104	bone_morphogenetic_protein-4	118,146	vascular endothelial growth factor	bone morphogenetic protein-4	22339(Tax:10090)	12159(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY synthesis|nmod|END_ENTITY	Involvement of p70 S6 kinase in bone morphogenetic protein signaling : vascular_endothelial_growth_factor synthesis by bone_morphogenetic_protein-4 in osteoblasts .
15839936	0	vascular_endothelial_growth_factor	89,123	brain-derived_neurotrophic_factor	41,74	vascular endothelial growth factor	brain-derived neurotrophic factor	83785(Tax:10116)	24225(Tax:10116)	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|effect effect|nmod|END_ENTITY	The additive erectile recovery effect of brain-derived_neurotrophic_factor combined with vascular_endothelial_growth_factor in a rat model of neurogenic_impotence .
22816673	0	vascular_endothelial_growth_factor	70,104	breast_cancer_anti-estrogen_resistance_1	14,54	vascular endothelial growth factor	breast cancer anti-estrogen resistance 1	7422	9564	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of breast_cancer_anti-estrogen_resistance_1 in relation to vascular_endothelial_growth_factor , p53 , and prognosis in esophageal_squamous_cell_cancer .
10640727	0	vascular_endothelial_growth_factor	80,114	c-Src	0,5	vascular endothelial growth factor	c-Src	7422	6714	Gene	Gene	stimulation|compound|START_ENTITY mediates|nmod|stimulation mediates|nsubj|END_ENTITY	c-Src mediates mitogenic signals and associates with cytoskeletal proteins upon vascular_endothelial_growth_factor stimulation in Kaposi 's _ sarcoma cells .
18180305	0	vascular_endothelial_growth_factor	105,139	c-Src	60,65	vascular endothelial growth factor	c-Src	7422	6714	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	A novel role of vascular_endothelial_cadherin in modulating c-Src activation and downstream signaling of vascular_endothelial_growth_factor .
7540725	0	vascular_endothelial_growth_factor	27,61	c-Src	81,86	vascular endothelial growth factor	c-Src	7422	6714	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression induction|nmod|activation activation|amod|END_ENTITY	Hypoxic induction of human vascular_endothelial_growth_factor expression through c-Src activation .
14687787	0	vascular_endothelial_growth_factor	64,98	c-erbB-2	18,26	vascular endothelial growth factor	c-erbB-2	7422	2064	Gene	Gene	expression|nmod|START_ENTITY related|nmod|expression related|nsubjpass|Overexpression Overexpression|nmod|END_ENTITY	Overexpression of c-erbB-2 is related to a higher expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- and constitutes an independent prognostic factor in primary node-positive_breast_cancer after adjuvant systemic treatment .
14607712	0	vascular_endothelial_growth_factor	15,49	c-fos	109,114	vascular endothelial growth factor	c-fos	7422	2353	Gene	Gene	Expressions|nmod|START_ENTITY Expressions|nmod|END_ENTITY	Expressions of vascular_endothelial_growth_factor in cirrhotic tissues and their relations to proto-oncogene c-fos , c-myc .
9422768	0	vascular_endothelial_growth_factor	19,53	c-src	152,157	vascular endothelial growth factor	c-src	7422	6714	Gene	Gene	Down-regulation|nmod|START_ENTITY transfected|nsubj|Down-regulation transfected|advcl|END_ENTITY	Down-regulation of vascular_endothelial_growth_factor in a human colon_carcinoma cell line transfected with an antisense expression vector specific for c-src .
12114504	0	vascular_endothelial_growth_factor	103,137	connective_tissue_growth_factor	33,64	vascular endothelial growth factor	connective tissue growth factor	22339(Tax:10090)	14219(Tax:10090)	Gene	Gene	activity|nmod|START_ENTITY activity|amod|END_ENTITY	Matrix metalloproteinases cleave connective_tissue_growth_factor and reactivate angiogenic activity of vascular_endothelial_growth_factor 165 .
16432171	0	vascular_endothelial_growth_factor	130,164	connective_tissue_growth_factor	83,114	vascular endothelial growth factor	connective tissue growth factor	7422	1490	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|dobj|induction induction|nmod|END_ENTITY	Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective_tissue_growth_factor -LRB- CTGF/CCN2 -RRB- by vascular_endothelial_growth_factor in human endothelial cells .
17355828	0	vascular_endothelial_growth_factor	99,133	connective_tissue_growth_factor	46,77	vascular endothelial growth factor	connective tissue growth factor	7422	1490	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Inhibition effect of small interfering RNA of connective_tissue_growth_factor on the expression of vascular_endothelial_growth_factor and connective_tissue_growth_factor in cultured human peritoneal mesothelial cells .
18484196	0	vascular_endothelial_growth_factor	62,96	corticotropin-releasing_hormone	11,42	vascular endothelial growth factor	corticotropin-releasing hormone	7422	1392	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effects of corticotropin-releasing_hormone and stresscopin on vascular_endothelial_growth_factor mRNA expression in cultured early human extravillous trophoblasts .
25225463	0	vascular_endothelial_growth_factor	59,93	cyclin_D1	113,122	vascular endothelial growth factor	cyclin D1	7422	595	Gene	Gene	epidermal|dep|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
10919714	0	vascular_endothelial_growth_factor	16,50	cyclooxygenase-2	127,143	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	Upregulation|nmod|START_ENTITY mediated|nsubjpass|Upregulation mediated|nmod|induction induction|nmod|line line|amod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor by cobalt_chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human_prostate_cancer cell line .
11381123	0	vascular_endothelial_growth_factor	93,127	cyclooxygenase-2	13,29	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	production|compound|START_ENTITY involved|nmod|production involved|nsubjpass|Induction Induction|nmod|END_ENTITY	Induction of cyclooxygenase-2 by Epstein-Barr_virus latent membrane protein 1 is involved in vascular_endothelial_growth_factor production in nasopharyngeal_carcinoma cells .
14558947	0	vascular_endothelial_growth_factor	74,108	cyclooxygenase-2	21,37	vascular endothelial growth factor	cyclooxygenase-2	22339(Tax:10090)	19225(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY celebrex|nmod|expression celebrex|amod|END_ENTITY	-LSB- Effect of selective cyclooxygenase-2 inhibitor celebrex on expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in pancreatic_carcinoma -RSB- .
15585326	0	vascular_endothelial_growth_factor	45,79	cyclooxygenase-2	4,20	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|DFU DFU|amod|END_ENTITY	New cyclooxygenase-2 inhibitor DFU regulates vascular_endothelial_growth_factor expression in rheumatoid_synoviocytes .
15704107	0	vascular_endothelial_growth_factor	50,84	cyclooxygenase-2	6,22	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	levels|compound|START_ENTITY correlate|nmod|levels correlate|nsubj|levels levels|amod|END_ENTITY	Total cyclooxygenase-2 mRNA levels correlate with vascular_endothelial_growth_factor mRNA levels , tumor angiogenesis and prognosis in non-small_cell_lung_cancer patients .
16015035	0	vascular_endothelial_growth_factor	10,44	cyclooxygenase-2	163,179	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	START_ENTITY|parataxis|represents represents|dobj|target target|nmod|NS-398 NS-398|amod|END_ENTITY	Autocrine vascular_endothelial_growth_factor / vascular_endothelial_growth_factor_receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon_cancer cells .
16515599	0	vascular_endothelial_growth_factor	80,114	cyclooxygenase-2	14,30	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	expression|compound|START_ENTITY Expression|nmod|expression Expression|nmod|END_ENTITY	Expression of cyclooxygenase-2 in epithelial_ovarian_tumors and its relation to vascular_endothelial_growth_factor and p53 expression .
20222044	0	vascular_endothelial_growth_factor	70,104	cyclooxygenase-2	29,45	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	production|compound|START_ENTITY effects|nmod|production effects|nmod|inhibitors inhibitors|amod|END_ENTITY	Differential effects between cyclooxygenase-2 inhibitors and siRNA on vascular_endothelial_growth_factor production in head_and_neck_squamous_cell_carcinoma cell lines .
20939988	0	vascular_endothelial_growth_factor	79,113	cyclooxygenase-2	192,208	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	START_ENTITY|nmod|MKN45 MKN45|acl|induced induced|advcl|inhibiting inhibiting|dobj|-RSB- -RSB-|amod|END_ENTITY	-LSB- Chinese herbal medicine Jianpi Jiedu Formula down-regulates the expression of vascular_endothelial_growth_factor in human gastric cell line MKN45 induced by Helicobacter_pylori by inhibiting cyclooxygenase-2 -RSB- .
22009181	0	vascular_endothelial_growth_factor	57,91	cyclooxygenase-2	27,43	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	expression|compound|START_ENTITY inhibitor|nmod|expression inhibitor|amod|END_ENTITY	Dual action of a selective cyclooxygenase-2 inhibitor on vascular_endothelial_growth_factor expression in human hepatocellular_carcinoma cells : novel involvement of discoidin_domain_receptor_2 .
25225463	0	vascular_endothelial_growth_factor	59,93	cyclooxygenase-2	95,111	vascular endothelial growth factor	cyclooxygenase-2	7422	5743	Gene	Gene	epidermal|dep|START_ENTITY epidermal|amod|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
11156212	0	vascular_endothelial_growth_factor	62,96	endostatin	6,16	vascular endothelial growth factor	endostatin	7422	80781	Gene	Gene	levels|compound|START_ENTITY elevated|nmod|levels elevated|nsubj|levels levels|compound|END_ENTITY	Serum endostatin levels are elevated and correlate with serum vascular_endothelial_growth_factor levels in patients with stage IV_clear_cell_renal_cancer .
12354694	0	vascular_endothelial_growth_factor	93,127	endostatin	26,36	vascular endothelial growth factor	endostatin	22339(Tax:10090)	12822(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY down-regulation|nmod|expression associated|nmod|down-regulation associated|nsubjpass|effect effect|nmod|END_ENTITY	The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular_endothelial_growth_factor expression in tumor cells .
15484319	0	vascular_endothelial_growth_factor	39,73	endostatin	11,21	vascular endothelial growth factor	endostatin	22339(Tax:10090)	12822(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Effects of endostatin on expression of vascular_endothelial_growth_factor and its receptors and neovascularization in colonic_carcinoma implanted in nude_mice .
16198337	0	vascular_endothelial_growth_factor	18,52	endostatin	74,84	vascular endothelial growth factor	endostatin	22339(Tax:10090)	12822(Tax:10090)	Gene	Gene	Downregulation|nmod|START_ENTITY Downregulation|nmod|END_ENTITY	Downregulation of vascular_endothelial_growth_factor and integrinbeta3 by endostatin in a mouse model of retinal_neovascularization .
16379029	0	vascular_endothelial_growth_factor	62,96	endostatin	6,16	vascular endothelial growth factor	endostatin	7422	80781	Gene	Gene	levels|compound|START_ENTITY elevated|nmod|levels elevated|nsubj|levels levels|compound|END_ENTITY	Serum endostatin levels are elevated and correlate with serum vascular_endothelial_growth_factor levels in patients with pituitary_adenomas .
17181918	0	vascular_endothelial_growth_factor	31,65	endostatin	69,79	vascular endothelial growth factor	endostatin	7422	80781	Gene	Gene	ratio|nmod|START_ENTITY ratio|acl|END_ENTITY	Decreased ratio of circulatory vascular_endothelial_growth_factor to endostatin in patients with systemic_sclerosis -- association with pulmonary_involvement .
21672421	0	vascular_endothelial_growth_factor	40,74	endostatin	75,85	vascular endothelial growth factor	endostatin	7422	80781	Gene	Gene	ratio|nmod|START_ENTITY Correlation|nmod|ratio Correlation|dep|END_ENTITY	-LSB- Correlation between the ratio of serum vascular_endothelial_growth_factor / endostatin and childhood acute_leukemia -RSB- .
24648897	0	vascular_endothelial_growth_factor	61,95	endostatin	29,39	vascular endothelial growth factor	endostatin	7422	80781	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of recombinant human endostatin on the expression of vascular_endothelial_growth_factor in human gastric_cancer cell line MGC-803 .
11301389	0	vascular_endothelial_growth_factor	14,48	endothelial_PAS_domain_protein_1	66,98	vascular endothelial growth factor	endothelial PAS domain protein 1	7422	2034	Gene	Gene	Regulation|nmod|START_ENTITY transcription|nsubj|Regulation transcription|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor transcription by endothelial_PAS_domain_protein_1 -LRB- EPAS1 -RRB- and possible involvement of EPAS1 in the angiogenesis of renal_cell_carcinoma .
19080330	0	vascular_endothelial_growth_factor	82,116	endothelial_PAS_domain_protein_1	10,42	vascular endothelial growth factor	endothelial PAS domain protein 1	7422	2034	Gene	Gene	expression|compound|START_ENTITY Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of endothelial_PAS_domain_protein_1 and hypoxia_inducible_factor_1alpha on vascular_endothelial_growth_factor expression in human pancreatic_carcinoma .
15621731	0	vascular_endothelial_growth_factor	121,155	endothelin-1	17,29	vascular endothelial growth factor	endothelin-1	7422	1906	Gene	Gene	inhibited|nmod|START_ENTITY inhibited|nsubjpass|secretion secretion|nmod|cells cells|amod|END_ENTITY	The secretion of endothelin-1 by microvascular endothelial cells from human benign_prostatic_hyperplasia is inhibited by vascular_endothelial_growth_factor .
23458507	0	vascular_endothelial_growth_factor	20,54	endothelin-1	90,102	vascular endothelial growth factor	endothelin-1	7422	1906	Gene	Gene	inhibition|compound|START_ENTITY Hypertension|nmod|inhibition Hypertension|dep|focus focus|nmod|END_ENTITY	Hypertension during vascular_endothelial_growth_factor inhibition : focus on nitric_oxide , endothelin-1 , and oxidative stress .
24607779	0	vascular_endothelial_growth_factor	11,45	endothelin-1	49,61	vascular endothelial growth factor	endothelin-1	7422	1906	Gene	Gene	START_ENTITY|nmod|production production|amod|END_ENTITY	Effects of vascular_endothelial_growth_factor on endothelin-1 production by human lung microvascular endothelial cells in vitro .
12667326	0	vascular_endothelial_growth_factor	67,101	epidermal_growth_factor	21,44	vascular endothelial growth factor	epidermal growth factor	7422	1950	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	-LSB- Correlation between epidermal_growth_factor and overexpression of vascular_endothelial_growth_factor in hepatocellular_carcinoma -RSB- .
12910515	0	vascular_endothelial_growth_factor	39,73	epidermal_growth_factor	99,122	vascular endothelial growth factor	epidermal growth factor	7422	1950	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|amod|neuropilin-1 neuropilin-1|nmod|END_ENTITY	Expression and regulation of the novel vascular_endothelial_growth_factor receptor neuropilin-1 by epidermal_growth_factor in human pancreatic_carcinoma .
15367698	0	vascular_endothelial_growth_factor	10,44	epidermal_growth_factor	113,136	vascular endothelial growth factor	epidermal growth factor	7422	1950	Gene	Gene	inhibitor|compound|START_ENTITY inhibitor|nmod|activity activity|nmod|kinase kinase|compound|END_ENTITY	ZD6474 , a vascular_endothelial_growth_factor receptor tyrosine kinase inhibitor with additional activity against epidermal_growth_factor receptor tyrosine kinase , inhibits orthotopic growth and angiogenesis of gastric_cancer .
16019439	0	vascular_endothelial_growth_factor	55,89	epidermal_growth_factor	14,37	vascular endothelial growth factor	epidermal growth factor	7422	1950	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of epidermal_growth_factor on production of vascular_endothelial_growth_factor by amnion-derived -LRB- WISH -RRB- cells .
23495770	0	vascular_endothelial_growth_factor	46,80	epidermal_growth_factor	105,128	vascular endothelial growth factor	epidermal growth factor	7422	1950	Gene	Gene	IL-8|appos|START_ENTITY cells|appos|IL-8 END_ENTITY|nsubj|cells	Regulatory T cells , interleukin _ -LRB- IL -RRB- -6 , IL-8 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , CXCL10 , CXCL11 , epidermal_growth_factor -LRB- EGF -RRB- and hepatocyte_growth_factor -LRB- HGF -RRB- as surrogate markers of host immunity in patients with renal_cell_carcinoma .
25225463	0	vascular_endothelial_growth_factor	59,93	epidermal_growth_factor_receptor	14,46	vascular endothelial growth factor	epidermal growth factor receptor	7422	1956	Gene	Gene	epidermal|dep|START_ENTITY epidermal|compound|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
10408258	0	vascular_endothelial_growth_factor	44,78	erythropoietin	18,32	vascular endothelial growth factor	erythropoietin	7422	2056	Gene	Gene	release|compound|START_ENTITY stimulates|dobj|release stimulates|nsubj|END_ENTITY	Recombinant human erythropoietin stimulates vascular_endothelial_growth_factor release by glomerular endothelial cells .
11045267	0	vascular_endothelial_growth_factor	15,49	erythropoietin	67,81	vascular endothelial growth factor	erythropoietin	7422	2056	Gene	Gene	level|nmod|START_ENTITY influenced|nsubjpass|level influenced|nmod|treatment treatment|compound|END_ENTITY	Serum level of vascular_endothelial_growth_factor is influenced by erythropoietin treatment in peritoneal_dialysis patients .
21365780	0	vascular_endothelial_growth_factor	9,43	erythropoietin	72,86	vascular endothelial growth factor	erythropoietin	7422	2056	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	Elevated vascular_endothelial_growth_factor is correlated with elevated erythropoietin in stable , young cystic_fibrosis patients .
21819507	0	vascular_endothelial_growth_factor	25,59	erythropoietin	150,164	vascular endothelial growth factor	erythropoietin	7422	2056	Gene	Gene	levels|nmod|START_ENTITY humour|dobj|levels humour|nmod|injection injection|compound|END_ENTITY	Aqueous humour levels of vascular_endothelial_growth_factor and erythropoietin in patients with diabetic_macular_oedema before and after intravitreal erythropoietin injection .
27081865	0	vascular_endothelial_growth_factor	47,81	erythropoietin	10,24	vascular endothelial growth factor	erythropoietin	7422	2056	Gene	Gene	levels|compound|START_ENTITY agents|nmod|levels stimulating|dobj|agents stimulating|nsubj|Effect Effect|nmod|END_ENTITY	Effect of erythropoietin stimulating agents on vascular_endothelial_growth_factor levels in patients with end_stage_renal_disease .
19398483	0	vascular_endothelial_growth_factor	23,57	estrogen_receptor_alpha	109,132	vascular endothelial growth factor	estrogen receptor alpha	7422	2099	Gene	Gene	regulation|nmod|START_ENTITY regulation|dep|role role|nmod|END_ENTITY	Estrogen regulation of vascular_endothelial_growth_factor in breast_cancer in vitro and in vivo : the role of estrogen_receptor_alpha and c-Myc .
24363282	0	vascular_endothelial_growth_factor	15,49	eukaryotic_elongation_factor_2	70,100	vascular endothelial growth factor	eukaryotic elongation factor 2	7422	1938	Gene	Gene	START_ENTITY|nmod|inactivation inactivation|nmod|END_ENTITY	Suppression of vascular_endothelial_growth_factor via inactivation of eukaryotic_elongation_factor_2 by alkaloids in Coptidis rhizome in hepatocellular_carcinoma .
15669079	1	vascular_endothelial_growth_factor	264,298	fatty_acid_synthase	167,186	vascular endothelial growth factor	fatty acid synthase	7422	2194	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|dep|expression	Characterization of a novel molecular connection between fatty_acid_synthase -LRB- FAS -RRB- and hypoxia-inducible_factor-1alpha -LRB- HIF-1alpha -RRB- - related expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in cancer cells overexpressing her-2 / neu oncogene .
11723743	0	vascular_endothelial_growth_factor	14,48	fetal_liver_kinase-1	113,133	vascular endothelial growth factor	fetal liver kinase-1	7422	3791	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|Flk-1 Flk-1|dep|END_ENTITY	Expression of vascular_endothelial_growth_factor and its receptor KDR -LRB- kinase_domain-containing_receptor -RRB- / Flk-1 -LRB- fetal_liver_kinase-1 -RRB- as prognostic factors in human colorectal_cancer .
15780476	0	vascular_endothelial_growth_factor	15,49	fetal_liver_kinase-1	60,80	vascular endothelial growth factor	fetal liver kinase-1	83785(Tax:10116)	25589(Tax:10116)	Gene	Gene	receptor|compound|START_ENTITY receptor|appos|END_ENTITY	Reduction of a vascular_endothelial_growth_factor receptor , fetal_liver_kinase-1 , by antisense oligonucleotides induces motor neuron_death in rat spinal cord exposed to hypoxia .
9053843	0	vascular_endothelial_growth_factor	18,52	fibroblast_growth_factor_2	101,127	vascular endothelial growth factor	fibroblast growth factor 2	83785(Tax:10116)	54250(Tax:10116)	Gene	Gene	Overexpression|nmod|START_ENTITY induces|nsubj|Overexpression induces|nmod|END_ENTITY	Overexpression of vascular_endothelial_growth_factor induces cell transformation in cooperation with fibroblast_growth_factor_2 .
9305872	0	vascular_endothelial_growth_factor	83,117	fibroblast_growth_factor_2	26,52	vascular endothelial growth factor	fibroblast growth factor 2	7422	2247	Gene	Gene	release|nmod|START_ENTITY release|nmod|END_ENTITY	Cell release of bioactive fibroblast_growth_factor_2 by exon 6-encoded sequence of vascular_endothelial_growth_factor .
10211995	0	vascular_endothelial_growth_factor	153,187	flk-1	197,202	vascular endothelial growth factor	flk-1	7422	3791	Gene	Gene	receptor|compound|START_ENTITY END_ENTITY|dep|receptor	Hepatocyte growth factor increases expression of vascular_endothelial_growth_factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular_endothelial_growth_factor receptor flk-1 in human endothelial cells .
15235888	0	vascular_endothelial_growth_factor	14,48	flk-1	62,67	vascular endothelial growth factor	flk-1	7422	3791	Gene	Gene	Expression|nmod|START_ENTITY Expression|amod|END_ENTITY	Expression of vascular_endothelial_growth_factor and receptor flk-1 in colon_cancer_liver_metastases .
8568762	0	vascular_endothelial_growth_factor	16,50	flt	69,72	vascular endothelial growth factor	flt	7422	2321	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of vascular_endothelial_growth_factor and its receptor , flt , in human placenta and decidua by immunohistochemistry .
9463589	0	vascular_endothelial_growth_factor	31,65	flt	83,86	vascular endothelial growth factor	flt	7422	2321	Gene	Gene	Expression|nmod|START_ENTITY END_ENTITY|nsubj|Expression	Expression and localization of vascular_endothelial_growth_factor and its receptor flt in pulmonary_sarcoidosis .
12142732	0	vascular_endothelial_growth_factor	85,119	flt-1	79,84	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	receptor|compound|START_ENTITY receptor|amod|END_ENTITY	Gene therapy for pancreatic_cancer using an adenovirus vector encoding soluble flt-1 vascular_endothelial_growth_factor receptor .
15515760	0	vascular_endothelial_growth_factor	15,49	flt-1	69,74	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	-LSB- Expression of vascular_endothelial_growth_factor and its receptors -LRB- flt-1 -RRB- in morbid human corneas and investigation of its clinic importance -RSB- .
17099154	0	vascular_endothelial_growth_factor	14,48	flt-1	103,108	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of vascular_endothelial_growth_factor , basic_fibroblast_growth_factor , and their receptors -LRB- flt-1 , flk-1 , and flg-1 -RRB- in canine vascular_tumors .
18478945	0	vascular_endothelial_growth_factor	12,46	flt-1	117,122	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	Effects|nmod|START_ENTITY antisense|nsubj|Effects antisense|xcomp|END_ENTITY	-LSB- Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- antisense oligodeoxynucleotide on mRNA and expression of VEGF , flt-1 , and kinase_insert_domain_containing_receptor and VEGF excretion in human gallbladder_carcinoma cells -RSB- .
7499271	0	vascular_endothelial_growth_factor	21,55	flt-1	66,71	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	receptor|compound|START_ENTITY receptor|dep|END_ENTITY	A novel promoter for vascular_endothelial_growth_factor receptor -LRB- flt-1 -RRB- that confers endothelial-specific gene expression .
8605350	0	vascular_endothelial_growth_factor	44,78	flt-1	120,125	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	response|nmod|START_ENTITY monocytes|nmod|response Migration|nmod|monocytes mediated|nsubjpass|Migration mediated|nmod|END_ENTITY	Migration of human monocytes in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- is mediated via the VEGF receptor flt-1 .
8940064	0	vascular_endothelial_growth_factor	114,148	flt-1	91,96	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	receptor|compound|START_ENTITY gene|dep|receptor gene|amod|tyrosine tyrosine|amod|END_ENTITY	A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase -LRB- vascular_endothelial_growth_factor receptor 1 -RRB- gene .
9042161	0	vascular_endothelial_growth_factor	106,140	flt-1	58,63	vascular endothelial growth factor	flt-1	7422	2321	Gene	Gene	express|nmod|START_ENTITY express|dobj|receptors receptors|dep|END_ENTITY	Uterine smooth muscle cells express functional receptors -LRB- flt-1 and KDR -RRB- for vascular_permeability_factor / vascular_endothelial_growth_factor .
9777366	0	vascular_endothelial_growth_factor	48,82	flt-1	100,105	vascular endothelial growth factor	flt-1	83785(Tax:10116)	54251(Tax:10116)	Gene	Gene	Evidence|nmod|START_ENTITY receptors|nsubj|Evidence receptors|xcomp|END_ENTITY	Evidence for upregulation and redistribution of vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptors flt-1 and flk-1 in the oxygen-injured rat retina .
11696015	0	vascular_endothelial_growth_factor	28,62	focal_adhesion_kinase	89,110	vascular endothelial growth factor	focal adhesion kinase	7422	5747	Gene	Gene	START_ENTITY|nmod|phosphorylation phosphorylation|nmod|END_ENTITY	Src mediates stimulation by vascular_endothelial_growth_factor of the phosphorylation of focal_adhesion_kinase at tyrosine 861 , and migration and anti-apoptosis in endothelial cells .
11927607	0	vascular_endothelial_growth_factor	76,110	focal_adhesion_kinase	25,46	vascular endothelial growth factor	focal adhesion kinase	22339(Tax:10090)	14083(Tax:10090)	Gene	Gene	signaling|compound|START_ENTITY coupling|nmod|signaling coupling|nmod|beta5 beta5|amod|END_ENTITY	Src-mediated coupling of focal_adhesion_kinase to integrin alpha -LRB- v -RRB- beta5 in vascular_endothelial_growth_factor signaling .
19172544	0	vascular_endothelial_growth_factor	25,59	gonadotropin-releasing_hormone	66,96	vascular endothelial growth factor	gonadotropin-releasing hormone	7422	2796	Gene	Gene	START_ENTITY|nmod|treatment treatment|amod|END_ENTITY	Elevated level of plasma vascular_endothelial_growth_factor after gonadotropin-releasing_hormone agonist treatment for leiomyomata .
21477953	0	vascular_endothelial_growth_factor	70,104	hCG	108,111	vascular endothelial growth factor	hCG	281572(Tax:9913)	93659	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	Activation of PI3K/mTOR signaling pathway contributes to induction of vascular_endothelial_growth_factor by hCG in bovine developing luteal cells .
22859491	0	vascular_endothelial_growth_factor	109,143	heat-shock_protein_90	45,66	vascular endothelial growth factor	heat-shock protein 90	22339(Tax:10090)	104434(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Modulation of the cochaperone AHA1 regulates heat-shock_protein_90 and endothelial NO synthase activation by vascular_endothelial_growth_factor .
21854110	0	vascular_endothelial_growth_factor	106,140	heparin-binding_EGF-like_growth_factor	10,48	vascular endothelial growth factor	heparin-binding EGF-like growth factor	7422	1839	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of heparin-binding_EGF-like_growth_factor and amphiregulin on the MAP kinase-induced production of vascular_endothelial_growth_factor by human granulosa cells .
17091770	0	vascular_endothelial_growth_factor	64,98	heparin_affin_regulatory_peptide	10,42	vascular endothelial growth factor	heparin affin regulatory peptide	7422	5764	Gene	Gene	receptors|compound|START_ENTITY expression|nmod|receptors Effect|nmod|expression Effect|nmod|END_ENTITY	Effect of heparin_affin_regulatory_peptide on the expression of vascular_endothelial_growth_factor receptors in endothelial cells .
17908800	0	vascular_endothelial_growth_factor	145,179	heparin_affin_regulatory_peptide	187,219	vascular endothelial growth factor	heparin affin regulatory peptide	22339(Tax:10090)	19242(Tax:10090)	Gene	Gene	disruption|nmod|START_ENTITY matrix_metalloproteinase_2|dep|disruption processed|nmod|matrix_metalloproteinase_2 Identification|acl|processed Identification|parataxis|tissue_growth_factor tissue_growth_factor|nsubj|pleiotrophin pleiotrophin|amod|END_ENTITY	Identification of candidate angiogenic inhibitors processed by matrix_metalloproteinase_2 -LRB- MMP-2 -RRB- in cell-based proteomic screens : disruption of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / heparin_affin_regulatory_peptide -LRB- pleiotrophin -RRB- and VEGF/Connective _ tissue_growth_factor angiogenic inhibitory complexes by MMP-2 proteolysis .
11954744	0	vascular_endothelial_growth_factor	45,79	hepatocyte_growth_factor	6,30	vascular endothelial growth factor	hepatocyte growth factor	7422	3082	Gene	Gene	combined|nmod|START_ENTITY combined|nsubj|END_ENTITY	Serum hepatocyte_growth_factor combined with vascular_endothelial_growth_factor as a predictive indicator for the occurrence of coronary_artery_lesions in Kawasaki_disease .
9880507	0	vascular_endothelial_growth_factor	20,54	heterogeneous_nuclear_ribonucleoprotein_L	84,125	vascular endothelial growth factor	heterogeneous nuclear ribonucleoprotein L	7422	3191	Gene	Gene	stability|compound|START_ENTITY Regulation|nmod|stability Regulation|nmod|END_ENTITY	Regulation of human vascular_endothelial_growth_factor mRNA stability in hypoxia by heterogeneous_nuclear_ribonucleoprotein_L .
18644116	0	vascular_endothelial_growth_factor	14,48	homeodomain-interacting_protein_kinase-2	63,103	vascular endothelial growth factor	homeodomain-interacting protein kinase-2	7422	28996	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by homeodomain-interacting_protein_kinase-2 .
10607702	0	vascular_endothelial_growth_factor	38,72	hypoxia-inducible_factor-1	142,168	vascular endothelial growth factor	hypoxia-inducible factor-1	7422	3091	Gene	Gene	gene|compound|START_ENTITY element|nmod|gene mediates|nsubj|element mediates|parataxis|control control|nmod|activity activity|amod|END_ENTITY	Hypoxia response element of the human vascular_endothelial_growth_factor gene mediates transcriptional regulation by nitric_oxide : control of hypoxia-inducible_factor-1 activity by nitric_oxide .
16144942	0	vascular_endothelial_growth_factor	149,183	hypoxia-inducible_factor-1	212,238	vascular endothelial growth factor	hypoxia-inducible factor-1	7422	3091	Gene	Gene	secretion|compound|START_ENTITY independent|nsubj|secretion independent|nmod|regulation regulation|amod|END_ENTITY	Transcriptional profiling identifies altered intracellular labile iron homeostasis as a contributing factor to the toxicity of adaphostin : decreased vascular_endothelial_growth_factor secretion is independent of hypoxia-inducible_factor-1 regulation .
16682012	0	vascular_endothelial_growth_factor	20,54	hypoxia-inducible_factor-1	70,96	vascular endothelial growth factor	hypoxia-inducible factor-1	7422	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Adenosine modulates vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1 in human glioblastoma cells .
18339855	0	vascular_endothelial_growth_factor	124,158	hypoxia-inducible_factor-1	81,107	vascular endothelial growth factor	hypoxia-inducible factor-1	7422	3091	Gene	Gene	expression|compound|START_ENTITY induce|dobj|expression stabilizes|xcomp|induce stabilizes|xcomp|alpha alpha|dep|END_ENTITY	Kaposi 's _ sarcoma-associated_herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible_factor-1 alpha to induce vascular_endothelial_growth_factor expression .
22582814	0	vascular_endothelial_growth_factor	96,130	hypoxia-inducible_factor-1	16,42	vascular endothelial growth factor	hypoxia-inducible factor-1	7422	3091	Gene	Gene	expression|nmod|START_ENTITY suppresses|dobj|expression suppresses|nsubj|Transfection Transfection|nmod|oligodeoxynucleotides oligodeoxynucleotides|amod|END_ENTITY	Transfection of hypoxia-inducible_factor-1 decoy oligodeoxynucleotides suppresses expression of vascular_endothelial_growth_factor in oral squamous_cell_carcinoma cells .
11350893	0	vascular_endothelial_growth_factor	12,46	hypoxia-inducible_factor-1_alpha	90,122	vascular endothelial growth factor	hypoxia-inducible factor-1 alpha	7422	3091	Gene	Gene	production|compound|START_ENTITY Relation|nmod|production Relation|acl|END_ENTITY	Relation of vascular_endothelial_growth_factor production to expression and regulation of hypoxia-inducible_factor-1_alpha and hypoxia-inducible_factor-2_alpha in human bladder_tumors and cell lines .
12368217	0	vascular_endothelial_growth_factor	92,126	hypoxia-inducible_factor-1_alpha	45,77	vascular endothelial growth factor	hypoxia-inducible factor-1 alpha	7422	3091	Gene	Gene	gene|compound|START_ENTITY gene|amod|END_ENTITY	Esophageal ulceration triggers expression of hypoxia-inducible_factor-1_alpha and activates vascular_endothelial_growth_factor gene : implications for angiogenesis and ulcer_healing .
15806152	0	vascular_endothelial_growth_factor	159,193	hypoxia-inducible_factor-1_alpha	84,116	vascular endothelial growth factor	hypoxia-inducible factor-1 alpha	7422	3091	Gene	Gene	expression|compound|START_ENTITY inhibition|nmod|expression leading|nmod|inhibition reduces|xcomp|leading reduces|xcomp|END_ENTITY	The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible_factor-1_alpha , leading to transcriptional inhibition of vascular_endothelial_growth_factor expression .
21729202	0	vascular_endothelial_growth_factor	77,111	hypoxia-inducible_factor-1a	16,43	vascular endothelial growth factor	hypoxia-inducible factor-1a	7422	281814(Tax:9913)	Gene	Gene	regulation|nmod|START_ENTITY END_ENTITY|nmod|regulation	Contribution of hypoxia-inducible_factor-1a to transcriptional regulation of vascular_endothelial_growth_factor in bovine developing luteal cells .
22128293	0	vascular_endothelial_growth_factor	41,75	hypoxia-inducible_factor-1a	80,107	vascular endothelial growth factor	hypoxia-inducible factor-1a	7422	3091	Gene	Gene	START_ENTITY|nmod|cells cells|amod|END_ENTITY	Hypoxic stress simultaneously stimulates vascular_endothelial_growth_factor via hypoxia-inducible_factor-1a and inhibits stromal cell-derived factor-1 in human endometrial stromal cells .
24890366	0	vascular_endothelial_growth_factor	69,103	hypoxia-inducible_factor-1a	41,68	vascular endothelial growth factor	hypoxia-inducible factor-1a	7422	3091	Gene	Gene	expression|compound|START_ENTITY phosphatidylinositol_3-kinase|dep|expression END_ENTITY|dep|phosphatidylinositol_3-kinase	Gambogic_acid suppresses hypoxia-induced hypoxia-inducible_factor-1a / vascular_endothelial_growth_factor expression via inhibiting phosphatidylinositol_3-kinase / Akt/mammalian target protein of rapamycin pathway in multiple_myeloma cells .
25543905	0	vascular_endothelial_growth_factor	103,137	hypoxia-inducible_factor-1a	75,102	vascular endothelial growth factor	hypoxia-inducible factor-1a	7422	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Endostar inhibits hypoxia-induced cell proliferation and migration via the hypoxia-inducible_factor-1a / vascular_endothelial_growth_factor pathway in vitro .
16618748	0	vascular_endothelial_growth_factor	61,95	hypoxia-inducible_factor-1alpha	111,142	vascular endothelial growth factor	hypoxia-inducible factor-1alpha	7422	3091	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Brain-derived_neurotrophic_factor activation of TrkB induces vascular_endothelial_growth_factor expression via hypoxia-inducible_factor-1alpha in neuroblastoma cells .
11866451	0	vascular_endothelial_growth_factor	17,51	hypoxia-inducible_factor_1	60,86	vascular endothelial growth factor	hypoxia-inducible factor 1	7422	3091	Gene	Gene	mRNA|compound|START_ENTITY Stabilization|nmod|mRNA Stabilization|nmod|END_ENTITY	Stabilization of vascular_endothelial_growth_factor mRNA by hypoxia-inducible_factor_1 .
24347168	0	vascular_endothelial_growth_factor	163,197	hypoxia-inducible_factor_1	87,113	vascular endothelial growth factor	hypoxia-inducible factor 1	7422	3091	Gene	Gene	targets|nmod|START_ENTITY activity|nmod|targets activity|amod|END_ENTITY	Endoplasmic reticulum -LRB- ER -RRB- stress and hypoxia response pathways interact to potentiate hypoxia-inducible_factor_1 -LRB- HIF-1 -RRB- transcriptional activity on targets like vascular_endothelial_growth_factor -LRB- VEGF -RRB- .
8756616	0	vascular_endothelial_growth_factor	14,48	hypoxia-inducible_factor_1	71,97	vascular endothelial growth factor	hypoxia-inducible factor 1	7422	3091	Gene	Gene	gene|compound|START_ENTITY Activation|nmod|gene transcription|nsubj|Activation transcription|advcl|END_ENTITY	Activation of vascular_endothelial_growth_factor gene transcription by hypoxia-inducible_factor_1 .
10987301	0	vascular_endothelial_growth_factor	85,119	hypoxia-inducible_factor_1alpha	213,244	vascular endothelial growth factor	hypoxia-inducible factor 1alpha	7422	3091	Gene	Gene	START_ENTITY|nmod|kinase kinase|acl|acting acting|advcl|END_ENTITY	The Kaposi 's _ sarcoma-associated_herpes_virus G protein-coupled receptor up-regulates vascular_endothelial_growth_factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible_factor_1alpha .
11359907	0	vascular_endothelial_growth_factor	134,168	hypoxia-inducible_factor_1alpha	43,74	vascular endothelial growth factor	hypoxia-inducible factor 1alpha	7422	3091	Gene	Gene	expression|compound|START_ENTITY mechanism|nmod|expression synthesis|dep|mechanism synthesis|amod|END_ENTITY	HER2 -LRB- neu -RRB- signaling increases the rate of hypoxia-inducible_factor_1alpha -LRB- HIF-1alpha -RRB- synthesis : novel mechanism for HIF-1-mediated vascular_endothelial_growth_factor expression .
14678768	0	vascular_endothelial_growth_factor	63,97	hypoxia-inducible_factor_1alpha	14,45	vascular endothelial growth factor	hypoxia-inducible factor 1alpha	83785(Tax:10116)	29560(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of hypoxia-inducible_factor_1alpha and induction of vascular_endothelial_growth_factor in a rat neonatal_stroke model .
18305118	0	vascular_endothelial_growth_factor	64,98	hypoxia-inducible_factor_1alpha	13,44	vascular endothelial growth factor	hypoxia-inducible factor 1alpha	7422	3091	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|expression expression|amod|END_ENTITY	Induction of hypoxia-inducible_factor_1alpha gene expression by vascular_endothelial_growth_factor .
18476562	0	vascular_endothelial_growth_factor	47,81	hypoxia_inducible_factor-1_alpha	11,43	vascular endothelial growth factor	hypoxia inducible factor-1 alpha	7422	3091	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	-LSB- Effect of hypoxia_inducible_factor-1_alpha on vascular_endothelial_growth_factor expression in human tongue squamous_carcinoma cells -LRB- Tca8113 -RRB- under hypoxia -RSB- .
15914522	0	vascular_endothelial_growth_factor	28,62	insulin	10,17	vascular endothelial growth factor	insulin	7422	3630	Gene	Gene	START_ENTITY|nsubj|Effect Effect|nmod|END_ENTITY	Effect of insulin on plasma vascular_endothelial_growth_factor in children with new-onset diabetes .
10585594	0	vascular_endothelial_growth_factor	14,48	insulin-like_growth_factor-I	63,91	vascular endothelial growth factor	insulin-like growth factor-I	7422	3479	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by insulin-like_growth_factor-I in endometrial_adenocarcinoma cells .
18677403	0	vascular_endothelial_growth_factor	79,113	insulin-like_growth_factor-I	14,42	vascular endothelial growth factor	insulin-like growth factor-I	397157(Tax:9823)	397491(Tax:9823)	Gene	Gene	hormone|nmod|START_ENTITY hormone|compound|END_ENTITY	The effect of insulin-like_growth_factor-I , relaxin and luteinizing hormone on vascular_endothelial_growth_factor secretion by cultured endometrial stromal cells on different days of early pregnancy in pigs .
8910616	0	vascular_endothelial_growth_factor	13,47	insulin-like_growth_factor_1	51,79	vascular endothelial growth factor	insulin-like growth factor 1	7422	3479	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by insulin-like_growth_factor_1 in colorectal_carcinoma .
15781617	0	vascular_endothelial_growth_factor	65,99	insulin-like_growth_factor_I	23,51	vascular endothelial growth factor	insulin-like growth factor I	7422	3479	Gene	Gene	induction|nmod|START_ENTITY induction|compound|END_ENTITY	Activated Ras enhances insulin-like_growth_factor_I induction of vascular_endothelial_growth_factor in prostate epithelial cells .
8641174	0	vascular_endothelial_growth_factor	23,57	insulin-like_growth_factor_I	130,158	vascular endothelial growth factor	insulin-like growth factor I	7422	16000(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY induced|nsubj|expression induced|nmod|END_ENTITY	Enhanced expression of vascular_endothelial_growth_factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like_growth_factor_I .
9313759	0	vascular_endothelial_growth_factor	14,48	insulin-like_growth_factor_I	63,91	vascular endothelial growth factor	insulin-like growth factor I	7422	3479	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression by insulin-like_growth_factor_I .
14734476	0	vascular_endothelial_growth_factor	168,202	insulin-like_growth_factor_binding_protein-3	105,149	vascular endothelial growth factor	insulin-like growth factor binding protein-3	22339(Tax:10090)	16009(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY induction|nmod|END_ENTITY	In vivo suppression of hormone-refractory_prostate_cancer growth by inositol_hexaphosphate : induction of insulin-like_growth_factor_binding_protein-3 and inhibition of vascular_endothelial_growth_factor .
10698041	0	vascular_endothelial_growth_factor	44,78	interferon-gamma	11,27	vascular endothelial growth factor	interferon-gamma	7422	3458	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of interferon-gamma on secretion of vascular_endothelial_growth_factor by endometrial_stromal cells .
12816689	0	vascular_endothelial_growth_factor	20,54	interferon-gamma	103,119	vascular endothelial growth factor	interferon-gamma	7422	3458	Gene	Gene	expression|compound|START_ENTITY Down-regulation|nmod|expression SKOV3|nsubj|Down-regulation SKOV3|nmod|-RSB- -RSB-|amod|END_ENTITY	-LSB- Down-regulation of vascular_endothelial_growth_factor expression in ovarian_cancer cell line SKOV3 by interferon-gamma -RSB- .
18060618	0	vascular_endothelial_growth_factor	18,52	interferon-gamma	67,83	vascular endothelial growth factor	interferon-gamma	7422	3458	Gene	Gene	value|nmod|START_ENTITY combined|nsubj|value combined|nmod|END_ENTITY	Clinical value of vascular_endothelial_growth_factor combined with interferon-gamma in diagnosing malignant_pleural_effusion and tuberculous_pleural_effusion .
15455259	0	vascular_endothelial_growth_factor	13,47	interleukin-1	96,109	vascular endothelial growth factor	interleukin-1	7422	3552	Gene	Gene	stromelysin|compound|START_ENTITY Induction|nmod|stromelysin Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor and matrix_metalloproteinase-3 -LRB- stromelysin -RRB- by interleukin-1 in human articular chondrocytes and synoviocytes .
24531563	0	vascular_endothelial_growth_factor	53,87	interleukin-18	24,38	vascular endothelial growth factor	interleukin-18	7422	3606	Gene	Gene	correlated|xcomp|START_ENTITY correlated|nsubj|intravitreous intravitreous|amod|END_ENTITY	Increased intravitreous interleukin-18 correlated to vascular_endothelial_growth_factor in patients with active proliferative_diabetic_retinopathy .
10408390	0	vascular_endothelial_growth_factor	14,48	interleukin-1beta	85,102	vascular endothelial growth factor	interleukin-1beta	7422	3553	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression in human colon_cancer by interleukin-1beta .
12792892	0	vascular_endothelial_growth_factor	16,50	interleukin-1beta	107,124	vascular endothelial growth factor	interleukin-1beta	22339(Tax:10090)	16176(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY overexpressing|nsubj|Upregulation overexpressing|dobj|IL-1beta IL-1beta|amod|END_ENTITY	Upregulation of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in the retinas of transgenic_mice overexpressing interleukin-1beta -LRB- IL-1beta -RRB- in the lens and mice undergoing retinal_degeneration .
15349119	0	vascular_endothelial_growth_factor	14,48	interleukin-1beta	93,110	vascular endothelial growth factor	interleukin-1beta	7422	3553	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vascular_endothelial_growth_factor expression in human gastric_cancer cells by interleukin-1beta .
17302909	0	vascular_endothelial_growth_factor	27,61	interleukin-4	10,23	vascular endothelial growth factor	interleukin-4	7422	3565	Gene	Gene	production|compound|START_ENTITY Effect|nmod|production Effect|nmod|END_ENTITY	Effect of interleukin-4 on vascular_endothelial_growth_factor production in rheumatoid synovial fibroblasts .
25110587	0	vascular_endothelial_growth_factor	45,79	interleukin-6	8,21	vascular endothelial growth factor	interleukin-6	7422	3569	Gene	Gene	superior|xcomp|START_ENTITY superior|nsubj|levels levels|amod|END_ENTITY	Aqueous interleukin-6 levels are superior to vascular_endothelial_growth_factor in predicting therapeutic response to bevacizumab in age-related_macular_degeneration .
25151086	0	vascular_endothelial_growth_factor	99,133	interleukin-6	33,46	vascular endothelial growth factor	interleukin-6	7422	3569	Gene	Gene	induced-secretion|nmod|START_ENTITY suppresses|dep|induced-secretion suppresses|dep|END_ENTITY	Synthetic -LRB- + -RRB- - terrein suppresses interleukin-6 / soluble interleukin-6_receptor induced-secretion of vascular_endothelial_growth_factor in human gingival fibroblasts .
20156197	0	vascular_endothelial_growth_factor	16,50	interleukin-8	75,88	vascular endothelial growth factor	interleukin-8	281572(Tax:9913)	280828(Tax:9913)	Gene	Gene	Effect|appos|START_ENTITY Effect|nmod|expression expression|nmod|IL-8 IL-8|dep|END_ENTITY	Effect of VEGF -LRB- vascular_endothelial_growth_factor -RRB- on expression of IL-8 -LRB- interleukin-8 -RRB- , IL-1beta and their receptors in bovine theca cells .
20334899	0	vascular_endothelial_growth_factor	94,128	interleukin-8	130,143	vascular endothelial growth factor	interleukin-8	7422	3576	Gene	Gene	impulses|nmod|START_ENTITY impulses|dep|END_ENTITY	Expression of angiostatic platelet factor-4var / CXCL4L1 counterbalances angiogenic impulses of vascular_endothelial_growth_factor , interleukin-8 / CXCL8 , and stromal cell-derived factor 1/CXCL12 in esophageal and colorectal_cancer .
12771987	0	vascular_endothelial_growth_factor	84,118	interleukin_6	36,49	vascular endothelial growth factor	interleukin 6	7422	3569	Gene	Gene	value|nmod|START_ENTITY value|nmod|levels levels|nmod|levels levels|amod|END_ENTITY	Prognostic value of serum levels of interleukin_6 and of serum and plasma levels of vascular_endothelial_growth_factor in hormone-refractory metastatic breast_cancer patients .
15093584	0	vascular_endothelial_growth_factor	22,56	interleukin_6	138,151	vascular endothelial growth factor	interleukin 6	7422	3569	Gene	Gene	loop|nmod|START_ENTITY established|nsubjpass|loop established|nmod|cells cells|acl|generated generated|nmod|treatment treatment|nmod|END_ENTITY	An autocrine loop for vascular_endothelial_growth_factor is established in prostate_cancer cells generated after prolonged treatment with interleukin_6 .
16926250	0	vascular_endothelial_growth_factor	85,119	kinase_insert_domain_receptor	120,149	vascular endothelial growth factor	kinase insert domain receptor	7422	3791	Gene	Gene	proliferation|nmod|START_ENTITY stimulates|dobj|proliferation END_ENTITY|dep|stimulates	Pituitary_tumor_transforming_gene -LRB- PTTG -RRB- stimulates thyroid cell proliferation via a vascular_endothelial_growth_factor / kinase_insert_domain_receptor / inhibitor of DNA binding-3 autocrine pathway .
23393131	0	vascular_endothelial_growth_factor	63,97	kinase_insert_domain_receptor	116,145	vascular endothelial growth factor	kinase insert domain receptor	7422	3791	Gene	Gene	activation|amod|START_ENTITY activation|compound|END_ENTITY	Endothelial_cell-specific_chemotaxis_receptor -LRB- ECSCR -RRB- enhances vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-2 / kinase_insert_domain_receptor -LRB- KDR -RRB- activation and promotes proteolysis of internalized KDR .
19018001	0	vascular_endothelial_growth_factor	101,135	mTORC2	61,67	vascular endothelial growth factor	mTORC2	7422	74343(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	CD40-induced signaling in human endothelial cells results in mTORC2 - and Akt-dependent expression of vascular_endothelial_growth_factor in vitro and in vivo .
24829764	0	vascular_endothelial_growth_factor	38,72	matrix_metallopeptidase-9	74,99	vascular endothelial growth factor	matrix metallopeptidase-9	7422	4318	Gene	Gene	expressions|nmod|START_ENTITY expressions|amod|END_ENTITY	A multicenter study on expressions of vascular_endothelial_growth_factor , matrix_metallopeptidase-9 and tissue_inhibitor_of_metalloproteinase-2 in oral and maxillofacial_squamous_cell_carcinoma .
11606713	0	vascular_endothelial_growth_factor	127,161	matrix_metalloproteinase-9	80,106	vascular endothelial growth factor	matrix metalloproteinase-9	22339(Tax:10090)	17395(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|nmod|END_ENTITY	Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix_metalloproteinase-9 and mobilization of vascular_endothelial_growth_factor .
14530359	0	vascular_endothelial_growth_factor	95,129	matrix_metalloproteinase-9	17,43	vascular endothelial growth factor	matrix metalloproteinase-9	22339(Tax:10090)	17395(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY Up-regulation|dep|role Up-regulation|nmod|lymphocytes lymphocytes|amod|END_ENTITY	Up-regulation of matrix_metalloproteinase-9 in T lymphocytes of mammary_tumor bearers : role of vascular_endothelial_growth_factor .
16395286	0	vascular_endothelial_growth_factor	83,117	matrix_metalloproteinase-9	50,76	vascular endothelial growth factor	matrix metalloproteinase-9	22339(Tax:10090)	17395(Tax:10090)	Gene	Gene	hyperstimulation|compound|START_ENTITY effect|nmod|hyperstimulation effect|nmod|tetracyclines tetracyclines|nmod|END_ENTITY	Dose-response effect of tetracyclines on cerebral matrix_metalloproteinase-9 after vascular_endothelial_growth_factor hyperstimulation .
20682710	0	vascular_endothelial_growth_factor	144,178	microsomal_prostaglandin-E_synthase-1	106,143	vascular endothelial growth factor	microsomal prostaglandin-E synthase-1	7422	9536	Gene	Gene	expression|compound|START_ENTITY expression|amod|END_ENTITY	Inhibition of hypoxia_inducible_factor-1alpha by dihydroxyphenylethanol , a product from olive oil , blocks microsomal_prostaglandin-E_synthase-1 / vascular_endothelial_growth_factor expression and reduces tumor angiogenesis .
10842181	0	vascular_endothelial_growth_factor	37,71	neuropilin-1	19,31	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	The interaction of neuropilin-1 with vascular_endothelial_growth_factor and its receptor flt-1 .
12910515	0	vascular_endothelial_growth_factor	39,73	neuropilin-1	83,95	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|amod|END_ENTITY	Expression and regulation of the novel vascular_endothelial_growth_factor receptor neuropilin-1 by epidermal_growth_factor in human pancreatic_carcinoma .
15126502	0	vascular_endothelial_growth_factor	31,65	neuropilin-1	145,157	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	effects|nmod|START_ENTITY mediated|nsubjpass|effects mediated|nmod|production production|amod|END_ENTITY	Anti-chemorepulsive effects of vascular_endothelial_growth_factor and placental_growth_factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production .
15749672	0	vascular_endothelial_growth_factor	27,61	neuropilin-1	134,146	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	expression|nmod|START_ENTITY expression|dep|evidence evidence|dep|produced produced|nsubjpass|END_ENTITY	Differential expression of vascular_endothelial_growth_factor and its receptors in hematopoietic and fatty bone marrow : evidence that neuropilin-1 is produced by fat cells .
16371354	0	vascular_endothelial_growth_factor	83,117	neuropilin-1	14,26	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	exon|nmod|START_ENTITY encoded|nmod|exon that|acl|encoded similar|nmod|that sequence|amod|similar END_ENTITY|nmod|sequence	Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular_endothelial_growth_factor .
16513643	0	vascular_endothelial_growth_factor	101,135	neuropilin-1	39,51	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	exon|compound|START_ENTITY importance|nmod|exon reveals|dobj|importance reveals|nsubj|Characterization Characterization|nmod|antagonist antagonist|amod|END_ENTITY	Characterization of a bicyclic peptide neuropilin-1 -LRB- NP-1 -RRB- antagonist -LRB- EG3287 -RRB- reveals importance of vascular_endothelial_growth_factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling .
17942890	0	vascular_endothelial_growth_factor	88,122	neuropilin-1	143,155	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	The original Pathologische Anatomie Leiden-Endothelium monoclonal antibody recognizes a vascular_endothelial_growth_factor binding site within neuropilin-1 .
18715621	0	vascular_endothelial_growth_factor	15,49	neuropilin-1	87,99	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	levels|nmod|START_ENTITY levels|dep|VEGFR-1 VEGFR-1|dep|END_ENTITY	High levels of vascular_endothelial_growth_factor and its receptors -LRB- VEGFR-1 , VEGFR-2 , neuropilin-1 -RRB- are associated with worse outcome in breast_cancer .
18996601	0	vascular_endothelial_growth_factor	18,52	neuropilin-1	62,74	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|amod|END_ENTITY	Expression of the vascular_endothelial_growth_factor receptor neuropilin-1 in the human endometrium .
21111525	0	vascular_endothelial_growth_factor	18,52	neuropilin-1	62,74	vascular endothelial growth factor	neuropilin-1	7422	8829	Gene	Gene	receptor|compound|START_ENTITY Expression|nmod|receptor Expression|amod|END_ENTITY	Expression of the vascular_endothelial_growth_factor receptor neuropilin-1 at the human embryo-maternal interface .
20651020	0	vascular_endothelial_growth_factor	52,86	neuropilin-2	18,30	vascular endothelial growth factor	neuropilin-2	7422	8828	Gene	Gene	bioactivity|compound|START_ENTITY antagonizes|dobj|bioactivity antagonizes|nsubj|domain domain|amod|END_ENTITY	A mutated soluble neuropilin-2 B domain antagonizes vascular_endothelial_growth_factor bioactivity and inhibits tumor progression .
15165104	0	vascular_endothelial_growth_factor	36,70	nuclear_factor-kappa_B	10,32	vascular endothelial growth factor	nuclear factor-kappa B	7422	4790	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|nmod|expression	Effect of nuclear_factor-kappa_B on vascular_endothelial_growth_factor mRNA expression of human pulmonary artery smooth muscle cells in hypoxia .
9836530	0	vascular_endothelial_growth_factor	104,138	occludin	149,157	vascular endothelial growth factor	occludin	83785(Tax:10116)	83497(Tax:10116)	Gene	Gene	decreases|nsubj|START_ENTITY decreases|dobj|END_ENTITY	Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content : vascular_endothelial_growth_factor decreases occludin in retinal endothelial cells .
9836530	0	vascular_endothelial_growth_factor	104,138	occludin	86,94	vascular endothelial growth factor	occludin	83785(Tax:10116)	83497(Tax:10116)	Gene	Gene	decreases|nsubj|START_ENTITY associated|parataxis|decreases associated|nmod|content content|compound|END_ENTITY	Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content : vascular_endothelial_growth_factor decreases occludin in retinal endothelial cells .
14499864	0	vascular_endothelial_growth_factor	59,93	oncostatin-M	24,36	vascular endothelial growth factor	oncostatin-M	7422	5008	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Glycoprotein 130 ligand oncostatin-M induces expression of vascular_endothelial_growth_factor in human adult cardiac myocytes .
17269136	0	vascular_endothelial_growth_factor	40,74	oncostatin_M	11,23	vascular endothelial growth factor	oncostatin M	7422	5008	Gene	Gene	Effects|nmod|START_ENTITY Effects|nmod|END_ENTITY	Effects of oncostatin_M on secretion of vascular_endothelial_growth_factor and reconstruction of liver-like structure by fetal liver cells in monolayer and three-dimensional cultures .
10889466	0	vascular_endothelial_growth_factor	21,55	p38	97,100	vascular endothelial growth factor	p38	22339(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY induces|dobj|synthesis induces|parataxis|involvement involvement|nmod|kinase kinase|amod|END_ENTITY	Endothelin-1 induces vascular_endothelial_growth_factor synthesis in osteoblasts : involvement of p38 mitogen-activated protein kinase .
11245489	0	vascular_endothelial_growth_factor	17,51	p38	108,111	vascular endothelial growth factor	p38	22339(Tax:10090)	26416(Tax:10090)	Gene	Gene	START_ENTITY|nmod|cells cells|nmod|END_ENTITY	Up-regulation of vascular_endothelial_growth_factor in breast_cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration .
11524243	0	vascular_endothelial_growth_factor	110,144	p38	0,3	vascular endothelial growth factor	p38	22339(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|compound|START_ENTITY involved|nmod|synthesis involved|nsubjpass|protein protein|amod|END_ENTITY	p38 mitogen-activated protein -LRB- MAP -RRB- kinase but not p44/p42 MAP kinase is involved in prostaglandin_E1-induced vascular_endothelial_growth_factor synthesis in osteoblasts .
12482858	0	vascular_endothelial_growth_factor	89,123	p38	23,26	vascular endothelial growth factor	p38	7422	1432	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression kinase|nmod|induction kinase|nsubj|Evidence Evidence|nmod|role role|nmod|END_ENTITY	Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular_endothelial_growth_factor expression by sodium_arsenite .
15719130	0	vascular_endothelial_growth_factor	62,96	p38	0,3	vascular endothelial growth factor	p38	7422	5594	Gene	Gene	release|compound|START_ENTITY mediates|dobj|release mediates|nsubj|kinase kinase|nummod|END_ENTITY	p38 Mitogen-activated protein kinase mediates hypoxia-induced vascular_endothelial_growth_factor release in human endothelial cells .
16452201	0	vascular_endothelial_growth_factor	19,53	p38	83,86	vascular endothelial growth factor	p38	7422	1432	Gene	Gene	expression|compound|START_ENTITY expression|dep|correlation correlation|nmod|levels levels|amod|END_ENTITY	Heparanase induces vascular_endothelial_growth_factor expression : correlation with p38 phosphorylation levels and Src activation .
16595708	0	vascular_endothelial_growth_factor	43,77	p38	90,93	vascular endothelial growth factor	p38	22339(Tax:10090)	26416(Tax:10090)	Gene	Gene	synthesis|nmod|START_ENTITY stimulates|dobj|synthesis stimulates|nmod|mitogen mitogen|amod|END_ENTITY	Angiotensin_II stimulates the synthesis of vascular_endothelial_growth_factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytes .
23177780	0	vascular_endothelial_growth_factor	32,66	p38	79,82	vascular endothelial growth factor	p38	7422	1432	Gene	Gene	expression|nmod|START_ENTITY promotes|dobj|expression promotes|nmod|pathway pathway|amod|END_ENTITY	IL-6 promotes the expression of vascular_endothelial_growth_factor through the p38 signalling pathway in hypertrophied adenoids in children .
23401656	0	vascular_endothelial_growth_factor	27,61	p38	126,129	vascular endothelial growth factor	p38	7422	1432	Gene	Gene	secretion|compound|START_ENTITY Regulation|nmod|secretion Regulation|dep|cultures cultures|dep|END_ENTITY	Regulation of constitutive vascular_endothelial_growth_factor secretion in retinal_pigment_epithelium / choroid organ cultures : p38 , nuclear factor kB , and the vascular_endothelial_growth_factor receptor-2 / phosphatidylinositol 3 kinase pathway .
25132397	0	vascular_endothelial_growth_factor	104,138	p38	187,190	vascular endothelial growth factor	p38	22339(Tax:10090)	26416(Tax:10090)	Gene	Gene	process|compound|START_ENTITY upregulation|nmod|process upregulation|acl:relcl|has has|nsubj|kinase kinase|amod|END_ENTITY	Interleukin-4_and_granulocyte-macrophage_colony-stimulating_factor mediates the upregulation of soluble vascular_endothelial_growth_factor receptor-1 in RAW264 .7 cells-a process in which p38 mitogen-activated protein kinase signaling has an important role .
9393975	0	vascular_endothelial_growth_factor	29,63	p38	0,3	vascular endothelial growth factor	p38	7422	1432	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	p38 MAP kinase activation by vascular_endothelial_growth_factor mediates actin reorganization and cell migration in human endothelial cells .
10910082	0	vascular_endothelial_growth_factor	117,151	p53	10,13	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|compound|START_ENTITY suppression|nmod|expression angiogenesis|nmod|suppression angiogenesis|nsubj|suppresses suppresses|compound|END_ENTITY	Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial_sarcoma by transcriptional suppression of vascular_endothelial_growth_factor expression .
11280795	0	vascular_endothelial_growth_factor	18,52	p53	76,79	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|nmod|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	The expression of vascular_endothelial_growth_factor correlates with mutant p53 and poor prognosis in human breast_cancer .
11720743	0	vascular_endothelial_growth_factor	14,48	p53	112,115	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|association association|nmod|mutation mutation|compound|END_ENTITY	Expression of vascular_endothelial_growth_factor -LRB- VEGF -RRB- in non-small_cell_lung_cancer -LRB- NSCLC -RRB- : association with p53 gene mutation and prognosis .
11844810	0	vascular_endothelial_growth_factor	54,88	p53	9,12	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	mRNA|compound|START_ENTITY expression|nmod|mRNA correlates|nmod|expression correlates|nsubj|expression expression|compound|END_ENTITY	Aberrant p53 expression correlates with expression of vascular_endothelial_growth_factor mRNA and interleukin-8 mRNA and neoangiogenesis in non-small-cell_lung_cancer .
12460743	0	vascular_endothelial_growth_factor	120,154	p53	100,103	vascular endothelial growth factor	p53	83785(Tax:10116)	301300(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	The hepatic endothelial carcinogen riddelliine induces endothelial apoptosis , mitosis , S phase , and p53 and hepatocytic vascular_endothelial_growth_factor expression after short-term exposure .
12782015	0	vascular_endothelial_growth_factor	35,69	p53	10,13	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|compound|START_ENTITY transfection|nmod|expression transfection|nsubj|Effect Effect|nmod|gene gene|compound|END_ENTITY	Effect of p53 gene transfection on vascular_endothelial_growth_factor expression in endometrial_cancer cells .
12969230	0	vascular_endothelial_growth_factor	14,48	p53	98,101	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_endothelial_growth_factor in salivary_gland_carcinomas and its relation to p53 , Ki-67 and prognosis .
15142682	0	vascular_endothelial_growth_factor	45,79	p53	15,18	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|expression expression|compound|END_ENTITY	Correlation of p53 and bcl-2 expression with vascular_endothelial_growth_factor -LRB- VEGF -RRB- , microvessel density -LRB- MVD -RRB- and clinico-pathological features in colon_cancer .
15221598	0	vascular_endothelial_growth_factor	42,76	p53	30,33	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	Correlation|appos|START_ENTITY Correlation|nmod|END_ENTITY	Correlation and expression of p53 , HER-2 , vascular_endothelial_growth_factor -LRB- VEGF -RRB- , and e-cadherin in a high-risk breast-cancer population .
21324396	0	vascular_endothelial_growth_factor	13,47	p53	0,3	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|compound|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	p53 inhibits vascular_endothelial_growth_factor expression in solid tumor .
25225463	0	vascular_endothelial_growth_factor	59,93	p53	48,51	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	epidermal|dep|START_ENTITY epidermal|dep|END_ENTITY	Expression of epidermal_growth_factor_receptor , p53 , Bcl2 , vascular_endothelial_growth_factor , cyclooxygenase-2 , cyclin_D1 , human epidermal receptor-2 and Ki-67 : Association with clinicopathological profiles and outcomes in gallbladder_carcinoma .
26573068	0	vascular_endothelial_growth_factor	10,44	p53	67,70	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	siRNA|compound|START_ENTITY Effect|nmod|siRNA Effect|dep|type type|dep|co co|compound|END_ENTITY	Effect of vascular_endothelial_growth_factor siRNA and wild - type p53 co - expressing plasmid in MDA - MB -231 cells .
8108142	0	vascular_endothelial_growth_factor	53,87	p53	7,10	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|compound|START_ENTITY induction|nmod|expression potentiates|dobj|induction potentiates|nsubj|END_ENTITY	Mutant p53 potentiates protein_kinase_C induction of vascular_endothelial_growth_factor expression .
8521408	0	vascular_endothelial_growth_factor	59,93	p53	10,13	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	expression|compound|START_ENTITY influences|nmod|expression influences|nsubj|END_ENTITY	Wild-type p53 and v-Src exert opposing influences on human vascular_endothelial_growth_factor gene expression .
9377555	0	vascular_endothelial_growth_factor	58,92	p53	0,3	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	gene|compound|START_ENTITY transcription|nmod|gene repress|dobj|transcription repress|nsubj|END_ENTITY	p53 does not repress hypoxia-induced transcription of the vascular_endothelial_growth_factor gene .
9622060	0	vascular_endothelial_growth_factor	63,97	p53	30,33	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	START_ENTITY|nsubj|down-regulates down-regulates|compound|END_ENTITY	Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular_endothelial_growth_factor expression and inhibits angiogenesis in human colon_cancer .
9635853	0	vascular_endothelial_growth_factor	39,73	p53	93,96	vascular endothelial growth factor	p53	7422	7157	Gene	Gene	associated|nsubjpass|START_ENTITY associated|nmod|mutation mutation|compound|END_ENTITY	In oesophageal_squamous_cell_carcinoma vascular_endothelial_growth_factor is associated with p53 mutation , advanced stage and poor prognosis .
12482580	0	vascular_endothelial_growth_factor	24,58	p57	75,78	vascular endothelial growth factor	p57	22339(Tax:10090)	12721(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Increased expression of vascular_endothelial_growth_factor in placentas of p57 -LRB- Kip2 -RRB- null embryos .
23780896	0	vascular_endothelial_growth_factor	109,143	parathyroid_hormone-related_protein	25,60	vascular endothelial growth factor	parathyroid hormone-related protein	7422	5744	Gene	Gene	expression|amod|START_ENTITY related|nmod|expression related|nsubjpass|END_ENTITY	Paraneoplastic hormones : parathyroid_hormone-related_protein -LRB- PTHrP -RRB- and erythropoietin -LRB- EPO -RRB- are related to vascular_endothelial_growth_factor -LRB- VEGF -RRB- expression in clear_cell_renal_cell_carcinoma .
17008323	0	vascular_endothelial_growth_factor	24,58	phosphatidylinositol_3-kinase	114,143	vascular endothelial growth factor	phosphatidylinositol 3-kinase	7422	5293	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nmod|Akt Akt|amod|END_ENTITY	Ginsenoside-Rg1 induces vascular_endothelial_growth_factor expression through the glucocorticoid_receptor-related phosphatidylinositol_3-kinase / Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells .
19274678	0	vascular_endothelial_growth_factor	56,90	phosphatidylinositol_3-kinase	108,137	vascular endothelial growth factor	phosphatidylinositol 3-kinase	7422	5293	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Radix Astragali extract promotes angiogenesis involving vascular_endothelial_growth_factor receptor-related phosphatidylinositol_3-kinase / Akt-dependent pathway in human endothelial cells .
24890366	0	vascular_endothelial_growth_factor	69,103	phosphatidylinositol_3-kinase	130,159	vascular endothelial growth factor	phosphatidylinositol 3-kinase	7422	5290	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Gambogic_acid suppresses hypoxia-induced hypoxia-inducible_factor-1a / vascular_endothelial_growth_factor expression via inhibiting phosphatidylinositol_3-kinase / Akt/mammalian target protein of rapamycin pathway in multiple_myeloma cells .
11782462	0	vascular_endothelial_growth_factor	19,53	pigment_epithelium-derived_factor	75,108	vascular endothelial growth factor	pigment epithelium-derived factor	83785(Tax:10116)	287526(Tax:10116)	Gene	Gene	Down-regulation|nmod|START_ENTITY Down-regulation|nmod|END_ENTITY	Down-regulation of vascular_endothelial_growth_factor and up-regulation of pigment_epithelium-derived_factor : a possible mechanism for the anti-angiogenic activity of plasminogen kringle 5 .
12779248	0	vascular_endothelial_growth_factor	17,51	pigment_epithelium-derived_factor	75,108	vascular endothelial growth factor	pigment epithelium-derived factor	7422	57104	Gene	Gene	Up-regulation|nmod|START_ENTITY Up-regulation|nmod|levels levels|amod|END_ENTITY	Up-regulation of vascular_endothelial_growth_factor and down-regulation of pigment_epithelium-derived_factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes .
17908464	0	vascular_endothelial_growth_factor	119,153	pigment_epithelium-derived_factor	8,41	vascular endothelial growth factor	pigment epithelium-derived factor	7422	57104	Gene	Gene	induced|nmod|START_ENTITY Role|acl|induced Role|nmod|END_ENTITY	Role of pigment_epithelium-derived_factor on proliferation and migration of choroidal capillary endothelium induced by vascular_endothelial_growth_factor in vitro .
21707863	0	vascular_endothelial_growth_factor	144,178	pigment_epithelium-derived_factor	15,48	vascular endothelial growth factor	pigment epithelium-derived factor	7422	57104	Gene	Gene	expression|compound|START_ENTITY downregulating|dobj|expression enhances|advcl|downregulating enhances|nsubj|Combination Combination|nmod|END_ENTITY	Combination of pigment_epithelium-derived_factor with radiotherapy enhances the antitumor effects on nasopharyngeal_carcinoma by downregulating vascular_endothelial_growth_factor expression and angiogenesis .
25948043	0	vascular_endothelial_growth_factor	57,91	pigment_epithelium-derived_factor	12,45	vascular endothelial growth factor	pigment epithelium-derived factor	7422	57104	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|PEDF PEDF|compound|END_ENTITY	Recombinant pigment_epithelium-derived_factor PEDF binds vascular_endothelial_growth_factor receptors 1 and 2 .
14684734	0	vascular_endothelial_growth_factor	77,111	placental_growth_factor	25,48	vascular endothelial growth factor	placental growth factor	7422	5228	Gene	Gene	receptor-1|compound|START_ENTITY structure|nmod|receptor-1 structure|nmod|END_ENTITY	The crystal structure of placental_growth_factor in complex with domain 2 of vascular_endothelial_growth_factor receptor-1 .
15710418	0	vascular_endothelial_growth_factor	43,77	placental_growth_factor	16,39	vascular endothelial growth factor	placental growth factor	22339(Tax:10090)	18654(Tax:10090)	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|nmod|END_ENTITY	Upregulation of placental_growth_factor by vascular_endothelial_growth_factor via a post-transcriptional mechanism .
20145150	0	vascular_endothelial_growth_factor	54,88	placental_growth_factor	2,25	vascular endothelial growth factor	placental growth factor	7422	5228	Gene	Gene	receptor-1|nsubj|START_ENTITY recognize|xcomp|receptor-1 unable|xcomp|recognize variant|amod|unable variant|compound|END_ENTITY	A placental_growth_factor variant unable to recognize vascular_endothelial_growth_factor -LRB- VEGF -RRB- receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization .
21513467	0	vascular_endothelial_growth_factor	75,109	placental_growth_factor	6,29	vascular endothelial growth factor	placental growth factor	7422	5228	Gene	Gene	vascular_endothelial_growth_factor|appos|START_ENTITY END_ENTITY|appos|vascular_endothelial_growth_factor	Serum placental_growth_factor , vascular_endothelial_growth_factor , soluble vascular_endothelial_growth_factor receptor-1 and -2 levels in periodontal_disease , and adverse pregnancy outcomes .
22433027	0	vascular_endothelial_growth_factor	49,83	placental_growth_factor	24,47	vascular endothelial growth factor	placental growth factor	7422	5228	Gene	Gene	kinase|dep|START_ENTITY kinase|compound|END_ENTITY	Accuracy of circulating placental_growth_factor , vascular_endothelial_growth_factor , soluble fms-like tyrosine kinase 1 and soluble endoglin in the prediction of pre-eclampsia : a systematic review and meta-analysis .
18451337	0	vascular_endothelial_growth_factor	43,77	protein_tyrosine_phosphatase_1B	8,39	vascular endothelial growth factor	protein tyrosine phosphatase 1B	7422	5770	Gene	Gene	signaling|compound|START_ENTITY END_ENTITY|nmod|signaling	Role of protein_tyrosine_phosphatase_1B in vascular_endothelial_growth_factor signaling and cell-cell adhesions in endothelial cells .
20578818	0	vascular_endothelial_growth_factor	27,61	proteinase-activated_receptor-2	77,108	vascular endothelial growth factor	proteinase-activated receptor-2	7422	2150	Gene	Gene	expression|compound|START_ENTITY expression|nmod|kinase kinase|amod|END_ENTITY	beta-Tryptase up-regulates vascular_endothelial_growth_factor expression via proteinase-activated_receptor-2 and mitogen-activated protein kinase pathways in bone marrow stromal cells in acute_myeloid_leukemia .
15352169	0	vascular_endothelial_growth_factor	81,115	sFlt-1	46,52	vascular endothelial growth factor	sFlt-1	22339(Tax:10090)	14254(Tax:10090)	Gene	Gene	inhibitor|nmod|START_ENTITY END_ENTITY|appos|inhibitor	Post-transcriptional control of expression of sFlt-1 , an endogenous inhibitor of vascular_endothelial_growth_factor .
12213885	0	vascular_endothelial_growth_factor	98,132	thrombin	24,32	vascular endothelial growth factor	thrombin	7422	2147	Gene	Gene	expression|compound|START_ENTITY effects|nmod|expression effects|nmod|END_ENTITY	Differential effects of thrombin and hypoxia on endometrial stromal and glandular epithelial cell vascular_endothelial_growth_factor expression .
14517432	0	vascular_endothelial_growth_factor	28,62	thrombospondin	73,87	vascular endothelial growth factor	thrombospondin	7422	7057	Gene	Gene	Binding|nmod|START_ENTITY Binding|nmod|END_ENTITY	Binding and displacement of vascular_endothelial_growth_factor -LRB- VEGF -RRB- by thrombospondin : effect on human microvascular endothelial cell proliferation and angiogenesis .
12873985	0	vascular_endothelial_growth_factor	29,63	thrombospondin-1	115,131	vascular endothelial growth factor	thrombospondin-1	7422	7057	Gene	Gene	inhibition|nmod|START_ENTITY limits|nsubj|inhibition limits|nmod|END_ENTITY	SiRNA-mediated inhibition of vascular_endothelial_growth_factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth .
12963968	0	vascular_endothelial_growth_factor	68,102	thrombospondin-1	25,41	vascular endothelial growth factor	thrombospondin-1	7422	7057	Gene	Gene	relation|nmod|START_ENTITY significance|nmod|relation significance|nmod|expression expression|amod|END_ENTITY	Clinical significance of thrombospondin-1 expression in relation to vascular_endothelial_growth_factor and interleukin-10 expression at the deepest invasive tumor site of advanced colorectal_carcinoma .
21378271	0	vascular_endothelial_growth_factor	15,49	thrombospondin-1	71,87	vascular endothelial growth factor	thrombospondin-1	7422	7057	Gene	Gene	Priming|nmod|START_ENTITY Priming|acl|signaling signaling|nmod|END_ENTITY	Priming of the vascular_endothelial_growth_factor signaling pathway by thrombospondin-1 , CD36 , and spleen_tyrosine_kinase .
11061344	0	vascular_endothelial_growth_factor	27,61	thymidine_phosphorylase	66,89	vascular endothelial growth factor	thymidine phosphorylase	7422	1890	Gene	Gene	interactions|nmod|START_ENTITY interactions|nmod|END_ENTITY	Angiogenic interactions of vascular_endothelial_growth_factor , of thymidine_phosphorylase , and of p53 protein expression in locally advanced gastric_cancer .
15548809	0	vascular_endothelial_growth_factor	7,41	tie-2	93,98	vascular endothelial growth factor	tie-2	7422	7010	Gene	Gene	receptor|compound|START_ENTITY receptor|dep|END_ENTITY	Plasma vascular_endothelial_growth_factor , angiopoietin-2 , and soluble angiopoietin receptor tie-2 in diabetic_retinopathy : effects of laser photocoagulation and angiotensin receptor blockade .
9933439	0	vascular_endothelial_growth_factor	88,122	transforming_growth_factor-beta	27,58	vascular endothelial growth factor	transforming growth factor-beta	7422	7040	Gene	Gene	cytokine|dep|START_ENTITY cytokine|dep|TGF-beta TGF-beta|amod|END_ENTITY	Hypoxia augments cytokine -LRB- transforming_growth_factor-beta -LRB- TGF-beta -RRB- and IL-1 -RRB- - induced vascular_endothelial_growth_factor secretion by human synovial fibroblasts .
10526273	0	vascular_endothelial_growth_factor	102,136	transforming_growth_factor-beta1	18,50	vascular endothelial growth factor	transforming growth factor-beta1	7422	7040	Gene	Gene	expression|nmod|START_ENTITY correlated|nmod|expression correlated|nsubj|expression expression|nmod|END_ENTITY	The expression of transforming_growth_factor-beta1 is significantly correlated with the expression of vascular_endothelial_growth_factor and poor prognosis of patients with advanced gastric_carcinoma .
15504975	0	vascular_endothelial_growth_factor	17,51	transforming_growth_factor-beta1	114,146	vascular endothelial growth factor	transforming growth factor-beta1	22339(Tax:10090)	21803(Tax:10090)	Gene	Gene	mediates|nsubj|START_ENTITY mediates|nmod|END_ENTITY	Podocyte-derived vascular_endothelial_growth_factor mediates the stimulation of alpha3 -LRB- IV -RRB- collagen production by transforming_growth_factor-beta1 in mouse podocytes .
19553068	0	vascular_endothelial_growth_factor	82,116	tumor_necrosis_factor-alpha	32,59	vascular endothelial growth factor	tumor necrosis factor-alpha	7422	7124	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	JNK/AP -1 pathway is involved in tumor_necrosis_factor-alpha induced expression of vascular_endothelial_growth_factor in MCF7 cells .
8910439	0	vascular_endothelial_growth_factor	13,47	tumor_necrosis_factor_alpha	51,78	vascular endothelial growth factor	tumor necrosis factor alpha	7422	7124	Gene	Gene	Induction|nmod|START_ENTITY Induction|nmod|END_ENTITY	Induction of vascular_endothelial_growth_factor by tumor_necrosis_factor_alpha in human glioma cells .
16810742	0	vascular_endothelial_growth_factor	62,96	uPA	23,26	vascular endothelial growth factor	uPA	7422	5328	Gene	Gene	mRNA|nmod|START_ENTITY mRNA|compound|END_ENTITY	Correlative studies on uPA mRNA and uPAR mRNA expression with vascular_endothelial_growth_factor , microvessel density , progression and survival time of patients with gastric_cancer .
11950700	0	vascular_endothelial_growth_factor	137,171	vascular_endothelial_cadherin	64,93	vascular endothelial growth factor	vascular endothelial cadherin	7422	1003	Gene	Gene	signaling|amod|START_ENTITY control|dobj|signaling induces|advcl|control induces|nmod|END_ENTITY	Vascular_endothelial_growth_factor induces SHC association with vascular_endothelial_cadherin : a potential feedback mechanism to control vascular_endothelial_growth_factor receptor-2 signaling .
18180305	0	vascular_endothelial_growth_factor	105,139	vascular_endothelial_cadherin	16,45	vascular endothelial growth factor	vascular endothelial cadherin	7422	1003	Gene	Gene	activation|nmod|START_ENTITY modulating|dobj|activation END_ENTITY|acl|modulating	A novel role of vascular_endothelial_cadherin in modulating c-Src activation and downstream signaling of vascular_endothelial_growth_factor .
16139132	0	vascular_endothelial_growth_factor	10,44	vascular_endothelial_growth_factor	69,103	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	Increased vascular_endothelial_growth_factor expression but impaired vascular_endothelial_growth_factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary_heart_disease .
16139132	0	vascular_endothelial_growth_factor	69,103	vascular_endothelial_growth_factor	10,44	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Increased vascular_endothelial_growth_factor expression but impaired vascular_endothelial_growth_factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary_heart_disease .
18451229	0	vascular_endothelial_growth_factor	115,149	vascular_endothelial_growth_factor	68,102	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The effects of neoadjuvant anastrozole and tamoxifen on circulating vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor 1 in breast_cancer .
18451229	0	vascular_endothelial_growth_factor	68,102	vascular_endothelial_growth_factor	115,149	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	The effects of neoadjuvant anastrozole and tamoxifen on circulating vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor 1 in breast_cancer .
19828145	0	vascular_endothelial_growth_factor	108,142	vascular_endothelial_growth_factor	61,95	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Estrogen and selective estrogen receptor modulators regulate vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor 1 in human endometrial stromal cells .
19828145	0	vascular_endothelial_growth_factor	61,95	vascular_endothelial_growth_factor	108,142	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	receptor|compound|START_ENTITY receptor|compound|END_ENTITY	Estrogen and selective estrogen receptor modulators regulate vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor 1 in human endometrial stromal cells .
20026801	0	vascular_endothelial_growth_factor	182,216	vascular_endothelial_growth_factor	229,263	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|compound|START_ENTITY levels|amod|END_ENTITY	Phase I/II trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide , twice-weekly methotrexate , and daily prednisone as therapy for metastatic_breast_cancer using vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor levels as markers of response .
20026801	0	vascular_endothelial_growth_factor	229,263	vascular_endothelial_growth_factor	182,216	vascular endothelial growth factor	vascular endothelial growth factor	7422	7422	Gene	Gene	levels|amod|START_ENTITY levels|compound|END_ENTITY	Phase I/II trial of metronomic chemotherapy with daily dalteparin and cyclophosphamide , twice-weekly methotrexate , and daily prednisone as therapy for metastatic_breast_cancer using vascular_endothelial_growth_factor and soluble vascular_endothelial_growth_factor receptor levels as markers of response .
15667531	0	vascular_endothelial_growth_factor	49,83	vascular_permeability_factor	20,48	vascular endothelial growth factor	vascular permeability factor	7422	7422	Gene	Gene	role|dep|START_ENTITY role|nmod|END_ENTITY	The crucial role of vascular_permeability_factor / vascular_endothelial_growth_factor in angiogenesis : a historical review .
7688963	0	vascular_endothelial_growth_factor	16,50	vascular_permeability_factor	51,79	vascular endothelial growth factor	vascular permeability factor	7422	7422	Gene	Gene	Significance|nmod|START_ENTITY Significance|dep|END_ENTITY	Significance of vascular_endothelial_growth_factor / vascular_permeability_factor for solid tumor growth , and its inhibition by the antibody .
7775647	0	vascular_endothelial_growth_factor	53,87	vascular_permeability_factor	88,116	vascular endothelial growth factor	vascular permeability factor	7422	7422	Gene	Gene	expression|nmod|START_ENTITY expression|dep|END_ENTITY	Human chorionic gonadotropin-dependent expression of vascular_endothelial_growth_factor / vascular_permeability_factor in human granulosa cells : importance in ovarian_hyperstimulation_syndrome .
8442657	0	vascular_endothelial_growth_factor	44,78	vascular_permeability_factor	14,42	vascular endothelial growth factor	vascular permeability factor	7422	7422	Gene	Gene	Inhibition|appos|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of vascular_permeability_factor -LRB- vascular_endothelial_growth_factor -RRB- with antipeptide antibodies .
8476026	0	vascular_endothelial_growth_factor	43,77	vascular_permeability_factor	14,42	vascular endothelial growth factor	vascular permeability factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_permeability_factor / vascular_endothelial_growth_factor in normal rat tissues .
8527159	0	vascular_endothelial_growth_factor	27,61	vascular_permeability_factor	63,91	vascular endothelial growth factor	vascular permeability factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Differential expression of vascular_endothelial_growth_factor -LRB- vascular_permeability_factor -RRB- forms in rat tissues .
8548760	0	vascular_endothelial_growth_factor	43,77	vascular_permeability_factor	14,42	vascular endothelial growth factor	vascular permeability factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_permeability_factor / vascular_endothelial_growth_factor by melanoma cells increases_tumor growth , angiogenesis , and experimental metastasis .
8674055	0	vascular_endothelial_growth_factor	43,77	vascular_permeability_factor	14,42	vascular endothelial growth factor	vascular permeability factor	7422	7422	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of vascular_permeability_factor / vascular_endothelial_growth_factor in human hepatocellular_carcinoma .
9568844	0	vascular_endothelial_growth_factor	11,45	vascular_permeability_factor	53,81	vascular endothelial growth factor	vascular permeability factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|END_ENTITY	Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / vascular_permeability_factor -LRB- VPF -RRB- on haemodynamics and permselectivity of the isolated perfused rat kidney .
9698042	0	vascular_endothelial_growth_factor	27,61	vascular_permeability_factor	69,97	vascular endothelial growth factor	vascular permeability factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|dep|END_ENTITY	Inhibition by tranilast of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / vascular_permeability_factor -LRB- VPF -RRB- - induced increase in vascular permeability in rats .
9804359	0	vascular_endothelial_growth_factor	23,57	vascular_permeability_factor	58,86	vascular endothelial growth factor	vascular permeability factor	7422	7422	Gene	Gene	production|dep|START_ENTITY production|compound|END_ENTITY	Retinoids downregulate vascular_endothelial_growth_factor / vascular_permeability_factor production by normal human keratinocytes .
15569457	0	vascular_endothelial_growth_factor	54,88	von_Hippel-Lindau	13,30	vascular endothelial growth factor	von Hippel-Lindau	7422	7428	Gene	Gene	gene|nmod|START_ENTITY gene|amod|END_ENTITY	-LSB- Mutation of von_Hippel-Lindau gene and expression of vascular_endothelial_growth_factor in sporadic_clear_cell_renal_cell_carcinoma and their relationships to angiogenesis -RSB- .
23831623	0	vascular_endothelial_growth_factor-A	69,105	Aromatic_hydrocarbon_receptor	0,29	vascular endothelial growth factor-A	Aromatic hydrocarbon receptor	7422	196	Gene	Gene	expression|amod|START_ENTITY inhibits|dobj|expression inhibits|nsubj|END_ENTITY	Aromatic_hydrocarbon_receptor inhibits lysophosphatidic_acid-induced vascular_endothelial_growth_factor-A expression in PC-3_prostate_cancer cells .
18379992	0	vascular_endothelial_growth_factor-A	16,52	CD147	0,5	vascular endothelial growth factor-A	CD147	22339(Tax:10090)	12215(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	CD147 regulates vascular_endothelial_growth_factor-A expression , tumorigenicity , and chemosensitivity to curcumin in hepatocellular_carcinoma .
14962807	0	vascular_endothelial_growth_factor-A	46,82	Endothelin-1	0,12	vascular endothelial growth factor-A	Endothelin-1	83785(Tax:10116)	24323(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY down-regulates|dobj|expression down-regulates|nsubj|END_ENTITY	Endothelin-1 down-regulates the expression of vascular_endothelial_growth_factor-A associated with osteoprogenitor proliferation and differentiation .
22943069	0	vascular_endothelial_growth_factor-A	36,72	LL37	22,26	vascular endothelial growth factor-A	LL37	7422	820	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Antimicrobial peptide LL37 promotes vascular_endothelial_growth_factor-A expression in human periodontal ligament cells .
15123463	0	vascular_endothelial_growth_factor-A	72,108	Squamous_cell_carcinoma_related_oncogene	0,40	vascular endothelial growth factor-A	Squamous cell carcinoma related oncogene	7422	54165	Gene	Gene	regulates|nmod|START_ENTITY regulates|nsubj|END_ENTITY	Squamous_cell_carcinoma_related_oncogene regulates angiogenesis through vascular_endothelial_growth_factor-A .
16312046	0	vascular_endothelial_growth_factor-A	82,118	VEGF-A	120,126	vascular endothelial growth factor-A	VEGF-A	7422	7422	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Effects of human breast stromal cells on conjugated linoleic_acid -LRB- CLA -RRB- modulated vascular_endothelial_growth_factor-A -LRB- VEGF-A -RRB- expression in MCF-7 cells .
18261732	0	vascular_endothelial_growth_factor-A	27,63	VEGF-A	65,71	vascular endothelial growth factor-A	VEGF-A	7422	7422	Gene	Gene	association|nmod|START_ENTITY association|appos|END_ENTITY	Prospective association of vascular_endothelial_growth_factor-A -LRB- VEGF-A -RRB- with coronary_heart_disease mortality in southeastern New England .
26840372	0	vascular_endothelial_growth_factor-A	86,122	microRNA-497	0,12	vascular endothelial growth factor-A	microRNA-497	7422	574456	Gene	Gene	targeting|dobj|START_ENTITY inhibits|advcl|targeting inhibits|nsubj|END_ENTITY	microRNA-497 inhibits invasion and metastasis of colorectal_cancer cells by targeting vascular_endothelial_growth_factor-A .
10666423	0	vascular_endothelial_growth_factor-B	17,53	Vegfb	60,65	vascular endothelial growth factor-B	Vegfb	22340(Tax:10090)	22340(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mice lacking the vascular_endothelial_growth_factor-B gene -LRB- Vegfb -RRB- have smaller hearts , dysfunctional coronary vasculature , and impaired recovery from cardiac_ischemia .
17216674	0	vascular_endothelial_growth_factor-C	36,72	Tumor_necrosis_factor-alpha	0,27	vascular endothelial growth factor-C	Tumor necrosis factor-alpha	7424	7124	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha induces vascular_endothelial_growth_factor-C expression in rheumatoid synoviocytes .
11437102	0	vascular_endothelial_growth_factor-C	25,61	VEGF-C	63,69	vascular endothelial growth factor-C	VEGF-C	7424	7424	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	Clinical significance of vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- in breast_cancer .
14613645	0	vascular_endothelial_growth_factor-C	32,68	VEGF-C	70,76	vascular endothelial growth factor-C	VEGF-C	7424	7424	Gene	Gene	Significance|nmod|START_ENTITY Significance|appos|END_ENTITY	-LSB- Significance and expression of vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- in esophageal_squamous_carcinoma and glioma -RSB- .
18383841	0	vascular_endothelial_growth_factor-C	19,55	VEGF-C	57,63	vascular endothelial growth factor-C	VEGF-C	7424	7424	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Preoperative serum vascular_endothelial_growth_factor-C -LRB- VEGF-C -RRB- levels predict recurrence in patients with esophageal_cancer .
24744435	0	vascular_endothelial_growth_factor-C	29,65	VEGFC	72,77	vascular endothelial growth factor-C	VEGFC	7424	7424	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A novel stop mutation in the vascular_endothelial_growth_factor-C gene -LRB- VEGFC -RRB- results in Milroy-like_disease .
15713437	0	vascular_endothelial_growth_factor-C	77,113	hypoxia_inducible_factor-1alpha	15,46	vascular endothelial growth factor-C	hypoxia inducible factor-1alpha	7424	3091	Gene	Gene	Correlation|nmod|START_ENTITY Correlation|nmod|END_ENTITY	Correlation of hypoxia_inducible_factor-1alpha with lymphatic metastasis via vascular_endothelial_growth_factor-C in human esophageal_cancer .
17404025	0	vascular_endothelial_growth_factor-D	8,44	IL-6	57,61	vascular endothelial growth factor-D	IL-6	360457(Tax:10116)	24498(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|expression expression|compound|END_ENTITY	Role of vascular_endothelial_growth_factor-D -LRB- VEGF-D -RRB- on IL-6 expression in cerulein-stimulated pancreatic acinar cells .
17404025	0	vascular_endothelial_growth_factor-D	8,44	VEGF-D	46,52	vascular endothelial growth factor-D	VEGF-D	360457(Tax:10116)	360457(Tax:10116)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of vascular_endothelial_growth_factor-D -LRB- VEGF-D -RRB- on IL-6 expression in cerulein-stimulated pancreatic acinar cells .
19618119	0	vascular_endothelial_growth_factor_A	62,98	PAX6	0,4	vascular endothelial growth factor A	PAX6	7422	5080	Gene	Gene	suppression|nmod|START_ENTITY suppression|compound|END_ENTITY	PAX6 suppression of glioma angiogenesis and the expression of vascular_endothelial_growth_factor_A .
24138811	0	vascular_endothelial_growth_factor_A	56,92	VEGF-A	94,100	vascular endothelial growth factor A	VEGF-A	7422	7422	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	The relationship between lymphatic vascular density and vascular_endothelial_growth_factor_A -LRB- VEGF-A -RRB- expression with clinical-pathological features and survival in pancreatic_adenocarcinomas .
22429695	0	vascular_endothelial_growth_factor_A	20,56	VEGFA	58,63	vascular endothelial growth factor A	VEGFA	7422	7422	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Polymorphism in the vascular_endothelial_growth_factor_A -LRB- VEGFA -RRB- gene is associated with serum VEGF-A level and disease activity in rheumatoid_arthritis : differential effect of cigarette smoking .
22776467	0	vascular_endothelial_growth_factor_A	76,112	VEGFA	113,118	vascular endothelial growth factor A	VEGFA	7422	7422	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Age at onset of rheumatoid_arthritis : association with polymorphisms in the vascular_endothelial_growth_factor_A -LRB- VEGFA -RRB- gene and an intergenic locus between matrix_metalloproteinase _ -LRB- MMP -RRB- _ 1_and_3 genes .
18356031	0	vascular_endothelial_growth_factor_A	34,70	VEGFR1	98,104	vascular endothelial growth factor A	VEGFR1	7422	2321	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Immunohistochemical expression of vascular_endothelial_growth_factor_A -LRB- VEGF -RRB- , and its receptors -LRB- VEGFR1 , 2 -RRB- in normal and pathologic conditions of the human thymus .
23786956	0	vascular_endothelial_growth_factor_A	126,162	hypoxia_inducible_factor_1	99,125	vascular endothelial growth factor A	hypoxia inducible factor 1	7422	3091	Gene	Gene	pathway|compound|START_ENTITY pathway|dep|END_ENTITY	Chronic intermittent_hypoxia increases b cell mass and activates the mammalian_target_of_rapamycin / hypoxia_inducible_factor_1 / vascular_endothelial_growth_factor_A pathway in mice pancreatic islet .
23786956	0	vascular_endothelial_growth_factor_A	126,162	mammalian_target_of_rapamycin	69,98	vascular endothelial growth factor A	mammalian target of rapamycin	7422	2475	Gene	Gene	pathway|compound|START_ENTITY pathway|amod|END_ENTITY	Chronic intermittent_hypoxia increases b cell mass and activates the mammalian_target_of_rapamycin / hypoxia_inducible_factor_1 / vascular_endothelial_growth_factor_A pathway in mice pancreatic islet .
26398444	0	vascular_endothelial_growth_factor_A	63,99	miR-125a	0,8	vascular endothelial growth factor A	miR-125a	7422	406910	Gene	Gene	targeting|dobj|START_ENTITY regulates|advcl|targeting regulates|nsubj|END_ENTITY	miR-125a regulates angiogenesis of gastric_cancer by targeting vascular_endothelial_growth_factor_A .
18544126	0	vascular_endothelial_growth_factor_A	13,49	vascular_endothelial_growth_factor_A	144,180	vascular endothelial growth factor A	vascular endothelial growth factor A	7422	7422	Gene	Gene	expression|compound|START_ENTITY correlates|nsubj|expression correlates|nmod|END_ENTITY	Differential vascular_endothelial_growth_factor_A protein expression between small hepatocellular_carcinoma and cirrhosis correlates with serum vascular_endothelial_growth_factor_A and alpha-fetoprotein .
18544126	0	vascular_endothelial_growth_factor_A	144,180	vascular_endothelial_growth_factor_A	13,49	vascular endothelial growth factor A	vascular endothelial growth factor A	7422	7422	Gene	Gene	correlates|nmod|START_ENTITY correlates|nsubj|expression expression|compound|END_ENTITY	Differential vascular_endothelial_growth_factor_A protein expression between small hepatocellular_carcinoma and cirrhosis correlates with serum vascular_endothelial_growth_factor_A and alpha-fetoprotein .
15040017	0	vascular_endothelial_growth_factor_C	14,50	CCR7	74,78	vascular endothelial growth factor C	CCR7	7424	1236	Gene	Gene	receptor|amod|START_ENTITY Expression|nmod|receptor END_ENTITY|nsubj|Expression	Expression of vascular_endothelial_growth_factor_C and chemokine receptor CCR7 in gastric_carcinoma and their values in predicting lymph_node_metastasis .
22023263	0	vascular_endothelial_growth_factor_C	20,56	CYR61	0,5	vascular endothelial growth factor C	CYR61	7424	3491	Gene	Gene	expression|amod|START_ENTITY modulates|dobj|expression modulates|nsubj|END_ENTITY	CYR61 modulates the vascular_endothelial_growth_factor_C expression of decidual NK cells via PI3K/AKT pathway .
14966375	0	vascular_endothelial_growth_factor_C	68,104	NF-kappa_B	119,129	vascular endothelial growth factor C	NF-kappa B	7424	4790	Gene	Gene	START_ENTITY|advcl|activating activating|dobj|END_ENTITY	Overexpression of Her-2 / NEU in epithelial_ovarian_carcinoma induces vascular_endothelial_growth_factor_C by activating NF-kappa_B : implications for malignant ascites formation and tumor lymphangiogenesis .
12209971	0	vascular_endothelial_growth_factor_receptor	62,105	Autocrine_motility_factor	0,25	vascular endothelial growth factor receptor	Autocrine motility factor	3791	2821	Gene	Gene	expression|amod|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Autocrine_motility_factor secreted by tumor cells upregulates vascular_endothelial_growth_factor_receptor -LRB- Flt-1 -RRB- expression in endothelial cells .
12209971	0	vascular_endothelial_growth_factor_receptor	62,105	Flt-1	107,112	vascular endothelial growth factor receptor	Flt-1	3791	2321	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Autocrine_motility_factor secreted by tumor cells upregulates vascular_endothelial_growth_factor_receptor -LRB- Flt-1 -RRB- expression in endothelial cells .
21719570	0	vascular_endothelial_growth_factor_receptor	27,70	VEGFR	72,77	vascular endothelial growth factor receptor	VEGFR	3791	3791	Gene	Gene	levels|nmod|START_ENTITY levels|appos|END_ENTITY	Vitreous levels of soluble vascular_endothelial_growth_factor_receptor -LRB- VEGFR -RRB- -1 in eyes with vitreoretinal_diseases .
25424874	0	vascular_endothelial_growth_factor_receptor	24,67	VEGFR2	16,22	vascular endothelial growth factor receptor	VEGFR2	3791	3791	Gene	Gene	inhibitors|appos|START_ENTITY inhibitors|compound|END_ENTITY	Quantitation of VEGFR2 -LRB- vascular_endothelial_growth_factor_receptor -RRB- inhibitors - review of assay methodologies and perspectives .
19179362	0	vascular_endothelial_growth_factor_receptor-2	42,87	Fut8	15,19	vascular endothelial growth factor receptor-2	Fut8	16542(Tax:10090)	53618(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY END_ENTITY|nmod|expression	Requirement of Fut8 for the expression of vascular_endothelial_growth_factor_receptor-2 : a new mechanism for the emphysema-like changes observed in Fut8-deficient mice .
9705358	0	vascular_endothelial_growth_factor_receptor-2	52,97	Tumor_necrosis_factor-alpha	0,27	vascular endothelial growth factor receptor-2	Tumor necrosis factor-alpha	3791	7124	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells regulates|dobj|expression regulates|nsubj|END_ENTITY	Tumor_necrosis_factor-alpha regulates expression of vascular_endothelial_growth_factor_receptor-2 and of its co-receptor neuropilin-1 in human vascular endothelial cells .
19540581	0	vascular_endothelial_growth_factor_receptor-2	23,68	VEGFR-2	70,77	vascular endothelial growth factor receptor-2	VEGFR-2	3791	3791	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	The phosphorylation of vascular_endothelial_growth_factor_receptor-2 -LRB- VEGFR-2 -RRB- by engineered surfaces with electrostatically or covalently immobilized VEGF .
17702981	0	vascular_endothelial_growth_factor_receptor-2	21,66	flk1	81,85	vascular endothelial growth factor receptor-2	flk1	16542(Tax:10090)	16542(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	Lentiviral rescue of vascular_endothelial_growth_factor_receptor-2 expression in flk1 - / - embryonic stem cells shows early priming of endothelial precursors .
14716745	0	vascular_endothelial_growth_factor_receptor-3	14,59	VEGFR-3	61,68	vascular endothelial growth factor receptor-3	VEGFR-3	2324	2324	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_factor_receptor-3 -LRB- VEGFR-3 -RRB- in human prostate .
24710631	0	vascular_endothelial_growth_factor_receptor-3	21,66	VEGFR3	68,74	vascular endothelial growth factor receptor-3	VEGFR3	2324	2324	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Transcription of the vascular_endothelial_growth_factor_receptor-3 -LRB- VEGFR3 -RRB- gene is regulated by the zinc finger proteins Sp1 and Sp3 and is under epigenetic control : transcription of vascular endothelial growth factor receptor 3 .
26714823	0	vascular_endothelial_growth_factor_receptor_2	27,72	Serum_amyloid_A	0,15	vascular endothelial growth factor receptor 2	Serum amyloid A	3791	6287	Gene	Gene	expression|amod|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	Serum_amyloid_A stimulates vascular_endothelial_growth_factor_receptor_2 expression and angiogenesis .
20150621	0	vascular_endothelial_growth_inhibitor	14,51	VEGI	53,57	vascular endothelial growth inhibitor	VEGI	9966	9966	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vascular_endothelial_growth_inhibitor -LRB- VEGI -RRB- in human urothelial_cancer_of_the_bladder and its effects on the adhesion and migration of bladder_cancer cells in vitro .
16162438	0	vascular_endothelial_zinc_finger_1	44,78	Metallothionein_1	0,17	vascular endothelial zinc finger 1	Metallothionein 1	7716	644314	Gene	Gene	target|nmod|START_ENTITY target|nsubj|END_ENTITY	Metallothionein_1 is a downstream target of vascular_endothelial_zinc_finger_1 -LRB- VEZF1 -RRB- in endothelial cells and participates in the regulation of angiogenesis .
23845873	0	vascular_endothelium_growth_factor	96,130	Pim-3	0,5	vascular endothelium growth factor	Pim-3	7422	415116	Gene	Gene	promotes|nmod|START_ENTITY promotes|nsubj|END_ENTITY	Pim-3 promotes the growth of human pancreatic_cancer in the orthotopic nude mouse model through vascular_endothelium_growth_factor .
7737726	0	vascular_permeability_factor	25,53	Angiotensin_II	0,14	vascular permeability factor	Angiotensin II	7422	183	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Angiotensin_II increases vascular_permeability_factor gene expression by human vascular smooth muscle cells .
9041534	0	vascular_permeability_factor	24,52	Interleukin_10	0,14	vascular permeability factor	Interleukin 10	7422	3586	Gene	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Interleukin_10 inhibits vascular_permeability_factor release by peripheral blood mononuclear cells in patients with lipoid_nephrosis .
11244304	0	vascular_permeability_factor	42,70	Transforming_growth_factor-beta1	0,32	vascular permeability factor	Transforming growth factor-beta1	7422	7040	Gene	Gene	release|compound|START_ENTITY inhibits|dobj|release inhibits|nsubj|END_ENTITY	Transforming_growth_factor-beta1 inhibits vascular_permeability_factor release by T cells in normal subjects and in patients with minimal-change nephrotic_syndrome .
11162543	0	vascular_permeability_factor	16,44	VEGF	0,4	vascular permeability factor	VEGF	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	act|nmod|START_ENTITY act|nsubj|END_ENTITY	VEGF can act as vascular_permeability_factor in the hepatic sinusoids through upregulation of porosity of endothelial cells .
12213803	0	vascular_permeability_factor	52,80	vascular_endothelial_cell_growth_factor	12,51	vascular permeability factor	vascular endothelial cell growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	signaling|nsubj|START_ENTITY END_ENTITY|parataxis|signaling	Deciphering vascular_endothelial_cell_growth_factor / vascular_permeability_factor signaling to vascular permeability .
15667531	0	vascular_permeability_factor	20,48	vascular_endothelial_growth_factor	49,83	vascular permeability factor	vascular endothelial growth factor	7422	7422	Gene	Gene	role|nmod|START_ENTITY role|dep|END_ENTITY	The crucial role of vascular_permeability_factor / vascular_endothelial_growth_factor in angiogenesis : a historical review .
7688963	0	vascular_permeability_factor	51,79	vascular_endothelial_growth_factor	16,50	vascular permeability factor	vascular endothelial growth factor	7422	7422	Gene	Gene	Significance|dep|START_ENTITY Significance|nmod|END_ENTITY	Significance of vascular_endothelial_growth_factor / vascular_permeability_factor for solid tumor growth , and its inhibition by the antibody .
7775647	0	vascular_permeability_factor	88,116	vascular_endothelial_growth_factor	53,87	vascular permeability factor	vascular endothelial growth factor	7422	7422	Gene	Gene	expression|dep|START_ENTITY expression|nmod|END_ENTITY	Human chorionic gonadotropin-dependent expression of vascular_endothelial_growth_factor / vascular_permeability_factor in human granulosa cells : importance in ovarian_hyperstimulation_syndrome .
8442657	0	vascular_permeability_factor	14,42	vascular_endothelial_growth_factor	44,78	vascular permeability factor	vascular endothelial growth factor	7422	7422	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vascular_permeability_factor -LRB- vascular_endothelial_growth_factor -RRB- with antipeptide antibodies .
8476026	0	vascular_permeability_factor	14,42	vascular_endothelial_growth_factor	43,77	vascular permeability factor	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of vascular_permeability_factor / vascular_endothelial_growth_factor in normal rat tissues .
8527159	0	vascular_permeability_factor	63,91	vascular_endothelial_growth_factor	27,61	vascular permeability factor	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	expression|appos|START_ENTITY expression|nmod|END_ENTITY	Differential expression of vascular_endothelial_growth_factor -LRB- vascular_permeability_factor -RRB- forms in rat tissues .
8548760	0	vascular_permeability_factor	14,42	vascular_endothelial_growth_factor	43,77	vascular permeability factor	vascular endothelial growth factor	22339(Tax:10090)	22339(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of vascular_permeability_factor / vascular_endothelial_growth_factor by melanoma cells increases_tumor growth , angiogenesis , and experimental metastasis .
8674055	0	vascular_permeability_factor	14,42	vascular_endothelial_growth_factor	43,77	vascular permeability factor	vascular endothelial growth factor	7422	7422	Gene	Gene	Expression|nmod|START_ENTITY Expression|dep|END_ENTITY	Expression of vascular_permeability_factor / vascular_endothelial_growth_factor in human hepatocellular_carcinoma .
9568844	0	vascular_permeability_factor	53,81	vascular_endothelial_growth_factor	11,45	vascular permeability factor	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Effects|dep|START_ENTITY Effects|nmod|END_ENTITY	Effects of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / vascular_permeability_factor -LRB- VPF -RRB- on haemodynamics and permselectivity of the isolated perfused rat kidney .
9698042	0	vascular_permeability_factor	69,97	vascular_endothelial_growth_factor	27,61	vascular permeability factor	vascular endothelial growth factor	83785(Tax:10116)	83785(Tax:10116)	Gene	Gene	Inhibition|dep|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition by tranilast of vascular_endothelial_growth_factor -LRB- VEGF -RRB- / vascular_permeability_factor -LRB- VPF -RRB- - induced increase in vascular permeability in rats .
9804359	0	vascular_permeability_factor	58,86	vascular_endothelial_growth_factor	23,57	vascular permeability factor	vascular endothelial growth factor	7422	7422	Gene	Gene	production|compound|START_ENTITY production|dep|END_ENTITY	Retinoids downregulate vascular_endothelial_growth_factor / vascular_permeability_factor production by normal human keratinocytes .
24556843	0	vascular_peroxidase-1	106,127	JNK	133,136	vascular peroxidase-1	JNK	7837	5599	Gene	Gene	START_ENTITY|nmod|manner manner|compound|END_ENTITY	Activation of a7_nicotinic_acetylcholine_receptor protects against oxidant stress damage through reducing vascular_peroxidase-1 in a JNK signaling-dependent manner in endothelial cells .
9797192	0	vascular_type_1_angiotensin_II_receptor	14,53	angiotensin_II	98,112	vascular type 1 angiotensin II receptor	angiotensin II	24180(Tax:10116)	24179(Tax:10116)	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|dep|role role|nmod|END_ENTITY	Regulation of vascular_type_1_angiotensin_II_receptor in hypertension and sodium loading : role of angiotensin_II .
2538330	0	vasoactive-intestinal-peptide	70,99	VIP	101,104	vasoactive-intestinal-peptide	VIP	7432	7432	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	A human melanoma-derived cell line -LRB- IGR39 -RRB- with a very high number of vasoactive-intestinal-peptide -LRB- VIP -RRB- receptors .
2538331	0	vasoactive-intestinal-peptide	70,99	VIP	101,104	vasoactive-intestinal-peptide	VIP	7432	7432	Gene	Gene	receptors|amod|START_ENTITY receptors|appos|END_ENTITY	A human melanoma-derived cell line -LRB- IGR39 -RRB- with a very high number of vasoactive-intestinal-peptide -LRB- VIP -RRB- receptors .
16708801	0	vasoactive_intestinal_peptide	12,41	MMP-9	57,62	vasoactive intestinal peptide	MMP-9	117064(Tax:10116)	81687(Tax:10116)	Gene	Gene	START_ENTITY|nmod|expression expression|compound|END_ENTITY	-LSB- Effects of vasoactive_intestinal_peptide on LPS-induced MMP-9 expression by alveolar macrophages in rats -RSB- .
19698755	0	vasoactive_intestinal_peptide	23,52	VIP	54,57	vasoactive intestinal peptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Adenoviral transfer of vasoactive_intestinal_peptide -LRB- VIP -RRB- gene inhibits rat aortic and pulmonary artery smooth muscle cell proliferation .
6786785	0	vasoactive_intestinal_peptide	11,40	VIP	42,45	vasoactive intestinal peptide	VIP	7432	7432	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	-LSB- Effect of vasoactive_intestinal_peptide -LRB- VIP -RRB- on prolactin secretion in man -RSB- .
8063743	0	vasoactive_intestinal_peptide	37,66	VIP	68,71	vasoactive intestinal peptide	VIP	7432	7432	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Transgenic_mice overexpressing human vasoactive_intestinal_peptide -LRB- VIP -RRB- gene in pancreatic beta cells .
7988440	0	vasoactive_intestinal_peptide	13,42	insulin-like_growth_factor_I	86,114	vasoactive intestinal peptide	insulin-like growth factor I	117064(Tax:10116)	24482(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Induction of vasoactive_intestinal_peptide gene expression and prolactin secretion by insulin-like_growth_factor_I in rat pituitary cells : evidence for an autoparacrine regulatory system .
18534815	0	vasoactive_intestinal_peptide_receptor-1	37,77	CD4	115,118	vasoactive intestinal peptide receptor-1	CD4	22354(Tax:10090)	12504(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|cells cells|compound|END_ENTITY	TCR signaling and environment affect vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- expression in primary mouse CD4 T cells .
18555660	0	vasoactive_intestinal_peptide_receptor-1	58,98	CD4	125,128	vasoactive intestinal peptide receptor-1	CD4	22354(Tax:10090)	12504(Tax:10090)	Gene	Gene	VPAC-1|amod|START_ENTITY VPAC-1|nmod|cells cells|compound|END_ENTITY	Stimulatory and suppressive signal transduction regulates vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- in primary mouse CD4 T cells .
19729043	0	vasoactive_intestinal_peptide_receptor-1	59,99	CD4	159,162	vasoactive intestinal peptide receptor-1	CD4	22354(Tax:10090)	12504(Tax:10090)	Gene	Gene	promoter|amod|START_ENTITY landscape|nmod|promoter suggests|nsubj|landscape suggests|dobj|position position|nmod|cells cells|compound|END_ENTITY	A transcriptionally permissive epigenetic landscape at the vasoactive_intestinal_peptide_receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T cells .
18534815	0	vasoactive_intestinal_peptide_receptor-1	37,77	VPAC-1	79,85	vasoactive intestinal peptide receptor-1	VPAC-1	22354(Tax:10090)	22354(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	TCR signaling and environment affect vasoactive_intestinal_peptide_receptor-1 -LRB- VPAC-1 -RRB- expression in primary mouse CD4 T cells .
8784267	0	vasoactive_intestinal_peptide_receptor_1	29,69	VIP-R1	71,77	vasoactive intestinal peptide receptor 1	VIP-R1	22354(Tax:10090)	22354(Tax:10090)	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Murine T-lymphocytes express vasoactive_intestinal_peptide_receptor_1 -LRB- VIP-R1 -RRB- mRNA .
14574682	0	vasoactive_intestinal_polypeptide	58,91	Brain-derived_neurotrophic_factor	0,33	vasoactive intestinal polypeptide	Brain-derived neurotrophic factor	22353(Tax:10090)	12064(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor regulates expression of vasoactive_intestinal_polypeptide in retinal amacrine cells .
22895780	0	vasoactive_intestinal_polypeptide	32,65	Glucagon-like_peptide_2	0,23	vasoactive intestinal polypeptide	Glucagon-like peptide 2	7432	2641	Gene	Gene	expression|amod|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Glucagon-like_peptide_2 induces vasoactive_intestinal_polypeptide expression in enteric neurons via phophatidylinositol 3-kinase-y signaling .
7912096	0	vasoactive_intestinal_polypeptide	94,127	Pituitary_adenylate_cyclase-activating_polypeptide	0,50	vasoactive intestinal polypeptide	Pituitary adenylate cyclase-activating polypeptide	22353(Tax:10090)	11516(Tax:10090)	Gene	Gene	induces|nmod|START_ENTITY induces|nsubj|END_ENTITY	Pituitary_adenylate_cyclase-activating_polypeptide induces cAMP production independently from vasoactive_intestinal_polypeptide in osteoblast-like cells .
10545014	0	vasoactive_intestinal_polypeptide	14,47	VIP	49,52	vasoactive intestinal polypeptide	VIP	22353(Tax:10090)	22353(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition by vasoactive_intestinal_polypeptide -LRB- VIP -RRB- of angiogenesis induced by murine Colon 26-L5 carcinoma cells metastasized in liver .
10970071	0	vasoactive_intestinal_polypeptide	10,43	VIP	45,48	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- release and cell morphology in human pituitary_adenoma_cell_cultures .
11283411	0	vasoactive_intestinal_polypeptide	32,65	VIP	67,70	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution and synaptology of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- immunoreactive structures in the rat periaqueductal grey .
15745085	0	vasoactive_intestinal_polypeptide	19,52	VIP	54,57	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	START_ENTITY|dobj|levels levels|appos|END_ENTITY	Do elevated plasma vasoactive_intestinal_polypeptide -LRB- VIP -RRB- levels cause small intestinal motor disturbances in humans ?
1639036	0	vasoactive_intestinal_polypeptide	25,58	VIP	60,63	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Hypothyroidism increases vasoactive_intestinal_polypeptide -LRB- VIP -RRB- immunoreactivity and gene expression in the rat hypothalamic paraventricular nucleus .
1653848	0	vasoactive_intestinal_polypeptide	16,49	VIP	51,54	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- binding in circular muscle and characterization of VIP binding in canine small intestinal mucosa .
1687549	0	vasoactive_intestinal_polypeptide	14,47	VIP	49,52	vasoactive intestinal polypeptide	VIP	484038(Tax:9615)	484038(Tax:9615)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the canine_gallbladder motility .
2081700	0	vasoactive_intestinal_polypeptide	11,44	VIP	46,49	vasoactive intestinal polypeptide	VIP	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Changes in vasoactive_intestinal_polypeptide -LRB- VIP -RRB- levels in the rabbit oviduct at different hormonal stages .
215990	0	vasoactive_intestinal_polypeptide	20,53	VIP	55,58	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	release|nmod|START_ENTITY release|appos|END_ENTITY	Cyclical release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- from a pancreatic islet cell apudoma .
2323384	0	vasoactive_intestinal_polypeptide	14,47	VIP	49,52	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on forskolin stimulated adenylate cyclase in the caudate-putamen of the rat .
2380503	0	vasoactive_intestinal_polypeptide	80,113	VIP	115,118	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|appos|END_ENTITY	Changes in adrenal neuropeptides content -LSB- peptide 7B2 , neuropeptide_Y -LRB- NPY -RRB- and vasoactive_intestinal_polypeptide -LRB- VIP -RRB- -RSB- induced by pharmacological and hormonal manipulations .
24395090	0	vasoactive_intestinal_polypeptide	14,47	VIP	49,52	vasoactive intestinal polypeptide	VIP	22353(Tax:10090)	22353(Tax:10090)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|appos|END_ENTITY	Inhibition of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- induces resistance to dextran sodium_sulfate -LRB- DSS -RRB- - induced colitis in mice .
2546409	0	vasoactive_intestinal_polypeptide	15,48	VIP	50,53	vasoactive intestinal polypeptide	VIP	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	-LSB- The effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on ocular_inflammation in rabbit ocular tissue -RSB- .
2666962	0	vasoactive_intestinal_polypeptide	13,46	VIP	48,51	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Influence|nmod|START_ENTITY Influence|appos|END_ENTITY	Influence of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on splanchnic and central hemodynamics in healthy subjects .
3047320	0	vasoactive_intestinal_polypeptide	35,68	VIP	70,73	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunocytochemical localization of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in the brain of the little brown bat -LRB- Myotis lucifugus -RRB- .
3420301	0	vasoactive_intestinal_polypeptide	10,43	VIP	45,48	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on glucose and lipid metabolism of isolated rat adipocytes .
3562902	0	vasoactive_intestinal_polypeptide	10,43	VIP	45,48	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on steroidogenesis in women .
3891019	0	vasoactive_intestinal_polypeptide	33,66	VIP	68,71	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	effect|nmod|START_ENTITY effect|appos|END_ENTITY	Selective facilitatory effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on muscarinic firing in vesical ganglia of the cat .
3911302	0	vasoactive_intestinal_polypeptide	8,41	VIP	43,46	vasoactive intestinal polypeptide	VIP	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in the neurogenic vasodilatation of the portal vein in the rabbit .
510498	0	vasoactive_intestinal_polypeptide	11,44	VIP	46,49	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	study|nmod|START_ENTITY study|appos|END_ENTITY	A study of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- stimulated intestinal fluid secretion in rat and its inhibition by indomethacin .
594650	0	vasoactive_intestinal_polypeptide	11,44	VIP	46,49	vasoactive intestinal polypeptide	VIP	100500718	100500718	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- by intraduodenal stimuli .
6089138	0	vasoactive_intestinal_polypeptide	8,41	VIP	43,46	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in regulating the pituitary function in man .
6311891	0	vasoactive_intestinal_polypeptide	12,45	VIP	47,50	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	The role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- as a hypothalamic neurohormone .
6361235	0	vasoactive_intestinal_polypeptide	11,44	VIP	46,49	vasoactive intestinal polypeptide	VIP	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on renal function and plasma renin activity in the conscious rabbit .
6768592	0	vasoactive_intestinal_polypeptide	11,44	VIP	46,49	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in human prolactin -LRB- PRL -RRB- secreting pituitary_adenomas .
6889362	0	vasoactive_intestinal_polypeptide	24,57	VIP	59,62	vasoactive intestinal polypeptide	VIP	117064(Tax:10116)	117064(Tax:10116)	Gene	Gene	effects|nmod|START_ENTITY effects|appos|END_ENTITY	Vasodilatory effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on isolated rat arteries .
7084506	0	vasoactive_intestinal_polypeptide	10,43	VIP	45,48	vasoactive intestinal polypeptide	VIP	100352512(Tax:9986)	100352512(Tax:9986)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the in vitro and in vivo motility of the rabbit reproductive tract .
787988	0	vasoactive_intestinal_polypeptide	16,49	VIP	51,54	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Localization|nmod|START_ENTITY Localization|appos|END_ENTITY	Localization of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- to central and peripheral neurons .
8119061	0	vasoactive_intestinal_polypeptide	10,43	VIP	45,48	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on pulmonary ventilation-perfusion relationships and central haemodynamics in healthy subjects .
830595	0	vasoactive_intestinal_polypeptide	11,44	VIP	46,49	vasoactive intestinal polypeptide	VIP	100500718	100500718	Gene	Gene	Release|nmod|START_ENTITY Release|appos|END_ENTITY	Release of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- by electric stimulation of the vagal nerves .
8514821	0	vasoactive_intestinal_polypeptide	11,44	VIP	46,49	vasoactive intestinal polypeptide	VIP	280956(Tax:9913)	280956(Tax:9913)	Gene	Gene	Effects|nmod|START_ENTITY Effects|appos|END_ENTITY	Effects of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the neuromuscular complex in the bovine ovarian follicle wall .
8593294	0	vasoactive_intestinal_polypeptide	10,43	VIP	45,48	vasoactive intestinal polypeptide	VIP	100145884(Tax:9940)	100145884(Tax:9940)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on the net movement of electrolytes and water and glucose absorption in the jejunal loop of sheep .
8790778	0	vasoactive_intestinal_polypeptide	20,53	VIP	55,58	vasoactive intestinal polypeptide	VIP	7432	7432	Gene	Gene	significance|nmod|START_ENTITY significance|appos|END_ENTITY	The significance of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in immunomodulation .
10970071	0	vasoactive_intestinal_polypeptide	10,43	growth_hormone	53,67	vasoactive intestinal polypeptide	growth hormone	7432	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- on growth_hormone -LRB- GH -RRB- and prolactin -LRB- PRL -RRB- release and cell morphology in human pituitary_adenoma_cell_cultures .
6120948	0	vasoactive_intestinal_polypeptide	10,43	growth_hormone	47,61	vasoactive intestinal polypeptide	growth hormone	7432	2688	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|secretion secretion|amod|END_ENTITY	Effect of vasoactive_intestinal_polypeptide on growth_hormone secretion in perifused acromegalic pituitary adenoma tissues .
17065411	0	vasoactive_intestinal_polypeptide	96,129	pituitary_adenylate_cyclase-activating_polypeptide	45,95	vasoactive intestinal polypeptide	pituitary adenylate cyclase-activating polypeptide	117064(Tax:10116)	24166(Tax:10116)	Gene	Gene	receptors|amod|START_ENTITY Characterization|dep|receptors Characterization|nmod|END_ENTITY	Characterization and expression of different pituitary_adenylate_cyclase-activating_polypeptide / vasoactive_intestinal_polypeptide receptors in rat ovarian follicles .
7609919	0	vasoactive_intestinal_polypeptide	24,57	pituitary_adenylate_cyclase-activating_polypeptide	95,145	vasoactive intestinal polypeptide	pituitary adenylate cyclase-activating polypeptide	117064(Tax:10116)	24166(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY stimulating|nsubj|involvement stimulating|dobj|action action|nmod|END_ENTITY	Possible involvement of vasoactive_intestinal_polypeptide in the central stimulating action of pituitary_adenylate_cyclase-activating_polypeptide on prolactin secretion in the rat .
3493951	0	vasoactive_intestinal_polypeptide	19,52	prolactin	89,98	vasoactive intestinal polypeptide	prolactin	7432	5617	Gene	Gene	effect|nmod|START_ENTITY histidine_isoleucine|nsubj|effect histidine_isoleucine|nmod|secretion secretion|compound|END_ENTITY	In vitro effect of vasoactive_intestinal_polypeptide and peptide histidine_isoleucine on prolactin secretion by the bullfrog pituitary gland .
3841194	0	vasoactive_intestinal_polypeptide	30,63	prolactin	122,131	vasoactive intestinal polypeptide	prolactin	117064(Tax:10116)	24683(Tax:10116)	Gene	Gene	antisera|acl|START_ENTITY Administration|nmod|antisera attenuates|nsubj|Administration attenuates|dobj|secretion secretion|compound|END_ENTITY	Administration of antisera to vasoactive_intestinal_polypeptide and peptide histidine_isoleucine attenuates ether-induced prolactin secretion in rats .
3872804	0	vasoactive_intestinal_polypeptide	27,60	prolactin	70,79	vasoactive intestinal polypeptide	prolactin	117064(Tax:10116)	24683(Tax:10116)	Gene	Gene	antiserum|acl|START_ENTITY antiserum|nmod|secretion secretion|compound|END_ENTITY	Inhibition by antiserum to vasoactive_intestinal_polypeptide -LRB- VIP -RRB- of prolactin secretion induced by serotonin in the rat .
4090907	0	vasoactive_intestinal_polypeptide	60,93	prolactin	15,24	vasoactive intestinal polypeptide	prolactin	7432	5617	Gene	Gene	injected|dobj|START_ENTITY injected|nsubj|Lack Lack|nmod|response response|compound|END_ENTITY	Lack of plasma prolactin response to intravenously injected vasoactive_intestinal_polypeptide in patients with prolactin-secreting adenoma .
6709640	0	vasoactive_intestinal_polypeptide	28,61	prolactin	71,80	vasoactive intestinal polypeptide	prolactin	117064(Tax:10116)	24683(Tax:10116)	Gene	Gene	START_ENTITY|nmod|secretion secretion|compound|END_ENTITY	Involvement of hypothalamic vasoactive_intestinal_polypeptide -LRB- VIP -RRB- in prolactin secretion induced by serotonin in rats .
7266772	0	vasoactive_intestinal_polypeptide	56,89	prolactin	15,24	vasoactive intestinal polypeptide	prolactin	117064(Tax:10116)	707052(Tax:9544)	Gene	Gene	secretion|nmod|START_ENTITY secretion|nsubj|Stimulation Stimulation|nmod|END_ENTITY	Stimulation of prolactin secretion in rhesus_monkeys by vasoactive_intestinal_polypeptide .
7609919	0	vasoactive_intestinal_polypeptide	24,57	prolactin	149,158	vasoactive intestinal polypeptide	prolactin	117064(Tax:10116)	24683(Tax:10116)	Gene	Gene	involvement|nmod|START_ENTITY stimulating|nsubj|involvement stimulating|nmod|secretion secretion|compound|END_ENTITY	Possible involvement of vasoactive_intestinal_polypeptide in the central stimulating action of pituitary_adenylate_cyclase-activating_polypeptide on prolactin secretion in the rat .
8361528	0	vasoactive_intestinal_polypeptide	8,41	secretin	49,57	vasoactive intestinal polypeptide	secretin	484038(Tax:9615)	483407(Tax:9615)	Gene	Gene	Role|nmod|START_ENTITY Role|appos|END_ENTITY	Role of vasoactive_intestinal_polypeptide -LRB- VIP -RRB- , secretin and gastrin in the genesis of the late exocrine pancreatic_hypersecretion , _ food_intake dependent in conscious dogs .
8930157	0	vasoactive_intestinal_polypeptide	68,101	secretin_receptor	113,130	vasoactive intestinal polypeptide	secretin receptor	117064(Tax:10116)	81779(Tax:10116)	Gene	Gene	basis|nmod|START_ENTITY basis|nmod|END_ENTITY	Molecular basis and species specificity of high affinity binding of vasoactive_intestinal_polypeptide by the rat secretin_receptor .
12087107	0	vasodilator-stimulated_phosphoprotein	14,51	Abl	89,92	vasodilator-stimulated phosphoprotein	Abl	7408	25	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|nmod|END_ENTITY	Regulation of vasodilator-stimulated_phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion .
18813837	0	vasodilator-stimulated_phosphoprotein	49,86	Rac1	91,95	vasodilator-stimulated phosphoprotein	Rac1	7408	5879	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|pathway pathway|amod|END_ENTITY	Positive regulation of migration and invasion by vasodilator-stimulated_phosphoprotein via Rac1 pathway in human breast_cancer cells .
14602552	0	vasodilator-stimulated_phosphoprotein	23,60	VASP	62,66	vasodilator-stimulated phosphoprotein	VASP	7408	7408	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of the vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- by the anti-platelet drug , cilostazol , in platelets .
16480498	0	vasodilator-stimulated_phosphoprotein	15,52	VASP	54,58	vasodilator-stimulated phosphoprotein	VASP	7408	7408	Gene	Gene	phosphorylation|amod|START_ENTITY phosphorylation|appos|END_ENTITY	Alterations in vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- phosphorylation : associations with asthmatic phenotype , airway inflammation and beta2-agonist use .
21163344	0	vasodilator-stimulated_phosphoprotein	35,72	VASP	74,78	vasodilator-stimulated phosphoprotein	VASP	7408	7408	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Spatial and temporal expression of vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- in fetal and adult human cerebral cortex .
22216296	0	vasodilator-stimulated_phosphoprotein	19,56	VASP	58,62	vasodilator-stimulated phosphoprotein	VASP	22323(Tax:10090)	22323(Tax:10090)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|appos|END_ENTITY	Phosphorylation of vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- dampens hepatic_ischemia-reperfusion injury .
25543053	0	vasodilator-stimulated_phosphoprotein	26,63	VASP	65,69	vasodilator-stimulated phosphoprotein	VASP	7408	7408	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|appos|END_ENTITY	Serine phosphorylation of vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- regulates colon_cancer cell survival and apoptosis .
8812448	0	vasodilator-stimulated_phosphoprotein	21,58	VASP	15,19	vasodilator-stimulated phosphoprotein	VASP	7408	7408	Gene	Gene	genes|appos|START_ENTITY genes|compound|END_ENTITY	Cloning of the VASP -LRB- vasodilator-stimulated_phosphoprotein -RRB- genes in human and mouse : structure , sequence , and chromosomal localization .
11598195	0	vasodilator-stimulated_phosphoprotein	30,67	Zyxin	0,5	vasodilator-stimulated phosphoprotein	Zyxin	7408	7791	Gene	Gene	colocalized|nmod|START_ENTITY colocalized|nsubjpass|END_ENTITY	Zyxin is not colocalized with vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- at lamellipodial tips and exhibits different dynamics to vinculin , paxillin , and VASP in focal adhesions .
24857403	0	vasodilator-stimulated_phosphoprotein	96,133	interleukin-1_receptor-associated_kinase_1	31,73	vasodilator-stimulated phosphoprotein	interleukin-1 receptor-associated kinase 1	7408	3654	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Isomerase-catalyzed binding of interleukin-1_receptor-associated_kinase_1 to the EVH1 domain of vasodilator-stimulated_phosphoprotein .
2132633	0	vasopressin	51,62	AVP	64,67	vasopressin	AVP	551	551	Gene	Gene	levels|compound|START_ENTITY levels|appos|END_ENTITY	Water immersion -LRB- WI -RRB- induced alterations of plasma vasopressin -LRB- AVP -RRB- levels in patients with noninflammatory acute_renal_failure -LRB- NARF -RRB- and in patients with chronic_renal_failure -LRB- CRF -RRB- .
2138551	0	vasopressin	6,17	AVP	19,22	vasopressin	AVP	551	551	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Serum vasopressin -LRB- AVP -RRB- levels in polyuric brain-dead organ donors .
1649836	0	vasopressin	46,57	Adrenocorticotropin	0,19	vasopressin	Adrenocorticotropin	551	5443	Gene	Gene	START_ENTITY|nsubj|responses responses|compound|END_ENTITY	Adrenocorticotropin and cortisol responses to vasopressin during pregnancy .
10718520	0	vasopressin	74,85	Fos	43,46	vasopressin	Fos	551	2353	Gene	Gene	induces|nmod|START_ENTITY induces|dobj|expression expression|compound|END_ENTITY	Intraventricular 2-deoxy-D-glucose induces Fos expression by hypothalamic vasopressin , but not oxytocin neurons .
8159270	0	vasopressin	59,70	IL-1_beta	0,9	vasopressin	IL-1 beta	551	3553	Gene	Gene	release|nmod|START_ENTITY potentiates|dobj|release potentiates|nsubj|END_ENTITY	IL-1_beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro , but not from the amygdala .
6255473	0	vasopressin	55,66	Insulin	0,7	vasopressin	Insulin	396995(Tax:9823)	397415(Tax:9823)	Gene	Gene	receptors|nmod|START_ENTITY number|nmod|receptors increase|dobj|number increase|nsubj|END_ENTITY	Insulin and serum increase the number of receptors for vasopressin in a kidney-derived line of cells grown in a defined medium .
12403649	0	vasopressin	42,53	Upstream_stimulatory_factor	0,27	vasopressin	Upstream stimulatory factor	551	7391	Gene	Gene	promoter|compound|START_ENTITY activates|dobj|promoter activates|nsubj|END_ENTITY	Upstream_stimulatory_factor activates the vasopressin promoter via multiple motifs , including a non-canonical E-box .
15469988	0	vasopressin	18,29	V2_receptor	30,41	vasopressin	V2 receptor	551	554	Gene	Gene	Regulation|nmod|START_ENTITY END_ENTITY|nsubj|Regulation	Regulation of the vasopressin V2_receptor by vasopressin in polarized renal collecting duct cells .
427046	0	vasopressin	43,54	VIII	26,30	vasopressin	VIII	551	1351	Gene	Gene	infusion|compound|START_ENTITY END_ENTITY|nmod|infusion	Specificity in the factor VIII response to vasopressin infusion in man .
21299514	0	vasopressin	36,47	Vasopressin	0,11	vasopressin	Vasopressin	551	551	Gene	Gene	combination|nmod|START_ENTITY END_ENTITY|nmod|combination	Vasopressin versus a combination of vasopressin and tourniquets : a comparison of blood_loss in patients undergoing abdominal myomectomies .
12669273	0	vasopressin	64,75	aquaporin-2	21,32	vasopressin	aquaporin-2	551	359	Gene	Gene	secretion|nmod|START_ENTITY secretion|amod|END_ENTITY	Urinary excretion of aquaporin-2 and inappropriate secretion of vasopressin in hyponatremic patients after cerebral_infarction .
6319453	0	vasopressin	69,80	corticotropin-releasing_factor	20,50	vasopressin	corticotropin-releasing factor	551	1392	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	The effect of ovine corticotropin-releasing_factor on catecholamine , vasopressin , and aldosterone secretion in normal man .
7835313	0	vasopressin	78,89	glucocorticoid_receptor	13,36	vasopressin	glucocorticoid receptor	551	2908	Gene	Gene	expression|nmod|START_ENTITY expression|compound|END_ENTITY	Induction of glucocorticoid_receptor expression in hypothalamic magnocellular vasopressin neurons during chronic hypoosmolality .
3551628	0	vasopressin	39,50	insulin	10,17	vasopressin	insulin	551	3630	Gene	Gene	Effect|nmod|START_ENTITY Effect|nmod|END_ENTITY	Effect of insulin on osmoregulation of vasopressin .
2872161	0	vasopressin	17,28	renin	36,41	vasopressin	renin	551	5972	Gene	Gene	START_ENTITY|nmod|hypertension hypertension|amod|END_ENTITY	Increased plasma vasopressin in low renin essential hypertension .
3513487	0	vasopressin	49,60	renin	82,87	vasopressin	renin	551	5972	Gene	Gene	activity|compound|START_ENTITY activity|compound|END_ENTITY	Cardiovascular haemodynamics and the response of vasopressin , aldosterone , plasma renin activity and plasma catecholamines to head-up tilt in young and old healthy subjects .
6367368	0	vasopressin	17,28	renin	60,65	vasopressin	renin	551	5972	Gene	Gene	uric_acid|nsubj|START_ENTITY uric_acid|nmod|type type|compound|END_ENTITY	Increased plasma vasopressin and serum uric_acid in the low renin type of essential hypertension .
1803271	0	vasopressin	26,37	snail	109,114	vasopressin	snail	551	6615	Gene	Gene	Influence|nmod|START_ENTITY Influence|nmod|END_ENTITY	Influence of an analog of vasopressin on the reaction of command neurons of defensive behavior of the edible snail during the stimulation of nerves .
2174617	0	vasopressin	17,28	snail	115,120	vasopressin	snail	551	6615	Gene	Gene	analog|compound|START_ENTITY effect|nmod|analog -LSB-|dobj|effect neurons|csubj|-LSB- neurons|nmod|behavior behavior|nmod|END_ENTITY	-LSB- The effect of a vasopressin analog on the reaction of the command neurons in the defensive behavior of the edible snail during nerve stimulation -RSB- .
6108897	0	vasopressin	118,129	somatostatin	11,23	vasopressin	somatostatin	551	6750	Gene	Gene	comparison|nmod|START_ENTITY Effects|dep|comparison Effects|nmod|END_ENTITY	Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis_of_the_liver : comparison with vasopressin .
11038011	0	vasopressin	76,87	vasopressin	96,107	vasopressin	vasopressin	551	551	Gene	Gene	gene|compound|START_ENTITY gene|nmod|expression expression|compound|END_ENTITY	Effects of various mutations in the neurophysin/glycopeptide portion of the vasopressin gene on vasopressin expression in vitro .
11038011	0	vasopressin	96,107	vasopressin	76,87	vasopressin	vasopressin	551	551	Gene	Gene	expression|compound|START_ENTITY gene|nmod|expression gene|compound|END_ENTITY	Effects of various mutations in the neurophysin/glycopeptide portion of the vasopressin gene on vasopressin expression in vitro .
8151095	0	vasopressin	11,22	vasopressin	118,129	vasopressin	vasopressin	551	551	Gene	Gene	Effects|nmod|START_ENTITY Effects|dep|comparison comparison|nmod|END_ENTITY	Effects of vasopressin and nicardipine on hemodynamics and liver function in patients with cirrhosis : comparison with vasopressin alone .
8151095	0	vasopressin	118,129	vasopressin	11,22	vasopressin	vasopressin	551	551	Gene	Gene	comparison|nmod|START_ENTITY Effects|dep|comparison Effects|nmod|END_ENTITY	Effects of vasopressin and nicardipine on hemodynamics and liver function in patients with cirrhosis : comparison with vasopressin alone .
21170088	0	vasorin	63,70	TGFb	24,28	vasorin	TGFb	114990	7040	Gene	Gene	cleavage|nmod|START_ENTITY signaling|nmod|cleavage END_ENTITY|acl|signaling	ADAM17 -LRB- TACE -RRB- regulates TGFb signaling through the cleavage of vasorin .
22426063	0	vasorin	14,21	Vasn	23,27	vasorin	Vasn	246154(Tax:10090)	246154(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of vasorin -LRB- Vasn -RRB- during embryonic development of the mouse .
17458235	0	vaspin	7,13	ACAM	1,5	vaspin	ACAM	145264	79827	Gene	Gene	-RSB-|compound|START_ENTITY END_ENTITY|appos|-RSB-	-LSB- ACAM , vaspin -RSB- .
1565462	0	vav	32,35	dbl	76,79	vav	dbl	7409	4168	Gene	Gene	shares|amod|START_ENTITY expressed|dobj|shares expressed|nmod|factor factor|compound|END_ENTITY	The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor , the bcr gene and a yeast gene -LRB- CDC24 -RRB- involved in cytoskeletal organization .
8710375	0	vav	63,66	vav2	41,45	vav	vav2	22324(Tax:10090)	22325(Tax:10090)	Gene	Gene	family|compound|START_ENTITY member|nmod|family END_ENTITY|appos|member	Isolation and characterization of murine vav2 , a member of the vav family of proto-oncogenes .
8710375	0	vav2	41,45	vav	63,66	vav2	vav	22325(Tax:10090)	22324(Tax:10090)	Gene	Gene	START_ENTITY|appos|member member|nmod|family family|compound|END_ENTITY	Isolation and characterization of murine vav2 , a member of the vav family of proto-oncogenes .
22170591	0	vegf	41,45	mTORC1	58,64	vegf	mTORC1	7422	382056(Tax:10090)	Gene	Gene	pathway|compound|START_ENTITY pathway|nmod|END_ENTITY	Electroconvulsive seizures stimulate the vegf pathway via mTORC1 .
10656251	0	ventral_midline_antigen	40,63	VEMA	26,30	ventral midline antigen	VEMA	291948(Tax:10116)	291948(Tax:10116)	Gene	Gene	Cloning|dep|START_ENTITY Cloning|nmod|END_ENTITY	Cloning and expression of VEMA : a novel ventral_midline_antigen in the rat CNS .
19441085	0	ventricular_myosin_heavy_chain	61,91	vmhc	93,97	ventricular myosin heavy chain	vmhc	30616(Tax:7955)	30616(Tax:7955)	Gene	Gene	gene|compound|START_ENTITY gene|dep|END_ENTITY	Isolation of a ventricle-specific promoter for the zebrafish ventricular_myosin_heavy_chain -LRB- vmhc -RRB- gene and its regulation by GATA factors during embryonic heart development .
19517572	0	ventricular_myosin_heavy_chain	21,51	vmhc	53,57	ventricular myosin heavy chain	vmhc	30616(Tax:7955)	30616(Tax:7955)	Gene	Gene	analysis|nmod|START_ENTITY analysis|dep|END_ENTITY	Promoter analysis of ventricular_myosin_heavy_chain -LRB- vmhc -RRB- in zebrafish embryos .
12907688	0	versican	68,76	ADAMTS-1	31,39	versican	ADAMTS-1	13003(Tax:10090)	11504(Tax:10090)	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|amod|END_ENTITY	Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation .
24147033	0	versican	14,22	BMP-2	0,5	versican	BMP-2	395565(Tax:9031)	378779(Tax:9031)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration .
19861583	0	very-low-density_lipoprotein_receptor	90,127	Peroxisome_proliferator-activated_receptor-gamma	0,48	very-low-density lipoprotein receptor	Peroxisome proliferator-activated receptor-gamma	22359(Tax:10090)	19016(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Peroxisome_proliferator-activated_receptor-gamma regulates the expression and function of very-low-density_lipoprotein_receptor .
11278667	0	very_low_density_lipoprotein_receptor	97,134	Tissue_factor_pathway_inhibitor	0,31	very low density lipoprotein receptor	Tissue factor pathway inhibitor	7436	7035	Gene	Gene	inhibits|nmod|START_ENTITY inhibits|nsubj|END_ENTITY	Tissue_factor_pathway_inhibitor inhibits endothelial cell proliferation via association with the very_low_density_lipoprotein_receptor .
11501949	0	very_low_density_lipoprotein_receptor	39,76	VLDLR	78,83	very low density lipoprotein receptor	VLDLR	7436	7436	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Single nucleotide polymorphisms of the very_low_density_lipoprotein_receptor -LRB- VLDLR -RRB- gene .
15147890	0	very_low_density_lipoprotein_receptor	33,70	farnesoid_X_receptor	4,24	very low density lipoprotein receptor	farnesoid X receptor	22359(Tax:10090)	20186(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	The farnesoid_X_receptor induces very_low_density_lipoprotein_receptor gene expression .
18665321	0	vesicle-associated_membrane_protein-associated_protein_A	41,97	VAPA	99,103	vesicle-associated membrane protein-associated protein A	VAPA	9218	9218	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between polymorphisms in the vesicle-associated_membrane_protein-associated_protein_A -LRB- VAPA -RRB- gene on chromosome 18p and bipolar_disorder .
19526558	0	vesicle-inducing_protein_in_plastids_1	131,169	HSP90C	207,213	vesicle-inducing protein in plastids 1	HSP90C	5719360(Tax:3055)	5728553(Tax:3055)	Gene	Gene	START_ENTITY|nmod|complex complex|nmod|END_ENTITY	Application of quantitative immunoprecipitation combined with knockdown and cross-linking to Chlamydomonas reveals the presence of vesicle-inducing_protein_in_plastids_1 in a common complex with chloroplast HSP90C .
2036362	0	vesicle_aggregation	28,47	Cytochrome_P-450scc	0,19	cytochrome P-450scc	Cytochrome P-450scc	338048(Tax:9913)	338048(Tax:9913)	Gene	Gene	induces|dobj|START_ENTITY induces|nsubj|END_ENTITY	Cytochrome_P-450scc induces vesicle_aggregation through a secondary interaction at the adrenodoxin binding sites -LRB- in competition with protein exchange .
20005125	0	vesicle_associated_membrane_protein2	38,74	VAMP2	76,81	vesicle associated membrane protein2	VAMP2	22318(Tax:10090)	22318(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and expression of a region of vesicle_associated_membrane_protein2 -LRB- VAMP2 -RRB- gene and its use as a recombinant peptide substrate for assaying clostridial_neurotoxins in contaminated biologicals .
15103023	0	vesicular_glutamate_transporter_1	22,55	VGLUT1	57,63	vesicular glutamate transporter 1	VGLUT1	72961(Tax:10090)	72961(Tax:10090)	Gene	Gene	role|nmod|START_ENTITY role|appos|END_ENTITY	An essential role for vesicular_glutamate_transporter_1 -LRB- VGLUT1 -RRB- in postnatal development and control of quantal size .
18155072	0	vesicular_glutamate_transporter_2	24,57	VGLUT2	59,65	vesicular glutamate transporter 2	VGLUT2	57084	57084	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Antipsychotics increase vesicular_glutamate_transporter_2 -LRB- VGLUT2 -RRB- expression in thalamolimbic pathways .
22684983	0	vesicular_glutamate_transporter_2	16,49	VGluT2	51,57	vesicular glutamate transporter 2	VGluT2	57084	57084	Gene	Gene	Distribution|nmod|START_ENTITY Distribution|appos|END_ENTITY	Distribution of vesicular_glutamate_transporter_2 -LRB- VGluT2 -RRB- in the primary visual cortex of the macaque and human .
21618220	0	vesicular_glutamate_transporter_2	36,69	vGluT2	71,77	vesicular glutamate transporter 2	vGluT2	102093241	102093241	Gene	Gene	localization|nmod|START_ENTITY localization|appos|END_ENTITY	Immunohistochemical localization of vesicular_glutamate_transporter_2 -LRB- vGluT2 -RRB- in the central nervous system of the pigeon -LRB- Columba_livia -RRB- .
26876757	0	vesicular_glutamate_transporter_3	43,76	Brain-derived_neurotrophic_factor	0,33	vesicular glutamate transporter 3	Brain-derived neurotrophic factor	246213	627	Gene	Gene	expression|amod|START_ENTITY promotes|dobj|expression promotes|nsubj|END_ENTITY	Brain-derived_neurotrophic_factor promotes vesicular_glutamate_transporter_3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5 .
24316448	0	vesicular_glutamate_transporter_3	18,51	brain-derived_neurotrophic_factor	101,134	vesicular glutamate transporter 3	brain-derived neurotrophic factor	266767(Tax:10116)	24225(Tax:10116)	Gene	Gene	expression|nmod|START_ENTITY induced|nsubj|expression induced|nmod|END_ENTITY	The expression of vesicular_glutamate_transporter_3 and vesicular_monoamine_transporter_2 induced by brain-derived_neurotrophic_factor in dorsal root ganglion neurons in vitro .
19457116	0	vesicular_monoamine_transporter-2	49,82	Hsc70	24,29	vesicular monoamine transporter-2	Hsc70	6571	3312	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	The molecular chaperone Hsc70 interacts with the vesicular_monoamine_transporter-2 .
17134514	0	vesicular_monoamine_transporter_1	25,58	VMAT1	60,65	vesicular monoamine transporter 1	VMAT1	6570	6570	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association study of the vesicular_monoamine_transporter_1 -LRB- VMAT1 -RRB- gene with schizophrenia in a Japanese population .
18041582	0	vesicular_monoamine_transporter_2	79,112	VMAT2	114,119	vesicular monoamine transporter 2	VMAT2	214084(Tax:10090)	214084(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A metabolomic study of brain tissues from aged mice with low expression of the vesicular_monoamine_transporter_2 -LRB- VMAT2 -RRB- gene .
23404442	0	vesicular_monoamine_transporter_2	17,50	VMAT2	52,57	vesicular monoamine transporter 2	VMAT2	6571	6571	Gene	Gene	expression|compound|START_ENTITY expression|appos|END_ENTITY	Species-specific vesicular_monoamine_transporter_2 -LRB- VMAT2 -RRB- expression in mammalian pancreatic beta cells : implications for optimising radioligand-based human beta_cell_mass -LRB- BCM -RRB- imaging in animal models .
17442673	0	vesicular_monoamine_transporter_type_2	52,90	gastrin	20,27	vesicular monoamine transporter type 2	gastrin	25549(Tax:10116)	25320(Tax:10116)	Gene	Gene	promoter|amod|START_ENTITY Identification|nmod|promoter Identification|nmod|element element|compound|END_ENTITY	Identification of a gastrin response element in the vesicular_monoamine_transporter_type_2 promoter and requirement of 20 S proteasome subunits for transcriptional activity .
11054560	0	vg3	31,34	vitellogenin	12,24	vg3	vitellogenin	30518(Tax:7955)	101882735	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	A zebrafish vitellogenin gene -LRB- vg3 -RRB- encodes a novel vitellogenin without a phosvitin domain and may represent a primitive vertebrate vitellogenin gene .
7751058	0	vgr	22,25	BMP-6	27,32	vgr	BMP-6	25644(Tax:10116)	25644(Tax:10116)	Gene	Gene	Immunolocalization|nmod|START_ENTITY Immunolocalization|appos|END_ENTITY	Immunolocalization of vgr -LRB- BMP-6 , DVR-6 -RRB- , a TGF-beta related cytokine , to Schwann cells of the rat peripheral nervous system : expression patterns are not modulated by autoimmune_disease .
6403080	0	viii	40,44	Thrombin	0,8	viii	Thrombin	1351	2147	Gene	Gene	protein|compound|START_ENTITY proteolysis|nmod|protein proteolysis|compound|END_ENTITY	Thrombin proteolysis of purified factor viii procoagulant protein : correlation of activation with generation of a specific polypeptide .
3143730	0	vimentin	26,34	Angiotensin_II	0,14	vimentin	Angiotensin II	81818(Tax:10116)	24179(Tax:10116)	Gene	Gene	phosphorylation|compound|START_ENTITY stimulates|dobj|phosphorylation stimulates|nsubj|END_ENTITY	Angiotensin_II stimulates vimentin phosphorylation via a Ca2 + - dependent , protein kinase C-independent mechanism in cultured vascular smooth muscle cells .
12458200	0	vimentin	48,56	Aurora-B	0,8	vimentin	Aurora-B	7431	9212	Gene	Gene	phosphorylation|compound|START_ENTITY regulates|dobj|phosphorylation regulates|nsubj|END_ENTITY	Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process .
25736925	0	vimentin	54,62	C6orf106	0,8	vimentin	C6orf106	7431	64771	Gene	Gene	enhances|nmod|START_ENTITY enhances|nsubj|END_ENTITY	C6orf106 enhances NSCLC cell invasion by upregulating vimentin , and downregulating E-cadherin and P120ctn .
22216242	0	vimentin	58,66	CD44	8,12	vimentin	CD44	7431	960	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Soluble CD44 interacts with intermediate filament protein vimentin on endothelial cell surface .
17251187	0	vimentin	15,23	ERK	86,89	vimentin	ERK	7431	5594	Gene	Gene	assembly|compound|START_ENTITY assembly|nmod|activation activation|nmod|MAP MAP|compound|END_ENTITY	Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis .
18098284	0	vimentin	16,24	Fra-1	0,5	vimentin	Fra-1	7431	8061	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon_carcinoma cells .
20814740	0	vimentin	34,42	GFAP	28,32	vimentin	GFAP	7431	2670	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dobj|expression	Alpha-lipoic_acid modulates GFAP , vimentin , nestin , cyclin_D1 and MAP-kinase expression in astroglial cell cultures .
3134930	0	vimentin	69,77	GFAP	79,83	vimentin	GFAP	81818(Tax:10116)	24387(Tax:10116)	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	-LSB- Immunohistochemical study of developing rat embryo -- localization of vimentin , GFAP , neurofilament protein within rat embryo central nervous system -RSB- .
22236966	0	vimentin	20,28	HIPK2	0,5	vimentin	HIPK2	7431	28996	Gene	Gene	downregulates|dobj|START_ENTITY downregulates|nsubj|END_ENTITY	HIPK2 downregulates vimentin and inhibits breast_cancer cell invasion .
26824421	0	vimentin	102,110	Osteopontin	0,11	vimentin	Osteopontin	7431	6696	Gene	Gene	regulating|dobj|START_ENTITY promotes|advcl|regulating promotes|nsubj|END_ENTITY	Osteopontin promotes epithelial-mesenchymal transition of hepatocellular_carcinoma through regulating vimentin .
2822968	0	vimentin	48,56	P55	4,7	vimentin	P55	7431	347376	Gene	Gene	START_ENTITY|nsubj|protein protein|compound|END_ENTITY	The P55 protein affected by v-mos expression is vimentin .
9175763	0	vimentin	35,43	PKN	83,86	vimentin	PKN	7431	5585	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|nmod|END_ENTITY	Domain-specific phosphorylation of vimentin and glial_fibrillary_acidic_protein by PKN .
24447545	0	vimentin	16,24	RUNX3	0,5	vimentin	RUNX3	7431	864	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric_cancer cells .
16568083	0	vimentin	14,22	SIP1	26,30	vimentin	SIP1	7431	9839	Gene	Gene	Regulation|nmod|START_ENTITY Regulation|nmod|END_ENTITY	Regulation of vimentin by SIP1 in human epithelial breast_tumor cells .
14712222	0	vimentin	15,23	Stat3	0,5	vimentin	Stat3	7431	6774	Gene	Gene	expression|amod|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein , ZBP-89 .
23182613	0	vimentin	49,57	Transforming_growth_factor-b	0,28	vimentin	Transforming growth factor-b	7431	7040	Gene	Gene	expression|compound|START_ENTITY induces|dobj|expression induces|nsubj|END_ENTITY	Transforming_growth_factor-b transiently induces vimentin expression and invasive capacity in a canine mammary gland tumor cell line .
12771217	0	vimentin	17,25	ZBP-89	0,6	vimentin	ZBP-89	7431	7707	Gene	Gene	transcription|amod|START_ENTITY represses|dobj|transcription represses|nsubj|END_ENTITY	ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator , Sp1 .
15777792	0	vimentin	34,42	alpha2/beta1	155,167	vimentin	alpha2/beta1	7431	3779	Gene	Gene	binds|nsubj|START_ENTITY binds|nmod|END_ENTITY	The intermediate filament protein vimentin binds specifically to a recombinant integrin alpha2/beta1 cytoplasmic tail complex and co-localizes with native alpha2/beta1 in endothelial cell focal adhesions .
25716692	0	vimentin	120,128	bromodomain_PHD-finger_transcription_factor	31,74	vimentin	bromodomain PHD-finger transcription factor	7431	2186	Gene	Gene	significance|nmod|START_ENTITY significance|nmod|END_ENTITY	The prognostic significance of bromodomain_PHD-finger_transcription_factor in colorectal_carcinoma and association with vimentin and E-cadherin .
14654785	0	vimentin	54,62	c-Jun	0,5	vimentin	c-Jun	7431	3725	Gene	Gene	expression|amod|START_ENTITY induce|dobj|expression induce|nsubj|END_ENTITY	c-Jun and the dominant-negative mutant , TAM67 , induce vimentin gene expression by interacting with the activator Sp1 .
7983050	0	vimentin	30,38	cdc2	58,62	vimentin	cdc2	7431	983	Gene	Gene	Visualization|nmod|START_ENTITY phosphorylation|nsubj|Visualization phosphorylation|nmod|kinase kinase|amod|END_ENTITY	Visualization and function of vimentin phosphorylation by cdc2 kinase during mitosis .
8373419	0	vimentin	29,37	cdc2	50,54	vimentin	cdc2	7431	983	Gene	Gene	Phosphorylation|nmod|START_ENTITY peptides|nsubj|Phosphorylation peptides|nmod|kinase kinase|amod|END_ENTITY	Phosphorylation of synthetic vimentin peptides by cdc2 kinase .
3042384	0	vimentin	32,40	desmin	42,48	vimentin	desmin	22352(Tax:10090)	13346(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|dep|gene gene|amod|END_ENTITY	Tissue-specific expression of a vimentin -- desmin hybrid gene in transgenic_mice .
8085393	0	vimentin	36,44	desmin	46,52	vimentin	desmin	7431	1674	Gene	Gene	protein|compound|START_ENTITY protein|dep|END_ENTITY	Immunohistochemical distribution of vimentin , desmin , glial fibrillary acidic protein and neurofilament proteins in feline tissues .
2140597	0	vimentin	6,14	fos	43,46	vimentin	fos	22352(Tax:10090)	14281(Tax:10090)	Gene	Gene	START_ENTITY|dep|relationship relationship|nmod|END_ENTITY	Mouse vimentin : structural relationship to fos , jun , CREB and tpr .
19223297	0	vimentin	83,91	intermediate_filament	16,37	vimentin	intermediate filament	81818(Tax:10116)	24387(Tax:10116)	Gene	Gene	expressed|nsubjpass|START_ENTITY appraisal|dep|expressed appraisal|nmod|expression expression|amod|END_ENTITY	An appraisal of intermediate_filament expression in adult and developing pancreas : vimentin is expressed in alpha cells of rat and mouse embryos .
21426942	0	vimentin	87,95	intermediate_filament	96,117	vimentin	intermediate filament	81818(Tax:10116)	24387(Tax:10116)	Gene	Gene	system|compound|START_ENTITY system|compound|END_ENTITY	The nanomechanical properties of rat fibroblasts are modulated by interfering with the vimentin intermediate_filament system .
2661562	0	vimentin	14,22	intermediate_filament	34,55	vimentin	intermediate filament	81818(Tax:10116)	24387(Tax:10116)	Gene	Gene	Modulation|nmod|START_ENTITY Modulation|acl|containing containing|dobj|distribution distribution|amod|END_ENTITY	Modulation of vimentin containing intermediate_filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase .
24447545	0	vimentin	16,24	miR-30a	40,47	vimentin	miR-30a	7431	407029	Gene	Gene	expression|compound|START_ENTITY expression|nmod|cells cells|amod|END_ENTITY	RUNX3 regulates vimentin expression via miR-30a during epithelial-mesenchymal transition in gastric_cancer cells .
11398835	0	vimentin	69,77	nestin	48,54	vimentin	nestin	7431	10763	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	The expression of intermediate_filament_protein nestin as related to vimentin and desmin in regenerating skeletal muscle .
2019567	1	vimentin	90,98	p34cdc2	67,74	vimentin	p34cdc2	7431	983	Gene	Gene	START_ENTITY|nsubj|phosphorylates phosphorylates|amod|END_ENTITY	p34cdc2 phosphorylates vimentin at a unique N-terminal site .
2169348	0	vimentin	94,102	p34cdc2	67,74	vimentin	p34cdc2	7431	983	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Intermediate filament reorganization during mitosis is mediated by p34cdc2 phosphorylation of vimentin .
25028191	0	vimentin	14,22	p53	92,95	vimentin	p53	7431	7157	Gene	Gene	Expression|nmod|START_ENTITY Expression|nmod|END_ENTITY	Expression of vimentin and survivin in clear_cell_renal_cell_carcinoma and correlation with p53 .
19117942	0	vimentin	31,39	rod_1	9,14	vimentin	rod 1	7431	9991	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Head and rod_1 interactions in vimentin : identification of contact sites , structure , and changes with phosphorylation using site-directed spin labeling and electron paramagnetic resonance .
12473693	0	vinculin	37,45	Arp2/3	19,25	vinculin	Arp2/3	7414	10097;10096	Gene	Gene	complex|nmod|START_ENTITY complex|amod|END_ENTITY	Recruitment of the Arp2/3 complex to vinculin : coupling membrane protrusion to matrix adhesion .
23974298	0	vinculin	28,36	CAS	0,3	vinculin	CAS	7414	9564	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics .
1711046	0	vinculin	38,46	Epidermal_growth_factor	0,23	vinculin	Epidermal growth factor	22330(Tax:10090)	13645(Tax:10090)	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Epidermal_growth_factor activation of vinculin and beta 1-integrin gene transcription in quiescent Swiss_3T3 cells .
3106082	0	vinculin	69,77	Insulin	0,7	vinculin	Insulin	7414	3630	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|amod|END_ENTITY	Insulin but not phorbol_ester treatment increases phosphorylation of vinculin by protein kinase C in BC3H-1 myocytes .
8922390	0	vinculin	152,160	LIM3	18,22	vinculin	LIM3	7414	8022	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal_adhesion_kinase binding .
19523901	0	vinculin	25,33	Raver1	0,6	vinculin	Raver1	7414	125950	Gene	Gene	interactions|nmod|START_ENTITY interactions|amod|END_ENTITY	Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions .
8836115	0	vinculin	100,108	VASP	58,62	vinculin	VASP	7414	7408	Gene	Gene	domain|nmod|START_ENTITY binds|nmod|domain binds|nsubj|vasodilator-stimulated_phosphoprotein vasodilator-stimulated_phosphoprotein|appos|END_ENTITY	The focal-adhesion vasodilator-stimulated_phosphoprotein -LRB- VASP -RRB- binds to the proline-rich domain in vinculin .
8980130	0	vinculin	22,30	VASP	0,4	vinculin	VASP	7414	7408	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	VASP interaction with vinculin : a recurring theme of interactions with proline-rich motifs .
1505973	0	vinculin	54,62	VCL	64,67	vinculin	VCL	7414	7414	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Complementary physical and genetic techniques map the vinculin -LRB- VCL -RRB- gene on chromosome 10q .
25115937	0	vinculin	28,36	Y1065	19,24	vinculin	Y1065	7414	1149211(Tax:187410)	Gene	Gene	Phosphorylation|nmod|START_ENTITY Phosphorylation|nmod|END_ENTITY	Phosphorylation at Y1065 in vinculin mediates actin bundling , cell spreading , and mechanical responses to force .
3113423	0	vinculin	24,32	alpha-actinin	38,51	vinculin	alpha-actinin	7414	87	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of vinculin with alpha-actinin .
7988684	0	vinculin	31,39	alpha-actinin	48,61	vinculin	alpha-actinin	7414	87	Gene	Gene	interactions|nmod|START_ENTITY control|nsubj|interactions control|dobj|END_ENTITY	Intramolecular interactions in vinculin control alpha-actinin binding to the vinculin head .
7988684	0	vinculin	77,85	alpha-actinin	48,61	vinculin	alpha-actinin	7414	87	Gene	Gene	head|compound|START_ENTITY control|nmod|head control|dobj|END_ENTITY	Intramolecular interactions in vinculin control alpha-actinin binding to the vinculin head .
8504798	0	vinculin	64,72	alpha-actinin	43,56	vinculin	alpha-actinin	7414	87	Gene	Gene	Evidence|amod|START_ENTITY Evidence|nmod|interaction interaction|nmod|END_ENTITY	Evidence for a ternary interaction between alpha-actinin , -LRB- meta -RRB- vinculin and acidic-phospholipid bilayers .
1924379	0	vinculin	52,60	alpha_catenin	33,46	vinculin	alpha catenin	22330(Tax:10090)	1495	Gene	Gene	homologue|compound|START_ENTITY homologue|nsubj|END_ENTITY	The uvomorulin-anchorage protein alpha_catenin is a vinculin homologue .
3130982	0	vinculin	47,55	protein_kinase_C	8,24	vinculin	protein kinase C	7414	112476	Gene	Gene	Role|nmod|START_ENTITY Role|nmod|END_ENTITY	Role of protein_kinase_C in phosphorylation of vinculin in adriamycin-resistant HL-60 leukemia cells .
16849320	0	viperin	46,53	BLIMP1	118,124	viperin	BLIMP1	91543	639	Gene	Gene	expression|compound|START_ENTITY END_ENTITY|dep|expression	Toll-like receptor-dependent and - independent viperin gene expression and counter-regulation by PRDI-binding_factor-1 / BLIMP1 .
16849320	0	viperin	46,53	PRDI-binding_factor-1	96,117	viperin	PRDI-binding factor-1	91543	639	Gene	Gene	expression|compound|START_ENTITY expression|dep|END_ENTITY	Toll-like receptor-dependent and - independent viperin gene expression and counter-regulation by PRDI-binding_factor-1 / BLIMP1 .
20483786	0	virus-induced_signaling_adaptor	37,68	RNF5	24,28	virus-induced signaling adaptor	RNF5	57506	6048	Gene	Gene	targets|dobj|START_ENTITY targets|nsubj|END_ENTITY	The E3 ubiquitin ligase RNF5 targets virus-induced_signaling_adaptor for ubiquitination and degradation .
23270673	0	visfatin	7,15	C-reactive_protein	85,103	visfatin	C-reactive protein	10135	1401	Gene	Gene	correlated|nsubjpass|START_ENTITY correlated|nmod|END_ENTITY	Plasma visfatin , associated with a genetic polymorphism -1535 C > T , is correlated with C-reactive_protein in Chinese Han patients with traumatic_brain_injury .
23670349	0	visfatin	36,44	Glucagon-like_peptide-1	0,23	visfatin	Glucagon-like peptide-1	10135	2641	Gene	Gene	expression|compound|START_ENTITY upregulates|dobj|expression upregulates|nsubj|END_ENTITY	Glucagon-like_peptide-1 upregulates visfatin expression in 3T3-L1 adipocytes .
24930994	0	visfatin	16,24	JAZF1	0,5	visfatin	JAZF1	10135	221895	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	JAZF1 regulates visfatin expression in adipocytes via PPARa and PPARb / signaling .
21542902	0	visfatin	59,67	JNK	83,86	visfatin	JNK	10135	5599	Gene	Gene	expression|compound|START_ENTITY expression|nmod|pathway pathway|compound|END_ENTITY	Tumor_necrosis_factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells .
19166999	0	visfatin	42,50	MCP-1	72,77	visfatin	MCP-1	10135	6347	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|secretion secretion|nmod|END_ENTITY	Pre-B_cell_colony_enhancing_factor -LRB- PBEF -RRB- / visfatin induces secretion of MCP-1 in human endothelial cells : role in visfatin-induced angiogenesis .
23953183	0	visfatin	58,66	NAMPT	68,73	visfatin	NAMPT	10135	10135	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of genetic variability in selected regions in visfatin -LRB- NAMPT -RRB- gene with anthropometric parameters and dietary composition in obese and non-obese Central-European population .
25918435	0	visfatin	32,40	NAMPT	25,30	visfatin	NAMPT	10135	10135	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and effect of NAMPT -LRB- visfatin -RRB- on progesterone secretion in hen granulosa cells .
25918435	0	visfatin	32,40	NAMPT	25,30	visfatin	NAMPT	10135	10135	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression and effect of NAMPT -LRB- visfatin -RRB- on progesterone secretion in hen granulosa cells .
16636125	0	visfatin	25,33	PBEF1	40,45	visfatin	PBEF1	10135	10135	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Genetic variation in the visfatin gene -LRB- PBEF1 -RRB- and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans .
21542902	0	visfatin	59,67	Tumor_necrosis_factor-a	0,23	visfatin	Tumor necrosis factor-a	10135	7124	Gene	Gene	expression|compound|START_ENTITY enhances|dobj|expression enhances|nsubj|END_ENTITY	Tumor_necrosis_factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells .
18460569	0	visfatin	66,74	adiponectin	53,64	visfatin	adiponectin	10135	9370	Gene	Gene	and_insulin_growth_factor-I|dep|START_ENTITY and_insulin_growth_factor-I|compound|END_ENTITY	Gender specificity of body adiposity and circulating adiponectin , visfatin , insulin , _ and_insulin_growth_factor-I at term birth : relation to prenatal growth .
20208458	0	visfatin	67,75	adiponectin	28,39	visfatin	adiponectin	10135	9370	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Relationships between serum adiponectin , apelin , leptin , resistin , visfatin levels and bone_mineral_density , and bone biochemical markers in post-menopausal Chinese women .
21738955	0	visfatin	66,74	adiponectin	26,37	visfatin	adiponectin	10135	9370	Gene	Gene	role|dep|START_ENTITY role|nmod|adipokines adipokines|compound|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
21738955	0	visfatin	66,74	adiponectin	26,37	visfatin	adiponectin	10135	9370	Gene	Gene	role|dep|START_ENTITY role|nmod|adipokines adipokines|compound|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
24059114	0	visfatin	28,36	adiponectin	15,26	visfatin	adiponectin	10135	9370	Gene	Gene	START_ENTITY|nsubj|leptin leptin|appos|END_ENTITY	-LSB- Serum leptin , adiponectin , visfatin levels in adult GHD patients and correlation studies -RSB- .
20208458	0	visfatin	67,75	apelin	41,47	visfatin	apelin	10135	8862	Gene	Gene	levels|dep|START_ENTITY levels|dep|END_ENTITY	Relationships between serum adiponectin , apelin , leptin , resistin , visfatin levels and bone_mineral_density , and bone biochemical markers in post-menopausal Chinese women .
21669562	0	visfatin	36,44	apelin	28,34	visfatin	apelin	10135	8862	Gene	Gene	adiponectin|dep|START_ENTITY adiponectin|compound|END_ENTITY	New adipocytokines -LRB- vaspin , apelin , visfatin , adiponectin -RRB- levels in children treated with valproic_acid .
23857051	0	visfatin	58,66	estrogen_receptor_a	11,30	visfatin	estrogen receptor a	10135	2099	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of estrogen_receptor_a and b on the expression of visfatin and retinol-binding_protein_4 in 3T3-L1 adipocytes .
21677044	0	visfatin	23,31	glucagon-like_peptide-1	101,124	visfatin	glucagon-like peptide-1	10135	2641	Gene	Gene	suppression|nmod|START_ENTITY evidence|nmod|suppression evidence|nmod|effect effect|nmod|END_ENTITY	In vivo suppression of visfatin by oral glucose uptake : evidence for a novel incretin-like effect by glucagon-like_peptide-1 -LRB- GLP-1 -RRB- .
17582143	0	visfatin	6,14	insulin	30,37	visfatin	insulin	10135	3630	Gene	Gene	START_ENTITY|nmod|resistance resistance|compound|END_ENTITY	Serum visfatin in relation to insulin resistance and markers of hyperandrogenism_in_lean_and_obese women with polycystic_ovary_syndrome .
25737638	0	visfatin	46,54	interleukin-6	31,44	visfatin	interleukin-6	10135	3569	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Effect of vitamin_D therapy on interleukin-6 , visfatin , and hyaluronic acid levels in chronic hepatitis_C Egyptian patients .
17884030	0	visfatin	59,67	leptin	41,47	visfatin	leptin	10135	3952	Gene	Gene	levels|dep|START_ENTITY levels|compound|END_ENTITY	Relationships between serum adiponectin , leptin , resistin , visfatin levels and bone mineral density , and bone biochemical markers in Chinese men .
19389835	0	visfatin	34,42	leptin	57,63	visfatin	leptin	10135	3952	Gene	Gene	production|compound|START_ENTITY production|nmod|END_ENTITY	In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose_tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways .
21738955	0	visfatin	66,74	leptin	18,24	visfatin	leptin	10135	3952	Gene	Gene	role|dep|START_ENTITY role|nmod|adipokines adipokines|compound|adiponectin adiponectin|compound|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
21738955	0	visfatin	66,74	leptin	18,24	visfatin	leptin	10135	3952	Gene	Gene	role|dep|START_ENTITY role|nmod|adipokines adipokines|compound|adiponectin adiponectin|compound|END_ENTITY	Potential role of leptin , adiponectin and three novel adipokines -- visfatin , chemerin and vaspin -- in chronic hepatitis .
8710169	0	visinin-like_protein	16,36	VILIP	38,43	visinin-like protein	VILIP	396189(Tax:9031)	396189(Tax:9031)	Gene	Gene	immunoreactivity|amod|START_ENTITY immunoreactivity|appos|END_ENTITY	Distribution of visinin-like_protein -LRB- VILIP -RRB- immunoreactivity in the hippocampus of the Mongolian gerbil -LRB- Meriones unguiculatus -RRB- .
25787039	0	vitamin-D_receptor	26,44	VDR	46,49	vitamin-D receptor	VDR	7421	7421	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genetic variations in the vitamin-D_receptor -LRB- VDR -RRB- gene in preeclampsia patients in the Chinese Han population .
12968673	0	vitamin_D-binding_protein	91,116	DBP	118,121	vitamin D-binding protein	DBP	2638	1628	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of molecular variants , haplotypes , and linkage disequilibrium within the human vitamin_D-binding_protein -LRB- DBP -RRB- gene with postmenopausal bone_mineral_density .
9179298	0	vitamin_D-binding_protein	30,55	Gc2	57,60	vitamin D-binding protein	Gc2	2638	83733	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	Bacterial expression of human vitamin_D-binding_protein -LRB- Gc2 -RRB- in functional form .
20120526	0	vitamin_D-receptor	91,109	Neuro-D	116,123	vitamin D-receptor	Neuro-D	7421	4760	Gene	Gene	receptor|amod|START_ENTITY receptor|amod|END_ENTITY	Retinopathy and nephropathy in type 1 diabetic patients -- association with polymorphysms of vitamin_D-receptor , TNF , Neuro-D and IL-1 receptor 1 genes .
20120526	0	vitamin_D-receptor	91,109	TNF	111,114	vitamin D-receptor	TNF	7421	7124	Gene	Gene	receptor|amod|START_ENTITY receptor|dep|END_ENTITY	Retinopathy and nephropathy in type 1 diabetic patients -- association with polymorphysms of vitamin_D-receptor , TNF , Neuro-D and IL-1 receptor 1 genes .
10426559	0	vitamin_D3-24-hydroxylase	144,169	CYP24	171,176	vitamin D3-24-hydroxylase	CYP24	25279(Tax:10116)	25279(Tax:10116)	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1 ,25 -LRB- OH -RRB- 2_vitamin_D3 -LRB- Falecalcitriol -RRB- in rat : induction of vitamin_D3-24-hydroxylase -LRB- CYP24 -RRB- responsible for 23S-hydroxylation in target tissues and the drop in serum levels .
10541881	0	vitamin_D3_25-hydroxylase	14,39	CYP27	41,46	vitamin D3 25-hydroxylase	CYP27	1593	1593	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Expression of vitamin_D3_25-hydroxylase -LRB- CYP27 -RRB- mRNA after induction by vitamin_D3 or UVB radiation in keratinocytes of human skin equivalents -- a preliminary study .
11579135	0	vitamin_D3_up-regulated_protein_1	58,91	VDUP1	93,98	vitamin D3 up-regulated protein 1	VDUP1	10628	10628	Gene	Gene	mRNA|amod|START_ENTITY mRNA|appos|END_ENTITY	Rapid induction and Ca -LRB- 2 + -RRB- influx-mediated suppression of vitamin_D3_up-regulated_protein_1 -LRB- VDUP1 -RRB- mRNA in cerebellar granule neurons undergoing apoptosis .
16624730	0	vitamin_D3_upregulated_protein-1	44,76	thioredoxin-binding_protein-2	14,43	vitamin D3 upregulated protein-1	thioredoxin-binding protein-2	10628	10628	Gene	Gene	Expression|dep|START_ENTITY Expression|nmod|END_ENTITY	Expression of thioredoxin-binding_protein-2 / vitamin_D3_upregulated_protein-1 in peripheral blood eosinophils of asthma patients .
9622151	0	vitamin_D_receptor	50,68	ANP	15,18	vitamin D receptor	ANP	7421	4878	Gene	Gene	transcription|nmod|START_ENTITY transcription|compound|END_ENTITY	Suppression of ANP gene transcription by liganded vitamin_D_receptor : involvement of specific receptor domains .
20015453	0	vitamin_D_receptor	67,85	Caveolin-3	23,33	vitamin D receptor	Caveolin-3	24873(Tax:10116)	29161(Tax:10116)	Gene	Gene	association|nmod|START_ENTITY association|dep|END_ENTITY	Membrane localization , Caveolin-3 association and rapid actions of vitamin_D_receptor in cardiac myocytes .
11450701	0	vitamin_D_receptor	94,112	Cdx-2	59,64	vitamin D receptor	Cdx-2	7421	1045	Gene	Gene	gene|compound|START_ENTITY element|nmod|gene END_ENTITY|dobj|element	The polymorphism in the caudal-related homeodomain protein Cdx-2 binding element in the human vitamin_D_receptor gene .
12968672	0	vitamin_D_receptor	55,73	Cdx-2	0,5	vitamin D receptor	Cdx-2	7421	1045	Gene	Gene	gene|compound|START_ENTITY region|nmod|gene polymorphism|nmod|region polymorphism|amod|END_ENTITY	Cdx-2 polymorphism in the promoter region of the human vitamin_D_receptor gene determines susceptibility to fracture in the elderly .
16362455	0	vitamin_D_receptor	41,59	Cdx-2	15,20	vitamin D receptor	Cdx-2	7421	1045	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	Effects of the Cdx-2 polymorphism of the vitamin_D_receptor gene and lifestyle factors on bone_mineral_density in a representative sample of Japanese women : the Japanese Population-based Osteoporosis -LRB- JPOS -RRB- Study .
23026509	0	vitamin_D_receptor	51,69	Cdx-2	25,30	vitamin D receptor	Cdx-2	7421	1045	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene polymorphism|compound|END_ENTITY	Vitamin_D status and the Cdx-2 polymorphism of the vitamin_D_receptor gene are determining factors of bone mineral density in young healthy postmenopausal women .
27067904	0	vitamin_D_receptor	51,69	Cdx-2	19,24	vitamin D receptor	Cdx-2	7421	1045	Gene	Gene	gene|compound|START_ENTITY polymorphism|nmod|gene I|dobj|polymorphism I|nsubj|role role|nmod|END_ENTITY	Regulatory role of Cdx-2 and Taq I polymorphism of vitamin_D_receptor gene on chemokine expression in pulmonary_tuberculosis .
9933478	0	vitamin_D_receptor	55,73	Cdx-2	39,44	vitamin D receptor	Cdx-2	7421	1045	Gene	Gene	expression|compound|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	The caudal-related homeodomain protein Cdx-2 regulates vitamin_D_receptor gene expression in the small intestine .
15885032	0	vitamin_D_receptor	12,30	FGF23	34,39	vitamin D receptor	FGF23	22337(Tax:10090)	64654(Tax:10090)	Gene	Gene	START_ENTITY|nmod|action action|compound|END_ENTITY	Role of the vitamin_D_receptor in FGF23 action on phosphate metabolism .
20138989	0	vitamin_D_receptor	37,55	Heat_shock_protein_90	0,21	vitamin D receptor	Heat shock protein 90	7421	3320	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Heat_shock_protein_90 interacts with vitamin_D_receptor in human leukemia cells .
23770368	0	vitamin_D_receptor	103,121	Insulin-like_growth_factor_binding_protein-3	0,44	vitamin D receptor	Insulin-like growth factor binding protein-3	7421	3486	Gene	Gene	modulates|nmod|START_ENTITY modulates|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein-3 modulates osteoblast differentiation via interaction with vitamin_D_receptor .
17595320	0	vitamin_D_receptor	64,82	Insulin-like_growth_factor_binding_protein-5	0,44	vitamin D receptor	Insulin-like growth factor binding protein-5	7421	3488	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Insulin-like_growth_factor_binding_protein-5 interacts with the vitamin_D_receptor and modulates the vitamin_D response in osteoblasts .
17054913	0	vitamin_D_receptor	36,54	LXRalpha	14,22	vitamin D receptor	LXRalpha	24873(Tax:10116)	58852(Tax:10116)	Gene	Gene	signaling|nmod|START_ENTITY END_ENTITY|acl|signaling	Inhibition of LXRalpha signaling by vitamin_D_receptor : possible role of VDR in bile_acid synthesis .
25969952	0	vitamin_D_receptor	24,42	MDM2	0,4	vitamin D receptor	MDM2	7421	4193	Gene	Gene	binds|dobj|START_ENTITY binds|nsubj|END_ENTITY	MDM2 binds and inhibits vitamin_D_receptor .
19229862	0	vitamin_D_receptor	48,66	Nup214	26,32	vitamin D receptor	Nup214	7421	8021	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Oncogenic nucleoporin_CAN / Nup214 interacts with vitamin_D_receptor and modulates its function .
22028889	0	vitamin_D_receptor	59,77	Osterix	41,48	vitamin D receptor	Osterix	22337(Tax:10090)	170574(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY increases|dobj|expression increases|nsubj|END_ENTITY	Osteoblast-specific transcription factor Osterix increases vitamin_D_receptor gene expression in osteoblasts .
21119599	0	vitamin_D_receptor	22,40	PTPH1	0,5	vitamin D receptor	PTPH1	7421	5774	Gene	Gene	cooperates|nmod|START_ENTITY cooperates|nsubj|END_ENTITY	PTPH1 cooperates with vitamin_D_receptor to stimulate breast_cancer growth through their mutual stabilization .
15769857	0	vitamin_D_receptor	36,54	Parathyroid_hormone	0,19	vitamin D receptor	Parathyroid hormone	22337(Tax:10090)	19226(Tax:10090)	Gene	Gene	expression|compound|START_ENTITY decreases|dobj|expression decreases|nsubj|END_ENTITY	Parathyroid_hormone decreases renal vitamin_D_receptor expression in vivo .
15322538	0	vitamin_D_receptor	41,59	SNAIL	25,30	vitamin D receptor	SNAIL	7421	6615	Gene	Gene	expression|compound|START_ENTITY represses|dobj|expression represses|nsubj|END_ENTITY	The transcription factor SNAIL represses vitamin_D_receptor expression and responsiveness in human colon_cancer .
15770204	0	vitamin_D_receptor	9,27	SNAIL	0,5	vitamin D receptor	SNAIL	7421	6615	Gene	Gene	expression|compound|START_ENTITY expression|compound|END_ENTITY	SNAIL vs vitamin_D_receptor expression in colon_cancer : therapeutics implications .
24926821	0	vitamin_D_receptor	59,77	TMPRSS2	20,27	vitamin D receptor	TMPRSS2	7421	7113	Gene	Gene	synergizes|nmod|START_ENTITY END_ENTITY|dep|synergizes	The prostate_cancer TMPRSS2 : ERG fusion synergizes with the vitamin_D_receptor -LRB- VDR -RRB- to induce CYP24A1 expression-limiting VDR signaling .
18261376	0	vitamin_D_receptor	27,45	VDR	47,50	vitamin D receptor	VDR	7421	7421	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	-LSB- Association between Fok I vitamin_D_receptor -LRB- VDR -RRB- gene polymorphism and plasmatic concentrations of transforming_growth_factor-beta1 and interferon_gamma in type 1 diabetes_mellitus -RSB- .
20419464	0	vitamin_D_receptor	10,28	VDR	30,33	vitamin D receptor	VDR	7421	7421	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of vitamin_D_receptor -LRB- VDR -RRB- genotypes on the risk for osteoporosis in type_1_Gaucher_disease .
22564539	0	vitamin_D_receptor	20,38	VDR	40,43	vitamin D receptor	VDR	7421	7421	Gene	Gene	Characterization|nmod|START_ENTITY Characterization|appos|END_ENTITY	Characterization of vitamin_D_receptor -LRB- VDR -RRB- in lung_adenocarcinoma .
22960018	0	vitamin_D_receptor	21,39	VDR	46,49	vitamin D receptor	VDR	7421	7421	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Investigation of the vitamin_D_receptor gene -LRB- VDR -RRB- and its interaction with protein_tyrosine_phosphatase , _ non-receptor_type_2_gene -LRB- PTPN2 -RRB- on risk of islet autoimmunity and type_1_diabetes : the Diabetes_Autoimmunity Study in the Young -LRB- DAISY -RRB- .
23352876	0	vitamin_D_receptor	26,44	VDR	46,49	vitamin D receptor	VDR	7421	7421	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Allelic variations of the vitamin_D_receptor -LRB- VDR -RRB- gene are associated with increased risk of coronary_artery_disease in type 2 diabetics : the DIABHYCAR prospective study .
25059118	0	vitamin_D_receptor	26,44	VDR	51,54	vitamin D receptor	VDR	7421	7421	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between Fok I vitamin_D_receptor gene -LRB- VDR -RRB- polymorphism and impulsivity in alcohol-dependent patients .
25661837	0	vitamin_D_receptor	20,38	VDR	40,43	vitamin D receptor	VDR	7421	7421	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Association between vitamin_D_receptor -LRB- VDR -RRB- gene polymorphisms and systemic_lupus_erythematosus in Portuguese patients .
25773805	0	vitamin_D_receptor	21,39	VDR	41,44	vitamin D receptor	VDR	7421	7421	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Associations between vitamin_D_receptor -LRB- VDR -RRB- gene polymorphisms and colorectal_cancer risk and effect modifications of dietary calcium and vitamin_D in a Japanese population .
26400282	0	vitamin_D_receptor	21,39	VDR	41,44	vitamin D receptor	VDR	7421	7421	Gene	Gene	Relationship|nmod|START_ENTITY Relationship|appos|END_ENTITY	Relationship between vitamin_D_receptor -LRB- VDR -RRB- polymorphisms and the efficacy of recombinant human growth_hormone -LRB- rhGH -RRB- treatment in children with idiopathic_short_stature .
9586948	0	vitamin_D_receptor	63,81	VDR	83,86	vitamin D receptor	VDR	7421	7421	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Inhibition of the 1,25-dihydroxyvitamin _ D3-induced increase in vitamin_D_receptor -LRB- VDR -RRB- levels and binding of VDR-retinoid_X_receptor -LRB- RXR -RRB- to a direct_repeat _ -LRB- DR -RRB- -3 type response element by an RXR-specific ligand in human keratinocyte cultures .
24316428	0	vitamin_D_receptor	14,32	VEGF	42,46	vitamin D receptor	VEGF	7421	7422	Gene	Gene	Activation|nmod|START_ENTITY promotes|nsubj|Activation promotes|dobj|expression expression|amod|END_ENTITY	Activation of vitamin_D_receptor promotes VEGF and CuZn-SOD expression in endothelial cells .
8990171	0	vitamin_D_receptor	14,32	YY1	0,3	vitamin D receptor	YY1	7421	7528	Gene	Gene	regulates|dobj|START_ENTITY regulates|nsubj|END_ENTITY	YY1 regulates vitamin_D_receptor / retinoid_X_receptor mediated transactivation of the vitamin_D responsive osteocalcin gene .
18082637	0	vitamin_D_receptor	65,83	apolipoprotein_A-I	27,45	vitamin D receptor	apolipoprotein A-I	7421	335	Gene	Gene	expression|nmod|START_ENTITY expression|amod|END_ENTITY	Differential regulation of apolipoprotein_A-I gene expression by vitamin_D_receptor modulators .
18832097	0	vitamin_D_receptor	26,44	caspase-3	48,57	vitamin D receptor	caspase-3	7421	836	Gene	Gene	Inactivation|nmod|START_ENTITY Inactivation|nmod|END_ENTITY	Inactivation of the human vitamin_D_receptor by caspase-3 .
20304057	0	vitamin_D_receptor	20,38	caveolin-3	44,54	vitamin D receptor	caveolin-3	24873(Tax:10116)	29161(Tax:10116)	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|nmod|END_ENTITY	Interaction between vitamin_D_receptor with caveolin-3 and regulation by 1,25-dihydroxyvitamin _ D3 in adult rat cardiomyocytes .
7876247	0	vitamin_D_receptor	4,22	general_transcription_factor_IIB	38,70	vitamin D receptor	general transcription factor IIB	7421	2959	Gene	Gene	interacts|nsubj|START_ENTITY interacts|nmod|END_ENTITY	The vitamin_D_receptor interacts with general_transcription_factor_IIB .
21871642	0	vitamin_D_receptor	15,33	insulin	58,65	vitamin D receptor	insulin	7421	3630	Gene	Gene	gene|compound|START_ENTITY Association|nmod|gene polymorphisms|nsubj|Association polymorphisms|nmod|resistance resistance|compound|END_ENTITY	Association of vitamin_D_receptor gene polymorphisms with insulin resistance and response to vitamin_D .
17716971	0	vitamin_D_receptor	27,45	p53	59,62	vitamin D receptor	p53	7421	7157	Gene	Gene	START_ENTITY|nmod|Family Family|compound|END_ENTITY	Differential regulation of vitamin_D_receptor -LRB- VDR -RRB- by the p53 Family : p73-dependent induction of VDR upon DNA damage .
10406465	0	vitamin_D_receptor	52,70	prolactin	30,39	vitamin D receptor	prolactin	7421	5617	Gene	Gene	promoter|nmod|START_ENTITY promoter|compound|END_ENTITY	Synergistic activation of the prolactin promoter by vitamin_D_receptor and GHF-1 : role of the coactivators , CREB-binding_protein and steroid_hormone_receptor_coactivator-1 -LRB- SRC-1 -RRB- .
26969398	0	vitamin_D_receptor	14,32	retinoic_acid_receptor_alpha	47,75	vitamin D receptor	retinoic acid receptor alpha	7421	5914	Gene	Gene	expression|compound|START_ENTITY Regulation|nmod|expression Regulation|nmod|END_ENTITY	Regulation of vitamin_D_receptor expression by retinoic_acid_receptor_alpha in acute_myeloid_leukemia cells .
9013769	0	vitamin_D_receptor	94,112	transcription_factor_IIB	25,49	vitamin D receptor	transcription factor IIB	7421	29105	Gene	Gene	required|nmod|START_ENTITY required|nsubjpass|domain domain|nmod|END_ENTITY	The N-terminal domain of transcription_factor_IIB is required for direct interaction with the vitamin_D_receptor and participates in vitamin_D-mediated transcription .
17059426	0	vitamin_K_epoxide_reductase_complex_subunit-1	6,51	VKORC1	53,59	vitamin K epoxide reductase complex subunit-1	VKORC1	79001	79001	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	A new vitamin_K_epoxide_reductase_complex_subunit-1 -LRB- VKORC1 -RRB- mutation in a patient with decreased stability of CYP2C9 enzyme .
821528	0	vitellogenin	16,28	albumin	39,46	vitellogenin	albumin	424533(Tax:9031)	396197(Tax:9031)	Gene	Gene	Localization|nmod|START_ENTITY END_ENTITY|nsubj|Localization	Localization of vitellogenin and serum albumin in hepatic parenchymal cells of normal and estradiol-treated immature chickens .
11054560	0	vitellogenin	12,24	vg3	31,34	vitellogenin	vg3	101882735	30518(Tax:7955)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	A zebrafish vitellogenin gene -LRB- vg3 -RRB- encodes a novel vitellogenin without a phosvitin domain and may represent a primitive vertebrate vitellogenin gene .
26923934	0	vitiligo	57,65	Aquaporin-3	34,45	vitiligo	Aquaporin-3	246319	360	Gene	Gene	protein|nmod|START_ENTITY protein|compound|END_ENTITY	Immunohistochemical expression of Aquaporin-3 protein in vitiligo ; a new potential guide for disease activity .
12447999	0	vitronectin	25,36	HT1080	91,97	vitronectin	HT1080	7448	8872	Gene	Gene	cell|amod|START_ENTITY cell|compound|END_ENTITY	Both u-PA inhibition and vitronectin binding by plasminogen_activator_inhibitor_1 regulate HT1080 fibrosarcoma cell metastasis .
7545714	0	vitronectin	16,27	IL-6	0,4	vitronectin	IL-6	29169(Tax:10116)	24498(Tax:10116)	Gene	Gene	expression|compound|START_ENTITY stimulates|dobj|expression stimulates|nsubj|END_ENTITY	IL-6 stimulates vitronectin gene expression in vivo .
18340378	0	vitronectin	86,97	MMP-2	68,73	vitronectin	MMP-2	7448	4313	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|compound|END_ENTITY	The initial steps of ovarian_cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin .
10764685	0	vitronectin	150,161	PAI-1	144,149	vitronectin	PAI-1	7448	5054	Gene	Gene	complexes|compound|START_ENTITY complexes|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
11266468	0	vitronectin	116,127	PAI-1	36,41	vitronectin	PAI-1	7448	5054	Gene	Gene	proteases|appos|START_ENTITY interaction|nmod|proteases controls|nmod|interaction controls|nsubj|END_ENTITY	The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases , not vitronectin .
11400167	0	vitronectin	39,50	PAI-1	60,65	vitronectin	PAI-1	7448	5054	Gene	Gene	START_ENTITY|dep|role role|nmod|END_ENTITY	Human endothelial cells grow poorly on vitronectin : role of PAI-1 .
12437099	0	vitronectin	67,78	PAI-1	114,119	vitronectin	PAI-1	7448	5054	Gene	Gene	PAI-1|nmod|START_ENTITY Interaction|nmod|PAI-1 Interaction|parataxis|mapping mapping|nmod|END_ENTITY	Interaction of plasminogen_activator_inhibitor_type-1 -LRB- PAI-1 -RRB- with vitronectin -LRB- Vn -RRB- : mapping the binding sites on PAI-1 and Vn .
12808446	0	vitronectin	4,15	PAI-1	22,27	vitronectin	PAI-1	7448	5054	Gene	Gene	binds|nsubj|START_ENTITY binds|xcomp|END_ENTITY	How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration .
1721912	0	vitronectin	86,97	PAI-1	56,61	vitronectin	PAI-1	7448	5054	Gene	Gene	complexed|nmod|START_ENTITY plasminogen_activator_inhibitor_1|acl:relcl|complexed plasminogen_activator_inhibitor_1|appos|END_ENTITY	Thrombin neutralizes plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- that is complexed with vitronectin in the endothelial cell matrix .
22700714	0	vitronectin	70,81	PAI-1	15,20	vitronectin	PAI-1	7448	5054	Gene	Gene	differentiation|nmod|START_ENTITY induces|dobj|differentiation induces|nsubj|uPA uPA|amod|END_ENTITY	uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin .
2467912	0	vitronectin	60,71	PAI-1	48,53	vitronectin	PAI-1	7448	5054	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|appos|END_ENTITY	Interaction of plasminogen activator inhibitor -LRB- PAI-1 -RRB- with vitronectin .
2470735	1	vitronectin	182,193	PAI-1	173,178	vitronectin	PAI-1	7448	5054	Gene	Gene	Demonstration|nmod|START_ENTITY Demonstration|nmod|binding binding|nmod|END_ENTITY	Demonstration of the binding , stabilization , and activation of PAI-1 by vitronectin .
7522053	0	vitronectin	42,53	PAI-1	20,25	vitronectin	PAI-1	7448	5054	Gene	Gene	site|nmod|START_ENTITY site|compound|END_ENTITY	Identification of a PAI-1 binding site in vitronectin .
7523190	0	vitronectin	21,32	PAI-1	84,89	vitronectin	PAI-1	7448	5054	Gene	Gene	site|compound|START_ENTITY site|nmod|plasminogen_activator_inhibitor_1 plasminogen_activator_inhibitor_1|appos|END_ENTITY	Determination of the vitronectin binding site on plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- .
8837777	0	vitronectin	88,99	PAI-1	11,16	vitronectin	PAI-1	7448	5054	Gene	Gene	blocking|nmod|START_ENTITY inhibits|advcl|blocking inhibits|nsubj|END_ENTITY	The serpin PAI-1 inhibits cell migration by blocking integrin_alpha_V_beta_3 binding to vitronectin .
1713175	0	vitronectin	20,31	Plasmin	0,7	vitronectin	Plasmin	7448	5340	Gene	Gene	cleavage|nmod|START_ENTITY cleavage|nsubj|END_ENTITY	Plasmin cleavage of vitronectin .
7556434	0	vitronectin	96,107	Plasmin	0,7	vitronectin	Plasmin	7448	5340	Gene	Gene	abrogates|nmod|START_ENTITY abrogates|nsubj|END_ENTITY	Plasmin abrogates alpha v beta_5-mediated adhesion of a human keratinocyte cell line -LRB- HaCaT -RRB- to vitronectin .
2433863	0	vitronectin	16,27	S-protein	29,38	vitronectin	S-protein	7448	7448	Gene	Gene	Localization|nmod|START_ENTITY Localization|dep|END_ENTITY	Localization of vitronectin -LRB- S-protein of complement -RRB- in normal human skin .
3238653	0	vitronectin	50,61	S-protein	63,72	vitronectin	S-protein	7448	7448	Gene	Gene	Interaction|nmod|START_ENTITY Interaction|dep|END_ENTITY	Interaction of thrombin-stimulated platelets with vitronectin -LRB- S-protein of complement -RRB- substrate : inhibition by a monoclonal antibody to glycoprotein_IIb-IIIa_complex .
8807714	0	vitronectin	61,72	Thrombin	0,8	vitronectin	Thrombin	7448	2147	Gene	Gene	role|nmod|START_ENTITY regulation|dep|role regulation|compound|END_ENTITY	Thrombin regulation by physiological inhibitors : the role of vitronectin .
1690718	0	vitronectin	101,112	beta_1	13,19	vitronectin	beta 1	7448	3779	Gene	Gene	receptor|compound|START_ENTITY form|dobj|receptor subunit|xcomp|form v|xcomp|subunit v|nsubj|associates associates|amod|END_ENTITY	The integrin beta_1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line .
1690718	0	vitronectin	48,59	beta_1	13,19	vitronectin	beta 1	7448	3779	Gene	Gene	alpha|compound|START_ENTITY associates|nmod|alpha associates|amod|END_ENTITY	The integrin beta_1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line .
7542669	0	vitronectin	33,44	beta_1	8,14	vitronectin	beta 1	7448	10678	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|END_ENTITY	Alpha v beta_1 is a receptor for vitronectin and fibrinogen , and acts with alpha 5 beta_1 to mediate spreading on fibronectin .
2442161	0	vitronectin	51,62	factor_Xa	84,93	vitronectin	factor Xa	7448	2159	Gene	Gene	START_ENTITY|nmod|inhibition inhibition|nmod|END_ENTITY	Neutralization and binding of heparin by S_protein / vitronectin in the inhibition of factor_Xa by antithrombin III .
1698627	0	vitronectin	24,35	glia-derived_nexin	78,96	vitronectin	glia-derived nexin	7448	5270	Gene	Gene	interaction|nmod|START_ENTITY interaction|nmod|END_ENTITY	Specific interaction of vitronectin with the cell-secreted protease inhibitor glia-derived_nexin and its thrombin complex .
15843372	0	vitronectin	68,79	granzyme_B	41,51	vitronectin	granzyme B	7448	3002	Gene	Gene	cleavage|nmod|START_ENTITY END_ENTITY|nmod|cleavage	Extracellular matrix remodeling by human granzyme_B via cleavage of vitronectin , fibronectin , and laminin .
7516895	0	vitronectin	42,53	mast_cell_protease_1	18,38	vitronectin	mast cell protease 1	29169(Tax:10116)	29265(Tax:10116)	Gene	Gene	Inhibition|nmod|START_ENTITY Inhibition|nmod|END_ENTITY	Inhibition of rat mast_cell_protease_1 by vitronectin .
9417058	0	vitronectin	7,18	matrix_metalloproteinase-2	27,53	vitronectin	matrix metalloproteinase-2	22370(Tax:10090)	17390(Tax:10090)	Gene	Gene	induces|nsubj|START_ENTITY induces|dobj|expression expression|amod|END_ENTITY	Intact vitronectin induces matrix_metalloproteinase-2 and tissue_inhibitor_of_metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells .
1376317	0	vitronectin	92,103	plasmin	205,212	vitronectin	plasmin	7448	5340	Gene	Gene	region|nmod:poss|START_ENTITY heparin|nmod|region sites|nmod|heparin Mapping|nmod|sites reveals|nsubj|Mapping reveals|dobj|mechanism mechanism|nmod|control control|nmod|formation formation|compound|END_ENTITY	Mapping of binding sites for heparin , plasminogen_activator_inhibitor-1 , and plasminogen to vitronectin 's heparin-binding region reveals a novel vitronectin-dependent feedback mechanism for the control of plasmin formation .
7678553	0	vitronectin	81,92	plasmin	56,63	vitronectin	plasmin	7448	5340	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	Synthetic peptides derived from the sequence around the plasmin cleavage site in vitronectin .
8612645	0	vitronectin	31,42	plasmin	8,15	vitronectin	plasmin	7448	5340	Gene	Gene	proteolysis|nmod|START_ENTITY proteolysis|compound|END_ENTITY	Limited plasmin proteolysis of vitronectin .
9030777	0	vitronectin	19,30	plasmin	88,95	vitronectin	plasmin	7448	5340	Gene	Gene	Phosphorylation|nmod|START_ENTITY attenuates|nsubj|Phosphorylation attenuates|nmod|END_ENTITY	Phosphorylation of vitronectin on Ser362 by protein_kinase_C attenuates its cleavage by plasmin .
9667615	0	vitronectin	92,103	plasmin	70,77	vitronectin	plasmin	7448	5340	Gene	Gene	generation|nmod|START_ENTITY generation|compound|END_ENTITY	Vitronectin expression in rheumatoid arthritic synovia -- inhibition of plasmin generation by vitronectin produced in vitro .
7482411	0	vitronectin	18,29	plasminogen_activator_inhibitor-1	48,81	vitronectin	plasminogen activator inhibitor-1	7448	5054	Gene	Gene	region|compound|START_ENTITY region|nmod|END_ENTITY	Localization of a vitronectin binding region of plasminogen_activator_inhibitor-1 .
7523190	0	vitronectin	21,32	plasminogen_activator_inhibitor_1	49,82	vitronectin	plasminogen activator inhibitor 1	7448	5054	Gene	Gene	site|compound|START_ENTITY site|nmod|END_ENTITY	Determination of the vitronectin binding site on plasminogen_activator_inhibitor_1 -LRB- PAI-1 -RRB- .
17504807	0	vitronectin	40,51	prion_protein	9,22	vitronectin	prion protein	22370(Tax:10090)	19122(Tax:10090)	Gene	Gene	interaction|nmod|START_ENTITY interaction|compound|END_ENTITY	Cellular prion_protein interaction with vitronectin supports axonal_growth and is compensated by integrins .
15157085	0	vitronectin	84,95	somatomedin_B	54,67	vitronectin	somatomedin B	7448	7448	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Disulfide bonding arrangements in active forms of the somatomedin_B domain of human vitronectin .
15173163	0	vitronectin	83,94	somatomedin_B	52,65	vitronectin	somatomedin B	7448	7448	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	Assignment of the four disulfides in the N-terminal somatomedin_B domain of native vitronectin isolated from human plasma .
16519524	0	vitronectin	47,58	somatomedin_B	23,36	vitronectin	somatomedin B	7448	7448	Gene	Gene	domain|nmod|START_ENTITY domain|compound|END_ENTITY	The reduced , denatured somatomedin_B domain of vitronectin refolds into a stable , biologically active molecule .
17189256	0	vitronectin	76,87	somatomedin_B	46,59	vitronectin	somatomedin B	7448	7448	Gene	Gene	domain|nmod|START_ENTITY domain|amod|END_ENTITY	Defining the native disulfide topology in the somatomedin_B domain of human vitronectin .
17344041	0	vitronectin	49,60	somatomedin_B	25,38	vitronectin	somatomedin B	7448	7448	Gene	Gene	region|nmod|START_ENTITY region|amod|END_ENTITY	The uPA receptor and the somatomedin_B region of vitronectin direct the localization of uPA to focal adhesions in microvessel endothelial cells .
10764685	0	vitronectin	150,161	thrombin	123,131	vitronectin	thrombin	7448	2147	Gene	Gene	complexes|compound|START_ENTITY activity|nmod|complexes activity|compound|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
10764685	0	vitronectin	150,161	thrombin	18,26	vitronectin	thrombin	7448	2147	Gene	Gene	complexes|compound|START_ENTITY activity|nmod|complexes mechanism|nmod|activity Colocalization|dep|mechanism Colocalization|nmod|END_ENTITY	Colocalization of thrombin , PAI-1 , and vitronectin in the atherosclerotic vessel wall : A potential regulatory mechanism of thrombin activity by PAI-1 / vitronectin complexes .
10722842	0	vitronectin	88,99	uPAR	36,40	vitronectin	uPAR	22370(Tax:10090)	18793(Tax:10090)	Gene	Gene	cell|nmod|START_ENTITY required|nmod|cell required|nsubjpass|Domain Domain|nmod|urokinase_receptor urokinase_receptor|appos|END_ENTITY	Domain 1 of the urokinase_receptor -LRB- uPAR -RRB- is required for uPAR-mediated cell binding to vitronectin .
7528215	2	vitronectin	360,371	uPAR	304,308	vitronectin	uPAR	7448	5329	Gene	Gene	receptor|nmod|START_ENTITY receptor|nsubj|urokinase_receptor urokinase_receptor|appos|END_ENTITY	We now report that the urokinase_receptor -LRB- uPAR -RRB- is also a high affinity -LRB- Kd < 30 nM -RRB- receptor for vitronectin .
7528215	0	vitronectin	69,80	urokinase_receptor	22,40	vitronectin	urokinase receptor	7448	5329	Gene	Gene	Identification|nmod|START_ENTITY Identification|nmod|END_ENTITY	Identification of the urokinase_receptor as an adhesion receptor for vitronectin .
15069014	0	vitronectin	144,155	vitronectin	20,31	vitronectin	vitronectin	7448	7448	Gene	Gene	involved|nmod|START_ENTITY involved|nsubjpass|END_ENTITY	Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin .
15069014	0	vitronectin	20,31	vitronectin	144,155	vitronectin	vitronectin	7448	7448	Gene	Gene	involved|nsubjpass|START_ENTITY involved|nmod|END_ENTITY	Fibrin-incorporated vitronectin is involved in platelet adhesion and thrombus formation through homotypic interactions with platelet-associated vitronectin .
18367731	0	vldlr	41,46	VLDL	22,26	vldlr	VLDL	22359(Tax:10090)	54219(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	The hepatic uptake of VLDL in lrp-ldlr - / - vldlr - / - mice is regulated by LPL activity and involves proteoglycans and SR-BI .
19441085	0	vmhc	93,97	ventricular_myosin_heavy_chain	61,91	vmhc	ventricular myosin heavy chain	30616(Tax:7955)	30616(Tax:7955)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Isolation of a ventricle-specific promoter for the zebrafish ventricular_myosin_heavy_chain -LRB- vmhc -RRB- gene and its regulation by GATA factors during embryonic heart development .
19517572	0	vmhc	53,57	ventricular_myosin_heavy_chain	21,51	vmhc	ventricular myosin heavy chain	30616(Tax:7955)	30616(Tax:7955)	Gene	Gene	analysis|dep|START_ENTITY analysis|nmod|END_ENTITY	Promoter analysis of ventricular_myosin_heavy_chain -LRB- vmhc -RRB- in zebrafish embryos .
16674563	0	vocal_cord_and_pharyngeal_weakness_with_distal_myopathy	39,94	Myotilin	0,8	vocal cord and pharyngeal weakness with distal myopathy	Myotilin	9782	9499	Gene	Gene	gene|nmod|START_ENTITY gene|nsubj|END_ENTITY	Myotilin is not the causative gene for vocal_cord_and_pharyngeal_weakness_with_distal_myopathy -LRB- VCPDM -RRB- .
9271262	0	voltage-dependent_anion-selective_channel	44,85	VDAC	87,91	voltage-dependent anion-selective channel	VDAC	34500(Tax:7227)	34500(Tax:7227)	Gene	Gene	characterization|nmod|START_ENTITY characterization|appos|END_ENTITY	Cloning and molecular characterization of a voltage-dependent_anion-selective_channel -LRB- VDAC -RRB- from Drosophila_melanogaster .
15757910	0	voltage-dependent_anion_channel_2	35,68	Bak	28,31	voltage-dependent anion channel 2	Bak	7417	578	Gene	Gene	regulation|nmod|START_ENTITY regulation|nmod|END_ENTITY	Bax-dependent regulation of Bak by voltage-dependent_anion_channel_2 .
8177498	0	voltage-gated_Ca_channel	25,49	Endothelin-3	0,12	voltage-gated Ca channel	Endothelin-3	246215(Tax:10116)	366270(Tax:10116)	Gene	Gene	activates|dobj|START_ENTITY activates|nsubj|END_ENTITY	Endothelin-3 activates a voltage-gated_Ca_channel via a pertussis toxin sensitive mechanism leading to dopamine release from PC12 cells .
9143495	0	voltage-gated_sodium_channel	78,106	Scn10a	113,119	voltage-gated sodium channel	Scn10a	20264(Tax:10090)	20264(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Cloning and characterization of a mouse sensory neuron tetrodotoxin-resistant voltage-gated_sodium_channel gene , Scn10a .
15735809	0	von-Willebrand-factor-cleaving_protease	21,60	ADAMTS13	11,19	von-Willebrand-factor-cleaving protease	ADAMTS13	11093	11093	Gene	Gene	activity|dep|START_ENTITY activity|compound|END_ENTITY	Changes in ADAMTS13 -LRB- von-Willebrand-factor-cleaving_protease -RRB- activity after induced release of von_Willebrand_factor_during_acute_systemic_inflammation .
10441001	0	von_Hippel-Lindau	89,106	CUL2	141,145	von Hippel-Lindau	CUL2	7428	8453	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Genomic organization and chromosomal localization of the human CUL2 gene and the role of von_Hippel-Lindau tumor suppressor-binding protein -LRB- CUL2 and VBP1 -RRB- mutation and loss in renal-cell_carcinoma development .
10830910	0	von_Hippel-Lindau	66,83	VHL	85,88	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genotype-phenotype correlations in families with deletions in the von_Hippel-Lindau -LRB- VHL -RRB- gene .
11585776	0	von_Hippel-Lindau	19,36	VHL	38,41	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Effects of ras and von_Hippel-Lindau -LRB- VHL -RRB- gene mutations on hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 alpha , HIF-2alpha , and vascular_endothelial_growth_factor expression and their regulation by the phosphatidylinositol_3 ' - kinase/Akt signaling pathway .
11967908	0	von_Hippel-Lindau	17,34	VHL	36,39	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutations in the von_Hippel-Lindau -LRB- VHL -RRB- gene refine differential diagnostic criteria in renal_cell_carcinoma .
14767077	0	von_Hippel-Lindau	131,148	VHL	126,129	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	protein|appos|START_ENTITY protein|compound|END_ENTITY	Combination of multiple alignment analysis and surface mapping paves a way for a detailed pathway reconstruction -- the case of VHL -LRB- von_Hippel-Lindau -RRB- protein and angiogenesis regulatory pathway .
14965365	0	von_Hippel-Lindau	16,33	VHL	35,38	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Mutation of the von_Hippel-Lindau -LRB- VHL -RRB- gene in human colorectal_carcinoma : association with cytoplasmic accumulation of hypoxia-inducible_factor _ -LRB- HIF -RRB- -1 alpha .
16884328	0	von_Hippel-Lindau	53,70	VHL	72,75	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Molecular characterization of large deletions in the von_Hippel-Lindau -LRB- VHL -RRB- gene by quantitative real-time PCR : the hypothesis of an alu-mediated mechanism underlying VHL gene rearrangements .
17102087	0	von_Hippel-Lindau	21,38	VHL	40,43	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Germline mutation of von_Hippel-Lindau -LRB- VHL -RRB- gene 695_G > A -LRB- R161Q -RRB- in a patient with a peculiar phenotype with type 2C VHL_syndrome .
18481984	0	von_Hippel-Lindau	17,34	VHL	12,15	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Role of the VHL -LRB- von_Hippel-Lindau -RRB- gene in renal cancer : a multifunctional tumour suppressor .
19933033	0	von_Hippel-Lindau	43,60	VHL	62,65	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Identification of somatic mutations in the von_Hippel-Lindau -LRB- VHL -RRB- gene in a patient with renal_cell_carcinoma .
22357874	0	von_Hippel-Lindau	30,47	VHL	49,52	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Agents that stabilize mutated von_Hippel-Lindau -LRB- VHL -RRB- protein : results of a high-throughput screen to identify compounds that modulate VHL proteostasis .
23626751	0	von_Hippel-Lindau	11,28	VHL	30,33	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	mutation|amod|START_ENTITY mutation|appos|END_ENTITY	P.Arg82Leu von_Hippel-Lindau -LRB- VHL -RRB- gene mutation among three members of a family with familial_bilateral_pheochromocytoma in India : molecular analysis and in silico characterization .
24727139	0	von_Hippel-Lindau	40,57	VHL	59,62	von Hippel-Lindau	VHL	7428	7428	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Unique molecular alteration patterns in von_Hippel-Lindau -LRB- VHL -RRB- gene in a cohort of sporadic_renal_cell_carcinoma patients from Pakistan .
15386385	0	von_Hippel-Lindau	0,17	thrombin	58,66	von Hippel-Lindau	thrombin	7428	2147	Gene	Gene	stimulation|amod|START_ENTITY stimulation|nmod|END_ENTITY	von_Hippel-Lindau tumor suppressor protein stimulation by thrombin involves RhoA activation .
20632125	0	von_Hippel-Lindau	4,21	tumor-suppressor	28,44	von Hippel-Lindau	tumor-suppressor	7428	7248	Gene	Gene	_|amod|START_ENTITY _|nsubj|_ _|ccomp|down-regulated down-regulated|nsubjpass|gene gene|amod|END_ENTITY	The von_Hippel-Lindau _ -LRB- VHL -RRB- _ tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa .
15569457	0	von_Hippel-Lindau	13,30	vascular_endothelial_growth_factor	54,88	von Hippel-Lindau	vascular endothelial growth factor	7428	7422	Gene	Gene	gene|amod|START_ENTITY gene|nmod|END_ENTITY	-LSB- Mutation of von_Hippel-Lindau gene and expression of vascular_endothelial_growth_factor in sporadic_clear_cell_renal_cell_carcinoma and their relationships to angiogenesis -RSB- .
9931330	0	von_Hippel-Lindau-binding_protein-1	18,53	Vbp1	55,59	von Hippel-Lindau-binding protein-1	Vbp1	22327(Tax:10090)	22327(Tax:10090)	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the von_Hippel-Lindau-binding_protein-1 -LRB- Vbp1 -RRB- in fetal and adult mouse tissues .
11081202	0	von_Hippel-Lindau_protein	14,39	VHL-P	41,46	von Hippel-Lindau protein	VHL-P	391104	391104	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of von_Hippel-Lindau_protein -LRB- VHL-P -RRB- in nontumorous and adenomatous human pituitaries .
15955559	0	von_Hippel_Lindau	14,31	pVHL	33,37	von Hippel Lindau	pVHL	7428	7428	Gene	Gene	protein|amod|START_ENTITY protein|dep|END_ENTITY	Expression of von_Hippel_Lindau -LRB- pVHL -RRB- protein in placentae from normal pregnant women and women with preeclampsia .
25341886	0	von_Willebrand_Factor	26,47	GpIba	9,14	von Willebrand Factor	GpIba	7450	2811	Gene	Gene	binding|nmod|START_ENTITY END_ENTITY|amod|binding	Platelet GpIba binding to von_Willebrand_Factor under fluid shear : contributions of the D D3-domain , A1-domain flanking peptide and O-linked glycans .
12393397	0	von_Willebrand_factor	52,73	ADAMTS-13	0,9	von Willebrand factor	ADAMTS-13	7450	11093	Gene	Gene	multimers|compound|START_ENTITY cleaves|dobj|multimers cleaves|nsubj|END_ENTITY	ADAMTS-13 rapidly cleaves newly secreted ultralarge von_Willebrand_factor multimers on the endothelial surface under flowing conditions .
14995983	0	von_Willebrand_factor	20,41	ADAMTS-13	60,69	von Willebrand factor	ADAMTS-13	7450	11093	Gene	Gene	cleaving|compound|START_ENTITY activity|nmod|cleaving protease|nsubj|activity protease|dobj|END_ENTITY	The activity of the von_Willebrand_factor cleaving protease ADAMTS-13 in newborn infants .
15774619	0	von_Willebrand_factor	36,57	ADAMTS-13	93,102	von Willebrand factor	ADAMTS-13	7450	11093	Gene	Gene	multimers|nmod|START_ENTITY Cleavage|nmod|multimers Cleavage|nmod|mutants mutants|nmod|END_ENTITY	Cleavage of ultralarge multimers of von_Willebrand_factor by C-terminal-truncated mutants of ADAMTS-13 under flow .
19765212	0	von_Willebrand_factor	35,56	ADAMTS-13	22,31	von Willebrand factor	ADAMTS-13	7450	11093	Gene	Gene	binding|nmod|START_ENTITY binding|nmod|END_ENTITY	Multi-step binding of ADAMTS-13 to von_Willebrand_factor .
23682841	0	von_Willebrand_factor	19,40	ADAMTS-13	44,53	von Willebrand factor	ADAMTS-13	7450	11093	Gene	Gene	cleavage|nmod|START_ENTITY Normal|dobj|cleavage Normal|nmod|END_ENTITY	Normal cleavage of von_Willebrand_factor by ADAMTS-13 in the absence of factor VIII in patients with severe hemophilia __ A.
22908929	0	von_Willebrand_factor	24,45	Factor_VIII	0,11	von Willebrand factor	Factor VIII	7450	2157	Gene	Gene	makes|nsubj|START_ENTITY inhibitors|parataxis|makes inhibitors|nsubj|END_ENTITY	Factor_VIII inhibitors : von_Willebrand_factor makes a difference in vitro and in vivo .
18752579	0	von_Willebrand_factor	32,53	Protein_kinase_C-delta	0,22	von Willebrand factor	Protein kinase C-delta	7450	5580	Gene	Gene	START_ENTITY|nsubj|mediates mediates|amod|END_ENTITY	Protein_kinase_C-delta mediates von_Willebrand_factor secretion from endothelial cells in response to vascular_endothelial_growth_factor -LRB- VEGF -RRB- but not histamine .
23690449	0	von_Willebrand_factor	16,37	VWF	39,42	von Willebrand factor	VWF	7450	7450	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Common and rare von_Willebrand_factor -LRB- VWF -RRB- coding variants , VWF levels , and factor_VIII levels in African Americans : the NHLBI Exome Sequencing Project .
17376515	0	von_Willebrand_factor	0,21	factor_VIII	103,114	von Willebrand factor	factor VIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	modulate|nsubj|START_ENTITY modulate|nmod|END_ENTITY	von_Willebrand_factor and transforming growth factor-beta modulate immune response against coagulation factor_VIII in FVIII-deficient mice .
2104761	0	von_Willebrand_factor	6,27	factor_VIII	59,70	von Willebrand factor	factor VIII	7450	2157	Gene	Gene	_|compound|START_ENTITY _|nsubj|_ _|dobj|defect defect|nmod|deficiency deficiency|amod|patient patient|nmod|END_ENTITY	A new von_Willebrand_factor _ -LRB- vWF -RRB- _ defect in a patient with factor_VIII -LRB- FVIII -RRB- deficiency but with normal levels and multimeric patterns of both plasma and platelet vWF .
22044692	0	von_Willebrand_factor	27,48	factor_VIII	69,80	von Willebrand factor	factor VIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	effect|nmod|START_ENTITY effect|nmod|END_ENTITY	Immunoprotective effect of von_Willebrand_factor towards therapeutic factor_VIII in experimental haemophilia_A .
24850761	0	von_Willebrand_factor	2,23	factor_VIII	100,111	von Willebrand factor	factor VIII	22371(Tax:10090)	14069(Tax:10090)	Gene	Gene	fragment|compound|START_ENTITY sufficient|nsubj|fragment sufficient|xcomp|stabilize stabilize|dobj|END_ENTITY	A von_Willebrand_factor fragment containing the D'D3 domains is sufficient to stabilize coagulation factor_VIII in mice .
17273877	0	von_Willebrand_factor	40,61	vWF	63,66	von Willebrand factor	vWF	7450	7450	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Complex variability of intron 40 of the von_Willebrand_factor -LRB- vWF -RRB- gene .
15583740	0	von_Willebrand_factor-cleaving_protease	0,39	ADAMTS13	41,49	von Willebrand factor-cleaving protease	ADAMTS13	11093	11093	Gene	Gene	activity|amod|START_ENTITY activity|appos|END_ENTITY	von_Willebrand_factor-cleaving_protease -LRB- ADAMTS13 -RRB- activity in normal non-pregnant women , pregnant and post-delivery women .
18295305	0	von_Willebrand_factor-cleaving_protease	18,57	ADAMTS13	59,67	von Willebrand factor-cleaving protease	ADAMTS13	11093	11093	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Changes in plasma von_Willebrand_factor-cleaving_protease -LRB- ADAMTS13 -RRB- levels in patients with unstable_angina .
20135067	0	von_Willebrand_factor-cleaving_protease	27,66	ADAMTS13	68,76	von Willebrand factor-cleaving protease	ADAMTS13	11093	11093	Gene	Gene	levels|amod|START_ENTITY levels|appos|END_ENTITY	Prognostic value of plasma von_Willebrand_factor-cleaving_protease -LRB- ADAMTS13 -RRB- antigen levels in patients with coronary_artery_disease .
21556619	0	vpf	58,61	vascular-permeability_factor	28,56	vpf	vascular-permeability factor	7422	7422	Gene	Gene	expression|appos|START_ENTITY expression|amod|END_ENTITY	The selective-inhibition of vascular-permeability_factor -LRB- vpf -RRB- expression in ovarian-carcinoma cell-lines by gonadotropin-releasing-hormone -LRB- GnRH -RRB- agonist .
21556561	0	waf-1	125,130	p53	88,91	waf-1	p53	12575(Tax:10090)	22060(Tax:10090)	Gene	Gene	induction|nmod|START_ENTITY END_ENTITY|dep|induction	Status of the mdm-2 and waf-1 genes in mouse epidermal jb6 variants harboring wild-type p53 - a p53-independent induction of waf-1 .
10906181	0	waf1	22,26	p21	18,21	waf1	p21	1026	1026	Gene	Gene	Overexpression|appos|START_ENTITY Overexpression|nmod|END_ENTITY	Overexpression of p21 -LRB- waf1 -RRB- in human_T-cell_lymphotropic_virus_type_1-infected cells and its association with cyclin_A / cdk2 .
11574165	0	waf1	34,38	p21	30,33	waf1	p21	1026	1026	Gene	Gene	promoter|appos|START_ENTITY promoter|amod|END_ENTITY	Transcriptional repression of p21 -LRB- waf1 -RRB- promoter by hepatitis_B_virus X protein via a p53-independent pathway .
17412493	0	waf1	135,139	p21	131,134	waf1	p21	1026	1026	Gene	Gene	upregulation|appos|START_ENTITY upregulation|compound|END_ENTITY	1alpha,25-Dihydroxyvitamin _ D -LRB- 3 -RRB- antiproliferative actions involve vitamin_D_receptor-mediated activation of MAPK pathways and AP-1 / p21 -LRB- waf1 -RRB- upregulation in human osteosarcoma .
20600642	0	waf1	20,24	p21	15,18	waf1	p21	1026	1026	Gene	Gene	Involvement|appos|START_ENTITY Involvement|nmod|END_ENTITY	Involvement of p21 -LRB- waf1 -RRB- in merlin deficient sporadic_vestibular_schwannomas .
21552919	0	waf1	33,37	p21	29,32	waf1	p21	1026	1026	Gene	Gene	induction|appos|START_ENTITY induction|nmod|END_ENTITY	P53-independent induction of p21 -LRB- waf1 -RRB- pathway is preserved during tumor progression .
10347252	0	waf1	22,26	p53	122,125	waf1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY Overexpression|nmod|p21 decreases|nsubj|Overexpression decreases|dobj|arrest arrest|acl|induced induced|xcomp|lacking lacking|dobj|protein protein|amod|END_ENTITY	Overexpression of p21 -LRB- waf1 -RRB- decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein .
11237596	0	waf1	57,61	p53	83,86	waf1	p53	1026	7157	Gene	Gene	element|amod|START_ENTITY containing|dobj|element containing|nmod|protein protein|compound|END_ENTITY	Conformation_and_rigidity of DNA microcircles containing waf1 response element for p53 regulatory protein .
22825333	0	waf1	32,36	p53	86,89	waf1	p53	1026	7157	Gene	Gene	p21|appos|START_ENTITY regulation|nmod|p21 protein|nsubj|regulation protein|nmod|tumors tumors|nummod|END_ENTITY	Differential regulation of p21 -LRB- waf1 -RRB- protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications .
10606183	0	waf1-cip1	45,54	p21	40,43	waf1-cip1	p21	1026	1026	Gene	Gene	protein|dep|START_ENTITY protein|amod|END_ENTITY	Expression of bcl-2 , c-erbB-2 , p53 , and p21 -LRB- waf1-cip1 -RRB- protein in thyroid_carcinomas .
7533293	0	waved-2	54,61	epidermal_growth_factor_receptor	18,50	waved-2	epidermal growth factor receptor	13649(Tax:10090)	13649(Tax:10090)	Gene	Gene	mice|amod|START_ENTITY END_ENTITY|nmod|mice	A mutation in the epidermal_growth_factor_receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired_lactation .
22797065	0	wee1	30,34	Cdk1	21,25	wee1	Cdk1	7465	983	Gene	Gene	inhibition|amod|START_ENTITY END_ENTITY|nmod|inhibition	Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination .
17109819	0	wee1	40,44	TBP-related_factor_2	53,73	wee1	TBP-related factor 2	22390(Tax:10090)	237336(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY repression|nmod|gene repression|nmod|END_ENTITY	Transcriptional repression of the mouse wee1 gene by TBP-related_factor_2 .
1850698	0	wee1	61,65	p34cdc2	48,55	wee1	p34cdc2	7465	983	Gene	Gene	manner|amod|START_ENTITY END_ENTITY|nmod|manner	Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1 + dependent manner .
11326419	0	whey_acidic_protein	82,101	WAP	103,106	whey acidic protein	WAP	22373(Tax:10090)	22373(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	A transgenic mouse model for investigating the response of the upstream region of whey_acidic_protein -LRB- WAP -RRB- gene to various steroid hormones .
17692477	0	whey_acidic_protein	26,45	WAP	47,50	whey acidic protein	WAP	396835(Tax:9823)	396835(Tax:9823)	Gene	Gene	control|nmod|START_ENTITY control|appos|END_ENTITY	Distal control of the pig whey_acidic_protein -LRB- WAP -RRB- locus in transgenic_mice .
7576607	0	whey_acidic_protein	14,33	WAP	35,38	whey acidic protein	WAP	22373(Tax:10090)	22373(Tax:10090)	Gene	Gene	genes|amod|START_ENTITY genes|appos|END_ENTITY	Expression of whey_acidic_protein -LRB- WAP -RRB- genes in tissues other than the mammary gland in normal and transgenic_mice expressing mWAP/hGH fusion gene .
2186946	0	whey_acidic_protein	28,47	Wap	49,52	whey acidic protein	Wap	22373(Tax:10090)	22373(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Induction of the endogenous whey_acidic_protein -LRB- Wap -RRB- gene and a Wap-myc hybrid gene in primary murine mammary organoids .
22405851	0	wild-type_p53-induced_phosphatase_1	30,65	Wip1	67,71	wild-type p53-induced phosphatase 1	Wip1	8493	8493	Gene	Gene	expression|nmod|START_ENTITY expression|appos|END_ENTITY	p53-Independent expression of wild-type_p53-induced_phosphatase_1 -LRB- Wip1 -RRB- in methylmethane_sulfonate-treated cancer cell lines and human tumors .
10756097	0	wildtype_p53-induced_phosphatase_1	43,77	Wip1	79,83	wildtype p53-induced phosphatase 1	Wip1	8493	53892(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	The structure and expression of the murine wildtype_p53-induced_phosphatase_1 -LRB- Wip1 -RRB- gene .
19895723	0	wingless-type_MMTV_integration_site_family_member_2	47,98	WNT2	101,105	wingless-type MMTV integration site family member 2	WNT2	7472	7472	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association between autism and variants in the wingless-type_MMTV_integration_site_family_member_2 -LRB- WNT2 -RRB- gene .
23653377	0	wingless-type_MMTV_integration_site_family_member_5a	60,112	Wnt5a	114,119	wingless-type MMTV integration site family member 5a	Wnt5a	7474	7474	Gene	Gene	levels|amod|START_ENTITY levels|amod|END_ENTITY	Circulating secreted frizzled-related protein 5 -LRB- Sfrp5 -RRB- and wingless-type_MMTV_integration_site_family_member_5a -LRB- Wnt5a -RRB- levels in patients with type_2_diabetes_mellitus .
1377452	0	wnt-2	39,44	irp	46,49	wnt-2	irp	114487(Tax:10116)	25402(Tax:10116)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Growth and developmental regulation of wnt-2 -LRB- irp -RRB- gene in mesenchymal cells of fetal lung .
20564202	0	wnt11	23,28	Jnk	43,46	wnt11	Jnk	791595(Tax:7955)	65236(Tax:7955)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation .
12554773	0	wnt4	146,150	Dax-1	0,5	wnt4	Dax-1	22417(Tax:10090)	11614(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	Dax-1 -LRB- dosage-sensitive_sex_reversal-adrenal_hypoplasia_congenita critical region on the X chromosome , gene 1 -RRB- gene transcription is regulated by wnt4 in the female developing gonad .
19523951	0	wolframin	37,46	WFS1	48,52	wolframin	WFS1	22393(Tax:10090)	7466	Gene	Gene	Expression|nmod|START_ENTITY Expression|appos|END_ENTITY	Expression of the diabetes risk gene wolframin -LRB- WFS1 -RRB- in the human retina .
21031341	0	wolframin	68,77	Wfs1	79,83	wolframin	Wfs1	22393(Tax:10090)	22393(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Sex differences in the development of diabetes in mice with deleted wolframin -LRB- Wfs1 -RRB- gene .
24710642	0	wolframin	60,69	Wfs1	71,75	wolframin	Wfs1	22393(Tax:10090)	22393(Tax:10090)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Energy metabolism and thyroid function of mice with deleted wolframin -LRB- Wfs1 -RRB- gene .
25827424	0	xCT	14,17	NRF2	64,68	xCT	NRF2	23657	4780	Gene	Gene	Expression|nmod|START_ENTITY regulated|nsubjpass|Expression regulated|nmod|END_ENTITY	Expression of xCT and activity of system xc -LRB- - -RRB- are regulated by NRF2 in human breast_cancer cells in response to oxidative stress .
25002527	0	xCT	41,44	Nrf2	0,4	xCT	Nrf2	23657	4780	Gene	Gene	upregulation|nmod|START_ENTITY upregulation|amod|END_ENTITY	Nrf2 - and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder_carcinoma cells to proteasome inhibition .
26044038	0	xCT	67,70	Nrf2	26,30	xCT	Nrf2	23657	4780	Gene	Gene	Upregulation|nmod|START_ENTITY Upregulation|amod|END_ENTITY	Correction for Ye et al. , Nrf2 - and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder_Carcinoma Cells to Proteasome Inhibition .
11306054	0	xCTBP	71,76	Xenopus_cytosolic_thyroid-hormone-binding_protein	20,69	xCTBP	Xenopus cytosolic thyroid-hormone-binding protein	398147(Tax:8355)	398147(Tax:8355)	Gene	Gene	Characterization|appos|START_ENTITY Characterization|nmod|END_ENTITY	Characterization of Xenopus_cytosolic_thyroid-hormone-binding_protein -LRB- xCTBP -RRB- with aldehyde dehydrogenase activity .
7476970	0	xFF1rA	125,131	xFF1rA	82,88	xFF1rA	xFF1rA	397700(Tax:8355)	397700(Tax:8355)	Gene	Gene	domains|nmod|START_ENTITY END_ENTITY|nmod|domains	A naturally occurring short variant of the FTZ-F1-related nuclear orphan receptor xFF1rA and interactions between domains of xFF1rA .
7476970	0	xFF1rA	82,88	xFF1rA	125,131	xFF1rA	xFF1rA	397700(Tax:8355)	397700(Tax:8355)	Gene	Gene	START_ENTITY|nmod|domains domains|nmod|END_ENTITY	A naturally occurring short variant of the FTZ-F1-related nuclear orphan receptor xFF1rA and interactions between domains of xFF1rA .
12729562	0	xGCNF	50,55	germ_cell_nuclear_factor	24,48	xGCNF	germ cell nuclear factor	399304(Tax:8355)	399304(Tax:8355)	Gene	Gene	function|appos|START_ENTITY function|nmod|END_ENTITY	The function of Xenopus germ_cell_nuclear_factor -LRB- xGCNF -RRB- in morphogenetic movements during neurulation .
18978816	0	xIAP	97,101	TRAIL	35,40	xIAP	TRAIL	331	8743	Gene	Gene	downregulation|nmod|START_ENTITY END_ENTITY|nmod|downregulation	Sensitization of melanoma cells to TRAIL by UVB-induced and NF-kappaB-mediated downregulation of xIAP .
17981148	0	xSH3BP5L	71,79	Xenopus_SH3_domain_binding_protein_5_like	28,69	xSH3BP5L	Xenopus SH3 domain binding protein 5 like	495338(Tax:8355)	495338(Tax:8355)	Gene	Gene	gene|appos|START_ENTITY gene|amod|END_ENTITY	Characterization of a novel Xenopus_SH3_domain_binding_protein_5_like -LRB- xSH3BP5L -RRB- gene .
11091086	0	xSim	49,53	single-minded	128,141	xSim	single-minded	373634(Tax:8355)	41612(Tax:7227)	Gene	Gene	expression|nmod|START_ENTITY related|nsubj|expression related|nmod|END_ENTITY	Characterization and developmental expression of xSim , a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded .
10704858	0	xSix3	26,31	Six3	65,69	xSix3	Six3	373739(Tax:8355)	20473(Tax:10090)	Gene	Gene	START_ENTITY|appos|homologue homologue|nmod|END_ENTITY	Cloning and expression of xSix3 , the Xenopus homologue of murine Six3 .
7956361	0	xanthine_dehydrogenase	19,41	XDH	43,46	xanthine dehydrogenase	XDH	7498	7498	Gene	Gene	gene|nmod|START_ENTITY gene|appos|END_ENTITY	The human gene for xanthine_dehydrogenase -LRB- XDH -RRB- is localized on chromosome band 2q22 .
8661045	0	xanthine_dehydrogenase	52,74	XDH	81,84	xanthine dehydrogenase	XDH	7498	7498	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Molecular cloning and characterization of the human xanthine_dehydrogenase gene -LRB- XDH -RRB- .
18669934	0	xanthine_oxidoreductase	78,101	p38	40,43	xanthine oxidoreductase	p38	7498	1432	Gene	Gene	activation|nmod|START_ENTITY activation|amod|END_ENTITY	Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine_oxidoreductase in ventilator-induced lung_injury .
11562429	0	xenobiotic_receptor	111,130	CYP2H1	50,56	xenobiotic receptor	CYP2H1	395439(Tax:9031)	414746(Tax:9031)	Gene	Gene	mediate|nmod|START_ENTITY mediate|dobj|induction induction|nmod|END_ENTITY	Multiple_enhancer_units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic_receptor .
9753735	0	xeroderma_pigmentosum_group_A	37,66	XPA	68,71	xeroderma pigmentosum group A	XPA	7507	7507	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Mutational analysis of a function of xeroderma_pigmentosum_group_A -LRB- XPA -RRB- protein in strand-specific DNA repair .
23352696	0	xeroderma_pigmentosum_group_D	53,82	TFIIH	103,108	xeroderma pigmentosum group D	TFIIH	2068	2068	Gene	Gene	subunit|amod|START_ENTITY subunit|nmod|END_ENTITY	DNA quality control by a lesion sensor pocket of the xeroderma_pigmentosum_group_D helicase subunit of TFIIH .
10383938	1	xid	45,48	Btk	41,44	xid	Btk	12229(Tax:10090)	12229(Tax:10090)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	CBA/N _ mice carrying the defective Btk -LRB- xid -RRB- gene are resistant to pristane-induced plasmacytomagenesis .
3494095	0	xid	85,88	X-linked_immunodeficiency	58,83	xid	X-linked immunodeficiency	12229(Tax:10090)	12229(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|amod|END_ENTITY	Development of B lymphocytes in mice heterozygous for the X-linked_immunodeficiency -LRB- xid -RRB- mutation .
9394795	0	xid	61,64	X-linked_immunodeficiency	34,59	xid	X-linked immunodeficiency	12229(Tax:10090)	12229(Tax:10090)	Gene	Gene	mutation|appos|START_ENTITY mutation|compound|END_ENTITY	A re-evaluation of the effects of X-linked_immunodeficiency -LRB- xid -RRB- mutation on B cell differentiation and function in the mouse .
19906855	0	xol-1	0,5	TRA-1	116,121	xol-1	TRA-1	181061(Tax:6239)	176548(Tax:6239)	Gene	Gene	target|nsubj|START_ENTITY target|nmod|END_ENTITY	xol-1 , the master sex-switch gene in C. _ elegans , is a transcriptional target of the terminal sex-determining factor TRA-1 .
16569644	0	xylosyltransferase_I	57,77	XT-I	137,141	xylosyltransferase I	XT-I	64131	64131	Gene	Gene	expression|nmod|START_ENTITY expression|nmod|END_ENTITY	Cloning and recombinant expression of active full-length xylosyltransferase_I -LRB- XT-I -RRB- and characterization of subcellular localization of XT-I and XT-II .
23223231	0	xylosyltransferase_I	14,34	interleukin_1b	54,68	xylosyltransferase I	interleukin 1b	64131	3553	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Regulation of xylosyltransferase_I gene expression by interleukin_1b in human primary chondrocyte cells : mechanism and impact on proteoglycan synthesis .
22014179	0	y-butyrobetaine_hydroxylase	36,63	organic_cation_transporter-2	74,102	y-butyrobetaine hydroxylase	organic cation transporter-2	64564(Tax:10116)	29503(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|amod|END_ENTITY	The effects of exercise training on y-butyrobetaine_hydroxylase and novel organic_cation_transporter-2 gene expression in the rat .
24482231	0	yes-associated_protein	141,163	AKT	90,93	yes-associated protein	AKT	10413	207	Gene	Gene	role|nmod|START_ENTITY exert|dobj|role signaling|xcomp|exert signaling|nsubj|END_ENTITY	Cluster of differentiation 166 -LRB- CD166 -RRB- regulated by phosphatidylinositide_3-Kinase -LRB- PI3K -RRB- / AKT signaling to exert its anti-apoptotic role via yes-associated_protein -LRB- YAP -RRB- in liver_cancer .
26944315	0	yes-associated_protein	24,46	YAP	48,51	yes-associated protein	YAP	10413	10413	Gene	Gene	accumulation|nmod|START_ENTITY accumulation|appos|END_ENTITY	Nuclear accumulation of yes-associated_protein -LRB- YAP -RRB- maintains the survival of doxorubicin-induced senescent cells by promoting survivin expression .
12829732	0	yin_yang_1	78,88	FMO1	111,115	yin yang 1	FMO1	7528	2326	Gene	Gene	polymorphism|amod|START_ENTITY polymorphism|appos|END_ENTITY	Genetic variability at the human FMO1 locus : significance of a basal promoter yin_yang_1 element polymorphism -LRB- FMO1 * 6 -RRB- .
21097620	0	yuaB	14,18	Rok	0,3	yuaB	Rok	938831(Tax:224308)	938793(Tax:224308)	Gene	Gene	expression|amod|START_ENTITY regulates|dobj|expression regulates|nsubj|END_ENTITY	Rok regulates yuaB expression during architecturally complex colony development of Bacillus_subtilis 168 .
7846159	0	zeamatin-like_protein	49,70	Zlp	72,75	zeamatin-like protein	Zlp	542299(Tax:4577)	542299(Tax:4577)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Characterization and expression of an antifungal zeamatin-like_protein -LRB- Zlp -RRB- gene from Zea_mays .
8917316	0	zein	56,60	Opaque-2	80,88	zein	Opaque-2	732802(Tax:4577)	542375(Tax:4577)	Gene	Gene	expression|compound|START_ENTITY expression|nmod|END_ENTITY	The role of multiple binding sites in the activation of zein gene expression by Opaque-2 .
10982458	0	zein	107,111	opaque-2	127,135	zein	opaque-2	732802(Tax:4577)	542375(Tax:4577)	Gene	Gene	genes|compound|START_ENTITY genes|nmod|endosperms endosperms|amod|END_ENTITY	Specific combinations of zein genes and genetic backgrounds influence the transcription of the heavy-chain zein genes in maize opaque-2 endosperms .
10982458	0	zein	25,29	opaque-2	127,135	zein	opaque-2	732802(Tax:4577)	542375(Tax:4577)	Gene	Gene	genes|compound|START_ENTITY combinations|nmod|genes influence|nsubj|combinations influence|dobj|transcription transcription|nmod|genes genes|nmod|endosperms endosperms|amod|END_ENTITY	Specific combinations of zein genes and genetic backgrounds influence the transcription of the heavy-chain zein genes in maize opaque-2 endosperms .
1644294	0	zeste	0,5	Ultrabithorax	47,60	zeste	Ultrabithorax	31230(Tax:7227)	42034(Tax:7227)	Gene	Gene	activates|nsubj|START_ENTITY activates|dobj|transcription transcription|compound|END_ENTITY	zeste , a nonessential gene , potently activates Ultrabithorax transcription in the Drosophila embryo .
10510363	0	zeta-associated_protein-70	31,57	ZAP-70	59,65	zeta-associated protein-70	ZAP-70	7535	7535	Gene	Gene	kinase|amod|START_ENTITY kinase|compound|END_ENTITY	LFA-1 to LFA-1 signals involve zeta-associated_protein-70 -LRB- ZAP-70 -RRB- tyrosine kinase : relevance for invasion and migration of a T cell hybridoma .
7753863	0	zeta-crystallin	51,66	Pax-6	0,5	zeta-crystallin	Pax-6	100135507(Tax:10141)	100727368	Gene	Gene	expression|nmod|START_ENTITY essential|nmod|expression essential|nsubj|END_ENTITY	Pax-6 is essential for lens-specific expression of zeta-crystallin .
12615066	0	zetin_1	20,27	rBSPRY	28,34	zetin 1	rBSPRY	64027(Tax:10116)	64027(Tax:10116)	Gene	Gene	Characterization|nmod|START_ENTITY END_ENTITY|dep|Characterization	Characterization of zetin_1 / rBSPRY , a novel binding partner of 14-3-3 proteins .
11406282	0	zfBLP1	32,38	Bcl-XL	42,48	zfBLP1	Bcl-XL	114401(Tax:7955)	114401(Tax:7955)	Gene	Gene	START_ENTITY|appos|homologue homologue|amod|END_ENTITY	Cloning and characterization of zfBLP1 , a Bcl-XL homologue from the zebrafish , Danio_rerio .
23178405	0	zfh1	21,25	Imd	51,54	zfh1	Imd	43650(Tax:7227)	44339(Tax:7227)	Gene	Gene	downregulates|nsubj|START_ENTITY downregulates|dobj|END_ENTITY	Transcription factor zfh1 downregulates Drosophila Imd pathway .
19760181	0	zfh2	76,80	zinc_finger_homeodomain_2	49,74	zfh2	zinc finger homeodomain 2	657717(Tax:7070)	657717(Tax:7070)	Gene	Gene	gene|appos|START_ENTITY gene|compound|END_ENTITY	Insertional mutagenesis screening identifies the zinc_finger_homeodomain_2 -LRB- zfh2 -RRB- gene as a novel factor required for embryonic leg development in Tribolium_castaneum .
20232320	0	zfp42	36,41	Rex1	30,34	zfp42	Rex1	132625	132625	Gene	Gene	regulation|appos|START_ENTITY regulation|nmod|END_ENTITY	Transcriptional regulation of Rex1 -LRB- zfp42 -RRB- in normal prostate epithelial cells and prostate_cancer cells .
7566486	0	zif/268	15,22	basic_fibroblast_growth_factor	42,72	zif/268	basic fibroblast growth factor	24330(Tax:10116)	54250(Tax:10116)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	Stimulation of zif/268 gene expression by basic_fibroblast_growth_factor in primary rat striatal cultures .
12470865	0	zif268	13,19	EGR-1	6,11	zif268	EGR-1	1958	1958	Gene	Gene	expression|appos|START_ENTITY expression|compound|END_ENTITY	Basal EGR-1 -LRB- zif268 , NGFI-A , Krox-24 -RRB- expression in developing striatal patches : role of dopamine and glutamate .
15805312	0	zif268	62,68	Egr-1	55,60	zif268	Egr-1	1958	1958	Gene	Gene	Expression|appos|START_ENTITY Expression|nmod|END_ENTITY	Expression of the immediate-early gene-encoded protein Egr-1 -LRB- zif268 -RRB- during in vitro classical conditioning .
1613551	0	zif268	30,36	NGFI-A	22,28	zif268	NGFI-A	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	gene|dep|START_ENTITY gene|compound|END_ENTITY	Dynamic regulation of NGFI-A -LRB- zif268 , egr1 -RRB- gene expression in the striatum .
9191106	0	zif268	43,49	NGFI-A	51,57	zif268	NGFI-A	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	induction|amod|START_ENTITY induction|appos|END_ENTITY	Visual sensitivities of nur77 -LRB- NGFI-B -RRB- and zif268 -LRB- NGFI-A -RRB- induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses .
17372985	0	zif268	96,102	cdc20	23,28	zif268	cdc20	13653(Tax:10090)	107995(Tax:10090)	Gene	Gene	expression|nmod|START_ENTITY expression|nsubj|Regulation Regulation|nmod|END_ENTITY	Regulation of neuronal cdc20 -LRB- p55cdc -RRB- expression by the plasticity-related transcription factor zif268 .
15970222	0	zif268	21,27	egr-1	14,19	zif268	egr-1	24330(Tax:10116)	24330(Tax:10116)	Gene	Gene	mRNA|appos|START_ENTITY mRNA|amod|END_ENTITY	Expression of egr-1 -LRB- zif268 -RRB- mRNA in select fear-related brain regions following exposure to a predator .
12645566	0	zinc	63,67	ZPR9	49,53	ZPR9	ZPR9	90441	90441	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	Enhancement of B-MYB transcriptional activity by ZPR9 , a novel zinc finger protein .
15246563	0	zinc-alpha2-glycoprotein	10,34	ZAG	36,39	zinc-alpha2-glycoprotein	ZAG	12007(Tax:10090)	12007(Tax:10090)	Gene	Gene	Effect|nmod|START_ENTITY Effect|appos|END_ENTITY	Effect of zinc-alpha2-glycoprotein -LRB- ZAG -RRB- on expression of uncoupling proteins in skeletal muscle and adipose tissue .
20733350	0	zinc-finger_protein_143	28,51	IGF-1	0,5	zinc-finger protein 143	IGF-1	7702	3479	Gene	Gene	cells|amod|START_ENTITY expression|nmod|cells induces|dobj|expression induces|nsubj|END_ENTITY	IGF-1 induces expression of zinc-finger_protein_143 in colon_cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species .
12527199	0	zinc-fingers_and_homeoboxes_1	74,103	ZHX1	105,109	zinc-fingers and homeoboxes 1	ZHX1	22770(Tax:10090)	22770(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene .
14741719	0	zinc-fingers_and_homeoboxes_1	38,67	ZHX1	69,73	zinc-fingers and homeoboxes 1	ZHX1	22770(Tax:10090)	22770(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	A mechanism of induction of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene expression by interleukin-2 .
14741719	0	zinc-fingers_and_homeoboxes_1	38,67	interleukin-2	94,107	zinc-fingers and homeoboxes 1	interleukin-2	22770(Tax:10090)	16183(Tax:10090)	Gene	Gene	expression|amod|START_ENTITY expression|nmod|END_ENTITY	A mechanism of induction of the mouse zinc-fingers_and_homeoboxes_1 -LRB- ZHX1 -RRB- gene expression by interleukin-2 .
24907849	0	zinc_finger_407	13,28	ZNF407	30,36	zinc finger 407	ZNF407	55628	55628	Gene	Gene	-RSB-|amod|START_ENTITY -RSB-|compound|END_ENTITY	Mutations in zinc_finger_407 -LSB- ZNF407 -RSB- cause a unique autosomal_recessive_cognitive_impairment_syndrome .
20682777	0	zinc_finger_E-box-binding_homeobox_2	83,119	ZEB2	121,125	zinc finger E-box-binding homeobox 2	ZEB2	9839	9839	Gene	Gene	transcript|amod|START_ENTITY transcript|appos|END_ENTITY	Growth_hormone -LRB- GH -RRB- - dependent expression of a natural antisense transcript induces zinc_finger_E-box-binding_homeobox_2 -LRB- ZEB2 -RRB- in the glomerular podocyte : a novel action of gh with implications for the pathogenesis of diabetic_nephropathy .
25052237	0	zinc_finger_E-box-binding_homeobox_2	73,109	ZEB2	111,115	zinc finger E-box-binding homeobox 2	ZEB2	9839	9839	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	miR-200c modulates ovarian_cancer cell metastasis potential by targeting zinc_finger_E-box-binding_homeobox_2 -LRB- ZEB2 -RRB- expression .
15908750	0	zinc_finger_homeo_box_1B	79,103	ZFHX1B	110,116	zinc finger homeo box 1B	ZFHX1B	9839	9839	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Genitourinary_anomalies in Mowat-Wilson_syndrome with deletion/mutation in the zinc_finger_homeo_box_1B gene -LRB- ZFHX1B -RRB- .
26112950	0	zinc_finger_homeobox_3	26,48	ZFHX3	50,55	zinc finger homeobox 3	ZFHX3	463	463	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Rs7193343 polymorphism in zinc_finger_homeobox_3 -LRB- ZFHX3 -RRB- gene and atrial_fibrillation : an updated meta-analysis of 10 case-control comparisons .
19760181	0	zinc_finger_homeodomain_2	49,74	zfh2	76,80	zinc finger homeodomain 2	zfh2	657717(Tax:7070)	657717(Tax:7070)	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Insertional mutagenesis screening identifies the zinc_finger_homeodomain_2 -LRB- zfh2 -RRB- gene as a novel factor required for embryonic leg development in Tribolium_castaneum .
9132053	0	zinc_finger_protein	94,113	C2H2	89,93	zinc finger protein	C2H2	821212(Tax:3702)	830313(Tax:3702)	Gene	Gene	genes|compound|START_ENTITY genes|compound|END_ENTITY	Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc_finger_protein genes and cDNAs .
14706637	0	zinc_finger_protein_161	6,29	dopamine_transporter	72,92	zinc finger protein 161	dopamine transporter	7716	6531	Gene	Gene	START_ENTITY|appos|activator activator|nmod|END_ENTITY	Human zinc_finger_protein_161 , a novel transcriptional activator of the dopamine_transporter .
11279031	0	zinc_finger_protein_202	4,27	ATP_binding_cassette_transporter_A1	71,106	zinc finger protein 202	ATP binding cassette transporter A1	7753	19	Gene	Gene	repressor|nsubj|START_ENTITY repressor|nmod|END_ENTITY	The zinc_finger_protein_202 -LRB- ZNF202 -RRB- is a transcriptional repressor of ATP_binding_cassette_transporter_A1 -LRB- ABCA1 -RRB- and ABCG1 gene expression and a modulator of cellular lipid efflux .
22425527	0	zinc_finger_protein_804A	33,57	ZNF804A	24,31	zinc finger protein 804A	ZNF804A	91752	91752	Gene	Gene	analysis|appos|START_ENTITY analysis|nmod|END_ENTITY	Association analysis of ZNF804A -LRB- zinc_finger_protein_804A -RRB- rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia .
14981711	0	zinc_finger_protein_of_cerebellum_1	72,107	ZIC1	109,113	zinc finger protein of cerebellum 1	ZIC1	22771(Tax:10090)	22771(Tax:10090)	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Joubert_syndrome : a haplotype segregation strategy and exclusion of the zinc_finger_protein_of_cerebellum_1 -LRB- ZIC1 -RRB- gene .
17668883	0	zinc_fingers_and_homeoboxes_2	69,98	glypican_3	19,29	zinc fingers and homeoboxes 2	glypican 3	387609(Tax:10090)	14734(Tax:10090)	Gene	Gene	regulated|nmod|START_ENTITY regulated|nsubjpass|END_ENTITY	The oncofetal gene glypican_3 is regulated in the postnatal liver by zinc_fingers_and_homeoboxes_2 and in the regenerating liver by alpha-fetoprotein_regulator_2 .
21080911	0	zinc_ribbon_domain-containing_1	15,46	ZNRD1	8,13	zinc ribbon domain-containing 1	ZNRD1	30834	30834	Gene	Gene	Role|dep|START_ENTITY Role|nmod|END_ENTITY	Role of ZNRD1 -LRB- zinc_ribbon_domain-containing_1 -RRB- in angiogenesis of leukaemia cells .
24306209	0	zinc_transporter-8	21,39	SLC30A8	46,53	zinc transporter-8	SLC30A8	55532	169026	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Interactions between zinc_transporter-8 gene -LRB- SLC30A8 -RRB- and plasma zinc concentrations for impaired_glucose_regulation and type_2_diabetes .
15247287	0	zizimin1	52,60	Cdc42	10,15	zizimin1	Cdc42	23348	998	Gene	Gene	factor|appos|START_ENTITY factor|amod|END_ENTITY	The novel Cdc42 guanine_nucleotide exchange factor , zizimin1 , dimerizes via the Cdc42-binding CZH2 domain .
9739427	0	zona_pellucida_2	32,48	ZP2	50,53	zona pellucida 2	ZP2	7783	7783	Gene	Gene	protein|amod|START_ENTITY protein|appos|END_ENTITY	Immunological identification of zona_pellucida_2 -LRB- ZP2 -RRB- protein in human oocytes .
21911476	0	zona_pellucida_binding_protein_1	32,64	ZPBP1	66,71	zona pellucida binding protein 1	ZPBP1	11055	11055	Gene	Gene	gene|amod|START_ENTITY gene|appos|END_ENTITY	Association of mutations in the zona_pellucida_binding_protein_1 -LRB- ZPBP1 -RRB- gene with abnormal sperm head morphology in infertile men .
8984189	0	zona_pellucida_protein_1	27,51	ZP1	53,56	zona pellucida protein 1	ZP1	106509336	106509336	Gene	Gene	Binding|nmod|START_ENTITY Binding|appos|END_ENTITY	Binding of recombinant pig zona_pellucida_protein_1 -LRB- ZP1 -RRB- to acrosome-reacted spermatozoa .
9126492	0	zonadhesin	67,77	ZAN	84,87	zonadhesin	ZAN	22635(Tax:10090)	7455	Gene	Gene	gene|compound|START_ENTITY gene|appos|END_ENTITY	Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene -LRB- ZAN -RRB- .
15183511	0	zonula_occludens-1	98,116	Cx47	76,80	zonula occludens-1	Cx47	21872(Tax:10090)	118454(Tax:10090)	Gene	Gene	association|nmod|START_ENTITY association|amod|END_ENTITY	Connexin47 , connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula_occludens-1 -LRB- ZO-1 -RRB- in mouse brain .
24413171	0	zonula_occludens-1	24,42	Vinculin	0,8	zonula occludens-1	Vinculin	21872(Tax:10090)	22330(Tax:10090)	Gene	Gene	binds|xcomp|START_ENTITY binds|nsubj|END_ENTITY	Vinculin directly binds zonula_occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes .
25683991	0	zonula_occludens-1	63,81	interleukin-13	11,25	zonula occludens-1	interleukin-13	7082	3596	Gene	Gene	expression|nmod|START_ENTITY Effects|nmod|expression Effects|nmod|END_ENTITY	Effects of interleukin-13 and montelukast on the expression of zonula_occludens-1 in human podocytes .
20150971	0	zonula_occludens-1	84,102	phosphatidylinositol_3-kinase	108,137	zonula occludens-1	phosphatidylinositol 3-kinase	7082	5293	Gene	Gene	START_ENTITY|nmod|signaling signaling|amod|END_ENTITY	Hypercholesterolaemic serum increases the permeability of endothelial cells through zonula_occludens-1 with phosphatidylinositol_3-kinase signaling pathway .
17579252	0	zonula_occludens-1_protein	45,71	Connexin_36	0,11	zonula occludens-1 protein	Connexin 36	292994(Tax:10116)	50564(Tax:10116)	Gene	Gene	expressed|nmod|START_ENTITY expressed|nsubjpass|END_ENTITY	Connexin_36 is expressed and associated with zonula_occludens-1_protein in PC-12 cells .
19267955	0	zonula_occludens_protein-1	76,102	ZO-1	104,108	zonula occludens protein-1	ZO-1	396567(Tax:9823)	396567(Tax:9823)	Gene	Gene	expression|amod|START_ENTITY expression|appos|END_ENTITY	Supplemental zinc reduced intestinal permeability by enhancing occludin and zonula_occludens_protein-1 -LRB- ZO-1 -RRB- expression in weaning piglets .
24583807	0	zygote-specific_proteasome_assembly_chaperone	23,68	ZPAC	17,21	zygote-specific proteasome assembly chaperone	ZPAC	105418(Tax:10090)	105418(Tax:10090)	Gene	Gene	role|appos|START_ENTITY role|nmod|END_ENTITY	Possible role of ZPAC , zygote-specific_proteasome_assembly_chaperone , during spermatogenesis in the mouse .
17572661	0	zyxin	23,28	Akt	0,3	zyxin	Akt	7791	207	Gene	Gene	phosphorylation|nmod|START_ENTITY phosphorylation|compound|END_ENTITY	Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation .
19853601	0	zyxin	46,51	Synemin	0,7	zyxin	Synemin	7791	23336	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration .
18695732	0	zyxin	72,77	Xanf1	24,29	zyxin	Xanf1	100049724(Tax:8355)	378542(Tax:8355)	Gene	Gene	interacts|nmod|START_ENTITY interacts|nsubj|END_ENTITY	-LSB- Transcriptional factor Xanf1 interacts with the focal adhesion protein zyxin in the early development of the Xenopus_laevis brain -RSB- .
23427270	0	zyxin	18,23	ZYX-1	0,5	zyxin	ZYX-1	174951(Tax:6239)	174951(Tax:6239)	Gene	Gene	protein|compound|START_ENTITY END_ENTITY|appos|protein	ZYX-1 , the unique zyxin protein of Caenorhabditis_elegans , is involved in dystrophin-dependent muscle_degeneration .
18413140	0	zyxin	33,38	alpha-Actinin	0,13	zyxin	alpha-Actinin	7791	87	Gene	Gene	links|dep|START_ENTITY links|nsubj|END_ENTITY	alpha-Actinin links LPP , but not zyxin , to cadherin-based junctions .
10224105	0	zyxin	33,38	alpha-actinin	3,16	zyxin	alpha-actinin	7791	87	Gene	Gene	site|nmod|START_ENTITY site|amod|END_ENTITY	An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment .
10224105	0	zyxin	68,73	alpha-actinin	3,16	zyxin	alpha-actinin	418300(Tax:9031)	87	Gene	Gene	localization|compound|START_ENTITY essential|nmod|localization essential|nsubj|site site|amod|END_ENTITY	An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment .